along thorough development underground engineering people pay attention long term deformation stability tunnels however creep characteristic important factor arouse surrounding rock deformation failures control engineering designs phyllite common soft rock engineering practice sample saturated water impose softening effect phyllite also influence creep mechanical properties long term loads paper selecting samples headrace tunnel gaopingpu hydropower station china carried shear creep test saturated phyllite along schistosity surface different stress levels systematically analyzed compared test results samples air dried conditions found water great effects strength phyllite long term strength yield stress saturated phyllite air dried ones respectively time based burgers creep model discussed impacts water creep parameters values phyllite result provide theoretical basis calculate creep deformation tunnel surrounding rocks
operant extinction learning supress previously rewarded behavior known strongly associated specific context acquired limits therapeutic use operant extinction behavioral treatments addiction examined whether sleep influences contextual memory operant extinction time using two different recall tests recent remote rats trained operant conditioning task lever press context underwent extinction training context followed retention period contained either spontaneous morning sleep morning sleep deprivation spontaneous evening wakefulness recall test performed either immediately experimental retention period recent recall remote extinction context novel context two main findings recent recall test sleep comparison sleep deprivation spontaneous wakefulness enhanced extinction memory extinction context remote recall extinction performance sleep enhanced contexts extent comparable levels recent recall context interestingly extinction performance remote recall also improved sleep deprivation groups contexts difference performance sleep group results suggest post learning sleep transiently facilitate context specificity operant extinction recent recall however improvement contextual generalization operant extinction memory observed long term require immediate post learning sleep
paper presents cloud based system framework based bigtable mapreduce data storage processing paradigms providing web based service viewing storing analyzing massive building information models bims cloud web technologies utilized develop bim data center handle big data massive blms using multiple servers distributed manner accessed multiple users concurrently submit view bims online traditional bim include static information geometric parameters physical properties spatial relations modeling physical space study bim extended dynamic bim includes dynamic data historical records monitoring facility environment usage owing extension dynamic bim became parametric model used simulate user behaviors client side study applied webgl web interface development achieve display bims browsers users access services via various online devices anytime anywhere view model online server side study used apache hadoop utilize multiple servers provide mass storage spaces distributed manner bigtable like structured storage establish bim data center schema storing big data massive dynamic bims bigtables proposed mapreduce hadoop component parallel processing large data sets utilized process big data dynamic bims big data analysis framework effectively retrieve calculate required information dynamic bims data center various applications mapreduce distributed computing proposed study provide principle architecture proposed framework along experimental assessment results confirmed scalable reliable management massive bims achieved using proposed framework elsevier rights reserved
background pain one commonly reported symptoms people living hiv aids whether receiving anti retroviral therapy recent systematic review identified paucity studies exploring pain women low middle income countries prevalence characteristics pain women living hiv aids may differ men many chronic pain conditions prevalent women aims study establish pain prevalence characteristics management amaxhosa women living hiv aids addition aimed identify whether associations pain population psychosocial factors employment education self efficacy depression post traumatic stress disorder health related quality life childhood trauma methods cross sectional study women undergone hiv testing registered patients community health centre conducted data collected interview demographic questionnaire brief pain inventory xhosa childhood trauma questionnaire xhosa harvard trauma questionnaire xhosa ptsd self efficacy managing chronic disease item scale xhosa health related quality life instrument beck depression inventory results women pain prevalence rate women reported significant pain pain severity pain interference two women receiving adequate pain management according pain management index participants reported mean different anatomical sites pain unemployed participants group pain significantly fewer years schooling pain lower self efficacy health related quality life increased depression ptsd symptom severity conclusion study highlights pain common problem amaxhosa women living hiv aids data emphasise need prioritise pain assessment management amaxhosa women living hiv aids routinely assessing presence pain women hiv aids potential improve pain management minimise impact pain function
zoanthamine type alkaloids display wide spectrum biological effects study aimed examine inhibitory effects norzoanthamine ten homologues zoanthamine class human fibroblast collagenase modeling three dimensional structure ligands collagenase using energy minimization docking molecular dynamics simulation gbsa binding free energy calculations results showed zoanthamide zooxathellamine enol iminium form norzoanthamine lower binding free energies compounds potent inhibitors collagenase however enol iminium form norzoanthamine showed inhibitory activity collagenase keto form suggests used treatment many diseases osteoporosis autoimmune diseases cancer zinc binding residues hydrogen bonds leu tyr val leu pro ser hydrophobic interactions considered designing inhibitor collagenase theoretical results gbsa binding free energy calculations consistent experimental studies
autism spectrum disorder asd neurodevelopmental disorder commonly seen children characterized age inappropriate impaired social communication presence stereotypic behavior disorder hypothesized result cerebral dysfunction arising complex interaction genetic epigenetic environmental factors asd suspected children failing asd specific screening tests presence red flags social language play domains children developmental language delay abnormal behavior poor school performance high risk comprehensive assessment comprises step wise approach includes taking detailed history performing holistic examination observing child closely relation play social interaction behavior diagnosis established application diagnostic criteria asd diagnostic statistical manual mental disorders edition dsm degree severity intellectual language impairment presence illnesses specified functional assessment identifies individual strengths weaknesses important formulate customized intervention plan along family goal build skills enabling optimal far possible normal functioning simultaneously reducing maladaptive behavior achieved multi disciplinary team comprising various personnel experienced tackling issues asd related respective areas expertise intervention primarily non pharmacological based behavioral modification strategies drugs indicated reduction target symptoms refractory behavioral intervention although cure timely appropriate intervention improve quality life significantly
since introduction late eighties early nineties last century flat systems become well established control theory also control engineering stems fact class systems trajectories planned easily moreover lumped parameter systems trajectories stabilized straightforward way contribution short introduction basics control design trajectory planning stabilization shown demonstrated two simple examples namely gyroscopic pendulum well uniaxial model car extensive illustrative example finally trajectory planning nonlinear control gantry crane discussed theoretic results simulations laboratory experiments presented
like things fracking good bad points former regard technological breakthrough increase supplies energy entire economy latter linked increased incidence earthquakes water pollution surely negatives well evidence fracking would exist least present extent government subsidies argue misallocate resources
computer networks emerging everyday life network security become important issue simultaneously attacks becoming sophisticated making defense computer networks increasingly difficult attack graph modelling tool used assessment security enterprise networks since introduction considerable amount research effort spent development theory practices around idea attack graph paper presents consolidated view major attack graph generation analysis techniques
affinity tags vital tools production high throughput recombinant proteins several affinity tags hexahistidine tag maltose binding protein streptavidin binding peptide tag calmodulin binding peptide myc tag glutathione transferase flag tag introduced recombinant protein production fragment crystallizable domain igg antibody one useful affinity tags facilitate detection purification localization proteins improve immunogenicity modulatory effects physicochemical pharmaceutical properties proteins recombinant forms group recombinant proteins called fusion proteins ffps ffps widely used drug discovery drug delivery vaccine design experimental research receptor ligand interactions fusion proteins become successful alternatives monoclonal antibodies drug developments review physicochemical biochemical immunological pharmaceutical therapeutic properties recombinant ffps discussed new generation bioengineering strategies
sport injuries common costly professional athlete weekend warrior community acute injuries treated according current guidelines aim bringing athlete back arena guidelines taken account new scientific results inflammatory process following trauma hallmarks inflammation namely pain swelling redness heat results adequate inflammatory response aim bringing affected tissue back restitution latin restitutio integrum cooling affected limb anti inflammatory drugs widely used may deter healing healing process governed fatty acids omega omega series order facilitate healing fatty acids present significant amounts affected tissues trauma occurs particularly relevant marine omega fatty acids often running low due insignificant intake seafood common individuals practicing sports high energy sports often lead head brain trauma continuous head traumata may even result later mental defects saturation brain cells omega fatty acids particular docosahexaenoic acid dha may facilitate healing brain trauma thereby counteracting negative long term results present understanding normal inflammatory process leading restitution discussed along data recent scientific trials
development efficient adsorbents high sorption capacity remains challenge removal micropollutants occurred globally water resources work poly amic acid paa electrospun nanofiber membranes grafted hyperbranched polyols synthesized used boron removal paa nanofiber reacted hyperbranched polyethylenimine hpei glycidol introduce vicinal hydroxyl groups chemical composition surface characteristics obtained paa membranes evaluated fesem ftir xps water contact angles wca measurements boron adsorption thermodynamics kinetics investigated systematically results showed paa nanofiber spun concentration uniform morphology narrow diameter distribution paa nanofiber membrane maximum boron uptake mmol could adsorb mmol boron solution min high surface area nanofibers hyperbranched structure contribute high boron uptake high adsorption rate nanofiber membrane obeyed langmuir adsorption model pseudo first order kinetic model regeneration efficiency nanofiber membrane remained cycled uses indicating good regenerability membrane elsevier rights reserved
geodynamics simulations characterized theological nonlinearity localization three dimensional effects separate interacting length scales features represent challenge computational science discuss leading software framework advanced scientific computing portable extensible toolkit scientific computation petsc facilitate development geodynamics simulations illustrate use petsc describe simulations steady state non newtonian passive flow thermal structure beneath mid ocean ridge magmatic solitary waves mantle iii formation localized bands high porosity two phase medium deformed simple shear highlight two supplementary features petsc structured storage application parameters self documenting output especially useful geodynamics simulations elsevier rights reserved
work presents new method examining structure public transport networks ptns analyzes topological properties combination computer programming statistical data large network analyses order automate extraction processing exporting data software program developed allowing extract needed data general transit feed specification thus overcoming difficulties occurring accessing collecting data proposed method applied real life ptnin auckland new zealand purpose examining whether showed characteristics scale free networks exhibited features small world networks result new regression equations derived analytically describing observed strong non linear relationships among probabilities randomly chosen stops ptn serviced given number routes established dependence best fitted exponential rather power law function showing ptn examined neither random scale free mixture two finding explains presence hubs typical exponential networks simultaneously highly connected nodes case scale free networks hand observed values topological properties network show although highly clustered owing representation directed graph differs slightly small world networks characterized strong clustering short average path length elsevier rights reserved
objectives assess knowledge provision emergency contraception particularly effective methods study design web based survey distributed cross sectional convenience sample healthcare providers across specialties treating reproductive aged women survey sent practicing physicians advanced practice clinicians academic centers february april analyzed responses provider specialty using multivariable logistic regression results fmal sample included providers response rate ninety five percent respondents heard levonorgestrel lng among reproductive health specialists provide lng practice although half heard ulipristal acetate upa provide majority family medicine emergency medicine provide lng contrast internists pediatricians however effective methods upa copper intrauterine device iud little known rarely provided outside reproductive health specialties internists emergency medicine providers heard upa provide emergency providers pediatricians heard copper iud used among reproductive health specialists provide copper iud practice specialty provider type proportion women reproductive age practice related knowledge provision forms conclusions awareness provision effective methods upa copper iud provider dependent substantially lower lng especially among providers focus reproductive health implications sample healthcare providers diverse specialties treat reproductive aged women knowledge provision effective forms upa copper iud far lower lng women offered full range methods elsevier inc rights reserved
past years software architecture become important sub field software engineering substantial advancement developing new technical approaches start handling architectural design engineering discipline measurement essential part engineering discipline quantifying quality attributes software architecture reveal good insights architecture also help architects practioners choose best fit alternative architectures meets needs work paves way researchers start investigating ways measure software architecture quality attributes measurement qualities essential sub field software engineering work explores stability understandability software architecture several metrics affect literature review qualities
variable ratio gearbox vrg used drivetrain small medium size wind turbine improve aerodynamic efficiency currently commercially available wind turbines operate using fixed gear ratio turbine rotor electrical generator vrg allows wind turbines constant speed generator discretely vary rotor speed achieve greater aerodynamic efficiency authors previous results demonstrate viability vrg design research quantifies gain efficiency vrg enabled wind turbine based wind data representing seven wind classifications method also presented identify turbine sites provide vrg greatest opportunities increase production overall findings suggest vrg benefit wind turbines irrespective wind class wind profiles study experiencing gains greater elsevier ltd rights reserved
background chronic rhinosinusitis nasal polyps associated local immunoglobulin hyperproduction presence ige antibodies staphylococcus aureus enterotoxins saes aspirin exacerbated respiratory disease severe form chronic rhinosinusitis nasal polyps nearly patients express anti saes objectives aimed understand antibodies reactive saes determine whether recognize saes complementarity determining regions cdrs framework regions methods labeled staphylococcal enterotoxin sed see used isolate single sae specific cells nasal polyps patients aspirin exacerbated respiratory disease using fluorescence activated cell sorting recombinant antibodies matched heavy light chains cloned igg high affinity specific saes assayed means elisa surface plasmon resonance recloned ige antigen binding fragments ige activities tested basophil degranulation assays results thirty seven sae specific igg iga expressing cells isolated yielded anti sae clones sea sed see competition binding assays revealed anti see antibodies recognize nonoverlapping epitopes see unexpectedly anti see mediated see induced basophil degranulation igg antigen binding fragments anti see enhanced degranulation anti see conclusions sees activate basophils simultaneously binding antigens conventional manner cdrs superantigens framework regions anti see ige anti see ige epsilon complexes anti see igg enhance activity anti see iges conventional antibodies cdrs simultaneously conventional antibodies superantibodies cdrs framework regions sees see anti see ige epsilon complexes
rapid development internet technology new methodologies techniques based data analysis increasing popular decision making many aspects society economy including insurance system research focus current challenges faced senior insurance system china acceleration population aging rising prevalence rate chronic diseases among aging population increasing burden senior insurance system paper based analysis clhls data beijing university data sources mainly investigated relationship social insurance health level senior population multiple linear regression model grossman health function preliminary conclusions drawn study follows comparison regression coefficients clear three kinds basic medical care different effects health level senior population interpretation function medical insurance senior health level lower social decisions social support factors influence pension insurance minor furthermore paper studied coupling mechanism among pension medical nursing insurances put forward suggestions merging pension medical nursing insurances one single plan improve efficiency performance current social security service system
objective aim study investigate effect radiographic spinal progression disease activity function spinal mobility patients ankylosing spondylitis treated tumor necrosis factor alpha tnf alpha inhibitors years methods patients participated longterm open label extensions clinical trials tnf alpha inhibitors receiving infliximab receiving etanercept included analysis based availability spinal radiographs performed baseline later timepoint followup spinal radiographs scored according modified stoke ankylosing spondylitis spine score msasss function assessed bath ankylosing spondylitis functional index basfi spinal mobility bath ankylosing spondylitis metrology index basmi disease activity bath ankylosing spondylitis disease activity index basdai results initial improvement basfi basmi remained remarkably stable low levels years despite radiographic spinal progression generalized mixed effects model analysis association msasss basfi change beta found effect msasss changes basmi changes time beta basdai showed strong association function beta lesser extent spinal mobility beta conclusion functional status spinal mobility patients established remained stable longterm anti tnf alpha therapy despite radiographic progression indicates reduction continuous control inflammation might able outweigh functional effect structural damage progression
recent graphic processing units gpus remarkable raw computing power used computationally challenging problems like micromagnetic simulations magnetostatic field computation analyze magnetic behavior small time space scale demands huge computation time paper presents multidimensional fft based parallel implementation magnetostatic field computation gpus developed specialized fft library magnetostatic field calculation gpus made possible fully exploit symmetries inherent field calculation optimizations specific gpus architecture compared results widely used cpu based parallel oommf program equivalent serial implementation cpu results shown speedup single double precision floating point accuracy equivalent serial implementation oommf respectively
introduction development quantitative methods detection viral nucleic acids significantly improved ability manage disease progression assess efficacy antiviral treatment moreover major advances molecular technologies last decade allowed identification new host genetic markers associated antiviral drug response also strongly revolutionized way see perform virus diagnostics coming years areas covered review describe history development virology diagnostic methods dedicating particular emphasis gradual evolution recent advances toward introduction multiparametric platforms syndromic diagnosis parallel outline consolidation viral genome quantification practice different clinical settings expert commentary rapid accurate affordable molecular technology predictable particular emphasis emerging techniques next generation sequencing digital pcr point care testing syndromic diagnosis simplify viral diagnosis next future
paper present current mode electronically tunable multifunction frequency filter behavior equivalent well known khn filter proposed structure one low impedance input zero potential three high impedance outputs low band high pass responses mutually independent control quality factor natural frequency omega made electronically tunable current conveyors eccii behavior structure verified spice simulations furthermore experimental measurements transient analyses performed
adolescent stress related growth refers enhancement adolescent cognitive affective social resources result experiencing stressors tested whether adolescents reporting high levels stress related growth showed superior adaptation outcomes day day basis participants females age completed questionnaire measure stress related growth kept diary emotional interpersonal functioning consecutive days individual differences cognitive affective stress related growth moderated associations daily stress levels adaptive coping behaviors whereas individual differences social stress related growth moderated associations daily mother child conflict end day negative affect study provides first empirical demonstration domain specific forms stress related growth adolescence
background government strategy indicates individuals learning disabilities access adapted psychological therapies dialectical behaviour therapy dbt recommended treatment borderline personality disorder bpd however little published research regarding whether appropriately adapted adults learning disabilities research available primarily focuses measures behavioural psychiatric change little emphasis psychological changes occur materials methods two case studies presented using repertory grid technique based personal construct psychology pcp individuals completed repertory grids prior following adapted dbt adults learning disabilities within specialist community psychology service united kingdom results case studies show psychological changes occurred within adults learning disabilities received adapted dbt within community psychology service changes included altered self esteem dilemmas individuals conclusion contrasting case studies demonstrate complexity idiosyncrasy experiences individuals learning disabilities receive dbt discuss information integrated clinical practice
despite number studies highlighting important impact chief executive officers ceos firms several theoretical methodological questions cloud existing findings study takes alternative approach examining shareholders perceptions ceo significance changed time using event study methodology sample sudden unexpected ceo deaths show absolute unsigned market reactions events public firms increased markedly results indicate shareholders act ways consistent belief ceos become increasingly influential recent decades managerial summary chief executive officers ceos facing increased scrutiny receiving ever increasing pay packages substantial debate exists overall contribution firm outcomes prior research sought calculate proportion firm outcomes attributable ceo study takes alternative approach using wisdom crowds assess shareholders think importance ceos study finds shareholders perhaps financially motivated stakeholder view ceos increasingly important drivers firm outcomes good bad versus peers decades earlier notably market reaction unexpected death ceo increased steadily last six decades highlighting importance succession planning supporting least partially increased compensation given today top executives copyright john wiley sons ltd
researchers software engineering attempted improve software development mining analyzing software repositories since majority software engineering data unstructured researchers applied information retrieval techniques help software development recent advances especially statistical topic models helped make sense unstructured data software repositories even however even though hundreds studies applying topic models software repositories study shows models used software engineering research community software engineering tasks supported topic models moreover since performance topic models directly related model parameters usage knowing researchers use topic models may also help future studies make optimal use models thus surveyed articles software engineering literature make use topic models find studies centre around limited number software engineering tasks studies use basic topic models iii researchers usually treat topic models black boxes without fully exploring underlying assumptions parameter values paper provides starting point new researchers interested using topic models may help new researchers practitioners determine best apply topic models particular software engineering task
lung transplant recipients ltr high risk cutaneous squamous cell carcinoma scc voriconazole exposure lung transplant recently reported risk factor scc sought study relationship fungal prophylaxis voriconazole risk scc sequential cohorts single center evaluated adult ltr ucla center instituted protocol switch targeted universal antifungal prophylaxis least months post transplant using cox proportional hazards models time scc compared targeted universal prophylaxis cohorts cox models also used assess scc risk function time dependent cumulative exposure voriconazole antifungal agents risk scc greater universal prophylaxis cohort voriconazole exposure greater universal prophylaxis cohort cumulative exposure voriconazole associated scc even adjustment important scc risk factors voriconazole increase risk advanced tumors exposure antifungal agents associated scc voriconazole used cautiously population
hypoxia essential development autoimmune diseases rheumatoid arthritis associated expression reactive oxygen species ros enhanced infiltration immune cells aim study demonstrate feasibility measuring hypoxia noninvasively vivo arthritic ankles pet mri using hypoxia tracers fluoromisonidazole fmiso fluoroazomycinarabinoside faza additionally quantified temporal dynamics hypoxia ros stress using ros sensitive chemiluminescence optical imaging probe analyzed expression hypoxia inducible factors hifs methods mice underwent noninvasive vivo pet mri measure hypoxia optical imaging analyze ros expression additionally performed vivo pimonidazole hif alpha immunohistochemistry hif alpha alpha western blot messenger rna analysis inflamed healthy ankles confirm vivo results results mice diseased experimental exhibited fold enhancement hypoxia tracer uptake even early disease stages fold elevation ros expression inflamed ankles compared ankles healthy controls found strong correlations noninvasive vivo hypoxia pet data pimonidazole expression hif alpha arthritic ankles strongest hypoxia tracer uptake observed soon day whereas pronounced ros stress evident day onset experimental indicating tissue hypoxia precede ros stress conclusion collectively first time knowledge demonstrated noninvasive measurement hypoxia inflammation using faza fmiso pet imaging represents promising new tool uncovering monitoring rheumatic inflammation vivo hypoxic inflamed tissues associated overexpression hifs specific inhibition hifs might represent new powerful treatment strategy
foetal breathing mice results prenatal activity two coupled hindbrain oscillators considered responsible respiratory rhythm generation birth pre botzinger complex prebotc active shortly onset foetal breathing parafacial respiratory group embryo starts activity one day earlier transcription factors identified essential specify neural progenitors lineages forming oscillators early development neural tube hoxa egr krox phoxb lbx atoh dbx evx prebotc eventually grow contralateral axons requiring expression robo inactivation genes encoding factors leads mis specification neurons distinct breathing abnormalities apneic patterns loss central chemosensitivity central congenital hypoventilation syndrome cchs humans complete loss breathing prebotc right left desynchronized breathing robo mutants mutations affecting development rostral pontine respiratory territories change shape inspiratory drive without affecting rhythm primordial embryonic oscillators start mouse three days generate low frequency rhythms probably required activity dependent development neurones embryonic stages foetus however actively silenced avoid detrimental interaction going respiratory rhythm altogether observations provide strong support previously proposed hypothesis functional organization respiratory generator specified early stages development dual nature comprising two serially non homologous oscillators elsevier rights reserved
time cost quality three important often conflicting factors must optimally balanced planning management construction projects tradeoff optimization among three factors within project scope necessary maximize overall project success paper moa bcde tcqt new hybrid multiple objective evolutionary algorithm based hybridization artificial bee colony differential evolution proposed solve time cost quality tradeoff problems proposed algorithm integrates crossover operations differential evolution original artificial bee colony abc order balance exploration exploitation phases optimization process numerical construction project case study demonstrates ability moa bcde generated non dominated solutions assist project managers select appropriate plan optimize tcqt operation typically difficult time consuming comparisons moa bcde four currently used algorithms including non dominated sorting genetic algorithm nsga multiple objective particle swarm optimization mopso multiple objective differential evolution mode multiple objective artificial bee colony moabc verify efficiency effectiveness developed algorithm elsevier rights reserved
backgroundrecurrent abdominal pain common costly health care problem attributed part visceral hypersensitivity increasing evidence suggests gut bacteria contribute abdominal pain perception modulating microbiome gut brain axis however specific microbial signals remain poorly defined aminobutyric acid gaba principal inhibitory neurotransmitter key regulator abdominal central pain perception peripheral afferent neurons although gut bacteria reported produce gaba known whether microbial derived neurotransmitter modulates abdominal pain methodsto investigate potential analgesic effects microbial gaba performed daily oral administration specific bifidobacterium strain dentiumatcc rat fecal retention model visceral hypersensitivity subsequently evaluated pain responses key resultswe demonstrate commensal bifidobacterium dentium produces gaba via enzymatic decarboxylation glutamate gadb daily oral administration specific bifidobacterium gadb deficient strain modulated sensory neuron activity rat fecal retention model visceral hypersensitivity conclusions inferencesthe functional significance microbial derived gaba demonstrated gadb dependent desensitization colonic afferents murine model visceral hypersensitivity visceral pain modulation represents another potential health benefit attributed bifidobacteria gaba producing species intestinal microbiome targeting gabaergic signals along microbiome gut brain axis represents new approach treatment abdominal pain
hydrodynamic performance marine mussel mytilus galloprovincialis studied time resolved particle image velocimetry evaluated inhalant flow exhalant jet flow suction performance flow control capabilities mussels quantitatively inhalant flow structures mussels measured coronal plane first time literature nutrient fluid convected mussel three dimensional sink flow inhalant velocity reaches highest magnitude inside mussel mantle accelerating outward mussels calculated pressure gradient coronal plane inhalant flow approaches mussel shell tip suction force generated inhalant flow increases becomes significant shell tip likewise exhalant jet flow regimes studied mussels mussels control exhalant jet flow structure single potential core region double potential core region vice versa peak exhalant jet velocity generated mussels changes function mussel cavity volume measurements hydrodynamic dissipation sagittal plane revealed interaction inhalant exhalant jet flow indicating energy efficient synchronized pumping mechanism efficient pumping mechanismis associated flow turning angle inhalant exhalant jet flows similar degrees degrees
one main problems ambient intelligence systems developers design implement different user interfaces combination user environmental characteristics paper deals alleviating problem implementation development framework called dandelion postpones run time implementation specific scenario particular address autonomous evaluation adequateness interaction devices scenario order facilitate final automatic generation adapted
burgeoning volume torrential data continues grow exponentially age internet things torrent digital datasets continue outgrow datacenters focus needs shifted stored data reduction methods pertaining nosql databases traditional structured storage systems continuously tend face challenges providing required storage throughputs computational power requirements necessary capture store manage analyze deluge data deduplication systems thus designed retain single copy redundant data disk save disk space want keep certain copies intentionally need wishful elimination paper leverages hadoop framework design develop duplication detection system detects multiple copies data right file level transmission thereafter various datasets tuned better performance analysed using mapreduce hive pig
part larger study perceived stress headaches momentary perceived stress head pain levels stress related symptom data collected paper explores temporal analysis patterns stress well analysis momentary retrospective stress related symptoms compared level headache activity adolescent girls ages randomly cued electronic diaries times per day day period responding momentary questions level head pain perceived stress stress related symptoms multivariate general linear modelling used determine significant differences among headache groups relation temporal patterns stress significant headache group differences found retrospective momentary stress related symptom measures total diary responses captured stress levels head pain related symptoms chronic headache group reported highest levels hourly daily stress followed moderate headache low headache groups patterns stress three headache groups statistically distinct illustrating increased stress girls frequent head pain evidence suggests increased stress girls recurrent head pain likely vulnerable population may benefit stress reducing interventions copyright john wiley sons ltd
article presents functional schemes two ipmodules included new radiation hardened structured arrays mhxa microcircuits main modifications amps oas current negative feedback cnf realized base due interconnection wiring elements terminal parameters amps considered practical recommendations choosing steady state behaviors active passive elements providing peak values slew rate upper frequency limit amp wide range changes transfer ratios given properties new subclass amps based mhxa circuits called generalized current negative feedback combining properties classical amps voltage feedback amps cnf examined
introduction parkinson disease compelling data indicate functional link adenosine dopamine receptors progression neurodegenerative process present study carried evaluate effect non selective adenosine receptor adr antagonist caffeine well selective antagonists cyclopentyl dipropylxanthine dpcpx adrsa antagonist diethyl dimethoxystyryl methyl dihydro purine dione adrsa antagonist prevention methyl phenyl tetrahydropyridine mptp induced parkinsonism mice material methods mice allocated five groups group control group group mptp group received four injections mptp intervals groups iii received mptp caffeine day dpcpx day day starting one week mptp injection continuing weeks results therapy caffeine led reversibility movement dysfunction increased concentrations dopamine atp levels also ameliorates dopaminergic neuron loss restored mtdna ndna integrity furthermore passive avoidance test caffeine dpcpx significantly reversed mptp induced memory deficits whereas specific adrsaa antagonist conclusions current results provide evidence blockade adrsa adrsa therapeutic implications alleviating mptp induced motor cognitive dysfunction might promising candidate treatment
issue intensive palliative care patients chronic disease frequently arises review aims describe prognostic factors chronic respiratory diseases instable acute situations order improve management complex situations various laws patients rights provide legal framework define concept unreasonable obstinacy patients chronic obstructive pulmonary disease robust decision factors good knowledge respiratory disease comorbidities history previous exacerbations patient preferences case idiopathic pulmonary fibrosis necessary know prospect transplantation assess reversibility respiratory distress case amyotrophic lateral sclerosis treatment decisions depend presence advance directives use intubation tracheostomy lung cancer patients general condition cancer history tumor treatment plan important factors multidisciplinary discussion takes account patient medical history wishes current state knowledge permits taking coherent decision splf published elsevier masson sas rights reserved
nowadays many applications must process events high rate events processed fly without stored complex event processing technology cep used implement applications cep systems like apache storm popular ceps lack query language operators program queries done traditional relational databases paper presents paas cep cep language provides sql like language program queries cep integration data stores database key value store current implementation done top apache storm however cep language used cep paper describes architecture paas cep query language algebraic operators paper also details integration cep traditional data stores allows correlation live streaming data stored data
paper presents construction elements fertilization biopolitical problem reviewing terms birth control family planning practices medicalization match policies population observed control programs aim describe discursive marks show medicalization practices present advertising guidelines norforms brand medicalization focuses interest expanding control actions life particular case contraceptive ovules visualize strategy creating social disease treatment advocacy campaigns public hygiene article results analysis four mailers brand norforms published magazines circulating bogota years presented discourse analysis concepts biopolitics medicalization recourse provided michel foucault economic political described dynamics population control
years since publication edition classification hematopoietic lymphoid tumours rapid accumulation knowledge molecular genetics biology clinical behavior many hematologic malignancies concepts models advanced point updates deemed necessary prior formal process publication edition part blue book series overview focus lymphoid tumors highlight important changes updates neoplasms
introduction targeted somatic genomic analysis egfr anaplastic lymphoma receptor tyrosine kinase gene alk ros programmed death ligand tumor proportion score tps determined immunohistochemistry ihc used selection first line therapies advanced lung cancer however frequency overlap biomarkers routine clinical practice poorly reported methods retrospectively probed first pairs patients lung adenocarcinoma institution analyzed ihc using clone pharmdx kit agilent technologies santa clara evaluated occurrence genomic aberrations clinicopathologic characteristics results surgical resection specimens small biopsy transbronchial core needle samples cytologic cell blocks needle aspirates pleural fluid tested tps least seen tumors tumors egfr mutations alk fluorescence situ hybridization positivity ros fluorescence situ hybridization positivity tps less versus one tumor tps least tumors tps least significantly associated smoking status compared tumors tps less associated patient sex ethnicity tumor stage biopsy site biopsy type preparation conclusions ihc performed routine clinical lung cancer specimens tps least seldom overlaps presence driver oncogenes approved targeted therapies three biomarker specified groups advanced lung adenocarcinomas defined paired specific palliative first line systemic therapy proven clinical benefit egfr alk ros affected adenocarcinoma paired matched tyrosine kinase inhibitor similar cases enriched adenocarcinoma tps paired anti pembrolizumab similar cases biomarker negative egfr alk ros negative adenocarcinoma paired platinum doublet chemotherapy without bevacizumab similar cases international association study lung cancer published elsevier inc rights reserved
pharmaceuticals routinely detected environment several compounds extensively researched due potential impacts endocrine system aquatic organisms negative reproductive consequences synthetic progestins teleost species recently investigated current study examined different exposure periods may sensitive levonorgestrel lng early life stages fathead minnow larvae larvae exposed single concentration lng different durations fertilized egg days post hatch dph growth mrna expression fsh beta hsd beta hsd cypa measured regardless duration exposure lng significantly decreased growth fathead minnow larvae day beta hsd cypa mrna expression decreased following lng exposure durations days beta hsd fsh showed similar trends exposure lng later stages development exhibiting decreased expression beta hsd beta hsd transcripts remain regulated larvae moved clean water dph lng exposure study first investigate effects exposure time synthetic progestin developing fish future research needed understand impacts changes adult stages development elsevier rights reserved
limbic system central role integration several cognitive visceral functions extended network connections involving hippocampus amygdala number studies performed humans dedicated investigation supratentorial limbic pathways means non invasive mri approaches dti however detection possible limbic connections involving brainstem spinal cord still missing subtentorial limbic pathways previously studied animals means invasive approaches including viral tracing detection limbic connections brainstem spinal cord raised several new hypotheses regarding interaction central nervous system periphery body investigated subtentorial limbic connections twenty one healthy humans means probabilistic constrained spherical deconvolution tractography connectivity analysis showed hippocampus amygdala high probability connections midbrain pons bulb moreover hippocampal amygdalar pathways reaching cervical spinal cord also detected quantitative evaluation diffusion parameters also performed findings present study agreement literature provide first report possible limbic connections brain stem spinal cord human brain since pathways might also important implications physiological pathological contexts studies conducted order confirm data well define functional features brain connections ibro published elsevier ltd rights reserved
objectives patients parkinson disease begin lose weight several years diagnosis suggests weight variation associated factor precede onset motor symptoms study aimed investigate association autonomic nervous system body weight patients materials methods subjects patients early novo examined associations body mass index bmi sympathetic nervous activity reflected orthostatic intolerance cardiac uptake metaiodobenzylguanidine parasympathetic nervous activity reflected constipation heart rate variability hrv results twelve patients overweight bmi patients normal weight bmi patients underweight bmi underweight patients greater disease severity decrease blood pressure head tilt table testing higher cardiac washout ratio metaiodobenzylguanidine lower hrv complained constipation often normal weight overweight patients multiple regression analyses correlation variables bmi maintained statistical significance adjustment age sex symptom duration motor subtype conclusions dysautonomia disease severity closely related body weight independently age sex symptom duration motor subtype dysautonomia may play partial role weight variation early stage
background annexin calcium dependent phospholipid binding protein involved osteogenesis objective present study explore expression annexin spinal ligament tissues ankylosing spondylitis patients determine pathological functions methods mrna protein expression annexin detected real time pcr western blotting respectively interleukin concentration serum assessed enzyme linked immunosorbent assay alkaline phosphatase alp activity measured alp activity kit microplate reader results mrna protein expression annexin concentration serum significantly increased patients moreover exogenous treatment significantly regulated annexin expression alp activity silencing annexin expression significantly ameliorated induced ossification fibroblasts patients indicated alp activity expression proteins associated osteogenic differentiation including bone morphogenetic protein osteocalcin osterix ratio osteoprotegerin receptor activator kappa ligand mek inhibitor experiments suggested annexin may exert function extracellular signal related kinase pathway conclusions annexin regulated may promote ligament ossification patients elsevier masson sas rights reserved
knowledge representation core artificial intelligence research knowledge representation methods include predicate logic semantic network computer programming language database mathematical model graphics language natural language etc establish intrinsic link various knowledge representation methods unified knowledge representation model necessary according ontology system theory control theory standard model knowledge representation reflects change objective world proposed model composed input processing output knowledge representation method contradiction traditional knowledge representation method express knowledge terms multivariate multidimensional also express process knowledge time strong ability solve problems addition standard model knowledge representation provides way solve problems non precision inconsistent knowledge
contribution provides overview optical techniques sound recording sound synthesis sound processing several applications optical devices examples references describing history current trends field given sound recording optical devices used capture vibrations transform mechanical sound waves electrical signal optical storage audio long history beginning analog sound tracks film recent optical media example blue ray disc sound synthesis based optical systems give examples based graphical sound photo sonic disc time domain synthesis frequency domain synthesis techniques controlled time frequency image domain signal representation explained analog sound processing use light emitting diode coupled photo electric cell light dependent resistor constitutes nonlinear two port electrical network element optocouplers still wide range applications switching gating volume control audio signals due special nonlinear behavior hence exists broad interest high quality discrete time models devices overview several applications optical nonlinearities given
new media formats technologies raise questions new found abilities indulge apparently limitless violent sadistic curiosity within culture context mainstreaming sex violence via mobile screen media systems opens important questions degree influences harmful indicative deeper social problems article offer preliminary analysis consequences new media zones acknowledging allure excitement everyday cultural position particular focus distinctive hallmark much online pornography massively popular violent video games offer unchecked encounters others subordinated violent sexual desire suggest key implication zones cultural exception social rules less abandoned role assisting denials harm perspective hyper masculinist militaristic social value systems
magnitudes frequency response functions frfs ambient vibrations seldom investigated necessary basic modal parameter frequency damping mode shape identification however necessary structural flexibility identification article frf magnitudes output data investigated approach identify structural scaled flexibility characteristics proposed first quantitatively formulates relation magnitudes frfs estimated vibration test data known unknown input forces proved magnitude ratios two kinds frfs mode dependent way calculate magnitude ratios proposed scale frfs output data finally closed form solution scaled flexibility derived ambient vibration data identified scaled flexibility reveal load deflection characteristics structure engineers standing structure safety condition numerical experimental examples illustrate effectiveness scaled flexibility identification theory elsevier ltd rights reserved
background computed tomography examinations lumbar spine commonly performed patients aged years due low back pain lbp purpose investigate prevalence awareness radiologists presence structural post inflammatory sacroiliac joint sij alterations lumbar spine cts young patients lbp material methods total lumbar spine ctexaminations men women average age years age range years patients lbp entire sijs visualized retrospectively reviewed sijs scored consensus two senior radiologists study reading presence post inflammatory structural sij findings sijs alterations original reports compared study reading fifty examinations evaluated reliability assessment intra class correlation coefficient icc results total abnormal sij examinations registered icc suspected sacroiliitis definite sacroiliitis osteitis condensans ilii diffuse idiopathic skeletal hyperostosis degenerative changes accessory sij tumor sijs referenced times original readings pathological findings normal sij total diagnostic accuracy reports entire readings respectively respectively pathological findings conclusion sacroiliitis sij alterations prevalent young individuals lbp albeit majority alterations recognized reported senior radiologists thus may delay efficacious treatment
objectiveto determine whether headache disorders risk factor development new onset hypothyroidism backgroundpast studies reported associations headache disorders hypothyroidism directionality association unknown methodsthis longitudinal retrospective cohort study using data fernald medical monitoring program fmmp residents received physical examinations thyroid function testing every years year program residents excluded cohort evidence past thyroid disease abnormal thyroid function tests first office visit diagnosis headache disorder established self report frequent headaches use headache specific medication physician diagnosis headache disorder primary outcome measure new onset hypothyroidism defined initiation thyroid replacement therapy tsh without thyroid medication cox survival analysis time dependent variables used model headache disorders age sex body mass index income smoking narcotic use hypothyroidism producing medications independent variables model resultsdata residents enrolled fmmp used current study headache disorders present residents new onset hypothyroidism developed approximate hazard ratio development new onset hypothyroidism headache disorders conclusionsheadache disorders may associated increased risk development new onset hypothyroidism
haemodynamic responses spreading depolarizations sds important role development secondary brain damage characterization haemodynamic responses larger brains however difficult due movement artefacts intrinsic optical signal ios imaging laser speckle flowmetry lsf electrocorticography performed different configurations three groups total swine sds elicited topical application kcl occurred spontaneously middle cerebral artery occlusion movement artefacts ios compensated elastic registration algorithm post processing using movement compensated ios able differentiate four components optical changes corresponding closely haemodynamic variations measured lsf compared ecog lsf setup provides higher spatial temporal resolution well better signal noise ratio using ios alone could identify different zones infarction large gyrencephalic middle cerebral artery occlusion pig model strongly suggest movement compensated ios investigation role haemodynamic responses sds development secondary brain damage particular examine effect potential therapeutic interventions gyrencephalic brains
study aimed determine prevalence clinical correlates adverse childhood experiences aces among inpatient youths two types severe psychiatric disorders aces retrospectively collected aces scale list threatening experiences questionnaire patients hospitalized catatonic syndrome average age years manic mixed episode average age years aces frequent youths suffering bipolar disorder type catatonia around one quarter exposed severe abuse physical sexual emotional abuse physical emotional neglect youths likely exposed family violence compared catatonia youths exposed aces exhibit severe presentation poorer response treatment compared others either bipolar group catatonic group
paper present learning based detection highly challenging specular object exposed direct sunlight close range object detection one important areas image processing also used initialization local visual tracking methods object detection space generally difficult problem poses difficulties object specular exposed direct sunlight space environment solution problem relies appearance learning real satellite mock based vector quantization vocabulary tree method implemented standard computer cpu exploits full perspective projection model provides near real time pose detection satellite close range approach manipulation time consuming part training feature description building vocabulary tree indexing depth buffering back projection performed offline fast image retrieval registration performed line contrast state art image based pose detection methods slower cpu assume weak perspective camera projection model case dimension satellite larger distance camera hence assumption weak perspective model hold evaluate proposed method appearance full scale mock rear part terrasar satellite trained various illumination camera views training images captured camera mounted six degrees freedom robot enables position camera desired view sampled sphere views within workspace robot interpolated using image based rendering moreover generate ground truth poses verify accuracy detection algorithm achieved results robust accurate even noise due specular reflection able initialize local tracking method international society photogrammetry remote sensing inc isprs published elsevier rights reserved
arteriovenous malformations common cause spontaneous intracerebral hemorrhages older children intracerebral hematoma cause serious lasting neurologic cognitive language deficits even possible death present case year old boy language impairments suffering large hemorrhagic stroke left temporoparietal region language components verbal nonverbal communication reading writing found affected impairments expected characteristic location hematoma year speech language rehabilitation almost complete recovery language skills quick diagnosis adequate therapeutic interventions important diminish influence intracerebral hemorrhage cognitive language functions children
background aim women homozygous mutation hfe gene much lower risk iron overload related disease homozygous men presumably iron depleting effects menstruation pregnancy used data population cohort study model impact menstruation cessation menopause serum ferritin levels female homozygotes simple compound heterozygotes neither mutations hfe wild types comparison groups methods sample melbourne collaborative cohort study selected healthiron study including hfe homozygotes plus random sample stratified hfe genotype relationship natural logarithm time since menopause examined using linear mixed models incorporating spline smoothing results homozygotes increased factor first years postmenopause continued increase less half previous rate contrast profiles hfe genotype groups increase gradually show distinction premenopausal postmenopausal levels homozygotes predicted exceeding postmenopause projected increase risk iron overload related disease conclusions data provide first documented evidence physiological blood loss major factor determining marked gender difference expression homozygosity
metal selenides proposed counter electrodes ces substitute dye sensitized solar cells dsscs due good catalytic activity reduction triiodide paper nise nanoparticles synthesized facile room temperature process used ces order enhance photovoltaic property graphene introduced facile physical mixing eventually assistance graphene nise graphene exhibited better power conversion efficiency pce compared elsevier rights reserved
completed hardanger bridge longest suspension bridge norway among slender suspension bridges world context extensive research project initiated norwegian public roads administration bridge installed comprehensive monitoring system investigate wind characteristics site along dynamic response bridge wind velocities measured using nine anemometers installed different locations bridge span representative min recording high mean wind velocity perpendicular wind direction selected present preliminary results time series turbulence components one point spectra presented spatial properties wind field studied examining coherences turbulence components several separation distances dynamic response bridge measured using accelerometers distributed along main span time histories accelerations well response spectra presented relationship bridge vibrations wind measurements discussed
purpose nocturia associated poor sleep quality however little known relationship nocturia sleep quality across different workforce relevant age groups adults implications developing new treatment strategies well tolerated across populations methods conducted cross sectional study involving merged data waves national health nutrition examination survey participants responded validated questions nocturia frequency sleep functional outcomes sleep questionnaire general productivity subscale fosq range analyses included multivariable linear regression stratification gender examine associations nocturia frequency higher worse fosq scores lower scores indicating worse daytime function related sleep disturbance findings adults aged years completed survey complete nocturia fosq data population age adjusted prevalence nocturia least twice nightly among men among women nocturia increased age years greater nocturia frequency reported worse fosq scores compared younger adults similar nocturia frequency among men women implications population based sample community dwelling men women association nocturia worsened functional outcomes sleep greater among adults older years group vulnerable drug side effects nocturia typically multifactorial additionally analyses found association nocturia functional outcomes sleep stronger increasing age among men effective treatment strategies well tolerated older adults multicomponent treatments simultaneously address combined effects lower urinary tract sleep dysfunction needed published elsevier journals inc
objectives invasive fungal infections ifis cause significant morbidity mortality among recipients hematopoietic stem cell transplantation hsct although fluconazole used widely antifungal prophylactic agent patients reliably effective mold infection including invasive aspergillosis micafungin provides antifungal activity candida aspergillus species previous studies demonstrated efficacy used prophylactic agent fungal infection neutropenic patients evaluated compared incidence proven probable ifis antifungal prophylaxis using micafungin fluconazole methods prospective single center phase study involving adult patients received allogeneic autologous hsct patients randomly assigned micafungin fluconazole arms ratio treatment initiated within hsct maintained days primary end point incidence proven probable ifis days hsct secondary end points incidence rates possible proven probable ifis need change antifungal agent engraftment ifi related mortality survival within days transplantation results march may total patients enrolled exclusion seven patients receive least one dose study treatment patients micafungin fluconazole included analysis clinical efficacy median age years range allogeneic autologous transplantations performed patients respectively baseline characteristics well balanced two groups overall incidence proven probable ifis within days hsct percentages patients experienced proven probable ifis differ significantly micafungin fluconazole groups respectively thirteen patients micafungin arm eight patients fluconazole arm needed change antifungal agent engraftment mortality within days hsct differ significantly groups micafungin fluconazole arms respectively conclusion micafungin comparable fluconazole prevention ifis hsct recipients published elsevier ltd behalf british infection association
engine gas exchange processes characterized overall parameters volumetric efficiency important parameters depends addition fuel operating variables design manifolds valves ports engine moreover gas dynamics flowing gases including pressure waves boundary layer thickness flow due friction play important role smart device fitted exhaust pipe used improve engine volumetric efficiency power fuel economy controlling valve takes commands depending engine loading conditions signals sensors manifold air pressure engine speed air mass flow inlet air temperature hence suitable amount air fuel flow achieves optimum performance conditions furthermore work also intended develop neuro fuzzy controller model improving performance spark ignition engine sie fitted smart device experiments carried cylinder displacement volume mitsubishi engine using pid controller full range road load test conditions covered hydraulic dynamometer used addition scan tool exhaust gas analyzer obtained results show using smart device improves power bsfc load whereas neuro fuzzy based controller enhances engine power reduction brake specific fuel consumption comparison pid controller used basic engine energy institute published elsevier ltd rights reserved
pseudofungi septate hyphae like structures similar morphologically true fungal elements histologically presence poses diagnostic challenge mimic fungal infection accurate identification pseudofungi required avoid unnecessary treatment accomplished careful morphologic analysis use appropriate histochemical stains report patient pseudofungi within paratracheal lymph node describe morphologic findings discuss differential diagnosis
nutrients known significant role maintaining health skeleton bone cartilage nutrients received majority attention vitamin calcium however limited attention directed toward three trace elements may mechanistic impact upon skeletal tissues could compromise skeletal health resulting inadequate intakes copper iron selenium role copper selenium known role iron received recent attention copper deficiency thought impact bone health decrease lysyl oxidase copper containing enzyme facilitates collagen fibril crosslinking iron deficiency impact upon bone recently discovered exact mechanism deficient states enhance bone pathology speculative selenium deficiency impact cartilage thereby indirect impact bone however several studies suggest mycotoxin consumed humans culprit cartilage disorders presence selenium could attenuate pathology review summarizes current knowledge base respect skeletal integrity three trace elements inadequate diets animals humans
posttraumatic stress disorder ptsd common undertreated among veterans affairs primary care patients brief primary care intervention combining clinician support self management mobile app clinician supported ptsd coach csptsd coach may improve patient outcomes study developed refined intervention provide clinician support facilitate use ptsd coach app gathered provider patient qualitative quantitative feedback ptsd coach investigate preliminary acceptability implementation barriers facilitators primary care providers mental health leadership completed survey interview regarding implementation barriers facilitators structured according consolidated framework implementation research cfir clinicians delivered ptsd coach patients received provided feedback intervention implementation process ptsd coach high provider patient acceptability important implementation factors included ptsd coach compatible clinics current practices low complexity implement perceived address patient needs strong support leadership diverse factors related ptsd coach delivery facilitate implementation provide opportunity problem solve barriers improve integration intervention primary care
review frequency anti tnf alpha loses effect dose intensification required crohn disease treatment electronic databases searched eligible studies raw data studies meeting inclusion criteria pooled effect estimates subgroup analyses performed exploration heterogeneity regarding outcomes eighty six eligible studies included estimates loss response lor incidence ranged random effects pooled incidence lor median follow year studies effect estimate based data patients infliximab adalimumab certolizumabpegol overall mean percentage patients lor anti tnfs annual risk lor per patient year random effects pooled rate need dose intensification median follow year studies effect estimate infliximab adalimumab certolizumab pegol mean percentage patients needed anti tnf dose escalation annual risk per patient year evidence publication bias incidence lor dose intensification overall around one third patients experience lor required dose intensification primary anti tnf alpha responders
consider variable metric linesearch based proximal gradient method minimization sum smooth possibly nonconvex function plus convex possibly nonsmooth term prove convergence iterative algorithm critical point objective function satisfies kurdyka lojasiewicz property point domain assumption limit point exists proposed method applied wide collection image processing problems numerical tests show algorithm results flexible robust competitive compared recently proposed approaches able address optimization problems arising considered applications
game development interdisciplinary concept embraces artistic software engineering management business disciplines research facilitates better understanding important dimensions digital game development methodology game development considered one complex tasks software engineering increased popularity digital games challenges faced game development organizations developing quality games high competition digital game industry demand game development maturity assessment consequently study presents digital game maturity model evaluate current development methodology organization framework model consists assessment questionnaires performance scale rating method main goal questionnaires collect information current processes practices general research contributes towards formulating comprehensive unified strategy game development maturity evaluation two case studies conducted assessment results reported demonstrate level maturity current development practices two organizations elsevier rights reserved
objective assess differential features marrow adiposity osteoarthritis osteoporosis postmenopausal women using water fat mri methods cross sectional study included postmenopausal women osteopenia groups water fat mri dual energy ray absorptiometry biochemical analysis performed assess vertebral marrow fat fraction bone mineral density bone biomarkers respectively harris hip score recorded evaluate hip function results significant differences marrow fat content among osteopenia groups participants normal bone mass osteopenia significant difference observed groups serum levels leptin beta crosslaps normal bone mass osteopenic groups higher group marrow fat fraction inversely correlated harris hip score bone mineral density leptin levels multivariate regression analysis marrow fat fraction found consistent unchanged inverse association leptin levels beta bone mineral density beta adjusting age years since menopause body mass index conclusions postmenopausal phenotype higher marrow adiposity could coexist presence specific subgroup increased marrow fat accumulation high risk developing
recent years model order reduction mor interconnect system become important technique reduce computation complexity improve verification efficiency nanometer vlsi design krylov subspaces techniques existing mor methods efficient become methods choice generating small scale macro models large scale multi port rcl networks arise vlsi interconnect analysis although krylov subspace projection based mor methods widely studied past decade electrical computer aided design community provide best optimal solution given order paper minimum norm least squares solution mor krylov subspace methods proposed method based generalized inverse pseudo inverse theory enables new criterion mor based krylov subspace projection methods two numerical examples used test prima method based method proposed paper standard model
three dimensional printing printing additive manufacturing promising approach construction small sized complex structures microelectromechanical systems mems paper reports design fabrication testing nanopositioning flexure made titanium alloy created first time electron beam melting ebm also known electron beam additive manufacturing ebam titanium alloys present attractive characteristics including high biocompatibility distinct strength corrosion resistance however difficult machine titanium alloys conventional processes use additive manufacturing enabled build multidimensional nanopositioning flexure amplified mechanical displacement improved bandwidth contained compact structure first characterized mechanical properties ebm printed cantilevers compared results bulk metal cantilevers due porous surfaces printed cantilevers acted softer material averaged young modulus gpa considering outermost dimensions introducing inner widths cad designed beam width calculated young modulus gpa comparable gpa reported literature bulk completion initial characterization fabrication flexure undergone successfully carried mechanical levers printed within flexure amplified actuation piezoelectric actuator factor six displace positioning platform supported network parallel supporting beams maximum displacement obtained driving voltage resonant frequencies measured axes almost identical respectively digital pid controller enabled laser based dynamic positioning stage triangular sweeps positioning error within time delays respectively elsevier rights reserved
purpose review growing interest neuromodulation primary headache conditions invasive modalities occipital nerve stimulation deep brain stimulation sphenopalatine ganglion stimulation reserved severe intractable patients non invasive options vagal nerve stimulation nvns supraorbital nerve stimulation nsons transcranial magnetic nerve stimulation tms emerged potentially useful headache treatments review examines evidence base non invasive neuromodulation trigeminal autonomic cephalalgias migraine recent findings although number open label series non invasive neuromodulation devices published little controlled evidence use headache condition open label evidence suggests nvns may role prophylactic treatment cluster headache limited evidence suggest may useful acute treatment cluster potentially migraine attacks limited controlled evidence suggest role nsons prophylactic treatment episodic migraine evidence support use cluster headache tms may efficacious acute treatment episodic migraine controlled evidence support use preventative headache condition summary non invasive neuromodulation techniques attractive treatment option excellent safety profiles use yet supported high quality randomised controlled trials
study objectives examine sleep health knowledge beliefs relationship sleep practices community sample caregivers young children methods convenience sample caregivers visiting museum one consecutive weekend days completed brief parent report survey child sleep habits parental basic sleep knowledge beliefs attitudes regarding sleep health behavior results analyzable surveys response rate mean age index child years children consistent bedtime bedtime later least one electronic device bedroom frequently fell asleep adult present positive negative sleep habits tended cluster together children irregular late bedtimes twice likely obtain insufficient sleep regular early bedtimes children getting less recommended sleep amount age parents believed child getting insufficient sleep lack knowledge regarding potential negative impact specific sleep practices associated increased likelihood engaging practices conclusions results survey study generally well educated sample caregivers suggest clear parental knowledge gaps regarding healthy sleep young children supports need increased sleep health education
paper requirements models methods tools support servitisation collaboration manufacturing enterprises service providers addressed manufacturing service ecosystem msee european project applied novel approach elicit requirements aims fulfil establishing manufacturing service ecosystems mse concept identifying specifying requirements support msee developed models methods tools realise products services virtual enterprises established mse validated four european test cases
secondary data analysis examined association head start children entry age enrollment duration children dental vision hearing health based data local head start classrooms children divided three groups one group children entered head start age three maintained enrollment one year group second group children entered head start age four stayed one year group third group children entered age three stayed head start two years group compared group group fewer dental problems group less identified hearing problems children gender ethnicity program characteristics family risk factors associated health problems
objective assess quality information internet regarding plan yuzpe method copper intrauterine device iud study design internet search performed using common search engines terms morning pill emergency contraception plan first websites generated search evaluated websites excluded informational sites descriptive analysis performed results fifty one websites unique relevant study criteria majority sites reported plan taken within hours unprotected intercourse could obtained without prescription yuzpe method copper iud less likely mentioned though information presented tended accurate conclusion majority information regarding emergency contraception internet accurate suggesting internet could used increase emergency contraceptive knowledge patients
study objectives despite several polysomnographic normative studies multiple surveys sleep disorders general population data collected healthy sleepers aimed survey characteristics healthy sleep methods prospectively investigated sleep history subjects representative population sample reported undisturbed sleep relevant sleep disorders ruled two step screening procedure approximately four subjects contacted identifying eligible subject participated results median reported time bed total sleep duration varying age group years median sleep efficiency high range fifty one subjects reported occasional snoring forty five subjects reported sporadic non bothersome sleep related movement disorders sleep related leg cramps lifetime bruxism restless legs syndrome history sporadic non bothersome parasomnias nightmares sleepwalking sleep paralysis conclusion population healthy sleepers snoring common finding moreover non bothersome forms recognizable sleep related movement disorders parasomnias surprisingly common findings may suggest diagnostic criteria sleep disorders based presence symptoms also account minimum frequency discomfort
regularization appeared explicitly hyperspectral image hsi classification community serves promising paradigm leveraging labeled unlabeled information computer automation user interaction spectral spatial information graph based regularization capable modeling nonlinear structures embedded high dimensional space great potential hsi classification however traditional methods exhibit low capacity facing noisy large scale data thus posing big challenge successful use community paper present two novel sparse graph regularization methods sgr sgr total variation sgr sgr labels large unknown data propagated based fraction matrix prediction function fraction matrix obtained using effective sparse representation algorithm respect dictionary prediction function estimated optimizing typical graph based regularization problem contrast sgr extension sgr considering spatial information modeled total variation propagating prediction function dictionary large unknown data using fraction matrix essence paradigm sgr sgr equipped semisupervised learning active learning spectral spatial classification large flexibility experimental results two popular hyperspectral data sets indicate proposed methods outperform state art approaches terms computational efficacy classification accuracy robustness noise
paper presents application fractional order controller control multi input multi output twin rotor aerodynamic system dynamics considered system highly nonlinear exists significant cross coupling horizontal vertical axes pitch yaw paper fractional order model twin rotor aerodynamic system identified using input output data nonlinear system based upon identified fractional order model fractional order pid controller designed control angular position level bar twin rotor aerodynamic system parameters controller tuned using nelder mead optimization compared particle swarm optimization techniques simulation results nonlinear model show significant improvement performance fractional order pid controller compared classical pid controller
background hereditary angioedema caused inhibitor deficiency inh hae rare autosomal dominant disorder inh hae characterized edema formation may occur response stress individual response stress stimuli partly genetically determined activation hypothalamic pituitary adrenal axis results release cortisol turn secreted gluco mineralocorticoids affect metabolism well cardiovascular immune systems hypothesized changes serum cortisol level polymorphisms glucocorticoid receptor modify individual sensitivity stressor stimuli inh hae patients results compared response stress rahe brief stress coping inventory inh hae patients angioedema patients healthy controls inh hae patients healthy controls genotyped glucocorticoid receptor polymorphisms bcli serum cortisol levels determined attacks symptom free periods inh hae patients relationships clinical laboratory data snps single nucleotide polymorphisms assessed using anova inh hae patients decreased coping capabilities compared healthy controls cortisol levels significantly higher attacks symptom free periods magnitude elevation cortisol levels show significant correlation clinical laboratory data among inh hae patients carriers allele significantly lower cortisol levels increased body mass index compared non carriers conclusions higher cortisol level observed attacks may reflect effect stressful situation attack patients neuroendocrine system carriers lower cortisol levels might reflect altered feedback hypothalamic pituitary adrenal axis due decreased sensitivity glucocorticoids
objective advanced paternal age apa conception linked autism schizophrenia offspring neurodevelopmental disorders affect social functioning current study explored effects paternal age social development general population method used multilevel growth modeling investigate apa effects socioemotional development early childhood adolescence measured strengths difficulties questionnaire sdq twins early development study teds sample also investigated genetic environmental underpinnings paternal age effects development using additive genetics common environment unique environment ace gene environment gxe models results general population young advanced paternal ages associated altered trajectory social development intercept slope behavioral domain affected either young advanced age fatherhood suggesting specificity paternal age effects increased importance genetic factors social development recorded offspring older young fathers suggesting distinct underpinnings paternal age effects two extremes conclusion findings highlight apa related deficits lead autism schizophrenia likely continuously distributed population
paper reflective exploration emotional encounter social workers irish travellers child safeguarding cases unconscious defences may triggered social workers unfamiliar travellers impact relationship outcomes raises concern pervasive societal disapproval towards travellers may absorbed social workers expense curiosity historic marginalisation contemporary cultural social context recognition strengths community drawing psychoanalytical insights race comprises literature review highlights themes marginalisation research irish travellers also includes narrative interview traveller woman reflects fear social workers invoke travellers sets key question might emotional state social worker scenario
italy dealing iodine deficiency since ancient times hoc committee appointed king sardinia identified extensive areas afflicted endemic goiter endemic cretinism piedmont liguria sardinia since many epidemiological studies conducted country showed iodine deficiency present mountain areas also coastal areas iodization salt allowed law iodized salt distributed request selected endemic areas five years later distribution extended whole country however sale iodized salt mandatory time small fraction italian population started using iodized salt content iodine salt raised nationwide salt iodization program finally implemented years later nationwide monitoring program iodine prophylaxis also implemented since sale iodized salt italian supermarkets increased although observed use iodized salt still low communal eating areas food industry data coherent recent epidemiological studies showing regions country still characterized mild iodine deficiency high frequency goiter iodine deficiency disorders implies efforts made successfully correct iodine deficiency italy
explain share photons two distant parties using concatenated entanglement swapping assess performance according two photon visibility figure merit analysis readily see key generation rate quantum bit error rate figures merit scheme applied quantum key distribution qkd model accounts practical limitations including higher order photon pair events dark counts detector inefficiency photon losses analysis shows compromises needed among runtimes experiment rate producing photon pairs choice detector efficiency quantitative results observe concatenated entanglement swapping enables secure qkd long distances key generation rates far low useful large separations find key generation rates close takeoka guha wilde pirandola laurenza ottaviani banchi bounds society photo optical instrumentation engineers spie
paper investigate effectiveness two stage classification strategies detecting north atlantic right whale upcalls time frequency measurements data passive acoustic monitoring devices evaluated images vocalization spectrograms preprocessed noise reduction tone removal first stage algorithm eliminates non upcalls energy detection algorithm second stage two sets features extracted remaining signals using contour based texture based methods former based extraction time frequency features upcall contours latter employs local binary pattern operator extract distinguishing texture features upcalls subsequently evaluation phase carried using several classifiers assess effectiveness contour based texture based features upcall detection comparing roc curves machine learning algorithms obtained cornell university dataset reveals lbp features improved performance accuracy time frequency features classifiers linear discriminant analysis support vector machine treebagger achieve highest upcall detection rates lbp features elsevier ltd rights reserved
importance attach perception light colour emotional effects discussed reference experimental work question whether red activating colour blue discussed reference two opposing schools thought one based colour light measured physiological changes central autonomic nervous system based colour pigment applied interior exterior spaces question whether colour affects subjective estimation time warmth also discussed reference experimental work ongoing debate colour aesthetics particular colour preferences discussed longitudinal basis past years teaching subject oxford school architecture
nursing clinics rheumatology ncr organizational care models provide care centred within scope nurses abilities analyse patients differences knowledge disease adherence treatment quality indicators rheumatology departments included quality perceived patients without ncr national multicenter observational prospective cohort study year follow comparing patients attending rheumatology services without ncr ncr defined presence office least one dedicated nurse appointment schedule phone variables included baseline months batalla haynes sackett morisky green quality perceived tests addition another specific questionnaire drawn collect healthcare teaching research activities rheumatology department total patients included ncr ncr corresponding units ncr without ncr age years significant differences favour ncr group found haynes sackett morisky green tests basal visit significant differences found questions courtesy kindness received nurse good good greater proportion ncr group publications last years significantly higher ncr group national international journals higher research activity quality perceived patients observed rheumatology departments ncr
objective case report describes forensic psychiatric patient presenting treatment resistant schizophrenia serious interpersonal violence complicated poor adherence oral medication treated successfully two concurrent long acting depot antipsychotics method treatment response measured month period weekly intervals post initiation using positive negative symptoms schizophrenia excited component score panss brief psychiatric rating scale bprs clinical global impression scale cgi results months presentation found markedly improved overall panss score reduced reductions positive symptom excited component subscales evident bprs score reduced baseline weeks improvement patient level cooperativeness aggression engagement ward therapeutic activities conclusion although concurrent use two depot antipsychotics requires exploration potential benefit patient groups presenting treatment resistant schizophrenia poor compliance due risk serious adverse effects difficult reverse long acting formulations recommend option reserved complex patient population exclusively care settings allowing close physical health monitoring
potential mechanical lamination timber bridge construction application developing structural uses low grade grown timber investigated mechanically laminated pedestrian bridge designed half scale span bridge subjected series experimental analytical investigations flat stress laminated timber deck formed transversely post tensioning short timber planks steel bars resulting orthotropic solid plate suspended two screw laminated slender timber arches timber predominately acts compression end bearing butt ends structure subjected series deck loading conditions failure loads bridge behaves elastically well beyond design load shows high level ductility recovery capacity failure structure arises lateral instability arches symmetrical deck loading commercial finite element analysis programme used predict behaviour structure close agreement analytical experimental results demonstrates structural performance mechanically laminated timber structures reasonably accurately predicted using linear elastic analysis study also shows relatively large span stiff strong structures constructed using means short lengths low quality timber
exogenous oxytocin administration widely reported improve social cognition human nonhuman primate adults risk factors impaired social cognition however emerge infancy early interventions plasticity greatest critical reverse negative outcomes tested hypothesis oxytocin may exert similar positive effects infant social cognition adults test idea assessed effectiveness acute aerosolized oxytocin two foundational social cognitive skills working memory ability briefly hold process information social gaze tracking direction others gaze month old nursery reared macaque monkeys macaca mulatta predict sex differences included sex factor analyses test whether effects would generalizable across males females double blind placebo controlled design found females socially skilled baseline compared males oxytocin improved working memory gaze following males sex differences unexpected may due interactions gonadal steroids may relevant sexually dimorphic disorders social cognition male biased autism spectrum disorder oxytocin proposed potential treatment sum report first evidence oxytocin may influence primate infant cognitive abilities moreover behavioral effects appear sexually dimorphic highlighting importance considering sex differences oxytocin effects observed one sex may generalizable sex
two phase gas solids transport models widely utilized process design automation broad range industrial applications applications include proppant transport gaseous fracking fluids air gas drilling hydraulics coal gasification reactors food processing units systems automation real time process optimization stand benefit great deal availability efficient accurate theoretical models operations data processing however modeling two phase pneumatic transport systems accurately requires comprehensive understanding gas solids flow behavior study discuss prevailing flow conditions present low fidelity two fluid model equation particulate transport model equations formulated manner ensures physical flux term remains conservative despite inclusion solids normal stress empirical formula modulus elasticity new set roe pike averages presented resulting strictly hyperbolic flux term system equations used develop roe type approximate riemann solver resulting scheme stable regardless choice flux limiter model evaluated prediction experimental results pneumatic riser air drilling hydraulics systems demonstrate effect impact numerical formulation choice numerical scheme model predictions illustrate capability low fidelity one dimensional two fluid model predicting relevant flow parameters two phase particulate systems accurately even flow regimes involving counter current flow elsevier inc rights reserved
case based reasoning cbr widely adopted construction management research due similar mind sets cbr problem solving however date systematic review cbr applications previous studies raising question current status quo cbr applications research using method content analysis study provides comprehensive literature review cbr articles published january found popularity cbr applications research increasing especially majority emanating south korea addition cbr application fields identified primary research interests focusing construction cost estimation construction tendering bidding procurement environment sustainability management issues previous cbr model developments also identified mainly related model hypothesis testing reuse case outcomes selection model development methods use derivational analogy automated implementation together future research suggestions directions study helps provide academics practitioners comprehensive understanding development cbr applications implications future studies elsevier rights reserved
calcium pyrophosphate deposition disease cpdd type arthritis caused deposition calcium pyrophosphate crystals may present either acute chronic arthritis development cppd crystal deposition disease young people may associated metabolic diseases hemochromatosis hyperparathyroidism hypomagnesemia wilson disease hypothyroidism gout acromegaly linked hypophosphatemic rickets therefore investigations predisposing metabolic condition advised young onset polyarticular cppd crystal deposition disease article report two young patients investigated recurrent joint pain due cppd disease
work addresses potential waste energy recovery exhaust gases diesel passenger car mounted chassis dynamometer new european driving cycle followed recording relevant operating variables tests performed three temperature conditions exergy analysis included find potential exhaust gases produce useful work six points exhaust system results include mean temperature point well energy quality index lower meaning less one third energy exhaust gases converted useful work recovery system general highest exergy losses found muffler although greatest recovery potential corresponds highest temperature gases environmental regulations vehicles restrict waste energy recovery performed downstream treatment devices present work outlet diesel particle filter temperature gases location varied range degrees potential fuel saving varied complete driving cycle elsevier ltd rights reserved
report first time literature method synthesize hydrophobic superhydrophobic concrete concrete normally hydrophilic material significantly reduces durability concrete structures pavements synthesize water repellent concrete hydrophobic emulsions fabricated applied portland cement mortar tiles emulsion enriched polymethyl hydrogen siloxane oil hydrophobic agent well metakaolin silica fume induce microroughness polyvinyl alcohol pva fibers create hierarchical surfaces various emulsion types investigated using different mixing procedures single double layer hydrophobic coatings applied emulsions coatings characterized optical microscope scanning electron microscope sem wetting properties including water contact angle roll angle measured theoretical model coated non coated concrete generalized types materials developed predict effect surface roughness composition optimized distance aggregates found highest value maximal measured specimen pva fibers treated based emulsion since water penetration main factor leading concrete deterioration hydrophobic water repellent concretes much longer durability regular concretes broad range applications civil materials engineering
theoretical impedance relationships limiting process non steady state surface diffusion derived based interfacial conductivity concept interface oxygen ion conductor metallic electrode non steady state surface diffusion adsorbed neutral oxygen metallic electrode could described fick second law approximated equivalent equations warburg impedance gerischer impedance derived according boundary conditions occurrence dissipation chemical reaction diffusion related electrochemical impedance signal diffusion oxygen ions addition necessary assume electrochemical potential gradient profile free electrons metallic electrode relationships obtained paper indicate electrochemical potential measured instrument clearly defined electrochemical potential free electrons triple phase boundary meaning equivalent electrical circuits corresponding impedance spectra reconsidered view points interfacial conductivity concept crown copyright published elsevier rights reserved
conventional shaping mehod tire curing depends bladder high elasticity low rigidity determine tire cavity profile inevitably difficult aquire high uniform mass distribution leads low product manufacturing precision low dynamic balance tire meanwhile conventional tire curing process defects low heat transfer efficiency geat useless consumption adopts steam water heat green tire especially tire cavity indirectly obtains themal energy bladder low thermal conductivity new generation tire energy saving curing precision manufacturing technology expected authors paper developed kind curing technology direct pressure shaping inner mould tire complete plants controlled telescopic metal mould high rigidity high heat conductivity replaces bladder electromagnetic induction heating applid curing process thoroughly abandons conventional heating mediums intelligent digital control curing procedure realized provide new approach curing saving precision manufacturing high performance tire product trial manufacture carrid tire experimental results show uniformity dynamic balance tire respectively increases utility cost saves curing process
investigation paper nonisospectral variable coefficient fifth order korteweg vries equation fluids virtue bell polynomials symbolic computation bilinear form backlund transformation lax pair obtained based bilinear form soliton solutions constructed furthermore periodic wave breather wave solutions obtained virtue riemann theta function homoclinic test approach respectively addition characteristic line method applied discuss features solitons nonisospectral problem amplitude velocity width solitary wave elsevier ltd rights reserved
propose simulation algorithm non causal vector autoregressive moving average varma processes algorithm based jordan canonical form companion matrix state space representation illustrate performance non causal varma process elsevier rights reserved
study examined relationships individual differences spirituality measured daily spiritual experience dse scale temporal dynamics transcendental positive emotions using event sampling participants rated emotions repeatedly min intervals days found higher dse associated higher variability instability transcendental positive emotions min intervals also higher dse associated higher inertia transcendental positive emotions greater switch negative emotions transcendental positive emotions across days importantly relationships independent five factor model personality constructs generally replicated emotions also independent temporal dynamics emotions article discusses among issues findings might mean well implications spirituality
background within context support program smoking cessation initiated turkish ministry health present smoking cessation centres found suitable pharmacological treatment given varenicline bupropion free charge smoking cessation programme centralized selection medication made randomly provide fixed distribution rate aim study evaluate efficacy varenicline bupropion smoking cessation evaluate effect smoking cessation programme methods total individuals met study criteria included study smoking habits degree dependence determined participants fagerstrom test nicotine dependence ftnd bupropion varenicline therapy initiated eligible patients followed days months smoking cessation level ppm point prevalence abstinence used criteria success smoking cessation evaluation showed non smoking status previous days results mean age participants years male participants given varenicline bupropion mean ftnd package year significantly different groups rates success weeks months significantly higher varenicline group bupropion group end one year rate smoking cessation determined varenicline group bupropion gruop difference statistically significant end year previous days smoking status evaluated point prevalence abstinence measurement success criteria success rates varenicline bupropion difference significant individuals used medications days longer successful smoking cessation common reasons given discontinuing medication side effects significant difference determined groups respect side effects observed conclusions although rates smoking cessation control points higher varenicline bupropion significant difference found success rates varenicline bupropion used smoking cessation based last days end one year used medications days longer successful smoking cessation
developing highly active photocatalysts water treatment vital importance large mesopore hierarchical hydrate photocatalyst exposed high energy facets synthesized via facile hydrothermal method using sodium chloride structure directing agent forming model hierarchical structure discussed photogenerated oxide species investigated shown orthorhombic center dot photocatalyst hierarchical structure assembled various dimension nanosheets average pore diameter reaches approximately besides could decompose rhodamine visible light irradiation within four hours enhanced photocatalytic efficiency attributed exposed high energy crystal facets hierarchical structure large mesopores existing crossed nanosheets help charge carriers separation adsorption reactants desorption product molecules furthermore catalyst displays excellent photocatalytic stability indicating broad application water pollution treatment elsevier ltd rights reserved
hypothyroidism associated development non alcoholic steatohepatitis cellular mechanisms scarcely analyzed thyroid hormones regulate synthesis secretion bile acids endogenous ligands farnesoid receptor fxr alpha involved development non alcoholic steatohepatitis however relationship thyroid hormones fxr alpha expression liver yet unknown control methimazole induced hypothyroid female rabbits used evaluate amount lipids glycogen vascularization hepatocytes proliferation immune cells infiltration expression fxr alpha student mann whitney tests carried determine significant differences hypothyroidism induced steatosis glycogen loss fibrosis minor vascularization liver contrast hypothyroidism increased proliferation hepatocytes infiltration mast cells modify number immune cells sinusoids changes associated minor anti fxr alpha immunoreactivity periportal hepatocytes pericentral immune cells results suggest hypothyroidism induces moderate non alcoholic steatohepatitis alllowing hepatic regeneration fxr alpha may involved development non alcoholic steatohepatitis hypothyroid subjects
letter global navigation satellite system reflectometry gnss delay doppler maps ddms acquired techdemosat tds mission analyzed identify sea ice infesting waters circumpolar areas first sensitivity actual ddm sea ice investigated using reference information provided sentinel synthetic aperture radar imagery special sensor microwave imager based sea ice concentration map new product proposed consists normalized radar cross section measurements derived actual ddms arranged gridded format product shown provide spatial information sea ice transition obtained exploiting conventional ddm product hence new product used improve complement conventional remote sensing techniques sea ice observation
genetic mutations innate immune receptor nucleotide binding oligomerization domain containing nod demonstrated increased susceptibility crohn disease inflammatory bowel disease hypothesized accompanied changes gut microbiota nod responds presence bacteria specifically fragment bacterial cell wall muramyl dipeptide mdp proposed site interaction leucine rich repeat lrr domain surface plasmon resonance molecular modeling used investigate interaction lrr domain mdp functional pure lrr domain obtained escherichia coli expression high yield lrr domain binds mdp high affinity critical portions receptor determined mutagenesis putative binding residues fragment analysis mdp revealed peptide carbohydrate portion contribute binding interaction
background ovarian cancer early detection markers vary healthy women limiting utility screening methods evaluated cross sectional relationships lifestyle reproductive factors markers among controls nested case control study european prospective investigation cancer nutrition epic improvements discrimination prediction models adjusting correlates markers evaluated among postmenopausal women nested case control study cases generalized linear models used calculate geometric means limit detection evaluated using logistic regression early detection prediction modeled using conditional logistic regression results concentrations lower higher post premenopausal women among postmenopausal women higher among women higher parity older age menopause trend lower among women reporting oophorectomy hysterectomy ever use estrogen hormone therapy current smoking concentrations higher among heavier women former smokers higher older age blood collection current smokers inversely associated use duration parity older age menopause associations observed adjusting correlates markers prediction models improve discrimination conclusions study provides insights sources variation ovarian cancer early detection markers healthy women informs utility individualizing marker cutpoints based epidemiologic factors
article examines perceptions low income consumers receiving government assistance choices make showing group viewed differently resources even making identical choices series five experiments reveal ethical purchases polarize moral judgments whereas individuals receiving government assistance perceived less moral choosing ethical conventional products income earners particularly high income individuals perceived moral making identical choice price central component effect equating cost ethical conventional goods provides receiving government assistance protection harsh moral judgments choosing ethically moreover earning one income drives perceptions deservingness right spend one desires receive assistance via taxpayer dollars greater scrutiny frequently resulting harsher moral judgments others addition influencing perceptions individual consumers results demonstrate attributions extend groups make ethical choices others behalf attributions real monetary consequences nonprofit organizations
purpose paper construct validate underlying factorial structure attitude predictors measurement scale towards halal skin care product analysis based sample among user nonuser collected via drop collects survey technique quota sampling approach used data collection subsequently confirmatory factor analysis cfa executed confirm validate factorial structure results confirmed factor structure conceptualized spiritual intelligence spiritual congruence product image product involvement published elsevier open access article license http creativecommons org licenses
recent advances medical treatment emergency applications need integrating wireless body area network wban cloud computing motivated providing useful real time information patients health state doctors emergency staffs wban set body sensors carried patient collect transmit numerous health items medical clouds via wireless public communication channels therefore cloud assisted wban facilitates response case emergency save patients lives since patient data sensitive private important provide strong security protection patient medical data public insecure communication channels paper address challenge participant authentication mobile emergency medical care systems patients supervision propose secure cloud assisted architecture accessing monitoring health items collected wban ensuring high level security providing mutual authentication property chaotic maps based authentication key agreement mechanisms designed according concept diffie hellman key exchange depends cmbdlp cmbdhp problems security performance analyses show proposed system guaranteed patient privacy system confidentiality sensitive medical data preserving low computation property medical treatment remote medical monitoring
clear identification areas vulnerable waterborne diseases essential protecting community health particularly important developing countries unsafe disposal domestic wastewater limited potable water supply pose potential public health risks however data paucity compounding issue circumstances landscape epidemiology applied resource efficient approach mapping potential disease risk areas associated poor sanitation however order realise full potential offered approach depth understanding impact different classes explanatory variable target disease validity hotspot analysis using limited datasets needed accordingly research study focused typhoid diarrhoea incidence respect different classes elevation flood inundation land use soil permeability population density rainfall explanatory variables integrated methodology consisting hot spot analysis poisson regression employed map potential disease risk areas study findings confirmed significant differences influence exerted various classes explanatory variable relation target disease results also confirmed feasibility hotspot analysis identifying areas vulnerable target diseases using limited dataset study outcomes expected contribute creating depth understanding relationship disease prevalence associated landscape factors delineation disease risk zones context data paucity elsevier ltd rights reserved
angioedema urticaria often constitute challenge daily clinical practice may either occur present independent conditions characterized complex pathomechanism symptoms may triggered diverse factors differences crucial developing successful treatment regimen conditions may allergic origin immunoglobulin non ige related usually induced histamine nonallergic one bradykinin mediated angioedema patients inhibitor inh deficiency angioedema induced certain drugs angiotensin converting enzyme inhibitors currently distinguish types nonallergic angioedema hereditary angioedema hae due inh deficiency acquired angioedema aae angioedema induced renin angiotensin aldosterone system mediated bradykinin well pseudoallergic angioedema idiopathic angioedema bradykinin mediated angioedema laryngeal angioedema may life threatening resistance corticosteroids antihistamine drugs inh concentrates drugs choice treatment hae aae recent years new drugs introduced treatment bradykinin mediated angioedema bradykinin receptor antagonist icatibant kallikrein inhibitor ecallantide allow improve treatment outcomes
describe evolution introductory programming course active learning format thereby replacing traditional textbook online tutoring system integrative version find strong positive correlation student achievement scores integrated online textbook exercises quizzes well overall course achievement however observe comparable performance across learning assessment categories comparing subsequent course offerings particularly note slightly lower average performance programming assignments quizzes flipped classroom offering active learning format offering perceive performing students higher average score interactive textbook environment skipped fewer overall assignments lower performing learners additionally find students performing well online self guided hands programming exercises perform significantly better lower performing peers
hydraulic retarders auxiliary braking devices reduce velocity vehicle particularly vehicle driven downhill velocity reduction could reduce potential risk caused brake failure caused service brake working long time temperature brake shoe becomes extremely high paper introduces construction hydraulic retarder proposes two mathematical models hydraulic retarder first mathematical model deduced using fluid mechanics used analyze mechanism braking torque produced key factors influence value braking torque second mathematical model deduced using thermodynamics used quantify heat produced hydraulic retarder research emphasizes flow rate average velocity working fluid working chamber mainly determine braking torque hydraulic retarder flow rate working chamber determines temperature rise working fluid computational fluid dynamics cfd simulations conducted reynolds averaged navier stokes rans shear stress transport sst turbulent models experiments carried justify two mathematical models cfd simulations results show mathematical models capable describing force analysis energy conversion hydraulic retarder sst accurate cfd simulation error within
great deal attention manufacturing engineering focused finishing operations hard brittle materials recent years paper reports experimental work analysis surface roughness material removal using design experiment doe method magnetic abrasive finishing maf flat surfaces change surface roughness material removal found increase increase weight percentage abrasive particles magnetic abrasive brush lubricant volume decrease working gap also decrease relative size abrasive particles vis vis iron particles would result increase surface roughness decrease material removal observed work piece hardness considerable effect process results optimum parameter levels lead best surface finish highest material removal also derived experimentations optimum levels included weight percentage abrasive particles lubricant volume working gap relative size abrasive particles vis vis iron particles work piece hardness hbn disk type test pieces selected two side surfaces experiments experiments made using milling machine spindle magnetic pole holder table fixture holder work pieces
examine whether workplace climate quality staff relationships qsr manageable clinic workload mcw related better patient care experiences diabetes care community health centers chcs catering latino chinese patients patient experience surveys adult patients type diabetes workplace climate surveys clinicians staff chcs included analytic sample comparisons means analyses examine patient provider characteristics associations qsr mcw diabetes care management examined using regression analyses diabetes care process consistently provided chcs high quality staff relations manageable clinic workload hbac ldl cholesterol blood pressure outcomes different clinics high low qsr mcw focusing efforts improvements practice climate may lead consistent provision important processes diabetes care patients
background although understanding stratum corneum infant skin important avoid skin diseases atopic dermatitis investigation indonesian infants date objective obtain basic knowledge characteristics indonesian infants order develop methods infant specific skin care prevent dermatitis infection methods seventy two healthy full term infants aged months native indonesians residing jakarta enrolled study mothers also enrolled study adults transepidermal water loss tewl hydration capacitance thigh buttock upper arm measured sufficient acclimation air conditioned room infants mothers results hydration significantly higher infants adults sites measured including buttocks diaper area infant tewl values also significantly higher adults sites hydration tewl values showed significant correlation age infant site hydration tewl values indonesian infants decrease adult values within months indicates characteristics infants continue develop months age conclusion indonesian infants aged months significantly higher hydration tewl values indonesian mothers however infant age correlation hydration tewl values paediatr indones doi
background online social networks share similar topological characteristics real world social networks many studies conducted analyze online social networks difficult link human interests social network software design purpose goal work propose methodology involving analysis human interactions use designing online social network software methods propose novel use social network analysis techniques elicit requirements order design better online social network based software validation case study involved collection real world data means questionnaire perform network design construction analysis key idea examine social network help identification behaviors interests people better software requirements elicitation results validation case study demonstrates unexpected centrality measures emerge real world networks case study thus conducted baseline better requirement elicitation studies online social network software design work also indicates sociometric methods may used analyze social domain possible standard practice online social network software design overall study proved effectiveness proposed novel methodology design online social network software methodology specifically improves upon traditional methods software design involving social network modeling analysis first study behavior elicit requirements develop resilient online social network sites
background tumor necrosis factor alpha tnf alpha inhibitors revolutionized treatment many inflammatory diseases sinusitis initiation tnf inhibitors observed well described literature aim characterize clinical features sinusitis patients anti tnf alpha therapy methods retrospective chart reviewof patients tnf inhibitor diagnosed sinusitis otolaryngologists duke university patient demographics sinusitis characteristics treatment course studied chart review results prevalence sinusitis diagnosed treated otolaryngologist less patients studied history preexisting sinusitis new onset sinusitis diagnosed chronic rhinosinusitis without polyps crssnp disease mainly involving maxillary ethmoid sinuses patients hadmajor extrasinus complications required hospital admission intravenous antibiotics including new onset patients required surgical intervention initiating anti tnf therapy cohort improvement sinonasal symptoms stopping changing holding doses tnf alpha inhibitor conclusion anti tnf alpha therapy associated new onset sinusitis mainly crssnp overall percentage patients tnf inhibitor seeking consultation otolaryngologist low patients new onset sinusitis require surgery modification anti tnf therapy considered option medical management patients arsaaoa llc
nitrogen ions five different energies kev implanted crni steel base samples high vacuum temperature degrees base implanted samples also annealed degrees high vacuum similar bar energy dependent change structure mechanical properties implanted samples observed annealing process structural study suggested formation nitrides implantation induced surface segregation nitrogen nano indentation hardness elastic modulus increased gpa respectively increasing energy implantation process significantly enhanced cavitation erosion resistance base steel minimum cumulative weight loss maximum erosion resistance obtained sample implanted kev energy roughness values surfaces various erosion periods correlated erosion process understand erosion mechanism lowest roughness values cavitation erosion test obtained sample implanted kev energy
runoff water management among inherent challenges face sustainability development arid urban centers areas particularly risk flooding due rainfall concentration heavy showers hand susceptible drought capital sudan khartoum stands exemplary issues hence research study aims investigating potential applying rainwater harvesting rwh khartoum city center potential urban runoff management tool rapid urbanization coupled extension impervious surfaces intensified heat island khartoum consequently increased frequency heat waves dust storms dry summer streets flooding rainy season led environmental economical health problems study starts exposing rainfall behavior khartoum investigating rainfall variability number raindays distribution rain season probability daily rainfall maximum daily rainfall deficit surplus rain time daily rainfall data show strong falls occur almost every wet season decreased intra inter annual rainfall surpluses well increased rainfall concentration month august taking place year rainfall variability calculated decade interval since increasing variability revealed coefficients variation annual values wettest months july september aforementioned rainfall conditions paper explores potential rwh khartoum city center option storm water management since drainage system covers study area potential runoff center area computed using united states natural resources conservation services method nrcs weighted curve number found confirming dominant imperviousness rainfall threshold runoff generation found runoff generated rainfall probability one year return period equals drainage system capacity extreme rainfall produces runoff equivalent fourfold drainage capacity suggested former latter volumes mentioned could harvested applying rational method rooftops commercial business district area respectively based results six potential sites chosen rwh total roof catchment area potential rooftop rwh per unit area results reflect rwh potential effective urban runoff management better water resources utilization rwh would provide alternative source water tackle drought phenomenon elsevier rights reserved
purpose study examine associations among bone mineral density osteopenia osteoporosis body mass index bmi body composition patients heart failure total patients age years male underwent dual energy ray absorptiometry scans determine bone mineral density body composition multivariable linear regressions bmi relative skeletal muscle index rsmi mineral free lean mass positively associated total body bone mineral density mineral free lean mass strongly associated bone mineral density multivariable logistic regressions higher bmi rsmi mineral free lean mass associated lower odds osteopenia osteoporosis fat mass associated total body bone mineral density osteopenia osteoporosis results suggest muscle mass may important component body mass associated bone mineral density patients
occurrence different antagonists plant greatly affect infochemicals ecological consequences higher trophic levels investigated presence plant pathogen powdery mildew erysiphe cruciferarum brassica rapa affects plant volatiles emitted response damage specialist herbivore pieris brassicae attraction parasitic wasp cotesia glomerata performance brassicae glomerata plant volatiles significantly induced herbivory healthy mildew infected plants quantitatively lower mildew infected plants compared healthy plants parasitoids strongly preferred pieris infested plants dually infested pieris mildew plants preferred dually infested plants mildew infected plants performance brassicae unaffected powdery mildew glomerata cocoon mass reduced parasitized caterpillars developed mildew infected plants thus avoidance mildew infested plants may adaptive glomerata parasitoids whereas brassicae caterpillars may suffer less parasitism mildew infected plants nature pest management standpoint concurrent presence multiple plant antagonists affect efficiency specific natural enemies may turn negative impact regulation pest populations occurrence different antagonists plant multitrophic consequences community level show infection fungal pathogen powdery mildew erysiphe cruciferarum brassica rapa strongly reduces plant volatiles emitted response damage insect herbivore pieris brassicae reduces plant attractiveness main natural enemy brassicae parasitic wasp cotesia glomerata herbivore performance unaffected presence powdery mildew parasitoid performance negatively affected decreased cocoon mass pest management standpoint presence powdery mildew brassica plants may affect foraging efficiency natural enemies may turn negative impact regulation pest populations
millions men result natural aging process injury illness medical therapies experience decline testosterone levels necessitate need testosterone supplementation therapy tst signs symptoms testosterone decline may occur gradually low testosterone levels may misdiagnosed medical conditions past two decades increase testing testosterone levels use tst many men tst essential health care professionals know signs symptoms causes testosterone decline testosterone deficiency diagnosed pathological changes associated testosterone decline benefits risks tst addition health care providers need aware various forms testosterone available well advantages disadvantages article provides brief overview testosterone deficiency tst treatment options guidelines risks benefits associated tst
quetiapine low affinity dopamine receptor antagonist approved treatment bipolar disorder schizophrenia children adolescents food drug administration european medicine agency although knowledge adverse drug reactions children adolescents scarce quetiapine increasingly used youth denmark aim case study discuss adverse drug events ades spontaneously reported danish medicines agency quetiapine used pediatric population relation adversive drug reactions adrs reported european summary product characteristics spcs ade report database danish medicines agency searched quetiapine adrs involving individuals years period fifteen ade case reports retrieved scrutinized categorized average age years range years six patients boys main reported ades endocrine example hyperprolactinemia hyperthyroidism cardiac example tachycardia prolongation iii neurological example seizures cerebral hemorrhage psychiatric example hallucinations reported ades life threatening listed adrs spcs label use quetiapine children adolescents gives rise safety concerns copyright wolters kluwer health inc rights reserved
important advances afoot field neurosurgery particularly realms deep brain stimulation dbs deep brain manipulation dbm newly introduced refinement closed loop deep brain stimulation cldbs use closed loop technology make dbs dbm precise procedures broaden indications cldbs utilizes feedback variety sources electrophysiological neurochemical afferent information function brain structures treated studied efferent actions either electric classic excitatory inhibitory ones micro injection things neural proteins transmitters neural grafts implants pluripotent stem cells mesenchymal stem cells variants gene therapy pathologies treated beside parkinson disease movement disorders include repair neural tissues neurodegenerative pathologies psychiatric behavioral dysfunctions schizophrenia various guises bipolar disorders obesity anorexia drug addiction alcoholism possibility using new modalities treat number cognitive dysfunctions also consideration dbs cldbs technology brings cross fertilization scientific investigation surgical practice also contribute enhanced understanding brain function published elsevier inc
objective aim study evaluate efficacy multimodal neurophysiologic intraoperative monitoring iom cohort patients underwent posterior cervical surgery material methods total patients included study multi modal intraoperative monitoring miom somatosensory evoked potentials ssep transcranial motor evoked potentials tce mep spontaneous electromyography emg performed consecutive series patients patients control group classified patients high cervical operation group low cervical operation group based level surgery analyzed respectively results one hundred eleven cases showed true negative results fourteen patients cases operation cases operation met criteria neurophysiologic changes operation cases restored normal operation spontaneously cases surgical manipulation cases related operation unrestored neurophysiologic cases showed new post operative neurological deficits four patients showed neurological deficits without changes miom false negative cases delayed onset palsy case palsy conclusions proper application miom may useful detect intraoperative neurological injury posterior cervical operations improve surgical outcomes especially subgroup operation however efficacy miom may restricted detect prevent delayed onset palsy elsevier rights reserved
active electronically scanned array aesa beamforming method provides enhanced selectivity interference rejection number antennas compared conventional delay sum das beamforming proposed conventional das transfer function modified introducing complex pole manifolds based recently proposed infinite impulse response iir beam filters guaranteed stability continuous time domain signal flow graph proposed based first order pass filters eliminate need transmission line based delays used conventional das beamformers improved interference rejection verified using closed form signal processing models array antennas desired signal direction arrival doa interference doa array broadside proposed scheme shows improvement signal interference ratio sir around number antennas compared das beamforming improvement interference rejection observed uniform non uniform aperture weights terms side lobe performance feasibility study presented potential cmos circuit implementation proposed aesa linear array eight antennas maximum operational frequency ghz
fast three dimensional discrete cosine transform algorithm fct fast inverse cosine transform ifct algorithm presented suitable analysis data points many existing algorithms three dimensional data points make use either cosine transform cosine transforms existing algorithms based discrete cosine transform dct apply separable transform data points directions respectively based transforms apply cosine transform planes cosine transform direction proposed dct algorithms handle data points directly shown computationally efficient involve decomposition process data volume recursively decomposed dimension unit data cubes obtained algorithms presented form signal flow graph captures various computations involved complexity analysis along empirical results included demonstrating performance proposed direct dct algorithms fct ifct symmetric relatively fast used application requiring real time symmetric codec video conferencing online multiparty video games three dimensional graphics rendering
paper addresses problem joint inference optimization wireless networks optimization framework based information geometric network inference developed implemented using real radio emulation testbed scalable solutions infer end end rate distributions stochastic network flows link rate measurements proposed low complexity solutions apply underlying network inference network tomography problem decomposed smaller size subproblems solved independently partially inferring flow rates interest solutions extended infer flow rates jointly link loss rates retransmissions considered unreliable wireless links using inferred distributions flow rates inference mechanism presented optimize network performance first distributions flow rates inferred average rate measurements selected links distributions links rates computed inferred distributions flow rates finally inference results used network optimization weighted sum link outage probabilities minimized adapting power control routing decisions mobile wireless access approach iterated network inference optimization providing link outage end end throughput gains compared static approaches fixed network inference optimization parameters joint network inference optimization framework implemented real configurable radios performance verified hardware loop emulation test results obtained actual radio transmissions emulated channels
reproducibility experiments one main principles scientific method however numerical body experiments especially planetary systems currently reproducible themost optimistic scenario replicated approximate statistical sense even authors share full source code initial conditions differences compilers libraries operating systems hardware often lead qualitatively different results provide new set easy use open source tools address issues allowing exact bit bit reproducibility body experiments addition generating completely reproducible integrations show framework also offers novel innovative ways analyse simulations example present high accuracy integration solar system spanning gyr requiring several weeks run modern cpu framework easily access simulation data predefined intervals save snapshots time integration achieve integrating demand reconstructed simulation forward time nearest snapshot allows extract arbitrary quantities point saved simulation exactly bit bit within seconds rather weeks believe tools present paper offer new paradigm body simulations run analysed shared across community
sphingosine phosphate sip simple bioactive sphingolipid metabolite plays key role intracellularly extracellularly various cellular processes proliferation survival migration inflammation angiogenesis endothelial barrier integrity cellular level low tightly regulated synthesis degradation sphingosine kinases sphks catalyze atp dependent phosphorylation sphingosine degradation mediated reversible dephosphorylation catalyzed phos phatases lipid phosphate phosphatases irreversible degradation hexadecenal ethanolamine phosphate sphingosine phosphate lyase spl ligand specific protein coupled receptors differentially expressed different cell types generates downstream signals play crucial role developmental disease related pathologies addition acting extracellularly receptors located plasma membrane also act intracellularly independently affecting calcium homeostasis cell proliferation sphks spl metabolic pathway implicated numerous human pathologies including respiratory disorders thereby raising possibility manipulating intracellular levels could offer therapeutic potential ameliorating lung diseases review focuses prospects targeting signaling metabolizing enzymes using small molecule inhibitors receptor agonists antagonists treatment lung diseases elsevier inc rights reserved
atherosclerotic cardiovascular disease cvd leading cause mortality morbidity worldwide coronary artery disease cad single leading cause death better control risk factors enhanced diagnostic techniques improved medical therapies substantially decreased mortality cad developed countries however cad forms atherosclerotic cvd projected remain leading cause death face number challenges outcomes cad improved fact substantial fraction high risk subjects reach treatment goals important risk factors one challenges time also non negotiable fraction concealed high risk subjects detected current risk algorithms diagnostic modalities recent years started rapidly increase knowledge framework common genetics underlying cad atherosclerotic cvd population conjunction modern diagnostic therapeutic options new genetic knowledge may provide valuable tool improvements prevention review summarizes recent findings search common genetic risk factors cad furthermore author discusses recent findings could potentially used number clinical applications within cad prevention including clinical risk stratification prediction drug treatment response search targets novel preventive therapies
six phthalates dimethyl phthalate dmp diethyl phthalate dep isobutyl phthalate dibp butyl phthalate dnbp butyl benzyl phthalate bbzp ethylhexyl phthalate dehp indoor gas phase dust samples measured thirty residential apartments first time chongqing china monte carlo simulation used estimate preschool children exposure via inhalation non dietary ingestion dermal absorption based gas phase dust concentrations risk assessment evaluated comparing modeled exposure doses child specific benchmarks specified california proposition detection frequency targeted phthalates except bbzp dmp predominant compound gas phase median living rooms bedrooms respectively dehp predominant compound dust samples median living rooms bedrooms respectively correlation analysis suggests indoor dibp dnbp might come emission sources simulations showed median dehp daily intake day age groups suggesting greatest targeted phthalates risk assessment indicated exposure doses dnbp dehp exceeded child specific benchmarks preschool children chongqing therefore children health perspective efforts focus controlling indoor phthalate concentrations exposures elsevier ltd rights reserved
electric machines concentrated winding single tooth design provide cost effective way use flat wires hereby high filling factors achieved due geometric constraints influence current displacements remains unused space inside slot space used water cooling channels result small thermal resistance winding cooling fluid leads outstanding cooling performance compared round wires efficiency improved wide parts operating area absence cooling jacket leads comparable production costs even compact machine design technological aspects discussed particular high power density interior permanent magnet synchronous machine ipmsm water jacket cooling round wires compared flat wire wound slot cooled motor use fem cfd simulations measurements single tooth specimen
prosocial behavior considered important dimension positive development although previous research suggests quality children early relationships may influence prosocial behaviors specific contributions mother father teacher children prosocial behavior less examined cross sectional study investigates combined associations mother father teacher child relationships prosocial behavior children aged months mediating role teacher child relationship association parent child relationship prosocial behavior results suggested positive link quality relationships early caregivers children prosocial behavior quality father teacher child relationships found direct association children prosocial behavior quality mother child relationship indirectly linked children prosocial behavior via teacher child relationship results suggesting connections multiple relational contexts discussed based notion internal working models proposed attachment theory mothers fathers contributions children prosocial behavior also discussed considering differences relational styles changing roles mothers fathers dual earner families
men women violate traditional expectations regard professional status perceived negatively others face negative outcomes workplace examine whether negative perceptions extend observers evaluations status violators intimate relationships employed fictional scenario depicting heterosexual married couple manipulating professional status character holding information constant participants projected lower relationship satisfaction onto husband lower professional status wife nontraditional condition participants condition also liked sympathized wife less perceived power relationship husband finally effects mediated ratings characters perceived normative masculinity femininity findings contribute existing research penalties male female gender role violators face suggesting additional consequences outsiders perceptions intimate relationships
purpose purpose paper present four level architecture aims integrating publishing retrieving ecological data making use linked data allows scientists explore taxonomical spatial temporal ecological information access trophic chain relations species complement information data sets published web data development ecological information repositories crucial step organize catalog natural reserves however present challenges regarding effectiveness provide shared global view biodiversity data data heterogeneity lack metadata standardization data interoperability rose interesting technology solve challenges design methodology approach ecological data produced collected different media resources stored distinct relational databases published rdf triples using relational resource description format mapping language application ontology reflects global view datasets share vocabulary scientists specify data views selecting objects interest friendly way adata view internally represented algebraic scientific workflow applies data transformation operations integrate data sources findings despite years investment data integration continues offering scientists challenges obtaining consolidated data views large number heterogeneous scientific data sources semantic integration approach presented paper simplifies process terms mappings query answering data views social implications work provides knowledge guanabara bay ecosystem well source answers anthropic climatic impacts bay ecosystem additionally work enable evaluating adequacy actions taken clean guanabara bay regarding marine ecology originality value mapping complexity traded process generating exported ontology approach reduces problem integration mappings homogeneous ontologies byproduct data views easily rewritten queries data sources architecture general although applied ecological context extended domains
dietary source foliage eucalyptus spp low available protein carbohydrate containing polyphenolic compounds interfere enzymatic digestion overcome koala phascolarctos cinereus evolved range anatomical physiological adaptations assist digestion absorption nutrients food source microbial fermentation partially digested eucalyptus leaves thought critical process however little known composition diversity microorganisms associated digestive health native species study performed rrna gene pyrosequencing caecum colon faecal pellet samples two wild free ranging queensland koalas results reveal highly complex diverse ecosystem considerable intra individual variation although samples dominated sequences bacteroidetes firmicutes phyla considerable variation genus level study first non culture based microbiota analysis using amplicon pyrosequencing provides preliminary data expand understanding koala hindgut elsevier rights reserved
background nonadherence treatment prevalent issue internet interventions guidance health care professionals found increase treatment adherence rates internet interventions range physical mental disorders evaluating different guidance formats varying intensity important particularly respect improvement effectiveness cost effectiveness identifying predictors nonadherence allows opportunity better adapt internet interventions needs participants especially risk discontinuing treatment objective goal study investigate influence different guidance formats content focused guidance adherence focused guidance administrative guidance adherence identify predictors nonadherence internet based mobile supported stress management intervention get stress employees methods data groups received intervention pooled three randomized controlled trials rcts evaluated efficacy internet based mobile supported stress management intervention rcts differed terms guidance format content focused guidance waitlist control adherence focused guidance waitlist control administrative guidance waitlist control adherence defined number completed treatment modules anova performed compare adherence rates different guidance formats multiple hierarchical linear regression analysis conducted evaluate predictors nonadherence included gender age education symptom related factors hope improvement results content focused guidance sample adherence focused guidance sample participants administrative guidance sample completed treatment modules guidance significant effect treatment adherence omega participants content focused guidance mean adherence focused guidance samples mean completed significantly modules participants administrative guidance sample mean content focused guidance significantly associated higher adherence compared adherence focused guidance effect size pass equivalence margin upper bound lay predefined margin indicating equivalence adherence focused guidance content focused guidance beyond influence guidance none predictors significantly predicted nonadherence conclusions guidance shown influential factor promoting adherence internet based mobile supported stress management intervention adherence focused guidance included email reminders feedback demand equivalent content focused guidance regular feedback requiring approximately quarter coaching resources could promising discovery terms cost effectiveness however even considering guidance sociodemographic symptom related characteristics interindividual differences nonadherence remain unexplained
allergic conjunctivitis inflammatory disease conjunctiva characterized antigen challenge toll like receptor tlr activation designed small peptide found contain therapeutic potential staphylococcal enterotoxin seb induced model treatment showed remission clinical signs plasma total ige levels number mast cells proportion degranulated mast cell mice levels cytokines lymph nodes spleen significantly decreased cytokine ifn gamma increased treated group suggesting protective role mediating balance cytokines importantly significantly inhibited tlr expression conjunctival tissue combined therapeutic effects tlr inhibitory function might ideal candidate development new therapeutic agent allergic disease published elsevier
recently bearingless switched reluctance motor blsrm received attention realize stable levitation rotation corresponding suspending force torque controlled paper different conventional bearingless srm control one independent control scheme levitation force torque presented control complex control algorithm based lookup table needed torque control separated radial force control channel radial force independently controlled therefore control simple implemented first based brief introduction blsrm structure operating principle mathematical relationship levitation force respect current displacement derived furthermore rotor dynamics model levitation force four degrees freedom considered established based given analysis digital control system includes torque suspending force designed means tmsf experimental platform established according experimental results proposed blsrm steadily levitated static rotating conditions
electromagnetic methods commonly employed detect wire rope discontinuities however determining residual strength wire rope based quantitative recognition discontinuities remains problematic designed prototype device based residual magnetic field rmf ferromagnetic materials overcomes disadvantages associated service inspections large volume inconvenient operation low precision poor portability providing relatively small lightweight device improved detection precision novel filtering system consisting hilbert huang transform compressed sensing wavelet filtering presented digital image processing applied achieve localization segmentation defect rmf images statistical texture invariant moment characteristics defect images extracted input radial basis function neural network experimental results show rmf device detect defects various types wire rope prolong service life test equipment reducing friction detection device wire rope accommodating high lift distance
recently several innovative suggestions industrial wastes utilised new products presented literature filler additives concrete incorporated ceramic materials produce glass ceramics pavement construction work metallurgical materials secondary aluminium scrap processing glass waste derived treatments packaging fluorescent lamps considered fabrication new ceramic materials using powder technology sintering process effect composition heat treatment temperature sintering process final properties evaluated results showed proper firing temperature lightweight ceramic materials containing high amount glass waste innovative product resulting processing secondary aluminum argalum produced low water absorption low density good flexural strength mpa associated relatively low sintering temperatures obtained addition argalum considered promising initial results obtain new green building materials
proclaimed century biology rapidly leading realization starkly different complex biological materials materials underpinned industrial technological revolution differences arise part biological matter exhibits viscous elastic behavior moreover behavior varies across frequency wavelength amplitude spectrum forcing broadclass responsesin biological matter requires multiple frequency dependent functions specify material behavior instead discrete set parameters relate either viscosity elasticity complexity prevails even biological matter assumed spatially homogeneous rarely true however little progress made characterization heterogeneity build information constitutive laws predictive models addition biological matter non stationary motivates term living biomaterials typically active state order perform certain functions often modified replenished basis external stimuli become popular materials engineering try duplicate functionality biomaterials lot effort gone design self assembling self healing shape shifting materials distinguishing features biomaterials require significantly degrees freedom traditional composites many molecular species roles functionality yet determined typical biological material includes small molecule biochemical species react diffuse within larger species large molecular weightspecies provide primary structural biophysical properties material small molecule binding unbinding kinetics serves modulate material properties typical small molecule production release governed external stimuli stress bottom line mathematical numerical tools century materials science often insufficient describing biological materials predicting behavior vitro vivo
communication major impact customers perceive sellers organizations especially non verbal communication body language appearance facial expressions gestures proximity posture eye contact influence positively negatively first impression customers experiences stores salespeople many countries especially developing ones telling companies products unaware real role sellers importance non verbal communication saudi arabia seller profession exclusively foreign labor recently saudi workforce enters retailing sector sellers non verbal communication sellers never evaluated consumer point view therefore aim paper explore non verbal communication barriers customers facing dealing saudi sellers discussing nonverbal communication skills sellers must light previous academic research depth interviews seven focus groups saudi customers study found saudi customers totally satisfied current non verbal communication skills saudi sellers therefore strongly recommended develop non verbal communication skills saudi sellers intensive trainings distinguish appearance sellers especially female ones focus time intervention well proximity customers aimi journals
prove identifiability tree parameters class jukes cantor mixture model proof uses ideas algebraic statistics particular finding phylogenetic invariants separate varieties associated different triples trees computing dimensions resulting phylogenetic varieties using disentangling number reduce trees small number leaves symbolic computation also plays key role handling many different cases finding relevant phylogenetic invariants elsevier inc rights reserved
purpose immigration customs enforcement ice takes place community near school property maintaining school environment conducive learning difficult article examines school leader personnel perceived impact ice activity community students families whether school personnel incorporated community concerns response exhibited ethic community research methods approach data come embedded case study educators school experienced ice activity close school grounds findings principal school personnel tried minimize impact uncertainty ice presence neighborhood could school environment took steps limit short term long term effects community personnel demonstrated prioritizing relationships dialogue collaboration undocumented community members central decision making process implications research practice school leaders practitioners may know legal ethical responsibilities toward undocumented students anticipate contexts related legal status students family members article highlights need schools school districts create policies resources protect undocumented students educational rights ensure personnel receive training policies research expand understanding personnel respond sensitive personal legal contexts involving undocumented families
quality highway roadbed construction affects overall performance highway important highway construction roadbed crucial part highway engineering stability directly restricts process highway roadbed construction quality engineering costs relates security people lives property regional economic development roadbed soft foundation treatment key construction subgrade usually apply pad chemical fiber non woven fabrics geotextile glass fiber grating way deal soft foundation article analyze monitoring data highway roadbed engineering study process means highway roadbed monitoring actually helps guides deal highway soft foundation significantly
report case sudden unexpected death young woman found bathtub hot water autopsy concluded possible causes sudden loss consciousness except cardiac origin could excluded however heart show obvious pathological changes used next generation dna sequencing ngs examine genes detected rare potentially pathogenic variants minor allele frequencies pathogenicity variants evaluated using silico predictive algorithms scna glyser cacnb serleu myh lysglu detected possible pathogenic variants inherited heart disease likely cause sudden unexpected deaths young people hot baths even clinical manifestation disease future molecular analysis ngs may help predict young early middle aged people could risk sudden arrhythmogenic fatality hot baths
introduction oil spill exposures associated increased levels depression often measured using continuous scores dichotomous cut points screening tools population based studies latent profile analysis overcome analytic limitations masking heterogeneity outcomes among people within dichotomous categories loss information symptom patterns among continuous score study examined variation depressive symptoms assessed associations depressive symptomatology oil spill exposure socioeconomic risk factors social capital methods interviewed women southeastern louisiana performed latent profile analysis tested adjusted associations sociodemographic characteristics oil spill exposure latent class membership results results indicated three class solution classes varied symptom severity best fit strongest associations among women severe depressive symptoms less educated economically vulnerable least social support compared women depressive symptoms limitations study limited cross sectional design self reported nature exposures depressive symptoms results consistent prior literature conclusions results support conventional use screening tools estimate depressive symptomatology nevertheless identification subgroups within study participants highlights important finding subgroups comprised characteristically different women varying levels depressive symptoms discovery would overlooked ces used conventionally elsevier rights reserved
earlier results indicated average household self sufficiency water supply achieved following urban harvest approach uha combination demand minimization cascading multi sourcing achieve results assumed available local resources harvested reality however temporal spatial location bound factors pose limitations harvest thus self sufficiency article investigates potential spatial temporal limitations harvest local water resources building level netherlands focus indoor demand two building types studied free standing house one four people household mid rise apartment flat two person households able model yearly water balances daily patterns considering household occupancy presence water using appliances defined per building type three strategies defined strategies include demand minimization light grey water lgw recycling rainwater harvesting multi sourcing recycling multi sourcing cater toilet flushing laundry machine results showed water saving devices may reduce conventional demand recycling lgw supply second quality water represents conventional demand minimized demand rainwater harvesting may supply approximately minimized demand case apartment flat case free standing house harvest potentials different system specifications related household type required two constraints recycle multi source identified namely limitations grey water production available rainfall potential harvest water determined temporal pattern water availability water use storage treatment capacities elsevier ltd rights reserved
background despite biochemical euthyroidism levothyroxine treated hypothyroid patients report persisting symptoms patients tentatively treated combination liothyronine combination therapy appropriate choice blood tests monitor treatment highly debated among specialists patients aim evaluate whether measuring serum triiodothyronine baseline combination therapy used indicator positive effect combination therapy materials methods observational retrospective study patients persisting symptoms hypothyroidism despite therapy normal tsh levels comorbidities could explain symptoms treated combination therapy dose ratio according european thyroid association guidelines based patient reported outcome divided responders nonresponders results five patients lost follow thus excluded month follow classified nonresponders responders months figures changed respectively comparing responders versus nonresponders differences seen baseline follow free estimates logistic regression showed correlation free estimates responder nonresponder status conclusion data indicate serum measurements suitable predict patient benefit combination therapy treatment response followed repeated measurements either european thyroid association published karger basel
major apple allergen mal predominant cause apple malus domestica allergies large parts europe northern america allergic reactions kda protein consequence initial sensitization structurally homologous major allergen birch pollen bet consumption apples subsequently provoke immunologic cross reactivity bet specific antibodies mal trigger severe oral allergic syndroms affecting individuals sensitized birch pollen accumulated immunological data suggest mal three dimensional fold similar bet experimental structural data protein available date first step towards structural characterization mal backbone side chain chemical shifts isoform mal assigned nmr chemical shift data show protein composed seven beta strands three alpha helices accordance reported secondary structure major birch pollen allergen indicating mal bet indeed similar three dimensional folds next stage characterization mal utilize resonance assignments solving solution structure protein
one biggest challenges health data sharing regulations prohibit transmission distribution personal health information phi even among collaborating organizations impedes research reduces utility datasets anonymization address issue hiding phi maintaining analytical utility data much research focused data static independent complete unfortunately typical health data instead static independent tables health data relational databases multiple high dimensional tables transactional constantly changing data recipients usually receive multiple versions database time study reviews literature anonymization methodologies large fast changing high dimensional datasets especially health data relevant papers analyzed categorized compared terms scope contributions finally used extracted details analysis outline possible research direction developing realistic anonymization framework health data sharing authors published elsevier
background although health disparities documented medicare beneficiaries based age years older age groups underuse recommended medical care younger beneficiaries thoroughly investigated study aim identify characterize vulnerabilities younger medicare age group aged years explore age group determinant use recommended care among medicare beneficiaries methods conducted cohort study community dwelling medicare beneficiaries participated medicare current beneficiary survey age group characteristics compared using cross sectional data baseline follow assessed association age receipt recommended care recommended care indicators adjusting sociodemographic clinical characteristics follow periods differed component indicator results baseline higher proportion younger beneficiaries experienced social disadvantage disability certain morbidities older age groups follow younger beneficiaries significantly less likely receive overall recommended care compared years age adjusted odds ratio confidence interval addition male gender non hispanic black race less high school education living alone children others psychiatric disorders higher activity limitation stages associated underuse recommended care conclusions younger medicare beneficiary status appears independent risk factor underuse appropriate care support ameliorate disparities different social health aspects may warranted
optimization product line architecture pla design modeled multi objective problem influenced many factors feature modularization extensibility design principles due properly solved search based software engineering sbse field however previous empirical studies optimized pla design using multi objective evolutionary algorithm nsga without applying one important genetic operators crossover overcome limitation paper presents feature driven crossover operator aims improving feature modularization pla design proposed operator applied two empirical studies using nsga comparison another version nsga uses mutation operators results show usefulness applicability proposed operator nsga version applies feature driven crossover found greater diversity solutions potential pla designs higher feature based cohesion less feature scattering tangling elsevier inc rights reserved
empirical studies software reliability predominantly focused end user applications given intrinsic dependency user programs operating system software failures severely impact even reliable applications therefore major requirement understand failures occur order improve software reliability whole paper present exploratory study failure causes based real failure records collected different computers running mass market operating system performed quantitative qualitative analyses investigate different properties failures analyzed findings indicate services failed failure category empirical evidences confirmed presence failure correlation sample cross correlation autocorrelation found particular causal relationship different operating system failures observed
people often discuss events seen discussions influence later recollections investigated effects factual emotional free retelling discussion memory recollections individuals witnessed event participants shown video made initial individual recall participated one three retelling conditions emotional versus factual versus free control condition recalled event individually participants factual free retelling conditions reported items previously recalled participants control condition emotional condition show advantage participants three retelling conditions failed report previously recalled items compared control condition finally memory conformity effect observed three retelling conditions findings suggest eyewitnesses discussions may influence accuracy subsequent memory reports especially discussions focused emotional details thoughts
study radiation exergy important significance solar energy high temperature engineering paper several exergy expressions blackbody radiation discussed differences petela expression exergy two expressions analyzed considering radiant energy thermal energy different radiation machine model established furthermore validity petela formula indicated model based concept radiation equivalent temperature integral form expression monochromatic photon exergy put forward establishing infinite staged carnot heat engine model time approximate relation equivalent temperature radiation wavelength given error relation negligible calculating exergy blackbody radiation within temperature range engineering field finally monochromatic photon entropy discussed considering infinite staged carnot heat engine model expression photon entropy integral form given monochromatic photon entropy exergy proposed paper satisfy thermodynamic relation reflect differences radiant energy thermal energy
present study tested whether mri relaxation time sensitive marker detect early stages amyloidosis gliosis young xfad transgenic mouse well established animal model alzheimer disease xfad wild type mice imaged varian horizontal bore mri system generate quantitative maps using spin echo multi slice sequence following immunostaining glial fibrillary acidic protein iba amyloid beta area fraction staining quantified posterior parietal primary somatosensory cortex corpus callosum comparison age matched wild type mice observed first signs amyloidosis month old xfad mice development gliosis month old xfad mice contrast mri relaxation times young month old xfad mice significantly different age matched wild type controls furthermore although disease progression detectable increased amyloid beta load brain month old xfad mice compared month old xfad mice mri relaxation time change summary data suggest mri relaxation time neither sensitive measure disease onset progression early stages xfad mouse transgenic mouse model
paper consider relaxed synchronous asynchronous multisplitting iteration schemes solving mixed linear complementarity problems matrix matrix establish convergence theorems methods numerical results show new methods efficient suitable parallel computing
permanent supportive housing psh evidence based health intervention persons experiencing homelessness impact individual mechanisms within intervention health requires research study examines longitudinal impact mechanism supportive housing within peer delivered psh model overall health mental health measured psychological distress self report bothersome symptoms outcomes ethnically diverse population participants study included persons homeless risk homelessness also diagnosed serious mental illness sixty one percent participants received supportive housing outcomes significantly associated quality life indicators recovery social connectedness addition overall health significantly associated employment age psychological distress psychological distress associated gender type housing history violence trauma experiencing bothersome symptoms associated drug use history violence trauma psychological distress longitudinal models outcomes showed supportive housing significantly associated good excellent health months baseline odds ratio confidence interval models also demonstrated supportive housing comparison groups experienced decreased psychological distress baseline results study demonstrate importance supportive housing within context psh particularly overall health participants positive overall impact psh mental health diverse population
paper proposes novel distance estimation method build forward collision avoidance assist system fcaas containing techniques lane marking detection vehicle tracking distance estimation first lane marking detection technique uses ransac algorithm extract lines lane markings previously collected inverse perspective mapping image filtered steerable filters kalman filter tracks extracted lines accurately efficiently second vehicle tracking technique implements multiple vehicle tracking method using particle filter tracks vehicles detected adaboost classifier improved particle filter implemented predict next movement vehicle spread particles near predicted location vehicle instead originally spreading particles around current location vehicle finally innovative distance estimation method derived estimate distance ego vehicle front vehicle distance estimation method verified setting several standard points image whose locations measured according regulation lane markings result verification distance estimation method demonstrates robust feasibility reality fcaas shows potential particular scenes many experimental sequences acquired highways real world addition fcaas fits demand real time speed system speed frames
aims aim study investigate antioxidant effects carnitine oxidative stress parameters oophorectomized rats methods twenty four female albino wistar rats used rats divided four groups laparotomy losaline group oophorectomy plus carnitine day oxl group oophorectomy plus carnitine day oxl group oophorectomy oxsaline group experimental protocol started day post castration various dosage forms carnitine isotonic saline administered intraperitoneally consecutive days nitric oxide malondialdehyde mda total antioxidant status tas total oxidative stress tos oxidative stress index osi evaluated tissues including kidney liver heart sera result heart tissue samples difference levels osi tos groups however mda levels oxsaline group significantly higher oxl group hand statistically significant differences groups terms levels mda tas tos osi liver kidney sera samples conclusion levels mda heart tissue significantly higher oxsaline group compared oxl group thus may suggested carnitine reduces oxidative stress least heart oophorectomized rats alexandria university faculty medicine production hosting elsevier open access article license http creativecommons org licenses
high dimensional data space generated hyperspectral sensors introduces challenges conventional data analysis techniques popular dimensionality reduction techniques usually assume gaussian distribution may accordance real life metric learning methods explore global data structure labeled training samples proved efficient hyperspectral fields however utilizing locally adaptive decision constraints labeled training samples per class obtain even better performance paper present locally adaptive dimensionality reduction metric learning ladrml method hyperspectral image classification aims presented method first utilize limited training samples reduce dimensionality data without certain distribution hypothesis second better handle data complex distributions use locally adaptive decision constraints assess similarity pair samples based distance changes metric learning experimental results obtained number challenging hyperspectral image datasets demonstrate proposed ladrml algorithm outperforms state art dimensionality reduction metric learning methods
health risk concerns associated household use rooftop harvested rainwater hrw constitute one main impediments exploit benefits rainwater harvesting united states however benchmark based epa acceptable annual infection risk level case per persons per year pppy developed aid drinking water regulations may unnecessarily stringent sustainable water practice study challenge current risk benchmark quantifying potential microbial risk associated consumption hrw irrigated home produce comparing current risk benchmark microbial pathogen data hrw exposure rates reported literature applied assess potential microbial risk posed household consumers homegrown produce quantitative microbial risk assessment qmra model based worst case scenario overhead irrigation pathogen inactivation applied three crops popular among home gardeners lettuce cucumbers tomatoes commonly consumed raw infection risks household consumers attributed consumption home produce vary type produce lettuce presents highest risk followed tomato cucumber respectively results show percentile values infection risk per intake event home produce one three orders magnitude lower epa risk benchmark pppy however annual infection risks scenario multiple intake events year likely exceed risk benchmark one order magnitude cases estimated percentile values annual risk pppy range still lower pppy risk range reclaimed water irrigated produce estimated comparable studies discuss desirability hrw irrigating home produce based relative risk hrw reclaimed wastewater irrigation food crops appropriateness pppy risk benchmark assessing safety level hrw irrigated fresh produce questioned considering assumptions made qmra model consequently need updated approach assess appropriateness sustainable water practice making guidelines policies proposed elsevier ltd rights reserved
improved continuum model three span suspension bridges developed study effects hanger extensibility free vertical vibrations model applied hinged continuous girders obtain equations motion coupled differential equations describing vertical deflections main cable girder derived dimensionless parameters following galerkin method shape functions main cable hinged continuous girders equations motion obtained matrix form compatibility equation used eliminate additional horizontal force main cable equations natural frequencies hinged continuous suspension bridges evaluated function six dimensionless parameters relative elastic bending stiffness girder relative elastic axial stiffness main cable relative elastic axial stiffness hangers relative mass girder relative length side span ratio main span sag maximum hanger length parametric studies conducted parameters varied individually observe effect natural frequencies identify differences conventional model inextensible hangers improved model extensible hangers found hanger extensibility affects natural frequencies mode shapes higher modes suspension bridges large relative girder stiffness effect slightly pronounced antisymmetric modes continuous bridges addition even bridge large relative girder stiffness hanger extensibility rarely affects natural frequencies higher modes bridge either large relative mass girder large relative length side span american society civil engineers
although patients may raise new concerns time medical visit closing phase consultation critical locus negotiation topicalization additional concerns using conversation analysis primary method analysis study provides analysis structure consultation closings korean primary care encounters way organization closings context discourages patients presentation additional concerns data drawn videotaped primary care encounters collected korea rare occasions last minute concerns raised closely analyzed reveal organization gaze body orientation play important role foreclosing presentation additional concerns results contribute understanding closings primary care interview investigating non western setting includes investigation understudied subject embodied resources shows closings serve doctor purpose bringing closure face last minute concerns broached patient cultural meaning gaze korean medical care context also discussed findings implications research nonverbal communication cultural differences interactions medical care elsevier ltd rights reserved
context traceability software product lines spl ability interrelate software engineering artifacts required links answer specific questions related families products underlying development processes despite existence studies map available evidence traceability single systems development lack understanding common strategies activities artifacts research gaps spl traceability objective paper analyzes studies dating discusses seven aspects spl traceability main goals strategies application domains research intensity research challenges rigor industrial relevance addition analysis paper also synthesizes available evidence identifies open issues points areas calling research method gather evidence defined mapping study process adapted existing guidelines driven set research questions process comprises three major phases planning conducting documenting review results work provides structured understanding spl traceability indicating areas research lack evidence regarding application research methods indicates need rigorous spl traceability studies better description context study design limitations practitioners although identified studies low industrial relevance high relevance thus could provide decision making support application spl traceability practice conclusions work concludes spl traceability maturing pinpoints areas investigation performed future work intend improve comparison traceability proposals spl single system development elsevier rights reserved
yield forecasting corn constitutes key issue agricultural management particularly context demographic pressure climate change study presents two methods estimate yields using artificial neural networks diagnostic approach based satellite data acquired throughout agricultural season real time approach estimates updated image acquired microwave optical domains formosat spot terrasar radarsat throughout crop cycle results based multispectral crop monitoring experimental campaign conducted cesbio centre etudes biosphere laboratory agricultural region southwestern france among tested sensor configurations multi frequency multi polarization multi source data best yield estimation performance using diagnostic approach obtained reflectance acquired red wavelength region coefficient determination rmse real time approach combination red reflectance backscattering coefficients provides best compromise accuracy earliness yield estimate months harvest rmse development central stem two best yield estimates similar cases monitored fields differences related discrepancies crop growth cycle consequences pests elsevier rights reserved
instant messenger often shortened one type communication service allows person conversation chat privately others via internet within calls messaging android ios operating systems equal value terms innovation performance work focus evaluate performance application android ios operating systems used several criteria delay packet size throughput usetwo methods data collection primary secondary data compare application using simulation methods input parameters simulation thestanza form text message output consists delay packet size throughput results work indicate ios operating system criteria delay packet size throughput send receive messages faster android operating system
objective objective study retrospectively determine prevalence image findings extraarticular talocalcaneal coalition sustentaculum type talocalcaneal coalition appear current classification systems patients imaging diagnosis foot coalition materials methods study performed using database query radiology reports ankle foot mri examinations performed august november eighty one patients identified keyword search database talocalcaneal coalition tarsal coalition coalition sustentaculum imaging features mri findings evaluated chart review used identify demographic information results extraarticular talocalcaneal coalition sustentaculum diagnosed patients nine men four women represents prevalence foot coalitions talocalcaneal coalitions four patients underwent surgical resection histology obtained three patients nine patients history trauma symptomatic patients bone marrow edema coalition sites mri also symptomatic coexisting extraarticular talocalcaneal coalition sustentaculum intraarticular talocalcaneal coalition observed patients conclusion sustentaculum component extraarticular talocalcaneal coalitions usually related presence symptoms patient sustentaculum symptoms medial talocalcaneal joint area extraarticular talocalcaneal coalition related sustentaculum considered
living walls innovative urban greening systems represent promising tool sustainable construction bioclimatic design use growing media support plant establishment growth vertical plane drip irrigation system mandatory installed supply water nutrients plants number installed urban areas rapidly growing important conduct studies optimize irrigation water use work therefore two main objectives optimizing irrigation scheduling non recirculating outdoor installed near seville spain assessing daily water needs summer period experimental setup consisted two multilayer modules plant density plants module consisted two geotextile layers sewn together forming pockets waterproof layer facing wall system attached wall means metal profile drip irrigation system consisted drip line placed upper part drippers spaced water losses drainage runoff collected semi circular gutter placed bottom module water applied water lost drainage recorded irrigation event volumetric water meter rain gauge respectively main microclimatic variables solar radiation air temperature relative humidity also recorded runoff hydrographs obtained three different emitter discharge rates well estimated water requirements presented discussed results indicate lost solution systems pulse drip irrigation suitable applying irrigation times maximize water distribution living wall evapotranspiration highly correlated reference evaportranspiration allowed derive mean garden coefficient
recent years many unexpected events earthquake tsunami world uncertainty damage emergency time quantity material demand disaster areas random time quantity send supplies also random order solve problem random emergency demand using method system simulation provides reasonable solution problem random demand period time statistics daily material consumption disaster area deducing mathematical laws generally obeyed ultimately calculate best amount transmission per day combined example daily distribution earthquake relief using computer programming simulation getting best daily amount transmission
paper presents study efficient implementation software changes helps students better understanding programming techniques algorithms study performed last three years first year students considering applications classes two first year courses computer programming part part taken account partial results semester final exams also questionnaires accomplished students ratings study imported database study regarding around eight hundred students
production azo derivatives amino analogue troger base hunlich base employing standard procedures diazotization azo coupling williamson etherification described versatile molecules possess shaped core photoswitchable groups carry two modifiable extremities enable synthesis molecular assembly synthesis straightforward requires inexpensive starting materials facilitates application different fields research light driven molecular machine design
patients irritable bowel syndrome ibs show poor response treatment however risk factors associated poor therapeutic response determined multicenter trial evaluated consecutive outpatients ibs undergoing treatment month mental health status physical function evaluated using japanese version therapeutic response evaluated using ibs severity index japanese version ibs sij patients ibs sij scores defined poor responders treatment whereas ibs sij scores defined good responders demographic clinical characteristics two groups along medications compared study enrolled participants ibs sij scores ibs sij scores multiple logistic regression analysis showed female sex odds ratio confidence interval mental component summary mcs independent risk factors poor therapeutic response patients ibs lower mcs female sex risk factors poor therapeutic response patients ibs ascertaining mechanisms lower mcs female sex associated poor therapeutic response ibs may help design better treatments trial registration number umin
traffic aware planner tap developed nasa langley research center support traffic aware strategic aircrew requests tasar project flight efficiency software application developed electronic flight bag efb tested two flight trials planned operational testing two commercial airlines tap real time trajectory optimization application leverages connectivity onboard avionics broadband internet sources compute recommend route modifications flight crews improve fuel time performance application utilizes wide range data including automatic dependent surveillance broadcast ads traffic flight management system fms guidance intent board sensors published winds weather special use airspace sua schedules paper discusses challenges developing deploying tap various efb platforms solutions challenges lessons learned assist commercial software developers hardware manufacturers efforts implement extend tap functionality environments efb applications tap typically access avionics data via arinc simple text avionics protocol stap server hosted aircraft interface device aid installed hardware protocol standardized data sources content transmission rates vary aircraft aircraft additionally method communicating aid may vary depending efb hardware availability onboard networking services ethernet wifi bluetooth mechanisms efbs portable installed components implemented using variety operating systems cockpits increasingly incorporating tablet based technologies expanding number platforms application may need support supporting multiple efb platforms aids avionics datasets user interfaces presents challenge software developers management code baselines maintaining multiple baselines support deployment targets extremely cumbersome expensive certification also needs considered developing application regardless whether software destined certified data requirements support application user interface elements may introduce certification requirements efb manufacturers airlines example tap challenges faced solutions implemented lessons learned give efb application hardware developers insight future potential requirements deploying tap similar flight deck efb applications
explicit instructions regarding stimulus threat associations increase acquisition extinction fear healthy participants current study aimed investigate effect contingency instructions fear acquisition extinction patients anxiety disorders patients various anxiety disorders healthy comparison participants participated differential fear conditioning task within subjects design approximately halfway acquisition phase participants instructed stimulus threat association approximately halfway extinction phase participants informed unconditioned stimulus would longer administered outcome measures fear potentiated startle skin conductance fearfulness ratings expectancy ratings patients demonstrated overall increased physiological subjective fear responses acquisition extinction phases relative comparison group major differences fear acquisition extinction patients different anxiety disorders acquisition instructions led increased discrimination fear responses danger cue conditioned stimulus safety cue patients comparison participants moreover instructions strengthened extinction fear responses patient comparison group patients healthy comparison participants better able discriminate danger safety cues explicitly informed cues announce threat situation considering analogies fear extinction procedures exposure therapy suggests specific instructions stimulus threat associations exposure therapy might improve short term treatment efficacy question remains future studies whether instructions positive effect extinction learning longer term
reverse unknown protocol hidden behavior played important role field network security proposed work takes captured messages binary code implement protocol studied object dynamic taint analysis combined static analysis used protocol analyzing firstly monitor analyze process protocol program parses message virtual platform hiddendisc prototype system developed record protocol public behavior based proposed hidden behavior perception mining algorithm static analyze protocol hidden behavior trigger conditions hidden behavior instruction sequences according hidden behavior trigger conditions new protocol messages sensitive information generated hidden behaviors executed dynamic triggering hiddendisc prototype system sense trigger analyze protocol hidden behaviors according statistical analysis results propose evaluation method protocol execution security experimental results show present method accurately mining protocol hidden behaviors evaluate unknown protocol execution security
background measuring agreement gene expression profile known transcriptional regulatory network important step functional interpretation bacterial physiological state way general design principles explored one interpretive framework relationship digital control impact sequence specific interactions analog control extent influence chromosomal structure methods results present time resolved gene expression profiles escherichia coli growth cycle measured rna seq extend methods developed discrete sets differentially expressed genes apply wild type two mutant time series global transcriptional regulators fis hns inactivated test continuous methods using simulated expression profiles generated random boolean network dynamics observe clear trade maximum response level detail included real time course expression data find strong interdependent changes digital analog control exponential growth phase dominance analog control stationary phase conclusions investigation puts forward simple reliable method quantifying match time resolved gene expression profiles transcriptional regulatory network method reveals systematic compensatory interplay digital analog control genetic regulation coli growth cycle
enuresis historically viewed primarily psychiatric disorder understanding changed dramatically since end last century became clear somatic factors nocturnal polyuria result vasopressin deficiency nocturnal detrusor overactivity high arousal thresholds play crucial role enuresis pathogenesis also become clear enuresis inherited majority cases although correlation genotype enuretic phenotype straightforward standard view enuresis result either nocturnal polyuria high arousal thresholds nocturnal detrusor overactivity high arousal thresholds become well established research complicates picture first psychological psychiatric problems overrepresented enuresis might minority cases causal aggravating role second nocturnal polyuria always linked vasopressin deficiency third nocturnal detrusor overactivity pathogenetically heterogeneous could linked constipation fourth sleep enuretic children might deep possibly also disturbed obstructed airways distended contracting bladder children might high arousal thresholds enuresis instead way around might possibly said nocturnal polyuria taking new insights account new model enuresis pathogenesis presented complicated hopefully also true standard consensus
relation thermodynamic parameters obtained water sorption isotherms degree reduction glass transition temperature accompanied water sorption quantitatively studied two well known glassy food materials namely wheat gluten maltodextrin used samples difference chemical potential water solution pure water delta difference chemical potential solid solution pure solid delta change integral gibbs free energy delta obtained analyzing water sorption isotherms using solution thermodynamics parameter delta delta correlated well glass transition temperature dry material taken index plasticizing effect indicates plasticizing effect water foods evaluated parameter delta
objective present study aimed detect levels serum synovial fluid synovial membrane patients knee osteoarthritis koa investigate association severity articular cartilage damage synovitis methods according american college rheumatology criteria osteoarthritis diagnosis cases diagnosed knee koa group selected patients underwent arthroscopic surgery hospital june june additional cases knee joint diseases non koa group included controls levels synovial fluid serum assayed elisa synovial membrane assayed immunohistochemistry severity knee articular cartilage damage synovitis related pathological changes evaluated arthroscopy using outerbridge ayral scores respectively results levels synovial fluid synovial membranes koa group significantly higher non koa group levels synovial fluid synovial membranes positively correlated serum level high sensitivity reactive protein crp outerbridge score ayral score koa group conclusion levels synovial fluid synovial membrane increased koa patients positively correlated koa severity
development organic fluorescent materials great interest fundamental research practical applications piezofluorochromic piezochromic fluorescent material smart material fluorescent properties changed response external pressure stimuli however piezofluorochromic materials depended change physical molecular packing modes remaining extremely rare work new discarbazolyl tetraphenylethylene compound synthesized chemical structures derivative determined nmr elemental analyses properties investigated tga dsc methods results show compound possess piezofluorochromic properties well aggregation induced emission enhancement effect intensity quantum yield dmf high water fraction times higher pure dmf respectively piezofluorochromic nature generated phase transformation crystalline state amorphous state external stimuli organic light emitting diode oled device fabricated compound non doped emitters exhibited good performances maximum brightness maximum current efficiency maximum power efficiency indicated compound multi functional luminophor
paper discusses opportunities well constraints evidence based policy evidence based practice education expectations held different strands public policy makers teachers parents discussed constraint underlying educational research furthermore expectations constrain communication researchers public case science communication relationships educational research evidence based policy communication research public exemplified case studies three topics impact violent computer games relationship class size students learning outcomes issue streaming public schools
background pediatric patients chemotherapy vulnerable invasive fungal infection especially candida spices resistance antifungal agents increased candida spp especially non albicans species study aims assess susceptibility candida spp strains isolated children acute leukemia less years materials methods prospective cross sectional study conducted march march participants children aging month years acute leukemia admitted amir oncology hospital affiliated shiraz university medical science shiraz iran identification candida strains performed using germ tube chlamydospore production tests application programming interface api aux yeast identification system susceptibility testing antifungal agents performed agar based test method fungal cultures carried nose oropharynx stool urine specimens results total yeasts isolated albicans common species found followed krusei parapsilosis glabrata candida species candida glabrata highly resistant yeasts isolated resistant fluconazole itraconazole posaconazole amphotericin ketoconazole conclusion study caspofungin effective antifungal agent colonized candida spp found followed conventional amphotericin knowledge susceptibility patterns colonized candida spp help clinicians managing pediatric patients chemotherapy
aceclofenac non steroidal anti inflammatory drug widely used orthopedics effective management pain inflammation shows poor water solubility short half life hours improve bioavailability aceclofenac hydroxypropyl beta cyclodextrin beta complex prepared characterized improving solubility dissolution overall improvement analgesic anti inflammatory activity aceclofenac complexed beta kneading method fractions coated pvp different time proper mixture dispersion used potential therapeutic activity prepared aceclofenac beta complex showed fold improvement solubility aceclofenachp beta complex pure drug ftir xrpd confirmed complex formation amorphization drug respectively aceclofenac beta inclusion complex showed better dissolution profile pure drug aceclofenac pure drug aceclofenac showed drug release end hand aceclofenac beta complex showed drug release cyclodextrin complex showed analgesia compared analgesia shown standard oral tablet formulation anti inflammatory activity terms inhibition rat paw edema end standard test respectively therefore concluded aceclofenac beta complex may serve prolonged drug delivery system along pvp coating effective management orthopedic pain inflammation
thermal analysis high speed machine necessary made check serviceability temperatures electric machine individual parts influence aspects electric machine design paper deals modeling thermal phenomena high seed asynchronous machine main requirement model easy integration electromagnetic model computational fluid dynamics cfd analysis used determine boundary condition thermal model commonly known high speed machine
reflex seizures evoked specific afferent stimulus activity pathophysiology reflex seizures thought hyperexcitability cortical subcortical neuronal areas respond physiologic stimulus exaggerated manner hyperexcitability could occur due underlying lesions genetic abnormalities present year old latino boy epilepsy autism spectrum disorder developmental impairment reflex seizures triggered water bathing seizures refractory antiseizure medications multiple trials medications vagal nerve stimulator placed desensitization therapy initiated epilepsy gene panel test obtained showed mutation syn gene het arg one publication family syn gene mutation reflex bathing seizures identification correlation may helpful recognition treatment patients families rare presentation
background anaphylaxis acute potentially lethal multisystem syndrome resulting sudden release mast cell derived mediators circulation objectives methods report plasma protease cascade factor xii driven contact system critically contributes pathogenesis anaphylaxis murine models human subjects results deficiency pharmacologic inhibition factor xii plasma kallikrein high molecular weight kininogen bradykinin receptor receptor largely attenuated allergen ige mediated mast cell hyperresponsiveness mice reconstitutions factor xii null mice human factor xii restored susceptibility allergen ige mediated hypotension activated mast cells systemically released heparin provided negatively charged surface factor xii autoactivation activated factor xii generates plasma kallikrein proteolyzes kininogen leading liberation bradykinin evaluated contact system patients anaphylaxis plasma samples immunoblotting revealed activation factor xii plasma kallikrein kininogen acute phase anaphylaxis basal conditions healthy control subjects severity anaphylaxis associated mast cell degranulation increased plasma heparin levels intensity contact system activation bradykinin formation conclusions summary data collectively show role contact system patients anaphylaxis support hypothesis targeting bradykinin generation signaling provides novel alternative treatment strategy anaphylactic attacks
lesbian gay bisexual trans queer people color lgbtq poc regularly exposed unique contextual forms prejudice stigma linked stress increased likelihood mental physical health problems order better understand experiences multiply marginalized population semi structured interviews conducted lgbtq poc examine describe experiences identities communities discrimination health data consisted verbatim interviews guided intersectionality theory minority stress theory analyzed using interpretive phenomenological analysis using intersectionality theory study addresses simultaneity oppressions ways different combinations marginalized identities may impact lgbtq poc well common issues discussed respondents include disconnect communities relationships identities coming stress anxiety primary concepts introduced study include positive intersectionality come stress
investigation veridical mood congruent memory mcm major depressive disorder mdd subject many studies whereas mood congruent false memory received comparatively little attention present study examined influence valence personal relevance valence context learning material true false mcm inpatients mdd healthy controls sixty positive negative neutral personally relevant nouns either combined positive negative neutral adjective word pairs presented participants learning trial recognition task participants identify previously studied word pairs mcm effect could found hits however exploratory analyses word pairs containing personally relevant nouns rated towards old patient relative control group furthermore depressed patients tended rate items towards old controls words presented negative new context results line previous findings depression research emphasizing role mood congruent false memories mood disorders elsevier ireland ltd rights reserved
agriculture intensification use chemical nitrogen fertilizers contributing substantially tremendous increases global food production however eutrophication downstream waters associated excess nitrate pollutant runoff become major environmental concern agricultural areas reservoirs used irrigation well positioned intercept substantial fertilizer runoff upslope agricultural fields authors hypothesized reservoirs used influence quality downstream surface water markov decision process formulated find optimal operating policies controlling stochastic agrochemical pollutant loads reservoirs irrigation model applied irrigation reservoir japan prone nitrate pollution upslope green tea plantations computational results reveal nitrate nitrogen states reservoir storage state optimal policy introduce cleaner water supplements upstream reservoir reservoir storage volume exceeds active capacity nitrate nitrogen concentration less optimal policy would release irrigation water reservoir storage volume exceeds active capacity nitrate nitrogen concentration exceeds optimal operation decision first release irrigation water reservoir introducing cleaner water supplements therefore operation irrigation reservoirs optimized control intercepted agro fertilizer pollutants intensive agricultural areas developed method reservoir irrigation operation potential support decision making processes provide greater protection water environment agrochemical pollution sustaining productivity intensive agricultural areas elsevier ltd rights reserved
first study deals one dimensional problem scattering electromagnetic waves obstacle coated thin ferromagnetic layer ferromagnetic materials nonlinear behavior widely used stealth technology absorbing coatings objective derivation stability analysis numerical approximation effective boundary conditions permit simulation least approximatively effect thin layer avoiding discretization maxwells equations inside layer
several risk factors identified appear consistently strongly associated development atopic dermatitis family history atopy inherited genetic predisposition active passive exposure tobacco smoke recent studies also demonstrated simple intervention birth daily application emollient moisturizer seems protect susceptible infants development published frontline medical communications
backgroundchrysanthemum indicum oriental medicinal plant shown display variety pharmacological activities including antibacterial anti inflammatory effects aimsin study evaluated ability indicum extracts inhibit vitro tyrosinase activity skin care effects cosmetic formulations containing indicum water extract human volunteers patients methodsthe formation dopachrome dopa mushroom tyrosinase observed treatments indicum extracts volunteers received placebo extract test indicum water extract cosmetic cream applied face three times day weeks biophysical skin parameters measured every weeks resultschrysanthemum indicum methanol water extracts dose dependently inhibited mushroom tyrosinase activity effects methanol extract similar kojic acid well known tyrosinase inhibitor clinical evaluations revealed application cosmetic formulations containing indicum water extract time dependently reduced melanin levels weeks whereas placebo group showed effect changes moisture elasticity wrinkles evenness pore size observed either group hplc dad esims analyses revealed luteolin acacetin rutinoside major flavonoid compounds indicum water extract conclusionthese results suggest indicum water extract could applied natural skin whitening agent functional cosmetic uses due melanin reducing efficacy
migraine characterized severe headaches preceded aura likely caused cortical spreading depression antiepileptic pregabalin lyrica shows clinical promise migraine therapy although efficacy mechanism action unclear detected diffusion weighted mri mri wildtype mice acute systemic administration pregabalin increased threshold initiation vivo familial hemiplegic migraine type mutant mice expressing human mutations type calcium channel subunit pregabalin slowed speed propagation vivo acute systemic administration pregabalin vivo also selectively prevented migration subcortical striatal hippocampal regions strain exhibits milder phenotype gain channel function cellular level pregabalin inhibited glutamatergic synaptic transmission differentially mice study describes mri analysis method tracking progression provides support mechanism action pregabalin possible effective therapy treatment migraine
written previously allure hazards promise love siren call luring terrible dangers charles intense intimacy analytic environment also regressive pulling primitive memories heightened sensory quality often early experiences frustrated desire psychoanalytic psychotherapy invites patient transfer feelings childhood later life onto analyst coming contact primitive forbidden longings helps individual make sense forces drive thinking action powerful forces unleashed consulting room must place safety fantasies enacted without fear actualizing analyst feels regressive desires must able stand ground allow transference unfold patient encounter longings desire work way rather expecting filled consulting room two cases described boundaries broken patients sought assistance dealing sequelae cases remind desires perfect parent analyst obstructive destructive lose analytic mind move realm transgressive enactment rather preserving space working
reliability integration tillage machine design process new strategy overcome drawbacks classical design approaches achieve designs required reliability level furthermore design optimization soil tillage equipments uncertainty seeks design structures economic reliable originality research develop efficient methodology controls reliability levels complex statistical distribution cases random tillage forces developed strategy based design sensitivity concepts order determine influence random parameter application method consists taking account uncertainties soil tillage forces tillage forces calculated accordance analytical model mckyes ali modifications include effect soil metal adhesion tool speed different developments applications show importance developed method improve performance soil tillage equipments considering random geometry loading parameters developed method called osf optimum safety factor satisfy required reliability level without additional computing time relative deterministic design optimization study since agricultural equipment parameters extremely nonlinear extended osf approach several nonlinear probabilistic distributions lognormal uniform weibull gumbel probabilistic distribution laws elsevier rights reserved
mode division multiplexing mdm promising technology increasing aggregate bandwidth multimode fiber mmf conjunction wavelength division multiplexing wdm face impending capacity crunch optical fiber networks paper investigates effect radial azimuthal mode spacings channel mdm wdm system mmf using spatial light modulator controlled vcsel array excitation laguerre gaussian modes data rate gbps achieved central wavelength effects different azimuthal radial mode spacings modes analyzed terms channel impulse response eye diagram bit error rate
background purpose estimate prevalence insomnia symptoms syndrome general population describe types self help treatments consultations initiated insomnia examine help seeking determinants patients methods randomly selected sample french speaking adults province quebec canada responded telephone survey sleep insomnia treatments results total sample dissatisfied sleep reported insomnia symptoms met criteria insomnia syndrome thirteen percent respondents consulted healthcare provider specifically insomnia lifetime general practitioners frequently consulted daytime fatigue psychological distress physical discomfort main determinants prompting individuals insomnia seek treatment total sample used least herbal dietary products facilitate sleep used prescribed sleep medications year preceding survey self help strategies employed facilitate sleep included reading listening music relaxation conclusions findings confirm high prevalence insomnia general population insomnia sufferers seek professional consultations many individuals initiate self help treatments particularly daytime impairments fatigue become noticeable improved knowledge determinants help seeking behaviors could guide development effective public health prevention intervention programs promote healthy sleep elsevier rights reserved
background onychomycosis fungal infection nail plate subungual area study examined efficacy laser treatment using self controlled study programs involving long pulsed yag laser combined oral medication methods self controlled strategies followed study patients received treatment oral itraconazole conjunction long pulsed yag laser treatment nails unilateral limb week total four times total affected nails divided group mild moderate group severe according disease severity affected nails scoring clinical index onychomycosis scores selected compare therapeutic effects pure medication treatment group combination treatment group week follow period results group weeks follow efficacies pure medication treatment group respectively combination treatment group respectively differences groups significant week chi week chi week chi group weeks follow efficacies pure medication treatment group respectively combination treatment group respectively differences groups weeks follow statistically significant week chi week chi conclusions patients mild moderate onychomycosis recommended pure medication treatment combination treatment medication laser patients severe onychomycosis recommended combination medication laser therapy
lead public drinking water supplies garnered much attention since outset flint water crisis known hazard multiple environmental matrices exposure results long term deleterious health effects humans discussion paper aims provide succinct account environmental exposures focus water levels wlls united states understood strong correlation wlls blood levels blls associated health effects however within flint water crisis water chemistry exposure occurred cascade regulatory bureaucratic failures culminated flint water crisis paper discuss pertinent regulations responses including limitations overview public health effects exposure well discussion limitations monitoring mitigating tap water flint water crisis also included increased legionnares disease caused legionella pneumophila paper discuss factors influencing pneumophila growth highlight systemic nature changes water chemistry public health impacts critically analyze important aspects water research offer discussions stimulate future water quality research new systemic perspective inform guide public health decision making elsevier rights reserved
paper presents results study regarding influences cutter inclination cutting force case stems rods energetic willow salix viminalis var energo original research method proposed means original equipment designed manufactured laboratories politechnica university timisoara experiments made inger variety controlled moisture content diameter rods special cutting device integrated testing system strength materials zwick roell insures cutting speed constant four cutter inclination levels tested sexagesimal degree time cutting surface quality observed moisture content controlled results experiments analyzed determine relationship cutting force cutter inclination also optimal parameters maximum cutting force used drive pneumatic system design knife cutting module integrated complex equipment sorting packaging src rods nurseries
intense anthropogenic pressure native media causing grave ecological problems deficiency drinking water shift natural evolution ecosystems due species extinction emphasizes need accurate analytical systems continuous environmental monitoring microorganisms simple sensitive living units conducting nutrient metabolic cycles environment applicable proper assessment ambient media state paper review modes microbial contribution indication list important standard micro indicators water pollution article describe date direct methods pollutant detection indirect indicator recognition techniques peculiarities requirements water quality monitoring correlated high dynamics mobility aqueous media discussed
background transcription factor ets highly expressed lymphocytes loss ets leads premature cell differentiation antibody secreting cells ascs secretion autoantibodies development autoimmune disease despite importance ets cell biology ets target genes known cells results obtain complete picture function ets regulating cell differentiation performed ets chip seq primary mouse cells identify binding sites many localized near genes play important roles cell activation differentiation although ets bound many sites genome required regulation less evidenced gene expression changes cells lacking ets cohort genes whose expression altered included numerous genes associated autoimmune disease susceptibility focused attention four ets target genes ptpn stat egr prdm assess might contribute ets function limiting asc formation found dysregulation particular targets explain altered asc differentiation absence ets conclusion identified genome wide binding targets ets cells determined relatively small number putative target genes require ets normal expression interestingly cohort genes associated autoimmune disease susceptibility among regulated ets identification target genes ets cells help provide clearer picture ets regulates cell responses loss promotes autoantibody secretion
south african construction industry suffered loss many qualified middle management level project managers recent years resulted many young inexperienced project managers forced manage large complex projects addition senior project managers still practising locally busy mentor guide younger project managers due shortage professionals local industry article reports study done identify important attributes influence project success south african construction industry extracting list factors identified existing literature grouping factors six main categories category contains six factors questionnaire compiled distributed via online survey tool data analysed using statistical methods including concordance correlation results indicated interpersonal factors considered important category followed application theory personal contribution personal character considered least important categories however important attributing factors communication skills leadership style neither listed top two categories general low level concordance achieved confirming belief level knowledge experience mutual agreement among participants industry low
background cold spells heatwaves increase mortality however little known effect heatwaves cold spells cardiovascular morbidity study aims assess effect cold spells heatwaves cardiovascular diseases mediterranean region catalonia southern europe methods conducted population based retrospective study data obtained system development research primary care catalan meteorological service outcome first emergency hospitalizations due coronary heart disease stroke heart failure exposures cold spells cold spells subsequent days heatwaves incidence rate ratios irr confidence intervals calculated using self controlled case series method accounted age time trends air pollutants results shown age groups gender cardiovascular event type results cardiovascular hospitalizations winter summer overall incidence cardiovascular hospitalizations significantly increased cold spells irr effect even stronger days subsequent cold spell irr conversely cardiovascular hospitalizations increase heatwaves neither overall stratified analysis conclusions cold spells heatwaves increased incidence emergency cardiovascular hospitalizations catalonia effect cold spells greater including subsequent days knowledge might useful develop strategies reduce impact extreme temperature episodes human health
aim work study influence binary ternary combinations bovine plasma proteins bpp inulin carrageenan overall quality fat reduced sausages influence components different properties chemical composition weight loss cooking emulsion stability texture profile sensory analysis fat reduced sausages studied compared two samples one without fat reduction another fat reduced sample without addition texturing agents sense full factorial experimental design two levels central point used samples containing bpp bpp showed synergy binary combinations presented higher values moisture protein content samples containing individual components reduction fat content increases values hardness decreases values springiness samples bpp binary combinations bpp bpp best stability values low total fluid loss demonstrating significant synergistic effect combining bpp similar results obtained study weight loss cooking however studies showed destabilization sample bpp emulsion stability decreased weight loss increased cooking compared binary combinations less acceptable sample flavor texture one containing bpp however bpp combined major acceptability obtained demonstrating synergistic effect binary combinations therefore studies revealed binary combinations bpp good alternatives development fat reduced sausage
objective children health insurance program chip authorized ushering unprecedented focus children health care quality one includes identifying core set performance measures voluntary reporting states medicaid chip programs however wide variation quantity quality measures states chose report center medicare medicaid services cms objective study assess reporting barriers identify potential opportunities improvement methods questionnaire developed coordination cms agency healthcare research quality ahrq sent state medicaid chip officials assess barriers child health quality reporting federal fiscal year states categorized high medium low reporting comparative analysis results twenty five states district columbia agreed participate study completed questionnaire states placed high priority children health care quality reporting point likert scale plan use measurement results improve quality initiatives however low reporting states believed inadequate staffing data collection extraction time consuming high reporting states conclusion based state responses possible solutions improve reporting includes funding staff support refining technical assistance provided creating venues state state interaction realistic tangible improvements within reach opportunities cms states collaborate improve child health care quality elsevier inc rights reserved
nowadays researchers pay attention microwave absorbing materials increase electromagnetic pollution development stealth technology military platforms traditional microwave absorbers ferrite metal powder conductive magnetic fibers magnetic flake powder nanoparticles facing common problems large specific gravity narrow absorption bandwidth large match thickness poor absorption performance composites core shell structures becoming promising microwave absorbing material structure exhibit magnetic dielectric characteristics proper selection core shell materials thus deposition srfeo surface considered fabrication new composite possesses advantages two materials new composite might also obtain remarkable microwave absorption thin layer absorbers entire similar ghz frequency range srfeo composites core shell structures prepared metal organic chemical vapor deposition mocvd using srfeo iron pentacarbonyl precursors xrd sem eds vector network analyzer used characterize structure electromagnetic properties samples structure morphology analyses show composites complete core shell structures srfeo core layers shell nanoparticles uniformly deposited surface srfeo thickness reaction temperature degrees flow rate min simulation studies show srfeo electromagnetic properties changed significantly absorbing properties got evidently improvement deposited surface samples prepared deposition time min best absorbing properties reflection loss value exceeding range similar ghz frequency obtained selecting appropriate thickness absorber layer moreover minimum obtained thick layer deposited srfeo mocvd significantly improve electromagnetic properties srfeo srfeo composites could used effective microwave absorption material
present neuroimaging study investigated two aspects difficulties emotion associated borderline personality disorder bpd affective lability difficulty regulating emotion two characteristics previously linked bpd symptomology remains unknown whether individual differences affective lability emotion regulation difficulties subserved distinct neural substrates within bpd sample address issue sixty women diagnosed bpd scanned completing task assessed baseline emotional reactivity well top emotion regulation affective instability measured affective lability scale als positively correlated greater amygdala responses trials assessing emotional reactivity greater difficulties regulating emotion measured difficulties emotion regulation scale ders negatively correlated left inferior frontal gyrus ifg recruitment trials assessing regulatory ability findings suggest within sample individuals bpd greater bottom amygdala activity associated heightened affective lability contrast difficulties emotion regulation related reduced ifg recruitment emotion regulation results point distinct neural mechanisms different aspects bpd symptomology elsevier ireland ltd rights reserved
nowadays protection security data transited within computer networks represent real challenge developers computer applications network administrators intrusion detection system intrusion prevention system reliable techniques good security detected intrusion based data collection collection important significant traffic monitored systems interesting feature thus first task intrusion detection system intrusion prevention system collect information basis treat analyze make accurate decisions network analysis used improve networks performances security also used malicious tasks main goal article design reliable powerful network sniffer called pcapsocks based pcap language sockets able intercept traffic three modes connected connectionless raw mode start performances assessment performed list expanded recently used network sniffers study completed classification sniffers related computer security objectives based parameters library libpcap winpcap libnet filtering availability software hardware alert real time pcapsocks provides nice performance integrating reliable sniffing mechanisms allow supervision taking account low high level protocols tcp udp network communications
background atrial fibrillation common cardiac arrhythmia associated increased cardiovascular morbidity mortality including thromboembolic events aims study assess prevalence left atrial appendage laa thrombi japanese non valvular atrial fibrillation nvaf patients undergoing preprocedural transesophageal echocardiography tee anticoagulation therapy compare efficacy warfarin direct oral anticoagulants doac methods results retrospective study reviewed records consecutive nvaf patients men age years undergoing preprocedural tee following least weeks anticoagulation therapy patients non paroxysmal laa thrombus observed patients prevalence laa thrombi similar doac group warfarin group patients cha vasc score paroxysmal without prior stroke transient ischemic attack laa thrombi univariate analysis non paroxysmal structural heart disease antiplatelet therapy larger left atrium higher brain natriuretic peptide bnp reduced laa flow higher cha vasc score associated laa thrombi multivariate analysis bnp remained independent predictor laa thrombi conclusions laa thrombi found japanese nvaf patients scheduled procedures despite ongoing oral anticoagulation therapy incidence thrombi similar patients doac warfarin
location aware services las special context aware services recommend suitable services user based user location however considerable uncertainty exists detecting user location previous studies rarely discussed uncertainty emphasized timeliness efficiency systems therefore fuzzy collaborative problem solving strategy used enhance performance ubiquitous las system measured according timeliness service efficiency recommendation process uncertainty detecting user location using gps first considered modeling location speed user fuzzy numbers considering uncertain parameters fuzzy mixed integer programming problem formulated determine timely service location path user however fuzzy mixed integer programming problem easy solve therefore fuzzy collaborative problem solving strategy used decompose fuzzy mixed integer programming problem smaller pieces handled separate processing modules favorable path user also leads user region multiple service locations instead single service maximize total timeliness elaborate effectiveness proposed methodology experiment conducted downtown taichung city taiwan based experimental results proposed methodology able used determine timely service location specific user revealed reduced average waiting time proposed methodology also reduced time necessary find timely location path contributed enhanced efficiency elsevier ltd rights reserved
application smart grid produces massive data unfortunately traditional analysis power systems process huge volume data efficient manner distributed computing like map reduce framework cloud environment provide promising solution problem processing data parallel large amount computing nodes paper parallelize power flow calculation based map reduce programming framework evaluate efficiency classic newtonraphson method commonly used power flow calculation totally parallelized solve sparse linear equations map reduce framework factorization tree carefully partitioned turn variables subtrees independent calculated parallel moreover map proposed algorithm mapreduce jobs also define appropriate formats input intermediate output data experimental results demonstrate effectiveness proposed scheme
preclinical toxicity testing animal models cornerstone drug development process yet often unable predict adverse effects tolerability issues human subjects species specific responses investigational drugs led researchers utilize human tissues cells better estimate human toxicity unfortunately human cell derived models imperfect toxicity assessed isolation removed normal physiologic microenvironment microphysiological modeling often referred organ chip human chip places human tissue microfluidic system mimics complexity human invivo physiology thereby allowing toxicity testing several cell types tissues organs within biologically relevant environment describe important concepts developing repro chip model development female male reproductive microfluidic systems critical sex based invitro toxicity drug testing review addresses biological physiological aspects male female reproductive systems invivo considered designing microphysiological human chip model additionally interactions reproductive tract systems explored focusing impact factors hormones produced reproductive tract disease pathophysiology
paper present codecraft educational video game developing teach fundamentals computer programming similar educational tools scratch alice project spark code spells codecraft provides users intuitive graphical interface writing programs however codecraft video game uses problem based learning approach players learn programming concepts solving individual puzzles immersive environment moreover codecraft intended autonomous learning game played without teacher support thereby potentially reaching students economic ethnic gender groups using iterative development process evidence centered design work proposes develop codecraft evaluate improve performance acquiring programming skills
transposable elements tes constitute dynamic largest component large plant genomes example maize genome wheat genome may tes novo annotation therefore computational challenge investigated using current tools repet package new strategies overcome difficulties tested methodological developments sequence chromosome hexaploid wheat chromosome similar one fattest genomes ever sequenced successfully established various strategies annotating tes complex dataset analyses show strategies overcome current limitations novo discovery large plant genomes relative annotation based library known tes novo approaches improved genome coverage number full length annotated copies also developed two new metrics qualifying annotation nte involves measuring number lte smallest sizes annotations cover genome nte decreased number annotations lte increased work shows obtain comprehensive high quality automatic annotation number economically agronomically important species
people living hiv aids phas increasingly recognized experts hiv health developed simulated clinical encounter sce medical students provided hiv pre post test counselling point care hiv testing phas patient instructors pha pis clinical preceptor supervision study assessed acceptability teaching tool focus assessing impact hiv related stigma among medical students university toronto pre clerkship medical students participated series sces facilitated pha pis clinical preceptors pre post sce students completed validated health care provider hiv aids stigma scale hpass hpass measures overall stigma well three domains within hiv stigma stereotyping discrimination prejudice higher scores represented higher levels stigma additional questionnaire measured comfort providing hiv related care mean scores results paired tests presented post sce students demonstrated decreased overall stigma well decreased stigma within domain post sce students reported increased comfort providing hivrelated care involving pha pis reduced hiv related stigma among medical students increased comfort providing hiv related care
paper presents results centrifuge study performed investigate time dependent behavior geotextile reinforced soil walls effect reduced scale centrifuge models built using nonwoven fabrics reinforcement elements monterey sand backfill digital image analysis techniques used quantify internal displacements within reinforced zone sand markers placed along reinforcement layers sigmoid function found provide adequate fit raw displacement data allowing estimation strain distribution along reinforcement layers investigation includes initial series centrifuge models designated short term tests loaded failure continuously increasing acceleration imparted addition series models designated long term tests conducted subjecting constant accelerations corresponding level failure obtained short term tests results revealed walls subjected constant acceleration showed time dependent behavior adversely affected stability considerable time dependent deformations observed occur long term tests time dependent deformations reinforcements quantified using geosynthetic samples tested isolation found also develop confinement centrifuge models particular creep failure observed long term models subjected comparatively high levels constant acceleration time dependent deformations confined geotextiles tested centrifuge testing program compared results unconfined geotextiles tested conventional creep testing program time failure defined using data centrifuge tests found consistent obtained conventional creep tests soil used centrifuge models study frequently considered negligible creep ultimately found prevent development time dependent deformations elsevier ltd rights reserved
history ever smoking appears associated severe disease phenotype axial spondyloarthritis axspa however evidence sparse effect increased smoking exposure disease outcomes whether smoking reduction cessation improves outcomes aim study explore whether dose response relationship exists pack years disease activity functional impairment axspa consecutive patients meeting asas criteria axial spa recruited spondyloarthritis service associations pack years smoking disease activity basdai asdas spinal pain functional impairment basfi inflammatory markers explored using multivariable linear models adjusted age gender use tnf inhibition tnfi therapy pack years categorised four groups analysed light smoking beta higher basfi beta beta higher asdas beta cross sectional study demonstrated smoking associated increased axspa severity markers dose response manner particular effort made restrict smoking exposure early accruing significant number pack years
background aimboth sarcopenia low serum testosterone associated increased mortality men cirrhosis known variables interact methodswe conducted retrospective longitudinal cohort study men referred liver transplant evaluation baseline demographics included hormone profile model end stage liver disease meld score baseline computerized tomography reformatted calculate skeletal muscle area using validated tomovision software based methodology primary outcome time death liver transplantation resultsmedian testosterone low nmol ref nmol muscle mass ref muscle mass correlated serum testosterone tau meld score tau separate multivariable models sarcopenia hazard ratio low testosterone significantly associated mortality independent meld score variables meld score muscle area testosterone entered single model low testosterone sarcopenia remained significantly predictive mortality respectively conclusionlow testosterone sarcopenia associated increased mortality men advanced liver disease may identify patients high risk mortality would missed meld score alone low testosterone appears better predictor mortality sarcopenia simpler test improve prognostic value meld score interventional trials required determine whether low testosterone sarcopenia markers mediators mortality population
hepatitis virus hcv promotes lipid droplet formation perturbs expression associated pat proteins adrp tip promote lifecycle hcv enhances tip suppresses adrp displacing surface infected cell models previously shown suppression tip mir mir decreased intracellular lds hcv rna thus study aimed examining whether microrna mediated suppression hcv would limit hcv dependent displacement adrp lds adrp expression examined hcv infected liver biopsies healthy donor liver tissues well hcv infected huh cells using qrt pcr mir mir expression manipulated using specific oligos jfh infected oleic acid treated cells study impact adrp expression using qrt pcr immunofluorescence microscopy intracellular hcv rna assessed using qrt pcr adrp regulated patients well hcvcc jfh infected cell models forcing expression mirnas induced adrp mrna protein levels study shows hcv suppresses hepatic adrp expression infected patients cell lines forcing expression mir mir limits suppressive effect hcv adrp wiley periodicals inc
korteweg vries kdv type equations describe nonlinear waves fluids plasmas etc paper two generalized kdv equations investigation bilinear forms constructed bell polynomials auxiliary variable soliton solutions given hirota direct method via asymptotic analysis soliton interactions first generalized kdv equation analyzed turn elastic singular breather solutions derived two soliton solutions collision soliton singular breather appears elastic bound states soliton singular breather exhibited unlike first one generalized kdv equation support bound states solitons regular singular solitons alike
purpose objectives article describes value clinical nurse specialist cns team partnering interdisciplinary stakeholders improve care women gynecological cancers receiving radiation via intracavitary interstitial pelvic implants ipi background intracavitary interstitial pelvic implants prolong survival associated significant impacts quality life intracavitary interstitial pelvic implants complex invasive intervention requires patients immobile days creates challenges related dignity hygiene nutrition pain management emotional health skin care overall patient satisfaction nursing staff shared concerns respective cnss regarding patients quality care lack standardized practice orders gaps knowledge created challenges rationale clinical nurse specialist practice requires collaborative efforts within spheres influence improve care patients receiving ipi therapy description cnss recognized addressed needs patients families staff organization across continuum team efforts relied reflection nurses concerns collaboration unified vision exceptional care outcomes cns led initiative successful establishing processes ensure quality care improvement patient care achieved creation standardized order sets focused plan care patient family staff education nurse satisfaction confidence empowerment provide patient care dignity sensitivity verbalized conclusion cns team broad scope practice across inpatient outpatient evidence based practice strength key team success recognition challenges unified vision bring together stakeholders facilitate improvement care future direction includes evaluating nutritional choices examining psychosocial aspects patient experience interdisciplinary nursing grand rounds planned highlight outcomes team implications leadership cns teams varied scopes critical affecting change within spheres influence improving patient care across continuum
background genetic influences self medication counter otc drugs merit investigation example patients frequently use otc nonsteroidal anti inflammatory drugs nsaids treat inflammation inflammatory response also affected endogenous cytokines whose production varies across polymorphisms encoding genes case interleukin literature suggests single nucleotide polymorphism snp promoter region cytokine gene influences production higher levels associated variant alleles objective demonstrate feasibility researching role genetics self medication using existing national survey data evaluate possible association otc nsaid use genotype snp gene methods statistical analyses performed using data participants third national health nutrition examination survey nhanes iii results otc nsaid use aspirin ibuprofen previous month significantly common among persons genotypes snp odds use consistently increased relative number alleles trend remained statistically significant odds ratio per additional allele confidence interval adjustment confounding conclusions analysis population based genetic data suggests association common self medication behavior specific genetic polymorphism findings broadly demonstrate nhanes data provide opportunities investigate associations specifically imply potential interrelationships among otc nsaid use genotype cytokine levels deserve study
rule based classification systems constructed upon linguistic terms antecedent consequent rules lack sufficient generalization capabilities paper proposes new multivariate fuzzy system identification algorithm design binary rule based classification structures making use repulsive forces cluster prototypes different class labels approach coupled potential discrimination power dimension feature space increase generalization potential address issue first multivariate variant newly proposed soft clustering algorithm along mathematical foundations proposed next discriminatory power individual feature computed using multivariate membership values proposed clustering algorithm achieve accurate firing degree rule main advantage method handle unbalanced datasets yielding superior true positive measure keeping false positive rate low enough avoid natural bias toward class labels containing larger number training samples validate proposed approaches series numerical experiments publicly available datasets real clinical dataset collected team conducted simulation results demonstrated achievement primary goals research elsevier rights reserved
promotion spinal fusion using bone autografts largely mediated osteoinductive potential progenitors mesenchymal stem cells msc reside marrow spaces cancellous bone iliac crest common autograft donor site use presents increased risk donor site pain morbidity infection degenerative bone samples harvested facetectomy might provide alternative viable source osteoinductive autografts study conducted intra individual comparison osteogenic potential isolated low passage msc sources iliac crest degenerative facet joints harvested eight consecutive patients undergoing transforaminal lumbar interspinal fusion due lumbar spinal stenosis msc isolated collagenase digestion selected plastic adherence minimally expanded downstream assays clonogenic osteogenic potential evaluated colony formation assays control osteogenic culture medium osteogenic properties including alkaline phosphatase alp induction matrix mineralization type collagen mrna protein expression characterized using quantitative histochemical staining reverse transcription pcr spontaneous adipogenesis analysed adipocyte enumeration gene expression analysis adipogenic markers average colony forming efficiency osteogenic medium equal iliac crest facet joint osteogenic potential clonal level iliac crest facet joint msc respectively clonogenic osteogenic potential significantly negatively associated donor age osteogenic differentiation led significant induction alp activity iliac crest sixfold facet joint eightfold msc matrix mineralization quantified alizarin red staining increased osteogenic differentiation yet similar msc sources protein expression type collagen enhanced osteogenesis significantly greater iliac crest msc correspondingly cola mrna expression higher osteogenically differentiated msc iliac crest adipocyte numbers showed significant differences iliac crest facet joint msc osteogenic conditions negative grem positive fabp adipogenic markers differentially expressed sources msc iliac crest degenerative facet joints largely display similar clonogenic osteogenic properties vitro differences molecular level likely impair osteoinductive capacity facet joint msc bone autografts facetectomy would viable alternatives bone autografts intervertebral spinal fusion lumbar spinal stenosis
knowledge representation plays important role designing knowledge base systems well intelligent systems nowadays many effective methods representing semantic network rule base systems computational network computational objects knowledge base cokb used represent total knowledge design knowledge base systems fact popular form knowledge domain knowledge operations computational relations especially computational knowledge domain linear algebra analytic geometry however cokb model models solved yet problems operators specification operator properties operator reducing expression paper present reducing model cokb model called ops model represents knowledge operators objects solve problems related operators algorithms designing inference engine model built moreover ops model applied specify part knowledge domain direct current electrical circuits construct program solving problems knowledge domain
study describes engagement veterans dementia evidence based care coordination intervention called partners dementia care pdc pdc uses person centered approach encourages participation individuals dementia iwds despite cognitive impairment pdc also targets primary family friend caregivers often main user program total iwds passed mental status screening considered engagement potential study actual engagement based data iwds pdc records combined data structured research interviews approximately iwds engagement potential minimum level actual engagement pdc smaller subsample actively engaged indicated assigned accomplished action steps younger iwds self reporting memory difficulties higher levels engagement results describe one example extent limits iwd engagement psychosocial interventions
autism spectrum disorders asd developmental disorders characterized behavioral deficits verbal nonverbal communication well social interactions accompanied repetitive stereotyped behaviors interests numerous studies last forty years recognized altered immune responses individuals asd concurrently basic research highlighted myriad neuroimmune interactions cross talk occurs nervous immune systems neuroinflammation particularly cerebellum found post mortem brain tissues individuals asd characterized presence profound glia activation processes altered gene expression profiles indicating perturbed immune suggest contributing role immunological systems pathology asd peripheral immune abnormalities also found shifts direction skewing reported well autoantibody production increased cell activation cell responses monocyte cell function overwhelmingly suggesting presence immune dysfunction individuals asd many findings associated worsening behavioral scores suggesting treatment immune function could useful alleviating symptoms associated asd immune activation utero also associated increased risk child diagnosis asd increased cytokine production offspring directly linked changes offspring behavior addition peripheral changes brain csf immune variations asd reported well increase gastrointestinal mucosal dysfunction led increased interest exploring gut brain immune connections role asd research neuroimmune interactions may bring insight elicit new therapeutic tools asd
low water availability several regions southeastern hellas particularly several islands crete resulted construction various types water reservoir collection storage rainwater since early habitation since technologies construction use several types cisterns developed crete minoan era water cisterns well practiced basic means water supply several settlements minoan water cistern technologies developed mainly enlargement scale water systems subsequent stages hellenic civilizations furthermore advanced water cistern technologies invented peak hellenistic period followed alexander great time spread geographical area hellas west east romans inherited cistern technologies developed mainly changing application scale small large characteristic paradigms cretan cisterns considered justify significance technology water supply areas low water availability whole cretan history herein nowadays climatic conditions water resources management crete presented discussed
integrated global positioning system gps satellite digital audio radio sdars antenna proposed automotive use gps antenna formed modifying annular ring antenna operating mode sdars antenna placed ring center using slot loaded degenerate mode square patch gps antenna operates mhz right hand circular polarization sdars antenna operates mhz left hand circular polarization antenna also placed automotive model simulations vehicle performed simulations measurements antenna exhibit good performance automotive use
since mirror neurons introduced neuroscientific community years ago become elegant intuitive account different cognitive mechanisms empathy goal understanding conditions autism spectrum disorders recently mirror neurons suggested mechanism underlying specific type synesthesia mirror touch synesthesia phenomenon individuals experience somatosensory sensations seeing someone else touched appealing careful delineation required applying mechanism using mirror touch synesthesia case put forward theoretical methodological issues addressed relying mirror neurons account
alternative fuels internal combustion engine ice recently become attention due concern environmental protection needs reducing dependency fossil fuels meeting current stringent regulation alcohol fuel one attractive alternative fuels produced renewable resources oxygenated methanol fuel well known alcohol fuel blended lower blending ratio gasoline produce better engine operation spark ignition engine however problem related methanol properties especially energy content vapour lock characteristics alcohol higher carbon number iso butanol high energy content able displace petroleum gasoline compared methanol gasoline blended fuel study focus effect iso butanol additive methanol gasoline fuel unmodified spark ignition engines lower ratio methanol gasoline blends blended isobutanol additive increment compared base gasoline fuel tests conducted constant load variable lower engine speed range rpm rpm results indicate engine performance displayed improvement engine brake power bte brake thermal efficiency egt exhaust gas temperature compared blended fuels nevertheless higher fuel consumption recorded methanol gasoline blended fuels iso butanol additive compared base gasoline fuel terms engine emissions gives significant reduction emissions compared base gasoline fuel however increasing trend projected nox emissions recorded iso butanol additive methanol gasoline fuels exerting highest emissions concluded iso butanol additives viable option blended existing lower ratio methanol gasoline spark ignition engine operation alternative fuel elsevier ltd rights reserved
electrical network measurements usually sent control centers using specific communication protocols however measurements contain uncertainties due meters communication errors noise incomplete metering unavailability measurements aim state estimation estimate state variables power system minimizing measurement errors available control center past many traditional algorithms based gradient approach used purpose paper discusses application artificial intelligence algorithm particle swarm optimization pso solve state estimation problem within power system two objective functions formulated weighted least square wls weighted least absolute value wlav effectiveness pso another optimization algorithm genetic algorithm shown comparing two solutions true state variable values obtained using newton raphson algorithm elsevier rights reserved
internet worm infection continues one top security threats widely used botnets recruit newbots order defend future worms important understand worms propagate different scanning strategies affect worm propagation dynamics study present stochastic continuous time markov chain model characterizing propagation internet worms model developed uniform scanning worms local preference scanning worms flash worms specifically uniform local preference scanning worms able provide precise condition determines whether worm spread would eventually stop obtain distribution total number infected hosts using modeling approach reveal underlying similarity relationship uniform scanning local preference scanning worms finally validate model simulating propagation worms
tuberculosis remains threat public health second cause death due single infectious agent hiv aids worldwide distribution heterogeneous incidence decreasing high income regions situation remains worrying many parts world emergence mycobacterium tuberculosis strains resistant key agents used treatment rifampin isoniazid contributes transmission around world achieve elimination high low endemic countries must upscale efforts decrease disease transmission improve cure rates management drug resistant particular importance paper discuss different models care multidrug resistant mdr ethical considerations specific constraints present high income countries management model chosen belgian specialists accordance public health authorities well building specific mdr xdr isolation unit also discussed
work refers innovative system inspired nature mimics thermoregulation system exists animals method called anti bacteria heat exchanger abhe proposed achieve continuous thermal disinfection bacteria hot water systems high energy efficiency particular study aims demonstrate opportunity gain energy means recovering heat plate heat exchanger firstly thermodynamics abhe clarified define abhe specification secondly first prototype abhe built specific configuration based simplicity regarding design construction thirdly experimental test carried finally computer model built simulate abhe system experimental data used validate model experimental results indicate performance abhe system strongly dependent flow rate supplied temperature less effect experimental simulation data show large potential saving energy thermal disinfection method recovering heat exemplify supplying water flow rate min temperature degrees heat recovery required pumping power means pressure drop small compared energy recovered consequently high saving total cost promising elsevier ltd rights reserved
responsive copolymer hydrogel synthesized based methyl methacrylate mma methacrylic acid maa monomers adopted nanoreactor assembling nanoparticles fourier transform infrared spectroscope ftir scanning electron microscopy sem transmission electron microscope tem visible spectroscopy vis thermogravimetric analysis tga used fully characterize formation silver nanoparticles mma maa hydrogels experimental results showed mma maa hydrogels assume three networks architecture morphologies nearly spherical nanoparticles formed hydrogel networks size nanoparticles varies system composition swelling kinetics investigations demonstrated equilibrium swelling ratio esr mma maa hydrogels depended content maa buffer solutions esr values reduced increasing maa contents antibacterial properties aureus subtilis bacteria demonstrated mma maa silver nanocomposite hydrogels higher antimicrobial efficacy pure mma maa counterparts therefore nanocomposite hydrogels turned potentially smart material range applications antibacterial activity
paper explores link presence unions workplace adoption decentralized labor agreements technical efficiency using large sample italian manufacturing firms apply data envelopment analysis robust version based bootstrap theory get reliable estimates technical efficiency firm level standard first stage devote particular attention specific technology adopted distinguishing different sector frontiers well presence outliers obtained efficiency scores analyzed second stage applying truncated regression model estimated via maximum likelihood following simar wilson methodology results highlight presence workplace unionization decreases level technical efficiency aspects limiting unions power strong exposure international markets high debt levels prevalence flexible assets partially reduce negative effect however firms adopt decentralized labor contracts agreements effect efficiency positive partially compensates negative unions effect elsevier rights reserved
pathomorphological study trephinobiopsy specimens patients lymphoproliferative myeloproliferative diseases carried course chemotherapy combinations initial manifest myelofibrosis loose network reticulin fibers extensive network reticulin collagen fibers respectively predominated debut chronic myeloid leukemia chronic lymphoid leukemia multiple myeloma manifest myelofibrosis detected patients chronic myeloid leukemia without hematological response failure normalization hematological values patients progressing relapsing multiple myeloma combinations foci initial manifest myelofibrosis incident patients progressing relapsing chronic lymphoid leukemia incidence myelofibrosis higher patients multiple myeloma chronic lymphoid leukemia progression relapses patients chronic myeloid leukemia without hematological response disease debut case response chemotherapy response chemotherapy patients chronic myeloid leukemia chronic lymphoid leukemia associated decrease incidence myelofibrosis patients multiple myeloma responding chemotherapy incidence myelofibrosis change comparison disease debut
south african hiv aids epidemic enters fourth decade universal access treatment begun extend lives people living hiv aids south africa ruling party african national congress seized improved health bolster political profile key agitators producing outcome south african hiv aids activists narrative accounts extended initiative focused organisations led campaign treatment access treatment access campaign reflecting present trends social movement theory emphasis accounts transnational horizontal ties alliance building approach obscures continuities early south african hiv aids activism late apartheid era concept verticality proposed means highlighting role interpersonal relationships development institutions transmission knowledge practices link waves south african hiv aids activism
paper presents design procedure tangentially magnetized variable flux machines aims reduce machine inverter rating proposed design achieve high torque density low speeds high efficiency extended speed range armature axis current pulses applied high speeds reduce magnet flux thus avoiding flux weakening current conventional permanent magnet synchronous pmsms machines order regain full torque capability motor slows magnetizing current pulse applied amplitude magnetizing current usually larger machine rated current therefore machine might need oversized inverter order able magnetize magnets impact different machine design parameters magnetization current requirement investigated order reduce inverter cost
introduction analgesics commonly prescribed medications used alleviate pain various aetiologies without affecting patient consciousness interfere transmission pain signals commonly used antiepileptic drug sodium valproate used various non epileptic conditions like migraine prophylaxis treatment bipolar disorder multiple mechanisms acts docosahexanoic acid dha omega fatty acid known possess analgesic activity planned study assess effect sodium valproate alone combination dha rat models pain aim evaluate analgesic activity sodium valproate dha supplementation using various experimental models albino wistar rats materials methods analgesic activity total adult wistar albino rats divided eight groups six rats group control distil water group received intraperitoneal injection tramadol group iii injected intraperitoneal sodium valproate distil water respectively group vii viii given sodium valproate plus dha intraperitoneal respectively analgesic activity assessed using hot plate tail flick acetic acid writhing models results found sodium valproate higher doses used either alone along dha showed statistically significant analgesic activity comparison control various experimental models assessing pain conclusion combination sodium valproate along dha shown promising analgesic activity
nonlinear analysis framework bluff body aerodynamics based volterra theory introduced capture linear nonlinear aerodynamic effects volterra kernels based impulse function concept identified way simulation navier stokes equations using computational fluid dynamics cfd computational schemes used validated theoretical consideration blasius solution steady state theodorsen solution system dynamic state simulation source nonlinearities aerodynamics bluff bodies systematically investigated simulation bluff body aerodynamics based volterra reduced order modeling scheme obtained convolution identified kernels external inputs turbulent inflow body motion aerodynamic aeroelastic response respectively demonstrated volterra theory based nonlinear analysis framework bluff body aerodynamics combined identification kernels using cfd promises capture salient features bluff body aerodynamics offers accurate reduced order approximation navier stokes equations reduced level computational effort elsevier ltd rights reserved
aim paper investigate relationship self efficacy false memories using deese roediger mcdermott drm paradigm whereby people falsely remember words presented lists two studies participants presented drm lists asked recall recognize presented items first study found significant relationship memory self efficacy mse susceptibility associative memory illusions recall recognition also received memory self efficacy questionnaire mseq big five questionnaire bfq backward digit span bds test second study mse manipulated order assess whether changes influenced sensitivity parameter drm tasks results showed manipulation effective decreasing self efficacy turn affected probability reporting critical lures well sensitivity possible explanations effect discussed elsevier inc rights reserved
paper reviews sixty nine field failures involving geotextile filters performed unsatisfgctorily categorized herein failures grouped four categories inadequate design atypical soils unusual permeants improper installation first category poor fabric selection poor fabric design socked drainage pipe reversing flow conditions second category fine grained soils gap graded soils dispersive clays ochre third category sludges turbid water alkaline water leachates agricultural waste liquids fourth category lack intimate contact completely adhesive clogging surfaces topic paper noted conditions known troublesome sand filters well geotextile filters elsevier ltd rights reserved
purpose case study describe three dimensional biomechanics common ballet exercises ballet dancer ischial tuberosity apophysitis achieved comparing kinematics symptomatic ischial apophyseal symptoms contralateral lower limbs well via reported pain results suggest consistent differences movement patterns dancer differences included decreased external rotation contralateral hip hence decreased hip contribution turn increased contralateral knee adduction internal rotation apparent synchronicity contralateral lower limb decreased hip external rotation increased knee adduction minimal use ankle plantar dorsiflexion movement symptomatic side pain related left ischial apophysitis associated reduced amplitudes especially fast ballet movements required large range motion flexion adduction left hip joint findings suggest ischial apophysitis may limit dancer ballet technique performance
family planning methods act administered fertilisation would substantial benefits could used longer sex current emergency contraceptives potentially woman could use relatively rare occasions menstrual period delayed although methods would displease abortion opponents would likely welcomed many women research develop post fertilisation fertility control agents pursued
traditionally coarse fine mechanical stages within dual stage positioning system designed separately without consideration control performance dual stage integration paper flexurebased lorentz motor fine stage designed concurrently simple pid controller perform dual stage positioning based existing coarse stage design fine stage carried using proposed integrated servo mechanical design approach various specifications considered formulated constraints optimization problem approach plant modal parameters controller parameters fine stage concurrently solved demonstrates suitable mechanical plant design fine stage fulfill various control specifications using simple pid controller compensate sensitivity peak maintain stability etc meanwhile proposed design approach also ensures certain open loop positioning performance decoupling property coarse fine stages prototype designed fine stage fabricated experimental investigation indicates sensitivity peak effectively reduced coarse stage dualstage system fine stage able achieve submicrometer accuracy maximal tracking error also reduced significantly via coarse stage less dual stage positioning
last earthquake occurred chlef asnam algeria significant decrease shear strength caused major damages several civil hydraulic structures earth dams embankments bridges slopes buildings especially saturated sandy soil areas near chlef valley paper presents laboratory study drained compression triaxial tests conducted sandy soil reinforced horizontal layers geotextile order study influence geotextile layer characteristics shear stress strain volumetric change strain tests carried medium dense sand experimental programme includes drained compression tests performed reinforced sand samples different values geotextile layers number confining pressure relative density test results shown contribution geotextile low values axial strain epsilon negligible higher values epsilon geotextile induces quasi linear increase deviator stress leads increase volume contractiveness within reinforced samples negligible influence geotextile layers number stress strain behaviour volumetric change shown normalized results indicate contribution geotextile stress strain mobilization increases increasing confining pressure contribution volume contraction decreases increase confining pressure
sentiment analysis active research area today era due abundance opinionated data present online social networks semantic detection sub category sentiment analysis deals identification sentiment orientation text many sentiment applications rely lexicons supply features model various machine learning algorithms sentiment lexicons proposed research order improve sentiment categorization supervised machine learning algorithms domain specific sentiment lexicons generally perform better compared unsupervised semi supervised domain independent lexicon based approaches core hindrance application supervised algorithms domain specific sentiment lexicons unavailability sentiment labeled training datasets every domain hand performance algorithms based general purpose sentiment lexicons needs improvement research focused building general purpose sentiment lexicon semi supervised manner proposed lexicon defines word semantics based expected likelihood estimate smoothed odds ratio incorporated supervised machine learning based model selection approach comprehensive performance comparison verifies superiority proposed approach
primary myelofibrosis aggressive classic philadelphia chromosome negative myeloproliferative neoplasms mpns clonal disorder characterized often debilitating constitutional symptoms splenomegaly bone marrow fibrosis resultant cytopenias extramedullary hematopoiesis risk leukemic transformation shortened survival post polycythemia vera post essential thrombocythemia myelofibrosis represent similar entities although differences recognized attempts classify patients myelofibrosis prognostic categories made since late scoring systems continue evolve new information becomes available last decade molecular pathogenesis mpns elucidated considerably janus kinase jak inhibitor ruxolitinib first drug specifically approved food drug administration treat patients intermediate risk high risk myelofibrosis article reviews evolution prognostic criteria myelofibrosis emphasizing major systems widely use today well recently described novel systems incorporate emerging data regarding somatic mutations risk factors thrombosis conversion mpn blast phase also discussed finally practical usefulness current prognostic classification systems terms clinical decision making discussed particularly within context inherent weaknesses american cancer society
background objective study evaluate incidence non aids defining malignancies nadms among people living hiv aids plwha british columbia focusing clinical correlates highly active antiretroviral therapy haart use survival order elucidate mechanisms nadm development methods retrospective population based analysis carried individuals hiv aids began treatment results nadms aids defining malignancies adms identified plwha study population nadms represented range cancer types including commonly lung cancer followed anal breast head neck prostate liver rectal renal cancers plwha sir development nadms compared individuals without hiv aids diagnosis general population independent factors significantly associated nadm male gender older age lower cell counts previous nadm absence haart non haart versus haart treatment early haart era versus conclusions nadms represent important source morbidity plwha use haart associated improvement immune restoration tailored targeted cancer screening interventions may beneficial improve outcomes unique patient population
information hiding active area research secret information embedded innocent looking carriers images videos hiding existence maintaining visual quality researchers presented various image steganographic techniques since last decade focusing payload image quality however trade two metrics keeping better balance still challenging issue addition existing methods fail achieve better security due direct embedding secret data inside images without encryption consideration making data extraction relatively easy adversaries therefore work propose secure image steganographic framework based stego key directed adaptive least significant bit ska lsb substitution method multi level cryptography proposed scheme stego key encrypted using two level encryption algorithm tlea secret data encrypted using multi level encryption algorithm mlea encrypted information embedded host image using adaptive lsb substitution method depending secret key red channel mlea sensitive contents quantitative qualitative experimental results indicate proposed framework maintains better balance image quality security achieving reasonable payload relatively less computational complexity confirms effectiveness compared state art techniques
universal multi input single output type multifunction biquad proposed proposed configuration employs one current differencing transconductance amplifier active element two capacitors three resistors circuit realizes five filter functions low pass high pass band pass notch pass without changing circuit topology natural frequency omega independently electronically tunable workability proposed multifunction biquad verified using spice simulation
article presents methodology optimal distributed generation allocation sizing distribution systems order minimize electrical network losses keep acceptable voltage profiles optimization problem considered equality inequality constrains hours power load levels operational voltage limits conventional power flow placement binary variables sizing active reactive power optimization problem solved mixed integer nonlinear programming minpl using knitro solver
coming media era changed way traditional media information dissemination decreased limitation terrain time make easier media violence come spread paper explores spreading characteristics strong weak points future development tendency end proposes related measures protection strategies deal
measuring post fire effects landscape scales critical ecological understanding wildfire effects predominantly accomplished either multi spectral remote sensing data ground based field sampling plots methods important field data usually limited opportunistic post fire observations spectral data often lacks validation specific variables change additional uncertainty remains regarding best account environmental variables influencing fire effects weather observational data easily acquired whether pre fire agents change bark beetle timber harvest impact model accuracy study quantifies wildfire effects correlating changes forest structure derived multi temporal light detection ranging lidar acquisitions multi temporal spectral changes captured landsat thematic mapper operational land imager pole creek fire central oregon spatial regression modeling assessed methodology account spatial autocorrelation model consistency quantified across areas impacted pre fire mountain pine beetle timber harvest strongest relationship pseudo observed ratio shortwave infrared near infrared reflectance lidar derived estimate canopy cover change relationships percentage lidar returns forest strata spectral indices generally increased strength strata height structural measurements made closer ground well correlated spatial regression approach improved relationships demonstrating utility model performance declined across pre fire agents change suggesting studies stratify pre fire forest condition study establishes spectral indices dnbr sensitive wildfire caused structural changes reduction canopy cover perform best structure reduced pre fire elsevier inc rights reserved
recently many studies shown potential use circulating exosomes novel biomarkers monitoring predicting number complex diseases including cancer however reliable cost effective detection exosomes routine clinical settings still remain difficult task mainly due lack adequately easy fast assay platforms therefore demonstrate development visible simple method detection exosomes integrating single walled carbon nanotubes excellent water solubility swcnts aptamer aptamers specific exosomes transmembrane protein absorbed onto surface swcnts improve minic peroxidase activity swcnt efficiently catalyze mediated oxidation tetramethylbenzidine tmb lead change colorless blue solution however adding exosomes aptamers bound leaving surface swcnts conformational changes results color solution deep moderate observed naked eye monitored vis spectrometry optimal conditions linear range exosomes estimated particles detection limit lod particles consequently visible simple approach detecting exosomes successfully constructed moreover proposed colorimetric aptasensor universally applicable detection targets simple change aptamer
paper parallel structure fractional repetitive control scheme proposed improve performance pulsewidth modulation pwm inverters fractional cases sampling rate digital control system integral multiple fundamental frequency introducing correction factor new control scheme increases control gains harmonics locates poles accurately targeted harmonic frequencies result proposed control scheme achieves better tracking rejection performance conventional moreover parallel structure fractional repetitive controller requires less data memory dynamic response also improved stability convergence method proved experimental results single phase pwm inverter illustrate advantages control scheme
background idiopathic intracranial hypertension iih syndrome defined elevated intracranial hypertension without radiographic evidence mass lesion brain dural venous sinus stenosis increasingly recognized treatable cause dural venous sinus stenting dvss increasingly performed methods year single center retrospective analysis consecutive patients undergoing dvss medically refractory iih results patients mean imaging follow months mean clinical follow period months dvss performed first procedure medically refractory iih patients whereas patients included previously surgical procedure ventriculoperitoneal shunt optic nerve sheath fenestration onsf headache present patients dvss improved remained stable respectively visual acuity changes visual field changes present patients respectively visual field improved remained unchanged worsened stenting stent patency rate stenosis rate procedures performed technical success rate zero major minor complications conclusion based single center retrospective analysis dvss performed high technical success low complication rates majority patients presented primarily headache patients excellent symptom relief dvss alone patients presenting visual symptoms lower success rates population stented carefully followed progression symptoms
motion thin viscous film fluid curved surface exhibits many intricate visual phenomena challenging simulate using existing techniques possible alternative use reduced model involving temporal evolution mass density film surface however model motion governed fourth order nonlinear pde involves geometric quantities curvature underlying surface therefore difficult discretize inspired recent variational formulation problem smooth surfaces present corresponding model triangle meshes provide discretization curvature advection operators leads efficient stable numerical scheme requires single sparse linear solve per time step exactly preserves total volume fluid validate method qualitatively comparing known results literature demonstrate various intricate effects achievable method droplet formation evaporation droplets interaction viscous fingering finally extend method incorporate non linear van der waals forcing terms stabilize motion film allow additional effects pearling
worldwide many nonsmokers often women children exposed second hand smoke shs home settings men retain traditional power control within family women children limited agency intervene study set explore home smoking management rural china found women able positively intervene restrict men smoking three key stages prior conception pregnancy early years children lives utilizing dominant social health political narratives importance raising healthy child supported one child policy china combined fear health risks shs young children women able use elevated status bearer carers children subvert pre eminence men domestic environments enabling positively influence home smoking study highlights possibility future smoking cessation initiatives china incorporating family carers elevated awareness protection children health key stages childhood also need health education family members unsure needed keep children smoke free may partially explain households smoke free
objective cognitive behavioral models postulate selective attention plays important role maintenance body dysmorphic disorder bdd suggested individuals bdd overfocus perceived defects appearance may contribute excessive preoccupation appearance methods present study used eye tracking examine visual selective attention individuals bdd compared individuals bulimia nervosa healthy controls hcs participants completed interviews questionnaires rating scales eye tracking task eye movements recorded participants viewed photographs face attractive well unattractive faces results eye tracking data showed bdd participants focused less self rated attractive facial part hcs scanning patterns faces showed bdd participants paid much attention attractive unattractive features face whereas focused attractive features attractive faces hcs paid attention attractive features face attractive faces conclusion results indicate attentional bias bdd participants manifesting neglect positive features compared hcs perceptual retraining may important aspect focus therapy order overcome neglect positive facial aspects future research aim disentangle attentional processes bdd examining time course attentional processing elsevier inc rights reserved
study contribution analysis energy production hybrid systems using renewable energy sources realized within framework isolated site without connection electrical network generally conventional solutions energy production needs terms electrical energy thermal energy met separately paper explore alternative approach based strategy hybridization uses energy conversion meet energy needs alternative approach large part directly produced thermal energy replaced electrical energy air water heat pump variable input power introduced ensure crossover thermal energy flow electrical energy flow contributions work summarized follows firstly propose methodology control functioning air water heat pump variable input power secondly compare potential thermal energy production two subsystems show interest using energy conversion according type climate thirdly present case study precisely study realized representative locations france objective twofold first analysis energy potential representative sites given second established energy produced increased using hybridization strategy based energy conversion especially winter critical period terms electrical thermal needs simulation experimental results presented analyzed show interest introducing pump heat hybrid system mainly using technology variable input power elsevier ltd rights reserved
one eight foods account food allergies wheat must excluded diet patients suffering wheat allergies studies wheat dependent exercise induced anaphylaxis wdeia used model develop hypoallergenic wheat know gluten fraction wheat protein particularly omega gliadin high molecular weight hmw glutenin responsible allergic response however studies allergic responses wdeia performed single wheat cultivar thus effort provide information development hypoallergenic wheat compared various cultivars different countries origin characteristics first step compared allergen contents omega gliadin hmw glutenin cultivar allergic response caused cultivar domestic wheat cultivars lower contents omega gliadin hmw glutenin imported wheat cultivars additionally cultivars caused varying allergic responses due allergen components regression analysis allergen contents allergic responses vivo suggest prediction model estimate extent allergic response based omega gliadin hmw glutenin contents studies needed analyze biological interactions allergens various cultivars allergic response factors
objective study aimed assess usefulness narrow band uvb uvb therapy yemeni patients different skin conditions methods prospective clinical audit conducted yemeni patients males females aged years patients different skin diseases dermatology clinic january may treated uvb irradiation without combined topical steroid topical chemotherapy course study results patients enrolled study mean age years old females consisted major rate patients came aden high rate ninety four patients complete response treatment partial response mycosis fungoid atopic dermatitis high mean number session followed vitiligo mean number sessions lichen planus mycosis pityriasis complete response treatment followed vitiligo partial response appeared patients alopecia atopic dermatitis patients chronic renal failure response treatment followed parapsoriasis conclusion study proves uvb therapy effective safe tool management skin diseases considered first line phototherapeutic option many skin conditions
background borderline personality disorder bpd complex clinical state highly polymorphic symptoms signs studies demonstrated people bpd diagnosis likely numerous occurring psychiatric disorders physical comorbidities aim study obtain insight associations among comorbidities bpd demonstrate practicality using association rule mining arm technique clinical databases methods retrospective case control study conducted information patients bpd patients control patients selected taiwan national health insurance research database information physical psychiatric comorbidities diagnosed within years enrollment collected logistic regression model used calculate odds ratios comorbidities patients without bpd arm technique used study associations bpd two psychiatric comorbidities results classified physical comorbidities categories according international classification diseases ninth revision clinical modification system results indicated categories common bpd patients control patients except congenital anomalies however psychiatric comorbidities including depressive disorder bipolar disorder anxiety disorder sleep disorder substance use disorder mental retardation common bpd patients control patients furthermore associations bpd two comorbidities evaluated conclusion physical psychiatric disorders common bpd patients control patients failure remit bpd associated suffering chronic physical conditions psychiatric comorbidities may lead delays diagnosis bpd clinicians caring people bpd aware possible comorbidities
goal study explore associations among maternal agreeableness child temperament emotion dysregulation children social adjustment school participants children kindergarten grade girls age months months mothers provided ratings agreeableness child temperament teachers assessed indices children socioemotional functioning school among results maternal agreeableness moderated associations child dysregulation aspects adjustment school specifically higher levels maternal agreeableness relations child dysregulation anxiety peers prosocial behavior attenuated overall results suggest maternal agreeableness may serve protective factor dysregulated children implications research practice discussed
branch complex system spans wide range areas physical technological systems social biological systems first step complex system analysis modeling important task scientific studies field theory practice complex system modeling considered recent years well known system identification theory methods establishing mathematical models complex systems consequently identification approach class complex nonlinear system put forward paper idea identification method employs system model composed classical models transform system structure identification problem combinatorial optimization problem initially artificial fish swarm optimization algorithm used synchronously implement identification system structure parameters finally simulation compared algorithm simulation results show proposed scheme feasible
nowadays important study provide confidentiality digital image encryption proposals committed inquire visual secret sharing vss techniques traditional scheme mainly focused binary images later investigations extended grayscale color images visual cryptography encodes secret information shares distribute among group participants qualified participants reconstruct original image superimposing collected share images regrettably previous schemes still weakness construction secret shares reconstruction secret image paper present reversible visual cryptography technique color images using galois field theory secret image split two sub images shared cover image construct stego images additionally galois field theory applied construct brother stego images effective transmission individual stego brother stego images reveal nothing galois field inverse operation exponential employed reveal secret image pair pixels brother stego images reveals cover images
event sequences estimation important issue fault diagnosis discrete event systems far fault events directly measured paper event sequences estimation petri net models events assumed represented transitions firing sequences estimated measurements marking variation estimation without measurement errors discussed dimensional vector space alphabet sufficient conditions estimation algorithms provided performance evaluated efficiency approach illustrated two examples manufacturing engineering
aim development new multi level model fuzzy semi structured information data storage distinction proposed model known use extended polybasic intuitionistic sets description fuzzy data representation fuzzy attributes three typing levels main result formal description fuzzy semi structured data storage verify result example application developed model data storage intellectual diagnostic decision making system railway transport showed
wireless networks gained immense popularity recent years though wireless networks innumerous advantages conventional wired networks borderless nature wireless networks makes prone various felonious activities context network security one crucial vulnerabilities caused serious global concern mac address spoofing mac address spoofing facilitates launching attacks denial service man middle syn flooding etc paper propose methodology detection spoofing attacks ieee networks involve performance cluster analysis rss patterns transmitters detect presence spoofing attack also determine number attackers localizing adversaries propose discriminant adaptive neural network dann based localization system
purpose purpose paper present coordinate measuring system possibilities meaning geometric accuracy assessment hot zone elements aircraft engines aim paper prove method uses blue light sufficient cost saving method used production line serial manufacturing elements high level accuracy required design methodology approach analysis geometric accuracy blades performed using non contact optical coordinate scanner atos triple scan blue light manufactured gom company department mechanical engineering rzeszow university technology geometric analysis conducted blades manufactured different waxes afr realwax visijet cpx thus comparing injection technique rapid prototyping method casting made inconel nickel based superalloy findings analysis criteria method blades measuring selection showed chosen system successfully met criteria verification blades geometry selected stages process atos optical scanner blue light technology allows measurement almost regardless daylight artificial white light allows application measurement system production cycle thus eliminating need create special conditions measurements practical implications requirements related accuracy measured values diversity allowable measurement time linked methods production modern manufacturing methods based computer aided design systems manufacturing engineering systems require non contact optical measurement method based computer aided based coordinate measuring technique case non contact optical scanning method based atos gom measuring system time measurement costs depend methodology measurement possibility automation presented paper practical impact possibilities automation geometric accuracy measurements obtained elements series production line social implications use atos triple scan blue light gom company allows reduction cost time production possibility introduction system automated production line additionally measurement hot section blades aircraft engines using blue light method much accurate implication impacts safety used manufactured elements originality value paper presents possibility using atos triple scan blue light measuring system geometric accuracy measurements case hot section blades aircraft engines research original describes three model geometric accuracy measurements wax model obtained using injection technique wax model obtained using process casting made inconel nickel based superalloy
primary goal current study test whether parent adolescent preference common language moderates association parenting rank order change time offspring substance use sample mexican origin grade adolescents age years female measured longitudinally use tobacco alcohol marijuana mothers fathers adolescents reported consistent discipline monitoring adolescents consistent discipline monitoring predicted relative decreases substance use early adulthood among parent offspring dyads expressed preference language either english spanish moderation held controlling parent substance use family structure completed schooling mexico years lived united states family income cultural values unintended consequence immigration process may loss parenting effectiveness normally present parents adolescents prefer communicate common language
researchers assume employees personality characteristics affect leniency rating others however little research investigated two tendencies time present study developed one index rating leniency another one self rating leniency based review literature hypothesized generous assessment peers would likely made extroverted agreeable furthermore generous assessment oneself would likely made people conscientious emotionally stable people also investigated leniency rating others leniency rating oneself part general leniency tendency data collected sample real estate dealers provided support hypotheses limitations implications future research discussed
cutting strength proposed new indicator resistance materials cutting indicator ratio cutting force orthogonal cutting cross section part specimen cut essentially depends property material independent cutting width depth also give indication resistance surfaces scratching elsevier rights reserved
paper describes experiments relating buffet response control section long span suspension bridge deck elastically mounted part wind tunnel experiment bridge section subject grid generated flow turbulence two grids used one standard biplanar grid second new design provides larger turbulence length scales buffet response results compared admittances calculated using unsteady three dimensional lifting surface theory extends standard two dimensional sears theory bridge deck heave pitch responses predicted comparisons made wind tunnel measurements order suppress buffeting increase deck critical flutter speed deck model fitted controllable leading trailing edge flaps two sets passive controllers use flap angles control inputs demonstrated evaluated capability suppress buffet response deck increase critical flutter speed first set controllers sense deck position pitch angle heave pitch angle alone whilst second set mechanical controllers sense vertical velocity flap hinge points control system design problem solved mixed infinity optimisation problem wind tunnel experiments show control systems reduce considerably deck buffet response whilst simultaneously increasing critical flutter speed elsevier ltd rights reserved
relationship among beta glucans galactomannan risk developing invasive fungal infections ifi observed adult icu children hematological malignancies scant data evaluated value assays diagnosis ifi patients nonhema tological diseases pediatric intensive care unit picu study assessed diagnostic value markers ifi picu records patients retrospectively evaluated patients proven probable cases without evidence ifi performed assays results showed many factors associated false positive test results patients aged years higher levels younger infants levels higher subjects dairy human blood products antibiotics corticosteroids therapy cases without treatments unlike assay assay less susceptible mentioned factors expect blood products levels ifi cases dramatically higher controls diagnostic performance assays showed assay better results compared assay whole negative predictive value assays dramatically higher diagnostic parameters conclusion assay highly susceptible many factors assay could useful diagnosis ifi high sensitivity benefit assay limited inadequate specificity comparative advantage assays lied excluding ifi non hematological picu patients
commentary reviews league film provides fictional account lives women played first year american girls baseball league set world war era america film offers look gendered lives women seeking careers traditionally masculine fields authors review movie feminist media lens specific emphasis two main characters dottie kit ascribe defy gender stereotypes gain voice agency specific implications pulled analysis used context counseling women including empowerment female clients establishing career identity
persistent hepatitis virus hcv infection associated progressive hepatic fibrosis ultimately hepatocellular carcinoma interleukin ilb polymorphism associated fibrosis progression chronic hcv infection ilb encodes interferon lambda antiviral anti proliferative properties study aimed determine whether ilb polymorphism also associated development hepatocellular carcinoma chronic hcv infection non viral related cirrhosis real time polymerase chain reaction melting curve analyses used genotype patients underwent liver transplantation hcv cirrhosis alcoholic cirrhosis hcv patients older less likely males patients alcoholic cirrhosis ilb genotype allele carriage frequent among hcv patients among common patients infected hcv genotype incidence hepatocellular carcinoma higher hcv cirrhosis differences according hcv genotype ilb genotype distribution similar among patients without hepatocellular carcinoma hcv patients regardless viral genotype alcoholic patients multivariate analysis showed older age male gender independent risk factors hepatocellular carcinoma hcv patients summary current study find significant association ilb polymorphism hepatocarcinogenesis
increasing number wind turbines erected offshore need cost effective predictive proactive maintenance large fraction wind turbine downtime due bearing failures particularly generator gearbox one way assessing impending problems install vibration sensors key positions subassemblies equipment costly requires sophisticated software analysis data alternative approach require extra sensors investigated paper involves monitoring power output variable speed wind turbine generator processing data using wavelet order extract strength particular frequency components characteristic faults done doubly fed induction generators dfigs commonly used modern variable speed wind turbines technique first validated test rig controlled fault conditions applied two operational wind turbine dfigs generator shaft misalignment detected one turbines technique detected problem months bearing failure recorded
output modal identification seen significant activity recent years especially large scale structures controlled input force generation often difficult achieve led development new system identification methods require controlled input often work satisfactorily satisfy general assumptions overly restrictive regarding stochasticity input hundreds papers covering wide range applications appear every year related extraction modal properties output measurement data two dozen mechanical aerospace civil engineering journals little decade concepts blind source separation bss field acoustic signal processing adopted several researchers shown attractive tools undertake output modal identification originally intended separate distinct audio sources mixture recordings mathematical equivalence problems linear structural dynamics since firmly established enabled many developments field bss modified applied output modal identification problems paper reviews hundred articles related application bss variants output modal identification main contribution paper present literature review papers appeared subject brief treatment basic ideas presented relevant comprehensive critical explanation contents attempted specific issues related output modal identification relative advantages limitations bss methods theoretical application standpoints discussed gap areas requiring additional work also summarized paper concludes possible future trends area elsevier ltd rights reserved
paper introduces new basic concepts electrical circuits theory minimum dissipated power defined demonstrated general principle electrical circuits stationary quasi stationary regime based matrix formulation principles nodal method analysis obtained number examples presented prove originality main novel concepts
transcription factor related factor nrf key regulator cellular defense mechanisms oxidative stress multiple sclerosis chronic inflammatory disease central nervous system characterized progressive demyelination neurodegeneration induced inflammation oxidative stress induction nrf signaling shown inhibit disease development progression experimental autoimmune encephalomyelitis eae model mice present study performed high throughput screening assay using chimeric construct terminal portion nrf fused lacz using approach identified novel nrf inducer tfm using human primary cell profiling systems found tfm inhibited cell proliferation exerted immuno modulatory effects inhibiting production tfm also inhibited secretion human peripheral blood mononuclear cells stimulated anti anti eae mice treated tfm expression nrf target gene nqol increased brain spleen disease severity ameliorated plasma levels decreased furthermore tfm inhibited luciferase activity wim transgenic eae mice expressing human interleukin luciferase hfl bac luc reporter therefore findings indicate tfm potent nrf inducer inhibits inflammatory cytokine production disease progression mice eae tfm promising therapeutic agent
major simplifications corresponding rigorous thermal thermo mechanical analyses applied chapter transient temperature fields replaced fixed temperature profiles computationally efficient methods introduce simplifications transverse longitudinal thermal strains derived approximations embodied mismatched thermal strain transverse contraction strain algorithms analytical approach strains applied linear elastic small strain models using conventional strength materials techniques computational approach strains applied linear elastic large strain finite element models various hybrid stepwise methods also shown measure sequential description included together use elasto plastic finite element computation
paper introduces novel methodology automated detection buildings single high resolution optical images visible red green blue bands data particular first investigate shadowevidence focus building regions novel markov random field mrf based region growing segmentation technique proposed image oversegmented smaller homogeneous regions used replace rigid structure pixel grid iterative classification merging applied set regions iteration regions classified using region level mrf model according position shadows regions class merged produce new regions whose shapes appropriate rectangles final buildings determined using recursive minimum bounding rectangle experimental results prove proposedmethod applicable various areas high dense urban suburban rural highly robust reliable
many datastore systems choose differ many ways including public versus private cloud support data management interfaces programming languages supported feature sets fault tolerance consistency guarantees configuration deployment processes paper focus technologies structured data access database datastore systems cloud systems goal simplify use datastore systems automation facilitate empirical evaluation using real world applications enable provide cloud platform abstraction layer decouples data access api implementation applications use api use datastore plugs abstraction layer thus enabling application portability use layer extend functionality multiple datastores without modifying datastores directly specifically provide support acid transaction semantics popular key value stores none provide feature integrate layer appscale cloud platform open source cloud platform executes cloud applications written python java virtualized cluster resources infrastructures service eucalyptus openstack amazon use system investigate impact extending disparate datastores via application portability layer distributed transaction support
accessible summary known subject caregivers adolescents adhd experience major difficulties care providers need guidance support adolescents adhd may develop oppositional criminal behaviour symptoms adulthood one fourth severe emotional antisocial difficulties lack evidence caregivers supporting intervention although caregiver groups found contribute better coping decreased stress improvements adhd symptoms paper add existing knowledge primary caregivers adolescents adhd experienced better quality life therapeutic conversation intervention intervention contributed better social functioning among secondary caregivers implications practice content therapeutic conversation intervention significant highlights utility combination group private sessions caregivers people adhd intervention influence services families organized therapeutic conversation intervention could offered regular basis abstract introduction caregivers adolescents attention deficit hyperactivity disorder burdened tasks many suffer distress adolescents adhd may develop antisocial behaviour caregivers group empower caregiver supporting role aim question evaluate effectiveness therapeutic conversation intervention caregivers adolescents adhd regarding strengthening supportive role method study utilized quasi experimental design participants caregivers adolescents years old adhd intervention consisted group parent sessions calgary family model family illness beliefs model used theoretical frameworks results study revealed significant differences improvement quality life regarding primary caregiver worry daily activities family relationships collaboration post intervention well emotional functioning post intervention follow secondary caregiver social functioning significantly improved follow discussion intervention proved beneficial caregivers filling gap much needed intervention implication practice results expand health care professionals knowledge increase quality life supporting adolescent adhd treatment information improve service health care centres hospitals adolescents adhd receive care
skin fortified setup lipophilic hydrophilic enzymatic non enzymatic antioxidant systems ascorbyl palmitate sodium ascorbyl phosphate sap reported lipophilic hydrophilic antioxidants respectively used skin care present study aimed assess combined oil phase sap aqueous phase via multiple emulsion controlling sebum secretions healthy human females ftir analysis sap performed identification multiple emulsions control prepared analyzed physical stability antioxidant activities sap well combination compounds determined dpph method female volunteers included single blinded placebo controlled split face comparative study volunteers instructed apply left cheek control without sap right cheek period days non invasive photometric device sebumeter used measurement sebum secretions sides face subsequent time intervals good antioxidant activity observed treatments reduced significant facial sebum secretions compared control placebo treatments concluded combined sap supplementations skin proved promising choice controlling facial sebum secretions could evaluated undesired oily skin acne reductions beautifying facial appearance
modeling microring resonator modulators phase rings presented phase ring effect bandwidth optimization studied using proposed model results show phase ring enhance modulation effectively also causes modulation resonances worsens modulation performances resonators double phase rings keep coupling region symmetric good phase enhancement ability amplitude modulated signal increased substantially phase rings optimized setting operating point resonance point
paper describes innovative fiber reinforcement technology cementitious composite structures employs situ shrinking microfibers provide supplemental strength enhancing compressive stresses reinforced concrete one commonly used structural materials construction industry primarily due cost durability ability easily fabricated variety shapes site locally abundant raw material availability almost everywhere unlike incumbent passive reinforcing microfiber technology situ shrinking microfibers respond situ stimulus heat moisture variations induce precompression matrix create additional resistance external loads creating stronger composite structures paper heat activated shrinking microfibers made polyolefin activated shrinking phas microfibers made chitosan powder used study effects shrinking microfiber reinforcing concrete shrinking ratios tensile strengths microfibers measured cementitious specimens active shrinking microfibers passive non shrinking fibers well control samples made mechanical properties samples compared compression three point bending tests optimum microfiber weight percentages microfibers compression tests three point bending tests phas microfibers optimum weight percentages three point bending tests compared heat passive microfibers specimens increase maximum compression strengths increase maximum bending strengths achieved optimum weight percentages microfibers addition phas microfibers increase maximum bending strengths three point bending tests resulted compared passive microfibers specimens
using recycled concrete crumb rubber aggregates produce green concrete promising technology toward sustainability construction industry study compressive flexural behaviours new type concrete material rubber crumb steel fibre reinforced recycled aggregate concrete rsrac investigated popularise application new type green building material experimental study conducted investigate effect rubber content compressive flexural behaviours rsrac total cubes cylinders tested axial compressive loading prisms tested subjected three point bending crumb rubber content varied investigation levels volume substitution sand recycled concrete aggregate rca introduced concrete mixture volume substitution natural coarse aggregate nca volumetric quantity steel fibre added concrete mixture effect rubber content compressive flexural strength failure mode modulus elasticity toughness rsrac analysed results indicate rsrac optimal rubber content displays good compressive behaviour compared normal nca concrete rsrac also environmentally friendly alternative normal rubber concrete use flexural members concrete structures elsevier ltd rights reserved
current study assigned evaluate total phenol total flavonoid content tpc tfc antioxidant properties extracts aerial parts scrophularia frigida frigida extracts also tested preliminary phytochemical screening well cytotoxic activity artemia salina mcf human breast carcinoma colon carcinoma normal cell lines along antimicrobial characteristic dpph mtt brine shrimp lethality tests disc diffusion method carried determine biological activities different extracts frigida addition extracts potent antioxidant antiproliferative activity analyzed nmr methanol water meoh extract fraction showed higher amounts tpc tfc antioxidant property findings study general toxicity effect showed dichloromethane dcm meoh extracts weak moderate effects furthermore dcm extract indicated potent anti proliferative activity cancer cell lines evidence antibacterial activity determined hand analysis potent extract dcm cytotoxic assay showed presence trans phytol cis oleic acid gcms furthermore nmr analysis potent methanolic fractions antioxidant tests revealed presence iridoids phenolics generally results tpc tfc antioxidant activity extracts fractions agreement
background osteoid osteoma common benign bone tumour rarely found talus nidus difficult detect early imaging atypical symptoms presence concurrent trauma sports injuries may lead misdiagnosis delayed treatment herein analyse case misdiagnosis talus discuss improve early diagnosis rare lesion thereby permitting rapid treatment case presentation year old man history left ankle sprains chronic pain diagnosed another ankle sprain managed conservatively based normal ray findings year recurring pain diagnosed ankle traumatic arthritis underwent arthroscopic surgery preoperative ankle ray findings still normal magnetic resonance imaging time demonstrated bone marrow oedema left talus symptoms reappeared shortly surgery progressively worsened magnetic resonance imaging performed months surgery demonstrated widespread bone marrow oedema talus patient presented hospital pain assessment diagnosed talus years symptoms began preoperative computed tomography demonstrated typical nidus talus second surgery patient symptoms completely resolved pathologic examination confirmed lesion patient recovered months later able walk normally conclusions ankle joint exhibits progressive course difficult diagnose early stage patients talus often atypical imaging findings signs ankle instability anterior talofibular ligament tenderness valuable diagnosing although multiple scans may required detect nidus proper imaging helps doctors achieve correct diagnosis early disease course significantly shortening treatment cycle improving patient quality life
infection serious complication implantation total knee prostheses however fungal infection rarely found periprosthetic joints reports infecting organism candida species case report infection left knee total arthroplasty caused malassezia species patient still undergoing antifungal therapy voriconazole still followed authors knowledge present case first report malassezia species patient total knee arthroplasty
present study results measurement campaign aiming assess cancer risk among two special groups population policemen laboratory technicians exposed toxic substances benzene formaldehyde presented exposure compared general population risk results show policemen working outdoor traffic regulation patrol foot vehicles etc exposed significantly higher benzene concentration times general population exposure carbonyls general lower laboratory technicians appear highly exposed formaldehyde significant variation benzene exposure comparison general population recorded assessment revealed laboratory technicians policemen run higher cancer risk respectively compared general population indoor working place air quality significant assessing cancer risk two categories professionals due higher inhalation unit risk iur formaldehyde compared benzene since origin danger laboratory technicians clear use chemicals necessary experiments policemen presence carbonyls indoor air concentrations due smoking used materials constitute danger equal exposure traffic originated air pollutants
paper describes provider patient communication process although new health care general new pharmacy profession health coaching technique empowers patients make lasting health behavior changes improve overall well provides patients health care implementation options better suit lifestyle abilities health coaching programs potential foster better health outcomes especially patients chronically ill represent risk population medication non adherence elderly patients psychotropic medications health professions nursing medicine success implementation health coaching models example nurse coaching recognized american nurse association recent statistics show million nurses also trained nurse coaching pharmacy profession yet tap patient related benefits health coaching commentary discuss theoretical foundations health coaching distinctions health coaching motivational interviewing traditional medication therapy counseling iii training necessary health coaching pharmacists use health coaching practice elsevier inc rights reserved
pair programming two developers share computer work together developing one piece code test pair programming effects student performance middle eastern society interaction restrictions found devised experiment carried entire academic year consists two semesters experiment targeted two sections per semester advanced computer programming course students one sections worked pairs lab sessions applying pair programming rules techniques section students worked individually norm programming labs experiment revealed pair programming potential increase students confidence enjoyment course improved course completion rate addition students pair programming section showed able individually produce code better quality students traditional section
aiming evaluating see performance complex electronic system multi signal flow graph msfg method adopted based theory msfg see soft error propagation model proposed analysis methodology stated complex electronic system consists vlsis devices sram based fpga msfg model established simulated teams software fault diagnosis average first failure time estimated report indicates percentage fault detection average first failure time system varies hours days
background pea fiber potential fibrous supplement swine production influence dietary microbial community colon pigs remains largely unexplored methanogens hindgut monogastric animals play important roles degradation dietary fibers efficient removal microbial metabolic end product understanding impact dietary structure colonic methanogens may help understand mechanisms microbe mediated physiological functions study investigated influence diversity quantity activity colonic methanongens piglets finishing pigs four archaeal rrna clone libraries constructed piglets finishers fed control piglet finisher diet piglet finisher results clones obtained library piglet piglet finisher finisher respectively corresponding otus operational taxonomic units significant differences shannon index among four libraries found libshuff analysis showed archaeal community structure among four libraries significantly different predominant methanogens shifted methanobrevibacter methanobrevibacter methanomassiliicoccus like genus result dietary supplementation significantly increased copy numbers mcra dsra genes conclusions alteration methanogenic community structure may lead functional transition utilization employment methanol quantification three functional genes mcra dsra fhs methanogens sulfate reducing bacteria srb acetogens revealed dietary also increased activity methanogens srb probably associated increased proportion methanomassiliicoccus luminyensis species study required examine interaction specific methanogens srb fermentation dietary
flavonoids known trigger intrinsic genetic adaptive programs hypoxic oxidative stress via estrogen receptor engagement upstream kinase activation reveal specific structural requirements direct stabilization transcription factors responsible triggering antihypoxic antioxidant programs studied flavones isoflavones catechols including dihydroxybenzoate didox levodopa nordihydroguaiaretic acid ndga using novel luciferase based reporters specific first step hif nrf protein stabilization distinct structural requirements either transcription factor stabilization found expected requirements activation hif odd luc reporter correlate silico binding hif prolyl hydroxylase contrast stabilization nrf requires presence dihydroxy catechol groups thus flavonoids direct activators hypoxic antioxidant genetic programs ndga creosote bush resembles best flavonoids ability directly stabilize hif nrf superior respect lox inhibition thus favoring compound others given much higher bioavailability stability ndga flavonoid ndga tested methyl phenyl tetrahydropyridine mptp animal model parkinson disease demonstrated neuroprotective effects
hexagonal boron nitride ceramic compound thermally stable omicron air due challenging task etch air atmosphere low temperature study report flakes easily etched oxidation omicron air atmosphere presence transition metal oxide selecting elements precursors simply oxidized sheets impregnated precursors omicron air result microscopic analysis revealed etched structure created surface flakes regardless catalyst type ray diffraction patterns indicated air oxidation led formation coo cuo zno precursor thermogravimetric analysis showed gradual weight loss temperature range weight flakes increased air oxidation result etching pore volume pore area flakes increased catalytic oxidation cases addition surface flakes became highly active samples etched coo cuo catalysts based results report flakes easily oxidized presence catalyst resulting etched structure layered structure elsevier rights reserved
background one disadvantages zirconia implants lack elasticity increased use ceramic zirconia crowns consequences could result lack elasticity led search new materials improved mechanical properties case presentation patient year old woman non smoker medical record interest longitudinal fracture palatal root molar tooth absence tooth selected order receive zirconia implant peek based restoration composite coating following case report describes analyses treatment zirconia implants molars following flapless surgical technique zirconia implants alternative titanium implants patients allergies sensitive metal alloys however one disadvantages lack elasticity increases use ceramic zirconia crowns consequences arise lack elasticity led search new materials better mechanical properties cushion occlusal loads peek based restoration implant prosthetics compensate occlusal forces facilitating cushioning chewing conclusion procedure provides excellent elasticity resembles natural tooth structure clinical case suggests peek restorations used zirconia implants dentistry
purpose review registries useful discover applicability data generated randomized clinical trials rcts daily practice search real life data usually covered recent findings allergy registry research brought clues important epidemiological clinical problems hardly accessible methods increase asthma prevalence sweden contrast stabilization denmark association prevalence asthma environmental factors knowledge existing rhinitis international guidelines poorly complacence recommendations low epinephrine use anaphylaxis difference among european latin american elicitors predominance lactams nsaids drug hypersensitivity reactions inducers different regions fact hereditary angioedema patients receiving long term prophylaxis attenuated androgens mentioned clear examples relevant important data provided current registries summary registries allergy enlighten knowledge areas covered classical investigational methods number importance registries growing contribution knowledge management allergic diseases increase near future
background prevalence atopic dermatitis increased last years atopic dermatitis tends run families commonly begins manifest childhood prevalence atopic dermatitis high children thus early diagnosis treatment atopic dermatitis important understanding genetic basis also needed facilitate early detection methods identify family specific candidate genetic variants associated early onset atopic dermatitis koreans carried whole exome sequencing three separate families condition additional validation performed patients controls using sanger sequencing results focused common functional variants minor allele frequency higher rare variants minor allele frequency less relevance respective variants supported program could predict whether mutations resulted damaged protein function fourteen overlapping genes identified exome sequencing three variants cola gene appeared three families close proximity atopic dermatitis related loci chromosome homozygous frequency minor allele allele heterozygous frequency higher cases compared controls population based case control study conclusion identifying family specific cola polymorphisms genetic variants candidate genes associated using wes novel approach study suggests cola variants may risk factors atopic dermatitis study provides genetic basis early onset diagnosis korean patients development new therapies
physical activity increasingly recognised important factor within studies osteoarthritis however subjective methods used assess highly variable developed use within studies creates difficulties comparing interpreting data research aim study therefore gain expert agreement appropriate methods harmonise data among existing population cohorts enable investigation association definition context methods harmonization established via international expert consensus meeting modified delphi exercise using geographically diverse committee selected basis individual expertise physical activity exercise medicine agreement met aims study use metabolic equivalent task met minutes per week met min week method harmonising variables among cohorts determination methods treating missing components met min week calculation value produced comparable activities within representative cohort exclusion domain occupation total met min week need specific measure joint loading activity addition intensity time studies diseases study developed systematic method classify harmonise existing cohorts also provides minimum requirements future studies intending include subjective measures
objective future children health insurance program chip uncertain survey based research shows positive associations chip expansions children healthcare utilization build prior work used electronic health record ehr data assess temporal patterns healthcare utilization oregon chip expansion hypothesized increased post expansion utilization among children gained public insurance methods using ehr data oregon community health centers conducted retrospective cohort study pediatric patients years old gained public insurance coverage oregon expansion compared continuously publicly insured continuously uninsured year study period compared pre post rates primary care visits well child visits dental visits within groups also conducted longitudinal analysis monthly visit rates comparing three insurance groups results oregon chip expansions newly insured patients utilization rates double pre expansion rates adjusted rate ratios confidence intervals increases ranged primary care visits dental visits utilization among newly insured spiked shortly coverage began leveled remained higher uninsured group conclusions study used ehr data confirm chip expansions associated increased utilization essential pediatric primary preventive care findings timely pending policy decisions could impact children access public health insurance united states
hundreds papers job scheduling distributed systems published every year becomes increasingly difficult classify analysis revealed half papers barely cited paper presents general taxonomy scheduling problems solutions distributed systems taxonomy used classify make publicly available classification scheduling problems solutions problems clustered ten groups based features taxonomy proposed taxonomy facilitate researchers build prior art increase new research visibility minimize redundant effort
background imagine assessed week efficacy safety adalimumab children moderate severe crohn disease long term efficacy safety adalimumab patients entered imagine extension reported methods patients completed imagine could enroll imagine endpoints assessed weeks imagine pediatric crohn disease activity index remission pediatric crohn disease activity index imagine baseline using observed analysis hybrid nonresponder imputation hnri hnri discontinued patients imputed failures unless transitioned commercial adalimumab study site closure adult care last observation carried forward corticosteroid free remission patients receiving corticosteroids imagine baseline discontinuation immunomodulators imms patients receiving imms imagine baseline linear growth improvement reported observed adverse events assessed patients receiving adalimumab dose imagine january results patients enrolled imagine achieved remission response hnri imagine week remission rates maintained hnri patients entered imagine remission imagine week patients receiving corticosteroids imagine baseline achieved corticosteroid free remission patients receiving imms imagine baseline discontinued imms adalimumab treatment led growth velocity normalization new safety signals identified conclusions efficacy safety profiles prolonged adalimumab treatment children crohn disease consistent imagine adult crohn disease adalimumab trials
backgroundjanus kinase jak plays important role normal hematopoietic growth factor signaling detection jak mutation gnt gtc ttc crucial diagnosis myeloproliferative neoplasm mpn become essential criteria diagnosis mpn high resolution melt hrm curve analysis nongel based closed tube method pcr amplification subsequent analysis sequentially performed well making convenient scanning methodologies methodswe evaluated jak mutation hrm twenty nine patients diagnosed mpn examined studied analytical sensitivity hrm analysis using real time polymerase chain reaction pcr identifying jak mutation additionally sensitivity hrm analysis allele specific pcr pcr assay compared resultsthe jak mutation successfully discriminated abundance hrm analysis hrm analysis pcr showed accuracy detection limits respectively conclusionhrm analysis fast simple reliable nonexpensive method detection jak mutation however validation detection limits hrm analysis performed declaration analytic sensitivity method
nicotine dependence defined dopaminergic neuronal activation within nucleus accumbens acb affected neural projections nicotine stimulated neurons control subsequent neural activities would underpin smoking cessation strategy extensive efforts made study pathophysiology nicotine addiction limited works developed find imaging biomarkers biomarkers made available addictive behaviors could monitored noninvasively ends employed manganese enhanced magnetic resonance imaging memri determine whether could used monitor neuronal activities acute chronic nicotine exposure rats following observed infusion identified acb hippocampal hip neuronal activities following acute nicotine administration chronic exposure achieved week long subcutaneously implanted nicotine mini pump nicotine shown activate neurons acb hip prefrontal insular cortex central nervous system reward regions linked drug addiction conclusion memri demonstrated powerful imaging tool study brain subregion specific neuronal activities affected nicotine thus posit memri could used assess smoking associated tolerance withdrawal serve pre clinical screening tool addiction cessation strategies humans
sex steroids widely described associated number human diseases including hormone dependent tumors several studies concerned factors regulating availability sex steroids importance pathophysiological aspects reproductive cancers women premenopausal women large fluctuations concentration circulating estradiol progesterone orchestrate many events across menstrual cycle menopause levels circulating decline remain high concentration peripheral tissues notably strong relationship circulating sex hormones female reproductive cancers ovarian breast endometrial cancers hormones activate number specific signaling pathways binding either estrogen receptors ers especially alpha alpha beta progesterone receptors prs importantly course disease depend particular transactivation pathway identifying positive tumors benefit patients terms proper endocrine therapy based hormonal responsiveness effective prevention methods ovarian breast endometrial cancers represent special opportunity women risk malignancies hormone replacement therapy hrt might significantly increase risk cancer types endocrine treatments targeting signaling may helpful dependent tumors review present role sex steroids receptors associated risk developing female reproductive cancers emphasis levels pre postmenopausal women addition new therapeutic strategies improving survival rate outcomes women addressed elsevier inc rights reserved
purpose review gastrointestinal side effects particularly regard alimentary tract mucositis chemotherapy induced nausea vomiting cinv continue frequent debilitating symptomatic conditions among children adolescents receiving cytotoxic cancer therapy avenues progress mucositis cinv prevention paediatric oncology setting warranted recent findings current article reviews major guidelines literature published pertaining prevention mucositis cinv considerable professional organizational efforts made develop consensus based evidence based guidelines periodically update define basic standards mucositis cinv prevention published works may contribute emerging evidence prevention mucositis cinv paediatric setting future guideline updates summary concomitant use receptor antagonist dexamethasone effective prevent acute delayed cinv children receive highly moderately emetogenic chemotherapy optimal control acute delayed cinv prevent anticipatory cinv oral care protocols would beneficial prevent mucositis children across cancer treatment modalities cryotherapy low level light therapy may applied cooperative children undergoing chemotherapy haematological stem cell transplant conditioning regimens high rate mucositis
anaplastic large cell lymphoma alcl one common peripheral cell lymphomas incidence higher blacks non hispanic whites alk positive alk negative alcl distinct subtypes different characteristics clinical outcomes breast implant associated alcl rare lymphoma good survival outcome recent study showed total capsulectomy essential treatment brentuximab vedotin standard treatment relapsed refractory alcl response rate high however disease progresses patients survival outcome poor median overall survival less two months
notch important geometry widespread applications engineering structural components finding universal equation predict effect notch strength materials much significance structural design materials selection present work tried find universal equation experimental results metallic glasses mgs materials well theoretical derivations based universal fracture criterion zhang sci rep experimental results showed notch effect studied affected notch geometry characterized stress concentration factor becomes smaller notch strength ratio nsr ratio nominal ultimate tensile strength uts notched sample uts unnotched sample increases comparing mgs materials like brittle ceramics ductile crystalline metals find nsr larger ductile metals smaller brittle ceramics theoretically derived universal equation notch effect strength materials nsr constant related materials universal equation found consistent experimental results
background young individuals anorexia nervosa recovered display impairments social function date however clear whether differ controls respect neurocognitive performance whether functions contribute compromised social function observed individuals methods included young females first episode individuals recovered adolescent onset control individuals without comorbid autism spectrum disorder compared performance participants across groups seven neurocognitive functions relevant social functioning set shifting local processing processing speed working memory sustained attention verbal memory verbal abstraction tested association neurocognitive function social function measured autism diagnostic observation schedule ados ordinal logistic regression model results first participants differ neurocognitive function across groups second neurocognitive function verbal memory significantly associated social function higher performance verbal memory associated lower odds impaired social function diagnostic group remained significant factor absence interaction group neurocognitive performance indicated association verbal memory social function independent group membership conclusion young individuals recovered differ controls respect neurocognitive performance verbal memory associated social function groups
purpose paper aims explore feasibility rapid prototyping human hand bones additional artery topological preservation design methodology approach serial slices derived spiral computed tomography human hand specimen imported dslicer obtain three dimensional virtual model model exported standard template library file additional arteries structured according atlas bone model real model printed based virtual model measurements approached parts virtual real model findings statistical difference virtual real model parts topological characters preserved practical implications method used reconstruction clinical iconological blood vessel anatomical education originality value paper shows possible keep topological structure blood vessel painting also clinical data
research participants sexual orientation consistently taken account experimental psychological research argue research related participant target gender corroborating argument example study presented gender bias face recognition finding women correctly recognize female male faces contrast findings male participants inconclusive online experiment carried purpose sampling lesbian gay participants findings demonstrate pro female gender bias face recognition modified male participants sexual orientation heterosexual women lesbians well heterosexual men showed pro female gender bias face recognition whereas gay men showed pro male gender bias consistent explanation differences face expertise develop congruent interests results contribute growing evidence participant sexual orientation used distinguish alternative theoretical explanations given gender correlated patterns findings
paper deals production performance evaluation comparison among selected countries information communication sectors period estimate translog stochastic production frontier using corrected ordinary least squares cols method total information communication sector also two parts telecommunications computer programming consultancy information service activities also compare distribution malmquist productivity index decomposition technical technological changes results confirmed translog production function preferred cobb douglas functional form neutral technical progress estimated technical efficiency highest whole sector slightly lower subsector development malmquist productivity index sector information communication services exhibits declining trend followed moderate rise till year another slight declining based decomposition malmquist index observed technology efficiency change seems rather small effect productivity growth
paper propose novel architecture deep learning system named degree layer wise network realize efficient geo distributed computing cloud internet things iot geo distributed computing extends cloud geographical verge network neighbor iot basic ideas proposal include degree constraint layer wise constraint degree constraint defined degree vertex layer exactly extend existing deep belief networks control communication cost layer wise constraint defined layer wise degrees monotonically decreasing positive direction gradually reduce dimension data prove degree layer wise network sparse typical deep neural network dense evaluation distributed mnist database proposal superior state art model terms communication cost learning time scalability
job scheduling important topic parallel systems although exist algorithms theoretically provide optimal performance general complex implementation real production systems simplest feasible approach provides efficient fair scheduling backfilling fact backfilling used many real production systems scheduling policies widely studied discussed still big field research explored since scheduling algorithms motivated performance also psychology queuing fairness concept article propose algorithm fattened backfilling provides backfilling opportunities consequently efficient particular algorithm allows short jobs move forward delay first job queue average waiting time already finished jobs results simulations show great improvement response time waiting time cases improved similar slowdown values hence conclude fattened backfilling outperforms conservative easy backfllling due simplicity recommended implementation modern scheduling systems elsevier inc rights reserved
symbolic computation two classes lump solutions dimensionally reduced equations dimensions derived respectively searching positive quadratic function solutions associated bilinear equations guarantee analyticity rational localization lumps two sets sufficient necessary conditions presented parameters involved solutions localized characteristics energy distribution lump solutions also analyzed illustrated
framework storm water management domestic rainwater harvesting drwh systems recently recognized source control solutions according lid principles order assess impact systems storm water runoff control simple methodological approach proposed hydrologic hydraulic modelling undertaken using epa swmm drwh implemented model using storage unit linked building water supply system drainage network proposed methodology implemented residential urban block located genoa italy continuous simulations performed using high resolution rainfall data series nothing drwh scenarios latter includes installation drwh system building urban block referring test site peak volume reduction rate evaluated rainfall events respectively equal percent average maximum values percent peak percent volume general adopted methodology indicates hydrologic performance storm water drainage network equipped drwh systems noticeable even design storm event years rainfall depth seems affect hydrologic performance least total depth exceeds elsevier ltd rights reserved
due increased regulations concerning urban stormwater runoff stormwater control measures scms bioretention ponds constructed stormwater wetlands becoming common feature urban periurban landscapes water quality hydrologic benefits scms generally well documented planning tools available optimize water quality benefits economic costs scm construction maintenance given rising interest potential regulation carbon emissions planning tool allows estimation carbon emissions associated scm construction maintenance also relevant pursuit objective work present framework carbon emissions attributable scms conveyances could predicted method applied present comparison carbon footprint eight common scms three stormwater conveyance types carbon embodied construction materials represented prominent part carbon footprint green roofs permeable pavement sand filters rainwater harvesting systems reinforced concrete pipes material transport construction dominated bioretention systems ponds wetlands level spreader grassed filter strips concrete lined swales despite accounting sequestration vegetation systems stormwater wetlands grassed swales predicted store carbon released construction maintenance elsevier rights reserved
colonic diverticulosis common condition western industrialized countries occurring people age years minority subjects experience symptoms fulfilling rome iii diagnostic criteria irritable bowel syndrome ibs diagnosis ibs like symptoms cases symptomatic uncomplicated diverticular disease sudd syndrome characterized recurrent abdominal symptoms attributed diverticula absence macroscopically evident alterations presence diverticula due different peak incidence overlap sudd ibs predominantly present middle aged older patients cases complex establish symptoms related presence diverticula due overlapping ibs fact link gastrointestinal symptoms diverticula unclear mechanism diverticula may induce development ibs like symptoms remains elucidated currently etiology pathophysiology sudd particularly ibs like symptoms present completely understood thus two entities remain diagnostic challenge general practitioner also gastroenterologist although many issues remain open unresolved minimize importance distinction two entities dietary pharmacological management may largely overlapping
background moseley published randomized controlled trial rct showed difference knee arthroscopy placebo patients osteoarthritis wanted assess impact trial clinical practice united states purpose hypothesis evaluate changes knee arthroscopy practice publication article moseley assess effect landmark rct behavior practicing orthopaedic surgeons hypothesized publication moseley trial overall frequency knee arthroscopy would decrease mean age patients undergoing knee arthroscopy would decrease proportion arthroscopies diagnosis would decrease study design descriptive epidemiology study methods state ambulatory surgery database used analyze cases classified meniscus tear meniscus tear changes age surgery rates case classification evaluated moseley trial using student tests analysis variance results publication trial number knee arthroscopies per year increased mean patient age increased years meniscus tears increased representing approximately additional cases per year decreased representing approximately fewer cases per year meniscus tear increased representing approximately additional cases per year conclusion overall age rates knee arthroscopy increased contrary hypothesis identified decrease rates knee arthroscopy publication moseley trial demonstrating well publicized rcts influence patterns clinical practice
paper investigate existence compact random attractor random dynamical system generated model nonlinear oscillations floating beam equation strong damping white noise
purpose previous research determined relevance masticatory performance regard nutritional status cognitive functions stress management addition measurement masticatory efficiency contributes evaluation therapeutic successes within stomatognathic system however question remains unanswered extent modern techniques able reproduce subtle differences masticatory efficiency within various patient groups purpose review provide extensive summary evaluation masticatory performance means color changeable chewing gum regard clinical relevance applicability study selection general overview describing various methods available task already published review focuses depth research findings available technique measuring masticatory performance means color changeable chewing gum described mechanism differentiability color change methods evaluate color changes subsequently research masticatory performance conducted regard patient age groups impact general diseases effect prosthetic surgical treatment results studies indicate color changeable chewing gum valid reliable method evaluation masticatory function conclusion apart methods clinical practice technique enhance dental diagnostics well assessment therapy outcomes japan prosthodontic society published elsevier ltd rights reserved
objectives evaluate activity safety hydralazine valproate transkrip cutaneous cell lymphoma ctcl methods previously untreated progressive refractory ctcl patients received hydralazine day slow rapid acetylators respectively plus magnesium valproate total dose daily continuous day cycles phase study primary objective overall response rate orr measured modified severity weighted assessment tool swat secondary end points time response ttr time progression ttp duration response dor progression free survival pfs overall survival safety results fourteen patients enrolled untreated pretreated orr complete partial two stable disease two progressed median follow months median ttr months median dor months median pfs reached differences median ttr dor pfs treated pretreated patients pruritus relieve complete patients grade toxicities observed conclusion combination hydralazine valproate safe well tolerated effective ctcl
mechanical systems rotary machines rotating elements experience torsional vibration may lead extreme damage wear conventionally isolate undesirable structural vibrations passive elastomer torsional dampers used however passive vibration isolators adaptive varying oscillation frequencies real time due need real time adaptability controllable stiffness research development smart material called magnetorheological elastomer mre interest paper presents mathematical modelling development mre implication torsional vibration control based model experimental studies properties mre stiffness transmissibility factor regard varying magnetic fields investigated change magnetic field achieved changing amount applied current found stiffness mre increases increasing magnetic field consequently modifies system natural frequency allows shift transmissibility curve achieve minimum transmissibility factor applications involving varying frequency
typical starting current asynchronous three phase electric motor range five ten times rated current mitigate problems caused high current various methods start type motor exist alternative method starting induction motors new starting current limitation method proposed based using commercially available high temperature superconductor tape prototype superconducting starting current limiter constructed tested industrial induction motor three phase power grid total starting time longer time superconductor tape support high current shunt reactor receives starting current avoid damage tape performance evaluations superconducting limiter method performed compared direct line starter electronic soft starter addition limiting starting current method offers reduced current waveform distortion lower harmonic pollution startup
depression characterized sadness purposelessness irritability impaired body functions depression causes severe symptoms several weeks dysthymia may cause chronic low grade symptoms treatment depression involves psychotherapy medications phototherapy clinical experimental evidence indicates appropriate diet reduce symptoms depression neurotransmitter serotonin synthesized brain plays important role mood alleviation satiety sleep regulation although certain fruits vegetables rich easily accessible cns due blood brain barrier however serotonin precursor tryptophan readily pass blood brain barrier tryptophan converted tryptophan hydroxylase htp decarboxylase respectively presence pyridoxal phosphate derived vitamin hence diets poor tryptophan may induce depression essential amino acid naturally abundant even protein rich foods tryptophan rich diet important patients susceptible depression certain females pre postmenstrual phase post traumatic stress disorder chronic pain cancer epilepsy parkinson disease alzheimer disease schizophrenia drug addiction carbohydrate rich diet triggers insulin response enhance bioavailability tryptophan cns responsible increased craving carbohydrate diets although serotonin reuptake inhibitors ssris prescribed obese patients depressive symptoms agents incapable precisely regulating cns serotonin may cause life threatening adverse effects presence monoamine oxidase inhibitors however cns serotonin synthesis controlled proper intake tryptophan rich diet report highlights clinical significance tryptophan rich diet vitamin boost serotonergic neurotransmission depression observed various neurodegenerative diseases however pharmacological interventions modulate serotonergic neurotransmission depression remains clinically significant depression may involve several molecular mechanisms discussed briefly report elsevier ltd rights reserved
emerging evidence revealed honesty trustworthiness important drivers impression formation process questions remain however regarding role moral attributes guiding real concrete behaviors filling gap present study investigated influence honesty nonverbal behavior regulates social interactions behavioral synchrony movements recorded participants interacted partner depicted honest versus dishonest friendly versus unfriendly results showed synchrony affected honesty partner specifically interaction partner lacked honesty lower perceived similarity self interaction partner turn diminished promptness engage behavioral synchrony findings connected literature behavioral synchrony implication morality social perception revealing key role honesty facet moral character shaping nonverbal behaviors
paper presents review methods computer aided process planning application fields use computer aided manufacturing engineering system sat study indicates necessity expose shorteornings methods also article presents analysis process planning methods lithuanian sme describes possible improve application methods using system sat
eliminating leakage current one important issues transformerless three phase photovoltaic systems paper leakage current elimination three phase four leg inverter investigated common mode loop model established generation mechanism leakage current clearly identified different typical carrier based modulation methods corresponding common mode voltages discussed new modulation strategy boolean logic function proposed achieve constant common mode voltage leakage current reduction finally different modulation methods implemented tested tmsf dsp xcs fpga digital control platform experimental results verify effectiveness proposed solution
paper presents design simulation fabrication frequency selective surface fss based unit cell structure flexible polyimide film effective electromagnetic absorption proposed fss structure designed using splitted rings unit cell dimensions selected effective absorption band simulated results show absorption ghz film thickness proposed absorber film effectively used radar cross section rcs reduction cubical object proposed structure fabricated tested electromagnetic absorption well rcs reduction close match simulated experimental results observed proposed fss structure ultrathin flexible flame retardant makes good potential candidate stealth technology
background addition known concerns regarding antibiotic overuse recent research indicates excessive antibiotic use associated poorer long term health given rhinosinusitis leading condition accounting antibiotic prescriptions ambulatory setting aimed evaluate characteristics associated greater antibiotic use chronic rhinosinusitis crs methods adult crs patients enrolled prospective multi institutional observational cohort study evaluating treatment outcomes included analysis study participants asked report number days previous days systemic antibiotics taken sinus disease patient demographics disease characteristics measures disease severity evaluated results total patients institutions included analysis mean antibiotic use prior days differences antibiotic use groups found objective measures disease severity computed tomography endoscopy brief smell identification test bsit scores however increased patient reported symptom burden item sino nasal outcome test snot rhinosinusitis disability index rsdi associated antibiotic use patients reporting antibiotic use older ethnic gender differences seen comorbid diagnoses allergy asthma diabetes depression fibromyalgia associated increased antibiotic use accordance literature recommendations crs nasal polyps crswnp patients less likely used antibiotics endoscopic sinus surgery ess significantly decreased antibiotic use conclusion variability antibiotic use crs appears driven symptom burden independent objective measures disease severity patient demographics presence comorbid disease clear guidelines essential define appropriate antibiotic use crs ars aaoa llc
levantine basin eastern mediterranean sea subject spatial seasonal variations primary production physical chemical properties short long term basis study monthly means daily modis product images averaged used characterize phytoplankton blooms different bioregions levantine basin selected products sea surface temperature sst chlorophyll alpha concentration chl alpha diffuse attenuation coefficient welling irradiance colored dissolved organic matter index cdo index results showed phytoplankton blooms spatially temporally variable occurred late autumn nile delta early spring late summer eastern coastline spring northeastern coastline northern coastline open water common bloom occurring winter nile delta found productive area levantine basin showing high chl alpha chl alpha present parallel variation indicating dominance case waters levantine basin cdom index shows phase shift chl alpha fluctuation strong inverse correlation observed chl alpha cdom index sst connoting indirect relation represented depression cdom summer photobleaching suppression chlorophyll alpha concentration due water stratification together nutrient stress overestimation chl alpha values signaled use cdom index suggesting correction plan latter study institute oceanology polish academy sciences production hosting elsevier
aim present study calculate process detonation combustion gas mixtures engines development verification transient mathematical model chemically reacting gas mixture flows incorporating hydrogen performed development computational model based mathematical one parallel computing supercomputers incorporating cpu gpu units carried investigation influence computational grid size simulation precision computational speed performed investigation calculation runtime acceleration carried subject variable number parallel threads different architectures implying different strategies parallel computation
main objective paper identify appropriate temporal scale modeling behavior rainwater harvesting tanks relation purpose built water saving stormwater retention potential etc tank water balance model coupled specific procedure determine long term series rainfall tank inflow toilet flushes tank outflow different daily sub daily resolution timescales developed model applied household case study detailed water demand data available measurements simulations show daily scale may reliably chosen evaluate tank water saving efficiency contrast sub daily resolutions least hourly time step needed evaluation tank retention efficiency limit inaccuracies especially small tanks high values water demand moreover preliminary results min time step show rainwater tanks help reducing rainfall intensity peak basically depending tank storage rainfall event characteristics
working status huge rotating mechanical equipment judged method detection processing acoustics analyzed variation sound reflected variation material percentage equipment sound caused different material percentage collected analyzed time frequency domain paper practical material percentage detection algorithm proposed frequency spectrum quantitative analysis material percentage determined procedure algorithm design includes calibration quantitative detection field detection results show effectiveness
background asymptomatic early stages glaucoma second leading cause blindness worldwide psychosocial factors taken consideration host diseases cancer heart disease autoimmune conditions date psychological issues ignored clinical management glaucoma objective work reviews relevant contributions health psychology perspective assessment treatment glaucoma emerging field psycho ophthalmology method provide scientific evidence regarding contributions psychology comprehension glaucoma bibliographic review three databases psicodoc psycinfo medline conducted spanning period results review yielded total studies published period analysed identified three areas health psychology made substantive contributions glaucoma screening monitoring treatment emotional impact patients suffering glaucoma adherence treatment effects stress intraocular pressure conclusions health psychology approach research therapy glaucoma must focus management negative affect associated diagnosis optimisation treatment adherence stress management intraocular pressure measurements
spectrum disease extends beyond rigid confines ankylosing spondylitis axial spondyloarthritis axspa encompasses non radiographic axspa axspa individuals without established radiographic changes clinical imaging axspa features definite sacroiliac joint changes pelvic rays broad consensus management axspa emerging among clinicians evidence base remains open question explore whether axspa treated similarly examined literature prevalence natural history disease burden treatment strong evidence axspa expressions disease approximately patients axspa develop radiographic disease years years figure may exceed axspa patients lower crp less spinal inflammation mri patients similar disease activity pain quality life impairment patients axspa manage well conservative treatment minority severe disabling symptoms anti tnf therapy demonstrated similar efficacy safety axspa current evidence clearly indicate anti tnf treatment inhibit limit bony progression basis conservative anti tnf treatment control symptoms function patients axspa need powerful treatments great thus treatment axspa consistent across axspa spectrum anti tnf agents available irrespective radiographic change according criteria applied
paper presents new automatic control system precisely automatically analyze complex harmonics occurring power distribution transformers proposed system consists pre amplification block digital signal processing block real time monitoring block applied development board microcontroller connected monitor harmonics real time individually affixed transformer existing expensive harmonics measurement systems take lot time analyze complex harmonics unlike conventional systems since system accurate automatic measurement provides low measurement errors small test overhead proposed system showed low measurement errors less well fast real time measurements approximately sec harmonics analysis compared external expensive equipment measurements hope new system provide industry simple inexpensive technique control analyze complex harmonics occurring distribution transformers
background honeybush extracts cyclopia spp incorporated skin care products treat conditions skin dryness function anti oxidant objective formulate honeybush formulations test antioxidant activity skin penetration skin hydrating effects materials methods semi solid formulations containing either cyclopia maculata cyclopia genistoides underwent accelerated stability studies membrane release studies franz cell skin diffusion tape stripping studies performed antioxidant potential determined thiobarbituric acid assay clinical efficacy studies performed determine formulations effect skin hydration scaliness smoothness weeks treatment volar forearm results formulations unstable months membrane release skin diffusion studies tape stripping showed formulations inconclusive results due extremely low concentrations mangiferin hesperidin present franz cell receptor compartments stratum corneum epidermis epidermis dermis layers skin honeybush extracts showed antioxidant activity concentrations compared toxin whereas mangiferin hesperidin show antioxidant activity semisolid formulations showed potential emit antioxidant activity formulations improved skin smoothness although improve skin hydration compared placebos maculata reduced skin scaliness larger extent placebos genistoides conclusion honeybush formulations penetrate skin however show antioxidant activity potential used improve skin scaliness smoothness
million workers employed healthcare sector globally daily risk exposed complex variety health safety hazards purpose study investigate impact arts activity well nursing staff october december nursing staff working hospital took part study lasted weeks intervention group took part silk painting activities week data collected using socio demographic questions warwick edinburgh mental well scale short form health survey questionnaire reeder stress scale multidimensional fatigue inventory art activities groups statistical data analysis included descriptive statistics frequency percentage mean standard deviation non parametric statistics analysis man whitney test wilcoxon signedranks test fisher exact test reliability analysis cronbach alpha level significance set intervention group tendency participation arts activity positive impact general health mental well reducing stress fatigue awaking creativity increasing sense community work control group show improvements intervention group reported enjoyment aspiring continue arts activity future research suggests arts activity workplace intervention used promote nursing staff well work
general method stability analysis power converters presented paper method based harmonic linearisation linear time periodic ltp analysis techniques single phase grid feeding inverter pll considered case study although stability analysis developed using average model converter obtained results extended switching model possible evaluate precisely boundary stability instability
research aims improve health outcomes patients however setting research priorities usually performed clinicians academics funders little involvement patients caregivers using processes lack transparency national workshop convened australia generate prioritize research questions chronic kidney disease ckd among diverse stakeholder groups patients ckd nephrologists surgeons nurses caregivers allied health professionals researchers generated voted intervention questions across treatment categories ckd stages non dialysis dependent peritoneal dialysis hemodialysis kidney transplantation highest ranking questions descending order follows effective lifestyle programs preventing deteriorating kidney function early ckd strategies improve family consent deceased donor kidney donation taking different cultural groups account interventions improve long term post transplant outcomes effective interventions post hemodialysis fatigue improve individualize drug therapy control post transplant side effects priority questions focused prevention lifestyle quality life long term impact prioritized research questions inform funding agencies patient consumer organizations policy makers researchers developing ckd research agenda relevant key stakeholders national kidney foundation inc
objective although clear evidence reproductive cycle events associated mood episodes women bipolar disorder studies examined relationships specific clinical characteristics disorder study aimed explore relationship mood symptoms associated reproductive cycle events features disorder indicative severe lifetime course method totally women least years age participated study subjects recruited specialist clinic black dog institute sydney australia results total women reported increases mood symptoms perimenstrual postnatal menopausal periods women earlier age onset depressive hypo manic episodes greater likelihood comorbid anxiety disorders rapid cycling mixed mood compared report reproductive cycle associated mood changes women experienced postnatal episodes also likely experience worse mood symptoms perimenstrually menopausally conclusion first reproductive cycle event related worsening mood associated severe lifetime course bipolar disorder second appears women greater propensity mood worsening reproductive cycle events replicated findings provide important information clinicians treating women reproductive cycle event mood changes highlight need improved therapeutics presentations
winter oilseed rape wosr major crop germany combining economic benefits high value crop rotation still lacks agronomically sound concepts site specific nitrogen fertilization since ecological challenges resulting high optimal rates low harvest index approaching wosr cropping systems optimizing fertilization becomes crucial recent studies showed importance taking autumnal uptake account estimating optimal rates wosr thus autumnal pivotal algorithm introduced study algorithm parameterized using data site specific fertilization trials optimized reduce fertilizer amounts afterwards tested different commercial farms northern germany autumnal uptake estimated using hyperspectral reflection measurements gained tractor mounted devices data processed application maps used application spring addition uniform optimal fertilization uniform application average rates calculated algorithm applied provide control treatments yield balance economic net revenue evaluated treatment yields site specific fertilization slightly lower uniform optimal treatment higher uniform application site specific amount significant cases balance significantly lower fertilizing site specifically instead applying uniform optimal rate net revenues slightly higher published elsevier
methodological considerations football injury epidemiology scarcely described aim study evaluate inter rater agreement injury capture rate injury categorization data registered two different prospective injury surveillance audits studying two norwegian male professional football clubs two consecutive seasons one audit used team based exposure tbe recording individual based exposure ibe number injuries recorded corresponding injury rates injuries exposure compared audits cohen kappa prevalence adjusted bias adjusted kappa pabak coefficients calculated injury variables injuries included ibe audit captured overall capture rate training match tbe audit injuries overall capture rate training match agreement analysis showed kappa pabak coefficients regarded almost perfect injury variables substantial variable injury severity conclusion capture rate training injuries slightly higher ibe recording interagreement injury categorization high
objective understand effective ways ems providers interact distressed family members field intervention involving recent impending hospital ooh pediatric death methods eight focus groups ems providers conducted urban rural settings november march sixty eight providers also completed short questionnaire specific event including demographics seventy eight percent providers males either african american hispanic average number years ems years asked team members managed family response dying child helpful families whose child suddenly unexpectedly dead ooh setting follow efforts family effective results professional response ems team critical family coping getting necessary support several critical competencies identified help family cope including ems provide excellent expeditious care seamless coordination allowing family witness resuscitation including attempts save child life providing ongoing communication whether child removed scene keeping family appraised happening critical exclusion families process cases suspected child abuse warranted giving tangible forms support calling friends family clergy along allowing family time child death giving emotional support follow gestures help families cope conclusion study revealed effective ways ems providers interact distressed family members ooh pediatric death
introduction advanced air flow limitation patients copd leads reduction vital capacity respiratory muscle strength exercise capacity however impact chest abdominal wall mobility unknown study aimed ascertain prevalence patients copd reduced chest abdominal wall mobility investigate effect reduced chest abdominal wall mobility pulmonary function respiratory muscle strength exercise capacity methods elderly male subjects copd chest abdominal wall mobility fvc fev fev fvc maximal inspiratory pressure imax maximal expiratory pressure emax min walk distance mwd assessed chest abdominal wall mobility measured using breathing movement scale regions upper chest lower chest abdomen reduced mobility defined value lower lower limit normal scale unpaired test mann whitney test multiple regression analysis performed results percentages subjects reduced mobility upper chest lower chest abdomen subjects reduced mobility significantly low fvc fev mwd region significantly low fev fvc pimax pemax abdominal region compared nonreduced mobility fvc mwd independently associated scale values region abdominal scale value respectively conclusions majority subjects copd reduced chest abdominal wall mobility independently associated fvc even though abdominal wall mobility relatively preserved compared chest wall mobility also independently associated mwd
background dignity therapy psychotherapy relieve psychological existential distress patients end life little known effect aim analyse outcomes dignity therapy patients advanced life threatening diseases design systematic review conducted three authors extracted data articles evaluated quality using critical appraisal skills programme data synthesized considering study objectives data sources pubmed cinahl cochrane library psycinfo years searched year dignity therapy development january dignity therapy used search term studies patients advanced life threatening diseases included results studies included quality studies high results grouped effectiveness satisfaction suitability feasibility adaptability different diseases cultures two five randomized control trials applied dignity therapy patients high levels baseline psychological distress one showed statistically significant decrease patients anxiety depression scores time showed statistical decrease anxiety scores pre post dignity therapy depression nonrandomized studies suggested statistically significant improvements existential psychosocial measurements patients relatives professionals perceived improved end life experience conclusion evidence suggests dignity therapy beneficial one randomized controlled trial patients high levels psychological distress shows efficacy anxiety depression scores design studies report beneficial outcomes terms end life experience research understand dignity therapy functions establish means measuring impact assessing whether high level distress patients benefit therapy
various daily activities continually require regulation internal state regulatory processes covary changes high frequency heart rate variability hrv marker parasympathetic activity specifically incidental increases hrv accompany positive social engagement behavior prosocial action little known deliberate regulation hrv role voluntary parasympathetic regulation prosocial behavior present novel biofeedback task measures ability deliberately increase hrv two large samples find participants able voluntarily upregulate hrv variation ability predicts individual differences altruistic prosocial behavior non altruistic forms prosociality assessed different measures findings suggest self induction parasympathetic states involved altruistic action biofeedback task may provide measure deliberate parasympathetic regulation implications study attention emotion social behavior elsevier rights reserved
paper elaborates sequential procedures monitoring validity volatility model state space representation describes dynamics daily integrated volatility observation equation relates integrated volatility measures realized volatility bipower variation line control procedures based volatility forecasting errors allow decide whether chosen representation remains correctly specified signal indicates assumed volatility model may longer valid performance approach analyzed within monte carlo simulation study illustrated empirical application selected stocks
failure understand evolutionary dynamics hypothesized limiting ability control biological systems increasing awareness similarities macroscopic ecosystems cellular tissues inspired optimism game theory provide insights progression control cancer realize potential ability compare game theoretic models experimental measurements population dynamics broadly disseminated tutorial present analysis method used train parameters game theoretic dynamics equations used validate resulting equations used make predictions challenge equations design treatment strategies data analysis techniques tutorial adapted analysis reaction kinetics using method initial rates taught undergraduate general chemistry courses reliance computer programming avoided encourage adoption methods routine bench activities
work describes restricted access material ram constituted porous octadecylsilane particles outer surface covered bovine serum albumin bsa stationary phase extract drugs plasma samples disposable pipette extraction dpx analysis liquid chromatography tandem mass spectrometry bsa phase simultaneously excluded macromolecules chemical diffusion barrier bsa network enrichment interior phase drug traces sorption hydrophilic barrier bsa allows small molecules drugs permeate hydrophobic part time excludes macromolecules chemical diffusion barrier bsa network optimization dpx variables sorption equilibration time exclusion endogenous compounds elution step improved sensitivity selectivity method presented linear range lower limit quantification upper limit quantification inter intra assay precision coefficients variation lower relative standard error rse accuracy ranging developed method successfully used determine five antipsychotics olanzapine quetiapine clozapine haloperidol chlorpromazine combination seven antidepressants mirtazapine paroxetine citalopram sertraline imipramine clomipramine fluoxetine two anticonvulsants carbamazepine lamotrigine two anxiolytics diazepam clonazepam plasma samples schizophrenic patients therapeutic drug monitoring elsevier rights reserved
water shortage water pollution important factors restricting sustainable social economic development typical coal resource exhausted city node city south north water transfer east route project china zaozhuang city water resources management faces multiple constraints transformation economic development restriction groundwater exploitation improvement water environment paper develop linear optimization model input output analysis study water resources management introduction three advanced sewage treatment technologies pollutant treatment reclaimed water production simulation results showed zaozhuang city realize annual gdp growth rate annual chemical oxygen demand cod emissions reduction rate proportion primary industry secondary industry tertiary industry would adjusted respectively amount reclaimed water supply could increased groundwater supply could decreased based simulation model proposes scientific reference water resources management policies including water environment control water supply plan financial subsidy realize sustainable development economy water resources usage
developed network robot system framework objective enabling practical deployment social robots provide real world services everyday social environments framework addresses practical issues social human robot interaction integrating ambient intelligence systems networked data stores human supervisors centralized planning elements system developed tested public commercial spaces shopping malls resulting flexible robot control architecture based practical real world requirements describe several elements system demonstrate examples use five years real world field deployments research finally present ubiquitous network robot platform unr internationally standardized high level architecture service robots based framework
recent years development cfd simulations increased knowledge fluid structure interaction problems trend particularly important floating offshore wind turbines fowts sailing boats however especially sectors two different fluids involved reliability cfd prediction tools requires experimental validations end complementary approach respect ocean wave basins need wind tunnel aero elastic dynamic tests paper presents customization degrees freedom dof motion simulator device hardware loop hil wind tunnel tests floating scale models step machine design loop motivated described kinetostatic synthesis obtained multi objective optimization using genetic algorithm inverse dynamic properties mapped workspace finally drive system mechanically sized using called alpha beta theory emphasis placed mechatronic design methodology different mechanisms requirements may considered elsevier ltd rights reserved
normal aging alzheimer disease associated reduction functional brain connectivity unknown connectivity patterns due aging compare investigate functional brain connectivity young adults mean age older adults mean age patients mean age mean mmse participants scanned different sessions resting state functional magnetic resonance imaging fmri resulting scans per group voxelwise connectivity functional networks compared groups corrected normal aging characterized widespread decreases connectivity multiple brain networks whereas affected connectivity default mode network dmn precuneus preponderance effects associated regional gray matter volume findings indicate aging amajor effect functional brain interactions throughout entire brain whereas distinguished additional diminished posterior dmn precuneus coherence
dynamic nature mobile hoc networks combined lack centralized infrastructure make security problem challenging issue networks main contribution paper propose secure efficient key management algorithm able satisfying requirement networks facing specific characteristics proposed algorithm fully distributed based system built based elliptic curve cryptography main advantage proposed algorithm gives superiority field research improvement performance security strength together proposed algorithm implemented much lower communication computation overhead comparison literature works also able update keys solves key escrowing problem analyzed analytically compared several recently proposed key management algorithms analysis shows superiority proposed algorithm comparison others furthermore simulator used exhaustive simulations simulation scenarios done large scale networks evaluate performance proposed algorithm also validate analytical results results show algorithm could provide confidentiality integrity authentication non repudiation order magnitude less computation communication overhead comparison former works elsevier rights reserved
nowadays consumers around world increasingly focused health beauty renewed consumer interest natural cosmetic products creates demand new products reformulated others botanical functional ingredients cosmetic products essential oils eos play major role fragrance ingredients optimize proprieties preservation well marketing image final product microencapsulation eos protect prevent loss volatile aromatic ingredients improve controlled release stability core materials importance eos cosmetic industry microencapsulation reviewed study also briefly introduction preparation microparticles presented important usual microencapsulation techniques eos well conventional encapsulating agents discussed despite fact microencapsulation eos promising extremely attractive application area cosmetic industry basic research needs carried better understanding biofunctional activities microencapsulated eos release modulation well effects others cosmetic ingredients storage time microparticles properties
cross sectional reliability study conducted normal participants establish normal values repeatability validity distal radioulnar joint translation measurements using ultrasound imaging static transverse images maximal supination neutral maximal pronation examined assess translation using method consistent rheumatoid arthritis subluxation ratio translation gripping weight supinated pronated positions compared non gripping translation significantly ulnar radial translation found pronation supination compared neutral gripping pronation produce statistically significant changes translation whereas changes produced gripping supination significant internal consistency deemed high rheumatoid arthritis subluxation ratio values measured using ultrasound imaging consistent previously documented values measured computerized tomography study demonstrated translational movement distal radioulnar joint reliably detected healthy participants using ultrasound imaging may reduce dependency imaging modalities diagnose distal radioulnar joint instability level evidence
empirical literature energy efficiency gap concentrates demand inefficiencies energy using durables markets finds evidence consumers underestimate future energy costs purchasing new appliance take broader view also consider impact imperfect competition using data refrigerator market find average energy consumption appliances sold period higher would observed scenario perfectly competitive market non myopic consumers one reason small gap market power actually reduces energy use elsevier rights reserved
gas liquid mass transfer around taylor bubbles moving meandering millimetric square channel locally visualized characterized present study colorimetric technique proposed dietrich implemented technique evolution equivalent oxygen concentration fields liquid slugs passing one several bends firstly described particular observed flow structure recirculation zones inside liquid slugs twisted split periodic bends centrifugal effect reaching several bends uniform concentration inside liquid slugs influence turning point joining two straight sections meandering channel also highlighted slowing gas liquid mass transfer clearly shown volumetric mass transfer coefficients determined last fitting experimental axial profiles averaged oxygen concentrations liquid slugs turning point ones predicted classical plug flow model elsevier ltd rights reserved
research explores idea making estimates media influence self others individuals often assume reinforcement existing attitudes rather assume media content necessarily creates changes attitudes consequently perceptions favorable attitudes issue result judgments media strengthen favorable attitudes perceptions unfavorable attitudes result judgments media strengthen unfavorable attitudes two studies conducted survey concerning attitudes toward affirmative action higher education experiment concerning responses news coverage responses media violence support perceived media reinforcement obtained news content lesser extent media violence results discussed terms providing framework interpreting third person perceptions
tropical countries rainfall rates high especially deforested areas atlantic rainforest cerrado southeastern brazil water dominant driving force erosion common method used restore degraded tropical lands plant nursery raised tree seedlings method always practical variety newer reforestation techniques become available biodegradable coir geotextiles combined native seeds used restore degraded forest areas effects climatic conditions seasonal cycle rain drought evaluated structural mechanical properties coir geotextile fibers treated lime analyses tensile strength coir fibers showed months exposure untreated fiber retained treated fiber initial strength two principal factors considered evaluating structural properties coir fibers environmental exposure initial cellulose retention stability lime treatment lignin degradation loss environment structural changes seen thermogravimetry tga fourier transforms infrared spectroscopy ftir analyses explained changes seen coir mechanical properties greater cellulose contents fiber structures treated lime explained greater tensile strength high young modulus measures first three months exposure local weather conditions considering lime treatment improved coir fiber properties lime applications indicated coir geotextiles used acidic brazilian cerrado soils published elsevier ltd
background physical emotional sexual abuse children major problem south africa severe negative outcomes survivors date known studies used data directly obtained community based samples children investigate prevalence incidence locations perpetrators child abuse victimisation study aims investigate prevalence incidence perpetrators locations child abuse victimisation south africa using multicommunity sample methods children aged years female interviewed households randomly selected census enumeration areas two south african provinces child self report questionnaires completed baseline year follow retention results prevalence lifetime physical abuse past year incidence lifetime emotional abuse incidence lifetime sexual abuse incidence children reported type lifetime victimisation reported lifetime multiple abuse victimisation main perpetrators abuse reported physical abuse primary caregivers teachers emotional abuse primary caregivers relatives sexual abuse girlfriend boyfriends peers conclusions first study assessing current self reported child abuse large community based sample south africa findings high rates physical emotional sexual abuse demonstrate need targeted effective interventions prevent incidence victimisation
tennis become sport popular chinese universities colleges universities opened sports tennis professional courses tennis characteristics factors sports injuries project relatively common even outstanding sports college students athletes injury inevitable sports injuries athletes fear emotion game training certain extent affected normal training many people believe damage inevitable idea train elite athletes coaches sports teaching workers responsibility sports colleges great harm
people readily make personality attributions images strangers faces investigated basis personality attributions made everyday naturalistic face images first study used highly varying ambient image face photographs test correspondence personality judgments big five dimensions known underlie range facial first impressions approachability dominance youthful attractiveness interestingly facial big five judgments found separate extent judgments openness extraversion emotional stability agreeableness mainly linked facial first impressions approachability whereas conscientiousness judgments involved combination approachability dominance second study used average face images investigate main cues used perceivers make impressions big five extracting consistent cues impressions large variation original images forming impressions strangers highly varying naturalistic face photographs perceivers mainly seem rely broad facial cues approachability smiling
last years low dimensional high dimensional chaotic systems implemented cryptography efficiency performance nonlinear systems play important role limited hardware implementations context low dimensional chaotic systems attractive high dimensional chaotic systems produce pseudorandom key stream used encryption purposes although low dimensional chaotic maps present security disadvantages used cryptography highly attractive due simple structure discrete nature less arithmetic operations high output processing relatively easy implement digital system paper proposed pseudorandomly enhanced logistic map pelm application novel pseudorandom number generator prng algorithm produces pseudorandom stream excellent statistical properties proposed pelm compared logistic map using histograms lyapunov exponents show higher benefits pseudorandom number generator contrast recent schemes literature present comprehensive security analysis proposed pseudorandom number generator based pseudorandomly enhanced logistic map prng pelm cryptographic point view show potential use secure communications addition randomness prng pelm verified complete random test suit national institute standards technology nist testu based security results arithmetic operations required high output rate proposed prng pelm scheme implemented secure encryption applications even embedded systems limited hardware resources
present work hydrodynamics mass transfer performance vapor liquid flow orthogonal wave tray owt column studied dry pressure drop operating range capacity graph overall column efficiency owt column investigated using pilot columns three dimensional cfd model developed within two phase eulerian framework insight two phase flow mass transfer behavior owt simulated results compared experimental data showed good agreement hydrodynamic mass transfer behaviors revealed aid velocity profiles streamlines interfacial area density distribution effects vapor liquid load factor murphree tray efficiency also studied simulations owt different waves showed pressure drop clear liquid height froth height murphree tray efficiency increase increase slope owt middle slope tended uniform foam layer comparison liquid phase component velocity owt ripple shows owt better performance froth layer distribution stability mass transfer data showed owt almost peak efficiency sieve tray also higher capacity stability suitable capacity expansion taiwan institute chemical engineers published elsevier rights reserved
context requirements engineering phase software development life cycle one main concerns software engineers select set software requirements implementation next release software many requirements proposed customers balancing budget customer satisfaction objective analyse efficacy quantum inspired elitist multi objective evolutionary algorithm mea quantum inspired multi objective differential evolution algorithm qmdea multi objective quantum inspired hybrid differential evolution mqhde solving software requirements selection problem method paper reports empirical evaluation performance three quantum inspired multi objective evolutionary algorithms along non dominated sorting genetic algorithm nsga comparison includes obtained pareto fronts three performance metrics generational distance spread hypervolume attained boundary solutions size pareto front results results reveal mqhde outperformed methods producing high quality solutions qmdea able produce well distributed solutions extreme boundary solutions conclusion hybridization differential evolution genetic algorithms coupled quantum computing concepts mqhde provided means effectively balance two issues multi objective optimization convergence diversity elsevier rights reserved
article uses analytical tool called dist space examine structural role guitar distortion hard rock heavy metal dist space facilitates categorizing comparing graphing changes composition distortion structure demonstrate distortion capacity generate motivic formal structures application robert morris generalization contour theory dist space couples sequential time sequentially ordered dimension discrete distortion regions whose foundation distortion function spectral analysis process categorizing comparing graphing distortion sounds partially subjective distortion function underlying dist space sequentially ordered dimension distortion regions provides objective foundation measuring identifying comparing distortion sounds informs subjective judgments leading greater intersubjective agreement theorists analysts performers although primary analytical focus dist space tool guitar distortion wider range applications example provide analytical insights distortion sounds recording engineers produce microphones tape machines digital analog signal processing become integral process producing tracks studio fact study demonstrates guitar distortion heard recordings often product guitar amplification recording studio techniques
aberrant connectivity believed contribute pathophysiology autism spectrum disorder asd recent neuroimaging studies increasingly identified impairments patients asd including alterations sensory systems however cellular substrates molecular underpinnings disrupted connectivity remain poorly understood utilizing eye specific segregation dorsal lateral geniculate nucleus dlgn model system investigated formation refinement precise patterning synaptic connections btbr btbr mouse model asd found neonatal stage shape dlgn occupied retinal afferents altered btbr group compared cbl animals notably degree overlap ipsi contralateral afferents significantly greater btbr mice moreover abnormalities continued mature stage btbr animals suggesting persistent deficits rather delayed maturation axonal refinement together results indicate disrupted connectivity synaptic patterning level btbr mice suggesting general altered neural circuitry may contribute autistic behaviours seen animal model addition data consistent notion lower level primary processing mechanisms contribute altered visual perception asd autism res authors autism research published wiley periodicals inc behalf international society autism research
goals study characterize temporal dynamics inter regional connectivity brain chronic headache patients versus age gender matched controls conch pairs determine whether dynamic measures reveal additional features static functional connectivity correlate psychometric scores cortical thickness inter regional resting state fmri connectivity quantified compared conch groups six cortical regions interest roi pairs exhibited correlated cortical thickness static functional connectivity abnormalities selected temporal dynamic analysis two methods used temporal sliding window wavelet transformation coherence vvtc analyses using three temporal windows revealed six roi pairs exhibited higher percentage strong connectivity high values smaller fast fourier transform fft amplitudes low frequency range compared conch features particularly prevalent window analysis less variable dynamic fluctuation smaller standard deviation values identified two six roi pairs wtc analysis revealed time averaged coherence generally greater conch wavelet decomposition scales statistically significant three six roi pairs together robust significant differences temporal dynamics conch detected two roi pairs left medial orbitofrontal left posterior cingulate left medial orbitofrontal left inferior temporal high degrees sleep disturbance high psqi score depression high hrsd score fatigue low score associated high degree inter regional temporal coherence summary dynamic functional connectivity dfc measures uncovered temporal lock condition subset roi pairs showing static functional connectivity changes patients study provides important evidence presence associated psychological wellbeing abnormal temporal dynamics specific cortical regions patients elsevier inc rights reserved
rapid cost effective analysis histamine food environmental diagnostics research interest recently however certain applications already existing biological receptor based sensing methods usage limits terms stability costs result robust cost effective imprinted polymeric receptors best alternative present work molecularly imprinted polymers mips histamine synthesized using methacrylic acid chloroform acetonitrile two different porogens binding affinity mips histamine evaluated aqueous media mips synthesized chloroform displayed better imprinting properties histamine demonstrate histamine mips incorporated carbon paste electrode mip electrode sensor platforms detection histamine simple sensor format allows accurate determination histamine sub nanomolar range using electrochemical method sensor exhibited two distinct linear response ranges detection limit sensor calculated equal specificity proposed electrode histamine demonstrated using analogous molecules neurotransmitters serotonin dopamine etc mip sensor investigated success spiked serum samples easy preparation simple procedure low production cost make mip sensor attractive selective sensitive detection analytes even less equipped laboratories minimal training
background migraine tic syndrome first reported year old woman concomitant symptoms typical trigeminal neuralgia migraine report two cases migraine tic syndrome speculate relevance condition pathophysiology headache case reports year old woman presented typical trigeminal neuralgia symptoms preceded onset migraine headache headache types responded treatment sumatriptan year old woman presented trigeminal neuralgia consistently followed onset migraine headache former aspect responded baclofen migraine headache required treatment amitriptyline discussion two patients provide support presence overlap syndrome migraine tic suggest common pathway trigeminal neuralgia migraine
last years effect diabatic test conditions compressor performance maps widely investigated leading authors propose different correction models aim paper investigate effect heat transfer phenomena experimental definition turbocharger maps focusing compressor performance work developed within collaboration polytechnic school university genoa italy testing center critt france particular original model correction compressor steady flow maps presented discussed major benefit method represented easiness data post processing data base economy reduced number geometrical physical input parameters required accuracy solution besides model need standard test bench obtain compressor maps paper experimental tests quasi adiabatic conditions developed validate proposed model reported satisfactory agreement measured calculated compressor maps highlighted elsevier ltd rights reserved
ras radar absorbing structure effective load bearing electromagnetic wave absorbing capability stealth technology although ras usually designed absorb waves broadband range wave frequencies may effective absorb waves certain frequency range narrow band stop filter specific applications work non reflective conditions ras analytically investigated determine medium thickness wave transmission destructive interference sandwich type ras composed cnt carbon nanotube nano composite face pmi polymethacrylimide foam core carbon epoxy composite reflector fabricated wave absorbing characteristics ras measured free space measurement method develop high wave absorption characteristics flexural stiffness strengths ras measured three point bending method respect thickness carbon epoxy composite reflector elsevier ltd rights reserved
many problems systems control engineering formulated constrained optimization problems multivariate polynomial objective functions propose algorithms based polynomial spline form constrained global optimization multivariate polynomial functions proposed algorithms based branch bound framework tested proposed basic constrained global optimization algorithms considering three test problems systems control obtained results agree reported literature
background calcific aortic stenosis cas common heart valve disease elderly representing important economic social burden developed countries currently way predict either onset progression cas emphasizing need identify useful biomarkers condition methods performed multi proteomic analysis different kinds samples cas patients healthy donors tissue secretome plasma results validated independent cohort subjects immunohistochemistry western blotting selected reaction monitoring results alpha antichymotrypsin aact abundance altered cas samples confirmed validation phase significant changes observed amounts protein strongly suggest could involved molecular mechanisms underlying cas addition results suggest enhanced release aact extracellular fluids disease commences conclusions significant increase aact cas patients suggests fulfils important role physiopathology disease results permit propose aact may serve potential marker diagnosis cas considerable clinical value
backgroundit unclear whether cardiovascular risk factor modification influences development renal disease people type diabetes identified screening determined predictors albuminuria years diagnosis screen detected diabetes within addition europe study pragmatic cardiovascular outcome trial multifactorial cardiovascular risk management methodsin participants newly diagnosed screen detected diabetes without albuminuria explored associations risk new albuminuria mgmmol males mgmmol females baseline cardio metabolic risk factors changes baseline year systolic blood pressure sbp glycated haemoglobin hba using logistic regression resultsalbuminuria developed participants baseline body mass index active smoking independently associated new onset albuminuria years detection diabetes model adjusted age gender baseline hba blood pressure decrease hba mmhg decrease sbp first year independently associated lower risks albuminuria odds ratio confidence interval respectively adjustment materially change estimates interaction sbp hba relation albuminuria risk suggesting likely additive effects renal microvascular disease conclusionsbaseline measurements changes hba sbp year diagnosis diabetes screening independently associate new onset albuminuria years later established multifactorial treatment diabetes applies cases identified screening
year old man week history orthostatic headache acute chronic subdural hematoma presented imaging findings suggestive spontaneous intracranial hypotension threemyelogramswere negative leak nontargeted epidural blood patches result symptom relief cerebrospinal fluid leak study using dtpa spect demonstrated focal area asymmetric activity left nerve root left root tie targeted epidural blood patch dura seal glue resulted resolution patient symptomatology highlighting importance fused spect images detection occult cerebral spinal fluid leak
introduction crohn disease chronic immune mediated condition potentially disabling destructive course despite growing data use therapeutic top strategy clinical management complex disorder still challenging currently discussion top strategy mostly includes biological therapy alone combination areas covered article based review existing literature regarding use biological therapy top approach treatment crohn disease authors reviewed major databases including medline well ddw ecco abstracts respectively expert opinion top therapeutic approach crohn disease strongly supported existing data patients several risk factors severe course disease moreover increasing amount published data recommending individualised therapeutic strategy identify candidates top treatment based enhanced diagnostics using biomarkers emerging therapeutic approaches besides existing therapy concepts using biologicals may possibly redefine top therapeutic strategy crohn disease future
secure base script sbs framework one method assessing implicit internal working models attachment recently researchers applied method analyze narratives regarding relationship experiences study examines associations attachment avoidance sbs content parents recall positive moment connection children relational savoring well association parental emotion reflective functioning using sample parents female young children boys mage months found parental attachment avoidance inversely associated sbs content relational savoring sbs content indirect effect explaining association attachment avoidance postsavoring positive negative emotion well avoidance poststressor findings implications understanding attachment parenting
regulatory cells tregs subset cells suppressive function critical limiting inappropriate activation cells hence expansion tregs attractive strategy treatment autoimmune diseases demonstrate skin possesses remarkable capacity systemically expand treg numbers producing thymic stromal lymphopoietin tslp response vitamin receptor stimulation similar fold increase proportion absolute number tregs observed mice treated topically systemically vitamin analog expansion tregs dependent tslp receptor signaling vdr signaling hematopoietic cells however tslp receptor expression tregs required proliferation rather skin derived tslp promoted treg expansion dendritic cells importantly treatment skin significantly lowered incidence autoimmune diabetes non obese diabetic mice attenuated disease score experimental autoimmune encephalomyelitis together data demonstrate skin remarkable potential control systemic immune responses vitamin mediated stimulation skin could serve novel strategy therapeutically modulate systemic immune system treatment autoimmunity elsevier ltd rights reserved
paper discusses comparative study relate parametric non parametric mode decomposition algorithms response data three popular mode decomposition algorithms included study eigensystem realization algorithm natural excitation technique next era parametric algorithm well principal component analysis pca independent component analysis ica non parametric algorithms comprehensive parametric study provided different response types excitation types iii system damping sensor spatial resolution compare mode shapes modal coordinates using dof building model mode decomposition results also compared using unique dynamic response data collected ship bridge collision accident ambient excitation traffic loading ambient excitation without traffic loading impulse excitation
paper presents generalised optimal linear quadratic analog tracker lqat universal applications continuous time systems includes generalised optimal lqat design system pre specified trajectories output control input additionally input output direct feed term known estimated system disturbances extra input output signals new optimal filter shaped proportional plus integral state feedback lqat design non square non minimum phase systems achieve minimum phase like tracking performance new approach computing control zeros given non square system one learning epoch input constrained iterative learning lqat design repetitive system
prediction calculation eddy current losses occurring permanent magnets pms electrical machines great interest accurate results achieved using finite element simulations require long computation times elaborate models due methods applied final stage machine design process paper presents different methods calculate eddy current losses pms simulations radial solver combination axial solver developed enabling prediction eddy current paths three dimensions associated losses approach applicable surface mounted interior pms
chief characteristic japan postwar employment system built around needs large corporations higher rate lifetime employment deferred compensation reflected japan steeper age wage profile relatively late stage promotions late career tracking relative comparable nations however key attribute regular employment japan indefinite unrestricted nature received less attention deserves companies make guarantees regarding regular employees duties job locations working hours time hiring left indeterminate indefinite nature regular employment linked causes many employment problems diversification regular employment needs progress point job specific regular employment employees job contents clearly defined becomes new norm article presents policies must put place order shift occur
purpose study reveal gender differentiation food preparation consumption behaviors crystallizes iran end observations made tehran capital city iran period one month apart observations order able determine gender differentiations gender roles regard food preparation consumption interviews also held ten people different jobs genders ages using semi structured interview form result observations interviews stated modernizations taken place especially regard eating however found traditional gender patterns gender roles continue regard food preparation consumption home short food seen woman thing
craving central feature addiction precursor relapse targeted recently addiction intervention internet gaming disorder igd conceptualized behavioral addiction lack effective treatment practice exploration mechanism research aims test effectiveness detect active ingredients craving behavior intervention cbi mitigation igd among young adults total male college students igd assigned intervention group six session cbi intervention waiting list control group structured questionnaires administered pre intervention post intervention month follow month follow compared control group significant decrease severity igd intervention group found post intervention lasting months intervention value changes craving could partially mediate relationship intervention changes igd among effects tests immediate short term long term effects explorations active ingredients intervention found depression relief shift psychological needs internet real life significantly predict craving amelioration post intervention month follow although preliminary current study provides evidence value craving aimed intervention practice igd treatment identifies two potential active ingredients mitigation craving long term therapeutic benefits conferred registry name behavioral brain mechanism igd url https www clinicaltrials gov show nct registration number nct
polycyclic aromatic hydrocarbons pahs known carcinogenic teratogenic properties however little known effect pah immune respiratory systems hence investigated associations pah exposure ige levels asthma children pah exposure oxidative stress marker ohdg potentially involved disease pathogenesis stratifying sex based differences total kindergarten children recruited provided samples urine biomarker pah exposure ohp levels measured uplc marker oxidative stress ohdg measured elisa serum ige assessed information asthma collected associations ohp levels ohdg ige asthma analyzed multivariate linear logistic regression mediation analysis conducted evaluate whether risk increased ige asthma related pah exposure explained ohdg changes urine ohp levels positively related ohdg levels per unit beta similar results also found ohp levels ige levels per unit beta ohp levels per unit significantly associated asthma addition ohp levels associated asthma estimated effect pah exposure asthma mediated ohdg levels exposure pah may enhance oxidative stress may induce asthma effect pah exposure asthma may mediated oxidative stress
background previous studies suggested fear memories updated recalled process referred reconsolidation given beneficial effects model based safety learning vicarious extinction preventing recovery short term fear memory examined whether consolidated long term fear memories could updated safety learning accomplished vicarious extinction learning initiated within reconsolidation time window assessed final sample participants underwent three day within subject fear conditioning design using fear potentiated startle primary index fear learning methods day two fear relevant stimuli reinforced css paired shock third stimulus served control day one two previously reinforced stimuli reminded presented order reactivate fear memory min vicarious extinction training initiated css recovery fear memory tested later results conclusion vicarious extinction training conducted within reconsolidation time window specifically prevented recovery reactivated fear memory leaving fear potentiated startle responses non reactivated cue intact findings relevant basic clinical research suggesting safe non invasive model based exposure technique potential enhance efficiency durability anxiolytic therapies elsevier ltd rights reserved
flexibility resource efficiency time market key success factors industrial enterprises essential settings set early phases product development well manufacturing later product lifecycle phases responses market complains amount damage cases show maturity stage products quality methods like tqm efqm pursue goal permanently learn information therefore necessary adequate information supply article focuses problem context maturity stage management manufacturing engineering research therefore first identifies huge gap theoretically discussed information supply based encompassing data bases real existing heterogeneous landscapes grown history basis empirical findings industrial businesses lack concepts put position adequate information supply therefore generic business intelligence concept developed research activities seems promising approach thus possible combine information product features manufacturing information traditional dimensions managerial analysis order identify impacts engineering decisions product lifecycle authors published elsevier
pet mri powerful imaging techniques used extensively study diseases brain head neck many diseases including dementia epilepsy head neck cancers pet mri play important complementary roles standard diagnostic evaluation recent advances pet detector technology allowed combination pet mri single machine capable simultaneous imaging may offer several distinct advantages serial imaging post acquisition fusion decreased patient burden improved pet imaging quantification addition pet instrument potentially unique ability combine time dependent physiological functional information mri specific metabolic receptor specific information pet imaging past several years numerous anecdotal reports several larger studies showed feasibility pet various brain head neck applications including example concomitant fmri pet neuroreceptor imaging future well designed studies focus evaluating optimizing synergistic qualities combined technologies may fulfill promise pet mri provide unparalleled opportunities understand complex brain function pathology
present meta analysis integrates research studies associations parenting dimensions styles externalizing symptoms children adolescents parental warmth behavioral control autonomy granting authoritative parenting style showed small small negative concurrent longitudinal associations externalizing problems contrast harsh control psychological control authoritarian permissive neglectful parenting associated higher levels externalizing problems strongest associations observed harsh control psychological control parental warmth behavioral control harsh control psychological control autonomy granting authoritative permissive parenting predicted change externalizing problems time associations externalizing problems warmth behavioral control harsh control psychological control authoritative parenting bidirectional moderating effects sampling child age form externalizing problems rater parenting externalizing problems quality measures publication status identified implications future research practice discussed
exhaustive review use structured stochastic search approaches towards system identification digital filter design presented paper particular paper focuses identification various systems using infinite impulse response adaptive filters hammerstein models well estimation chaotic systems addition presenting comprehensive review various swarm evolutionary computing schemes employed system identification well digital filter design paper also envisioned act quick reference popular evolutionary computing algorithms elsevier rights reserved
objective aim study examine physical heart rhythm management device malfunction complications participating cardiac rehabilitation program intervention compared usual care method study clinical trial patients randomization intervention group patients received cardiac rehabilitation program sessions weeks follow phone calls session consisted exercise training education psychological interventions data collected points groups baseline weeks first day intervention using researcher designed case report form data analyzed using descriptive nonparametric tests results participants men sample aged years week follow less physical complications among cardiac rehabilitation group group differences complications related device malfunction heart rhythm device type cardiac rehabilitation greatest efficacy reducing physical complications patients cardioverter defibrillators conclusions cardiac rehabilitation reduced physical complications patients cardiac rhythm management devices especially patients cardioverter defibrillators cardiac clinical nurse specialists recommend rehabilitation programs part postimplantation rhythm device treatment decrease risk physical complications
last decades sports injuries pediatric adolescent athletes increased dramatically similar million young athletes participating organized sports annually united states starting age years increase incidence knee injuries adulthood peak years age observed due physiologic laxity ligaments ligament injuries uncommon patients getting frequent growing knee open physis points minor resistance therefore apophyseal injuries pediatric knee common diagnostics treatment ligament injuries pediatric adolescent knees challenging article presents overview ligament injuries pediatric adolescent knee diagnostic work treatment growing patient
objective evaluate efficacy safety subcutaneous golimumab methotrexate mtx patients active rheumatoid arthritis despite etanercept mtx adalimumab mtx therapy evaluate whether intravenous golimumab could rescue patients nonresponders golimumab methods multicenter assessor blinded active switch study patients inadequate response etanercept adalimumab mtx patients continued mtx received open label golimumab every weeks week das esr good responders week continued open label golimumab week group nonresponders randomized double blind golimumab group group week acr primary endpoint assessments continued week patients voluntary long term extension week major secondary endpoint proportions patients acr response week relative week group group results week achieved acr week patients group achieved acr groups acr week relative week significant difference randomized groups achieved das esr response relative week week patients serious adverse event differences rates types adverse events observed golimumab weeks trial limitations included higher expected discontinuation rate result programming error conclusion golimumab mtx significantly suppressed disease activity patients inadequate response etanercept adalimumab mtx patients randomized groups lower response rates group difference mode administration safety profile golimumab comparable established golimumab trial registration nct eudract
background objectives pivotal role oxidative stress emphasized pathogenesis well disease progression parkinson disease aimed investigating serum levels antioxidant vitamins elucidating whether could associated pathogenesis progression materials methods serum levels retinol alpha gamma tocopherols alpha beta carotenes lutein lycopene zeaxanthin cryptoxanthin measured compared patients idiopathic healthy controls matched age gender order examine relationship antioxidant vitamins disease progression multiple group comparisons performed among early hoehn yahr stage advanced stage iii control groups separate correlation analyses performed measured antioxidant vitamins clinical variables hoehn yahr stage unified parkinson disease rating scale updrs motor score results compared controls patients lower levels alpha beta carotenes lycopene alpha carotene beta carotene lycopene levels significantly reduced advanced patients relative early patients negatively correlated hoehn yahr stage updrs motor score patients significant differences found serum levels retinol alpha gamma tocopherols carotenoids patients controls significant correlations found vitamin levels clinical variables patients conclustions found serum levels carotenoids alpha carotene beta carotene lycopene lower patients carotenoids inversely correlated clinical variables representing disease progression findings suggest decreases serum alpha carotene beta carotene lycopene may associated pathogenesis well progression
natural rotation earth generates environmental day night cycle repeats every daily transition dawn dusk provides one important time cues majority organisms synchronise activity conditions natural light photic stimulus provides principal entraining cue mammals endogenous circadian pacemaker located within suprachiasmatic nucleus scn hypothalamus acts coordinating centre align physiological activity environmental light dark cycle however scn also receives regulatory input number behavioural non photic cues physical activity social interactions feeding routines unique ability scn integrate photic non photic cues allows generate rhythm tailored individual entrained environment review key neurotransmitter systems involved photic non photic transmission scn interactions assist generating entrained output rhythm also consider impact health desynchronised circadian system focus depressive affective disorders current therapies aimed manipulating relationship photic non photic scn regulators
asthma chronic airway inflammation characterized intense eosinophil infiltrates mucus hypersecretion airway remodeling airway hyperresponsiveness interleukin two cytokines anti inflammatory effects found immune response recent findings suggested expressions abnormal asthma functional analysis confirmed important roles pathogenesis asthma present study reviewed updated evidence indicating roles asthma hopefully information obtained may lead better understanding pathogenesis disease
hereditary angioedema hae esterase inhibitor deficiency autosomal dominant potentially life threatening disease characterized recurrent self limiting bouts edema involving mainly extremities genitalia face intestine airways prevalence hae range general population hae frequently misdiagnosed delays years onset initial symptoms diagnosis lanadelumab fully human igg monoclonal antibody plasma kallikrein pkal klkb showing potent selective inhibition pkal range subcutaneous route proof concept clinical trial showed long lasting efficacy tolerability prophylactic treatment hae two phase iii studies assess efficacy safety prevent angioedema attacks hae patients ongoing received orphan drug designation european medicines agency food drug administration fda well fda fast track breakthrough therapy designations prevention attacks hae
importance internet society increasing ensure functional internet routers need operate correctly however need router flexibility led use software programmable network processors routers exposes systems data plane attacks recently hardware monitors introduced network processors verify expected behavior processor cores run time instruction level execution deviates expected sequence attack identified triggering processor core recovery efforts manuscript describe scalable network processor monitoring system supports reallocation hardware monitors processor cores response workload changes scalability monitoring architecture demonstrated using theoretical models simulation router system level experiments implemented fpga based hardware platform system four processor cores six monitors monitors result percent logic percent memory bit overhead versus processor core logic instruction storage slowdown system throughput due monitoring reported
objective evaluate change levels anti mullerian hormone adiponectin weight loss fertility parameters obese women without polycystic ovary syndrome following weeks supervised aerobic exercise methods study conducted august october among obese women without polycystic ovary syndrome referred obstetrics gynecology clinic mansoura university hospital faculty medicine mansoura egypt patients classified three age matched groups group controls group patients polycystic ovary syndrome group obese women anti mullerian hormone adiponectin follicle stimulating hormone oestrogen fasting insulin fasting glucose homeostasis model assessment insulin resistance antral follicle count hirsutism score weight menstrual cyclicity ovulatory function assessed baseline following weeks supervised aerobic exercise statistical analysis performed using spss results patients group mean age years group years group group participants responded aerobic exercise interventions showed significant improvements reproductive function lower baseline anti mullerian hormone levels greater weight loss higher adiponectin level compared participants respond exercise programme weight loss fertility hormones follicle stimulating hormone prolactin oestrogen antral follicle count baseline anti mullerian hormone adiponectin significantly correlated improvement reproductive function change anti mullerian hormone adiponectin levels correlated significantly physical activity level responders non responders women anovulatory syndromes significant improvements ovarian process ovulation rate restoration menstrual cycle rate following weeks supervised aerobic exercise conclusion moderate aerobic training weeks positive significant effect reproductive functions via modulating adiposity levels adiponectin anti mullerian hormone fertility hormones
susceptibility bridge decks vortex induced oscillations addressed wind tunnel testing paper considers case vila real bridge north portugal highest deck ground among concrete deck bridges cable stayed central plane single cell rectangular box girder wide top flange supported regularly spaced inclined struts aeroelastic studies precise type deck seem nonexistent literature results sectional model tests presented selection three distinct angles attack three deck configurations including solution alternative usual mitigation measures solved susceptibility vortex induced vibration deck relevant additional design building costs proposed approach bridge designers may able relegate use sections high aerodynamic performance costly pose greater challenge construction require time completion use mitigation measures cases prove absolutely necessary elsevier ltd rights reserved
security information transmission paramount importance sectors society whether civilian defence related ancient times encryption secret messages mainly realized physical chemical means later supplemented mathematical techniques parallel breaking enemy codes also subject intense study date known absolutely secure means encryption quantum cryptography however still implemented equipment vulnerable various physical attacks important study methods attack legitimate users surveillance criminal activities today nearly transactions realized computer much effort devoted cracking software however little attention paid hardware recently realized computer chips leak sensitive information code may even deciphered studying photonic emission data dependency cryptographic chip operation correspondence hamming weight operand number photons emitted may established based simple effective method proposed crack advanced encryption standard aes cipher chip experimental platform set measuring analyzing leaked photonic emission using time correlated single photon counting atc microcontroller implementing operation aes cipher algorithm used cipher chip emitted photons collected first addroundkey subbytes aes encryption arithmetic executed respective numbers found linear relationship operand hamming weight sources noise affecting photon emission trace analyzed measurement error uncertainty reduced effectively help hamming weight simulation model selecting one several groups plain text comparing corresponding relationship hamming weight intermediate values number photons emitted cipher chip key aes encryption algorithm successfully recovered cracked confirms effectiveness method attack therefore pose severe threat security aes cipher chip next step future method optimized narrow search range also combined photonic emission analysis attacks simple photonic emission analysis differential photonic emission analysis improve efficiency comparison evaluation various methods made time current experimental configuration improved obtain better collection efficiency signal noise ratio
patients alzheimer disease triple transgenic xtgad mouse model low glucose metabolism brain precedes loss memory cognitive decline metabolism ketones brain passes glycolysis therefore may correct several deficiencies associated glucose hypometabolism dietary supplement composed ester beta hydroxybutyrate butane diol referred ketone ester incorporated rodent diet fed xtgad mice months months age animals killed brains dissected analyses carried hippocampus frontal cortex glycolytic tca tricarboxylic acid cycle intermediates amino acids oxidized lipids proteins enzymes higher concentrations beta hydroxybutyrate hippocampus fed mice also higher concentrations tca cycle glycolytic intermediates energy linked biomarker acetyl aspartate compared controls hippocampi control fed animals free mitochondrial nad nadh ratio highly oxidized whereas fed animals mitochondria reduced also levels oxidized protein lipids lower energy atp hydrolysis greater compared controls xtgad mice maintained supplemented diet higher concentrations glycolytic tca cycle metabolites reduced mitochondrial redox potential lower amounts oxidized lipids proteins hippocampi compared controls offers potential therapy counter fundamental metabolic deficits common patients transgenic models
background purpose hypertrophic pachymeningitis rare disease caused autoimmunity meninx causes various neurologic symptoms including headache seizures weakness paresthesia cranial nerve palsies although first line therapy steroids many cases refractory steroids recur steroids tapered report three cases successfully treated rituximab rtx methods institutional cohort recruited april july three cases identified steroid refractory treated rtx four weekly doses clinical improvement assessed number relapses neurologic symptom largest dural thickness mri results three patients recurrence free neurologic symptoms exhibited prominent decreases dural thickness rtx treatment adverse events observed patients conclusions suggest rtx second line therapy steroid refractory studies warranted confirm observation larger population consider rtx first line therapy
pneumatic systems widely used industrial applications well known advantages however pneumatic systems possess several disadvantages include strong non linearity low natural frequency drawbacks make difficult obtain satisfactory control performances comparison hydraulic electromechanical systems paper fundamental characteristics nonlinear synchronous control strategy pneumatic systems studied two layer sliding mode synchro system based friction compensation applied electro pneumatic cylinders synchro pid controller utilized position tracking validate developed strategy experiments cylinder electro pneumatic systems performed experimental results demonstrate synchronous position control scheme effective terms accuracy robustness
large amplitude oscillation steepled main cables usually presents construction long span bridge study phenomenon six typical main cables different cross sections construction investigated two main foci conducted firstly aerodynamic coefficients main cable obtained compared simulation wind tunnel test ensure simulation accuracy influences numerical model grid size jaggy edges main cable cross section main cable aerodynamic coefficients investigated aerodynamic coefficients main cables different wind attack angles obtained based wind tunnel test experimental model made rigid plastic using printing technology numerical results compared wind tunnel test results good agreement secondly aerodynamic coefficients six main cables different wind attack angles obtained numerical simulation den hartog criterion used analyze transverse galloping main cables construction results show six main cables may undergo galloping may important reason large amplitude oscillation steepled main cables construction flow structures around main cables indicate characteristic airflow trajectory steepled main cable may play important role galloping generation engineers take effective measures control harmful phenomenon due big possibility onset galloping construction period
carbon emission buildings leading indicator building low carbon goal paper based full life cycle starting point low carbon buildings established whole life cycle management model five subsystems analyzed discussed respectively guarantees construction low carbon management mode
flexible alternate current transmission systems facts controllers improve quality supply power enhance power system performance also provide optimal utilization existing resources especially thyristor controlled series compensator tcsc static var compensator svc proposed enhance power transfer capability improve quality voltage adjusting line reactance paper present study west algerian network furthermore try ask problems encountered practice find solutions moving towards facts devices particular tcsc svc controller application technical advantage software neplan used analyse behaviour west algerian electrical network without facts devices elsevier ltd open access article license http creativecommons org licenses selection peer review responsibility euro mediterranean institute sustainable development eumisd
experimental study investigated effect leader expression happy versus nervous emotions subsequent perceptions leadership ratings traits associated implicit leadership theories ilts fast universally understood emotions ideal stimuli investigating dynamic effects ilts understood study terms constraints expressed emotions impose connectionist networks activate ilts experimental design contrasted videotaped still frame presentations leadership event however methodological factor significant effects analyses thus collapsed across factor key findings expression happy versus nervous emotion end problem solving sequence multiple effects happy emotions resulted higher leadership ratings higher trait ratings greater correlations among trait ratings greater dependence trait ratings leadership perceptions exploratory model suggested leadership impressions mediated effects facial emotions trait ratings discussion links study findings interpretations terms ilts many types constraints cognitive structures also suggests ways integrate ideas advances neuroscience research elsevier inc rights reserved
objective social role functioning compromised majority individuals ultra high risk psychosis important identify factors contribute functional decline study aimed investigate social cognitive abilities previously linked functioning schizophrenia potential factors impact social role global functioning ultra high risk patients method total ultra high risk patients recruited established risk clinical service melbourne australia completed battery social cognitive neurocognitive clinical functioning measures examined relationships four core domains social cognition emotion recognition theory mind social perception attributional style neurocognitive clinical demographic variables three measures functioning global functioning social role scales social occupational functioning assessment scale using correlational multiple regression analyses results performance visual theory mind task visual jokes task significantly correlated concurrent role global functioning multivariate analyses also accounted unique variance global role functioning adjusting negative symptoms stress social functioning associated performance social cognition tasks conclusion among specific social cognitive abilities test theory mind associated functioning ultra high risk sample longitudinal research needed examine impact social cognitive deficits long term functional outcome ultra high risk group identifying social cognitive abilities significantly impact functioning important inform development targeted intervention programmes ultra high risk individuals
introduction immunotherapy targeting programmed death programmed death ligand checkpoint shown promising efficacy patients nsclc lymphocyte activating gene lag another important checkpoint role nsclc still clear study investigated lymphocyte activing lag protein expression correlation tumor infiltrating lymphocytes tils association survival nsclc methods expression lag epr abcam cambridge protein assessed nsclc cell lines immunohistochemistry lag nat cell marque rocklin dako carpenteria protein expression evaluated immunohistochemistry til abundance scored surgically resected specimens patients nsclc also verified results samples patients untreated nsclc detected correlation lag expression egfr kras mutation echinoderm microtubule associated protein like gene eml anaplastic lymphoma receptor tyrosine kinase gene alk rearrangement results lag expressed nsclc cell lines however lag expressed tils patients nsclc sixty patient samples positive tils positive tumor cells neither lag expressed tumor cells lag overexpressed tils nonadenocarcinoma compared adenocarcinoma lag expression tils significantly correlated tils tumor cells til percentage logistic regression model ors lag confidence interval nonadenocarcinoma compared adenocarcinoma tils negative compared positive recurrence free survival significantly different patients whose tils lag negative opposed lag positive years versus years likewise lag status tils negative versus positive significantly affect overall survival years versus years using kaplan meier analysis found patients negative tumor cells lag negative tils longer recurrence free survival patients either lag positive lag positive years versus years versus years verification stage high expression lag also significantly correlated higher expression tils tumor cells correlation lag expression egfr kras mutation alk fusion conclusions lag expressed tils tumor tissues patients nsclc expression higher nonadenocarcinoma correlated expression lag positivity lag positivity correlated early postoperative recurrence lag related poor prognosis international association study lung cancer published elsevier inc rights reserved
senescence develops cells sequentially acquire diverse senescent phenotypes along simultaneous multistage gene reprogramming remains unclear acts key regulator collective changes gene expression initiation senescent reprogramming analyzed time series gene expression profiles obtained two different senescence models human diploid fibroblasts replicative senescence induced senescence results demonstrate suppression dna methyltransferase dnmt mediated dna methylation activity initial event prior display senescent phenotypes identified seven dnmt interacting proteins ubiquitin like phd ring finger domains uhrf ezh chek suvh cbx parp hells also known lsh lymphoid specific helicase commonly regulated time point dnmt senescence models knockdown experiments revealed among dnmt interacting proteins uhrf knockdown suppressed dnmt transcription however uhrf overexpression alone induce dnmt expression indicating uhrf essential sufficient dnmt transcription although uhrf knockdown effectively induced senescence significantly attenuated dnmt overexpression clearly implicating uhrf dnmt axis senescence bioinformatics analysis identified wnta downstream effector uhrf dnmt mediated senescence senescence associated hypomethylation found base pairs transcription start site wnta gene senescent human diploid fibroblasts expected wnta overexpression induced senescent phenotypes overall results indicate decreased uhrf expression key initial event suppression dnmt mediated dna methylation consequent induction senescence via increasing wnta expression
aim study evaluate association crack cocaine addiction dental health men forty crack cocaine addicted patients nonaddicted patients years underwent full mouth dental examinations decayed missing filled teeth dmft identified using criteria recommended world health organization crack cocaine addiction determined based medical records interviews patient drug addicted patients used crack cocaine chi square test logistic regression analysis used assess association dmft crack cocaine addiction decayed teeth showed positive association crack cocaine addiction odds ratio confidence interval whereas filled missing teeth showed negative association filled teeth missing teeth dmft associated age present population crack cocaine addiction associated greater decayed teeth index lower filled missing teeth index programs aimed encourage self esteem encourage individuals seek dental care required population studies using larger sample size studies women required confirm results
despite nutritional value population level nut consumption remains low studies suggest individuals would eat nuts doctor advice making health professionals potentially important promoting nut consumption cross sectional study aimed examine perceptions knowledge nuts predictors nut promotion among health professionals new zealand dietitians general practitioners gps practice nurses identified electoral roll invited complete questionnaire respondents respectively one fifth gps practice nurses believed eating nuts could increase blood cholesterol concentrations cause weight gain common perceptions overall nuts healthy high protein fat calories satiating nut consumption recommended reasons relating perceptions nuts selenium content conversely reasons suggesting consumption fewer nuts included high calories fat would cause weight gain concerns regarding allergies cost groups health professionals likely promote nut consumption perceived nuts reduce risk diabetes education could improve health professionals knowledge regarding effects nut consumption blood cholesterol body weight alongside health benefits improve advice given patients may thereby increase nut consumption
keen interest enables rememberers differentiate true false memories strategies likely effective study measured electrical brain activity healthy young adults performed mnemonic discrimination task deciding whether color pictures studied similar studied pictures lures new post stimulus event related potentials erps correctly recognized studied pictures falsely recognized lures compared correctly rejected novel items left centroparietal scalp distribution typical parietal old new effect associated recollection line previous evidence similar lures may elicit false phantom recollection opposed familiarity evidence parietal effect correctly rejected lures would expected recall reject used erp old new effects lures also varied individual differences performance parietal effects falsely recognized lures larger better performers successfully rejected greater number lures similar better performers also showed pronounced right frontocentral old new effects correctly rejected falsely recognized similar lures enhancement false recollection better performers implies false recognition lures occurred specific information recovered study episodic together findings suggest reliance recollection decide items studied supported post retrieval processing elsevier rights reserved
germany high prevalence rates problematic alcohol use problematic internet use adolescents reported objective present study identify psychopathological factors associated two behavior patterns knowledge first investigation assessing psychopathological factors problematic alcohol problematic internet use sample adolescents surveyed sample adolescents germany regarding problematic alcohol use problematic internet use psychopathology psychological well conducted binary logistic regression analyses sample showed problematic alcohol use problematic internet use problematic alcohol problematic internet use problematic alcohol use higher adolescents problematic internet use compared without problematic internet use conduct problems depressive symptoms statistically significant associated problematic alcohol problematic internet use prosocial behavior related problematic internet use male gender less peer problems associated problematic alcohol use first time associations adolescent problematic alcohol problematic internet use due common psychopathological factors identified however addition shared factors found also specific psychopathological correlates associated two behavior patterns elsevier ireland ltd rights reserved
background multimorbidity affects majority elderly adults associated higher health costs utilization specific patterns morbidity influence resource use less understood objective objective identify specific combinations chronic conditions functional limitations geriatric syndromes associated direct medical costs inpatient utilization design retrospective cohort study using health retirement study linked medicare claims analysis used machine learning techniques classification regression trees random forest subjects population based sample medicare enrolled adults aged older united states measures main covariates self reported chronic conditions measured none mild severe geriatric syndromes functional limitations secondary covariates demographic social economic behavioral health status measures outcomes medicare expenditures top quartile inpatient utilization results median annual expenditures hospitalized within years tree model shows notable combinations self rated poor health plus activities daily living instrumental activities daily living disabilities expenditures top quartile inpatient utilization highest aged mild severe heart disease plus mild severe diabetes functional limitations important many chronic diseases explaining resource use conclusions multimorbid population heterogeneous considerable variation specific combinations morbidity influence resource use modeling conjoint effects chronic conditions functional limitations geriatric syndromes advance understanding groups greatest risk inform targeted tailored interventions aimed cost containment
backgroundpatients type diabetes mellitus increased risk death risk appears modulated kidney dysfunction aim study evaluate prevalence diabetic kidney disease dkd traits clinical correlates large sample patients type diabetes methodsclinical data patients type diabetes extracted electronic medical records estimated glomerular filtration rate egfr increased urinary albumin excretion considered resultsmean age patients years males duration diabetes years frequency diabetic kidney disease low egfr albuminuria respectively multivariate analysis presence diabetic kidney disease associated age odds ratio confidence interval duration diabetes worse glycemic control every glycated hemoglobin increase diabetic kidney disease also independently associated atherogenic lipid profile increased systolic blood pressure glucose control systolic blood pressure triglycerides high density lipoprotein cholesterol associated low egfr albuminuria male gender retinopathy smoke related albuminuria female related low egfr sua levels associated dkd low egfr albuminuria conclusionsin sample patients type diabetes diabetic kidney disease entails unsafe cardiovascular risk profile hyperglycemia arterial hypertension atherogenic lipid profile affected low egfr albuminuria retinopathy smoking related albuminuria female elevated serum uric acid associated low egfr
high number learners take part massive open online courses moocs anywhere time researchers give broad overview typical learners moocs many questions social cultural ethical dimensions elearning answered yet notwithstanding lot worldwide initiatives supporting girls women science technology engineering mathematics stem nevertheless countries especially western europe still far away gender parity stem line two aspects paper focuses learners countries data collected since enhanced survey data take part moocs computer sciences offered online learning platform openhpi primary interest concerns following research questions sociological point view takes part stem moocs selectivity factors influence successful participation men women stem moocs conditions moocs able promote gender diversity stem second chance education entry labor market aim paper raise potential moocs educate underrepresented groups specific fields like women stem analyzing learning behavior different kinds people giving recommendations mooc offers therefore analyze elearning moocs regard following social cultural ethical dimensions age gender socio demographic background subject field working experience social interaction among students forum learning groups students teachers tutors country residence values gender roles fairness behalf peer assessment conformity regulations concerning communication via forum report new results multivariate statistics give recommendations attracting women take part stem moocs regard role teachers course design learning materials examples speech geared diverse target group suitable learning environment heterogeneous group learners
ethnopharmacological relevance top flowering aerial parts hypericum species traditionally used prepare ointments heal cuts burns sometimes even fruits used purposes hypericum androsaemum commonly known tutsan shrubby john wort mediterranean medicinal plant traditionally used prepare ointment treating cuts wounds aim study evaluate extracts obtained androsaemum red berries functional ingredients skin care formulations materials methods methanolic extract obtained soxhlet extraction aqueous extract prepared decoction composition determined hplc analysis biological activities measured terms proliferation migration human fibroblasts inhibition collagenase activity immunomodulatory effects human peripheral blood mononuclear cells pbmcs addition evaluated photostability spectroscopy protective effects apph induced hemolysis red blood cells rbc results polar extracts contained significant amounts shikimic chlorogenic acids main components extracts made important contribution significant increase human fibroblast migration extracts also active collagenase inhibitors aqueous one showing greater inhibitory capacity value similar chlorogenic acid kinetic parameters determined enzymatic reaction revealed aqueous extract chlorogenic acid uncompetitive mechanism inhibition methanolic extract showed important effects pbmcs modulating extracts proved photostable uva range protected rbc peroxidation low concentrations conclusions androsaemum red berries proven contain phytochemicals improve skin regeneration hence potentially employable skin care formulations
cultural heritage documentation tasks usually involve professionals different knowledge areas implies huge amount information requirements also heterogeneous set sources data structures content formats geographic information systems gis used extensively cultural heritage specialists working around real problem specialized software professionals document work paper present software named agata allows specialists interact real time high resolution polygonal models annotate different raster vectorial information directly onto might useful current future research moreover annotations exported standard format allows researchers disciplines might interested dataset access information easily system able manage annotate buildings archaeological sites also sculptures paintings directly dataset physical element elsevier masson sas rights reserved
pedunculopontine nucleus ppn considered critically important region regulation physiological functions fail progression parkinson disease paper effects unilateral neurotoxic lesion ppn injection methyl aspartate nmda solution con centration volume motor execution gait disorders changes cellular molecular indicators rat nigral tissue evaluated motor execution assessed using beam test gait disorders footprint test glutathione gsh concentrations acetyl cholinesterase enzymatic activity ache brain derived neurotrophic factor bdnf mrna expression nigral tissue analyzed nmda lesioned rats showed fine motor dysfunction significant increase slow fast movement time path deviation smaller diameter beams moreover nmda lesioned rats exhibited imprecise path moments advances setbacks alternating left right deviations suspensions inverted positions footprint test revealed slight gait disorders manifested reduction left right stride lengths intra step distance support area biochemical studies showed ppn neurotoxic injury gsh concentrations bdnf expression significantly increased variables returned normal values days ppn lesion ache showed significant increase time functional changes nigral tissue could plastic responses associated early ibro published elsevier ltd rights reserved
paper presents state space representation method automatic development small signal model distribution network model represent dynamics converter interfaced wind photovoltaic generation units energy storage system around steady state operating point presented model considers voltages crossing capacitors currents inductors control variables state variables variations wind speed irradiance solar loads control input whole state space equations developed automatically detailed small signal mathematical model derived automatically using stamping method analyze small signal stability system time domain simulation used verify method effects system controller parameters system performance analyzed
landslide common natural disaster mountainous regions causes damages life properties study area calicut nilampur gudalurghat section falls survey india toposheet present study carried landslide hazard zonation mapping meso scale paper explains meso zonation landslide hazards facet wise made investigations per norms given bureau indian standard remote sensing geographic information system gis utilized preparation thematic maps scale present study evaluates detailed related factors inherent causative factors lithology structure slope gradient relative relief land use land cover hydrogeology involved landslides method also incorporates effects external causative factors like seismicity rainfall corrected rating study area different facets identified area falling facets come high hazardous zone slopes falling facets fall moderate hazardous zone facet low hazard zone facets show high hazardous zone details work presented paper landslide inventory points collected help gps ghat section inventory percentage comes low hazard zone present moderate hazard zone high hazard zone high hazard zone
investigate cervical compensation pattern clarify relationships cervical compensation quality life qol ankylosing spondylitis patients thoracolumbar kyphosis cross sectional study consecutive patients thoracolumbar kyphosis performed forty four patients hyperlordotic cervical spine assigned group sixteen kyphotic cervical spine group sagittal parameters measured compared including slope cervical lordosis cervical sagittal vertical axis sva global sva global kyphosis independent factors cervical compensation identified exclude confounding variables comparing qol patients hyperlordotic kyphotic cervical spine patients selected group similar patients group distribution matching variables age gender course disease global sva radiographic progression assessment qol assessed neck disability index ndi indices mean sva significantly lower group group whereas mean slope global sva significantly larger group slope independent factor slope correlated global sva group group showed lower ndi score independently affects ndi notable cervical compensation exists patients thoracolumbar kyphosis cervical compensation responsive global imbalance mediated slope patients hyperlordotic cervical spine present better qol patients kyphotic cervical spine
green building assessment emphasizes indoor environment quality ieq looking indoor air quality lighting quality acoustics ventilation thermal comfort conditions enhanced effective initiatives early design stage designers engineers usually consider exploiting passive designs achieve sustainable goal building projects background paper presents holistic passive design approach incorporating robust sensitivity analysis efficient multi objective optimization process assess typical high rise residential building hot humid regions like hong kong energyplus jeplus adopted conduct modelling experiments input parametric matrix generated latin hypercube sampling lhs related indoor environment performance indices including daylight natural ventilation thermal comfort treated optimization objectives constraints fulfil local green building guidance non dominated sorting genetic algorithm nsga coupled jeplus obtain pareto frontier thoroughly searching problem space constructed screened significant input variables sensitivity analysis furthermore different post optimization analysis methods applied decide final optimum solution total unmet time decreased contrast baseline case elsevier ltd rights reserved
hepatitis great burden health systems countries accounts million infected people worldwide approximately people worldwide died due hepatitis countries africa asia hepatitis accounts approximately population hepatitis accompanied cases neuropsychological diseases mainly depression depression seen hcv patients ifn treatment also developed treatment patients screen depression pre treatment treatment support family relatives also important helps patients better cope disease increase successful treatment chances treatment abandon also greatly reduced patients assisted therapist treatment full support family relatives large spectrum causes depression causes influenced gender social stigma education local culture etc rare occasions depression lead suicidal ideation attempts suicide attempts per represent high percentage hepatitis infected patients mortality due hepatitis virus per year death hepatocellular carcinoma accounting almost half total deaths number morbidity cases hcv virus together hiv mainly hepatitis responsible total deaths considered high number establishes hepatitis important priority
background work demands critical care major cause stress intensive care unit icu professionals lead poor health outcomes process recovery work psychological rumination considered important mediating variable relationship work demands health outcomes study aimed extend knowledge process icu stressors differing rumination styles associated burnout depression risk psychiatric morbidity among icu professionals methods ninety six healthcare professionals doctors nurses work icus completed questionnaire icu related stressors burnout work related rumination depression risk psychiatric morbidity results significant associations icu stressors affective rumination burnout depression risk psychiatric morbidity found longer working hours also related increased icu stressors affective rumination problem solving pondering distraction detachment mediated relationship icu stressors burnout depression risk psychiatric morbidity increased icu stressors greater affective rumination associated greater burnout depression risk psychiatric morbidity moderating effects observed conclusions longer working hours associated increased icu stressors increased icu stressors conferred greater burnout depression risk psychiatric morbidity via increased affective rumination importance screening healthcare practitioners within intensive care depression burnout psychiatric morbidity highlighted future research evaluate psychological interventions target rumination style could made available highest risk efficacy cost effectiveness delivering interventions also considered
forward army bases high ambient temperature grid locations require power cooling capacity function properly due inefficient existing configuration meet demands safety stability issues liter fuel consumed electrical power must first pass complex hostile network place conventional configuration composed genset electrical generator set electrically powered vcs vapor compression system utilizing smaller genset waste heat driven libr lithium bromide water absorption system provides efficient chp combined heat power configuration design criteria ambient temperatures degrees providing non cooling electricity cooling two configurations simulated steady state transient conditions additionally proposed avoid crystallization air cooled heat exchangers unlike conventional crystallize high ambient temperatures bulky cooling towers transient simulation hottest week results showed fuel savings chp configuration elsevier ltd rights reserved
background aim study compare multidisciplinary approach menstrual related migraine combining neurological gynaecological consultation mono disciplinary approach involving neurological treatment clear relationship menstruation cycle occurrence migraine menstrual migraine nowadays treatment menstrual related migraine performed neurologist treatment attention hormonal treatment seems convenient methods retrospective study performed cohort using data women menstrual related migraine visited menstrual migraine clinic intervention group results compared historical control group consisted women menstrual related migraine treated received mono disciplinary approach results intervention group headache impact hit score significantly improved points mean headache days per month declined significantly days women needed less use pain medication control group decline hit score less striking points mean headache days per month increased days appeared patients control group required gynaecological consultation course time conclusion multidisicplinary treatment women menstrual related migraine gives better results compared mono disciplinary approach results interpreted caution performed retrospective study relative small control group
background surgical procedures patients high risk developing venous thromboembolism clinically manifested deep vein thrombosis dvt pulmonary embolism objective evaluate influence polypharmacotherapy comorbidity drug treatments packed red blood cells application adequacy thromboprophylaxis patient characteristics occurrence dvt postsurgical patients setting surgical department murska sobota general hospital slovenia methods retrospective case control study records surgical patients analysed dvt group control group number prescribed drugs drug drug interactions reviewed together prescription low molecular weight heparins odds ratios risk factors dvt calculated using multivariable logistic regression model main outcome measure risk factors assessment occurrence dvt surgical patients results polypharmacotherapy packed red blood cells application associated increased risk dvt surgery inadequate thromboprophylaxis low molecular weight heparins significantly increased likelihood dvt differences groups concerning treatment nonsteroidal anti inflammatory drugs benzodiazepines antipsychotics conclusions patients polypharmacotherapy patients receiving red blood cells monitored closely surgery likely develop dvt
children adhd often show symptoms oppositional defiant disorders odd investigated impact adjuvant risperidone risp standard treatment methylphenidate mph children adhd symptoms odd eighty four children adhd odd age range years males took part double blind randomized placebo controlled clinical trial lasting eight weeks participants randomly assigned either mph risp mph plco placebo condition symptoms adhd weight height blood pressure assessed baseline weeks symptoms adhd decreased time mph risp mph condition mph risp condition weight waist circumference prolactine levels increased time data suggest adjuvant risp improved symptoms children adhd odd weight gain higher prolactine levels also observed two alarming side effects may become issue children become adolescents period life body shape body self image closely linked self confidence peer acceptance health care professionals carefully balance short term long term costs benefits administration risp
edge preserving weighted median filtering fundamental operator great variety image processing computer graphics applications paper presents novel real time weighted median filter effectively smoothes high frequency details preserving major edges propose edge aware data structure dimensional bilateral grid extending dimensional bilateral grid additional range dimension edge aware weights weighted median values computed dimensional space proposed algorithm highly parallel enabling real time gpu based implementation experimental results show filter run real time modern gpus variety edge aware applications including detail enhancement inverse halftoning jpeg artifact removal image stylization photographic look transfer image colorization demonstrated verify feasibility proposed weighted median filter elsevier ltd rights reserved
lateral septum brain structure implicated addictive behaviours regulates activation dopaminergic neurones ventral tegmental area vasopressinergic projections extended amygdala sexually dimorphic could responsible vulnerability addiction sex dependent manner present study aimed investigate modulatory effects amphetamine amph expression vasopressin avp vasopressinergic extra hypothalamic system sensitised male female rats adult male female sprague dawley rats underwent amph locomotor sensitisation protocol acute amph increased avp mrna expression medial amygdala mea whereas amph induced sensitisation increased avp mrna expression bed nucleus stria terminalis bnst females interestingly increase avp expression bnst higher oestrus females compared dioestrus females acute amph resulted decrease avp levels males thus complex region specific interactions amph extra hypothalamic vasopressinergic system brain underlying possible alterations different behaviours caused acute chronic amph exposure
introduction india higher prevalence prediabetes diabetes hypothyroidism subclinical hypothyroidism prevalent females males studies shown elevated hbac non diabetic hypothyroid patients defined normal serum triiodothyronine thyroxine levels serum thyroid stimulating hormone tsh level falling aim study hbac level non diabetic subclinical hypothyroid patients compare hbac level controls materials methods case control study conducted subjects total subjects subclinical hypothyroidism without diabetes selected basis serum tsh fasting blood sugar fbs level another age sex matched normal healthy individuals selected control hbac levels measured using immunoturbidimetry method cobas integra plus independent test applied find statistically significant difference level hbac case control groups results subjects non diabetic subclinical hypothyroidism significant higher level hbac controls significant difference cases controls age sex fbs vitamin haemoglobin serum serum levels conclusion data suggest non diabetic subjects subclinical hypothyroidism show misleadingly high levels hbac therefore effect altered levels serum tsh hbac must considered interpreting hbac diagnosis diabetes subclinical hypothyroid patients
prior epidemiological study identified reduction opioid overdose deaths states legalized medical cannabis one theory explain phenomenon potential substitution effect opioids study evaluated whether substitution effect opioids also applies psychoactive medications new england dispensary members completed online survey medical history experiences among respondents regularly used opioids three quarters indicated reduced use since started significantly greater patients reduced use antidepressants alcohol approximately two thirds patients decreased use anti anxiety migraine sleep medications following significantly exceeded reduction antidepressants alcohol use patient spouse family friends likely know use primary care provider conclusion majority patients reported using less opioids well fewer medications treat anxiety migraines sleep initiating smaller portion used less antidepressants alcohol additional research needed corroborate self reported retrospective cross sectional findings using data sources
backgroundthe role fibrocytes chronic obstructive pulmonary disease copd unknown sought enumerate blood tissue fibrocytes copd determine association blood fibrocytes clinical features disease methodsutilizing flow cytometry identify circulating collagen type cells found two populations fibrocytes myeloid derived suppressor cell mdsc like fibrocytes cells stable copd control subjects lung resection material separate group subjects without copd collected tissue fibrocyte detection examined circulating fibrocyte populations correlations clinical parameters including quantitative computed tomography qct determined pathways association correlated variables using path analysis model resultsblood tissue fibrocytes increased compared control subjects blood fibrocytes associated lung function qct increased eosinophilic copd myeloid derived suppressor cell like fibrocytes increased copd compared controls path analysis model showed collagen type intensity mdsc like fibrocytes positively associated lung function associations air trapping predominately upper lobes conclusionwe demonstrated two circulating populations fibrocyte exist copd distinct clinical associations prevalent proximal small airway tissue blood mdsc like fibrocytes however increased associated preserved lung function small airway dependent mechanism copd
objectives study aimed assess effect microablative fractional laser laser therapy vaginal pathophysiology symptoms genitourinary syndrome menopause gsm methods postmenopausal women moderate severe symptoms gsm underwent three sessions laser therapy monthly intervals participants evaluated baseline weeks last treatment main outcome measures primary outcomes vaginal maturation value vmv vaginal health index score vhis secondary outcomes included symptoms gsm female sexual function index fsfi international consultation incontinence questionnaire female urinary tract symptoms iciq fluts urinary incontinence short form iciq urogenital distress inventory udi king health questionnaire khq results fifty three postmenopausal women completed study vmv vhis fsfi increased significantly dyspareunia dryness burning itching dysuria frequency urgency urgency incontinence stress incontinence scores iciq fluts iciq udi khq decreased significantly factors predicting women laser therapy effective identified conclusion study suggests intravaginal laser therapy postmenopausal women clinical signs symptoms gsm may effective improving vaginal pathophysiology reported symptoms elsevier ireland ltd rights reserved
study examined role mood congruency retention interval false recognition emotion laden items using deese roediger mcdermott drm paradigm previous research shown mood congruent false memory enhancement immediate recognition tasks present study examined persistence effect following one week delay participants placed negative neutral mood presented negative emotion neutral emotion drm word lists administered immediate delayed recognition tests results showed negative mood state increased remember judgments negative emotion critical lures comparison neutral emotion critical lures immediate delayed testing findings discussed relation theories spreading activation emotion enhanced memory consideration applied forensic implications findings
shape human pelvis reflects unique demands placed hip abductor muscles gluteus medius gluteus minimus stabilize body frontal plane bipedal locomotion morphological shift occurred early hominin evolution yet important shape differences hominin species led significant disagreement abductor function locomotor capability extinct taxa static biomechanical model relies close association skeletal measurements pelvis femur traditionally used reconstruct hip biomechanics species however experimental biomechanical approaches highlighted dynamic nature mediolateral balance walking running challenging assumptions static hip model article reviews traditional approaches understanding hip abductor function shows applied fossil hominin record discusses new techniques integrate dynamic nature mediolateral balance human locomotion wiley periodicals inc
cinema massively produced widely disseminated format twentieth twenty first centuries violent dialogue public discourse scholarship regarding cinematic representation violence paper approaches film violence marxist framework propose philosophy karl marx reveals critical insight regarding relationship cinema violence capital particular essay scrutinizes commercial narrative cinema thus approaches cinema hegemony violence cinema considered role reproducing social organization capitalism namely hierarchical relationship ruling ruled classes cinema historically used violence narrative spectacle propagate relations production ontology capitalism consists cartesian subjectivity vertical orientation towards words violent cinema crucial subject capitalism shares pivotal function perpetuating class antagonism cinema must constantly mediate violence capital simultaneously obfuscating also maintaining violent cinema like proletariat also holds emancipatory potential critique eventual dismantling
paper presents novel approach reduce post processing numerical weather prediction nwp grid models extract solar irradiance predictions sub grid locations technique estimates solar irradiance observations nwp model using novel bank kalman filters kfs operate tandem accurately predict solar irradiance hours ahead desired node point campus based photovoltaic solar energy resource cork institute technology cit nwp model outputs irradiance values cork airport cit bank acting post processing tool moving time averaging window derives hour look ahead irradiance schedule cit applying polynomial map filter irradiance bias offset two grid points order polynomial irradiance model employed bank state estimator point average used smoothing error state measurement covariance matrices procedure accurately predicts irradiance significant reduction root mean square error rmse existing methods site specific location manipulation nwp grid model output fixed grid points since many system operators use day ahead commitment electricity generators meet next day forecasted load demand accuracy hour look ahead irradiance estimates crucial electricity power generation strategic importance installed solar scheduling issue cost effective electrical network operation consequent beneficial economic return solar array installation capital investment moving closer real time updated conditions forecasts used dispatch generators secure energy reserves lock electric energy imports exports
background cerebrospinal fluid csf opening pressure considered diagnostic criterion pseudotumor cerebri syndrome ptcs children however proposed diagnosis probable ptcs made seven children mri findings supportive ptcs seen eight patients conclusions diagnosis probable ptcs subgroup ptcs convincingly made children results opening pressure measurement always need interpreted within whole clinical context treatment decisions patients probable ptcs follow stage based principles proven ptcs european paediatric neurology society published elsevier ltd rights reserved
half new lung cancer diagnoses made patients locally advanced metastatic disease point therapeutic options scarce anticipated however widespread use low dose computed tomography ldct screening lead greater proportion lung cancers diagnosed early operable stage still overall rate recurrence surgically treated stage lung cancer patients within years diagnosis thus identification clinical application biomarkers early stage lung cancer pressing medical need integrative analysis omic clinical epidemiological data single patients core principle precision medicine rigorous bioinformatics statistical analyses identified biomarkers early stage lung cancer based dna methylation expression mrna mirna inflammatory cytokines urinary metabolites beyond comprehensive understanding molecular taxonomy lung cancer biomarkers practical implications context unmet clinical needs early stage lung cancer patients first current guidelines ldct screening broadly include individuals based age history heavy smoking tumor derived circulating biomarkers blood urine associated lung cancer risk could narrow prioritize individuals ldct screening second high number nodules identified ldct fewer finally diagnosed lung cancer biomarkers may help discriminate malignant nodules benign indolent lesions third expected rise numbers lung cancer patients diagnosed early stage necessitate new treatment options circulating urinary tissue based biomarkers molecularly categorize stage patients tumor resection help identify high risk patients may benefit adjuvant chemotherapy innovative immunotherapy regimens published elsevier ireland ltd
monitoring urban expansion dynamically using remote sensing technology essential method obtaining understanding urban spatial structure however quality traditional optical images areas poor due clouds fog compared optical images synthetic aperture radar sar achieve earth observations without limits sunlight weather conditions speckle obvious paper combined advantages pixel level optical image sar image time series proposed spatiotemporal fuzzy clustering stfc strategy urban expansion monitoring strategy includes three parts construction optical sar image mixed time series time series fuzzy information granulation method ascertain change nodes stfc determine change types range study images sar scenes taken selected raw data used proposed method monitor urban expansion chengdu china analyzed main causes according monitoring results results suggested proposed methods could effectively extract change nodes change pixels correctness completeness outperforming time series nonspatial fuzzy clustering method well traditional classification methods urban expansion chengdu apparent expansion direction shifting traditional ring structure expansion point axis expansion following priority given construction new urban areas
objectives women physical mental ill health shows marked increase menopause usually occurs years age mental illness somatic symptoms common causes long term sick leave women suffer lack knowledge menopause transition associated symptoms aim study investigate whether group education women primary health care phc menopause transition improve physical mental ill health study design randomized controlled study conducted phc aimed evaluate group education programme women aged years around menopause transition total women randomized group education intervention group intervention included two education sessions topics related menopause answered two questionnaires baseline four month follow menopause rating scale mrs montgomery asberg depression rating scale madrs main outcome measure change mrs madrs scores four months results intervention group experienced slight reduction symptoms control group mostly experienced opposite conclusion study showed feasible implement group education menopause women aged years clinical trial registration number ntco elsevier rights reserved
interprofessional education ipe continues gain traction worldwide challenges integrating ipe health profession programmes include finding convenient times meeting spaces level appropriate assignments profession article describes implementation month prospective cohort study pilot programme master science nursing family nurse practitioner fnp doctor pharmacy pharmd students private university united states ipe experience utilised blended approach learning activities students initial final sessions met face face asynchronous online activities two sessions online assignments discussions quizzes pilot programme involved topics antimicrobial stewardship hormone replacement therapy human papilloma virus vaccination prenatal counselling emergency contraception effects affordable care act practice results suggested fnp students held favourable attitudes online ipe pharmd students reported clearer understanding roles participating healthcare students however students also reported wanting face face interaction online ipe experience implications study suggest effective online ipe supported ensuring educational parity students regarding various topics discussed consistent approach required involvement student groups needed addition given students desire face face interaction may beneficial offer online ipe activities shorter time period anticipated study may inform programmes exploring innovative approaches provide ipe promote effective collaboration patient care
detection ddos distributed denial service traffic great importance availability protection services information communication resources research presented paper shows application artificial neural networks development detection classification model three types ddos attacks legitimate network traffic simulation results developed model showed accuracy classification pre defined classes traffic
people psychopathology experience high rates smoking trouble quitting minnesota multiphasic personality inventory restructured form mmpi tellegen ben porath valid reliable instrument assessment psychopathology study examined ability mmpi assess psychopathology predict smoking cessation outcomes sample smokers seeking psychological treatment stop smoking end treatment month follow ups results showed scores neurological complaints nuc scale associated higher likelihood smoking month follow controlling effect age initial levels nicotine dependence results highlight usefulness mmpi field smoking cessation treatment elsevier ltd rights reserved
international literature studied role parental eating disorder children development highlighting constitutes relevant risk factor onset offspring emotional behavioural problems limited attention given parental binge eating disorder bed impact offspring psychopathology thus investigations clinical manifestation possible predictor offspring psychopathology needed present study aimed assess maladaptive outcomes children parents psychopathological risk psychiatric diagnoses specifically intended verify whether offspring parents diagnosed bed showed higher affective behavioural problems compared peers one parent diagnosed bed conducted longitudinal study months old children months old children sample italian couple parents children total divided three groups based presence bed diagnosis group diagnosis parents group diagnosis mothers group diagnosis fathers presence bed one parents associated emotional behavioural development offspring particularly diagnosis bed parents direct effect infants affective problems offspring parents diagnosed bed likely manifest emotional behavioural difficulties psychiatric symptoms within first three years life published future academy
estrogen deficiency associated menopause accompanied increase rate bone remodeling appearance remodeling imbalance greater number remodeling transactions deposits less bone resorbed resulting microstructural deterioration newly deposited bone also less completely mineralized older bone resorbed examined whether breastfeeding estrogen deficient state compromises bone microstructure matrix mineral density distal tibial distal radial microarchitecture quantified using high resolution peripheral quantitative computed tomography women breastfeeding controls follow years five months exclusive breastfeeding increased cortical porosity confidence interval reduced matrix mineralization density reduced trabecular number per increased trabecular separation relative prebreastfeeding median years range cessation breastfeeding cortical porosity remained higher matrix mineralization density remained lower trabeculae fewer greatly separated deficits greater controls results similar distal radius bone microstructure may irreversibly deteriorated cessation breastfeeding appendicular sites studies needed establish whether deterioration compromises bone strength increases fracture risk later life american society bone mineral research
background aimreplantation avulsed teeth may lead root resorption bisphosphonates bps class drugs used treat resorptive diseases bone osteoporosis paget disease observed exert antiresorptive effect periodontal bone well antiresorptive properties bps could prove useful preventing root resorption replanted avulsed teeth aim systematic review analyze summarize currently available literature concerning use bps preventing root resorption avulsed teeth materials methodspubmed medline google scholar isi web knowledge embase databases searched using keywords bisphosphonate replantation tooth quality assessment study carried addition general characteristics outcomes study summarized resultsafter exclusion irrelevant articles animal studies included review majority studies suggest surface application zoledronate alendronate reduces root resorption replanted teeth animal models surface treatment etidronate significant effect root resorption intracanal etidronate accelerated resorption conclusionsurface application zoledronate alendronate reduces root resorption replanted teeth animal models however efficacy intracanal usage bps still debatable
purpose objective study analyze effect size intervention studies posttraumatic growth patients cancer methods total studies published identified searching ovid medline cinahl pubmed scopus psycarticles cochrane library riss kiss studies selected inclusion meta analysis data analyzed using comprehensive meta analysis cma ver program effect sizes shown using hedges score results intervention studies included studies cognitive behavioral stress management cbsm studies mindfulness based stress reduction mbsr studies couple based intervention study health coaching building resilience yoga painting intervention overall controlled effect size using fixed effects model effective intervention couple based intervention followed mbsr cbsm conclusion cancer one significant traumatic events affect patients lives cancer patients known posttraumatic growth therefore necessary consider nursing interventions increase posttraumatic growth cancer patients couple based intervention mbsr cbsm
hemingway entire oeuvre many biographical examinations life read terms tension love work although much written sexuality androgyny gender identification hemingway fiction theme work relationship work romance largely neglected essay focuses two novels center protagonists work bell tolls garden eden suggests dynamics male female relationships work essential understanding hemingway imagination male artist essay investigates protagonists devote work explains relationship protagonists love interests work helps define work novels differs cases art substantiates protagonists masculinity part forming meaningful lasting connections people true even case robert jordan whose art destruction design exploring ironies work hemingway shows artist must separate closest order execute work work inspire others garden eden received great deal critical attention due undermining traditional gender roles reading novel alongside bell tolls suggests characterizes hemingway depiction male artist showing importance relationships humanistic pursuit
background immigration south korea neighboring asian countries risen dramatically primarily due marriage korean men foreign women although filipino women rank fourth among married immigrant women little known health condition population manuscript focuses design methods filipino women diet health study filwhel subjects methods filwhel cohort filipino women married korean men aged years old data collection comprised three parts questionnaire physical examination biospecimen collection questionnaires focused demographic factors diet health related behaviors acculturation immigration related factors medical history quality life children health information participants visited recruitment site answered structured questionnaires face face interview also measured anthropometric features collected fasting blood samples toenails dna samples recruitment started results conclusions collection data ongoing plan prospectively follow cohort participants expect study focused married filipino women immigrants elucidate nutritional health status effects transitional experiences several lifestyle factors
changes construction projects always going happen avoided changes causes disruption performance construction projects especially time cost performance many factors cause changes construction projects one influential factor design change study examines influential affect design changes construction projects influential factors design changes classified two groups internal factors consist owner design consultant construction management consultant contractor external factors involve political economic natural environment advance technology third party research method employed questionnaire survey consisting questions occurrence design changes construction projects distributed managers construction project data analyzed using partial least square pls finding shows owner greatest influential factors occurrence design changes subsequent factors design consultant construction management consultant political economic natural environment contractors third parties advance technology indicated values loading factor respectively finding provide useful information practitioners reduce occurrence design changes construction projects well improve performance construction projects authors published elsevier ltd
glass systems composition mol mol mol mol mol prepared using normal melt quench technique mossbauer effect used intensively help investigate structure bonding oxide glasses mossbauer spectra indicate presence iron iron iii tetrahedral octahedral coordination dependence electrical data analyzed frame work impedance cole cole plot frequency range mhz room temperature constant phase elements cpe used equivalent electrical circuits fitting experimental impedance data frequency dependence electric conductivity found follow simple power law behavior accordance relation sigma sigma smaller thermal activation energies electronic conduction estimated basis arrhenius plots published elsevier
background previous years substantial number studies identified statistically important predictors nursing home admission nha however far know analyses done population level prior research analysed prediction accuracy nha model individuals methods study analysis longer term home care customers city tampere finland data collected records social health service usage rai resident assessment instrument home care assessment system january september aim find efficient variable subsets predict nha individuals validate accuracy variable subsets predicting nha searched sequential forward selection sfs method variable ranking metric classifiers logistic regression support vector machine svm gaussian naive bayes gnb validation results guaranteed using randomly balanced data sets cross validation primary performance metrics classifiers prediction accuracy auc average area curve results gnb classifiers achieved accuracy predicting nha important variables rai maple method assigning priority levels functional impairment rai iadl activities daily living cognitive impairment rai cps cognitive performance scale memory disorders diagnoses use community based health service prior hospital use emergency visits periods care conclusion accuracy classifier individuals high enough convince officials city tampere integrate predictive model based findings study part home care information system work need done evaluate variables modifiable responsive interventions
people often misremember past consistent present recent research using induced compliance paradigm revealed cognitive dissonance one mechanism underlie memory distortion sought replicate extend finding using free choice paradigm participants made either easy difficult choice two smartphones either immediately two days later reported memories decision experience participants made difficult decision produced spread alternatives effect expected dissonance theory also likely easy conditions misremember initial decision favourably initially rated overall findings replicate effect dissonance memory distortion show effect generalises dissonance inducing situations
background identification subgroups patients different levels sensitization clinical features help identify groups risk development better therapeutic strategies aim study identify subgroups patients tension type headache tth different levels sensitization clinical pain features psychological outcomes methods total individuals tth participated headache intensity frequency duration medication intake collected weeks diary pressure pain thresholds assessed bilaterally temporalis muscle joint second metacarpal tibialis anterior muscle determine widespread pressure pain hyperalgesia hospital anxiety depression scale assessed anxiety depression state trait anxiety inventory evaluated state trait levels anxiety headache disability inventory evaluated burden headache health related quality life determined questionnaire groups considered positive three criteria negative less three criteria clinical prediction rule headache duration day headache frequency days week bodily pain vitality results ancova revealed subjects group positive rule exhibited longer headache history shorter headache duration lower headache frequency higher widespread pressure hyperalgesia higher anxiety trait levels lower quality life subjects within group negative rule differences similar men women conclusions study identified subgroup patients tth higher sensitization higher chronicity headaches worse quality life lower frequency duration headache episodes subgroup individuals tth may need particular attention specific therapeutic programs avoiding potential chronification
cyber physical systems result integration information communication technologies physical systems particular case cyber physical power systems use communication technologies perform real time monitoring operations impacting systems characteristics reliability addition known failures communication network relevant electrical network failures terms cyber physical power distribution systems cppds reliability however operators performances response time decision quality cppds contingencies investigated yet study authors introduce model operator response time present sequential monte carlo simulation methodology incorporates response time cppds reliability indices estimation evaluate impact response time cppds reliability indices method tested cppds using different values operators average response time results show operators response time affects reliability indices related failures duration indicating fast decision directly contributes system performance authors conclude improvement cppds reliability dependent electric communication components also dependent operators performance
paper summarizes main characteristics differences influence mechanical laser cutting magnetic properties electrical steel sheets quasi static measurements well measurements higher frequencies reported three different ferromagnetic materials commonly used electric machines subsequently method consider effect cutting modeling process reviewed method based measurement data obtained standardized wide spread fast perform epstein frame method eliminates need knowing exact deterioration depth applicable different cutting techniques
background wilson disease rare autosomal recessive inherited disorder caused mutation copper transporting gene atpb affecting liver nervous system patients may initially present psychiatric symptoms diagnosis difficult establish objectives present preliminary study evaluate relevance serum copper ceruloplasmin measures hospitalized patients psychiatric disorders identify possible mutations atpb gene patients abnormal biological copper profile methods psychiatric patients participated study hospitalized saint jean dieu hospital lyon france measured immunoturbidimetry serum inductively coupled plasma optical emission spectrometry serum levels inferior respectively combination atypical psychiatric presentations complete clinical examinations performed multidisciplinary physicians specialized addition mutation detection atpb gene performed results total patients completed study cases showed decreased concentrations molecular genetic tests performed patients one atpb mutation heterozygous state found four patients identified three different missense mutations hisgln exon proser exon thrmet exon pathogenic mutation either atpb allele detected conclusion results serum concentrations normal limits common patients psychiatric disorders nonrelevant informative diagnosis diagnosis based combination clinical biological arguments psychiatric patients suspicion evaluated reference center
epidemiological studies adolescents eating disorders demonstrate high prevalence disordered eating behaviors higher prevalence eating disorders among girls several studies recently demonstrated association female adolescents eating disorders parental psychopathological risk impaired family functioning poor quality relationships among family members basis premises conducted cross sectional study initially recruiting families female adolescents affected anorexia nervosa group bulimia nervosa group binge eating disorder group average age assess psychological profile scl specific representations family functioning faces possible effect adolescents psychological profiles parents psychopathological risk family functioning results indicate adolescents parents groups show unequivocal psychopathological profile particular adolescents anorexia present severe psychopathological risk results show adolescents parents differ perception family functioning specifically adolescents anorexia perceive family highly disengaged poorly interwoven rigid addition cohesion communication qualities perceived low interestingly parental psychopathological risk predicts adolescents specific perception family functioning findings may guide clinical interventions suggest distinct maternal psychopathological symptoms associated variety clinical configurations offspring whereas paternal psychopathological risk may present adolescents suffering forms eating disorders
background restricting access lethal means well established strategy suicide prevention however hypothesis subsequent method substitution remains difficult verify case jumping high places hotspots studies unable control potential shift suicide locations investigation aims evaluate short long term effect safety barriers brisbane gateway bridge examine whether substitution suicide location methods data suicide jumping brisbane australia obtained queensland suicide register effects barrier installation gateway bridge assessed natural experiment setting descriptive poisson regression analyses used results suicides jumping brisbane identified almost half occurred gateway story bridges installation barriers gateway bridge number suicides site dropped period reduction found subsequent years analyses confirmed evidence displacement neighbouring suicide hotspot story bridge locations conclusions safety barriers effective preventing suicide gateway bridge evidence substitution location found
role cerebellum pathologies trigeminal nervous system still unknown although recently gathered evidence point modulatory rather passive role provide evidence activation specific cerebellar areas nociceptive trigeminal input left nostril large number volunteers subjects additional independent group subjects measured functional magnetic resonance imaging fmri peak voxel activity ipsilateral stimulated side seen cerebellar lobules villa crus vermal lobule viiia although activations also seen contralateral side individuals intensity unpleasantness ratings mostly processed hemispheric lobules stretching representing face areas cerebellar fractured homunculus found robust functional connectivity nociception cerebellum rostral part pons well periaqueductal grey thalamus involving descending antinociceptive network well areas known form close loops cerebellum motor domain cerebellar connectivity higher cortical areas include known hubs pain processing insular cortex operculum putamen face areas precentral gyrus current data provide solid basis research cerebellar activity connectivity primary headache facial pain syndromes
systemic administration opioids leads potentially severe undesirable side effects like sedation drowsiness vomiting nausea allergies respiratory depression neutrophil dysfunction application nanotechnology medical field drawn great attention recent times several treatments available tedious expensive application nanotechnology brings faster cure cost effectiveness nanoliposomes one widely used names nanoparticles used medicine recently nanoliposomes used crucial novel drug delivery systems use nanoliposomal formulation brings good results pain control rapid patient recovery increased patient comfort treatment costs reduction shortens length hospitalization review presents brief description achievements field nanoscience nanotechnology related application nanoliposomes anesthesia published elsevier masson sas
estimation parameters chaotic systems subject substantial well developed research issue nonlinear science viewpoint optimization parameter estimation formulated multi modal constrained optimization problem multiple decision variables investigation makes systematic examination feasibility applying newly proposed population based optimization method labeled teaching learning based optimization tlbo identify unknown parameters class chaotic system preliminary test demonstrates despite global fast coarse search capability teaching learning based optimization often risks getting prematurely stuck local optima enhance fine local searching performance tlbo nelder mead simplex algorithm based local improvement incorporated tlbo continually search global optima reflection expansion contraction shrink operators working well established lorenz system assess effectiveness efficiency proposed improved tlbo strategy empirical results indicate success proposed hybrid approach global exploration local exploitation well balanced providing best solutions instances used state art metaheuristics chaotic identification literature including particle swarm optimization genetic algorithm quantum inspired evolutionary algorithm
study investigated participant reactions hate crime versus nonbiased crime incident reports included less detail crime using victim race african american unstated amount information vague detailed subjects factorial design hypothesized participants would sympathetic distressed blame victim less victim african american designating hate crime detail included incident report results generally showed greater psychological impact hate crime versus nonbiased crime information presented vague information two manipulations interact influencing participants reactions results indicate amount detail provided crime considered publishing incident reports
image contrast enhancement algorithms play crucial role image processing computer vision main challenge contrast enhancement algorithm suitable low contrast distorted images suit high contrast distorted images paper efficient contrast enhancement algorithm automated parameterization proposed using concept genetic algorithm fuzzy intensification operator main focus proposed method improve visibility information image manipulating intensity information simulation results proposed fuzzy genetic based method compared standard existing methods log gamma linear contrast stretching histogram equalization adaptive histogram equalization rule based fuzzy method using default parameter values performance proposed existing methods low low moderate high high levels contrast distorted images quantitatively measured using peak signal noise ratio psnr structural similarity index measure ssim feature similarity index measure fsim psnr ssim fsim values statistically analysed two way anova results experiment inferred contrast enhancement techniques performed well level distortions low moderate contrast enhancement better proposed fuzzy genetic based method existing methods overall proposed fuzzy genetic based method performed well low high levels distorted images higher psnr ssim fsim values existing methods
study question exposure menopausal hormone therapy mht mid aged women alter risk cardiovascular disease cvd mortality cause mortality summary answer mht soon menopause unlikely increase risk cvd mortality cause mortality may protective effect women hysterectomy oophorectomy known already balance benefits risks mht currently unclear may differ according treatment starts whether women intact uterus study design size duration total participants mid aged population based cohort born australian longitudinal study women health alswh followed participants materials setting methods measures included cardiovascular cause mortality exposure mht menopausal status based yearly self reports electronic prescriptions data mht also available mid onwards follow survey wave participants classified existing user mht initiator mht non initiator mht main results role chance adjusting confounding variables existing users mht reduced risk hazard ratio cvd mortality compared non initiators insufficient evidence association identified initiators mht cause mortality risks reduced initiators existing users subgroup analysis women hysterectomy oophorectomy lower risks cvd mortality initiators existing users evidence association found women whose mht commenced menopause similarly cause mortality women hysterectomy oophorectomy lower risks initiators existing users limitations reasons caution limitations include observational nature study small number deaths mht use self reported classification menopausal status also based self reported information study funding competing interest women considering mht soon menopause reassured treatment unlikely increase risk cvd mortality cause mortality study funding competing interest australian longitudinal study women health funded australian department health funded australian research council future fellowship funded china scholarship council csc graduate scholarship authors report conflict interest trial registration number
low efficiency levels lack integration processes project participants long significant problems construction building information modeling bim solution problems however bim implementation free risks challenges study investigates critical success factors csfs bim implementation developing countries bim fairly new construction industry respect questionnaire survey designed administered public private sector participants turkey ninety six respondents provided valid responses questionnaire forms sent based collected data relative importance csfs bim implementation examined results statistical analysis reveal three important factors availability qualified staff effective leadership availability information technology factor analysis also employed data results indicate underlying factors csfs human related industry related project related policy related resource related factors besides csfs analyzed based various project organizational characteristics findings study expected provide better understanding essential elements bim implementation guide industry practitioners developing proper strategies effective management implementation process
background angioedema potentially life threatening condition hereditary hae acquired aae iatrogenic causes careful workup allows identification etiology attacks appropriate management cohort study based clinical practice setting aimed investigating clinical laboratory findings concerning different features patients recurrent referred single tertiary level center hae methods clinical laboratory data patients fulfilling criteria inhibitor deficient hae inh hae inhaae angiotensin converting enzyme inhibitor related acei idiopathic aae aae evaluated descriptive statistics analyzed means mann whitney test fisher exact test used group comparisons results patients diagnosed type hae type hae inh aae acei aae included patients concomitant autoimmune diseases aae group aut aae age disease onset diagnosis younger type hae groups diagnostic delay longer type hae acei levels lower inh aae type hae acei aut laae hae inh aae showed lower inh antigen function compared groups peripheral attacks frequent type hae airway abdominal oral attacks prevalent inh aae conclusion investigating clinical laboratory features recurrent without wheals represents major topic facilitating early diagnosis improving treatment strategies heterogeneous misdiagnosed condition karger basel
electrical variable frequency drive vfd device controls motor varying frequency voltage supplied motor frequency hertz directly related motor speed rpms application require electric motor run full speed vfd used ramp frequency voltage meet requirements electric motor load application motor speed requirements change vfd simply turn motor speed meet speed requirement turn controls output connected equipment case pipeline pump flow pressure device important pipeline applications provides operator improved control critical parameters pump increases pumping efficiency reducing energy costs enbridge liquids pipelines gradually introduced vfd units mainline pumping systems since date mainline pumps enbridge liquids pipeline network operate control vfd sufficient historical operating data assets order quantify benefits related particular system paper focuses operational reliability aspects vfds equipment controlled vfd includes failure probabilities throughput performance life cycle system excludes technical implications vfd selection application specification design pure maintenance perspective vfds contribute marked improvement pumps terms failure reduction general pump failures including components mechanical seals bearings shaft wear rings couplings demonstrated probability failure lower pumps combined vfds compared pumps without vfds terms mean time repairs mtbr equates increase relative pumps vfds mainline pumps enbridge driven electric motors regards drive motor failures also significant reduction repairs mtbr increases approximately vfd driven electric motors another factor enhance benefits associated vfds sparing options enbridge liquids pipelines two types sparing options related vfds dedicated vfds vfd controlling single mainline pump shared vfd vfd shared set mainline pumps back across line starting throughput performance mentioned existing options shown differ substantially specific pipeline built initially shared vfds fitted dedicated vfds number pump failures decreased leading throughput loss reduction however vfd helps preserve asset runs conjunction vfd introduces high frequency failures overall pumping system systems studied enbridge pipelines adding vfd increases frequency downtime events however failures short duration long term add less downtime less pumping system vfd finally vfd units high capital cost double cost ownership pumping system life cycle asset however cost offset increase availability provide vfd needs vetted life cycle cost analysis
anti fat bias professors physical education departments may interfere training provided pre service teachers purpose study evaluate attitudes professors physical education departments toward obese individuals professors randomly selected institutions across four regions participated study participants took implicit association test answered anti fat attitude scale two questions specifically designed measure attitudes toward physical education teachers majors obese participants exhibited implicit good bad lazy motivated anti fat biases professors favored accepting majors obese strongly disapproved obese physical education teachers role models students explicit anti fat bias associated stronger disapproval physical education teachers obese role models students accepting majors obese implicit good bad anti fat bias associated stronger disapproval obese physical education teachers role models students anti fat bias demonstrated professors may negatively affect training pre service physical education teachers work students body sizes awareness programs may necessary diminish anti fat bias among professors physical education teacher education programs
measures psychopathy proved valuable risk assessment violent criminals however neuronal basis psychopathy contribution prediction criminal recidivism still poorly understood compared structural imaging data male high risk violent offenders non delinquent healthy controls via voxel based morphometry psychopathic traits risk violence recidivism correlated gray matter volume gmv regions interest previously shown relevant criminal behavior relative controls criminals showed less gmv prefrontal cortex pfc gmv cerebellar regions basal ganglia structures within criminals found negative correlation prefrontal gmv psychopathy additionally positive correlation cerebellar gmv psychopathy well risk recidivism violence moreover gmvs basal ganglia supplementary motor area sma positively correlated anti sociality gmv amygdala negatively correlated dynamic risk violence recidivism contrast gmv para limbic areas orbitofrontal cortex insula positively correlated anti sociality risk violence recidivism current investigation revealed violent offenders deviations gmv pfc well areas involved motor component impulse control cerebellum basal ganglia sma differentially related psychopathic traits risk violence recidivism results might valuable improving existing risk assessment tools ibro published elsevier ltd rights reserved
obesity increasingly recognized major modifiable determinant atrial fibrillation although body mass index clinical measures useful indications general adiposity much recent interest focused epicardial fat distinct adipose tissue depot readily assessed using non invasive imaging techniques growing body data epidemiological clinical studies demonstrated epicardial fat consistently associated presence severity recurrence across range clinical settings evidence basic science translational studies also suggested arrhythmogenic mechanisms may involve adipocyte infiltration pro fibrotic pro inflammatory paracrine effects oxidative stress pathways despite advances however significant uncertainty exists many questions remain unanswered article review present understanding epicardial fat including classification quantification existing evidence implicating role potential mechanisms implications clinicians future directions research
research integrates self determination theory social identity approach investigate notion collective group level self determination test agent intergroup help helping initiated group representative versus group members shapes group members motives support intergroup helping study demonstrates collective self determination predicts support intergroup helping group pride well individual level self determined motivation study confirmed helping group members seen collectively self determined helping group representative producing effects pride well support study explores qualifier effects people identify strongly leader providing help also experience representative helping collectively self determined thereby promoting well group pride support findings highlight value integrating self determination theory intergroup theories consider collective aspects self determination
field software engineering modeling business processes complement tasks currently carried capture various requirements providing common easy graphical language understand allowing communication various actors one type important requirement must addressed data several studies show techniques methods obtain data model system business process models study presents overview research topic systematic mapping studies
new disturbance automated reference toolset dart developed monitor human land surface impacts using soil type ecological context dart identifies reference areas similar soils topography geology compares disturbance condition reference area condition using quantile based approach based satellite vegetation index dart able represent variation relative differences bare ground variation total foliar cover comparing sites nearby ecological reference areas using soil adjusted total vegetation index satvi assessment ecological recovery oil gas pads colorado plateau dart revealed half well pads percentile reference areas machine learning trend analysis poorly recovering well pads quantile bag error rates indicating moderate association environmental management variables hypothesized influence recovery well pads grasslands median quantile blackbrush coleogyne ramosissima shrublands arid canyon complexes warmer areas summer dominated precipitation state administered areas low recovery rates results showcase usefulness dart assessing discrete surface land disturbances highlight need targeted rehabilitation efforts oil gas well pads arid southwest published elsevier
control compliant mechanical systems increasingly researched several applications including flexible link robots ultra precision positioning systems control problem systems challenging especially gravity coupling large deformations inherent actuation combination lumped distributed parameters nonlinear system paper consider ultra flexible inverted pendulum cart propose new nonlinear energy shaping controller keep pendulum upward position cart stopped desired location design based model obtained via constrained lagrange formulation previously validated experimentally controller design consists partial feedback linearization step followed standard pid controller acting two passive outputs boundedness signals local asymptotic stability desired equilibrium theoretically established simulations experimental evidence assess performance proposed controller elsevier ltd rights reserved
study examines whether firm business strategy influences auditor reporting rely organizational literature develop prediction firms utilizing innovative prospector strategy likely firms utilizing cost leadership defender strategy receive going concern material weakness opinions empirical evidence supports prediction specifically find among sample financially troubled firms prospectors significantly likely defenders receive going concern opinion analyze sample clients subsequently filed bankruptcy find auditors less likely issue going concern opinions prospector clients indicates auditors commit type errors auditing prospector clients also find prospectors significantly likely defenders receive material weakness opinion taken together evidence suggests business strategy significant determinant going concern material weakness auditor reporting
introduction purposes present study examine effect intermittent exercise training musculoskeletal metabolic health postmenopausal premenopausal prm women furthermore evaluate whether adaptations maintained reduced training frequency methods eighteen mean sem prm women participated floorball training approximately two times per week subgroup women exercise training performed additional reduced training frequency approximately one training session per week results body fat percentage decreased total lean leg mass increased training period changes prm prm lean body mass maximal oxygen uptake doto max higher intermittent endurance test yyiet performance better training period procollagen type amino terminal propeptide higher total leg bone mineral density bmd higher prm training period total lean leg mass doto max yyiet performance level procollagen type amino terminal propeptide total leg bmd maintained whereas whole body bmd glycated hemoglobin hbac reduced expression muscle glucose transporter type higher conclusion twelve weeks intermittent exercise training increased bmd intermittent exercise capacity doto max prm also positive changes body composition additional training reduced frequency sufficient preserve physiological adaptations also improve blood glucose regulation
previous studies examined neural correlates emotion regulation neural changes evoked bymusic exposure however link music emotion regulation poorly understood objectives review synthesize known neural correlates emotion regulation music evoked emotions consider possibility therapeutic effects music emotion dysregulation music evoked emotions modulate activities cortical subcortical systems across cortical subcortical networks functions within networks integral generation regulation emotions since dysfunction networks observed numerous psychiatric disorders better understanding neural correlates music exposure may lead systematic effective use music therapy emotion dysregulation
background aim study evaluate occurrence intensity menopausal symptoms taking account length one relationship nature one assessment participants procedure study included women ages secondary higher education married cohabiting relationships women divided three groups depending experience related menopause premenopause respondents perimenopause respondents postmenopause respondents study used survey self design women health questionnaire whq hunter partner relations questionnaire pfb hahlweg results menopausal symptoms including greatest severity experienced women perimenopausal postmenopausal phases one relationship assessment lowest postmenopausal women group women relevant significant relations dimensions quality relationship menopausal symptoms numerous essential assessment one relating intimacy poor evaluation accompanied higher intensity experienced depression symptoms somatic symptoms disorders memory concentration sex sleep also sum menopausal symptoms higher three groups significant differences severity menopausal symptoms observed women marital cohabiting relationships women perimenopausal phase shorter length relationship seniority greater severity sexual dysfunction symptoms whereas women postmenopausal stage along length relationship severity psychological somatic symptoms increases conclusions one find perimenopausal postmenopausal phases particularly difficult women meaning intensity menopausal symptoms greatest assessment one relationship quality relevant menopausal symptoms experienced women perceive relationship intimate report less severe menopausal symptoms type relationship differentiate women regards experience associated menopause shorter longer seniority relationship may constitute risk factor triggering increase severity menopausal symptoms
timely accurate estimation winter wheat yield regional scale crucial national food policy security assessments near infrared reflectance sensitive leaf area index lai biomass winter wheat medium high canopy cover vegetation indices displayed saturation phenomenon however lai biomass medium high efficiently estimated using imaging data radar stronger penetration radarsat study following three objectives combine vegetation indices based previous studies estimating biomass winter wheat using radarsat imaging data combine radarsat imaging data aquacrop model using particle swarm optimization pso algorithm estimate winter wheat yield iii compare results assimilation radarsat imaging data imaging data radarsat imaging data aquacrop model using pso algorithm remote sensing data concurrent lai biomass yield sample fields acquired yangling district shaanxi china winter wheat growing season pso optimization algorithm used integrate aquacrop model remote sensing data yield estimation modified triangular vegetation index mtvi radar vegetation index rvi enhanced vegetation index evi rvi good relationships biomass respectively results indicated predicted measured yield rmse ton agreement estimated radarsat data used dynamic input variable aquacrop model estimated biomass radarsat data used dynamic input variable aquacrop model predicted yield showed agreement measured yield rmse ton results show using biomass dynamic input variable provides better yield estimation using dynamic variable predicted biomass yield accurately estimated combining radarsat data aquacrop model combining radarsat data aquacrop model using pso algorithm results indicated pso based assimilation method could used estimate winter wheat yield spot regional scale international society photogrammetry remote sensing inc isprs published elsevier rights reserved
aiming problems low precision using traditional response surface method structural reliability analysis high nonlinear implicit performance function gaussian process regression gpr model reconstructing response surface hybridized checking design point method solving reliability iterative algorithm presented reduce errors gpr response surface self adaptively thus new method namely gaussian process based response surface reliability analysis suspension bridge proposed research results show proposed method feasible proposed method advantages high efficiency excellent adaptability reliability analysis complex structural suspension bridge
suicide leading cause death america reported suicides per year mental illness major risk factor suicidality study attempts validate findings volumetric differences studies suicidality psychiatric inpatients classified mildly severe severe depression separated two groups suicide attempted past two months non suicidal control group patients depressed significantly different age gender race marital status education level anxiety level substance abuse healthy controls significantly different suicidal groups age gender volunteers underwent mri assess volumes cortical lobes corpus callosum subcortical regions interest including thalamus insula limbic structures basal ganglia right hippocampal volume group significantly reduced compared healthy controls frontal temporal lobe volumes group significantly decreased compared group volumetric reductions confirm previous findings support hypothesis fronto temporal function may altered suicidal patients published elsevier ireland ltd
earth pressure balance epb shields originally used fine grained soils well mixedgrained soils content fines least soils adequate consistency given epb shield used without additional ground conditioning application ranges epb shields successfully extended mixed grained coarse grained soils ground conditioning see herrenlcnecht soils foams required also foams polymers polymer suspensions high density slurries applied change properties soil excavation chamber far application ranges epb shields mixed grained coarse grained soils based experience former tunnelling projects different hydro geological boundaries different conditioning agents first investigations properties soil foam mixtures done different laboratories mair borio bezuijen investigations focus determination special properties conditioning agents conditioned soils laboratory investigations basis examination laboratory research carried institute tunnelling construction management ruhr university bochum germany using selected methods reproducible determination essential properties foams foams polymer additives polymer suspensions high density slurries results summarised doctoral thesis budach methods tested systematically regarding workability furthermore coarse grained soils mixed selected conditioning agents methods determine essential properties conditioned soils developed tested suitability well based results research application ranges epb shields developed based extensive laboratory research considering varying hydro geological ground conditions conditioning agents elsevier ltd rights reserved
shear mode piezoelectric materials widely used shunt damping vibrations utilizing surface interface shear stresses thick shear mode tsm elastic constant mechanical loss factor change correspondingly piezoelectric materials shunted different electrical circuits phenomenon makes possible control performance shear mode piezoelectric damping system designing shunt circuit however due difficulties directly measuring tsm elastic constant mechanical loss factor piezoelectric materials relationships parameters shunt circuits rarely investigated paper coupling tsm electro mechanical resonant system proposed indirectly measure variations tsm elastic constant mechanical loss factor piezoelectric materials main idea transform variations tsm elastic constant mechanical loss factor changes easily observed resonant frequency electrical quality factor coupling electro mechanical resonator based model formular relationships set theoretically mason equivalent circuit method validated finite element analyses finally prototype coupling electro mechanical resonator fabricated two shear mode pzta plates investigate tsm elastic constants mechanical loss factors different circuit shunted cases piezoelectric plate resonant frequency shifts bandwidth changes observed experiments good consistence theoretical analyses shunt conditions proposed coupling resonator obtained relationships validated limited pzta
hiv related stigma remains persistent global health concern among people living hiv aids plwa developing nations literature lacking studies healthcare students perceptions plwa study first effort understand stigmatizing attitudes toward hiv positive patients healthcare students mwanza tanzania directly treating patients also indirectly involved nonclinical roles handling patient specimens private health information total students drawn clinical medicine laboratory sciences health records information management community health classes tandabui institute health sciences technology voluntary survey assessed stigmatizing beliefs toward plwa students generally obtained high scores overall survey instrument pointing low stigmatizing beliefs toward plwa overall willingness treat plwa standard care patients however gaps knowledge exist among students comprehensive understanding routes hiv infection study also suggests students interact patients part training less likely exhibit stigmatizing beliefs toward plwa comprehensive course hiv infection one includes classroom sessions focused epidemiology routes transmission well clinical opportunities directly interact plwa perhaps teaching sessions led plwa may allow significant reductions stigma toward patients improve clinical outcomes plwa around world
paper presents fuzzy proportional integral controller fpic combined type predictor smith predictor proposed controller used controlling speed motor communication network solves problems constant random time delays data dropouts arising networks networked control systems ncss smith predictors inserted loop around controller plays role produce future predicted outputs proposed controller higher capability suppressing problems ncs simulation results established based matlab simulink truetime toolbox simulation results show performance fpic smith predictor greatly improved wide range networked time delay data dropouts
research investigated two competing explanations similarity effect byrne reinforcement model information processing perspective meta analysis laboratory based similarity studies explored moderators important similarity effect including set size proportion similarity centrality attitudes information salience results indicated effects proportion similarity centrality attitudes information salience largely consistent predictions information processing perspective discuss implications findings two perspectives models similarity effect role affect cognition experience interpersonal attraction
areas social life privileging whiteness rendered invisible donor insemination choices white lesbians making individual choices race potential children racialized politicized using qualitative data focus white women choose white donors rely racial markers avoiding overt discussions race explain racial preferences childrearing individuals interviewed rarely questioned decision use white donors even verbally acknowledged decision instance participants explicitly stated wanted white child display preferences terms skin colour hair colour eye colour ethnicity individuals assumed whiteness assumed decision explained research deconstructs narrative challenges invisibility
paper general system structure form block diagram well signal flow graph sfg multivariable nonlinear systems developed corresponding matrix formulation also done review several literature confirms structure developed paper may general suitable analysis self oscillations signal stabilisation multivariable nonlinear systems ease application structure prediction self oscillation illustrated example two dimensional nonlinear system
background detailed pain mapping extent distribution individuals patellofemoral pain pfp within around complex structure knee yet explored methods perceptions going pain adolescents young adults long standing months pfp collected high resolution digital body schema knees location area pain pain intensity laterality worse side knee pain symptom duration symmetry bilateral knee pain recorded threshold naturally occurring variations symmetrical knee pain drawings collected healthy controls used combination development symmetry index create fuzzy rule classifying symmetrical non symmetrical pfp patterns compared pfp expert symmetry index computed tested using correlation coefficient alone combination jaccard index true false positive rates tpr fpr respectively determined results peripatellar region common report pain location however novel nonconforming pfp patterns identified majority individuals bilateral pfp expressed highly symmetric mirror image pain individuals symptom duration years greater area pain compared symptoms less years total area pain correlated symptom duration extended symptoms durations progression towards shaped pattern emerged tpr identifying symmetrical knee pain patterns found however expert pfp tended stricter reflected fpr conclusions high proportion pfp patterns symptoms occur mirrored locations exceptionally symmetrical long duration symptoms appear converge shape classifying symmetrical pain patterns subjective however simple fuzzy rules correlations used increase objectivity study highlights gap knowledge pfp symptom presentation reveals may natural progression symptoms provides valuable clinical insight pain management treatment
work presents development innovative plasmonic optical fiber immunosensor detection cytokeratin biomarker interest lung cancer diagnosis development sensing platform assessed non liquid environments demonstrating surface plasmon resonance spr excited case purpose detections first carried encapsulated gel matrix aim mimicking tissue samples gold coated immunosensors embedded specifically designed packaging providing enough stiffness penetrate soft matters resulting reflected spectra revealed first time presence stable spr signal recorded soft matters experiments conducted detect trapped porous polyacrylamide gel matrix highlighted specific selective biosensor response towards target protein finally packaged immunosensor validated preliminary test human lung biopsy confirmed vivo detection consequently work represents important milestone towards detection biomarkers tissues still clinical challenge minimally invasive vivo medical diagnosis
treatment recommendations patients polycythemia vera well established multicenter trials investigating novel therapeutic strategies developed conducted university hospitals specialized academic centers majority patients germany however treated outpatient ambulatory setting aim study evaluate real life situation cohort patients analyzing data survey conducted private practices primary care centers eligible private practices primary care centers treating patients mpn recruited participate paper pencil based survey conducted march march germany hematologists asked report patient charts descriptive analyses conducted assess outcomes examined reported prognostic risk scores symptom scores clinical response criteria total centers participated retrospective survey provided data patients patients older age older years age main risk factor according criteria published tefferi colleagues molecular status diagnosis evaluated patients low rates constitutional symptoms reported physician based survey concentration problems fatigue itching main related symptoms phlebotomy hydroxyurea main cytoreductive measures hematocrit control majority patients responsive tolerant hydroxyurea therapy interferon jak inhibitor therapy used patients respectively overall leukocytosis thrombocytosis hematocrit could effectively controlled therapy applied lack efficacy reported reduction constitutional symptoms splenomegaly patient population investigated older participants published large multicenter trials majority patients categorized high risk age main risk factor molecular status unavailable majority patients diagnosed prior physician based survey reported significantly lower rates constitutional symptoms patient based surveys literature consistent previously published reports hydroxyurea main agent used therapy outpatient setting resulting efficient control hematopoietic parameters constitutional symptoms splenomegaly however may reduced efficiently could improved use jak inhibitor treatment high risk patients future
propose quantum public key encryption qpke protocol unknown multi qubit state based qubit wise teleportation private key computational boolean function whereas public key pair random bit string quantum state private key corresponds exponential number public keys security analysis showed proposed protocol information theoretic security attacks private key encryption multi partite quantum secret state sharing protocol presented based proposed multi qubit oriented qpke protocol secret state sharing protocol information theoretically secure
paper presents digital signal processing miniature multi channel multi sensor detection system based chemically functionalized comb micro capacitors low noise integrated analog electronics presented system capable detecting traces different molecules air currently possible detect less ppt target molecules atmosphere room temperature bandwidth multi channel measurements extreme requirements regarding sensitivity necessary appropriate analog signal processing electronics well digital signal processing hardware algorithms software complete architecture dsp part multi channel sensor measurement system explained together simulation measured results
background diabetes mellitus hyperglycemia associated increased susceptibility bacterial infections poor treatment outcomes post hoc evaluation treatment complicated intra abdominal infections ciai complicated urinary tract infections cuti aimed evaluate baseline characteristics efficacy safety patients without diabetes treated ceftolozane tazobactam comparators ceftolozane tazobactam antibacterial potent activity gram negative pathogens approved treatment ciai metronidazole cuti including pyelonephritis methods patients phase aspect studies without diabetes compared evaluate baseline characteristics efficacy safety ceftolozane tazobactam active comparators results significantly patients without diabetes years age older patients diabetes also likely weigh baseline renal impairment apache scores patients diabetes comorbidities increased incidence complicating factors ciai cuti clinical ciai composite cure cuti rates across study treatments lower patients without diabetes ciai cuti generally similar ceftolozane tazobactam active comparator treatment groups however significantly higher composite cure rates reported ceftolozane tazobactam levofloxacin patients without diabetes cuti significantly higher rates adverse events observed patients diabetes likely due comorbidities treatment related adverse events similar groups conclusions post hoc analysis patients diabetes general older heavier greater number complicating comorbidities patients diabetes lower cure rates significantly higher frequency adverse events patients without diabetes likely higher rates medical complications subgroup ceftolozane tazobactam shown least effective comparators treating cuti ciai population
paper exploits discrete jump alcohol consumption minimum legal drinking age mlda usa uses regression discontinuity design investigate relationship drinking risky sexual behaviors among young adults using confidential data national longitudinal survey youth cohort document young adults tend drink days granted legal access alcohol age although discrete jump alcohol consumption mlda associated increase probability sex percentage points significant impact probability engaging risky sexual behaviors among young adults also document effect mlda probability using several different birth control methods significant sex past weeks results robust alternative specifications imply although mlda law quite effective reducing alcohol consumption among young adults spillover effects law risky sexual behaviors relatively limited
paper present architecture demonstrates multimodal fusion fission using semantic agents web services interacts worldwide web computers services users solution extracts meaning situation using semantic memory agents manage interaction process involved fusion values different sensors produces event needs implementation fission process suggests detailed set actions implementation actions implemented actuators actions first evaluated virtual environment mimics real world environment danger arises virtual evaluation implementation feasible otherwise might need add one smaller actions render action safe free danger work presents following contributions design agent memory model world environment using knowledge representation language compatible current standards creation pervasive architecture several scenarios composition adaptation iii presentation agents services interact provide support real world simulation event virtual environment assess feasibility event implementation authors published elsevier
deployment technology across globe towards efficient learning environments growing rapidly united kingdom example government investing million pounds towards primary secondary school early programming lessons similar investments happening countries ideology behind push strengthen link younger generation technological growth continue ever increasing impact upon lives fuel pace innovation one core themes area computer programming overlooked level education recently paper convey research development tutoring systems supporting learning computer programming early years schooling also discuss depth significant statistical results experimental study conducted one primary schools fifty two pupils participated experimental study divided three groups comprising different ages skill sets
work device made order help visualization student pid temperature control thus fix concepts learned classroom device built primarily picf microcontroller mini cooler heat resistor temperature sensors liquid crystal display usb connector transistors leds potentiometers resistors capacitors usb connection responsible recording microcontroller firmware bootloader mode interfacing supervisory software supply system heat resistor provides heat system hand cooler function removing heat system liquid crystal display helps student check temperature constants controller set point temperature cooler voltage potentiometers provide option run system open loop serve make control heat supplied heat resistor cooler voltage manually heat resistor cooler controlled via transistors switched pwms pulse wide modulation computer program developed sharp language display temperature time measured sensors program also used adjust constants controller temperature set point microcontroller firmware allows system operate open closed loop modes work allows student learn practice control actions controller parameters changed contributing improve acknowledgment control engineering
components renin angiotensin system ras expressed kidney bone kidney disease bone injury common complications associated diabetes study aimed investigate effects angiotensin converting enzyme inhibitor captopril kidney bone mice mice orally administered gavage captopril weeks mice non diabetic control serum urine biochemistries determined standard colorimetric methods elisa histological measurements performed kidney periodic acid schiff staining tibial proximal metaphysis safranin masson trichrome staining trabecular bone mass bone quality analyzed microcomputed tomography quantitative polymerase chain reaction immunoblotting applied molecular analysis mrna protein expression captopril significantly improved albuminuria glomerulosderosis mice effects might attributed regulation angiotensin expression expression stream profibrotic factors kidney like connective tissue growth factor vascular endothelial growth factor urinary excretion calcium phosphorus markedly increased mice response captopril treatment captopril induced decrease bone mineral density deterioration trabecular bone proximal metaphysis tibia mice shown histological reconstructed dimensional images even though captopril effectively reversed diabetes induced changes calcium binding protein vitamin receptor expression kidney well expression ras components bradykinin receptor bone tissue treatment captopril increased osteoclast covered bone surface reduced osteoblast covered bone surface regulated expression type collagen transcription factor runt related transcription factor markers osteoblastic functions regulated expression carbonic anhydrase marker bone resorption captopril exerted therapeutic effects renal injuries associated type diabetes worsened deteriorations trabecular bone mice latter least part due stimulation osteoclastogenesis suppression osteogenesis captopril elsevier inc rights reserved
non point source water pollution mainly comes farmland chemical fertilizers become obstacle agricultural sustainability ecological health public policy tool assessing global ecological crisis environmental pollution ecological compensation important regional agricultural sustainability ecological compensation farmers receive governments based reduction fertilizer application optimal ecological economic levels study estimated ecological compensation standards nitrogen non point pollution yixng city contingent valuation method cost benefit method results showed range theoretical values ecological compensation nitrogen yixing city depended upon optimal ecological economic nitrogen application levels willingness farmers accept compensation positively correlated farming experience education half farmers willing accept compensation based present study found yixing ecological compensation standard controlling nitrogen non point pollution yuan current economic development level
family dinner family therapy confer many similar benefits family members settings families connect interact group designated space time last years large body research documents physical academic mental health benefits family dinners research links regular family meals healthier eating habits lower obesity rates lower rates substance abuse teen pregnancy depression stress anxiety well stronger self esteem parent child connectedness resilience even better vocabularies family therapists harness benefits four ways first asking screening questions families determine whether often sharing meals discussing solutions overcoming common obstacles second asking enacting family dinner obtain snapshot family organisation functioning terms gender roles division labour expression affect conflict capacity fun tolerance difference third playing non competitive games therapy promote conversation games also played dinner table fourth using family dinner annex therapy place experiment new roles behaviours patterns communication enacted nightly basis discussed therapy two case examples presented illustrate ways dinner place change begun therapy implemented home
clinical immunology literature punctuated research psychosocial dimensions illness studies investigating lived experiences stated needs patients primary immune deficiencies families essential improving clinical management determining research questions matter patients stakeholders yet move field forward systematic review literature proposed agenda needed systematic review conducted via pubmed scopus include original research psychological social behavioral aspects primary immune deficiencies published title abstract keyword search conducted candidate article abstracts manually reviewed forward backward reference searches completed twenty nine studies met inclusion criteria illuminate complex psychological social emotional experiences primary immune deficiency themes included potential negative psychosocial impact disease adaptation time multi dimensional assessments quality life familial impact important roles hope developing sense control social support addressing anxiety depression patients families methodological considerations areas improvement discussed propose research agenda focus study creativity rigor improved engagement existing literature critical study design methodology adequate statistical power careful variable selection etc review highlights opportunities advance psychosocial research bring brighter future clinicians researchers families affected primary immune deficiency
design analog filter using active building block gained significant attention become interesting research topic five inputs single output voltage mode universal biquadratic filter using active building block namely voltage differencing differential difference amplifier vddda presented paper proposed filter consists two vdddas two grounded capacitors presented circuit high impedance input voltage nodes low impedance output voltage node ideal cascade voltage mode circuit without use buffer circuits provide five output voltage functions band pass low pass band reject high pass pass responses high pass band pass functions inverting non inverting response achieved matching condition inverting double gain amplifier required easy select output response digital method natural frequency quality factor electronically tuned attractive microcomputer microcontroller controllability verify validity proposed filter pspice simulation experimental results using vddda constructed commercially available included measured results agree well theoretical expect elsevier gmbh rights reserved
backgroundprenatal alcohol exposure pae result array morphological behavioral neurobiological deficits range severity despite extensive research field significant progress made especially understanding range possible malformations neurobehavioral abnormalities molecular mechanisms alcohol responses development still well understood multiple transcriptomic studies looking changes gene expression pae animal models however limited apparent consensus among reported findings effort address issue performed comprehensive analysis meta analysis suitable publically available expression data sets methodswe assembled microarray data sets gene expression pae mouse rat models consisting samples total ethanol etoh exposed control animals analyzed data set differential expression used results perform meta analyses considering data sets together grouping time duration exposure pre postnatal acute chronic respectively performed network gene ontology enrichment analysis characterize identified signatures resultsfor subanalysis identified signatures differential expressed genes show support multiple studies overall changes gene expression extensive acute etoh treatment prenatal development models considering analysis data together identified robust core signature genes regulated pae regulated genes functional analysis reveals representation genes involved protein synthesis mrna splicing chromatin organization conclusionsour meta analysis shows existing studies despite superficial dissimilarity findings share features allow identify common core signature set transcriptome changes pae important step identifying biological processes underlie etiology fetal alcohol spectrum disorders
parent origin dependent epi genetic factors important determinants prenatal development program adult phenotype however data magnitude specificity maternal paternal genome effects fetal bone lacking used outbred bovine model dissect quantify effects parental genomes fetal sex nongenetic maternal effects fetal skeleton analyzed phenotypic molecular relationships fetal muscle bone analysis bone morphometric weight parameters fetuses recovered day gestation term identified six principal components explained variation skeletal parameters parental genomes accounted variation bone wet weight limb ossification flat bone size axial skeletal growth limb length showed lesser effects parental genomes significant nongenetic maternal effect gestational weight gain fetal sex affected bone wet weight limb length partitioning variation explained parental genomes revealed strong maternal genome effects bone wet weight axial skeletal growth whereas paternal genome controlled limb ossification histomorphometric data revealed strong maternal genome effects growth plate height trabecular thickness distal femur parental genome effects fetal bone mirrored maternal genome effects fetal serum hydroxyvitamin paternal genome effects alkaline phosphatase correlations maternally controlled bone wet weight paternally controlled limb ossification respectively bone wet weight flat bone size correlated positively muscle weight negatively muscle expression imprinted maternally expressed regulates growth factors mirna interference suggests muscle bone interaction via epigenetic factors american society bone mineral research
late government federal territory quintana roo introduced cooperative system chicle industry controlled chewing gum companies contratistas intermediaries companies chicle producers however project ended failure various factors including impact great depression companies boycott competition chicle raw materials chewing gum corruption inefficiencies government discord local federal governments
concomitant effects hydraulics reaction kinetics disinfection efficiency chlorine contact tank cct setups experimentally assessed test predictive ability first order kinetics models chick watson rule wehner wilhelm prototype tests conducted using river water characterised quality parameters chlorine demand inactivation rates total thermotolerant coliform poor average superior cct baffling conditions assessed tracer experimentation three chlorine dosages models predictive ability comparable high superior baffling decreased differently hydraulic efficiency maximum errors positive bias shown renders unsafe cct design results favoured rule preferred analytical tool comparable complexity potential refinements models could lead operational savings identified
study examined moderating role gender coping strategies relationship perceived family support self esteem depressive symptoms data used world survey second level mws national survey mental health among young people aged years conditional process analyses indicated planned coping moderated relationship perceived family support depressive symptoms engaging low moderate levels high levels planned coping moderating role stronger females males avoidance coping moderator engaging moderate high low levels avoidance coping gender also moderated relationship support focused coping moderated perceived family support depressive symptoms relationship females findings suggest strength relationship perceived family support depressive symptoms depends level engagement particular coping strategy engagement consistently stronger moderator females
self healing capacities geosynthetic clay liners gcls investigated using laboratory leakage rate tests two types gcl tested first type geomembrane supported gcl gcl second type geotextile encased gcl gcl diameters defects investigated ranged overburden stress sigma varied range kpa tap water solution nacl tap water solution ethanol tap water used liquid permeants test results indicate gcl gcl defects diameters less self healed providing liquid tap water ethanol tap water solution factors tend reduce thickness diffusive double layer around particles bentonite tend reduce self healing capacity gcl free swelling index bentonite used gcl used evaluate self healing capacity applied stress two possible effects self healing capacity one squeezing hydrated bentonite damage hole another limiting amount hydration induced expansion bentonite conditions tested self healing capacity increased increasing applied stress elsevier ltd rights reserved
clinical practice guide examine diagnostic therapeutic management adult patients constipation abdominal discomfort confluence spectrum irritable bowel syndrome functional constipation fall within framework functional intestinal disorders major personal health social impact altering quality life patients affected former subtype irritable bowel syndrome constipation altered bowel habit predominate often along recurring abdominal pain bloating abdominal distension constipation characterised infrequent hard pass bowel movements often accompanied straining defecation sensation incomplete evacuation underlying organic cause majority cases considered functional bowel disorder many clinical pathophysiological similarities two conditions constipation responds similar way commonly used drugs fundamental difference presence absence pain nothing way severity disorders depends intensity intestinal symptoms also biopsychosocial factors association gastrointestinal extraintestinal symptoms degree involvement forms perception behaviour functional bowel disorders diagnosed using rome criteria clinical practice guide adapts rome criteria published end may first part examined conceptual pathophysiological aspects alarm criteria diagnostic test referral criteria primary care gastroenterology second part reviews available treatment alternatives exercise fluid ingestion diet soluble fibre rich foods fibre supplements dietary components osmotic stimulating laxatives probiotics antibiotics spasmolytics peppermint essence prucalopride linaclotide lubiprostone biofeedback ant depressants psychological treatment acupuncture enemas sacral root neurostimulation surgery practical recommendations made elsevier espana
purposethe occurrence pressure ulcers prus challenges care facilities studies report pru reduction efforts long term acute care ltac study described pru reduction efforts single ltac facility using medline pressure ulcer prevention program mpupp designthis study quasi experimental quality improvement project pre postmeasurement design methodsoutcomes tracked months mpupp implemented month education caregivers provided interactive web based suite addition patient care technicians attended week hour inservice new skin care products implemented facility also implemented algorithm treatment wounds findingsthere significant reduction mean monthly hospital acquired pru npru rate preprogram compared postprogram conclusionssustainable npru reduction achieved mpupp clinical relevanceltac hospitals could expect reduce npru education incentive caregivers
objective evaluate potential predictors non response treatment onabotulinum toxin onabonta women refractory detrusor overactivity subjects methods secondary analysis randomized trial onabonta versus placebo women refractory analyzed baseline week follow data univariate multivariate logistic regression used assess demographic factors baseline clinical parameters non response treatment defined less improvement urinary urgency leakage episodes less voiding frequency achieving continence change worse pgi score weeks results one hundred twenty two women included twenty nine non responders treatment urgency voiding leakage episodes respectively fifty nine failed achieve continence non responders pgi scale smoking status predicted non response urgency episodes higher baseline leakage episodes predicted non response achieving continence increasing age body mass index bmi showed marginal associations non response pgi scale conclusion onabonta effective treatment refractory fail respond identification women risk data indicate smokers advised lesser chance successful treatment older women high bmi severe leakage also higher risk failure wiley periodicals inc
background attrition pediatric weight management negatively impacts treatment outcomes potentially modifiable contributor attrition unmet family expectations study aimed evaluate association adolescent parent guardian treatment expectations attrition patients methods prospective nonrandomized uncontrolled single arm pilot trial conducted among pediatric weight management programs children hospital association focus fitter future collaborative parents guardians adolescents completed expectations goals survey initial visit categories including healthier food drinks physical activity exercise family support behavior weight management goals attrition assessed months results january august parents guardians recruited reported children adolescents children years adolescents also self reported attrition rate months adolescents greater interest family support behavior skills associated decreased odds attrition months odds ratio confidence interval discordant parent adolescent dyad responses category higher odds attrition months weight loss important weight management goal adolescents parents adolescents goal median weight loss goal pounds attrition associated adolescent weight loss goals desired median median median conclusions assessing initial expectations may help tailor treatment meet families needs especially focus family based change realistic goal setting
jitter limitations pose significant challenges high resolution sampling rate analog digital converters adcs paper describes integrate sample ias receiver suitable use optical parametric photonic adc rate scalable photonic sampling techniques provide low jitter optical sampling analog digital conversion wideband signal ghz beyond bit ias receive channel described rate scalable photonic adc electronic measurements shown tone photonic gaussian pulse source compared simulations two channel ias array fabricated sige bicmos process packaged onto printed circuit board integration photonic sampling setup single channel achieves measured performance higher enob two channel integrated circuit consumes per channel supplies occupies area
paper aims present methodology control position clutch actuator objective improve position reference tracking order get better performances accuracy clutch slip control originality work use model takes account nonlinear characteristic stiffness clutch diaphragm instead robustness approach nonlinearity managed using quasi lpv takagi sugeno representation additionally nonlinearity switching developed control law consequently nonlinear switching one moreover order use unmeasured values controller current electric motor takagi sugeno switching observer designed simulation results highlight efficiency proposed approach ifac international federation automatic control hosting elsevier ltd rights reserved
highly sulfated glycosaminoglycan gag heparin widely used clinic anticoagulant researchers using enhance stem cell expansion differentiation protocols well improve delivery growth factors tissue engineering strategies growth differentiation factor gdf belongs bone morphogenetic protein family proteins vital skeletal formation however interaction heparin heparan sulfate studied identify gdf novel heparin binding protein show proteoglycans vital localizing gdf cell surface clinically relevant doses heparin equivalent concentrations found inhibit gdf biological activity human mesenchymal stem stromal cell derived chondrocyte pellet cultures skeletal cell line atdc also found heparin inhibited gdf binding cell surface gdf induced induction smad signaling furthermore gdf significantly increased aggrecan gene expression chondrocyte pellet cultures without affecting collagen type expression making promising target articular cartilage importantly study may explain variable disappointing results seen heparin loaded biomaterials skeletal adverse skeletal effects reported clinic following long term heparin treatment results caution use heparin clinic applications prompt transition using specific gags derivatives better defined structures fewer target effects
internet provides convenient environment data collection psychology modern web programming languages javascript flash actionscript facilitate complex experiments without necessity experimenter presence yet always question much noise added due differences setups used participants whether compensated increased ecological validity larger sample sizes especially problem experiments measure response times rts sensitive hence susceptible noise example choices per used simple visual search task different set sizes compare laboratory performance web performance results suggest although locations means distributions different distribution parameters furthermore effect experiment setting depend set size suggesting task difficulty important choice data collection method also collected additional online sample investigate effects hardware software diversity accuracy data found high diversity browsers operating systems cpu performance may detrimental effect though partly compensated increased sample sizes trial numbers sum findings show web based experiments acceptable source data comparable common keyboard based setup laboratory
objectiveswhile health promotion patient education central scope practice professional nurses often feel ill equipped assume role sexual health educator lack adequate knowledge skills effectively engage parents adolescent sexual reproductive health efforts design sampleemploying mixed methods study consisting pre post test survey exit interviews pilot study conducted assess impact implementing parent based adolescent sexual health intervention baccalaureate nursing student outcomes resultswe found statistically significant improvements student outcome expectancies parenting strategies barriers sexual health communication self efficacy sexual health counseling experience using thematic content analysis exit interview content emerging themes need increased sexual reproductive health srh preparation wanting greater experience opportunity involvement nursing research educational gaps family focused community public health conclusionsincorporating adolescent sexual health education public health nursing clinical training prepare nurses parent based adolescent sexual health educators core competency nurses working families communities across health care delivery settings
objective present case distal tibiofibular sprain rare injury amongst ubiquitous lateral ligament sprains ankle clinical features year old recreational hockey player treated ankle sprain demonstrating increased translation drawer test pain inversion stress also pain external rotation dorsiflexion rays demonstrated fractures intervention outcome conventional protocol protect rest ice compress elevate price employed common lateral ankle sprains followed early mobilization proprioceptive training tilt board recovery prolonged ossification ankle syndesmosis seen follow radiographs conclusion management implications outcome sequelae uncommon syndesmotic sprain severe commonly seen lateral ankle sprain simple physical examination procedures useful identifying syndesmotic sprains routine examination injured ankle emphasized include dorsiflexion external rotation stress squeeze test
acoustoelastic effect japanese fast growing trees experimentally investigated order apply acoustoelastic technique nondestructive stress analysis timber structure velocities shear waves propagated melia azedarach changed depending applied stress type compression tension longitudinal stresses produced wood beam static bending measured using acoustoelastic constants obtained pure tension compression tests stress values obtained acoustoelastic method good agreement obtained strain gauge method strength materials formulae findings suggested potential applying acoustoelastic effect determine stress condition azedarach elsevier ltd rights reserved
designed delivery system obtain efficient optimal nose brain transport bace sirna potentially useful treatment alzheimer disease selected cell penetrating peptide short peptide derived rabies virus glycoprotein known rvg increase transcellular pathway neuronal cells optimal molar ratio rvg bace sirna elucidated complex two encapsulated propose chitosan coated uncoated solid lipid nanoparticles slns nasal delivery system capable exploiting olfactory trigeminal nerve pathways coating process effect zeta potential obtaining positively charged nanoparticles sirna protection positive charge coating formulation ensured mucoadhesiveness particles also prolonged residence time nasal cavity studied cellular transport sirna released slns using caco model epithelial like phenotypes found sirna permeates monolayer greater extent released studied formulations bare sirna primarily chitosan coated slns elsevier rights reserved
investigation paper inhomogeneous higher order nonlinear schrodinger equation describes transmission subpicosecond femtosecond optical solitons inhomogeneous optical fibers bilinear forms obtained help auxiliary function symbolic computation degenerate nondegenerate solitons derived solitons form single hump double hump flat top profiles displayed soliton amplitude affected third order dispersion coefficient self steepening coefficient soliton velocity related third order dispersion coefficient interactions two nondegenerate solitons asymptotically discussed including periodic cross interactions single hump soliton double hump soliton independent propagation overtaking interaction happen two double hump solitons solitons keep shapes invariant cross interactions except phase shifts
social bonds critical survival adaptation periods bond formation involve reorganization neurobiological systems mediated social behavior theoretical accounts animal studies suggest similarity parent infant pair bonding hypothesis yet directly tested humans study recruited three groups human adults parents firstborn child last months new lovers began romantic relationship within past months non attached singles measured plasma oxytocin beta endorphin beta end interlukin biomarkers affiliation reward stress response systems micro coded gaze affect synchrony parents infants among new lovers social interaction significantly increased periods parental romantic bonding highest new lovers contrast beta end highest new parents lowest singles biomarkers became tightly coupled periods bond formation inter correlation among hormones highest romantic bonding structural equation modeling indicated effects beta end behavioral synchrony mediated impact highlighting integrative role oxytocinergic system supporting human social affiliation findings suggest periods bond formation accompanied increased activity well tighter cross talk among systems underpinning affiliation reward stress management research multidimensional process bonding may shed light effects attachment health elsevier inc rights reserved
paper first introduce generalized alternated system definition julia set generalized alternated system given called generalized alternated julia set achieve control generalized alternated julia sets applying classic control methods gradient control optimal control addition synchronization two different generalized alternated julia sets implemented using gradient control optimal control simulations illustrate effectiveness correctness two control methods results displayed computer graphics
study investigates effects post weaning water restriction performance nutrient digestibility carcass traits meat quality day old rabbits total weaned rabbits days randomly divided two groups basis sex two groups fed diets libitum post weaning days fattening days periods post weaning period one group also received drinking water libitum whereas water restriction days day days day days day days day fattening period groups water free access individual live weights feed intake per cage recorded weekly cages randomly chosen per group rabbits calculate gain feed intake feed conversion ratio fcr apparent digestibility values nutrients measured using acid insoluble ash carcass data collected rabbits males females per group selected similar final groups mortality days higher group respectively gain higher group post weaning entire period water restriction reduced feed intake post weaning entire period fattening period fcr lower group respectively apparent digestibilities dry matter organic matter ndf adf cellulose greater restricted rabbits respectively perirenal scapular fat percentages higher rabbits respectively water restriction increased saturated fatty acids lauroleic acid polyunsaturated fatty acids ratio applied water restriction days executed winter months improved digestive health rabbits negative effects carcass traits physical chemical meat characteristics however animal welfare point view water restriction criticized method restrict feed intake
development level economy society improves technology changes quickly human society informatization degree also deepens continuously distinguishing feature information age gradual promotion internet computer meanwhile internet technology computer technology also prevent booming development trend present internet computer successfully entered field production life people work learning living modes change greatly although internet technology computer technology establish close relationship field social life people ignore potential safety hazard internet computer caused people production life basis paper aims briefly introduce computer network security analyze reasons computer network security discuss feasible measures improve computer network security propose suggestions improving level computer network security
recently cortisol suggested moderate positive relationship testosterone antisocial behavior precisely high testosterone levels found related aggressive dominant behavior especially cortisol levels low present study aimed extend findings pro environmental behavior indicator prosocial behavior first step male participants provided information everyday pro environmental behavior completing online questionnaire various energy saving behaviors second step subjects provided two saliva samples assessment testosterone cortisol two subsequent mornings awakening found testosterone negatively related pro environmental behavior men low cortisol conclusion findings provide first evidence joint association testosterone cortisol everyday pro environmental behavior results reinforce importance considering interdependent hormone systems simultaneously rather focusing single hormone
carried animal toxicity tests chemicals chemical safety program implemented ministry economy trade industry japan tested tert butoxy chlorobenzene combined repeat dose developmental reproductive toxicity test test chemical administered daily gavage week old crl rats doses males treated beginning mating females treated mating day lactation decreased spontaneous locomotion decreased respiratory rate incomplete eyelid opening observed sexes resolved within min administration suggesting central nervous system depression notable changes observed body weight food consumption functional battery tests blood test increased liver weight centrilobular diffuse hepatocyte hypertrophy observed sexes biochemical histopathological changes related hepatotoxicity increased kidney weight basophilic tubules tubule dilatation increased hyaline droplets observed males dosed immunohistochemical staining indicated alpha globulin nephropathy male rat specific toxicity although kidney weight also increased females dosed considered adverse effect histopathological changes pup weights postnatal day decreased still decreased postnatal day data indicated observed adverse effect level repeated dose reproductive developmental toxicity tert butoxy chlorobenzene
evaluated prevalence osteoporosis using osteoporosis diagnostic criteria developed national bone health alliance nbha includes qualified fractures frax score addition bone mineral density bmd expanded definition increases prevalence compared bmd alone definitions however may better identify elevated fracture risk purpose paper estimate prevalence osteoporosis adults years using nbha osteoporosis diagnostic criteria utilizing data national health nutrition examination survey nhanes identified participants osteoporosis one following femoral neck lumbar spine score low trauma hip fracture irrespective bmd clinical vertebral proximal humerus pelvis distal forearm fracture score frax score national osteoporosis foundation intervention thresholds hip fracture major osteoporotic fracture estimated prevalence overall gender age sample included men women approximately years racial ethnic minority groups estimated men women years osteoporosis prevalence increases age men women years combination frax score fractures largest contributing factor defining osteoporosis men whereas score largest contributing factor women found men women osteoporosis based nbha diagnostic criteria although expanded definition increases prevalence compared bmd alone based definitions may better identify elevated fracture risk order reduce burden fractures older adults
application development computer technology driven promoted change information technology computer information technology wide range penetration affinity influences world economy social development aspects twenty first century human life closely linked internet closely related electronic commerce information platform etc however kinds problems arise example many threats attacks existing internet making network security damaged cause disclosure information system platform network resources attack consequence terms ensure information sent received truly completely effectively legally issue network security become current research hot spot paper allusion problem introduces analyzes several typical computer network security technologies including firewall technology virus protection technology virtual private network technology also called vpn technology
background treatment chronic hypersensitivity pneumonitis chp often includes systemic oral corticosteroids optimal pharmacologic management remains unclear morbidity associated prednisone motivated search alternative therapies aimed determine effect treatment mycophenolate mofetil mmf azathioprine aza lung function patients chp methods patients chp treated either mmf aza retrospectively identified four interstitial lung disease centers change lung function treatment initiation analyzed using linear mixed effects modeling lmm adjusting age sex smoking history prednisone use results seventy patients included treated withmmfand aza median follow treatment initiation months prior treatment initiation fvc diffusion capacity lung carbon monoxide dlco predicted declining amean rate per month respectively treatment either mmf aza associated improved fvc year associated statistically significant improvement dlco year treatment results similar subgroup patients treated mmf year fvc increased nonsignificantly dlco increased conclusions treatment mmf aza associated improvements dlco patients chp prospective randomized trials needed validate effectiveness chp
one stage bilateral muscle preserving calcar guided implantation technique modified minimally invasive anterolateral approach supine position bilateral primary secondary osteoarthritis hip bilateral femoral head necrosis asa iii asa severe osteoporosis factors jeopardizing stable anchorage cementless calcar guided short stem infection supine position skin incision opening fascia blunt dissection pushing gluteal muscles dorsally index finger capsulectomy individual osteotomy according preoperative plan determine short stem position remove femoral head prepare acetabulum position cup femoral preparation curved opening awl spare greater trochanter gluteal muscles insert trial rasps ascending sizes round corner technique select offset version trial reposition intraoperative radiograph implantation definitive implant wound closure consultation anesthesiologist confirm stable patient procedure contralateral hip mobilization day immediate full weight bearing remove wound drains urinary catheter female patients day intensive protocol physiotherapy rehabilitation thrombosis prophylaxis rehabilitation day almost patients undergone surgery since first consecutive patients hips prospectively evaluated years harris hip score satisfaction visual analogue scale low peri postoperative complication rates implant revisions muscle sparing approach special round corner technique one stage bilateral procedure leads rapid mobilization rehabilitation excellent early clinical results high satisfaction rates
semiarid areas slope restoration usually hampered high rainfall temperature variability may cause severe erosion slope instability also environmental stresses long term drought temperature extremes lead revegetation failure study three types geotextiles including jute mat polyester mat polyester net installed slopes effects erosion control vegetation growth investigated laboratory field experiments results rainfall simulation experiments laboratory plots showed could delay time runoff reducing runoff decrease erosion respectively field studies also conducted restored rock slope fengshan quarry northeast beijing china results indicated could increase soil moisture respectively provide moderate soil temperatures facilitate vegetation growth geotextiles less effective result degradation time slope stability plant growth however affected due developed vegetation cover thus geotextiles could protect slopes preventing erosion creating favourable soil conditions revegetation especially initial stage slope restoration natural geotextile mat jute mat preferred since effective environmental friendly elsevier rights reserved
rising number newly insured young adults brought health care reform soon increase demands primary care physicians physicians face young adult patients presents opportunity prevention oriented care present study evaluated whether brief observer reports young adults personality traits could predict individuals would greater risk poor health entered midlife following cohort individuals dunedin multidisciplinary health development study moffitt caspi rutter silva show brief measures young adults personalities predicted midlife physical health across multiple domains metabolic abnormalities cardiorespiratory fitness pulmonary function periodontal disease systemic inflammation individuals scoring low traits conscientiousness openness experience went develop poorer health even accounting preexisting differences education socioeconomic status smoking obesity self reported health medical conditions family medical history moreover personality ratings peer informants knew participants well nurse receptionist met participants first time predicted health decline young adulthood midlife despite striking differences level acquaintance personality effect sizes par well established health risk factors socioeconomic status smoking self reported health discuss potential utility personality measurement function inexpensive accessible tool health care professionals personalize preventive medicine adding personality information existing health care electronic infrastructures could also advance personality theory generating opportunities examine personality processes influence doctor patient communication health service use patient outcomes
paper introduces new method solve cross domain recognition problem different traditional domain adaption methods rely global domain shift classes source target domains proposed method flexible capture individual class variations across domains adopting natural widely used assumption data samples class lay intrinsic low dimensional subspace even come different domains proposed method circumvents limitation global domain shift solves cross domain recognition finding joint subspaces source target domains specifically given labeled samples source domain construct subspace classes construct subspaces target domain called anchor subspaces collecting unlabeled samples close highly likely belong class corresponding class label assigned minimizing cost function reflects overlap topological structure consistency subspaces across source target domains within anchor subspaces respectively combine anchor subspaces corresponding source subspaces construct joint subspaces subsequently one versus rest support vector machine classifiers trained using data samples belonging joint subspaces applied unlabeled data target domain evaluate proposed method two widely used datasets object recognition dataset computer vision tasks sentiment classification dataset natural language processing tasks comparison results demonstrate proposed method outperforms comparison methods datasets
paper discusses counterfactual scripting critically inquire give form participatory design processes age ubiquitous participation often superficial application various societal domains processes instruments participation often cut loose political context stories happened process told clear storyline develops logically via different design moves towards well defined plot leaving alternative narratives inspired counterfactual history reject teleological perspective explore counterfactual scripting way give renewed attention political context giving form design process pluralistic process focuses future creates alternatives past speculate future evaluate counterfactual thinking participatory architecture urban planning process
drastic changes occur formation intestinal loop including elongation physiological umbilical herniation puh midgut rotation fifty four sets magnetic resonance images embryos carnegie stage used reconstruct embryonic digestive tract three dimensions amira program elongation puh rotation quantified relation proximal part superior mesenteric artery sma designated origin rotation initially observed slight deviation duodenum colorectum median plane puh noticeable showed hairpin like structure sma running parallel straight part cecum located left began form complex structure result rapid growth small intestinal portion starting point moved right cranial region area caudal origin though elongation duodenum conspicuous change almost position end remained roughly place left caudal origin notably rotated around origin earlier stages gradually moved away running transversely movements may explained result differential growth suggesting rotation passive wiley periodicals inc
several epidemiological studies suggested possible link exposure diisononyl phthalate dinp development allergies findings remain controversial since insufficient scientific evidence assess ability dinp influence allergic immune responses addition mechanisms behind dinp caused allergic diseases fully elucidated study balb mice orally exposed dinp weeks sensitized fluorescein isothiocyanate fitc showed oral exposure dinp could aggravate allergic dermatitis like lesions indicated increase number mast cells increased skin edema fitc induced contact hypersensitivity deterioration concomitant increased total serum immunoglobulin cytokines determined oxidative damage activation nuclear factor data demonstrated dinp could promote oxidative damage activation skin expression thymic stromal lymphopoietin activation signal transducer activator transcriptions enhanced concomitant exacerbated allergic dermatitis effects activation induced dinp effects alleviated pyrollidine dithiocarbamate inhibitor results suggest oral exposure dinp aggravated allergic contact dermatitis positively regulated via
mounting evidence indicates pain motivate cigarette smoking behavior smokers reliably endorsed use tobacco cope pain reason suspect pain may impede smoking cessation smoking related outcome expectancies among best predictors cigarette consumption relapse goal pilot study develop standardized measure tobacco smokers perceive pain smoking behavior interrelated pain motivator smoking expectancies smoking means coping pain pain barrier quitting participants completed online survey designed assess interrelations pain tobacco smoking nine item pain smoking inventory psi demonstrated excellent internal consistency expected psi scores higher among smokers chronic pain pain positively associated established indices pain tobacco smoking dependence results corroborate notion smokers effectively communicate perceptions interrelations pain smoking behavior future research needed establish reliability validity psi among larger diverse samples smokers varying levels pain future work also examine psi scores predictors smoking cessation outcomes whether psi data may usefully inform development tailored interventions smokers pain
mobile hoc network take static infrastructure depend neighbors convey message mobile nodules travel network unrestricted fashion unlike wired networks fixed committed link exists nodes self organizing capability nodes manet made trendy among crucial mission functions like military usage emergency rescue hence manet security essential importance unfortunately open medium eclectic supply nodes dynamic topology make manet defenseless malevolent attackers circumstance crucial foster proficient intrusion detection mechanisms guard manet number attacks lot techniques suggested intrusion detection specifically manets article put forward review date intrusion detection procedures manets comparisons
report case years old woman presented clinical picture consisting skin rash pruritus astenia mialgia progressive onset last month recently discovered blood hypereosinophilia patient exhaustively investigated secondary causes hypereosinophilia excluded mainly allergies parasitic infections autoimmune neoplastic diseases hospital admission patient symptoms personal history suggesting cardiac disease initial electrocardiography echocardiography minimal changes cardiac markers probnp troponin high values clinical evolution initially good moderate dose corticosteroid therapy eosinophilia leukocytosis cardiac markers continued increase followed progressive cardiac ischemia ultrasound changes considered rare case primary hypereosinophilic syndrome severe cardiac involvement switched high dose corticosteroid followed add therapy hydroxyurea blood eosinophilia decreased cardiac markers ischemia continued aggravate unfortunately patient died due sudden cardiac arrest three weeks hospital admission concluded hypereosinophilic syndrome early progressive cardiac involvement severe difficult manage disease high fatality risk requires complex investigations multidisciplinary approach prompt therapy
technique image segmentation thresholding successfully utilized various image processing tasks paper novel generalized entropy handle additive nonextensive information exist physical system tunable entropic parameter introduced image segmentation new criterion thresholding algorithm based entropy described detail performance presented method compared classical entropy based thresholding methods state art methods experiments nondestructive testing images infrared images real images conducted experimental results show effectiveness proposed method
autism spectrum disorder asd characterized impairment social communication restricted repetitive interests included diagnostic characterization aspects face processing learning shown disruptions stages development asd although exact nature extent impairment vary age level functioning asd sample well task demands review examine nature face attention perception learning individuals asd focusing three broad age ranges early development middle childhood adolescence adulthood propose early delays basic face processing contribute atypical trajectory social communicative skills individuals asd contribute poor social learning throughout development face learning life long necessity social world individual broadens age thus addressing source impairment asd well trajectory ability throughout lifespan targeted treatments may serve positively impact lives individuals struggle social information understanding
objective evidence based therapies borderline personality disorder bpd lengthy scarce data brief interventions limited role treatment bpd unclear aim therefore evaluate clinical effectiveness brief dialectical behaviour therapy dbt skills training adjunctive intervention high suicide risk patients bpd method eighty four patients randomized weeks dbt skills waitlist primary outcome frequency suicidal non suicidal self injurious nssi episodes assessments conducted baseline weeks results dbt participants showed greater reductions participants suicidal nssi behaviours baseline weeks dbt participants showed greater improvements controls measures anger distress tolerance emotion regulation weeks conclusions abbreviated intervention viable option may useful adjunctive intervention treatment high risk behaviour associated acute phase bpd
traditional chinese herbal drugs used thousands years chinese pharmacopoeia bark magnolia officinalis rehder wilson known pinyin name houpo traditionally used chinese japanese medicines treatment anxiety asthma depression gastrointestinal disorders headache moreover magnolia bark extract major constituent currently marketed dietary supplements cosmetic products much pharmacological activity reported herb major compounds notably antioxidant anti inflammatory antibiotic antispasmodic effects however mechanisms underlying elucidated clinical trials published vitro vivo toxicity studies also published indicate intriguing features present review aims summarize literature officinalis bark composition utilisation pharmacology safety
backgroundsingle tooth replacement often requires prefabricated dental implant customized crown benefits individualization abutment remain unclear purposethis randomized controlled clinical trial aims study potential benefits individualization zirconia implant abutments respect preservation marginal bone level several clinical patient based outcome measures material methodsfifty participants missing premolar included randomly assigned standard zirdesign dentsplysirona implants molndal sweden computer aided design computer aided manufacturing cad cam customized atlantis dentsplysirona implants molndal sweden zirconia abutment therapy peri implant bone level primary outcome plaque index calculus formation bleeding probing gingiva index probing pocket depth recession appearance soft tissues patients contentment assessed shortly placement one year later resultsno implants lost complications related abutments observed statistically significant differences stock cad cam customized zirconia abutments could demonstrated operationalized variables conclusionthe use cad cam customized zirconia abutment single tooth replacement premolar associated improvement clinical performance patients contentment compared use stock zirconia abutment
wrought iron suspension footbridge built wissekerke castle kruibeke belgium oldest surviving chain footbridge continental europe footbridge shifted private public use condition footbridge surveyed assessed restoration works started winter new construction details revealed original foundation excavated giving insight applied anchorage system suspension cable iron bridge blast cleaned revealing connections uncovering assembly production stamps new findings broaden insight construction wissekerke footbridge also contribute overall knowledge early construction wrought iron
purposethe aim study describe detail characteristics accreditation compliance laboratories united states applying intersocietal accreditation commission iac transcranial doppler tcd accreditation methodsthis retrospective study applicant laboratories used iac database extract laboratory characteristics guideline compliance metrics resultsevaluation laboratories demonstrated hospital based located south corresponding location stroke belt states cases interpreting physicians neurologists evaluated accreditation process established practice common training pathway majority obtained additional vascular interpretation credential case studies frequent indications subarachnoid hemorrhage stroke carotid stenosis although laboratories previously accredited accreditation delayed due incomplete studies discrepant findings report laboratory diagnostic criteria discrepant findings report waveforms images conclusionsthe results suggest significant differences iac applicant laboratories laboratories represented centers medicaid medicare services cms claims data addition accurate study reporting physician training ongoing quality improvement activities may optimized laboratories applying accreditation information learned study educational strategies professional organizations including iac tailored help improve tcd practice
study examined role perceived procedural justice ppj plays conflict management behaviors intimate spouses adopt endorse context ppj defined degree one perceives spouse makes decisions fairly considerately participatory manner test impact perceived procedural justice conflict resolution behavior applied dual concern model conflict management style experiment participants read fictional scenarios predicted spouses responses found perceptions strong ppj enhanced prediction integrating problem solving compromising lesser degree obliging behavior perceived procedural justice also caused reduction avoidance behavior effect found dominating competing behavior following correlational study also found ppj positively correlated enhanced integrating compromising obliging behaviors correlations partially fully mediated degree dyadic adjustment measure relationship health addition second study found correlation perceived procedural justice dominating avoiding behavior studies participants either predicted chose collaborative behaviors non collaborative ones conclude perception one partner behaving procedurally way enhance active egalitarian collaboration marriage intimate partner relationships absence ppj seem encourage active non collaboration particularly highly self centered dominating behavior
serine acts endogenous agonist methyl aspartate receptors synapses making essential proper brain development function amino acid also linked several neurodegenerative diseases alzheimer disease dementia nevertheless primary site mechanism serine release remains unclear recently demonstrated use enzymatic amperometric biosensor invivo quantification endogenous serine release xenopus laevis tadpoles herein investigate effect permselective poly meta phenylenediamine electropolymerization conditions biosensor response time selectivity scanning electrochemical microscopy secm used optimized biosensor measure localized release serine model system secm methodology provides high spatial temporal resolution could useful investigate primary site mechanism serine release biological samples
turbulent wake generic space launcher wind tunnel model underexpanded nozzle jet investigated experimentally numerically gain insight variation intricate wake flow phenomena space vehicles higher stages flight trajectory increasing mach number experiments carried infinity infinity ludwieg tube test facility institute fluid mechanics technische universitat braunschweig corresponding time resolved computations performed institute aerodynamics rwth aachen university using zonal rans les approach strong alteration wake topology increasing mach number due changing pressure ratio nozzle exit found infinity moderate underexpansion rate infinity approximate leads formation recirculation region elongated triangular cross section reaching nozzle exit infinity substantially stronger afterexpansion jet plume infinity approximate causes formation cavity region quadrangular cross section stronger deflection towards nozzle infinity results lower mean rms wall pressure ratios infinity however due higher freestream pressure value lower mach number relation absolute values reciprocal making lower supersonic regime critical respect dynamic structural loads observation confirmed overall good agreement numerical experimental data characteristic positions base nozzle wall furthermore shown undesired effects strut support wake present along whole circumference infinity strut influence found particularly intense spectral analysis wall pressure fluctuations reveals fundamental differences dynamic behavior two investigated wake flow regimes infinity dominant frequency range around approximate associated inner dynamics recirculation bubble found base nozzle broad band low frequency content substantially higher amplitudes detected footprint graduate realignment turbulent shear layer along nozzle wall spectra infinity characterized several high frequency sharp peaks strong correlation supported wind tunnel configuration axisymmetric free flight case found peaks approximate known caused radial flapping motion shear layer along cavity
paper analyses influence different perforated solar screens pss annual daylight conditions expressed using climate based daylight metrics pss design require parametric studies often complex time consuming due large number simulations hence new methodology proposed optimize pss design applying design experiments using orthogonal arrays doa case study doa perspective conducted involves office space seville spain goal assess effect following pss design variables daylighting performance perforation percentage matrix shape orientation doa results reveal optimized pss increase daylit area reduce lit area compared reference models pss doa method reduces number simulations required could save time initial stages building design
one health emerging concept stresses linkages human animal environmental health well need interdisciplinary communication collaboration address health issues including emerging zoonotic diseases climate change impacts human animal bond promotes complex problem solving using systems framework considers interactions humans animals shared environment many medical educators may yet familiar concept one health approach endorsed number major medical public health organizations beginning implemented number medical schools research setting one health opens new avenues understand detect prevent emerging infectious diseases also conduct translational studies across species clinical setting one health provides practical ways incorporate environmental animal contact considerations patient care paper reviews clinical research aspects one health approach illustrative case updating biopsychosocial model proposes basic set one health competencies training education human health care providers
objectivespopulation based studies reported increased incidence skin cancer patients essential thrombocythemia polycythemia vera examined risk factors non melanoma skin cancer nmsc patients diagnosed methodsa case control study performed compare clinical treatment related data patients nmsc patients also evaluated whether polymorphisms genes involved dna integrity predisposed nmsc resultsby multivariate logistic regression analysis risk factors nmsc older age male sex higher cumulated hydroxycarbamide dose busulphan exposure time event prognostic model factors independently associated increased cumulative incidence nmsc age increased risk per year male sex increased risk hydroxycarbamide exposure increased risk susceptibility gene variant identified conclusionsthese findings suggest risk develop nmsc patients results combined effect common risk factors age male sex together cytoreductive treatment
paper presents spherical joint actuator using electrorheological fluid make new haptic master applicable robot assisted cutting surgery proposed haptic master consists two actuators different motions spherical joint device dof rotational motion linear device dof translational motion appropriate size haptic master designed based governing equations dynamic model manufactured haptic master connected slave robot cutting surgery tissue surgical process forces required cut tissue pork work obtained using force sensor via experimets used desired forces tracked slave robot controlled proportional integrative derivative pid controller desired repulsive forces embodied haptic master operator feel forces occurred cutting process actual forces order validate effectiveness proposed haptic master tracking control performances desired force actual force evaluated time domain elsevier rights reserved
locating virtual machines improves utilization resource shared environments resulting performance interference vms difficult model predict qos sensitive applications suffer resource location less short term resource sensitive batch applications common practice overprovisioning resources helps avoid performance interference guarantee qos leads low machine utilization recent work relies static approaches suffer practical limitations due assumptions priori knowledge application behaviour workload address limitations present stay away generic adaptive mechanism mitigate detrimental effects performance interference sensitive applications located batch applications mechanism complements allocation decisions resource schedulers continuously learning favourable unfavourable states execution mapping state space representation trajectories representation used predict prevent transition towards interference sensitive applications proactively throttling execution batch applications representation also doubles template prevent violations future execution repeatable sensitive application located batch applications experimental results realistic applications show possible guarantee high level qos latency sensitive applications also improving machine utilization
background aimsdysfunction brain regions underlying impulse control reward processing executive function associated previously adolescent alcohol misuse however identifying pre existing neurobiological risk factors distinct changes arising early alcohol use difficult outline neuroimaging data identify neural predictors adolescent alcohol use initiation misuse using prospective longitudinal studies follow initially alcohol naive individuals time neuroimaging adolescents inherited risk factors alcohol misuse methoda comprehensive narrative literature regarding neuroimaging studies published focusing predictors adolescent alcohol use initiation misuse findingsprospective longitudinal neuroimaging studies identified pre existing differences adolescents remained alcohol naive transitioned subsequently alcohol use functional structural grey matter differences observed temporal frontal regions including reduced brain activity superior frontal gyrus temporal lobe thinner temporal cortices future alcohol users interactions brain function genetic predispositions identified including significant association found ras protein specific guanine nucleotide releasing factor rasgrf gene reward related striatal functioning conclusionsneuroimaging predictors alcohol use shown modest utility date future research use sample performance quantitative measure predictor utility neuroimaging data combined across multiple modalities including structural information volumetrics cortical thickness conjunction white matter tractography number relevant neurocognitive systems assayed particularly inhibitory control reward processing executive functioning combining rich magnetic resonance imaging data set could permit generation neuroimaging risk scores could potentially yield targeted interventions
recognized individuals autism spectrum disorder asd show discrepancies abstract capacities solve social cognition dilemmas ability spontaneously decipher live social interactions last years different paradigms designed investigate individuals asd grasp information emerged naturalistic live social interactions present paper reviews three categories paradigms focus verbal questionnaires interviews participants view naturalistic social scenario eye tracking methods participants view naturalistic settings simulation social interactions using virtual reality robotics paper discusses advantages limitations paradigm suggests new concept combining paradigms
platelets actively participate inflammatory processes drive diseases atherosclerosis rheumatoid arthritis cancer metastasis however platelets also anti inflammatory anti infective properties received less consideration past review highlight recent findings role platelets host defense describe regulatory pathways modulating immune responses furthermore discuss role platelets resolution inflammation tissue repair conceptual changes contribute understanding platelet biology disease
letter propose novel method unsupervised change detection multitemporal multispectral landsat images using multiobjective evolutionary algorithm moea proposed method minimizes two different objective functions using moea provide tradeoff objective functions used evaluating changed unchanged regions difference image separately difference image obtained using structural similarity index measure method provides combination comparisons luminance contrast structure two images evolving population solutions moea set pareto optimal solution estimated single run find best solution markov random field fusion approach used experiments semisynthetic real world data sets show efficiency effectiveness proposed method
longitudinal cross sectional profiles alluvial channels altered presence seepage however available literature suggests seepage considered analyses bank profiles threshold alluvial channels experimental study reported downward seepage applied parabolic channels based tractive force theory order determine effect longitudinal cross sectional profiles observed sediment transport threshold channels increased downward seepage applied parabolic shape hold channels formed new cross sectional shape flat bed two curved banks achieved stability reason increased sediment transport threshold channel application downward seepage sought analysing time averaged velocities empirically derived exponential expression developed bank profiles threshold alluvial channels affected seepage relationship among hydraulic parameters stable channel downward seepage also suggested basis experimental observations
aimswe evaluated long term efficacy safety combination therapy anticholinergic agent blocker patients benign prostatic enlargement bpe complaining voiding overactive bladder oab symptoms comparison blocker monotherapy conducting urodynamic study uds methodsthis randomized prospective study involving outpatients untreated bpe associated urinary urgency least per week oabss patients randomly assigned receive silodosin day silodosin day propiverine day changes parameters baseline weeks year administration assessed based ipss ipss qol oabss voiding storage functions measured uds resultsin efficacy analysis patients included although mean ipss oabss significantly improved groups group showed statistically significant improvement oabss ipss qol oab urgency score long term evaluation storage function groups showed significant improvements group demonstrated greater improvement terms disappearance rate detrusor overactivity bladder capacity conclusionslong term combination treatment silodosin propiverine effective safe bpe patients voiding oab symptoms neurourol urodynam wiley periodicals inc
medicare part program introduced prescription drug coverage seniors examine impact program use emergency department care using difference differences model find declines number visits non emergency care emergency care suggesting part may led better management health reduced unnecessary use eds copyright john wiley sons ltd
genetic mutations underlying neurodegenerative disorders impair ribosomal dna rdna transcription suggesting nucleolar dysfunction could novel pathomechanism polyglutamine diseases certain forms amyotrophic lateral sclerosis frontotemporal dementia investigated nucleolar activity pre symptomatic digenic models parkinson disease model multifactorial aetiology disease end analysed novel mouse model mildly overexpressing mutant human alpha synuclein hat snca pten induced kinase pink park knockout background mutant mice lacking also known park pink showed overexpressed hat snca localizes nucleolus moreover mutants show progressive reduction rdna transcription linked reduced mouse lifespan contrast rdna transcription preserved pink double knockout dko mice mrna levels nucleolar transcription initiation factor tif also known rrn decrease substantia nigra individuals loss tif tool mimic nucleolar stress increases oxidative stress pink mutations result higher vulnerability oxidative stress explored synergism associated genes impaired nucleolar function conditional ablation tif blocked ribosomal rna rrna synthesis adult dopaminergic neurons pink dko background however early phenotype triple knockout mice similar mice exclusively lacking tif data sustain model loss pink impair nucleolar activity pre symptomatic stage first study analyse nucleolar function digenic models conclude least models nucleolus severely disrupted previously shown neurons patients neurotoxin based mouse models results also show early increase rdna transcription nucleolar integrity may represent specific homeostatic responses digenic pre symptomatic models
study bivo prepared hydrothermal synthesis route presence sodium dodecyl sulfate using aqueous precipitant prepared combustion method using melamine order develop highly efficient photocatalyst heterojunction catalyst based bivo prepared different amounts bivo mixed annealed obtain heterojunction photocatalysts fevo lavo also prepared comparative catalytic investigation catalysts characterized series complementary combinations powder ray diffraction thermogravimetric analysis elemental analysis adsorption desorption scanning electron microscopy transmission electron microscopy temperature programmed desorption diffuse reflectance ultraviolet visible spectroscopy ray photoelectron spectroscopy photoluminescence spectroscopy photoelectrochemical studies catalysts investigated visible light driven oxidation benzyl alcohol benzyl amine aniline order propose electrons holes radicals mediated reaction pathways reactions performed presence electron hole radical scavenger order confirm various products formed photocatalytic oxidation benzyl alcohol benzyl amine aniline several model reactions carried based results obtained reaction mechanism structure activity relationship established
compensation hysteresis nonlinearities smart material based actuators presents challenging task applications many approaches proposed literature including inverse multiplicative scheme advantage scheme avoid direct model inversions however approach mainly developed bouc wen model focusing preisach model utilized describe magnetostrictive actuators paper inverse compensation approach preisach model using inverse multiplicative structure developed since input signal implicitly involved preisach model imposes great challenge construct inverse function model obtain explicit expression input signal implicit form inverse multiplicative technique applied preisach model decomposed non memory part memory part using separation requires solve inverse non memory part obtain explicit expression input signal thus avoiding constructing inverse entire complex dual integral formulation preisach model experimental results magnetostrictive actuator demonstrate effectiveness proposed approach
synaesthetic projection augmented reality cropping futuristic display technology empowers advance human interaction high quality projected images free space order make ubiquitous displays attainable conspicuous low cost user tracking solutions required novel walk design allows users literally get hands immaterial display interact augmented world proposed system android operating system based mobile phone device connected wirelessly immaterial screen device creating optical see display free space advanced user interactions thereby creating ambient intelligence produced augmenting physical world around digital information
article describes examination sociodemographic characteristics adult children particularly baby boomer caregivers provide financial care older parents dementia sample including adult children dementia caregivers aged years selected nationally representative sample health retirement study exact logistic regression revealed race provision financial assistance caregiver children number children significantly associated financial caregiving parents non white caregivers likely provide financial care parents parents law dementia children provide financial assistance children less likely provide financial care parents dementia current findings present valuable new information sociodemographic characteristics adult children provide financial assistance parents dementia inform research programs services dementia caregiving
smart grids often analyzed using top approach starting communication control technologies evolution focus effects active passive users terms new services higher efficiency quality supply however bottom approach virtual power plants vpp promising instruments promoting effective integration distributed generation energy storage devices well valid means enabling consumers respond load management signals operated supervision scheduling coordinator aggregation factors profitable distributed energy resources ders economy energy network paper presents new algorithm optimize day ahead thermal electrical scheduling large scale vpp lsvpp contains many small scale producers consumers prosumers distributed large territory energy storage cogeneration processes algorithm also takes account actual location der public network specific capability thermal electrical generator models load storage devices detailed flexible rates incentives framework several novelties respect previous literature proposed case study results also described discussed
new quantum dialogue protocol designed using continuous variable two mode squeezed vacuum states due entanglement property two communication parties encode secret information entangled optical modes translation operations communication party could deduce secret information counterparts help secret information bell basis measurement results security proposed quantum dialogue protocol guaranteed correlation two mode squeezed vacuum states decoy states performed translation operations randomly selected time slots compared discrete variable quantum dialogue protocols proposed continuous variable quantum dialogue protocol easy realize perfect utilization quantum bits
conveyor belt one common types continuous handling equipment used moving rocks various sizes horizontally inclined researches done exploitation mineral resources rocks strength materials calculations paper observed conveyor sizing elements transporter requires knowing belt traction forces tensions thereof varies conveyor length cases operation conveyor belt must provided without engaging slip phenomenon limiting displacement sets rollers conveyor operating optimum parameters materials make conveyor belt divided two categories materials coating plates outer shell resistance part areas inserts textile steel cables bands subjected tensile efforts wear phenomena determine maximum strength operate without going permanent deformation regime conveyor belt dimensioning calculations elements conveyor varies depending length carrier operating situations see also sizing conveyor belt conveyor components require knowledge belt traction forces tensions thereof varies along length conveyor tensions conveyor belt study climb section descend section mentions specific resistance motion belt full branch consisting resistances due current material deformation rotation rollers camps pressing rubber layer roll belt belt bending since current material strength due deformation bending belt represents large percentage total specific resistance motion follows resistance decreases decreasing displacement belt rollers increase effort belt respectively explains resistance decreases increasing length conveyor especially initial stretch great increasing conveyor tilt also observe values forces calculated paper resistance rotation roller bearings decreases increasing load roll hence values adopted specific resistance movement larger empty branch full knowing calculate resistances motion belt fix occur belt efforts points made contour method starting point drum motor development ending point winding movement resistances calculated empty full branches needed precisely determine installed power conveyor belt
background age related reduction bone mineral density bmd generally accelerated women menopause could even pronounced individuals sarcopenia light load power training low number repetitions would increase bmd significantly reducing bone loss individuals risk osteoporosis study investigated effects low repetition light load power training bmd japanese postmenopausal women sarcopenia methods training group followed progressive power training protocol increased load weighted vest two sessions per week course weeks training exercise comprised five kinds exercises squats front lunges side lunges calf raises toe raises exercise contained eight sets three repetitions rest set control group undergo training intervention measured bmd muscle strength anthropometric data results within group changes pelvis bmd knee extensor strength significantly greater training group control group pelvis bmd knee extensor strength respectively low repetition light load power training noted improvements pelvis bmd knee extensor strength significant within group differences observed anthropometric data forearm bmd conclusions six weeks low repetition light load power training improved pelvis bmd knee extensor strength postmenopausal women sarcopenia since training program require high load exercise therefore easily implementable daily exercise could effective form exercise sedentary adults risk osteoporosis fearful heavy loads training could cause fatigue
delivery products services construction based businesses increasingly becoming knowledge driven information intensive proliferation building information modelling bim increased business opportunities well introduced new challenges architectural engineering construction facilities management aec industry effective use sharing exchange building life cycle information knowledge management building design construction maintenance operation assumes position paramount importance paper identifies subset construction management relevant knowledge different design conditions building components critical comprehensive review synthesized literature information gathering knowledge acquisition techniques explores domain knowledge formalized ontologies subsequently query vocabulary order equip bim users capacity query digital models building retrieval useful relevant domain specific information formalized construction knowledge validated interviews domain experts relation four case study projects additionally retrospective analyses several design conditions used demonstrate soundness realism completeness appeal knowledge base query based reasoning approach relation state art tools solibri model checker navisworks knowledge engineering process methods applied research information representation retrieval could provide useful mechanisms leverage bim support number knowledge intensive tasks functions
clozapine atypical antipsychotic established treatment choice treatment resistant schizophrenia scz date study investigating comprehensive dna methylation changes scz patients treated chronic clozapine reported purpose present study reveal effects clozapine dna methylation treatment resistant scz conducted genome wide dna methylation profiling peripheral leukocytes cpg dinucleotides treatment resistant scz patients treated clozapine longitudinal study significant changes dna methylation observed sites one year treatment clozapine genes enriched cell substrate adhesion cell matrix adhesion gene ontology terms furthermore dna methylation changes crebbp creb binding protein gene significantly correlated clinical improvements findings provide insights action clozapine treatment resistant scz
wire arc additive manufacture waam twist wire robot movement result sudden changes wire feeding position thus cause deposition defects dimensional errors worst case may cause wire jamming damage wire feeding system therefore online monitoring correction wire deflection important waam paper vision based measuring method proposed detecting deviations wire feeding position plasma welding based waam process uses adaptive threshold hough transform extract wire edges judges merges coincident lines applies radon transform measure wire deflection software automatically detect wire deviation developed based proposed method method software verified experiments
dynamic contrast enhanced mri provides information heterogeneity synovium primary target disease children juvenile idiopathic arthritis jia evaluate feasibility dynamic contrast enhanced mri wrist children jia using conventional descriptive measures time intensity curve shape analysis explore association enhancement characteristics clinical disease status thirty two children jia wrist involvement underwent dynamic contrast enhanced mri movement registration classified using validated criteria clinically active inactive outcome measures included descriptive parameters classification time intensity curve shapes represent patterns signal intensity change time differences dynamic contrast enhanced mri outcome measures clinically active clinically inactive disease analyzed correlation juvenile arthritis disease activity score determined comprehensive evaluation disease status technically feasible quality dynamic dataset improved movement registration conventional descriptive measure maximum enhancement differed significantly clinically active inactive disease whereas time intensity curve shape analysis showed differences juvenile arthritis disease activity score correlated moderately enhancing volume dynamic contrast enhanced mri promising biomarker evaluating disease status children jia wrist involvement conventional descriptive dynamic contrast enhanced mri measures better associated clinically active disease time intensity curve shape analysis
purpose review article addresses three important topics part contemporary life children endocrine disruptors hazards international travel impact media violence children adolescents recent findings practitioners learn phthalates bisphenol endocrine disruptors published studies elevated phthalates associated increase pubertal gynecomastia premature thelarche bisphenol judged food drug administration concern potential effects brain behavior prostate gland fetuses infants young children hence decision take reasonable steps reduce exposure infants travel related diseases diarrheal disease primarily campylobacter salmonella dermatologic conditions animal bites systemic febrile illness malaria dengue fever respiratory illnesses predominate children adolescents spend using media per day degree media violence linked behavior conclusive prevention message practitioners important parents important mitigating effect summary endocrine disruptors travel related diseases media violence part modern day life children pediatricians need stay abreast recent findings access date resources assist providing contemporary advice guidance patients families
aims objectives assess women attitudes towards mechanisms action birth control methods backgroundwhen addressing women knowledge attitudes towards birth control methods researchers frequently focus side effects effectiveness correct use women opinions mechanisms action much less investigated research usually concentrated pill designcross sectional study methodswomen aged germany france sweden romania randomly selected asked whether would use method may work fertilisation implantation whether would continue using learning may effects logistic regression performed evaluate influence certain characteristics women attitudes resultsalmost half women romania germany would use methods postfertilisation effects lowest percentages found sweden france regarding methods postimplantation effects higher percentages found countries highly educated women using highly effective method likely use methods postfertilisation effects contrary married women stated human life begins fertilisation women middle high religiosity less likely consider using methods may act fertilisation conclusions one third european women reported would consider using method may postfertilisation effects relevance clinical practice given postfertilisation effects may acceptable women informing methods may effects essential obtaining complete informed consent promoting women autonomy
introduction objectives two objectives study examine effects introduction post event information correct incorrect memory central peripheral aspects given situation determine effects additional information level confidence claimed participants regarding reported memories method one hour half watching film participants presented three types information means open questions leading misleading neutral one week later carried recognition task assess extent sure answers results memory event accurate concerning central aspects event peripheral elements misinformation effect appeared central condition addition following presentation incorrect information participants certain answers related central aspects conclusion results highlight importance taking account centrality factor studies misinformation phenomenon elsevier masson sas rights reserved
chalcogenide glasses ges gas agi xla mol fabricated traditional melt quenching method effects addition las physical thermal optical properties glass system investigated results showed fabricated glasses possess considerably high glass transition temperature exhibit improved mechanical property excellent infrared transmission redshift visible absorbing cut edge observed increasing las content direct indirect optical band gap values also calculated raman spectra analysis indicated band decreased amplitude new peak detected manifesting formation bond network addition mid infrared emission glasses doped ions achieved results indicated glasses promising materials mid infrared applications imaging remote sensing lasers
article presents embedded active vibration suppression system featuring real time explicit model predictive control empc implemented microcontroller unit mcu empc controller minimizes tip deflection aluminum cantilever beam driven piezoceramic actuators gaining feedback direct position measurements output input performance empc method compared analogously tuned positive position feedback ppf controller extensive analysis provided cycle timing memory needs explicit predictive vibration control scheme results demonstrate empc controller may achieve vibration suppression results compared ppf less input effort inherently respecting process constraints furthermore show empc task execution timing comparable random access memory ram read memory rom alternatives suggesting numerous current microcontrollers suitable empc based active vibration control case prediction model kept simple elsevier ltd rights reserved
ever growing geriatric population research brain diseases dementia imperative ever prevalent dementias alzheimer disease progressive neurodegenerative disease presents deficits memory cognition motor skills general decline quality life social economic burden associated alzheimer disease tremendous projected grow even greater coming years specific need elucidate improve treatments available alleviate symptoms related dementias alzheimer also prevent formation disease effort expedited made efficient utilizing animal model zebrafish paper reviews utility zebrafish alzheimer research examining research sampling treatments available disease specifically donepezil memantine methylene blue human model shortcomings rodent model also discussed wolters kluwer health inc rights reserved
background little known gender difference correlates antisocial personality disorder aspd among drug users objective detect gender difference correlates aspd chinese heroin dependent sample methods structured interviews conducted among heroin dependent users two compulsory isolation settings changsha china descriptive statistics employed report sample characteristics gender bivariate relationships examined occurring aspd variables measuring demographic drug use psychiatric morbidities multivariate logistic regressions stepwise forward method conducted determine independent predictors occurring aspd analyses examining correlates occurring aspd conducted total male female participants respectively detect common unique correlates aspd gender results total participants males females met dsm criteria aspd male participants lower educational level unemployment unmarried younger age first heroin use previous history compulsory treatment larger amounts heroin used per day poly drug abuse past month admission well psychiatric morbidities lifetime major depressive disorder borderline personality disorder independent predictors occurring aspd female participants three variables younger age first heroin use paranoid personality disorder borderline personality disorder independent predictors occurring aspd conclusions gender differences prevalence correlates aspd among heroin dependent users detected findings highlight need gender specific interventions elsevier ltd rights reserved
chitinthe second abundant organic material earthis polysaccharide combines proteinaceous materials form composites provide structural backbone insect cuticles crustacean exoskeletons cephalopod shells covering surfaces many living organisms although chitin related chitosan materials used various industrial medical applications based chemical properties unique mechanical functions date leveraged commercial applications use chitinous materials structural applications limited inability reproduce even fully understand complex hierarchical designs behind naturally occurring chitin composites article example engineered chitinous materials used introduce reader potential value bioinspired materials offer engineering synthetic biological materials nature chitin general characteristics first reviewed examples chitinous structures presented designed perform different functions nacre insect cuticle investigation structural organization materials leads understanding principles natural materials design beginning harnessed fabricate biologically inspired composites materials engineering tunable properties mimic living materials might provide useful environmental challenges well medical applications
law governing assisted conception united kingdom human fertilisation embryology act mandates section clinicians make child welfare assessments proceeding treatment act section stated assessment take account need father section revised human fertilisation embryologyact words father replaced supportive parenting order signal official recognition sex parents article challenges idea might seen unequivocally progressive development reference growing body scholarship critically evaluates attention policy makers come pay parenting discusses sociopolitical context gave rise section pressures led reform findings interview study members staff work assisted conception clinics discussed focusing staff perceptions new policy meanings ascribe term supportive parenting opinions responsibility given law child welfare article concludes professionals understandings role resonate strongly wider realities oversight parent child relations considered characteristic policies parenting
research examines victim offender characteristics well contextual factors related lethality assaults children less years old national incident based reporting system nibrs data analyzed using logistic regression techniques estimate two models designed explore factors associated death preschoolers results indicate probability fatality significantly influenced victim offender characteristics victim offender relationship weapon used time incident region united states incident occurred
recent years software engineering researchers recognized importance role theory research resulting emergence general theories software engineering gtse community editorial introduces special section contains four articles reflects advances made contributing authors discuss different approaches taken four papers outline number avenues future research elsevier rights reserved
objective evaluate reduction thrombotic events patients essential thrombocythaemia treated anagrelide versus hydroxyurea aspirin asa methods questionnaire developed using diagnostic criteria thrombotic risk factors stratified according landolfi criteria questionnaire completion clinicians hungarian haematological centres entered data hungarian mpn registry patients myeloproliferative neoplasms based registry data tes anagrelide treated patients compared asa treated patients results patients followed median tes reported significantly fewer anagrelide treated patients versus asa versus numbers major arterial major venous events similar groups although fivefold minor arterial minor venous events asa group median age diagnosis older length follow shorter asa group influence incidence medication diagnosis influenced incidence conclusions anagrelide significantly decreased number patients experiencing minor arterial minor venous tes versus asa risk diagnosis significantly increased patient diagnosis
hereditary angioedema hae due esterase inhibitor inh deficiency hae inh rare medically significant disease associated considerable morbidity mortality research pathogenesis hae inh expanded greatly last six decades led new clinical trials novel therapeutic agents treatment strategies mechanisms pharmacotherapy include supplementing inh missing serine protease inhibitor hae inhibiting activation contact system uncontrolled release proteases kallikrein kinin system blocking production function components inhibiting fibrinolytic system blocking production function components inhibiting function bradykinin endothelial level strategies managing hae inh aimed treating acute attacks preventing attacks use prophylactic treatment available agents treating acute attacks include plasma derived inh concentrates recombinant inh bradykinin receptor antagonist plasma kallikrein inhibitor long term prophylactic treatments include attenuated androgens plasma derived inh concentrates anti fibrinolytics plasma derived inh bradykinin receptor antagonist already approved self administration home number management options hae inh increased considerably within past decade thus helping alleviate burden rare disease
bone mineral density bmd suggested associated atherosclerosis present study evaluated association lumbar bmd segments carotid intima media thickness cimt surrogate marker subclinical atherosclerosis korean adults consideration sex menopause status among korean adults enrolled healthy twin study men premenopausal women postmenopausal women measured cimt common carotid artery intimamedia thickness cca imt carotid bifurcation intima media thickness bif imt internal carotid artery intima media thickness ica imt using mode ultrasound lumbar bmd using dual energy ray absorptiometry composite cimt calculated mean value three cimts association evaluated using linear mixed models premenopausal women lumbar bmd positively associated composite cimt cca imt respectively however association observed bmd cimt men postmenopausal women stratified analysis revealed effect body mass index bmi association bmd cime positive association premenopausal women persisted low bmi group men high lumbar bmd may indicate elevated risk subclinical atherosclerosis premenopausal women men high bmi
lexicographic preferences set attributes provide cognitively plausible structure modeling behavior human decision makers therefore induction corresponding models revealed preferences observed decisions constitutes interesting problem machine learning point view paper introduce learning algorithm inducing generalized lexicographic preference models given set training data consists pairwise comparisons objects approach generalizes simple lexicographic orders sense allowing model consider several attributes simultaneously instead looking one one thereby significantly increasing expressiveness model class order evaluate method present case study highly complex real world problem namely choice recognition method actuarial gains losses occupational pension schemes using unique sample european companies problem well suited demonstrating effectiveness lexicographic ranker furthermore conduct series experiments benchmark data machine learning domain elsevier rights reserved
background effect hepatitis virus hcv coinfection cell recovery treated hiv infected children poorly understood objective compare cell recovery hiv hcv coinfected children recovery hiv monoinfected children method studied hiv monoinfected hiv hcv coinfected children receiving antiretroviral therapy art median follow period years interquartile range years dataset came ukraine pediatric hiv cohort hiv hcv coinfection study within european pregnancy paediatric hiv cohort collaboration fitted asymptotic nonlinear mixed effects model cell reconstitution age standardized counts children investigated factors predicting speed extent recovery results found significant impact hcv coinfection either preart long term age adjusted counts scores however rate increase score slower hiv hcv coinfected children compared monoinfected counterparts monoinfected coinfected children starting art younger ages higher preart long term scores started older conclusions hiv hcv coinfected children receiving art slower cell recovery hiv monoinfected children hiv hcv coinfection impact pre art long term scores early treatment hiv hcv coinfected children art encouraged
achieving efficient security solutions wireless sensor networks wsn daring challenge due vulnerable nature wireless medium routing major threat security adversary inject bogus routing route nodes causing false decision drain sensors energy network system identify prune adversaries pruning route modifiers prm algorithm based collaborative authentication system proposed algorithm considers random deployment sensor nodes based collaborative authentication scheme prm algorithm save energy pruning malicious nodes early stage simulation results theoretical analysis reveals prm algorithm effective terms efficient secure routing algorithm reduces consumption energy pruning establishes shortest path leads efficient network enables security
air particulate matter important component air pollution reported play important role adverse health effects latter extensive experimental data epidemiological studies shown increased cardiovascular morbidity mortality atherosclerosis caused air pollution mainly due component implicated adverse health effects ability induce oxidative stress pro inflammatory events vascular system association cardiovascular ischemic events atherosclerosis induced linked ultrafine fine components particles high content redox cyclic chemicals together ability combine proatherogenic molecules enhanced tissue oxidative stress studies shown oxidative stress induced could regulates expression phase phase metabolize enzymes regulation occurs activation transcription factors nuclear factor erythroid derived like related factor nrf aryl hydrocarbon receptor ahr review focus data supporting role oxidative stress inflammation induced cardiovascular diseases atherosclerosis importance nrf ahr dependent regulatory pathways induced cardiovascular events atherosclerosis elsevier rights reserved
background emergency contraception widely accepted safe method preventing conception following unprotected coitus use promoted south africa yet uptake among women appears remain low aim aim study access knowledge use among women presenting termination pregnancy district hospital kwazulu natal methods hospital based cross sectional study data collected women attending termination pregnancy top service district hospital using questionnaire analysed descriptively results total women participated years age single reported knowledge good participants indicating knew however knowledge around complete less knowing time interval intercourse action believing acted inducing abortion reported usage conclusion study revealed much done enhance knowledge use context reasons discrepancy knowledge usage need exploration
introduction thyroid disorders known risk factor cardiovascular diseases epicardial fat thickness eft oxidative stress also believed major risk factors cardiovascular events aim study evaluate possible relationship oxidative stress parameters eft patients subclinical hypothyroidism sch material methods total individuals patients sch healthy controls recruited study eft oxidative stress parameters participants analyzed baseline analyzed sch patients achievement euthyroid state results compared healthy subjects sch patients significantly higher eft oxidative stress parameters eft oxidative stress parameters decreased treatment decrease eft levels statistically significant thyroid hormone replacement serum eft levels significantly correlated oxidative stress index conclusions previous studies demonstrated visceral adipose tissue oxidative stress major risk factors cardiovascular events study demonstrated eft visceral adipose tissue oxidative stress parameters higher could used indicator cardiovascular diseases patients sch
crohn disease one major subtypes idiopathic inflammatory bowel disease characterized chronic transmural intestinal inflammation gastrointestinal tract anywhere mouth anus predilection small bowel cross sectional imaging computed tomography magnetic resonance enterography plays key role confirming diagnosis identifying managing complications assessing disease severity identifying response medical therapy review focus role radiologists diagnosis assessment crohn disease additionally review current medical therapy approaches available medications side effects discussed review also highlight key complications medical therapy associated diseases evaluated radiologist cross sectional imaging
past mentally ill used relentlessly stigmatized basic needs grossly neglected china coastal cities western oriented universities provided western type mental healthcare general traditional chinese medicine tcm embracing medicinal herbs acupuncture practiced mental hospitals non existent care chronically mentally ill rested families community however prevalence spectrum mental disorders similar western countries establishment people republic china old fashioned mental hospitals founded great leap forward starting envisaged creation mental healthcare system based soviet union standards psychiatry strong biological orientation psychotherapy exist psychology rejected science taught universities reform opening policy education psychology stepped psychology introduced academic discipline psychotherapy psychosomatic medicine established mental healthcare current mental healthcare china resembles standard germany psychiatrie enquete expert commission official report mental health act adopted years planning china laid legal foundation planning establishing humane system mental healthcare act safeguards patients human individual rights increases trust psychiatric institutions guarantees right optimal treatment provides legal protection cases malpractice
paper present efficient algorithm computing discrete cosine transform dct first arrange input data matrix certain order second formulate output data matrix block structured matrix vector multiplication show block structured matrix properties dct kernel matrix therefore dct problem reduced dct problem thus provide procedure computing dct similar dct primary appeal algorithm lies low computational cost also regular structure transform size increases
paper multi mode parallel hybrid power train called clutchless geared smart transmission cgst proposed assessed terms fuel economy use single motor generator planetary gear enables cgst provide remarkable flexibility four operational modes including parallel hybrid mode based novel configuration fuel consumption model newly developed simulated analyze fuel economy cgst performance cgst compared power split hybrid system conventional manual transmission city highway cycles cgst shows best efficiency highway driving reducing unnecessary energy loss electric motor moreover thanks brake regeneration efficient engine operation specific operational modes fuel economy city cycle comparable power split hybrid system even though cgst uses single electric motor
backgroundthe aim study investigate association congenital heart disease chd serum ghrelin tumor necrosis factor tnf interleukin methodsixty three children chd hospitalized january september wuhan women children health care center selected study group additionally healthy individuals physical examinations hospital selected control group enzyme linked immunosorbent assay elisa used measure serum ghrelin tnf spss comprehensive meta analysis used data analysis resultsthere significant difference weight height body mass index bmi cyanotic chd cchd acyanotic chd achd control groups one way analysis variance serum ghrelin tnf cchd achd groups tendency higher compared control group whereas pearson correlation analysis correlation serum ghrelin bmi tnf negatively positively correlated bmi meta analysis demonstrated serum ghrelin tnf cchd achd groups higher control group conclusionserum ghrelin tnf elevated children chd may play role development progression chd
case polycythemia vera associated immunoglobulin nephropathy igan year old woman described literature search associated renal disease also conducted reported myeloproliferative neoplasms may play role development glomerular diseases jak mutation plays role pathogenesis myeloproliferative neoplasms may therefore also responsible association
purpose determine availability emergency contraception rural urban pharmacies kansas methods sample kansas pharmacies selected using random integer generator measured ability dispense within hours whether stock time survey call examined availability based geographic differences pharmacy type findings sample pharmacists agreed interviewed unable provide within hours essentially differences availability rural could dispense hours urban pharmacies could dispense hours corporate pharmacies likely able provide within hours compared independent pharmacies thirty one percent pharmacists carry time survey call sample urban pharmacies twice likely report carrying compared rural pharmacies corporate pharmacies also likely report carrying compared independent pharmacies conclusions sample kansas pharmacies differences rural urban pharmacies hour availability however differences stocked time survey call corporate pharmacies likely dispense within hours stock compared independent pharmacies suggesting differences availability
nonconscious mimicry salient behaviour many social interactions imitation accent phone tendency return smile another smiling person however existing research yet consider importance individuals social intentions entering social interaction customer service setting paper extends current managerial leadership theory novel setting nonconscious mimicry explain critical role social intentions relationship building customer service encounters research consists subjects factorial design evaluate hypothesised relationships nonconscious mimicry social intentions product choice behaviour findings indicate social intentions play critical role influencing relationship nonconscious mimicry product consumption purchase intentions product liking service encounters suggested individuals identified task oriented behaviourally imitated positively increase product liking purchase intentions product consumption instead consumers primed relationship oriented prior nonconscious mimicry australian new zealand marketing academy published elsevier ltd rights reserved
purpose purpose paper explore rank benefits barriers technological non technological using building information modelling bim sustainable building design also employs use design tool analysis case study using bim compatible tools ecotect green building studio determine environmental performance proposed multi use building derby north design methodology approach paper explores benefits barriers using bim literature review regression factor analysis used rank benefits barriers questionnaire distributed sample practitioners completing survey finally paper employs use design tool analysis case study using bim compatible tools ecotect green building studio determine environmental performance proposed multi use building derby north riverside findings key findings statistical analysis indicated professionals ranked integrated project delivery established benefit lack interoperability ranked greatest technological challenge three attributes non technological challenges made statistically unique contributions namely training costs software costs client demand potential legal issues also discovered bim delivers information needed environmental performance forward looking approach paper attempts provide recommendations would encourage continuous application bim sustainable building design research limitations implications paper cover features bim functionality scope bim enormous resources research limited practical implications implication study assist exploring ranking benefits barriers technological non technological using bim proffering recommendations future use research interest industry practitioners academic researchers interest building information modelling originality value paper contributes new outlooks aimed syndicating sustainability environmental performance adds limited empirical studies benefits barriers application bim
paper introduces novel approach measurement process planning machine tool assembly applying observability principle state space model widely used control engineering initially state space modeling carried describing variation propagation accumulation assembly process mathematical explanation measurement uncertainty accumulation presented means optimal estimation using kalman filter based analysis algorithm developed find optimal solution small estimation errors money working time costs provide designers feasible measurement plans assembly method used quantitative approach could offered evaluation uncertainties measurement process totally different traditional methods dependent experiences suggested approach finally applied assembly horizontal machining center numerical analyses conducted validate proposed method guidance measurement planning summarized example analysis elsevier inc rights reserved
growing evidence members cytochrome enzymes contribute regulation normal prenatal development cyp epoxygenases cypc cypj subfamilies convert arachidonic acid four regioisomeric epoxyeicosatrienoic acids eets biologically active molecules involved mitogenesis cell signaling almost nothing known localization expression tissues human prenatal development spatio temporal expression pattern cypc cypc cypc cypj human embryonic fetal intestines liver kidney investigated immunohistochemical method cyp epoxygenases expressed already early stages development embryonic fetal tissues early week iud intestines week iud liver week iud kidney kidney cyp epoxygenases expressed metanephrogenic blastema uninduced mesenchyme tubular system intestines diverse cyp epoxygenases distribution along crypt villus axis could suggest role cell differentiation moreover detected higher cypj level organs adult tissue samples
present two new matrix spectral problems construct corresponding soliton hierarchies levi type aid symbolic computation maple hamiltonian structures resulting soliton hierarchies obtained means trace identity thus shown soliton hierarchies liouville integrable elsevier rights reserved
examine six chronic diseases cause mortality among immigrants israel areas contaminated chernobyl accident medical data obtained two largest hmos israel assessment chronic diseases individuals divided three groups less exposed exposed liquidators mortality analysis two groups less exposed exposed compared less exposed adults exposed group increased odds respiratory disorders elevated odds borderline significance ischemic heart disease addition liquidators increased odds hypertension compared less exposed cox proportional hazards model indicated difference ratio cause mortality exposed groups follow period study conducted approximately two decades accident suggests exposure radionuclides may associated increased odds respiratory disorders hypertension
event sequences estimation important issue fault diagnosis des far fault events directly measured work event sequences estimation petri net models events assumed represented transitions firing sequences estimated measurements marking variation estimation without measurement errors discussed dimensional vector space alphabet sufficient conditions estimation algorithms provided performance evaluated efficiency approach illustrated two examples manufacturing engineering
determined whether approved myelofibrosis drug ruxolitinib jakafi inhibitor janus kinases jak jak could repurposed anti cancer agent solid tumors ruxolitinib synergistically interacted dual erbb inhibitors kill breast well lung ovarian brain cancer cells knock jak erbb recapitulated target drug effects combination ruxolitinib erbb inhibitor rapidly inactivated akt mtorc mtorc stat stat activated elf alpha parallel drug combination reduced expression mcl bcl hsp hsp grp increased expression beclin activated forms stat akt mtor prevented drug induced decline bcl mcl hsp hsp levels expression chaperones maintained akt mtor activity presence drugs protected tumor cells drug combination expression dominant negative elf alpha prevented increase beclin expression protected tumor cells drug combination loss mtor activity associated increased atg phosphorylation autophagosome formation autophagosomes initially localized mitochondria subsequently lysosomes knock beclin suppressed drug induced mitophagy activation toxic domain proteins bax bak tumor cell killing knock apoptosis inducing factor aif protected tumor cells drug combination whereas blockade caspase signaling drug combination released aif cytosol increased nuclear aif eifa localization day transient exposure orthotopic tumors ruxolitinib afatinib profoundly reduced mammary tumor growth following days grown tumors exhibited high levels bad phosphorylation activation erk kappa data demonstrate mitophagy essential component ruxolitinib erbb inhibitor lethality drug combination explored phase trial solid tumor patients
work presents experimental theoretical study intended obtain better understanding adhesion niti shape memory alloy wire thermoplastic polyolefin tpo matrix niti wire surfaces subject different surface treatments chemical conversion coating mechanical atomic force microscopy employed examine nanometer micron scale niti wire surface features resulting treatment experimental pull tests performed assess adhesion degree different treatments increased pull force quantified existing theoretical models wire pull based upon strength materials linear elastic fracture mechanics approaches evaluated extension niti tpo single wire composites reviewed results finite element model fem wherein niti tpo matrix interface modeled cohesive model suggest interface behavior strongly depends mode properties rather mode properties pull residual stresses manufacturing process included addition fem model shown properly account energy dissipation debonding front inelastic deformation niti wire pull
remyelination natural repair mechanism demyelinating disorders central nervous system cns multiple sclerosis several animal models used study demyelination remyelination among toxic animal models oral administration toxin cuprizone leads white gray matter demyelination contrast focal demyelination models include stereotactic application toxin lysolecithin ethidium bromide injection procedure generates local disruption blood brain barrier bbb might thus trigger local inflammatory reaction consequently may influence demyelination remyelination order study consequences applied stereotactic injections cuprizone model demyelination remyelination mediated independent procedure immunohistochemistry performed detect presence lymphocytes activated glial cells injection area blood protein stainings used assess integrity bbb myelin staining evaluate demyelination remyelination processes stereotactic injection led local disruption bbb shown local extravasation blood proteins along injection canal lymphocytes could detected tendency higher microgliosis astrocytosis however changes influence demyelination remyelination processes site injection corpus callosum cerebral cortex results suggest local stereotactic injection major impact cns demyelination remyelination
insufficient excessive thyroid hormone levels fetal development cause long term neurological cognitive problems studies animal models perinatal hypo hyperthyroidism suggest problems may consequence formation maladaptive circuitry cerebral cortex persist adulthood used mouse models maternal hypo hyperthyroidism investigate long term effects altering thyroxine levels pregnancy corresponding embryonic days thalamocortical axon dynamics adult offspring perinatal hypothyroidism linked visual processing deficits humans performed chronic two photon imaging axons boutons primary visual cortex found decrease increase maternal serum levels associated atypical steady state dynamics axons boutons adult offspring hypothyroid offspring exhibited axonal branch bouton dynamics indicative abnormal increase connectivity whereas changes hyperthyroid offspring indicative abnormal decrease connectivity collectively data suggest alterations prenatal levels cause long term synaptic instability circuits could impair early stages visual processing
fractional order controllers among emerging solutions increasing closed loop performance robustness however applied mostly stable processes applied unstable systems tuning technique uses well known frequency domain procedures complex genetic algorithms brief proposes special type controller well novel tuning procedure simple involve optimization routines controller parameters may determined directly using overshoot requirements study stability systems tuning procedure given general case class unstable systems pole multiplicity advantage proposed controller consists simplicity tuning approach case study considered brief consists magnetic levitation system experimental results provided show designed controller indeed stabilize magnetic levitation system well provide robustness modeling uncertainties supplementary loading conditions comparison purposes simple pid controller also designed point advantages using proposed controller
introduction aim interest gut brain axis emerging evidence intestinal microbiota influence central nervous system function led hypothesis probiotic supplementation positive effect mood psychological symptoms depression anxiety although several human clinical trials investigated results inconsistent therefore systematic review meta analytic approach chosen examine probiotic consumption effect psychological symptoms methods online databases pubmed scopus cochrane library searched relevant studies july randomized placebo controlled measured preclinical psychological symptoms depression anxiety perceived stress healthy volunteers pre post supplementation probiotic included control differences scales measurement data converted percentage change standardized mean difference probiotic control groups investigated using revman software random effects model used analysis heterogeneity assessed using statistic quality assessment undertaken using rosendal scale results seven studies met inclusion criteria provided data nine comparisons studies passed quality analysis meta analysis showed supplementation probiotics resulted statistically significant improvement psychological symptoms standardized mean difference confidence interval compared placebo conclusion results show probiotic consumption may positive effect psychological symptoms depression anxiety perceived stress healthy human volunteers
zika virus disease caused virus transmitted primarily aedes mosquitoes people zika virus disease symptoms including mild fever skin rash conjunctivitis muscle joint pain malaise headache symptoms normally last days scientific consensus zika virus cause microcephaly guillain barre syndrome association neurological complications also investigated aim present review summarize discuss evidence base data regarding zika virus related complications copyright wolters kluwer health inc rights reserved
remains great challenge biomimetic dolphin robot leap water reason requirements high speed exquisite motion control paper estimate minimum exit speed allows dolphin completely leap water first time build self contained leaping dolphin robot commercially available actuators power supply quantify possible impact body length minimum exit speed leap employ rigid bodymodel rather particle model numerically evaluate leaping process furthermore robotic prototype intended leap motions created particular emphasis streamlining high thrust tail propulsive mechanism designs conjunction passive control strategy dorsoventral propulsion underwater tests untethered dolphin robot demonstrate effectiveness proposed methods mechatronic designs found dolphin robot successfully performed leaps length specific speed body lengths per second emergence angle ranging degrees
pipe faults leakage blockage commonly exist water pipeline systems essential identify fix failures appropriately order reduce risk water pollution enhance security water supply recently transient based detection methods developed advantages non intrusion efficiency economics compared traditional methods however method far limited mainly simple pipelines single known type pipe fault system paper aims extend transient based method multiple fault detection water pipelines purpose study introduced efficient robust method transient pressure signal analysis combination empirical mode decomposition hilbert transform order better identify detect different anomalies leakage blockage junction pipelines validate proposed transient based time frequency analysis method laboratory experimental tests conducted study simple pipeline system multiple unknown types pipe faults including leakages blockages junctions preliminary test results analysis indicate multiple pipe faults simple pipelines efficiently identified accurately located proposed method
paper aid symbolic computation investigate generalized nonlinear schrodinger maxwell bloch equation describes propagation optical soliton inhomogeneous two level dielectric tapered fiber medium virtue darboux transformation method two soliton solutions generated based constructed lax pair figures plotted illustrate properties obtained solutions moreover manipulating dispersion nonlinearity profiles various soliton control systems investigated promising potential applications design soliton compressor soliton amplification highspeed optical devices ultralarge capacity transmission systems means able control soliton types suitably selected values parameters additionally soliton control techniques proposed investigated expect analysis could observed future experiments
order fully understand specific hydrodynamic relationship young wind generated gravity capillary waves longer gravity waves laboratory experiment devised observe changes short wave spectral behavior phase long wave paper endeavors expand body laboratory wave modulation data extend investigation support radar remote sensing ocean surface waves measurements made university miami surge structure atmosphere interaction facility air sea interaction saltwater tank wind wave tank referenced wind speeds ranging paddle generated wave steepnesses varying polarimetric camera used capture high sampling frequency maps wave slope yielding spatiotemporal information short wind wave behavior provided temporal variations wavenumber spectrum approximate sic rad simultaneous colocated long wave phase measured via side looking camera hydrodynamic modulation transfer function mtf phases found general agreement established values radians given wind speeds positive phase modulation places immediately downwind long wave crest mtf magnitudes strongest high wavenumbers lowest wind speeds results also presented show modulation gravity capillary pure capillary waves variations mean square slope long wave phase peak roughness enhancement found move upwind long wave crest increasing wind forcing
nocardia gram positive aerobic pathogen usually affects immunocompromised patients report case pulmonary infection caused rare nocardia species nocardia beijingensis year old woman received alemtuzumab treatment multiple sclerosis invasive pulmonary infection successfully treated meropenem
aim study examined efficacy safety peanut oral immunotherapy oit methods recruited patients aged six years years moderate tosevere reaction double blind placebo controlled peanut challenge received oit eight month build phase maintenance phase controls avoided peanuts measured specific immunoglobulin ige igg peanuts ara monitored adverse events bronchial hyper responsiveness bhr methacholine fractional concentrations exhaled nitric oxide feno median follow period months results oit patients passed build phase tolerated peanuts post treatment challenge controls desensitised risk ratio confidence interval oit ige peanut ara decreased igg increased consuming peanuts harmful effects bhr feno annual incidence rate emergency visits follow period per patient days conclusion peanut oit efficacious severe allergies without negative effects airway inflammation unpredictable long term reactions might occur
word open source everywhere linux technology gnu foundation addition open source software operating systems open source hardware also progressing becoming center point attraction researchers across nook corner world widely adopted open source hardware available right arduino arduino various products like hoards lilypad shields aim research paper explore world arduino technology terms boards lilypad shields covering depth regarding technical specifications features real world applications arduino technology enabled various manufactures research enthusiasts come customized boards shields per research requirements area implementations arduino open source community also providing platform researchers come innovative research applications market ready products terms home automation robotics wireless connectivity drones many others
background sought evaluate interobserver intraobserver reliability radiographs magnetic resonance imaging mri grading osteoarthritis patients scapholunate advanced collapse slac scaphoid nonunion advanced collapse snac determine whether mri likely radiographs detect carpal osteoarthritis methods radiographs studies patients slac snac arthritis reviewed two hand surgeons two radiologists graded according severity osteoarthritis seven carpal joints interobserver intraobserver reliability assessed using weighted kappa analysis odds ratios calculated compare likelihood mri versus radiographs determination moderate severe osteoarthritis results measures reliability higher mri radiographs radiographic assessment patients combined interobserver agreement moderate intraobserver agreement also moderate mri interobserver agreement substantial intraobserver agreement almost perfect joints combined patients slac snac mri times likely demonstrate moderate osteoarthritis compared radiographs patients slac mri times likely radiographs show moderate osteoarthritis radiolunate joint patients snac difference demonstration moderate osteoarthritis mri compared radiographs conclusion carpal osteoarthritis reliably assessed mri radiographs mri sensitive demonstrating moderate changes osteoarthritis radiographs especially radiolunate joint patients slac arthritis implications surgical management slac snac arthritis preoperative planning mri included diagnostic workup evaluation patients slac snac arthritis
nanotechnology transformed materials engineering however despite much excitement scientific community translation nanotechnology based developments suffered significant translational gaps particularly field biomedicine many concepts investigated entered routine clinical application safety concerns associated socioeconomic uncertainties together lack incentives technology transfer undoubtedly imposing significant hurdles effective clinical translation potentially game changing developments commercialisation aspects rarely considered early stages many cases market identified early process hence precluding market oriented development however methodologies depth understanding mechanistic processes existing environmental health safety ehs community could leveraged accelerate translation discuss important stepping stones nano medicine development along number suggestions facilitate future translation
previous studies shown estrogen regulates bone homeostasis regulatory effects oxidative stress however unclear estrogen deficiency triggers reactive oxygen species ros accumulation recent studies provide evidence lymphoma mlv insertion region bmi plays critical role protection oxidative stress gene directly regulated estrogen via estrogen receptor transcriptional level study ovariectomized mice given drinking water without antioxidant acetyl cysteine nac supplementation compared sham mice results showed ovariectomy resulted bone loss increased osteoclast surface increased ros levels cell activation increased tnf rankl levels serum cells nac supplementation largely prevented alterations bmi expression levels dramatically downregulated cells ovariectomized mice supplemented drinking water bmi deficient mice without nac compared wild type mice found bmi deficiency mimicked alterations observed ovariectomy whereas nac supplementation reversed alterations induced bmi deficiency cells critical mediating ovariectomy induced bone loss assessed whether bmi overexpression lymphocytes protect estrogen deficiency induced osteoclastogenesis bone loss inhibiting oxidative stress cell activation rankl production bmi transgenic mice bmi specifically overexpressed lymphocytes ovariectomized compared sham mice found bmi overexpression lymphocytes clearly reversed alterations induced ovariectomy results study indicate estrogen deficiency downregulates bmi subsequently increases ros cell activation rankl production cells thus enhancing osteoclastogenesis accelerating bone loss study clarifies novel mechanism regulating estrogen deficiency induced bone loss american society bone mineral research
power lines communication plc uses existing power lines household wiring communication several functions computer networking utility control systems smart grid areas plc used provide internet services households small businesses often referred broadband power lines general idea plc system modulate radio signal data transmit overhead power lines different band frequencies study electromagnetic compatibility emc aspects operation high frequency electrical network electromagnetic radiation power lines communication plc running unshielded conductors possible effects devices human health paper proposed computation code based schelkunoff formalism calculating high frequency electromagnetic field power transmission lines computation results compared previous results using nec software using formalism antennas
investigated interaction approach behaviours measured performance resource gathering task self reported global life stress predict substance use hypothesis high levels approach behaviour combination high life stress would predict elevated substance use guided reinforcement sensitivity theory gray mcnaughton ninety three young adult students women men completed computerized resource gathering task questionnaires assessing global life stress substance use consistent hypothesis approach behaviour positively related substance use individuals high life stress findings suggest person environment interactions useful understanding substance use discuss approach motivated individuals may arrive different substance use outcomes function stressful contexts copyright john wiley sons ltd
design shopping designers explore design space gain insight trades feasible impractical solutions well learn alternatives optimization selection design space consists multidimensional sets data order select best design among numerous alternatives designers may use several different graphs study test find appropriate graph indicate best solution corresponding set objectives represented design scenario constraint must done shortest possible time three graph types tested three different design scenarios one car chosen total response quality index proposed computes quality designer choice given scenario total tests participants performed parallel coordinates plot proved best graph selection design shopping
objective moderately preterm weeks late preterm weeks infants higher risks mortality growth developmental problems herein present new concept nutritional assessment total energy intake tei sum total kilocalories administered nutrient forms methods fifty two preterm infants classified appropriate gestational age aga small gestational age sga groups received nutrient therapy protocol sum daily energy intake days birth determined results tei kcal days group kcal days aga group kcal days sga group groups tei days significantly correlated body weight gain tei days birth inversely correlated body weight loss rate birth conclusion tei well correlated anthropometric changes birth tei may used effectively assess preterm infants nutritional needs
solve different time delays exist control device installed spatial structures study discrete analysis using precise algorithm selected solve multi time delay issue long span structures based market based control mbc method concept interval mixed energy introduced computational structural mechanics optimal control research areas translates design mbc multi time delay controller solution segment matrix approach transforms serial algorithm time parallel computing space greatly improving solving efficiency numerical stability designed controller able consider issue time delay linear controlling force combination especially effective large time delay conditions numerical example long span structure selected demonstrate effectiveness presented controller time delay found significant impact results
geotextiles made nonwoven fabrics used different fields groynes dams seawalls revetments dunes hillsides structures nonwoven fabrics changed accordingly study explores influence different content kevlar fibers mechanical physical properties kevlar polyester pet complex nonwoven fabrics specified nonwoven fabric manufacturing process kevlar fibers pet fibers blended various ratios form kevlar pet complex nonwoven fabrics tested tear strength air permeability water permeability experiment results show increasing kevlar fibers reduces tear strength air permeability water permeability
firm develop distribute use knowledge effectively efficiently ways increase ability pursue ambidextrous orientation synthesizing insights social cognition upper echelons perspectives offer new theoretical vantage point brings role top management teams cognitive structure fore particular enabling influence transactive memory systems argue transactive memory provides top management team system generating distributing integrating knowledge based members specific areas expertise ways increase ability differentiate integrate strategic agendas ambidexterity multisource study top management teams sample technology based small medium sized firms find top management teams well developed transactive memory systems able pursue ambidextrous orientation impact transactive memory also shaped diverse organizational experience functional expertise within teams discuss scope significance findings theory future research managerial practice
paper new voltage mode first order pass filter presented proposed filter provides non inverting inverting outputs configuration circuit composed single universal voltage conveyor uvc operational transconductance amplifier ota capacitor considering electronically tunability properties ota phase responses proposed active circuit controlled external bias current circuit suitable wideband applications active passive sensitivities low theoretical results verified pspice simulations using bjt implementations uvc ota
one main objectives spanish sleep society promote healthy sleep general population health professionals document aims conduct review current scientific literature sleep habits serve basis establish set general recommendations regarding healthy sleep use general population spain well identify main challenges faced research sleep habits document developed multidisciplinary team made members spanish sleep society experts paediatric sleep medicine clinical neurophysiology pulmonology neurology chronobiology physiology psychology existing scientific literature dealing sleep habits general population reviewed following aspects addressed current state sleep habits spanish population generic review optimum number hours sleep impact environmental setting noise temperature illumination etc hours sleep diet sport together several specific sections children teenagers shift workers drivers different vehicles conclusions aspects addressed document resulted set final general recommendations serve guide general population health professionals likewise principal environmental challenges future lines research also discussed
micrornas mirnas known mediate post transcriptional gene silencing cytoplasm recent evidence indicates may also possess nuclear roles regulating gene expression previous study showed mir involved multidrug resistance leukemia cells regulation drug efflux pump glycoprotein protein encoded human multidrug resistant abcb mdr gene however transcriptional regulatory mechanisms responsible remain elucidated deepen description mechanism transcriptional gene silencing mdr promoter initially performed bioinformatics search potential mir binding sites mdr gene promoter sequence interestingly find mir binding sites region suggesting indirect regulation six representative transcriptional factors involved mdr gene regulation silico analysis revealed kappa specific binding site mir results luciferase reporter assay western blot flow cytometry shown suggest mir might modulate human mdr expression inhibiting kappa indirect mechanism mdr regulation furthermore employing human macrophage like cell line observed comparable results kappa regulation also observed significant reduction tnf alpha mrna well secreted pro inflammatory cytokines following mir expression suggesting canonical kappa target genes might also potential targets mir leukemia cells elsevier inc rights reserved
article deals main features accessibility implemented mobile operating system order become basis subsequent research related subject showing attribute accessibility evaluated systems currently mobile platforms common market order achieve accessibility attributes identified categorized according orientation visual aural locomotion established functionalities implemented analyzed platforms resulted better result android ios finally comparative evaluation showed degree accessibility evaluated operating systems order verify offer higher level accessibility regarding identified features results showed android operating system one implements higher percentage features compared counterparties
coccidia infection rabbits one several species parasites genus eimeria causes coccidiosis disease leading huge economic losses rabbit industry eimeria magna one causal agents rabbit coccidiosis characterized mildly pathogenic moderately immunogenic previous studies study identified chinese isolate magna testing biological features oocyst morphology size prepatent time sequencing internal transcribed spacer dna fragment isolate highly pathogenic infection rabbits oocysts caused reduction weight gain days addition immunization oocysts prevented body weight loss infection oocysts indicating high immunogenicity isolate study described distinctive phenotype chinese isolate magna contributed research geographic variation rabbit coccidia elsevier rights reserved
development smart materials become prominent issue present industries smart material included functions needed microfabrication complex design able become simply reduce weight parts functionalized materials traditional mechanical polishing method even though surface roughness good polishing still remains slight polish mark deformed layer therefore method applicable product requires ultra clean surface quality thus introduced electrochemical polishing method electrochemical elution applied excluding traditional processing method contact tool workpiece always happens study taguchi design method introduced applying taguchi design one significantly reduce time required experimental investigation effective investigating effects multiple factors performance well study influence individual factors determine factor influence less experimental results increases processing time case electrochemical polishing stainless steel plates able confirm improved surface quality start cutting elapsed rapidly improved surface quality showed exceeded one area surface quality degree improvement slowing
purpose study investigate shock attenuation properties long pile synthetic turf investigate properties using modeling simulation method appropriate model based reliable data precise identification method required previous studies unstable data often observed uneven top yarns sprouted infill material therefore properties infill part buried yarns infill materials considered first sprouted yarn causes unstable shock attenuation reason special construction specimens different hardness levels almost sprouted yarn prepared multi intensity multi area impact tests parameter identification performed specimen results show stable data could acquired parameter identification findings indicate applicability modeling simulation method evaluating shock attenuation properties long pile synthetic turf authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
aims data regarding prevalence risk factors poor bone health aging individuals long standing available study aim describe prevalence bone fragility identify factors associated low bone density individuals long term methods examined prevalence non vertebral fractures subjects enrolled joslin year medalist study measured bone mineral density bmd dual energy ray absorptiometry femoral neck lumbar spine radius subset subjects mean age years duration years hbac significant clinical demographic differences rest cohort results medalists low prevalence fractures hip wrist normal score values spine total hip femoral neck radius differences sites significant relationship found lower bmd higher total cholesterol triglycerides ldl levels hbac low bmd femoral neck associated cardiovascular disease adjustment confounding factors prevalence risk ratio cvd diabetic vascular complication found associated low bmd conclusions first data regarding bone health aging individuals diabetes years low rates non vertebral fractures normal score suggest long diabetes duration increase risk bone fractures medalists compared non diabetic peers additionally association cardiovascular disease demonstrates bmd differences groups likely due glycemic control alone
liver transplantation promising widely accepted treatment patients terminal liver disease however transplantation restricted lack suitable donors resulting significant waiting list deaths paper proposes novel donor recipient allocation system uses machine learning predict graft survival transplantation using dataset comprised donor recipient pairs king college hospital united kingdom main novelty system tackles imbalanced nature dataset considering semi supervised learning analysing potential obtaining robust equitable models liver transplantation propose two different sources unsupervised data specific problem recent transplants virtual donor recipient pairs two methods using data model construction semi supervised algorithm label propagation scheme virtual pairs label propagation method shown alleviate imbalanced distribution results experiments show use synthetic real unsupervised information helps improve stabilise performance model leads fairer decisions respect use supervised data moreover best model combined model end stage liver disease score meld moment popular assignation methodology worldwide decision support system considers compatibility donor recipient prediction system recipient severity via meld score supporting principles fairness benefit elsevier rights reserved
improve porosity ceramsite concrete also improve sound absorbing property paper expanded perlite polypropylene fibers foaming agent added improve porosity ceramsite concrete results show three kinds raw materials enhance sound absorbing properties samples relations porosity sound absorption different sound frequencies microstructure analysis established study also found polypropylene fiber improve strength materials contrast expanded perlite foaming agent significantly reduce strength mechanisms analyzed sem photos
confined impinging jets cijs highly efficient mixers scales mixing cijs controlled opposed jets interaction mechanistic model described accurately predicts impinging position opposed jets large range flow rate ratios impinging point position shown impact dynamic properties flow achieved mixing quality opposed jets kinetic energy ratio shown critical impact mixing similar reynolds number mixing chamber design relation proposed verified opposed injectors diameters ratio enables operate cijs optimum mixing conditions large ranges flow rate ratios viscosity density ratios opposed streams optimum values asymptotes large small reynolds number depending process stoichiometry viscosity density ratios opposed jet streams american institute chemical engineers
introduction social structural inequities impede access retention hiv care among structurally vulnerable people living hiv plhiv use drugs resulting disparities hiv related outcomes among plhiv use drugs pose barriers optimization hiv treatment prevention tasp initiatives undertook study examine engagement impacts integrated hiv care services model tailored needs plhiv use drugs vancouver canada setting community wide tasp initiative methods conducted qualitative interviews plhiv use drugs recruited peter centre hiv care facility operating integrated services model harm reduction approach employed novel analytical techniques analyse participants service trajectories within facility understand hiv service environment influences access retention hiv care among structurally vulnerable plhiv use drugs results findings demonstrate participants structural vulnerability shaped engagement hiv care facility provided access resources facilitated retention hiv care antiretroviral treatment adherence additionally integrated service environment helped reduce burdens associated living extreme poverty meeting participants subsistence food shelter needs moreover access multiple supports created structured environment participants could develop routine service use patterns prolonged engagement supportive care services findings demonstrate low barrier service models mitigate social structural barriers hiv care complement tasp initiatives plhiv use drugs conclusions findings highlight critical role integrated service models promoting access health support services structurally vulnerable plhiv complementing structural interventions integrated service models tailored needs structurally vulnerable plhiv use drugs pursuant goals tasp
similarly correspondence radical ideals polynomial ring varieties algebraic geometry correspondence radical differential ideals analytic solution sets established differential algebra tutorial discusses aspects correspondence involving symbolic computation particular introduction thomas decomposition method given splits system polynomially nonlinear partial differential equations finitely many called simple differential systems whose solution sets form partition original solution set power series solutions simple system determined straightforward way conversely certain sets analytic functions admit implicit description terms partial differential equations inequations strategies solving related differential elimination problems applications symbolic solving differential equations presented maple implementation thomas decomposition method freely available
background gene expression profiles intestinal mucosa chickens pigs fed long term periods days weeks diet rich rye diet supplemented zinc respectively chickens one day amoxicillin treatment chickens recorded recently dietary interventions frequently used modulate animal performance therapeutically monogastric livestock study changes gene expression induced three interventions cultured intestinal porcine epithelial cells ipec recorded short term period hours compared vivo gene expression profiles order evaluate capability vitro bioassay predicting vivo responses methods lists response genes analysed bioinformatics programs identify common biological pathways induced vivo well vitro furthermore overlapping genes pathways evaluated possible involvement biological processes induced vivo datamining consulting literature results three interventions limited number identical genes common biological processes pathways found affected respective interventions however several enterocyte specific regulatory secreted effector proteins responded vitro could related processes regulated vivo processes related mineral absorption epithelial cell adherence tight junction formation zinc microtubule cytoskeleton integrity amoxicillin cell cycle progression mucus production rye conclusions short term gene expression responses dietary interventions measured vitro bioassay low predictability long term responses measured intestinal mucosa vivo short term responses set regulatory effector genes measured bioassay however provided additional insight specific processes piglets broilers may modulated early signalling molecules produced enterocytes relevance set regulatory effector genes cognate biological processes zinc deficiency supplementation gluten allergy rye amoxicillin administration humans discussed
analyzed incidence clinical characteristics prognostic factors outcome central nervous system cns infections consecutive patients receiving umbilical cord blood transplantation ucbt hla matched sibling donor stem cell transplantation mst thirty four cns infectioiis documented median time days transplantation range cumulative incidence risk developing cns infection day day years year cns infection ucbt mst causative micro organisms cns infections fungi virus toxoplasma spp bacteria fungal infections occurred patients ucbt mst due aspergillus spp cryptococcus neoformans scedosporium prolificans mucor except patient died cns fungal infection viral infections occurred patients ucbt mst due human herpes virus cytomegalovirus varicella zoster virus cns toxoplasmosis diagnosed patients ucbt mst pathogens staphylococcus spp nocardia spp streptococcus pneumoniae mycobacterium tuberculosis twenty patients died cns infection multivariable analysis ucbt disease stage beyond first complete remission independently associated risk developing cns infections year overall survival patients developed cns conclusion study showed cns infections significant clinical problem stem cell transplantation associated poor survival frequent ucbt compared mst american society blood marrow transplantation
study utilizes geospatial tools remote sensing geographical information systems gis global positioning system gps examine land loss land cover change landuse kutubdia island bangladesh multi spectral scanner mss thematic mapper landsat oli imageries used land cover change assessing landuse patterns spatial video data collected using contour gps camera using remote sensing analysis three different land cover classes water trees forest agriculture identified land cover changes detected results show estimated land lost significant changes taken place estimated area accretion taken place study period using gis eight different landuse patterns identified based spatial video data
background nursing notoriously high stress occupation emotionally taxing physically draining high incidence burnout addition damaging effects stress nurses health well stress also major contributor attrition widespread shortages nursing profession although exist promising person interventions addressing problem stress among nurses experience group across multiple projects hospitals indicated schedules workloads nurses pose problems implementing person interventions web based interventions might ideally suited addressing high levels stress among nurses purpose purpose study evaluate effectiveness web based breathe stress management nurses program methods randomized controlled trial conducted nurses five hospitals virginia one hospital new york primary outcome measure perceived nursing related stress secondary measures included symptoms distress coping work limitations job satisfaction use substances relieve stress alcohol consumption understanding depression anxiety results program group participants experienced significantly greater reductions control group full nursing stress scale six seven subscales significant results found moderator analysis found nurses greater experience benefitted conclusion using web based program holds tremendous promise providing nurses tools need address nursing related stress elsevier inc rights reserved
cellular automata artificial neural networks anns used researchers last three decades simulate land use change luc conventional ann models assign cell one land use class reality cell may belong several land use classes simultaneously recently developed multi label concept overcomes limitation land change science although concept new paradigm nonexclusive classes shown considerable merit several applications studies land change science applied addition determining transition rules conventional difficult number drivers large since shown potential model consider neighborhood effects ann shown effective determining transition rules integrated ann model overcome limitations tool study specifically extended ann based land transformation model ltm based model concept create integrated ltm modeling framework also compared using standard evaluation measures differences proposed integrated model conventional based ltm model called ltm parameterization made using learning testing procedure common machine learning results showed modified luc model ltm produced consistently better goodness fit calibration values compared ltm outcome modified model used managers decision makers improved urban planning
background diet affect kidney health effects inflammation objective tested whether adapted dietary inflammatory index adii associated kidney function whether effects diet chronic low grade inflammation explain association methods observational analysis elderly community dwelling participants aged independent cohorts uppsala longitudinal study adult men men prospective investigation vasculature uppsala seniors men women adii calculated food records combining putatively proinflammatory anti inflammatory effects nutrients vitamins trace elements adii validated serum reactive protein crp concentrations estimated glomerular filtration rate egfr assessed serum cystatin cys creatinine crea associations adii egfr investigated crp considered mediator results adjusted analysis higher adii associated higher crp beta lower egfr chronic kidney disease epidemiology collaboration ckd epi cys ckd epi cys crea crp also inversely associated egfr mediation analyses showed total effect adii kidney function ckd epicys crea ckd epicys equations respectively explained mediated serum crp findings similar cohort analyzed separately conclusions proinflammatory diet associated systemic inflammation well reduced kidney function combined analysis community based cohorts elderly individuals results also suggest systemic inflammation one potential pathway dietary pattern linked kidney function
investigation paper dimensional nonlinear evolution equation generated via jaulent miodek hierarchy nonlinear water waves aid binary bell polynomials symbolic computation bilinear forms backlund transformations derived soliton solutions obtained hirota method soliton propagation discussed analytically bell shaped soliton anti bell shaped soliton shock wave seen parameters selected soliton interactions analyzed graphically four kinds elastic interactions presented two parallel bell shaped solitons two parallel anti bell shaped solitons three parallel bell shaped solitons three parallel anti bell shaped solitons see solitons maintain original amplitudes widths directions except phase shifts interaction smaller soliton amplitude faster soliton travels
waste recycling become global environmental health issue pernicious chemicals escape environment due informal nonstandard waste recycling activities involving manual dismantling open burning recover heavy metals open dumping residual fractions heavy metals derived electronic waste waste lead cadmium chromium manganese nickel mercury arsenic copper zinc aluminum cobalt differ chemical composition reaction properties distribution metabolism excretion biological transmission previous studies showed heavy metal exposure adverse effects children health including lower birth weight lower anogenital distance lower apgar scores lower current weight lower lung function lower hepatitis surface antibody levels higher prevalence attention deficit hyperactivity disorder higher dna chromosome damage heavy metals influence number diverse systems organs resulting acute chronic effects children health ranging minor upper respiratory irritation chronic respiratory cardiovascular nervous urinary reproductive disease well aggravation pre existing symptoms disease effects heavy metals children health briefly discussed elsevier ltd rights reserved
paper stand alone photovoltaic sapv power supply system microner sprayer identified proposed designed system composed three main parts sprayer solar power supply control system initially control board data acquisition system designed simulated proteus software implemented using avr microcontroller tested via labview laboratory next prototype system fabricated evaluation purposes panel size positioned horizontally operator head generates day used solar energy source small battery installed system stabiliser sprayer work seven nine hours daily calculated average loss collected energy due non application maximum power point tracker approximately
cloud computing new paradigm distributed computing gained wide popularity relatively short span time increase number functionality features cloud services mind boggling cloud users find trustworthy provider cloud users need confidence cloud providers migrate critical data cloud computing must means determine reliability service providers users choose services assurance provider act malignantly effort made paper formulate hybrid model calculate trustworthiness service providers cloud services evaluated trust value calculated based compliance reputation service logs based compliance reflects dynamic trust reputation computed collective user feedback feedback rating view user invoked services discovered services fulfill user requirements ranked based trust values top cloud services recommended user proposed approach efficient considerably improves service selection process cloud applications
forward backward reflection transmission scattering parameters metamaterial structure anisotropic slabs cascade analyzed signal flow graph technique applied analysis cascaded connection two three anisotropic slabs different orientations also investigated effects geometrical parameters fabrication tolerances individual cells forward backward reflection transmission parameters cascade connection cells note analysis following important points first forward backward reflection parameters become equal one another structure composed even number anisotropic slabs individually characterized non identical forward backward reflection parameters proper orientations exists symmetry structure propagation direction second noted possible obtain identical forward backward reflection parameters structure composed odd number anisotropic slabs finally reflection asymmetry anisotropy cascade connection cells generally enhanced change geometrical parameters individual cells elsevier rights reserved
civic boosters advocate physical arts development path urban revitalization current research examines specialized bricks mortar efforts snapshot outcome evaluations broad policy analyses critiques predatory activity project development overlooked whether efforts mirror general urban development patterns behavior case study explores successful dual nonprofit partnership seattle art museum trust public land build olympic sculpture park recent history explains institutional motivations political strategies identifies organizational assets employed overcome intense market pressures past failures adds richness conventional development wisdom intense focus public private partnerships prevalent model urban development alignment local arts institution national conservation organization may unveil alternative model shed light less visible structure developing urban civic amenities study reinforces connection contemporary urban improvement early beautification agendas via municipal art open space civic leadership
study presents innovative field experiment exploring ethnic discrimination contacts local public officials members swedish society using correspondence study design fictitious individuals arabic swedish sounding names contacted swedish municipalities via email asking questions access preschools findings indicate disadvantageous treatment individuals arabic sounding names terms informal tone replies swedish sounding names replied friendlier welcoming way regarding formal aspects emails whether replied questions posed directly answered statistically significant signs discrimination emerge although differences substantial size disadvantage arabic sounding names still informal disadvantageous treatment sufficient cause concern noteworthy case sweden considering reputation egalitarian immigration friendly democratically well functioning
human brain extraordinarily complex yet origin simple tubular structure development fetal period characterized series accurately organized events underlie mechanisms dramatic structural changes fetal development revealing detailed anatomy different stages human fetal brain development provides insight understanding highly ordered process also neurobiological foundations cognitive brain disorders mental retardation autism schizophrenia bipolar language impairment diffusion tensor imaging dti histology complementary tools capable delineating fetal brain structures macroscopic microscopic levels review structural development fetal brains characterized dti histology major components fetal brain including cortical plate fetal white matter cerebral wall layer ventricle subplate delineated dti histology anisotropic metrics derived dti used quantify microstructural changes dynamic process human fetal cortical development prenatal development animal models fetal white matter pathways traced dti based tractography reveal growth patterns individual white matter tracts corticocortical connectivity detailed anatomical accounts structural changes fetal period may provide clues detecting developmental cognitive brain disorders early stages anatomical information dti histology may also provide reference standards diagnostic radiology premature newborns isdn published elsevier ltd rights reserved
tabulation method usually adopted describe mapping relation analytic function local rules cellular automaton although tabulation method quite suitable describe mapping relation among discrete variables numerous else sentences state decision independent variables computer programming paper define analytic function local rules elementary cellular automaton constructing recognition function states cell neighbors therefore huge number calculations else sentences transferred function calculation due adoption function local rules evolution eca finally simulation results show programming structure optimized programming efficiency enhanced addition proposed method also extended state cellular automata elsevier inc rights reserved
paper presents application clonal algorithm technique detection voltage sags swells meters order monitor short circuit conditions occurring electrical network considered possible conditions symmetry conditions make problem even complicated proposed method steps described construction antibodies cloning mutation clones maturation selection novel antibodies algorithm starts large number monitors decrease number find configuration minimum number monitors ensure monitoring short circuit conditions evaluation methodology performance buses network presented
sets consists internal set bar outer pset bar dynamic characteristics result internal dynamic characteristics bar outer dynamic characteristics bar order extend application sets paper proposes bar recursive binary tree applying dynamic characteristics set bar meanwhile paper provides structures characteristics bar recursive binary tree including properties theorems bar recursive binary tree paper also gives method constructing bar recursive binary tree bar recursive binary tree inward contraction characteristics recursive characteristics used many research fields information science technology artificial intelligence knowledge discovery well control theory control engineering
annonaceous acetogenins aags neurotoxins possibly responsible atypical parkinsonism dementia clusters via consumption edible annonaceae fruits presence investigated fruit pulps annona squamosa different locations qualitative analysis aags performed report identification squamocin batches asia caribbean basin indian ocean molecule quantified hplc evidencing content fruit hplc esi tof allowed detection different raw formulas matching aags methodological development performed using representative standards main aags could annotated including bullatacin rolliniastatin annonacin study evidences remarkable homogeneity main aags within species discrepancies minor compounds findings indicate squamosa considered risk factor neurodegenerative disorders elsevier ltd rights reserved
groundwater vulnerability assessment delineating areas susceptible contamination future scenarios aroused worldwide attention study authors estimate future groundwater vulnerability hunan province china urban related land use change climate change scenarios analyze importance related parameters future groundwater vulnerability drastic model including seven parameters depth water table net recharge aquifer type soil type topography impact vadose zone conductivity together extra parameter land use patterns used generate map groundwater vulnerability future scenarios results indicated vulnerability classes increasing trend low high vulnerability future scenarios hunan province may face high groundwater pollution risk future sensitivity analysis indicated depth water table may dominant factor land use pattern sensitive parameter predicted future groundwater vulnerability hunan province decision makers identify potential future groundwater vulnerability take early steps protect groundwater resources
paper engineering method power flow assessment position controlled servomechanism outlined considered system composed permanent magnet synchronous motor coupled standard power converter directly connected slider crank mechanism accurate description consistent power flow model sequential identification technique discussed allows determine dynamic parameters linkage electric motor electronic driver means non invasive experimental measures proposed model allows accurately predict major sources power loss within system elsevier ltd rights reserved
understanding building occupancy critical wide array applications including natural hazards loss analysis green building technologies population distribution modeling due expense directly monitoring buildings scientists rely addition wide disparate array ancillary open source information including subject matter expertise survey data remote sensing information data fused using data harmonization methods refer loose collection formal informal techniques fusing data together create viable content building occupancy estimation paper add current state art introducing population data tables pdt bayesian model informatics system systematically arranging data harmonization techniques consistent transparent knowledge learning framework retains final estimation uncertainty emerging data expert judgment model parameterization pdt aims estimate ambient occupancy units people number building types national sub national level goal providing global coverage present pdt model situate work within larger community report progress multi year project
wound repair surgeries common childhood surgery countries medical treatment impact children mental health authors objective study impact parental presence preschool children reveal conditions precautions parental presence facial trauma surgeries analyzed group preschool children april april parents attended experiment contrasting group preschool children without parental presence means clinical observation questionnaire wound infection rate surgery satisfaction children parents anxiety level studied authors found parental presence would increase infection rate parental presence could reduce children parents anxiety level increase surgery satisfaction rate parental presence lot positive significances children emergency surgery children health care parents anxiety
background per data million unsafe abortions occurred globally women died abortion related complications contributing global maternal mortality emergency contraceptive used intercourse prevent pregnancy case unprotected intercourse contraceptive failure sexual assault considerable proportion abortions prevented timely use emergency contraception objectives study knowledge emergency contraceptives among women reproductive age group methods government hospital based prospective study done period months study included women reproductive age group years years attending opd obstetrics gynaecology department igmc pondicherry predesigned questionnaire provided women asking awareness regarding emergency contraceptives results majority years age urban background educated used regular method contraception time life awareness level emergency contraceptives found ever used emergency contraceptives conclusion emergency contraceptives effective means preventing unwanted pregnancies unfortunately majority women lack awareness emergency methods efforts focused providing health education regarding among females media health professionals
purpose macular optical coherence tomography oct analysis used quantitative measures optic nerve atrophy location far optic nerve head recently led finding microcystic macular edema mme vacuolar inclusions macular inner nuclear layer glaucoma patients involvement individual retinal layers yet unclear glaucoma study systematically investigated glaucoma induced changes macular layers evaluate whether glaucoma associated damage extends beyond macular ganglion cell layer patients methods included consecutive patients eyes confirmed primary open angle glaucoma pseudoexfoliation glaucoma macular oct cross sectional observational study eyes screened presence mme thickness individual retinal layers determined using semiautomatic segmentation algorithm peripapillary nerve fiber layer thickness mean defect visual field testing extracted oct medical records respectively results compared small group eyes apparent glaucoma results found mme eyes primary open angle glaucoma patients eyes pseudoexfoliation glaucoma patients mme confined inner nuclear layer perifoveal ring associated thinning ganglion cell layer thickening macular inner nuclear layer glaucoma eyes without mme showed significant inverse correlation inner nuclear layer thickness glaucoma severity conclusions glaucomatous damage leads gradual thickening inner nuclear layer leads mme severe glaucoma cases changes along nerve fiber loss ganglion cell loss may summarized glaucoma associated retrograde maculopathy
hereditary angioedema hae rare autosomal dominantly inherited disease characterized recurrent self limiting episodes acute tissue swelling management hae past often limited symptom alleviation means painkillers administration fresh frozen plasma situation changed radically implementation new disease specific therapies whose efficacy confirmed clinical trials targeted therapies include recombinant human plasma inhibitor well kallikrein kinin system modulators namely ecallantide icatibant latter latest therapeutic option available hae patients poland disrupts bradykinin pathway blocking receptors aim review update practicing allergologists health care providers new advances treatment acute attacks hae
systolic implementation multiplication usually efficient area time complexity latency usually large thus two low latency systolic multipliers based general irreducible polynomials irreducible pentanomials presented first signal flow graph sfg used represent algorithm multiplication two low latency systolic structures multiplications based general irreducible polynomials pentanomials presented sfg suitable cut set retiming respectively analysis indicates proposed two low latency designs involve least one third less area delay product compared existing designs authors knowledge time complexity structures lowest found literature systolic multipliers based general irreducible polynomials pentanomials proposed low latency designs regular modular therefore suitable many time critical applications
although authentic dialogue teachers young children vital learning process increasingly diverse student populations focus high stakes testing challenge teachers approaches conversations study examined verbal nonverbal interactions five teachers young children using child taken photographs promote conversation analysis exposed teachers nonverbal verbal responsiveness opened closed conversational spaces children describe home contexts teacher child dance illuminates necessary effective pursuit attending verbal nonverbal communication authentic dialogue suggests teacher choreograph attended positioned effective efficient use within increasingly diverse time pressured classroom
background bladder disorders associated interstitial cystitis frequently characterized increased contractility pain purposes study examine effects blocking mammalian target rapamycin mtor exaggerated bladder activity pain evoked cystitis underlying mechanisms responsible role mtor regulating cystic sensory activity results expression mtor mtor mediated phosphorylation ribosomal protein kinase binding protein well phosphatidylinositide kinase pik pathway amplified cyclophosphamide rats compared control rats blocking mtor intrathecal infusion rapamycin attenuated bladder hyperactivity pain addition blocking pik signal pathway attenuated activities mtor accompanied decreasing bladder hyperactivity pain inhibition either mtor pik blunted enhanced spinal substance calcitonin gene related peptide cyclophosphamide rats conclusions data first time revealed specific signaling pathways leading cyclophosphamide induced bladder hyperactivity pain including activation mtor pik inhibition pathways alleviates cystic pain targeting one signaling molecules may present new opportunities treatment management overactive bladder pain often observed cystitis
introduction grandparents often highly involved secondary caregivers grandchildren may influence children psychological physical health outcomes purpose current review gather synthesize research findings effects grandparent involvement children physical health outcomes method pubmed psycinfo medline searched independent reviewers articles reported grandparent involvement children health twenty six articles included final review based selection criteria results relatively studies examined effects grandparent involvement children health outcomes therefore degree influence remains unclear four categories children health outcomes disease illness weight eating behaviors injury safety emerged review results indicated majority studies available reported negative effect grandparent involvement child weight status however important note studies effects grandparent involvement primary outcome amount time grandparents spent grandchildren accounted many studies review qualitative studies limiting types analyses could conducted addition longitudinal studies conducted area discussion based review clear grandparents involved caretaking children across many cultures understand role children health outcomes systematic longitudinal research needs conducted
cryogenics branches physics engineering involve study low temperatures produce materials behave temperatures subject within building services specialization harder understood students requires knowledge many fields chemistry physics refrigeration heat transfer thermodynamics mechanics strength materials etc studies points interactive teaching methods create deeper learning students develop better thinking skills presenting concrete examples students demonstrate better memory appreciated ensure next generations well trained workforce capable tackling complex challenges face days improving access information key component order effectively compete global labor market research proves learning result exercise actually seeing learned leads students process information give meaning time found teaching blackboard chalk implement written course minimum mandatory sufficient proven many today courses made using digital presentations paper presents new method teaching learning cryogenics students enrolled building services specialization faculty civil engineering part transylvania university brasov
paper introduces behavioral model advanced type current conveyor extended controllable inter terminal features type active device offers three independent current input terminals adjustable input resistance currents terminals weighted independent branches electronically adjustable current gains summed output node voltage inter terminal relations advanced controllable voltage difference two pairs input voltages advanced active device offers interesting features future applications analog signal processing functionality model verified pspice simulations
paper quarter car model root mean square response variables calculated roads classified international standard organization based straight line spectrum models covariance expressions derived vehicle response variables assuming road spectrum motor industry research association mira spectrum compared existing results literature international standard mira spectra compared models delivered high resolution frequency domain subspace identification algorithms iri statistic quarter car response calculated road models built curve fitting identification methods measured road spectrum assuming road excitation zero mean gaussian process
gender sexual orientation expressed heterosexual lesbian gay bisexual transgender queer interests behavior compared heterosexual persons lgbtq persons seem experience antisocial behavior including negative discrimination violence assess differences lgbtq related discrimination schools question research degrees violence experienced feeling unsafe lgbtq students staff school differ non lgbtq students staff school secondary analysis carried data dutch national digital monitor survey safety secondary schools participation amounted schools teaching support staff students four indicators constructed school level two mokken scale means assessing severity violence experienced two alpha scale means assessing feeling unsafe analysis mean differences showed lgb students experienced violence felt less safe non lgb students lgb staff felt less safe school non lgb staff lgb students experienced violence school non lgb students lgb students also felt less safe non lgb students years relationships existed lgb staff lgb staff lgb students significant relationships found four lgb school indicators contextual school variables outcomes uniqueness study discussed recommendations made improve assessment promote prosocial behavior students staff schools
article deals information system structural monitoring enables storing analysing presenting short long term monitoring data short term monitoring data meant data acquired single shot measurements load testing structures long term monitoring meant data acquired longstanding observation structures operational conditions conception monitoring information system come already developed systems barab used tunnelling practice argus used monitoring large projects central london data structures monitoring system built typified pilot projects long term monitoring bridges several types short term monitoring load testing bridges monitoring standard structures well monitoring special structures nuclear power station flexible data structures allow integrating data various measuring systems electronic levelling systems robotic total stations gnss systems accelerometers strain gauges metrological sensors different types documents photos technical drawings project documentation events processed data analysis using sql provided different types charts numerical outputs available outputs assigned drawings photos accessible via web based interface system makes possible export data various data formats web based administration also allows setting different user levels particular user access particular project results monitoring information system generally used types structures
history government action hiv aids much teach dynamics possibilities public health policy insufficiently studied social scientists epidemic article draws large set original interviews policy makers thousands news articles extensive documentation reconstruct history three areas debate decision making hiv prevention since needle exchange hiv testing sex education risk groups histories illuminate three key lessons first scientific evidence less power drive public health policy united states united kingdom used comparison case contextualize choices within broader range options second moral concerns weigh heavily united states publicly articulated moral argument countermand dictates solid scientific evidence voices experts practical considerations push public health policy entirely oppositional directions third ear presidential administration usually necessary although always sufficient condition success advocates trying move policy public health indicated direction
paper thermally actuated medical stent staple using shape memory alloy sma designed numerically analysed compared similarly designed stents staples made stainless steel alloy numerical analysis carried using finite element method consistent model used investigate effect materials performance stent staple study takes account interaction stent staple vivo environment modelling vivo environment forces results good agreement reported literature according results concluded three commercially available materials undergo external force sma yields much better results terms maximum displacement amount stress especially undergoing large loads sma produces considerably displacement stainless steel suggests using sma promising path make biomedical stents staples
sparsity phenomena learning processes extensively studied since detection allows derive suited regularized optimization algorithms capable improving overall learning performance paper investigate sparsity behavior may occur nonlinear adaptive filtering problems leverage develop enhanced algorithms particular focus particular class linear parameters nonlinear adaptive filters whose nonlinear transformation based functional link expansion analysis sparsity functional links leads derive family adaptive combined filtering architectures capable exploiting sparseness degree nonlinear filtering propose two different filtering schemes based new block based combined approach well suited sparse adaptive algorithms moreover hierarchical architecture also proposed generalizes different combined schemes need priori information nature nonlinearity modeled experimental results prove effectiveness proposed combined architectures exploiting sparseness degree improving modeling performance nonlinear system identification problems
contact sports athletes often suffer various skin disorders inflammatory diseases bacterial fungal origin atopic dermatitis psoriasis etc resulting long breaks training ruin athletic performance wrestling implies intense skin skin contact creates perfect conditions transmission infectious agents following standard rules hygiene showering handwashing directly competition training exclude possibility get infection sparring partner characterize skin microbial composition wrestlers current manifestation skin disorders metagenomic analysis performed absolute predominance bacillus genus metagenomic profiles wrestlers skin observed contrast existing literature data classic microbiological approaches allowed detect hemolytic forms microorganisms wrestlers skin appeared colonized hemolytic bacilli whereas non wrestler athletes bacteria skin dysbiotic shifts microbial community may cause emergence skin diseases revealed properties could help design highly effective antiseptics contact sports hygiene
restorative justice therapeutic jurisprudence measures recently introduced youth justice systems gatekeepers measures children court magistrates play crucial role success however little research undertaken magistrates views measures article addresses gap presenting results interviews undertaken children court magistrates new south wales australia research suggests magistrates enthusiastic philosophy restorative therapeutic measures reluctant embrace consider resourced poorly understood poorly implemented implications findings discussed
one important parts developing kind software check sustainability software done software testing software engineers varied number test cases taken account test done using unified modelling language uml using combination hybrid revised genetic algorithm along bee colony optimization test come favour finding maximum minimum coverage novel approach tested application smart card users security token user order increase security smart card security token novel approach smart card security token proposed decision making structure self organising systems based software engineering secured details obtained total number smart card users approach total flaws present system easily detected along maximum possible paths novel technique software testing guarantees minimum time considered maximum coverage elsevier ltd rights reserved
exposure media violence related anxiety youth causality effect established experimental study examined effects media violence anxiety blood pressure heart rate late adolescents also examined whether responses varied previous exposure media real life violence college students age female caucasian african american asian hispanic racial minorities randomized view either violent nonviolent high action movie clips participants reported anxiety watching clips well previous exposure violence measures blood pressure heart rate taken baseline movie viewing participants watching violent movie clips showed greater anxiety increase watching nonviolent clips groups experienced increased blood pressure reduced heart rate movie watching compared baseline prior exposure media violence associated diminished heart rate response additionally students previously exposed high levels real life violence showed lower blood pressure increases watching violent clips compared nonviolent clips thus relatively brief exposure violent movie clips increased anxiety among late adolescents prior exposure media real life violence associated lower physiological reactivity high action violent movies respectively possibly indicating desensitization future studies investigate long term anxiety physiological consequences regular exposure media violence adolescence
arrival information age gradually expanded practical application computer networks provided convenience people lives promoted rapid development chinese information industry situation process using computer network gradually produced network security problems affected security user personal information affected various illegal attacks bury large security risks popularization use computer network indirectly reduce efficiency variety information security transmission restrict future level network services order change current situation development adverse need pay attention rational use network security technology structure reliability computer network defense mechanism enhance safety performance network maximize meet actual needs users based paper carry systematic elaboration security technology computer network
background postural instability one disabling motor symptoms parkinson disease indices multi muscle synergies new measurements postural stability objectives explored effects dopamine replacement drugs multi muscle synergies stabilizing center pressure coordinate adjustments prior self triggered perturbation patients parkinson disease hypothesized synergy indices synergy adjustments would improved dopaminergic drugs methods patients hoehn yahr stages iii performed whole body tasks drugs standing muscle modes identified factors muscle activation space synergy indices stabilizing center pressure anterior posterior direction quantified muscle mode space load release task results dopamine replacement drugs led consistent organization muscles stable groups muscle modes drugs patients showed larger indices synergies anticipatory synergy adjustments contrast medication effects seen anticipatory postural adjustments performance indices conclusions dopamine replacement drugs lead significant changes characteristics multi muscle synergies parkinson disease studies synergies may provide biomarker sensitive problems postural stability agility efficacy dopamine replacement therapy elsevier ltd rights reserved
combining biological components cells tissues soft robotics enable fabrication biological machines ability sense process signals produce force intuitive demonstration biological machine one produce motion response controllable external signaling whereas cardiac cell driven biological actuators demonstrated requirements machines respond stimuli exhibit controlled movement merit use skeletal muscle primary generator actuation animals contractile power source report development printed hydrogel bio bots asymmetric physical design powered actuation engineered mammalian skeletal muscle strip result net locomotion bio bot geometric design material properties hydrogel bio bots optimized using stereolithographic printing effect collagen fibrin extracellular matrix proteins insulin like growth factor force production engineered skeletal muscle characterized electrical stimulation triggered contraction cells muscle strip net locomotion bio bot maximum velocity similar body lengths per min modeling simulation used understand effect different design parameters bio bot mechanism motion demonstration advances goal realizing forward engineered integrated cellular machines systems myriad array applications drug screening programmable tissue engineering drug delivery biomimetic machine design
egfr mutated nsclc genetically heterogeneous disease includes distinct mutations implications mutational subtype prognostic predictive value increasingly understood although common egfr mutations exon deletions mutations predict sensitivity egfr tyrosine kinase inhibitors tkis recognized outcomes may improved patients exon deletions additionally patients uncommon egfr mutation response egfr tki therapy highly variable depending mutation given growing recognition genetic clinical variation seen disease development comprehensive bioinformatics driven tools analyze response uncommon mutation subtypes inform clinical decision making increasingly important clinical trials novel egfr tkis prospectively account presence uncommon mutation subtypes study design international association study lung cancer published elsevier inc rights reserved
article aims analyze whether change characteristics ufscar cooperation company using object analysis projects established university external partners last five years managed institutional support scientific technological development foundation fai among results emphasized ufscar cooperation projects environment characterized cases low long intervals regarding type financing private companies main activities developed university study activities consulting advisory research development projects another important factor partnerships private companies occurred center exact sciences technology ccet departments civil engineering materials engineering number projects volume resources furthermore possible note growth potential cooperative activity ufscar company
histihd gene encodes histone involved gene silencing heterochromatin formation histhd expression upregulated primary gastric cancer tissue study explored effects histhd expression lung cancer mechanisms histhd expression measured immunohistochemistry pcr lung cancer tissues human lung cancer cell lines cell proliferation assessed mtt assay flow cytometric analysis used determine cell cycle distribution apoptosis levels related proteins detected western blotting bioinformatics analysis performed investigate related signaling pathways cdna microarray analysis performed identify differentially expressed genes following histhd knockdown histhd expression upregulated lung cancer tissue samples human lung cancer cell line regulation histhd expression nucleus cells lung cancer tissues significant associated tumor stage lymph node metastases downregulation histhd expression led suppression proliferation colony forming ability cell cycle arrest phase promotion cell apoptosis microarray data revealed genes differentially expressed histhd knockdown cells genes shown linked numerous pathways including cell cycle signaling mcm western blot analysis confirmed upregulated expression thbs tpi genes downregulated expression cdk cdkn ccne genes conclusion results suggest histhd highly expressed lung cancer cell lines tissues furthermore histhd may important cell proliferation apoptosis cell cycle progression implicated potential therapeutic target lung cancer
paper describes imathome ios application smart home configuration management application built framework homekit made available ios communicating controlling home automation accessories attention put design interaction application order make interaction style much coherent possible ios apps supporting users without programming skills unwittingly create event condition action rules similar systems usually defined constructs results user test demonstrate imathome easy use well accepted end users different age background
term somatization refers manifestation multiple somatic complaints explained organic changes according literature percent medical visits related somatization medical training put enough emphasis evaluation possible psychological background certain somatic symptoms physicians may feel powerless make unjustified diagnostic therapeutic efforts patients may also feel helpless frustrated anxiety intensity complaints may increase stress important factor somatization process stress reduction improvement coping key elements treatment guidelines chronic diseases evidence based interventions range short counselling medication cognitive behavioral psychotherapy reattribution short minutes structured intervention implemented primary secondary care certain cases result significant decrease somatic symptoms anxiety
study author investigates practical limitation recently proposed embedded cryptographic signature authentication scheme physical layer employing log likelihood ratio tag bit approximation author shows equivalent authentication channel observed secondary receiver viewed binary input additive white gaussian noise channel sphere packing lower bound employed show transmission capability practical finite length authentication tags achieve effective coverage area primary secondary receivers essentially requires efficient low rate channel coding schemes near sphere packing bound performance secondary receiver contrasts sharply pessimistic conclusion jiang
evaluate whether reactive protein crp including variation within normal range predictive long term disease outcome juvenile idiopathic arthritis jia consecutive patients newly diagnosed jia included prospectively defined geographic areas nordic countries inclusion criteria availability baseline serum sample within months disease onset year clinical assessment data systemic onset jia included crp measured high sensitive elisa detection limit one hundred thirty participants median follow time months range included follow patients remission medication absence remission associated elevated level crp baseline odds ratio confidence interval applying cutoff normal upper limit risk achieving remission increased variations crp within normal range predictive impact disease activity follow baseline levels esr available patients elevated esr associated absence remission multivariable logistic regression analysis results study indicate baseline crp concentrations predictive poor outcome year follow could demonstrate predictive value crp variations within normal range
solute transport extracellular matrix ecm crucial chondrocyte metabolism cartilage injury affects solute transport cartilage due alterations ecm structure solute matrix interactions therefore cartilage injury may detected using contrast agent based clinical imaging present study effects mechanical injury transport negatively charged contrast agents cartilage characterized using cartilage plugs injured mechanical compression protocol effective partition coefficients diffusion fluxes iodine gadolinium based contrast agents measured using high resolution microct imaging contrast agents studied effective diffusion fluxes increased significantly particularly early times diffusion process increase min iodine dtpa increase min diatrizoate effective partition coefficients unaffected mechanically injured cartilage mechanical injury reduced content collagen integrity cartilage superficial zone study suggests alterations contrast agent diffusion flux non equilibrium transport parameter provides sensitive indicator assessment cartilage matrix integrity partition coefficient equilibrium distribution solute findings may help developing clinical methods contrast agent based imaging detect cartilage injury
considerable work carried risk qualitative quantitative assessment far less risk identification paper introduces newly developed method risk identification based micro risk breakdown structure newly introduced identification procedure called preventive root cause effective remedial also introduces risk responsibility matrix distributes responsibilities associated risk among project stakeholders introduces newly developed method qualitative quantitative assessment item using fuzzy set fuzzy probability theories output proposed assessment method pre mitigation contingency risk represents quantitative indicator decision making whether mitigate risk considered two case studies one numerical example presented demonstrate applicability illustrate essential features proposed identification allocation assessment methods
data warehouses designed multidimensional structure based fact dimension tables oriented towards indicator systems inform decision making frequent loads associated kind system performed fact table assuming dimensions common time independent lead serious consequences terms integrity completeness obtained information number proposals made update dimension table calling process slowly changing dimensions scd focused relational data design article focuses proposing strategies improve response time queries associated data warehouse design dimension tables change comparing scd designs relational object relational databases finally case presented allows compare performance designs
starting classical differential cryptography describe construct particular parameters elliptic curves application domain information security results conclude key used symmetrical encryption article review solution parties authenticated based secret knowledge random parameter
rich literature nature mental health related stigma processes severely affects life chances people mental health problems however applying knowledge deliver evaluate interventions reduce discrimination stigma lasting way complex long term challenge conducted narrative synthesis systematic reviews published since supplemented papers published subsequently examples recent work evidence small moderate positive impacts mass media campaigns interventions target groups terms stigma related knowledge attitudes intended behaviour terms desire contact however limited evidence longer follow times suggests clear whether short term contact interventions lasting impact risk short term interventions may short term impact suggests need study longer term interventions use interim process outcome data improve interventions along way scope thorough application intergroup contact theory whenever contact used evidence based teaching assessment methods skills training used target groups
review paper milestones challenges achieved experienced african environmental scientists regarding assessment water pollution caused presence pharmaceutical compounds water bodies highlighted identification quantification pharmaceuticals african water bodies important general public large due lack information consumption pharmaceuticals promote human health usually followed excretion drugs via urine fecal matter due slight transformation human metabolism therefore large amounts pharmaceuticals discharged continuously wastewater treatment plants african rivers due inefficiency employed sewage treatment processes large portions african communities even proper sanitation systems results direct contamination water resources human waste contains pharmaceutical constituents among pollutants therefore article provides overview recent studies published mostly focused occurrence different classes pharmaceuticals african aqueous systems also current analytical methods used africa pharmaceutical quantification environmental waters highlighted african scientists started investigate material remediation processes elimination pharmaceuticals water elsevier ltd rights reserved
manycore processors way face always growing demand digital data processing however putting closer distinct possibly private data open new security breaches splitting architecture several partitions managed hypervisor way enforce isolation running virtual machines thanks high number cores architectures mitigate impact dedicating cores virtual machines hypervisor allowing efficient execution virtualized operating systems present architecture allowing execution fully virtualized multicore operating systems benefiting hardware cache coherence physical isolation made means address space via introduction light hardware module similar memory management unit network chip entrance without drawback relying page table designed cycle accurate virtual prototype architecture controlled light blind hypervisor minimum rights able start stop virtual machines experiments made virtual prototype shows solution low time overhead typically average elsevier rights reserved
anger context psychosis significant impact treatment outcomes serious implications risk management understanding mechanisms underlying anger improve interventions inform strategies prevention study first examine relationships anger key theoretical drivers across different phases psychosis continuum battery including measures theory mind attachment hostile attribution bias paranoia anger administered participants ultra high risk first episode established psychosis non clinical participants tested model insecure attachment paranoia impaired theory mind hostile attribution bias would predict trait anger using multiple regression attachment avoidance paranoia hostile attribution bias significantly associated anger attachment anxiety theory mind mediation analysis showed paranoia partially mediated relationship avoidant attachment anger hostile attribution bias findings emphasise importance interventions targeting paranoia reduce anger potential preventive strategies focused attachment relationships early life adulthood reduce adult paranoia anger
composition structure bioavailability characteristics dissolved organic nitrogen water land interface erhai lake studied using fluorescence vis absorbance moreover effect water quality also discussed results showed concentration water land interface erhai lake via yongan river concentration relatively high summer autumn inflow river input erhai lake loading erhai lake yongan river relatively high summer suggesting potential risk impact water quality erhai lake relatively large inflow river erhai lake especially summer mainly comprised humic like substances water land interface yongan river flow erhai lake showing decrease microbial degradation however aromatic proteins like dissolved metabolites microorganisms accumulated respectively extent addition humification degree gradually decreased via yongan river erhai lake moreover substitution groups aromatic rings showed transformation mainly contained aliphatic chains carbonyl carboxyl hydroxyl esters inflow river erhai lake particularly summer composition characteristic parameters iii positively correlated contents different nitrogen forms similar water land interface erhai lake via yongan river structure affect bioavailability different structural characteristic parameters water land interface erhai lake significant positive correlation water quality similar indicating composition structure bioavailability contributed water pollution water land interface yongan river input erhai lake especially greatly affected terrestrial pollution human activity summer therefore change composition structure pca water land interface yongan river lake could reflect condition water quality erhai lake extent
background ovarian cancer gynecological oncology poor prognosis high mortality study conducted identify key genes implicated prognosis bioinformatic analysis methods gene expression data including primary tissues recurrent tissues adjacent normal tissues relevant clinical information patients downloaded cancer genome atlas database data preprocessing cluster analysis conducted using consensusclusterplus package using limma package differential analysis performed identify feature genes based kaplan meier survival analysis prognostic seed genes selected feature genes key prognostic genes screened cluster analysis survival analysis performed functional enrichment analysis multivariate survival analysis using survival package cox regression analysis conducted microarray data gse validate key prognostic genes results total feature genes obtained among genes identified prognostic seed genes key prognostic genes screened including axl fos klf wdr dusp gaddb slit especially axl slit enriched ovulation cycle multivariate survival analysis showed key prognostic genes could effectively differentiate samples significantly associated prognosis additionally gse confirmed key prognostic genes associated prognosis conclusion axl fos klf wdr dusp gaddb slit might affect prognosis
environmental conservation management policy first emphasized water pollution control japan however kind passive conservation policy gradually shifted active approach satoumi includes restoration biodiversity biological productivity habitat well balanced nutrient cycle land sea many satoumi creation activities also characterized activities promote interactions land sea paper case study ago bay shima city mie prefecture japan introduced land sea interaction two sites improved promoting water exchange across dikes constructed land development land reclamation tidal flat restoration experiments conducted ago bay clearly showed promotion tidal exchange sea wetland area inner side dikes improved deteriorated sediment quality macro benthos conditions along results case study future tidal flat restoration japan also discussed published elsevier ltd
present work solid chemical sensor using mesoporous silica nanospheres scaffold applied preconcentration spectrophotometric determination iii electronic wastes digital image based colorimetric analysis also used determination concentrations metal ions fast low cost colorimetric detections quantitative chemical analysis optimum conditions analytical characteristics two methods limit detection linear range evaluated linearity obeyed range iii linear correlation coefficient new sensor displayed high sensitivity low concentrations detectable metals analytes mol solution results showed evidence thiomichler ketone tmk sensor attract worldwide attention promising technological means recovering recycling silver gold palladium elsevier rights reserved
failure instances distributed computing systems dcss exhibited temporal spatial correlations single failure instance trigger set failure instances simultaneously successively within short time interval work propose correlated failure prediction approach cfpa predict correlated failures computing elements dcss approach models correlated failure patterns using concept probabilistic shared risk groups makes prediction correlated failures exploiting association rule mining approach parallel way conduct extensive experiments evaluate feasibility effectiveness cfpa using failure traces los alamos national lab simulated datasets experimental results show proposed approach outperforms approaches failure prediction performance execution time potentially provide better prediction performance larger system
present novel image analysis based method automatically distinguishing low intermediate high grades breast cancer digitized histopathology multiple level feature set including pixel object semantic level features derived convolutional neural networks cnn extracted hematoxylin eosin stained breast biopsy tissue studies women patients multilevel features allow characterization cancer morphology also extraction structural interpretable information within histopathological images study improved hybrid active contour model based segmentation method used segment nuclei images semantic level features extracted cnn approach described proportions nuclei belonging different grades conjunction pixel level texture object level architecture features create integrated set image attributes potentially outperform either subtype features individually utilized cascaded approach train multiple support vector machine svm classifiers using combinations feature subtypes enable possibility maximizing performance leveraging different feature sets extracted multiple levels final class cancer grade detertnined combining scores produced individual svm classifiers employing light three layer cnn model parallel computing presented approach computationally efficient applicable large scale datasets method achieved accuracy low versus high low versus intermediate intermediate versus high overall accuracy discriminating low intermediate high grades histopathological breast cancer images suggested grading method could useful developing computational diagnostic tool differentiating breast cancer grades might enable objective reproducible alternative diagnosis elsevier rights reserved
order improve efficiency quality tests optimize process quality control paper deeply investigates main aspects quality tests shop floor application hierarchical model quality tests firstly set paper layout hardware network analyzed integration software shop floor application introduced advanced technology guide post time advanced technology applied quality tests discussed paper including apparatus instrument technology data acquisition communication link technology computer programming technology
one key driver linked data paradigm ability lift data graphs legacy systems employing various adapters rdfizers drq relational databases xlwrap spreadsheets approaches aim towards removing boundaries enterprise data silos opening cross organizational linking within web data insufficiently tapped source machine readable semantics underlying graph nature diagrammatic conceptual models kind information richer compared typically lifted table schemata especially domain specific modeling language employed paper advocates approach linked data enrichment based diagrammatic model rdfizer originally developed context comvantage research project minimal illustrative example provided arguments generalized leading proposed vision conceptual model aware information systems
current fed push pull converters cascaded buck pre regulator proposed voltage stress push pull switches reduced buck pre regulation pulse width modulation done switch buck stage output voltage buck inductor current controlled using average current mode control closed loop simulation cascaded buck push pull converter analog control circuit done using psim closed loop simulation using digital control circuit done using simcoupler module couples power electronic circuit psim digital control circuit matlab hardware implementation digital controllers two platforms explained switching pulses generated using digital circuit fed converter switches converter tested open loop operation
three studies conducted establish extent life drawing effective promoting positive body image study women showed life drawing positive impact state body image artists observed human model non human objects study women men showed life drawing positive impact state body image women men irrespective whether artists observed sex congruent incongruent model study showed participating weekly life drawing sessions week period resulted significantly elevated trait positive body image body appreciation body pride embodiment reduced social physique anxiety however intervention significant impact negative body image drive thinness muscularity results highlight potential life drawing promoting positive body experiences elsevier ltd rights reserved
determination conserved regions plays vital roles regulation transcription translation processes one challenging problems bioinformatics however increasing power distributed computing systems solving types combinatorial problems utilizing parallelized brute force exhaustive search algorithms recently gained popularity paper investigated parallelized implementation search tree based brute force technique find motifs different lengths experimental studies showed parallelization brute force techniques less communication overhead significantly increased usability analyze long nucleotide sequences
inhibition dipeptidyl peptidase dpp enzyme activity prevention advanced glycation end age products formation represents reliable approach achieve control hyperglycemia associated pathogenesis diabetic vascular complications frames research study several triazolo pyrazolotriazines synthesized evaluated inhibitors age products formation dpp glycogen phosphorylase glucosidase activities well age cross link breakers two considered classes heterocyclic compounds pyrazolotriazines showed highest potency antiglycating agents dpp inhibitors structure activity relationships sar compounds considered potential drugs treatment type diabetes evaluated
relationship maternal cognitive ability indicated highest attained educational level self reported numbers abortions near completed fertility investigated two population representative samples sample women sourced nlsy aged sample women aged sourced nsfg linear relationships either cognitive ability measures abortion numbers found quadratic effects present data income independent negative effect abortion numbers nsfg sample whereas age positive independent predictor nlsy sample essentially zero magnitude association maternal cognitive ability abortion numbers may resulted wide scale destigmatization elective abortion birth control technique following supreme court ruling roe wade despite self reported abortion numbers data typically underrepresent true numbers abortions hence findings must considered tentative especially underreporting unsystematic respect predictors elsevier ltd rights reserved
introduction atrial fibrillation significant impact patient mortality morbidity particular stroke frequent complication associated atrial fibrillation recent years various treatment options developed based elimination atypical electrically active atrial areas areas covered manuscript presents new cryoablation probe atricure inc addition describing characteristics probe also discuss atrial fibrillation surgical therapy options well basics cryosurgery cryoform cryoablation probe ablation system developed cardiothoracic surgeons utilizes nitrous oxide create continuous transmural lesions block propagation atrial activation main features probe excellent working capacity due use high flexibility combination cryoice box active defrost mode quick detachment expert commentary cryoform ablation probe new device treatment atrial fibrillation using energy source probe made stainless steel corrugated surface design provides higher flexibility cryoice probe
although geotextile mats considerable potential soil conservation field studies impacts soil particle size distribution nutrient conservation scant hence field experiments conducted hilton east shropshire degrees degrees study impacts palm mat geotextiles topsoil particle size distribution changes selected nutrients total geotextile mats constructed borassus aethiopum borassus palm west africa mauritia flexuosa buriti palm south america leaves termed borassus mats buriti mats respectively ten runoff plots degrees slope established duplicate treatments treatments bare soil permanent grass iii bare soil borassus mat buffer zones area coverage similar lower end plots bare soil buriti mat buffer zones area coverage similar lower end plots completely covered borassus mats initial final topsoil samples collected analysed sand fine medium coarse silt fine medium coarse clay selected nutrients results revealed soil silt clay contents significantly decreased borassus completely covered plots concomitant increase proportion sand content similar years borassus buriti buffer strip plots also lower soil clay contents indicating palm mat geotextile cover significantly affected particle size distribution even years buriti mat cover within buffer strip plots resulted notably higher decrease mean clay content concomitant increase mean sand contents compared mean clay sand contents bare soils within plots data indicate total total contents borassus completely covered plots significantly increased total content decreased similar years however except grassed plots plots significant increases total concentrations borassus buffer strip plots also significant decreases total contents initial contents increases total contents within borassus complete cover plots significantly higher grassed buriti buffer strip plots borassus buffer strip plots significantly effects changes selected nutrients total concentrations summary evident despite significant decreases soil clay total contents use borassus mats buffer strips successful conserving improving selected soil properties elsevier rights reserved
ground penetrating radar gpr electromagnetic based nondestructive geophysical tool widely used pavement investigations including differentiation pavement layers mapping layer thicknesses assessment pavement condition paper presents case study air launched gpr system consisting two truck mounted gssi antennae driven near highway speeds used investigate two segments asphalt paved roadway central missouri acquired data interpreted pavement layers differentiated variable thicknesses pavement layers mapped bulk pavement condition assessed optimum acquisition processing parameters developed core control visual assessments limited ground coupled gpr data used constrain verify reliability interpretations acquired air launched gpr data elsevier ltd rights reserved
background objective staphylococcus epidermidis autologous bacterium beneficial skin health goal develop novel personalized basic cosmetic exploits characteristic methods conducted double blinded randomized clinical trial augmentation epidermidis pilot study epidermidis collected subject cultured proliferation continuously applied subject face sleep twice per week four weeks order increase colonization levels results results showed treatment increased lipid content skin suppressed water evaporation thereby markedly improving skin moisture retention moreover augmentation epidermidis maintained low acidic condition skin surface low risk undesirable effects induced augmentation epidermidis also confirmed measuring erythema melanin levels conclusions results may serve driving force accelerate development novel personalized basic cosmetics japanese society investigative dermatology published elsevier ireland ltd rights reserved
paper deals design overall performance kwe cogeneration plant suitable local energy conversion based wide spread automotive internal combustion engine manuscript starts defining state art commercial cogenerators power underlining higher electric efficiency leads lower heat electricity ratio elevate annual service factor economic effectiveness reducing emission reported concept leaded specific choice small displacement high boosted engine terms brake mean effective pressure made obtain significant improvement engine global efficiency especially partial load compared best competitors consequently higher electric efficiency unit derived turbocharged diesel engine converted spark ignition methane natural gas system finally coupled asynchronous liquid cooled generator together high efficiency heat exchangers unconventional heat recovery devices order maximize thermal efficiency whole system placed sealed capsule expressly designed reduce heat losses noise emission tested electricity heat generation plant know running global behavior author published elsevier ltd
background bacterial srna mediated regulatory networks introduced powerful way analyze fast rewiring capabilities bacteria response changing environmental conditions identification mrna targets bacterial srnas essential investigate functional activities however step remains challenging lack knowledge topological biological constraints behind formation srna mrna duplexes even sophisticated bioinformatics target prediction tools large proportion false predictions may prohibitive analyses deal issue srna target analyses carried resulting gene lists given rna seq experiments available however number resulting target candidates may still huge easily interpreted domain experts need confront various biological features prioritize target candidates therefore novel strategies carried improve specificity computational prediction results proposing new candidates expensive experimental validation stage result address issue propose new visualization tool rnav detecting filtering bacterial srna targets regulatory networks rnav designed cope variety biological constraints including gene annotations conserved regions interaction specific patterns regulation depending application constraints variously combined analyze target candidates prioritized instance known conserved interaction region common function conclusion standalone application implements set known algorithms interaction techniques applies new problem identifying reasonable srna target candidates
many aspects human adaptation changing environment remain unanswered even substantial progress made towards better understanding populations evolution recent years paper proposes explanatory model evolutionary adaptation seems account fairly well certain qualitative dynamic patterns pointed geneticists model characterised presence feedback loops addition feedforward channels certainly present although importance feedback evolution process widely accepted today explicit representation phenomenon presented yet task humbly undertaken control engineering perspective note claim scientifically accurate simply stimulate discussion among experts delicate manifold field specifically proposed model consists four nested loops characterised different time scales embracing different spheres basis simple model considerations system stability well transient asymptotic behaviour made
symmetry sector quantum chromodynamics qcd hamiltonian analyzed previous work numerical calculations restricted particle hole space comparison experimental data reasonable spite complexity qcd spectrum low energy continue along line research show new results treatment qcd hamiltonian representation including ground state correlations means random phase approximation rpa able identify within model states may associated physical pseudo scalar vector mesons like eta eta kappa rho omega phi well pion
background discrepancy subjective objective severity depressive syndromes proposed predictor treatment outcome suicidal risk depression associated depressive cognitive distortions recent study reported evening type depressed patients showed higher depressive cognitions morning type patients therefore hypothesized genetic factors affecting evening preference carrying clock allele may influence discrepancy method tested hypothesis patients affected major depressive episode course bipolar disorder severity depression evaluated using self rated beck depression inventory bdi observer rated hamilton depression rating scale hdrs measures bdi hdrs discrepancy score calculated effects polymorphism score depressive cognitive distortions measured cognitions questionnaire examined results carriers showed higher bdi hdrs discrepancy scores homozygotes mediation analysis using bootstrapping procedures revealed dimension depressive cognition hopelessness fully mediates association polymorphism bdi hdrs discrepancy limitations many gene polymorphisms clock may also influence bdi hdrs discrepancy depressive cognitive distortions conclusion current results suggest factors affecting biological clock influence non clock psychopathological features mood disorders
background economic burden asthma relates degree control sic billion annually italy pharmacists could help improve asthma control reducing burden study aimed evaluate effectiveness cost effectiveness medicines use reviews provided community pharmacists asthma methods cluster randomised multi centre controlled trial adult patients asthma conducted regions italy september july stratification region community pharmacists randomly allocated group trained delivered intervention baseline training delivery months later using computerised random number generation blocks recruited five patients groups followed months intervention consisted systematic structured face face consultation pharmacist covering asthma symptoms medicines used attitude towards medicines adherence recording pharmacist identified pharmaceutical care issues pcis primary outcome asthma control assessed using asthma control test act score act represents good control secondary outcomes number active ingredients adherence cost effectiveness compared usual care although blinding possible either pharmacists patients assessment outcomes conducted researchers blind group allocation results numbers pharmacists patients enrolled numbers completing respectively patients similar age gender poor partial asthma control pharmacists identified pcis mean patient mostly need education monitoring potentially ineffective therapy median act score baseline differed groups odds ratio improved asthma control number needed treat number active ingredients reduced post intervention adherence improved months post intervention months probability intervention cost effective usual care months conclusions community pharmacist based intervention demonstrated effectiveness costeffectiveness since implemented first community pharmacy cognitive service italy
equine prenatal development subjected great variety effects aim study compare effects month conception month birth gestation length mares data pregnancies used conception occurred february august mares conceived early year longer gestation mares conceived later breeding season foals born january july gestation period increased mares foaled january april decreased later months mares canying male fetuses longer gestation carrying female fetuses mare age stud farm year foal birth significant influence gestation length conclusion data suggest effects month conception month foaling gestation length reverse first third year
due frequent presence comorbidities patients suffering rheumatism increased perioperative risk factors conservative treatment often needed besides pharmacological treatment physiotherapy occupational therapy variety orthoses available depending individual indications used stabilize support joints limit range motion prevent unphysiological movements provide relief affected limbs order choose right kind orthosis physician know underlying cause disease furthermore patients rheumatism many devices available daily living use ergonomic handles improved leverage effects compensate often severe limitations improve quality life
proposing three hierarchy meta frontier data envelopment analysis dea paper first decomposes emissions efficiency potential emissions reduction following three components structural technical management based components conduct empirical analysis china total factor emissions efficiency potential emissions reduction corresponding implementation path results show emissions efficiency mainland china relatively low structural inefficiency technical inefficiency management inefficiency chinese government expected realize large quantity emissions reduction potential nearly current total emissions adjusting industrial structure narrowing technology gap among regions promoting reform marketization strengthening environmental regulation causes emissions inefficiency distribution potential reductions emissions show distinct spatial difference characteristic therefore paper also formulates emissions reduction strategies china provinces according specific situations noting direction industrial structure adjustment path improving emissions efficiency
paper presents new cmos current mode ladder chebyshev elliptic band pass filters bpfs signal flow graph network transformation methods used synthesize proposed bpfs using chebyshev elliptic rlc low pass prototypes cmos based lossy lossless integrators grounded capacitors used synthesize proposed bpfs proposed filters electronically tuned khz mhz adjusting bias current filters use power supply leads low dynamic power consumption filters enjoy total harmonic distortion less along range tuning bias currents simulation results included illustrate functionality proposed filters
kinesio taping useful method last years affects prevention treatment many musculoskeletal system disorders improves sports performance also paper presents new scientific knowledge possibilities use kinesio tapes teaching physical education sport every teacher also student physical education sport know basics positive effects issue kinesio taping application prevention sports injuries musculoskeletal system frequently encountered teaching field study authors published elsevier ltd
cyber physical systems cpss consist hardware software components verify whole software hardware system meets given specifications exhaustive simulation based approaches hardware loop simulation hils effectively used first generating relevant simulation scenarios sequences disturbances actually simulating verification phase considering whole verification activity see mentioned verification phase repeated error found accordingly order minimise time taken whole verification activity verification phase ideally start simulating scenarios witnessing errors counterexamples course know beforehand set scenarios feasible paper show select scenarios minimise worst case expected verification time elsevier rights reserved
limited information exists application evidence based treatments eating disorders among diverse populations increasing number international immigrant clients provides pressing need culturally responsive treatments case study highlights eating disorder treatment incorporates dialectical behavior therapy cultural adaptation guidelines study explicates culturally adapted dialectical behavior therapy dbt treatment year old female chinese international student suffering eating disorder depression cultural adjustment issues particular case addresses chinese cultural values including conformity interdependence filial piety values intersect client presenting issues treatment cultural modifications made case conceptualization dialectical behavior therapy discussed client reported significant decrease distress increase quality social relationships increase satisfaction social roles results provide support effectiveness importance integrating cultural adaptation evidence based treatment clinical implications recommendations clinicians students provided
prospect line business services lobss infrastructure emerging sensor networks esns exciting access control remains top challenge scenario service provider server contains lot valuable resources lobss users diverse may come wide range locations vastly different characteristics cost joining could low many cases intruders eligible users conducting malicious actions result user access adjusted dynamically assessing lobss risk dynamically based frequency threat degree malicious operations therefore necessary paper proposed quantitative risk assessment model qram involving frequency threat degree based value risk quantify threat degree elementary intrusion effort amend influence coefficient risk indexes network security situation assessment model quantify threat frequency intrusion trace effort make use multiple behavior information fusion influence intrusion trace adapt historical simulation method value risk dynamically access lobss risk simulation based existing data used select appropriate parameters qram simulation results show duration influence elementary intrusion effort reasonable normalized parameter likewise time window intrusion trace weight objective risk subjective risk set respectively focus develop qram assessing risk lobss infrastructure esns dynamically involving frequency threat degree believe also appropriate scenarios cloud computing
psychologists ray blanchard anthony bogaert found evidence gay men greater number older brothers heterosexual men fraternal birth order fbo effect replicated numerous times including non western samples recently strong evidence found fbo effect prenatal origin although direct support exact prenatal mechanism plausible explanation may immunological origin mother develops immune reaction substance important male fetal development pregnancy immune effect becomes increasingly likely male gestation immune effect hypothesized cause alteration later born males prenatal brain development target immune response may molecules linked proteins surface male fetal brain cells including sites anterior hypothalamus linked sexual orientation research antibodies might bind molecules thus alter role typical sexual differentiation leading later born males attracted men opposed women review evidence favor hypothesis including recent research showing mothers boys develop immune response one linked protein antigen smcy important male fetal development immune effect becomes increasingly likely additional boy mother gives birth also discuss linked proteins may relevant hypothesis correct finally discuss issues testing maternal immune hypothesis fbo elsevier inc rights reserved
background although characterized relatively high injury rate soccer world popular sport belgium national royal belgian football association involves licensed players whose injury reports collected nationwide registry period years association introduced federation internationale football association preventive programs initiated stringent postponement policy competition case nonoptimal weather conditions hypothesis authors questioned whether preventive programs effectively decreased incidence soccer related injuries study design descriptive epidemiology study methods authors compared incidence location timing severity registered soccer injuries belgium complete seasons separated decade results total injuries reported average injuries per players per season reduction injury rate second season rate ratio confidence interval predominantly caused significant reduction injuries winter period seasons injury peak noted first months season recreational players higher risk injury national level players injuries per players per season rate ratio confidence interval relative proportion severe injuries higher female players male youth players general conclusion introduction injury preventive programs led significant reduction soccer related injuries especially winter period however still room improvement preventive programs become effective specific parameters targeted adequate conditioning players preseason
new microbent line microfiber interferometer proposed demonstrated compact temperature current sensor capable generating interference fringes high extinction ratio free spectral range wavelength employed temperature sensor copper wire carrying direct current placed sensor interference fringes sensor shifts toward longer wavelength heat generated copper wire increases temperature increase corresponds linearly current thus measurement current extrapolated well sensor temperature responsivity degrees linearity well current responsitivity degrees significant potential application health warning sensor electricity generation distribution grids
piezoelectric fans studied extensively seen promising technology thermal management due ability provide quiet reliable cooling low power consumption fluid mechanics associated piezoelectric fan similar flapping bird wing known complex paper first investigate three dimensional fluid mechanics unconfined fan operating first vibration frequency mode custom built experimental facility developed capture fan flow field using two dimensional phase locked particle image velocimetry piv fluid structure interaction also captured unique two way coupled three dimensional simulations oscillating beam beam actuated shear force resonant frequency interacts surrounding air forgoes need temporal beam displacement data experiments previous studies allowing numerical technique used independently finite element method used simulations allows two way coupling maintaining computational efficiency three dimensional lambda criterion constructed interpolated piv measurements well numerical data used identify horse shoe vortex vicinity fan evolution hairpin vortex breaks due combination vortex shedding flow along fan blade experimental numerical data comparatively agreement confirming methods presented valid capturing complex flow fields generated fluid structure interaction results provide fundamental understanding formation break vortices oscillating beam demonstrate validated approach applied development high efficiency piezoelectrically driven air moving devices extended study flapping bird uav wings
developed single walled carbon nanotubes swcnts based electrochemical biosensor detection bacillus subtilis one microorganisms observed asian dust events causes respiratory diseases asthma pneumonia swcnts plays role transducer biological antigen antibody reaction electrical signal pyrenebutanoic acid succinimidyl ester pbse ant subtilis performed chemical linker acceptor respectively adhesion target microorganism developed biosensor detection range cfu detection limit cfu developed biosensor identified response time min amount target subtilis highest specificity test developed biosensor compared tested microorganisms staphylococcus aureus flavobacterium psychrolimnae aquabacterium commune addition target subtilis detected developed biosensor observed scanning electron microscope sem analysis elsevier ltd rights reserved
recent tau computer aided design cad contest aimed seek novel ideas accurate fast common path pessimism removal cppr unnecessary pessimism forces static timing analysis tool report worse violation true timing properties owned physical circuits thereby misleading signoff timing lower clock frequency circuits operate actual silicon implementations therefore introduce paper timer powerful cppr algorithm achieves high accuracy ultrafast runtime unlike existing approaches dominated explicit path search timer proves implicit path representation amount search effort significantly reduced timer superior space time saving memory storage important timing quantities available constant space constant time per path search experimental results industrial benchmarks released tau cad contest justified timer achieved best result terms accuracy runtime existing cppr algorithms
letter identification problem bilinear forms wiener filter addressed contribution twofold first different approach introduced defining bilinear term respect impulse responses spatiotemporal model context multiple input single output systems second two versions wiener filter namely direct iterative developed context moreover advantage iterative wiener filter outlined compared direct solution results simulations performed system identification perspective support theoretical findings
activation oncogenes deactivation tumor suppressor genes long established fundamental mechanism leading towards carcinogenesis although age old axiom vastly accurate thorough study last years given unprecedented information involvement epigenetic cancer various biochemical pathways essential towards tumorigenesis regulated epigenetic phenomenons like remodeling nucleosome histone modifications dna methylation mirna mediated targeting various genes moreover presence mutations genes controlling epigenetic players strengthened association epigenetics cancer merger opened newer avenues targeted anti cancer drug therapy numerous pharmaceutical industries focusing expanding research development pipeline epigenetic drugs information provided elaborates elementary phenomena various epigenetic regulators discusses alteration associated development cancer also highlight recent developments epigenetic drugs combining preclinical clinical data signify evolving field cancer research elsevier inc rights reserved
media violence poses threat public health inasmuch leads increase real world violence aggression research shows fictional television film violence contribute short term long term increase aggression violence young viewers television news violence also contributes increased violence principally form imitative suicides acts aggression video games clearly capable producing increase aggression violence short term although long term longitudinal studies capable demonstrating long term effects conducted relationship media violence real world violence aggression moderated nature media content characteristics social influences individual exposed content still average overall size effect large enough place category known threats public health
biotherapy represents innovative therapeutic approach includes immunotherapy vaccines apheresis antibodies gene therapy stem cell transplants development helps cross bridge bench bedside brings new hope cure severe diseases different fields medicine neurology growing range applications developed medications valuable results available field autoimmunity neuro oncology paraneoplastic manifestations neuro degenerative disorders review examine current future applications biotherapy field inflammation central nervous system demonstrate contribution clinical practice enabled significant level effectiveness achieved indeed efficacy new biodrugs provides solution patients refractory standard therapies intravenous immunoglobulins limbic encephalitis plasma exchanges neuromyelitis optica anti monoclonal antibodies multiple sclerosis also mark first steps towards individualized medicine
immortalization chondrocytes enables long term vitro culture however chondrogenic capacity transformed cells varies thus highlighting need develop proliferative tuneable chondrocyte cell line hypertrophic differentiation controlled study large antigen human telomerase reverse transcriptase employed immortalize pooled equine chondrocytes lentiviral vector mediated transduction either singly combination transformed chondrocytes proliferated stably multiple passages resulted significantly lower expression chondrocyte specific collagen mrna regulation hypertrophic marker collagen three dimensional cultures cola promoter driven gfp reporter constructed real time monitoring chondrogenic differentiation significant increase promoter activation observed cultures treated growth factor tgf recapitulate native articular chondrocyte phenotype transduced large antigen immortalized chondrocytes lentiviral vectors allowing either constitutive doxycycline inducible expression sox cultures sox expressing chondrocytes secreted significantly higher levels extracellular matrix polysaccharide glycosaminoglycan regulating collagen aggrecan mrna expression systems similar patterns observed imunohistochemical staining high levels collagen mrna protein maintained constitutive sox reflecting hypetrophic differentiation significantly lower expression could achieved inducible sox conclusion immortalization equine chondrocytes results stable proliferation reduction chondrogenic potential whilst modulation sox expression enabled control hypertrophic characteristics cell biochem wiley periodicals inc
train rolling stock examination involves visual observation moving train around kmph find defective bogie parts train coach moves couple bogies consisting wheels suspension binding hardware health bogie decides safety train railway personnel perform rolling stock examination manually raising questions reliability propose use computer vision algorithms extraction localizing defective bogie parts working parts wide angle high speed camera captures moving train without motion artefacts objective use single shape prior power level set function object segmentation show bogie part segmentation one shape prior model entire length train experimentation similar train bogies different lighting tests robustness level set functional single shape prior proposed algorithm handles topological spatial deformations bogie parts video effectively segmenting defective parts non defective shape priors makes algorithm independent defect localization bogie part novel idea computer vision based rolling stock examination using high speed video lessen human errors aid developing crewless rolling stock examination proposed work extended early detection prevention rail accidents due transit part failures elsevier gmbh rights reserved
multigeneration system consists wind turbine concentrated solar collector organic rankine cycle ground source heat pump proposed analyzed assessed energetically exergetically residential applications useful outputs system electricity hot water heating cooling proposed system designed green building evaluated energy exergy efficiencies effects varying several parameters energy exergy efficiencies system investigated furthermore levelized cost electricity net present cost determined proposed system optimized based parameters optimization determines net present cost levelized cost electricity kwh energy exergy efficiencies overall system found respectively elsevier ltd rights reserved
switched affine systems sas class hybrid systems composed collection affine systems switching signal determines time instant evolving affine subsystem paper concerned observability observer design single input single output siso sas unknown perturbation case information switching signal available firstly demonstrated presence disturbances every pair always indistinguishable continuous output meaning possible infer evolving using information provided output sas nevertheless taking advantage knowledge disturbance bound new distinguishability conditions derived making possible distinguish evolving using new distinguishability conditions observer scheme siso sas subject unknown switching signal unknown perturbations presented observer scheme determines finite time evolving furthermore estimates state system disturbance finally proposed observer scheme effectively applied non autonomous chaotic modulation application attractive method spread spectrum secure communication message fed disturbance chaotic sas output transmitted open channel receiver observer algorithm recovers message disturbance output signal european control association published elsevier ltd rights reserved
background seasonal affective disorder sad characterized recurrent episodes major depression seasonal pattern therapy choice light therapy suggested administered relative chronotype patient optimal timing earlier morning evening types study aims retrospectively investigate relation chronotype effect fixed time morning population sad patients methods data four different studies conducted university center psychiatry groningen netherlands used data patients used women depression score determined structured interview sigh sad prior prior morningness eveningness preference patient determined morningness eveningness questionnaire meq patients received clinic independent chronotype results patients average meq score significant relationship meq score therapy success measured sigh sad patients divided chronotype ranging definite morning moderate evening significant relation meq score therapy success found limitations retrospective design conclusions lack significant relationship chronotype measured meq therapy success fixed timepoint may indicate anti depressive effect morning light sad patients explained phase shift biological clock elsevier rights reserved
paper describe design development deployment evaluation nooblab novel line environment teaching learning computer programming although originally devised teaching elementary javascript system also supports java php prescriptive form pseudocode designed assist teaching elementary programming concepts system incorporates number innovative features automated checking program code detection plagiarism gamification automatically logs user interactions facilitating performing learning analytics relating student engagement performance system already proved value teaching programming helping people learn program specialist computer science students also people studying engineering mathematics main subject discipline
many changes nature directly threaten humans negatively influence nature thereby posing impersonal risk examine optimistic bias impersonal risk first person perception fpp impersonal risk influence media reporting proximity impersonal risk fpp finally investigate relationship fpp conducted field experiment german cities invasive moth species infested culturally important horse chestnut trees found nature change decreased people living area subject impersonal nature risk treatments neither proximity impersonal risk journalistic style media reporting significant effect fpp found influenced significantly either different journalistic styles proximity impersonal risk nonsignificant swap signs relation fpp found depending journalistic style
tetracycline hydrochloride itch typical antibiotic widespread aqueous environment efficient cost effective removal greatly desired among various physicochemical methods ttch degradation visible light driven catalytic degradation promising one utilization solar energy bismuth oxybromide nanosheets found efficient visible light driven photocatalysts impact thickness photocatalytic activity remains unclear work first time series thickness controllable biobr nanosheets synthesized without surfactants photocatlytic degradation itch explored photocatalytic degradation itch found rely greatly generated free radicals photogenerated formed photogenerated charge carriers experimental results clearly demonstrate decrease thickness could enhance separation transportation efficiency charge carriers thinnest biobr nanosheets exhibited best performance photocatalytic ttch degradation findings might helpful expand potential applications bismuth oxybromide photocatalysts water wastewater treatment provide new strategy modification nanostructural photocatalysts elsevier rights reserved
background nowadays diagnosis sensitive skin relies subjective assessment combination subjective objective evaluation quantitative evaluation available could expected confocal microscopy imaging could interest better define condition methods total healthy female subjects recruited study firstly subjects completed sensitive questionnaire cutaneous structures measured reflectance confocal microscopy rcm face fossa cubitalia lactic acid sting test conducted finally according results self perception sensitive skin questionnaire lactic acid stinging test evaluate facial skin sensitivity positive subjects regarded sensitive skin group negative group healthy control group result results rcm indicating proportion disarranged honeycomb pattern spongiform edema sensitive group healthy control group statistically different epidermal thickness healthy control group respectively sensitive skin group healthy control group significant statistical difference two groups honeycomb structure depth sensitive group healthy control group difference statistically different two groups conclusion based rcm results epidermal honeycomb structure spongiform edema may used new skin signs rcm evaluation sensitive skin effectively indeed sensitive skin honeycomb structure depth thinner compared healthy control group specific pattern good clinical monitoring value exploration rcm could provide new data patterns evaluation sensitive skin
mirabegron first adrenoceptor agonist introduced use clinical practice extensively evaluated overactive bladder oab patients several phase iii studies however enrolled patients treatment naive experienced wash period introduction mirabegron study reported treatment results direct switch antimuscarinics mirabegron may commonly occur clinical practice observational study assess therapeutic efficacy safety directly switching antimuscarinics mirabegron patients oab receiving stable antimuscarinic treatment moreover sought identify patients benefited change patients aged years oab receiving stable antimuscarinics months enrolled antimuscarinics discontinued patients mirabegron daily initiated primary end point global response assessment gra month medication switching baseline parameters parameters changed month medication switching compared patients gra gra similar gra worse gra significantly improved storage voiding symptoms total patients maintain mirabegron without adding resuming antimuscarinics months logistic regression analysis indicated higher baseline oab symptoms scores predictor satisfactory outcome patients exhibited better outcomes switching antimuscarinics mirabegron significantly lower rates decreased pvr noted higher baseline oab symptom scores may predict better outcome
increasing need understand patient outcomes osteoporosis article discusses fracture osteoporosis lead cycle impairment driven complex psychosocial factors profound impact physical function activity accumulates time information required treatments impact physical function increasing need understand patient centred outcomes osteoporosis clinical research management multi method paper provides insight effect patients physical function everyday activity data collected three sources targeted literature review physical function conducted medline embase psycinfo secondary thematic analysis transcripts patient interviews conducted develop patient reported outcome instrument transcripts coded focus impact daily activities physical function without fracture history discussions literature review secondary qualitative analysis results three clinical experts review interpret importance implications findings results suggest particularly fracture profound impacts physical function activity impacts accumulate time cycle impairment fracture leads longer term detriments physical function including loss muscle activity avoidance reduced physical capacity turn leads greater risk fracture potential physical restrictions cycle impairment complex physical psychosocial treatment related factors comorbidities fears beliefs physical activity fracture risk influence physical function everyday activity information treatments impact physical function would benefit healthcare professionals persons making treatment decisions improving treatment compliance persistence impacts may salient patients fracture incidence
mesenchymal stem cells mscs studied extensively due potential therapeutic cell source many load bearing tissues compression tissues subsequent deformation cells one type physical strain mscs need withstand vivo mechanotransduction mscs mechanical properties partially controlled cytoskeleton including vimentin intermediate filaments ifs vimentin deficiency tied changes mechanosensing mechanical properties cells cell types however vimentin ifs contribute msc deformability comprehensively studied investigating role vimentin ifs msc mechanosensing mechanical properties assist functional understanding development msc therapies study examined vimentin ifs contribution mscs ability deform external deformation using rna interference results indicate deficient vimentin network decreases deformability mscs may caused remaining cytoskeletal network compensating vimentin network alteration observations introduce another piece information regarding vimentin ifs involved complex role cytoskeleton plays mechanical properties cells
background discovery specific antibodies astrocytic water channel aquaporin aqp produced plasma cells serum neuromyelitis optica nmo confirmed pathogenic role cells nmo motif ligand cxcl cell activating factor baff two crucial factors antibody production relevant studies focused acute phase nmo however cxcl baff levels remission remain elucidated objective evaluate serum levels cxcl baff nmo multiple sclerosis patients remission explore correlation immunosuppressive agents clinical features nmo methods serum cxcl baff measured enzyme linked immunosorbent assay elisa nmo patients patients controls results serum cxcl levels nmo patients significantly higher controls cxcl levels patients controls differ significantly although three groups showed differences serum baff levels serum baff levels nmo patients without immunosuppressive treatment significantly elevated compared nmo patients immunosuppressive therapy controls nmo patients cxcl levels correlated onset age duration last relapse conclusion remission serum cxcl baff levels decreased normal nmo patients cell related autoimmune response persists immunosuppressive therapy decreased serum baff levels affect cxcl expression
positron emission tomography pet images degraded phenomenon known partial volume effect pve approaches developed reduce pves typically utilisation structural information provided imaging modalities mri methods known partial volume correction pvc techniques reduce pves compensating effects scanner resolution thereby improving quantitative accuracy petpvc toolbox described paper comprises suite methods classic recent approaches purposes applying pvc pet data eight core pvc techniques available core methods combined create total different pvc techniques simulated brain pet data used demonstrate utility toolbox idealised conditions effects applying pvc mismatched point spread function psf estimates potential novel hybrid pvc methods improve quantification lesions anatomy based pvc techniques achieve complete recovery pet signal cortical grey matter performed idealised conditions applying deconvolution based approaches results incomplete recovery due premature termination iterative process pvc techniques sensitive psf mismatch causing bias recovery overestimating psf recovery simulated lesion improved combining two pvc techniques together petpvc toolbox written supports windows mac linux operating systems open source publicly available
attack graph depicts multiple step attack provides description system security vulnerabilities illustrates critical information necessary identify potential weaknesses areas enhanced defense attack graphs include multiple attack paths focus detailed analysis risk mitigation considering different vulnerabilities different probabilities exploited paper proposes algorithm dynamically generate top attack paths maximum probabilities every node system proposed algorithm require generation full attack graph calculate attack paths instead directly processes analyzes system input data dynamically identifies attack paths computational time based upon complexity attack paths constrained parameter experimental results show algorithm scalable efficient
paper seeks contribute growing literature children computer programming focusing programming language children kindergarten second grade sixty two students exposed week curriculum using scartchjr learned foundational programming concepts applied concepts create personally meaningful projects using scratchjr programming app paper addresses following research question scratchjr programming blocks young children choose use projects learned tailored programming curriculum data collected form students combined projects analyzed patterns differences across grades paper summarizes findings suggests potential directions future research implications use scratchjr introductory programming language young children also discussed
drug courts implemented nationwide expand alternatives incarceration individuals substance use disorders charged nonviolent felonies misdemeanors although courts publicized facilitator treatment alternative incarceration researchers advocates suggested approach may unintentionally intensified law enforcement focus casual drug users individuals minor substance dependency primary objective study determine whether evidence drug courts systemically increased arrest punishment misdemeanor drug use possession conducting series panel data analyses among city county jurisdictions controlling economic demographic nationwide law enforcement trends analyses study provide evidence local police increased attention toward minor drug offenses jurisdictions drug courts implemented across nation
using real time eye tracking gaze contingent displays modify content represent depth additional depth cues increase rendering performance omitting peripheral detail however research date exploring gaze contingent displays leveraged manipulating perceived color address conducted two experiments color matching sorting manipulated peripheral background object colors influence user color perception findings color matching experiment suggest use gaze contingent simultaneous contrast affect color appearance existing color appearance models might fully predict perceived colors gaze contingent presentation color sorting experiment demonstrate gaze contingent adjustments used enhance color discrimination gaze contingent color holds promise expanding perceived color gamut existing display technology enabling people discriminate color greater precision
visual tracking learning robust efficient appearance model challenging task model learning determines strategy frequency model updating contains many details could affect tracking results self paced learning spl recently attracting considerable interest fields machine learning computer vision spl inspired learning principle underlying cognitive process humans whose learning process generally easier samples complex aspects task propose tracking method integrates learning paradigm spl visual tracking reliable samples automatically selected model learning contrast many existing model learning strategies visual tracking discover missing link sample selection model learning combined single objective function approach sample weights model parameters learned minimizing single objective function additionally solve real valued learning weight samples error tolerant self paced function considers characteristics visual tracking proposed demonstrate robustness efficiency tracker recent tracking benchmark data set video sequences spie
insomnia common feature schizophrenia characterized increase sleep latency well reductions total sleep time tst sleep efficiency regarding sleep architecture non rapid eye movement nrem sleep slow wave sleep sws rapid eye movement rem sleep latency decreased whereas rem sleep tends remain unchanged according polysomnographic studies clozapine olanzapine quetiapine ziprasidone administration increased tst healthy subjects additionally olanzapine ziprasidone augmented sws changes corresponding rem sleep inconsistent furthermore administration clozapine olanzapine paliperidone patients schizophrenia followed instances significant reduction increase tst addition olanzapine paliperidone augmented sws rem sleep contrast quetiapine administration disrupted sleep judged increase wake time sleep onset waso rem sleep latency reduction sws rem sleep consistent effects sleep variables obtained treatment risperidone date polysomnographic studies published effects aripiprazole asenapine iloperidone lurasidone sleep either healthy subjects patients schizophrenia taken together evidence supports conclusion second generation antipsychotics sgas including clozapine olanzapine paliperidone may ameliorate insomnia patients schizophrenia elsevier ltd rights reserved
work present functional specifications architecture implementation hermophilos web based system developed auto mate accelerate accessible etextbooks production workflow management delivery higher education environment describe redesign relative manual procedures show hermophilos makes things easier faster print disabled students well personnel involved web services hermophilos include user sign user authentication user rights management students accessible textbooks quests digital textbook requests publishers requests progress monitoring original digital textbook copy submission scanning ocr version archive management copyright protection distribution digital content usage statistics implementation specifications included support browsers operating systems mobile devices accessible user interfaces wcag advanced encryption security policies hermophilos system sup ports multiple formats etextbooks plain text txt rich text rtf accessible markup xml xhtml html large print doc audio books daisy text full text full audio braille brf brl word docx portable document format pdf latex tex paperwork dramatically reduced need students visits accessibility office eliminated results show compared traditional procedure hermophilos workflow management system reduced overall production delivery time
background studies published association mental disorders violence based general population studies focus different types violence adjusting violent victimization taking account limitations previous population studies method data used first two waves netherlands mental health survey incidence study nemesis nationally representative face face survey general population aged years violence differentiated physical psychological violence intimate partner children person general dsm diagnoses assessed composite international diagnostic interview version cidi results psychological violence occurs considerably frequently physical violence showed almost identical associations mental disorders adjustment sociodemographic characteristics main categories common mental disorders associated violence strongest associations found externalizing disorders substance use impulse control antisocial personality disorder additional adjustment violent victimization negative life events social support diagnostic correlates lost significance whereas substance use particular alcohol disorders still associated types violence conclusions increased risk violent offending among people common mental disorders substance use disorders attributed factors mental illness
ability store urine bladder void appropriate time depends several complex mechanisms lower urinary tract lut neural control normal lut function requires coordination urinary bladder urethra pelvic floor efferent afferent neurons specific spinal cord brain areas structures visualised using different imaging modalities ultrasound ray magnetic resonance imaging supraspinal neural control lut studied using functional brain imaging last two decades many technological improvements imaging techniques increased knowledge voiding dysfunction review different imaging modalities lut neural control discuss importance diagnosing understanding voiding dysfunction elsevier rights reserved
fast retrieval archival traffic data essential network security forensic analysis bitmap index data structure enabling fast search large data collections limited time space consumption always problem wah plwah compax proposed compressing bitmap indexes less storage paper new bitmap index encoding scheme named masc proposed improve compression ratio without impairing query performance instead limited fixed length bits plwah compax stride size long possible encode consecutive zero bits nonzero bits compact way instead piggyback used plwah new structure masc called carrier introduced piggyback plwah carries individual nonzero bit also generalize traditional literal word concept plwah compax validity masc encoding scheme demonstrated application internet traffic archival system based experiments real internet traffic data set caida masc better compression ratio plwah compax without penalty query performance
protein arginine deiminases pad implicated variety inflammatory neurodegenerative diseases including multiple sclerosis following discovery silico hit containing hydantoin piperidine moiety hypothesized carbon linker hydantoin would necessary membered heterocycle optimal pad inhibitory activity designed thirteen compounds potential inhibitors pad pad enzymes two important pad enzymes implicated two compounds one imidazole moiety tetrazole moiety showed good inhibition pad isozymes vitro eae mouse model vivo experiments suggested compound non covalent inhibitor pad pad exhibits dose dependent efficacy eae mouse model cuprizone mediated demyelination model elsevier ltd rights reserved
metadata management essential enabling factor geospatial assets discovery retrieval actual usage latter tightly bound quality descriptions unfortunately multi faceted landscape metadata formats requirements conventions makes difficult identify editing tools easily tailored specificities given project workgroup community practice solution template driven metadata editing tool customised xml based schema output constituted standards compliant metadata records also semantics aware counterpart eliciting novel exploitation techniques moreover external data sources easily plugged provide autocompletion functionalities basis data structures made available web data beside presenting essentials customisation editor means two use cases extend methodology whole life cycle geospatial metadata demonstrate novel capabilities enabled rdf based metadata representation respect traditional metadata management geospatial domain
taking inhomogeneities media nonuniform boundaries account variable coefficient equations describe realistic physical phenomena constant coefficient counterparts paper variable coefficient forced kadomtsev petviashvili equation inhomogeneous nonlinearity dispersion perturbed term external force investigated using modified dependent variable transformation equation first bilinearized soliton solutions two different kinds determinant structure wronskian grammian determinant soliton solutions variable coefficient forced kadomtsev petviashvili equation presented verified certain coefficient constraints sample soliton solutions given choosing suitable determinant elements several kinds soliton evolution situations discussed illustrated elsevier rights reserved
early neuropathological changes characteristic late onset alzheimer disease load involve brain stem limbic structures regulate neurovegetative functions including sleep wake rhythm indeed sleep pattern emerging biomarker potential pathophysiological mechanism load hypothesized cognitively asymptomatic middle aged offspring patients load load would display series circadian rhythm abnormalities prior onset objective cognitive alterations tested children patients load load healthy individuals without family history alzheimer disease control subjects basic tests cognitive function well actigraphy measures sleep wake rhythm cardiac autonomic function bodily temperature unexpectedly load displayed subtle significant deficits verbal episodic memory rey auditory verbal learning test delayed recall language weschler vocabulary compared even though participants results within clinically normal range load showed phase delayed rhythm body temperature cognitive performance load associated series cardiac autonomic sleep wake variables specifically indicators greater sympathetic activity night related poorer cognition present results suggest sleep pattern deserves study potential neurobiological signature load even middle aged risk individuals
expected population growth result increasing water demand consequences could potentially jeopardise water resource availability especially urban areas significantly increase costs rainwater harvesting rwh systems aid meeting water demand partially also cost effective environmentally friendly manner techniques although reduction environmental burdens fairly obvious question urban planners consumers remains rwh systems economically feasible paper investigates cost effectiveness eight different scenarios metropolitan area barcelona monetary investment quantified provide rainwater laundry purposes results indicate high density scenarios financially suitable choices higher net present value shorter payback time given users mean savings laundry additive consumption studies consider variables greater effect financial appraisal similar inflation rate specific attention paid costs associated storage tank location included savings side tap water consumption effect water bill along special attention tap water prices area study
software defined networking sdn relies open programmability network devices achieved defining new communication interfaces network operating systems changing traditional decision making logic regular tcp networks network functions virtualization nfv turn permits virtualizing network functions traditionally performed physical middleboxes firewalling intrusion detection prevention although sdn nfv improve flexibility management computer networks sdn remains vulnerable major network security problems distributed denial service ddos attacks attacks typically result disruption network services resources paper introduce answer architecture combines nfv sdn features create sophisticated network resilience strategies answer relies feedback control loop explores sdn features monitor analyze behavior network infrastructure indicating whether parts existing resilience strategy reconfigured achieve satisfactory results entire resilience strategy needs added replaced experiments demonstrate answer rapidly identify handle distinct anomalies different scenarios indicating reconfiguration deployment resilience strategies performed real time
paper proposes new state space formulations iir variable digital filters vdfs based frequency transformations existing frequency transformation based state space vdfs require restrictions transfer functions state space representations tuning characteristics hand proposed method free restrictions achieve goal applying series approximations conventional state space formulations frequency transformations approach also allows realize proposed vdfs without complicated computations inverse matrix square root furthermore proposed vdfs show high accuracy respect finite wordlength effects well approximation errors elsevier inc rights reserved
attentional scope model rumination predicts rumination associated narrowed attentional scope magnifies emotional responding reduces problem solving study examined prediction using moving window paradigm allowing direct measurement attentional scope perceptual level high low trait ruminators asked read self related related sentences small medium large moving window conditions visual fixations reading recorded results showed significant group differences small window size condition high rumination group processing faster making fewer fixations reading sentences analyses confirmed differences remained controlling mood state level depression findings indicate people high levels trait rumination characterized narrower attentional scope processing information clinical implications relation rumination discussed elsevier rights reserved
brain neocortex anatomically organized grey white matter mainly composed neuronal glial cells respectively neocortex divided different brodmann areas according cytoarchitectural organization associated distinct cortical functions increasing evidence brain development function governed epigenetic processes yet contribution functional organization neocortex remains incompletely understood herein determined dna methylation patterns grey white matter dorsolateral prefrontal cortex brodmann area important region higher cognitive skills particularly affected various neurological diseases avoiding interindividual differences analyzed white grey matter donor using whole genome bisulfite sequencing validating biological significance used infinium humanmethylation beadchip pyrosequencing ten twenty independent samples respectively combination analysis indicated robust grey white matter differences dna methylation cell type specific markers enriched among differentially methylated genes interestingly also found outstanding number grey white matter differentially methylated genes previously associated alzheimer parkinson huntington disease well multiple amyotrophic lateral sclerosis data presented thus constitute important resource future studies gain insight brain regional well grey white matter differences also unmask epigenetic alterations might underlie neurological neurodegenerative diseases
energy solvent regeneration post combustion carbon capture pcc process typically provided steam bleeding power plant steam cycle energy penalty steam bleeding results serious reduction capacity estimated range power plant repowering hybridization using solar assisted pcc spcc promising approach satisfy carbon capture targets well load concurrently drawback methodology notable amounts solar energy wasted heat transfer solar radiation rich solvent paper presents novel approach eliminating costly desorber system using solar collector pipe parabolic trough pipe directly heat rich solvent disassociate bonds solvent novel technology lowers process capital expenditure also reduces solvent regeneration energy bringing close theoretical values elimination complex desorber column also increases flexibility operation response market dynamics case study sydney australia shows comparison spcc methodology state art approach could notably improve economics process reduce size solar collector field scf elsevier ltd rights reserved
depressive disorders among common mental illnesses around world prepubertal children postpubertal children adolescents affected markedly impair psychosocial development associated higher rate morbidity mortality throughout life many physicians unsure treatment approaches effective treatment planned systematic literature search carried electronic databases study registries manual search studies mostly randomized controlled trials rcts identified summarized evidence tables ensuing recommendations agreed upon consensus conference review summarizes evidence complementary treatment methods evidence complementary treatment methods art music therapy sleep deprivation exercise electroconvulsive therapy massage transcranial magnetic stimulation relaxation bibliotherapy computer based therapy light therapy omega treatment low evidence due missing studies studies poor quality methods light therapy relaxation stress reduction sleep deprivation limited indication effectiveness without sufficient evidence practical guidance urgent need adequately informative comparative studies treatment depression children adolescents considering also complementary methods
objectives evidence supports girls less proficient boys performing ball skills study examined immediate long term effects ball skill intervention preschool age girls ball skill performance design randomized controlled trial methods girls age months randomly assigned high autonomy mastery based week motor skill intervention children health activity motor program champ min control group free play ball skill proficiency assessed pretest posttest retention test weeks using object control subscale test gross motor development edition treatment efficacy examined using linear mixed models two models fit one short term changes pretest posttest one long term changes pretest retention results linear mixed models revealed significantly time treatment interaction models post hoc analysis confirmed girls champ experienced significant gains ball skills pretest posttest pretest retention significantly higher ball skills scores posttest retention conclusions study demonstrates positive effects ball skill intervention champ improving girls ball skills short long term findings suggest early childhood interventions focus development ball skills young girls might avenue improve girls ball skill performance sports medicine australia published elsevier ltd rights reserved
computer aided diagnosis cad parkinson disease using structural magnetic resonance imaging emerging research field pattern recognition community existing research works utilized gray matter white matter cerebrospinal fluid tissues individually diagnosis ignored intercorrelation among three tissues thus need define fused feature descriptor ffd capture information intercorrelation three tissues simultaneously enhance performance cad present study proposes simple efficient ffd terms three tissues cad brain volume represented terms ffd fused volume segmented brain regions thereafter features extraction carried brain region using local binary pattern set discriminating uncorrelated features identified using test conjunction minimum redundancy maximum relevance feature selection method finally support vector machine utilized build decision model volumetric weighted magnetic resonance imaging dataset age gender matched healthy subjects acquired using machine utilized investigate efficacy proposed method classification accuracy achieved using leave one cross validation scheme superior existing methods regions namely hippocampus cingulum mid frontal inf tra precentral precentral frontal mid frontal mid orb cingulum ant hippocampus observed discriminative regions diagnosis notable performance proposed method suggests instead studying three tissues independently intercorrelation also considered proposed method may employed diagnostic tool diagnosis elsevier ltd rights reserved
background objective study assess anxiety depression panic disorders among patients diagnosed copd investigate correlation disease severity quality life well tobacco use methods observational study performed january september among patients diagnosed copd copd staging according gold criteria anxiety depression assessed using hospital anxiety depression scale panic attacks evaluated based icd criteria results almost sample smokers medium packs years medium fagerstrom score overall mean modified medical research council dyspnea scale mmrc mean copd assessment test cat score study participants copd exacerbations year mean distribution anxiety depression symptoms scores among copd subjects respectively smokers smokers similar scores regard anxiety depression presence panic attacks results bivariate correlations indicated associations anxiety depression panic attacks disease severity well poor quality life patients copd regardless current tobacco use status conclusions conclusion results study indicate anxiety depression panic attacks constant characteristics among copd patients regardless current tobacco use
impedance cardiography used monitor pumping function heart terms stroke volume cardiac output explored extent used monitoring transient effects cardiac alterations beat beat basis four spot electrode configuration used present design spatial arrangement four electrodes carefully selected obtain optimal result constant current source provided khz sinusoidal excitation current analog signal processing developed demodulate amplify resultant impedance information eliminate low frequency motion artifacts incidental breathing artifacts experiments performed normal healthy volunteers impedance waveforms recorded subject beginning supine position moving upright position breath holding maintained throughout procedure impedance waveform first derivative component electrocardiogram recorded simultaneously continuously results showed significant increase relative impedance levels supine transient state decreased upright position additionally supine position higher max sitting resulting reduction stroke volume increased impedance supine sitting verified physiological findings obtained others results investigation illustrate ability impedance cardiography effectively monitor dynamic cardiovascular function transient conditions
background cerebral autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy cadasil inherited cerebral microangiopathy presenting variable features including migraine psychiatric disorders stroke cognitive decline variable disability neuroimaging cadasil characterized leukoencephalopathy multiple lacunar infarcts microbleeds previous studies suggest possible role endothelial impairment pathogenesis disease methods assessed plasma levels von willebrand factor vwf thrombomodulin blood levels endothelial progenitor cells epcs circulating progenitor cells cpcs cadasil patients age matched controls association clinical functional neuroimaging features results multivariate analysis cadasil patients significantly higher vwf lower epc levels levels similar groups cadasil patients severe clinical phenotype history stroke dementia presented lower cpc levels comparison patients milder phenotype correlation analysis lower cpc levels associated worse performances neuropsychological motor functional tests higher lesion load brain magnetic resonance imaging degree leukoencephalopathy number lacunar infarcts conclusions first cadasil series multiple circulating biomarkers studied findings support previous studies presence possible modulating effect endothelial impairment disease furthermore research data suggest blood cpcs may markers disease severity
objective describe parenting self efficacy family empowerment among expectant mothers substance use disorders design study employed quantitative cross sectional design participants participants pregnant women substance use disorders entering gender specific substance use disorder residential treatment facility measurements measurement tools included demographic data form parenting sense competence scale addiction severity index family empowerment scale findings women third trimester reported statistically significant higher levels parenting self efficacy family empowerment women first trimester key conclusions interventions promote parenting self efficacy family empowerment need target women first trimester implications practice midwives specialized training substance abuse disorders unique position bolster expectant mothers parenting capabilities addiction recovery process
currently ambient assisted living ambient intelligence areas prolific demand security comfort ensured people homes aalall ambient assisted living project aims develop unified ecosystem certification process allowing development fully compatible devices services useraccess emerges aalall project demonstration validity useraccess architecture implementation interfaces test scenario presented along sensor platform specially developed aalall project
background people admitted psychiatric hospitals diagnosis schizophrenia may display behavioural problems may require management approaches use coercive practices impact wellbeing staff members visiting families friends peers well patients studies proposed patients conditions also treatment environment ward culture may affect patients behaviour seclusion restraint could possibly prevented staff education user centred humane approaches staff education could also increase collaboration patients family members staff may positively affect treatment culture lower need using coercive treatment methods methods single blind two arm cluster randomised controlled trial involving psychiatric hospital wards across finland units randomised receive either staff educational programme delivered team researchers standard care primary outcome incidence use patient seclusion rooms assessed local national health registers secondary outcomes include use coercive methods limb restraint forced injection physical restraint service use treatment satisfaction general functioning among patients team climate employee turn nursing staff discussion study designed close collaboration staff members patients relatives provide evidence operative user centred educational intervention aiming decrease prevalence coercive methods service use units increase functional status patients improve team climate units identified similar trials
clarify outcome allogeneic hematopoietic cell transplantation hct leukemic transformation preceded philadelphia chromosome negative neg myeloproliferative neoplasms mpns conducted retrospective study using national registry database japan society hematopoietic cell transplantation patients underwent first allogeneic hct related bone marrow peripheral blood stem cells unrelated bone marrow unrelated umbilical cord blood median patient age years underlying neg mpns included cases essential thrombocythemia cases primary myelofibrosis cases polycythemia vera median interval diagnosis transplantation days thirty two cases remission time transplantation year overall survival rate confidence interval median follow surviving patients days range cumulative incidences relapse nonrelapse mortality years respectively study results suggested allogeneic hct provides long term survival approximately one third patients preceded neg mpns american society blood marrow transplantation
swimming exercise optimal speed may optimize growth performance yellowtail kingfish recirculating aquaculture system therefore optimal swimming speeds opt body lengths assessed applied determine effects long term forced sustained swimming opt growth performance juvenile yellowtail kingfish uopt quantified blazka type swim tunnels juveniles resulting values combined literature data larger fish relation opt established species yellowtail kingfish either forced perform sustained swimming exercise optimal speed swimmers allowed perform spontaneous activity low water flow resters newly designed oval flume flow created impeller driven electric motor compared start experiment ten fish sampled representing initial condition days swimmers showed greater increase greater increase bvv compared resters groups fed equal rations feed conversion ratio fcr swimmers resters doppler ultrasound imaging showed statistically significant higher blood flow ventral aorta swimmers resters min respectively anesthesia thus growth performance rapidly improved optimal swimming without larger feed investments
cationic copolymer emulsions gma successfully synthesized via semi continuous emulsion polymerization properties synthesized cationic emulsions characterized monomer conversion solid content differential scanning calorimeter particle size distribution zeta potential centrifugal stability film performance cationic emulsions formed cotton fiber surface observed scanning electricity microscopy influence cationic emulsions color data values rubbing fastness dyed cotton fabrics also investigated results show aagma emulsion larger particle size higher zeta potential emulsion films formed room temperature gma emulsion film better performance emulsion film addition gma monomers improved film performance gma emulsion films formed degrees acetic acid solution treatment best water resistance dyed cotton fabrics pretreated gma emulsion better pigment dyeing performance pretreated emulsion demonstrates addition gma monomers improved effect pigment dyeing cotton fabrics cationic emulsions binders increase gma concentration color performance dye fabrics improved rubbing fastness decreased little handle fastness still meets use standards consumers wiley periodicals inc
angioimmunoblastic cell lymphoma follicular helper derived neoplasm displaying peculiar morphologic appearance biological complexity new mutations described contribute elucidating underlying pathogenetic events disease behaves aggressively typically affects elderly patients outcomes reported anthracycline containing regimens poor therefore autologous transplantation first remission offered whenever possible newer approaches urgently needed relapsed refractory patients newly approved agents show activity pretreated patients response durations short innovative induction strategies chop biologic agent designed enhance response quality facilitate transplantation prolong survival
constant development economy country recent years role network technology contemporary society become prominent network become indispensable important information tool modern people daily life work cloud computing technology new kind computer technology although provide convenient service people time also hidden danger network security therefore strengthen construction enterprise network security management system cloud computing technology particularly important article elaborates important role cloud computing technology plays safe operation enterprise network security management system exploring specific role computing technology plays construction enterprise network security management system putting forward strategies perfect enterprise network security management system computing technology based overview cloud computing
predatory efficiency squid cuttlefish superorder decapodiformes enhanced robust sucker ring teeth srt perform grappling functions prey capture show srt composed entirely related structural suckerin proteins whose modular designs enable formation nanoconfined beta sheet reinforced polymer networks thirty seven previously undiscovered suckerins identified transcriptomes assembled three distantly related decapodiform cephalopods similarity modular sequence design exon intron architecture suggests suckerins encoded multigene family phylogenetic analysis supports view revealing suckerin genes originated common ancestor similar mya indicating nanoconfined beta sheet reinforcement ancient strategy create robust bulk biomaterials ray diffraction nanomechanical micro raman spectroscopy measurements confirm modular design suckerins facilitates formation beta sheets precise nanoscale dimensions enables assembly structurally robust supramolecular networks stabilized cooperative hydrogen bonding suckerin gene family likely played key role evolutionary success decapodiform cephalopods provides large molecular toolbox biomimetic materials engineering
background difficulty emotion regulation hallmark feature patients borderline personality disorder bpd therefore change frequency certain patient coping strategies aiming emotion regulation among promising mechanisms change treatments bpd parallel highlighted therapist responsiveness significantly contributed outcome across treatment approaches stiles based randomized controlled trial kramer present process outcome mediation analysis aims examining patient early change frequency coping strategies particular decrease behavioral forms coping potential mechanism change responsive treatments bpd method total patients bpd included present analysis randomly assigned session psychiatric treatment session psychiatric treatment augmented responsive intervention motive oriented therapeutic relationship caspar session therapy transcribed analyzed using coping action pattern rating scale perry sessions analyzed total validated observer rated method assessing coping strategies therapy process psychological distress assessed using intake session session results results confirmed responsiveness effect associated motive oriented therapeutic relationship showed significant decrease frequency behavioral forms coping different conditions addition demonstrated early decrease behavioral forms coping sessions partially mediated link group assignment change psychological distress sessions conclusions results shed light centrality therapist responsiveness treatments bpd impact early change patient session behavioral coping strategies contributing effectiveness short term treatments bpd
case report legal case revolving around reliability statements given year old girl described claimed witnessed mother murdered father two psychological experts provided diametrically opposed opinions reliability statements one expert clinician opined girl statements based autosuggestion whereas expert memory researcher stated autosuggestion unlikely played role case analysis experts opinions illustrate may happen experts court unaware recent literature false memory recent studies show autosuggestion less likely occur young children older children adults current case stresses importance implications relying memory experts cases concerning reliability eyewitness statements
one side pricing services cloud computing plays crucial role generating revenues large scale adoption within masses whereas hand security one main issues cloud computing assure people trustworthiness reliability pricing security services cloud computing even becomes significant area research security pricing cloud computing fixed provider driven pay end user pay fixedly amount security capabilities role deciding security capabilities actually required based significance paper focused proposing user driven security pricing strategy incorporates user oriented characters like utility satisfaction economically better pricing strategy perspective users
sufficient first aid equipment essential treat injuries football fields deficits first aid field still present youth football injury pattern youth football one season first aid equipment youth football analyzed retrospectively price abc procedure served basic principles emergency management assess need first aid equipment field considering financial limits adapted youth football injuries sufficient first aid equipment youth football configured participating youth football teams first aid kit majority insufficiently equipped team coaches youth teams responsible using first aid equipment injury evaluation presented injuries youth players one season frequently presented types injury contusions sprains lower extremity based analyzed injury data youth football first aid equipment sign sufficient occurred youth football injuries current first aid equipment youth football insufficient scientific based first aid equipment sign adequate serve injuries football coaches need education first aid management
paper propose sopc based multiprocessor embedded system controlling ambiental parameters intelligent inhabited environment intelligent features achieved means neuro fuzzy system ability learn samples reason adapt changes environment user preferences particular modified version well known anfis adaptive neuro fuzzy inference system scheme used allows development efficient implementations architecture proposed based two soft core microprocessors one microprocessor dedicated learning adaptive procedures whereas dedicated online response second microprocessor endowed efficient hoc hardware modules intended accelerate neuro fuzzy algorithms implementation carried xilinx virtex fpga obtained results show high performance system achieved elsevier rights reserved
present investigation series model tests performed study effect different governing parameters viz relative density sand ratio embedment depth anchor diameter bell anchor number ties ratio length tie diameter bell anchor diameter bell anchor friction ratio psi center dot uplift capacity anchor ties embedded river sand experiment observed increase ratio ultimate uplift capacities anchor without ties increase increase number tie layers ultimate uplift capacity anchor ties increases non linear power model developed predict ultimate uplift capacity rult anchor ties terms ultimate uplift capacity anchor without tie ratio ratio
online social networks osns gradually integrate financial capabilities enabling usage real virtual currency serve new platforms host variety business activities online promotion events users possibly get virtual currency rewards participating events osns business partners significantly concerned attackers instrument set accounts collect virtual currency events make events ineffective result significant financial loss becomes great importance proactively detecting malicious accounts online promotion activities subsequently decreases priority rewarded paper propose novel system namely proguard accomplish objective systematically integrating features characterize accounts three perspectives including general behaviors recharging patterns usage currency performed extensive experiments based data collected tencent global leading osn built financial management activities experimental results demonstrated system accomplish high detection rate low false positive rate
experimentally test social motives behind individual participation intergroup conflict manipulating perceived target threat groups individuals symmetry conflict find behavior conflict depends whether one harmed actions perpetrated group one influence outcome group perceived target threat dramatically alters decisions participate conflict people perceive group threat mobilized good group contribute conflict hand people perceive personally threat driven good withhold contribution first phenomenon attributed group identity possibly combined concern social welfare second phenomenon attributed novel victim effect another social motive reciprocity ruled data elsevier rights reserved
background roux gastric bypass rygb one widely performed bariatric surgeries world performing rygb vinci surgical system new advancement aim study describe single docking single quadrant technique short term results materials methods january december robotic rygb performed rygb performed single docking single quadrant approach data analysed retrospectively intra post operative details every patient documented follow done per protocol months years total patients completed follow protocol per database results mean age patients years ratio males females equal mean operative time min early mortality seen days post surgery two late complications documented late mortality average length stay days average blood loss hospital admission surgery conclusion single docking single quadrant technique simple effective time saving without complicated port position multiple docking minimal complications
report design measurements multichannel asic fsdr prototype implemented umc cmos technology dedicated readout silicon strip detectors fsdr chip contains channels size built charge sensitive amplifier pole zero cancellation circuit order complex shaper based follow leader architecture bit trim dac achieve low noise performance high speed analog signal processing proper signal shaping involved order obtain voltage pulse symmetrical short possible shaper output functionality chip allows make comparison typical shaper based real poles complex semi gaussian shaper based complex poles present design procedure filters measurements results emphasis spread analog front end parameters architectures multichannel system fsdr chip characterizes low power dissipation diss per single channel peaking time measured peak complex semi gaussian shaper set fast mode slow mode architecture allows obtain shorter pulse width measured form curve case typical shaper front end electronics optimized detector capacitance det fast mode complex semi gaussian shaper equivalent noise charge enc slow mode enc
psychosocial conditions depression intimate partner violence ipv history childhood sexual abuse csa associated poor hiv related outcomes india third largest hiv epidemic world little understood impact psychosocial conditions people living hiv plhiv aimed understand prevalence correlates psychosocial conditions among plhiv entering hiv care gaitonde centre aids research education chennai india thirteen questions added standard voluntary counseling testing questionnaire including patient health questionnaire depression scale questions assessing csa ipv fitted logistic regression models stratified gender psychosocial condition outcome interest substance use variables socio demographic variables correlates interest three hundred eighty three persons enrolled study tested positive hiv including men women included models one quarter men women reported least one psychosocial condition probable depression csa ipv adjusted analysis current alcohol use associated greater two times higher odds psychosocial condition adjusted odds ratio among men conclusion estimated prevalence probable depression csa ipv among plhiv presenting hiv care southern india found among male plhiv alcohol use associated markedly higher odds reporting psychosocial condition study needed characterize alcohol use among male plhiv possible deleterious impact psychosocial conditions alcohol use hiv related outcomes india
repetitive patterns strategies manipulating source code example modifying source code acquiring knowledge code works depth first style reading understanding modifying source code breadth first style extent know study influence personality objective study understand influence personality programming styles correlational study programmers university stuttgart academic achievement programming experience attitude towards programming five personality factors measured via self assessed survey programming styles asked survey mined software repositories performance programming composed bug proneness programmers mined software repositories grades got software project course estimate programming ability statistical analysis found openness experience positive association breadth first style conscientiousness positive association depth first style also found addition programming experience better academic achievement styles working depth first saving coarse grained revisions improve performance programming elsevier inc rights reserved
background topical corticosteroid calcineurin inhibitor similar therapeutic benefits atopic dermatitis differences therapeutic mechanisms action agents symptoms fully understood objective study performed examine different effects topical betamethasone valerate bmv clobetasol propionate cbp tacrolimus tac itch related behavior dermatitis nga mice like symptoms methods like dermatitis induced dorsal skin nga mice repeated topical application dermatophagoides farinae body dfb ointment twice weekly three weeks mice dermatitis scores divided five groups equal dermatitis scores treated bmv cbp tac vaseline vas daily two consecutive days treated scratching behavior analyzed using sclaba real system transepidermal water loss tewl treatment measured using tewameter skin collected group analyzed histologically results second treatment dermatitis showed significantly greater improvement cbp tac treated groups vas treated groups numbers scratching bouts significantly lower cbp tac treated mice vas treated mice tewl significantly lower tac cbp treated mice vas treated mice immunohistochemical examination showed bmv cbp tac reduce increased densities epidermal protein gene product substance immunoreactive fibers numbers dermal immunoreactive cells significantly lower bmv cbp treated mice vas treated mice numbers dermal eosinophils significantly lower bmv cbp tac treated mice vas treated mice cbp showing strongest effect cbp significantly reduced epidermal thickness compared vas significant differences numbers interleukin immunoreactive cells mast cells expression epidermal thymic stromal lymphopoietin among five groups conclusion therapeutic potency tac like symptoms including pruritus equal corticosteroid cbp epidermal innervation sensory nerves might related therapeutic effects topical tacrolimus corticosteroids early phase japanese society investigative dermatology published elsevier ireland ltd rights reserved
hereditary angioedema autosomal dominant life threatening disorder characterized recurrent episodes non pitting edema affecting skin respiratory system digestive tracts caused congenital deficiency function defect esterase inhibitor preseptal cellulitis defined infection tissues anterior orbital septum generally caused complications upper respiratory tract infection dacryocystitis dermal infection rarely sinusitis disease presents orbital pain edema eyelids erythema fever case child hereditary angioedema type presented mimicking complication acute sinusitis discussed elsevier ireland ltd rights reserved
paper studies temporal behavior communication flows internet characterization flows temporal patterns supports traffic classification filtering network management network security situations full packet data pot accessible obfuscated encrypted traffic analyzed due privacy concerns resource limitations paper define time activity feature vector describes temporal behavior flows later use cluster analysis capture common time activity patterns real internet traffic using traces mawi dataset discovered set seven time activity footprints show analyzed flows characterized based footprints represent different behaviors three main protocols tcp icmp udp addition found majority observed flows consisted short one time bursts depth inspection revealed besides dns traffic preponderance large number scanning probing dos attacks backscatter traffic network flows transmitting meaningful data became outliers among short one time bursts unwanted traffic elsevier rights reserved
aiming improving poor real time performance existing nonlinear filtering algorithms applied spacecraft autonomous navigation based global positioning system gps measurements simplifying algorithm design navigation algorithms spacecraft autonomous navigation algorithm based polytopic linear differential inclusion proposed paper firstly demonstrated nonlinear estimation error system spacecraft autonomous navigation modelled polytopic linear differential inclusion system model according idea global linearization thus filtering nonlinear system simplified filtering polytopic linear system coefficients secondly tensor product model transformation applied determine polytopic linear differential inclusion system model model error introduced global linearization reduced compromise computational complexity modelling accuracy realised finally spacecraft autonomous navigation algorithm based polytopic linear differential inclusion designed combining multi model kalman filtering data fusion compared extended kalman filter ekf proposed algorithm simpler easier implement since need update jacobian matrices online simulation results demonstrate estimation accuracy proposed algorithm ekf
aimto assess quality evidence determine effect patient related economic outcomes self management support interventions chronically ill patients low socio economic status backgroundintegrated evidence self management support interventions chronically ill people low socio economic status lacking designsystematic literature review data sourcescochrane database trials pubmed cinahl web science psycinfo joanna briggs institute library searched randomized controlled trials addressing self management support interventions patients cardiovascular disease stroke cancer diabetes chronic respiratory disease included review methodsdata extraction quality assessment performed independent researchers using data extraction form resultsstudies focused mainly diabetes fourteen studies cited underlying theoretical basis frequently used self management support components lifestyle advice information provision symptom management problem solving goal setting strategies frequently integrated eleven studies adapted interventions needs patients low socio economic status differences found interventions developed based health behaviour theoretical models conclusionlimited evidence found self management support interventions chronically ill patients low socio economic status essential characteristics component effective self management support interventions patients could detected rigorous reporting development underlying theories intervention recommended
acute angioedema attacks conventionally treated antihistamines steroids line presumed mechanism disease involving overwhelming mast cell degranulation approach overlooks small important minority cases attacks bradykinin driven exhibit poor responsiveness steroid anti histamine therapy patients may family history angioedema hereditary angioedema past medical history including cell lymphoproliferative disorders autoimmune disease acquired angioedema rather steroid therapy respond administration bradykinin inhibitor commonly esterase inhibitor substitute control acute symptoms reduce probability invasive airway insertion long term require esterase inhibitor sparing therapy treat cause approach reduce risk recurrent attacks present case middle aged woman presented recurrent angioedema initially uncertain aetiology
outcomes related disordered metabolism common alcohol dependence investigate alterations regulation body mass occur context performed genome wide association study gwas body mass index bmi african americans aas european americans eas subjects recruited genetic studies drug dependence evaluated using semi structured assessment drug dependence alcoholism investigated total aas eas dsm diagnosis stage sample observed three genome wide significant gws single nucleotide polymorphism associations eas aas eas meta analyzed stage sample replicated stage suggestive loci aas eas aas eas meta analyzed respectively meta analysis stage stage samples identified two additional gws signals eas aas three gws loci identified previously reported gwas bmi general population two raise interesting hypotheses regulatory variant located within linc gwas identified variants associated birth size adiposity newborns bulimia symptoms also interact social stress relation birth size regulatory variant related aldha gene involved alcohol metabolism adipocyte plasticity loci offer molecular insights regarding regulatory mechanisms body mass context
individuals long term marriages report intensities romantic love comparable individuals newly love common correlates long term romantic love consistent theoretical models love random sample married individuals married years reported intensely love importantly correlates long term intense love predicted theory thinking positively partner thinking partner apart affectionate behaviors sexual intercourse shared novel challenging activities general life happiness wanting know partner times correlated significantly intense love men women women men passion nonrelationship factors significantly correlated intense love random new york sample individuals married years reported intensely love predicted correlates cross validated
sustainable building green building strategies founded two basic principles energy efficiency environmental responsibility energy efficiency attempts serve dual purpose first geopolitical end dependency fossil fuel supplies countries second reduce energy consumption various methods assessing environmental impact residential buildings available number certifications created certifications actually help home owners users rather endorsing buildings constructed attempt sustainability thus making diffusion sustainability criteria construction much difficult study aims develop simple user friendly tool home owners provides rigor current sustainability certificates offer professional builder property developer sustainability appraisal carried based social environmental economic impacts evaluated using easily understandable parameters integrated system verified case study real residential building subsequent results demonstrate better building performance pursuing green demand housing also indicate changes required improvement applying new integrated tool able confirm ease use along highly comparable results evaluation tools currently available elsevier rights reserved
paper presents novel relational database architecture aimed visual objects classification retrieval based content images methods search classify images based content use algorithms generating comparing keypoint descriptors present new method quickly compare visual features based fuzzy sets embedded real database environment also present full framework extension microsoft sql server database allows search classify images directly sql query command large data sets visual objects system utilizes standard indexing mechanisms sql queries tested method state art dataset
purpose fatigue common end stage renal disease patients receiving hemodialysis reduces significantly quality life associated cause cardiac related mortality unfortunately little known course fatigue patients chronic hemodialysis methods vitality subscale short form health survey administered patients january june november results score differ significantly among similarly year course vitality subscale score differ significantly among stratification patients sex age bmi iadl charlson patients changed fatigue status fatigued patients became fatigued fatigued patients became fatigued patients changed fatigue status fatigued patients became fatigued fatigued patients became fatigued patients changed fatigue status fatigued patients became fatigued fatigued became fatigued conclusion present study first identify variations fatigue status among patients chronic hemodialysis year course findings suggest frequently assess presence severity fatigue patients chronic hemodialysis
construction companies well companies operating real estate market facing number challenges internal external environments time industry presents several options objective study identify construction sector management problems exploring real estate market construction industry latvia comparing situation baltic states study approaches also macroeconomic problems number related issues may useful management companies construction industry real estate market comparative statistical data processing analysis well historical methods used study real estate market cyclical development real estate market affects real estate price fluctuations construction cost price fluctuations changes economic situation general thus creating number challenges market development investment decision making necessary pay close attention construction industry real estate market research
decades known diagnostic statistical manual mental disorders dsm diagnosis antisocial personality disorder aspd nonadequate operationalization psychopathy crego widiger dsm alternative model personality disorders provides opportunity rectify long held concerns current study compared section iii alternative model trait based conception aspd categorical model main diagnostic codes section dsm terms associations differing models psychopathy also evaluated validity trait based conception broadly relation measures antisocial tendencies well psychopathy participants male inmates administered battery self report interview based researcher rating measures relevant constructs analyses showed section iii aspd outperformed section aspd predicting scores hare psychopathy checklist revised pcl additionally aggregate scores section iii aspd performed well capturing variance differing aspd psychopathy measures finally found section iii aspd impairment criteria added incrementally section iii aspd traits predicting pcl psychopathy scid aspd
splanchnic vein thrombosis svt encompasses budd chiari syndrome bcs extrahepatic portal vein obstruction ehpvo mesenteric vein thrombosis philadelphia negative myeloproliferative neoplasms mpns leading systemic cause non cirrhotic non malignant svt diagnosed bcs patients one third ehpvo patients svt patients molecular marker jak detectable overt mpn without latter mpn molecular markers mutations jak exon calr mpl genes extremely rare immediate anticoagulation heparin used treat acute patients upon clinical deterioration catheter directed thrombolysis trans jugular intrahepatic portosystemic shunt used conjunction anticoagulation orthotopic liver transplantation reliable option bcs patients lack response treatments without contraindication due mpn long term oral anticoagulation vitamin antagonists vka recommended svt patients mpn related permanent prothrombotic state benefits adding aspirin vka uncertain cytoreduction warranted svt patients overt mpn appropriateness doubtful molecular mpn without hypercythaemia
purpose case probable interaction levothyroxine ritonavir presented along review relevant literature recommendations clinical management summary year old woman human immunodeficiency virus infection recently undergone thyroidectomy benign multinodular goiter presented clinic hypothyroidism also found pregnant treatment levothyroxine daily initiated receiving antiretroviral therapy abacavir lamivudine lopinavir ritonavir pregnancy patient persistently elevated serum thyroid stimulating hormone tsh concentrations despite gradual escalation levothyroxine dosage daily interaction ritonavir levothyroxine suspected dolutegravir substituted lopinavir ritonavir within months tsh concentration normalized daily levothyroxine dose tapered month period stabilized tsh concentrations remained within normal range month follow period scoring case using drug interaction probability scale yielded score indicating probable interaction levothyroxine ritonavir literature search identified reported cases interactions involving levothyroxine ritonavir conclusion potentially serious underrecognized drug interaction ritonavir levothyroxine observed pregnant woman postthyroidectomy related hypothyroidism case review cases reported literature indicate higher usual doses levothyroxine may required patients taking ritonavir concurrently
data conversion become emerging topic bigdata era face challenge rapid data growth legacy existing relational databases need convert nosql column family database order achieve better scalability conversion sql nosql databases requires combining small normalized sql data tables larger nosql data tables process called denormalization challenging issues data conversion group denormalized columns large data table families order ensure performance query processing paper propose efficient heuristic algorithm gpa graph based partition algorithm address problem use tpc tpc benchmarks demonstrate column families produced gpa efficient large scale data processing
spite many observational experimental studies relations television violence found literature still agreement eventual causal relationship even authors observed positive correlation variables necessarily causal might depend third factor although results show eventual short term causal effects mass media violent behavior ones suggest opposite direction effect third group suggest rather bidirectional influences finally authors talk cathartic effects violent programs final part article suggests possible psychological models explanation eventual relationship variables
migraine highly prevalent headache disorder especially women brain derived neurotrophic factor bdnf receptor tropomyosin receptor kinases trkb well extracellular signal regulated kinase erk downstream target amp responsive element binding protein creb strongly associated transmission nociceptive information however involvement substances migraine rarely examined present study intraperitoneal injection nitroglycerin ntc successfully induced rat migraine attack evidenced behavioral testing location abundance substances migraine model determined immunohistochemistry real time polymerase chain reaction pcr western blot enzyme linked immunosorbant assays elisa results showed bdnf trkb phosphor erk creb regulated brain neurons male female rats ntg induced migraine compared non migraine control whereas expression levels decreased headache free intervals migraine compared migraine attacks estrogen important contributor migraine female ovariectomized rats showed significant reduction expression bdnf trkb creb erk attacks intervals ntg induced migraine relative rats ovaries intraperitoneal administration exogenous estrogen recovered expression ovariectomized rats collectively study unveiled positive correlation bdnf trkb erk creb axes ntg induced migraine promoting effects estrogen signals migraine findings contribute understanding pathogenesis migraine molecular basis
tumor necrosis factor alpha tnf alpha blockers popular therapeutic choice number inflammatory diseases thus far five tnf alpha blockers approved clinical use etanercept infliximab adalimumab golimumab certolizumab despite considered relatively safe serious side effects associated immune suppression reported including central peripheral nervous system cns demyelinating disorders still elusive whether events mere coincidence side effect anti tnf alpha use paper review published case reports cns demyelination associated anti tnf alpha therapy present follow previously reported patients developed neurologic symptoms suggestive cns demyelination received anti tnf alpha treatment also discuss possible role tnf alpha blockers demyelination
paper slew rate enhancement method using extra paths recycling folded cascode rfc amplifier presented added transistors cut region small signal operation automatically turned slewing phase therefore negative positive slew rates improved without increasing power dissipation small signal operation simulation results cmos technology show times enhancement average slew rate reduction settling time without affecting gain bandwidth power dissipation compared conventional rfc structure
software fault prediction important software engineering field fault prediction helps engineers manage efforts identifying complex parts software errors concentrate researchers usually study fault proneness modules modules zero faults minority faults system study present methods models prediction fault count fault fix cost fault fix effort compare effectiveness different prediction models research proposes using set procedural metrics predict three fault measures fault count fix cost fix effort five regression models used predict three fault measures study reports three data sets published nasa models fault evaluated using root mean square error comparison amongst fault measures conducted using relative absolute error models show promising results provide practical guide help software engineers allocating resources software testing maintenance cost fix models show equal better performance fault count effort models
qualitative values address personal interpersonal dimensions often overlooked research examines mental well among young patients anorexia nervosa aim review identify describe factors promote impede relationships nurses children adolescents young adults diagnosed anorexia nervosa also explore describe relationships benefit patients processes toward increased health well descriptive literature synthesis conducted following four steps described evans three databases cinahl psycinfo pubmed used search qualitative articles fourteen articles met criteria inclusion analysed key findings identified categories themes formulated compared across studies four themes presented results essentials relationship person centre nurses attitudes knowledge addition contribution knowledge anorexia manifested findings demonstrate necessity nurses person centred relationships patients attitudes characterised presence genuine commitment motivation nurses likely convey sense trust safety communicate openness honesty review suggests motivation patients adhere treatment likely increase nurses approach patients characteristics attitudes argue findings relevant nurses everyday practices
previous animal studies indicated associations circadian clock genes cognitive impairment study assessed whether circadian clock genes associated cognitive aging independently complex interactions old taiwanese population also analyzed interactions environmental factors genes influencing cognitive aging total taiwanese subjects aged years taiwan biobank analyzed mini mental state examinations mmse administered subjects mmse scores used evaluate cognitive function data showed associations cognitive aging single nucleotide polymorphisms snps key circadian clock genes clock npas rora rorb also found interactions clock npas rora rorb affected cognitive aging finally investigated influence interactions clock rora rorb environmental factors alcohol consumption smoking status physical activity social support cognitive aging similar study indicates circadian clock genes clock npas rora rorb genes may contribute risk cognitive aging independently well gene gene gene environment interactions
candida albicans major fungus colonises medical implants causing device associated infections high mortality antagonistic bacterial products interesting biological properties biosurfactants recently considered biofilm prevention study investigated activity lipopeptide biosurfactant produced bacillus subtilis adhesion biofilm formation albicans medical grade silicone elastomeric disks seds chemical analysis stability surface activities crude extract physicochemical characterisation coated silicone disk surfaces also carried showed good reduction water surface tension low critical micelle concentration good emulsification activity thermal resistance stability incubation significantly reduced adhesion biofilm formation three albicans strains seds range respectively pre coated seds fungal adhesion biofilm formation reduced respectively additionally inhibit viability albicans strains planktonic sessile form chemical analysis crude extract revealed presence two families lipopeptides principally surfactin lower percentage fengycin evaluation surface wettability indicated coating seds surface successful although uneven significantly prohibits initial deposition albicans slows biofilm growth suggesting potential role biosurfactant coatings preventing fungal infection associated silicone medical devices
present theoretical study electronic thermal transport polycrystalline heterostructures combining graphene hexagonal boron nitride hbn grains varying size distribution increasing hbn grain density percent system evolves good conductor insulator mobility dropping orders magnitude sheet resistance reaching omega regime seebeck coefficient suppressed mixing thermal conductivity polycrystalline hbn found order results agreeing available experimental data provide guidelines tuning hbn properties context two dimensional materials engineering particular proved electrical thermal properties largely affected morphological features grain size composition find cases nanometer sized polycrystalline hbn heterostructures good thermoelectric materials
study investigated perspective international patients individual symptoms atopic dermatitis eczema determining treatment response questionnaire developed evaluate importance symptoms patient perspective patients asked important features deciding whether treatment working rated symptoms point likert scale patients approached via harmonising outcome measures eczema home collaborators self selected take part line survey patients countries completed survey parents children eczema ten items rated quite important important respondents itch pain soreness skin feels hot inflamed bleeding involvement visible sensitive body sites cracks sleep difficulties amount body affected weeping oozing results may use determining face validity scales cross cultural patients perspective
pneumonia generates considerable negative impacts elderly despite widespread uses vaccines appropriate antibiotics morbidity mortality elderly pneumonia significantly higher compared counterparts young populations definitive mechanisms high vulnerability elderly pathogen threats unclear age associated chronic low grade inflammation augments susceptibility severity pneumonia elderly cellular senescence one hallmarks aging characteristics cell growth arrest senescence associated secretory phenotype sasp properties beneficial sequence senescence clearance regeneration transient manner however persisting senescent cell accumulation excessive sasp might induce sustained low grade inflammation disruption normal tissue microenvironments aged tissue emerging evidence indicates cellular senescence key component pathogenesis chronic obstructive pulmonary disease copd idiopathic pulmonary fibrosis ipf known age related increase risk pneumonia addition structural collapses copd ipf might increase vulnerability pathogen insults sasp discuss current advances understanding impacts cellular senescence elderly pneumonia chronic lung disorders heighten risk respiratory infections
recently new methodology developed automated fatigue crack growth fcg life analysis components based finite element stress models weight function stress intensity factor solutions algorithms define idealized fracture geometry models paper describes new methodology used integrate fcg analysis highly automated design assessments component life reliability one application fcg model automation supporting automated calculation fracture risk due inherent material anomalies occur anywhere volume component automated schemes developed divide component computationally optimum number sub volumes similar life risk values determine total component reliability accurately efficiently another application fcg model automation supporting integration fcg life calculations manufacturing process simulation perform integrated computational materials engineering calculation full field location specific residual stresses microstructure linked directly automated life analysis determine impact manufacturing parameters component reliability
paper presents three new contributions power flow analysis unbalanced three phase distribution systems first complex vector based model alpha beta stationary reference frame developed state power flow equations using compact matrix formulation proposed model based kirchhoff current law kcl kirchhoff voltage law kvl general exact power transformer model alpha beta reference frame proposed finally transformer model incorporated power flow problem shown use orthogonal reference frame simplifies modeling distribution network components work network power transformer well type loads type generators slack bus modeled using node incidence matrix instead admittance matrix information grid topology grid parameters including power transformers separately organized demonstrated proposed formulation ready incorporate complex models loads generators storage devices model tested using ieee node ieee node test feeders different transformer connections balanced unbalanced lines loads
paper proposes spiral shaped dispersive delay structure spiral dds composed vertically stacked spiral coils vertical vias pass network architecture produce large group delay peak certain frequency ghz range basic performance spiral dds studied theoretically group delay successfully generated compact multilayered architecture dimensions paper also reports losses occurred dds comes conductor loss dielectric loss
economics establishing perennial species renewable energy feedstocks widely investigated climate change adapted diversification option landholders primarily using net present value npv analysis npv account key uncertainties likely influence relevant landholder decision making real options analysis roa alternative method accounts uncertainty future conditions large upfront irreversible investment involved establishing perennials limited applications roa evaluating land use change decision economics even fewer applications considering climate change risks influence spatially varying climate risk biomass conversion economic widely evaluated using npv methods effects spatial variability climate land use change scarcely assessed roa study applied simulation based roa model evaluate landholder decision convert land agriculture biomass spatially explicit model considers price yield risks baseline climate two climate change scenarios geographically diverse farming region found underlying variability primary productivity across study area substantial effect conversion thresholds required trigger land use change compared results npv analysis areas traditionally thought quite similar average productive capacity display large differences response inclusion production price risks effects climate change broadly reduced returns required land use change biomass low medium rainfall zones increased higher rainfall areas additionally risks posed climate change exacerbate tendency npv methods underestimate true conversion thresholds results show even severe drying warming crop yield variability affected perennial biomass plantings comparatively little study area economically viable conversion biomass prices exceed significant areas become profitable biomass plantings conclude biomass become valuable diversification option synchronisation products services derived biomass development markets vital elsevier ltd rights reserved
background multi centre randomized controlled trial rct compared modified mentalisation based treatment mbt specialist supportive clinical management sscm patients eating disorders eds borderline personality disorder symptoms bpd group patients presents complex challenges clinical services treatment addresses multiple problems potential improve outcome mbt shown effective improving outcome patients bpd use reported methods sixty eight eligible participants randomised mbt sscm primary outcome measure global score eating disorder examination secondary outcomes included measures bpd symptoms zanarini rating scale borderline personality disorder general psychiatric state quality life service utilisation participants assessed baseline months randomisation analysis performed using linear mixed models results participants completed month follow early drop occurred significantly sscm group drop vary treatment model later therapy sometimes attributed participants moving away higher drop amongst smokers higher neuroticism scores participants mbt arm sscm arm attended least therapy sessions offered amongst remaining trial months mbt associated greater reduction shape concern weight concern eating disorder examination compared sscm months decline bpd symptoms groups combined ten participants reported adverse events trial mostly self harm one death attributed unexplained coroner conclusions high drop rate made interpretation results difficult greater involvement research staff clinical management might improved compliance therapy research assessment mbt may impact core body image psychopathology
previous studies shown relationship uric acid concentration progression renal disease studied causality serum uric acid concentration progression diabetic nephropathy individuals type diabetes finndiane study renal status assessed urinary albumin excretion rate estimated glomerular filtration rate egfr baseline end follow based previous genomewide association studies serum uric acid concentration single nucleotide polymorphisms snps good imputation quality selected snp score score used assess causality serum uric acid renal complications using mendelian randomization approach baseline serum uric acid concentration higher worsening renal status multivariable cox regression analyses baseline serum uric acid concentration independently associated progression diabetic nephropathy mean follow years however period baseline serum uric acid independently associated decline egfr cross sectional logistic regression analyses snp score associated serum uric acid concentration nevertheless mendelian randomization showed causality uric acid diabetic nephropathy egfr categories egfr continuous variable thus results suggest serum uric acid concentration causally related diabetic nephropathy downstream marker kidney damage
young adolescents generally considered self absorbed studies indicate lack relevant general cognitive abilities impulse control mature early adulthood however idealism may cause intolerant unfair treatment others thus result engaging altruistic behavior present study aimed clarify whether young adolescents altruistic adults thus indicate whether altruistic competence domain specific one hundred young adolescents adults participated face face two round third party punishment experiment interaction group participant served allocator could share money units stranger another participant knew allocator could punish acquaintance stranger participants reported emotions first round end experiment participants justified behavior round results indicated young adolescents shared punished adults sharing associated reference fairness justifications altruistic punishment associated subsequent positive emotion sum greater altruism young adolescents compared adults mature cognitive abilities provides evidence domain specificity altruistic competence moreover sharing altruistic punishment related specific cognitive emotional mechanisms respectively
creating new model train high quality primary care workforce great interest american health care stakeholders consensus effective educational approaches need combined rewarding work environment emphasize good work life balance focus achieving meaningful outcomes center patients public still significant barriers limit numbers clinicians interested pursuing careers primary care including low earning potential heavy medical school debt lack respect physician colleagues enormous burdens record keeping enlarge energize pool primary care trainees look especially changes focus institutions practice environment students residents need training environments primary care clinicians interdisciplinary teams play crucially important role patient care variety reasons many academic medical centers easily meet standards authors propose major part primary care education training located settings high performing health systems built comprehensive integrated care models primary care clinicians play principle role leadership care delivery
background study investigates relationship insomnia cognitive dysfunctions including subjective memory impairment smi mild cognitive impairment mci dementia considering depression community sample elderly individuals methods data elderly individuals aged years obtained nationwide dementia epidemiological study conducted south korea cognitive functional status assessed mini mental state examination consortium establish registry alzheimer disease assessment packet clinical assessment battery insomnia defined presence least one four sleep complaints difficulty initiating sleep difficulty maintaining sleep early morning awakening nonrestorative sleep accompanied moderate severe daytime consequences depression evaluated using geriatric depression scale results prevalence insomnia patients smi mci dementia found respectively patients smi mci dementia significantly likely insomnia four sleep complaints normal comparison patients adjusting sociodemographic factors significant relationships cognitive dysfunctional status insomnia remained however adjusting sociodemographic factors depression significant relationships sleep complaints insomnia remained conclusion insomnia common complaint elderly smi mci dementia depression might play important factor relationship insomnia cognitive dysfunctional status elderly
fully electric vehicles multiple drivetrains allow significant variation steady state transient cornering responses individual control electric motor drives consequence alternative driving modes created provide driver option select preferred dynamic vehicle behavior article presents torque vectoring control structure based combination feedforward feedback contributions continuous control vehicle yaw rate controller specifically developed easily implementable real world vehicles novel model based procedure definition control objectives described detail together automated tuning process algorithm implemented control functions demonstrated experimental vehicle tests results show possibilities torque vectoring control designing vehicle understeer characteristic authors published elsevier ltd
background aimscontingency management one effective behavioral interventions promote drug abstinence availability treatment limited evaluated efficacy acceptability internet based relative internet based monitoring goal setting control group nationwide sample cigarette smokers designrandomized controlled trial month follow ups settingunited states participantssmokers states enrolled mean age female intervention comparatorparticipants randomized earn financial incentives weeks based video verified abstinence using breath carbon monoxide output abstinent contingent group based submitting samples submission contingent groups also received based goals deposit required groups could recouped initial earnings measuresthe primary outcome point prevalence week secondary outcomes point prevalence month follow ups percentages negative samples adherence sampling protocol treatment acceptability ratings visual analog scale findingsabstinence rates differed weeks groups odds ratio confidence interval month follow ups two main treatment phases significant differences negative cos adherence submission protocol equivalent difference lowest acceptability ratings items assessing deposit whereas highest ratings concerned ease intervention graph results earning money conclusionsa contingency management financial incentive program delivered via internet improved short term abstinence rates compared internet program without incentives
multi view facial expression recognition challenging active research area computer vision paper propose simple yet effective method called locality constrained linear coding based layer llcbl model learn discriminative representation multi view facial expression recognition address issue large pose variations locality constrained linear coding adopted construct overall bag features model used extract overall features well estimate poses first layer second layer establish one specific view dependent model view respectively pose information facial image known use corresponding view dependent model second layer extract features combining features two layers obtain unified representation image evaluate proposed approach conduct extensive experiments dfe multi pie databases experimental results show approach outperforms state art methods elsevier rights reserved
increasing studies demonstrated interferon gamma ifn gamma serves critical inflammatory cytokine essential induce immunosuppressive effects mesenchymal stem cells mscs however mechanisms underlying enhanced immunosuppressive effects ifn gamma stimulated mscs gamma mscs fully understood msc derived microvesicles msc mvs viewed potential pivotal mediators immunosuppressive effects mscs moreover micrornas mirnas important regulators immunological processes shuttled cell cell mvs aim study analyze mirna expression signature mvs derived gamma mscs gamma msc mvs may provide better understanding immunosuppressive property parent cells mirna microarray bioinformatics analysis found significantly differentially expressed mirnas dems gamma msc mvs compared msc mvs potential target genes signaling pathways regulated dems predicted analyzed interestingly many dems predicted signaling pathways demonstrated involved immunoregulation furthermore network immunoregulation related pathways relevant dems constructed collectively research mirna repertoires gamma msc mvs provides new perspectives mechanisms underlying enhanced immunosuppressive property gamma mscs also paves way clinical application potent organelles future
well known reweighted zero attracting least mean square algorithm rza lms effective estimation sparse system channels however rza lms algorithm utilizes fixed step size balance steady state mean square error convergence speed resulting reduction performance thus trade convergence rate steady state mean square error must made paper utilizing nonlinear relationship step size power noise free prior error variable step size strategy based error function proposed simulation results indicate proposed variable step size algorithm shows better performance conventional rza lms sparse non sparse systems
background myocardial tolerance ischemia influenced age preoperative cyanosis unknown mechanisms significantly affects postoperative outcomes cytochrome oxidase ccox terminal enzyme mitochondrial electron transport chain may play role susceptibility ischemic reperfusion injury study aimed investigating changes human myocardial ccox activity based age preoperative oxygen saturation understand role transition neonatal mature myocardium hypoxic conditions methods right atrial appendage patients undergoing first time surgical repair palliation congenital heart defects analyzed steady state ccox activity oxidation ferrocytochrome via spectrophotometry steady state ccox subunit protein content protein immunoblotting student test compared ccox activity protein levels patients preoperative hypoxia normoxia multiple linear regression analysis used assess effects age preoperative arterial oxygen saturations sao ccox protein activity protein content results thirty two patients median interquartile range age days preoperative oxygen saturation enrolled independent age preoperative sao associated significantly greater ccox steady state activity additionally older age associated increased ccox steady state activity combination preoperative sao age account variation ccox steady state activity increase ccox subunit protein content either age preoperative hypoxia conclusions patients congenital heart disease increase ccox steady state activity seen increasing age hypoxia leads upregulation ccox steady state activity without increase amount enzyme protein higher ccox activity older cyanotic patients may indicate ccox dependent reactive oxygen species mechanism injury
complex traffic networks include number controlled intersections commonly multiple districts municipalities result overall traffic control problem extremely complex computationally moreover given different municipalities may distinct non aligned interests traffic light controller design inherently decentralized consideration almost entirely absent related literature complexity decentralization great bearing quality traffic network overall well security consider issues dynamic traffic network first propose effective local search algorithm efficiently design system wide control logic collection intersections second propose game theoretic stackelberg game model traffic network security attacker deploy denial service attacks sensors develop resilient control algorithm mitigate threats finally propose game theoretic model decentralization investigate model context baseline traffic network design well resilient design accounting attacks methods implemented evaluated using simple traffic network scenario sumo
background phase data suggested guselkumab anti interleukin monoclonal antibody efficacious psoriasis objective sought assess efficacy safety guselkumab moderate severe psoriasis versus placebo adalimumab including interrupted treatment switching adalimumab nonresponders guselkumab methods patients randomized guselkumab weeks every weeks placebo guselkumab weeks guselkumab weeks adalimumab week week every weeks week week guselkumab greater improvement psoriasis area severity index pasi score baseline pasi responders rerandomized guselkumab placebo guselkumab loss response placebo guselkumab responders adalimumab responders received placebo guselkumab loss response nonresponders received guselkumab results week patients receiving guselkumab achieved investigator global assessment iga score cleared minimal pasi versus placebo coprimary end points guselkumab superior adalimumab week iga score greater improvement pasi score baseline pasi week iga score pasi improvement pasi score baseline weeks better persistence response observed guselkumab maintenance versus withdrawal groups adalimumab nonresponders switched guselkumab achieved pasi week guselkumab improved patient reported outcomes adverse events comparable among groups limitations one year follow limits retreatment data conclusions guselkumab highly effective well tolerated maintenance therapy including adalimumab nonresponders
computer network dynamic entity whose state changes introduction new services installation new network operating system addition new hardware components creation new user roles attacks various actors instigated aggressors unauthorized intrusion computer system network one serious threats computer security intrusion detection systems developed provide early warning intrusion defensive action taken prevent minimize damage intrusion detection involves detecting unusual patterns activity patterns activity known correlate intrusions one two publicized threats security intruder viruses often referred hacker cracker various security mechanisms employed network give complete picture security complete network paper derived number probabilities prediction rules implemented probabilities simulation model web application protect datacenter
although transportation established facilitator barrier health self management little known context transportation shapes health self management behaviors decision making among older adults chronic conditions study interviewed older adults chronic conditions florida examine perspectives transportation influences chronic care self management data systematically analyzed themes thematic findings revealed transportation intersected participants everyday experiences chronic health self management evaluated transportation part process making decisions health creative problem solving transportation became additional health self management activity addressing complex needs findings suggest context transportation goes beyond basic facilitator barrier health enhance understanding transportation services policies may changed better address needs older adults chronic conditions
postoperatory atrial fibrillation common complication cardiac surgery among others cardiac structural changes epicardial adiposity inflammation could associated increased cardiovascular risk including enough studies association epicardial fat inflammation paper assesses association structural changes human right atrial appendages raa patients without focus inflammation raa specimens coronary patients ages years divided groups including patients without postoperatory histological immunohistochemical imh morphometrical methods used assessing myocardial fatty infiltration epicardial inflammatory foci cardiomyocytes size vacuolation extent interstitial fibrosis atrial changes found patients groups higher proportions postoperatory patients extent myocardial fatty infiltration twofold threefold higher patients postoperatory associated epicardial mononuclear inflammation raa structural changes indicate susceptibility develop postoperatory currently inflammation recently emerged new independent risk factors proposed study raa structural changes including epicardial inflammatory foci relation postoperatory frequency
paper presents domain decomposition type method solving real symmetric hermitian eigenvalue problems seek eigenpairs interval alpha beta eigenpairs next given real shift zeta newton based scheme described whereby problem converted one deals interface nodes computational domain approach relies fact inner solves related local subdomain relatively inexpensive newton scheme exploits spectral schur complements lead called eigenbranches rational functions whose roots eigenvalues original matrix theoretical practical aspects domain decomposition techniques computing eigenvalues eigenvectors discussed parallel implementation presented performance distributed computing environments illustrated means numerical examples
headache frequent neurological symptom children adolescents recurrent headaches significant disabling effect consequences including school absenteeism decreased participation extracurricular activities poor academic performance risk factor chronic headaches pain syndromes merit increased attention common types primary headache children adolescents migraine tension type headache tth recent survey south korean school students schoolchildren reported recurrent headaches tth frequent recurrent migraine headaches frequency migraine tth increased age prevalence rate tth urban areas higher suburban rural areas trend found severe disabilities occur older children headache children adolescents migraine severe headache related disabilities predictors headache related disability found migraine severe intensity headache frequent headache longer duration symptoms presentation children adolescents recurrent significant headaches diagnosed treated promptly reduce headache related disability improve quality life
paper presents new approximated integer delayed modeling control technique continuous time fractional delay differential equations cfddes using impulse response sequences cfdde balanced model reduction method delay free discrete time state space model constructed equivalent discrete time integer delay difference equation didde obtained transforming obtained discrete time state space model controller type block companion form furthermore based obtained didde equivalent continuous time integer delay differential equation cidde determined means newly developed chebyshev bilinear approximation method digital control cfdde optimal discrete time integer delayed control law didcl designed using conventional discrete time lqr approach together obtained delay free discrete time state space model hand continuous time control cfdde continuous time integer delayed control law cidcl determined designed didcl means inverse chebyshev bilinear approximation method finally digital analog integer delayed observers constructed implementations developed didcl cidcl respectively illustrative example given demonstrate effectiveness proposed method elsevier inc rights reserved
task interdependence received great deal attention critical driver project dynamics study focuses one key dynamics helping among information technology implementation project team members uniquely distinguish perceptions receiving help one personally provides team members positive inequity giving one receives negative inequity argue using equity theory frame members tendency resolve perceived inequity adjusting subsequent levels helping extent adjustment moderated task interdependence results empirical evaluation members implementation teams examined several points throughout project cycles provide insight relationships extending bounding equity theory find lower interdependence augments effect positive inequity subsequent helping leaves effect negative inequity unaffected find support inverted shaped relationship level subsequent helping team final cost implementation holds critical implications project team design ensuing dynamics
vocal tract resonances provide reliable information speaker body size human listeners use biosocial judgements well speech recognition although humans accurately assess men relative body size voice alone ability acquired remains unknown study test prediction accurate voice based size estimation possible without prior audiovisual experience linking low frequencies large bodies ninety one healthy congenitally early blind late blind sighted adults aged participated study basis vowel sounds alone participants assessed relative body sizes male pairs varying heights accuracy voice based body size assessments significantly exceeded chance differ among participants sighted congenitally blind lost sight later life accuracy increased significantly relative differences physical height men suggesting blind sighted participants used reliable vocal cues size vocal tract resonances findings demonstrate prior visual experience necessary accurate body size estimation capacity integral nonverbal communication speech perception may present birth may generalize broader cross modal correspondences
grid electricity generation using renewable energy technologies become reliable source fulfill needs rural areas limited level without considering conventional resources main purpose study propose economical optimized design electricity generation using hybrid energy source biomass agricultural farm residential community centered small village district layyah punjab province pakistan electric load data collected irrigation residential needs hybrid optimization model electric renewable homer used design perform techno economic analysis meet load requirements using biomass hybrid configuration solar irradiance data available biomass potential farm used homer software perform analysis total net present cost npc cost electricity coe obtained solution homer analysis results refined performing sensitivity analysis sensitivity parameter biomass potential biomass price solar irradiance variations loads used sensitivity analysis analysis compares performance system shows system techno economically viable based net present cost cost energy elsevier ltd rights reserved
objective limited data exist child abuse related immune variation pregnancy despite implications maternal infant health extensive data showing abuse history depression related increased inflammation populations study examined associations among child abuse depression circulating levels inflammatory markers perinatal health pregnant adolescents group high risk childhood abuse poor birth outcomes methods pregnant teenagers years latina reported abuse depression two blood draws gestational weeks second third trimesters respectively interleukin reactive protein birth outcomes collected results abuse depression interacted predict higher second trimester severely abused adolescents high depression higher relative severely abused adolescents low depression depression differentiate levels low abuse severity abuse also interacted predict gestational age birth low abuse high high abuse low infants earlier gestational age birth cortisol second trimester mediated association gestational age birth indirect effect estimate conclusions depression severity distinguished levels among severely abused pregnant latina adolescents unrelated among less severely abused adolescents cortisol explained relationship earlier gestational age birth multiple adversities inflammation may influence birth outcomes potentially affect intergenerational health
objective postmenopausal women exhibit elevated brachial ankle pulse wave velocity bapwv indicator arterial stiffness associated increased risk cardiovascular events mortality purpose study examine impact combined resistance aerobic exercise training bapwv blood pressure cardiovascular fitness postmenopausal women stage hypertension methods twenty postmenopausal women age systolic diastolic randomly assigned exercise con combined exercise group group performed resistance aerobic exercise weeks times per week exercise intensity increased gradually heart rate reserve every weeks bapwv blood nitrite nitrate endothelin cardiovascular fitness body composition measured week intervention results bapwv mmol nitrite nitrate functional capacity body composition significantly improved group weeks training changes observed con group conclusions findings indicate weeks combined exercise training improves arterial stiffness blood nitrite nitrate functional capacity body composition postmenopausal women stage hypertension thus study provides evidence combined exercise training useful therapeutic method improve cardiovascular health reduce cardiovascular disease risk postmenopausal women hypertension
study investigated relationship self reported time bed sleep quality association self reported internalizing externalizing symptoms sample elementary school students female recruited rural midwestern elementary school path models used estimate proposed associations controlling grade level gender curvilinear associations found time bed anxiety depressive symptoms irritability marginal curvilinear trends found time bed emotion dysregulation reactive aggression proactive aggression sleep quality negatively associated anxiety depressive symptoms irritability reactive aggression delinquency engagement gender grade differences found across models findings suggest examining self reported time bed linear quadratic sleep quality important understanding internalizing externalizing symptoms associated sleep school age youth incorporating self reported sleep assessments clinical practice school based evaluations may implications child adjustment
objective different biomaterials used scaffolds bone tissue engineering purpose study analyze effect bovine bone collagen porosity water retention degradation rate biomechanical characteristics composite scaffolds methods bovine bone collagen solution mixed cellulose nanofibers solution mixture added certain quality hydroxyapatite divided mixture two groups according different bovine bone collagen solution mass fraction bovine bone collagen bovine bone collagen surface structure pore size observed scanning electron microscopic calculated porosity degradation rate water content biomechanical properties results two groups scaffold materials showed multi pore structure average pore size porosity statistical analysis showed two groups material porosity difference statistically significant degradation rates two groups scaffold materials six weeks statistical analysis showed degradation rate material differences two groups statistically significant water content two groups scaffold materials perpendicular perpendicular statistical analysis showed water content material differences two groups statistically significant biomechanical properties second group increased significantly conclusion could seen experimental data bovine bone collagen could increase pore size improved stability degradation biomechanical strength materials therefore biocomposite studied several characteristics considered ideal use scaffold osteoconduction osteoinduction
purpose purpose paper develop compare conventional neural network based controllers gas turbines design methodology approach design two different controllers considered controllers consist narma artificial neural network based nonlinear autoregressive moving average narma controller feedback linearization conventional proportional integrator derivative pid controller low power aero gas turbine briefly described parameters adjusted tuned simulink matlab environment according requirement gas turbine system control objectives purpose simulink neural network based modelling used performances controllers explored compared base design criteria performance indices findings shown narma neural network based controller superior performance pid controller practical implications study aims using artificial intelligence gas turbine control systems originality value paper provides novel methodology control gas turbines
investigated racial content perceivers mental images different socioeconomic categories selected participants either high low prejudice toward poor participants saw pairs visually noisy face images depending condition participants chose face looked like poor person middle income person rich person averaged faces selected create composite images social class second group participants rated stereotypical blackness images also rated face images variety psychological traits participants high economic prejudice produced strongly class differentiated mental images imagined poor blacker middle income wealthy people also imagined less positive psychological characteristics participants low economic prejudice also possessed images wealthy relatively white represented poor middle class people less racially differentiated way discuss implications understanding intersections race class social perception
health monitoring civil engineering structures paramount importance subjected natural hazards extreme climatic events like earthquake strong wind gusts man made excitations traditional modal identification methods reliant stationarity assumption vibration response posed difficulty analyzing nonstationary vibration earthquake human induced vibration recently tensor decomposition based methods emerged powerful yet generic blind without requiring knowledge input characteristics signal decomposition tool structural modal identification paper tensor decomposition based system identification method explored estimate modal parameters using nonstationary vibration generated due either earthquake pedestrian induced excitation structure effects lag parameters sensor densities tensor decomposition studied respect extent nonstationarity responses characterized stationary duration peak ground acceleration earthquake suite earthquakes used investigate performance proposed method wide variety ground motions utilizing complete partial measurements high rise building model apart earthquake human induced nonstationary vibration real life pedestrian bridge also used verify accuracy proposed method
paper proposes innovative method power consumption measurement microcontroller based systems provides high accuracy wide dynamic range current values makes particularly suitable applications characterized alternating low high power modes fast current variations demonstrate using amp based voltage feedback configuration possible use shunt resistor values higher usual obtain increased voltage drops without affecting microcontroller power supply voltage consequently possible directly use data acquisition board acquire shunt voltage eliminating common errors like offset gain due use additional intermediate amplification stage proposed scheme successfully used accurately characterize power consumption single sensor node wireless sensor network
overarching objective article describe swedish public knowledge hiv attitudes toward people living hiv period within framework objective article also directs special focus association knowledge hiv transmission attitudes toward people hiv positive study based results questionnaire sent stratified random sample eight occasions study population comprises swedish general public aged stratified basis respondents age five age groups comprising study respondents total individuals completed questionnaire eight surveys survey instrument relatively short comprises questions knowledge attitudes sexual behaviour relating hiv eight surveys show public knowledge hiv different transmission routes high increased time increase level knowledge hiv transmitted people however public knowledge infectiousness individuals receiving treatment hiv infection low public attitudes toward people hiv also undergone clear shift time toward increased tolerance decline level fear especially social situations despite residual suspicion stigmatisation seen public attitudes people hiv positive obvious questions link hiv sexuality changes modest time public knowledge hiv transmission routes increased attitudes toward people hiv positive generally become tolerant positive least relation different social situations fear becoming infected declined time remains stigma continues direct suspicion people living hiv ascribe negative characteristics behaviors based prejudice results show however public attitudes toward sex relationships clearly accepting today previously symbolic association hiv group tending become weaker
objective explore describe experiences perceptions falls risk falling fall related consequences individuals incomplete spinal cord injury sci still walking design qualitative interview study applying interpretive content analysis inductive approach setting specialized rehabilitation hospital subjects purposeful sample individuals men years old years post injury chronic incomplete traumatic sci walking time mobility needs methods individual semi structured face face interviews recorded condensed coded find themes subthemes results one overarching theme revealed falling challenges identity self image normal comprised two main themes walking incomplete sci involves minimizing fall risk fall related concerns without compromising identity normal walking incomplete sci implies willingness increase fall risk order maintain identity normal informants aware increased fall risk took precautions willingly exposed risky situations important self identity informants expressed conditional fall related concerns experienced concerns limiting activity participation conclusion ambulatory individuals incomplete sci considered falls part life however falls interfered informants identities self images normal healthy well functioning expressed dysfunctional concerns falling interventions target
minimal data exist regarding documentation therapy associated infertility risk fertility preservation options initial oncology consultation prior systemic therapy study investigated factors affecting documentation assessed effect implementation adolescent young adult aya program documentation rates retrospective review charts patients receiving gonadotoxic therapy undertaken documentation pre post implementation aya program change documentation rates assessed using univariate multiple logistic regression total charts reviewed univariate analysis documentation less likely patients metastatic disease tumor type received less intensive chemotherapy older children lacked aya program involvement discussion common males multivariable analysis children older age tumor type stage relationship lack aya involvement associated lower rates documentation following aya program implementation rates increased respectively effect aya program implementation documentation noticeable leukemia lymphoma breast groups implementing aya consultation service adult cancer institution positive effect rates documentation specific programming improve service delivery aya cancer patients fertility counseling integrated patients undergoing gonadotoxic therapy
current evidence mixed role progesterone metabolites perinatal mood anxiety disorders measured second third trimester progesterone prog allopregnanolone allo levels elisa postpartum depression ppd clinician interview dsm criteria pregnant women prior diagnosis mood disorder methods included multivariate logistic regression general linear mixed effect models found adjustment every additional allo resulted reduction risk developing ppd findings extend previous work connecting allo depression within pregnancy indicate relationship pregnancy allo ppd worth exploration larger sample elsevier ltd rights reserved
energy transparency concept makes program energy consumption visible hardware software different system layers transparency enable energy optimizations layer layers well help programmers operating systems make energy aware decisions article focus deeply embedded devices typically used internet things iot applications demonstrate enable energy transparency existing static resource analysis sra techniques new target agnostic profiling technique without hardware energy measurements novel mapping technique enables software energy consumption estimations higher level instruction set architecture isa namely llvm intermediate representation level therefore introduces energy transparency directly llvm optimizer apply energy estimation techniques comprehensive set benchmarks including single multithreaded embedded programs two commonly used concurrency patterns task farms pipelines using sra llvm results demonstrate high accuracy deviation range isa sra profiling technique captures actual energy consumption llvm level average error
algarve region focus analysis place multiculturalism chosen many foreigners vacation end moving region portugal especially engage business easiness communication facilities returning home countries hours plane pointed main reasons settle algarve region according obtained indicators algarve migrant communities british dutch french european countries also community entrepreneurial women diaspora bet region another side issue migration still little explored academically however acknowledged presence british europeans algarve ecosystem long standing reality prior treaty constitution european union portugal signed analysis specifically concerns female migrants develop entrepreneurial activities region data revealed women middle upper middle class thus arises need reflect contribution boost economy development algarve used methodology consultation comparison demographic available well empirical contact key entities region looking back thematic collection intend relate gender roles strongly stigmatized man identity woman identity idea entrepreneurism assessing economic development needs country growing demand entrepreneurial activities considered woman role entrepreneur less explored various cultural social reasons potential waste
low temperature scr environmentally important reaction abatement nox stationary sources recent years femnox attracted significant attention potential catalyst process however catalytic activity resistance require improvement contribution femnox modified examine effect ceria catalytic activity resistance low temperature region preparation catalysts via citric acid method generate modified materials exhibit enhanced turnover compared femnox reduction adsorption tpd suitable ratio sites tpd chemisorbed surface oxygen xps beneficial promotion fast scr comparative resistance study femnox showed latter exhibited improved stability presence indicated retention pore volume adsorption surface composition xps situ drifts demonstrated chemisorbed containing species much stable presence compared femnox resulted formation significantly less metal sulphates nhhso crown copyright published elsevier rights reserved
human judgment often violates normative standards virtually judgment error received much attention conjunction fallacy judgment errors historically served evidence dual process theories reasoning insofar errors assumed arise reliance fast intuitive mental process corrected via effortful deliberative reasoning present research three experiments tested notion conjunction errors reduced effortful thought predictions based three different dual process theory perspectives tested lax monitoring override failure tripartite model results indicated participants higher numeracy less likely make conjunction errors association emerged participants engaged two sided reasoning opposed one sided reasoning confidence higher incorrect opposed correct judgments suggesting participants unaware errors
paper analyzes accuracy concerns self positioning unmanned ground vehicle undertaking simultaneous localization mapping environment information description provided vehicle sensor usually strong geometric feature thus paper puts forward method geometric feature simultaneous localization mapping environment description analyzing uncertainties type environment description paper uses computational geometry model describe uncertainties caused measuring error sensor last using computational geometry paper proposes location estimation algorithm helps reduce impact measuring errors calculation coordinates
knowledge material properties important machine design composite materials information found related literature standard therefore necessary determine measurements basic experiments mechanics materials paper presents new finite element model cell modeling material properties roving numerical modeling method one determine orthotropic macroscopic material properties roving model cell models numerically roving consists multiples thousands fibers embedded matrix material homogenized orthotropic material numerical results material properties roving applied definition macroscopic material properties fiber reinforced composite laminates
past decade rates depression suicide adolescents increasing collishaw journal child psychology psychiatry bor etal australian new zealand journal psychiatry time evidence rates diagnosis least referral depression adolescents declining libby etal archives general psychiatry john etal psychological medicine worrying statistics highlight importance disseminating accurate information risks benefits treatments adolescent depression order combat therapeutic nihilism extant controversy best ways treat adolescent depression particular regards use antidepressants may contributed trends specifically believe recent high profile publications incorrectly interpreted benefit risk ratio use antidepressants adolescent depression unfavourable cipriani etal lancet editorial review clinical trial pharmaco epidemiological data supports retention use antidepressants management depressed adolescents
background evaluating common complaint cough clinicians rely patient history physical guide also diverge guidelines screening testing lest certain diagnoses overlooked case presentation year old hispanic male presented pulmonologist office failing multiple courses antibiotics chronic cough six months duration described intermittent scant hemoptysis evanescent migratory non pruritic rash occasionally noted trunk limbs due financial concerns patient initially agreed limited testing eventually bronchoscopy pursued results pending patient presented emergency room worsening dyspnea blood tinged sputum weight loss diagnosis kaposi sarcoma lung confirmed histopathologic staining hiv aids confirmed hiv pcr copies count cells repeatedly denied hiv risk factors providers diagnosis established confirmed sexual promiscuity prior marriage greater years ago started haart initiating therapy due concern immune reconstitution syndrome worsening pulmonary status conclusion pulmonary kaposi sarcoma infrequent diagnosis yet risk significantly greater hiv infection diagnosis difficult symptoms radiographic findings nonspecific distinctly different appearance pulmonary opportunistic infections without treatment patients pulmonary median survival months chemotherapy haart may achieve relief symptoms improve survival following recommended screening guidelines furthering diagnostic evaluation persistently symptomatic patients key uncovering potentially fatal disease even patients whose symptoms may seem common benign irritating cough
extreme flood events often lead considerable loss human life previous studies stability criteria people floods account effect various slopes proposal appropriate stability criterion range slopes therefore important study mechanics based incipient velocity formula extended human body floodwater toppling instability ground slope included using laboratory flume experimental tests conducted obtain water depth velocity conditions toppling instability small scale model human body four slopes experimental data obtained flat ground slopes used determine values two parameters derived formula parameters unified corresponding mean values various slopes calculations using proposed formula unified parameters compare well scaled experimental data slope finally proposed formula used estimate critical velocities different depths typical adult differences stability criteria results obtained model prototype experiments also presented
spectral reflectance data including irradiance reflectance remote sensing reflectance colored dissolved organic matter cdom absorption coefficients cdom collected saginaw river kawkawlin river plume regions lake huron developed empirical band ratio algorithm derive cdom could directly applicable landsat imagery model ranking method used determine best band ratios well empirical functions one problem previous cdom estimations landsat imagery usually use rather real input data result study algorithms derived using performed much better using green red band ratio gave best accuracies fitting power exponential models power model rmse exponential model rmse power exponential models validated using independent data group achieving excellent results rmse respectively application exponential model cdom two landsat images demonstrated estimating cdom landsat imagery potential applications monitoring water quality long term large scale
study aims investigate pyrometallurgical reduction behavior tungsten trioxide ethanol temperature range thermodynamic analysis predicted single tungsten phase formation tungsten trioxide ethanol temperature range studied experiments carried flowing ethanol vol atmosphere tube furnace various reaction periods time extent reduction followed mass measurements xrd sem used carry phase morphological studies products obtained various stages reduction found temperature range oxide reduction incomplete owing sluggish reaction kinetics reactants higher temperatures tungsten trioxide reduction metallic tungsten complete within similar min similar min similar min respectively well facetted tungsten particles mean sizes observed conditions significant tungsten loss flowing gas stream via formation gaseous possible reaction pathways leading metallic tungsten discussed elsevier ltd rights reserved
purpose aim study compare salivary cortisol amylase levels psychological profiles patients burning mouth syndrome bms healthy subjects methods materials spitting method used collect unstimulated salivary salivary cortisol amylase levels determined using elisa caraway starch iodine technique slc questionnaire used determine psychological profiles results difference mean salivary cortisol levels patients bms healthy subjects significant difference mean amylase levels bms patients healthy subjects significant note patients case control groups psychological problems conclusion results showed higher salivary levels cortisol amylase patients bms compared healthy individuals psychological problem prevalent patients
innate leukocytes manifest dynamic distinct inflammatory responses upon challenges rising dosages pathogen associated molecular pattern molecules lipopolysaccharide lps differentiate signal strengths innate leukocytes may utilize distinct intracellular signaling circuitries modulated adaptor molecules toll interacting protein tollip one critical adaptor molecules potentially playing key roles modulating dynamic adaptation innate leukocytes varying dosages external stimulants tollip may serve negative regulator nuclear factor activated cells signaling pathway cells challenged higher dosages lps acts positive regulator low grade chronic inflammation leukocytes programmed subclinical low dosages lps review aims discuss recent progress understanding complex innate leukocyte dynamics relevance pathogenesis resolving versus non resolving chronic inflammatory diseases
history science filled examples key discoveries breakthroughs published landmark texts journal papers one trace origins whole disciplines paradigm shifting publications include copernicus revolutionibus orbium coelestium isaac newton philosophiae naturalis principia mathematica albert einstein papers relativity michael faraday paper electromagnetic induction sits proudly among works sense regarded almost immediate effect transforming world real sense others listed review status subject relationship magnetism electricity faraday paper delve details key experiments carried royal institution outlining clearly discovered process electromagnetic induction whereby electric current could induced flow conductor experiences changing magnetic field ideas would enable maxwell later development theory classical electromagnetism would directly lead development electric dynamo electric motor two technological advances foundations modern world commentary written celebrate anniversary journal philosophical transactions royal society
effective education reform depends successful realization school leadership carrying reform school principals middle leaders century examine traditional role understand complexities ambiguities characterizing various responsibilities within context school reform critical change agents system players formal leaders interpret reform demands translate school practices process sense making though sense making ongoing process school leaders undergo personally collectively policy reforms little attention paid role principals middle leaders perform sense makers literature review article explores sense making school leadership holistic approach demonstrates sense making framed theoretical empirical studies well suggests implications avenues future research
paper discusses potential bamboo building material western countries study presented bamboo culms environmentally financially assessed compared building materials common western europe steel concrete timber furthermore case study done temporary european bamboo buildings structures bridges order determine factors success failure building bamboo paper presents results studies indicate within certain boundary conditions consideration recommendations following case study bamboo sustainable building material western countries competitive materials commonly used elsevier ltd rights reserved
background scottish intercollegiate guidelines network national institute health care excellence guidelines stress importance assessing patients psoriasis psoriatic arthritis comorbidities associated severe disease quality life qol purpose study evaluate primary care management psoriasis relation disease severity qol patient perspective methods cross sectional survey adults years psoriasis managed primary care conducted scotland year patients psoriasis identified invited participate online telephone survey questionnaires included dermatology life quality index dlqi self administered psoriasis area severity index sapasi psoriasis epidemiology screening tool pest primary outcome measure dlqi secondary outcomes included demographics comorbidities involvement different body sites sapasi pest scores relationships measures analysed using univariate analysis results mean age patients years men median dlqi sapasi scores respectively current psoriasis treatments topical oral medications phototherapy biologics none despite sign recommendations patients dlqi least moderate effect qol seen specialist past year according pest scores patients symptoms suggestive psoriatic arthritis requiring rheumatology referral conclusion national recommendations fully implemented primary care patients psoriasis psoriatic arthritis
background poor adherence oral bisphosphonates bps mitigate therapeutic benefit osteoporosis significant clinical burden previous studies regarding adherence oral bps focused postmenopausal osteoporosis little attention given patients rheumatoid arthritis thus investigated compliance persistence oral bps treatment osteoporosis analyzed risk factors poor adherence female patients real setting methods retrospective longitudinal study including female patients oral bps newly initiated aug aug university rheumatology center south korea compliance quantified using year medication possession ratio mpr persistence defined duration initiation end bps therapy without interruption exceeding days seropositve defined positive test result presence either rheumatoid factor anti cyclic citrullinated peptide antibody results patients prescribed risedronate weekly received alendronate weekly received ibandronate monthly year mpr proportion patients year mpr total patients discontinued oral bps study period persistence bps year years years common cause non persistence adverse events followed poor health literacy cost compliance persistence monthly oral bps significantly lower weekly regimens respectively additionally patients seropositive showed better compliance persistence bps compared seronegative counterparts conclusions compliance persistence oral bps patients suboptimal real practice thereby limiting efficacy osteoporosis treatment extending dosing interval bps may improve medication adherence patients
one barriers entry computer programming schools lack tools support educators assessment student projects order amend situation paper presents scratch web application allows teachers students automatically analyze projects coded scratch used programming language primary secondary education worldwide check properly programmed learn mistakes get feedback improve code develop computational thinking skills one goals scratch besides supporting teachers evaluation tasks act stimulus encourage students keep improving programming skills aiming check effectiveness regarding objective workshops students range years run schools learners analyzed one scratch projects scratch read information displayed feedback scratch tried improve projects using guidelines tips offered tool results show end workshop students increased score consequently improved coding skills
article represents possibility using modified algorithm automatic controllers higher order derivatives control complex plants significant delay mathematical models control systems developed comparative analysis quality indexes derived transient responses carried
paper introduces new multiconnponent geocomposite geosynthetic concrete composite mat gccm unlike traditional geosynthetic clay layer gcl materials possess bentonite clay layer interlayer gccm formulated dry concrete mix impregnated three dimensional geotextile fiber matrix hardens upon hydration concrete shell dual distinction multicomponent material unique paper also provides summary basic properties uncured material hydration followed introduction important characteristics cured material mechanical properties presented uncured cured phases illustrate property transformation uncured cured state demonstrate contribution fibrous geotextile phase cured concrete phase product properties astm committee gcl test methods applied appropriate gccm material followed concrete testing cured material finally number applications material involve durable protection soil erosion high flow regimes hydraulic property test results endurance test results presented hydraulic results channel testing arrangement subjecting installed cured material high velocity water flow
developments ambient assistance systems energy consumption optimization home environments one main goals ambient intelligent systems work propose wearable standalone solution combines assistance task energy optimization task purpose develop real time mobile sound based device activity recognizer senses audible part environment support owner daily tasks help optimize terms resource consumption
tropics predicted become warmer drier understanding sensitivity tree species drought important characterizing risk forests climate change study makes use long term drought experiment amazon rainforest evaluate role leaf level water relations leaf anatomy plasticity response drought six tree genera variables osmotic potential full turgor turgor loss point capacitance elastic modulus relative water content saturated water content compared seasons plots control fall exclusion enabling comparison short long term plasticity traits leaf anatomical traits correlated water relation parameters determine whether water relations differed among tissues key findings osmotic adjustment occurred response long term drought treatment species resistant drought stress showed less osmotic adjustment drought sensitive species water relation traits correlated tissue properties especially thickness abaxial epidermis spongy mesophyll findings demonstrate cell level water relation traits acclimate long term water stress highlight limitations extrapolating results short term studies temporal scales associated climate change
objectivesto investigate single combined effect silodosin adrenoceptor antagonist imidafenacin antimuscarinic agent bladder function subacute bladder outlet obstruction boo model male rats methodspartial boo created male wistar rats ligating urethra steel rod day surgery frequent voiding remarkable voiding behavior measurement metabolic cage cystometric investigations conscious restrained condition conducted cumulative intravenous administration silodosin alone imidafenacin alone combination two drugs resultswhen compared sham rats boo rats showed increase bladder capacity residual volume mean amplitude number non voiding contractions nvcs accompanied increase bladder weight boo rats silodosin alone significantly decreased number nvcs whereas imidafenacin alone significantly decreased number mean amplitude nvcs combination administration lower doses silodosin imidafenacin significantly suppressed number mean amplitude nvcs conclusionsthe present results indicate suppressive effect silodosin imidafenacin alone synergic effect combination two drugs nvcs subacute boo model male rats
paper symbolic computation eckhaus kundu equation appears quantum field theory weakly nonlinear dispersive water waves nonlinear optics studied via hirota method virtue dependent variable transformation bilinear form obtained bilinear backlund transformation given help exchange formulae corresponding one soliton solution derived bright dark soliton solutions obtained propagation interaction bright dark solitons discussed analytically graphically interactions two solitons presented bound state two solitons suppressed via choice parameters elsevier inc rights reserved
background recent evidence suggests sexualized text communication sexting associated substance use sexual risk behaviors among young adults yet little known relationship among young adult african american gay bisexual men population disproportionately impacted hiv united states rapid advances mobile phone technology indicate clear need research using mobile health mhealth methods ecological momentary assessment ema serve viable counterpart retrospective evaluation methods using real time data collection assess sexting substance use among population objective objective pilot study describe ema study design protocol characterize study population assess feasibility random prompt text message based thrice daily ema days means prospectively studying sexting marijuana alcohol use among sample young adult african american gay bisexual men ages methods participants recruited flyers snowball sampling spring summer community based hiv aids prevention care support organization washington eligible participants enrolled one time person study visit consisted informed written consent participate study self administered survey semi structured interview enrollment training ema data collection commencing day study visit random prompt survey texted participants personal mobile phones times day day data collection period assessing mood texts sent texts received sexts sent sexts received marijuana want marijuana use alcohol use results ema feasibility tested self identified african american gay bisexual men mean age years random prompt survey questions responses including yes likert scale options total days ema observation retention rate participants participants responded random prompt surveys compliance rate providing total completed surveys surveys overall mean response time complete survey minutes significant positive associations ema texts sent received questions rho well sexts sent received queries rho conclusions use ema protocol potential useful research tool understanding episodic behaviors sexting substance use relatively understudied underserved population implications practice additional research needed maximize survey compliance
bridge suspension bridge constructed paper took bridge background analyzed whether could meet technical requirements thus providing reference safe operation bridge results show bearing capacity main girder sling stress safety factors main cables meet code requirement stress stiffening girder concrete exceeds code limits meanwhile impact temperature gradient load stiffening girder relatively large
paper describe ensemble roller learning based automated planner uses bagging approach enhance existing techniques learning planning policies previous policy style planning learning systems sort state successors based action predictions relational classifier however learning based planners produce several plans bad quality since difficult encode single classifier possible situations occurring planning domain propose use ensembles relational classifiers generate robust policies applications machine learning idea ensembles classifiers consists providing accuracy particular scenarios diversity cover wide range situations particular ensemble roller learns ensembles relational decision trees planning domain control knowledge different sets trees aggregated single prediction applied separately multiple queue search algorithm experimental results show ways using new policies produce average plans better quality
present study investigated whether supplementation different doses cerium dioxide nanoparticles ceo nps vitro maturation ivm prepubertal ovine oocytes influenced embryonic development vitro cumulus oocyte complexes derived ovaries slaughtered prepubertal sheep underwent ivm ceo nps matured oocytes fertilised vitro zygotes cultured days results demonstrated ceo nps internalised cumulus cells oocyte treatment ceo nps affect nuclear maturation intracellular levels reactive oxygen species oocytes percentage oocytes regular chromatin configuration cytoskeleton structures treated ceo nps similar oocytes matured absence ceo nps significantly higher treated ceo nps relative quantification transcripts cumulus cells oocytes matured ceo nps showed statistically lower mrna abundance bcl associated protein bax cell cll lymphoma bcl superoxide dismutase sod compared ceo nps group concentration ceo nps significantly increased blastocyst yield total inner cell mass trophectoderm cell numbers compared groups low concentration ceo nps maturation medium enhanced vitro embryo production prepubertal ovine oocytes
objective systematically review literature determine whether sedentary time associated cardiometabolic diseases risk factors among south asian adults six electronic databases searched identify studies examined association sedentary time cardiometabolic diseases diabetes cardiovascular disease risk factors body mass index bmi waist circumference lipids blood pressure glucose among south asian adults two independent reviewers performed abstract full text screening data abstraction quality assessments searching identified potential articles used analysis greater sedentary time associated increased likelihood diabetes higher bmi glucose thirteen studies higher quality results identified trend whereby greater sedentary time associated increased risk diabetes several cardiometabolic risk factors among south asian adults high quality studies needed identify whether risk factors independent physical activity levels inform culturally specific interventions south asians
borderline personality disorder bpd severe mental disorder characterized dysfunctional pattern affective instability impulsivity disturbed interpersonal relationships dialectical behavior therapy dbt effective treatment borderline personality disorder demand dbt far exceeds existing clinical resources patients bpd never receive dbt incorporating computer technology dbt could help increase dissemination immersive virtual reality technology becoming widely available mainstream consumers case study explored feasibility clinical potential using immersive virtual reality technology enhance dbt mindfulness skills training year old female diagnosed bpd prior using patient experienced difficulty practicing dbt mindfulness due emotional reactivity difficulty concentrating help patient focus attention facilitate dbt mindfulness skills learning patient looked virtual reality goggles illusion slowly floating computer generated river listening dbt mindfulness training audios urges commit suicide urges self harm urges quit therapy urges use substances negative emotions reduced mindfulness session mindfulness well accepted liked patient although case studies scientifically inconclusive nature results feasibility study encouraging future controlled studies needed quantify whether enhanced mindfulness training long term benefits increasing patient acceptance improving therapeutic outcome computerizing dbt skills treatment modules would reduce cost increase dissemination
thyroid hormones important development central nervous system since fetal thyroid gland functioning mid gestation transport maternal thyroid hormones across placenta essential early phases gestation maternal thyroid deficiency associated higher incidence neurodevelopmental disorders newborns relationship maternal hypothyroidism onset autism spectrum disorders asd offspring however still debated address issue used validated animal model prenatal hypothyroidism based administration thyroid peroxidase inhibitor methimazole mmi tap water rat dams gestational day delivery offspring tested behavioral tasks infancy pnds adolescence pnd capture core associated symptoms asd mmi exposed pups able vocalize controls separated nest showed intact social discrimination abilities homing behavior test adolescence offspring sexes show anxious phenotype elevated plus maze showed intact object recognition however mmi exposed male rats showed increased novelty directed exploratory behaviors solicited partner play showed interest novel rather familiar objects compared control rats results show prenatal mmi induced hypothyroidism cause rat offspring behaviors resemble core associated asd symptoms like deficits communication social interaction anxiety elsevier rights reserved
aimsunderstanding causes axonal pathology remains key goal pursuit new therapies target disease progression multiple sclerosis anterograde axonal transport many proteins vital axonal viability mediated motor protein kifa linked several neurological diseases study aimed investigate expression kifa protein associated cargoes amyloid precursor protein app neurofilament post mortem control white matter determine kifa expression influenced presence risk single nucleotide polymorphisms snps identified region kifa gene methodsusing immunoblotting assays analysed expression kifa app phospho isoforms cases controls resultswe found significant reduction kifa associated cargoes inverse correlation kifa app protein levels furthermore homozygous carriers risk gene snps show significantly lower levels kifa protein compared patients copies risk snps conclusionswe conclude reduced expression axonal motor kifa may important implications determining axonal transport deficits ongoing neurodegeneration
despite researchers considering time day important variable studies implicit food evaluations food intake time day effects implicit food evaluations yet tested positive implicit evaluations unhealthy food stimuli measured implicit association test iat predict behaviour toward stimuli assumed reflect automatic reactions outside conscious awareness control however recent research revealed controlled processing influence iat performance current study tested time day effects implicit evaluations unhealthy food measured iat specifically automatic controlled processes underlying iat performance sample undergraduate women aged years completed single category iat varying times day results revealed participation later day associated positive implicit evaluation unhealthy food mediated decrease ability inhibit positive food reactions controlled processing rather increase automatic positive reactions findings draw attention importance considering time day studies measuring aspects implicit cognition using tasks iat elsevier ltd rights reserved
recent initiative madhya pradesh india promote privately funded rainwater harvesting structures farmers land shown substantial economic livelihood benefits contrast many poorly functioning community managed rainwater harvesting programs individual decentralized rainwater harvesting structures led significant improvements availability irrigation water revival agricultural economy region substantial increases farmer incomes livelihoods since farmers state invested farm ponds investments highly cost effective farmers able recover initial investment approximately years longer terms impact studies needed initial assessment suggests farm rainwater harvesting ponds promising private small irrigation option madhya pradesh similar regions india elsewhere elsevier rights reserved
typical entanglement based quantum key distribution qkd protocols maximally entangled singlet states used standard way generate use parametric conversion low intensity laser beams way probability produce two entangled pairs negligible however one obtains cost large likelihood producing particles work ask question approach optimal one point view key generation rate case study take bbm protocol find optimal intensity beam show optimal intensities much higher ones typically used results generalized protocols based singlet states
approach permits capitalize expert knowledge business rules using agent based platform objective approach allow experts manage daily evolutions business domains without use technician allow implied participate development application accomplish daily tasks work therefore manipulation expert knowledge generates need information security associated technologies notion cryptography emerged basic concept business rules modeling purpose paper present cryptographic algorithm based approach integrate security aspect business rules modeling propose integrating agent based approach framework solution utilizes security agent domain ontology agent applies encryption decryption algorithm allow confidentiality authenticity integrity important rules increase security rules used hybrid cryptography order take advantage symmetric asymmetric algorithms performed experiments find best encryption algorithm provides improvement terms response time space memory security
previously described glu benzylpiperidin ethyl nhex iqm interesting multifunctional neuroprotective compound potential treatment neurodegenerative diseases describe new derivatives different synthetic routes chemoenzymatic solid phase synthesis aiming improve previously described route solution lipase catalysed amidation glu diesters benzyl aminoethyl piperidine studied using candida antarctica mucor miehei lipases cases alpha amidated compound obtained main product pointing regioselectivity independent reacting glu enantiomer nature lipase efficient solid phase route used produce new donepezil based glu derivatives resulting good yield micromolar concentrations new compounds inhibited human cholinesterases protected neurons toxic insults related alzheimer disease cerebral ischemia cns permeable compounds cbz glu oet benzylpiperidin ethyl blocked voltage dependent calcium channels protected rat hippocampal slices oxygen glucose deprivation becoming promising antialzheimer anti stroke lead compounds elsevier masson sas rights reserved
background substance use disorders older adults expected increase dramatically coming years given increased susceptibility cognitive deficits older substance users defined aged years due accelerated health decline observed population important consider functional correlates cognitive impairment older adults study details cognitive status older individuals attending outpatient drug alcohol treatment services seeks determine association cognitive impairment self reported daily functioning methods ninety nine clients aged years attending outpatient treatment services sydney australia participated cognition assessed using addenbrooke cognitive examination revised ace recent substance use australian treatment outcome profile physical mental health geriatric depression scale social isolation lubben social network scale activities daily living bayer adl scale also assessed results nearly two thirds participants screened positive cognitive impairment ace clients met cut scores mild cognitive impairment mci severe cognitive impairment respectively self reported seizure history predictor cognitive impairment conclusions results suggest cognitive impairment group common assessment cognitive status older group patients include identification cognitive impairment also encompass mental health social functioning greater understanding needs cohort also enable better ordination health welfare services tailored population
background syndemics illicit drug use hiv remain significant public health issues around world increasing concern regarding rapidly growing market new psychoactive substances particularly asia response japanese government increasingly banned substances recent years sought identify prevalence correlates use quasi legal psychoactive substances among people living hiv aids plhiv japan methods data derived nationwide survey plhiv conducted nine leading hiv aids care hospitals july december prevalence correlates use quasi legal psychoactive substances synthetic cannabinoids cathinone derivatives etc prohibited using time survey among male participants examined using multivariate survey logistic regression results among study participants majority male commonly used drug among men quasi legal psychoactive substances ever previous year multivariate analysis lifetime use tryptamine type derivatives meo dipt diisopropyl methoxytryptamine adjusted odds ratio aor confidence interval methamphetamine amphetamine aor independently associated recent quasi legal psychoactive substance use conclusions sample male plhiv japan quasi legal psychoactive substances commonly used drugs individuals ever used tryptamine type derivatives methamphetamine amphetamine likely report recent quasi legal psychoactive substance use suggesting potential shift drug use patterns regulated unregulated substances among population findings indicate need research examine implications hiv care
study examines statistical process control chart used detect parameter shift poisson integer valued garch ingarch models zero inflated poisson ingarch models ingarch models conditional mean structure similar garch models well known appropriate analyzing count data feature overdispersion special attention paid study conditional general likelihood ratio based clr glr cusum charts score function based cusum sfcusum chart performance proposed methods evaluated simulation study calculating average run length findings show proposed methods perform adequately clr chart outperforms glr chart increased shift parameters moreover use sfcusum chart particular found lead lower false alarm rate use clr chart
aims developing evaluating email based intervention ebi enhance alcohol related parenting skills reduce alcohol consumption among adolescents methods four weeks participating parents received weekly email containing scientific findings practical advice exercises relation topics alcohol related rule setting communication using randomised controlled trial drks data parents adolescents collected via self report online questionnaires analysed means repeated measures analysis variance findings controlling baseline parents intervention group scored higher informed parents girls parents boys self efficacy parents girls parents boys follow case boys successful maintaining strict rules alcohol consumption parents control group girls boys whose parents reported less heavy episodic drinking follow controlled baseline parents girls conclusions ebi positive effects alcohol related parenting may reduce heavy episodic drinking among boys since delivered via email programme considerable potential reach many parents low cost
paper presents three phase back back transformerless inverter online uninterruptible power supply applications inverter consists three phase three wire input rectifier stage three phase four wire output inverter stage ground wires tied together two stages sinusoidal pulse width modulation based division summation sigma digital control input stage controls power flow utility grid link regulates link voltage fulfills power factor correction output stage tracks three phase reference voltages proposed control laws derived based sigma digital approach take account effects link voltage fluctuation grid voltage distortion inductance variation due different current levels thus distortion input current output voltage filter inductor core size reduced significantly moreover circulating current common ground suppressed effectively simulated experimental results three phase back back transformerless inverter confirmed analysis discussion proposed control approach
energy consumption cellular networks receiving significant attention academia industry due significant potential economic ecological influence energy efficiency renewable energy main pillars sustainability environmental compatibility technological advancements cost reduction photovoltaics making cellular base stations bss key source energy consumption cellular networks powered solar energy sources long term promising solution mobile cellular network industry paper addresses issues deployment operation two solar powered global system mobile communications gsm bss deployed present gsm gsm study based characteristics south korean solar radiation exposure optimum criteria well economic technical feasibility various bss analyzed using hybrid optimization model electric renewables addition initial capital replacement operations maintenance total net present costs various solar powered bss discussed furthermore economic feasibility proposed solar system compared conventional energy sources urban remote areas
peptides derived third bcl homology domain renormalize apoptotic signaling antagonizing prosurvival bcl family members potential peptide drugs exhibit therapeutic activities limited barriers including short circulation half lives poor penetration cells diblock polymeric micelle carrier bim peptide recently described demonstrated antitumor activity cell lymphoma xenograft model berguig mol however disulfide linkage used conjugate bim peptide shown nonoptimal blood stability describe peptide macromonomer composed bim capped four amino acid cathepsin substrate fkfl possesses high blood stability cleaved release drug inside target cells employing raft polymerization peptide macromonomer directly integrated multifunctional diblock copolymer tailored peptide delivery first polymer block made macro chain transfer agent cta composed responsive endosomolytic formulation diethylaminoethyl methacrylate deaema butyl methacrylate bma second polymer block copolymer peptide polyethylene glycol methacrylate pegma pegma monomers two sizes investigated protein gel analysis high performance liquid chromatography coupled mass spectrometry showed incubation cathepsin specifically cleaved fkfl linker released active bim peptide pegma pegma maldi tof showed incubation peptide monomers alone human serum resulted partial cleavage fkfl linker however formulation peptides polymers protected serum mediated peptide degradation dynamic light scattering dls demonstrated dependent micelle disassembly polymer micelles versus run unimers red blood cell lysis assay showed corresponding increase membrane destabilizing activity lysis versus lysis full carrier drug system successfully induced apoptosis skov ovarian cancer cells dose dependent manner comparison control polymer containing scrambled bim peptide sequence mechanistic analysis verified target dependent activation caspase activity fold increase positive annexin staining increase increased blood stability enzyme cleavable peptide polymer design together direct polymerization approach eliminated postsynthetic conjugation steps suggests new carrier design could provide important benefits intracellular peptide drug delivery
family firms play significant role global economy although family firm literature devoted much time effort investigating topics concerning corporate governance leadership ownership succession accounting issues received relatively scant attention paper assemble critically review extant literature choice management controls essential topic firms management control systems mcs used make sure subordinates behave function goals firm family firms however distinct features differences governance structures goals significant impact whether mcs used conclude review paper providing avenues future research advance understanding determinants outcomes choice mcs
paper describes implementation two neuron emulator circuits first circuit provides electrical properties neuron seen single patch clamp electrode defined action potential charge output second circuit offers multi channel output adjustable phase delay provides responses typically seen longitudinal electrode peripheral nerve cuff intraneural electrode using prototype board emulators intended testing electrophysiological equipment patch clamp amplifiers multi channel devices aps generated voltage dependent frequency controlled microcontroller reported measured results confirm capability performing voltage clamp rate responsive current clamp techniques generating phase delayed outputs respectively
avian analogue human fronto executive dysfunction used study long term effects repeated low dose known selectively antagonize excitatory methyl aspartate receptors nmda indirectly impair inhibitory related processes gaba first eight pigeons divided two groups receiving either saline hour prior session thirty min sessions differential reinforcement low rate response drl schedule run months overall number responses efficiency unaffected treatment establishing sub threshold motoric dose another eight pigeons treated identically given operant visual discrimination task results demonstrated impairment fronto striatal function excitatory inhibitory processes group entire months session treatment cross showed saline group unaffected whereas saline group exhibited rapid recovery inhibitory control however excitatory control fully recover together results suggested nmda system involved acquisition excitatory learning expression inhibitory learning findings discussed terms value avian models translational research furthermore results examined within context nih research domain criteria initiative rule nmda disruption underlie executive dysfunction various neuropsychiatric disorders finally findings suggested potential long term effects clinical recreational use nmda antagoniks require study elsevier inc rights reserved
paper novel motor topology lateral stator machine proposed various drilling applications space tool head limited stator motor grows one lateral direction allowing compact direct drive design finite element analysis fea carried machine design optimized specifications high speed micro machining spindle given example design procedure specifications described detail torque maximized considering space limitations loss constraints critical operating points construction lateral stator machine merged test bench also described test bench used measuring standstill torque machine configuration without bearings electromagnetic torque measured without friction effects bearings moreover test bench modified measure load losses separate mechanical electromagnetic components although described lateral stator machine measurement methodology paper applied electrical machine finally measurement results given design procedure verified
study prenatal development sphenoid buffalo bubalus bubalis conducted department veterinary anatomy college veterinary science tirupati total buffalo embryos foctii starting day day collected different slaughter houses specimens fixed processed serial paraffin sectioning sections subjected different staining methods prechordal part formed basisphenoid caudally presphenoid cranially anterior end prechordal part joined nasal capsule prechordal part precartilaginous form days cartilaginous form days sphenoid developed six ossification centers ossification recognized first orbitosphenoid body basisphenoid alisphenoid days
recent years interest green building materials valorisation products multiple industries increasing brick industry allows various compounds added mixing procedure much research conducted highlight impact additions fired clay bricks paper examines significance adding organic matter coming agricultural solid waste olive stone flour osf wheat straw residues improve thermal performance maintaining load bearing capacity results show decreasing bulk density mixtures containing osf ranging compared clay alone mixtures bulk density reduction total porosity increases osf implying lower thermal conductivity relative clay alone compared osf incorporated compressive strength osf respectively significant positive correlation increasing amount organic matter porosity striking result emerge data creates higher total pore volume osf owing difference grain size distribution consequently pore size distribution new materials containing osf structured leads better compressive strength elsevier ltd rights reserved
view biomass gasification processes nonlinear non minimum phase characteristics instability dynamic process characteristics large delay load disturbance contains large number uncertainty factors accurate mathematical model hard express using single control algorithm design general control system difficult achieve desired effect puts forward fuzzy pid fuzzy control technology combined conventional pid control algorithm achieve better control temperature gasifier furnace
background recent studies shown significant association restless legs syndrome rls primary headache disorders nevertheless information regarding association tension type headache tth rls limited study aimed investigate association rls tth population based sample methods selected stratified random population sample koreans aged years assessed using semi structured interview designed identify rls headache type clinical characteristics tth determined prevalence clinical impact rls participants tth results participants classified tth rls respectively among individuals tth also met criteria probable migraine prevalence rls significantly higher among individuals tth among non headache prevalence rls significantly higher subjects tth fulfilled criteria non headache participants however rls prevalence individuals tth fulfil criteria differ participants non headache tth participants rls higher visual analogue scale scores headache intensity higher prevalence anxiety depression tth participants without rls multivariable analyses revealed headache aggravation movement odds ratio confidence interval depression significant indicators rls among individuals tth conclusion prevalence rls higher among individuals tth among non headache clinical presentations varied accordance presence rls among participants tth
increased penetration renewable energy sources existing power systems led necessary developments electricity market mechanisms importantly renewable energy generation increasingly made accountable deviations scheduled actual energy generation however mechanism enforce accountability additional costs induced power fluctuations costs socialized eventually supported electricity customers propose metrics assessing contribution market participants power regulation needs well attribution mechanism fairly redistributing related power regulation costs discuss effect various metrics used attribution mechanisms illustrate game theoretical framework consequences strategic behavior market participants also illustrate using case western denmark mechanisms may affect revenues various market participants
general operating systems oss designed mediate access device hardware applications process different kinds system calls using indiscriminate kernel configuration applications cloud computing platforms constructed service components service components assigned separately individual virtual machine leads homogeneous system calls addition requirements kernel function configuration system parameters different vms different therefore suit design incurs unnecessary performance overhead restricts processing capacity cloud computing paper propose adaptive model cloud computing resolve conflict generality performance model adaptively specializes according resource consuming characteristics workloads implement prototype adaptive model vspec five classes cpu intensive memory intensive intensive network intensive compound according resource consuming characteristics workloads running vms vspec specializes according class perform comprehensive experiments evaluate effectiveness vspec benchmarks real world applications
many regions russia centralized electricity supply geographical location taking account variable electricity generation available energy storage systems well stricter requirements imposed consumers power quality electricity supply reliability say operating conditions systems control including emergency control represent difficult problem needs studied generation wind power plants however vivid example stochastic operation generators research aimed developing algorithms construction automated systems control active components electrical network method applied research describe object control based universal approach mathematical modelling nonlinear dynamic system black box type represented volterra polynomials degree makes possible input output characteristics object obtain adequate fast mathematical description results computational experiment demonstrate applicability mathematical tool control active components intelligent power system
naturalistic study examined differences students motivations elective versus required service learning classes students two successive academic years cohorts surveyed center large midwestern university analyses compared classes differing requirements community based service students required participate community service part class within program required admission university less likely want involved future community work enroll another class recommend class compared groups students including others classes required part program students enrolled findings suggest students motivations participate community engaged activities shaped simply whether community engagement required classes also factors including engagement opportunity contextualized
thermal loads especially thermal gradients considerable effect behaviors large scale bridges throughout lifecycles bridge design specifications provide minimal guidance regarding thermal gradients simple bridge girders consider transversal thermal gradients wide girder cross sections paper investigates three dimensional thermal gradients arch bridge girders integrating long term field monitoring data recorded structural health monitoring system emphasis vertical transversal thermal gradients wide concrete steel composite girders based field monitoring data one year time dependent characteristics temperature three dimensional thermal gradients girder cross sections explored statistical analysis thermal gradients conducted probability density functions transversal vertical thermal gradients estimated extreme thermal gradients predicted specific return period employing extreme value analysis profiles vertical thermal gradient established bridge design transversal vertical thermal gradients developed help engineers understand thermal behaviors concrete steel composite girders service periods
three different multicomponent geosynthetic clay liners gcls different manufacturers tested transmissivity cell new testing procedure quantify flow rate interface transmissivity coating attached film presenting hole upper geotextile gcl testing device previously used studies aiming evaluate interface transmissivity damaged geomembrane regular gcl different results obtained regarding evolution time flow rate ranging steady state average range flow rate results obtained gcl composite liner additional tests performed adding top give lower values flow rates shows importance film coating rigidity decreasing flow rate insuring better quality contact interface
field shock wave physics provided significant insights many processes related wave propagation materials exact operative micromechanisms defect generation occurring shock thereafter controlling defect storage damage evolution remain incompletely understood poorly modeled attainment truly predictive capability enable accurate simulations dynamic impact shock high rate loading phenomena applications requires linked experimental modeling validation research program talk overview microstructural mechanisms affecting strength materials high pressure strain rates well processes controlling damage evolution shock loading reviewed spectrum physical phenomena potential nation wide experimental facilities poised study discussed addition limitations caveats involved using velocimetry single pass radiography shock recovery alone elucidate aspects defect generation storage recovery examined detail examples real time post mortem experimental approaches needed quantify dislocation defect generation shock induced phase transitions damage evolution spallation discussed
probiotic supplementation promising preventive strategy atopic dermatitis help clarifying significance timing respect prevention evaluate benefit prophylactic use probiotic supplementation neonates younger weeks gestation preterm children department neonatology rigshospitalet denmark two different admission periods included historically controlled cohort study neonates january february treated neonates march february treated probiotic enrolled main outcome prevalence secondary outcomes use topical corticosteroids number skin related visits gps dermatologists preterm neonates included study treated treated probiotics response rate two cohorts respectively prevalence similar two groups probiotic treated group versus treated group significant differences found groups respect treatment topical corticosteroids visits gps dermatologist found indication probiotics may prevent administered neonates gestation weeks birth discharge home factors influencing early maturation immune system assumed particular importance atopic dermatitis hence unique cohorts contribute information probiotic supplementation may affect extremely immature immune systems preterm infants
poly ethylenedioxythiophene pedot films electrochemically deposited glassy carbon disk electrodes using aqueous solutions containing ethylenedioxythiophene edot sulfonated calixarenes fullerene sulfonated calixarene calixarene complexes edot monomer added aqueous sulfonated calixarene solutions without solutions pedot calixarene pedot calixarene films electrochemically deposited disk electrodes electrochemical properties pedot calixarene compared pedot doped ions aqueous organic electrolyte solutions using cyclic voltammetry electrochemical impedance spectroscopy eis measurements carried pedot calixarene aqueous kcl solution showed reduction peak agcl kcl first potential scan attributed irreversible reduction inside pedot film additional reduction peak however observed recording cvs organic solution indicating dissolved pedot film organic electrolyte solution good solvent performing measurements organic electrolyte solution containing pedot electrodes various doping ions bare electrodes showed reversible reduction peak characteristic redox couple interestingly peak potential shape reoxidation peak fulleride anion pedot organic electrolyte solution found depend pedot film thickness electrochemical properties pedot calixarene compared pedot calixarene fitting eis data equivalent electrical circuits morphology studied scanning electron microscopy elsevier ltd rights reserved
aimthe actionable bladder symptom screening tool absst used identify multiple sclerosis patients possible need evaluation urinary symptoms primary objective study identify barriers experienced patients seeking evaluation urinary symptoms also assessed utility absst tool identifying patients follow urologic evaluation methodsthis prospective observational study patients enrolled center patients completed demographic information questions assess barriers care short form absst incontinence questionnaires absst score met criteria referral evaluation one year enrollment follow calls assessed whether patients seen urinary specialist resultsthe common barriers seeking care included doctor never referred doctor never asked thirty eight percent men stated doctor never referred compared women twenty seven patients absst score interested seeing specialist compared scoring year patients reached follow total patients followed evaluation screened positive absst conclusionsthe absst valuable tool identify patients urinary symptoms likely follow genitourinary evaluation however barriers beyond awareness exist prevent patients evaluated
rationale environmental challenges adolescence drug exposure cause enduring behavioral molecular changes contribute life long maladaptive behaviors including addiction selectively bred highresponder bhr low responder blr rats represent unique model assessing long termimpact adolescent environmental manipulations inherently differ number addiction related traits bhr rats consideredbaddiction prone whereas blr rats baddictionresilient least baseline conditions moreover relative blrs bhr rats likely attribute incentive motivational value reward cues bsign track objectives utilized bhr blr rats determine whether adolescent cocaine exposure alter inborn behavioral neurobiological profiles specific focus pavlovian conditioned approach behavior sign goal tracking hippocampal neurogenesis methods bhr blr rats administered cocaine saline days adolescence postnatal day pnd subsequently tested pavlovian conditioned approach behavior adulthood pnd wherein illuminated lever conditioned stimulus followed response independent delivery food pellet unconditioned stimulus behaviors directed toward lever food cup recorded sign goal tracking respectively hippocampal cell genesis evaluated pnd immunohistochemistry results adolescent cocaine exposure impaired hippocampal cell genesis proliferation survival enhanced inherent propensity goal track adult blr bhr rats conclusions adolescent cocaine exposure elicits long lasting changes stimulus reward learning enduring deficits hippocampal neurogenesis selectively adult blr rats conclusions adolescent cocaine exposure elicits long lasting changes stimulus reward learning enduring deficits hippocampal neurogenesis selectively adult blr rats
study graphene patterns using laser induced chemical vapor deposition lcvd visible laser lambda irradiation room temperature investigated optically pumped solid state laser wavelength irradiates thin nickel foil induce local temperature rise thereby allowing direct writing graphene patterns similar width high growth rate precisely controlled positions demonstrate fabrication graphene patterns achieved single scan graphene pattern using lcvd annealing preprocessing substrate scan speed reaches similar indicates graphene pattern unite area grown sec number graphene layers controlled laser scan speed substrate fabricated graphene patterns nickel foils directly transferred desired positions patterned electrodes position controlled transfer rapid single step fabrication graphene patterns provides innovative pathway application electrical circuits devices
evaluated influence degenerative disease fractured vertebra lumbar spine bone mineral density bmd trabecular bone score tbs women aged years tbs affected degenerative disease bmd increases years tbs continues decline tbs play leading role lumbar spine evaluation menopause lumbar spine bmd tbs values decrease degenerative disease increases age affect bmd aim study measure changes bmd tbs women years old taking account impact fractured vertebrae bmd tbs vertebral fracture assessment evaluated osteolaus cohort women years old exams analyzed following iscd guidelines identify vertebrae fractures vex women enrolled mean age years bmi bmd tbs weakly correlated correlation vex excluded age bmd age tbs according age group bmd higher excluding vex tbs insignificant change excluding vex bmd vex decreased years increased years tbs vex excluded values decreased steadily age overall loss years spine tbs femoral neck total hip bmd gradually decreased age reaching one oldest youngest group tbs affected bmd increases years tbs continues decline lumbar spine evaluation view independence tbs play leading role diagnosis complement bmd
paper deals nonlinear dynamic modeling proton exchange membrane fuel cell pemfc dedicated automotive applications time variant state space model taking account internal phenomena built based electrical diffusion approaches model proposes complete equivalent circuit including cell components proposed circuit couple gas diffusion membrane water content temperature activation ohmic concentration losses well double layer geometrical capacitances similarly engine vehicles model consider hydrogen flow rate input controlled pilot change vehicle speed urban highway driving cycles similar nissan leaf simulated simulation results show model responds low high dynamics power demand results reveal membrane humidity considerable effect cell efficiency offer opportunity use model future work improve fuel cell efficiency control humidity model validated experimental tests pemfc elsevier rights reserved
video lectures finding way education numerous advantages used different contexts within formal non formal informal education control systems subject formal education viewed practitioner angle paper describes video lecture control systems sponsored abb available youtube lecture developed control practitioners audience strong engineering background engineering background shown linkage real world difference formal control systems lectures course discussed ifac international federation automatic control hosting elsevier ltd rights reserved
analysis reported three time level integration methods following global spectral analysis gsa described high accuracy computing methods sengupta cambridge univ press usa focus second order adams bashforth extrapolation time ext methods careful distinction made first time step either euler forward four stage fourth order runge kutta time schemes latter used solve benchmark aeroacoustic problem several one dimensional wave propagation models analyzed pure advection advection diffusion equations various spatial discretizations discussed including fourier spectral method attention paid presence physical numerical modes noted quadratic equation obtained difference equation model convection equation shown method less stable accurate ext method respect numerical dissipation dispersion true methods physical mode dominates numerical mode presented analysis provides useful guide analyze three time level methods elsevier inc rights reserved
objectives determine healthy people aged years restricting time bed education health sleep practices superior attention control condition education healthy dietary practices maintaining enhancing sleep continuity depth years maintenance enhancement sleep continuity depth promotes maintenance enhancement health related quality life methods single blind randomized clinical trial university based sleep center enrolling adults women men mean age years without sleep wake complaints insomnia daytime sleepiness followed randomized assignment either restriction time bed delaying bedtime minutes nightly months together education healthy sleep practices sleep attention control condition education health dietary practices nutrition results sleep enhance sleep continuity depth however compared nutrition sleep associated decreased time spent asleep minutes nightly months contrary hypothesis participants sleep reported decrement physical health related quality life increase medical burden cardiovascular illness relative nutrition neither markers inflammation body mass index exercise explained treatment related changes medical burden conclusions although exclude positive effect education healthy nutrition healthy elderly years age without sleep complaints reducing sleep time may detrimental whereas allowing time sleep hours nightly associated better maintenance physical health related quality life stability medical illness burden months
role dopamine type receptor expressing neurons regulation motivated behavior reward prediction yet fully established prerequisite future research assessing mediated neuronal network regulation using simultaneous pet mri selective sch study investigated stability central measurements two independent pet mri sessions baseline conditions thirteen healthy volunteers female age yrs underwent min emission scans bolus injection mbq sch two separate days within weeks using pet mri system parametric images distribution volume ratio dvr binding potential bpnd generated multi linear reference tissue model two parameters cerebellar cortex receptor free reference region volume interest voi analysis performed manual vois drawn consecutive transverse mri slices brain regions high low density dvr varied regions high density head caudate regions low density prefrontal cortex absolute variability dvr ranged bland altman analyses revealed low differences mean dvr nucleus accumbens intraclass correlation one way random indicated high agreement average dvr bpnd values accordingly absolute variability bpnd ranged however regions low content occipital cortex higher mean variability test retest reliability measurements study high case rich brain areas also regions low density results provide solid base future joint pet mri data analyses stimulation dependent mapping containing neurons effects projections neuronal circuits determine behavior
mds matrices great importance design block ciphers hash functions mds matrices sparse large description thus induce costly implementation software hardware overcome problem particular applications light weight cryptography proposed guo use recursive mds matrices recursive mds matrix mds matrix expressed power companion matrix following work guo hoc search techniques proposed find recursive mds matrices suitable hardware software implementation another direction coding theoretic techniques used directly construct recursive mds matrices berger technique uses gabidulin codes augot technique uses shortened bch codes paper first characterize polynomials yield recursive mds matrices general setting based provide three methods obtaining polynomials moreover recursive mds matrices obtained using shortened bch codes also obtained first method fact get larger set polynomials method uses shortened bch codes methods appear similar method uses gabidulin codes get new infinite class recursive mds matrices one proposed methods although propose three methods direct construction recursive mds matrices characterization results pave way new direct constructions
transcription factor gata regulates expression essential erythroid megakaryocytic differentiation genes binding dna consensus sequence wgatar gata protein four functional domains including two centrally located zinc finger domains two transactivation domains termini functional domains play characteristic roles elaborate regulation diversified gata target genes exhibits unique expression profile three types gata related hematological malignancies reported one structural mutation gata gene resulting production short form gata lacks terminal transactivation domain found syndrome related acute megakaryocytic leukemia two cis acting regulatory mutations affecting expression gata gene shown cause acute erythroblastic leukemia myelofibrosis mice therefore imbalanced gene regulation caused qualitative quantitative changes gata thought involved specific hematological disease pathogenesis present review discuss recent advances understanding mechanisms differential transcriptional regulation gata erythroid differentiation special reference binding kinetics gata conformation specific binding sites
work capacitance multiplier designed using negative current feedback operational amplifier proposed circuit low sensitivity temperature variations simulation results obtained pspice simulations verify theoretical analysis khz mhz
purpose retrospective review prospectively acquired whole body magnetic resonance mri scans assess incidence osteonecrosis patients received different chemotherapies evaluated mri scans performed patients hodgkin lymphoma treated three chemotherapy regimens abvd abvd beacopp abvd beacopp excluding patients main risk factors osteonecrosis six seven patients received eight beacopp one five patients treated four beacopp presented osteonecrosis statistically significant difference frequency two groups patients injury reported patients treated abvd among total osteonecrotic lesions observed detected knee multifocal osteonecrosis detected six seven patients development osteonecrosis strictly related chemotherapy protocol adopted number cycles received strong correlation dose corticosteroids included beacopp scheme complication mri considered helpful tool allows detecting earlier osteonecrotic lesions patients treated corticosteroids aeuro cent osteonecrosis possible complication patients lymphoma treated chemotherapy aeuro cent osteonecrosis related corticosteroids included within beacopp protocol aeuro cent mri allows detecting osteonecrotic lesions patients treated corticosteroids
paper describes development new approach speed governors small hydropower plants shps employing servo pneumatic positioning system pneutronic system aiming cost reduction easy maintenance obtaining environmentally friendly product pneumatic system designed control wicked gates francis turbines replace conventional approach using hydraulic system positioning system development based non linear modeling pneumatic valve cylinder includes pid controller dead zone compensation using test bench corresponding power plant model validated performance requirements according international standards fully satisfied results presented speed governor prototype installed site francis turbine load rejection step response tests carried theoretical experimental results show servo pneumatic speed governor used successfully shps restricted turbines considering pneumatic component costs
prevalence embedded systems various fields spread real time operating systems rtoss widely used many years satisfying real time requirements multitasking design use rtos adds additional overhead system deliberately considered evaluated critical systems paper presents qualitative quantitative comparison open source rtos freertos commercial one iii rtos use preemptive multitasking kernel additional support round robin scheduling aim benchmark evaluate performance behaviour including seven performance tests two behaviour tests comparing measurement results shows commercial iii behave much better freertos furthermore discovered priority changing function osiii behave correctly circumstances although freertos problem latest version still problem dynamic memory management
pseudokinase complement human kinase superfamily consists approximately signaling proteins lacks one amino acids typically required correctly align atp metal ions phosphorylate protein substrates recent studies pseudokinase field begun expose biological relevance pseudokinases thought perform diverse range physiological roles connected multitude human diseases including cancer review discuss members pseudokinome represent important new targets drug discovery describe knowledge protein structure function provides informative clues help guide rational chemical design repurposing inhibitors target pseudokinases
background vitamin deficiency common middle east saudi arabia particular several international recommendations management vitamin deficiency documented practiced globally recommendations adapted conditions middle eastern region address challenge prince mutaib chair biomarkers osteoporosis pmco king saud university ksu riyadh ksa together local experts cooperation european society clinical economic aspects osteoporosis osteoarthritis esceo organized panel formulated unified recommendations diagnosis treatment vitamin deficiency region methods selection local international experts commenced international vitamin symposium conducted riyadh saudi arabia last january reviews recent literature done face face meetings conducted revisions final recommendations results vitamin sufficiency defined circulating serum nmol general population vitamin adequacy serum nmol frail osteoporotic elderly despite overwhelming prevalence vitamin deficiency universal screening recommended recommendations general population children pregnant lactating women postmenopausal women elderly subsequent metabolic diseases provided results vitamin sufficiency defined circulating serum nmol general population vitamin adequacy serum nmol frail osteoporotic elderly despite overwhelming prevalence vitamin deficiency universal screening recommended recommendations general population children pregnant lactating women post menopausal women elderly subsequent metabolic diseases provided conclusion vitamin supplementation correction advised persons whose serum falls nmol achieving target nmol particularly suited frail osteoporotic older patients conducting well designed clinical trials region address economic implications investigations treatment persistence compliance vitamin treatment region encouraged
present research study presents optimization solid oxide fuel cell sofc power plants directly fed biogas considering energy exergy balances system detailed thermodynamic model thermas designed implemented specific sofc based system selected case study equipped three heat exchangers preheaters reformer sofc stack system afterburner use simulation tool thermas give opportunity investigate appropriate parameters affect system efficiency based exergy analysis incorporating detailed parametric analysis regarding whole system optimization process relies difference energy exergy efficiency considering innovative optimization factor opf simulated system dynamically affected operational parameters fuel composition extension chemical reactions temperatures found use pure fuels seems meaningless without optimization elsevier ltd rights reserved
article aims shed light self perceptions people eating disorders malta italy deep understanding narratives contrast biomedical perception phenomenon opposition prevalent feminist theories subject consider eating disorders result self transformative processes suggest anorexics bulimics binge eaters actively deliberately engaged project moral self transformation culturally defined moral transformations women eating disorders malta italy two considered contexts research reflect social expectations women societies drastic changes personal attitudes towards food body characterise eating disorders result complete dedication moral values embodied thinness namely control bodily needs pleasure self transformative process people eating disorders understood form moral conversion along continuum increasing control hunger higher control higher level satisfaction degree moral conversion achieved considering general low recovery rates people eating disorders approach helps understanding people diagnosed eating disorder accept medical definitions treatments different extents
systematic review meta analysis synthesized findings studies examining culturally sensitive substance use treatment racial ethnic minority youth extensive literature search located eight eligible studies using experimental quasi experimental designs meta analysis quantitatively synthesized findings comparing seven culturally sensitive treatment conditions seven alternative conditions samples composed least racial ethnic minority youth results meta analysis indicated culturally sensitive treatments associated significantly larger reductions post treatment substance use levels relative comparison conditions total number participants average time pretest posttest weeks statistically significant amount heterogeneity across seven studies differential effects statistically significant contrasts active generic counterparts treatment conditions direct bona fide comparisons treatment usual conditions strong conclusions review hindered small number available studies synthesis variability comparison conditions across studies lack diversity adolescent clients served studies nonetheless review suggests culturally sensitive treatments offer promise effective way address substance use among racial ethnic minority youth elsevier inc rights reserved
past research provided abundant evidence playing violent video games increases aggressive tendencies contrast evidence possible positive effects video game exposure prosocial tendencies relatively sparse present research tested found support hypothesis exposure prosocial video games increases accessibility prosocial thoughts results provide support predictive validity general learning model buckley anderson effects exposure prosocial media social tendencies thus depending content video game playing video games harm may also benefit social relations
paper reviewed four key themes study clean power transition china resources potential technology advancement air pollution control policy reform power sector theme summarized ongoing research development highlighted key areas study given china power sector transition huge task hope review add discussions ongoing conversation elsevier rights reserved
confocal raman spectroscopy implemented new label free technique quantify molecular diffusion coefficients within gels leading anti hiv drug tenofovir analyzed clinical microbicide gel gel tested undiluted dilutions vaginal fluid simulant capture range conditions likely occurring vivo concentration distributions tenofovir gel time space measured input mathematical diffusion model deduce diffusion coefficients undiluted gel increased depending extent dilution results interpreted respect traditional release rate measurements devices franz cells comparison highlighted advantage assay characterizes diffusive barrier within gel material contrast release rate traditional assay affected external conditions drug partitioning gel liquid sink interface new assay relevant diffusion polymeric hydrogels pharmacologically relevant length scales example characteristic topical drug delivery resulting transport parameters salient measures drug delivery potential serve inputs computational models drug delivery performance american pharmacists association published elsevier inc rights reserved
background endogenous sex hormones related cardiovascular outcomes mortality hypothesized sex hormones related atrial fibrillation community based cohort middle aged older men methods results examined testosterone estradiol dehydroepiandrosterone sulfate relation incident men participating framingham heart study assessed year risk multivariable adjusted hazard models cohort consisted men age years developed incident identified significant interaction age testosterone therefore stratified men age years years years men aged years decrease testosterone associated hazard ratio confidence interval incident association testosterone year incident men years reach statistical significance men years decrease testosterone associated risk estradiol associated incident dehydroepiandrosterone sulfate borderline association risk statistically significant conclusions testosterone estradiol associated incident cohort older men testosterone deficiency men years strongly associated risk clinical electrophysiological mechanisms underlying associations sex hormones older men merit continued investigation
efficacy safety alectinib central nervous system active selective anaplastic lymphoma kinase alk inhibitor demonstrated patients alk positive alk non small cell lung cancer nsclc progressing crizotinib alectinib mainly metabolized cytochrome cypa major similarly active metabolite alectinib show evidence weak time dependent inhibition small induction cypa vitro present results fixed sequence studies evaluating drug drug interactions alectinib cypa studies enrolled healthy subjects respectively investigated potent cypa inhibition posaconazole potent cypa induction rifampin respectively single oral dose pharmacokinetics alectinib substudy global phase study enrolled patients alk nsclc determine effect multiple doses alectinib single oral dose midazolam sensitive substrate cypa potent cypa inhibition induction resulted minor effects combined exposure alectinib multiple doses alectinib influence midazolam exposure results suggest dose adjustments may needed alectinib coadministered cypa inhibitors inducers coadministered cypa substrates
scientific advances allowed development multiplex gene panels assess many genes simultaneously women tested negative brca examined correlates interest testing genes confer modest moderate breast cancer risk risk communication preferences women brca negative families female first degree relatives breast cancer patients tested negative brca mutations completed survey assessing multiplex genetic testing interest risk communication preferences interest testing high even higher results could guide risk reducing behavior changes taking medications participants preferred receive genomic risk communications variety sources including primary care physicians genetic counselors printed materials web factors independently associated testing interest perceived lifetime risk developing cancer odds ratio confidence interval high cancer worry findings suggest women brca negative families unique population may primed behavior change findings also provide guidance clinicians help develop genomic risk communications promote informed decision making customize behavioral interventions
objectives provide novel quantification advanced measurements surface temperatures playgrounds employing multiple scales data provide insight hot hazard mitigation techniques designs improved environmental public health methods conduct analysis two metro phoenix playgrounds three scales neighborhood resolution microscale resolution touch scale resolution data derived two sources airborne remote sensing neighborhood microscale situ playground site infrared touch scale metrics surface air temperature deltas delta scale offsets errors introduced results select situ direct sunlight shown approach surpass values likely result burns children touch scales much finer resolved airborne remote sensing scale offsets based neighbourhood microscale ground observations degrees degrees less delta touch scale respectively degrees degrees lower touch scale playground equipment respectively hence coarser scales underestimate high within playgrounds natural tree artificial shade sail shade types associated significant reductions conclusions scale mismatch exists based differing methods urban measurement sub meter touch scale spatial scale data must collected policies urban landscape design health must executed order mitigate high high contact environments playgrounds shade implementation promising mitigation technique reduce child burns increase park usability mitigate urban heating elsevier rights reserved
japan ministry environment conducting large scale birth cohort study called japan environment children study jecs involves mother child pairs mothers enrolled pregnancy children followed studied reach age years jecs started recruiting mothers january completed registration mothers march national institute environmental studies takes lead study programming implementation cooperation national centre child health development regional centres reach study participants study effects environmental factors children health development investigated environment study defined air soil water indoor environments also various chemical substances physical conditions socioeconomic factors psychological conditions lifestyles community situations mothers children exposures environmental factors measured chemical analyses biospecimens collected pregnancy birth questionnaires computer modelling homes randomly selected participants visited measure concentrations volatile organic compounds nitrogen sulphuric oxides particulate matter vacuum dust samples also collected chemical analysis data combined information collected dwelling unit observation assess exposure children aged years
helpfulness user generated reviews studied adequately terms interplay review sentiment favorable unfavorable mixed product type search experience moreover ways information quality relates review helpfulness remain largely unknown hence paper seeks answer following two research questions helpfulness user generated reviews vary function review sentiment product type information quality relate helpfulness user generated reviews across review sentiment product type data included reviews drawn amazon three search products digital cameras cell phones laser printers well three experience products books skin care music albums review sentiment ascertained based star ratings investigation research questions relied statistical procedures analysis variance multiple regression review helpfulness found vary across review sentiment independent product type besides relationship information quality review helpfulness found vary function review sentiment well product type paper concludes number implications research practice elsevier ltd rights reserved
paper new solution proposed remote monitoring control distributed generators dgs energy storage systems esss connected low voltage distribution networks proposed system fulfills force standard requirements connection dgs utility grid moreover allows implementing enhanced functions remote control inverters dgs esss terms disconnection also terms voltage regulation power shuttering proposed solution based new interface protection system dedicated secondary substation concentrator allows communication distributed system operator inverters dgs esss proposed system tested field electrical network island ustica experimental characterization carried find best communication conditions frequency band lowest noise attenuation considering signal amplitude signal noise ratio constraints well desired transmission data rate transfer time
background cross sectional epidemiologic studies shape association serum concentrations perfluoroalkyl acids pfaas lipids suggests departures linearity objectives used statistical approaches allowing non linearity determine associations prenatal exposures perfluorooctane sulfonic acid pfos perfluorooctanoic acid pfoa lipid concentrations methods pfaas measured serum pregnant women collected enrollment avon longitudinal study parents children lipids serum daughters ages associations pfaas lipids first explored cubic splines followed piecewise linear regressions tertiles obtain regression coefficients beta confidence limits per results age total cholesterol positively associated prenatal pfoa concentrations lower tertile beta pfoa concentrations middle beta upper beta tertiles age similar pattern noted well positive associations ldl prenatal pfoa concentration lower tertile observed daughters ages beta beta ldl associated pfoa concentrations middle upper tertile age neither hdl triglycerides associated prenatal pfoa exposure non linear patterns association total cholesterol ldl prenatal pfos less consistently noted conclusion exposure low levels pfoa prenatal development may alter lipid metabolism later life given small sample size replication association large independent cohorts important published elsevier ltd
background inconsistent evidence product effectiveness prevent moist desquamation radiation treatment minimal research acceptability patients recommended products prompted study objective randomized controlled trial compared effectiveness creams minimizing incidence moist desquamation tropical setting explored product acceptable patients receiving radiation treatment methods participants stratified according breast chest wall radiation treatment randomly allocated use moisturizing barrier cream nurses assessed radiation skin reactions weekly standardized grading system patients telephoned month completing treatment final skin assessment participants completed acceptability survey similar times results treatment completion participants moist desquamation additional self reported follow risk factors moist desquamation included increased breast cup size body mass index barrier cream significantly reduced incidence moist desquamation treatment patients receiving radiation chest wall participants preferred barrier cream moisturizer treatment conclusions study identified relatively high incidence moist desquamation patients receiving radiation therapy breast cancer future patients information product effectiveness minimizing moist desquamation choosing skin care products implications practice structured discharge planning patient education need include information factors contribute likelihood developing moist desquamation
soymeal contains natural plasticizer tackifier used fabricate biodegradable low cost warp sizes potential replacing non biodegradable polyvinyl alcohol pva sizes large quantity industrial applications warp sizes soyprotein isolates spi reported potential substitute pva sizes contribute high chemical oxygen demand textile effluents cause serious water pollution however sizes spi high cost need additional plasticizers overcome brittleness films research developed low cost soymeal sizes contain soyprotein majority saccharides saponified oil soymeal minorities comparing films triethanolamine plasticized spi sizes soymeal size higher film flexibility adhesion yarns abrasion resistance respectively saccharides soymeal saponified oil formed size extraction functioned plant based additives capability improving adhesion protein sizing pastes cotton polyester yarns increasing elongation protein based size films successful utilization soymeal textile sizing lead large quantity application resulting high value addition agricultural byproducts profound impact soybean industry textile industry elsevier rights reserved
shot peening improve fatigue strength materials creating compressive residual stress field surface layers offers protection crack initiation propagation corrosion etc fatigue fracture stress corrosion cracking nak steel parts improved effectively currently lacks depth research beneficial effect residual stress may offset surface damage associated shot peening especially terms research effective control shot peening intensity order obtain surface residual stress field nak steel shot peening samples shot peened pneumatic shot peening machine different rules residual stress precipitation hardening layer nak steel measured shot peening treatment ray diffraction method order obtain true residual stress field integral compensation method used correct results setting analytical model residual stress process shot peening surface residual stress calculated shot peening mentioning reason errors occurred calculated experimental residual stresses mainly caused measurement error shoot arc height time micro hardness microstructure roughness precipitation hardening layer nak steel shot peening measured surveyed order obtain relation shot peening strength surface quality precipitation hardening layer results show surface quality nak steel significantly improved shot peening process peening effect produced shot peening intensity high disadvantageous improve sample surface integrity leading reduce fatigue life arc high value optimal shot peening surface quality best depth residual stress precipitation hardening layer reaches numerical calculation useful define process parameters specific residual stress profile intended either quantify benefits specific property like fatigue life help modeling forming process like shot peen forming particular proposed parameter optimization progress shot peening effective control surface texture provide new rules quantitative evaluations shot peening surface modification nak steel
study conducted evaluate continued maintenance efficacy safety therapy switching subcutaneous golimumab glm rheumatoid arthritis patients low disease activity remission previously received tumor necrosis factor tnf inhibitor thirty patients treated etanercept infliximab switched glm maintaining disease activity low level patients divided two groups discussion patient considering general condition convenience low disease activity lda group ldaqw group included patients low disease activity remission switched glm therapy week intervals respectively effects tnf inhibitors glm switch evaluated weeks switching mean das esr das crp values lda groups patients ldaqw groups patients maintained baseline throughout week treatment period das esr remission rates also maintained week baseline remission rate lda ldaqw groups respectively thus glm treatment regimens effective maintaining clinical response achieved lda secondary tnf inhibitors serious adverse events occurred continuation rate weeks groups therapeutic efficacy adequately maintained patients switching tnf inhibitor glm weeks patients receiving tnf inhibitor seamlessly switch glm without serious safety concerns
battery electric vehicles bevs slow diffuse international well swedish market previous studies indicated situational factors economic factors size performance major importance vehicle purchasers choice vehicle paper authors explore consumer centric total cost ownership tco model investigate possible discrepancy purchase price tco internal combustion engine vehicles icevs hybrid electric vehicles hevs bevs creation testing tco model reveals computation could challenging task consumers due bounded access relevant data prediction future conditions application model vehicle sample found bevs could cheaper compared icevs hevs findings paper could prove importance policy marketing alike designing appropriate business models information campaigns based consumer conditions order promoting diffusion bevs society authors published elsevier ltd
bio fuel causes less pollution environment compared diesel fuel however sound vibration resulting combustion bio fuel powered engines adversely affect users study non edible bio fuel calophyllum inophyllum blends investigated performance alternative fuel compared using vibration engine parameter previous studies used overall engine vibration determine optimum bio fuel blends minimal vibration overall vibration could consist vibration components due combustion well external vibration sources condition limits effectiveness identifying optimum fuel blend mainly due vibration caused combustion effect advanced vibration analysis technique consists time domain frequency domain motion visualization analyses operating deflection shape analysis first performed isolate effect external vibration source due torque overall vibration bio fuel powered engines full speed lowest engine torque suitable identification optimum fuel blend minimal engine vibration bio fuel blend least vibration overall root mean square acceleration full speed compared pure diesel bio fuel blends elsevier ltd rights reserved
experiments performed three spring supported separated box girder section models closed wind tunnel investigate vortex induced vibration vtv characteristics particle image velocimetry ply instrument employed obtain flow field around models four viv sensitive velocity intervals observed test model vertical torsional oscillations repeatedly induced comparisons control groups show vortex shedding gap crucial factor induces vivs wake induced vibration wiv observed occur viv gap accompanied dramatic magnification vibrational amplitude wiv becomes weaker disappears wind velocity increases wake vortex shedding mode changes classic mode mode vortex shedding frequency shows special lock mode phase locking found taking vibrating model vortex shedding two coupled oscillators
background previous studies showed associated variety cognitive deficits executive dysfunctions persist even remitted states however role cognitive impairments psychopathology treatment fully understood article aims discuss executive functions central components working memory attention mediate psychopathology considering role dorsolateral prefrontal cortex dlpfc present findings brain stimulation experiment support notion methods effect transcranial direct current stimulation tdcs dlpfc enhancing cognitive control functions investigated twenty four patients experimental group control group received sessions tdcs min consecutive days experimental group received active stimulation control group received sham stimulation participant performance cognitive functions pal srm rvp crt cantab depression scores assessed tdcs results results showed brain stimulation dlpfc improved executive dysfunction patients significant improvement depression scores also observed suggesting cognitive control dysfunction may mediator emotional dysregulation psychopathology limitations follow investigation done study allow infer long term effect tdcs low focality tdcs might stimulated adjacent areas conclusion cognitive components namely cognitive control dysfunction play role psychopathology involved emotion dysregulation amount contribution cognitive components psychopathology however open question tdcs used intervention improve cognitive dysfunction
reductive dehalogenation organic bromides achieved presence riboflavin photocatalyst visible light irradiation specifically benzyl bromide bromoacetophenone quantitatively converted toluene acetophenone respectively using amines electron donors iproh hydrogen donor whereas bromobenzene react thermodynamics reduction radical anion evaluated using redox potentials species involved reaction found thermodynamically exergonic expected occur bromobenzene viability different competing processes timescales corresponding singlet triplet excited states analyzed time resolved techniques quenching amines efficient comparison transient absorption spectra recorded absence presence amines additionally confirmed efficient redox process amines moreover quenched bromides thus deeper understanding overall mechanism photocatalytic reductive reaction achieved key role radical anion photocatalyst demonstrated
elastic modulus circumferential direction carotid artery important evaluate degree arteriosclerosis previous methods utilized magnitude systaltic movement carotid wall estimates elastic modulus magnitude depends elastic modulus surrounding tissues around carotid artery well carotid artery previous methods results overestimates carotid elastic modulus modeled carotid artery surrounding tissues two layered combinational cylinder view point theory strength materials utilizing systaltic movement point surrounding tissues well carotid wall estimate self elastic modulus carotid artery excluding influence surrounding tissues measured carotid elastic modulus vitro animal tensile test results agree vivo estimation
background alkaptonuria aku omim classic mendelian genetic disorder described garrod already causes urine turn black upon exposure air also leads ochronosis well early osteoarthritis main body abstract objective implementation precision medicine approach aku present novel aprecisekure database facilitating collection integration analysis patient data order create aku dedicated ecosystem genetic biochemical clinical resources shared among registered researchers order exploit aprecisekure database developed analytic method based pearson correlation coefficient value generates refreshable correlation matrix complete statistical analysis obtained associating every pair parameters examine dependence multiple variables time short conclusions employing analytic approach showed clinically used biomarkers suitable prognostic biomarkers aku reliable patients clinical monitoring believe database could good starting point creation new clinical management tool aku lead development deeper knowledge network disease advance treatment moreover approach serve personalization model paradigm inborn errors metabolism rare diseases general
paper evaluates progress field ambient intelligence since early days discusses extent earlier visions ambient intelligence materialized arguing large extent already live era ambient intelligence despite true intelligence appears remain elusive examine extent focusing shifting mind sets ambitions researchers last years discuss various reincarnations vision historical societal perspective together critiques leveled many research challenges still remaining open discuss ambient intelligence research aligned contemporary societal needs particularly important create mechanisms enable people interact benefit envisioned technological infrastructure avoiding dangers embedding computational intelligence physical environment brings observing diversification research address different application areas note impetus towards ambient intelligence needs renewed uniting challenge transcends development technological infrastructure
body mass index classification physical activity sedentary behaviors compared adolescents autism spectrum disorder asd typically developing adolescents participants included adolescents asd national survey children health controlling covariates adolescents likely overweight obese less likely engage regular versus typically developing adolescents increased odds overweight obesity attenuated adjustment higher autism severity associated increased odds overweight obesity decreased odds sport club participation findings suggest adolescents asd need targeted programs decrease obesity increase physical activity
objective obesity factor affects response anti tnf drugs however studies patients ankylosing spondylitis rare aimed determine whether obesity affects serum levels adalimumab adl immunogenicity clinical efficacy drug patients methods cross sectional study patients axial receiving adl conducted received dmard per standard care rheumatologist discretion patients body mass index bmi obtained adl treatment began clinical response evaluated using spanish versions basdai index asdas esr index serum concentrations free adl trough level anti adl antibodies measured using promonitor adl promonitor anti adl elisa kits progenika grifols spain prior next subcutaneous injection adl results patients bmi kgl obese opposed bmi normal presented lower blood adl levels increased asdas scores shorter adl treatment time increased basdai results obese patients showed lower probability clinical response adl versus non obese patients regard achieving basdai asdas conclusion patients receiving treatment adl obese significantly lower serum adl levels decreased clinical response without increase immunogenicity
objective effect disease categorized standardized reference system international classification functioning disability health icf objective map effect psoriatic arthritis psa patient perspective icf methods systematic literature review performed qualitative publications reporting domains impact important patients psa identified using following terms psoriatic arthritis quality life impact meaningful concepts extracted publications grouped domains linked icf categories number concepts linked icf category icf level calculated number concepts linkable also calculated results eleven studies articles included analysis twenty five domains impact cited ability work volunteer social participation cited studies total concepts identified could linked different icf categories concepts mostly personal factors could precisely linked represented icf component activities participation rather body structures body functions ten studies reported impairments ability work volunteer social participation reported leisure activities family intimacy pain skin problems body image conclusion psa widely affects aspects patients lives particular aspects related activities participation icf useful approach classification disease effect
background seasonal affective disorder sad characterized recurrent episodes major depression seasonal pattern treated light therapy duration light therapy differs study investigates retrospectively whether single week effective two weeks whether males females respond differently whether effect expectations assessed treatment methods women men received either one week two weeks included three studies patients expectations therapy response assessed results depression severity similar groups treatment decreased significantly treatment main effect time speed therapy response differs significantly treatment duration favor week significant positive correlation expectations therapy response found women rho men rho expectation added covariate repeated measures analysis shows positive effect level expectation speed therapy response limitations limitation retrospective design conclusions difference weeks overall therapy outcome speed therapy response differed week weeks together significant correlation expectations therapy response women hypothesize expectations play role speed therapy response elsevier rights reserved
aim study examine changes sexist attitudes beliefs group spanish adolescents period three consecutive years specific attention paid gender differences participants students mean age first assessment years three years completed ambivalent sexism inventory questionnaire attitudes towards diversity violence longitudinal analysis showed hostile sexism vary time whereas scores benevolent sexism sexist beliefs justification violence fell ages equivalent decrease boys girls boys scored significantly higher girls hostile sexism well sexist beliefs results illustrate sexist attitudes beliefs change adolescence provide confirmation variables show gender differences early age
history application life cycle costing lcc began late state development concept clear literature review presented shows changing approaches lcc drawing four major academic journals peer reviewed papers review verifies revival interest using lcc tandem life cycle methodologies research sustainable building also presents set methods applicable model estimate life cycle costs conventional green buildings objective distinguishing information gathered provides centralized source reference assumptions used lcc calculations concerning key input parameters finding shows increasing trend publications evaluation economic options green building designs performance directions clear concepts methods evolve state help integrate optimize economic social environmental considerations deliver sustainable built environments future
prebiotics functional food ingredients offer potential benefits digestive well particularly circumstances gut compromised antibiotic use exposure pathogens growing body evidence also points towards wider health effects including infant health enhanced mineral absorption weight management prebiotics act stimulating growth activity selected species bacteria large intestine including bifidobacteria lactobacillus much research prebiotics performed inulin oligofructose offer effective route influencing health across lifecycle
context software engineering experienced increased calls attention theory including process theory general theory however process theories potential general theories proposed little empirical evaluation attempted objective purpose paper empirically evaluate two previously untested software development process theories sensemaking coevolution implementation theory sci function behavior structure framework fbs method survey software developers combined four longitudinal positivist case studies achieve simultaneously broad deep empirical evaluation instrument development statistical analysis questionnaire data case data analysis using closed ended priori coding scheme data triangulation described results case data analysis strongly supports sci analysis questionnaire response distributions chi square goodness fit test furthermore case questionnaire triangulation found evidence support sci varied participants gender education experience nationality size nature projects conclusions sci supported evidence fbs subculture found suggests instead iterating weakly coupled phases analysis design coding testing accurate useful conceptualize development hoc oscillation making sense project context sensemaking simultaneously improving mental representations context design space coevolution constructing debugging deploying software artifacts implementation elsevier rights reserved
following concept ubiquity ambient intelligence ami focused technologies approaches development intelligent environments aiming supporting users architectures environments usually modeled multi agent systems facilitating thus investigation various processes enabling environments functionalities scope challenging study decision processes used individual components agents environment mutual cooperation creating decisions ways support particular users activities adequately recent project pies decision processes intelligent environments supported czech scientific foundation period oriented investigation various decision processes could appear various types intelligent environments modeled adequate multi agent architectures paper aims presenting information project goals methodology approaches used well intended used near future special part paper devoted possibilities modeling simulation decision processes using anylogic multimethod simulation tool
background childhood maltreatment important risk factor mental physical health problems adolescents living residential youth care ryc experienced high rate childhood maltreatment high risk group psychiatric disorders quality life qol subjective multidimensional concept goes beyond medical diagnoses lack research regarding associations childhood maltreatment qol present study compare self reported qol adolescents ryc norway without maltreatment histories adolescents general population also study impact number types adversities qol methods adolescents aged years living ryc norway invited participate study participated yielding response rate maltreatment histories assessed interviews trained research assistants completed adolescents previous exposure maltreatment reported adolescents questionnaire measuring health related quality life children adolescents kindl used nonexposed peers ryc sample adolescents general population used comparison general linear model analyses ancova conducted five kindl life domains dependent variables linear regression used study effect number types adversities results exposed adolescents ryc reported poorer qol peers control groups compared nonexposed peers ryc confidence intervals mean score differences kindl subdomains scale physical well emotional well self esteem friends compared general population sample confidence intervals mean score differences physical well emotional well self esteem friends number types adversities associated poorer qol score subdomains physical emotional well self esteem friends school conclusions childhood maltreatment associated poorer qol score suggest use qol maltreatment measures children adolescents ryc
paper conduct theoretical analysis novel computer assisted film television animation design pattern based computer graphics theory three dimensional modeling structure optimization computer graphics rely visualization technology data graphics effectively combined graphic display major direction development computer graphics follow trend analyze issues different perspectives computer graphics applied computer animation success development flight simulator prompted application computer graphics television film advertising industry
ceramides based phytosphingosine sphingosine dihydrosphingosine essential constituents skin lipid barrier protects body excessive water loss roles individual ceramide subclasses regulating skin permeability reasons hydroxylation sphingolipids completely understood investigated chain length dependent effects dihydroceramides sphingosine ceramides unsaturation phytoceramides hydroxyl permeability lipid organization thermotropic behavior model stratum corneum lipid membranes composed ceramide lignoceric acid cholesterol cholesteryl sulfate phytoceramides long acyl chains increased permeability model lipid membranes compared dihydroceramides sphingosine ceramides chain lengths either unsaturation hydroxylation dihydroceramides induced chain length dependent increases membrane permeability infrared spectroscopy showed hydroxylation sphingoid base decreased relative ratio orthorhombic chain packing membrane lowered miscibility phytoceramide lignoceric acid phase separation phytoceramide membranes confirmed ray diffraction contrast phytoceramides formed strong hydrogen bonds highly thermostable domains thus large heterogeneity ceramide structures aggregation mechanisms may confer resistance towards heterogeneous external stressors constantly faced skin barrier elsevier rights reserved
marginalisation people non hegemonic non normative gender roles sexualities often discussed terms silencing silence tends occupy liminal stages communication interaction well suited indexing marginalised subjectivities however paper argues context artistic performance silence displayed rather imposed revalued affirming liberating art thrives equivocality understatement tends silence friendly due affordances relative indeterminacy ambiguity several examples transduction silence modern contemporary art illustrate art embraces rather obscures disavows male female homosexual identities non heroic masculinities works examined include robert rauschenberg agnes martin monochromes new york dada drawings photographs activist hiv aids installations photographs
recently manufacturing industries face various problems shorter product life cycle diversified customer needs situation important reduce lead time manufacturing system constructions manufacturing system implementation stage important make evaluate facility control programs manufacturing cell ladder programs programmable logical controllers plcs rapidly however manufacturing systems implemented methods evaluate facility control programs equipment mixing synchronizing real equipment virtual factory models computers developed difficulty caused complexity manufacturing system composed great variety equipment stopped precise rapid support manufacturing engineering process paper manufacturing engineering environment mee support manufacturing engineering processes using simulation technologies proposed mee consists manufacturing cell simulation environment mcse distributed simulation environment dse mcse consists manufacturing cell simulator soft wiring system emphatically proposed detail mcse realizes making evaluating facility control programs using virtual factory models computers manufacturing systems implemented
context use electronic cigarettes ecs rise high income countries smoking conventional cigarettes known risk factor urologic malignancy incidence progression mortality well urologic health indicators potential impact use urologic health therefore clinical interest urology community objective review available data current use including potential benefits urologic patients potential issues linked toxicology constituents might translate urologic health risks evidence acquisition medline search carried august studies reporting urologic health outcomes use snowballing techniques also used identify relevant studies recent systematic reviews narrative synthesis data around health outcomes toxicology potential use smoking cessation health policy carried evidence synthesis found studies date specifically designed prospectively assess urologic health risks even observational setting generating data would important contribution debate role ecs public health clinical practice evidence recent cochrane review rcts ecs support smoking cessation emerging data indicating potentially harmful components ecs tobacco specific nitrosamines polyaromatic hydrocarbons heavy metals could linked possible urologic health risks conclusions ecs might useful tool encourage cessation conventional cigarette smoking however data collection around specific impact ecs urologic health needed clarify possible patient benefits outcomes adverse events patient summary electronic cigarettes might help people stop smoking overall impact urologic health clear european association urology published elsevier rights reserved
context urban heat island uhi affects biogeochemical cycles human society previous studies uhi indicate urban expansion local land cover change lead higher temperatures cities compared adjacent countryside studies examined joint effects city local scale factors urban warming relative importance objectives examined overall impact urbanization urban warming beijing investigated city size proportion local developed land jointly influenced air temperature quantified relative importance time methods compared temperature trends urban reference stations conducted linear regressions evaluate city local scale influences based meteorological data remote sensing data results urbanization significantly influenced trends air temperature especially summer trends mean temperature caused urbanization degrees decade yearly degrees decade summer increase city size proportion local developed land contributed urban warming relative importance changed time varied seasonally local scale factor played vital role air temperature city size relatively small important summer greenspace local scale however city scale factor may cause stronger heat stress summer less greenspace locally city size large city scale factor became significant factor affecting air temperature conclusion city relatively small optimizing composition configuration local land cover could effectively alleviate uhi effects however city already large effective way control additional sprawl
objective chronic micro aspiration secondary gastroesophageal reflux ger may play role pathogenesis natural history idiopathic pulmonary fibrosis ipf goal investigate relationship chronic anti reflux therapy survival time patients ipf methods case reports comprising data involving gastroesophageal reflux diagnosis treatment analyzed investigate relationship ger related variables survival time identified cohort patients ipf weihai municipal hospital results eligible patients used varying doses chronic anti reflux medications non users chronic anti ger use defined months non prn use antacid drug gastrointestinal motility drugs study entry non users showed months use none chronic symptomatic use anti ger medications significantly associated longer survival time unadjusted analysis adjustment chronic use ger medications independent predictor longer survival time conclusions chronic use anti reflux therapy independent predictor longer survival time patients ipf
new voltage mode bandpass shadow filter presented filter built around current feedback operational amplifier parameters filter controlled adjusting gains external amplifiers built around current feedback operational amplifier contrary conjecture based current mode shadow filter realization summing junction must used summing amplifiers used voltage mode realization experimental results obtained using current feedback operational amplifier presented results obtained confirm functionality proposed circuit
many natural phenomena intuitively represented spatiotemporal data objects moving objects example vehicles rivers hurricanes low pressure systems areas high density foliage etc align well geometric representation change position shape time moving object models exist represent real world objects point line region geometries change continuously time leading research spatiotemporal analysis functionality objects models moving objects ideal representing data streams record motion spatial data time however implementation operations support spatiotemporal analysis moving objects particularly moving regions proven difficult paper develop mechanism support implementation set operations intersection union difference pairs moving regions mechanism builds component model moving regions semantic specifications operations specifically develop generalized method computing intermediate data structure results various operations derived mechanism utilizes well known operational primitives achieves nlgn time complexity using appropriate data structures
introduction sports injuries disorders great impact athletic performance objective develop validate questionnaire pre participation sports identifies athletes risk factors likelihood musculoskeletal injury order select specialized medical evaluation methods used delphi technique gather information reach consensus experts topic found related literature initial version sport readiness questionnaire mir focusing musculoskeletal injuries based researcher experience areas sports orthopedics traumatology medicine exercise sport mes supported theoretical references results pilot phase analysis mir content performed nine specialists mes seven initial questions question removed first round delphi technique experts evaluated six questions mir rounds programmed repeated minimum agreement reached among responses majority specialists question likert type scale ranging round one three questions modified consensus reached concordance index varied reproducibility measure internal consistency mir cronbach alpha satisfactory first round reproducibility phase conclusion present questionnaire proved simple valid tool point view content validity screening athletes probability musculoskeletal injuries referral specialists
background aging process skin shows visible changes characterized loss elasticity appearance wrinkles due reduced collagen production decreased elasticity elastin fibers panax ginseng meyer used traditional medicine various diseases due wide range biological activities including skin protective effects ginsenosides main components responsible biological activities ginseng however protective activities enzymatic preparation red ginseng human skin aging investigated methods efficacy enzyme treated powder complex red ginseng preventing human skin aging evaluated oral administration randomized individuals patients requested take three daily capsules containing either placebo vehicle end testing period skin roughness elasticity skin water content measured results significantly reduced average roughness eye wrinkles global photo damage score compared placebo although significant differences arithmetic roughness average groups addition gross elasticity net elasticity values increased transepidermal water loss level decreased indicating improved skin elasticity moisture content conclusion conclusion enzyme treated red ginseng extract significantly improved eye wrinkle roughness skin elasticity moisture content moreover enzyme treated red ginseng extract would useful substance bio health skin care product copyright korean society ginseng published elsevier
since imitation joint attention important abilities young children since children autism spectrum disorder show range problems domains imitation joint attention important targets intervention study examined possibility promoting imitation joint attention means training programme specifically designed low intensity non residential treatment two matched groups children participated study experimental group receiving training programme improved significantly joint attention group receiving treatment usual experimental group obtained significantly higher imitation score post test compared pre test study shows possible promote joint attention low intensity treatment programme results concerning imitation modest future replications involve measures stability generalization
individuals chronic psychological stress difficult identify clinically often outwardly visible phenotype chronic stress sufficient magnitude impacts reproductive function also concomitantly elicits constellation neuroendocrine changes may accelerate aging general brain aging particular functional hypothalamic amenorrhea phenotypically recognizable form stress due stress induced suppression endogenous gonadotropin releasing hormone secretion reversal functional hypothalamic amenorrhea includes restoration ovulatory ovarian function fertility amelioration hypercortisolism hypothyroidism taken together recovery functional hypothalamic amenorrhea putatively offers neuroprotection ameliorates stress induced premature brain aging possibly syndromic alzheimer disease amenorrhea may viewed sentinel indicator stress hypothalamic hypogonadism less clinically evident men diagnosis difficult establish whether sex differences impact stress brain aging remains better investigated likely low estradiol stress induced anovulation low testosterone stress induced hypogonadism compromise brain health
previously created limited access dual bottle drinking paradigm deliver methylphenidate rats two dosages result pharmacokinetic profile similar patients treated attention deficit hyperactivity disorder chronic treatment resulted altered behavior effects persisting beyond treatment current study adolescent male sprague dawley rats split three groups four weeks age control water low dose high dose briefly low dose high dose consumed first hour hours two eight following three months treatment half rats group group euthanized remaining rats went month abstinence period euthanized vitro receptor autoradiography performed quantify binding levels dopamine transporter dat dopamine type like receptors dopamine type like receptors using win sch spiperone respectively immediately following treatment treated rats increased dat like binding several subregions basal ganglia particularly caudal portions caudate putamen correlated previously reported behavioral changes differences treatment groups measure following abstinence findings suggest chronic treatment clinically relevant high dose results reversible changes dopamine neurochemistry may underlie effects behavior
tropical fruits mango papaya pineapple banana rich sources dietary fibre however studies examined potential physiological effects fibre tropical fruits aim study characterise fermentability dietary fibre found banana papaya pineapple mango estimate physiological effects consuming fruits freeze dried fruit subjected vitro digestion remove digestible carbohydrates digestion residues freeze dried prior fermentation vitro fermentation carried anaerobic conditions simulate conditions large intestine gas volume short chain fatty acids scfas concentration measured scfas analysed gas chromatography gas production time points samples mango fibre resulted gas pineapple papaya banana fibres slurry significantly lower mango fibre compared samples mango fibre resulted significantly propionate compared papaya pineapple fibres butyrate concentrations significantly different total individual scfa production differ among samples fruit fibres fermentable mango fibre rapidly fermented additional work necessary confirm benefit digestive health
hybrid cascade coupled line phaser configuration presented synthesize enhanced group delay responses high resolution radio analog signal processing using exact analytical transfer functions superiority coupled line phasers conventional transversally cascaded section phasers demonstrated verified using full wave simulations wiley periodicals inc
distributed computing achieved tremendous development since cloud computing proposed played vital role promoting rapid growth data collecting analysis models internet things cyber physical systems big data analytics etc hadoop become data convergence platform sensor networks one core components mapreduce facilitates allocating processing mining collected large scale data speculative execution strategies help solve straggler problems however still efficient solution accurate estimation execution time run time tasks affect task allocation distribution mapreduce paper task execution data collected employed estimation two phase regression tpr method proposed predict finishing time task accurately detailed data task drawn interests detailed analysis report made according results prediction accuracy concurrent tasks execution time improved particular regular jobs
objective stimulant treatment improves impulse control among children attention deficit hyperactivity disorder adhd decreased aggression often accompanies stimulant pharmacotherapy suggesting impulsiveness integral aggressive behavior children however children high callous unemotional traits proactive aggression may benefit less adhd pharmacotherapy aggressive behavior seems purposeful deliberate study objective determine whether pretreatment traits proactive aggression affect treatment outcomes among aggressive children adhd receiving stimulant monotherapy method implemented stimulant optimization protocol children years age mean age years male adhd oppositional defiant conduct disorder significant aggressive behavior family focused behavioral intervention provided concurrently primary outcome retrospective modified overt aggression scale antisocial process screening device aggression scale also completed parents measured traits proactive aggression respectively analyses examined moderating effects traits proactive aggression outcomes results children experienced remission aggressive behavior neither traits proactive aggression predicted remission traits odds ratio proactive aggression children whose overall aggression remitted showed decreases traits effect size proactive aggression effect size conclusions findings suggest pretreatment traits proactive aggression forecast worse outcomes aggressive children adhd receiving optimized stimulant pharmacotherapy treatment traits proactive aggression may decline alongside behavioral improvements clinical trial registration information medication strategies treating aggressive behavior youth attention deficit hyperactivity disorder http clinicaltrials gov nct effectiveness combined medication treatment aggression children attention deficit hyperactivity disorder spicy study http clinicaltrials gov nct
approaches detection presymptomatic prodromal alzheimer disease require costly collection analysis biological samples neuroimaging measurements dementia risk assessment dra developed facilitate detection collecting self report proxy report dementia risk variables episodic memory performance free internet website report two validation studies study community residing older adults seeking memory screening senior health fairs tested using mini cog observed taking dra compared demographically matched subsample anonymous internet sample participants seeking memory screening dementia risk factors obtained lower scores dra recognition memory test rmt internet controls addition failed mini cog obtained much lower scores rmt passed mini cog study older adults seeking evaluation cognitive difficulties took dra prior diagnostic evaluations outpatient dementia clinics patients ultimately received diagnosis dementia syndrome scored significantly lower rmt diagnosed conditions deemed normal lower education family history dementia presence hypercholesterolemia diabetes memory test score distinguished dementia dementia groups around accuracy addition score rmt correlated highly scores instruments widely used detect cognitive decline findings support concurrent validity dra detecting prevalent cognitive impairment prospective studies cognitively normal persons subsequently develop dementia necessary establish predictive validity
following collaborative remembering people may adopt partner contributions memory two studies asked people study partially overlapping lists words collaborative remembering dyads either worked include words matter studied limited recall words studied dyad members differential focus source information collaborative recall impacted performance later source memory test nonetheless found frequent source monitoring errors displayed egocentric bias people likely claim partner contributions memories attribute memories partners collaborative remembering people work construct agreed upon version past quickly becomes individual memory society applied research memory cognition published elsevier inc rights reserved
rare case death young man due airway obstruction course angioedema quincke edema type hereditary angioedema due esterase inhibitor deficiency diagnosed man alive information concerning man health state given public prosecutor decision ordering medico legal autopsy extremely helpful recognizing cause death elsevier ireland ltd rights reserved
study presents results geogrid pullout tests conducted wet fine grained soils failures reinforced soil structures often involved inadequate drainage due use fine grained soils led stringent specifications backfill material structures although significant economic reasons relieving specifications one approach improve issue reinforce fine grained soils geosynthetic providing reinforcement lateral drainage although using reinforcement plane drainage capability conceptually promising transmissivity requirements application properly evaluated pullout tests conducted cohesive soils using geogrids tensile strength without plane drainage channels results indicate geogrids plane drainage layers show higher pullout resistance conventional geogrids finding contributes promoting use poorly draining soils backfill material
objective investigate whether excessive television viewing throughout childhood adolescence associated increased antisocial behavior early adulthood methods assessed birth cohort individuals born dunedin new zealand regular intervals birth age years used regression analysis investigate associations television viewing hours ages years criminal convictions violent convictions diagnosis antisocial personality disorder aggressive personality traits early adulthood results young adults spent time watching television childhood adolescence significantly likely criminal conviction diagnosis antisocial personality disorder aggressive personality traits compared viewed less television associations statistically significant controlling sex socioeconomic status previous antisocial behavior parental control associations similar sexes indicating relationship television viewing antisocial behavior similar male female viewers conclusions excessive television viewing childhood adolescence associated increased antisocial behavior early adulthood findings consistent causal association support american academy pediatrics recommendation children watch hours television day pediatrics
research field eating disorders limited middle east aim present study profile lebanese outpatients mixed method design used clinicians across lebanon filled individual questionnaires outpatients participated focus groups results showed bulimia nervosa prevalent followed anorexia nervosa binge eating emerging socio demographic profile lebanese patient single female young adult middle high socio economic status severe symptoms amenorrhea multiple purging behaviors depression also general delay seeking help made patient recovery difficult present study emphasizes critical need public health approach awareness could help developing preventive remedial educational programs targeting youth lebanon middle east
multi channel mixed signal full customized cmos integrated biopotential sensor chip microcontroller based electronic system developed vitro extracellular recording neural signals multi site planar microelectrode array sensors simultaneous neural signal recording designed prototyped chip fully integrated analog signal processing circuitry control system biosensor system built hierarchical modules incorporate microelectrode electrophysiological sensors analog signal buffers configured two stage amplifier gain providing amplifiers based operational transconductance amplifier ota capacitive feedback digital logic interface units including clock generation time division multiplexing control circuitry prototype fabricated mosis using ami double poly triple metal layer cmos technology electroless gold plating process used replace aluminum material obtained standard cmos process biocompatible metal gold planar microelectrode array sensors prevent cell poisoning undesirable electrochemical corrosion post cmos processing packaging techniques applied biosensor chip promotes biocompatibility stability aqueous cell culture environment microcontroller based electronic system interfacing biosensor client post processing action potential signals sensed biopotential sensor chip also developed biosensor tested electrically presence electrolyte environment shown provide satisfactory signal noise ratio neural signals amplitudes range frequencies range khz biological example vitro recordings conducted neurons aplysia californica shown research work proves full functionality neural recording biosensor chip incorporated interfacing electronic system based bit motorola coldfire mcf risc processor chip amplification time division multiplexing techniques multi channel biosensor chip allow large scale simultaneous recording biological activities neurons
paper describes development two wheeled self balancing robot kinematic analysis system architecture consists two axial wheeled rectangular structure powered pair motors two separate motor drivers controlled pulse width modulated voltage signals received arduino microcontroller board attitude determination robotic platform accomplished imu sensor combination accelerometer rate gyro mechanical system design velocity decomposition two wheels robot body analyzed establish kinematic model model local position robot mapped according global coordinates finally kinematic constraints established fixed standard wheels two wheeled robot
paper presents atlas distributed computing system allows collaboration internet browsers allows users donate wasted processing power internet connected machines help researchers companies compute difficult tasks platform aims maintaining similar speeds available cloud computing services running tasks lower cost order atlas minimizes amount time needed per computation intelligently distributes jobs utilizing user browsing patterns benchmarks demonstrate atlas may viable alternative existing platforms
given initial assignment processes machines machine reassignment problem find assignment improves machine usage subject several resource allocation constraints considering reassignment costs propose heuristic based simulated annealing solving problem uses two neighborhoods one moves process one machine another second one swaps two processes different machines present data structures permit validate execute move time number resources number dependencies service process belongs heuristic runs two different sets parameters parallel convergence criterion satisfied machine reassignment problem subject roadef euro challenge proposed algorithm ranked fourth final round senior category competition
mothers fathers siblings multiplex mothers fathers siblings simplex mothers fathers siblings autism spectrum disorder families assessed using broader phenotype autism symptom scale mothers fathers siblings showed social interest expressive use nonverbal communication compared mothers fathers siblings conversational skills also improved fathers siblings compared fathers siblings siblings showed significantly lower rigidity intense interests compared siblings decreased number intensity broader autism phenotype traits observed parents siblings within simplex families provide behavioral evidence consistent findings increased novo genetic events simplex families
objective examine emotion processing euthymic bipolar patients ebp compared healthy controls addition determine whether association emotion processing psychosocial functioning material methods sample ebp healthy controls matched age gender education level premorbid intelligence studied subjects assessed using matrics consensus cognitive battery mccb two additional executive function measures trail making test part stroop test emotion processing examined using mayer salovey caruso emotional intelligence test msceit psychosocial functioning assessed using functional assessment short test fast results euthymic bipolar patients obtained lower scores controls msceit measures except using emotions branch likewise ebp obtained worse performance healthy controls neurocognitive domains correlation msceit strategic area measures fast total score found regression analysis showed residual depressive symptomatology explains variance functional outcome msceit strategic area score explained additional neurocognition increase percentage variance explained emotion processing conclusions euthymic bipolar patients exhibit deficits emotion processing emotion processing associated social functioning patients
difficulty emotion regulation hallmark feature patients borderline personality disorder bpd skills training concepts based dialectical behaviour therapy dbt common effective treatment options specifically addressing lacking skills emotion regulation however far unclear aspects coping change course dbt skills training coping strategies predict symptom change present process outcome analysis based randomized controlled study aims investigating questions referring general conception coping using observer rated approach assess coping strategies directly therapy sessions total patients bpd underwent two individual clinical interview assessments pre post study intervention half patients underwent dbt skills training half wait list control individual assessment sessions transcribed analysed using coping action pattern rating scale outcome assessed pre post intervention using outcome questionnaire borderline symptom list results showed increase overall coping functioning patients underwent dbt skills training compared controls specific increases relatedness coping stress appraised challenge along specific decreases autonomy coping stress appraised threat changes predicted changes general distress borderline symptomatology results interpreted within general framework aiming understanding psychological effects treatments bpd particular effects related coping effective emotion regulation strategies may therefore important candidates potential change mechanisms treatments bpd copyright john wiley sons ltd
cooperative organizational climate often argued promote knowledge sharing behaviors among employees however research indicates managerial interventions aimed shaping organizational climate difficult execute develop test contingency model intrinsic motivation job autonomy moderators relationship find social climate cooperation better predicts knowledge sharing employees show low levels intrinsic motivation high levels job autonomy suggests cooperative climate intrinsic motivation substitutes respect impact knowledge sharing behaviors climate job autonomy complements find support ideas data gathered sample employees knowledge intensive firm elsevier ltd rights reserved
environmental applications graphene limited occurrence aggregation herein graphene oxide synthesized reduced ascorbic acid intercalated cetyltrimethylammonium bromide ctab ctab characterized boehm titration adsorption desorption fourier transform infrared spectroscopy raman spectroscopy fluorescence spectrophotometry ray diffraction scanning electron microscopy ctab used adsorptive removal acid red acid orange dyes water batch column operation batch operation effect adsorbent dosage initial dye concentration contact time temperature dyes adsorption assessed adsorption isotherms kinetics thermodynamics analyzed systematically regarding fixed bed operation effect bed height flow rate studied experimental results fitted thomas bdst models bed loss capacity along five adsorption regeneration cycles determined order approach practical application ctab wastewater treatment namely removal dyes elsevier inc rights reserved
comprehensive evaluation university cultural soft power manufacturing engineering made seen soft power university culture development depth understanding article used fuzzy comprehensive evaluation method establish university cultural soft power evaluation model comprehensive evaluation university cultural soft power based four core aspect decisive soft power key soft power basic soft strength
wavelet analysis applied detect greatest deviation perfect circle roundness cylindricalness shaft like components virtual manufacturing engineering based concepts roundness cylindricalness least square method adopted determination reference least square circle deviation calculated order obtain extremum errors wavelet transform carried binary wavelet time domain frequency domain virtual probe used signals measured point using wtnode gettranslation function accuracy measurement depends large extent length individual step along axis density measured points sections experiments shown measuring processing time saving results wavelet analysis much reliable
technical note first present adaptive distributed observer discrete time leader system adaptive distributed observer provide follower estimation leader signal also estimation leader system matrix based estimation matrix devise discrete adaptive algorithm calculate solution regulator equations associated follower obtain estimated feedforward control gain finally solve cooperative output regulation problem discrete time linear multi agent systems state feedback output feedback adaptive distributed control laws utilizing adaptive distributed observer
implication neuroinflammation schizophrenia sustained recent genetic evidence represents one exciting topics schizophrenia research drugs inhibit microglia activation especially classical tetracycline antibiotic minocycline currently investigation alternative antipsychotics however recent studies demonstrated microglia activation hallmark neuroinflammation plays important roles brain development inhibition microglia activation minocycline shown induce extensive neuronal cell death impair subventricular zone svz neurogenesis synaptic pruning early postnatal adolescent rodent brain respectively deleterious effects contrast neuroprotective actions minocycline adult stages potential importance schizophrenia since minocycline triggers similar pro apoptotic effects developing brain nmda receptor nmdar antagonists known induce long term schizophrenia like abnormalities moreover altered postnatal neurogenesis recently described human striatum proposed induce striatal dopamine dysregulation associated schizophrenia finally effect minocycline synapse remodeling interest considering recently reported strong genetic association pruning regulating complement factor gene schizophrenia raises exciting possibility conditions hyperactive synaptic pruning supposed schizophrenia inhibitory action minocycline turns beneficial effect relevance early therapeutic interventions altogether data support differential view microglia activation inhibition studies needed clarify relevance results pathogenesis schizophrenia use minocycline antipsychotic drug
developed experiment help students understand basic regulation postabsorptive postprandial glucose metabolism availability energy sources physical activity fed fasted state within practical session teams two three students subject investigators performed one three different trials inactive subjects ingested glucose solution water rested seated position end trial prior activity subject performed min walking glucose ingestion subsequent resting phase postactivity subject ingested glucose solution walked min rested afterwards glucose levels drawn trials fasting value immediately glucose ingestion min min thereafter students analyzed glucose values worked tasks students evaluated usefulness experiment students found experiment useful enable gain understanding learning objectives clarify items indicated experiment necessary enable understand learning objectives experiment necessary helpful check learned found experiment necessary present article shows great value experiments within practical courses help students gain knowledge energy metabolism using active learning strategy students outworked complex physiological tasks improved beneficial communication interaction students different skill sets problem solving strategies
purpose study aims classify schools based traffic pollutants complex sources assess environment determine state allergic diseases among students using international study asthma allergies children isaac questionnaire assess connection air pollutants materials methods total seven schools divided three categories according characteristics surrounding environments three schools traffic related zones two schools complex source zones urban two schools complex source zones industrial complex isaac questionnaires administered completed questionnaires analyzed results frequency asthma treatment past months showed significant increase exposure confidence intervals cis complex source zones frequency allergic rhinitis treatment past months increased significantly exposure black carbon cis cis cis subjects conclusion terms supporting children health care prevention related major spaces children school zones spaces used coming leaving school playgrounds classrooms essential ensuring safety children traffic accidents also protection local traffic pollutants various hazardous environmental factors
work presents intelligent trading architecture ita new automated trading system architecture supports multiple strategies multiple market conditions hierarchical trading signals generation central idea proposed system architecture decomposing trading problem set tasks handled distributed autonomous agents minimal central coordination kind architecture take advantage currently available future high performance computing systems systems due way computer architecture evolved recent past foreseeable future composed multiple processor cores implementing ita software architecture employing carnegie mellon navigation carmen robot control software using publish subscribe communication model together carmen communication model allow implementation high performance scalable parallel computing systems leverage architecture multi core systems work evaluated data structures algorithms employed symbol module ita software architecture responsible maintaining synchronized local copies exchanges limit order books lob instruments traded system lob implementation strongly outperformed reference implementation evaluated parameters one order magnitude cases achieving average throughputs million orders creating new orders million orders changing existing orders million orders querying orders copyright john wiley sons ltd
paget disease bone chronic metabolic bone disorder characterized increased bone resorption new bone formation aim study defining role inhibitors canonical wnt catenin signaling pathway patients paget disease bone scarce contrasting results reported literature studied patients females males radiological scintigraphic evidence paget disease bone healthy subjects matched age sex propeptide type collagen terminal telopeptide type collagen sclerostin dickkopf related protein dkk evaluated blood samples laboratory expected mean serum levels bone turnover markers propeptide type collagen terminal telopeptide type collagen significantly higher paget disease bone group compared control group difference observed groups dickkopf sclerostin dickkopf sclerostin never correlated bone turnover markers sclerostin positively correlated age conclusion results suggest regulators wnt beta catenin pathway altered patients paget disease bone positive correlation found sclerostin age paget disease bone patients indicates comparative studies sclerostin serum levels must adjusted age
purpose study investigate types childhood abuse sample inmates explore relationships childhood abuse criminality drug addiction overall sample inmates came risky families high prevalence crime drug addiction mental health problems results showed history child abuse common emotional neglect prevalent physical emotional sexual abuse odds childhood abuse higher among inmates whose fathers addicted drugs involved crime whose siblings suffered mental health problems
taiwan teaching focuses around lecturing students little opportunity interact problem based learning pbl means instruction students learn subject active participants pedagogical process emphasis problem solving study authors investigated whether pbl would enhance self efficacy better common lecturing children little access technology outside school two sixth grade computer classes students located mountainous regions eastern taiwan served participants quasi experimental non equivalent control group design used one class utilizing pbl principles used traditional lecturing pre posttest administered using general self efficacy scale data analysis employing mann whitney test pearson goodness fit results indicated pbl superior lecturing respect increase computer self efficacy
recent advances simulation quench cold work machining processes large aluminum forgings opening way new paradigm design manufacture sustainment aircraft structures use large forgings permits unitization smaller parts brackets fittings lugs etc primary structural components like spars bulkheads done order reduce part count turn leads significant reductions manufacturing cost unitization also translate weight reduction avoidance comparing built structure raises number issues structural durability damage tolerance notably reduced repair replace capability reduced crack arrest capability viability unitization concept dependent availability material systems retain mechanical properties thick sections also designer ability retain durability damage tolerance understand mitigate effects residual stresses recently next generation design approach directly addresses issues developed deployed among things new approach requires extraction residual stress effects material property data explicit introduction effects selected critical regions structure paper provide overview emerging application icme design large aluminum forgings aircraft primary structure concomitant development verification validation methodologies
background sports related injuries adolescents incur significant amount hospital resources sports related injuries uncommon cause visit however national estimates injuries teenagers unknown objectives aim study identify characterize emergency department visits result sports related injuries among teenagers across united states study describes outcomes associated sports related injuries necessitating visits among teenagers national level study design descriptive epidemiology study methods nationwide emergency department sample data set largest payer health care database united states used identify visits external cause injury related sports occurring patients aged years outcomes examined included discharge status visit presence concomitant injuries descriptive statistics used summarize estimates nationwide representative estimates computed using discharge weight variable results visits ages years experienced sports related injuries total charges close million mean total per visit charge male patients accounted total visits frequently occurring injuries superficial injury contusion visits sprains strains fracture upper limb open wounds head neck trunk well intracranial injury close visits occurred among residing geographical areas median household income levels greater visit admitted hospital mean length stay days mean hospital charge visit inpatient services male patients composed hospitalizations total hospitalization charges across entire united states million conclusions sports injuries account substantial number teenage visits united states patient hospital level characteristics analyzed highlighted
paper describes design verification phase lock loop pll components within framework front end digital satellite radio diversity reception first functionality implemented pll described block diagram second individual pll components presented analysed altogether voltage controlled oscillator vco automatic amplitude control aac buffer stage tscp logic well dcvsl high speed two divider multi modulus divider mmd phase frequency detector developed frequency tuning range pll ghz hence vco tuning range around ghz beyond vco post layout phase noise dbc mhz nominal environmental conditions post layout yield analysis predicts additionally vco aac connected due additional aac feedback circuit current consumption well vco output amplitude decrease overall system simulation shows settling process pll tri state five state mode pfd finally vco performance compared state art vcos
cannabis sativa cannabaease currently widely used illicit drug around world psychoactive chemical plant tetrahydrocannabinol thc federal government united states well countries classified thc schedule controlled substance concerning use cannabinoids therapeutic agents exhibits beneficial therapeutic effects nausea vomiting cancer aids patients cannabis decreased intensity spasm tremors multiple sclerotic patients hand chronic use cannabis sativa may cause severe unwanted acute chronic side effects cognition coordination learning defects impairment memory among users addiction possible suicidal attempts still cannabis may trigger acute cardiovascular diseases including mortality although progress introducing new agents work like thc sativex nabilone conador agents await extensive development enhance efficacy decrease toxicity conclusion outcome medical use cannabis blurred presence recreational use question whether legalized still needs extensive discussion
degree isohydric anisohydric behaviour extends water balance developing fruits previously explored examine water relations hydraulic behaviour vitis vinifera berries development two contrasting cultivars display isohydric grenache anisohydric shiraz behaviour hydraulic resistance normalised berry surface area grenache clusters significantly lower constant development whereas shiraz increased lower rachis hydraulic resistance grenache compared shiraz inversely related xylem vessel diameter berry transpiration xylem water uptake measured detached berries decreased alike development veraison detached berries cultivars showed transition net imbalance xylem water uptake transpiration shiraz showing larger imbalance berry dehydration towards end ripening planta imbalance must counterbalanced larger phloem water influx post veraison berries concurrently calculated pressure gradients xylem water uptake showed decline broadly agreed measured values higher suction xylem water uptake pre veraison berries mainly generated transpiration conclude isohydric anisohydric behaviour reflected contrasting behaviour fruit hydraulics change xylem water uptake phloem import correlated loss propensity generate negative apoplastic pressure berry
article argue social psychological research implicit racial associations relatively unconscious associations based race fruitful area explore greater understanding racial bias affects children schools highlight key insights research implicit racial associations implications education identify areas research implicit racial associations education calling collaboration scholars racial inequality education scholars implicit racial associations research likely provide productive new perspective understanding teachers school personnel engage behaviors reproduce racial inequality often spite best intentions commitments racial equity
cos pvcl copolymer synthesized infiltrated caco particles prepare thermosensitive porous microgels exhibited phase transition behavior temperature similar lower critical solution temperature lcst copolymer incorporation microgel cotton done pad dry cure method aqueous microparticle dispersion contained citric acid crosslinking agent vitro drug release experiments performed two different temperatures degrees pbs study drug release behavior response temperature due shrinkage microgels drug release profiles obtained found enhanced release aloin temperature lcst release conditions microgel loaded fabrics proved vivo biocompatible skin irritation studies displayed obviously high water vapor permeability degrees mtt assay showed obvious cytotoxicity microgel loaded cotton mouse fibroblast cells within days results obtained demonstrated potential use thermos responsive microgel loaded cotton fabrics textile based drug delivery system treating sunburn skin care elsevier rights reserved
among processes micropart manufacturing special attention paid applying electrochemical ecmm electrodischarge edmm micromachining processes especially predicted sculptured surface tools microforming processes manufacturing first part paper review comparison ecmm edmm presented special focus accuracy productivity additionally solutions integration electrochemical electrodischarge machining reviewed analysis background concept combining ecmm edmm edmm sequential process carried machine tool combination gives possibility minimizing disadvantages emphasizing advantages ecmm edmm processes considerations carried based literature review second part paper overviews special edmm machine design cad cam support examples applying edmm sequence presented elsevier inc rights reserved
testosterone deficiency highly prevalent men metabolic syndrome type diabetes mellitus low testosterone levels men appear independent cardiovascular risk factor predictor subsequent development metabolic syndrome reciprocally metabolic syndrome leads decrease testosterone levels review provides account pathophysiological mechanisms bidirectional relationship hypogonadism body composition inflammation insulin sensitivity well effects testosterone replacement diverse metabolic parameters
female ring tailed lemurs lemur cotta malagasy primates size monomorphic males socially dominate males exhibit long pendulous clitoris channeled urethra masculine traits evoke certain attributes female spotted hyenas crocuta crocuta draw attention potential role androgens lemur sexual differentiation hormonal correlates prenatal development assessed explore possibility maternal androgens may shape masculine morphological behavioral features developing female lemurs maternal serum alpha hydroxyprogesterone dehydroepiandrosterone sulphate dhea androstenedione androst ene dione testosterone beta estradiol charted throughout pregnancies ring tailed lemurs spotted hyenas lemur pregnancies associated immediate increase androgen concentrations implicating early maternal derivation followed continued increases across stages gestation pregnancies produced singleton males twin males mixed sex twins marked greater androgen estrogen concentrations pregnancies produced singleton twin females especially third trimester implicating fetal testes late term steroid profiles concentrations dhea mostly detectable limits suggesting minor role adrenals androgen biosynthesis androgen concentrations pregnant lemurs bearing female fetuses although less pregnant hyenas exceeded preconception postpartum values peaked third trimester although maternal occasion fraternal source androgen may exist fetal lemurs research required confirm steroids would reach developing female contribute masculinization elsevier inc rights reserved
objective aim study summarize interactions hepatitis virus hcv infection iron overload understand mechanisms iron overload chronic hepatitis chc role iron plays hcv life cycle data sources review based data articles published pubmed databases january keywords hepatitis virus iron overload iron metabolism hepcidin translation replication study selection articles related iron metabolism iron overload patients chc effects iron hcv life cycle selected review results iron overload common patients chc mechanisms involve decreased hepcidin levels caused hcv signal transducer activator transcription mitogen activated protein kinase bone morphogenetic protein smad signaling pathways altered expression iron metabolism related genes studies found iron increases hcv replication studies found opposite result studies suggest positive role iron hcv translation mechanisms involve increased expression levels factors associated hcv internal ribosome entry site dependent translation eukaryotic initiation factor protein conclusion growing literature demonstrates chc leads iron overload iron affects hcv life cycle turn research conducted clarify mechanism involved complicated interaction iron hcv
study type fuzzy chance constrained programming tfcp method developed supporting energy systems planning esp uncertainty tfcp incorporates chance constrained programming within type fuzzy programming framework handle uncertainties type fuzzy sets probabilistic distributions objective constraints well examine reliability satisfying risk violating system constraints tfcp based energy system tfcp model formulated energy systems planning shanghai multi energy resources multi processing technologies multi conversion technologies multi end users considered solutions energy supply electricity generation capacity expansion air pollutant emission associated different constraint violation risks obtained results reveal natural gas one major energy supply sources city future increasing city electricity generation structure tends transition coal dominated clean energy dominated natural gas onshore wind offshore wind photovoltaic power iii city energy supply security enhanced provoking utilization renewable energies increasing results helpful managers adjust city current energy structure enhance energy supply security well make tradeoff system cost constraint violation risk elsevier ltd rights reserved
purpose review food allergies fas growing epidemic western countries poorly defined etiology defined adverse immune response common food allergens fas present heterogeneously single multiorgan response ranges severity localized hives angioedema systemic anaphylaxis recent findings current research focusing epithelial derived cytokines contends temporal regulation factors impact initial sensitization persistence responses upon repeated food allergen exposure mechanistic understanding draws insight myriad atopic conditions studied humans modeled mice summary review highlight epithelial derived cytokines initiate potentiate fas also review existing evidence contribution atopic diseases pathogenesis whether symptoms overlap atopic diseases
social dominance orientation sdo theorized stable early emerging trait influencing outgroup evaluations view supported evidence cross sectional two wave longitudinal research yet limitations identifying causal paths cross sectional two wave designs increasingly acknowledged article presents first use multi wave data test time relationship sdo outgroup affect among young people use cross lagged latent growth modeling lgm three wave data set employing norwegian adolescents years five wave data set american university students years overall sdo exhibits high temporal rank order stability predicts changes outgroup affect research represents strongest test date sdo role stable trait influences development prejudice highlighting lgm valuable tool social political psychology
study methodologies useful support assembly parts challenging engineering task benefit recent innovations computer graphics visualization technologies paper presents proposal innovative methodology based virtual augmented reality useful support components assembly herein introduced strategy based upon four stages procedure first designer conceives assembly sequence using cad system visualizing scene wearing immersive virtual reality device second stage sequence developed experienced user using equipment differences two assembly sequences recorded exploited detect critical points assembly sequence develop knowledge based system finally virtual user manual produced augmented reality final user uses tool position object assemble detected tracking finger position user series symbols writings added external scene help end user assembly procedure test case based assembly scale model developed evaluate methodology evaluation process procedure seems feasible presents advantages state art methodologies proposed literature
hippocampus innervated aminobutyric acid gaba projection neurons nucleus incertus including population expressing neuropeptide relaxin rln studies aimed gaining understanding role rln signaling hippocampus via protein coupled receptor rxfp examined distribution rln immunoreactive nerve fibres rxfp mrna positive neurons relation hippocampal gaba neuron populations rln positive elements detected close apposition substantial population somatostatin sst gaba immunoreactive neurons smaller population parvalbumin calretinin immunoreactive neurons different hippocampal areas consistent relative distribution patterns rxfp mrna marker transcripts light functional importance dentate gyrus hilus learning memory anatomical data examined possible influence rln rxfp signaling region spatial memory using viral based cre loxp recombination methods adult mice floxed rxfp gene deleted rxfp hilar neurons assessed spatial memory performance affective behaviors following infusions aav cre ires egfp vector cre expression observed hilar neurons including sst positive cells situ hybridization histochemistry rxfp mrna confirmed receptor depletion relative levels floxed rxfp mice infused aav egfp control vector rxfp depletion within hilus impaired spatial reference memory appetitive maze task reflected reduced percentage correct choices increased time meet criteria relative control continuous spontaneous alternation maze task rxfp depleted mice made fewer alternations first minute suggesting impairment spatial working memory however rxfp depleted control mice displayed similar locomotor activity anxiety like behavior light dark box elevated plus maze tests learning long term memory retention morris water maze data indicate endogenous rln rxfp signaling modulate hippocampal dependent spatial reference working memory via effects sst interneurons knowledge hippocampal cognitive processing wiley periodicals inc
apache hadoop widely used distributed computing framework file system hadoop distributed file system hdfs assumes datanodes system homogeneous nature cloud system scales datanodes likely become heterogeneous thus extensive research placed improving performance heterogeneous hadoop systems little attention placed security improvements motivates investigate data allocation scheme called secure hdfs sechdfs integrating secret sharing technique improve storage security heterogeneous hadoop system datanodes hadoop system classified variety different types groups based vulnerability characteristics sechdfs addresses increased risk issue caused data replication hdfs allocating fragments file many different types datanodes possible multiple replicas fragment datanodes type storage assurance model developed evaluate quality security offered sechdfs analysis assurance model performance evaluation experiments show sechdfs impact performance hadoop system much comparison default hdfs significantly improving data assurance heterogeneous environment
jute geotextile jgt gradually finding increasing acceptability among geotechnical engineers primarily response growing global emphasis ecoconcordance jgt concomitant benefits like facility production tailor made fabrics price competitiveness made best natural choice different civil engineering constructions natural geotextile jgt experimented across world bioengineering measure river bank erosion control results encouraging conventional methods river bank protection erosion prone stretches indian rivers proved highly expensive proposition respect capital investment recurring maintenance costs reason department jute fibre technology university calcutta india collaboration national jute board ministry textiles government india alongwith irrigation waterways department government west bengal india embarked upon designing engineering jgt per site specific requirement river west bengal portraying main theme article
objective observe investigate cause prevention measures sport specific training track field athletes ankle joint injury thus provide scientific basis sports injury prevention treatment methods randomly selected track field athletes school grade total using statistical methods track field athlete injury occurrence analyzed results investigation analysis total athletes sports injury incidence sports injury injury something age sports life athletes statistically significant difference part sports injuries mainly ankle thigh muscle respectively body fatigue poor physical quality technical master major cause injuries skilled conclusion order reduce sports injuries enhance life movement athletes sports ability process athletes training exercise future pay special attention prolong athletes preparing activities improve standardization action reduce technical error correct planning exercise
context hiv considerable debate role schools teachers potential sources care support vulnerable children qualitative research examines care experienced practiced pupils teachers rural western kenya primary secondary schools interviews conducted teachers orphaned vulnerable pupils alongside photovoice drawing thematic analysis ethic care theoretical perspective unpack informal caring practices teachers within resource constrained settings research provides glimpses schools spaces care participation support orphaned vulnerable pupils recognising providing institutional support development ethic care schools may help tackle considerable educational barriers facing girls boys orphaned vulnerable move care closer towards centre educational policy practice global south
security important problem wireless sensor networks intrusion detection system one common methods network security people shown solicitude paper dynamic random password authentication drpa method proposed identity authentication communication nodes detect prevent malicious behavior stage network operation paper introduces method automatic generation random passwords user wants communicate password verified confirm whether normal user malicious user passwords generation verification process suitable wireless sensor networks using simulation experiments carried results show method superior methods
seepage plays important role soil erosion contour ridge systems seepage generated subsurface flow causes hillslope instability reducing soil shear strength mobilizing soil particles produce cavelike features called seepage undercuts lead contour failure main threat contour plowing seepage results large amounts soil erosion due row grade models used predict seepage time series provide basis modeling soil erosion resulting seepage contour ridging systems understanding seepage effects advance knowledge regarding seepage erosion mechanisms contour ridge systems study treatments arranged using orthogonal rotatable central composite design model seepage time series build simple seepage prediction model investigate effects row grade field slope ridge height seepage discharge seepage discharge time series followed shaped curve seepage discharge processes fit exponential model determination coefficients greater furthermore physical meaning exponential model consistent experimental results seepage discharge continuously increased inflection point decreased finally seepage discharge approached steady value maximum seepage discharge growth rate achieved within min seepage discharge became steady within min second order polynomial regression models used determine total predicted steady seepage discharge using independent variables row grade field slope ridge height produced values respectively ridge height row grade significantly affected total predicted steady seepage discharge field slope related factors ignored significant effects seepage discharge effects row grade resulted concave curve increasing factor value ridge height exerted positive linear effect seepage discharge elsevier rights reserved
accessible mind maps tools due visual nature hardly available available focus rendering structure considering nonverbal communication elements ongoing discussions paper describe need type communication well mind map tool capable processing respective information coming leap tracking system attached interactive surface
familiarising researchers practitioners different countries policies police interviews children contributes exchange knowledge strengthens global approaches child abuse start describing system videotaped testimonies cyprus first years system implementation continue effects tourism police interviews children police forces destinations high tourist numbers need comprehend tourist seasons could influence police interviews children studies investigated whether children tourists testified police departments holidays explored tourist seasons affected number testimonies obtained cyprus police forces taking account presence non cypriot non native speaking children number testimonies taken languages greek presence translators interviews analysed national sample police interviews children period decade using official police records copies transcripts children testimonies expected results revealed significant differences police interviews children tourist seasons show slight increase number interviews non cypriot children tourist seasons copyright john wiley sons ltd
wireless sensor actuators networks wsans constitute one challenging technologies tremendous socio economic impact next decade functionally energy optimized hardware systems development tools maybe critical facet technology achievement prospects especially area agriculture hostile operating environment comes add general technological technical issues reliable robust wsan systems mandatory paper focuses hardware design architectures wsans real world agricultural applications presents available alternatives hardware design identifies difficulties problems real life implementations paper introduces sensotube new wsan hardware architecture proposed solution various existing design constraints wsans establishment proposed architecture based firstly abstraction approach functional requirements context secondly standardization subsystems connectivity order allow open expandable flexible reconfigurable energy optimized reliable robust hardware system sensotube implementation reference model together encapsulation design installation analyzed presented details furthermore proof concept certain use cases studied order demonstrate benefits migrating existing designs based available open source hardware platforms sensotube architecture
paper networked routers decision support tables presented big data structures routing tables ease modeling interconnected networks traffic update costs grown size presenting multitude possibilities communication infrastructures created complexity reached volume processing tends efficiently administered new protocols development real time session transmissions still lacks fault tolerance aspects contribution article proposes solution existent resources networking equipment used implement fault tolerance making effective use vast searchable environment solution comes view realtime session persistent routing problem context analyzed depth interacting components
background aggressive behaviors common pediatric age counseling parents one main preventive therapeutic starategies study aimed assess relationship frequency aggressive behaviors life satisfaction self rated health srh counseling family members friends representative sample iranian children adolescents materials methods nationwide study school students aged years selected cluster stratified multi stage sampling method provinces iran world health organization global school based health survey questionnaire gshs used mental disorders assessed gshs questionnaire consisted worthless angriness anxiety insomnia confusion depression worried results overall students girls mean standard deviation age years participated study prevalence physical fight victim bully lower children adolescents consulted father compared consult physical fight bully less prevalent children adolescents consulted mother friends compared consult also prevalence srh good also lower children adolescents share problem father mother compared consult conclusion counseling family members associated low physical fight low bully good sexual reproductive health srh children adolescents encouraged consult parents problems
amount data collected different real world applications increasing rapidly volume data large loaded memory may impossible analyze using single computer although efforts taken manage big data using single computer problem may solved acceptable time frame making parallel computing indispensable way handle big data paper investigate approaches attribute reduction parallel using dominance based neighborhood rough sets dnrs take consideration partial orders among numerical categorical attribute values utilized multicriteria decision making method first present properties attribute reduction dnrs investigate principles parallel attribute reduction dnrs parallelization different components attribute reduction explored detail furthermore parallel attribute reduction algorithms dnrs proposed experimental results uci data big data show proposed parallel algorithm effective efficient elsevier inc rights reserved
software inspection models remarkable development past four decades particularly field automatic inspection software codes electronic sessions small number improvements made field system analysis design amount using formal inspection model based single check lists physical electronic sessions shows decrease interest inspection system analysis phase man cantered issue inspectors support using electronic tools lead higher efficiency inspection process paper proposes comprehensive web based tool aimed accelerating inspection process early phases software development order evaluate efficiency proposed tool two case studies conducted inspect artifacts six software projects two software companies comparing statistics related defects detected using tool detected using formal method shows efficiency used tool
software startups newly created companies operating history oriented towards producing cutting edge products however despite increasing importance startups economy scientific studies attempt address software engineering issues especially early stage startups anything startups need engineering practices level better larger companies time resources scarce one failed project put business study aim improve understanding software development strategies employed startups performed state practice investigation using grounded theory approach packaged results greenfield startup model gsm explains priority startups release product quickly possible strategy allows startups verify product market fit adjust product trajectory according early collected user feedback need shorten time market speeding development low precision engineering activities counterbalanced need restructure product targeting growth resulting implications gsm outline challenges gaps pointing opportunities future research develop validate engineering practices startup context
analysis several algorithms data structures framed peeling process random graph vertices degree less adjacent edges removed vertices degree less left often question whether remaining graph core empty settings may possible remove either vertices edges graph peeling cost example hashing applications keys correspond edges buckets vertices one might use additional side data structure commonly referred stash separately handle keys order avoid collisions natural question cases find minimum number edges vertices need stashed order realize empty core show problems complete sole exception edge variant stashing solvable polynomial time standard uniform graphs elsevier rights reserved
link educational attainment future health wellness well understood little investigation considered potential impacts distinct forms childhood maltreatment high school completion present study relationship five categories childhood maltreatment physical emotional sexual abuse physical emotional neglect completion high school education examined using childhood trauma questionnaire ctq september may data collected risk youth study arys cohort street involved young people use illicit drugs vancouver canada used logistic regression examine relationship childhood maltreatment high school completion controlling range potential confounding variables specifically five separate models category maltreatment two combined models employed examine relative associations cumulative impact different forms childhood maltreatment educational attainment among young people reported completing high school separate multivariable analyses physical abuse emotional abuse physical neglect emotional neglect remained positively independently associated incomplete high school education combined multivariable model forms childhood maltreatment considered together emotional abuse adjusted odds ratio confidence interval form maltreatment remained significantly associated incomplete high school education cumulative impact assessment indicated moderate dose dependent trend greater number different forms childhood maltreatment greater risk completing high school education findings point need trauma informed interventions improve educational attainment among vulnerable young people well evidence based prevention programmes nurse family partnership aimed supporting risk families maltreatment occurs
stochastic model nonisothermal creep long term strength metallic materials proposed experimental data creep zhskp alloy temperatures equal degrees stochastically analyzed experimental data used substantiate hypotheses applied constructing model stochastic model checked adequacy experimental data creep zhskp alloy stationary nonstationary loading conditions shown calculated experimental data satisfactory agreement
turn self organizing map som oriented scalable map map generalizing neighborhood function winner selection homogeneous gaussian neighborhood function replaced matrix exponential thus specify orientation either map space data space moreover associate map global scale locality winner selection model suited number graphical applications texture image synthesis surface parameterization solid texture synthesis map generic versatile task specific algorithms applications work reveals overlooked strength soms processing images geometries elsevier ltd rights reserved
system design development fundamental capabilities engineer department control engineering national institute technology nara college offering course called practical system design unique opportunity students experience entire process developing autonomous mobile robot fourth year students years however recent years robot design construction become huge challenge students address problem worked improving engineering program first introduced problem based learning pbl education program experimental engineering classes years also require students submit written report class session report intended help improve students schedule management role sharing work tracking skills reports reviewed relevant course teachers assessed logic quantitative representation paper discuss approach achievements future subjects taken multi stage experience educational program especially effect report writing
obese patients likely osteoarthritis total knee arthroplasty tka investigation sought evaluate physical function activity level quality life qol obese participants near year postsurgical follow appointment recruited evaluation included qol activity questionnaire medical histories anthropometrics strength aerobic capacity sixty participants completed assessments obese tka patients physical performance limitations low physical activity levels year surgery completion postoperative rehabilitation
brief practical power optimization method calculates optimal power supply body bias voltages given target operational frequency temperature proposed evaluated proposed optimization method based upon simple power model several coefficients leakage power switching power temperature operational frequency obtained accurate real chip measurements calculated optimal voltage settings proposed model achieve minimum accuracies room temperature degrees degrees respectively since proposed methodology based well known power formulas applied latest soi technologies
objective purpose study determine whether digital breast tomosynthesis dbt cost effective alternative full field digital mammography ffdm medicare privately insured patients undergoing screening mammography materials methods retrospective data analysis performed july july data women presenting screening mammography included additional radiologic workup patients chose undergo dbt ffdm basis personal preference physician suggestion cost difference summation findings year period used calculate recall rates cancer detection rates billing costs regional private insurer medicare results data patients participated divided patients underwent dbt underwent ffdm year screening private insurance billing cost million medicare cost million screening follow imaging radiologic procedures per person costs approximately higher dbt group using forms insurance however cost per cancer detected lower dbt group private governmental insurance leading potentially million saved per cancers found standardization difference cancer detection rates two groups dbt cost equivalent alternative ffdm private insurance billing cost inefficient alternative respect medicare costs conclusion community based setting dbt cost equivalent potentially cost effective alternative ffdm capacity improving cancer detection recall rates
aging associated progressive loss costimulatory molecule lymphocytes null cells accompanied acquisition new biological functional properties give rise impaired immune response regulatory mechanisms govern appearance function cell subset aging several associated inflammatory disorders remain controversial present whole genome dna methylation gene expression profiles null cells counterpart comparative analysis revealed genes differentially methylated two cell subsets total genes associated cytotoxicity grzb tyrobp runx cytokine chemokine signaling cxcr demethylated null cells novo methylated genes matched defects tcr signaling pathway itk txk cdg lck tcr landscape analysis confirmed null cells oligo monoclonal expansion polyclonal background cells feature family repertoire specific individual reported null cells show preactivation state characterized higher level expression inflammasome related genes leads release activated overall results demonstrate null cells unique dna methylation landscape associated differences gene expression contributing functionality cells understanding epigenetic regulatory mechanisms could suggest novel therapeutic strategies prevent accumulation activation cells aging
two ring signature schemes number theory research unit ntru lattices presented first scheme constructed random oracle model extension ducas lyubashevsky prest identity based encryption scheme ntru lattices asiacrypt moreover motivated boyen lattice mixing vanishing trapdoors pkc second scheme standard model achieved chosen message attack new constructions proved strongly existentially unforgeable security reduced hardness ntru lattices compared existing lattice based ring signatures schemes efficient shorter signature length copyright john wiley sons ltd
power systems need sufficient generation capacity support demand times addition dispatchable generation resources capable adjusting power output short term basis alleviate uncertainties nondispatchable generation load fluctuations also correct forecast errors paper presents long term planning approach optimize capacities energy storages fast ramping generation model integrate capability storage provide multiple services system formulation takes account wind generation demand forecast errors well short term fluctuations stochastic optimization problem formulated consisting hourly intrahour time scales approach determines optimal size newly deployed generation storage resources provide adequate generation capacity ramping needed support hourly demand additionally method ensures system capable following net load intrahour time intervals well mitigating impact short term wind power load fluctuations formulation power balance network security system ramping capability stochastic constraints modeled chance constraints bus ieee bus test systems studied show effectiveness proposed approach
ordered fept copt collectively called review become potential materials future ultrahigh density perpendicular magnetic recording pmr media due high magnetocrystalline anisotropy rendering small grains high thermal stability however pmr media using high anisotropy faces well known trilemma issues among thermal stability signal noise ratio snr writability paper provide overview impact overcoming superparamagnetic limit balancing trilemma issues ultrahigh density pmr media research development materials presented perspectives enhancing thermal stability snr writability furthermore provide combined approaches tackle challenges balancing trilemma issues focusing materials engineering
little known whether stereotypes influence social judgments autistic individuals particular compete tacit face face cues compared impression formation subjects high functioning autism hfa age gender matched controls information profession job applicant served stereotype activating information target person nonverbal behavior presented computer animation showing two virtual characters interaction contrary hypothesis hfa participants sensitive nonverbal cues controls moreover hfa showed tendency evaluate persons positively might indicate routine hfa apply impression formation order compensate deficit intuitive understanding nonverbal communication cues
adsorption widely used technique removal dyes wastewaters variety adsorbents work main focus potential assessment anion exchange membrane removal different dyes using batch system investigation experimental data applying various kinetic thermodynamic models removal anionic dyes eosin eriochrome black congo red anion exchange membrane bii aqueous solution carried effect various parameters contact time membrane dosage temperature ionic strength percentage removal anionic dyes studied experimental data assessed kinetic models namely pseudo first order pseudo second order elovich liquid film diffusion bangham modified freundlich models equation used analyze experimental data results indicate adsorption anionic dyes bii follows pseudo second order kinetics maximum values regression coefficient systems adsorption dyes suitable controlled liquid film diffusion mechanism adsorptive removal dye eosin eriochrome black decreased temperature thermodynamic parameters free energy delta degrees enthalpy delta degrees entropy delta degrees adsorption dyes membrane bii calculated values enthalpy entropy negative ebt representing adsorption dyes bii physiosorptive exothermic nature whereas positive values enthalpy entropy adsorption bii indicating adsorption endothermic spontaneous nature evident study anion exchange membrane shown good potential removal dyes aqueous solution used adsorbent dues removal commercial levels
development new sensor systems able detect identify find position targets equipped stealth technology began early sensor systems utilise acoustic magnetic seismic physical effects target activity reason motivating development new sensor systems based radar optical principal operation detecting targets systems usually emit electromagnetic energy operation thanks passive principle provide users advantages hidden positioning difficult discovery reconnaissance tools therefore new ugs systems also allow detecting low flying targets helicopters propeller jet aircraft etc detection range several kilometres information flight direction usually estimated deduced spatiotemporal sequence detections multiple interlinked ugs systems submitted paper analyses low flying target position finding principle time direction arrival tdoa basis presents qualities found ugs arrangement topologies characteristics unambiguous position determination low flying targets also contains mathematical description signal digital processing intended find low flying target position processed results presented table diagram forms created matlab mathematical environment presented detection identification results obtained real recorded signals
huaihe river sea entering channel strategic backbone project expands huaihe river flood way improves hongze lake flood control standard ensures safety people arable land environmental impact assessment system carried engineering construction three simultaneous management system simultaneous design construction use taken environmental protection optimal scheme confirmed early planning stage construction stage environmental protection problems managed strictly construction management department construction units supervising unit trial operation phase levee beach farmland ecological environment restored soil conservation measures implemented land utilization controlled strictly using non cultivated land accounting less fertile farmland resettlement yuan invested recently huaihe river sea entering channel project yuan accounting total investment invested environmental protection project passed water acceptance put use may passed final acceptance construction project discharged experience two huaihe river flood plays key role valley security regional development project novel architectural style beautiful environment convenient transportation becoming water conservancy tourism projects consisted engineering landscape natural scenery garden art popular science training entertainment according purpose green water conservancy ecological water conservancy construction operation management
composite materials fine structure development high cost complex moreover developing traditional method time consuming laborious costly difficult obtain accurate systematic scientific conclusions application finite element analysis software ansys optimized composite design performance analysis strength materials bearing damage computer simulation process obtaina range experiment information substantial cost savings shorten development cycle paper properties sic whisker reinforced polymer composites researched whisker aspect ratio volume ratio interfacial bonding status meaning finite element software results show aspect ratio interface volume ratio whisker increased load transfer distance increased time andthe whisker could bear axial stress matrix aspect ratio increased shearing stress interface reduced however interface volume ratio increased shearing stress interface increased impact interfacial bonding status whiskers bear axial stress much larger one resin matrix
paper investigates development mild hybrid powertrain system integration conventional manual transmission equipped powertrain secondary power source form electric motor driving transmission output shaft primary goal paper study performance partial power gear shifts implementation torque hole filling electric motor gear changes achieve goal mathematical models conventional mild hybrid powertrain developed used compare system dynamic performance two systems mathematical modelling used run different simulations gearshift control algorithm design system development allowing evaluate achievable performance dependency system properties impact motor power degree torque hole compensation also investigated keeping mind practical limits motor specification investigation uses output torque vehicle speed well vibration dose value evaluate quality gearshifts different motor sizes results demonstrate torque hole may eliminated using motor power however minimum vibration dose value gear change achieved using peak power elsevier ltd rights reserved
purpose evacuation drills realistic interactive focusing situational audio visual realities scenario based interactivity authors developed game based evacuation drill gbed system presents augmented reality materials tablet computers paper current research purpose improve visual reality materials gbed system design methodology approach author approach develop new gbed system superimposes digital objects three dimensional computer graphics dcg elements onto real time vision using marker based library binocular opaque head mounted display hmd current easily available technologies findings findings trial experiment new gbed system improve visual reality appropriate disaster education however problems remain practical use research limitations implications using gbed system participants hmd wearers suffer sickness difficulty moving important safety problems hmd based systems social implications combination hmds gbeds integrating virtual real worlds raise questions merits pros cons originality value originality research combination hmd gbed previously realized primarily simulation games virtual worlds authors believe research potential expand disaster education
amazon cloud becoming available viable platform parallel computing earth system models increasingly interested leveraging capabilities towards improving climate projections particular faced long wait periods high end clusters elasticity cloud presents unique opportunity potentially infinite availability small sized clusters running high performance instances among specific applications new paradigm show uncertainty quantification climate projections polar ice sheets antarctica greenland significantly accelerated using cloud indeed small sized clusters efficient delivering sensitivity sampling analysis core tools uncertainty quantification demonstrate approach used carry extensive analysis ice flow projections one largest basins greenland north east greenland glacier using ice sheet system model public domain nasa funded ice flow modeling software show errors projections accurately quantified using monte carlo sampling analysis cloud judicious mix high end parallel computing cloud use best leverage existing infrastructures significantly accelerate delivery potentially ground breaking climate projections particular enable uncertainty quantification previously impossible achieve elsevier ltd rights reserved
students education conducted chair process control engineering rwth aachen university involves two elements lecture laboratory course due continuously rising number students resulting variety students technical backgrounds longer possible offer laboratory sessions registered students result established framework allows students experiment using theoretical principles lecture without participate laboratory courses means framework cover whole range different aspects involving planning engineering plant means piping instrumentation diagrams physical simulation eventual implementation automation application framework concept originally part blended learning project represents teaching program well aligns blended learning approach supported rwth aachen university ifac international federation automatic control hosting elsevier ltd rights reserved
neural cell adhesion molecule ncam shown obligate regulator synaptic stability pruning critical periods cortical maturation however functional consequences ncam deletion organization inhibitory circuits cortex known vesicular gamma amino butyric acid gaba transporter vgat channelrhodopsin chr enhanced yellow fluorescent protein eyfp transgenic mice ncam expressed postnatally perisomatic synaptic puncta eyfp labeled parvalbumin somatostatin calretinin positive interneurons neuropil anterior cingulate cortex acc investigate ncam deletion affects spatial organization inhibitory inputs pyramidal cells used laser scanning photostimulation brain slices vgat chr eyfp transgenic mice crossed either ncam null wild type mice laser scanning photostimulation revealed ncam deletion increased strength close inhibitory connections layer pyramidal cells acc addition ncam null mice intrinsic excitability pyramidal cells increased whereas intrinsic excitability gabaergic interneurons change increase inhibitory tone onto pyramidal cells increased pyramidal cell excitability ncam null mice alter delicate coordination excitation inhibition coordination acc may factor contributing circuit dysfunction diseases schizophrenia bipolar disorder ncam implicated
article provides enriched technology acceptance model explaining impact classic additional variables software engineering tools acceptance within information systems development courses two novel domain specific variables identified professional training diffusion model interchange statistical verification proposed model study regarding influence variables students intention use specific tools conductedproviding users enhanced means selecting optimal software real life projects
background cimicifuga racemosa one herbs used treatment climacteric syndrome cited alternative therapy estrogen apart hectic fevers dyspareunia dry mouth also increase significantly menopause yet reported whether racemosa impact sublingual gland may relate dry mouth attempt determine compared effects estrogen racemosa sublingual gland ovariectomized rats results staining showed acinar cell area contracted intercellular spaces broadened ovx ovariectomized rats group treatment estradiol icr isopropanolic extract racemosa improved lesions transmission electron microscopy showed rough endoplasmic reticulum expansion mucous serous acinar epithelial cells apoptotic cells commonly seen ovx group sham sham operated rats group mitochondria plasma membrane infolding lesions striated ducts also observed lesions alleviated treatments note ovx icr group volume mitochondria striated duct larger groups immunohistochemical staining showed ratio caspase positive cells significantly increased acinar cells ovx group compared sham group mean absorbance caspase striated ducts also increased estradiol decreased ratio caspase positive cells caspase striated ducts significantly icr also reduced ratio caspase positive cells striated ducts reduction striated ducts inferior ovx group conclusion estradiol icr inhibit subcellular structural damage regulate expression caspase caused ovariectomy effects identical suggesting drugs confer protective effect sublingual gland ovariectomized rats specific location mechanism action producing effects different
pulmonary vein isolation point point radiofre quency catheter ablation constitutes cornerstone catheter ablation strategies treatment atrial fibrillation however despite advances pulmonary vein isolation ablation strategies long term success rates ablation remain suboptimal highlights need develop techniques achieve durable lesions strategies proposed improve durability pulmonary vein isolation divided two groups addressed improving quality lesion optimize detection acute reconnection ablation procedure manuscript reviews role potential benefits techniques according current clinical evidence
gap storing data relational databases transferring data form xml closed sql xml queries generate xml data relational data sources however relational database systems support evaluation sql xml queries even systems supporting sql xml evaluation queries quite slow compared evaluation sql queries paper present scx approach allows efficiently evaluate sql xml queries relational database system matter whether supports sql xml result sql xml query scx supports different output formats ranging plain xml different compressed xml representations including succinct encoding xml data schema aware compressed xml grammar compressed xml many cases scx produces compressed xml result sql xml query even faster evaluation sql xml queries non compressed xml provided oracle furthermore approach query evaluation scales better larger dataset faster approach compared sql xml query evaluation oracle elsevier ltd rights reserved
purpose pulmonary embolism serious preventable disease requires urgent care recent years several reports media basketball players experiencing aim present study assess whether need depth studies determine whether basketball players constitute group particularly risk describe hypotheses investigated methods reviewed original articles among professional amateur basketball players scientific literature pubmed internet google search seasons included used search strategies included combination related terms rates calculated compared obtained studies results cases detected majority men mean ages among males among females focused six cases detected among national basketball association asociacion clubes baloncesto basketball players resulting average incidence cases per players per year national basketball association asociacion clubes baloncesto respectively incidence much higher observed general population studies age group conclusions basketball players seem higher risk peers general population studies needed confirm findings identify factors predisposing contribute prevention
paper multi objective framework proposed daily operation smart grid high penetration sensitive loads virtual power player vpp manages day ahead energy resource scheduling smart grid considering intensive use distributed generation vehicle grid maintaining highly reliable power sensitive loads work considers high penetration sensitive loads loads industrial processes require high power quality high reliability interruptions weighted sum approach used distributed parallel computing techniques efficiently solve multi objective problem two stage optimization method proposed using particle swarm optimization pso deterministic technique based mixed integer linear programming milp realistic mathematical formulation considering electric network constraints day ahead scheduling model described execution time large scale problem reduced using parallel distributed computing platform pareto front algorithm applied determine set non dominated solutions maximization minimum available reserve incorporated mathematical formulation addition cost minimization take account reliability requirements sensitive vulnerable loads case study bus distribution network fleet gridable electric vehicles evs used illustrate performance proposed method execution time solve optimization problem reduced using distributed computing elsevier ltd rights reserved
objective study characterization fretting fatigue strength hydrogen gas environment test materials low alloy steel scmh super alloy two kinds austenitic stainless steels sus susl test performed hydrogen gas mpa absolute pressure purity hydrogen gas fretting fatigue limit defined fretting fatigue strength million cycles materials fretting fatigue strength hydrogen gas environment increased short life region however fretting fatigue strength hydrogen gas environment decreased long life region exceeding million cycles except scmh reduction fretting fatigue strength air million cycles reduction rate sus susl tangential force coefficient hydrogen gas environment increased compared air estimated increase one causes reduced fretting fatigue strength found hydrogen gas environment order discuss extension fretting fatigue life hydrogen gas observed stress level fretting fatigue limit air continuous measurement fretting fatigue crack propagation performed hydrogen gas environment using direct current potential drop method result found extension fretting fatigue life caused delay start stable crack propagation elsevier ltd rights reserved
community driven question answering platforms gaining popularity days number posts platforms increasing tremendously thus challenge keep platforms noise free attracting interest research community stack overflow one popular computer programming related platform established users stack overflow learnt acceptable format scope questions due course even questions get closed aware required edits therefore chances questions reopened increases hand non established users adapted stack overflow system find difficulty editing closed questions work aim identify features help differentiate editing approaches established non established users motivate need recommendation model recommendation model assist every user edit closed questions leveraging edit style established users platform
birth piglet immune system immature dependent upon passive maternal protection weaning piglet mucosal immune system develops first weeks reached maturity weaning ages common commercial farms weaning piglets presented vast diverse range microbial dietary environmental antigens ability distinguish antigens mount protective response potential pathogens develop tolerance dietary antigens critical survival failure reflected high incidence morbidity mortality post weaning period growing recognition widespread use antibiotics control infection critical period controlled led detailed studies factors drive development mucosal immune system role gut microbiota driving process origin bacteria colonise young piglet intestine impact rearing environment review briefly describes mucosal immune system equipped respond appropriately antigenic challenge programmed sequence develops results studies critical interplay host immune system gut microbiota discussed along effects rearing environment comparing results human studies development allergies children approach promote earlier maturation piglet immune system resist challenges weaning outlined
validation database mining methodology goes evaluation process benchmarks availability essential paper aim randomly generate relational database benchmarks allow check probabilistic dependencies among attributes particularly interested probabilistic relational models prms latter extend bayesian networks bns relational data mining context enable effective robust reasoning relational data structures even though panoply works focused separately bayesian networks relational databases random generation work identified prms track paper provides algorithmic approach allowing generate random prms scratch cover absence generation process proposed method allows generate prms well synthetic relational data randomly generated relational schema random set probabilistic dependencies interest machine learning researchers evaluate proposals common framework databases designers evaluate effectiveness components database management system
electrohydraulic shaking table essential experimental facility many industrial applications real time simulate actual vibration situations including structural vibration earthquake however still challenging area acceleration waveform replication acceleration output responses electrohydraulic shaking table would intended magnitude phase acceleration closed loop system due inherent hydraulic nonlinear dynamics electrohydraulic servo systems thus accurately coordinately control parallel hydraulic actuators electrohydraulic shaking table critical issue many control techniques developed address issue currently used key techniques field reviewed article objectives academic investigations industrial applications article reviews new control algorithms electrohydraulic shaking table obtain high fidelity acceleration waveform replication accuracy
networked controlled system illustrate paradigm robust mean field games modeling framework interface differential game theory mathematical physics infinity optimal control tries capture mutual influence crowd individuals first establish mean field system games including effects adversarial disturbances second identify optimal response individuals given population behavior third provide analysis equilibria stability
chrysosporium species saprophytic filamentous fungi commonly found soil dung animal fur subcutaneous infection caused organism rare humans report case subcutaneous fungal infection caused chrysosporium keratinophilum year old woman patient presented severe chromoblastomycosis like lesions left side jaw neck years also got tinea corporis trunk since years old chrysosporium keratinophilum isolated tissue neck scales trunk respectively patient showed satisfactory response itraconazole therapy although discontinued follow
functional limitation often complained patients ankylosing spondylitis rising number patients suffering limited number reports focusing functional limitation chinese patients study conducted investigate level functional limitation explore associations demographic disease related factors total outpatients recruited cross sectional study tertiary general hospital southwest china functional limitation measured bath ankylosing spondylitis functional index basfi data collected following questionnaires bath ankylosing spondylitis disease activity index basdai bath ankylosing spondylitis patient global score bas pittsburgh sleep quality index questionnaire psqi finally outpatients completed survey median basfi worse function limitation found outpatients extra spinal manifestation older age lower household income back pain higher disease activity morning stiffness poorer sleep worse patient well multivariate regression analysis indicated patient well disease activity disease duration positive predictors functional limitation outpatients southwest china mild level functional limitation factors associated functional limitation included disease duration disease activity patients well taken consideration assessing functional limitation outpatients besides comprehensive targeted interventions conducted patients early possible effective improve functional outcome
materials engineering often faced necessity display shape morphology studied surfaces essential surface evaluation various components well new materials research several imaging techniques available purposes one appropriate laser scanning confocal microscopy magnification range technique satisfies needs researchers working limits conventional optical microscopes scanning electron microscopes overcomes limitations optical microscopy better lateral resolution ability control depth field possibility high resolution imaging relatively thick samples compared advanced expensive scanning electron microscopes laser scanning confocal microscopy special requirement sample preparation also need measure vacuum particular examples laser scanning confocal microscopy beneficial use presented paper scratch track evaluation diamonds tip control tyvek structure examination measurement surface characteristics wire saw cut glass reported
chitosan reacted tannic acid obtain three modified chitosan biopolymer chemical structures characterized ftir elemental analysis prepared biopolymers used adsorb iii metal ions industrial wastewater factors affecting adsorption process biosorbent amount initial concentration metal ion medium adsorption efficiency increased considerably increase biosorbent amount medium adsorption process biosorbent different metal ions fitted freundlich adsorption model adsorption kinetics followed pseudo second order kinetic model adsorption process occurred according diffusion mechanism confirmed interparticle diffusion model modified biopolymers efficient biosorbents removal iii metal ions medium elsevier rights reserved
organ donation neither enrich donors impose financial burdens described scope health care required living kidney donors reflecting contemporary understanding long term donor health outcomes proposed approach identify donor health conditions covered within framework financial neutrality proposed strategies pay care despite affordable care act united states donors continue inadequate coverage important health conditions donation related may compromise postdonation kidney function amendment medicare regulations needed clarify surveillance treatment conditions may compromise postdonation kidney function following donor nephrectomy covered without expense donor countries lacking health insurance residents sufficient data exist allow creation compensation fund donor insurance policies ensure appropriate care providing coverage donation related sequelae well care preserve postdonation kidney function ensures protection financial burdens health care encountered donors throughout lives providing coverage care thus cost effective even without considering health care cost savings occur living donor transplant recipients authors advance practical approach provide health care coverage donation related sequelae well care preserve postdonation kidney function without creating inducement donation review country specific considerations implementation including amendments medicare policy united states
child labour affects children health mentally physically various psychosocial effects children involved labour range loneliness depression severe developmental mood disorders strengths difficulties questionnaire used gauge extent involved child labour affects mental health sample children taken research study child labourers school going child labourers school going non labourers mental health measured along dimensions questionnaire used child labour school going child labour school going non labour three categories whose mental health explored using screening instrument scoring data put statistical analysis found child labour led higher behavioral difficulties found child labourers undergo higher level overall stress compared school going child labourers school going non labourers also found case dimension emotional distress thus child labour effect mental health large extent tells child labour serious problem evidence affects child mental health focus mental well child especially working children providing safe stimulating environment child important giving ability integrate mainstream society dignity deserve possible children grow mentally healthy adults
purpose tobacco nicotine dependence significant heritable component genome wide association studies associated single nucleotide polymorphisms snps nicotine dependence western european populations examined whether snps influence nicotine dependence successful treatment tobacco dependence czech middle european population materials methods variants analysed pcr rflp taqman assay adult heavy tobacco dependent smokers patients centre treatment tobacco dependence prague well self reported non smokers results discussion except association tobacco dependence confirmed genetic variants agreement previous studies strongest determinant tobacco dependence allele carriers comparison contrast none analysed variants reached significance respect year course successful tobacco dependence treatment subset patients conclusion confirmed association variants within genes code nicotinic acetylcholine receptors cypa tobacco dependence development czech population success tobacco dependence treatment influenced analysed snps published elsevier
male infertility multifactorial disorder impressively genetic basis besides sperm abnormalities cause numerous cases male infertility study evaluated genetic variants exons intron exon boundaries rablb gene infertile men oligoasthenoteratozoospermia oat immotile short tail sperm ists defects define association variants human male infertility purpose dna extracted peripheral blood pcr reaction sequencing results sequenced segments analyzed present study infertile men ists defect oligoasthenoteratozoospermic infertile men recruited men iranian origin took years collect patient samples ists defect result delc intronic variant identified five patients oligoasthenoteratozoospermia defect one patient ists defect heterozygote form variant identified controls allelic frequency delc variant significantly statistically higher oligoasthenoteratozoospermic infertile men bioinformatics studies suggested delc allele would modify splicing rablb pre mrna addition identified new genetic variant rablb gene according present study delc allele rablb gene could risk factor iranian infertile men oligoasthenoteratozoospermia defect genetic studies required understand accurate role variant pathogenesis human male infertility
develop evolutionary fuzzy proportional integral derivative pid controller permanent magnet synchronous motor pmsm first consider fuzzy pid control design problem based common control engineering knowledge good transient performances obtained increasing gains decreasing gain transient error big give evolutionary algorithm autotune control parameters fuzzy pid controller implement proposed based fuzzy pid control controller real time texas instruments tmsf floating point dsp also give simulation experimental results show effectiveness proposed intelligent digital control system abrupt load torque variation using prototype pmsm
assessment basic way evaluate improve teaching traditional assessment method usually single classroom examination conducive improvement students comprehensive quality order realize cultivation various abilities students reformed teaching assessment methods metal cutting machine design course project teaching model course constructed based cdio teaching idea content project implement virtual simulation design machine tool transmission system project experiment attendance classroom comprehensive performance small test homework included course evaluation index system practice shows teaching reform effect obvious students active learning ability training achieved
transparent low resistive contacts critical efficient solar energy harvesting devices important reconsider material choices electrode design devices move films nanostructures paper study effectiveness indium tin oxide ito metals contacts systems although ito studied extensively developed effective transparent contact devices results show effectiveness translate systems particularly consideration resistance requirement nanowires metal shells contacts enable better absorption within semiconductor compared ito furthermore strong dependence contact performance semiconductor band gap diameter nanowires found metal contacts outperform ito nanowire devices regardless sheet resistance constraint regime diameters less band gaps greater metal shells optimized best absorption significantly thinner ito enables design devices high nanowire number density consequently higher device efficiencies
lifecycle structural health monitoring shm systems provide abundance information greatly beneficial securing structural safety whole service life application large scale structures management accumulated massive data sophisticated long term shm system poses challenge robust data management system dms facilitates spatiotemporal data management also enables display attractive way highly desirable article presents development effective visualized dms specific managing immense heterogeneous shm data integrating nested relational database three dimensional model virtual reality technology demonstrates application instrumented supertall structure custom nested data model designed store redundant inherent temporal data hierarchical inherent spatial data strategies speeding querying massive data set database making use openscenegraph osg engine model reconstructed spatial data serves platform data visualization four dimensional animation protocol presented tying temporal data construction schedule model efficiency proposed dms exemplified application supertall structure instrumented sophisticated long term shm system american society civil engineers
additive manufacturing referred printing henceforth applied creation static structures severely restricts scope printing techniques sure printing build structures many different materials including plastics metals ceramics severely nevertheless monolithic structures rule day prospect printed multi material structures still research problem paper look expanding capabilities printing manufacturing full mechatronic systems specifically electric motor supporting electronics taken preliminary steps towards goal presented fully successful demonstrate additive manufacturing constitutes universal constructor von neumann sense
aspect ratio plot strongly influence perception trends data arc length based aspect ratio selection demonstrated many empirical advantages previous methods however still clear method works paper attempt unravel mystery exploring mathematical foundation first explain rationale method parameterization invariant follow rationale extend previous methods parameterization invariant propose maximizing weighted local curvature mlc parameterization invariant form local orientation resolution lor reveal theoretical connection average slope resultant vector furthermore establish mathematical connection banking degrees derive upper lower bounds average absolute slopes finally conduct quantitative comparison revises understanding aspect ratio selection methods three aspects showing awo always perform similarly demonstrating advantages robustness providing counterexample previous methods produce poor results mlc works well
methacholine challenge tests used measure changes pulmonary function indicate symptoms asthma addition pulmonary function tests measure global changes pulmonary function computed tomography images taken full inspiration administration methacholine provide local air volume changes hyper inflation post methacholine individual acinar units indicating local airway hyperresponsiveness acini may extreme air volume changes relative global average indicating hyperresponsiveness extreme values may occur clusters propose gaussian mixture model spatial smoothness penalty improve prediction hyperresponsive locations occur spatial clusters simulation study provides evidence spatial smoothness penalty improves prediction different data generating mechanisms apply method computed tomography data seoul national university hospital five healthy ten asthmatic subjects copyright john wiley sons ltd
based experimental data scaled model liede bridge guangzhou china nonlinear behavior self anchored suspension bridge process structural system transformation systematically comprehensively studied variation main cable deformation hanger tension main girder stress transformation process analyzed relationships different states structural system studied characteristics distribution patterns lateral torsional angle spatial cable clamps identified paper principles two stages construction control self anchored suspension bridges introduced construction control targets error elimination methods stage also discussed based measured results situ static load test response characteristics main cable axial deformation hanger tension deflection stress main girder described unfavorable unbalanced loading case effects induced secondary dead live load obtained linear analysis procedure according accumulative theory american society civil engineers
objective investigate prevalence thyroid dysfunction autoimmunity tai determine age specific reference ranges individuals year old furthermore investigated impact age specific reference ranges prevalence thyroid dysfunction design retrospective analysis laboratory data collected six months mainly individuals consulting outpatient clinic method data individuals withheld applied strict exclusion criteria avoid confounders exclusion individuals tai tpo abs kiu outliers data individuals used determine age specific reference ranges prevalence subclinical hypothyroidism sch subclinical hyperthyroidism sch determined according reference ranges commercial assay also according calculated age specific reference ranges study population results individuals included year old prevalence sch tai comparable groups respectively prevalence sch significantly higher individuals years compared individuals years calculated percentile age specific tsh range miu individuals years prevalence sch sch determined basis age specific reference ranges prevalence sch significantly decreased individuals years became comparable individuals years conclusions prevalence sch higher individuals years compared individuals years age specific tsh reference ranges used comparable study groups order avoid misclassification older individuals important use age specific reference ranges daily clinical practice elsevier rights reserved
temporal graphs represent vertices binary relations change along time work paper proposes represent temporal graphs cells binary matrix two dimensions represent extreme vertices edge two dimensions represent temporal interval edge exists strategy generalizes idea adjacency matrix storing static graphs proposed structure called compressed capable dealing unclustered data good use space uses asymptotically space worst case lower bound storing cells binary matrix without considering regularity techniques group leaves buckets compress nodes children show improve performance time space experimental evaluation compares dimensional extension date compressed data structures based inverted indexes showing potential use different types temporal graphs
century evolution research relating public health general occupational risks particular largely dominated industrial needs strategies play role financing studies carried also design thus feeding uncertainty dangers exist one main issues underlying uncertainty relates invisibility work related diseases particular occupational cancers based multidisciplinary surveys social sciences life sciences challenge dominant monocausal model understanding links cancer risk factors first part article demonstrates reductive interpretation cause cancer perpetuates uncertainty inscribed paradigm doubt hindering knowledge recognition occupational cancers two case studies french mining sector illustrate danger clearly identified carcinogens always called question rights recognition occupational diseases denied workers suffer maintaining invisibility hence paradigm doubt dominates public health allows industrialists well state actors today yesterday rely uncertainty means looking favourably reopening mining sites inhabited areas without taking account health issues cancer epidemic continues grow reaching estimated incidence new cases per year france compared uncertainty health effects industrial risks dangers proven still currently favours continuation conditions cause future cancers particularly among exposed carcinogens namely workers
increasing scale construction projects coupled complexity information management construction process becomes complex trivial moreover communication among project participants hindered large amount scattered structure information involved construction process present studies information management construction focus special needs construction sectors rather total information integration general aspects paper presents multidimensional information model combines workflow work breakdown structures wbs time factor manage information based process control unlike previous researches present work puts emphasis process control enhance communication process proposed information model uses wbs time factor manage information spatial time dimension control process information work package project execution workflow technology order test proposed information model web based project management system wpms developed using three layer architecture system structure realizes invisible logic information model business logic layer data access layer system applied construction project underground cavern group hydropower project southwest china application shown achieves managing information based process control provides structured information
aggressive behavior frequently observed men women diagnosed borderline personality disorder bpd assumed bpd also frequent among prisoners sentenced violent crimes fulfil criteria bpd aggressiveness bpd patients predominantly exclusively reactive closely linked emotional dysregulation central psychopathological feature bpd association bpd aggressive behavior mediated via emotional dysregulation tendency frequent fierce feelings anger sense sequential mediation interpersonal rejection situations typically serve triggers link tendency bpd patients experience social threat context low labile self confidence level underlying neurobiological mechanisms functional disorders prefrontal limbic cerebral network assumed control serotonin anti stress sex hormones based current knowledge aggression individuals bpd seems realistic assume specific psychotherapeutic perhaps even pharmacological treatment approaches become available future reduce reactive aggressive behavior patient group
robotics technology obtain information several sensory modalities touch vision hearing etc needed robots interact perceive environment indeed robots always physical contact operational environments many factors motivate robot detection physical contact ranging safe robot operation around humans robot behaviors depend user guidance tactile sensing different sensory modalities vision hearing requires physical contact objects paper focus domain tactile sensing robotics introduce basic aspects tactile sensors research analog signal processing techniques
myelofibrosis chronic progressive myeloproliferative neoplasm characterized anemia splenomegaly debilitating symptoms leukemic transformation ruxolitinib oral jak inhibitor highly effective ameliorating systemic symptoms reducing splenomegaly current clinical research focused evaluation agents based pre clinical rationale result disease course modification panobinostat pan histone deacetylase inhibitor demonstrated clinical activity single agent early phase trials myelofibrosis previously conducted phase trial panobinostat monotherapy patients myelofibrosis determined thrice weekly recommended phase dose completed investigator initiated simon stage phase trial myelofibrosis patients single institution cycles therapy overall response rate iwg mrt criteria median percent reduction spleen volume range eight evaluable patients average reduction jakvf allele burden range one patient obtained complete molecular response six patients remained therapy extension phase median months range treatment discontinuation frequent due patient physician perception therapy ineffectiveness optimal dosing panobinostat treatment remains somewhat ill defined appears effective better tolerated administered lower doses prolonged duration therapy elsevier ltd rights reserved
psychopathic personality disorder subject many research papers particular context forensic settings link risk future violence established topic well examined still considerable debate nature construct psychopathy measured contemporary models triarchic theory patrick fowles krueger put forward yet research psychopathy tends rely one assessment tool psychopathy checklist revised pcl hare argued capture elements psychopathy boldness triarchic psychopathy measure tripm patrick measure based triarchic theory places equal focus boldness measuring psychopathy however self report instrument approach many limitations paper aims review scientific support tripm discuss potential application clinical practice concludes tripm may yet contender pcl throne sole tool choice psychopathy measurement research application tripm expanding understanding psychopathy construct elsevier ltd rights reserved
avoidance allergens treatment asthma hitherto achieved significant benefit despite strong evidence allergy increases severity contributes exacerbations asthma house dust mite cat dog allergens common perennial allergic triggers avoidance strategies focused reducing exposures bedrooms cochrane reviews suggested neither significantly reduce allergen levels improve asthma lack efficacy may assumed consequence exposures occurring outside bedroom prolonged sleep associated increased susceptibility bronchospasm airway inflammation thus efficient reductions allergen exposure could achieved sleep might expected would result significant improvements control asthma temperature controlled laminar airflow tla system employed beds domestic environment results massive reductions particulate exposure recumbent subjects including highly respirable allergens fel cats trials tla demonstrated highly significant improvements asthma quality life reductions airway inflammation monitored exhaled nitric oxide levels furthermore patients worst disease severe exacerbation frequency significantly reduced based health service costs use tla falls well national institute health care excellence nice threshold incremental cost effectiveness ratio icer per quality adjusted life year qaly indeed frequent exacerbations cost saving prescribed allergic asthmatic patients
hundreds scientific studies competencies limitations eyewitnesses published sought input front line forensic interviewers current study research agenda established depth input forensic interviewers interviewers indicated techniques use often rated usefulness various interview techniques disclosed common challenges interviewing although many recommended techniques used cognitive interview rapport building techniques shown effective eliciting quality testimony scientific studies always used considered useful front line interviewers permission correct interviewer permission say know key areas identified guide future research techniques interviewing young children witnesses developmental delays
time dependent bridge pier scour flood waves analysed scour experiments conducted novel installation able produce complex hydrographs high precision experimental data used test scour formulas including new mathematical model results confirm reliability superior performance proposed dimensionless effective flow work based model steady unsteady hydraulic conditions analyses highlight impact different hydrographs scour demonstrating strong control hydrograph shape temporal evolution scour depth scour rate although final scour flood depends total effective flow work exerted hydrograph sediment bed hysteresis flow discharge scour rate reported explained flow acceleration shown play minor role scouring proposed model promising alternative computation local scour highly unsteady hydraulic conditions
cerebral microbleeds cmbs indicate hemorrhage prone disease may associate hemostatic abnormalities association cmbs coagulation function uncertain aimed examine possible association following coagulation function indicators evaluated consecutive ischemic stroke patients diagnosed atrial fibrillation rheumatic heart disease prothrombintime activated partial thromboplastin time aptt levels dimer fibrinogen indicators assessed within admission cmbs identified based published criteria two experienced stroke neurologists working independently appt levels dimer fibrinogen compared patients without cmbs using univariate multivariate analysis cmbs detected patients fibrinogen levels patients independently significantly higher patients without cmbs adjustment whereas two types patients differ significantly appt dimer levels presence cmbs ischemic stroke patients atrial fibrillation rheumatic heart disease associated elevated levels fibrinogen larger prospective studies needed verify association explore mechanisms involved
place women agency fertility transition late nineteenth early twentieth century contested one argue transition achieved mainly male methods contraception others including many arguing australian perspective contend women agency fertility decline significant article authors revisit issue women agency australia drawing range archival sources scholarship seek demonstrate women australia last quarter nineteenth century access contraception albeit limited failed abortion authors argue changing political educational climate saw women gaining vote south australia admission secondary higher education paid work provided setting women changing status increasing agency agency many women worked secure encouraged women challenge many traditional practices
paper response kathleen raviele recent article critical analysis use levonorgestrel given women postsexual assault suggestion use meloxicam may ethical alternative
tendons connect muscles bone often targets sports injuries currently unsatisfactory state tendon repair largely attributable limited understanding basic tendon biology number tendon lineage related transcription factors recently uncovered provide clues better understanding tendon development scleraxis mohawk identified critical transcription factors tendon development differentiation transcription factors sox egr also recently reported involved tendon development however molecular mechanisms application transcription factors remain largely unclear prohibits use tendon therapy systematically review analyze recent findings data concerning tendon transcription factors tendon regeneration based findings provide interaction temporal programming maps transcription factors basis future tendon therapy finally discuss future directions tendon regeneration differentiation trans differentiation approaches based transcription factors
cognitive decline older adults contributes reduced ability perform daily tasks continued disuse leads muscle weakness potentiates functional loss despite explicit links motor cognitive systems health care providers assess motor function addressing needs individuals cognitive loss early easy measurable biomarkers cognitive decline potential improve care individuals dementia mild cognitive impairment aim study conduct systematic search determine relationship among handgrip strength measure global muscle strength cognitive decline time fifteen prospective cohort longitudinal studies adults years old healthy risk cognitive decline study onset included review studies investigated changes cognition relative baseline grip strength investigated changes grip strength relative cognitive function revealed findings support use handgrip strength way monitor cognitive changes show reduced handgrip strength time may serve predictor cognitive loss advancing age elsevier rights reserved
new state space representation class combinatorial optimization problems related minimal hamiltonian cycles enables efficient implementation exhaustive search minimal cycle optimization problems relatively small number vertices heuristic search problems large number vertices paper surveys structures representing hamiltonian cycles use structures heuristic optimization techniques efficient mapping structures along respective operators newly proposed electrooptical vector matrix multiplication vmm architecture record keeping mechanisms used improve solution quality execution time heuristics using vmm finally utility low power vmm based implementation evaluated
aim study test whether association belief world bjw internet altruistic behavior iab mediated gratitude self esteem sample chinese undergraduates total participants aged completed paper pencil questionnaire assessed bjw self esteem gratitude internet altruistic behavior mplus used conduct structural equation modeling estimate direct indirect effects path analysis showed self esteem gratitude partially mediated relationship bjw iab final model also revealed significant path bjw thorough self esteem gratitude iab limitations implications research practical application present study discussed elsevier ltd rights reserved
background dural enhancement characteristic finding spontaneous intracranial hypotension hypertrophic pachymeningitis positional headache important feature distinguishes two diseases report patient granulomatosis polyangiitis formerly wegener granulomatosis initially manifested like spontaneous intracranial hypotension case presentation report case year old man presented severe positional headache patient typical symptoms symmetric dural enhancement recent history nontraumatic subdural hygroma led diagnosis spontaneous intracranial hypotension finally diagnosed granulomatosis polyangiitis associated secondary hypertrophic pachymeningitis cyclophosphamide therapy effective maintenance remission conclusions hypertrophic pachymeningitis associated granulomatosis polyangiitis present positional headache subdural hygroma mimicking spontaneous intracranial hypotension granulomatosis polyangiitis suspected patients spontaneous intracranial hypotension hypertrophic pachymeningitis show atypical features
convenient use generator range extender also starting engine torque needed engine early stage engine cranking modeled sum torques developed starter generator rotational inertia including flywheel sufficiently large order overcome compression torque ensure successful start engine order minimize torque required electric motor concept flywheel effect used brings possibility downsize converter reducing torque demand motor one limit current drawn source thereby giving reliability switching devices
paper stability issue lur systems governed control law stabilising forward euler approximate model investigated specifically considered control law obtained exploiting advantages new lur type lyapunov function disconnected level sets lyapunov function adapted discrete time lur systems structure forward euler approximate model main result consists linear matrix inequality conditions allowing guarantee continuous time lur system associated proposed digital control law globally asymptotically stable relevance approach illustrated using numerical example
online question answering systems popular helpful programming community systems users post questions answer questions collaboratively tag questions vote quality answers paper implements link structure based top experts learners finding algorithm using stanford network analysis project snap library experiments done real data taken stack overflow mainly focuses computer programming results show link analysis techniques suitable analyzing online question answering systems
novel graphene quantum dot gqd feo sio based nanoprobe reported targeted drug delivery sensing dual modal imaging therapy carboxyl terminated gqd gqd firstly conjugated feo sio functionalized cancer targeting molecule folic acid dox drug molecules loaded gqd surface feo sio gqd nanoprobe via stacking resulted feo sio gqd dox conjugates based fret mechanism gqd donor molecules dox acceptor molecules meanwhile successfully performed vitro mri fluorescence imaging living hela cells monitored intracellular drug release process using feo sio gqd dox nanoprobe cell viability study demonstrated low cytotoxicity feo sio gqd nanocarrier enhanced therapeutic efficacy feo sio gqd dox nanoprobe cancer cells luminomagnetic nanoprobe potential platform cancer accurate diagnosis therapy
blood brain barrier bbb plays important role clinical expression neuropsychiatric symptoms systemic illness health neurological disease evidence vitro preclinical vivo studies indicate systemic inflammation impairs blood brain barrier function order investigate hypothesis evaluated association systemic inflammatory markers leucocytes erythrocyte sedimentation rate reactive protein bbb function cerebrospinal fluid serum albumin ratio consecutive lumbar punctures absence cerebrospinal fluid csf abnormality systemic inflammation affect csf serum albumin ratio csf abnormality present systemic inflammation significantly predicted csf serum albumin ratio amongst systemic inflammatory markers reactive protein predominant driver effect temporal analysis association study suggested causality conclusion diseased bbb increased susceptibility systemic inflammation authors published elsevier inc open access article license
objective examine relationship serum hydroxyvitamin level disease activity male patients ankylosing spondylitis materials methods study enrolled male patients followed hospital patient demographics well serum levels vitamin reactive protein crp calcium phosphorus alkaline phosphatase parathormone erythrocyte sedimentation rate esr hour recorded patients divided two groups based serum vitamin levels one group consisted patients vitamin levels less group comprised patients levels greater bath ankylosing spondylitis disease activity index basdai scores evaluated order determine disease activity results basdai scores statistically significantly higher group serum vitamin levels less compared group levels statistically significant difference groups terms esr serum levels crp parathormone calcium phosphorus alkaline phosphatase conclusion present study inverse relationship found serum vitamin levels disease activity male patients concluded serum vitamin levels also taken account developing treatment plan
background asperger syndrome autism spectrum disorder characterized significant difficulties social interaction nonverbal communication restricted repetitive patterns behavior interests difficulties respect pragmatic speech reading emotional social cues differentiating fact fiction taking account influence context statement commonly described features however hitherto established questionnaires focus symptoms methods study present short questions questionnaire focuses self rated pragmatic speech abilities freiburg questionnaire linguistic pragmatics fqlp psychometric properties questionnaire explored sample patients asperger syndrome patients psychiatric disorders convenience sample people results reliability analysis showed high cronbach strong correlations could demonstrated fqlp autism quotient empathy quotient concerning divergent validity moderate correlation found fqlp self rated symptoms personality disorders significant correlation found fqlp vocabulary skills receiver operating characteristics curve showed excellent diagnostic accuracy fqlp conclusions control group consisted people without mental disorder patients different psychiatric disorders results indicate construct examined fqlp quite specific peculiarities fqlp reliable brief valid instrument first results regarding sensitivity specificity highly promising
looking global energy demands development highly efficient stable semiconductor photoelectrodes photoelectrochemical pec water splitting highly desirable herein fabricated catalytic nanoparticles decorated silicon nanowire sinws hematite feo core sell structures photo anodes studied pec water oxidation properties feo possess weak oxidation kinetics decoration nio coo nanoparticles sinw feo hydrothermal method acts catalysts improves water oxidation reactions found decoration coo nanoparticles enhances photocurrent times whereas nio nanoparticles improvement times compared undecorated electrodes along enhancement photocurrents also shows shift onset potentials effect catalytic nanoparticles enhancement photocurrent charge transfer resistance interface electrode electrolyte studied electrochemical impedance spectroscopy flat band potentials photo electrodes measured using mott schottky analysis
background inappropriate sexual behaviour sexual problems sexual victimization adolescents autism spectrum disorders asd regularly reported previous research little known factors associated problems factors associated healthy sexuality development adolescents asd investigating judgement sexual behaviour first step acquiring insight inappropriate sexual behaviour adolescents asd methods assessed cognitively able adolescents asd typically developing adolescents judged appropriateness different illustrations sexual situations investigated differences two groups results highest level agreement judgements adolescents asd judgements expert panel found severely inappropriate sexual behaviours lowest agreement found appropriate slightly inappropriate sexual behaviours significant differences found judgements adolescents asd adolescents regarding divergent judgements adolescents without asd mostly strict conservative expert panel judgement sexual situations finally small percentage adolescents without asd showed milder less conservative judgements sexual situations portraying behaviour considered severely inappropriate expert panel conclusions findings showed overall judgement illustrations sexual situations seem hampered adolescents asd research needed clarify whether also holds true judgements actions complex real life situations elsevier ltd rights reserved
clinical forensic medicine cfm single discipline encompasses number areas medico legal practice including injury interpretation management sexual physical assault cases adult child alleged victim offender mental health issues traffic medicine custodial medicine toxicology cases usually alive jurisdictions forensic practitioner also engages death investigation undertaking autopsies last years discipline fragmented areas hived medical specialist disciplines importantly nurses user forensic services wants best value money particularly financial pressure end governments sought savings privitisation services utilisation less qualified personnel undertake tasks places cfm crossroads ensure survival discipline needs reconsider direction performance convince stakeholders relevance importance lift profile within legal academic medical world need think outside square place greater emphasis clinical relinquish activities better undertaken less expensive qualified personnel establishment meaningful research academic centres essential loss failure grow cfm result loss skills base subsequent potential miscarriages justice elsevier ltd faculty forensic legal medicine rights reserved
linear buffer strips along watercourses commonly adopted reduce run accumulation bank top sediments leaking pesticides fresh waters strongly increase water pollution however monitoring conditions difficult task scattered wide rural areas work demonstrates benefits using standard data layer augmented reality watershed control outlines guideline novel approach health check linear designed mobile environmental monitoring system smart maintenance riverbanks embedding technology within geographical information system gis technological point view system architecture consists cloud based service data sharing using standard data layer mobile device provided gps based engine augmented data visualization proposed solution aims ease overall inspection process reducing time required run survey indeed ordinary operational survey conditions usually performed basing fieldwork classical digitized maps application proposes enrich inspections superimposing information device screen point view camera providing intuitive visualization buffer strip location way inspection officer quickly dynamically access relevant information overlaying geographic features comments contents real time solution tested fieldwork prove extent cutting edge technology contributes effective monitoring large territorial settings aim encourage officers land managers practitioners toward effective monitoring management practices elsevier ltd rights reserved
purpose purpose study provide epidemiological profile injuries sustained participants fitness activities victoria australia based hospital admissions emergency department presentations identify common types causes sites injuries method hospital treated fitness activity related injury cases identified international classification disease activity codes admissions text narratives injury events presentations inclusive cases categorized associated aerobics group exercise resistance weight training equipment motorized general gym equipment participation information taken exercise recreation sport survey results overall cases identified patients presentations subsequently hospitalized participants aerobics cases generally female aged years old injuries lower limbs due falls resistance training injuries increased significantly year period generally occurred male participants people aged years old injuries upper limbs caused hit struck crushed weights fellow exercisers equipment cases equally distributed gender occurred commonly people aged years old injuries lower limbs due falls across categories dislocations sprains strains common injury types conclusions fitness activity related injury prevention strategies targeted different subgroups according type fitness activity undertaken
aims epidemiological studies strongly suggest link stress depression cardiovascular diseases cvds mechanistic correlation however poorly understood single nucleotide polymorphism bdnf gene bdnfvalmet associated depression anxiety proposed genetic risk factor cvd using knock mouse carrying bdnfvalmet human polymorphism phenocopies psychiatric related symptoms found humans investigated impact snp thrombosis methods results bdnfmet met mice displayed depressive like phenotype concomitantly hypercoagulable state platelet hyper reactivity proteomic analysis aorta secretome bdnfmet met wild type mice showed differential expression proteins involved coagulation inflammatory cascades bdnf met allele predisposed carotid artery thrombosis fecl induced death collagen epinephrine injection interestingly transfection bdnfmet construct induced prothrombotic proinflammatory phenotype cells sirt activation using resveratrol cay prevented thrombus formation restored physiological levels coagulation platelet markers bdnfmet met mice cells transfected met allele conversely inhibition sirt sirtinol specific sirna induced prothrombotic proinflammatory phenotype mice cells finally found bdnf met homozygosity associated increased risk acute myocardial infarction ami humans conclusion activation platelets alteration coagulation pathways changes vessel wall protein expression bdnfmet met mice recapitulate well features occurring anxiety depression condition furthermore data suggest bdnfvalmet polymorphism contribute individual propensity arterial thrombosis related ami
background drug survival defined time period treatment certain drug cessation role previous exposure traditional systemic treatments biologic survival still unknown objective investigate drug survival rates biologic treatments patients psoriasis identify predictor factors methods survival analysis performed patients severe psoriasis received adalimumab infliximab etanercept ustekinumab treatment psoriasis drawn clalit health services database multivariate analysis performed adjusting demographic variables metabolic syndrome components psoriatic arthritis biologic naivety coadministration methotrexate acitretin cyclosporine previous standard systemic treatment exposure results among patients treated biologic treatments ustekinumab significantly higher survival rate tumor necrosis factor inhibitors biologic naivety concomitant methotrexate intake positive predictors drug survival whereas female sex duration previous systemic treatments negative predictors limitations data regarding disease severity duration could drawn clalit health services database conclusion ustekinumab better retention rates comparison investigated biologics patients severe psoriasis used third line therapy
nonnegative matrix factorization widely used clustering tasks group data points features simultaneously recent years several proposed clustering algorithms shown superiorities traditional one side clustering especially text clustering gene expression due completeness clustering problems existing methods relaxed orthogonality constraint nonnegativity often deteriorates performance robustness result paper penalized nonnegative matrix tri factorization proposed clustering problems three penalty terms introduced guarantee near orthogonality clustering indicator matrices iterative updating algorithm proposed convergence proved furthermore high order nonnegative matrix tri factorization technique provided symmetric clustering tasks corresponding algorithm proved convergence also developed finally extensive experiments six real world datasets demonstrate proposed algorithms outperform compared state art clustering methods elsevier ltd rights reserved
mechanical gearboxes typically employed doubly fed induction generator based wind turbines main drawback solution gearbox reliability maintenance using magnetic gearbox conjunction doubly fed induction generator emerging alternative promoted research community maintains reduced size doubly fed machine overcomes mechanical gearbox problems reported field experience paper proposes novel magnetic gearbox configuration conventional planetary magnetic gearbox equipped phase coils fitted around ferromagnetic pole pieces extract output electrical power turbine mechanical power thus divided mechanical power drive electrical generator extra electrical power diverted storage system perform power leveling function proposed configuration also used freely modify power speed characteristic seen electrical generator highly needed feature grid frequency support
psoriasis chronic autoimmune disease cured however controlled various forms treatment including topical systemic agents phototherapy topical treatment first line treatment favored physicians form therapy patient compliance introducing nanoemulsion transporting cyclosporine anti inflammatory drug itchy site skin disease would enhance effectiveness topical treatment psoriasis addition nutmeg virgin coconut oil mixture unique properties could improve cyclosporine loading solubility high shear homogenizer used formulating cyclosporine loaded nanoemulsion optimal mixture experimental design used optimization nanoemulsion compositions order understand relationships behind effect independent variables oil surfactant xanthan gum water content physicochemical response particle size polydispersity index rheological response viscosity value investigation variables suggests two optimized formulations specific oil surfactant xanthan gum water content possessed intended responses good stability separation months storage different temperatures optimized nanoemulsions studied types stability analysis physical stability coalescencerate analysis ostwald ripening freeze thaw cycles vitro release proved efficacy nanosize emulsions carrying cyclosporine across rat skin synthetic membrane best fit korsmeyer peppas kinetic model vivo skin analysis towards healthy volunteers showed significant improvement stratum corneum skin hydration
think related issues changing investment plan management lower yellow river flood control project accordance yellow river conservancy commission changes construction management system new situation financial budget management combined construction characteristics lower yellow river recent flood control project related suggestion annual investment plan scale lower yellow river flood control project investment plan classification management annual investment implementation plan investment control management design variation management put forward
background chronic hepatitis fibrosis progression rates extremely variable influenced factors associated host virus environment among associated metabolic factors hepatic steatosis characterized accumulation triglycerides hepatocytes host genetic determinants hepatic steatosis observed single nucleotide polymorphisms snps microsomal triglyceride transfer protein mttp gene mttp snp appears play important role regulation gene expression influences plasma concentration circulating low density lipoprotein ldl present study investigated influence snp development hepatic steatosis patients chronic hepatitis evaluated association hepatic steatosis certain characteristics patients hepatitis virus hcv methods two hundred thirty nine patients chronic hepatitis genotyped mttp snp polymerase chain reaction restriction fragment length polymorphism pcr rflp assay association hepatic steatosis selected characteristics patient virus evaluated using bivariate multivariate analyses results prevalent mttp genotype followed multivariate analysis total cohort revealed associations presence hepatic steatosis inflammatory activity moderate high intensity advanced age elevated gamma glutamyl transpeptidase ggt levels low ldl levels hepatic steatosis also associated genotype mttp snp patients infected hcv genotype conclusions chronic hepatitis patients infected hcv genotype genotype mttp snp significant increase hepatic steatosis observed may indicate snp significant influence accumulation triglycerides hepatocytes furthermore associations observed hepatic steatosis inflammatory activity moderate high intensity advanced age elevated ggt low ldl levels
study analyzed records patients outpatients treated acute sports injuries trauma department university groningen netherlands years examined whether trend sports injuries time period study comprised four types sports soccer volleyball gymnastics martial arts absolutely highest rates injuries across seven years found soccer followed gymnastics volleyball martial arts injuries sustained participating soccer volleyball gymnastics involved major part lower extremities followed injuries upper extremities whereas reverse pattern observed patients participated martial arts four types sport ankle foot frequently site injury lower extremities sprains strains major types injury injuries seen ages years ratio male female patients within age groups differ significantly across seven years concluded except martial arts increased participation sports last decade accompanied change patterns sports injuries patients age sex number nature injury consistency results used guide development prevention programs aimed reduction injuries specific sports
background mental illness disease affects millions people every year causes stress mentally ill patients also family members provide care family caregivers therefore need form coping strategies dealing mentally ill family members aims qualitative study aims identifying analysing coping strategies adopted family caregivers dealing mentally ill family members method total family caregivers state kedah malaysia participated face face semi structured interview results study findings identified array coping strategies used family caregivers including religious coping emotional coping acceptance becoming engaged leisure activities use traditional healing help cope mentally ill members suggestions conclusions study suggests family caregivers engage social support groups learn obtain positive coping strategies used caregivers similar experiences caring mentally ill study also suggests get appropriate training mental health professionals order enhance caregivers coping skills
evidentiary point view project ross cheit seeks accomplish book witch hunt narrative politics psychology sexual abuse children remarkably complex examine methodology underlies cheit scholarship assess strength claims cheit work strong methodological core asserts existence witch hunt narrative whn public perception hundreds legal cases involving innocent adults wrongly criminally pursued child sexual abuse identifies three foundational cases whn mcmartin michaels fuster along dozens others distills published lists using broadly collected archival data cheit investigates veracity whn concludes insufficient evidence substantiate witch hunt claim methodologically cheit research veers problematic territory seeks extend whn claims beyond central core extend academy particularly research several prominent academics including psychologists stephen ceci maggie bruck examine claims argue cheit paid sufficient attention methods methodology upon bases claims conclude noting complexity evaluating evidence produced utilized across disciplinary boundaries including journalism law academy nonetheless cheit scholarship raises plethora important questions possibilities future research
purpose cerebral palsy intellectual disability developmental disabilities result considerable functional limitations recent nationally representative prevalence estimates united states methods used two nationally representative surveys national survey children health nsch national health interview survey nhis determine prevalence based parent report among children aged years results prevalence confidence interval per nsch nhis prevalence nsch nhis respectively conditions nsch nhis prevalence estimates similar nearly sociodemographic subgroups examined conclusions despite using different modes data collection two surveys produced similar plausible estimates offer opportunities better understand needs situations children conditions published elsevier inc
objectives emotion recognition impairments demonstrated schizophrenia less consistent lesser magnitude bipolar disorder may related extent different face processing strategies engaged emotion recognition disorders recently showed patients impairments use featural configural face processing strategies whereas patients impaired use latter examine influence impairments facial emotion recognition cohorts methods twenty eight individuals individuals healthy controls completed facial emotion labeling task two conditions designed separate use featural configural face processing strategies part based whole face emotion recognition results patients performed worse controls conditions worse patients whole face condition patients performed worse controls whole face condition conclusions configural processing deficits appear influence recognition facial emotions whereas configural featural processing abnormalities impair emotion recognition may explain discrepancies profiles emotion recognition disorders
distributed generators distribution networks brought much influence fault current traditional fault section locating algorithm distribution networks may work paper new switching function built used distribution network single power supply multi power supplies regional processing method used paper divides distribution network several independent regions fault locating algorithm used independent regions regions without connection eliminated fault current detected complexity computation fault section location reduced ant colony algorithm good optimization algorithm swarm intelligence positive feedback fault tolerance distributed computing features good application effect locating faulty section distribution network attained order overcome disadvantages large amounts calculation long searching time local optimal ant colony algorithm improved adaptive dynamic modifying pheromone ant system elitist strategy mmas also used paper improved algorithm used distribution network multi distributed generators results example analysis show effective good fault tolerance algorithm
background peanut allergic reactions heterogeneous ranging mild symptoms anaphylaxis objective identify peanut allergic sensitized phenotypes personalize patient management methods combined factor cluster analysis used study phenotypes patients diagnosed peanut sensitization enrolled mirabel survey method first applied patients oral food challenge ofc applied patients without ofc confirm findings independent population results three independent clusters emerged ofc subgroup cluster severe peanut allergy little allergic multi morbidity subjects highest proportion patients positive ofc medium level peanut protein inducing positive ofc lower percentage allergic multi morbidity asthma plus atopic dermatitis cases multiple food allergies mfa cluster severe peanut allergy frequent allergic multi morbidity subjects high proportion patients positive ofc lowest level peanut protein inducing positive ofc allergic subjects allergic multi morbidity mfa cluster mild peanut allergic sensitized phenotype subjects lowest mean age lowest proportion patients positive ofc high level peanut protein inducing positive ofc low percentage allergic multi morbidity mfa two severe peanutallergic phenotypes frequent girls clusters found subgroup patients without ofc conclusion clinical relevance besides classic markers associated lower threshold doses ofc spt rara allergic multi morbidity female gender also taken account better adapt progressive dosage provocation tests
important conditions associated hypothyroidism cardiac dysfunction apelin endogenous ligand involved energy storage metabolism improves cardiac contractility study done evaluate effects apelin thyroxin combination cardiac function mrna expression two contractile proteins alpha beta myosin heavy chain alpha mhc beta mhc propyl thiouracil ptu induced hypothyroid rats forty male wistar rats randomly assigned five groups ctrl control hypothyroid groups hat hypothyroid group received ptu drinking water six weeks next groups along ptu received apelin day day gavage combination drugs hat last weeks weeks tsh measured using elisa kit isolated hearts animals perfused langendorff apparatus left ventricular developed pressure cardiac contractility heart rate rate pressure product perfusion pressure assessed using powerlab adinstruments addition alpha mhc beta mhc mrna expression evaluated pcr method heart tissue apelin alone accompanied significantly increased cardiac contractility performance compared hypothyroid group apelin also significantly increased alpha mhc mrna expression presence significantly decreased beta mhc mrna expression seems apelin alone may improve cardiac function hypothyroid rats via genomic pathways elsevier rights reserved
paper proposes led driving circuit digital controller power factor correct pfc function low light flicker key topology proposed circuit conventional flyback combined pre stage result less light flicker one stage pfc circuits digital controller implemented using low cost microcontroller dspicf meet pfc low light flicker experimental results validate functionality proposed circuit
high rise building construction highly complex involves many different disciplines projects accomplished efficiently appropriate quality means overall optimized construction process however understanding term quality among involved participants always equivalent providing required tolerances elevator shaft walls constantly throughout concrete works often challenging task execution situ concrete works paper based scientific research project efficiency optimization quality control engineering geodesy processes civil engineering effizienzoptimierung qualitatssicherung ingenieurgeodatischer prozesse bauwesen equip aimed developing method instant quality assurance construction based geodetic surveying techniques time optimizing efficiency process respect time paper shows hierarchical modular modeling construction geodetic processes using high level petri nets delivers base real time quality evaluation planning construction site example modeling approach simulated construction concrete stairs elevators core characteristic high rise structure concrete works considered carried using climbing form work three different scenarios shown paper first scenario simulated deterministic durations validates developed petri net second scenario uses stochastic process durations show robustness construction process finally disturbances delays integrated automated rescheduling based prioritized alternative paths used elsevier rights reserved
facial landmark detection important issue many computer vision applications faces challenging human faces wild conditions often present large variations shape due different poses occlusions expressions deep neural networks applied learn map face images face shapes best knowledge recurrent neural network rnn used issue yet paper propose method utilizes rnn deep neural network dnn learn face shape first build global network using long short term memory lstm architecture rnn get initial landmark estimation faces use feed forward neural networks local search component based searching method explored using lstm rnn initial estimation reliable makes following component based search feasible accurate experiments show global network using lstm rnn gets better results previous networks videos single image method outperforms state art algorithms especially terms fine estimation landmarks published elsevier
paper presents implementation research project focused use robotics effective tool teaching technical disciplines dyslexic children dyslexia common learning disability affects percent students goal project develop educational programs boost school performance dyslexic children using robotics science technology engineering mathematics education stem studies shown robots help students develop problem solving abilities learn computer programming mathematics science however studies discuss use robots special education present basic concept using robotics mean teach subjects describe courses developed research project department biomedical science university medicine pharmacy grigore popa iasi project implemented answer needs dyslexic children
background blood injection injury phobia capable producing inaccurate hypoxic challenge testing results due anxiety induced hyperventilation case report old woman history hypersensitivity pneumonitis restrictive spirometry exercise desaturation requiring supplementary oxygen mobilizing reduced dlco phobia referred hypoxic challenge testing hct assess flight oxygen requirements hct performed breathing gas mixture simulating available oxygen ambient air onboard aircraft pressurized equivalent altitude fell nadir value hct although rapidly increased first two attempts blood gas sampling resultant blood gas sample showed acceptable outside criteria recommending flight oxygen reduced pco entering nadir value severinghaus equation gives estimated arterial kpa mmhg felt representative resting values hct flight oxygen recommended discussion hyperventilation expected response hypoxia transient rises coinciding threat injury likely attributable emotional stress induced hyperventilation characteristic specific phobia expected anticipation exteroceptive threat even normal subjects summary excessive hyperventilation detected hct coincide transient increases hct repeated using guide level hypoxemia spot maintained using supplementary oxygen accordance alternative methods described guidelines
like true memories false memories capable priming answers insight based problems recent research attempted extend paradigm advanced problem solving tasks including involving verbal analogical reasoning however experiments constrained inasmuch problem solutions could generated via spreading activation mechanisms much like false memories rather using complex reasoning processes three experiments examined false memory priming complex analogical reasoning tasks absence simple semantic associations experiment demonstrated robustness false memory priming analogical reasoning backward associative strength among problem terms eliminated experiments extended findings demonstrating priming newly created homonym analogies solved inhibiting semantic associations within analogy overall findings present experiments provide evidence efficacy false memory priming extends complex analogical reasoning problems
micrornas mirnas reported play critical roles tumor progression including hepatocellular carcinoma hcc thus underlying mechanisms need investigation previous study reported loss mir expression indicated poor prognosis hcc patients study evaluated whether loss mir could promote tumor metastasis epithelial mesenchymal transition emt hcc targeting interferon regulatory factor irf mediated mtor stat akt signaling underexpression mir identified cases human hcc compared matched tumor adjacent tissues qrt pcr moreover found reduced expression observed hcc cell lines restoration mir inhibited cell migration invasion hcclm cells loss facilitated cell mobility hepg cells furthermore mir overexpression reduced lung metastases hcc cells nude mice notably mir overexpression prohibited knockdown enhanced emt process hcc cell lines vitro bioinformatics software predicted irf direct target mir observed negative regulation mir irf protein expression direct binding verified dual luciferase assays hcc cells addition overexpression irf mrna inversely correlated level mir hcc specimens restoration irf resulted promoted emt cell mobility mir overexpressing hcclm cells found mtor stat akt pathway downstream targets including slug snail twist may involved irf mediated emt process conclusion mir acts inhibitor emt process hcc cells targeting irf study highlights potential effects mir prognosis treatment hcc
though people report idiosyncratic desires particular traits ideal romantic partner studies examined whether ideals predict important long term relationship outcomes present year longitudinal study newlywed couples used survival analysis investigate whether match participants ideal preferences traits perceive partner predict likelihood divorce results depended entirely whether match conceptualized match level high ideal preference trait presence trait partner pattern within person correlation ideals partner traits across traits match pattern ideals traits negatively predicted divorce effect size larger established divorce risk factors however match level unrelated divorce suggesting perspectives emphasizing ideals level traits may encounter predictive validity problems
invasive fungal infections important cause morbidity mortality hospitalized patients immunocompromised population article reviews current epidemiology nosocomial fungal infections adult patients emphasis invasive candidiasis aspergillosis recently published recommendations guidelines control prevention nosocomial fungal infections summarized article
work describe relative performance largest luminescent solar concentrator lsc constructed date comparisons made performance north south east west facing panels sunny day shown east west panels display much varied performance day structural elements barrier interfere solar illumination cause shading perform similarly front back illumination conditions results extended day measurement period mirror results single sunny day results work demonstrates importance frame design minimize self shading lsc panels authors published elsevier ltd
magnetic properties silicon steel laminations important features power transformer electrical machine design manufacture conventional testing methods epstein frame single sheet tester may consider one direction one sheet may deviate real application particularly core loss calculation magnetic properties testing method proposed paper using designed special surface sensing coils dynamic magnetic hysteresis properties laminated non grain oriented silicon steel sample accurately measured relationship alternating rotational spherical rotational excitations studied analyzed order control waveform better harmonics signals analyzed alternating core losses rolling transverse laminated directions rotational core losses xoy plane sample calculated analyzed moreover core losses three directions well predicted means total core loss separation theory
background dogmatism prejudice strongly related hypothesized bias disconfirmatory evidence bade might explain portion relationship unique explained constructs including political orientation bade measured bade task comprises two facets evidence integration impairment positive response bias evidence integration impairment expected partially explain prejudice dogmatism relationship prior research alone associated group differences inflexible beliefs method mturk participants completed measures dogmatism racial prejudice bade evidence integration impairment positive response bias political orientation hypothesized mediation effect examined using bootstrapping procedure results dogmatism predicted racial prejudice relationship weakened presence measures confidence interval size indirect effect dogmatism racial prejudice via evidence integration impairment include zero confirming hypothesized mediation effect conclusions evidence integration impairment accounts unique portion relationship dogmatism racial prejudice suggesting belief revision failures ambiguous social situations may support prejudice dogmatic individuals elsevier ltd rights reserved
paper investigates active disturbance rejection control involving fractional order tracking differentiator fractional order pid controller compensation fractional order extended state observer nonlinear fractional order systems firstly fractional order optimal time control scheme studied propose fractional order tracking differentiator hamilton function fractional order optimal conditions secondly linear fractional order extend state observer offered acquire estimated value sum nonlinear functions disturbances existing investigated nonlinear fractional order plant disturbance existing feedback output effect disturbance discussed choose reasonable parameter fractional order extended state observer thirdly observed value nonlinear fractional order plant converted linear fractional order plant adding compensation controller aid real root boundary complex root boundary imaginary boot boundary approximate stabilizing boundary respect integral differential coefficients determined given proportional coefficient integral order differential order choosing suitable parameters fractional order active disturbance rejection control scheme deal unknown nonlinear functions disturbances finally illustrative examples given verify effectiveness fractional order active disturbance rejection control scheme copyright john wiley sons ltd
work proposes clusterization algorithm called morphological sets based morphological reconstruction heuristics faster cpu parallel means worst case scenarios produces enhanced visualizations dataset well distinct clusterizations also faster similar clusterization methods sensitive density shapes mitosis triclust addition deterministic intrinsic sense maximal clusters created given input sample input parameters differing means clusterization algorithms words given constant structuring element dataset produces less clusters without using random pseudo random functions finally proposed algorithm also provides straightforward means removing noise images datasets general
background computer aided design draft along computer aided engineering software used widely different fields create modify analyze optimize designs methods used computer aided design draft software create dimensional model aerobiology chamber built accordance specifications guideline environmental protection agency studies survival inactivation microbial pathogens indoor air model used optimize chamber airflow design distribution aerosolized bacteria inside results findings led identification appropriate fan location inside chamber uniform distribution microbes introduced air suitability air sample collection center chamber alone representative bacterial content determination influence room furnishings airflow patterns inside chamber conclusions incorporation modeling study findings could improve design chamber predictive value experimental data using could make data generation faster economical eliminating need collecting air samples multiple sites chamber association professionals infection control epidemiology inc published elsevier inc rights reserved
native chickens gallus domesticus bangladesh scavenging nature data regarding morphology lymphoid organs prenatal stages lacking staining method performed study development bursa fabricius thymus spleen cecal tonsil embryonic day budding thymus seen fiber network thymus formed create basement cells thymus cells began organize form cortex medulla cortex medulla thymus could differentiated plicae bursa fabricius started develop plicae became shorter wider form bursal follicles follicles clearly organized cortex medulla thin capsule seen embryonic spleen white pulps observed purple colored white pulp pinkish red pulp easily visible thickness capsule increased pulps distinguishable lymphoid organs showed major development later incubation period indicating immune system period prepared face scavenging environment hatching pvj rights reserved
development new products manufacturing systems usually performed form projects frequently conduction project takes time planned due inconsistency incompleteness redundancy data delays project activities influencing start production sop paper proposes semantic web framework cooperation interoperability within product design manufacturing engineering projects data knowledge within manufacturing domain modelled within ontologies applying rule based mapping framework facilitates generation new knowledge rule based inference enriches ontology enables high level model completeness early phase product design manufacturing system development basic prerequisite realisation proper simulation study analysis simulation results integrated ontologies knowledge additionally extends ontology
neurotropic substance ethanol damage nerve cells increase production free radicals interference neurotrophic factor signaling pathways activation endogenous apoptotic signals molecular mechanisms previous studies revealed number natural drugs extracted plants offer protection nerve cells damage among arctigenin atg lignine extracted arctium lappa found exert neuroprotective effect scopolamine induced memory deficits mice alzheimer disease glutamate induced neurotoxicity primary neurons result may offer beneficial effects ethanol induced neurotoxicity however effects atg ethanol induced nerve damage remain elucidated address issue present study used rat pheochromocytoma cells investigate neuroprotective effects atg ethanol induced cell damage performing mtt reduction assay cell cycle analysis hoechst propidium iodide fluorescence staining flow cytometry examine apoptosis results showed atg effectively promoted proliferation damaged cells increased distribution ratio cells phases addition apoptosis necrosis cells significantly decreased following treatment atg therefore concluded atg protective effect ethanol induced injury cells
one widely used techniques improve quality existing software systems refactoring process improving design existing code changing internal structure without altering external behavior important suggest refactorings improve quality structure system many criteria also important consider reducing number code changes preserving semantics software design behavior maintaining consistency previously applied refactorings article propose multi objective search based approach automating recommendation refactorings process aims finding optimal sequence refactorings improves quality minimizing number design defects minimizes code changes required fix defects iii preserves design semantics maximizes consistency previously code changes evaluated efficiency approach using benchmark six open source systems different types refactorings move method move field pull method pull field push method push field inline class move class extract class extract method extract interface six commonly occurring design defect types blob spaghetti code functional decomposition data class shotgun surgery feature envy empirical study conducted experts addition performed industrial validation technique software engineers large project provided industrial partner found proposed refactorings succeed preserving design coherence code acceptable level code change score reusing knowledge recorded refactorings applied past similar contexts
service requirements digital audio broadcasting dab satellites presented plans implementing systems various countries surveyed technical economic constraints including satellite transmitter power frequencies operation transmission bandwidth service interference user receiver design discussed particularly dab systems employing mobile receiving terminals transmission outage blockage multipath fading must addressed transmission performance improvement techniques spatial diversity modulation coding interleaving described illustration specific satellite dab system design presented show technical economic feasibility new services
sustained prenatal hypoxia decreases growth metabolic rate embryo causes blunted hypoxic ventilatory response hvr newborn likely interpretation sustained hypoxic stimulation may interfere normal prenatal development chemoreceptors however wanted consider possibility prolonged hypoxic hypometabolism may contributing factor chicken embryos incubated degrees cold group known lower embryonic oxygen consumption dot similar throughout incubation degrees controls cold incubation delayed hatching similar days day old hatchlings normal pulmonary ventilation dot measured barometric technique oxygen consumption dot simultaneously measured open flow methodology acute hypoxia similar similar hyperventilation increase dot dot hyperpnea hypometabolism almost identical two groups hatchlings conclude sustained decrease metabolic rate embryonic period carry obvious consequences newborn resting dot hvr elsevier rights reserved
order effectively prevent direct indirect losses lightning disasters bring coastal ports guarantee security production paper proposes establish lightning forecast system ports based cloud technology includes three functions collecting underlying lightning data analyzing predicting based cloud big data technology pushing warning information platform fully effectively collect lightning raw data upload data storage resource pool use distributed computing lightning location algorithm multi level threshold judgments lightning warning signal generates pushed mobile terminals immediately people start lightning protection plans advance keep safety work reduce equipment damages caused lightning
goal study estimate prevalence current lifetime mental disorders consecutive sample detainees prison inmates held italian prison compare prevalence observed sample randomized community within age interval years sex proportion prisoners similar socio economic status psychiatric disorders identified mini international neuropsychiatric interview mini current psychiatric disorders present prisoners comparison group lifetime psychiatric disorders present prisoners comparison group current anxiety disorders current stress related disorders related prisoners serving first ever prison sentence variable fraction prisoners ongoing psychopathology diagnosed receive proper treatment provision effective treatment prisoners psychiatric disorders might potentially substantial public health benefits elsevier ireland ltd rights reserved
previous studies demonstrated associations serum levels perfluoroalkyl substances pfass asthma asthma related biomarkers however studies reported possible relationship pfass exposure lung function among children objective present study test association pfass exposure lung function children high exposure area using cross sectional case control study included asthmatic children non asthmatic controls recruited genetic biomarkers study childhood asthma structured questionnaires administered face face lung function measured spirometry linear regression models used examine influence pfass lung function results showed asthmatics study significantly higher serum pfas concentrations healthy controls logistic regression models showed positive association pfas asthma adjusted odds ratios ors ranging confidence interval linear regression modeling showed serum pfass levels significantly negatively associated three pulmonary function measurements forced vital capacity fvc forced expiratory volume fev forced expiratory flow fef among children asthma adjusted coefficients lung function pfass exposure ranged fvc perfluorooctane sulfonate pfos fef perfluorooctanoic acid pfoa pfas however significantly associated pulmonary function among children without asthma conclusion study suggests serum pfass associated decreased lung function among children asthma
objectives assess association obesity control inflammatory activity increased adverse effects psoriatic arthritis psa disease modifying anti inflammatory drugs dmard methods systematic literature review performed using medline embase databases following guidelines meta analysis observational studies epidemiology moose consensus statement studies selected included patients psa obesity studied predictive factor outcome adverse effects including efficacy failure quality assessed using hoc risk bias tool qualitative analysis carried type study study population quality specific results results found articles discarding basis title abstract ten articles studied detail finally excluded three majority concluded statistically significant results patients psa treated tnf alpha inhibitors tnf alpha obesity associated poorer chances achieving maintaining minimal disease activity higher treatment discontinuation rates lower skin response regarding conventional synthetic dmard trend toward moderate increase transaminases methotrexate mtx observed obese patients psa conclusions obesity negative predictor clinical response patients psa treated tnr alpha except mtx hepatotoxicity adverse effects either tnr alpha drugs found relation obesity psa elsevier espalia sociedad espaliola reumatologla colegio mexicano reumatologla rights reserved
paper presents series considerations regarding role conceptual invariants concerning prevention artefacts obsolescence emphasis software engineering concept artefact meaning defined bocu bocu emphasizing invariants role goal allow understanding respective approximation invariants role considering continuous qualitative progress human artefacts generally speaking also connection software systems engineering
study investigated comorbidity hoarding symptoms sample african american adults obsessive compulsive disorder lifetime disorders participants least one comorbid condition prevalent comorbidities mood disorders anxiety disorders substance abuse disorders low comorbidity eating disorders binge eating disorder none met criteria anorexia bulimia nervosa terms gender differences females likely posttraumatic stress disorder males likely comorbid alcohol use disorder half participants hoarding compulsions indicated yale brown obsessive compulsive scale individuals hoarding compulsions likely comorbid anxiety related disorders without experienced greater indecisiveness pathological slowness doubting also less education earning power without behaviors african americans obsessive compulsive disorder tend high rates comorbid disorders patterns resemble findings non hispanic white populations
objectives study determine stillborn calves born following dystocia present specific injuries pathological changes compared stillborns delivered without difficulty whether stillborns differ conformation dystocic calves survive post mortem examinations carried stillborns either unassisted farm staff assisted normally presented birth evidence greater trauma bruising observed calves parameters body length birth weight thyroid body weight similar second part study birth weight body length height girth length body mass bmi ponderal indices assessed calves regardless severity dystocia stillborns greater body lengths lower bmis pis calves born alive suggesting prenatal factors contribute post natal survival calves heavier calves farm staff assisted malpresented calves lower pis calves study found criteria grossly visible carcass haemorrhage bruising brain congestion reliable terms identifying calves experienced dystocia half stillborns breathed indicating alive possibly experienced pain distress time delivery body conformation related stillbirth independently dystocia finding likely reflecting inadequate prenatal development elsevier ltd rights reserved
purpose subgroup individuals anorexia nervosa displays social difficulties however clear individuals comorbid autism spectrum disorders account difficulties methods compared social function using autism diagnostic observation schedule young females first episode comorbid autism spectrum disorder individuals recovered adolescent onset healthy comparison individuals age range years measured adaptive behavior vineland parent questionnaire aspects social cognition psychological tests reading mind eyes test profile nonverbal sensitivity short version awareness social inference test animated triangles cantab affective task results participants first episode recovered displayed difficulties social function associated body mass index state factors disorder first episode mood problems anxiety associated difficulties parents rated participants first episode lower recovered control participants socialization domain vineland finally participants recovered demonstrated deficits specific domains social cognition perceiving nonverbal bodily gesture vocal prosody conclusions young females first episode recovered displayed impairments social function may represent stable traits disorder participants recovered demonstrated deficits social cognition society adolescent health medicine rights reserved
introduction frontline chemotherapy successful chronic lymphocytic leukemia cll results untoward toxicity prognostic factors cytogenetic anomalies compensatory cellular signaling lead therapy resistance disease relapse therefore past years development targeted therapies rise pik major player cell receptor bcr signaling axis critical survival maintenance cells duvelisib pik dual isoform specific inhibitor induces apoptosis reduces cytokine chemokine levels vitro holds promise cll areas covered herein review pik isoforms inhibitors general duvelisib particular examine literature preclinical investigations pharmacokinetics clinical studies duvelisib either single agent combination patients cll lymphoid malignancies expert opinion duvelisib targets pik isoform necessary cell proliferation survival isoform critical cytokine signaling pro inflammatory responses microenvironment phase clinical trials duvelisib single agent showed promise cll lymphoid malignancies phase iii trials duvelisib alone combination agents ongoing
self locomotion central animal behaviour survival generally analysed focusing preferred speeds gaits particular biological physical constraints present paper focus instead maximum speed study order magnitude scaling body size bacteria largest terrestrial aquatic organisms using data species various taxonomic groups find maximum relative speed order magnitude ten body lengths per second fold mass range running swimming animals result implies locomotor time scale order one tenth second virtually independent body size anatomy locomotion style whose ubiquity requires explanation building basic properties motile organisms first principle estimates relate generic time scale basic biological properties using particular recent generalisation muscle specific tension molecular motors finally step relating time scale still basic quantities environmental conditions earth addition fundamental physical chemical constants
beach nourishment accepted people coast protection damage reduction china information status benefits prospects documented fragmented incomplete study creates database includes beach nourishment episodes occurred along chinese coast total beach nourishment episodes occurred locations china past two decades shoreline replenished locations order reduce avoid additional dry beach decrease place semi submerged breakwater geotextile underlayment trap sediment prevent filled material sinking sandy coast nourishment popular type china rise coastal tourism real estate muddy beach nourishment developing furthermore conception coastal sediment cell understood accepted sediment management china larger volume sand placed entire littoral environment maintain favorable sediment status elsevier ltd rights reserved
main objective paper compare indicators based energy consumption financial savings rank strategies save potable water buildings method based potable water savings embodied energy energy consumption operation investment feasibility analysis applied school city florianopolis southern brazil strategies considered save potable water rainwater greywater water efficient appliances combinations embodied energy estimated using indices embodied energy per mass material labour indicators used rank strategies potential potable water savings index potable water savings embodied energy total energy consumption net present value internal rate return discounted payback index potable water savings initial costs strategies combinations feasible use water efficient appliances best amongst indicators used rank strategies five led ranking indicators applied rank potable water saving strategies types buildings climates elsevier rights reserved
androgen deprivation therapy adt standard treatment metastatic prostate cancer increasingly used stages disease well besides well known side effects caused lack testosterone impotency osteoporosis fatigue loss muscle mass increase cardiovascular morbidity mortality recently discussed association adt cardiovascular side effects sufficiently explained low testosterone levels review gives overview recent literature interprets results offers clinical consequences
background hepatitis infection major public health concern low middle income countries estimated million individuals living chronic infection world health organization recently released new guidance hepatitis virus hcv treatment programs include improving access new direct acting antiviral agents vietnam highly populated middle income country seroprevalence hcv infection approximately multiple genotypes circulate general population review currently known regarding epidemiology hcv vietnam outline options reducing significant burden morbidity mortality setting methods performed systematic review currently available literature evaluate achieved date efforts control hcv infection vietnam results search retrieved publications specific vietnam indicating significant gap baseline epidemiological public health data key knowledge gaps identified included understanding prevalence specific high risk groups characterization circulating hcv genotypes population likely response treatment extent hcv treatment available accessed utilized conclusions conclude urgent need perform date assessments hcv disease burden vietnam especially high risk groups incidence high cross infection multiple genotypes likely frequent coordinating renewed surveillance measures forthcoming hcv treatment studies initiate traction required achieve goal eliminating hcv public health threat least region
background prolactinomas commonest functional tumors pituitary gland still controversies regarding medical therapy specific clinical situations patients may managed different specialists middle east north africa mena region data exist patterns clinical management objectivesto ascertain diagnostic therapeutic approaches prolactinomas among relevant professionals mena region methods online survey large sample physicians conducted questionnaire covered various aspects diagnosis treatment prolactinomas respondents included endocrinologists worked public facilities graduated years would seen suspected confirmed prolactinomas months period respectively results regarding diagnosis respondents considered prolactin levels compatible macroprolactinomas whereas others accepted compatible also microprolactinomas macroprolactinaemia drug induced hyperprolactinemia respectively respondents favored screening macroprolactin asymptomatic individuals hyperprolactinemia regarding treatment respondents would treat microprolactinomas even absence symptoms whereas respondents would treat microprolactinomas symptoms exist respondents chose cabergoline drug choice treat macroprolactinomas microprolactinomas respectively similar proportions preference either cabergoline bromocriptine best treatment macroprolactinoma microprolactinomas respondents favored treatment withdrawal years prolactin normalization patients macroprolactinomas microprolactinomas respectively whereas respondents withdraw treatment menopause either case respondents considered medical therapy primary treatment microprolactinomas case pregnancy considered bromocriptine drug choice women wish become pregnant respondents advocated discontinuation treatment dopamine agonists patients microprolactinomas macroprolactinomas respectively finally would allow breast feeding without restriction would restrict patients microprolactinomas would recommend women prolactinomas conclusions first study clinical management prolactinomas mena region practices line latest endocrine pituitary societies guidelines warrant discussions contemporary guidelines regional forums
extracts han kuo siraitia grosvenorii high sweetness low calories widely used natural sweetener reduce risk obesity diabetes current study han kuo extracts extracted using subcritical water different operation condition study revealed optimal extracting parameters extraction time min extraction temperature degrees addition ethanol antioxidant activity contents total flavonoids total phenolic compounds han kuo extracts also investigated mathematical model established describe relationship antioxidant capacity content bioactive components han kuo extract found antioxidant capacity extracts mainly attributed yields total mogrosides
paper presents new topology implementing bandpass shadow filter using current feedback operational amplifier cfoa proposed circuit uses cfoas avoids use external summing circuit implement shadow bandpass filter controlled center frequency experimental results obtained using cfoa included
case study presented paper aimed discovering opportunities ambient intelligence new interaction methods future remote crane operating environment theoretical objective carry experience driven research project industrial work context practical objective create evaluate future oriented science fiction prototype work carried close operation industrial partner domain expert field crane industry aim focus clearly defined user experience goals industrial partner committed consequent immediate objective focus two explicit experiences relating feeling motivated sense community placed core design investigations experiences deliberated science fiction prototype entitled remote operator day future control center science fiction prototype introduced users twofold means plain simple short story interactive experience path main contribution paper demonstrate emerging technology research new domain may employ science fiction prototyping method primary means experience design investigations
background statistical analysis data visualization two crucial aspects molecular biology biology analyses compare one dependent variable standard control one multiple independent variables comprehensive yet highly streamlined solution valuable computer programming language popular platform researchers develop tools tailored specifically research needs present package rbioplot takes raw input data automated statistical analysis plotting highly compatible various molecular biology biochemistry lab techniques limited western blotting pcr enzyme activity assays method package built based workflows operating simple raw data layout minimum user input data manipulation required package distributed github easily installed one single line command detailed installation guide available http kenstoreylab com page users also download demo datasets website results discussion integrating selected functions existing statistical data visualization packages extensive customization rbioplot features statistical analysis data visualization functionalities key properties rbioplot include fully automated comprehensive statistical analysis including normality test equal variance test student test anova post hoc tests fully automated histogram heatmap joint point curve plotting modules detailed output files statistical analysis data manipulation high quality graphs axis range finding user customizable tick settings high user customizability
ability design effective solutions using parallel processing required competency every computing student however teaching parallel concepts sometimes challenging costly specially early stages computer science degree reasons present set modules teach parallel computing paradigms using examples problems computationally intensive easy understand easily implemented using python parallelization libraries mpi python disco
human target characteristic parameter extraction important approach behavior monitoring extraction characteristic applied various backgrounds sanatorium hospital therefore technology widely studied towards extracting physiological characteristic parameters motion characteristic features human target novel human parameter extraction algorithm proposed paper high detection accuracy high accuracy detection achieved combining time frequency analysis image processing algorithm besides utilization short wavelength evident micro motion features inherent terahertz radar also contributes improvement detection accuracy simulations test effectiveness proposed algorithm illustrate performance high extraction precision insensitivity noise comparison simulations also performed band radar via thorough simulations clearly find advantage proposed algorithm human target characteristic parameter extraction elsevier rights reserved
children syndrome may experience difficulties recognizing facial emotions particularly fear clear skills best facilitated using photo matching task emotion recognition tested children syndrome children nonspecific intellectual disability cognitively matched typically developing children groups four conditions veridical exaggerated emotions emotion labelling generic task instructions groups exaggerating emotions facilitated recognition accuracy speed emotion labelling facilitating recognition accuracy overall accuracy speed differ children syndrome although recognition fear poorer typically developing children unrelated emotion label use implications interventions considered
background advances cloning sequencing technology yielding massive number viral genomes classification annotation genomes constitute important assets discovery genomic variability taxonomic characteristics disease mechanisms existing classification methods often designed specific well studied family viruses thus viral comparative genomic studies could benefit generic fast accurate tools classifying typing newly sequenced strains diverse virus families results introduce virus classification platform castor based machine learning methods castor inspired well known technique molecular biology restriction fragment length polymorphism rflp simulates silico restriction digestion genomic material different enzymes fragments uses two metrics construct feature vectors machine learning algorithms classification step benchmark castor classification distinct datasets human papillomaviruses hpv hepatitis viruses hbv human immunodeficiency viruses type hiv results reveal true positive rates hpv alpha species hbv genotyping hiv subtyping respectively furthermore castor shows competitive performance compared well known hiv specific classifiers rega comet whole genomes pol fragments conclusion performance castor genericity robustness could permit perform novel accurate large scale virus studies castor web platform provides open access collaborative reproducible machine learning classifiers castor accessed http castor bioinfo uqam
vitro difficult infect resting cells human immunodeficiency virus type hiv infections readily occur vivo endothelial cells ecs interact resting cells vivo found previously stimulation leads productive latent hiv infection resting cells study characterize interactions resting cells found resting cells require direct contact productive latent infection occur indicating involvement soluble factors among cytokines tested multiplex enzyme linked immunosorbent assay elisa found expressions ccl much higher stimulated resting cells resting cells cultured alone found soluble factor responsible inducing productive infection resting cells although direct contact added effect however none cytokines tested ccl induced additional latent infection resting cells suggesting unidentified cytokines involved intracellular molecules murr jun terminal kinase jnk glucose transporter glut previously shown blocking hiv infection resting cells found concentrations proteins significantly different resting cells stimulation therefore likely involved stimulation resting cells new mechanism yet identified
vigabatrin highly effective antiseizure medication use limited due concerns retinal toxicity one proposed mechanism toxicity vigabatrin mediated reduction taurine herein assess plasma taurine levels retrospective cohort children epilepsy including subset receiving vigabatrin children underwent plasma amino acid analysis part clinical evaluation stanford children health included analysis significant differences plasma taurine levels children taking vigabatrin children taking anti seizure medications children taking anti seizure medication analysis variance anova however age dependent decreases plasma taurine levels multiple linear regression revealed significant association vigabatrin use plasma taurine level controlling age results suggest children taking vigabatrin maintain normal plasma taurine levels although leave unanswered whether taurine supplementation necessary sufficient prevent vigabatrin associated visual field loss also indicate age taken consideration evaluating taurine levels young children
titanium based alloy applications implantable material chemically graved different methods order improve adhesion thin hydroxyapatite film aim study increase biocompatibility metallic material deposition ceramic material surface metallic material known titanium grade tialv investigated scanning electron microscopy sem detector images energy dispersive ray analyser edax chemical attack deposition hydroxyapatite deposited using electrophoretic equipment time using experimental conditions comparison made deposition material calcined mechanical properties investigated experimental results present homogeneous layer formed good adhesion dimensionally reduced particles metallic material used dental implant presents better corrosion resistance simulated body fluid electrolyte eis electrochemical impedance spectroscopy tests emphasize formation two layers compact one tio titanium oxide porous one top surface
new fatigue reliability assessment function takes account vehicle temperature loadings developed study vehicle temperature loadings important parameters cause fatigue failure welds steel box girder temperature affects traffic loading effect changing elastic modulus asphalt pavement effect temperature difference considered based measured data finite element analysis linear regression equations equivalent stress temperature different vehicle types developed using thermal stress analysis rain flow counting method temperature difference fatigue stress spectrum determined limit equation fatigue reliability assessment takes account vehicle temperature loadings developed finally effects temperature traffic growth rate fatigue reliability two welding types nan yangtze river suspension bridge assessed elsevier ltd rights reserved
pythiosis life threatening infectious disease caused pathogenic oomycete pythium insidiosum study first evaluate insidiosum glucan content biological activities enzymatic quantification glucans insidiosum mycelia showed beta glucan content cell wall polysaccharide extract consisted similar carbohydrates exclusively glucose similar residual amino acids peptides results monosaccharide composition methylation nmr spectroscopy analyses indicated presence highly branched beta glucan beta glucopyranosil side branching unit average every repeat units vitro beta glucan extract could significantly promote spleen lymphocyte proliferation human equine mouse cell cultures balb mice subcutaneously pre immunized three doses beta glucan mouse showed significant increase tnf alpha production compared non immunized mice results suggested beta glucan extract induces significant specific cellular immune response provided theoretical basis experiments elsevier ltd rights reserved
aim study follow sample physicians began core medical training cmt paper examines long term validity cmt selection methods predicting performance membership royal college physicians mrcp examinations performed longitudinal study examining extent cmt selection methods predict performance mrcp examinations total applicants completed cmt selection methods included study looking mrcp part part written paces scores cmt selection methods show evidence predictive validity outcome variables hierarchical regressions show methods add significant value cmt selection process cmt selection methods predict performance important outcomes good evidence validity methods may additional role alongside cmt selection methods
based existing fracture theories temperature dependent fracture surface energy model temperature dependent fracture strength model zrb mosi composites established excellent agreement obtained model predictions experimental data model used qualitative even quantitative analysis effect sio size strength hot pressed composites high temperatures predict temperature dependent critical flaw size composites thus help discover control mechanisms material strength different temperatures effects microstructures flaw evolution strength zrb mosi high temperatures studied detail using model study shows critical flaw causing failure hot pressed composites high temperatures related largest sio grains fracture strength materials controlled combined effects temperature grains flaws increases temperature initial flaw size sensitivities fracture strength grain size flaw size decrease preparation composites reducing initial flaw size firstly considered improving starting powder purity sintering method could reduce amount sizes dispersion dispersed phases present microstructure mosi grain size initial flaw size would result greater strength materials high temperatures elsevier rights reserved
background health system responsiveness measures hsr non health aspect care relating environment way healthcare provided clients study measured hsr performance correlates hiv aids treatment care services wolaita zone ethiopia methods cross sectional survey across seven responsiveness domains attention autonomy amenities care choice communication confidentiality respect conducted people using pre art art care likert scale categories allocated percentages analysis classified unacceptable fail acceptable good good performance results participants health centers hospital respectively art pre art care respectively range response classifications reported domain fail performance higher choice attention autonomy domains communication amenities attention confidentiality domains higher scores good performance category hand respect domain higher score good performance category attention amenities choice domains low scores respect confidentiality communication showed low proportion fail performance responsiveness percent score rps fail good categories respectively rest good performance category multivariate analysis unit increase perceived quality care satisfaction services financial fairness scores respectively resulted increase rps contrary visiting traditional medicine practitioner formal hiv care associated decrease rps conclusion health facilities performed low autonomy choice attention amenities domains overall rps masked weaknesses strengths showed overall good performance domain specific responsiveness scores better ways measuring responsiveness improving quality care client satisfaction financial fairness important interventions improve responsiveness performance
recently interest photosynthetic energy conversion substantially increased chloroplasts photosynthetic organelle inside higher plants algae ultimate source carbon based fuels however less studied photobioelectrochemical cell electrochemical communication electrode surface challenging due complex membrane system although redox polymers widely used mediating bioelectrocatalysis never explored wiring chloroplasts electrodes herein naphthoquinone functionalized linear poly ethylenimine lpei redox polymer used electron transfer mediator well immobilization matrix chloroplasts immobilized toray carbon paper electrodes tps photoexcited water oxidation evaluated showing intact chloroplasts undergo direct electron transfer det mediated electron transfer met photocurrent generation det chloroplasts results oxidative current lpei modified electrodes oxidative photocurrent increased improved presence additional diffusive mediator dichlorobenzoquinone dcbq oxidative current produced presence light confirms ability oxidize water chloroplast modified electrode surface
study deals evaluation compliance map variability flexible structure using active material namely shape memory alloy sma compliance stiffness maps important indicator performances robotic structures mechanisms instance assess positioning error production task paper carefully examines impact combination compliant structure closed loop flexible structure sma spring various static compliance maps simulated analyzed respect state sma several aspects discussed concept pseudo workspace deriving deformation structure anisotropy non linearity compliance change well relevance large displacement framework strength materials sense correct calculation compliance maps results enable validate capability combination compliant structure sma component achieve variable compliance maps could used polyvalent robotic tasks
objectives group based cognitive behavioral therapy children aggressive behavior resulted significant reductions behavior problems small medium effect sizes report efficacy individualized treatment program children aggressive behavior method within subject design two phases waiting treatment chosen sixty boys aged years peer related aggressive behavior included course outcome measures growth rates week waiting phase compared subsequent treatment phase weekly child sessions together average parent contacts multilevel modeling primary outcome peer related aggressive behavior rated parents outcome measures included parent ratings patient self reports aggressive prosocial behavior results treatment growth rates parent rated outcome measures significant comparison waiting phase indicated stronger decrease aggressive behavior stronger increase prosocial behavior self rated outcome measures growth rates treatment significant comparison waiting phase indicated stronger decrease disturbance social interaction conclusions treatment program effective intervention children peer related aggressive behavior
industrial practice condition monitoring typically applied critical machinery particular piece machinery may condition monitoring system allows health condition said piece equipment assessed independently connected assets however industrial machines typically complex sets components continuously interact one another cases dynamics resulting inception development fault propagate individual components example fault one component may lead increased vibration level faulty component well connected healthy components cases condition monitoring system focusing specific element connected set components may either incorrectly indicate fault conversely fault might missed masked due interaction piece equipment neighboring machines cases holistic condition monitoring approach account interactions utilize provide complete definitive diagnostic picture health machinery highly desirable paper two stage bayesian inference approach allowing data separate condition monitoring systems combined presented data distributed condition monitoring systems combined two stages first data fusion occurring local component level second fusion combining data global level data obtained experimental rig consisting electric motor two gearboxes load operating range different fault conditions used illustrate efficacy method pinpointing root cause problem obtained results suggest approach adept refining diagnostic information obtained different machine components monitored therefore improving reliability health assessment individual element well entire piece machinery
welding important joining technique offers advantage customizable plate thicknesses hand welding causes residual stresses deformations influencing load carrying capacity consideration design requires simple fast models though welding simulation contributed accurately access values nowadays application large components remains still less practicable range nevertheless many studies emphasized need make corrections recently available simplified models especially influence residual stresses seems somewhat overestimated many cases comparing conventional structural steel high strength steel times computer aided design improved procedure implement weld inducted imperfections appears overdue presented two parts first part illustrates potential influence post welding imperfections exemplified weak axis buckling comparison general method accordance eurocode residual stresses initial crookedness varied systematically order produce scatter band capacities approach characterize borders imperfections untertaken excessive scattering reduction factors load bearing capacity demonstrates importance variables results finally evaluated advanced simulation models detailed part two contribution
due unpredictable varied often physical nature law enforcement duties police officers high risk work related physical injury aim critical narrative review identify synthesize key findings studies investigated musculoskeletal injuries sustained law enforcement officers occupational tasks systematic search four databases using key search terms conducted identify potentially relevant studies assessed key inclusion exclusion criteria determine studies included review included studies critically appraised level evidence determined relevant data extracted tabulated synthesized identified studies ranged percentage quality scores mean score high interrater agreement scores reflected cohen kappa coefficient common body site injury upper extremity common injury types soft tissue sprains strains common cause injury non compliant offender often involving assault however limited peer reviewed research area published research narrow focus low fair methodological quality
background despite global efforts hiv related stigma continues negatively impact health well people living hiv aids even healthcare settings people hiv aids experience discrimination anecdotal evidence suggests healthcare professionals lao people democratic republic lower middle income country situated southeast asia stigmatize hiv aid patients purpose study assess hiv stigmatizing attitudes within laotian healthcare service providers examine factors associated hiv aids related stigma among doctors nurses methods structured questionnaire included hiv related stigma scale consisting items self completed healthcare workers hospitals vientiane five hospitals excluded less staff staff always present questionnaire pre tested healthcare workers descriptive statistical analysis performed comparisons groups undertaken using chi square test test bivariate multiple linear regression analyses carried examine associations stigmatizing attitudes independent variables results participating healthcare workers doctors nurses nearly doctors nurses included study high levels stigmatizing attitudes towards people living hiv aids across different health professionals included study lower levels hiv aids knowledge associated higher levels stigmatizing attitudes towards people living hiv aids stigmatizing attitudes including discrimination work fear aids prejudice lower healthcare workers experience treating hiv aids patients conclusions study first report hiv aids related stigmatization among healthcare workers lao pdr stigmatizing attitudes contribute missed opportunities prevention education treatment undermining efforts manage prevent hiv reversing stigmatizing attitudes practices requires interventions address affective cognitive behavioral aspects stigma alongside health professionals need enabled enact universal precautions prevent occupational transmission hiv
purpose rehabilitation nurses essential responsibility detailed functional independence measure fim documentation accurate scoring goal performance improvement project improve individual fim accuracy establish maintain fim accuracy standard design case study methods performance improvement project implemented bed carf accredited midwestern acute care hospital inpatient rehabilitation unit findings improved individual overall fim scoring accuracy increased length stay case mix index conclusions concurrent fim scoring documentation review holds staff accountable allows timely revisions following discrepancy identification leadership supports concurrent fim audits utilization available technology transparent reporting results individual accountability lead sustained improvement fim scoring accuracy clinical relevance accurate fim documentation scoring drive appropriate length stay case mix group assignment assessment competence enhances nursing engagement confidence process accountability
role affect become increasingly important ambient intelligence applications developers require means using multiple tools support emotion detection interpretation used jointly provide meaningful system responses user varied situations introduce vikara extensible software platform provides developers uniform interfaces services applications access results existing newly implemented tools emotion sensing interpretation vikara also provides components make possible platform managers visually monitor affective states sensed various available tools experimented platform via development applications emotion detection using well known facial action coding system kinect sensor self reporting interface android based mobile devices report initial results using platform discuss ambient intelligence scenarios see potential applications including user experience usability evaluation marketing distance education inter personal communication
paper frequencies low order vertical modals three tower self anchored suspension bridge tssb studied first three tower self anchored suspension bridge taken prototype paper finite element model bridge established dynamic characteristics analyzed based rayleigh method frequency formulas asymmetric vertical vibration avv symmetric vertical vibration svv deduced considering contribution towers stiffness accuracy deduced formulas validated results numerical analysis modal test stiffness characteristic difference tssb multi tower earth anchored suspension bridge mesb researched based frequency formulas significant difference gravity stiffness component frequency formulas last influence law tower stiffness vertical frequencies studied based validated formulas results indicated middle tower stiffness side tower stiffness play important role frequency avv svv respectively frequencies enlarging tower stiffness increasing tower stiffness low deduced frequency formulas formulas neglecting influence tower stiffness reference paper based deduced frequency formulas expressions critical tower stiffness simplified formulas proposed
background clinical features attention deficit hyperactivity disorder frequently observed cases bipolar disorders associated greater severity bipolar disorders although designed screening tool attention deficit hyperactivity disorder wender utah rating scale could given factorial structure useful investigating early history impulsive inattentive mood related symptoms among patients bipolar disorders methods rated wender utah rating scale adult bipolar disorder cases healthy controls tested factorial structure associations bipolar disorder phenomenology results confirmed three factor structure wender utah rating scale impulsivity temper inattentiveness mood self esteem cases controls differed significantly wender utah rating scale total score sub scale scores values bipolar disorder cases versus controls classified wurs positive odds ratio bipolar disorders higher wender utah rating scale score associated earlier age onset severity suicidal behaviors polysubstance misuse multivariate analyses controlling age gender confirmed associations age onset alcohol substance misuse conclusion adults bipolar disorders reported higher levels childhood symptoms wender utah rating scale presented severe expression bipolar disorders terms age onset comorbidity wender utah rating scale could employed screen attention deficit hyperactivity disorder also risk behaviors adult bipolar disorder cases possibly prodromal signs early onset high risk subjects
context awareness key feature ambient intelligence future intelligent systems order achieve context aware behavior applications must able detect context information recognize situations correctly decide context aware action representation context information manner context detected central issues based previous work used graphs represent context graph matching detect situations paper present platform completely handles context matching real time background deferring matching component acts incrementally relying previous matching results platform implemented tested aal inspired scenario
muscle strains quadriceps group common occur mostly rectus femoris strains occur often muscles suddenly activated stretch either eccentric concentric contraction report cases vastus lateralis strain occurred association clinical histories patellofemoral pain syndrome symptoms described included anterior knee pain associated prolonged sitting knee flexed anterior knee pain associated running stair climbing jumping symptoms preceded acute strain least year cases emphasize clinician need understand knee biomechanics need consider entire kinetic chain managing pain injury extremity
security important aspect information system terms confidentiality integrity availability relational databases remotely accessed shared network growing economical value data real world cryptography watermarking two kinds security mechanisms cryptography provide posteriori protection data watermarking appears interesting security mechanism provide copyright protection ownership verification data watermarking relational databases one fastest growing areas research paper proposes new method increasing capacity privacy watermarking based circular histogram modulation taking host system colour image increasing capacity beneficial secure transmission huge databases like hospital records network
tested whether chronic supplementation resveratrol phytoestrogen could improve cerebrovascular function cognition mood post menopausal women eighty post menopausal women aged years randomised take trans resveratrol placebo weeks effects cognitive performance cerebral blood flow velocity pulsatility index measure arterial stiffness middle cerebral artery using transcranial doppler ultrasound cerebrovascular responsiveness cvr cognitive testing hypercapnia assessed mood questionnaires also administered compared placebo resveratrol elicited increases cvr hypercapnic cognitive stimuli significant improvements observed performance cognitive tasks domain verbal memory overall cognitive performance correlated increase cvr mood tended improve multiple measures although significantly results indicate regular consumption modest dose resveratrol enhance cerebrovascular function cognition post menopausal women potentially reducing heightened risk accelerated cognitive decline offering promising therapeutic treatment menopause related cognitive decline
spreading depolarizations long cumulative duration implicated lesion development progression patients stroke traumatic brain injury spreading depolarizations evolve less likely aged brain remains determined age susceptibility spreading depolarizations starts decline especially ischemia spreading depolarizations triggered epidural electric stimulation prior ischemia induction cortex weeks old anesthetized rats cerebral ischemia achieved occlusion common carotid arteries spreading depolarization occurrence confirmed acquisition potential electrocorticogram cerebral blood flow variations recorded laser doppler flowmetry dendritic spine density cortex determined golgi cox stained sections spreading depolarization initiation required increasingly greater electric charge older age potential outcome consolidation cortical connections indicated altered dendritic spine distribution threshold spreading depolarization elicitation increased ischemia age groups may caused tissue acidosis increased conductance among factors conclusion brain appears susceptible spreading depolarizations adolescent age therefore spreading depolarizations may occur young patients ischemic traumatic brain injury highest probability
circle hough transform cht one popular circle detection algorithm image processing machine vision application favored tolerance noise nevertheless involves huge computation excessive memory requirements drawbacks various modifications suggested increase performances paper present new modification cht method developed automatic biometric iris recognition system novelty method resides use incremental property order reduce resources requirement parallel property decreasing computation time incremental property obtained using approximation used trigonometric functions parallel property achieved calculating time several point coordinates circle software implementation validation done matlab real images errors analysis performances proposed method basic cht method presented paper elsevier gmbh rights reserved
aims patient selection weight management treatment option often guided variety factors currently comprehensive tool facilitate informed decision making patients clinicians article aims synthesise evidence treatment effectiveness health benefits risks patient experiences treatment options presently available weight management clinic ottawa hospital toh first step towards developing decision aid methods narrative systematic reviews published english included focused one following weight management treatments adults aged years roux gastric bypass rygb sleeve gastrectomy medically supervised meal replacement behavioural lifestyle intervention results overall bariatric surgeries received greatest research attention associated greater weight loss health benefit also greater risks complications financial cost dietary programmes demonstrated weight loss health benefits lesser extent surgery associated lower shorter term risks complications behavioural lifestyle interventions studied less yet shown significant albeit small weight loss outcomes alone combination dietary surgical options also appear lowest risk interventions patient experiences weight management options mixed well understood conclusion research needed however review identified general trends related weight loss outcomes benefits risks barriers weight management options implications shared treatment decision making
background excessive gambling considered part addiction spectrum stress like emotional states key feature pathological gambling substance addiction substance addiction stress symptomatology attributed part anti reward allostatic neuroadaptations potential involvement anti reward processes course yet investigated methods end individuals mentally healthy subjects assessed trauma exposure post traumatic stress symptomatology ptss using life events checklist civilian mississippi scale respectively results comparison healthy subjects individuals significantly greater ptss scores including greater physiological arousal sub scores number traumatic events recency significantly different groups group greater gambling severity associated ptss neither traumatic events exposure recency conclusions data replicate prior reports role traumatic stress course extend findings suggesting link may derived anti reward type neuroadaptation rather traumatic stress exposure per
purpose describe methods preferred contraception evaluate preferences adherence modern contraceptive methods determine factors associated contraceptive choices among tertiary students south east nigeria methods questionnaire based cross sectional study sexual habits knowledge contraceptive methods patterns contraceptive choices among pooled sample unmarried students three largest tertiary educational institutions enugu city nigeria done statistical analysis involved descriptive inferential statistics level confidence results total unmarried students studied males females mean age years males females made contraceptive choices based information peers preferences contraceptive methods among female students traditional methods contraception modern methods nonpharmacological agents label drugs adherence modern contraceptives among female students among male students preference male condom adherence condom use multivariate analysis showed receiving information health personnel media workshops odds ratio confidence interval health science related course study odds ratio confidence interval previous sexual exposure prior university admission odds ratio confidence interval increased likelihood adherence modern contraceptive methods conclusion overwhelming reliance peers contraceptive information context poor knowledge modern methods contraception among young people could contributed low preferences adherence modern contraceptive methods among students tertiary educational institutions programs reduce risky sexual behavior among students may need focus increasing content adequacy contraceptive information held people regular health worker led campus workshops
screening number chiral stationary phases csps different modifiers supercritical fluid chromatography find chromatographic method separation enantiomers time consuming computational methods data analysis utilized establish hierarchical screening strategy using dataset drug like chiral compounds diverse structures tested csps two different modifiers dataset analyzed using combinatorial algorithm principal component analysis pca correlation matrix primary goal find set eight columns resolving large number compounds also complementary enantioselective properties addition hereby defined hierarchical experimental strategy quantitative structure enantioselective models qsers evaluated diverse chemical space relatively limited size training set reduced accuracy qsers however including separation factors csps increased accuracies qsers substantially hence combined models support experimental strategy prioritizing csps second screening phase compound separated primary set columns
advances high throughput proteomics led rapid increase number size complexity associated data sets managing extracting reliable information large series data sets require use dedicated software organized consistent pipeline reduce validate exploit ultimately export data compilation multiple mass spectrometry based identification quantification results obtained context large scale project represents real challenge developers bioinformatics solutions response challenge developed dedicated software suite called heidi manage combine identifications semiquantitative data related multiple lcms analyses paper describes user friendly interface heidi used compile analyses retrieve lists nonredundant protein groups moreover heidi allows direct comparison series analyses basis protein groups ensuring consistent protein inference also computing spectral counts heidi ensures validated results compliant miape guidelines information related samples results stored appropriate databases thanks database structure validated results generated within heidi easily exported pride xml format subsequent publication heidi downloaded http biodev extra cea docs heidi
purpose aim study compare lower urinary tract symptoms luts women without type diabetes mellitus subjects setting sample drawn community dwelling women province istanbul cared diabetes outpatient clinic istanbul medical school january june two hundred forty nine women compared women without cared obstetrics gynecology department university hospital mean ages groups years respectively methods participants completed questionnaire queried sociodemographic clinical characteristics bristol female lower urinary tract symptoms short form bfluts used evaluate luts questionnaire required minutes complete participants completed questionnaire private room respective outpatient clinics results statistically significant differences found groups women without compared based age cigarette smoking contrast bmi scores significantly higher women cumulative bfluts scores filling incontinence symptoms subscale sores significantly higher women differences observed voiding symptoms sexual function health related quality life subscale scores prevalence storage symptoms nocturia voiding frequency urge incontinence stress incontinence frequency incontinent episodes higher among women addition women likely report need change clothing urinary leakage effect incontinence daily tasks overall interference daily activities living conclusions women type likely experience luts compared women without women type routinely assessed luts
background men sex men msm group impacted human immunodeficiency virus hiv epidemic subgroup united states among new hiv diagnoses decreasing achieve national hiv aids acquired immunodeficiency syndrome strategy goals reducing new diagnoses high coverage multiple hiv prevention interventions needed urban rural areas mobile phone apps important channel prevention services could provided scale low marginal cost objective aim study evaluate usability acceptability theory based android mobile phone app hiv prevention methods app included self assessment tools prevention recommendations commodity condoms hiv self tests ordering reminders msm basic hiv prevention services hiv testing condom use screening preexposure prophylaxis prep nonoccupational postexposure prophylaxis npep prevention treatment provider locators study recruited hiv negative android using msm atlanta seattle asked use app months complete post use survey measured use app features ordering commodities self report establishing hiv testing plan hiv tested community starting prep using npep usability assessed using system usability scale sus results total msm enrolled atlanta seattle median age nearly half nonwhite gay identified tested hiv past plan test hiv regularly men used app average minutes first months month period half ordered condoms hiv test kits app eight prep eligible msm started prep month period reported app influenced decision start prep mean sus average conclusions theory based mobile phone app acceptable msm rated average usability men used commodity ordering features app month evaluation period nearly prep eligible men started prep attributing decision start prep part app broader randomized controlled study impact app uptake prevention behaviors msm warranted
nowadays electrical power networks around world faced new challenges problems designed built fifty years ago thus meet requirements rapid development modern society increase electrical power consumption strict specifications power quality stability meanwhile increasing number countries embracing renewable energy solar power wind power tidal power etc distribution generators electrical power network result new mathematical model power network different traditional transmission network thus need something new tackle issues smart grid solution addition smart grid terminal use monitor essential part due administration control visualization functionalities paper plan design smart grid electricity monitor assist observation consumer use whilst also detecting maintaining electrical network smart electricity monitor receive data substations via communication network processing information labview program analyse data output graphically professional users
tobacco smoking smoke exposure pregnancy associated range adverse health outcomes including preterm birth also children born preterm higher risk complications including bronchopulmonary dysplasia asthma mothers smoked pregnancy smoking cessation early pregnancy help reduce adverse impact offspring health counselling interventions effective promoting smoking cessation reducing incidence preterm birth peer support incentive based approaches likely additional benefit whereas effectiveness pharmacological interventions including nicotine replacement therapy definitely established smoke free legislation help reduce smoke exposure well maternal smoking rates population level associated reduction preterm birth helping future mothers stop smoking protect children second hand smoke exposure must key priority health care workers policy makers alike elsevier ltd rights reserved
paper presents enhancement previous conventional carbon nanotube field effect transistor cntfet compact model proposed raychowdhury improvement consists three new extensions previous work first adding adequate electronic noise sources cntfet modelling electronic noise source drain access regions thermal noise electronic noise device channel flicker shot noise second adopting simple fast analytical calculating approach models schottky barrier source drain metal access semiconducting carbon nanotube cnt interface including adequate noise sources finally proposing generic compact model suitable circuit simulation purpose order validate proposed cntfet compact model electrical simulation results compared literature reported experimental results good agreement observed large range device biases assessment operational amplifier amp circuit designed simulated using cntfet compact model significant degradation amp performances observed large proprieties associated cnt geometry diameter prevent circuit performances degradation optimization work carried provide circuit design community suitable cnt diameters made
pre ejection period pep reactivity reward posited specific index behavioral approach incentive motivation suggesting might uniquely associated affective motivational deficits anhedonia study evaluated pep reactivity reward task predictor depressive symptoms among adolescents examining global depressive symptoms well specific anhedonic nonanhedonic symptoms clusters participants included adolescents ages years female study found marginal support association pep reactivity reward concurrent anhedonia symptoms association nonanhedonic global scale findings discussed terms potential associations peripheral psychophysiological measures dopaminergic functioning also utility measure future research anhedonia
non celiac gluten sensibility relevant disorder enough scientific studies specific bio markers identify strictly pathology separately others gastrointestinal disorders later diagnosis could lead number pathologies necessarily intestinal area lead chronic autoimmune inflammatory neoplastic disease symptoms usually reported immediately healthcare professionals given many affected patients consider relevant base pathology likewise relate possible sensitivity gluten believe problems derived age situations indigestion heavy meals medication side effects furthermore tests performed patients symptoms rule celiac disease food intolerance often negative discarding gluten involved disorders makes disease affecting slowly patient health could lead serious complications
paper presents design measurement results novel frequency mixing transimpedance amplifier tia key building block towards monolithically integrated optical sensor front end frequency domain near infrared nir spectroscopy nirs tia employs feedback network incorporating gate controlled transistor resistance modulation enabling simultaneous conversion amplification high frequency modulated photodiode current proposed tia capable operating either traditional wideband mode frequency mixing mode depending applied gate control voltage wideband post amplifier implemented chip characterize modes comparative study wideband mode achieves omega transimpedance gain mhz bandwidth photodiode capacitance measured total integrated input referred current noise rms tia modulated mhz signal amplitude mixing mode achieves omega conversion gain measured compression point iip input referred current noise integrated khz rms times lower wideband mode noise tia together post amplifier draws power supply output buffer consumes
premature ejaculation one common male sexual dysfunctions however patients premature ejaculation seeking professional help advice internet become important source knowledge thus patients looking online health information according best knowledge study evaluated content quality websites premature ejaculation therefore aimed evaluate content quality currently available internet based information premature ejaculation sample obtained comprising top sites retrieved google bing yahoo search engines using terms premature ejaculation site reviewed based predefined evaluation criteria determine general quality condition specific content quality popularity index ownership websites reviewed differed highly terms quality ownership sites provided comprehensive medical complete information premature ejaculation online information available often uncertain calibre therefore men exposed information premature ejaculation highly variable degree quality fact considered health professionals website owners better online resources provided patients
transition renewable energy systems fluctuating renewable energy wind solar power plays large important role creates challenge terms meeting demands energy production fluctuates based weather patterns utilise high amounts fluctuating renewable energy energy system flexible terms decoupling demand production paper investigates two potential ways increase flexibility first interconnection energy systems instance two countries labelled cross border interconnection second cross sector interconnection integration different parts energy system instance heat electricity paper seeks compare types interconnectivity discuss extent mutually beneficial study investigates two energy systems represent northern southern europe systems three developmental steps increase cross sector interconnectivity developmental step increasing level transmission capacities examined identify benefits cross border interconnectivity results show measures increase system utilisation renewable energy system efficiency cross sector interconnection gives best system performance analyse possible interaction cross sector cross border interconnectivity two main aspects clarified first part defines approach second construction two archetypes elsevier ltd rights reserved
background sexual reproductive rights include access accurate appropriate information order make informed decisions current age media globalization internet adolescents exposed information sexual health sexuality myriad sources objective study explore sources information adolescent learning sexual health sexuality santiago chile methods data collection included four focus group discussions total adolescents years old semi structured interviews adolescents years old seven interviews key informants working adolescents audio recordings transcribed verbatim analysed using content analysis results primary sources sexual health sexuality information parents teachers friends whilst secondary sources included health professionals females internet males information provided trusted sources parents teachers health professionals tended focus biological aspects sexuality particularly pregnancy sexually transmitted infections limited emphasis placed topics love attraction pleasure relationships abstinence sexual violence information focused primarily heterosexual relations reproduction adolescents learnt relationships sexual acts friends partners many males pornography findings indicate lack available information partner communication setting personal limits contraception including morally neutral medically correct information emergency contraception conclusions study highlights numerous gaps adolescent information needs information provided parents teachers health professionals priority trusted sources place providing biological information overshadows learning emotional relational aspects sexuality biological rationalization adolescent sexual behaviour neglects way gender inequality peer pressure coercion media eroticization religion influence adolescent sexual decision making heteronormativity information excludes sexual orientations disregards diverse spectrum human sexual behaviours finally limited provision practical information hinders development skills necessary ensuring safe consensual pleasurable sexual relations trusted adults encouraged engage adolescents critical reflection broad range sexuality topics dispelling myths building knowledge skills necessary make informed decisions
study aimed investigate formation three inclusion complexes laccaic acid main component lac dye named beta cyclodextrin beta methyl beta cyclodextrin beta hydroxyethyl beta cyclodextrin beta exploring particularly effects cds solubility binding ability final inclusion coitiplexes lac dye natural colorant widely used food textile industry low water solubility application nontoxic dye restricted study employed beta cyclodextrin derivatives encapsulate hydrophobic part resolve aforementioned limitation binding constants solubility determined three beta cds using phase solubility method followed rank order beta beta beta inclusion interactions beta cds detected using fourier transform infrared spectroscopy nuclear magnetic resonance moreover scanning electron microscope transmission electron microscope applied characterize appearance inclusion complexes study would provide useful approach obtaining novel based products high water solubility low toxicity elsevier ltd rights reserved
purpose review well established agerelated increase blood pressure augmented menopause yet prevalence hypertension enhanced low birth weight women relative normal birth weight counterparts years age suggesting adverse influences fetal life heighten cardiovascular risk later life recent findings changing hormonal milieu may contribute increased cardiovascular risk occurs menopausal transition low birth weight associated early age menopause recent study indicates shift towards testosterone excess following early reproductive senescence may contribute etiology age dependent increases blood pressure rodent model low birth weight summary review highlight current findings related postmenopausal hypertension discuss potential mechanisms may contribute enhanced cardiovascular risk develops age low birth weight women
automatic computation surface correspondence via harmonic map active research field computer vision computer graphics computational geometry may help document understand physical biological phenomena also broad applications biometrics medical imaging motion capture industries although numerous studies devoted harmonic map research limited progress made compute diffeomorphic harmonic map general topology surfaces landmark constraints work conquers problem changing riemannian metric target surface hyperbolic metric harmonic mapping guaranteed diffeomorphism landmark constraints computational algorithms based ricci flow nonlinear heat diffusion methods approach general robust employ algorithm study constrained surface registration problem applies computer vision medical imaging applications experimental results demonstrate changing riemannian metric registrations always diffeomorphic achieve relatively high performance evaluated popular surface registration evaluation standards
background aims high protein energy restricted diets demonstrated efficacy promoting weight loss overweight obesity however protein percentage achieves optimal efficacy acceptability remains unknown sought assess effects three energy reduced diets different percentages calories protein weight loss lipids secondary outcomes included diet acceptability compliance methods six month randomized study included women aged years bmi taking lipid lowering drugs randomly assigned women one three calorie reduced diets protein animal protein carbohydrates fat dietary intervention involved individual visits nutritionist every weeks first months performed follow visit months results eighty women aged years bmi completed study months weight loss protein groups respectively figures slightly homogeneously increased months around women following protein diet lost body weight similar protein group significant decreases occurred fat mass lipids insulin resistance especially protein group protein improvement fully explained weight loss triglyceride change negatively correlated animal protein intake groups provided similar responses acceptance palatability satisfaction questionnaire conclusions energy restricted diet protein mostly animal origin effectively impacts cardiometabolic profile energy restricted diet lower protein content although clear benefit diets terms overall weight loss observed high protein diet displayed excellent safety profile acceptability elsevier ltd european society clinical nutrition metabolism rights reserved
flexible manipulator system unwanted vibrations deteriorate usually performance system due coupling large overall motion elastic vibration paper focuses active vibration control two link flexible manipulator piezoelectric materials multi flexible body dynamics mfbd model two link flexible manipulator attached piezoelectric sensors actuators established firstly based absolute nodal coordinate formulation ancf motion equations manipulator system derived motion process dynamic responses system simulated according time varying feature system fuzzy pid controller developed depress vibration controller tune control gains online accommodating variation system control results obtained fuzzy pid control conventional pid control indicate fuzzy pid controller effectively suppress elastic vibration manipulator system performs better conventional pid controller
objective report discusses role congenital acquired risk factors pathogenesis portal vein thrombosis pvt study design describe clinical management treatment pvt preterm newborn homozygous mutation methylenetetrahydrofolate reductase mthfr plasminogen activator inhibitor pai genes sepsis candida parapsilosis results although literature data suggest minor role genetic factors thrombophilia case one mutation hypothesize combined thrombophilic genetic defects may cumulative effect significantly increase thrombotic risk conclusion could appropriate include detailed analyses procoagulant fibrinolytic factors diagnostic workup neonatal thrombosis also investigation genetic polymorphisms anticoagulant therapy removal concurrent risk factors remain basic steps adequate management prevention complications
growing number reports demonstrated widely used herbicide atrazine atr cause injury dopamine neurons exact mechanism remains unclear study examined effects lactational atr exposure sprague dawley rats dopaminergic neuron health later life compared control rats rats exposed atr critical period neural development showed decreased striatal content increased rates turnover expression monoamine oxidase mao associated degradation regulated expression vesicular monoamine transporter vmat associated transport regulated expression transcription factor nuclear receptor related factor nurr associated neuron development regulated increased age months old increased statistical significance differences indicators atr treated rats compared control rats taken together results indicate atr exposure critical neural development period causes regulation nurr turn affects nurr target genes including mao vmat dat involved degradation transport reduced expression genes impairs capacity vesicular storage reuptake causing decreased levels striatal ultimately lead neuron injury neuron injuries become severe time suggests aging synergistically promote atr associated neuron injuries elsevier inc rights reserved
objectives brief version world health organization quality life instrument whoqol bref widely used evaluating personal subjective quality life qol patients particular populations however absence sufficient studies among general population normative data whoqol bref remain scarce fill gap present study explored sociodemographic health related factors affecting qol study design total participants aged years rural areas liaoning province screened stratified cluster multistage sampling scheme anthropometric measurements laboratory examinations self reported information disease history collected trained personnel depression symptoms assessed using patient health questionnaire methods stepwise multiple linear regression used explore association multiple factors qol results females single widowed subjects lower qol scores males married cohabiting subjects respectively total qol scores scores domain decreased age increased positive correlation found age environmental domain score participants higher annual incomes education levels activity levels higher qol scores regression model coefficient stroke confidence interval total qol score one level increase depression level total qol score decreased physical domain score decreased psychological domain score decreased conclusions socio economic status including marital status highly related qol regarding chronic diseases stroke important factor qol depressive symptoms strong negative relationship qol royal society public health published elsevier ltd rights reserved
paget disease bone may predispose development malignant bone tumors osteosarcoma giant cell tumor gct consequence paget disease rare bone gct characterized rapid growth destruction bone extension surrounding soft tissue abnormal bone turnover caused abnormality receptor activator nuclear factor kappa rank rank ligand rankl pathway denosumab rank rankl inhibitor used treat osteoporosis bone gct current study year old male presented severe pain located right thigh knee patient could bear weight affected leg patient suffered paget disease years complications paget disease included degenerative hip disease patient underwent right total hip replacement right periacetabular lesion identified confirmed paget disease induced gct needle biopsy positron emission tomography pet scan revealed significant tumor metabolic activity subsequent obtaining informed consent patient started treatment denosumab total months starting denosumab pet scan showed residual pathological uptake site previously identified large pet avid tumor year patient exhibited satisfactory clinical improvement conclusion treatment denosumab markedly reduced size hemi pelvic gct led complete metabolic response
background young offenders known population high prevalence mental health disorders cases disorders neither identified treated properly majority chronic difficult treat many countries prevalence rates psychopathology male young offenders still unknown psychotherapeutic interventions delivered therefore main goal present study assess mental health problems portuguese male young offenders placed either custodial community based programs discuss treatment implications within juvenile justice interventions methods participants study included male young offenders aged years old randomly selected using random number table total sample participants placed juvenile detention facilities receiving community based programs participants interviewed mini international neuropsychiatric interview children adolescents structured interview assesses dsm axis mental disorders participants aged years older also assessed antisocial personality disorder section structured clinical interview dsm axis personality disorders results results showed high prevalence mental health disorders global prevalence total sample groups global prevalence rates equally high youth custodial versus youth community based programs substance related disorders prevalent youth placed juvenile facilities whereas anxiety mood disorders often found community based group moreover oppositional defiant disorder prevalent youth community whereas antisocial personality disorder conduct disorder less prevalent expected group high comorbidity rate also found majority participants groups fulfilling criteria two disorders additionally participants conduct disorder four times likely fulfill criteria substance abuse conclusions findings inform specific needs concerning mental health intervention taken account deciding planning rehabilitation programs male young offenders either custodial community based programs
paper wave method used designing high order square root domain filters emulate topology corresponding ladder prototypes achieved transposing signal flow graph corresponds wave equivalent elementary two port subnetwork linear domain corresponding one square root domain employing appropriate set complementary operators equivalents reactive elements derived wave equivalent elementary subnetwork interchanging terminals appropriate wave signals using inverters advantage offered proposed technique modularity derived filter configurations example fifth order lowpass square root domain wave filter designed behaviour studied simulation results order demonstrate validity proposed design technique john wiley sons ltd
hepatocyte growth factor hgf pleiotropic cytokine well known regulator mouse embryonic organogenesis previous papers shown expression pattern hgf receptor met different stages testis prenatal development demonstrated met expressed fetal leydig cells flcs hgf stimulates testosterone secretion organ culture late fetal testes present study analyzed proliferation rate apoptotic index differentiation flcs testicular organ culture days postcoitum dpc embryos clarify physiological role hgf late testis organogenesis based data conclude following hgf acts antiapoptotic factor able reduce number apoptotic flcs testicular caspase active fragment hgf affect flc proliferation hgf significantly increases expression insulin like insl marker leydig cell terminal differentiation without affecting beta hydroxysteroid dehydrogenase betahsd expression hgf significantly decreases expression nestin marker leydig cell progenitors hgf significantly increases number fully developed flcs taken together observations demonstrate hgf able act vitro survival differentiation factor flc population
report aim add existing body evidence regarding link anti tumor necrosis factor alpha anti tnf alpha treatment demyelination leading neurological disorders specifically guillain barr syndrome gbs treatment interleukin ila antagonist safe alternative ankylosing spondylitis literature review carried current research concerning anti tnf alpha induced gbs papers published english reviewed peer reviewed journals searched papers published september included animal studies excluded data bases searched publications online included pub med google scholar cochrane library web science searched terms include anti tnf guillain barr ankylosing spondylitis secukinumab tnf alpha adalimumab infliximab etanercept combinations outcomes used searches provisional reference list constructed short listed articles read reference lists reviewed electromyogram done patient showed demyelination mri brain showed pathologies mri spine consistent ankylosing spondylitis without myelopathy lumbar puncture results showed albuminocytological dissociation consistent gbs tnf proinflammatory action various immunoregulatory actions together seem promote development peripheral neuropathies syndromes organism however clear mechanism anti tnf alpha treatment induce demyelinating event patient case presented found patient developed gbs due treatment etanercept anti tnf agent treatment stopped immediately two years later switched secukinumab well controlled last months neurological findings
background irritable bowel syndrome ibs inflammatory bowel disease ibd patients report similar gastrointestinal symptoms yet comparisons symptom severity groups general population lacking methods compared patient reported outcomes measurement information system promis symptom scales measuring gastro esophageal reflux ger disrupted swallowing diarrhea bowel incontinence nausea vomiting constipation belly pain gas bloating usa sample ibs patients iii ibd patients tertiary care community populations symptom severity scores based score metric mean standard deviation relative key results patients enrolled ibs patients mean age years ibd patients mean age years subjects mean age years ibs patients reported greater severity ger disrupted swallowing nausea vomiting belly pain gas bloating constipation symptoms ibd counterparts compared ibd patients worse belly pain gas bloating diarrhea bowel incontinence less severe ger disrupted swallowing ibs patients severe nausea vomiting belly pain gas bloating constipation women severe belly pain gas bloating men whereas men severe bowel incontinence conclusion inferences ibs ibd associated severe symptoms compared excluding esophageal symptoms unlike ibd ibs characterized observable inflammation patients report severe upper lower symptoms
paper explains reason difference maximum torque speed characteristics power factor motor generator operation modes investigates influence machine design parameters difference stator resistance rotor resistance iron loss etc analytical mathematical model based reference frame employed investigation shown difference torque speed characteristics motor generator operation modes mainly caused opposite direction axis current affected stator rotor resistance values finally analytically calculated torque speed characteristics motor generator operation modes verified finite element analyses elsevier rights reserved
mixed findings regarding effects vitamin bone metabolism existed first find negative association serum alpha tocopherol concentration bone mineral density elderly population using vitamin supplement alpha tocopherol promote bone health warranted time aim study examine associations serum vitamin alpha tocopherol gamma tocopherol status bone mineral density bmd among elderly population used data national health nutrition examination survey nhanes cross sectional study finally included subjects liver diseases kidney diseases rheumatoid arthritis cancers treated osteoporosis taking steroids female hormones multivariable linear regression models employed examine associations serum vitamin alpha tocopherol gamma tocopherol concentration bmds total spine femoral neck adjusting covariates potential confounders significant differences serum alpha tocopherol gamma tocopherol levels dietary intake vitamin alpha tocopherol bmds total spine femoral neck presented male female participants serum alpha tocopherol gamma tocopherol concentrations found inversely correlated univariable linear models significant negative associations serum alpha tocopherol total spine bmd beta femoral neck bmd beta found accounting covariates serum alpha tocopherol level negatively associated femoral neck bmd beta study found negative association serum alpha tocopherol concentration femoral neck bmd elderly population suggesting harmful effect alpha tocopherol bone health future studies warranted examine dose response relationships individual vitamin isomers bone metabolism
aims aimed analyse trends annual incidence hospitalized acute coronary syndrome acs france methods results primary diagnosis acs subtypes admissions selected national exhaustive french hospitalization database age standardized rates computed using standardization census european population mean annual percent changes estimated using poisson regression model patients women men hospitalized acs among women proportion aged years stemi nstemi rates age standardized admissions acs women less years old increased rise acs driven significant increases stemi nstemi largest increase stemi mean annual percent change observed among women aged years old per year years age significant decreases acs types observed conclusion nationwide study showed substantial rising trends stemi annual incidence especially among younger women increase could attributed increase smoking obesity efforts strengthen primary prevention cvd younger women needed main risk factors modifiable growing evidence higher short term mortality chd women
singleton merten syndrome mim autosomal dominant inherited disorder characterized early onset periodontitis root resorption osteopenia osteoporosis aortic valve thoracic aorta calcification disorder significant intrafamilial phenotypic variability present mother daughter singleton merten syndrome harboring previously described pathogenic missense mutation arggln ifih interferon induced helicase domain encoding mda melanoma differentiation associated protein data confirm pathogenicity ifih arggln singleton merten syndrome affirm striking phenotypic heterogeneity disorder addition expand singleton merten phenotype adding severe systemic lupus erythematosus sle clinical picture investigations known sle genes well single nucleotide polymorphism suggested involved development sle normal
several government initiatives aim increase availability home community based services efforts helped facilitate transition individuals disabilities living institutions nursing facilities community living resulting improved quality life potential health care savings however evidence suggests lack affordable housing remains key barrier keeps individuals living institutions transitioning community living study evaluated effect transition rates among nursing home residents eligible non elderly disabled housing choice voucher program program provided housing vouchers subsidized rental costs along access home community based services nonelderly institutionalized residents disability assessed program impact likelihood community transitions among target population five areas vouchers made available pooled sample three five areas program increased community transition rates percentage points finding suggests targeting housing vouchers people disabilities living institutions could help facilitate expedite transitions community living
double stranded rna dsrna activated protein kinase pkr ubiquitously expressed serine threonine kinase key inducer inflammation insulin resistance glucose homeostasis obesity recent studies demonstrated pkr respond metabolic stress mice well humans however underlying molecular mechanism fully understood aim present study examine effect high glucose cultured rat muscle cells investigate whether inhibition pkr could prevent deleterious effects high glucose cells pkr expression determined immunofluorescence immunoblotting expression different insulin signaling gene markers measured pcr oxidative stress apoptosis determined flow cytometry high glucose treated muscle cells developed significant increase pkr expression impaired insulin signaling well reduced insulin stimulated glucose uptake observed high glucose treated muscle cells significant increase reactive oxygen species generation apoptosis formation also observed high glucose treated cultured muscle cells effects high glucose attenuated selective pkr inhibitor imoxin study demonstrates pkr may additive role deleterious effects high glucose diabetes prevention pkr activation safer specific inhibitors therapeutic option metabolic disorders needs explored elsevier inc rights reserved
background study assessed direction relationship symptoms insomnia disorder depression various anxiety disorders obsessive compulsive disorder ocd adolescents controlling age gender chronotype outcome variable baseline methods data collected eight high schools adelaide south australia two time points approximately months apart study completed high school students baseline follow respectively aged grades baseline hierarchical regression analyses used assess relationship first model controlling age gender chronotype second controlling outcome variable baseline results insomnia symptoms predicted predicted symptoms psychiatric disorder model model insomnia symptoms predicted symptoms depression vice versa symptoms insomnia also predicted symptoms separation anxiety disorder sad vice versa model symptoms obsessive compulsive disorder ocd social phobia predicted symptoms insomnia disorder model vice versa insomnia symptoms longer related symptoms anxiety disorders model limitations use self report measures potential predisposing precipitating perpetuating preventative factors assessed conclusions symptoms insomnia disorder bidirectionally related depressive symptoms independent baseline symptoms unidirectionally related symptoms ocd ocd independent risk factors development insomnia symptoms
step length estimation important issue areas gait analysis sport training pedestrian localization article estimate step length walking using waist worn wearable computer named ebutton motion sensors within device used record body movement trunk instead extremities two signal processing techniques applied algorithm design direction cosine matrix transforms vertical acceleration device coordinates topocentric coordinates empirical mode decomposition used remove zero first order skew effects resulting integration process experimental results show algorithm performs well step length estimation effectiveness direction cosine matrix algorithm improved walking speed increased
pursuit faster fast track flash track deemed necessary today industry reasons emergency rebuilds competitive market advantage regulatory compliance flash tracking defined time driven project necessity requires heightened degree concurrency engineering procurement construction paper reports flash track readiness assessment algorithms developed enable organization assess readiness execute time critical flash track projects readiness assessment algorithms developed defining relative importance essential flash track practices grouped categories using analytic hierarchy process ahp weights practices categories determined member industry expert panel comprised construction industry institute cii member companies representing owners contractors engineering organizations algorithms ultimately integrated flash track toolkit validation exercise representatives completed flash track projects used toolkit reference projects project representatives retrospective self assessment readiness perform projects flash track basis moderately strongly correlated readiness assessment forecasted research algorithms research provides first quantitative measurement suitable assess organization readiness undertake unique challenges flash track project
background studies assess use non vitamin antagonist oral anticoagulants noacs daily practice prevention thromboembolic complications associated nonvalvular atrial fibrillation objectives describe noacs use analyze prescribing pattern evaluate possible factors associated adverse events aes applicability prescription support forms methods included patients treated noac three primary healthcare centers barcelona spain demographic clinical data collected well embolic bleeding risk reported aes results total patients included median age years noacs frequently prescribed dabigatran rivaroxaban patients receiving recommended dosage potential bleeding risk present subjects ten aes reported eight hemorrhages patients presented years higher proportion concomitant treatment morbidities could prompt bleeding years higher risk bleeding prescription support forms help good prescribing identifying potential individuals high risk aes
path length measuring relevant engineering problem leonardo vinci designed military appropriate equipment podometer modern equipment step meters map meters quite similar vinci design despite geometrical statistical stereological methods based theorems cauchy buffon potentially available long period time better job theorems moreover applied earlier engineering purposes indicated paper even saltikov reintroduction quantitative image analysis purposes ignored gradually last half century stereological methods became popular concrete technology nevertheless stereology based global averaging operation required make step materials technology engineering properties inherent making errors literature demonstrates methodological framework described earlier papers author path length measurements sections cracked concrete ray images steel fibre reinforced concrete sfrc laying side side paper direct engineering approach vinci map meter science stereology based approaches profit economy reliability nevertheless stressed particularly element geometric averaging based simple mathematical statistical notions highlighted literature reflects still major violations scientific principles three dimensional information indicated fields materials engineering also readily obtained provided proper sampling guaranteed
previous studies shown mimicking human hand challenging due fact structure human hand delicate complex robotic hand simple task holding pen requires greater understanding various topics hand mechanics design forward inverse kinematics tactile force sensors actuators control paper new design multifingered robot hand known red hand proposed model red developed using solidworks simechanics red hand consists fingers degrees freedom actuated brushless motor pid controller employed show effectiveness red hand grasping control simulation result showed pid controller satisfactorily controlled joint red hand addition red hand able grasp less seconds without overshoot producing small steady state error
ionospheric total electron content tec derived analyzing dual frequency signals global positioning system gps recorded near indian equatorial anomaly region varanasi geomagnetic latitude degrees geomagnetic longitude degrees studied specifically studied monthly seasonal annual variations well solar geomagnetic effects equatorial ionospheric anomaly eia solar minimum period may april found daily maximum tec near equatorial anomaly crest yield maximum values equinox months minimum values summer using monthly averaged peak magnitude tec clear semiannual variation seen two maxima occurring spring autumn statistical studies indicate variation eta crest tec poorly correlated dst index correlated well index eia crest tec found developed around cospar published elsevier ltd rights reserved
increasing requirements technical products represent growing challenge manufacturing engineering challenge met development new manufacturing technology called sheet bulk metal forming early consideration full potential sheet bulk metal forming design process design engineer know process limitations soon possible hence objective acquire design relevant knowledge already early phases process development maintain knowledge simultaneously development process declared aims self learning engineering assistance system carry acquisition maintenance knowledge owing self learning aspect article within evaluation knowledge acquisition methodologies data mining identified possibility realization self learning aptitude potential data mining shown application simulation data acquire design relevant knowledge
china vast territory includes seven river basins yangtze river basin yellow river basin huaihe basin relevant water resources management agencies made great contributions promote sound rapid economic social development watersheds water resources management involves wide area river basin needs overall planning upper middle lower reaches banks tributaries surface underground water quantity water quality exploitation protection central document central conference irrigation work clearly put forward strict water resources management system february state council issued views implementation strict water resources management system brought new serious challenges river basin water resources management background based comparison river basin water resources management systems home abroad aiming possible solutions weakness china basin region combined management system study provides countermeasures improvement china water resources management following aspects legal system construction management operating system power authority division monitoring ability safeguard mechanism
study series cyclic triaxial tests performed examine undrained dynamic resistance silty sand reinforced various arrangements geotextile layers silt content samples varies percentage total laboratory cyclic triaxial tests performed silly sand samples reinforced geotextile layers different depths tests performed kpa confining pressure subjected isotropic consolidated undrained ciu condition tests conducted frequency results indicate geotextile arrangement silt content essential liquefaction potential reinforced sands increase number geotextile layers enhanced cyclic resistance reinforced samples liquefaction potential also found geotextile layer posited near top specimen load application part liquefaction resistance would increase clean sands improvement liquefaction resistance caused geotextile layer depth sample height times greater geotextile layer inserted mid height sample based obtained results effects geotextile liquefaction resistance decreased fines content increased increase fines content however would lead higher reinforcement advantages liquefaction improvement effective higher number geotextile layers results also revealed reinforcement effect approximate lowest amount
declining mortality led rising number persons living hiv plwh concerns future shortage hiv practitioners develop hiv primary care track internal medicine residents academic hospital community health center history caring plwh lesbian gay bisexual transgender lgbt patients internal medicine residents enrolled four residents annually year track goal provide continuity care least plwh curriculum included small group learning sessions outpatient electives global health opportunity development scholarly project residents successfully accrued plwh continuity patients senior residents passed american academy hiv medicine certification exam graduates took positions primary care involving plwh clinical performance residents hiv care quality measures comparable reported published cohorts developed implemented novel track train medical residents care plwh lgbt patients results suggest designated residency track serve model training next generation hiv practitioners
psychopathy core topic neurobiological research criminal behavior article contains brief overview state knowledge field although hare concept psychopathy pcl contributed much sound research various problems suggest recent multidimensional concepts included also shown pcl better predictor general violent recidivism structured risk assessment instruments core part article addresses neurobiological theories findings psychopathy research suggests psychopaths show deviant levels physiological hormonal neurotransmitter characteristics particular deficits functioning prefrontal cortex limbic system findings fit theories deficits cortical arousal avoidance learning somatic markers emotionality empathy self control attention modulation addition progress basic research psychopathy also promising development regard treatment management psychopaths research deficits future perspectives briefly outlined
currently several embedded applications military industry banking transference commerce biometric systems others use insecure communication channels internet transmit store confidential information therefore integrity security information important issue continuous research last years chaotic systems proposed cryptography due several properties related cryptography properties extreme sensibility initial conditions confusion ergodicity diffusion paper present bit microcontroller implementation improved text encryption algorithm based murillo escobar algorithm real time embedded systems present complete security analysis key size analysis key sensitivity plain text sensitivity floating frequency histograms grams autocorrelation information entropy robustness classic attacks randomness analysis security characteristics addition digital implementation performance analyzed programming details memory required frequency system implementation costs encryption time contrast recent approaches presented literature present complete security analysis statistical implementation level justify proposed scheme real application based results proposed embedded text encryption system secure effective low cost could implemented real time cryptosystem based microcontroller elsevier rights reserved
purpose previous research demonstrated importance emotion recognition ability negotiations leadership scant research investigated role emotion recognition ability service contexts purpose paper propose test compensatory model service employees emotion recognition ability helps enhance job performance particularly employees score low agreeableness personality dimension low cognitive ability design methodology approach two wave multisource dataset collected service center large retail bank multiple regression analysis used test moderating roles agreeableness cognitive ability relationship service employees emotion recognition ability performance findings service employees emotion recognition ability helped enhance job performance however positive effect emotion recognition ability job performance statistically significant employees agreeableness cognitive ability low practical implications findings important implications service organizations select recruit employees particular service employees low agreeableness cognitive ability may still able perform well possessing high emotion recognition ability therefore emotion recognition ability considered selection recruitment process originality value going beyond self report measures emotion recognition using performance measure organizational records study one first examine emotion recognition ability interacts personality cognitive ability predicting service employees effectiveness service organization
many year variations water pollution state two hundred rivers segments different latitudinal zones european russia estimated accordance latitudinal zonality space time trends variations water quality state rivers identified level water pollution river ecosystems segments classified polluted polluted polluted dirty dirty dirty tendency toward water quality improvement could seen recent decade examined river ecosystems transitional state passing natural equilibrium crisis state
background microtia reconstruction intraoperative design cartilage framework important appearance symmetry bilateral auricles templates traditionally ray film template usually utilized complete task provide cues regarding size cranioauricular angle positioning surgeons combination three dimensional scanning additive manufacturing techniques utilized two different ear shaped templates sheet moulding templates fabrication customized autologous cartilage frameworks auricle reconstruction methods forty unilateral microtia patients included study patients underwent auricle reconstruction using tissue expanding technique assisted new templates images processed using computer aided design software exported print two different ear shaped templates sheet moulding templates assisted framework fabrication images patient head captured preoperatively using scanner ray film templates also made patients lengths widths contralateral auricles ray film sheet moulding templates measured triplicate error template contralateral auricle used compare accuracy two templates results january may unilateral microtia patients aged years included study patients underwent auricle reconstruction using autogenous costal cartilage sterilized templates used assist framework fabrication operative time decreased average min compared method assisted ray film template postoperative appearance evaluation based five indexes symmetry length width cranioauricular angle substructure reconstructed ear performed doctors patients parents follow ranging months showed patients obtained satisfactory results life like configuration symmetric cranioauricular angle follow showed surgery related complications occurred comparing accuracy ray film sheet moulding templates average errors length respectively average width errors respectively new sheet moulding template accurate ray template conclusions new sheet moulding template much accurate traditional xray film template framework fabrication assisted accurate informative templates contributed individualized cartilage framework fabrication satisfactory results british association plastic reconstructive aesthetic surgeons published elsevier ltd rights reserved
proposed magnetic fields mfs influence gene transcription via ctct motif located human hsp promoter check universality mechanism estimated potential role motif plant gene transcription response mfs using bioinformatics experimental studies searched potential promoter sequences upstream potato solanum tuberosum thale cress arabidopsis thaliana genomes ctct sequence motif found average times per promoter motifs total two species respectively however ctct sequences randomly distributed promoter regions preferentially located near transcription initiation site closely packed closer ctct sequences transcription initiation site smaller distance plants one assume genes many ctct motifs promoter regions potentially regulated mfs check assumption tested influence mfs gene expression transgenic potato three promoters ugt containing ctct sequences starting expression beta glucuronidase reported gene potatoes exposed min reporter gene activity measured although factors induced reporter gene activity implies ctct motif mediate response tested plant promoters
green eco friendly housing includes approaches reduce indoor air pollutant sources increase energy efficiency although sealing tightening buildings save energy reduce penetration outdoor pollutants adverse outcome increased buildup pollutants indoor sources objective study determine differences indoor air quality iaq green non green homes low income housing complexes one housing complex apartments renovated using green principles home visits conducted immediately renovation subsequently months months following renovation homes eight homes pre renovation home visits allowed pre post renovation comparisons within homes parallel visits conducted non green control apartments nearby low income housing complex iaq assessments included black carbon ultrafine particles sulfur total volatile organic compounds vocs formaldehyde air exchange rate data analyzed using linear mixed effects models none indoor pollutant concentrations significantly different green non green homes however found differences comparing concentrations renovation measured immediately renovation indoor black carbon concentrations significantly lower averaging post renovation pre renovation home visits contrast formaldehyde concentrations significantly higher post renovated ppm pre renovated homes ppm questionnaire data showed opening windows occurred less frequently homes immediately post renovation compared pre renovation factor likely affected levels indoor black carbon outdoor sources formaldehyde indoor sources renovation status reduce iaq problems potentially improve health careful selection indoor building materials ensuring sufficient ventilation important green building designs elsevier rights reserved
dynamic simulation transient stability assessment one important intensive computational tasks power system planning operation several commercial software tools provide functionality performing multiple dynamic simulations contingency analysis simultaneously parallel computers nevertheless single dynamic simulation still time consuming process performed sequentially one single computing core tools originally designed modern high performance computing hpc holds promise accelerate single dynamic simulation parallelizing kernel algorithms without compromising computational accuracy parallelizing single dynamic simulation much challenging problem contingency type parallel computing requires good match simulation algorithms computing hardware paper provides guidance match design implement parallel dynamic simulation maximize utilization computing hardware performance simulation guidance derived comparative implementation four parallel dynamic simulation schemes two state art hpc environments message passing interface open multi processing scalability speedup performance parallelized dynamic simulation thoroughly studied determine impact simulation algorithms computing hardware configurations several testing cases presented illustrate derived guidance
although frontal presentations alzheimer disease already described literature still know little patients social cognitive abilities especially theory mind tom report case year old woman diagnosed two assessments social cognition using false belief task reading mind eyes test task probing knowledge social norms performed one year apart exhibited cognitive tom social knowledge deficits onset affective tom initially preserved deteriorated disease progressed
non suicidal self injury nssi highly prevalent associated tissue damage emotional distress psychiatric disorders often discussed context borderline personality disorder suicide research demonstrates nssi distinct constructs viewed independent diagnostic category recently non suicidal self injury disorder nssid included revised diagnostic statistical manual mental disorders condition study article describe properties self report measure designed assess proposed criteria nssid undergraduate students large public universities completed nssid scale nssids along measures nssi characteristics psychopathology among participants history nssi approximately half met diagnostic criteria nssid participants frequently excluded nssid diagnosis basis criterion frequency nssi criterion distress impairment related nssi participants least likely excluded diagnosis basis criterion nssi method exclusions criterion diagnostic rule outs consistent previous literature commonly reported precipitants nssi negative feelings thoughts criterion participants met criteria nssid reported severe depression anxiety nssi participants engaged nssi meet criteria nssid results support use nssids reliable valid self report measure nssid symptoms
recent results related investigation role intestinal microbiota development functioning human nervous system discussed role microbiota bidirectional communication gastrointestinal tract central nervous system considered special attention paid primary infants actively involved formation immune physiological mechanisms including nervous system responsible subsequent general psychical health human results research ability commensal intestinal microflora produce neuroactive compounds including neurotransmitters short long chain fatty acids gamma aminobutyric acid etc summarized compounds may considerable effect development functioning central nervous system including brain research various animal models discussed including investigation effect behavior learning abilities memory anxiety depression levels reaction emotional stimuli stress resistance special section deals probiotic bacteria presently considered psychobiotics preventive therapeutic potential treatment neurological neurophysiological disorders development new paradigms concepts rejection classical concepts neurobiology presently key condition future breakthrough investigation human nervous activity
jak mutation detected high frequency patients myeloproliferative neoplasms mpn mpn treatment efficiency assessed jak quantification real time quantitative pcr qpcr widely used jak quantification emerging alternative technologies like digital droplet pcr ddpcr described overcome inherent qpcr limitations purpose study evaluate utility ddpcr jak quantification patient samples mpn sensitivity specificity established using dna artificial mixtures addition samples patients evaluated jak mutation limit detection qpcr ddpcr jak mutation detected patients pcr platforms however samples jak mutation detected ddpcr discrepant samples patients shortly allogeneic stem cell transplantation percentage jak mutation measured qpcr ddpcr clinical samples showed high degree correlation spearman excellent agreement assessed bland altman analysis conclusion ddpcr suitable precise sensitive method quantification jak mutation
purpose reviewasthma exhibits significant heterogeneity occurrence severity lifespan goal discuss recent evidence regarding determinants natural history asthma childhood review rationale behind status major efforts alter course recent findingsvariations microbial exposures associated risk allergic disease use bacterial lysates may promising preventive strategy exposure air pollution appears particularly damaging prenatal early life interventions reduce pollution feasible result clinical benefit cigarette use may role harm reduction conventional cigarette smokers asthma undefined short term long term effects must clarified vitamin insufficiency first several years life associated risk asthma vitamin supplementation reduces risk severe exacerbations summarythe identification risk factors asthma occurrence persistence severity continue guide efforts alter natural history disease reviewed several promising strategies currently investigation vitamin supplementation air pollution reduction shown effective strategies warrant increased investigation implementation
study looks impact exposure natural disasters pregnancy educational outcomes north carolina children third grade level broad literature relates negative birth outcomes poor educational performance number recent studies examined effect prenatal exposure natural disasters birth outcomes study takes next step considering prenatal exposure affects later outcomes combining north carolina administrative data births school performance disaster declarations federal emergency management agency fema allows identification children exposed disasters prenatal development children compared children born county exposed disasters utero regression results suggest children exposed hurricanes prenatally lower scores third grade standardized tests math reading exposed flooding tornadoes also somewhat lower math scores additionally results suggest negative effects concentrated among children disadvantaged subgroups especially children born black mothers however evidence exists effects mediated common measures birth outcomes including birth weight gestational age
elastodynamic boundary integral equation method biem real space temporal domain accurate semi analytical tool investigate earthquake rupture dynamics non planar faults however heavy computational demand historic integral generally increases time complexity number time steps elements due volume integration causality cone study introduce efficient biem termed fast domain partitioning method fdpm enables reduce computation time order surface integral without degrading accuracy memory requirement also reduced fdpm uses physical nature green function stress partition causality cone domains wave fronts domain wave fronts domain static equilibrium latter two domains exhibit simpler dependences time space scalability method demonstrated large scale parallel computing environments distributed memory systems also shown fdpm enables efficient use memory storage makes possible reduce computation times previously unprecedented level thus present fdpm powerful tool break current fundamental difficulties running dynamic simulations coseismic ruptures earthquake cycles realistic conditions fault geometries
abundance seasonal trophodynamics specific growth rate daily production grazing mortality major picophytoplankton components synechococcus cyanobacteria syn picoeukaryotes pico studied three stations sevastopol bay adjacent coastal waters black sea flow cytometry dilution method pico abundance shown increase along nutrient pollution gradient coastal waters outside bay annual average cells eastern corner bay cells relation found water pollution status syn abundance cells stations matter flows communities daily production syn pico day respectively grazing mortality syn picoe day respectively comparable even exceeded biomass stocks syn picoe respectively indicating high biomass turnover rates highest flow stock ratio syn significant imbalance daily production grazing mortality observed polluted eutrophic waters bay spring pico black river inflow bay hypothesized among mechanisms maintaining pronounced long term imbalance open system without negative consequences picophytoplankton assemblages
linear stability analysis performed base state solution describing pneumatically transported system inclined angle theta one two modes found dominant depending tilting angle low shear mode whose voidage eigenmode remains nearly symmetric degrees thetatheta marked significant asymmetry throughout domain high level shear inside thin regions adjacent walls critical angle theta increases amount momentum energy lost particle wall friction collisions respectively time evolution latter mode superimposed onto base state solution reveals alternating train dense dilute regions near top domain agrees qualitatively development propagation bubbles inclined systems observed experiment analytic solution corresponding vertical system uniform base state also derived identify instability mechanisms responsible class non oscillatory transverse waves exist vertical tilted particle systems american institute chemical engineers
backgroundfish one allergenic foods clinical cross reactivity among different fishes widely accepted feature fish allergy associations food allergies well understood study aims analyzing relevance clinical cross reactivity fish chicken meat patients allergy chicken meat without sensitization hen eggs methodspatients food allergy fish chicken meat chicken meat recruited ige reactive chicken proteins identified edman analysis quantified elisa allergens used ige elisa skin testing resultschicken parvalbumin two new allergens aldolase enolase identified kda respectively recognized sige patient sera majority cases positive fish homologues well fish chicken meat allergens highly cross reactive high inhibition rates fish chicken allergens correlated patients primary sensitization fish chicken cooked roasted foods enolase aldolase detectable chicken breast parvalbumin detectable chicken legs wings conclusionsfish chicken meat cross reactive foods fish allergic chicken meat allergic patients might risk developing food allergy chicken meat fish respectively clinical phenomenon proposed termed fish chicken syndrome cross reactive allergens involved parvalbumins enolases aldolases
intellectual disability affects population male gender bias least genes currently linked identified chromosome including kiaa kiaa located expressed developing brain protein product kiaa linked intellectual disability protein related neurite extension xpn developmentally regulated involved neuronal migration cell adhesion clinical manifestations loss function kiaa mutations described previously males born unaffected carrier mothers females using whole exome sequencing identified cohort five unrelated female patients novo probably gene damaging variants kiaa core phenotypic features developmental delay epilepsy refractory treatment impaired language similar severity reported male counterparts study supports kiaa novel cause linked dominant broadens phenotype kiaa mutations
bidirectional reflectance distribution function brdf one fundamental concepts diverse fields multidimensional reflectometry computer graphics computer vision brdf manifolds form infinite dimensional space typically available measurements scarce therefore efficient learning strategy crucial performing measurements paper perform simulation studies within mathematical framework allows establish efficient brdf sampling measurement strategies sense statistical design experiments generalized proactive learning simulation studies suggest default brdf measurement strategy suboptimal wide class loss functions elsevier ltd rights reserved
bleeding pattern second consecutive levonorgestrel releasing intrauterine system lng ius use consecutive use lng ius associated predictable bleeding pattern characterized absence initial period irregular bleeding seen interval insertion lng ius non bleeding pattern vast majority women increased popularity lng ius long term birth control treatment heavy menstrual bleeding hmb consecutive use system becoming frequent one previous study showed amenorrhea rate consecutive ius users however sample size small prospective multicenter study four european countries recruited women wished continue lng ius use immediately first year period total women followed end first year second ius thereafter women continued extension phase study full years use second ius women continued end study total women mean age years using first lng ius years months years months either contraception treatment hmb planned replace device new lng ius recruited followed years second ius use total centers four european countries involved study bleeding patterns analyzed using daily bleeding diaries using day reference periods first year second ius use last year years use approximately women free bleeding years amenorrheic slight increase number bleeding spotting days similar days first immediately placement second ius whereafter number bleeding spotting days returned level preceding second ius insertion absence bleeding associated high overall satisfaction continuation rates serious adverse events assessed related lng ius use occurred year period cumulative expulsion rate year study period sample size large enough study bleeding patterns subjects likely represent typical consecutive ius users therefore role chance small women represent selected group already successfully used first ius almost years willing continue use however currently common clinical situation results may therefore extrapolated first time users lng ius data importance counseling women making decisions concerning long term contraception
study explored use self assessments journaling peer sharing online computer programming course conducted experiment using pretest intervention posttest design undergraduate first year students participated aimed investigate whether self assessment journaling peer sharing facilitate students learning moreover examined research variables related learning achievement therefore experiment prior knowledge learning performance achievement assessed online logs representing learning behaviors analyzed students interviewed results demonstrated self assessment journaling peer sharing effectively facilitated learning students cognition regulation strategies namely keeping learning journal enabled students summarize key concepts elaborate ideas reflect learning material self assessment allowed students reflect understanding material study peer sharing enabled students study peers learning journals self assessments improve although self assessment journaling peer sharing significantly correlated learning achievement results showed keeping learning journal strongest effect learning achievement moreover self assessment keeping learning journal complemented combining two resulted even higher learning achievement scores findings suggest use self assessment journaling peer sharing show promise facilitate learning online course
backgroundthere controversial information outcome school age individuals lose diagnosis autism achieve optimal outcome present study assessed autism symptoms psychiatric disorders group children past history autism methodsthe subjects consisted individuals lost diagnosis autism years previously clinical assessment done parents children diagnostic statistical manual mental disorders edn dsm criteria used diagnosis autism spectrum disorder asd addition childhood autism rating scale social communication questionnaire current version used psychiatric disorders assessed using kiddie schedule affective disorders schizophrenia school age children present lifetime version sads resultsnone participants met criteria asd ninety two percent lifetime diagnosis present psychiatric disorder based sads attention deficit hyperactivity disorder specific phobia obsessive compulsive disorder common disorders conclusionsimproved status regard autism symptomatology maintained time individuals vulnerable developing psychiatric disorders crucial maintain psychiatric follow children move autism spectrum
aim article systematically review literature studying association television viewing children executive function academic performance attention language play using keywords television children infants attention language education cognition five online databases searched seventy six studies met inclusion criteria reviewed findings suggest relationship television viewing children development complex first likely effects television may depend children individual characteristics family social context second features television content editing pace type exposure foreground background may affect outcomes specifically watching high quality educational content preschool years improves children basic academic skills predicts subsequent positive academic performance conversely television viewing infancy disruptive play reduces quality quantity child parent interactions associated inattentive hyperactive behaviours lower executive functions language delay least short term remains unclear whether interactions television cognition long lasting future research focus systematic investigation pathways link particular components television type exposure individual contextual factors investigate potential unique combined effects development researchers must also address challenge investigating diverse rapidly changing technologies current generation children exposed elsevier inc rights reserved
rheumatoid arthritis associated increased vascular calcification although rate progress calcification uncertain aim study evaluate progression predictors calcification different vascular beds years year actual coronary calcium score year predicted coronary based pattern general population compared calcification coronary carotid artery aorta assessed multi detector computed tomography significant progression determined difference square root baseline square root follow calcium score sqrt method year predicted coronary based mathematical formula derived heinz nixdorf recall study total patients years female follow scan years vascular beds significantly increased patients significant progression coronary carotid aorta age systolic blood pressure sbp independently associated calcification progression vascular beds importantly absolute increase year actual coronary significantly higher predicted patients calcification vascular beds significantly increased years independently associated age sbp importantly absolute increase year actual coronary progression significantly higher predicted
electrical engineering use various analytical tools circuit analysis one possible method analysis means signal flow graphs analysis electronic circuits using graph detail described derived models graphs passive elements known amplifier structures however described transformer models circuit element mutual inductance article derived signal flow graph transformer therefore
frequent inundation become serious problem urban areas necessary improve rainwater retention infiltration urban watershed purpose study report private rainwater retention harvesting facilities spread gradually steadily city citizen initiated activities rainwater harvesting tanks installed intensively rainwater harvesting house constructed city fukuoka japan city experienced flood disaster former enhanced users daily preparedness emergency latter inspired construction rainwater harvesting housing complex public elementary school use april inspired facilities school premises located land reclaimed old irrigation pond thus school needs adapted condition rainwater retained within premises amounts retention discharge monitored data utilized science education big cities people tend depend much top mega system invites impervious surfaces urban areas bottom individual collaborative approaches adopted order achieve multiple purposes preventing mitigating disasters preserving conserving ecosystems nurturing rebuilding communities city elsevier ltd rights reserved
objectiveto identify risk factors suicide attempts individuals commencing treatment manic mixed episode methoda total manic mixed cases bipolar disorder type recruited european countries included prospective year observational study poisson regression models used identify individual treatment factors associated new events two multivariate models built stratified presence absence prior resultsa total recorded prospectively peak incidence weeks commencing treatment cases prior history risk repetition associated younger age first manic episode rapid cycling history alcohol substance use disorder number psychotropic drugs prescribed initiation anticonvulsant study entry cases previous first event associated rapid cycling lifetime history alcohol use disorder initiation anticonvulsant study entry conclusionthe introduction anticonvulsants recent onset manic mixed episode may associated increased risk studies must determine whether link causal
order research application nano concrete reduce roughness coefficient considering roughness coefficient calculating fundamental issues hydraulic engineering also analyzing correct evaluation flow rate interaction hydraulic parameters velocity shape type section flow pattern one important problems fluid mechanics considering possibility minimizing roughness designing hydraulic structures irrigation networks order increase velocity flow rate different sections subjects noted researches industrial entrepreneurs since years ago author article done series experiments effects using silicate nano particles floor coating channels studied hydraulic laboratory flume experimental research could known adding nano silicate concrete mixture cause active sio mix free calcium hydroxide available micro holes concrete produce unsolved calcium silicate eventually cause structure cement become dense become less penetrable causing concrete resistant using product produce smooth homogenous surfaces upper surface increase flow rate velocity fluid channels clarifiers crests dams
date early intervention programs based emotion regulation strategies address dysfunctional cognitive appraisals problem solving sldlls rumination another emotion regulation strategy acceptance training largely overlooked examine efficacy strategy school based mental health program combining positive psychology acceptance commitment therapy strong minds evaluated randomized controlled trial sample year high school students sydney australia mixed models repeated measures examined whether program led reductions symptoms amongst students commenced program high depression anxiety stress scores increased wellbeing scores amongst students results demonstrated compared controls participants strong minds condition elevated symptom scores reported significant reductions depression stress composite depression anxiety symptoms medium strong effect sizes cohen respectively increased wellbeing total sample decreased anxiety scores students elevated symptoms significant year students medium effect sizes cohen respectively study tentatively suggests including emotion regulation strategy acceptance early intervention programs may effective reducing symptoms improving wellbeing high school students research investigate generalizability findings warranted society study school psychology published elsevier ltd rights reserved
although bariatric surgery effective treatment severe complex obesity less known psychosocial impact systematic review synthesizes qualitative studies investigating patient perspective living outcomes surgery total records screened studies included data extraction thematic synthesis yielded three overarching themes control normality ambivalence evident across eight organizing sub themes describing areas life impacted surgery weight activities daily living physical health psychological health social relations sexual life body image eating behaviour relationship food throughout areas patients striving control normality many changes experienced positive led feeling control normal negative changes also experienced well changes neither positive negative nonetheless challenging required adaptation thus participants continued strive control normality aspects lives considerable time contributing sense ambivalence accounts life surgery findings demonstrate importance long term support particularly psychological dietary help people negotiate challenges maintain positive changes achieved bariatric surgery
hypothalamus pituitary adrenal hpa axis end product cortisol essential adequate response stress considering role stress risk factor psychiatric disorders surprising cortisol stress reactivity frequently investigated patients versus healthy individuals however large heterogeneity measures cortisol stress response hampered systematic evaluation evidence report systematic literature review meta analysis cortisol reactivity psychosocial stress across psychiatric disorders original data authors obtained construct standardized cortisol outcomes areas curve respect increase auci ground aucg examine influence sex symptomatic state cortisol stress reactivity fourteen studies major depressive disorder mdd anxiety disorders including social anxiety disorder sad posttraumatic stress disorder panic disorder mixed samples anxiety disorders schizophrenia included used trier social stress test equivalent psychosocial stress task sex dependent changes stress reactivity apparent mdd anxiety disorders specifically women current mdd anxiety disorder exhibited blunted cortisol stress response whereas men current mdd sad showed increased cortisol response psychosocial stress individuals remitted mdd altered cortisol stress reactivity less pronounced women absent men schizophrenia cortisol stress reactivity blunted men women number studies limited showed evidence publication bias findings illustrate sharing individual data disentangle effects sex symptom levels factors essential understanding alterations cortisol stress reactivity across psychiatric disorders elsevier ltd rights reserved
purpose review according endocrine society clinical practice guideline published june testosterone replacement therapy trt administered men hypogonadal documented low testosterone level two morning measurements recommendation based previous studies show increased risk cardiovascular events trt contrast recent studies show increased risk prompted fda investigate recent findings multiple studies suggested increased risk cardiovascular events among groups men prescribed trt summary recent evidence trt associated higher cardiovascular risks risks still well established well designed trials needed physicians always cautious prescribing trt patients potential risks discussed patient trt requires regular monitoring help minimize side effects
catechol methyltransferase comt inactivates catecholamines val val genotype associated increased amygdala amy response negative stimuli influence symptoms severity outcome bipolar disorder probably mediated comt polymorphism interaction cortical subcortical dopaminergic neurotransmission aim study explore implicit emotional processing negative emotional stimuli could interact affecting amy connectivity bipolar depression forty five patients met carriers val val underwent fmri scanning implicit processing fearful angry faces explore effect strength functional connectivity amygdalae whole brain val val met carriers significantly differed connectivity amy dorsolateral prefrontal cortex dlpfc supramarginal gyrus val val patients showed significant positive connectivity areas met carriers presented significant negative one connection dlpfc amy findings reveal comt genotype dependent difference corticolimbic connectivity affective regulation possibly identifying neurobiological underpinning clinical prognostic outcome specifically worse antidepressant recovery clinical outcome previously detected val val patients could associated specific increased sensitivity negative emotional stimuli elsevier masson sas rights reserved
paper presents high accuracy high bandwidth current sense circuit digitally controlled buck converters circuit uses lossless inductor dcr current sensing sigma delta modulator adc sense average current inductor high accuracy accurate low bandwidth measurements unsuitable use feedback control loops acquisition delay would limit achievable loop bandwidth solve issue kalman filter estimates inductor current switching frequency converter output estimator shown experimental results achieve static current accuracy used buck converter switching mhz using power efficient inductor dcr ohms
epstein barr virus ebv large lymphotrophic dna virus establishes life long residency infected host associated number human tumors ebv genome encodes proteins essential persistence oncoprotein proteins render vulnerable host immune system therefore ebv gene transcription tightly regulated one critically important regulatory mechanism utilized ebv dna methylation methylation cytosines within cpg dinucleotides promoter regions important gene silencing genome integrity although parasitic elements methylated mammalian cells never reactivated ebv evolved utilize dna methylation maximize persistence cloak immune detection ebv reliance dna methylation also provides unique therapeutic strategy treatment ebv associated tumors dna demethylating agents capable reactivating transcription highly immunogenic viral proteins rendering tumor cells susceptible killing host immune system inducing viral lytic cycle culminates cell lysis elsevier inc rights reserved
objective date factors contributing emergence resilience different stages adolescence yet sufficiently examined study looks influence extracurricular activities resilience method sample consists adolescents reporting personal problems mood concentration problems behavior effect extracurricular activities resilience gathered analyzed linear regression models predictor variables models extracurricular activities sport hobbies club memberships household duties subscales sdq strengths difficulties questionnaire lack homoscedasticity two different regression models model realschule grammar school model hauptschule specified results explained variance models model model satisfactory models prosocial behavior sdq turns significant positive predictor resilience model beta model beta emotional symptoms model beta model beta significant negative predictors resilience addition model presents significant positive influences sport beta significant negative influences hyperactivity sdq contrast model club memberships beta peer relationship problems beta additional positive predictors conclusions results study demonstrate important role prosocial behavior emotional competence manifestation resilience effect extracurricular activities proves depend social environment type school thus results could form basis specific developmental programs
aims objectivesto investigate relationship quality life social support female nurses backgroundnurses play important role providing care managing patients health hospitals however limited studies shown association quality life social support female nurses china designquestionnaire survey methodsto investigate full time female nurses different departments four comprehensive hospitals harbin cross sectional correlational design using questionnaires demographic data questionnaire menopause specific quality life questionnaire social support scale used resultsthe scores physical psychological subscales higher vasomotor sexual subscales quality life average score objective support higher subjective support utilisation social support significant association quality life social support found conclusionssocial support influenced quality life social support buffer pressure influence individual stress perception help individuals cope pressure reduce negative impact stress mental physical health thus improving different aspects health relevance clinical practiceenhancing social support active environment would allow female nurses enjoy better quality life clinical practice
games received full attention requirements engineering community scenario becoming critical move towards newer forms games pervasive games pervasiveness quality distinguishes pervasive games traditional digital games holds several meanings including ubiquitous permeating something spreading something somewhere physical space pervasiveness recognized boundaries game expanding every time played virtual fictional world real world pervasive games new form digital entertainment evolved different forms alternate reality games transmedia games crossmedia games sensor technologies networking capabilities augmented reality systems computer vision technology internet especially mobile devices responsible rapid evolution new form digital product paper focused pervasive mobile games define context aware games use mobile devices bear mind mobile devices currently main driver fulfilling promises pervasive game playing investigations experiments class games led study quality requirements pervasive mobile games using different information sources gathered set interrelated characteristics crucial success games paper begin clarify definition scope pervasive mobile games controversial issues literature using fundamentals propose two level conceptual map non functional requirements helps realize pervasiveness pervasive mobile games non functional requirements associated set questions help designers verifying tasks operationalizing requirements game also propose dependence matrix pervasive game qualities enhances insight pervasiveness reveals important guidelines game designers
reachability standard fractional order continuous time systems constant inputs addressed positive non positive continuous time linear systems considered necessary sufficient conditions existence constant inputs steers system zero initial conditions given final state desired time derived proved example systems electrical circuits voltage sources presented
home building automation systems hbas becoming widespread adoption distinct users interact systems intentions likely different often resulting conflicting situations systems ought recognize resolve automatically work aims investigating conflict hbas creating solution detect resolve herein review literature concerning conflict detection resolution propose formal framework based constraint solving enables detecting solving conflict situations automatically elsevier rights reserved
background purpose spreading depolarizations sds may contribute delayed cerebral ischemia subarachnoid hemorrhage sah tested whether inhibitor valproate reduces brain injury sah rat model without experimental induction methods rats randomized design pretreated valproate vehicle weeks sah induced endovascular puncture right internal carotid bifurcation one day post sah brain tissue damage measured weighted magnetic resonance imaging followed cortical application mol kcl induce sds nacl sds magnetic resonance imaging repeated day followed histology confirm neuronal death neurological function measured inclined slope test results groups kcl application lesion growth days valproate treated versus vehicle treated group groups without induction lesion growth valproate vehicle treated groups versus fitting way analysis variance model found significant interaction effect treatment kcl nacl application number duration sds mortality neurological function statistically significantly different groups lesion growth magnetic resonance imaging correlated histological infarct volume spearman rho areas lesion growth exhibiting reduced neuronal death compared primary lesions conclusions rat sah model valproate treatment significantly reduced brain lesion growth kcl application future studies needed confirm protective effect based inhibition
homogeneous charge compression ignition hcci double fuel combustion represent two innovative processes sharing strong potential pollutant emissions fuel consumption reduction hcci regards auto ignition homogeneous premixed charge air fuel featuring low nox emissions good efficiency double fuel instead indicates simultaneous combustion gasoline natural gas gasoline lpg premixed air port injection fuels within engine cycle since fuel mixtures enhances hcci performances widening range possible operating conditions authors tested hcci combustion process using natural gas gasoline mixtures cfr engine endowed two injection systems accurate control fuel mixture composition overall air fuels ratio stable knock free hcci combustions obtained combining different intake temperatures compression ratios range engine load maximum load obtained normal spark ignition operation noticeable increment engine efficiency strong reduction pollutant emissions found comparison operation terms nox reduced order magnitude elsevier ltd rights reserved
recently food allergies mammalian meats considered rare observation patients previously exposed monoclonal chimeric antibody cetuximab suffered severe anaphylaxis upon first exposure led identification galactose alpha galactose new relevant carbohydrate allergen patients later often suffered anaphylactic reactions red meat epidemiological data indicated bites tick amblyomma americanum usa later also ixodes species continents resulted sensitisation alpha gal hand african patients parasitic disorders high prevalence anti alpha gal ige without clinical relevance reported four cases one patient late onset meat allergy history tick bite three patients symptoms childhood juvenile age indicates patients ways sensitisation may also take place however patients without atopy tick bite induced ige alpha gal may relevant diagnosis based history delayed onset anaphylaxis skin tests commercially available meat test solutions often equivocal negative skin tests raw meat particularly pork kidney sensitive determination specific ige alpha gal commercially available highest sensitivity observed skin basophil activation tests cetuximab however limited high costs
course computer operating system requires students understand interactions computer systems users hardware platform paper concentrates problem using virtualization technology computer operating system teaching particularly virtualization technology designed simulate real computer hardware environment make operating system run virtual computer environment virtual machine software simulate real computer hardware equipment several operating systems supported microsoft windows linux unix etc main idea paper utilize vmware software operating system teaching vmware provides completely virtualized set hardware specific operating system afterwards discuss design implement experimental platform multiple operating systems based vmware
norbenzomorphans exhibit high affinity sigma sigma receptors varying position substituents aromatic ring scaffold significant effect subtype selectivity particular compounds bearing several different substituents norbenzomorphan ring system exhibit general preference sigma receptor whereas corresponding substituted analogues preferentially bind sigma receptor findings suggest norbenzomorphan scaffold may unique chemical template easily tuned prepare small molecules use tool compounds study specific biological effects arising preferential binding either sigma receptor subtype absence structural characterization data sigma receptor compounds useful toward refining pharmacophore model binding site
article focuses exploring students understanding concept function concerning three main aspects secondary students ability define concept function present examples functions solve tasks asked recognize interpret concept function presented different forms representation solve function problems confirmatory factor analysis verified dimensions comprising conceptual understanding functions definition recognition interpretation problem solving furthermore important role ability define concept rest abilities revealed leading important didactic implications
sexual coercion college campuses become major concern recent decades recent years researchers policy makers called greater attention topic order reduce sexual violence college campuses recent research examined impact family origin experiences perpetration sexual coercion current study examines association family origin experiences warmth hostility parents inconsistent parenting overparenting childhood perpetration sexual coercion among emerging adult males examining feelings entitlement possible mediator data male undergraduate students analyzed using structural equation modeling results show warmth hostility parents significant association parenting behaviors overparenting inconsistent parenting hostility parents associated perpetration sexual coercion offspring young adulthood males also findings suggest overparenting inconsistent parenting childhood directly associated perpetration sexual coercion emerging adulthood strongly related feelings entitlement turn found associated perpetration sexual coercion males results important implications family life education including relationship parenting education future research
year old man complains minor urgency frequency day nocturiax dre reveals benign prostate started tamsulosin daytime symptoms resolve entirely however still nocturia counseled lifestyle modifications decrease fluid consumption including caffeine improvement nocturia cystoscopy normal evident visual obstruction urinalysis normal pvr normal sized neck snore trouble sleeping awakens urge void bothersome
studied associations maternal history eating disorders eds diet quality pregnant women infants breastfeeding practices included mother child pairs generation population based cohort netherlands maternal history lifetime eds assessed pregnancy questionnaire dietary intake pregnancy infancy assessed food frequency questionnaires diet quality scores calculated reflecting adherence dietary guidelines breastfeeding practices assessed questionnaires months observed adjustment socioeconomic lifestyle factors women history eds higher diet quality women without history eds mothers history eds less likely breastfeed unadjusted although longer statistically significant adjustment findings suggest mothers history eds seem slightly less likely initiate breastfeeding however warrants investigation age year infants mothers history eds higher diet quality conclude mothers history eds infants relative good diet quality although follow studies needed assess long term associations diet later childhood adolescence elsevier ltd rights reserved
electric hybrid electric vehicles hev seem future transport smart cities key total reduction noise disturbance pollution urban areas however several problems solved guarantee safety types vehicle use hev shown dangers quiet transport system urban environments fact estimated hev twice likely involved pedestrian crash would internal combustion engine ice vehicle situation aim improving safety different kinds warning sounds designed increase detectability hev without becoming new annoying sound sources sound directivity frequency emission intensity warning sound systems guarantee efficiency limited noise impact several research works bring fore significant variation pedestrian response time different acoustic stimuli however necessary examine suitability warning sounds according urban environments going emitted distinct areas inside city different soundscapes whose spectral content vary significantly masking sounds suggested alert paper analyses detail main characteristics several warning sounds proposed industry conducting comparative study different design trends total sighted listeners exposed virtual road crossing test behaviour appropriateness warning sounds analysed depending urban environment purpose three clearly different soundscapes selected stopped vehicles traffic light pedestrian shopping area vicinity playground results highlight wide variability pedestrian reaction time different warning sounds used signals considerably improve detectability vehicle providing results even ice vehicle ones however warning sounds decrease reaction time respect addition clear dependence observed detectability soundscape involved changing results warning sound depending acoustic environment elsevier ltd rights reserved
nowadays graphene considered one important achievement consequence high potential nanotechnologyand development new environmental energy processes reciently graphene receiving great attention area photocatalysis emerging next generation photocatalysts tool enhancing photocatalytic performance solar photoefficiency titanium dioxide hybridization graphene effect band gap energy decrease shifting absorption threshold visible light region allowing harness solar energy conjugation graphene semiconductor solid particles tio results photocatalysts improved charge separation reduced recombination photogenerated electron hole pairs increased specific surface area introduces adequate quantity quality adsorption sites given enhances electronic optoelectronic electrocatalytic photocatalytic properties critical review sumarizes recent progress design synthesis graphene based titania semiconductor photocatalysts moreover applications wastewater treatments disinfection air pollution control also discussed finally perspectives challenges considered essential extend photoefficiency new photocatalysts visible region harvest directly solar light suggested introduce elucidate new improvements environmental photocatalytic processes elsevier rights reserved
dihydroxyphenylalanine dopa remains primary pharmacological agent symptomatic treatment parkinson disease however development dopa induced dyskinesia lid limits long term use dopa patients data reported adenosine receptor antagonists prevented lid animal model however mechanism adenosine blockade alleviates symptoms lid fully clarified determined knock gene explored possible underlying mechanisms implicated development lid mouse model gene mice unilaterally injected striatum hydroxydopamine ohda order damage dopamine neurons one side brain ohda lesioned mice injected daily days dopa abnormal involuntary movements aims evaluated days dopa administration real time polymerase chain reaction immunohistochemistry glutamic acid decarboxylase gad gad performed found gene effective reducing aim scores accompanied decrease striatal gad rather gad results demonstrated possible mechanism involved alleviation aim symptoms gene might reducing expression striatal gad
objectives hypothesisto investigate point prevalence sad degrees anxiety depression sleep disturbance characteristics tinnitus patients chronic tinnitus study designcross sectional survey study methodsfrom december february patients chronic persistent intermittent tinnitus months enrolled audiograms tinnitograms visual analogue scales vas used assess tinnitus tinnitus handicap inventory thi assessment questionnaires anxiety depression sleep disturbance sad administered resultsthe male female ratio mean age years numbers patients suspected sad subsyndromal sad sad nine respectively winter uncomfortable season nine patients catastrophic thi score sad group sad group control group suggesting significant correlation sad sad thi audiogram tinnitogram vas assessment sleep disturbance testing revealed significant differences among three groups anxiety tests yielded abnormal findings sad group control group state anxiety inventory score respectively trait anxiety inventory score respectively depression test scores significantly higher sad sad groups control group respectively conclusionssuspected sad sad chronic tinnitus patients correlated thi anxiety depression understanding sad tinnitus patients may important manage patients effectively level evidence laryngoscope
since frequent communication applications takes place high speed networks deep packet inspection dpi plays important role network application awareness signature based network intrusion detection system nids contains dpi technique examines incoming packet payloads employing pattern matching algorithm dominates overall inspection performance existing studies focused implementing efficient pattern matching algorithms parallel programming software platforms advantages lower cost higher scalability either central processing unit cpu graphic processing unit gpu involved studies focused designing pattern matching algorithm based cooperation cpu gpu paper present enhanced design previous work length bounded hybrid cpu gpu pattern matching algorithm lhpma preliminary experiment performance comparison previous work displayed experimental results show lhpma achieve effective cpu gpu cooperation also higher throughput previous method
seasonal variations groundwater reveal lesser concentrations major ions except post monsoon seasons shallow aquifers compared deeper aquifers concentration deeper aquifers high seasons shows moderate positive relationship weathering depth compound lava flow groundwater mainly hco type shallow aquifers mixed type deeper aquifers fluoride shows positive correlation hco shallow aquifers inverse correlation hco deeper aquifers seasons approximately samples suitable drinking aquifers suitable irrigation purposes rock water interaction moderate alkalinity sluggish movement higher residence time main causes high deeper aquifers compared shallow aquifers recommendations drinking water requirement may met shallow aquifers surface water fluoride rich groundwater purposes effective defluoridation techniques like ion exchange reverse osmosis may adopted along integrated fluorosis mitigation measures rooftop rainwater harvesting supplementary calcium phosphorous rich food provided children creating awareness safe drinking water habits side effects high rich groundwater improving oral hygiene conditions measures
idiopathic pulmonary fibrosis ipf devastating progressive ultimately fatal lung disease combination poor prognosis uncertainty disease course severe symptom burden heavily impacts patients families quality life though new antifibrotic drugs shown decrease disease progression effect health related quality life hrqol convincingly demonstrated relentless disease ipf striving optimize hrqol complement endeavour prolong life unfortunately paucity interventions improving symptoms functionality patients ipf research focusing symptom improvement assessing optimizing hrqol limited review summarizes recent insights measuring improving quality life patients ipf discusses challenges management devastating disease moreover postulate new model continuous care ipf abcde ipf care assessing patients needs backing patients giving information support delivering comfort care focusing treating symptoms taking account comorbidities striving prolong life disease modification helping preparing patients caregivers eventual end life events likely occur
power domination number gamma graph minimum cardinality power dominating set paper initiate study power bondage number graph minimum cardinality among sets subset gamma gamma obtain sharp upper bound terms degree prove nonempty tree also provide conditions
stanford biodesign launched innovation fellowship first kind postgraduate training experience teaching biomedical technology innovators need driven process developing medical technologies delivering patients since many design oriented educational programs initiated yet impact type training remains poorly understood study measures career focus leadership trajectory productivity biodesign innovation fellowship alumni based survey data public career information also compares alumni certain publicly available metrics finalists interviewed selected overall alumni employed health technology contrast finalists interviewed selected leadership alumni hold managerial higher positions compared finalist group total alumni reported fellowship extremely beneficial careers measure technology translation patients reached technologies developed directly biodesign innovation fellowship another aided solutions initiated alumni training study suggests positive impact fellowship program career focus leadership productivity alumni
purposethe purposes study evaluate self care symptom burden reported infections among individuals lower extremity primary lymphedema examine differences self care symptom burden reported infections individuals unilateral bilateral lower extremity primary lymphedema examine associations among self care status symptom burden reported infections individuals lower extremity primary lymphedema designa secondary data analysis used data collected cross sectional survey study supported national lymphedema network march january surveys available online hard copy order increase accessibility methodsdescriptive statistics conducted associations variables assessed using mann whitney tests chi square tests independence multiple logistic regression used test associations controlling potentially confounding variables findingsa total participants reported lower extremity primary lymphedema majority participants female white united states approximately two thirds respondents conducted home daily lymphedema self care half respondents reported experiencing symptom burden reported least one episode infection compared individuals unilateral lower extremity primary lymphedema individuals bilateral lower extremity lymphedema likely conduct skin care use alternative medications frequently reported symptoms likely report least one episode infection respondents reported use compression garments also less likely self reported pain poor range motion numbness participants reported exercising also less likely self reported pain participants reported least one episode infection also reported experiencing symptoms conclusionsindividuals lower extremity primary lymphedema experienced substantial symptom burden infection episodes significant associations identified among self care symptom burden reported infections clinical relevancethe findings support need clinicians educate patients lower extremity primary lymphedema regarding importance self care symptom management infection control critically important clinicians evaluate symptom burden reduce infections individuals lower extremity primary lymphedema
background adiponectin leptin implicated initiation pathomechanism alzheimer disease serum concentrations adipokines extensively studied however little known receptors disease objective developed novel approach examine whether receptors adiponectin adipor leptin lepr contribute pathomechanism achieve investigated effect genetic environmental factors associated expression receptors method used cbl app swe presen mice strains exposed restraint stress daily different time periods measured mrna expression adipor adipor lepr level adipor adipor proteins hippocampal prefrontal cortical areas mouse results detected brain region specific transcriptomic changes adiponectin receptors induced app transgenes acute chronic caused significant elevations adipor mrna expression hippocampus mice prefrontal cortex mrna expression adipor followed biphasic course mice promote changes expression adipor mrna adipor protein levels adipor mrna animals however showed significant increase prefrontal cortex regarding adipor adipor mrna protein expression relevant changes could measured stress exposure brain areas furthermore stress exposed groups exhibited little change lepr mrna expression conclusion findings indicate carrying transgenes associated induces modification expression adiponectin receptors case normal genetic background receptors also appear sensitive environmental factors genetically determined model less response stress stimuli could observed results suggest modification adipokine receptors could also considered therapeutic approach
background accurate diagnosis critical therapeutic decisions prognostication interstitial lung diseases ild however surgical lung biopsies carry high complication rates fibred confocal fluorescence microscopy fcfm offers alternative visualize lung tissue vivo cellular level minimal adverse events wanted investigate diagnostic utility safety using fcfm patients ild methods patients suspected ild fcfm images obtained multiple bronchopulmonary segments using miniprobe inserted working channel flexible bronchoscope procedure performed moderate sedation outpatient setting morphometric measurements fibre pattern analyses related computed tomography findings patients final diagnoses based multi disciplinary consensus results one hundred eighty four segments imaged patients males median age years range years grouped chronic fibrosing interstitial pneumonia patients ilds six distinct fcfm patterns observed normal increased fibres densely packed fibres hypercellular thickened fibres others non specific pattern resembling densely packed fibres seen least one segment patients chronic fibrosing interstitial pneumonia ild association inflammatory patterns hypercellular pattern fcfm also found conclusions study shows potential fcfm classifying ild role diagnosis remains limited
purpose reviewmanagement polycythemia vera essential thrombocythemia requires understanding key concepts regarding diagnosis risk stratification management recent findingsessential thrombocythemia polycythemia vera among philadelphia chromosome negative myeloproliferative neoplasms characterized overproduction blood cells complications include thrombosis hemorrhage progression myelofibrosis acute myeloid leukemia aml management essential thrombocythemia polycythemia vera requires recognition risk factors thrombosis hemorrhage risk stratification allows clinician make treatment plan may include antiplatelet therapy aspirin alone combination therapeutic phlebotomy case polycythemia vera cytoreductive therapy high risk patients either essential thrombocythemia polycythemia vera hydroxyurea remains first line therapy high risk patients essential thrombocythemia polycythemia vera whereas second line options include anagrelide pegylated ifn jak inhibitor ruxolitinib current evaluation pegylated ifn global phase iii studies provide clarity potential long term benefit risks associated biologic patients essential thrombocythemia polycythemia vera novel therapeutics aimed prevention disease progression myelofibrosis aml focus current clinical trials summaryrisk stratification patients essential thrombocythemia polycythemia vera age history thrombosis provides basis risk adapted therapeutic intervention aggressive control modifiable cardiovascular risk factors use antiplatelet agents control hematocrit less polycythemia vera cytoreductive therapy high risk essential thrombocythemia polycythemia vera patients focus management exact role ifn remains undefined active investigation recent approval ruxolitinib provides patients polycythemia vera second line option
frequently occurring subcircuit consists loop resistor field effect transistor fet capacitor fet acts switch controlled gate terminal clock voltage may many identical circuits connected parallel driven different phase clock subcircuit may acting sample hold passive mixer bandpass filter bandpass impedance work present useful analysis leads simple signal flow graph sfg captures fet circuit action completely across wide range design parameters sfg dissects circuit three filtering functions ideal sampling greatly simplifies analysis frequency response noise input impedance conversion gain leads guidelines optimum design analysis extended multi path realizations common applications part paper focuses analyses single path fet circuit signal transfer characteristics part extends analyses multi path fet circuit configurations followed noise driving point impedance analyses
paper investigate magnetic tunneling junction mtj device stochastic quantizer thermal noise mtj one parameters determining output thermal noise causes random switching magnet successfully exploited implement high performance stochastic quantization analog input function relating mtj output state analog input defined mtj quantization function subsequently optimized signal noise ratio snr found maximize information throughput best output input correlation achieved input signal amplitude times standard deviation mtj quantization function also demonstrate mtj based quantizer offers highest performance information quantized normally distributed input signal simulations quantize images containing information light intensity pattern also confirmed highest information throughput optimum snr utilized
introduction compared general population veterans wars afghanistan iraq oef oif likely engage hazardous alcohol use meet criteria mental health disorders including posttraumatic stress disorder ptsd major depressive disorder less known distinct profiles alcohol use behavior relate mental health symptoms method current study examined extent indicators alcohol use drinks per week peak blood alcohol concentration alcohol related problems categorized different alcohol risk profiles utilizing person centered approach also examined mental health symptoms ptsd depression anxiety related symptoms associated alcohol risk profiles participants veterans reported consuming alcohol within past month results latent profile analysis indicated four class solution yielded best fitting model profiles named based respective levels patterns alcohol use mental health symptoms significantly different among four profiles profiles veterans endorsed alcohol related problems severe alcohol behavior steady drinkers functional impairment also reported comorbid clinical symptoms ptsd depression anxiety binge drinkers functional impairment mild alcohol behavior profiles reported lowest levels mental health symptoms discussion findings highlight unique relationship distinct alcohol risk profiles mental health outcomes targeted interventions treatment options based unique alcohol risk profiles may helpful tailoring prevention intervention efforts detecting occurring mental health symptoms among oef oif veterans elsevier ltd rights reserved
high work stress consistently associated disturbed autonomic balance specifically lowered vagal cardiac control increased sympathetic activity may lead increased cardiovascular risk stress management procedures proposed reduce autonomic dysfunctions related work stress different categories workers exposed heightened work demands limited number studies addressed issue managers present study aimed evaluating effectiveness respiratory sinus arrhythmia rsa biofeedback intervention psychological physiological outcomes managers high level work responsibilities thirty one managers leading outstanding private public companies randomly assigned either rsa training rsa control group rsa training consisted five weekly min sessions designed increase rsa whereas controls provide daily stress diary week training managers groups reported reduced heart rate rest lower anxiety levels improvement health related quality life importantly managers rsa group showed increased vagal control indexed increased rsa decreased sympathetic arousal indexed reduced skin conductance systolic blood pressure lower emotional interferences compared managers control group results study showed rsa training effective improving cardiac autonomic balance rest moreover findings study underline effectiveness biofeedback reducing psychophysiological negative outcomes associated stress managers
internet things becoming important field research gaining public attention along availability internet main aspect paper develop system providing remote access home appliances security mishaps user home proposed system cheaper effective provides aspects user expensive well known companies system embedded cloud database linked backend android application communicates database packet sent microcontroller perform desired action benefit implementing cloud servers accessibility existing networks means user control house office anywhere world active feedback database provides periodic information user cost time long device switching existing system cloud enables easy access home automation user providing easy use online services runs backend android phone open standardized protocols protected password home automated devices increase convenience offering choice freedom users
paper introduces preliminary developments nsf funded going educational project project goal enhance student technical professional skills business knowledge integrating lean manufacturing education traditional manufacturing engineering program group faculty members complementary background expertise engineering business taught new lean course attracted student enrollments five departments across campus addition plant tours guest lectures real world industrial projects particularly designed innovative unique experience lean lego simulation lls proven valuable students better understand lean principles applications course survey shows student feedback overwhelmingly positive evaluation also carried measure well project working viewpoint participants especially faculty collaboration student achievements
teaching evaluation computer programming difficult checking lab topics making recommendations students time consuming activity therefore teacher use tools automatically check solutions problems exercises proposed article designed mooc massive open online course type application integrated lms learning management system moodle learning environment provides user interface student interacts proposing solutions proposed problems meanwhile evaluating results recent years learning applications developed lot support platforms learning evolved proposing new approaches range technical solutions solutions transformed learning evaluation efficient activity due immediately feed back offered students many universities using mooc platforms approaching increasingly courses students article present model application adapted introductory teaching course called computer programming students technical faculties
article describes creative design activity introduce engineering students mechatronic prototyping goal find creative task increase student confidence skills mechanical design electrical circuits microcontrollers programming present paper robot exercise design activity blends everyday materials cardboard electronic components activity introduced academic year repeated every year since global industry sponsored design course stanford university paper robot exercise resulted observation students intimidated create functional prototypes microcontrollers teaching team needed way quickly introduce tools programming electronic components encourage creative experimentation early course results include task performance rate students successfully made robot meeting minimum requirements students reported increase knowledge programming microcontrollers arduino increased knowledge creating electronic circuits raw components activity may modified introduce younger students mechatronic platforms stem education curriculum
triterpenic acids widely distributed many fruits known medicinal benefits study bioavailability important task better understanding triterpenic acids although many methods based fluorescence labeling triterpenic acid determination established reported methods needed anhydrous conditions suitable convenient study triterpenic acid bioavailability inspired versatile method overcomes difficulty reported methods first developed study novel method using benzo acridin acetohydrazide baah fluorescence labeling reagent coupled high performance liquid chromatography fluorescence detection first developed study triterpenic acid bioavailability furthermore labeling conditions optimized order achieve best fluorescence labeling yield optimal conditions quantitative linear range analytes ngml correlation coefficients detection limits triterpenic acid derivatives achieved within range ngml proposed method successfully applied study triterpenic acid bioavailability excellent applicability good reproducibility
radio devices complexes strategic application highly complicated technical systems working difficult conditions including conditions intentional interference radio systems developed various times various technical parameters operation requirements makes common use even difficult due mutual influence article examines semi markov model maintaining electromagnetic stability system control radio complexes suggest analytical tools solving problem maintaining electromagnetic compatibility total radio complexes basis analysis state model conditions interference use state space representation relativity theory thus suggested tools allow calculate efficiency radio systems operation probability task performance period exceeding predetermined one work offers methods studying dependence efficiency parameter following parameters system functioning expected value time radio system operation task performance expected value start interference expected value restoring operation capacity probability fulfillment conditions overlapping frequencies interference power exceeding limit value signal power resulting mathematical tools allow calculate average time effective radio system functioning conditions unintentional intentional interference calculate probability effective simultaneous work two radio systems unintentional mutual interference also help determine optimum plan frequency resource interference reduction developed methods determining optimum working plan number heterogeneous radio complexes thus aiming build single effective system control changing dynamically parameters radio emissions
background left ventricular systolic dysfunction moderate aortic stenosis frequent advancing age often coexist afterload reduction mainstay pharmacological treatment heart failure aortic valve replacement avr formally indicated symptomatic severe objectives study sought determine clinical outcome patients concomitant moderate systolic dysfunction methods echocardiographic clinical data patients moderate systolic dysfunction large academic institutions retrospectively analyzed moderate defined aortic valve area systolic dysfunction defined ejection fraction primary endpoint composite cause death avr hospitalization results total patients mean age years male included majority symptomatic time index echocardiogram new york heart association nyha functional class nyha functional class iii nyha functional class ischemic heart disease present patients year follow primary composite endpoint occurred main predictors primary endpoint male sex nyha functional class iii peak aortic jet velocity rate composite cause death hospitalization rate cause death rate hospitalization avr occurred patients conclusions patients concomitant moderate systolic dysfunction high risk clinical events studies needed determine earlier avr patients might improve clinical outcome american college cardiology foundation
paper presents novel approach estimating ego motion vehicle dynamic unknown environments using tightly coupled inertial visual sensors improve accuracy robustness exploit combination point line features aid navigation mathematical framework based trifocal geometry among image triplets simple unified point line features fusion algorithm design employ extended kalman filter ekf error state prediction covariance propagation sigma point kalman filter spkf robust measurement updating presence high nonlinearities outdoor indoor experiments show combination point line features improves estimation accuracy robustness compared algorithm using point features alone
present work cellulose pulp obtained paper industry dissolved peg naoh system resulting solution polymerized presence monomer sodium acrylate crosslinker methylene bisacrylamide via free radical polymerization gels loaded anti diabetic drug metformin hydrochloride met detailed investigation release drug studied various kinetic models applied release data finally vivo study carried albino wistar rats see efficacy hydrogel systems lowering glucose level
positive stranded rna viruses hepatitis virus hcv assemble viral replication complexes remodeling host intracellular membranes membranous web precise composition replication complexes detailed mechanisms formed incompletely understood show human immunity related gtpase irgm known contribute autophagy plays previously unrecognized role process show irgm localized golgi apparatus regulates fragmentation golgi membranes response hcv infection leading colocalization golgi vesicles replicating hcv results show irgm controls phosphorylation gbf guanine nucleotide exchange factor arf gtpases normally operates golgi membrane dynamics vesicle coating resting cells also find hcv triggers irgm mediated phosphorylation early autophagy initiator ulk thereby providing mechanistic insight role irgm hcv mediated autophagy collectively results identify irgm key golgi situated regulator links intracellular membrane remodeling autophagy golgi fragmentation viral replication
goal paper describe added value complexities nonlinear system identification applied large scale industrial test setup additional important insights provided frequency domain nonlinear approach significant systems nonlinear system identification important example estimate noise non linearities levels indicate mechanical configuration issues goal provide final full scale model explore applicability nonlinear system identification theories complex multi physical non academic test case elsevier ltd rights reserved
system identification approach incorporated groundwater time series analysis revealing information concerning local hydrogeological situation aim work analyse water table fluctuations outcrop area guarani aquifer system gas brotas brazil using data groundwater monitoring network water table dynamic modelled using continuous time series models reference hydrogeological system upon operate model climatological inputs precipitation evapotranspiration generate impulse response functions parameters related physical conditions concerning hydrological processes involved interpretation model parameters two sets monitoring wells selected different land use sites presented exemplifying effect different water table depths distance nearest drainage location systematic trends water table depths also identified model parameters specific periods related plant development crop harvest land use changes
new innovations novel approaches peripheral arterial occlusive disease brought enormous benefits vascular patient diseases manageable surgical intervention easily successfully treated minimally invasive procedures early days percutaneous intervention filled inventions new devices today focus centers using modern technology manufacturing improve upon devices advances guidewires catheters allowed visualize treat lesions nearly vessel technology guiding towards specialized applications specific lesions specific vessels however one big hurdles remaining treating arterial occlusive diseases rate restenosis need reinterventions location architecture vessels make uniquely difficult treat call new technology address challenges current developments drug eluting bioabsorbable stents forefront new advancements specifically directed improving current patency restenosis rates perhaps next step percutaneous intervention rely nanotechnology molecular surface engineering may achieve new era devices able target specific cell ligands proteins prevent inflammatory proliferative response vessels present review focus current literature regarding technological devices peripheral percutaneous interventions clinical applications future advancements materials engineering biotechnology continue improve current standard percutaneous intervention peripheral arterial occlusive diseases
paper series offshore wind farm onshore modular multilevel converter mmc presented consideration different cable models normally cable represented either small capacitance sections implies frequency dependent effects hvdc cable neglected one careful using cable models high frequency simulations especially series offshore wind farm whose topology forms resonance circuit consequently accurate model cable adopted represent transient characteristic hvdc transmission system proper way paper shows two common lumped parameter types cable model small capacitance section model unable provide equivalent damping effect wideband cable model universal line model ulm wideband model suitable electromagnet transients emt analysis distributed parameters make impossible transferred state space representation paper first introduces topology series offshore wind farm resonance characteristic wind farm topology analysed based different cable models finally offshore wind farm simulated three types cable models controlled modular multilevel converter mmc
variability solar irradiance level ambient temperature photovoltaic systems necessitates use maximum power point tracking mppt systems ensure continuous harvesting maximum power paper presents sensorless current mppt algorithm using model predictive control mpc main contribution paper use model based predictive control principle eliminate current sensor usually required well known mppt techniques perturb observe predicting system states horizon time proposed method becomes elegant embedded controller allows faster response lower power ripple steady state conventional technique rapidly changing atmospheric conditions becomes possible without requiring expensive sensing communications equipment networks direct measurement solar irradiation changes performance proposed mpc mppt reduced load sensitivity evaluated basis industrial european efficiency test assesses performance systems dynamic environmental conditions proposed control technique implemented experimentally using dspace platform verify simulation results
feature representation classic problem machine learning community due fact different representations entangle hide less different explanatory factors variation behind raw data especially scene classification performance generally depends discriminative power feature representation recently unsupervised feature learning attracts tremendous attention ability learn feature representation automatically however reliable performance feature representations unsupervised learning always requires large number features complex framework mid level feature representation alleviate drawbacks paper presents new framework mid level feature representation need learnmany convolutional features unsupervised feature learning process parameter settings detail unsupervised feature learning method sparse autoencoder employed learn relatively small number convolutional features input dataset extended features extracted learned features multiple normalized difference features extraction method compose derivative feature set mid level feature representation stage order avoid poor performance standard pooling technology solving problems brought rotation translation scene images global feature descriptors histogram moments mean variance standard deviation utilized build mid level feature representations images validation comparison purposes proposed approach evaluated via experiments two challenging high resolution remote sensing datasets results demonstrate approach effective shows strong performance remotely sensed scene classification
evaluated influence baseline age bone mineral density bmd serum levels vitamin response risedronate treatment risedronate consistently increased bmd results suggest vitamin supplementation may necessary achieve optimal treatment effect furthermore early intervention may help prevent bone fractures aimed investigate influence baseline age bmd vitamin insufficiency response risedronate treatment data regarding patients obtained registries three phase iii clinical trials risedronate response treatment expressed terms bmd increase occurrence new vertebral fractures patients stratified baseline values age years lumbar spine bmd score osteoporotic non osteoporotic serum levels hydroxyvitamin deficient non deficient risedronate consistently increased lumbar spine bmd groups similar percentage absolute increments age tertiles percentage absolute increment bmd significantly higher osteoporotic non osteoporotic patients baseline patients whose baseline serum levels hydroxyvitamin available vitamin deficiency insufficiency percentage absolute increments bmd lower respectively vitamin deficient non deficient patients new vertebral fractures occurred osteoporotic non osteoporotic patients respectively end treatment therapeutic response elderly patients consistent early initiation risedronate treatment may help prevent fractures risedronate induced increase bmd lower patients vitamin deficiency suggesting vitamin supplementation important achieve optimal treatment response
study investigates land cover change near abandoned pine point mine canada northwest territories industrial mineral development transforms local environments effects disturbances often long lasting particularly subarctic boreal environments vegetation conversion take decades located boreal plains ecozone pine point mine extensive open pit operation underwent little reclamation shut apply remote sensing landscape ecology methods quantify land cover change years following mine closure using time series near anniversary landsat images performed supervised classification differentiate seven land cover classes used raster algebra landscape metrics track changes land cover composition configuration years since mine shut compared results site wood buffalo national park never subjected extensive anthropogenic disturbance space time substitution provided analog ecosystem pine point region might developed absence industrial mineral development found dense conifer class dominant park exhibited larger contiguous patches mine site bare land mine site showed little conversion time combination raster algebra landscape metrics allowed track broad changes land cover composition configuration improved access affordable high resolution imagery necessary effectively monitor land cover dynamics abandoned mines
identification potential sites rainwater harvesting rwh important step toward maximizing water availability land productivity arid semi arid regions characterised water scarce country egypt limited fresh water supplies expected suffer water stress year therefore important develop means available supply water maintain human habitability sustainable manner practiced simply indispensable many countries around world rainwater harvesting rwh promotes sustainable efficient manner exploiting water resources present study suitable areas sustainable stormwater harvesting storage egypt identified using remote sensing land cover data location assessment linked decision support system dss dss took consideration combination thematic layers rainfall surplus slope potential runoff coefficient prc land cover use soil texture taking account five thematic layers spatial extents rwh suitability areas identified analytical hierarchy process ahp model generated rwh map five categories suitability excellent good moderate poor unsuitable spatial distribution categories area investigated study area classified excellent good terms rwh respectively area classified moderate unsuitable poor respectively areas excellent good suitability slopes intensively cultivated areas major soil type excellent suitability areas loam rainfall ranged use number rwh sites excellent areas recommended ensure successful implementation rwh systems
solar reactors designed constructed thermochemical applications present different configurations general performance selection solar reactor optimizes particular process always difficult challenge work studies two types reactor configuration means comparative experimental analysis employed solar device able operate fixed reactor packed bed samples rotary kiln reduction cuo cuo tested operation modes due proved potential interest thermochemical storage material found heat transfer hindered static experiments limiting fraction reactive sample thermal gradients degrees found packed bed thermocouple camera measurement heating rates total fed energy must restricted risk front sample melt resulting several operation drawbacks contrast mixing conditions rotary kilns allowed higher heating rates led homogenous sample temperature maximum reaction yields stationary mode overpass achieved rotary mode temperatures degrees thermal efficiencies limited operation modes due high thermal inertia solar reactor rotary mode admitted much energy thermal efficiency even lower static solution increase rotary kilns thermal efficiency working continuous mode elsevier ltd rights reserved
background animal human studies indicate gabbr encoding gabab receptor subunit slca encoding neuronal gamma aminobutyric acid gaba transporter gat play role addiction modulating synaptic gaba therefore variants genes might predict risk resilience alcoholism methods study included populations differed ethnicity alcoholism phenotype african american men treatment seeking inpatients single comorbid diagnoses alcohol drug dependence controls finnish caucasian men incarcerated alcoholics half comorbid antisocial personality disorder controls community sample plains indian men women alcoholics controls seven gabbr tag single nucleotide polymorphisms genotyped finnish samples genotyped replication also uniquely african functional slca insertion promoter polymorphism ind genotyped aas results found significant congruent association gabbr alcoholism populations major genotype heterozygotes aas finns major allele pis significantly common alcoholics moreover slca ind abundant controls major genotype predicted alcoholism analysis combined gabbr slca ind genotypes showed heterozygotes irrespective ind status increased risk alcoholism whereas carriers ind allele either homozygote resilient conclusions results show gabbr slca minor genotypes alleles protective risk alcoholism finally gabbr might predict treatment response adverse effects baclofen gabab receptor agonist
real world many phenomena time related last three decades database community devoted much work dealing time facts databases many approaches incorporating time relational model already devised assume exact time facts known however assumption hold many practical domains temporal indeterminacy facts occurs treatment valid time indeterminacy requires depth extensions current relational approaches paper propose theoretically grounded approach cope issue overcoming limitations related approaches literature particular present temporal relational model propose new temporal relational algebra query also formally study properties new data model algebra thus granting approach interoperable pre existent temporal non temporal relational approaches implementable top finally consider computational complexity showing limited overhead added moving determinate indeterminate time
telocytes tcs represent new distinct type interstitial cells found many organs including lungs tcs mainly defined small cellular body arise long hundreds micrometers extensions named telopodes last years tcs characterized respect microrna profiles gene features proteome signatures also ultrastructural configuration elucidated aid fib sem technology tcs able communicate homo heterocellular contacts neighboring cells also able transfer genetic information signaling molecules influence cells means extracellular vesicle release however exact function lung tcs remains unclear review potential significance tcs pathogenesis pulmonary diseases also discuss future possibilities targeting tcs potential therapeutic strategy
objective examine sociodemographic factors associated high parental self efficacy perceived control determine self efficacy control relate home learning environment hle including whether mediate relationship sociodemographic characteristics hle among low income parents young children methods cross sectional survey english spanish speaking parents years age older children months old assess parental self efficacy perceived control hle sociodemographic characteristics bivariate analysis identified sociodemographic predictors high self efficacy control separate multivariate linear regression models used examine associations self efficacy control hle formal path analysis used assess whether self efficacy control mediate relationship sociodemographic characteristics hle results participants white immigrants completed survey spanish born subjects completed english surveys higher educational levels significantly higher mean self efficacy perceived control scores higher self efficacy perceived control associated positive change hle score separate multivariate models self efficacy beta confidence interval control beta self efficacy acted mediator low self efficacy explained part association parental depressive symptoms immigrant status less optimal hle respectively conclusions high parental self efficacy perceived control positively influence hles young children self efficacy alone mediates relationship parental depressive symptoms immigrant status less optimal early home learning
review prepared american society mechanical engineers lissner medal specifically discusses research performed orthopaedic biomechanics laboratories pediatric cranial bone mechanics patterns fracture collaboration forensic anthropology laboratory michigan state university cranial fractures often important element seen forensic anthropologists investigation pediatric trauma cases litigated courts forensic anthropologists forensic biomechanists often called testify cases little basic science developed support testimony following review studies conducted laboratories supported national institute justice begin understanding mechanics patterns pediatric cranial bone fracture lack human pediatric specimens studies utilize immature porcine model much case evidence involves cranial bone fracture studies described focus determining input loading based resultant bone fracture pattern studies involve impact parietal bone often fractured cranial bone begin experiments entrapped heads progressing involving free falling heads studies involve head drops onto different types shapes interfaces variations impact energy studies show linear fractures initiating sutural boundaries away impact site flat surface impacts contrast depressed fractures focal impacts results incorporated fracture printing interface fpi using machine learning pattern recognition algorithms interface used help interpret mechanisms injury pediatric death cases collected medical examiner offices ultimate aim program study develop human fracture printing interface used forensic investigators determining mechanisms pediatric cranial bone fracture
computer graphics combination mobile devices finds many applications fields entertainment education displaying data amount information shown user real time depends mostly speed visualisation process thus optimization graphic chain application development development optimized solution developers need familiar possibilities differences developing platform appropriate way implementation graphics engine sample scenes show basic indicators quality level current smart devices paper focuses problem selecting proper graphics engine selected visualization task well optimization several used techniques visualisation different types effects quality implementation finally evaluated developed testing engine provides relevant data sense frame per second fps based visualisation speed second aspect quality evaluated visual correctness four selected scenes water level volumetric light scattering fur simulation forest
software development life cycle structured process including definition user requirements specification system design programming design task comprises transfer natural language specifications models class diagram unified modeling language considered one useful diagrams formal description user requirements serves inputs developers automated extraction uml class diagram natural language requirements highly challenging task paper explains vision automated tool class diagram generation user requirements expressed natural language new approach amalgamates statistical pattern recognition properties natural language processing techniques patterns defined extraction class diagram concepts concepts captured xml metadata interchange file generated imported computer aided software engineering tool build corresponding uml class diagram copyright john wiley sons ltd
antifat attitudes refer stereotyping based people weight potential explanation strong negative attitudes toward obese individuals relates people emotional reactions study conducted female students suggested physical disgust germ aversion perceived controllability weight play central role explaining individual differences exist antifat attitudes results showed positive relationship physical disgust germ aversion additionally found positive correlation physical disgust perceived controllability weight furthermore positive relationship antifat attitudes physical disgust germ aversion found finally perceived controllability weight positively related antifat attitudes path analysis conducted showed mediational effect perceived controllability weight relationship physical disgust antifat attitudes finally discussed results frame antifat attitudes literature
quantum correlations qcs separable states proposed key resource certain quantum communication tasks quantum computational models without entanglement paper family nine parameter separable states obtained arbitrary mixture two sets qubit product pure states considered qcs separable states studied analytically numerically using four quantifiers measurement induced disturbance luo phys rev ameliorated mid girolami phys math theor quantum dissonance modi phys rev lett new quantum dissonance rulli phys rev respectively first inherent symmetry concerned separable states revealed nine parameter separable states concerned paper transformed three parameter kernel state via certain local unitary operation four different expressions concretely derived four quantifiers furthermore comparative studies qcs presented discussed analyzed distinct features exposed find framework four quantifiers mixed original two pure product states bigger qcs separable states results reveal intrinsic features qcs separable systems quantum information
bactericidal permeability increasing protein bpi gene polymorphisms extensively investigated terms associations inflammatory bowel disease ibd contradictory results aim meta analysis evaluate associations bpi gene polymorphisms risk ibd crohn disease ulcerative colitis eligible studies pubmed embase cochrane library databases identified ten studies five five published five papers included meta analysis polymorphism associated decreased risk allele model dominant model homozygous model data suggested bpi polymorphism associated decreased risk bpi polymorphism associated risk
three phase induction motors play key role electromotive force production although widespread use industrial applications leads variety defects impair normal operation paper proposes alternative method based artificial neural networks classifying detecting bearing faults three phase induction motors connected directly power grid experimental tests conducted laboratory consider practical conditions voltage unbalances differing load torques analyses performed time domain based electric motor quantities voltages currents acquired considering half cycle voltage grid performance efficacy proposed fault detection method evaluated validated using personal computer conduct online experimental tests embedding digital signal processors proposed method also tested electrical machines used sugar cane industry
background literature provides several studies effects cocaine exposed fetus however majority data comes animal models objective objective study present socio demographic clinical data crack cocaine using pregnant women babies compared non users methods cross sectional study comprised dyads crack cocaine using mothers babies control dyads addition socio demographic data babies information data collection based abipemi socioeconomic level wais mini psychopathology assist drug use results crack users comparison non users partner presented lower prevalence antisocial personality disorder suicide risk users higher non users none users participate prenatal care babies crack cocaine using mothers gave birth weighed significantly less controls discussion users higher degree psychopathology lower attendance prenatal care overlap adverse factors exposed mothers babies sum vulnerabilities could result significant harm developing infant
introduction comprehensively described expression profiles mitochondrial dna nuclear dna genes encode subunits respiratory oxidative phosphorylation oxphos complexes hippocampus young controls age matched mild cognitively impaired mci alzheimer disease subjects methods hippocampal tissues non controls amnestic mci cases analyzed affymetrix plus arrays results microarray data revealed significant regulation oxphos genes particularly encoded nucleus contrast regulation gene mci subjects compared cases significant differences observed mtdna genes identified array mci subjects except one discussion findings suggest restoration expression nuclear encoded oxphos genes aging could viable strategy blunting progression published elsevier inc behalf alzheimer association
computer aided design cad models thin walled parts sheet metal plastic parts often represented corresponding midsurfaces computer aided engineering cae analysis reason surface elements shell elements need placed midsurface provide fairly accurate results requiring far lesser computational resources time compared analysis using solid elements existing approachesof midsurface computation reliable robust result ill connected midsurfaces missing patches gaps overlaps etc errors need corrected mostly manual time consuming process requiring hours even days thus automatic robust technique computation well connected midsurface need hour paper proposes approachwhich instead working complex final solid shape typically represented rep boundary representation leverages feature information available modern cad models techniques defeaturing generalization decomposition first model defeaturedby removing irrelevant features generating simplified shape called gross shape remaining features generalizedto corresponding generic loft feature equivalents model decomposed sub volumes called cells respective owner loft features graph populated cells graph nodes nodes classified midsurface patch generating nodes called solid cells scells interaction resolving nodes called interface cells icells using owner loft feature parameters scells compute midsurface patches using generic logic patches get connected appropriately icells resulting well connected midsurface efficacy approach demonstrated computing well connected midsurfaces various real life sheet metal parts
current mechanical methods oil extraction based electric motor drive systems existing schemes oilfield power supply electrical system operating modes actualize development implementation energy conservation measures high potential lying raising energy efficiency oilfield equipment current state power supply network new oil wells increasing power consumption associated growth crude oil production require new technical organizational measures ensuring reliability power supply reduction energy losses maintenance desired voltage level operating equipment paper presents example technical solution justification implementation aimed reducing energy losses oilfield electrical power network reactive power compensation devices filter compensating devices gradually put operation within existing power schemes enabled increase flow capacity power transmission line order commission new oil well authors analyzed operating modes electrical system used two oil fields showed potential introducing effective energy conservation measures
background thyroid hormone inactivating enzyme type deiodinase induced hypertrophic ischemic cardiomyopathy leading state local cardiac hypothyroidism whether induction occurs dilated cardiomyopathy unknown methods study characterized changes cardiac thyroid hormone signaling transgenic model progressive dilated cardiomyopathy mice results cardiac dramatically induced fold progression dilated cardiomyopathy mice induction localized cardiomyocytes associated decrease myocardial thyroid hormone signaling conclusions cardiac induced mouse model dilated cardiomyopathy indicating induction may general response diverse forms cardiomyopathy
study made characteristics older adults showing interest participating health education course given peers determining degree interest health education important assessing impact target population evaluating dissemination strategy course successful aging groups alder adults came together discuss health related issues course given senior health educators aged years peer group determine interest course answer cards sent letter invitation independently living inhabitants aged dutch community rate expressed interest course interest highest among females age group unmarried low wellbeing males age group females aged lower socio economic status inactive comparatively less interested subscription course distinguished mere interest course expressed interest people low socio economic status reduced level wellbeing many physical limitations poor self efficacy actually subscribed concluded health education program continued special attention paid groups showed lower levels uptake involving intermediates groups course development recommended elsevier science ireland ltd
purpose previous research indicates mentalisation based treatment mbt effective therapeutic programme difficulties associated borderline personality disorder bpd purpose paper explore service user experiences therapy design methodology approach seven adults five female two male recruited via three nhs trusts interviewed participants attending intensive patient mbt bpd months data analysed using interpretative phenomenological analysis findings participants experienced group component mbt challenging unpredictable highlighted developing trust key benefitting mbt much difficult achieve group sessions individual therapy particularly attending mbt less five six months structure mbt generally worked well participants identified individual therapy core component achieving change participants learned view world positively due mbt practical implications enhanced mentalisation capacity may help address specific challenges associated bpd namely impulsivity interpersonal difficulties mbt therapists confronted ongoing task creating balance sufficient safety adequate challenge mbt potential benefits drawbacks differing structural arrangements mbt programmes within considered originality value learning service user perspectives facilitated enhanced understanding experiences change mbt addition specific factors may impact mentalisation capacity throughout programme factors addition implications mbt suggestions future research discussed
speakers respond automatically rapidly compensate brief perturbations pitch auditory feedback specific adjustments vocal output require integration brain regions involved speech motor control order detect sensory feedback error implement motor correction cortical regions involved pitch reflex phenomenon highly vulnerable targets network disruption alzheimer disease examined pitch reflex patients compared age matched control group measured degree behavioral compensation peak compensation extent adaptive response pitch response persistence healthy controls reached peak compensation cents demonstrated sustained compensation cents patients contrast demonstrated significantly elevated peak compensation cents reduced sustained response pitch response persistence cents degree increased peak compensation predicted executive dysfunction degree impaired pitch response persistence predicted memory dysfunction patients current study demonstrates pitch reflex sensitive behavioral index impaired prefrontal modulation sensorimotor integration compromised plasticity mechanisms memory elsevier inc rights reserved
power thought increase discrimination toward subordinate groups yet effect different forms implicit bias remains unclear tested whether power enhances implicit racial stereotyping addition implicit prejudice evaluative associations examined effect power automatic processing faces implicit tasks study showed manipulated high power increased forms implicit bias relative low power using neural index visual face processing component erp study revealed power affected encoding white ingroup black outgroup faces whereas high power increased relative processing outgroup faces evaluative judgments prejudice task decreased relative processing outgroup faces stereotype trait judgments indirect effect power implicit prejudice enhanced processing outgroup versus ingroup faces suggested potential link face processing implicit bias together findings demonstrate power affect implicit prejudice stereotyping well early processing racial ingroup outgroup faces
reviewed cases patients diagnosed necrotizing otitis externa tertiary university affiliated medical center mean overall hospitalization duration days patients showed specific seasonal incidence mean duration symptoms prior hospitalization weeks duration correlated outcome patients presented cranial neuropathies however presentation correlated adverse outcome pseudomonas aeruginosa main causative organism multidrug resistance rate high rate fungal pathogens noted seventeen patients eventually operated however patients needed extensive surgery general anesthesia computed tomography evidence adjacent structures involvement correlated adverse outcome eighty percent patients improved clinically overall death rate disease related mortality rate findings state importance limited surgical intervention microbiologic cultures disease treatment particularly important patients cranial neuropathies finding adjacent structural involvement correlate adverse prognosis rising pseudomonal antibiotic resistance fungal infections may challenge antibiotic treatment future elsevier inc rights reserved
interleukin cytokines predominantly expressed epithelial cells significant upregulation epidermal recognised characteristic psoriatic skin inflammation known induce inflammatory responses dendritic cells fibroblasts epithelial cells although vascular alterations hallmark psoriatic lesions dermal endothelial cells well known play critical role skin inflammation effects endothelial cells unexplored show endothelial cells including dermal microvascular cells express functionally active receptor adhesion molecules vcam icam upregulated stimulation reversed presence endogenous receptor antagonist stimulated endothelial cells secrete proinflammatory chemokines ccl ccl chemotaxis assays showed increased migration cells following stimulation endothelial cells results suggest role dermal vascular compartment likely enhance psoriatic skin inflammation activating endothelial cells promoting leucocyte recruitment
new oral anticoagulants noacs shown comparable warfarin patients non valvular atrial fibrillation meta analysis performed evaluate efficacy safety noacs perioperative anticoagulation catheter ablation pubmed embase cochrane library cnki vip sinomed searched articles published august data calculated revman using fixed effects model nineteen studies total patients included meta analysis noac treatment associated fewer overall bleeding events continuous warfarin treatment similarly fewer overall bleeding events noac treatment interrupted warfarin treatment subgroup analyses incidence overall bleeding events minor bleeding events interrupted noac group lower continuous warfarin group noac treatment increase risk thromboembolic complications compared warfarin treatment findings meta analysis suggested periprocedural noac therapy effective continuous warfarin therapy preventing thromboembolism lower incidence bleeding complications interrupted noac therapy periprocedural period might result lower incidence bleeding complications compared continuous noac therapy
paper describes novel method design simple real time gps global positioning system receiver system navigation positioning tracking applications system developed provide various positioning navigational parameters like latitude longitude velocity altitude name current location etc system also provides information regarding satellites view terms number satellites tracked satellite prn pseudo random noise number parameters like snr signal noise ratio satellite signal azimuth elevation information displayed graphical user interface gui system also provides website application values parameters gui displayed tabulated form website parameter values continuously updated displayed gui updated parameter values gui also added table website hence table shows real time parameter values along values previously displayed gui internet based sms short message service application also developed message real time latitude longitude altitude speed location name user mobile system consists antenna acquires satellite signals presented gps receiver system uses hardware gps receiver provided usb universal serial bus connector receiver compatible easily connected personal computer laptop antenna connected gps receiver acquire signals satellites line sight antenna satellite software used system developed net visual basic net programming language net application oriented computer programming language easy program understand main feature system ease use system visual display results seen laptop
studies shown hepatic insulin resistance disorder glucose lipid metabolism plays vital role type diabetes clarify function dapper glucose lipid metabolism liver investigated relationships dapper adenosine triphosphate atp mediated activation pik alct observed reduction hepatic dapper mice homozygous spontaneous diabetes mutation hfd induced diabetic mice hepatic overexpression dapper improved hyperglycemia insulin resistance fatty liver also increased akt pakt signaling repressed gluconeogenesis lipogenesis conversely shdapper induced knockdown hepatic dapper promoted gluconeogenesis lipogenesis furthermore dapper activated pik alpha akt insulin independent manner inducing atp production secretion vitro blockade atp receptors downstream phospholipase plc inositol triphosphate receptor ipr reduced dapper induced increase cytosolic free calcium dapper mediated pik akt activation removal calcium medium conclusion dapperl attenuates hepatic gluconeogenesis lipogenesis elsevier rights reserved
remote sensing shown immense capability large scale estimation air temperature air one important environmental state variables using land surface temperature lst data following recent investigations air lst relationship article propose advanced statistical approach realm tested approach estimation air eastern part iran using modis daytime nighttime lst products auxiliary variables including julian day solar zenith angle extraterrestrial solar radiation latitude altitude reflectance various visible infrared bands vegetation indices fourteen statistical models constructed stepwise regression analysis evaluated along year period using modis meteorological station data results study indicated statistical approach performed reasonably well final proposed model could estimate average air validation mean absolute error degrees daily weekly scales respectively nighttime lst julian day altitude solar zenith angle indicated effective variables capturing variations air study region variables influenced land surface land cover properties including reflectance different bands vegetation indices showed negligible effect air lst relationship within study area indicated proposed models generally performed better lower altitude regions
diagnosis migraine children generally straightforward treatment seem complex number medication choices many used label patients intermittent migraines often managed ibuprofen naproxen taken needed unfortunately time children present practice often tried medications without improvement triptans frequently prescribed patients good success important make patient aware possible associated serotonergic reactions patient one headache per week headaches prolonged prophylactic treatment indicated practice overwhelming majority patients treated amitriptyline topiramate generally allow side effect tolerability guide choice medication cyproheptadine often used younger patients comes liquid form evidence supporting use propranolol though potential worsening underlying asthma symptoms may limit use sodium valproate must used caution female patients childbearing age due significant teratogenicity risks prophylactic treatments less robust evidence include antiepileptic drugs gabapentin zonisamide levetiracetam calcium channel blockers verapamil amlodipine angiotensin receptor blocking agent candasartin available usa almost patients practice advised take magnesium supplementation magnesium supplement relatively adverse effects good evidence improvement migraine symptoms evaluate lifestyle issues comorbidities patients ignoring make successful treatment near impossible good sleep adequate hydration appropriate diet exercise vitally important finally patients benefit psychology evaluation cognitive behavioral therapy stress management biofeedback tremendously helpful improving quality life migraineurs
applications incorporating variable speed drives vsd may experience torsional vibration problems vibration phenomenon typically appear two reasons excitation torsional resonance pulsating torque ripple closed loop electro mechanical interaction vsd driven load paper aims explain mechanism torsional vibration vsd proposes approach model complete drive system order predict torsional vibration optimize control system prior commissioning method easy apply much less time consuming compared time domain simulations theoretical results verified real example compressor drive
background limited data regarding associated factors return sports activities years anterior cruciate ligament acl reconstruction purpose test interrelationships patient characteristics concomitant articular lesions graft laxity maintenance sports activities years acl reconstruction hypothesized years operation young adult men maintenance greater activity level better knee function would associated greater preinjury activity level younger age reconstruction absence concomitant articular lesions minimal graft laxity follow study design case series level evidence methods one hundred six men autologous hamstring acl reconstruction ages years reviewed years surgery excluded patients contralateral acl tear revision reconstruction another injury impairing function fifty five patients eligible available follow independent variables included preinjury tegner score time interval injury surgery smoking status age articular lesions side side difference pivot shift grade main outcome measures tegner activity level international knee documentation committee ikdc subjective score knee injury osteoarthritis outcome scale koos score years surgery results greater tegner activity level follow associated regression model greater preinjury tegner activity level correlation coefficient lower difference correlation coefficient negative pivot shift correlation coefficient younger age operation predicted return greater tegner activity level univariate analysis correlation coefficient regression model significant chondral lesions surgery predicted lower ikdc subjective scores koos scores affect maintenance sports activities conclusion years autologous hamstring acl reconstruction young men predictors greater sports activity level primarily high preinjury activity level reestablishment knee laxity younger age operation moderate chondral lesions lower impact respect
background antibody responses inactivated seasonal influenza vaccine patients atopic dermatitis carefully characterized objective primary objective study compare antibody responses intradermal vaccination participants moderate severe nonatopic participants secondary objectives evaluate effect route administration staphylococcus aureus skin colonization disease severity vaccine response methods open label study conducted influenza season clinical sites total participants moderate severe nonatopic subjects assessed eligibility received intradermal intramuscular vaccination per label followed days vaccination primary outcome difference proportion participants achieving seroprotection hemagglutination inhibition antibody titer day vaccination results seroprotection rates influenza different participants nonatopic participants receiving intradermal vaccination participants receiving intradermal intramuscular vaccination intradermal intramuscular vaccination participants aureus colonization experienced lower seroprotection seroconversion rates lower hemagglutination inhibition antibody titer geometric mean fold increase influenza lower seroconversion rates influenza noncolonized participants conclusion participants colonized aureus exhibited reduced immune response influenza vaccination compared noncolonized participants intradermal intramuscular vaccination patients colonized aureus intramuscular influenza vaccination given preference patients
dha diet endogenous synthesis proposed affect infant development however results inconclusive study aim verify previously observed fatty acid desaturase gene cluster fads snp specific associations erythrocyte dha status month old children sex specific association developmental outcomes study performed children boys obese mothers erythrocyte fatty acid composition analysed blood samples obtained months age developmental outcomes assessed ages stages questionnaire years erythrocyte dha level ranged fatty acids show association fads snp potential determinants regression analysis showed associations erythrocyte dha scores personal social skills problem solving tendency observed association opposite direction minor alleles variant personal social skills respectively became significant snp combined based previously observed effect erythrocyte dha months age sex snp interaction indicated genotype fine motor scores due higher scores among minor allele carrying girls whereas effect seen among boys conclusion dha increasing fads snp erythrocyte dha status consistently associated improved personal social skills small cohort children obese mothers irrespective sex sample small verify potential sex specific effects
schizophrenia without comorbidity confers modest statistically significant elevation risk violence risk considerably increased comorbid antisocial personality disorder psychopathy well comorbid substance use disorders comorbidities frequent conduct disorder conduct disorder symptoms elevate risk aggressive behavior patients schizophrenia violence among adults schizophrenia may follow least two distinct pathways one associated premorbid conditions including antisocial conduct another associated acute psychopathology schizophrenia aggressive behavior bipolar disorder occurs mainly manic episodes remains elevated euthymic patients comparison controls risk violent behavior increased comorbidity borderline personality disorder antisocial personality disorder substance use disorders comorbidities frequent borderline personality disorder bipolar disorder related phenomenology response medication two disorders share tendency impulsiveness impulsive behavior including impulsive aggression particularly expressed occur
paper presents technique reducing input current ripple multiphase power converters provide multiple heterogeneous power supply rails present portable electronics computers asymmetric interleaving individual phases input current ripple reduced compared conventional interleaving technique derived based analytic description relevant current waveforms practical requirements digital control implementation proposed technique analyzed possible performance improvement quantified simulations experimental results proposed technique close reduction input current ripple compared conventional methods demonstrated using experimental prototype comprising microcontroller controls multiphase cmos power management
available cholinergic drugs treating alzheimer disease provide modest symptomatic benefit hypothesized administration peripheral anticholinergic reduce dose limiting adverse effects aes would enable safe tolerable use higher cholinesterase inhibitor doses thus improve antidementia efficacy modified single blind ascending dose phase iia study donepezil plus solifenacin cpc lasting weeks conducted patients probable moderate severity entry criteria included use donepezil dose day preceding months primary outcome measure maximum tolerated dose mtd donepezil achieved protocol limit day administered anticholinergic solifenacin day secondary measures included assessments cognitive global function well aes mean donepezil mtd increased day median day study population safely attained dose end titration markedly reduced donepezil frequency especially gastrointestinal allowed dose increase drug related serious aes clinically significant laboratory abnormalities weeks alzheimer disease assessment scale cognitive component scores efficacy evaluable population improved points baseline estimated points day donepezil points historic placebo clinical global impression improvement scores improved points findings suggest limiting donepezil aes administration solifenacin allows safe administration substantially higher cholinesterase inhibitors doses may augment cognitive global benefits patients
present paper development cyber physical sensing platform monitoring structural tension large bridge cables using mems vibration sensors proprietary wireless technology order implement online tension analysis bridge cables developed improved technology general identification cable tension using gauss newton method determine eigenfrequency order bending stiffness improved identification method applied vertical suspender cables commonly known hangers south section huangpu bridge result shows proposed method effectively estimate cable tension bridge cables different lengths
growing trend universities switch conventional teaching methods focus knowledge transfer methods based concept active learning many methods devised tested show validity concept study project designed implemented teaches simple principles aeronautics students construct fly remote controlled model airplane goals motivate students study mechatronics foster teamwork communication paper explains project effectiveness demonstrated three trials three groups students
physical mechanism light absorbed eye antidepressant energizing effects seasonal affective disorder forms psychiatric major depression scientific interest study designed explore one specific aspect proposed humoral phototransduction mechanism namely carbon monoxide levels increase retinal venous blood response bright light eleven mature male pigs approximately six months age kept days darkness fasted prior surgery following mild sedation anesthesia induced silstic catheters inserted dorsal nasal vein angular vein eye reach ophthalmic sinus venous blood outfiowing eye area collected animals exposed fluorescent generated white light levels blood analyzed gas chromatography min light exposure baseline mean levels retinal venous blood nmol bright light mean levels increased nmol two tailed test study provides preliminary mammalian evidence acute bright light exposure raises carbon monoxide levels ophthalmic venous blood elsevier rights reserved
paper present prototype using dry ionic polymer metal composite ipmc interactive personal devices bracelet necklace pocket key chain mobile devices haptic interaction audio visual feedback possible practical prototype interface electro mechanical system realizes shape changing haptic display information communication dry ipmc change dimensions due electrostatic effect electrical potential provided ipmc operate lower voltage less compatible requirements personal electrical devices mobile devices prototype consists addressable arrays ipmcs different dimensions deformable different shapes proper handling customization printing technology used form supporting parts microcontrollers square digikey imbedded personal device android based mobile app developed talk microcontrollers control ipmcs personal devices receive information signals original shape prototype change another shape related specific sender types information sources interactive prototype simultaneously realize multiple methods conveying haptic information dimension force texture due flexible array design conduct several studies user experience explore users respond shape change information
objectives previous state interagency collaborations led successful tobacco cessation initiatives objective study assess roles interaction state medicaid public health agency efforts support tobacco cessation low income medicaid beneficiaries methods interviewed medicaid state public health agency officials states september october collaborations policy development implementation medicaid tobacco cessation including medicaid coverage policies quitlines monitoring results collaboration medicaid public health agencies limited smoking cessation quitlines common area collaboration cited public health officials typically involved developing medicaid coverage policies states covered range food drug administration approved tobacco cessation medications states imposed limitations charging copayments requiring previous authorization states generally lacked data monitor implementation tobacco cessation efforts little ability determine effectiveness policies conclusions strengthen efforts reduce smoking tobacco related health burdens monitor effectiveness policies programs medicaid public health agencies prioritize tobacco cessation develop analyze data smoking cessation efforts among medicaid beneficiaries recent multistate initiatives centers disease control prevention centers medicare medicaid services seek promote stronger collaborations clinical prevention activities including tobacco cessation
article discusses practices parental support maternity healthcare provided welfare state drawing ethnographic material clinics finland discuss maternity healthcare practices processes specific contexts subjectification parenthood nordic welfare state analysis shows nurses work experience based knowledge populationstatistical knowledge parental competence achieved largely natural process experiencing pregnant life care practices seen enabling parenthood respect process clinics encourage parents self reflect self reliant emphasis self reflection self reliance previously interpreted state adoption therapy culture response market demands welfare state offer require citizens autonomy choice argue however parental subject emerging practices welfare service reduced neoliberal reflexive individual parenthood individual project blame individual shortcomings equally mere disciplined product governmentality pushed conform idealised parent figure derived collective ideas good parenthood
paper deals application simulated inductor continuous time allpass filters group delay sensitivity analysis realized filter realization filter pair based lcr resonator circuits employs single generalized grounded impedance converter implemented one operational amplifier group delay sensitivity measure useful comparison second order allpass filter cells used continuous time filter pair design related well known pole factor pole frequency sensitivities simple analytic expression design procedure developed tuning achieved trimming resistors
paper describes wearable encounter type haptic device suitable combined usage visual display features device lie driving mechanism enables encounter type haptic display compact implementation entire device including driving mechanism driving mechanism displays natural haptic sense based smooth transition follow constraint finger movements compactness important contributes preserving quality visual information used together visual display test basic performance device response driving mechanism evaluated haptic display function evaluated simulation device used touch object computer graphics space
trisomy syndrome rare disorder carries high mortality rate due abnormal prenatal development resulting serious birth defects although genitourinary malformations commonly seen trisomy syndrome knowledge association cloacal exstrophy trisomy extremely rarely reported herein newborn trisomy syndrome multiple congenital anomalies including cloacal exstrophy presented importance structural anomalies neutrophilic leukocytes blood smear supporting diagnosis trisomy discussed
honeypots honeynets popular tools area network security network forensics deployment usage tools influenced number technical legal issues need carefully considered paper outline privacy issues honeypots honeynets respect technical aspects paper discusses legal framework privacy legal grounds data processing also discuss address law considered personal data analysis legal issues based law supported discussions privacy related issues
obstructive sleep apnea osa common sleep related breathing disorder characterized repetitive episodes complete partial obstruction upper airway prevalence disorder strictly dependent gravity events apnea hypopnea index ahi ranges general population higher rates men increasing age hypoxia induced osa severely affects structure function blood vessels culminating mortality morbidity negative impact influences also cognitive functioning recent papers showed relationship osa neurological disorders neurodegenerative diseases stroke epilepsy headache osa may accelerate onset mild cognitive impairment alzheimer disease might also represent independent risk factor parkinson disease osa also frequent multisystem atrophy early stages continuous positive airway pressure cpap treatment might slow progression disease thus highlighting potential importance osa screening timely intervention patients moreover cpap effective reducing daytime sleepiness osa may induce seizures means sleep disruption deprivation well cerebral hypoxemia consequent oxidative stress demonstrated cpap treatment efficacious controlling epileptic seizures osa represent risk factor stroke death mainly related endothelial dysfunction formation atherosclerosis caused hypoxia oxidative stress cpap treatment patients osa stroke delivered early stages able increase magnitude neurologic improvement vascular accident strong association osa headache particular sleep apnea headache described recurrent morning headache resolution effective treatment sleep apnea review clearly shows importance taking asleep history neurological patients considering diagnosis specific treatment osa patients
paper focuses real time estimation ion state charge soc first principles model validated experimental data literature chosen mimic real ion cell impedance responses different socs studied simulated electrochemical impedance spectroscopy eis equivalent circuit model developed estimator design parameters including lumped series resistances lumped interfacial resistances time constant tau derived system identification compared eis results estimator designed using extended kalman filtering ekf implemented first principles model demonstrated computer simulation soc charge discharge cycles estimated relative error accuracy soc tracking improved jointly estimated along either given model parameters vary soc revealed eis elsevier ltd rights reserved
paper describes development construction energy harvesting device provide safe reliable source electrical energy onboard gravity dropped weapons aerial bombs generators collect store mechanical energy weapon falls away aircraft weapon fallen away aircraft stored mechanical energy released generating electricity hybrid piezoelectric electromagnetic generation method design construction testing generator discussed length conceptual designs integrating described energy harvester alongside current alternative sources electrical power also discussed
backgroundearly life exposure older siblings associated lower risk asthma date study addressed impact siblings airway fecal microbiota infancy aim study therefore profile nasal airway fecal microbiota infants examine association siblings microbiota profile methodswe conducted cross sectional study healthy infants aged year using rrna gene sequencing unbiased clustering approach nasal airway fecal samples identified microbiota profiles determined association siblings microbiome profile resultsoverall median age months iqr months siblings household unbiased clustering nasal airway microbiota identified three profiles moraxella dominant corynebacterium dolosigranulum dominant mixed infants siblings likely moraxella dominant profile corynebacterium dolosigranulum dominant profile without siblings opposite pattern multivariable adjusted fecal microbiota consisted three profiles bifidobacterium dominant escherichia dominant enterobacter dominant infants siblings likely bifidobacterium dominant profile escherichia dominant profile without siblings opposite pattern multivariable adjusted conclusionsin cross sectional study infants siblings likely moraxella dominant nasal microbiota profile bifidobacterium dominant fecal microbiota profile findings facilitate investigation interplay early life environmental exposure microbiome childhood asthma
background number different manifestations pulmonary aspergillosis study aims review radiology presentation histological features lung nodules caused aspergillus spp methods patients identified cohort attending specialist chronic pulmonary aspergillosis clinic patients cavitating lung lesions without fibrosis aspergillomas diagnosis invasive aspergillosis excluded demographic laboratory clinical data radiologic findings recorded results thirty three patients pulmonary nodules diagnostic features aspergillosis histology laboratory findings identified eighteen male mean age years range years former current smokers median charleston morbidity index range complained least one dyspnoea cough haemoptysis weight loss none reported fever ten patients elevated aspergillus igg patients elevated aspergillus precipitins twelve patients single nodule six patients nodules nodules nodules mean size nodules maximum size ranging nodules cavitation radiographically upper lobes commonly involved histology available patients showed evidence granulation tissue fibrosis visualisation fungal hyphae conclusion pulmonary nodules less common manifestation aspergillosis immunocompetent patients distinguishing nodules lung pathology may difficult findings alone
purpose suburethral tapes standard surgical treatment stress urinary incontinence aim study evaluate subjective objective cure rates years tension free vaginal tape obturator procedure materials methods patients underwent tension free vaginal tape obturator procedure total centers invited followup objective cure defined negative cough stress test subjects completed khq king health questionnaire ioq incontinence outcome questionnaire fsfi female sexual function index questionnaire pgi patient global impression improvement results overall women alive available clinical examination completed questionnaires objective cure rate women examined clinically cured undergone reoperation recurrent persistent stress urinary incontinence treatment counted failed women study purposes subjective cure reported women three patients vaginal tape extrusion time clinical examination extrusion small asymptomatic require treatment cumulative extrusion rate six women undergone reoperation tension free vaginal tape obturator associated complications experienced novo overactive bladder conclusions subjective objective cure rates years tension free vaginal tape obturator procedure respectively vaginal extrusion rate study slightly higher series major long term complications appeared rare
investigation paper dimensional variable coefficient kadomtsev petviashvili equation describes propagation surface internal water waves virtue binary bell polynomials symbolic computation auxiliary independent variable bilinear forms soliton solutions backlund transformations lax pair obtained variable coefficients equation affect solitonic structure specially chosen curved linear solitons illustrated elastic collisions among two three solitons discussed solitons keep original shapes invariant except phase shifts
work proposes include security privacy context linked open data lod semantic web database partitioning approach logically physically separate data distribute partitions across several different cloud providers applied data distribution called fixed vertical partitioning distribution approach fvpd data schemes vertically partitioned distributed across various different cloud providers hence framework uses security distribution approach storing sensitive data securely privacy ware possible cloud deployment models thus provides solution improve level security privacy proposed fvpd approach also becomes viable context lod semantic web furthermore relevant literature approach context dealing security privacy far therefore work transfers fvpd approach relational databases semantic web frameworks apache jena sesame etc provide storage engines rdf data corresponding sparql endpoints query performance federated environment compared non partitioned non distributed environment adapted version tpc benchmark used thus work shows query performance affected relational database data exposed sparql endpoints rdf based form fvpd approach influences query performance finally illustrates mechanism improve level security privacy security distribution approach
rheumatoid arthritis chronic autoimmurie disease affect joints muscles result noticeable disruption joint structure function early diagnosis crucial preventing disease progression however complicated task general practitioners gps due wide spectrum symptoms progressive changes disease direction time order assist physicians minimize possible errors due fatigued less experienced physicians study proposes advanced decision support tool based consultations group experienced medical professionals orthopedic surgeons rheumatologists using well known soft computing method called fuzzy cognitive maps fcms first set criteria diagnosis based previous studies consultation medical professionals selected particle swarm optimization pso fcms along medical experts knowledge used model problem calculate severity disease finally small scale test conducted shohada university hospital iran evaluating accuracy proposed tool accuracy level tool reached results closely matched medical professionals opinions considering obtained results real practice believe proposed decision support tool assist gps accurate timely diagnosis patients ultimately risk wrong late diagnosis diminished patients disease may prevented moving advanced stages
new framework electromagnetic theory presented basis conservation principles energy momentum first maxwell equations lorentz force law vacuum derived theorems conservation principles next new kinds averaging procedure transversal longitudinal introduced deal macroscopic media electromagnetic field flux density defined longitudinal transversal averages corresponding microscopic field polarization magnetization defined epsilon given explicit expressions terms microscopic electromagnetic structure matter lorentz transformation space time electromagnetic field derived entirely within framework electromagnetic theory
purpose purpose study report case ocular infection gliocladium species due exposed scleral buckle design interventional case report used study design methods year old diabetic male patient presented persistent pain redness discharge left eye since months treated previously topical systemic steroids diagnosis autoimmune scleritis undergone scleral buckling surgery cryotherapy inferior rhegmatogenous retinal detachment past best corrected visual acuity right left eyes respectively retraction left lower lid revealed exposed scleral buckle overlying necrotic conjunctiva scleral buckle removal done microbiological examination showed gliocladium species growing blood agar sabouraud dextrose agar treatment started topical antifungal medication oral antibiotics results following treatment signs infection showed resolution patient underwent retinal reattachment surgery favorable anatomic visual outcome conclusion ocular infection gliocladium species previously reported poor response steroids uncontrolled diabetes make clinician aware possible fungal infection removal scleral buckle identification causative organism use appropriate antibiotics important accurate management case
review current knowledge anterior cruciate ligament acl injury prevention acl rehabilitation individuals yet reached musculoskeletal maturity narrative review based targeted systematic literature search paediatric acl injury risk factors injury prevention rehabilitation search strategies resulted hits risk factor studies hits prevention hits rehabilitation modifiable risk factors acl injury largely unknown paediatric population acl injury prevention using neuromuscular training highly successful adolescent population existing injury prevention programmes cost effective efficacy acl injury prevention programmes children however investigated markedly lesser degree paediatric acl injury rehabilitation poorly described although supervised active rehabilitation progressed phases functional milestones generally encouraged although limited current evidence supports implementation injury prevention programmes female football players age supervised active rehabilitation progression guided functional milestones also advocated future identification modifiable risk factors needed design prevention programmes younger children need international multicentre studies treatment algorithms rehabilitation increase knowledge short long term outcomes following existing algorithms narrative review level iii
paper presents analyses represented system overlay hvdc network based multi terminal vsc state space representation method automatic development small signal model hybrid system achieved methodology develop small signal model composed four steps construction sub system units development state space models unit linearization nonlinear models integration linearized models control architecture schemes vsc systems also presented order obtain control objectives control active reactive power voltages based developed platform small signal stability analyzed investigate effect different control strategies well controller parameters system performance
reliable multi channel neural recording critical neuroscience research clinical treatment however hardware development fully integrated multi channel wireless neural recorders date still proof concept stage ready practical use trade offs performance power consumption device size robustness compatibility need carefully taken account paper presents optimized wireless compressed sensing neural signal recording system system takes advantages custom integrated circuits universal compatible wireless solutions proposed system includes implantable wireless system chip soc external wireless relay soc integrates channel low noise neural amplifiers programmable filters gain stages sar adc real time compressed sensing module near field wireless power data transmission link external relay integrates bit low power microcontroller bluetooth wireless module programming interface inductive charging unit soc achieves high signal recording quality minimized power consumption reducing risk infection skin connectors external relay maximizes compatibility programmability proposed compressed sensing module highly configurable featuring sndr compression ratio soc fabricated standard cmos technology occupying silicon area pre implantable system assembled demonstrate proposed paradigm developed system successfully used long term wireless neural recording freely behaving rhesus monkey
exclusive enteral nutrition established initial therapy induce remission active crohn disease especially children mechanisms action therapy yet fully defined intestinal alkaline phosphatase iap recognised marker enterocyte differentiation implicated innate gut immune response enteric pathogens using caco human adenocarcinoma cell line study showed incubation human cells polymeric formula resulted dose dependent increase expression iap cell surface investigation required determine pathway involved finding suggests cell surface associated iap may aspect gut innate immune response pathogenic bacteria strengthened setting
significant perform damage identification wind turbine using running condition data guaranteeing safe operation acquired condition data usually mixed heavy background noise feature enhancement noise elimination method necessary task nonlocal means algorithm increase signal noise ratio without destroying original frequency spectrum structure reserve useful information farthest meanwhile eliminate noise seems possible powerful tool along demodulation technique constant speed condition order tracking analysis method variable speed condition damage identification however actual application cases show would obtain entirely satisfying results face strong background noise situation specialization improved nonlocal means method developed damage identification generator bearing based analyzing essence characteristic mechanical vibration signal reasonable ideas algorithm design neighborhood selection variation weighting function nonlocal means denoising task proposed effectiveness specialization improved nonlocal means method verified fault identification cases study including variable speed condition elsevier ltd rights reserved
procedure based multiple expansion brain electrical generator used derive analytical expressions transfer matrix necessary obtain potentials referenced infinity features include avoidance computations involve large number discrete dipole sources faster evaluation compared use dipole layer transparency showing parameters constitute transfer matrix paper also proposes construction standardization matrix without use general inverse non symmetrical matrix
angiogenesis important process involved pathogenesis psoriasis promises new potential parameter diagnosis screening treatment study investigated levels signal peptide cub egf epidermal growth factor like protein family domain containing protein scube potential value novel marker angiogenesis patients psoriasis also evaluated assessing possible relation scube disease activity conjunction vascular endothelial growth factor vegf levels established marker angiogenesis forty eight patients psoriasis aged years age gender matched healthy controls included detailed information obtained history physical examination psoriasis area severity index pasi scores calculated blood scube vegf levels measured enzyme linked immunosorbent assay mean pasi score patients patients serum scube vegf levels significantly higher controls sensitivity specificity calculated cut level scube cut level scube respectively cut vegf level predicted presence psoriasis sensitivity specificity results pioneering study indicate scube protein family appears probable role pathogenesis angiogenesis development psoriasis scube may novel markers angiogenesis psoriasis
objective investigate headache related serum melatonin levels melatonin excretion rhythmicity patients hypnic headache background strict sleep dependency headache attacks pathognomonic feature changes melatonin levels marker circadian rhythm assumed play pivotal role pathophysiology methods serum melatonin levels acquired nine patients nine age gender matched healthy controls hour time period time headache results significant changes melatonin levels could detected comparing patients healthy controls melatonin excretion rhythmicity significantly altered patients mean melatonin level patients controls headache time conclusion study able confirm significant role melatonin concentration changes pathophysiology vetoes melatonin deficiency plays major role pathophysiology disorder
article addresses common psychopathological self injurious behaviors adolescents article utilizes cognitive behavioral theoretical approach includes functional analysis proposed objective analyze pathologies associated self injurious behaviors relevant descriptive explanatory variables study looks personal history information stable personality characteristics consequences associated self injurious behavior includes self harm without suicide also specifies key mechanisms self injurious behavior negative self concept self esteem forms taken self harm intentionality finally article utilizes case study teenager borderline personality disorder exemplify outlined self injurious behaviors traits addressed article
intra uterine device iud one birth control methods available nulliparous women even though misconceptions still remain medical popular opinion nulliparous iud contraception france second methods used women pill best contraception one chosen women however choice nulliparous iud may really difficult despite increasing number women wishing use long acting reversible contraceptives utilization including iud probably one issues decrease unintended pregnancies exhaustive clear information iud necessary allow informed real choice prescription must consider contraindications medical conditions safe insertion especially avoid infection screening std chlamydia trachomatis nesseria gonorrhoeae nulliparous women years old insertion must effected usual precautions short iud preferred even side effects expulsion pelvic pains dysmenorrhea frequent nulliparous iud first intention choice contraception consider women could obtain easily including emergency contraception situation elsevier masson saselsevier masson sas rights reserved
perceptual systems must rapidly generate accurate representations world sensory inputs corrupted internal external noise typically obtain veridical representations integrating information multiple channels integration lead biases inputs fact source although considerable amount known different sources information combined influence perceive known whether temporal features combined vital address question given divergent predictions made different models cue combination time perception concerning plausibility cross modal temporal integration implications integration would research programs action control social cognition present four experiments investigating influence movement duration perceived duration auditory tone participants either explicitly experiments implicitly experiments produced hand movements shorter longer durations judging duration concurrently presented tone duration across experiments judgments tone duration attracted toward duration executed movements tones perceived longer executing movement longer duration results demonstrate temporal information associated movement biases perceived auditory duration placing important constraints theories modeling cue integration state estimation well models time perception action control social cognition
background aimed show frailty status older patients find association frailty scores cha vasc bled ultimately sought investigate impact frailty cardiovascular cause mortality older patients methods retrospectively evaluated patients years old underwent comprehensive geriatric assessment cga single tertiary hospital cha vasc bled scores calculated based electronic medical records frailty index computed cga data primary outcomes cardiovascular cause mortality results frailty status positively associated cha vasc score hasbled score patients high cha vasc bled scores likely treated anticoagulants rather antiplatelet agents however frailty status associated antithrombotic therapy follow period median interquartile range months patients died due cardiovascular events cha vasc score could predict cardiovascular mortality cause mortality contrast frailty status independent predictor cardiovascular cause mortality adjusting possible confounders hazard ratio cause mortality conclusion frailty assessment used predict mortality older patients provides additional prognostic value along cha vasc bled scores elsevier ireland ltd rights reserved
individuals moderate severe traumatic brain injury tbi shown experience significant problems facial affect recognition far however known impairments relate overall functioning quality life qol following tbi aim current study test hypothesis worse performance far task would associated reduced qol related social emotional functioning worse mood increased fatigue forty seven individuals tbi healthy controls hcs completed facial emotion identification task feit well questionnaires assessing social emotional qol mood fatigue tbi group performed significantly worse hcs feit significant relationship far fatigue qol related social emotional functioning documented unexpected direction individuals performed better feit reported poorer qol greater fatigue individuals better far may require increased effort perform task thus experience greater fatigue poorer social emotional qol
family policies france various european countries like pension schemes involve mechanisms compensate inequality women men associated organization family compensation sometimes tied directly marriage broadly couple sometimes parental investment time devoted maintenance welfare family members article examine principles compensation applied legislation five european countries characterized different social protection systems use concept familialization characterize rationales underlying women social rights different systems understand processes connecting developments family social policies dual process familialization parental activities specialization gender roles
pregnancy sickness widespread yet etiology poorly understood almost certainly endocrine origin likely product placental hormones human chorionic gonadotropin strongest candidate long known greater levels nausea vomiting pregnancy associated lower incidence spontaneous abortion yet causal mechanisms remain unclear one current popular explanation nausea vomiting pregnancy fetoprotective inducing aversions foods especially meat dairy seafoods may carry toxins pathogens mutagens however spontaneous abortions arise genetic epigenetic defects present near conception moreover measurements human chorionic gonadotropin hcg time implantation particularly hyperglycosylated isoform accurately predict subsequent spontaneous abortion thus developmental fate embryos fixed onset symptoms pregnancy sickness alternative explanation link pregnancy sicicness spontaneous abortion embryo quality hypothesis high quality embryos likely produce biochemical antecedents pregnancy sickness avoid spontaneous abortion recent work shown link pregnancy sickness spontaneous abortion grows stronger maternal age dramatically mothers older reflects parallel rise incidence autosomal aneuploidies maternal age link pregnancy sickness spontaneous abortion exists nausea vomiting pregnancy fetoprotective nausea vomiting index high quality embryo pregnancy sickness adaptive per result antagonistic pleiotropy thyroid function embryos use hcg modulate maternal thyroid hormone production gestation embryos benefit thyroid hormone production key neurodevelopment produce maternal nausea vomiting product pregnancy sickness however may still serve protect embryo quality different mechanism posited meph embryo quality protected calibrating dietary intake micronutrient iodine critical neuromotor development humans evolutionary history iodine short supply iodine deficiency still common source cognitive impairment across globe thus interest food aversions commonly associated pregnancy sickness meat dairy seafoods also chief dietary sources iodine intriguing property iodine little much early pregnancy damaging embryo brain development given pregnancy sickness closely linked iodine intake thyroid function hypothyroidism associated lower levels nausea vomiting hyperthyroidism obvious interpretation emerges previously described link diet pregnancy sickness pregnancy sickness less likely plants particularly corn maize sole food staples arises plant food staples safe previously suggested foods iodine poor may addition goitrogenic pregnancy sickness reduces dietary intake iodine clearly maladaptive conditions iodine deficiency hypothyroidism conversely higher levels pregnancy sickness induced hyperthyroidism may protect embryos inimical effects excessive dietary iodine early gestation reducing intake iodine rich foods elsevier inc rights reserved
background unintended pregnancy continues major public health concern particularly among women years age emergency contraception became available purchase without prescription united states however use among women risk unintended pregnancy adequately explored therefore purpose project gain insight perceptions experiences college women regarding counter emergency contraception since change status methods study used descriptive exploratory qualitative design small group interviews conducted early obtain data women ages currently attending college purchased data analyzed using content analysis findings participants aware emergency contraception availability counter although certain gaps knowledge exist decision making related use driven recognition pregnancy risk strong desire prevent unintended pregnancy confidentiality major concern lack access women age participants noted limitations health services provision education conclusions although women awareness availability comprehensive knowledge needed barriers use exist particularly confidentiality age related restrictions increasing awareness personal risk unintended pregnancy particularly among college women important elsevier rights reserved
three dimensional computer aided design cad models different levels detail lod used various industries numerous purposes therefore necessary develop techniques simplify cad models order adjust lod model according purpose main purpose simplification minimize change outer shape models reduce data size models key technologies achieve purposes evaluation metrics simplification operation evaluation metrics employed select elements preserved removed calculating importance geometric elements comprising cad model simplification operation removes selected elements fills void model caused removal feature volume type popular criteria used evaluation metrics simplification feature based cad models study concept feature shape complexity fsc introduced method adopting fsc criterion evaluation metrics presented prototype system simplification cad models implemented finally effectiveness proposed method verified conducting simplification experiments complex cad assembly model
bisphosphonates increasingly used treat pediatric patients skeletal disorders however effects long term bisphosphonate therapy cessation therapy growth unclear thus studies undertaken determine effects alendronate discontinuation treatment cbl mice period rapid skeletal growth compared vehicle treated mice weeks alendronate treatment starting age days resulted fold increase trabecular bone setting suppressed bone formation alendronate therapy weeks followed weeks vehicle treatment resulted pronounced increase trabecular bone compared mice treated alendronate weeks fold vehicle treated controls fold mice received alendronate weeks followed weeks vehicle exhibited increased osteoblast surface fold mineralizing surface fold bone formation rate fold compared mice treated continuously alendronate however parameters restored levels observed vehicle treated mice thus partial resumption bone formation upon cessation bisphosphonate therapy leads greater increase trabecular bone found bisphosphonates administered continuously growing mice data suggest intermittent administration bisphosphonates may optimize beneficial effects growing skeleton american society bone mineral research
paper modular platform provides student services smart educational environment described platform represents point mutual integration various services hosting platform students projects platform integrating sms service students web applications internet things platform enables acquiring data sensors distributed within university building controlling various actuators platform deployed part smart learning environment integrated single sign service uses cas oauth rest api also provided php symfony framework relational non relational databases used deploying platform platform evaluated tested
implementation patient centered treatment interprofessional health care units rehabilitation teams external participation interaction patient health care professionals internal participation communication coordination cooperation interprofessional team need considered aim study identify preferences patients health care professionals concerning internal external participation rehabilitation clinics order develop interprofessional shared decision making sdm training program health care professionals enhance types participation therefore cross sectional mixed methods study implemented four rehabilitation clinics study consists two parts focus groups patients survey experts senior health care professionals medicine psychotherapy physical therapy nursing time respect health care professionals desire participation decision making processes mentioned frequently patients focus groups health care professionals saw deficits internal participation management feedback talking difficult team members moderate conflict discussion results assessments used develop interprofessional sdm training program implementing internal external participation interprofessional teams medical rehabilitation
aim assess accuracy magnetic resonance enterography predicting extension location characteristics small bowel segments affected crohn disease method prospective study including consecutive series patients crohn disease small bowel underwent surgery specialized colorectal unit tertiary hospital preoperative magnetic resonance enterography performed patients following homogeneous protocol within months prior surgery thorough exploration small bowel performed surgical procedure calibration spheres used according discretion surgeon accuracy magnetic resonance enterography detecting areas affected crohn disease small bowel assessed findings magnetic resonance enterography compared surgical pathological findings results thirty eight patients lesions included study surgery lesions described magnetic resonance enterography found seven detected exclusively use calibration spheres passing unnoticed surgical exploration magnetic resonance enterography accuracy detecting location stenosis sensitivity specificity magnetic resonance enterography precisely diagnose presence inflammatory phlegmon accuracy accurate detecting abscesses fistulas accuracy respectively conclusion magnetic resonance enterography useful tool preoperative assessment patients crohn disease however thorough intraoperative exploration entire small bowel still necessary
background objectives study compare peri operative long term outcomes oesophageal cancer arose previously radiated field ecrf versus primary pec among ecrf patients radiotherapy induced riec versus non radiotherapy induced nriec methods data collected european centres two thousand four hundred eighty nine patients surgically treated included pec group ecrf group nriec group riec group propensity score matching analyses used compensate differences baseline characteristics results compared pec group ecrf group characterised less use neoadjuvant chemoradiotherapy versus less pathological stage iii versus greater incidence margins versus increased hospital mortality versus overall morbidity versus matching year overall versus hazard ratio confidence interval event free versus survivals significantly reduced ecrf group significant differences incidence pattern tumour recurrence comparing riec nriec groups significant differences short long term outcomes matching conclusions ecrf associated poorer long term survival related reduced utilisation neoadjuvant chemoradiotherapy increased incidence tumour margin involvement surgery outcomes appear dictated limitations related previous radiotherapy administration radiotherapy induced carcinogenesis elsevier ltd rights reserved
past decade research carbon nanotubes revealed potential advances thermal engineering applications present study investigates radiative absorption reflection vertically aligned carbon nanotubes vacnts broad spectrum near infrared far infrared regions optical constants vacnt modeled based dielectric function graphite effective medium approach treats cnt film homogenized medium calculated radiative properties show characteristics near unity index matching high absorptance around wavelength packing density degree alignment shown affect predicted radiative properties brewster angle penetration depth vacnts examined infrared spectrum radiative properties vacnt thin films also evaluated showing reduction absorptance near infrared due transmission film thicknesses less study provides better understanding infrared behavior vacnt may guide design applications energy harvesting space borne detectors stealth technology
introduction cysticercosis caused taenia solium cysticerci located mainly central nervous system causing neurocysticercosis venezuela epidemiological studies disease conducted objective determine seroprevalence risk factors cysticercosis two rural communities anzoategui state material methods conducted survey collect data possible risk factors signs symptoms disease took samples two communities boqueron punto lindo detection igg antibodies solium cysticerci performed elisa results seroprevalence boqueron due low number seropositives statistical analysis possible however three seropositive persons knowledge disease history consumption undercooked pork meat presence headache punto lindo seroprevalence significant differences sex age however found seropositives among individuals younger years regard risk factors signs symptoms significant associations found consumption undercooked pork headaches seizures visual problems conclusions results showed low transmission cysticercosis boqueron high punto lindo high prevalence children suggests recent transmission
frequent empirical observation cold induced counter irritation may attenuate itch aim randomized single blinded exploratory study evaluate counter irritation effects cold stimulation topical application transient receptor potential trpa agonists trans cinnamaldehyde lmenthol respectively histamine induced itch wheals neurogenic inflammation healthy volunteers histamine applied volar forearms using skin prick test lancets recorded outcome parameters itch intensity wheal reactions neurogenic inflammation measured laser speckle perfusion imaging homotopic thermal counter irritation performed temperatures ranging degrees degrees using thermal stimulator chemical cold like counter irritation conducted men thol trans cinnamaldehyde doxepin used positive antipruritic control comparator cold counter irritation stimuli degrees degrees inhibited itch stimulus intensitydependent manner lesser extent also wheal reactions neurogenic inflammation chemical cold like counter irritation lmenthol trans cinnamaldehyde antipruritic efficacy similar doxepin cold induced counter irritation inhibitory effect histaminergic itch suggesting agonists cold transduction receptors could potential antipruritic value
computer graphics remains one exciting rapidly growing computer fields includes geometry processing major part every element graphics processed using different algorithms acquisition reconstruction analysis manipulation simulation transition simple primitive complex structures one commonly used function cropping clipping geometrical objects paper approach proposed cropping object algorithm allows users crop selective portions geometrical objects based certain constraints like axis position amount cropped proposed algorithm provided plugin open source software openflipper results crop algorithm presented
purpose study face shrinking opportunities children older adults routinely interact one another sometimes result adolescent geographies age segregated gated communities families geographical mobility many communities introduced intergenerational programs within school curriculum decade one massachusetts community maintained intergenerational program brings fourth grade students together older adults question students involvement intergenerational program lessened ageist beliefs years later design methods quasi experimental research design examined images aging held students grew neighboring towns attend regional high school participants completed brief questionnaire results separate regression analyses positive negative images aging controlling students frequency self reported quality interaction older adults ethnicity age gender reveal town difference students positive negative images aging implications certain high school students one community ongoing intergenerational programming hold positive image older adults research needed parse exactly short long term legacy effects arise young students opportunity interact closely older adults grandparents neighbors
recent years electricity crisis still becomes noticeable countries due widening gap demand supply consequently future demand plays significant role efficient management utilization electricity pertaining efficient supply handling increase power system reliability electricity demand forecasting one crucial tools forecasting technique used decision makers world predict future demand key information proper policy research hybrid model consists maximal overlap discrete wavelet transform modwt support vector machine svm differential evolution optimization emphasizing simplifying complex structure data pre processing proposed forecast thirty two annual electricity consumptions compared traditional forecasting models hybrid model modwt svm combined model svm optimization based mean absolute error mae mean absolute percentage error mape symmetric mean absolute percentage error smape measures well friedman test post hoc test empirical results indicate proposed model outperforms forecasting models provides accurate forecasts candidate models significance levels nearly highest precision consequently proposed model able reduce limitations individual models regarding annual electricity consumptions used promising tool order forecast annual electricity consumptions well elsevier rights reserved
background study results shown chronic exposure cigarette smoke affects taste function humans however neither quantitative impact taste sensitivity time course taste recovery stopping smoking precisely examined methods experimental design included phases case control phase comparing taste sensitivity level measured electrogustometric egm thresholds various parts tongue locus smokers non smokers follow study looking taste sensitivity recovery smokers smoking cessation compared non smokers results smokers exhibited significantly lower taste sensitivity non smokers higher nicotine dependence fagerstrom scores lower taste sensitivity smoking cessation egm thresholds decreased progressively reached taste sensitivity range non smokers depending locus time weeks recovery could observed tip edge loci recovery posterior loci complete weeks dorsal loci recovery observed months conclusions smoking cessation lead rapid recovery taste sensitivity among smokers recovery time found differ based sensitivity loci tongue use egm could potentially explored motivational tool smoking cessation
aim paper study conservative wave equation coupled diffusion equation coupled system naturally arises musical acoustics viscous thermal effects wall duct wind instrument taken account resulting equation known webster lokshin model variable coefficients space fractional derivative time equation recast port hamiltonian framework using diffusive representation fractional derivative time multiscale state space representation port hamiltonian formalism proves adequate reformulate coupled system could enable another well posedness analysis using classical results port hamiltonian systems theory european control association published elsevier ltd rights reserved
using daily fluctuations local sunshine instrument sentiment study effect day day decisions lower level financial officers positive sentiment associated higher credit approvals negative sentiment opposite effect larger magnitude effects stronger financial decisions require discretion reviews less automated capital constraints less binding variation approval rates affects post financial performance produces significant real effects analysis economic channels suggests sentiment influences managers risk tolerance subjective judgment elsevier rights reserved
multiple sclerosis chronic autoimmune disease common cause nontraumatic disability young people etiology disease well defined yet cytoldnes play important role differentiation maturation survival wide range cells including cells immune system suppressor cytokine signaling socs proteins important regulators cytokine signaling pathway aim present study compare expression levels socs socs socs socs genes blood relapsing remitting patients healthy controls taciman quantitative real time pcr patients healthy control group observed socs socs expression significantly regulated respectively whereas significant difference observed patients controls socs socs gene expression respectively addition significant correlation expression socs socs socs socs genes clinical findings level physical disability patients according kurtzke expanded disability status scale edss criterion disease duration however significant positive correlation observed expression levels socs genes study shows loss balance among various members socs family proteins may contribute pathophysiology multiple sclerosis elsevier rights reserved
microbial fuel cell mfc promising way remove organic pollutants hexachlorobenzene hcb widely used agricultural pesticide study single chamber membrane less soil mfcs constructed hcb degraded pentachlorobenzene pecb tetrachlorobenzene tecb trichlorobenzene tcb sequence reductive dechlorination process soil mfcs influences external resistance concentration phosphate buffer electrode spacing soil mfcs degradation rate removal efficiency hcb analyzed results showed degradation rate removal efficiency hcb increased external resistance decreased also concentration phosphate buffer increased anode area played significant role dechlorination hcb altering spacing reducing electrode resulted lower ohmic resistance soil mfcs ohmic resistance negatively correlated removal efficiency degradation rate conclusion hcb removal efficiency could enhanced soil mfcs performance improved decrease external resistance internal resistance increase phosphate buffer concentration rather shortening electrode spacing
objectives people living psychotic illness higher rates cigarette smoking face unique barriers quitting compared general population examined whether self reported reasons smoking useful predictors successful quit attempts among people psychosis methods part randomized controlled trial addressing smoking cardiovascular disease risk behaviors among people psychosis self reported reasons smoking assessed baseline weeks months three factors reasons smoking questionnaire coping physiological stimulation activation entered model predict short long term abstinence relationship factors mental health symptoms also assessed results participants scoring higher stimulation activation factor control weight enjoyment concentration peps baseline less half likely abstinent weeks female participants five times likely abstinent weeks higher global functioning baseline likely abstinent positive correlation changes time stimulation activation factor baseline month follow brief psychiatric rating scale total score month follow indicates increasingly higher endorsement factor associated psychological symptoms also negative correlation change time stimulation activation factor global functioning months indicating increasingly higher endorsement factor led lower global assessment functioning conclusions stimulation activation factor may particularly important assess address among smokers psychosis recommended research use reasons smoking questionnaire among smokers psychosis clinical tool identify specific quit barriers research females higher smoking cessation rates short term relapse prevention interventions seem worthy investigation
study undertakes empirical exploration attitudes towards tax evasion welfare fraud new zealand prior research indicates society different attitudes towards two crimes however known case particularly crimes conceptually similar study two aims first measure extent society views tax evasion welfare fraud differently new zealand second primary objective research offer explanation different views exist dual process model using social dominance orientation right wing authoritarianism used analytical purposes responses survey participants show new zealanders different attitudes towards welfare fraud tax evasion contrast previous research findings study shows harsher attitudes held towards tax evasion welfare fraud education income level provide greatest level significance explaining attitudes towards welfare fraud age income source provide greatest level significance explaining attitudes towards tax evasion
standards reflect consensus semantics terms used communicate whether people software systems standards ensure communication correct different standards different semantics terms express common concepts using different terms different ways communication software systems based different standards sometimes difficult achieve standards integration concerns explicit representation overlapping sets concepts standards differences semantics ensure standards used consistently together turn enables software based integrated standards interoperate reducing cost software integration standards conformance determines whether interpretation standardized terms used software applications consistent semantics given standards paper proposes general architecture design ontologies standards integration conformance manufacturing engineering ontology architecture divided four levels vendor standards domain core manufacturing turning tools used case study illustrate approach finally paper offers short examples first order logic propositions
electrochemical impedance spectroscopy cyclic voltammetry techniques employed study borohydride oxidation polycrystalline electrode aqueous alkaline media containing nabh naoh determined current density changes interpreted combination eis measurements regions decreasing anodic current leading negative polarization resistance supposed appreciably related increasing availability oxygen containing species ohad oxides surface presence accumulated borohydride species possible borohydride oxidation processes electrical circuits discussed regarding potential applied
fish reproduction previous information ovary oocyte distribution necessary oocytes quantitative estimates required estimate batch annual fecundity heterogeneous oocyte distribution requires standardized sampling protocol prevent bias estimates whereas homogeneous distribution allows sampling portion gonads risk bias studied gonad oocyte distribution patterns hogfish lachnolaimus maximus population southern gulf mexico mature females selected total individuals exhibiting visible oocytes ovaries females classified reproductive phase sub phase early developing developing spawning capable actively spawning six histological sections taken anterior middle posterior regions left right ovary lobes individual digital image processing axiovision image proplus programs used estimate oocyte density per unit area different development stages contingency tables used analyze oocyte distribution frequencies regions lobe lobes ovary supported pearson chi test goodness fit replicated test confirm distribution heterogeneity oocyte stage distribution homogeneous almost females regardless ovary lobe left ovary lobe oocyte distribution uniform three regions sampled regardless female phase sub phase right ovary lobe oocyte frequencies similarly uniform phase sub phases nevertheless phase heterogeneity observed tertiary vitellogenesis vtg oocytes especially samples middle posterior regions lobe females sub phase normally used estimate batch fecundity fish maximus shown asynchronous oocyte development batch spawning given homogeneous oocyte distribution pattern within ovary lobes females sub phase systematization required gonad histological sampling protocol estimate species batch fecundity nevertheless due heterogeneous vtg oocytes distribution right ovary lobe females phase best systematically take sections region left ovary lobe conducting study encompassing species reproductive aspects
introduction patients psoriasis increased risk cardiovascular disease data atopic dermatitis less clear cut however well established erectile dysfunction serve risk marker coronary disease aim investigate incidence prevalence risk men psoriasis methods sample included danish men least years old patients psoriasis determined disease severity based use systemic therapy performed cross sectional study january using logistic regression estimate prevalence odds ratio moreover cohort study design patients followed january december cox regression models used estimate adjusted hazard ratios new onset models adjusted potential confounding factors including age socioeconomic status health care consumption smoking alcohol abuse diabetes cholesterol lowering drug use main outcome measures outcome initiation pharmacotherapy used treatment results sample consisted danish men age range years adult mild severe psoriasis mild severe respectively mean ages sds years general population patients patients psoriasis respectively prevalences general population patients patients psoriasis respectively adjusted odds ratios logistic regression decreased patients increased psoriasis adjusted odds ratios mild severe respectively psoriasis adjusted hazard ratios cox regression psoriasis risk increased men mild severe significantly increased men mild psoriasis severe psoriasis conclusion found increased prevalence risk men psoriasis whereas risk comparable even slightly lower general population men copyright international society sexual medicine published elsevier inc rights reserved
classic contemporary research person perception demonstrated paramount importance interpersonal warmth recent research embodied cognition shown feelings social warmth coldness induced experiences physical warmth coldness vice versa show people tend self regulate feelings social warmth applications physical warmth apparently without explicit awareness study higher scores measure chronic loneliness social coldness associated increased tendency take warm baths showers study physical coldness manipulation significantly increased feelings loneliness study needs social affiliation emotion regulation triggered recall past rejection experience subsequently eliminated interpolated physical warmth experience study provided evidence people explicitly aware relationship physical social warmth coldness consider target person often bathes lonelier one else equal together findings suggest physical social warmth extent substitutable daily life substitution reflects unconscious self regulatory mechanism
borderline personality disorder bpd characterized severe persistent impairments interpersonal functioning given complexity social interactions studying interactive behavior bpd patients challenging one way implement tight experimental control realistic externally valid settings use game theoretical experiments review discusses findings economic exchange studies bpd background game theoretical literature bpd patients seem derive utility mutual cooperation others appear forgive partner unfairness pursuing strategy negative reciprocity bpd patients seem act mostly rationally self interest grim trigger strategy resembles theoretical ideal rational self interested agent homo economicus finally summarize research findings economics clinical psychiatry may mutually enriching propose new research ideas fascinating field elsevier ltd rights reserved
rationale primary angiitis central nervous system pacns inflammatory disease involving cerebrovascular parenchymal solitary tumor like mass lesion pacns tlml pacns frequently misdiagnosed neoplastic inflammatory diseases however seizure syndrome first manifestation tlml pacns rarely reported patient concerns report cases seizure syndrome first sign presented prior diagnosis tlml pacns brain biopsy diagnoses mass lesion white gray matters detected magnetic resonance imaging pathology leptomeningeal lesion biopsy observed transmural inflammation artery lymphocyte infiltration patients diagnosed pacns epileptic seizure biopsy electroencephalogram interventions patients treated glucocorticoid pulse therapy days subsequently oral prednisone continued combination immunosuppressant outcomes luckily two patients improved treatment mild cognitive impairment remained without adverse event lessons patient mass lesion cns similar tumor presented seizure headache cerebrovascular events without risk factors stroke tumor considered feasible disease tlml pacns
fact security facilities within system closely coupled security facilities systems unconnected results isolated protection structure systems gives rise serious challenge system security integrations system controls also need diversified services flexible extensions network security asks considerations contributions perspective software engineering process designing constructing security systems based essence virtualization technique idea software defined networks paper propose novel software defined security architecture systems abstracting traditional security facilities techniques proposed security architecture provides new simple effective programmable framework security operations security controls decoupled thereby reduces software module sizes decreases intensity software developments improves security extensibility systems
objective aim study examine prevalence adhd psychiatric comorbidity including substance use incarcerated women method cross sectional study consisting two parts screening using adhd self rating scale asrs diagnostic assessment using structured interview results sample incarcerated women screened underwent diagnostic assessment twenty nine percent women met diagnostic statistical manual mental disorders diagnostic criteria adult adhd diagnostic assessment forty four women misuse alcohol misuse narcotics year prior incarceration asrs showed sensitivity specificity conclusion prevalence rate adhd incarcerated women high comparable male offenders illicit stimulant use antisocial personality disorder significantly common women adhd asrs useful screener population
flickrk dataset become standard benchmark sentence based image description paper presents flickrk entities augments captions flickrk coreference chains linking mentions entities across different captions image associating manually annotated bounding boxes annotations essential continued progress automatic image description grounded language understanding enable define new benchmark localization textual entity mentions image present strong baseline task combines image text embedding detectors common objects color classifier bias towards selecting larger objects baseline rivals accuracy complex state art models show gains easily parlayed improvements tasks image sentence retrieval thus underlining limitations current methods need research
thickness dependence one parameter based fracture toughness well recognized widely studied however still challenge predict fracture structures curved cracks fracture toughness data obtained standard thickness cracked specimens complicated three dimensional stress fields near crack front play vital role fracture strength materials based systematical numerical study stress fields near crack tip quarter elliptic corner cracks comparison ideal thickness cracks equivalent thickness conception curved cracks proposed viewpoint plane constraint semi analytical solution equivalent thickness corner cracks obtained evaluated equivalent thickness fracture toughness corner cracked specimens predicted efficiently plane strain toughness value material obtained standard thickness specimen elsevier ltd rights reserved
surface reflection based method measuring heart rate saturation introduced one significant advantage legacy methods lends use special applications person mobility prime importance miner work excluding use traditional clips complete atmega based microcontroller platform described performing computational tasks signal processing wireless transmission next section remarks provided regarding basic signal processing rules beginning raw voltage samples converted optical signals acquisition storage smoothing chapter ends practical remarks demonstrating exponential dependence minimum measurable heart rate readout resolution different sampling frequencies different cases averaging depth bits following section devoted strictly heart rate hemoglobin oxygenation saturation measurement use presented platform referenced measurements obtained stationary certified pulsoxymeter
singular value decomposition svd based ultrasound blood flow clutter filters recently demonstrated substantial improvement clutter rejection ultrafast plane wave microvessel imaging become commonly used clutter filtering method many novel ultrafast imaging applications functional ultrasound super resolution imaging present however computational burden svd remains major hurdle practical implementation clinical translation method address challenge study present two blood flow clutter filtering methods based randomized svd rsvd randomized spatial downsampling accelerate svd clutter filtering minimal compromise clutter filter performance rsvd accelerates svd computation approximating largest singular values random downsampling accelerates full svd rsvd decomposing original large data matrix small matrices processed parallel vitro blood flow phantom study presence heavy tissue clutter showed significantly improved computational performance using proposed methods minimal deterioration clutter filter performance less reduction blood clutter ratio less increase flow mean squared error less increase standard deviation vessel blood flow signal less increase tissue clutter velocity full svd rsvd downsampling factor less maximum acceleration threefold randomized spatial downsampling approximately another threefold rsvd vivo rabbit kidney perfusion study showed rsvd provided comparable performance full svd clutter rejection vivo maximum difference blood clutter ratio less random downsampling provided artifact free perfusion imaging results combined full svd rsvd blood clutter ratio still downsampling factor also demonstrated realtime microvessel imaging feasibility similar processing time combining rsvd random downsampling findings methods presented paper may greatly facilitate new area ultrafast microvessel imaging research
objectives describe longitudinal relationships metabolic syndrome mets cognitive decline functional disability sample older non institutionalized men methods data italian cohorts finland italy netherlands elderly fine study used global cognitive function functional disability defined limitations mobility basic adls instrumental activities daily living iadls screened mets defined according ncep atp iii criteria results study sample consisted men baseline age years baseline mets prospectively associated greater year cognitive functional decline adls iadls multiple adjustment including age education marital status apoe epsilon allele cerebrovascular disease initial cognitive depressive status mets predicted cognitive decline risk iadls adls disability interestingly associations attributable individual altered components mets sum incident disability adls iadls explained parallel decline cognitive function conclusions mets entity associated accelerated cognitive functional decline population based sample old men elsevier ireland ltd rights reserved
past research shown exposure aggression associated negative responses toward others also toward self present research argue aggressive priming influences content thoughts primary cognition also influence people think thoughts secondary meta cognition circumstances two experiments showed effect direction thoughts positive negative self evaluation greater receiving aggressive control priming induction among participants listing negative self attributes aggressive control prime condition reported negative self attitudes however among participants listing positive traits aggressive neutral primes led favorable self attitudes reversing traditional effects aggression self evaluation
two person neuroscience perspective understanding human social cognition interaction involves designing immersive social interaction experiments well simultaneously recording brain activity two subjects process termed hyperscanning using newly developed imaging techniques interbrain connectivity hyperlink various types social interaction revealed functional near infrared spectroscopy fnirs hyperscanning provides naturalistic environment experimental paradigms social interaction recently drawn much attention however fnirs hyperscanning studies computed hyperlinks using sensor data directly ignoring fact sensor level signals contain confounding noises may lead loss sensitivity specificity hyperlink analysis study basis independent component analysis ica source level analysis framework proposed investigate hyperlinks fnirs two person neuroscience study performance five widely used ica algorithms extracting sources interaction compared simulative datasets increased sensitivity specificity hyperlink analysis proposed method demonstrated simulative real two person experiments society photo optical instrumentation engineers spie
hypothesis retrieval correct source memory cues leading correct source attribution increases confidence whereas retrieval incorrect source memory cues leading source misattribution decreases confidence tested four predictions derived hypothesis confidence higher correct incorrect source attribution except source cues retrieved source misattributions inferred retrieval incorrect source cues rated low confidence number source cues retrieved either correct incorrect affect confidence source attributions test predictions participants read two narratives two witnesses bank robbery customer teller participants completed source monitoring test four alternatives customer teller neither rated confidence source attribution results supported first three predictions also suggested number correct source monitoring cues retrieved play role monitoring accuracy source attributions attributions made recovery incorrect source cues could tagged dubious uncertain thus leading lowered confidence irrespective number incorrect source cues whether another correct source cue also recovered research potential applications eyewitness memory shows confidence indicator accuracy source attribution
objectives primary objective describe prevalence osteoporosis diagnosis nursing home residents nhrs secondary objectives included assessment pharmacologic therapies risk fracture nhrs well differentiating clinical characteristics treated versus untreated male female nhr finally sought evaluate persistence compliance rates nhrs treated determine prevalence severe renal impairment nhrs treated bisphosphonate design retrospective cohort analysis setting participants nhrs minimum data set mds record omnicare senior health outcomes osho data repository time period october september measurements patient considered diagnosis mds item indicated nhr mds record contained icd codes expanded definition diagnosis explored nhr previous fracture mds items also considered pharmacologic therapies extracted pharmacy claims data included alendronate calcitonin salmon denosumab ibandronate raloxifene risedronate teriparatide using mds items cognitive impairment brief instrument mental status cognitive performance scale functional impairment composite activities daily living assessed using mds prescription claims data high risk fracture least following age years female gender previous fracture history falls use bisphosphonate assessed persistence indicated continuous use therapy without gap days compliance calculated using medication possession ratio creatinine clearance clcr calculated using modified cockcroft gault equation results prevalence nhrs using expanded definition prevalence increased among nhrs mean age female gastroesophageal reflux disease ulcer per definition high risk fracture based older age female gender prior fracture fall history use bisphosphonates nhrs met criteria additionally hip fracture fracture overall nhrs received active treatment one third received pharmacologic therapy received oral bisphosphonate history hip fracture similar treatment rates without whereas history fracture likely treated without two thirds residents moderate severe cognitive impairment residents less likely receive therapy without persistence pharmacologic therapy nhr full year pharmacy data higher raloxifene calcitonin salmon bisphosphonates similar nhrs received teriparatide denosumab lower nhrs received bisphosphonates creatinine clearance data clcr lower min conclusion recognized prevalence nhrs using mds records low consistent previous reports among documented diagnosis approximately nhrs high risk fracture one third treated active pharmacologic therapy treated persistence compliance suboptimal higher oral therapies half nhrs treated bisphosphonates clcr less min suggesting alternative forms therapy considered reasons opportunity exists improve care medication use residents high risk fracture amda society post acute long term care medicine
paper describes design two stage operational amplifier using three structures calculation various parameters three basic designs include cmos hybrid cmos dtmos full dtmos operate power supply technology paper simulation curves computed different characteristics gain icmr cmrr simulation carried pspice tool three design application specific basic cmos based stage amp provides high open loop voltage gain rail rail output swing first proposed design hybrid cmos dtmos provides additional gain increased cmrr higher phase margin second proposed design full dtmos based stage amp used low power applications dtmos best alternative implementation low power circuits
paper aims develop green building meta model representative passively designed high rise residential building hong kong modelling experiments conducted energyplus explore monte carlo regression approach intends interpret relationship input parameters output indices generic building model provide reliable building performance predictions input parameters selected different passive design strategies including building layout envelop thermophysics building geometry infiltration air tightness output indices corresponding indoor environmental indices daylight natural ventilation thermal comfort fulfil current green building requirements variation sampling size application response transformation bootstrap method well different statistical regression models tested validated separate modelling datasets sampling size per regression coefficient determined variation sensitivity coefficients coefficients determination prediction uncertainties rank transformation responses calibrate sensitivity coefficients non linear model considering variation obtained sufficient bootstrapping replications furthermore acquired meta model mars multivariate adaptive regression splines proved better model fitting predicting performances research accurately identify important architectural design factors make robust building performance predictions associated green building assessment sensitivity analysis results obtained meta models improve efficiency future optimization studies pruning problem space shorten computation time elsevier ltd rights reserved
background studies comparing efficacy dawn simulation conventional bright light treatment seasonal affective disorder parallel groups yielded conflicting results crossover study investigated treatment outcomes long term treatment preference methods forty winter depressives treated week bright light min shortly awakening dawn simulation gradually increasing light last min sleep achieving alarm beep dawn simulator placed closer open eyes min depression level self rated using sigh sad results depression scores reduced similarly following bright light dawn simulation medians respectively efficacy ratio preference also similar among preferred bright light common reason perceived bright light effective effective subgroup tended severe depression ease use among preferred dawn simulator reasons natural action device compactness lime saving cases bright light caused eyestrain limitations overhead naturalistic light dawn simulation self rating depression conclusions dawn simulation similarly effective bright light treatment winter depression patients severe depression tended report greater improvement bright light cases would outweigh non clinical advantages dawn simulation elsevier rights reserved
one application ambient intelligence ami supports people daily activities smart home become popular topic research past years smart home support inhabitant variety ways watching potential risks detecting abnormality adapting home environmental conditions inducing behavioural change often requires smart home recognise behaviours inhabitant paper introduce method accurately recognise inhabitant behaviours includes segmentation sensor stream identification behaviours demonstrate algorithm sensor data real smart homes
early onset drug use associated increased risk developing substance use disorders relatively little known correlates early drug use among adults receiving treatment retrospective analysis randomized study contingency management treatment compared cocaine dependent patients reported initial cocaine use age younger began using age patients early onset cocaine use legal psychiatric problems initiated cocaine use later patients early onset cocaine use also dropped treatment sooner achieved less sustained abstinence began using older ages interaction age first use treatment condition significant early onset cocaine use associated persistent psychosocial problems overall poor response treatment however contingency management efficacious improving outcomes early onset cocaine users elsevier inc rights reserved
short wavelength blue light caffeine studied mood enhancing effects humans ability blue light increase alertness mood cognitive function via non image forming neuropathways suggested non pharmacological countermeasure depression across range occupational settings experimental study compared blue light caffeine aimed test effects blue light placebo blu white light caffeine caf blue light caffeine bcaf white light placebo pla mood randomised controlled crossover design study used convenience population healthy volunteers participants rated mood swedish core affect scales scas prior experimental condition assess dimensions valence activation significant main effect light combination blue light caffeine clear positive effects core effects ranging global mood benefits combination blue light caffeine investigated across range applications due observed effects dimensions arousal valence pleasant activation
use computer vision techniques post harvest processing agricultural products increased considerably recent years due non destructive rapid monitoring abilities image processing combined pattern recognition applied fruit sorting classification study bag feature bof model used classification sweet bitter almond varieties harris harris laplace hessian hessian laplace maximally stable extremal regions mser keypoint detectors along scale invariant feature transform sift descriptor used bof model means clustering method applied building codebook keypoint descriptors performance classifiers nearest neighbour linear chi square support vector machine svm chi svm respectively compared using classification results model observed chi svm classifier outperformed svm classifiers using bof model possible detect classify sweet bitter varieties high overall accuracy iagre published elsevier ltd rights reserved
capacity learn remember surely evolved help animals solve problems quest reproduce survive humans assume metacognitive processes also evolved know trust remember high confidence memories low confidence however latter feature questioned researchers finding high correlation confidence accuracy reports memory others finding little correlation two experiments report recognition memory paradigm using materials categorised lists permits study positive correlations zero correlations negative correlations confidence accuracy within procedure subjects study words semantic categories five items frequently produced norms omitted list later subjects given old new recognition test made confidence ratings judgements although correlation confidence accuracy studied items generally positive correlation five omitted items negative methods analysis pinpoint similarity lures targets creating inversions confidence accuracy memory argue confidence generally useful indicant accuracy reports memory certain environmental circumstances even adaptive processes foster illusions memory thus understanding memory illusions similar understanding perceptual illusions processes usually adaptive awry certain circumstances
generally writing medicine ancient egypt historians adopt approach rather benevolent critical giving practice merits never reading without prejudice famous twelve papyri one less pronounce condemnatory sentence end medicine looks like patchwork ignorance superstition magic believes pair grains knowledge however rescue surgical practice useful sometimes efficient quite necessary centuries war slavery permanent abuse weak poor people high political rulers priests
present novel thermal energy harvesting system using triboelectric effect recently intensive research efforts energy harvesting using triboelectric effect produce surprising amount electric power compared piezoelectric materials rubbing touching electric charge contact separation two different materials together numerous studies shown possibility attractive alternative good transparency flexibility low cost abilities use wearable device smart phone applications markets however application limited vibration source produce sustained oscillation maintaining contact separation states repeatedly triboelectric effect thus attempt toward thermal energy source proposed approach convert thermal energy electricity pairing triboelectric effect active ferromagnetic materials objective research develop new manufacturing process design fabrication testing magneto thermo triboelectric generator mttg results obtained approach show mttg devices feasible power energy conversion capability thermal energy sources tunable design device efficient thermal capture wide range operation temperature waste heat
paper focuses identification nonlinear vibration system power transformers hammerstein model used identify system electrical inputs vibration transformer tank output nonlinear property system modelled using fourier neural network consisting nonlinear element linear dynamic block order weights network determined based lipschitz criterion back propagation algorithm system identification method tested several power transformers promising results predicting transformer vibration extracting system parameters presented discussed
online social networks become pervasive people lives play crucial role design development processes applications moment gap exists standard networking programming support social network based programming large according software engineering principles genericity polymorphism drawback made evident applications built top multiple social networks user centered vision kept indeed heterogeneity social networks allow produce software suitable abstraction paper cover gap defining implementing model aimed generalizing concepts actions relationships existing social networks effectiveness approach shown two case studies elsevier inc rights reserved
kundu eckhaus equation derivative nonlinear schrodinger equation describe various physical processes nonlinear optics plasma physics fluid mechanics magneto hydrodynamic equation presence hall effect thus closed form solutions equations important realize obscurity phenomena modified simple equation mse method highly effective competent mathematical tool examine closed form wave solutions nonlinear evolution equations nlees arising mathematical physics applied mathematics engineering article mse method suggested executed construct closed form wave solutions mentioned equations involving parameters parameters receive special values impressive solitary wave solutions derived exact solutions
power system harmonics estimated properly maintenance power quality need development accurate computationally efficient estimation technique context paper presents harmonics estimation technique using variable leaky least mean square algorithm proposed method drifting parameters avoided using leak adjustment method improve rate convergence step size also adapted method real time power system also imitated using different cases simulation enables superiority proposed method existing techniques studies made experimental data processed arduino due microcontroller also support superiority elsevier ltd rights reserved
internet shopping optimization problem arises customer aims purchase list goods set web stores minimum total cost problem hard strong sense interested solving internet shopping optimization problem additional delivery costs associated web stores goods bought interest extend model including price discounts goods aim paper present set optimization algorithms solve problem purpose find compromise solution computational time results close optimum value performance set algorithms evaluated simulations using real world data collected web stores quality results provided set algorithms compared optimal solutions small size instances problem optimization algorithms also evaluated regarding scalability size instances increases set results revealed algorithms able compute good quality solutions close optimum reasonable time good scalability demonstrating practicability
school shootings tear fabric society wake school shooting parents pediatricians policymakers politicians public search cause shooting single cause causes school shootings extremely complex sandy hook elementary school rampage shooting newtown connecticut wrote report national science foundation known known youth violence article summarizes updates report distinguishing violent behavior aggressive behavior describe prevalence gun violence united states age related risks violence delineate important differences violence context rare rampage school shootings much common urban street violence acts violence influenced multiple factors often acting together summarize evidence major risk factors protective factors youth violence highlighting individual contextual factors often interact consider new quantitative data mining procedures used predict youth violence perpetrated groups individuals recognizing critical issues privacy ethical concerns arise prediction violence also discuss implications current evidence reducing youth violence offer suggestions future research conclude arguing prevention youth violence national priority
irritable bowel syndrome diarrhea ibs common chronic functional gastrointestinal disorder symptoms distressing patients often result substantially impaired quality life review focuses providing clinicians information practical evidence based treatment ibs current therapies commonly used treatment ibs including pharmacologic nonpharmacologic interventions briefly reviewed followed discussion emergent pharmacologic treatments rifaximin eluxadoline medical foods ibgard enteragam given lack standard treatment algorithm ibs emergence new pharmacologic therapies treatment needs tailored individual patient take account severity disease context latter part manuscript examines treatments ibs used clinical practice presenting three patient case scenarios varying degrees ibs severity case patient medical history clinical presentation related rome foundation multidimensional clinical profile mdcp potential treatment options current emergent therapies reviewed interplay gastrointestinal symptoms psychosocial impact well importance patient centered approach therapy discussed consideration given potential need combination therapies emergent treatments could fit treatment pathway mild moderate severe cases ibs clinical practice
article deals design four channel device serving photoplethysmographic measurements described main parts device analog digital signal processing part microcontroller controlled led drivers work includes description digital data processing algorithm presented design graphical user interface device functionality verification use device medical purposes outlined preliminary measurements data analysis performed within analysis correlated second derivative pulse wave contour age measured subjects
competitiveness second generation bioethanol biotechnological process requires effective quantitative control biochemical reactions study potential isothermal calorimetry technique measure heat kinetics non homogeneous substrate enzymatic hydrolysis intended using technique optimum temperature enzymes used lignocellulosic molecules hydrolysis determined thus amount substrate enzyme ratio highlighted important parameter hydrolysis yield furthermore new enzymes cocktail efficiency consisting mix cellulases cellobiose dehydrogenase cdh qualified technique results showed cocktail allowed production high amount gluconic acid could improve attractiveness second generation biofuels set experiments hydrolysis heat wheat straw derived meaningful value gram reducing sugars product calculated isothermal measurements used determine kinetic constants cellulases cdh mix wheat straw results showed enzyme cocktail optimal rate degrees range temperatures tested degrees
objective unsafe abortions account nearly one third maternal deaths among young people women induced abortion usually literate less years old usually undergraduates unintended pregnancies many pregnancies could prevented contraception aim study determine correlates uptake emergency contraception among university students methods cross sectional study conducted among sexually active never married female university students self administered questionnaire used assess knowledge perception practice emergency contraception multivariate logistic regression used identify predictors emergency contraception results majority participants aware emergency contraception good knowledge perception effective easy use main sources information emergency contraception friends media participants unprotected sex preceding six months ever used emergency contraception main sources commodities sexual partners medicine stores uptake emergency contraception predicted years aor rural dwelling aor perceptions effective aor easy use aor conclusion use contraception among sexually active female nigerian university students predicted perception effectiveness ease use sexual reproductive health programmes focus improving knowledge addressing misconception order improve perception emergency contraception elsevier rights reserved
article reviews recent advances study european court justice ecj political impact european member state levels new quantitative well qualitative analyses show great empirical precision member state preferences guide court article summarises findings argues greater attention needs given constitutionalisation law order fully capture political impact ecj jurisprudence even european judges less activist often assumed individual decisions restrained face member state opposition incrementally case law evolves highly expansive fashion exercising caution regarding unrealistic expectations quasi deterministic judicial law making found court constitutionalised jurisprudence impacts heavily european member state policy making
study question parity timing menarche associated premature early natural menopause summary answer early menarche years risk factor premature menopause final menstrual period fmp years early menopause fmp years risk amplified nulliparous women known already women either premature early menopause face increased risk chronic conditions later life early death findings studies suggest early menarche nulliparity associated early menopause however overall evidence mixed much evidence direct relationship hampered lack comparability across studies failure adjust confounding factors inadequate statistical power study design size duration pooled study comprises postmenopausal women nine observational studies scandinavia australia japan contribute international collaboration life course approach reproductive health chronic disease events interlace participants materials setting methods age menarche categorized years parity categorized children one child two children exposures interest age fmp confirmed least months cessation menses result intervention surgical menopause due bilateral oophorectomy hysterectomy categorized premature menopause fmp age early menopause fmp years years years years years used multivariate multinomial logistic regression models estimate relative risk ratio rrr associations menarche parity age fmp adjusting within study correlation main results role chance median age fmp years interquartile range years women experiencing premature menopause early menopause women early menarche years two children limitations reasons caution studies except birth cohorts relied retrospectively reported age menarche may led degree recall bias wider implications findings findings support early monitoring women early menarche especially children preventive health interventions aimed mitigating risk adverse health outcomes associated early menopause study
exploratory work concerned generation natural language descriptions used video retrieval applications step ahead keyword based tagging captures relations keywords associated videos firstly prepare hand annotations consisting descriptions video segments crafted trec video dataset analysis data presents insights human interests video contents secondly develop framework creating smooth coherent description video streams builds conventional image processing techniques extract high level features individual video frames natural language description produced based high level features although feature extraction processes erroneous various levels explore approaches putting together produce coherent smooth well phrased description incorporating spatial temporal information evaluation made calculating rouge scores human annotated machine generated descriptions introduce task based evaluation human subjects provides qualitative evaluation generated descriptions
ablation strategies targeting areas complex fractionated atrial electrograms successful treatment atrial fibrillation fractionation atrial electrograms may multiple causes pathologic nonpathologic origin order gain insight definitions used determining areas fractionation literature search performed using systematic approach pubmed search studies describing fractionation human atrial electrophysiologic measurements resulted articles screened new definitions fractionation studies remaining screening described different visual definitions fractionation automated complex fractionated atrial electrogram detection programs new parameters measuring fractionation five different definitions continuous electrical activity presented electrode properties often described endocardial bipolar recordings recent studies used electrode diameters ranging interelectrode distance summary uniform definition recording method used measuring fractionation cardiac atrial electrograms different electrophysiologic causes fractionation influence recording device properties fractionation complicate identification true pathologic inhomogeneous conduction first step discrimination origins fractionation may accomplished relating electrogram morphology spatial patterns activation revisiting ablation areas fractionated electrograms need determine correct method identifying pathologic fractionation
paper presents robust control method combining conventional proportional integral derivative pid scheme sliding mode fuzzy control scheme second order non linear system uncertainties system dynamics goal proposed scheme force response uncertain plant follow nominal model first phase design approach obtain nominal pid controller nominal plant model poor performance sole pid scheme uncertain non linear system motivates proposal technique discussed compensate deficiencies unit step response uncertain system fuzzy compensation scheme based sliding mode control smc proposed pid loop augmented proposed approach shown performance proposed scheme better sole pid based control system proposed technique response uncertain system converges nominal system admissible controller outputs furthermore simulation results show proposed method produces consistent results even noisy measurements
forced oscillation technique fot measures respiratory impedance noninvasive way obtain mechanical properties respiratory system respiratory impedance zrs defined frequency dependent ratio pressure flow airway opening major problem measuring zrs low frequencies spontaneously breathing patients disturbance generated patients breathing method presented aims eliminating breathing disturbances low frequent fot measurements applying combination amplitude phase modulated signal models regularized least squares method validated simulations using breathing measurements estimates zrs low error obtained addition method applied measurements performed group healthy subjects results obtained used diagnostic purposes studies parametric modeling zrs low frequencies
background chronic angina common patients diabetes mellitus poor glucose control ranolazine treats chronic angina improves glucose control objectives study sought examine ranolazine antianginal effect relation glucose control methods authors performed secondary analysis river pci ranolazine patients incomplete revascularization percutaneous coronary intervention trial clinical trial patients chronic angina incomplete revascularization following percutaneous coronary intervention randomized ranolazine versus placebo mixed effects models used compare effects ranolazine versus placebo glycosylated hemoglobin hba month follow interaction baseline hba ranolazine effect seattle angina questionnaire angina frequency months tested results overall patients baseline compared placebo ranolazine significantly decreased hba adjusted mean difference baseline months respectively patients months respectively non patients compared placebo ranolazine significantly reduced seattle angina questionnaire angina frequency months among patients months reductions angina frequency numerically greater among patients baseline hba hba interaction conclusions patients chronic angina incomplete revascularization percutaneous coronary intervention ranolazine effect glucose control angina months proportionate baseline hba effect angina dissipated months american college cardiology foundation
paper presents concurrent garbage collection method functional programs running multicore processor concurrent extension bitmap marking non moving collector yuasa snapshot beginning strategy collector unobtrusive sense doligez leroy gonthier collector collector stop mutator thread force synchronize globally critical sections mutator collector code enqueue dequeue allocation segment global segment list write barrier code push object pointer onto collector stack data structures implemented standard lock free data structures achieves efficient allocation unobtrusive collection multicore system proposed method implemented sml full scale standard compiler supporting multiple native threads multicore cpus benchmark tests show drastically short pause time reasonably low overhead compared sequential bitmap marking collector
article ags quantum dots qds prepared facile aqueous synthesis method using thiourea new sulfur precursor based electrostatic interactions fluorouracil combined aptamer antigen fabricate aptamer complex surface prepared ags qds modified polyethylenimine followed combination aptamer complex form qds aptamer hybrids combination ags qds aptamer complex near infrared nir photoluminescence qds peaked markedly reduced excitation attributed photo induced electron transfer qds however addition induced obvious nir recovery ascribed strong binding affinity aptamer separation aptamer complex surface qds hence ags qds aptamer hybrids developed novel nir turn probe concentration range good linear relationship nir intensities ags qds log low limit detection experimental results revealed highly selective sensitive nir responses probe potential interferences real human body fluids probe also exhibited superior analytical performance together high detection recoveries
corrosion behaviour austenitic stainless steel simulated oilfield produced water similar degrees investigated electrochemical properties stainless steel assessed experimentally employing potentiodynamic polarisation electrochemical impedance spectroscopy measurements corrosion mechanism stainless steel simulated oilfield produced water along appropriate modelling equivalent electrical circuits deducted results showed corrosion rate reduced time behaviour indicate protection stainless steel instead pits formed surface specimens evolution continued time
objective advent anaplastic lymphoma kinase alk inhibitor treatment alk positive advanced non small cell lung cancer nsclc patients become effective drug costs still major concern study aimed estimate budget impact crizotinib versus standard therapies thai advanced nsclc patients alk rearrangement methods budget impact model developed estimate net budget impact crizotinib compared crizotinib considering payer perspective three year period costs included drugs alk testing fish adverse event treatment administration monitoring best supportive care data costs population database thailand costs presented year univariate sensitivity analysis performed investigate robustness findings results total net budget impact crizotinib three years thb usd thb usd thb usd respectively considering patients receiving crizotinib expenditure increased thb usd thb usd thb usd per patient per month main driven costs cost alk testing drugs conclusion despite treatment value alk positive patients crizotinib affordable thai patients within upper middle high economic status availability patients current payment models limited
irritable bowel syndrome ibs functional bowel disease complicated etiopathogenesis often characterized gastrointestinal motility disorder high visceral sensitivity ibs comprehensive multi systemic disorder interaction multiple factors mental stress intestinal function flora heredity resulting disease existence common mechanism underlying aforementioned factors currently unknown lack therapies comprehensively address disease symptoms including abdominal pain diarrhea limitation current ibs management current review explored role scf kit receptor ligand system ibs scf kit system constitutes classical ligand receptor tyrosine kinase signaling system mediates inflammation smooth muscle contraction additionally provides trophic support neural crest derived cell types including enteric nervous system mast cells regulation scf kit interstitial cells cajal icc suggest may play key role aberrant intestinal dynamics high visceral sensitivity observed ibs role scf kit system intestinal motility inflammation nerve growth reported available biomedical evidence pathogenesis ibs concluded scf kit system potential therapeutic target rational drug design treatment ibs
random number generators essential modern cryptography security cryptographic scheme achieved assumption system uses ideal random numbers produce sensitive security parameters encryption keys initial vectors weakness random number generator makes entire cryptographic system insecure particular lack entropy sources leads predictable output random bits secret information guessed malicious attackers therefore important collect sufficient entropy physical noise sources paper consider graphics processing units gpus entropy source race conditions parallel computations gpu harvest sufficient entropy cryptography using entropy estimations nist amount entropy estimated compared physical sources
micro nano positioning technologies attractive decades various applications industrial scientific fields actuators employed technologies typically smart material actuators possess inherent hysteresis may cause systems behave unexpectedly periodic reference tracking capability fundamental apparatuses scanning probe microscope employs smart material actuators generate periodic scanning motion however traditional controller pid method guarantee accurate fast periodic scanning motion tackle problem conduct practical implementation digital devices paper proposes novel control method named discrete extended unparallel prandtl ishlinskii model based internal model eupi control approach tackle modeling uncertainties robust eupi control approach investigated associated sufficient stabilizing conditions derived advantages proposed controller designed represented discrete form thus practical digital devices implementation extended unparallel prandtl ishlinskii model precisely represent forward inverse complex hysteretic characteristics thus reduce modeling uncertainties benefits controllers design addition internal model principle based control module utilized natural oscillator tackling periodic references tracking problem proposed controller verified comparative experiments piezoelectric actuator platform convincing results achieved
metamaterial based electromagnetic wave absorbers may provide perfect absorption significant range electromagnetic spectrum perfect broadband absorption metamaterial absorbers play important role stealth technology paper design simulation measurements novel band ghz metamaterial broadband absorber presented absorber operating middle microwave band obtained selecting differently sized unit cells placing resonant frequencies close paper presents two absorbers consist different number unit cells first absorber unit cells koh unit cells koh observed simulation results good agreement measurements measurement bandwidth absorption level ghz koh ghz koh highest absorption levels planar metamaterial absorbers band absorption mechanism broadband metamaterial absorber also investigated using electric magnetic field distribution results study promising stealth applications absorbing elements band radars elsevier gmbh rights reserved
paper presents development improved frequency compensation method two stage operational amplifier indirect feedback current beneficial large capacitive load applications describes case nulling resistor added output way residing outside outer feedback loop amplifier compared case nulling resistor placed outside inner frequency compensation loop inside outer feedback loop amplifier driving capability substantially improved capacitive load improve stability gaining degree extra phase margin prototype implemented stmicroelectronics cmos technology simulated cadence virtuoso simulations room temperature show improvement unity gain frequency mhz ghz extra phase margin gain degree simulation temperature effect showed phase margin gain remains temperature range degrees
increasing amount volatile renewable electrical energy balancing demand supply becomes demanding demand response one emerging tools new landscape targeting service sector buildings investigated tariff driven demand response model means shave electrical peak loads thus reducing grid balancing energy paper presented software framework load shifting uses tariff signal electric energy minimization target framework used top existing building management system shift heat generation towards low tariff times well simulate load shifting different buildings heat pumps storage configurations modular architecture allows easily replace optimizers weather data providers building management system adapters results show even current tou tariff system cost savings reduction energy consumption achieved sub mpc modifiedmpcoptimizer could reduce computing times factor slightly affecting quality optimization increasing amount volatile renewable electrical energy balancing demand supply becomes demanding demand response one emerging tools new landscape targeting service sector buildings investigated tariff driven demand response model means shave electrical peak loads thus reducing grid balancing energy paper presented software framework load shifting uses tariff signal electric energy minimization target framework used top existing building management system shift heat generation towards low tariff times well simulate load shifting different buildings heat pumps storage configurations modular architecture allows easily replace optimizers weather data providers building management system adapters results show even current tou tariff system cost savings reduction energy consumption achieved sub mpc modified mpc optimizer could reduce computing times factor slightly affecting quality optimization
overview paper describes study protocol used evaluate resilient empowered active living diabetes real diabetes intervention reports baseline characteristics recruited participants real diabetes activity based intervention designed address needs young adults diagnosed type type diabetes low socioeconomic status racial ethnic minority backgrounds real intervention incorporates tailored delivery seven content modules addressing various dimensions health well relate diabetes delivered licensed occupational therapist methods pilot randomized controlled trial participants assigned real diabetes intervention attention control condition study primary recruitment strategies included person recruitment diabetes clinics mass mailings clinic patients social media advertising data collection includes baseline month assessments primary outcomes secondary outcomes hypothesized mediators intervention effects well ongoing process evaluation assessment ensure study protocol adherence intervention fidelity results baseline participants female latino average years old average hbal majority participants demonstrated clinically significant diabetes distress reported symptoms consistent major depressive disorder compared participants participants lower diabetes related self efficacy problem solving skills compared participants recruited clinics participants recruited strategies greater diabetes knowledge weaker medication adherence discussion participants real study demonstrate clinically significant medical psychosocial needs elsevier inc rights reserved
paper presents synergistic effects bipolar operational amplifier radiation effects studied neutron beam gamma ray mixed neutron gamma ray environments characterateristics synergistic effects studied comparison different experiment results results show bipolar operational amplifier exhibited significant synergistic effects mixed neutron gamma irradiation bipolar transistor identified radiation sensitive unit operational amplifier paper series simulations performed bipolar transistors different radiation environments theoretical simulation geometric model calculations based medici toolkit built study radiation effects bipolar components effect mixed neutron gamma irradiation simulated based understanding underlying mechanisms radiation effects bipolar transistors simulated results agree well experimental data results experiments simulation indicate radiation effects bipolar devices subjected mixed neutron gamma environments simple combination total ionizing dose tid effects displacement damage data suggests tid effect could enhance displacement damage synergistic effect neglected complex radiation environments published elsevier
atrial fibrillation common often challenging reality clinical care leads significant morbidity mortality however currently available treatments modest efficacy high recurrence rates recent years genetic therapy approaches explored preclinical models offer potential treatment modality targeted delivery tissue specificity therapy tailored address mechanisms underlying arrhythmia however many challenges remain gene therapy advance clinically relevant treatment review summarize available published data gene therapy discuss challenges opportunities limitations approach american college cardiology foundation
background objective seas examine association self reported diagnostic statistical manual edition alcohol abuse dependence medical conditions among american indians ais methods analyzed data previously collected large epidemiological study members culturally distinct tribes southwest northern plains living near reservations associations combined self reported alcohol abuse alcohol dependence medical conditions examined multinomial logistic regression results medical conditions significant relationships alcohol abuse dependence sprains strains odds ratio hearing vision problems kidney bladder problems head injuries pneumonia tuberculosis dental problems liver problems pancreatitis total count medical conditions also significantly related alcohol abuse dependence higher count associated outcome conclusions community based study rural als diverse medical conditions associated alcohol abuse dependence research examine confirm nature extent anti tribal variation medical consequences alcohol abuse dependence unique populations
aim study seroprevalence hepatitis virus hcv infection related risk factors aseer region southwestern saudi arabia region known highest endemicity viral hepatitis cross sectional study participants interviewed using structured questionnaire hcv infection diagnosed using fourth generation elisa positive equivocal hcv serology results confirmed using qualitative confirmatory pcr study enrolled participants seroprevalence found multivariate logistic regression analysis study showed males significantly risk become seropositive hcv aor compared females similarly participants history blood transfusion two times risk becoming seropositive hcv aor hcv infection study area still high plateau phase recommended active educational media campaign risks hcv infections workshops training qualified laboratory staff related blood banking seem mandatory wiley periodicals inc
mobile cloud computing uses features deliver outsourcing data remotely available mobile devices however flexible nature mobile device critical challenge mobile cloud computing environment mobile phone significantly degrades data transfer performance initiating handover process thus energy efficient handover process could improve quality service qos introduce secure energy efficient quality service architecture eeqosa handover process mobile cloud computing environment proposed architecture involves four layers application internet protocol multimedia subsystem ipms communication media connectivity layers four layers collectively handle energy efficiency security qos parameters existing service oriented architectures designed mobile cloud computing based symmetric encryption cryptography support different media services however approach easily allows adversary expose symmetric key gain access private data thus proposed architecture uses secure strong authentication ssa process ipms layer protecting media services unauthorized users ipms central layer could entry point adversary furthermore extend mobile lifetime handover process energy detection model deployed communication layer detect energy level mobile device prior handover initialization process media connectivity layer supports secure handover process using priority enforcement module allows legitimate users complete registration process initiating handover finally architecture tested using cloudsim simulation environment validated comparison known service oriented architectures
emotion regulation one important developmental tasks early adolescencehas proposed mediate relation parenting adolescents psychosocial adjustment aim study examine influence parental psychological control autonomy support adolescents problem prosocial behavior strengths difficulties questionnaire well examine mediating role adolescents anger regulation moderating effect gender collected three year longitudinal questionnaire data parents first assessment year old children path analysis results mainly support mediating role adolescents adaptive maladaptive anger regulation suggest parental autonomy support beneficial regulatory abilities psychosocial adjustment whereas opposite found psychological control gender differences found parent report data adolescent report data practical theoretical implications discussed
exponential rational function method relatively new mechanism get exact solutions nonlinear fractional differential equations paper fractional derivatives sense jumarie modified riemann liouville defined fractional complex transform used convert fractional differential equations ordinary differential equations method appropriate solving different kind nonlinear frac tional differential equations emerging mathematical physics
paper propose new fuzzy group multi criteria decision making method apply determine critical path project network criteria used time expected duration cost risk quality project activities considered critical project management criterion independent level importance critical path selection weights project criteria also considered analysis considering information terms various project activities criteria weights often incomplete uncertain real world situations essential information terms criteria project activities obtained using triangular fuzzy numbers linguistic variables mapped triangular fuzzy numbers wherever appropriate proposed method involves fuzzy evaluation based fuzzy information possible project paths criterion leading strength weakness index scores project paths define measure criticality termed total performance score project path obtained using strength weakness index scores path highest measure criticality selected critical path numerical illustration provided demonstrate working proposed methodology case study manufacturing engineering industry also presented better justify applicability potentials proposed methodology comparison closely related fuzzy multi criteria decision methods critical path selection done analyze performance proposed methodology
although overwhelmingly behavior similar males females correspondingly brains similar sex differences permeate brain behavioral measures differences focus increasing scrutiny neuroscientists review describes milestones decades research brain behavior research necessarily bound available methodology began indirect behavioral indicators brain function handedness proceeded use neuropsychological batteries structural functional neuroimaging provided foundations cognitive neuroscience based computerized neurocognitive battery sex differences apparent consistent neurocognitive measures females performing better memory social cognition tasks males spatial processing motor speed sex differences also prominent major brain parameters including higher rates cerebral blood flow higher percentage gray matter tissue higher interhemispheric connectivity females compared higher percentage white matter greater intrahemispheric connectivity well higher glucose metabolism limbic regions males many differences present childhood become prominent adolescence perhaps linked puberty overall indicate complementarity sexes would result greater adaptive diversity wiley periodicals inc
background low physical activity fruit vegetable consumption early childhood continued public health challenges manuscript describes outcomes two pilot studies sustainability via active garden education sage program designed increase consumption among year old children methods sage developed using community based participatory research cbpr delivered children early care education centers ecec two cities children participated one hour sessions included songs games interactive learning activities involving garden maintenance taste tests evaluated reach efficacy adoption implementation potential maintenance sage following aim framework reach evaluated comparing demographic characteristics among sage participants residents target geographic areas efficacy evaluated accelerometer measured consumption eating absence hunger among children parenting practices regarding home availability adoption evaluated number ecec participated relative number ecec recruited implementation evaluated completion rates planned sage lessons activities potential maintenance evaluated parent satisfaction survey results sage reached ecec neighborhoods representing wide range socioeconomic status participants sociodemographic characteristics representing intervention areas children significantly increased sage lessons compared usual lessons also consumed calories absence hunger post pre intervention tests parent reports suggest changes consumption parenting practices home availability possibly due low parent engagement ecec moderate high implementation sage lessons curriculum potential maintenance strong parents rating sage favorably reporting increases knowledge nutrition guidelines young children conclusions sage successfully translated national guidelines practice young children less successful nutrition guidelines high adoption implementation favorable parent reports suggest high potential program sustainability work engage parents families young children ecec based nutrition programming needed
denmark set ambitious long term future energy goal become independent fossil fuel depending completely renewable alternative resources energy transport sectors solar energy one favourable alternative resources terms cleanness safety economic environmental aspects however intermittent nature solar energy lack high solar radiation intensities various climates favour use various energy storage techniques eliminate discrepancy energy supply demand current work presents analysis evaluation performance underground soil based thermal energy storage system solar energy storage coupled combined heat power generation system combined air source heat pump ashp system utilized fulfil heating electricity needs housing project odense denmark addition charging soil storage medium summer months excess electric power generated stored heat discharged december january provide space heating domestic hot water demands residential project without utilization external heating source employing system capacity found storage medium soil capable providing heating needs housing project internal floor area year round transient behaviour thermal energy storage medium reported addition heat losses surrounding soil temperature variation throughout year found overall system heating coefficient performance around reported energetic efficiency standalone system combined ashp system combined ashp system employing seasonal underground thermal energy storage block elsevier ltd rights reserved
background malignancy common etiology acquired fistulae tracheobronchial tree esophagus majority due either primary bronchial esophageal carcinoma typically observed adult population occurrence tracheoesophageal fistula tef patients hodgkin lymphoma rare phenomenon observation report rare case hodgkin lymphoma tef year old girl presentation also developed pulmonary tuberculosis later follow fed nasogastric tube avoid aspiration fistulous tract well chemotherapy anti tubercular therapy conclusions case suggests tef hodgkin lymphoma time diagnosis rare complication pediatric age group lymphoma related tef require far less active intervention esophageal bronchial malignancy related tef
national demand water predicted increase exacerbated growing population home grown demands energy food set context overstretched existing supply sources vulnerable droughts particularly increasingly dense city centres delicate balance matching minimal demands resource secure supplies becomes critical making changes internal demands role technological efficiency user behaviour ignored yet existing benchmarking systems traditionally consider latter paper investigates practicalities adopting domestic benchmarking system using band rating allows individual users assess current water use performance possible benchmarking system allows users achieve higher benchmarks approach reduces water consumption sensitivity water use benchmarks investigated making changes user behaviour technology impact adopting localised supplies rainwater harvesting rwh grey water including external gardening demands investigated includes impacts isolation combination following occupancy rates roof size garden size geographical location north west midlands south east yearly temporal effects rainfall temperature lessons learnt analysis proposed benchmarking system made throughout paper particular compatibility existing code sustainable homes csh accreditation system conclusions subsequently drawn robustness proposed system
excellent matching sorption desorption temperatures hexahydrated srbr required solar heat storage building applications high heat reaction mol water coupled gain loss mol water per mole salt make salt appealing sorbent solar thermal energy storage applications coupled space heating due morphological instability salt necessary incorporate porous matrix composite sorbent new composite material thermochemical energy storage applications developed consists mesoporous silica gel impregnated strontium bromide salt content equal structure sorption properties composite characterized sem edx temperature dependent xrd xrf sorption measurements salt homogeneously distributed inside pores silica gel water sorption isotherms measured degrees degrees enabled understand sorption mechanism mathematical model developed used fit experimental data order predict sorption behavior composite different conditions influence temperature pressure conditions cycle loading lift energy storage density interest using composite thermal energy storage application discussed thermal energy produced solar collector used space heating high cycle loading lift obtained corresponding energy storage capacity energy storage density packed bed composite degrees degrees mbar reported excellent stability sorption desorption cycles sorption kinetics composite enhanced compared pure salt test laboratory scale open type reactor gives maximum specific thermal power mean specific thermal power degrees mbar extent reaction elsevier ltd rights reserved
living cells adapt respond actively mechanical properties environment addition biochemical mechanotransduction evidence exists myosin dependent purely mechanical sensitivity stiffness surroundings scale whole cell using minimal model dynamics actomyosin cortex show interplay myosin power strokes rapidly remodeling actin network results regulation force cell shape adapts stiffness environment instantaneous changes environment stiffness found trigger intrinsic mechanical response actomyosin cortex cortical retrograde flow resulting actin polymerization edges shown modulated stress resulting myosin contractility turn regulates cell length force dependent manner model describes maximum force cells exert maximum speed contract measured experimentally limiting cases found associated energy dissipation phenomena nature taking place contraction whole muscle similarity explains fact single nonmuscle cell whole muscle contraction follow hill like force velocity relationship
proliferation malicious entities distributed environment poses various serious threats protection mobile agent platform map numerous researches proposed ward inherent security risks though solutions enough identify remove vulnerabilities paper self adaptive phase map security architecture proposed inspired biological immune system prime objective detecting unknown malicious mobile agents context data mining methods studied detection unknown malicious executable particular boyer moore pattern matching algorithm gram feature analysis mobile agent using nearest neighbor classifier facilitate discovery known unknown malicious content incoming mobile agent proposed architecture protects man middle mitm attack masquerading attack replay attack repudiation attack unauthorized access attack architecture designed implemented ibm aglets comprehensive fold cross validation scheme large collection malicious non malicious files performed performing classification technique involving feature selection method propitious experimental outcomes express performance time security accuracy proposed architecture outperform earlier known related schemes makes proposed architecture suitable map protection mobile agent environment mae findings exhibit wide ranging newness since concept machine learning never employed far sphere mobile agents system mas hence proposed work likely great interest researchers particularly deal mas security elsevier ltd rights reserved
aims systematically review management lower urinary tract symptoms luts patients dementia associated disorders methods systematic review performed according prisma statement studies identified electronic search embase medline databases last search august screening reference lists reviews results abstracts screened full text articles identified assessed eligibility seventy six articles included quantitative synthesis urinary incontinence prevalence rates dementia patients varied considerably ranging alzheimer disease patients usually correlates disease progression late stage dementia contrast luts usually precede severe mental failure lewy body disease vascular dementia behavioral therapy including toilet training prompted voiding may especially useful patients unawareness high quality data guide choice treatment strategies population lacking current evidence suggests antimuscarinics especially oxybutynin associated cognitive worsening due blockade receptors thus use antimuscarinics easily cross blood brain barrier selective considered data available beta agonists far conclusion different types dementia cause different luts varying time points disease process need singular therapeutic approaches treatment luts tailored individual patient needs disease status considering factors like mobility cognitive function general medical condition wiley periodicals inc
study sending receiving secret messages called cryptography generally senders receivers unaware process encryption decryption hence encryption plays important role data communication data security meaning encryption keep data confidential unwanted access also ensuring data integrity available way capacity breaking security increasing rapidly process hides information one concerned topics advanced encryption standard popular widely used efficient encryption algorithm used since invented paper focuses aes key generation process substitution box modifies conventional key generation technique builds dynamic dimensional box advance encryption standard proposed approach suggests dimensioanl key generation matrix box per shown novel technique increases amount time needs encryption decryption experimental result shows also enhances strength aes algorithm proposed approach illustrates theoretical analysis corresponding experimented results
hydraulic control switching valves excite undesirable hydraulic mechanical oscillations hence control performance inadequate different ways cope oscillations one way change design add damping elements improve attenuation oscillations another way actuate system appropriate way almost unwanted oscillations excited article illustrates optimal feed forward control theory used obtain realisable switching valve command avoids ongoing oscillations case fast position step system composed dual stroke cylinder piston chamber connected switching valves pipeline rod chamber pre pressurised accumulators counterbalancing modelled discrete dynamical system order optimal control problem conditioned resulting valve signals approximately realised existing switching valves realisation called ballistic mode switching valves plays important role theoretical results tested experimentally proper test rig
forging shops started using natural gas fired furnaces heat parts forged use induction heating parts heated faster control semi automatically efficiently less decarb much less scale induction heating much better system heat billets less wasted energy possible use natural gas generate electricity use electricity power operate induction heating systems generating system range kilowatts many megawatts turbine generating system investigate cost payback time type system generation electricity problem electrical noise electrical line induction heating would eliminated harmonics electrical noise heat generating system used purposes called cogeneration heat could used generate steam run forging hammers heat office buildings used absorption type cooling system fuel cell around corner increase efficiency system could reduce cost
identifying water pollution crime seems sensible already characterized way countries however succeed struggle pollution important understand advantage categorization provides particularly international level speaking environmental crimes clearly sends message serious consequences activities societies humanity area gross violations human rights criminalization may help eliminate impunity least climate impunity lawsuits sanctions effective precise conditions sometimes difficult meet terms burden proof criminal law achieving necessary political
existing computational pipelines quantitative analysis high content microscopy data rely traditional machine learning approaches fail accurately classify single dataset without substantial tuning training requiring extensive analysis demonstrate application deep learning biological image data overcome pitfalls associated conventional machine learning classifiers using deep convolutional neural network deeploc analyze yeast cell images show improved performance traditional approaches automated classification protein subcellular localization also demonstrate ability deeploc classify highly divergent image sets including images pheromone arrested cells abnormal cellular morphology well images generated different genetic backgrounds different laboratories offer open source implementation enables updating deeploc new microscopy datasets study highlights deep learning important tool expedited analysis high content microscopy data
rural areas northwest china rainwater harvesting appears promising alternative supplying drinking water face increasing water scarcity escalating demand quality collected cistern rainwater rural northwest china assessed results show collected cistern rainwater quality parameters rural northwest china conformed drinking water quality standard china except turbidity codmn total coliforms disinfection system proposed polish collected cistern rainwater treatment removal efficiencies turbidity codmn total coliforms respectively treatment collected cistern rainwater could provide water adequate safe drinking water guidelines
deleterious effects school burnout academic related stress academic physiological cognitive outcomes previously established however school burnout relationship emotional relationship outcomes well underlying factors contributing potential relationship less understood therefore three studies conducted fill gap examining relationship school burnout self control emotional dysregulation intimate partner violence emerging adult samples results demonstrate school burnout positively associated emotional dysregulation independent anxiety depression study self control moderates relationship study well relationship school burnout intimate partner violence perpetration victimization study specifically relationship school burnout emotional dysregulation study well victimization perpetration study stronger lower levels dispositional self control findings studies identify school burnout important phenomenon inquiry relation psychosocial outcomes among emerging adults importantly findings suggest self control may serve potential point intervention ameliorating school burnout damaging effects limitations directions future research discussed elsevier ltd rights reserved
intelligent environments aim provide context sensitive services humans physical spaces work live ethical dimensions systems considered aspect requires analysis literature review shows approaches disconnected making little impact real systems built article provides solution problems synthesises ethical issues addressed previous work highlights important concerns overlooked far furthermore proposes alternative holistic approach used guide development intelligent environments validity framework demonstrated integration actual project
platelet lymphocyte plr neutrophil lymphocyte nlr ratios extensively investigated cancer however date actual guidelines concerning ovarian cancer missing purpose present systematic review summarize available evidence systematically searched medline scopus clinicaltrials gov cochrane central register controlled trials central databases together reference lists included studies eighteen studies included present systematic review involved patients according current data plr nlr values ovarian cancer patients seem deviate healthy controls furthermore may also indicative stage disease response chemotherapy nevertheless diagnostic accuracy remains limited sensitivity specificity moderate detects ovarian cancer women according findings study plr nlr seem promising screening prognostic factors epithelial ovarian cancer actual diagnostic cut values remain however undefined despite limited sensitivity specificity might useful future adjunct biomarkers detection surveillance disease
today highly demanding customers aggressive competitors product development getting complex needs innovate continuously hand common direction towards cost savings shortening design cycle forces make product design process highly efficient high level performance accordingly paper provides new creative design tool support robust product development taking advantage creativity based design process achieve goals innovative product design describes pilot prototype software system used computer aided product development developed based characteristics product design process integrating creative thinking methods information technologies computer application technologies cad system labview game technology etc new design environment leads flexible working flow designing product hand hand searching product library arranged geometric properties allows designers engineers professionals collaborate platform product development process
order monitor carbon monoxide industrial production developed passive gas radiation measurement system based fourier transform infrared spectroscopy carried infrared radiation measurement experiment carbon monoxide detection simulated industrial production environment system principle condition device data processing method experiment introduced paper order solve problem light path jitter actual industrial field simulated noise industrial environment combine advantages mathematica software aspects graph processing symbolic computation data processing improve signal noise ratio noise suppression based hitran database nonlinear least square fitting method used calculate concentration spectra data processing comparing calculated concentration data processed mathematica reliable necessary industrial production environment
background autoimmune gastritis aig gastric pathologic condition affecting mucosa fundus body eventually leading hypo achlorhydria aims report clinical pathological experience aig methods data patients diagnosis aig seen period january december retrieved patients complete sets biopsies analyzed results data patients available analysis pernicious anemia present patients iron deficiency anemia found patients hypothyroidism patients type diabetes patients vitiligo patients parietal cell antibodies positive patients patient serology positive celiac disease gastric biopsies showed glandular atrophy associated enterochromaffin like ecl cells hyperplasia features limited mucosa fundus body focal glandular intestinal metaplasia helicobacter pylori negative cases conclusions aig strongly associated anemia atrophy intestinal metaplasia ecl hyperplasia gastric fundus body hallmarks condition
background atopic dermatitis appears common regions hard domestic water children fall winter birth however unknown whether synergistic effect exists objective sought evaluate association domestic water hardness season birth respectively onset within first months life large danish birth cohort methods children danish national birth cohort included history physician diagnosed population characteristics obtained interviews birth data obtained civil registration system domestic water hardness data obtained geological survey denmark greenland relative prevalence calculated using log linear binomial regression results prevalence rptrend higher increase domestic water hardness range german degrees hardness although higher children fall winter birth significant interaction observed domestic water hardness population attributable risk hard domestic water conclusion observed early exposure hard domestic water fall winter birth associated increase relative prevalence within first months life although exposures interact synergistically doseresponse relationship observed domestic water hardness
aim augmentation late sodium current causes intracellular accumulation results intracellular overload via reverse mode exchange current reverse ncx also prolongs apd induces early afterdepolarizations ead lead arrhythmia cardiac dysfunction thus inhibition considered potential way therapeutic intervention ischemia heart failure study investigated effects tolterodine tol competitive muscarinic receptor antagonist normal veratridine ver augmented reverse ncx apd isolated rabbit ventricular myocytes might contribute cardioprotective activity methods rabbit ventricular myocytes prepared reverse ncx recorded voltage clamp mode whereas action potentials ver induced early afterdepolarizations eads recorded current clamp mode drugs applied via superfusion results tol nmol concentration dependently inhibited normal ver augmented values nmol nmol respectively atropine mol affect inhibitory effects tol nmol ver augmented contrast much high concentrations tol needed inhibit transient sodium current value mol addition tol nmol significantly shifted inactivation curve toward depolarizing membrane potential without affecting activation characteristics moreover tol nmol significantly decreased ver augmented reverse ncx tol nmol increased action potential duration apd basal conditions ver mol considerably extended apd evoked eads cells presence ver tol nmol markedly decreased apd eliminated eads cells conclusion tol inhibits normal ver augmented nal decreases ver augmented reverse ncx addition tol reverses prolongation apd eliminates eads induced ver thus prevents ver induced arrhythmia
methyl cpg binding protein mecp deleterious variants responsible rett syndrome girls involved wide spectrum developmental disabilities males neuropsychiatric phenotype without intellectual disability uncommon patients mecp deleterious variants report two dizygotic twins mecp related psychiatric disorder without intellectual disability neuropsychological psychiatric phenotype assessments performed genetic analysis carried patients fulfilled pervasive developmental disorder criteria autism diagnostic observation schedule asperger syndrome criteria diagnostic statistical manual mental disorders dsm one patient developed early onset schizophrenia dsm criteria two acute psychotic episodes latest one following corticosteroids sodium valproate intake major hyperammonemia novel mecp gene transversion serile found twins pathogenicity variant considered basis strong clinical molecular data underlying molecular basis neuropsychiatric disorders may important consequences genetic counseling therapeutic strategies copyright wolters kluwer health inc rights reserved
integrability multi shock wave solutions djkm equation studied means bell polynomials scheme hirota bilinear method symbolic computation generalized bilinear system djkm equation constructed via bell polynomials scheme moreover lax pair infinite conservation laws equation first obtained via corresponding bell polynomials type backlund transformation furthermore multi shock wave solutions also obtained applying standard hirota bilinear method propagation collision shock waves graphically demonstrated graphs
poly vinylidene fluoride pvdf nanocom posite incorporated polydopamine coated reduced graphene oxide rgo pdopa nanosheets developed high dielectric permittivity low loss electricity storage applications structural analysis indicates pdopa successfully anchored onto rgos non covalent linkage mild conditions presence pdopa layer rgo pvdf prevent agglomeration direct contact original rgos also enhance interaction pvdf rgo microcapacitor formation compared rgo pvdf composites higher dielectric permittivity lower loss factor achieved simultaneously rgo pdopa pvdf nanocomposites low moderate frequencies pdopa interface layers effective modifying dielectric characteristics composites increase dielectric permittivity without introduction loss mechanisms study demonstrates pdopa ideal interface layer development new percolative dielectric composites high dielectric permittivity low loss
many computer vision medical imaging problems faced learning large scale datasets millions observations features paper propose novel efficient learning scheme tightens sparsity constraint gradually removing variables based criterion schedule attractive fact problem size keeps dropping throughout iterations makes particularly suitable big data learning approach applies generically optimization differentiable loss function finds applications regression classification ranking resultant algorithms build variable screening estimation extremely simple implement provide theoretical guarantees convergence selection consistency addition one dimensional piecewise linear response functions used account nonlinearity second order prior imposed functions avoid overfitting experiments real synthetic data show proposed method compares well state art methods regression classification ranking computationally efficient scalable
background increased susceptibility autoimmune disease shown patients atopic dermatitis data remain scarce inconsistent objective examined occurrence selected autoimmune diseases adult patients methods nationwide health registers used adult patients hospital diagnosis denmark included cases matched controls occurrence autoimmune diseases compared groups logistic regression used estimate odds ratios results significantly associated examined autoimmune diseases addition associated multiple autoimmune comorbidities patients history smoking significantly higher occurrence autoimmune comorbidities compared nonsmokers limitations study limited adult patients information severity degree tobacco consumption available results hospital population patients generalized general population conclusions results suggest susceptibility autoimmune diseases adult patients especially smokers conclude causality based data increased awareness autoimmune comorbidities patients may warranted
affective temperaments subclinical manifestations phenotypes mood states hypothetically represent one healthy end mood disorder spectrum however scarcity studies investigating neurobiological basis affective temperaments one fundamental aspect temperament behavioral reactivity environmental stimuli effectively evaluated use cognitive event related potentials erps reflecting diversity information processing aim present study explore associations affective temperamental traits healthy individuals recorded erp waves using auditory oddball paradigm medical student volunteers females males participants affective temperaments evaluated using temperament evaluation memphis pisa paris san diego auto questionnaire version temps bivariate analyses depressive temperament score significantly correlated latency multiple linear regression analysis latency showed significant positive correlation scores depressive temperament significant negative one scores cyclothymic temperament affective temperament scores associated amplitude reaction times results indicate affective temperaments related information processing brain depressive temperament may characterized decreased physiological arousal slower information processing opposite observed cyclothymic temperament
dielectric behavior polyacrylonitrile derived carbon nanofibers formed different carbonization temperatures investigated using impedance spectroscopy impedance data presented form cole cole plots four equivalent electrical circuits derived found increasing carbonization temperature degrees strong capacitive element parallel equivalent circuit transformed inductive element contact resistance parallel resistance significantly decreased along morphological chemical structural evolution respectively witnessed scanning electron microscopy raman spectroscopy dielectric transition deduced transformation electrical circuits correlated proposed microstructural changes polyacrylonitrile derived carbon nanofibers interaction interference among
bim technology kind brand new concept involves series innovation change planning design theory construction maintenance technology development trend information construction bim technology research important application value broad application prospects building life cycle management extremely vital significance improve level construction design construction operation scientific technological level promote construction industry level modernization informatization
hepatitis virus hcv reported hijack fatty acid metabolism infected hepatocytes taking advantage lipid droplets virus assembly study analyzed anti hcv activity carnitine substance involved transport fatty acids mitochondria jfh hcv replicontransfected huh cells treated without carnitine examine anti hcv effects effects carnitine hcv entry hcv induced adipogenesis lipid droplet formation hcv induced oxidative stress examined treatment jfh infected cells carnitine inhibited hcv propagation concentration dependent manner contrast carnitine antihcv activity hcv replicon system lacking viral assembly addition lcarnitine affect hcv entry however lcarnitine treatment decreased intracellular lipid droplets crucial hcv assembly jfh infected cells expression level cpt decreased jfh infected cells carnitine treatment restored expression hcv infected cells exhibited increased production reactive oxygen species glutathione oxidation carnitine decreased oxidative stress induced jfh infection shown glutathione glutathione disulfide assays mitosox staining carnitine exhibited anti hcv activity possibly inhibiting hcv assembly anti adipogenic activity hcv infected cells moreover carnitine antioxidant properties hcvinfected hepatocytes overall results indicated carnitine may effective adjunctive agent antiviral therapies treat chronic hepatitis wiley periodicals inc
environmental exposures pregnancy may increase breast cancer risk mothers female offspring tumor tissue assays may provide insight regarding mechanisms study assessed feasibility obtaining tumor samples pathology reports mothers enrolled child health development studies pregnancy daughters developed breast cancer years follow breast cancer cases identified linkage california cancer registry self report written consent obtained breast cancer survivors access pathology reports tumor blocks contacted consented refused respond obtained tissue samples pathology reports diagnosis made years obtained tissue samples pathology reports respectively obtaining pathology reports tumor tissues two generations feasible support investigation relationship early life exposures molecular tumor markers however found recent diagnosis increased accessibility tumor tissue recommend cohorts request consent obtaining future tumor tissues study enrollment implement real time tissue collection enhance success collecting tumor samples data
controlling geometric parameters weld pool weld bead main method getting better welding quality industrial robotic welding paper presents technology real time welding process sensor necessary improve welding quality using intelligent robot gas metal arc welding process set vision systems consists active vision sensor passive vision sensor designed clear steady images weld pool obtained passive vision part images laser stripe projected weld bead obtained active vision part time features acquired images analyzed geometric parameters weld cross section weld pool successfully extracted images detection precision system also analyzed
paper presents new approach infer worldwide malware infected machines solely analyzing generated probing activities contrary adopted methods proposed approach rely symptoms infection detect compromised machines allows inference malware infection early stages contamination approach aims detecting whether machines infected well pinpointing exact malware type family latter insights allow network security operators diverse organizations internet service providers backbone networks promptly detect clients compromised machines addition effectively providing tailored anti malware patch solutions achieve intended goals proposed approach exploits darknet internet space initially filters misconfiguration traffic targeting space using probabilistic model subsequently approach employs statistical methods infer large scale probing activities perceived dark space consequently activities correlated malware samples leveraging fuzzy hashing entropy based techniques proposed approach empirically evaluated using recent real darknet traffic thousand real malware samples results concur rationale exploiting probing activities worldwide early malware infection detection indeed promising results validated using publically available data resources demonstrate extracted inferences exhibit noteworthy accuracy generate significant cyber security insights could used effective mitigation elsevier rights reserved
home visitation programs designed provide comprehensive services promote parent abilities create stable nurturing care environments children order program goals met parents must participate actively engaged programs mission however promoting engagement participation complex processes understudied research home visitation current qualitative study examined national federally funded home visitation program early head start ehs engaged retained families potentially helpful preventative interventions could delivered study also identified barriers active engagement semistructured interviews conducted parents children enrolled ehs findings suggest engagement increased ehs reduced social isolation forming connections among parents program focused involving parents fostering children meeting important developmental milestones barriers engagement identified included logistical organizational challenges well parental biases differences values attitudes practice policy recommendations improving ehs programs serve similar populations increase engagement discussed
reder duncan well known studies fatal child abuse drew attention parental scripts regarding children could dangerously distort relationships ways sometimes fatal children article reports new system assessing meaning child parent called meaning child interview motc parents interviewed using established parent development interview equivalent transcript interview analysed according parental sensitivity likely risk child motc constructs developed used observed parent child interaction specifically care index form discourse analysis used dynamic maturational model adult attachment interview allowing systemic inter subjective understanding parenting representations often put forward article discusses theoretical background motc gives brief review similar measures introduces coding system patterns caregiving validity motc addressed elsewhere
nowadays elders often find difficult keep track cognitive functional abilities required remaining independent homes ambient assisted living aal ambient intelligence based technologies support daily activities elders traditional rehabilitation example common activity elders may require usually implies move rehabilitation clinics main reason treatment discontinuation tele rehabilitation solution may help elders also family members health professionals monitor elder treatment purpose paper present tele rehabilitation system uses motion tracking sensor kinect allow elderly users natural interaction combined set external sensors form input data fusion techniques applied order integrate data detecting right movements monitor elder treatment rehabilitation process
analysing gender roles social organisation element community critical understanding actors rationales agency regard allocation use resources article discusses gender relations determine development outcomes based highland lowland case study participants farmer field schools kakamega central sub county highland mbeere south sub county lowland gender relations stake include gendered division labour gender roles intra household power relations expressed access control resources benefits implications agricultural development study used mixed methods harvard analytical framework gender roles draws neo marxist position exploitation categorisation institutionalisation power relations empowerment critical moments framework discuss results results sub counties show patriarchy prevails determining institutional design access control resources benefits social positions shape capabilities strategies actors decision making use resources justify gender specific institutional arrangements kakamega men get lion share incomes contracted sugarcane farming despite overburdening workloads women mbeere men women derive incomes khat catha edulis enterprises however women expected spend earnings household expenditures hitherto responsibilities men thereby contributing feminisation responsibilities development policies interventions thus need based understanding men women differential access control resources institutions underpinning men women bargaining power order adopt effective measures reduce gender inequalities resumenanalizar los roles genero como elemento organizacion social una comunidad fundamental para comprender los fundamentos las los actores agencia con respecto asignacion uso los recursos este articulo analiza las relaciones genero como estas determinan los resultados del desarrollo basandose estudio caso participantes las tierras altas bajas farmer field schools subcondado kakamega tierras altas subcondado mbeere tierras bajas las relaciones genero cuestion incluyen division del trabajo por genero los roles genero las relaciones poder intra hogar expresadas acceso control los recursos los beneficios sus implicancias para desarrollo agricola estudio utiliza metodos mixtos marco analitico harvard sobre los roles genero basa una postura neomarxista sobre explotacion categorizacion institucionalizacion las relaciones poder empoderamiento marco analitico momentos clave para analizar los resultados ambos subcondados los resultados muestran que prevalece patriarcado determinando diseno institucional acceso control los recursos beneficios las posiciones sociales dan forma las capacidades las estrategias los actores toma decisiones uso recursos para justificar los arreglos institucionales especificos genero kakamega los hombres quedan con mayor parte los ingresos del cultivo contratado cana azucar pesar sobrecarga trabajo que hay sobre las mujeres mientras que mbeere tanto estas como los varones obtienen ingresos los emprendimientos del khat catha edulis sin embargo espera que las mujeres utilicen sus ingresos para gastos del hogar los que solian ser responsabilidad los hombres contribuyendo asi feminizacion las responsabilidades las politicas intervenciones desarrollo por tanto necesitan basarse entendimiento del diferente acceso control los recursos entre hombres mujeres las instituciones que apuntalan poder negociacion entre ambos para poder adoptar medidas mas efectivas para reducir las desigualdades genero
egyptian aquaculture gaining importance affordable nutritious source animal protein among egyptians nile tilapia dominates production total production followed carps mullets egyptian tilapia farmers however facing challenges regards financial viability poor water quality fish farms also contributing towards water pollution environmental impacts order improve situation worldfish launched ieideas project ambition train farmers best management practices bmp distribute generation abbassa strain present study aimed evaluating relative environmental gains bmp offers compared conventional farming using life cycle assessment lca inventory data representing farmers four groups control bmp bmp evaluated life cycle impact assessment results including quantitative uncertainties calculated statistically tested using monte carlo analysis wilcoxon paired significance test five impact categories explored global warming eutrophication acidification freshwater consumption land use stain offered greatest improvements across evaluated impact categories significantly reducing environmental impacts bmp meantime offered significant improvements compared control regards eutrophication acidification freshwater consumption land use meanwhile bmp performed comparably except eutrophication significantly larger environmental footprint efficient feed utilization higher productivity main reasons environmental improvements additional improvements explored include improved feeds made sustainably sourced raw materials better pond water management including probiotics paddle wheels statement relevance bmp improved stains help reduce environmental impacts elsevier rights reserved
paper presents case history performance coastal embankment reinforced layer geotextile bottom embankment soft marine deposits coastal embankment sea wall qinshan nuclear power station northern side hangzhou bay near shanghai china monitoring settlement excess pore water pressure carried embankment construction finite element method fem used analyse performance geotextile reinforcement effect soil behaviour embankment loading based field monitored results stability analyses conducted using two approaches phi reduction fem limit equilibrium analysis field simulation results indicate geotextile effect reducing vertical displacements subsoil however results show basal reinforcement increase overall factor safety factor safety local position reinforcement increased construction procedure due confinement soil element reinforcing fabric thus circumstances one layer basal geotextile reinforcement prevent sudden failure subsoil embankment construction elsevier ltd rights reserved
aimed implement extension community healthcare outcomes echo tele mentoring model hepatitis evaluate outcomes health providers following echo model hepatitis teleecho clinic established hospital italiano argentina teleecho clinic provides support training physicians patagonia treat patients hepatitis order evaluate teleecho clinic outcomes physicians completed survey focused skills competence hepatitis months participating project survey consisted questions participants rated ability highest ability analyze difference participation project wilcoxon signed rank test used first months implementation model total physicians sites patagonia agreed participate survey median age participants years participants primary specialties hepatology infectious diseases general practice significant improvement observed evaluated fields month participation teleecho clinic namely fibrosis staging determining appropriate candidates treatment selecting appropriate hcv treatment addition general interest hepatitis increased successfully replicated implemented first teleecho clinic argentina physicians improved ability provide best practice care patients hepatitis wiley periodicals inc
hardness cations ubiquitous abundant source water effect hardness performance coagulation dissolved organic matter dom removal water treatment remains unclear due limitation methods characterise subtle interactions dom coagulant hardness cations work quantified competition coagulant hardness cations bind onto dom using absorbance spectroscopy acquired different concentrations absence presence results indicate presence either increasing depression binding dom could observed differential spectra dom increasing level observation significant higher results zeta potentials dom indicate competition hardness cations results negative dom less efficiently neutralised study demonstrates removal dom coagulation would significantly deteriorate presence hardness cations would compete coagulant neutralise unsaturated sites dom elsevier ltd rights reserved
present model analysis optimization problem magnetostrictive harvesting device converts mechanical energy repetitive process vibrations smart material electrical energy supplied electric load model combines lumped differential equation simple electronic circuit operator model complex constitutive law magnetostrictive material operator based formalism phenomenological preisach model describes nonlinear saturation effects hysteresis losses typical magnetostrictive materials thermodynamically consistent fashion prove well posedness full operator differential system establish global asymptotic stability periodic regime periodic mechanical forcing represents mechanical vibrations due varying environmental conditions show existence optimal solution problem maximization output power respect set controllable parameters periodically forced system analytical results illustrated numerical examples optimal solution elsevier rights reserved
dependence imported gas increasing rising year total gas consumption used electricity generation year dependence imported gas gas supply interruptions significant impacts energy system economy points need integrated electricity gas modelling tools fully explore potential impacts gas supply interruptions paper builds applies detailed publically available integrated electricity gas model use model examine number hypothetical scenarios gas supply routes interrupted yearly periods impacts power system operation gas flow europe observed model results show interruption russian gas supply could lead rise average gas prices electricity prices supply north africa removed southern european states affected heavily spain particular saw large increases gas prices corresponding rise electricity prices result addition supply interruptions gas storages removed model examine importance gas storage infrastructure resulted average increase power prices across europe additional insights offer increased understanding interplay gas power systems identify challenges may arise seeking understand energy systems whole elsevier ltd rights reserved
experiencing self agency one action outcomes essential social functioning recent research revealed patients schizophrenia use implicitly available information action outcomes prime based agency inference arrive self agency experiences examined whether related symptoms familial risk develop disease fifty four patients controls unaffected unrelated siblings performed agency inference task experienced agency measured action outcomes matched mismatched outcome primes presented action performance positive negative syndrome scale panss comprehensive assessment symptoms history cash administered assess psychopathology impairments prime based inferences differ patients symptoms underattribution however patients agency underattribution symptoms reported significantly lower overall self agency experiences siblings displayed stronger prime based agency inferences patients weaker prime based inferences healthy controls however differences statistically significant findings suggest impairments prime based agency inferences may trait characteristic schizophrenia moreover study may stimulate research familial basis clinical relevance impairments implicit agency inferences
given graph non negative integer restricted connectivity denoted kappa defined minimum size set nodes subset disconnected degree component least restricted connectivity measure generalization traditional connectivity measure improves connectivity measurement accuracy moreover studies revealed network possesses restricted connectivity property reliable demonstrates lower node failure rate compared networks dimensional locally twisted cube ltq well known interconnection network parallel computing variant hypercube studies examined restricted connectivity networks conditions paper examines generalized restricted connectivity measure dimensional locally twisted cube reveals kappa ltq elsevier rights reserved
report case young boy recurrent facial edema third year life diagnosed later hereditary angio edema hae died severe fatal laryngeal attack age eleven father milder hae attacks age diagnosed systemic lupus erithematosus oldest brother recurrent abdominal pain attacks long asymptomatic period family history revealed another three members died suffocated different ages without diagnosis death young boy happened small hospital two hours admission ineffective procedures performed consider hae severity fatality risk underestimated medical staff fatal outcome hae attack youngest child could possibly prevented better equipped medical unit case highlights need raise profile hae within medical community improve prophylaxis treatment potential fatal disease
newtonian fluid dynamics simulations performed using navier stokes fourier formulations elucidate short time scale longer evolution density temperature distributions argon gas filled attenuator ray free electron laser high repetition rate operation hydrodynamic motions gas molecules thermal conductions included finite volume calculation found hydrodynamic wave motions play primary role creating density depression also known filament advectively transporting gas particles away ray laser gas interaction region large pressure temperature gradients built upon initial energy deposition via ray photoelectric absorption subsequent thermalization concurrent outward heat conduction tends reduce pressure filament core region generating counter gas flow backfill filament initially slower time scale inter pulse separation sufficiently short filament recover depth filament progressively increases trailing pulses remove additional gas particles since rate hydrodynamic removal decreases rate heat conduction back flow increases time elapses two competing mechanisms ultimately reach dynamic balance establishing repeating pattern pulse cycle performing simulations higher repetition rates lower per pulse energies maintaining constant time averaged power amplitude hydrodynamic motion per pulse becomes smaller evolution temperature density distributions approach asymptotically towards expected calculated continuous wave input equivalent power
complex construction program usually consists group interrelated projects different levels importance degrees certainty currently time management construction program uses techniques single project commonly used technique critical path method cpm however cpm method lacks flexibility handling uncertainties options desirable feature managing complex programs paper proposes new scheduling method drawn authors experiences managing large scale construction program shanghai expo facility construction new method developed basis traditional cpm method able incorporate options importance levels program schedule theoretical basis calculation method new scheduling technique discussed context managing shanghai expo facility construction program paper contributes body knowledge construction management developing new scheduling technique proven applications american society civil engineers
paper aims provide account school leaders kazakhstan learn leadership management strategies place support leadership development paper draws empirical data collected three years derived mainly interviews focus groups school leaders teachers findings suggest hierarchical education system strict policy regulations diminish likelihood changes needed encourage leadership practice teachers take place paper examines kazakhstani school leaders learning opportunities focuses implications borrowing leadership theories west key argument genuine change occur leaders require time space critical reflection need learn paper raises important issues conceptualisation leadership learning development non western contexts
background risk melanoma hematologic cancers patients psoriasis controversial objective sought assess risk melanoma hematologic cancers patients psoriasis association different treatments methods used case control retrospective cohort designs determine melanoma hematologic cancer risk patients psoriasis risk treatment type assessed using fisher exact test results patients psoriasis times greater risk developing malignancy compared patients without psoriasis significant differences malignancy risk among patients treated topicals phototherapy systemics biologic agents patients psoriasis malignancy significantly worse survival patients without psoriasis limitations possible patients developed malignancy subsequent follow time included study conclusion patients psoriasis may experience elevated risk melanoma hematologic cancers compared general population risk increased systemic biologic psoriasis therapies
introduction despite intense research efforts still little known biological determinants depression thus soliciting diverse study approaches among others electroretinography erg proposed even putative proxy retinal measurement central dopaminergic activity major depressive disorder mdd drug naive patients subjects receiving antidepressant treatments nonetheless current evidences merely preliminary essentially considering older classes antidepressants thus requiring confirmation studies even newer agents duloxetine method twenty mdd subjects matched controls received duloxetine day weeks monitored standard erg recording administration hamilton scales depression anxiety young mania rating scale baseline week end study results erg mean rod wave amplitude significantly reduced baseline week depressed subjects achieving final response decreasing highest rank values ones substantially unmodified seen among non responders controls limitations small sample size lack multiple assessments conclusions least mdd patients responding duloxetine might exhibit peculiar erg pattern hypothetically indicating specific biological background confirmed larger sampled studies results might shed light understanding biological determinants different subtypes depression ideally showing alternative patters response upon different treatment interventions elsevier rights reserved
chronic food restriction potentiates behavioral cellular responses drugs abuse dopamine receptor agonists administered systemically locally nucleus accumbens nac however alterations nac synaptic transmission underlying effects incompletely understood ampa receptor trafficking major mechanism regulating synaptic strength previous studies shown sucrose amphetamine rapidly alter abundance ampa receptor subunits nac postsynaptic density psd manner differs food restricted adlibitum fed rats study examined whether food restriction absence reward stimulus challenge alters ampar subunit abundance nac psd food restriction found increase surface expression specifically psd abundance glua glua suggesting synaptic incorporation glua lacking permeable ampars ampars naspm antagonist ampars decreased amplitude evoked epscs nac shell blocked enhanced locomotor response local microinjection receptor agonist skf food restricted adlibitum fed subjects although microinjection receptor agonist quinpirole also induced greater locomotor activation food restricted adlibitum fed rats effect decreased naspm taken together present findings consistent synaptic incorporation ampars receptor expressing medium spiny neurons nac mechanistic underpinning enhanced responsiveness food restricted rats natural rewards drugs abuse
determine effect piragliatin qtcs corrected study specific interval double blind double dummy placebo controlled active comparator period treatment sequence randomized crossover trial performed patients type diabetes mellitus received piragliatin twice daily placebo moxifloxacin day day days categorical analyses piragliatin clinically significant effect qtcs interval either dose majority patients categorized low risk maximum change baseline milliseconds maximum postbaseline qtcs interval normal milliseconds however analysis variance model piragliatin doses crossed millisecond threshold twice daily day hour twice daily days hours values indicating statistical significance headache mild hypoglycemia frequent adverse events associated piragliatin treatment appeared effect piragliatin treatment qtc interval dose exposure dependent following short term multiple doses longer term monitoring electrocardiograms pharmacokinetic exposure continue especially conditions potentially higher pharmacokinetic exposure
complications embedded applications increasing within due time delivery market also pressure demand use real time operating systems also increasing however redundant fact real time operating system real time significantly degrade performance face performance degradation real time task manger rttm presented paper real time task manger hardware based extension processor decreases performance bottleneck attributed real time operating system real time task manger decreases performance bottlenecks introduced real time operating system hardware based architecture architecture real time task manger discussed paper provides aid deal common operations real time operating system reason performance degradation example event management time management task scheduling operations property inborn parallelism real time task manger uses property complete operations constant time result minimizes overhead introduced real time operating system proposed architecture yields two benefits reduces processor time taken real time operating system improves response time considerable amount
vibrational comfort one important parameters evaluated cyclists bicycle riding method measuring saddle vibration transmissibility developed aim comparing comfort properties bicycle saddles without influence full bicycle frame using quantitative approach three different bicycle saddles mounted stiff seatpost clamped extremity vertical servohydraulic cylinder saddles loaded uni standard wooden dummy bottom carrying deadweights applying sinusoidal sweep amplitude cylinder steps application two piezoelectric accelerometers allowed evaluating magnitude transfer function input acceleration cylinder shaft output acceleration dummy range three curves transfer function magnitude compared analyzed order introduce vibrational comfort index rank tested saddles engineering quantitative point view authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
semantic web uses ontological descriptions particularly web ontology language owl universal medium formally describe exchange knowledge various domains currently many owl ontologies different domains come successively therefore store owl ontologies becomes one ordinary needs semantic web based efficient storage mechanism object oriented databases may used store owl ontologies realizing management large amounts knowledge semantic web end main objective paper investigate store owl ontologies object oriented databases propose formal approach develop prototype tool storing owl ontologies object oriented databases firstly giving complete formal definition owl ontologies propose overall architecture storing owl ontologies object oriented databases based architecture give storage rules explain store owl ontologies object oriented databases running example detail correctness quality storage approach proved analyzed finally implement prototype tool store owl ontologies widely used open source object database dbo also query interface developed prototype tool querying stored owl ontologies storage query examples provided show approach feasible tool efficient elsevier rights reserved
lateral flow tests lfts well suited rapid point care testing low resource settings wicking action paper strip moves sample reagents device without need pumps lfts typically limited tests carried single fluidic step materials lfts reconfigured create paper networks automatically carry multi step fluidic operations retaining easy use format conventional lft describe basic principles wicking system level behavior paper networks analogy electrical circuits describe key design principles previously developed paper network dpn introduce alternative linear paper network pseudo dpn takes advantage system level behavior perform clean sequential fluid delivery reducing device running time
background overlap syndrome primary biliary cholangitis formerly called primary biliary cirrhosis primary sclerosing cholangitis extremely rare condition never described association immune mediated diseases including psoriatic arthritis treatment anti tumour necrosis factor alpha tnf alpha agents proved effective inflammatory arthropathies psoriatic arthritis employed limited number patients autoimmune hepatitis effectiveness unclear case presentation report case year old female affected psoriatic arthritis concomitant overlapping primary biliary cholangitis primary sclerosing cholangitis months adalimumab treatment improved symptoms inflammatory arthropathy well cholangiopathies conclusion results suggest studies examining therapeutic role particular tnf blocker warranted cholestatic autoimmune hepatitis patients particular individuals disease associated inflammatory arthropathies
novel type hydraulic structure proposed rainwater harvesting arid area jordan project develop irrigation scheme near dead sea low annual precipitation high salinity major concerns scheme consists irrigated farm reservoir intake structure divert ephemeral flood flows reservoir harvested water expected fresh comparison groundwater vulnerable freshwater lens research focusses hydraulic design actual construction processes structure structure consists gutter cutting across wide valley bottom conveyance channel long guide water reservoir conveyance channel equipped spillway part result level surveys hydrological considerations revealed structure width supercritical flows dominant details structure dimensions designed numerical model experiments finite volume scheme two dimensional shallow water equations used numerically reproduce whole flow field rainwater harvesting event maximum design discharge numerical scheme employs special fluxsplitting data reconstruction techniques realize stable computation shallow transcritical flows distorted hydraulic model horizontal scale roughness scale constructed experimental station japan order test hydraulic phenomena numerical method represent structure actually constructed site channel bottoms made reinforced concrete side walls concrete blocks whose sizes chosen according design however minor changes made construction processes due workability constraints numerical experiments conducted confirm actual structure showing desired performance
synthesis patient data certain medical image modality applying image processing pipeline starting modality receiving lot interest recently allows save acquisition time sometimes avoid radiation patient example creation computerized tomography volumes magnetic resonance imaging data useful several applications electromagnetic simulations cranial morphometry attenuation correction pet systems present fast patch based algorithm purpose implemented using graphics processing unit computing techniques gaining speedup multicore cpu solution single core cpu solution
subset female patients severe constipation report overlapping uro gynecological symptoms attributed visceral hypersensitivity study colon morphology motor function female patients medically refractory chronic constipation without uro gynecological symptoms assess clinical outcomes following laparoscopic ileo proctostomy colon anatomy cecal emptying time assessed plain films fluoroscopy following standardized test meal mixed barium transit time determined radiopaque markers ibs qol urinary incontinence questionnaires employed assess post colectomy clinical response consecutive patients mean colon transit time significantly greater normal subjects mega cecum found group mean cecal volume significantly greater six without mega cecum group mean cecal empting time days barium mixed feces group significantly greater group eighteen patients groups laparoscopic ileo proctostomy experienced significantly improved quality life particular group patients benefited significantly improved uro gynecological symptoms hitherto unrecognized mega cecum markedly impaired emptying function found patients severe slow transit constipation uro gynecological symptoms subtotal colectomy relieved constipation improved significantly uro gynecological symptoms suggesting strongly mega cecum causally related symptoms
background exposure human skin solar ultraviolet uva irradiation causes severe oxidative stress damage various cellular components concomitant inflammation carcinogenesis objective aim study investigate protective effect acetyl keto boswellic acid akba uva radiation human skin keratinocytes methods hacat cells pretreated akba followed uva irradiation radiation effects cell morphology cell viability intracellular reactive oxygen species ros levels antioxidant enzymes examined results akba reduces uva irradiation induced cell viability loss accompanied decreased production uva induced ros decreased malondialdehyde increased superoxide dismutase expression addition akba increased basal uva induced levels nrf related factor redox sensitive factor target genes nqo heme oxygenase whereas expression tran scriptional repressor bach btb cnc homology reduced furthermore cytoprotective effects akba uva derived oxidative damage accompanied modulating expression inflammatory mediators cyclooxygenase nuclear factor kappa nox conclusions akba protects skin cells uva induced damage modulating inflammatory mediators ros production therefore akba potential development skin care products karger basel
parkinson disease insidious onset neurodegenerative disease affecting approximately population age far available therapies aimed improving alleviating symptoms slowing preventing reversing course recently studies indicated levels activation abelson non receptor tyrosine kinase abl abl regulated brain tissue patients demonstrated abl inhibitors could improve motor behavior prevent loss dopamine neurons inhibit phosphorylation cdk regulate alpha synuclein phosphorylation clearance inhibit tyrosine phosphorylation parkin decrease parkin substrate example paris zinc finger protein aimp aminoacyl trna synthetase interacting multifunctional protein type fbp fuse binding protein synphilin therefore review mechanism abl inhibitor conclude abl inhibitors may potential treatment neurodegenerative disease
green energy saving building inevitable trend sustainable development construction industry green building evaluation standard system green building development important role paper chinese version green building evaluation criteria
surface development origins cloth making computer graphics without consideration thickness involving nonlinear optimization constraints moreover research surface development mainly focuses planar development paper development non developable sheet planar singly curved doubly curved surface patterns investigated optimal developing algorithm formulated minimize strain energy required deformation sheet orthogonal curvilinear coordinate system used three target patterns simplify constraints developing process resulting unconstrained quadratic optimization shell element solid element utilized finite element analysis similar developed results obtained planar spherical patterns using two types elements cylindrical pattern solid element model gives accurate result due contribution shell element translation rotational freedom elsevier ltd rights reserved
objectivesto evaluate whether low testosterone levels obesity directly associated tumor stage grade patients clinically localized prostate cancer methodspreoperative androgen serum levels total free testosterone sex hormone binding globulin body mass index waist circumference assessed consecutive european caucasian men treated radical prostatectomy hormone levels body mass index waist circumference correlated patient tumor specific characteristics using multivariable logistic regression analysis resultseven though confirmed inverse correlation bodyweight testosterone levels overweight low testosterone associated advanced disease poor differentiation prostate cancer using multivariate analyses body mass index waist circumference associated high grade disease gleason score waist circumference also correlated significantly lymph node metastasis conclusionsthis first study showing obesity low serum testosterone levels significantly associated high grade metastatic disease men diagnosed clinically localized prostate cancer present findings suggest low androgen levels diagnosis used held responsible development aggressive prostate cancer epiphenomenon obesity rather cause prostate cancer development progression
consider algorithm constructing asymptotic solutions regularized sense lomov see show problems reduced integro differential equations inverse time contrast known papers devoted topic see example paper study fundamentally new case characterized absence differential part linear operator isolates asymptotics solution constituents described boundary functions fact integral operator kernel diagonal degeneration high order furthermore spectrum regularization operator see may contain purely imaginary eigenvalues causes difficulties application methods construction asymptotic solutions proposed monograph based analysis principal term asymptotics isolate class inhomogeneities initial data exact solution original problem tends limit solution epsilon entire time interval consideration also including boundary layer zone solve called initialization problem paper theoretical nature designed lead greater understanding problems theory singular perturbations may applications various applied areas models described integro differential equations used example elasticity theory theory electrical circuits
acute mechanical damage resulting joint contact abnormalities central initiation progression posttraumatic osteoarthritis ptoa study ptoa typically performed vivo replicate animals using artificially induced injury features goal work measure changes joint contact stress knee large quadruped creation clinically realistic overload injury focal cartilage defect whole joint overload achieved excising wedge anterior medial meniscus focal cartilage defects created using custom pneumatic impact gun specifically developed mechanically characterized work evaluate effect injuries joint contact mechanics tekscan tekscan inc south boston measurements obtained pre operatively postmeniscectomy postimpact nonrandomized group axially loaded cadaveric sheep knees postmeniscectomy peak contact stress medial compartment increased contact area decreased center pressure cop shifted toward cruciate ligaments medial lateral compartments creation cartilage defect significantly change aspect contact mechanics measured meniscectomized knee work characterizes mechanical environment present quadrupedal animal knee joint two methods reproducibly induce joint injury features lead ptoa
due increasing complexity surgical working environment increasingly technical solutions must found help relieve surgeon objective supported structured storage concept relevant device data work present concept prototype development storage system address intraoperative medical data requirements system described solutions data transfer processing storage presented subsequent study prototype based presented concept tested correct complete data transmission storage ability record complete neurosurgical intervention low processing latencies final section several applications presented data recorder shown developed system based presented concept able store generated data correctly completely quickly enough even much data expected sent surgical intervention surgical data recorder supports automatic recognition interventional situation providing centralized data storage access interface communication bus future data acquisition technologies integrated therefore additional interfaces must developed data generated devices technologies also stored referenced surgical data recorder support analysis situation
purpose actual costs frequently deviate estimated costs either favorable adverse direction construction projects conventional cost evaluation methods take uncertainty correlation effects account regard simulation based cost risk analysis model correlated cost risk analysis model previously proposed evaluate uncertainty effect construction costs case correlated costs correlated risk factors purpose paper introduce detailed evaluation cost risk analysis model scenario sensitivity analyses design methodology approach evaluation process consists three scenarios three sensitivity analyses simulations total applications model important parameter called mean proportion coefficient modified user dependent variables like risk factor influence degrees changed observe response model modifications examine indirect two sided qualitative correlation capturing algorithm model monte carlo simulation also applied data compare results findings findings shown correlated cost risk analysis model capable capturing correlation costs risk factors operates accordance theoretical expectancies originality value correlated cost risk analysis model preferred reliable practical method professionals construction sector thanks detailed evaluation introduced paper
work inas based gate around gaa arch shaped tunneling field effect transistor tfet designed analyzed using technology computer aided design tcad simulations progress characteristics gaa arch shaped tfet inas highly attractive iii compound material adopted channel material owing gaa arch shaped structure tfet tunneling region gate area extended state current subthreshold swing improved however performance limitations related height source region source epitaxially grown thickness channel epi thus performed design optimization inas based gaa arch shaped tfet variables source epi optimization process characteristics gate capacitance transconductance cutoff frequency maximum oscillation frequency max extracted analyzed small signal modeling finally designed inas based gaa arch shaped tfet demonstrated dec thz max thz
background pityriasis versicolor superficial cutaneous fungal infection caused malassezia furfur dimorphic fungus study undertaken know various clinical patterns disease culture study vitro susceptibilities malassezia species various antifungals materials methods cross sectional study patients pityriasis versicolor evaluated clinically tertiary care hospital puducherry study period years history clinical examination done scraping samples sent microbiology department culture sensitivity data recorded accordingly results majority patients young males patients asymptomatic hypopigmented macules face neck patients use synthetic clothing shown exacerbation summer months recurrence rare majority patients show mild moderate scaling seborrheic dermatitis acne vulgaris common associated dermatoses majority koh woods lamp positive sixty seven patients culture positive patients show furfur colonies patients sensitive three common antifungals conclusion overall study shows furfur common isolated species sensitive three commonly used antifungals fluconazole itraconazole ketoconazole hence malassezia species developed resistance drugs study area used successfully treatment pityriasis versicolor
gender important variable study mental health actual perceived differences men women relatively little known males females differ manifestations antisocial personality disorder aspd demographic clinical features participants aspd assessed recorded women fewer episodes antisocial behavior involving involving police higher scores childhood trauma questionnaire ctq emotional abuse sexual abuse subscales ctq compared men ctq scores positively correlated number episodes antisocial behavior involving police men women percentage patients comorbid borderline histrionic personality disorders higher percentage participants cocaine use disorder lower among women compared men comorbid alcohol use disorder frequent groups higher percentage women comorbid mood disorders compared men logistic regression analysis demonstrates ctq scores histrionic personality disorder antisocial behavior involving police drive difference groups findings indicate treatment individuals aspd focus management comorbid psychiatric disorders published elsevier ireland ltd
aim analysis assess self reported chemotherapy induced peripheral neuropathy cipn symptoms association sociodemographic clinical characteristics treatment dose modifications influence magnitude neurotoxicity population based cohort patients multiple myeloma patients diagnosed filled eortc qlq cipn response data treatment outcomes dose modifications extracted medical files fifty three percent patients reported least one average three neuropathy symptoms bothered past week tingling toes feet reported multivariate analysis thalidomide especially higher cumulative dose associated neuropathy beta cipn associated age sex time since last course therapy number prior therapies osteoarthritis diabetes dose modifications often applied although statistically significant trend towards higher sensory motor neuropathy scores observed among patients receiving dose modification cipn compared receiving dose modification another reason dose modification without altering treatment response cipn common dose limiting side effect patients severity cipn mainly affected treatment thalidomide spite dose modifications patients still reported somewhat higher neuropathy scores without altered response rates early dose modification based reliable tool cipn measurements may prove value
continuity interpolation crucial topics computer graphics since beginnings every time want interpolate values across area need take set samples interpolating region however interpolating samples faithfully allowing results closely match underlying functions tricky task functions sample could smooth worst case could even impossible continuous situations bringing required continuity easy task much work done solve problem paper focus state art continuity interpolation three stages real time rendering pipeline study problems current solutions texture space object space screen space review literature areas hope bring new light foster research fundamental yet completely solved problems computer graphics
background human plasma derived nanofiltered esterase inhibitor inh used treat acute angioedema attacks patients hereditary angioedema hae data regarding use children sparse methods patients diagnosis hae type recruited multicenter open label trial patients recruited weight categories weight category included dosing levels inh units inh respectively patients experiencing angioedema attack given single intravenous dose primary efficacy end point onset unequivocal relief defining symptom within following initiation inh treatment results nine children treated received received received lower weight higher dose category successfully enrolled patients completed study angioedema attacks abdominal patients met primary end point median time unequivocal symptom relief range doses inh ranged conclusions treatment single angioedema attack inh doses patients patients well tolerated doses inh may appropriate pediatric patients
chitosan materials prepared different sources fishery waste subsequently characterized influence molecular weight degree deacetylation dda chitosan acetic acid solution viscosity studied prepared chitosan found influence viscosity solution increase increases viscosity chitosan acetic acid solution dda found influence viscosity chitosan acetic solutions chitosan solutions varying concentrations viscosities used produce chitosan membranes phase inversion technique followed cross linking membranes using glutaraldehyde chitosan content membranes found mol characterisation results indicated membranes could visualised consisting hydrated polymeric network chitosan forms rigid honeycomb structure moisture present membrane found present fixed water integrated chitosan enabled use pressure driving force removal moisture membrane free water content subsequently found equal porosity membrane namely total water membrane water characterised fixed water membrane wet density pore radius specific surface area determined respectively subsequently chitosan membranes found analogous transport behaviour ultrafiltration membranes pure water flux membranes found order bar transport solutes solvent could modelled sufficiently low solute concentrations using generic membrane model derived irreversible thermodynamics elsevier rights reserved
aim study investigate consultant genitourinary physicians health advisers views regarding acceptability patient delivered partner therapy pdpt united kingdom postal questionnaire sent consultant physicians senior health advisers physician questionnaires health adviser questionnaires returned one hundred three physicians health advisers reported ever used pdpt approximately one third professionals strongly opposed pdpt however majority professional groups cautiously prepared consider pdpt option health professional first makes contact partner chief concern among health professionals legal status pdpt current general medical council gmc guidance remote prescribing helpful outcome medical research council randomized controlled trial accelerated partner therapy fits gmc guidance eagerly awaited professionals would welcome evidence based national guidance
primary progressive aphasia ppa heterogeneous neurodegenerative condition prominent clinical feature language difficulties cognitive domains described remain unaffected early stages disease therefore excluded diagnostic criteria however show article executive function disorders may present variants nonfluent agrammatic logopenic semantic ppa also illustrate changes language means year behavioral neuroimaging longitudinal study patient suffering semantic variant ppa review provides update current knowledge ppa suggesting dysexecutive symptoms may encountered ppa variants early phases advanced stages atrophy extends adjacent brain areas
syndrome inappropriate antidiuretic hormone siadh reported common cause hyponatraemia retrospective cross sectional study evaluated diagnosis siadh hospitalised patients australian tertiary hospital reference recently published clinical guidelines investigation siadh incomplete cases adrenal insufficiency hypothyroidism excluded significant number cases
advertising form business promotion widely different applications lighting lamps one key equipments entire outdoor advertising facilities order improve advertising effectiveness facilities security especially outdoor advertising lighting applications remote areas occasionally occur advertising lamps stolen damaged novel advertising lighting anti thefts security system based digital control technologies designed implementation paper designed system achieve real time online status monitoring advertising lighting lamps abnormal situation system issued site sound light alarms remote line notification etc greatly improving anti theft security performance outdoor advertising lighting
rapidly changing demographics united states workforce include large number women members minority groups currently underrepresented science engineering related education careers recent research indicates singular incidents sexism exist gender bias often affects women various subtle ways effects stereotype threat lack appropriatementoring female role models samples possible factors contributing performance longevity women math intensive fields address issue affects radiation protection current status women field reviewed progression scientific pipeline education employment positions scientific bodies professional recognition primary focus american women institutions racial diversity demographics reviewedwhere available findings indicate women minority racial groups underrepresented multiple aspects education research leadership gender diversity across field yet reached gender parity trending indicates percentage women earning degrees radiation protection consistently increased last four decades diversity racial groups however remained fairly consistent well national averages diverse perspectives documented collective problem solving lead innovative solutions
background although serum adiponectin level inversely correlated body mass index closely associated obesity related diseases neither impact weight loss adiponectin level factors might influence adiponectin level weight loss intervention well documented objective objective study assess change serum adiponectin level weight loss intervention determine sleep parameters affect serum adiponectin level methods ninety women overweight obesity aged years completed month cognitive behavioural therapy based weight loss intervention included dieting exercise stress management serum adiponectin level body fat percent symptoms depression anxiety objective sleep parameters assessed actigraphy measured baseline end intervention results serum adiponectin level significantly increased weight loss intervention multiple regression analysis change adiponectin level positively associated magnitude body fat loss beta increase sleep minutes beta conclusion increase objective sleep duration related significantly increased serum adiponectin level independently change body fat weight loss intervention
mixed payment systems become prominent alternative paying physicians fee service capitation theory shows mixed payment systems superior causal effects physicians behavior introducing mixed systems well understood empirically systematically analyze influence fee service capitation mixed payment systems physicians service provision controlled laboratory setting implement exogenous variation payment method medical non medical students role physicians lab choose quantities medical services affecting patients health outside lab behavioral data reveal significant overprovision medical services fee service significant underprovision capitation although less predicted assuming profit maximization introducing mixed payment systems significantly reduces deviations patient optimal treatment although medical students tend patient regarding results hold medical non medical students responses incentive systems explained behavioral model capturing individual altruism particular find support altruism plays role service provision partially mitigate agency problems altruism heterogeneous population copyright john wiley sons ltd
background understanding exact nature executive function deficits conduct disorder remains elusive issues morbidity attention deficit hyperactivity disorder adhd method seventy two adolescents adhd healthy controls hcs assessed computerized battery putative cool hot efs participants also completed child behaviour checklist cbcl results cool tasks planning adhd group particular showed notable impairments compared hcs pattern less evident set shifting behavioural inhibition significant correlations errors scores tasks indices externalizing behaviours cbcl across sample hot tasks clinical groups performed worse hcs delay gratification poor performance correlated externalizing scores although notable group differences punishment based card playing task significant correlations ultimate payout externalizing behaviour across groups conclusions overall findings highlight fact may common distinguishing neuropsychological underpinnings morbid disorders dimensional symptom based approach may way forward
unsteady state gas dynamics intake turbocharged engine analysed objective tune intake line low operating speeds exhaust gases lack enthalpy needed operate turbocharger rated speeds provide boost pressure needed proposed methodology compensates lack boost pressure benefiting existing wave action intake zero dimensional acoustic modelling first used investigate geometrical parameters influnce low end acoustic tuning impedance bench electrically driven engine tests complete study compare different intake configurations two geometries charge air coolers air air charge air cooler water cooled charge air cooler optimal intake configurations found low end torque considerations well high speed operation reduction pressure losses important findings validated established engine test bench torque gain different rotational speeds engine study led proposal active charge air duct enables solution found low end torque acoustic tuning favoured high speed operation boost pressure readily available acoustic response part compared reference solution conclusions possible topics future work obtained analysis
entanglement entropy correlates two quantum subsystems part larger system logarithmic divergence term present entanglement entropy universal nature directly proportional conformal anomaly study logarithmic divergence term entropy massive scalar field dimensions applying numerical techniques entanglement entropy approach dimensional massive theory obtained dimensional massless scalar field via dimensional reduction also calculated mass corrections entanglement entropy scalar field finally observe area law contribution entanglement entropy affected mass term universal quantities depend upon basic properties system
reported digital thermionic emission current controllers use floating voltage sources produce noise current consequently decrease quality electron beam implementation digital control electron source biasing system without floating sources gives average value electron emission current standard deviation described controller developed order investigate properties new hot emitters
aim study examine whether compulsive exercise mediates relationship clinical perfectionism eating pathology based cognitive behavioral model compulsive exercise participants adults participated regularly sport exercise completed online measures perfectionism compulsive exercise eating disorders support well established link perfectionism eating disorders clinical perfectionism predicted eating pathology directly indirectly mediated compulsive exercise addition also direct effects clinical perfectionism avoidance rule driven behavior weight control mood improvement subscales compulsive exercise test cet direct effect cet weight control subscale eating pathology negative direct effect cet sub scale mood improvement eating pathology findings lend support cognitive behavioral model compulsive exercise clinical perfectionism conceptualized related eating disorders directly indirectly mediation compulsive exercise compulsive exercise also found direct effect eating disorders compulsive exercise may symptom eating pathology rather antecedent however causal inferences could established given correlational design longitudinal research using cross lagged panel designs examine bidirectional relationship compulsive exercise eating disorders needed elsevier ltd rights reserved
idiopathic pulmonary fibrosis ipf characterized aberrant deposition extracellular matrix ecm constituents including glycosaminoglycans gags may play role remodelling processes influencing critical mediators growth factors hypothesize gags may altered ipf contribute create pro fibrotic environment aim study therefore examine fine structure heparan sulfate chondroitin dermatan sulfate hyaluronan lung samples ipf patients control subjects gags lung samples severe ipf patients donor lungs analyzed hplc assessed immunohistochemistry collagen quantified hydroxyproline content total amount increased ipf lungs significant difference total collagen content found relative increase total sulfation due increment sulfation higher proportion sulfation highly sulfated located border zone denser areas normal looking alveolar parenchyma basement membranes blood vessels airways immuno positive perlecan well cell surface spindle shaped cells alveolar interstitium findings show first time amount structure glycosaminoglycans altered ipf changes may contribute tissue remodelling ipf altering growth factor retention activity creating pro fibrotic ecm landscape authors published elsevier ltd
present method robust input design nonlinear state space models method optimizes scalar cost function fisher information matrix set marginal distributions stationary processes using elements graph theory characterize set since true system unknown resulting optimization problem takes uncertainty true value parameters account addition required estimates information matrix computed using particle methods resulting problem convex decision variables numerical examples illustrate proposed technique identifying models using expectation maximization algorithm elsevier ltd rights reserved
polygon retrieval problem essence problem preprocessing set dimensional points given special containedin spatial query subset points falling inside polygon reported efficiently queries find great applicability areas computer graphics spatial databases gis applications however size spatial data grows rapidly existing centralized solutions fail retrieve results reasonable response time paper propose novel mapreduce algorithm efficiently processing convex polygon planar range queries distributed manner apply grid based angle based partitioning scheme data space perform comparative analysis experimental evaluation prove system efficient robust scalable
growing interest pharmaceutical field concerning isoflavones topical delivery systems especially regard skin care properties antiherpetic activity context present work describes ultra fast liquid chromatography method uflc determining daidzein glycitein genistein different matrices development topical systems containing isoflavone aglycones obtained soybeans method showed specific precise accurate linear determination soybean acid extract rich fraction obtained purification process loaded nanoemulsions topical hydrogel well permeation retention assays porcine skin porcine esophageal mucosa matrix effect determined complex matrices demonstrating low effect analysis stability indicating uflc method verified submitting acidic alkaline oxidative thermal stress conditions interference degradation products detected analysis mass spectrometry performed show main compounds produced acid hydrolysis soybeans well suggest main degradation products formed stress conditions besides hydroxymethylfurfural ethoxymethylfurfural produced identified acid hydrolysis soybean extract well separated uflc method method robustness confirmed using plackett burman experimental design therefore new method affords fast analysis routine processes extract purification products development bioanalytical assays elsevier rights reserved
maximal ball algorithm well established method morphological analysis porous media extracts network pores throats volumetric data paper describes structural modifications algorithm basic concepts preserved substantial improvements accuracy efficiency achieved follows first calculations performed subvoxel accurate distance field approximations discretize balls made second data structures simplified keep memory usage low improve algorithmic speed third small reasonable adjustments increase speed significantly volumes high porosity memory usage improved compared classic algorithms furthermore processing accelerated three times finally modified algorithm verified extracting several network properties reference well real data sets runtimes measured compared literature
surface soil moisture ssm important parameter land atmosphere interface past decades passive microwave remote sensing offers good opportunity obtaining ssm global scale many downscaling methods proposed using triangle based empirical soil moisture relationship models overcome limitation coarse spatial resolution ssm products regional applications paper aimed examine compare effectiveness five typical triangle based empirical soil moisture relationship models estimating ssm landsat data situ measurements maqu network northeastern part tibetan plateau nine cloud free days results showed model treats ssm second order polynomial land surface temperature vegetation indices vis surface albedo inputs exhibited best performance compared results models comparison indicated use normalized difference fractional vegetation cover model outperformed vis root mean square deviation approximately coefficient determination nine day average level addition significant spatial scale effect model also found analyzing model fitting results different window sizes study provides important insight best empirical relationship models capturing soil moisture dynamics models support passive microwave soil moisture data spatial downscaling validation applications future studies
impaired dual tasking namely inability concurrently perform cognitive motor task stops walking talking largely unexplained frequent symptom parkinson disease consider two circuit level accounts striatal dopamine depletion might lead impaired dual tasking patients parkinson disease first loss segregation striatal territories induced dopamine depletion may lead dysfunctional overlaps motor cognitive processes usually implemented parallel cortico striatal circuits second known dorso posterior ventro anterior gradient dopamine depletion patients parkinson disease may cause funnelling motor cognitive processes relatively spared ventro anterior putamen causing neural bottleneck using functional magnetic resonance imaging measured brain activity patients parkinson disease control subjects performance motor task auditory cued ankle movements cognitive task implementing switch stay rule tasks simultaneously dual task distribution task related activity respected known segregation motor cognitive territories putamen groups motor related responses dorso posterior putamen task switch related responses ventro anterior putamen dual task performance patients made motor cognitive errors control subjects recruited striatal territory ventro posterior putamen engaged either cognitive motor task used controls relatively higher ventro posterior putamen activity controls associated worse dual task performance observations suggest dual task impairments parkinson disease related reduced spatial focusing striatal activity pattern striatal activity may explained loss functional segregation neighbouring striatal territories occurs specifically dual task context
scenarios used tools development smart home platforms middleware aging place order effective set scenarios address required functionalities needed health condition majority aging population described medical tools international classification functioning disability health icf local health profiles however yet fully implemented development smart homes study develop public health methodology phm use public health resources generation scenarios specific user characteristics taken medical tools common daily user activities supplied research common activities practiced dutch end users functional scenario generated combining user characteristics user activities product goal physical non physical environment product developed using method set scenarios covered requirements scenarios used virtual tests validation smart home platforms phm promising tool development smart environments easily adopted aging populations
using hydrogen engine supplementary fuel effective way improve engine performance taking hydrogen supplementary fuel dual fuel injection system hydrogen gasoline combined injection gasoline port injection hydrogen direct injection proposed cold start characteristics dual fuel engine studied experimentally study performed three injection modes included pure gasoline port injection pure hydrogen direct injection hydrogen gasoline combined injection test results showed hydrogen addition improved ignition reliability advanced occurrence first effective firing cycle combined injection mode larger adaptive range ignition timing cold start period optimum ignition timing maximum cylinder pressure advanced higher flame propagation speed hydrogen comparing three injection modes combustion emissions performance hydrogen gasoline combined injection superior pure gasoline port injection emission emission reduced case combined fuel injection respectively however enhanced cylinder temperature nox emissions increased hydrogen addition elsevier ltd rights reserved
resistance distance two vertices connected graph defined effective resistance electrical network constructed graph replacing edge unit resistor kirchhoff index graph defined sum resistance distances pair vertices graph let generalised join graph determined paper first give formulae resistance distances kirchhoff index terms parameters show computing resistance distances kirchhoff index decomposed simpler ones finally obtain explicit formulae resistance distances kirchhoff index take special graphs complete graph path cycle
psoriasis atopic dermatitis common chronic inflammatory skin diseases discuss several aspects disorders including risk factors incidence prevalence complex disease burden comorbidities increase clinical significance disorder also focus treatment management strategies outline individualized patient centered treatment regimens part care plans patients either psoriasis atopic dermatitis finally conclude theoretical knowledge optimum care plans patients increasingly sophisticated understanding unfortunately always reflected daily clinical practice
vector instructions modern cpus crucially important performance compute intensive algorithms auto vectorisation often fails unfortunate choice data layout programmer paper proposes data layout inference auto vectorisation identifies layout transformations convert single instruction multiple data unfavourable layouts data structures favourable ones present type system layout transformations sketch inference algorithm finally present initial performance figures impact inferred layout transformations show non intuitive layouts inferred system vast performance impact compute intensive programs copyright john wiley sons ltd
background aim narrowband uvb uvb treatment commonly used management psoriasis atopic dermatitis less often used vitiligo children aim study evaluate efficacy short term safety uvb phototherapy children diagnosed vitiligo retrospectively materials methods total patients younger years diagnosis vitiligo managed uvb phototherapy documented archive records evaluated clinical response assessed according repigmentation lesions good response repigmentation moderate response repigmentation poor response repigmentation less unresponsive pigmentation new lesions occurred results total patients received uvb treatment girls boys age onset disease varied years mean age onset years repigmentation rate detected cases conclusion uvb phototherapy seems well tolerated effective safe treatment option children especially unresponsive topical treatment widespread lesions however long term risks photocarcinogenesis photoaging kept mind
background diagnosed cancer causes major psychological distress yet majority newly diagnosed cancer patients lack psychological support internet interventions overcome many barriers seeking face face support allow independence time place assess efficacy feasibility first web based stress management intervention stream stress aktiv mindern newly diagnosed german speaking cancer patients methods design prospective wait list controlled trial newly diagnosed cancer patients included within weeks starting anti cancer treatment randomized immediate intervention group delayed control group week web based intervention intervention consists eight modules weekly written feedback psychologist minimal contact based well established stress management manuals including downloadable audio files exercises aim study evaluate efficacy terms improvement quality life fact well decrease anxiety depression hads compared patients wait list control group sample size patients allows demonstrating clinically relevant difference nine points fact score intervention two sided alpha power first online stress management intervention german speaking cancer patients descriptive outcomes equally important refine group patients largest potential benefit targeted specifically future trials descriptive endpoints include patients characteristics type cancer type treatment socio demographic factors dropout rate dropout reasons adherence satisfaction program discussion new technologies open new opportunities minimal contact psychological interventions becoming standard care several psychological disorders efficacy often comparable face face interventions study open field population newly diagnosed cancer patients assess clinical efficacy also refine target population potential benefit internet based minimal contact stress management program might attractive time cost effective way effectively deliver psychological support newly diagnosed cancer patients opportunity include currently reached conventional support
paper investigates self organized critical approach dynamically load balancing computational workloads proposed model based bak tang wiesenfeld sandpile cellular automaton works critical regime edge chaos analogy grains sand tasks arrive pile different processing elements sites system pile exceeds certain threshold collapses initiates avalanche migrating tasks producing load balancing show frequency avalanches power law relation sizes scale invariant fingerprint self organized criticality emerges without tuning parameters emergent pattern organic properties self organization tasks resources self optimization computing performance conducted experimentation also reveals system critical attractor point arrival rate tasks equals processing power system taking advantage fact hypothesize processing elements turned depending state workload maximize utilization resources interesting side effect overall energy consumption system minimized without compromising quality service
feedback use submerged structures beach protection still scarce shoreline response structures still poorly understood present studies presents structures close shoreline without significant morphologies shoreface could interact lido sete narrow coastal barrier facing mediterranean sea experimentation beach protection using submerged geotextile structure undertaken structure deployed analyse nearshore dynamics argus video system installed video derived shoreline bar crest position alongshore currents swash processes used assess natural dynamics evaluate evolution installation long structure monitoring permitted describe rapid dynamics crescentic nearshore bars processes longshore migration linearization well strong coupling bar dynamics shoreline sinuosities described deployment geotextile progressive linearization rotation nearshore bar parallel tube observed process induced progressive rotation shoreline important beach enlargement patterns bar emerged beach progressively disappeared new beach morphology storm run regular alongshore major events reach dune front generate impacts field experiment provide interesting feedback morphological response following deployment submerged structure shoreface characterized important nearshore bar dynamics
background human polyomavirus hpyv hpyv shed chronically human skin hpyv hpyv linked pruritic skin eruption immunosuppression objective determined whether biopsy specimens showing characteristic pattern dyskeratosis parakeratosis might associated polyomavirus infection methods screened biopsy specimens showing peacock plumage histology polymerase chain reaction hpyvs cases positive hpyv hpyv analyzed immunohistochemistry electron microscopy immunofluorescence quantitative polymerase chain reaction complete sequencing including unbiased next generation sequencing results identified additional cases hpyv hpyv skin infections expression antigen viral capsid abundant lesional skin dual immunofluorescence staining experiments confirmed hpyv primarily infects keratinocytes high viral loads lesional skin compared normal appearing skin identification intact virions electron microscopy next generation sequencing support role active viral infections skin diseases limitation small case series archived materials conclusion found hpyv hpyv associated rare pruritic skin eruptions distinctive histologic pattern describe entity hpyv hpyv associated pruritic dyskeratotic dermatoses
industry factories around world grow automated intelligent smart camera plays important role smart camera equipped processor memory communication interface operating system process large amounts data advance assist follow automatic inspection judgment additionally since smart camera independent system affect original system factories immense advantage troubleshooting besides thanks technology breakthroughs recent years using graphics processing unit gpu implementing tons parallel computing helps significantly boost overall efficiency therefore rising number factories consider improving production capacity production lines use gpu assist improvement important issue based scenario paper used nvidia tegra platform gpu cuda cores quad core arm cortex processor basler usb industrial camera simulate smart industrial camera gpu perform myriad complex computations paper designed recognize count objects real time manner highspeed industrial inspection environment large volumes data verify concept smart camera gpu cores proposed experimental results proved ideas software design architecture provided paper simple efficient design future application internet things internet everything structure valuable reference
several samples residual base course material studied investigate effects compaction physical mechanical properties test results compaction cbr obtained borrow pit material compared repeatedly used soil samples road analysis changes strength materials construction also site observations recommended establish minimum requirements compaction density also maximum density guidelines discussed control level compaction site
pitch surge coupled dynamic model high speed craft available dynamic trim control applications literature existing fluid structure interaction models high speed craft adequate simulations control applications since require great deal computation time example depending vessel particulars hence work aimed obtain dynamic model high speed craft surge pitch motions obtained model utilized design automatic controller adjust command signal high speed craft increase fuel efficiency safety comfort passengers vessel coupled pitch surge motion high speed craft trim tabs interceptors modelled using full scale sea trial data linear parametric modelling using system identification methods artificial neural network ann modelling carried comparisons training validation results given high correlation coefficients low average values absolute errors surge pitch dynamics obtained using ann method ann model improved control designs marine vessel operations
franco regime spain banned contraceptive methods pill started circulating spain officially drug used gynaecological therapy however following decade also increasingly used prescribed contraceptive paper analyses debates contraceptive pill spanish daily newspaper abc two magazines blanco negro triunfo concludes debate contraceptive method much heterogeneous might expected given catholic conservative character dictatorship daily press focused adverse effects drug magazines concentrated ethical religious aspects pill discussed generally positive light male doctors catholic authors dominated debate
airborne wind turbines awts represent radically new fascinating concept future harnessing wind power concept consists realizing blades conventional wind turbine cwt form power kite flying high speed perpendicular wind kite mounted turbine electrical generator power electronics converter electric power generated transmitted via medium voltage cable ground high flight speed power kite several times actual wind speed small swept area turbine required according betz law turbine low weight generation given electric power moreover high turbine rotational speed gear transmission necessary size generator also reduced takeoff landing power kite turbines act propellers generators motors electric power supplied system maneuvered like helicopter present work configuration power electronics converters implementation awt considered major aspect trade power weight ratio efficiency dependence cable weight cable losses voltage level power transmission investigated comparison made low voltage medium voltage versions generators furthermore interdependence weight efficiency bidirectional dual active bridge converter coupling rectified output voltage generator cable discussed basis discussion concept offering best possible compromise weight efficiency power electronics system selected model control behavior derived power flow directions control structure proposed dimensioned furthermore questions electromagnetic compatibility electrical safety treated conclusion essential results paper summarized outlook future research given enable reader make simplified calculations comparison cwt awt aerodynamic fundamentals systems summarized highly simplified form appendix numerical values given system discussed paper
paper analyzes perceived dissimilarity postures humanoid robots first human perception absolute distance postures focused shown results derived computer graphics human figures replicated humanoids despite difference body proportions arrangement degrees freedom successively perception relative distances postures considered shown paradoxically better prediction distance pair postures necessary lead better predictions multiple distances shortest finally paper concludes briefly discussing possible implications finding fields motion retrieval motion blending
understanding role inherited cancer predisposition syndromes pediatric tumor diagnoses continues develop information learned application genomic technology identifying patients relatives increased risk developing cancer important step care patient population purpose review highlight various tumor types arise pediatric population cancer predisposition syndromes associated tumors review serves guide recognizing genes conditions consider pediatric cancer referral presents genetics clinic
work presents analysis two quadrant regulator connected link quadrant magnet supply key objective present regulation strategies controlling peak power required power network well recover magnet energy capacitor banks comparative study highlights trade size reactive elements peak current drawn electrical network presented
aim article describe nonverbal communication patterns passengers delhi metro use manage density induced territorial intrusions identify contextual variables affect deployment introducing notion interrogative look dataset following section depicts techniques passengers observed employ order solve problem territorial intrusion without breaking anonymity bulk analysis deals structure function interrogative looks objectively defined pattern nonverbal behavior touched uses signal discontent toucher rest section describes less frequent pattern whereby passengers contagiously signal playful character mischiefs next examined density number individuals per surface unit influences contextual variable occurrence interrogative looks closing discussion considers main findings standpoint local specificity
frontotemporal lobar degeneration ftld encompasses certain related neurodegenerative disorders alter behaviour personality language heterogeneous ribonuclear proteins hnrnps maintain rna metabolism changes function may underpin pathogenesis ftld immunostaining hnrnp performed sections temporal cortex hippocampus patients ftld stratified pathological hallmarks ftld tau ftld tdp type subtypes genetics patients corf expansions mapt grn mutations without known mutation four patients motor neurone disease mnd corf expansions healthy controls also studied semi quantitative analysis assessed hnrnp staining intensity dentate gyrus region hippocampus temporal cortex tcx different pathological genetic groups immunostaining hnrnp revealed consistent changes pattern amount physiological staining across pathological genetic groups immunostaining inclusions resembling tdp immunoreactive neuronal cytoplasmic inclusions dystrophic neurites seen either tcx hippocampus ftld cases investigated hnrnp however immunostaining hnrnp showed inclusion bodies resembling tdp negative immunopositive structures containing dipeptide repeat proteins dpr variably observed hippocampus cerebellum proportion cases showing hnrnp immunoreactive dpr number hnrnp positive inclusions within cases significantly greater cells region cerebellum latter significantly less three regions compared detected immunostaining
progressive role computers users actors social networks computations alike social network analysis sna gaining attention work proposes approach based sna alone social networks supported existing approaches estimate tourists satisfaction individual points interest pois accordingly recommend pois tourist tour planning system moreover instead common unimodal network bimodal tourist reviewer network modeled suggested sna literature given tourists poi reviewers act two distinct classes entities links representing dis similarities tourists reviewers provide personal attributes like age reviewers providing preferences specific pois whereas tourists preferences certain types categories pois say archeology algorithm grouping islands similar reviewers certain tourist given strength corresponding links bimodal network developed additionally ranking algorithm based degree authority centrality adopted identify highest ranked reviewers within island recommend preferred pois given tourist single pois preferred per reviewer remain requested pois highly ranked reviewers select among recommendation similar centrality algorithm applied reviewer poi network links representing certain reviewer prefers certain poi evaluation initially exemplary real life experiment extended massive online dataset foursquare proves approach feasible estimating tourist satisfaction individual pois moreover already promising since incorporating location influence remains yet future work might improve performance
individual differences preference group based hierarchy inequality indexed social dominance orientation sdo shown predict environment relevant variables date literature examining sdo environmentalism link used traditional unidimensional conceptualisation sdo article reports three studies using new measurement conceptualisation sdo involves sdo scale sub dimensions intergroup dominance sdo intergroup anti egalitarianism sdo sdo entails support group based dominance achieved via overt oppression aggressive intergroup behaviour sdo entails support group based inequality subtly achieved via unequal distribution resources results show anti egalitarianism main sdo sub dimension related environmentalism sdo either weaker non significant predictor individuals high levels sdo less willing make personal sacrifices environment value environmental protection endorse climate change beliefs interestingly neither facet sdo predicted change environmentalism five month period climate change denial predicted change sdo pro environmental attitudes predicted change sdo time elsevier ltd rights reserved
diesel engines widely used due high reliability high thermal efficiency fuel availability low consumption used generate power passenger cars ships power plants marine offshore platforms mining construction machines engine heart applications keeping good working condition vital recent technical computational advances environmental legislation stimulated development efficient robust techniques diagnostics diesel engines emphasis diagnostics faults development causes engine failure reduced efficiency diesel engine fuel injection plays important role development combustion engine cylinder arguably influential component diesel engine fuel injection equipment even minor faults cause major loss efficiency combustion increase engine emissions noise increased sophistication higher injection pressures required meet continuously improving noise exhaust smoke gaseous emission regulations fuel injection equipment becoming even susceptible failure injection systems shown largest contributing factor diesel engine failures extracting health information components fuel injection system demanding task besides time consuming nature experimental investigations direct measurements also limited selected observation points diesel engine faults normally occur short timeframe modeling typical engine faults particularly combustion related faults controlled manner thus vital development diesel engine diagnostics fault detection simulation models based physical grounds enlarge number studied variables also obtain better understanding localized phenomena affect overall behavior system paper presents survey analysis modeling diagnostics diesel fuel injection systems typical diesel fuel injection systems common faults presented relevant state art research articles analysis modeling fluid injection systems well diagnostics techniques measured signals describing behavior system reviewed results findings discussed increasing demand effect legislation related diagnostics especially board diagnostics obd discussed reference future progress field
objectives characterize comorbidities health related quality life hrqol productivity healthcare resource use adults atopic dermatitis relative without evaluate impact patient reported severity outcomes methods data national health wellness survey nhws collected self reported information demographics comorbidities hrqol health survey productivity work productivity impairment questionnaire wpai healthcare utilization weighted general population cohort consisted subjects reported experienced within past months non cohort included subjects report experiencing subjects self reported mild moderate severe disease univariable multivariable analyses compared characteristics outcomes cohorts severity levels results cohort younger non cohort years higher proportion females relative non cohort cohort significantly higher prevalence atopic conditions including nasal allergies asthma neuropsychiatric conditions anxiety depression units resource use healthcare practitioner visits emergency room hospitalizations higher hrqol poorer wpai employees reported almost twice much lost work productivity non employees clear differences outcomes observed among patient reported severity categories except greater impairment work productivity daily activities moderate severe relative mild conclusions significant burden associated relative without suggests unmet need effective management strategies also appears need characterization disease severity impact hrqol
many patients allergic disorders continue uncontrolled symptoms despite new better pharmacologic options novel biologic agents target specific critical pathophysiologic pathways developed better manage patients utility biologic agents management allergic diseases facilitated recent advances better characterizing patients including identification relevant biomarkers predict clinical responsiveness led ability phenotype endotype patients allowing rational approach picking specific biologic agent specific patient review focus point care biomarkers enhance usefulness biologics manage uncontrolled asthma urticaria nasal polyposis discuss biologic agents already approved management allergic respiratory disorders biologics currently development recently abandoned lack efficacy intolerable side effects successes failures biologics clinical trials facilitated ability better understand molecules pathways important pathogenesis allergic diseases development symptoms impairment individual patients
authors performed bilateral malar reconstruction using polyether ether ketone implants patients treachercollins syndrome absent opposed hypoplastic zygomata patient specific implants fabricated using computed aided design software reformatted three dimensional bony preoperative computed tomography images first time authors performed procedure implant compressed globe resulting temporary anisocoria quickly recognized intraoperatively implant immediately removed patient made full recovery ocular disturbance computer aided design manufacturing process adjusted include periorbital soft tissue boundaries aid contouring new implants patient patients subsequently underwent malar reconstruction using soft tissue periorbital boundary fabrication process additional relief removed implant orbital surface subsequent procedures performed without complication pleasing aesthetic results authors describe experience salutary lessons learnt
introduction influence personality traits suicidal behaviour risk well documented personality traits suicidal behaviour partially genetically determined personality described endophenotype suicidal behaviour aim study investigate possible association personality traits suicidal behaviour selected serotonergic gene polymorphisms methods study included patients meeting dsm criteria bipolar disorder healthy controls personality dimensions assessed using temperament character inventory tci genotyped two selected polymorphisms tryptophan hydroxylase tph gene polymorphism promoter region serotonin transporter gene httlpr related serotoninergic neurotransmission multiple poisson regression logistic regression kruskal wallis tests applied results found numerous differences patients control group terms tci dimensions subdimensions significant differences found patients without suicidal attempts fatigability asthenia well harm avoidance also found interactions tci subdimensions interaction disordiness spiritual acceptance disordiness integrated conscience extravagance resourcefulness significantly contributing suicidal behaviour risk found association studied genetic polymorphisms several tci dimensions subdimensions conclusion results confirm personality traits partially determined genes personality traits interactions temperament character traits may helpful predicting suicidal behaviour
although fiber well recognized effect laxation increasing evidence supports role fiber prevention treatment chronic disease aim review provide overview health benefits fiber fermentation describe products fermentation may influence disease risk treatment higher fiber intakes associated decreased risk cardiovascular disease type diabetes forms cancer fiber may also role lowering blood pressure preventing obesity limiting weight gain fiber effective managing blood glucose type diabetes useful weight loss may provide therapeutic adjunctive roles kidney liver disease addition higher fiber diets contraindicated inflammatory bowel disease irritable bowel syndrome may provide benefit common associations disease reduction fermentation fiber potential modulate microbiota activities inflammation specifically production anti inflammatory short chain fatty acids primarily saccharolytic fermentation versus deleterious products proteolytic activity fiber intake inversely associated cause mortality mechanisms fiber may reduce chronic disease risk provide therapeutic benefit chronic disease need elucidation large randomized controlled trials needed confirm causality teaching points strong evidence supports association higher fiber diets reduced risk cardiovascular disease type diabetes forms cancer higher fiber intakes associated lower body weight body mass index types fiber may facilitate weight loss fiber recommended adjunctive medical nutritional therapy type diabetes chronic kidney disease certain liver diseases fermentation resulting shifts microbiota composition activity may common means fiber impacts disease risk management
recent smartphone platforms based new operating systems ios android windows phone huge success recent years open many new opportunities unfortunately also showed new technologies privacy related data smartphones also increasingly interesting attackers especially android platform favorite target malware mainly openness platform ability install applications sources android market significant gains market share although processes detecting analyzing malware well known world arms race attackers defenders continued past years directly applied smartphone platforms differences hardware software architectures paper first give overview current malware situation smartphone platforms special focus android explain relevant malware detection analysis methods turns current malware relies installation user represents last line defense malware detection conclusions present new malware detection method focuses information user able see prior installation applicationthe metadata within platform software market depending platform includes application description permissions ratings information developer analyze data use sophisticated knowledge discovery processes lean statistical methods presenting wide range examples based real application metadata extracted android market show possibilities new method possibilities argue essential part complete malware analysis detection chain includes well known methods network traffic analysis static dynamic code inspection copyright john wiley sons ltd
introduction purpose resistance training ibuprofen supplementation may improve musculoskeletal health postmenopausal women study purpose determine efficacy resistance training ibuprofen supplementation bone muscle properties postmenopausal women methods participants randomly assigned supervised resistance training stretching placebo exercise postexercise ibuprofen placebo supplementation dwk months baseline postintervention measurements included distal shaft scans forearm lower leg using peripheral quantitative computed tomography distal site outcomes included cross sectional area content density total trabecular bone well estimated bone strength compression shaft site outcomes included total bone area cortical bone area content density estimated bone strength torsion muscle area density results exercise supplement time interactions total bone content distal radius cortical density radius shaft significant resistance training ibuprofen decreased total bone content distal radius comparison resistance training ibuprofen alone change cortical density radius shaft differed stretching placebo ibuprofen supplementation groups resistance training preserved muscle density lower leg stretching conclusions ibuprofen consumed immediately resistance training deleterious effect bone mineral content distal radius whereas resistance training ibuprofen supplementation individually prevented bone loss resistance training prevented muscle density decline lower leg
conventional clock drawing test ccdt rapid inexpensive screening tool detection moderate severe dementia however usage limited due poor diagnostic accuracy especially patients mild cognitive impairment mci diagnostic value newly developed digital clock drawing test dcdt evaluated compared ccdt patients early dementia due edat patients amnestic mci amci cognitively healthy controls hcs parameters assessed dcdt time transitioning stylus one stroke next surface time air time stylus produced visible stroke time surface total time clock drawing receiver operating characteristic roc curves calculated logistic regression analyses conducted statistical analysis using dcdt time air significantly increased edat compared amci addition time air significantly longer patients amci compared even amci group normal ccdt score time air using dcdt allowed discrimination patients amci hcs sensitivity specificity ccdt scoring revealed sensitivity specificity interestingly time air allowed even discrimination amci patients normal ccdt scores amci patients hcs clinically relevant sensitivity specificity combination dcdt variables ccdt scores improve discrimination patients amci conclusion assessment time inair using dcdt yielded higher diagnostic accuracy discrimination amci patients hcs use ccdt even amci patients normal ccdt scores modern digitizing devices offer opportunity measure subtle changes visuoconstructive demands executive functions may used fast easy perform screening instrument early detection cognitive impairment primary care
thermal conductivity key property controls heat migration variety applications including municipal solid waste mining industrial containment facilities particular heat may encountered cases geosynthetic lining systems exposed elevated temperatures due either waste biodegradation solar radiation mining processes paper presents results experimental investigation thermal conductivity nonwoven geotextiles geosynthetic clay liners hdpe geomembrane steady state method used measure thermal conductivity selected number materials thermal conductivity hdpe geomembrane found consistent thermal conductivity hope polymer hand thermal conductivity nonwoven geotextiles depended water content whether hydrophobic hydrophilic form bentonite mass per area water content affected thermal conductivity gcls results presented paper provide lower bound thermal conductivities geosynthetics routinely used waste containment facilities elsevier ltd rights reserved
effectiveness multicomponent intervention improve problem solving performance students autism spectrum disorders asd vocational tasks examined multiple probe across students design used illustrate effectiveness point view video modeling paired practice sessions self operated cue sheet solve problems encountered vocational tasks following intervention students improved performance generalized problem solving skills second untrained setting three four students maintained performance week follow overall evidence indicated students asd could learn engage problem solving independently following intervention
availability important issue software defined networking sdn paper experiments based sdn testbed showed resource utilization data plane control plane changed drastically ddos attacks happened mainly ddos attacks send large number fake flows network short time based observation analysis ddos defense mechanism based legitimate source destination address database proposed paper firstly flow abstracted source destination address pair legitimate source destination address pair database lsdiad established historical normal traffic trace proportion new source destination address pair traffic per unit time cumulated non parametric cumulative sum cusum algorithm detect ddos attacks quickly accurately based alarm non parametric cusum attack flows filtered redirected middle box network deep analysis via south bound api sdn line updating policy adopted keep lsdiad timely accurate mechanism mainly implemented controller simulation results show mechanism achieve good performance protecting sdn ddos attacks
purpose previous studies examined role empathy nonverbal immediacy business business salesperson performance limited scope yielded inconclusive evidence grounded plank greene framework salesperson effectiveness paper aims empirically investigate mediating role adaptive selling behavior empathy nonverbal immediacy influence sales force performance form empathy cognitive affective beneficial role improving relationship versus outcome salesperson performance design methodology approach using cross sectional data collected pharmaceutical sales representatives study used structural equation modeling test hypothesized relationships findings adaptive selling behavior mediates effect perspective taking empathy empathic concern relationship performance however impact empathy outcome performance significant adaptive selling behavior perspective taking empathy direct influence outcome performance contrary expectations nonverbal immediacy mediated adaptive selling behavior direct positive impact relationship performance research limitations implications results study several implications recruitment training assessment salespeople context based empirical evidence highlighted firms may use different forms empathy nonverbal cues promote adaptive selling behavior impact sales force performance outcome relationship originality value authors knowledge first study simultaneously examines mediating role adaptive selling behavior relationship three antecedent variables relate sales force empathy nonverbal communication perspective taking empathy empathic concern nonverbal immediacy two aspects sales performance relationship outcome
introduction assess ability low dose hybrid iterative reconstruction pure model based mbir images maintain accurate hounsfield unit determined tissue characterization methods standard protocol low dose modified protocol cts contemporaneously acquired crohn disease patients referred image reconstruction via manufacturer recommendations fbp filtered back projection asir adaptive statistical iterative reconstruction asir data sets underwent four reconstructions fbp asir asir mbir three observers measured tissue volumes using thresholds fat soft tissue bone contrast data set analysis via spss results inter observer agreement strong datapoints mbir tissue volume measurement superior reconstructions closely correlated reference asir images tissue types mbir superiority marked fat volume calculation close asir mbir bland altman plot correlation seen lowest average difference compared reconstructions conclusions hounsfield unit determined tissue volume calculations mpmbir images resulted values comparable asir calculations values superior asir images accuracy estimation volume tissues fat using segmentation software low dose images appears optimal reconstructed pure
study focused optimal design adaptive building facade achieving better energy performance iterative facade components design studied virtual physical models integrated tools bim parametric design sensor devices main objectives study exploring systematic design process via analysis adaptive components responsive facade design developing compliance checking system green building regulations developing optimization system adaptive facade design process paper demonstrated integration various digital design methods concluded energy modelling results demo project unit various facade component designs
study considers linear precoding secure transmission multiuser peer peer relay network finite alphabet input assumption global channel state information available achievable secrecy rate derived however computational complexity evaluate achievable secrecy rate grows exponentially respect number pair users reduce computational complexity caused multiuser interference accurate approximation achievable secrecy rate derived based karush kuhn tucker analysis necessary conditions optimal precoder maximises approximated achievable secrecy rate presented light iterative gradient method developed find optimal precoder numerical examples demonstrate proposed scheme achieves significant gains terms secrecy rate schemes designed gaussian input
although vibratory finishing machines widely employed industry years modeling vibratory excitation system machine previously published paper proposes novel mathematical model bowl type vibratory finishing machine model used analyze dynamic behavior mechanical excitation system considering free forced vibrations influence key parameters identified proposed model impact machine performance discussed furthermore implications machine design process optimization presented finally validation developed model presented correlation results obtained theoretical analysis data experimental tests cirp
conditions existence extra mass flux single component dissipative nonrelativistic fluids clarified considering galilean invariance show total mass flux equal total momentum density mass momentum angular momentum booster center mass conserved however conservation laws may fulfilled also means show example weakly nonlocal hydrodynamics conservation laws satisfied well although total mass flux different momentum density
electricity generation using renewable energy sources especially wind solar photovoltaic increasing rapidly replacing fossil generation impact significant small islanded networks historically relied diesel engines generation since wind photovoltaic generation intermittent unpredictable becomes difficult schedule manage small network varying load demand therefore conventional generation kind energy storage required maintain balance total network generation load demand paper presents case study small islanded electrical network western australia various combinations wind turbines photovoltaic modules diesel generators studies impact voltage frequency stability network view maximize penetration renewable energy
new gain enhancement technique operational amplifier opamp using replica amplifier presented reduce sensitivity gain mismatch main amplifier replica amplifier limits gain enhancement factor conventional replica amp techniques proposed technique replica amplifier used amplify error voltage main amplifier outputs main amplifier replica amplifier added cancel error voltage main amplifier proposed technique also achieve higher output voltage swing replica amplifier amplifies error voltage case using fully differential common source opamp main amplifier telescopic opamp replica amplifier monte carlo simulation iterations shows proposed amplifier almost gain variation gain enhancement five times output voltage swing expanding supply voltage compared single closed loop amplifier using telescopic opamp
although bcr abl negative myeloproliferative neoplasms mpn especially myelofibrosis recognized associated autoimmune phenomena immune derangements mpn much less studied myeloid derived suppressor cells mdsc one type important immune modulator cell therefore studied mdscs mpn disease mdscs studied two cohorts first cohort patients including primary myelofibrosis pmf post polycythemia vera post essential thrombocythemia undefined mpn disorder normal controls second cohort included patients pmf patients normal volunteers second cohort studied using freshly collected specimens comparable age group controls cdb cells defined mdscs cohorts flow cytometry since differences mdsc levels among different mpn categories grouped mpns results showed mdscs significantly elevated mpns compared controls cohorts also performed pcr found mpn patients significantly elevated arginase mrna compared controls sorted mdscs found suppressor cell activity mpns substantiating hypothesis levels mdscs fact deranged mpns mdsc levels correlated jak status white blood cells levels platelet counts splenomegaly degree bone marrow fibrosis studies immune therapy involving mdsc inhibitors differentiation may developed treat mpn disease elsevier ltd rights reserved
global optimization algorithm genetic algorithm advantageous tool due global convergence great robustness suitable parallel computing selection optimal parameters maximum generations population size genetic operators crossover fraction mutation fraction extremely crucial particle size characterization ultrasound attenuation spectroscopy genetic algorithm series particle system different distribution functions numerically investigated work revealed simulated results consistent given particle size distribution maximum generations population size crossover fraction mutation fraction appropriate chosen furthermore anti noise performance genetic algorithm three improved forms applied particle system bimodal distribution also studied two groups samples micron sized glass beads glycerol suspension aqueous polystyrene suspension investigated experimentally ultrasound attenuation spectroscopy showed good agreement improved genetic algorithm iga microscope image analysis mia elsevier rights reserved
fluid mechanics lot authors executing researches obtain analytical solutions navier stokes equations even case compressible gas flow case non stationary flow incompressible fluid essential deficiency non stationary solutions indeed explore ansatz derivation non stationary solution navier stokes equations case incompressible flow suggested earlier general case solution obtained mixed system riccati ordinary differential equations regard time parameter find elegant way simplify proper analytical presentation exact solution solution exponentially decreasing zero going infinity infinity also specified solutions constructed considered class perturbation absorbed exponentially going infinity infinity null solution
although cocaine use linked sexual hiv risk behavior decades direct effects cocaine sexual desire sexual decision making unexamined research suggests delay discounting devaluation future outcomes probability discounting devaluation uncertain outcomes play roles condom use decisions study examined effect cocaine administration sexual desire hypothetical condom use discounting tasks double blind within subjects study compared effects oral cocaine hcl cocaine users measures included sexual desire subjective ratings sexual delay discounting task sexual probability discounting task monetary delay probability discounting tasks cocaine caused dose related increases sexual desire prototypical stimulant abuse liability ratings relative placebo cocaine significantly alter condom use likelihood condoms immediately available sex associated certainty sexually transmitted infection sti contrast cocaine dose dependently strengthened effect delay sexual delay discounting sti uncertainty sexual probability discounting decreasing condom use likelihood cocaine caused significant change monetary delay probability discounting first study showing cocaine administration increases sexual desire detrimental effects cocaine sexual risk observed safer sex required delay sti risk uncertain representative many real world scenarios suggesting critical role discounting processes lack monetary effects highlights importance studying clinically relevant outcomes examining drug effects behavioral processes
wireless sensor networks wsns susceptible many security threats specifically prone physical node capture adversary easily launch called insider attacks node compromise bypassing traditional security mechanisms based cryptography primitives compromised nodes modified misbehave disrupt entire network successfully perform authentication process neighbors way distinguish fraudulent nodes trustworthy ones trust reputation systems recently suggested powerful tools attractive complement cryptography based schemes securing wsns provide ability detect isolate faulty malicious nodes considerable research done modeling managing trust reputation however trust topic issue wsns remains open challenging field paper propose risk aware reputation based trust rartrust model wsns novel framework uses reputation risk evaluate trustworthiness sensor node risk evaluation used deal dramatic spoiling nodes makes rartrust robust attack differ trust models based reputation paper contributes model risk opinion short term trustworthiness combining traditional reputation evaluation derive trustworthiness wsns
objective objective study develop new solubility enhancement strategy antipsychotic drug perphenazine ppz form amorphous nanoparticle complex nanoplex polyelectrolyte dextran sulfate dxt significance poor bioavailability ppz necessitated development fast dissolving ppz formulations regardless delivery routes existing fast dissolving formulations however exhibited low ppz payload high payload ppz dxt nanoplex represents attractive fast dissolving formulation dissolution rate known proportional payload methods nanoplex prepared electrostatically driven complexation ppz dxt simple process involved ambient mixing ppz dxt solutions investigated effects key variables drug polyelectrolyte complexation charge ratio dxt ppz physical characteristics preparation efficiency nanoplex produced subsequently characterized colloidal amorphous state stabilities dissolution enhancement supersaturation generation nanoplex prepared optimal condition results physical characteristics nanoplex governed dxt ppz preparation efficiency governed preparation nanoplex size approximate zeta potential approximate payload approximate prepared nearly ppz utilization rate approximate yield nanoplex exhibited superior dissolution native ppz simulated intestinal juice resulting high prolonged apparent solubility good storage stabilities conclusions simple yet efficient preparation excellent physical characteristics fast dissolution high apparent solubility exhibited ppz dxt nanoplex established potential new bioavailability enhancement strategy ppz
work focused system boundary value problems whose solutions represent equilibria bridge suspended continuously distributed cables supported intermediate piers road bed modeled junction extensible elastic beams clamped pinned ends pier suspending cables modeled one sided springs stiffness stationary solutions doubly nonlinear problems explicitly analytically derived arbitrary general axial load applied ends bridge particular scrutinize occurrence buckled solutions connection length sub span bridge
efficient application solar energy pebble bed energy storage heating system solar attic optimally designed operated study characteristics heating system numerical model system presented validated experiment data literature based model influence envelopes solar house meteorological condition system performance investigated results show envelopes except north face glazed exterior surfaces beneficial raise temperature solar house also found outdoor temperature may less impact energy storage system compared solar radiation furthermore optimizing system design operation solar energy account energy requirement heating season degrees degrees average altitude moderate solar irradiation also suitability system northwest china investigated outcome demonstrates external comprehensive temperature energy saving rate expected
paper analyzes electromechanics spherical metal particles gas insulated lines gil pragmatic test rig comprising coaxial cylindrical electrodes analysis fluid resistance particle moving process presented based fluid mechanics well kinetic parameters mixture interactive impacts particle conductor shell also proposed based collision theory elastic mechanics considering random effects caused metal surface roughness aspects included dynamic motion model spherical metal particles within gil established accordingly experimental studies carried validate effectiveness accuracy proposed model meanwhile simulations done regarding real gil governance verifications research observations indicate applied voltage exerts incremental effect maximum height moving particle affect spread angle particle motion height spread angle particle motion show inflection points increased particle radius contrary maximum height moving particle decreases increase ratio gas pressure
objective estimate effect participating cognitive cooperation groups mediated computers internet mini mental state examination mmse percent variation outpatients memory complaints attending two memory clinics methods prospective controlled intervention study carried elders intervention group attended cognitive cooperation group sessions hours control group received routine medical care outcome percent variation mmse control variables included gender age marital status schooling hypertension diabetes dyslipidaemia hypothyroidism depression vascular diseases polymedication use benzodiazepines exposure tobacco sedentary lifestyle obesity functional capacity final model obtained multivariate linear regression results intervention group obtained independent positive variation mmse compared control group conclusion results suggested cognitive cooperation groups mediated computers internet associated cognitive status improvement older adults memory clinics
macro hybrid mixed variational models two phase flow fractured porous media analyzed mesoscopic macroscopic levels mesoscopic models treated terms nonoverlapping domain decompositions manner porous rock matrix system fracture network interact across rock rock rock fracture fracture fracture interfaces flux transmission conditions dualized alternatively models scaled macroscopic level via asymptotic process width fractures tends zero fracture network turns interface system one less spatial dimension variable high permeability two phase flow characterized fractional flow dual mixed variational model augmented two field three field variational reformulations presented regularization internal approximations macro hybrid mixed finite element implementation also abstract proximal point penalty duality algorithms derived analyzed parallel computing copyright john wiley sons ltd
lung transplantation using rna hepatitis hcv donors seronegative recipients currently performed due high risk transmission previous reports shown poor survival practice applied emergence new direct acting antiviral drugs daa suggests high chance sustained virologic response immunocompetent patients report successful transplantation lungs hcv donor hcv recipient recipient hcv patient chronic lung allograft dysfunction viral transmission occurred early posttransplant excellent clinical outcomes observed including elimination hcv weeks treatment using daas
teacher centered traditionally playing role basic teaching method long time way students perceive learn subject content class seems remember content taking exam hand time comes solve real problems usually find difficulty accomplish due lacking practical experience basic programming skills compulsory factor students information technology field memorizing content knowledge adequate learning programming subjects students practice actual work comprehensive understanding study represents teaching processes applied problem based learning technique learning directions communications lecturer student freshmen computer programming subject school mae fah luang university target group empirical study
although hepatitis virus hev regarded self limiting infection anti hev antibodies seem protect reinfection pathogenesis well established describe cases acute symptomatic hev infection hepatitis therapy patients carrying anti hev immunoglobulin antibodies raising major questions reactivation reinfection
introduction essential thrombocythemia philadelphia chromosome negative chronic myeloproliferative neoplasia risk bleeding thromboembolic complications course illness cytoreductive drugs non selective hydroxyurea interferon first line specific megakaryocyte thrombocyte reductive anagrelide chosen second line treatment cases adverse intolerable effects hydroxyurea lower incidence bleeding thrombotic episodes patients essential thrombocythemia aim observational survey effect anagrelide investigated patients essential thrombocythemia first treated hydroxyurea failed clinicopathologic reponse resistant intolerant adverse effects method patients diagnosed essential thrombocythemia treated first line hydroxyurea weekly median dose haematologic outpatient department authors intolerance resistance hydroxyurea changed anagrelide weekly median dose doses hydroxyurea anagrelide adjusted achieve clinicopathological response according updated criteria european leukemianet effect anagrelide monotherapy first second line hydroxyurea combination hydroxyurea followed statistical analysis performed using windows statistical package program results patients essential thrombocythemia according updated classifications patients jakvf mutation positive patients negative patients calreticulin mutation negative patients mpl mutation negative patients received hydroxyurea first line patients interferon patients acetylsalycilic acid seven patients proved intolerant patients resistant hydroxyurea received anagrelide second line patients monotherapy patients combination hydroxyurea rather young patients first line therapy anagrelide first line group patients second line anagrelide monotherapy group patients combined hydroxyurea plus anagrelide group patients achieved complete remission year overall survival patients treated anagrelide major bleeding one patient myocardial infarction occurred serious adverse events due anagrelide treatment detected three elder patients died non hematologic diseases leukaemic transformation observed conclusions first second line anagrelide therapy combined hydroxyurea necessary able reduce platelet count rate complications control course essential thrombocythemia tolerable adverse effects
paper presents scheme improve line current distortion power factor corrector pfc topology zero crossing point using predictive control algorithm continuous conduction mode ccm discontinuous conduction mode dcm line current single phase pfc topology distorted zero crossing point input voltage characteristic general proportional integral current controller distortion degrades line current quality total harmonic distortion thd power factor given optimal duty cycle calculated estimating next state current ccm dcm proposed predictive control algorithm fast dynamic response accuracy unlike conventional current control method advantages proposed algorithm lower line current distortion pfc topology proposed method verified psim simulations experimental results bridgeless pfc blpfc topology
environmental regulation coal mine greater sydney area failed recognise importance protect high conservation value river located world heritage listed area study measured water quality ecological health using macroinvertebrates wollangambe river tributaries near point waste water discharge coal mine assessed longitudinal impact downstream investigation revealed two important aspects first significant impact waste water discharge compared otherwise near pristine condition high conservation value river system second spatial extent pollution mine extends least downstream outflow coal mine wastes resulting water pollution causing major impairment aquatic ecosystem reduced abundance taxonomic richness loss pollution sensitive macroin vertebrate groups water pollution mine includes thermal pollution increased salinity increased concentrations zinc nickel mine waste discharge also strongly modified river ionic composition study also highlights failure regulatory governance systems enable mine operate manner causes major environmental impacts
tested across three studies effect cultural life script memory phenomenological properties focused particular mnemonic effects schema consistency frequency life script addition testing recognition study recall studies also collected remember know judgements remembered events studies memory emotional valence study primary finding across three studies higher frequency events memorable lower frequency events measured either recognition recall also attained three additional complementary effects first schema inconsistent events received remember ratings often schema consistent events study trend effect study second event emotional valence inconsistent life script memory valence reconstructed fit script study third intrusions recall disproportionately life script events study although case recognition study conclude life script serves cognitive schema shapes memory phenomenological properties
many case control designs genome wide association gwas next generation sequencing ngs studies extensive data secondary traits may correlate share common genetic variants primary disease available investigating secondary traits provide critical insights disease etiology pathology enhance gwas ngs results methods based logistic regression developed purpose however identification rare variants rvs certain inadequacies models algorithmic instability cause severely inflated type error significant loss power two traits correlated associated disease especially stringent significance levels address issue propose novel set valued method models binary trait dichotomization underlying continuous variable incorporate genetic association model critical component extensive simulations analysis seven secondary traits gwas benign ethnic neutropenia show method consistently controls type error well stringent significance levels larger power based methods robust performance effect pattern genetic variant risk protective rare common variants rare common diseases trait distributions method striking profound advantage strongly recommend method employed instead based methods secondary traits analyses case control sequencing studies
background date association obesity lower urinary tract symptoms luts controversial objective overcome current inconsistent results regarding association obesity luts investigate association obesity luts using propensity score matching analysis setting bariatric center excellence health promotion center university hospital methods august december total obese patients men women visited bariatric center undergo bariatric surgery patients international prostate symptom score lpss overactive bladder symptom score compared healthy controls visited health center period control effects age propensity score matching used results matching propensity score forage male patients female patients included study men lpss items except frequency significantly different obese patients controls median scores higher obese group women ipss items except feeling incomplete emptying significantly different groups voiding storage subscores also marked differences genders total rpss quality life total overactive bladder symptom score significantly different genders conclusion marked differences luts obese nonobese patients including voiding storage symptoms considering relatively young age groups case control study supports hypothesis relationship obesity bladder pathophysiology published elsevier inc behalf american society metabolic bariatric surgery
managing servers integration realize distributed data computing framework important concern regardless underlying architecture actual distributed system complexity framework gives programmers abstract view systems achieve variously data intensive applications however state art frameworks need much library dependencies parameters configuration lack extensibility application programming moreover general framework precise design nontrivial work fraught challenges task scheduling message communication computing efficiency etc address problems present general scalable programmable parallel computing framework called sunwaymr needs gcc environment argue following aspects distributed data partitioning message communication task organization given support transparent application execution parallel hardware searching threads table node task gets idle thread preferred node address executing data partition novel communication component sunwaymrhelper employed merge periodical results synchronously identifying whether current node master slave sunwaymr deals periodical task results differently optimizations simple fault tolerance given resume data parallel applications thread level stringstream utilized boost computing ensure ease use open application programming interface api excerpts invoked various applications fewer handwritten code openmpl mpi conduct extensively experimental studies evaluate performance sunwaymr real world datasets results indicate sunwaymr runs computational nodes outperforms spark various applications good scaling data sizes nodes threads elsevier rights reserved
spreading depolarizations implicated diverse set neurologic diseases unusual forms nervous system activity propagate slowly approximately concentrically apparently respecting anatomic synaptic functional vascular architecture brain however evidence spreading depolarizations truly concentric isotropic homogeneous either space time present evidence kcl induced spreading depolarizations mouse rat invivo invitro showing great variability depolarizations exhibit variability help inform mechanistic understanding spreading depolarizations implications phenomenology neurologic disease
shape memory function new smart material magnetic control properties magnetic shape memory alloy could used fabricate intelligent actuators vibration control structures order study magnetic properties text selected nimnga material research development actuator drive two msma test specimens prepared experimental study coupled action temperature preload pressure magnetic field results showed strain msma induced magnetic field decreased increase preload pressure constant magnetic field deformation performance best magnetic induction intensity constitutive relations fitted actuator production lay foundation later
since twentieth century studies demonstrated impact media channels beneficiaries especially children adolescents transmission moving images concept information rapidly expanded vertically technological development improved information quality terms details horizontally broadening target audience gradually contemporary society written press television radio entered almost houses various ways impact mass media evolved technology currently large number social events press trigger element paper authors start case study illustrate negative impact violence conveyed media channels children adolescents generating increasing aggressiveness
investigate control technique suitable dynamic positioning overactuated platform end develop backstepping model predictive controller mpc presence redundant control inputs makes stabilization position orientation platform challenging settling delays actuator thrust angle thrust saturation bounds jet rotational velocity bounds contribute challenge problem reduce energy consumption propose technique restricting parasitic thrust effect significant energy reduction due parasitic thrust restriction illustrated tables performance controllers demonstrated simulations realistic environmental disturbances compared model based pid controller previously developed platform accomplishes two typical tasks evaluation criteria include energy consumption robustness accuracy dynamic positioning results show superiority mpc
study studies precision motion control developed planar motor motion system existence external disturbance non linearity uncertainty crosstalk coupling problems inevitably deteriorate achievable control object even make system unstable address issues integrated robust tracking controller consists feedforward proportional integral derivative pid robust compensator developed planar motor stage practically achieve high control performance specifically term designed based stage dynamics model reduce tracking error pid term synthesised pole assignment stabilise nominal model importantly particularly designed suppress effects equivalent lumped disturbances including external disturbances uncertainties non linearities crosstalk couplings proposed integrated controller possesses robust stability uncertain disturbances facilitates parameter tuning meaningful practical implementation finally comparative experiments conducted developed planar motor wafer stage results validate practical effectiveness high performance nature proposed control strategy
present first time analytic solutions nonlinear dynamics wien bridge oscillator stabilised three common methods incandescent lamp signal diodes field effect transistor results used optimise oscillator design agree well measurements effect operational amplifier marginal nonlinearity oscillator performance high frequencies clarified oscillator circuits analysis used demonstrate nonlinear dynamics undergraduate laboratory
advisory ratings content descriptions assigned motion pictures motion picture association america mpaa represent primary social policy united states advising parents movie content goal limiting minor children exposure material deemed inappropriate age examine possible historical trends mpaa ratings information present study analyzed content movie rating justification phrases rated violence language applied movies released years random sample movie titles selected words rating justification phrases coded primary content terms modifier terms results indicated content terms language violence sexuality appeared frequently rating levels historical trends found terms indicating stronger depictions violence language mature thematic material movie phrases adult language substance use sexual content movie phrases across sampled years pattern termed ratings creep policy changes psychological processes affecting mpaa raters ratings process discussed plausible causes ratings creep implications ratings changes media consumers society large
autoimmune diseases occur immune system generates proinflammatory molecules autoantibodies mistakenly attack body traditional diagnosis autoimmune disease primarily based physician assessment combined core laboratory tests however tests sensitive enough detect early molecular events quite often late control autoimmune diseases reverse tissue damage conventional tests show positivity disease fortunate past decade research nanotechnology provided enormous opportunities development ultrasensitive biosensors detecting early biomarkers high sensitivity biosensors consist biorecognition element transducer able facilitate accurate detection proinflammatory molecules autoantibodies disease causing molecules apparently novel biosensors could superior traditional metrics assessing drug efficacy clinical trials especially specific biomarkers indicative pathogenesis disease furthermore portability biosensor enables development pointof care devices review various types biomolecule sensing systems including electrochemical optical mechanical sensors applications future potentials autoimmune disease treatment discussed
paper presents study televised political debates based integrated model simultaneously examines verbal nonverbal communication interconnections integrative approach yields better explanatory power separate analysis modalities model used analyze televised debates israeli election campaigns identify consistent discrepancy nondiscrepancy patterns behavior winners losers model also sheds light gender differences similarities novel perspective discrepant nondiscrepant communication styles set propositions kinds behaviors might beneficial detrimental contenders televised debate provided
ross river virus rrv mosquito transmitted alphavirus prevalent australia believed cause poor performance lethargy muscle stiffness australian horses however disease progression management poorly documented better understanding disease presentation acute therapy long term management required aim study describe clinical presentation diagnosis acute treatment long term management rrv infection horses study series retrospective case reports clinical diagnostic data obtained veterinary records owner interviews five performance horses presented acute poor performance coupled serologic evidence rrv exposure clinical owner reports evaluated time presentation horses appeared asymptomatic returned normal performance ross river virus suspected cause generalized muscle stiffness poor performance five performance horses located southeast queensland clinical symptoms included pyrexia tachypnea exercise intolerance generalized muscle stiffness synovial effusion edema lower limbs serologic investigations elisa virus neutralization assay detected antibody responses rrv horses treated nonsteroidal antiinflammatory drugs disease modifying osteoarthritis drugs horses returned previous athletic capabilities months onset symptoms horses study preclinical serology submitted paired blood samples serology meaning assumption acute infection horses made based clinical signs coupled positive serology ross river virus significant poorly understood cause poor performance australian horses report one document longitudinal management performance horses affected rrv infection much research needed gain better understanding infection horses elsevier inc rights reserved
structural design paradigm evolved engineering oriented approach holistic one accommodates various concerns including form function behavior economy efficiency elegance many aspects possible must considered early design stages reduce downstream problems afterward design tool stage iterative interactive designers manipulate various alternatives addition advancement computer graphics software together generative algorithms provide rapid dynamic simulation enables efficient interactive design research focused rapid prototyping development computer supported design tool helps perform conceptual design suspension bridges designer concept computer simulation conceptual design stage design information tasks conceptual design formalized terms entities using concept entity based model entities implemented generative algorithms graphic software thanks dynamic simulation implemented design tool conceptual design done interactively iteratively generating selecting design alternatives following graphical approach
ultrasonic ranging technology used widely many industries around world paper aims design manufacture ultrasonic distance measuring system lower price higher accuracy based deep study principle ultrasonic ranging designed general plan detailed electrical circuits ultrasonic distance measuring system based single chip microprocessor ats including transmitter module ultrasonic wave receiving module ultrasonic wave display module etc compiled relative driven programs modules debugged combined system hardware software system last experimental results show cost rmb prototypes measuring rang similar accuracy means ranging system meets design requirements lower price higher accuracy
study examines chinese post women meanings work intersections gender generation culture feminist ventriloquial approach used tease enactment tensions communicative constitutions colloquialism hao gongzuo good work figures women personal aspirations gender roles cultural generational values material conditions chinese workplace ventriloquize everyday constructions study finds post women perpetuators dissidents gendered national cultural work ideology negotiate various tensions frame good work wending stable timian face adding status promoting yourenyouyu fulfilling achieving situated context transitional developing country rooted eastern traditions study unpacks various discursive material forces engage tensional constructions work meanings sheds light women career socialization gender equity chinese workplace
traditional forensic analysis hard disks external media typically involves dead analysis powered machine forensic acquisition hard drives external media traditionally accomplished one several means standalone forensic duplicator using hardware write blocker dock attached laptop computer workstation etc forensic operating systems live boot usb dvd virtual machines preinstalled operating systems standalone forensics acquisition imaging devices generally cost thousands dollars paper propose use single board computers forensic imaging devices single board computers provide low budget forensic imaging solution used lab remote acquisition even configured portable imaging devices project tests different arm processor based single board computers software available present time project includes image acquisition using write blocker software write blockers without write blockers test various configurations final results demonstrate clearly arm based single board computers serve effective low cost low energy forensic imaging devices
magnetic resonance imaging mri widely used clinical setting well research applications since inception technical development broadly progressed response challenges clinical research settings higher magnetic field strength advances hardware software revolutionized diagnostic potential mri moved well beyond diagnosis characterization tissue metabolism biochemistry disease pathogenesis material property name article focuses state art clinical cutting edge novel pulse sequences applied knee mri
spinal cord injury sci devastating event individuals frequently develop motor sensory impairment well autonomic dysfunction previous studies reported autonomic activity plays major role social cognition difficulties ability interpret social information commonly observed variety mental disorders turn correlate poor autonomic nervous system ans regulation well established subjects sci alteration ans regulation mechanisms hypothesized subjects diagnosed sci experiencing period adaptation socio labor insertion suffer alterations emotion recognition task component social cognition correlate poor ans regulation evaluated ans function measuring heart rate variability hrv healthy subjects subjects sci min baseline hrv compared task period performing reading mind eyes test rmet found groups similar general performance test healthy subjects responded greater certainty rmet level certainty rmet positively correlated baseline hrv measures group also group healthy subjects exhibited higher hrv baseline participants sci finally changes hrv baseline task condition significantly higher healthy individuals sci participants results show patients sci low levels autonomic regulation mechanisms may promote social cognition problems reinsertion daily life
affordable care act aca obamacare monumental change health care policy since passage medicaid medicare since enactment numerous claims made sides aisle regarding aca success failure views often colored political persuasion aca primary goals increasing number insured improving quality care reducing costs health care one point often lost discussion distinction affordability access health insurance financial mechanism paying health care access refers process actually obtaining health care aca widened gap providing patients mechanism paying healthcare actually receiving aca applauded increasing number insured quite appropriately occurred million people less frequently mentioned million lost insurance terms health insurance provided majority expansion based medicaid expansion increase million consequently aca worked well working middle class receive much less support particularly earn federal poverty level constitute population receive help result exchange enrollment disappointment percentage workers obtaining health benefits employer decreased steadily access health care uneven medicaid hampered narrow networks exchanges getting employer benefits faced high pocket costs second category relates cost containment president obama claimed aca provided significant cost containment costs would even much higher aca enacted attributed cost reductions generally aca taking account factors recession increased pocket costs increasing drug prices reduced coverage insurers final goal improvement quality effort improve quality led creation dozens new agencies boards commissions government entities turn practice management regulatory compliance costs increased structurally solo independent practices lack capability manage new regulatory demands declined hospital employment associated increased costs soaring despite focus preventive services management chronic disease health care expenditures spent preventive services costs managing chronic disease continue escalate aca consequential comprehensive health care reform enacted since medicare aca gained net increase number individuals insurance primarily medicaid expansion reduction costs arguable achievement quality care seemingly improved finally access seems diminished review attempts bring clarity discussion reviewing aca impact affordability cost containment quality care discuss aspects aca perspective proponents opponents pragmatic point view
paper aims study design practice sports injuries network consultation according sports injuries study theory combine internet technology module theory designed sports injuries network consultation system paper makes explanation design ideas technology crucial module function design working example system system appraisal sports injuries give treating plan exercise rehabilitation prescription provide internet platform sports injuries treating counseling students teachers system important practice promotion values
present work attempts investigate effect compression ratio injection timing energy exergy potential biogas run dual fuel diesel engine experimentation single cylinder four stroke direct injection naturally aspirated water cooled variable compression ratio diesel engine converted dual fuel engine experiments conducted different combinations comprising degrees top dead center btdc crs full load condition bar brake mean effective pressure parameters analyzed energy exergy potential fuel input shaft work cooling water exhaust gas exergy destruction peak cylinder pressure peak heat release rate brake thermal efficiency exergy efficiency exhaust gas temperature entropy generation rate thermodynamic analysis indicates combination degrees btdc gives improved performance biogas run dual fuel diesel engine american society civil engineers
relationships corticotropin releasing hormone receptor crhr serotonin transporter promoter polymorphism httlpr resilience satisfaction life examined adolescents refugee adolescents living netherlands non refugee dutch adolescents genetic variation crhr related self reported resilience satisfaction life httlpr polymorphism findings depend refugee non refugee dutch adolescent hold accounting age number exposures potentially traumatic events gender implies adolescents allele carriers crhr might susceptible mental health problems following trauma suggesting innate differences crhr factor resilience elsevier ltd rights reserved
investigation paper canonical system describes marginally unstable baroclinic wave packets geophysical fluids ultra short pulses nonlinear optics symbolic computation conservation laws derived furthermore virtue darboux transformation explicit multi soliton solutions generated figures plotted reveal following dynamic features solitons elastic interactions two one peak bright solitons two one peak dark solitons two two peak dark solitons parallel propagations two one peak bright solitons two one peak dark solitons two two peak dark solitons propagations three types bound solitons periodic propagation bound solitons taking contrary trends mutual attractions repulsions two bight bound solitons two dark bound solitons elsevier inc rights reserved
background aims identifying best method estimate glomerular filtration rate gfr bariatric surgery patients important implications clinical care obese patients research impact obesity weight reduction kidney health therefore performed analysis patients surgical weight loss methods fasting measured gfr mgfr plasma iohexol clearance bariatric surgery obtained severely obese individuals estimated gfr calculated using modification diet renal disease equation chronic kidney disease epidemiology collaboration ckd epi equation using serum creatinine ckd epi equation using serum cystatin recently derived equation uses serum creatinine cystatin ckd epicreat cystc compared mgfr results participants primarily middle aged white females mean baseline body mass index serum creatinine mgfr min mgfr stronger linear relationship inverse cystatin surgery compared inverse creatinine mgfr fell min following surgery ckd epicreat cystc unquestionably best overall performing estimating equation surgery revealing little bias capacity estimate mgfr within true value time true whether mgfr indexed body surface area conclusions severely obese bariatric surgery patients normal kidney function cystatin strongly associated mgfr serum creatinine ckd epicreat cystc equation best predicted mgfr surgery karger basel
work presents network model simulate periodic behavior double acting free piston type stirling engine component engine considered independently equivalent electrical circuit derived assembled global electrical network global model engine established steady behavior obtained analysis transfer function one phase piston expansion chamber possible simulate dynamic steady state stroke operation frequency well thermodynamic performances output power efficiency given mean pressure heat source heat sink temperatures motion amplitude especially determined spring mass properties moving parts main nonlinear effects taken account model thermodynamic features model validated using classical isothermal schmidt analysis given stroke three phase low temperature differential double acting free membrane architecture built tested experimental results compared model satisfactory agreement obtained stroke operating frequency predicted less error whereas output power discrepancy finally optimization routes suggested improve design maximize performances aiming waste heat recovery applications elsevier ltd rights reserved
beta peptides main protein components alzheimer disease plaques derive proteolytic cleavage amyloid precursor protein due heterogeneous cleavage sites series beta peptides including major widely studied species beta beta beta beta produced addition terminal heterogeneity beta peptides significant amounts terminal truncated beta pyroglutamate modified amyloid beta peptides beta identified affected brains shown cytotoxic unmodified beta peptides little known properties mixtures beta nuclear magnetic resonance spectroscopy employed investigate interaction truncated peptides beta different molar ratios highlight critical concentration truncated forms influencing aggregation kinetics beta provide evidence residue level terminal region beta locus transient specific interactions highly aggregation prone truncated alloforms
majority studies investigated empathic responsiveness individuals autism spectrum disorder asd used heterogeneous groups terms age cognitive level gender significantly impact results aim study explore responsiveness homogenous sample children asd typically developing controls aged years overt expressed anticipated distress anticipated distress task groups differentiated response towards experimenter drawing torn expressed distress task groups similar expressing concern acting prosocially towards experimenter pretended lose watch theoretical clinical implications findings discussed
recent rise use third party standards rating systems evaluate sustainability greenness urban programs policies includes explicit incorporation municipal policy case certified green buildings paper theoretical framework performativity used explain multiple forms city activity interlock policy name repeat recount city leader particular discursive formation means green performing greenness peers city staff elected officials work city identity innovator leader furthermore internal performance greenness residents businesspeople indicates appropriate role local government relation private sector activity protecting citizens including taking risks new technologies practices ease way private capital
fundamental optimization problem vehicle routing problem wide application backgrounds paid lots attentions past decades paper study applications data gathering wireless energy charging wireless sensor networks devising improved approximation algorithms variants key ingredients algorithm design include exploiting combinatorial properties problems making use tree decomposition minimum weighted maximum matching techniques specifically given metric complete graph integer consider rootless uncapacitated rooted capacitated rooted min max cycle cover problems aim find rootless rooted edge disjoint cycles covering vertices maximum cycle weight among cycles minimized mentioned problems develop improved approximate solution rootless min max cycle cover problem develop epsilon approximation algorithm uncapacitated rooted min max cycle cover problem devise epsilon approximation algorithm capacitated rooted min max cycle cover problem propose epsilon approximation algorithm algorithms improve best existing approximation ratios corresponding problems epsilon epsilon epsilon respectively epsilon constant finally evaluate performance proposed algorithms experimental simulations experimental results show actual approximation ratios delivered proposed algorithms always much better analytical counterparts
radar evasion stealth technology desirable among military research areas currently pursued research organisations focused attention electronic stealth technology cancellation waves since feasible due improvement high end processing fast electronic systems attempt increase understanding field analysed phenomenon computer aided simulation paper created electromagnetic wave simulation platform using finite difference time domain method analysed method active cancellation found results showing complete effectiveness method assured accuracy fdtd method authors published elsevier
objective exploratory study provided proof concept new procedure using multivariate electroencephalographic eeg topographic markers cortical connectivity discriminate normal elderly nold alzheimer disease individuals method new procedure tested existing database formed resting state eyes closed eeg data exploring electrodes system referenced linked ear reference electrodes recorded patients dementia age years standard deviation nold non consanguineous caregivers age years procedure spectral eeg coherence estimated reciprocal functional connectivity non normalized directed transfer function ndtf estimated effective connectivity principal component analysis computation mahalanobis distance integrated combined eeg topographic markers cortical connectivity area receiver operating curve auc indexed classification accuracy results good classification nold individuals obtained combining eeg markers derived ndtf coherence auc sensitivity specificity conclusion encouraging results motivate cross validation study new procedure ageand education matched nold stable progressing mild cognitive impairment individuals novo patients dementia significance cross validated new procedure provide cheap broadly available repeatable time entirely non invasive eeg topographic markers reflecting abnormal cortical connectivity patients diagnosed direct indirect measurement cerebral amyloid beta hyperphosphorylated tau peptides international federation clinical neurophysiology published elsevier ireland ltd rights reserved
recently increasing studies mirna expression profiling confirmed mirna plays essential role non small cell lung cancer nsclc however inconsistent discrepant results exist researches present study performed integrative analysis mirna profiling studies compared differentially expressed mirna nsclc tissue non cancerous lung tissue identify candidate mirnas associated nsclc upregulated downregulated mirnas identified mirna integrated signature using robust rank aggregation rra method qrt pcr demonstrated mir mir mir mir mir mir mir regulated whereas mir mir mir mir mir regulated folds nsclc validated tumor cancer genome atlas tcga database receiver operating characteristic roc curve analysis confirmed mirnas good predictive performance auc cox regression analysis revealed mir hazard ratio mir independent prognostic factors nsclc overall survival accumulative effects two mirnas prognosis nsclc estimated results showed patients two positive markers worse prognosis one none positive marker conclusion study contributes comprehension role mirnas nsclc provides basis clinical application
nowadays significant part network accesses comes embedded battery powered devices must energy efficient paper demonstrates hardware implementation network security algorithms significantly reduce energy consumption compared equivalent software version paper four main contributions new feature extraction algorithm low processing demands suitable hardware implementation feature selection method two objectives accuracy energy consumption iii detailed energy measurements feature extraction engine three machine learning classifiers implemented decision tree naive bayes nearest neighbors knn detailed analysis tradeoffs implementing feature extractor classifiers new feature extractor demands significantly less computational power memory energy implementation consumes percent energy used commercial product implementation percent dual objective feature selection enabled energy saving percent comparing energy efficient implementation new extractor classifier equivalent implementation version consumes percent energy used version
performance electrical machines ultimately limited thermal issues facilitate modelling speed time market novel designs accuracy efficiency reliability thermal models improved literature majority thermal models electrical machines based lumped parameter thermal networks efficient simple implement accuracy main concern related approach moreover outputs thermal models average temperatures suitable constraint machine design work introduce improved lumped parameter configuration based novel structure distributed losses capacitance dlc element dlc able accurately estimate local temperatures steady state transients high biot number high aspect ratios validate approach experimentally creating thermal model external rotor surface mounted permanent magnet spm machine error estimation end windings temperature within
paper starts presenting new concept differentiation similarity transformations commensurate pseudo states space representations proven pseudo state space representation commensurate differentiation order dimension transition matrix similar pseudo state space representation commensurate order dimension transition matrix integer number direct consequence aforementioned concept fractional subspace based identification methods mimo systems overestimated pseudo state space representation multiple minimums commensurate differentiation orders integral number result especially visible deterministic input output signals considered less visible stochastic case due overestimation
although many changes discovered heart maturation genetic mechanisms involved changes immature mature myocardium partially elucidated gene expression profile changed human fetal adult heart characterized human microarray applied define gene expression signatures fetal weeks gestation adult hearts years old gene ontology analyses pathway analyses gene set enrichment analyses signal transduction network performed predict function differentially expressed genes ten mrnas confirmed quantificational real time polymerase chain reaction mrnas found significantly differentially expressed cell cycle enriched pathway regulated genes efgr igfr itgb play central role regulation heart development egfr igfr fgfr core genes regulating cardiac cell proliferation quantificational real time polymerase chain reaction results concordant microarray data data identified transcriptional regulation heart development second trimester potential regulators play prominent role regulation heart development cardiac cells proliferation
fluid mechanics problem relevant foam fractionation processes analysed specifically fluid flow field transporting surfactant foam plateau borders fed surfactant rich material towards comparatively surfactant lean foam films considered extent surfactant mass transfer limited surface viscous effects studied previous work vitasari made assumptions likely flow field along plateau border surface assumptions suggested high surface viscosity measured suitable dimensionless parameter led strong suppression rate surfactant mass transfer plateau border film whereas low surface viscosity suppress mass transfer rate significant way detailed fluid mechanical calculations carried corroborate aforementioned assumptions high surface viscosity regime however calculations suggest low surface viscosity regime contrast findings previous assumptions moderate reductions rate surfactant mass transfer also possible counterintuitively moderate reductions mass transfer rate potentially negative impact fractionation processes aforementioned strong suppression tend arise conditions efficiency fractionation system particularly sensitive reduction whatsoever surfactant mass transfer rate elsevier ltd rights reserved
major product biodiesel production waste glycerol numerous potential applications study isolated novel bacterium capable producing cellulose waste glycerol identified novel strain named nedo gluconacetobacter intermedius scanning electron microscopy revealed morphology pellicle produced nedo similar cellulose produced gluconacetobacter hansenii atcc furthermore ray diffraction solid state nuclear magnetic resonance spectroscopic analyses suggested cellulose produced nedo molecular crystalline structures similar cellulose produced atcc optimization cultivation conditions nedo mediated one step production nanofibrillated bacterial cellulose nfbc waste glycerol medium supplemented carboxymethyl cellulose transmission electron microscopic analysis revealed nfbc composed relatively uniform fibers diameters approximately nfbc produced uniform water suspensions yield cultivation medium jar fermenter bioconversion waste glycerol nfbc superior fluidity moldability miscibility wide variety applications including potential uses medical materials engineering fields
acrylates widely used synthesis pharmaceutical polymers quantitation residual acrylate monomers vital strong irritants allergens polymerization relatively inert causing irritation allergies poly ethylene oxide peo hydrogels prepared using pentaerythritol tetra acrylate petra crosslinking agent simple accurate robust quantitation method developed based gas chromatographic techniques suitable routine analysis residual petra monomers hydrogels unreacted petra initially identified using gas chromatography mass spectrometry quantitation analyte performed validated using gas chromatography equipped flame ionization detector fid linear relationship obtained range correlation coefficient greater recovery intra day precision rsd inter day precision rsd robustness rsd method within acceptable values limit detection lod limit quantitation loq respectively assay provides simple quick way screening residual acrylate monomer hydrogels jiaotong university production hosting elsevier
paper presents responses opinion small number test users experimented temperature control system offline via internet hardware arduino based system accessible via labview online system developed frame bsc thesis project testing inclusion control engineering courses undergraduate mechanical energy engineering students among reasons thesis topic need extend learning sources beyond classical textbooks collections example problems simulated problems today hardware software resources readily available quite low cost flexibility usage presented system implemented hungarian time writing volunteer testers used results considered pre pilot study however feedback proves project pursued enhancements based user responses worked presented setup wide availability ease use arduino labview allow interested users reproduction extension system based needs interests
extremal optimization nature inspired optimization method features small computational memory complexity due features efficiently used engine processor load balancing paper presents improved extremal optimization algorithms applied processor load balancing extremal optimization detects best strategy tasks migration leading balanced application execution reduction execution time proposed algorithm improvements cover several aspects one algorithms parallelization multithreaded environment second one adding problem knowledge improve convergence algorithms third aspect enrichment parallel algorithms inclusion elements genetic algorithms namely crossover operation load balancing based improved extremal optimization aim better convergence algorithm smaller number task migrations done reduced execution time applications quality proposed algorithms assessed experiments simulated parallelized load balancing distributed program graphs
background purpose studies evaluate effects evacetrapib male female fertility embryo fetal development efd methods evacetrapib potent selective inhibitor cholesteryl ester transfer protein cetp administered daily oral gavage starting weeks female weeks male mating cohabitation necropsy male rat fertility study gestation day female rat combined fertility efd study rabbit efd studies animals dosed gds week mating dose levels evacetrapib ranged rats day rabbits results parental findings rats included decreased body weight food consumption moribund euthanasia animals given day decreased food consumption day adverse effects estrus cycling fertility indices sperm parameters maternal reproductive parameters male reproductive tissue fetal viability growth external visceral morphology increase incidence rudimentary ribs aminor transient variation considered nonadverse significant developmental finding rats given day slight decreases body weight food consumption day onlymaternal effects observed rabbits adverse developmental effects noted conclusion adverse effects fertility efd observed rats doses day adverse effects efd noted rabbits doses day wiley periodicals inc
existing dominant perspectives determinants firm internationalization focused firm specific country specific factors paying less attention question clusters foster internationalization cluster firms investigate issue conducted study focused polish clusters first conceptualize impact clusters internationalization cluster firms introducing concepts propensity internationalization intensity internationalization second assess internationalization intensity clusters poland check cluster managers facilitated internationalization cluster firms results obtained show clusters play important role neutralizing liability foreignness suffered cluster entities findings confirm need internationalization related internationalization propensity emerges time cluster matures internationalization intensity higher case dense clusters combining meso microeconomic perspectives study offers holistic approach studying internationalization processes
many observers reactive violence present puzzling phenomenon offenders often report experiencing cognitive distortions event offenders may history violence yet crime scenes often described horrific violence manifests motive often seems vastly disproportionate precipitating factor reactive violence fueled intense emotions although may evident event best reconcile findings provide parsimonious coherent explanation psychoanalytic theory illuminate psychological processes may underlie reactive violence particular narcissistic injury generate impulsive aggression vulnerable individuals draw upon stanley kubrick film shining study phenomenon shining fictional horror film family tormented supernatural forces argue horror emanate paranormal sources rather found within human psychology copyright john wiley sons ltd
protein tyrosine phosphatase enzyme found negative regulator insulin leptin signaling pathway gained considerable attention medicinal chemists new therapeutic target intervention treatment type diabetes series substituted thiophen ylmethylene thiazolidine dione derivatives synthesized screened vitro protein tyrosine phosphatase inhibitory activity vivo anti hyperglycaemic activity introduction alkyl halo alkyl moiety onto amidic nitrogen thiazolidine dione ring intended enhance inhibitor enzyme affinity hence good protein tyrosine phosphatase inhibition nature interactions governs binding mode ligands inside active site protein tyrosine phosphatase studied molecular docking simulation compound found potent protein tyrosine phosphatase inhibitor synthesized compounds also shown significant lowering blood glucose level
objective oral cavity represents initial entry way oral gut indigenous colonization skin skin sts care mother holds diaper clad naked preterm infant breasts associated improved digestive function decreased stress improved survival study evaluated development oral microbial colonization repertoires health characteristics infants without sts exposure methods saliva infants weeks gestation birth collected prospectively month discharge high throughput rrna sequencing identified microbial diversity prevalence bacterial signatures correlated clinical sts non sts care results corrected gestational age cga sampling bacterial taxa demonstrated increased streptococcus signature oral repertoire maturation sts associated increased streptococcus non sts associated greater corynebacterium pseudomonas infants weeks cga neisseria acinetobacter prevalent respectively sts care associated shorter hospitalization conclusion sts care earlier gestation associated distinct microbial pattern accelerated pace oral microbial repertoire maturity
manufacturing engineering work nine japanese firms structured horizontal division labor manufacturing design engineers production process engineers contrast vertical division labor manufacturing engineers technicians three american firms production process engineers japanese firms link manufacturing engineering processes closely production processes whereas less coordination two processes occurs american firms regarding product design manufacturing engineering production processes japanese firms employees engaged downstream processes heavily involved work concerned upstream processes american firms
past three decades prevalence diabetes increased four fold coupled global obesity epidemic aging world population perfect metabolic storm brewing influence menopause exogenous estrogen progestogens must included equation review criteria diagnosing diabetes recommendations screening described reported effects menopause diabetes risk healthy women reviewed well relationship established diabetes timing menopause effects menopausal hormone therapies mht glucose control women diabetes effect mht diabetes risk menopausal women without diabetes described evidence based strategies prevent diabetes midlife women highlighted augmenting effect diabetes chronic health concerns aging women cardiovascular disease osteoporosis cancer along current recommendations screening prevention presented given current demographics today world content review may apply many one third average practitioner postmenopausal patient population
introduction personalized diets based individual genome optimize success dietary intervention reduce genetic cardiovascular disease cvd risk one challenges frequently discussed scientific community areas covered authors gathered literature based evidence nutritional genomics cvd phenotypes results research experience provide critical overview current situation using nutritional genomics tailor diets cvd prevention propose guidelines future studies implementations expert commentary hundreds studies gene diet interactions determining cvd intermediate plasma lipids hypertension etc final phenotypes stroke etc furnished top level scientific evidence claiming genetic effect cardiovascular risk deterministic modified diet however despite many results obtained still gaps practically applying personalized diet design specific genotypes hence better systemization methodological improvement new studies required obtain top level evidence allow application future precision nutrition medicine authors propose several recommendations tackling new approaches applications
dopamine camp regulated phosphoprotein kda darpp play essential roles dopamine transmission striatum suggested link exists muscarinic acetylcholine receptors machrs darpp signaling molecular mechanisms mediating relationship elucidated predominant machrs subtypes striatum study investigated functions two receptors particularly regulating camp production darpp phosphorylation rat striatal medium spiny neurons msns used time resolved fluorescence resonance energy transfer immunofluorescence confocal microscopy western blot assays cultured intact msns confirmed muscarinic receptors highly expressed notably receptors expressed receptors portion cultured msns nonselective muscarinic agonist oxotremorine slightly enhanced camp production effect independent receptors however directly participated darpp phosphorylation phosphorylating darpp thr cdk site concomitantly dephosphorylating darpp thr pica site virtually cultured msns whereas apo phosphorylated darpp thr thr induced time dependent increase darpp phosphorylation thr accompanied increased cdk activity specifically elevated immunoreactivity phospho darpp thr detected receptor expressing msns genetic knockdown pharmacologic inhibition receptors receptor selective antagonist decreased induced darpp thr phosphorylation msns results indicate muscarinic receptor plays critical role modulating phosphorylation darpp thr msns results suggest receptor activation acts antagonistically dopamine like receptors within striatum indicate receptors may potential target treatment parkinson disease relevant central nervous system disorders published elsevier ltd
paper focused optimization based design methodology application pid controller restructured competitive electricity market environment agc problem paper compares two search algorithms designing pid controller used agc multiarea power system optimal parameters pid controller determined use imperialist competitive algorithm ica deregulated scenario considered develop model multiarea agc scheme paper presents ica tuned pid ica pid controller optimally regulate generators output provide best dynamic response frequency tie line power load perturbation performance proposed controller checked area thermal power system area thermal hydro power system consideration generation rate constraint grc results obtained ica pid controller genetic algorithm tuned pid controller compared basis performance parameters settling time oscillations seen ica pid controller shows better performance compared pid controller elsevier rights reserved
background purpose skin care practices radiotherapy patients complicated dosimetric concerns study measures effect skin dose various topical agents dressings materials methods superficial doses measured topical agents dressings three clinical materials reference dose measured using mosfet detector polymethyl methacrylate slab photon beams source surface distance results relative skin dose reference materials thermoplastic mask bolus bolus realistic application topical agent relative skin doses dry dressings yielded relative dose two wet dressings yielded higher relative doses conclusions clinically relevant conditions cream gel dry dressing increased skin dose beyond seen thermoplastic mask dressings soaked water produced less skin dose bolus may unacceptable wet dressings place majority treatment course results suggest skin care practices limited dosimetric concerns using photon beam
collaborative anomaly detection cad emerging field network security academia industry attracted lot attention due limitations traditional fortress style defense modes even though number pioneer studies conducted area concern universality issue work focuses two aspects first unified collaborative detection framework developed based network virtualization technology purpose provide generic approach applied designing specific schemes various application scenarios objectives second general behavior perception model proposed unified framework based hidden markov random field spatial markovianity introduced model spatial context distributed network behavior stochastic interaction among interconnected nodes algorithms derived parameter estimation forward prediction backward smooth normality evaluation global network situation local behavior numerical experiments using extensive simulations several real datasets presented validate proposed solution performance related issues comparison related works discussed
anolyte acidification drawback restricting electricity generation performance buffer free microbial fuel cells mfc paper small amount alkali treated anion exchange resin aer placed front anode kcl mediated single chamber mfc slowly release hydroxyl ions neutralize ions generated anodic reaction two running cycles short term alkaline intervention kcl anolyte promoted proliferation electroactive geobacter enhanced self buffering capacity kcl aer mfc kcl anolyte kcl aer mfc increased became stable running cycle compared kcl mfc short term alkaline intervention maximum power density max kcl aer mfc increased slightly lower pbs mfc coulombic efficiency kcl aer mfc increased already close pbs mfc results paper indicate short term alkaline intervention anolyte effective strategy promote performance buffer free mfcs elsevier rights reserved
intestinal disorders often occur inflammation dysmotility however drugs simultaneously improve intestinal inflammation occurring dysmotility rarely reported atractylodin widely used herbal medicine used treat digestive disorders present study designed characterize effects atractylodin amelioration jejunal inflammation occurring dysmotility constipation prominent diarrhea prominent rats results indicated atractylodin reduced proinflammatory cytokines tnf alpha beta plasma inhibited expression inflammatory mediators inos kappa jejunal segments rats results indicated atractylodin exerted stimulatory effects inhibitory effects contractility jejunal segments isolated rats respectively showing contractile state dependent regulation atractylodin induced contractile state dependent regulation also observed using rat jejunal segments low high contractile states respectively pairs low high contractile states atractylodin regulated decreased phosphorylation kda myosin light chain protein contents myosin light chain kinase mlck mlck mrna expression jejuna segments rats regulated increased parameters rats taken together atractylodin alleviated rat jejunal inflammation exerted contractile state dependent regulation contractility jejuna segments isolated rats respectively suggesting potential clinical implication ameliorating intestinal inflammation occurring dysmotility
paper reviews discusses multiple sociological psychological neurological risk factors associated violent crime proposes self compassion indicator positive mental health common link among variables cross disciplinary findings implicated neurological abnormalities resulting exposure violence low self control lack social bonds self esteem violent criminality paper contends self compassion associated variables discusses current findings provide evidence link self compassion violent crime furthermore paper discusses example intervention involves self compassion finally paper discusses implications link self compassion violent crime risk factors associated violent crime elsevier ltd rights reserved
nucleotide binding oligomerization domain like receptors nlr pattern recognition receptors used provide rapid immune response detecting intracellular pathogen associated molecules loss nlr activity implicated genetic disorders disruption adaptive immunity chronic inflammation one nlr protein nod frequently mutated crohn disease inflammatory disease gastrointestinal tract three commonly occurring associated nod mutations lfs clustered near regulatory domain leucine rich region lrr lowers activity nod response muramyl dipeptide mdp lrr also ligand binding domain suggests mutations either affect binding mdp molecule responds ligand binding model role ligand dependent activation nod used homology modeling map residue interface oligomerization domain lrr show peptide derived nod binds lrr vitro upon expressing importing peptide hek expressing nod increase mdp dependent nod activity study thus suggests mutation interferes conformational changes needed mdp binding activation cell biochem wiley periodicals inc
introduction coccidioidomycosis endemic fungal infection caused soil dwelling fungi coccidioides species coccidioidal infections may asymptomatic two thirds infected persons pulmonary coccidioidomycosis common form symptomatic infection fluconazole antifungal agent typically used treat pulmonary coccidioidomycosis azoles amphotericin products may prescribed treat nuanced aspects coccidioidomycosis areas covered review discusses current literature regarding medical treatment options including various triazoles amphotericin products addition discuss uncomplicated complicated pulmonary infections sequelae approach managing coccidioidomycosis certain populations patients pregnant women transplant recipients individuals infected human immunodeficiency virus recipients tumor necrosis factor inhibitors expert commentary symptomatic coccidioidomycosis present physicians number challenges including lack sensitivity specificity diagnostic tests lack standard treatment approach patients infection ongoing future clinical trials determine optimal diagnostic therapeutic prophylactic approaches particularly patients comorbid conditions
purpose brief intervention reduce cannabis promising technique could adapted use primary care well studied setting tested efficacy brief intervention conducted general practitioners among cannabis users aged years methods performed cluster randomized controlled trial general practitioners france intervention consisted interview designed according frames feedback responsibility advice menu empathy self efficacy model control condition consisted routine care results general practitioners screened followed young cannabis users year significant difference intervention control groups median number joints smoked per month among users difference favor intervention among nondaily users months intervention associated favorable change baseline number joints smoked among users younger age smoking fewer joints per month conclusions findings suggest brief intervention conducted general practitioners french young cannabis users affect use overall however strongly support use brief intervention younger users moderate users
aims study biomarkers systemic inflammation platelet endothelial activation thrombosis tunnel construction workers tcw biomarkers blood fatty acids measured blood tcw referents baseline towards end follow days work period absent work days baseline air samples collected personal sampling personal thoracic air samples showed geometric mean particulate matter alpha quartz concentrations respectively arithmetic mean concentration elemental carbon confidence interval concentration pro inflammatory cytokine tnf alpha decreased baseline follow among tcw also platelet activation biomarkers selectin cdl decreased significantly respectively icam concentrations increased significant alterations observed among referents assessed paired sample test unbeneficial alterations blood fatty acid composition observed baseline follow mainly among referents tcw slightly reduced systemic inflammation platelet activation although highly exposed particulate matter alpha quarz diesel exhaust might due increased physical activity exposure period slightly increased icam may indicate monocyte recruitment lungs diet substantially altered towards less beneficial fatty acid profile
study aimed comparing various diets predicted induce different stimulations cecal microbial activity young rabbit fed libitum age diet enriched rapidly fermentable fiber expected stimulate cecal microbial activity rff group control diet standard composition group iii control diet tiamulin apramycin antibiotics expected inhibit microbial activity group total rabbits used litters weaned age vivo digestibility trial performed rabbits age housed individual metabolic cages feed intake growth rates lower rff group compared group adfi adg lower weight significant difference found adg final rff groups rff diet allowed better ratio postweaning digestion soluble fiber total dietary fiber minus ndf greater rff group diet positive effect postweaning morbidity rate affect mortality rate health risk index morbidity mortality conversely rff diet appeared reduce mortality rate compared diet especially age concerning cecal microbial activity supply rff diet increased cecal vfa concentrations lowered vfa pattern affected dominance acetate rff group groups instead butyrate groups respectively antibiotics addition group reduced vfa concentration weaning age without changing fermentation pattern conclusion early intake rff young rabbits stimulated cecal microbial activity reduced voluntary feed intake leading reduced ratio
evaluate association reproductive events development oesophageal cancer searched relevant studies using electronic databases pubmed isi web science study specific relative risks corresponding confidence intervals analyses used multiple summary relative risk srr estimates calculated carried subgroup analyses used meta regression techniques explore potential sources heterogeneity sensitivity analysis carried identify whether pooled results influenced individual studies publication bias assessed begg funnel plots egger regression asymmetry test fourteen studies eligible inclusion meta analysis summarizing total oesophageal cancer cases found age menopause srr hormone replacement therapy srr association decreased risk oesophageal cancer similar result obtained parity srr ever breastfeeding srr contrast postmenopausal status associated increased risk srr statistically significant link found exposures meta analysis supports substantial influence reproductive factors could causally linked oesophageal cancer copyright wolters kluwer health inc rights reserved
decentralized monitoring alarming systems attractive alternative centralized architectures distributed sensor nodes smart grid distribution network closer observed event global remote observer controller improves visibility response time system moreover distributed system local problems may also handled locally without overloading communication network paper studies alarming distributed computing perspective two fundamentally different scenarios duty duty model alarming system sensor network consisting set distributed nodes performing local measurements sense events order avoid false alarms sensor nodes cooperate escalate event raise alarm number sensor nodes sensing event exceeds certain threshold duty scenario nodes affected event actively help communication process duty scenario non event nodes inactive present analyze algorithms minimize reaction time monitoring system avoiding unnecessary message transmissions investigate time message complexity tradeoffs different settings also shed light optimality algorithms deriving cost lower bounds distributed alarming systems
prolongation activated partial thromboplastin time aptt prothrombin time international normalized ratio inr correlates poorly plasma concentrations direct oral anticoagulant agents doacs including direct thrombin direct inhibitors repeatedly demonstrated patients normal aptt inr therapeutic plasma concentration doac clinicians longer rely normal aptt determine anticoagulated patient safe undergo invasive procedure laboratory scientists need play key active role educating clinicians limitations aptt patients doac prophylaxis therapy
although intelligence theoretically evolve help animals solve specific types problems posed environment unclear environmental challenges favour enhanced cognition general intelligence evolves along domain specific cognitive abilities social intelligence hypothesis posits big brains great intelligence evolved cope labile behaviour group mates exploited remarkable convergence social complexity cercopithecine primates spotted hyaenas test predictions social intelligence hypothesis regard cognition brain size behavioural data indicate considerable convergence primates hyaenas respect social cognitive abilities moreover compared hyaena species spotted hyaenas larger brains expanded frontal cortex predicted social intelligence hypothesis however broader comparative study suggests domain general intelligence carnivores probably evolve response selection pressures imposed specifically social domain cognitive buffer hypothesis suggests general intelligence evolves help animals cope novel changing environments appears offer robust explanation general intelligence carnivores hypothesis invoking selection pressures imposed strictly sociality foraging demands
owing various advantages conventional drying systems microwave drying technology widely applied vast industrial applications microwave drying especially high moisture content products fruits vegetables temperature increase dramatically since responsive microwave absorption characteristics materials may change uncontrolled temperature result thermal burning non uniform temperature distribution treated materials ensure effective control without material degradation paper propose automatic phase controlled magnetron driver based temperature detection low cost non contact infrared temperature measurement implemented evaluated microwave environment objective proposed control automatically control power output magnetron according actual product temperature hardware component selections software flowchart described feedback control algorithm based microcontroller arduino mega also presented details experimental results proposed automatic temperature control microwave drying system investigated verified effectiveness proposed control system
publication presents computer method segmenting microcalcifications mammograms makes use morphological transformations composed two parts first part detects microcalcifications morphologically thus allowing approximate area occurrence determined contrast improved noise reduced mammograms second part watershed segmentation microcalcifications carried study carried test set containing rois pixels size taken mammograms digital database screening mammography ddsm including cases showing malignant lesions cases showing benign ones experiments carried yielded following average values measured indices similarity index overlap fraction overlap value extra fraction average time executing steps methods used single roi amounted
provide comprehensive account recent advances biomedical image analysis classification two complementary imaging modalities terahertz thz pulse imaging dynamic contrast enhanced magnetic resonance imaging dce mri work aims highlight underlining commonalities data structures common multi channel data fusion framework developed signal pre processing datasets discussed briefly taking consideration advances multi resolution analysis model based fractional order calculus system identification developments statistical signal processing using principal component independent component analysis also considered algorithms developed independently thz pulse imaging dce mri communities scope place common multi channel framework provide better software standardization pre processing noising stage comprehensive discussion feature selection strategies also provided importance preserving textural information highlighted feature extraction classification methods taking consideration recent advances support vector machine svm extreme learning machine elm classifiers complex extensions presented outlook clifford algebra classifiers deep learning techniques suitable types datasets also provided work points toward direction developing new unified multi channel signal processing framework biomedical image analysis explore synergies sensing modalities inferring disease proliferation elsevier ireland ltd rights reserved
loop stability compensation technique continuous time common mode feedback cmfb circuits presented miller capacitor nulling resistor compensation network provide reliable stable operation fully differential operational amplifier without performance degradation amplifier designed cmos technology achieves simulated performance open loop gain ghz unity gain frequency degrees phase margin also loop gain bandwidth phase margin cmfb mhz degrees respectively
paper shows another way deal speed control motor two nonlinear controllers one sliding mode control fuzzy gain scheduling pid characterize another control structure essentially configuration procedure smc fuzzy gain scheduling pid controller consolidated switching system chosen fuzzy supervisory system sliding mode controller acts essentially transient state fuzzy gain scheduler pid controller acts steady state new structure epitomizes favorable circumstances nonlinear controllers offer sliding mode controller provides fast rise time fuzzy gain scheduling pid controllers lessening chattering steady state simulation results show utilizing new hybrid smc fuzzy gain scheduling pid controller gives better system response far transient steady state concerned compared smc fuzzy gain scheduling pid controller applications controller parameters tuned help fuzzy logic
farming systems expose animals chronic mild stress known induce negative affective state affective state animals humans assessed behavioral cues study aimed describe effect chronic mild stress known induce negative affective state sheep health response vaccination study used lambs subjected model chronic mild stress weeks lambs reared conventional farming control group weeks stressful treatment lambs individually exposed judgment bias test assess putative stress induced pessimism weeks stressful treatment antibody immune response measured injection live vaccine challenge chlamydia abortus attenuated vaccine strain stressed lambs displayed pessimistic like perception judgment bias test revealing negative affective state stressed control animals showed different immunological reactions vaccine challenge stressed sheep lower hemoglobin concentrations higher platelet granulocyte acute phase protein concentrations antibody response induced vaccine strain different stressed control sheep results suggest negative affective state induced chronic stress treatment may induce stronger inflammatory response vaccine challenge sheep improvement animal health may achieved consideration stressors may affect emotional immunological state sheep
useful modification well known signal flow graph technique circuit synthesis described paper order obtain filters working current mode maximally variable parameters namely characteristic frequency quality factor bandwidth basic gain procedure based reciprocal conversion branch variables adjustable conversion constants obtained structures discussed detail described example current mode multifunctional active biquadratic filter today popular analogue application theoretic assumptions supported experimental results using modern functional blocks
sucker rod pump units primary means mechanized borehole oil production worldwide difficult economic conditions volatile oil prices continued growth electricity tariffs forced oil producers develop implement energy saving technologies known energy intensive process oil companies well mechanized production technological process lifting well fluid accompanied loss energy following structural elements pump plunger pair valve assemblies rod string pumping unit gearbox motor control station authors developed method determining relative energy consumption sucker rod pump units pumping unit consumes electric motor effective power required lift well fluid losses motor determined efficiency power factor exact definition loss motor difficult task due cyclic nature load cyclical nature load taken account using shape factor determined wattmetercard main factors affecting relative power consumption balanced pumping unit density water content oil stroke length frequency oscillation balance bar authors investigated dependence power downhole pumping units oil properties density water content graphic dependence energy consumption sucker rod pump units density water content well fluid built authors developed model relative energy consumption sucker rod pumps model consists subsystems effective mechanical power motor efficiency given load power consumed electrical network taking account balance pumping unit theoretical flow rate taking account practical flow rates depression productivity skin factor permeability developed methodology model relative power consumption introduced software intelligent control stations oilwell pumps
employing gender role ideology theory research investigates australian consumer attitudes towards current advertisements portraying males caregivers results experiment demonstrate consumers perceive gender role portrayals males caregivers atypical current advertising environment consumers particular hold non traditional egalitarian gender role ideology report positive attitude towards advertising challenges traditional gender role ideologies advertising depicts males caregivers suggest non traditional advertising challenges traditional gender roles provides advertisers opportunity stand however advertisers must ensure key product related message components overshadowed
leaf optical properties lops convey information relating temporally dynamic photosynthetic activity biochemistry lops also sensitive variability anatomically related traits specific leaf area sla via interplay intra leaf light scattering absorption processes therefore variability traits may demonstrate little plasticity time potentially disrupts remote sensing estimates photosynthesis biochemistry across space help disentangle various factors contribute variability lops defined baseline variation variation lops occurs across space time next hypothesized two main controls potentially disruptive baseline spatial variability photosynthetically related lops boreal forest site light environment species measured photosynthetically related lops conjunction morphological biochemical photosynthetic leaf traits summer across selected boreal tree species vertical gradients light environment conducted detailed correlation analysis disentangle spatial factors control baseline variability leaf traits resultantly lops baseline spatial variability photochemical reflectance index pri strongly influenced species lesser extent light environment baseline variability spectral fluorescence derived lops less influenced species however longer near infrared wavelengths light environment important control summary remote sensing chlorophyll fluorescence good potential detect variation photosynthetic performance across space boreal forests given reduced sensitivity species related baseline variability comparison pri results also imply spatially coarse remote sensing observations potentially unrepresentative full scope natural variation occurs within boreal forest
let lambda lambda ultraspherical pohnomial noronalioed prove inequality vertical bar vertical bar element lambda equality holds even partial results extension inequality normalized jacobi polynomials given
little doubt malassezia spp plays role atopic dermatitis may interact local skin immune responses barrier function sensitization skin colonizing yeast correlate disease activity also antifungal therapy shows beneficial effects patients however pathogenetic mechanism mutual interaction malassezia spp atopic dermatitis still remain partly unclear need investigation
human body plays central role nonverbal communication conveying attitudes personality values social interactions three experiments large open classroom setting investigated whether visibility torso located cues affects nonverbal communication similarity experiments half participants wore black plastic bag torso participants interacted unacquainted sex individual selected large class also wearing also wearing bag experiment added clear bag condition visual torso cues obscured across experiments black bag wearing participants selected partners less similar attitudes behaviors personality compared bag less clear bag participants nonverbal cues torso communicate information similarity attitudes behavior personality center body plays surprisingly central role early stage person perception attraction
paper new approach proposed design arbitrary plane filters including band pass band stop filters desired frequency response proposed method based replacing conventional resonators new form resonator made patterned plane patterned plane metal plane infinitesimal thickness parts removed introduced patterned plane supported thin low permittivity dielectric slab located longitudinally middle rectangular waveguide parallel plane design proposed filters scattering parameters structure calculated purpose coupled set electric field integral equations derived solved method moments suitable cost function defined optimized using genetic algorithm matlab tool used optimize cost function proposed method facilitates accelerates optimization process comparison full wave simulator software examples band pass band stop plane filters designed results show proposed filter comparison conventional filters advantages frequency band selectivity compactness ability adjustment desired frequency response results designed structures validated hfss simulator software
article examines causes social mechanisms anti american attitudes behavior illustrates fruitfulness theoretical approach using example germany argue anti american attitudes rooted mainly two sociopsychological functions rationalization social change projection self parts suppressed determinants social norms lack personal social contact americans strong national identity also investigate correlation anti american attitudes behavioral intentions using national sample comprehensive measure anti americanism document distribution perceptions america americans among german population explore explanatory power theoretical concepts
titanium dioxide photocatalysts prepared new synthesis method involves rapid heating short medium exposures sol gel prepared amorphous starting materials different temperatures calcination times rhse rhme series samples also synthesized using conventional calcination methods applying slow heating long exposure times shle series sets samples characterized various methods dta xrd sem tem drs toc xps techniques sedimentation experiments rhse rhme samples good crystallinity consist anatase rutile mixtures photocatalytic activity catalysts studied suspensions using phenol monuron model substrates best performance found rhme sample prepared degrees min exposure sample high activity comparable aeroxide tio reference photocatalyst substrates rhse rhme samples significantly exceeded performance shle samples loss surface groups long time calcination assumed negative effect activity shle samples due high degree aggregation particles aqueous solutions improved photocatalytic performance attributed higher level absorption light near range new economic treatment strategy could major impact materials engineering vis active photocatalysts prepared via sol gel methods especially using acetic acid aqueous solution ammonia elsevier rights reserved
present times discrimination experiences various marginalized groups tend characterized subtle acts disrespect intolerance addition traditional blatant incidents violence one newer manifestation microaggression research explored impact frequency experiencing invisibility feeling ignored overlooked owing one group membership distress among northeasterners residing delhi role individual self stereotyping moderator invisibility frequency distress relationship investigated moderation analysis suggested significant moderating effect individual self stereotyping relationship frequency experiencing invisibility acts distress experienced northeasterners words experiencing invisibility caused distress participants saw prototypical northeasterners interestingly frequency experiencing invisibility associated distress northeasterners however size relationship greater northeasterners saw typical group
positive effects incorporating electrically conductive poly ethylenedioxythiophene poly styrene sulfonate pedot pss negative electrode lithium ion capacitor lic investigated binding material styrene butadiene rubber sbr partially substituted conductive pedot pss soft carbon pedot pss exhibits enhanced capacity retention current density lowering electrical electrochemical charge transfer resistance rate capability increased increasing amounts pedot pss variation diffusivity improved electrochemical performance also reflected lic full cell configuration lic employing pedot pss delivers high current density higher measured lic bare moreover lic pedot pss retains initial capacitance even cycles results mainly attributed favourable electrical network formed incorporation pedot pss thus believe incorporation conductive pedot pss viable approach obtaining high power lics elsevier rights reserved
fresh injuries anal region concerning infants always lead suspicion sexual abuse rape described german penal code differentiation must made findings indicative acute chronic anal sexual abuse clinical forensic medicine injuries due acute anal penetration must documented expert opinion must made individual cases differential diagnosis respect alleged accidental event pre existing diseases must taken consideration demonstrate relevant findings difficulties arising assessment four cases presented
objectivethe aim study investigate bipolar patients whether affect lability associated suicidal ideation incidence year follow subtype affect lability associated suicidal ideation methoda total euthymic mildly depressed bipolar outpatients recruited french fondamental advanced centres expertise bipolar disorder divided two subgroups according occurrence suicidal ideation year follow affect lability assessed french version affect lability scale resultsbipolar patients high affect lability likely report suicidal ideation follow even adjustment age study level rapid cycling current depression level anxiety disorder lifetime history risk suicidal ideation increased level affect lability specifically propensity switch neutral elation affect anxious depressive affect inversely neutral anger affect predicted suicidal ideation conclusionreducing affective lability could become new therapeutic target suicidal prevention bipolar disorder
market led strategies growth development resulted negative externalities various stages production consumption cycle leading destruction environment negative consequences sustainable development prior emergence sustainable development economic development geared towards economic growth paid less attention externalities since vibrant competitive private sector entrepreneurship approaches tapped ghana creation jobs employment coupled factors transitioned country middle income status undue focus competitive private sector without prudent practices sustainability led exploitation use natural resources caused deforestation land degradation air water pollution soil erosion overgrazing destruction bio diversity effects estimated cost country gdp annually green entrepreneurship vital addressing challenges eradication poverty using desk study approach paper assesses ghana harness innovative potentials green entrepreneurship foster attainment sustainable development
unexpected informal recognition common workplace rarely analyzed academics existing studies generated surprising results impact selective recognition future productivity workers receive recognition increases productivity confirm results recognition form thank message show patterns hold true unexpected financial recognition low performing workers better others recognized left previous studies argued pure relative performance information revealed recognition drives effects test hypothesis treatment relative rank information show indeed case financial verbal recognition necessary induce low performers increase subsequent performance elsevier rights reserved
understanding climate change adaptation processes attention needs paid various contextual factors shape whether climate related knowledge information received acted upon actors involved study sets examine characteristics forest owners sweden information knowledge sharing networks draw upon decision making perceptions climate risks forests resilience need adaptation perceived adaptive capacity applying concept ego network analysis empirical data generated quantitative survey distributed private forest owners sweden response rate results show positive correlation even though generally weak forest owner climate perceptions network features network size heterogeneity presence certain alter groups network members actors results indicate forest owners social networks currently serve minimal function sharing knowledge climate change adaptation moreover considering fairly infrequent contact respondents alter groups timing knowledge sharing important conclusion suggest actors forest owners frequently communicate especially forestry experts providing advisory services forest owner associations companies authorities clear role communicate risks climate change opportunities adaptation peers valuable connecting information climate risks adaptation actual forest property
background angioedema condition cause cutaneous mucosal edema practically part body isolated edema intestines rather rare manifestation cause important morbidity hereditary angioedema well certain medications give rise intestinal angioedema seen rise frequency intestinal angioedema since advent angiotensin converting enzyme inhibitors ultrasound abdomen inexpensive safe easy tool help differential diagnosis case report describe case year old woman presented acute abdominal pain diagnosed intestinal angioedema due hereditary angioedema type emergency physician aware misdiagnosis lead administering wrong treatment even unnecessary surgical interventions intestinal angioedema best treated purified inhibitor icatibant ecallantide fresh frozen plasma avoided carries risk worsening symptoms elsevier inc
religion essential effect development society since impacts religious norms models behaviour establishes priorities values influences gender relations predetermines gender roles influences establishing certain traditions laws customs article review historic position russian orthodox church dominant religion russia past current status russia issues relating women russian socio cultural religious community lack research russian orthodox church influence russians particularly russian women increased religiosity russia within last decade requires study russian orthodoxy impact people lives attitude gender article provides deep analysis impact russian orthodox church image women russia argued russian national character heritage formed russian orthodox church existing gender stereotypes russia significantly impacted russian orthodox church mainly derived interpretation new testament russian orthodoxy clergy particularly gender roles perception family marriage understood compliance values russian orthodox faith faith important purpose marriage birth raising children chief responsibility duty woman care husband children considered way woman service society god
background due hormonal changes postmenopausal women prone many complications like increased cvd risk factors osteoporosis obesity mood swings urinary incontinence physical inactivity postmenopausal women leads higher risk developing cvd osteoporosis objective find correlation physical activity level bmd cardio respiratory fitness body composition post menopausal women methods postmenopausal women included detailed clinical evaluation physical activity level ipaqmets mins week bmd scores body composition bmi waist circumference bia skin fold calliper fat cardio respiratory fitness measured balke protocol vopeak min estimated correlation physical activity level bmd cardio respiratory fitness body composition analysed using pearson product moment correlation efficient spearman rho results spearman rank correlation rho ipaq peak bmi visceral fat indicating moderate positive correlation ipaq cardio respiratory fitness weak negative correlation ipaq bmi visceral fat pearson product moment correlation coefficient ipaq bmd body fat waist circumference indicating correlation value significant correlation ipaq crf bmi visceral fat conclusion moderate positive correlation ipaq cardio respiratory fitness weak negative correlation ipaq bmi visceral fat correlation ipaq bmd body fat waist circumference
objectives objectives work determine prevalence irritable bowel syndrome ibs ibs subtypes women presenting fecal incontinence treatment assess impact ibs symptoms quality life qol methods multicenter prospective cohort study women reported least monthly solid liquid mucus rome iii clinical criteria defined ibs women also self reported ibs diagnosis baseline questionnaires included following modified manchester health questionnaire fecal incontinence severity index bristol stool scale pelvic floor distress inventory pelvic floor impact questionnaire results women enrolled completed rome iii ibs questionnaires reported whether previous diagnosis ibs prevalence ibs confidence interval according rome iii ibs criteria common subtypes ibs mixed ibs diarrhea twenty four patients previous diagnosis ibs among women met rome iii ibs criteria women never diagnosis ibs women ibs reported significantly worse qol compared women without ibs despite similar severity stool consistency conclusions irritable bowel syndrome negatively affects qol affects one third women presenting care tertiary centers findings suggest assessment ibs symptoms diagnosis may important women presenting treatment
ability individuals autism spectrum disorder asd process context long debated according weak central coherence theory asd characterized poor global processing consequentlypoor context processing contrast social cognition theory argues individuals asd present difficulties social context processing complexity theory autism suggests context processing asd depend task complexity current study examined controversy two priming tasks one presenting human stimuli facial expressions presenting non human stimuli animal faces tasks presented visual targets preceded congruent incongruent neutral auditory primes local global processing examined presenting visual targets three spatial frequency conditions high frequency low frequency broadband tasks administered adolescents high functioning asd matched typically developing adolescents reaction time accuracy measured task condition results indicated individuals asd processed context human non human stimuli except one condition human stimuli processed globally target presented low frequency task demands presented condition performance deficit shown asd group result could understood terms cognitive overload findings provide support complexity theory autism extend results also demonstrate associative priming could support intact context processing human non human stimuli individuals asd autism res international society autism research wiley periodicals inc
paper proposes hardware optimized low power three stage compensated operational amplifier capability driving wide range capacitive loads ranging amplifier compensated implementing embedded capacitance multiplier compensation outer miller capacitor traditional reverse nested miller compensation rnmc feed forward stage provides unity gain bandwidth ugb greater mhz phase margin greater degrees range loads mentioned circuit power dissipation supply proposed technique uses two compensation capacitances design achieves unity gain bandwidth mhz capacitive load simulation carried cmos technology cadence virtuoso environment
background long acting injectable antipsychotics treatment options acute long term treatment patients schizophrenia previously published week randomized double blind placebo controlled clinical trial patients schizophrenia experiencing acute psychotic episode aripiprazole monthly aom produced significantly greater improvement placebo primary endpoint positive negative syndrome scale panss total score week methods examine efficacy aom across broader representation schizophrenia symptoms including agitation post hoc analysis trial carried assess change panss marder factor domains positive symptoms negative symptoms disorganized thought uncontrolled hostility excitement anxiety depression panss excited component equivalent marder factor domain uncontrolled hostility excitement plus tension item comparing differences change baseline aom placebo using mixed model repeated measures results differences treatment placebo factors statistically significant improvements seen early week maintained week thus aom supplemented oral aripiprazole first weeks showed significantly greater efficacy versus placebo acutely ill patients schizophrenia marder illness domains well agitation conceptualized panss excited component score conclusions findings indicate aom efficacious across spectrum schizophrenia symptoms acutely ill patients implications short term extension long term patient outcomes
study evaluated alveolar bone response testosterone impact resolvin rvd testosterone induced osteoblast function vivo characterization male adult rats used treatments established sub physiologic normal supra physiologic concentrations testosterone forty rats subjected orchiectomy rats received periodical testosterone injections rats received testicular sham operation four weeks surgeries rats group received subgingival ligature around lower first molars induce experimental periodontal inflammation bone loss parallel osteoblasts differentiated neonatal mice calvariae treated various doses testosterone cell lysates conditioned media used determination alkaline phosphatase osteocalcin rankl osteoprotegerin micro computed tomography linear analysis demonstrated bone loss significantly increased groups compared animals normal levels testosterone gingival expression increased group ten testosterone significantly decreased osteocalcin rankl opg levels osteoblasts significantly increased rankl opg ratio rvd partially reversed impact testosterone osteocalcin rankl opg findings suggest testosterone levels increase inflammatory bone loss male rats low testosterone predominantly increases inflammatory response high testosterone promotes higher osteoblast derived rankl opg ratio proresolving mediator rvd ameliorates testosterone derived downregulation osteocalcin rankl opg primary murine osteoblasts suggesting direct role inflammation osteoblast function
aims objectives critically appraise available literature summarise evidence relating adolescent mothers use social networking sites terms social support social capital may provide identify areas future exploration background social networking sites demonstrated provide social support marginalised individuals provide psycho social benefits members groups adolescent mothers risk social marginalisation anxiety disorders depressive symptoms poorer health educational outcomes children social support shown benefit adolescent mothers thus online mechanisms require consideration design review original research articles method key terms boolean operators identified research reports across year timeframe pertaining area enquiry cinahl cochrane library medline scopus eric proquest psychinfo web science health collection informit google scholar databases eight original research articles met inclusion criteria review findings studies demonstrate adolescent mothers actively search health information using internet social networking sites social support social capital attributed use specifically created online groups within targeted health interventions use message board forum pregnant parenting adolescents also demonstrates elements social support studies date pertaining adolescent mothers use globally accessible social networking sites terms social support provision related outcomes conclusions investigation warranted explore potential benefits adolescent mothers use globally accessible social networking sites terms social support provision social capital may provide
complex span paradigm one influential widely used instruments measuring working memory capacity wmc report results four experiments designed explore feasibility obtaining valid estimates wmc online explored relationships complex span tasks fluid intelligence lab web using new platform called online working memory lab owl owl universally accessible across computer operating systems functions local remote contexts allowing researchers sample diverse subjects practically anywhere experiments showed complex span failed predict remembered stimuli letters tests taken online increased predictive validity test battery experiments replacing letters memory stimuli difficult write unproctored setting work describes recent attempts measure working memory capacity wild
let set points integer grid maximal layer set points dominated point considering axes parallel query rectangle design adaptive space efficient data structure using layers maxima iterative maximal layers reporting points boolean data structure needs linear space queried time log epsilon log epsilon number layers maxima points query rectangle size output epsilon small arbitrary constant range also worst case query time data structure loge model computation word ram size word log epsilon elsevier rights reserved
study examined spanish young people gender stereotyped beliefs attitudes people working field information communications technology ict purpose positive negative neutral perceptions associated characteristics workers also analyzed likewise use masculine feminine neutral expressions describe professionals explored existence gender differences aspects also investigated students catalonia girls enrolled last course junior secondary education mean age years old participated survey close open ended questions content analysis responses open ended question indicated boys girls held several stereotypical beliefs ict professionals highly male dominated field also reported counter stereotypical beliefs expected stereotypical beliefs described masculine portrayal ict workers contrary expectations students portrayals people working ict either positive neutral negative likewise opposite predictions young males show positive attitudes towards ict professionals girls fact girls boys evaluated positively negatively different descriptive aspects associated ict professionals support expectations boys girls referred masculine role models working ict gender differences observed type characteristics associated ict professionals however young females likely offer feminine references professions ict tool rather object work theoretical practical implications findings within context spain discussed
idiopathic pulmonary fibrosis ipf rare form chronic progressive fibrosing interstitial pneumonia unknown cause aim cross sectional study assess prevalence osteoporosis fragility fracture population adults ipf identify whether possible clinical pulmonary function parameters may associated increased bone fragility ipf patients mean age years measured bone mineral density bmd lumbar spine femoral neck entire hip moreover presence vertebral fractures lateral chest ray study evaluated vertebral fracture burden quantified using spinal deformity index sdi expected osteoporosis significantly frequent females respect males respectively whereas fractures prevailed males respect females respectively positive correlations bmd skeletal sites respiratory parameters particular fvc dlco bmd femoral sub regions moreover compared average dlco measure values sdi score higher patients lower values dlco study shows high prevalence fragility vertebral fractures ipf patients especially males moreover vertebral fracture burden associated worsening fvc dlco therefore evaluation bone status recommended especially patients candidates lung transplantation
prior studies indicate substantial link maternal depression early child health give limited consideration direction relationship context occurs sought create contextually informed conceptual framework relationship semi structured interviews women lived experience caring hiv infected child coping depression anxiety symptoms caregivers explained role raising healthy children complex complicated poverty stigma isolation caregivers discussed effects mental health child well primarily emotional behavioral explained looking child could bring distress particularly unable provide desired care sick children findings suggest need investigation reciprocal effects child sickness caregiver wellness integrated programs holistically address needs hiv affected families
pilot balloon observatories india meteorological department avid using hand held data logger hhdl manufactured sameer compute upper air data since hhdl sleek microcontroller based battery operated unit accepts information numeric keypad pertaining ascent raw file generation pilot balloon data processing raw file transferred computer system input file based pibal computation software software generates pibal messages similar hhdl addition national data centre ndc data format monthly climate case failure hardware hhdl based pibal computation software used therefore overcome problem based pibal data keying software developed using visual sharp new software developed creates input file similar hhdl tested based pibal computation software works successfully alternate case failure hhdl hardware accessories
background evidence literature suggests impairment social cognition schizophrenia theory mind tom defined one ability understand others wishes beliefs intentions psychological states thereby judge others behavior essential component social cognition however limited studies social cognition especially tom adolescent onset schizophrenia aos current study aims investigate tom abilities adolescent schizophrenia according various tom subcomponents cognitive tom affective tom various tom orders first order second order methods study examines tom adolescent schizophrenic patients healthy adolescents using yoni task faux pas recognition test assess affective cognitive tom abilities results yoni task patients aos showed differences tom abilities either different order different conditions faux pas recognition task results revealed aos patients always able recognize faux pas understand complicated emotions faux pas scenario furthermore indicated correlation analysis neither cognitive tom affective tom related patients symptoms disease duration dose medication intelligence quotient conclusion findings showed aos impairment performance tom tasks seemed impairment second order tom serious moreover deficits largely independent symptom clusters disease duration dose medication speculated tom dysfunction may hallmark adolescent schizophrenia
industrial internet things iiot emerging new communication paradigm class low power wireless networks used critical applications industrial process monitoring automation networks receiving significant attention standardization bodies lightweight protocol stack built top time slotted channel hopping tsch technology available iiot devices usually energy constrained thus worldwide scientific community spending lot efforts designing new energy saving communication protocols tsch enabled networks nevertheless even energy consumption mainly due radio communications transmission unneeded data protocol overhead non optimized communication patterns implementation iiot protocol suite real platforms may introduce unpleasant waste energy aim work experimentally measure energy consumption tschenabled platforms specifically telosb motes different system configurations two investigated operating systems openwsn contiki obtained results demonstrate openwsn always registers lower energy consumption thus emerging promising protocol implementation upcoming energy efficient iiot systems
introduction myelofibrosis complex heterogeneous disease continues challenge treating clinician ruxolitinib first jak inhibitor approved delivers reduction splenomegaly disease related symptoms likely prolongs survival jak inhibitors trialled combination appear alleviate anaemia thrombocytopenia deepen response however number patients may gain benefit lose response able tolerate ruxolitinib areas covered remains need alternative agents myelofibrosis patients jak inhibitors failed tolerable discuss different therapeutic options currently available explore pomalidomide therapeutic option anaemic thrombocytopenic patients without splenomegaly expert opinion responses documented clinical trials suggest pomalidomide efficacy might variable limited benefit improving constitutional symptom burden reversing disease process however number phase trials demonstrated pomalidomide safe efficacious option managing splenomegaly reducing transfusion requirements minority improving platelet number discuss pomalidomide currently approved use multiple myeloma potential alternative challenging myelofibrosis patient thrombocytopenia anaemia exist
obesity reached epidemic proportions past decades research beginning focus behavioral cognitive mechanisms may contribute rise obesity youth emerging adults based previous models obesity current research activation approach motivational states predicted impulsive individuals individuals high body dissatisfaction would demonstrate narrowing attentional focus response food cue exposure participants completed task assessing attentional breadth response food non food cues followed measures eating behaviors delay discounting measure impulsive decision making findings revealed delay discounting interaction bmi body dissatisfaction predicted narrowing attentional scope following presentation food cues implications findings might account link impulsivity body dissatisfaction maladaptive eating discussed elsevier ltd rights reserved
screening standardized manner osteoporosis non vertebral fracture patients aged older independently gender level trauma energy yielded indication osteoporotic therapy every fourth male high energy fracture patient purpose study aimed identify rate osteoporosis patients genders fracture independently underlying level trauma energy methods random cohort patients aged older non vertebral fractures participated standardized diagnostic protocol evaluate indication treatment osteoporosis number needed screen nns univariate multivariate analysis well correlation testing performed determine statistical relationships significance set results fracture patients mean age years female male one hundred nineteen patients sustained high energy fractures hefs low energy fractures lefs twenty eight percent males females qualified osteoporotic densitometry dual energy ray absorptiometry dxa resulting nns women men indication treatment osteoporosis increased nns females males fracture risk assessment tool frax included diagnostics dxa frax regard energy trauma nns treatment following dxa frax lef hef subgroup analysis revealed hef males within decennia nns around comparable females twice high lef patients conclusions preliminary findings appear confirm pragmatic approach screening standardized manner osteoporosis non vertebral fracture patients aged older independently gender level trauma energy
nowadays many companies institutions need fast reliable identification systems able deal large databases fingerprints among used biometric traits identification current literature fingerprint matching algorithms focused efficiency whilst others based accuracy paper propose flexible dual phase identification method called dpd dff combines two fingers two matchers within hybrid fusion scheme obtain fast accurate results different alternatives designed find trade runtime accuracy tuned single parameter experiments show dpd dff obtains competitive results comparison state art score fusion techniques especially dealing large databases impostor fingerprints elsevier rights reserved
paper conduct research higher vocational student status management perspective procedural justice main task higher vocational education develop production construction management service first line high skilled applied talents higher vocational colleges must according talent market demand set professional training target teaching content talent market applied talents high skill specific requirements embodied culture type specification teaching content one status student point upon passing entrance examination official admission admission formalities basic accordance relevant provisions report qualified students registration management refers school accordance relevant state policies laws regulations students entrance graduation management implementation training process research proposes new perspective issues necessary
probe role protein arginine methyltransferase prmt regulating inflammation cell proliferation migration invasion fibroblast like synoviocytes flss patients rheumatoid arthritis flss separated synovial tissues sts patients osteoarthritis inhibitor prmt epz short interference rna sirna prmt used inhibit prmt expression standard protein measured western blot immunofluorescence excretion genetic expression inflammatory factors respectively estimated enzyme linked immunosorbent assay elisa real time polymerase chain reaction pcr migration invasion vitro detected boyden chamber assay flss proliferation detected brdu incorporation increased prmt discovered sts flss patients flss level prmt regulated stimulation tnf inhibition prmt epz sirna mediated knockdown reduced production proliferation flss addition inhibition prmt decreased vitro migration invasion flss furthermore epz restrained phosphorylation kinase well nucleus transsituation well akt flss prmt regulated production inflammatory factors cell proliferation migration invasion fls mediated akt pathways data suggested targeting prmt prevent synovial inflammation destruction might promising therapy
work design methodology synchronous reluctance motors synrm presented methodology focused maximizing average torque also takes account torque ripple presented methodology parameterizes rotor function certain design variables define arrangement iron segments flux barriers change one design variables involves change rotor geometry resulting new machine design methodology based systematically change design variables machine electromagnetic behavior performance motor evaluated finite elements models fem
mindful construal diaries found assist weight regulation long term intervention current study attempted expand previous findings testing consideration priming questions within diary instead filling answers investigated levels state mindfulness state self compassion state anxiety observational trial pre postintervention forty five participants completed state mindfulness state self compassion state anxiety scales meal asked read consider mindful concrete construal diary questions results illustrate state mindfulness state self compassion state anxiety levels significantly improved increased mindfulness self compassion decreased anxiety participation findings provide evidence diaries might work supporting weight regulation suggest another method making eating mindful current findings limitations recommendations future research discussed
inherent uncertainty factors technology creativity evolving software development major challenge management software projects address challenges project manager addition examining project progress may cope problems increased operating costs lack resources lack implementation key activities better plan project software cost estimation sce models fully cover new approaches lack coverage causing problems consumer producer ends order avoid problems many methods already proposed model based methods familiar solving technique noted model based methods use single formula constant values methods responsive increasing developments field software engineering accordingly researchers tried solve problem sce using machine learning algorithms data mining algorithms artificial neural networks paper hybrid algorithm combines coa cuckoo optimization nearest neighbors knn algorithms used called composition algorithm runs six different data sets evaluated based eight evaluation criteria results show improved accuracy estimated cost
fast global adoption materials genome initiative mgi scientists engineers faced need conduct sophisticated data analytics large datasets extract knowledge used modeling behavior materials raises new problem materials scientists create foster interoperability share developed software tools generated datasets microstructure informed cloud based platform micloud developed addresses need enabling users easily access insert microstructure informatics computational tools predict performance engineering products accounting microstructural dependencies manufacturing provenance platform extracts information microstructure data employing algorithms including signal processing machine learning pattern recognition computer vision predictive analytics uncertainty quantification data visualization interoperability capabilities micloud various web based applications demonstrated case study analyzing tialv microstructure data via automatic identification various features interest quantifying characteristics used extracting correlations causations associated mechanical behavior yield strength cold dwell debit etc data recorded two methods backscattered electron bse imaging extracting spatial morphological information alpha beta phases electron backscatter diffraction ebsd extracting spatial crystallographic morphological information microtextured regions mtrs alpha phase extracting reliable knowledge generated information requires data analytics large amount multiscale microstructure data necessitates development efficient algorithms associated software tools data recording analysis visualization interoperability tools superior effectiveness cloud computing approach validated featuring several examples use alpha beta titanium alloys based superalloys reflecting anticipated computational cost time savings via use web based applications implementations microstructure informed integrated computational materials engineering icme
examined year olds hong kong usa evaluations hypothetical scenarios mothers sought control personal domain events prohibiting persuading shaming child scenarios also varied description personal events either essential peripheral self compliance endorsed least emotions attributed actors positive mothers gently persuaded endorsed emotion attributions negative mothers prohibited personal choices evaluations compliance associated emotions shaming fell mothers described gently persuading young children chinese children gave priority personal choices acts described essential rather peripheral self based personal reasons mothers described shaming noncompliance increased age along pragmatic justifications choices particularly events essentialized positive emotions response shaming also increased age differentially chinese american children
gut microbiota largest organ human body although growth bacteria colony forming unit cfu per milliliter culture upper gut aspirate used diagnosis small intestinal bacterial growth sibo cfu considered suggest diag nosis particularly colonic type bacteria present upper gut although neither sensitive specific hydrogen breath tests widely used diagnose sibo rifaximin best treatment sibo due broad spectrum lack systemic absorption safety profile
anorexia nervosa eating disorder mainly affecting women lifetime prevalence run chronic course effective pharmacotherapy lacking hypothesized progesterone type glucocorticoid receptor antagonist mifepristone might useful well known hypothalamo pituitary adrenal axis hpa activated even secondary eating disorder active hpa axis may contribute maintaining neuroendocrine emotional behavioral effects observed specifically suggested hpa axis interacts limbic structures including insular prefrontal cortices uphold changes interoceptive emotional awareness seen proposed mifepristone reverses effects acting limbic regions conclusion theoretical efficacy mifepristone improving symptoms tested randomized clinical trials elsevier inc rights reserved
calculation energy protein doses critically ill patients still matter controversy years nutrition support total amount nutrients delivered patients calculated based expert recommendations calculation based administration nonprotein calories one attempt ameliorate catabolic response avoid weight loss new evidence suggests protein delivery important intervention improve clinical metabolic outcomes article describes metabolic rationale new evidence supporting change approach metabolic support critically ill proposing physiological based intervention supported recognition ancillary characteristics metabolic response trauma injury moderate dose calories around kcal delivery protein appears new recommendation many hypercatabolic patients first week following injury
introduction differentiated thyroid carcinoma dtc follow thyroidectomy radioiodine ablation performed mainly thyroglobulin diagnostic iodine whole body scan dxwbs sonography patients undetectable thyroid bed uptake ablation decision making regarding need retreatment still controversial methods study enrolled dtc patients undetectable small thyroid residue six month dxwbs following first radioiodine ablation patients detectable high tgab suspicious neck lymphadenopathy sonography metastasis excluded ninety four patients placed two groups cohort radioiodine retreatment group versus observation untreated group six months clinical outcome compared evaluating dxwbs tgab sonography results dxwbs showed sustained thyroid remnant retreated patients untreated group revealed negative dxwbs next period follow also cases retreatment group cases observation group revealed additional finding local faint rai uptake including detectable serum rising tgab suspicious ultrasound finding favoring significant difference outcome well relative risk new finding incidence treated untreated patients relative risk conclusion regarding sonologic laboratory follow evidences rai retreatment shows significant advantage observation dtc patients negative remnant positive dxwbs addition residual thyroid tissue completely disappeared one third patients without retreatment
background coccidioidomycosis fungal infection usually presents primary lung infection fungus endemic southwest united states america northern mexico parts central south america infection rare outside areas however patients develop disseminated infection lie dormant several years present travelers report first case extra pulmonary coccidioidomycosis non immunocompromised individual denmark case presentation year old danish woman presented emergency department abdominal pain computed tomography scan ultrasound examination pelvis raised suspicion salpingitis laparoscopy exposed necrotic salpinx several small white elements resembled peritoneal carcinomatosis histological workup however determined suffered disseminated coccidioidomycosis patient lived years las vegas united states america years prior memory lung infection time conclusions disseminated coccidioidomycosis rare non immunocompromised individuals patient case underwent several rounds vitro fertilization treatment years admittance suspect hormonal treatment combination low dose prednisolone may triggered reemergence disease present literature support
continuous monitoring system cms model presented new improved capabilities system based actual real time configuration system existing risk scoring models assume damage potential estimated systems owner thus rejecting information relying technological configuration assumption underlying research based users ability estimate business impacts relating systems external interfaces use regularly business activities unable assess business impacts relating internal technological components according proposed model systems damage potential calculated using technical information systems components using directed graph graph incorporated common vulnerability scoring systems cvss algorithm produce risk scoring measures framework presentation includes system design damage potential scoring algorithm design illustration scoring computations
flow muck cuttings face cutterhead cutting chamber screw conveyor determines pressure profile excavated soil well impact wear related components soft ground tunneling machine paper discusses use computational fluid dynamic cfd simulate flow characteristic conditioned soil screw conveyor earth pressure balance epb tunnel boring machine simulation conditioned soil assumed behavior bingham plastic fluid back analysis method conjunction cfd modeling used calculate rheological properties soil set known screw conveyor torque read outs machine operating seattle error torque values simulation results actual field data range illustrate cfd method simulate soil movement screw conveyor epb machines results also indicates approach used optimize machine design minimize torque wear well optimizing machine operating parameters tunneling operation improve productivity better control face pressure elsevier ltd rights reserved
background clinically diagnosed eating disorders may adverse cardiometabolic consequences including overweight obesity high blood pressure however link problematic eating attitudes early adolescence lead disordered eating behaviors future cardiometabolic health knowledge unknown objective assessed whether variations midchildhood eating attitudes influence future development overweight obesity high blood pressure design children participated promotion breastfeeding intervention trial probit included participants response rate completed children eating attitudes test cheat age measured adiposity blood pressure ages assessed whether cheat scores percentile indicative problematic eating attitudes compared scores percentile age associated new onset overweight obesity high systolic blood pressure high diastolic blood pressure midchildhood early adolescence results controlling baseline sociodemographic confounders observed positive associations problematic eating attitudes age new onset obesity new onset high systolic blood pressure new onset high diastolic blood pressure age controlling body mass index age problematic eating attitudes remained positively associated new onset obesity however associations new onset high blood pressure attenuated new onset systolic diastolic blood pressure respectively conclusions problematic eating attitudes midchildhood seem related development obesity adolescence relatively novel observation potentially important public health implications obesity control
size microstructural features long known determine strength materials hall petch effect grain size recently importance size structure thin foil wire pillar loaded volume indentation recognised many phenomenological theories proposed account size effect experimental data high accuracy reported copper wire torsion distinguish size effects grain size structure size elastic limit flow stress low plastic strain data compared less accurate data similar wires tension size effects shown arise first principles analysis dislocation behaviour exploiting slip distance theory conrad together forest taylor work hardening theory modifications theories account finite structure size resulting theory compatible concepts dislocation starvation strain gradient plasticity size effect elastic limit due constraint size puts dislocation curvature size effect flow stress due constraint size puts dislocation mean free path fate dislocation moved
despite increasing evidence subchondral bone contributes osteoarthritis pathogenesis little known local changes bone structure compared cartilage degeneration study linked structural adaptation subchondral bone histological grade twenty five osteochondral samples macroscopically different degeneration prepared tibiae patients samples scanned micro computed tomography conventional structural parameters novel parameters based local patterns analyzed subchondral plate trabecular bone subsequently samples processed histology evaluated oarsi grade bone parameter oarsi grade compared assess structural adaptation bone severity addition thicknesses cartilage calcified cartilage subchondral plate analyzed histological sections compared subchondral bone plate thickness increasing oarsi grade subchondral plate became thicker along decreased specific bone surface change tissue mineral density histological analysis showed subchondral plate thickness also includes calcified cartilage entropy local patterns increased severity reflecting higher tissue heterogeneity trabecular compartment bone volume fraction trabecular thickness number increased oarsi grade trabecular separation structure model index decreased also elevation local patterns became longitudinal subchondral plate axial transverse trabecular bone increasing oarsi grade study demonstrates possibility radiological assessment severity structural analysis bone authors journal orthopaedic research published wiley periodicals inc
preschoolers sophisticated understanding reward punishment investigated whether children spontaneously correct unfair punishments across two experiments year olds engaged block tower building task puppet order receive reward four stickers shared puppet child puppet either accidentally intentionally knocked tower cases adult observe intentionality outcome punished puppet giving stickers child hearing puppet protest children likely correct adult punishment share stickers puppet puppet actions accidental rather intentional results suggest rather passively accepting rewards punishments imposed authority figures young children spontaneously correct situations potentially believe unfair elsevier inc rights reserved
use narrative structures learning environments teaching computer programming acknowledgment storytelling importance classroom automatic generation narratives one research themes gems paper presents adaptive specification mechanism generates narratives considering characters emotional facet writing process specification included emotional state machine ornated adaptive methods methods help organize behavioral specification state machine end result takes form executable prototype demonstrates operation narratives generation mechanism
multi functional materials actuator applications developed toward reversibility sensitivity various actuating fields work magneto electro responsive materials consisting polyurethane matrix composites embedded magnetite nanoparticles mnp dispersed phase fabricated tailor electromechanical properties bending performance electric magnetic electromagnetic fields due superior characteristics mnp magnetic materials composites fabricated electronic polarization highly responsive electric field highest storage modulus sensitivity belonged mnp composite possessed value electric field moreover composites behaved electrostrictive material stress depended quadratically electric field demonstrated composites also possessed good recoverability fast response large bending angle relative pristine applied electric field interestingly steady state storage modulus response attained within first electrical actuation cycle composite fully reversible material addition shown superparamagnetism common characteristic fabricated composites magnetic field mnp composite provided largest bending distance magnetic field electromagnetic field respectively summary mnp composite material potential candidate used smart material influences electric magnetic fields existing dielectric materials elsevier rights reserved
novel proportional integral derivative based fuzzy neural network pid based fnn controller proposed study control speed vane type air motor vam servo system tracking periodic speed command first structure operating principles vam servo system introduced dynamics vam servo system analyzed derive second order state equation vam moreover due dynamic characteristics system parameters vam servo system highly nonlinear time varying pid based fnn controller integrates conventional proportional integral derivative neural network pidnn control fuzzy rules proposed achieve precise speed control vam servo system occurrences inherent nonlinearities external disturbances network structure line learning algorithm using delta adaptation law described detail meanwhile convergence analysis speed tracking error given using discrete type lyapunov function enhance control performance proposed intelligent control approach bit floating point digital signal processor dsp tmsf adopted implementation proposed control system finally experimental results illustrated show validity advantages proposed pid based fnn controller vam servo system
recent studies psychiatry reveal acceptance trauma media traditionally restricted immediate experience post traumatic stress disorder ptsd expanding include mediated experience development come mediated trauma manifest consequences essay addresses questions three cases trauma film paradigm early research program employed films simulate traumatic effects psychiatric study clinical effects watching catastrophic events television culminating september attacks reports drone operators exhibit ptsd symptoms flying combat missions away war zone recognition mediated trauma marks qualitative change understanding media effects rendering impact literal consequences clinical informs recent speculations possibility trauma media conceptual link visual media contemporary conceptions trauma
automated compliance checking acc building designs requires automated extraction information building information models bims however current industry foundation classes ifc based bims provide limited support acc lack necessary information needed perform compliance checking paper authors propose new method extending ifc schema incorporate related information objective semiautomated manner method utilizes semantic natural language processing techniques machine learning techniques extract concepts documents related building codes match extracted concepts concepts ifc class hierarchy proposed method includes set methods algorithms combined one computational platform method concept extraction utilizes pattern matching based rules extract regulatory concepts related regulatory documents method concept matching semantic similarity assessment select related ifc concepts extracted regulatory concepts machine learning classification method predicting relationship extracted regulatory concepts related ifc concepts proposed method enables extension ifc schema objective way using construction regulatory document test evaluate proposed method two chapters randomly selected international building code ibc chapter ibc used training development chapter ibc used testing evaluation comparing manually developed gold standards measure adoption rate precision achieved regulatory concept extraction ifc concept selection relationship classification respectively american society civil engineers
article examines face recognition key instance emergence smart photography smart photography drawing artificial intelligence ambient intelligence ami manifests habit mind karen barad way thinking humanist far predicated human machine autonomy representationalist quest unmediated objects faces among objects smart photography seeks autonomously represent examining two principal algorithms face recognition technology article show ways seeing allied ways thinking also ultimately discriminatory essentialist materialise software finally smart smart photography means learning discriminate classes faces fixed essentialised ultimately elusive stereotypical face terror gendered racialised could smart made smarter question politics rather progress
study investigates transition parenthood coparenting couples whose children entered nursery school right end maternity leave descriptive exploratory study carried qualitative data analysis method content analysis four double working couples parents aged years old answered sociodemographic data questionnaire semi structured interview coparenting results indicate transition parenthood fathers preserve better personal spaces mothers feel overwhelmed assume demands involving period hand coparenting performed equally since double work consequently early school insertion children impose dynamic contrast household chores shared equally associated gender roles results allowed approach reality couples pointed evidence changes performance coparenting
background several ingredients personal care products pcps classified endocrine disruptors eds concern raised whether use pcps affect human health aimed characterize norwegian female users skin care products compare life style characteristics heavy users non users methods cross sectional study consisted women age years participating norwegian women cancer study large population based prospective cohort study based self reported questionnaire data classified study subjects five groups according calculated percentage skin area creamed per day life style characteristics compared heavy users using body lotion twice day non users change use assessed repeated measurements results heavy users skin care products significantly lower bmi higher level physical activity higher income higher alcohol consumption fewer children shorter total time breastfeeding non users significantly fewer current smokers former smokers among heavy users among non users current earlier use oral contraceptives hormone replacement therapy hormonal intra uterine device significantly common among heavy users among non users use skin care products moderate extent weighted kappa consistent time many women classified user group category conclusions heavy users skin care products differ significantly non users bmi degree daily physical activity income number children use hormonal pharmaceuticals smoking alcohol consumption use skin care products common among women aged years norway use consistent time
study technology solve energy demand problem global warming replacing gasoline vehicles electric vehicles interesting solution electric vehicle uses electric motor drive powertrain research study evaluation centers main factors influence energy consumption non fixed route diesel fuelled buses fuel bus electric buses using artificial neuro fuzzy inference systems anfis method comparing energy consumption saving fuel bus model model metrology indicate significance factors affected energy consumption based collected questionnaires surveyed non fixed route buses around bangkok simulation fuel electric bus created artificial neuro fuzzy inference systems anfis method output method relates significance factors energy consumption units result study shows electric bus save around energy consumption compared fuel bus scenarios included study non fixed route buses years old changed electric buses defined percent replacement including percent results showed replacement save energy rate year however traffic conditions still affect energy consumption air conditioning electric bus consumes around total usage
current future space missions demand highly reliable board computing systems capable carrying high performance data processing present single computing scheme satisfies highly reliable operation requirement high performance computing requirement aim paper review existing systems offer new approach addressing problem first part paper detailed survey fault tolerant distributed computing systems space applications presented fault types assessment criteria fault tolerant systems introduced redundancy schemes distributed systems analyzed review state art fault tolerant distributed systems presented limitations current approaches discussed second part paper new fault tolerant distributed computing platform wireless links among computing nodes proposed novel algorithms enabling important aspects architecture time slot priority adaptive fault tolerant channel access fault tolerant distributed computing using task migration introduced cospar published elsevier ltd rights reserved
traumatic brain injury tbi contributes increased rates suicide post traumatic stress disorder military personnel veterans also associated risk neurodegenerative psychiatric disorders cross phenotype high resolution polygenic risk score prs analysis persistent post concussive symptoms pcs conducted army soldiers sustained tbi deployment used prospective longitudinal survey three brigade combat teams assess deployment acquired tbi persistent physical cognitive emotional pcs prs derived summary statistics large genome wide association studies alzheimer disease parkinson disease schizophrenia bipolar disorder major depressive disorder mdd years schooling college completion childhood intelligence infant head circumference ihc adult intracranial volume although study statistical power detect moderate large effect sizes association observed neurodegenerative psychiatric disorders suggesting persistent pcs share genetic components traits moderate large degree observed significant finding subjects high ihc prs recovered better cognitive emotional persistent pcs individuals enrichment analysis identified two significant gene ontology terms related result similar cell adhesion molecule binding similar neuromuscular process summary study indicated genetic predisposition persistent pcs tbi substantial overlap neurodegenerative psychiatric diseases mechanisms related early brain growth may involved
skyline operator determines points multidimensional dataset offer optimal trade state art cpu skyline algorithms exploit quad tree partitioning complex branching minimise number point point comparisons branch phobic gpu skyline algorithms rely compute throughput rather partitioning fail match performance sequential algorithms paper introduce new skyline algorithm skyalign designed gpu gpu friendly grid based tree structure upon algorithm relies search tree allows dramatically reduce amount work done gpu algorithm avoiding point point comparisons cost compute throughput trade allows skyalign achieve orders magnitude faster performance predecessors moreover numa oblivious port skyalign outperforms native multicore state art challenging workloads increasing margin cores sockets utilised
background aims regulatory cells tregs expand chronic hepatitis virus hcv infection inhibit antiviral immunity promote fibrosis direct acting antiviral agents daa revolutionized hcv therapy however unclear tregs normalized daa induced hcv elimination methods analyzed tregs baseline end therapy eot weeks svr svr long term weeks eot genotype infected patients successfully treated sofosbuvir sof plus interferon ifn ribavirin ifn free daa regimens sof plus daclatasvir simeprevir frequency phenotype suppressor function peripheral foxp cells studied multi color flow cytometry culture inhibition assays results frequencies activation status foxp cells remained elevated normal controls treatment groups even long term hcv elimination coculture assays indicated dose response relationship functional inhibition autologous effector cells confirmed activation tregs remained largely unchanged observation period unlike ifn free regimens sof plus ifn ribavirin induced transiently increased frequency foxp cells eot baseline eot foxp cells expressed activation markers glycoprotein repetitions predominant garp tumor necrosis factor receptor superfamily member showed unchanged vitro inhibitory activity conclusion although ifn based daa therapy induced transient expansion activated foxp cells neither ifn based ifn free daa regimens normalized frequencies activation status tregs one year viral elimination persistence immunosuppressive tregs may thus contribute complications liver disease even long term hcv cure lay summary chronic hepatitis virus hcv infection regulatory cells tregs reduce antiviral immune responses promote liver fibrosis may increase risk liver cancer gradually expand disease modern directacting antiviral agents daa cure hepatitis almost treated patients however study shows daa normalize increased frequency activation status tregs even long term hcv elimination tregs may persistently modulate functions immune system even cure hepatitis european association study liver published elsevier rights reserved
paper focuses effect changes couples employment status attitudes towards gender roles labour market paying special attention interaction partners status labour market shapes attitudes towards gender roles using data nine successive waves british household panel investigate change traditional couple male breadwinner woman homemaker types couple influences attitude towards gender roles labour market people living couple results point interaction change respondent status labour market partner one significantly influences attitudes towards gender roles labour market moreover change traditional breadwinner homemaker couple brings less support women employment finding holds true matter respondent gender
abnormalities cell mediated immune activation absence active somatic immune diseases consistently reported mood disorders apart important players regulation cells immune system cells essential normal brain development report studies relationship circulating levels helper cells structural functional brain imaging depressed bipolar patients since ccl ccr axis important entry brain differentiated various helper cell subpopulations basis chemokine receptor expression methods facs staining performed regulatory cells frozen leukocytes consecutively admitted inpatients affected major depressive episode without psychotic features course bipolar disorder healthy controls frequency helper populations associated dti fmri data acquired philips tesla scanner tract based spatial statistic used obtain measures white matter integrity fractional anisotropy axial radial mean diffusivity standard dti sequence directions patients also studied fmri moral valence decision task subjects decide whether morally tuned stimuli positive negative results percentage circulating ccr cxcr neg ccr ccr neg cells correlated positively higher fractional anisotropy fiber tracts contributing functional integrity brain patients healthy controls frequency circulating regulatory foxp cells correlated positively higher radial mean diffusivity patients frequency circulating regulatory cells also correlated lower neuronal responses negative versus positive morally tuned stimuli right dorsolateral prefrontal cortex patients thl cells correlated negatively white matter integrity several tracts healthy controls cells showed positive correlation levels pro inflammatory cytokines patients conclusion study shows new putative role cells cells playing role inducing autoimmunity auto inflammation might also play counter intuitive anabolic role maintenance functional structural integrity brain elsevier inc rights reserved
depressive disorders elderly persons frequent either first manifested younger age show recurrent pattern later life icd onset beyond years termed late onset depression lod lod higher tendency chronification implies increased risk progression especially vascular dementia multifactorial genesis depression old age includes psychosocial vascular metabolic factors requires multimodal therapy modules biological psychosocial level increasingly empirically proven depressive disorders executive cognitive deficits considered defined entity respect prognosis treatment first step treatment watchful waiting appropriate especially depressive adjustment disorders triggered acute psychosocial stressors loss relatives conflicts weeks pharmacological antidepressant therapy initiated least moderate depressive episode furthermore revised national guidelines depressive disorders also explicitly recommend psychotherapy alternative supplement pharmacotherapy elderly several forms psychotherapy emphasized cognitive behavioral therapy interpersonal therapy particular problem solving form treatment also carried professional groups thus alleviating treatment gap caused lack psychotherapists summary depressive disorder old age induce therapeutic nihilism stepped diagnostic assessments multimodal therapies individually adapted physical cognitive social resources patients
since yahtse glacier southern alaska advanced average rate similar year despite negative mass balance widespread thinning accumulation area low accumulation area ratio better understand interannual seasonal changes yahtse processes driving changes construct velocity ice surface elevation time series spanning years respectively using satellite optical synthetic aperture radar sar observations find contrasting seasonal dynamics steep slope icefall located approximately terminus icefall velocities peak may reach minima october synchronous development small embayment calving terminus glacier minimum speeds embayment plume turbid water emerges embayment consistent efficient channelized subglacial drainage system lowers basal water pressures leads focused submarine melt calving embayment however velocities near terminus fastest winter following terminus retreat possibly terminal moraine results decreased backstress terminus decelerated similar average rate similar day year transitioned tensile compressive longitudinal strain rates dynamically thickened rates year hypothesize response development advance terminal moraine described interannual changes decay significantly upstream icefall indicating icefall may inhibit upstream transmission stress perturbations suggest diminished stress transmission across icefall could allow moraine enabled terminus advance despite mass loss yahtse upper basin work highlights importance glacier geometry controlling tidewater glacier advance particularly climate favoring increasing equilibrium line altitudes
existing network security technology may intrusion need study intrusion tolerance technology basis existing model intrusion tolerance putted forward optimization finite automata state transition model intrusion tolerance system adding strategy updating status since conversion process states model meets semi markov theory therefore model used quantify theory gives calculation process steady probability state stabilizing probabilistic analysis state provide theoretical guidance basis network management personnel better maintain network security proven semi markov applied finite automata intrusion tolerant system feasible effective simple features
objective examine relation neuroticism fatigue chinese patients stroke design cross sectional study setting acute stroke unit participants survivors ischemic stroke recruited acute stroke unit may september interventions applicable main outcome measures personality trait neuroticism measured neuroticism subscale chinese version neo five factor inventory level fatigue measured fatigue assessment scale national institutes health stroke scale geriatric depression scale barthel index mini mental state examination administered obtain demographic clinical information results fatigue severity months stroke positively correlated geriatric depression scale neo five factor inventory neuroticism scores negatively correlated barthel index score conclusions neuroticism independent depressive symptoms predictor fatigue severity months stroke interventions psychological screening programs warranted early detection patients high risk poststroke depression american congress rehabilitation medicine
two dimensional localized correlated spectroscopy cosy offers greater spectral dispersion conventional one dimensional mrs techniques yet long acquisition times limited post processing support slowed clinical adoption improving acquisition efficiency developing versatile post processing techniques bolster clinical viability mrs purpose study implement non uniformly weighted sampling nuws scheme faster acquisition mrs nuws cosy sequence developed whole body mri phantom containing metabolites commonly observed brain physiological concentrations scanned ten times nuws scheme duration constant eight average sequence using channel head coil cosy spectra also acquired occipital lobe four healthy volunteers using proposed nuws conventional uniformly averaged cosy sequence nuws cosy sequence facilitated shorter acquisition time maintaining comparable snr humans phantom studies compared uniform averaging nuws schemes successfully demonstrated improved efficiency cosy facilitating reduction scan time without affecting signal quality elsevier inc rights reserved
demand textile products synthetic dyes increases growing global population textile dye wastewater becoming one significant water pollution contributors azo dyes represent dyes used worldwide hence significant contributor textile waste work removal reactive azo dye reactive orange water adsorption chitosan grafted poly poly ethylene glycol methyl ether methacrylate cts gma ppegma investigated chitosan cts first functionalized glycidyl methacrylate grafted poly poly ethylene glycol methyl ether methacrylate using nitroxide mediated polymerization grafting approach equilibrium adsorption experiments carried different initial dye concentrations successfully fitted langmuir freundlich adsorption isotherm models adsorption isotherms showed maximum adsorption capacities cts gma ppegma chitosan respectively langmuir equations estimated respectively fundamental assumptions underlying langmuir model may applicable azo dye adsorption could explain difference freundlich isotherm parameters determined cts gma ppegma chitosan respectively value one ten generally indicates favorable adsorption adsorption capacities chitosan ppegma physical mixture pure ppegma also investigated exhibited significantly lower adsorption capacities pure chitosan work cts gma ppegma proved effective parent chitosan increase adsorption capacity
background pacritinib highly selective kinase inhibitor specificity jak flt irak cfsr multicenter phase study evaluated maximum tolerated dose mtd safety clinical activity pacritinib patients myelofibrosis advanced myeloid malignancies methods phase dose escalation part study adults advanced myeloid malignancies received pacritinib daily phase part study adults refractory intermediate high risk newly diagnosed degree cytopenia received pacritinib primary endpoint reduction spleen volume week determined magnetic resonance imaging results five patients experienced dose limiting toxicity cycle phase clinical benefit rate patients achieving clinical improvement patients stable disease mtd established recommended phase dose phase primary endpoint achieved evaluable patients achieving spleen length reduction week measured physical examination week evaluable patients achieved decrease quality life symptom assessment total score gastrointestinal toxicities common adverse events predominantly grade severity grade anemia reported patients grade thrombocytopenia reported patients frequent aes considered treatment related diarrhea nausea vomiting fatigue grade treatment related aes reported seven patients four diarrhea grade treatment related aes reported leukopenia neutropenia lymphopenia reported conclusions pacritinib well tolerated demonstrated clinical activity study suggests pacritinib unique characteristics namely lack substantial myelosuppression manageable side effects making attractive target evaluation
aimthe burden chronic kidney disease ckd growing rapidly around world however limited information overall regional prevalence ckd well prognostic implications treatment patterns asian region established asian renal collaboration arc goal consolidating region wide data regarding ckd methodsthis collaborative project synthesize data perform meta analyses observational studies conducted asia studies identified systematic literature search including abstracts proceedings meetings electronic databases medline embase personal enquiry among collaborators experts region identify additional studies data sources registries cross sectional longitudinal studies describe prevalence ckd complications included longitudinal studies describe important clinical outcomes people ckd individual participant data sought possible studies included collaboration baseline parameters subsequent outcomes order maximize flexibility consistency data analyses conclusionsthis study initiative offering unique opportunity obtain information prevalence manifestations ckd asia well risk factors arc also provide insights important outcomes including progression ckd ckd complications cardiovascular disease death findings improve understanding kidney disease asia thus help inform service provision preventive care research across region
optimal stenting technique coronary artery bifurcations still debated additional advances computational simulations soon used compare stent designs strategies based verified structural hemodynamics results order identify optimal solution individual anatomy study patient specific simulations stent deployment performed cases replicate complete procedure conducted interventional cardiologists subsequent computational fluid dynamics cfd analyses conducted quantify hemodynamic quantities linked restenosis patient specific pre operative models coronary bifurcations reconstructed angiography optical coherence tomography oct plaque location composition estimated oct assigned models structural simulations performed abaqus artery geometries virtual stent expansion xience prime nobori stents created solidworks compared post operative geometry oct extracted used cfd simulations simvascular inflow boundary conditions based body surface area downstream vascular resistances capacitances applied branches mimic physiology artery geometries obtained virtual expansion good agreement reconstructed patient images quantitative comparison distance reconstructed post stent geometries revealed maximum difference area adverse indices wall shear stress pronounced thicker nobori stents patients findings verify structural analyses stent expansion introduce workflow combine software packages solid fluid mechanics analysis underscore important stent design features prior idealized studies proposed approach may ultimately useful determining optimal choice stent position patient elsevier ltd rights reserved
objective influence oestrogen testosterone replacement stroke risk examined well mechanisms oestrogen may protect post stroke damage however whether testosterone levels early time period haemorrhagic stroke influence long term mortality previously investigated examined whether concentrations predictive risk death setting university hospital design prospective study main measures testosterone oestrogen levels week haemorrhagic stroke measured predictive value levels clinical parameters size location severity stroke mortality three year length study assessed results glasgow coma scale low testosterone oestradiol ratio post stroke day independent predictors mortality stroke location hematoma volume predictive power conclusion testosterone oestradiol ratio day haemorrhagic stroke independent predictor mortality later months
paper provides critical review building neighborhood properties influencing energy airflows urban neighborhoods specifically review focus multi scale modeling required quantify influence building neighborhood properties energy consumption buildings energy consumption patterns buildings located dense city centers highly dependent surrounding urban neighborhood compared low density suburban rural regions building energy consumption patterns similar isolated building energy consumption patterns due complex nature outdoor airflow around buildings urban neighborhoods practical modeling approach utilizes multi scale modeling account different spatial temporal scales relevant transport processes specifically modeling approach aims identify important neighborhood properties influencing building energy consumption urban morphology parameters urban plan area density frontal area density mean height buildings represent successful examples emerging properties suitable development generalized solutions physical models neighborhood scale paper also reviews different modeling approaches account impacts urban neighborhood properties thermo fluid property air surfaces sky built environment required inputs accurate assessment building energy consumption furthermore emerging properties urban neighborhoods directly affect mitigation strategies better adaptation design performance metrics neighborhoods green building rating systems socio environmental factors elsevier ltd rights reserved
article provides ecological framework understanding adolescent initiated parent abuse review research adolescent initiated parent abuse identifying sociodemographic characteristics perpetrators victims gender age race ethnicity socioeconomic status ses bronfenbrenner ecological systems theory applied examines risk protective factors adolescent initiated parent abuse within micro maltreatment domestic violence parenting behavior disciplinary strategies meso peer influence exo media influence macro gender role socialization chronosystem change family structure levels findings review suggest older white children significantly likely abuse parents females selective target aggression males target family members general mothers significantly likely abused fathers however researchers also report variations association ses parent abuse domestic violence child maltreatment risk factors findings parenting behavior disciplinary strategies mixed peer influence exposure media violence gender role socialization change family structure potentially increase risk parent abuse practice research implications also discussed ecological systems framework allows examination various contexts interact influence parent abuse behavior provide needed directions research
commonly used analgesic anti inflammatory effects non steroidal anti inflammatory drugs nsaids among frequently used medications world spite prevalence reports nsaid misuse nsaid use disorder uncommon case report describes research participant met criteria dsm moderate substance use disorder based use prescribed ibuprofen assessed validated mini international neuropsychiatric interview mini case demonstrates dsm criteria within mini applied diagnose nsaid use disorder addiction researchers clinicians consider medications generally thought addictive like nsaids evaluating patients substance use disorder elsevier ltd rights reserved
work presents design fabrication characterization passive printed radiofrequency identification tag ultra high frequency band multiple optical sensing capabilities tag includes five photodiodes cover wide spectral range near infrared visible ultraviolet spectral regions tag antenna circuit connections screen printed flexible polymeric substrate ultra low power microcontroller based switch included measure five magnitudes issuing optical sensors providing spectral fingerprint incident electromagnetic radiation ultraviolet infrared without requiring energy battery normalization procedure designed applying illuminants entire system tested measuring cards colour chart sensing fruit ripening
introduction neurodegenerative parkinsonian syndromes significant clinical pathological overlap making early diagnosis difficult cerebrospinal fluid csf biomarkers may aid differentiation disorders synuclein neurofilament light chain protein limited diagnostic power specific protein biomarkers remain elusive objectives study disease mechanisms identify possible csf diagnostic biomarkers discovery proteomics discriminate parkinsonian syndromes healthy controls methods csf collected consecutively participants parkinson disease atypical parkinsonian syndromes including progressive supranuclear palsy multiple system atrophy corticobasal syndrome elderly healthy controls participants divided discovery validation set analysis samples subjected tryptic digestion followed liquid chromatography mass spectrometry analysis identification relative quantification isobaric labelling candidate protein biomarkers identified based relative abundances identified tryptic peptides predictive performance evaluated analysis validation set results tryptic peptides derived proteins found differ significantly atypical parkinsonism patients controls included acute phase inflammatory markers neuronal synaptic markers respectively increased decreased atypical parkinsonism levels subjects intermediate controls atypical parkinsonism conclusion using unbiased proteomic approach proteins identified able differentiate atypical parkinsonian syndrome patients healthy controls study indicates markers may reflect neuronal function plasticity amyloid precursor protein inflammatory markers may hold future promise candidate biomarkers parkinsonism published elsevier ltd
background study designed explore beneficial effects environmental enrichment white matter glial changes mouse model chronic cerebral hypoperfusion induced bilateral common carotid artery stenosis bcas methods total wild type male cbl mice underwent bcas sham surgery one week surgery mice randomly assigned three different groups varied amounts standard housing conditions std limited exposure day full time exposure full weeks weeks bcas surgery behavioural cognitive function assessed prior euthanasia brain tissues analysed degree gliosis including morphological changes astrocytes microglia results chronic cerebral hypoperfusion bcas increased clasmatodendrocytes damaged astrocytes disruption aquaporin immunoreactivity increased degree microglial activation proliferation bcas also impaired behavioural cognitive function changes significantly attenuated limited exposure compared full time exposure conclusions results suggest moderate limited exposure substantially reduced glial damage activation findings also suggest moderate rather continuous exposure beneficial patients subcortical ischaemic vascular dementia characterised white matter disease related inflammation
female dominated occupations tend lower paying also less time consuming flexible male dominated occupations women may pursue occupations short flexible workweeks expect primary caretakers future children pie registered study investigated subtle reminders child raising intentions shape college students occupational interests hypothesized priming women child raising intentions reminds future caregiving responsibilities decreases interest high hour low flexibility occupations however women reported less interest men careers regardless prime intentions raise kids versus pets reminding men child raising intentions decreased interest family unfriendly occupations particularly among men low hostile sexism results suggest whereas women may link child raising intentions occupational pursuits regardless whether intentions made salient reminders child raising intentions raise awareness nonsexist men future family responsibilities elsevier inc rights reserved
renewable energy sources gaining interest nonpolluting sustainable recently notable number renewable distributed generations dgs intermittent generation patterns interconnected distribution network meet growing load demand nullify environmental threats appropriate integration renewable dgs distribution networks crucial guarantee qualitative network operational benefits paper simple efficient approach proposed optimal placement sizing solar wind dgs distribution territory considering electrical network power loss minimization voltage stability network security improvement stochastic nature solar irradiance wind speed accounted using suitable probabilistic models weighted aggregation particle swarm optimization technique employed optimize objective functions considering bus voltage limit line loading capacity discrete size limit penetration constraints dgs strategic weight selection technique adopted assess well trade solution persuasion multiple objectives regarding performance distribution network proposed method applied typical indian rural distribution network satisfactory results obtained elsevier ltd rights reserved
carrier transport gaas based vertical cavity surface emitting lasers vcsels investigated means house multiphysics code particular emphasis description many valley effects conduction band algaas barriers effects revealed significant impact overall vcsel performance accounted effective density states obtained closed form model description included simplified simulation framework distributed bragg reflector pairs replaced equivalent homogeneous layer leads major reduction computational cost especially important view computer aided design devices
mechanism energy dissipation mechanical systems often nonlinear even though may forms nonlinearity dynamics nonlinear damping dominant source nonlinearity number practical systems analysis systems simplified fact show jump bifurcation behaviour indeed often well represented equivalent linear system whose damping parameters depend form amplitude excitation quasi linear model diverse sources nonlinear damping first reviewed paper example systems analysed initially sinusoidal random excitation simplicity assumed system stable nonlinear damping force depends nth power velocity sinusoidal excitation shown response often also almost sinusoidal methods calculating amplitude described based harmonic balance method closely related describing function method used control engineering random excitation several methods analysis shown equivalent general iterative methods need used calculate equivalent linear damper since value depends system response depends value equivalent linear damper power dissipation equivalent linear damper sinusoidal random cases matches dissipated nonlinear damper providing firm theoretical basis modelling approach clear physical insight finally practical examples nonlinear damping discussed microspeakers vibration isolation energy harvesting mechanical response cochlea
novel integrated oxy fuel transcritical rankine cycles capturing introduced analyzed carbon dioxide used working fluid extracted process high pressure liquid state process benefits high temperature solar cycle heat source lng cold energy heat sink solar energy used oxy fuel transcritical cycle evaporator heat source context required heat duty lng vaporization desired operating condition provided solar energy condensed employing cold energy lng increases net electrical power parametric analysis conducted turbine inlet temperature tit lng flow rate solar cycle operating parameters energy exergy analysis done find better performance process obtained results indicate tit lng flow rate positive effects exergy efficiency net electrical power generation also applying tit degrees concentrated parabolic collector area cpc equal lng absorbed high temperature solar energy net electrical power generated energy exergy efficiencies overall process respectively elsevier ltd rights reserved
era globalization organizations increasingly expanding overseas search new markets greater profitability colonizing new markets also means mastering inter cultural communication important tool strategic communication used global businesses today advertising since strategies advertisements increasingly developed internationally become imperative understanding country cultural characteristics like language lifestyle norms education attitudes etc context map different national value structures consequences behavior across cultural frontiers created professor geert hofstede study examines hofstede cultural dimensions affect individual units applicable dimensions micro level two ads skin care segment released part successful global campaign one india belonging hofstede family cluster one belonging contest cluster chosen analysis based popularity brand sub brand
recently relationship carbon dioxide emission aggregate energy consumption economic growth gdp widely studied many researchers using different approaches results conflicting controversy may due efficiency applied statistical approaches using different dataset main objective experimental study examine relationship gdp using different data transformation forms natural logarithm versus inverse form reducing heteroscedasticity panel data panel data consist countries two different economic levels countries developed versus developing countries data spanning panel data approach applied estimations based three models first estimations conducted constructing three different models first model estimated using original data without transformation second third model use natural logarithm log inverse form transform data two transformation forms applied reduce heteroscedasticity problem main findings show strong relationship three variables model inverse function transformation superior two models using original data log transformation highest illustrates emission explained gdp since gdp influential emissions higher lower gdp may lead environmental problems air water pollution therefore prevention action taken minimize environmental degradation
background recently pruritus recognised important association neuromyelitis optica spectrum disorders nmosd objective determine clinical radiological characteristics patients nmosd pruritus methods results among consecutive patients nmosd women reported pruritus aquaporin aqp antibodies mean age years age onset years duration illness years pruritus preceded neurological disturbances patients predominant patients experienced pruritus cervical dermatome followed cervicothoracic region trigeminal nerve lumbar region lesions extending cervicomedullary junction thoracic segment common site affection followed cervicothoracic cervicomedullary junction cervical cord cervical cord thoracic segment conclusion report one largest series reporting close association pruritus onset neurological symptoms nmosd highlights importance recognising rare symptom may help making correct diagnosis patient suspected demyelinating disorder patient nmosd early treatment immunomodulation pruritus may prevent minimise occurrence neurological dysfunction
die quenching process one hot forming processes making sturdy automobile parts process problems low productivity variation temperature dies strength materials problems disordered extending upgrading die quenching process solution problem figured characteristics die quenching process experiments water cooling dies made stainless steel installed chamber high precision compress testing machine experiment temperature dies workpiece measured martensitic transformation time workpiece maximum temperature die obtained data evaluation quenching experiment hardness microstructure high strength steel obtained observation quenched workpiece results new valuation method effect die quenching parameters proposed relationship among forming time cooling rate workpiece temperature dies verified investigation
research attitudes towards racial equality identified apparent paradox sometimes described principle implementation gap white americans accept equality ideal yet reject interventions designed achieve ideal article provide critical review empirical theoretical work field outline directions future research drawing program research conducted post apartheid south africa argue value widening field beyond traditional focus white policy attitudes united states developing relational models encompass fully perspectives historically disadvantaged well historically advantaged communities making greater use methods elucidate ordinary people construct meaning principle implementation gap informs indeed justifies normalizes associated patterns behavior prioritizing difficult question promote social change societies citizens embrace equality noble end often reject means might accomplished regards latterand given ascendancy prejudice based explanations principle implementation gapthe article evaluates particular strengths limitations prejudice reduction model social change
occurrence repetitive behaviours often harmful attributed traits traditionally described impulsive compulsive substance dependence excessive gambling hoarding behaviours common often occur general population psychiatric populations lack measures concurrently index range behaviours led development impulsive compulsive behaviours icb checklist study aims validate icb checklist general community sample factor analyses revealed two factor structure demonstrating good model fit two independent samples labelled impulsive compulsions compulsive impulsions comprising classically compulsive impulsive behaviours respectively reliability construct validity confirmed using correlations existing measures impulsivity compulsivity results suggest icb checklist valid practical assessment used monitor behavioural clusters characterised deficits inhibition elsevier ltd rights reserved
large scale aggregation analysis user opinions becoming increasingly relevant variety applications detecting social mood political topics tracking sentiment changes related events analysis diverse sentiments another important application becomes possible based ability modern methods capture sentiment polarity various topics high precision ever growing scale therefore need scalable way sentiment aggregation respect time dimension stores enough information preserve diversity allows statistically accurate analysis sentiment trends opinion shifts paper focusing novel problem aggregating diverse sentiments large scale based data sources continuously updated first develop theoretical framework models sentiment diversity contradiction defines two types contradictions depending distribution sentiments time second introduce novel measures capture sentiment diversity aggregated sentiment statistics third develop robust scalable indexing storage methods diverse sentiments finally propose adaptive approach identifying contradictions different time scales experimental evaluation demonstrates effectiveness proposed method capturing contradictions superiority relational databases real world scenarios
janus kinase jak plays essential role signaling hormone like cytokines growth factors convinced important target myeloproliferative neoplasms mpns therapy study series novel pyrrolo pyrimidine phenylamide hybrids designed synthesized potential jak inhibitors hybridization strategy vitro biological studies showed compounds exhibited potent activity jak especially compound identified suitable lead compound showed favorable pharmacokinetic profiles rats excellent vitro efficacy erythroleukemic cells high selectivity jak fold selectivity jak elsevier ltd rights reserved
background purpose examined association hydroxychloroquine hcq plasma lipid glucose levels rheumatoid arthritis cohort methods retrospective cohort analysis patients comparing fasting lipid profiles plasma glucose patients taking hcq divided patients groups based hcq exposure follow never taken hcq took intermittently took continuously used multivariable models propensity scoring compensate effect nonrandom treatment assignment results followed patients total observations adjusting age sex ethnicity disease modifying antirheumatic drugs dmards lipid lowering medications body mass index bmi smoking patients taking hcq baseline significantly lower total cholesterol low density lipoprotein ldl triglycerides lipid profile ratios high density lipoprotein hdl ldl hdl well higher hdl longitudinal analyses adjusting confounders patients continuously took hcq showed significantly lower ldl hdl ldl hdl higher hdl fasting plasma glucose levels significantly associated hcq exposure conclusions hydroxychloroquine use associated lower lipid levels plasma glucose cohort findings support need randomized trial establish role hcq cardiovascular disease prevention patients
proliferation differentiation controlled chromatin remodelling therefore enormous biological significance clinical value understanding specific signalling pathways affected histone replacement nucleosome work mass spectrometry used screen mammary epithelial cells changes histone levels throughout cell differentiation canonical histone isoform histone type histhac found undifferentiated proliferating cells histhac mrna induced egf specifically cdhi dchi cell sub population histhac mrna increased mek activation eph mammary epithelial cells breast cancer cells histhac silencing inhibited egf induced zeb expression cadherin regulation effect reverted histhac expression notably silencing histhac increased egfr erbb erk activation allow egf induced proliferation histhac expressed breast cancer molecular subtypes found altered breast cancers cases related histhac gene amplification mrna upregulation summary first study identifies canonical histone isoform histhac downstream egfr pathway regulating oncogenic signalling thereby contributing deregulation target genes elsevier rights reserved
background purpose determine women postpartum concerns changed time methods mothers postpartum concerns compared two clinical trials high risk pregnancy first time mothers advanced practice nurses apns provided care weeks postpartum recorded interactions clinical logs content analysis logs used identifying concerns results ninety five percent mothers african american mothers hispanic number infant concerns similar four top five infant concerns infant feeding top concern groups mothers concerned body changes birth control breastfeeding maternal health problems concerns health mothers concerned help fatigue finding things hard groups postpartum pain concerns problems accessing mother infant governmental programs conclusions mothers concerns regarding infant care essentially two time periods infant feeding top concern maternal concerns common postpartum pain needing help accessing government programs women high risk pregnancies health concerns implications practice results provide guidance helping minority mothers postpartum period
due thermal nature multi effect desalination med integration suitable power cycle highly desirable waste heat recovery one proper power cycle proposed integration internal combustion engine ice exhaust gas heat ice used produce motive steam required heat first effect med system also water jacket heat utilized heat exchanger preheat seawater paper studies thermodynamic model tri generation system composed ice integrated med ice thermodynamic model used place different empirical efficiency relations estimate performance load curves reasonably entire system performance coded matlab results proposed thermodynamic model engine verified manufacturer catalogue increasing engine load water production med unit increase cubic meters per day cubic meters per day tri generation efficiency economic analyses med unit integrated ice performed based annualized cost system method integration makes system economical determined higher market prices fresh water per cubic meter increase effects number significant period return decrement elsevier ltd rights reserved
increasing interest possible harmful effects prenatal exposure magnetic fields investigate effect weak intensity magnetic fields prenatal brain pregnant wistar rats continuously exposed one four intensities reference low medium high complex magnetic field sequence designed interfere brain development adults rats exposed low intensity complex magnetic field displayed impairments contextual fear learning showed anomalies cytological morphological development hippocampus particular low intensity exposures resulted reduction overall hippocampal size promoted subtle dysgenesis regions contrast exposure weaker stronger intensities complex magnetic field pattern interfere hippocampal development fear behavior findings suggest prenatal exposure complex magnetic fields narrow intensity window development result subtle permanent alterations hippocampal microstructure function lasting effects behavior isdn published elsevier ltd rights reserved
cities developed countries increasingly adopted rainwater tanks alternative water source last years rapid uptake rainwater tanks driven need reduce demand centralised water services pressure adapt population growth climate change impacts rainwater tanks part integrated urban water management approach considers whole water cycle provide water services fit purpose basis minimises impact local environment receiving waters rainwater tanks typically applied household scale non potable water source uses toilet flushing garden irrigation however paper reports communal approach rainwater harvesting water treated potable use communal approach rainwater harvesting offer benefits economies scale capital costs reduced land footprint centralised disinfection flexibility matching supply demand different households analysis showed communal approach could provide reliable potable water source small urban development however energy penalty associated water source compared centralised systems could addressed appropriate pump sizing outputs monitoring modelling study demonstrated rainwater harvesting expanded beyond current mainstream practices household systems non potable use certain development contexts analysis contained paper used improved planning design communal approaches rainwater harvesting
last decade several candidate genes maoa drd drd dat httlpr comt extensively studied potential moderators detrimental effects postnatal family adversity child externalizing behaviors aggression conduct disorder many studies candidate gene environment interactions published first part paper offers systematic review integration findings overview shows set heterogeneous findings however large differences studies terms sample composition conceptualizations power difficult determine different findings indeed illustrate inconsistent findings findings simply incomparable second part paper therefore argue one way help resolve problem development theory driven priori hypotheses biopsychosocial mechanisms might underlie theoretically based approach help specify research strategies create comparable findings help interpret different findings studies accordance describe three possible explanatory mechanisms based extant literature concepts emotional reactivity reward sensitivity punishment sensitivity mechanism discuss link putative mechanism externalizing behaviors genetic polymorphism family adversity possible research strategies test mechanisms implications interventions discussed
present study examined relations prosocial tendencies dispositional sympathy prosocial behavior psychological adjustment using multi method multi informant approach socioeconomically diverse sample first second generation chinese american children immigrant families age years tested concurrent associations children dispositional sympathy rated parents teachers children observed prosocial behavior psychological adjustment parent teacher reported externalizing problems social competence cultural socio demographic factors children chinese american orientations family socioeconomic status ses child status children age sex social desirability results correlations structural equation modeling suggested different measures prosocial tendencies related differently children psychological adjustment parent teacher rated sympathy associated higher child social competence lower externalizing problems within across reporter contrast child rated sympathy associated higher teacher rated social competence observed prize donation associated lower teacher rated externalizing problems different measures prosocial tendencies also showed different relations cultural socio demographic factors findings suggest prosocial tendencies unitary construct chinese american immigrant children manifestations prosocial tendencies adjustment implications might depend context targets tendencies
methicillin susceptible staphylococcus aureus mssa bacteremia associated high morbidity mortality traditionally antistaphylococcal penicillins asps considered agents choice treatment mssa bacteremia vancomycin demonstrated poorer outcomes several studies recommended patients severe penicillin allergies although cefazolin considered alternative asps patients nonsevere penicillin allergies cefazolin offers several pharmacologic advantages asps convenient dosing regimens antimicrobial stewardship programs increasingly using cefazolin preferential agent mssa infections part cost saving initiatives concerns susceptibility hydrolysis type beta lactamases particularly high inocula seen deep seated infections endocarditis selective pressures unnecessary gram negative coverage lack comparative clinical data precluded recommending cefazolin first line therapy mssa bacteremia recent clinical studies however suggested similar clinical efficacy better tolerability lower rates discontinuation due adverse drug reactions cefazolin compared asps variables adequate source control intravascular catheter removal debridement drainage enhanced pharmacodynamics aggressive cefazolin dosing may mitigate role cefazolin inoculum effect factor determining improved clinical outcomes review highlight utility cefazolin versus asps treatment mssa bacteremia focus clinical efficacy safety
water chemistry economics commercial scale inland marine integrated multi trophic aquaculture imta system investigated system used combination constructed wetland sand filter followed constructed wetland geotextile bags treat solids waste study demonstration zero discharge system commercial nursery production wetland plants combined marine ras treat saline solid waste total suspended solids tss chemical oxygen demand cod total nitrogen total phosphorus concentrations measured plant soil samples analyzed significant difference effluent concentrations found variability inherent commercial scale system made difficult isolate individual efficiencies three treatment systems production wetland plants critical aiding nutrient removal facilitating aggregation solids providing conditions denitrification average nitrate concentration decreased time due denitrification occurring plant beds water samples analyzed dissolved metals showed gradual increase concentration time imta system successfully produced florida pompano fish waste uneaten feed provided enough nutrients produce multiple cohorts wetland plants two year period economic analysis indicated one year production system would produce profit production florida pompano alone would result positive net return sales wetland plants necessary system break even ultimately produce profit production facility sarasota elsevier rights reserved
disability child affects child also presents socioeconomic psychological impacts child family study aims describe service needs caregivers children disabilities state penang malaysia determine child family characteristics predisposing caregiver needs cross sectional survey conducted february june among caregivers children aged years disabilities registered penang department social welfare caregivers completed self administered mailed questionnaire containing item caregiver needs scale cns item cns rated point likert scale ranging help needed help extremely needed total surveys available analysis response rate cns contained four domains help getting information services child domain highest mean score followed help finances help coping child help getting childcare domain lowest mean score multivariate regression analysis identified caregivers younger children severe disability caregiver needs domains besides caregivers children learning disability needed help getting information help coping caregivers children learning multiple disabilities needed help getting childcare compared children disability caregivers indian ethnicity less tertiary education medical problems needed help finances findings caregiver needs study help inform planning family support services children disabilities penang malaysia
article proposes parallel kinematic solar tracker designed driving high concentration photovoltaic modules kind module produces energy oriented misalignment errors lower degrees generally parallel kinematic structure provides high stiffness precision positioning features make mechanism fit purpose article describes work carried design suitable parallel machine already existing architecture chosen geometrical parameters system defined order obtain workspace consistent requirements sun tracking besides analysis singularities system carried method used singularity analysis revealed existence singularities previously identified kind mechanism analysis mechanism developed low nominal energy consumption elevated stiffness found small scale prototype system constructed first time control algorithm also developed implemented tested finally experimental tests carried order verify capability system ensuring precise pointing tests considered passed system showed orientation error lower degrees sun tracking
recent approaches vitro experimental study cardiac fluid mechanics involve use whole biological structures investigate lab novel therapeutic approaches treatment heart pathologies enhance reliability repeatability influence actuation strategy experimental apparatuses biomechanics biological structures needs assessed using echography intracardiac high speed imaging compared mitral valve anatomo functional features coaptation areas lengths papillary muscles valvular plane distances two passive beating heart mock loops internal ipml external epml pressurization ventricular chamber apparatuses showed fluid dynamic conditions closely resembled physiology mvs analyzed epml presented coaptation areas lengths systematically higher exhibited greater variability early peak systole compared ipml moreover epml leaflets exhibited convexity high curvature toward atrium ipml coaptadon lengths ranged similar available clinical data papillary muscles valve plane distances stable throughout systole conclusion apparatuses allow reproducing vitro left heart hemodynamics terms flow rates pressures proper mitral valve continence results suggest ipml suitable replicating physiological functioning epml may potential model study pathologies ipem published elsevier ltd rights reserved
aim study surface functionalization new green ceramic material obtained using packaging glass waste pgw improve cleanability objective reached deposition air brushing nanostructured coating based titania silica sol gel suspension coatings deposited glazed unglazed ceramic substrates thermal treatment conditions temperature optimized obtained results suggest applied coatings transparent show good scratch resistance photocatalitic activity tested conditions photodegradation process mechanical properties clearly affected thermal treatment thus sample surface roughness best surface properties obtained thermal treatment temperature degrees coatings exhibit either cracks substrate developed surface modified ceramic material attractive potential sustainable building material elsevier ltd techna group rights reserved
fibrosis disease excessive amounts connective tissue accumulate response physical damage inflammatory insult affects nearly every tissue body progress state organ malfunction death hallmark fibrotic disease excessive accumulation extracellular matrix secreting activated myofibroblasts mfbs place functional parenchymal cells identification agents selectively inhibit trans differentiation process leading formation mfbs represents attractive approach treatment diverse fibrosis related diseases herein report development high throughput image based screen using primary hepatic stellate cells identified antifungal drug itraconazole ita inhibitor mfb cell fate resident fibroblasts derived multiple murine human tissues lung liver heart skin chemical optimization ita led molecule cbr devoid antifungal human cytochrome inhibitory activity excellent pharmacokinetics safety efficacy rodent models lung liver skin fibrosis findings may serve provide strategy safe effective treatment broad range fibrosis related diseases
based two component model episodic memory development across lifespan examined contribution memory monitoring binding processes older adults increased susceptibility false memories high subjective confidence younger older adults worked modified version continuous recognition task schnider von daniken gutbrod participants saw set unrelated word pairs three subsequent runs identify pairs repeated within runs age group differences veridical recognition repeated word pairs across three runs reliable false recognition lure pairs increased across runs older adults indicating increasing interference previous encounters word pairs age groups showed decrease false recognition rearranged pairs across runs decrease pronounced younger adults older adults confident younger adults falsely recognising lure rearranged word pairs indicating overall memory confidence calibration less accurate old age relative early adulthood taken together results suggest age related decline memory monitoring interaction binding deficits contribute age differences false memory highly familiar events
article extends complicates theory strict churches strong based strict demands followed followed brahma kumaris nepal successful strict religious groups must strict also frame strictness ways resonate everyday experiences commonly held beliefs members nepali women involved brahma kumaris tend accept follow group demands demands framed modern framing resonant prevailing definitions modernity offered western development agencies modern framing resonant case framing celibacy spiritual birth control strict demand followed frame rejected favor practice defined different terms
background brachial plexus important anatomical structure damaged perinatal postnatal periods result injury available literature provide much discussion development brachial plexus human fetuses objectives goal study mathematical analysis fetal brachial plexus growth geometry material methods study examined human brachial plexuses derived fetuses including females aged weeks fetal life crown rump length crl ranging anthropological methods preparation digital image acquisition image measurement tool scion image windows program statistical methods applied fetus somatic well linear parameters observed lengths diameters distances nerves making brachial plexus geometry results majority linear parameters analyzed sexual dimorphism asymmetry observed following asymmetries sexual dimorphisms appear significant clinical point view asymmetry length nerve left radix asymmetry diameters musculocutaneous nerve left median ulnar nerves right well increased distance nerves roots female fetuses weekly growth individual parts plexus varied correlation ratios among rapid growth observed weeks slowest weeks four formulae used mathematical growth model linear regression logarithmic function von bertalanffy growth model gompertz curve conclusions prenatal development brachial plexus constant applied mathematical functions proved useful describing growth rate adv clin exp med
background despite availability guidelines specific treatment hereditary angioedema hae attacks hae morbidity mortality rates remain substantial hae attacks major medical issue requiring specific treatment well considerable socio economic burden report protocol designed test whether dedicated call centre effective usual practice management patients experiencing hae attack methods design prospective cluster randomised single blind parallel group multicentre trial evaluates morbidity consequent socio economic costs management patients experiencing hae attack dedicated call centre compared usual practice trial aims recruit patients patients intervention arm provided sos hae card call centre freephone number access case attack centre mission provide recommended expert advice early home treatment centre route call local emergency medical service competency hae management even arrange drugs needed specific treatment hae attack sent emergency department local hospital primary outcome measure number hospital admissions hae attack patient followed every months years study approved ethics committee comite protection des personnes ile france registration number date approval january discussion sos hae protocol designed address handling attacks experienced patients hae home proposed trial determine whether setting dedicated call centre effective usual practice terms reducing morbidity given numbers hospital admissions results also anticipated important implications terms socio economic costs healthcare services patients
social cognitive skills indispensable successful communication others substantial research determined deficits abilities patients mental disorders neurobiological development continuing adulthood cross cultural differences social cognition demonstrated moreover symptomatic patterns mental disorders may vary according cultural background individual cross cultural studies thus help understanding underlying biological mechanisms factors influence behavior health disease addition studies apply novel paradigms assessing impact culture cognition may benefit advance neuroscience research review authors give overview cross cultural research field social cognition health mental disorders provide outlook future research directions taking neuroscience perspective
human activity recognition har important part ambient intelligence systems since provide user context information thus allowing greater personalization services one problems har systems labeling process training data costly hindered practical application common approach train general model aggregated data users problem new target user model perform poorly biased towards majority type users take account particular characteristics target user overcome limitation user dependent model trained data target user optimal particular user however requires considerable amount labeled data cumbersome obtain work propose method build personalized model given target user require large amounts labeled data method uses data already labeled community users complement scarce labeled data target user results showed personalized model outperformed general user dependent models labeled data scarce
objectives prevalence cardiovascular diseases increases age especially postmenopausal women study investigated dietary patterns associated body mass body fat japanese middle aged women study design cross sectional main outcome measures study used baseline data collected previous study women aged years participants assessed age menopausal status lifestyle factors body composition dietary habits using brief type self administered diet history questionnaire provides information amounts nearly nutritional factors consumed previous month classifying body mass index bmi low percentage body fat low sought identify nutritional factors associated bmi percentage body fat results consumption differences high low bmi high low body fat percentage groups significant nutritional factors except cryptoxanthin multiple logistic regression analysis adjusting age menopausal status working exercise smoking revealed higher cryptoxanthin intake associated low bmi adjusted odds ratio per day increase cryptoxanthin intake confidence interval low body fat percentage adjusted odds ratio per day increase cryptoxanthin intake confidence interval conclusions higher intake cryptoxanthin shown related low body mass body fat japanese middle aged women authors published elsevier ireland ltd
effects novel atp sensitive channel atp channel opener activity reconstituted katp channels investigated using cell attached recordings katp channels studied hek cells expression inwardly rectifying family channel subunits kir kir kir different types sulphonylurea receptors sur sur sura surb activated surb kir channels concentration dependent manner caused weak activation sur kir channels sura kir channels expressed hek cells reversibly suppressed diazoxide elicited sur kir channels activity pinacidil elicited sura kir channel activity however affect surb kir channels fully activated pinacidil little inhibitory effects activity kir delta channels truncated isoform kir mutant channels kir delta cca expressed hek cells also elicited activity surb kir channels expressed hek cells concentration dependent manner therefore relatively effective activator smooth muscle type katp channels surb kir surb kir partial antagonist pancreatic type katp channels sur kir cardiac type katp channels sura kir results suggest pharmacological agent possess either agonist antagonist actions activity katp channels depending subtype sur
introduction ample evidence suggested role sigma receptor affective disorders since interaction numerous antidepressants sigma receptors discovered recent study japanese subjects found genetic variant within encoding gene sigmar rsa associated major depressive disorder mdd aimed evaluate polymorphism mdd bipolar disorder well relationship response treatment antidepressants mood stabilizers methods total mdd patients treated acute episode depression patients treatment mood stabilizers manic mixed episode controls genotyped discharge response treatments evaluated mdd patients hamilton rating scale depression hrsd young mania rating score ymrs respectively results korean sample allele frequencies different reported asian non asian populations genotype associated trend mdd significant effect observed response antidepressants mdd mood stabilizers although genotype frequent among patients experiencing mixed episode conclusion present findings first propose putative role genetic variants within sigmar sigma receptor sigma receptor modulate number central neurotransmitter systems well signaling pathways neurotrophin growth factor signaling seemingly involved mood disorders
paper conduct research computer graphics rendering technology based gpu parallel computing system traditional geometry based polygon rendering technique due difficulty modeling rendering time long adapt large scale complex scene accurately modeling real time display hand improvement image acquisition equipment precision falling prices easy get high precision image information based image rendering technology gradually become one main means scene rendering basis circumstance propose new perspective methodology optimize traditional ways provide systematic modification
simplified one pot less harmful method introduced synthesis borinic acid monomer corresponding borinic acid polymer pba prepared reversible addition fragmentation chain transfer polymerization property investigations confirm characteristics pba new type smart material field thermo responsive polymer potential application pba field enzymatic biofuel cell illustrated wide open circuit potential
background preclinical studies reveal associations intestinal ganglioside content inflammatory bowel disease ibd since low level ganglioside associated higher production proinflammatory signals intestine important determine safety bioavailability dietary ganglioside application potential therapeutic agent materials methods healthy volunteers hvs completed week supplementation study demonstrate safety bioavailabity ganglioside consumption hvs randomized consume milk fat fraction containing ganglioside placebo patients ibd consumed ganglioside supplement small pilot study plasma gangliosides characterized using reverse phase liquid chromatography qqq mass spectrometry intestinal permeability assessed oral lactulose mannitol quality life assessed quality life ibd questionnaire results adverse events associated dietary ganglioside intake ganglioside consumption increased plasma content total weeks hvs consuming ganglioside exhibited decrease intestinal permeability consumption ganglioside associated increase emotional health improvement systemic symptoms patients ibd conclusion impaired intestinal integrity characteristic ibd results increased permeability bacterial antigens decreased nutrient absorption intestinal integrity may improved dietary treatment specific species ganglioside ganglioside safe bioavailable dietary compound consumed potentially improve quality life patients ibd treat disorders involving altered ganglioside metabolism
objectives incarceration rate united states increased rapidly since mid accordingly large number children exposed parental incarceration research finds parental incarceration associated deleterious physical mental health outcomes among children little known children health care access methods used data national survey children health population based nationally representative survey non institutionalized children ages united states estimate association exposure parental incarceration children unmet health care needs results logistic regression models adjust array demographic socioeconomic characteristics children exposed parental incarceration compared counterparts times odds unmet health care need analyses disaggregate type unmet health care need mental dental vision mental health suggest association driven greater likelihood unmet mental health care needs conclusions children exposed parental incarceration vulnerable group especially risk physical mental health problems face challenges health care access especially mental health care access given parental incarceration concentrated among children need health care parental incarceration may exacerbate existing inequalities unmet health care needs
based large displacement non linear elastic generalized variational principle coupling effect axial flexural action shearing strain energy torsional strain energy stiffening girder considered large displacement incomplete generalized potential energy functional space coupling free vibration three span self anchored cable stayed suspension bridge presented constraint variation fundamental differential equations vertical flexural vibration lateral flexural vibration longitudinal vibration torisional vibration formulated also presented equations main tower respect longitudinal lateral vibration linear free vibration differential equation obtained nonlinear items discarded approach provides theoretical basis analysis natural vibration character self anchored cable stayed suspension bridges
paper presents synthesis procedure using signal flow graph sfg technique realize general nth order allpole voltage transfer function employing voltage differencing buffered amplifiers vdbas grounded capacitors proposed methodology general contains vdbas grounded capacitors without needing external passive resistors also show design procedure given simple structure convenient tenability suitable integration furthermore circuit low sensitivity also provides high input low output impedances suitable voltage mode operation pspice simulation results agree well theoretical analysis also included
background although established drugs treatment cardiovascular diseases due adverse effects drugs may clinically applicable patients recent trends seen emergence drugs act funny current channels induce selective heart rate reduction ivabradine one drug developed coronary artery disease heart failure inconsistent evidence effect selective inhibitor reduction cardiovascular related mortality morbidity inconsistency warrants need meta analysis consider effectiveness efficacy ivabradine treatment coronary artery disease heart failure methods randomized controlled trials minimum follow period one year searched pub med medline embase cochrane central register controlled trials published eligible study assessed risk bias using cochrane risk bias assessment tool outcomes assessed study included cause mortality cardiovascular related mortality hospitalization new worsening heart failure adverse events subgroup analysis publication bias assessed used mantel haenszel method random effects analysis done using revman study registered prospero prospero crd result three trials total participants met meta analysis criteria pooled analysis showed ivabradine effective reducing cardiovascular deaths cause mortality coronary revascularization hospital admission worsening heart failure however drug found significantly increase adverse events phosphenes blurred vision symptomatic bradycardia atrial fibrillation subgroup analysis duration follow cardiovascular outcomes found difference effect ivabradine depending duration follow publication bias reporting included studies conclusion meta analysis suggests ivabradine effective reducing cardiovascular related morbidity mortality unless used specific conditions contrary use drug strongly associated onset untoward new adverse events finding strongly supports previous findings informs rational evidence informed clinical use ivabradine
eminent web applications today data intensive data generated order petabytes zetabytes using relational databases storing complicates storage retrieval degradation performance big data explosion demanded need flexible high performance storage concept nosql movement nosql databases designed overcome flaws relational databases including security aspects effective performance efficient storage criteria satisfied non relational databases attackers usual found way nosql databases considered secure injection attacks one top listed attack type relational databases poses threat non relational databases well mongodb one prominent nosql databases application development trends shifting paper present different injection attacks leading nosql database automata based detection prevention technique attack also evaluate effectiveness different subjects number legitimate well illegitimate inputs results show approach able detect attacks
literature presents many application programming interfaces apis frameworks provide state art algorithms techniques solving optimisation problems said apis frameworks focused problem data peculiarities details variant problem virtually impossible provide general tools broad enough useful large scale however benefits employing problem centred apis environment improving understanding problem providing fairness results comparison providing efficient data structures different solving techniques etc therefore work propose novel design methodology api focused optimisation problem methodology relies data parser handle problem specification files set efficient data structures handle information memory intuitive fashion researchers efficient solving algorithms also present concepts solution dispenser manage solutions objects memory better built garbage collectors finally describe positive results employing tailored api project involving development optimisation solutions workforce scheduling routing problems
introduction dedicated progestin emergency contraceptive pills ecps available prescription brazil since however utilization emergency contraception limited conducted mystery client study retail pharmacies three regions assess current availability methods using predetermined client profile approached random sample chain independent pharmacies urban areas southeastern northeastern central west regions documented product availability price client pharmacy representative interaction site analyzed data descriptive statistics content themes results visited pharmacies early three pharmacies ecps stock time interaction offered client medication without prescription general pharmacy representatives ask questions provide client information emergency contraception prompted one third pharmacy representatives inaccurately reported levonorgestrel ecps could used immediately within time intercourse conclusion despite current regulatory status findings suggest progestin ecps widely available without prescription additional efforts ensure women date medically accurate information progestin ecps appear warranted findings suggest work needs done align national regulatory policies international standards evidence based practices implications zika virus epidemic shined spotlight importance providing timely access emergency contraception latin america public health emergency offers window opportunity advance national policies practices ensure brazilian women access full range reproductive health services elsevier inc rights reserved
study sets extend current knowledge parenting stress fear hypoglycemia foh parents children type diabetes mellitus tdm examined relationship parental children foh metabolic control reflected hbac mediated parenting stress total parents children tdm recruited routine physician appointment parents completed questionnaires parenting stress foh children eight years older also completed questionnaire foh hbac values obtained children mediation analysis revealed indirect association parental foh hbac values parenting stress sobel indirect association children foh hbac concluded parental foh indirect association child metabolic control mediated parenting stress simply fear hypoglycemia predicts parent stress turn predicts metabolic control
background study assessed knowledge personal safety skills among children developmental disabilities parents perceptions children knowledge method exploratory study examined mental health records children developmental disabilities referred abuse risk reduction group community mental health setting qualitative analysis children responses questions personal safety skills knowledge related physical development personal safety appropriate inappropriate touch safety skills respond inappropriate touch indicated participants varied inconsistent levels knowledge results consistent literature results indicate risk factors sexual abuse among children developmental disabilities including children difficulty distinguishing appropriate inappropriate touch lack knowledge regarding appropriate venues disclosing inappropriate touch among parents lack certainty regarding children knowledge ability keep safe identified conclusion results support need education personal safety children developmental disabilities families
critical node discovery plays vital role assessing vulnerability computer network malicious attacks failures provides useful tool one greatly improve network security reliability paper propose new metric characterize criticality node arbitrary computer network refer combined banzhaf diversity index cbdi metric utilizes diversity index based variability node attributes relative neighbours banzhaf power index characterizes degree participation node forming shortest paths banzhaf power index inspired theory voting games game theory proposed metric evaluated using analysis simulations criticality nodes network assessed based degradation network performance achieved nodes removed use several performance metrics evaluate network performance including algebraic connectivity spectral metric characterizing connectivity robustness network extensive simulations number network topologies indicate proposed cbdi index chooses critical nodes removed degrade network performance greater extent critical nodes based criticality metrics removed elsevier ltd rights reserved
growing recognition involving patients development new patient reported outcome measures helps ensure outcomes matter people living health conditions captured describe discuss different experiences integrating patients full patient research partners prps outcomes research multiple perspectives researcher patient funder drawing three real world examples diverse experiences highlight strengths challenges impact partnering patients conceptualize design conduct research disseminate findings basis experiences suggest basic guidelines outcomes researchers establishing research partnerships patients including establishing supportive organizational institutional policies cultivating supportive attitudes researchers prps recognition partnerships evolve time grounded strong communication shared goals adhering principles respect trust reciprocity learning addressing training needs team members ensure communications prps conversant familiar language process research identifying resources advanced planning required successful patient engagement recognizing value partnerships across stages research three experiences presented explore different approaches partnering demonstrate fundamentally change way research work conceptualized conducted disseminated serve exemplars forms patient centered outcomes research work needed identify skills qualities approaches best support effective patient researcher partnerships
micrornas mirnas belong family small non coding rnas mediate gene expression post transcriptional regulation increasing evidence demonstrated mir enriched muscle tissues myogenic cells aberrant expression could induce occurrence development cardiac disorders cardiac hypertrophy heart failure etc review summarized regulatory roles mir cardiac disorders underlying mechanisms suggest mir may potential diagnostic therapeutic tool cardiac disorders
imaging genetics emerging field investigation neuro mechanisms linked genetic variation although imaging genetics recently shown great promise understanding biological mechanisms brain development psychiatric disorders studying link genetic variants neuroimaging phenotypes remains statistically challenging due high dimensionality genetic neuroimaging data becomes even challenging studying gene environment interaction gxe neuroimaging phenotypes study proposed set based mixed effect model gene environment interaction mixge neuroimaging phenotypes structural volumes tensor based morphometry tbm mixge incorporates fixed random effects gxe investigate homogeneous heterogeneous contributions multiple genetic variants interaction environmental risks phenotypes discuss construction score statistics terms associated fixed random effects gxe avoid direct parameter estimation mixge model would greatly increase computational cost also describe score statistics combined single significance value increase statistical power evaluated mixge using simulated real alzheimer disease neuroimaging initiative adni data showed statistical power superior burden variance component methods demonstrated use mixge exploring voxelwise effect gxe tbm made feasible computational efficiency mixge discovered potential interaction effect gene abca cardiovascular risk local volume change right superior parietal cortex warrants investigation
accurate algorithm three dimensional pose recognition rigid object presented algorithm based adaptive template matched filtering local search optimization scene image captured bank correlation filters constructed find best correspondence current view target scene target image synthesized means computer graphics synthetic image created using known model target iterative procedure based local search computer simulation results obtained proposed algorithm synthetic real life scenes presented discussed terms accuracy pose recognition presence noise cluttered background occlusion experimental results show proposal presents high accuracy pose estimation using monocular images society photo optical instrumentation engineers spie
paper presents low power rail rail amplifier paralleled folded cascold structure input stage feed forward class output stage switch bias circuit switching hoost driving capability input single low else amplifier works switching state save power simulations using smic process cooled cadence specre supply voltage amplifier performs almost gain cmrr reaches lowest static power consumption amplifier used pga hige precision sigma delta adc buffer meet input sigle range gain pga
purpose etiological treatment currently lacking langerhans cell histiocytosis lch receptor activator nuclear factor kappa ligand rankl appears play central role lesional immunological process inducing compensatory osteoprotegerin opg activation preliminary study aimed evaluate first time use denosumab rankl inhibitor targeted treatment strategy lch order support enhance endogenous opg action order control alter lesional immunological process procedures two adult female patients painful osteolytic bone lesions concomitant pulmonary involvement received bimonthly denosumab total doses results patients reported immediate pain relief within first two weeks following dose denosumab one month following last dose almost full remission initial osteolytic lung lesions observed although apparent new bone lesion detected one patient treated single intralesional steroid injection adverse events recorded throughout treatment period patients active disease months following last denosumab dose conclusions denosumab could considered effective treatment option adults multisystem lch also exerting significant analgesic effect bone lesions warranting investigation elsevier inc rights reserved
subjects mild cognitive impairment mci increased risk developing alzheimer disease functional brain networks presumably already altered test hypothesis compared magnetoencephalography meg eyes closed resting state recordings mci subjects healthy elderly subjects present exploratory study functional connectivity different frequency bands assessed phase lag index pli source space normalized weighted clustering coefficient normalized path length normalized well network measures derived minimum spanning tree mst betweenness centrality node degree calculated first found altered pli values lower upper alpha bands mci patients compared controls thereafter explored network differences frequency bands normalized differ groups whereas node degree mst differed although differences survive correction multiple testing using false discovery rate fdr exploratory study may conclude increases decreases observed pli values lower upper alpha bands mci patients may interpreted dual pattern disconnection aberrant functioning network measures line connectivity findings indicating lower efficiency brain networks mci patients mst centrality measures sensitive detect subtle differences functional brain networks mci traditional graph theoretical metrics
study establishes scientific reasonable feasible comprehensive evaluation system green building power supply system design implementation achieve optimization thermal environmental economic performance unlike traditional evaluation methods use single index economic performance exergy efficiency criterion proposed evaluation method takes annual revenue exergy efficiency emission system reliability indices advanced comprehensive evaluation method based combination method gray relational analysis gra analytic hierarchy process ahp assess multiobjective performance building power supply systems method applied compare four kinds power supply system hospital determine optimal system result shows system combines cooling heating power supply systems cchp adding solar photovoltaic panels best comprehensive performance capacitance solar panels large enough
although gastric tumors overlapping radiologic appearances unusual tumors may present specific imaging features using multidetector computed tomography mdct water negative oral contrast agent intravenous contrast medium provide critical information diagnosis gastric diseases addition mdct evaluate involvement gastric wall extragastric extent disease compared gastroenteroscopy double contrast upper gastrointestinal study regarding lesion location size enhancing growth patterns presence calcification fat involvement gastric wall adjacent structures may provide useful information review article review relevant literature discuss features histopathologic findings different types gastric lesions lesions divided benign glomus tumors schwannomas leiomyomas lipomas malignant gastrointestinal stromal tumors mucinous carcinomas lymphomas carcinoid tumors tumor like lesions ectopic pancreas bezoar familiarity imaging appearances pathologic findings help physicians make accurate diagnosis
smart textiles become dominant trend future textiles development especially wearable electronics however electronic garment designs often look technical textile reflected slow growth market therefore design approach proposed design conductive paths electric stimulation garments three steps modelling division conquer pattern refinement enhance aesthetics transcutaneous electrical nerve stimulation tens knitwear garment refined conductive network developed evaluated output waveforms spectrums resulting tens knitwear similar tens signals resistance variations smaller per cent optimization largely due truncation deformation method could provide feasible systematic approach design electric stimulation textiles using conductive fabrics meet requirements functionality aesthetics
paper presents new technique lower computational cost electrothermal analysis large chip power distribution network based node reduction strategy following preliminary efficient steady state solution problem proper classification nodes according temperature voltage drop ranges reduced network produced means clustering topological network transformations available static dynamic analysis due achievable reduction ratios possible lower order magnitudes computational cost good accuracies case study provided power grid millions nodes reduced factor electrical network thermal network
cloud computing evolutionary model distributed computing consists centralized data centers providing resources massive scalable computing major security challenges generation distribution usage encryption keys cloud systems one ways provide security proxy encryption scheme proposed semi trusted proxy transforms cipher text data sender cipher text data receiver without seeing underlying plaintext paper proposes new encryption scheme secure data sharing based trusted authority experimental results show scheme attains good performance previous schemes
integrated development construction projects complexity construction management increasing owing numerous participants resources involved necessary evaluate organizational performance construction projects considering objectives process construction benefits participants index system established paper based index system entropy method introduced calculate weight analytic hierarchy process ahp grey theory elected method organization performance evaluation research provides theoretical basis practical guidance improving management level construction projects achieve higher efficiency organization
paper presents proof concept metaphor fair trade validated alternative manage private information users privacy solution deals user privacy tradable good obtaining environmental services thus users gain access valuable services share personal information strategy combined optimistic access control transaction registry mechanisms enhances users confidence system encouraging share information consequent benefit community study results promising considering user responses regarding usefulness ease use information classification perception control mechanisms proposed metaphor
indoor air pollution closely related children health polybrominated diphenyl ethers pbdes dechlorane plus transmitted indoor dust along carbonyl compounds black carbon aerosol analysed five hong kong kindergartens results showed median levels indoor outdoor five kindergartens higher guidelines set world health organization indoor mass concentrations correlated outdoor four kindergartens pbdes dust dust detected dust samples fire retardant levels air correlated levels dust study median concentrations varied fold cooking events might caused concentrations rise indoors outdoors total concentrations carbonyls ranged indoors outdoors whilst formaldehyde abundant air carbonyl indoor carbonyl concentrations correlated outdoor carbonyls three kindergartens health risk assessment showed hazard indexes non cancer risks pbdes dps lower whilst non cancer carbonyl compounds ranged indoors outdoors human intake pbdes inhalation accounted total intake cancer hazard quotients hqs formaldehyde ranged indoors outdoors general indoor air pollution five hong kong kindergartens might present adverse effects children although different schools showed distinct pollution levels indoor air quality might improved artificial measures data useful developing feasible management protocol indoor environments elsevier ltd rights reserved
background calorie restriction retards aging increases longevity many animal models however unclear whether implemented humans without adverse effects body composition objective evaluated effect regimen body composition including influence sex body mass index bmi among participants enrolled calerie comprehensive assessment long term effects reducing intake energy multicenter randomized controlled trial design participants nonobese bmi adults aged randomly assigned libitum control ratio measures baseline included body weight waist circumference fat mass fat free mass ffm appendicular mass dual energy ray absorptiometry activity related energy expenditure aree doubly labeled water dietary protein intake self report values expressed means sds results group achieved significant decreases weight compared waist circumference compared compared ffm compared relative group group moreover ffm percentage body weight higher percentage lower group aree protein intake predicted preservation ffm men group lost significantly trunk fat ffm expressed percentage weight loss women group conclusions two years broadly favorable effects whole body regional adiposity could facilitate health span humans decrements ffm commensurate reduced body mass although men group lost ffm women percentage ffm men group higher baseline
detecting artificial targets aircraft satellite images significant military civil applications although performance improved use complicated features better learning methods effectively handling aircraft variations type pose size still challenging solve problem propose multiscale sliding window framework based aggregate channel features well designed features contain rich information also employ fast feature pyramids algorithm accelerate multiscale aircraft detection framework features trained cascade adaboost including multiple rounds bootstrapping leads improved overall accuracy two step nonmaximum suppression algorithm carefully designed based given set detections method shows competitive performance quickbird images resolution
background objective detailed body composition fat free mass examined idiopathic pulmonary fibrosis ipf investigated whether fat free mass index ffmi index lean body mass predicted survival methods forty four patients ipf enrolled study body composition assessed using direct segmental multi frequency bioelectrical impedance analysis degree correlation variables body composition variables forced vital capacity fvc survival examined results significant positive correlation ffmi fvc diffusion capacity lung carbon monoxide dlco min walk distance significant negative correlation age however significant correlation ffmi percentage predicted fvc dlco degree correlation similar observed bmi mean observation period survival analysis days univariate cox proportional hazard model showed several variables bmi associated significantly survival ffmi hazard ratio percentage predicted fvc significant factors multivariate model conclusion conclude ffmi significant independent predictor survival patients ipf
natural disasters constitute persistent threat economic welfare many places particularly developing countries disasters transform living circumstances provide evidence lead important changes individual preferences series experiments conducted rural thailand find tsunami led substantial longlasting increases risk aversion prosocial behavior impatience use gis data survey responses identify disaster impact showing community level individual level experiences appear affect preferences theoretically plausible ways findings important implications public policy efforts address natural disasters elsevier ltd rights reserved
field pretreatment free detection heavy metal ions organic polluted water important still challenging current water pollution emergency response systems report polyadenine dna mediated approach rationally designed alkyne coded surface enhanced raman scattering sers test kit enabling rapid simultaneous detection portable spectrometer impervious organic interferences formation thymine cytosine highly recognizable sers signals rapidly detected two different alkyne labeled gold nanoparticles aunps induced undergo controllable bridging upon addition low volume targets multiplex detection portable spectrometer limits detection reach respectively particular significance proposed containing raman reporters provide extremely effective solution multiplex sensing spectral silent region hyperspectral fairly intense optical noises originating lower wavenumber region inevitable complex ambient conditions
background aimscirculating testosterone usually reduced men cirrhosis comprehensive analysis androgen status circulating oestrogens little known associations circulating sex steroids aspects health population methodswe report data men cirrhosis low serum testosterone nmol calculated free testosterone pmol comprehensive circulating sex steroid profiles measured liquid chromatography mass spectrometry compared age matched controls relationships sex hormone levels severity liver disease biochemistry clinical outcomes assessed resultsserum oestrone oestradiol significantly elevated men cirrhosis compared controls median pmol pmol pmol pmol respectively serum oestrone correlated meld score correlation inversely correlated serum sodium correlation haemoglobin correlation correlations observed oestradiol serum testosterone levels inversely correlated meld score correlation positively handgrip strength correlation physical activity correlation haemoglobin correlation serum sodium dihydrotestosterone inversely correlated meld score correlation shared similar significant relationships testosterone conclusionlow serum androgens elevated serum oestrone oestradiol associated higher meld individual adverse health outcomes cirrhotic cohort men selected low testosterone serum oestrone may novel marker ill health population whether low androgens markers mediators ill health requires investigation
energy storage key challenge sustainable energy supply design new storage systems accurate representative thermal property measurements essential history method quick uncomplicated however numerous adaptations proposed years study methods classified critically assessed based mathematical formulation experimental configuration broadly categorized according one three assumptions regarding heat transfer coefficient natural convection constant either function time temperature negligible work proves addition heat transfer coefficient natural convection varies function time temperature demonstrated experimentally rigorous simulation proposed configurations thus history methods show promise precise unambiguous measurements eliminate convection making conduction dominant thermal resistance system techniques tailored different materials require simultaneous reference due use rigorous fundamental model compared lumped parameter approximation addition heat flux sensors quantify actual heat losses recommended absolute measurement certainty elsevier rights reserved
aim evaluated soluble urokinase type plasminogen activator receptor supar levels different stroke subtypes assessed prognostic value regarding year outcomes materials methods study included stroke patients males mean age years suspected cardioembolic stroke whose plasma supar concentration assessed altogether patients suffered stroke result cardioembolism large artery atherosclerosis small vessel disease large artery cardioembolic etiology cryptogenic stroke mean followup period years results supar concentration higher patients suffered stroke transient ischemic attack due large artery atherosclerosis compared small vessel disease elevated plasma supar concentration associated cause mortality followup period conclusion elevated plasma supar concentrations predicted cause mortality year follow ischemic stroke supar able differentiate patients cardioembolic stroke stroke types
background article aims survey describe injuries illnesses german team olympic games rio janeiro methods electronic documentation system injuries illnesses requiring treatment recorded evaluated injury illness defined physical symptom required medical attention impaired participation training competition classification distinguished type injury acute overload region type illness infections skin allergy etc results total treatments performed german team rio musculoskeletal related treatments performed lower limb treatments addressed back problems treatments performed due upper respiratory tract infections extrapolated athletes treatments required due illness treatments addressed musculoskeletal problems number treatments injuries illness almost identical addition less severe problems following serious injuries occurred lethal traumatic brain injury acute thigh compartment syndrome acl tear medial meniscal lesion antero lateral instability isolated acl tear stress fracture base third metatarsal bone acute lateral ankle instability joint dislocation infected bursa prepatellaris conclusions documentation system reliable injury illness surveillance multi sport events treatment numbers consistent summer games london reliable strategy assumed addition illnesses predominantly affecting upper respiratory tract system also recorded serious musculoskeletal injuries implicates need interdisciplinary setup medical team methods used data collection currently allow
present work addresses problem determining conditions impending slip state steady sliding linear elastic orthotropic layer half space respect rigid flat obstacle dynamically unstable words search conditions occurrence smooth exponentially growing dynamic solutions perturbed initial conditions arbitrarily close steady sliding state taking system away equilibrium state steady sliding state previously authors shown linear elastic isotropic half space compressed sliding respect rigid flat surface may get unstable flutter coefficient friction poisson ratio sufficiently large isotropic case able derive closed form analytic expressions exponentially growing unstable solutions well borders stability regions space parameters isotropic case two dimensionless parameters already simplest version orthotropy orthotropic transversally isotropic material seven governing parameters five independent material constants orientation principal directions orthotropy expressions become lengthy literally impossible manipulate manually orthotropic case addressed impossible solve simple closed form expressions therefore use computer algebra software required main commands indicated text
background little satisfactory evidence harm safety incidents patients terms lost potential health life years objective estimate healthy life years hlys lost due incidents english hospitals years compare burden across incidents estimate excess bed days research design study used cross sectional analysis medical records inpatients treated english hospitals patients types preventable incidents identified total attributable loss hlys estimated propensity score matching considering hypothetical remaining length quality life incident occurred results incidents resulted annual loss hlys excess bed days per population preventable pressure ulcers caused loss hlys excess bed days annually deaths low mortality procedures resulted lost life years bed days deep vein thrombosis pulmonary embolisms cost hlys bed days postoperative sepsis hip fractures central line infections cost hlys bed days discussion burden caused incidents roughly comparable burden multiple sclerosis dalys per hiv aids tuberculosis dalys cervical cancer dalys marked differences harm caused incidents despite public attention receive decision makers use results prioritize resources research effective interventions
pregnancy lactation associated osteoporosis plo rare form osteoporosis occurs last trimester postpartum far cases published leading symptoms severe low back pain less frequently hip pain many patients develop postpartum depression due inability care baby vertebral fractures therapeutic decision made individually teriparatid bisphosphonates seem best option report clinical course years year old patient plo suffered vertebral fractures severe physical limitations mental problems caused disease patient treated multimodal therapy including physiotherapy psychotherapy bisphosphonates given time onset symptoms diagnosis months fractures occurred following years physical mental condition significantly improved
present research investigated whether red attraction relation observed men viewing women may also observed regard women facial redness manipulated facial redness slightly increasing decreasing redness faces baseline pictures target women men judge attractiveness women also examined healthiness perceptions mediator redness attraction relation along several candidate mediator variables series experiments showed increased redness led increased ratings attractiveness decreased redness led decreased ratings attractiveness perceived healthiness documented mediator influence female facial redness male perceptions attractiveness mediation independent candidate mediator variables findings highlight importance attending facial coloration attraction relevant cue point interesting areas subsequent research
large number long span bridges constructed china motivates applications structural health monitoring shm technology many bridges equipped sophisticated shm systems mainland china hong kong china recently shm technology extended field test systems view shm serve tool develop methods life cycle performance design evaluation maintenance management bridges develop new structural analysis methods validation feedback shm results understand behavior bridges natural man made disasters rapidly assess damage loss structures large regions disasters earthquake typhoon flood etc hoped combining analytical methods numerical simulation small scale tests accelerated durability tests shm could become main engine driving development bridge engineering paper demonstrates viewpoint
background childhood cancer survivorship issues represent established public health challenge late adverse effects laes demonstrated time treatment dependent petale study multidisciplinary research project aiming comprehensively characterize laes identify associated predictive biomarkers childhood acute lymphoblastic leukemia call survivors methods call survivors treated sainte justine university health center dana farber cancer institution protocols eligible phase study participants underwent comprehensive clinical biologic psychosocial investigation targetingmetabolic syndrome cardiotoxicity bone morbidity neurocognitive problems quality life issues whole exome sequencing performed participants subjects identified extreme phenotype phase recalled additional testing phase results phase included survivors recall rate participants completed phase recall rate survivors agreeing participate phase similar refused terms relapse risk profile radiotherapy exposure age time study participants however tended slightly older diagnosis years old higher proportion female agreeing participate compared males conclusion petale study contribute comprehensively characterize clinical psychosocial biologic genomic features call survivors using integrated approach expected outcomes include lae early detection biomarkers long term follow guidelines recommendations physicians health professionals
certain types joint injuries common athletes known high association development osteoarthritis post traumatic osteoarthritis ptoa especially debilitating due earlier onset traditional predisposition affect younger active population five common athletic injuries demonstrated risk factors development include acl rupture meniscus tear glenohumeral instability patellar dislocation ankle instability though mechanisms responsible development ptoa entirely clear certain kinematic biologic mechanical factors implicated addition increased emphasis development new methods detect early changes patients known risk factors early intervention may prevent development end stage new imaging modalities well identification specific biomarkers may allow earlier detection though developments hold promise entirely known steps take today prevent future development even early detection orthopaedic research society published wiley periodicals inc orthop res
increased popularity building information modeling bim application construction eco friendly green buildings given rise techniques evaluating green buildings constructed using bim features existing bim based green building evaluation techniques mostly rely externally provided evaluation tools pose problems associated interoperability including lack data compatibility amount time required format conversion overcome problems study sets develop template green template evaluating embodied environmental impact using bim design tool part bim based building life cycle assessment lca technology development firstly bim level detail lod determined evaluate embodied environmental impact constructed database impact factors embodied environmental impact major building materials thereby adopting lca based approach libraries major building elements developed using established databases compiled evaluation table embodied environmental impact building materials finally green template developed embodied environmental impact evaluation tool case study performed test applicability results green template based embodied environmental impact evaluation test building validated actual quantity takeoff takeoff reliability confirmed effective error rate study aims develop system assessing impact substances discharged concrete production process six environmental impact categories global warming gwp acidification eutrophication abiotic depletion adp ozone depletion odp photochemical oxidant creation pocp using life cycle assessment lca method achieve proposed lca method specifically applicable concrete tailored korean concrete industry adapting iso standards suit korean situations
present paper novel automatic gain control pre amplifier hearing aid device proposed analyzed proposed design utilizes feedback feed forward loop order control gain device input output thresholds accommodated provide dual control weak input signal amplified three modes high gain low input low gain high input forms basis amplification measured average power dissipation complete pre amplifier dual power supply technology node frequency operation khz
many studies deal impact prevention campaigns whatever method used postulate people take campaign consideration soon exposed cognitive dissonance theory festinger postulates principle selective exposure people tend expose consistent information strengthen attitude behavior avoid inconsistent one avoiding inconsistent information prevents threatening position could modify attitude goal research consists verifying selective exposure effect concerning smoking prevention using measure implicit attitude research conducted professional training institute participants recruited pretext consultation part training design addictions either employees trainees institute forty four smokers non smokers took part experiment precise prevention thematic among six addictions would interest order construct new training formation program dealing dangers addiction harmful effects tobacco alcohol drugs etc people asked kind topic would interest attitudes behavior toward smoking evaluated evaluate smoking attitudes used explicit attitude toward smoking scale ats etter implicit measure single category implicit association test personalized iat bardin smoking habits also recorded results revealed smokers implicit attitude less negative non smokers implicit attitude smokers also predicts selective exposure attitude positive less people would like expose smoking prevention information last smokers already considered quitting inclined expose information smokers results support hypothesis effect attitudes explicit implicit expression needs context smoking prevention training design societe francaise psychologie published elsevier masson sas rights reserved
motorcycles one dangerous means transportation death toll higher others due inherent vulnerability motorcycle drivers latest strategies advanced driving assistance systems adas trying mitigate problem applying advances modern technologies road transport paper presents two different approaches motorcycle protection based two modern available technologies adas computer vision vehicle vehicle communication first approach based data fusion laser scanner computer vision providing accurate obstacle detection localization based laser scanner obstacle classification using computer vision laser second approach based hoc technology provides detection case occlusion visual sensors technologies tested presented work performance comparison given tests performed different driving situations allows measure performance every algorithm limitations based empirical scientific foundations conclusions presented work help foster expert systems automotive sector providing discussion viability impact systems real scenarios elsevier ltd rights reserved
libraries collections specially rare special books collections cultural good historical sociological point view however book even libraries clearly among items preserved brazilian constitution international organizations lack discussion legal cover bibliographic collection heritage preserved absence overall view prejudice preservation library collections based legal texts dealing book libraries paper discusses role libraries preservation historical collections within public institutions
high quality education topics concerning behavior control electrical machines power electronics taught theoretically also practical manner hard software tools necessary fulfil obligation nevertheless commercial systems partially lack functionality full accessibility implement custom solutions obligatory research education domain therefore digital signal processing system presented allows full modification every used device hardware software
besides explanatory variables parenting styles parental violence might also responsible setting path towards overweight obesity childhood association consistently observed adults findings adolescents still remain scarce inconsistent therefore goal study add evidence topic children adolescents analyses based sample german ninth grade students analyze associations parenting dimensions weight status non parametric conditional inference trees applied three gender specific pathways heightened risk overweight obesity observed female adolescents report experienced severe parental physical abuse medium high parental warmth childhood male adolescents report experienced low medium parental monitoring childhood second pathway male adolescents pronounced families receive welfare importance promoting parenting styles characterized warmth lack physical abuse also discussed one studies examining association parenting dimensions parental physical abuse weight status adolescence future studies include even parenting dimensions well parental physical abuse levels order detect untangle gender specific effects weight status
allergic bronchopulmonary aspergillosis abpa pulmonary disorder often occurs patients asthma cystic fibrosis characterized hypersensitivity response allergens fungus aspergillus fumigatus patients growth fumigatus hyphae within bronchial lumen triggers immunoglobulin ige mediated hypersensitivity response results airway inflammation bronchospasm bronchiectasis published studies prevalence abpa patients since clinical features condition overlap significantly abpa challenging diagnose remains underdiagnosed many patients diagnosis abpa patients sought evidence clinical radiologic deterioration attributable another etiology markedly elevated total serum ige level steroid therapy evidence fumigatus sensitization management abpa involves use systemic steroids reduce inflammation modulate immune response patients respond steroids tolerate antifungal agents used reduce burden fumigatus allergens recent studies suggest omalizumab may effective option reduce frequency abpa exacerbations patients randomized controlled trials needed better establish efficacy omalizumab managing patients abpa
introduction atopic dermatitis chronic relapsing pruritic inflammatory skin disease skin barrier defects abnormal immune reactions contribute complex disease current therapeutic guidelines recommend use moisturizers good skin care allergen avoidance first line approach patients respond well measures topical corticosteroids calcineurin inhibitors severe cases systemic immunosuppressive agents mostly used areas covered review summarizes patent applications small molecule compounds treatment atopic dermatitis date substances include compounds targeting skin barrier filaggrin production promoters filaggrin breakdown products compounds improving stratum corneum lipid barrier including pseudoceramides anti inflammatory compounds pde inhibitors crth inhibitors chemokine receptor antagonists inhibitors chymase compounds specifically targeting itch trp agonists opioid ligands serotonin histamine antagonists expert opinion recent advances understanding pathogenic mechanisms atopic dermatitis created strong rationale design targeted therapeutics emerging compounds target inflammation pruritus probably broader therapeutic utility compounds specific skin barrier corrective therapies much fewer bear strong potential actually prevent inflammation
categorizations multiracial individuals provide insight psychological mechanisms driving social stratification studies explored interplay cognitive motivational underpinnings categorizations present study integrated research racial essentialism belief race demarcates unobservable immutable properties negativity bias tendency weigh negative entities heavily positive entities explain people might exhibit biases categorization multiracial individuals theorized racial essentialism dispositional study experimentally induced study led categorization black white multiracial individuals black among individuals evaluating black people negatively white people findings demonstrate fundamental cognitive motivational biases interact influence categorization multiracial individuals
whereas traumatic brain injury tbi results widespread disruption neural networks changes regional resting state functional connectivity patterns insult remain unclear specifically little known chronology emergent connectivity alterations whether persist critical recovery window used resting state functional magnetic resonance imaging seed voxel correlational analyses cross sectional longitudinal designs probe intrinsic connectivity patterns involving posterior cingulate cortex pcc hippocampi regions shown important default mode network dmn vulnerable neuropathology total participants chronic stage moderate severe tbi healthy controls included cross sectional study longitudinal analyses included individuals tbi group data approximately months injury subacute available overall results indicated dissociable connectivity trajectories pcc hippocampi recovery tbi pcc alterations characterized early hypersynchrony anterior dmn gradually reduced hippocampal changes marked increasing synchrony proximal cortex subcortex pcc also showed increasing antiphase synchrony posterior attentional regions hippocampi showed decreasing antiphase synchrony frontal attentional regions antiphase synchrony hippocampus dorsolateral prefrontal cortex subacute stage tbi positively associated attentional performance neuropsychological tests subacute chronic stages findings highlight heterogeneity regional whole brain connectivity changes tbi suggest residual connectivity alterations exist clinically stable phase tbi parallels chronicity observed effects findings neurodegenerative disease discussed context potential long term outcomes tbi
although tea consumption reported various health benefits humans association health related quality life hrqol investigated directly aimed examine relationship tea consumption hrqol among older chinese adults analyzed community based cross sectional data older chinese individuals aged years older participated weitang geriatric diseases study information tea consumption hrqol assessed european quality life dimensions collected questionnaires estimated relationship tea consumption index score using linear regression models association tea consumption self reported health problems using logistic regression models index score higher habitual tea drinkers counterparts multivariate linear analyses controlling socio demographic conditions health conditions lifestyle habits differences index score individuals without tea drinking habits confidence interval multivariate logistic analyses habitual tea drinking inversely associated reporting problems dimensions mobility odds ration pain discomfort anxiety depression associations evident black oolong tea green tea habitual tea consumption associated better hrqol older adults
using field programmable gate array fpga development board digital signal processor dsp builder phase amplitude conversion principle low cost system measuring amplitude amplitude amplitude phase distortion curves radio frequency power amplifiers pas presented state art based measurements preliminary studies distortion curves discussed full digital control test bed simulated emulated matlab simulink introduced recalculate known measurements stored look table lut finally low cost system comprises memory polynomial model mpm involves nonlinearity order memory effects real pas elsevier rights reserved
objective analyzing factors associated urinary incontinence among women submitted urodynamic testing method cross sectional study women attended urological center data analyzed using univariate multivariate statistics results white women overweight menopausal drink coffee sedentary vaginal birth episiotomy underwent kristeller maneuver urethral hypermobility statistical association found weight change menopause intrinsic sphincter deficiency isd detrusor instability gynecological surgery isd hysterectomy types physical activity mixed conclusion interventions guidance preventing strengthening pelvic muscles directed women present weight changes sedentary menopausal women undergone hysterectomy gynecological surgery studies pelvic strengthening methods needed order take account profile needs presented women
work describes concept shape memory polymer smp mandrel manufacture complex shaped filament wound carbon composite air duct mandrel designed fabricated tested verify shape recovery extraction characteristics manufacturing composite structure finite element model developed predict shape recovery overall deformation behavior due combination pressure temperature profiles used molding agreement deformations predicted finite element model ones measured smp demonstrator good show feasibility smart material mandrel used production composite structures complex ducted forms demonstrator pan carbon epoxy filament wound composite air duct manufactured capability smp mandrel verified hot gun extraction process elsevier ltd rights reserved
control applications often implemented highly cost sensitive resource constrained embedded platforms microcontrollers small chip memory typically control algorithms designed using model based approaches details implementation platform completely ignored result optimizations integrate platform level characteristics control algorithms design largely missing emergence cyber physical systems cps oriented thinking lately strong interest design control algorithms implementation platforms leading work networked control systems computation aware control algorithms design however far work integrating characteristics memory architecture design control algorithms paper first time show accounting impact chip memory cache reuse performance control applications motivates new techniques control algorithms design leads significant improvement quality control given resource availability efficient implementations embedded control applications believe paper opens variety possibilities memory related optimizations embedded control systems pursued researchers working computer aided design cps
indebtedness emerged new social risk among europeans consequence economic recessions associations health disability poorly understood study utilises longitudinal register based data assess associations indebtedness disability retirement severely indebted people identified finnish credit information register indebted person one matched control retrieved population register total register data socio demographics health related factors pensions used analyse incidence disability pensions due different diagnoses among indebted people controls period using cox regression analysis analyses showed indebtedness strongly associated risk disability retirement diagnostic groups associations stronger among women among men adverse effects indebtedness health disability acknowledged addition standard socio demographic indicators debtor status may add knowledge predictors poor health policymakers adopt measures prevent indebtedness overcome harmful effects
high resolution transmission electron microscopy analyses carried understand microstructure ultra thin oxide film grown native amorphous alo coated alloy substrate oxide film found non uniformly thick thicknesses varying occasionally oxide found diffuse alloy substrate forming oxide thicknesses overall oxide film found consist mixed amorphous poly crystalline intermediate amorphous crystalline transition regions crystalline regions consisting mostly mgo diffused oxide regions alloy substrate coated gamma alo observations compared experimental results obtained using angle resolved ray photoelectron spectroscopy analysis thermodynamic predictions growth ultra thin oxide film due dry thermal oxidation alloy substrates
increase cardiovascular disease cvd risk rheumatoid arthritis well known however appropriate management elevated risk rheumatology clinics less clear purpose review critically reviewing literature published within past years aim clarify current knowledge gaps regarding cvd risk management recent findings examine recent guidelines recommendations evidence discuss three approaches specificmanagement including treat target andmedication management assessment comprehensive individual risk targeting traditional cvd risk factors hypertension smoking hyperlipidemia diabetes obesity physical inactivity population level considering visits occur specialty clinics research needed regarding evidence based strategies manage reduce cvd risk summary review highlights clinical updates including cardiology international professional society guidelines successful evidence based population approaches primary care novel opportunities rheumatology care reduce cvd risk
three dimensional data structures batch process data infra red spectral measurements usually contain inconsistent trajectories various durations quality case batch process data modeling methods require data batches duration spectral data peaks might shifted one sample another due unaccounted sources variation inconsistencies usually resolved trajectory alignment synchronization methods paper first review deficiencies existing approaches next constrained selective derivative dynamic time warping csdtw method proposed perform automatic alignment trajectories different conventional methods csdtw preserves key features characterizes batch apply warping regions least impact trajectory characterization proposed warping technique applied industrial simulated datasets demonstrate effectiveness
division summation sigma current control one cycle voltage regulation ocvr surface mounted permanent magnet synchronous generator spmsg drive developed advancement motor manufacturing motor design digital control units power electronics converters permanent magnet synchronous generator pmsg broadly applied electric vehicles hybrid electric vehicles flywheel energy storage system wind power generators satisfactory current control scheme pmsg significant achieve desired generating performance sigma current control proposed derived conventional space vector modulation two phase modulation simplification complex self mutual inductances pmsg demonstrated proposed current control achieve current waveform tracking simplification winding inductances without parameter designing procedure feedback controller computation time microcontroller reduced via proposed current control scheme processing times conventional control sigma control compared moreover link voltage well regulated proposed ocvr method reduce complexity voltage controller design merits two methods easy implement parameter designing procedure feedback controller unnecessary addition system stability parameter sensitivity analyzed evaluated measured waveforms verify current tracking torque ripple dynamic performance voltage regulation spmsg drive reduction switching losses verified calculation results
paper presents teaching approach aiming give students chance applying theoretical concepts virtual environments thereby overcoming limitations overcrowded classes large groups engineering undergraduates using available testing equipment proposed approach deals enhancing self learning one common tests used materials engineering civil engineering namely compression test concrete samples achieve goal two didactic propose computational tools developed virtual laboratory video tutorials vts furthermore two different teaching learning experiences compared paper using actual laboratory using virtual environments vts using virtual environments cases use virtual tools improves student learning outcomes especially resources fulfill lack real equipment besides results survey questions show high motivation virtual environments awake assessment results reflect increase students marks american society civil engineers
give optimal size representation elements trace zero subgroup picard group elliptic hyperelliptic curve genus respect field extension prime degree representation via coefficients rational function compatible scalar multiplication points provide efficient compression decompression algorithms complement implementation results discuss detail practically relevant cases small genus extension degree compare known compression methods
studies investigated expectations fatherhood men without children none within age bracket often associated new fatherhood therefore objective qualitative study gain depth understanding young men beliefs perceptions role interpretative phenomenological analysis ipa interview transcripts identified key themes contemporary model father perceived threat life know central theme unforeseeable future analysis revealed participants held broad expectations emotionally physically involved well economically responsible fathers views often lacked specificity consideration meaning practical notions expectations could fulfilled explain lack development men conceptualization fatherhood across emerging adulthood hegemonic masculinity identity theory life course perspectives current study provides rationale promoting increased discussion around fatherhood preconception period help lessen turbulent nature men transition pregnancy
access recovery atr substance abuse mental health services administration samhsa funded initiative offers mix clinical supportive services substance abuse atr clients choose services help overcome barriers road recovery recovery consultant provides vouchers helps link client community resources one atr goals provide services involved criminal justice system hopes addressing substance abuse issues could reduce subsequent criminal behaviors study examines goal looking recidivism among sample clients one state atr program returned community incarceration results suggest differential effects service selections subsequent recidivism however significant differences recidivism rates among agencies provided atr services agencies resources focus prisoner reentry better recidivism outcomes focus substance abuse services
ibogaine plant alkaloid used anti addiction drug dozens alternative medicine clinics worldwide recently alarming reports life threatening cardiac arrhythmias cases sudden death associated ingestion ibogaine accumulated using whole cell patch clamp recordings assessed effects ibogaine main metabolite noribogaine action potentials human ventricular like cardiomyocytes derived induced pluripotent stem cells therapeutic concentrations ibogaine long lived active metabolite noribogaine significantly retarded action potential repolarization human cardiomyocytes findings represent first experimental proof ibogaine application entails cardiac arrhythmia risk humans addition explain clinically observed delayed incidence cardiac adverse events several days ibogaine intake conclude therapeutic concentrations ibogaine retard action potential repolarization human heart may give rise prolongation interval electrocardiogram cardiac arrhythmias
financial prosocial biases favor attractive adults documented labor market social transactions everyday life studies involving experimental economic games according taste based discrimination model developed economists attractiveness related financial prosocial biases result preferences prejudices similar displayed toward members particular sex racial ethnic religious group explanations proposed economists social psychologists maintain attractiveness marker personality intelligence trustworthiness professional competence productivity evolutionary psychologists argued attractive adults favored preferred sexual partners evidence stereotypes attractive people causally related financial prosocial biases toward weak nonexistent consistent evolutionary explanations biases favor attractive women appear consistent stronger favor attractive men biases consistently reported interactions opposite sex sex individuals evolutionary explanations also account increased prosocial behavior situations attractive individuals simply bystanders finally evolutionary explanations consistent psychological physiological behavioral changes occur individuals exposed potential mates facilitate expression courtship behavior increase probability occurrence mating therefore multiple lines evidence suggest mating motives play important role driving financial prosocial biases toward attractive adults previously recognized
study model magnetic system triplet ground state coupled two temperature baths varying temperatures generate non thermal electronic distributions create additional coherences density matrix system thus thermally induced magnetic response goes beyond simple picture majority minority population dynamics furthermore discuss influence temperature induced relaxation effects dynamics induced optical perturbation quantum system elsevier rights reserved
study design retrospective study objective study opted clarify remaining issues lumbar lordosis regard physiological values age sex facet joint arthritis orientation using computed tomography scans summary background data recent studies questioned whether really decreases age study sample sizes rather small mostly based rays hyperlordosis increases load transferred fjs seems plausible hyperlordosis may lead arthritis lower lumbar spine methods retrospectively analyzed scans individuals mean age range years presented traumatology department underwent whole body scan evaluated superior endplates fjs lumbar spine evaluated arthritis orientation results mean degrees degrees range degrees increased age significant difference age groups significant difference females males degrees showed significant linear association arthritis sagittal orientation logistic regression analysis cutoff point degrees conclusions largest based study fjs significantly increases age novelty finding hyperlordosis significantly associated arthritis sagittal orientation lower lumbar spine thus hyperlordosis may present back pain patients may benefit surgical correction example setting trauma
work present improved sliding mode control ismc technique designed implemented control manipulator sliding mode control smc well known nonlinear robust method controlling systems presence uncertainties disturbances systems complex dynamics manipulators despite good property difficult implement method manipulator complex structure three degree freedom complicated massive equation chattering phenomenon property smc control inputs chattering phenomenon eliminated using effective algorithm called ismc implemented manipulator using low cost control board based arm microcontroller high accuracy memory carrying load considered uncertainty manipulator dynamic load carrying capacity dlcc considered robot performance criterion showing robustness controller results simulations experiments show proposed approach good performance suitable practical applied manipulators
aim program access review trending information evaluate correlation symptoms patients heart failure partners trial elaborated multiparametric model prediction acute decompensation advanced heart failure patients based periodical office data download cardiac resynchronisation devices study evaluated ability partners criteria detect initial decompensation population moderate heart failure patients remote monitoring methods retrospectively applied partners criteria transmissions patients median follow months range months enrolled programme telemedicine cardiac resynchronisation therapy tested ability score based criteria predict acute clinical decompensation occurring days following transmission results cases acute heart failure diagnosed index transmission area curve auc score diagnosis acute decompensation confidence interval best score cut consistent results partners score sensitivity specificity odds ratio events conclusions retrospectively applied remote monitoring transmissions arranged score partners criteria could identify patients subsequently developed acute decompensation results warrant prospective studies applying partners criteria remote monitoring
objectives determine immediate pain relief effect low level laser therapy sports injuries athletes degree pain relief therapy design double blind randomized comparative clinical study methods participants college athletes motion pain defined site participants randomized two groups tested placebo laser therapy administered determine pain intensity painful action laser irradiation using modified numerical rating scale post therapeutic modified numerical rating scale score subtracted pre therapeutic modified numerical rating scale score determine pain intensity difference rate pain intensity difference pre therapeutic modified numerical rating scale calculated pain relief rate results low level laser therapy effective laser group whereas effective placebo group indicating significant difference favor laser group pain relief rate significantly higher laser group placebo group respectively difference pain relief rate conclusions low level laser therapy provided immediate pain relief effect reducing pain effective pain relief participants sports medicine australia published elsevier ltd rights reserved
studies shown direct link memory emotionally salient experiences false memories particular emotionally arousing material negative positive valence enhanced reality monitoring compared neutral material since emotional stimuli encoded contextual details thereby facilitate distinction presented imagined stimuli individuals schizophrenia appear impaired reality monitoring memory emotional experiences however relationship emotionality remembered material false memory occurrence yet studied study patients healthy adults completed false memory task everyday episodes composed photographs depicted positive negative neutral outcomes results showed patients schizophrenia made higher number false memories normal controls resulting erroneous inferences interact plausible script consistent errors patients neutral episodes yielded higher degree errors positive negative episodes affective information reduces probability generating causal errors healthy adults patients suggesting emotional memory impairments may contribute deficits reality monitoring schizophrenia affective information involved
study develops integrated multi scale model pilot concentrated high intensity electric field chief system using finite element method fem chief system novel non thermal pasteurization technology uses medium low voltage frequency power supply offers satisfactory pasteurization results liquid food juice milk model study provides accurate predictions fluid behavior electric field distribution temperature profile validated using experimental results results model shows chief system provide electric field power supply enabling log reduction bacteria kill furthermore recommendations optimizations made based modeling results would benefit process scale design published elsevier ltd
rapid development latest distributed computing paradigm cloud computing generates highly fragmented cloud market composed numerous cloud providers offers tremendous parallel computing ability handle big data problems one biggest challenges multiclouds efficient workflow scheduling although workflow scheduling problem studied extensively still primal works tailored multicloud environments moreover existing research works either fail satisfy quality service qos requirements consider fundamental features cloud computing heterogeneity elasticity computing resources paper scheduling algorithm called multiclouds partial critical paths pretreatment mcpcpp big data workflows multiclouds presented algorithm incorporates concept partial critical paths aims minimize execution cost workflow satisfying defined deadline constraint approach takes consideration essential characteristics multiclouds charge per time interval various instance types different cloud providers well homogeneous intrabandwidth heterogeneous interbandwidth various types workflows used evaluation purpose experimental results show mcpcpp promising
paper investigate soliton rogue wave solutions dimensional fourth order nonlinear schrodinger equation describes spin dynamics heisenberg ferromagnetic spin chain bilinear biquadratic interactions equation exists gauge transformation converts nonzero potential lax pair constant coefficient differential equations solving equations vector solutions nonzero potential lax pair obtained condition modulation instability plane wave solution also given linear stability analysis present determinant representations soliton solutions via darboux transformation nth order rogue wave solutions via generalized profiles solitons rogue waves analyzed respect lattice parameter sigma respectively sigma greater certain value marked sigma one soliton velocities increase increase sigma sigma sigma one soliton velocities decrease increase sigma time equal zero sigma effect interactions two solitons equal different choices sigma lead different two soliton velocities giving rise different interaction regions widths first order rogue waves become bigger decrease sigma amplitudes depend sigma second order rogue waves composed three first order rogue waves whose widths get wider decrease sigma amplitudes depend sigma
background study aimed investigate associations histamine receptor hrh gene polymorphisms oral antihistamine efficacy treatment allergic rhinitis patients methods total patients selected case group healthy individuals recruited control group single nucleotide polymorphisms snps hrh gene detected using direct sequencing serum immunoglobulin ige specific ige eosinophil cationic protein ecp levels measured enzymelinked immunosorbent assay elisa clinical efficacy evaluated visual analogue scale vas occurrence adverse reaction recorded results significant differences distribution frequencies mutant genotype allele mutant genotype allele mutant genotype allele case control groups patients mutant genotype patients mutant genotype higher specific ige ecp levels vas scores treatment lower incidence adverse reactions total effective rate genotype genotype respectively however differences found patients mutant genotype genotype conclusion findings provide evidence hrh polymorphisms may associated risk efficacy antihistamines treatment patients ars aaoa llc
platonic world mathematical facts contain precisely observe large uninteresting value selection totality smaller interesting independent alternatives challenge mathematical platonism suggest universality mathematics may prejudice illustrate contingent aspects classical geometry arithmetic linear algebra making case call mathematics always contingent
photodriven hydrogen production good strategy solar energy utilization work use water soluble negatively charged polythiophene derivative photosensitizer produce hydrogen aqueous solution containing methyl viologen ethylenediaminetetraacetic acid disodium salt edta colloidal platinum catalyst upon exposure xenon lamp natural sunlight supramolecular assembly dis assembly processes cucurbit uril used reversibly turn turn hydrogen generation polymer system research offers proof concept control hydrogen generation demand advantage hydrogen utilization storage
models crucial engineering design process used optimization design parameters prediction performance thus models significantly reduce design development optimization costs paper proposes novel equivalent electrical model darrieus type vertical axis wind turbines dtvawts proposed model built mechanical description given paraschivoiu double multiple streamtube model based analogy mechanical electrical circuits work addresses physical concepts theoretical formulations underpinning development model highlighting working principle dtvawt step step development model presented assessment purposes simulations aerodynamic characteristics corresponding electrical components performed compared
behavioral weight loss bwl treatments result suboptimal weight losses many individuals impulsivity appears maintenance factor obesity yet studies examined impulsivity predictor outcomes bwl examined specific facets impulsivity inhibitory control delay discounting moderators outcome bwl overweight adults randomized standard behavioral treatment sbt acceptance based behavioral treatment abt hypothesized impulsivity would inversely associated weight loss association impulsivity outcome would attenuated abt condition poorer general inhibitory control predicted lower percent weight lost months across conditions trend level negative impact low inhibitory control weight loss attenuated assignment abt versus sbt treatment condition trend level also moderated impact delay discounting food specific inhibitory control percent weight loss greater impulsivity benefitted abt results reveal potential pattern impulsivity reduces benefit derived sbt abt research moderating effect impulsivity necessary inform development targeted treatments clinically meaningful subtypes patients elsevier ltd rights reserved
study assessed effects psycho educational intervention direct care workers person centredness morning care residents dementia controlled pretest posttest study conducted four aged care facilities direct care workers female mean age two experimental facilities received psycho educational intervention comprising person centred care competences stress management skills control facilities received education intervention without stress support total video recorded morning care sessions coded using global behaviour scale groups reported significantly higher scores eight items global behaviour scale global behaviour scale total score posttest global behaviour scale total score improvements higher experimental group values close significance findings suggest psycho educational intervention may increase care workers person centredness research needed explore long term sustainability extent benefits workers residents
variable coefficient nonlinear schrodinger nls type models used describe certain phenomena plasma physics nonlinear optics arterial mechanics bose einstein condensation article coupled variable coefficient cubic quintic nls equations external potentials non kerr fibre investigated via symbolic computation similarity transformations relevant constraints coefficient functions obtained based transformations equations transformed coupled cubic quintic nls equations constant coefficients nonautonomous soliton solutions derived propagation interaction nonautonomous solitons non kerr fibre investigated analytically graphically soliton solutions related group velocity dispersion external potentials different choices parabolic cubic periodically oscillating solitons obtained different choices see dromion like structures nonautonomous solitons smooth step like oscillator frequency profiles name
contemporary journalism explores new formulas international level prepare information means transmedia story telling mobile devices multimedia hypertextual communication enriched efficient contents involve universal formulas information output seeks audience participation comments retransmissions means social networks generate model proactive television consumption social audience paper features revision journalism transmedia communication innovation within digital ecosystem possible work journalism texts images audio files interactive videos computer graphics gif files maps links etc formats invite audience participate genuine digital artworks line reports documentaries viewed second screens transmedia communication based informative stories developed multiple platforms contributes different way global understanding story new narrative selecting suitable channels achieve added value communication frontiers hybridization languages technological convergence keys truly silent revolution point towards emerging model contemporary journalism
visible light active hematite based photoelectrode platform suppressing amyloid self assembly vitro reported upon illumination light emitting diode anodic bias hematite photoanode generates reactive radical species superoxide ions hydroxyl radicals via photoelectrocatalytic process according analyses hematite photoanode exhibited strong inhibitory effect aggregation visible light illumination anodic bias found hole derived radicals played significant role oxidizing peptides effectively blocked aggregation efficacy photoelectrocatalytic inhibition aggregation enhanced introducing cobalt phosphate catalyst hematite photoanode facilitated separation electron hole pairs verified bare hematite photoanodes biocompatible effective reducing aggregation induced cytotoxicity
purpose nocturia common bothersome older adults especially also incontinent since nocturnal polyuria major contributor examined factors associated nocturnal polyuria population identify possibly amenable intervention materials methods analyzed baseline data previously completed studies urge urinary incontinence studies involved women mean age years also completed day voiding diaries participants nocturnal polyuria index greater categorized nocturnal polyuria nocturnal polyuria index nocturnal urinary volume per hour urine volume associations nocturnal polyuria various demographic clinical sleep related parameters determined results overall participants nocturnal polyuria multivariable regression analysis revealed age body mass index use angiotensin converting enzyme inhibitor angiotensin receptor blocker time spent bed duration first uninterrupted sleep independent correlates nocturnal polyuria participants larger nocturnal excretion reported shorter duration uninterrupted sleep first awakening void worse sleep quality despite spending similar time bed conclusions body mass index use angiotensin converting enzyme inhibitor angiotensin receptor blockers time bed duration uninterrupted sleep first awakening void independently associated nocturnal polyuria older women urge urinary incontinence potentially modifiable findings also confirm association sleep nocturnal polyuria studies explore whether interventions reduce nocturnal polyuria increase duration uninterrupted sleep first awakening void would help improve sleep quality population thereby reduce eliminate need sedative hypnotics
gitelman syndrome characterized hypokalemia hypomagnesaemia hypocalciuria metabolic alkalosis neurological symptoms association type diabetes rare described case reports report patient unusual combination type diabetes mellitus erythrocytosis year old male type diabetes intensive insulin therapy poor compliance presented complaint headache physical examination blood pressure mmhg neurological deficit proximal muscle weakness previous medical history obstructive sleep apnea heart lung disease negative smoking history laboratory tests revealed erythrocytosis hemoglobin level hematocrit level cranial magnetic resonance imaging normal evidence hypovolemia hematological workout excluded polycythemia vera chronic myeloid neoplasm bone marrow aspiration revealed hypercellular marrow increased erythroid precursors megakaryocytes granulocytes reticulin stain grade zero iron accumulation iron stain radiologic evidence kind erythropoietin producing tumors echocardiography normal serum insulin like growth factor levels endogenous androgens within normal limits therapeutic phlebotomies symptoms improved hemoglobin patient besides type diabetes complicated idiopathic erythrocytosis deleterious effects hemodynamic status patient
model based fault diagnosis attracted considerable attention researchers developers flight control systems thanks hardware simplicity cost effectiveness however airplane model adopted commonly fault diagnosis exists theoretically linearized approximation reason uncertainties system non linearity subjectivity degrade fault diagnosis results paper propose novel actuator fault diagnosis scheme flight control systems based model identification techniques scheme system identification achieved linear model uses closed loop subspace model identification algorithm non linear model uses extended state observer neural networks basis current actuator fault estimated using adaptive two stage kalman filter finally non linear six degree freedom model airplane simulated matlab simulink environment effectiveness proposed scheme verified fault diagnosis tests
square kilometre array ska ambitious project aimed build radio telescope enable breakthrough science possible current facilities next years long expected operational period maintenance telescope manager ska element responsible coordination elements composing telescope dishes mid frequency low frequency aperture arrays plays crucial role overall ska operation challenge represented technological evolution hardware software rather fast nowadays last years instance new operating systems born well new technologies data storage calculation dealing changing environment deserves therefore deep analysis terms maintenance spite importance hardware maintenance software maintenance actually real challenge given system almost entirely composed software applications computer science indeed almost impossible build software need changed time new requirements emerge old requirements change application lifetime errors discovered performance must improved reasons management software changes critical maintain value software developed especially complex system like ska paper maintenance ska hardware software presented respect operational related maintenance process organizational related logistic support aspects
paper presents tool developed support teaching computer programming practical laboratory sessions tool implemented plugin eclipse ide deployed distributed manner provide real time monitoring students activity
africa population growing faster pace growth megacities rate urbanization rapid alongside economic growth expected robust future altogether pose serious challenges energy system africa condition makes development renewables res necessity continent though continent well endowed res least developed deployed partly due limited research development sector particularly macroeconomic implications res thoroughly studied continent leaves big literature gap continent motivates current study investigate macroeconomic implications res using ghana case study country well endowed res one continent integrated res overall energy policy specifically study examined implications res concentration electricity price uncertainty investigated persistent profile effect system wide individual shocks equilibrium relations finally decomposed variance electricity price permanent transitory components explained drives trends elsevier ltd rights reserved
objective evaluate facial soft tissue changes use twin block appliance class division malocclusion patients materials methods several electronic databases pubmed medline medline process non indexed citations cochrane databases embase web science lilacs searched help senior health sciences librarian abstracts appeared fulfill initial selection criteria selected consensus original articles retrieved article references hand searched possible missing articles clinical trials assessed facial soft tissue changes use twin block appliance without surgical intervention syndromic characteristics considered comparable untreated control group required factor normal growth changes results two articles fulfilled selection criteria quantified facial soft tissue changes although statistically significant changes soft tissue profile found magnitude changes may perceived clinically significant changes produced upper lip seem controversial although study sounder methodological quality report significant changes change anteroposterior position lower lip soft tissue menton improvement facial convexity found conclusions three dimensional quantification soft tissue changes required overcome current limitations understanding soft tissue changes obtained use twin block appliance class division malocclusion patients
hiv aids epidemic continues persist particular among race sexual orientation gender minority populations pre exposure prophylaxis prep using antiretroviral medications hiv prevention effective option uptake prep slow sociocultural barriers using prep largely underemphasized yet potential stall uptake therefore warrant understanding order assess relationships potential barriers prep prep stigma conspiracy beliefs interest prep black men transgender women sex men bmtw white mtw wmtw surveyed gay pride event large southeastern city bivariate multivariate logistic regression analyses completed examine factors associated prep interest among full sample moderate levels prep awareness low levels use observed believing prep people promiscuous stigma belief strongly associated lack interest using prep individuals endorsed belief likely report sexual risk taking behavior conspiracy beliefs related prep reported among large minority sample frequently reported among bmtw wmtw given strong emphasis use biomedical strategies hiv prevention addressing sociocultural barriers prep access urgently needed failure weaken potential benefits biomedical prevention
deep convolutional neural networks cnns widely used obtain high level representation various computer vision tasks however field remote sensing sufficient images train useful deep cnn instead tend transfer successful pre trained deep cnns remote sensing tasks transferring process generalization power features pre trained deep cnns plays key role paper propose two promising architectures extract general features pre trained deep cnns remote scene classification two architectures suggest two directions improvement first pre trained deep cnns design linear pca network lpcanet synthesize spatial information remote sensing images spectral channel design shortens spatial distance target source datasets pre trained deep cnns second introduce quaternion algebra lpcanet shortens spectral distance remote sensing images images used pre train deep cnns five well known pre trained deep cnns experimental results three independent remote sensing datasets demonstrate proposed framework obtains state art results without fine tuning feature fusing paper also provides baseline transferring fresh pre trained deep cnns remote sensing tasks
known objectivesrituximab chimeric monoclonal anti antibody approved treatment lymphoid malignancies well autoimmune diseases including rheumatoid arthritis idiopathic thrombocytopenic purpura itp vasculitis generally rituximab well tolerated nevertheless patients develop adverse effects including infusion reactions albeit rare reactions may cases life threatening conditions rituximab cardiovascular side effects include common effects hypertension oedema rare cases arrhythmias myocardial infarction case summaryin article report case year old man history overlap syndrome including limited scleroderma treated rituximab developed dramatic elevation myocardial infarction stemi drug administration new conclusionthis report underlines previous published reports emphasizing awareness association communication also warrants importance screening ischaemic heart disease selected cases patients treated rituximab
introduction etiology irritable bowel syndrome ibs unknown several factors appear play role pathophysiology including abnormalities gastrointestinal endocrine cells present review illuminates possible role gastrointestinal hormones pathophysiology ibs possibility utilizing current knowledge treating disease areas covered research intestinal endocrine cells possible role pathophysiology ibs discussed furthermore mechanisms underlying abnormalities gastrointestinal endocrine cells ibs patients revealed expert commentary abnormalities observed gastrointestinal endocrine cells ibs patients explains visceral hypersensitivity gastrointestinal dysmotility abnormal intestinal secretion well interchangeability symptoms time clarifying role intestinal stem cells pathophysiology ibs may lead new treatment methods ibs
signaling pathways sustain disease process chronic rhinosinusitis nasal polyps crswnp remain poorly understood sought determine expression levels wnt signaling genes crswnp study role wnt pathway inflammation epithelial remodeling nasal mucosa microarrays real time quantitative polymerase chain reaction comparing gene expression matched nps inferior turbinates revealed wntb wnta wnt wnta wntb fzd regulated fzd lrp lrp wif regulated nps immunolabeling showed robust expression wnt ligands nuclear catenin axin tissue suggesting wnt beta catenin signaling activated nps used primary human nasal epithelial cell hnepc cultures test functional consequences wnt pathway activation monolayer hnepcs treated recombinant human wnt rhwnt rhwnt altered epithelial morphology decreased adhesion without loss viability found neither rhwnta rhwnt treatment induced proliferation expression release inflammatory cytokines granulocyte macrophage colony stimulating factor increased rhwnta exposure hnepcs differentiated air liquid interface rhwnta wnt agonist rhwnt treated hnepcs abnormal epithelial architecture failed undergo motile ciliogenesis defective noncanonical wnt planar cell polarity signaling basis results propose model wnt beta catenin signaling sustains mucosal inflammation leads spectrum changes consistent seen epithelial remodeling nps
purpose review review addresses salient articles field child maltreatment published goal helping general practitioner understand evolution research field child abuse pediatrics board certified specialty since recent findings researchers continue refine database child abuse pediatrics several articles focus inconsistencies approach evaluation possible physical child abuse hospitals practitioners multiple researchers aim develop protocol standardizes response findings sentinel injury rib fracture abdominal trauma unexplained bruising nonambulatory infant professionals also working improve understanding impact trauma children best ameliorate effects summary solid evidence based literature published various topics field child abuse pediatrics experts work refine unify clinician approach evaluation possible physical abuse
grid computing environment several classes multi component applications exist types applications may often require additional resources different types beyond available sites making grid resource composition heterogeneity nature user application computing environment makes challenging problem however current shelf scheduling software hardly cope diversities distributed computing application frameworks therefore need adequate scheduling system would grant simultaneous coordinated access application multi component nature requires resources possibly multiple types multiple locations managed different resource providers main focus paper develop mobile agent scheduling model addresses aforementioned challenge scheduling policy pertains job scheduling resource allocation proposed scheduling policy treats different multi component applications requiring diverse heterogeneous resources fairly policy used mobile agents schedule user applications also find available suitable distributed resource capable executing user application minimal time copyright john wiley sons ltd
objective study investigate risks associated use roof harvested rainwater rhrw implication pigeons likely source contamination testing antibiotic resistance profiles escherichia coli total coli isolated thirty fresh pigeon faecal samples isolates rhrwtanks three sites pretoria two johannesburg coli isolates tested panel antibiotics included ampicillin amoxicillin amikacin cefoxitin ceftriaxone chloramphenicol ciprofloxacin cotrimoxazole enrofloxacin gentamicin nalidixic acid tetracycline samples resistance ampicillin gentamicin amikacin tetracycline amoxicillin frequently encountered form resistance however relatively higher proportion isolates pigeon faeces antibiotic resistant rhrw highest number phenotypes observed single antibiotics single antibiotic resistance observed chloramphenicol ceftriaxone gentamicin cefoxitin cotrimoxazole although detected multiple antibiotic resistance mar phenotypes highest multiple antibiotic resistance mar phenotypes observed combination four antibiotics isolates jhb pigeon faeces pretoria abundant resistance phenotype four antibiotics cip dominated isolates pigeon faeces pretoria johannesburg isolates low proportions respectively future studies target isolates various environmental settings rainwater harvesting practiced characterisation antibiotic resistance determinant genes among isolates
order meet needs modern intelligent agricultural detection paper designs develops novel energy saving intelligent wireless agricultural detecting system combined technologies green power supply wireless transmission digital control system powered green energy resources solar energy wind power combined digital control wireless communication technologies achieve collection large amount parameters terms modern agricultural cultivation meet needs different application scenarios results repeated experiments shown advantages green environmentfriendly flexible reliable
type diabetes associated observational studies higher bone mineral density bmd higher fracture risk given bmd relationships may however confounded factors body mass index bmi used mendelian randomization obtain non confounded estimates effect glycemic traits bmd identified genetic variants strongly associated risk cases controls fasting glucose nondiabetic individuals associated bmi determined effects variants bmd individuals using variants instrumental variables found genetically increased risk increased femoral neck bmd bmd per unit increase log odds genetically increased fasting glucose also increased femoral neck bmd bmd per mmol increase fasting glucose similar nonsignificant trends observed effects fasting glucose lumbar spine bmd results indicate genetically increased risk genetically increased fasting glucose weak positive effects bmd american society bone mineral research
functional near infrared spectroscopy fnirs technique used noninvasive measurement oxyhemoglobin hbo deoxyhemoglobin hhb concentrations brain tissue since ratio concentration two agents correlated neuronal activity fnirs used monitoring quantifying cortical activity portability fnirs makes good candidate studies involving subject movement fnirs measurements however sensitive artifacts generated subject head motion makes fnirs signals less effective applications paper autoregressive moving average arma modeling fnirs signal proposed state space representation signal fed kalman filter estimating motionless signal motion corrupted signal results compared autoregressive model based approach done previously show arma models outperform models attribute richer structure containing terms indeed arma show signal noise ratio snr higher arma based method
frequent items high speed streaming data important many applications like network monitoring anomaly detecting deal high arrival rate streaming data desirable systems capable supporting high processing throughput tight guarantees errors paper address problem finding frequent top items present parallel version space saving algorithm context open source distributed computing system based theoretical analysis errors restrictively bounded algorithm parallel design could achieve high throughput taking advantage distributed computing resources evaluation reveals design delivers linear speedup remarkable scalability
present climatic scenario several factors expected affect clusterbean cyamopsis tetragonoloba taub yield parameters yield gum content also likely change crop production practices especially related crop sowing environment stress management experiment conducted kharif season objectives study investigate impact changing sowing environments adaptation strategy current climatic scenarios simulate effect bio regulators crop productivity paper investigates normal july late july sowing environments foliar spray thiourea ppm salicylic acid ppm days sowing amongst foliar spray significantly higher yield parameters yield gum content recorded foliar spray thiourea ppm compared bio regulators spray level similarly salicylic acid ppm found statistically par thiourea ppm foliar spray das
modern information network society data security important daily lives data encryption system help protect security personal information paper mainly introduces hardware software design lower computer data encryption system involving communication interface design memorizer design circuit design algorithm selection algorithm design system testing high success rates encryption decryption improves programming speed
paper architecture smart school laboratory proposed based technologies smart environment multi agent systems employed improve comfort effectiveness safety conducting laboratory work technological equipment computers machine tools
paper describes use smart materials adaptronic control concepts small size robots small size specific research means robot hand span several centimeters tens centimeters possibility building robot mechanics using different kind smart materials analyzed target build specific robot possible solutions analyzed control method sma shape memory alloy actuator proposed method estimating temperature inside sma sample described experimental setup built test measurements made dynamics control energy consumption proposed control method analyzed
theoretical experimental analysis modified version sepic converter used preregulator operating discontinuous conduction mode dcm presented paper proposed converter presents low input current ripple operating dcm switch voltage lower output voltage switch voltage reduction increases converter reliability low drain source resistance rdson mosfet used depending converter specification moreover digital control technique applied proposed converter order reduce third harmonic input current distortion resultant operation dcm finally prototype developed operating efficiency equal
piezoelectric single pole single throw spst switch developed since satisfying commercial low resistance high current contact switch available operable high magnetic field least piezoelectric switch shows low insertion loss less within bandwidth mhz operated switch could also used mechanically disconnect connect electrodes electrical circuits one another elsevier rights reserved
leading meetings represent typically frequently performed leadership task study investigated relationship leadership style supervisors employees perception meeting outcomes results showed participants reported greater meeting satisfaction meeting leader assessed considerate supervisor relationship considerate leadership style meeting satisfaction mediated relational task oriented meeting procedures results however provide support initiating structure associated meeting effectiveness measures generally findings imply leadership behavior crucial factor explaining important meeting outcomes
one main effects endocannabinoid system brain stress adaptation presynaptic endocannabinoid receptor receptors playing major role present study investigated whether effect receptor coding cnr gene migraine symptoms conditional life stress cross sectional european population recruited manchester budapest used migraine questionnaire migraine screening life threatening experiences questionnaire measure recent negative life events rle covered cnr gene snps main genetic effects cnrxrle interaction age sex covariates tested none snps showed main genetic effects possible migraine symptoms snps showed nominally significant interaction rle headache nausea using logistic regression models effect remained significant correction multiple testing replicated subpopulations effect independent depression anxiety related phenotypes addition bayesian systems based analysis demonstrated development headache nausea snps relevant higher posteriori probability experienced recent life stress summary cnr gene interaction life stress increased risk headache nausea suggesting specific pathological mechanism develop migraine indicating subgroup migraine patients suffer life stress triggered migraine frequent nausea may benefit therapies increase endocannabinoid tone
optimal hemodynamics aorta pulmonary shunt reconstruction essential improved postoperative recovery newborn congenital heart disease patient however prior vivo execution prediction post operative hemodynamics extremely challenging due interplay multiple confounding physiological factors hypothesized post operative performance surgical shunt predicted computational blood flow simulations consider patient size shunt configuration cardiac output complex three dimensional disease anatomy utilizing routine patient specific pre surgery clinical data sets demonstrated intelligent decision making process real patient pulmonary artery atresia ventricular septal defect patient total customized candidate shunt configurations contemplated reconstructed virtually using sketch based computer aided anatomical editing tool candidate shunt configurations evaluated based parameters computed flow simulations include flow complexity outlet flow splits shunt patency coronary perfusion energy loss results showed modified blalock taussig mbt shunt higher right pulmonary artery rpa lower left pulmonary artery lpa flow compared central shunt configuration also rpa flow regime distinct lpa creating uneven flow split pulmonary arteries three shunt sizes right mbt innominate central configurations cause higher pulmonary artery flow lower coronary artery pressure right left mbt subclavian configurations trade energy loss flow split coronary artery pressure overall mbt shunts provide sufficient perfusion higher coronary artery pressures could preferred similar patients overflow risk central shunts would preferred otherwise particularly cases low overflow risk elsevier ltd rights reserved
procedure reuse finite element method fem programs heat transfer structure analysis solve advanced thermo mechanical problems presented powerful algorithm applicable coupling physical fields magnetic fluid flow etc case nonlinear block gauss seidel partitioned algorithm strongly couples heat transfer structural fem programs component based software engineering component template library provides possibility exchange data components solve corresponding subproblems structural component evaluates dissipative energy induced inelastic strain heat transfer component computes temperature change due dissipation convergence guaranteed posing global convergence criterion previously locally converged coupled variables enables reuse software allows numerical simulation thermo sensitive problems
improve energy utilization efficiency solar energy tio peg sio form stable phase change material pcm characters light heat conversion thermal conductivity enhancement developed situ doping titanium black tio acid alkali catalytic sol gel method structure properties pcm investigated sem xrd dsc coefficient thermal conductivity thermal conversion testing etc results showed tio peg sio could effectively absorb visible light solar radiation simultaneously light energy translated thermal energy storied pcm furthermore composite pcm exhibited good thermal stability degrees excellent shape stabilized effect high thermal conductivity tio peg sio novel thermal storage material usefully enhance utilization efficiency solar energy
ambient intelligence vision future environments support people living environment self effacing interconnected adaptable dynamic embedded intelligent vision disappear technology instead processors sensors integrated everyday objects develop environment wherein technology invisible user environment directly communicates user completely interactive environment could assists users every possible manner order design develop environment need shift technology machine human communication machine machine communication communication requirement real time data energy decision making concepts considered main objectives needs fulfilled paper present major contribution various researchers field also discussed major challenges risks associated intelligent environment methodology overcome challenges ami environment
paper mhz spurious free dynamic range sfdr cmos variable gain amplifier vga presented digital tuner applications proposed rfvga adopts wideband operational amplifier based vga wideband buffer differential multiple gated transistor linearization method wideband operation high linearity sfdr proposed rfvga also analyzed detail fabricated cmos process rfvga provides gain range gain step minimum noise figure maximum gain maximum band output referred third order intercept point dbm drawing average current supply voltage chip core area mmx copyright john wiley sons ltd
streams urban areas prone degradation urbanization induced poor water quality widely observed well documented phenomenon mechanism pinpoint local drivers urban stream degradation relative influence water quality still lacking utilizing data citizen science project freshwater watch use machine learning approach identify key indicators potential drivers potential controls water quality across metropolitan areas shanghai guangzhou hong kong partial dependencies examined establish direction relationships predictors water quality random forest classification model indicated predictors stream water colour drivers related artificial land coverage agricultural land use coverage potential controls related presence bankside vegetation found important identifying basins degraded water quality conditions based individual measurements turbidity nutrient concentrations elsevier rights reserved
background antiphospholipid antibodies apls namely anticardiolipin acl antibody anti beta glycoprotein beta gpi antibody lupus anticoagulant autoantibodies produced anionic phospholipids proteins plasma membranes migraine primary headache disorder growing evidences autoimmune mediated pathogenesis previous studies suggested presence apls migraine patients aims aim study evaluate comorbid association apls acl anti beta gpi migraine compared healthy controls methods studies searched pubmed isi web science google scholar databases without restricting languages year october selected based inclusion criteria two authors independently extracted data included studies analyses conducted using random effects model calculate odds ratio confidence interval quality assessment carried using themodified newcastle ottawa scale nos publication bias evaluated via visualization funnel plots begg egger tests results database searches produced articles selected migraineurs healthy controls migraineurs exhibited acl anti beta gpi times higher respectively healthy controls significant presence acl anti beta gpi antibodies observed migraine patients however significantly associated majority studies demonstrated nos score significant publication biaswas observed conclusion migraine might autoimmune associated neurologic disorder presence acl anti beta gpi antibodies significant migraine patients compared healthy controls suggesting involvement autoantibodies migraine attack elsevier rights reserved
background patients chronic illnesses often required take lifelong medication alleviate symptoms prevent disease progression many patients find difficult adhere prescribed medication various reasons may link way conceptualise medicines understand illness treatment study explores medicine taking behaviours patients presenting rheumatoid arthritis chronic inflammatory autoimmune disease focused particularly patients conceptualisation understanding medicines within disease context backdrop scarce healthcare resources methods conducted semi structured interviews female patients rheumatology clinic south africa well review participants medical records conducted secondary analysis data using thematic analysis framework analysis principles results participants reported range medicine taking behaviours including self medicating adding complementary alternative medicines cam traditional remedies sometimes acquiring prescribed medicines illegally participants provided insights understanding constitutes medicine substances added prescribed regimen impacted adherence importantly majority participants demonstrated poor understanding illness medications regimens dosage instructions conclusions medicine taking context within studied demographic complex appears strongly mediated individual contextual factors poor patient understanding individual conceptualisation medicines medicine taking availability range additional medicines remedies impact adherence based findings make suggestions healthcare providers play greater role educating patients living medicines cam traditional remedies well medicine taking behaviours
low birth weight vlbw neonates commonly experience acute kidney injury aki neonatal intensive care unit nicu hypothesize vlbw neonates exposed aki nicu might higher risk renal dysfunction childhood cohort study vlbw children aged years completed kidney health evaluation stratified according aki status nicu primary outcome renal dysfunction defined following estimated glomerular filtration rate egfr blood pressure aeth percentile thirty four subjects completed study twenty subjects history neonatal aki stage stage stage median age years aki group higher risk renal dysfunction compared group without aki relative risk overall total cohort egfr min using serum cystatin aki subjects aki subjects evidence renal dysfunction neonates born vlbw found early childhood work necessary determine reduce renal disease vulnerable population
background psoriatic arthritis associated psychosocial morbidity decrease quality life psychiatric comorbidity also plays important role impairment quality life onset fatigue objectives study aimed assess prevalence fatigue psoriatic arthritis patients correlate quality life indexes functional capacity anxiety depression disease activity patients methods cross sectional study performed outpatients psoriatic arthritis functional assessment chronic illness therapy fatigue facit version used measure fatigue item short form health survey psoriasis disability index pdi measure quality life health assessment questionnaire haq assess functional capacity hospital anxiety depression scale measure anxiety depression symptoms psoriasis area severity index pasi bath ankylosing spondylitis disease activity index basdai clinical disease activity index cdai evaluate clinical activity results patients mean age years included mean pdi score pasi score basdai score haq score anxiety score depression score facit fatigue scale facit score cdai score facit statistically associated pasi pdi haq correlations cdai basdai confirmed statistically significant correlation domains facit version conclusion prevalence fatigue moderate intense patients psoriatic arthritis fatigue seems related emotional social aspects disease joint inflammatory aspects confirming disease visibility disturbing aspect patient skin pain intense joint pain
damage localization algorithm based operational deformed shapes known interpolation damage detection method herein applied finite element model cable stayed bridge detecting localizing damages stays supporting steel beams bridge deck frequency response functions calculated basing responses bridge model low intensity seismic excitations used recover operational deformed shapes transversal vertical direction analyses carried undamaged configuration repeated several different damaged configurations results show method able detect damage correct location provided accurate estimation operational deformed shapes available furthermore damage detection algorithm results effective also damages coexist time several location cable stayed bridge members
since european space agency investigated file based system providing satellite radio automotive market system significantly different existing commercial counterparts american systems radio sirius terms service provides traditional radio services also capable offering multimedia content data transfer terms infrastructure require launch new satellites deployment terrestrial repeaters offers highly efficient low investment low risk approach offering satellite radio services consumer automotive market moreover departs traditional schedule based streaming radio concept concept line concurrent developments within media landscape providing user full control entertainment play play paper presents system detail outlines performance makes comparisons existing satellite radio systems copyright john wiley sons ltd
background antisocial narcissistic schizotypal personality disorders share dissocial traits different impairments recognizing facial emotions whether differences due early perceptual late cognitive cerebral processes remains unknown methods invited patients antisocial narcissistic schizotypal personality disorder healthy volunteers undergo cerebral event related potentials facial expressions neutral anger happiness sadness anxiety depression measures results compared healthy volunteers reaction time happiness prolonged people narcissistic personality disorder amplitude sadness smaller people antisocial personality disorder amplitudes neutral happiness negatively correlated depression people narcissistic personality disorder latencies happiness delayed people schizotypal personality disorder relative healthy volunteers conclusions responding facial emotions attention cerebral process shallow antisocial emotionally affected narcissistic time expanded schizotypal patients elsevier ltd rights reserved
traditional junction solar cells imbedded quantum dots attractive achieve chromatic light absorption enhancement paper multi layer stacked gaas quantum dots grown droplet epitaxy technique sandwiched layers solar energy harvesting performance gaas ingaas quantum dot solar cells compared using structural optical electrical measurements two step photon absorption process studied via adding external infrared pumping sources quantum efficiency measurements room temperature work demonstrates strain free nanostructures droplet epitaxy promising photovoltaic application
aberrant expression mir frequently reported cancers excluding lung cancer role molecular mechanism mir lung cancer reported study explored effects mir overexpression apoptosis invasion lung cancer cells mrna level mir non small cell lung cancer nsclc lines determined real time pcr mir mimic transiently transfected lung cancer cells using lipofectamine reagent subsequently brdu elisa results showed introduction mir inhibited cell proliferation addition mir overexpression could also inhibit emt cells qrt pcr used determined expressions matrix metalloproteinase mmp lung cancer cells next found kappa expression evidently reduced regulation mir bioinformatics analysis predicted kappa potential target gene mir luciferase reporter assay confirmed mir could directly target utr kappa conclusion mira suppresses proliferation metastasis lung cancer cells regulation kappa overexpression mir might potential therapeutic strategy treatment lung cancer future
tumor normal cell interplay defines course neoplastic malignancy outcome dual relation ultimate prevailing one cells death retreat paper study mathematical principles underlay one important scenario slow progressing cancers develop within stochastic framework mathematical model account tumor normal cell interaction clinically relevant situation derive number deterministic approximations stochastic model consider detail existence uniqueness solutions deterministic model study stability analysis focus model specific case low grade gliomas introduce optimal control problem different objective functionals administration chemotherapy derive conditions singular bang bang control exist calculate optimal control states elsevier rights reserved
objective increasing recognition socio cognitive skills moral reasoning affected wide range developmental neuropsychological conditions however lack appropriate measures available neuropsychologists poses challenge direct assessment skills study sought explore age related changes using innovative visual tool examine developmental sensitivity task method address methodological limitations traditional measures novel visual task socio moral reasoning aptitude level moral used evaluate healthy participants aged years results findings show linear increase childhood late adolescence significant group differences childhood years preadolescence years early adolescence years middle adolescence years conclusions interpreted light current brain development research results highlight age related changes offer insight typical development opportunities comparisons clinical populations findings also provide evidence potential moral developmentally appropriate measure throughout childhood adolescence
longitudinal studies japan indicate nocturnal sleep onset become later sleep duration progressively shortened study aimed investigate relationship sleep patterns sleep problems among children determine association parents children sleep habits questionnaires sleep problems life habits administered families living tokyo metropolitan areas japan analyzed data pre school age years old including girls elementary school age children years including girls well parents mothers years fathers years subjects categorized morning evening type answered lifestyle habit definitely moderately morning evening type sleep categorized regular irregular intermediate sleeping waking regularity scores frequency daytime dozing significantly high children evening irregular sleep moreover mothers children aged years evening irregular sleep significantly irregular sleep habits children morning regular sleep likewise fathers children aged years evening irregular sleep significantly irregular sleep habits thus irregular late bedtime parents associated sleep problems daytime sleepiness irregular dietary habits children mothers sleep habits stronger influence children sleep fathers study indicates importance promoting sleep hygiene encourages healthy sleep family members
assess value cardiac magnetic resonance imaging cmr evaluating cardiac tumours tertiary cardiology centre patients pts total received cmr examination institution referred suspicion cardiac tumours dedicated protocol used included standard cine ssfp acquisitions well tissue characterization using black blood respectively without fat suppression perfusion structure late gadolinium enhancement patients files retrospectively analysed data related clinical status results examinations echocardiography therapeutic approach histology results performed collected pts diagnosis cardiac tumour reached pts biopsy cmr examination concordant histology results pts superior showed echocardiography pts forty two pts benign tumour malignant process myxoma frequent benign tumour cardiac metastases frequent form malignancies cell non hodgkin lymphoma frequent one benign tumours mostly located left atrium versus whereas malignant tumours predilection right atrium und left ventricle benign cardiac tumours single show signs infiltration conversely malignant cardiac tumours larger significant proportion showing myocardial infiltration pts malignant cardiac tumours higher proportion lge exhibited frequently isointense signal images groups showed similar proportion perfusion signal intensity acquisitions cmr valuable tool evaluating cardiac tumours proving superior echocardiography establishing type cardiac tumour
phytochemical investigation stem bark xylopia pierrei hance led isolation one triterpene polycarpol three heptenes acetylmelodorinol melodorinol melodienone four flavonoids pinocembrin isochamanetin chrysin dichamanetin compounds isolated first time plant species structures isolated compounds characterized spectroscopic techniques comparison spectroscopic data literature values stereochemistry asymmetric carbon determined modified mosher method among compound displayed potent cytotoxic activity human small cell lung cancer nci cells value fold higher reference anticancer drug ellipticine addition compound also evaluated non cancerous vero cells showed high selectivity index fold greater ellipticine findings suggest compound developed potential lead molecule anticancer drug development
objectivesto assess skeletal status asthmatic children treated inhaled corticosteroids longitudinal observation quantitative ultrasound measurement hand phalanges methodsthirty four children studied prospectively quantitative measurements performed baseline meansd years obtained results compared age sex body size matched control participants selected database previously examined healthy children individual changes amplitude dependent speed sound sos follow period also analyzed resultsthe mean age asthmatic children years mean sos asthmatic children baseline mean score corresponding values follow examination results differ significantly comparison healthy controls analysis individual changes sos revealed participants significant increase parameter exceeding least significant change threshold significant change values one significant decrease sos conclusionsquantitative hand phalanges applied diagnostic tool revealed essential differences pattern skeletal development asthmatic children treated inhaled glucocorticosteroids healthy controls
past years women participation workforce athletics professional education increased men activities stable gender stereotypes changed time period reflect new realities extent gender stereotyping exist today address questions comparing data collected early new data collected study participants rated likelihood typical man woman set gendered characteristics traits role behaviors occupations physical characteristics results indicate people perceive strong differences men women stereotype components today past comparisons two time periods show stability gender stereotypes across components except female gender roles showed significant increase gender stereotyping results attest durability basic stereotypes men women perceived differ despite changes participation acceptance women men nontraditional domains gender stereotypes apparently deeply embedded society position evaluate women men well women men need constantly vigilant possible influence stereotypes judgments choices actions online slides instructors want use article teaching available pwq website http pwq sagepub com supplemental
relevant biochemicals brain quantified vivo non invasively using proton magnetic resonance spectroscopy mrs includes metabolites associated neural general functioning energetics membrane phospholipid metabolism neurotransmission moreover substantial evidence implication frontal prefrontal areas pathogenesis psychotic disorders schizophrenia particular anterior cingulate cortex acc plays important role cognitive control emotional non emotional processes thus study extent biochemistry dysfunction early stages psychosis particular interest gaining greater understanding aetiology review selected mrs studies focused acc first episode psychosis fep four studies reported increased glutamatergic levels fep four showed preserved concentrations moreover findings fep fully mirror chronic patients due conflicting findings larger longitudinal mrs studies expected explore glutamatergic neurotransmission acc fep order better understanding glutamatergic mechanisms underlying psychosis possibly using ultra high field scanners
recent years practice adding game design non game services gained relatively large amount attention popular discussion connects gamification increased user engagement service profitability goal commitment overall betterment various behavioral outcomes however still absence coherent ample body empirical evidence would confirm expectations end paper reports results year year group field experiment gamifying service implementing game mechanic called badges experiment pre implementation group monitored year implementation post implementation gamified condition group monitored another full year results show users gamified condition significantly likely post trade proposals carry transactions comment proposals generally use service active way elsevier ltd rights reserved
extant studies indicate persons autism difficulties social interaction verbal nonverbal communication repetitive behaviors poor ability generalize learned skills obesity also identified significantly affecting children autism spectrum disorders asd negative experience physical education may antecedent behavior lack activities mediators sedentary lifestyles contributors chronic illnesses associated overweight obesity students asd often perform required activities meet required standards imperative school nurses aware many challenges students asd bring class school nurses provide education members school community including individualized education plan team regarding need attention limitations including physical activity students asd
diversity training challenging evoke strong emotional responses participants including resistance shame confusion powerlessness defensiveness anger responses create complex situations presenters learners observed experienced presenters implemented gender bias literacy workshops faculty stemm science technology engineering mathematics medicine departments one midwestern university recorded questions answers well participants non verbal activity hour workshop employing content analysis critical incident technique identified content elicited heightened activity challenging dialogues among presenters faculty results analysis observational data found three important findings presenters continually reinforced idea implicit bias ordinary pervasive thus avoiding participant alienation allowing participants protect self worth integrity difficult dialogues managed calmly without verbal sparring relinquishing control presenters created environment individuals likely accept threatening information
social learning important process spread information especially changing environments inherited behaviors may remain relevant many species decision trust reliable information depends relationship individuals many fish species including three spined sticklebacks preferentially associate familiar individuals previous studies three spined sticklebacks provided mixed evidence effect familiarity social learning species therefore study explores familiarity social learning sticklebacks specifically demonstrator focused perspective found food patch discrimination task individuals unfamiliar demonstrators performed significantly better familiar demonstrators problem solving task found focal fish attended behavior demonstrators detect effect familiarity performance indeed proportion individuals solve task observing demonstrators low results suggest sticklebacks preference unfamiliar demonstrators use social information varies depending context
paper presents efficient numerical methodology obtain frequency response switched capacitor filters based circuits differential equations methodology uses non hierarchical approach non ideal effects transistors switches amplifier taken consideration allowing accurate computation frequency response even case incomplete settling branches accuracy demonstrated comparing results obtained using proposed methodology obtained using transient electrical simulation results three different circuits first order passive filter second order lowpass filter second order bandpass filter showing results good agreement time consuming electrical simulation circuits
background intracerebral cladophialophora bantiana may carry mortality rate despite advances surgical resection capabilities use systemic intrathecal antifungal treatments objectives authors examined retrospective case series two patients intracerebral infection rare neurotropic fungus cladophialophora bantiana conducted literature review evaluate optimal therapies patients methods institution patients cases presented raised intracranial features headache visual field cut memory loss correspondingly wide variety radiological differential diagnoses microbiological histopathological genomic identification bantiana ensured targeted individualized patient therapies results conclusions successful treatment depends obtaining complete surgical resection accurate microbiological diagnoses mold identification effective long term personalized antifungal treatment close radiographic surveillance necessary ensure complete eradication pheoid fungi
background antibodies saccharomyces cerevisiae asca antibodies perinuclear anti neutrophil cytoplasmic panca pancreatic autoantibodies pab antibodies intestinal goblet cells gab important diagnosing crohn disease ulcerative colitis however little known diagnostic value real clinical practice china retrospective study aimed present year clinical experience biomarkers diagnosis methods total patients patients patients intestinal associated diseases disease controls included serum asca determined elisa serum panca gab pab tested indirect immunofluorescent assay retrospective review laboratory results clinical information performed results asca asca panca showed poor abilities differentiating intestinal behcet disease intestinal tuberculosis itb contrast pab exhibited good capacities differentiating intestinal itb igg panca demonstrated high sensitivity specificity differentiating panca asca panca pab displayed high sensitivity specificity differentiating gab showed poor potential differentiating pab positively correlated early disease onset ileocolonic disease perianal disease patients conclusions data suggest panca pab helpful diagnosis respectively asca gab findings indicate clear need additional biomarkers diagnosis china
knee point curve permanent magnet considered crucial electric motor applications case severe fault conditions overheating short circuit electric motors working point might fall knee point causing irreversible demagnetization hence remanence flux decreases motor operation would reduced stalled paper two demagnetization models pms investigated linear model exponential model demagnetization curves ndfeb measured temperatures varying room temperature degrees found parameters exponential model including fitting parameter temperature dependent therefore exponential model developed function temperature allows efficient implementation within electric motor applications using pms however comparison exponential linear models indicates latter better accuracy near knee point demagnetization curves ndfeb magnets
chronic systemic inflammation csi recently identified major contributor common diseases ranging cancer metabolic disorders neurologic alterations last decade others generated genetically engineered mouse models inflammatory diseases enable studying molecular mechanisms csi recently organ cross talk induced csi homeostatic pathological conditions begun appreciated review revisit whole organism physiology relation csi originating epithelial tissues skin gut furthermore discuss current knowledge regarding mechanisms specific immune cells molecules responsible inducing common comorbidities cardiovascular metabolic neurological complications well bone loss heterogeneous diseases like psoriasis atopic dermatitis inflammatory bowel disease would impossible discuss comorbidities diseases well epithelial tissues present overview special emphasis recent findings linking skin inflammation bone loss
article discusses design unmanned aerial vehicle whose purpose study use electric ducted fans control propulsion system thrust vectoring essential stabilizing vehicle present measurement results characterizing thrust vectoring capabilities propulsion system statically dynamically discuss first principle model describing behavior flying machine analyze quantify controllability hover first principle model subsequently used cascaded control design shown work reliably practice furthermore system identification results discussed used extended model resulting augmented model shown match measured frequency response function elsevier ltd rights reserved
fibulin extracellular matrix ecm protein implicated connective tissue development elastic fiber formation however little known underlying function fibulin cartilage development aim study investigate role probable mechanism fibulin stimulation ecm production chondrocyte differentiation fibulin observed abnormally elevated matrix metalloproteinases mmp level highly expressed human osteoarthritis chondrocytes chondrogenic cell line atdc fibulin stimulation profoundly inhibited expression ecm gene type collagen cola aggrecan acan type collagen cola expression fibulin attenuated expression master transcription factors sox sox runx effect expression sox additionally fibulin stimulation activated canonical wnt pathway reducing expression writ inhibitor dkk sost moreover fibulin augmented expression wnt beta catenin signaling target genes like beta catenin wnt well diminished gsk beta activation dkk abolished effect fibulin chondrocyte differentiation suggesting fibulin important regulator ecm production chondrocyte differentiation dkk mediated wnt beta catenin signaling study provides evidence previously unknown link fibulin canonical wnt beta catenin pathway may contribute understanding molecular mechanisms elsevier rights reserved
objective evaluate patients fluctuation self reported disease activity basdai patient global well visual analogue scale vas global spinal pain vas pain years follow group level clinical relevance fluctuations patient level methods dutch patients outcome international study cohort completed patient reported outcome measures every months years group level mixed linear models used analyse whether outcome measures constant time patient level relevant changes scores assessed frequency changes would exceed predefined cut values scale years follow using month assessments results ninety patients median age years male symptom duration years included group level outcome measures remained constant time however large fluctuations found patient level example using month intervals patients least one change respectively basdai year follow prolonging interval proportion changes exceeding cut decreased indicating information lost similar results found vas global vas pain conclusion substantial fluctuations basdai vas global vas pain found individuals time longer intervals fewer fluctuations observed indicating relevant changes might missed
aim work propose methodology seeks discover increased performance algorithms configuration parameters influence finally discover using statistical methods settings virtual environment achieve best results average experimental design preestablished set tests using scientific statistical criteria mainly order determine influence various factors results metric system process identifying observing reasons led change expected value planning used factorial planning factor core memory operating system virtual machine varied three levels tested operating systems ubuntu bit centos bit windows bit virtual machines tested kvm xen vmware data collected analyzed using analysis variance results show major analyzed factors changes algorithm performance analyzed separately also significant interactions belonging factors significance level analysis variance showed core interactions memory memory memory factors impact runtime analyzed algorithm
redundant system collocated geodetic sensors accelerometer used measure displacements stiff long footbridge excited essentially vertical synchronized jumps main output measurements excitations produced vertical deflections order several lateral deflections amplitude half vertical effect known various bridges also smaller scale longitudinal deflections probably induced vertical ones combination deflections three axes artifact measuring errors limitations specific instruments reflect random effects observed different experiments different sensors global navigation satellite system gnss global positioning system gps plus russian global navigation satellite system glonass robotic total stations rts robotic theodolite accelerometer tested control measurement errors time series reflecting bridge oscillations cases sensors provided similar estimates deflections deflection derived dominant frequencies found equal derived accelerometer proposed instrumentation methodology seem suitable control deflections bridges cases visibility satellites poor disrupted vehicle circulation measurement based modeling bridges described might useful understanding structural behavior bridges several types dynamic loads contribute displacement based design structures copyright john wiley sons ltd
rugby union rugby participants higher average risk injury compared participants popular team sports boksmart nationwide injury prevention program launched south africa mid goal reducing catastrophic head neck serious injuries players program provides injury prevention information coaches referees study investigated boksmart associated reduction injuries boksmart program collected data south african rugby related serious injuries since using poisson regression injury numbers compared pre boksmart years post implementation player numbers assumed constant throughout evaluation junior senior junior players post boksmart period less annual serious injuries pre boksmart incidence rate ratio confidence interval contrast significant difference periods seniors absence effect seniors may result fewer players differences effectiveness boksmart group future studies investigate questions
computer systems designed help solve problems presented society new terms computational sustainability internet things present new fields traditional information systems applied implemented environment maximize data output ability understand improve advancement richer interconnected devices created opportunities gather new data sources environment use together pre existent information new reasoning processes work describes sensorial platform designed help raise awareness towards sustainability energy efficient systems exploring concepts ambient intelligence fusion data create monitoring assessment systems presented platform embodies effort raise awareness user actions impact towards sustainability objectives
paper evaluates usability information modelling tools common operating systems windows linux mac osx stages bim maturity availability building information modelling tools vary dramatically platforms paper compares current software tools used building process list attributes mature software platform accommodate created evaluation criteria determined specific needs various participants building process leads successful project completion subsequent management lifecycle building authors published elsevier ltd
incompressible fluids current interest considering dimensional variable coefficient boiti leon manna pempinelli model incompressible fluid perform symbolic computation work variable coefficient dependent auto backlund transformation along two variable coefficient dependent classes shock wave type solutions auto backlund transformation different recently reported bilinear one
self memory system encompasses working self autobiographical memory episodic memory specific autobiographical memories patterns activation knowledge structures autobiographical episodic memory brought activating effect cues working self elaborate cues based knowledge initially activate control construction memories past future proposed construction takes place remembering imagining system window highly accessible recent memories simulations near future events malfunctions various disorders considered implication term modern view human memory notions memory accuracy show memories degree false main role memories lies generating personal meanings published elsevier inc
medical image provide valuable information preclinical research clinical diagnosis treatment widespread use digital medical imaging many researchers currently developing medical image processing algorithms systems order accommodate better result clinical community including accurate clinical parameters processed images original images paper propose web based platform present process medical images using internet novel database technologies authorized users easily access medical images facilitate workflows processing server side powerful computing performance without installation implement series algorithms image processing visualization initial version rayplus integration system allows much flexibility convenience research clinical communities
given preponderance evidence supporting efficacy cognitive behavior therapy cbt increased emphasis dissemination community mental health systems cmh trainers two large scale dissemination initiatives surveyed regarding common pitfalls difficulties encountered cmh clinicians learning cbt common pitfalls organized according items cognitive therapy rating scale ctrs young beck reviewed guided discovery reported challenging cbt competency learn qualitative methods used construct grounded theory trainer responses indicated viewed practice cbt set discrete skills also way thinking efforts may needed provide support assistance resources cmh clinicians continue build cbt competency
light weight engineering composite technologies key strategies modem product development mechanical engineering well biomedical applications innovation driven novel material concepts surface functionalities designed customized surface properties advanced coating technologies important discipline context ceramic metallurgical cermet layers manufactured appropriate way high energetic thermokinetic deposition techniques like plasma spraying electric arc last least supersonic flame spraying hvof technologies perform high deposition rates high flexibility use various materials combinations applications micro macro scale products final properties coatings layer composites depend properties combined materials case ceramic coated light metals distinctly affected occurring residual stresses interaction operational load stresses respect complex geometries components dimensional positional tolerances strong influence robot kinematics plasma hvof torches coating manufacturing observed combining expertise materials manufacturing engineering coatings composites high performance reliability achieved shown development functionally coated cylinder liners crankcases ultra light weight engines well ceramic coated bioinert biodegradable substrates medical surgery shown cast engine block bores directly coated using automated hvof process obtaining improved coating results internal coating process hypersonic flame spraying superior technological alternative aps process high quality cylinder liner engine crankcase applications applications ceramic cermet coatings limited automotive biomedical applications wear friction properties biomedical compatibility used tailored thermophysical electrophysical catalytic properties various technical systems
potential impacts climate change food security subsistence farmers serious concern article explores food security situations two categories subsistence farm households vegetable cereal based farming systems makwanpur district nepal context climate change local climate data past years analyzed interviews local farmers key informants focus group discussions carried collect primary data empirical data showed changes climate variables study period line farmers perceptions farming communities negatively impacted perceived impacts erratic rainfall increased frequency floods droughts soil degradation insect pests weeds diseases farmers modified traditional cropping patterns calendar changed crop varieties increased fertilizer pesticide applications order maintain crop yields also sought farm employment however agricultural productivity area declining one third households area food secure household food insecurity mild moderate levels vegetable based households secure cereal based ones household level locally successful adaptive measures rainwater harvesting mulching planting date adjustments farm opportunities including infrastructure extension support could increase production contribute reversing impact increased risk attributed climate change
objectives diagnosis treatment thyroid diseases pregnant women remains challenge various medical associations recommend establishing reference intervals thyroid hormones local laboratory considering differences within geophysical socioeconomic conditions iodine prophylaxis various populations advisable assess reference intervals thyroid hormones specific region residence objective assess trimester specific reference intervals tsh pregnant women polish population methods results conducted prospective study centers representing different regions poland krakow warsaw poznan bialystok study included consecutive healthy pregnant women patients age range years women negative history thyroid diseases normal thyroid peroxidase antibody levels proper iodine prophylaxis newborns tsh levels appropriate reference range serum tsh thyroid peroxidase antibodies measured trimester reference intervals calculated using percentile method recommended international federation clinical chemistry reference values calculated miu tsh pmol pmol consecutive trimesters pregnancy reference intervals pregnant women compared general population showed lower concentration tsh every trimester pregnancy lower trimesters conclusions using appropriate trimester specific reference intervals may improve care pregnant women preventing misdiagnosis inadequate treatment european thyroid association published karger basel
fpga based accelerators recently evolved strong competitors traditional gpu based accelerators modern high performance computing systems offer high computational capabilities considerably lower energy consumption high level synthesis hls used overcome main hurdle mainstream usage fpga based accelerators complexity design flow hls enables designers program fpga directly using high level languages systemc opencl paper presents hls based fpga implementation several algorithms variety application domains performance comparison terms execution time energy power consumption high end gpus performed well algorithms modeled opencl gpu fpga implementation conclude fpgas much energy efficient gpus test cases considered moreover fpgas sometimes faster gpus using fpga specific opencl programming style utilizing variety appropriate hls directives
method visualize polytopes four dimensional euclidian space proposed polytope sliced multiple hyperplanes parallel separated uniform intervals since hyperplanes perpendicular axis resulting multiple slices appear three dimensional space shown standard computer graphics polytope rotated extrinsically four dimensional space means simple input method based keyboard typings multiple slices placed parabola curve three dimensional world coordinates slices view window form oval appearance simple double rotations four dimensional space applied polytope slices synchronously change shapes rotation applied polytope compact display oval many slices help quick rotations facilitate grasp four dimensional configuration polytope
grid rod fretting gtrf pressurized water reactors flow induced vibration phenomenon results wear fretting cladding material fuel rods gtrf responsible fuel failures pressurized water reactors united states predicting gtrf wear concomitant interval failures important large costs associated reactor shutdown replacement fuel rod assemblies gtrf induced wear process involves turbulent flow mechanical vibration tribology time varying irradiated material properties complex fuel assembly geometries paper presents new approach predicting gtrf induced fuel rod wear uses high resolution implicit large eddy simulation drive nonlinear transient dynamics computations gtrf fluid structure problem separated simulation turbulent flow field complex geometry fuel rod bundles using implicit large eddy simulation calculation statistics resulting fluctuating structural forces nonlinear transient dynamics analysis fuel rod ultimately methods developed used conjunction operational management improve reactor core designs fuel rod failures minimized potentially eliminated robustness behavior structural forces computed turbulent flow simulations results transient dynamics analyses highlight progress made towards achieving predictive simulation capability gtrf problem elsevier inc rights reserved
cable strong nonlinear characteristics static dynamic force frequency ratio boundary excitation meet conditions cable force perform vibration amplitude much initial value sling long span suspension bridge may perform parametric vibration vibration ratio vibrating bridge deck paper problem considering first order modal build parametric modal sling bridge deck boundary vibration considering coupling effect sling main girder deduced parametric vibration differential equation set considering sling damping coupling effect sling main girder
work combines photoplethysmographic electrical impedance plethysmographic measurements lack blood delivery oxygenation pregnancy may fatal consequences fetus photoplethysmographic measurements illuminate tissue measure change light absorption contribution photoplethysmographic measurement system presented hardware concept includes analog signal processing circuit photodiode special driver circuit power two light sources red infrared led photoplethysmographic measurements one led required view future purposes pulse oximetry second led already implemented furthermore paper shows results electrical impedance plethysmography designed photoplethysmographic measuring combination impedance cardiography might promising examine fetus
background genetic variants ige mediated peanut allergy yet fully characterized date one genomewide association study gwas published objective identify genetic variants associated challenge proven peanut allergy methods carried gwas comparing infants challenge proven ige mediated peanut allergy non allergic infants similar year old tested total million single nucleotide polymorphisms well imputed hla alleles amino acids replication assessed novo genotyping panel additional cases controls silico testing two independent gwas cohorts results identified independent associations unable replicate significant hla association previously reported amino acid variant located position within peptide binding groove hla drb study therefore reproduced previous findings association peanut allergy hla drb australian population conclusions clinical relevance genetic determinants challenge proven peanut allergy include alleles hla drb locus
many operations need performed modern finite element codes described operation needs done independently every cell followed reduction local results global data structure example matrix assembly estimating discretization errors converting nodal values data structures output visualization file formats fall class operations using realization identify software design pattern call workstream used model operations enables use multicore shared memory parallel processing also describe detail design pattern efficiently implemented provide numerical scalability results use deal software library
based transcritical rankine cycle ctrc promising technology waste heat recovery engine considering safety environment friendly characteristics also matchs high temperature exhaust gas satisfies miniaturization demand recovery systems traditional ctrc system basic configuration ctrc poor thermodynamic performance paper introduces improved ctrc system containing preheater regenerator ctrc recovering waste heat exhaust gas engine coolant engine compares performance ctrc system also traditional excellent organic rankine cycle orc systems using working fluid utilization rate waste heat total cooling load net power output thermal efficiency exergy loss exergy efficiency component size investigated results show net power output ctrc could reach engine increases compared ctrc ctrc also improves thermal efficiency exergy efficiency ctrc increases respectively compared orc system ctrc shows significant advantage highly recycling exhaust gas engine coolant simultaneously due special property supercritical specific heat capacity supercritical property also generates better heat transfer flowing performances meanwhile ctrc possesses smaller systems therefore ctrc system suitable waste heat recovery engine especially recovering high grade low grade waste heat elsevier ltd rights reserved
objective effect delirium stroke outcome quantified sub saharan africa investigated prevalence delirium occurring within one week stroke nigerian survivors association dementia mortality months methods delirium ascertained repeated assessments within one week stroke using confusion assessment method demographic clinical characteristics stroke severity current pre morbid cognitive functioning also assessed participants followed months using culturally validated neuropsychological tools probable dementia ascertained according national institute neurological disorders stroke ninds airen criteria associations investigated using binomial multinomial logistic regression analyses presented odds ratios relative risk ratios rrr results consenting stroke survivors two assessments delirium within one week stroke delirium present stroke survivors hypoactive hyperactive mixed type severe stroke associated delirium adjusting age gender education economic status lifestyle factors multimorbidities laterality follow severe stroke stronger association delirium dementia rrr death rrr conclusion delirium sub saharan african sample already present one third survivors within one week stroke survivors severe stroke higher risk delirium complications could important target delirium preventive interventions elsevier rights reserved
green buildings design construction evaluating sustainable effects site location transportation ecosystem human life critical difficult task works regarding matters require experience time labor manual calculations recent years many studies conducted enhance application building information modeling bim green building certifications however application bim site location transportation analysis usually considered impractical due lack powerful map application present bim products aim research develop framework integration bim web map service wms technologies location transportation analysis green building certifications using autodesk revit api google maps api development tools research converts integration model bim integrated plugin autodesk revit plugin used streamline certification process site location transportation analysis leed leadership energy environmental design one popular globally recognized green building standards elsevier rights reserved
early diagnosis dementia allows people access effective treatment make advance decisions still capacity aimed encourage people attend memory clinic order boost rates diagnosis created patient information video oxford health nhs foundation trust memory clinics inform empower awaiting assessment promote early diagnosis fourteen people patients carers staff approached prior developing video ascertain views themes video cover video consisted unscripted interviews patients carers staff surveyed participants new patients attending memory clinic get feedback video assess patients level understanding confidence memory assessment watching video video content refined based feedback final version produced patient feedback demonstrated confidence understanding increased watching video although study limited small sample size lack access undiagnosed dementia feedback suggested video empowered reassured awaiting assessment could used tool reduce barriers early diagnosis patients carers involved making video found therapeutic activity
community engagement migrants identified important element developing individual well cohesive multicultural receiving communities depth interviews study explores profile moroccan migrant leaders community organizations receiving context south spain reasons engage moreover analyzes relationship established community engagement well results show migrants commit intrinsic support compatriots extrinsic increase social connection reasons social action positive influence well activates following paths improvement bicultural competences development social relationships receiving members strengthening social bonds compatriots increase abilities dealing unjust social conditions new environment decrease prejudice towards cultural group
study design cervical decompression cervical fusion patients medicare part claims data objective evaluate complication rate associated risk factors cervical spine surgery using national sample elderly patients summary background data number cervical spine procedures united states risen along associated hospital costs postoperative complications lead longer hospitalizations greater costs methods demographic information postoperative complications days evaluated multivariate cox regression used evaluate risk factors complications adjusting age socioeconomic status charlson comorbidity index race census region sex year surgery results medicare patients identified dataset respiratory complications urinary retention acute delirium nausea vomiting commonly diagnosed complications complications incidence less older patients higher risks respiratory complications procedures patients charlson scores also higher risk respiratory complications males higher risk urinary retention patients dementia higher risk acute delirium patients aged years higher risk acute delirium along patients transient ischemic attack stroke age also significant risk factor acute delirium patients females significantly higher risk nausea vomiting conclusion data help provide baseline information regarding complication rates elderly patient population united states serve help minimize complications
skeletal muscle satellite cells play critical role muscle growth homoeostasis regeneration selective induction muscle determination genes myf myod mrf prenatal development potentially impact reported functional heterogeneity adult satellite cells accordingly expression myf reported diminish self renewal potential majority satellite cells contrast virtually adult satellite cells showed antecedence myod activity examine priming myogenic cells mrf throughout development using cre lox based genetic strategy novel highly sensitive pax reporter alleles compared ubiquitous rosa based reporters show adult satellite cells independently anatomical location embryonic origin primed mrf expression given mrf cre mrf nlacz active exclusively progenitors embryogenesis whereas later expression restricted differentiated myogenic cells findings suggest adult satellite cells emerge embryonic founder cells mrf locus activated therefore level myogenic priming induction mrf compromise potential founder cells assume upstream muscle stem cell state propose embryonic myogenic cells majority adult muscle stem cells form lineage continuum elsevier inc rights reserved
background context sitting spinal alignment increasingly recognized factor influencing strategy deformity correction considering individuals sit longer hours slumped rather erect posture greater understanding natural sitting posture warranted purpose study aimed investigate differences sagittal spinal alignment two common sitting postures natural patient preferred posture erect investigator controlled posture commonly used alignment studies design setting randomized prospective study young healthy patients seen tertiary hospital month period patient sample twenty eight patients men women mean age years range recruited study patients first episode lower back pain less months duration included exclusion criteria consisted previous spinal surgery radicular symptoms red flag symptoms previous spinal trauma obvious spinal deformity forward bending test significant personal family history malignancy current pregnancy outcome measures radiographic measurements included sagittal vertical axis sva lumbar lordosis thoracolumbar angle thoracic kyphosis cervical lordosis standard spinopelvic parameters pelvic incidence pelvic tilt sacral slope sagittal apex end vertebrae also measured methods basic patient demographics age gender ethnicity recorded lateral sitting whole spine radiographs obtained using slot scanner imposed erect natural sitting posture statistical analyses radiographical parameters performed comparing two sitting postures using chi squared tests categorical variables paired tests continuous variables results forward sva shift two sitting postures mean significant increase mean degrees kyphosis mean degrees well loss mean degrees mean increased degrees entire thoracic lumbar spine tendency form single shaped curve apex moving vertebra majority patients conclusions natural sitting posture lumbar spine becomes kyphotic contributes single shaped sagittal profile comprising thoracic lumbar spine associated increase well constant sva findings lend insight body natural way energy conservation using posterior ligamentous tension band achieving sitting spinal sagittal balance also provides information one possible causes proximal junctional kyphosis proximal junctional failure elsevier inc rights reserved
purpose overactive bladder affects general population almost third experience urinary incontinence may severely impact health related quality life oral anticholinergics mainstay pharmacological treatment limited inadequate efficacy side effects leading high discontinuation rate report results first large patients phase placebo controlled trial onabotulinumtoxina patients overactive bladder urinary incontinence inadequately managed anticholinergics materials methods eligible patients overactive bladder urgency urinary incontinence episodes days micturitions per day randomized receive intradetrusor injection onabotulinumtoxina placebo primary end points change baseline number urinary incontinence episodes per day proportion patients positive response treatment benefit scale posttreatment week secondary end points included overactive bladder symptoms health related quality life adverse events assessed results onabotulinumtoxina significantly decreased daily frequency urinary incontinence episodes placebo patients became completely continent larger proportion onabotulinumtoxina placebo treated patients reported positive response treatment benefit scale overactive bladder symptoms improved placebo onabotulinumtoxina improved patient health related quality life across multiple measures uncomplicated urinary tract infection common adverse event rate urinary retention observed conclusions onabotulinumtoxina showed significant clinically relevant improvement overactive bladder symptoms health related quality life patients inadequately treated anticholinergics well tolerated
order model design process pressure hull dedicated system based visual basic developed design process followed principle simple convenient smart patterns calculating checking built computer programming language using system designer get results quickly correctly
association cholesteryl ester transfer protein cetp gene polymorphism angiographically proven atherosclerosis cetp gene linked cad risk via role hdl ldl metabolism agreement whether cetp atherogenic furthermore various genotypes cetp gene associated cetp levels thus atherosclerosis risk aim study association cetp gene polymorphism cetp hdl levels association atherosclerosis study population consisted angiographically documented cases coronary artery atherosclerosis controls negative atherosclerosis coronary artery serum lipid profile measured synchron using standard kits serum cetp levels measured elisa method cetp gene polymorphism studied using pcr rflp method significant difference lipid profile two groups however serum cetp level significantly higher cases controls value frequency allele higher cases controls homozygosity allele subjects atherosclerosis coronary artery conclude cetp atherogenic could used atherogenic risk predictor angiographically proven atherosclerosis also allele polymorphism prevalent cases indicating effect expression cetp gene
article introduces new dataset historical family characteristics based ethnographic literature novelty dataset lies fact constructed level ethnic group test possibilities dataset construct measure family constraints women agency explore correlation number geographical factors
alzheimer disease common cause dementia currently effective disease modifying treatments available hallmark symptoms include impaired hippocampus dependent episodic memory disrupted sleep circadian rhythms pathways connecting symptoms particular interest well established sleep circadian disruption impair hippocampus dependent learning memory rodents procedures also markedly suppress adult hippocampal neurogenesis form brain plasticity believed play important role pattern separation thus episodic memory causal role sleep disruptions pathophysiology suggested evidence sleep dependent glymphatic clearance metabolic waste products brain review explores complementary hypothesis sleep circadian disruptions contribute cognitive decline activating neuroendocrine neuroinflammatory signaling pathways suppress hippocampal neurogenesis evidence hypothesis underscores promise sleep circadian rhythms neurogenesis therapeutic targets remediation memory impairment published elsevier inc
global water demand expected outstrip supply dramatically making water recycling important tool future water security large combined grey water rainwater recycling system monitored response identified knowledge gap use performance systems water saving efficiency system calculated compared predicted due lower quantity grey water rainwater collected system filter required backwash alone top potable water therefore required complete backwash process flush wcs urinals efficiency filter calculated much lower current figures used grey water saving predictions using direct mains water recycling system would efficient case highlighting importance realistic system analysis future installations
accurate timely knowledge critical intelligent transportation system leads improved traffic flow management knowledge past useful future traffic patterns normally follow predictable pattern respect time day day week paper systematically evaluated prediction accuracy speed several supervised machine learning algorithms towards congestion identification based six weeks real world traffic data august september maryland washington virginia area dataset consists six months traffic data pattern july december weeks used representative sample purposes study reference roadway experimental data shows respect classification classification tree ctree could provide best prediction accuracy accuracy rate prediction speed seconds pertinent note variations exist respecting prediction accuracy prediction speed hence tradeoff often necessary respecting priority applications question also imperative note outset algorithm design calibration important factors determining effectiveness
objectiveto review place therapy isavuconazole active metabolite isavuconazonium sulfate via review available literature drug chemistry spectrum activity pharmacokinetic pharmacodynamic profile trials assessing clinical efficacy safety methodsrelevant data original research articles reviews gathered primarily use pubmed database search search conducted without date restrictions order collect historical recent data regarding isavuconazole key findingsisavuconazole triazole currently approved use invasive aspergillosis mucormycosis also demonstrable activity candida species common fungal pathogens drug features make clinically appealing compared azoles similar indications specific isavuconazole require cyclodextrin vehicle due water solubility present require therapeutic drug monitoring moreover isavuconazole displayed improved safety tolerability compared voriconazole available data phase iii clinical trials shows isavuconazole possible therapeutic option currently available therapies approved however clinical conclusions reserved results published data clinical use reported conclusionsisavuconazole new triazole broad spectrum antifungal activity including invasive aspergillosis mucormycosis
method predicting shear strength materials multiple length scales developed tested method based oil renormalizing energies shear displacements obtained electronic structure calculations nanoscale models material interest material size dependent quantities incorporated renormalization factors yielding universal model applied many materials length scales model used predict shear strength cro along three relevant slip planes slip directions results demonstrate shear strengths nanoscale systems used calculations range gpa data renormalized predict shear strength grain thick yielding shear strengths ranging mpa large decrease shear strength increasing grain size consistent behavior many materials ability capture change using electronic structure calculations require experimental input may useful developing cohesive laws novel materials use large scale mechanical engineering simulations materials failure acta materialia inc published elsevier ltd rights reserved
paper develops bayesian inference extreme value models flexible time dependent latent structure generalized extreme value distribution utilized incorporate state variables follow autoregressive moving average arma process gumbel distributed innovations time dependent extreme value distribution combined heavy tailed error terms efficient markov chain monte carlo algorithm proposed using state space representation finite mixture normal distributions approximate gumbel distribution methodology illustrated simulated data two different sets real data monthly minima daily returns stock price index monthly maxima hourly electricity demand fit proposed model used model comparison estimation results show usefulness proposed model methodology provide evidence latent autoregressive process heavy tailed errors play important role describe monthly series minimum stock returns maximum electricity demand
formation homogeneous photodecomposition chromate ester often overlooked studies photocatalytic reduction hexavalent chromium presence sacrificial electron donors methanol photoexcited lambda chromate ester formed spontaneous reaction aqueous methanol undergoes homogeneous stepwise decomposition trivalent chromium iii addition semiconductor photocatalysts tio relatively low concentrations suppression rate reduction observed concentrations tested importantly work showcases parallel non independent effects homogeneous photodecomposition chromate ester photocatalytic reduction semiconductor photocatalysts elsevier rights reserved
although direct oral anticoagulants doacs require routine laboratory monitoring may special situations measurement drug levels desirable paucity information measurement doac levels used clinical practice conducted retrospective cohort study dabigatran rivaroxaban apixaban levels measured institution patients active prescription dabigatran rivaroxaban apixaban electronic medical record year study period patients underwent total doac measurements twenty patients rivaroxaban apixaban none dabigatran common indications measurement inpatients surgery breakthrough thrombosis bleeding ambulatory setting patient characteristics suspected lead derangements drug levels extremes body weight gastrointestinal malabsorptive disorders served frequent indication among preoperative patients doac levels influenced decisions timing surgery outpatients levels within expected ranges affirmed current management small number patients breakthrough thrombosis bleeding identification drug levels expected concentrations led change anticoagulant regimen conclusion doac measurement infrequently requested indications differed hospitalized patients outpatients clinical response varied drug level indication
although considered common bariatric procedure laparoscopic adjustable gastric banding lagb associated high rates weight loss failure long term complications purpose study assess safety outcome conversion failed lagb laparoscopic sleeve gastrectomy lsg one hundred nine patients underwent conversion lagb lsg females mean age years mean bmi patient demographics obesity related morbidities bmi procedure post operative complications length hospital stay documented cases completed laproscopically performed single stage fourteen patients developed early post operative complications including two leaks three post operative bleeding mortalities series average bmi least year following surgery excess weight loss ewl data suggests conversion failed lagb lsg safe effective randomized controlled studies comparing conversion failed lagb sleeve gastrectomy versus bariatric operations necessary clarify optimal conversion procedure
fine scale population distribution data building level play essential role numerous fields example urban planning disaster prevention rapid technological development remote sensing geographical information system gis recent decades benefited numerous population distribution mapping studies however studies focused global population environmental changes considered fine scale population mapping local scale largely lack reliable data models geospatial big data booms internet collected volunteered geographic information vgi used solve problem article establishes novel framework map urban population distributions building scale integrating multisource geospatial big data essential fine scale mapping population distributions first baidu points interest pois real time tencent user densities rtud analyzed using random forest algorithm scale street level population distribution grid level design effective iterative building population gravity model map population distributions building level meanwhile introduce densely inhabited index dii generated proposed gravity model used estimate degree residential crowding according comparison official community level census data results previous population mapping methods method exhibits best accuracy pearson rmse produced fine scale population map offer thorough understanding inner city population distributions thus help policy makers optimize allocation resources
experimental identification dynamic models heat transfer walls needed optimal control characterization building energy performance models use heat equation time domain put matrix form state space representation transformed transfer function infinite order however model acts low pass filter needs respond frequency spectrum present measured inputs order transfer function determined using frequency spectrum measured inputs accuracy sensors main idea two models different orders one lower order used building parameter identification difference outputs negligible lower output measurement error homogeneous light wall used example detailed study examples homogeneous building elements high low time constants given first order model compared high order model hundreds states considered almost continuous space elsevier ltd rights reserved
lysinuric protein intolerance lpi rare autosomal recessive disease caused mutations slca gene encoding light subunit cationic amino acid transporter symptoms mimic primary urea cycle defects dysimmune symptoms also described renal involvement lpi first described appeared could concern much lpi patients could lead end stage renal disease common feature proximal tubular dysfunction nephrocalcinosis glomerular lesions also reported however little known regarding histological lesions associated lpi gathered every kidney biopsy lpi proven patients highly specialized pediatric adult institution clinical biological histological information analyzed five lpi patients underwent kidney biopsy institution clinically presented proximal tubular dysfunction nephrotic range proteinuria histology showed unspecific tubulointerstitial lesions nephrocalcinosis biopsies marked peritubular capillaritis one child glomerular lesions heterogeneous lupus like full house membranoproliferative glomerulonephritis mpgn one child evolved towards monotypic igg mpgn sensitive immunomodulators one patient presented glomerular non non amyloidosis renal biopsy particularly relevant lpi presenting glomerular symptoms variable histological lesions responsible implying specific treatment follow elsevier inc rights reserved
help symbolic computation system maple riccati equation mapping approach linear variable separation approach new family complex solutions dimensional boiti leon pempinelli system blp derived based derived solitary wave solution novel complex wave localized excitations obtained
course last decade fast qualitative computing power developments undoubtedly permitted better realistic modeling complex physiological processes due favorable environment fast generic reliable model high density surface electromyographic semg signal generation multilayered cylindrical description volume conductor presented study main peculiarity lies generation high resolution potential map skin related active motor units mus indeed analytical calculus fully performed frequency domain semg signals obtained surfacic numerical integration generated high resolution potential map following variety electrode shapes suggested model implemented using parallel computing techniques well using object oriented approach comprehensive enough fairly quickly understood used potentially upgraded illustrate model abilities several simulation analyses put forward results section simulations performed muscle anatomy varying number processes order show significant speed improvement accuracy numerical integration method illustrating electrode shape diversity also investigated comparison analytical transfer functions definition additional section provides insight volume detection circular electrode according radius furthermore large scale simulation introduced mus muscle semg electrode grid composed electrodes three constant isometric contractions finally advantages limitations proposed model discussed focus perspective works elsevier ltd rights reserved
objectives shown hypothyroidism induced oxidative damage brain tissue involved adverse effects learning memory nigella sativa sativa suggested antioxidant neuroprotective effects objective study investigate effects hydroalcoholic extract sativa hypothyroidism associated learning andmemory impairment neonatal juvenile growth rats methods thirty pregnant rats kept separate cages delivery mothers offspring randomly divided six groups including control ptu propylthiouracil ptu ptu ptu ptu vit vitamin dams except control group received ptu drinking water lactation besides ptu dams groups received sativa extract vit respectively lactation period pups continued receive experimental treatment first weeks life male offspring group randomly selected assessed learning memory abilities using morris water maze mwm passive avoidance tests blood samples collected thyroxine assessment animals euthanized brain tissues removed analyzed total thiol groups malondialdehyde mda concentrations results ptu exposure significantly increased time latency mwm test reduced time spent target quadrant decreased latency entering dark compartment test effects associated significant reduction serum thyroxine levels brain levels thiol groups significant elevation hippocampal mda administration sativa extract vit reduced time latency increased time spent target quadrant compared ptu group mwm test treatment sativa extract also vit significantly increased time latency entering dark compartment test serum thyroxine concentrations animals treated doses sativa extract well vit higher ptu group two hundred four hundred milligrams kilogram extract vit decreased mda concentration hippocampal tissues increased thiol contents compared ptu group discussion results study demonstrate hydroalcoholic extract sativa protective effects hypothyroidism associated learning memory impairment neonatal juvenile growth rats effects comparable vit might due protective effects sativa extract brain tissues oxidative damage
objectivea higher trans epidermal water loss tewl occurs rough skin elder skin also atopic dermatitis impaired skin barrier function considered caused incomplete construction intercellular lamellar structure due quantitative reduction ceramides since symptoms coexist oxidative stress hypothesized impairment skin barrier function accelerated oxidative stress thus purpose study clarify effect oxidative stress ceramide synthesis characterize whether antioxidants improve skin barrier function laurylglyceryl ascorbate newly amphipathic derivative ascorbic acid evaluated candidate antioxidant methodswe characterized mrna expression levels serine palmitoyltransferase spt normal human epidermal keratinocytes nheks treated using real time pcr analysis order evaluate effect skin barrier function used several assays reconstructed human epidermis equivalents rhees resultsceramide synthesis regulated nheks oxidative stress treatment abrogated regulation spt mrna nheks caused oxidative stress stimulated spt mrna expression levels experiments characterizing antioxidative properties reduced oxidative stress nheks regulating catalase mrna expression addition stimulated skin barrier function rhees lower tewl values compared untreated rhees furthermore increased quantity ceramide rhees conclusiontaken together conclude reinforces skin barrier function due reduction oxidative stress promotion ceramide synthesis resume objectifune plus haute perte eau trans epidermal tewl produit dans peau rugueuse dans peau ainee aussi dans dermatite atopic considere une fonction barriere peau diminuee est provoquee par une construction incomplete structure lamellar intercellulaire raison reduction quantitative ceramides comme ces symptomes coexistent avec tension oxidative nous etions hypothetiques que affaiblissement fonction barriere peau est accelere par tension oxidative ainsi cette etude etait clarifier effet tension oxidative sur synthese ceramide caracteriser les antioxydants peuvent ameliorer fonction barriere peau laurylglyceryl ascorbate qui est nouvellement amphipathic derive acide ascorbique ete evalue comme antioxydant candidat methodesnous avons caracterise les niveaux expression mrna serine palmitoyltransferase spt dans epidermal humain normal ker atinocytes nheks traite avec utilisant pcr temps reel analy sis pour evaluer effet sur fonction barriere peau nous avons utilise plusieurs essais avec epider humain reconstruit mis les equivalents rhees resultatsla synthese ceramide ete bas regulee dans nheks par tension oxidative traitement avec abroge bas egu lation spt mrna dans nheks provoque par tension oxidative spt stimule mrna niveaux expression dans caractere experiences izing les proprietes antioxidative reduit tension oxidative dans nheks par catalase regulant haut mrna expres sion plus stimule fonction barriere peau dans rhees qui avait plus bas des valeurs tewl comparees avec rhees non soigne outre augmente quantite ceramide dans rhees conclusionpris ensemble nous concluons que contiennent force fonction barriere peau raison reduction oxidative tension promotion synthese ceramide
studies amyotrophic lateral sclerosis als profiled disease specific features condition conjunction assessment caregivers burden distress quality life investigated patient survival eighty four als patients primary caregivers enrolled patients completed als specific measures physical cognitive function caregivers completed measures anxiety depression caregiver burden quality life patient caregiver dyads interviewed health service utilisation survival data obtained irish register als participants dichotomised low high groups according severity self reported caregiver burden based statistically derived cut scores high burdened caregivers significantly differ low burdened caregivers respect disease specific characteristics alsfrs bulbar spinal onset als disease duration survival data however significant differences reported subjective measures anxiety depression distress quality life data demonstrate limited impact als patient related variables alsfrs onset caregiver burden als identify importance psychological composition caregivers study suggests subjective experience individual caregivers important factor influencing severity experienced caregiver burden
paper focus attacks based sniffing like mitm counter network layer perspective already developed algorithm called pathfinder allows forward segments packets via different paths ensure attacker able get hands entire message transmitted paper start recalling first version pathfinder algorithm followed introduction newest release allows handle hundreds nodes network finally put algorithm test simulating sniffing attack wireshark simulation proves addition efficiency handle great number nodes new way routing help facing lot attacks based sniffing type attacks like dos
multivariate approach based principal component analysis pca anomaly detection received lot attention networking community one decade ago mainly thanks work lakhina workers however work criticized several authors claimed number limitations approach neither original proposal critic publications completely aware established methodology pca anomaly detection time developed three decades area industrial monitoring chemometrics part multivariate statistical process control mspc theory paper main steps mspc approach based pca introduced related networking literature reviewed highlighting differences mspc drawbacks approaches specificities challenges application mspc networking analyzed demonstrated illustrative experimentation supports discussion reasoning elsevier ltd rights reserved
hypercube network one popular parallel computing networks since simple structure easy implement locally twisted cube newly introduced variant hypercube number nodes number connections per node hypercube half diameter better graph embedding capability compared hypercube paper show dimensional locally twisted cube constructed forming matching nodes two disjoint copies dimensional hypercube addition embed locally twisted cube path minimum layout
present work parallel lattice boltzmann multiphase model developed investigate effects surface structures wettabilities flow dynamics microchannel theory wetting transition firstly discussed three types including triangular rectangle hierarchical shaped microstructures constructed surface examine effects wettabilities drag reduction found flow behaviour strongly affected surface morphology channel results indicated hierarchical structures surface could improve hydrophobicity significantly rectangular structures improve hydrophobicity increase height distance ratio structures improvement reach optimal hydrophobicity value certain value moreover accelerate computational speed open multiprocessing openmp employed parallelization model maximum speedup times obtained threads multi core cpu platform elsevier ltd rights reserved
developed software package incorporates integrated computational materials engineering principles enable rapid development new state art atomistic potentials metal behavior driven initio experimental data software features hand tuning abilities well automated calibration parameters flexible target properties molecular statics simulations target properties done using built lammps library module boost performance potential calibration method flexible intuitive allowing users quickly develop potentials complex alloys capturing wide variety behaviors demonstrate validity software technique calibrating new robust potential
long term monitoring shoreline changes significant importance coastal erosion prediction coastal planning paper presents use landsat archival dataset years monitor shoreline changes narrabeen collaroy beach australia scene landsat data vector based shoreline subpixel level automatically extracted employing super resolution border segmentation method monthly cross shore beach profile surveys five locations along beach used ground truth data assess results experimental results show correction tidal effects rmses time series shorelines five locations less rmses annual mean shorelines within results achieved within context narrabeen collaroy beach observed vary width period addition observed variabilities shoreline change different locations along long embayment also clearly observed landsat derived results results indicate feasibility landsat data long term shoreline change monitoring society photo optical instrumentation engineers spie
conduct narrative literature review using four real world cases clinical decisions show barriers use evidence based medicine affect physician decision making point care adjustments could made healthcare system address barriers four cases constitute decisions typical types physicians make regular basis diagnostic testing initial treatment treatment monitoring shed light opportunities improve patient care reducing costs focus barriers could addressed changes policy practice particular level healthcare system conclude relating findings passage medicare access children health insurance program reauthorization act april
past decade thailand pursued strategy promoting biofuel crop production including sugarcane meet ever increasing energy demand increase income farmers study analyzed influence policy instruments implemented promote sugarcane cultivation farm household socioeconomic levels biophysical institutional factors driving conversion rice fields sugarcane farms primary information collected farm households structured questionnaire relevant policy documents published responsible government agencies main sources secondary information collected policy analysis analyses revealed farmers study area converted rice fields sugarcane farms result implementation policy instruments made sugarcane financially far attractive rice results regression analysis showed eight variables found significant positively influenced conversion rice fields sugarcane farms access extension services information sugarcane loading stations ground water irrigation duration experience sugarcane farming well household head age education irrespective landholding size majority farmers concerned food security view finding feasible form additional price supports commercial cane sugar index based pricing strategies promote sugarcane production benefit concerned farmers likewise attention paid deliver essential extension marketing services effective way particularly farmers receiving services
purpose review emergency contraception provides critical time sensitive opportunity women prevent undesired pregnancy intercourse access available options emergency contraception changed last several years recent findings emergency contraceptive pills less effective obese women maximum achieved serum concentration levonorgestrel lng lower obese women women normal bmi doubling dose lng increases concentration maximum approximating level normal bmi women receiving one dose lng repeated use lng ulipristal acetate upa well tolerated hormonal contraception immediately started following lng use delayed days upa use avoid dampening efficacy upa copper intrauterine device iud iud approved emergency contraception effective method emergency contraception use lng iud emergency contraception currently investigated accurate knowledge emergency contraception remains low patients healthcare providers summary emergency contraception important yet underutilized tool available women prevent pregnancy current options including copper iud emergency contraceptive pills safe well tolerated significant gaps knowledge emergency contraception provider user level exist barriers expedient access emergency contraception
research infiltration trench equipped extensive pretreatment filter bed consisting woodchip sand gravel utilized low impact development technique manage stormwater runoff highly impervious road particular emphasis heavy metal removal findings revealed major factors influencing removal heavy metals concentration particulate matters heavy metals runoff runoff volume flow rates reduction heavy metals enhanced sedimentation particulates pretreatment fine particles significant amount heavy metals thus enhanced adsorption filtration using various filter media important design considerations sediment highly attached surface area woodchip filter media like sand gravel geotextile suggested maintenance must performed end winter season wherein high sediment rate observed maintain efficiency treatment system
objectivethere evolving debate pathological affective responses patients anorexia nervosa examined startle responses different stages methodswe applied startle reflex paradigm standardized visual stimuli international affective pictures system food body pictures female participants acute chronically ill long term recovered healthy controls measured subjective ratings valence anxiety electromyographic startle responses resultsparticipants acute chronic displayed subjective valence ratings affective stimuli showed less startle reactivity affective pictures compared healthy control food pictures rated unpleasant higher anxiety provoking currently ill discussionwe observed diverging subjective psychophysiological reactions different stages psychophysiological methods help attain comprehensive understanding biological alterations long term course copyright john wiley sons ltd eating disorders association
computation penalized quantile regression estimates often computationally intensive high dimensions paper propose coordinate descent algorithm computing penalized smooth quantile regression cdasqr convex nonconvex penalties cdasqr approach based approximation objective check function differentiable zero modified check function differentiable zero using maximization minimization trick gcdnet algorithm yang zou comput graph stat update coefficient simply efficiently implementation consider convex penalties nonconvex penalties scad mcp establishe convergence property csdsqr penalty numerical results show implementation order magnitude faster competitors using simulations compare speed algorithm competitors finally performance algorithm illustrated three real data sets diabetes leukemia bardet bidel syndrome gene expression studies
aim increased afferent fibre activity contributes pathological conditions overactive bladder syndrome nerve fibres running near urothelium considered afferent efferent system yet described aim study identify sub types afferent nerve fibres mouse bladder wall based morphological criteria analyse regional differences materials methods bladders six month old cbl mice removed tissues processed immunohistochemistry cryostat sections cut stained protein gene product pgp calcitonin gene related polypeptide cgrp neurofilament vesicular acetylcholine transporter vacht neuronal nitric oxide synthase nnos results sub urothelium different types afferent nerve fibre found immunoreactive cgrp vacht nnos bladder base sub urothelium densely innervated cgrp vacht nerve fibres lateral wall nnos nerves sparsely distributed sub urothelium throughout bladder lateral wall inner muscle densely innervated cgrp nerve fibres vacht nnos nerves evenly distributed different muscle layers throughout bladder nerve fibre terminals expressing cgrp found within extra mural ganglia bladder base conclusions different types afferent nerve fibres identified sub urothelium mouse bladder bladder base sub urothelium densely innervated lateral wall cgrp vacht afferent nerve fibres cgrp afferent nerve fibres muscle layer probably relay afferent input external ganglia located near bladder base identification different afferent nerves sub urothelium suggests functional heterogeneity afferent nerve fibres urinary bladder elsevier rights reserved
growing complexity cyber physical systems together increasingly available parallelism provided multi core chips fosters parallelization simulation simulation speed ups expected simulation parallelization based model splitting weakly coupled submodels framework functional mockup interface however slackened synchronization submodels associated solvers running parallel introduces integration errors must kept inside acceptable bounds choptrey denotes forecasting framework enhancing performance complex system simulation trivalent articulation first consider framework computationally hasty online prediction system allows improve tradeoff integration speed ups needing large communication steps simulation precision needing frequent updates model inputs second smoothed adaptive forward prediction improves simulation accuracy obtained past weighted extrapolation based causal hopping oblivious polynomials third signal behavior segmented handle discontinuities exchanged signals segmentation performed contextual hierarchical ontology patterns implementation strategies simulation results demonstrate framework ability adaptively relax data communication constraints beyond synchronization points sensibly accelerate simulation choptrey framework extends range applications standard waring lagrange polynomial extrapolation often deemed unstable embedding predictions lag dependent smoothing discontinuity handling demonstrates practical efficiency
past research established clear support prosocial function gratitude improving well others present research provides evidence another hypothesized function gratitude social alignment function enhances tendency grateful individuals follow social norms tested social alignment hypothesis gratitude studies large samples using different conformity paradigms participants subjected color judgment task experiment material consumption task experiment provided information showing choices allegedly made others allowed state responses private supporting social alignment hypothesis results showed induced gratitude increased private conformity specifically participants induced feel gratitude likely conform purportedly popular choice even option factually incorrect experiment effect appears specific gratitude induction joy produced significantly less conformity gratitude experiment discuss whether social alignment function provides behavioral pathway role gratitude building social relationships
paper introduces current issues challenges future directions nuclear thermalhydraulic safety research viewed close conjunction new developments advanced reactor systems simulation tools lessons learned fukushima accident two technical concerns introduced illustrate limitations current understanding important phenomena relevant nuclear safety first reflood heat transfer important safety issue long time second multidimensional phenomena appearing nuclear reactor systems rather recently drawn significant attention nuclear community concerns discussed taking recent research examples emphasizing critical relevance nuclear reactor safety challenging issues advancement nuclear safety technologies identified briefly discussed close conjunction recent research efforts perspectives advanced nuclear safety research presented
relevant information positron emission tomography currently obtained mostly analog signal processing methods new digital pet scanner architectures becoming available offer greater flexibility easier reconfiguration capability compared previous pet designs moreover new strategies devised extract information better accuracy digitized detector signals trained artificial neural networks ann investigated improve coincidence timing resolution different types avalanche photodiode apd based detectors signal output charge sensitive preamplifier digitized shelf free running mhz bit analog digital converter time discrimination performed anns implemented field programmable gate array fpga results show anns particularly efficient slow low light output scintillators bgo less faster luminous crystals lso reference fast pmt plastic detector time resolution achieved bgo apd detector lso ann found competitive digital techniques developed previous works anns implemented fpgas provide fast flexible circuit easily reconfigured accommodate various detectors different signal noise conditions
objective cool little kids parenting group program effective intervention preventing anxiety disorders young children risk inhibited temperament program six group sessions delivered trained psychologists parents year old children online adaptation cool little kids online developed overcome barriers wide dissemination community study tested efficacy cool little kids online randomized controlled trial method total parents child aged years inhibited temperament randomized online parenting program week waitlist online program interactive modules providing strategies parents implement child manage child avoidant coping reduce parental overprotection encourage child independence parents provided telephone consultation support psychologist requested parents completed self report questionnaires baseline weeks baseline results intervention group showed significantly greater improvement time child anxiety symptoms compared control group intervention group also showed greater reductions anxiety life interference lower rates anxiety disorders control group versus minimal effects broader internalizing symptoms overprotective parenting conclusion results provide empirical support efficacy online delivery cool little kids program online dissemination may improve access evidence based prevention program child anxiety disorders
base stations equipped resources harvest renewable energy environment friendly also reduce grid energy consumed thus bringing cost savings cellular network operators intelligent management harvested energy increase cost savings management energy savings carefully coupled managing quality service ensure customer satisfaction process trade energy drawn grid quality service unlike prior studies mainly focus network energy minimization paper proposes framework jointly managing grid energy savings quality service terms network latency achieved downlink power control user association reconfiguration use real deployment scenario london show performance proposed framework compare existing benchmarks show proposed framework lead around grid energy savings well better network latency performance traditionally used scheme
background study explored details immune response autologous hematopoietic stem cell transplantation ahsct treatment type diabetes mellitus methods peripheral blood mononuclear cells pbmcs patients type diabetes mellitus taken baseline months ahsct insulin therapy lymphocyte proliferation mrna expression secretion pro inflammatory anti inflammatory cytokines belonging helper type helper type regulatory treg cells pbmc culture supernatants assessed results compared patients receiving insulin treatment patients receiving ahsct treatment showed better residual peptide secretion lower anti gad titers less exogenous insulin dosages months follow ahsct treatment associated significantly reduced cell proportions well decreased ifn gamma levels pbmc culture supernatants although significant treg cell expansion ahsct treatment observed increased tgf beta foxp mrna expression increased tgf beta levels however found significant changes cell subpopulations insulin treatment except higher mrna expression lower proportion treg cells conclusions ahsct treatment associated decreased expansion function cells may explain better therapeutic effect ahsct compared traditional intensive insulin therapy
transforming growth factor beta tgf beta induced differentiation lung fibroblasts myofibroblasts key event pathogenesis pulmonary fibrosis study aimed evaluate effect curcumin tgf beta induced differentiation lung fibroblasts myofibroblasts explore underlying mechanism mouse lung fibroblasts cultured treated tgf beta curcumin rosiglitazone cell vitality examined mtt assay secretion collagen assessed elisa alpha smooth muscle actin alpha sma visualized immunofluorescence technique expression peroxisome proliferator activated receptor gamma ppar gamma platelet derived growth factor beta pdgfr beta detected pcr western blot analysis found curcumin rosiglitazone inhibited proliferation tgf beta induced differentiation mouse lung fibroblasts addition curcumin rosiglitazone inhibited collagen secretion alpha sma expression mouse lung fibroblasts furthermore curcumin rosiglitazone upregulated ppar gamma downregulated pdgfr beta expression mouse lung fibroblasts conclusion study reveals novel mechanism curcumin inhibits tgf beta driven differentiation lung fibroblasts myofibroblasts curcumin could potentially used effective treatment pulmonary fibrosis
dna methylation epigenetic modification dna methyl group added fifth carbon cytosine base form methyl cytosine without altering dna sequences plays important roles regulating many cellular processes modulating key genes expression alteration dna methylation patterns becomes particularly important aetiology different diseases including cancers abnormal methylation pattern could contribute pathogenesis cancer either silencing key tumor suppressor genes activating oncogenes thus dna methylation biosensing help better understanding cancer prognosis diagnosis aid development therapies last decades plethora optical detection techniques developed analyzing dna methylation using fluorescence raman spectro scopy surface plasmon resonance spr electrochemiluminescence colorimetric readouts paper aims comprehensively review optical strategies dna methylation detection also present overview remaining challenges optical strategies still need focused along lesson learnt working techniques
voriconazole broad spectrum triazole antifungal agent metabolized cytochrome cyp lesser extent cypa genetic polymorphism cypc plays prominent role disposition may also influence potential drug interactions cyp modulators ritonavir study assessed way drug interactions voriconazole added ritonavir boosted atazanavir cypc extensive metabolizer poor metabolizer healthy subjects subject received voriconazole alone days followed day washout atazanavir ritonavir daily given days voriconazole days voriconazole doses days twice daily days twice daily cypc subjects respectively coadministration voriconazole auc min decreased respectively cypc ems whereas voriconazole max auc increased fold fold fold fold fold fold respectively pms adding voriconazole resulted decrease atazanavir min ems pms ritonavir exposure generally unchanged either population safety tolerability profiles combination comparable atazanavir ritonavir voriconazole administered alone frequent adverse events voriconazole visual disturbance headache coadministration voriconazole atazanavir ritonavir recommended unless benefit risk patient justifies use combination
efficient facile hydrothermal route dictated synthesis flower like mos photocatalyst developed scanning transmission electron microscopy characterization show detailed morphologies mos microflowers ray diffraction photoelectron spectroscopy analysis confirm obtained product hexagonal mos phase photocatalytic properties flower like mos evaluated degradation rhodamine rhb methylene blue natural sunlight irradiation synthetic value could dictate mos performance exhibited best response amongst samples published elsevier
research paper summarizes results implementation fuzzy multilevel methodology rank software reliability measures late computer based systems used largely monitoring protecting control safety critical systems like nuclear power plants aircraft etc reliability important factor assessing performance safety critical digital systems characteristics digital safety critical systems explicitly implicitly reflected software engineering measures therefore help measures models built predict reliability software applications run safety critical systems necessary every software engineering measures contribute predict reliability hence need ranked based influence reliability since sufficient practical data available literature expert opinion selected software engineering measures contributing reliability based criterion sought expert ratings aggregated ranked using chen fuzzy logic based ranking method data involved kind problems inherently imprecise inexact application fuzzy set theory suitable situations top ranked software engineering measures later used develop model predict reliability safety critical digital systems
understanding need improvement efficiency electric vehicle drivetrain system paper exclusively discusses various design aspects permanent magnet machine drive direct drive electric vehicles firstly motivation employ direct drive configuration discussed thereafter initial electric machine rating design considerations typical supermini segment employing direct drive configuration discussed furthermore employing existing stator investigations performed analytical equations designed machines understand different permanent magnet machine design aspects regards selection number poles type permanent magnet rotor stator winding configuration number phases study performed assist providing decision points various structural design indices machine venturing fea based permanent magnet machine design assessment direct drive application
paper presents interesting new applications field analog signal processing focused signal generation novel modifications recently developed studied family active elements called voltage differencing buffered amplifier vdba voltage differencing inverted buffered amplifier vdiba discussed attention focused simple application active elements like dual output vdbas vdbas fully balanced vdbas vdbas one two terminals always voltage outputs polarities present last modification vdba allows additional electronic control voltage gain frame active element except standard transconductance control discussed active elements used build simple multiphase oscillators minimal complexity simple non tunable alternative classical conceptions utilizing lossy integrators phase shifted loop linearly tunable quadrature differential mode balanced oscillator balanced simple triangle square wave generator chosen useful examples features proposed circuits discussed selected examples verified evaluated computer simulations appropriate low voltage tsmc cmos technology models
fuzzy sets intersection procedure select optimum sizes analog circuits composed metal oxidesemiconductor field effect transistors mosfets presented cases study voltage followers vfs current feedback operational amplifier cfoa width length mosfets selected space feasible solutions computed swarm evolutionary algorithms evaluation three objectives namely gain bandwidth power consumption performed using hspice standard integrated circuit technology vfs cfoa therefore intersection procedure among three fuzzy sets representing gain close unity high bandwidth minimum power consumption presented main advantage relies usefulness select feasible sizes automatically considering deviation percentages desired target specifications basically assigning threshold fuzzy set result proposed approach selects best feasible sizes solutions guarantee enhance performances ics analog signal processing applications
growing body research focused relationship childhood trauma risk developing psychosis numerous studies including many large scale population based studies controlling possible mediating variables provide persuasive evidence dose response association indicative causal relationship existing evidence supports specificity model showing differential associations particular adversities clinical symptoms cumulative adversity causing less favorable clinical functional outcomes psychotic patients date several psychological biological models proposed search underlying developmental trajectories leading onset psychosis influencing psychopathological manifestation negative functional outcomes due history childhood trauma article provide unified review relationship childhood trauma psychosis integrating results epidemiological clinical neuropsychological biological studies question whether psychosis positive history childhood trauma considered new psychotic phenotype requiring specific therapeutic interventions warrants investigation elsevier ltd rights reserved
objective compare baseline disease activity treatment effectiveness biologic naive patients nonradiographic axial spondyloarthritis axspa ankylosing spondylitis initiate tumor necrosis factor inhibitor tnfi treatment study role potential confounders hla status methods observational cohort study based prospectively registered data nationwide danbio registry used kaplan meier plots cox logistic regression analyses study effect diagnosis axspa potential confounders sex age start hla disease duration tnfi type smoking baseline disease activity tnfi adherence response bath ankylosing spondylitis activity index basdai results study included tnfi naive patients axspa axspa lacked radiographs sacroiliac joints patients axspa frequently women hla negative compared tnfi start patients axspa higher visual analog scale scores median quartiles pain global fatigue basdai however patients axspa lower reactive protein bas metrology index hla negativity associated poorer treatment adherence hla negative positive axspa lower response rates axspa conclusion nationwide cohort patients axspa higher subjective disease activity start first tnfi treatment similar outcomes patients confounder adjustment hla positivity associated better outcomes irrespective axspa subdiagnosis
intergroup conflict evident throughout history species ubiquitous across human societies considered crucial evolution humans large scale cooperative nature like humans chimpanzee societies exhibit intragroup coordination coalitionary support violent intergroup conflicts species cooperation among group members essential individuals gain access benefits engaging intergroup conflict studies suggest contributive mechanism regulating group cooperation intergroup conflicts humans involves neuropeptide hormone oxytocin known influence trust coordination social cognition although evidence natural settings lacking applying noninvasive method investigate oxytocinergic system involvement natural intergroup conflicts wild chimpanzees found chimpanzees sexes significantly higher urinary oxytocin levels immediately intergroup conflict compared controls also elevated hormone levels linked greater cohesion intergroup conflicts rather level potential threat posed rival groups intragroup affiliative social interactions coordinated behavior alone thus oxytocinergic system potentially engendering cohesion cooperation facing group threat may uniquely human rather mechanism evolutionary roots shared last common ancestor chimpanzees likely expediting fitness gains intergroup conflict
purposeductal carcinomas dcs lacrimal gland rare aggressive malignancies investigated lacrimal gland potentially clinically actionable targets search new therapeutic options methodscase year old man presented diplopia xerophtalmia case year old man presented headache proptosis chemosis case year old man presenting chemosis corneal abscess three cases characterized morphologically including immunohistochemistry genetically fluorescence insitu hybridization fish one case next generation sequencing ngs cancer relevant genes resultscases composed large rounded irregular cystic nodules carcinoma cells prominent central comedonecrosis whereas case scirrhous morphology high expression ema characteristic three tumours androgen receptor intensely positive case scattered cells case negative case whereas oestrogen progesterone receptor consistently negative genetically hemizygous deletion point mutation pten identified case whereas amplification found cases conclusionthis study identified spectrum genetic events pattern protein expression lacrimal gland similar subset carcinomas breast ductal carcinomas salivary glands therapeutic purposes aberrations several components especially signalling pathway could alleviate effect directed therapy illustrating inadequacy isolated testing
development efficient visible light driven photocatalysts water splitting drawn much attention herein demonstrated novel producing photocatalytic system employed nitrogen doped graphene quantum dots ngqds znnbo heterostructures hydrogen evolving catalysts prepared ngqds znnbo heterostructures favorable light harvesting charge separation showed highly efficient photocatalytic performance water splitting hydrogen results showed znnbo mole ratio amount ngqds displayed important influence production moreover optimum synthesis conditions mole ratio amount ngqds obtained corresponding ngqds sample performed much higher hydrogen evolution rate mol studies enhanced photocatalytic activity could ascribed crucial roles ngqds heterojunction photocatalytic system resulted efficient charge separation largely enhanced photocatalytic activity meanwhile possible photocatalytic mechanism ngqds znnbo also proposed envision work creates new opportunities constructing designing efficient visible light driven photocatalysts hydrogen evolution reaction published elsevier
necessary sufficient conditions positivity reachability electrical circuits composed resistors coils capacitors given minimum energy control problem positive electrical circuits formulated solved procedure computation optimal input minimal value performance index proposed illustrated numerical examples
background allergic contact dermatitis known occur children without atopic dermatitis data needed contact sensitization profiles two groups objectives identify frequent allergens children without atopic dermatitis suspected allergic contact dermatitis methods retrospective analysis children aged years patch tested performed results children tested suspected contact dermatitis developed one positive reactions proportions children without atopic dermatitis respectively children atopic dermatitis reacted often lanolin alcohol pet amerchol fragrances fragrance mix myroxylon pereirae allergens outside european baseline series frequently gave positive reactions groups included cocamidopropyl betaine amerchol reactivity allergens significantly common atopic dermatitis children conclusion sensitization prevalences children without atopic dermatitis similar children atopic dermatitis reacted significantly often lanolin alcohol fragrances testing additional series besides european baseline series may necessary reactions example cocamidopropyl betaine amerchol may otherwise missed
reliable accurate short term subway passenger flow prediction important passengers transit operators public agencies traditional studies focus regular demand forecasting inherent disadvantages predicting passenger flows special events scenarios special events may disruptive impact public transportation systems thus given attention proactive management timely information dissemination study proposes novel multiscale radial basis function msrbf network forecasting irregular fluctuation subway passenger flows model simplified using matching pursuit orthogonal least squares algorithm selection significant model terms produce parsimonious msrbf model combined transit smart card data approach exhibits superior predictive performance prevailing computational intelligence methods non regular demand forecasting least min prior also leverages network knowledge enhance prediction capability pinpoint vulnerable subway stations crowd control measures three empirical studies special events beijing demonstrate proposed algorithm effectively predict emergence passenger flow bursts elsevier ltd rights reserved
basic framework conceptual understanding metallurgy alloys strong enabled use titanium alloys safety critical structures aircraft aircraft engines nevertheless focus cost effectiveness compression product development time effectively integrating design manufacturing applications well emerging bioengineering driven research recent decades towards greater predictive capability use computational materials engineering tools therefore paper focuses complexity variety fundamental phenomena material system focus phase transformations mechanical behaviour order delineate challenges lie ahead achieving goals acta materialia inc published elsevier ltd rights reserved
purpose pilot study explore feasibility intervention designed facilitate partner support lifestyle change among overweight obese adults serious mental illness smi fifteen adults smi enrolled lifestyle intervention community mental health centers participated self selected partner additional week intervention component designed facilitate social support health behavior change participants reported program useful convenient helped reach goals approximately two thirds participants baseline weight follow including achieving clinically significant weight loss participants reported significant increases partner support exercise use persuasive social support strategies partner support interventions promote exercising together positive communication may effective helping individuals smi initiate sustain health behavior change necessary reduce cardiovascular risk
aging population worldwide osteoporosis osteoporotic fractures becoming serious health care issue western world although less frequent women osteoporosis men relatively common problem hip vertebral fractures particularly relevant associated significant mortality disability since bone loss fragility fractures men recognized serious medical conditions several randomized controlled trials rcts undertaken males osteoporosis investigate anti fracture efficacy pharmacological agents commonly used treat postmenopausal osteoporosis overall treatments osteoporosis men less defined women mainly due fact fewer rcts performed male populations relatively smaller sample sizes lack long term extension studies however key question whether men expected respond differently osteoporosis therapies women pharmacological properties bisphosphonates teriparatide denosumab strontium ranelate make differentiation unlikely available clinical data support efficacy men primary osteoporosis well women series well designed rcts alendronate risedronate zoledronic acid teriparatide demonstrated reduce risk new vertebral fractures men presenting primary osteoporosis including osteoporosis associated low testosterone levels improve bone mineral density bmd preliminary studies ibandronate denosumab strontium ranelate also showed beneficial effects surrogate outcomes bmd markers bone turnover men osteoporosis although direct evidence non vertebral anti fracture efficacy lacking effects bisphosphonates denosumab teriparatide strontium ranelate surrogate outcomes bmd markers bone turnover similar reported pivotal rcts undertaken postmenopausal women vertebral non vertebral anti fracture efficacy clearly demonstrated conclusion sufficient data exist support use pharmacological agents men primary osteoporosis rcts warranted establish long term efficacy safety
paper controller automated steering articulated vehicle special capability reduce tracking low speed maneuvers proposed conventional tractor trailers large tracking low speed maneuvers proposed vehicle wheels tractor trailer steerable wheel steering controllers tractor trailer work independently one consists two layers fuzzy controller pid controller designed upper lower layer respectively control actuators aim controller ensure end points tractor trailer exactly follow path tractor first point assess performance proposed controller well steerability effect wheels low speeds trucksim simulation software used simulation results confirm proposed approach improves maneuverability accuracy path tracking compared conventional vehicles also conventional tractor active trailer scheme previously proposed number studies additionally reduces lateral tire forces enhance working life
emerging contaminants considered substances actual potential threat human health environment include endocrine disruptors pharmaceutical personal care products nanoparticles antibiotic resistance genes chemicals used packaging products etc disposal treatment emerging contaminants become key problem field water pollution control purpose review summarize published researches emerging pollutants treatment
paper drying process ginkgo biloba discussed process combined effect convective heat mass transfer hydromagnetic electrically conducting viscous improve ability drying important problem heat transmission drying process discussed parameter drying process determined ginkgo biloba drying machine developed key part drying machine designed whole drying machine developed enhance ability medical industry study help optimization drying process level ginkgo biloba drying
impedimetric genosensor fabricated detection hepatitis virus hcv genotype serum based hybridization probe complementary target cdna sample achieve probe dna complementary hcvgene immobilized surface methylene blue doped silica nanoparticles sinps modified fluorine doped tin oxide fto electrode synthesized sinps characterized using scanning electron microscopy sem high resolution transmission electron microscopy hrtem ray diffraction xrd pattern modified electrode ssdna sinps fro served signal amplification platform due silica nanoparticles sinps well electrochemical indicator due methylene blue detection hcv dna patient serum sample genosensor optimized evaluated sensor showed dynamic linear range copies detection limit copies sensor applied detection hcv sera hepatitis patient could renewed half life sensor weeks sinps fto electrode could used preparation gensensors also elsevier rights reserved
paper presents methodology design nonlinear robust controller attitude regulation implementation experimental platform unmanned aerial vehicle uav quadrotor details kinematic dynamic modeling based euler lagrange formalism provided well particulars design nonlinear robust infinity pid controller regulate rotational moments performance effectiveness proposed controller tested simulation experimental platform performance proposed controller compared conventional pid controller using integral square error ise performance parameter experimental results help demonstrate correct operation system real time applications presence unmodeled dynamics uncertainties parameters
invasive fungal infections children acute lymphoblastic leukemia major cause mortality recent reports described increasing incidence invasive non aspergillus mold infections patients hematological malignancies always challenging treat invasive fungal infection underlying hematological malignancies successfully report girl high risk acute lymphoblastic leukemia developed disseminated cunninghamella bertholletiae infection induction chemotherapy case illustrates difficulties diagnosis treatment invasive bertholletiae infection also highlights necessity physicians keep high suspicion awareness infrequent fungal infection copyright taiwan pediatric association published elsevier taiwan llc rights reserved
transport properties mechanisms fractured porous media important oil gas reservoir engineering hydraulics environmental science chemical engineering etc paper fractal dual porosity model developed estimate equivalent hydraulic properties fractured porous media fractal tree like network model used characterize fracture system according fractal scaling laws topological structures analytical expressions effective permeability fracture system fractured porous media tortuosity fracture density fraction derived proposed fractal model validated comparisons available experimental data numerical simulation shown fractal dimensions fracture length aperture significant effect equivalent hydraulic properties fractured porous media effective permeability fracture system increased increase fractal dimensions fracture length aperture remarkably lowered introducing tortuosity large branching angle also scaling law fracture density fractal dimension fracture length found scaling exponent depends fracture number present fractal dual porosity model may shed light transport physics fractured porous media provide theoretical basis oil gas exploitation underground water nuclear waste disposal geothermal energy extraction well chemical engineering etc
significant advancements field additive manufacturing past decades current technologies field allow fabrications complex physical prototypes also functional electronic components circuitries possible fabricate simple circuits embedded several kinds passive components example resistors capacitors inductors fundamental building blocks electrical circuits order aid future developments integrations printing electronics wider range applications review attempts provide overview recent developments fully additive printing techniques used fabricating circuits electronic components including comparisons advantages disadvantages individual fully additive printing technique presented discussed detail potentials challenges additive manufacturing electronics also discussed
shi hang belt mesozoic tectonic zone always regarded boundary yangtze cathaysia blocks occupies key tectonic location attracts considerable attention due dynamic formation mechanism however cenozoic dynamic process poorly constrained cenozoic activation shi hang belt well cooling exhumation aids dating onset time formation mountain ranges reveals deformation process south china block uncover history cenozoic cooling denudation apatite fission track aft thermochronology applied batholiths strata spread across shi hang belt hunan province twenty three samples dated ages ranging except two older ages ages range less variation sides chenzhou linwu fault thermochronological modelling measured samples demonstrates rocks rapidly passed aft partial annealing zone near surface different onset times regional aft cooling pattern unrelated internal structures shi hang belt characterized mesozoic fold thrust feature attribute cenozoic exhumation shi hang belt dynamic topography south china block related mantle downwellings upwellings due several episodes quick subduction pacific plate underneath eurasia late cretaceous early cenozoic oligocene early miocene far field effect india tibet collision may contributed exhumation shi hang belt
low back pain lbp one major disabling health conditions among older adults aged years older causes lbp among older adults non specific self limiting seniors prone develop certain lbp pathologies chronic lbp given age related physical psychosocial changes unfortunately review previously summarized discussed various factors may affect effective lbp management among older adults accordingly objectives current narrative review comprehensively summarize common causes risk factors modifiable non modifiable developing severe chronic lbp older adults highlight specific issues assessing treating seniors lbp discuss future research directions existing evidence suggests prevalence rates severe chronic lbp increase older age compared working age adults older adults likely develop certain lbp pathologies osteoporotic vertebral fractures tumors spinal infection lumbar spinal stenosis importantly various age related physical psychological mental changes spinal degeneration comorbidities physical inactivity age related changes central pain processing dementia well multiple risk factors genetic gender ethnicity may affect prognosis management lbp older adults collectively understanding impacts various factors assessment treatment older adults lbp clinicians researchers work toward direction cost effective personalized lbp management older people
adolescence developmental period marked considerable biological social psychological changes rates self reported stress rise mirroring adults mindfulness interventions increasingly implemented high schools improve students stress management psychosocial outcomes despite well researched role primary secondary control strategies management adolescent stress impact mindfulness attributions examined current study addressed gap extant literature mindfulness based martial arts program delivered high school students risk self regulation challenges measures primary secondary control cognitive errors completed pre post treatment compared waitlist control findings suggested students mindfulness program showed significant improvements secondary control reductions cognitive errors pre post treatment compared waitlist control significant group time changes found primary control findings discussed relation changes control related attributions associated cognitive behavioral therapy specific consideration possible mechanisms mindfulness may improve secondary control decrease cognitive errors directions future research discussed
paper presents novel frequency domain approach distributed harmonic analysis dha multi area interconnected electric power system within restructured environment proposed approach based decentralized structure harmonic analysis area independently conducted even limited available data via local computing resources large change sensitivity lcs concept applied secure platform account effects whole network single area interconnected power system frequency dependent models system elements accompanied existent harmonic assessment method utilized harmonic penetration calculation proposed dha approach capable finding exact values interconnected system using tcp communication facility moreover allows operator utility independently conduct dha within restructured power network developed method implemented existing software package applied several networks including ieee bus test system elsevier rights reserved
primary myelofibrosis pmf rarely diagnosed children cases children younger years old pediatric pmf generally follows benign course usually managed supportively blood transfusions prophylactic antibiotics infections present case year old girl diagnosed pmf age years computed tomography scan performed time appendectomy showed congenital asplenism knowledge third case myelofibrosis congenital asplenism reported literature whether asplenism contributed development myelofibrosis known
examined weeks capsaicinoid cap supplementation affected appetite body composition metabolic health markers seventy seven healthy male female volunteers randomly assigned ingest either low dose cap cap high dose cap cap capsimax placebo corn starch pla weeks baseline weeks weeks waist hip ratio body composition via dual energy ray absorptiometry dexa self reported calorie intakes appetite levels via council nutrition appetite questionnaire cnaq serum metabolic health markers analyzed moreover oral glucose tolerance test ogtt administered serum glucose insulin responses examined min post test drink consumption waist hip ratio significantly decreased cap although supplementation significantly affect body composition cap consumed less kcal compared pla difference kcal cap participants difference twenty three percent originally enrolled cap participants reported distress although participants cap group reported adverse events interestingly cap participants presented significant increases serum insulin well significant decreases serum hdl cholesterol levels however supplementation affect insulin response administered ogtt indices insulin sensitivity data suggest cap supplementation reduces self reported energy intake weeks supplementation cap supplementation also reduces waist hip ratio longer term effects capsaicinoid supplementation basal insulin cholesterol levels warrant investigation authors published elsevier ltd
literature development human vagina abundant however contributions concerning prenatal development entire utero vaginal anlagen uva rare carried rodents primary epithelial characteristics adult vagina uterus determined prenatal development depend epithelio mesenchymal stroma interaction thus investigation summarizing spatiotemporal distribution relevant molecular markers entire human uva current interest phenotyped epithelial mesenchymal characteristics sagittal sections female fetuses weeks gestation two female newborns immunostaining cytokeratins bcl bmp hox vegf sma pax vimentin epithelial differentiation followed caudal cranial direction uva due cytokeratin profile cytokeratins characteristics different epithelial zones uva could already recognized middle age fetuses vaginal epithelium originated urogenital sinus lower portion initiated transformation vimentin positive mullerian epithelium upper vaginal portion prenatal development original squamo columnar junction clearly detectable week onwards always found cervical canal early blc positivity within surrounding mesenchyme entire vagina including portio region pointed organ specific mesenchymal influence prenatal findings human specimens clearly show fornix epithelium squamo columnar junction vaginal mullerian origin cervical epithelium cranial squamo columnar junction uterine mullerian origin includes cells enough plasticity transform squamous epithelium
background next generation sequencing ngs allows ultra deep sequencing nucleic acids use sequence independent amplification viral nucleic acids without utilization target specific primers provides advantages traditional sequencing methods allows detection unsuspected variants infecting agents however ngs widely used small rna viruses incorrectly perceived cost estimates inefficient utilization freely available bioinformatics tools methods study utilized ngs based random sequencing total rna combined barcode multiplexing libraries quickly effectively simultaneously characterize genomic sequences multiple avian paramyxoviruses thirty libraries prepared diagnostic samples amplified allantoic fluids total rnas sequenced single flow cell illumina miseq instrument digital normalization data assembled using mira assembler within customized workflow galaxy platform results twenty eight avian paramyxovirus apmv one apmv four avian influenza two infectious bronchitis virus complete nearly complete genome sequences obtained single run avian paramyxovirus genomes displayed mean coverage based bases phred quality scores lower upper quartiles sample median depth per position samples respectively indicating coverage across samples sufficient deep variant analysis sample processing library preparation took approximately sequencing run took processing galaxy workflow took approximately cost steps excluding labor estimated usd per sample conclusions work describes efficient multiplexing ngs approach detailed analysis workflow customized tools characterization genomes rna viruses combination multiplexing ngs technology galaxy workflow platform resulted fast user friendly cost efficient protocol simultaneous characterization multiple full length viral genomes twenty nine full length near full length apmv genomes high median depth successfully sequenced samples applied novo assembly approach also allowed identification mixed viral populations samples
present collaborative attempt build select toolboxes scilab using external free open source software foss libraries interface written library scilab variables transferred variables computations carried one function calls variables returned scilab state art libraries octave coin opencv used build scilab toolboxes scilab selected frontend block based gui build models called xcos optimization signal processing communication image processing computer vision signal processing identification toolboxes advanced stages development use control systems scilab toolboxes early stages development
mobile network operators mnos deploying carrier grade wireless local area network wlan important complementary system cellular networks access network selection ans cellular wlan essential component improve network performance user quality service qos via controlled loading systems emerging heterogeneous networks characterized different cell sizes diverse wlan deployments automatic tuning network selection functionality plays crucial role article present two distinct self organizing network son schemes tuning ans long term evolution lte wlan systems son functions differ terms availability inter system information exchange internal algorithm design traffic load control system level simulations site specific dense urban network show proposed schemes improve significantly user quality service qos network capacity reference scheme offloading wlan performed simply based signal coverage
wrapping granular soils geosynthetic containers soilbags results considerable increase bearing capacity due effective restraint dilatancy soil paper numerically investigates stress states fabric anisotropies wrapped soil using discrete element method providing novel perspective new insights reinforcement mechanisms development constitutive relations soilbags two anticipated loading conditions namely unconfined compression simple shear considered numerical predictions compared experimental results unconfined compression global local stress paths evolve linearly slope global failure wrapping geosynthetic simple shear global stress path approaches critical state line first turns compression line wrapped soil local loading unloading stress paths observed may account high damping soilbags cyclic shear reduced fabric anisotropies normal tangential force chains suggest greater confinement lateral sides geosynthetic container either loading course performance mechanisms soilbag earth reinforcement method confinement interlocking better understood based new findings stress states fabric anisotropies elsevier ltd rights reserved
objective yale food addiction scale yfas questionnaire assesses food addiction based substance dependence criteria diagnostic statistical manual mental disorders dsm fourth edition text revision following recent updating addiction criteria new dsm version yfas developed study tested psychometric properties french yfas nonclinical population method assessed nonclinical participants french yfas eating behaviour eating disorder binge eating scale emotional overeating questionnaire three factor eating questionnaire questionnaire eating weight patterns revised eating disorder diagnostic scale tested scale factor structure confirmatory factor analysis based diagnostic criteria internal consistency construct incremental validity results prevalence results supported factor structure similar version diagnostic symptom count versions yfas good internal consistency kuder richardson alpha associated body mass index bmi binge eating uncontrolled emotional eating binge eating disorder cognitive restraint predicted bmi beyond binge eating frequency females higher prevalence males symptoms conclusions validated psychometrically sound french version yfas nonclinical population symptom count diagnostic versions future studies investigate psychometric properties questionnaire clinical populations potentially risk patients obesity diabetes hypertension metabolic syndrome risk factors
present study investigated activity oleuropein complex phenol present large quantities olive tree products opportunistic fungal pathogen candida albicans oleuropein found vitro antifungal activity minimal inhibitory concentration mic value morphological changes nuclei staining fluorescent dna binding dyes revealed apoptosis primary mode cell death analyzed samples treated subinhibitory concentrations oleuropein results suggest antifungal agent targets virulence factors essential establishment fungal infection noticed oleuropein modulates morphogenetic conversion inhibits filamentation albicans hydrophobicity assay showed oleuropein sub mic values significantly decreased aerobic anaerobic conditions cellular surface hydrophobicity csh albicans factor associated adhesion epithelial cells also demonstrated tested compound inhibits activity saps cellular enzymes secreted albicans reported related pathogenicity fungi additionally detected oleuropein causes reduction total sterol content membrane albicans cells might involved mechanism antifungal activity
low cost mini tubular microbial fuel cell mfc developed treating groundwater contained benzene monitoring wells experimental results indicate increasing length density reducing size char particles anode effectively reduced internal resistance additionally thinner polyvinyl alcohol pva hydrogel separator pva higher molecular weight improved electricity generation optimal parameters mfc anode density coke anode length pva mol separator thickness results continuous flow experiments reveal increasing sets mfcs connecting parallel markedly improved degradation benzene benzene removed electricity generated mfc ran continuously days without maintenance elsevier ltd rights reserved
programming one important areas computer science based many researches found programming subject highest failure rate universities hence several studies emphasized importance introducing programming early years education game based approach used study focusing primary school students literature survey exploratory case study executed implementing several learning activities using games questionnaires later distributed students activities completed findings research listed common game based approach introductory computer programming learners preferences towards games upper primary school students results study used basis development appropriate games suitable students age level
paper study resource allocation algorithm design distributed antenna multiuser networks full duplex radio base stations bss enable simultaneous uplink downlink communications considered resource allocation algorithm design formulated optimization problem taking account antenna circuit power consumption bss quality service qos requirements uplink downlink users minimize total network power consumption jointly optimizing downlink beamformer uplink transmit power antenna selection overcome intractability resulting problem reformulate optimization problem decoupled binary selection variables nonconvex constraints reformulated problem facilitates design iterative resource allocation algorithm obtains optimal solution based generalized bender decomposition gbd algorithm also propose simple technique improve speed convergence furthermore strike balance computational complexity system performance suboptimal resource allocation algorithm polynomial time complexity proposed simulation results illustrate proposed gbd based iterative algorithm converges globally optimal solution suboptimal algorithm achieves close optimal performance results also demonstrate tradeoff power efficiency number active transmit antennas circuit power consumption taken account particular activating exceedingly large number antennas may efficient approach reducing total system power consumption addition results reveal systems facilitate significant power savings compared traditional half duplex systems despite nonnegligible self interference
objectives increased aqueduct cerebrospinal fluid csf flow pulsatility recently reversed csf flow aqueduct suggested hallmarks idiopathic normal pressure hydrocephalus inph however findings adequately confirmed objective investigate flow blood csf inph compared healthy elderly order clarify flow parameters related inph pathophysiology materials methods sixteen inph patients years healthy subjects years underwent phase contrast magnetic resonance imaging mri measurements included aqueduct cervical csf flow total arterial inflow tcbf carotid vertebral arteries internal jugular vein flow flow pulsatility net flow flow delays compared multiple linear regression correcting sex age results aqueduct stroke volume higher inph healthy net aqueduct csf flow similar magnitude direction cervical csf stroke volume lower internal carotid artery net flow lower inph although tcbf differences found internal jugular vein flow flow delays conclusions typical flow blood csf inph mainly characterized increased csf pulsatility aqueduct reduced cervical csf pulsatility direction mean net aqueduct csf flow third fourth ventricle findings may reflect altered distribution intracranial csf volume inph although causality relationships unclear
fault diagnosis vehicle power system structure characteristics components complex module internal modules exist coupling cross linked mutual relations uncertainties system status working conditions difficult describe precisely mathematical model test cost expensive less fault samples thus fault diagnosis decision problem uncertain information small sample proposed combining multi signal flow graph model bayesian network fault diagnosis method fault diagnosis model power system corresponding bayesian network structure built achieve fault diagnosis power system diagnosis example shows method vehicle power higher failure troubleshooting capabilities system single multiple faults
system generating tunable orbital angular momentum oam radio beams method measuring oam states proposed experimentally investigated oam beams generated uniform circular array dynamically configured controlling digital signals baseband near field scanning platform built measure oam states system platform provide multiple feed ports transmitting array iteration used calibrate amplitude phase feed port experimental results demonstrate feasibility proposed methods generating measuring tunable oam beams
article explores czechoslovakia reacted persistence prostitution state socialism underlying marxist leninist ideology predicted disappear overthrow capitalism paper adopts law context approach critically analysing legal instruments well expert commentaries social scientists legal scholars judges prosecutors period argues czechoslovak state attempted suppress prostitution criminal law conceptualising parasitism many state socialist experts ultimately fell back extra legal normative system gender women prostitution condemned sexually promiscuous behaviour women blamed failing gender roles good women wives mothers whereas official policy thus enforcing socialist morality experts reverted traditional bourgeois morality clear betrayal promises marxism leninism state socialist ideology regards equality sexes heightened responsibility women given prevent prostitution unique state socialist czechoslovakia thus yet another case study repressive regime controls punishes vulnerable side prostitution transaction apportions blame gendered way instead demonstrates prostitution become vehicle promoting upholding traditional gender norms towards women prostitution women society
clinical assessment pupil appearance pupillary light reflex plr may inform integrity autonomic nervous system ans current clinical pupil assessment limited qualitative examination relies clinical judgment infrared video pupillography combined image processing software offer possibility recording quantitative parameters study describe video pupillography set intended human animal testing part validation resting pupil diameter measured human subjects using neuroptics irvine usa pupillometer compare measured video pupillography set plr assessed guinea pigs set consisted smart phone light emitting diode led strobe light light light cycles stimulus camera record pupil kinetics consensual response recorded video recording processed using custom matlab program parameters assessed resting pupil diameter constriction velocity percentage constriction ratio dilation velocity percentage dilation ratio report video pupillography set provided comparable results neuroptics pupillometer human subjects able detect larger resting pupil size juvenile male guinea pigs compared juvenile female guinea pigs juvenile age male guinea pigs also stronger pupil kinetics pupil constriction dilation furthermore video pupillography set able detect age specific increase pupil diameter female guinea pigs reduction male female guinea pigs animals developed juvenile months adult age months technique demonstrated accurate quantitative assessment pupil parameters may provide foundation development integrated system useful clinical applications
research leadership emergence typically focuses attributes emergent leader considering also attributes perceivers passage time develop complete theory leadership emergence short lived groups using expectation states theory overarching theoretical framework integrating surface deep level diversity literature theories self serving biases examine predictors leadership emergence short timeframes conduct field study military assessment boot camp pilot study main study use cross sectional longitudinal exponential random graph models analyze data participants abilities perceptions respective groups leaders find criteria people perceive leadership others change time easily noticeable attributes covert leadership relevant attributes people also rely leadership relevant attributes possess high levels inform perceptions leadership others integration expectation states theory attribute salience time theories self serving bias needed full understanding leadership emergence groups perceivers abilities instrumental shaping perceptions emergent leadership time theoretical practical implications discussed
aims characterize gastrointestinal adverse events aes different glucagon like peptide receptor agonists glp ras methods two retrospective intention treat analyses month patient level data conducted data three studies comparing exenatide weekly exenatide twice daily pooled one duration comparing exenatide weekly liraglutide analysed separately patient reported gastrointestinal aes classified upper lower incidences timing determined subgroups analysed associations gastrointestinal aes efficacy examined results nausea common gastrointestinal treatments fewer exenatide weekly treated exenatide twice daily liraglutide treated patients reported gastrointestinal aes respectively fewer exenatide weekly treated patients reported upper plus lower events liraglutide treated patients difference exenatide weekly twice daily significant within group women men reported gastrointestinal aes events occurrred early predominantly mild glycated haemoglobin reductions similar patients without gastrointestinal aes weight loss greater patients gastrointestinal aes exenatide weekly exenatide twice daily difference observed duration conclusions gastrointestinal aes less frequent exenatide weekly exenatide twice daily liraglutide combined upper lower events occurred less often gastrointestinal aes typically mild occurred early gastrointestinal aes affect glycaemic control may associated greater weight loss
developmental dyslexia neurodevelopmental disorder affecting reading acquisition diagnosed starting primary school thereby one main challenges obtain early identification even preschool years achieving goal could help children risk limit impact disorder aim created digital system composed various serious games designed predicting risk preschoolers potentially training specific skills impaired learning disability set serious games designed accessible device computer mouse keyboard also tablet touch interface younger children
conflicting reports protective effect hemophilia occurrence ischemic heart disease study focuses evaluation heart function patients hemophilia cross sectional case control study done patients hemophilia came hemophilia center data compared controls data collected charts heart function evaluated dimensional doppler pulse tissue doppler serum troponin level measured patients marker myocardial damage fifty patients hemophilia took part study male mean age years systolic blood pressure mean diastolic mean blood pressure higher patients five patients systolic hypertension patients diastolic hypertension mode echocardiography results showed interventricular septum diastole patients hemophilia mean significantly thicker control group mean tissue doppler echocardiography showed late diastolic velocity septum systolic velocity lateral mitral valve late diastolic velocity lateral mitral annulus late velocity tricuspid significant difference compared control group troponin enzyme level patients patients hemophilia higher blood pressure hypertension echocardiographic study patients hemophilia showed increase septal thickness changes diastolic dysfunction
design manufacturing dfm highly integral methodology product development starting concept development phase aim improving manufacturing productivity maintaining product quality design assembly dfa focusing elimination combination parts components boothroyd dewhurst knight cases relates performing function manufacture operation simpler way dfm following holistic approach dfm considerable background work required conceptual phase compensated shortening later development phases current dfm projects normally apply iterative step step approach eventually transfer developer team although dfm well established methodology years fraunhofer iao study found dfm still one key challenges german manufacturing industry new knowledge based approach dfm eliminating steps dfm introduced paul dirini concept focuses concurrent engineering process manufacturing engineering product development systems current product realization cycles depend rigorous back forth examine correct approach ensure compatibility proposed design dfm rules guidelines adopted company key achieving reductions incorporate dfm considerations early stages design process case study dfm application automotive powertrain engineering environment presented argued dfm database needs interfaced cad cam software restrict designers dfm criteria consequently notable reduction development cycles achieved case study following hypothesis current dfm methods improve product design manner claimed dfm method critical case identify dfa dfm recommendations program actions repeated appearance different sources repetitive dfm measures identified analyzed shown modified dfm process mitigate non fully integrated dfm approach
mycoses serious health problem especially immunocompromised individuals new imidazole bearing compound containing oxime functionality synthesized characterized different spectroscopic techniques used preparation new antifungal agents stereochemistry oxime double bond unequivocally determined via single crystal ray technique title compound chnocho crystallizes monoclinic space group circle circle circle beta circle molecules packed crystal structure eight intermolecular hydrogen bond interactions comprehensive spectral analysis title molecule performed based scaled quantum mechanical sqm force field obtained density functional theory dft calculations molecular docking study illustrated binding mode title compound target protein preliminary antifungal activity title compound determined using broth microdilution assay
background two dimensional barcoding potential enhance documentation vaccine encounters point care however currently limited environments equipped dedicated barcode scanners compatible record systems mobile devices may present cost effective alternative leverage vaccine vial barcodes improve vaccine product specific information residing digital health records objective mobile devices potential capture product specific information vaccine vial barcodes sought examine feasibility performance potential limitations scanning barcodes vaccine vials using different mobile phones methods unique barcode scanning app developed android ios operating systems impact variables scan success rate data accuracy time scan examined barcode size curvature fading ambient lighting conditions two experimenters performed trials times amounting total barcode scan attempts results successful scans performed evaluation zero produced incorrect data five millimeter barcodes slowest scan although seconds average barcodes fading success rate success rate deteriorated beyond fading curved barcodes took longer scan compared flat success rate deterioration observed vial diameter light conditions affect success rate scan time lux lux conditions lux impeded device ability scan successfully variability scan time observed across devices trials performed conclusions vaccine barcoding possible using mobile devices successful majority conditions examined manufacturers utilizing barcodes take consideration impact factors limit scan success rates future studies evaluate effect mobile barcoding workflow vaccine administrator acceptance
face face communication body orientation coverbal gestures influence information conveyed neural pathways underpinning comprehension nonverbal social cues everyday interaction part still unknown fmri data acquisition participants presented video clips showing actor speaking short sentences actor produced speech associated iconic gestures gestures visible either egocentric ego allocentric allo position participants asked indicate via button press whether felt addressed found significant interaction body orientation gesture addressment evaluations indicating participants evaluated ego conditions addressing anterior cingulate cortex acc left fusiform gyrus stronger activated egocentric versus allocentric actor position gesture context activation increase acc ego allo correlated positively increased addressment ratings egocentric gesture condition gesture related activation increase supplementary motor area left inferior frontal gyrus right insula correlated positively gesture related increase addressment evaluations egocentric context results indicate gesture use body orientation contribute feeling addressed together influence neural processing brain regions involved motor simulation empathy mentalizing hum brain mapp wiley periodicals inc
dateview freeware desktop database system structured storage retrieval geochronological information provides user friendly interface constructing queries based information database extract information specific units isotope systems age interpretations provinces terranes reference sources many characteristics geochronologists geologists might require subset records database selected users may choose several forms graph better visualise data available graphs include probability histograms age versus initial ratio epsilon age versus closure temperature simple locality latitude longitude graphs also available grouping data interpretation age interval graphs user customizable database may also shared colleagues intranet elsevier ltd rights reserved
objectivesto prospectively evaluate persistence solifenacin treatment previously untreated japanese female patients overactive bladder methodsa total previously untreated japanese female patients diagnosed overactive bladder given solifenacin daily prospectively followed years periodic evaluations drug persistence rate estimated using kaplan meier method solifenacin terminated patient come hospital receive prescription reason determined resultsafter solifenacin treatment overactive bladder symptom score average voided volume significantly improved maintained years month year year year persistence rates respectively major reasons solifenacin therapy discontinuation symptom resolution adverse events patients nocturia three times baseline lower persistence nocturia three times patients without detrusor overactivity baseline lower drug persistence detrusor overactivity conclusionsapproximately one quarter previously untreated japanese overactive bladder female patients continue solifenacin treatment years many patients discontinue solifenacin various reasons including symptom resolution adverse events
gesture recognition systems segmenting gestures complex background hardest critical part gesture segmentation prerequisite following image processing result segmentation direct influence result gesture recognition paper proposed algorithm adaptive threshold gesture segmentation based skin color first image transformed rgb color space ycbcr color space eliminating luminance component similarity graph skin color obtained gaussian model otsu adaptive threshold algorithm used carry binary processing similarity graph skin color segmentation skin color regions morphology method used process binary image determining location hands experimental results show detailed segmentation skin color using dynamic adaptive threshold improve noise resistance produce better results
using distributed task allocation methods cooperating multivehicle systems becoming increasingly attractive however effort placed various specific experimental work little done systematically analyze problem interest existing methods paper general scenario description system configuration first presented according search rescue scenario objective problem analyzed together mathematical formulation extracted scenario considering requirement distributed computing paper proposes novel heuristic distributed task allocation method multivehicle multitask assignment problems proposed method simple effective directly aims optimizing mathematical objective defined problem new concept significance defined every task measured contribution local cost generated vehicle underlies key idea algorithm whole algorithm iterates task inclusion phase consensus task removal phase running concurrently vehicles local communication exists former phase used include tasks vehicle task list optimizing overall objective latter reach consensus significance value tasks vehicle remove tasks assigned vehicles numerical simulations demonstrate proposed method able provide conflict free solution achieve outstanding performance comparison consensus based bundle algorithm
background itraconazole used treat fungal infections particular invasive fungal infections infants neonates many countries data sources literature search conducted ovid embase pubmed isi web science cnki google scholarship using following key words pediatric infant neonate fungal infection combination itraconazole based literature clinical experience outline administration itraconazole infants order develop evidence based pharmacotherapy results articles use itraconazole infancy related superficial fungal infections including tinea capitis sporotrichosis mucosal fungal infections opportunistic infections articles related systemic fungal infections including candidiasis aspergillosis histoplasmosis zygomycosis trichosporonosis opportunistic infections caused myceliophthora thermophila conclusions itraconazole safe effective dose per day short duration therapy superficial fungal infections per day systemic fungal infections infants good compliance cost effective treating infantile fungal infections profiles adverse events induced itraconazole infants similar adults children
care gaps evaluation treatment osteoporosis fragility fracture joint commission considering adoption core measures compared compliance two secondary fracture prevention programs institution incorporating strengths may provide best outcomes secondary fracture prevention purpose significant care gaps evaluation treatment osteoporosis occurrence fragility fracture joint commission considering adoption core measure set osteoporosis associated fractures including laboratory assessment bone density testing osteoporosis pharmacologic therapy compared compliance proposed measures two secondary fracture prevention programs patients hospitalized acute fracture open medical system methods conducted retrospective single center medical records review nurse practitioner led fracture liaison service fls physician led fracture prevention program fpp historical time without secondary fracture prevention program usual care baseline care primary outcomes completion five laboratory tests calcium hydroxy vitamin renal function liver function complete blood count order placement completion dual ray absorptiometry dxa scan within months prescription osteoporosis medication within months medication adherence months hospital discharge results completion five laboratory tests higher fpp versus fls dxa scan completion higher fpp fls statistically significant medication prescription months adherence months significantly higher fpp versus fls respectively conclusion incorporating strengths fls care coordination fpp physician direction may provide best outcomes secondary fracture prevention ensuring laboratory dxa testing initiating osteoporosis medication
caring hiv aids patients drug users requires health care workers hcws good knowledge issues cultural differences hcws combined professional ethics personal beliefs could also result conflicting attitudes leading difficulties related looking people affected hiv aids drug users cross sectional study carried assess attitude towards hiv aids patients drug users sample workers operating large university hospital southern italy total workers surveyed may november periodic occupational health surveillance questionnaire administered attitudes discrimination acceptance fear towards patients respondents showed average levels acceptance hiv aids drug user patients years experience professional training increased scores discrimination acceptance hiv aids acceptance drug users fear decreased factors positively influencing levels attitudes female younger supplementary education needed strengthen awareness hcws
purpose present study develop evaluate psychometric properties autism spectrum disorders child asd mothers children autism spectrum disorders mothers typically developing children ages years completed asd confirmatory factor analysis revealed factor structure asd fits data well comprising following factors nonverbal communication socialization verbal communication social relationships insistence sameness restricted interests asd associated high internal consistency test retest reliability discriminant validity demonstrated mean differences asd control group high correlations several subscales asd social communication questionnaire scq found showing concurrent validity high correlations several subscales found optimal cutoff scores autism asperger disorder pdd nos found via roc curve analysis clinical research implications well limitations discussed elsevier ltd rights reserved
background finland children spend lot time outdoors winter outdoor recreation winter wide variety effects children well although children subgroup vulnerable cold exposure remarkably little research done subject objective aim study describe children outdoor recreation cold exposure symptoms winter northern finland design descriptive quantitative study participants consisted children aged years living provinces lapland northern ostrobothnia finland data collected using electronic data logging thermometers fixed children outerwear month thermometers recorded environmental temperature every five minutes temperature data able discern exact amount duration children outdoor recreation addition information children cold symptoms collected structured daily entries results cold weather obstacle children outdoor activities finland however duration outdoor recreation shortened outdoor air temperature decreased significant differences boys girls terms time spent outdoors remarkably every child reported symptoms associated cold almost half children reported experiencing respiratory symptoms children also experienced cold pain numbness conclusions results study illustrate many varied effects cold exposure children health well order prevent negative health effects cold exposure children structured prevention strategies needed therefore children exposure cold studied future research also bring positive health effects outdoor recreation children growth development
crucial element navigating group conflict group members manage stigma imposed groups across three experiments propose group identification cause consequence self labeling stigmatizing group labels practice known reduce stigma experiment found group identification increased self labeling stigmatizing group label experiment individuals self labeled stigmatizing group label felt identified group reduced label perceived negativity also persisted longer group helping task effect partially mediated group identification experiment observers perceived self labelers identified group viewing label less negatively perceived group identification mediated relationship group identification critical component reappropriating stigmatizing labels provides insight highly identified members navigate group conflict negotiating group identity
methodology seminars developing manufacturing engineering presented often planning similar seminars noted seminars limited duration normal way overcome limitation prepare seminar educational documents students disposal seminar date point ict tools used virtual teaching like exe learning become significant advancement however paper considered elaboration seminar materials students also whole educational strategy seminars developing manufacturing engineering stated
background orthorexia nervosa defined pathological healthful eating aim study investigate whether difference orthorexic behaviours clinical non clinical groups different cultural contexts methods recruitment involved female patients anorexia nervosa healthy controls italy poland patients hcs italy poland respectively assessment orthorexic behaviours performed orto test results statistically significant differences found italian women group whereas difference polish women group found italian groups scored significantly higher polish ones orto conclusions differences found italian polish samples percentage individuals orthorexic behaviours suggested orto score cutoff mean orto scores groups suggesting cross cultural differences orthorexic behaviours whose meaning currently difficult understand
background hereditary angioedema hae rare genetic disease manifests intermittent painful attacks angioedema attacks vary frequency severity include skin abdominal life threatening laryngeal swellings study aimed develop patient reported outcome pro tool assessment hae attacks including management impact patients lives use clinical studies physicians general practice methods results open ended face face concept elicitation interviews hae patients argentina used develop first draft questionnaire hae patient reported outcomes questionnaire hae pro subsequently depth cognitive debriefing interviews performed hae patients brazil germany france following input eight multinational clinical experts cognitive interviews conducted germany patients experienced abdominal cutaneous laryngeal attacks varying severity levels included rounds interviews across rounds interviews patients discussed hae attack symptoms impacts treatments cognitive debriefing interviews explored patient understanding relevance questionnaire items interviews conducted face face following pre defined semi structured interview guide patient native language results patients reported variety hae symptoms attack triggers warning signs attack impacts treatment options used develop hae pro hae pro revised refined following input patients clinical experts final item hae pro provides assessment hae attack experience including symptoms impacts treatment requirements healthcare resource use loss productivity caused hae attacks conclusions patient expert input contributed development content valid questionnaire assesses concepts important hae patients globally hae patients across cultures consider hae pro relevant appropriate assessment hae attacks treatment
measurement weight loss bariatric surgery constant review order obtain ideal standard reporting weight loss several formulas proposed purpose goal analyse weight loss sleeve gastrectomy without antrum preservation different measurement formulas prospective randomised study patients patients initial section pylorus patients pylorus calculate following variables months surgery bmi excess weight loss ewl percentage excess bmi loss pebmil expected bmi pebmil corrected ebmi percentage total weight loss twl weight evolution similar groups reaching mean bmi respectively months surgery closer expected bmi twl follows trend losses exceeding although group tables percentiles made series regarding pebmil group reaches classified excellent group reaches classified good result ewl situates best results group group obtained lower percentage suboptimal results using ewl twl places group higher percentile group ebmi groups equally effective necessary standardised dynamic tables surgical technique becoming essential elements measure weight loss surgery
paper presents current differencing buffered amplifier active element analog signal processing support comparison conventional operational amplifier voltage mode also current mixed mode operations first part paper concentrates fundamental approach realization current differencing buffered amplifier second part concerned enhancement current differencing buffered amplifiers achieving low voltage high performance
home environments one subjects study regarding ambient intelligent systems various purposes including development assistance systems elderly energy consumption optimization sensing environmental state via different sensors first crucial component every ambient intelligent system work investigate use environmental sounds touch free audio based device recognition home environment purpose analyzed sound characteristics typical home appliances using different processing techniques using acquired knowledge develop flexible set features set manually determined automatically classify device specific acoustic fingerprints consisting significant subset features use established supervised learning techniques whereby optimized straightforward ones building recognition basis recognition fixed length sound buffers demand implemented live recognition mode real time environment monitoring providing runtime setup adjustments extended work recognition untrained simultaneously working known devices mixing records utilizing semi supervised learning anticipated promising results evaluation various aspects including recognition rate performance different combinations features well study reliability automatic mixing trained data
acquisition generalization specific behavioral skills key component dialectical behavior therapy dbt individuals borderline personality disorder bpd examined feasibility acceptability usability immediate effects dbt coach mobile phone application app designed specifically augment skills generalization interactive coaching dbt skills pilot study provided dbt coach installed mobile device adjunct months standard dbt among sample individuals bpd recent history attempted suicide nonsuicidal self injury nssi results indicate good acceptability usability dbt coach considerable person variability frequency app use median use times course treatment month follow period using hierarchical linear modeling approach analyses indicated dbt coach reduced subjective distress urges self harm following app use however use dbt coach related treatment outcomes except reductions nssi study first examine use mobile technology adjunct dbt highlights potential challenges incorporating apps treatment implications future research clinical utility discussed
order achieve rapid development process reduce time market new approaches investigated automotive body assembly design research presents prospective study using plant digital mock support industrialization process design reviews concept digital lot dlot introduced design object validate layout assembly processes alternative collaborative way result better synchronization manufacturing engineers quick identification key issues related future assembly process configuration
paper provides analysis time frequency domain electrical circuit described fractional differential equation order alpha parts per thousand currency sign use laplace transform fractional derivative caputo sense time domain emphasize delay rise settling times frequency domain interest cutoff frequency bandwidth asymptotes low high frequencies quantities depend order differential equation
objectives migraine diseases characterized severe headaches neurological systemic findings purpose study investigate prevalence migraine examine whether relationship atopic disorders parental history migraine asthma patients material methods total asthma outpatients diagnosis early late test reversibility showing reversible airway obstruction according hospital database included presence headache atopic symptoms parental history asthma atopic disorders migraine asked patients headache consultated neurology department investigated presence migraine diagnosis migraine headache made patients fulfilled international headache society ihs criteria results patients described headache patients headaches meeting ihs criteria migraine patients migraine aura atopic symptoms patients according parental history asthma atopic symptoms migraine parents patients atopic symptoms found significantly high rate headaches prevalence migraine significantly high patients parental atopic symptoms multiple logistic regression analysis identified gender parental history asthma allergia migraine smoking independent risk factors presence migraine asthmatics conclusion high prevalence migraine headaches patients asthma coexistence asthma headaches may related similar pathophysiological mechanism parental history common genetic compounds smoking may play role mechanism headaches asthma patients atopic symptoms family history questioned clinicians careful presence migraine
covariance covariance coc matrix formed auto cross correlation function acceleration responses structure white noise ambient excitation components function modal parameters structure contain information vibration modes structure compared general existing methods extracting modal parameters paper makes use coc matrix new pattern match criterion long term health monitoring damage localization quantification five bay three dimensional frame structure large amount measured data service suspension bridge also analyzed acceleration responses required compute covariance covariance matrix components matrix analyzed effects traffic flow environmental temperature studied finally strategy identify abnormal state bridge presented based properties coc components bridge coc matrix shown suitable analyzing huge amount measured data output structural damage detection without need analytical model
tested hypothesis parental support autonomy moderates effects societal threat safety development right wing authoritarianism rwa quasi experimental study performed italian university students societal threat safety fostered rwa among participants reported low levels parental support autonomy elsevier ltd rights reserved
background low testosterone levels common finding among men type diabetes mellitus tdm inversely related insulin resistance whether relationship holds true patients hypertension normal glucose tolerance prediabetes unclear methods recruited male outpatients essential arterial hypertension aged years anthropometric data collected oral glucose tolerance test ogtt performed homeostasis model assessment insulin resistance homa score calculated follicle stimulating hormone luteinizing hormone testosterone sex hormone binding globulin free testosterone measured concentrations sex hormones compared normoglucotolerant prediabetic diabetic patients non parametric tests applied appropriate verify differences among groups multiple linear regression used predict variability testosterone free testosterone results total serum testosterone concentration significantly lower tdm comparison normoglucotolerant subjects inversely related body mass index waist circumference pre post ogtt plasma glucose respectively pre postogtt plasma insulin homa similar associations observed free testosterone homa related testosterone free testosterone even patients normal glucose tolerance respectively multivariate analysis homa variable associated testosterone free testosterone plasma concentration conclusions males hypertension link insulin sensitivity hypothalamic pituitary gonadal axis maintained along entire spectrum glucose tolerance
people often talk others personal past discussions inherently selective selective retrieval memories course conversation may induce forgetting unmentioned related memories speakers listeners cuc koppel hirst cue defined forgetting part speaker within individual retrieval induced forgetting rif forgetting part listener socially shared retrieval induced forgetting rif however forgetting associated rif rif taken seriously mechanism shapes individual shared memories mechanism must demonstrated meaningful material ecologically valid groups first experiments extended rif unemotional experimenter contrived material emotional unemotional autobiographical memories strangers experiment intimate couples experiment merely overhearing speaker selectively practice memories extended results context free flowing conversation experiments experiments found rif rif regardless emotional valence individual ownership memories discuss findings terms role conversational silence shaping personal shared pasts
background aims low grade inflammation appears play etiological role cognitive decline however association inflammatory dietary pattern cognitive decline investigated aimed investigate dietary patterns associated inflammation whether diet associated cognitive decline methods analyzed participants women whitehall cohort study diet serum interleukin assessed used reduced rank regression methods determine dietary pattern associated elevated cognitive tests performed repeated association dietary pattern cognitive decline ages assessed using linear mixed models results identified inflammatory dietary pattern characterized higher intake red meat processed meat peas legumes fried food lower intake whole grains correlated elevated greater decline reasoning seen participants highest tertile adherence inflammatory dietary pattern confidence interval compared lowest tertile adjustment age sex ethnicity occupational status education total energy intake interaction across tertiles association remained significant multivariable adjustment similarly global cognition inflammatory dietary pattern associated faster cognitive decline multivariable adjustment interaction across tertiles associations stronger younger participants years reducing possibility reverse causation conclusions study found dietary pattern characterized higher intake red processed meat peas legumes fried food lower intake whole grains associated higher inflammatory markers accelerated cognitive decline older ages supports case research authors published elsevier ltd
diffusion behaviors single atoms half unit cells investigated via combining scanning tunneling microscopy first principles calculations despite similar adsorption sites half unit cells among elements diffusion dynamics show obvious differences two although obvious asymmetry found diffusion behaviors atoms two half unit cells asymmetry behaves way different atoms dual time character observed diffusions half unit cells theoretical calculations suggest different potential energy profile caused stronger hybridization states states make concept basin useless diffusion atoms inside half unit cells elsevier rights reserved
lung cancer leading cause cancer related deaths world conventional therapy lung cancer associated lack specificity access normal cells resulting cytotoxicity reduced cellular uptake drug resistance rapid drug clearance body emergence nanotechnology revolutionized treatment lung cancer focus nanotechnology target tumor cells improved bioavailability reduced toxicity recent years nanoparticulate systems extensively exploited order overcome obstacles treatment lung cancer nanoparticulate systems shown much potential lung cancer therapy gaining selective access tumor cells due surface modifiability smaller size review various novel nanoparticles nps based formulations discussed treatment lung cancer nanotechnology expected grow fast future provide new avenues improved treatment lung cancer review article also highlights characteristics recent advances designing nps therapeutic outcomes
paper puts forward novel design method permanent magnet synchronous generator pmsg significant advantage method output power pmsg prominently improved without increasing material costs main difference traditional design scheme volume permanent magnet remains unchanged entire design procedure maximum output power scheme found optimizing shapes change mechanical pole arc coefficient words method aims obtain maximum utilization design scheme produce effective magnet field generate larger output power dimension parameters pms different shapes calculated equivalent analytic geometry method verify availability novel method performed four common types pmsgs different rotor structures satisfactory performance results obtained comparison traditional machine design scheme also presented illustrate innovation priority finite element analysis method based ansoft maxwell applied electromagnetic models building simulation
paper presents controller design implementation high precision six degree freedom dof magnetically levitated maglev positioner high precision positioning system consists novel concentrated field magnet matrix triangular single moving part carries three three phase permanent magnet planar levitation motor armatures since single levitated moving part namely platen generates required fine coarse motions positioning system reliable potentially low cost three planar levitation motors based lorentz force law produce vertical force levitate triangular platen also control platen position orientation horizontal plane main contribution paper dof motions solely controlled magnetic forces without means support platen weight gravity suitable controller magnetic levitation system designed implemented platen regarded pure mass spring damping effects neglected except vertical directions single input single output digital lead lag controllers designed implemented digital signal processor dof fully magnetically levitated positioner total mass exhibits maximum travel range position resolution position noise root mean square demonstrated positioner sub microradian angular resolution axes maximum velocity achieved single moving part maglev positioner structure highly suitable semiconductor manufacturing applications wafer steppers several experimental motion profiles presented demonstrate maglev stage capability accurately tracking planar three dimensional paths
increasing use magnetic resonance imaging mri clinical diagnostics means patients physicians confronted often incidental findings literature fluctuating data incidence findings guidelines concerning procedure exist cases incidental aneurysms pituitary adenomas diagnostic therapeutic implications derived incidental findings depend multiple factors anatomical location patient age comorbidity patient wishes reason often makes sense refer patients incidental findings interdisciplinary neurological center early stage review frequent incidental cerebral findings epidemiological data imaging criteria possible recommendations procedure shown
examined progranulin pgrn levels cerebrospinal fluid csf samples acute phase patients neuromyelitis optica spectrum disorders nmosd compared results patients multiple sclerosis patients inflammatory neurological diseases oind non inflammatory controls nic csf pgrn levels nmosd patients significantly higher patients nics levels correlated csf interleukin levels csf cell counts csf protein levels improvements expanded disability status scale score affected total spinal cord lesion length nmosd patients elsevier rights reserved
paper single moving part planar positioner six coils designed implemented concentrated field permanent magnet matrix employed stationary part moving platen compact size light mass low center gravity moving platen carries three planar motor armatures two phases per motor force calculation based lorentz force law conducted volume integration order deal nonlinearity due trigonometric dependencies force current relation modified proportional integral derivative pid lead compensators designed computed currents close control loop obtain desired performances experimental results verified commutation law force calculation new design six coils allows simplification control algorithm reduced power consumption positioner maximum travel ranges rotation vertical axis degrees respectively positioning resolution rms position noise positioning resolution rotations vertical axis rad
brain derived neurotrophic factor bdnf plays pivotal roles neuronal function cleaved mature form bdnf mbdnf predominantly expressed adult brains critically determines effects however insufficient proteolytic processing pathology may lead precursor form bdnf probdnf thereby increased neuronal apoptosis synaptic weakening previous findings lab showed cognitive stimulation delayed memory decline mouse model alzheimer disease effect tightly associated augmented levels mbdnf view association present study explored whether altered cleavage bdnf could involved related traits triggered excessive amyloid beta beta pathology whether process could therapeutically targeted ala pathology patient samples experimental models triggered upregulation plasminogen activator inhibitor pai via jnk jun led inhibition plasmin regulated conversion mbdnf pharmacological inhibition pai pal sufficiently reverted induced tau hyperphosphorylation neurotoxicity chronic treatment old month mice oral administration pai resulted improved bdnf maturation cognitive function without inducing significant changes amyloid burden conclusion upregulation pai may critical mechanism underlying insufficient neurotrophic support increased neurodegeneration associated thus targeting bdnf maturation pharmacological inhibition pai might become potential treatment elsevier rights reserved
visual perception fundamental component robotics systems operating human environments specifically visual recognition prerequisite large variety tasks tracking manipulation human robot interaction consequence lack successful recognition often becomes bottleneck application robotics system real world situations paper aim improving robot visual perception capabilities natural human like fashion limited amount constraints acquisition scenario particular goal build analyze learning system rapidly trained order incorporate new evidence available purpose review state art coding pooling pipelines visual recognition propose two modifications allow improve quality representation maintaining real time performances coding scheme best code entries bce new pooling operator mid level classification weights mlcw former focuses entirely sparsity improves stability computational efficiency coding phase latter increases discriminability visual representation therefore overall recognition accuracy system exploiting data supervision proposed pipeline assessed qualitative perspective human robot interaction hri application icub platform quantitative evaluation proposed system performed house robotics data sets icubworld established computer vision benchmarks caltech pascal voc byproduct work provide robotics community implementation proposed visual recognition pipeline used perceptual layer complex robotics applications published elsevier
sea surface temperature sst plays fundamental role exchange heat momentum water vapor atmosphere ocean therefore measurement sst done ships buoys offshore platforms satellites past decades satellites increasingly used datasets wide areas obtained paper moderate resolution imaging spectroradiometer modis board terra aqua sst products examined validated coastal waters yellow sea using situ buoy data strict match method adopted view complexity variability coastal area resulting match ups terra aqua respectively modis sst agreed well situ buoy sst squared correlation coefficients terra aqua relative situ ssts satellite derived ssts bias degrees degrees standard deviation degrees degrees root mean square error degrees degrees terra aqua differences modis situ sst exhibited apparent seasonal variations accuracy modis sst products spring summer lower autumn andwinter could caused frequent sea fog along southern coast shandong peninsula sst bias approximately depended wind velocity low wind velocity could enhance diurnal sst amplitude bulk skin temperature difference however significant dependence bias air sea temperature difference surface flow velocity
paper presents novel designs concentric cylindrical thermoelectric generator ccteg annular thermoelectric module atem simulations carried compare performance atem conventional square shaped thermoelectric module stem heat pipe technology introduced heat sink system order enhance heat transfer radial direction exhaust gas flow new index termed heat transfer filling factor introduced quantities level space utilisation thermoelectric modules tems correlation coolant flow rate tem performance also carried experimental work also carried demonstrate viability using heat pipes heat transfer enhancement well proving viability design simulations indicate open circuit electric potential atem stem experimental results show ccteg system performs well various conditions results also demonstrate concept adding heat pipes heat sink system practical solution achieve higher thermoelectric generator teg performance maintaining compactness teg system heat transfer filling factor achieved ccteg system higher compared existing teg systems moreover higher coolant flow rate contributes obtaining better performance teg system important note introduced index give guidance optimisation design teg systems elsevier ltd rights reserved
background parkinson disease second common neurodegenerative disorder old age best known risk proportion elderly world increasing resulting larger pool people risk parkinson disease several neurodegenerative disorders also produce parkinson syndrome distinguishing variants possible pathological examination brain autopsy confirmed study years older onset parkinsonism cases reported clinical features different variants response treatment progression disease age group remain determined methods patients evaluated movement disorders clinic saskatchewan offered choice autopsy cost brain studied board certified neuropathologist results thirty cases clinical diagnosis parkinsonism onset years came autopsy twenty one parkinson disease alone two additional movement disorder progression parkinson disease accelerated dementia evolved earlier reported younger onset cases cases tolerated adequate dose improved levodopa conclusion parkinson disease common variant octogenarian population patients benefit levodopa tried drug diagnosis parkinsonism made authors published elsevier ltd
paper discusses empirical results study influence gender role identity representations violence young female students age attitudes towards violence well use violence interpersonal relations appear long realization interpersonal interaction authors proceeded assumption traditional ideas gender dichotomy features violent behaviour inadequate gender system modern society study sample consisted respondents authors used following research methods writing essay semantic differential bem sex role inventory bsri obtained empirical data indicated girls undifferentiated neutral gender role identity wider range representations violence compare respondents guided dichotomous models gender behaviour masculine feminine patterns girls undifferentiated polarized gender role identity able recognize large variety forms violence flexibly use combine various forms violence achieving goals corresponding circumstances sample girls typically feminine gender role identity less able notice unobvious forms violence especially interpersonal relations violence usually polar forms representations either physical psychological moreover girls typically feminine gender role identity perceived violence behavioural patterns could assessed violent given context findings study could useful improving practices prevention correction rehabilitation female violent convicts well reducing manifestations extreme forms female violence society
study three phase asynchronous motor driven broad based system described mathematical model converter sinus pulse width modulation three phase inverter mathematical model three phase asynchronous motor utilized order establish system creating system fuzzy logic pid controllers focused order get satisfactory results short settling time rotor speed low harmonic short settling time high phase current created mathematical models run matlab simulink direct voltage applied converter input voltage represented renewable energy source could obtained solar energy source direct voltage lower peak alternating voltage alternating voltage obtained output inverter drive induction motor firstly resistive inductive loads driven secondly three phase asynchronous motor asm driven low direct voltage simulation results given order demonstrate performance effectiveness proposed system
investigation paper cubic quintic nonlinear schrodinger equation describe propagation ultrashort pulses inhomogeneous optical fibre lax pair conservation laws constructed integrability equation verified gauge transformation spectral problem equation converted ablowitz kaup newell segur spectral problem nonautonomous solitons breathers derived based darboux transformation nonautonomous rogue waves obtained via generalized influence group velocity dispersion gain loss coefficient group velocity coefficient propagation interaction nonautonomous solitons breathers rogue waves also discussed gain loss coefficient influences amplitude nonautonomous soliton characteristic line velocity nonautonomous soliton dependent group velocity dispersion group velocity coefficient independent gain loss coefficient second order nonautonomous soliton two spectral parameters real part bound state structure formed intensity becomes amplified attractive procedure exist two types nonautonomous breathers quasi periods nonautonomous breathers given effects coefficients quasi periods also discussed group velocity dispersion influence trajectories nonautonomous breathers rogue waves gain loss coefficient affects backgrounds nonautonomous breathers rogue waves
objective examine reproductive coercion partner violence among college women design cross sectional descriptive setting large public university northeast united states participants inclusion criteria college women age enrolled either full part time english speaking screened positive relationship data women analyzed methods mail invitation participate electronic survey sent undergraduate graduate female students web link informed consent inclusion criteria provided students affirmed met inclusion criteria could proceed survey completion survey implied consent results nearly participants reported reproductive coercion including pregnancy coercion birth control sabotage women reported pregnancy coercion birth control sabotage told use birth control commonly reported act women reporting reproductive coercion also screened positive relationship violence confidence interval conclusion pregnancy coercion birth control sabotage occur among college women higher rates reported among women histories partner violence addition screening counseling partner violence college health providers assess reproductive coercion tailor contraceptive counseling discussions accordingly
introductionthe prevalence hypogonadotropic hypogonadism patients type diabetes mellitus higher general population leads detrimental effects metabolic control lipid profile body composition studies examined role type diabetes mellitus aimto determine prevalence patients type diabetes associated risk factors main outcome measuresclinical biochemical parameters gathered initial evaluation score creating different experimental models devised calculate risk individual type diabetes methodscross sectional study male patients type diabetes consecutively admitted diabetes outpatient clinics three urban hospitals participants caucasians aged years type diabetes duration months resultsone hundred eighty one male patients mean age years type diabetes duration years included fifteen patients representing prevalence confidence interval age odds ratio waist circumference insulin requirements independently associated presence model best predicted generated formula score xage xwaist circumference xinsulin requirements triglycerides age expressed years waist circumference insulin requirements triglycerides score showed sensitivity specificity diagnosis positive negative predictive values respectively conclusionsone men type diabetes presents condition associated age waist circumference insulin requirements simple formula based clinical parameters rule presence chillaron fernandez miro albareda vila colom fontsere pedro botet flores roux test study group age insulin requirements waist circumference triglycerides predict hypogonadotropic hypogonadism patients type diabetes sex med
number satellite sensors date centers increased continuously becoming trend manage process massive remote sensing data multiple distributed sources however combination multiple satellite data centers massive remote sensing data collaborative processing still faces many challenges order reduce huge amounts data migration improve efficiency multi datacenter collaborative process paper presents infrastructures services data management well workflow management massive remote sensing data production dynamic data scheduling strategy employed reduce duplication data request data processing combining remote sensing spatial metadata repositories gfarm grid file system unified management raw data intermediate products final products achieved processing addition multi level task order repositories workflow templates used construct production workflow automatically help specific heuristic scheduling rules production tasks executed quickly ultimately multi datacenter collaborative process system mdcps implemented large scale remote sensing data production based effective management data workflow consequence performance mdcps experiments environment showed strategies could significantly enhance efficiency processing across multiple data centers
background tissue engineered vascular grafts tevgs offer potential overcome limitations current approaches reconstruction congenital heart disease providing biodegradable scaffolds autologous cells proliferate provide physiologic functionality however current tevgs address diverse anatomic requirements individual patients study explores feasibility creating patient specific tevgs combining dimensional printing electrospinning technology methods electrospinning mandrel printed computer aided design based preoperative imaging ovine thoracic inferior vena cava ivc tevg scaffolds electrospun around printed mandrel six patient specific tevgs implanted cell free ivc interposition conduits sheep model explanted months histologic biochemical biomechanical evaluation results sheep survived without complications grafts patent without aneurysm formation ectopic calcification serial angiography revealed significant decreases tevg pressure gradients months grafts remodeled explant nanofiber scaffold nearly completely resorbed tevg showed similar mechanical properties native ivc histological analysis demonstrated organized smooth muscle cell layer extracellular matrix deposition endothelialization significant difference elastin collagen content tevg native ivc identified significant positive correlation wall thickness macrophage infiltration tevg conclusions creation patient specific nanofiber tevgs combining electrospinning printing feasible technology future clinical option preclinical studies involving complex anatomical shapes warranted
surgical resection standard treatment localized colorectal cancer common type gastrointestinal cancer however cases diagnosed metastasized apparently inoperable systemic chemotherapy provides alternative patients study aims evaluate therapeutic potential liposomal doxorubicin lipodox combination liposomal vinorelbine lipovnb colon carcinoma bearing mouse model vitro cytotoxicity dox vnb cancer cells determined mtt colony formation assays mice subcutaneously inoculated cells right hind flank tumor size reached mice assigned receive different treatment protocols pharmacokinetics micro single photon emission computed tomography ray computed tomography imaging biodistribution immunohistochemical staining studies performed survey therapeutic efficacy regimen based results pharmacokinetic study administration lipodox lipovnb affect individual systemic distribution lipodox retained longer blood lipovnb superior tumor growth retardation observed group received lipodox plus lipovnb administration namely injected lipodox plus vnb namely severe side effects detected group tumor muscle ratio derived dexoy fluorothymidine flt micro positron emission tomography pet images treated mice controls day respectively suggesting efficacious regimen xenografts results proliferating cell nuclear antigen pcna immunohistochemical staining consistent findings obtained flt micropet imaging study demonstrated lipodox combination lipovnb efficacious clinically used regimen lipodox plus vnb treatment colon carcinoma flt pet promising approach monitoring treatment outcome early stage
advent modern technology use biometric authentication systems rise core biometric system consists database contains biometric traits successfully enrolled users maintenance security database paramount must made sure contents database compromised foreign threats adversaries biometric encryption far successfully studied analysed technique used providing required level security biometric systems survey discuss intuition behind idea study deep key binding based mechanisms provide basic foundation future novel researches area addition latest available survey paper investigates details core ideas behind development fuzzy frameworks includes recent works available literature study concluded inspecting merging multimodal biometrics fuzzy systems discussing open challenges domain
control applications implemented using real time operating systems digital control theory based sampling intervals strictly met order get predictable behaviors however real time system may introduce execution jitters may cause unpredictable effects control application stability overshoot settling time may affected inadequate real time system used several papers proposed different mechanisms measure jitter real time system produces however jitter translated performance criterion control theory hand frequency domain techniques widely applied control theory designing control strategies well analyzing measuring performance control mechanisms paper frequency domain analysis used measure perturbations real time operating system may produce control application harmonic distortion defined criterion evaluate control performance application experiments show higher priority tasks likely used control tasks since perturbation produced utilization factor adequate control applications
nitrogen runoff paddy fields serves one main sources water pollution aim reduce runoff paddy fields fertilizer management inoculation arbuscular mycorrhizal fungi amf northeast china shuangcheng city heilongjiang province field experiment conducted using rice provided local norm fertilization including phosphorus potassium without inoculation glomus mosseae volume concentrations total dissolved particulate runoff water measured found local norm fertilization led runoff rice growing season accounting also found reduction fertilization cut runoff amf inoculation decreased runoff fertilizer level effect inhibited high fertilization combination inoculation amf local norm fertilization observed reduce runoff conclusively suggested contribution amf inoculation combined decreasing fertilization get attention slow water eutrophication reducing runoff paddy fields research center eco environmental sciences chinese academy sciences published elsevier
serotonin production expression receptors htrs occur early prenatal development recent evidence suggests addition classical role neurotransmitter regulates neuronal connectivity mammalian development modulating cell migration neuronal cytoarchitecture given variety htrs researchers difficulty clarifying specific role receptor subtype brain development signalling mediated protein coupled htar htr however associated neuronal plasticity thus hypothesized promotes neurite outgrowth htar htr involvement htar htr morphology rat hippocampal neurons evaluated treating primary cultures days vitro specific antagonists htar htr way respectively stimulation hippocampal neurons produced effect either number length primary neurites nonetheless blocked addition increased number primary neurites suggesting could inhibit neuritogenesis contrast induced secondary neurite outgrowth effect inhibited way results suggest serotonergic receptors participate secondary neurite outgrowth conclude htar htr regulate neuronal morphology primary hippocampal cultures promoting secondary neurite outgrowth wiley periodicals inc
presence diffuse focal axonal swellings fas hallmark cellular feature many neurological diseases traumatic brain injury among things fas significant impact spike train encodings propagate affected neurons leading compromised signal processing neuronal network level work merges first time three fields study signal processing excitatory inhibitory networks neurons via population codes decision making theory driven production evidence stimulus iii compromised spike train propagation fas demonstrate mathematical architecture capable characterizing compromised decision making driven cellular mechanisms computational model also leads several novel predictions diagnostics understanding injury level cognitive deficits including key finding decision making reaction times rather accuracy indicative network level damage results number translational implications including level network damage characterized reaction times simple cognitive motor tests
based bench scale opposed multi burner omb gasifier advanced visualization techniques particle evolution characteristics gasifier studied particle images different focusing planes obtained optical sectioning tomography ost method particle types principles transformation particle shape particle size distribution psd particle fragmentation characteristics statistically analyzed image processing results show burner plane contains particle types high temperature particle without wake htp low temperature particle without wake ltp high temperature particle high temperature wake htp htw low temperature particle high temperature wake ltp htw particle shapes burner plane mainly round round like particle fragmentation process burner plane violent usually accompanied sudden bursts would result change particle motion status probability relatively low space burner plane main regions particle pyrolysis particle types mainly low temperature particle low temperature wake ltp ltw particles burner plane higher fragmentation probability burner plane intense pyrolysis regions particle shapes become irregular median particle diameter slightly increased plenty ltp space burner plane refractory dome probability fragmentation around burner plane higher probability around burner plane indicates particle fragmentation probability take place char gasification stage pyrolysis stage omb gasifier closer refractory dome less number large particle smaller particles near refractory dome diameter less elsevier ltd rights reserved
mineralization sulfidic minerals including realgar orpiment pyrite occurs argillic alteration zones northeastern iran affects water quality health semi arid localities geochemical source ions surface ground waters examined evaluate potential effects sulfidic mineralization water quality surface groundwater samples analyzed determine major ions hco trace elements water rock interactions evaporation defined key phenomena groundwater chemistry using gibbs diagram concentrations arsenic varied higher calculated ionic ratios revealed anions cations surface ground waters originated partial leaching ion exchange alteration zones postulate primary source resulted oxidation bearing sulfide minerals orpiment realgar arsenopyrite argillic pyrite alteration zone high could provide alkalinity increase sulfide oxidation release water stable isotope data delta delta indicated origin waters mainly meteoric precipitation partial effects evaporation processes exchanging ions surrounding rocks confirms notion source analyzed ions including toxic geogenic hydrogeochemical process affected water chemistry thus environmental public health likely water rock interactions evaporation elsevier rights reserved
purpose china accelerated urbanisation leads directly pressure urban environment purpose paper identify best practices involved real sustainable community projects experience replicated future design methodology approach explore practical development experiences technological applications case study conducted involving document analysis semi structured interviews findings findings identify green technologies strategies used project planning design process social considerations project development also recognised providing comfort convenience safety residents furthermore research highlights fact sustainable communities incur less operational costs compared traditional ones therefore provide feasible option clients greater capability upfront investment originality value results research provide valuable references developers development sustainable communities china countries
paper index based approach proposed locate chlorine booster stations water distribution network chlorination common practice secondary disinfection essential protection microbiological regrowth contaminant intrusion however higher levels free residual chlorine frc may lead unwanted disinfectant products dbps taste odor complaints booster chlorination used maintain minimum levels frc requires proper selection booster locations approach proposed uses generic hydraulic water quality modeling software programmers toolkit predict frc total trihalomethanes tthms converted thereafter water quality index wqi heuristic algorithm maximum covering location problem mclp used optimization maximizes wqi tthm converted trihalomethane thm species using quadratic optimization cancer noncancer risk potentials finally required number booster stations recommended based trade analysis risk potentials wqi life cycle cost booster chlorination proof concept case studies conducted hypothetical municipal american society civil engineers
combined theoretical experimental investigation carried objective evaluating theoretical predictions relating two dimensional airfoil subjected high amplitude harmonic oscillation free stream constant angle attack current theoretical approaches reviewed extended purposes quantifying hound unsteady vortex sheet strength along airfoil chord resulted closed form solution valid arbitrary reduced frequencies amplitudes experiments bound unsteady vortex strength symmetric thick airfoil low angles attack measured dedicated unsteady wind tunnel maximum reduced frequencies velocity oscillations less equal boundary layer tripped near leading edge mid chord phase amplitude variations lift coefficient corresponded reasonably well theory near maximum lift coefficient overshoot data exhibited additional high frequency oscillation comparisons measured predicted vortex sheet indicated existence recirculation bubble upstream trailing edge sheds wake modifies kutta condition without boundary layer tripping mid chord bubble present strengthens flow deceleration shedding produces dramatically different effect instead lift coefficient overshoot per theory data exhibit significant undershoot undershoot also accompanied high frequency oscillations characterized bubble shedding summary location bubble subsequent shedding play decisive roles resulting temporal aerodynamic loads
health environmental sciences institute hesi developmental reproductive toxicology technical committee sponsored pharmaceutical industry survey current industry practices contraception use clinical trials objectives survey improve understanding current industry practices contraception requirements clinical trials governance processes set promote consistency compliance contraception requirements effectiveness current contraception practices preventing pregnancies clinical trials opportunities improvements current practices also considered survey results pharmaceutical companies identified significant variability among companies regard contraception practices governance clinical trials variability due primarily differences definitions areas scientific uncertainty misunderstanding differences company approaches enrollment clinical trials survey also revealed companies collected data manner would allow retrospective understanding reasons failure birth control clinical trials article suggestions made topics regulatory guidance scientific publications could facilitate best practice include provisions pragmatic definition women childbearing potential guidance animal data influence requirements male female birth control evidence based guidance birth control pregnancy testing regimes suitable low high risk situations plus practical methods ascertain risk drug drug interactions hormonal contraceptives
objective fetal programming hypothesis posits utero exposure stress alter prenatal brain development lifelong stress response however human studies linking objective prenatal stressors offspring mental illness especially depression rare purpose study examine association mothers exposure prenatal stressful life events sles offspring depression method sample comprised members prospective population based cohort avon longitudinal study parents children alspac mothers reported occurrence impact prenatal sles offspring depressive symptoms assessed using computerized version clinical interview schedule revised cis age well self report statements short mood feelings questionnaire smfq time points ages latent class growth analysis lcga used identify trajectories depressive symptoms across adolescence results adjusting potential confounders unit increase maternal sle scores range gestation associated increased offspring depressive symptoms beta major depression odds ratio age lcga revealed trajectories depressive symptoms high maternal sles fourth quartile associated membership trajectory characterized stable high levels depression age years conclusion results provide support fetal programming hypothesis demonstrating prenatal exposure acute stress associated offspring depression adolescence stress management may benefit expectant mothers
paper study cooperative cognitive radio networks consisting primary user multiple secondary users sus sus transmit sensed silent may interfere primary transmission due imperfect sensing primary activity sensed correctly sus cooperate assisting retransmission failed packets analyze packet throughput three variations proposed cooperation method signal flow graph based approach employed obtain closed form expressions packet throughput analysis done two cases individual sensing cooperative sensing furthermore characterize optimal transmission probability sus maximizes individual secondary packet throughput keeping queues system stable results present comparison throughput performance proposed cooperation methods different scenarios show benefits throughput
new method implemented designing self oscillating loop driving piezoelectric transformers implemented method based combining analog digital control systems digitized delay digitized phase shift self oscillating loop results precise frequency control ensures optimum operation piezoelectric transformer terms voltage gain efficiency work additional time delay implemented digitally first time bit digital analog converter self oscillating loop delay control setpoints updates rate khz allows control loop dynamically follow frequency changes transformer resonant cycle operation principle behind self oscillating discussed paper moreover experimental results reported
supporting learners affectively carrying stressful educational activities open research issue requires appropriate infrastructure recognizing emotional states reacting accordingly runtime paper describe open platform implemented named aicarp detect changes physiological signals associated stressful situations happens recommends learner relax delivering modulated sensorial support terms light sound vibration relaxation breath rate way taking advantage ambient intelligence learner perceive recommended action without interrupting learning activity case practicing oral exam second language signal acquisition system combines sensors libellium health platform others integrated hoc compared commercial system engineering obtaining similar outcomes identifying significant changes physiological signals learner experiments emotional reaction however cost aicarp much lower time open hardware flexible thus advantage providing runtime data processing user studies served evaluate participants perception sensorial support well calibrate delivery rule evaluate effectiveness support provided
need bridge gap western based psychotherapeutic intervention african psychotherapeutic interventions main objective paper order cross cutting issues psychotherapy nigeria reviewed review covered socio cultural economic conditions contemporary issues child maltreatment hiv aids chronic illness terrorism impact western civilization nigerian culture produced heterogeneous nigerian society described westernized traditional transitional types nigerians also salient peculiarities must taken consideration bridging gap western african based psychotherapy identified salient peculiarities adumbrated include frequent somatic complaints psychological origin beliefs spirits including ancestral spirits independent spirits supreme spirit god duties owed keep moral order given situation authors expressed uncertainty use western diagnostic illness categories also attempt made describe traditional methods treatment popular prayer houses traditional healers lessons learnt based cross cutting issues authors reported development harmony restoration therapy meseron treatment frameworks attempts indigenizing western psychotherapeutic methods proposed way forward cultural blend using culture based psychotherapeutic framework suggest applied societies
quite computer programs developed model power plant performance software codes geared toward modeling steady state operations usually sufficient conventional power plants solar thermal power plants undergo prolonged transient start shut operations due periodic nature solar radiation moreover large size solar field brings large residence time must considered accurately lag power generation novel scheme developed fine tune steady state solar power generation models accurately take account impact transient operations suggested new scheme implemented adjusting solar radiation data input model shown clearly improve modeling accuracy moving modeled results closer matching real operating data
world becomes increasingly urbanized need fresh fruits vegetables urban areas grows difficulty bringing perishable products areas also increases small scale agriculture located urban areas highly effective profitable way provide products communities far extensive commercial agricultural areas describe remote sensing used data mining approaches monitor urban peri urban farms within cities developed developing countries using high resolution satellite imagery together moderate coarse resolution imagery information social media web analyze usefulness different methods identify farms within urban boundaries four countries analysis shows mixed method approach necessary order identify urban farming occurring monitor change time although remote sensing based vegetation water indices useful without ancillary data effective remotely mapping locations urban farms however remote sensing good way monitor vegetation condition locations actively managed urban farms known exist elsevier ltd rights reserved
manufacturing industry facing important challenges terms sustainability flexibility ramp time market shortening pushing rtd towards digital tools methods simulate test production processes hand thus bridging gaps manufacturing engineering production example virtual training offers huge potential reduce time effort traditional hardware training thus leading shorter production ramp time however deployed industrial environment virtual training systems need prove reliability user acceptance purpose study determine impact gaming experience learning process manufacturing operation using virtual simulation training vistra system serious game simulates manufacturing environments order train operators perform manual tasks simulated operations take place welding workstation truck chassis parts automation manual tasks combined case study aims evaluate impact gaming experience general usability vistra system ten operators participated study operator completed five different training scenes three difficulty levels completion time mistake count computed vistra system completing training scene information analyzed compared results showed users without gaming experience took considerably time complete sequences users gaming experience amount mistakes made gamers gamers mistakes made particular scene study thus found gaming experience influences positively training completion time using vistra system particularities mistake count demonstrated gaming experience influence understanding manufacturing operation usability issues found users feedback discussed terms visualization tools parts assisted learning ergonomics authors published elsevier
accuracy repeatability atomic force microscopy afm imaging significantly depend accuracy piezoactuator however nonlinear properties piezoactuators distort image necessitating sensor based closed loop actuators achieve high accuracy afm imaging advent high speed afm made requirements position sensors system even stringent requiring higher bandwidths lower sensor mass traditional sensors provide paper demonstrate way high speed high precision closed loop afm nanopositioning using novel miniaturized micro electromechanical system position sensor conjunction simple pid controller sensor developed respond need small lightweight high bandwidth long range subnm resolution position measurements high speed afm applications demonstrate use sensor closed loop operation conventional well high speed afm operation provide distortion free images presented implementation closed loop approach allows positioning precision angstrom reduces integral nonlinearity allows accurate closed loop imaging line rates
novel generalized perturbation fold darboux transformations dts reported dimensional kadomtsev petviashvili equation extension using taylor expansion darboux matrix generalized perturbation fold dts used find higher order rational solitons rogue wave solutions terms determinants dynamics behaviors rogue waves discussed detail different parameters time display interesting soliton structures including triangle pentagon heptagon profiles etc moreover find new phenomenon parameter control wave structures equation higher order rogue waves equal higher order rational solitons space const results may predict corresponding dynamical phenomena models fluid mechanics physically relevant systems elsevier rights reserved
enormous transmitter power fully programmable antenna array agile frequency generation high frequency active auroral research program haarp facility alaska allowed production unprecedented disturbances ionosphere using pencil beams conical twisted beam transmissions artificial ionization clouds generated near second third fourth sixth harmonics electron gyrofrequency conical beam used sustain clouds opposed less min durations produced using pencil beams largest density plasma clouds produced highest harmonic transmissions satellite radio transmissions mhz national research laboratory tacsat communications experiment severely disturbed propagating artificial plasma regions scintillation levels uhf waves passing artificial ionization clouds haarp typically much larger previously reported scintillations facilities limited less goals future haarp experiments build discoveries sustain plasma densities larger background ionosphere use ionospheric reflectors radio signals
polyols hydrogenated carbohydrates used sugar replacers interest arises multiple potential health benefits non cariogenic sugar free tooth friendly low glycaemic potentially helpful diabetes cardiovascular disease low energy low insulinaemic potentially helpful obesity low digestible potentially helpful colon osmotic colon hydrating laxative purifying carbohydrates potential health benefits reviewed major focus glycaemic index polyols regards health implications low foods literature glycaemia insulinaemia polyol ingestion analysed expressed insulinaemic index modes yielded values erythritol xylitol sorbitol mannitol maltitol isomalt lactitol polyglycitol values much lower sucrose glucose values replacing sucrose independent intake state carbohydrate metabolism normal type artificial pancreas type diabetes mellitus assignment foods polyols bands considered high intermediate low low including non glycaemic last aims target particularly low carbohydrate based foods polyols ranged low low examination made dietary factors affecting polyols foods polyol food values could used estimate food mixtures containing polyols without underestimation among foods polyols departure observed due fat elevating reducing fat exerted additional negative influence presumed due reduced rates gastric emptying among foods examined interaction prominent snack foods potentially damaging insulinaemia could reduced using polyols improved glycated haemoglobin marker glycaemic control found week study type diabetes mellitus patients consuming polyol adding studies showing improved glucose control ingestion low carbohydrate general improvement long term glycaemic control discernible reducing glycaemic load via little daily similar amounts polyols normally acceptable although polyols essential nutrients contribute clinically recognised maintenance healthy colonic environment function role polyols polyol foods hydrate colonic contents aid laxation recognised physicians polyols favour saccharolytic anaerobes aciduric organisms colon purifying colon endotoxic putrefying pathological organisms clinical relevance polyols also contribute towards short chain organic acid formation healthy colonic epithelium polyol tooth friendliness reduced energy values affirmed add potential benefits regard gastrointestinal tolerance food scientists nutritionists physicians dentists independent professional capacities described sensible approaches use consumption polyols
composite tubes used many applications pipes robot arms drive shafts electrical conduits printing rollers tube structures sports equipment rocket structures satellite truss structures landing gears helicopters structural building members etc thin wall tubes made isotropic materials flexural stiffness usually determined using strength material approach expression material modulus cross section inertia composite tubes many layers different orientations involved situation complex comparison results obtained using strength materials equation equation based elasticity shows large difference order sure validity results experimental validation necessary paper presents experimental work done determination flexural stiffness thick composite tubes thick composite tubes manufactured using automated fiber placement machine special test set developed subject tubes pure bending strain gages digital image correlation used determine strains subsequently flexural stiffness experimental flexural stiffnesses tubes determined results compared calculated using different equations elsevier ltd rights reserved
identifying parameters model rating competitive models based measured data among important challenging topics modern science engineering great potential application structural system identification updating development high fidelity models problems principle tackled using bayesian probabilistic approach parameters identified treated uncertain inference information given terms posterior probability distribution complex models encountered applications efficient computational tools robust number uncertain parameters problem required computing posterior statistics generally formulated multi dimensional integral space uncertain parameters subset simulation developed solving reliability problems involving complex systems found robust number uncertain parameters analogy recently established bayesian updating problem reliability problem opens possibility efficient solution subset simulation formulation called bus bayesian updating structural reliability methods based standard rejection principle theoretical correctness efficiency require prudent choice multiplier remained open question paper presents fundamental study multiplier investigates bias effect properly chosen revised formulation bus proposed fundamentally resolves problem subset simulation implemented without knowing multiplier priori automatic stopping condition also provided examples presented illustrate theory applications published elsevier
sampling computational delay necessary digital control though may alter characteristics actual controlled plant considered discrete domain accordingly article establishes mathematical model single phase grid connected inverter lcl filter discrete domain three active damping control delay times graphics graphics analysed considering influences introduced digital control plant range capacitor current feedback coefficient used active damping control derived guarantee controlled plant poles outside unit circle using nyquist diagrams proper proportional resonant controller parameters intuitively determined theoretical analysis verified using matlab laboratory prototype based digital signal processor tmsf
rainwater harvesting could increase resilience ecosystems loess plateau thus ensure sustainability livelihoods depend key component strategies adapting global climate change study used new method quantify rainwater harvesting potential rwhp across whole loess plateau characterize spatial temporal variation last four decades basis variable infiltration capacity model found mean rwhp study region average water layer thickness considerable scope rainwater harvesting across loess plateau whole extent could potentially provide enough water implement grain green project annual average rwhp decreased slightly hurst exponent analysis indicated trend exhibit long term persistence annual rwhp highest southeast loess plateau lowest northwest areas high rwhp values tended clustered around middle reach yellow river areas significant change areas significant decrease rwhp primarily located around upper middle reaches weihe river upper reach jinghe river eastern guanzhong plain qinhe river watershed area around dongsheng quantitative assessments rwhp likely useful guiding development use innovative rainwater harvesting technologies around world could help relieve problems caused water shortages loess plateau simultaneously eliminate major cause soil erosion copyright john wiley sons ltd
robust efficient object tracking algorithm required variety computer vision applications although various modern trackers impressive performance challenges occlusion target scale variation still intractable especially complex scenarios paper proposes robust scale adaptive tracking algorithm predict target scale sequential monte carlo method determine target location correlation filter simultaneously analyzing response map target region completeness target measured peak sidelobe rate psr lower psr likely target occluded strict template update strategy designed accommodate appearance change avoid template corruption occlusion occurs retained scheme allowed tracker refrains drifting away additionally feature integration incorporated guarantee robustness proposed approach experimental results show method outperforms state art trackers terms distance precision overlap precision publicly available dataset
review begins comprehensive history opioid dependence treatment united states focus evidence based treatment model opioid opiate dependent individuals role reward genetic polymorphisms epigenetic modifications lead vulnerability use misuse opiates opioid treat pain reviewed neurochemical mechanisms acute opiate withdrawal opiate opioid reward mechanisms explored goal identifying specific treatment targets alterations functional brain connectivity based neurobiological mechanisms heroin dependence abstinence also reviewed new clinical model alternative merely blocking acute withdrawal symptoms identified dsm proposed genetic diagnosis onset detoxification determine risk stratification identify polymorphic gene targets pharmaceutical nutraceutical interventions followed simultaneous initiation medication assisted therapy mat enable psychological extinction steady pro dopaminergic therapy goal developing dopamine homeostasis recommended objective interventions prevent future relapse treating reward deficiency syndrome rds behaviors eventually make addiction free life possible
purpose sparsity promoting regularizers enable stable recovery highly undersampled magnetic resonance imaging mri promising improve clinical utility challenging applications however lengthy computation time limits clinical use methods especially dynamic mri large corpus spatiotemporal data present holistic framework utilizes balanced sparse model compressive sensing parallel computing reduce computation time cardiac mri recovery methods theory methods propose fast iterative softthresholding method solve resulting regularized least squares problem addition approach utilizes parallel computing environment fully integrated mri acquisition software methodology applied two formulations multichannel mri problem image based recovery space based recovery results using measured mri data show image series frames proposed space based approach achieves mean reconstruction time min fold improvement compared reconstruction time min nonlinear conjugate gradient method proposed image based approach achieves mean reconstruction time conclusion approach utilized achieve fast reconstruction large mri datasets thereby increasing clinical utility reconstruction techniques based compressed sensing international society magnetic resonance medicine
objective explore australian rural food policy coalition acts influence local food environment focusing specifically composition functions processes well food related strategies policy outputs design qualitative case study approach undertaken three sources used triangulate data eleven semi structured depth interviews coalition members analysis thirty seven documents relating coalition observation one coalition meeting data analysed using thematic constant comparison approach community coalition action theory provided theoretical framework interpret findings setting two rural local government areas south eastern coast victoria australia subjects eleven members food policy coalition results five themes emerged data analysis themes described coalition leadership processes membership structure function pool resources food system advocacy focus collaborative cross jurisdictional strategies ability influence policy change conclusions australian case study demonstrates strong leadership small sized core membership focus collaborative strategies food policy coalitions may mechanism positively influence local food environments
background paucity data heart failure incidence among low income minority populations objective investigate incidence post survival race sex among low income adults southeastern united states methods results participants white black men women enrolled sccs southern community cohort study history receiving centers medicare medicaid services incident diagnoses december ascertained using international classification diseases revision codes via linkage centers medicare medicaid services research files participants black women earned mean age years risk factors common hypertension diabetes mellitus myocardial infarction obesity median follow years participants diagnosed age standardized incidence rates person years white women white men black men black women respectively remarkably higher previously reported among cases deaths occurred median follow years men lower survival hazard ratios confidence intervals white men black men black women compared white women conclusions low income population incidence higher race sex groups previously reported cohorts sccs unique resource investigate determinants risk segment population underrepresented existing cohorts
energy important material basis china economic social development green building rule energy saving environmental protection reasonable efficient air conditioning systems arises historic moment compound air conditioning system cacs ground source direct cooling gsdc system water storage tank system wsts applied clod area details presented monitored data shows average operating cost air conditioning year lower chinese yuan therefore cacs system great potentiality demand building energy saving cold areas authors published elsevier ltd
introduction examined stability smoking behaviors factors associated persistent smoking longitudinal study hiv positive gay bisexual men primary relationships methods sample hiv positive men antiretroviral therapy sex partners completed five assessments two years participants completed semi structured interviews assessed smoking status sociodemographic factors relationship dynamics hiv related disease characteristics latent transition analysis estimated amount transition smoking time latent class analysis examined factors associated smoking status across study period results baseline participants reported current smoking hiv positive men remained smoking category time persistent non smokers persistent smokers men whose partners smoked men lower income higher odds persistent smokers whereas older men men identified latino race ethnicity lower odds persistent smokers compared non smokers conclusions despite efforts reduce smoking among people living hiv plwh substantial subset men continued smoke two years study findings suggest primary partners also smoke low income strongest predictors sustained smoking behaviors among hiv positive men additional research needed better understand increase motivation support smoking cessation among plwh primary partners attending socioeconomic status may inhibit access sustained impact existing smoking cessation programs elsevier ltd rights reserved
partisanship increasingly factors behavior americans political nonpolitical situations yet bounds partisan prejudice largely unknown paper systematically evaluate limits partisan prejudice using series five studies situated within typology prejudice find partisan prejudice predicts suppression hostile rhetoric toward one party avoidance members opposition desire preferential treatment one party behaviors may cause incidental indirect harm opposition find even affectively polarizedthose strongest disdain oppositionare likely intentionally harm opposition minimal levels affective polarization
divergence computer architecture landscape resulted different architectures considered mainstream time application algorithm developers dilemma arises one must focus using underlying architectural features extract best performance architectures writing portable code time focus problem graph analytics target application domain paper present abstraction based methodology performance portable graph algorithm design manycore architectures demonstrate approach systematically optimizing algorithms problems breadth first search color propagation strongly connected components use kokkos manycore library programming model prototyping algorithms portable implementation strongly connected components algorithm nvidia tesla faster state art parallel cpu implementation dual socket sandy bridge compute node
new approach energy reclamation mechanical vibrations presented paper conversion mechanical energy electrical energy achieved using piezoelectric materials originality proposed approach based nonlinear treatment voltage delivered piezoelectric insert embedded vibrating structure nonlinear processing induces strong increase power conversion capability piezoelectric insert theoretical principle nonlinear treatment exposed analytical model electrical generator developed results given model compared experimental set experimental results show extracted electrical energy may increased beyond
article addresses emergence lowest low fertility countries primarily southern europe east asia poses question find large differences birth rates across postindustrial societies set macro micro mechanisms identified examined empirically using comparative data seven countries gender generations survey social norms particular social norms related gender roles center analysis mechanism conditions translation intentions behavior societies discourage gender equity private sphere household tend characterized strong breadwinner ideology societies valorization women role household manager mother mirrored valorization men role breadwinner household societies strong norm young man able support family prior getting married becoming parent males prove adequate breadwinners combined changing structural conditions high unemployment rates prolonged periods education increasingly insecure terms employment flexible labor markets norm lead declining birth rates hence norms work mechanism filters effect structural conditions structural constraints fertility limited labor market opportunities young men affect fertility outcomes via mechanism gender role norms
study examined whether substance use disorders sud poverty predicted first time suicide ideation attempt united states national data respondents without prior histories suicide ideation attempt wave nesarc analyzed determine main interactive effects sud poverty first time suicide ideation attempt wave years later adjusted controls poverty aor drug use disorders aor independently increased risk first time suicide ideation attempt wave sud poverty interact differentially increase risk first time suicide ideation attempt prior adjustment controls study reinforces importance sud poverty risk first time suicide ideation attempt public health efforts target messages drug users impoverished highlight increased risk first time suicide
research problem purpose study explore effects national culture medium type first impression bias reduction context job interview performance appraisals research questions evaluators national culture affect first impression bias reduction medium type text multimedia effective reducing first impression bias medium effect reducing first impression bias vary national culture literature review purpose literature review examine current literature areas national culture medium type first impression bias reduction especially communication context researchers reviewed discussions first impression formation national culture theories media richness theory media multimedia type found reduce first impression bias text medium type national culture literature review suggested national culture dimensions collectivism assertiveness uncertainty avoidance could possibly affect first impression bias reduction methodology researchers conducted quantitative experiment students university chinese university majored business related disciplines researchers requested treatment group participants access performance bias cue participants performed initial appraisal manager based denison leadership index participants viewed job interview manager via different media performed appraisal performance appraisal data collected via website researchers used analysis variance analyze data results discussion study found participants national culture reduces first impression bias media identified first impression bias reduction participants significantly greater chinese participants independent media used regardless national culture media users study found users using text medium able reduce first impression bias significantly users using multimedia implications study reduce first impression bias cross cultural settings managers employees must adapt channels effort allocation communication national culture managers researchers must understand national culture important media reducing first impression bias limitations study use student participants absence national culture dimensions measurement study conducted two national cultures future research could use employees participants measure national culture dimensions replicate study various national cultures
breakthroughs permanent magnet synchronous machines latest technologies especially machine design raise importance machines moreover developments materials technology implement development cost effective profitable products electric machines permanent magnet synchronous machines divided two parts according situation slot pole combination integer fractional permanent magnet synchronous machines subject interest due low torque ripple low cogging torque paper lumped parameter method lpm permanent magnet synchronous machine composed stated lumped parameter verified finite element method smc materials used electric machines flux flows according literatures method used analyze smc used machines finite element method takes quite long time thanks lpm analysis used work analysis period become remarkably shorter addition torque back emf permanent magnet synchronous machine calculated developed lpm method prototype tested seen results produced prototype developed algorithm matching properly
influence catio content piezoelectric photoluminescence performance mol doped nbt xct ceramics investigated results show nbt xct ceramic achieves optimized photoluminescence piezoelectric properties bright red emission enhanced piezoelectric response achieved ceramics room temperature furthermore results show photoluminescence performance ceramics enhanced greatly poling present study opens way enhance photoluminescence rare earth doped ferroelectrics elsevier rights reserved
use analog circuits reduce size power consumption channel decoders viterbi decoders active area research recent years however need digital memory store history path elimination decisions viterbi decoder limits potential advantages could offered analog convolutional decoder implementation especially cases use older silicon process technology dictated application hence power reduction benefits offered deep sub micrometer digital designs exploited novel alternative convolutional decoding method allows entirely analog implementation modified feedback decoding algorithm mfda paper describes first integrated realization convolutional decoder employing mfda rate constraint length decoder employs current mode analog signal processing core fabricated cmos process technology occupying area measured results show decoding speeds excess possible virtually loss coding gain total power consumption single supply although hard decision decoder conversion soft decision decoding requires inclusion simple analog delay line shown paper decoder dedicated implantable biotelemetry system also find use low power applications system level coding simulations also presented useful construction larger decoders benefits mfda approach would pronounced
introduction earthquake nepal killed people injured displaced million one year later national workshop organized various nepali stakeholders involved response earthquake workshop provided participants opportunity reflect experiences sought learn lessons disaster methods one hundred thirty five participants took part directly involved earthquake response included representatives ministry health local national government armed forces non governmental organizations health practitioners academics community representatives participants divided seven focus groups based around following topics water sanitation hygiene hospital services health nutrition education shelter policy community facilitated group discussions conducted nepalese key emerging themes presented results participants described range issues encountered specific area expertize also general issues included logistics supply chain challenges leadership coordination difficulties impacts media well cultural beliefs population behaviour post disaster lessons identified included need community involvement stages disaster response preparedness well development local leadership capabilities community resilience disconnect disaster management policy responses observed may result ineffective poorly planned disaster response conclusion finding time opportunity reflect identify lessons disaster response difficult fundamental improving future disaster preparedness nepal earthquake national workshop offered participants space garnered overwhelming sense wanting things better need nepal centric approach need learn lessons past improve disaster management future
background advanced paternal age childbirth associated psychiatric disorders offspring including schizophrenia bipolar disorder autism however studies investigated paternal age relationship eating disorders offspring large population based cohort examined association paternal age offspring eating disorders whether association remains adjustment potential confounders parental education level may related late early selection fatherhood eating disorder incidence method data individuals born sweden extracted swedish population health care registers authors used cox proportional hazards models examine effect paternal age first incidence healthcare recorded anorexia nervosa eating disorders aed occurring models adjusted sex birth order maternal age childbirth maternal paternal covariates including country birth highest education level lifetime psychiatric criminal history results even adjustment covariates including maternal age advanced paternal age associated increased risk younger paternal age decreased risk aed example fully adjusted hazard ratio years years paternal age category confidence interval aed conclusions large population based cohort paternal age childbirth positively associated eating disorders offspring even adjustment potential confounders future research explore potential explanations association including novo mutations paternal germline
study stiffness feedback control system magnetorheological gel smart material variable stiffness proposed toward design tunable vibration absorber adaptively tune time varying disturbance real time pid controller designed track required stiffness gel controlling magnitude target external magnetic field pervading gel paper proposes novel magnetic field generator could produce variable magnetic field low energy consumption performance gel stiffness control validated experiments showed gel absorber system could automatically tuned field minimize vibration primary system
heavily cold drawing pearlitic steel wires widely used aerospace tire cord suspension bridge cable architecture due high strength acceptable level ductility marine steel wires widely applied marine offshore structures enduring effect stress corrosion corrosion performance significant corrosion primary cause structural deterioration marine offshore structures results structural failure leakage product loss environmental pollution loss life merous studies devoted microstructure evolution cementite dissolution induced cold drawing respect effect microstructure evolution performance pearlitic steel views mainly focused mechanical performance little attention paid effect microstructure evolution corrosion behavior pearlitic steel hence still unclear whether cold drawing influences corrosion resistance pearlitic steel work effect microstructure evolution pitting corrosion pearlitic steel investigated electrochemical measurements carried electrochemical impedance spectroscopy potentiodynamic measurement meanwhile corrosion morphology immersion observed standard visual techniques results indicate corrosion resistance cross section decreases increasing strain cold drawing corrosion resistance longitudinal section decreases first stage cold drawing strain epsilon increases second step cold drawing epsilon characterizing distribution pits evolutionary microstructure induced cold drawing grain boundary pearlite colony boundary phase boundary pits inclined initiate propagation sensitive pitting thus decrease corrosion resistance cross section longitudinal section first stage cold drawing epsilon due multiplication interface increases pitting sensibility microstructure electron backscattered scattering detection used quantify content oftexture pearlitic steels different strains result showed improvement corrosion resistance longitudinal section second stage cold drawing epsilon due variation misorientation angle distribution caused formation oftexture
key points exercise training effectively improves vascular skeletal muscle function however effects training may blunted postmenopausal women result loss oestrogens accordingly capacity deliver oxygen active muscles may also impaired postmenopausal women premenopausal recent postmenopausal women exercise training shown improve leg vascular skeletal muscle mitochondrial function interestingly effects pronounced postmenopausal women skeletal muscle oxygen supply utilization similar two groups women findings suggest early postmenopausal phase associated enhanced capacity leg vasculature skeletal muscle mitochondria adapt exercise training ability deliver oxygen match demand active muscles preserved early phase following menopausal transition exercise training leads favourable adaptations within skeletal muscle however effect exercise training may blunted postmenopausal women result loss oestrogens furthermore postmenopausal women may impaired vascular response acute exercise examined haemodynamic response acute exercise matched pre postmenopausal women weeks aerobic high intensity exercise training twenty premenopausal early postmenopausal meansem years final menstrual period women separated yearsof age meansem years years included training leg blood flow delivery uptake lactate release knee extensor exercise similar pre postmenopausal women exercise training reduced leg blood flow delivery uptake lactate release blood pressure heart rate absolute workloads postmenopausal women effects detected premenopausal women quadriceps muscle protein contents mitochondrial complex iii endothelial nitric oxide synthase enos cyclooxygenase cox cox oestrogen related receptor err increased training postmenopausal women whereas levels mitochondrial complex enos cox increased premenopausal women findings demonstrate vascular skeletal muscle mitochondrial adaptations aerobic high intensity exercise training pronounced recent post compared premenopausal women possibly effect enhanced err signalling also hyperaemic response acute exercise appears preserved early postmenopausal phase key points exercise training effectively improves vascular skeletal muscle function however effects training may blunted postmenopausal women result loss oestrogens accordingly capacity deliver oxygen active muscles may also impaired postmenopausal women premenopausal recent postmenopausal women exercise training shown improve leg vascular skeletal muscle mitochondrial function interestingly effects pronounced postmenopausal women skeletal muscle oxygen supply utilization similar two groups women findings suggest early postmenopausal phase associated enhanced capacity leg vasculature skeletal muscle mitochondria adapt exercise training ability deliver oxygen match demand active muscles preserved early phase following menopausal transition
degeneration nigrostriatal dopaminergic system parkinson disease causes motor dysfunction cognitive impairment etiology cognitive deficits remains unclear present study investigated behavioral effects partial lesions nigrostriatal dopamine pathway rats received bilateral infusions either hydroxydopamine ohda vehicle dorsolateral striatum tested spatial procedural learning tasks compared intact rats depleted rats impaired first task learned required egocentric responses intact rats received prior training spatial task impaired learning subsequent body turn task suggesting prior spatial training may compete egocentric learning intact depleted rats spatial discrimination reversal learning switching allocentric egocentric strategies similar groups results suggest loss associated gross motor pathology temporarily impairs egocentric allocentric learning subsequent behavioral flexibility
noise vibration electrical machines major concern changes machine design improve efficiency lead unacceptable vibrations tools predict vibratory acoustic performance design stage need developed improved finite element model developed analyse vibration behaviour permanent magnet synchronous machine lift installation using finite element software abaqus components subsets machine modelled validated experimental modal analysis ema performed modelling issues overcome accurate enough model reached laminated stator formed pack several steel sheets treated orthotropic material windings considered solid orthotropic part well rotor stator end shields assemblies also validated comparing calculated natural frequencies modes shapes obtained ema bearings join rotor assembly stator represented radial springs electromagnetic forces applied order obtain vibration response mechanical model forces obtained magnetic air gap flux density obtained finite element model developed flux vibration response used calculate radiated noise acoustic model virtual lab results given acoustic numerical model compared sound power measurements made anechoic chamber
objective identify emotion associated risk factors suicidality patients somatoform disorders methods sample consecutive patients diagnosed somatoform disorders psychosomatic ambulance bonn university hospital filled several questionnaires including symptom checklist revised version scl toronto alexithymia scale tas state trait anger expression inventory staxi aim compare patients suicide attempts patients without suicide attempts via mancova group scl tas staxi covariates sex age depression borderline personality disorder results lifetime suicide attempts documented patients current active suicidal ideation thoughts death dying patients lifetime suicide attempts showed significantly psychological distress significantly higher alexithymia sum score significantly higher score trait anger state anger stronger tendency express anger conclusion somatoform disorder patients lifetime suicide attempts might greater difficulties identifying describing emotions tendency intensely experience express anger future longitudinal studies investigate possible links difficulties coping anger suicidality improve prophylaxis treatment suicidal behaviour somatoform disorder patients
bistable electroactive polymer new smart material capable large strain rigid rigid actuation rubbery state polymer heated glass transition stable electrically induced actuation obtained strains large electromechanical instability effectively overcome formation interpenetrating polymer networks application refreshable braille display demonstrated
research supervision services like providing study materials enhanced mobile information retrieval algorithms example semantic searching algorithms require user input one two real world concepts systems implement mobile learning approaches like ambient learning use semantic searching algorithms support research supervision services mobile phones however low adoption approaches african universities attributed limited technical limitations mobile devices include mobile phones instance complex interfaces restricted input small screens mobile phones make difficult enter search keywords user hurry attempt address limitations paper describes dynamic heuristics greedy search algorithm automatically generate search keywords algorithm used allow flexible mobile information retrieval typical ambient learning system
objective determine prevalence repeat teenage pregnancy interval first recent repeat pregnancies well evaluate sexual reproductive health characteristics teenagers repeat pregnancies methods prospective observational study undertaken hospital kwazulu natal south africa may september teenagers aged years pregnant recently delivered terminated pregnancy enrolled questionnaire used obtain data results among participants seen first pregnancy repeat pregnancy interval first recent repeat pregnancies months lower repeat pregnancy participants participants previously used contraception stopped within months used emergency contraception participants repeat pregnancy first pregnancy positive hiv status one sexual partner past months partner least years older conclusion high repeat pregnancy rates low contraception use high hiv prevalence among teenagers south africa worrying focused interventions targeting teenagers following first pregnancy need urgently implemented international federation gynecology obstetrics published elsevier ireland ltd rights reserved
subcutaneous vein network plays important roles maintain microcirculation related diagnostic aspects despite developments optical imaging technologies still difficulties deep skin vascular imaging continued hand since hemoglobin concentration human blood key role veins imaging optical manner used wavelength vascular imaging must chosen considering absorption hemoglobin research constructed near infrared nir light source lower absorption hemoglobin optical region obtain vascular image reflectance geometry used next recorded images vascular network analysis calculation width vascular interest complexity selected region implemented comparing modalities observed proposed imaging system great advantages including nonionized radiation moderate penetration depth diameter cost effective algorithmic simplicity analysis
theory research suggests individuals greater social capital resources benefits gained relationships experiences social interactions may likely active prosocial bystanders bullying situations therefore goal current study examine association social capital social support social skills prosocial bystander behavior role internalizing problems potential barrier relation among students girls white sixth seventh eighth grades results indicate positive relation social capital prosocial bystander behavior addition internalizing problems significant risk factor may hinder youth particularly girls engaging defending behavior prosocial bystanders essential component prevent reduce bullying research needed better understand foster prosocial behavior bullying situations perhaps utilizing social capital related school bullying
objective clinical experience suggests growing prevalence borderline personality disorder aged residential care psychiatric facilities attendant difficulties management paper reviews literature concerning prevalence phenomenology diagnosis borderline personality disorder old age aim elucidate phenomenological differences old age thus improve identification disorder methods systematic search conducted using medline pubmed embase psycinfo databases employing search terms including personality disorder borderline personality disorder aged care gerontology geriatric psychiatry life span search included articles english involving participants years long term prospective studies borderline personality disorder long term follow studies studies involving older adults years also examined results paucity literature borderline personality disorder elderly diagnostic rating instruments developed borderline personality disorder elderly phenomenology borderline personality disorder aged population differs several respects seen younger adults causing difficulties reaching diagnosis escalations symptoms maladaptive behaviours usually occur diagnosis borderline personality disorder either made delayed improved identification borderline personality disorder older patients together staff education concerning phenomenology aetiology management patients urgently needed conclusion diagnostic instruments borderline personality disorder elderly need developed interim suggestions offered concerning patient symptoms behaviours could trigger psychiatric assessment advice concerning management screening tool proposed assist timely diagnosis borderline personality disorder older people timely identification patients needed receive skilled help understanding treatment needed alleviate suffering twilight lives
nutrition essential component promoting health quality life older adults years purpose qualitative research explore rural food environment influences food choices older adults four focus groups conducted older adults years age older residing rural montana communities four major themes related factors influencing food choices among rural older adults emerged study perception rural community environment support means increasing food access personal access food sources dietary factors findings current study warrant research promotion specifically tailored approaches influence food choices older adults rural western usa including developing expanding public transportation systems increasing availability local grocers quality affordable food options increasing awareness decreasing stigma surrounding community food programs increasing nutrition education targeting senior health issues
nickel base superalloy residual stress foundational engineering problem fep program funded united states air force metals affordability initiative mai address bulk residual stresses nickel base superalloy engine disk components stresses induced various manufacturing stages heat treatment process forging process bulk residual stresses problem result component distortion machining process elevated temperature service bulk residual stresses aeroengine disks components considered foundational engineering problem affects suppliers original equipment manufacturers oems issue must addressed cross functional team fep addresses problem developing infrastructure tools needed predict incorporate bulk residual stress design development turbine disk fep answers challenge given report issued national research council authors commented addressing feps essential means help establish infrastructure needed make integrated computational materials engineering icme reality paper report key aspect icme infrastructure namely infrastructure needed manage physical model data addition discussing infrastructure developed paper document lessons learned applied icme community whole
field affective clinical science expanded dramatically past several decades rottenberg gross tracy important part research understanding emotion regulation dysregulation particular individuals differ ability identify accept manage emotional experiences one common widely cited measures emotion dysregulation difficulties emotion regulation scale ders gratz roemer extensively used facilitate understanding emotion dysregulation associated psychiatric symptoms emotion related constructs treatment progress scale contributed greatly understanding emotion regulation problems length makes inclusion brief study protocols difficult limiting utility increasing participant burden order address issue developed short form version ders ders composed strongest items measure six subscales original ders publication gratz roemer validated measure five datasets vary age sample type results demonstrate item short form ders exhibits similar structure original item ders demonstrates excellent reliability validity performs similarly original ders despite comprising half items ders potential improve expand emotion regulation assessment reducing demands research participants
light falling retina converted electrical signal stimulates serotonin synthesis previous studies described increase plasma cns serotonin levels bright light exposure ghrelin leptin peptide hormones involved regulation hunger satiety related serotonin neopterin kynurenine immunological markers also linked serotonin biosynthesis study healthy male volunteers exposed bright dim light conditions min cross manner subjective well hunger well various serotonin associated plasma factors assessed light exposure subjective well showed small increase bright light small decrease dim light resulting significant interaction light condition time ghrelin concentrations increased significantly light conditions interaction light time correspondingly leptin decreased significantly light conditions hunger increased significantly light time interaction also found significant decrease neopterin tryptophan tyrosine levels interaction light time conclusion ambient light affecting subjective well rather serotonin associated biological factors published elsevier ireland ltd
background efficacy exercise therapy ankylosing spondylitis well documented dearth information non radiographic axial spondyloarthritis axspa biomarkers like serum calprotectin interleukins tumour necrosis factor tnf alpha may reflect disease activity axial spondyloarthritis axspa study investigated clinical laboratory parameters axspa subgroups response intensive physical exercise methods altogether patients axspa characterised according assessment spondyloarthritis international society criteria axspa underwent month exercise programme clinical outcomes disease activity bath disease activity index basdai disease activity index asdas crp mobility bath metrology index basmi function bath functional index basfi evaluated baseline end exercise programme serum tnf alpha calprotectin measured via elisa clinical laboratory data control axspa patients used evaluation results results axspa patients asdas crp basmi improved months exercise therapy significant improvement asdas crp axspa subgroup basmi axspa subgroups respectively asdas crp basdai significantly improved exercise axspa group compared control axspa group mean respectively calprotectin significantly reduced exercise programme axspa patients respectively change calprotectin profound axspa intervention group mean control axspa mean conclusion study demonstrated similar efficacy intensive exercise programme axspa patients significant decrease serum calprotectin levels subgroups axspa patients exercise programme reflected improvement disease activity spinal mobility
background universal screening pregnant women postpartum depression recently recommended however optimal application depression screening tools stratifying risk defined current study examines new approaches improve ability edinburgh postnatal depression scale epds stratify risk postpartum depression including alternate cut points use continuous measure incorporation putative risk factors methods observational cohort study women screened antepartum postpartum negative epds screen antepartum epds primary outcome probable postpartum major depressive episode epds cut area receiver operating characteristics curve auc sensitivity specificity predictive values calculated results women screened positive postpartum depression antepartum epds cut antepartum epds cut values discrimination improved auc ranging antepartum epds combined prior history major depressive disorder pregnancy limitations inability assess epds subscales relatively low prevalence depression cohort conclusions though antepartum epds cut score yielded greatest discrimination identifying women low risk postpartum depression negative predictive value insufficient substitute postpartum screening
study aims investigate influence different neck structures implant stress distribution computer aided design cad mandibular model based adult mandibular computed tomography information first established used create mandibular model related mandibular implant model using solidworks implant fitted mandibular first molar four neck type implants uniform threaded implant wide neck implant implant single microthreaded neck smn implant double microthreaded neck dmn received axial horizontal oblique loads using ansys workbench software von mises equivalent stress maximum principal stress mps different implant groups compared axial load maximum cortical bone area mes mpa smn dmn respectively mps superior edge cortical bone mps mpa four groups respectively horizontal load mes smn dmn respectively mps four groups respectively oblique load mes smn dmn respectively mps four groups respectively mes mps smn smallest
animal studies suggest methyl aspartate receptor nmdar dependent signalling limbic prefrontal regions critically involved cognitive emotional functions humans ketamine induced transient disorder associated chronic nmdar hypofunction schizophrenia associated deficient performance domains memory higher order emotional functioning well altered neural activity underlying limbic prefrontal circuits model effects nmdar hypofunction integration emotion cognition present pharmacological fmri study applied nmdar antagonist ketamine target plasma level healthy volunteers within subject placebo controlled crossover design encoding neutral positive negative pictures results show irrespective emotion ketamine suppressed parahippocampal medial prefrontal activity contrast ketamine selectively increased amygdala orbitofrontal activity successful encoding negative stimuli network level ketamine generally increased medial prefrontal parahippocampal coupling specifically decreasing amygdala orbitofrontal interplay encoding negative stimuli behavioural level ketamine produced generally decreased memory performance abolished emotional enhancement memory wash period days present findings suggest ketamine produces general well valence specific effects emotional memory formation pattern partly overlaps alterations previously observed patients schizophrenia
decisions use psychotropic medication pregnancy ongoing challenge clinicians women mental health problems owing uncertainties around risks illness mother fetus infant effectiveness medications pregnancy risks fetus infant utero exposure via breast milk consensus guidelines aim provide pragmatic advice regarding issues divided sections risks untreated illness pregnancy general principles using drugs perinatal period benefits harms associated individual drugs recommendations management specific disorders
based logical ghz states logical bell states two robust quantum key agreement protocols proposed immune collective dephasing noise collective rotation noise respectively delayed measurement technique ensures two participants fairly negotiate shared key one successfully perform participant attacks two protocols congenitally free trojan horse attacks resist outsider attacks help decoy state technology moreover information leakage problem achieve high qubit efficiency
image encryption attractive research field recent years chaos based cryptographic algorithms suggested new efficient ways develop secure image encryption techniques paper proposes novel image encryption scheme based chaotic tent map image encryption systems based map show better performances firstly chaotic tent map modified generate chaotic key stream suitable image encryption secondly chaos based key stream generated chaotic tent map better performance terms randomness properties security level performance security analysis proposed image encryption scheme performed using well known ways results fail safe analysis inspiring concluded proposed scheme efficient secure
objective medical school student attends appears factor whether students eventually match psychiatry knowledge factors associated medical schools higher recruitment rates psychiatry may assist developing strategies increase recruitment methods psychiatry leaders medical student education highest lowest recruiting allopathic schools surveyed concerning various factors could important curriculum educational leadership presence anti psychiatry stigma relationship survey results high recruiting schools versus low recruiting schools evaluated using mann whitney tests results factors significantly associated higher recruiting schools included better reputation psychiatry department residents perceived higher respect psychiatry among non psychiatry faculty less perception students dissuaded students pursuing psychiatry longer clerkship length conclusions educational culture climate factors may significant impact psychiatry recruitment rates clerkship length associated higher recruiting schools several previous studies complete samples shown
introduction seems pursuit muscularity may related eating disorders male athletes however knowledge studies topic objective aim study analyze relationship pursuit muscularity mood state eating disorders population methods study included athletes various sporting modalities federations southeastern brazil used eating attitudes test eat drive muscularity scale dfm brunel mood scale brums evaluate respectively eating behaviors risk pursuit muscularity mood state results findings hierarchical regression models show relationship pursuit muscularity mood state disordered eating however results indicated difference pursuit muscularity according eat classifications conclusion concluded mood state pursuit muscularity related eating disorders male athletes
globally marine protected areas mpas relatively unsuccessful meeting biodiversity objectives effective require alteration people use access marine resources resist perceive associated benefits stakeholders support crucial ecological success mpas support likely depend capacity adapt benefit mpas examined influence social adaptive capacity sac perceived benefits mpas siquijor philippines coral triangle region substantial biodiversity population million people many dependent marine resources food income region many mpas managed decentralized governance systems collected survey data households villages associated mpas evaluated influence multiple sac variables occupational multiplicity social capital perceived benefits decision trees chaid qualitatively analyzed relationship respect types recipients benefits models revealed key role social capital particularly trust leadership influencing perceptions benefits path analysis revealed perceptions distributional equity key mechanism social capital affected perceived mpa benefits root mean square error approximation building social capital equity within communities could lead effective management mpas thus expenditure fewer resources relative example regulation enforcement
objectives due enhanced life expectancy increasing elderly population sexual physical problems related menopause essential health point view study performed evaluate effect ginkgo biloba tablet aromatherapy inhaler combination lavender fennel geranium rose decrement sexual dysfunction postmenopausal women materials methods double blind randomized clinical trial performed postmenopausal women age range years referring health care centers ardabil university medical sciences iran participants randomly divided groups subjects ginkgo biloba tablet placebo aroma solution users aroma solution placebo ginkgo biloba users placebo aroma placebo ginkgo biloba users received ginkgo biloba either tablet placebo drops aroma solution placebo skin times day weeks tool collecting data questionnaire encompassed questions socio demographical features female sexual function index fsfi primary outcome sexual function mean score intervention research groups analysis conducted according intention treat results mean scores total sexual function baseline aromatherapy ginkgo biloba placebo groups enhanced mentioned groups respectively intervention analysis covariance ancova test indicated significant discrepancy intervention total sub domains scores sexual function exception pain ginkgo biloba aromatherapy groups compared placebo controlling confounding factors conclusion aromatherapy inhaler combination ginkgo biloba tablet improved sexual function postmenopausal women
prospectively evaluate feasibility diagnostic performance gauge helical tip spirotome cook medical bloomington usa needle transthoracic needle biopsy ttnb lung lesions compared conventional gauge tru cut needle study institutional review board approved informed consent obtained data synchronous spirotome tru cut image guided ttnb consecutive patients malignant peripheral lung tumors larger enrolled pathologic characterization mutational analysis samples obtained spirotome tru cut needle compared fragmentation length weight morphologic immunohistochemistry typifying tumor cellularity dna concentration technical success rate ttnb spirotome major complications occurred less fragmentation mean fragments greater weight mean lower length mean observed spirotome compared tru cut needle accuracy spirotome tru cut needle defining cancer histotype similar absolute relative mean hpf dna concentration mean higher spirotome compared tru cut needle statistical significance respectively percutaneous gauge spirotome ttnb selected lesions feasible accurate provides adequate samples diagnosis comparable gauge tru cut needle higher amount tumor tissue weight dna concentration even shorter samples
today manufacturing shaped paradigm shift mass production demand dictated personalized customer driven knowledge based proactive production thus shorter product life cycles increased number product varieties high performance processes flexible machines production systems result increased complexity factory level domains product design process development factory production planning factory operation handle complexity new knowledge based methods technologies tools model simulate optimize monitor planned existing manufacturing systems required paper presents challenges approach overview results funded project appsame provides concise overview engineering apps eapps approach project based project aims comprehensive consideration ict based support manufacturing engineering mentioned domains called advanced manufacturing engineering ame different life cycles aligned development reference data model provides detailed overview relevant domain specific inter domain interdependencies life cycle oriented model enables integrated product design process development factory planning well production planning factory operation stakeholders activities supported eapps conceived developed validated help four industrial use cases spanning diverse industrial branches authors published elsevier
propose concept autonomous self damaging smart composite materials controlled activation added nanosize damaging capsules percolation type modeling approach earlier applied related concept self healing materials used investigate behavior initial material fatigue aim achieving relatively sharp drop material integrity initial limited fatigue develops course sample usage theoretical study considers two dimensional lattice model involves monte carlo simulations connectivity conductance high connectivity regime percolation give several examples local capsule lattice capsule capsule activation rules show desired self damaging property obtained rather sophisticated smart material response involving damaging also healing capsules elsevier rights reserved
depressed patients often show altered circadian rhythms sleep disturbances diurnal mood variation decreased latency rapid eye movement rem sleep reduction slow wave sleep abnormalities timing rem nonrem sleep cycles reported patients major depressive disorder mdd thus evident understanding basic mechanisms sleep regulation essential better analysis pathophysiology depressive disorders aim article review progress understanding mechanisms underlie circadian sleep rhythms role treatment depression chronotherapies including bright light exposure sleep deprivation melatonin treatment social rhythm therapies may provide novel insights development new pharmacological behavioral treatment strategies mood disorders novel antidepressant agomelatine combines properties serotonin htc antagonist melatonergic receptor agonist found effective resetting disturbed sleep wake cycle improving clinical status depressed patients agomelatine may fill gap current therapeutic armoury combining tolerability profile efficacy treating mdd
research domain criteria rdoc address three types aggression frustrative non reward defensive aggression offensive proactive aggression review sought present evidence genetic underpinnings aggression determine degree prior studies examined phenotypes fit rdoc framework although constructs defensive offensive aggression widely used animal genetics literature human literature mostly agnostic regard rdoc constructs know twin studies half variance behavior may explained genetic risk factors true dimensional trait like measures aggression categorical definitions psychopathology non shared environment seems moderate influence effects shared environment unclear human molecular genetic studies aggression early stage promising candidates dopaminergic serotonergic systems along hormonal regulators genome wide association studies yet achieved genome wide significance current samples small detect variants small effects one would expect complex disorder strongest molecular evidence genetic basis aggression comes animal models comparing aggressive non aggressive strains documenting effects gene knockouts although learned much prior studies future studies improve measurement aggression using systematic method measurement proposed rdoc initiative wiley periodicals inc
objective study aimed determine prevalence subclinical enthesopathy patients psoriasis using power doppler ultrasonography pdus association disease parameters material methods total patients psoriasis females aged years underwent thorough clinical examination included assessment body mass index bmi psoriasis area severity index pasi score measurements inflammatory markers reactive protein crp erythrocyte sedimentation rate esr serum uric acid plain radiography heels knees sacroiliac joints performed patients patients without clinical evidence arthritis enthesitis underwent ultrasonographic examination according examination patients classified group patients enthesitis group patients without enthesitis results group achilles enthesis common site enthesitis followed distal patellar enthesis proximal patellar enthesis quadriceps enthesis plantar aponeurosis enthesis statistically significant positive correlation occurrence enthesitis patient age disease duration pasi score bmi hyperuricemia conclusion addition importance pdus complimentary tool examining enthesis patients psoriasis presence high pasi score increased bmi hyperuricemia long disease duration considered predictive parameters presence psoriatic enthesitis
study examined associations psychopathy facets boldness meanness disinhibition clinically relevant variables physiological reactivity affective stimuli associations examined accounting developmental associations adolescent psychopathic traits namely callous unemotional traits narcissism impulsivity psychopathic traits assessed adolescence using antisocial process screening device inventory callous unemotional traits young adulthood via triarchic psychopathy measure clinical variables age female well affective physiological responses heart rate skin conductance startle modulation violent erotic videos mage female also assessed adulthood accounting adolescent psychopathic traits boldness associated high cognitive reappraisal low anxiety fear hostility meanness related callous unemotional traits hostility less sympathy victims less use cognitive reappraisal disinhibition contrast associated impulsivity increased anxiety hostile aggressive tendencies well conduct disorder antisocial personality disorder symptoms cognitive suppression addition evidence found different physiological measures operating biological indicators distinctive dimensions reduced resting heart rate cardiac reactivity violent stimuli indicative boldness beyond adolescent psychopathic traits low startle potentiation violent stimuli indicative callous unemotional traits meanness findings provide evidence value multidomain approach clarifying neurobiological mechanisms psychopathic tendencies inform prevention treatment efforts
cytotoxic chemotherapy cornerstone medical therapy gastrointestinal cancers better understanding molecular biology cancer cell led therapeutic revolution targeted therapies monoclonal antibodies small molecule inhibitors directed proteins specifically overexpressed ormutated cancer cells agents specific cancer cells expected less toxic cytotoxic agents targeted agents provided clinical benefit many cancer types example antiangiogenics anti egfr therapies significantly improved survival patients affected metastatic colorectal cancer deeply changed therapeutic strategy disease however effects sometimes disappointing due intrinsic acquired resistance mechanisms ras mutation anti egfr therapies activity restricted tumour settings lack activity cancer types microscopic residual disease adjuvant setting many studies negative overall population positive specific patient subgroups trastuzumab positive gastric cancer illustrating importance patient selection early identification predictive biomarkers response therapies propose comprehensive two part review providing panoramic approach successes failures targeted agents cancers unravel pharmacologic opportunities future directions agents oncology first part focus adenocarcinomas squamous cell carcinomas targeted therapies mostly used combination chemotherapy elsevier inc rights reserved
aim research assess implicit processing social non social distracting cues children adhd young people adhd matched controls asked classify target words left right accompanied distracter eye gaze arrow typically developing participants showed evidence interference effects eye gaze arrow distracters contrast adhd group showed evidence interference effects arrow failed show interference eye gaze absence interference effects eye gaze observed participants adhd may reflect attentional impairment attending socially relevant information
paper presents optimal method tune proportional integral derivative pid controller hydraulic turbine coupled corresponding transient droop compensator tdc proposed methodology based desired time response specification dtrs input guide vane servomotor includes typical rate limiters gain saturation power plants therefore problem consists adjusting parameters controller compensator time response remains close specified one avoid suboptimal solutions local minimum points necessary solve resulting non linear problem two steps firstly solve linear programming determine values pid tdc block using state space representation match input output time responses specifications determine final values pid tdc parameters using previous results new non linear programming proposed methodology presented advantage tuning pid coordinated tdc spending low computational time results show performance method covers wide range operating conditions system comparisons also made existing methods literature show effectiveness proposed methodology elsevier ltd rights reserved
introduction sphenoid sinus often neglected difficult access deep position sphenoid sinus hinders early diagnosis pathologies location delayed diagnosis cause serious complications due proximity many important structures objectives aim study demonstrate different pathologies affect sphenoid sinus elucidate findings methods cases isolated sphenoid sinus lesions encountered neurosurgical setting rare pathologies discussed pathologies langerhans cell histiocytosis solitary plasmacytoma chordoma pituitary adenoma leiomyosarcoma fungal infection mucocele appeared primarily sphenoid sinus discussed along imaging features pathological findings conclusion multitude different pathologies occur sphenoid sinus detailed preoperative imaging helpful transnasal biopsy histological study required often definitive diagnosis possible advantages early diagnosis spread pathology prognosis overemphasized
hyperspectral sensors describe plant canopy reflectance greater detail multispectral sensors also suffer issues data redundancy spectral autocorrelation data mining techniques extract relevant spectral features hyperspectral data aid development novel sensors plant trait estimation objectives research compare broad band reflectance narrow band reflectance spectral derivatives estimation durum wheat traits field develop genetic algorithm identify relevant spectral features durum wheat trait estimation experiments maricopa arizona winters tested six durum wheat cultivars six split applied nitrogen fertilization rates durum wheat traits including leaf area index canopy dry weight plant content measured destructive biomass samples four occassions growing season grain yield grain content also measured canopy spectral reflectance data narrow wavebands collected weekly using field spectroradiometer first second order spectral derivatives calculated using savitzky golay filtering narrow band data also used estimate reflectance broad wavebands typically collected two commercial multispectral instruments partial least squares regression plsr compared ability spectral data set estimate measured durum wheat trait genetic algorithm developed mine narrow band canopy reflectance spectral derivative data spectral features improved estimates durum wheat traits multispectral data broad bands estimated leaf area index canopy dry weight plant content root mean squared errors cross validation rmsecv hyperspectral data narrow bands reduced rmsecv values use genetic algorithm identify less relevant spectral features reduced rmsecv values grain yield optimally estimated canopy spectral measurements days planting rmsecv less using genetic algorithm approach timing corresponded anthesis early grain fill presence wheat heads likely affected canopy spectral reflectance using genetic algorithm mine hyperspectral reflectance spectral derivative data durum wheat traits optimally estimated subset relevant canopy spectral features published elsevier
due formal protection commercial development cultural ecology cultural forms vernacular architecture landscape local characteristics threatened seriously however present records vernacular architecture landscape protection lack support new high technology three dimensional panoramic hybrid technology blend virtual objects accurately real environment computer graphics computer vision technology technique provides effective way express stereoscopic three dimensional real scene research three dimensional panoramic hybrid technology reasonably applied implementation strategy process vernacular architecture landscape protection make inadequacy application field vernacular architecture heritage protection extend application information technology based dimensional digitalization architecture heritage protection time
schema therapy dialectical behavior therapy dbt shown effective treatment methods especially borderline personality disorder dbt roots cognitive behavioral therapy aim helping patient deal emotional dysregulation however major differences terminology explanatory models techniques used methods article gives overview major therapeutic techniques used dbt respect emotion regulation systematically puts context james gross process model emotion regulation similarities differences two methods highlighted illustrated case example core difference two approaches dbt directly focusses acquisition emotion regulation skills whereas seldom address emotion regulation directly dbt modules mindfulness distress tolerance emotion regulation interpersonal effectiveness intended improve emotion regulation skills patients encouraged train skills regular basis dbt assumes improved skills skills use result better emotion regulation problems emotion regulation seen consequence adverse early experiences lack safe attachment childhood abuse emotional neglect negative experiences led unprocessed psychological traumas fear emotions result attempts avoid emotions dysfunctional meta cognitive schemas meaning emotions assumes underlying problems addressed emotion regulation improves major techniques trauma processing emotional avoidance dysregulation limited reparenting empathic confrontation experiential techniques like chair dialogs imagery rescripting
paper seeks contribute green building debate economics management focusing environmental innovation innovation leadership latter dynamic capability innovative firm seize new innovation opportunities result proactive investment policy enhanced innovativeness paper defends thesis according firms consistently innovation leaders encourage environmental innovations use french cis surveys employ heckman selection estimation method using sample firms study different forms innovation leadership increase propensity develop environmental innovations find strong impact innovation leadership measured novel way using innovation persistence furthermore results show strong impact regulations costs savings determinants eco innovation elsevier inc rights reserved
due grave situation china water environment aquatic ecosystems prime importance understand present situation china water resources vulnerability situation evolved recent past consequently performed comprehensive spatio temporal analysis china water resources vulnerability period using composite index approach array aspects highlighting key challenges china water resources system facing water resources northern central coasts appeared vulnerable western china china water productivity grown substantially study period safe drinking water improved sanitation accessibility contrast water pollution worsening remarkably parts china water scarcity shortage stressed parts country elsevier ltd rights reserved
primary objective present paper increase standard oxygen transfer efficiency sote aeration tank achieve without increasing power required pump air aeration tanks mixer turbine blades added regular fine bubble aeration diffuser turbine blade extracts power moving water current transfers power mixer top diffuser support structure mounted air connect turbine blade mixer one shaft furthermore electrical generator connected shaft extract surplus energy system high flow rates results showed mixer powered turbine blade extracted power induce less oxygenated water core bubble column without using additional energy thus system lead efficient distribution oxygen within water tank furthermore found turbine blade captured energy needed mixer excess energy collected using electrical generator results showed self powered mixer increase sote time power used air pumping reclaimed using electrical generator high flow rates jordan journal mechanical industrial engineering rights reserved
present study method slurry coating process used fabricate functionally graded thermal barrier coating tbc turbocharger application automatic film applicator used coating attempt minimize production cost ceramic thermal barrier coatings yttria stabilized zirconia ceramic nickel metal powders mixed appropriate proportion produced functionally graded material mixture slurry based coating method used fabrication tbc coating compositions yttria stabilized zirconia nickel yttria stabilized zirconia nickel well yttria stabilized zirconia nickel used depositing first second third layers functionally graded thermal barrier coating substrate respectively field emission scanning electron microscopy scanning electron microscope ray diffraction used study evaluate integrity reliability coating produced results indicated sustainability suitability method adopted study regards production good quality functionally graded thermal barrier coating spallation problem good adherence substrate elsevier ltd rights reserved
discriminant analysis method used differentiate classify water quality three major rivers south florida study used assess water quality evaluate spatial temporal variations surface water quality south florida important data reduction method used assess water pollution status analysis spatiotemporal variation found stepwise five variables chl dissolved oxygen total kjeldahl nitrogen tkn total phosphorus water temperature important discriminating water quality parameters responsible temporal variations spatial variation water quality also evaluated identified five variables tkn ammonia magnesium sodium seven variables chl tkn ammonia magnesium chloride significant discriminating variables wet dry season respectively three selected rivers south florida believed results apportionment could useful local authorities control management pollution better protection important riverine water quality
objective pkip one negative regulators cell cycle plays important role regulating cell cycle inhibiting cell proliferation restraining cell phase pkip downregulation maybe related occurrence oral squamous cell carcinoma oscc found mir significantly upregulated oscc tissue bioinformatics analysis revealed mir may bind utr pkip study investigated role mir regulating pkip affecting tca cell proliferation cycle apoptosis patients methods total cases oscc patients received treatment hospital enrolled obtain tumor tissue another normal oral mucosa samples selected control detect relationship mir pkip expressions dual luciferase assay adopted confirm targeted relationship mir pkip flow cytometry applied test cell apoptosis cell cycle cck assay used evaluate cell proliferation caspase activity detected spectrophotometry results mir upregulated pkip declined oscc tissue compared normal oral mucosa expressions related tnm stage mir targeted suppressed pkip expression mir mimic pegfp pkip transfection obviously declined pkip expression blocked cell cycle phase reduced cell proliferation enhanced caspase activity increased cell apoptosis tca cells conclusions mir increased pkip reduced oscc tissue inhibition mir upregulated pkip expression blocked cell cycle phase weakened cell proliferation induced cell apoptosis
ecological impacts invasive plants increase dramatically time since invasion targeting young populations treatment therefore economically ecologically effective management approach especially linked post treatment monitoring evaluate efficacy management however collecting detailed field based post treatment data prohibitively expensive typically resulting inadequate documentation ecological effects invasive plant management alternative approaches remote detection unmanned aerial vehicles uav provide opportunity advance science practice restoration ecology study sought determine plant community response different mechanical removal treatments dominant invasive wetland macrophyte typha spp along age gradient within great lakes coastal wetland assessed post treatment responses intensive field vegetation uav data prior treatment oldest typha stands lowest plant diversity lowest native sedge carex spp cover greatest typha cover following treatment plots mechanically harvested surface water differed unharvested control water harvested plots several plant community measures including lower typha dominance lower native plant cover greater floating submerged aquatic species cover repeated measures analysis revealed water cutting increased plant diversity aquatic species cover across ages maintained native carex spp cover youngest portions typha stands uav data revealed significant post treatment differences normalized difference vegetation index ndvi scores blue band reflectance vegetation height remotely collected measures corresponded field observations findings suggest mechanically harvesting water biomass young typha stands harvesting older stands water promote overall native community resilience increase abundance floating submerged aquatic plant guilds vulnerable invasions large macrophytes uav provided fast spatially expansive data compared field monitoring effectively measured plant community structural responses different treatments study results suggest pairing uav flights targeted field data collection maximize quality post restoration vegetation monitoring
increasing research efforts exploring racial ethnic composition population served child welfare system cws however limited research examined unique experiences cws involved latino latina children families particularly reported child sexual abuse csa lack research troubling given latinos latinas country largest fastest growing minority group address knowledge gap secondary data analysis uses data national child abuse neglect data system child file examine sample children reported cws subsample children involved csa reports using descriptive bivariate analyses describe national profile cws involved latino latina children reported csa profile developed based child characteristics analytic sample rates case substantiation report sources perpetrator characteristics caretaker risk factors compare profile subgroup latino latina children profiles children non latino latina black non latino latina white results indicate several significant differences exist profiles cws involved latino latina children csa report compared counterparts racial ethnic groups findings discussed aim informing practice policy research sexual abuse prevention intervention strategies latino latina populations elsevier ltd rights reserved
ecological momentary assessment ema group research methods collect data frequently many contexts real world settings ema fairly neglected suicidology current article provides overview ema suicidologists including definitions data collection considerations different sampling strategies next benefits ema suicidology reduced recall bias accurate tracking fluctuating variables testing assumptions theories use interventions participant safety considerations examples published research investigate self directed violence variables using ema discussed article concludes summary suggested directions ema research suicidology particular aim spur increased use methodology among suicidologists
inflammatory bowel diseases ibd including ulcerative colitis crohn disease involve inappropriate immune reaction digestive tract causing variety disabling symptoms advent monoclonal antibodies anti tumor necrosis factor anti integrin anti interleukin revolutionized ibd management nevertheless agents potential immunogenicity associated high rates response loss disease relapse time also associated high production costs sphingosine phosphate membrane derived lysophospholipid signaling molecule implicated vast array physiological pathophysiological processes primarily via extracellular activation receptors involved regulation immune system may associated cardiovascular pulmonary theoretical cancer related risks targeting receptors inflammatory conditions successful clinical trials leading approval non selective modulator fingolimod relapsing forms multiple sclerosis however association non selective modulator serious adverse events provides rationale developing selective receptor modulators recently three modulators differing selectivity receptors clinical development ibd ozanimod rpc etrasimod apd amiselimod development amiselimod stopped biogen currently focusing drugs portfolio following encouraging results fromthe phase touchstone trial phase trial spmodulator ozanimod patientswith moderate severe ulcerative colitis ongoing etrasimod also tested phase trial ulcerative colitis pipelinemedications administered orally may avoid formation anti drug antibodies lead treatment failure injectable biologic therapies ibd data ongoing clinical trials establish relationship selectivity modulators safety efficacy ibd well potential place clinical armamentarium ibd published elsevier
introduction although several methods developed alleviate stress among college students logistic limitations adopting limited utility aim hence aimed test practical approach alleviate stress among college students achieving vestibular stimulation using swings materials methods study male female participants randomly assigned vestibular stimulation control groups depression anxiety stress scores sleep quality heart rate blood pressure autonomic functions respiratory haematological cognitive function quality life recorded days vestibular stimulation results stais stait scores significantly improved day following vestibular stimulation diastolic mean arterial blood pressure significantly decreased remained within normal limits vestibular group day following vestibular stimulation postural fall blood pressure significantly improved day onwards following vestibular stimulation respiratory rate significantly improved day onwards following vestibular stimulation psqi sleep disturbance psqi sleep latency psqi total score bleeding time significantly improved following vestibular stimulation conclusion study supports adoption vestibular stimulation stress management hence placement swings college campuses must considered may simple approach alleviate stress among college students
work studied parameters affecting localization hydrophobic nanosilica particles impact morphology development polyethylene polystyrene poly methyl methacrylate hdpe pmma ternary blends originally thermodynamically preferred core shell type morphology means combination rheology electron microscopy attempt also made compare experimental results thermodynamic predictions ternary blend samples blend ratio varying nanosilica loadings prepared melt compounding using laboratory internal mixer demonstrated nanosilica localization could controlled sequence feeding would play significant role determining morphology development nanofilled ternary blend samples shown contrary thermodynamic prediction core shell morphology nanofilled samples highly enhanced melt elasticity nanosilica filled polystyrene phase allow phase form complete encapsulating shell
work presents new discrete time adaptive predictive control algorithm system force disturbance input delay scenario representative mechatronic device percutaneous intervention pneumatic actuation long supply lines controlled remotely presence unknown external force resulting needle tissue interaction gravity ultimate goal research robotic assisted percutaneous intervention liver magnetic resonance imaging mri guidance since control algorithm intended digital microcontroller presented discrete time form controller design illustrated degree freedom system conducted modular approach combining position control adaptive disturbance compensation predictive control controller stability analyzed effect input delay tuning parameters discussed controller performance assessed simulations considering disturbance representative needle insertion forces results indicate adaptive predictive controller effective presence variable disturbance known variable input delay
secondary data analysis mothers children investigated racial disparities children health associations social structural factors social relationships support health mental health substance use access health mental health services study drew longitudinal records mother child pairs created data fragile families child wellbeing study generalized estimating equations yielded results showing children good health associated positively mother health current health health pregnancy across three ethnic groups african american children good health associated mothers education level receipt informal child care receipt public health insurance uninsured status absence depression hispanic children health positively associated mothers education level receipt substance use treatment non receipt public assistance implications policy intervention discussed
present study conducted buffalo foetii obtained slaughter house curved crown rump length cvrl foetii measured age estimated days dew claws forelimb hind limb fixed neutral buffered formalin processed acetone benzene schedule paraffin sections thickness cut stained hematoxylin eosin masson trichrome periodic acid schiff alcian blue bromphenol blue stains cvrl claws comprised mesenchymal cells covered thin epidermis varying thickness advancing age cvrl wall composed layers cuboidal cells covered thin cornified cell layer cvrl foetus made stratum externum stratum medium stratum internum corium rudimentary phalanx stratum internum consisted single layer basal cells elongated nuclei rested upon basement membrane epidermis dew claws consisted single layer stratum basale layers stratum spinosum cells layers stratum granulosum cells overlying keratinized layer corium observed horny lamellae stratum internum spongy bone contained collagen reticular elastic fibers large number blood vessels cvrl stratum internum made lamellae extending inward stratum medium lamellae appeared finger like projections stage became branched cvrl onwards primary secondary branches also observed advancement foetal age histochemical study revealed moderate strong reaction acid neutral mucopolysaccharides basic proteins
evaluate associations diagnostic statistical manual mental disorders edition dsm alternative model personality disorder traits domains categorically diagnosed narcissistic personality disorder npd borderline personality disorder bpd respectively inpatient outpatient participants consecutively admitted clinical psychology psychotherapy unit san raffaele hospital inmilan italy administered personality inventory dsm pid structured clinical interview dsm axis personality disorders scid based scid participants assigned following groups npd bpd emotional lability separation insecurity depressivity impulsivity risk taking hostility significantly associated bpd diagnosis attention seeking significantly discriminated participants received scid categorical npd diagnosis separation insecurity impulsivity distractibility perceptual dysregulation dsm traits significantly discriminated bpd participants domain level analyses confirmed extended trait level findings
objective era controversy regard hydroxyurea leukaemogenicity interferon alfa ifn revived treatment philadelphia negative myeloproliferative neoplasms mpns aim single centre observational study describe frequencies second malignancies cohort mpn patients treated hydroxyurea ifn monotherapy combination agents patients methods records mpn cohort patients reviewed retrospective analysis performed patients treated patients treated ifn patients treated ifn logistic regression used compare frequencies second malignancies results patients treated significantly higher risk developing second malignancies compared patients treated ifn ifn pvalue ifn ifn value conclusion found increased risk second malignancies mpn patients treated compared patients treated ifn
appearance cues brief displays behavior related people personality performance work outcomes elections thus people present others different communication channels interaction partners form first impressions basis displayed cues current study examined whether people able read information politicians body motion rating experiment translated short video clips politicians giving speech animated stick figures animations rated trustworthiness dominance competence big five personality dimensions afterwards correlated ratings applause hecklings speakers received throughout entire speech revealed speakers whose body movements perceived high dominance high extraversion low agreeableness received applause although results obtained need support additional studies indicate body motion informative cue real life settings authors published elsevier ltd
aim present study investigates evolution illicit drug use among romanian university students methods study performed cluj napoca romania three phases study carried means anonymous questionnaires among university students aged results results show among girls lifetime illicit drugs use increased statistically significantly among boys trend also increasing prevalence illicit drug use increased dramatically percentage students reporting cannabis use almost identical total prevalence illicit drug use ecstasy second frequent drug used students consumption also increasing trend examined periods among girls among boys results bivariate correlation analyses show lifetime illicit drug use associated friends experimented illicit drugs among boys girls moreover girls declared stress management problems depressive episodes likely try illicit drugs among boys illicit drug use associated poorer academic performance conclusions data pointed study call comprehensive actions regarding prevention illicit drug use among romanian young people
paper discusses possibility using observer based approaches cardiovascular anomalies detection isolation consider lumped parameter model cardiovascular system written form nonlinear state space representation show residuals sensitive variations cardiovascular parameters abnormal opening closure valves generated since whole state easily available measurement propose associate residual generator robust extended kalman filter numerical results performed synthetic data provided
background invasive fungal infection ifi fatal infection haematology patients urgent need reliable screening methods facilitating timely diagnosis treatment real time panfungal polymerase chain reaction pcr assay based taqman technology targeting ribosomal rna gene used screen whole blood specimen obtained series haematology malignancy patients ifis materials methods panfungal pan acf assay employed investigate specimen patients duplicate suspected ifi addition twenty healthy subjects twenty patients bacterial infections taken control patients suspected ifi also diagnosed conventional methods including direct microscopy culture techniques antigen detection galactomannan antigen elisa latex agglutination cryptococcal antigen results molecular testing evaluated relation criteria proposed european organization research treatment cancer patients classified proven probable ifd results patients proven probable possible ifi one hundred four samples reverse transcription pcr positive proven cases panfungal pcr positive cases included cases revealed growth fungal blood culture two cases negative fungal blood culture cases revealed growth culture grew candida culture grew fusarium solani grew aspergillus species blood culture later five also galactomannan antigen positive five specimen negative panfungal pcr two grew trichosporon asahii one grew candida rugosa two grew cryptococcus neoformans var neoformans probable cases panfungal pcr positive also galactomannan antigen positive sensitivity specificity panfungal pcr proven cases respectively positive negative predictive values proven cases respectively conclusions panfungal pan acf real time pcr assay detect common fungal genera may used adjunct conventional methods screening ifi
new normalized least mean square nlms based identification algorithm proposed sparse systems proposed algorithm tap selection matrix utilized adaptively locate nonzero coefficients convergence process called tap selection matrix diagonal matrix consisting zeros ones ones indicating locations active coefficients iteration tap weights update based product tap selection matrix previous tap weight vector nlms style tap selection matrix updates comparing tap weight pre determined threshold value parameter choice guidelines threshold value provided facilitate practical use steady state mean square deviation also analyzed performance evaluation simulation results demonstrate proposed nlms algorithm tap selection matrix effectively locate nonzero coefficients unknown system impulse response outperforming existing nlms based algorithms sparse system identifications
persistent assumption across psychological literature talking writing one stress inherently beneficial avoiding study compared effects stress management strategies personal relational health two hundred fifty one dating individuals focused stressor current source rumination writing one stressor consecutive days without talking decreased anxiety talking continuously one stressor dating partner harmed relationship writing avoiding effect talking repeatedly one stressor relationship quality brooding however depended upon emotional support received one dating partner ability reappraise positively neutrally stressor
purpose objective present study validate existing prediction rule including age education depressive anxiety symptoms recovery expectations predictions duration sickness absence due common mental disorders cmds investigate added value work related factors methods prospective cohort study including employees reported sick cmds period september april work related factors measured baseline questionnaire experience evaluation work year follow sickness absence data retrieved occupational health register outcome variables study sickness absence yes months reporting sick cmds discrimination workers without sickness absence investigated months area receiver operating characteristic curve auc results total employees agreed participate complete data analysis discrimination poor auc auc months respectively variety work added predictor variable discrimination employees without cmd sickness absence improved auc months auc months conclusions original prediction rule poorly predicted cmd sickness absence duration adding variety work prediction rule discriminated employees without cmd sickness absence months reporting sick new prediction rule remains validated populations
objectivesthe compromised capacity bone healing osteoporotic population renders serious concern patients clinicians study aimed investigate influence csf bone reconstruction using osteoporotic animal model materials methodssixty skeletal mature female spraque dawley rats underwent bilateral ovariectomy ovx assigned three groups three months ovx defects cranial femur surgically created animals defects left unfilled filled gelatin sponge filled granulocyte colony stimulating factor csf infused specimens retrieved histomorphometric micro analyses weeks surgery resultsat early stage week week histomorphometric micro analysis demonstrated advanced bone formation femur control group week groups achieved cortical closure cranial bone advanced bone formation exhibited csf treated group early late stages although observation statistically significant conclusionsthe results indicated osteoporotic bone csf may advance bone healing cranial bone spontaneous bone formation insufficient
solve adverse effects brought resource node transfering using right local task difficult problem resource load balancing two phase pricing strategy based qos constraints proposed paper premise guaranteeing benefits resource provider cost price strategy balances load resource provider profit price theoretical analysis proves effectiveness pricing strategy algorithm pricing strategy designed paper resources node information real distributed systems used performance parameters experimental node simulation experiments performance pricing strategy tested large scale grid mission experimental results show compared traditional pricing strategies two phase pricing strategy based qos constraints vastly superior performance benefits resource provider balance resource utilization
substantial evidence behavioral social sciences accrued support numerous intervention programs policies bearing improving lives children families end clinical child family psychology review features special journal issue evolving toward nurturing society field achieved numerous advances regarding create promote nurturing environments foster successful development prevent psychological behavioral problems children youth advances cut across multiple strategies programs interventions practices public policies settings family school including preschool service sectors community domains behavioral health parenting cognitive academic functioning nutrition physical activity obesity safety many domains developmental periods childhood special journal issue showcases sampling strategies domains relevant producing optimal conditions nurturance children families
measurement morphologic characteristics evolving sediment beds around hydraulic structures crucial understanding physical processes drive scour although significant progress towards experimental characterization flow field setups complex geometries little done respect quantitative investigation dynamic sediment bed geometry mainly due limited capabilities conventional instrumentation recently developed computer vision technique applied obtain high resolution topographic measurements evolving bed base cylinder clear water scour without interrupting experiment topographic data processed derive morphologic characteristics bed excavated volume slopes bed subsequently rates scour bathymetry multiple locations statistically investigated results investigation compared existing flow measurements previous studies describe physical processes take place inside developing scour hole two distinct temporal phases initial development well three spatial regions front side wake defined expressions statistical modelling bed features derived
cyber physical systems cps heterogeneous tightly couple computation communication control along physical dynamics traditionally considered separately without comprehensive modeling formalism model based development cps involves using multitude models variety formalisms capture various aspects system design software design networking design physical models protocol design without rigorous unifying framework system integration integration analysis results various models remains hoc paper propose multi view architecture framework treats models views underlying system structure uses structural semantic mappings ensure consistency enable system level verification hierarchical compositional manner throughout paper theoretical concepts illustrated using two examples quadrotor automotive intersection collision avoidance system
paper presents computational framework developed improve serial parallel performance two dimensional unstructured discontinuous galerkin solutions hyperbolic conservation laws coding techniques employed factor advancements trending hpc technologies designed maximize loop vectorization efficiently utilize cache facilitate straightforward shared memory parallelization reduce message passing volume increase overlap computation communication today cpu technology hpc networks rapidly evolving important quantitatively assess compare methodologies standard paradigms order maximize current computational resources benchmark studies specifically investigate shallow water equations show refactored algorithm implementation able provide significant performance increase conventional elemental code structure terms cpu time parallel scalability results show serial optimizations result performance increase parallel computations improvements give rise speedup factor local problem sizes elements per core regardless overall problem size computational benchmarks performed lonestar stampede supercomputers texas advanced computing center
background history trauma linked development wide range mental health problems long lasting physiological psychological consequences importance clinicians directly questioning trauma history consistently emphasised literature aims investigate whether trauma history obtained female psychiatry inpatients inpatient admission methods study retrospective file audit female patients admitted psychiatric ward major metropolitan melbourne hospital december november results files patients mention whether patient trauma abuse history eight percent patients documentation stating trauma abuse history forty one percent patients documented evidence trauma abuse history although patients specific description provided presence current illicit drug use diagnosis borderline personality disorder variables associated increase likelihood documented trauma abuse history conclusion need clinician retraining trauma informed care model incorporation mandatory inquiry best practice guidelines generate shift culture delivery mental health care services
data structures core discipline computer engineering studies several difficulties related teaching learning contents detected academic community aim obtaining better knowledge situations present conclusions obtained evaluating results achieved students subject programming first course degree computer engineering university coruna spain students subject data structures similar contents taught informatics degree portucalense university portugal
paper designed developed new type rectifier bridge machine equipment efficiently automatic mode manual mode complete detection classification rectifier bridge laser marking pendulum work greatly improving sorting efficiency rectifier bridge mechanical structure working principle equipment expounded
emerging network functions virtualization nfv software defined networking sdn paradigms network management new network devices features immediately become available available network resources services altered optimized real time gain maximum benefit however requires real time analytics information sent sdn controllers rather traditional manual offline batch analytics deliver outputs hourly monthly systems result real time analytic becoming critical element paper describe configuration free non parametric streaming data anomaly detection analytic engine automatic system development describe design principles innovative algorithm design architecture implementation engine relation streaming data mobile finally present use cases evaluation results
low voltage high current power electronic converters receiving increasing interest industry academia application stand alone electric power generating systems multi level converter topologies well adopted solutions high voltage applications however benefits related reduction current voltage ripple well decrease switching power losses achieved also low voltage systems paper investigates application converters multi level configurations automotive systems two cases studied first case converter dual voltage automotive architecture second case low voltage three phase rectifier khz fundamental frequency electrical generator auxiliary power supply units
spreading depolarizations waves abrupt near complete breakdown neuronal transmembrane ion gradients largest possible pathophysiologic disruption viable cerebral gray matter crucial mechanism lesion development spreading depolarizations increasingly recorded multimodal neuromonitoring neuro critical care causal biomarker providing diagnostic summary measure metabolic failure excitotoxic injury focal ischemia causes spreading depolarization within minutes spreading depolarizations arise hours days due energy supply demand mismatch viable tissue spreading depolarizations exacerbate neuronal injury prolonged ionic breakdown spreading depolarization related hypoperfusion spreading ischemia local duration depolarization indicates local tissue energy status risk injury regional electrocorticographic monitoring affords even remote detection injury spreading depolarizations propagate widely ischemic metabolically stressed zones characteristic patterns including temporal clusters spreading depolarizations persistent depression spontaneous cortical activity recognized quantified describe experimental basis interpreting patterns illustrate translation human disease provide consensus recommendations electrocorticographic methods record classify score spreading depolarizations associated spreading depressions methods offer distinct advantages neuromonitoring modalities allow future refinement less invasive automated approaches
aging men associated loss bone mass impaired physical function altered body composition objective proof concept randomized double blind placebo controlled parallel group single center trial determine relative effects testosterone estradiol bone mineral density body composition physical performance older men primary outcome lumbar spine bone mineral density bmd secondary outcomes body composition muscle strength gait speed sex hormone concentrations forty three men age range years mean age years low total levels compared baseline values remained stable throughout duration trial months improved primary outcome lumbar spine bmd interventions improved knee strength months compared baseline lean body mass significantly increased group months respectively compared baseline interestingly improved fast gait speed months respectively summary proof concept study confirms aromatization required maintaining bmd older men low levels trial also uncovered novel finding aromatization required improvement fast gait speed observation needs verified future studies
propose analog front end integrated circuit design readout roic applies fixed voltage bias sensing method capacitance transimpedance amplifier ctia input stage order simplify circuit structure roic sensor characteristic control sample hold stage order display control signal detected sensor using focal plane array differential delta sampling circuit proposed effectively removes fixed pattern noise addition two stage variable gain amplifier equipped rail rail fully differential operational amplifier applied roic achieve high voltage sensitivity output characteristic proposed device linearity error rate less checking performance roic using hspice simulation chip manufactured measured using united microelectronics corporation japan standard cmos process confirm simulation results actual design close agreement measurement results
goal paper examine abstract non neuronal level concepts processes cognition introduce model episode processing includes processing perception memory ordered events attentional processes forgetting including constant non constant time based decay confusions distinctiveness items false memories suppression
although much attention paid question whether violent video games increase aggressive behaviour little attention paid games might encourage antecedents gun violence study examined product placement attractive game presentation certain real world firearm brands might encourage gun ownership necessary antecedent gun violence sought study virtual portrayal real world firearm bushmaster could influence players attitudes towards specifically gun ownership general college undergraduates played one four modified video games gun science fiction control gun power strong weak subjects design despite collecting many outcomes examining many potential covariates moderators experimental assignment little influence outcomes product evaluations purchasing intentions regard attitudes towards public policy estimation gun safety also influenced experimental condition although might better tested comparison violence control condition contrast gender political party dramatic associations outcomes conclude product placement shapes attitudes towards firearms effects need studied stronger manipulations sensitive measures
selecting relevant factors particular domain utmost interest machine learning community paper concerns feature selection process twin support vector machine twsvm powerful classification method constructs two nonparallel hyperplanes order define classification rule besides euclidean norm proposal includes second regularizer aims eliminating variables twin hyperplanes synchronized fashion baseline classifier twin svm implementation based second order cone programming confers robustness approach leads potentially better predictive performance compared standard twsvm formulation proposal studied empirically compared well known feature selection methods using microarray datasets succeeds finding low dimensional solutions highest average performance among methods studied work
one hand compared traditional relational xml models graphs expressive power widely used today hand various applications social computing trigger pressing need new search paradigm article argue big graph search one filling gap first introduce application graph search various scenarios formalize graph search problem give analysis graph search evolutionary point view followed evidences industry academia analyze difficulties challenges big graph search finally present three classes techniques towards big graph search query techniques data techniques distributed computing techniques
objectives australia universal health insurance system medicare generates large amounts data pocket expenditure dope highly aggregated statistics routinely published primary purpose develop indices medicare administrative data quantify changes level distribution oope hospital medical services time methods data obtained australian hypertension absolute risk study involved patients aged years socio economic clinical information collected linked medicare records five year period march fisher price quantity indices used evaluate year year changes dope relative concentration index used evaluate distribution dope across socio economic strata results price index indicates overall oope rising faster inflation considerable variation across different types services oope professional attendances rose five year period items fell around concentration indices adjusted demographic factors clinical need indicate dope tends higher among higher incomes conclusions major challenge utilizing large administrative data sets develop reliable easily interpretable statistics policy makers price quantity concentration indices represent statistics move beyond average author published elsevier ireland ltd
establishment urbanized environments associated changes physiology behaviour problem solving compared speed learning urban rural female common mynas acridotheres tristis using standard visual discrimination task followed reversal learning phase also examined quickly bird progressed different stages learning including sampling acquisition within initial reversal learning persistence following reversal based reliance different food resources expected urban mynas learn reversal learn quickly sample new contingencies proportionately longer learning quantified first presentation criterion achievement urban mynas took trial blocks learn initial discrimination well reversed contingency rural mynas detailed analyses level stage revealed urban mynas explored novel cue outcome contingencies longer despite transitioning faster subsequent acquisition remained overall slower rural females findings draw attention fine adjustments learning strategies response urbanization caution interpreting speed learn task reflection cognitive ability
isolated male hypogonadotropic hypogonadism ihh congenital acquired mean platelet volume mpv determinant platelet function independent risk factor cardiovascular disease cvd aim study evaluate mpv values male ihh relationships mpv low testosterone levels metabolic syndrome impaired fasting glucose ifg cardiovascular risk thirty one patients untreated normosmic isolated male ihh mean age years age bmi matched healthy individuals mean years included study hormonal analyses done chemiluminesance assay study participants evaluated biochemical platelet parameters mpv significantly higher ihh controls respectively mpv positive correlation metabolic syndrome ifg insulin homeostasis model assessment homa bmi mpv negative correlation total testosterone free testosterone luteinizing hormone fsh although control patients metabolic syndrome ifg ihh patients metabolic syndrome ifg significantly often respectively age metabolic syndrome ifg bmi fasting glucose insulin crp homa independent predictive factors mpv multiple regression analysis results suggest men ihh susceptible increased platelet activation increased mpv values contribute increased risk cardiovascular complications study observed ihh low testosterone may feature metabolic syndrome ifg increased mpv levels cardiovascular risk young adult males copyright wolters kluwer health inc rights reserved
personal intelligence involves capacity reason personality personality related information studying ability based measures personal intelligence creates virtuous cycle better measurement better theoretical understanding study conduct item level analysis test personal intelligence topi explore people problem solving abilities area personal intelligence divided consistency congruency factor concerned understanding traits associated behaviors dynamic analytic factor involved understanding personality processes goals finding cross validated study study examined correlates two factors understanding abilities involved personal intelligence may help educate people better solve problems personality elsevierltd rights reserved
research personality types recently received increasing attention field personality social psychology aim present study investigate relationship adolescents personality types prosocial aggressive behavior sample chinese adolescents recruited complete neo five factor inventory children behavior inventory results revealed four personality types chinese adolescents resilients withdrawn undercontrollers ordinary results anova showed resilient adolescents highest scores whereas withdrawn adolescents lowest scores measure prosocial behavior withdrawn undercontrolled adolescents highest scores resilient adolescents lowest scores measure aggression first study chinese adolescents personality types relationship chinese adolescents personality types prosocial behavior aggression results implications understanding western notions personality chinese population elsevier ltd rights reserved
ideal gas equation log rho entropy pressure rho mass density define interconnection entropy temperature density plasma therefore different phenomena relating plasma entropy need investigated employing braginskii transport equations nonuniform electron ion magnetoplasma two new parameters entropy distribution function entropy gradient drift defined new dispersion relation obtained dependence anomalous transport entropy also proved results like monotonicity entropy principle second law thermodynamics proved new definition entropy work open new horizons fusion processes controlling entropy tokamak plasmas particularly pedestal regions mode space plasmas also engineering sciences
paper study application version method simplest equation obtaining exact traveling wave solutions zakharov kuznetsov equation modified zakharov kuznetsov equation generalized forms duffing type equation used simplest auxiliary equation meantime proposed method proved powerful mathematical tool obtaining exact solutions nonlinear partial differential equations mathematical physics
dense networks low cost wireless sensors potential facilitate prolific data collection large complex infrastructure costs lower historically associated tethered counterparts wireless telemetry previously proposed structural monitoring comparatively less research focused creation complete scalable data management system manages storage interrogation wireless sensor data paper reports development novel wireless structural monitoring system specifically tailored large scale civil infrastructure systems architecturally combining dense wireless sensor networks suite information technologies remotely accessible internet architectural overview proposed internet enabled wireless structural monitoring system presented including description functional elements example wireless sensors database server application programming interfaces monitoring system architecture proposed validated new carquinez alfred zampa memorial bridge vallejo california permanent wireless monitoring system installed consisting wireless sensor nodes collecting data channels bridge sensor data transferred wireless cellular connection remote database server stored available interrogation software clients granted access data illustrate ability autonomously process bridge response data stochastic subspace identification method used extract accurate modal characteristics bridge used update high fidelity finite element models bridge internet enabled wireless structural monitoring system proved scalable large number nodes thus far proven stable reliable long term use
objectives increasing proportion people living hiv older adults may require specialized care adverse physical psychological effects hiv infection may greatest among older people lived longer hiv methods astra study cross sectional questionnaire study hiv diagnosed adults men sex men heterosexual men women recruited clinics associations age group physical symptom distress significant distress least one symptoms depression anxiety symptoms scores phq gad respectively health related functional problems problems least one three domains euroqol assessed adjusting time diagnosed hiv infection gender sexual orientation ethnicity results age distribution participants years overall prevalences physical symptom distress depression symptoms anxiety symptoms functional problems trend found prevalence physical symptom distress age adjusted odds ratio trend across age groups confidence interval prevalence depression anxiety symptoms decreased age adjusted adjusted respectively functional problems increased adjusted contrast longer time diagnosed hiv infection strongly independently associated higher prevalence symptom distress depression symptoms anxiety symptoms functional problems trends adjusted analysis conclusions among people living hiv although health related functional problems common older age physical symptom distress mental health favourable results suggest longer time diagnosed hiv infection rather age dominating factor contributing psychological morbidity lower quality life
betweenness measure centrality node network normally calculated fraction shortest paths random walk paths flow units node pairs pass node interest betweenness sense measure influence node possesses spread information network however traditional betweenness based information dissemination one node another conceptually suitable epidemics information disseminated one node multiple neighboring nodes destinations address problem propose novel betweenness measure based epidemics epidemic betweenness counts average number following nodes influenced node interest becomes epidemic source intermediary measure reflects potential influence node epidemic complex networks justify measure introduce real complex networks estimate average influential scale node epidemics large number simulations compare simulation results epidemic betweenness another seven classic measures eigenvector katz provide correlation studies expose differences epidemic betweenness capturing influential nodes find epidemic betweenness exclusively measure accurately present potential influence node epidemics finally example application epidemic betweenness measure explains finding recent research unpopular users nodes small degree could also lead large cascades epidemics
despite substantial body research examining relationship child maltreatment externalizing antisocial criminal behavior problems theory rarely applied current empirical research literature lack theoretical application limits opportunities understand mechanisms explaining maltreatment associated behavior problems best strategies intervening interrupt association purpose paper analyze relevant theoretical perspectives develop conceptual model explaining relationship maltreatment behavior problems intervening role child welfare services six theoretical perspectives selected analysis ecological model transactional model attachment theory life course perspective social learning perspective social biological models applying theories understanding maltreatment behavior problem association role child welfare services intervening insights theories synthesized conceptual model policy practice implications model discussed focus implications child welfare workers administrators policymakers elsevier ltd rights reserved
flutter stability long span suspension bridges erection problematic susceptible influenced many factors final state described paper numerical flutter stability analyses performed construction process zhongdu bridge yangtze river using commercial package ansys effect initial wind attack angle sequence deck erection stiffness reduction stiffening girders structural damping cross cables discussed detail found non symmetrical sequence deck erection continued aerodynamically favourable deck erection long span suspension bridges best erection sequence investigated design phase initial wind attack angle advantageous aerodynamic stability disadvantageous compared initial wind attack angle deck erection stiffness reduction stiffening girders slight effect flutter wind speed suspension bridge erection structural damping great impact especially early erection stages
iron essential element numerous fundamental biologic processes excess iron toxic abnormalities systemic iron balance common patients chronic kidney disease iron administration mainstay anemia management many patients review provides overview essential role iron biology regulation systemic cellular iron homeostasis imbalances iron homeostasis contribute disease implications chronic kidney disease patients
improving health care transition process youth autism spectrum disorder asd critically important study designed examine overall national transition core outcome among youth asd component measures health care transition planning fewer youth asd meet national transition core outcome among youth asd greater disparity health care transition planning non hispanic black youth youth family income federal poverty line youth severe activity limitation continued advocacy research training efforts needed reduce disparities receipt health care transition planning services youth asd
proposed aloe cream could reduce severity skin toxicity radiation therapy breast cancer present arm study compared control powder double blind aloe placebo cream found patients used dry powder skin care radiation therapy lower severity skin toxicity patients used either placebo aloe cream recommend dry powder regimen radiation therapy reduce severity skin toxicity background efficacy aloe extract reducing radiation induced skin injury controversial purpose present arm randomized trial test efficacy quality tested aloe extract reducing severity radiation induced skin injury secondarily examine effect moist cream versus dry powder skin care regimen materials methods total patients breast cancer randomized powder aloe cream placebo cream acute skin toxicity scored weekly treatment weeks using modified point catterall scale patients scored symptom severity using point likert scale kept acute phase diary results aloe formulation reduce acute skin toxicity symptom severity patients greater body mass index likely develop acute skin toxicity similar pattern increased skin reaction toxicity occurred study creams compared dry powder regimen conclusion evidence found support prophylactic application quality aloe extract cream improve symptoms reduce skin reaction severity results support dry skin care regimen powder radiation therapy
aimswe aimed compare efficacy safety mirabegron adrenoceptor agonist imidafenacin anticholinergic agent overactive bladder patients methodswe conducted multicenter prospective randomized cross study hospitals japan december june enrolled female patients overactive bladder aged years never received treatment condition patients assigned group group patients administered mirabegron per day weeks followed week washout period imidafenacin per day weeks order drug administration reversed group resultsa total patients group patients group continued receive treatment weeks respectively mirabegron administration significantly improved overactive bladder symptom score oabss urinary frequency per voided volume per micturition number nocturia episodes per night week moreover imidafenacin administration improved variables except number nocturia episodes per night week significant difference observed drug effects mirabegron imidafenacin although imidafenacin administration significantly increased scores dry mouth blurred vision constipation mirabegron administration conclusionsmirabegron imidafenacin efficacy imidafenacin administration associated higher rate dry mouth blurred vision constipation compared mirabegron administration neurourol urodynam wiley periodicals inc
industrial emissions must dramatically reduced avoid potentially dangerous effects climate change order contribute necessary cuts article focuses energy material efficiency sheet metal forming processes considered include traditional methods drawing stretch forming newer technologies developed recent decades hydroforming fluid cell forming superplastic forming incremental sheet forming analysis conduct case studies forming processes leading car aerospace manufacturers case studies include electrical power measurements forming machines also consider impacts making dies sheet metal lubricant cradle gate energy demands environmental impacts modeled simapro using data based ecoinvent database values results show idling consumes significant electricity however incremental forming impacts press electricity small compared impacts making sheet metal case studies inform generalized models process allow per part impacts estimated based final part material size surface area thickness depth number parts produced die set lifespan models used investigate potential reduce cradle gate energy requirements using incremental forming instead drawing form parts found significant potential savings small production runs consistent part development prototyping however savings vary depending part size relative buy fly ratio material yield two processes results study highlight small production numbers die lifespan impacts die making important however production numbers increase one hundred parts per die set impacts making sheet metal become dominant therefore concluded researchers interested reducing environmental impacts sheet metal forming concentrate innovations would reduce sheet metal blanking post forming trimming losses elsevier rights reserved
effective interpersonal coordination fundamental robust social interaction ability anticipate coactor behavior essential achieving coordination however coordination research focused behavioral synchrony occurs simple periodic movements coactors thus little known anticipation occurs complex everyday interaction research dynamics coupled neurons human motor control electrical circuits laser semiconductors universally demonstrates small temporal feedback delays necessary anticipation chaotic events therefore investigated whether similar feedback delays would promote anticipatory behavior social interaction results revealed coactors able anticipate others chaotic movements experiencing small perceptual motor delays also exhibited movement patterns equivalent complexity suggests delays including within human nervous system may enhance rather hinder anticipatory processes underlie successful social interaction
increased oxidative stress brain lead increased sympathetic tone may induce kidney dysfunction previously shown maternal cigarette smoke exposure leads significantly increased oxidative stress inflammation brain kidney well reduced brain kidney mitochondrial activity closely associated significant kidney underdevelopment abnormal function adulthood male offspring study aimed investigate impact maternal brain kidney health female offspring study mouse dams exposed two cigarettes twice daily weeks prior gestation pregnancy lactation brains kidneys female offspring collected days weeks subject analysis found mrna expression brain inflammatory markers interleukin receptor toll like receptor significantly increased offspring brain mitochondrial activity markers however increased increased antioxidant activity kidney development function female offspring different control offspring concluded although brain inflammatory markers upregulated female offspring protected indicators brain oxidative stress endogenous antioxidant mitochondrial dysfunction well abnormal kidney development function adulthood
city landmark building railway passenger stations often large space crowded extremely comfortable resulted high energy consumption taking taiyuan south railway station case paper introduced green energy saving design adaptable climate natural ventilation palisade structure shading natural lighting ventilation heating meanwhile design effects verified simulation experimental test
previous alliancing research seldom addressed implication transaction costs impact transaction attributes transaction costs project alliancing using multiple regression analysis sample australian alliances study tests differential impact uncertainty frequency various dimensions contracting parties asset specificity three individual transaction cost elements set monitoring enforcement costs results indicate impact transaction attributes transaction costs varies uncertainty positive impact three transaction cost elements frequency dimensions contracting parties asset specificity positively associated set costs monitoring costs however apply enforcement costs findings provide empirical evidence support transaction cost economics prediction regarding influence transaction attributes transaction costs australian construction industry thereby add another perspective knowledge base construction management discipline measurement methods transaction attributes transaction costs presented valuable implications future research
study examined associations teacher attunement aggressive students students characteristics sample youth grade classrooms assumption certain student characteristics may either prime hinder teachers attunement aggressive students teacher attunement measured agreement teacher peer nominations students start fights teachers rated students following characteristics academic competence affiliation popularity internalizing behavior olympian qualities higher affiliation popularity internalizing behavior associated decreased odds teacher attunement aggressive youth higher olympian qualities associated increased odds teacher attunement aggressive youth implications interventions discussed aggr behav wiley periodicals inc
paper new vlsi implementable hopf oscillator dynamic plasticity proposed next generation portable signal processing application circuit realizable piece wise linear function used govern frequency adaptation characteristic proposed oscillator furthermore straightforward method suggested extract frequency component input signal mathematical model oscillator derived shown using vhdl ams model despite using new nonlinear function oscillator exhibits characteristics learning behavior original one improved learning time subsequently equivalent circuit model transistor level implementation oscillator suggested mathematical model confirmed system circuit level simulations capability oscillator extract frequency futures without explicit signal processing shown examples synthetic real life emg signals
highly optimised reconfigurable hardware architecture proposed bit block ciphers misty kasumi wide area cryptographic applications reconfigurable hardware architecture comprised reconfigurable components consisting function function xor function designed perform misty kasumi algorithms round transformation functions addition reconfigurable function adequate generate misty extended keys onward use misty round transformation function substitution functions misty kasumi algorithms optimised area throughput common sub expression elimination xor logic combined permutation combination technique gates reduces area considerably whereas parallel execution improves throughput design approach application specific integrated circuit asic implementations using synopsys design complier smic achieved area nand gates throughput mbits misty kasumi respectively synthesised fpga implementation using xilinx artix fpga yielded area configurable logic block clb slices throughput mbits misty kasumi respectively detailed design performance analysis reconfigurable hardware architecture bit block ciphers misty kasumi asic implementations described
evaluation benchmarking nosql databases challenging due variety query languages also due denormalized scheme allows include non scalar values repeatable structures nested documents rather young age nosql databases many studies conventional solution enable fair comparison performance relational databases paper present modeling evaluation extensible open source solution called nowog purpose generate large synthetic database workloads also mimic real world database applications allowing application specific benchmarking introduce generic language description workload characteristics independent particular database query language underlying storage model therefore applicable various database management systems thereby nowog language covers different distributions read write operations various data types numbers texts arrays nested documents evaluation demonstrate nowog ability mimic real workload application using environmental satellite data stored mongodb also scalability produce big workloads
objective review current literature evidence regarding feasibility efficacy smartphone based cognitive behavioral intervention mobile applications compare number applications commercial marketplaces explore potential steps forward research field methods literature search conducted papers published february featuring quantitative results clinical outcomes regarding use smartphone cognitive behavioral therapy dialectical behavioral therapy behavioral activation acceptance commitment therapy search number related applications available consumers apple google play commercial marketplaces also conducted results nine studies described articles identified featured use smartphones cognitive behavioral interventions majority studies presented pilot results suggesting potential feasibility efficacy apps four hundred forty seven related applications found available commercial marketplaces conclusions research base smartphone based cognitive behavioral intervention mobile applications preliminary point although results encouraging discrepancy published literature commercial applications available consumers suggest potential steps forward research advance clinical use research topic
mucormycosis emerged important cause invasive fungal infection patients hematologic malignancies gastrointestinal mucormycosis unusual presentation invasive fungal infection causes considerable morbidity mortality outcomes due part nonspecific presentation results delays diagnosis treatment successful treatment gastrointestinal mucormycosis involves surgical debridement appropriate antifungal therapy
helminthiasis may ameliorate inflammatory diseases inflammatory bowel disease asthma information immunomodulators ascaris lumbricoides scarce could important considering evolutionary relationships helminths humans evaluated immunomodulatory effects recombinant cystatin lumbricoides acute model dextran sodium sulphate dss induced colitis mice lumbricoides cdna library obtained recombinant cystatin ral cpi protease activity inhibition demonstrated cathepsin papain immunomodulatory effects evaluated two intraperitoneal doses mice dss induced colitis body weight colon length disease activity index dai histological inflammation score myeloperoxidase mpo activity gene expression cytokines cytokines levels colon tissue analysed treatment ral cpi significantly reduced dai mpo activity inflammation score without toxic effects also tgf gene overexpression observed ral cpi treated group compared dss exposed control healthy mice furthermore reduction tnf expression found confirmed levels cytokines colonic tissue conclusion ral cpi reduces inflammation mouse model dss induced colitis probably increasing expression anti inflammatory cytokines reducing pro inflammatory ones
heterozygous rare homozygous mutations proline rich transmembrane protein prrt underlie group paroxysmal disorders including epilepsy kinesigenic dyskinesia episodic ataxia migraine mutations lead impaired prrt expression function recently important role prtt neurotransmitter release machinery brain development synapse formation uncovered work characterized phenotype mouse prrt gene constitutively inactivated prrt beta galactosidase staining allowed map regional expression prrt intense cerebellum hindbrain spinal cord localized restricted areas fore brain prrt mice normal birth display paroxysmal movements onset locomotion persist adulthood addition adult prrt mice present abnormal motor behaviors characterized wild running jumping response audiogenic stimuli ineffective wild type mice increased sensitivity convulsive effects pentylentetrazol patch clamp electrophysiology hippocampal cerebellar slices revealed specific effects cerebellum prrt highly expressed consisting higher excitatory strength parallel fiber purkinje cell synapses high frequency stimulation results show prrt mouse reproduces motor paroxysms present human prrt linked pathology proposed experimental model study pathogenesis disease well testing personalized therapeutic approaches authors published elsevier inc
address task discrete time modeling nonlinear dynamic systems multiple outputs using measured data area control engineering task typically converted set classical regression problems one output solved nonlinear regression approach fuzzy models takagi sugeno form popular context use lolimot tree learning method build fuzzy linearmodel trees paper propose implement empirically evaluate three extensions fuzzy linear model trees first consider evaluate multioutput models second propose use ensembles models third investigate use search heuristic based simulation error opposed one step ahead prediction error specific context modeling dynamic systems finally perform empirical evaluation compare approaches six multioutput case studies using measured simulated data noise case studies include modeling inverse dynamics robot arm well five additional process industry systems ensembles improve performance single multioutput trees heuristic specific modeling dynamic systems improves performance slightly multioutput model trees exhibit comparable worse predictive performance set single output models providing compact model overall recommend use bagging single output lolimot models learned using simulation error search heuristic
static var compensators svc improve power quality indices voltage flicker unbalances power factors power systems properly controlled different nonlinear time varying loads generate parameters one great nonlinear loads electric arc furnace eaf causes waveform distortions voltage unbalances fluctuations paper new digital prediction based control thyristor switched capacitors tscs proposed compensate actual steel industrial plant digital control based generating adequate synchronous pulses calculating required suitable susceptance measuring correct reactive power proposed tsc improved means feedback voltage power factor predictive method based time series recursive least square dynamic learning factor applied estimate eaf reactive power future tsc performance enhanced reducing natural time delay band pass harmonic filter designed compensate load current harmonics protect capacitor banks tsc finally suggested tsc implemented steel industrial plant actual power system eafs modeling experimental results indicate effectiveness proposed tsc
background menopause onset aging women process women experience physical changes may impact upon psychological social status also affecting quality life furthermore several psychological changes following menopause shown act pro oxidant association psychological status modify quality life oxidative stress postmenopausal women still unclear aim study determinate relationship oxidative stress psychological disturbances low self esteem depressive mood anxiety quality life postmenopausal women methods carried cross sectional study premenopausal postmenopausal women mexico city markers oxidative stress measured plasma lipoperoxide levels erythrocyte superoxide dismutase glutathione peroxidase activities total antioxidant status calculate stress score global oxidative stress status cut values parameter score range representing severity markers modifications women rated using coopersmith self esteem inventory zung self rating anxiety zung self rating depression scales quality life brief results postmenopausal women low quality life quality life brief subscales higher stress score compared premenopausal women high quality life found positive correlation among lipoperoxide levels zung self rating anxiety zung self rating depression score respectively negative correlation quality life brief scores postmenopausal women multiple linear regression analysis revealed average lipoperoxide levels increase mol every point increase coopersmith self esteem inventory mol every point decrease quality life brief adjusted pro oxidant factors zung self rating anxiety zung self rating depression scales scores also contribute increase lipoperoxides levels significant conclusion findings suggest oxidative stress increased postmenopausal women psychological disturbances low quality life
background ketogenic diet high fat low carbohydrates mimics metabolic state starvation used therapeutically pharmacoresistant epilepsy known generation triiodothyronine thyroxine decreases fasting periods aim study evaluate thyroid function children receiving least year due drug resistant epilepsy methods total patients males mean age years median interquartile range iqr years treated least year enrolled seizure control side effects compliance diet recorded free free thyroid stimulating hormone tsh levels measured baseline post treatment months mann whitney test repeated measures analysis variance anova post hoc bonferroni correction logistic regression analysis used data analysis results hypothyroidism diagnosed thyroxine medication initiated eight seven five patients patients total months therapy respectively logistic regression analysis showed baseline tsh elevation odds ratio confidence interval female gender independent risk factors development hypothyroidism treatment epileptic children conclusions causes thyroid malfunction thyroxine treatment may required first report documenting effect treatment thyroid function thyroid function monitored regularly epileptic patients treated
silver nanoparticles agnps increasingly used antimicrobial agent various consumer products silver release products occurs use washing disposal varying rates wastewater system eventually aquatic ecosystems constructed wetlands wetlands designed water pollution control represent unique type water treatment system beginning receive growing amounts influent agnp loadings order examine potential impacts health ongoing utility constructed wetlands evaluated susceptibility developed resistence constructed wetland microbial communities two types agnps citrate polyvinylpyrrolidone pvp coated ionic microcosms representing unplanted batch fed subsurface flow constructed wetland exposed agnp contaminated simulated wastewater days experiments triplicated included unexposed controls analysis total interstitial water biofilm matrix via inductively coupled plasma mass spectrometry icp revealed majority agnps partitioned interstitial water accumulated biofilm presumably sediment matrix significant alteration microbial community function assessed via community level physiological profiling clpp structure using denaturing gradient gel electrophoresis dgge observed following initial day exposure subsequent situ dose response testing wide concentration range provided evidence increased resistance toxicity previously exposed microbial communities compared controls situ evaluated susceptibility microbial communities agnps varied treatments significant reductions catabolic activity observed ionic citrate coated agnps pvp coated agnps findings suggest wetland microbial communities tolerate develop resistance lower levels situ agnp exposure relatively short time however situ toxicity observed past certain threshold concentrations threshold varies depending original form agnp elsevier rights reserved
pressure determined globally incompressible euler equations localized change initial velocity immediate effect throughout space solutions physically meaningful one would expect effects decrease distance localized change giving solutions type stability indeed case solutions spatial decay easily shown consider difficult case solutions lacking spatial decay show stability still holds albeit somewhat weaker form
subcontracting common practice modern construction industry performance construction projects adversely affected relationships main contractors subcontractors properly managed therefore relationships main contractors subcontractors becoming important success construction projects based comprehensive questionnaire survey hong kong construction industry relationship main contractors subcontractors studied main contractors local industry classified four clusters according nature relationship subcontractors namely adversarial coopetitive collaborative partnering furthermore impact relationships main contractor competitiveness critical factors affecting collaborative partnering relationships main contractor competitiveness also explored findings research reveal good relationships subcontractors positively advantageously associated main contractor competitiveness long term partnering relationship based win win principles likely benefit parties construction practice american society civil engineers
probabilistic relational databases play important role uncertain data management informally probabilistic database probability distribution set deterministic databases namely possible worlds existing initialization methods transform possible worlds representation chosen representation make formulae tuples long efficient initialization method proposed providing equation generate simplified formulae tuples experimental study shows proposed method greatly simplifies formulae tuples without additional time cost subsequent queries benefit simplified formulae tuples
community detection common problem various types complex networks emerging large scale real networks like social networks community detection meets new technology challenges extremely large computational cost lack prior information although several literatures recently try solve new challenges still limitations parallelism running time scale data increases sharply parallelism necessary codes exist work analyze process random walking graphs observe weight edge gotten processing vertices visited walker could indicator measure closeness vertex connection based finding first propose novel parallel computing community detection algorithm big unweighted undirected graphs true sense algorithm consists three steps including random walking using multiple independent random walks weight calculating edges community detecting time complexity algorithm log without prior information order implement parallel computing algorithm efficiently also propose novelty graph partition model experimental results show algorithm capable detecting community structure overlapping parts communities real world effectively reduce running time times least handling challenges community detection big graph era elsevier ltd rights reserved
novel series arylsulfonamide derivatives aryloxy propyl piperidines designed obtain potent htr antagonists among compounds evaluated herein chloro biphenyl yloxy hydroxypropylipiperidin benzenesulfonamide exhibited antagonistic properties showed selectivity selected serotoninergic dopaminergic receptors well serotonin noradrenaline dopamine transporters compound demonstrated significant antidepressant like activity forced swim test tail suspension test augmented antidepressant effect inactive doses escitalopram selective serotonin reuptake inhibitor bupropion dopamine reuptake inhibitor fst mice similarly exerted pro cognitive properties novel object recognition task cognitively unimpaired conditions rats extended pharmacological profile especially augmentation effect identified antagonist ssri activity seems promising regarding complexity affective disorders potentially improved outcomes including mnemonic performance elsevier ltd rights reserved
comment field critique present author paper einstein relativistic time dilation critical analysis suggested experiment given comment reasserts muon experiments give convincing direct evidence relativistic time dilation high precision claimed comment emphasizes convincing tests predictions special relativity must presume validity special relativity
objective current study introduces parental emotional response children index perci new questionnaire specifically designed measure parents emotional response adhd related behaviors delay discounting delay aversion method perci completed parents year old children without adhd results factor analysis confirmed five separate subscales acceptable psychometric properties parents children adhd reported stronger emotional response adhd behaviors parents typically developing children inattention symptoms evoked strongest emotional response parents regardless child diagnostic status conclusion parents emotional responses appear differentiated terms specific adhd related triggers mapping onto different domains adhd delay related responses research required understand changes parental emotional responses time impact children developmental trajectories
purpose purpose paper present maturity model developed assess knowledge sharing jordanian construction sector design methodology approach research conducted three stages first stage consisted review literature documenting variables literature highlight influence organizations second stage designed maturity model development identifying cultural factors affect jordanian construction sector questionnaires interviews factor analysis used find possible relationships cultural variables followed semi structured interviews third stage initial maturity model refined another set semi structured interviews findings model presented paper includes three levels maturity first level identifies whether variable barely exists company practices second level shows occasional techniques company uses increase activities final level demonstrates importance variable affecting fundamentally ingrained company vision mission strategy operations originality value research developed model used measure organization although model applied construction industry easily modified fit sectors
paper identifies several directions improve performances operating mechanism medium voltage circuit breakers order get variable moving characteristics moving contact adjusted value switching current different drive solutions currently used operation vacuum circuit breakers analyzed comparatively well performances meet depending application solution proposes use system microprocessor able independently control operation moving contacts stepper motors acquisition circuit breaker functional parameters
background aged long term residents suffer wide range skin problems dry skin associated severe pruritus scratching inflammation prevalent exact figures lacking maintaining skin tissue health well enhancing quality life major goals institutional long term care using mild moisturizing skin care products considered improve skin barrier reduce adverse events however available evidence supporting particular skin care approaches limited objective study aims answering two general questions prevalence skin conditions skin diseases aged nursing home residents associated general person health related characteristics structured skin care regimen improve skin health aged nursing home residents design methods using random sample nursing homes state berlin residents seven institutions undergo nursing medical dermatological assessments biophysical skin parameters like transepidermal water loss skin surface measured residents dry skin included three arm randomized pragmatic trial investigating effectiveness two standardized skin care regimens compared usual care primary outcome overall dry skin score follow period two months settings institutional long term care facilities berlin germany participants long term care residents years gave informed consent sample size statistical methods due explorative nature study formal sample size analysis possible expected sample size first part study considered sufficiently large obtain precise point estimates planned allocate eligible nursing home residents ratio per group intervention part detectable mean difference using group sizes would groups depending level measurement variables described using absolute relative frequencies means medians associated spread estimates possible multivariable associations analyzed primary outcome dry skin described mean differences one way anova analysis post hoc pairwise two sample tests results study started september results expected july trial registration study registered https clinicaltrials gov show nct elsevier ltd rights reserved
work multidisciplinary experience aimed study permanent deformations hull regatta sailing yacht described particular procedure compare two different surfaces hull small sailing yacht designed manufactured university palermo developed first one represents original cad model second one obtained means reverse engineering approach reverse engineering process performed automatic close range photogrammetry survey allowed obtain accurate measures hull modelling step well known computer graphics software rhinoceros reverse engineering model checked two different procedures implemented graphical algorithm editor grasshopper first procedure allowed compare photogrammetric measurements rebuilt surface order verify reverse engineering process led reliable results second implement measure deviations original cad model rebuilt surface hull procedure given possibility highlight permanent deformation hull due errors production phase excessive loads use obtained results demonstrated developed procedure efficient able give detailed information deviation values two compared surfaces
different studies field agricultural engineering successfully related irrigation needs plants percentage green cover crop images using simple allometric equations therefore problem segmenting plants soil digital images becomes key component many water management systems development automatic computer vision algorithms avoids slow expensive procedures require supervision human experts sense color analysis techniques shown yield best results accuracy efficiency paper describes design development new web application two different color segmentation techniques estimate percentage green cover system allows remote monitoring crops including functionality upload images analyze images database storage graphical visualization results extensive experimental validation tool carried lettuce crop variety little gem two segmentation methods based probabilistic color models using histograms clustering rgb space using fuzzy means algorithm compared respect manual segmentation technique allows human expert validate outcome process image experimental results demonstrate feasibility two automatic methods substitutes supervised process first method achieves relative error obtained segmentation second method error techniques require less processing time server equations compute crop coefficient parameter also included validated kind crop elsevier rights reserved
paper studies imposing norms contribution behavior affects individuals intrinsic motivation consider church levy catholic church germany collects charitable donation despite fact levy legally tax design randomized field experiment treatments informing individuals levy tax demonstrate treatment effects differ across motivational types among weakly intrinsically motivated individuals communicating legal norm results significant crowd intrinsic motivation contrast strongly intrinsically motivated individuals show treatment response elsevier rights reserved
objective collect data vitamin serum levels large number rheumatoid arthritis patients different european countries investigate relation disease activity disability quality life possibly construct new patient reported outcome pro questionnaire order self estimate risk vitamin insufficiency deficiency related clinical implications pro methods european league rheumatism eular supported cross sectional study project cli involved patients mean age years mean disease duration years age sex matched healthy subjects rheumatologists working academic institutions hospital centres well pare organizations patient representatives european countries serum samples level measurement collected winter time analyzed central laboratory using chemiluminescence immunoassay diasorin patient past medical history recorded patients provided three questionnaires rheumatoid arthritis impact diseases score raid health assessment questionnaire haq new pro questionnaire time serum sampling pro questionnaire consisted three domains symptom risk score srs habitus risk score hrs global risk score srs hrs grs constructed items possibly related vitamin deficiency pro correlated clinical pro scores das crp also evaluated statistical analysis performed non parametric tests results mean serum concentration patients found significantly lower compared levels obtained matched controls statistically significant differences among several european countries negative correlations found serum levels das crp raid haq scores patients group negative correlations also found cohort enrolled patients serum concentrations srs hrs grs domains pro questionnaire conclusions first multicentre european survey add new evidences vitamin insufficiency deficiency frequent patients statistically significant differences among several countries vitamin serum concentrations seem correlate negatively significantly pro global risk score clinimetric indexes quality life disease activity disability present cohort european patients elsevier rights reserved
two experiments conducted compare effects different styles verbal criticism factual counterfactual perceptions target source quality attack counterfactual attacks resulted negative overall judgment target ratings target morality either factual attacks attack counterfactual attacks also rated positively factual attacks source counterfactual attack rated less biased target regression analyses confirmed observed effect overall judgment mediated perceived bias source greater effectiveness counterfactual attacks moderated awareness prior hostility source attack toward target
dengue virus serotype denv one four serotypes dengue viruses geographically diverse five distinct genotypes denv emerging strains lineages denv increasingly reported availability genomic data denv strains provides opportunity study population structure complete genome sequences available strains four genotypes iii isolated worldwide analyzed using population genetics evolutionary approaches map landscape genomic diversity denv population observed stratified five major subpopulations genotype formed independent subpopulations genotype iii subdivided three subpopulations giii giii giii therefore heterogeneous genotypes giii subpopulations comprise asian strains whereas giii comprises american strains giii subpopulation includes mainly american strains along strains sri lanka genetic admixture predominantly observed sri lankan strains genotype iii strains genotype inter genotype recombination observed occur non structural region several asian strains whereas extent recombination limited american strains significant positive selection found operational genes observed main driving force genetic diversity positive selection strongly operational branches leading asian genotypes helped delineate genetic differences asian american lineages thus inter genotype recombination migration adaptive evolution major determinants evolution denv elsevier rights reserved
endless metal belts play important role advanced processing lines belt machines many production processes contrast standard conveyor lines metal belts must run cylindrical return drums due high elastic modulus belt material usually high level pre stress since cylindrical return drums provide passive lateral guidance self centering actively adjusted swiveling drum axes work suitable control scheme presented guarantee set lateral position return drums even presence lateral disturbance force since lateral dynamics endless belt show strong coupling inputs outputs multivariate control approach inherent decoupling capabilities needed moreover number technological constraints must fulfilled operating conditions limited swivel angles maximum allowable tensile stress belt research work constrained model predictive control mpc therefore designed overcome aforementioned problems model based description spatial domain belt travel renders model independent operating speed using model multi input multi output mimo mpg scheme derived also state space representation moreover control explicitly considers constraints control inputs maximum allowable belt stress
many large scale scientific simulations involve time evolution systems modelled partial differential equations pdes sparse grid combination technique sgct cost effective method solve time evolving pdes especially higher dimensional problems consists evolving pde set grids differing resolution dimension combining results approximate solution pde grid high resolution dimensions also extended support algorithmic based fault tolerance also important computations scale paper present two new parallel algorithms sgct supports full distributed memory parallelization dimensions component grids well across grids well direct algorithm called directly implements sgct combination formula give details design implementation partial sparse grid data structure needed efficient implementation second algorithm converts component grid hierarchical surpluses uses direct algorithm hierarchical surpluses conversion hierarchical surpluses also important algorithm right requires technique called sub griding order correctly deal combination small surpluses analysis indicates direct algorithm minimizes number messages whereas hierarchical surplus minimizes memory consumption offers reduction bandwidth factor dimensionality sgct however offset incomplete parallelism factor load imbalance practical scenarios analysis also indicates suitable bandwidth limited regime direct algorithm scalable respect experimental results including strong weak scalability algorithms indicates scenarios practical interest sufficiently scalable support large scale sgct direct algorithm generally better performance least factor cases hierarchical surplus formation much less communication intensive shows less scalability increasing core counts altering layout processes process grids mapping processes affects performance sgct less affects even less application part sgct advection application elsevier rights reserved
objectives investigate safety tolerability efficacy long term weeks open label treatment mirabegron optional dose increase patients overactive bladder oab methods patients received mirabegron daily weeks efficacy insufficient week dose could increased safety evaluated based vital signs adverse events aes laboratory findings electrocardiogram post void residual volume treatment efficacy assessed day micturition diary king health questionnaire khq results two hundred four patients enrolled mirabegron dose maintained patients increased patients mirabegron well tolerated doses incidences aes treatment related aes patients patients respectively time course changes systolic diastolic blood pressure pulse rate considered clinically significant end treatment eot patients showed improvement frequency urgency improvements baseline eot quality life scores observed khq domains conclusions safety tolerability concerns associated mirabegron optional dose increase weeks improvement micturition variables maintained mirabegron weeks
carbon nanotube buckypapers nafion composites demonstrate potential offer combination sensing actuating abilities lightweight flexible applications materials promising future applications robotic biomedical systems paper describes modelling electromechanical conversion phenomena pertaining buckypaper nafion actuators physical properties buckypaper nafion including young modulus electrical double layer capacitance serve key factors actuators performance moreover established convolution procedure proposed approach able study hysteresis electric field generated displacement cantilevered buckypaper nafion actuators calculated show excellent agreement computed tip strains measured data wide frequency range published elsevier
paper challenging problem determining unknown parameters identifiable lti state space representation stable system addressed resorting specific infinity norm based optimization algorithm specifically assuming availability reliable fully parameterized representation system identify algorithm developed herein consists restructuring initial black box representation system dynamics via optimization dedicated maximum eigenvalue based criterion study shows infinity norm based approach seen good solution identification gray box lti state space representations extension interesting alternative reliable initialization step standard output error techniques elsevier rights reserved
hybrid electric vehicles present promising approach reduce fuel consumption carbon dioxide emissions core technology hybrid electric vehicles energy management strategy distribute torque engine electric motor study presents optimized energy management strategy based real time control operation platform control system based dspace simulator commercial hardware closed loop system first energy management strategy built using empirical analysis method reduce fuel consumption maintain balance battery state charge dynamic programming introduced achieve best fuel economy optimal gear shifting engine torque control rules extracted rule based control algorithm meanwhile genetic algorithm introduced optimize mode transition rules engine torque parallel mode iterative method defining cost function specific driving cycles second driving cycle recognition algorithm built obtain optimization result different driving cycles real vehicle model verified using hardware loop simulator virtual forward facing simulation environment energy management strategy uses code generation technology ttc controller achieve vehicle real time communication simulation results demonstrate real time energy management strategy coordinate overall hybrid electric powertrain system optimize fuel economy different driving cycles maintain battery state charge
robust multi objective optimization method truss optimum design presented robust design materials loads assumed affected epistemic uncertainties imprecise lack knowledge uncertainty quantification using evidence theory optimum design subject epistemic uncertainty undertaken addition functional objective evidence based plausibility measure failure constraint satisfaction minimized formulate robust design multi objective optimization problem order alleviate computational difficulties evidence theory based uncertainty quantification analysis combined strategy differential evolution based interval optimization method parallel computing technique proposed population based multi objective differential evolution optimization algorithm designed searching robust pareto front two truss structures shape sizing optimum design problems presented demonstrate effectiveness applicability proposed method
uncertain whether subjects mild knee osteoarthritis may risk osteoporosis exercise safely aim improving hip bone strength rct showed participating high impact exercise program improved femoral neck strength without detrimental effects knee cartilage composition previous studies examined whether high impact exercise improve bone strength articular cartilage quality subjects mild knee osteoarthritis month rct assessed effects progressive high impact exercise femoral neck structural strength biochemical composition knee cartilage postmenopausal women eighty postmenopausal women mild knee radiographic osteoarthritis randomly assigned exercise control group femoral neck structural strength assessed dual energy ray absorptiometry knee cartilage region exposed exercise loading measured quantitative mri techniques mapping delayed gadolinium enhanced mri cartilage dgemric also accelerometer based body movement monitor used evaluate total physical activity loading changes femoral neck strength participants training effects outcome variables estimated bootstrap analysis covariance significant group difference femoral neck bending strength favor trainees observed month intervention change femoral neck bending strength remained significant adjusting baseline value age height body mass participants change bending strength associated total physical activity loading exercise participation effect knee cartilage composition high impact training increased femoral neck strength without harmful effect knee cartilage women mild knee osteoarthritis findings imply progressive high impact exercise feasible method seeking prevent hip fractures postmenopausal women whose articular cartilage may also frail
target study instantaneous electromagnetic force acquisition stator side reduce vibration paper electromagnetic force acquired displacement measured strain gauge using switched reluctance motor salient poles displacements stator rotor measured additionally frequency characteristics sensor waveforms driving condition measured discussed measured results compared simulation results thus effectiveness proposed method examined proposed method effective acquire instantaneous torque radial electromagnetic force study enable vibration torque ripple reduction
main goal paper propose probability model computing probabilities dismissal securities class action cases filed united states federal district courts dismissal mean dismissal prejudice response motion dismiss filed defendants eventual dismissal discovery process proposed probability model hybrid two widely used methods logistic regression naive bayes using dataset securities class action cases filed show proposed hybrid model potential computing better probabilities either models better mean lower root mean square errors probabilities dismissal proposed hybrid model uses following features allegations generally accepted accounting principles violations allegations lack internal control bankruptcy filing class period allegations section violations securities act short term drop stock price model useful insurance companies underwrite directors officers liability policy elsevier rights reserved
human communication covers two forms verbal nonverbal nonverbal communication indispensable inseparable part human interaction communication main part nonverbal communication body language includes posture gesture eye contact facial expression body language plays important role utterance meaning supplement accenting repetition substitute body language belongs part culture unavoidable body language misunderstanding since different meanings different culture background necessary master body language different cultures thesis focuses communicative functions body language perceptive cultural differences way people understand body language better improve communicationl
consumption energy large computing system important issue energy sources depleting fast also due deteriorating environmental conditions computational grid large heterogeneous distributed computing platform consumes enormous energy task execution energy aware job scheduling computational grid important issue addressed work tasks properly scheduled keeping optimal energy concern possible save energy consumed system task execution prime objective work schedule dependent tasks job grid nodes optimal energy consumption energy consumption estimated help dynamic voltage frequency scaling dvfs makespan optimizing energy consumption also taken care proposed model applied purpose therefore model named energy aware genetic algorithm eaga performance evaluation proposed model done using gridsim simulator comparative study existing models viz min min max min proves efficacy proposed model
study indicates analysis morphometric parameters help geographic information system gis would prove viable method characterizing hydrological response behaviour watershed also well observed remote sensing satellite data emerging effective time saving accurate technique morphometric analysis basin technique found relevant extraction river basin stream networks aster dem conjunction remote sensing satellite data landsat etm georeferenced survey indian toposheet study kanhar basin tributaries son river selected detailed morphometric analysis seven sub watersheds also delineated within basin calculate selected morphometric parameters morphometric parameters viz stream order stream length bifurcation ratio drainage density stream frequency form factor circulatory ratio etc calculated drainage area basin shows sub dendritic dendritic drainage pattern stream order basin mainly controlled physiographic lithological conditions area study area designated seventh order basin drainage density value increase stream length ratio lower higher order shows study area reached mature geomorphic stage
paper studies historical epistemological approaches followed historians theory elasticity authors chosen todhunter pearson love timoshenko truesdell perhaps important historians english language since second half nineteenth century shown historical purpose changed one historian next ranging history compilation known criticism evolution elasticity path progress investigated significant differences historians although overall sense confluence towards form truth relation history theory identified recurrent theme epistemology author although explicitly stated seen change following main trends times possible avenues research mentioned towards end
antiretroviral therapy art increasingly used hiv prevention tool administered uninfected people ongoing hiv exposure pre exposure prophylaxis prep infected people reduce infectiousness used modelling approach determine optimal population level combination art prep allocations required south africa maximize programme effectiveness four outcome measures new infections infection years death cost considered two different strategies allocating treatment one selectively allocates drugs sex workers one found low treatment availability prevention prep general population prep art sex workers key maximizing effectiveness higher drug availability art general population optimal south africa current level treatment availability using prevention effective reducing new infections infection years cost using treatment art general population best reduces deaths treatment levels meet unaids ambitious new target using almost treatment art general population best reduces four outcome measures considered
psychological science examines racial gender bias primarily located within social psychology tended discount ways race gender mutually construct lay conceptions racial gender discrimination tend see racism primarily afflicting men sexism primarily afflicting white women fact race gender interrelated work together intersectionally ignoring women experiences racial discrimination produces androcentric conceptions racisms words many definitions racial discrimination degree sexist goff similarly privileging experiences white women produces narrow definitions gender discrimination words many definitions gender discrimination degree racist serve reinforce current societal hierarchies psychological science sometimes appears reflect conceptions result social science principally responsible explaining individual level biases developed body research undervalue experiences non white women goff article examines features social psychological science research processes answer question suggested framing current psychological understanding racism extent sexist understanding sexism extent racist argue instruments much social psychological science uses measure racial gender discrimination may play role producing inaccurate understandings racial gender discrimination also present original experimental data suggest lay conceptions parallel social psychology biases lay persons also assuming racism black men sexism white women finally provide suggestions increase inclusivity psychology study discrimination well reasons optimism area
partnered adults tend lower risks depression single individuals parents commonly depressed non parents low testosterone men possibly women also greater risk depression large body research shown partnered parents lower testosterone single non parents cultural settings including drew large population representative cohort reproductive aged adults age years test hypotheses regarding intersections partnering parenting testosterone socio demographic characteristics depression outcomes men women depression prevalence vary based testosterone partnered fathers lower testosterone single never married divorced non fathers less commonly depressed single non fathers partnered mothers reduced testosterone compared never married partnered non mothers never married mothers higher depression prevalence elevated depressive symptomology compared partnered mothers differences largely accounted key health related covariates cigarette smoking bmi found significant three way interactions socioeconomic status ses testosterone parenting adults depression risks high testosterone high ses fathers lowest prevalence mild depression whereas low testosterone low ses non fathers highest compared mothers low ses low testosterone mothers elevated prevalence mild depression overall low ses high testosterone non mothers substantially elevated depression risks compared women suggest psychobiological profiles male low testosterone emerge variable psychosomatic psychosocial pathways net effect profiles depression influenced social partnering parenting status socioeconomic gradients cultural gender family life domains ecological lived environment particularly related low ses poverty contexts individuals find elsevier ltd rights reserved
background testosterone deficiency hypogonadism common among men undergoing haemodialysis clinical implications well characterized testosterone anabolic hormone induces erythrocytosis muscle synthesis hypothesized testosterone deficiency would associated low muscle mass physical inactivity higher dosages erythropoietin stimulating agents esa methods single center cross sectional study male haemodialysis patients none patients undergoing testosterone replacement therapy total testosterone measured serum body composition bioelectrical impedance analysis physical activity use pedometers assessed patients testosterone levels normal range considered hypogonadal results mean testosterone level patients hypogonadal hypogonadal patients older lower mean arterial blood pressure higher interleukin levels lower lean body mass higher fat body mass negative association testosterone normalized esa dose found uni multivariate regression analyses testosterone levels directly correlated lean body mass regardless confounders hypogonadal patients lower physical activity counterparts steps day relationship testosterone physical activity independent age comorbidities inflammatory markers dependent proportion muscle mass conclusion hypogonadism common male haemodialysis population associated higher esa doses reduced muscle mass lower physical activity link low testosterone levels physical inactivity may conceivably relate reduced muscle mass due inadequate muscle protein synthesis sociedad espanola nefrologia published elsevier espana
background disentangling impacts sex gender understanding male female differences increasingly recognised important aspect advancing research addressing knowledge gaps field work health however achieving goal secondary data analyses direct measures gender collected challenging study outlines development gender index focused gender roles institutionalised gender using secondary survey data canadian labour force survey using index examined distribution gender index scores among men women changes gender roles among male female labour force participants methods created labour force gender index lfgi using information four areas responsibility caring children occupation segregation hours work level education lfgi scores ranged higher scores indicating feminine gender roles examined correlations component measure total lfgi score using multivariable linear regression examined change lfgi score male female labour force participants results although women higher lfgi scores indicating greater feminine gender roles men women represented across range lfgi scores correlations indicated redundancy measures used calculate lfgi scores lfgi scores increased marginally men decreased marginally women however lfgi scores among women still points higher average men conclusions described applied method create measure gender roles using survey data direct measure gender masculinity femininity available measure showed good variation among men women responsive change time article concludes outlining approach use measure examine relative contribution gender sex differences health status outcomes men women
new application specific integrated circuit asic high speed charge time converter qtc iwatsu clc provides three channels consisting preamplifier discriminator low pass filter charge integration circuitry optimized waveform photomultiplier tube pmt asic detects pmt signals using individual built discriminators drives output timing signals whose width represents integrated charge pmt signal combined external input circuits composed passive elements qtc provides full analog signal processing detector pmts ready processing time digital converters tdcs high rate mhz signal processing achieved short charge conversion time baseline restoration circuits wide range charge measurements enabled offering three gain ranges maintaining short cycle time qtc chip test results show good analog performance efficient detection single photoelectron signal four orders magnitude dynamic range similar similar charge linearity charge resolution timing resolution test results ambient temperature dependence channel isolation rate dependence also meet specifications elsevier rights reserved
positive urgency tendency respond impulsively positive affective states linked many psychopathologies little known mechanisms underpinning form impulsivity examined whether positive urgency measure pum related higher scores performance based measures impulsivity cognitive control administered positive mood induction undergraduates completed self report pum several positive mood inductions behavioral measures impulsivity cognitive control pum scores significantly related poor performance antisaccade task measure prepotent response inhibition performance measures together existing literature findings implicate deficits response inhibition one mechanism involved emotion related impulsivity
many psychological disorders comprise seasonal component instance seasonal affective disorder sad characterized depression autumn winter hippocampal atrophy may underlie symptoms depression depressive like behaviors one goal study determine whether short days also induce structural changes hippocampus using photoperiod responsive rodents siberian hamsters exposure short days increases depressive like responses increased immobility forced swim test hamsters male hamsters housed either short long days weeks tested forced swim test brains removed processed golgi impregnation hpa axis function may account photoperiod related changes depressive like responses thus stress reactivity assessed another cohort photoperiod manipulated animals short days reduced soma size dendritic complexity region photoperiod induce gross changes stress reactivity acute stressor disrupted typical nocturnal peak cortisol concentrations data reveal immobility induced exposure short days correlated reduced cell complexity perhaps connectivity study first investigate hippocampal changes context short day induced immobility may relevant understanding psychological disorders seasonal component elsevier inc rights reserved
current study examines prison programming availability participation gender national level authors build upon previous literature using national level data something done limited cases previously main concern study gender effects programming availability participation corrections field undergone major changes regard population trends fiscal constraints policies research last decades without large scale examination effects changes programming across united states study multiple types programming areas examined results indicated often female prisons prisons housing females likely offer programs mental health options women likely participate many programming options compared male prisons men respectively discuss possible reasons implications future research
human amnion epithelial cells haecs shown possess potent immunomodulatory properties across number disease models recently reported haecs influence macrophage polarization activity step dependent regulatory cells study aimed assess effects haec derived proresolution lipoxin lxa cell macrophage neutrophil phenotype function acute phase bleomycin induced lung injury using cbl mice administered million haecs intraperitoneally hours bleomycin challenge outcomes measured days haec administration resulted significant changes cell macrophage dendritic cell monocyte macrophage infiltration phenotypes endogenous levels lipoxygenases lxa lipoxin receptor fpr elevated haec treated animals furthermore showed effects haecs macrophage phagocytic activity cell suppression lxa dependent whereas inhibition neutrophil derived myleoperoxidase haecs independent lxa study provides first evidence lipid based mediators contribute immunomodulatory effects haecs supports growing body evidence lxa proresolutionary lung injury discovery lxa dependent communication haecs macrophages cells neutrophils important understanding haec biodynamics would expected inform future clinical applications
yeasts water sources associated diseases ranging superficial mucosal infections life threatening diseases aim study determine water quality well diversity antifungal susceptibility yeasts two rivers yeast levels physicochemical parameter data analyzed principal component analysis determine correlations physico chemical data yeast levels yeast morphotypes identified biochemical tests rrna gene sequencing disk diffusion antifungal susceptibility tests conducted physico chemical parameters water within target water quality range twqr livestock farming irrigational use total dissolved solids nitrates within twqr yeast levels ranged cfu non pigmented ascomycetous yeasts isolated saccharomyces cerevisiae candida glabrata frequently isolated several opportunistic pathogens also isolated large number isolates resistant azoles especially fluconazole also antifungal classes candida species resistant almost antifungal classes water sources used recreation religious well watering livestock irrigation particular concern direct contact individuals opportunistic yeast especially immune compromised resistance yeast species antifungal agents health concern
oscillometric measurement widely used estimate systolic blood pressure sbp diastolic blood pressure dbp paper propose deep belief network dbn deep neural network dnn learn complex nonlinear relationship artificial feature vectors obtained oscillometric wave reference nurse blood pressures using dbn dnn based regression model dbn dnn powerful generative network feature extraction address stick local minima special pretraining phase therefore model provides alternative way replacing popular shallow model based apply dbn dnn based regression model estimate sbp dbp however small amount data samples enough train dbn dnn without overfitting problem reason use parametric bootstrap based artificial features used training samples efficiently learn complex nonlinear functions feature vectors obtained reference nurse blood pressures far know one first studies using dbn dnn based regression model estimation small training sample available dbn dnn based regression model provides lower standard deviation error mean error mean absolute error sbp dbp compared conventional methods
piezoelectric energy harvesters generate electrical power ambient mechanical vibrations making vibrations viable energy source powering wireless sensor identifier nodes order harvest appreciable amount power piezoelectric devices typically inserted high mechanical resonant structures significantly limit harvesting bandwidth dynamic active energy harvesting method proposed way widen bandwidth resonant piezoelectric energy harvesters however autonomous design yet demonstrated paper demonstrates first autonomous implementation method accomplished use resonant inverter topology combination low power analog control circuit design reduces computational demand microcontroller experimental results using mide volture piezoelectric device show harvested power twice adaptive rectifier method results include previously ignored loss mechanisms control losses gating losses phase detection losses making system first autonomous energy harvesting system kind
two centuries solutions differential equations obtained either analytically numerically based typically well behaved forcing boundary conditions well posed problems changing paradigm fundamental way establishing interface probabilistic machine learning differential equations develop data driven algorithms general linear equations using gaussian process priors tailored corresponding integro differential operators observables scarce noisy multi fidelity data forcing solution required reside domain boundary resulting predictive posterior distributions quantify uncertainty naturally lead adaptive solution refinement via active learning general framework circumvents tyranny numerical discretization well consistency stability issues time integration scalable high dimensions elsevier inc rights reserved
overconfidence false memories often found patients schizophrenia healthy participants high levels schizotypy indicating impairment meta cognition within memory domain general cognitive control suggested modulated natural fluctuations oestrogen however whether oestrogen exerts beneficial effects meta memory yet investigated present study sought provide evidence high levels schizotypy associated increased false memory rates overconfidence false memories processes may modulated natural differences estradiol levels using deese roediger mcdermott paradigm found highly schizotypal participants high estradiol produced significantly fewer false memories low estradiol difference found within low schizotypy participants highly schizotypal participants high estradiol also less confident false memories low estradiol low schizotypy participants high estradiol confident however differences approached significance findings suggest beneficial effect estradiol memory meta memory observed healthy participants specific highly schizotypal individuals might related individual differences baseline dopaminergic activity elsevier ireland ltd rights reserved
waste stabilisation ponds wsps used worldwide wastewater treatment throughout operation require periodic sludge surveys sludge accumulation wsps impact performance reducing effective volume pond altering pond hydraulics wastewater treatment efficiency traditionally sludge heights thus sludge volume measured using low resolution labour intensive methods sludge judge white towel test sonar device readily available technology fitted remotely operated vehicle rov shown improve spatial resolution accuracy sludge height measurements well reduce labour safety requirements coupled dedicated software package profiling several wsps shown rov autonomous sonar device capable providing sludge bathymetry greatly increased spatial resolution greatly reduced profiling time leading better understanding role played sludge accumulation hydraulic performance wsps high resolution bathymetry collected used support much detailed hydrodynamic assessment systems low medium high accumulations sludge results modelling show hydraulic performance influenced sludge accumulation also spatial distribution sludge plays critical role reducing treatment capacity systems range ponds modelled reduction residence time ranged pond uniform sludge distribution reduction pond highly channelized flow combination high resolution measurement sludge accumulation hydrodynamic modelling help development frameworks wastewater sludge management including development reliable computer models could potentially wider application monitoring small medium water bodies channels recreational water bodies commercial ports elsevier ltd rights reserved
oral contraceptive pills ocps continue commonly used form prescription contraceptives used adolescents united states proper use oral contraceptives provide safe effective birth control broad categories ocps include progestin pills pops combined oral contraceptive pills cocs certain types progestins potent antiandrogenic properties effective treating acne hirsutism polycystic ovary syndrome article reviews types ocps discusses risks benefits ocps provides guidance choose beneficial appropriate ocp individual adolescent patients
emergence hardware multithread architectures increased performance applications however traditional architectures suitable real time operating systems performance oriented scheduling algorithm may conflict rtos software scheduling letter presents shadows portable architecture provides unified hardware software scheduling bringing benefits rtos domain show tightly coupled real time compliant hardware integration achieves throughput benefits maintaining rtos scheduling policy intact increasing predictability rtoses solution shows average speed ups times native versions low area usage performance overhead ratio due minimal cost extra slices per hardware supported thread work surpasses related work providing complete agnostic hardware solution independent specific rtos
safe continuous operation chemical plants important issue sustainability chemical enterprises control prevention degradation damage components used chemical plants indispensable purpose although varied types material stainless steels based alloys reactive metals use control phenomena plants various cases degradation damage actually experienced accidents caused degradation occasionally reported order prevent uncontrolled degradation thought necessary predict likelihood degradation materials actual operating conditions use compatible materials detect degradation inspection advance apply proper countermeasures based realistic life estimation plant concerned order follow processes properly extensive accumulation orderly organization knowledge mechanisms degradation damages characteristics materials inspection technics methods plant life estimation thought vital importance stainless steel commonly used material chemical plants sufficient accumulation information knowledge stainless steel components used considered important subject prevent degradation damage chemical plants paper enumerates characteristics commonly encountered modes degradation stainless steel components chemical plants presents cases degradation damage stainless steel equipment plants together control measures required prevent degradation present day problems materials engineering relating reliability chemical plants countermeasure degradation damage also presented
notion internet things iot means things global network interconnected accessed wireless sensor network wsn one important applications notion widely used nearly scopes hsieh presented improved authentication scheme wsns several weaknesses including session key lack mutual authentication insider attack line guessing attack user forgery attack sensor capture attack avoid weaknesses present new authentication scheme also wsns employ random oracle model show formal proof use protocol analyzing tool proverif list formal verification process compared recent schemes wsns via aspects security properties proposed scheme overcomes common problems fits security properties iot
evidences suggest obesity impairs effectiveness tnf inhibitors examined impact body mass index bmi clinical effectiveness abatacept rheumatoid arthritis patients pooled analysis prospective cohorts patients patients available bmi included study primary endpoint drug retention abatacept different bmi categories multivariable cox regression used estimate hazard ratios hrs drug discontinuation secondary endpoint eular lundex response rates months patients initiating therapy abatacept classified obese obese patients functional disability less often positive median abatacept retention time years obese patients compared years non obese patients risk abatacept discontinuation significantly different overweight obese compared normal weight patients rheumatoid factor positivity reduced risk abatacept discontinuation previous biologic therapy positively associated drug interruption hrs increasing line treatments obese non obese patients attained similar rates eular lundex clinical response months drug retention clinical response rates abatacept seem decreased obesity patients
male sex long argued strong risk factor arterial hypertension noteworthy available data support negative impact low testosterone male cardiovascular health objective study designed assess characteristics circadian blood pressure arterial stiffness hypertensive men without testosterone deficiency materials methods total male hypertensive patients aged years screened androgen deficiency symptoms via male ropause symptoms self assessment questionnaire massq subjects suspected low testosterone level recruited study subsequent total testosterone measurement monitoring carried participants aortic stiffness assessed using bplab vasotens system cuff based oscillometry method results patients biochemically confirmed low testosterone level total score massq group significantly higher compared patients normal testosterone decreasing concentration age detected low group characterized significantly higher values systolic blood pressure sbp pulse pressure values lower testosterone appears associated prevalence non dipper pattern results multiple regression analysis revealed relationship plasma testosterone levels sbp values study groups relationship testosterone dbp values significant significant relationship also found group pwv conclusion study revealed high prevalence androgen deficiency among hypertensive middle aged men patients characterized higher values compared normal levels age range low concentration may considered also contributor increased arterial stiffness hypertensive males
molecular diagnostic testing presents new challenges information management yet sufficiently addressed currently available information systems molecular laboratory challenges relate unique aspects molecular genetic testing molecular test ordering informed consent issues diverse specimen types encompass full breadth specimens handled traditional anatomic clinical pathology information systems data structures data elements specific molecular testing varied testing workflows protocols diverse instrument outputs unique needs requirements molecular test reporting nuances related dissemination molecular pathology test reports satisfactorily addressing needs molecular test data management laboratory information system designed unique needs molecular diagnostics presents compelling reason migrate away current paper spreadsheet information management many molecular laboratories currently use paper reviews issues challenges information management molecular diagnostics laboratory
background purpose study examine contribution cognitive functioning arithmetic problem solving explore cognitive profiles children attention deficit hyperactivity disorder adhd mathematical learning disabilities mld methods sample made total students grade organized three adhd mld typically achieving control group assessment conducted two sessions pass processes arithmetic problem solving evaluated results adhd group performance planning attention worse control group children mld obtained poorer results control group planning simultaneous successive processing executive processes predicted arithmetic problem solving adhd group whereas simultaneous processing unique predictor mld sample conclusions children adhd mld showed characteristic cognitive profiles groups problem solving performance predicted cognitive functioning elsevier ltd rights reserved
paper presents optimization based design methodology fully differential amplifiers fdas including effects real common mode feedback cmfb circuits constraints design flow sizing procedure performed separately main amplifier cmfb circuit reducing number free variables exploring design space efficient way also methodology employed design single two stages fdas whereas second pole compensation scheme necessary order validate proposed methodology two stage fully differential amplifier capacitor feed forward ncff compensation technique designed cmos technology power supply presented results also include pole zero pair mismatch analysis proposes solution order compensate generated pole zero doublet might affect performance amplifier show approach reduces overall static power consumption satisfying design specifications
background purpose study identify risk factors outcome implications day hospital readmission lung transplant recipients methods conducted retrospective cohort study lung transplant cases single high volume lung transplant program january march demographic health data reviewed patients risk factors day readmission defined readmission within days discharge index lung transplant hospitalization modeled using logistic regression selection parameters backward elimination results sample comprised patients excluding scheduled readmissions hospital deaths overall day readmission rate readmission rates similar across different diagnosis categories procedure types univariate analysis post operative complications predisposed day readmission included pneumonia infection atrial fibrillation kaplan meier analysis multi variate regression modeling assess readmission predictor long term outcomes showed day readmission significant predictor worse survival lung recipients conclusions occurrence least post transplant complication increases risk day readmission lung transplant recipients patient population day readmission predispose adverse long term survival quality indicators day readmission may needed assess hospitals perform lung transplantation international society heart lung transplantation rights reserved
preclinical research documents aside primary secondary reinforcing effects nicotine intake nicotine also acutely enhances reinforcing efficacy non drug reinforcers rewards study effects humans largely overlooked recent findings suggest may clinical implications fully understanding persistence tobacco dependence overview first outlines topic notes recent human studies indirectly addressing nicotine effects related responses subjective ratings explaining findings directly confirm enhancement behavioral reinforcement per due nicotine methodology used subsequently presented studies described demonstrating studies specifically demonstrate enhancement reinforced responding non drug rewards main section focuses limited controlled research date directly assessing nicotine acute reinforcement enhancing effects humans particularly relates reinforced behavioral responding non drug rewards non human animal models detailing existing human studies address potential consequences effects dependence tobacco cessation efforts suggest directions future research research indicates nicotine per increases responding humans reinforced rewards auditory stimuli via music visual stimuli via video perhaps others money reinforcement enhancing effects smokers due dependence withdrawal relief restored small amount nicotine similar smoking lapse including cigarettes non tobacco nicotine product future clinical research examine factors determining types rewards enhanced nicotine consequences loss nicotine effects quitting smoking potential individual differences effects possibility nicotine via nicotine replacement therapy non nicotine quit medications may attenuate loss effects upon quitting study humans nicotine reinforcement enhancing effects may provide complete understanding smoking persistence added mechanisms cessation medication efficacy
availability water community based water harvesting structure intensified agriculture improved livelihood surveyed beneficiary households shivalik foothills india introduction makowal type water harvesting system mtwhs farmers kharif rabi season growing crops introduction mtwhs corresponding values improved respectively thus increasing cropping intensity introduction mtwhs enabled farmers take paddy agro forestry kharif vegetables fodder rabi season increase cultivated area due mtwhs tune kharif rabi increase crop productivity ranged kharif rabi season better availability irrigation changed varietal spectrum favour hybrids high yielding varieties farmers started adopting improved agronomic practices targeting better input use efficiency mtwhs produced positive impact farm crops dairy agro forestry sources income reduced relative dependence farm activities labour community forest area etc earnings system brought drinking water close hutments rural women thus reducing drudgery saving time general rainwater harvesting forest watersheds resulted quantum jumps crop milk production acted catalyst tie economic interest communities along forest protection
article family polynomial estimators estimation linear system response weakly non linear systems examined regarding estimation errors applicability estimator introduced extension measurement setups input output noise shown results obtained polynomial estimators related parameters volterra models bias variance tradeoff estimation error derived methods obtaining minimum error presented
paper demonstrate ability derivative driven monte carlo estimator accelerate propagation uncertainty two high level non linear finite element models use derivative information amounts correction standard monte carlo estimation procedure reduces variance certain conditions express finite element models variational form using high level unified form language ufl derive tangent linear model automatically high level description use efficiently calculate required derivative information study effectiveness derivative driven method consider two stochastic pdes one dimensional burgers equation stochastic viscosity three dimensional geometrically non linear mooney rivlin hyperelastic equation stochastic density volumetric material parameter results show problems first order derivative driven monte carlo method around one order magnitude faster standard monte carlo method cost one extra tangent linear solution per estimation problem find similar trends comparing modern non intrusive multi level polynomial chaos expansion method parallelise task repeated forward model evaluations across cluster using ipyparallel mpipy software tools complete working example showing solution stochastic viscous burgers equation included supplementary material published elsevier
paper discusses discrete time loop shaping algorithm servo enhancement multiple wide frequency bands design considerations motivated large class practical control problems vibration rejection active noise control periodical reference tracking well recent novel challenges demand new design servo technologies pseudo youla kucera parameterization scheme proposed using inverse system model bring enhanced control selected local frequency regions design methodologies created control waterbed amplifications come fundamental limitations feedback control finally simulation experimental verification conducted precision control semiconductor manufacturing elsevier ltd rights reserved
paper explains software architecture planned designed implemented help support elearning activities within virtual laboratory inside second life virtual world delves problems related kind systems architectures detects possible benefits could provide elearning processes paper shows software engineering principles procedures applied order solve problems data gathering virtual worlds data analytics information related interaction user environment applied enhance students learning process teachers assessment learning process paper also shows software product resulting engineering process well outcomes application solution real context two academic years involving postgraduate students subjects pharmacy quality assurance end paper explain considerations knowledge retrieved experience focusing utility learning point view innovation possible future work could done improve solution implemented
although subset iraq afghanistan veterans show aggression toward others return home military service little known protective mechanisms could bolstered prevent violence national longitudinal survey conducted using random sample veterans served operation iraqi freedom operation enduring freedom one thousand ninety veterans states representing military branches completed waves data collection year apart retention rate final sample resembled military post terms age sex ethnicity geography service branch protective mechanisms socioeconomic money cover basic needs stable employment psychosocial resilience perceiving control one life social support physical healthy sleep physical pain domains examined found protective mechanisms predicted decreased aggression violence follow particularly among higher risk veterans multivariable analyses confirmed protective mechanisms lowered violence interaction risk factors study identifies protective mechanisms related decreased community violence veterans indicates rehabilitation aimed improving socioeconomic psychosocial physical well potential promise reduce aggression violence among veterans returning home military service
data hiding concept steganography provide security facilitate safe exchange important information digital world concept used various multimedia text image video audio acting cover medium carry one way exchange two way exchange secret information presented paper focusses kind steganography uses audio carrier concept steganography act encoding mystery data invisible manner steganography along cryptography add step futher security hiding cipher text manner middle man unaware secret message concealed cipher text generated encryption creates suspects steganography creates environment looks like normal behavior hiding suspect nature cipher text thus making secure audio steganography investigation concealing mystery content audio data host audio paper presents execution two level security end user information associating two fields system security cryptography steganography concept index based chaotic sequence used encryption carries two approaches make cryptanalysis steganalysis furthermore difficult compare simple lsb method first approach encrypting secret text using index based chaotic sequence proposed approach secure strong robust giving security secret information second approach hiding output generated first approach using concept lsb xor method gives extra level security creating minimum distortion host audio file simultaneously maintaining high embedding capacity
doubly salient mechanical structure switching characteristics switched reluctance motor srm led torque ripple low dynamic performance problems using conventional control algorithm speed control method view fractional pid control algorithm strong robustness advantage fuzzy control depend precise mathematical model paper proposed control algorithm based fuzzy fractional order pid torque control algorithm basis fuzzy rules using control algorithm adaptive srm torque control using speed deviation deviation changing rate input srm turn torque ripple smaller changing proportional coefficient integral order differential order fuzzy inference adaptive fractional order pid controller simulation results indicate control algorithm feasible torque ripple switched reluctance motor smaller dynamic response better
background purpose study determine total serum immunoglobulin ige could predict monosensitization compared polysensitization patients allergic rhinitis methods retrospective study cohort patients underwent allergy testing differences total ige level unsensitized monosensitized polysensitized subjects calculated pearson correlation coefficient calculated determine whether relationship total ige level number positive allergen sensitizations addition allergen sensitization class calculated allergen sensitization totaled patient pearson correlation coefficient calculated determine relationship total ige level weighted allergen sensitization class results patients monosensitized compared patients polysensitized monosensitized patients almost sensitized one dust mites total ige higher polysensitized patients compared monosensitized compared controls pearson correlation coefficient total ige number positive allergen sensitizations pearson correlation coefficient total ige allergen class weighted sensitizations conclusion ige level used predict monosensitization polysensitization moderate correlation total ige sensitization number positive allergen sensitizations well allergen class weighted sensitizations ars aaoa llc
temporal urinary proteome examined groups individuals order determine temporal stability diverse individuals apparently good kidney health groups consisted healthy volunteers zero time months kidney donors surgery recipients immediately surgery successful kidney transplant recipients month years transplant proteins detected reverse phase extraction urine followed maldi tof profile itraq analysis unusual components maldi tof profiles found transplant subjects occurred human neutrophil defensins beta microglobulin peaks also quite intense among kidney donors following surgery peaks transplant recipients associated higher serum creatinine several additional proteins detected itraq regulated manner correlated closely overall despite large differences protein composition different transplant recipients remarkable stability individual detected either maldi tof itraq analyses results suggested within limits stability profile components may important protein content definition kidney health longitudinal study urinary proteins kidney recipients may demonstrate instability sensitive biomarker adverse kidney health
chapter integrates literature expectations toward perceptions media author argues expectations perceptions important explanatory variables selection effects media chapter brings together ideas uses gratifications tradition research hostile media third person perceptions media credibility research model uses perceptions media model audience perceptions introduced important antecedents media use well future expectations toward media chapter emphasizes importance media perceptions effects limited attitudinal level also regard political participation voting behavioral responses chapter concludes call scholarly efforts linking uses perceptions media political communication research
earlier remote password authenticationschemes required service providing server authenticate legitimate userfor remote login however traditional schemes useful multi server architecture multiple user ids passwords paper present remote password authentication scheme multi server architecture robust improved network security password authentication system trainedclassification system based svm scheme users remember ownidentity password choices various server login filled registration user choose hispassword furthermore system require overhead password verification table dynamic nature also withstand replay attack masquerading
small modular reactors new generation low energy output low hazard compact modular nuclear reactors output mwe per unit integration inherent passive safety measures site construction higher fuel burn rates promise safer lower waste reduced risk venture earlier investment returns investors compared large scale nuclear power plants moreover non proliferation enhanced use small quantities non weapons grade nuclear fuel introduction alternative potential fuels thorium fuel waste actinides paper reviews state art discusses economic feasibility small modular reactors focus levelised cost electricity economy scale limitations country wishing embark nuclear energy deployment concerns regarding integration small modular reactors existing electrical grids countries various levels nuclear power production capability also discussed suggestions alternatively calculating cost small modular reactors legislation route also provided along pros cons economics safety small modular reactor deployment country new nuclear power
disease discovery important task medicinal science computer presented early disease discovery medical science image processing techniques paper devoted exploration brain images early detection parkinson disease brain images analyzed extract gabor features also shown models created gabor features outperform ones created without gabor features experimental results conducted dataset brain images individuals diagnosed real cases parkinson diseases expert clinicians three special experimentations conducted paper
background aims early adverse life events eals relevant irritable bowel syndrome adulthood maternal separation one eals proved induce visceral hypersensitivity adult rats however effect visceral hypersensitvity post weaning period adulthood remains unknown methods one hundred ten neonatal sprague dawley rats randomly divided groups rats group exposed hours daily postnatal day pnd normal control group remained undisturbed visceral sensitivity determined measuring visceromotor response colorectal distention pnd anxiety like behaviors measured open field test results compared rats rats showed significant visceral hypersensitivity post weaning period adult proportion visceral hypersensitive rats decreased age female group male group relative vmr ratio pnd higher pnd pnd rats showed decreased ability movement exploration novel environment post weaning period obesity prepubertal period anxiety like behaviors adulthood conclusions significantly affect visceral sensitivity behaviors rats different age stages especially post weaning period visceral hypersensitivity rats pronounced post weaning period slightly restored adults thus visceral hypersensitivity post weaning period might play meaningful pathophysiologic role formation adult irritable bowel syndrome
recent years application laser point cloud data increased dramatically efficiently store fast process data becomes important research direction present point cloud data contain wealth geographic information belonging category spatial data traditional relational databases relatively weak massive spatial data storage processing application non relational databases provides new perspective study fact sharding technology solution database level extension thesis sharding cluster mongodb established distributed environment distributed storage spatial query mapreduce operation test numerous laser point cloud data implemented scope sharding hash based sharding completely reflects huge advantages mongodb distribution storage processing spatial data
paper provides depth understanding social dynamics form kinship ties matrilineal societies unpacks gender roles relationships community level understand social structures created pattern relations enhance hinder coping initiatives lake recessions lake chilwa socio ecological system using qualitative quantitative methods including depth interviews focus group discussions fgd household questionnaires paper provides insights people lake chilwa social ecological system prepare cope lake chilwa water recessions capitalising social networks findings shown lake recessions poor households lake chilwa socio ecological system cushioned fellow households lineage networks strong tradition secured kinship ties generic term mwambo wathu tradition embraces group formative norms enforced via series rules rituals based matrilineal system women strong rights land allocation use female sorority group mbumba stable great deal reciprocity food redistribution among households self organization provides deeper meaning people assimilate dynamics affecting social natural environments specifically findings provide evidence households communities livelihoods africa reconstructed natural resources fluctuate elsevier ltd rights reserved
network intrusion detection systems nidss always designed enhance improve network security issue detecting identifying assessing reporting unauthorized illegal network connections activities purpose research improve existing anomaly based intrusion detection abid method using means clustering technique maximize detection rate accuracy minimizing false alarm problem outliers may disturb means clustering process might avoided clustering process mixing normal data make nidss become less accurate thus research aims improve performance abid systems balance loss information ignored data clustering integrated machine learning algorithm using means clustering discretization technique naive bayes classifier kmc nbc proposed iscx intrusion detection evaluation dataset outcome depicts proposed method generates better detection rate accuracy respectively reduces false alarm better efficiency seconds time taken build model
full scale fatigue testing part certification process large wind turbine blades testing usually performed flapwise edgewise axes independently new method resonant fatigue testing developed flapwise edgewise directions tested simultaneously thus also allowing interactions two mutually perpendicular loads investigated method evaluated comparing palmgren miner damage sum around cross section selected points along blade length results simulated service life specified design standards testing bending moments point generated using wind turbine simulation software test loads designed cause amount damage true service life mode shape blade tuned optimising position excitation equipment bending moment distribution close possible target loads loads converted strain time histories using strength materials approach fatigue analysis performed results show bending moment distribution correct along length blade dual axis resonant testing tests blade much thoroughly sequential tests flapwise edgewise directions approach shown representative loading seen service thus contribute potential reduction weight wind turbine blades duration fatigue tests leading reduced cost
available data support contribution neurodevelopmental neurodegenerative factors etiology schizophrenia sch bipolar disorder note one important issue current psychiatric research identify specific factors contribute impaired brain development neurodegeneration sch especially factors alter normal brain development physiological aging process hypothesis specific damages taking place precise brain development stages associated future sch onset neurodegeneration consists acceleration brain aging sch onset support hypothesis results present narrative mini review shows neurodevelopmental damages generally contribute neuropsychiatric syndromes hypothyroidism treponema pallidum specifically associated adult sch toxoplasma substance abuse particularly happen specific stages brain development hand cognitive impairment brain changes associated long duration sch look like happens aging memory executive domains prefrontal cortex implicated aging sch progression future research explore possible validity etiological model sch
opportunities challenges related internet use continue grow well social concern around problematic internet use piu online risky behaviors intensive use internet mainly among adolescents aim study conduct general screening piu large sample school based adolescents spain providing updated prevalence data piu different online risky practices well rates internet social network use differences problematic nonproblematic users explored terms demographics parental control motivations using association piu involvement online risky behaviors also analyzed well role intensive use findings show global prevalence piu among spanish adolescents percent although higher among females late teens intensive users without parental control logistic regression confirmed piu intensive use risk factors involved online risky behavior tentative explanation could common deficit personal social skills underlying piu intensive use online risky practices perspective value based education life skills training best way reach responsible sensible use internet among adolescents parents schools institutions adolescents called upon actively engage facing problem
purpose study assess value spatial heterogeneity somatostatin receptor ssr volume quantified asphericity asp predict response peptide receptor radionuclide therapy prrt patients metastatic gastroenteropancreatic neuroendocrine neoplasms gep nen june may patients suffering gep nen underwent pretherapeutic dtpa octreotide scintigraphy octreoscana prior dota tyr octreotate dotatate prrt enrolled retrospective evaluation ssr expression nen patients qualitatively quantitatively assessed using krenning score metastasis liver uptake ratio ratio asp baseline response prrt evaluated based lesions classified responding lesions non responding lesions nrl month follow ups values krenning score ratio asp response prediction compared using mann whitney test kruskal wallis test receiver operating characteristic roc curves seventy seven metastases liver lymph node bone pancreas showed ssr expression higher asp level significantly associated poorer response time points roc analyses revealed highest area curve auc discrimination nrl asp months auc months auc followed krenning score auc auc respectively ratio auc auc optimal cutoff value asp sensitivity specificity asphericity ssr expressing lesions pretherapeutic single photon emission computed tomography integrated computed tomography spect promising parameter predicting response prrt gastroenteropancreatic neuroendocrine neoplasms
background smoking important risk factor mental health related problems numerous studies supported directional association cigarette smoking depression despite advances understanding comorbidity problems effective psychological treatment simultaneously targets smoking depressive symptomatology remains unclear objective study assess effectiveness cognitive behavioral intervention smoking cessation components behavioral activation managing depressed mood method single blind three arm superiority randomized controlled trial proposed participants smokers years old smoke least cigarettes per day participants randomized one three conditions using allocation ratio standard cognitive behavioral smoking cessation treatment standard cognitive behavioral smoking cessation treatment plus behavioral activation three month delayed treatment control group primary outcome measures biochemically verified point prevalence abstinence carbon monoxide expired air significant change baseline depressive symptoms end treatment month follow discussion study aims assess efficacy cognitive behavioral intervention behavioral activation components smoking cessation depressive symptoms compared standard cognitive behavioral intervention quit smoking relation depressive symptoms even subclinical levels quitting smoking difficulties well known expect intervention allow obtaining higher abstinence rates lower relapse rates mood improvement
european union working strategies order increase energy efficiency buildings useful solution identify energy performance buildings energy performance certificate epc provides information comparison buildings different architectural typology shape design technology geographic location however tool assess real energy consumption building always take account impact environment work two different types analysis carried one based energy efficiency one based environmental impact analyses applied standard building set three different italian locations purpose obtaining cross related information evaluation results interventions parameters walls insulation windows frame filler gas insulated glazing identified order improve energy behavior building acceptable environmental impact aim paper propose methodology integrates epc green building rating systems leading conscious choice retrofit interventions compromise energy performances environmental impact
background individuals autism spectrum disorder asd experience marked challenges social function definition modifiable predictors social functioning asd identified extant research study hypothesized deficits social cognition motor function may help explain poor social functioning individuals asd method cross sectional data individuals asd without intellectual disability ages used assess relationship social cognition motor function social functioning results results hierarchical multiple regression analyses revealed greater social cognition motor function significantly associated better social functioning controlling sex age intelligence quotient post hoc analyses revealed better performance second order false belief tasks associated higher levels socially adaptive behavior lower levels social problems conclusions findings support development testing interventions target social cognition order improve social functioning individuals asd interventions teach generalizable skills help people asd better understand social situations develop competency advanced perspective taking potential create durable change effects applied wide varied set situations simply prescribed set rehearsed situations published elsevier ltd
paper describes rapid algorithm deployment platform smart grid research accounting complex interplay power system dynamics communication delays network means rapid code deployment algorithm design improve evaluation smart grid control schemes impact grid power quality novel approach bridges gap implementation highly realistic multi timeframe simulations expensive hardwired deployment architecture behavior platform presented one specific demand response algorithm namely dual decomposition large numbers distributed agents efficiently managed employing fipa compliant agent management specification ams directory facilitator functionalities well efficient sql database monitoring logging scheme architecture deployed actual laboratory setup virtual opal environment simulations results show system latency computational load increase linearly increasing numbers distributed agents novel approach provides realistic pragmatic solution evaluating distributed applications grid management market applications advanced monitoring power quality requirements
multiple kernel learning mkl algorithms proposed address problems associated kernel selection kernel based classification algorithms using group kernels rather one single kernel mkl algorithms aim provide better classification efficiency paper presents new similarity based mkl algorithms classify remote sensing images algorithms find optimal combination kernels maximizing similarity combination kernels ideal kernel framework initially introduced three similarity measures used kernel alignment norm kernel difference hilbert schmidt independence criterion proposed solve optimization problems mkl algorithm associated similarity measure adopting heuristic convex optimization methods performances proposed algorithms compared single kernel support vector machines well mkl algorithms classifying features extracted high resolution hyperspectral images results demonstrated similarity based mkl algorithms performed better algorithms especially optimization problems solved using convex optimization methods training samples available moreover optimization problems algorithms solved using heuristic optimization methods able yield acceptable performances faster mkl algorithms
blood plasma contains four biologically important proteolytic cascades probably evolved ancestral gene part may explain cascade similar initiating trigger followed sequential cascade like downstream enzymatic activation pattern four cascades complement system blood clotting cascade fibrinolytic system kallikrein kinin system although much written interplay enzymatic cascades cross talk complement kinin generating systems become particularly relevant interaction results generation nascent molecules significant impact various inflammatory diseases including angioedema cancer review focus consequences interplay two systems highlighting role novel molecular link called gcqr although protein first identified receptor recognized multiligand binding cellular protein serves receptor also high affinity binding site high molecular weight kininogen factor xii fxii inflammatory sites atherogenic factors immune complexes pathogens activate endothelial cell procoagulant proinflammatory surface two pathways activated generate vasoactive peptides contribute various ways inflammatory processes associated numerous diseases importantly since recent observations strongly suggest important role pathways cancer focus growing tumor cluster employ byproducts derived two activation systems ensure survival growth also escape distal sites colonization
precise estimation absolute risk cvd events necessary making treatment recommendations patients number multivariate risk models developed estimation cardiovascular risk asymptomatic individuals based upon assessment multiple variables due inherent limitation risk models several novel risk markers including serum biomarkers studied attempt improve cardiovascular risk prediction beyond established risk factors review discuss role underappreciated biomarkers red cell distribution width rdw cystatin cysc homocysteine hcy well imaging biomarkers cardiovascular risk reclassification highlight utility additional source information patients intermediate risk
article aims various benefits modular green roof technology nowadays smart solutions green roofs popular ecological technical economic benefits esthetic qualities green roofs used residential commercial govemment public buildings innovative energy efficient construction technologies bring great benefit ecology help relief heat island effect purpose research provide effective apparatus method green roof system principal results research focused adjusting optimal physical parameters green roof modules friendly environmental green roof technology oriented policy sustainable development protection urban ecology authors published elsevier ltd
purpose practical control system problems state variables system often available measureable due technical economical constraints cases observer based controller design problem involved using available information inputs outputs reconstruct unmeasured states desirable wide investigated many practical applications however investigation discrete time singular markovian jumping system far paper aims consider observer based control problem discrete time singular markovian jumping system provides set easy used conditions proposed control law design methodology approach according connotation separation principle extended linear systems mode dependent observer state feedback controller designed carried independently via two sets derived necessary sufficient conditions terms linear matrix inequalities lmis findings set necessary sufficient conditions admissibility analysis problem related discrete time singular markovian jumping system derived doctrinal foundation proposed design problems amode dependent observer controller systems could designed via two sets strictly lmi based synthesis conditions research limitations implications proposed method applied discrete time singular markovian jumping systems transition probability rather ones practical implications formulated problem proposed methods extensive applications various fields power systems electrical circuits robot systems chemical systems networked control systems interconnected large scale systems take robotic networked control systems example recognized variance phenomena derived network transmission packets dropout loss disorder suitable modeling system markovian jumping modes dynamics robot systems described singular systems addition packets dropout loss might result unreliable transmission signals motivates observer based control problem originality value resultant conditions analysis synthesis problems discrete time singular markovian jumping system necessary sufficient formed strict lmis used implemented easily via matlab toolbox
paper presents harmonics improvement converter based line frequency inverter domestic lighting loads harmonics problem power electronics converters new phenomenon decade succeeded effecting power output also recognized problem would destabilize reliability power system overcome problem design suitable filter must implemented project low pass filter chosen reduce harmonics system get power output input voltage battery power capacity chosen input voltage stepped using push pull converter voltage regulator circuit installed regulate voltage microcontroller chip picfa used main control unit project capability generate pulse width modulation pmw signals drive mosfet turn inverted using line frequency inverter bulb power capacity used output lighting loads
cpg oligodeoxynucleotide cpg odn reported protect airway hyper responsiveness also known potent vaccine adjuvant anti tumor therapy little known effect cpg odn mice radiation induced lung fibrosis rilf common late stage form tissue damage occurs thorax radiotherapy evaluated immunomodulatory effects cpg odn development rilf mice divided four groups single dose whole thorax cpg intraperitoneal injection cpg odn total weeks cpg irradiation plus cpg odn treatment irradiation total weeks control ctl cpg odn treatment study found cpg odn treatment attenuated lung fibrosis collagen deposition increasing number macrophagocytes levels type cytokines tgf cpg odn administration regulated expression tlr stat phosphorylation reversed expression type immune response key transcription factor gata activation jak stat signaling pathway enhanced macrophage differentiation type cytokine production study reveals mitigating effect early exposure cpg odn lung injury caused irradiation mice potential mechanism action may related enhancement type immunity conclusion cpg odn may potential therapeutic target treat rilf elsevier ltd rights reserved
explosion data grows rate roughly five trillion bits second giving rise greater urgency conceptualizing infosphere floridi understanding implications knowledge public policy philosophers technology information technologists alike wrestle ontological epistemological questions digital information tend emphasize floridi information new ecosystem human beings interconnected informational organisms inforgs home ambient intelligence linguistic conceptual representations big data massive volume structured unstructured data real world practice data mining patterns meaningful interpretation evidence reveal tension ambiguity bold promise data analytics paper explores tacit epistemology rhetoric representation big data suggests richer account ambiguities paradox real world materiality argue big data recognized manifesting multiple conflicting trajectories reflect human intentionality particular patterns power authority patterns require attentive exploration moral appraisal resist simplistic informationist ontologies big data subtle forms control political ecology big data undermine promise transformational knowledge
purpose new methods introduce topics classrooms needed enhance construction management educational experience one new methods showing real time videos highlight various elements concern classroom lecture purpose paper use augmented reality technology art layer artificial visualizations simulate environmental context spatio temporal constraints various construction processes superimposition images serves instructional mechanism virtually incorporate jobsite experiences classrooms enhancement spatio temporal constraints enables learners visualize context hidden processes otherwise unattainable traditional classroom lectures design methodology approach significantly improved perception reality created combination learners ability understand complexity construction products assemblies associated jobsite processes viewing real environment augmented computer generated information layers findings testing art video classroom undergraduate construction management students showed students exposed art video able remember identify highlighted elements corresponding assembly effectively originality value art valuable tool enhancing classroom learning gives educators teaching advantage combine traditional classroom lectures art enabled media
pulmonary fibrosis characterized destruction lung tissue architecture formation fibrous foci currently satisfactory treatment emodin component chinese herb reported medicament pancreatic fibrosis liver fibrosis however role pulmonary fibrosis established yet present study investigated hypothesis emodin plays inhibitory role tgf beta induced epithelial mesenchymal transition emt alveolar epithelial cell emodin exerts effect notch signaling pathway emodin inhibits proliferation rat alveolar type epithelial cells rle concentration dependent manner reduces expression collagen alpha sma vimentin promotes expression cadherin moreover emodin could regulate expression patterns notch signaling pathway related factors reduce notch nucleus translocation knockdown notch enhances inhibitory effect emodin tgf beta induced emt rle cells conclusion data present study suggests emodin suppresses top beta induced emt alveolar epithelial cells notch signaling pathway shows potential effective treatment pulmonary fibrosis elsevier inc rights reserved
nonlinear differential equation governing periodic motion one dimensional undamped unforced cubic quintic duffing oscillator solved exactly providing exact expressions period solution period given terms complete elliptic integral first kind solution involves jacobi elliptic functions particular cases obtained varying parameters characterize oscillator presented discussed behaviour period function initial amplitude analysed exact solutions velocities several values initial amplitude plotted fourier series expansions exact solutions also obtained allows conclude quintic term appearing cubic quintic duffing equation makes nonlinear oscillator complex also interesting study
contributors special issue use qualitative methodologies explore questions traditionally posed demographers introduction summarizes article surveys wider potential significance qualitative research historical demography authors suggest research disrupt traditional scholarly categories methods pertaining reproduction demographic phenomena qualitative sources may serve wild cards suggesting new paths investigation based individuals idiosyncratic viewpoints may also offer ways collapse integrate wide bodies knowledge contextualizing reframing blurred cross categorical world views associated individuals actionable ideas ideals studying views systematically become easier digitization human culture past present proceeds apace moreover digital tools accessing interpreting text become sophisticated individual aggregate level studies may increasingly understood single scholarly corpus rather two parallel approaches scattered mutual intelligibility intermittent cross fertilization explanations fertility decline continue center modernization often without speaking name authors suggest individual narratives offer way subjectivize modernization avoiding mystical incoherence extreme subjectivization
presence retinal vasculopathy absence typical predisposing factors suggest possible underlying hematologic abnormality cases systemic investigation may reveal potentially fatal hypercoagulability hyperviscosity syndrome retinal vein occlusion commonly encountered ophthalmic finding syndromes however abnormalities arterial system choroid macula also possible visual symptoms may manifestation underlying process making timely diagnosis ophthalmologist critical treatment thrombotic prophylaxis moreover newer ophthalmic diagnostic technologies arise increasingly important role eye physicians management syndromes elsevier inc rights reserved
carbon nanofibers cnf versatile nanomaterials widely used various fields science technology consequence animals well humans maybe exposed compounds via different routes hypothesized oral intake cnf lead inflammatory reaction consequently induce behavioral impairments address issue rats fed cnf days locomotor activity emotional status cognition quantified testing animals open field set elevated plus maze universal problem solving box provides information motivation cognition behavioral tests performed times within days end experiment blood samples collected plasma concentrations measured results demonstrated inflammatory reaction determined significantly elevated concentration however counteracted even pronounced increase behavioral effects restricted mainly decrease locomotor activity significant open field test well elevated plus maze parameters indicative cognitive performance influenced also emotional status largely unaffected conclusion results revealed oral intake cnf induced adverse effects however still partially compensated organism elsevier rights reserved
paper discusses development energy management supervisory control system ems hybrid electric vehicle hev built national instruments compactrio embedded controller labview real time software platform ems functions primary vehicle controller whose objective achieve optimal operation hybrid propulsion system reduced fuel consumption selfsustaining energy storage since vehicle non plug hybrid hev derives propulsion power two sources internal combustion engine ice electric motor ems receives inputs throttle position vehicle speed engine rpm battery state charge soc based certain control algorithm determines two sources operation status power distribution charging battery pack graphical driver interface implemented tablet tcp connection ems controller labview based interface appears dynamically controllable html page hosted web server function compactrio enabling driver monitor override control hybrid vehicle
paper presents results laboratory model tests surface strip footing unreinforced reinforced sand beds investigate effects reinforcement length multiples footing width employed tests namely tests even type number reinforcements also varied determine whether parameters influence optimum reinforcement length comprehensive results laboratory model tests strip footings supported woven geotextile different geogrids presented load settlement bearing ratio values obtained model test program compared based results length footing required achieve optimum improvement determined different numbers reinforcement layers different reinforcement types also observed improvement obtained reinforcing subgrade different low settlement ratio values large settlement values japanese geotechnical society production hosting elsevier rights reserved
solar enhanced natural draft dry cooling tower senddct efficient natural draft dry cooling tower utilizing solar radiation arid region three dimensional numerical model considering solar radiation effect developed investigate influence olsolar radiation intensity ambient pressure efficiency thermal characteristics senddct numerical simulation outcomes reveal model consideration radiation results less air mass indicates previous simulations overestimated solar energy obtained solar collector underestimated heat loss cooling performance improved higher solar radiation intensity ambient pressure air temperature velocity increase solar radiation intensity ambient pressure solar radiation intensity inverse effects changes air temperature velocity condition solar load increases ambient pressure decreases increased rate heat transferred heat exchanger obvious elsevier ltd rights reserved
sediment concentration fundamental determining sediment transport open channels rouse equation one several methods computing sediment concentration derived using deterministic hydraulic principles study derives rouse equation using shannon entropy theory derivation requires hypothesis cumulative probability distribution function sediment concentration terms flow depth formulated general form specialize several specific forms reported literature advantage using entropy theory permits quantification uncertainty associated concentration determination parameters terms specified information mean concentration elsevier rights reserved
considerable research effort devoted distinguishing changes caused environmental variability changes due structural damage unfortunately investigations studying operational variability traffic events lacking order obtain signals high quality need deal baseline drift problems mainly caused temperature changes traffic jams paper present new baseline correction method crossing method deal baseline strain signals collected sensor network installed concrete bridge piece wise method based probability theory method needs manual parameter selection used automatically real time baseline correction compare performance crossing method first derivative method iterative polynomial method experimental results indicate crossing method superior dealing civil engineering signals copyright john wiley sons ltd
objectives hypothesisthe study objective generate pilot data evaluate effectiveness safety esterase inhibitor concentrate inh compared standard treatment patients angiotensin converting enzyme inhibitor acei induced angioedema affecting upper aerodigestive tract study designproof concept case series historical control methodsadult patients angioedema upper aerodigestive tract presenting emergency department included establishing diagnosis acei induced angioedema based patient history thorough clinical examination patients administered international units inh intravenously historical control group consisting adult patients acei induced angioedema treated intravenous corticosteroids antihistamines institution past years used comparison important parameters assessed time complete resolution symptoms need intubation tracheotomy resultsten patients included inh group corticosteroid antihistamine group time complete resolution symptoms considerably longer historical control group hours inh group hours intubation tracheotomy needed inh group patients whereas three historical controls required tracheotomy two intubated conclusionthe results suggest role inh effective safe therapeutic option patients acei induced angioedema needs confirmed larger double blinded studies level evidence laryngoscope
european directive regarding promotion energy renewable sources directive specifies separate national targets member state community order least total energy demands met renewable energy sources analysis performed work highlights grid connected photovoltaic systems bring remarkable energy benefits electricity supply greece meeting parallel national targets validated data reported operator hellenic electricity market lagie hand mass energy production coming systems without energy storage units sufficient electricity network architectures liable cause severe disturbances greek electricity network issue acknowledged representative data hellenic electricity power transmission distribution network operators admie hedno furthermore sustainable innovative electricity network architectures micro grids smart grids web cells well innovative intermittent renewable energy sources res stabilization techniques discussed order facilitate high pvs integration level elsevier ltd rights reserved
paper application cots commercial shelf tegs thermoelectric generator bite type power supply autonomous sensors investigated architecture teg system established expected electrical power provision simulated tested agreement better one order magnitude simulation test mission heat flow teg may reverse therefore taken account design corresponding electrical circuits teg sensitivity low temperatures degrees found addressed via selection different cots teg types tested without problems degrees concept central provision electrical power tegs discussed shortly showed need new high temperature tegs operate temperatures degrees elsevier ltd rights reserved
strong interest radar absorbing materials rams took place years due extensive sectors application rams coatings whose electric magnetic properties allow absorption microwave energy certain frequencies particular rams effective means radar cross section rcs reduction context stealth technology rcs reduction requires absorbers broad band characteristics since surveillance radars often employ wide bandwidths carbon fiber reinforced plastic cfrp composites made short carbon fibers embedded polymer matrix allow broad band radar absorbing materials rams characterized low reflection coefficient impinging electromagnetic fields high resistance environmental hazards
calcitonin gene related peptide cgrp neuropeptide system important still evolving target migraine fundamental consideration current drugs clinical trials ongoing development area identity expression pattern function cgrp receptors knowledge informs safety efficacy considerations recent years calcitonin receptor like receptor receptor activity modifying protein ramp complex known cgrp receptor generally considered relevant however cgrp capable activating multiple receptors could one endogenous receptor recent identification cgrp responsive calcitonin receptor ramp complex amy receptor amylin subtype receptor trigeminovascular system warrants deeper consideration molecular identity cgrp receptor involved pathophysiology thus potential treatment migraine perspective considers issues implications
background aims poorly digested fermentable carbohydrates may induce symptoms irritable bowel syndrome ibs via unclear mechanisms performed randomized trial magnetic resonance imaging mri analysis investigate correlations symptoms changes small large bowel contents oral challenge methods performed period cross study adult patients ibs based rome iii criteria symptoms abdominal pain discomfort least days reported bloating parallel performed study healthy individuals controls studies performed united kingdom january february separate occasions least days apart subjects given drink containing carbohydrate glucose first period fructose second inulin third random order levels breath hydrogen measured intestinal content assessed mri various time points consumption drink symptoms determined based subjects responses hospital anxiety depression scale questionnaire patient health questionnaire primary end point whether participants clinically important symptom response minutes consumption drink results patients ibs reached predefined symptom threshold intake inulin fructose glucose symptoms peaked sooner intake fructose inulin fructose increased small bowel water content patients controls whereas inulin increased colonic volume gas fructose inulin increased breath hydrogen levels groups compared glucose fructose produced earlier increase inulin controls lower symptom scores period drink consumption patients ibs despite similar mri parameters breath hydrogen responses patients reached symptom threshold inulin intake peak symptom intensity correlated peak colonic gas changes mri features peak breath hydrogen levels similar patients reach symptom threshold conclusions patients ibs healthy individuals without ibs controls similar physiological responses intake fructose inulin patients reported symptoms frequently inulin controls patients response inulin symptoms related levels intraluminal gas peak gas levels differ significantly responders nonresponders controls indicates colonic hypersensitivity distension rather excessive gas production produces carbohydrate related symptoms patients ibs
even variation nusselt number reynolds number observed little studies concerning nanofluids present numerical data laminar regime also found correlate well brinkman number individual sets much better globally combining data sets nanofluids water thus work proposes new correlation heat transfer rate brinkman number nondimensional number viscosity flow velocity temperature results showed good empirical equation nul dependent power law function brinkman number laminar flow regime proposed correlation applied water nanofluid flow respect nanoparticle loading expected equation suggested work useful design heating cooling devices elsevier ltd rights reserved
digital filter symbolic analyzer dfsa new program built using combination visual basic languages based simple efficient algorithm known successive multiplier extraction calculate symbolic transfer function algorithm considered signal flow graph method uses fade approximation within calculation steps program designed operate microsoft windows elegant simple main feature dfsa enables user enter network drawing using special easy use tools help draw desired network
mixed analog digital cmos chip intended read silicon strip detectors future linear collider experiments developed currently testing chip optimized silicon micro strip tracking device includes channels full analog signal processing chain corresponding digital control readout every analog channel includes low noise charge amplifier integration long pulse shaping eight eight positions analog sampler storing successive events reconstructing full pulse shape iii sparsifier performing analog sum three adjacent inputs decide whether signal whole system controlled digital part allows configuring reference currents voltages drives control signals analog memories records timing channel information subsequently performs conversion digital values samples total surface circuit analog channel occupying area remaining space filled analog channels silicon elsevier rights reserved
recent years increasing number researchers become involved wireless sensor networks wsns cloud computing however integrating wsn cloud computing technology monitor environment still open issue paper propose wsn mobile device based environmental monitor based saas software service cloud computing architecture first scheme provide spare two tier data aggregation wsns automatically report event data flood fire events cloud servers also use simulation tool implement prove automatic report model outperform schemes second model mobile device based event reporting scheme environmental monitoring system since events structural damage dams bridges reported automatically propose using mobile device report events proposed second scheme defend denial service dos man middle attacks achieve mutual authentication ensure data security address network security issues
increased incidence neuronal nuclear indentations well known feature striatum huntington disease brains alzheimer disease neuronal nuclear indentations recently reported correlate neurotoxicity caused improper cytoskeletal nucleoskeletal coupling initial detection rod shaped tau immunostaining nuclei cortical striatal neurons brains hippocampal neurons early braak stage led coin term tau nuclear rods tnrs although tnrs traverse nuclear space fact occupy narrow cytoplasmic extensions fill indentations nuclear envelope refer histological hallmark tau immunopositive nuclear indentations tnis reasoned tni formation likely secondary tau alterations tni detection correlates increase total tau particularly isoforms four tubulin binding repeats tau analyze transgenic mice overexpress human tau frontotemporal lobar degeneration tau point mutation mice explore whether tau alteration sufficient tni formation immunohistochemistry various tau antibodies immunoelectron microscopy double tau immunofluorescence dapi nuclear counterstaining confirmed excess tau mice sufficient detection abundant tnis fill nuclear indentations interestingly correlate increase number nuclear indentations thus suggesting excess total tau isoform imbalance favor tau facilitates tau detection inside preexisting nuclear indentations induce formation latter summary demonstrate tau alteration sufficient tni detection results suggest neuropathological finding tnis becomes possible indicator increased total tau increased tau ratio affected neurons apart efficient way monitor pathology associated nuclear indentations
aim literature review examine evidence psychotherapeutic pharmacological treatments subjects severely dysregulated mood identify potential areas improvements research designs literature search conducted using several databases published pubmed psycinfo ongoing clinical trial registries studies conducted youths met nimh criteria severe mood dysregulation smd dsm diagnosis disruptive mood dysregulation disorder dmdd eight completed studies identified three randomized trials four open pilot studies one case report seven ongoing studies found trial registries available evidence suggests potential efficacy psychotherapies previously developed internalizing externalizing disorders two main pharmacological strategies tested first monotherapy psychostimulant atypical antipsychotic risperidone already used treatment severe irritability youths developmental disorders second use serotonergic antidepressant add therapy youths treated psychostimulant ongoing studies clarify effectiveness psychotherapeutic interventions dmdd individuals whether given alone conjunction treatments short duration trials chronic disorder low number studies lack placebo active comparator arm restrictive inclusion criteria controlled trials dramatically limit interpretation results finally future research conducted across multiple sites standardized procedures measure dmdd symptoms reduction include run period limit placebo effect
mechanical properties needled nonwoven geotextile materials depend structural solutions well technological conditions production thereby structural physical mechanical properties fibers surface mass geotextiles needling process parameters important function paper presents results analysis mechanical characteristics nonwoven geotextile material made virgin pes fibers recycled pes fibers surface masses also elastic limits deformation needled geotextile materials determined define permitted loads geotextile materials subjected without disturbing structure force intensities work forces determined elastic limits geotextiles relationship appropriate breaking parameters presented proposed method results used predict permitted loads non woven geotextile material may subjected exploitation
water pollution well known major problem tai lake basin china compared industries domestic sewage non point pollution agriculture difficult detect measure control therefore range policies formulated among adjustment planting structure however policy implementation used simply convert paddy fields dry land food crops cash crops surprisingly date research provided evidence agricultural land use change contributes reduction agricultural nutrient pollution based extensive farm survey research finds conversion rice paddy dry land farming generated positive effect nutrient pollution control estimated nitrogen runoff agricultural land increased phosphorus runoff increased two times since land use patterns changed farmers inclined apply fertilizer dry land paddy fields however agricultural land use change economically effective land use conversion increases net profits farming significant way demonstrated compared environmental concerns economic considerations seen greater benefits adjustment planting structure findings important implications policy making local authorities efforts improve environmental management pollution control territories
background pluripotent small embryonic like stem cells vsels induced pluripotent stem ips cells reported nobel prize awarded ips technology whereas even today existence vsels well accepted underlying reason vsels exist low numbers remain dormant homeostatic conditions small size pellet vsels maintain life long tissue homeostasis serve backup pool adult stem cells mobilized stress conditions imbalance vsels function uncontrolled proliferation may result cancer search methods electronic database medline pubmed systematically searched subject heading term small embryonic like stem cells objective rationale primitive stem cells undergo asymmetric cell divisions self renew give rise progenitors still remain elusive hematopoietic system testes presence stem cells ovary still debated propose review available literature vsels methods isolation characterization ontogeny compare embryonic stem cells primordial germ cells pgcs ips cells role maintaining tissue homeostasis review includes look ahead vsels result paradigm shifts basic reproductive biology outcomes adult tissue specific stem cells including hematopoietic spermatogonial ovarian mesenchymal stem cells good proliferation potential indeed committed progenitors cytoplasmic oct arise asymmetric cell divisions pluripotent vsels nuclear oct vsels primitive stem cells postulated overlapping population pgcs rather migrating gonads pgcs migrate survive various adult body organs throughout life vsels vsels express pluripotent pgc specific markers epigenetically developmentally mature compared cells obtained inner cell mass blastocyst stage embryo result vsels readily differentiate three embryonic germ layers spontaneously give rise sperm oocytes vitro like pgcs vsels divide readily culture produce teratoma integrate developing embryo property relatively quiescent allows endogenous vsels survive various kinds toxic insults vsels survive oncotherapy targeted induce endogenous regeneration non functional gonads transplanting healthy niche mesenchymal cells resulted improved gonadal function live births wider implications quiescent vsels possibly accumulate genomic nuclear mitochondrial mutations thus may ideal endogenous pluripotent stem cell candidates regenerative reproductive medicine presence vsels adult gonads fact survive oncotherapy may obviate need bank gonadal tissue fertility preservation prior oncotherapy vsels ability undergo spermatogenesis neo oogenesis presence healthy niche help identify newer strategies toward fertility restoration cancer survivors delaying menopause also enabling aged mothers better quality eggs
engineering design follows six step sequence demonstration sequence materials engineering less common case study presented using paper gafner development gold titanium alloy paper identifies need develops problem identifies alternatives demonstrates use metallurgical principles identify alternative responses shows favorable options selected paper also used illustrate engineering design iterative process paper also useful starting point depth examination specific elements design process lends creation student exercises
backgroundthe angioedema quality life questionnaire qol recently developed validated first specific patient reported outcome tool assess quality life qol impairment recurrent angioedema patients yet sensitivity change minimal clinically important difference mcid established methodsrecurrent angioedema patients chronic spontaneous urticaria hereditary angioedema repeatedly asked complete qol along anchors qol impairment disease activity routine care visits sensitivity change qol determined correlating changes scores time changes applied anchors addition mcid determined using anchor based distributional criterion based approaches resultstwo hundred seventy eight patients contributed data sets analysis baseline qol values found correlate well results well applied anchors angioedema related qol impairment disease activity addition qol score changes time correlated significantly changes anchors thus demonstrating sensitivity change mcid qol total score found six points conclusionthe qol valuable tool assess changes qol impairment recurrent angioedema patients time including changes due treatment
background aims previous studies shown antidepressants reduce inflammation animal models colitis present trial aimed examine whether fluoxetine added standard therapy crohn disease maintained remission improved quality life qol mental health people compared placebo methods parallel randomized double blind placebo controlled trial conducted participants clinically established quiescent mild disease randomly assigned receive either fluoxetine daily placebo followed months participants provided blood stool samples completed mental health qol questionnaires immune functions assessed stimulated cytokine secretion stimulation flow cytometry cell type linear mixed effects models used compare groups results participants randomized receive fluoxetine placebo overall participants male mean age years fluoxetine effect inflammatory bowel disease activity measured using either crohn disease activity index faecal calprotectin modest effects immune function effect fluoxetine physical psychological social environmental qol anxiety depressive symptoms compared placebo conclusions small pilot clinical trial fluoxetine superior placebo maintaining remission improving qol
children adolescents multicultural families immigrant mother tend experience stress due problems cross cultural adaptation south korea homogeneous cultural identity study explored impact acculturative stress externalizing behavior problems aggressiveness delinquency among elementary middle high school students gyeonggi analyzed mediating effects acculturative stress externalizing behaviors using structural equation modeling bootstrapping method results showed stress experienced relation cultural adaptation indirectly affected externalizing behaviors school maladaptation indicates acculturative stress directly affect externalizing behaviors children adolescents immigrant mothers appear increase difficulty adjusting school environment maladaptation worsens externalizing behaviors may subsequently develop schools must function protective environment externalizing behavior problems associated acculturative stress
compressive receiver presented utilizing composite right left handed crlh dispersive delay line ddl analog signal processing applications crlh ddl offers advantages arbitrary frequency operation wide bandwidth filling gap competing ddl technologies presented system utilizes impulse driven crlh ddl mixer inversion chirp generation required real time signal processing high frequencies eliminates frequency ramp generators employed frequency discriminator tunable delay line dispersion compensation simulation experimental results fully validate presented systems proof concept high frequency applications real time fourier transformers signal analyzers
introduction according primary infertility india age standardized year age standardized year using age birth definition several factors affect fertility include low sperm production men poor egg quality blocked fallopian tubes women also hormonal imbalances leptin plays critical role women reproduction neuroendocrine health used treating exercise induced bone loss eating disorders infertility aim evaluate serum leptin levels indians ascertain relationship serum leptin levels unexplained infertility related variables height weight waist hip ratio whr body mass index bmi obese infertile non obese infertile healthy subjects materials methods present case control study conducted department obstetrics gynaecology king george medical university kgmu lucknow india funded department science technology new delhi india study included female participants age group years cases controls randomly selected blood samples collected infertility clinic queen mary hospital kgmu lucknow india participants underwent complete physical examination initially participants categorized fertile infertile groups divided basis bmi normal bmi overweight obese bmi leptin level measured active human leptin elisa kit bmi subjects calculated weight height results highly positive linear correlation found bmi serum leptin unexplained infertile women indicates strong relationship bmi serum leptin variation serum leptin explained independent variable bmi partial positive linear correlation bmi serum leptin control group statistically significant correlation bmi serum leptin control group conclusion present study clearly demonstrates level leptin higher unexplained infertile fertile group also shows strong relationship exists bmi serum leptin obese group serum leptin level significantly higher obese non obese subjects thus leptin important factor normal reproductive function obesity main cause infertility may controlled regulating leptin concentration
understanding metal oxidation critical corrosion control catalysis synthesis advanced materials engineering although metal oxidation process rather complicated different processes many coupled involved onset reaction since first introduced great success applying heteroepitaxial theory oxide growth metal surface demonstrated oxidation experiments paper review recent progress experimental findings oxidation well advances theoretical simulations oxidation process focus effects defects step edges present realistic metal surfaces oxide growth dynamics show surface steps change mass transport atoms oxide growth ultimately lead formation different oxide morphology also review oxidation alloys explore effect secondary element oxide growth surface review work oxidation demonstrate correlation theoretical simulations multiple scales various experimental techniques elsevier rights reserved
disorders operation machines caused whole group internal external influences processes act way directly machines influences effect changing properties machine parts summary processes called mechanism failures mechanism failures effect properties machine parts changed new technologies include use biofuels widely used substitute fossil fuels covers majority energy consumption transport sector particularly automotive industry currently enforced ethanol biofuel european union heading efforts promote use biofuels biofuels substitute fossil fuels partially produced blending fossil fuels biofuels effect using studied type passenger car saab engine car taken sampled engine oil operation operation fossil fuel internal combustion engine analyzed vehicle uses motor oil type mobil analyzes samples confirmed great influence viscosity motor oil therefore also deterioration lubricity increased engine wear measurements performed laboratory quality reliability machines culs first half
midkine gene name mdk heparin binding growth factor regulates cell growth cell survival migration anti apoptotic activity nephrogenesis development kidney expressed mainly proximal tubular epithelial cells induced oxidative stress activation hypoxia inducible factor alpha pathophysiological roles diverse ranging occurrence acute kidney injury aki progression chronic kidney disease often accompanied hypertension renal ischemia diabetic nephropathy particular hypertension indispensable implications various vascular diseases including cardiovascular renal disorders mdk mice exhibited marked hypertension renal ablation model compared mdk mice eventually leading progressive renal failure glomerular sclerosis tubulointerstitial injuries association elevated plasma angiotensin ang levels also induced lung endothelium oxidative stress subsequently regulated angiotensin converting enzyme ace lung ang hydrolyzed ace induce oxidative stress accelerating generation leading vicious cycle positive feedback ang pathway kidney lung interaction involving positive feedback renin angiotensin system may part account pathogenesis hypertension kidney injury addition pathway involved pathogenesis diabetic nephropathy aki recruitment inflammatory cells multidisciplinary findings may open new avenues targeting therapies hypertension various renal diseases including aki diabetic nephropathy
nickel ions key element metabolism numerous lower organisms required activity nine enzymes nife hydrogenase catalyzes reversible oxidation molecular hydrogen energy production nickel homeostasis nickel transport cell strictly controlled hupe transmembrane nickel transporter rhizobium leguminosarum hydrogenase system conserved periplasmic terminal domain responsible nickel binding work focuses interactions region native two metal ions might interfere nickel binding hupe fragment metal coordination sites assigned thermodynamic parameters discussed detail order evaluate potential effectiveness different soil concentrations displace binding site physiological coordination sphere three metal complexes consists imidazole amine nitrogens histamine like binding imidazole able displace binding site neither equimolar concentrations soil metal concentrations rhizobium leguminosarum numbers expected decrease several orders magnitude elsevier rights reserved
moving towards sustainable society hydrogen fueled polymer electrolyte membrane pem fuel cell technology seen great opportunity reduce environmental impact transport sector however decision makers challenge understanding real environmental consequences producing fuel cell vehicles fcvs compared alternative green cars battery electric vehicles bevs conventional internal combustion engine vehicles icev work presented comprehensive life cycle assessment lca fcv focused manufacturing phase compared production bev icev manufacturing phase fcv inventories started catalyst layer glider including hydrogen tank sensitivity analysis key components fuel cell stack system balance plant hydrogen tank carried account different assumptions materials inventory models production process fuel cell vehicle showed higher environmental impact compared production two vehicles power sources mainly due hydrogen tank fuel cell stack however combining results sensitivity analysis component best case scenario showed potential reduction climate change impact category fcv compared baseline fcv scenario reducing environmental impact associated manufacture fuel cell vehicles represents important challenge entire life cycle also considered manufacturing use disposal fcv electric vehicle conventional diesel vehicle compared overall icev showed highest gwp mainly due use phase fossil carbon emissions associated use diesel elsevier ltd rights reserved
background limited data regarding associated factors return sports activities years anterior cruciate ligament acl reconstruction purpose test interrelationships patient characteristics concomitant articular lesions graft laxity maintenance sports activities years acl reconstruction hypothesized years operation young adult men maintenance greater activity level better knee function would associated greater preinjury activity level younger age reconstruction absence concomitant articular lesions minimal graft laxity follow study design case series level evidence methods one hundred six men autologous hamstring acl reconstruction ages years reviewed years surgery excluded patients contralateral acl tear revision reconstruction another injury impairing function fifty five patients eligible available follow independent variables included preinjury tegner score time interval injury surgery smoking status age articular lesions side side difference pivot shift grade main outcome measures tegner activity level international knee documentation committee ikdc subjective score knee injury osteoarthritis outcome scale koos score years surgery results greater tegner activity level follow associated regression model greater preinjury tegner activity level correlation coefficient lower difference correlation coefficient negative pivot shift correlation coefficient younger age operation predicted return greater tegner activity level univariate analysis correlation coefficient regression model significant chondral lesions surgery predicted lower ikdc subjective scores koos scores affect maintenance sports activities conclusion years autologous hamstring acl reconstruction young men predictors greater sports activity level primarily high preinjury activity level reestablishment knee laxity younger age operation moderate chondral lesions lower impact respect
background next generation sequencing ngs technologies provide exciting possibilities whole genome sequencing plethora organisms including bacterial strains phages many possible applications research diagnostics streptomyces flavovirens phages sequenced date therefore lack available information flavovirens phage genomics report biological physiochemical features use ngs provide complete annotated genomes two new strains virulent phage streptomyces flavovirens isolated egyptian soil samples results flavovirens phages examined study show higher adsorption rates respectively actinophages indicating strong specificity host latent periods min followed rise periods min expected actinophages burst sizes virions per phages stable reported previous experiments showed significant increase activity sodium chloride nacl magnesium chloride mgcl treatments whereas zinc chloride zncl application phages showed significant decrease infection sequenced phage genomes parts singleton cluster sizes respectively bioinformatics analyses functional characterizations enabled assignment possible functions putative identified orfs included phage structural proteins lysis components metabolic proteins thirty phams identified phages known function used cluster prediction comparative genomic analysis revealed significant homology two phages showing highest hits among closest streptomyces phage vwb phages specific region however phylogenetic analysis using major capsid protein mcp sequences highlighted isolated phages belong streptomyces phage group clearly separated representing novel sub cluster conclusion results study provide first physiological genomic information flavovirens phages useful pharmaceutical industries based flavovirens future phage evolution studies
paper numerical experimental studies performed explain effect hydrogen enrichment lpg fuelled engine consequently effect cylinder flow characteristics engine performances exhaust emissions also influence intake system geometry cylinder mixture flow behavior studied cylinder flow velocity turbulence characteristics hydrogen mass fraction evaluated intake stroke order analyze intake flow behavior purpose computational fluid dynamics cfd code adopted variation brake torque brake specific fuel consumption bsfc nox emissions various engine speeds investigated gasoline lpg lpg hydrogen fuelled engines using experimental study engine performances investigated various fractions lpg hydrogen blends results shown produced lpg hydrogen blend increased compared gasoline pure lpg operations respectively hydrogen fraction equal particularly high engine speeds emissions tend eliminated addition hydrogen nox emissions lpg hydrogen operation decreased compared gasoline lpg fuels respectively simulation experiments results demonstrate benefits hydrogen enrichment cylinder flow characteristics engine performances elsevier ltd rights reserved
mobile devices including popular smartphone contributes efficiency improvement site data processing mobile environment real time data processing needs additional aspects besides desktop ones style mobile app mobile web mobile web app generally mobile app provides internal storage service offline data processing possible mobile app needs separate development according different types devices operating systems even different sizes display panel mobile devices geo based data composed vector raster formats complex structure compared data sets including image data multimedia data hence even though mobile applications development geo based data complicated ones users demands respect geo based data processing functionalities mobile environment increasing days mobile web supported technical basis hypertext markup language html regarded useful service type combining geo based data processing modules mobile environments require user downloading installation programs needs web browsers indexed application programming interface api within international web standard provides offline data storage functions mobile environment using api data sets permanently stored mobile devices cache memory among numerous geo data functionalities visualization topic basically commonly used mobile services study presents implementation case mobile web app geobased data visualization processing online offline mode types geo based data sets base map open street map osm osm vector layers extensible markup language xml contents high resolution satellite images optical sensor thought result implementation play role create intelligent mobile application fields using geo based data sets earth observation satellite image sets
background obesity continues increase united states elsewhere number published dermatologic associations purpose study characterize obesity among office visits dermatologic diseases methods data national ambulatory medical care survey namcs national hospital ambulatory medical care survey nhamcs searched common dermatologic diagnoses body mass index bmi could classified results dermatologic patient visits underweight normal weight overweight obese increasing age predicted yearly increased likelihood obesity logistic regression controlling age sex race dataset found addition age nhamcs dermatologic diagnosis patients likely obese namcs patients specific diseases found highest obesity rates including psoriasis hidradenitis suppurativa acanthosis nigricans conclusion large proportion dermatologic diagnosis patients obese awareness could lead interventions may improve disease decrease risks comorbidities
efficiency wind power conversions systems greatly improved using appropriate control algorithm paper deals cerebellar model articulation controller coupling proportional integral derivative controller direct drive permanent magnet synchronous wind turbine generator first aerodynamic characteristics wind turbine studied detail moreover transfer function pitch angle speed wind turbine established finally tests proposed method carried including random wind speed using numerical simulation tests several operating conditions simulated satisfactory results obtained
multi sensor data fusion based multiple features high dimensionality feature space increases runtime computational complexity present study proposes new algorithm based combination random subspace linear discriminant analysis sparse regularisation ldasr namely ldasr feature space dimensionality reduction supervised feature selection learning use rss effectively solve problem high dimensionality high feature instance ratio extraction multiple features images raises possibility correlation features reduce classification accuracy study construction several rss supervised feature selection learning based ldasr applied high accuracy classification image fusion remote sensing data analysis tested implementation feature based fusion two pairs fused synthetic aperture radar optical data four feature matrices constructed using attribute profiles aps multi aps maps non negative matrix factorisation nmf textural features support vector machine rotation forest applied base classifiers results show use ldasr significantly improved classification accuracy based nmf plus texture features even nmf alone
animal behavior research main task observing behavior animal usually done manually measurement trajectory animal real time posture description often omitted due lack automatic computer vision tools even though many publications pose estimation efficient enough apply real time used without machine learning algorithm train classifier mass samples paper propose novel strategy real time lobster posture estimation overcome difficulties proposed algorithm use gaussian mixture model gmm lobster segmentation posture estimation based distance transform skeleton calculated segmentation tested algorithm serials lobster videos different size lighting conditions results show proposed algorithm efficient robust various conditions
cell culture preclinical animal models traditionally implemented investigating underlying cellular mechanisms human disease progression however increasing significance cell culture initiated new era cell culture research vitro models emerging bridge traditional cell culture vivo animal models additive manufacturing also known printing defined layer layer fabrication parts directed digital information computer aided design file offers advantages simultaneous rapid prototyping biofunctionalization well precise placement cells extracellular matrix high resolution review highlight recent advances printing tissue engineered constructs recapitulate physical cellular properties tissue microenvironment investigating mechanisms disease progression screening drugs
objectivesthe goal study investigate role sex age negative chronotropic effect exposure mhz pulsed ultrasound rat heart methodsforty rats exposed transthoracically ultrasonic pulses duty factor approximately mpa peak rarefactional pressure amplitude transthoracic ultrasonic bursts delivered consecutively five intervals pulse repetition frequency prf prf prf prf total exposure duration rats divided groups young male control young male young female control young female old male control old male old female control old female resultstwo way anova repeated measures used compare heart rate cardiac output arterial pressure hemodynamic values baseline stimulation sex versus age versus interaction detected heart rate cardiac output showed age effect ejection fraction showed age effects arterial pressure showed sex effect negative chronotropic effect approximate decrease heart rate observed young female rats hypothesis effect weight menopause dependent young premenopausal female rats weighed approximately less groups rats conclusionsit likely ovarian hormones responsible different induced cardiac bioeffects different ages sexes
increasing trend use aluminium alloys vehicle components makes necessary summarize state art related approval structural durability operational conditions paper procedures experimental numerical service strength evaluations cast forged welded aluminium alloy components presented also present results investigations influence corrosion well methods accelerated test approval validated practical approach recommended journal mechanical engineering rights reserved
specific pathognomonic tissue changes establish death water intoxication makes postmortem diagnosis water intoxication difficult report autopsy case fatal water intoxication postmortem computed tomography pmct examination showed findings suggestive antemortem excessive water drinking diluted intestinal contents hemodilution year old man schizophrenia found dead house frequently complained polydipsia drank large amount water vomited death pmct findings showed distention duodenum low radiodensity content addition right atrium showed low radiodensity content autopsy results showed moderate congestion organs large amount light brownish liquid duodenum upper jejunum aspiration pneumonia electrolyte concentrations sodium vitreous humor right left eyes meq respectively neither drugs alcohol detected blood basis autopsy biochemical findings determined water intoxication cause death evaluation pmct findings cases various causes death indicated radiodensities right atrium duodenal content case lower cases various causes death except fresh water drowning present case showed pmct provides supplementary findings regarding antemortem excessive water drinking addition pmct may provide findings consider death water intoxication autopsy
objectivedyspepsia common condition huge impact quality life working capacity causes well understood association stress dyspepsia debated decades issue resolved examined year risk redeeming proton pump inhibitor receptor antagonist proxy dyspepsia according level perceived stress participants methodsperceived stress measured general health survey danes aged older years age using cohen perceived stress scale data linked individually national registries including danish national prescription registry risk redeeming proton pump inhibitor receptor antagonist quintiles stress level estimated using cox proportional hazard regression resultsin total redeemed one drugs months follow cumulative incidence proportion dyspepsia increased gradually quintiles stress full model adjustment four highest stress quintiles statistically significantly increased risk redeeming drug compared lowest stress quintile hazard ratios confidence interval second quintile third quintile fourth quintile fifth quintile conclusionhigher levels self reported perceived everyday life stress increased risk redeeming drug dyspepsia significantly months follow copyright author published wolters kluwer health inc
pilot mindfulness home intervention conducted weeks among year old children born esophageal atresia parents participants randomly assigned waiting list control wlc group experimental group participants completed mindfulness based program data pooled treated entire sample self assessment measures included mindful attention awareness scale adolescents maas child adolescent mindfulness measure camm modified spielberger state trait anxiety inventory child stai children depression inventory cdi cognitive emotion regulation questionnaire kids version cerq parental assessment measures included modified stai results underlined program feasibility acceptability clinical effects mindfulness based program observed self assessed data children practiced mindfulness compared wlc group showed increased mindfulness decreased depression reduced anxiety found groups positive affect tended improve pre test post test children practiced mindfulness compared wlc group parental assessments showed significant improvement positive affect decreases anxiety negative affect intervention group compared wlc group cognitive emotion regulation strategies also affected mindfulness based program rumination scores significantly decreased pre test post test intervention group preliminary study suggests regular mindfulness practice presents promising approach reducing burden neonatal malformation
research violence television directed main efforts mostly quantitative statistical analysis media violence well detailed experimental studies effects specific scenes violence present work deals interpretation spectators media violence based analysis focus groups tries shed light mediating factors dimensions broadcasted violence possible effects particular conditions recognition classification violence scenes functions violent images emotions feelings aroused well processes identification main characters analysed
user interface design patterns mobile applications provide solution design problems improve usage experience users however lack research categorizing uses design patterns according users hand dominance learning based mobile classified main design patterns mobile applications investigated relationships major learning tasks students use different patterns compared respect hand dominance questionnaire patterns administered participants number patterns used analyzed design patterns mobile learning significantly differed left right hand dominant participants also performed cluster analysis explore possible theme sets among participants regard hand dominance learning results revealed three cluster solutions left right hand dominant groups profiled solutions based insights obtained structured interviews findings provide evidence pattern use differs right left hand dominant users regard reading information retrieval information browsing tasks findings facilitate development suitable uis educational mobile applications
channel width length ratio important transistor parameter integrated circuit design contact diffusion channel fabrication operation alters channel width important parameter novel methodology combining atomic force microscopy scanning kelvin probe microscopy skpm self consistent modeling developed nondestructive detection contact diffusion active devices scans surface potential modeled using physically based technology computer aided design tcad simulations transistor terminals grounded biased conditions simulations also incorporate tip geometry investigate effect measurements due electrostatic tip sample interactions method particularly useful semiconductor metal semiconductor interfaces potential contrast resulting dopant diffusion usually detectable scanning probe microscopy
present important theoretical experimental results obtained field fracture mechanics materials durability structural elements main foundations concepts fracture mechanics strength cracked elastoplastic bodies formulated urgent problems advanced studies field science materials strength posed problems fatigue fracture durability metals operating working media also investigated
speed limits common traffic regulation balancing traffic mobility safety roadways speed transition zones bear complicated driver behaviours however driver behaviours even complex speed transition zones dynamically created shifted variable speed limits vsls much existing research estimated long term driver compliance evaluated effectiveness speed enforcement attempted involve compliance vsl control algorithms whereas limited research provides convincing solutions representing speed limit effect estimating real time driver compliance speed transition zones fill research gap paper analyses field data two speed transition zones along southbound street edmonton canada temporal spatial variations speed driver compliance investigated detail using statistical tests linear regression established rank contributions selected factors finally suggestions guidelines vsl algorithm design implementation proposed
appraisal interviews ais one commonly used human resource practices organizations however often criticized comprising conflicting purposes study focus contextual factors appraisal process specifically propose ais follow two phase model performance evaluation development planning two phases trigger different levels employee appraisal participation turn affects employees perception voice sample audiotaped ais coded employees objective appraisal participation throughout entire interview session linked subsequent ratings perceived voice results showed interviews highly leader centered mainly concentrated performance evaluation employees appraisal participation significantly lower performance evaluation development planning appraisal participation development planning performance evaluation related subsequent ratings perceived voice addition relationship moderated supervisor trust
paper high gain low noise amp designed designing high gain amp large values coupling capacitor gain decrease since requirement increase gain designed three stage amp designed circuit provides gain much larger two stage amp trade various parameters like phase margin gain slew rate etc example achieve larger values gbw decrease compared results two values input common mode range improvement designed circuit done achieve desired gbw recalculating transistor ratios simulating results gain bandwidth product mhz phase margin greater degrees achieved cost power dissipation area amp designed gpdk cmos technology
identification nonlinear structural system important challenging task structural health monitoring due complexities structural nonlinearities hard establish proper mathematical models structural nonlinear behaviors moreover partial structural responses measured practice essential conduct identification nonlinear structural systems using partial measurements structural responses cope issues algorithm proposed article identification model free structural nonlinear restoring forces using partial measurements structural responses first equivalent linear structural system introduced identification locations structural nonlinearities model free structural nonlinear restoring force approximated power series polynomial unknown coefficients power series polynomials together structural parameters identified extended kalman filter characteristics behaviors model free nonlinear restoring forces identified numerical examples including identification two nonlinear multi story shear frames planar nonlinear truss different structural nonlinear restoring forces used validate proposed algorithm
objective unusual clinical course background acute coronary syndrome acs present atypical chest pain symptoms attributed heart disease indigestion hiccups benign self limited condition become persistent intractable overlooked underlying etiology various causes protracted hiccups including metabolic abnormalities psychogenic disorders malignancy central nervous system pathology medications pulmonary disorders gastrointestinal etiologies rarely attributed cardiac disease case report report case intractable hiccups year old male cocaine related myocardial infarction stent placement coronary angiogram showed stent thrombosis initial intervention following thrombectomy balloon angioplasty stent patient recovered well without additional episodes hiccups although hiccups known present predilection particular cause myocardial ischemia case may additionally explained sympathomimetic effects cocaine lead vasoconstriction coronary arteries conclusions hiccups associated cardiac enzyme elevation ekg segment elevation percutaneous coronary intervention pci maybe manifestation acute without stent fact patient cocaine user may contributed unique presentation
study examined risk deterioration relapse pregnant women discontinued antidepressant medications based discretion psychiatric specialists compared performed self interruption reviewed obstetric records singleton deliveries beyond weeks gestation japanese red cross katsushika maternity hospital january december compared women continuing antidepressant medications throughout pregnancy incidence deterioration relapse higher women discontinued antidepressant medications regardless made decision interruption based discretion psychiatric specialists odds ratio confidence interval self interruption odds ratio confidence interval versus continuation medications careful observation required pregnant women complicated depressive disorders
based quantitative analysis nationally representative sample self reported eligible blood donors united states paper investigates religion influences giving gift life find significant positive effects organizational subjective dimensions religion reasons dimensions promote generous act vary however religious service attendance works entirely religious ties ties turn influence various established channels donation including solicitation donate direct effect giving also indirect effects moral norms willingness donate addition impact ties religious group involvement encourages blood donation exposure messages helping others finally impact religious salience operates belief better give receive well religious ties implications findings literature blood donation larger scholarship religion generosity discussed
objective investigate outcome stress urinary incontinence sui overactive bladder oab symptoms women urodynamic stress incontinence usi transobturator sling procedures tots evaluated consecutive patients usi undergone tot tertiary hospital patients received evaluations including structured urogynecological questionnaires pelvic organ prolapse quantification examination months surgery one hour pad test urodynamic testing performed months postoperatively patient demographics lower urinary tract symptoms urodynamic results analyzed pure usi usi oab symptoms persistent sui occurred patients months patients months postoperatively common oab symptom frequency followed urgency urinary incontinence urinary urgency nocturia oab symptoms resolved month month follow ups patients treated tot treated tot combined pelvic surgeries significant difference preoperative urodynamic changes patients pure usi usi without oab groups however postoperative urodynamic results showed significant decrease maximal urethral closure pressure group patients usi oab symptoms significant urodynamic changes group pure usi coexistent oab symptoms common women diagnosed usi symptoms may resolve months tot
introduction eating one fundamental sources happiness slimming diets would deprive enjoyment without granting something else instead example proper eating behaviours life permanent solution overweight related problems aim paper aims investigate psycho dynamic relationships might reason failure diets slimming diets method analysing overweight obesity failure slimming diets help cognitive behavioral therapeutic approach results applying principles confirmed laid cognitive behavioral therapy identify specific ethological causes present dieting gaining weight behaviours successfully used curative symptom problem oriented psychotherapy conclusion summary stated advised approach defined objective slowly small steps help learning methods continual transformation environment obese individuals shred unwanted behavioral attitudes build new attitudes transform new desirable habits also personalities chiselled
hla locus major histocompatibility complex situated chromosome hla shown associated susceptibility alzheimer disease study firstly investigated association gene variants hla brain structures mri large sample alzheimer disease neuroimaging initiative adni explore effects hla pathogenesis selected hippocampus parahippocampus posterior cingulate precuneus middle temporal entorhinal cortex amygdala regions interest rois hybrid population analysis results showed marginally significant association atrophy left parahippocampus atrophy left parahippocampus exists caucasians hla hla alleles atrophy right amygdala baseline particular haplotype tgacaagg surrogate marker hla founded positively associated atrophy right hippocampus baseline furthermore detected four associations mild cognitive impairment mci subpopulation analysis study provided preliminary evidences supporting hla caucasians contribute risk modulating alteration hippocampal volume hla gene variants appear play role altering related brain structures mri
objectives provide overview vestibular migraines presentation pathology diagnosis well update current diagnostic criteria methods review recent literature vestibular migraines performed results vestibular migraine process significant impact quality life afflicted disease attacks spontaneous positional vertigo migraine symptoms lasting several minutes inner ear disease exist migraine vestibular symptoms occurring vestibular migraine mimic inner ear disorders providing challenge clinicians establishing diagnosis recent diagnostic criteria vestibular migraine proposed joint committee barany society international headache society provide important standard clinical diagnosis research endeavor conclusion vestibular migraine challenging disease process diagnose treat proper diagnosis treatment requires thorough understanding current literature elsevier rights reserved
background studies amnestic mild cognitive impairment amci late life depression lld examined similarities differences syndromes investigated cognitive profile comorbid amci subclinical depressive symptoms amci may compare amci lld memory biases certain types emotional information may distinguish groups methods total amci amci lld elderly controls cont rated valence positive negative neutral pictures international affective picture system mean percent positive negative neutral images recalled compared within groups immediately minutes later results overall memory performance comparable amci amci recalled fewer items cont lld group differences emerged valence ratings considered immediate delayed recall positive negative pictures generally better remembered neutral pictures cont amci lld valence associated recall amci follow analyses suggested perceived intensity stimuli may explain emotional enhancement effect cont amci lld conclusions results support previous research suggesting neuropsychological profile amci different amci lld although depressed non depressed individuals amci recall comparable quantities information quality recalled information differs significantly theoretical grounds suggests existence distinct neurobiological neurofunctional manifestations groups practically differences may guide development personalized emotion focused encoding strategies cognitive training programs
satellite radio equipments require efficient radio frequency filtering solutions solve issues narrow bandwidth small size frequency temperature independence etc band pass filter based temperature stable bulk acoustic wave resonator designed fabricated tested filter presents decent insertion loss sharp skirt excellent temperature stability
alcohol substance drugs alcohol abuse major risk factors traumatic brain injury tbi however remains unclear whether outcomes differ without history preinjury abuse meta analysis performed examine issue pubmed embase psycinfo databases searched research compared neuroradiological cognitive psychological outcomes adults without documented history alcohol substance abuse sustained nonpenetrating tbis data studies analyzed using random effects model hedges effect sizes measured mean difference outcomes individuals without history preinjury abuse bayes factors assessed probability outcomes differed patients history alcohol substance abuse poorer neuroradiological outcomes including reduced hippocampal gray matter volumes enlarged cerebral ventricles limited differences cognitive outcomes executive functioning memory moderately affected attention reasoning findings fine motor ability construction perception general cognition language inconclusive postinjury substance alcohol use emotional functioning worse history alcohol substance abuse psychological outcomes study highlighted type extent post tbi differences persons without history alcohol substance abuse many may hamper recovery however variation criteria premorbid abuse limited information regarding history abuse absence preinjury baseline data prevented assessment whether differences predated tbi occurred result ongoing alcohol substance abuse reflected cumulative impact alcohol substance abuse tbi
first two studies provided validity data teacher irrational belief scale measures set beliefs teachers previous research found associated teacher stress employing sample primary secondary teachers australia exploratory factor analysis resulted four distinct factors self downing authoritarianism demands justice low frustration tolerance four sub scales demonstrated adequate internal reliability correlated self ratings stress occasioned different teaching stressors second study teachers teachers retired teaching stress completed teacher irrational belief scale measure teacher stress teachers retired teaching due stress scored higher sub scales self downing low frustration tolerance teachers still teaching results discussed terms ellis theory rebt implications consultants teacher educators offering stress management programs support teachers
study integrates emotion social influence literatures examine emotion recognition ability era relates annual income sample employee peer supervisor triads broad range jobs organizations find people level era indirectly relates much earn per year relationship era annual income mediated sequentially political skill interpersonal facilitation results imply emotional abilities allow people process affect laden information effectively also use information successfully navigate social world organizations pursuit prosperity copyright john wiley sons ltd
introduction henna tattoos common practice adolescent population henna often admixed para phenylenediamine ppda improve appearance tattoo ppda potent allergen frequent cause allergic contact dermatitis acd material method study conducted results consecutive children patch tested university general hospital consortium valencia results almost half cases children one positive patch test findings allergic ppda mean age patients allergic ppda years male cases atopic dermatitis positive reactions considered current clinically relevant sensitisation origin henna tattoo cases conclusion ppda sensitisation relatively common child adolescent population frequent origin performing henna tattoos adulterated ppda adolescents higher risk developing acd due henna tattoos henna tattooing strongly discouraged children asociacion espanola pediatria published elsevier espana rights reserved
tropical montane cloud forest tmcf hydrologically unique highly vulnerable ecosystem changes land use climate assessing impacts changes needs consider soil water dynamics particular organic layer functioning requires attention difference water retention characteristics root density compared underlying mineral soils higher root density higher water storage capacity organic layer compared mineral soils suggests nutrient water uptake occurs layer however hydraulic properties mineral soils impact hydrology tmcfs poorly studied provide organic layer water retention curves tmcf soils measured laboratory data assessed potential land use climate change impacts tmcf soil moisture dynamics land use change perspective estimated water storage capacity loss slash burn deforestation practices estimates show storage loss ranges tmcfs converted pastures several times higher estimated tmcf canopy storage capacity therefore higher peak flow observations deforested catchments might explained decreasing canopy water storage also likely due decreasing soil water storage climate change perspective evaluated effect contrasting dry season conditions soil moisture transpiration using water flow model assessed sensitivity hydrological variables uncertainties saturated hydraulic conductivity although transpiration limited soil moisture mild dry season affected severe dry season continued decline expected climate change prolongation dry spells results show organic layer key element tmcf hydrological functioning call increased focus role organic soils evaluating effects land use change elsevier rights reserved
lack user engagement absence user feedback incomplete continuously changing user requirements among critical concerns cause projects fail user centered design ucd agile software development two iterative approaches proposed overcome concerns ucd design process focusing user research user interface design usability evaluation introduced software engineering practitioners agile refers number iterative incremental software development practices emphasize people needs communication developers stakeholders ability adapt change agile ucd communities however full understanding user requirements often seen incompatible early quick development iterations performed literature review aiming identify agile teams integrated ucd tools agile software development process better understanding user requirements without losing sight agile values principles ucd tools adaptations minimal upfront design applied agile development among approaches discovered study findings could lead comprehensive user centric software engineering overcome inherent problems faced agile teams understand user needs priorities goals
serological cut exists separate low syndrome central hypothyroidism objective retrospective study propose cut first participant group comprised patients age six twenty years group consisted patients anorexia nervosa second participant groups comprised patients range ages hospital included patients respectively third group participants comprised patients hospital ages less eighteen years last group participants comprised patients two hospitals main outcome measure ratio respectively ratio first group significantly different cut value set sensitivity patients second group respectively cut value useful distinguishing age two years shown third group subjects last group aged years ranged conclusion less suggests rather patients age two eighteen years
levodopa dihydroxyphenylalanine dopa important neurotransmitter used treatment neural disorders parkinson disease abnormal dopa concentrations biological fluids used evaluation diseases work rapid sensitive method dopa detection reported based situ formation polylevodopa nanoparticles alkaline conditions dopa spontaneously oxidized quinone derivative shows fluorescence properties fluorescence signal oxidation product monitored used determination dopa presence dopamine uric acid ascorbic acid interferents developed assay shows excellent selectivity towards dopa limit detection lod method evaluated linear range elsevier rights reserved
limiting global warming well degrees requires transformation global energy system scale unprecedented since industrial revolution meet degrees goal integrated assessment models opt using bioenergy carbon capture storage beccs without beccs models predict goal either unachievable substantially costly meet modeling literature extensive studies key climate policy actors perceive prioritize beccs sparse article provides unique intercontinental mapping prioritization beccs long term transition electricity supply sector based survey responses climate change conference delegates article reports low prioritization beccs relative alternative technologies indicating urgent need studies sociopolitical preconditions large scale beccs deployment
death dopaminergic neurons major pathological hallmark parkinson disease elevated iron within substantia nigra brain thought catalyze neuronal death hydroxyl radical derived oxidative damage removing excess iron presents potential therapeutic strategy seventeen derivatives non toxic iron chelator desferrioxamine dfob prepared conjugation adamantyl deconstructed adamantyl units norborna bicyclo octane based ancillary fragments terminal amine group range experimental logp values logp greater water soluble dfob logp increased hydrophobicity designed improve cell membrane carriage facilitate intracellular iron sequestration first activity screen showed compounds methyl substituted adamantyl noradamantyl pentylbicyclo octane ancillary groups significantly rescued iron mediated oxidative stress confluent relevant neuroblastoma cells cells exposed dimethy bipyridinium paraquat second dose dependence screen ranked top candidates similar rescue treated cells ancillary fragments clustered region defined close zero dipole moment logp values surface area volume ratio results iron leaching studies indicate compounds may operating via mechanisms beyond solely removing intracellular iron dfob conjugates methyl substituted adamantyl ancillary groups top consistent performers class compound designed elsevier ltd rights reserved
digital watermarking protocols one combined fingerprinting technique watermarking embedding digital signal watermark original multimedia object buyer seller watermarking protocol fundamentally applied continue digital rights buyers seller proposed identity based buyer seller watermarking protocol encounters various weaknesses zhang watermarking protocol ensured pointing weaknesses inaccuracy minimised implementing buyer seller watermarking protocol suggested protocol uses based public key cryptography digital watermarking scheme place ownership digital content hence copyright protection attained claim suggested protocol efficient adequate security compared traditionally proposed protocols therefore suitable practical buyer seller watermarking scheme
background many young children spend significant portion day child care facilities may exposed contaminants linked adverse health effects exposure data volatile organic compounds vocs particulate matter settings scarce objective guide design larger exposure assessment study urban child care facilities conducted pilot study characterized indoor concentrations select vocs methods recruited child care facilities district columbia washington measured indoor concentrations seven vocs total samples samples per facility benzene carbon tetrachloride chloroform ethylbenzene xylene xylene toluene facilities collected real time measurements seven facilities calculated descriptive statistics contaminant concentrations computed intraclass correlation coefficients icc evaluate variability voc levels indoors also administered survey collect general health information children attending facilities information general housekeeping practices proximity facilities potential sources target contaminants results detected six seven vocs majority child care facilities detection frequencies ranging chloroform toluene detected samples median range concentrations toluene chloroform benzene xylene ethylbenzene carbon tetrachloride limit detection lod lod lod lod respectively iccs vocs measured ranged child care facility median concentrations respectively chlorine bleach source chloroform used almost facilities air fresheners scented candles used half facilities least one child facility physician diagnosed asthma median asthma prevalence rate conclusion found quantifiable levels vocs child care facilities sampled given exposures environmental contaminants critical developmental stages may long lasting impacts children health larger studies needed characterize identify sources exposures indoor contaminants develop exposure mitigation strategies elsevier inc rights reserved
background bisphosphonate therapy may actions beyond bone including effects cardiovascular immune muscle function tested whether bisphosphonate treatment associated improved outcomes older people undergoing inpatient rehabilitation methods analysis prospectively collected linked routine clinical datasets participants divided never users bisphosphonates use prior rehabilitation use rehabilitation current users use rehabilitation calculated change point barthel scores rehabilitation adjusting comorbid disease laboratory data using multivariable regression analysis cox regression analyses performed analyse association bisphosphonate use time death hospitalisation results patients included analysis current bisphosphonate users showed greater improvement barthel score rehabilitation non users points difference compared receiving bisphosphonates discharge previous bisphosphonate use significantly associated time death adjusted hazard ratio less strongly time combined endpoint hospitalisation death adjusted hazard ratio use discharge rehabilitation associated reduced risk death adjusted hazard ratio hazard ratio per year bisphosphonate prescription conclusion bisphosphonate use unlikely causally associated improved physical function older people continuing use may associated lower risk death elsevier rights reserved
background refusal oral polio vaccine opv difficulty faced polio eradication initiative pei multiple endemic areas including khyber pakhtunkhwa province kpp pakistan investigated community perceptions opv estimated prevalence opv refusal three districts swat valley kpp polio endemic area methods qualitative data concerning community perceptions collected focus group discussions among lady health workers lhws mothers children year old key informant interviews local health managers officials quantitative data collection followed using questionnaire survey lhws cluster sampling survey mothers per district children year old results qualitative assessments identified grounded theory opv refusal involving facts known residents related opv frequent opv campaigns opv boycott northern nigeria birth control viewed islam local interpretations facts perceptions opv contained birth control pork opv foreign central plot muslims vaccination hadith fate determined god different manifestations opv refusal among three districts studied proportion lhws encountered opv refusal ranged whereas among districts proportions mothers unwilling give opv children ranged refusal injectable vaccines almost equally prevalent reasons similar conclusions pei needs reflect local value system path polio eradication studied districts swat valley religious cultural values well interpretation international political situation particular importance elsevier ltd rights reserved
objective limited data assessment relationship sex hormones metabolic syndrome inflammation therefore objective examine relationship metabolic syndrome testosterone inflammation patients methods cross sectional study included subjects age range years blood analyzed plasma glucose serum lipids total testosterone high sensitivity reactive protein crp results patients metabolic syndrome without according modified ncep guidelines age bmi obesity dyslipidaemia smoking ldl low elevated crp significant independent predictors conclusions low testosterone high crp levels independent predictors metabolic syndrome elsevier masson sas rights reserved
produced water largest waste stream oil production process contains light polar aliphatic hydrocarbons production process compounds dissolved gases anions cations disposal subjected strict legislations oil producing countries focused finding effective economic methods treatment physical chenlical methods used treatment biological treatments proven efficiently remove dissolved hydrocarbon compounds coupling anaerobic biological treatment electrochemical technology microbial fuel cells mfcs principle lead production clean water electric energy suitability mfcs improving treatment investigated present work first time simple design single chamber mfcs fed real mfcs studied different configurations without membrane without cathodic catalyst results demonstrate effectiveness membraneless configuration without chemical catalyst cathode even though electrical output mfcs low currently best reported performance furthermore almost complete hydrocarbon degradation achieved fed cycle coulombic efficiency limited difficulty obtain strict anaerobic condition anode since biocathode mfcs remained permeable oxygen acetate fed mfcs dna sequencing operating anodic biofilm detected electroactive desulfobulbaceae mixed aerobic biodegraders burkholderiales likely cycling sulfur compounds enriched initial pool hypersaline environment results pointed practical possibility using mfc enhance monitor biodegradation process fact mfc electrical output indicated occurrence anaerobic degradation electrochemical parameters cathode tafel slope resulted correlated aerobic degradation suggesting possibility design line sensor biotechnological industrial treatments elsevier ltd rights reserved
introduction presence thrala polymorphism deiodinase thought several effects may influence enzymatic function associated increased expression genes involved oxidative stress brain tissue may predict favorable response combination levothyroxine plus triiodothyronine therapy hypothesized homozygous carriers ala allele different thyroid hormone parameters reduced health related quality life hrqol cognitive functioning methods participants lifelines cohort study genome wide genetic data available effects thrala polymorphism evaluated general population people treated thyroid hormone replacement therapy latter mainly primary hypothyroidism addition evaluating anthropometric data medication use existence metabolic syndrome hrqol assessed rand item health survey ruff figural fluency test used sensitive test executive functioning data thyrotropin free thyroxine free levels available subset participants results mean age standard deviation years body mass index users compared years participants general population ala ala genotype thrala polymorphism present users general population total subjects thyroid hormone data available normal tsh miu users females users higher lower lower ratio female patients lower scores hrqol domains physical functioning vitality mental health social functioning bodily pain general health compared using executive functioning scores part cognitive functioning comparable female users general population groups thrala polymorphism associated differences tsh ratio presence metabolic syndrome comorbidities use medication hrqol cognitive functioning conclusion thrala polymorphism associated thyroid parameters hrqol cognitive functioning general population participants thyroid hormone replacement therapy
progress degree integration analog filters realization filters characteristics modified external control desired paper presents method realizing systematically arbitrary grounded immittance floating immittance voltage transfer function means operational transconductance amplifiers ota variable voltage controlled current sources vccs grounded capacitor signal flow graph ota circuit represented terms integrator block unit graph mixed voltage current hand coates graph represent circuit configuration circuit characteristics easily computed graph means graph condition graph directly realize higher order function presented direct configuration method derived realize arbitrary function least number nodes floating immittance obtained direct configuration method simply replaced circuit device sensitivity reduced however low sensitivity configuration becomes possible differential input ota used transpose circuit defined input output ota interchanged method configuration shown multioutput circuits means transpose circuit finally validity present configuration method confirmed experiment
work presented paper data driven control used tune internal model control despite fact may contradictory apply model free method model based controller methodology successfully applied activated sludge process asp based wastewater treatment addition feedforward controller influent substrate concentration also computed using virtual reference feedback tuning applied wastewater process see effect dissolved oxygen substrate concentration effluent
maximum energy release rate criterion max criterion commonly used crack propagation analysis fracture criterion based elastic macroscopic strength materials present investigation however max criterion modified order accommodate consideration plastic strain energy modified criterion extended study fatigue crack growth characteristics mixed mode cracks predict crack propagation due fatigue loads new elasto plastic energy model presented new model includes effects material properties strain hardening exponent yield strength sigma fracture toughness stress intensity factor ranges results obtained compared obtained using commonly employed crack growth law experimental data
fortran output routine messy enables debugging error message processing strategies design numerical mathematical software supports separate output different processes parallel computing environment
farming among dangerous industries fatal nonfatal injuries comprehensive agricultural injury surveillance system absent north carolina data sets traditionally used provide estimates nonfatal farm injuries surveillance united states relatively incomplete absence comprehensive farm injury surveillance system individual local administrative data sources provide useful profile epidemiology injuries population objective study use emergency department data help describe burden farm related injuries explore usefulness conducting work related injury surveillance emergency department data north carolina disease event tracking epidemiologic collection tool detect utilized identify farm injury cases study sample included farm injury cases period contained international classification diseases ninth revision clinical modification icd code agricultural machinery place occurrence farm code excludes farm house home premises farm results indicated average cases farm injury occurred annually significant change years among patients male years old form insurance coverage injuries heavily concentrated piedmont coastal plains regions respectively farm coded incidents given injury poisoning related primary diagnosis codes frequent specific codes related open wounds upper limbs contusions sprains strains significant relationships diagnoses sex region age also identified injuries occurring farm well documented constitute significant public health problem exploring emergency department data provides opportunity better characterize nonfatal farm related injuries prevention purposes data provided study may serve direct prevention programs whereas methods used offer potential farm related injury surveillance tool
large scale data intensive web services evolving faster ever accelerating global growth data usage traffic rapid rate rapid growth demanding expansion high cost data infrastructures also underscores industry need cost effective high performance distributed key value stores designing key value stores often involves trade performance memory usage example many previous studies focusing minimizing memory usage developed disk indexing schemes leading lower performance alternative design based memory indexing allows better performance expense greater memory usage paper proposes novel key value store called phash packed hash based advanced design index data structures ensures high performance small memory usage advantages make proposed scheme better fit processing demanding workloads large scale data intensive applications compared best performing competitor fawn proposed scheme significantly reduces memory consumption bytes per key value improves get throughput put throughput decreases particular get performance proposed scheme reaches optimal performance raw ssd solid state drive elsevier inc rights reserved
variants gene encoding enzyme glutamic acid decarboxylase like gadl associated response lithium therapy gadl related enzyme cysteine sulfinic acid decarboxylase csad proposed involved pyridoxa phosphate plp dependent biosynthesis taurine present study compared catalytic properties inhibitor sensitivity expression profiles gadl csad brain tissue mouse human brain observed distinct patterns expression plp dependent decarboxylases csad gadl glutamic acid decarboxylase gad csad levels highest prenatal early postnatal development gadl peaked early prenatal development gad increased rapidly birth csad gadl expressed neurons whereas csad mrna detected astrocytes cysteine sulfinic acid preferred substrate mouse csad gadl although enzymes also decarboxylated cysteic acid aspartate silica screening molecular docking using crystal structure csad vitro assays led discovery eight new enzyme inhibitors partial selectivity either csad gadl lithium minimal effect enzyme activities conclusion taurine biosynthesis vertebrates involves two structurally related plp dependent decarboxylases csad gadl partially overlapping catalytic properties different tissue distribution indicating divergent physiological roles development selective enzyme inhibitors targeting enzymes important dissect patho physiological roles authors published elsevier ltd
optimal boundary control problem studied coupled parabolic pde ode systems linear quadratic method used exploits infinite dimensional state space representation coupled pde ode system linearization nonlinear system established around steady state profile using appropriate state transformations linearized system formulated well posed infinite dimensional system bounded input output operators shown resulting system riesz spectral system linear quadratic control problem solved using corresponding riccati equation solution corresponding eigenvalue problem results applied case study catalytic cracking reactor catalyst deactivation numerical simulations performed illustrate performance proposed controller elsevier ltd rights reserved
switched reluctance motor srm increasing prominence due simple rugged construction absence winding rotor low manufacturing cost high power density fault tolerant capability advantages srm overshadowed existence torque ripple noise vibration requirement rotor position information complex control due nonlinear characteristics paper presents new drive circuit switched reluctance motor controlling speed using intelligent technique like fuzzy logic controller flc flc turned critical system control building paper presents fuzzy logic controller speed control srm controller tracks exact speed response pid controller simulation results reveal flc gives better performance srm fuzzy logic controller quick reacted effectively altered less expensive execute require numerical modeling smooth speed tracing crest overshoot compared conventional controller
objective overt hypothyroidism confers increased risk non alcoholic fatty liver disease nafld liver plays crucial role metabolism cholesterol triglycerides thyroid hormones interact hepatic lipid homeostasis thyroid function within euthyroid range affects number health issues including atherosclerosis development biochemical markers increased cardiovascular risk however association thyroid hormones nafld euthyroid subjects unequivocally established therefore determined associations thyroid hormone parameters nafld among euthyroid subjects methods study conducted lifelines cohort study population based cohort study participants living north netherlands euthyroid subjects thyroid stimulating hormone tsh free thyroxine pmol free triiodothyronine pmol older years included exclusion criteria participants excessive alcohol use known hepatitis cirrhosis liver functions three times upper limit current cancer non white ancestry previous current use thyroid medication current use lipid glucose lowering medication priori defined liver biochemistry thyroid function parameters metabolic syndrome mets studied nafld defined using validated fatty liver index fli fli categorized nafld found individuals male median age years increased prevalence mets independently associated higher per increment lower tsh strongest association found ratio associations remained similar additional adjustment presence mets subjects enlarged waist circumference tsh lower higher resulting increased ratio conclusions euthyroid subjects suspected nafld characterized higher lower higher ratio probably consequent central obesity elsevier inc rights reserved
wheeled vehicles responsible substantial portion dissipated energy share tire ground interface among role playing elements regard vibrations kinetics traversing wheel obstacle paradigm serve functional example energy dissipation wheeled vehicles paper communicates analysis dissipated energy traveling wheel collision time obstacles controlled laboratory condition soil bin facility equipped single wheel tester rig utilized carry experiments tests conducted affected wheel load obstacle height obstacle geometry slippage speed inferred increment collision speed obstacle height tire slippage lead increase dissipated energy however complexity lies contradictory effect wheel load attributed nonlinear wheel dynamics vibration attenuation process emphasized outcome study would serve functional catalyst extensive researches concerned machine design industry heavy vehicle trafficking management elsevier ltd rights reserved
zero dimensional thermodynamic model simulation developed simulate combustion characteristics performance four stroke homogeneous compression combustion ignition hcci engine fueled gasoline model applies first law thermodynamics closed system inclusive empirical model predicting important parameters engine cycles combustion timing mass burnt fraction combustion process hypothesis increasing intake temperature reduce combustion duration fuel consumption wide range equivalence ratio intake temperature increased increment engine operated range equivalence ratios constant engine speed rpm intake pressure simulations performed using simulink different engine operating conditions increasing intake temperature allows reducing combustion duration degrees degrees equivalence ratios respectively brake specific fuel consumption decreases equivalence ratios thus fuel consumption reduced increasing intake temperature
introduction beam emerging gamma tomo source assembly simulated previous study authors reported spectra particles reaching plane immediately collimation system entrance present work simulate beam emerging novel gamma tomo sbrt collimation system calculate output factors dose rates different source configurations collimator sizes materials methods gamma tomo system includes source capsules source housing primary collimator different changeable collimators sources diameter located rows different angles distances longitudinal axis beams collimated obtain four different circular field sizes isocenter beam monte carlo code used realistically model collimation system geometry including primary collimator different changeable collimators previously calculated phase space file used transport particles throughout collimation system patient plane changeable collimators gama tomo system respective phase space files particles stored isocenter circular fields used input gepts perform dose calculations newly designed geometry module used determine dose distributions spherical polystyrene phantom radius centered isocenter results characteristics particle spectra emerging collimation assembly determined effect source collimator position spectra reaching isocenter found dependent field size observed differences energy spectra fluence distributions calculated different configurations source collimator assembly effect source collimator position observed dose distributions calculated isocenter dependent upon size circular field conclusions resulting data present study supports machine design process valuble building well represented source model sources perform dose calculations changeable collimators novel gamma tomo system
singular value decomposition svd tool widely used data denoising matrix approximation recommendation system text mining computer vision majority applications prefer sparse singular vectors capture inherent structures patterns input data results interpretable present novel penalty svd achieve sparsity comparing traditional penalties proposed penalty scale dimensional insensitive bounded favor controlling sparsity regulated penalty provide efficient algorithm project vector onto given sparse level expected time efficient projection algorithm serve drudge sparse svd ssvd experiments ssvd efficient could capture latent structures patterns input data
paper nonlinear current output digital analog converter dac employing pseudo exponential transconductance amplifier presented proposed transconductance amplifier makes use code dependent body biasing realize exponential relationship output current input digital signal cmos technology digital control unit designed provide linearly code dependent voltage feed transconductance amplifier charging capacitor period determined counter loaded input digital code proposed dac simulated standard cmos technology accuracy exponential input output characteristic verified curve fitting simulation results squared value fitted functions greater process temperature corners presented dac consumed worst case
new diffusion sign subband adaptive filtering algorithm individual weighting factor iwf dssaf subband proposed distributed estimation impulsive noise environment since inherent decorrelating property subband adaptive filtering fully used proposed algorithm obtains better performance terms convergence rate tracking capability compared diffusion sign subband adaptive filtering dssaf algorithm addition stability analysis iwf dssaf algorithm performed based price theorem order obtain faster convergence rate sparse distributed system identification improved proportionate iwf dssaf algorithm proposed gain distribution matrix incorporated iwf dssaf algorithm finally simulations carried distributed system identification context results simulations demonstrate proposed algorithms achieve better convergence performance counterparts
background late neovascular age related macular degeneration nvamd common causes irreversible severe visual loss unless treated swiftly vascular endothelial growth factor vegf inhibitors although publicly subsidized access treatment may inequitable assessed treatment provision across australia design secondary analysis australian data participants pharmaceutical benefits scheme including repatriation pbs beneficiaries methods treatment incidence data obtained medicare australia royal australian new zealand college ophthalmologists optometry australia blue mountains eye study australian bureau statistics data mapped using geographical information software factors associated treatment provision assessed using multiple linear regression models main outcome measure unmet need anti vegf treatment nvamd results average estimated incident cases nvamd treated per year total number ophthalmologists optometrists per beta confidence interval located remote regions beta associated percentage untreated cases higher proportion population speaking language english home associated univariate analyses beta conclusion large proportion incident nvamd treated anti vegf receiving treatment likely regional remote areas areas fewer service providers speaking english home may limit access service delivery models equitable service provision needed
purpose people high functioning autism hfa qualitative differences facial expression prosody production rarely systematically quantified authors goals qualitatively quantitatively analyze prosody facial expression productions children adolescents hfa method participants male children adolescents hfa typically developing controls males female authors used story retelling task elicit emotionally laden narratives analyzed use acoustic measures perceptual codes naive listeners coded productions emotion type degree expressiveness awkwardness results group hfa significantly different accuracy expressiveness facial productions significantly awkward group participants hfa significantly expressive vocal productions trend greater awkwardness severity social communication impairment captured autism diagnostic observation schedule ados lord rutter dilavore risi correlated greater vocal facial awkwardness conclusions facial vocal expressions participants hfa recognizable peers qualitatively different particularly listeners coded samples intact dynamic properties preliminary data show qualitative differences nonverbal communication may significant negative impact social communication success children adolescents hfa
dual frequency signals gps satellites recorded rajkot degrees degrees geographic degrees geomagnetic near equatorial ionization anomaly crest india analyzed study ionospheric variations terms total electron content tec low solar activity period april december study describe diurnal seasonal variations tec solar activity dependence tec effects space weather related event geomagnetic storm tec diurnal variation tec shows pre dawn minimum short period time followed steep early morning increase reaches maximum value mean diurnal variations different seasons brought found tec rajkot maximum equinoctial months march april september october minimum winter months november december january february intermediate values summer months may june july august showing semi annual variation tec values decreasing since onwards showing positive correlation solar activity tec variations geomagnetic storm commencing august analysed tec shows positive ionospheric storm effect first day storm negative ionospheric storm effect next day equatorial electrojet control development equatorial anomaly also demonstrated
women still underrepresented management men hold majority higher positions nonetheless one often heard claim popular media female people centered leadership skills empathy communication etc better match business world especially future furthermore related idea women may use advantage take men dominant position leadership four studies show claims paradoxically maintain gender inequality undermining support affirmative action reduce female underrepresentation leadership earlier research shows positive stereotypes hurt women suggesting unqualified leadership current findings show even positive stereotypes claim women particularly well qualified leadership hurt women chances gaining leadership positions although good highlight advantages female leadership exaggerated sensationalist claims contribute perpetuation gender inequality
influence violent video games associated aggressive criminal behaviours several situations present research pretends emphasize effect exposure violent car video game activation aggressive response post exposure anger levels sample adolescent people selected exposed violent video game non violent one minutes self reported anxiety anger levels measured video game exposures moreover performance indirect task aggression main effect age interaction sex kind video game found aggressive task likewise pre postest effect state anger levels observed hand predictor model aggressive response elicitation found age pre exposure anger factors conclusion outstanding short term priming effect violent video games aggressive behaviour violent video game exposure existence modulating factors effects violent contents could clarify features help predict criminal behaviours
coating chloroplasts conjugated polymer nanoparticles cpns new bio optical hybrid photosynthesis system chloroplast cpns developed since cpns possess unique light harvesting ability including ultraviolet part chloroplasts absorb less chloroplast cpn complexes capture broader range light accelerate electron transport rates photosystem psii critical protein complex chloroplasts augment photosynthesis beyond natural chloroplasts degree spectral overlay emission cpns absorption chloroplasts critical enhanced photosynthesis work exhibits good potential explore new facile nanoengineering strategy reforming chloroplast light harvesting nanomaterials enhance solar energy conversion
concept safety factor nearly universally applied structural engineering presently several approaches probabilistic interpretation safety factors literature herein generalize approaches derive four possible definitions safety factor based fuzzy sets central fuzzy safety factor defined ratio centroid abscissas membership functions respectively capacity demand structure characteristic value fuzzy safety factor lower bound cut fuzzy safety factor specified level membership function mean value fuzzy safety factor centroid abscissa fuzzy capacity demand ratio fuzzy multiplicative safety factor defined abscissa centroid capacity multiplying abscissa centroid inverse demand fundamental problem strength materials namely tension element subjected axial load analyzed context four fuzzy safety factors
osteopenia osteoporosis young adults beta thalassemia major btm prominent cause morbidity despite adequate transfusion iron chelation therapy reported frequency varies additional affected osteopenia pathogenesis btm multifactorial related chronic anaemia secondary bone marrow expansion associated endocrinopathies nutritional deficiencies genetic factors factors lead osteoporosis increasing osteoclast activity impairing osteoblast function prominent cause morbidity btm increased risk vertebral long bone fractures although bisphosphonates used treatment osteoporosis btm cases poor clinical response new fractures occurring treatment therefore least patients suggest decreased bone formation predominant mechanism btm induced anabolic treatment could appropriate therapy
release transport leachate municipal solid waste landfills pose potential hazard surrounding ecosystems human populations present study soil groundwater surface water samples collected periphery municipal solid waste landfill located ranital jabalpur madhya pradesh india laboratory analysis understand release contaminants landfill receive solid wastes dumping landfill closure plan groundwater soil samples collected bore holes deep drilled along periphery landfill surface water samples collected existing surface water courses near landfill landfill neither bottom liner leachate collection treatment system thus leachate generated landfills finds paths groundwater surrounding surface water courses concentrations various physico chemical parameters including toxic metals collected groundwater soil surface water samples microbiological parameters surface water samples determined analyzed data integrated arcgis environment spatial distribution metals physic chemical parameter across landfill extrapolated observe distribution statistical analysis spatial variations indicated leaching metals landfill groundwater aquifer system study help readers municipal engineers understand release contaminants landfills better management municipal solid wastes elsevier rights reserved
last decades assisted called information explosion advent new technologies new contexts volume velocity variety data increased exponentially becoming known today big data among emphasize telecommunications operators gather using network monitoring equipment millions network event records call detail records cdrs event detail records edrs commonly known xdrs records stored later processed compute network performance quality service metrics ever increasing number collected xdrs generated volume needing stored increased exponentially making current solutions based relational databases suited anymore tackle problem relational data store replaced hadoop file system hdfs however hdfs simply distributed file system way supporting aspect relational paradigm overcome difficulty paper presents framework enables current systems inserting data relational databases keep transparently migrating hadoop proof concept developed platform integrated altaia performance qos management telecommunications networks services
design fuzzy based hierarchal approach proposedto improve frequency control power system simplified great britain frequency control model used single bus machine new simple tuning method proposed aid conventional pid controller gains gains used feed fuzzy controller loop without tuning fuzzy gains method allows fuzzy structure supplement conventional control rather replacing particle swarm optimization pso proposed find optimal value controller gains five modeling scenarios fuzzy control two cases uncertain parameters considered validate model structures fuzzy controller offered high stability robustness simulation results therefore proposed hierarchal structuresare used real time applications load frequency control power systems elsevier rights reserved
ambient intelligence environments technologically augmented surroundings aim provide personalized services users based context identifying services users become increasingly challenging task overwhelming number services ambient environment made selection management services even challenging address problem researchers proposed several techniques creating user model selecting services based model applying rule based approach match relevant services utilizing combination user profile context interaction history service reputation select best services user techniques obtain preference user based interaction profile consider power collaborative selection approach paper propose use collaborative recommendation technique select services user based multiple users interactions profile accordingly demonstrate potential proposed approach preliminary experiment
recent advances manufacturing based sacrificial fiber template techniques allowed complex networks microchannels embedded microvascular composites thermal application interest novel battery packaging scheme electric vehicles considered battery surrounded microvascular composite panels temperature regulation structural protection use simplified thermal hydraulics models validated complex fluent simulations experiments obtain surface temperature distribution panel pressure drops across microchannels eliminate cost complexity associated mesh generation applying interface enriched generalized finite element method igfem allows non conforming mesh capture discontinuous temperature gradient across microchannels igfem thermal solver combined gradient based shape optimization scheme obtain optimal designs set branched microchannel networks design parameters channel control points define shape network use mean differentiable objective function place maximum temperature obtain accurate gradients respect design parameters efficiently perform sensitivity analysis based recently developed adjoint method igfem starting many distinct configurations obtain optimal designs wide range network topologies also investigate effect coolant flow rate optimal design elsevier ltd rights reserved
aim paper generate nanotopological structure power set vertices simple digraphs using new definition neighbourhood vertices linked digraphs based neighbourhood define approximations subgraphs graph new nanotopological graph reduction symbolic circuit analysis developed paper means structural equivalence nanotopology induced graph framed algorithm detecting patent infringement suit
benefits using infrastructure environments cloud grid high performance computing performing scientific experiments could quite significant particular modeling simulation serve key decision making system analysis tool could benefit immensely environments ranging issues community practice could access simulation could run quickly however access use infrastructure environments may present completely different set challenges especially non information communications technology ict users science gateways digital interfaces advanced technologies used overcome challenges running many simulations infrastructures reasonable amount time work developed based liferay portal framework catania grid cloud engine show agentbased infection simulation implemented using recursive porous agent simulation toolkit repast simphony ported science gateway deployed distributed computing infrastructures demonstration illustrates technology used easily allow multiple users across world access simulation execute applications infrastructures environment
farmers must consider real world problems variability maximize yields minimize environmental impacts using cover crops corn zea mays based cropping systems much variability encountered farmers midwest corn belt due topographical diversity undulating landscape objectives study explore effects cover crops soil organic carbon total organic labile form particulate organic poc water retention contrasting topographies summit slope depression cereal rye secale cereal cover crop established fall two experimental sites site experimental design split split plot whole plot factor topographical position randomized complete block design two replications topographical position affected studied plant soil characteristics including aboveground plant biomass rye residue decomposition poc total soil soil water retention across topographical positions rye residue decomposition similar greater treatment without cover crop slopes summits poc treatment cover crop significantly similar soil similar ppm greater treatment without cover crop however difference statistically significant depressions cover crop effect total organic soil water retention levels statistically significant study points potential interactions topography sequestration benefits cover crops however longer experimental times needed detect significant differences soil total water retention measurements
united states black white individuals show discrepant rates diagnosis bipolar disorder versus schizophrenia antisocial personality disorder well disparate access utilization treatment disorders alegria chatterji chrishon anderson arora bailey diagnostic discrepancies might stem racially related cognitive biases clinical judgment racial biases measurements bipolar disorder general behavior inventory gbi among well validated widely used measures bipolar mood symptoms psychometric properties gbi examined primarily predominantly white samples study used multigroup confirmatory factor analyses cfa examine invariance gbi scores across racial groups nonclinical sample fit acceptable tests configural invariance equal factor loadings equal intercepts invariance residuals findings indicate gbi scores provide functionally invariant measurement mood symptoms black white samples use gbi scores may contribute consistent information clinical assessments could potentially reduce diagnostic discrepancies associated differences access utilization mental health services
paper global operating point dependent losses induction machines studied utilizing local transient loss formulation calculating local loss distribution losses integrated space averaged time get average global losses main loss components ohmic losses iron losses friction losses considered ohmic losses stator rotor dependent current values time local waveform due current displacement iron losses highly dependent flux density base frequency harmonic distortion flux density level flux machine operated depends operation mode inverter hence precise loss modeling inverter driven induction machines machine design stage time spatial distribution flux density influence choosing best operating point included
surgical treatment long proximal ureteral stricture challenging situation reconstructive surgeons despite underlying morbidities ileal interposition autotransplantation options available treat complex cases long segment ureteral stricture buccal mucosa shown excellent results urethroplasty however use ureteral reconstruction infrequent report year old female patient multiple comorbidities prior abdominal surgeries crohn disease underwent successful total substitution long segment proximal ureter using buccal mucosa regular postoperative isotope scans showed improvement renal function based pleasant outcome case review literature buccal mucosa might viable option low morbidity selected cases
aims objectivesthe aim study describe healthcare professionals experiences perceptions intervention implemented action research project conducted improve nursing documentation practices four municipalities norway backgrounddocumentation individualized patient care continuing concern healthcare services could impacts quality safety healthcare use electronic systems made aspects documentation comprehensive creation individualized care plan remains pressing issue designa qualitative descriptive design used methodsan action research project conducted improve content quality nursing documentation community healthcare services four municipalities one year project completed four focus group interviews conducted healthcare professionals one involved municipality two unit managers interviewed individually qualitative content analysis used resultsthree themes emerged healthcare professionals perceived competing interest experienced manage complexity changes highlighted clear visible leader important success conclusionsquality improvement activities essential healthcare professionals experience complicated situation electronic health record systems support workflow research recommended focus functionality user interface electronic health record systems role leadership implementing changes clinical practice relevance clinical practicestronger cooperation among policymakers electronic health record system vendors healthcare professionals essential improving electronic health record systems documentation practices involvement end users improvements make difference way systems perceived clinical workflow
recent research highlights patient engagement conceived patient behavioral cognitive emotional commitment care management key issue implementing new technologies healthcare process indeed ehealth interventions may systematically fail patient subjective experience taken consideration since first steps technology design present contribution argue issue crucial regarded field ambient intelligence ami specifically exact concept technologies embedded patients surrounding environment implies strong impact everyday life perceived limitation autonomy privacy therefore refused even openly opposed final users present contribution tackles issue directly highlighting theoretical framework include patient engagement design ami technologies assessment measures patient engagement developing testing effectiveness ami prototypes healthcare finally contribudon provides overview main issues emerging implementing ami technologies suggests specific design solutions address elsevier inc rights reserved
structural health monitoring shm gained popularity recent years since assess performance condition instrumented structures real time provide valuable information asset manager owner operational modal analysis plays important role shm involves determination natural frequencies damping ratios mode shapes constructed structure based measured dynamic data paper presents operational modal analysis seismic response characterization tsing suspension bridge long subjected different earthquake events three kinds events short distance middle distance long distance earthquakes taken account fast bayesian modal identification method used carry operational modal analysis modal properties bridge identified compared use field monitoring data acquired earthquake type events research emphasis given identifying predominant modes seismic responses deck short distance middle distance long distance earthquakes respectively characterizing response pattern various structural portions deck towers main cables etc different types earthquakes since bridge long seismic wave would arrive tower anchorage basements two side spans different time instants behaviors structural dynamic responses tsing side span wan side span type earthquake events compared results obtained study would beneficial seismic design future long span bridges built around hong kong hong kong zhuhai macau bridge
aside well known biologically active angiotensin biologically active angiotensins discovered including angiotensin angiotensin years ago others discovered mas proto oncogene encodes protein coupled receptor essential angiotensin signaling mas expressed periphery also within brain dentate gyrus piriform cortex since capable adult neurogenesis examined impact deletion mas upon adult neurogenesis deletion mas alter cell proliferation adult monitored phosphohistone alter cell death monitored activated caspase however mas deficiency resulted increase number doublecortin dcx positive cells indicating lack mas increases number cell population concerning discussed whether adult neurogenesis occurs physiological conditions area could demonstrate mas deficiency impact cell division population dcx positive cells within since mas expressed birth within brain data may suggest adult hippocampal neurogenesis neurogenesis occurring prenatal development share several common mechanisms least part differentially regulated moreover since deficiency mas increases numbers dcx positive young neurons blockage mas might beneficial stimulating neurogenesis adults elsevier ecnp rights reserved
across broad range design professions extensive research design practices considerable progress creating new computer based systems support design work research focused educational instructional design students learning sub field progress limited particular neither research systems development paid much attention fact design becoming collaborative endeavor paper reports latest research outcomes educational design studio eds facility developed iteratively four years support understand collaborative real time present design work eds serves enhance scientific understanding design processes design cognition provide insights designers work improved appropriate technological support study presented introduced complex multi user digital design tool existing ecology tools resources available eds analysed activity four pairs teacher designers design task identified different behaviors reconfiguring task working methods toolset usage data provide new insights affordances different digital analogue design surfaces used studio elsevier ltd rights reserved
purpose study investigate effect pretreatments heat ultrasound combinations heat ultrasound hpup ultrasound heat uphp protamex catalyzed enzymolysis corn gluten meal cgm enzymolysis kinetics molecular conformation microstructure cgm protein monitored enzymolysis reaction rate increased increasing substrate concentration resulted highest hydrolysis reaction rate best improvement cgm enzymolysis obtained hpup value decreased followed uphp value decreased fluorescence spectra fourier transform infrared ftir spectra indicated cgm pretreatments induced molecular unfolding exposing hydrophobic groups hpup uphp pretreatments decreased helix content increased random coil content respectively scanning electron microscopy atomic force microscopy showed hpup uphp changed surface topography distribution protein particles enhancing rate enzymolysis conclusion combined ultrasound heat pretreatment controlled enzymolysis could effective method functionality modification globular proteins elsevier ltd rights reserved
nitric oxide center dot dependent pathways cerebrovascular dysfunction shown contribute cognitive decline neurodegeneration observed alzheimer disease whether represent initial factors later changes disease still matter debate work aimed investigating whether extent neuronal derived center dot signaling related neurovascular coupling impaired along aging hippocampus triple transgenic mouse model alzheimer disease xtg performed longitudinal study combining behavior studies vivo simultaneous measurements center dot concentration gradients cerebral blood flow cbf along detection synthase nos markers nitroxidative stress results revealed impairment neurovascular coupling along aging xtg mice preceded obvious cognitive decline impairment characterized diminished cbf changes response normal even increased center dot signals associated markers nitroxidative stress results suggest impairment neurovascular coupling primarily due cerebrovascular dysfunction rather due dysfunctional signaling neurons blood vessels overall work supports cerebrovascular dysfunction fundamental underlying process pathology elsevier inc rights reserved
understanding development skull deformity requires understanding normal morphogenesis cranium craniosynostosis premature pathologic ossification one cranial sutures leading skull deformities review english medical literature using textbooks standard search engines performed gather information prenatal development growth cranial vault neurocranium process morphogenic sequencing begins prenatal development growth continues postnatally contributes basis differential manner growth cranial vault bones improved knowledge might facilitate comprehension pathophysiology craniosynostosis
smartphones become integral part daily life businesses offer services smartphones users also store sensitive personal information smartphones perform financial transactions consequently security attacks smartphone platforms also increased significantly traditional desktop anti virus software effective smartphones due restrictive security model heavily dependent definition updates paper propose secure anti malware framework sam smartphone operating systems prevent malicious activities core idea framework resembles smart city framework acts government city treats applications citizens components enforce laws prevent perform policing monitor control also provides apis aid anti virus software third party applications leverage functionalities framework goal design operating system framework hinders malicious activities thus protects user resources
transmission network switching proposed literature way improve social welfare liberalized power markets moreover exercise market power strategic generating companies gencos causes extra cost electricity market alleviated implementing appropriate switching policies paper contributes existing literature developing mathematical model explores economic perspective transmission network switching context market power strategic gecnos modelled based cournot game nash equilibrium game gencos formulated equilibrium problem equilibrium constraint epec epec problem transformed mixed integer linear feasibility problem handle multiple nash equilibria situations solution concept extremal nash equilibrium ene introduced mixed integer linear program milp derived finding ene transmission switching decisions modelled binary variables controlled system operator tso tso minimizes system dispatch cost calculated ene network reconfiguration cost tso minimizes cost using transmission switching decisions problem faced tso mixed integer bilevel linear program miblp binary variables upper lower levels upper level models tso action lower level oligopolistic gencos competing cournot game parallel branch bound technique used solve developed miblp model illustrative bus example system ieee rts modelled carefully studied numerical results demonstrate parallel branch bound technique effectively solve developed miblp using developed model system operator change topology network switching lines order reduce adverse effect strategic behaviour gecnos elsevier rights reserved
article presents overview future uses biologic therapies treatment immunologic allergic conditions discussion centered use existing therapies outside current indication new therapies close approval information may help familiarize practicing allergists immunologists therapies may soon encounter practice well help identify conditions treatments require study near future
objective describe historical refinements understanding physiology clinical outcomes observed thyroid hormone replacement strategies methods medline search initiated using search terms levothyroxine thyroid hormone history levothyroxine mono therapy thyroid hormone replacement combination therapy levothyroxine bioequivalence pertinent articles interest identified title available abstract review additional references identified course review literature identified results physicians intervened cases thyroid dysfunction two millennia ingestion animal thyroid derived preparations long described scientifically documented last years refinements hormone preparation pharmaceutical production regulation continue day literature provides documentation physiologic pathologic clinical outcomes reported continuously updated recommendations effective safe use hormones reversal patho physiology associated hypothyroidism relief symptoms hypothyroidism documented progressive refinement understanding thyroid hormone use studies thyroid hormone metabolism action pharmacokinetics allowed evermore focused recommendations use clinical practice levothyroxine mono therapy emerged therapy choice recent major guidelines conclusions evolution thyroid hormone therapies significant extended period time thyroid hormone replacement useful treatment hypothyroidism recent guidelines major endocrine societies recommend levothyroxine mono therapy first line use hypothyroidism
internet things iot environment everywhere every device became smart smart world internet things growing vastly implemented using smart devices involve embedded systems ess real time operating systems rtos used ess development due rtos added important features rtos simplifies development makes systems reliable many researches directed internet things rtos became part iot development paper generic vision architecture rtos iot way could implemented different applications presented implementation testing methods rtos iot discussed finally research directions using rtos iot discussed
level virtualization often used server consolidation data centers high efficiency however sharing storage stack services among colocated containers incurs contention shared kernel data structures locks within stack leading severe performance degradation manycore platforms incorporating fast storage technologies ssds based nonvolatile memories article presents multilanes virtualized storage system level virtualization manycores multilanes builds isolated stack top virtualized storage device container eliminate contention kernel data structures locks thus scaling manycores meanwhile propose set techniques tune overhead induced storage device virtualization negligible scale virtualized devices manycores host scales poorly reduce contention within single container propose sfs runs multiple file system instances proposed virtualized storage devices distributes files directory among underlying file system instances stacks unified namespace top evaluation prototype system built linux container lxc core machine ram disk modern flash based ssd demonstrates multilanes scales much better linux micro macro benchmarks bringing significant performance improvements multilanes sfs reduce contention within single container
liquid crystal elastomers lces exciting kind smart material convert thermo opto stimuli mechanical actuations paper formulate opto mechanical constitutive relation soft lces different director orientations shows soft material becomes transversally isotropic quasi soft light illuminations also opto strains produced consider plane stress problems simplification director variation depth beam shaped lces detailed finite element simulations two dimensional free standing samples indicate direction magnitude light induced bending strongly depend orientation director lces behave completely soft light illuminations critical orientation director namely samples deform stress freely shear without bending results show large shear deformation inevitably produced due rotation director means cross section plane remain normal middle line deformation even distortions may happen cross sections particularly orientation parallel perpendicular direction light propagation
analysis multitemporal remote sensing imagery offers reliable cost effective means monitoring crops broad scale provides consistent temporal measurements fractal geometry used quantitative description spatial complexity remote sensing images yet corn field spatial irregularity alters fractal dimension landscape shall suppressed estimation paper propose method computing fractal dimension irregular region interests minimizes contribution spatial irregularity method evaluated normalized difference vegetation index products derived moderate resolution imaging spectroradiometer satellite pour observation terre vegetation sensors three states experimental results using time series demonstrated proposed fractal dimension estimation method exhibited great consistency invariance change image spectral characteristics spatial resolution degree pixel mixing contrast entropy variance spectral characteristics different imaging devices exhibited lower impact fractal dimension also implies scale invariance respect detection rate first peak fractal dimension achieved best consistency proposed method computing fractal dimension provides critical reliable measure studying phenological patterns
building projects consume large amount energy resources emit solid waste harmful eco environment order study eco environmental impact green building development policies green building eco environment gbe model constructed method system dynamics implemented using vensim software model used simulate evaluate current state future trend variation eco environmental impact green building development wuhan years current green building development policies policy factors adjusted simulation determine optimal green building development policies quality regional ecological environment wuhan would improved economically elsevier ltd rights reserved
according self determination theory individual goal content processes involved goal setting often represent status individual mental health well examining importance placed goal setting individual goals aspirations often synonymous mental health well aspiring achieve intrinsic life goals associated greater psychological well literature study therefore aimed establish relationships goals aspirations mental health behaviour interpersonal relations stress management spiritual growth psychological well measured positive affect sample secondary school learners overberg educational district western cape south africa participated study results suggest significant positive relationship placing importance intrinsic goals aspirations psychological well indicated positive affect however psychological well correlated mental health behaviour results hierarchical regression analysis suggest importance placed intrinsic goals aspirations predicts psychological well accounts variance results highlight role intrinsic goals aspirations predicting psychological well adolescents findings supported theoretical assumptions self determination theory
light emitting diode led luminaires provide compelling benefits long term cost savings safety advantages longer life durability led luminaires lower maintenance costs improved instant restrike capability compared legacy luminaire types industrial applications proven lower total cost ownership increased safety leds driving forces led luminaires replace traditional light sources new technology challenges exist designing maintaining optimal system withstand intended application environmental conditions common challenges considerations include luminaire placement intensity dispersion quality light thermal management material selection redundant safety operating systems authors examine best practices common misconceptions selection application led luminaires focusing process harsh hazardous locations probability success maximizing reliability safety efficiency led technology applications enhanced utilizing proven design principles methods selection methods design principles explained using actual application examples case studies
notion negative childhood experiences sources toxic stress short long term consequences children health well gained increasing attention recent years family environment key source stress particularly parents inflict pain children pain rises level physical abuse stress thought toxic article author considers possibility nonabusive physical punishment may also constitute source toxic stress lives children affects brain structure functioning research linking physical abuse physical punishment children brain structure functioning summarized article concludes discussion implications future research policy practice
study improved butterfly structure address generation method fast fourier transform fft presented proposed method uses reduced logic generate addresses avoiding parity check barrel shifters commonly used fft implementations general methodology radix point transforms derived signal flow graph point fft presented furthermore case study point fft bit complex numbers synthesized using cmos technology circuit gate count analysis indicates significant logic reduction achieved improved throughput compared conventional implementations
rate thermally activated dislocation motion across field solutes studied using traditional modern atomistically informed rate theories first accuracy popular variants harmonic transition state theory common approach examined comparing predictions direct simulations shown htst predictions grossly inaccurate due anharmonic effect thermal softening next utility transition interface sampling examined method recently shown effective predicting rate dislocation precipitate interactions dislocation solute interactions studied tis found accurate dislocation overcomes multiple obstacles time jerky motion inaccurate unpinning regime energy barrier diffusive nature shown partial path tis method designed diffusive barriers provides accurate predictions unpinning regime two methods used study temperature load dependence rate shown meyer neldel rule prediction entropy barrier accurate case dislocation precipitate interactions response alternative model proposed provides accurate prediction entropy barrier model combined tst offer attractively simple rate prediction approach lastly tis used predict strain rate sensitivity srs factor experimental strain rates predictions compared experimental values acta materialia inc published elsevier ltd rights reserved published elsevier ltd rights reserved
endometriosis uncommon disease postmenopausal women pmw ranging cases important exclude neoplastic transformation endometrium authors would like introduce case year old overweight patient abdominal pain associated pain swelling left inferior limb occurring approximately six weeks ray abdomen revealed presence retroperitoneal mass causing deep vein thrombosis extrinsic compression left iliac vein following removal pelvic masses laparotomy histological exam revealed endometriosis ray carried month postoperatively revealed root canal treatment left femoral vein considerable decrease thrombosis homolateral external iliac veins despite endometriosis uncommon women reached menopause must considered differential diagnosis pelvic masses
sizing comparison among axial flux permanent magnet afpm motors presented adopted procedure implementing traditional sizing equations simple quick aimed reduce free design parameters basic parametric analysis obtain improved design procedure already applied design wind energy afpm synchronous generators used size afpm synchronous motor automotive application rotor disposition single stage axial flux interior rotor afir structure also called kaman type machine two stators consist laminated core concentrated coil windings
nontuberculous mycobacteria common microorganisms nature particularly found soil water cause pulmonary infections lymphadenitis disseminated infections localized skin soft tissue infections tendon bone articular infections catheter infections mycobacterium xenopi categorized slow growing mycobacterium pulmonary infections caused xenopi found associated chronic obstructive pulmonary disease copd underlying diseases bronchiectasis immunosuppression article aims present atypical mycobacterial infection patient anti tumor necrosis factor alpha therapy planned followed diagnoses ankylosing spondylitis copd
overweight proposed risk factor psoriasis ever evidence prospective studies limited aim study investigate association tween overweight weight gain risk psoriasis potential synergism smoking within population based cohort including individuals followed increased odds psoriasis body mass index bmi multi variable logistic regression analysis increasing bmi bmi non smokers dose response association weight gain age years higher odds psoriasis middle age independent weight category indication synergism overweight smoking interaction sex overweight weight gain represent modifiable risk factors may targets primary prevention psoriasis
retrospectively investigated occurrence crohn disease cohort patients parkinson disease based observation lrrk shared genetic risk factor identified patients crohn disease number consistent number cases expected general population elsevier ltd rights reserved
cell host immune response hepatitis virus hcv suggested play important role determining hcv infection outcome however data human studies available study examined effect primary cell deficiency along factors spontaneous clearance hcv large population based cohort british columbia canada hepatitis testers cohort includes individuals tested hcv linked data medical visits hospitalizations prescription drugs hcv positive individuals least one valid hcv pcr test hcv diagnosis included study examine factors associated spontaneous clearance hcv multivariable logistic regression fitted full sample cox proportional hazards model hcv seroconverters spontaneous clearance observed tested hcv adjusting potential confounders odds spontaneous clearance hcv lower people primary cell immunodeficiency adjusted odds ratio aor higher females aor coinfected hbv aor similar results observed hcv seroconverters except hbv coinfection significant conclusion primary cell immunodeficiency associated lower spontaneous clearance hcv female sex coinfection hbv associated higher spontaneous clearance
adaptive feedforward control common approach handling uncertainties time varying effects automotive control applications adaptation feedforward controller usually formed lookup table often combined linear feedback controller feedforward controller used overcome nonlinearities due variations operating point feedback controller used deal fast disturbances system behavior changing example due varying fuel qualities aging effects feedforward controller adapted common problem fact bandwidths feedback controller adaptation feedforward controller separated adaptation feedforward controller slower feedback controller otherwise coupling effects lead unexpected behavior control system may also lead instability paper presents analysis effect using linear representation adaptation feedforward controller based results analysis paper presents method decouple feedback controller adaptation feedforward controller allows fast adaptation feedforward controller ideally adaptation fast feedback controller system able adapt operating point transients without need stay operating points longer periods proposed method depend structure feedforward controller depend method adaptation experiments natural gas diesel dual fuel engine used validate proposed method
pilot study assessed whether clinicians urban college health center met reproductive needs emergency contraception contraception students physicians nurse practitioners completed item survey prescribing emergency contraception contraception clinician prescribing practices varied may resulted contraceptive needs students met timely manner clinicians different understandings policies prescribing contraceptives call students called students graduated education policies handling contraception requests necessary clinicians meet students reproductive health needs
polyurethane foam materials widely used cores sandwich composites packing cushioning main characteristics foams light weight high porosity high crushability good energy absorption capacity paper presents experimental results obtained mechanical properties polyurethane foams different loading conditions influence impregnation mechanical properties density polyurethane foam investigated experimental program three different strength materials laboratories lublin bucharest timisoara paper assesses possibility describe polyurethane foam behaviour trough compression tests micromechanical models finite element analysis fea micromechanical models finite element analysis could used successfully representing engineering stress strain behaviour compression tests provide reliable material parameters
background pegylated interferon alpha peginf alpha treatment patients polycythemia vera essential thrombocythemia resulted long term clinical response decreased jak allelic burden restoration polyclonal hematopoiesis mechanisms beneficial effects peginfa clear available evidence suggests direct suppression jak mutated clone induction dormant stem cells proliferation augmentation immune effect clones methods analyzed phenotype frequency peripheral blood lymphocytes pbl peginfa treated patients compared patients treated hydroxyurea samples collected various time points treatment analyzed using multicolor flow cytometry results found peginf alpha increased frequency peripheral blood foxp regulatory cells treg highly suppressive treg characterized expression hla also increased pbl peginfa treated patients observed augmentation cycling cells cells poorly activated cells results also suggest peginfa increased frequency helper cells foxp treg cells none changes present treated patients analyzed correlation changes different cell populations peripheral blood changes jak allelic burden clonal granulocytes augmentation treg hla treg helios treg hla cells correlated increase jak allelic burden also found positive correlation treg jak allelic burden however number available patients small conclusions report marked changes frequencies pbl subsets peginfa treatment suggesting immunomodulatory effect peginfa generation suppressive immune response measured increase highly suppressive treg poorly activated cells correlated poor molecular response study identified changes pbl would indicate presence effective anti tumor response
article develops state space method estimating integrated variance existence market microstructure noise mmn method based state space representation noise contaminated ncrv namely realized variance calculated observed prices contaminated mmns main idea method filter bias component call microstructure noise component ncrv using kalman filter apply proposed method yen dollar exchange rate data find half variation ncrv component proposed method serve convenient way estimate general class continuous time stochastic volatility models existence mmn
serpinopathy characterised abnormal accumulation serine protease inhibitors serpins cells results clinical symptoms owing lack serpin function excessive accumulation abnormal serpin recently identified patient functional deficiency plasminogen activator inhibitor pai member serpin superfamily patient exhibited life threatening bleeding tendencies also observed patients complete deficiency pai sequence analysis revealed homozygous singlenucleotide substitution guanine cytosine exon changed amino acid residue glycine arginine glyarg glycine located strand well conserved serpins mutant pai polymerised cells interfering pai secretion corresponding mutations serpinc anti thrombin iii position glyarg serpini neuroserpin position glyglu caused anti thrombin deficiency severe dementia due intracellular retention polymers glycine smallest amino acid mutated amino acids larger charged determine factors important mutagenesis pai performed although secreted secreted results revealed size likely triggered polymerisation seprins position structural analyses mutated pai would useful develop novel pai inhibitor may applicable context several pathological states
background previous studies indicated ramosetron hydroxytryptamine receptor antagonist achieves global improvement irritable bowel syndrome ibs symptoms male patients ibs diarrhea ibs however addition global assessment deemed important assess clinically meaningful improvements focusing patient chief complaint severity major ibs symptoms performed randomized placebo controlled phase pilot study explore examine efficacy variables allow evaluation ramosetron male patients ibs methods performed prospective study male outpatients ibs according rome iii criteria june december centers japan one week baseline period subjects received either ramosetron placebo daily weeks evaluate clinically meaningful improvements focusing severity major ibs symptoms japanese version ibs severity index ibssi used results change ibssi overall score baseline ramosetron group placebo group last evaluation point differences responder rates least reduction baseline ibssi ramosetron group placebo group except month monthly responder rate global assessment relief overall ibs symptoms ramosetron group showed statistically significant improvement compared placebo second month proportion patients reduction ibssi overall score responder group global assessment non responder group week conclusions examination needed ibssi used clinical trials agents ibs however study revealed response global assessment correlated improvement ibssi suggesting global assessment reflects improvement
relationship quality often declines following birth child likely reflecting part shift towards role traditionalization occurs gender specialization current study used longitudinal data fragile families child well study urban birth cohort consisting structured interviews mothers fathers followed years examine whether low levels fathers involvement coparenting two indicators role traditionalization linked negative trajectories mothers fathers relationship quality couples whose first child born marriage cohabitation carefully consider union transitions years postpartum including subjects variables indicating parents continually married continually cohabiting cohabiting child birth got married cohabiting married child birth subsequently separated anticipated fathers involvement coparenting positively associated parents reports relationship quality mothers fathers especially cohabiting mothers buffering decline mothers fathers relationship quality typically accompanies birth child findings underscore importance father role well child know research also relationship parents fathers encouraged supported take active role parenting educational programs public policy paid paternity leave
allocating tasks processors well known hard problem distributed computing systems due lack practicable exact solutions attracted researchers working heuristic based suboptimal search algorithms recent inclusion multiple objectives minimizing cost maximizing throughput maximizing reliability problem gets even complex efficient approximate method becomes valuable work propose new solution multi objective task allocation problem solution consists designing problem specific neighboring function existing metaheuristic algorithm proven successful quadratic assignment problems neighboring function namely greedy reassignment maximum release provides dynamic mechanism switch preference search exploration exploitation experiments validate quality solutions close optimal proposed method performs significantly better comparing three metaheuristic algorithms neighboring functions common reusable components metaheuristic algorithms also utilized metaheuristic based solutions future elsevier ltd rights reserved
fluid structure interaction fsi analysis full scale hydraulic arresting gear used retard forward motion aircraft landing aircraft carrier deck performed simulations make use recently developed core special purpose fsi techniques problem classes specialized present application recently proposed interactive geometry modeling parametric design platform isogeometric analysis iga directly employed create arresting gear model illustrates natural application iga problem class fluid mechanics fsi simulation results reported terms arresting gear rotor loads blade structural deformation vibration excellent agreement achieved experimental results arresting gear design simulated work elsevier ltd rights reserved
abstractness modality interpersonal communication considerable impact comprehension relevant determining thoughts constituting internal models environment whereas concrete object related information represented mind irrespective language abstract concepts require representation speech consequently modality independent processing abstract information expected investigated neural correlates abstractness abstract concrete modality speech gestures identify abstractness specific supramodal neural network fmri data acquisition participants presented videos actor either speaking sentences abstract social concrete object related content performing meaningful abstract social emblematic concrete object related tool use gestures gestures accompanied foreign language increase comparability conditions frame communication context gesture videos participants performed content judgment task referring person object relatedness utterances behavioral data suggest comparable comprehension contents communicated speech gesture furthermore found common neural processing abstract information independent modality boolean left hemispheric network including left inferior frontal gyrus ifg temporal pole medial frontal cortex modality specific activations found bilateral occipital parietal temporal well right ferior frontal brain regions gesture left anterior temporal regions left angular gyrus processing speech semantics data support idea abstract concepts represented supramodal manner consequently gestures referring abstract concepts processed predominantly left hemispheric language related neural network
background pulled elbow nursemaid elbow common injury young children results sudden pull arm usually adult taller person pulls radius annular ligament resulting subluxation partial dislocation radial head child experiences sudden acute pain loss function affected arm pulled elbow usually treated manual reduction subluxed radial head various manoeuvres applied textbooks recommend supination forearm opposed pronation approaches unclear manoeuvre successful update cochrane review first published objectives objective review compare effectiveness painfulness different methods used manipulate pulled elbow young children search methods searched cochrane bone joint muscle trauma group specialised register cochrane central register controlled trials medline embase cinahl lilacs pedro clinical trial registers reference lists articles date last search july selection criteria randomised quasi randomised controlled clinical trials evaluating manipulative interventions pulled elbow included primary outcome failure first attempt necessitating treatment data collection analysis two review authors independently evaluated trials inclusion included trials independently assessed risk bias extracted data main results one trial children newly included update overall four trials children younger seven years old included four trials compared pronation versus supination one trial high risk selection bias allocation concealed four trials high risk detection bias due lack assessor blinding pronation resulted statistically significantly less failure supination versus risk ratio confidence interval pain perception reported two trials data unavailable pooling studies concluded pronation technique less painful supination technique authors conclusions limited evidence four small low quality trials pronation method might effective less painful supination method manipulating pulled elbow young children recommend high quality randomised trial performed strengthen evidence
background gut microbiome infancy influences immune system maturation may important impact allergic disease risk objective sought determine prenatal early life factors impact gut microbiome relatively large ethnically diverse study population infants age months enrolled vitamin antenatal asthma reduction trial clinical trial vitamin supplementation pregnancy prevent asthma allergies offspring methods performed rrna gene sequencing infants stool samples microbial diversity computed using shannon index factor analysis applied top abundant taxa revealed underlying bacterial coabundance groups first dominated firmicutes lachnospiraceae clostridiales second proteobacteria klebsiella enterobacter third bacteriodetes fourth veillonella scores coabundance groups used outcomes regression models prenatal birth demographic characteristics independent predictors multivariate analysis using microbial community members also conducted results white race ethnicity associated lower diversity higher bacteroidetes coabundance scores section birth associated higher diversity decreased bacteroidetes coabundance scores firmicutes scores higher infants born section breast fed infants lower proportions clostridiales cord blood vitamin linked increased lachnobacterium decreased lactococcus conclusions findings presented suggest race mode delivery breast feeding cord blood vitamin levels associated infant gut microbiome composition possible long term implications immune system modulation asthma allergic disease incidence
asian soybean rust asr caused obligate biotrophic fungus phakopsora pachyrhizi cause losses greater despite economic importance soybean cultivar durable asr resistance addition pachyrhizi genome yet available however availability rust genomes well development sample enrichment strategies bioinformatics tools improved knowledge asr secretome potential effectors context used combination laser capture microdissection lcm rnaseq bioinformatics pipeline identify total pachyrhizi contigs expressed planta predicted secretome proteins predicted secreted proteins characteristics candidate effectors small size cysteine rich contain pfam domains except associated pathogenicity strongly expressed planta comparative analysis predicted secreted proteins present pucciniales species identified new members soybean rust new pucciniales pachyrhizi specific families tribes members families strongly regulated early infection starting initial infection haustorium formation effector candidates selected two families able suppress immunity transient assays localized plant cytoplasm nuclei experiments support bioinformatics predictions show families contain members functions consistent pachyrhizi effectors
objectives elucidate benefits pitfalls risks phytotherapy clinical practice otorhinolaryngology material methods pubmed cochrane databases searched using following keywords phytotherapy phytomedicine herbs otology rhinology laryngology otitis rhinitis laryngitis otorhinolaryngology seventy two articles prospective randomized studies cochrane analyses meta analysis reviews literature devoted clinical studies analyzed articles devoted vitro animal studies biochemical analyses case reports including fewer patients articles dealing honey aromatherapy minerals excluded results per ginkgo biloba indications tinnitus pre sbycusis anosmia following viral rhinitis traditional asian medicine proven benefit sudden deafness laryngeal papillomatosis per mistletoe extracts associated conventional treatment head neck squamous cell carcinoma increase year survival extracts various herbs notably echinacea eucalyptus petasites hybridus pelargonium sidoides rosemary spirulina thyme show superiority placebo rhinosinusitis allergic rhinitis gingko biloba selected vertigo encouraging preliminary results intratumoral injection mistletoe head neck carcinoma acupoint herbal patching allergic rhinitis herb intake screened case certain unexplained symptoms epistaxis headache dizziness signs suggesting allergy phytotherapy interrupted ahead surgery chemotherapy conclusion scientific proof benefit phytotherapy otorhinolaryngology remains established given widespread use reported data knowledge form treatment needs developed elsevier masson sas rights reserved
paper design procedure realization current mode biquadratic transfer functions presented synthesis technique deduced signal flow graph representation using current follower transconductance amplifiers cftas proposed configuration single low impedance input five high impedance outputs comprises three cftas two grounded capacitors passive resistor required circuit realization thus active structure suitable integration
evolution method identification local electric insulation defects windings disconnected electric motors summarized locate local defect paper suggests use resistance calculated based parameters transient discharge preliminary charged cable capacitances locate ground fault electric motor stator winding frequency voltage phases used
congenital hypothyroidism one common causes preventable mental retardation thyroid hormone essential role brain development first years life incidence live births evidence incidence increasing majority newborn babies exhibit obvious clinical signs symptoms age months due either residual thyroid function transplacental passage maternal thyroid hormone common clinical symptoms include lethargy sleepiness poor feeding constipation prolonged jaundice common findings clinical examination include macroglossia large fontanels umbilical hernia hypotonia neonatal screening practiced developed countries last three decades various studies show normal cognitive function attainable early detection treatment review discusses different protocols used screening highlights recent recommendation screening retesting cutoffs thyroid imaging help differentiating underlying etiology either thyroid dysgenesis dyshormonogenesis treatment levothyroxine mcg started immediately diagnosis without delaying imaging purposes frequent vigilant monitoring dose adjustment mandatory infancy childhood achieve normal physical growth neurodevelopment children followed different pediatric specialties including general pediatricians neonatologists developmental pediatricians endocrinologists primary care therefore essential increase awareness monitoring protocols among physicians
fixed geo satellite communications impaired long rtts especially geo possible presence packet losses satellite radio channels moreover satellite receiver mobile short long disruptions due line sight obstructions associated presence shadowing cause performance deterioration paper evaluate impact disruptive channel pepsal tcp splitting pep previously developed authors results obtained emulating satellite link interruptions caused tunnels real railway line highlight advantages tcp splitting architecture enabling adoption optimized version tcp satellite connection satellite specific tuning tcp parameters pepsal offer significant resilience kind satellite impairments
calprotectin heterodimer formed two proteins mainly produced activated monocytes neutrophils circulation inflamed tissues implication calprotectin inflammatory process already demonstrated role pathogenesis diagnosis monitoring rheumatic diseases gained great attention recent years calprotectin stable room temperature candidate biomarker follow disease activity many autoimmune disorders predict response treatment disease relapse evidence number immunomodulators including tnf alpha inhibitors may reduce calprotectin expression potential role target treatment murine models autoimmune disorders since direct indirect blockade proteins results amelioration disease process review biologic functions calprotectin might involved etiology rheumatic disorders also report evidence potential use disease biomarker
paper filtering characteristics two kinds complementary ring resonator add drop filters modeled investigated graphical approach signal flow graph employed analytical derivation optical transfer functions domain filters characteristics complementary circuits including transmittance group delay drop port respect input port simulated present analysis restricted directional couplers characterized two parameters power coupling coefficient power coupling loss explicit expressions phase delay full width half maximum factor finesse also given using appropriate coupling coefficients filtering characteristics optimized elsevier rights reserved
objective main objective pilot study investigate safety administering onabotulinumtoxina towards sphenopalatine ganglion patients intractable chronic migraine open uncontrolled design also collected efficacy data provide indication whether future placebo controlled studies performed method prospective open label uncontrolled study one month baseline performed bilateral injections onabotulinumtoxina total dose toward sphenopalatine ganglion single outpatient session patients intractable migraine follow weeks primary outcome adverse events main efficacy outcome frequency moderate severe headache days month post treatment compared baseline results patients experienced total adverse events majority different types local discomfort face jaw none classified serious intention treat analysis main efficacy outcome statistically significant reduction moderate severe headache days baseline versus month observed days baseline versus days month eight patients experienced least reduction moderate severe headache days compared baseline conclusion result warrants randomised placebo controlled studies establish safety efficacy potential novel treatment chronic migraine
biologic therapies may cause called paradoxical side effects onset exacerbation new symptoms diseases biological treatment effective among psoriatic skin lesions described report case series ten patients either new onset seven cases worsening three cases psoriasis occurring biologic therapy six patients receiving biologic monotherapy four patients combination treatment methotrexate mtx psoriasis remission observed two patients discontinued biologic therapy six patients biologic therapy discontinued complete disappearance partial improvement skin lesions achieved following topic steroid therapy two patients three patients respectively remaining patient psoriasis developed adalimumab monotherapy completely disappeared infliximab mtx combination started potential pathogenetic mechanisms shortly reviewed
performance four geosynthetic clay liners gcls used hydraulic barrier concrete lined sewage treatment lagoons examined based series laboratory tests aimed measuring lateral flow synthetic wastewater interface gcl product thick cast place concrete gcl month period data calculating concrete gcl interface transmissivity theta hydraulic conductivity gcls poured concrete exposed iia synthetic wastewater isothermal conditions iib series wet dry cool heat cycles months four gcls either sodium polymer enhanced sodium bentonite either granular powdered bentonite wastewater head gcl stress concrete sigma kpa gcl granular sodium bentonite gcl head increased sigma kpa value reduced one order magnitude gcl polymer enhanced granular bentonite value similar possibly lower gcl untreated granular bentonite gcl powdered bentonite cover geotextile impregnated bentonite values head respectively reduction amount impregnated powdered bentonite cover geotextile theta lowest gcl concrete exposed wastewater isothermal conditions measured gcl polymer enhanced granular bentonite whereas highest value gcl standard granular bentonite head kpa stress gcl concrete exposed wet dry cycles times gcl exposed wastewater isothermal conditions analytical calculations leakage concrete gcl liners four gcls showed leakage allowable limits specified australian british american standards
paper presents basic background status energy efficient building evaluation standards china abroad introduces main technical contents evaluating index system energy efficient building renovation china summarizes characteristics end evaluating results five evaluated projects using standard compared using evaluation standard green building though similar results obtained comparison indicates standard good scientificalness operability elsevier ltd rights reserved
objective investigate association maternal posttraumatic stress disorder ptsd infant development south african birth cohort method data drakenstein child health study analyzed maternal psychopathology assessed using self report clinicianadministered interviews month infant development using bayley iii scales infant development linear regression analyses explored associations predictor outcome variables results data mothers infants set twins included mothers reported lifetime trauma exposure lifetime prevalence ptsd maternal ptsd significantly associated poorer fine motor adaptive behavior motor development latter remaining significant adjusted site alcohol dependence infant head circumference age score birth conclusion maternal ptsd may associated impaired infant neurodevelopment work low middle income populations may improve early childhood development context
medicinal plants widely used long history exploration pharmacologically active compounds medicinal plants present broad prevalent application examining viral mrna expression gcrv infected ctenopharyngodon idella kidney cik cells treated thirty kinds plant extracts identified magnolia officinalis rehd wils able preferably suppress viral replication studies demonstrated main ingredients magnolia bark namely magnolol honokiol presented protective pharmacological function treated gcrv infected cik cells concentration respectively furthermore reverse transcript quantitative polymerase chain reaction qpcr western blot showed magnolol honokiol efficient restrain replication gcrv cik cells non toxic concentration magnolol honokiol moreover found magnolol honokiol promoted expression immune related genes magnolol obviously significantly increased expression interferon ifn regulatory factor irf rather irf gcrv infected cells leading activation type ifn ifn simultaneously magnolol drastically facilitated expression interleukin beta failed induce molecules nuclear factor omicron pathways differently honokiol strikingly motivated expression beta also tumor necrosis factor alpha tnf alpha kappa interestingly though honokiol motivated expression ifn beta promoter stimulator ips irf irf failed regulate expression ifn indicating honokiol enhanced host innate antiviral response gcrv infection via kappa pathways collectively present study revealed magnolol honokiol facilitated expression innate immune related genes strengthen innate immune signaling responses resist gcrv infection contributed understanding mechanisms small molecule drugs possessed antiviral activities addition results lay foundation development broad spectrum antiviral compounds aquaculture industry elsevier ltd rights reserved
paper presents design experimental validation new model free data driven iterative reference input tuning irit algorithm solves reference trajectory tracking problem optimization problem control signal saturation constraints control signal rate constraints irit algorithm design employs experiment based stochastic search algorithm use advantages iterative learning control experimental results validate irit algorithm applied non linear aerodynamic position control system results prove irit algorithm offers significant control system performance improvement iterations experiments conducted real world process model free parameter tuning
background aims maltreatment childhood adolescence risk factor substance use disorders suds adulthood association rarely investigated light emotion dysregulation fill gap study examines emotion dysregulation suds among adults history early maltreatment methods comparison emotion dysregulation adults history early abuse neglect developed either sud mental disorder mediation model association severity early maltreatment suds tested participants completed research diagnostic interviews psychopathology difficulties emotion regulation scale childhood trauma questionnaire results using hierarchical regression techniques mediational analyses controlling age gender possible provide evidence mediating role emotion dysregulation early emotional physical maltreatment later suds conclusions emotion dysregulation potential mechanism underlying relationship early emotional physical maltreatment development suds light findings focusing early training adaptive emotion regulation strategies childhood maltreatment might considerable relevance prevent development suds karger basel
human progesterone receptor plays key role reproductive function women antagonists numerous applications female health care including regular emergency contraception treatment hormone related pathological conditions breast cancer endometriosis leiomyoma main factor limiting long term administration fact cross bind oxo steroid receptors ulipristal acetate upa highly potent antagonist recently come onto market much selective oxo steroid receptors androgen glucocorticoid mineralocorticoid receptors remarkably displays lower inactivating potency adopted structural approach characterizing binding upa oxo steroid receptors molecular level solved ray crystal structure ligand binding domain lbd human complexed upa peptide transcriptional corepressor smrt used ray crystal structure antagonist conformation dock upa within ligand binding cavity finally generated three dimensional models lbd androgen mineralocorticoid receptors antagonist conformation docked upa within comparing structures revealed network stabilizing contacts upa aryl group lbd responsible high antagonist potency also showed inability upa contact gln explains lower potency inactivating finally found binding pockets small accommodate upa allowed propose extremely low sensitivity upa due inappropriate interactions substituent findings open new avenues designing new antagonist compounds displaying greater selectivity elsevier ltd rights reserved
consolidation soil surcharge loading prefabricated vertical drains effective ground improvement technique saturated cohesive soils marine clay four types band shaped drains made single layer woven non woven jute geotextile filter fabric wrapped around core coir ropes mats designated natural drains newly developed fabricated laboratory marine clay confined discharge capacity large scale consolidation tests conducted natural drains commercially available polymer based drains effect compressive stress discharge capacity natural drains studied compared polymer based drains consolidation performance drains remoulded marine clay studied consolidation tests marine clay without drains observed rate settlement marine clay almost identical marine clay samples drains drains accelerated consolidation marine clay numerical simulations experimental consolidation tests carried using plaxis magnitude rate settlement obtained numerical consolidation analysis matched closely experimental results concluded eco friendly easily fabricated natural drains help accelerating consolidation marine clay
background benign prostatic hyperplasia bph lower urinary tract symptoms luts conditions extremely prevalent aging male although androgens involved prostate growth developmental age role pathogenesis bph luts debated recent data indicate low testosterone high estradiol favor disease progression addition role determinants metabolic syndrome prostate inflammation emerging aim reviewed evidence regarding pathogenesis bph luts particular attention metabolic influence materials methods review published evidence performed using medline results available evidence shows three hit hypothesis drawn overt even subclinical bacterial viral infection could induce prostatic inflammation first hit could autosustained exacerbated presence altered metabolism particular hypercholesterolemia second hit hypogonadism hyperestrogenism could act third hit favoring maintenance inflammatory state combined action three hits even two may result overexpression toll like receptors tlrs transformation prostatic cells antigen presenting cells activation resident human prostate associated lymphoid tissue ending overproduction growth factors turn induce prostate remodeling prostate enlargement mechanical obstruction along direct action unfavorable metabolic hormonal milieu bladder neck helps generating luts conclusion inflammation dyslipidemia altered sex steroid milieu mutually concur determining bph luts
universal aptameric system based taking advantage double stranded dna perylene diimide dsdna pdi signal probe developed multiplexed detection small molecules aptamers single stranded dna rna oligonucleotides selected vitro process known systematic evolution ligands exponential enrichment work synthesized new kind pdi reported aggregated pdi could quench double stranded dna dsdna labeled fluorophores high quenching efficiency quenching efficiencies fluorescence fam tamra could reach respectively broad spectrum quencher adopted construct multicolor biosensor via label free approach structure switching triggered enzymatic recycling amplification employed signal amplification high quenching efficiency combined autocatalytic target recycling amplification afforded biosensor high sensitivity towards small analytes targets changing corresponding aptamer achieve goal quencher interfere catalytic activity nuclease biosensor could manipulated similar sensitivity matter pre addition post addition manner moreover simultaneous multiplexed analysis several small molecules homogeneous solution achieved demonstrating potential application rapid screening multiple biotargets
morpho butterfly famous typical structural color increasingly attracted interest scholars wide variety research fields herein found color morpho menelaus butterfly wings structure based also viewing angle dependent firstly discoloration effect typical butterfly confirmed series experiments general form arrangements geometrical dimensions scales observed using stereomicroscope scanning electron microscopy also used examine two dimensional morphologies structures single scale afterwards one model optimized three dimensional profile structure described using pro engineer software associate model analyzed reconstruct process incident light model surface finally mechanism angle dependent discoloration effect analyzed theoretical calculation optical simulation different light propagation paths length incident light different angles caused destructive constructive interference light reflected different layers different spectra reflected light make wings appear different structural colors thereby endowing angle dependent discoloration effect consistency calculation simulation results confirms structures possess excellent angle dependent discoloration effect functional biomimetic structure would great scientific interest could also great impact wide range applications reflective displays credit card security military stealth technology
cardiovascular disease leading cause death women advanced age affected decade later compared men cardiovascular risk factors women properly investigated treated events frequently lethal menopause type diabetes substantially increase cardiovascular risk female sex promoting modifications lipid metabolism circulating lipoproteins lipoprotein subfractions suffer shift menopause towards atherogenic lipid profile consisted hypertriglyceridemia lower levels total high density lipoprotein hdl subfraction hdl also higher levels hdl small low density lipoprotein particles review discusses impact diabetes menopause lipid profile challenges lipoprotein subfractions determination potential contribution cardiovascular risk assessment women still unclear whether lipoprotein subfraction changes major driver cardiometabolic risk modifications predominant prospective trials larger samples methodological standardizations pharmacological approaches needed clarify role lipoprotein subfractions determination cardiovascular risk prediction intervention planning postmenopausal women without
machine learning models site metabolism som prediction offer ability identify metabolic soft spots low molecular weight drug molecules low computational cost enable data based reactivity prediction som prediction atom classification problem successful construction machine learning models requires atom representations capture reactivity determining features potential reaction site developed descriptor scheme characterizes atom steric electronic environment relative location molecular structure partial charge distributions obtained fast quantum mechanical calculations successfully trained machine learning classifiers curated cytochrome metabolism data models based new atom descriptors showed sustained accuracy retrospective analyses metabolism optimization campaigns lead optimization projects bayer pharmaceuticals results obtained demonstrate practicality quantum chemistry supported machine learning models hit lead optimization
asthma become leading cause childhood disability school absenteeism united states asthma manageable chronic disease cost management rise especially asthma related emergency department visits cost five times primary care visits nonetheless costs asthma management significantly decreased using effective management strategies via social network analyses finding ways reduce asthma triggers may cause visits study social network analysis model developed evaluates impact asthma management interventions number visits asthmatic children simulation results show implementation early symptom identification strategy asthmatic children parents decrease average number annual visits asthmatic crisis visits visits per patients diagnosed asthma addition simulation results reveal implementation asthma awareness programme schools targeting teachers staff members reduces annual visits asthmatic crises per patients diagnosed disorder visits per year asthma awareness campaign school children would lead drop annual visits asthmatic crisis per patients diagnosed disorder visits per year use public asthma awareness campaign leads change annual visits asthmatic crisis per patients diagnosed disorder visits visits per year
two new zinc chlorophenylacetate complexes chchcoo phen chchcooh chchcoo bipy chchcooh nitrogen donor ligands phenanthroline phen bipyridine bipy synthesized characterized spectroscopy single crystal diffraction distorted octahedral geometry confirmed complexes compounds studied thermal stabilities using dta methods different heating rates min found complexes show trend stabilities thermally degrade two stages apparent activation energies step specific conversions determined using doyle ozawa calculation method according ictac recommendations calculated average activation energies found mol first second stages degradation respectively similarly corresponding values two stage degradation found mol determining enthalpy value activation revealed exergonic nature thermal degradation
potential power augmented reality makes possible change semiotic meaning real space strongly influence human attitude behavior achieving better lifestyle typical approaches simply integrate computer generated virtual images real space spatial aspect approach limits potential power objects real space enhanced contrast virtual reality technologies make possible create new fictional realistic virtual space using models real persons landscapes paper propose new concept named alternative reality used building new type ambient intelligence experiences alternative reality makes possible connect real space virtual space temporally integrate two spaces seamlessly virtual space consists real landscapes persons fictional ones change semiotic meaning real space strongly influence human attitude behavior however virtual space reflect events actually happened real space means may possible enhance real space showing fictional events among real events demonstrating alternative reality concept developed case study named fictional future virtual space constructed fictional events performed real persons real landscapes conducted user study case study show feasibility alternative reality concept user study shows alternative reality augments real space effectively user still experiences virtual space real space
study objective examine parent child relationships parental control parental attitudes towards sex related pregnancy outcomes among adolescent mothers design prospective cohort study parental report relationship satisfaction disapproval adolescent sex discussion around sexual health sexual communication attitudes adolescent report relationship satisfaction parental control parental disapproval sex examined predictors self reported birth outcomes weighted multivariable linear regression models run incorporating interactions race setting united states participants females participated waves national longitudinal study adolescent health add health nationally representative sample students enrolled grades followed main outcome measures birthweight gestational age results black adolescents better parent child relationship associated higher birthweight gestational age weeks higher parental disapproval sex adjusted beta associated higher birthweight non black adolescents moderate amount discussion birth control associated higher birthweight lower child perceived parental disapproval sex associated higher birthweight gestational age weeks higher parental control associated reduced likelihood smoking pregnancy greater likelihood early prenatal care conclusion parent child relationships attitudes sex affect outcomes pregnant adolescents
background individuals multiple sclerosis experience clinical course highly variable daily fluctuations symptoms significantly affecting functional ability quality life yet understanding symptoms vary associate physical psychological health unclear objective purpose study explore variability patterns time bound relationships across symptoms affect physical activity individuals methods study employed multivariate replicated single subject repeated measures mrsrm design involved four individuals mood fatigue pain balance confidence losses balance measured daily days self report physical activity also measured daily time period via accelerometry dynamic factor analysis dfa used determine dimensionality lagged relationships across variables results person specific models revealed considerable time dependent variation patterns well pattern variation across subjects results also offered insight distinct variability structures varying levels disability conclusion modeling person level variability may beneficial addressing heterogeneity experiences individuals understanding temporal dynamic interrelationships among perceived symptoms affect health outcomes group elsevier inc rights reserved
work smart optical rotary sensor fly wire fbw control system airplanes proposed different parts sensor rotary encoder shaft optical systems electrical circuits micro controller packed single housing replacing analog sensors currently used fbw control system smart sensors results integrated lighter aircraft
multiple myeloma causes osteolytic lesions detected fluorodeoxyglucose positron emission tomography computed tomography fdg pet prospectively involve newly diagnosed take pet scan scheduled treatment time figure fdg uptake lesion measured suvmax mmax patients took bortezomib based chemotherapy induction received asct maintenance clinical features analyzed pet image changes relationships treatment response fdg uptakes changes found osteolytic lesions uptakes higher fdg healthy volunteers trend obvious extramedullary lesions compared ray pet sensitive discoering bone well extramedullary lesions newly diagnosed several adverse clinical factors related high fdg uptakes bone lesions bone lesion fdg uptakes mutation hypodiploidy complex karyotype also higher without changes treatment response pet showed higher sensitivity detecting tumor residual disease immunofixation electrophoresis relapse prediction might show false positive disease recurrences imaging changes might influenced infections hemoglobulin levels conclusion pet sensitive discovering meduallary extrameduallary lesions fdg uptake lesions related clinical indictors biological features plasma cells evaluating treatment response survival pet showed superiority predicting relapse refractory may show false positive results
study objectives several organizations provided recommendations ensure high school starts sooner however although plausible biological reasons support recommendations published recommendations based largely expert opinion observational studies sought perform critical review published evidence regarding effect high school start times sleep relevant outcomes methods performed broad literature search identify candidate publications inclusion review focused studies offering direct comparison sleep time academic physical performance behavioral health measures motor vehicular accidents high school students possible outcomes combined meta analysis results application study criteria studies suitable review eight studies amenable meta analysis outcomes found later school start times particularly compared start times min earlier associated longer weekday sleep durations lower weekday weekend sleep duration differences reduced vehicular accident rates reduced subjective daytime sleepiness improvement academic performance behavioral issues less established conclusions literature regarding effect school start time delays important aspects high school life suggests salutary effects often evidence indirect imprecise derived cohorts convenience making overall quality evidence weak weak review highlights need higher quality data upon base important complex public health decisions
temporal patterns water quality variation khlong tapao river basin thailand analyzed stations along river basin research objective study correlation water quality temporal variation climatic hydrology years using multivariate statistical analysis analyze water quality dataset parameters water temperature turbidity conductivity dissolved oxygen biochemical oxygen demand bod total coliform bacteria tcb fecal coliform bacteria fcb ammonia nitrogen results show seasonal change affected water quality variation climatic hydrologic parameters climatic hydrologic water quality relationship maximum climatic temperature positive negative temporal hydrologic water quality relationship precipitation positive negative water inflow positive negative water outflow positive negative water level positive bod tcb spatial temporal hydrologic water quality relationship river cross section positive negative assessment multiple linear regression equations explain water quality variations climatic hydrologic factors therefore water quality management consideration climatic hydrologic variation provide basal information developing improved water pollution control procedures khlong tapao river basin
objectives examined extent different aspects parenting able moderate association spending time unstructured socializing urban areas high disorder adolescent delinquency methods used detailed data time use disorder neighborhoods parenting delinquency among adolescents aged study peers activities neighborhoods two wave longitudinal study interval two years measurements longitudinal multilevel analyses used examine interactions effects parenting aspects mean differences well individual changes time spent unstructured socializing areas high disorder results find person level interaction effects parenting time spent criminogenic settings cross level analyses however indicated levels parental monitoring well quality parent adolescent relationship mitigated effects changes time spent criminogenic settings conclusions whether increases time spent criminogenic settings related increases delinquency seems conditional level parental monitoring quality parent adolescent relationship aspects parenting sufficient changes time spent criminogenic settings necessarily detrimental
accurate thermodynamic parameters improve rna structure predictions thus accelerate understanding rna function identification rna drug binding sites many viral rna structures internal ribosome entry sites internal loops bulges potential drug target sites current models used predict internal loops biased toward small symmetric purine loops thus poorly predict asymmetric pyrimidine rich loops nucleotides occur frequently viral rna article presents new thermodynamic data pyrimidine loops many form protonated base pairs uracil protonated cytosine base pairs stabilize asymmetric internal loops accurate prediction rules presented account thermodynamic measurements rna asymmetric internal loops new loop initiation terms loops presented follow previous assumptions increasing asymmetry destabilizes loops since last update new loops asymmetry sizes greater measured new measurements significantly deepen diversify thermodynamic database rna results help better predict internal loops larger pyrimidine rich occur within viral structures internal ribosome entry sites
paper deals charging stations electric cars containing accumulation electrical energy support usually charging stations called active charging stations parts modern electrical grid known smart grids micro grids paper also contains brief summary current knowledge structures service electricity distribution networks analysis electric car industry growth potential impact electrical network
control wirelesshart recent years become interestingly attractive researchers academia industry offers reduced cost less complexity however cost increased delays uncertainties system caused wirelesshart transmitters use conventional pid controllers delayed network also leads instability paper smith predictor technique adequately handle dead time predicting delay free model process employed comparison simulation results plants considered showed performance smith predictor better optimized pid controllers terms percentage overshoot settling time error
preconditioned navier stokes method developed multiphase flow application water entry problem moving bodies method employs dual time preconditioned technique multiblock parallel computing improve computational productivity novel generalized pseudo time terms added multiphase equations taking advantage two previous suggestions reported literature solver formulated moving curvilinear coordinate system multiphase flow including water vapor air fluids order handle motion object three dimensional water entry problems six degrees freedom dof rigid body motion model moving chimera grid scheme dynamically integrated solver chimera domain decomposition scheme uses overlapping embedded moving grid approach facilitate flow simulation arbitrary translationally rotationally complex geometries among various computational blocks domain communication module fully parallel ideally suited handling moving body problems demonstrate capacities method several sets example computations performed presented paper elsevier ltd rights reserved
psychopathy personality disorder characterized callous antisocial behavior criminal recidivism examine whether psychopathy associated alterations functional connectivity three large scale cortical networks using fmri adult male prison inmates computed resting state functional connectivity using seeds default mode network frontoparietal network cingulo opercular network determine specificity findings cortical networks also calculated functional connectivity using seeds two comparison primary sensory networks visual auditory networks regression analyses related network connectivity overall psychopathy scores subscores factors facets psychopathy factor interpersonal affective traits factor lifestyle antisocial traits facet interpersonal facet affective facet lifestyle facet antisocial overall psychopathy severity associated reduced functional connectivity lateral parietal cortex dorsal anterior cingulate cortex two factor scores exhibited contrasting relationships functional connectivity factor scores associated reduced functional connectivity three cortical networks whereas factor scores associated heightened connectivity networks dissociation evident particularly functional connectivity anterior insula dorsal anterior cingulate cortex facet scores also demonstrated distinct patterns connectivity found associations psychopathy scores functional connectivity within visual auditory networks findings provide novel evidence neural correlates psychopathy suggest connectivity cortical association hubs dorsal anterior cingulate cortex may neurobiological marker disorder
paper new type hybrid reluctance actuator presented linear hybrid reluctance actuator two phase double sided actuator stator composed four normalized cores coil wrapped around yoke connecting two arms core two coils wound arms permanent magnet placed near air gap contact arms mover comprised rectangular poles without connecting iron pieces mechanically joined non magnetic mounting parts magnets arranged flux parallel flux created coils energized fluxes added total reinforced flux links stator mover currents flow coils flux crosses air gap flux magnets closed back iron supports analysis simulation motor using finite element matlab simulink carried finally comparison type actuator respect linear reluctance stepper motor size shown
introduction investigated child outcomes mothers perspectives following technology based intervention sessions aimed improving children social play skills method participants multiple case study included five children attention deficit hyperactivity disorder mothers five typically developing playmates completed parent delivered play based intervention months previously initial intervention included use technology based interactive dvd home clinic based sessions involving video modelling study children received two additional technology based clinic sessions involving video modelling children social play skills measured pre post intervention using test playfulness trends scores descriptively analysed case mothers perspectives explored semi structured interviews data descriptively analysed group case results two children attention deficit hyperactivity disorder showed increase social play skills three decrease skills playmates three showed consistent social play skills one increase one decrease qualitative findings suggest parents felt better able support child parents also suggested next steps intervention necessary child continued develop conclusion additional intervention support using technology initial intervention may need adapted different developmental stages use across different contexts
background oral hygiene patients mental illness important concern psychiatric care necessary increase level self care among patients study administered oral care questionnaire people mental illness japan compared answers baseline week months participated educational program methods questionnaire distributed patients included questions age education income meal snacks number teeth frequency tooth brushing items educational program developed purposes improving self care results program proportion male patients mental illness years significantly higher among patients brush teeth bed addition patients primary care dentists significantly higher proportion male patients compared female patients undergo routine dental checkups per year educational program resulted improvement use fluoride toothpaste baseline months intervention daily use interdental brushes floss significantly different months intervention conclusions male long term inpatients need oral hygiene instructions educational program showed effects using oral hygiene tools future studies include control group measure impact educational program
background aims somatization may influence persistence severity symptoms gastrointestinal diseases studies suggest somatization associated chronic uninvestigated dyspepsia cud however association unclear aimed determine association profiles somatic complaints cud symptoms methods cross sectional study conducted iranian adults somatic complaints assessed using comprehensive items questionnaire patients cud identified rome iii diagnostic criteria profiles somatic complaints derived factor analysis logistic regression analysis used assess relationship extracted profiles cud symptoms results cud bothersome postprandial fullness early satiation epigastric pain burning identified study population frequency somatic complaints significantly higher patients cud compared controls frequent severe fatigue profiles somatic complaints extracted domains including psychological gastrointestinal neuro skeletal pharyngeal respiratory psychological gastrointestinal neuro skeletal pharyngeal respiratory profiles significantly associated greater odds cud conclusions cud symptoms strongly associated higher levels somatic complaints related extracted profiles perhaps explains difficult treat however prospective investigations required confirm associations
computer technology advanced profoundly application seems limit equipped programming research team created programs could used practically field chemistry purpose paper making useful tools science using analytic tools based computer programming find additional evidence supports theory suport vector machine also known acronym svm used frequently genetic analysis find certain patterns dna sequence paper deals pattern similarity rrna mitochondria alphaproteobacteria believed ancestor mitochondria theory also known endosymbiotic theory variety evidences accepted authentic pattern similarity two organisms dna sequence result paper would consolidate evolutionary endosymbiosis
errors folate metabolism may play role pathology autism spectrum disorders increased vulnerability oxidative stress report case methylfolate supplementation improved symptoms aggression disruptive behavior child autism tested positive ctt allele methyltetrahydrofolate reductase enzyme gene knowledge first report methylfolate administration situation controlled studies methylfolate population warranted copyright wolters kluwer health inc rights reserved
paper alternative method based artificial neural networks presented determination load current harmonic components single phase electric power system first six harmonic components calculated current waveforms controller single phase diode bridge rectifier common loads industrial commercial residential applications influences nonlinear loads power quality issues also characterized proposed method compared truncated fft simulation experimental results presented order validate proposed approach
evaluation six maize varieties four different water harvesting tillage technologies undertaken aim determining effect performance maize genotypes effectiveness improving nutrient water use efficiency work carried mariakani site one kari centres representing arid semi arid lands coastal kenya long rains short rains seasons respectively results indicate rainwater harvesting critical season wetter normal arid semi arid environments demonstrated high yields recorded maize varieties pwani hybrid coast composite maize ccm local check mdzihana usually require relatively high rainfall amounts order produce better yields despite excellent performance ccm mdzihana maize varieties recommended semi arid areas since high yields realized normal rainfall need research identify maize varieties would appropriate areas normally receive low rainfall
railroad tracks need periodically inspected monitored ensure safe transportation automated track inspection using computer vision pattern recognition methods recently shown potential improve safety allowing frequent inspections reducing human errors achieving full automation still challenging due number different possible failure modes well broad range image variations potentially trigger false alarms addition number defective components small many training examples available machine learn robust anomaly detector paper show detection performance improved combining multiple detectors within multitask learning framework show approach results improved accuracy detecting defects railway ties fasteners
aim paper showcase significant diagnostic value hesitation wounds terms forensic psychiatric medicolegal interest number studies reviewed update summarize relevant literature incidence distribution character function hesitation wounds well sociodemographic variables psychopathology inducers study also investigates importance forensic criterion distinction suicide homicide well psychiatric diagnostic tool suicide prevention addition paper reports two new cases results conclude equal incidence different distribution hesitation wounds genders furthermore low dispersion hesitation wounds contrasts high dispersion defense wounds inducers psychopathology lies principally axis disorders finally comprehensive analysis non suicidal self injury role self wounding suicide prevention
mesh saliency introduced joined community computer graphics ten years ago benefit various applications instance mesh reduction mesh segmentation self similarity matching scan integration volume rendering printing etc saliency detection successfully applied image processing pattern recognition study world perceptually intelligible robots contrast color images coherence videos geometric signals defined two dimensional manifolds whose discrete representation irregular leading differences nature difficulties solution mesh saliency tackle challenge last decade witnessed significant advances mesh saliency detection however survey recent advances mesh saliency detection well applications yet exist date paper provides first comprehensive reference source shape context based mesh saliency researchers wide range domains including limited computer graphics vision reviews main contributions advantages drawbacks applications known mesh saliency detection methods discusses current trends outlook future study elsevier ltd rights reserved
addressing early phase first episode psychosis focus critical period development schizophrenia treatment success vulnerable period development schizophrenia sets course future long term development illness partial remission role functioning indicates need optimization cost benefit ratio antipsychotic treatment recent atypicals newer formulations also need supplement disorder specific problem specific phase specific cognitive behavioral interventions within individualized approach focuses developmental tasks evaluative dimension self concept preventing neurotoxic relapse well partial remission schizophrenia enhancing role functioning education work social integration important goals early interventions early phase course schizophrenia
generalized schrodinger equation containing correction terms classical kinetic energy derived complex vector space considering extended particle structure stochastic electrodynamics spin correction terms obtained considering internal complex structure particle consequence stochastic average particle oscillations zeropoint field hence generalised schrodinger equation may called stochastic schrodinger equation found second order correction terms similar corresponding relativistic corrections higher order correction terms neglected stochastic schrodinger equation reduces normal schrodinger equation found schrodinger equation contains internal structure disguise revealed form internal kinetic energy internal kinetic energy found equal quantum potential obtained madelung fluid theory bohm statistical theory rest frame particle stochastic schrodinger equation reduces dirac type equation lorentz boost gives dirac equation finally relativistic klein gordon equation derived squaring stochastic schrodinger equation theory elucidates logical understanding classical approach quantum mechanical foundations
testosterone shown organize brain modulate cognitive functions currently unknown whether mental rotation also associated prenatal testosterone exposure testosterone related genetic polymorphisms aim study analyze associations mental rotation performance actual testosterone levels prenatal testosterone level expressed ratio androgen receptor cag repeat polymorphism intellectually gifted boys one hundred forty seven boys aged years enrolled saliva samples collected used elisa actual levels salivary testosterone finger length ratio indicator prenatal testosterone measured hands averaged amthauer mental rotation test used assessment spatial ability cag repeat polymorphism androgen receptor gene analyzed using pcr capillary electrophoresis linear regression revealed finger length ratio number cag repeats androgen receptor gene associated mental rotation actual levels testosterone correlate significantly mental rotation multivariate analysis covariance revealed adjustment age confounding variable effect genetic polymorphism significant results line previous genetic analysis intellectually gifted boys showing importance cag repeat polymorphism androgen receptor gene details interactions androgen signaling testosterone levels metabolism especially prenatal development brain function remain elucidated elsevier ltd rights reserved
two fundamental dimensions underlie person perception warmth competence conducted three experiments investigate positive negative emphasis one dimensions warmth competence affects perception complementary dimension voting intentions influenced emphases results show politician described positively one two dimensions people assess complementary dimension negatively addition negative emphasis one two dimensions also leads negative assessment complementary dimension furthermore explore one dimensional person descriptions affect assessment speakers uttering politicians describe opponents negative terms also evaluated negatively contrary politicians judge others positive terms necessarily evaluated positively
introduction study sought determine distribution gaba receptors gaba brain duchenne muscular dystrophy dmd patients ascertain distribution pattern correlates cognitive dysfunction methods fourteen dmd patients young adult years old older adult years old groups age matched normal volunteers participated gaba distribution assessed using imz spect neuropsychological assessments performed using different test batteries wais iii wms wisconsin card sorting test wcst results dmd patients showed significant decline imz uptake prefrontal cortex although differences detected wais iii wms wcst scores dmd patients significantly lower normal volunteers abnormalities pronounced older adult patients conclusion findings demonstrate dmd accompanied reduction prefrontal cortex distribution gaba
repeated intermittent exposure cocaine results neurochemical sensitization dopamine transmission within nucleus accumbens nac indeed excitability neurons ventral tegmental area vta enhanced within hours initial psychostimulant exposure however known accompanied comparably rapid change ability cocaine increase extracellular concentrations ventral striatum address question used fast scan cyclic voltammetry fscv awake behaving rats measure responses nac shell following initial intravenous cocaine injection later injections quickly elevated levels nac shell second cocaine infusion produced greater effect first indicating sensitization suggests single injection cocaine induces sensitization related plasticity rapidly within mesolimbic system elsevier rights reserved
osteoporosis periodontal disease linked altered receptor activator nuclear factor ligand osteoprotegerin ratio rankl opg medical treatment bisphosphonate may help control molecules effect clinical findings gingival crevicular fluid gcf values rankl opg using enzyme linked immunosorbent assays evaluated postmenopausal women patients chronic periodontitis osteoporosis group systemically healthy patients chronic periodontitis group periodontally healthy patients osteoporosis group systemically periodontally healthy individuals group recordings repeated end months groups baseline groups exhibited lowest opg values use may effective preventing periodontal breakdown controlling levels markers osteoporosis adjunct periodontal treatment
aims objectivesto understand taxi drivers successful experiences quitting betel nut chewing backgroundprevious studies verified betel nut chewing significantly increases risk oral cancer taiwan taxi drivers work approximately hours per day choose chew betel nuts invigorating qualities enable work hours receive income designa qualitative research design used methodsthis study used grounded theory method purposive sampling perform depth interviews male taxi drivers successfully quit betel nut chewing six months resultsthe interviewed participants taxi drivers aged chewed betel nuts average years constant comparative analysis interviews revealed six categories namely first experience chewing betel nuts part work life perceiving impact betel nuts trying change acting quit betel nut chewing starting new life conclusionsduring cessation process taxi drivers tended affected addiction chewing betel nuts temptation friends invitations chew betel nuts however recognition physical effects betel nut chewing sense responsibility commitment family critical factors affecting determination quit betel nut chewing willpower chew betel nuts source motivation exercise self control also contributed success relevance clinical practicehealthcare personnel understand experiences perceptions betel nut chewers strengthen understanding effects betel nut chewing physical health cessation period support self efficacy quitting behaviours assistance significant others
paper presents neural network based vision inspection system interfaced robot detect report lead defects line vision system consists custom software contains neural network database ics inspected pcb vision system uses gray scale images single layer neural network three outputs based defect criteria different inspection area thus input vector varies ics networks trained matlab bayesian regularization module performance networks investigated found based defect criteria system implemented tested several electronic products using proe opengl software platforms balderas bose automated robotic inspection system electronic manufacturing mse thesis manufacturing engineering department pan american edinbarough amieva experimental study robotics vision inspection electronic components thesis engineering technology department brownsville elsevier rights reserved
purpose intention research paper shed light key factors influencing human resource management hrm performance first tier managers ftms vital importance holistic strategic framework regard design methodology approach research paper uses date historical approach additionally draws detailed case study evidence aerospace manufacturing engineering company via manually electronically analysed depth semi structured interview company documentation findings case study findings reveal ftm hrm performance greatly influenced group four key factors interrelationships research limitations implications literature survey mainly industry specific manufacturing sample restricted one sector aerospace well one case study organisation furthermore views ftms staff directly represented originality value ftms hrm role shows signs abating addition questions regarding performance role increasingly emerged become evident organisations continued expand ftms role devolving greater hrm responsibilities performance role demonstrates many ftms ill equipped perform hrm duties required standard however vital importance holistic strategic framework encompasses four key factors influencing performance performance role acknowledged present research paper gives empirical example case study therefore provides springboard address weakness literature
recent years response higher construction industry standards project design delivery budget time safety constraints technological advances dramatically changed design construction information represented managed prepare students respond new industry demands approaches teaching dynamic construction planning management practices changing result simulation games gaining interest approach providing students learning experiences better aligned complex problems areas construction bidding planning management however use simulation games teaching construction shows promising results remains sporadic due high development costs implementation challenges uncertainty effectiveness learning tools address gap developed evaluated free open source construction management game virtual construction simulator vcs involves teaching holistic decision making process planning managing construction projects paper discusses learning objectives guided vcs development implementation assessment concludes findings recommendations broader implementation future research
variable coefficient nonisospectral modified kadomtsev petviashvili equation two painlev branches investigated paper generalized singular manifold method couple lax pairs equation constructed account relationship manifolds eigenfunctions meanwhile utilizing aforementioned lax pairs binary darboux transformation equation presented
objectiveswe evaluated safety outcome allo hscts myelofibrosis methodsa total patients primary secondary aged transplanted hla matched related unrelated donors analyzed conditioning reduced myeloablative one patient atg used sources stem cells follows peripheral blood bone marrow resultsprognostic factors adversely affected overall survival multivariate analysis follows recipient age unrelated donor post transplant transfusion dependence adversely affected univariate analysis dependence either rbcs platelets either jakvf positive patients evaluated post transplant eradicated decreased acute gvhd iii developed extensive chronic gvhd patients relapse four patients treated second allo hsct spleen decreased evaluated patients fibrotic changes improved disappeared evaluated patients conclusionsallo hsct may prolong survival provide disease regression improve quality life especially patients transplanted matched related donors achieving transfusion independence post transplant indicates favorable outcome
paper describes receiver self contained adaptive equalization sampling point control using chip stochastic sigma tracking eye opening monitor sseom proposed sseom accurately detects bit error rate ber related eye contour efficiently without use external microcontroller sseom determines ber optimal sampling point equalizer coefficients basis pattern filtered eye diagrams also features background adaptation scheme robust long term operation tracking temperature variations device aging proposed sseom integrated receiver designed compensate channel loss nyquist rate using continuous time linear equalizer ctle one tap decision feedback equalizer dfe together one tap pre emphasis transmitter time required complete adaptation total power consumption respectively proposed receiver fabricated cmos
report first application graphics processing units gpus accelerated computing technology improve performance numerical methods used optical characterization evaporating microdroplets single microdroplets various liquids different volatility molecular weight glycerine glycols water etc well mixtures liquids diverse suspensions evaporate inside electrodynamic trap chosen temperature composition atmosphere series scattering patterns recorded evaporating microdroplets processed fitting complete mie theory predictions gradientless lookup table method showed computations gpus effectively applied inverse scattering problems particular technique accelerated calculations mie scattering theory single core processor matlab environment times almost times comparing corresponding code language additionally overcame problems time consuming data post processing parameters particularly refractive index investigated liquid uncertain program allows track parameters characterizing evaporating droplet nearly simultaneously progress evaporation
multidirectional multiscroll chaotic attractors generated second generation current conveyor ccii investigated fourth order fifth order grid multiscroll chaotic system presented designing staircase function shifted voltage sign functions high order jerk system using cciis chaotic circuit designed implemented generate scroll chaotic attractors respectively via switching control compared voltage operational amplifier based circuit proposed circuit better performance terms circuit structure bandwidth numerical simulations experimental results accordant
breast cancer common malignancy women worldwide ovarian cancer lethal gynecological malignancy women carrying brca mutation high lifetime risk developing breast ovarian cancer effective risk reducing strategy brca mutated women prophylactic surgery bilateral mastectomy bilateral salpingo oophorectomy however many women reluctant undergo prophylactic surgeries due consequent mutilated body perception unfulfilled family planning precocious menopause patients effective screening strategy available breast cancer consists close radiological exams significant burden health system significant distress patients biomarkers shown effectively detect breast ovarian cancer early stage micrornas mirnas key regulatory molecules operating post transcriptional regulation gene expression aberrant expression mirnas documented several pathological conditions including solid tumors suggesting involvement tumorigenesis mirnas detected blood urine could used biomarkers solid tumors encouraging results emerging gynecological malignancy well suggest different pattern expression mirnas biological fluids breast ovarian cancer patients compared healthy control aim study highlight role urinary mirnas specifically associated cancer investigate role early diagnosis determining prognosis breast ovarian cancer
background hereditary angioedema hae genetic disorder clinically characterized recurrent attacks subcutaneous mucosal swelling alpha alkylated androgens used prophylactically reduce hae severity many questions efficacy tolerability objective objective study investigate tolerability effectiveness therapy large cohort patients hae methods performed retrospective cross sectional study subjects hae utilizing one time anonymous webbased survey based initial questionnaire patients routed one following questionnaires currently using previously used discontinued never used results statistical analysis revealed androgens decreased attack frequency severity previous users current users substantial variability effectiveness observed users discontinued reported significantly lesser benefit dose effect seen beneficial effect however almost users reported frequent side effects dose related often severe conclusions therapy usually effective treatment hae although substantial fraction patients hae achieve adequate benefit contrast side effects seen almost subjects take medicines used recommended lowest effective tolerated dose carefully selected patients published elsevier inc
purpose review appraises currently available computer based silico models relating molecular structure low molecular weight compounds respiratory sensitization hazard present review places focus two main applications structure activity relationship sar models hypotheses disease mechanisms toxicological prediction recent findings analyses chemical structures low molecular weight organic compounds known caused occupational asthma led development mechanistic alerts usually based electrophilic reaction chemistry protein cross linking potential protein cross linking potential also found consistent feature chemicals caused human cases hypersensitivity pneumonitis stepwise iteration quantitative sar qsar modelling shown appreciable improvements predictivity occupational asthma hazard useful prospects practical application good case also made potential use structural alert based mechanistic sars predictive toxicology summary understanding molecular interactions chemical respiratory sensitizers components human proteins obtained vitro silico techniques developments qualitative mechanistic sars qsars offer potential use predictive algorithm toxicological screening industrial chemicals respiratory sensitization potential
migraine disabling headache disorder affects female population oestrogen withdrawal menstrual cycle hormone free interval users combined hormonal contraceptives chc plays pivotal role two diary based studies demonstrated positive impact progestin pill pop desogestrel frequency migraine attacks pain intensity studies chc users well nonusers included makes difficult distinguish effect taking women chc benefit pop present study compared therapeutic effect pop desogestrel migraine current chc users nonusers found positive influence desogestrel migraine women switched chcs desogestrel also used hormones months starting findings need confirmed prospectively conducted studies larger sample size
background performed systematic review meta analysis randomized controlled trials rcts evaluate efficacy safety pregabalin pain management following spine surgery methods september systematic computer based search conducted pubmed embase web science cochrane database systematic reviews rcts patients prepared spine surgery compared pregabalin placebo retrieved primary endpoint vas score rest mobilization hours hours hours cumulative morphine consumption hours hours secondary outcomes complications nausea sedation dizziness headache visual disturbances testing publication bias heterogeneity studies data aggregated random effects models necessary results ten clinical studies patients pregabalin group control group included meta analysis pregabalin associated reduced pain scores hours hours hours corresponding reduction points point hours points point hours points confidence interval point hours point numeric rating scale significant difference vas scores mobilization hours hours hours similarly pregabalin associated reduction cumulative morphine consumption hours hours furthermore pregabalin reduce occurrence nausea number needed treat significant differences occurrence sedation dizziness headache visual disturbances conclusions preoperative use pregabalin efficacious reduction postoperative pain total morphine consumption occurrence nausea following spine surgery sample size number included studies limited multicenter rct needed identify effects optimal dose pregabalin reducing acute pain spine surgery
research suggests fetuses open close mouth relation directed movements unclear whether mouth opening anticipates touch reaction touch analysis far facial area touch sequential ordering touch mouth movements prenatal development anticipation touch would expect frequency fetal mouth opening immediately preceding arriving hand mouth area increase fetal age fifteen healthy fetuses eight girls seven boys underwent four additional scans weeks gestation changes frequency touch different facial regions indicated significant decline touch upper side parts face significant increase touching lower perioral regions face increasing gestational age results supporting hypothesis showed significant increase proportion anticipatory mouth movements touch increasing around week gestational age additionally decrease proportion reactive mouth movements decreasing around week gestational age wiley periodicals inc
attributable fraction commonly used measure quantifies public health impact exposure outcome originally defined binary outcomes extension recently proposed right censored survival time outcomes called attributable fraction function maximum likelihood estimator attributable fraction function developed requires model outcome paper derive doubly robust estimator attributable fraction function estimator requires one model outcome one joint model exposure censoring estimator consistent either model correct necessarily
angiotensin converting enzyme inhibitor induced angioedema acei commen angioedema upper airway bradykinin receptor antagonist icatibant effective acei drug approved officially indication administered emergency situation label corticosteroids antihistamines seem work condition effectiveness esterase inhibitor acei must verified double blind study
backgroundfollicular unit extraction fue considered minimally invasive procedure injury donor area caused sharp punch may result dermal fibrosis clinically observed hypopigmentation objectiveto evaluate advanced image processing efficacy using normal saline minimizing injury donor area fue donor harvesting patients methodsthe term acute extraction used describe donor harvesting technique whereby follicular unit removed punch aligned parallel exit angle hair follicle term vertical extraction describes technique removed like manner normal saline injected intradermally prior harvesting punch perpendicular skin thirty five patients selected study apply harvesting techniques compare differences wound surface size skin mass removed punch resultsa significant reduction mean values wound surface skin mass recorded vertical extraction compared acute extraction conclusionthe injection normal saline prior harvesting proved efficient minimizing skin injury fue harvesting
increasing interest beneficial clinical effects mindfulness based interventions mbis research demonstrated efficacy wide range psychological conditions characterized emotion dysregulation neuroimaging studies evidenced functional structural changes myriad brain regions mainly involved attention systems emotion regulation self referential processing article review studies psychological neurobiological correlates across different empirically derived models research including dispositional mindfulness mindfulness induction mbis expert meditators relation emotion regulation perspective recent findings neuroscience emotion regulation discuss interplay top bottom emotion regulation mechanisms associated different mindfulness models phenomenological cognitive perspective authors argued mindfulness elicits mindful emotion regulation strategy however clinical perspective construct properly differentiated strategies interventions within mbis context propose distinction top bottom mindfulness based emotion regulation strategies furthermore propose embodied emotion regulation framework multilevel approach understanding psychobiological changes due mindfulness meditation regarding effect emotion regulation finally based clinical neuroscientific evidence mindfulness open perspectives dialogues regarding commonalities differences mbis psychotherapeutic strategies emotion regulation
broadcasting message one many processors network corresponds concurrent reading random access shared memory parallel machine computing trees forest level node tree path two nodes problems easily solved concurrent reading time logarithmic maximum height tree solving problems exclusive reading requires time logarithmic number nodes implying message passing disjoint pairs processors distributed system allowing concurrent reading parallel algorithm design distributed computing might advantageous practice problems faced shallow trees specific constraints show application lzc lempel ziv compress compressed file decoding whose parallelization employs computations trees realistic data hand zipped files advantage since compressed lempel ziv sliding window technique
scientists within materials engineering community produce wide variety data datasets differing size complexity examples include large volume densitometry files voxel generated microfocus computer tomography simple text files containing results tensile test increasingly need share data part international collaborations design suitable database schema architecture system cope varying information continuing problem management heterogeneous data present model flexible enough meet users diverse requirements metadata held using database design allows users control data structures data held file store combination metadata gives huge flexibility using examples materials engineering illustrate model applied elsevier ltd rights reserved
lesbian gay individuals reported show interest sex less interest sex toys playmates activities childhood heterosexual counterparts yet relevant evidence comes retrospective studies prospective studies clinically referred extremely gender nonconforming children addition findings mixed regarding relation childhood gender typed behavior later sexual orientation spectrum exclusively heterosexual exclusively lesbian gay current study drew sample girls boys population based longitudinal study found levels gender typed behavior ages years although less age years significantly consistently predicted adolescents sexual orientation age years sexual orientation conceptualized groups spectrum addition within individual change gender typed behavior preschool years significantly related adolescent sexual orientation especially boys results suggest factors contributing link childhood gender typed behavior sexual orientation emerge early development factors likely nonsocial nonheterosexual individuals appear diverge gender norms regardless social encouragement conform gender roles
recently changing security requirements computer networks many public key schemes introduced one major shortcoming identity based cryptosystems key screw certificateless public key cryptosystems introduced solve problem paper certificateless public key multiple key agreement scheme offered significant security properties perfect forward secrecy strong security zero knowledge proof scheme produces far shared hidden keys per session comparison many existing schemes paper security efficiency proposed scheme compared well known current schemes
background febrile neutropenia common cancer patients particularly hematologic malignancies due intensive cytotoxic chemotherapy important cause morbidity mortality treatment delays risk greater patients anc increases dramatically anc duration neutropenia week aims objectives purpose study evaluate incidence demographic characteristics clinical profile mortality outcome factors affecting outcome patients febrile neutropenia admitted center january november materials methods cases admitted institute january november analyzed data analyzed using ibm statistic spss version results total episodes reviewed hematologic malignancies accounted episodes episodes grade neutropenia significant association noted high serum bilirubin creatinine outcome isolation organism blood culture positive findings chest ray fungal infection associated higher mortality association transfusion requirements outcome analyzed observed patients multiple component transfusions single component ones significantly higher risk death deaths noted among patient population conclusion leukemias leading cause institute higher bilirubin creatinine chest imaging favoring pneumonia positive isolates multiple transfusions significant association mortality large scale prospective studies needed determine association preemptive therapy higher mortality outcome high risk study favorable
paper presents approach creating digital clothing application virtual dressing room clothes made digital scanning real clothes using rgb sensor creating digital clothing using specialized programs marvelous designer time consuming process scanning process relatively fast model acquired via registration different views rotating platform complete rotation performed approximately however achieved satisfactory results even rotations surface textured using rgb images acquired scanning process color occluded parts approximated via nearest neighbors knn show early results creating digital clothing high quality scanning real clothes
patients uterine leiomyosarcoma lms typically present vaginal bleeding pain pelvic mass atypical presentations hypercalcemia eosinophilia also reported radiographic evaluation combined positron emission tomography computed tomography may assist diagnosis surveillance women uterine lms commonly used stage tumour grade prognostic indicators recently developed risk assessment index predict disease specific survival recent studies shown addition adjuvant therapy surgical management seem improve survival ovarian preservation appear negatively impact outcome experimentally noteworthy proteasome subunit beta psmb beta deficient mice exhibit spontaneous development uterine lms disease prevalence similar months age furthermore recent report showed loss ability induce psmb beta expression regulated interferon gamma ifn gamma human uterine lms tissues reviewed human uterine lms genetic mutations ifn gamma signal cascade found serious mutations three genes janus activated kinase jak signal transducer activator transcription stat psmb beta promoter regions moreover molecular experiments demonstrated differential expression cyclin kip regulate cell cycle arrest via psmb beta expression discovery mutational activation key cell signalling pathway may provide new targets diagnostic approaches therapeutic intervention
concerns raised obesity public policy measures may harmful effects individuals eating disorders however little research investigated topic examined impact popular obesity public policy menu calorie labeling hypothetical food choices women disordered eating seven hundred sixteen adult females completed online survey randomly assigned receive restaurant menu without calorie information listed participants selected foods representative meal would choose consume answered questions restaurant ordering menu labeling participants completed eating disorder examination questionnaire fairburn beglin assess global eating pathology diagnoses anorexia nervosa bulimia nervosa binge eating disorder bed also derived measure generalized linear modeling examined impact menu label condition disordered eating menu label disordered eating interaction hypothetical food selection related variables disordered eating examined continuously menu labeling differentially affect food selections elevated disordered eating however examined eating disorder diagnosis participants ordered significantly fewer participants bed ordered significantly calories menu label versus label condition menu labeling may decrease calories ordered among individuals increase calories ordered among individuals bed
introduction impulsivity psychological phenomenon extensively studied headache patients aim assess presence impulsivity patients chronic migraine medication overuse patients patients examined outpatient headache clinic january march included episodic migraine diagnosed according ichd iii beta criteria prospectively gathered demographic clinical characteristics mood disorders evaluated using hospital anxiety depression scale hads impulsiveness assessed plutchik impulsivity scale results total patients included men women mean age years range patients presented among patient total met criteria anxiety depression impulsivity group showed higher scores hads anxiety hads depression among cases scores hads anxiety hads depression higher patients also found associations plutchik scale scores presence impulsivity either conclusion impulsivity common trait population migraine patients unlike mood disorders correlated either sociedad espanola neurologia published elsevier espana rights reserved
paper addresses potential korteweg vries equation singular soliton solution obtained aid ansatz method subsequently expansion method exp function approach also gives interesting solutions finally lie symmetry analysis leads another plethora solution equation results going extremely useful applicable applied mathematics theoretical physics
industrial deployment internet things iot provides development ideal platform decentralized management warehouses paper propose iot infrastructure collaborative warehouse order fulfillment based rfid ambient intelligence multi agent system consists physical devices layer middleware ambient platform multi agent system enterprise resource planning integrates bottom approach decision support mechanisms self organization negotiation protocols agents based com peration competition cooperation concept approach selected improve reaction capabilities decentralized management warehouses dynamic environment collaborative warehouse example conducted demonstrate implementation proposed infrastructure elsevier rights reserved
paper introduces comprehensive cooling index assess performance cooling systems data centers demonstrates application real case using cfd computational fluid mechanics method proposed methodology provides metric comparing ranking cooling efficiency air distribution configurations among available designs alternatives authors published elsevier ltd
article presents babysounds music therapy programme designed collaboration north south lanarkshire councils integrating children services early years collaborative national health service lanarkshire midwifery services case vignette titled cello belly describe cello served bridge communication learning confidence babysounds presented british association music therapy conference glasgow april demonstrating research outcomes provision sustainable resources health practitioners century
many countries put substantial investment constructing large iconic cultural buildings emblems civic pride well tools generalize cultural economic benefits however stories project failures often heard rapid cultural building boom fact many pitfalls developing large cultural building projects cbps associated stakeholders since actual central figures project addressing stakeholder complexity understanding major pitfalls cbps stakeholder perspective crucial successful management projects yet relevant empirical studies remain lacking fill gap case study large performing arts center conducted holistic stakeholder analysis approach applies rationalistic methods social network analysis empirical methods survey interviews adopted address stakeholder complexity case three major pitfalls large cbps identified including developing accurate end users requirements balancing aesthetics functionality resources leadership team makeup vision charisma learning stance underlying causes possible solutions discussed study contributes theoretically illustrating holistic approach analyzing addressing stakeholder complexity provides practical value understanding pitfalls cbps stakeholder perspective elsevier ltd apm ipma rights reserved
active actuator electro active polymer eap ionic polymer metal composite ipmc subjected alternating electric potential investigate study time delayed vibration characteristics generalized mathematical model actuator obtained assuming multi mode excitation applying hamilton principle lambert function applied closed form solution transcendental characteristic equation delay differential equation dde obtained delay differential equations ddes solved taking account experimental data physical properties ipmc results discussed validated
cassava marketed fresh form requires manual peeling later human consumption currently growing commercialization peeled cassava however processing done hand article presents study operation remove external shell inner shell cassava well others factors involved necessary build knowledge base required conceptual definition functional structure cassava peeling machine research delimited early stages design industrial products objective check whether relationship factors influence operation peeling functional structure cassava peeling machine methodology based reference model agricultural machinery development process focus activities pertaining phases informational conceptual design results establish analysis operation peeling determinants influencing factors complete definition functional structure global function remove external shell inner shell cassava consists four partial functions divide thirteen elementary functions ten functions derived influence factors initially identified thus possible verify existence relationship design influence factors functional structure cassava peeling machine demonstrating dependence settings made informational design phase tasks established conceptual design phase
report deals design intelligent support flight test data processing problem separate estimation aircraft thrust drag forces flight experiment thrust drag identification belongs class incorrect inverse problems reason solved general system identification methods applications aerodynamic parameter estimation flight data paper considers specific aspects intelligent support thrust drag identification automatic estimation viewpoint identification accuracy proposed algorithms tested set data generated using modern aircraft simulation facility authors published elsevier
central nervous system comorbidities identified patients epilepsy several comorbidities correlated poor surgery outcomes patient cohorts authors sought determine prevalence comorbidities pediatric epilepsy surgery patients families correlate long term seizure outcome cross sectional analysis three generation pedigrees elicited compare family history epilepsy adhd anxiety autism bipolar disorder cognitive disability depression migraine motor disability surgery outcomes patients proportions affected patients relatives compared general population comorbidity rates patients recent seizure outcome classification patients families significantly higher rates comorbidities general population poorer long term seizure outcomes following resective surgery associated autism cognitive disability patients together data support evidence common pathophysiological mechanism epilepsy central nervous system comorbidities
power feeding system attracted attention recent years since load dynamically changed system stability converter important paper presents stability analysis transient response digital integral gain changeable control converter using small output capacitance proposed method changes integral gain single logarithm function according load current verified proposed method obtain good transient response high stability even output capacitance small
year old male presented emergency room symptoms chest tightness palpitations following conversion atrial fibrillation sinus rhythm deep symmetrical wave changes electrocardiogram symptoms resolved almost immediately initial troponin negative underwent cardiac angiography utilizing emergency room triage protocol resulted diagnosis nonobstructive coronary artery disease apical hypertrophic cardiomyopathy following hospital stay less hours discharged outpatient follow medical management remained asymptomatic months case presentation illustrates example diversity pathology presents emergency rooms symptoms consistent acute coronary syndrome
indications hand surgeries include unremitting joint pain deformity stiffness often secondary arthritis several surgical options available including arthrodesis fusion joint arthroplasty classically arthrodesis performed situations poor bone stock supporting soft tissues arthroplasty reserved patients joints preservation function important bone stock soft tissue support adequate article review various techniques arthrodesis arthroplasty post surgical imaging appearance including key findings important surgeons findings indicate post surgical complications radiographs mainstay postoperative evaluation focus imaging portions review advanced imaging modalities reviewed applicable
malaria one important public health problems ethiopia objective study identify prevalence associated factors malaria among children presented investigation cross sectional health facility based study conducted october november east shewa zone oromia regional sate ethiopia blood samples finger pricks collected microscopic diagnosis malaria children age years symptoms suggestive malaria attending five health centers interview conducted parents guardians children using pre tested structured questionnaire bivariate multivariate logistic regression employed study associations malaria infection associated factors children provided blood samples microscopically confirmed malaria parasites predominant plasmodium species plasmodium vivax plasmodium falciparum whilst mixed infections species identified patients relative proportion respectively household ownership insecticide treated nets itns significantly associated decreased odds malaria infection adjusted odds ratio aor confidence interval however increased odds malaria infection observed among children years old aor compared children age years strong association reported household ownership itns malaria infection among children part ethiopia call continued efforts net distribution use control malaria turn might improve children health development elsevier rights reserved
order improve dynamic responses multimode controlled primary side regulation flyback converter novel digital control method proposed paper new dac sampling method capture output voltage dynamic transition introduced based dynamic module monitor variation output voltage improve dynamic performance proposed primary side regulation flyback converter maximum undershoot voltage overshoot voltage proposed control scheme study respectively much lower compared traditional control scheme maximum undershoot overshoot recovery times reduced respectively proposed control scheme verified fpga controlled prototype
objective purposes article describe concepts radiologists understand evaluate machine learning projects including common algorithms supervised opposed unsupervised techniques statistical pitfalls data considerations training evaluation briefly describe ethical dilemmas legal risk conclusion machine learning includes broad class computer programs improve experience complexity creating training monitoring machine learning indicates success algorithms require radiologist involvement years come leading engagement rather replacement
characterisation fatigue damage evolution constrained glass fibre reinforced plastic axis laminates presented newly developed imaging technique known automatic crack counting acc used quantify axis crack state constant amplitude variable amplitude block loading tension tension fatigue tests constant amplitude compression tension tests quantified crack states analysed combining newly developed acc method data mining approach applying large data sets obtained fatigue tests shown constant stress level stochastic nature axis crack initiation crack growth accurately modelled weibull distribution distribution parameters efficiently derived using developed approach data rich characterisation provides new insight crack density evolution process loading well derived weibull distribution parameters combination classical curves paris law relationship hence providing improved approach includes stochastic deterministic information physically based modelling crack density evolution fatigue loading elsevier ltd rights reserved
carbon nanofibers mixed polypropylene powder sonication method extruded filaments single screw extruder tensile tests performed single filament strain rate range min min results indicate tensile modulus yield strength materials increased increasing strain rate results also show infusing polypropylene nanofibers increases yield strength modulus decreases ductility increase strength modulus due well dispersion alignment cnfs
aging associated brain decline often result kind dementia even complex brain disorder physical model used order describe general behavior probabilistic model development dementia obtained fitted experimental data obtained alzheimer disease neuroimaging initiative explained dementia appears consequence aging irreversible elsevier rights reserved
system inertia reduction driven integration renewables imposes significant challenges primary frequency control electrification road transport reduces carbon emission shifting fossil fuel consumption cleaner electricity consumption also potentially provide flexibility facilitate integration renewables supporting primary frequency control context paper develops techno economic evaluation framework quantify challenges primary frequency control assess benefits evs providing primary frequency response simplified power system dynamic model used analyze impact declining system inertia primary frequency control technical potential primary frequency response provision evs furthermore advanced stochastic system scheduling tool explicitly modeling inertia reduction effect applied assess cost emission driven primary frequency control well benefits evs providing primary frequency response two representative system scenarios paper also identifies synergy pfr provision evs smart charging strategy well impact synthetic inertia wind turbines elsevier ltd rights reserved
nano barium ferrite bafeo prepared self propagating combustion synthesis xrd sem laser granularity analyzer used characterize structure micrographic morphology particle size products results show purity products high belongs hexagonal crystal structure magneto plumbite type ferrite particle size order research ability electromagnetic wave adsorption electromagnetic parameters measured vector network analysis similar ghz tangent value electromagnetic loss calculated accordingly mechanism electromagnetic wave adsorption explained last wave ghz attenuation tester used measure property reflection transmission results show barium ferrite bafeo favorable property electromagnetic wave adsorption range centimeter millimeter waves products applied field stealth technology military camouflage
objective endoscopic surgery revolutionized surgery ventral skull base yet widely adopted use cerebellopontine angle given relatively normal anatomy cerebellopontine angle patients trigeminal neuralgia authors hypothesized fully endoscopic microvascular decompression mvd might provide pain outcomes equivalent microscopic mvd mvd fewer complications methods authors conducted single institution single surgeon retrospective study patients treated period surgery patients completed questionnaire included validated multidimensional pain outcome tool penn facial pain scale pfps formerly known brief pain inventory facial point scale measures pain intensity interference general activities daily living adls facial specific adls using standardized script independent research assistants conducted follow telephone interviews results total patients available follow ups female patients underwent mvd underwent mvd preoperative characteristics classification pfps components medication use similar surgical groups except variables patients mvd group slightly higher incidence pain groups differed date surgery hence length follow years mvd group years mvd group trend toward finding neurovascular conflict time surgery frequently mvd mvd group internal neurolysis often performed mvd group groups significantly differ length mvd procedure approximately hours self reported headaches month postoperatively present patients mvd group versus mvd group pain outcomes recent followup equivalent patients reporting point improvement pain intensity point improvement pain interference adls point improvement interference facial specific adls actuarial freedom pain recurrence equivalent groups pain control years conclusions fully endoscopic mvd conventional mvd appear provide patients equivalent pain outcomes complication rates also similar groups exception rate headaches significantly lower mvd group month postoperatively
microrna mir highly expressed brain downregulated mirna expression profiles acute ischemic stroke patients however roles mir stroke known clinical relevance mir acute stroke patients evaluated real time pcr correlation analyses proliferation apoptosis microglial cells neuro cells cultured separately together oxidative stress inflammation assessed cell counting kit flow cytometry respectively cerebral ischemia induced middle cerebral artery occlusion mcao mice cerebral infarct volume microglia activation expression pro apoptotic factors evaluated triphenyl tetrazolium chloride staining immunocytochemistry western blotting respectively plasma levels mir decreased stroke patients relative healthy individuals positively correlated neutrophil number blood platelet count negatively correlated lymphocyte number lipopolysaccharide lps hydrogen peroxide treatment inhibited microglia proliferation without inducing apoptosis mir reduced proliferation increased apoptosis cells without lps treatment lps induced apoptosis neuro cells cultured cells effect potentiated mir mcao model mir agomir modestly increased infarct volume markedly decreased microglia activation cell lymphoma expression increased levels proapoptotic proteins ischemic brain data indicate mir contributes brain injury acute ischemic stroke promoting apoptosis microglia neurons via modulation pro anti apoptotic proteins
background precise mechanisms controlling homing effector teff cells inflamed gut crohn disease still unclear clinical outcome data patients inflammatory bowel disease treated anti alpha beta integrin antibody vedolizumab suggest differences ulcerative colitis methods expression homing molecules studied flow cytometry immunohistochemistry functional role investigated vitro adhesion assays humanized mouse model cell homing inflamed gut vivo results despite vitro blockade teff adhesion mucosal vascular addressin cell adhesion molecule madcam contrast previous observations ulcerative colitis anti alpha beta treatment result reduced teff cell homing colon vivo however integrin alpha beta expressed higher levels teffs patients compared controls expression peripheral blood declined expression intestine increased course clinical vedolizumab treatment consistently adhesion teffs vascular cell adhesion molecule vcam blocked inhibition alpha alpha beta vitro moreover vivo homing teffs ileum reduced inhibition alpha alpha beta integrins alpha beta integrins conclusions findings suggest teff cell homing ileum axis alpha beta vcam essential nonredundant pathway vivo possibly affecting efficacy clinical treatment antiadhesion compounds
increasing share variable renewable energy sources improving requirements system security reliability calling important changes energy systems synergies energy supply networks great importance satisfy development integrated energy system ies hence paper presents study coordinated scheduling strategy css models electricity network gas network developed detail operation constraints networks fully considered purpose css optimize conflicting benefits electricity network arid gas network daily operation ies satisfying operation constraints css multi objective optimization algorithm applied obtain pareto optimal solution set multiple attribute decision analysis mada using interval evidential reasoning ier developed determine final optimal daily operation solution ies simulation studies conducted ies consisting modified ieee bus electricity network node gas network verify effectiveness css evaluate interdependency electricity network gas network published elsevier ltd
geographic information system gis intelligence technique skilled extract store manage display spatial information various applications water resources management practically arid semi arid environments suffer several restrictions lack socio economic physical data limited precipitation poor rain water management research remote sensing approach integrated gis conducted estimate physical variables reservoir system elevation area volume curve first foremost computing accurate reliable elevation area volume curve challenging task purpose identifying optimal depth minimum surface area maximum reservoir storage accordingly field study consisting three constructed small earth dams demonstrated use geospatial approach western desert iraq elevation area volume curve extracted surface areas reservoir volumes obtained field survey spatial intelligence techniques compared comprehensive analysis carried evaluation purposes results indicate proposed approach efficiently applied remarkable level accuracy
paper deals brief history remarkable euler numbers gamma mathematical sciences included many properties constants gamma applications algebra geometry physics chemistry ecology business industry special attention given growth decay phenomena many real world problems including stability instability solutions specific modern applications logarithms complex numbers complex exponential functions electrical circuits mechanical systems presented examples included use complex numbers complex functions description analysis chaos fractals aid modern computer technology addition phasor method described examples applications engineering science major focus paper provide basic information historical approach mathematics teaching learning fundamental knowledge skills required students teachers levels understand concepts mathematics mathematics education science technology
modern heuristics metaheuristics optimization algorithms increasingly used last decades support complex decision making number fields logistics transportation telecommunication networks bioinformatics finance like continuous increase computing power together advancements metaheuristics frameworks parallelization strategies empowering types algorithms one best alternatives solve rich real life combinatorial optimization problems arise number financial banking activities article reviews works related use metaheuristics solving classical emergent problems finance arena non exhaustive list examples includes rich portfolio optimization index tracking enhanced indexation credit risk stock investments financial project scheduling option pricing feature selection bankruptcy financial distress prediction credit risk assessment article also discusses open opportunities researchers field forecast evolution metaheuristics include real life uncertainty conditions optimization problems considered
purpose purpose paper illustrate application six sigma define measure analyze improve control dmaic problem solving methodology portuguese industrial enterprise aimed reducing rejection rate specific manufactured product due defects generated aluminum gravity die casting operation design methodology approach along five stage roadmap set analytical conceptual tools systematically employed better characterize problem define product critical quality characteristics estimate process baseline determine relevant cause effect relationships identify root causes leading high rejection rate implement improvement plan determine effectiveness improvement actions put place control plan findings project team discovered high rejection rate caused factors inherent gravity die casting operation mixing rejected parts made different types alloys locations within plant another key finding successful execution project possible due belief support top management active involvement team members practical implications case study illustrates successful practical application six sigma project small medium enterprise portugal well operational financial benefits derived thus providing good example others follow originality value cases continual improvement initiatives including six sigma projects developed portuguese company available literature paper fills void describing successful application demonstrates advantages companies learn terms adopting structured methodologies improve quality products efficiency processes moreover analysis conclusions herein presented great importance companies using gravity die casting technology
paper novel low voltage ultra low power class current conveyor second generation based folded cascode operational transconductance amplifier ota floating gate differential pairs presented main features proposed conveyor design simplicity rail rail input voltage range low supply voltage proposed conveyor reduced power consumption due features proposed conveyor could successfully employed wide range low voltage low power analog signal processing applications pspice simulation results using cmos technology tsmc included prove results example application current mode quadrature oscillator designed functionality proved simulation
permeable geosynthetic tubes used dewatering waste sludge construction dikes embankments tubes inflated using sludge soil slurry several times inflation soil slurry consolidated solid hence second inflation onwards geosynthetic tube filled slurry consolidated soil paper new analytical method proposed provide solution specific case friction geosynthetic sheet soil friction geosynthetic tube subgrade considered parametric studies also carried compare design geosynthetic tubes inflated using pure slurry using slurry consolidated soil study key factors affecting design study shows tensile forces vary along cross section geosynthetic tube minimum value occurring center base effect friction lateral earth pressure geometry tensile forces geosynthetic tube insignificant height consolidated soil tube small increases considerably increase height elsevier ltd rights reserved
systematic generic procedure determination reasonable finished state self anchored suspension bridges proposed realization mainly adjustment hanger tensions initial hanger tensions first obtained iterative analysis combining girder tower finite element model analytical program shape finding spatial cable system initial hanger tensions together corresponding cable coordinates internal forces included model total bridge system nonlinear analysis involves optimization technique calculations repeated optimization algorithm converges optimal hanger tensions desired reasonable finished bridge state temperature rigid arm introduced offset unavoidable initial deformations girder tower due huge axial forces originated main cable moreover changing stiffness coefficient girder tower model stiffness proportion main girder tower cable subsystem whole structural system could adjusted according design intentions effectiveness proposed method examined demonstrated one simple tutorial example one self anchored suspension bridge
paper presents measurement campaign electrical thermal user comfort performance characterization energy storage systems real world electric bicycles specific sensors added characterize three vehicles differ electric motor energy storage system size control strategies controller implement energy recovery strategies braking change level electric assistance depending desired trade comfort driver battery duration experimental results show control strategy aiming preserving soc state charge together regenerative braking ensure long battery duration need recharge soc kept long period instead control strategies optimizing full comfort driver maximizing level assistance ensure real world bicycle missions soc battery drops
stage model social inference posits people categorize behaviors characterize actors situations effortlessly correct characterizations additional information effortfully current article tests model using developmental data assuming less cognitively demanding processes model categorization characterization appear earlier development whereas demanding correction process appear later development using different paradigms studies found younger children failed take situational information account characterizing actor study found younger children failed take dispositional information account characterizing situation contrast studies older children used available information correct characterizations actors situations consistent stage model elementary school years children start integrate additional information drawing explicit social inferences study children age levels used prior expectancy draw dispositional inference ignoring situational information suggesting characterizations based prior expectancies actor highly efficient process contemplated model studies together illustrate developmental data valuably used test adult socio cognitive models extend validity simply inform models
hereditary angioedema hae rare disease little known medical dental practitioners increasing hospitalization rate years hae due esterase inhibitor deficiency dysfunction leads increased vascular permeability airways affected life threatening laryngeal swelling may occur episodes hae clear cause triggered anxiety invasive procedures trauma hae important issue oral maxillofacial surgery otorhinolaryngology endoscopy emergency medicine anesthesiology even simple procedures may cause laryngeal edema recommendations management hae include long short term prophylaxis treatment acute attacks importance controlling anxiety underestimated report perioperative management nine hae patients scheduled oral surgery brief review literature topic
investigate analog single event transient aset generation operational amplifier using focused pulsed rays femtosecond laser pulses report improvements made pulsed ray experimental apparatus include normal incidence geometry high speed ray chopper allows reduce pulse repetition frequency synchrotron derived ray pulse train addition chopper allows measure asets long relaxation times show asets generated metallization equivalent pulse energy incident part ray response areas covered metal inaccessible laser different ray response areas metallization metal free use laser pulses generate asets metal free locations ray induced asets shapes asets generated two methods compared use differences seen two generation methods estimate charge generation collection produced pulsed rays estimate let would correspond heavy ions work shows pulsed rays used characterize analog devices single event effects
work used sensor based true random number generator order generate keys stream cipher based recently published hybrid algorithm mixing skew tent map linear feedback shift register stream cipher implemented tested field programmable gate array fpga able generate bit width data streams clock frequency mhz fast enough gigabit ethernet applications exhaustive cryptanalysis completed allowing conclude system secure stream cipher compared chaotic stream ciphers implemented similar platforms terms area power consumption throughput
paper studies simultaneous feature selection extraction supervised unsupervised learning propose investigate selective reduced rank regression constructing optimal explanatory factors parsimonious subset input features proposed estimators enjoy sharp oracle inequalities predictive information criterion model selection adapt unknown sparsity controlling rank row support coefficient matrix class algorithms developed accommodate various convex nonconvex sparsity inducing penalties used rank constrained variable screening high dimensional multivariate data paper also showcases applications macroeconomics computer vision demonstrate low dimensional data structures effectively captured joint variable selection projection
study analyzes economic activity bod biochemical oxygen demand relationships called dirty clean water polluting industries period results indicate economic activity environment trade dirty clean industrial sectors altered period study average pollution intensive dirty industries poorer nations found benefit terms bod emissions extra exports openness trade opposite true clean sectors increased trade openness seems contributed wider gap poorer richer nations pollution intensities openness trade skewing innovations away clean industries industrial sectors poorer countries specialize classical model opening economy lifting barriers technology adoption enough improve poorer nations water quality policies induce innovation reducing cost increasing return innovation particularly activities poorer countries comparative advantage necessary order improve economic activity environment relationship elsevier rights reserved
macroautophagy highly evolutionally conserved degradation process cytosolic materials including macromolecules proteins lipids damaged organelles broken basic components role autophagy elimination materials also serves dynamic recycling system produces new components energy cellular renovation homeostasis association autophagy organ physiology pathogenesis various disorders neurodegenerative diseases cancer infection inflammatory bowel disease revealed recent years autophagy also plays essential role cellular homeostasis kidney counteracts age related stress kidney diseases critically review current evidence regarding autophagy kidney particular assessed tissue cell lineage specific autophagy deficient mice better insight mechanisms underlying renoprotective roles autophagy pave way toward novel therapies kidney diseases
paper discusses apply advantage computer complete management work track field athletics make management work scientific systematic apply successful experience management expound theoretically track file athletics one major approaches pushing forward public sports extensive publicity therefore scientifically manage athletics important subject hold track field athletics usual organize people program copy program athletics proceed related work quite time consuming labor consuming besides easy cause errors addition takes long time finish layout printing cost also high competition necessary arrange several people copying make statistics scores sheet filled correctly statistics work quite easy cause errors bring inconvenience whole management computer technology brought sports scientific domain brings bright prospect management sports easy use brings accurate statistics save much time labor therefore become powerful tool management track field athletics gradually aroused great concern among sports workers paper focuses apply advantage computer finish management track field athletics make achieve scientific development discusses experience development application
bridge expansion joints adapt structure deformation bridge across device bridge structure couplet beam end beam end abutment back set free deformation role ensure bridge span structure temperature change concrete shrinkage creep load according static scheme influence factors free expansion deformation make car comfortable smooth waterproof prevent mud debris seam paper mainly discusses types advantages disadvantages highway bridge expansion joints well expansion joints discusses preventing curing diseases
rna puzzles collective experiment blind rna structure prediction report third round rna puzzles five puzzles structures riboswitch aptamers puzzle ribozyme structure included round experiment riboswitch structures include biological binding sites small molecules adenosyl methionine cyclic diadenosine monophosphate amino imidazole carboxamide riboside triphosphate glutamine proteins ybxf one set describes large conformational changes ligand free ligand bound states varkud satellite ribozyme recently solved structure known large ribozyme puzzles established biological functions require structural understanding appreciate molecular mechanisms use fast track experimental data including multidimensional chemical mapping accurate prediction rna secondary structure large portion contacts predicted correctly leading similar topologies top ranking predictions template based homology derived predictions could predict structures particularly high accuracies however achieving biological insights novo prediction rna structures still depends size complexity rna blind computational predictions rna structures already appear provide useful structural information many cases similar previous rna puzzles round experiment prediction non watson crick interactions observed high atomic clash scores reveal notable need algorithm improvement prediction models assessment results available hftp ahsoka ustrasbg rnapuzzles
direct oral anticoagulants doacs drugs used clinical practice since prevention stroke systemic embolism non valvular atrial fibrillation treatment secondary prevention venous thromboembolism four doacs including three factor inhibitors rivaroxaban apixaban edoxaban one direct thrombin inhibitor dabigatran provide oral anticoagulation therapy alternatives vitamin antagonists vkas despite clear advantages doacs require part internist thorough knowledge pharmacokinetic pharmacodynamic characteristics ensure correct use laboratory monitoring appropriate management adverse events document represents consensus paper use doacs representatives three italian scientific societies italian society internal medicine simi federation associations hospital managers fadoi society study haemostasis thrombosis siset document formulates expert opinion guidance pragmatic managing monitoring reversing anticoagulant effect doacs chronic emergency settings practical guidance may help internist create adequate protocols patients hospitalized ion internal medicine wards patients often elderly subjects affected poly morbidities renal insufficiency thus require particular attention drug drug interactions peri procedural protocols
depression anxiety stress moderate severe levels found university students hong kong respectively development screening tool assessing adjustment difficulties among tertiary education students helpful counseling professionals university student perception university support structure spuss scale based concepts articulated baumrind theory parenting styles measure supportive structured college environment present study used exploratory confirmatory factor analysis examine whether spuss structure consistent typology four parenting styles secondly factor scores used test hypothesis supportive structured university environment would associated students psychological adjustment indicated measures depression anxiety stress participants tertiary education students aged three hong kong universities spuss shows four factor structure consistent models parenting styles factor scores excellent psychometric properties factors represent students views university environment authoritative authoritarian permissive neglectful model different yau three factor data driven model identified factors representing psychological academic social adjustment study provides evidence validity higher scores authoritative factor related lower levels anxiety depression stress
erythromycin ery detection method proposed using fiber optic core decorated coatings silver layer ery imprinted nanoparticles synthesis ery imprinted nanoparticles carried using miniemulsion method operating range sensor observed sensor possesses linear response ery concentration range sensing method shows maximum sensitivity near ery concentration detection limit quantification limit sensor found respectively sensor applicability real samples also examined found good agreement industrial application sensor possesses numerous advantages like fast response time simple low cost highly selective along abilities towards online monitoring remote sensing analyte
review eddie glaude exodus politics racial solidarity exodus robert gooding williams argues despite sympathizing glaude conception racial solidarity finds glaude approach racial solidarity pragmatic enough precisely myth essential black subject still haunts claims contrary notwithstanding article challenges gooding williams reading exodus demonstrating despite grasp glaude conceptual map misses precisely stake glaude pragmatic notion racial solidarity understanding stake glaude conception racial solidarity one sees subtlety pragmatism actually resists lingering essentialism however article concludes showing despite glaude evasion gooding williams charge emphasis deweyan language problem solving courts criticism first place circumvent potential misunderstanding article emphasizes negotiation social practices alternative glaude emphasis language problem solving activity
paper presents investigation satellite radio access technology beyond imt systems although could see active role satellite system networks satellite system provide strong advantages future systems certain applications satellite link longer round trip delay terrestrial link need technologies would make satellite component especially efficient presenting satellite radio interface system suggest several points need considered beyond systems also suggest candidate technologies various simulation results
selenium non metal chemical element present human body trace quantities accumulates mostly thyroid gland selenium rich food includes offal meat meat products seafood milk dairy products yeast bread aim study collate discuss research results obtained last years regarding influence selenium diseases thyroid gland selenium deficiency lead number thyroid diseases proteins containing selenium called selenoproteins numerous functions human body identified research shows selenium essential proper synthesis activation metabolism thyroid hormones also postpone development hypothyroidism reduce level anti thyroid peroxidase antibodies tpoab thyroglobulin antibodies tgab normalize thyroid echogenicity ultrasound examination improve condition patients graves disease andautoimmune thyroiditis ait hashimoto thyroiditis reduce incidence postpartum thyroid dysfunction recommended dose selenium adults polish recommendations recommendations selenium may toxic effect doses therefore threshold adopted maximum safe dose role selenium supplementation diseases thyroid gland still subject discussion
removing geometric details computational domain significantly reduce complexity downstream task meshing simulation computation increase stability proper estimation sensitivity analysis error induced removing domain details called defeaturing errors ensure sensitivity analysis fidelity still met simplification paper estimation impacts removing arbitrarily constrained domain details analysis incompressible fluid flows studied applications fast analysis incompressible fluid flows complex environments derived error estimator applicable geometric details constrained either dirichlet neumann boundary conditions special requirements outer boundary conditions extensive numerical examples presented demonstrate effectiveness efficiency proposed error estimator
objective evaluate modified extended timed extended tug assessment panel validated clinical assessments indicator parkinson disease severity cognitive impairment methods eighty seven participants idiopathic sequentially recruited movement disorders clinic extended tug assessment employed required participants stand seated position walk straight line turn return start seated position extended tug assessment duration correlated panel clinical assessments including unified parkinson disease rating scale mds updrs quality life pdq scales outcomes parkinson disease scopa cog revised addenbrooke cognitive index ace barratt impulsivity scale bis results extended tug time significantly correlated mds updrs iii score scopa cog ace pdq scores generalized linear models determined extended tug sole variable predicting ace scopa cog scores patients fastest extended tug tertile predicted perform points better scopa cog ace assessments respectively slowest group patients exceeded dementia cut scores instruments exhibited significantly longer extended tug times conclusions extended tug performance appears useful indicator cognition well motor function quality life warrants evaluation first line assessment tool monitor disease severity response treatment poor extended tug performance may identify patients without overt cognitive impairment form cognitive assessment needed elsevier rights reserved
objective reproductive coercion birth control sabotage coercion male partners become pregnant control outcome pregnancy associated history intimate partner physical sexual violence tpv unintended pregnancy among females utilizing reproductive health services temporal nature associations unintended pregnancy distinct impact however remained less clear study design survey administered females aged years seeking care rural urban family planning clinics pennsylvania results five percent respondents reported past months reported unintended pregnancy past year among reported recent reported past year unintended pregnancy compared women exposed neither condition exposure recent increased odds past year unintended pregnancy absence history ipv adjusted odds ratio aor combination history ipv aor history ipv without recent also associated unintended pregnancy aor conclusions findings indicate temporal proximity association unintended pregnancy recent related past year unintended pregnancy independently combination history ipv recent relatively prevalent among young women using family planning clinics associated increased risk past year unintended pregnancy even absence ipv implications recent history ipv prevalent among female family planning clients particularly younger women experiences associated unintended pregnancy pregnancy prevention counseling include assessment physical sexual partner violence also specific inquiry elsevier inc rights reserved
accelerating progress availability low cost computers high speed networks software high performance distributed computing allow reconsider computationally expensive techniques image processing pattern recognition propose two level hierarchical nearest neighbor classifier first level uses graphics processor units gpus second level uses high performance cluster hpc system evaluated problem character recognition nine databases arabic digits indian digits bangla devnagari oriya bangla characters indonesian characters arabic characters farsi characters digits contrary many approaches tune model different scripts proposed image classification method unchanged throughout evaluation nine databases show hierarchical combination decisions based two distances using gpus hpc provides state art performances several scripts provides better accuracy complex systems
paper develops novel approach estimating latent state variables dynamic stochastic general equilibrium dsge models solved using second order accurate approximation apply kalman filter state space representation second order solution based pruning scheme kim econ dyn control contrast particle filters stochastic simulations needed deterministic filter present method thus much faster terms estimation accuracy latent states competitive standard particle filter use pruning scheme distinguishes filter deterministic quadratic kalman filter presented ivashchenko comput econ filter performs well even models big shocks high curvature
aimsthe main purpose verify potent capacity neurotropin neuronal damage hippocampus explore underlying mechanisms methodsht cells treated mol presence various concentrations neurotropin absence cell viability assessed cck assay flow cytometry used measure cell apoptosis intracellular ros levels mitochondrial membrane potential plaques examined bielschowsky silver staining activities antioxidants detected hippocampus app mice neurotropin treatment expression proteins including hif bcl bax mapks signaling molecules evaluated western blot resultsneurotropin significantly reversed cell injury induced increasing cell viability mitochondrial membrane potential decreasing intracellular ros cell apoptosis cells furthermore neurotropin markedly reduced formation plaques upregulated activities antioxidants additionally protein expression hif erk jnk significantly inhibited hippocampus app mice conclusionsneurotropin exhibited potent neuroprotective effect inhibiting induced oxidative damage alleviating deposition hippocampus via modulation hif mapk signaling pathway
conceptual model proposed explains gene environment correlations multiplier effect function context social development individuals autism review discusses current state autism genetic research including challenges genetic phenotypic heterogeneity disorder limitations lack interdisciplinary work geneticists social scientists discuss literature gene environment correlations context social development draw implications individuals autism review expands upon genes behaviors types environmental exposure exogenous variables relevant social development individuals autism spectrum explains factors context conceptual model provide depth understanding effects certain genetic variants multiplied environment cause largely phenotypic individual differences using knowledge gathered gene environment correlations multiplier effect outline novel intervention directions implications
paper proposes concise effective approach termed discriminative feature representation dfr low dose computerized tomography ldct image processing currently challenging problem medical imaging field dfr method assumes ldct images superposition desirable high dose hdct features undesirable noise artifact features combined term noise artifact features induced low dose scan protocols decomposed hdct features used provide processed ldct images higher quality target hdct features solved via dfr algorithm using featured dictionary composed atoms representing hdct features noise artifact features study featured dictionary efficiently built using physical phantom images collected scanner target clinical ldct images process proposed dfr method also good robustness parameter setting different scanner types dfr method directly applied process dicom formatted ldct images good applicability current systems comparative experiments abdomen ldct data validate good performance proposed approach
objective investigate validity test retest reliability sensitivity change feasibility dual task assessments patients dementia design validation study setting post ward rehabilitation participants geriatric patients dementia age mmse score main outcome measures psychometric quality performance different tests analyses performed motor cognitive performance relative costs dtcs results spearman rank correlations examined tests moderate high motor tasks small high cognitive tasks small high relative dtcs motor dtcs cognitive dtcs combined dtcs correlations external assessment moderate high motor tasks small moderate cognitive tasks small moderate relative dtcs motor dtcs cognitive dtcs combined dtcs test retest reliability excellent motor tasks icc fair excellent cognitive tasks icc poor good relative dtcs motor dtcs icc cognitive dtcs icc combined dtcs icc sensitivity change acceptable excellent trained tests effect sizes small large gait parameters srm large cognitive tasks srm small large relative dtcs motor dtcs srm cognitive dtcs srm combined dtcs srm completion time ranged min conclusions tests showed acceptable excellent psychometric properties patients dementia highest quality gait based tests walking counting walking reciting abc elsevier rights reserved
paper proposes method model constraints different models run optimization models different granularities machine learning proposed method proven able accurately map constraints minimize number call model handles continuous discrete variables mixes design rules statistic approach create surrogate model
report case discordant phenotypic sex monozygotic twins mosaic xxy monozygotic heterokaryotypic twins twins presented cognitive comprehension delay behavioural language disorders symptoms frequently reported klinefelter syndrome molecular zygosity analysis several markers confirmed twins effect monozygotic array comparative genomic hybridization found evidence implication copy number variation phenotypes ultrasound scans reproductive organs revealed abnormalities endocrine tests showed low testosterone level twin male phenotype low gonadotrophin level twin female phenotype combined results ultrasound examination provided useful information potentially predicting future fertility potential twins blood karyotypes revealed presence normal cell line aneuploid xxy cell line patients examination chromosome constitutions various tissues blood buccal smear urinary sediment surprisingly showeddifferent proportions xxy cell lines likely explains discordant phenotypic sex mild klinefelter features plausible underlying biological mechanism post zygotic loss chromosome initially xxy zygote would result embryo xxy cells lines could subsequently divide two monozygotic embryos twinning process two cell lines would distributed differently tissues could result phenotypic discordances twins observations emphasize importance regular paediatric evaluations determine optimal timing fertility preservation measures detect new klinefelter features could appear throughout childhood two subjects
acetylcholinesterase ache inhibitors currently widely prescribed drugs alzheimer disease high potential indole compounds medicinal chemistry led discover novel series fluoroindole compounds synthesis pharmacological analysis difluoropyrido indoles described compounds tested ache inhibition activity using rat brain homogenate compounds display promising vitro profile value range show significant protective effect scopolamine induced amnesia present data indicate compounds may represent attractive potent molecules treatment alzheimer disease
longitudinal qualitative study sought understand livelihood intervention affected health health behaviors hiv infected kenyan adults intervention included microfinance loan agricultural financial training human powered water pump depth interviews conducted two time points intervention control participants program staff double coded interviews used thematic content analysis transcripts following integrative inductive deductive approach intervention participants described improvements hiv health including increased counts energy improved viral suppression fewer hiv related symptoms better health linked improved clinic attendance art adherence several mechanisms reductions food insecurity abject hunger improved financial stability improved productivity enhanced social support better control work situations renewed desire prioritize health livelihood interventions may improve health influencing upstream determinants health behavior including food security poverty
background computational evolution system ces knowledge discovery engine identify subtle synergistic relationships large datasets pareto optimization allows cess balance accuracy model complexity evolving classifiers using pareto optimization ces able identify small number features maintaining high classification accuracy ces designed various types data user exploit expert knowledge classification problem order improve discrimination classes characteristics give ces advantage classification feature selection algorithms particularly goal identify small number highly relevant non redundant biomarkers previously cess developed binary class datasets study developed multi class ces results multi class ces compared three common feature selection classification algorithms support vector machine svm random nearest neighbor rknn random forest algorithms evaluated three distinct multi class rna sequencing datasets comparison criteria run time classification accuracy number selected features stability selected feature set measured tanimoto distance performance algorithm data dependent ces performed best dataset smallest sample size indicating ces unique advantage since accuracy classification methods suffer sample size small conclusion multi class extension ces increases appeal application complex multi class datasets order identify important biomarkers features
residence times connectivity computed subregions urban man made lake china using high resolution tracer transport model renewal timescales explicitly defined computed two groups four freshwater inflow scenarios related water diversion projects first timescale values computed compared using different computational criteria upper limit integration residence time equation sensitivity analysis suggests calculation time days necessary satisfy relative error cutoff value criteria secondly residence times range days low high flow conditions respectively water inner lake would reside lake less days prior exiting region interest timescale values applied impact studies investigate extent sudden water pollution events initially affect subdomain lake finally lacustrine residence times decomposed different subregion residence times resulting connectivity matrix matrix illustrate preferential connections among individual subregions reveal hidden patterns relating local hydrodynamics lake
present timefork interactive prediction technique support users predicting future time series data financial scientific medical domains timefork combines visual representations multiple time series prediction information generated computational models using method analysts engage back forth dialogue computational model alternating manually predicting future changes interaction letting model automatically determine likely outcomes eventually come common prediction using model computer supported prediction approach allows harnessing user knowledge factors influencing future behavior well sophisticated computational models drawing past performance validate timefork technique conducted user study stock market prediction game present evidence improved performance participants using timefork compared fully manual fully automatic predictions characterize qualitative usage patterns observed user study
population middle aged older adults meeting national guidelines exercise purpose study describe factors associated exercise adherence month program offered part research study testing effects exercise cognitive performance persons family history alzheimer disease completion program participants provided open ended responses indicating reasons adhering exercise program completed motives physical activities measure revised results indicated adherence tied interest contributing understanding opportunity join exercise program perceived exercise benefits social support addition participants reported high levels extrinsic fitness related intrinsic interest enjoyment motivation possible motivating factors emerged day day observations program identified findings suggest directions exercise professionals respect exercise adherence
visual data classification aimed determining unique label class increasingly important issue machine learning community recent years increasing attention paid application metric learning classification proven good way obtain promising performance however result limited training samples data complex distributions vast majority algorithms usually fail perform well motivated develop novel locally adaptive maximum margin metric learning lam algorithm order maximally separate similar dissimilar classes based changes distances maximum margin metric learning experimental results two widely used uci datasets real hyperspectral dataset demonstrate proposed method outperforms state art metric learning methods
background two old drugs choice trypanosoma cruzi little known secondary effects acute stage oral transmitted chagas disease chd methods cross sectional analytical surveillance study conducted sizable cohort patients seen largest acute foodborne chd microepidemic registered far individuals treated benznidazole bnz nifurtimox nfx common terminology criteria adverse events assessed categorize side effects according severity results treatments applied one adverse effects predominated adults compared children risk side effects nfx significantly higher bnz four adults child treated nfx severe side effects pulmonary infarction facial paralysis neutropenia blurred vision bone marrow hypoplasia warranting hospitalization drug suspension adverse effects frequently reported nfx abdominal pain hyporexia weight loss headache nausea lymphocytosis whereas skin rash neurosensory effects hyporexia fatigue pyrosis abdominal pain eosinophilia observed bnz conclusions frequency severity side effects treatment acute oral infection cruzi demand direct supervision close follow even asymptomatic prevent life threatening situations
uruguay bolivia two countries show heterogenicity latin american region including national income expenditure health services renal care bolivia manpower shortage renal care nephrologists per million people pmp prevalence patients dialysis pmp much lower mean prevalence rate renal replacement therapy latin america whole uruguay hand dedicated renal resources nephrologists pmp renal replacement therapy provided similar dialysis patients pmp november collaborative project financed uruguayan international cooperation agency signed uruguay bolivia ministries health goal develop comprehensive program prevention management stages chronic kidney disease ckd bolivia specific objectives promote renal healthcare primary healthcare setting identify kidney disease populations risk optimize patient care stages ckd including dialysis transplantation supported national esrd registry bolivia first step delegates bolivian health ministry visited uruguay april primarily strengthen development tools required developing maintaining national registry addition visit meeting president latin american society nephrology hypertension slanh culminated designing training program peritoneal dialysis highly cooperative relationship advancing prevention care ckd bolivia may serve model international approaches advance system level ckd care countries limited healthcare resources
paper proposed several real life applications big data analytic using parallel computing software parallel computing software consideration parallel virtual machine matlab distributed computing server compute unified device architecture simulate big data problems parallel computing able overcome poor performance runtime speedup efficiency programming sequential computing mathematical models big data analytic based partial differential equations obtained large sparse matrices discretization development linear equation system iterative numerical schemes used solve problems thus process computational problems summarized parallel algorithm therefore parallel algorithm development based domain decomposition problems architecture difference parallel computing software parallel performance evaluations distributed shared memory architecture investigated terms speedup efficiency effectiveness temporal performance
scene change detection multitemporal image scenes used interpret variation regional land use significant potential application urban development monitoring semantic level traditional methods directly comparing independent semantic classes neglect temporal correlation thus suffer accumulated classification errors paper propose novel scene change detection method via kernel slow feature analysis ksfa postclassification fusion integrates independent scene classification scene change detection accurately determine scene changes identify transition type representation bag visual words model ksfa proposed extract nonlinear temporally invariant features better measure change probability corresponding multitemporal image scenes two postclassification fusion methods based bayesian theory predefined rules respectively employed identify optimal coupled class combinations multitemporal scene pairs furthermore addition identifying semantic changes proposed method also improve performance scene classification since unchanged scenes likely belong class two experiments high resolution remote sensing image scene data sets confirm proposed method increase accuracy scene change detection scene transition identification scene classification
background microvascular free fibula flap become gold standard reconstruction complex mandibular defects since description hidalgo prior studies demonstrated safety efficacy pediatric population however reconstructive method often used last resort correction congenital mandibular hypoplasia failure bone grafting distraction osteogenesis authors describe experience using technique facilitated virtual planning prefabricated cutting jigs children severe congenital mandibular hypoplasia methods patients mandibular reconstruction fibula flap children congenital mandibular hypoplasia senior authors identified patient underwent preoperative computed tomography scanning virtual surgical planning create custom cutting jigs creation mandibular defect fibular osteotomies preoperative intraoperative postoperative medical records examined detail results five patients age congenital mandibular hypoplasia pruzansky grade iii mandibles underwent microvascular free fibula flap mandibular reconstruction period flap success rate patients underwent subsequent revision procedures improve symmetry hardware removal patients series required dental implants able placed mandibular reconstruction conclusions preoperative virtual planning prefabricated cutting jigs allow precise complex fibula reconstruction mandible pediatric population additionally virtual planning facilitates concomitant orthognathic procedures patients hemifacial microsomia early success patient population leads suggest free fibula safely successfully used multiple prior surgical interventions anatomic region also powerful tool primary correction congenital mandibular hypoplasia
paper presents geotechnical studies carried seismic design one span suspension bridge across messina strait connect sicily mainland italy studies included advanced geotechnical characterisation situ laboratory tests estimate site stability involving liquefaction analysis submerged slope stability evaluation soil foundation stiffness spectral analysis superstructure static calculations evaluation anchor block performance seismic conditions full dynamic analyses soil structure interaction paper summarises main results obtained geotechnical characterisation foundation soils reports approach adopted evaluating seismic performance anchor blocks modified newmark type calculation presents study soil structure interaction carried series two dimensional plane strain numerical analyses analyses addition embedded foundation elements models included simplified structural description bridge towers specifically designed reproduce first vibrations modes deemed significant influence system dynamic response illustration limited foundation systems bridge located sicily shore
epistemic contextualism one hotly debated topics contemporary epistemology contextualists claim know context sensitive verb associated different evidential standards different contexts contextualists motivate view based set behavioural claims paper show several behavioural claims false also show contextualist test cases suffer critical confound derives people tendency defer speakers statements mental states evidence consists results several behavioural experiments conclude contextualism idle hypothesis propose general methodological lessons
cumulative irritation test cit accepted method used evaluate skin irritation potential safety individual ingredients formulas leave skin care cosmetic compounds report results cits collected johnson johnson consumer companies inc skillman part extensive tiered program evaluate product safety cit test formulations applied skin adults years known skin disease allergies times per week weeks using semi occlusive clinical patches preservatives components test formulas included ethylenediaminetetraacetic acid diazolidinyl urea bis hydroxymethyl dimethylimidazolidine dione parabens isothiazolinone phenoxyethanol sorbates benzoates skin sites scored patch removal using point scale visible reaction erythema marked edema substantial vesiculation scores reported percentage maximal irritation score data analyzed cit studies subjects significant differences percentage maximal scores formulas grouped preservative types median score across entire dataset formulas showing none mild irritation although seasonal variations observed correlation noted score preservative concentration conclusion large normal subject dataset preservatives typical use concentrations appear contribute skin irritation
childhood risky behaviors always result adverse health outcomes behaviors greatly affected social environment individual factors however studies explored social determinants schoolchildren health behaviors cross sectional study social determinants health behaviors examined among migrant resident students beijing china data children six urban suburban primary schools analyzed using multiple linear regression analysis results showed less children performed healthy behaviors although health knowledge generally good children health behavior scores greatly determined school characteristics health knowledge demographic characteristics family context therefore improving health education conditions primary schools priority promote children healthy behaviors especially disadvantaged children
letter new alternative configuration slotted radiating elements substrate integrated waveguide siw proposed yields greater control transmission phase slotted waveguide section allows precise conception traveling wave slot antennas siw including high width height ratio altering phase internal measures instead displacing slots revealed suitable achieving good side lobe performance broadside beam less computation effort sake multiple vias inserted sophistically elements upholding low reflection unaffected radiation simplified yet bidirectional signal flow graph completes straightforward approach validation carried first comparing slot amplitudes three different arrays designed different procedures ideal desired values second fabricated simulated circuits evaluated terms reflection radiation performance good results demonstrate new alternative way configure slot antenna traveling wave architecture good candidate particular low effort applications matlab test script provided validation design wiley periodicals inc microwave opt technol lett
objectives bipolar disorder requires psychiatric medications even guideline concordant treatment fails bring many patients remission keep euthymic address gap researchers developed adjunctive psychotherapies purpose paper critically review evidence efficacy manualized psychosocial interventions bipolar disorder methods conducted search literature examine recent present randomized controlled studies following psychotherapy interventions bipolar disorder psychoeducation cognitive behavioral therapy cbt interpersonal social rhythm therapy ipsrt dialectical behavior therapy dbt mindfulness based cognitive therapy mbct family therapies family focused therapy fft results psychotherapy interventions appear effective reducing depressive symptoms psychoeducation cbt associated increased time mood episode relapse recurrence mbct demonstrated particular effectiveness improving depressive anxiety symptoms online psychotherapy interventions programs combining one psychotherapy interventions targeted interventions centering particular symptoms focus recent randomized controlled studies bipolar disorder conclusions psychotherapy interventions treatment bipolar disorder substantial evidence efficacy next challenge disseminate psychotherapies community elsevier rights reserved
emergency contraception serbia available two products levonorgestel nonprescription status ulipristal acetate prescription medicine considering dispensing statuses gynecologists pharmacists health care professionals hcps widest impact use yet little known beliefs practices regarding medicines surveyed gynecologists october october community pharmacists january april results showed significant differences two groups suggesting provision users may inconsistent gynecologists convinced pharmacists would reduce abortion rate versus however concerned pharmacists easy access would cause less regular contraceptive use versus risky sexual behaviors including initiating sexual activity younger age versus sexual partners versus additionally pharmacists gynecologists versus said would provide anyone circumstance even victims sexual assault results indicated need reevaluating establishing official guidelines dispensing practices
objective pilot study comparison dimensional models assessing personality traits personality pathology clinical sample adults diagnosed adhd adults diagnosed borderline personality disorder bpd nonclinical control sample healthy adults method personality traits assessed using neo personality inventory revised neo dimensional personality pathology dimensional assessment personality pathology basic questionnaire dapp results adults adhd bpd produced higher emotional dysregulation neuroticism dissocial behavior scores controls extraversion inhibitedness scale adults bpd produced significantly lower scores adults adhd controls conscientiousness compulsivity domains conscientiousness scores lower disorders whereas low compulsivity values specific adult adhd conclusion results suggest patients adult adhd bpd distinguishable profiles personality traits personality pathology
work classical derivation fractional order circuits models presented generalised constitutive equations terms fractional riemann liouville derivatives introduced maxwell equations circuit element next kirchhoff voltage law applied rcl circuit configuration shown basic properties fractional calculus fractional differential equation model caputo derivatives obtained thus standard initial conditions apply finally models bioimpedance revisited elsevier rights reserved
background determination regulation cell morphology critical components cell cycle control fitness development single cell multicellular organisms understanding environmental factors chemical perturbations genetic differences affect cell morphology requires precise unbiased validated measurements cell shape features results introduce two software packages morphometrics blurlab together enable automated computationally efficient unbiased identification cells morphological features applied tools bacterial cells small size cells subtlety certain morphological changes thus far obscured correlations bacterial morphology genotype used online resource images keio knockout library nonessential genes gram negative bacterium escherichia coli demonstrate cell width width variability length significantly correlate drug treatments nutrient changes environmental conditions combined morphological classification genetic variants genetic meta analysis reveal novel connections among gene function fitness cell morphology thus suggesting potential functions unknown genes differences modes action antibiotics conclusions morphometrics blurlab set stage future quantitative studies bacterial cell shape intracellular localization previously unappreciated connections morphological parameters measured software packages cellular environment point toward novel mechanistic connections among physiological perturbations cell fitness growth
objective assess benefit intra articular injection botulinum toxin bont chronic refractory joint pain regardless joint pathology data sources search performed ovid medline process non indexed citations ovid medline ovid embase web science scopus inception week trial selection clinical randomized controlled trials evaluated bont intra articular injection patients refractory joint pain included data extraction two independent reviewers conducted data extraction results total records included analysis indicated statistically significant decreased pain score found bont therapy group control group wmd wmd week injection respectively womac score also significant decreased bont therapy group control group wmd wmd week injection respectively difference adverse event bont therapy group control group conclusion compared conventional therapy bont intra articular injection beneficial effects improved pain score womac score adult patients refractory joint pain
objective eating disorders obesity suggested involve spectrum self regulatory control difficulties temporal discounting tasks used explore idea systematic review examines behavioural neuroimaging data obesity method using prisma guidelines reviewed relevant articles medline psycinfo embase inception august studies reported behavioural differences neuroimaging data obesity included results thirty one studies included limited data suggest bed obesity associated increased whilst data mixed aberrant neural activity frontostriatal circuitry implicated tasks vary widely obesity may vary according factors illness stage conclusion findings suggest altered self regulatory control obesity tasks heterogeneous limiting generalisability findings research whether multidimensional along transdiagnostic neuroimaging research needed assessment may useful psychoeducation outcome prediction treatment obesity elsevier ltd rights reserved
objective safety outcomes intravenous thrombolysis ivt stroke patients via telestroke similar presenting stroke centers little known accuracy diagnosis among receiving ivt sought compare rate patients receiving ivt diagnosis ischemic stroke opposed stroke mimic network presented comprehensive stroke center csc materials methods consecutive patients receiving ivt august june identified csc network compared rates post ivt symptomatic intracerebral hemorrhage sich hospital mortality discharge destination results evaluated receiving ivt included analysis rates receiving ivt similar csc versus four stroke patients experienced sich hospital mortality neither found among patients discharge destination similar stroke patients patients higher diagnoses migraine psychiatric illness conclusion accuracy diagnosing stroke ivt eligible patients evaluated via similar evaluations csc continued efforts made minimize exposure patients ivt settings elsevier rights reserved
paper presents system modeling method multi stage operational amplifier circuit based step response experiment taking step voltage signal input measure data collected estimating system parameters defining minimizing output error criterion function newton iterative estimation algorithm derived order show accuracy estimated circuit model use proportional integral controller construct closed loop operational amplifier circuit terms estimated circuit model moreover take step experiment test tracking performance operational amplifier circuit simulation results indicate proposed method generate parameter estimates multi stage operational amplifier circuit system
traditional approaches managing enterprise data revolve around batch driven extract transform load process one size fits approach storage application architecture tightly coupled underlying data infrastructure emergence big data technologies led creation alternate instantiations traditional approach one storage systems moved relational databases nosql technologies like hdfs approach data management found wanting enterprises begin deal complex heterogeneous data especially area internet things iot iot environments characterized data producers data processing requirements paper articulate shortcomings traditional approaches data management context iot identify challenges brought forth due content heterogeneity requirements scale robustness etl processes need rapidly onboard support multiple applications analytics approach introduces linked enterprise data model ledm knowledge representation approach derived linked data modeling linking disparate aspects data infrastructure leverage model developing scalable robust etl framework framework adopts lambda architecture approach supports stream batch processing incoming data build capability streaming leg lambda architecture comprising amazon kinesis apache spark streaming amazon dynamo
controlling images central reproduction racial class gender inequality yet dearth knowledge pertaining latinos drawing sixty two depth life history interviews latino men ask controlling images latinos gang members sports athletes impose constraints channel emotions latinos respond images document institutions people deploying controlling images blockade access education upward mobility find life course stage shapes latinos responses imagery youth latino respondents used emotional strategies resist racial subjugation adults respondents resisted racist controlling images leadership activities professional realm since adults possess social power youth adults better equipped engage leadership endeavours resistance compared youth constrained age predominately utilized emotional resistance strategies
amyloid beta beta plays pivotal role pathogenesis alzheimer disease clearance beta promising therapeutic strategy previously demonstrated peripheral organs play important roles clearance brain derived beta present study recruited patients liver cirrhosis normal controls found plasma beta beta levels significantly higher cirrhosis patients normal controls notably cirrhosis patients hepatitis virus hbv infection higher plasma beta beta levels hbv negative cirrhosis patients besides cirrhosis patients significantly higher plasma levels interleukin beta beta plasma tumor necrosis factor alpha tnf alpha interferon gamma ifn gamma levels significantly different groups moreover found significant correlations hepatic functions plasma beta beta levels plasma levels also significantly correlated plasma beta levels however linear regression model found significant correlation plasma beta levels hepatic functions plasma levels results indicate hepatic dysfunctions might result decreased peripheral beta clearance liver protecting hepatic functions might helpful clearance brain derived beta blood
objective study examine association useing ict sleep disturbances among japanese adolescents widely extended using mobile phone pcs students due promotion ict sns also learning mobility learning trail study designed two famous survey morning evening sleep evaluation ostberg internet addiction test young respectively jissen womenn university ethics committee approved survey requested several schools fill self reported questionnaires using web screen person total adolescent responded collected data analysis medium degree internet addiction typical tendency observed exponential increase university admission student clearly morning type sleep conditions three results classification sleep conditions almost evening type evening type morning type respectively calculated normalized value score internet addiction morning evening sleep condition analysis variance study showed use internet calling internet addiction significant different sleep conditions however limitation small effect size study studies examine wide association necessary educate strategies healthy sleep condition ict development
choice electric racing car traction motor one main tasks designing electric racing car motor specifies dynamic high speed characteristics besides electric drive must within regulations competition comparing electromechanical characteristics electric motors used electric racing car necessary prefer electric drives hardening characteristic despite fact result increase expenses copper well upgrade technical requirements choice storage batteries hardening vertical bar characteristic provide model required dynamics widely spread motors hardening characteristic direct current motor separate excitation however motor disadvantages related specific structure analysis different versions electric drives shown prospects use synchronous motors constant magnets authors published elsevier ltd
epha ephrin receptor tyrosine kinase overexpressed hematologic malignancies performed first human multicenter phase study anti epha monoclonal antibody refractory hematologic malignancies order determine safety tolerability along secondary objectives pharmacokinetics pharmacodynamics assessments well preliminary assessment efficacy patients enrolled dose escalation phase dep initially followed cohort expansion phase cep administered intravenous infusion days day cycle escalating doses total patients aml mds mpn mds dlbcl received dep additional patients treated cep aml mds common toxicities transient grade grade infusion reactions irs patients irs dose limiting sustained exposure exceeding predicted effective concentration covering day interval doses achieved responses observed patients aml mds mpn mds study well tolerated clinically active given weekly infusion elsevier ltd rights reserved
objective stimulation nerve growth factors focused transcranial extracorporeal shock wave therapy teswt made effective persons within unresponsive wakefulness syndrome apallic syndrome design eight years brain lesion five patients unresponsive wakefulness syndrome differing severity received teswt device duolith storz medical four week physicomedical complex therapies previous years treated complex therapies without teswt vigilance change results two four years average treatment series patients abilities improved german coma remission scale krs glasgow coma scale motor area krs patients improved three peg feeding tubes could removed nonverbal communication initiated four times conclusion longitudinal observation study focused teswt stimulated vigilance patients unresponsive wakefulness syndrome precise neurophysiological effects remain verified study clinical results
aims explore factors may predispose patients reoperation sacral neuromodulation snm methods patients enrolled longitudinal neuromodulation database reviewed medical records data voiding diaries interstitial cystitis symptom problem indices icsi overactive bladder questionnaires oab baseline months analyzed pearson chi fisher exact test wilcoxon rank tests multivariable logistic regression results patients least one reoperation median months follow range revised explanted common reason reoperation lack efficacy worsening symptoms reoperations group higher proportion women lower mean body mass index bmi reprogramming events longer median follow higher proportions interstitial cystitis using hormone replacement therapy complications reoperations reoperations groups similar improvements icsi oab severity quality life multivariate analysis longer follow complication significant predictors reoperations women using hrt time implant also predictive reoperation conclusions largest known series date one third patients required reoperation common reason lack efficacy worsening symptoms ongoing study needed technology continues evolve wiley periodicals inc
aim study determine effect saccharomyces cerevisiae morphological histochemical properties duodenum duodenal submucosal glands rabbits twenty weeks old male new zealand white rabbits obtained experimental animal laboratory uludag university bursa rabbits divided randomly two groups day first group control group received basal diet second group group received basal diet supplemented saccharomyces cerevisiae level feed duodenal tissue taken end experiment duodenum animals fixed neutral buffered formalin embedded paraffin sections stained localizing characterizing glycoproteins gps morphometric measurements study total mucosa villus heights gland depth duodenum found longer control group group however duodenal crypt depth greater duodenum control groups significant difference groups goblet cells showed similar reaction groups brunner glands similar stained pas groups however showed stronger positive reaction pas pas staining group compared control conclusion addition diet rabbits increased total mucosa villus height gland depth however addition also little affected histochemical features duodenum increased secretion neutral acidic mucins brunner glands therefore may proposed higher doses saccharomyces cerevisiae may used digestive health
study presents novel adaptive control scheme variable speed wind turbine vswt driven permanent magnet synchronous generator pmsg ensure operation different operating conditions adaptive control scheme based affine projection algorithm apa provides faster convergence less computational complexity least mean square algorithm proposed adaptive controller used control generator side converter grid side inverter without giving additional tuning efforts vector control scheme converter inverter four apa based adaptive proportional integral controllers detailed modelling control strategies system study demonstrated real wind speed data extracted hokkaido island japan used study dynamic characteristics grid connected vswt pmsg investigated details ensure proposed controller operation different operating conditions effectiveness proposed adaptive controller compared obtained using optimised controllers taguchi method validity adaptive vector control scheme verified simulation results performed using pscad emtdc environment
modern manufacturing business based product service systems require software platforms capable supporting offerings lifecycle thus securing long term customer value also function get manage feedback end users customers manufacturing essential design build functionalities features best enable efficient use maintenance aim integrate product life cycle management plm service life cycle management slm concepts resulting coherent collaborative product service design manufacturing engineering platform concept requirements collected four real world use cases refined combined create final set requirements paper present facilitated requirement collection process final requirements relation engineering collaboration product service system characteristics
aim paper develop software designing steel reinforced elastomeric isolator srei according american association state highway transportation officials load resistance factor design aashto lrfd specifications srei used almost bridge types special structures srei structures interface defines support boundary conditions may affect seismic performance bridges seismic performance bridge also affected geometrical materials properties srei selection srei complicated process includes satisfying design constraints arising code provisions maximizing performance lowest possible cost paper design stage srei described aashto lrfd aashto lrfd analysis design program srei performed different geometrical material properties created object oriented language srei cad name created software allows accurate design economical estimation srei short time determine types srei effects two different types bearings rectangular circular similar materials dimension properties selected application designs sreis completed srei cad seen ensuring stability circular elastomer bearing service limit state generally complicated rectangular bearing
play development part child growth maturation process since birth games general technologically augmented games particular play fundamental role process paper introduces design implementation deployment new version popular tower game integrated within ambient intelligence ami simulation space based knowledge stemming processes theories used occupational therapy augmented interactive table three dimensional avatar employed order extend purpose objectives game applicability expands age group preschool children years old various augmented artifacts force pressure sensitive interactive surface augmented pen digital dice integrated environment aiming enhance children play experience augmented artifacts game becomes capable monitoring following progress young player adapt accordingly provide important information regarding abilities skills child development growth progress time
unique position topologically central role densely interconnected brain hubs study aimed investigate whether regions related connections would particularly vulnerable migraine study explored rich club structure role global functional dynamics patients migraine without aura healthy controls dti resting fmri used construct structural connectivity functional connectivity networks independent replication data set patients controls included replicate validate significant findings compared controls structural networks patients exhibited altered rich club organization higher level feeder connection density abnormal small world organization increased global efficiency decreased strength coupling abnormal topological properties headache attack duration exhibited significant association increased density feeder connections results indicated migraine may characterized selective alteration structural connectivity rich club regions tending higher bridgeness non rich club regions may increase integration among pain related brain circuits excitability less inhibition modulation migraine
sociology students well prepared think critically inequalities involving race gender social class sexuality topics body weight health present challenges classroom discussion primarily due body status contemporary society simultaneously malleable able changed intractable indicator moral worth associations lead cases size discrimination often called sizeism impacts similar experienced around race gender discrimination challenge students taken granted assumptions regarding weight health detail two classroom techniques involving deconstructing obesity epidemic comparing pro ana community bodybuilders similar use extreme behaviors achieve ideal bodies way students learn critically assess something held stigmatized position fatness well something held valued position thinness
new results corrosion resistance borided cocrmo alloy exposed hanks solution different days estimated means electrochemical impedance spectroscopy technique cob cob coating developed surface borided alloy using powder pack boriding process exposure corrosion resistance borided cobalt alloy evaluated fitting suitable equivalent electrical circuits using nyquist bode plots obtain electrochemical parameters results compared cocrmo non borided alloy samples borided non borided characterized scanning electron microscopy energy dispersive ray spectrometry techniques determine elemental chemical composition developed surface materials addition reaction products formed surface borided cocrmo alloy exposed hanks solution tenth day immersion analyzed ray photoelectron spectroscopy xps technique results showed corrosion resistance borided cobalt alloy affected reduced presence crpo clusters formed material surface finally electrochemical reactions developed immersion borided cobalt alloy tenth day exposure proposed according xps results
examined effects belief pure evil bpe belief pure good bpg perceptions evaluations stereotypically altruistic egoistic hero apprehended criminal perpetrator overall participants appreciably supported formal public accolades altruistic hero greatly deified venerated altruistic hero greater levels bpg associated greater deification altruistic hero levels bpg predict support awards rewards either hero levels bpe associated deification either altruistic egoistic hero although greater levels bpe associated greater support rewarding hero individuals strongly believe rewards foster prosocial behavior ultimately characterizing others altruistic meaningfully impacts perceptions heroic behavior preexisting beliefs good evil importantly appear impact perceptions well elsevier ltd rights reserved
granular flow pebbles pebble bed reactor pbr influence gravity dense granular flow long lasting frictional contacts basic governing physics fully understood hence dynamic core pbr non idealities associated pebbles flow inside reactor core non trivial significance point view safety analyses licensing thermal hydraulics current study overall zonal pebbles residence time investigation carried implementing noninvasive radioisotope based flow visualization measurement techniques residence time distribution rtd radioactive particle tracking rpt characteristics overall pebble residence time transient number zonal residence time component average zonal velocities different initial seeding positions tracer particle summarized found overall pebbles residence time transient number increases component average zonal velocities decreases center towards reactor wall also pebbles zonal residence time results whole core divided three zones provide insight understanding pbr core dynamics reported benchmark data provided could used assessment commercial house computational methodologies related granular flow investigations elsevier ltd rights reserved
purpose applying cnga gene augmentation therapy cure novel causative mutation underlying achromatopsia achm sheep methods impaired vision spontaneously appeared newborn lambs characterized behavioral electroretinographic erg histologic techniques deep sequencing reads affected lamb unaffected lamb compared within conserved genomic regions orthologous human genes involved similar visual impairment observed nonsynonymous amino acid substitutions classified deleteriousness score putative causative mutation assessed producing compound cnga heterozygotes applying gene augmentation therapy using orthologous human cdna results behavioral assessment revealed day blindness subsequent erg examination showed attenuated photopic responses histologic immunohistochemical examination affected sheep eyes reveal degeneration cone photoreceptors expressing cnga present bioinformatics sequencing analyses suggested glyser substitution gmp binding domain cnga causative mutation confirmed genetic concordance test genetic complementation experiment five compound cnga heterozygotes carrying arg glyser mutations cnga day blind furthermore subretinal delivery intact human cnga gene using adeno associated viral vector aav restored photopic vision two affected glyser homozygous rams conclusions glyser substitution cnga identified causative mutation novel form achm awassi sheep gene augmentation therapy restored vision affected sheep novel mutation provides large animal model valid human cnga achm patients majority carry missense rather premature termination mutations
traditionally considered neuronal synchronization epilepsy caused chain reaction synaptic excitation however shown synchronous epileptiform activity may also arise without synaptic transmission order investigate respective roles synaptic interactions nonsynaptic mechanisms seizure transitions developed computational model hippocampal cells involving extracellular space realistic dynamics ions glial uptake extracellular diffusion mechanisms show network behavior fixed ionic concentrations may quite different neurons behavior detailed modeling ionic dynamics included particular show extended model strong discharge inhibitory interneurons may result long lasting accumulation extracellular sustains depolarization principal cells causes pathological discharges effect present reduced purely synaptic network results point importance nonsynaptic mechanisms transition seizure
prepared srcuo thin film radio frequency magnetron sputtering glass substrate investigated post annealing effects structure thermal conductivity sputtered film belongs two dimensional spin system srcuo namely layer type srcuo possibility exhibiting high anisotropic thermal conductivity magnetic excitation spins found sputtered film orientation spin layers parallel surface substrate post annealing results enhancement crystallinity film disappearance grain boundaries cause increase thermal conductivity ceramic society japan rights reserved
motor drives utilizing power semiconductors play important role modern day electric motor control although reliability power semiconductors widely studied product level reliability motor drives studied markedly less even though complex control measuring electronics often make vulnerable environmental stresses order advance product level accelerated reliability testing customized test methods multiple simultaneous sequential stresses used however knowledge combined effects different stresses still largely unknown research reliability commercial motor drive studied environmental conditions used included degrees constant temperature test degrees test relative humidity additionally input power interruptions included study effect sudden shortages electricity results study showed mean time failure devices tested input power interruptions notably shorter test series without especially clear effect input power interruptions seen power mosfets motor drives moreover humidity found play important role reliability motor drives
paper presents portable radar system short range localization inverse synthetic aperture radar imaging vital sign tracking proposed sensor incorporates frequency modulated continuous wave fmcw interferometry doppler modes enable radar system obtain absolute range information tiny vital signs respiration heartbeat human targets two different operation modes switched board microcontroller simplify system proposed radar utilizes audio card laptop sample baseband signal fmcw mode radar uses operational amplifierbased circuits generate analog sawtooth signal reference pulse sequence rps rps locked sawtooth signal obtain coherence radar system interferometry mode low intermediate frequency modulation method implemented avoid slow vital signs distorted high pass filter audio card several experiments carried reveal capability distinct operational features proposed portable hybrid radar experiments also showed system easily detect glass usually difficult identify optical based sensors addition scanning complex environment revealed proposed radar able differentiate human targets objects moreover isar images used isolate moving human targets surrounding clutter finally proposed radar also demonstrated ability accurately measure vital signs human subject sits still
definitions violence vary almost always operationalized researcher perceptions violence often determine levels tolerance violence little research focused lay definitions total swedes children teenagers younger adults adults male interviewed using specially developed interview protocol content analysis used assign definitional categories folk taxonomy emerged immediate physical violence accounted assigned categories hit word occurred frequently global physical violence included physical violence accounted assigned categories immediate non physical violence accounted vicarious violence including media violence accounted distributions categories respondents gender age participant role incidents violence showed underlying definitions violence extremely stable conclusion ordinary swedes share robust lay definition violence behavior immediate done close quarters physical
paper presents high speed krpm surface mounted permanent magnet smpm motor compressor applications design procedure using finite element analysis fea presented particular focus efficiency calculation paper also aims give general indications provide cost efficient solution prototype built experimental results given compared simulations
currently prognostication primary myelofibrosis pmf relies international prognostic scoring system ipss dynamic ipss dipss dipss plus incorporate age blood counts constitutional symptoms circulating blasts red cell transfusion need karyotype although jak mutation discovered decade ago mpl mutations shortly thereafter recent discovery calr mutations vast majority jak mpl unmutated patients recognition powerful impact calr mutations triple negative jak mpl calr negative status outcome set stage revision traditional prognostic models include molecular information additionally advent next generation sequencing identified host previously unrecognized somatic mutations across hematologic malignancies myelodysplastic syndromes majority common prognostically informative mutations pmf affect epigenetic regulation mrna splicing thus need arisen incorporate mutational information genes asxl srsf risk stratification systems mutations yet genes appear important players leukemic transformation new insights disease pathogenesis emerging finally number prognostically detrimental mutations may affect survival response ruxolitinib significant implications clinical decision making review briefly summarize prognostic models use today discuss detail somatic mutations commonly encountered patients pmf along prognostic implications role leukemic transformation emerging prognostic models incorporate new molecular information existing systems exclude clinical variables also presented elsevier inc rights reserved
electric trend almost corners automotive industry trend followed maritime transportation industry well result conventional mechanical transmission based propulsion systems gradually overtaken electric power transmission based propulsion systems azimuth thruster driven electric motor common configuration found modern electric propulsion systems due tight speed control stiff drivetrain propulsion systems load transients easily get propagated link motor drive subsequently upstream power bus well transients cause disturbances loads connected power system worst case stability shipboard power system gets affected transients paper proposes use capacitor clamped inverter based motor drive absorb transients thereby prevent propagation power bus efficacy proposed concept verified computer simulations simulation results show capacitor clamped inverter capable absorbing load transients without passing upstream power bus
purpose purpose paper evaluate improvement mechanical thermal properties cured epoxy modified amine functional chloroaniline formaldehyde condensate afcfc determine optimum level modification design methodology approach evaluate toughening different compositions made adding various concentration afcfc epoxy impact adhesive tensile flexural strengths modified unmodified epoxy characterised dynamic mechanical analysis thermogravimetric properties modified epoxy also reported findings modification epoxy resin using afcfc showed significant enhancement mechanical strength unmodified epoxy reason behind initial stage curing afcfc miscible epoxy form homogeneous solution homogeneity promotes chemical reaction network formation curing process molecular weight increases component separates within reaction medium form second dispersed phase research limitations implications toughening agent afcfc synthesised using chloroaniline formaldehyde changing amine aldehyde toughening agents could synthesised efficiency modification epoxy resin using could also studied originality value afcfc modified epoxy could used field coating casting adhesives potting encapsulation semiconductor devices
neurodegenerative diseases characterized progressive degeneration neurons central peripheral nervous system cns pns resulting reduced innervation target structures loss function shared characteristic many neurodegenerative diseases infiltration microglial cells affected brain regions early disease stages microglial cells often display rather neuroprotective phenotype switch pro inflammatory neurotoxic phenotype later stages disease contributing neurodegeneration activation rho kinase rock pathway appears instrumental modulation microglial phenotype increased rock activity microglia mediates mechanisms inflammatory response associated improved motility increased production reactive oxygen species ros release inflammatory cytokines recently several studies suggested inhibition rock signaling promising treatment option neurodegenerative diseases review article discuss contribution microglial activity phenotype switch pathophysiology parkinson disease amyotrophic lateral sclerosis als two devastating neurodegenerative diseases without disease modifying treatment options furthermore describe rock inhibition influence microglial phenotype disease models explore rock inhibition future treatment option als
two targets presented within approximately context rapid serial visual presentation rsvp participants ability report second target reduced compared targets presented apart time phenomenon known attentional blink increased magnitude first target emotionally arousing emotionally arousing stimuli also capture attention create like effect even stimuli presented ignored distractor items single target rsvp task phenomenon known emotion induced blindness eib phenomenological similarity behavioral results associated emotional eib suggest effects may result similar underlying mechanisms hypothesis tested using event related electrical brain potentials erps behavioral results replicated reported previously demonstrating enhanced following emotionally arousing target clear eib effect paradigms highly arousing taboo sexual words resulted increased early posterior negativity epn component suggested represent early semantic activation selection processing working memory paradigms taboo sexual words also produced increased late positive potential lpp component suggested represent consolidation stimulus working memory therefore erp results provide evidence eib emotion enhanced effects share common underlying mechanism
due increasing complexity software development activities need effective effort estimation techniques arisen underestimation leads disruption project estimated cost delivery hand overestimation causes outbidding financial losses business effective software effort estimation techniques enable project managers schedule software life cycle activities appropriately correctly assessing effort needed develop software product major concern software industries random forest technique popularly used machine learning technique helps improving prediction values main objective study precisely assess software projects development effort utilising use case point approach effort parameters optimised utilising technique acquire higher prediction accuracy moreover results acquired applying technique compared multi layer perceptron radial basis function network stochastic gradient boosting log linear regression techniques highlight performance attained technique
migration towards digital control systems creates new security threats endanger safety industrial infrastructures addressing convergence safety security concerns context provide comprehensive survey existing approaches industrial facility design risk assessment consider safety security also provide comparative analysis different approaches identified literature elsevier ltd rights reserved
sample chinese studied observed greater disc degeneration mri associated greater spine dxa bmd yet association may confounded facet joint osteoarthritis bmd may risk factor lumbar disc degeneration chinese purpose evidence suggested lumbar vertebral bone intervertebral disc interact multiple ways current paper aims determine association bone mineral density bmd lumbar disc degeneration using sample chinese methods studied patients back disorders general subjects china subjects lumbar spine magnetic resonance imaging dual energy ray absorptiometry dxa spine bmd studies subset general subjects additional hip bmd measurements weighted images pfirrmann score used evaluate degree lumbar disc degeneration facet joint osteoarthritis assessed none slight moderate severe regression analyses used examine associations lumbar hip bmd disc degeneration adjusting age gender body mass index bmi lumbar region facet joint osteoarthritis results greater facet joint osteoarthritis associated greater spine bmd hip bmd disc degeneration general subjects conclusion bmd may risk factor lumbar disc degeneration chinese facet joint osteoarthritis inflates dxa spine bmd measurements therefore may confound association spine bmd disc degeneration
objective estimate effect increased body weight body mass index bmi pregnancy rates levonorgestrel lng used emergency contraception methods study reviewed data women four hrp randomized trials conducted participants took either lng single dose two doses apart unprotected intercourse contraceptive efficacy pregnancy rates different weight bmi categories evaluated results overall pregnancy rate low pregnancy rates also low women weighing obese bmi pooled analyses pregnancy demonstrated bmi decreased efficacy significantly odds ratio confidence interval compared women lower bmi categories mainly influenced pregnancies obese women one study site sensitivity analyses excluding site showed obesity longer risk factor however studies included obese women sample exclude substantial decrease efficacy conclusions pregnancy rates use lng low less across different weight bmi categories pooled analyses showed increase pregnancy rates among obese women bmi compared women normal bmi levels influenced pregnancies coming one study site published elsevier inc
paper proposes new approach systematic synthesis active inductors via signal flow graphs sfgs basic idea consists proposing using sfg stamps active basic building blocks abbs construct equivalent sfg classical inductor show large number active inductors thus synthesized twelve proposed novel known abbs well newly proposed ones used namely current conveyors operational transconductance amplifiers ota current conveyor transconductance amplifiers ccii current feedback operational amplifiers cfoa operational transresistance amplifiers otra current backward transconductance amplifiers cbta current feedback transconductance amplifiers cfta voltage differencing inverting buffered amplifiers vdiba spice simulations given show viability proposed technique elsevier ltd rights reserved
disseminated fusariosis rare disease data scant pediatric patients fungiscope registry identified children disseminated fusariosis analysis largest pediatric case series reported date adds pediatric specific experience management opportunistic infection children
objective paper present fusion model odor sensor highly advanced optical sensor evaluate total volatile basic nitrogen tvb content chicken meat aroma odor data variables obtained odor sensor colorimetric sensor spectral well textural data variables obtained optical sensor hsi fused together data processing odor variables obtained via low level data abstraction lla simply concatenated texture feature variables obtained middle intermediate level data abstraction ila totaling variables dataset approach multiple level data fusion mlf produced better pca bpann prediction results either individual system higher lower rmsep along increased calibration model efficacy furthermore prediction level escalated rmsep data fusion technique improved applying pearson correlation analysis uncorrelated data variables removed dataset statistical level significance step reduced data variables original information therefore results highly encourage multiple sensor fusion improved mlf technique better model performance evaluate chicken meat freshness published elsevier
olympic games one popular global mega media events however ways opening olympic games london reported varied significantly one country another order compare different countries represented event conducted qualitative discourse analysis three days television news coverage channels five countries united states china japan germany united kingdom explored whether different locations political systems television systems affect event reported found european public service broadcasters bbc ard serious critical political commercial counterparts itv rtl japanese commercial broadcaster coverage event critical public service broadcaster popularized nationalistic throughout china market oriented dragon evaluative reporting state run cctv nbc monopolized broadcast rights united states emphasized universal values olympics avoided nationalism light results future attention directed toward role commercial broadcasting contemporary globalized world ideological constellations changing
rationalize driving factors competition halogen bonding hydrogen bonding complexes combined halogen hydrogen bond donor difluoroiodomethane lewis bases trimethylphosphine dimethyl sulfide chloromethane studied lewis bases initio calculations lead halogen hydrogen bonded complexes fourier transform experiments involving solutions mixtures difluoroiodomethane trimethylphosphine dimethyl sulfide liquid krypton confirm coexistence halogen bonded hydrogen bonded complex also solutions containing chloromethane evidence formation binary associations found definitive assignment multiple complex bands could made using van hoff plots experimental complexation enthalpies halogen hydrogen bonded complex difluoroiodomethane trimethylphosphine determined mol respectively halogen hydrogen bonded complexes dimethyl sulfide values mol respectively experimental observation trimethylphospine dimethyl sulfide halogen bonded complex stable hydrogenbonded complex supports finding softer lewis bases tend favor iodine halogen bonding hydrogen bonding
model predict motor temperature electrical submersible pump esp variable conditions flow rate loading developed model takes account coupled behavior motor pump production system thus given defined frequency variable speed drive motor temperature determined result equilibrium heat generation calculated power pump demands motor heat extraction resistance calculated production flow rate around motor furthermore real field operations measurement motor temperature made lower end stator winding exactly maximum temperature point order predict maximum motor temperature value model developed work determines motor temperature distribution convective heat transfer study also made comparing models based fully developed temperature profile models consider development thermal boundary layer case study made several oil viscosities water cut results showed fact commonly observed esp field operations motor temperature rises motor speed continuously increased also shown neglecting effect thermal boundary layer development may result overheated motor prediction actually motor maximum temperature much lower upper limit thus observed fully developed temperature profile models suffer inaccuracy used viscous oil applications great thermal entry length elsevier rights reserved
patients type diabetes mellitus tdm traditionally low body mass index microangiopathic complications common diabetes control complications trial published demonstrated therapy aimed maintaining hbac levels close normal feasible reduced incidence microangiopathy since use intensive insulin therapy optimise metabolic control became generalised two main side effects higher rate severe hypoglycaemia increased weight gain approximately patients tdm currently obese overweight reduces nullifies benefits good metabolic control negative consequences therefore strategies achieve weight control patients tdm necessary present treatment glp sglt inhibitors yielded promising short term results need confirmed studies larger numbers patients long term follow possible coming years applicability bariatric surgery obese patients tdm similar general population tdm
purpose sought evaluate patient adherence response simple vaginal sexual health treatment strategies female cancer patients receiving treatment female sexual medicine health program identify improvements physical symptoms per patient clinical evaluation method evaluability criteria included gynecologic exam initial visit least one follow gynecologic exam within months initial visit consecutive follow ups declined time vas scores improved last assessment vuas scores sexual function scores significantly improved confidence future sexual activity increased sexual vaginal health concerns decreased conclusion significant changes observed women using treatment strategies improvement vulvovaginal symptoms decrease elevated vaginal pain exams enhanced sexual function increased intimacy confidence implication findings high clinical relevance symptom management improvement sexual function using simple strategies clinical tools oncology setting
although problem area coverage intensively investigated dense wireless sensor networks wsns arrive coverage sensor deployment optimizes certain objectives relatively sparse wsns still faces theoretical practical difficulties moreover handful centralized algorithms proposed elevate area coverage surface coverage paper present practical algorithm autonomous deployment load balancing surface coverage apollo move sensor nodes toward surface coverage aiming minimizing maximum sensing range required nodes apollo enables purely autonomous node deployment entails localized computations prove termination algorithm local optimality output also show optimization objective closely related frequently considered objectives area coverage therefore practical algorithm design also contributes theoretical understanding area coverage problem finally use extensive simulation results confirm theoretical claims demonstrate efficacy apollo
field study indoor thermal environment pollutants conducted households years old children changsha south central city china aim identify examine main indoor pollutants affect schoolchildren health households divided two groups group households apparently unhealthy children group households healthy children findings autumn winter indicated differences temperature relative humidity groups significant average concentrations hcho acetaldehyde group lower group however average concentrations tvocs group higher group addition indoor concentrations ten households exceeded upper limit chinese national standard tvocs concentration two households exceeded upper limit winter average concentrations ethylhexyl phthalate dehp dibutyl phthalate dbp could harm children health significantly higher group household group cladosporium aspergillus penicillium indoor air house dust could lead children allergy respiratory diseases correlated seasonal climate variation found high level indoor tvocs dehp dbp house dust possibly main risk factors children health cladosporium aspergillus penicillium possibly providing associated health risks elsevier ltd rights reserved
present package mnlogit estimating multinomial logistic regression models particularly involving large number categories variables compared existing software mnlogit offers speedups times modestly sized problems times larger problems running parallel mode multicore machine gives times additional speedup processor cores mnlogit achieves computational efficiency drastically speeding computation log likelihood function hessian matrix exploiting structure matrices arise intermediate calculations efficient exploitation intermediate data structures allows mnlogit utilize system memory much efficiently applications mnlogit requires less memory comparable software factor proportional number model categories
advent native mobile technologies particularly advances mobile operating systems popularly among android windows mobile ios acceptance alternative existing browser based access enabled remote access equipment instruments world wide web www remote control solutions implemented industry via local area networks lans wide area networks wans web online remote accessible laboratory oral surpassed simulation tool learning scientific methods results observations real time rather ideal facilitate conduct experiments specific instrumentation location aim paper introduce easy accessible remote laboratory measuring system rlms provide students perform laboratory experiments actual measurement instrumentation smart mobile device tablets desktops pcs proposed architecture real laboratory setup provides solutions remote access opens ways future developments system realized using labview graphical programming environment confers advantages
perspective science based innovation study introduces measures scientific linkage technology science correlation index technological innovation capabilities relative growth rate relative patent position revealed technological advantage compare analyze international competitiveness solar energy technologies among united states european union japan china south korea based solar energy technologies related patents european patent office worldwide patent statistical database making international comparisons technological development innovation paradigm find different innovation characteristics various technology fields within solar energy industry propose relevant policy recommendations latecomers implement catch strategies results show leading countries regions solar energy industry united states european union focus mainly science based innovation japan latecomers like china south korea pay attention technology based innovation addition two fields within solar energy industry present opposite innovation characteristics solar photovoltaic technologies especially thin film organic cells present strong technological innovation capabilities high scientific linkage solar thermal technologies show strong technological innovation capabilities low scientific linkage
objective noninvasive diagnostics early stages coronary artery disease discrimination various extents vascular lesions patients important clinical problem especially considering wide spread use cholesterol lowering drugs affect lipid lipoprotein profiling main goal study evaluate applicability new combinations noninvasive biomarkers leptin insulin adiponectin endothelin ratios detection early stages coronary atherosclerosis versus later stages disease patients methods number previously validated serum biomarkers tested group patients coronary artery disease examined association severity coronary lesion according gensini score determined coronary angiography results lowest extent coronary lesions associated significant increase apoa levels significantly increased ratios adiponectin endothelin leptin insulin male female patients adiponectin endothelin ratio associated gensini score representing early high coronary lesions female male patients leptin insulin ratio associated gensini score representing early high coronary lesions conclusion leptin insulin adiponectin endothelin ratios novel derived biomarkers useful noninvasive diagnostics initial stages coronary lesions patients coronary artery disease
analytic hierarchy process ahp approach widely applied multiattribute decision making situations since introduced believed ahp appropriate assist decision making problems characterized number interrelated factors recently derivative ahp called fuzzy ahp developed mixing ahp fuzzy set theory new method increasingly extends application areas construction management despite extensive use fuzzy ahp little research conducted comparability calculated priority weight vectors fuzzy ahp traditional ahp therefore paper mainly focuses comparison two ahp approaches investigating weight vectors produced real case study previous studies four different fuzzy ahp approaches prepared applying different fuzzy fundamental scales weight aggregations tested identify method produces comparable results traditional ahp main findings results obtained four approaches presented discussed detail american society civil engineers
high speed machining highly effective production method achieve following goals increased machining productivity enhanced quality machined surface improved machining economy improved ecological impact machining objective research study technological factors influence surface roughness parameters high speed milling two different types die steel factors analysed feed rate overlap strategy depth cut cutting speed kept constant article based technological experiment performed department mechanical materials engineering polytechnic university valencia measurements surface topography mechanical engineering institute riga technical university
radical right political parties usually heavily male dominated accordingly previous research concentrated perspective men present study aims enhance understanding worldview women within radical right parties taking critical discursive psychological approach study looks female populist radical right politicians sweden finland discursively negotiate tension nordic societal norm gender equality one hand patriarchal ideology populist radical right parties analysis suggests female populist radical right politicians discourse indeed highly ambivalent discursive tension gender equality patriarchal politics heavily intertwined two tensions first societal norm prejudice versus politics based xenophobia second culture cherishes individualism versus political pressure homogenize political cultural study compares discourse female populist radical right politicians two country contexts moreover discusses differences similarities discourse one hand male populist radical right politicians finally analyses gendered racialized categorizations accomplished discursive patterns elaborates societal implications
beneficial influence sleep memory consolidation well established however mechanisms sleep dynamically consolidate new memories existing networks continued environmental adaptation individual unclear role sleep complex associative memory emerging field literature yet systematically reviewed systematically review published literature role sleep complex associative memory processing determine reasonable published evidence support active role sleep facilitating complex associative processes rule gist extraction false memory determine sleep physiological events states impact processes quantify strength relationships meta analysis twenty seven studies healthy adults identified combined indicate moderate effect sleep facilitating associative memory tested behaviourally studies measured sleep physiology reported mixed findings significant associations sleep electrophysiology outcome appear based largely mode acquisition interpret findings supporting reactivation based models associative processing elsevier ltd rights reserved
svd algorithm successfully utilized adaptively learning sparse dictionary seismic denoising high computational cost many singular value decompositions svds svd algorithm applicable practical situations especially problems paper extend dictionary learning based denoising approach address computational efficiency problem svd propose fast dictionary learning approach based sequential generalized means sgk algorithm denoising multidimensional seismic data sgk algorithm updates dictionary atom taking arithmetic average several training signals instead calculating svd used svd algorithm summarize sparse dictionary learning algorithm using svd introduce sgk algorithm together detailed mathematical implications synthetic field data examples used demonstrate performance svd sgk algorithms shown sgk algorithm significantly increase computational efficiency slightly degrading denoising performance
survival outcomes hospital cardiac arrest ohca provided emergency medical services ems without doctor board objective determine outcomes whole country public physician led ems methods analyzed data nationwide prospective registry ohca cases attended public ems spain covering period october october dispatch center patients receiving als men patients return spontaneous circulation hospital arrival initial rhythm shockable hospital discharge good neurological status cpc found study population considering utstein comparator group patients total patients arrived hospital ongoing resuscitation one survived cpc patients included non heart beating donation programs conclusions spain physician led ems ohca survival cpc reached reasonable percentage despite modest contribution bystander bls ongoing resuscitation strategy seems futile except considering non heart beating donation programs elsevier rights reserved
one methods obtaining curve surface complex shape engineering geometry computer graphics including area computer vision multi view geometry multi view stereo reconstruction chaikin algorithm suggested unfortunately algorithm works broken lines step get continuous smooth curve surface current article paper work aims generalize known engineering geometry chaikin algorithm modeling curves surfaces arbitrary smoothness class proved chaikin algorithm special case wavelet recovery spline curve spline surface smoothness class using filterbank constructed basis splines arbitrary order spline wavelets suggested generalization chaikin algorithm modeling curves surfaces arbitrary smoothness class generalized chaikin algorithm proposed set theoretical tools computer aided design computer vision systems
paper proposed exp phi method establish hyperbolic trigonometric rational function solutions fractional differential equations sense modified riemann liouville derivative illustrate validity method solve time fractional sharma tasso olver dimensional time fractional korteweg devries zakharov kuznetsov kdv equations type method newly submitted literature construct exact solutions nonlinear fractional differential equations nfdes elsevier gmbh rights reserved
two biodegradable non toxic cationic gemini surfactants ester linkage spacer namely cmhm chcooch cmh synthesized characterized using elemental analysis nmr corrosion inhibition performance synthesized compounds separately combination sodium salicylate along nature stability inhibitive film mild steel solution degrees evaluated using weight loss potentiodynamic polarization eis visible spectroscopy ftir sem edax tga quantum chemical calculations results studies confirm effective corrosion inhibitor hci inhibition effect synergistically strengthened presence synthesized compounds act mixed type inhibitor adsorb surface accordance langmuir adsorption isotherm experimentally measured inhibition efficiencies correlated molecular parameters obtained using semi empirical method empirical results good agreement theoretical predictions elsevier rights reserved
one major challenges related teaching programming algorithmics amateur students time spent explain language syntax also students undertake computer programming may find problems hinder understanding concepts development problem solving programming skills paper presents results experimental approach evaluated interaction group colombian students web solution within context mobile robotics learn programming algorithmics designed web app oriented towards autodidactic learning using visual blocks programming five interactive modules include concepts learned students following variables sensors conditionals cycles functions solution designed present virtual scenarios mobile robotics proposal evaluated middle school students colombian education system compared results obtained using scratch reference tool
bipolar disorder fundamentally disorder emotion regulation associated explicit processing biases socially relevant emotional information human faces less known however whether implicit processing type emotional information directly influences social perception thus investigated group related differences influence unconscious emotional processing conscious person perception judgments using continuous flash suppression task among individuals remitted bipolar disorder age age female compared healthy adults ctl age age female across groups participants rated neutral faces trustworthy warm competent paired unseen happy faces compared unseen angry neutral faces participants rated neutral faces less trustworthy warm competent paired unseen angry compared neutral faces findings suggest emotion related disturbances explained early automatic processing stages activity dorsal visual stream underlying implicit emotion processing intact bipolar disorder implications understanding etiology emotion disturbance discussed elsevier rights reserved
impairment physical performance might identify older people higher risk dementia time present study evaluated handgrip strength independent predictor cognitive decline observational prospective follow duration months geriatric outpatients center consecutive stroke dementia free older adults men ages years clinical dementia rating scale clock drawing test cdt administered handgrip strength assessed using jamar hand dynamometer brain magnetic resonance imaging studies performed white matter damage expressed severity white matter hyperintensities wmhs longitudinal changes cognitive function expressed year decline cdt performance robust association observed baseline handgrip strength year cognitive decline multiple adjustment note strength association minimally attenuated adjusting deep wmhs extent beta coefficient handgrip strength handgrip strength predicted accelerated year decline cognitive function assessed cdt sample older adults future studies needed elucidate causal mechanisms linking limitations physical function dementia risk
light therapy widely used treatment seasonal affective disorder recently evidence indicated may play role bipolar depression either monotherapy combination total sleep deprivation tsd however studies examining treatment effect bipolar depression resulted inconsistent findings clarify role disorder conducted meta analysis compare efficacy treatment bipolar depression results individual studies synthesized random effects model nine studies including patients bipolar depression included current meta analysis found disease severity significantly decreased without tsd concomitant medication augmentation treatment significantly decreased disease severity compared treatment without results highlight significant efficacy either monotherapy combination tsd treatment bipolar depression however detailed mechanism still remains elusive well designed controlled trials required investigate optimal intensity frequency treatment bipolar depression elsevier ecnp rights reserved
introduce first principles analysis information content multivariate distributions information sources specifically generalize balance equation visualization device entropy triangle multivariate distributions find notable differences similar analyses done joint distributions models information channels example application extend framework analysis classifiers also encompass analysis data sets tools analyze handful uci machine learning task start addressing question well datasets convey information supposed capture phenomena stand elsevier ltd rights reserved
malignant melanoma highly aggressive neoplasia melanocytic origin part lack effective treatment methods incidence mortality rates disease continue increase rapidly accumulating evidence suggests dysregulation epigenetic mechanisms including dna methylation demethylation chromatin modification remodeling diverse activities noncoding rnas play central role pathogenesis melanoma epigenetic mark hydroxymethylcytosine hmc attracted interest since shown ten eleven translocation proteins enzymatically convert methylcytosine hmc key intermediate dna demethylation factors regulate dna hydroxymethylation frequently altered cancer leading deregulation hmc levels review discuss relationship melanoma dna hydroxymethylation regulation dna hydroxymethylation defects pathway melanoma copyright wolters kluwer health inc rights reserved
response concerns hazardous chemicals children products washington state passed children safe product act cspa cspa requires manufacturers report concentration chemicals children products describe framework toxicological prioritization ten chemical groups frequently reported cspa framework scores lifestage exposure duration primary secondary tertiary exposure routes toxicokinetics chemical properties calculate exposure score four toxicological endpoints assessed based curated national international databases reproductive developmental toxicity endocrine disruption neurotoxicity carcinogenicity total priority index calculated product toxicity exposure scores three highest priority chemicals formaldehyde dibutyl phthalate styrene elements framework compared existing prioritization tools united states environmental protection agency epa expocast toxicological prioritization index toxpi cspa framework allowed examine toxicity exposure pathways lifestage specific manner providing relatively high throughput approach prioritizing hazardous chemicals found children products
recent times additional pathways involved regulation myometrium suggested also holds true effect drugs oxytocin adrenergic agonists myometrium knowledge additional pathways certainly prove useful designing better therapies pathologies myometrium study therefore aimed investigating possibility pathways involved activities ritodrine rit adrenergic agonist myometrium utilizing metabolomics bioinformatics high resolution fourier transform mass spectrometry hrftms nuclear magnetic resonance nmr spectroscopy coupled functional uterine assays used innovative assessment vitro pharmacological assay nmol rit nmol isolated mice uteri mounted organ baths performed mice uteri treated rit well physiological buffer uterine tissues immersed rapidly collected analyzed using hrftms proton nmr bioinformatics resulting data analyzed via pairwise chemometric comparison models considered statistically significant addition previously known metabolites nicotinamide adenine dinucleotide aminobutyric acid sphingosine significantly associated activity whereas activity rit associated downstream involvement prostaglandin phosphatidylinositol signaling findings add evidence reports additional regulation myometrial activity drugs suggest newer pathways therapeutic manipulation
aim experimental research flat objects recognition linear discriminant analysis using dimensionless signs contours binary images determining possibility applying method computer vision systems published elsevier
since cost rare earth permanent magnets pms ndfeb smco increasing great interest designing machines without adopting rare earth pms replacing cheaper ferrite magnets referring interior ipm machines expected performance reduction limited owing anisotropic structure reluctance rel torque component compensates use low energy pms paper investigates convenience adopting ferrite magnets ipm machine sometimes also referred assisted synchronous rel machine instead rare earth surface mounted machine shown even though lengthening stack length required anisotropic machine adopts ferrite magnets may represent valid competitor surface machine rare earth pms
background recent reports call reductions costly potentially avoidable services emergency department visits providing high quality safe care oncology patients remains challenging providers given diversity patients seeking care unpredictable clinical environment use oncology patients appropriate acute health concerns visits may preventable well coordinated care adequate symptom management objective aim study summarize available evidence regarding incidence predictors reasons visits among oncology patients methods keyword mesh term searches conducted using online databases inclusion criteria publication date april december sample size report incidence predictors use among oncology patients results studies met criteria varied study aim design time frames calculating utilization rates incidence visits among oncology patients ranged day standardized visit rate incidence ranged collectively studies lack population based estimates cancers combined conclusions studies included review suggest rates use among cancer patients exceed general population however extent use oncology patients reasons visits remain understudied implications practice nurses involved treatment cancer patient education symptom management nurses well positioned develop patient centered treatment care coordination plans improve quality care reduce visits
paper proposed various methods extract parasitic capacitance components nanowire fet using technology computer aided design tcad simulation first parasitic capacitance components extracted ideal method using structure without spacer extracted results calculated values almost identical next non ideal methods varying spacer length dielectric constant spacer used extract parasitic capacitance components method using spacer length accompanies structural change relatively large error occurred extracting outer fringing capacitances however method varying dielectric constant spacer structural change method showed much smaller error method varying spacer length also found show almost results extracted ideal method
paper explores gender differences personality disorder traits clinical syndromes among parental competency examinees examinees completed mcmi iii wais iii male examinees obtained higher scores females although low average range ability males significantly higher social desirability scores lower debasement scores multivariate analysis variance carried clinical personality patterns clinical scales controlling validity indices significant main effects clinical personality patterns clinical scales medium effect size univariate analysis showed males significantly higher scores antisocial sadistic narcissistic alcohol drug misuse scales results found male female parental competency examinees homogenous group rather two distinct groups different personality profiles differing levels intellectual ability implications future parental competency assessments discussed elsevier ltd rights reserved
provide overview selected crypto hardware devices special reference lightweight electronic implementation encryption decryption schemes hash functions true random number generators detail discuss hardware implementation chief algorithms used private key cryptography public key cryptography hash functions discussing important security issues electronic crypto devices related side channel attacks scas fault injection attacks corresponding design countermeasures taken finally present overview hardware implementation true random number generators discussing chief electronic sources randomness types post processing techniques used improve statistical characteristics generated random sequences copyright john wiley sons ltd
computer aided materials design process highly iterative nature requires flexible tools ability link processing properties performance usual forward direction also inverse direction associated goal oriented design framework integrated computational materials engineering icme many computational techniques exist relate properties performance forward inverse directions tools prescribe process given desired microstructure developed detail research fills gap coupling physics based precipitation models mesh adaptive direct search optimization techniques strategy develop inverse microstructure processing relations framework demonstrated prescribing heat treatments rich niti shape memory alloys result desired size distribution precipitates prescriptive technique provides rigorous strategy identification materials processing schedules provided forward models connecting processing microstructure available yield specific microstructural features significantly reduce experimental search space needs explored accelerating materials development process elsevier ltd rights reserved
last decades exp function method used solving fractional differential equations paper obtain exact solutions fractional generalized reaction duffing model nonlinear fractional diffusion reaction equation fractional derivatives described modified riemann liouville sense fractional complex transform suggested convert fractional order differential equations modified riemann liouville derivatives integer order differential equations reduced equations solved symbolic computation
paper seeks demonstrate protagonist carlo collodi adventures pinocchio illustrates numerous autistic phenomena communication difficulties sensory perceptual distortions mindblindness pinocchio viewed literary construct contraindications autism argued autistic traits sufficient suggest possibility collodi partial intuition syndrome years identified leo kanner approaching collodi text manner taken opportunity survey reflect upon psychoanalytic literature autism position relation contemporary theories cognitive neuroscience
background cigarette smoking established major risk factor chronic kidney disease ckd development people diabetes conflicting evidence exists among representative community based studies whether smoking independent risk factor ckd aim meta analysis assess effects tobacco smoking development ckd adult general populations methods literature search conducted using medline embase inception may prospective cohort studies reported relative risks ckd smoking status general population summary relative risks srrs confidence intervals cis calculated using randomeffects model results total prospective cohort studies including incident ckd cases included compared never smokers srrs incident ckd ever smokers current smokers former smokers srrs end stage renal disease development ever smokers former smokers current smokers considerable heterogeneity observed among studies combining additional three prospective cohort studies involved incident proteinuria cases null smoking proteinuria association general population observed conclusions meta analysis suggests evidence cigarette smoking independent risk factor incident ckd future studies required investigate whether smoking cessation decrease incident ckd general adult population
important regulator pollutants overland flow interflow land use become essential research component determining relationships surface water quality pollution sources study investigated use ordinary least squares ols geographically weighted regression gwr models identify impact land use population density surface water quality wen rui tang river watershed eastern china manual variable excluding selecting method explored resolve multicollinearity issues standard regression coefficient analysis coupled cluster analysis introduced determine variable greatest influence water quality results showed impact land use water quality varied spatial seasonal scales positive negative effects certain land use indicators found different subcatchments urban land dominant factor influencing chemical oxygen demand cod highly urbanized regions relationship weak pollutants mainly point sources agricultural land primary factor influencing suburban rural areas relationship strong pollutants mainly agricultural surface runoff subcatchments located suburban areas identified urban land primary influencing factor wet season agricultural land identified prevalent influencing factor dry season adjusted values ols models using manual variable excluding selecting method averaged higher using stepwise multiple linear regressions however corresponding gwr models adjusted similar higher optimal ols models confirming gwr models demonstrated better prediction accuracy based findings water resource protection policies consider site specific land use conditions within watershed optimize mitigation strategies contrasting land use characteristics seasonal variations elsevier rights reserved
dysfunction many ciliary proteins linked list diseases cystic kidney obesity hypertension mental retardation previously proposed primary cilia unique communication organelles function microsensory compartments house mechanosensory molecules report primary cilia exhibit membrane swellings ciliary bulbs based unique ultrastructure motility could mechanically regulated fluid shear stress together ultrastructure analysis swelling contains monosialodihexosylganglioside results show ciliary bulb distinctive set functional proteins including synthase gms bicaudal bicc polycystin fact results cilia isolation demonstrated first time gms bicc members primary cilia proteins although proteins required ciliary membrane swelling formation static condition fluid shear stress induced swelling formation partially modulated gms therefore propose ciliary bulb exhibits sensory function within mechano ciliary structure overall studies provided important step towards understanding ciliary bulb function structure
objective study assess effect silica nano filler particle diameters computer aided design manufacturing cad cam composite resin block physical properties multi scale silico cad cam blocks modeled consisting silica nano filler particles matrix bis gma tegdma filler volume contents calculation young moduli poisson ratios block macro scale analyzed homogenization macro scale cad cam blocks xxmm modeled compressive strengths defined fracture loads exceeded mps values nano scale models compared localization analysis filler size decreased young moduli compressive strength increased poisson ratios mps decreased parameters significantly correlated diameters filler particles pearson correlation test silico multi scale model established study demonstrates young moduli poisson ratios compressive strengths cad cam blocks enhanced loading silica nanofiller particles smaller diameter cad cam blocks using smaller silica nano filler particles potential increase fracture resistance
structured query language sql widely used operate relational databases rdbs operate rdb sql application called sql client used recently many sql clients developed become users friendly sql client useful learning sql designed classroom problems associated classroom use one problem teacher monitor learner progress case difficult add function sql client paper propose method gathering information monitoring study progress rdb side using audit log method learners use sql client developed experimental system implement method evaluate use classroom authors published elsevier open access article license http creativecommons org licenses peer review responsibility kes international
objectives describe national patterns chronic rhinosinusitis crs care across academic community practices determine prevalence comorbid disorders crs patients including nasal polyposis allergic rhinitis asthma cystic fibrosis identify demographic clinical practice type factors associated endoscopic sinus surgery ess study design multisite cross sectional study setting otolaryngology national research network cheer creating healthcare excellence education research subjects methods total adult patients crs identified seen community practices sites academic practices sites multivariate logistic regression used evaluate association demographic practice type clinical factors odds patient undergoing ess results average age years patients female caucasian prevalence comorbid diseases follows allergic rhinitis nasal polyposis asthma cystic fibrosis addition patients academic centers underwent ess compared community sites multivariate analyses nasal polyposis odds ratio cystic fibrosis academic site type associated ess adjusting factors conclusions describe practice patterns crs care well demographic clinical factors associated ess first study practice patterns crs utilizing cheer network may used guide future research
adriatic ionian macro region one four mediterranean sub regions recorded approximately million cruise passengers million ferry passengers study performed within sea way project covered twenty ports six countries adriatic ionian region hinterland connections assessment primary objective database enable comprehensive view data making easier focus analysis database functionalities systematization timelines collection data entry one place using user friendly interface developing big databases database sea way project need making model provide integrity interconnectedness data relational databases dominated software industry long erd entity relationship diagram used visually represents relationship database entities also important decide dbms database management system use creating database paper presented solution sea way project database useful assessment tool ports stakeholders adriatic ionian macro region
deployment ami technologies large facilities sets new challenges due difficulty perform experiments physical large settings high number users propose framework domain using simulations combine social simulation techniques specialized assessing large population behaviors along experience ami systems simulations specialized considering sensor actuator networks embedded physical environment framework allow configuration simulation features options according user device models defined domain experts well interaction proposed simulator context generated external sources simulators ami infrastructures paper also proposes first steps towards implementation architecture contributions known simulators
noise pollution urban environment issue serious concern major cities india various factors contribute increase noise levels urban areas intensity traffic one factors contributes drastic increase environmental noise management noise pollution considered decision making process paper attempt made study existing noise level due traffic velachery declared sensitive area ministry environment forestry moef noise level data collected using digital sound meter custic simulation software version used finding propagation noise spatial patterns measurement also calculated sub urban area velachery chennai tamilnadu india means transmitting data vehicles moving area wireless medium simulated using nctuns network simulator enable drivers understand environmental conditions hardware also designed used transmit receive noise data using zigbee module noise transmitting station placed junction transmit noise data receivers fitted inside vehicles
background influence life events suicidal behavior remains inconclusive reasons living rfl may protective objectives analyze association positive negative life events suicidal ideation interaction life events rfl method patients history suicide attempts underwent comprehensive clinical evaluation including beck suicidal ideation scale rfl reasons living inventory rfli life events family school student professional social health religion related life events last twelve months results negative life events associated health related events family related positive life events rfl negatively associated respectively significant interaction number positive life events rfli total score current detected family related positive life events rfl additive effect positive life events moderate association health related negative life events limitations retrospective study presence axis disorders investigated results generalized due sample choice suicide attempters conclusions patients history suicide attempts could less sensitive negative life events except related health clinicians pay attention somatic problems patients risk suicide family support positive psychology therapies strengthen rfl developed prevent suicide elsevier ltd rights reserved
microgeneration technologies positioned address future building energy efficiency requirements facilitate integration renewables buildings ensure sustainable energy secure future paper explores development robust multi input multi output mimo controller applicable control hybrid renewable microgeneration systems objective minimising electrical grid utilisation building fulfilling thermal demands controller employs inverse dynamics building servicing systems energy storage robust control methodology inverse dynamics provides control system knowledge complex cause effect relationships system controlled inputs external disturbances outer loop control ensures robust stable control presence modelling deficiencies uncertainty unknown disturbances variable structure control compensates physical limitations systems whereby control strategy employed switches depending current utilisation availability energy supplies preliminary results presented system consisting micro chp unit solar battery storage indicate control strategy effective minimising interaction local electrical network maximising utilisation available renewable energy published elsevier ltd
work outlines equation based formulation digital control program transducer interacting continuous physical process approach using coq theorem prover verifying performance combined hybrid system considering thermal dynamics linear dissipation simplicity focus generalizable physically consistent description interaction real valued temperature digital program acting thermostat interest work discovery formal proof bounds temperature degree variation performance characteristics approach explicitly addresses need mathematically represent decision problem inherent analog digital converter rare values take arbitrarily long time produce digital answer called buridan principle constraint ineluctably manifests verification thermostat performance furthermore temporal causality constraints thermal physics must made explicit obtain consistent model analysis discuss significance findings toward verification digital control complex physical variables fields
paper aims investigate stress management skills christian orthodox monks nuns measured antonovsky scale sense coherence soc case control study designed test hypotheses whether monks nuns higher soc secular people study population consisted individuals monks nuns study group secular men women control group soc score higher monks nuns compared secular population men compared women persons older age compared younger individuals
multivariate spatial extremes inference max stable processes observed large collection points challenging problem current approaches typically rely less expensive composite likelihoods constructed small subsets data work explore limits modern state art computational facilities perform full likelihood inference efficiently evaluate high order composite likelihoods extensive simulations assess loss information composite likelihood estimators respect full likelihood approach widely used multivariate spatial extreme models discuss choose composite likelihood truncation improve efficiency also provide recommendations practitioners article supplementary material online
hydrogen isotherms measured solid solution low content fcc alloys content ranges available approximate mpa delta ash determined isotherms dilute phase region function content alloys thermodynamic parameters determined hydride formation decomposition reactions temperature dependence plateau pressures hysteresis determined alloys alloy form hydride phase alloys internally oxidized form composites solubilities determined isotherms indicate trapping tio interfaces enthalpies trapping determined reaction calorimetry internally oxidized alloy relative partial enthalpies absorption quite negative compared solution dilute phase pure results probe properties metal oxide interfaces important number technological applications elsevier rights reserved
transition parenthood rite passage adults however given dynamic state gender roles society parameters surrounding ease difficulty transition evolving purpose paper introduce work included special issue gender transition parenthood academic literature filled articles women cope transition parenthood variety perspectives including feminist perspective however much literature dated account today gender roles society particularly fathers may influence transition parenthood argue rapidly changing gender roles society crucial consider three perspectives parenting ten works included special issue represent three perspectives seek understand transition parenthood intersection today gender roles based works authors encourage researchers interested transition parenthood incorporate male female perspectives well interplay genders making transition smooth difficult following brief overview existing literature introduce articles special issue papers special issue based samples
objectives exposure violence associated chronic physical conditions adults although violence exposure common among youths unknown whether violence associated chronic physical conditions childhood adolescence examined associations violence exposure chronic physical conditions population representative sample adolescents determined whether associations explained occurring mental disorders methods data drawn national comorbidity survey replication adolescent supplement ncs national cross sectional survey adolescents ages lifetime exposure violence diagnostic statistical manual mental disorders fourth edition mood anxiety substance disorders self reported arthritis frequent headaches back neck problems chronic pain asthma allergies assessed results one adolescents reported exposure violence violence exposure associated elevated odds back neck pain headaches chronic pain allergies asthma odds ratio confidence interval adjustment sociodemographics socioeconomic status lifetime mental disorders regarding new sets violence exposure associated greater hazard subsequent first onset back neck pain hazard ratio headaches hazard ratio associations explained earlyonset mental disorders conclusions childhood violence exposure associated chronic physical conditions emerge early life course although associations stronger prevalent incident conditions violence exposure predicts incident pain conditions associations explained mental disorders begin violence exposure interventions policies aimed preventing violence detecting treating early onset mental disorders potential reduce morbidity mortality health disparities beginning early development
paper discusses high bandwidth trans impedance amplifier combined data acquisition system high sampling rate building nanopore system detection platform measured currents vary nanoamperes output voltage processed computer amplifier must constructed multi stages key point designing amplifier low noise technique especially head stage application nanopore system single molecule detection amplifier achieve bandwidth mhz detection sensitivity chose main operational amplifier chips trans impedance amplifier also designed three level enlarged circuit using trans impedance amplification principle preamplifier circuit also selected high precision metal foil resistors high stability feedback resistor entire amplifier noise low possible second third enlarged circuit continuous voltage amplification improving input impedance lowering output impedance object achieved circuit designing making trans impedance amplifier improve loading capacity characteristics trans impedance amplifier include low cost excellent performance provide broader prospects weak signal detection biomedical research
aims deletion syndrome neurogenetic condition associated increased risk developing schizophrenia previous studies shown negative symptoms represent specific clinical characteristic psychosis strongly associated outcome however psychological mechanisms associated symptoms population poorly understood accordance recent conceptualizations field schizophrenia present study aims investigating whether negative symptoms associated presence negative performance beliefs cognitive deficits methods thirty five participants typically developing individuals aged years included study self reported schizotypal symptoms cognitive perceptual paranoid negative disorganization symptoms dysfunctional beliefs negative performance beliefs need approval assessed measures processing speed verbal memory working memory executive functioning face recognition also extracted broad cognitive evaluation protocol results adolescents reported significantly higher score negative dimension schizotypal personality questionnaire controls even controlling influence anxiety depression intellectual functioning negative paranoid symptoms associated severity negative performance beliefs lower face recognition abilities mediation analyses revealed negative performance beliefs significantly mediated association face recognition negative paranoid symptoms conclusions findings suggest negative performance beliefs basic social cognitive mechanisms associated negative paranoid symptoms individuals implications intervention discussed article
paper two main works introduced optical analog signal processing soi based microring resonators high order differentia tors cascaded microring resonators including first second third order differentiators demonstrated optical differential equation solver microring resonators first proposed demonstrated
purpose white paper call research intersection dress type diabetes adolescent development management requires frequent blood glucose monitoring individual dependent regular delivery insulin injections insulin pump much literature focuses fostering healthy habits role dress identity rarely addressed example adolescent teen employed demonstrate equipment blood glucose control fulfills definition dress review literature reveals body knowledge dress identity adolescent development identity interdisciplinary research intersection three factors needed point life teens want look unique different friends managing gear maintains health communicates diabetic identity must better understood support patient
hybrid systems class dynamical systems whose behaviors based interaction discrete continuous dynamical behaviors since general method analysis hybrid systems available researchers focused specific types hybrid systems piecewise affine pwa systems one subsets hybrid systems identification pwa systems includes estimation parameters affine subsystems coefficients hyperplanes defining partition state input domain paper proposed pwa identification approach based modified clustering technique using fuzzy pca guided robust means clustering algorithm along neighborhood outlier detection two main drawbacks well known clustering algorithms poor initialization presence outliers eliminated furthermore modified clustering technique enables determine number subsystems without prior knowledge system addition applying structure state input domain considering time sequence input output pairs provides efficient clustering algorithm novelty work finally proposed algorithm evaluated parameter identification igv servo actuator simulation together experiment analysis proved effectiveness proposed method
low fodmap diet new dietary therapy management irritable bowel syndrome gaining popularity around world developing low fodmap diet required extensive food composition data also establishment cutoff values classify foods low fodmap cutoff values relate particular fodmap present food including oligosaccharides fructans galactooligosaccharides sugar polyols mannitol sorbitol lactose fructose excess glucose cutoff values derived considering fodmap levels typical serving sizes foods commonly trigger symptoms individuals irritable bowel syndrome well foods generally well tolerated reliability fodmap cutoff values tested number dietary studies development techniques quantify fodmap content foods greatly advanced understanding food composition fodmap composition affected food processing techniques ingredient selection usa use high fructose corn syrups may contribute higher fodmap levels detected via excess fructose processed foods food processing techniques ingredients vary countries comprehensive food composition data needed diet easily implemented internationally
evade well known impossibility unconditionally secure quantum two party computations previous quantum private comparison protocols adopt third party study far two parties propose feasible efficient protocol intriguingly although average amount information leaked made arbitrarily small find average exceed bits length bit string compared
chinese fusion engineering testing reactor cfetr first fusion energy generation device china based structure iter like superconducting tokamak fusion power cfetr designed first phase duty cycle designed order optimize steady state electrical network ssen type transformer model used analyze influence short circuit impedance voltage regulation factor reactive power loss short circuit current iter like lower short circuit impedance implemented main step transformers accordance comparisons annual operating cost year comprehensive loss efficiency silicon steel transformers amorphous transformers amorphous core adopted distribution step transformers realize high efficiency energy saving
primary objective considerable evidence suggesting facial affect recognition cognitive functions impaired many people moderate severe traumatic brain injury tbi however little known relationship two domains tbi population research design study investigated relationship facial affect recognition cognitive functioning adults moderate severe tbi methods procedures participants administered three facial affect recognition tests computerized cognitive test battery assessed seven cognitive domains main outcomes results deficits facial affect recognition significantly correlated impairments non verbal memory working memory speed processing verbal memory verbal delayed memory significant relationship found executive dysfunction facial affect recognition impairments non verbal memory working memory speed processing significantly predicted overall facial affect recognition performance conclusions concluded impairment several cognitive processes may contribute facial affect recognition deficits tbi particular non verbal memory working memory speed processing furthermore executive functioning may critical factor facial affect recognition would likely important deciding facial affect perceived
paper presents experimental results obtained memristor based wien bridge oscillator implemented using new memristor emulator memristor emulator implemented using shelf components experimental results show nonlinear chaotic well linear oscillations obtained circuit careful adjustment value single resistor proposed circuit easily presented undergraduate laboratory course demonstrate use memristors generating chaotic oscillators
role testosterone cardiovascular health men controversial data suggest hypogonadism associated mortality morbidity however recent evidence shows hypogonadal subjects treated replacement therapy higher incidence new events aim study analyse whether gonadal status might predict new event incidence according patient previous history events cohort subjects complaining sexual dysfunction consecutive series patients followed mean time years new occurrence events detecting events hypogonadism total nmol associated increased incidence new events entire cohort however considering patients previous history events hypogonadism associated reduced risk new events even adjusting confounders hazard ratios whereas relationship observed subjects free previous events similar results observed reduced testis volume considered predictor new events subjects previous events patients history previous events without previous events low low associated lower incidence new events compared subjects one none conditions even adjusting confounders trend notably risk estimated risk engines based traditional risk factors different hypogonadal eugonadal subjects conclusion hypogonadism could interpreted protective mechanism unhealthy conditions previous events avoid fatherhood spare energy
goal project investigate whether consumer ethnocentrism purely conscious mechanism based ideology suggested shimp sharma rather automatic unconscious process aim project introduction implicit consumer ethnocentrism ice concept measured implicit association test iat goal four studies conducted investigate following issues whether ice automatic mechanism underlying preference local products foreign could observed next ideologically based classic consumer ethnocentrism happens consumer automatic preference local products ice confronted objective evidence superiority foreign products inferiority local products assumed ice could reduced foreign products associated higher level competence local products could explain preference foreign products local often observed less developed countries study ice different product categories existing brands tested study ice measured context non existent brands studies showed strong group brand preference confirmed existence new phenomena ice results studies indicated strong automatic group brand favoritism effect measured iat participants preferred local brands foreign however inclusion well known foreign brands associated high competence reduced iat effect group preference
stress one key factor impacts quality daily life fromthe productivity efficiency production processes ability civilian military individuals making rational decisions also stress propagate one individual working close proximity toward common goal military operation workforce real time assessment stress individuals alone however sufficient understanding source direction propagates group people equally important continuous near real time situ personal stress monitoring system quantify level stress individuals direction propagation team envisioned however stress monitoring individual via mobile device may always possible extended periods time due limited battery capacity devices overcome challenge novel distributed mobile computing framework proposed organize resources vicinity form mobile device cloud enables offloading computation tasks stress detection algorithm resource constrained devices low residual battery limited cpu cycles resource rich devices framework also supports computing parallelization workflows defining data tasks divided assigned among entities framework designed direction propagation magnitude influence stress group individuals studied applying real time situ analysis granger causality tangible benefits terms energy expenditure execution time proposed framework comparison centralized framework presented via thorough simulations real experiments
oxycodone deterx collegium pharmaceutical inc canton massachusetts extended release microsphere capsule abuse deterrent formulation designed retain extended release properties tampering chewing crushing randomized double blind placebocontrolled triple dummy study evaluated oral abuse potential intact chewed oxycodone deterx capsules compared crushed immediate release oxycodone subjects history recreational opioid use nondependent nontolerant opioids enrolled treatments included intact oxycodone deterx high fat high calorie meal fasted chewed oxycodone deterx high fat high calorie meal fasted crushed immediate release oxycodone fasted placebo high fat high calorie meal plasma samples collected determine pharmacokineticparameters primary endpoint drug liking moment endpoints included drug effects questionnaire scores addiction research center inventory morphine benzedrine group score pupillometry measurements safety thirty eight subjects completed study chewed intact oxycodone deterx bioequivalent unlike crushed immediate release oxycodone yielded higher peak oxycodone plasma concentrations compared methods oxycodone deterx administration mean maximum peak effect emax drug liking significantly lower chewed intact oxycodone deterx crushed immediate release oxycodone time emax significantly longer chewed intact oxycodone deterx crushed immediate release oxycodone scores feeling high addiction research center inventory morphine benzedrine group scores demonstrated lower abuse potential chewed intact oxycodone deterx compared crushed immediate release oxycodone study treatments well tolerated subjects experienced serious adverse events results demonstrate lower oral abuse potential chewed intact oxycodone deterx crushed immediate release oxycodone
various compositions mixture silver nickel oxide nio powders studied use cathode contact material solid oxide fuel cell stacks addition nio intended mitigate evaporation maintain low resistivity contact material stack operation found mixture form pellets consisting mol mol nio yield acceptable area specific resistance asr omega degrees reduced weight loss however steel nio paste steel assemblies prepared mol mixed powders paste containing mixed powder high asr values similar omega thermal exposure degrees observed low resistivity pellet mol attributed formation effective conducting pathways complete sintering densely packed particles pressing process producing pellets steel nio paste steel assemblies particles scattered within nio layer readily get sintered found resistance nio mixture critically depends mass concentration powder ceramic society japan rights reserved
developmental exposure turtles reptiles endocrine disrupting chemicals edcs including bisphenol bpa ethinyl estradiol estrogen present birth control pills induce partial full gonadal sex reversal males prior studies considered whether ovo exposure edcs disrupts normal brain sexual differentiation yet rodent model studies indicate early exposure chemicals disturbs sexually selected behavioral traits including spatial navigational learning memory thus sought determine whether developmental exposure painted turtles chrysemys picta bpa results sex dependent behavioral changes developmental stage turtles incubated degrees male inducing temperature treated bpa high bpa low vehicle vehicle control groups five months hatching turtles tested spatial navigational test included four food containers one baited food turtle randomly assigned one container change trial period individual tested consecutive days results show developmental exposure bpa high improved spatial navigational learning memory evidenced increased number times spent correct target zone greater likelihood solving maze compared control turtles study first show addition overriding temperature sex determination tsd male gonad edcs may induce sex dependent behavioral changes turtles elsevier inc rights reserved
objective randomized controlled trial examined efficacy triple online brief low intensity online positive parenting program parents children early onset disruptive behavior problems method two hundred parents year old children displaying early onset disruptive behavior difficulties randomly assigned either intervention condition waitlist control group results week post assessment parents intervention group displayed significantly less use ineffective parenting strategies significantly confidence dealing range behavior concerns effects maintained month follow assessment delayed effect found child behavior problems parents intervention group reporting significantly fewer less frequent child behavior problems follow post assessment effect sizes small medium range significant improvements observed negative parent child behavior change seen parents adjustment anger conflict parenting consumer satisfaction ratings program high conclusions brief low intensity parenting program delivered via internet bring significant improvements parenting child behavior elsevier ltd rights reserved
prefix table string one fundamental data structures algorithms strings determines longest factor position string matches prefix string computed time linear respect size string hence used efficiently locating patterns regularity searching strings weighted string string set letters may occur position respective occurrence probabilities weighted strings also known position weight matrices uncertain strings naturally arise many biological contexts example provide method realise approximation among occurrences dna segment article given weighted string length constant cumulative weight threshold defined minimal probability occurrence factors present time algorithm computing prefix table furthermore outline number applications result solving various problems non standard strings present preliminary experimental results elsevier rights reserved
essay examines consequences called big data technologies biomedicine analyzing algorithms data structures used biologists provide insight biologists perceive understand objects study examine widely used algorithms genomics used sequence comparison sequence mapping algorithms derived powerful tools text searching indexing developed since play important role online search biology sequence comparison algorithms used assemble genomes process next generation sequence data recently precision medicine argue predominance specific set text matching pattern finding tools influenced problem choice genomics allowed genomics continue think genomes textual objects increasingly lock genomics big data driven text searching methods many big data methods designed finding patterns human written texts however genomes omic data human written unlikely meaningful way
although emerging evidence suggested association valmet polymorphisms brain derived neurotrophic factor bdnf gene panic disorder conclusion inclusive given mixed results meta analysis reviewed analyzed recent studies addressing potential association valmet polymorphisms panic disorder susceptibility related case control studies retrieved database searching selected according established inclusion criteria six articles identified explored association bdnf valmet polymorphism panic disorder statistical analyses revealed association allele contrast dominant model however recessive model showed significant association bdnf valmet polymorphism panic disorder odds ratio confidence interval despite limitations meta analysis suggests valmet polymorphism bdnf gene susceptibility factor panic disorder
currently approved drugs schizophrenia work mainly dopaminergic antagonism efficacious psychotic symptoms efficacy limited negative symptoms cognitive deficits underlie substantive disability illness recent insights biological basis schizophrenia especially relation non dopaminergic mechanisms raised efforts find novel effective drug targets though relatively little success thus far potential impediments novel drug discovery include continued use symptom based disease definitions leads etiological pathophysiological heterogeneity lack valid preclinical models drug testing design limitations clinical trials roadblocks addressed characterizing trans diagnostic translational pathophysiological dimensions potential treatment targets efficiency accountability transparency approaches clinical trials process iii leveraging recent advances genetics vitro phenotypes accomplishing goals urgent given significant unmet needs pharmacological treatment schizophrenia happens imperative clinicians employ optimal dosing measurement based care best practices utilizing existing treatments optimize outcomes patients today elsevier ltd rights reserved
study objective assess initiation sexual activity contraception methods used among greek adolescents determine association adolescents emotional behavioral status sexual activity design descriptive cross sectional survey conducted setting participants population age consisted random sample stratified according locality population density public junior high high schools located urban district athens greece interventions anonymous self reported questionnaires used assess sexual activity choices contraception methods youth self report questionnaire used evaluate psychosocial competencies difficulties greek adolescents measures analyses included frequencies chi square tests multivariate logistic regression analysis main outcome factors may influence sexual engagement greek adolescents assessed results adolescents completed questionnaire reported experienced sexual intercourse male female ratio mean age sexual debut years condoms preferred contraceptive method followed withdrawal emergency contraception used participants adolescents separated divorced deceased parent non greek nationality higher possibility sexually active adolescents reported sexual intercourse significantly higher score thought problems beta attention difficulties beta delinquent behavior problems beta aggressive behavior beta externalizing problems beta conclusions engagement sexual activities significantly associated psychosocial difficulties among adolescents living greece
researchers interest recently moved toward identification recurrent psychopathological profiles characterized concurrent elevations different behavioural emotional traits new strategy turned useful terms diagnosis outcome prediction used person centred statistical approach examine whether different groups could identified referred sample general population sample children adolescents investigated relation dsm diagnoses latent class analysis lca performed child behaviour checklist cbcl syndrome scales referred sample general population sample total sample models estimating class class solutions compared agreement classification subjects evaluated chi square analyses logistic regression multinomial logistic regression analysis used investigate relations classes diagnoses two samples total sample best fitting models class solutions identified classes internalizing problems severe dysregulated attention hyperactivity low problems subsequent analyses indicated significant relationship diagnoses classes well main association severe dysregulated class comorbidity data suggested presence four different psychopathological profiles related different outcomes terms psychopathological diagnoses particular results underline presence profile characterized severe emotional behavioural dysregulation mostly associated presence multiple diagnosis
hereditary angioedema normal esterase inhibitor hae ncinh perioperative rare condition could potential disastrous ramifications anesthesiologist perioperative period however limited evidence guidelines optimal way manage patients present case patient hae ncinh successfully managed perioperative period plasma derived esterase inhibitor pdcinh year old woman diagnosis hae ncinh presented preoperative consultation preparation upcoming total thyroidectomy year history ongoing lip facial edema sometimes necessitating emergency department visitation close consultation immunologist transfusion medicine specialists anesthesia care providers allowed preoperative plan provide patient adequate prophylaxis pdcinh tranexamic acid given preoperatively patient underwent surgery complications multi disciplinary team clinical immunologists transfusion medicine specialists anesthesiologists facilitated successful perioperative management patient hae ncinh pdcinh may suitable prophylactic perioperative therapy rare patient population elsevier inc rights reserved
cloud gaming become new trend gamers access high end video games rendering games remote cloud streaming video scenes users games played anywhere anytime device smartphones tablets personal computers paper address problem achieving cost effective adaptive cloud gaming geo distributed data centers perspective cloud gaming service providers cgsps unlike previous work consider cloud gaming system supported adaptive streaming technology purpose minimize overall service cost cgsps adaptively adjusting selection data centers virtual machine allocation video bitrate configuration user meanwhile also need ensure good enough quality experience qoe gamers objective formulate problem constrained stochastic optimization problem apply lyapunov optimization theory drive corresponding online strategy provable upper bounds due diverse qoe requirements video games also take difference among game genres account algorithm design finally conduct extensive trace driven simulations evaluate effectiveness algorithm results show proposed algorithm achieve significant gain alternative approaches
characterization nonlinear dynamical systems attractors terms invariant measures basins attractions structure vector fields usually outlines task strongly related underlying computational cost work practical aspects related use parallel computing specially use graphics processing units cpus compute unified device architecture cuda reviewed discussed context nonlinear dynamical systems characterization work characterization performed obtaining local global lyapunov exponents classical forced duffing oscillator local divergence measure employed computation lagrangian coherent structures lcss revealing general organization flow according obtained separatrices global lyapunov exponents used characterize attractors obtained one bifurcation parameters simulation sets also illustrate required computation time speedup gains provided different parallel computing strategies justifying employment relevance gpus cuda extensive numerical approach finally simply providing overview supported representative set simulations work also aims unified introduction use mentioned parallel computing tools context nonlinear dynamical systems providing codes examples executed matlab using cuda environment something usually fragmented different scientific communities restricted specialists parallel computing strategies elsevier rights reserved
study investigates whether eight ancient principles javanese statesmanship asta brata employed basis analysing managerial leadership excellence javanese organizations factor analysis regression modelling structural modelling used explain constitutes leadership excellence javanese organizations findings based perceptions javanese managers suggest favour paternalistic leadership style nurturing authoritative study highlights importance understanding indonesia bapak ism reverence leader father figure familial orientation interdependency management employees
youth autism spectrum disorder asd experience significant difficulties assuming adult responsibilities achieving independence little known desire ability manage finances study explored financial circumstances money management skills desires financial independence among youth asd youth took part min semi structured interviews independence strategies theme analysis identified three critical themes finances emerging adulthood youth asd youth defined independence able manage finances worried lack money management skills cited poor financial skills barrier independence results suggest youth asd understand importance financial capability strive financial independence lack skills support needed achieve financial goals study provides preliminary information clinicians educators researchers develop financial capability modules youth asd
revisit properties two component fermi gas short range interactions three dimensions limit wave scattering length diverges unitary fermi gas possesses universal thermodynamic dynamical observables independent interaction length scale focusing trapped systems fermions ninfinity
article presents innovative pressure feedback method address undesired payload oscillations hydraulic load handling machines negative impact machine productivity safety tracking control techniques machines often applicable due difficulty cost associated installation feedback sensors payload work means pressure sensors installed hydraulic system payload oscillation frequency first detected analyzing frequency content measured pressure counteracted sinusoidal based excitation command machine actuator work particularly addresses challenges related use actuator detecting quantifying oscillation frequency amplitude reducing payload oscillations fact interference feedback pressure signal due control action present experimental results truck mounted hydraulic crane show proposed technique permits reduce payload oscillation order comparable less practical tracking control techniques
rapid development energy electricity transportation industries created market steel pipes however buried steel pipelines near high voltage transmission lines electrified railways often experience alternating current corrosion damaged coating pipelines phenomenon mostly due resistance capacitance inductance coupling especially long distance pipelines parallel operation corrosion cause pipeline corrosion perforation stress corrosion cracking scc cases vital threat pipeline safety work influence corrosion behavior pipeline steel investigated near neutral solution data acquisition technique electrochemical test immersion tests surface analysis techniques results show increasing density corrosion morphology changed uniform corrosion localized corrosion many pits full interference steel occurred cathodic anodic polarization resulted iron dissolution hydrogen precipitation negative half wave would lead hydrogen evolution hydrogen induced anodic dissolution pits steel surface present sharp however disturbance positive half wave anodic dissolution occurred pitting appeared spill shape smoothly various waveform interference corrosion products steel surface different full wave positive half wave interference corrosion products loose alpha feooh occurred cracks however negative half wave interference corrosion products denser contained alpha feooh protective effect substrates
expression blastoid cutaneous infiltrates typically signifies lymphoproliferative disorder often requiring minimal immunohistochemical workup clinically consonant however myeloid hematologic malignancies often express retrospectively examined prevalence expression patients median age biopsies diagnosis leukemia cutis determine whether extensive immunohistochemical workup warranted large round cell cutaneous infiltrates patient refractory recurrent disease histologic presence large mononuclear cell infiltrate varied cytogenetics mononuclear cells within infiltrate ranged rare many biopsies biopsies cells interpreted lymphocytic based morphology strong cytoplasmic golgi staining negative staining one case showing staining lymphocytes identified posttransplant lymphoproliferative disorder second case favored represent subset positive acute myeloid leukemia three cases membranous cytoplasmic staining interpreted myeloid leukemia conclusion positivity myeloid leukemia skin rare often exhibit strong membranous golgi staining seen reactive lymphocytes acute myeloid leukemia myeloid may occasionally show rarely cytoplasmic membranous nonspecific blush nuclear labeling strong diffuse staining prompt consideration reactive lymphoid lymphoproliferative process clinical likelihood low may obviate need immunohistochemistry
background aims regulation water channel aquaporins aqps provides another mechanism abscisic acid aba may influence water flow plants best knowledge studies addressed changes aba levels abundance aqps root cell hydraulic conductivity cell tissues thus followed mechanisms aba affects root hydraulics aba deficient barley mutant parental line steptoe compared abundance aqps aba cells determine spatial correlations aqp abundance local aba concentrations different root tissues addition abundance aqps aba cortex cells related cell methods root hydraulic conductivity root measured means root exudation analyses cell using cell pressure probe abundance aba aqps root tissues assessed immunohistochemical analyses isoform specific antibodies raised hvpip hvpip hvpip used key results immunolocalization revealed lower aba levels root tissues compared steptoe root hydraulic conductivity root lower yet abundance hvpips root tissues similar two genotypes root hair formation occurred closer tip length root hair zone shorter steptoe application external aba root medium steptoe increased immunostaining root cells aba hvpip hvpip especially root epidermal cells cortical cell layer located beneath parallel increase root cell treatment roots fenton reagent inhibits aqp activity prevented aba induced increase root hydraulic conductivity conclusion shortly aba application roots aba deficient barley increased tissue aba concentrations aqp abundance especially plasma membrane localized isoforms hvpip hvpip spatially correlated root epidermal cells cortical cell layer located beneath conjunction increased cell cortical cells contrast long term aba deficiency throughout seedling development affects root hydraulics mechanisms particular developmental timing formation root hairs closer root tip length root hair zone
sustainability become priority dubai throughout united arab emirates dedication global sustainability may seen innovative efforts masdar commitment leadership sustainable principles numerous alternatives exist green building design advance support commitment includes usgbc leed sustainable sites sites approaches breeam dubai green building regulations abu dhabi estidama pearl system specific philosophies considerations may vary approach focus design order promote ensure long term energy sustainability green buildings also constructed using green construction techniques subsequently efforts underway sponsorship emirates foundation explore approaches evaluating sustainability construction site operations available sustainable design options examined evaluate construction specific parameters adequacy collective information examined recommendations made regarding construction implementation authors published elsevier ltd
objective evaluate feasibility conducting randomized controlled trial comparing group based outpatient physiotherapy usual care patients following total knee replacement design feasibility study randomized controlled trial setting one secondary care hospital orthopaedic centre bristol participants total participants undergoing primary total knee replacement interventions intervention group offered six group based exercise sessions surgery usual care group received standard postoperative care participants blinded group allocation outcome measures feasibility assessed recruitment reasons non participation attendance completion rates study questionnaires included lower extremity functional scale knee injury osteoarthritis outcome score results recruitment rate five patients withdrew longer eligible participate intervention attendance high group participants reported satisfied exercises return study questionnaires six months lower usual care intervention group mean standard deviation lower extremity functional scale scores six months usual care intervention groups conclusion recruitment retention participants feasibility study good group based physiotherapy acceptable participants questionnaire return rates lower usual care group might enhanced telephone follow lower extremity functional scale high responsiveness completion rates using outcome measure participants would required full scale randomized controlled trial
objective individuals neurologic disorders self awareness cognitive impairment associated improved treatment course clinical outcome however methods assessment levels self awareness limited require collateral information may readily available although distortions self awareness often associated low cognitive ability frequently mixed pattern cognitive strengths deficits individuals neurologic disorders complicates assessment present study explores relationships actual test performance self ratings utilizing brief probe administered testing common metric approach solicits self appraisal ratings percentile equivalents capitalizes available normative data specific standardized neuropsychological tests allow direct comparisons method convenience sample adults recruited community sources participated study including healthy adults neuropsychologically risk volunteers hiv positive endorsing heavy current alcohol consumption immediately following completion standardized neuropsychological tests participants estimated percentile ranking results across study groups participant estimates percentile rank modestly correlated actual performance ranking highest correlations obtained tests learning memory conceptual reasoning executive function smaller correlations simple tests motor psychomotor speed conclusions study reveals normal biases affecting self appraisal standardized testing suggests common metric approach assessing self appraisal may play role establishing clinical thresholds identifying quantifying reductions insight persons neuropsychological deficits
recent approaches network functions virtualization nfv shown commodity network stacks drivers struggle keep increasing hardware speed despite popular cloud networking services still rely commodity operating systems oss device drivers taking account hardware underlying commodity servers built nfv profiler tracks movement packets across system memory hierarchy collecting key hardware level performance counters leveraging profiler data service chain coordinator scc run time accelerates user space nfv service chains based commodity drivers scc combines multiplexing system calls scheduling strategies taking time priority processing load account granting longer time quanta chained network functions nfs combined multiplexing scc reduces unnecessary scheduling overheads resulting three fold latency reduction due cache main memory utilization improvements importantly scc reduces latency variance nfv service chains compared standard fastclick chains making average case nfv chain perform well best case improvements possible profiler accuracy author published elsevier inc open access article license http creativecommons org licenses
oyster shells research function cement fine aggregate substitution well provide aesthetic value concrete materials types shells observed research green mussels perna viridis linn blood clams anadara granosa linn scallops placuna placenta linn paper compares performances concrete materials made three oyster shells density compressive strength acoustical aspects consisting sound transmission loss stl absorption coefficient green material made anadara granosa linn shell greatest compressive strength value acoustical tests show three materials range stl greatest absorption coefficient material made perna viridis shell value
previous research memory metamemory processes obsessive compulsive disorder ocd almost exclusively addressed veridical memory present study investigated veridical false memory recall recognition nonpresented information well confidence ocd compared checker ocd non checker ocd healthy control participants using deese roediger mcdermott drm false memory paradigm participants given word lists consisted semantically related words strong associates non presented critical target word given free recall recognition task although ocd groups showed comparable correct recall recognition performance group ocd groups less prone false memories reported lower confidence false memories group accuracy global recognition estimates similar across three groups pattern results may partly due ocd groups reliance item based rather relational processing encoding elsevier inc rights reserved
design paper proposes improvements existing electrical network aircraft system also suggests improvement starter circuitry introducing super capacitors reduce number batteries board ensure improved safety reliability proposes higher frequency power distribution owing several benefits several advantages high frequency power distribution conventional distribution low frequency power distribution paper explores idea employing switched capacitor switched inductor converters design multi level inverters high frequency power supplies power distribution
interstitial lung disease ild group chronic respiratory diseases characterized dyspnoea exertion decline health related quality life hrql people ild experience significant exercise limitation contributors include ventilatory limitation impaired gas exchange decreased cardiac function skeletal muscle dysfunction pulmonary rehabilitation well established patients chronic obstructive pulmonary disease copd means overcome exercise limitation improve activity related dyspnoea increasing evidence similar effects people ild review discusses evidence ild outlines essential components population highlights special considerations exercise training people ild possible future directions research people ild explored
study examines family characteristics put adolescent girls increased risk abuse mainly physical sexual emotional abuse neglect stratified random sampling done among classes government girls schools semi urban area delhi total adolescent girls participated majority mid adolescence approximately study subjects faced least one form maltreatment physical abuse faced sexual abuse emotional abuse neglect study subjects frequent perpetrator physical emotional abuse mother sexual abuse friends relatives neighbours low education father increased odds physical emotional abuse odds physical abuse neglect lower mothers housewives excessive arguments parents history maltreatment parents increased odds child maltreatment study subjects
study design cohort workers representative sectors industry compensated low back injury previous years followed months objectives determine prognostic value physician initial diagnosis back problems summary background data absence standardized classification diagnoses back pain study aimed provide element validity classification previously proposed consists specific nonspecific back pain methods medical charts reviewed quebec worker compensation board extract diagnosis made treating physicians within days first day absence work diagnoses categorized specific lesions vertebrae discs nonspecific pain sprains strains history compensated work absence low back pain following months obtained results specific diagnosis found workers accounting patients accumulated months absence years increasing age daily amount compensation also associated increased risk chronicity conclusions physician initial diagnosis highly associated risk chronicity explanation result complex involving nature underlying lesion well impact diagnosis label worker physician patient relationship
development computer graphics technology machine vision virtual reality technology recent years reconstruction method sequence images outdoor scenes become key research direction computer vision graphics acquisition process image due measurement equipment environment single shot sequence photos may able extract enough surface information lead unable complete reconstruction objects solve problem fusion method point clouds multi group images adopted thesis firstly color histogram matching used complete supplement image sequence next point cloud supplement image sequence solely calculated transform parameters overlap area different point clouds computed using improved iterative closest point algorithm finally registration fusion among point cloud data different photos conducted experiments show method effectively supplement point cloud data reconstruction
autonomous car complex topic different technical fields like automotive engineering control engineering informatics artificial intelligence etc involved solving human driver replacement artificial agent driver problem even complicated usually nowadays driving car defines lifestyle means mentioned major transformation also cultural issue paper start mentioned cultural aspects related self driving car continue big picture system
paper analyze preconditioned gmres algorithm detail decompose components implement multiple gpu architecture operations vector updates dot products sparse matrix vector multiplication spmv implemented parallel addition specific communication mechanism spmv designed preconditioner established host cpu solved devices gpus validated series numerical experiments gpu based gmres solver effective favorable parallel performance achieved elsevier ltd rights reserved
investigation paper fifth order korteweg vries type fkdv type equation time dependent coefficients used describe many nonlinear phenomena fluid mechanics ocean dynamics plasma physics binary bell polynomials employed find hirota bilinear formalism extra auxiliary variable based soliton solutions also directly derived furthermore considering multi dimensional riemann theta function lucid straightforward generalization hirota riemann method presented explicitly construct multiperiodic wave solutions equation finally asymptotic properties periodic wave solutions strictly analyzed reveal relationships periodic wave solutions soliton solutions
latest studies practice guidelines treatment adolescent patients anorexia nervosa agree pointing key role played parents determining young patients therapeutic possibilities outcomes still family functioning usually studied using self reported instruments aim present study therefore investigate triadic interactions within families adolescents anorexia nervosa using semi standardized observational tool based recorded play session lausanne trilogue play ltp parents adolescent daughters consecutively referred adolescent neuropsychiatric services participated study underwent observational procedure lip families adolescent girls anorexia nervosa restricting type compared families patients internalizing disorders anxiety depression results showed different interactive patterns families adolescents anorexia nervosa greater difficulties respecting roles play maintaining joint attention sharing positive affect especially three together phase third phase majority families exhibited collusive alliances parental subsystem appeared frequently unable maintain structuring role providing help support guidance daughters girls turn often found hard show independent ideas develop personal projects parents experienced difficulty carving couple specific relational space ill daughter least temporarily excluded also asked continue interact letting daughter simply present third part position fourth phase study triadic interactions families adolescents anorexia nervosa may help shift attention exclusive mother daughter relation involvement father parental couple whole family functioning fact well established maintaining factor anorexia nervosa vice versa facilitating factor therapeutic process
pregnant women childbirth frequently experience memory deficits disrupted sleep present study assessed relationship false memory generation fragmented sleep pregnancy motherhood tested pregnant women female non pregnant childless controls pregnancy week gestation childbirth month false memories defined memories gist words semantically related studied word lists presented learning lists deese roediger mcdermott drm paradigm sleep monitored actigraphy home environment seven consecutive nights compared controls group pregnant women produced false memories displayed fragmented sleep pregnancy childbirth however false memory generation correlated measures sleep fragmentation results show pregnant women suffer sleep fragmentation higher susceptibility false memories leave open question whether phenomena related elsevier rights reserved
samples collected four seasons seven sites within city ofjeddah saudi arabia samples analysed range trace elements large loading wind blown dust majority elements predominantly associated coarse particles enrichment factors however show elements markedly enriched crustal abundance using mean data fractions seven sampling sites health risks estimated particulate matter mass elements measured study polycyclic aromatic hydrocarbons using data earlier study within jeddah cancer risks calculated mean airborne concentrations cancer slope factors carcinogenic metals pah cancer risks relatively modest compared lifetime risk mortality due exposure risks associated exposure considered small concentrations cadmium far exceed european union limit value world health organisation guideline cadmium shows high crustal enrichment factor present predominantly coarse particle fraction suggesting local soils surface dusts unusually enriched relative global average using national data mortality rates excess mortality due exposure calculated amounts deaths annually city jeddah elsevier rights reserved
continued effort reducing resource consumption greener technologies rainwater harvesting could useful diminishing dependence desalinated treated water associated energy requirements paper applies exergy analysis exergetic efficiency evaluate performance eight different scenarios urban rainwater harvesting systems mediterranean climate metropolitan area barcelona water scarce resource life cycle approach taken production use end life stages rainwater harvesting systems quantified terms energy material requirements order produce rainwater per year laundry purposes results show highest exergy input associated energy uses namely transport materials construct rainwater harvesting systems scenario highest exergetic efficiency considers household building rainwater storage tank installed roof exergy requirements could minimized material substitution minimizing weight distance traveled elsevier rights reserved
naphthalene sulfonates highly water soluble compounds indicating high mobility aquatic systems along high temperature stability important substances chemical industry review covers analytical methods instruments techniques used pre concentration analysis naphthalene sulfonates different matrices analytical steps including extraction real samples detection spectrophotometric chromatographic techniques well methods identification class compounds described detail methods normally employed extraction pre concentration compounds solid phase extraction including molecularly imprinted polymers anion exchange quantification performed using high performance liquid chromatography capillary electrophoresis gas chromatography mass spectrometry liquid chromatography mass spectrometry spectrophotometric techniques review addition chromatographic spectrophotometric methods electrochemical innovations appearing literature also explored
study aimed determine effect snapps summarize narrow analyze probe plan select method versus teacher centered education clinical skills midwifery students iran clinical trial midwifery students year education enrolled divided groups groups teacher centered education groups snapps method group spending days outpatient gynecology clinic questionnaire checklist used gather data independent test chi square test used analyze data ability gain trust patient verbal nonverbal communication skills history taking preparation patient gynecological examination diagnosis treatment common diseases significantly better snapps group compared teacher centered education group snapps education method significantly improve clinical skills midwifery students gynecology particular history taking differential diagnosis treatment common diseases
background combination antiretroviral therapy cart reduced mortality aids related illnesses chronic comorbidities become prevalent among hiv infected patients examined association hepatitis virus hcv infection chronic kidney disease ckd among patients initiating modern antiretroviral therapy methods data obtained canadian hiv observational cohort individuals initiating cart incident ckd defined two consecutive serum creatinine based estimated glomerular filtration egfr measurements months apart ckd incidence rates cart initiation compared hcv infected hiv mono infected patients hazard ratios hrs confidence intervals cis estimated using multivariable cox regression results included hiv infected patients egfr min cart initiation hcv infected one hundred fifty patients developed ckd person years follow pyfu ckd incidence rate higher among infected hiv mono infected patients per pyfu per pyfu adjusting demographics virologic parameters traditional ckd risk factors hcv infection associated significantly shorter time incident ckd additional factors associated incident ckd female sex increasing age years lower baseline egfr min increasing hiv viral load cumulative exposure tenofovir lopinavir conclusions hcv infection associated increased risk incident ckd among hiv infected patients initiating cart hcv hiv infected patients monitored kidney disease may benefit available hcv treatments
reinforcement learning methods computationally expensive cost prone higher cardinality state space representation becomes larger curse dimensionality plays important role work since gait generation using degrees freedom leg implies bigger state space discretization look tables become impractical thus appropriate function approximators needed kind tasks robotics chapter shows advantage using reinforcement learning specifically within batch framework neuroevolution augmenting topologies scheme used function approximator particular case topology weight evolving artificial neural network proved outperform fixed topology network certain tasks comparison function approximators within batch reinforcement learning approach tested simulated version hexapod robot designed already built undergraduate graduate students group
white box attack new attack context assumed cryptographic software implemented trusted platform implementation details controlled attackers far almost white box solutions broken study propose white box encryption scheme variant obfuscating existing ciphers completely new solution new scheme based unbalanced feistel network well asasasa means affine means substitution structure optional input block size suitable saving space compared solutions space requirement grows slowly linearly growth block size moreover scheme huge white box diversity white box ambiguity also particular construction bypass public white box cryptanalysis techniques including attacks aimed white box variants existing ciphers attacks specific asasasa structure precisely present definition white box security regard equivalent key prove scheme satisfies security requirement
experiments conducted quantify potential leakage holes two geomembranes thick linear low density polyethylene lldpe thick high density polyethylene hdpe placed silty sand underliner hydraulic conductivity kul kul pea gravel kul underliner foundation subgrade covered saturated fine tailings initial solids content discussed tailings hydraulic conductivity tests results show overlying tailings kul filled geomembrane hole larger effect flow hole underliners examined tested conditions leakage diameter holes essentially whereas leakage diameter hole three orders magnitude lower introduction nonwoven needle punched geotextile gtx layer geomembrane tailings increased flow approximately gap geomembrane hole attributable stone underliner filled tailings flowed hole evidence fines migration hole tailings underliner discussed
households usa state oklahoma serviced investor owned electric utilities smart meters may select charged based either traditional meter rate schedule smart meter schedule may install household grid tied wind turbine subject different rate schedule objective research determine economic consequences installing microgeneration grid tied wind turbine systems given alternative pricing structures households five unique locations different wind resources twenty years hourly wind speed data hourly electricity use data representative households obtained location annual household electricity cost among five locations ranged smart meter rates traditional meter rates estimated annual cost least costly household grid tied wind turbine system five times greater annual cost purchasing grid external consequences electricity generation distribution ignored given current proposed rate structures prices household wind turbine electricity generation systems economically competitive region elsevier ltd rights reserved
search active semiconductor photocatalysts utilize adequately solar energy remains open issue cdte nanoflakes nanowires range texture coefficients synthesized photocatalytic activities cdte nanocrystals degradation malachite green methyl orange acid red ciprofloxacin enhanced increasing texture coefficients reducing texture coefficient exposed polar facets found active facets charge separation model polar cdte cdte tit surfaces proposed internal electric field created polar cdte cdte tit surfaces spontaneous polarization internal electric field drives separation photoinduced electrons holes therefore cdte nanoflakes exposed polar facets synthesized using oleylamine morphology controlling agent show superior photocatalytic activity compared cdte nanowires nanocrystals irregular shapes commercial powders well cds branched nanostructures charge separation model provides clear opinion charge transfer semiconductor nanocrystals exposed active facets affords guidance design effective photocatalysts solar cells photoelectronic devices elsevier rights reserved
search prosocial personality long controversial current research explores general patterns underlying prosocial decisions linking personality emotion overt prosocial behavior using multimethod approach explored links big five dimensions personality prosocial responding across three studies found agreeableness dimension personality closely associated emotional reactions victims need help subsequent decisions help individuals results suggest prosocial processes including emotions cognitions behaviors may part general motivational process linked personality
persons homeless particularly mental health substance use disorders mhsuds often access receive continuous primary care services addition negative experiences primary care might contribute homeless persons avoidance early termination mhsud treatment patient centered medical home pcmh model aims address care fragmentation improve patient experiences homeless persons mhsuds experience care within pcmhs unknown study compared primary care experiences homeless nonhomeless veterans mhsuds receiving care veterans health administration medical home environment called patient aligned care teams sample included vha outpatients responded national pcmh survey health care experiences patients pcmh shep past year mshud diagnosis veterans evidence homelessness henceforth homeless identified vha administrative records pcmh shep survey respondents included veterans mhsuds homeless compared nonhomeless counterparts homeless veterans younger likely non hispanic black nonmarried less education likely live urban areas homeless veterans elevated rates mhsuds assessed indicating significant occurrence controlling differences homeless veterans reported negative fewer positive experiences communication negative provider ratings negative experiences comprehensiveness care coordination medication decision making self management support nonhomeless veterans homeless persons mhsuds may need specific services mitigate negative care experiences encourage continuation longitudinal primary care services
program project evaluation review technique pert remained modern method project scheduling decades since invention numerous authors tried modifications basic method attempt overcome intrinsic drawbacks paper authors research improvements fuzzy version pert initial motivation avoidance backward recursion problem fuzzy pert fuzzy input data task durations alternative approach furthermore authors propose various membership functions representation fuzzy task duration accordance nature task approach intended give realistic results tools operation possibilistic mean possibilistic variance fuzzy numbers possibilistic method acts defuzzification method results crisp value outcome task times earliest latest start earliest latest finish floats total free safety authors also base study estimates experts project scheduling experienced time management practical application also provided better comprehension proposed method american society civil engineers
jute based geotextile substitute synthetic geotextiles reviewed study importance advantage disadvantage jute based geotextile highlighted geotextiles permeable fabrics used association soil ability separate filter reinforce protect drain degrading condition environment presence non biodegradable residues geotexties pollutant caught attention scientific researchers ecological sustainability environment become one prime issues modem developmental strategy jute fibre found alternate potential geotextile material studies shown lifespan engineering properties jute based geotextiles suitably modified suit intended use
bent functions maximally nonlinear boolean functions even number variables attracted lot research four decades sake interesting combinatorial objects also relations coding theory sequences applications cryptography domains design theory paper investigate explicit constructions bent functions linear elements spreads presenting overview topic study bent functions linear elements presemifield spreads give explicit descriptions functions known commutative presemifields direct connection bent functions linear elements desarguesian spread oval polynomials finite fields proved carlet second author recently nice extensions made carlet another context introduce oval polynomials semifields dual symplectic semifields particular shown linear oval polynomial semifield one get oval polynomial transposed semifield
countries affected climate change nicaragua adaptation technologies promoted twofold aim securing livelihoods rural women men reducing climate related risks face although researchers practitioners usually aware every technology may beneficial sufficiently take account injustices adaptation technologies could produce inspired works feminist scholars engaged field science technology studies sts article attempts demonstrate need broaden debate gender sensitive climate change adaptation technologies argue first foremost debate must question potentially oppressive effects climate change narratives call technological solutions second urge feminist researchers practitioners denounce counter productive effects adaptation technologies impede transformation traditional gender roles based ethnographic fieldwork rural nicaragua article calls rethinking role climate change adaptation technologies offering possibilities challenging gender inequalities
recently fractional order proportional integral derivative fopid controllers demonstrated general form classical proportional integral derivative pid using fractional calculus fopid controller orders derivative integral portions integers offer flexibility succeeding control objectives paper proposes multi objective genetic algorithm moga optimize fopid controller gains enhance ride comfort heavy vehicles usage magnetorheological damper seat suspension system provides considerable benefits area proposed semi active control algorithm consists system controller determines desired damping force using fopid controller tuned using moga continuous state damper controller calculates input voltage damper coil mathematical model six degrees freedom seat suspension system incorporating human body model using damper derived simulated using matlab simulink software proposed semi active seat suspension compared classical pid optimum pid tuned using genetic algorithm passive seat suspension systems predetermined chassis displacement system performance criteria examined time frequency domains order verify success proposed fopid algorithm simulation results prove proposed fopid controller seat suspension offers superior performance ride comfort integer controllers
background response poor healthcare quality outcomes rising costs healthcare reform triple aim increased requirements providers demonstrate value payers partners public objective electronically automating measurement meaningful impact palliative care programs clinical operational financial systems time imperative success field goal development automated scorecard design scorecard organized format quality measures identified measuring matters mwm project defined important team automatically extracted electronic health record valid impacted time setting scorecard initially created using university florida health data new program successfully applied implemented university colorado anschutz medical campus second institution mature program measurements clinical metrics organized scorecard based mwm described terms metric definition rationale selection measure type structure process outcome whether represents direct proxy measure results conclusions process constructing scorecard helped identify areas within systems potential improvement team structure clinical processes outcomes addition automating data extraction scorecard decreases costs associated manual data entry extraction freeing clinical staff care patients increasing value delivered patients
different criminological theories assume religiosity protects violent behavior assumption tested empirically almost exclusively christian religiosity study presented questions whether relationship religiosity violent behavior could found muslims likewise using german wide representative school survey male students ninth grade belong either christian islamic denomination revealed christians higher religiosity correlates lower rate violent behavior influence christian religiosity explained mainly control theory variables muslims significant correlation religiosity violent behavior bivariate analysis multivariate analysis however reveals suppression effect controlling alcohol consumption muslim religiosity increases violent behavior addition high religious muslims agree often norms masculinity consume often media violence risk factors violent behavior accordingly concluded religiosity violence protecting factor general instead differentiated view separate religious groups necessary
three dimension fast low angle shot magnetic resonance imaging flash sequence widely adopted medical diagnostic imaging availability simplicity high spatial resolution improve quality structural brain images acquired flash sequence developed parameter optimization scheme image inhomogeneity correction methods optimal imaging parameters determined maximizing gray matter white matter cnr efficiency compared protocols based published parameters applying proposed optimal imaging parameters increased cnr efficiency image inhomogeneity including signal cnr inhomogeneity corrected choice optimal flip angle estimated transmit function estimated receive sensitivity result optimization image homogeneity correction greatly improved quality images acquired flash sequence published elsevier inc
work hypothesis structural health monitoring architectural heritage masonry exposed collapse risk city naples analyze collapse mechanisms static terms relating planimetric layout underground cavities naples recent collapses structures occurred city present work focuses relationship collapses presence underground cavities constructions masonry contrary common opinion structures provide comparatively level safety depending strength materials construction techniques adopted together fact able settle find new equilibrium configuration words embody prototype resilient structures main critical issue able put crisis huge masonry building subsoil subsidence fact structure reaches collapse creation cavities chasms literally remove support surface foundation particular present work aims analyze collapse two buildings department veterinary medicine federico occurred naples last december starting real case collapse masonry building research aims correlate collapse one cavities present subsoil naples evaluate possibility cause collapse related corresponding cavity newly formed situated corner building effect possible retrofitting intervention consisting three frp strips glued surface structure also considered elsevier ltd rights reserved
objectives model month rehospitalization risk among medicare beneficiaries receiving inpatient rehabilitation spinal cord injury sci traumatic brain injury tbi create sci tbi specific interactive tools enabling users generate monthly projected probabilities rehospitalization basis individual patient clinical profile discharge inpatient rehabilitation design secondary data analysis setting inpatient rehabilitation facilities participants medicare beneficiaries receiving inpatient rehabilitation sci tbi interventions applicable main outcome measures monthly rehospitalization yes based medicare claims results results summarized computer generated interactive tools plot individual level trajectories rehospitalization probabilities time factors associated probability rehospitalization time also provided different combinations factors generating different individual level trajectories four case studies presented demonstrate variability individual risk trajectories monthly rehospitalization probabilities individual high risk tbi sci cases declined respectively time whereas probabilities individual low risk cases much lower stable time respectively conclusions rehospitalization undesirable multifaceted health outcome classifying patients meaningful risk strata different stages recovery positive step forward anticipating managing unique health care needs time
discrete multiple signal classification music low computational cost mild condition requirement becomes significant noniterative algorithm joint sparse recovery jsr however fails rank defective problem caused coherent limited amount multiple measurement vectors mmvs letter provide novel sight address problem interpreting jsr binary classification problem respect atoms meanwhile music essentially constructs supervised classifier based labeled mmvs performance heavily depend quality quantity training samples viewpoint develop semisupervised music music spirit machine learning declares insufficient supervised information training samples compensated unlabeled atoms instead constructing classifier fully supervised manner iteratively refine semisupervised classifier exploiting labeled mmvs reliable unlabeled atoms simultaneously way required conditions iterations greatly relaxed reduced numerical experimental results demonstrate music achieve much better recovery performances music extended algorithms well typical greedy algorithms jsr terms iterations recovery probability
mucormycosis invasive infection caused opportunistic fungi rhizopus lichtheimia mucor rhizomucor common isolated genera primary cutaneous mucormycosis usually related traumatic injuries immunocompromised cases associated underlying conditions diabetes mellitus malignancies treatment choice surgical debridement liposomal amphotericin present year old male fever painful necrotic lesion middle back history poorly controlled diabetes mellitus rhizopus oryzae isolated identified using internal transcribed spacer regions initial good response treatment observed however days later diabetic ketoacidosis due poor adherence treatment caused lethal outcome
rainwater harvesting rwh systems recycle reuse runoff meet demand rwh may also provide additional benefit runoff reduction capture studies rwh focused upon water supply exclusively evaluate decentralized rwh systems across wide range land uses locations virginia water supply runoff capture using rainwater analysis simulation program rasp model rasp simulates rwh system using storage volume roof area irrigated area indoor nonpotable demand inputs lifecycle cost benefit model rwh developed water supply runoff capture reliability assessed simulation near optimal solutions identified case location using nonlinear metaheuristic algorithm positive net benefits achieved land use cases locations distinct differences observed reliability target achieved nearly commercial office high density residential cases also lowest runoff capture unit costs cases water supply reliability binding statistical analysis indicated costs variability characterized two locations virginia water supply runoff capture three locations necessary within specific locations land uses could combined cost effectiveness analysis land use provided means identifying least cost solutions water supply runoff capture net benefits found sensitive water wastewater charges elsevier ltd rights reserved
article based discourse analysis polish sexological publications well ethnographic fieldwork among contemporary sex experts publications sustaining called traditional gender roles perceived necessary condition good sex life women emancipation presented obstacle process time sex presented important element personal marital social happiness detailed guidelines achieve provided article focuses mechanism construction sexual scientific knowledge shows specific historical development sexology poland sexology developed interdisciplinary field sexuality perceived embedded socio cultural context approach established foundations contemporary sexological discourses analysis sexological publications placed context changing cultural political situation socialist poland one hand communist party promoted women full employment supported traditional marriage gender roles causing women double burden postsocialist period tension reinforced neoliberal gender sexual ideology article highlights interactions sexologists patients groups feminists emphasizes patients agency processes knowledge construction
thyroid hormones one key factors normal prenatal development mammals previously showed subclinical maternal hypothyroidism leads premature atresia ovarian follicles female rat offspring pre pubertal pubertal periods influence decreased concentration primordial follicles pool formation neonatal early infantile period rat pups investigated previously maternal hypothyroidism pregnancy irreversible negative influence primordial follicles pool formation population resting oocytes female rat offspring study done neonatal early infantile control hypothyroid female rat pups derived control propylthiouracil ptu treated pregnant dams respectively ovaries pups removed processed light transmission electron microscopy tem number nests oogonia oocytes per nest primordial primary secondary preantral follicles determined screening overall calcium presence ovarian tissue done using alizarin red staining morphology volume density nucleus mitochondria smooth endoplasmic reticulum ser oocytes primordial follicles also assessed caspase terminal deoxynucleotidyl transferase dutp nick end labelling tunel markers apoptosis proliferating cell nuclear antigen pcna proliferation determined oocytes granulosa cells different type follicles neonatal period ovaries hypothyroid pups decreased number oogonia oocytes nests increased number primordial follicles decreased number primary secondary follicles early infantile period increased number primary secondary preantral follicles found alizarin red staining intense hypothyroid neonatal rats also highest content dilated ser number mitochondria altered morphology groups hypothyroid pups increased apoptosis markers shown significant difference groups pcna increased expression oocytes granulosa cells primordial follicles hypothyroid rats light electron microscopy analysis indicate previously detected premature ovarian follicular atresia pre pubertal pubertal hypothyroid rats preceded premature formation primordial follicles followed slight changes ser mitochondria examined oocytes increased expression pcna elsevier ltd rights reserved
thiamine vitamin factor three pivotal enzymes glycolytic metabolism pyruvate dehydrogenase alpha ketoglutarate dehydrogenase transketolase thiamine deficiency leads neurodegeneration several brain regions especially cerebellum addition several neurodegenerative diseases associated impairments glycolytic metabolism including alzheimer disease therefore understanding link dysfunction glycolytic pathway neuronal death important step comprehend mechanism progression neuronal degeneration well development new treatment neurodegenerative states using vitro model study effects thiamine deficiency cerebellum granule neurons show increase current density expression results indicate link alterations glycolytic metabolism changes dynamics two factors implicated neurodegeneration
biomimetics applies principles strategies abstracted biological systems engineering technological design huge potential innovation biomimetics could evolve key process businesses yet challenges remain within process biomimetics especially perspective potential users work clarify understanding process biomimetics therefore briefly summarize terminology biomimetics bioinspiration implementation biomimetics requires stated process therefore present model problem driven process biomimetics used problem solving activity process biomimetics facilitated existing tools creative methods mapped set tools biomimetic process model set assessment sheets evaluate theoretical practical value tools analyzed tools interdisciplinary research workshops present characteristics tools also present attempt utility tree finalized could used guide users process choosing appropriate tools respective expertize aim paper foster dialogue facilitate closer collaboration within field biomimetics
jakvf mutation results hyper activation jak kinase erythropoietin pathway molecular marker myeloproliferative neoplasms using allele specific real time pcr detected mutation blood normal donors mutant allele burden however low polycythemia vera much higher differentiated blood cells peripheral blood undifferentiated cells erythropoietin stimulated differentiation normal cells liquid culture increased mutation frequency fold progenitors normal donors grown erythropoietin stimulated semi solid cultures mutation found colonies jak alleles positive colony suggesting mutation occurred cells per colony mouse erythroleukemia cells carrying human jak dna wild type jakvf frequencies mutations jak wild type jakvf vice versa increased following erythroid differentiation results suggest mutation occurs accumulates differentiation hypothesize genetic stability relies dna repair efficient normal hematopoietic stem cells downgraded differentiating cells rendering susceptible mutations including jakvf elsevier inc rights reserved
purpose retrospective cohort study designed evaluate clinical performance ceramicveneered zirconia frameworks materials methods patients recruited according defined inclusion criteria patients checked every months time definitive rehabilitation end patients rescheduled rechecked study purposes restorative procedures assessment performed previously established methods primary outcomes survival success rates prosthesis descriptive statistics used patient demographics implant distribution occurrence complications study survival success prostheses cox regression analysis used model constructed forward conditional stepwise mode predictive variables included model adjusted survival curves obtained outcome results patients rehabilitated implant supported screw retained full arch ceramic veneered zirconia framework rehabilitations range follow months years full implant supported screw retained full arch rehabilitations cox regression analysis indicated within year time frame probability framework fracture major chipping minor chipping former combined occur respectively conclusion results suggest zirconia suitable material framework structure implant supported full arch rehabilitations however experiences high incidence technical complications mainly due ceramic chipping clinical studies aim ascertain effects clinical features manufacturing procedures survival rates prostheses
objectives quantify impact image optimization absorbed radiation dose associated risk children undergoing cardiac catheterization background various imaging fluoroscopy system technical parameters including camera magnification source image distance collimation antiscatter grids beam quality pulse rates affect radiation dose well studied younger children methods used anthropomorphic phantoms ages newborn years old measure surface radiation exposure various imaging approaches estimated absorbed organ doses effective doses using monte carlo simulations models developed national academies biological effects ionizing radiation vii report used compare imaging protocol optimized dose reduction versus suboptimal imaging source image distance magnification setting collimation lifetime attributable risk lar cancer results newborn year old phantoms respectively changes follows increase inch inch camera magnification increase source image distance addition inch periphery collimation removal antiscatter grid compared optimized protocol suboptimal imaging increased fold newborn fourfold years old estimated cancer lar min posteroanterior fluoroscopy using optimized versus suboptimal imaging respectively versus newborn female versus newborn male versus year old female versus year old male conclusions radiation related risks children undergoing cardiac catheterization substantial markedly reduced optimized imaging approach wiley periodicals inc
paper report differentiating properties platelet rich plasma releasates prpr human chondrocytes within elastomeric polycaprolactone triol citrate pclt porous scaffold human derived chondrocyte cellular content glycosaminoglycans gags total collagen determined seeding pclt scaffold enriched prpr cells immunostaining real time pcr applied evaluate expression levels chondrogenic extracellular gene markers seeding chondrocytes pclt scaffold enriched prpr showed significant increase total collagen gags production compared chondrocytes grown within control scaffold without prpr cells mrna levels collagen sox increased significantly upregulation cartilage oligomeric matrix protein comp expression statistically insignificant also report reduction expression levels collagen iii chondrocytes consequence proximity prpr cells within scaffold interestingly pre loading prpr caused increase expression levels following extracellular matrix ecm proteins fibronectin laminin integrin beta period days overall results introduce pclt elastomeric scaffold new system cartilage tissue engineering method prpr cells loading prior chondrocyte culture could considered potential environment cartilage tissue engineering differentiation ecm formation enhanced significantly
although strobilurins one effective broad spectrum classes systemic fungicides may also increase plant stress tolerance modulating activity antioxidant enzymes address issue effect azoxystrobin activity antioxidant enzymes concentrations antioxidant metabolites oxidative stressrelated compounds studied rice plants metica either inoculated bipolaris oryzae causal agent brown spot minimally affected enzyme activities consistently increased glutathione reduced gsh concentrations noninoculated plants activities superoxide dismutase peroxidase ascorbate peroxidase glutathione peroxidase glutathione reductase glutathione transferase increased upon oryzae infection increases greatly limited sprayed plants catalase activity decreased inoculated plants compared noninoculated plants regardless fungicide treatment gsh concentration increased response oryzae infection sprayed plants sustained higher levels gsh advanced stages fungal infection nonsprayed plants inoculated plants exhibited extensive oxidative stress evidenced higher concentrations hydrogen peroxide malondialdehyde compared noninoculated plants lower later increases recorded sprayed plants nonsprayed plants therefore greatly reduces oryzae induced oxidative stress limiting development rather activating antioxidant enzymes gsh however seems modulated may partially explain constrained oxidative stress observed sprayed plants
laparoscopic surgery complex minimum invasive operation requires long learning curve new trainees adequate experience become qualified surgeon development virtual reality technology virtual reality based surgery simulation playing increasingly important role surgery training simulation laparoscopic surgery challenging involves large non linear soft tissue deformation frequent surgical tool interaction complex anatomical environment current researches mostly focus specific topics deformation collision detection rather consistent efficient framework direct use existing methods achieve high visual haptic quality satisfactory refreshing rate time especially complex surgery simulation paper proposed set tailored key technologies laparoscopic surgery simulation ranging simulation soft tissues different properties interactions surgical tools soft tissues rendering complex anatomical environment compared current methods tailored algorithms aimed improving performance accuracy stability efficiency perspectives also abstract design set intuitive parameters provide developers high flexibility develop simulators copyright john wiley sons ltd
mindfulness training appears reduce stress distress little known whether results changes observed colleagues family friends appropriateness workplace stress management intervention large distributed public sector workforce study evaluated pilot week mindfulness work program mawp acceptability feasibility efficacy relation stress related mental health productivity problems public sector employees parallel group randomized controlled trial compared mawp intervention information control exploratory qualitative quantitative methods used assess changes observed informants results suggest high degree acceptability although location inflexible work schedules presented feasibility obstacles compared control primary outcome mindfulness improved mawp participants perceived stress psychological distress health related quality life social functioning secondary outcomes least partly mediated changes mindfulness intervention thus appears potential merit workplace intervention public sector employees across range outcomes obtaining informant observations feasible qualitative analyses indicated positive changes supported self reported outcomes quantitative analyses returned ambiguous results seven item scale adapted popular self report mindfulness scale use informants showed promise work needed establish validity reliability scalability method assessing observable changes following mindfulness training
paper discusses performance solar assisted ground source heat pump sagshp system used storage solar energy day time space heating night experiments conducted estimate effectiveness solar energy storage ground using tube ground heat exchanger absorbing solar energy utilize stored energy space heating night time using experimental data heat absorbed solar collector heat injected ground heat extracted ground cop system computed results indicate heat absorption solar collector varied increase mass flow rate due heat losses solar heat could injected ground day time increase mass flow rate heat transfer fluid collector ground heat exchanger resulted increase heat injection ground due charging ground thermal energy times work input solar collector could extracted additionally ground night time space heating charging ground resulted increase cop system space heating night time elsevier rights reserved
monocytes patients ankylosing spondylitis toll like receptor tlr overexpression monocytes myeloid related protein mrp protein complexes calcium binding proteins act endogenous ligands tlr thus studied levels mrp adult patients mrp levels assessed adult patients satisfying assessments ankylosing spondylitis international society criteria healthy controls elisa patient disease parameters like patient physician global assessment bath ankylosing spondylitis disease activity index basdai swollen tender joint count entheseal count maastricht enthesitis index erythrocyte sedimentation rate esr reactive protein crp also recorded levels reassessed patients months treatment nsaids values median iqr serum mrp levels patients significantly higher healthy controls iqr patients peripheral arthritis higher levels pure axial disease iqr levels mrp correlated disease activity score das crp crp correlation better early disease years disease duration respectively baseline levels higher treatment responders non responders change mrp levels correlated change basdai asdas crp respectively mrp levels may used biomarker activity peripheral arthritis response therapy
background infants weeks gestation exposed topical iodine avoidance recommended pregnancy breast feeding exposure contrast media topical iodine frequently used many preterm neonates aim determine whether thyrotropin levels preterm infants affected exposure intrapartum neonatal topical iodine use iodinated contrast media design infants weeks gestation recruited maternal neonatal exposures iodinated contrast media topical iodine recorded levels thyrotropin thyroxine measured blood spot cards postnatal days equivalent weeks gestation results one hundred twenty five infants exposed topical iodine contrast media infants unexposed infants treated hypothyroidism three infants exposed group transient hyperthyro tropinaemia mean thyrotropin levels significantly higher postnatal days infants exposed topical iodine prior caesarean section compared unexposed infants relationship persisted adjustment conclusions context study neonatal thyroid dysfunction seen following exposure iodine via caesarean section via exposure contrast media
locus control one widely studied concepts history personality psychology spite popularity associations numerous relevant outcomes ability locus control predict future behaviors involving parenting effectiveness researched parent locus control children outcome studies characterized cross sectional methodologies focus mothers present study uses prospective methodology compare data mothers fathers locus control child behavior outcomes large scale research project avon longitudinal study parents children alspac based rotter social learning theory published past empirical research predicted found parent internality associated positive child outcomes parent externality specifically parents internal children positive outcomes sleeping eating tantrum behavior compared parent locus control combination however external parents less restrictive attitude appeared beneficial effect picky eating results confirmed important parent locus control lives children based findings researchers urged develop interventions change advice parents promote internal locus control among parents
applications computer graphics bidirectional texture function btf used realistic predictive rendering goal current research get surface representation indistinguishable real world developed built tested portable instrument btf acquisition based kaleidoscopic imaging discuss color issues experienced initial tests show color balance applied whole image spectral response instrument varies depending position within image optical elements inspected contributions spectral behavior instrument software simulator mathematical model device implemented found way implement contributions image processing pipeline way correct white balance individual pixel image found applied allowing faithful color representation also proposed optimized dielectric protective layer kaleidoscope mirrors causing least possible color aberration society photo optical instrumentation engineers spie
interleukin axis strongly implicated pathogenesis psoriasis previous studies showed elevated early active progressive plaque type psoriatic lesions serum plasma levels correlated psoriasis area severity index however mechanism whereby affects disease severity remains unknown study investigated effects psoriasis like skin inflammation model induced recombinant mouse found cooperatively induced prominent inflammation enhanced psoriasis like epidermal hyperplasia skin mice treated plus expression interferon gamma significantly upregulated chemokine motif ligand cxcl synergistically increased histologically strong positive signals cxcl observed around infiltrating inflammatory cells current results suggest might synergize induce helper immune reaction without inhibiting axis thus may aggravate psoriatic inflammation
concept data structure part accepted relatively unexplored background information disciplines data structure treated largely technological artefact helping support somewhat isolated considerations institutional order paper develops alternative consideration data structure focuses upon constitutive capacity artefacts within institutional order viewpoint builds upon literature language action tradition recent work john searle social ontology well small amount work proposes actability data structures help provide grip slippery notion institutional order consider terms notion business patterns term business pattern used refer coherent repeating sequence action involving humans machines including systems artefacts data structures appropriate way organising paper also describes way visualising either existing business patterns envisaged business patterns pattern language pattern comics ground approach using material gathered within research study key routine enacted within large manufacturing organisation within routine mismatch experienced data structures within production system telling production managers experienced ground production operators show actability worldview data structures expressed terms business patterns offers fruitful way making sense problem situations also suggests important ways thinking differently nature design relation data structures author published elsevier ltd
despite important theoretical applied implications limited experimental research investigating influence emotional valence young children verbal recall everyday emotional experiences issue addressed current study specifically investigated young children years recall emotional experiences presented six brief stories address methodological limitations small body existing literature adopted within participants design story content matched valence positive negative neutral counterbalanced across stories fifty four children presented six stories via narrated slideshow recall assessed delay results showed emotional stories better recalled neutral stories negatively valanced stories better recalled positively valanced stories recall advantage negatively valanced information found aspects story suggesting negative valence renders events particularly memorable society applied research memory cognition published elsevier inc rights reserved
background retrospective parental reports often used identify early characteristics children later diagnosed developmental disorder method applied methodology document parents initial concerns development children later diagnosed fragile syndrome fxs parents additionally asked noticed emergence behavioural signs related fxs results half parents reported initial concerns prior child first birthday cases atypical motor behaviours caused first concerns behavioural signs related fxs phenotype also reported perceptible first year child life conclusions due limitations retrospective parental questionnaires suggest methodologies home video analysis needed complement understanding pathways developmental disorders late clinical onsets
modeling approach based domain partitioning use electromagnetic circuit formulation full wave electromagnetic field applied high frequency integrated passive components including mems switches procedure completed model order reduction generation small compact model describes high accuracy input output behavior device main benefit approach allows saving computational resources used refine complicated part domain thus obtain accurate model full device procedure validated real benchmarks measurements available well mems switch test described literature
radio frequency spectrometer rfs two channel digital receiver spectrometer make remote sensing observations radio waves situ measurements electrostatic electromagnetic fluctuations solar wind part fields suite solar probe plus spp rfs optimized measurements inner heliosphere solar radio bursts intense plasma frequency higher compared previous measurements distances greater inputs rfs receiver four electric antennas mounted near front spp spacecraft single axis spp search coil magnetometer scm rfs channel selects monopole dipole antenna input scm input via multiplexers primary data products rfs autospectra cross spectra selected inputs spectra calculated using polyphase filter bank enables measurement low amplitude signals interest presence high amplitude narrowband noise generated spacecraft systems discuss science signals interest driving rfs measurement objectives describe rfs analog design digital signal processing show examples current performance plain language summary solar probe plus spp nasa mission travel much closer sun previous spacecraft fields experiment spp composed sensors antennas magnetometers receivers measure electric magnetic fields unexplored region paper describes radio frequency spectrometer rfs receiver measure radio waves mhz describe types radio signal sources present interplanetary space close sun show design rfs makes possible measure sources demonstrate current performance receiver
propose coefficients assumed similarity acquaintance ratings based actual similarity observer target rather bias project self onto assessed assumed similarity actual similarity rater accuracy university roommate dyads rated personality related variables findings indicate roommates actually alike many variables knew rather assumed applied knowledge enhance accuracy ratings outline model judgment urges three distinct concepts true assumed similarity known similarity spurious similarity conclude personality ratings among acquaintances reflecting true assumed similarity probably rare elsevier inc rights reserved
mesenchymal stromal cells mscs committed progenitors mesodermal origin found virtually every organ exhibit multilineage differentiation osteocytes adipocytes chondrocytes mscs also mediate wide spectrum immunoregulatory activities usually dampen innate adaptive immune responses features attracted interest perspective developing novel cell therapies autoimmune disease however depending microenvironmental conditions mscs may show plastic behavior switch immunostimulatory phenotype thorough characterization effects mscs immune system msc cell therapy tested animal models autoimmunity using different cell sources protocols vitro expansion routes schedules administration pre clinical results encouraging models crohn disease multiple sclerosis heterogeneous others graft versus host disease systemic lupus erythematosus rheumatoid arthritis clinical trials carried many ongoing discussed results obtained preliminary draw conclusion exception topical administration mscs proven efficacious mechanism action infused mscs still investigation apparent paradox therapeutic effect achieved spite low number cells reaching target organ solved finding msc derived extracellular vesicles evs closely mimic therapeutic activity mscs pre clinical models issues critically discussed view potential clinical use msc derived evs
background purpose study describe known hiv infection sexually transmitted diseases infection transmission routes care sources information viewpoint men sex men methods national data collected june august finland part joint internetbased survey conducted countries emis european msm internet sex survey results respondents age place residence highest education employment status statistically significantly related often respondent sought information hiv testing treatments knew infection transmission routes respondents information seeking behavior seen active regarding hiv infection sexually transmitted diseases conclusions also consider possibility using internet based interventions especially smaller northern catchment areas order improve knowledge level men sex men
rolling stock examination performed identify defects train movements speeds kmph study process automated using computer vision models parts moving train segmented using four types active contour level set models chan vese based morphological differential gradient mdg shape priors shape invariance level sets shape invariance model enables adjustment contour according scale rotation location shape prior object rolling stock frame train rolling stock video data captured high speed fps using sports action camera degrees wide angle lenses level sets yielded optimal segmentation results compared traditional segmentation methods performance indicators segmented parts proposed four algorithms structural similarity index measure peak signal noise ratio total parts extracted bogie using proposed models compared ground truth models test performance methods train passenger cars bogies furthermore models tested various lighting conditions five trains shape invariance model yielded efficient segmentations qualitatively quantitatively
need store manipulate large volume unstructured data led development several nosql databases better scalability graph databases particular kind nosql databases proven efficiency store query highly interconnected data become promising solution multiple applications mapping conceptual schemas relational databases well studied field research solutions target conceptual modeling nosql databases even less focusing graph databases specially true dealing mapping business rules constraints conceptual schema article describe mapping uml ocl conceptual schemas blueprints abstraction layer top variety graph databases gremlin graph traversal language via intermediate graph metamodel tool support fully available
paper presents different state feedback approaches finite control set model predictive control fcs mpc applied grid connected voltage source converter vsc lcl filter besides converter side current feedback two multivariable control approaches line side current control introduced compared based theoretical experimental evaluation lcl filter introduces additional resonance frequency system use different active damping methods combination fcs mpc discussed furthermore practical control implementation issues discussed presented methods reveal great potential high dynamic performance flexibility fcs mpc enabling multivariable control well reduced switching losses low harmonic current distortion time eventually feasibility theoretical control concepts shown laboratory environment
sewing needles rare causes penetrating cardiac injury suicidal attempt accidental penetration domestic violence child abuse likely causes injury owing sharp nature needles rapidly migrate tissues fatalities due cardiac tamponade infection peripheral embolism valve dysfunction
paper proposes forecast indicators ukrainian cargo transport system taking account relations macroeconomic indicators increased forecast accuracy priori information uncertainty attained optimization technique starting vector autoregression var model observed multiple time series state space representation subsequent adaptive filtering adaptive filter earlier proposed authors minimizes forecasting errors optimization criterion information divergence kullback leibler probability distributions real values estimations established main advantage proposed technique connected opportunity estimate future values multiple time series even presence structural breaks describing changes status crisis crisis observations available analysis performed period sample forecasting multiple time series cargo volumes transferred different transport modes two macro indicators compared forecast based var model sample forecast realized last three months
objective examine relationships spirituality physical activity sedentary behavior sample latino adults massachusetts design cross sectional analysis lawrence health well study study conducted among patients greater lawrence family health center glfhc lawrence massachusetts participants latino hispanic adults aged years completed study results significant negative relationship spirituality sedentary behavior beta although statistically significant higher spirituality associated increased odds engaging physical activity significant associations spirituality physical activity among men women men greater spirituality significantly less sedentary beta relationship sedentary behavior spirituality among women conclusions study found individuals spiritual also less sedentary association stronger men women findings provide insight developing future interventions promote activity high risk population greatly understudied future research endeavors consider investigating impact spirituality based messages reduce sedentary behavior among latinos
drosophila served model research innate immunity decades however knowledge post transcriptional regulation immune gene expression micrornas mirnas remains rudimentary present study using small rna seq bioinformatics analysis identified differentially expressed mirnas drosophila infected escherichia coli compared injured flies three time points furthermore found mirnas potentially involved regulation imd pathway related genes strikingly based uas mirnas line screening dualluciferase assay identified mir mir could negatively regulate drosophila antibacterial defenses decrease level antibacterial peptide diptericin taken together data support involvement mirnas regulation drosophila imd pathway elsevier ltd rights reserved
background postdural puncture headache pdph mainly resulting loss cerebral spinal fluid csf well known iatrogenic complication spinal anesthesia diagnostic lumbar puncture spinal needles modified minimize complications modifiable risk factors pdph mainly included needle size needle shape however whether incidence pdph significantly different cutting point pencil point needles controversial meta analysis assess incidence pdph cutting spinal needle pencil point spinal needle methods included randomly designed trials assessing clinical outcomes patients given elective spinal anesthesia diagnostic lumbar puncture either cutting pencil point spinal needle eligible studies selected studies risk bias assessed investigators clinical outcomes including success rates frequency pdph reported severe pdph use epidural blood patch ebp recorded primary results results evaluated using risk ratio confidence interval dichotomous variables rev man software version used analyze appropriate data results twenty five randomized controlled trials rcts included study analysis result revealed pencil point spinal needle would result lower rate pdph severe pdph furthermore ebp less used pencil point spine needle group conclusions current evidences suggest pencil point spinal needle significantly superior compared cutting spinal needle regarding frequency pdph pdph severity use ebp view recommend use pencil point spinal needle spinal anesthesia lumbar puncture
objective study assess overall health including sexual reproductive health srh knowledge needs sexual behaviors testicular health practices among young minority males anonymous questionnaires administered year old males receiving services health clinics large southwestern city survey completed males mean age years young males identified african american hispanic results suggest study participants lack srh knowledge related pregnancy condom effectiveness engage risky sexual behavior including using birth control last sexual encounter although participants sexually transmitted infection sti past year approximately perceived sti hiv risk low low respondents low engagement lack knowledge testicular health practices majority respondents reported physical fight one times reported victims intimate partner violence data support need comprehensive health services minority young males
runjags package provides set interface functions facilitate running markov chain monte carlo models jags within automated calculation appropriate convergence sample length diagnostics user friendly access commonly used graphical outputs summary statistics parallelized methods running jags provided template model specifications generated using standard lme style formula interface assist users less familiar bugs syntax automated simulation study functions implemented facilitate model performance assessment well drop type cross validation studies using high performance computing clusters provided parallel module extension jags also included within runjags providing pareto family distributions series minimally informative priors including dumouchel half cauchy priors paper outlines primary functions package gives illustration simulation study assess sensitivity two equivalent model formulations different prior distributions
part transmission network expansion planning tnep technical economical assessment several planning alternatives must performed order ensure fulfillment network security criteria estimate alternatives expected operating costs task requires performing load flow calculations different operating points ops power system due high computational burden considering possible ops simply possible consequence set representative ops usually taken account mostworks tnep focus issues related optimization algorithms modeling neglecting selection process representative ops furthermore works consider ops providing little insight criteria used selection process error made evaluating planning alternatives using limited number ops work novel methodology selecting representative ops consider within tnep presented proposal pays special attention critical situations network security may endangered furthermore methodology allows quantifying error made evaluating network operation using limited number representative ops
paper inkjet printed paper based capacitive touchpad proposed touchpad detects finger contact sensing change effective capacitance caused skin electrical impedance low cost flexible disposable touchpad nine capacitive buttons fabricated using paper substrate use home inkjet printing technology silver nanoparticle ink makes fabrication process simple fast cheap environmentally friendly performance proposed touchpad measured microcontroller tests conducted cases finger touch pen operation measured capacitance non touched state whereas themeasured capacitance touched state differences capacitance state sufficiently large indicate finger made contact touchpad sensitivity proposed sensor evaluated parameters proposed sensor compared paper based touch pads
design new hybrid type digital pulsewidth modulator dpwm wide frequency range khz mhz presented proposed dpwm maximum duty cycle resolution bits consumes power khz mhz respectively proposed dpwm realizes upper bit resolution using programmable digital counter lower bit resolution using current integrating type phase interpolator employing ladder current steering digital analog converter low power consumption operating clock generated chip using relaxation oscillator prototype integrated circuit fabricated high voltage complementary metal oxide semiconductor demonstrates proposed dpwm maintains good linearity across entire operating range
beta form crystals isotactic polypropylene ipp proved favorable effective developing general ipp plastics high performance herein sustainable eggshell power decorated calcium pimelate des effective beta form nucleating agent ipp fabricated via interaction pimelic acid surface eggshell powder elevated temperature dsc ftir analysis identified reaction occurred formation calcium pimelate surface eggshell powder effects functionalized eggshell powder nonisothermal isothermal crystallization behavior melting characteristics polymorph structures investigated nonisothermal crystallization experiments incorporation supported beta form nucleator greatly enhanced crystallization temperature ipp content beta form crystals beta could reach value high mass des load moreover crystallization melting characteristics ipp nucleated des changed multiple scan conditions melt temperature range degrees interestingly investigation isothermal crystallization subsequent melting behavior found des temperature dependent selective nucleator inducing ipp crystallization main alpha form crystals beta form crystals could form using high low crystallization temperatures respectively particularly results demonstrated possibility tailor ratio alpha form crystals beta form crystals simply choosing isothermal crystallization conditions crystallization mechanism based thermodynamics kinetics factors discussed
comprehensive ontology ease discovery maintenance popularization knowledge many domains means enhance existing ontologies attribute extraction attracted tremendous research attentions however existing attribute extraction techniques focus exploring single type sources structured relational databases semi structured extensible markup language xml unstructured sources web texts images leads poor coverage knowledge bases kbs paper presents framework ontology augmentation extracting attributes four types sources namely existing knowledge bases kbs query stream web texts document object model dom trees particular use query stream two major kbs dbpedia freebase seed attribute extraction web texts dom trees specially focus exploring extraction technique dom trees rarely studied previous works algorithms series filters developed experiments show capability approach augmenting existing ontology
manufacturing field happens products processed high speed production lines pass different machines order processed according pre established order resting moving supports usually stop process rather machines able track handle moving advantages kind process stem continuous motion product results increased productivity since downtime production consequence tracking goods widely adopted process manipulate package products reported literature strong effort directed development effective control system allowing synchronization operations detection position incoming products systems generally called cutting systems fly design setup systems critical tool simulate analyse behaviour machine article proposed systemic approach model main elements characterize systems aimed develop effective control strategy improve performance machine simulation tool allows predict behaviour machine test different control strategies
background childhood diseases atopic dermatitis negative impact quality life qol parents pediatric psoriasis affects parent qol unknown objective explore impact childhood psoriasis lives parents methods semistructured interviews conducted parents children psoriasis narrative data analyzed conceptual framework effects childhood psoriasis parents developed results parents reported child psoriasis caused substantial negative impact qol conceptual framework showed negative impact health self care emotional well family social function personal well life pursuits emotional well affected domain limitations possible correlate psoriasis severity parental qol conclusion childhood psoriasis alters qol parents multiple ways information study used develop qol instrument explore treatment support strategies families affected pediatric psoriasis
distribution network analyses traditionally carried sequentially processing computational tasks without taking advantage parallel processing available multi core machines however future distribution networks require studies cater uncertainties due location behavior loads low carbon technologies resulting much computationally demanding environment paper investigates adoption high performance computing hpc accelerate probabilistic impact control analyses carried residential low voltage networks electric vehicles evs first impacts uncontrolled charging evs quantified using monte carlo based approach using time series daily simulations per penetration level mitigate impacts coordinated management load tap changer evs proposed considering preventive control approach caters uncertainties ahead scenarios two real residential underground networks considering realistic demand load profiles min resolution analyzed results show processing time impact analysis reduced almost proportionally number cores control perspective demonstrated hpc feasible implementable alternative management future smart grids
case young male patient diagnosed hypophosphatemic osteomalacia ankylosing spondylitis assessed literature year old male patient previously diagnosed ankylosing spondylitis hypophosphatemic osteomalacia admitted clinic beginning disease complained pain first metatarsal bone low back sacroiliac magnetic resonance images interpreted sacroiliitis diagnosed referred many hospitals received several therapies benefit treatment complaints worsened human leukocyte antigen hla test negative alkaline phosphatase level high old femur fractures reported whole body bone scintigraphy addition patient diagnosed osteomalacia patient receiving vitamin oral phosphate anti tumor necrosis factor therapy added patient diagnosis reevaluated final diagnosis hypophosphatemic osteomalacia instead ankylosing spondylitis
background whether polyethylene tibial apt components beneficial patients received distal femur limb salvage surgery lacks high quality clinical follow mechanical evidence study aimed investigate biomechanics distal femur reconstructed apt tumor knee prostheses using finite element analysis based previous promising clinical outcome methods three dimensional models use apt metal backed tibial mbt prostheses reconstruct distal femoral bone defects developed input abaqus fea software version mesh refinement tests gait simulation single foot upright degrees flexion positions mechanical loading conducted stress distribution analysis compared apt mbt two static positions results prosthesis types stress concentrated junction stem shaft maximum stress femoral axis base mpa stress tibial surface relatively distributed mpa stress tibial bone cement layer apt prosthesis approximately times higher mbt prosthesis region stress proximal tibial cancellous bone cortical bone apt prosthesis times greater mbt prosthesis distributed conclusions although stress bone cement around apt component relatively high stress better distributed polyethylene cement bone interface apt mbt prosthesis effectively protects proximal tibia distal femur tumor knee prosthesis replacement results considered selecting appropriate tibial component patient especially foreseeable conditions osteoporosis
objectivesthe aim study identify systemic local risk indicators associated peri implantitis material methodsone hundred eighty three patients treated osseointegrated titanium implants function least year included present study implants installed foundation scientific technological development dentistry fundecto university sao paulo usp factors related patient systemic conditions heart disorders hypertension smoking habits alcoholism liver disorders hepatitis gastrointestinal disease diabetes mellitus hyperthyroidism hypothyroidism radiation therapy chemotherapy menopause osteoporosis active periodontal disease history periodontal disease bruxism implant characteristics location diameter length connection shape antagonist clinical parameters wear facets periodontal status adjacent tooth plaque accumulation adjacent tooth modified plaque index sulcus bleeding index probing depth bleeding probing width keratinized tissue marginal recession resultsan increased risk times history periodontal disease times cemented restorations compared screw retained prostheses times wear facets displayed prosthetic crown times total rehabilitations compared single rehabilitations found logistic regression analysis show association implant characteristics peri implantitis conclusionsa history periodontal disease cemented prostheses presences wear facets prosthetic crown full mouth rehabilitations identified risk indicators peri implantitis implants characteristics related presence peri implantitis
background imiquimod imq produces cutaneous phenotype mice frequently studied acute model human psoriasis whether phenotype depends strain sex never systematically investigated large scale effects however could lead conflicts among studies impacting study outcomes efforts translate research findings methods rna seq used evaluate psoriasiform phenotype elicited days aldara imq treatment sexes seven mouse strains cbl balb dba fvb svj molf eij results strains imq altered gene expression manner consistent human psoriasis partly due innate immune activation decreased homeostatic gene expression response molf males aberrant however decreased expression differentiation associated genes elevated strains key aspects imq response differed two commonly studied strains balb compared balb phenotype showed increased expression genes associated dna replication stimulation activated cells decreased expression genes associated interferon signaling cells although imq induced expression shifts mirrored psoriasis responses balb svj dba molf mice consistent human skin conditions wounds infections imq responses mice consistent human psoriasis best replicated expression patterns specific psoriasis lesions conclusions findings demonstrate strain dependent aspects imq dermatitis mice shown imq uniquely model psoriasis fact triggers core set pathways active diverse skin diseases nonetheless findings suggest mice provide better background strains modeling psoriasis disease mechanisms
background increasing body evidence suggested idiopathic pulmonary fibrosis inclined combine lung cancer recent years thus studied correlation two diseases raise awareness risk lung cancer pulmonary fibrosis patients among doctors patients methods data epidemiology pathogenesis clinical features treatment strategies idiopathic pulmonary fibrosis associated lung cancer cited review obtained major databases pubmed web science embase scoups cancerlit results prevalence rate lung cancer pulmonary fibrosis patients much higher general population perturbed signaling pathways epigenetic genetic changes oxidative stress thought involved pathogenesis idiopathic pulmonary fibrosis associated lung cancer hemoptysis chest pain alert presence lung cancer pulmonary fibrosis patients peripheral lower highly fibrotic regions common sites lung cancer adenocarcinoma squamous cell carcinoma common types idiopathic pulmonary fibrosis associated lung cancer patients treatment strategies including medication surgery controversial complex thorny conclusion idiopathic pulmonary fibrosis associated increased lung cancer risk necessary raise awareness lung cancer risk idiopathic pulmonary fibrosis patients research investigating pathogenesis idiopathic pulmonary fibrosis associated lung cancer could help develop newer therapeutic targets treatment idiopathic pulmonary fibrosis lung cancer
redundant nickel harmful human health result skin diseases allergies cancer although many probes based noble metal nanoparticles established rapid heavy metal ion detection naked eye ultraviolet visible vis spectroscopy noble metal nanomaterials developed detection study propose novel triangular silver nanoprisms agnprs stabilized glutathione gsh rapid colorimetric detection based sensing mechanism anti etching affirmed raman spectra vis spectra transmission electron microscopy dynamic light scattering optimal experimental parameters gsh agnpr based probe excellent selectivity compared ions inhibit agnpr etching iodide ion anti etching ions limit detection lod probe via naked eye via vis spectroscopy negligible compared permissible limit drinking water prescribed world health organization particular latter far lower lod values reported probes based noble metal nanomaterials satisfying linear relationship reinforces probe utilized quantitative analysis detection real water samples indicates probe could used rapid colorimetric detection supersensitivity excellent selectivity real environmental water samples
purpose last decades new evidences supported relationship polymorphisms susceptibility develop ligament tendon injuries performed review genetic factors involved tendon ligament injuries methods review literature performed systematic fashion using terms sports ligaments injuries tendon genetics pubmed embase cinahl cochrane medline google scholar databases screened years results genes currently associated tendon ligament injuries include gene encoding collagen tenascin matrix metallopeptidase growth factors conclusions tendon ligament injuries single genetic cause predictive genomics dna profiling athletic performance sport injuries allows understand genetic advantages exploited genetic barriers overcome although findings could explain individual able excel one sport discipline rather different one individual develops injuries another one many factors taken account indeed environment lifestyle play critical role combination gene profile determing tendon ligament injuries
water acetone extract icelandic brown algae fucus vesiculosus evaluated potential natural sources antioxidant compounds skin care emulsions assess efficacy inhibiting lipid oxidation caused photo thermoxidation stored darkness room temperature control conditions compared samples stored accelerated conditions light room temperature darkness degrees presence extracts skin care emulsions induced remarkable colour changes emulsions exposed light extensively high temperature high temperature also caused greater increments droplet size emulsions analysis tocopherol content peroxide value volatile compounds storage revealed whereas water acetone extracts showed emulsion protective effect thermooxidation water extract showed antioxidant activity photooxidation practical applications research basis developing natural antioxidants derived seaweed limit lipid oxidation skin care products
paper use car following model study electric vehicle trip cost total trip cost allowing late arrival numerical result show electricity cost great effects commuter trip cost total trip costs effects dependent commuter time headway origin electricity cost prominent impacts minimum value total trip cost commuter different time headway origin elsevier rights reserved
objective aim study identify prevalence metabolic syndrome mets degree cardiovascular disease cvd risk patients psoriatic arthritis psa material methods performed cross sectional study adult patients psa control group patients rheumatoid arthritis mets diagnosed according national cholesterol education program adult treatment panel iii ncep atp iii international diabetes federation idf criteria framingham risk scores year risk cvds coronary heart disease chd also calculated results prevalence mets higher patients psa according ncep atp iii respectively idf respectively criteria prevalence mets higher female patients psa male patients significantly increased prevalence hypertriglyceridemia determined patients psa significant difference existed two groups respect year cvd chd risks additionally significant differences clinical subtypes psa regard mets conclusion mets prevalence increased patients psa compared whereas risks similar cvds chd reason optimal protection measures taken guidelines applied achieve adequate metabolic control patients psa
harvested rainwater systems composting toilets expected important part sustainable solutions buildings yet date model evaluating economic environmental impact missing address need life cycle based model eeast developed eeast designed compare business usual bau case using potable water toilet flushing irrigation alternative scenarios rainwater harvesting composting toilet based technologies eeast building characteristics occupancy precipitation used size harvested rainwater composting toilet systems life cycle costing life cycle assessment methods used estimate cost energy greenhouse gas ghg emission payback periods pps five alternative scenarios scenarios modeled include use harvested rainwater toilet flushing irrigation use composting toilets without harvested rainwater use irrigation sample simulation using eeast showed office building modeled cost pps greater energy pps turn greater ghg emission pps primarily due energy emission intensive nature centralized water wastewater infrastructure sample simulation also suggested composting toilets may best performance criteria however eeast explicitly model solids management may give composting toilets unfair advantage compared flush based toilets eeast results found sensitive cost values used model availability eeast life cycle cost energy ghg emissions performed fairly easily building designers researchers future work recommended improve eeast evaluate different types buildings climates better understand composting toilets harvested rainwater systems outperform bau case building design elsevier ltd rights reserved
increasing demand ultra low latency services cellular networks fog edge computing one promising solutions migrate computing cloud edge network rather relying distant cloud additional servers propose fog radio access network ran leverages current infrastructures radio access network small cells macro base stations pursue ultra low latency joint powerful computing multiple ran nodes near range communications edge optimization problem firstly formulated tackle tradeoff communication computing resources time domain within distributed computing scenario propose cooperative task computing operation algorithm simultaneously decide many ran nodes selected proper communication resource allocation computing task assignment numerical results show ultra low latency services achieved ran via cooperative task computing
integrated optical signal processors many applications photonic processing microwave signals provides wideband stable signal processing operations miniaturized chips ultimate control precision creating general purpose processors introducing programmability key enable system function flexibility therewith offer great potential wide range applications review recent progress area highlights number key programmable chips promising applications
innovative systems automated computational procedures based computer vision inertial wearable sensors recently adopted provide effective accurate monitoring analysis cow behaviour respond different issues related cow health welfare study new open source algorithm characterised linear computational time defined implemented aim improve real time monitoring analysis walking behaviour dairy cows applied novel inertial sensor based system composed low cost devices including wearable sensors open source software operating sampling frequency algorithm computed number steps cow accelerometer data making use statistically defined thresholds two vector variables considered study accelerometer signals signal vector magnitude signal magnitude area algorithm accuracy carried comparing total error relative measurement error rme sensitivity analysis parameters computed thresholds carried analyse variation error made algorithm results showed algorithm produced equal rme sensitivity analysis confirmed proposed thresholds provided minimum errors rme less suitable measuring accuracy step counter fact underestimated overestimated numbers steps counted algorithm tended compensate rme computation iagre published elsevier ltd rights reserved
background vestibular rehabilitation effective treatment dizziness due vestibular dysfunction given biological relationship vestibular symptoms headache headache patients vestibular migraine could improved vestibular rehabilitation leads improvement dizziness study aimed compare effects vestibular rehabilitation headache outcomes relating dizziness psychological factors patients patients patients dizziness tension type headache patients without headache methods participants included patients dizziness comprising patients patients tension type headache patients without headache participants hospitalized days taught conduct vestibular rehabilitation program assessed using dizziness handicap inventory dhi headache impact test hit hospital anxiety depression scale hads somatosensory catastrophizing scale sscs underwent center gravity fluctuation measurement objective dizziness severity index month months hospitalization results tension type headache groups demonstrated significant improvement hit score improvement dhi hads sscs part objective dizziness index also shown patients without headache following vestibular rehabilitation change hit rehabilitation group positively correlated changes dhi anxiety hads changes hit tension type headache group positively correlated changes anxiety sscs conclusion vestibular rehabilitation contributed improvement headache patients patients dizziness tension type headache addition improvement dizziness psychological factors improvement dizziness following vestibular rehabilitation could associated improvement headache prominently compared comorbid tension type headache
batteries power tank solar power systems play role power supply sun shine paper provides review battery charging control techniques photovoltaic systems addition presents new battery charge controller keeps good features resolves drawbacks limitations traditional controllers new controller based newly developed maximum power point tracking mppt technique enabling fast maximum power point mpp capture moreover utilizes constant current constant voltage cccv charging scheme reduce battery charging time addition enables accessing system parameters remotely monitoring administration purposes order determine performance parameters proposed controller prototype implemented together microcontroller based converter experimental results show new controller tracks mpp faster conventional controllers moreover charging period significantly reduced moreover proposed controller high accuracy minimizes steady state oscillation errors around target mpp elsevier ltd rights reserved
immune system possesses vast number potential targets therapeutic intervention although therapies many pathways pursued yielded significant success hindrances altering biologic pathways include potential unwanted downstream effects ineffectiveness owing biological redundancy recognition therapeutic molecule foreign body innate immune system risks subsequent malignancy autoimmunity article covers currently available biotherapeutic agent classes well potential direction future therapy
concatenated greenberger horne zeilinger ghz state new type multipartite entangled state potential application future quantum information paper propose protocol constructing arbitrary ghz entangled state approximatively different previous protocols logic qubit encoded coherent state protocol based linear optics feasible experimental technology protocol may useful quantum information based ghz state
fractional calculus three hundred year old concept way back time hospital leibniz focusing derivative integrals non integer orders almost four decades ago engineers scientists began venture field fractional calculus unfolding applications fractional differential equation models valid found fractional calculus indeed becoming ubiquitous seeing applications many fields sciences engineering fractional diffusion equations various biomedical applications signal processing control engineering applications conclusion later proposed fractional calculus actually generalization integer order calculus powerful could overcome advantages integer order counterparts paper offers comprehensive discussion applications fractional calculus design implementation fractional order systems form electronic circuits could used signal processing control engineering applications article starts introduction fractional calculus including history mathematical definitions second part article focuses fractional order differential equations systems example circuit designs implementation discussed includes elaboration papers related area final part article presents possible research topics area
work focused estimation power requirements electric vehicle platform evp intra campus transport using high fidelity computational fluid dynamics cfd model based incompressible navier stokes equations starting point ordinary auto rickshaw battery powered electric motor replaces engine work aims benchmark aerodynamic drag evp standard auto rickshaw designing chassis assess power requirements evp
objective appropriate timely complementary feeding practices fundamental child growth health development first years life study aimed understand ghanaian mother complementary feeding practices perceived observed impacts complementary feeding children methods ghanaian mothers children months age recruited four communities komenda edina eguafo abrem district central region ghana qualitative methodological approach focus group interview discussions used eleven focus group interviews conducted audio recorded transcribed audio transcriptions coded analyzed pertinent themes meta themes theoretical concepts results mothers reported poor knowledge effects complementary feeding children children undernourished indicating inappropriate complementary feeding practices mothers held misconceptions effect food children health four overarching themes identified mothers background knowledge food child health growth outcomes mothers motivation feeding children barriers feeding foods mothers offered children conclusion practice nutrition education complementary feeding needed ghanaian mothers health facilities community outreach programs could venue provide education mothers regarding infant young child feeding practices ghana
human chondrocytes accumulate ecm rich matrix secreting matrix macromolecules monolayer culture makes difficult transfect efficiently report non viral based protocol transfect primary human chondrocytes high efficiency suspension chondrocyte cultures digested using pronase collagenase transfected suspension transfection efficiencies achieved routinely using protocol described viability sirna transfected transfected chondrocytes affected resulted knockdown target mrna levels protocol may useful gene knockdown ectopic overexpression studies chondrocytes elsevier inc rights reserved
paper explores lgbtiq students experiences knowing performing holding queerness tertiary educational environment interviews conducted lgbtiq students large australian metropolitan university examine students engagement lgbtiq students tertiary educational space although originally intending explore lgbtiq students experience violence harassment abuse campus study identified number themes concerning normalisation set beliefs practices presentations performances drawing frameworks hetero homo trans normativity explore lgbtiq students articulated concerns knowing performing holding authentic queerness find lgbtiq students experienced barred access knowledge hostility dismissal lgbtiq students either perceived queer queer enough behind interactions heart tensions notion authentic queer identity post gay era continuous challenges lgbtiq students face within heteronormative society new insights lgbtiq students negotiate manage shape interactions higher educational settings provided implications tertiary educational institutions particular need support diverse lgbtiq community discussed
chronic rejection organ transplantation defined humoral cell mediated immune response directed allograft lung transplantation chronic rejection nowadays clinically defined cause chronic lung allograft dysfunction clad consisting different clinical phenotypes including restrictive allograft syndrome ras bronchiolitis obliterans syndrome bos however differential role humoral cellular immunity investigated explant lungs patients end stage bos ras assessed presence lymphoid cells myeloid cells dendritic cells eosinophils mast cells neutrophils macrophages compared nontransplant control lung biopsies myeloid cells exception dendritic cells increased ras versus control neutrophils eosinophils mast cells macrophages regarding lymphoid cells cells cytotoxic cells increased remarkably ras versus control bos versus control interestingly lymphoid follicles restricted ras versus control versus bos data suggest immunological diversity bos ras pronounced involvement cell response ras characterized structural organization lymphoid follicles may impact future therapeutic approaches
division one important basic arithmetic operations especially areas computer graphics digital signal processing however also difficult implement hardware several architectures algorithms researched either implementation high complexity sacrifice speed precision work decimal fixed point division great simplicity structure high degree speed precision presented architecture based successive approximation register results validated experimentally motor control drive proposed implementation useful future researchers seeking fast precise division methodology low complexity hardware structure
mycotoxins secondary metabolites fungal species frequently occurring natural food contaminants human animal diets risk assessment mycotoxins focused yet mutagenic genotoxic potential carcinogenic effects recently increasing awareness adverse effects various mycotoxins vulnerable structures intestines particular impairment barrier function epithelial lining cells sealing tight junction proteins noted could result increased translocation luminal antigens pathogens excessive activation immune system current review aims provide summary available evidence regarding direct effects various mycotoxins intestinal epithelial barrier available data based different cellular animal studies show food associated exposure certain mycotoxins especially trichothecenes patulin affects intestinal barrier integrity result increased translocation harmful stressors therefore hypothesized human exposure certain mycotoxins particularly deoxynivalenol major trichothecene may play important role etiology various chronic intestinal inflammatory diseases inflammatory bowel disease prevalence food allergies particularly children
introduction food addiction recent term used describe craving food addition functional impairment thoroughly studied adolescents aim study assess presence egyptian adolescents relations psychiatric correlates anxiety depression subjects methods across sectional design used four hundred adolescents interviewed different geographic locations cairo assess yale food addiction scale yfas depression child depression inventory cdi scale anxiety screen child anxiety related disorders scared child version questionnaire results present studied adolescents depression present adolescents depression coexisted subjects diagnosis anxiety met adolescents coexisted food addiction one adolescent scores showed moderately significant positive correlations anxiety subtypes well total score anxiety depression symptomatology significantly different without anxiety depression conclusion exists egyptian adolescents strong associations psychiatric comorbidities anxiety depression evaluated every individual vice versa psychiatric morbidities may inciting factor development food addiction evaluation treatment address existent comorbidities careful attention paid presence excess food consumption despite knowledge adverse consequences tolerance withdrawal symptoms important social occupational activities given reduced presence coincided study presence depression anxiety makes psychiatric evaluation valuable egyptian pediatric association production hosting elsevier open access article license http creativecommons org licenses
recent research theorizing suggest desires group based dominance underpin biases towards human outgroups non human animals systematic study common ideological roots human human human animal biases however lacking three studies belgium usa tested social dominance human animal relations model harm proposing social dominance orientation sdo key factor responsible significant positive association ethnic outgroup attitudes speciesist attitudes towards animals even accounting ideological variables possibly confound previous findings confirming hypotheses results consistently demonstrated sdo right wing authoritarianism rwa key factor connecting ethnic prejudice speciesist attitudes furthermore studies showed sdo rwa significantly related perceived threat posed vegetarianism ideologies diets minimizing harm animals sdo playing focal role explaining positive association threat perceptions ethnic prejudice study replicated pattern additionally including political conservatism model significant correlate speciesism finally meta analytic integration across studies provided robust support harm offers important insights psychological parallels human intergroup human animal relations copyright european association personality psychology
purpose reviewthe purpose review summarize recent evidence management preschool children wheezing asthma propose phenotype based approach management children recent findingsrecent studies begun identify populations preschool children likely benefit inhaled corticosteroids ics therapy defined ics regimens daily ics preschool children persistent asthma pre emptive high dose intermittent ics among preschool children intermittent disease reduce risk exacerbation addition among preschool children mild persistent asthma presence aeroallergen sensitivity blood eosinophil counts greater predictors good response daily ics therapy studies identified intermittent azithromycin therapy prevent potentially treat acute exacerbations uncertainty role oral corticosteroids ocs therapy acute exacerbations continues recent meta analysis showed ocs prevent hospitalizations urgent visits reduce need additional courses ocs whereas previous epidemiologic studies suggested acetaminophen may increase risk exacerbations clinical trial clearly demonstrated acetaminophen use compared ibuprofen use increase exacerbation risk among preschool children mild persistent asthma summaryrecent studies shown potential phenotypic driven therapies management preschool children asthma targeting airway bacteria emerged promising therapeutic approach effect antibiotic resistance still needs investigated finally studies required evaluate oral corticosteroids provide benefits acute episodic wheeze
class multivariate levy driven autoregressive moving average mcarma processes continuous time analogs classical vector arma processes shown equivalent class continuous time state space models linear innovations weak arma process arising sampling mcarma process equidistant grid proved exponentially completely regular mixing mild continuity assumption driving levy process verified continuity assumption satisfied practically relevant situations including case driving levy process non singular gaussian component compound poisson absolutely continuous jump size distribution infinite levy measure admitting density around zero
objectivespreexisting cognitive impairment predictor cognitive decline ischemic stroke evidence intracerebral hemorrhage ich limited aimed determine prevalence premorbid cognitive impairment patients ich materials methodswe included patients acute ich pre ich cognitive impairment determined based results informant questionnaire cognitive decline elderly iqcode uses information close relatives patients assessed cognitively impaired iqcode score iqcode indicated pre ich dementia mri images reviewed determine extent white matter lesions measure radial width temporal horn marker brain atrophy investigated differences cardiovascular risk factors imaging data patients without pre ich cognitive impairment using correlation analyses uni multivariable regression models functional neurological state assessed using modified rankin scale mrs mrs dichotomized level premorbid mrs considered functional independency resultsamong participants median age years interquartile range male iqcode indicated pre ich cognitive impairment functionally independent ich cognitive impairment associated premorbid mrs chi squared test multivariable analysis prior stroke transient ischemic attack hematoma volume independently associated pre ich cognitive impairment conclusionsin conclusion cognitive impairment frequently precedes ich higher frequency cerebrovascular events suggests role vascular processes development cognitive impairment ich
objective respiratory illness posttraumatic stress disorder ptsd common debilitating conditions frequently occur observational studies indicate ptsd independently smoking major risk maintenance factor lower respiratory symptoms lrs current study experimentally tested etiologic pathway investigating whether lrs reduced treating ptsd symptoms method ninety daily smokers exposed world trade center wtc disaster mean age years female white completed session group based weekly comprehensive trauma management smoking cessation treatment focused skills alleviate ptsd symptoms lrs ptsd symptoms smoking assessed weekly data analyzed using multilevel models within person associations lrs ptsd symptoms smoking treatment dose across weekly sessions concurrent lagged outcomes results lrs improved significantly treatment reduction standard deviations reduction ptsd symptoms uniquely predicted improvement lrs consecutive sessions week apart fully accounted treatment effect lrs effect ptsd symptoms stronger smoking effect remain significant entered model notably reduction lrs predict future improvement ptsd symptoms conclusions results line etiologic pathway suggesting ptsd symptoms risk maintenance factor chronic lrs treatment ptsd help alleviate lrs trauma exposed populations ptsd emerging novel important treatment target chronic respiratory problems
article describes test hypothesis people self concept overly focused financial success focus contributes disordered gambling study reported development validation financially focused scale ffs sample community gamblers predicted participants whose self concept financially focused attached greater importance money possess domain self worth also indicated money possess important domain self worth relative life domains importantly greater financial focus positive predictor disordered gambling severity known predictors disordered gambling severity personal income big five personality domains global self esteem personal relative deprivation materialism study replicated extended findings study examining motivational mechanisms may link financially focused disordered gambling severity hypothesized monetary gambling motives mediated relationship participants ffs scores disordered gambling severity financially focused self concept may play critical role development maintenance disordered gambling addressing self concept treatment may help alleviate gambling disorder
study new versatile active element namely multifunction current differencing cascaded transconductance amplifier mcdcta proposed proposed mcdcta enjoys advantages low voltage low input high output impedance wide bandwidth etc simplifies design current mode analog signal processing circuit greatly especially design high order filter oscillator circuits moreover example new current mode multiphase sinusoidal oscillator mso using proposed mcdcta described paper proposed mso consists one mcdcta minimum grounded passive elements could provide parts per thousand output current signals equally phase difference output current signals high output impedance terminals oscillation condition oscillation frequency mso could linearly electronically adjusted controlling bias currents mcdcta suitable variable frequency oscillator application operation proposed oscillator verified pspice simulation experimental results
interactive evolutionary computation iec solution evaluated human users means small number solutions evaluated execution iec algorithm application fields iec hearing aid design music composition single solution evaluated time moreover accurate precise fitness evaluation easy human users based discussions formulated iec model minimum requirements human users fitness evaluation ability evaluate single solution time memorize single previous solution evaluation result current solution whether better previous solution paper propose meta level approach design interactive algorithms iec model novelty approach use different operator generate solution iec algorithm coded string operators generate solutions random creation mutation crossover string length number solutions generated string iec algorithm evaluated simulations iec model population strings evolved meta level evolutionary algorithm perform experimental studies using well known test function surrogate human user simple test function obtain style algorithms next solution generated mutation best solution among examined ones complicated test function obtain style algorithms crossover mutation random creation
analytical model silicon insulator soi tunnel field effect transistor fet linearly graded workfunction modulated gate proposed improve device performance subthreshold slope optimization surface potential suggested model analyzed using two dimensional poisson equation imposed channel boundary conditions electrical parameters electric field drain current transconductance evaluated examine performance model moreover performance terms values proposed model downscaling gate oxide thickness silicon body thickness also investigated results compared results conventional tunnel fet tfet model present model exhibits significant reduction subthreshold slope improvement performance accuracy model verified technology computer aided design tcad model simulations
objective examine mediating role maladaptive schemas permissive authoritarian parenting fathers personality disorders including histrionic antisocial narcissistic depressive attitudes among adults methods cross sectional study conducted university sargodha sargodha pakistan comprised university students data collected administering parental authority questionnaire young schema questionnaire personality diagnostic questionnaire spss used data analysis study completed one year started june ended june results participants handed questionnaires returned fully filled women men scales greater alpha reliability coefficients values skewness scales ranged permissive parenting style positive correlation histrionic narcissistic antisocial personality disorders authoritarian parenting positive correlation early maladaptive schemas depressive personality disorder conclusion permissive authoritarian parenting styles led personality disorders among offspring adult phase lives
shape memory alloy sma expected applied intelligent smart material since shows functional characteristics shape memory effect superelasticity sma elements characteristics perform cyclic motions cases fatigue property sma one important issues view evaluating functional characteristics sma elements fatigue proper ties complex since depend stress strain temperature hysteresis sma implanted high energy ions thermomechanical properties material may change resulting long fatigue life present study nitrogen ion implantation applied modify surface tini sma tape influence implantation treatment bending fatigue properties investigated
discrepancies physicians assessment patients subjective representations disease severity may influence physician patient communication management chronic illness multiple sclerosis reasons important recognize factors distinguish patients differently estimate impact purpose study verify patients overestimate underestimate impact differ perception personal resources individuals presenting realistic appraisal physical condition total women men diagnosed completed multiple sclerosis impact scale university washington self efficacy scale rosenberg self esteem scale body esteem scale brief illness perception questionnaire treatment beliefs scale actually received support scale socioeconomic resources scale physician assessment health status determined expanded disability status scale linear regression analysis conducted identify subsets patients various patterns subjective health expanded disability status scale edss scores patients overestimating impact disease presented significantly lower levels self esteem self efficacy body esteem furthermore perceived condition threatening realists underestimators also assessed anti treatment worse less socioeconomic resources received less support underestimators additionally underestimators presented significantly better perception disease self body realists self assessment related symptoms associated specific perception personal resources coping disease findings may facilitate communication patients point new directions future research adaptation
flow around array vertical solid surface mounted cylinders characterized cylinders model support structures used marine hydrokinetic mhk device mhk devices extract kinetic energy flowing water use turn electrical generator array configuration thought contribute performance amount extractable power example offset array might extract energy side side array offset array could extract energy flow wakes upstream structures funnel incident flow increasing kinetic energy flux onto downstream turbine testing array cylinders conducted long wide deep open channel flume located environmental fluid mechanics hydraulics laboratory efm bucknell university velocity flow field measured using acoustic doppler velocimeter adv upstream downstream single cylinder evaluate wake properties wake properties applied varying array cylinders power estimates flow field made front downstream cylinder discovered cylinders move farther six diameters upstream available power remains constant additionally optimal spacing cylinders somewhere less four diameters upstream
bafa lake one largest turkish lagoon lakes aegean region covering surface area water capacity myriad benefits aquaculture facility agricultural activities tourism lake considered important wetland within buyuk menderes basin study investigate aquaculture facilities anthropogenic sources pollutions affect water quality bafa lake major factors control quality bafa lake water agricultural activities basin domestic industrial wastes come buyuk menderes river surrounding lake fisheries aquaculture facilities contaminants located lake continuously negative impact water quality last three decades effect sea bream sparus aurata sea bass dicentrarchus labrax cultivation facilities surface water quality lake determined water samples taken five stations april march bafa lake sample analyzed water temperature dissolved oxygen electrical conductivity amonium nitrogen nitrite nitrogen nitrate nitrogen orthophosphate result surface water quality assessed based comparison samples collected near aquaculture stations reference sample taken outside cultivation area compared water pollution registration act wpra standards according wpra surface water quality lake classified level end analyses revealed area aquaculture activities intense showed high rate polution stations well reference station results show aquaculture activities sea bream sea bass negative impact entire bafa lake
risk factors non skin cancer novo malignancy dnm lung transplantation yet identified queried united network organ sharing database adult lung transplant patients standardized incidence ratios sirs computed comparing data surveillance epidemiology end results program data excluding skin squamous basal cell carcinomas identified adult lung transplant patients median follow time days interquartile range dnms occurred patients incidences years respectively overall cancer incidence elevated compared general population sir confidence interval common cancer types lung cancer malignancies sir lymphoproliferative disease sir predictors dnm following lung transplantation age hazard ratio male gender disease etiology cystic fibrosis idiopathic pulmonary fibrosis interstitial lung disease single lung transplantation significant interactions donor recipient smoking single lung transplantation noted multivariable survival analysis dnms associated increased risk mortality authors find novo malignancies occur often lung transplant recipients compared general adult population associated increased hazard mortality multivariable analysis
silicon photonics compatible mature complementary metal oxide semiconductor cmos fabrication process extensively demonstrated monolithic integration photonic electrical circuits show integrated silicon mach zehnder modulator mzm may used advanced modulation formats despite nonlinear dependence refractive index change applied voltage free carrier depletion modulator experimentally demonstrated use silicon mzm direct detection optical orthogonal frequency division multiplexing ddo ofdm modulation advanced data formats quadrature phase shift keying qpsk phase shift keying psk quadrature amplitude modulation qam measured bit error rate performance back back single mode fiber transmission format well forward error correction limit
recently hashing multiple tables become attractive many real life applications owing theoretical guarantee practical success pursue desired performance usually great efforts required hashing algorithm design specified scenario hash bit selection serves general method provide satisfying performance different scenarios utilizing existing hashing algorithms paper novel bit selection framework via walks graph proposed support compact hash code generation complementary hash table construction formulates selection problem subgraphs discovery edge vertex weighted graph desired subset corresponds frequently visited ones bits tables markov process framework unified compatible different hashing algorithms compact code generation selects independent informative hash bits using markov process candidate bit graph complementary hash table construction exploits hierarchical authority relations among candidate bits separates number bit subsets candidate tables multiple complementary hash tables efficiently selected experiments conducted two important selection scenarios hashing using different hashing algorithms hashing multiple features results indicate proposed selection framework achieves significant performance gains naive selection methods different scenarios elsevier rights reserved
keeping special issue theme remembering future article provides selective review research memory social information social category representation influences future processing behavior specifically authors focus categorization stereotyping affect perceive others first part article reviews research individuals perceive others authors review research determinants outcomes social categorization stereotype activation concluding influence ingroup outgroup categorization face processing second part article reviews research individuals perceive authors argue stereotype threat concerns judged behaving ways confirm negative group stereotypes leading poor performance result self categorization stereotype activation overall article highlights complex relationship memory social category information future social perception behavior elsevier inc rights reserved
estimating positions set moving objects captured network cameras still open problem computer vision paper distributed real time approach tracking multiple objects multiple cameras presented quantitative comparison six state art methods carried publicly available pets data set demonstrating effectiveness algorithm moreover proposed method tested also multi camera soccer data set showing data fusion capabilities
paper discussed electrical network power quality improvement distributed generation optimum placement objective placement power losses reduction optimization conducted breeder genetic algorithm bga method simulation result showing bga method generated power losses reduction
decision selecting appropriate procurement delivery system large investment construction projects critical challenging task clients therefore significant factor project success complex projects electric power plants involve managing multiple contracts subcontracts simultaneously sequence aim paper develop analyze decision support tool select efficient procurement delivery system multiple contracts combined cycle power plants ccpp constructed egypt funded publicsector process involved identification various procurement routes followed utilization quantitative values developed accordance requirements multi criteria decision analysis technique known simple multi attribute rating technique smart results revealed procurement delivery system highest score contractual packages integrated project delivery method ipd procurement delivery methods could utilized performance based contracting pbc construction management research sensitivity analysis approach adopted validate ipd selection determine critical criterion critical measure performance contractual package
objectives reliable predictors response lithium still lacking bipolar disorders bds however childhood trauma hypothesized associated poor response lithium methods included patients euthymic retrospectively clinically assessed response lithium childhood trauma using reliable scales results according alda scale sample consisted excellent responders partial responders nonresponders lithium higher level physical abuse significantly correlated lower level response lithium compared patients exposed abuse patients least two trauma abuses emotional physical sexual risk belonging non responders group among investigated clinical variables lifetime presence mixed episodes alcohol misuse associated non response lithium multivariate analyses demonstrated physical abuse mixed episodes independently associated poor response lithium respectively conclusions childhood physical abuse might involved poor future response lithium prophylaxis effect independent association clinical expression poor response lithium
paper presents virtual laboratory ball plate system two dimensional extension well known ball beam problem ball plate non linear multi variable open loop unstable system due inherent complexity presents challenging problems point stabilization control carry ball specific position hold trajectory tracking control goal make ball follows predefined trajectory linear square circle lissajous curve minimizing tracking error time virtual laboratory developed easy java simulations ejs provides interactive simulation system allows study two aforementioned problems laboratory used systems control engineering master program offered national university distance education complutense university ifac international federation automatic control hosting elsevier ltd rights reserved
paper focuses examines issues problems related remote evaluation software engineering competences using progressive competence representation model authors suggested original approach master program software engineering competence evaluation combination academic competences professional competences european competence model examples competence description subjects proposed joint master program software engineering developed several types scoring rubrics software engineering competences evaluation reviewed rubrics templates created developed models templates used universities enterprises training results evaluation well competence evaluation software engineering master program graduates authors published elsevier
increasing installed capacity wind power interdependencies among multiple energy sectors optimal operation integrated energy systems ies combined cooling heating power cchp becoming important paper proposes optimal dispatch strategy ies cchp wind power natural gas system modeled security constraints integrated optimal dispatch model gas shift factor gsf gas matrix natural gas system derived quantify impact gas supply load node gas flow pipelines pipeline flow equation linearized objective function optimization model minimize total operation cost ies model transformed mixed integer linear programming milp formulation improve computation efficiency numerical case studies conducted demonstrate lower operation cost proposed model facilitating wind power integration elsevier ltd rights reserved
proportion workers larger ever current work force trends indicate global increases retirement ages many individuals working later ages decades past older people applying jobs later ages research date age discrimination selection focused primarily disparate treatment intentional discrimination however based accumulated knowledge age related changes cognitive physical abilities well changes personality work motivation across life course suggest attention paid possibility age based subgroup differences selection procedures manifested adverse impact differential prediction provide recommendations guide future human resource management research practice elsevier inc rights reserved
objective exploring pathophysiological changes transient receptor potential vanilloid trpv receptor trigeminovascular system high fat high sucrose hfhs diet induced obesity experimental animals background clinical experimental observations suggest link obesity migraine accumulating evidence indicates metabolic immunological alterations associated obesity may potentially modulate trigeminovascular functions possible target obesity induced pathophysiological changes trpv capsaicin receptor implicated pathomechanism headaches complex way methods male sprague dawley rats fed regular hfhs diet weeks end dietary period body weight animals normally distributed groups significantly higher animals hfhs diet therefore experimental groups regarded control hfhs diet induced obese groups capsaicin induced changes meningeal blood flow release calcitonin gene related peptide cgrp dural trigeminal afferents measured control obese rats distribution trpv cgrp immunoreactive meningeal sensory nerves also compared whole mount preparations dura mater metabolic parameters animals assessed examining glucose insulin homeostasis well plasma cytokine concentrations results hfhs diet accompanied reduced food consumption greater fluid energy intakes addition increased body weight animals hfhs diet increased fasting blood glucose insulin concentrations well levels circulating proinflammatory cytokines interleukin beta interleukin obese animals dural application archetypal trpv agonist capsaicin resulted significantly augmented vasodilatory vasoconstrictor responses compared controls diet induced obesity also associated enhanced basal capsaicin induced cgrp release meningeal afferents vivo except minor morphological changes distribution dural trpv cgrp immunoreactive afferents similar control obese animals conclusions results suggest obesity induced long term hfhs diet results sensitization trigeminovascular system changes trpv mediated vascular reactions cgrp release pathophysiological alterations may relevance enhanced headache susceptibility obese individuals
ambient intelligence ami deals new world ubiquitous computing devices physical environments interact intelligently unobtrusively people ami environments diverse homes offices meeting rooms schools hospitals control centers vehicles tourist attractions stores sports facilities music devices paper present design implementation testbed ami using raspberry mounted raspbian analyze performance optimized link state routing olsr wired equivalent privacy wep protocol indoor scenario evaluation considered throughput delay jitter metrics experimental results show nodes testbed communicating smoothly
dimensional higher order broer kaup hbk system investigated paper painleve test shows two solution branches one resonance auto backlund transformation obtained truncated painleve expansion new analytic solutions presented means auto backlund transformation including periodic soliton like solutions similarity reductions hbk system given two ordinary differential equations odes direct method
presented herein fundamental study laser ignition methane air mixtures temperatures pressures representative internal combustion engine yag laser operating lambda used ignite methane air mixtures equivalence ratios phi rapid compression machine rcm experiments conducted study lean limit minimum spark energy mse minimum ignition energy mie results show laser ignition exhibits stochastic behavior must interpreted statistically probability occurrence used evaluate mse mie resulted mse mie equivalence ratio phi compressed pressure temperature comp bar comp respectively lean limit characterized based fraction chemical energy converted thermal energy determined calculating apparent rate heat release derived rcm high speed pressure data lean limit chemical energy conversion found correspond equivalence ratio comp schlieren photography employed diagnostics tool visualize flame initiation propagation inside rcm combustion institute published elsevier inc
epidemiological animal studies suggested association habitual sleep patterns cardiovascular disease results still controversial therefore aims study investigate relationships habitual sleep patterns disease based prospective urban rural epidemiology pure china study pure china study recruited participants aged provinces communities china habitual sleep patterns disease self reported multilevel logistic regression used analysis study participants eligible analysis including women men sleeping per day associated increased odds disease compared sleeping per day taking daytime naps also associated increased odds disease odds increased increasing napping duration trend sleeping per day found association coronary artery disease cad participants sleep per night lowest prevalence disease compared sleep patterns napping long short duration habitual sleep may increase odds disease participants sleeping hours night recommended study large longitudinal studies needed confirm results
objective study examined key functional outcomes following week interdisciplinary pediatric pain rehabilitation program adolescents chronic pain maintenance gains evaluated month follow methods participants included adolescents age chronic pain completed hospital based outpatient pediatric pain rehabilitation program participants completed measures functional disability depressive symptoms pain catastrophizing opioid use school attendance pain severity admission discharge month follow results similar interdisciplinary pediatric pain rehabilitation program outcome studies significant improvements observed end program improvements appeared maintained improved month follow nearly patients taking daily opioid medication admission program adolescents completely tapered medications end week program remained abstinent month follow discussion study adds available data supporting interdisciplinary pediatric pain rehabilitation effective improving functioning psychological distress even discontinuing opioids implications future research limitations study discussed
viral myocarditis common cardiovascular disease seriously endangers health people even leads sudden unexpected death micrornas play important roles various physical pathological processes including cardiogenesis heart diseases recent years mir implicated various diseases breast cancer gastric cancer hepatocellular carcinoma cardiovascular diseases however function mir pathological progress viral myocarditis reported study found mir regulated mouse heart tissues post coxsackievirus cvb infection bioinformatics analysis identified zfp transcription factor plays essential roles regulation virus replication one predicted targets mir mir expression found regulated zfp protein level markedly repressed viral myocarditis studies demonstrated mir directly binds utr zfp suppresses translation moreover aberrant expression mir promoted expression anti apoptosis proteins bcl bcl suggesting altered gene expression might promote cardiomyocytes survival viral myocarditis findings indicated mir might potential therapeutic target cvb induced viral myocarditis useful marker diagnosis viral myocarditis
paper proposes novel idea synthesis active filters based use signal flow graph sfg stamps differential difference current conveyors ddccs basis rlc passive network filter symbolic transfer function equivalent sfg constructed ddccs sfgs identified inside constructed active graph thus equivalent circuit easily synthesized show ddcc derivatives differential voltage current conveyors conventional current conveyors main basic building blocks design practicability proposed technique showcased via three application examples spice simulations given show viability proposed technique
construction worker work day spent construction site means large part worker health wellbeing could depend construction site environs construction work inherently stressful due ever present threat fatalities injuries compromises ergonomic reality human sustenance construction sites necessitates need create beneficial comfortable environment motivational inspirational healing biophilic construction site model bcsm involves methodology greening construction sites proposed healthy means tapping natural resources construction site environment intended create comfort zone construction site would generate symbiotic benefit enhance humanistic value engender health wellbeing creative performance workers paper reports case study form focus group study comparative analysis two similar construction sites northern cape region south africa findings present healthy inter nurture existing living construction site human occupants cost effective psychotherapeutic intervention sustainable sites initiative ergonomics according research findings yet missing construction management body knowledge cmbok paper conclusively recommends greening construction sites specifically inclusion plants within site offices welfare facilities worksite premises relevant means harnessing nature healing rejuvenating essence towards productive goal construction american society civil engineers
natural mechanical strength materials highly dependent crystal structure four different silicate derived ceramics diopside akermanite monticellite merwinite synthesized evaluated potential bone augments grafts sparks interest fabrication polycaprolactone pcl ceramic composites potential use scaffolds diopside possesses three dimensional structure among four shows highest mechanical strength stable structure physiological solution added polycaprolactone high concentration turn incorporation merwinite composite scaffolds led materials poor mechanical strength unstable physiological environments ceramic concentration reaches cyto compatibility osteogenic studies four ceramics revealed ceramic cytocompatible supports human adipose derived stem cells hascs proliferation stromal medium akermanite monticellite exhibit better osteogenic properties diopside merwinite suggesting might optimal material fabricating bone scaffolds
allergy host immune response towards harmless substances called allergens allergic diseases comprise allergic asthma allergic rhinitis allergic conjunctivitis atopic dermatitis food allergy drugs counteract symptoms inflammation arising allergy completely effective acceptable side effect free drug developed yet moreover severe asthma atopic dermatitis classified unmet clinical needs mast cells eosinophils main effector cells allergic response thus must first cells targeted impede allergic inflammation symptoms evolution presence mast cells eosinophils several surface receptors either activating inhibitory functions indicates possibility pharmacological targeting review deals receptors expressed mast cells eosinophils ligand receptors already exploited drug targets others feasibly utilized novel targets anti allergic therapy elsevier inc rights reserved
lorentz force classical electrodynamics applied magnetic materials gives rise hidden energy hidden momentum removing contributions hidden entities poynting vector electromagnetic momentum density lorentz force torque densities simplifies equations classical theory particular reduced expression force density becomes similar identical einstein laub expression force exerted electric magnetic fields distribution charge current polarization magnetization examples reveal similarities differences among various equations describe force torque exerted fields material media important example simplifications afforded einstein laub formula provided magnetic dipole moving static electric field exhibiting aharonov casher effect
dermatitis artefacta lies gray zone specialities psychiatry dermatology condition could mimic number lesions therefore source much confusion clinical practice describe case dermatitis artefacta years old girl resembled self harming behavior borderline personality disorder discuss two could differentiated becomes imperative dealing cases
paper devoted investigation existence compact random attractor random dynamical system generated coupled suspension bridge equations white noises elsevier inc rights reserved
voltage mode high input impedance first order allpass highpass lowpass filters using one differential voltage current conveyor dvcc one grounded capacitor two resistors presented allpass highpass lowpass signals obtained simultaneously circuit configuration simulation results confirm theoretical analysis
background persons inject drugs pwid might increased risk mycobacterium tuberculosis infection reactivation latent tuberculous infection ltbi due injection drug use objectives determine prevalence correlates tuberculosis infection among pwid san diego california usa methods pwid aged years underwent standardized interviews serologic testing using interferon gamma release assay igra ltbi rapid point care assays human immunodeficiency virus hiv hepatitis virus hcv infections independent correlates tuberculosis infection identified using multivariable log binomial regression results total participants met eligibility criteria mean age years standard deviation subjects white orhispanic male overall reported ever traveled mexico prevalence tuberculosis infection infected hiv infected hcv almost participants previously tested tuberculosis previously told infected tuberculosis infection independently associated hispanic longer injection histories testing hcv positive correctly reporting people sleeping infect others conclusions strategies needed increase awareness treatment tuberculosis infection among pwid mexico border region
dynamic behaviour slider crank mechanism associated smart flexible connecting rod investigated effect various mechanisms parameters including crank length flexibility connecting rod slider mass dynamic behaviour studied two control schemes proposed elastodynamic vibration suppression flexible connecting rod also obtaining constant angular velocity crank first scheme based feedback linearization approach second one based sliding mode controller input signals applied electric motor located crank ground joint two layers piezoelectric film bonded top bottom surfaces connecting rod controllers successfully suppress vibrations elastic linkage society cad cam engineers publishing servies elsevier
severity criterion used dsm bulimia nervosa investigated individuals referred treatment regional eating disorders service addition comparing eating disorder symptoms impairment secondary symptoms also assessed according guidance dsm individuals classified mild moderate severe extreme levels severity due small numbers latter two groups necessary combine form one severe extreme group analyses three groups suggested group effect demographic variables differences seen measures eating pathology psychological distress psychosocial impairment mild group groups individuals moderate severe extreme groups scored comparably measures pathology impairment results broadly consistent past studies community samples although together question demarcation moderate severe groups individuals
long standing belief sign language interferes spoken language development deaf children despite chronic lack evidence supporting belief deserves discussion poor life outcomes continue seen deaf population commentary synthesizes research outcomes signing non signing children highlights fully accessible language protective factor healthy development brain changes associated language deprivation may misrepresented sign language interfering spoken language outcomes cochlear implants may lead professionals organizations advocating preventing sign language exposure implantation spreading misinformation existence one time sensitive language acquisition window means strong possibility permanent brain changes spoken language fully accessible deaf child sign language exposure delayed often standard practice empirical evidence harm sign language exposure evidence benefits growing evidence lack language access negative implications includes cognitive delays mental health difficulties lower quality life higher trauma limited health literacy claims cochlear implant spoken language approaches effective sign language inclusive approaches empirically supported cochlear implants unreliable standalone first language intervention deaf children priorities deaf child development focus healthy growth developmental domains fully accessible first language foundation sign language rather auditory deprivation speech skills
individual life span differences charitable giving important economic force yet underlying motives well understood adult life span sample assessed manifestations prosocial tendencies across different measurement domains psychological self report measures actual giving choices fmri derived neural indicators pure altruism latter expressed individuals activity neural valuation areas charities received money compared oneself received money thus reflected altruistic concern others results based structural equation modeling unit weighted aggregate scores revealed strong higher order general benevolence dimension accounted variability across measurement domains fact neural measures likely reflect pure altruistic tendencies indicates general benevolence based genuine concern others furthermore general benevolence exhibited robust increase across adult life span potentially providing explanation older adults typically contribute public good young adults
investigated relationships among parenting stress parental readiness change child externalizing behaviors sample clinically referred families additionally parenting stress investigated potential moderator relationship parental readiness change child externalizing behaviors sixty nine parents clinically referred children completed measures parenting stress readiness change child externalizing behaviors found child externalizing behaviors specifically hyperactivity impulsivity oppositionality significant positive relationship parental readiness change parenting stress child conduct disorder symptoms significantly relate parental readiness change parenting stress emerged significant moderator relationship child externalizing behaviors parental readiness change low levels parenting stress readiness change increased level child externalizing behaviors increased however high levels parenting stress parental readiness change remained high constant irrespective level child externalizing behaviors findings small pilot study significant implications clinicians researchers parents ready engage child mental health services may high levels parenting stress regardless severity child behaviors parents may benefit learning stress management strategies addition receiving intervention services children researchers examine clinical utility measuring readiness change families children behavior problems
introduction optic neuritis first manifestation autoimmune central nervous system diseases multiple sclerosis neuromyelitis optica also occur isolated monophasic relapsing disease proportion patients antibodies myelin oligodendrocyte glycoprotein mog report case recurrent mog antibodies south asian patient case report year old sri lankan female previous history episodes steroid responsive presented visual impairment right eye examination admission visual acuity noted left visual evoked potentials prolonged bilaterally neurological investigations including screening tests infections vasculitis unremarkable aqp antibodies negative mog antibodies positive responded intravenous long term steroids combined mycophenolate mofetil relapsed steroids discontinued relapse free low dose steroids mycophenolate years conclusions recurrent occurs association mog antibodies distinct neuromyelitis optica multiple sclerosis may require steroid based immunosuppression maintain remission case report south asia adds map worldwide occurrence mog antibody disease
power transformers illustrate majority capital investment transmission distribution centers additionally interruptions power transformer significant economic effects performance electrical network reason safe reliable performance relate directly security stability power system paper studies growth power losses derating distribution transformer working unbalance voltage unbalanced load conditions paper computer based simulation utilizing two three dimensional finite element methods fem exploited tool visualizing magnetic fields distribution transformers finite element method fem one among popular numerical methods able handle problem complexity various forms performance transformer load supply balanced compared case voltage load unbalanced indicates unbalanced load causes copper loss increase unbalanced voltage increases copper loss also adds core loss indices voltage unbalance factor vuf used paper evaluate unbalance propagation process enables software simulate analyze different electromagnetic parameters magnetic flux lines flux density losses etc different input sources high accuracy
study presents theoretical method find dimensions rectangular micro asperities using principles hydrodynamics strength materials suitable value width microasperities calculated critical height micro asperities also calculated suitable width critical height calculated different flow speeds numerical calculation carried using solidworks flow simulation present study realized steady state simulation results illustrated flow speed trajectory variation shear stress flow pressure different faces micro asperities turbulence area due geometry micro asperities localized prediction maximum wear area due skin friction also localized consideration shear stress variation
real time video processing challenge many embedded system applications general purpose processor based software custom single purpose processor based hardware software processor based rely mostly real time operating system layer allow multiple software threads run concurrently hardware processor based need layers executing programs rather operate finite state machines video capturing color space conversion privacy protection considered article three fundamental components effective secure real time video streaming system proposed model based concurrent finite state machines inherently concurrent careful verification proposed system compared base point system base point system built using soft core nios processor reconfigurable hardware fpga chip performance evaluations custom sequential machine designed modeled verilog hdl utilizes integer calculations concurrent interfaces input output memory devices synchronization purposes custom sequential machine design uses integer approximation rather floating point color space conversion speed factor orders magnitude higher base point system color space conversion base point system powerful enough serve real time video capturing processing privacy protection useful illustration need proposed system model
objective research focused race based rejection sensitivity race components racial identity intensify negative psychological reactions incident vicarious racism examined individual difference variables directly indirectly predicted african american students reactions trial george zimmerman killing african american teenager trayvon martin method study african american students completed measures race thought intrusions zimmerman trial outcome variables negative affect zimmerman trial forgiveness zimmerman study african american students completed measures racial identity centrality private regard public regard thought intrusions zimmerman trial negative affect forgiveness results study higher race either directly indirectly via thought intrusions related negative affect lower forgiveness study high racial centrality low public regard either directly indirectly via thought intrusions predicted negative affect lower forgiveness conclusions race specific components racial identity likely sensitize african americans incidents racism happen african americans leading negative psychological reactions events occur
study objectives examine surgical indications pathologic findings patients undergoing second surgery placement essure permanent birth control system determine role essure developing new onset pelvic pain design retrospective cohort canadian task force classification setting tertiary level hospital patients women essure placement subsequent second surgery intervention charts women undergoing pelvic surgery essure placement june june reviewed indication procedure surgical pathologic findings noted measurements main results patients second surgery essure placement surgical indication related pain remaining patients either new onset worsening pre existing pain new onset pain group surgical findings pathology consistent painful gynecologic condition remaining seemed related perforation migration essure device patients obvious cause new onset pain thus attributed essure microinsert conclusion essure sterilization associated new onset pain worsening pre existing painful gynecologic condition although rare careful complete consent placement thorough examination pain occur usually show etiology pain essure insert aagl rights reserved
multiple melanocytic naevi naevi one strongest risk factors melanoma however epidemiology adults unclear comprehensive dermatological status investigation birth cohort study cases aged years analysed prevalence multiple melanocytic naevi association sex socioeconomic status education childhood adulthood skin type sunbathing habits prevalence multiple melanocytic naevi higher education odds ratio confidence interval male sex sun sensitive skin type regular use sunscreen associated increased risk multiple naevi inflammatory skin diseases decreased risk multiple naevi conclusion several risk factors found multiple naevi among adults living high latitudes northern finland
provision healthcare creates significant environmental impacts mitigation attempted variety ways vary nation nation line differing policy priorities resource availability environmental performance hospitals enhanced example green building waste energy management product design however unpredictable occupant behaviour new research outcomes evolving best practice requires healthcare react respond ever challenging changing environment clearly one set actions appropriate jurisdictions many authors pointed negative environmental impacts caused healthcare studies focused particular aspects mitigation isolation reason optimal argued tackling impact mitigation whole system approach likely effective illustrate approach might entail practice evaluation systematic implementation impact mitigation ireland largest teaching hospital cork university hospital presented approach brings together voluntary initiatives particular emanating governmental non governmental organisations peer supports adaptation programmes designed originally environmental education purposes specific measures initiatives described analysis results planned future actions provides basis evaluation successes achieved achieving mitigation objectives crucial attribute approach retains flexibility connectivity time thereby ensuring continual responsiveness evolving regulation best practice green healthcare demonstrated implementation cork resulted mitigation existing impacts also commitment continual improvement systems approach widely adopted healthcare sector needs leadership regulators stakeholders strong supports cork found environmental education programmes especially action reward based programmes utilised campus academic affiliates particular university college cork especially effective framework address sustainability challenges developed however within healthcare implementation environmental initiatives must prioritise patient safety approach adopted delivery across health services sector ireland elsevier ltd rights reserved
popular approach analyzing survival data cox regression model cox model may however misspecified proportionality assumption may always fulfilled alternative approach survival prediction random forests survival outcomes standard split criterion random survival forests log rank test statistic favors splitting variables many possible split points conditional inference forests avoid split variable selection bias however linear rank statistics utilized default conditional inference forests select optimal splitting variable detect non linear effects independent variables alternative use maximally selected rank statistics split point selection conditional inference forests splitting variables compared value scale however instead conditional monte carlo approach used conditional inference forests value approximations employed describe several value approximations implementation proposed random forest approach simulation study demonstrates unbiased split variable selection possible however trade unbiased split variable selection runtime benchmark studies prediction performance simulated real datasets newmethod performs better random survival forests informative dichotomous variables combined uninformative variables categories better conditional inference forests non linear covariate effects included runtime comparison method proves computationally faster alternatives simple value approximation used copyright johnwiley sons ltd
scabies caused mite sarcoptes scabiei highly contagious parasitic disease affects millions people mammals worldwide calmodulin cam important calcium sensor participates various critical physiological processes study cam sarcoptes scabiei sscam cloned expressed sequence analyses performed using bioinformatics tools recombinant sscam rsscam used detect antigenicity using immunoblotting assays serodiagnostic potential rsscam assessed indirect enzyme linked immuno sorbent assay elisa calcium binding properties anilinonaphthalene sulfonic acid ans fluorescence rsscam also measured results indicated sscam contains open reading frame encodes polypeptide amino acids sscam expressed soluble protein multiple sequence alignment phylogenetic analyses indicated similarity genetic distance sscam species calcium binding properties ans fluorescence rsscam indicated typical calcium binding characteristics immunolocalizaton assay showed sscam widespread scabiei sscam based elisa exhibited sensitivity specificity detecting anti cam antibodies sera naturally infected rabbits findings study provide comprehensive molecular characterization sscam suggest rsscam inappropriate detecting scabiei results may also contribute future studies molecular characteristics cam parasites published elsevier ireland ltd
chemotherapeutic multidrug resistance mdr significant challenge overcome clinic practice several mechanisms contribute mdr one augmented drug efflux induced upregulation abcbi cancer cells regorafenib multikinase inhibitor targeting ras raf mek erk pathway approved fda treat metastatic colorectal cancer gastrointestinal stromal tumors investigated whether regorafenib overcame mdr mediated abcb results showed regorafenib reversed abcb mediated mdr increased accumulation paclitaxel abcbi overexpressing cells suppressing efflux activity abcb altering expression level localization abcb regorafenib inhibited atpase activity abcb mice bearing resistant colorectal tumors regorafenib raised intratumoral concentration paclitaxel suppressed growth resistant colorectal tumors regorafenib induce cardiotoxicity myelosuppression paclitaxel mice strategy reposition one fda approved anticancer drug regorafenib overcome resistance another fda approved widely used chemotherapeutic paclitaxel may promising direction field adjuvant chemotherapy study provides clinical rationale combination conventional chemotherapy targeted anticancer agents elsevier rights reserved
background evaluated outcomes totally endoscopic minimally invasive surgery atrial septal defect asd using glutaraldehyde treated autologous pericardial patch transcatheter interventional era methods results retrospectively reviewed consecutive patients underwent totally endoscopic asd closure glutaraldehyde treated autologous pericardial patch june april patients deferred catheter based intervention clinical anatomical reasons analyzed operative outcomes postoperative echocardiographic data mean age years patients women mean ratio pulmonary systemic flow six patients underwent concomitant tricuspid valve repair patients underwent concomitant atrial fibrillation surgery operative deaths median length hospital stay days postoperative echocardiography revealed trivial residual shunt patient follow period interventions asd readmission heart failure follow echocardiography revealed recurrent shunt calcification autologous pericardial patch conclusions totally endoscopic asd closure glutaraldehyde treated autologous pericardial patch demonstrated excellent outcomes useful option patients unfavorable anatomy reasons excluding transcatheter intervention
geotextile reinforced embankments deep cement mixed dcm columns widely used construction highway embankments soft clay low shear strength high compressibility numerical modeling based fem widely used investigate behavior embankments construction serviceability incorporating consolidation foundation soil time however much attention paid strain softening behavior dcm columns beyond yield essential ultimate limit state computations determine stability embankments failure columns paper presents constitutive model extension mohr coulomb model simulations strain softening behavior cement admixed clays model validated using triaxial test data found literature cement admixed singapore hong kong marine clays ariake clay two dimensional coupled mechanical hydraulic numerical implementation geotextile reinforced dcm column supported grcs embankment constructed soft soil finland carried incorporating strain softening behavior dcm columns even though isolated columns overlapped column walls used embankment yield significantly service loads model simulations show good agreement field data confirming capability plane strain finite element model predicting grcs embankment behavior finally finite element model strain softening dcm columns used investigate progressive failure typical hypothetical grcs embankment isolated columns square pattern results clearly illustrate bending failure mode caused progressive softening dcm columns including plastic hinge development within columns american society civil engineers
background hands training point care ultrasound poc ideally comprise bedside teaching well simulated clinical scenarios high fidelity phantoms portable ultrasound simulation systems commercially available however considerable costs limits suitability medical schools linux based software emergency department ultrasound simulation edustm developed kulyk olszynski feasibility poc education well documented shows good acceptance important limitation even widespread use edus however may due need virtual machine windows systems aim adapt original software toward html based solution thus making affordable applicable simulation setting methods created html browser based ultrasound simulation application reads input different sensors triggering ultrasound video displayed respective device rfid tags nfc tags codes integrated training phantoms attached standardized patients rfid antenna hidden mock ultrasound probe application independent respective device results application used successfully different trigger scanner combinations mounted readily simulated training scenarios application runs independently operating systems electronic devices conclusion low cost browser based ultrasound simulator easy build adaptive independent operating systems potential facilitate poc training throughout world especially resource limited areas
bioengineering course offered senior students mechanical engineering major elective penn state behrend first semester senior year average around students enroll project based course grade depends three comprehensive group projects one design bone plate fractured femur grade comes individual application presentation discussing different circumstances concepts mechanical engineering applied solve analyze biomedical problems background physiology introduced class majority applicable engineering knowledge learned prerequisite courses statics dynamics strength materials system dynamics etc finite element analysis fea elective offered semesters senior year prerequisite bioengineering course students enrolled bioengineering course either fea course taking fea concurrently therefore spite popularity areas related biomechanics thus far fea incorporated bioengineering course previously fractured femur project utilized applicable theoretical analyses including statics strength materials materials machine design fall instructor bioengineering course made effort fea study femur ensuing presentation completed willing student student taking fea simultaneously bioengineering scheduled present last week semester instructor fea wrote introductory manual fea procedures analyze healthy femur using cad model femur student used manual initiate fea study fractured femur major challenge student complicated loading assembly feature bone plus addition bone plate several week struggle independent learning guided faculty members bioengineering fea student able accomplish fea analysis presented results class discrepancy fea results theoretical analysis shown less results presentation also included fea results diverse realistic loading boundary conditions since students finished fractured femur project actively participated meaningful discussion presentation completion project demonstrated feasibility importance incorporating fea bioengineering course addition presenting student able complete working manual fea analysis fractured femur passed future students course plan include fea project bonus activity regarding formation project teams instructor would appoint member enrolled fea course assignment project based present fea study femur also incorporated fea course offered campus
combined effects hydrometeor scattering absorption result significant power loss earth space microwave links operating frequencies ghz increasing deployment higher frequencies commercial wireless networks accurate estimation specific rain attenuation significant reliable design radio communication system present paper scattering plane electromagnetic wave pruppacher pitter raindrop treated using method auxiliary sources mas obtained data compared taken open literature form real imaginary part forward scattering amplitude excellent results used numerical calculation specific rain attenuation exceedance probability function case hypothetical satellite link located various climatic regions comparison models experimental data given encouraging results
age critical factor prevalence tauopathies including alzheimer disease observe aging phenotype interacts affects pathological intracellular accumulation hyperphosphorylated tau tauopathy mouse model expressing mutant human tau back crossed ten times onto senescence accelerated samp background establish new strain sapt unlike samp mice mice characterized robust tau pathology particularly amygdala hippocampus analysis age matched sapt mice revealed pathological tau phosphorylation increased brain regions compared parental strain moreover revealed immunohistochemistry phosphorylation critical tau phospho epitopes ser ser ser significantly increased amygdala sapt mice age dependent manner suggesting age associated effect tau phosphorylation anxiety tests revealed older cohort sapt mice months months exhibited behavioural pattern similar observed age matched tau transgenic mice samp parental mice learning memory however appeared governed accelerated aging background samp strain ages investigated samp sapt mice showed decreased learning capacity compared mice therefore conclude accelerated aging exacerbates pathological tau phosphorylation leading changes normal behaviour findings suggest sapt mice may useful novel model study role complex geriatric phenotype tauopathy
idea taking inspiration nature particular living systems design technological systems fairly widespread originated much research work however field materials approach allowed construction systems high complexity time inexpensive able mass produced idea wider context natural systems necessarily optimized seems justified optimization must confused evolution darwin understand finalism evolutionary processes mechanism producing design living organisms result optimal designs fulfil given task cause continuous adaptation environment similarly unfounded seems idea machines devices necessarily better obtained using traditional design approach designed taking inspiration nature trial error approach supported principles bionics represents setback respect application scientific principles technology much contributed technological advancement modern world
purpose indoor tanning increases risk melanoma particularly common among young adult women also linked psychiatric symptoms frequent tanning may indicate tanning dependence addiction associated endorphin release ultraviolet radiation exposure objective current study investigate associations tanning dependence psychiatric substance use symptoms young adult women design cross sectional survey psychiatric interview setting online except mini international neuropsychiatric interview mini completed telephone subjects participants female university students aged years measures mini seasonal scale index tanning dependence scales reporting ever used tanning bed booth tanning lamps single item reporting smoking cigarette last days single item analysis descriptive statistics chi analysis multivariate logistic regression results forty six percent sample reported history classified tanning dependent multivariate logistic regression analyses showed significantly associated symptoms alcohol use disorders generalized anxiety social anxiety tanning dependence associated symptoms alcohol use disorders conclusion tanning concern association skin cancer association psychiatric substance use symptoms young women certain psychological problems may seek relief symptoms findings suggest indoor tanners may benefit health behavior psychosocial interventions
paper electric bicycle motor design study presented according related standard fundamental dimensions characteristics kept within certain boundaries means motor rated power physical constraints arising standard bicycle sizes available market slot pole ratios winding configurations investigated comprehensively order obtain proper design electric motor due facts pedal assisted electric bicycle application defining motor parameters materials used motor design optimisation attempts undertaken using analytical solver employing numerical calculations finite element method fem analyses motor designs assessed based torque production weigh efficiency ease manufacture concise experimental study conducted prototype motor order evaluate validity design study
plastic wastes particularly polyethylene terephthalate pet generated used bottled water constitute worldwide environmental issue reusing pet waste geotechnical applications reduces environmental burdens handling waste also improves inherent engineering properties soil paper investigated factors affecting shear strength improvement pet mixed residual soil four variables considered plastic content plastic slenderness ratio iii plastic size soil particle size series unconfined compression tests performed determine optimum configurations promoting shear strength improvement results showed optimum slenderness ratio pet content shear strength improvement respectively large pet pieces favorable fine grained residual soil small pet pieces favorable coarse grained residual soil higher shear strength improvement obtained pet mixed coarse grained residual soil fine grained residual soils orientation plastic pieces soil frictional resistance developed soil particles pet surface two important factors affecting shear strength performance pet mixed soil
aging associated higher propensity false memories decreased retrieval previously studied items young adults perform lateralized version deese roediger mcdermott drm paradigm right cerebral hemisphere sensitive left false memories suggesting hemispheric imbalance cerebral mechanisms supporting semantic episodic memory processes since cerebral asymmetries tend reduced age surmised behavioral asymmetries generation false memories would diminished aging probe hypothesis lateralized version drm paradigm administered healthy older adults encoding phase lists semantically associated words memorized retrieval session targets previously seen words lures never seen strongly semantically related words distracters never seen unrelated words briefly displayed either left right visual fields thus primarily stimulating respectively participants decide whether word previously studied old new also whether strong episodic recollection remember mere feeling familiarity know old words line predictions false memories globally higher vivid false recollections remember responses higher presented additionally found significant correlations participants familiarity scores leftward attentional bias previously evidenced using visuospatial landmark task schmitz peigneux effect present result line hypothesis interplay attentional resources allocated visuospatial memory processes suggesting memory pseudoneglect phenomenon would altered aging elsevier ltd rights reserved
optimal sizing residential photovoltaic generation energy storage systems timely issue since government polices aggressively promote installing renewable energy sources many countries small sized systems recently developed easy use residential areas paper investigate problem finding optimal capacities systems context home load management smart grids unlike existing studies optimal sizing treated part designing hybrid energy systems polygeneration systems stand alone connected grid fixed energy price model explicitly considers varying electricity price result individual load management customers market problem formulated day capacity planning problem goal minimize overall expense paid customer planning period overall expense sum expenses buy electricity install days since customer wants minimize monetary expense objectives look conflicting first regard problem multi objective optimization problem additionally secondly formulate problem day noncooperative game customers solved distributed manner thus better fit pricing practice smart grids order converging result best response game use called proximal point algorithm numerical investigation find pareto efficient trajectories problem converged game theoretic solution shown mostly worse pareto efficient solutions
inequalities health indicators among different ethnic groups living region receiving medical services anemia global problem although prevalence anemia high israel differences among ethnic groups studied objective assess anemia among bedouin jewish women childbearing age southern israel retrospective observational study conducted based data computerized medical records seven thousand eight hundred seventy one women study clinics underwent complete blood counts blood hemoglobin levels jewish patients older years practiced birth control adhered bedouin women children bedouin women pregnant study period prevalent types anemia iron deficiency anemia chronic disease two types anemia proportionally higher among jewish women anemia chronic disease adherence rates treatment low three factors associated severe anemia hemoglobin bedouin odds ratio use birth control pregnancy bedouin woman risk factor severe anemia adherence treatment anemia low groups findings addressed national program reduce health inequalities
across six studies examine magnitude expressed happiness influences social perception interpersonal behavior find happiness evokes different judgments expressed high levels expressed moderate levels judgments influence opportunistic behavior specifically people perceive happy individuals naive moderately happy individuals perceptions reflect belief happy individuals shelter negative information world result inferences happy people relative moderately happy people likely receive biased advice advisors conflict interest likely chosen negotiation partners opportunity exploitation salient findings challenge existing assumptions organizational behavior psychology identifying significant disadvantage expressing happiness underscore importance examining emotional expressions different magnitudes call future work explore emotion experienced expressed different levels influences judgment behavior published elsevier inc
purpose immunoproteasome known generate peptides antigen presentation however also proposed additional functions stress response propensity immunoproteasome degradation oxidatively damaged proteins peptides makes interesting context cataract formation prevention study hypothesized immunoproteasome present human cataractous lenses oxidative stress induce expression affect proteolytic activity intracellular location native cultured human lens epithelial cells hlecs methods expression immunoproteasome constitutive proteasome subunits beta beta beta beta beta beta studied using western blotting chymotrypsin like activity investigated possible oxidative stress response inhibitors specific immuno constitutive proteasome onx respectively used study relative contributions total proteasome activity intracellular location proteasomal subunits beta beta studied immunocytochemistry results immunoproteasome subunits detected lens epithelium lens fibers derived cataract surgery oxidative stress cultured hlecs upregulated immunoproteasome constitutive proteasome chymotrypsin like activity decreased increased oxidative stress two proteasome types contributed equally total proteasome activity immunocytochemical labeling subunit beta showed mainly cytosolic localization whereas subunit beta localized predominantly nucleus induced challenge increased expression immunoproteasome conclusions present findings indicate role immunoproteasome oxidative stress management lens
better understand sleep wake dysregulation affects alzheimer disease compared cerebrospinal fluid csf orexin histamine tele methylhistamine mha levels patients probable high level evidence mild cognitive impairment mci due neurologic disorders ond controls determined relationships biomarkers csf biomarkers concentrations clinical sleep profile csf orexin mha levels higher mci ond controls csf orexin correlated csf amyloid beta mci independently age gender mmse total tau phosphorylated tau sleep parameters nighttime sleep duration longer mci patients controls mci nighttime sleep duration negatively correlated csf amyloid beta mmse conclude csf orexin thma upregulated correlated amyloid beta level data suggested change sleep wake pattern early stage disease needs investigation deeply explain mechanistic interplay sleep alzheimer elsevier inc rights reserved
vitiligo complex systemic disease associated many autoimmune auto inflammatory conditions additionally cutaneous changes vitiligo significant effects quality life self esteem efforts needed increase understanding vitiligo comorbidities well increase awareness psychological effects vitiligo
seismic performance self anchored suspension bridge three tower investigated three dimensional nonlinear finite element model bridge developed using sap nonlinear time history analysis conducted using fast nonlinear analysis method fna beam column effect nonlinear behavior bearing damper taken consideration analyze results showed middle tower vulnerable compared two side towers existed risk buckling composite beam vulnerable part lied near steel concrete composite segment viscous dampers effective reduce seismic response towers well girders
currently privatized state owned taiwan power company taipower monopoly energy production vertically integrates electricity market taiwan geographical environments economies scales social structures diverse political ideologies taiwan electricity market exhibits unique characteristics maximize benefits electricity liberalization future market operations must involve conventional considerations economic dispatch overall social welfare included incorporating perspectives fairness responsibility environment key electrical grid operations executed appropriately responded future market liberalization planning including factors environmental effects government policies addition electrical line construction operation cost factors involved entire operational model planning basis responsibility sharing study used simulated responsibility three phase pricing method proposed pricing method expected help attain following policy goals achieving reasonable power price allocations simultaneously ensuring fair efficient electric grid operation changing operation orientations power plants electrical grid facilities increasing rate renewable energy use
background studying sleep alcohol dependent patients beginning course abstinence earlier studies interest current study focused direct effect doses alcohol blood alcohol level bal healthy sleep first polysomnographic study testing impact doses alcohol ingestion thus reflecting normal social drinking alcohol abuse single blind randomized design healthy volunteers study evaluated short term acute drinking period days withdrawal alcohol polysomnographic variables also subjective estimates sleep quality mehods crossover design week interval healthy subjects received alcohol raise blood alcohol either bal bedtime consecutive nights alcohol free baseline night objective polysomnography subjective sleep questionnaires recorded night following days alcohol discontinued simultaneous measurements sleep gauge withdrawal effects results dose alcohol leading bal clear effects could detected following evening bal hypnotic like effect shortened sleep latency reduced number wake periods decreased stage sleep occurred primarily first half night signs rebound effects already present second half night increased stage sleep dose alcohol significantly increased slow wave sleep sws first half night reduced rem density beginning night discontinuation higher alcohol dose rem sleep amount increased significant withdrawal rebound effects could observed parameters sleep continuity nights discontinuation alcohol bal conclusions owing small sample size results study need interpreted caution short term moderate alcohol consumption bal significantly alter objective subjective parameters sleep higher doses alcohol resulting bal level immediately going bed mainly influenced sleep first half night resembling effects short acting hypnotic drug including suppression phasic aspects rem sleep rem density interestingly analysis latter part nights indicated immediate presence withdrawal effects increased light sleep statistically significant effects sleep parameters observable nights withdrawal alcohol higher bal interpreted carefully data indicate negative effects sleep occur already short term use alcohol doses bal despite hypnotic like effects first hours sleep especially latter part night
atlas software computing period intensive evolution current long shutdown presents opportunity assimilate lessons successful run prepare substantially increased computing requirements run spring run bring near doubling energy data rate high event pile levels higher event complexity detector upgrades meaning number complexity events analyzed increase dramatically time operational loads must reduced greater automation wider array opportunistic resources must supported costly storage must used greater efficiency sophisticated new analysis model must integrated concurrency features new processors must exploited paper surveys distributed computing aspects upgrade program plans exercise new capabilities large scale data challenge
subdivision surfaces common tool geometric modelling especially computer graphics computer animation nowadays concept become established engineering focus quadrilateral control grids generalized spline surfaces catmull clark subdivision type classical theory subdivision surface defined limit repetitive application subdivision rules control grid based stam idea labour intensive process avoided using natural parameterization limit surface however simplification free defects singularities smoothness classically defined limit surface lost paper describes rescue parameterization using subdivision basis function consistent classical definition expensive compute based introduce characteristic subdivision finite element use discretize integrals subdivision surfaces show integral representation complicated parameterization reduces decisive factor compare natural characteristic subdivision finite element approach solving pdes surfaces model problem consider mean curvature flow whereby computation done step step changing geometry elsevier ltd rights reserved
breast cancer associated estrogen progestin therapy may favorable characteristics cancer never users results conflicting well known either whether body mass index bmi modifies association investigated breast cancer characteristics users lean bmi overweight women bmi icelandic cancer detection clinic cohort information breast cancer risk factors icelandic women linked population based icelandic cancer registry total women invasive breast cancer diagnosed years older matched controls cohort conditional logistic regression used estimating adjusted odds ratios confidence intervals according tumor characteristics stratified bmi polytomous logistic regression applied case analysis testing whether risk associated use differed according tumor characteristics ever users twofold higher risk breast cancer compared never users lean women use significantly less likely associated grade tumors grade tumors contrary overweight women risk increased irrespective grade use overweight women associated higher risk lobular ductal cancer among lean users tumor characteristics favorable among never users effect observed overweight women
fifty years end algerian war independence french colonization algeria still controversial topic sporadically brought forefront public sphere one way better understand current intergroup relationships french french origin french algerian origins investigate past influences present study explores french students emotional reactions historical period ideological underpinnings relationship willingness compensate past misdeeds prejudice results show french students french ascendants endorse remorse norm thinking past colonization algeria express low levels collective guilt moral outrage related emotions especially students right wing political orientation national identification form glorification country group based emotions significantly related pro social behavioral intentions willingness compensate prejudice toward outgroup
analog front end afe multifunction environmental sensor proposed afe designed able sense level signals low frequency band around consists instrumentation amplifier charge amplifier continuous time delta sigma delta sigma adc reduce low frequency noise operational amplifier opamp used signal path paper proposes weak inversion biasing technique designed achieved nvrms input referred noise irn band die area designed achieved acrms irn charge sensing mode farms irn current sensing mode band respectively occupies die area afe fabricated cmos process die area current consumption khz output data rate odr reducing odr
paper focuses quality improvements clinching joints using servo press radial basis function neural network sliding mode rbfs control strategy bottom thickness affected press punch position usually used monitor clinching joint quality traditional clinching presses driven pneumatic pistons motors provide feedback punch force motor position however feedback indirectly related joint bottom thickness clinching workers set control parameters presses depend tests statistics thus paper presents servo press system utilizes punch position feedback directly control joint bottom thickness transmission errors considered movement accuracy servo press mathematical model servo press established analyzing algorithm combines rbf neural network sliding mode proposed applied press position tracking algorithm adopts rbf neural network approximate nominal model press system update law algorithm based lyapunov function used prove stability closed loop system sliding mode controller compensates neural network error disturbance finally experiments executed servo press rbfs controller evaluate performance proposed method fuzzy pid controller also applied press comparison results indicate servo clinching press system rbfs efficiently accurately control clinching jointing process
dynamic characteristics assumed isolated cfrp main cable studied section area cfrp cable determined suspension bridge different spans sag span ratios based principle limit design given security coefficient irvine parameter suspension bridge backstay without backstay calculated rule irvine parameter linearly changed span sag ratio respectively found analysis frequency change span shows first third symmetric frequency lager less corresponding antisymmetric frequency respectively second symmetric antisymmetric frequencies close analysis frequency dimensionless frequency change sag ratio show bridge without backstay first third order symmetric frequencies larger less corresponding antisymmetric frequencies respectively bridge without backstay crossover phenomenon happens second symmetric mode changes two four internal nodes mode
vermis spinocerebellum receives input spinal cord motor cortex controlling balance locomotion longitudinal hemisphere region cerebro cerebellum interconnected non motor cortical regions including prefrontal cortex underlies decision making noradrenaline release cerebellum known important motor plasticity less known plasticity cerebellar noradrenergic system characterized plasticity dopamine beta hydroxylase immunoreactive fibers cerebellum adolescent female rats evoked voluntary wheel running food restriction combination days wheel access combined last days responded excessive exercise choosing run even hours food access exacerbated weight loss beyond due alone vermis exercise without shortened inter varicosity intervals increased varicosity density along fibers excessive exercise due also shortened fibers contrast hemisphere required evoked excessive exercise evoke shortened inter varicosity intervals along fibers change exhibited strongly rats suppressed evoked excessive exercise behavior minimized weight loss presuming shortened inter varicosity intervals translate enhanced release synthesis norepinephrine enhancement cerebellar hemisphere may contribute towards protection individuals life threatening activity based anorexia via relays higher order cortical areas mediate animal decision suppress innate evoked hyperactivity
aims study determine incidence risk factors thrombosis bleeding polycythemia vera patients research effects risk factors survival medical records patients analyzed retrospectively patients divided groups according whether thrombosis developed follow according whether bleeding occurred follow mean age diagnosis years mean follow period months percentage cases thrombosis events occurred diagnosis follow respectively comparisons disease duration average thrombosis risk score groups without thrombosis drew statistically significant results patient history thrombosis thrombocytosis first visit found significant effect thrombosis recurrence major bleeding rate post myelofibrosis independent risk factor bleeding major cause death among patients study primary thrombosis important causes mortality among patients thrombosis prominent risk factors thrombosis development disease duration high thrombosis risk scores thrombocytosis patients history thrombosis may cause thrombosis recurrence follow period
optical character recognition ocr main research topic computer vision artificial intelligence extend applications detection text area video image contents taken camera devices retrieval text information area paper aims implement binarization algorithm removes user intervention provides robust performance outdoor lights using tophat algorithm channel transformation technique study particularly concentrate text information outdoor signboards validate proposed technique using data
plasmonic materials possessing dense hot spots high field enhancement large area highly desirable ultrasensitive biochemical sensing efficient solar energy conversion particularly based low cost noncoinage metals high natural abundance considerable practical significance aluminum hybrid nanostructures hnss high density plasmonic hot spots across large scale fabricated via highly efficient scalable nonlithographic method millisecond laser direct writing liquid nitrogen nanosized alumina interlayer induces intense dual plasmonic resonance couplings adjacent nanoparticles bimodal size distribution within hybrid assemblies leading remarkably elevated localized electric fields hot spots accessible analytes reactants stacked nanostructure substantially raises hot spot density giving rise plasmon enhanced light harvesting deep visible strong enhancement raman signals low limit detection outperforming reported nanostructures even comparable noble metals combined long term stability good reproducibility hnss hold promise robust low cost plasmonic material applications plasmon enhanced spectroscopic sensing light harvesting
macrophage lipoprotein lipase lpl induces lipid accumulation promotes atherosclerosis however effects lipoprotein hydrolysis products generated lpl macrophage derived foam cell formation clearly understood thus analyzed transcriptomic response hydrolysis products via microarray analyses rna isolated human thp macrophages incubated total lipoprotein hydrolysis products generated lpl expression transcripts significantly upregulated transcripts significantly downregulated bioinformatics analyses revealed significant representation genes involved cell cycling stress response type interferon signaling cellular metal ion homeostasis sterol metabolism nuclease activity interestingly transcripts small nucleolar rna significantly upregulated verified microarray data quantitative real time pcr found expression snora well expression genes associated cell cycle pcna dkc variant stress response atf type interferon signaling ifitm lipid metabolism plin significantly affected lpl hydrolysis products determine free fatty acid ffa component total lipoprotein hydrolysis products sufficient alter expression genes thp macrophages also incubated total ffa individual classes ffa component gene regulation ffa component mimic hydrolysis products suggesting regulation gene expression thp macrophages depends specific combination concentration lipid species present hydrolysis products solely ffa
article explores difference time series property economic output great china economic area gcea mainland china hong kong taiwan using powerful kim perron unit root test real gdps period study sample results indicate presence break economies corresponds asian financial crisis additionally allowing break leads rejection unit root hypothesis taiwan important implications provided first considering presence break testing nonstationarity important false conclusions drawn second given stationarity gdp found taiwan investors look beyond local economic shocks focus world economy development investing taiwan contrast investors mainland china hong kong pay attention shock likely persistent third relevant authorities recognize government policy intended promote long run economic growth may ineffective taiwan whereas effective mainland china hong kong
lactobacilli important intestinal homeostasis involves regulation immune function digestive health cholesterol absorption intestinal tumor growth amongst others previous investigations suggested oral intake heat killed lactobacillus brevis brevis sbc sbl suppresses dermatitis modulating immune function atopic dermatitis mouse model aim present study investigate effect heat killed brevis sbc intake skin hydration conditions humans randomized double blind placebo controlled study conducted volunteers slightly higher levels transepidermal water loss tewl forearm subjects people aged years randomly allocated three groups level tewl age distributed equally among groups subjects took placebo heat killed brevis sbc daily dose weeks following exclusion eight subjects plausible reasons two withdrawals study two study violations one meeting exclusion criteria three due physical condition subjects subjected analysis results present study revealed following analysis whole populations marginal differences observed tewl example suppression skin water loss neck day group week lower eye region day group week respectively compared placebo group analyzed dunnett test significant increase corneal hydration also observed neck day group week compared placebo group analyzed dunnett test analysis subpopulations whose habitual frequency taking lactic fermentation products less per week levels corneal hydration neck day group lower eye region day group significantly increased week conclusion results present investigation suggest oral intake heat killed brevis sbc effective improving skin hydration conditions populations low habitual frequency taking lactic fermentation products
skeletal muscle development vertebrates also termed myogenesis highly integrated process evidence date indicates processes similar across mammals poultry fish although timings various steps differ considerably myogenesis regulated myogenic regulatory factors consists two three distinct phases different fibre populations appear critical times myogenesis prone hormonal environmental influences depend largely developmental stage one main mechanisms genetic environmental effects muscle fibre development via direct action growth hormone insulin like growth factor igf axis mammals poultry postnatal growth function muscles relate mainly hypertrophy fibres formed myogenesis fibre type composition terms metabolic contractile properties whereas fish hyperplasia still plays major role candidate genes important skeletal muscle development instance encode igfs igf binding proteins myosin heavy chain isoforms troponin myosin light chain others identified mammals nutritional supply utero affects myogenesis igf axis may indirect action partitioning nutrients towards gravid uterus impaired myogenesis resulting low skeletal myofibre numbers considered one main reasons negative long term consequences intrauterine growth retardation severe undernutrition utero due natural variation litter twin bearing species insufficient maternal nutrient supply may impair myogenesis adversely affect carcass quality later terms reduced lean increased fat deposition progeny hand increases maternal feed intake standard requirement seem beneficial effects growth progeny myogenesis slightly affected initial studies low high maternal protein feeding published although studies first results also reveal influence nutrition skeletal muscle development fish poultry finally environmental temperature identified critical factor growth development skeletal muscle fish poultry
educational attainment important often overlooked contributor health outcomes patients kidney disease lower levels education increased risk esrd complications peritoneal dialysis worse transplant outcomes mortality mediators associations poorly understood involve complex interplay health knowledge behaviors socioeconomic psychosocial factors interventions targeting aspects care potential reduce disparities related educational attainment however programs described specifically address issue future research efforts systematically assess level educational attainment also report differential impact interventions across educational strata addition routine measurement health literacy may useful identify high risk patients independent years schooling better understanding influence educational attainment kidney health provides opportunity improve care outcomes vulnerable patients kidney disease national kidney foundation inc rights reserved
background type narcolepsy characterized symptoms believed represent rapid eye movement rem sleep stage dissociations occurrences features wake rem sleep intermingled resulting mixed state hypothesized sleep stage dissociations objectively detected analysis nocturnal polysomnography psg data affecting rem sleep used diagnostic feature narcolepsy new method linear discriminant analysis lda model using features extracted eog emg eeg used control subjects select features differentiating wake stage rem sleep sleep stage differentiation next represented projection features characteristic sleep stage differences estimated residual sleep stage probability space using model evaluated psg data non narcoleptic subjects lda classifier used determine best separation plane comparison existing methods method replicates specificity sensitivity training set validation set better many methods results eight prominent features could differentiate narcolepsy controls validation dataset using composite measure specificity cut training dataset sensitivity specificity sensitivity validation set using hypersomnia subjects specificity sensitivity analyzing treated narcoleptics specificity sensitivity conclusion sleep stage dissociation used diagnosis narcolepsy however use medications presence undiagnosed hypersomnolence patients impacts result elsevier rights reserved
study authors use infrared stealth theory phase change materials development multispectral stealth composites study results showed form kind hierarchical structured multispectral stealth composites achieve good multispectral stealth effects visible light thermal infrared radar electromagnetic laser acoustic band etc technical processing base material phase change materials
curriculum structure responsible largely success post secondary vocational education according survey among graduated students local employers top skills required students cad short computer aided design cam short computer aided manufacturing engineering major abilities use cad applications engineering design production suggested core curriculum based educational program aiming enhance employability flexibility students thus promote china post secondary vocational education improvement
experiment conducted study effect four different management techniques enhance colostrum intake piglet litter performance treatments performed piglets born weighing less within birth control group con split nursing litter allowing piglets free access teats split oral supplementation sow colostrum piglets litter col oral supplementation energy product calostrene piglets litter thirty nine primiparous sows large white landrace litters piglets multiparous sows litters piglets used litters fixed piglets piglets weighed lactation mortality recorded primiparous sows oral supplementation col enhanced piglets bodyweight day compared con split however differences observed day litter total pre weaning mortality nonetheless lower piglets mortality rate found con compared split col groups primiparous sows multiparous sows differences among treatments observed piglets day day primiparous sows piglets higher day multiparous sows piglets colostrum supplementation low birth weight piglets improved early weight gain piglets born primiparous sows probably enhancing colostrum intake affect piglets weaning pre weaning mortality
paper presents novel implementation adaptive robust second order sliding mode control arssmc mobile robot four mecanum wheels wheel mobile robot actuated separate motors first time higher order sliding mode control method implemented trajectory tracking control mecanum wheeled mobile robot kinematic dynamic modeling robot done derive equation motion presence friction external force disturbance uncertainties order make system robust second order sliding mode control law derived adaptive laws defined adaptive estimation switching gains check tracking performance proposed controller simulations performed comparisons obtained results made adaptive robust sliding mode control arsmc pid controller addition new low cost experimental approach proposed implement proposed control law real robot experimental results prove without compromising dynamics robot real time implementation possible less computational time simulation experimental results obtained confirms superiority arssmc arsmc pid controller terms integral square error ise integral absolute error iae integral time weighted absolute error itae control energy total variance
paper presents personalised approach participatory design several aspects project brief process artefacts left open redefined participants accordance individual needs preferences availabilities drawing upon person centred dementia care values personalisation seen invitation people dementia families participate also way dealing uniqueness participants providing opportunities meaningful communication social relationships maintained approach emerged specificity involving people dementia families participatory design project effort best include respectful convivial manner relations use design participation constant negotiation participants analysed qualities personalised participation relating ethics empathy conviviality outlined
cutaneous cell lymphomas ctcl characterized presence chronically inflamed skin lesions containing malignant cells early disease presents limited skin patches plaques exhibits indolent behavior many patients disease never progresses beyond stage approximately one third patients disease becomes progressive skin lesions start expand evolve eventually overt tumors develop malignant cells may disseminate blood lymph nodes bone marrow visceral organs often fatal outcome transition early indolent progressive advanced disease accompanied significant shift nature tumor associated inflammation shift appear epiphenomenon rather critical step disease progression emerging evidence supports malignant cells take control inflammatory environment suppressing cellular immunity anti tumor responses promoting chronic inflammatory milieu fuels expansion review inflammatory changes associated disease progression ctcl point wider relevance cancer contexts define term malignant inflammation pro tumorigenic inflammatory environment orchestrated tumor cells discuss mechanisms driving development malignant inflammation ctcl
affective lability instability emotional states associated heightened levels trauma related emotional responding posttraumatic stress disorder ptsd symptoms however impact affective lability specifically habituation idiographic trauma cues yet examined among trauma exposed individuals current study examined differential response trajectories trauma related imaginal exposure function affective lability specifically women history sexual victimization participated laboratory based study involving single session repeated imaginal exposures idiographic traumatic event cues hypothesized participants higher affective lability reported less reduction trauma cue elicited posttraumatic stress symptoms across exposure trials given results important continue extend laboratory findings better understand elevated affective lability related response trauma focused exposure therapy among individuals ptsd trauma related psychopathology borderline personality disorder elsevier ltd rights reserved
complex dynamic engineering systems radar gimbal missile infrared sensors land vehicles aircraft ships power plants become challenges classical fault diagnostic system modular consisting modules line replaceable units lru module bit circuit linked system level bit bit architecture performance characteristic diagnostic system sensitivity specificity usually poor fault diagnostic systems plagued conditions known false alarm missed detection duplicate cnd retest rtok adverse impacts performance reliability maintainability availability safety affordability costly elusive problems may due many reasons absence lack fault modeling threshold design absence lack test verticality unobservable uncontrollable modes state variables system state space model signal detection theory techniques sdtt fit general scheme classical fault diagnostic bit threshold design signal detection theory models lend readily numerical computations suitable solution computer applicable classical bit testability threshold design nevertheless several mathematical strategies must used one apply sdtt bit detection since sdtt reliable many fields radar detection application medicine diagnostic tests biometrics well valuable tool bit threshold design mathematical manipulations paper presents foundations sdtt radar target detection theory coherent manner easy follow way advance bit diagnostic threshold design time emphasizes underlying physics techniques make use gaussian distribution bayesian statistics important performance measures sensitivity specificity prevalence paper addresses well test verticality issue introduce unobservable uncontrollable state variable issues however state observability state controllability beyond scope paper fully addressed control engineering model based fault diagnostic research task
splenic irradiation palliative treatment option symptomatic splenomegaly pain early satiety pancytopenia sequestration secondary hematologic malignancies disorders purpose current article review literature hematologic malignancies disorders including patient selection optimal technique efficacy toxicities picos prisma methods used select articles including courses patients common cancers treated included chronic lymphocytic leukemia myeloproliferative disorders common regimen fractions two weeks patients received retreatment partial complete response symptoms lab abnormalities obtained treated patients retreated within months correlation biologically equivalent dose radiation therapy response duration pain relief spleen reduction cytopenia improvement therefore lower doses fractions may effective higher doses grade toxicity typically leukopenia infection noted courses grade toxicity courses grade toxicities due either thrombocytopenia hemorrhage leukopenia sepsis combination sequelae cancer directly caused summary generally safe efficacious method treating patients symptomatic splenomegaly elsevier ltd rights reserved
modern residents yucatan mexico blend traditional maya beliefs pantheon ancient gods supernatural forces recent catholic traditions flowing centuries spanish colonial influence paper compares contrasts four modern rituals yucatec maya village telchaquillo yucatan rite associated local cenote limestone sinkholes along caves serve accesses maya underworld homes gods research suggests considerable cultural continuity ancient residents postclassic maya center mayapan cenotes regularly paired important ritual architecture sometimes contain human remains indications ritual activity ceremonies documented paper provide information maya cosmology gender roles long held beliefs cenotes agricultural fertility
paper performs generalized steadystate analysis various developed series cascade boost converters based switching signal flow graph sfg method unified switching model constructed applied circuits effects caused diodes considered applications example proposed generalized analytical method shows advantages high convenience practicability experimental results provided support theoretical analysis
rapid development internet especially development mobile internet network size network infrastructure changes especially random access node detect network attacks challenges traditional detection algorithm using neural networks calculated volume increased dramatically detection accuracy high problem use stochastic process theory hidden markov chain transformation neural network convergence substantial decline improving network attack detection accuracy degree
acth dependent hypercortisolism caused pituitary adenoma cushing disease common cause endogenous cushing syndrome often associated several morbidities including hypertension diabetes osteoporosis bone fractures secondary infections increased cardiovascular mortality majority approximate corticotrophinomas visible pituitary magnetic resonance imaging microadenomas mics increased growth potential invasiveness exceptionally exhibiting malignant demeanor addition larger invasive macs associated significant increased risk local complications hypopituitarism visual defects given clinical molecular heterogeneity corticotrophinomas aim study investigate pattern genetic differential expression mic mac including invasiveness grade criterion categorizing tumors study included tumor samples patients clinical laboratorial radiological histopathological diagnosis hypercortisolism due acth producing pituitary adenoma differential gene expression studied using affymetrix microarray platform corticotrophinomas classified non invasive mic mac invasive mac according modified hardy criteria somatic mutations usp also investigated none patients exhibited usp variants differential expression analysis demonstrated non invasive mic mac similar genetic signature invasive macs exhibited differential expression profile among genes differentially expressed highlighted ccnd znf dapk timp differential expression validated quantitative real time pcr another cohort non invasive invasive cortocotrophinomas also identified potential biological pathways associated growth invasiveness tgf beta protein signaling pathways dna damage response pathway pathways associated focal adhesion study revealed differential pattern genetic signature subgroup mac supporting genetic influence corticotrophinomas patients
background mono polysensitization different ige mediated allergic phenotypes children allergic sensitization associated allergic asthma allergic rhinitis however associations sensitization pattern particularly polysensitization asthma rhinitis remains poorly studied adults aim aim study assess allergic sensitization pattern associates asthma rhinitis multimorbidity methods adults egea study extensive phenotypic characterization data available skin prick tests allergens total ige blood eosinophils included using questionnaires participants classified groups asymptomatic asthma rhinitis non allergic rhinitis alone allergic rhinitis alone asthma alone asthma non allergic rhinitis asthma allergic rhinitis mono polysensitization defined positive skin prick test one one allergen respectively results asymptomatic participants non allergic rhinitis alone mostly non sensitized around around polysensitized participants allergic rhinitis alone asthma alone asthma non allergic rhinitis non sensitized polysensitized participants asthma allergic rhinitis polysensitized level total ige followed similar trend allergic sensitization eosinophils increased asthma especially associated rhinitis nasal symptoms severe eczema common participants asthma allergic rhinitis groups conclusions allergic sensitization particularly polysensitization rates widely differ according asthma rhinitis status study emphasized importance taking account multimorbidity asthma rhinitis showed allergic sensitization dichotomic variable
study based earlier one containing proposed taxonomic classification reviewed updated according growth emergence practices period intrinsic level studied purpose nature activities rethought analysed relevance appropriateness adventure physical activities nature apan valid name identify extrinsic level identified apan currently significantly performed part population worldwide restructured completed taxonomic classification specific presence new emerging sector fire due increasing presence practices use internal combustion engine built table identifying selected apan practices drew table environmental impacts four pollutant classifications finally developed coordinate axis link degree sportisation groups practices asceticism hedonism variable previous study distinguished three major mediums air earth water groups groups groups respectively total structured groups clearly identified practices current study four mediums air earth water fire groups groups groups groups summary build groups distinguish practices
bone status impairment represents complication generalized forms epidermolysis bullosa however prevalence main determinants event localized forms remain poorly defined birmingham epidermolysis bullosa severity bebs score hydroxyvitamin levels strongly associated low bone mass suggesting vitamin may play potential beneficial role bone health longitudinal studies needed order confirm hypothesis bone status impairment represents complication generalized forms thus aimed estimate prevalence low bone mass examine mineralization differences various subtypes identify important determinants bone impairment children either generalized localized observational study children males mean age standard deviation years performed clinical history physical examination laboratory studies ray left hand wrist bone age dual energy ray absorptiometry scans lumbar spine obtained areal bone mineral density abmd scores bone mineral apparent density related bebs score areal bmd score mean range reduced patients whereas abmd score adjusted bone age low patients bebs score hydroxyvitamin serum levels important elements associated abmd respectively significant correlation abmd score area skin damage insulin like growth factor reactive protein sodium serum levels also found low abmd considered systemic complication primarily associated bebs score hydroxyvitamin levels therefore longitudinal evaluation bone status ongoing patients define whether vitamin supplementation would prevent least reduce bone status impairment
rapid changes cross polarization discrimination xpd band satellite radio wave signals caused thunderstorm events presented yearly statistics yearly variations discussed using polar cross polar signals received past years number thunderstorm events rapid changes xpd shows large yearly variations time scale five six years long term yearly variations may related periodic cycles equatorial climate nino nina tend bring weak strong convective activities respectively summertime weather japan
traditionally construction input integrated completion design stage projects inadequate construction input predesign stage front end planning fep process results fragility plans terms constructability paper reports research investigate construction input fep process research based three questionnaire surveys well complementary case studies questionnaires developed assess status fep process select areas require construction input respectively case studies selected pool projects collected data analyzed investigate barriers construction input results surveys case studies suggested lack well established interorganizational frameworks within project organizations loosely coupled network hinders effective construction input based results user friendly decision aid construction input assessment tool ciat developed framework facilitate frame benchmark required construction input fep process questionnaire sent industry experts test validate tool results research highlight importance construction input fep process identify application structured frameworks effective boundary objects established knowledge sharing firm level facilitating factors integrate construction input fep process include proposed tool tailored used industry systematically facilitate construction input fep process american society civil engineers
name based routing belongs routing category different address based routing usually adopted content oriented networks sharma koponen rajahalme thaler hwang gritter caesar carzaniga koponen hwang singla detti jain katsaros recently proposed named data networking ndn populates routers name based routing tables composed name prefixes corresponding next hop name based routing tables believed much larger size routing tables large amount name prefixes unbounded length prefix paper presents consert algorithm given arbitrary name based routing table input computes routing table minimal number prefixes keeping equivalent forwarding behavior optimal routing table also supports incremental update formulate consert algorithm prove optimality induction method evaluation results show consert reduce prefixes synthetic routing tables depending distribution next hops meanwhile improve lookup performance prior efforts usually focus compact data structures lookup algorithms reduce memory consumption expedite lookup speed routing table consert compresses routing table another perspective removes inherent redundancy routing table therefore consert orthogonal prior efforts thus combination consert prior compressing method would optimize memory consumption lookup speed routing table first adopt consert achieve optimal routing table afterwards apply namefilter wang two stage bloom filter method optimal table combination diminishes memory consumption routing table data structure roughly increases lookup throughput around simultaneously joint method outperforms individual method terms memory savings absolute lookup throughout increase elsevier rights reserved
paper potential risk undesirable events occurring tunneling application shield tunnel boring machine tbm method discussed along risk analysis systematically assess overall risk levels potential risks typical scenarios pertaining shield tbm tunnels investigated based previous case histories correspondence experts relevant risks undesirable events categorized four groups cutter related malfunction machine blockage hold mucking problems hinder transporting excavated materials segment defects fault tree set constructed grouping risk factors causes geological design construction management factors risk analysis performed adopting fault tree analysis fta analytic hierarchy process ahp consideration probability impact risks addition proposed method reliably validated comparison field observation thus indicates applicability risk management shield tbm tunneling elsevier ltd rights reserved
paper presents analytical methods calculate equivalent circuit parameters large scale brushless doubly fed machines bdfms magnetic wedges utilized closing stator open slots use magnetic wedges reduces magnetizing currents machine reflected values magnetizing inductances also increases leakage fluxes affecting value series inductances equivalent circuit though effects modeled numerical models proposed analytical methods particularly helpful optimizing machine design inverter rating reactive power management grid low voltage ride performance conventional analytical methods readily applied bdfm due complex magnetic field distribution paper presents analytical methods calculate magnetizing leakage inductances bdfm magnetic wedges used stator slots proposed methods assessed experimentally verified finite element models bdfm
water scarcity one major concerns people facing worldwide although liquid absolutely abundant globe availability poses much problems specifically region problems result one combination three basic situations declining water drought overabundance surface water floods degradation quality water pollution situations reflected scarcity good quality water arid regions particularly concerned areas groundwater contained aquifers usually perceived providence project groundwater exploration exploitation must preceded prior careful meticulous investigation order avoid early premature drying investigation likely predict future behaviour aquifers improve groundwater resources management beside fundamental properties hydraulic conductivity present paper addresses water sector semi arid region northern cameroon emphasizes importance porosity aquifer productivity consequently groundwater resources management porosity local aquifer determined using waxman smits model establishes reliable relationship apparent corrected formation factors taking clay effects consideration approach applied similar semi arid regions world
background medical students face variety stressors associated education promptly identified adequately dealt may bring several negative consequences terms mental health academic performance study examined psychometric properties korean version higher education stress inventory hesi methods reliability validity hesi examined large scale multi site survey involving medical students hesi beck depression inventory bdi questions regarding quality life qol self rated physical health sph administered results exploratory factor analysis hesi identified seven factors low commitment financial concerns teacher student relationship worries future profession non supportive climate workload dissatisfaction education subsequent confirmatory factor analysis supported factor model internal consistency hesi satisfactory cronbach convergent validity demonstrated positive association bdi known group validity supported hesi ability detect significant differences overall subscale scores hesi according different levels qol sph conclusions hesi psychometrically valid tool comprehensively assesses various relevant stressors related medical education evidence based stress management medical education empirically guided regular assessment stress using reliable valid measure warranted
aim study assess effectiveness acceptability photobiomodulation using mlsa laser therapy management acute radiation dermatitis compared two successive groups breast cancer patients undergoing identical radiotherapy regimens post lumpectomy groups received standard skin care second group received six additional sessions beam area starting fraction radiotherapy control group respectively clinical outcomes severity using radiation therapy oncology group rtog criteria radiotherapy induced skin reaction assessment scale risras dermatology specific quality life skindex start end radiotherapy secondary outcomes patients ratings skin care pleasantness soothing effect global satisfaction skin toxicity equivalent groups start significantly differed end radiotherapy aggravation control group versus rtog grade respectively found significant group differences respect quality life however risras subjective score decreased group implying decreased impact patients quality life finally patients ratings significantly higher standard care findings suggest might effective manage acute warrant research
soccer biggest sport world resulting large number injuries occurring game many soccer players today ready physically mentally return play aim study investigate injured players perception time sports injury occurred study conducted using qualitative approach eight soccer players four male four female aged years interviewed individually material analysed using manifest content analysis participants reported various psychological aspects affected positively negatively rehabilitation period individual factors included injured players reaction motivation fear situational factors coach team family physiotherapist also influenced participants conclusion several psychological factors affect young soccer players perception rehabilitation severe injury study found support team coach often lacking soccer player rehabilitation
soft morphing ray propulsor capable generating undulating motion pectoral fins designed fabricated propulsor used shape memory alloy actuation body made soft polymers determine effects undulation fins two models differed terms presence undulation fabricated using different polymer materials experimental models tested dynamometer measure compare thrust tendencies thrust measurements conducted various fin beat frequencies using experimental data concept optimized standalone version ray robot suggested prototype fabricated fabricated robot able swim fast body length per second efficient smart material based ray like underwater robots
low bone mass leads fracture risk osteoporosis affects population one every two women age years genetics predicts half bone mass diet weight bearing exercise two lifestyle choices influence risk fracture nutrients structural constituents bone bone living tissue turns albeit slowly tissues obligatory loss minerals daily must replaced diet three servings dairy products daily recommended replace losses alternative sources nutrients come calcium fortified orange juice plant based beverages tofu provide many nutrients needed bone health supplements provide nutrients risk inadequate calcium vitamin
computer vision research first important step represent captured object mathematical transformed feature vector describing proper shape texture color information classification understand nature biodiversity together computer vision emerging ubiquitous mobile technologies used therefore paper novel low computational efficient accurate rotation scaletranslation invariant shape profile transform called angle view projection avp proposed leaf images captured via mobile devices transformed avp shape profile curve set four shapelets compacted using discrete cosine transform dct improve performance system also reduces energy consumption device algorithm tested five different types leaf datasets flavia dataset plant species leaves dataset swedish database intelligent computing laboratory leaf dataset diseased leaf dataset agent mobile device decides whether module needs offload server compute device experiments carried clearly indicates proposed system outperforms state art fast response time even low vision environment avp also outperforms methods tested incomplete leaves caused due physiological pathological phenomenon avp shape profile based mobile plant biometric system developed general applications society better understand nature helps botanical studies researches
objective study analyze knowledge elders regarding hiv aids sexual quotient genders social center town countryside minas gerais brazil descriptive transversal quantitative study involving elders belong social groups offered facility care elderly uai portuguese acronym town uberaba study following instruments used meem select minimum level cognition qhivi evaluate knowledge measure sexual quotient data analyzed statistical package social sciences spss version females represented participants stated partner questions regarding transmission needles syringes greatest number right answers however answered correctly question transmission mosquito bites elders know possible detect virus laboratory exams stated never used condom sexual intercourses regarding sexual quotient female elders stated bad null sex life male stated inactive sex lives campaigns targeted population necessary well increase awareness health professionals since would make possible recognize sexuality elder risks inherent
goal research develop psychometrically evaluate portuguese version revised peer experience questionnaire assesses aggression victimization prosocial behavior victimization aggression among adolescents school settings growing problem yet fully understood properly evaluated particularly portugal sample adolescents recruited female ages varying years old attending middle high school confirmatory factor analysis confirms measurement model instrument bully victim versions evaluating overt relational reputational aggression victimization providing receiving prosocial behavior respectively measurement model invariant across schooling gender showed adequate internal consistency indicators presented evidence construct validity relation variables descriptive analyses indicate boys aggressive overt relational forms victimized overt aggression whereas girls aggressive victimized relationally form aggression victimization boys girls revealed higher values engaging receiving prosocial behavior results suggest instrument reliable valid structurally sound measure aggression victimization prosocial behavior portuguese school based community sample hence use may assist researchers gaining better understanding adolescent aggression victimization
report prenatal detection novo unbalanced complex chromosomal rearrangement ccr fetus growth delay bilateral cataracts standard karyotype fish analyses amniotic fluid revealed complex novo translocation resulting karyotype cgh array showed significant deletion distance breakpoint encompassed hmga gene occurred novo although microdeletions associated growth delay several reports literature present smallest deletion prenatally detected detail clinical description fetus correlation cataracts complex genotype puzzling among genes disrupted breakpoint grip associated abnormal eye development mice including lens degeneration interestingly hmga expressed mouse developing lens expression decreased lens elderly humans correlated severity lens opacity report refine link hmga loss function growth delay prenatal development also discuss correlation cataracts genotype unbalanced ccr case unexpected complexity elsevier masson sas rights reserved
background worldwide several bodies produce renal guidelines potentially leading duplication effort topics may remain uncovered collaborative work plan could improve efficiency impact requires common approved methodology aim study identify organizational methodological similarities differences among seven major renal guideline bodies identify methodological barriers collaborative effort methods electronic item survey questions based institute medicine standards guidelines completed representatives seven major organizations producing renal guidelines canadian society nephrology csn european renal best practice erbp kidney disease improving global outcome kdigo kidney health australia caring australians renal insufficiency kha cari kidney disease outcome quality initiative kdoqi sociedad latino americano nefrologia ehipertension slanh united kingdom renal association results five seven groups conduct systematic searches evidence two include detailed critical appraisal use grade framework five public review guideline draft guidelines updated new evidence comes specified time frame passed commentaries position statements guidelines published groups produced five adapte framework agreeii used funding parent organizations directly industry none allow funders influence topic selection guideline content budgets develop full guideline vary guideline development groups vary size persons three explicitly seek patient perspectives example involving patients scoping process four incorporate health economic considerations provide training methodology guideline development groups six make methods public try avoid overlapping topics already planned published others common conflict interest policy conclusions overall considerable commonality methods approaches renal guideline development different organizations although procedural differences remain financial human resource costs guideline production high collaborative approach required maximize impact develop sustainable work plan coming consensus methods procedures first step appears feasible
self resemblance found context dependent effect expressing preferences faces whereas dissimilarity preference mate choice animals often explained evolutionary adaptation increase heterozygosity offspring self resemblance also favored humans reflecting preference kinship cues performed two studies using transformations facial photographs manipulate levels resemblance rater examine influence self resemblance single coupled individuals raters assessed facial attractiveness sex sex photographs according short term long term relationship contexts found preference dissimilarity sex sex faces single individuals effect self resemblance coupled raters effect sex participant short term long term attractiveness rating observed results support evolutionary interpretation dissimilarity sex faces preferred uncoupled individuals adaptive mechanism avoid inbreeding contrast lower dissimilarity preference sex faces coupled individuals may reflect suppressed attention attractiveness cues potential alternative partners relationship maintenance mechanism substitution attention cues kinship psychological similarity connected greater likelihood prosocial behavior acquisition persons
paper presents several new cmos translinear topologies suitable static dynamic analogue signal processing realized using floating gate mosfets possibility controlling apparent threshold voltage mosfets multiple control gates offers extra degree freedom successfully exploited design low voltage circuits also multiple floating gates effectively used simplify circuit configurations topologies implement one two variable objective functions polynomial approximated continued products decomposed objective functions must contain time frequency variables proposed topologies analyzed standard cmos process via simulations different objective functions
order improve energy efficiency computation intensive workloads cloud radio access network ran virtualized hardware accelerators proposed paper ran architecture base stations running virtual machines virtualization mechanism makes feel like owning exclusively actually bss sharing tackle problem efficiently sharing multiple bss cloud platform scheduling algorithm pipelined first come first service fcfs proposed paper named fcfs fcfs sets two queues tasks aiming fully utilize pipelining model design multiple virtual bss access simultaneously efficiently evaluate performance fcfs use accelerate turbo decoding lte physical layer lte phy implement scheduling algorithm virtuaized xen paravirtualization environment experimental results indicate four virtual bss running lte phy bandwidth supported well fcfs based evaluation system performance improved compared fcfs scheduling algorithm
study objectiveto evaluate odds achieving viral suppression human immunodeficiency virus hiv patients using antiretroviral therapy single tablet regimen str multiple tablet regimen mtr designretrospective cohort study data sourcessouth carolina medicaid medical pharmacy paid claims data obtained south carolina revenue fiscal affairs office laboratory data obtained south carolina department health environmental control patientsa total patients dispensed complete str patients mtr patients regimen lasting least days january december measurements main resultsthe analysis examined adherence levels regimen type odds viral load suppression regimen adherence levels less compared gold standard adherence hiv greater patients followed index date earliest date regimen discontinuation treatment switch end study period last date eligibility death differences outcomes evaluated wilcoxon rank sum statistical tests multivariate regression models controlling covariates str regimens find compared greater adherence statistical difference odds viral suppression adherence levels greater equal however adherence levels greater equal associated greater odds viral suppression compared less str adherence odds ratio dunnett confidence interval mtr regimens statistical difference odds viral suppression adherence level compared greater adherence dunnett however greater adherence greater odds viral suppression compared mtr adherence levels addition difference found odds viral suppression str mtr adherence levels conclusionscompared greater adherence str regimens achieve viral suppression adherence levels greater whereas mtr regimens require adherence levels greater achieve viral suppression south carolina medicaid patients hiv aids
experiments pregnant rats demonstrated absence damaging effect afobazole administered antenatal period organogenesis fetuses afobazole dose given pregnant rats gestation days reduced pre post implantation fetal mortality improved fertility day old embryos developmental abnormalities differ controls craniocaudal size body weight skeleton ossification afobazole dose reduced pre post implantation fetal mortality effect fertility congenital malformations found fetuses characterized lower craniocaudal size body weight number ossification foci sternum spine
paper reviews peer reviewed research leadership africa published review dual purpose one hand provides scholars entry point relatively large body historical literature means descriptive diachronic analysis literature hand also applies synchronic analysis concludes four interpretative statements scholarship leadership africa statements scholarship leadership africa changed change lopsided female scholars increasing work different themes male scholars iii legitimacy remains key issue continues evolve authenticity become key issue closely related reclaiming african values
free radical toxicity due poorly maintained cellular redox levels crucial events associated pathogenesis guillain barre syndrome gbs patients uric acid albumin correlate oxidative stress degree aimed evaluate relationship gbs serum levels albumin present study serum levels albumin determined individuals including patients gbs healthy controls found serum levels albumin patients gbs significantly lower group besides similar phenomenon observed male female subgroups estimated respectively additionally found statistic difference among subgroups gbs regarding albumin univariate analysis revealed high high albumin protective factors patients gbs odds ratio confidence interval respectively confirmed multivariable logistic regression analysis adjusting potential confounding factors respectively conclusion found patients gbs significantly low serum albumin levels moreover demonstrated high high albumin protective factors patients gbs
hypothyroidism common adverse event head neck radiotherapy human medicine uncommonly reported canine patients records dogs histologically cytologically confirmed thyroid carcinoma receiving definitive hypofractionated radiotherapy reviewed nine cases received fractions received fractions received fractions seventeen cases radiotherapy post operative setting ten cases developed hypothyroidism radiotherapy development hypothyroidism associated radiotherapy protocol used median time diagnosis hypothyroidism months range months hypothyroidism common side effect following radiotherapy thyroid carcinomas monitoring thyroid function following radiotherapy recommended specific risk factors identified
nitrobenzene widely used manufacturing different types products aromatic chemicals moreover highly toxic environmental pollutant compound therefore detection nitro aromatic compounds nacs gained attention field sensor article describes green reduction utilized preparation green reduced graphene oxide nickel tetraphenyl porphyrin grgo tpp nanocomposite modified electrode determination nitrobenzene grgo prepared environmentally friendly method using caffeic acid reducing agent moreover grgo tpp nanocomposite prepared via stacking interaction rgo tpp addition prepared material confirmed visible spectroscopy nuclear magnetic resonance spectroscopy nmr fourier transform infrared spectroscopy ftir structural morphology elemental composition prepared nanocomposite confirmed scanning electron microscope sem energy dispersive ray spectroscopy edx besides electrochemical studies prepared nanocomposite characterized dpv technique dpv studies displayed linearity response proposed sensor sensitivity limit detection lod furthermore grgo tpp nanocomposite modified electrode shows good selectivity towards detection addition real sample analysis exhibited appreciable recovery towards determination using various types water samples elsevier inc rights reserved
aim evaluate association using benzodiazepines bzds short long acting durations migraine occurrence methods migraine group comprised subjects older years newly diagnosed migraine comparison group comprised subjects without migraine bzds used subjects dichotomously defined short acting half life long acting substances logistic regression model used calculate odds ratio migraine associated bzd exposure diseases results adjusted migraine associated bzd exposure confidence interval either exposure short acting bzd alone using combining long acting bzd significant higher risks migraine adjusted adjusted respectively whereas long acting bzd use associated increase migraine meanwhile sleep disorders anxiety stroke strongly associated migraine adjusted respectively conclusions observed significant increase migraine occurrence subjects using short acting bzds either alone combination long acting ones
procedures around interviewing police officer shooting recently come increased scrutiny argue officers allowed view available video footage body cameras wait two three days stress interviewed viewing video first may increase accuracy details present footage may also cause forgetting distortion parts situation captured camera including officer perception construal situation additionally memory likely decay delay waiting period little support claim long stressing period improve accuracy compared immediate report though complex policy matter many considerations procedures may harm good comes preserving accurate helpful memory police officer
aim study investigate body mass index bmi anti citrullinated protein antibodies acpas status presence periodontitis igg igg antibodies porphyromonas gingivalis first degree relatives fdrs rheumatoid arthritis patients compare variables control group healthy individuals general population total fdr individuals healthy controls matched age gender included rheumatologic periodontal assessment performed presence acpas anti gingivalis antibodies evaluated groupwise comparisons analysed using mcnemar wilcoxon tests conditional logistic regression analysis performed establish associations bmi acpas periodontitis groups fdr group subjects female mean age years obesity observed fdrs controls respectively acpas found fdrs controls periodontitis diagnosed fdrs controls respectively among fdrs severe periodontitis associations fdr group related presence obesity acpas periodontitis regarding anti gingivalis antibodies smoking history differences found groups obesity acpas periodontitis diagnosis severity considered relevant conditions associated development fdrs
paper proposes stochastic evaluation method examining tree population states river cross section using integrated model monte carlo simulation integrated model consists four processes submodels tree population dynamics flow discharge stochasticity stream hydraulics channel geomorphology floodplain kako river japan examined test site currently well vegetated features many willows growing individual size overall population last several decades model used stochastically evaluate effects hydrologic geomorphologic changes tree population dynamics monte carlo simulation effects including magnitude flood impacts relative change floodplain level examined using simple scenarios flow regulation climate change channel form changes stochastic evaluation method revealed tradeoff point floodplain levels tendency fully vegetated state switches bare floodplain small impacts flood concluded results states tree population floodplain determined mutual interactions among flood impacts seedling recruitment tree growth channel geomorphology interactions make difficult obtain basic understanding tree population dynamics field study specific floodplain stochastic approach used paper could constitute effective method evaluating fundamental channel characteristics vegetated floodplain
introduction molecular assays detection accurate quantitation hepatitis virus hcv rna important identification management hepatitis furthermore hcv genotype assessed prior treatment initiation recently roche developed cobas hcv tests use cobas systems cobas system cobas hcv genotyping test use cobas system areas covered analytic clinical performance newly developed tests described according currently existing literature tests detection quantitation hcv rna shown sensitive linear correlate well established roche tests used routine diagnostic laboratory cobas hcv test shows good performance suitable identification hcv genotypes genotype subtypes clinical specimens individuals chronic hcv infection expert commentary new tests effective screening hepatitis infection management patients chronic hcv infection ensuring full hcv genotype coverage replace established roche tests within next years
background although hydroxyvitamin commonly used define vitamin status consensus cutoff levels vitamin deficiency insufficiency study aimed identify threshold maximally suppressed parathyroid hormone pth hong kong chinese population methods study included participants female hong kong osteoporosis study aged total measured three phase segmented regression used identify optimal break point pth results prevalence vitamin deficiency observed prevalence insufficient nmol deficient nmol vitamin levels study population using unadjusted three phase segmented regression estimated first second break point pth suppression nmol nmol whereas estimated first second break point nmol nmol adjusting factors affecting bone mineral metabolism addition relationship pth significantly differed sex age conclusion threshold point maximal suppression pth estimated study lower suggested threshold vitamin deficiency literature perhaps due race assay differences relationship vitamin pth changed sex age standardization methodology searching optimal break point desirable consensus cutoff points obtained elsevier inc rights reserved
usually induction machine closed slots rotor lower harmonics stator line currents open slots however induction machines closed rotor slots may suffer local saturation rotor slot bridges thus exhibit significant low order time harmonics stator currents phenomenon revealed theoretical analysis validated finite element analysis experiments study reference value induction machine design avoid low order current harmonics
far paucity data allergen component resolved diagnosis prevalence grass pollen allergen components china contrast western countries even country allergies grass pollen allergen components vast south inadequately described study aimed determine major sensitizing grass pollens guangzhou largest city guangdong province southern china included study patients allergic rhinitis without asthma healthy controls immunocap used examine serum samples sige bermuda timothy humulus scandens subjects tested positive examined sige bermuda antigen cyn timothy antigens phl ccd relationship grass pollen allergy specific antigen sensitization assessed result patients allergic rhinitis asthma positive bermuda sige timothy sige humulus scandens sige patients likely sensitized compared controls bermuda sige positive patients cyn positive timothy sige positive timothy positive patients positive phl positive phl tested positive phl patients high bermuda sige levels likely positive grasses bermuda grass positive patients ccd sige also positive sensitization phl significantly correlated ccd summary found southern chinese patients allergic rhinitis asthma tested positive bermuda timothy humulus scandens ige high bermuda sige level may predict sensitization grasses correlations sensitization ccd grass pollen allergens suggested likelihood cross reactivity vitro inhibition assays required confirm relationship elsevier ltd rights reserved
novel increased group delay slope loop scheme proposed enhance time frequency resolution dispersive delay structure dds components microwave analog signal processing systems scheme signal output dds regenerated amplifier reinjected via nondispersive delay line toward input along loop pass across dds effective group delay slope system increased turns along loop time frequency resolution enhanced factor approach provides solution unpractical approach cascading dds units would lead excessively large device footprint unacceptably high insertion loss severe signal noise reduction proposed scheme implemented proof concept circuit using section pass network dds demonstrated experimentally frequency meter frequency discriminator possible improvements higher performance discussed
current study wind tunnel tests buffeting analyses conducted catwalk structure suspension bridge turbulent winds wind tunnel tests found reynolds number effects aerostatic coefficients negligible catwalk floor systems simple design formulas proposed estimate aerostatic coefficients catwalks various solidity ratios angles attack buffeting analysis results revealed tying catwalk erecting main cable may effective structural countermeasure reduce lateral displacements catwalk stay ropes fastening catwalk bridge tower also found effective alleviating lateral displacements
latest variants denial service attack like low rate denial service attack require packets launching attack result reducing number packets required traceback gained considerable importance packet marking schemes routers probabilistically mark packets therefore large number packets required victim reconstruct complete attack path paper introduce efficient data structure known wrap around counting bloom filter wcbf minimize required number packets wcbf maintains set cyclic counters decide particular mark needs sent victim faster traceback prove efficacy technique performing detailed theoretical analysis confirm using extensive experimental results case probabilistic packet marking proposed scheme reduces number packets times likewise case deterministic packet marking number packets required reduced times also show wcbf incorporated different variants probabilistic packet marking deterministic packet marking obtain effective results finally highlight benefits wcbf traceback schemes like logging hybrid traceback copyright john wiley sons ltd
second order plus dead time model approximates many processes chemical metallurgical paint paper oil refineries petroleum industries pid controller commonly used control industrial process present analysis various pid controllers based skogestad internal model control principles different closed loop constants designed selected second order plus dead time model selected model approximated using different approximation techniques significant time response characteristics closed loop responses designed controllers compared analyzed set point tracking controller
aim longstanding debate long term effect intensive endurance training cardiac function usually echocardiography used global evaluation left ventricular right ventricular function dimensions recently speckle tracking strain provided analysis regional function thus intention study carefully evaluate cardiac function group former world class swimmers applying longitudinal strain circumferential strain analysis methods twelve athletes years former training group involved high intensity endurance training examined years end active swimming career echocardiography performed function analyzed based also evaluated measurements performed epicardium endocardium independently results mean endocardial epicardial endocardial epicardial endocardial mean value epicardial conclusion twenty five years cessation endurance training evidence deterioration function values strain measurements within normal ranges
background hemodiafiltration line endogenous reinfusion hfr extracorporeal dialytic method combines diffusion convection adsorption hfr supra hfr second generation system increased convective permeability adsorption capability previous studies suggested hfr reduces oxidative stress compared standard haemodialysis principal aim present study compare antioxidant vitamins behavior oxidative status hemodialysis patients treated hfr hfr methods study designed multicenter randomized crossover trial forty one patients recruited dialysis centers month washout stabilization period line hemodiafiltration hdf patient randomized sequence treatments hfr followed hfr viceversa treatment applied months plasma levels advanced oxidation protein products total antioxidant status vitamins ligands retinol binding protein total lipids measured baseline end treatment period results results show higher convective permeability hfr respect hfr produce additional beneficial effects patients oxidative status slight decrease vitamin retinol binding protein difference registered long term however compared hdf infusive techniques allowed reduce intradialytic loss vitamin long term improve patients oxidative status increase retinol binding protein plasma values significant differences found vitamin concentration pre post cartridge neither hfr hfr showing sorbent resin adsorb vitamin conclusion hfr hfr almost equivalent term impact antioxidant vitamins oxidative status hemodialysis patients nonetheless compared hdf treatments produced sensible sparing vitamin may represent new approach reducing oxidative stress related complications dialysis patients longterm effects infusive treatments patients cardiovascular morbidity mortality need evaluated
background alpha synuclein asn principal component lewy pathology strongly influences pathogenesis parkinson disease increased level asn protein causes microglial response reactive microglial cells may actively participate damaging dopaminergic neurons data suggests asn accumulation astrocytes might damage cells substantia nigra pars compacta promotes degeneration dopaminergic neurons examined potential role recombinant asn monomers major pathogenic factor causing inflammatory response central nervous system methods mice bilaterally infused human asn monomers striatum single treatment structure per brain decapitated weeks post injection changes level inflammatory factors evaluated using real time pcr western blot method analysis morphological changes glial cells performed immunohistochemical staining results observed strong activation microglia cells increased expression striatal interleukin alpha tumor necrosis factor alpha interferon gamma asn injection noticed increase striatal glial fibrillary acidic protein mrna level weeks asn injection injection asn led increase striatal transforming growth factor beta mrna level influence striatal glial fibrillary acidic protein mrna level conclusion results suggest microglia activation supressing astrocytes play crucial role asn related dopaminergic neurotoxicity institute pharmacology polish academy sciences published elsevier rights reserved
microwave interferometry recently emerged novel suitable noncontact technology monitor vibrations displacements various engineering structures paper presents method evaluate possibility microwave interferometry long term periodic measurement dynamic deflection long span railway bridge dynamic loads train passing bridge without auxiliary equipment order eliminate refraction influences transmitted electromagnetic waves different monitoring atmospheric environment essen froome empirical formula adopted calculate atmospheric refractive index make atmospheric parameters correction apc improve measurement accuracy first experiment carried two corner cube reflectors fixed tripods flat playground continuous stationary monitoring carried image interferometric survey ibis validate apc method resulting rms errors reduce apc highlight reliability accuracy apc application microwave interferometry second long span beijing tianjin intercity railway monitored twice interval months proposed methods results show monitored long span railway bridge stable condition microwave interferometry maybe alternative technique long term periodic measurement dynamic deflection railway bridges
due limited resources actors third party auditing vital significance ambient intelligence systems ensures integrity data stored information manager however current public key based third party auditing schemes costly simple mac based third party auditing schemes fulfill two security requirements namely privacy preserving integrity tpa requirements taking security efficiency account paper proposes novel simple mac based third party auditing scheme much efficient current public key based schemes still fulfills two security requirements therefore feasible deployed ambient intelligence systems
numerical analysis presented cell adhesion capillaries whose diameter comparable smaller cell contrast large number previous efforts leukocyte tumor cell rolling much still unknown cell motion capillaries solid fluid mechanics cell flow coupled slip bond model ligand receptor interactions size capillary reduced cell always transitioned bullet like motion consequent decrease velocity cell state diagram obtained various values capillary diameter receptor density found bullet motion enables firm adhesion cell capillary wall even weak ligand receptor binding also quantified effects various parameters including dissociation rate constant spring constant reactive compliance characteristics cell motion results suggest even interaction selectin glycoprotein ligand psgl selectin mainly responsible leukocyte rolling cell able show firm adhesion small capillary findings may help understanding phenomena leukocyte plugging cancer metastasis
study applies integrated moral obligation model examine role environmental cultural values beliefs activation landowner conservation norms data study collected self administered survey riparian landowners two minnesota watersheds sand creek vermillion river watersheds study findings suggest collectivistic biospheric altruistic values form bases activation personal norms beliefs local responsibility ability act influence personal norms protect water resources findings suggest landowners personal norms water conservation likely activated conservation strategies appeal biospheric altruistic collectivistic values emphasize adverse consequences water pollution highlight water resource protection local responsibility provide resources needed protect water resources
multiple sclerosis outcome assessments consortium msoac includes representatives advocacy organizations food drug administration fda european medicines agency ema national institute neurological disorders stroke ninds academic institutions industry partners along persons living multiple sclerosis one msoac goals acceptance qualification regulators performance outcomes highly reliable valid practical cost effective meaningful article addresses history application psychometric properties one msoac metric ambulation walking namely timed foot walk tfw tfw strong reliability brief long periods time across large range disability levels outcome walking speed tfw obvious real world relevance correlated strongly measures walking lower extremity function tfw responsive capturing intervention effects pharmacological rehabilitation trials established value capturing clinically meaningful change ambulation directions future research involve validating clinically meaningful improvements tfw well determining whether change clinically meaningful across disability spectrum researchers might consider synchronizing accelerometers motion sensors tfw capturing walking speed everyday life patient real environment
article presents new technological solution improve safety embankment bases taliks construction periods use geotextile sleeved sand columns geogrids low temperature permafrost investigated correlations mechanical temperature processes depth base improvement method calculated
functional dependencies powerful concept data organization proven useful relational databases reducing data redundancy little work however done far using context data cubes present paper propose characterize parts data cube materialized help present underlying data purpose consider two applications choose best cuboids data cube materialize order guarantee fixed performance query evaluation choose best tuples hence partial cuboids order reduce size data cube without loosing information cases turn fundamental characterizing solutions problems
apple leaf disease one main factors constrain apple production quality takes long time detect diseases using traditional diagnostic approach thus farmers often miss best time prevent treat diseases apple leaf disease recognition based leaf image essential research topic field computer vision key task find effective way represent diseased leaf images research based image processing techniques pattern recognition methods apple leaf disease recognition method proposed color transformation structure input rgb red green blue image designed firstly rgb model converted hsi hue saturation intensity yuv gray models background removed based specific threshold value disease spot image segmented region growing algorithm rga thirty eight classifying features color texture shape extracted spot image reduce dimensionality feature space improve accuracy apple leaf disease identification valuable features selected combining genetic algorithm correlation based feature selection cfs finally diseases recognized svm classifier proposed method selected feature subset globally optimum experimental results correct identification rate apple diseased leaf image database contains disease images kinds apple leaf diseases powdery mildew mosaic rust demonstrate proposed method feasible effective
aimsto identify different types models used economic evaluations smoking cessation analyse quality included models examining attributes ascertain transferability new context methodsa systematic review literature economic evaluation smoking cessation interventions published april identified via medline embase national health service nhs economic evaluation database nhs eed health technology assessment hta checklist based quality included studies transferability scores based european network health economic evaluation databases euronheed criteria studies smoking cessation original research model based economic evaluation consider adult population high income country excluded findingsamong economic evaluations included review state transition markov model frequently used method quality adjusted life years qaly frequently used outcome measure life time horizon small number included studies eligible euronheed transferability checklist overall transferability scores ranged average score average score per section range relative transferability studies could established due limitation present euronheed method conclusionall existing economic evaluations smoking cessation lack one key study attributes necessary fully transferable new context
mobile cloud computing active research domain investigate ways achieving federation mobile computing cloud computing whereas ambient intelligence aims teach mobile devices behave smart environment narrowing gap people devices environment two domains behave backbone ubiquitous environment around everything connected sharing information resources mobile devices use cloud resources cope ever growing computing storage demands smart applications context provisioning cloud mobile connectivity give rise new interactions cloud infrastructure effectively manage context information however lot contextual information sensed captured mobile devices always clear whether makes sense upload raw sensed data cloud processed many resource performance trade offs exist federated deployment smart mobile applications paper present quality aware federated framework overcome challenges smart applications support development deployment applications opportunistically using cloud computing framework highlights aspects quality context qoc provisioning dynamic adaptability uncertain context authors published elsevier
aim study examine relations among missing discrepant data eating disorders examination questionnaire ede fairburn beglin individual demographic factors eating disorder symptoms data men women collected five independent studies examined descriptive statistics used detect quantity missing discrepant data well independent samples tests chi square analyses examine group differences participants without missing discrepant data results indicated significant differences data completeness participant race ethnicity severity eating disorder symptoms white participants likely provide complete survey responses asian american participants least likely provide complete survey responses participants incomplete surveys reported greater eating disorder symptoms behaviors compared complete surveys similarly discrepant responses behavioral items reported greater eating disorder symptoms behaviors compared congruent responses practical implications recommendations reducing addressing incomplete data ede discussed elsevier ltd rights reserved
purpose investigate levels oxysterols healthy control multiple sclerosis patients interdependence demographic clinical characteristics cholesterol biomarkers methods study included subjects relapsing remitting progressive complete lipid profile including total cholesterol high density lipoprotein cholesterol hdl low density lipoprotein cholesterol ldl apolipoproteins apo reactive protein crp hydroxycholesterol ketocholesterol obtained lipoprotein particle sizing proton nuclear magnetic resonance nmr available subjects results levels lower compared higher compared ldl apob associated higher levels oxysterols ldl associated higher levels apob associated increased levels oxysterols conclusion findings lower compared higher compared indicate oxysterol network disrupted
objective determine whether association latitude annual major depressive episode mde prevalence canada methods data national survey programs national population health survey canadian community health survey used providing data sets collected together including respondents assessed mde using versions composite international diagnostic interview short form version studies canadian adaptation world mental health version studies approximate latitude determined linkage postal code data data analyzed using logistic regression pooled across surveys using individual level meta analytic methods results models including latitude continuous variable statistically significant association observed prevalence increasing increasing latitude association persisted adjustment set known risk factors latitude gradient modest magnitude increase prevalence odds mde per degree latitude observed due sparse data gradient confidently generalized beyond major population centres tend occur less degrees latitude canada conclusion latitude gradient previously reported replicated gradient may implications planning services generation aetiological hypotheses however cross sectional analysis confirm aetiology could evaluate potential contributions variables light exposure weather patterns social determinants
large wind parks wps essential priority mainly non residential districts especially offshore wps areas valuable energy potential without legislation prohibits without causing disturbance nearby community could release enormous land uses culture recreation areas tourism etc aim paper present methodology sustainable siting offshore based legal limitations particular respect ecological economic resources using example island crete also considered visual acoustic aesthetic disturbance coastal area residents visitors integrate context one essential issues make region unique undersea relief makes difficult numerous large scale intervention areas strictly protected three steps followed exception unsuitable areas geological restrictions visual acoustical disturb safety course due environmental conditions evaluation environmental impacts birdlife special protection areas sites community importance iii assessment wind potential needs electricity regional unit chania western crete elsevier ltd rights reserved
paper presents documentation development method facilitate certification scientific computing software used safety analysis nuclear facilities study problems faced quality assurance certification activities case study performed legacy software used thermal analysis fuelpin nuclear reactor although errors uncovered code issues incompleteness inconsistency found documentation work proposes software documentation follow rational process includes software requirements specification following template reusable maintainable understandable develop design implementation paper suggests literate programming alternative traditional structured programming literate programming allows documenting numerical algorithms code together termed literate programmer manual manual developed explicit traceability software requirements specification traceability theory numerical algorithms implementation facilitates achieving completeness consistency well simplifies process verification associated certification copyright published elsevier korea llc behalf korean nuclear society
thematic case based studies used instructors enhance critical thinking knowledge holistic fashion well improve students cognitive metacognitive processes case based learning approaches long used teaching business law medicine yet see widespread use many engineering disciplines furthermore empirical research effectiveness case based learning within engineering still infancy herein describe use impact case based instruction implemented third year undergraduate bioprocess engineering course university waterloo overall objective study link key concepts related bioprocess engineering real world bioprocesses series tutorial modules research projects tied together common thematic case developed case focuses genetically engineered escherichia coli production biofuels specifically propanol intent provide students opportunity gain deeper understanding biological systems linking traditional fields bioprocessing emerging field synthetic biology also immersing students situations could encounter working industry results suggest majority students felt case engaging small group based problem solving exercises helped understanding design principles relevant bioprocess engineering
article presents novel approach model mechanical response smart polymeric materials cyclobutane based mechanophore named smart particle article embedded epoxy polymer matrix form self sensing smart material spring bead model developed based results molecular dynamics simulation nanoscale represent bond clusters smart polymer spring bead network model developed parametric studies mechanical equivalence optimization represent microstructure material statistical network model introduced capable bridging high accuracy molecular dynamics model nanoscale computationally efficient finite element model macroscale comparison experimental simulation results shows multiscale model capture global mechanical response local material properties
undesired adhesion biomass solid substrates submerged liquid environments biofouling causes enormous financial losses worldwide biofouling could prevented appropriate physicochemical surface modification well established environmentally friendly approach report artful quartz crystal microbalance qcm based method qualitative situ assessment anti fouling potential variety functional coatings purpose three groups mhz qcms coated diamond like carbon dlc fluorocarbon functionalized diamond like carbon ffdlc carbon soot immersed aqueous suspensions four biofoulants red polysiphonia green scenedesmus algae cells diatom navicula filamentous cyanobacteria oscillatoria analysis resonance frequency dynamic resistance fluctuations sensor group reveals qcms capable detecting differences thermodynamics cell adhesion settlement affinity biofoulants depending coatings physicochemical properties particular soot superhydrophobicity nanoscale surface topography completely prevent biofouling soot coated qcms show relatively unaltered sensor signal probing cycles findings excellent foundation incorporation diverse biofouling assays miniature portable sensor devices elsevier rights reserved
paper sets provide big picture guide major advances structural engineering design taken place last five decades rapid advances computer technology period spurred development structural calculations ranging simple strength materials approach finite element type structural analysis design recent years modern development scientific simulation visualisation structural problems years come paper concludes continually emerging nature structural engineering associated codes practice offers exciting career balancing idealisations scientific theory engineering reality employing latest computing technology
amyloid beta beta fibrils amorphous aggregates found brain patients alzheimer disease implicated etiology metal imbalance also among leading causes owing fact beta aggregation takes place synaptic cleft beta iii found abnormally high concentrations beta beta main components plaques found afflicted brains coordination iii ions beta peptides linked beta aggregation production reactive oxygen species two key events development pathology metal chelation proposed therapy basis might prevent beta aggregation work first examined formation beta beta aggregates presence metal ions iii detected fluorescence spectroscopy atomic force microscopy second studied ability two chelators ethylenediaminetetraacetic acid chloro iodo hydroxyquinoline clioquinol investigate effect availability metal ions interact beta thereby effect beta accumulation findings show iii promote aggregation beta beta also found clioquinol decreased significantly iron ion induced aggregation beta presence ions chelators also affected morphology beta aggregates
objective evaluate facial soft tissue changes use fixed functional appliances class division malocclusion cases using systematic review literature materials methods several electronic databases pubmed medline medline process non indexed citations cochrane database embase web sciences lilacs searched help senior health sciences librarian abstracts appeared fulfill initial selection criteria selected consensus original articles retrieved references also hand searched possible missing articles clinical trials assessing facial soft tissue changes use fixed functional appliances without surgical intervention syndromic characteristics considered comparable untreated control group required factor normal growth changes four articles using herbst one using jasper jumper fulfilled selection criteria individual analysis articles made methodological flaws identified results although fixed functional appliances produce significant statistical changes soft tissue profile magnitude changes may perceived clinically significant conclusions conclusions systematic review considered caution secondary level evidence found long term double blinded prospective randomized clinical trials needed three dimensional quantification soft tissue changes required overcome current limitations understanding soft tissue changes obtained use fixed functional appliances
traditional network architecture inflexible complex observation led paradigm shift toward software defined networks sdns network control level separated data link layer change became possible control plane transfer switching equipment software modules run dedicated server called controller network operating system network applications work controller methods presentation storage communication interfaces network topology elements available sdn controller users important aspects network operating systems operation key controller modules depends heavily internal representation network topology firewall routing modules cited examples modules paper considers methods used represent store network topology well communication interfaces corresponding modules floodlight controller alternative algorithm exchanging messages changes network topology controller network applications proposed developed algorithm makes possible issue notifications based subscription relevant events api module interacting applied programs sdn controller developed topology tracker module designed based algorithm api active mode module inform network applications changes network topology store compact representation interaction acceleration
sustainable design practices key component ensuring building civil infrastructure industry damage natural environment green buildings allied initiatives sectors built environment primary mover promoting sustainable design practices important dangerous inhibitor sustainable design practices however perception among key decision makers additional costs green sustainably designed buildings high therefore economically viable study tested perceptions compared results limited actual cost data found cost premium less half decision makers think recommendations made around development awareness programmes undergraduate postgraduate levels need highlight necessity developing accurate data related green building costs need establish incentives drive take sustainable design practices
colorectal cancer one common cancers world effective treatment therefore development new methods early diagnosis instantly required biological recognition probes synthetic receptor aptamer one candidate recognition layers detect important biomolecules work electrochemical aptasensor developed fabricating aptamer cell aptamer sandwich architecture sba aminopropyltriethoxysilane sba nanoparticles aunps modified graphite screen printed electrode gspe surface selective label free detection cancer cells based incubation thiolated aptamer cells electron transfer resistance redox couple increased considerably aptasensor surface results obtained cyclic voltammetry electrochemical impedance spectroscopy studies showed fabricated aptasensor specifically identify cells concentration ranges cells cells respectively detection limit cells applying thiol terminated aptamer recognition layer led sensor high affinity cancer cells compared control cancer cells ags cells vero cells cells skov cells therefore simple rapid label free inexpensive excellent sensitive selective electrochemical aptasensor based sandwich architecture developed detection cells
paper presents new modeling method based signal flow graph correlation matrix firstly according signal flow graph signal tree selected based signal tree signal branch node added finding independent loop loop incidence matrix correlation matrix determine relevance loop help seek loop gain moreover mathematical model figured using mason formula theoretical analysis experimental results show nodes increase method simpler meaning formula clearer comparison existing methods method obvious advantages calculation expression method makes model system accurate modeling process becomes faster convenient
background evidence linking maternal psychosocial stress pregnancy subsequent child atopic dermatitis growing definition diverse results inconsistent aimed analyze relationship stress using alternative measurements stress methods ulm spatz health study chronic stress symptoms anxiety depression assessed standardized self reported questionnaires mothers singletons following delivery ulm germany maternal hair cortisol concentrations hccs childbirth cumulative incidences parent reported child symptoms parent pediatrician reported diagnoses assessed age years overall dermatologic examinations performed children showing symptoms crude adjusted risk ratios arr confidence intervals estimated results maternal stress anxiety associated child symptoms trend arr highest lowest quarter chronic stress arr possible anxiety symptoms symptoms relationship found stress related constructs diagnoses could show consistent associations maternal hcc child however higher child evident families yet affected siblings given maternal depressive symptoms examined crude model conclusions stress measurements related constructs linked symptoms association diagnoses limited reason divergence still needs research
objective greater body mass index bmi body fat associated vasomotor symptoms vms thus weight loss may prevent vms analyzed whether concurrent bmi waist circumference changes weight waist circumference predicted incident vms whether relations differed menopause stage race ethnicity methods data follow visits participants study women health across nation reported vms baseline modeled time first symptomatic visit relation concurrent bmi waist circumference change weight waist circumference early late menopause using discrete survival analyses adjusting covariates results greater concurrent bmi waist circumference significantly related greater frequent last incident vms early menopause lower vms risk late menopause percentage weight change since baseline since prior visit unrelated incident vms either menopause stage percentage weight change since baseline significant shallow shaped association incident frequent vms early menopause shallow inverse shape late menopause significant interaction menopause stage race ethnicity recent weight change unassociated incident vms either menopause stage results similar waist change conclusions concurrent bmi waist circumference positively related incident vms early menopause negatively related late menopause maintaining healthy weight early menopause may help prevent vms
blood cell production bone homeostasis physically interlinked systems exhibit active cross talk examined bone health affected patients hematopoietic disorders due abnormal proliferation bone marrow cells electronic databases medline embase pubmed biosis previews web science cochrane searched studies presenting numerical values trabecular bone volume bone mineral density control patients hematopoietic disorders identified studies beta thalassemia sickle cell anemia polycythemia vera essential thrombocythemia chronic myelogenous leukemia myelofibrosis multiple myeloma studies systemic mastocytosis lymphocytic leukemia hemochromatosis effect disease state bone density significant negative beta thalassemia confidence interval sickle cell anemia chronic myelogenous leukemia mastocytosis lymphoblastic leukemia multiple myeloma hemochromatosis changes negative significant polycythemia vera essential thrombocythemia myelofibrosis disease state associated increased bone density bone density change significantly negatively correlated level ferritin bone marrow cellularity hemoglobin erythropoietin thus independent hematopoietic lineage abnormal proliferation bone marrow cells appears associated bone loss iron metabolism may independently contribute bone homeostasis american society bone mineral research
first commercial wave farm came online portugal types renewable energy electricity obtained waves drawback intermittency knowing hours ahead much energy waves hold contribute better management electricity grid work three types statistical models used create forecasts zonal meridional components wave energy flux wef levels three directional buoys located coast bay biscay model performance compared confidence level simplest prediction persistence levels along forecasts provided physics based wave modeling wam wave model nearest grid point results indicate forecasting horizons roughly ahead statistical models built random forests rfs outperform rest including wam persistence
context autologous adult neural cell ecosystem ance transplantation study four intact adult female macaque monkeys underwent unilateral biopsy dorsolateral prefrontal cortex dlpfc provide cellular material needed obtain ance monkeys previously trained perform quantitative motor manual dexterity tasks namely modified brinkman board task reach grasp drawer task aim present study extend preliminary data role prefrontal cortex motor habit test hypothesis dlpfc contributes predict grip force required precise level force generated known beforehand expected small dlpfc biopsy neither motor performance score spatiotemporal motor sequences affected modified brinkman board task whereas significant changes mainly decreases maximal grip force force applied drawer knob observed reach grasp drawer task present data macaque monkey related prediction grip force well line previous fmri data reported human subjects moreover ance transplantation strategy case stroke parkinson disease based biopsy dlpfc generate unwanted motor consequences least far motor habit motor performance concerned context sequential grasping small objects require development significant force levels
use virtual surgery patient specific saw drill guides custom made osteosynthesis plates rapidly spreading deformity surgery orthognathic surgery commercially available systems using computer aided design computer aided manufacture cad cam wafers produce patient specific saw guides however plate systems provided still conventional stock mini plates individually designed pre bending according stereolithographic model patient custom made three dimensional printed implants earlier demonstrated ideal solution deformity surgery reconstruction complex posttraumatic cases study report novel use patient specific saw drill guides combined patient specific titanium alloy implants fixation system maxillary movement fort bimaxillary osteotomies implants individually designed patient follow anatomical structures provide exact positioning stability repositioned maxilla european association cranio maxillo facial surgery published elsevier ltd rights reserved
paper stochastic optimal strategy unknown linear discrete time system quadratic zero sum games input output form communication imperfections network induced delays packet losses otherwise referred networked control system ncs zero sum games relating optimal control problem solved forward time manner first linear discrete time zero sum state space representation transformed linear ncs state space form incorporating random delays packet losses input output form subsequently stochastic optimal approach referred adaptive dynamic programming adp introduced estimates cost value function solve infinite horizon optimal regulation unknown linear ncs quadratic zero sum games presence communication imperfections optimal control worst case disturbance inputs derived based estimated value function absence state measurements update law tuning unknown parameters value function estimator derived lyapunov theory used show signals asymptotically stable estimated control disturbance signals converge optimal control worst case disturbances respectively simulation results included verify theoretical claims
one main complications caused diabetes mellitus development diabetic foot turn lead ulcerations ulceration risks linked increase plantar temperatures recent approaches analyze thermal changes approaches try identify spatial patterns temperature could characteristic diabetic group however difficult task since thermal patterns wide variations resulting complex classification moreover measurement contralateral plantar temperatures important determine whether abnormal difference provides information thermal changes asymmetric absence ulceration amputation therefore work proposed quantitative index measuring thermal change plantar region participants diagnosed diabetes mellitus regards reliable reference control regards contralateral foot usual also classification thermal changes based quantitative index proposed classification demonstrate wide diversity spatial distributions diabetic foot also demonstrate possible identify common characteristics automatic process based analysis plantar angiosomes image processing presented quantify thermal changes provide valuable information medical expert elsevier rights reserved
pragmatics historically played relatively peripheral role language evolution research profound mistake describe pragmatic perspective inform language evolution fundamental way making clear natural objects study hence aims field
today power systems become prone cyber attacks due high integration information technologies paper demonstrate outages lines masked injecting false data set measurements success topology attack guaranteed making injected false data obeys kirchhoff current law kirchhoff voltage law avoid detected bad data detection program state estimation residual line outage detection increased line outage detected phasor measurement unit data bilevel optimization problem set determine optimal attack vector maximize residual outaged line ieee bus bus systems used demonstrate masking scheme
paper presents precision full wave rectifier low level signal operational conveyor current mirrors operational conveyor circuit topology based current steering output stage also described analyzed current mode full wave rectifier realized four unity gain current mirrors three current sources pspice program used verify proposed design operational conveyor precision full wave rectifier results simulation presented compared simulation results realization published
background chest compressions core element cardio pulmonary resuscitation despite periodic training real life chest compressions reported overly shallow fast likely affecting patient outcomes investigated effect brief crew resource management crm training program correction rate improperly executed chest compressions simulated cardiac arrest scenario methods final year medical students randomised receive min computer based crm control training ethics acting team leaders subjects performed resuscitation simulated cardiac arrest scenario training team members performed standardised overly shallow fast chest compressions analysed often team leader recognised corrected improper chest compressions well communication resuscitation quality results crm training team leaders corrected improper chest compressions significantly often compared undergoing control training consequently four students trained number needed treat one improved chest compression scenario communication quality assessed leader behavior description questionnaire significantly increased intervention group mean compared control group conclusion computer based min crm training improved recognition ineffective chest compressions furthermore communication quality increased guideline adherent chest compressions linked improved patient outcomes crm training might represent brief affordable approach increase chest compression quality potentially improve patient outcomes
experiments younger older adults witnessed simulated robbery received misleading information event interviewed cognitive interview memory robbery experiments older adults disproportionately confident younger adults accuracy incorrect information recalled accuracy correct information critically age related increase high confidence errors occurred even comparison younger adults matched older adults overall amount accuracy information remembered robbery addition experiment showed retrieval warnings disregard misinformation effective older adults compared younger adults reducing reporting misleading information finally experiments showed across multiple retrieval stages cognitive interview final retrieval stage roughly half effective older adults relative younger adults eliciting previously unreported information results indicate investigators much less gain older adults younger adults repeated inquiries session witnessed event
background present study aims assess psychosomatic physical responses multi component stress management program use cam approaches among teaching professionals hong kong method random controlled trial rct used compare group cam group interventions administered week eight consecutive weeks self administered questionnaire including perceived stress scale pss frequency psychosomatic symptoms measured baseline immediate program weeks program physical parameters measured results reduction pss observed group cam group yielded reductions pss significant interactions observed frequency psychosomatic symptoms physical parameters however significant downward time trend observed larger percentage changes physical responses shown cam group group conclusion clinical evidence cam program demonstrated current study approaches easy self implemented cam technique might serve alternative choice self administered stress management replace additional time needed professional follow contacts might improve physical responses handgrip strength resting heart rate associated better psychosomatic health better occupational stress management elsevier ltd rights reserved
article discusses filtering prediction simulation univariate multivariate noncausal processes closed form functional estimator predictive density noncausal mixed processes introduced provides prediction intervals finite horizon state space representation noncausal mixed multivariate vector autoregressive process derived two ways partial fraction decomposition real jordan canonical form recursive bhhh algorithm maximization approximate log likelihood function proposed calculates filtered values unobserved causal noncausal components process new methods illustrated simulation study involving univariate noncausal process infinite variance
continuous monitoring environmental parameters provides farmers useful information improve quality productivity crops grown greenhouses objective study develop greenhouse environment measurement system using low cost microcontroller open source software greenhouse environment parameters measured air temperature relative humidity carbon dioxide concentration ranges temperature relative humidity concentration degrees ppm respectively graphic lcd display used real time monitoring greenhouse environments arduino uno consisted usb interface communicating computer analog inputs digital input output pins temperature relative humidity sensor connected digital pins sensor connected digital pins lcd connected digital pin sketches programmed arduino software ide measurement system including arduino board sensors accessories developed totaling data environmental parameters venlo type greenhouse obtained using system without problems expect low cost microcontroller using open source software used monitoring environments plastic greenhouses korea
neural circuit solve system simultaneous linear equations presented circuit employs non linear feedback achieve transcendental energy function ensures fast convergence exact solution enjoying reduction hardware complexity existing schemes new building block analog signal processing digitally controlled differential voltage current conveyor dvcc introduced utilized non linear synaptic interconnections neurons proof energy function given shown gradient network converges exactly solution system equations pspice simulation results presented linear systems equations various sizes found close agreement algebraic solution use cmos dvccs operational amplifiers facilitates monolithic integration
structural modifications pregnenolone described via introduction heterocyclic moieties position limiting acyl group novel heterocyclic analogues pregnenolone synthesized using friedlander claisen schmidt reactions synthesized compounds evaluated osteogenic activity among synthesized derivatives four compounds showed significantly increased alp activity among four active compounds novel compound shown significant bone matrix mineralization mrna expressions osteogenic marker genes bmp runx ocn concentration elsevier ltd rights reserved
section based gis technology spatial database technology computer programming technology based transformation villages city management system gis developed set data management query query attribute query spatial query condition thematic map making drawing generation functions one gis system provide data support technical services reconstruction planning city villages
solar flare occurred october accompanied multi wavelength emissions high flux relativistic particles observed present analytic results trace soho rhessi ace goes hard ray integral satellite radio onderejov radio telescope neutron monitor data found inferred magnetic reconnection electric field correlates well hard ray gamma ray neutron emission sun thus flare magnetic reconnection probably makes crucial contribution prompt relativistic particles could detected since neutrons emitted minutes injection protons electrons propose magnetic field evolution configuration explain delay exclude effect cme driven shock probably plays important role delayed gradual phase solar energetic particles
use thresher machines threshing rice plants helped farmers improving agricultural productivity however thresher machine design currently available fairly concerned working position posture farmers using working position modeled farmers operating thresher machine tent cause injury dimensions engine body farmers conform rula method one methods could analyze work postures results data collection process using rula method clear measures taken thresher machines used available promptly modified order avoid musculoskeletal problem improvements could undertaken avoid musculoskeletal problem farmers used thresher machine redesigning thresher machine based farmers working posture one ways adjusting dimensions farmers body dimensions machine addition use adjustable concept design could probably assist farmers adjust working position machinery used
testosterone key hormone pathology metabolic diseases obesity low testosterone levels associated increased fat mass particularly central adiposity reduced lean mass males morphological features linked metabolic dysfunction testosterone deficiency associated energy imbalance impaired glucose control reduced insulin sensitivity dyslipidaemia bidirectional relationship testosterone obesity underpins association indicated hypogonadal obesity cycle evidence weight loss lead increased testosterone levels androgenic effects enzymatic pathways fatty acid metabolism glucose control energy utilization apparent often tissue specific differential effects noted different regional fat depots muscle liver potentially explain mechanisms testosterone action testosterone replacement therapy demonstrates beneficial effects measures obesity partially explained direct metabolic actions adipose muscle also potentially increasing motivation vigour energy allowing obese individuals engage active lifestyles degree beneficial effects may dependent treatment modality longer term administration often achieving greater improvements testosterone replacement may therefore potentially effective adjunctive treatment weight management obese men concomitant hypogonadism
female alcohol consumption long judged harshly male behaviour nature scholars shown traditional mass media contribute strengthening stereotypes hypothesis present study new media especially web environments provide room rewriting gender roles relation alcohol test hypothesis videos retrieved youtube using list italian keywords relating drunkenness frequently viewed clips analysed multilayer visual ethnography method found representations drinking practices youtube seem reflect conventional double standard female drinking mainly interpreted sign sexual willingness strongly stigmatised cases moreover women actively contributed creating sexual meaning video protagonists commenters analysed materials seem show even user generated content medium youtube old gender stereotypes drinking fail deconstructed conversely images discourses analysed reinforce stereotypes reproducing messages conveyed mainstream media even explicit risky manner
purpose brief research report presents findings national household survey number percentage parents mental illness methods using combined annual data national survey drug use health parents defined children household birth years prediction models developed earlier clinical study using national survey drug use health subsample used estimate serious mental illness smi results total million parents smi past year million parents mental illness past year mental illness common among mothers fathers least common among asians compared races smi less prevalent parents aged years older compared younger age groups conclusions burden mental illness parents high united states especially among mothers physicians treat parents routinely screen mental illness discuss implications parenting elsevier inc rights reserved
one important problems stealth technology evaluate infrared radiation level received sensors fighters detected article presents synthetic method calculating emitted aircraft skin reckoning aerodynamic heating hot engine casing main heat sources exposed aircraft skin numerical model skin temperature distribution established computational fluid dynamics cfd technique based infrared signature model solving complex geometry structure fighter proposed reverse monte carlo rmc method finally way determining intensity aircraft skin aircraft components emit identified cooling effects main aircraft components intensity investigated found reduction skin temperature head vertical stabilizers wings could lead decline intensity aircraft skin front view broadside aircraft drops intensity could attain results provide useful reference designing stealthy aircraft
objective paper formulate validate accurate mpm approach numerical simulation large displacement membranes containing soil proposed approach membrane discretised surface mesh allows accurate simulation membrane stresses membrane free move three dimensional grid continuum consisting tetrahedral elements approach applied model geocontainer released split barge taking account frictional contact geotextile barge slip contact assumed geotextile soil inside effect geocontainer interaction investigated dropping second container copyright john wiley sons ltd
solar energy cascade utilization system using concentrated solar power developed response growing demand renewable energy distributed power generation however investigations geometric parameters cavity receiver performed dish stirling system present research field study proposes design optimization method solar cavity receiver capability achieving high operating temperatures developing thermal model cavity geometry results study provide prediction real situation sensitivity analysis cavity receiver design designed cylindrical receiver insulation consists enclosed bottom back aperture front helical pipe inside aperture diameter inner diameter length cavity three critical geometric parameters cavity receiver influence three parameters heat losses thermal efficiency analyzed paper elsevier ltd rights reserved
background general obesity abdominal obesity established risk factor gastroesophageal reflux disease gerd however influence weight waist change improvement gerd unclear aim investigate weight loss waist reduction improves gerd symptoms esophagitis methods retrospective longitudinal study subjects underwent gastroscopy health checkup reported gerd symptoms repeated checkup conducted improvement gerd symptoms esophagitis according weight loss body mass index bmi waist reduction baseline bmi waist circumference categories assessed using logistic regression key results weight loss waist reduction associated improvement gerd symptoms subjects general abdominal obesity among subjects general obesity bmi decreased bmi adjusted odds ratio improvement gerd symptoms confidence interval among subjects abdominal obesity decreased corresponding association weight loss waist reduction improvement esophagitis conclusions inferences weight loss waist reduction associated improvement gerd symptoms subjects general abdominal obesity weight loss waist reduction important treatment option obese patients
migration osteoclasts ocs circulation bone marrow bone surface plays critical role pathogenesis bone resorptive diseases rheumatoid arthritis osteoporosis date migration ocs remains unclear investigated gene expression profiling osteoclastic differentiation bone marrow derived macrophages bmms ocs microarray analysis identified genes overexpressed osteoclastic differentiation bmms among chemokine ccl showed robust regulation signal high expression ccl validated primary bmms precursor cell line raw differentiation ocs ccl neutralization decreased rankl induced precursor cell migration invasion matrigel coated transwell membranes assay vitro wound healing assay however ccl inhibition affect ocs differentiation differentiation associated gene expression ccl inhibition promoted pik phosphorylation minutes rankl stimulation raw study indicated chemokine ccl important regulator ocs migration via pik pathway providing novel therapy target bone resorptive diseases
quantitative qualitative analyses dissolution behavior various size clusters near fatigue crack tip underaged alloy cyclic loading performed means transmission electron microscopy tem atom probe tomography apt results showed driving force dissolution clusters increased increase clusters size therefore clusters smaller sizes easier dissolve number density small clusters atoms increased clusters atoms reduced fatigue crack tip region cyclic deformation large cluster could repeated cut moving dislocations two parts smaller clusters besides small clusters containing atoms also might form fatigue crack propagation fcp test fatigue crack tip region average equivalent radius large clusters atoms decreased fatigue deformation degrees sample obvious difference degrees sample result indicated dissolution large clusters degrees sample violent degrees sample elsevier rights reserved
three new series thiazoles quinolones thiazolidinones merged benzimidazole benzoxazole benzothiazole nuclei synthesized compounds subjected infrared nuclear magnetic resonance nuclear magnetic resonance mass spectrometry elemental analyses cytotoxic activity compounds evaluated breast mcf colon hct cell lines seven compounds values hence potent reference drug doxorubicin mcf hct respectively
mammalian cells respond various environmental stressors form stress granules sgs arresting cytoplasmic mrna protein translation element rna binding proteins virus induced sgs function different ways depending species virus however themechanismofsgregulation virus replication well understood study newcastle disease virus ndv triggered stable formation bona fide sgs hela cells activating protein kinase pkr eifa pathway ndv induced sgs contained classic sgmarkers cell internal antigen tia rasgtpase activatingprotein binding protein gbp eukaryotic initiation factors andsmall ribosomal subunit could disassembled presence cycloheximide treatment nocodazole amicrotubule disruptiondrug led formation relatively small circular granules indicating ndv infection induces canonical sgs furthermore role sgs ndv replication investigated knockdown tia tia related tiar protein critical components involved formation hela cells followed ndv infection results showed depletion tia ortiarinhibitedviral protein synthesis reducedextracellularvirus yields increasedglobal protein translation fish revealed ndv induced sgs contained predominantly cellular mrna rather viral mrna deletion tia tiar reduced mrna levels polysomes results demonstrate ndv triggers stable formationofbonafidesgs whichbenefit viralprotein translation andvirus replicationbyarresting cellularmrna sun dong wang zheng zhang meng zhan tan song qiu wang liao ding newcastle disease virus induces stable formation bona fide stress granules facilitate viral replication manipulating host protein translation
background poor lifestyle behaviors leading causes preventable diseases globally added sugars contribute diet energy dense nutrient poor increase risk developing obesity cardiovascular disease hypertension obesity related cancers dental caries methods results american heart association scientific statement writing group reviewed graded current scientific evidence studies examining cardiovascular health effects added sugars children available literature subdivided broad subareas effects blood pressure lipids insulin resistance diabetes mellitus nonalcoholic fatty liver disease obesity conclusions associations added sugars increased cardiovascular disease risk factors among children present levels far current consumption levels strong evidence supports association added sugars increased cardiovascular disease risk children increased energy intake increased adiposity dyslipidemia committee found reasonable recommend children consume cal approximate teaspoons added sugars per day avoid added sugars children years age although added sugars likely safely consumed low amounts part healthy diet children achieve levels making important public health target
demonstrate model order reduction technique system nonlinear equations arising finite element method fem discretization three dimensional quasistatic equilibrium equation equipped perzyna viscoplasticity constitutive model procedure employs proper orthogonal decomposition galerkin pod conjunction discrete empirical interpolation method deim purpose collect samples standard full order fem analysis offline phase cluster using novel means clustering algorithm pod deim algorithms employed construct corresponding reduced order model online phase sample current state system passed time step nearest neighbor classifier cluster best describes identified force vector derivative respect displacement vector approximated using deim system nonlinear equations projected onto lower dimensional subspace using pod constructed reduced order model applied two typical solid mechanics problems showing strain localization tensile bar wall compression three dimensional squarefooting problem authors published elsevier open access article license
field ofbiologic immunemodulators currentlymushrooming dizzying pace although biologics tested approved one indications unanticipated side effects label use contributed significantly understanding basic immune mechanisms involvement cytokines several apparently nonimmunologic diseases importance compartmentalized immune responses review attempt give bird eye view major biologics highlight insights implications derived secondary effects adverse reactions
four adult snow leopards uncia uncia radio monitored vhf one also via satellite year round altai mountains southwestern mongolia prey densities ibex capra siberica relatively low marked animals active night day within study area marked leopards showed strong affinity steep rugged terrain high use areas rich ungulate prey affinity habitat edges satellite monitored leopard moved kin consecutive days monitored home ranges determined standard telemetry techniques overlapped substantially least size however satellite monitored individual apparently ranged area least perhaps much since telemetry attempts ground frequently unsuccessful suspect marked animals likely large home ranges relatively low prey abundance area also suggested home ranges unreasonable expect though fold larger measured part snow leopard range home ranges snow leopards may larger suspect many areas thus estimation snow leopard conservation status must rigorously consider logistical constraints inherent telemetry studies relative abundance prey elsevier ltd rights reserved
increase apoptotic activity observed rabbit rat endometria following treatment aim study assess whether bax bcl signaling response could crucial role players mediating apoptosis rat uterus early pregnancy partial progesterone estrogen receptor antagonist functioning actively silence receptor gene associated transcription although increase apoptosis result administration previously reported rabbits specific apoptotic factors pathways involved driving process yet established immunofluorescent techniques used determine protein expression levels box bcl treated endometria days pregnancy bax bcl index used determine overall pro anti apoptotic setting day pregnancy following administration changes bax bcl gene expression levels consequence administration evaluated using qpcr protein gene expression analyses suggest induces change toward overall anti apoptotic signal within bax bcl pathway results suggest observed increase apoptosis following administration driven shift bax bcl ratio toward cell death estrogen receptors partially inactivated possibly regulated another apoptotic pathway society biology reproduction institute animal reproduction food research polish academy sciences olsztyn published elsevier urban partner rights reserved
one significant growing challenges modern medicine treatment chronic wounds marked nonuniform data concerns prevalence incidence chronic dermatosis particular venous ulcers ulcus cruris well impact health related quality life practical economic parameters success different therapies aim work examine epidemiology chronic wounds particular age associated venous ulcers impact health related quality life treatment regimen practical economic parameters success different therapies performed analysis data care venous ulcers germany based secondary data barmer gek comparison data nhs kent community health trust study analysis studies concerning structures processes critical success factors treatment chronic wounds including economic effects early causal therapy treatment based stage wound consequent goal oriented interdisciplinary care relapse prophylaxis critical successful healing venous ulcers costs treatment significantly correlate duration treatment reduced using guideline based concepts treatment chronic wounds treatment success particular regard cost benefit considerations optimized telemedicine networks key players treat chronic wounds
identify presence environmental factors linked onset allergies asthma homes children participating early detection program identified sensitivity common allergens region sonora mexico walkthrough assessment carried homes sensitized children research tools questionnaire environmental checklist proposed lowell healthy homes program university massachusetts lowell results showed presence environmental allergen sources children study sensitized well environmental conditions habits determine quality indoor air households related triggering allergies asthma population statistically significant association found visual observation dust inside homes sensitivity children dust mites dust found inside home relevant environmental factor related positive cases ige children early detection allergies children study methodology used investigation provided useful framework design plans intervention alternatives homes prevent development allergies asthma panorama plans designed multidisciplinary approach impact social environmental economic benefits family improving living conditions study population contributing sustainable development goals united nations
study design retrospective cohort study single institution objective determine effect preoperative depression hospital consumer assessment healthcare providers systems hcahps survey scores lumbar fusion population summary background data hcahps surveys used assess quality patient experience directly influences reimbursement hospital systems spine surgeons nationwide untreated depression linked worse functional outcomes spine surgery however aimed elucidate whether hcahps survey responses different depressed patients methods prospectively collected functional outcome data including patient health questionnaire euroqol five dimensions pain disability questionnaire analyzed preoperatively preoperative patient health questionnaire scores greater equal moderate severe depression defined depressed cohort patients hcahps responses obtained individual allowing real world analysis outcomes population results patient cohort depressed patients younger female full disability lower scores euroqol five dimensions pain disability questionnaire preoperatively approximately depressed patients felt doctors treated respect compared patients without depression also depressed patients felt nurses treated less respect physicians listen carefully multivariate regression analysis revealed patients preoperative depression higher odds patients feeling less respected physicians nurses multivariate analysis also revealed depression independent predictor lower patient satisfaction nursing response needs conclusion patients undergoing lumbar fusion preoperative depression shown negative effect patient experience measured hcahps survey results suggest depression may modifiable risk factor poor hospital experience
lightweight model predictive controller class discrete event systems developed target first first fifo systems precedence relations represented directed acyclic graph using max plus algebra system behavior described set linear equations referred state space representation using representation address problem adjusting system parameters determining optimal control inputs given reference signals determine system parameters formulate solve optimization problem using branch bound method number constraints reduced optimal control inputs determined since part often bottleneck online control propose two methods efficient computation thereof first method beneficial systems sparse adjacency matrices small scale systems greater prediction horizon contrast second approach beneficial larger scale systems smaller prediction horizon effectiveness proposed framework verified numerical simulations
paper develops methodology uses thermoeconomic functional diagram applied allocating cost products obtained plant afterwards demonstrates possible calculate marginal cost production methodology adopted includes plant exergetic analysis development function system identification physical diagram plant construction thermoeconomic functional diagram determination expressions plant exergetic functions methodology also includes determination parameters investments maintenance operation raw materials canola oil catalysts methanol glycerine natural gas utility costs electricity steam water result said simultaneously production biodiesel hydrogen suitable technology minimize biodiesel production cost thermoeconomic cost biodiesel production diminished compared values previolisly published present literature relation hydrogen production thermoeconomic costs values closer compared ones identified literature contribution scientific knowledge said obtained results shows high performance simultaneous biodiesel hydrogen production especially glycerine processed valuable energetic matter words considering economic aspects associated exergy conception order develop tool assist equipment operation well optimize biodiesel plant design also shows biodiesel production plant hydrogen technology sustainable traditional one paper aims innovate production process biodiesel incorporating hydrogen production process glycerine steam reforming elsevier ltd rights reserved
work studies effect tensile strain pore size flow capability needle punched nonwoven geotextiles laboratory tests conducted investigate variations pore size thickness porosity mean discharge velocity water geotextile samples permittivity different uniaxial biaxial tensile strains ranging comparison test predicted results suggests values shape factor beta describing path tortuosity dimensionless parameter account evaluations permeability filtration opening size needle punched nonwoven geotextiles various tensile strains experimental data collected three needle punched nonwoven geotextiles show strained geotextiles exhibit smaller pore size unstrained geotextiles mean discharge velocity water strained geotextiles tends decrease initially increase tensile strain geotextiles low strain regions decreasing trend mean discharge velocity reverses geotextiles submitted higher strain
describe main features developed software tool namely plate motion pem allows inferring euler pole parameters inverting observed velocities set sites located rigid block inverse problem pem allows also calculating expected velocity value point located earth providing euler pole direct problem pem updated version previous software tool initially developed easy use file exchange gamit globk software package software tool developed matlab framework previous version includes set matlab functions files guis fig files map data files mat files user manual well example input files new changes pem include bugs fixed improvements code improvements statistical analysis new input output file formats addition pem run majority operating systems tool open source freely available scientific community
aim investigate serum omentin vaspin levels cirrhotic patients assess relationship levels hemostatic parameters metabolic abnormalities cirrhosis severity etiology methods fifty one cirrhotic patients portal vein thrombosis analyzed serum omentin vaspin levels measured commercially available direct enzyme linked immunosorbent assays elisas assess platelet activity following tests performed using multiplate platelet function analyzer adp induced platelet activation test cyclooxygenase dependent aggregation test aspi test von willebrand factor glycoprotein dependent aggregation using ristocetin test risto test test thrombin receptor activating peptide induced activation thrombin receptor sensitive iib iiia receptor antagonists results omentin vaspin serum concentrations significantly decreased patients portal vein thrombosis pvt prothrombin levels significantly increased patients pvt thrombin receptor activating peptide trap test results significantly lower pvt group significant differences adipokines serum levels found regarding etiology severity liver cirrhosis assessed according child pugh model end stage liver disease meld scores significant increase trap aspi risto high test results patients lower meld scores serum omentin vaspin levels significantly regulated patients without insulin resistance respectively positive relationship omentin vaspin levels found patients analyzed among pvt conclusion serum omentin levels increased patients without pvt cirrhosis origin grade affect omentin vaspin levels analyzed adipokines influence platelet activity
background several new rehabilitation modalities proposed anterior cruciate ligament acl reconstruction among trigger point dry needling trp might useful treatment myofascial pain syndrome associated acl reconstruction reduce pain intensity increase knee flexion range modify mechanical properties quadriceps muscle late stage rehabilitation date first randomized clinical trial support use trp early rehabilitation process acl reconstruction aim study determine pain intensity range motion rom stability functionality improvements adding quadriceps vastus medialis trp rehabilitation protocol provided subacute acl reconstructed patients methods randomized single blinded clinical trial nct included subacute patients surgical reconstruction complete acl rupture patients randomized intervention groups trp pain intensity rom stability functionality measured baseline immediately hours week weeks first treatment results comparing statistically significant differences conclusion quadriceps vastus medialis trp conjunction rehabilitation protocol subacute patients surgical reconstruction complete acl rupture increases rom short term functionality short mid term although increase pain intensity addition trp detected beyond immediately first treatment furthermore stability seem modified trp
king devick test rapid number naming visual performance measure captures saccadic eye movements patients multiple sclerosis slowed test times associated neurologic disability reduced quality life assessed eye movements test identify characteristics associated slowed times participants performed computerized test video oculography item national eye institute visual functioning questionnaire nei vfq item neuro ophthalmic supplement measured vision specific quality life vsqol among participants age years range controls age years range associated significantly longer worse times linear regression models accounting age test times slower among patients higher worse expanded disability status scale scores average inter saccadic intervals isi significantly longer participants compared controls highly associated prolonged times participants generated greater numbers saccades vsqol scores reduced patients longer worse times longer isi patients slowed times may attributable prolonged isi greater numbers saccades test requisite eye movements capture vsqol make rapid number naming strong candidate efferent visual performance measure
childhood adolescence coincide rapid structural functional maturation brain networks implicated theory mind tom however impact paediatric traumatic brain injury tbi development higher order skills well understood tom partitioned conative tom defined ability understand indirect speech acts involving irony empathy used influence mental affective state listener affective tom concerned understanding facial expressions often used social purposes convey emotions want people think feel sample children mild severe tbi typically developing controls study examined effect paediatric tbi affective conative tom evaluated respective contributions injury related factors injury severity lesion location non injury related environmental variables socio economic status ses family functioning long term tom outcomes results showed poorest tom outcomes documented association mild complicated moderate tbi rather severe tbi lesion location ses significantly contribute conative affective tom post injury family affective responsiveness strongest significant predictor conative tom results suggest clinicians exercise caution prognosticating based early clinical indicators group individual level outcome prediction incorporate assessment range injury non injury related factors moreover affective quality post injury family interactions represents potentially modifiable risk factor might useful target family centred interventions designed optimise social cognitive outcomes paediatric tbi
control voltage proton exchange membrane fuel cell pemfc one important types fuel cell system load variations described fuel cell output voltage kept constant value load variations controller designed purpose accordingly modified pid controller proposed optimized based hybrid particle swarm optimization time varying acceleration coefficients hpsotvac bacteria foraging algorithm bfa order use hybrid technique first proposed problem written optimization problem consists objective function constraints achieve desirable controller hybrid technique applied solve problem simulation results operated various loads time domain results show efficiency proposed controller contrast previous controllers simulation results demonstrate good accuracy proposed controller performance considering problem solving
investigated association arggln polymorphism dna repair gene xrcc chronic myeloproliferative diseases patients chronic myeloid leukemia cml patient polycythemia vera patients essential thrombocythemia patients myelofibrosis controls included study genotyped polymorphism xrcc gene using polymerase chain reaction real time taqman assay detection quantification jak gene mutation allele burden carried means pyromark pyrosequencing presence least one xrcc gln allele found significantly different patients cml comparison controls presence xrcc gln allele associated resistance imatinib found interactions xrcc genotype level jak allelic burden data suggest significance xrcc gene product control precursor cells myeloid differentiation cml cells testing arggln polymorphism xrcc gene may useful assessment prognosis treatment efficacy
novel driving method implemented high frequency electromagnetic isolation proposed paper hardware designing schematic diagram software configuration method presented corresponding operating principle analyzed detail based digital control chip analog circuits proposed driving method applied real time varying pulse width control signal duty cycle ratio control pulse regulated range novel driving method achieve advantages high insulation high common mode suppression also merits low cost fast dynamic response speed suitable isolation amplification high frequency switching control pulse signal finally experimental results show proposed driving method paper effective
currently many european countries public protests opinion polls election forecasts election results create concerns regarding radicalization political culture seems patterns arguments appear particularly directed one religion islam paper examines question whether europe general tendency skepticism defense towards islam members predominant reasons attitude populations might considering socio psychological approaches determine mechanisms development islamophobic attitudes comparative picture situation drawn results reveal primarily wide existing feeling threat identity leads fear many citizens islam muslims essential role similarity levelling para social contacts via media result increased conflict potential societies medium term lead significant threat social cohesion well radicalization political opinions
introduction tolosa hunt syndrome ths rare entity characterized unilateral orbital pain associated paresis one oculomotor cranial nerves caused granulomatous inflammation cavernous sinus superior orbital fissure orbit low prevalence ths broad spectrum disorders could cause painful ophtalmoplegia resulted stricter diagnostic criteria ths latest edition international classification headache disorders current criteria require demonstration granuloma magnetic resonance imaging biopsy diagnosis could difficult initiation treatment delayed due high variablity clinical presentation tsh reducing number patients based clinical presentation could classified ths fullfil diagnostic criteria complicates establishing correct diagnosis case report hereby presented eight patients diagnosed treated ths inspite exclusion causes painful ophtalmoplegia granuloma could demonstrated half patients clinical presentation ths patients without shown granuloma significantly differ concerning headache characteristics localization intensity quality duration preceding cranial nerve palsy response steroids affected cranial nerve disease course response treatment well types diagnostic procedures performed ruling diseases extensive differential diagnosis painful ophthalmoplegia conclusion significant difference ths patients without demonstrated granuloma
stress tolerance generally declines age result functional senescence age dependent alteration stress tolerance also occur early adult life drosophila melanogaster evidence decline young adults reported thermotolerance known whether early adult life entails general stress tolerance reduction whether response peculiar thermal traits present work designed investigate whether newly eclosed melanogaster adults present high tolerance range biotic abiotic insults found tolerance abiotic stressors tested desiccation paraquat hydrogen peroxide deltamethrin malathion high newly eclosed adults dramatically declining next days adult life clear age related pattern found resistance biotic stress septic fungal infection starvation results suggest newly eclosed adults present culminating level tolerance extrinsic stress likely unrelated immune process argue stress tolerance variation young age likely residual attribute previous life stage ontogenetic carryover feature related posteclosion development
paper propose ecological view smart home seen interconnected collection smart objects work together provide services inhabitants review home technologies historical context home personal habitat provides services inhabitants draw lessons profusion new services made possible introduction electricity home century examine possible metaphors smart homes including smart home inside autonomous robot smart home ecosystem smart objects providing services propose taxonomy smart home services discuss examples class service conclude discussion required system qualities potential show stoppers
electroconvulsive therapy used frequently treatment many chronic acute psychiatric illnesses children common psychiatric indications pediatric electroconvulsive therapy refractory depression bipolar disorder schizophrenia catatonia autism addition relatively new indication treatment pediatric refractory status epilepticus anesthesiologist may called upon assist care challenging vulnerable patient population unique factors pediatric electroconvulsive therapy include potential need preoperative anxiolytic inhalational induction anesthesia must weighed detrimental effects anesthetic agents evoked seizure quality required successful treatment dexmedetomidine likely appropriate preoperative anxiolytic oral benzodiazepines relatively contraindicated methohexital though becoming less available many institutions remains gold standard induction anesthesia pediatric electroconvulsive therapy though ketamine propofol sevoflurane becoming increasingly viable options proper planning communication multidisciplinary teams involved care children presenting electroconvulsive therapy treatments vital mitigating risks achieving greatest therapeutic benefit
discussion drone warfare particular massacre people uruzgan province afghanistan argue drone warfare embodied embodying drawing posthuman feminist theorists donna haraway katherine hayles understand turn toward data machine intelligence human process decisionmaking deprives humans sovereignty form embodiment reworks undermines essentialist notions culture nature biology technology intermediation algorithmic visual affective modes embodiment drone warfare reproduces gendered racialized bodies enable necropolitics massacre finally category gender demonstrates flaw supposed perfectibility algorithm removing issues identity prejudice security practices well perceptions drone assemblages comprising sublime technologies perfect analysis vision gender mode embodiment category analysis removed algorithmic war rather put service violence enables
extracellular vesicles originate diverse subcellular compartments released extracellular space transferring cargoes target cells tissues emerge novel regulators intercellular communication adjacent remote cells vesicle composition biological content specific signatures cellular activation injury potential diagnostic prognostic biomarkers raised significant interest cardiovascular diseases characterization circulating vesicles nonvesicles bound nucleic acids represents valuable tool diagnosing monitoring cardiovascular diseases recently referred liquid biopsy circulating extracellular vesicles offer noninvasive almost continuous access circulating information disease state epidemiological investigations finally genetic engineering cell specific application extracellular vesicles could display novel therapeutic option treatment cardiovascular diseases review summarize current knowledge extracellular vesicles diagnostic prognostic biomarkers well potential applications longitudinal epidemiological studies cardiovascular diseases
aim aim article evaluate clinical cost implications failed endoscopic hemostasis patients gastroduodenal ulcer bleeding methods retrospective claims analysis medicare provider analysis review medpar file conducted identify hospitalizations gastroduodenal ulcer bleeding year main outcome measures compare cause mortality total length hospital stay los hospital costs payment patients managed one upper gastrointestinal ugi endoscopy versus one ugi endoscopy requiring interventional radiology guided hemostasis irh surgery failed endoscopic attempt results medpar claims data evaluated hospitalizations reported one ugi endoscopy reported ugi endoscopy reported irh failed endoscopy reported surgeries failed endoscopy cause mortality significantly lower patients underwent one ugi endoscopy compared patients requiring endoscopy irh surgery endoscopy eight days irh nine days surgery days endoscopy irh surgery conclusions failure achieve hemostasis index endoscopy significant clinical cost implications feasible repeat endoscopy must attempted followed irh surgery preferably reserved last resort patients fail treatment measures
although half century since first noted author mordecai richler writes novels problematic portrayal women little critical work closely examining aspect works essay examines construction women characters richler corpus whether textual grounds reading novels body work threaded sexist overtones despite temporizing tendency richler development novelist relation several social issues including gender roles conclude idealized patterns male female relations always traditional based conventional notions beauty femininity women subordination
introductionlittle known effect body mass index bmi efficacy safety testosterone therapy hypogonadal men prior noncomparative trial demonstrated testosterone gel restored testosterone levels hypogonadal men generally well tolerated aimthis post hoc analysis evaluated influence bmi pharmacokinetics testosterone therapy men low testosterone methodsmen aged applied testosterone gel front inner thigh daily days starting dose day could adjusted days patients split categories depending baseline bmi tertile tertile tertile main outcome measuresefficacy end points average serum total testosterone concentrations hours maximum serum testosterone concentrations day adverse events recorded resultsthe efficacy analysis included men low testosterone mean age years tertiles respectively defined serum testosterone baseline testosterone levels comparable across bmi tertiles days treatment testosterone gel day patients tertiles respectively achieved serum testosterone concentrations physiologic range mean average daily dose day higher participants tertiles tertiles gel generally well tolerated skin reactions commonly reported adverse event conclusionsin study daily application testosterone gel effective returning serum testosterone physiologic levels men low testosterone high bmi although required dose affected bmi dobs norwood potts gould chitra testosterone gel normalize testosterone concentrations men low testosterone regardless body mass index sex med
purposemore adults experience mental health substance use conditions annually yet less half receive treatment study explored rural participants behavioral health conditions pursue receive care examined factors differed across american indian geographic subpopulations methodswe undertook qualitative follow study statewide survey unmet mental health substance use needs south dakota conducted semistructured phone interviews purposive sample key informants varying perceptions need mental health substance use treatment resultswe interviewed participants mental health substance use occurring disorders twenty participants lived rural communities overlap tribal land twelve participants lived reservation discrepancy actual perceived treatment need related participants defined mental health alcohol drug use problems mental health disorders excessive alcohol consumption seen normal part life rural reservation communities seeking mental health care maintaining sobriety viewed result individual willpower frequently related substantial life event childbirth participants recommended treatment gaps addressed multicomponent community level interventions discussionthis study describes rural populations view mental health alcohol drug use enhancing access care addressing discordant perceptions improving community based interventions may increase treatment uptake
post transplant erythrocytosis infrequent complication reported allogeneic hematopoietic stem cell transplantation allo hsct aplastic anemia acute myeloid leukemia chronic myeloid leukemia pre disposing factors treatment clearly defined present post transplant erythrocytosis cases studies conducted distinguish pathogenesis follow rare complication
toxoplasma gondii toxo neuroinvasive protozoan parasite induces formation persistent cysts mammalian brains infects approximately million people united states annually latent toxo infection implicated etiology psychiatric disorders especially schizophrenia scz correlated modestly impaired cognition acoustic startle response asr reflex seen mammals mediated simple subcortical circuit provides indicator neural function previously reported association toxo slowed acoustic startle latency index neural processing speed sample schizophrenia healthy control subjects alterations neurobiology toxo latent infection may specific schizophrenia therefore examined toxo relation acoustic startle urban predominately african american population mixed psychiatric diagnoses healthy controls physiological diagnostic data along blood samples collected outpatients treated inner city hospital toxo status determined elisa assay toxo specific igg discrete titer calculated based standard cut points indicator seropositivity toxo specific igg concentration served serointensity series linear regression models used assess association toxo seropositivity serointensity asr magnitude latency models adjusting demographics psychiatric diagnoses ptsd major depression schizophrenia psychosis substance abuse asr magnitude higher toxo seropositive subjects compared seronegative individuals effect pronounced models toxo serointensity adjusted sociodemographic covariates remained significant psychiatric diagnoses stepped models toxo showed association startle latency unadjusted model toxo associated latency models included demographic factors stepping individual psychiatric disorders found significant association latency diagnosis ptsd psychiatric diagnoses subjects ptsd longer startle latency mechanism toxo infection associated high startle magnitude known possible mechanisms include toxo cyst burden brain parasite recrudescence molecular mimicry host epitope toxo future studies focus neurobiology underlying effects latent toxo infection potential inroad development novel treatment targets psychiatric disease elsevier inc rights reserved
granulocyte transfusions long history used patients neutropenia neutrophil dysfunction prevent treat invasive fungal infections however limited conflicting data concerning clinical effectiveness considerable variations current granulocyte transfusion practices uncertainties benefit adjunct modern antifungal therapy review provide overview granulocyte transfusions summarize evidence role prevention treatment invasive fungal infections
objective individual occurrence depression insomnia risk factor irritable bowel syndrome ibs researchers evaluated association comorbid depression insomnia ibs aim present study explore relationship ibs coexistence depression insomnia korean population based cohort study methods total individuals enrolled korean genome epidemiology study analysed participants diagnosed ibs based rome criteria regarding depressive symptoms subjects sub divided three groups based beck depression inventory bdi score insomnia defined positive response least one three questions sleep states results odds ratio ibs increased proportionally depressive symptoms worsened middle tertile highest tertile subjects insomnia showed higher ibs without insomnia joint analysis bdi insomnia odds ibs significantly higher bdi tertiles insomnia corresponding bdi tertiles without insomnia significant interaction effect bdi tertile insomnia ibs conclusion presence depression insomnia significantly associated ibs compared individual occurrence prospective investigations needed explore possible causality morbid depression insomnia ibs elsevier inc rights reserved
individuals increasingly turning internet search health information however scholarship yet carefully examine online health information seelcing contributes post search health behaviors including sharing information found search others combining insights appraisal theory emotions social cognitive theory study used naturalistic experiment test model role post search emotions shaping post search cognitions behavior context influenza moreover vast amount online health information dubious quality makes task finding relevant information difficult therefore experiment also tested approach improving online health information seeking process tailoring search engine results influenza emotional action tendencies users study finds varied effects different post search discrete emotions fear hope contentment interest inspiration explores social cognitive mediators perceived relevance shape post search attitudes behaviors results underscore importance studying discrete emotional reactions online health information order better predict attitudinal behavioral outcomes popular avenue acquiring health information elsevier ltd rights reserved
background skin aging associated anatomical physiological changes changes pathological nevertheless reduced functional skin capacity increases susceptibility skin diseases functional disorders especially old age clinical manifestation skin changes differs greatly individuals purpose contribution focuses critical reflection concept preventative skin care skin health promotion aged results preventive skin care aged includes activities cleanse care skin contribute health promotion reduce probability developing skin disorders diseases preventive skin care aged classified primary secondary tertiary prevention empirical evidence supporting individual interventions heterogeneous conclusion formally developed guidelines recommendations basic skin care aged thus preventive skin care elderly likely underused
objectives examined rheumatologists motivation prescribing biosimilars assessed treatment preferences relation prescribing behavior explored patient attitudes biosimilars methods data taken adelphi real world biosimilars programme real world cross sectional study undertaken german rheumatologists patients rheumatoid arthritis ankylosing spondyloarthritis psoriatic arthritis rheumatologists provided data prescribing behavior attitudes toward biosimilars invited next eight eligible consecutive consulting patients complete questionnaire rheumatologists split investigative conservative groups results overall rheumatologists patients participated biosimilars accounted rheumatologists would prescribe biooriginator rather biosimilar first second line therapy unrestricted patients showed reluctance accept biosimilars small proportion patients unhappy switched biooriginator biosimilar satisfaction treatment highest patients started treatment biooriginator prior biosimilar availability patient concerns starting treatment biooriginator biosimilar included knowing enough drug potential side effects potential long term problems conclusion study results demonstrate reluctance patients accept biosimilars need educate patients unsure allow involved decision making highlighting importance patient physician communication remains need research nonclinical switching long term impact prescribing biosimilars
systematic non probabilistic reliability analysis procedure structural vibration active control system unknown bounded parameters proposed state space representation active vibration control system uncertain parameters presented compared robust control theory always conservative reliability based analysis method suitable deal uncertain problem stability core closed loop feedback control system design stability criterion adopted act limited state function reliability analysis uncertain parameters without enough samples modeled interval variables interval perturbation method employed estimate interval bounds eigenvalues used characterize stability closed loop active control system formulation defining reliability active control system based stability discussed novel non probabilistic reliability measurement index discussed used determine probability stability based area ratio feasibility efficiency proposed method demonstrated two numerical examples elsevier ltd rights reserved
inadequate regulation spatial development origin current global crisis increases years crisis unequal distribution wealth importance related risks democracy draw attention systems spatial governance planning states regulate spatial development europe countries affected unequal effects crisis spatial planning systems traditionally based preventive assignation rights land use development plan systems countries established beforehand new rights land use spatial development rather assigned public control development projects distributional effects despite evidence models operate better others ensuring public government spatial development improvement spatial planning systems however limited complex nature institutional technologies especially context crisis planners responsible increase public awareness concerning role spatial governance economic social life
two new steroidal saponins beta hydroxy alpha spirost one beta galactopyranoside hostasaponin alpha beta dihydroxy alpha spirost one beta galactopyranoside hostasaponin together new natural product alpha beta dihydroxy alpha pregn one isolated rhizomes hosta plantaginea perennial herb used mainly ornamental plant folk medicine fungal infection various inflammations active evaluation results showed possess potent inhibition activity candida albicans mic values less
spontaneous inducible forms chronic urticaria pose significant economic burden adverse effect patients quality life international guidelines practice parameters diagnosis management chronic urticaria recommend performing thorough patient history physical examination conducting limited routine laboratory testing taking stepwise approach treatment documents differ several areas order diagnostic procedures treatment patients non responsive standard dose antihistamines patients chronic urticaria visit specialist typically treated second generation antihistamines recommended first line treatments advantages disadvantages treatment option taken consideration selecting therapies beyond antihistamines greater awareness international guidelines practice parameters likely improve quality care patients chronic urticaria
state recognition disconnecting switches important substation automation effective computer vision based automatic detection state recognition method disconnecting switches proposed taking advantage important prior knowledge disconnecting switch method designed using two important features fixed contact facet disconnecting switches first histograms oriented gradients hog fixed contact used design linear discriminant analysis lda target detector position disconnecting switches distinguish loci usual cluttered background discriminative norm gradient field ngf feature used train support vector machine svm state classifier discriminate disconnecting switch states finally experimental results compared methods demonstrate proposed method effective achieves low miss rate delivering high performance precision recall rate addition adopted approach efficient potential work practical substation automation scenarios
riparian floodplain tree like emergent vegetation alter significantly flow field lead complicated three dimensional flow patterns characterized increased turbulence production potential induce morphological changes canopy presence tree like vegetation leads formation lee wake vortices induce strong subcanopy flow present experimental study employs artificial rigid tree like emergent vegetation elements relatively simple structure order investigate canopy effects flow field specifically tree like canopy simulated placing element top wooden rod simulating trunk three elements equal encircling diameter examined canopy tree like vegetation namely circular cylinder two hexagonal arrays comprising smaller circular cylinders two different individual diameters experiments conducted long laboratory flume velocity measurements carried acoustic doppler velocimeter results show canopy porosity direct impact subcanopy flow intensity required distance flow needs recover addition subcanopy flow disrupts formation steady wake region behind entire porous element inhibits development recognizable von karman vortex street
ability timely process significant amounts continuously updated spatial data mandatory increasing number applications parallelism enables applications face data intensive challenge allows devised systems feature low latency high scalability paper focus specific data intensive problem concerning repeated processing huge amounts range queries massive sets moving objects spatial extent queries objects continuously modified time tackle problem significantly accelerate query processing devise hybrid cpu gpu pipeline compresses data output saves query processing work devised system relies hoc spatial index leading problem decomposition results set independent data parallel tasks index based point region quadtree space decomposition allows tackle effectively broad range spatial object distributions even skewed also deal architectural peculiarities limitations gpus adopt non trivial gpu data structures avoid need locked memory accesses favouring coalesced memory accesses thus enhancing overall memory throughput best knowledge first work exploits gpus efficiently solve repeated range queries massive sets continuously moving objects possibly characterized highly skewed spatial distributions comparison state art cpu based implementations method highlights significant speedups order depending dataset copyright john wiley sons ltd
background high levels distress expected shortly diagnosis breast cancer distress thermometer commonly used screen distress using cutoff score however score might appropriate detecting distress women recently diagnosed breast cancer objectives aims study establish optimal cutoff score detecting high distress shortly breast cancer diagnosis correlate score reported problems methods selected study dutch women completed hospital anxiety depression scale within month breast cancer diagnosis receiver operating characteristic analysis scores performed hospital anxiety depression scale used criterion standard level distress sensitivity specificity positive predictive value negative predictive value score calculated results total women participated study optimal cutoff score detecting distress sensitivity specificity positive predictive value negative predictive value emotional problems frequently reported concerns conclusion consider cutoff score shortly breast cancer diagnosed optimal identify women high distress therefore risk chronic distress implications practice findings clinically important enable healthcare professionals direct time resources need assistance
file super abstraction hypothetically huge volume information stored containers disk blocks persists long time memory abstraction file linear array bites blocks bytes accessed multiple clients controlled file system file system function disk seek read maximum information container maps file names offsets disk blocks better read write operations file system logic device information stockpiled effectively retrieve file system manages references pointers memory block assist seek information feasible manner without data would placed large heaps memory location unknown operating system manage resources effectively file system structure sense rules accustomed managing clusters data termed file system current age age high performance information processing intelligent knowledge generation urges better scalable file system current file system come numerous limitations architecture design pattern limitations operational component failure reliability issue data decomposition fault tolerance etc manuscript give first survey first step towards synchronized research first research article scalable file system facilities view map new scalable file system beta survey methodology incorporated pattern abstract methodology scope writing every research article related scalable file system survey key point answer conclusion luster scalable file system used core development world top supercomputers fulfills key space scalable file system future research work would implementation luster file system evaluation parameters global name space iops luster file size clients ost used throughput mbps read write pattern evaluation
accurate condition assessment service infrastructure systems critical system wide prioritization decisions current protocols require lengthy inspections expensive equipment examine large infrastructure systems furthermore changes inspection protocols time create discontinuities recording understanding time history structure address challenges systematic adaptive technique converting two dimensional digital images three dimensional models developed goal creating high resolution scale accurate inspection records developed reconstruction technique utilizes multiscale imaging reconstruct structure varying levels details geometric complexity captured images converted photorealistic accurate dense scene reconstructions utilizing hierarchical adaptation dense structure motion dsfm algorithm result approach virtual model structure accurate geometry high fidelity representation fine details accuracy completeness adaptability feasibility developed method compared terrestrial laser scanner tls conventional dsfm methods experimental findings direct comparison generated point clouds indicate developed hierarchical technique consistently produces dense point clouds capable resolving details order magnitude improvement existing methods developed technique also allows user controlled point cloud density significant benefit current reconstruction methods american society civil engineers
although older adults studied victims violence geriatric patients display violent behavior purpose present review explore phenomenon criminal violations violent acts people dementia authors used pubmed search medline database sources original research review articles criminal violent manifestation demented patients combining terms criminal manifestation violence aggressive behavior homicide suicide homicide suicide together dementia possible biomarkers violence considered present review highlights risk factors violence patients suffering dementia reviews literature criminal violations homicidal suicidal behavior patient group
objectiveparkinson disease adversely affects oral health however informative value xerostomia compared objective parameters impact quality life qol still unclear study aimed explore whether xerostomia correlates hyposalivation define impact related qol materials methodswhole stimulated saliva wss collected patients matched healthy controls objective parameters community periodontal index treatment needs plaque gingivitis index mucosa situation cheilitis angularis questionnaires german oral health impact profile ohipg visual analogue scale vas xerostomia yes unified parkinson disease rating scale assessed resultseighty seven per cent patients showed hyposalivation controls patients reported xerostomia none controls ohipg impaired patients compared controls patients xerostomia reported mean vas values wss correlate vas values conclusionshalf patients reported xerostomia underestimated xerostomic status higher probability healthy controls wss reflect grade xerostomia patients suffered impaired related qol dental teams overlook oral health risks
backgroundabout children affected allergic rhinoconjunctivitis although main symptomatic treatments intranasal corticosteroids incs daily demand oral antihistamines remains unclear treatment provides best relief symptoms therefore study examines whether daily use incs superior demand use oral antihistamines demand methodsa single blinded randomized controlled trial children aged years pollen related patients received either incs daily fluticasone propionate incs demand fluticasone propionate oral antihistamine demand levocetirizine months grass pollen season daily online symptom diary nose eye symptoms completed primary outcome percentage symptom free days resultsa total children randomized percentage symptom free days favour incs demand compared incs daily difference significant antihistamine demand group symptom free days difference compared incs daily significant patients incs demand group used average less fluticasone patients incs daily group study period conclusionsthis trial three parallel treatment groups shows incs daily superior incs demand antihistamine demand regarding number symptom free days demand incs strategy advantage lower overall corticosteroid exposure less costs
new open source project evaluation tool entitled materials engineering tetrahedron met developed determine economic viability materials design selection processing validation costs associated infrastructure based project met improves project design providing economic perspective traditional materials science tetrahedron relating microstructure processing property performance introduction value based economic costs side tetrahedron resulting size distortion regular tetrahedron illustrates balance system component material fabrication project detailed met model also allows increased budget efficiency potential improved identification cost saving mechanisms use financial tools met aid engineering project management providing easy reliable metrics compare projected costs versus desired outcomes expansion use types tools reduce risks initial stages project design illustrate strength met several example tetrahedra generated demonstrating various uses applications new program
work presents ensemble attractor neural networks ann modules increases patterns storage similar computational cost compared single module ann system build ensemble ann components divide uniform random patterns set disjoint subsets learning stage subset assigned different component way larger overall number patterns stored ann ensemble modules moderate pattern load able retrieve corresponding assigned subset desired quality allowing noise retrieval able recall larger number patterns discriminating pattern subsets assigned component ensemble showed ann ensemble system units able approximately triple maximal capacity single ann similar wiring costs tested modularized ann ensemble different levels component dilution keeping constant wiring costs approach could implemented instance parallel computing order tackle computational costly real world problems elsevier ltd rights reserved
backgroundatopic dermatitis common chronic skin disorder may persist adulthood however prevalence comorbidities patients well characterized considered systemic disorder like psoriasis raised need data comorbidity profile patients assess potential risks benefits complications management patients described occurrence medical psychiatric comorbidities associated risk factors adults compared psoriasis general population methodsall danish individuals aged years hospital inpatient ambulatory diagnosis psoriasis study period january december linked administrative registers resultsoverall prevalence smoking alcohol abuse higher among patients general population lower psoriasis patients similarly patients risk factors higher prevalence comorbidity general population lower prevalence reduced risk compared psoriasis patients except use anxiolytics higher severe prevalence diabetes lower psoriasis patients well general population controls conclusionsdespite increased risk various medical psychiatric comorbidities compared general population controls adult patients markedly lower prevalence cardiovascular disease psoriasis patients however prevalence psychiatric comorbidity tobacco smoking alarmingly high severe patients might target intervention patient management
background humans rodents impaired phytanic acid metabolism accumulate toxic stores deleterious effects multiple organ systems ruminants certain fish obtain microbial degradation dietary chlorophyll chlorophyll derived precursors contrast humans derive chlorophyll instead normally obtain meat dairy fish products results captive apes old world monkeys significantly higher red blood cell rbc levels relative humans subjects fed deficient diets given adverse health effects resulting accumulation investigated molecular evolution thirteen metabolism genes apes old world monkeys new world monkeys non human primate nhp orthologs predicted encode full length proteins marmoset phyh gene containing rare functional splice donor dinucleotide acox scp pecr sequences amino acid positions accelerated substitution rates amacr significant variation evolutionary rates apes relative primates conclusions unlike humans diverse captive nhps deficient diets rich plant products substantial rbc levels favored hypothesis nhps derive significant amounts degradation ingested chlorophyll gut fermentation correct raises possibility rbc levels could serve biomarker evaluating digestive health captive nhps furthermore evolutionary rates several genes relevant metabolism provide candidate genetic adaptations nhp diets
purpose medulloblastoma prevalent childhood brain cancer children medulloblastoma typically receive combination surgery radiation chemotherapy survival rate high survivors often sequelae radiotherapy entire developing brain spinal cord ongoing genetic studies suggested decreasing dose radiation might possible among children favorable molecular variants however may result increased disease recurrence need investigate nature trade offs individuals willing make regarding treatment medulloblastoma method used best worst scaling estimate importance attributes affecting general public decision making around treatment medulloblastoma conducting focus groups selected three relevant attributes accuracy genetic test probability serious adverse effects treatment survival rate using paired method applied conditional logit model estimate preferences results total respondents female average age years answered questionnaires coefficients statistically significantly different zero attribute levels adverse effects survival rate impact individuals stated decision making conclusion overall respondents showed high sensitivity children experiencing disability particularly setting good prognosis however among children poor prognostic molecular variants participants showed tolerance child mild partial disability compared low rate survival
flat topped main cables long span suspension bridge may occur galloping wind field construction however little galloping flat topped main cables found existing literature important address problem present paper two main parts numerical simulation wind tunnel test first part numerical simulation using method cfd computational fluid dynamics implemented obtain aerodynamic coefficients six main cables different cross sections different wind attack angles degrees corresponding den hartog coefficients six cables angle attack determined predict transverse galloping moreover den hartog coefficients six cables compared results show generally number wind attack angles corresponded negative den hartog coefficients presents trend increase progress construction second part models three representative main cables made rigid plastics using three dimension printing technology aerodynamic coefficients cables obtained wind tunnel test aerodynamic coefficients based numerical simulation wind tunnel test compared together seen experimental results relationship aerodynamic coefficients wind attack angles close corresponding numerical results result numerical simulation method paper used study galloping main cables different cross sections moreover probability galloping occurrence increases progress construction present work lays good foundation safety alerts flat topped main cables construction
building information modelling bim trend future increased use documented construction industry last years sustain momentum bim effective workforce development aims balance supply demand equation labor market essential many experience bim begins academia challenges reside classic gap academic focus disciplinary principles industry needs specific application proficiency result architecture civil engineering education needs embrace opportunities provided bim overcome challenges presented bim remain current relevant growing number architecture engineering construction programs begun offer courses include bim related content programs strategies place fully integrate paper presents modular approach adopted department civil architectural environmental engineering illinois institute technology iit promote bim enabled learning experiences creating adapting collaboration coordination learning modules bim education respectively construction management engineering graphics programs iit presented discussed content created implement facilitate learning understanding bim evaluated objective educate engineers architects future actively using bim routinely strategy relative bim learning modules expected help architecture engineering construction professionals prepared needs industry future
pervious paving pps model rigs used laboratory based experiments determine impact glyphosate containing herbicide gch ability pps retain biodegrade pollutants using three concentrations gch mgl used engine oil found hydrocarbon effluent increased time increasing gch concentration turbidity increased decreased time highest application gch declining whole unit become slightly acidic values lowest concentration gch whilst slightly higher control mirrored temporal trend highest concentration gch decreased time medium gch concentration however increased toward end monitoring period dissolution experiments appeared confirm speculation surfactant gch may forming emulsion oil facilitating release metals associated oil particulate associated pollutants possibly released aggregate may desorbed declined pps rig raises concerns receiving water quality particularly legislation encouraging use sustainable drainage systems therefore pps
monte carlo techniques widely applied check design robustness estimating production yield integrated circuits using standard random sample yield estimation large number samples required accurate verification especially high yield desired make extremely time consuming data follows normal gaussian distribution much faster yield prediction possible using well known method extended specification distance based scheme far difficult general non normal case three different means ending new generalized process capability index named gpk first apply parametric modeling specification sided distribution part way difficulties distribution parts actually little yield impact degrade model fit anymore second improve parametric model introduce new tail parameter third allow modeling difficult asymmetrical multimodal flat distributions also introduce new reference location parameter instead using mean advantage improving way opposite many enhancements like importance sampling performance gpk negatively impacted design complexity described formulation gpk derived confidence intervals using advanced bootstrap scheme verified performance sample yield representative set distributions including real production data data design cmos operational amplifier circuits
recent years lot new developments concerning use advanced materials lightweight structures examples long short fibre reinforced composites sandwiches foams last least nanostructures analysis structures made materials performed basis mechanics composites however stimulated new applications new manufacturing technologies new material compositions etc review mechanics composites necessary article actual trends discussed example developments application long short fibre reinforced composites laminates affected multifield loadings effective property based analysis foams description nanostructures within concepts continuum mechanics starting point review engineering mechanics basics level bsc program means classical strength materials extensions materials strength foundations example inclusion anisotropy often sufficient first improved estimates necessary elements continuum mechanics material testing numerical solution techniques implied every year increasing number publications field advanced materials lightweight structures allow give complete overview state art recognizing fact author give report directions related research group surrounding team
face challenges urbanization climate change morocco within initiative department water started working recently development rainwater harvesting rwh bouskoura basin pilot site selected integrated water resources management iwrm approach may considered due rapid urbanization industrialization hosting wide facilities airport highway many expanding urban areas promotion including rural areas hydrological modeling carried hec hms model reconstitution theoretical natural hydrograph lack hydrological measurements storm model study integrated effect water harvesting facilities socio economic environmental aspects basin relationships environment continuous simulations made based data climate models analysis lack ground measured climate data modeling used measure impact storm water environment general hydrological cycle particular including mitigation flood magnitudes substantial drinking water costs reduction impact obtained watering green spaces artificial recharge aquifer reduction greenhouse effect gas emissions need put emphasis fact situ iwrm developed case lead creation smart spaces smart projects smart cities smart watersheds results promising show flood mitigation bouskoura basin peak flow advantages useful importance domestic use infiltration aquifer etc impacts unit airport roads administrative industrial buildings measured case conclude space urbanized impact important information carried provide future decision support system monitor sustainable urbanization development basin
report results respondent driven sampling survey among men sex men msm kampala uganda sex behavior criminalized highly stigmatized enrolled msm aged years residing greater kampala june november anonymous data collected audio computer assisted self interviews blood tested hiv antibodies cell counts viral load estimated hiv prevalence confidence interval increasing age one five stated knowing hiv positive status similar proportion hiv infected msm virally suppressed hiv related risk behaviors included unprotected anal sex last sex act selling sex multiple steady casual partners ever injecting drugs forty percent experienced homophobic abuse ever experienced suicide ideation hiv prevalence among msm remains high whereas knowledge seropositive status suppression viral load remains low msm report wide range high risk behaviors frequent homophobic abuse poor mental health well low levels testing treatment better access tailored prevention treatment services improve population level viral load suppression warranted
computer aided learning currently applied improving educational methods order reach teaching objectives experimental fields continuous renovation process handling new machines learning usually carried teaching centres high economical inversion required furthermore number students number machines ratio high acquires special relevance technical studies practical learning essential work virtual learning training application cnc lathe presented virtual learning environment developed manufacturing engineering labs university cadiz
experimental testing unmanned surface vehicle usv performed evaluate performance two lowlevel controllers displacement drag properties time varying uncertain theusv long wave adaptive modular vessel wam inflatable twin hull configuration waterjet propulsion open loop maneuvering tests conducted characterize dynamics vehicle hydrodynamic coefficients vehicle determined system identification maneuvering data used simulations control system development resulting controllers experimentally field tested water variable mass drag tests show vehicle best controlled model reference adaptive backstepping speed heading controller backstepping controller developed liao modified account overprediction necessary control action motor saturation shown adaptive algorithm implemented surge control subsystem modified backstepping controller effects variable mass drag mitigated
background diabetes known risk factor early postoperative complications even incidence acute postoperative complications following routine hernia surgery seldom described risk reoperation recurrence hardly studied aim explore diabetes significant risk factor complications inguinal hernia surgery methods inguinal hernia repairs registered swedish hernia register identified information comorbidity postoperative complications obtained cross referencing national patient register national board health welfare complicated diabetes defined diabetes secondary manifestations corresponding adcsi hazards postoperative complications reoperation recurrence index hernia operation calculated results altogether inguinal hernia repairs patients registered number patients diabetes including patients complicated diabetes adcsi significantly increased risk postoperative complications observed days hernia surgery adjusted gender age bmi history liver disease kidney disease hiv aids type hernia surgical method odds ratio confidence interval significantly increased risk reoperation december observed either patient group conclusion diabetes seems increase risk postoperative complications within days inguinal hernia surgery especially complicated diabetes diabetes seem increase long term risk reoperation recurrence
wide range health benefits ascribed soya intake including lowered risk osteoporosis heart disease breast cancer menopausal symptoms hormonally active diet however soya also endocrine disrupting suggesting intake potential cause adverse health effects certain circumstances particularly exposure occurs development consequently question whether soya phyto oestrogens beneficial harmful human health neither straightforward universally applicable groups possible benefits risks depend age health status even presence absence specific gut microflora global consumption increases greater awareness consideration endocrine disrupting properties soya nutrition specialists health practitioners needed consumption infants small children particular concern hormone sensitive organs including brain reproductive system still undergoing sexual differentiation maturation thus susceptibility endocrine disrupting activities soya phyto oestrogens may especially high oestrogen receptor partial agonists molecular cellular properties similar anthropogenic endocrine disruptors bisphenol soya phyto oestrogens provide interesting model attitudes synthetic natural shapes understanding perception means compound endocrine disrupting potentially harmful review describes endocrine disrupting properties soya phyto oestrogens focus neuroendocrine development behaviour
allegations sexual abuse made former bbc entertainer jimmy savile former pupils girls residential school attracted worldwide publicity reported programme savile case major political cultural reverberations establishment official inquiries across countries investigate claims historical abuse responses reinforce become default position respect allegations historical abuse believe telling stories article presents case study introduces caution regard accounts past constructed particular social cultural contexts regarded necessarily reflecting wider objective reality moreover unquestioning belief may posited giving voice former care home residents may mask another politics voice within views appropriated powerful cultural elites situation implications claim abuse accused abuse natural social justice article begins address ethical issues raised professionals encounter stories historical abuse
comparative life cycle assessment methanol hydrogen electric vehicles conducted investigate impacts alternative vehicles environment human health case processes analyzed extraction raw materials hydrogen methanol electricity disposal vehicles three different environmental impact categories selected order understand diverse effects vehicles namely global warming human toxicity ozone layer depletion alternative fuel internal combustion engines hydrogen methanol directly utilized internal combustion engine vehicles results study show electric vehicles yield higher human toxicity values due respective manufacturing maintenance stages since energy density hydrogen quite higher methanol hydrogen driven vehicles result environmentally benign option respect global warming ozone layer depletion potentials hydrogen energy publications llc published elsevier ltd rights reserved
electrical generator maintenance scheduling problem tackled variety traditional optimisation techniques years paper proposes method solve maintenance scheduling problem called parallel operating cultural algorithm parca proposed model variety selection mechanisms operators communication methods local search procedures applied solution generated genetic operators parameters explained sequel cultural algorithm framework combines weak search method knowledge representation scheme collecting reasoning knowledge individual experience imacs published elsevier science rights reserved
food related parenting behaviors potential impact youth eating behaviors nutrition knowledge present study examined associations parental behaviors specific eating rules solicitation creation health focused home environment specific unhealthy eating behaviors prevalent adolescence additional analyses examined whether associations explained adolescent nutrition knowledge total adolescents years mothers years completed questionnaires part larger study investigating parent adolescent communication mothers food related parenting behaviors directly associated adolescents engagement unhealthy eating behaviors however parental rules associated greater adolescent nutrition knowledge addition mothers creation health focused home environment indirectly associated less fast food consumption greater adolescent nutrition knowledge implications future directions discussed
background ovarian reserve testing serum anti mullerian hormone amh provide information woman fertility potential aim study assess interest knowledge testing investigate utility measuring amh women reproductive age deferring pregnancy methods women ages years currently delaying childbearing invited take survey regarding attitudes knowledge testing amh measurement explanation results results women took pre test survey believed testing beneficial median amh women underwent testing iqr nineteen percent women amh percentile age undetectable amh although women using hormonal contraception none known risk factors diminished ovarian reserve seventy eight percent women low amh levels age planned seek fertility preservation pregnancy amh levels within established age normograms reassured post test survey reported benefit knowing amh level follow testing months initial measurement showed stable amh levels participants conclusions women interested testing women reassured knowing amh level whereas lower amh counseled fertility preservation options may attempt pregnancy earlier
using computerized symbolic computation technique based improved jacobi elliptic function method find several solutions whitham broer kaup like wbkl system solutions contain hyperbolic triangular solutions parameters taken special values solitary wave solutions obtained systems traveling wave solutions also discussed obtains solitary wave singular soliton solution
background clinical criteria cluster headache included chapter international classification headache disorders beta edition ichd iii may sometimes secondary pathologies case reports report two patients clinical features initially fulfilled ichd iii criteria later presented radical modifications headache natural history result secondary pathology first case secondary pontine cavernous angioma second cerebral venous thrombosis conclusion highlight importance clinical modifications could suggest clinical investigations performed repeated exclude secondary pathology previously diagnosed cluster headache pathological mechanisms brain lesions discussed
recent studies provided evidence impact social relations preschool children sharing behavior children shown generous towards friends nonfriends strangers evidence comes largely studies western children little known cross cultural differences commonalities pattern show preschool elementary school aged ugandan children show high levels generosity independent social relationships recipient finding points societal differences early sharing results discussed terms formative impact cultural traditions early development sharing preschool years
paper explores emergence joint problem solving online environments participants work together different times different places collaborations sort referred loosely coupled collaborations focus venue virtual substitute physical copresence conditions venue fundamentally social construct functions localize participation dynamics communication register creation sharing domain objects situation dependent knowledge within venue reflective parts joint problem solving become prominent within venue small teams students align views coordinate efforts share understanding work jointly problem solve
recently popularity green chemistry chemical process increased approach must comprehensively considered principles design synthesis method chemical analysis chemical process utilization nontoxic chemicals environment friendly solvents renewable materials important issues green synthesis methods importance green synthesis arises production graphene nanocomposites due future potential applications nanomedicine materials engineering herein simple approach synthesizing graphene nanocomposite using sodium citrate reducing agent sonochemical method reported synthesized agigraphene nanocomposite characterized ray diffraction xrd transmission electron microscopy tem scanning electron microscopy sem energy dispersive ray spectroscopy edx fourier transform infrared spectroscopy ray photoelectron spectroscopy xps visible spectroscopy results showed graphend oxide successfully reduced graphene silver ions silver nanoparticles sodium citrate spherical nanoparticles mean particle size approximately graphene sheets synthesized sonochemically use sodium citrate environment friendly reducing agent provided green attributes whereas use sonochemical processes synthesis method provided economic attributes study results obtained demonstrate method applicable synthesis metals graphene sheets may possibly find various forthcoming medicinal industrial technological applications elsevier rights reserved
new pathological elements voltage mirror current mirror shown advantages analog behavioral modeling circuit synthesis recently floating mirror elements used derive pathological sections ideally represent various popular analog signal processing properties involve differential multiple single ended signals order take advantage symbolic nodal analysis nullor mirror networks present nullor equivalents differential voltage cell differential voltage conveying cell current replication cell paper proposed nullor equivalents used represent many popular active devices performing symbolic two representative filter circuits containing differential characteristics active devices given verify feasibility expect used within analog design automation environment enhance circuit analysis modeling
world population corresponding million individuals infected hepatitis virus hcv small single stranded rna virus prevalence hcv infection among dialysis patients japan europe north america period found dopps study nosocomial hcv spread hemodialysis facilities still occurs increased hepatic tissue iron shown play deleterious role course hepatitis favor development fibrosis cirrhosis possibly increase risk liver cancer general population regular loss blood hemodialysis circuit routine blood sampling laboratory tests uremia monitoring gut due uremic enteropathy invariably results iron deficiency patients commonly treated intravenous iron preparations data effects iron hemodialysis patients hepatitis limited studies strongly suggest parenteral iron may contribute hepatocellular injury iatrogenic iron overload extremely prevalent among hemodialysis population worldwide iron overload toxicity emerged one controversial topic management anemia dialysis patients given known impact iron promoting growth virulence hcv associated liver disease necessary use iron therapy cautiously closely monitor plasma markers iron metabolism liver iron stores non invasively means mri avoid iron overload vulnerable population
episodic memory involves flexible retrieval processes allow link together distinct episodes make novel inferences across overlapping events recombine elements past experiences imagining future events however flexible retrieval recombination processes underpin adaptive functions may also leave memory prone error distortion source misattributions details one event mistakenly attributed another related event determine whether recombination related retrieval mechanism supports successful inference source memory errors developed modified version associative inference paradigm participants encoded everyday scenes comprised people objects contextual details scenes contained overlapping elements could later linked support novel inferential retrieval regarding elements appeared together previously critical experimental manipulation concerned whether contextual details probed associative inference test thereby allowing assess whether false memories increased successful versus unsuccessful inferences effects specific compared participants received inference test experiments used variants paradigm participants susceptible false memories contextual details successful unsuccessful inferential retrieval contextual details probed associative inference test results suggest retrieval mediated recombination mechanism underlies associative inference also contributes source misattributions result combining elements distinct episodes
previous investigation found ginkgo extract egb could attenuate depressive like behaviours induced single injection lipopolysaccharide mice however investigated whether egb effective depressive like behaviours induced long term light deprivation whether effects associated inhibition kappa signalling pathway study three groups vehicle group egb low dose group egb high dose group cbl male mice exposed constant darkness four weeks control mice remained light dark cycle depressive like behaviours evaluated tail suspension test tst forced swim test fst sucrose preference test spt spontaneous locomotor activity evaluated open field test oft levels fil mrna kappa phospho kappa kappa alpha phospho kappa alpha measured using elisa western blotting pcr assays kappa dna binding activity evaluated using chemi transcription factor assay kit results showed long term light deprivation prolonged immobile time tst fst shortened latency immobility fst reduced spontaneous locomotor activity oft decreased sucrose preference spt increased levels mrna kappa phospho kappa phospho kappa alpha hippocampal tissue egb dose dependently reversed changes parameters induced long term light deprivation without affecting spontaneous locomotor activity conclude egb could attenuate depressive like behaviours inhibit kappa signalling pathway light deprivation induced mouse model depression
environmental noise control offered undergraduate students whose major environmental engineering let students know basic knowledge control technologies noise pollution solve related problems one main special courses requires constructed keep date currents noise control technologies paper analyzed current conditions course addition described construction process effects including adjustment content improvement methods revision mode compiling databases performance experiments noise control
letter report patterning colloidal nanocrystal films combines direct beam electron beam writing cation exchange beam irradiation causes cross linking ligand molecules present nanocrystal surface cross linked molecules act mask processing consequently following step cation exchange performed directly dipping substrate solution containing new cations regions exposed electron beam chemically transformed exposed ones remain unchanged selective protection allows design patterns formed chemically different nanocrystals yet homogeneous nanocrystal film spatially resolved compositional analysis energy dispersive ray spectroscopy eds corroborates selective exchange occurs nonirradiated regions demonstrate utility lithography approach fabricating conductive wires luminescent patterns cdse cds nanocrystal films converting nonirradiated regions xse furthermore show ray irradiation lead protection cation exchange
objectivesto determine whether racial ethnicity group differences resources enhancing alzheimer caregiver health reach intervention delivery designrandomized controlled trial settingcommunity based intervention delivered five sites across united states participantsfamily caregivers persons dementia randomized active intervention condition interventionnine home sessions minutes three telephone sessions minutes intended delivered designed reduce caregiver burden depression improve caregiver self care social support help caregivers manage behavior problems persons dementia measurementsinterventionists recorded type intervention home telephone start stop times whether specific intervention content modules stress management social support administered session resultsoverall reach intervention delivery high randomized caregivers completing least five home sessions receiving eight hours intervention contact black caregivers completed fewer home sessions mean hispanics mean whites mean received less total intervention contact time mean minutes hispanics mean minutes whites mean minutes significant differences exposure content according race ethnicity found controlling demographic covariates conclusionblacks reach received significantly less intervention contact similar multicomponent interventions examine whether systematic differences intervention delivery across specific demographic subgroups explore implications treatment outcomes
first principles calculations employed investigate structural stability electronic properties non polar bar bar zno gan heterostructured nanofilms effects nanofilm thickness gan ratio considered found studied heterostructured nanofilms less stable corresponding pure zno film stable pure gan one exhibiting much thicker film better stability electronic band structures display two types heterostructured nanofilms semiconductors band gaps strongly depending gan ratios well thicknesses particular interest band gaps decrease firstly increase increasing gan ratio showing flexibly tunable band gaps cover wide range solar spectrum furthermore spatial charge distribution valence band maximum conduction band minimum studied calculating complex dielectric function properties optical absorption explored exploit potential application solar energy harvesting elsevier rights reserved
toll like receptors tlrs innate immune receptors mediate inflammatory response diabetes mellitus aim study evaluate association tlr tlr gene polymorphism patients type tdm diabetic foot study included subjects divided group patients tdm group patients tdm evidence group iii normal control subjects tlr tlr genotyping performed polymerase chain reaction restriction fragment length polymorphism pcr rflp technique subjects statistically significant difference distribution tlr genotypes groups well groups iii calculated risk estimation revealed tlr polymorphism conferred almost times increased risk disorders tdm statistical difference distribution tlr genotypes groups tlr gene polymorphism may considered molecular risk among patients tdm
receiver front end supporting contiguous non contiguous intra band carrier aggregation scenarios fully integrated spectrum sensor detect gap band blockers implemented cmos technology achieved using noise canceling lnta linearized otas used achieve iip improvement band filter band edge spectrum sensor detect blocker levels steps mhz mhz mhz system consumes supply
two key factors dam break modeling accuracy speed therefore high performance calculations great importance simulation dam break events study develop two dimensional hydrodynamic model based finite volume method simulate dam break flow routing process roe approximate riemann solution adopted solve interface flux grid cells accurately simulate discontinuous flow graphics processing unit gpu based parallel method openacc used realize parallel computing explicit discrete technique used solve governing equations correlation grid calculations single time step parallel dam break model easily realized adding openacc directives loop structure grid calculations analyze performance model considered pangtoupao flood storage area china using nvidia tesla card four different grid division schemes carefully studying implementation method optimization data transportation parallel algorithm speedup factor achieved acceleration better openmp method kernel computer analysis reveals models involving larger number calculations exhibit greater efficiency higher speedup rate addition openacc parallel mode good portability making easy realize parallel computation original serial model gpu based parallel computation advantages high performance easily available required hardware american society civil engineers
case report present endodontic treatment microsurgical intervention dens invaginatus affecting lateral incisor using cone beam computed tomography cbct year old woman visited diagnosis acute apical periodontitis upper right lateral incisor tooth endodontic treatment tooth carried intraoral radiography provided limited information unusual anatomy pulp chamber root canal system therefore preoperative cbct performed month recall radiograph revealed diameter lateral transparency cbct therefore repeated facilitate microsurgery treatment planning medical image processing program used demonstrate changes cbct images obtained root canal preparation conclusion endodontic treatment dens invaginatus challenging even endodontic specialists therapy sometimes requires surgical intervention currently available novel three dimensional imaging modalities may importance planning following root canal treatment cases especially unforeseen complications arise
introducing special issue safundi sequins self struggle catherine cole situates project focused two cape town beauty pageants illuminating catwalks become platforms rights contemporary south africa pageants serve sanctuaries participants claim fabulousness despite circumstances constraint prejudice inequality even danger perform
autism spectrum disorder asd encompasses complex set developmental neurological disorders characterized deficits social communication excessive repetitive behaviors recent years asd increasingly considered disease synapse one main type genetic aberration leading asd gene duplication several mouse models generated mimicking mutations studied effects mecp duplication human chromosome duplication synaptic development neural circuit wiring mouse sensory cortices showed mice carrying mecp duplication specific defects spine pruning duplication mouse model impaired spine formation results demonstrate spine pathology varies significantly autism models distinct aspects neural circuit development may targeted different asd mutations results underscore importance gene dosage normal development function brain
connection ningbo chenglang bridge project characteristics complicated structure mode large horizontal scale narrow construction yard short construction period etc bim technology applied direct construction project revit series software applied establish parametric model chenglang bridge collision inspection optimization construction scheme virtual construction complicated process disclosure etc finished independent development construction management platform control security quality progress well cost realized bridge construction management satisfactory effect project provides reference bimapplication like bridgework chenglang bridge project complicated structure mode large horizontal scale narrow construction yard short construction period former experience dominated construction method construction course uncontrollable construction result indefinite prone causing hard estimated losses method meet actual demand longer applying bim technology conduct virtual construction bridge construction course construction decrease accidents improve engineering quality meanwhile facilitate construction units coordinating construction sequence different specialties organizing advance professional squad enter site construction preparing equipment site turnover materials etc actualize informatized visualized integrated management construction yard course complicated construction procedure achieve dynamic control labor service physical resources cost construction course owners suggested application bim technology serve project construction early planning period project required constantly explore bim related techniques practice solve difficulties actual project paper adopts bim technology construct chenglang bridge realizes overall planning project explores construction management experience application bim technology full life cycle bridgework excogitates set key bimtechnologies suiting bridgework lays foundation bimapplication future bridgework
group metabotropic glutamate receptor agonists suggested potential anti psychotics least part based observation agonist appeared rescue cognitive deficits caused non competitive methyl aspartate receptor nmdar antagonists including spatial working memory deficits rodents tested ability rescue spatial working memory performance mice lack glua subunit ampa glutamate receptor encoded gria gene recently implicated schizophrenia genome wide association studies found failed rescue spatial working memory deficit gria mice rewarded alternation performance maze contrast reduce locomotor hyperactivity animals level similar controls similar pattern found dopamine receptor antagonist haloperidol amelioration spatial working memory deficit gria mice even though dose haloperidol reduced locomotor hyperactivity results contrast rescue spatial working memory models glutamatergic hypofunction using non competitive nmdar antagonists future studies determine whether group mglur agonists rescue spatial working memory deficits nmdar manipulations including genetic models pharmacological manipulations nmdar function
acute bioprosthetic valve thrombosis occur surgery sometimes cause hemodynamic instability cardiogenic shock risk factors bioprosthetic valve thrombosis hypercoagulability atrial fibrillation atrial dilatation low cardiac function lack anticoagulation therapy authors present case severe mitral stenosis due bioprosthetic valve thrombus patient diagnosed dilated phase hypertrophic cardiomyopathy underwent mitral valve replacement required venoarterial extracorporeal membrane oxygenation ecmo due extremely low cardiac output scheduled left ventricular assist device lvad implantation transesophageal echocardiographic examination lvad implantation revealed severe mitral stenosis due bioprosthetic mitral valve thrombus detected transthoracic echocardiography intensive care unit contributed low cardiac function thrombus removed unscheduled left atriotomy lvad implantation possibility bioprosthetic valve thrombosis must considered patient dependent ecmo support early transesophageal echocardiographic examination bioprosthetic valve may helpful contribute surgical decision making
hts hash type system type system designed component based high performance computing cbhpc platforms aimed reconciling portability modularity separation concerns high level abstraction high performance portability modularity properties component based systems extensively validated improving performance hpc applications hts introduces automated approach dynamically discovering loading binding parallel components tuned characteristics parallel computing platforms application execute based contextual abstraction performance components encapsulate parallel computations communication patterns data structures may tuned according features parallel computing platforms application requirements turn providing higher level abstraction parallel programming hts supports expressive approach skeleton based programming study safety properties hts using calculus component composition provided solid foundations design configuration languages safe specification deployment parallel components features hts validated three case studies exercise programming techniques behind contextual abstraction including skeletons performance tuning elsevier rights reserved
aimsthe aim study explicate processes patient choice undergo bariatric surgery made feel like medical necessity explore ways widespread societal stigmatization weight bariatric surgery shapes patient provider discourse surgery discuss patient rationalizations choice surgery backgroundsevere obesity currently highly stigmatized bariatric surgery become increasingly used option individuals seeking lose drastic amounts weight surgery however remains stigmatized across many diverse settings designthis research design centred ethnographic study bariatric surgery patients undergo surgery particular bariatric clinic american southwest methodsdata collection included repeated ethnographic interviews individuals enrolled bariatric programme past years interviews supplemented extensive participant observation starting date thematic analysis fieldnotes transcribed interviews followed resultspeople bariatric surgery weight loss may trade one type stigma another thus individuals qualify bariatric surgery based weight alone may reluctant explore surgery viable option research also shows younger women likely face effects weight related stigma impact motivations undergoing bariatric surgery conclusionstigma weight related surgery related needs addressed larger level terms policy clinical bariatric programmes
paper presents small size electric power sensor installed outlet sense power electrical appliances whose plugs inserted outlet data power consumption appliance power microcontroller unit mcu obtained electromagnetic induction method implemented without electrical work sensitivity power sensor power mcu generated appliance power sensor consumes sensor used measure power consumption existing electrical appliances
goal paper propose novel concept permanent magnet machine integrated airfoil shaped rotor perform compression action electrically driven conventional compressor systems need electric machines prime movers provide mechanical energy rotate compressor proposed novel integrated permanent magnet machine system synthesizes electric machine axial flow compressor single device convert electrical power mechanical rotational power rotor simultaneously compresses gas novel integrated design simplifies compressor system eliminating connection electric machine compressor weight volume cost savings expected feasibility proposed concept demonstrated combining principle knowledge electric machine design compressor design operating principles novel integrated machine described paper analytical design methods used study proposed integrated machine compressor possible topology variations proposed concept discussed
paper design build high performance machine presented machine comprises special six phase winding exhibits low harmonic content winding properties discussed detail design process machine shown fem used accurately compute eddy current effects permanent magnets building process shown respect special challenges finally computed results provided
citrulline potent precursor arginine exerts beneficial effect cardiovascular system via nitric oxide production migraine one popular neurovascular disorder imbalance cerebral blood flow cbf observed cortical spreading depression csd contributes mechanism migraine aura investigated effect citrulline cardiovascular changes kcl induced csd rats intravenous injection citrulline prevented decrease cbf monitored laser doppler flowmetry without affecting mean arterial pressure heart rate csd moreover citrulline attenuated propagation velocity csd induced kcl effect citrulline cbf change prevented name inhibitor synthase indomethacin inhibitor cyclooxygenase hand attenuation effect citrulline csd propagation velocity prevented name also indomethacin addition propagation velocity csd attenuated intravenous injection donor diminished odq inhibitor soluble guanylyl cyclase results suggest cyclic gmp prostanoids mediated pathway differently contribute effect citrulline maintenance cbf authors production hosting elsevier behalf japanese pharmacological society open access article license http creativecommons org licenses
work paper stems insight recent research efforts open vehicle routing ovr problems active area operations research based similar assumptions constraints compared sensor networks therefore may feasible could adapt techniques way provide valuable solutions certain tricky problems wireless sensor network wsn domain demonstrate approach feasible develop one data collection protocol called edal stands energy efficient delay aware lifetime balancing data collection algorithm design edal leverages one result ovr prove problem formulation inherently hard therefore proposed centralized heuristic reduce computational overhead distributed heuristic make algorithm scalable large scale network operations also develop edal closely integrated compressive sensing emerging technique promises considerable reduction total traffic cost collecting sensor readings loose delay bounds finally systematically evaluate edal compare performance related protocols simulations hardware testbed
round globe mobile devices like smartphone pdas tablets playing essential role every person day day lives various operating systems android ios blackberry etc provides platform smart devices google android one popular user friendly open source software platform mobile devices along convenience people likely download install malicious applications developed misguide user create security gap penetrate attacker hackers inclined discover exploit new vulnerabilities bring forth latest version android paper concentrate examining understanding vulnerabilities exist android operating system also suggest metadata model gives information related terms required vulnerability assessment analyzing data extracted open source vulnerability database osvdb national vulnerability database nvd
sexual double standard sds suggests women evaluated negatively men positively engaging similar sexual behaviors according social role theory sds exists due gender role structures consequently perceived violations women sexual behavior associated sds addition gender role violations sexual behavior two additional violations gender roles exist heterosexual sexual orientation norms gender role characteristics current study aims investigate whether sds persists sexual orientation violating gender role characteristic violating targets examine three gender role violations influence evaluations others sexual behavior sample participants evaluated target individuals either female male heterosexual gay man lesbian feminine masculine sexual partners results indicate sds persists gender role violating targets exhibited differently targets violating heterosexual sexual orientation norms gender role characteristics
widely suggested women represented stem fields careers fields perceived incompatible traditionally feminine roles life goals helping others maintaining marriage family although number studies women stem examined importance communal goal helping others studies examined another communal goal maintaining romantic relationship address gap designed two part study explore impact romantic relationships relationship career goals college stem majors first survey conducted examined impact relationship status male female college stem majors life goals gender roles white although results indicated gender differences goals roles related family careers interaction effects relationship status would suggest unique negative impacts women education career goals found next subsample female stem majors white male romantic partners participated study examining investments beliefs careers family balance two findings suggest successful female stem majors may seek find partners supportive educational careers goals evidenced partners investment expectations relationship work roles overall findings indicate supportive romantic partner may positive determining factor women success stem
small wavelength utilizable range used determining optimum performance photovoltaic rectenna devices compared broad band spectrum solar heat sources limits energy conversion efficiency technologies selective emitter emissivity profile matches receiver characteristic bandwidth used improve overall efficiency energy harvesting devices paper dompares simulated experimental results design fabrication selective emitter used frequency range matrix transform method used calculate radiative properties one dimensional metal dielectric photonic structures using genetic algorithm powerful optimization tool simulated design characteristics structure adjusted minimize mean square deviation actual spectral emissivity target emissivity profile specifically paper presents compares results simulated design fabrication selective emitters composed alternating layers alo sio alo sic aluminum substrate output radiation selective emitters could used input radiation high efficiency rectenna devices
botulinum neurotoxin type bnt intrasalivary gland injections patients neurological disorders known effectively treat hypersalivation however oral health compromised increasing dose aim study find therapeutic effect low dose ultrasonography controlled bnt injections bilateral parotid submandibular glands oral health treatment sialorrhea twenty patients diagnosed parkinson disease amyotrophic lateral sclerosis als neurological disorders including stroke birth trauma received bnt injections salivary tests month injections drooling evaluated using subjective scales objective assessment salivary flow rate oral health salivary composition cariogenic bacterial counts significant decrease found salivary flow rate month follow bnt treated group significant change salivary composition cariogenic bacterial counts bnt injections according current protocol effectively manage sialorrhea maintaining oral health oral health considered mirror general human health cause many diseases saliva plays crucial role protecting oral cavity present study high clinical relevance although earlier research proved effect botulinum neurotoxin type injections reduction saliva flow data risks treatment method oral condition affecting saliva composition far missing
paper develops demand hydrogen generation system produce hydrogen sodium borohydride nabh solution operate proton exchange membrane fuel cell pemfc first build hydrogen generation system hydrolyzes nabh batch reactor provide continuous supply hydrogen drive pemfc also discuss impacts solution concentration batch volume addition develop simulation model evaluates hydrogen generation temperature responses system furthermore design control strategy adjust batch intervals nabh solution according pemfc loads implement designed control microcontroller integrate pemfc experimental verification results confirm developed demand hydrogen generation system hydrolyze nabh conversion rate continuously supplies hydrogen drive pemfc copyright hydrogen energy publications llc published elsevier ltd rights reserved
design previously shown ifn alpha stimulation augments direct natural killer cell lysis autologous primary cells infected certain hiv isolates based upon major histocompatibility complex class mhc downregulation capacity investigated antibody dependent cellular cytotoxicity adcc could trigger lysis hiv isolates resistant direct lysis ifn alpha prestimulation cells could enhance adcc methods using broadly neutralizing monoclonal antibodies vrc pgv plasma hiv infected patients art suppressed elite controller trigger adcc measured cell chromium release cytotoxicity hiv infected autologous primary cells cell cda degranulation coated cells total depleted peripheral blood mononuclear cells used effectors presence absence ifn alpha prestimulation results plasma hiv infected patients monoclonal antibodies could trigger dependent adcc lysis viral isolates resistant direct cell lysis following ifn alpha stimulation contrast viral isolates exhibited potent mhc downregulation capacity could lysed cells either ifn alpha stimulated direct cytotoxicity adcc utilized combination ifn alpha prestimulation significantly augmented adcc lysis hiv infected target cells increased cell cda degranulation coated adcc targets conclusion hiv isolates lower mhc downregulation capacity resistant direct lysis following ifn alpha stimulation retain sensitivity adcc ifn alpha prestimulation significantly increase mediated clearance hiv infected target cells adcc direct cytotoxicity depending mhc downregulation status copyright wolters kluwer health inc rights reserved
prenatal development human brain undifferentiated neuroepithelium crosses numerous steps towards primordial organization subsequent cytoarchitectural layering ascending progressive lower cortical layers superior ones study represents systematic comparative assessment imaging studies histological evaluation prenatal development human brain evaluated cases using ultrasound histological study performed cases aged weeks pregnancy compared imaging results ultrasound study chose five anatomical landmarks choroid plexus thalamus cerebellum hippocampus island sylvian fissure histological study performed dissected brain specimens preserved formaldehyde followed immunohistochemical determination order complete picture morphological evolution structures evaluated analyzed accuracy description marker elements choroid plexus thalamus cerebellum hippocampus sylvian fissure three dimensional ultrasound evaluation showed good correlation morphological evaluation well dimensional descriptions literature histological immunohistochemical assessment helped complete picture central nervous system development highlighting fetal cerebral structures three dimensional ultrasound together morphological examination helped create dynamic array central nervous system development
paper propose identification framework determine copyright infringement form illegally distributed print scan books large database framework contains following main stages image pre processing feature vector extraction clustering indexing hierarchical search image pre processing stage provides methods alleviating distortions induced scanner digital camera preprocessed image propose generate feature vectors robust distortion enhance clustering performance large database use clustering method based parallel distributed computing hadobp mapreduce addition store clustered feature vectors efficiently minimize searching time investigate inverted index fedture vectors finally implement two step hierarchical search achieve fast accurate line identification simulation proposed identification framework shows accurate robust presence print scan distortions processing time analysis parallel computing environment gives extensibility proposed framework massive data matching performance analysis empirically theoretically find terms query time optimal number clusters scales root print scan books elsevier inc rights reserved
objective conduct initial validation mental health provider stigma inventory mhpsi mhpsi assesses stigma within service provider client relationship three domainsnamely attitudes behaviors coworker influence methods initial validation mhpsi conducted sample mental health employees graduate student counseling interns scale conceptualization development content validation construct validation measures discussed results preliminary psychometrics indicated good model fit three factor multidimensional scale reliabilities strong coefficient ranged global stratified evidence construct validity supported hypotheses accuracy underlying constructs conclusions mhpsi appears reliable valid measure mental health provider stigma social workers comprise front lines mental health service provision mhpsi may valuable tool guiding agency trainings social work education
china become world largest paper paperboard producer however pulp paper industry involved high resource consumption severe pollution especially water research assessed eco efficiency china pulp paper industry national level provincial level overview regarding cleaner production china pulp paper industry presented reveal measures reducing environmental impact last two decades slacks based measure used analyze efficiency levels provinces pulp paper industries uncover underlying causes eco efficiency performance malmquist luenberger index calculated discover drivers productivity growth pulp paper industries results showed pollution treatment china pulp paper industry made progress terms water consumption water pollution although absolute amount pollution discharge still large chemical oxygen demand emissions still first critical influencing factor pulp paper industry inefficiency furthermore efficiency progress dominating contribution industry productivity growth policies adjusting industrial structure pulp paper industry resulted scale effects eliminating backward production capacity accelerating merger acquisitions moreover productivity pulp paper industry underestimated undesirable outputs ignored indicates stricter environmental regulations positive effects paper companies internalize environmental pressures production activities environmental management future pulp paper companies internalize cost pollution treatment scale effects technology improvement elsevier ltd rights reserved
new topology single phase two stage sepic converter step configuration high efficiency extremely low voltage gain proposed high input power factor low input current total harmonic distortion work proposal given modify conventional two stage sepic converter introducing switched capacitor branch stages input current thd kept low input power factor high two loop feedback control proposed schemes used application battery charging electric motor vehicles
local resection stomach ideal method preventing postoperative symptoms various procedures performing local resection laparoscopic lesion lifting method non touch lesion lifting method endoscopic full thickness resection laparoscopic endoscopic cooperative surgery invention widespread use endoscopic submucosal dissection local resection become outdated curative surgical technique gastric cancer nevertheless local resection stomach treatment gastric cancer expected make comeback clinical use sentinel node navigation surgery however many issues associated local resection gastric cancer normal indications include gastric deformation functional impairment ensuring safe surgical margin possibility inducing peritoneal dissemination associated increase risk metachronous gastric cancer view issues tendency regard local resection investigative treatment applied carefully selected cases ideal model local resection stomach gastric cancer would combination endoscopic full thickness resection stomach using esd device hand sutured closure using laparoscope surgical robot achieving oncological safety preserved functions
background evidence based guidelines recommend strategies reducing risk factors secondary prevention acute coronary syndromes yet referral completion programs deliver advice poor purpose article describe complexity factors influence referral delivery evidence based cardiac rehabilitation programs australian context provide direction solutions clinicians policy makers consider ecological approach used framework synthesize evidence approach categories characteristics may act barriers enablers promotion adoption health behaviors includes interpersonal factors interpersonal factors institutional factors community networks public policy conclusions despite context strong evidence efficacy review highlights systematic flaws implementation important intervention shown improve patient outcomes prevent cardiac events recommendations review include standardization program delivery improvement data capture use technological innovations social networks facilitate delivery information support establishment cohesive consistent message interorganizational collaboration involved clinical implications avenues provide direction potential solutions improve uptake secondary prevention
experimental ooplasmic transplantation donor recipient oocyte took place saint barnabas medical center usa indication patients repeated implantation failure thirteen couples babies one patient delivered twins mixed ooplasmic donor egg embryos limited survey based follow study children reported parents completed questionnaire pregnancy birth health academic performance disclosure parents quadruplet participate prenatal development delivery uneventful school grades ranged good excellent children good health body mass index bmi normal children one child chronic migraine headaches two mild asthma three minor vision three minor skin problems one boy boy girl twin diagnosed borderline pervasive developmental disorder otherwise specified age months later symptoms one couple disclosed use egg donor child one reported intention disclose six undecided four reported would disclose limited follow strategy presents high risk bias parents may assent standardized clinical analysis owing lack disclosure children authors published elsevier ltd behalf reproductive healthcare ltd
besides genetic abnormalities mpn patients several studies reported alterations protein expression could contribute towards clinical phenotype however little known protein modifications mpn erythrocytes context used quantitative mass spectrometry proteomics approach study mpn erythrocyte proteome ltq orbitrap analysis led identification overexpressed proteins polycythemia vera essential thrombocythemia respectively compared controls functional comparison using pathway analysis software showed rho gtpase family signaling pathways deregulated mpn patients particular iqgap significantly overexpressed mpns compared controls additionally western blot analysis confirmed iqgap overexpression also showed iqgap levels depended patient genotype moreover found jakvf patients iqgap could bind rhoa rac cdc consequently recruit activated gtp rac cytoskeleton motility protein pak calr patients iqgap overexpressed immunoprecipitated rhogdi jakvf transduced cells confirmed jak inhibitor sensitive overexpression iqgap pak altogether data demonstrated alterations iqgap rho gtpase signaling mpn erythrocytes dependent jaic calr status reinforcing hypothesis modifications erythrocyte signaling pathways participate mpn pathogenesis elsevier rights reserved
background relationship bipolar disorder borderline personality disorder bpd controversial widely debated specifically comorbidity disorders yielded plethora research comprehensive reviews issue objective determine empirical evidence regarding comorbidity bpd based prevalence data explanatory theories occurrence clinical impact one disorder method comprehensive search databases pubmed psycinfo performed published manuscripts january august identified overall studies fulfilled inclusion criteria results fifth subjects showed comorbidity bpd empirical evidence common underlying factors inconclusive bpd appears risk factor data also indicated negative impact bpd suicidality worse mood course greater vice verse conclusions given high prevalence comorbidity bpd negative effects bpd subjects studies needed clarify factor associated comorbidity two disorders information important develop appropriate treatments subjects disorders improve clinical course prevent increased risk suicidality commonly found subjects elsevier rights reserved
evidence effects playing violent video games subsequent aggression mixed study examined playing violent video game affected levels aggression displayed laboratory total undergraduate students men women randomly assigned play either violent mortal kombat nonviolent pga tournament golf video game min competed confederate reaction time task allowed provocation retaliation punishment levels set participants opponents served measure aggression results confirmed hypothesis playing violent game would result aggression would playing nonviolent game addition game sex interaction showed effect larger men women findings discussed light potential differences aggressive style men women elsevier science usa
develop prediction model first recurrence child maltreatment within first year initial report carried historical cohort study using administrative data incident cases child maltreatment physical abuse psychological abuse neglect receiving support services reported april march shiga central child guidance center japan total items related characteristics child maltreatment offender household related factors selected predictive variables analyzed multivariate logistic regression model association first recurrence maltreatment according stepwise selection procedure six factors identified include year age child aor year age offender aor offender history maltreatment childhood aor household financial instability poverty aor absence someone community could watch child aor organization referral source aor using six predictors generated linear prediction model sensitivity specificity respectively model may useful assess risk maltreatment help child family welfare administrations develop preventive strategies recurrence author published elsevier ltd
used moving opportunity mto housing experiment inform housing choice vouchers housing mobility policies assist families living high poverty areas make opportunity moves higher quality neighborhoods across wide range neighborhood attributes compared neighborhood attainment three randomly assigned mto treatment groups low poverty voucher section voucher control group locations years baseline using survey reports linking residential histories numerous different administrative population based data sets compared controls families low poverty section groups experienced substantial improvements neighborhood conditions across diverse measures including economic conditions social systems collective efficacy physical features environment tree cover health outcomes low poverty voucher group moreover achieved better neighborhood attainment compared section treatment effects largest new york new york los angeles california discuss implications findings expanding affordable housing policy
control sensorless type brushless bldc motors various back electromotive force emf detecting methods widely used research finite elements method fem model pole slot bldc motor two kinds phase voltage sensing back emf detecting electrical circuits coupled achieve improved reliable analysis results coupled analysis becomes possible analyze characteristics motor electrical circuit affects motor time makes possible design high performance embedded motor controllers future experimental evaluation coupled analysis results also implemented verify coupled analysis
novel weak capacitance measurement system proposed measure gas solid two phase flows system mainly consist capacitance sensor micro programmed control unit mcu direct digital synthesizer dds operational amplifier analogue multiplier low pass filter since stray capacitance much larger variation measured capacitance stray capacitance eliminate measurement system experimental results show system meets application requirement good linearity high measurement accuracy stray immune result percentage error non linear error less sampling rate related frequency signal generator mcu clock reach kps
present work dynamic behavior inertial fibers suspended turbulent vertical channel flow investigated three dimensional turbulent flow field obtained navier stokes equations means direct numerical simulation eulerian reference frame fibers modeled prolate spheroidal particles lagrangian frame characterized inertia shape translation rotation individual fibers governed viscous forces torques well gravity buoyancy according newton laws motion test matrix comprised four different stokes numbers inertia three different aspect ratios shape twelve different fiber types suspended downward upward channel flow fiber orientation velocity statistics compared channel flow results absence gravity results showed gravity negligible effect fibers modest inertia low stokes numbers whereas gravity turned major impact dynamics highly inertial fibers irrespective bulk flow direction preferential alignment inertial fibers gravity force found channel center fibers known orient randomly absence gravity downward channel flow drift velocity fibers towards walls substantially higher fibers spheres also higher gravity neglected upward flow configuration modest drift velocity inertial spheres totally quenched fibers irrespective shape suppressed drift velocity resulted uniform fiber distribution throughout channel compared distinct near wall accumulation downward flow absence gravity suggests upward flow configuration preferred choice uniform fiber distribution desired biomass combustion reactor elsevier ltd rights reserved
generalized additive mixed models introduced extension generalized linear mixed model makes possible deal temporal autocorrelational structure experimental data autocorrelational structure likely consequence learning fatigue ebb flow attention within experiment human factor unlike molecules plots barley subjects psycholinguistic experiments intelligent beings depend survival constant adaptation environment including environment experiment three data sets illustrate human factor may interact predictors interest factorial metric also show especially within framework generalized additive model nonlinear world fitting maximally complex models take every possible contingency account illadvised modeling strategy alternative modeling strategies discussed confirmatory exploratory data analysis elsevier inc rights reserved
introduction last years viscoelastic point care poc coagulation devices thromboelastography teg rotational thromboelastometry rotem sonoclot son analyzer increasingly used major surgeries timely assessment management coagulopathies aim present study evaluate coagulation profile cyanotic cardiac patients teg rotem son analyzer addition assessed correlation standard laboratory coagulation tests postoperative chest drain output cdo parameters poc testing devices materials methods thirty five patients either gender belonging american society anesthesiologists grade iuiii undergoing elective cardiac surgery cardiopulmonary bypass cyanotic congenital heart disease included study identify possible coagulation abnormalities blood samples teg rotem son standard laboratory coagulation collected induction anesthesia correlations variables assessed using pearson correlation coefficient considered statistically significant results discussion extem clot time clot formation time cft prolonged patients whereas intem cft prolonged patients respectively fibtem maximum clot firmness mcf decreased patients observed significant correlation fibrinogen concentration rotem fibtem mcf son platelet function son showed good correlation platelet count also found significant correlation preoperative fibtem mcf cdo first postoperative hours postoperative hours receiver operating characteristic analysis demonstrated son teg maximum amplitude highly predictive thrombocytopenia area curve auc respectively fibtem mcf highly predictive hypofibrinogenemia fibrinogen auc conclusion cyanotic cardiac patients preoperative coagulation abnormalities rotem teg son parameters rotem fibtem highly predictive hypofibrinogenemia son highly predictive thrombocytopenia rotem fibtem studied marker increased postoperative cdo
background date many epidemiologic studies examining associations obesity dietary sedentary physical activity behaviors focused assessing body mass index bmi one point time recent developments statistical techniques make possible study potential heterogeneity development bmi childhood identifying distinct subpopulations characterized distinct developmental trajectories using latent class growth mixture modelling lcgmm techniques aimed identify bmi trajectories childhood examine associations distinct trajectories dietary sedentary physical activity behaviors methods longitudinal study explored bmi standard deviation score sds trajectories sample children years age information children health related behaviors obtained parental questionnaires children height weight measured associations behaviors investigated logistic regression models results identified two bmi sds trajectories decreasing bmi sds trajectory increasing bmi sds trajectory increasing bmi sds trajectory consisted participants lower socio economic status ses non western ethnicity maternal overweight status associated increasing bmi sds trajectory baseline follow six years later odds ratio confidence interval increasing bmi sds trajectory associated following behaviors drinking sugared drinks glasses per day participation organized sports per day though participation organized sports follow significant result conclusions results indicate importance healthy lifestyle behaviors young age indicate maternal bmi important risk factor development childhood overweight comprehension heterogeneity development bmi associations modifiable health related behaviors interesting prevention targeting high risk behaviors early childhood especially low ses children children non western ethnicity children whose mother overweight
purpose review number recent studies explored possibility apply personalized medicine interstitial lung diseases ilds particularly idiopathic pulmonary fibrosis ipf common deadly idiopathic interstitial pneumonias review summarize discuss recent literature personalized medicine ipf well hypersensitivity pneumonitis sarcoidosis emphasis patient subgroups personalized approach disease prognostication management may become reality near future recent findings studies explored applicability personalized medicine ilds conducted patients ipf studies suggested existence several distinct disease subgroups defined similar genetic profiles molecular pathways exposures individual lifestyles personalized medicine hypersensitivity pneumonitis infancy development applicability personalized medicine sarcoidosis hand remains problematic several reasons including lack diagnostic gold standard highly variable unpredictable disease course particularly across patients different ethnicities poor correlation disease activity disease severity lack validated management algorithm summary number distinct patient subgroups identified ilds although available data need validated longitudinally possibility study homogeneous groups patients may allow prediction disease behavior response treatment dramatic clinical implications
background aims recent opioid epidemic prompted renewed interest opioid use disorder treatment little evidence regarding health related quality life hrqol outcomes treatment programs measuring hrqol represents opportunity consider outcomes opioid use disorder treatment patient centered relevant overall health abstinence alone conducted systematic literature review explore extent collection hrqol opioid treatment programs documented treatment program literature materials methods searched pubmed embase psycinfo web science papers published reported hrqol outcome measures substance abuse treatment programs results unduplicated articles initially identified screening articles met criteria review articles unavailable english therefore articles reviewed articles included quality life measure included validated hrqol measures supported derivation quality adjusted life year utility weights frequently used validated measure addiction severity index asi non recent studies likely include measure hrqol conclusions hrqol measures rarely used outcomes opioid treatment programs field incorporate hrqol measures standard practice especially measures used derive utility weights instruments provide policy makers evidence impact programs patients lives data quantify value investing opioid use disorder treatments elsevier inc rights reserved
aims determine whether childhood physical abuse cpa histories associated age onset psychoactive substance use injecting extent polydrug use among injecting drug users idu design cross sectional setting sydney australia participants measurements total idu administered structured interview examining prevalence severity cpa drug use histories findings participants experienced severe abuse mild moderate abuse mma abuse history controlling variables history severe cpa significant independent correlate earlier age first alcohol intoxication compared beta mma beta groups severe cpa also significant independent correlate earlier age first illicit drug use compared beta mma beta groups contrast cpa histories independently associated onset injecting drug use controlling potential confounders mma beta beta groups associated extensive life time polydrug use differ controlling potential confounders mma beta beta group membership associated extensive recent polydrug use differ significantly conclusions severe childhood physical abuse severity associated earlier initiation drug use level abuse associated extensive life time recent polydrug use
stakeholder engagement vital sustainable remediation practice obtaining useful feedback identifying societal needs evaluating integrating risk perception stakeholders remediation outreach efforts allows greater insight increases likelihood success ultimately benefits community protecting members environmental hazards study identified risk perception factors influenced residents level concern mitigating exposure elevated concentrations lead household paint historic fill material risk perception factors assessed person survey conducted public green spaces analysis survey participants responses indicated perception risk exposed lead mostly influenced presence hazardous materials close proximity residence ability address pollution awareness interest individual accountability mitigating environmental risks responses also revealed residents considered risk lead soil pollution less menacing presence immediate perceptible risks posed factors air water pollution addition community seemed exhibit optimism bias identify high risk susceptible immediate hazards including lead exposure lack concern lead exposure created significant obstacle community participation state led education outreach programs integrating risk perception analysis increasing stakeholder engagement bring attention issue educate public threat lead pollution efficiently use financial resources implement sustainable solution published elsevier ltd
work presents novel approach decisionmaking multi objective binary classification problems purpose decision process select within set pareto optimal solutions one model minimizes structural risk generalization error new approach utilizes kind prior knowledge available allows selection model better represents problem question prior knowledge imprecisions collected data enables identification region equivalent solutions within set pareto optimal solutions results binary classification problems sets synthetic real data indicate equal better performance terms decision efficiency compared similar approaches
objective use modern high resolution inner ear imaging modalities evaluate endolymphatic hydrops patient migraine associated fluctuating hearing loss without vertigo spells dizziness background well described patients meniere disease human temporal bone studies modern high resolution imaging however study date knowledge examines presence patient migraine bilateral hearing loss present mri findings using sequence detecting unique case patient experiencing migraine headaches accompanied fluctuating hearing loss without vertigo methods magnetic resonance imaging sequences included cisternographic three dimensional delayed intravenous enhanced three dimensional fluid attenuation inversion recovery dive flair sequences performed bright perilymph bright endolymph inversion times bright endolymph images subtracted bright perilymph images create composite image bright perilymph dark endolymph intermediate bone signals results year old female presented left sided sensorineural hearing loss severe migraine headaches began age past year experienced severe migraines right sided fluctuating sensorineural hearing loss tinnitus aural fullness audiometry confirmed drop right sided hearing times migraines increased symptom severity vestibular testing within normal limits mri demonstrated presence severe bilateral vestibular cochlear conclusions cochlea vestibule present patients without meniere disease vertigo relationship migraine meniere disease may complex demonstrated patient migraine associated bilateral hearing loss mri documentation severe bilateral fact migraine associated important demonstrates potential relationship pathophysiology migraine given patient previous association migraine hearing loss age appears migrainous attacks occur simultaneously hearing loss may potentially causative fluctuating hearing loss mediated possibly development new imaging modalities allow studies field inner ear pathology significant implications future research
purposethe aim study quantify influence length look back period misclassification heart failure incidence medicare claims available participants population based cohort methodsatherosclerosis risk communities participants years continuous fee service medicare enrollment assigned index date months enrollment separating time observation period look back incidence periods incident events identified using icd code algorithms first observed hospitalization claim second two outpatient claims occurring within months using months referent look back period reduced month increments look back period calculated incidence rate percent prevalent events misclassified incident loss sample size resultswe identified atherosclerosis risk communities participants risk hospitalized outpatient number events misclassified incident increased total number incident events decreased increased length look back period incident rate per person years decreased increased length look back period months greater impact outpatient example icd hospitalization primary position outpatient conclusionour estimates used optimize trade offs degree misclassification number events estimation incident administrative claims data pertinent different study questions copyright john wiley sons ltd
primary working mechanism behind nanofluids thermal conductivity distinguished one controversial issues nanofluids several theories proposed literature nanopartides clustering sole mechanism observed even micro scale level several parameters including nanofluid preparation method particles concentration particles morphology temperature elapsed time experimentally altered investigate role nanoparticles micro clusters nanofluids thermal conductivity observed minor variation altering parameters would lead remarkable change micro clusters configuration subsequently thermal conductivity nanofluids paper focused phenomenon introducing new application image processing tool study morphological characteristics micron sized clusters approach demonstrated higher thermal conductivity obtained particles micro clusters well percolated base fluid result well diffused percolating micro structures known significant role heat conduction nanofluids elsevier ltd rights reserved
present study emphasises application dish stirling solar thermal system dsts automatic generation control agc unequal two area thermal system thermal systems equipped single reheat turbine generation rate constraint governor dead band system dynamics without dsts tested integral proportional integral proportional integral derivative three degree freedom proportional integral derivative dof pid secondary controllers simultaneous optimisation controller parameters controller done biogeography based optimisation bbo technique dof pid controllers system dsts outperform controllers terms magnitude oscillation peak deviation settling time system dynamic responses validated random load perturbation sensitivity analysis proves bbo optimised dof pid controller parameters obtained nominal conditions healthy enough optimised dof pid controller parameters necessarily needed optimise wide changes system loading inertia constant step load perturbation slp areas higher slp area integration dsts agc thermal system safely attributed
paper presents many objective optimization maoo approach design control observer gains simultaneously many objective optimization maoo approach finds trade offs different nonagreeable design goals report maoo results proportional integral derivative pid control state estimator applied second order oscillator overall system optimized minimize peak time overshoot tracking error control energy maximize rejection external disturbance measurement noise relative stability defined maximum real part eigenvalues closed loop system constrained less equal numerical simulations show promising findings proposed method
paper presents current sense amplifier csa capable performing measurements high input common mode voltages independent power supply rail proposed circuit employs fully low voltage amplifier cell correction block maintaining linearity input stage entire input protection circuit high differential input voltages diff furthermore trimming procedure enables use typical polysilicon gain resistors without losing accuracy precision discussed proposed architecture implemented standard bcd technology performances confirmed simulations measurements
paper presents analog building blocks find potential applications display panels buffer source follower subtractor adder high gain amplifier employing type enhancement amorphous gallium indium zinc oxide thin film transistors gizo tfts designed simulated fabricated characterized circuit simulations carried using neural model developed house measured characteristics transistors adder subtractor circuit presents power consumption amplifier presents gain power consumption load omega authors knowledge highest gain reported far single stage amplifier gizo tft technology
background studies small groups patients indicated splenic volume may decreased patients celiac disease refractory rcd type enteropathy associated cell lymphoma eatl objective objective article evaluate large cohort uncomplicated rcd eatl patients healthy controls methods retrospective cohort consisted uncomplicated remission rcd eatl patients rcd eatl control group included healthy living kidney donors determined computed tomography results median uncomplicated group significantly larger controls interquartile range iqr versus iqr correction body surface area age gender ratio uncomplicated versus controls confidence interval median rcd patients iqr smaller median control group conclusion study demonstrates large inter individual variation enlarged uncomplicated small rcd may clinical relevance considering immune compromised status patients
introduction examined association decreased cerebral blood flow cbf cognitive impairment alzheimer disease mild cognitive impairment mci subjective cognitive decline scd methods included mci scd patients amsterdam dementia cohort used pseudo continuous arterial spin labeling estimate whole brain regional partial volume corrected cbf neuropsychological tests covered global cognition five cognitive domains associations investigated using linear regression analyses results whole sample reduced overall regional cbf associated impairment cognitive domains found significant interactions diagnosis cbf language diagnosis parietal cbf global cognition executive functioning stratification showed decreased cbf associated worse performance patients mci scd discussion results suggest cbf may potential functional marker disease severity alzheimer association published elsevier inc rights reserved
little known regarding subsequent course non alcoholic fatty liver disease nafld diagnosed childhood objectives single center study gather data long term health outcomes assess feasibility contacting former pediatric patients large pediatric medical center electronic records searched initially identify former patients liver biopsy subjects met criteria age follow year biopsy proven nafld recruited via postal electronic mail participants invited complete brief telephone survey current health status supplemental data also obtained pediatric medical charts subjects nafld diagnosis subjects diabetes obese nash fibrosis biopsy follow subjects responded survey based survey chart review mean follow years additional subjects developed diabetes period prevalence subjects remained obese last follow additional prospective studies needed fully describe longitudinal risks associated pediatric nafld require multi dimensional strategies successfully recruit former patients
werner syndrome adult progeria rare autosomal recessive disorder caused mutations wrn gene characterized premature appearance features associated normal aging cancer predisposition patients werner syndrome present musculoskeletal complaints associated suggestive radiographic features potential prognostic therapeutic impact review illustrates main radiographic features werner syndrome focusing musculoskeletal system soft tissue calcification muscular atrophy osteoporosis foot deformities osteitis osteomyelitis bone soft tissues malignancies identification features radiologists therefore useful clinical screening werner syndrome editions franc aises radiologie published elsevier masson sas rights reserved
necessity schools implement human resources management hrm increasingly acknowledged specifically hrm holds potential increasing student outcomes increased involvement empowerment motivation teachers educational literature however little empirical attention paid ways different hrm practices could bundled comprehensive hrm system content hrm could best implemented attain positive teacher student outcomes process regarding content following amo theory performance argued hrm systems comprise ability motivation opportunity enhancing hrm practices regarding process based hrm system strength literature argued teachers perceive hrm distinctive consistent perceive consensus enhance teachers schools performance combining insights educational studies single hrm practices hrm theories paper builds conceptual framework used design hrm systems understand way operate
purpose homeless adults higher prevalence smoking compared general population tobacco cessation efforts focused general population limited attention paid vulnerable population study homeless adults well shelter staff interviewed understand attitudes beliefs smoking smoking cessation receptiveness smoking cessation interventions methods semi structured one one interviews audio recorded transcribed homeless adult smokers staff recruited homeless shelter charleston south carolina transcripts analyzed systematic manner independent investigators trained grounded theory constant comparison method used code categorize synthesize qualitative data results majority smokers interviewed expressed desire stop smoking felt stress homeless barrier quitting asked different tobacco cessation methods preferred method skepticism regarding actual effectiveness different methods since many previously unsuccessful tried smokers shelter staff acknowledged tobacco cessation important see priority shelter residents even though cessation medications available shelter clinic smokers shelter staff interviewed aware availability medications conclusions study suggests adult smokers homeless shelter interested quitting smoking receptive toward assistance lack awareness perceived importance cessation among staff significant barrier providing training staff encouraging take proactive approach tobacco cessation may area focus future cessation interventions
wireless communication systems conventional secret key exchange based public key cryptography requires complex computations retain secrecy level key bits proposed physical layer based algorithms shown promising performance extract secret keys privately shared randomness relying reciprocal channel state communicated nodes study authors propose physical layer key exchange method transmits key bits encoding within phase randomisation sequences privately indexed specific channel criterion sequences randomise data phases thus efficiency reduction incurred fact choosing pool randomisation sequences certain statistical properties could also used condition signal meet physical layer transmission requirements bandwidth envelope quantify potential proposed method demonstrating within context multiple input multiple output orthogonal frequency division multiplexing system results reveal relative existing techniques proposed method offers superior key error rate performance lower computational complexity better secrecy level
background disturbances microcirculation playa significant role development progression acute chronic cerebrovascular diseases cvd may associated different hemogram abnormalities one reasons prothrombogenic state endothelium increase number blood corpuscles leading non myeloproliferative disorders mpd including essential thrombocythemia polycythemia vera primary myelofibrosis materials methods study included patients patients mpd control group comprising patients cvd according mpd subtype patients divided three groups patients male female age years male female age years male female age years results cases study group mpd patients chronic cvd frequently identified symptoms asthenia headache headache mpd patients frequently associated patients equally distributed neurological symptoms cases associated focal changes brain mri localized subcortical area frontal parietal lobes twenty one patients suffered acute cerebrovascular accident thrombotic occlusion one internal carotid arteries leading hemispheric infarcts endothelial function measured flow dependent dilation brachial artery severely impaired study groups median normal cut lowest degree vasodilator activity specific patients history stroke conclusion patients suffering mpd asymptomatic focal changes brain absence concomitant vascular disease hypertension atherosclerotic vascular disease heart rhythm disorders cases mpd remaining underdiagnosed presents major concern cerebrovascular setting large number thrombotic strokes occurring patients underline necessity early diagnostics preventive therapy patients author published karger basel
field construction indoor localization mobile construction resources remains universal challenge although discussions focused tracking accuracy affordability indoor localization technologies efforts focused practical criteria ease use latency data visualization remote sharing close gap knowledge study introduces building information modeling bim cloud enabled radio frequency identification rfid localization system system consists three main components passive rfid localization system bim visualization system cloud computing system proposed system tested full scale implementation actual construction site test designed conducted evaluate localization accuracy data latency real time data processing visualization remote monitoring comprehensive analysis made various practical issues based test results panel discussion findings study indicate bim cloud enable rfid indoor localization solution great potential practical applications site security control safety management asset management productivity monitoring
commerce applications world grown exponentially years set mobile users engage wirelessly hoc network infrastructure online business irrespective place time providing anonymous secure trust based connection service hoc network quite challenging task anonymity security privacy transaction message transmission highest priority need delivered destination node time paper caec cellular automata elliptic curve cryptography mix network algorithm secure mobile commerce hoc network proposed attempt made design mix network mix net using elliptic curve cryptography based cellular automata creates hard trace communication protect anonymity sender encrypt sensitive information avoid eavesdropper trying access data transmission caec provides also confidentiality integrity authentication
social online communities platforms play significant role activities software developers either integral part main activities complimentary knowledge information sharing techniques become prevalent resulting wealth shared information need effectively organize sift information becomes important top approaches formal hierarchical directories shown lack scalability applicable circumstanes light weight bottom techniques community tagging shown promise better organizing available content however focused communities practice software engineering development community tagging face challenges tag explosion locality tags interpretation differences name address challenges propose semantic tagging approach benefits information available wikipedia semantically ground tagging process provide methodical approach tagging social software engineering content shown approach able provide high quality tags social software engineering content used organizing content also making meaningful relevant content recommendation users within local community also across multiple social online communities empirically validated approach four main research questions results observations show proposed approach quite effective organizing social software engineering content making relevant helpful novel content recommendations software developers users social software engineering communities
manage smart electric grid future fundamental changes required system operational paradigm availability high resolution data faster speed advanced computational advancements provide opportunities bring fundamental change monitoring control algorithms need evolved match transition centralized generation distributed generation intermittency renewable generation push towards real time control requires faster control actions possible decentralized power grid applications integration distributed energy resources ders stability assessment application need handle large number data points real time requires massive computing resources requirements increase possible real time control action decentralized applications need coordinated manged existing centralized applications paper addresses development fault tolerant distributed computing architecture dcblocks implementing decentralized voltage stability monitoring control application results ieee bus system provided validate developed architecture distributed computing algorithms implemented using open source platform akka java deterlab test bed
backgroundinterventions found effective research settings often effective implemented community settings considering children autism studies rarely examined efficacy laboratory tested interventions child outcomes community settings using randomized controlled designs methodsone hundred thirteen children autism enrolled public early intervention classrooms low resource neighborhoods randomized joint attention symbolic play engagement regulation jasper intervention treatment usual waitlist weeks month follow resultsteaching assistants delivered jasper adequate fidelity children randomized jasper demonstrated significant gains treatment usual core developmental outcomes joint engagement joint attention play skills maintained follow conclusionssupervised teaching assistants delivered jasper intervention range toddlers autism leading significant gains developmental outcomes
long noncoding rnas lncrnas pervasively transcribed genome emerging molecular biology crucial regulators cancer rna seq data downloaded geo ncbi analyzed identify novel targets intrahepatic cholangiocarcinoma icca investigated differences lncrna mrna profiles pairs icca adjacent normal tissues lncrnas differentially expressed four fold change icca tissues among upregulated downregulated relatively normal tissues moreover lncrnas mrnas formed lncrna mrna expression network consist network nodes connection edges bioinformatics analysis identified dysregulated lncrnas associated cholesterol homeostasis insoluble fraction lipid binding activity enriched complement coagulation cascades ppar signaling pathway results uncovered landscape icca associated lncrnas expression network providing insightful information dysregulated lncrnas icca
campus buildings public education taiwan naturally ventilated since hot humid summer free running classrooms vulnerable overheating may impair students learning ability studied diamond certified green building campus determine effectiveness strategies adopted prevent overheating quantifying room thermal comfort via long term situ monitoring temperatures passive planning design means used case presented detail resulting synthesis effect terms relation indoor thermal comfort student learning performance also discussed maximum percentage dissatisfaction classrooms less outdoor condition severity overheating outdoors average learning performance around higher outdoor condition green building certification system eewh practiced taiwan evaluates various aspects regarding thermal comfort enhancement studied naturally ventilated school building demonstrates complying eewh credits indoor thermal quality successfully ensured elsevier ltd rights reserved
objective rare disease background intravascular lymphoma ivl rare lymphoproliferative disorder characterized proliferation large lymphoma cells within lumen small caliber blood vessels clinical features nonspecific presenting systemic disease fever may life threatening antemortem diagnosis difficult may made biopsies affected tissues random skin biopsies case report report case year old white woman presenting fever unknown origin fuo developed neurologic pulmonary hematologic manifestations diagnosis intravascular large cell lymphoma ivlbcl made random skin biopsies received treatment steroids rituximab cyclophosphamide vincristine doxorubicin chop disease evolution unfavorable died first cycle chemotherapy conclusions case illustrates ivl present fuo considered differential diagnosis syndrome especially patients neurologic compromise persistently elevated serum lactate dehydrogenase case diagnosis made cutaneous biopsies visibly unaffected skin patient course ivl usually fatal within months
whole human body kidney undergoes age related changes translate inexorable progressive decline renal function renal aging multifactorial process gender race genetic background several key mediators chronic inflammation oxidative stress renin angiotensin aldosterone raas system impairment kidney repair capacities background cardiovascular disease play significant role features aging kidney include macroscopic microscopic changes important functional adaptations none pathognomonic aging assessment renal function framework aging problematic question whether renal aging considered physiological pathological process remains much debated issue although promising dietary pharmacological approaches tested retard aging processes renal function decline elderly proper lifestyle modifications applicable general population currently represent plausible approach maintain kidney health elsevier rights reserved
paper reports part doctoral study explored stakeholder perceptions importance homelike environment care home factors contributed changes institutional care older people evolved warehouse type environment poor mad sick unloved place older people need care spend days safety homely environment environment one quality indicators care home provision yet defining homeliness means fraught difficulties article presents narrative literature review concept home common measures taken address homeliness care home setting results show although word homely used presumption shared understanding concept elusive highly subjective given long term care provides homes increasingly wide range age groups individuals increasingly diverse backgrounds personal histories shared viewpoint homeliness possible indeed ever possible make institution homely crown copyright published elsevier ireland ltd rights reserved
government govt services provide new opportunities citizens allowing use government services paying electricity bill filing ticketing get information government policies schemes etc anytime anywhere irrespective geographical location releases citizens bound government official hours experience plays important role change users intention adopt impacts behavior attitude aim study investigate citizens experience gov services experience influences behavior study also investigates users value gov services study used qualitative approach involving citizens india gov services still early stage findings highlight extent citizens moving traditional ways using government services using electronically study also takes account effect technological innovations government settings participant perspective implications researchers practitioners discussed emphasis government need develop competent gov services elsevier ltd rights reserved
objectives mild level iodine deficiency pregnancy may reduce maternal thyroid hormone production supply fetus hence affecting brain neurodevelopment aim present study investigate association elevated neonatal thyroid stimulating hormone tsh level used marker maternal mild iodine deficiency late pregnancy behavioral development preschool children methods retrospective cohort study included belgian mothers children aged years old tsh levels range birth tsh level measured dried blood spots filter paper collected heel stick days birth low birth weight prematurely born children children congenital hypothyroidism excluded degree behavioral problems evaluated using child behavior check list cbcl age years questionnaire relevant socioeconomic maternal child factors also collected results tsh concentrations cbcl scores associated univariate analysis adjusting confounding factors multivariate analysis discussion elevated tsh concentrations measured birth associated behavioral development scores
promote energy efficient operations residential office buildings non intrusive load monitoring nilm techniques proposed infer fine grained power consumption usage patterns appliances power line measurement data fine grained monitoring everyday appliances toasters coffee makers promote energy efficient building operations also provide unique insights context activities individuals current building level nilm techniques unable identify consumption characteristics relatively low load appliances whereas smart plug based solutions incur significant deployment maintenance costs paper investigate intermediate architecture smart circuit breakers provide measurements aggregate power consumption room section level granularity investigate techniques identify usage energy consumption individual appliances measurements first develop novel correlation based approach called cbpa identify individual appliances based unique transient steady state power signatures promising cbpa fails set candidate appliances large improve accuracy appliance level usage estimation propose hybrid system called aarpa uses mobile sensing first infer high level activities daily living adls uses knowledge adls effectively reduce set candidate appliances potentially contribute aggregate readings point evaluate two variants algorithm show using real life data traces gathered domestic users fusion mobile power line sensing promising identified devices used data trace identified usage duration energy consumption low load consumer appliances similar accuracy
background aim study determine reference values thyrotropin tsh thyroid hormones total free thyroxine total free triiodothyronine thyroglobulin thyroid antibodies thyroid peroxidase tpoab thyroglobulin antibody tgab population republic srpska methods total euthyroid subjects enrolled study direct method choosing reference subjects used establish reference intervals hormones thyroid antibodies measured electrochemiluminescence immunoassay method eclia roche diagnostics mannheim germany calculated erence intervals medcalc version medcalc software belgium recommended ifcc clsi results using guidelines recommended national academy clinical biochemistry nacb based standard statistical approaches reference intervals derived tsh miu pmol nmol pmol nmol tpoab tgab miu miu respe ctively found significant difference tsh values different age groups well values nder groups conclusions established reference values population republic srpska significantly different values recommended manufacturer reagents roche diagnostics results showed laboratory needs establish reference values order set proper diagnosis well treat patients successfully
background decreased endothelial function may prognostic marker stroke measuring pharmacological effects may interest development personalized medicine stroke prevention study assessed reliability repeated measurements using pulse amplitude tonometry technology acute stroke patients similarly reliability tested healthy subjects devoid vascular disease estimate reactivity reliability younger non stroke population materials methods assessed using endopat healthy volunteers men mean age years stroke patients men mean age years mean nihss standardized conditions measured reactive hyperemia index rhi logarithm rhi lnrhi framingham rhi frhi measurements separated assess day day day reliability respectively results fair moderate correlations measurements intraclass correlation coefficient icc day iccday day detected healthy subjects stroke patients found moderate substantial correlation day day day repeated measurements iccsame day iccday day frhi compared rhi lnrhi showed best reliability conclusion repeated measurements frhi stroke patients show moderate reliability day substantial day day measurements likewise healthy subjects substantial reliability day day measurement moderate day measurements general day day correlation repeated measurements far better day measurements ranged poor moderate depending specific outcome measure possible carryover effect considered day repeated testing drug effects applied future studies
multiple sclerosis cells aberrantly recognize self peptides myelin sheath attack central nervous system cns antigen specific peptide immunotherapy aims restore tolerance avoiding use non specific immunosuppressive drugs promising approach combat autoimmune disease cellular mechanisms behind successful therapy remain poorly understood myeloid derived suppressor cells mdscs studied intensively field cancer lesser extent autoimmunity suppressive effect immune system cancer hypothesized development mdscs interaction cells could beneficial antigen specific immunotherapy hence changes quantity phenotype function mdscs tolerance induction model evaluated reveal first time involvement subset mdscs known polymorphonuclear pmn mdscs process tolerance induction pmn mdscs shown adopt suppressive phenotype peptide immunotherapy inhibit cell proliferation cell contact dependent manner mediated arginase moreover increased numbers tolerogenic pmn mdscs observed course peptide immunotherapy demonstrated provide protection disease model experimental autoimmune encephalomyelitis
purpose aim study determine whether electrodiagnostic differences carpal tunnel syndrome cts patients diabetes mellitus cts hypothyroidism cts fibromyalgia syndrome cts rheumatoid arthritis idiopathic cts cases comparing nerve conduction studies methods research examined electrophysiologic studies untreated cts diabetes mellitus cts cts fibromyalgia syndrome cts idiopathic cts cases healthy control group individuals total patients hands cts results significant differences groups terms sex age significant difference cts groupsin terms numberswith mild moderate severe cts cts groups compared control group cts groups left right hands significant prolongation median motor latency median sensory latency finger also significant decrease median sensory velocity finger diabetes mellitus groups median motor amplitudes hands significantly decreased compared idiopathic group moderate significant negative correlation disease duration median motor amplitudes right left sides right left groups right left conclusions electrodiagnostic results showed demyelinating injury axonal damage diabetes mellitus patients cts patients treatment cts early treatment planning include risk factor diseases
preterm neonates susceptible gastrointestinal disorders necrotizing enterocolitis nec maternal milk colostrum protects nec via growth promoting immunomodulatory antimicrobial factors fetal enteral diet amniotic fluid contains similar components hypothesized postnatal administration reduces inflammatory responses nec preterm neonates preterm pigs gestation delivered caesarean section fed parental nutrition days followed enteral days porcine colostrum colos infant formula form supplied introduction formula experiment supplied enteral feeding period experiment form nec score reduced colos pigs relative form provided prior full enteral feeding compared effect provided enteral feeding pigs showed decreased bacterial abundance colon intestinal inflammation related genes tnf alpha alpha nos downregulated relative form pigs nec anti inflammatory properties supported delayed maturation decreased tnf alpha production murine dendritic cells well increased proliferation migration downregulation expression intestinal cells iec ipec like colostrum may reduce nec development preterm neonates suppressing proinflammatory responses enteral formula feeding gut colonization provided onset nec
propose many core gpu implementation robotic motion planning formulated semi infinite optimization program approach computes constraints gradients parallel feeds result nonlinear optimization solver running cpu ensure continuous satisfaction constraints use polynomial approximations time intervals constraint gradient evaluated independently time interval end highly parallelizable problem take advantage many core architectures classic robotic computations geometry kinematics dynamics also benefit parallel processors carefully study implementation context results full constraint evaluator running gpu present several optimization examples humanoid robot reveal substantial improvements terms computation performance compared parallel cpu version
patients inflammatory bowel disease dissociation occur symptoms presence inflammatory lesions dissociation led recognition objective measures disease activity together clinical assessment primary endpoints clinical trials objective assessment inflammatory lesions classically relied ileocolonoscopy however examination endoscopy always complete evaluate transmural changes furthermore histological alterations may persist presence mild even absent endoscopy lesions reasons cross sectional imaging particularly magnetic resonance imaging mri histology considered potential new tools objective assessment lesions patients crohn disease shown mri high degree accuracy evaluation presence severity inflammation validated indices activity magnetic resonance index activity maria responsive effective therapeutic interventions context clinical trials mri may help patient selection providing always complete assessment small bowel colon detecting presence complications generally accepted definition histological mucosal healing used clinical trials crohn disease ulcerative colitis exist several histological scoring systems available based evaluation presence neutrophils epithelial cell damage increase lymphocytes plasma cells present histological remission included primary endpoint therapeutic trials better outcomes associated achievement histological healing favours consideration histology endpoint future
introduction oxidative stress seems play critical role degeneration dopaminergic neurons parkinson disease antioxidant compounds deactivate scavenge free radical olive leaves considered useful source phenolic compounds therefore study designed investigate effects methanolic olive leaf extract ole neurobehavioral activity antioxidant enzyme activity malondialdehyde mda glutathione gsh levels striatum rats experimental model methods induced animals intrastriatal injection hydroxydopamin unilaterally animals pretreated ole body weight weeks behavioral activity narrow beam grip testes antioxidant parameters evaluated results study behavioral testes showed improvement motor coordination balance behavior rats pretreated ole furthermore extract olive leaf restored activity antioxidant enzymes superoxide dismutase glutathione peroxidase glutathione reductase catalase decreased mda increased gsh levels brain rats conclusion results suggest ole shows neuroprotective effect animal models parkinson disease
study aimed evaluate association dental students personality traits stress levels relation dental education programs among senior dental students university malaya malaysia national university singapore nus cross sectional survey using self administered questionnaire conducted nus senior dental students questionnaire comprised items demographic background big five inventory personality traits bfipt test modified dental environment stress des scale rasch analysis used convert raw data interval scores analyses done test pearson correlation hierarchical regression statistics response rate nus personality trait agreeableness mean significantly prevalent among nus students mean nus neuroticism mean significantly prevalent mean des mean score higher among nus mean students mean neuroticism significantly correlated stress levels nus neuroticism agreeableness conscientiousness personality traits correlation strongest personality trait neuroticism schools hierarchical regression analysis showed gender neuroticism significant predictors students stress levels latter exerting bigger effect size gender study showed gender neuroticism personality trait significant predictors stress levels among selected groups dental students southeast asia information students personality may useful new students intake stress management counseling future program reviews
order provide realistic basis structural damage identification safety evaluation long span bridges modal parameters kilometer scale cable stayed bridge identified using wavelet transform method sutong cable stayed bridge scb excited typhoon haikui taken research object based structural vibration responses recorded structural health monitoring system shms scb modal parameters including frequency damping ratio bridge identified using method four vertical two torsional one lateral modes selected analysis comparing analysis results related references whole process variation modal parameters scb typhoon haikui investigated furthermore relationship modal parameters wind speed analyzed results show modal parameter identification based method stable reliable influence wind speed modal frequencies small however influence modal damping ratios remarkable shows regularity increase wind speed first four vertical first torsional modal damping ratios increase first lateral second torsional modal damping ratios decrease american society civil engineers
constipation one common gastrointestinal complaints worldwide study performed determine whether bifidobacterium adolescentis exerts inter strain differences alleviating constipation induced loperamide balb mice analyze main reasons differences balb mice underwent gavage adolescentis ccfm per day days primary outcome measures included related constipation indicators secondary outcome measures basic biological characteristics strains concentration changes short chain fatty acids feces changes fecal flora adolescentis ccfm relieved constipation symptoms adhering intestinal epithelial cells growing quickly vitro increasing concentrations propionic butyric acids effect adolescentis gut microbiota mice constipation investigated via rrna metagenomic analysis results revealed relative abundance lactobacillus increased amount clostridium decreased adolescentis ccfm treatment groups conclusion adolescentis exhibits strain specific effects alleviation constipation mostly due strains growth rates adhesive capacity effects gut microbiome microenvironment
bernoulli poisson processes two popular discrete count processes however rely strict assumptions instead propose generalized homogenous count process name conwaymaxwell poisson com poisson process includes bernoulli poisson processes special cases also serves flexible mechanism describe count processes approximate data dispersion introduce process associated generalized waiting time distribution several real data applications illustrate flexibility variety data structures consider model estimation different scenarios data availability assess performance simulated real datasets new generalized process enable analysts better model count processes data dispersion exists accommodating flexible manner
lack research documenting weight making practices mixed martial arts mma competitors purpose investigation quantify magnitude identify methods rapid weight loss rwl rapid weight gain rwg mma athletes preparing competition seven athletes mean age yrs body mass competitive experience yrs participated repeated measures design measures dietary intake urinary hydration status body mass recorded week preceding competition body mass decreased significantly baseline rwg period body mass increased significantly exceeding rwl mean energy carbohydrate intake kcal day day respectively official weigh athletes dehydrated mosmol remaining severely dehydrated mosmol athletes reported using harmful dehydration based rwl strategies including sauna training plastic suits results demonstrated rwg greater rwl novel finding may attributable duration weigh till competition observed magnitude rwl strategies used comparable previously resulted fatalities rule changes make rwl impractical implemented immediate effect ensure health safety wellbeing competitors
water harvesting systems traditional technologies met needs local populations many centuries indicating systems clearly sustainable simply defined method inducing collecting storing conserving local surface run future productive use one oldest commonly used sustainable water management systems india various types systems harvest rainwater india ranging simple complex industrial systems examples traditional rainwater systems india include bamboo pipes apatani systems eastern himalayas ghul western himalayas zabo cheo ozihi north eastern india dongs garh dara brahmaputra valley kund khadin talabs beri johad baoli etc thar desert gujrat havelis jabalpur bandh bandhulia satna virda gujarat ahar pynes bihar eri kulam eastern coastal plains jackwells islands showed immense structural simplicity high efficiency almost forts india built different terrains climatic conditions elaborate arrangements drinking water old temples south india built centuries ago large tanks premises tanks either fed harvested rain water tapping underground springs traditional water wisdom levels society ensured adequate availability water turn formed basis round development prosperity learn comprehend ancient knowledge apply modern society get rid present water stressed condition
large scale dynamic systems becoming highly pervasive occurrence applications ranging system biology environment monitoring sensor networks power systems characterised high dimensionality complexity uncertainty node dynamic interactions require computational demanding methods analysis control design well network size node system interaction complexity increase therefore challenging problem find scalable computational method distributed control design large scale networks paper investigate robust distributed stabilisation problem large scale nonlinear multi agent systems briefly mass composed non identical heterogeneous linear dynamical systems coupled uncertain nonlinear time varying interconnections employing lyapunov stability theory linear matrix inequality lmi technique new conditions given distributed control design large scale mass easily solved toolbox matlab stabilisability node dynamic sufficient assumption design global stabilising distributed control proposed approach improves existing lmi based results mas overcoming computational limits extending applicative scenario large scale nonlinear heterogeneous mass additionally proposed lmi conditions reduced terms computational requirement case weakly heterogeneous mass common scenario real application network nodes links affected parameter uncertainties one main advantages proposed approach allow move centralised towards distributed computing architecture expensive computation workload spent solve lmis may shared among processors located networked nodes thus increasing scalability approach network size finally numerical example shows applicability proposed method advantage terms computational complexity compared existing approaches
introduction children communication checklist ccc bishop useful scale evaluation pragmatic verbal abilities school children aim study ascertain validity reliability ccc spanish subjects methods answers ccc items parents children normal intelligence analyzed five groups control children children attention deficit hyperactivity disorder procedural non verbal disorder children social communication disorder autism spectrum disorder investigations included factorial analysis order cluster checklist items reliability analyses proposed scales discriminant analysis check whether scale correctly classifies children pragmatic verbal abilities results seven factors obtained kaiser meyer olkin moderate similarity original scale social relationships interests five grouped pragmatic verbal ability conversational abilities coherence comprehension empathy nonverbal communication appropriateness factors significantly correlated control group five compose pragmatic verbal ability correlate clinical groups pearson scales good reliability cronbach alpha questionnaire correctly classifies grouped cases without pragmatic disorder subjects appropriate clinical group besides questionnaire allows differentiate pathologies according presence intensity symptoms conclusions spanish version ccc highly valid reliable proposed statistics used normative reference values
general synthesis method given realisation nth order lowpass voltage transfer function using active circuit containing minimum number capacitors current conveyors current conveyors noninverting type act voltage followers makes proposed circuit simple attractive
paper propose multi cue object representation image classification using standard bag words model ever since success bag words model image classification several modifications proposed literature variants target improve key aspects efficient compact dictionary learning advanced image encoding techniques pooling methods efficient kernels final classification step particular soft encoding methods sparse coding locality constrained linear coding fisher vector encoding received great attention literature improve upon hard assignment obtained vector quantization nevertheless methods come higher computational cost little attention paid extracted local features contrast propose novel multi cue object representation image classification using simple vector quantization show highly competitive classification performance compared state art methods popular datasets like caltech micc flickr apart object representation also propose novel keypoint detection scheme helps achieve classification rate comparable popular dense keypoint sampling strategy much lower computational cost elsevier ltd rights reserved
like many developing countries taiwan experienced social process constructing controlling population relied demography fertility studies essential governing tools article investigates population politics biopolitical knowledge production postwar taiwan synthesizing three bodies literature begun comment one another histories postwar population control analyses technoscientific turn cold war history forensics production social scientific knowledge via science study approaches along complexities asian biopolitics three main social elements affecting production biopolitical knowledge time discussed historical backstage cold war civil war met acting group taiwanese agencies individuals took part process three types fertility studies data ultimately expanded focus process population control population general reproductive behavior women complexities asia biopolitics also discussed
psychocutaneous disease defined review primary psychiatric disease skin manifestations commonly encountered dermatology dermatologists play important role management psychocutaneous disease patients visit dermatology treatment skin problems often refuse psychiatric intervention review describes common psychocutaneous syndromes including delusional factitious obsessive compulsive related eating disorders well psychogenic pruritus cutaneous sensory pain syndromes posttraumatic stress disorder sleep wake disorders updated classification disorders diagnostic statistical manual mental disorders edition included strategies management reviewed
background glycaemic control suboptimal large proportion people type diabetes consequently increased avoidable risk potentially severe complications sought explore attitudes practices among healthcare professionals may contribute suboptimal glycaemic control review recent relevant publications scientific literature methods electronic search pubmed database performed identify relevant publications january july electronic search complemented manual search abstracts key diabetes conferences available online results recently published data indicate glycaemic control suboptimal substantial proportion typically people diabetes case across geographic regions low higher income countries therapeutic inertia appears important contributor poor glycaemic control half people type diabetes particular prescribers often willing tolerate extended periods mild hyperglycaemia well low expectations patients often delays years longer initiating intensifying glucose lowering therapy needed conclusion many people type diabetes failed current management approximately half achieving maintaining appropriate target blood glucose levels leaving patients increased avoidable risk serious complications review criteria methodology review article detailed methods section
objective examine day readmission rates associations risk factors survival length hospitalization costs elderly patients laryngeal oropharyngeal squamous cell cancer scc study design retrospective cross sectional analysis surveillance epidemiology end results medicare data methods evaluated patients diagnosed laryngeal oropharyngeal scc underwent primary surgery using cross tabulations multivariate regression modeling survival analysis results thirty day readmission occurred hospitalizations readmission likely patients postoperative complications initial hospitalization associated increased day mortality incidence rate multivariate analysis day readmission significantly associated advanced stage odds ratio comorbidity divorced separated marital status preoperative tracheostomy major surgical procedures greater length initial hospitalization pneumonia postoperative dysphagia cardiovascular events thirty day readmission significantly associated day mortality higher year mortality mean incremental costs surgical care significantly greater patients unplanned readmission controlling variables conclusion unplanned readmissions associated increased short long term mortality costs elderly patients advanced disease advanced comorbidity lack spousal support pretreatment organ dysfunction extensive surgery postoperative pneumonia postoperative dysphagia prolonged hospitalization increased risk day readmission findings suggest need targeted interventions hospitalization reduce morbidity mortality excess costs high risk population level evidencec laryngoscope
gain better understanding dimensions characteristics phenomenon child maltreatment policy responses philippines article provides systematic review peer reviewed literature review provides summary analysis core child maltreatment issues philippines examines child protection policy responses takes systematic approach identifying peer reviewed articles diverse range scholarship met criteria subjected quality appraisal tool findings provide important details child maltreatment child protection arrangements philippines recommends research policy programmatic approaches child maltreatment greater focus social cultural structural influences child maltreatment investigation child maltreatment particularly child sexual abuse contexts outside home institutions
new type seismic isolator adjustable stiffness proposed based smart material magnetorheological elastomers mres paper specifies working principle isolator analyses magnetic induction distribution three different types mre isolators unicoil magnetic energy input twin coil magnetic energy input laminated steel plate coiling magnetic energy input respectively research shows third type input produces relatively greater magnetic induction elastomer area compared first two magnetic field evenly distributed mre area therefore best structure eventually mechanical model mre isolator made two steel slices one elastomer slice established together mechanical model made multi steel slices multi elastomer laminated structure furthermore numerical analysis completed results show mre isolators content adjustable behaviour
violent video game vvg use repeatedly found associated hostile expectations others desensitization violence decreased empathy prosocial behavior aggressive thoughts behaviors although research findings widely publicized vvgs remain extensively played games represent multi billion dollar industry although vvgs typically rated mature indicating suitable youths often purchased youths may part currently system available consumers thoroughly describes content video games much public unaware types violence characterize game play purpose paper describe violent content top vvgs based sales purposes issue acts senseless unprovoked violence described detail
open source musculoskeletal model predictions lumbar muscle forces presented paper model based previously published anatomically detailed lumbar spine model upper extremity lower extremity head neck models incorporated implemented opensim open source musculoskeletal modeling platform features model include ability predict joint reactions lumbar muscle forces lumbar muscle activation patterns validate ability model predict lumbar loading loads acting vertebral bodies several conditions determined compared loads measured vivo using instrumented vertebral body replacements pressure transducers intervertebral discs model predicted loads strongly correlated measured loads thus model successfully predicts variations loading different conditions model introduced ultimately aid ergonomics machine design since current machines still mainly designed without knowing reasonable lumbar loads
identify multiple degree freedom vibrating structures local nonlinearities two stage time domain approach based subspace method proposed study locally nonlinear system identified divided underlying linear part described frf local nonlinear part described nonlinear coefficients identification process proposed approach existing single stage method identifies underlying linear system local nonlinearities proposed approach reduces dimensions matrices used calculate system state space model also gives appropriate estimation order underlying linear system utilization classical spectrum estimation techniques numerical experimental examples given verify performance method results show method accurate reliable single stage method especially noisy environment
marie darrieussecq truismes reinvented metamorphosis narrative prompting rich interpretations past two decades however critic yet explored significance menopause uniquely human transition understanding transformation fact narrator protagonist body experiences menopausal symptoms hot flashes weight fluctuation alterations hair skin visualizes womb experiences menopause metamorphose une vieille truie article surveys historical social perceptions menopause france darrieussecq exposes fiction explores work writes confronts passage womanhood overturning historically established preconceptions female aging rather representing menopausal body barren space devoid interest truismes finds fertile ground allow women discover inner worth creativity worthy sharing even publishing
study prevalence erectile dysfunction serum sexual hormone levels evaluated men obstructive sleep apnea osa patients efficacy continuous positive airway pressure cpap determined men mean age years enrolled study stratified within four groups based apnea hypopnea index score simple snoring mild osa moderate osa severe osa international index erectile dysfunction iief score obtained patient blood samples analysis sexual hormones prolactin luteotropin follicle stimulating hormone estradiol progestin testosterone drawn morning polysomnography iief test serum sexual hormone measurements repeated months cpap treatment men severe osa prevalence osa patients overall severe osa compared simple snoring group patients severe osa significantly lower testosterone levels lower iief scores differences sexual hormones groups significant months cpap treatment significant changes sexual hormone levels iief score improved significantly severe osa patients low testosterone concentration high prevalence iief scores increased significantly cpap treatment effect serum testosterone levels
four benzofuran conjugated iridium iii rhodium iii based metal complexes synthesized screen inhibitor stat activity prostate cancer cells complexes show high stability solubility biological system study iridium iii complex engages stat kappa inhibit translocation transcriptional activities moreover complex shows potential antiproliferative activity cells suppresses tumor growth prostate cancer xenograft mouse without observable adverse effects complex may provide basis developing new therapeutic strategy vivo vitro treatment advanced prostate cancer elsevier rights reserved
ability perceive infer meaning facial expressions considered critical component emotional intelligence essential successful social functioning longitudinal findings suggest ability recognize emotion cues related positive social interactions moreover pronounced recognition abilities least emotions facilitate prosocial behavior everyday situations integrating paradigms behavioral economics psychometrics used interdisciplinary approach study relationship prosociality trait cooperativeness ability recognize emotions others measured emotion recognition accuracy era using multivariate test battery captured prosocial behavior standard socio economic games along spontaneous emotion expressions structural equation modeling revealed significant relationship overall era prosocial behavior however modeling emotion specific factors suggested prosocial individuals better recognizing fear tend express spontaneous emotions prisoner dilemma cooperative individuals seem sensitive distress others expressive possibly fostering reciprocal interactions like minded others elsevier inc rights reserved
graphene based ink printing passive electrical components conductive traces resistors capacitors inductors circuitry mechanically flexible polymer substrates described paper ink synthesized using carboxymethyl cellulose cmc hydrophilic cellulose derivative suspend naturally hydrophobic graphene sheets aqueous solvent composed water butoxyethanol deposited functionalized substrate conductivity printed electrical components optimized decomposing cellulose stabilizer using thermal reduction several printed passive electrical circuits fabricated tested including interdigitated capacitive chemical sensor low pass electrical filter measured characteristics printed circuits compared theoretical values performance validation mechanical bending tests also performed demonstrate thermally modified cmc films absorb large levels strain without fracturing degrading electrical properties
background aims recent research problematic facebook use highlighted need develop specific theory driven measure assess potential behavioral addiction aim present study examine factorial validity problematic facebook use scale pfus adapted caplan generalized problematic internet scale model methods total italian adolescents young adults aged years participated study confirmatory factor analyses performed order assess factorial validity scale results results revealed factor structure pfus provided good fit data furthermore results multiple group analyses supported invariance model across age gender groups discussion conclusions study provides evidence supporting factorial validity pfus new scale provides theory driven tool assess problematic use facebook among male female adolescents young adults
introduction patients philadelphia negative chronic myeloproliferative neoplasms mpn polycytemia vera essential thrombocythaemia primary myelofibrosis pmf prone develop thrombotic events aimed investigate coagulation status plasma using thrombin generation assay tga functional global assay ceveron alpha materials methods samples collected consecutive negative mpn patients controls kedta ctad tubes blood cell counts tga coagulation screening tests thrombin generation analysed platelet poor plasma using technothrombin tga assay kit results found significantly increased peak thrombin generation velocity index patients comparison controls especially patients significantly higher values peak thrombin patients receiving anagrelide comparison treated hydroxyurea also noticed inverse correlation length cytoreductive therapy tga parameters peak thrombin auc conclusion results suggest mpn patients especially predisposed thrombotic events due higher peak thrombin values risk may decreases treatment longer patients treated hydroxyurea generate less thrombin could less prone develop thrombotic events comparison treated anagrelide
sleep known affect learning memory extent influences behavioural processing left right hemispheres brain yet unknown tested two hypotheses lateralised effects sleep recognition memory words whether sleep reactivated recent experiences words promoting access long term store left hemisphere whether sleep enhanced spreading activation differentially semantic networks hemispheres experiment participants viewed lists semantically related words slept stayed awake tested seen unseen related unrelated words presented left right hemisphere sleep found promote word recognition spread activation equally within semantic networks hemispheres experiment ensured results due time day effects influencing cognitive performance elsevier inc rights reserved
part paper proposed analyzed novel algorithmic framework minimization nonconvex objective function subject nonconvex constraints based inner convex approximations part devoted nontrivial application framework following relevant large scale problems ranging communications machine learning generalizations rate profile maximization mimo interference broadcast networks max min fair multicast multigroup beamforming problem multicell environment general nonconvex constrained criteria formulation sparse variable selection statistical learning two criteria nonconvex loss objective function measuring fitness model data latter nonconvex sparsity inducing constraint general form difference ofconvex functions allows accomodate unified fashion convex nonconvex surrogates function proposed algorithms outperform current state art schemes theoretically numerically instance first distributed schemes class problems also lead subproblems enjoying closed form solutions
background reward punishment sensitivities identified potential contributors binge eating compensatory behaviors though studies examined gender differences behaviors method college aged sample completed eating disorders diagnostic scale edds sensitivity punishment sensitivity reward questionnaire spsrq results rates binge eating similar males females among reporting compensatory behaviors women reported engaging compensatory behaviors frequently men sensitivity reward sensitivity punishment positively associated binge eating frequency genders contrast women high reward sensitivity reported engaging compensatory behaviors frequently conclusions rates binge eating compensatory weight control behaviors similar college aged males females though females engaged compensatory behaviors frequently males sensitivity punishment greater females whereas sensitivity reward greater males reward punishment sensitivity positively associated binge eating males females reward sensitivity positively associated compensatory behaviors females
chaotic systems nonlinear deterministic systems display complex unpredictable behavior chaos applied many academic engineering fields communication economic system chemical processes optimization fundamental part control engineering identication estimation parameters system controlled paper parameter identification problem random initial noises general class time delay chaotic systems unknown parameters time delays considered parameter estimation problem formulated multi dimensional optimization problem paper propose efficient optimization method called adaptive particle swarm optimization apso parameters estimation synchronization time delay chaotic systems effectiveness method tested time delay logistic chaotic system results compared population based methods simulation results show proposed algorithm robust efficient multi parameter estimation presence noise
aftershocks following large mainshock characterized clustering space time temporal decay number aftershocks follows empirical omori utsu law aftershocks regarded delayed responses stress changes induced mainshock therefore conventional wisdom dictates mechanical maxwell kelvin element must taken account modeling aftershock generation propose novel mechanism aftershock generation evaluating changes stiffness ratio stiffness two blocks dynamical one dimensional spring block model simulations reveal existence spatiotemporal event clustering aftershocks associated preceding large event mainshocks addition empirical omori utsu law similar hold many sequences numerical aftershocks produced model therefore suggest changes stiffness strength materials play important role aftershock generation elsevier rights reserved
background nucleoside reverse transcriptase inhibitors nrtis cornerstone antiretroviral therapy human immunodeficiency virus acquired immune deficiency syndrome hiv aids however use sometimes limited development painful sensory neuropathy respond well drugs smoked cannabis reported clinical trials efficacy relieving painful hiv associated sensory neuropathy objectives aim study evaluate whether expression endocannabinoid system molecules altered nrti induced painful neuropathy also whether endocannabinoids attenuate nrti induced painful neuropathy methods balb mice treated dideoxycytidine ddc zalcitabine nrti induce thermal hyperalgesia expression endocannabinoid system molecules evaluated real time polymerase chain reaction brain spinal cord paw skin days post ddc administration time point mice developed thermal hyperalgesia effects endocannabinoids arachidonoyl ethanolamine aea arachidonoyl glycerol cannabinoid type receptor antagonist receptor antagonist protein coupled receptor gpr antagonists cid ddc induced thermal hyperalgesia evaluated using hot plate test results ddc treatment resulted thermal hyperalgesia increased transcripts synthesizing enzyme plc beta decreased dagl beta paw skins napepld dagl alpha compared vehicle treatment transcripts inactivating enzymes faah mgll downregulated brain paw skin spinal cord ddc treated mice aea antihyperalgesic effects mice ddc induced thermal hyperalgesia effect ddc naive mice antihyperalgesic activity aea antagonized whereas activity antagonized cid conclusion data show ddc induces thermal hyperalgesia associated dysregulation mrna expression endocannabinoid system molecules endocannabinoids aea antihyperalgesic activity dependent cannabinoid receptor gpr activation thus agonists cannabinoid receptors gpr could useful therapeutic agents management nrti induced painful sensory neuropathy
purpose headache common presenting feature patients pituitary adenomas tumors sellar region however present still unclear whether headache actually caused tumor explore whether relation examined detail headache types relationship underlying pathology headache responded neurosurgery prospective study design methods one hundred twelve patients tumors sellar region scheduled neurosurgery single center analyzed presence quality headache surgery least months surgery patients received headache depression self rating inventories presented handheld computer paindetect clinical variables thought impact headache analyzed conjunction inventories results fifty nine patients reported headache months prior neurosurgery headache time filling questionnaires four patients pituitary apoplexy described thunderclap headache patients diverse headache types encountered frequently migraine untreated gonadotroph deficiency significantly associated absence headache none clinical morphological variables related headache presence headache disability due headache significantly reduced surgery conclusion apart pituitary apoplexy detected specific headache type patient group significant improvement headache neurosurgery headache alone constitutes neither valid diagnostic marker presence tumors sellar region sufficient indication tumor removal
using online comments posted news stories context study aimed examine interplay third person perception tpp people believe media message greater effect changing attitudes others compared online incivility also examined whether people agreement content comments would influence tpp results experiment showed incivility muted persuasive effect online comments civil comments produced tpp whereby people felt comments greater persuasive power others compared however counter predictions whether people agreed comments influence tpp findings also supported tpp social distance corollary subjects perceived comments largest third person perceptual gap self disagreed results discussed relation tpp face politeness theories elsevier ltd rights reserved
paper design novel high speed low cost autonomous line following robot combines human expert knowledge experiential data extracted neural network training proposed implemented proposed autonomous robot overcomes disadvantages earlier designs like oscillations motion exception handling high cost high energy consumption robot uses novel square topology infrared sensor matrix enables anticipate turn sensing track ahead three different strategies control high speed line following robots presented neural network based control strategy learning vector quantization based strategy reinforcement learning based strategy final design based hybrid neural network based control strategy smoothly followed benchmark track neurons used low cost bit microcontroller implement control system elsevier ltd rights reserved
health care changing rapidly must change times develop efficient practical cost effective importantly high quality methods care patients teach medical students optimal patient care requires face face interaction collect information patient history perform physical examination however management many patients especially chronic diseases always require physical examination telemedicine offers opportunity take advantage technology leveraging progressive push toward efficiency value also requires belief excellent patient care always provided person telemedicine include variety aspects patient care adapted performed remotely telemonitoring tele education teleconsultation telecare evaluated gastroenterology practice demonstrated feasibility patient preference produced mixed results regarding patient outcomes combining telemedicine tools new care models redesign chronic disease management include fewer person visits patients well yet increase access patients need seen change could lead higher value care improving experience care decreasing costs improving health population barriers include reimbursement licensing fear litigation however hope meet needs patients within changing health care system telemedicine incorporated strategy
paper proposes novel hybrid optimisation algorithm combines recently proposed evolutionary algorithm backtracking search algorithm bsa another widely accepted evolutionary algorithm namely differential evolution proposed algorithm called bsa employed optimal designs two commonly used analogue circuits namely complementary metal oxide semiconductor cmos differential amplifier circuit current mirror load cmos two stage operational amplifier amp circuit bsa simple structure effective fast capable solving multimodal problems stochastic population based heuristic approach capability solve global optimisation problems paper transistors sizes optimised using proposed bsa minimise areas occupied circuits improve performances circuits simulation results justify superiority bsa global convergence properties fine tuning ability prove promising candidate optimal design analogue cmos amplifier circuits simulation results obtained amplifier circuits prove effectiveness proposed bsa based approach harmony search artificial bee colony abc pso terms convergence speed design specifications design parameters optimal design analogue cmos amplifier circuits shown bsade based design technique amplifier circuit yields least mos transistor area designed circuit shown best performance parameters gain power dissipation etc compared recently reported literature
lack appropriate animal models affective disorders major factor hindering better understanding underlying pathologies development efficacious treatments circadian rhythms play important role affective disorders recently suggested diurnal rodents advantageous model animals found diurnal rodents short photoperiod induces depression anxiety like behaviors similarities human seasonal affective disorder pilot study also found behaviors ameliorated morning bright light administration present study evaluated effects morning evening bright light administration short photoperiod induced depression anxiety like behaviors diurnal fat sand rats animals maintained short neutral photoperiod treated morning evening bright light red dim light control morning bright light ameliorated behavioral deficits elevated plus maze social interaction tests whereas evening bright light effective social interaction test first detailed presentation effects bright light treatment animal model clear demonstration advantages utilizing diurnal rodents study interactions circadian rhythms affect
background partners cancer patients report psychological distress reduced quality life however partners mental health status quality life child rearing years influence social support hardiness well yet studied objective aim study describe psychological distress quality life social support hardiness partners facing spousal cancer child rearing years investigate whether social support hardiness moderated relationship psychological distress quality life methods cross sectional data collected norway december july part cancer pepsone study results five questionnaires administered females males participants reported psychological distress lower quality life scores healthy norwegian populations psychological distress seemed associated control futures received social support moderated effect psychological distress quality life conclusions facing spousal cancer child rearing years seemed substantial impact partners mental health adverse impact quality life accordingly partners self care abilities may reduced received social support may reduce multiple burdens consequently allow enhancement self care implications practice interventions aim improve social support provided child rearing partners may improve quality life providing adequate information partner cancer illness treatment may enhance feelings control may beneficial mental health status
study examines women media selections gender math stereotype threat subsequent media effects math performance lens selective exposure self affect management sesam model mood management theory social comparison theory female college students randomly assigned stereotype threat condition control condition selectively browsedmagazine pages showing female role models stereotypical domains beauty family counterstereotypical domains career science taking math test results show women spent time career magazines threat selective exposure effect math performance moderated assimilation role models
due contention shared disk bandwidth user intensity significantly impact performance online low priority background tasks thus reducing reliability availability raid structured storage systems paper propose novel practical scheme called workout workload outsourcing significantly boost performance low priority background tasks workout effectively outsources write requests popular read requests originally targeted degraded raid set performing low priority background tasks surrogate raid set lightweight prototype implementation workout extensive trace driven benchmark driven experiments two case studies demonstrate compared existing approaches workout effectively improves performance low priority background tasks raid reconstruction raid resynchronization importantly workout portable easily incorporated existing optimizing algorithms raid structured storage systems
feedforward control enables high performance motion system recently algorithms proposed eliminate bias errors tuning parameters feedforward controller aim paper develop new algorithm combines unbiased parameter estimates optimal accuracy terms variance simulation study presented illustrate poor accuracy properties pre existing algorithms compared proposed approach experimental results obtained industrial nanopositioning system confirm practical relevance proposed method
applications artificial intelligence considerably expanded recent years new class industrial systems beginning evolve incorporates using high volume data advanced analytics better optimize product quality reducing energy consumption artificial neural networks ann combined advanced modeling control begins form platform enhanced factories future paper provides demonstration initial work developed future systems generic way considering polymer processing plastic injection molding mold cavity temperature mct profile directly relates part quality part reject rates therefore desirable optimize mold cooling process using real time control mct directly affect part quality however mct affected number interacting nonlinear dynamic parameters often neglected due challenge quantifying parameters advanced model based control algorithms often used providing improved control complex systems however depend good model formulations analytically insufficient online intelligent system identification approach mold cooling process developed tested ann designed adjust online sub space parameters govern mold cooling model results demonstrate online ann approach used accurately predict dynamic behavior mold cavity surface temperature key many industrial systems states directly observable uncertainties unknown methodology readily adapted different operating conditions case polymer processing good potential integration advanced model based control schemes cloud computing approaches next generation machines elsevier ltd rights reserved
background hashimoto thyroiditis considered common autoimmune disease currently accepted genetic susceptibility environmental factors immune disorders contribute development regard nutritional factors evidence implicates high iodine intake deficiencies selenium iron potential relevance vitamin status elucidate role nutritional factors risk pathogenesis treatment pubmed cochrane library searched publications iodine iron selenium vitamin risk treatment summary chronic exposure excess iodine intake induces autoimmune thyroiditis partly highly iodinated thyroglobulin immunogenic recent introduction universal salt iodization similar though transient effect selenoproteins essential thyroid action particular glutathione peroxidases protect thyroid removing excessive hydrogen peroxide produced iodination genetic data implicate anti inflammatory selenoprotein risk evidence observational studies randomized controlled trials selenium selenoproteins reduce thyroid peroxidase tpo antibody titers hypothyroidism postpartum thyroiditis iron deficiency impairs thyroid metabolism tpo enzyme responsible production thyroid hormones heme iron containing enzyme becomes active apical surface thyrocytes binding heme patients frequently iron deficient since autoimmune gastritis impairs iron absorption common morbidity treatment anemic women impaired thyroid function iron improves thyroid hormone concentrations thyroxine iron together effective improving iron status lower vitamin status found patients controls inverse relationships serum vitamin tpo antibodies reported however data lack trial evidence suggest low vitamin status likely result autoimmune disease processes include vitamin receptor dysfunction conclusions clinicians check patients iron particularly menstruating women vitamin status correct deficiency adequate selenium intake vital areas iodine deficiency excess regions low selenium intake supplement day selenium may appropriate
study investigated whether minocycline second generation tetracycline proposed add antipsychotics treatment resistant schizophrenia trs may affect expression homer arc postsynaptic density psd transcripts implicated synaptic regulation minocycline administered alone haloperidol rats exposed ketamine mimicking acute glutamatergic psychosis naturalistic conditions respectively arc expression significantly reduced minocycline compared controls minocycline combination haloperidol also significantly reduced arc expression compared controls haloperidol alone moreover haloperidol minocycline combination significantly affected arc expression cortical regions haloperidol alone ineffective cortical gene expression results suggest minocycline may strongly affect expression arc mediated haloperidol terms quantitative levels topography haloperidol related expression noteworthy significant pre treatment effect found suggesting pre exposure ketamine grossly affect gene expression minocycline found significantly affect haloperidol related homera expression significant changes homerb expression observed results consistent previous observations minocycline may modulate postsynaptic glutamatergic transmission affecting distinct downstream pathways initiated methyl aspartate nmda receptor modulation arc mediated homera mediated pathways
degradation quality life threat brain disorders become serious concern past decades dementia one abnormality includes group symptoms deteriorate cognitive functions brain use neuroimaging techniques revealed abnormal anatomy corpus callosum diagnosing various brain disorders paper focuses classification magnetic resonance images dementia using features segmented mid sagittal brain image using means clustering algorithm used feature extraction significant features demented normal groups identified using statistical analysis depending upon statistical significance hybrid feature vectors designed male female dataset support vector machine svm back propagation neural network bpnn classifiers trained tested using designed feature vectors considering sexual dimorphism structure feature classification performed separately male female data paper reports highest classification accuracy male data female data
cointegration analysis particularly sensitive outlying observations traditional robust approaches rely parameter estimates based weighting schemes penalize aberrant units particular idea underlying pseudo maximum likelihood robust estimators atypical observations however reveal useful information investigated phenomenon aiming detect observations extend forward search procedure cointegrated vector autoregressive model analysis carried building subsets increasing dimension monitoring suitable statistics subset size simulation experiments real data analysis highlight forward search effective pseudo maximum likelihood detecting atypical units data structures
geotextile filters currently consideration potential treatment method removing suspended solids urban stormwater runoff one important aspect assessing viability new filter duration function becoming clogged predicting hydraulic conductivity filter throughout filter lifespan one way duration use determined study semi theoretical model developed predicts hydraulic conductivity filter system function mass solids captured geotextile values several parameters theoretical model empirically derived using laboratory data using values parameters analyzed functions specific characteristics geotextile filters simulated stormwater containing targeted suspended solids
recent years ambient intelligence ami attracted increased attention within advanced technology industry effort modernize develop intelligent reliable information system technologies detect specific object images expected expand wide range applications car detection functions intelligent transport system systems computer vision pattern recognition emerging fast continue grow together local feature detection methods paper propose object detection tracking system based scale invariant feature transform sift speed robust features surf feature extraction methods evaluation results observe accuracy matched keypoints surf algorithm higher sift
partial label learning aims learn training examples associated set candidate labels among one label valid training example basic strategy learn partial label examples disambiguation trying recover ground truth labeling information candidate label set one popular machine learning paradigms maximum margin techniques employed solve partial label learning problem existing attempts perform disambiguation optimizing margin maximum modeling output candidate labels non candidate ones nonetheless formulation ignores considering margin ground truth label candidate labels paper new maximum margin formulation partial label learning proposed directly optimizes margin ground truth label labels specifically predictive model learned via alternating optimization procedure coordinates task ground truth label identification margin maximization iteratively extensive experiments artificial well real world datasets show proposed approach highly competitive well established partial label learning approaches
sinus augmentation procedure demonstrated highly predictable treatment posterior maxilla atrophy surgical interventions maxillary region require deep knowledge anatomy possible anatomical variations article pre operative post operative assessments sinus cavity well novel approaches deepen knowledge behavior bone substitute materials described awareness patient morphologic conditions enables exact planning invasive surgery aids avoid complications pre operative radiologic evaluation region sinus lift advisable planning sinus augmentation selection alignment optimum placement implants orthopantomography possible measure vertical dimension graft volume changes cone beam computed tomography cbct become gold standard plan comprehensive implant treatment achieve post operative assessment computer aided design computer aided manufacturing cad cam technique proposed produce custom made block grafts sinus lift procedure customized cutting guide accurately place lateral wall ease membrane elevation procedure allows reduce intervention time precisely adapt scaffold reduce risk complications improve operation quality recently novel approach used deepen knowledge behavior bsbs means synchrotron micro tomography sct analyzing method suitable examine dynamic spatial arrangement regenerative phenomena complex anatomical structures bone tissues several morphologies alveolar process unmineralized extracellular matrix regenerated vessels etc compete achieve final goal bone regeneration
paper describes implementation spi programmable clock delay chip based delay locked loop dll order shift phase lhc clock steps less jitter dnl delay lines integrated icecal lhcb calorimeter front end analog signal processing asic near future stringent noise requirements asic imply minimizing noise contribution digital components accomplished implementing dll differential mode achieve required radiation tolerance several techniques applied double guard rings pmos nmos transistors well glitch suppressors tmr registers chip implemented cmos technology
random forest widely used classifier show good performance hyperspectral data classification however performance could improved increasing diversity characterizes ensemble architecture paper propose novel ensemble approach namely rotation random forest via kernel principal component analysis rorf kpca particular original feature space first randomly split several subsets kpca performed subset extract high order statistics obtained feature sets merged used input classifier finally results achieved step fused majority vote experimental analysis conducted using real hyperspectral remote sensing images evaluate performance proposed method comparison rotation forest support vector machines rorf pca obtained results demonstrate effectiveness proposed method
paper investigate coupled cubic quintic nonlinear schrodinger equations variable coefficients describe effects quintic nonlinearity ultra short optical pulse propagation non kerr medium twin core nonlinear optical fiber waveguide certain constraints variable coefficients equations mixed type bright dark vector one two soliton solutions derived via hirota method symbolic computation vector soliton solutions related delayed nonlinear response effect nonlinearity graphic analysis find delayed nonlinear response effect nonlinearity affect vector soliton amplitude vector soliton velocity merely depends delayed nonlinear response effect choice variable coefficients representing delayed nonlinear response effect nonlinearity interactions amplitude velocity unchanging amplitude changing velocity changing amplitude velocity changing vector two solitons obtained see interaction vector two solitons elastic also find interaction period bound vector solitons decreases increase delayed nonlinear response effect increases decrease delayed nonlinear response effect independent nonlinearity
mechanical properties soft materials critically important wide range applications ranging packaging biomedical purposes constructed simple mechanical testing apparatus using shelf materials open source software total cost less device consists wooden frame supporting central loading apparatus attached via drawer slides perform mechanical test sample secured within two custom made printed clamps affixed brackets base frame load cell extension force applied user pulling rope moving central loading apparatus thereby stretching sample recording force measured load cell displacement measured ultrasonic sensor load cell ultrasonic sensor linked arduino microcontroller connected laptop usb port data acquisition analysis instrument easy assemble enabled students better grasp meaning tensile testing promoting experimentation electronics computer programming mechanical design low cost ease use arduino based uniaxial tensile tester ideal device introduce concepts mechanical properties among concepts students numerous fields
dual energy ray imaging vast range application security luggage inspection essential process airplane court house security well securing mass events image content package may help figure dangerous object inside avoid possibly threatening situation raw ray images always easy analyze interpret image processing methods like object detection frequency resolution increase pseudocoloring used since color powerful tool improve usefulness information display propose pseudocoloring improvement modifying material based approach edge detection fill sharpen color layers image making easier read analyze demonstrate effectiveness methods using real data acquired professional dual energy ray scanner
dielectric electro active polymer deap suitable actuator material finds wide applications field robotics medical areas material highly controllable flexible capable developing large strain influence geometrical behavior becomes critical material used miniaturized actuation devices robotic applications present work focuses effect surface topography performance flat single sheet stacked rolled deap actuators non active areas form elliptical spots affect performance actuator identified using scanning electron microscope sem energy dissipated ray edx experiments performance deap actuation critically evaluated compared presented analytical experimental results
investigation market entry strategies critical success international contractors establishing partnerships among effective vehicles operating international markets major objective paper analyze partnership behavior contractors overseas projects respect social network analysis sna used better understand collaborative project networks different markets projects differing sizes database developed based collaborative international construction projects turkish firms non turkish partners involved total projects carried countries used analysis findings study suggest contractors adopt different strategies depending market project characteristics majority companies tend remain markets keep working partners choose local partners engage multiple partners complex projects study expected help contractors reflect internationalization decisions devise appropriate strategies establish project networks
paper presents estimation power output produced electro active paper eapap energy harvesting transducer base vibration eapap thin cellulose piezoelectric film exhibits direct piezoelectric effect subjected stress eapap patch bonded aluminum cantilever structure energy harvesting tests performed energy harvesting transducer without grams proof mass near tip cantilever beam voltage current power frequency response functions frfs respect base acceleration identified presented voltage frfs show monotonic trend increasing load resistor omega omega current frfs also demonstrate monotonic dynamic behavior trend opposite voltage frfs contrast voltage current frfs output power frfs show monotonic trend exhibiting maximum value without proof mass output power increases proof mass attached preliminary study indicates eapap promising energy harvesting transducers vibration environment
although child maltreatment medical research benefited several multi center studies new specialty child abuse pediatrics sustainable network capable pursuing multiple prospective clinically oriented studies child abuse pediatrics network capnet new multi center research network dedicated child maltreatment medical research order establish relevant practical research agenda conducted modified delphi process determine topic areas highest priority network research questions solicited members ray helfer society study authors sorted topic areas topic areas rated priority using iterative rounds ratings person meetings topics rated highest priority missed diagnosis selected indicated prevention agenda used target future multi center child maltreatment medical research elsevier ltd rights reserved
output performance reluctance synchronous machine strongly depends well designed machine draft since many different requirements concerning output capability machine design done considering specifications demands also determined field application however machine design optimization genetic algorithm simple comparatively fast method achieve adequate results therefore presented within publication outcome optimization course depends algorithm provided design variables well calculation model concealed behind case analytical model based simplified magnetic circuit analysis used fitness value computation calculation method provides good results regarding major parameters like axis inductances well axis currents within genetic algorithm optimization flexible design reluctance synchronous machines terms specific requirements easily accessible result important conclusions regarding stator rotor geometry achieved
cognitive fatigue important confound impacting cognitive performance triggered features make cognitive effort perceived exhausting remain unclear theoretical framework time based resource sharing tbrs model barrouillet hypothesized outcome increased cognitive load due constrained time process ongoing cognitive demands tested cognitive load related hypothesis across experiments manipulating task complexity cognitive load induced processing time interval used tloaddback paradigm working memory dual task high low cognitive load levels individually adjusted experiment participants administered high cognitive load hcl short processing time interval low cognitive load lcl large processing time interval conditions complexity task kept constant back dual task experiment two tasks featuring different levels complexity administered individual maximal processing speed capacity task short processing time interval results disclosed higher hcl lcl condition experiment contrary experiment similar levels obtained different levels task complexity processing time interval individually adjusted induce hcl condition altogether results indicate processing time related cognitive load eventually leads subjective feeling decrease alertness framework propose development envisioned result sustained cognitive demands irrespective task complexity elsevier ltd rights reserved
chronic hepatitis virus hcv infection associated renal dysfunction daclatasvir asunaprevir combination therapy showed high virological response genotype chronic hcv infected patients renal dysfunction hemodialysis however safety efficacy therapy patients renal dysfunction hemodialysis well known total patients chronic hcv genotype infection treated weeks daclatasvir plus asunaprevir therapy among patients normal renal function estimated glomerular filtration rate egfr min renal dysfunction egfr min plasma concentrations daclatasvir asunaprevir days treatment normal renal function renal dysfunction groups early virological response start therapy similar two groups end treatment response achieved patients normal renal function renal dysfunction respectively sustained virological response achieved patients frequency adverse events also comparable two groups treatment discontinuation due adverse events required one patient group renal function change either treatment groups conclusion renal function unlikely significant impact blood kinetics daclatasvir asunaprevir combination therapy effective safe patients without hemodialysis wiley periodicals inc
chromium considered one major environmental hazards poses threat plant animal health selenium however recognized essential micronutrient plants understand role oxidative stress management regulation antioxidative defence mechanism heavy metal stress seedlings brassica juncea raised petri plates containing nutrient media supplemented combination observed causes increase reactive oxygen species ros seedlings leading oxidative stress histological studies using confocal visible microscopy confirmed biochemical results supplementation media containing reduced contents ros increased enzymatic non enzymatic antioxidants seedlings concentration however toxic results suggested appropriate concentrations exogenous application enabled juncea seedlings counteract effects thereby increasing resistance plants
suggested dogs ability comprehend human pointing gestures evolved product socio emotional changes associated domestication given large role played oxytocin system socio emotional processes possible hypothesize role oxytocin modulating dogs socio communicative skills indeed shown intranasal oxytocin enhances dogs ability use human pointing cues object choice task classic paradigm used assess ability follow pointing gesture tested hypothesis another sample dogs replicated findings also provided novel explanation findings suggesting oxytocin released human dog interactions increases positive expectations human behaviour via emotion reward processes thus facilitates interpretation pointing leading positive events given large deep homology across mammals neural mechanisms involved emotions oxytocin could involved acquisition socio communicative skills human typical well pathological development
rationalistic theories morality emphasize reasoning plays important role moral judgments prosocial behavior theory mind reasoning ability mental domain considered facilitator moral development present study examined whether theory mind consistently positively associated morality middle childhood late adulthood two hundred four participants including elementary school children adolescents younger adults older adults completed theory mind moral judgment prosocial behavior tasks theory mind measured strange stories tapped understanding lies white lies double bluffs irony persuasion moral judgments measured variants trolley dilemma prosocial behavior measured participants performance interactive situation helping request made results indicated specific rather similar developmental trajectories theory mind moral judgments prosocial behavior quadratic trend theory mind combination quadratic cubic trends deontological moral judgments linear decline helping behavior thus suggested theory mind may associated morality unchanging way development results indicated theory mind deontological moral judgments negatively correlated children adolescents older adults positively correlated younger adults theory mind helping behavior positively correlated children negatively correlated adolescents however relationships disappeared adulthood sum present study reveals theory mind may nice tool facilitation deontological moral judgments prosocial behavior may also nasty tool blocking deontological moral judgments prosocial behavior moreover theory mind may permanent tool moral judgment development temporary tool prosocial behavior development thus present study enriches rationalistic theories morality developmental perspective different relationships theory mind morality middle childhood late adulthood discussed
backgroundfinding associated factors childhood behavioural problems early preschool age important studies revealed several factors including socioeconomic factors may vary among different cultural background population however investigation general japanese population preschool age well demonstrated thus objective study examine associated factors childhood behavioural problems using strengths difficulties questionnaire sdq prospective birth cohort study methodstotal sdq distributed october december subpopulation prospective birth cohort study hokkaido study environment children health subpopulation consisted participants reached age born april december baseline questionnaire filled recruitment birth record used obtain participant information children total difficulties score defined likelihood behavioural problems total children valid answers included analysis response rate resultsnumber children likelihood behavioural problems boys showed problematic scores girls multivariate analysis found maternal pre pregnancy bmikg primipara maternal education lower high school family income pregnancy million yen year boy gender factors associated increased odds ratio likelihood child behavioural problems conclusionsthis study found prenatal socioeconomic factors associated likelihood child behavioural problems preschool age japan
study conducted order determine effect presence urinary incontinence sexual quality life women diagnosed chronic physical diseases sample cross sectional comparative study consisted female inpatients female inpatients without urinary incontinence complaints treated chronic physical diseases internal diseases clinic public hospital data collected using patient identification form international incontinence consultation questionnaire short form sexual quality life scale women average score women urinary incontinence took sexual quality life scale lower average score women without urinary incontinence negative meaningful relationship frequency amount effect urinary incontinence sexual quality life sexual quality life women years age respiratory system diseases duration illness years perceived general health bad parity gave normal birth menopausal period hysterectomies significantly lower result women chronic physical diseases urinary incontinence sexual quality life affected worse level compared urinary incontinence
prefrontal cortex pfc dependent functions executive function explicit learning memory negatively affected cocaine abusers experimental animal models cocaine treatment however molecular mechanisms less understood present study performed transcriptome profiling dynamic changes pfc repeated cocaine administration mice found differentially expressed genes degs days respectively withdrawal chronic cocaine treatment time series correlation analysis identified clusters statistically significant expression patterns expression levels degs clusters exhibited gradual fluctuant decrease cluster exhibited initial increase followed decrease return baseline level clusters exhibited fluctuant increase expression degs kyoto encyclopedia genes genomes kegg pathway analysis revealed genes related oxidative phosphorylation ribosomes neurodegenerative disorder enriched cluster genes related mitogen activated protein kinase mapk transforming growth factor tgf beta insulin signaling circadian pathways enriched cluster genes related plasticity related pathways enriched clusters genes related proteasome enriched cluster results suggest maladaptive neural plasticity associated psychostimulant dependence may ongoing degenerative process dynamic changes gene network different stages withdrawal furthermore could helpful develop new therapeutic approaches according different periods abstinence
background patellofemoral pain pfp considered one commonest forms knee pain study aimed identify physiotherapists united kingdom currently manage patellofemoral pain pfp particularly relation exercise prescription response pain methods anonymous survey designed reference previous surveys recent systematic reviews practising physiotherapists treat patients pfp invited take part via invitation email sent professional networks interactive chartered society physiotherapy icsp message board social media twitter descriptive statistics used analyse data results total surveys completed responders reported wide range management strategies including broad selection type dose exercise prescription five common management strategies chosen closed chain strengthening exercises education advice open chain strengthening exercises taping stretches physiotherapists special interest treating pfp statistically likely manage patients orthotics bracing compared physiotherapists without special interest approximately would prescribe exercise painful thirty one percent physiotherapists would advise patients continue leisure sporting activity experienced pain conclusion current practice management strategies pfp variable high quality research inform physiotherapy practice warranted troublesome musculoskeletal condition
tomorrows systems based close interactions mechanics electrics electronics control engineering sofhvare technology new materials well possessing inherent intelligence make superior mechatronics main features adaptability robustness proactivity intelligent systems multidisciplinary therefore need developed discipline spanning manner two targets arising one hand consistent superordinate process model hand appropriate support process model sufficient methods one step towards reaching targets formalization systems engineering traditional engineering systematic use different requirement levels given development process displayed contribution shown interpreted right way requirements provide one option interconnect different phases inside development process four levels requirements defined allocated development process process model applicability beneficial provide supporting methods discuss certain methods different development phases model starting goals development evolution goals towards functions systems described via enriched partial models provide early description system behavior interactions partial models requirement levels described increase consistency requirements functions system elements benefit emerging advantageous traceability requirements formalize requirements connections system analysis method presented quantifies connectivity element well degree connections inside entire system hence possibilities examining connections requirements goals system elements expanded
mechanical energy loss wall resistance important practical engineering problems investigated theoretical analysis numerical simulation paper results follows new mechanical energy equation total flow obtained general formula calculation mechanical energy loss proposed general relationship wall resistance mechanical energy loss steady channel flow obtained simplified form steady uniform channel flow consistent formula used hydraulics deduced theorem dimensional analysis steady channel flow backward facing step small expansion ratio numerically simulated mechanical energy loss wall resistance well relationship wall resistance mechanical energy loss calculated analyzed
overpopulation economic industrialization two common explanations deforestation political ecology however highlights good governance effective land management local level offset impact population growth development environmental degradation paper provide innovative argument derived political ecology explain deforestation rather pursing bottom approach governance take top approach argue state ease deforestation rates weaning rural populations consumption biomass energy needs expanding rural electrification access using panel analysis countries years find rural electrification cause deforestation rates decrease also robust explaining deforestation population growth development study provides two innovations political ecology highlights state help rather hinder local populations managing local environments sustainable way providing public goods based energy alternatives supplements political ecology qualitative focus environmental degradation generalized quantitative analysis state based initiatives deforestation results suggest current global initiatives addressing deforestation specifically reduction emissions deforestation forest degradation redd agenda united nations framework convention climate change assist local land managers also work state ensure universal access electricity elsevier ltd rights reserved
equality economic progress environmental sustainability essential developing country like india present time economy india growing rapidly vibrant mode efficient way turn demands huge uninterrupted energy supplies country energyneeds met mostly usage fossil fuels nearly electricity generated coal based power plants india nearly million people depend traditional biomass satisfy energy necessities approximately million rural people access modern lighting systems around million households access electricity major challenge india energy security order achieve stable sustainable energy long run significant progress renewable energy sectors needed favorably due india geographic location country blessed abundant renewable energy resources whith yet exploited completely central state governments country framed various policies providing subsidies encourage utilization solar photovoltaic systems paper comprehensive review potential current developmental status prospects solar energy india briefed various applications solar energy water heaters desalination units pasteurizers food drying units water purifier space heating systems air conditioning units cookers water pumps aerators solar wind hybrid systems grid connected photovoltaic systems explained study also mentions current renewable energy policies barriers blocking progress solar manufacturing units possible future recommendations might speed renewable energy developments india
complete structural health monitoring system implemented aizhai suspension bridge monitoring health status assessing safety long term services system consists nearly sensors various types including four subsystems automatic data collection subsystem artificial maintenance management subsystem early safety warning comprehensive assessment subsystem centralized database management subsystem deployments functions structural health monitoring system first introduced paper finite element model updating method combines substructure method response surface model updating method proposed reconstruct actual working state suspension bridge early safety warning comprehensive assessment subsystem remaining part temperature fields strain responses tension forces hangers longitudinal displacements stiffening girder meteorological temperature analyzed statistical analysis relationship temperature fields found temperature fields induced strains stiffening girder satisfies linear relationship cumulative probability distribution function cycle index daily stress amplitude follows weibull distribution monitored relative longitudinal displacements stiffening girder linearly related meteorological temperatures monitored tension forces hangers verify effects suspender free zones main cables normal hangers pylongirder detached suspension bridge american society civil engineers
capacitive charge division readout method reading array position sensitive solid state photomultipliers sspm designed evaluated using analog multiplexing method signals position timing sspm array reduced signals position timing allowing sspm array treated individual large area sspm module global positioning approach used instead individual positioning sspm array ensuring entire light signal utilized signal noise ratio snr flood histogram quality different bias voltages intervals fixed temperature degrees evaluated coupling array polished lso crystals center sspm array timing resolution measured fixed bias voltage fixed temperature degrees measurements evaluated compared using capacitors different values tolerances capacitor values ranged capacitance tolerance ranged results show better performance achieved using capacitors smaller values better capacitance tolerance using capacitors snr energy resolution timing resolution bias voltage respectively flood histogram quality also evaluated using array polished lso crystals array unpolished lso crystals determine smallest crystal size resolvable studies showed high spatial resolution sspm preserved allowing crystals identified results show capacitive charge division analog signal processing method significantly reduce number electronic channels retaining excellent performance detector
background since harm reduction program injecting drug users rolled countrywide china entails services condom promotion needle syringe program nsp methadone maintenance treatment mmt however remains unknown extent coverage services city level related reduced risk hiv infection among drug users methods wished quantify extent city level characteristics nsp mmt service coverage individual level determinants self reported exposure nsp mmt services knowledge motivation skills associated risk hiv infection among drug users conducted integrated serological behavioral survey among drug users five cities yunnan province china constructing multilevel logistic regression model drug users clustered within cities results drug users reported received nsp mmt services less likely infected hiv reported received nsp mmt despite city variation hiv infection risk icc none city level factors could explain difference individual level determinants perceived risk infection use condoms associated hiv infection conclusions although people used nsp mmt services less likely hiv infected study found relationship city level coverage hiv prevention programs variations hiv infection cities may due low number cities analysis future research include analysis data larger number cities collected widely china integrated behavioral serological surveys
semiconductor quantum dots extremely interesting photosensitizers development solar hydrogen generation however efficient quantum dots prepared toxic heavy metal limited high toxicity poor absorbance visible near infrared regions herein achieve effective composition regulation agin provides bandgap tunable quantum dots leading development high efficiency quantum dots photosensitizer low toxicity solar generation three component system combination molecular cobalt catalyst ascorbic acid sacrificial reagent composition agin quantum dots continuously tuned zns one end agins end resulting corresponding bandgap modulated gradually effect bandgap photocatalytic performance agin quantum dots investigated results show balance light absorption capacity driving force decided bandgap agin zns quantum dots leads highest efficiency visible light driven generation high apparent quantum yeild monochromatic irradiation obtained photocatalytic system efficiency best performance date solar generation system based free quantum dots believed bandgap tunable agin quantum dots would great potential durable lowly toxic photosensitizers replace commonly used based molecular dyes highly efficient solar generation elsevier rights reserved
study investigated effect different severities ckd femoral neck bone mineral density bmd patients treated denosumab study retrospective case review ckd patients treated denosumab baseline age sex body mass index bmi recorded patients comorbidities diabetes hypertension liver estimated glomerular filtration rate egfr serum collagen type cross linked telopeptide ctx also recorded subjects underwent dual energy ray absorptiometry assay femoral neck determine bmd changes femoral neck bmd baseline year denosumab administration recorded total patients ckd received denosumab therapy enrolled mean age years patients women baseline egfr correlated negatively changes bmd femoral neck rho lower egfr improvement bmd femoral neck denosumab therapy changes femoral neck bmd assessed outcome measures using linear regression young patients low egfr benefitted denosumab therapy denosumab therapy effective cases low egfr young age aggressive medical attention needed patients
respondents always explicitly state numeric value linguistic term suitable express opinions however answers mainly stored classical relational databases forcing answers crisp values way valuable information related vagueness opinions lost order avoid drawback data stored database capable manage fuzzy data adjusting classical relational databases storing fuzzy data promising option examined paper hence data analysis stored fuzziness fully exploited generally analyses performed get summarized information data focused analyzing particular tuples concerning former linguistic summaries extended cope fuzzy data concerning later focused revealing similar entities specified one risque optimistic anyway many analyses performed stored fuzzy data
article acquaints means dramatherapeutic intervention two addictions departments centre secondary prevention addiction treatment military hospital olomouc toxicorehabilitation department psychiatric hospital kromeriz first department runs detoxification short term one month intervention programme mandala medium term long half year dramatherapeutic programme implemented second part text presents results enquiry focused tracing differences connections clients perception benefits overall concept dramatherapeutic intervention said departments implementation questionnaire method reveal differences evaluations clients departments
previous findings diagnostic validity reliability generalized anxiety disorder gad associated symptom criteria suggest need evaluation current study examined convergent validity specificity gad associated symptoms representative singapore community sample singapore mental health study cross sectional epidemiological survey conducted among singapore residents aged older composite international diagnostic interview version used diagnose mental disorders associated symptoms gad criteria autonomic hyperactivity symptoms showed convergent validity gad diagnosis however associated symptoms gad also linked major depressive disorder mdd bipolar disorder obsessive compulsive disorder suggesting lack adequate specificity inability diagnostic criteria differentiate gad symptoms conditions highlights need better define associated symptoms criteria relationship overlapping symptoms gad mdd also discussed
introductory computer programming courses dry bored students often working short straightforward examples designed programming drills results professors ever see students might appreciate broader context college engineering programs students spend much time developing science technology engineering mathematics skills graduate start work engineering industry ill equipped communicate ideas engineers managers clients need develop engineering students communication skills come many times discussion industry representatives engineering education conferences high school students meanwhile usually focused getting high school may idea expected enter college problem professors queensborough community college face new group students work progress paper describe used high impact practice service learning help students reduce deficits describe strategy use students introductory programming course solve word problems require thought order solved students present group projects high school students final class session semester two groups students discuss presentations college experience general provides engaging memorable experience paper describe successes issues since started use method course
rheumatoid arthritis immune mediated disease primarily affects diarthrodial joints susceptibility severity disease influenced nongenetic factors environmental stress suggesting important role epigenetic changes review summarize epigenetic changes dna methylation histone modification mirna expression fibroblast like synoviocytes joint lining mesenchymal cells play important role joint inflammation damage also review effects epigenetic changes rheumatoid arthritis pathogenesis discuss therapeutic potential
investigate extent individuals global motivation self determined non self determined types influences adjustment anxiety positive reappraisal engagement intrinsic motivation task performance reaction changes level work control available work simulation participants completed trials inbox activity conditions low high work control ordering levels varied create increase decrease change work control support hypotheses results revealed self determined individuals high work control led increased use positive reappraisal follow moderated mediation analyses revealed increases positive reappraisal observed self determined individuals conditions work control high trial consequently increased intrinsic motivation toward task non self determined individuals high work control well changes work control led elevated anxiety follow moderated mediation analyses revealed increases anxiety observed non self determined individuals high high work control condition consequently reduced task performance concluded adjustment demanding work task depends fit individuals global motivation work control available consequences engagement demanding work
paper devoted problem fault detection analog electrical circuits described linear nonlinear polynomial models called data driven method fault detection considered method assumes parameters circuit consideration may unknown use methods identification allows checking whether parameters elements deviate considerably nominal values
women hunters significant portion hunting population north america increasing attention demographic group requires investigation analysis article introduces qualitative data investigate women hunters examining women hunt women hunt gender identities negotiated male dominated sport relationships men often introduced sport study suggests women use hunting way reinforce roles male relationships romantic familial friendly family also performing domestic gender roles providing food family recognizing culture motives women hunters paramount understanding women successfully pervade social space traditionally occupied men les chasseurs feminins sont une partie importante amerique nord population chasse attention croissante groupe demographique necessite une enquete une analyse plus approfondies cet article presente des donnees qualitatives pour enqueter sur les femmes chasseurs examinant comment les femmes chassent pourquoi les femmes chassent comment les identites genre sont negociees dans sport domine par les hommes leurs relations avec les hommes qui les ont souvent introduites sport cette etude suggere que les femmes utilisent chasse comme moyen renforcer leur role dans leurs relations masculines que soit romantique familiale amicale familiales tout effectuant les taches domestiques fournissant nourriture pour leur famille reconnaissant culture les motivations des femmes chasseurs est primordiale pour comprendre comment les femmes envahissent avec succes espace social traditionnellement occupe par des hommes
background neutrophils key effectors widely distributed mold aspergillus fumigatus major threat immunocompromised patients including allogeneic hematopoietic stem cell transplant hsct recipients yet little known neutrophil activity time cell transplantation especially regarding fumigatus objective aimed assessing activity neutrophils fumigatus allogeneic hsct recipients different posttransplantation time points methods performed longitudinal study involving patients undergoing hsct drawing blood samples engraftment months hsct posttransplantation neutrophil activity recipients compared respective donors neutrophil fumigatus coculture flow cytometry video microscopy used assess neutrophil inhibition fungal growth cell fungus interactions reactive oxygen species production major surface molecule expression neutrophil extracellular trap net formation results ability neutrophils interfere aspergillus species hyphal growth impaired hsct administration calcineurin inhibitors appeared play important role impairment also observed post hsct neutrophils produced less nets correlated increased fungal growth tapering immunosuppression led recuperation inhibition capacity months hsct conclusion hsct recipients neutrophil driven innate immunity fungi altered early posttransplantation period recovery neutropenia months alteration least partly related administration calcineurin inhibitors diminution nets production
context currently many service operations performed service oriented software engineering sose service composition discovery depend heavily quality service qos due factors varying loads real value dynamic qos attributes response time availability changes time however existing qos based studies approaches consider changes instead assumed rely unrealistic static qos information provided service providers may seriously impair outcomes objective predict dynamic qos values objective devise approach generate predictor perform qos forecasting based past qos observations method use genetic programming type evolutionary computing used search based software engineering sbse forecast qos attributes web services proposed approach used search evolve expression based one step ahead qos predictors evaluate performance accuracy based approach also implement current time series forecasting methods comparison approach methods discussed context real world qos data results compared common time series forecasting methods approach found suitable stable solution defined qos forecasting problem addition numerical results experiments also analyze provide detailed descriptions advantages benefits using perform qos forecasting additionally possible validity threats using approach validity sbse discussed evaluated conclusions paper thoroughly completely demonstrates realistic situation real world qos data proposed based qos forecasting approach provides effective efficient accurate forecasting considered instance sbse elsevier rights reserved
background breast cancer preventive behaviors extreme effect women health despite benefits preventive behaviors regarding breast cancer implemented routine care healthy women assess health issue reliable valid scale needed aim present study develop examine psychometric properties new scale called assists order identify factors affect women breast cancer prevention behaviors methods multi phase instrument development method performed develop questionnaire february september item pool generated based secondary analyses previous qualitative data content face validity applied provide pre final version scale scale validation conducted sample women recruited health centers affiliated tehran university medical sciences construct validity exploratory confirmatory convergent validity discriminate validity internal consistency reliability test retest analysis questionnaire tested results fifty eight items initially extracted secondary analysis previous qualitative data content validity reduced items exploratory factor analysis revealed seven factors attitude supportive systems self efficacy information seeking stress management stimulant self care containing items jointly accounted observed variance confirmatory factor analysis showed model appropriate fitness data cronbach alpha coefficient subscales ranged intraclass correlation coefficient icc ranged well acceptable thresholds conclusion findings showed designed questionnaire valid reliable instrument assessing factors affecting women breast cancer prevention behaviors used practice future studies
study examines time report following close maltreatment investigation cases involving food neglect data families children involved child protective services cps investigations merger cohort national survey child adolescent well nscaw national child abuse neglect data system ncands used half families history cps involvement third received cps services one ten families child place home care following investigation controlling types maltreatment allegations multiple covariates families investigated food neglect greater chance reported subsequent cps investigations shorter length time families without allegation food neglect small percentage families food neglect allegation problems adequately feeding child whether due severe poverty inattentiveness abusive negligence placed family higher risk future cps investigation elsevier ltd rights reserved
address particular cyber attack technique known stack buffer overflow gnu linux operating systems widely used hpc environments buffer overflow problem around quite time continues ever present issue develop mechanism successfully detect react whenever stack buffer overflow occurs solution requires compile time support applied program including legacy closed source software source code available makes especially useful hpc environments given complexity scope computing system incidents like overflows might difficult detect react accordingly authors published elsevier
background aged residents institutional long term care facilities high risk developing skin tissue diseases besides various common skin problems dry skin xerosis cutis one frequent skin conditions setting objectives investigate effectiveness two structured skin care regimens comparison routine skin care xerosis cutis nursing home residents design multi center pragmatic randomized controlled investigator blinded study three parallel groups settings study conducted random sample ten institutional long term care facilities federal state berlin germany participants long term care residents years affected dry skin included methods residents allocated one three study groups two interventional groups used standardized skin care regimens consisting body wash twice daily applications leave products eight weeks third control group performed skin care usual participating residents examined baseline weeks xerosis cutis measured overall dry skin score instrumental skin barrier measurements performed baseline weeks diaries used document washing skin care frequencies results total residents included allocated one three groups mean age years female residents care levels according german social code book mean barthel score mean braden score leg skin areas drier compared arms trunk areas end study overall dry skin scores intervention groups lower compared control group statistically significant improvements skin dryness intervention groups compared control group time conclusions results pragmatic trial indicate structured skin care regimens effective reducing skin dryness aged nursing home residents within eight weeks elsevier ltd rights reserved
paper self heating mutual thermal coupling state art sige multi finger heterojunction bipolar transistor hbt investigated static operation conditions multi finger hbt structure created using sentaurus structure editor dimensions similar layout sige multi finger hbts microelectronics bicmos technology ghz max ghz per bicmos process design kit guidelines three dimensional thermal technology computer aided design tcad simulations carried obtain temperature distribution static operation lattice temperature lattice heat flux heat distribution inside device studied impact back end line beol layers static thermal behavior state art sige multi finger hbts also investigated temperature dependent thermal resistance different fingers trench isolated sige multi finger hbt extracted without back end line beol effect electro thermal compact model self heating mutual thermal coupling multi finger hbts proposed applied compare modeling results tcad simulation results good agreement achieved results obtained tcad simulation obtained compact model based simulation
research develop method noninvasive fast blood glucose assay vivo near infrared nir spectroscopy promising technique compared methods investigated rats diabetes normal rats calibration models generated two different multivariate strategies partial least squares pls linear regression method artificial neural networks ann non linear regression method pls model optimized individually considering spectral range spectral pretreatment methods number model factors ann model studied individually selecting spectral pretreatment methods parameters network topology number hidden neurons times epoch results validation showed two models robust accurate repeatable compared ann model performance pls model much better lower root mean square error validation rmsep higher correlation coefficients elsevier rights reserved
green buildings gaining popularity australia applications green star rating scheme however credit using timber materials rating scheme timber significantly used material fast growing residential construction industry adequately guide designers builders selection best timber types residential applications life cycle perspective research presents analysis life cycle cost timber materials various applications residential buildings australia thereby provides guidance best meet requirement set timber credit green start rating scheme structured interviews used collect data cost timber materials lifetime builders tradesmen residential construction professionals three sets cost information received application individual timber species three conditions low medium extreme weather reference residential buildings based life cycle cost analysis results suitable timbers different applications recommended elsevier ltd rights reserved
graphics processing unit gpu applied successfully many computation memory intensive realms due superior performances float pointing calculation memory bandwidth power consumption great potential power system applications contingency screening major time consuming part contingency analysis absence relevant existing research paper first kind propose novel gpu accelerated algorithm direct current contingency screening adapting actively unique characteristics gpu software hardware proposed gpu algorithm optimized four aspects data transmission parallel task allocation memory access cuda compute unified device architecture stream case studies bus system bus system shown gpu accelerated algorithm compared counterpart cpu implementation achieve times speedup respectively highly promising performance demonstrated carefully designed performance tuning conjunction gpu programing architecture imperative gpu accelerated algorithm presented performance tuning strategies applicable gpu applications power systems elsevier ltd rights reserved
purpose purpose paper address relationship leader use nonverbal immediacy specific hand gestures followers attraction leader study provides initial evidence certain hand gestures effective others creating immediacy leaders followers design methodology approach experimental study participants male female shown one three videos actor leader using three positive hand gestures three defensive hand gestures hand gestures previously operationalized grouped arbitrarily experimenter three hypotheses tested using anova group gender main interactional effects findings independent variable positive hand gestures perceived participants immediate two independent variables defensive hand gestures hand gestures analysis data indicate participants perceived leaders hand gestures defensive hand gestures distant non immediate leader positive hand gestures immediate attractive research limitations implications study limited pilot study establishing differences specific hand gestures first time practical implications research provides initial evidence hand gestures arbitrarily defined positive create immediacy followers leader usage negative gestures gestures social implications current research act motivator leaders fast forward relationships followers use specific hand gestures originality value results suggest possibility hand gestures effective others
prostate specific membrane antigen psma targeting radioligand therapy rlt introduced first report described antitumor side effects single dose aim analysis evaluate toxicity antitumor activity single repetitive therapies thirty four men metastatic castration resistant prostate cancer received psma rlt mip twenty three patients received second three patients third dose timed psa progression initial response preceding therapy applied doses separated three groups gbq antitumor side effects analyzed blood samples clinical data follow conducted years best therapeutic effect achieved first therapy psa decline achieved patients second third therapies significantly less effective neither association applied activity psa response time progression hematologic toxicities less prevalent presented higher percentage patients increasing number therapies hematologic toxicities xerostomia second frequent side effect presented often higher intensity second third therapy first dose rlt mip presented low side effects could significantly reduce tumor burden majority patients second third therapies less effective presented frequent intense side effects especially hematologic toxicities xerostomia
work nanocomposites containing different amounts nanoclay prepared using corotating twin screw extruder practice hard task identify relationship extrusion process parameters tensile modulus nanocomposites performing several experiments one approach map relationship process parameters tensile modulus nanocomposites use non linear system identification tool called adaptiveneuro fuzzy inference system anfis study achieve high modeling accuracy generalization capability efficient shuffled frog leaping sfl algorithm proposed learn parameters network multi input single output miso anfis model constructed learned predict tensile modulus nanocomposites anfis model constructed trained tested based collection experimental data sets acceptable agreement observed experimental results predicted results proposed model statistical quality proposed model significant due good correlation coefficient values predicted values experimental ones training testing phase also comparison results indicate superior performance proposed scheme conventional reported methods due high approximation accuracy good generalization capability
due rapid data growth statistical analysis massive datasets often carried distributed fashion either several datasets stored separate physical locations relevant given problem simply achieve faster parallel computation divide conquer scheme cases challenge obtain valid inference require processing data single central computing node show widely used class spatial low rank models written linear combination spatial basis functions plus fine scale variation component parallel spatial inference prediction massive distributed data carried exactly meaning results traditional non distributed analysis communication cost distributed algorithms depend number data points extending results spatio temporal case illustrate methodology carrying distributed spatio temporal particle filtering inference total precipitable water measured three different satellite sensor systems
present study designed examine mothers emotional reactions causal attributions socialization strategies response preschool children engagement proactive reactive physical aggression peers free play school participants mothers age preschool aged children age residing ankara turkey supporting expectations mothers reacted negative emotions functions aggressive behaviours less anxiety disappointment embarrassment guilt reactive aggression also believed reactive aggression contextually dependent intentional reported indirect asking child teacher children find situation aggressive episode oriented strategies telling child behave properly address behaviours overall findings suggest turkish mothers feelings perceptions socialization approaches childhood aggression vary depending functions aggression mothers perceive preschool aged children engagement reactive aggression school setting relatively acceptable proactive aggression copyright john wiley sons ltd
clinical success mirabegron first adrenoceptor agonist treatment overactive bladder oab syndrome resulted substantial interest site mechanism action even adrenergic innervation bladder urethra well studied location ars different structures within bladder wall urethra mode action stimulation still established recent demonstration ars cholinergic nerve terminals immunoreactivity urothelium detrusor smooth muscle agreement previous morphological studies functional data strongly suggest ars found structures however recent studies suggest ars detrusor smooth muscle may functionally relevant assumption activation bladder filling inhibits acetylcholine release parasympathetic neurons prejunctional mechanism decreases bladder micromotions generate afferent activity attractive hypothesis exclude mechanisms may contributing supports combined approaches reduce afferent activity treatment oab syndrome
vitreoscilla filiformis gram negative bacterium isolated spa waters described beneficial effects skin characterized detailed structure lipopolysaccharide lps lipid moiety active component bacterium contributes observed skin activation properties two different batches differing postculture cell recovery tested chemical analyses mass spectra obtained mild alkali treatments revealed lipids share common bisphosphorylated beta linked glucosamine disaccharide hydroxydecanoic acid amide linkage short chain fas hydroxydecanoic dodecanoic acid found ratio two lipid structures differed relative amount hexa acyl molecular species phosphoethanolamine substitution phosphate groups two filiformis lps batches induced variable interleukin tnf secretion stimulated myelomonocytic thp cells without difference reactive oxygen species production activation caspase different well known highly purified lps samples characterized structurally used standards structural data obtained work explain low inflammatory response observed filiformis lps previously demonstrated beneficial effects skin
propose approximation possible worlds semantics pws knowledge support postdiction fundamental inference pattern diagnostic reasoning explanation tasks wide range real world applications cognitive robotics visual perception cognitive vision ambient intelligence smart environments present formal framework operational semantics analysis soundness completeness results therefrom advantage approach linear number state variables required represent agent knowledge state achieved modeling knowledge history single approximate state instead using exponential number possible worlds like kripke semantics add temporal dimension knowledge representation facilitates efficient postdiction since consider knowledge histories call theory approximation hpx due linear number state variables hpx features comparably low computational complexity specifically show hpx solve projection problem polynomial tractable time solve planning problems action language sigma complete addition temporal dimension knowledge theory supports concurrent acting sensing sense expressive existing approximations elsevier rights reserved
paper propose novel domain decomposition method large scale simulations continuum mechanics merging concepts centroidal voronoi tessellation cvt voronoi particle dynamics cvt introduced achieve high level compactness partitioning subdothains lloyd algorithm monotonically decreases cvt energy number computational elements neighboring partitioning subdomains scales communication effort parallel simulations optimized implicitly generated partitioning subdomains convex simply connected small aspect ratios moreover voronoi particle dynamics employing physical analogy tailored equation state developed relaxes particle system towards target partition good load balance since equilibrium computed iterative approach partitioning subdomains exhibit locality incremental property numerical experiments reveal proposed centroidal voronoi particle cvp based algorithm produces high quality partitioning high efficiency independently computational element types thus used wide range applications computational science engineering elsevier inc rights reserved
paper receding horizon optimization approach model identification oriented input design proposed practical application demonstrated internal combustion engines proposed approach consists recursive parameter identification algorithm input signal design algorithm latter provides optimal excitation signal adaptation parameter estimation following identification phase optimization algorithm constructed continuation gmres method provides approximate solution according current parameter model validate effectiveness feasibility proposed approach testing results applying proposed approach internal combustion engine demonstrated conducted full scale engine test bench elsevier inc rights reserved
introduction detailed comparative analysis effects direct current microcurrent point stimulation mps autonomic nervous system applied battlefield acupuncture bfa protocol patients histories pain methods evaluations entailed standard baseline visual analogue scale vas pain saliva cortisol baseline status autonomic nervous system ans functions total markers repeated prior following electrotherapy cohort patients results ans response microcurrent point electrical nerve stimulation reflected statistically significant pre post improvement markers collected pain vas scale reduced points confidence interval heart rate variability improved points high frequency vagal tone improved points exercise tolerance increased points parasympathetic activity improved points stress reduced points ptgi photoplethysmography index cardiac marker endothelial function arterial blood flow ans regulation improved points cardiac marker ptgvlfi photoplethysmography low frequency index ans regulation marker endothelial function indicator cell activity statistically significant reduction points salivary cortisol decreased points conclusions positive impressive results study showed significant improvement several parameters ans function reduction pain cortisol levels replicated study paves way use mps applied bfa protocol pathologies known affected sympathetic nervous system activation
drum driving system one weakest parts long wall shearer methods also needed monitor control long wall shearer adapt important trend unmanned operation future mining systems therefore essential conduct electromechanical dynamic analysis drum driving system long wall shearer first torsional dynamic model planetary gears proposed convenient connected electric motor model electromechanical dynamic analysis next electromechanical dynamic model drum driving system constructed including electric motor gear transmission system drum electromechanical dynamic characteristics simulated shock loads acted drum driving system finally advices proposed improving reliability monitoring operating state choosing control signals long wall shearer based simulation
introductionlow testosterone suggested risk factor peyronie disease may correlate disease severity low common men sexual dysfunction role pathogenesis remains unclear aimthe aim study compare prevalence low men low compared men levels correlate plaque size degree curvature group conclusionsmen sexual dysfunction characterized either similarly low levels low correlate severity surgical correction rate comparable prevalence low men suggests high rate low men may related common process among men abnormal erectile physiology specifically causative plaque formation kirby verges matthews carson coward low testosterone similar prevalence among men sexual dysfunction due either peyronie disease erectile dysfunction correlate peyronie disease severity sex med
objective aimed identify clinical genetic associations sacroiliitis patients psoriatic arthritis psa describe different radiographic patterns psa clinical genetic associations methods psa patients fulfilling caspar criteria underwent detailed skin rheumatologic assessments addition hla status recorded shown key genetic markers radiographic psa grade unilateral bilateral radiographic changes required inclusion involvement defined asymmetrical symmetrical results patients radiographic either present past history backache regression analysis demonstrated significant association peripheral joint erosions pasi maximum younger age psa onset presence hla marginal significance hla asymmetrical noted patients striking contrast patients symmetrical patients asymmetrical likely female trend towards severe nail disease peripheral joint erosions osteolysis hla positivity much less hla positivity conclusion psa developing younger age severe skin disease peripheral joint erosions hla significantly associated marginal trend towards significance hla hla positive axial psa patients resemble hla positive axial psa patients asymmetrical unilateral typical psa
although mindfulness plays important role treatment borderline personality disorder bpd studies investigated whether individuals bpd show difficulties mindfulness studies relied exclusively questionnaire data used objective behavioral assessment mindfulness difficulties bpd allowed distinguish difficulties mindfulness prolonged mind wandering difficulties awareness mind wandering twenty five individuals bpd healthy controls performed two mindful breathing tasks frequency mindfulness versus mind wandering assessed experimenter prompted mindfulness task participants interrupted random intervals asked whether mindful mind wandering awareness mind wandering assessed self prompted mindfulness task participants asked press computer key whenever noticed mind wandering length mind wandering assessed tasks individuals bpd found lower frequency mindful episodes addition individuals bpd indicated longer mind wandering episodes experimenter prompted task however individuals bpd detected mind wandering episodes accurately healthy controls self prompted task finally difficulties mindfulness observed behavioral tasks positively correlated participants reports mindfulness difficulties everyday life using behavioral tasks specify difficulties mindfulness bpd study indicated although individuals bpd mind wander longer often awareness mind wandering appear unaffected indicates mindfulness difficulties reported individuals bpd therapists build awareness mindfulness based treatments bpd
visual spatial working memory measures widely used clinical experimental settings furthermore argued male advantage spatial abilities explained sex difference visual spatial working memory therefore sex differences visual spatial working memory important implication research theory practice yet quantified present meta analysis quantified magnitude sex differences visual spatial working memory examined variables might moderate analysis used set effect sizes healthy males females drawn samples ranging mean age years multilevel meta analysis used overall data set account non independent effect sizes data also analyzed separate task subgroups means multilevel mixed effects models results showed small significant male advantage mean confidence interval tasks produced male advantage except memory location female advantage emerged age participants significant moderator indicating sex differences visual spatial working memory appeared first years age group removing memory location tasks sample affected pattern significant moderators present results indicate male advantage visual spatial working memory although age specific task modulate magnitude direction effects implications clinical applications cognitive model building experimental research discussed
article presents robotic dataset collected largest underground copper mine world sensor measurements scanning lidar radar stereo cameras recorded approximately two kilometer traverse production active tunnel equipment used data collection process discussed detail along format data dataset suitable research robotic navigation well simultaneous localization mapping download instructions available following website http dataset amtc
recently deep learning processors become one promising solutions accelerating deep learning algorithms currently method programming deep learning processors writing assembly instructions bare hands costs lot programming efforts causes low efficiency one solution integrate deep learning processors new back end one prevalent high level deep learning framework tpu tensor processing unit integrated tensorflow directly however obstruct frameworks profit programming interface alternative approach design framework independent low level library deep learning processors deep learning library gpu cudnn fashion library could conveniently invoked high level programming frameworks provides generality order allow deep learning frameworks gain benefits environment envision low level library could easily embedded current high level frameworks provide high performance three major issues designing library discussed first one design data structures data structures possible able support possible operations allow optimize data structures easier without compromising generality second one selection operations provide rather wide range operations support various types networks high efficiency third design api provide flexible user friendly programming model easy embedded existing deep learning frameworks considering issues propose dlplib tensor filter based library designed specific deep learning processors contains two major data structures tensor filter set operators including basic neural network primitives matrix vector operations provides descriptor based api exposed interface library achieves speedup compared performance hand written assembly instructions
many couples want retire together even spouses differ age drawing theories leisure complementarity gender roles social status article uses comprehensive swedish register data explore synchronised retirement association spousal age differences socio demographic factors synchronisation rates dual earner couples per cent retirement calendar year per cent retirement following year contrary theoretical expectations synchronisation common women older couples men older couples although largely consequence skewed distribution age differences moreover spouses education incomes assets employment health differently associated synchronisation age men older women older couples total population average retirement age differed little synchronising couples couples yet women synchronised retired earlier age women whereas men synchronised retired later men partly effect predominance men older couples men men older couples also likely women women older couples delay retirement order synchronise
paper focuses analyzing concepts green building green residential building analysis development state green residential building home abroad paper also studied current development trend green residential building prospects development development direction green residential building china put forward provide reference application green building
sexual risk behaviors place adolescents young adults risk sexually transmitted diseases stds unintended pregnancy therefore important study different populations order develop strategies aimed reduce risk behaviors help young people adopt lifelong attitudes promote health authors designed study order evaluate sexual contraceptive behavior portuguese female medical students existent information subject scarce results revealed low risk sexual behavior high use effective contraception despite utilization emergency contraception nearly one third students
recent years witnessed remarkable growth way mathematics informatics computer science process data disciplines machine learning pattern recognition computer vision computational neurology molecular biology information retrieval etc many new methods developed cope ever increasing amount complexity data new methods offer interesting possibilities processing classifying interpreting eye tracking data present paper exemplifies application topological arguments improve evaluation eye tracking data task classifying raw eye tracking data saccades fixations single simple well intuitive argument described coherence spacetime discussed hierarchical ordering fixations dwells shown method namely identification topological characteristics itop parameter free needs pre processing post processing raw data general robust topological argument easy expand complex settings higher visual tasks making possible identify visual strategies
image segmentation fundamental problem computer vision color texture information usually employed obtain satisfactory segmentation results however traditional color texture segmentation methods usually assume color based texture based segmentation results globally consistent always case sometimes color texture based segmentation results may worse single feature color texture based ones consistency constraints taken account inappropriately address problem graph cuts based color texture cosegmentation method proposed paper similarity constrains considered rather global consistencies penalty term included adaptively balance possible local inconsistencies additionally order extract texture features effectively comprehensive texture descriptor designed integrating nonlinear compact multi scale structure tensor ncmsst total variation flow flow large number segmentation comparison experiments using synthesis color texture images real natural scene images verify superiorities proposed texture descriptor color texture cosegmentation method elsevier rights reserved
excessive grasper force may lead irrevocable damage tissue minimally invasive surgery study focuses grasping mechanism laparoscopic surgery tool order control grasping force first dynamics grasping mechanism conventional laparoscopic grasper investigated using analytical experimental methods smart laparoscopic surgery tool designed using shape memory alloy wire bias spring grasper force controlled actuator different type controllers performance controllers compared closed loop dynamics grasper mechanism achieved overshoot zero steady state error elsevier ltd rights reserved
bulimia nervosa characterized symptoms binge eating compensatory behavior overevaluation weight shape often occur symptoms anxiety depression however little research identifying specific symptoms maintain psychopathology associated symptoms depression anxiety network analyses represent emerging method psychopathology research examine symptoms interact may become self reinforcing current study adults diagnostic statistical manual mental disorders fourth edition dsm diagnosis used network analysis identify central symptoms well symptoms may bridge association symptoms anxiety depression symptoms results showed fear weight gain central psychopathology whereas binge eating purging restriction less central symptom network symptoms related sensitivity physical sensations changes appetite feeling dizzy wobbly identified bridge symptoms anxiety depressive symptoms discuss findings respect cognitive behavioral treatment approaches findings suggest treatments focus fear weight gain perhaps exposure therapies interventions focusing exposure physical sensations may also address psychopathology well occurring anxiety depressive symptoms
structure driven properties vanadium oxide inspired enormous developments last decades especially smart material energy sensors optoelectronics large variety stable metastable structures vanadium oxide discussed based calculated formation energies broad overview structure related properties established chemical deposition processes gas phase reviewed particular emphasis implemented precursors obtained vanadium oxide phases although significant fraction relevant vanadium oxide compounds achieved methods still rewarding challenges related controlled elaboration investigation responsive properties
absolute stability attracted much attention several stability conditions loops slope restricted nonlinearities developed results circle criterion popov criterion form part core curriculum students control moreover equivalence results obtained different techniques specifically lyapunov popov stability theories led one important results control engineering kyp lemma luryel systems work culminated class multipliers proposed shea formalized zames falb superiority class quickly widely accepted nevertheless result ahead time graphical techniques preferred absence readily available computer optimization first systematic use stability criterion came years initial proposal class years required develop proper understanding different techniques used long gestation significant knowledge overlooked forgotten significantly shea contribution insight longer acknowledged papers barely cited despite original parameterization class tutorial paper aims provide clear comprehensive introduction topic user viewpoint review main results stability theory properties multipliers including phase properties phase equivalence results issues associated causality convex searches clarity exposition restrict attention continuous time multipliers single input single output results nevertheless include several recent significant developments authors others illustrate topics using example proposed shea european control association published elsevier ltd rights reserved
present novel sensor system support nutrition monitoring system based smart table cloth equipped fine grained pressure textile matrix weight sensitive tablet unlike many nutrition monitoring approaches system unobtrusive non privacy invasive easily deployable every day life allows spotting recognition food intake related actions cutting scooping stirring etc identification plate container action executed tracking weight change containers words determine many pieces cut main dish plate many taken side dish many sips taken drink fast food consumed much weight taken overall addition distinction different eating actions cutting scooping poking provides clues type food taken way meal consumed evaluated system meals subjects real life living environment seven eating related actions cutting scooping stirring etc resulting average recognition rate person dependent cases spotting action continuous data streams average score
perfluoroalkyl acids pfaas ubiquitous chemicals extremely resistant widespread throughout environment frequently detected human blood samples animal studies revealed exposure pfaas results immunotoxicity however association pfaas especially long chain pfaas allergies humans well established examined whether prenatal exposure pfaas associated allergic diseases among year old children large scale prospective birth cohort hokkaido japan total mother child pairs included study prenatal levels eleven pfaas measured maternal plasma samples obtained weeks pregnancy using ultra performance liquid chromatography tandem mass spectrometry participant demographic characteristic information obtained self administered pre postnatal questionnaires medical birth records infant allergies assessed using japanese version international study asthma allergies childhood isaac phase three questionnaire administered years post delivery symptoms included eczema wheezing rhinoconjunctivitis prevalence respectively associations pfaa quartiles allergic outcomes examined using logistic models adjusted odds ratios ors quartile quartile total allergic diseases including least one allergic outcome significantly decreased perfluorododecanoic acid pfdoda confidence interval andperfluorotridecanoic acid pftrda children obtained similar results examining association pfaas eczema adjusted wheezing relation higher maternal pfhxs levels children conclusion prenatal exposure long chain pfaas pfdoda pftrda may immunosuppressive effect allergic diseases year old children published elsevier ltd
novel replacement traditional wedgelocks used mount pcb boards cold plates presented project began part darpa design competition develop field reversible thermal connector could repeatedly assembled disassembled without use tools providing constant thermal resistance team ucla tasked designing new device meet constraints design meets darpa goals significantly reduces thermal resistance electrical board heat sink device consists opposing aluminum wedges driven thermally actuated nitinol springs slide one another provide requisite locking force hold board place decrease contact resistance interfaces smart material springs push wedges towards outside device elevating upper surface locking board place cold plate design increases contact area components decreases thermal resistance relative current devices experimental results shown ucla team addressed chief design problems posed revcon program nitinol shown effective material use thermally actuated spring capable repeatedly engaging disengaging without use tools wedge locking force increases rising temperature enhancing thermal performance ucla design shown perform similar sized current state art wedgelock designs terms thermal resistance reductions thermal resistance demonstrated shown repeatable prototype design increases interfacial contact area dramatic impact performance means higher power density electronics utilized real estate made available current computer boards order maintain current performance use thermally actuated leaf springs removes need mechanical force installation allowing less installation time
although vision based methods displacement vibration monitoring used civil engineering decade techniques require physical targets attached structures requirement makes computer vision based monitoring real life structures cumbersome due need access certain critical locations study non target computer vision based method displacement vibration measurement proposed exploring new type virtual markers instead physical targets key points measurement positions obtained using robust computer vision technique named scale invariant feature transform show potential ability take place classical targets calculate converting ratio pixel based displacement engineering unit millimetre practical camera calibration method developed convert pixel based displacements engineering unit since calibration standard target available methods approaches handle challenges low contrast changing illumination outliers matching key points also presented proposed method verified demonstrated ucf four span bridge model real life structure excellent results static dynamic behaviour two structures finally method requires simple less complicated cost effective hardware compared conventional displacement vibration monitoring measuring technologies
background objective sleep disturbance common problem among adults obesity mindfulness interventions shown improve sleep quality various populations investigated adults obesity aim study compare effects mindfulness based weight loss intervention active control self reported sleep quality among adults obesity method study secondary analysis randomized controlled trial included adults body mass index range treatment intervention included mindfulness based eating stress management practices active control intervention included training progressive muscle relaxation pmr groups received identical diet exercise guidelines group sessions conducted months matched time attention social support primary outcome analysis group change self reported sleep quality assessed using pittsburgh sleep quality index psqi global score baseline months results group differences mean psqi change scores mindfulness group compared control group months months months direction sleep improvement mindfulness group none reaching statistical significance mindfulness group average weekly minutes meditation practice time associated improved sleep quality baseline months conclusions statistically significant evidence found weight loss program incorporates mindfulness improves self reported sleep quality compared control diet exercise intervention included pmr within mindfulness group average weekly minutes mindfulness practice associated improved sleep quality
extensive utilization wireless sensor networks wsns shm systems promotes optimal wireless sensor placement owsp important topic paper theoretical framework owsp shm presented within framework energy aware wireless sensor placement formulated discrete optimization problem linear independence identified mode shapes achieved connectivity wsn guaranteed energy efficiency entire wsn pursued hybrid discrete firefly algorithm hdfa developed solve complex optimization problem one dimensional binary coding system hamming distance adopted characterize fireflies distinguished optimization mechanism basic applied owsp problem hybrid movement scheme including directive movement nondirective movement proposed improve convergence speed enhance capability searching global optimization avoid falling local optimum hdfa applied long span suspension bridge verifications two optimization methods simple discrete simple genetic algorithm also employed facilitating comparisons results demonstrate hdfa extract optimal wireless sensor configuration highly linear independence identified mode shapes outstanding wsn performance combination directive movement nondirective movement proves hdfa outperform simple discrete simple genetic algorithm terms computational efficiency superiority results copyright john wiley sons ltd
objectives examine relationships location demographics lifestyle beliefs experience hot flushes night sweats hfns amongst women living two cities thailand methods cross sectional study peri postmenopausal women aged years bangkok chiang mai participants completed questionnaires demographics health hfns prevalence frequency problem rating beliefs menopause sub sample women location interviewed results total women bangkok chiang mai aged standard deviation years took part prevalence hfns average hfns frequency per week problem rating women chiang mai significantly problematic hfns prevalence frequency similar sites poor general health predicted hfns prevalence frequency chiang mai location hfns frequency age diet beliefs menopause associated problematic hfns location remained significant controlling education occupation age location partially explained beliefs qualitative interview responses illustrated differences beliefs menopause locations conclusion hfns reports prevalent moderate frequency problem ratings urban centers thailand results included broader international menopause society study climate altitude temperature ims cat impact climate hfns
background incidence inflammatory bowel disease ibd increases thus common pregnant women ibd risk factor venous thromboembolism vte clear whether ibd predisposes women excess risk vte pregnancy postpartum period methods nationwide population based cohort study deliveries denmark using data two nationwide health registries danish national patient registry medical birth registry computed incidence rates irs per person years crude adjusted relative risks rrs confidence intervals cis vte pregnancy first postpartum weeks women without ibd results included women deliveries identified vte events pregnancy vte events postpartum vte pregnancy ibd patients women without ibd corresponding adjustment maternal age smoking pregnancies yielded adjusted ibd flare associated vte pregnancy postpartum vte among ibd patients women without ibd corresponding adjusted conclusions ibd risk factor vte pregnancy postpartum
background aspirin used concurrent anticoagulation increases risk gastrointestinal bleeding gib therefore multisociety guidelines recommend prophylactic proton pump inhibitors ppis patients receiving aspirin anticoagulation aimed determine rates predictors adherence recommendations methods adult inpatients discharged hospital aspirin anticoagulation july june retrospectively evaluated ppi prescription discharge instructions used univariate multivariate logistic regression test predictors ppi prescription results total patients discharged aspirin anticoagulation mean age years male prescribed ppi discharge univariate analysis factors associated discharge ppi prescription included increased age versus white race versus higher aspirin dose versus married versus preadmission ppi use versus multivariate analysis significant predictors discharge ppi prescription age years odds ratio years preadmission ppi use lower odds discharge ppi prescription included medicaid medicare insurance spanish language lower dose aspirin conclusions total patients discharged aspirin anticoagulation prescribed ppis older age preadmission ppi use predictive ppi prescription medicaid medicare insurance spanish language lower dose aspirin decreased likelihood discharge ppi prescription creates opportunity improve primary gib prevention quality improvement interventions
high speed spindle machines widely applied versatile areas manufacturing automotive industry food industry aviation commercial medical technology machine tools fuel cell turbo generator mixers spin testers food processor precise control energy saving spindle motor design implementation efficient electric spindle motor drive becomes important issue paper presents two different switching techniques inverter design one degrees conduction transistor turns period degrees six switching transistors inverter degrees conduction turns degrees complete cycle comparison two different switching techniques shows advantages degrees conduction switching inverter design utilization voltage degrees conduction higher degrees conduction mode complete system design electric motor drive based embedded system spindle motor including hardware design software programming described realized paper finally prototype spindle motor drive using arm microcontroller implemented demonstrated performances switching techniques also discussed
dietary management hailed effective strategy management irritable bowel syndrome specifically diet low fermentable carbohydrates fodmaps demonstrated efficacy approximately patients evidence support low fodmap diet continues emerge increasing debate regarding implementation diet particularly concerning educate patients educate registered dieticians largely pioneered evidence supports effectiveness low fodmap diet irritable bowel syndrome diet recognized dietician led therapy however increasing trend non dietician led implementation diet despite absence evidence clinical cost effectiveness additionally growing requirement dietetic services increase capacity response increasing referrals consequently need investigate innovative ways educate patients whilst maintaining dieticianled intervention herein review evidence delivery low fodmap diet discuss potentially effective methods service delivery
introductionpharmacists extended opening hours located communities many offer sexual reproductive health services emergency contraception opportunity receive injectable contraception community pharmacists would improve availability method might increase uptake continuation self administered survey women attending large urban sexual reproductive health clinic undertaken determine acceptability receiving contraceptive injections community pharmacist methodswomen aged years attending nhs walk sexual reproductive health clinic invited complete questionnaires waiting attend appointment clinician questionnaires asked women current previous never users progestogen injectable method contraception whether availability injectable local pharmacist would influence decision use method resultstwo hundred forty questionnaires distributed completed total respondents past users injectable current users remaining never users current non users indicated would consider using method available pharmacy main perceived advantages attending pharmacy quicker appointments easier access conclusionprovision injectable contraceptive pharmacist might make method attractive almost one three women currently using could strategy improve uptake continuation method
purpose study evaluate transfer learning deep convolutional neural networks classification abdominal ultrasound images grayscale images consecutive clinical abdominal ultrasound studies categorized categories based text annotation specified technologist image cropped images rescaled resolution randomized images studies constituting training set images studies constituting test set fully connected layers two convolutional neural networks based caffenet vggnet previously trained large scale visual recognition challenge data set retrained training set weights convolutional layers network frozen serve fixed feature extractors accuracy test set evaluated network radiologist experienced abdominal ultrasound also independently classified images test set categories caffenet network classified test set images accurately images top accuracy images larger vggnet network classified test set accurately images top accuracy vggnet images radiologist classified test set images correctly images differences classification accuracies neural networks radiologist statistically significant results demonstrate transfer learning convolutional neural networks may used construct effective classifiers abdominal ultrasound images
among occurring conditions autism spectrum disorders asd sleep disorders may exacerbate associated behavioral disorders lead intensification existing autistic symptoms several studies investigating use melatonin treatment sleep disorders asd shown comparative efficiency sleep little side effects report case asd non hour rhythm effect melatonin circadian parameters actigraphy visual analysis first days recorded periodogram suggest patient showed non hour rhythm asd subject showed melatonin administration activity rest rhythm lower hours results show melatonin increased approximately times regularity circadian activity rhythm resting staying average showed positive effects improving quality sleep behavior actigraphy showed asd subject non hour activity rest rhythm changed rhythm hour rhythm melatonin administration result reinforces prospect therapy melatonin synchronization increased regularity endogenous rhythms improve sleep quality hence behavior indicates actigraphy choice tool characterize several parameters activity rest rhythm asd individuals
background numerous studies highlighted elevated degree comorbidity associated autism spectrum disorder asd comorbid conditions may add impairments individuals autism substantially prevalent compared neurotypical populations high rates comorbidity surprising taking account overlap symptoms asd shares pathologies research perspective suggests common molecular mechanisms involved conditions therefore identifying crucial genes overlap asd comorbid disorders may help unravel common biological processes involved ultimately shed light understanding autism etiology results work used two fold systems biology approach specially focused biological processes gene networks conduct comparative analysis autism frequently comorbid disorders order define multi disorder subcomponent asd predict new genes potential relevance asd etiology validated predictions determining significance candidate genes high throughput transcriptome expression profiling studies using prior knowledge disease related biological processes interaction networks disorders related autism identified set genes previously linked asd significantly differentially regulated individuals autism addition genes potential etiologic relevance autism given enriched roles neurological processes crucial optimal brain development function learning memory cognition social behavior conclusions taken together approach represents novel perspective autism point view related comorbid disorders proposes model prior knowledge interaction networks may enlighten focus genome wide search autism candidate genes better define genetic heterogeneity asd
study investigates dynamic verbal non verbal communication context animal assisted therapy children special needs using ethological sociometrical methods focal individual sampling ethogram sequential behavior analysis study followed evolution year old boy mild mental retardation adhd symptoms low level verbalization one year weekly aat dog assisted therapy sessions session average duration min behavioral analysis video recorded materials indicated significant progress speech development decrease hyperactive symptoms implementation proposed methods focal animal sampling social network analysis allowed objectively analyze complex interactions behavioral sequences usually difficult extracted quantitative manner results supported hypotheses terms complexity verbal communication increased throughout five sessions dog assisted therapy selected behavioral data analysis nonverbal communication towards dog handler also diversified towards last session published future academy
objective aim study evaluate whether climacteric symptoms related urinary incontinence postmenopausal women methods cross sectional investigation performed postmenopausal women attending outpatient service menopause university hospital data regarding climacteric symptoms evaluated greene climacteric scale objective pelvic floor defects type retrieved electronic database additional information retrieved age anthropometric measures personal reproductive history use medication drugs smoking state anxiety state trait anxiety inventory scale score depression zung scale score results score greene climacteric scale higher women without true considering stress urge mixed multiple logistic regression models greene climacteric score independently related odds ratio along presence bladder prolapse age menopause previous hysterectomy women fourth quartile greene climacteric scale score conclusions postmenopausal women higher symptom burden captured greene climacteric scale relates underlying mechanisms assessed deserve investigation
due ability eliminate visual ambiguities single shot algorithms video based person identification received increasing focus computer vision visual ambiguities caused variations view angle lighting occlusions make identification problem extremely challenging overcome ambiguities previous approaches often extract robust feature representations learn sophisticated feature transformation however approaches ignore effect impostors arising annotation tracking process case impostors regarded genuine applied training process leading model drift problem order reduce risk model drifting propose automatically discover impostors multiple instance metric learning framework specifically propose knn based confidence score evaluate much impostor invades interested target utilize prior framework meanwhile integrate impostor rejection mechanism multiple instance metric learning framework automatically discover impostors learn semantical similarity metrics refined training set experiments show proposed system performs favorably state art algorithms two challenging datasets ilids vid prid improved rank recognition rate ilids vid prid dataset respectively elsevier ltd rights reserved
historical clinical recent preclinical data suggest muscarinic acetylcholine receptor exciting target treatment alzheimer disease cognitive negative symptom clusters schizophrenia however early drug discovery efforts targeting orthosteric binding site failed afford selective activation efforts shifted focus selective activation via either allosteric agonists positive allosteric modulators pams pams robust efficacy rodent models chemotypes induce cholinergic adverse effects aes could limit clinical utility report studies aimed understanding subtle structural pharmacological nuances differentiate efficacy adverse effect liability within indole based series ago pams data demonstrate closely related pams display striking differences vivo activities especially propensities induce adverse effects report discovery novel pam series devoid observable adverse effect liability interestingly molecular pharmacology profile novel pam similar representative pam induces severe aes instance compounds potent ago pams demonstrate significant interaction orthosteric site either bitopic negative cooperativity however subtle differences efficacies compounds potentiating responses agonist potencies abilities induce receptor internalization differences may contribute differential vivo profiles compounds vitro differences relatively subtle highlight complexities allosteric modulators need focus vivo phenotypic screening identify safe effective pams
introduction peripheral blood mononuclear cells pbmcs extensively used culture model generate osteoclasts vitro aim study assess osteoclastogenic potential pbmcs derived post menopausal women longstanding osteoporosis compare pbmcs healthy controls material methods selected population based rotterdam study participants diagnosed osteoporosis score lumbar spine presence least fracture healthy controls score fracture pbmcs differentiated osteoclasts differentiation capacity activity measured total rna obtained assess gene expression osteoclast markers deoxypyridinoline dpd measured plasma marker bone resorption vivo results neither number osteoclasts cathepsin ctsk dendritic cell specific transmembrane protein tmsf gene expression significantly different groups also significant difference resorption pit area plasma dpd levels stratification fracture type group vertebral non vertebral vertebral non vertebral fractures showed difference osteoclast formation osteoclastic bone resorption however plasma dpd rna expression markers significantly lower group subjects vertebral fracture group vertebral non vertebral fractures compared healthy controls differences osteoclastogenesis osteoclastic resorption plasma dpd levels detected also exclusion past present users bisphosphonates glucocorticoids stratification high low dpd levels showed higher osteoclastogenesis osteoclastic bone resorption high dpd group compared low dpd levels within group osteoporotic subjects conclusion study showed difference pbmc osteoclastogenic capacity activity women without osteoporosis least one previous fracture average years menopause suggesting difference circulating osteoclast precursors although exclude circulating precursors may behave differently bone site possible long menopause stable phase bone turnover reached compared earlier start menopause differences circulating osteoclast precursors osteoclastogenic potential prominent elsevier inc rights reserved
atopic dermatitis biphasic inflammatory skin disease provoked epidermal barrier defects immune dysregulation increased skin infections previously demonstrated bvpla evoked immune tolerance inducing regulatory cells treg thus alleviated dominant allergic asthma mice would like determine whether treatment bvpla exacerbates like allergic inflammations induced house dust mite extract dfe murine model epidermal thickness immune cell infiltration serum immunoglobulin cytokines measured ear swelling skin lesions levels total serum ige cytokines elevated dfe dncb induced mice topical application bvpla elicited significant suppression increased symptoms including ear thickness serum ige concentration inflammatory cytokines histological changes furthermore bvpla treatment inhibited mast cell infiltration ear hand treg cell depletion abolished anti atopic effects bvpla suggesting effects bvpla depend existence tregs taken together results revealed topical exposure bvpla aggravated atopic skin inflammation suggesting bvpla might candidate treatment
proteomics comprehensive analysis protein complement cell tissue biological fluid given time enabled quantum leaps mass spectrometric technology allowed identification large involatile biomolecules last two decades discipline evolved sole delivery protein identities platform reveals clues function characterisation protein modifications interactions well quantitative proteomics global comparison protein amounts two defined biological states proteomics integral part key player family omic disciplines genomics gene analysis transcriptomics gene expression analysis metabolomics metabolite profiling considering complexity dynamics protein concentration range given proteome proteomics challenging omic discipline requires sophisticated analysis pipeline proteomics represents established technology pharmaceutical industry mainly biomarker drug target discovery potential proteomics research food industry increasingly recognised employment proteomic approaches nutrition health issues emerging review summarizes major technological achievements mass spectrometry proteomics deliverables proteomics context nutrition health iii applications proteomics appropriate transcriptomics research fields digestive health obesity diabetes immunity allergy probiotics milk food preference
educational systems incorporating official curricula new knowledge related computational thinking education authorities consider economic labor educational social cultural arguments introduce computer programming curriculum compulsory education article describes analyzes three curricular designs include computational thinking one hand two prescriptive curricula autonomous community madrid organized around subjects focusing mandatory content standardized assessment moreover innovative globalized curriculum including computational thinking basic transversal contextual skill analysis designs observe two different approaches introduction programming classroom concludes need base curriculum design accumulated experience educational use computational thinking papert results educational research new learning ecologies
secure two way identity authentication scheme wifi environment raised perspective security load capacity mobile terminal according increasing serious wireless network security scheme based one time password authentication technology digital signature realized using elliptic curve cryptosystem known scheme resist common network attacks analyzing security scheme suitable application wifi environment high security requirements
article deals one major issues russian economy steps towards import substitution key russian industries research aimed elaborate methodological approach import substitution russian federation industry main methods used research complex analysis system analysis enable reveal system local problems import substitution uncover relations interdependence management subjects elements companies import substituting industries develop methodological toolkit problem solving article methodological approach organizing import substituting industry developed index evaluating competitiveness import substituting production introduced based research industrial companies findings article useful scholars interested foreign trade specialists industrial sector dealing production processes based import substitution
niemann pick type npc disease fatal neurodegenerative disorder caused bymutations npc npc decreased functions leading lysosomal accumulation cholesterol sphingolipids fty fingolimod used treatment ofmultiple sclerosis phosphorylatedby nuclear sphingosinekinase andits active phosphorylated form fty inhibitor class histone deacetylases study administration clinically relevant doses fty mice increased expression npc brain liver decreased cholesterol sphk dependent manner fty greatly increased expression npc human npc mutant fibroblasts correlated formation fty significantly reduced accumulation cholesterol glycosphingolipids agreement finding fty pretreatment human npc mutant fibroblasts restored transport cholera toxin subunit binds ganglioside golgi apparatus together findings suggest fty administration ameliorate cholesterol sphingolipid storage trafficking defects npc mutant fibroblasts neurodegeneration main clinical feature npc disease andfty accumulates thecnsandhas several advantages availablehistonedeacetylase inhibitors clinical trials work provides potential opportunity treatment incurable disease newton hait maceyka colaco maczis wassif cougnoux porter milstien platt platt spiegel fty fingolimod increasesnpc andnpcexpression reduces cholesterol sphingolipid accumulation niemann pick type mutant fibroblasts faseb www fasebj org
iso octane trimethylpentane primary reference fuel important component gasoline fuels moreover key component used surrogates study ignition burning characteristics gasoline fuels paper presents updated chemical kinetic model iso octane combustion specifically thermodynamic data reaction kinetics iso octane assessed based new thermodynamic group values recently evaluated rate coefficients literature adopted rate coefficients either experimentally measured determined analogy theoretically calculated values furthermore new alternative isomerization pathways peroxy alkyl hydroperoxide ooqooh radicals added reaction mechanism updated kinetic model compared new ignition delay data measured rapid compression machines rcm high pressure shock tube experiments conducted pressures atm equivalence ratios temperatures range updated model compared shock tube ignition delay times jet stirred reactor oxidation speciation data premixed laminar flame speeds counterflow diffusion flame ignition shock tube pyrolysis speciation data available literature finally updated model used investigate importance alternative isomerization pathways low temperature oxidation highly branched alkanes compared available models literature present model represents current state art fundamental thermochemistry reaction kinetics iso octane thus provides best prediction wide ranging experimental data fundamental insights iso octane combustion chemistry combustion institute published elsevier inc rights reserved
glycerol xylitol hydrate skin improve barrier function short period studied effects glycerol xylitol physiological properties morphology skin longer term application twelve volunteers dry skin examined three areas arms determined area served untreated control vehicle applied area area treated twice daily formulation containing glycerol xylitol days transepidermal water loss tewl hydration biomechanical properties skin monitored biopsies taken routine histology immunohistochemistry filaggrin matrix metalloproteinase mmp polyols increased skin hydration protein quantity filaggrin elevated interdigitation index decreased tewl improved biomechanical properties skin change protein expression mmp combination glycerol xylitol useful additional therapy dry skin
objective investigate adverse event free admissions potential patient centered indicator aligned directly goal patient safety freedom harm background preventable adverse event rates healthcare could reduced generally measured separately one adverse event time however reveal whether different patients affected patients experiencing multiple events methods examined medicare inpatient hospital administrative datasets processed using standard criteria events death within days unplanned readmissions within days iii long length stay healthcare acquired infections established patient safety indicators present admission defined adverse event free admissions without record events national rates calculated diagnosis group risk adjusted hospital specific rates adverse event free admissions calculated using colorectal procedures example results admissions exclusions approximately went acute inpatient medicare system without record anything untoward multiple events recorded admissions experienced adverse events risk adjusted hospitalspecific rates adverse event free admissions colorectal procedures showed hospitals lower control limit national upper quartile conclusions overall admissions recorded adverse event free multiple adverse events common even events recorded measure could provide easily understandable useful baseline clinicians managers
national international guidelines address stepwise atopic dermatitis management wet wrap therapy wwt important acute therapeutic intervention treatment moderate severe using clothing instead bandages makes intervention simpler less time intensive less expensive education patients caregivers critical success methodology must standardized future studies must carefully describe procedure components incorporation validated outcomes tools would help interpretation wwt considered potential treatment option ahead systemic immunosuppressive therapies patients failing conventional therapy
fully digital nonlinear wide bandwidth current controller voltage source converters presented paper exploiting sampling controller mimics analog hysteresis current controller employ analog comparators digital analog converters analog signal pre postprocessing circuitry indeed fully virtualizes hysteresis controller operation based nonlinear efficient current error processing algorithm drives power converter almost constant switching frequency overall offers excellent dynamic performance analog hysteresis controller time solves related problems current error sample processing algorithm inherently parallel structure controller suited vhdl synthesis field programmable gate array implementation guarantees flexibility low cost together minimum computation signal conversion delays intended application areas include active filters uninterruptible power supplies microgrid distributed energy resource controllers laboratory battery testers welding machines
seasonal affective disorder sad major depressive disorder recurs fall winter day length gets short well accepted day length encoded principal circadian clock located suprachiasmatic nucleus scn little known day length encoding diurnal mammals present study utilized grass rat arvicanthis niloticus investigate circadian system responds photoperiodic changes diurnal mammal shows day length dependent mood changes animals initially housed equatorial day length followed either long short photoperiods animals showed expansion peak phase per per rhythm scn well extended behavioral active phase contrast animals show compression active phase change peak duration per per expression compared results suggest circadian system diurnal grass rats less responsive day length gets short compared gets longer depression like behaviors assessed using sweet solution preference ssp forced swimming test fst animals group showed decreased ssp increased immobility time fst compared group suggesting depressive phenotype present study serves first step toward exploring role circadian system plays sad using diurnal rodent model ibro published elsevier ltd rights reserved
study investigated acute effects oxytocin human aggression using well established laboratory measure state reactive aggression test hypothesis would decrease frequency aggressive responding within subject design healthy male volunteers received placebo intranasal aggression measured using point subtraction aggression paradigm min min dose acute produce significant main effect aggressive behavior attenuated expected rise diastolic blood pressure morning early afternoon observed placebo providing possible indication biological activity examination individual differences showed aggressive responding following dosing placebo positively correlated psychometric measures interpersonal manipulation anger pearson indicating higher scores antisocial personality traits related increased aggressive behavior following administration preliminary results stand contrast previous work prosocial effects highlight need understanding individual differences aggression following administration individual differences may implications therapeutic use individuals psychiatric disorders dysfunctional social behavior copyright wolters kluwer health inc rights reserved
examine several methodological considerations eliciting probabilistic expectations developing country context using longitudinal ageing study india lasi conclude although average individuals able understand concept probability responses sensitive framing effects versus hypothetical person effects find overall people pessimistic survival probabilities compared state specific life tables socioeconomic status influence beliefs survival expectations found previous literature countries higher levels education income positive association survival expectations associations persist even conditioning self reported health results remain robust several alternative specifications compare survival measures objective measures health find activities daily life height low hemoglobin levels covary subjective expectations expected directions
emerging cloud applications growing rapidly need identifying managing service requirements also highly important critical present software engineering information systems established techniques methods technology two decades help achieve cloud service requirements design development testing however due lack understanding software security vulnerabilities identified managed requirements engineering phase successful applying software engineering information management requirements management principles established past least years developing secure software systems therefore software security added system built delivered customers seen today software applications paper provides concise methods techniques best practice requirements engineering management emerging cloud service ssremaaes also provides guidelines software security service paper also discusses integrated secure sdlc model sdlc benefit practitioners researchers learners educators paper illustrates approach large cloud system amazon service elsevier ltd rights reserved
psychosis alzheimer disease represents distinct clinical neurobiological phenotype associated rapid cognitive decline higher rates abnormal behaviors increased caregiver burden compared without psychosis molecular level associated greater reductions protein kalirin guanine exchange factor also linked psychotic disease schizophrenia study sought determine molecular behavioral consequences kalirin reduction appswe psende mice evaluated mice without kalirin reduction tasks measuring psychosis associated behaviors spatial memory found kalirin reduction appswe psende mice significantly attenuated psychosis associated behavior months age without changing spatial memory performance month old appswe psende mice reduced kalirin levels also increased levels active phosphorylated forms protein cdc rac eactivated kinases paks function signaling pathways maintenance dendritic spine density morphology function published elsevier inc
interactive image segmentation remained active research topic image processing graphics since user intention incorporated enhance performance employed mobile devices allow user interaction input enabling various applications interactive segmentation methods assume initial labels correctly carefully assigned parts regions segment inaccurate labels foreground labels background regions example lead incorrect segments even small number inaccurate labels appropriate practical usage mobile application paper present interactive segmentation method robust inaccurate initial labels scribbles address problem propose structure aware labeling method using occurrence occurrence probability ocp color values initial label unified framework occurrence probability captures global distribution color values within label occurrence one encodes local distribution color values around label show nonlocal regularization together ocp enables robust image segmentation inaccurately assigned labels alleviates small cut problem analyze theoretic relations approach segmentation methods intensive experiments synthetic manual labels show approach outperforms state art elsevier ltd rights reserved
order improve quality human living working environment different types wood structure building ecological architecture green building advocated due lots advantages study compared three types houses different weather conditions people psychological physiological indexes results showed temperature electrocardiograph heart rate respiratory rate people different types housing environment different physiological indexes structural glued laminated wood structure environment better steel concrete structure environment physiological indexes structural glued laminated environment better timber structure environment means subjects test easy comfortable relaxed feeling glued laminated timber structure environment provided theoretical support use product scientific efficient ways guidance design application construction wooden structure environment future
endocrine disrupting chemicals edc received considerable attention potential obesogens past studies examining obesogenic potential one widespread edc bisphenol bpa generally focused metabolic adipose tissue effects however physical inactivity proposed leading cause obesity paucity studies considered whether edc including bpa affects behavior test whether early exposure bpa ethinyl estradiol estrogen present birth control pills results metabolic behavioral disruptions california mice developmentally exposed bpa tested adults energy expenditure indirect calorimetry body composition echomri physical activity measured beam breaks voluntary wheel running serum glucose metabolic hormones measured differences body weight food consumption detected bpa exposed females exhibited greater variation weight females control groups dark light cycles bpa females exhibited higher average respiratory quotient control females indicative metabolizing carbohydrates rather fats various assessments voluntary physical activity home cage confirmed dark cycle bpa exposed females significantly less active setting control females similar effects observed bpa exposed males significant differences detected serum glucose insulin adiponectin leptin concentrations results suggest females developmentally exposed bpa exhibit decreased motivation engage voluntary physical activity altered metabolism carbohydrates fats could important health implications
context hyperandrogenic states obesity women associated insulin resistance androgens reduce glucose uptake adipose cells increase tnf alpha production peripheral monocytes inflammatory cytokines known detrimental effect insulin resistance aim present study explore role testosterone local cytokine production visceral adipose tissue women reproductive age design twenty four women years old undergoing elective abdominal surgery benign non inflammatory conditions recruited study women clinical hyperandrogenism diabetes hepatic renal dysfunction hypothyroidism bmi drugs known interfere hormonal levels fat metabolism excluded women classified two groups according bmi non obese bmi obese bmi basal blood sample drawn time surgery measurement glucose insulin total testosterone lipid profile circulating ccl total adiponectin omental fat tissue obtained women samples minced adipose tissue incubated vehicle ctl testosterone ccl tnfa androgen receptor mrna levels measured real time quantitative polymerase chain reaction qpcr normalized gapdh expression secretion ccl measured conditioned media elisa results expression ccl ctls significantly higher obese group compared non obese group fold ccl fold differences groups markers total group without stimulation ctl significant correlations tnfa expression bmi tgc levels total cholesterol expression ccl expression correlated bmi tgc levels stimulation produced increase ccl expression significantly larger obese group compared non obese group obese non obese moreover whole group positive correlation ccl expression treated tissues bmi cytokine determinations followed pattern mrna without significant differences conclusions testosterone increases ccl expression visceral adipose tissue obese women reproductive age response associated bmi results show new possible mechanisms connecting androgens insulin resistance chronic inflammation elsevier rights reserved
asia enthesitis related arthritis era frequent category juvenile idiopathic arthritis era strong association human leucocyte antigen hla subclinical gut inflammation hla transgenic rat model presence bacteroides bacteria gut appears cause spondyloarthropathy spa thus studied gut microbiota children era stool specimens patients era age matched healthy controls studied none gastrointestinal symptom received drug known affect gut motility microbiota preceding weeks specimen cdna library region bacterial rrna subjected high throughput massively parallel sequencing relationship specimens studied using principal ordinate analysis pcoa abundances various bacterial taxa alpha diversity compared groups eight patients repeat faecal specimen studied weeks probiotic therapy specimens yielded median range high quality reads pcoa gut microbiota era showed wider dispersion controls patients families bacteroidaceae enterobacteriaceae abundant prevotellaceae less abundant controls also genera bacteroides entercoccus klebsiella represented genus prevotella represented era patients probiotic therapy led non significant increase prevotellaceae patients era dysbiosis gut increased abundance bacteroides reduction prevotella probiotic supplementation subset patients reverse changes significantly
multiscale modeling means simulation powerful tool address many vital questions neuroscience example applied study process learning memory formation brain time simulation technique makes possible take advantage interoperability existing tools multi physics models well distributed computing however theoretical basis multiscale modeling sufficiently understood example need efficient accurate numerical methods time integration time constants model components different several orders magnitude individual dynamics mathematical definitions component together impose stability accuracy efficiency challenges time integrator following numerical investigations brocke frontiers computational neuroscience present new multirate algorithm allows handle component large system step size appropriate time scale take care error estimates recursive manner allowing individual components follow discretization time course keeping numerical error within acceptable bounds method developed ultimate goal minimizing communication components thus especially suitable simulations preliminary results support confidence multirate approach used class problems interested show dynamics ofa communication signal well appropriate choice discretization order system components may significant impact accuracy coupled simulation although ideas presented paper tested single model likely applied problems without loss generality believe work may significantly contribute establishment firm theoretical basis development efficient computational framework multiscale modeling simulations
paper addresses parallel machine scheduling problem step deteriorating jobs problem arises real environments processing job later specific time may require extra processing time time dependent variation known literature step deterioration several practical applications production planning computer programming medicine treatment equipment maintenance etc problem tackled work aim minimize total completion time identical parallel machines job deteriorating date observes step function processing time solving propose two novel mathematical models based set partitioning problem spp improve unique model proposed literature computational performance models implemented general purpose solver allows compete best algorithms proposed literature finally provide insights managing similar spp formulations large sized instances addressed elsevier rights reserved
paper presents new algorithm volume constrained expected compliance minimization continuum structures probabilistic loading directions using analytically determined exact objective gradient functions algorithm based upon finding particular set statistical parameters integration expected compliance function done symbolically automatically using symbolic manipulation software study mathematica used integrate simplify highly nonlinear expected compliance function demonstrated examples result symbolic pre processing step simple linear function defined particular subset inverse stiffness entries needed compliance computation coefficient set linear function forms base exact analytical gradient computation used optimal solution searching optimality criteria method define steepest descent direction naturally applied method replaced appropriate nonlinear solver matlab codes algorithm structures exact analytical sensitivities developed using topology optimization codes presented andreassen liu tovar structures starting points illustrative examples mathematica matlab codes presented demonstrate essence viability proposed approach highlight potential automatic symbolic computation structure optimization
paper provides ethnographical study ways infrastructure matters production knowledge social worlds rare diseases analyse role played relational database respect exists crossroads large complex network individuals institutions practices database forms part boundary infrastructure knowledge production constitutes one output infrastructural work needs articulated kinds activities matters concern analyse members network negotiate place forms knowledge production relation purposes highlight political nature distinction knowledge information frames collective action also show infrastructural inversion serves articulate knowledge production forms mobilisation thereby shaping reconfiguring boundary infrastructure whole
quality control laser additive manufactured medical implants interest especially nondestructive quality control performed parts implantation ray micro computed tomography microct used defect porosity analysis well comparing part surface computer aided design cad file cases limited use partly due variation scan types quality scans occur present simple method demonstrating use light metal casting reference porosity sample confirm good image quality quantify minimum detectable pore size selected scan settings makes good comparison additive manufactured parts since castings generally contain porosity full part cad comparison shows part compared cad file second quality control accuracy cad variance given minimum detectable pore size finally part sectioned scanned two higher resolution settings showing small porosity diameter present well distributed expected
second generation antipsychotics sga associated adverse cardiometabolic side effects contributing premature mortality patients mechanisms mediating cardiometabolic side effects remain poorly understood three independent studies recently demonstrated melatonin protective cardiometabolic risk sga treated patients one main target areas circulating melatonin brain suprachiasmatic nucleus scn hypothesized scn involved sga induced early cardiovascular effects wistar rats evaluated acute effects olanzapine melatonin biological clock paraventricular nucleus autonomic nervous system using immunohistochemistry invasive cardiovascular measurements western blot olanzapine induced fos immunoreactivity scn followed paraventricular nucleus dorsal motor nucleus vagus indicating potent induction parasympathetic tone involvement scn parasympathetic neuronal pathway olanzapine administration documented using cholera toxin retrograde tracing vasoactive intestinal peptide immunohistochemistry olanzapine induced decrease blood pressure heart rate confirmed melatonin abolished olanzapine induced scn fos immunoreactivity including parasympathetic pathway cardiovascular effects brain areas associated olanzapine beneficial effects including striatum ventral tegmental area nucleus accumbens remained activated scn olanzapine phosphorylated gsk beta regulator clock activity melatonin prevented bilateral lesions scn prevented effects olanzapine parasympathetic activity collectively results demonstrate scn key region mediating early effects olanzapine cardiovascular function show melatonin opposing potentially protective effects warranting additional investigation
hybrid solar energy conversion system described study designed exceed efficiency type technology alone combining advantages concentrated solar power csp technology high performance concentrated photovoltaic cpv cells hybrid system tilted different inclination angles track solar power different latitudes different time zones thermal management important cpv cells concentrated solar radiation onto cpv leads higher performance also generates waste heat flux work effects natural convection without interaction surface radiation system consisting cells optical funnels heatsink numerically investigated experimentally validated model influence inclination overall flow structure heat transfer examined effect funnels heat transfer enhanced heat transferred cells funnels time separation flow spaces funnels would take heat ambient minimum average temperature surrogate cells occurred inclination angle ltd inclination angle varied degrees degrees stagnation point moved downward surface heat sink towards edge heat sink degrees degrees stagnation point downward surface heat sink dramatic decrease average temperature surrogate cells inclination angles less degrees except separation region substrate side flow could flow freely adjacent funnels formed pair separation bubble spiral node top funnels inclination angles flow velocity found dominant factor influencing heat transfer flow pattern separation bubble top funnels however inclination angles degrees degrees stagnation point occurred edge heat sink surrogate temperature increased inclination angle reached flow trapped recirculated among funnels vortical wake top funnel disappeared concluded degrees degrees dominant factor influencing heat transfer funnel effect flow velocity stayed almost constant elsevier ltd rights reserved
authors describe case pseudocide patient appears feigned suicide case identified result routine reconciliation internally collected suicide data government collected mortality data authors discuss evolution concept pseudocide clinical literature consider issues related deceitful factitious behaviors suicide surveillance measurement
chronic hepatitis virus hcv infection characterized high interindividual variability response pegylated interferon ribavirin genetic polymorphism chromosome upstream interferon ifn associated twofold change sustained virologic response rate weeks treatment pegylated interferon ribavirin hcv genotype treatment naive patients conducted epigenetic analysis ifn promoter investigate whether dna methylation associated response hcv therapy dna samples hcv infected subjects receiving interferon free paritaprevir containing combination regimen hcv uninfected healthy controls analysed ifn methylation levels methylation strongly associated allele status whether adjusting hcv status hcv infected subjects genotypes significantly lower methylation levels relative genotypes allele resulting nine unit increase mean methylation level methylation levels correlate response subjects treated weeks however non subjects higher methylation levels likely relapse treatment duration weeks analysis suggests methylation status ifn promoter region may useful parameter identifies patients likely relapse following hcv therapy however continuing therapy sufficient duration overcome difference findings may provide mechanistic insight role ifn genetic variants hcv treatment response
report experimental verification emission properties photocathodes manipulated engineering surface electronic structure ultrathin multilayered mgo mgo films grown pulsed laser deposition tuning thickness flanking mgo layers monolayers observed increase quantum efficiency simultaneous decrease work function layer thickness scale trend direction measurements good excellent agreement theory angle resolved photoemission data multilayered sample showed emission profile metallic like momentum dispersion deviations theoretical predictions nemeth prl attributed imperfections real surfaces contrast ideal surfaces calculation photoemissive properties cathodes critical electron beam applications photoinjectors free electron lasers fel energy recovery linacs erl ideal photoemitter high quantum efficiency low work function low intrinsic emittance long lifetime demonstrated emission properties may systematically tailored control layer thickness ultrathin multilayered structures reproducibility emission parameters specific growth conditions excellent even though interfaces varying degrees roughness elsevier rights reserved
human action recognition well explored applications computer vision many successful action recognition methods shown action knowledge effectively learned motion videos still images action appropriate action knowledge learned different types media videos images may related however less effort made improve performance action recognition videos adapting action knowledge conveyed images videos existing video action recognition methods suffer problem lacking sufficient labeled training videos cases fitting would potential problem performance action recognition restrained paper propose adaptation method enhance action recognition videos adapting knowledge images adapted knowledge utilized learn correlated action semantics exploring common components labeled videos images meanwhile extend adaptation method semi supervised framework leverage labeled unlabeled videos thus fitting alleviated performance action recognition improved experiments public benchmark datasets realworld datasets show method outperforms several state art action recognition methods
fully mature vast number available virtualization solutions uptake creating opportunity remote virtual laboratories either supplement fully replace physical networking laboratories approach focuses nodes rather environments hosting nodes paper addresses setting virtual laboratories made widely available general purpose operating systems based linux act network operating system discuss several software defined networking solutions lay configuration setup virtual laboratories evaluate opportunity provide context learning potential experience conclude observation increasing number linux based network operating systems management network forwarding devices becomes management servers leads unification cloud fabric
plasma levels chemokine cxcl elevated mice following acute cocaine exposure decreased human cocaine abusers withdrawal cxcl also one chemokines located brain modulate dopamine transmission activation receptor cxcr assess role cxcl cxcr system behavioral effects cocaine tested hypothesis amd plerixafor cxcr antagonist would inhibit conditioned place preference cpp locomotor activation produced cocaine rats injected cocaine displayed cpp relative saline injected controls following conditioning sessions amd administered prior cocaine conditioning reduced development cocaine cpp amd also inhibited expression cocaine induced cpp paradigm injected following cocaine conditioning prior cpp testing addition amd pretreatment reduced locomotor activation produced acute cocaine injection affect basal locomotor activity relative saline injected controls repeated cocaine exposure produced significant increase fold cxcl mrna expression ventral tegmental area vta results suggest cxcl cxcr system brain reward circuit impacted cocaine exposure influences behavioral effects related abuse liability cocaine elsevier inc rights reserved
adaptive deep brain stimulation uses feedback state neural circuits control stimulation rather delivering fixed stimulation time currently performed patients parkinson disease elevations beta activity subthalamic nucleus demonstrated correlate clinical impairment provided basis feedback control trials adaptive deep brain stimulation pilot studies suggested adaptive deep brain stimulation may potentially effective efficient selective conventional deep brain stimulation implying mechanistic differences two approaches test hypothesis differences arise differential effects temporal dynamics beta activity latter constantly increased parkinson disease comes bursts different durations amplitudes demonstrate amplitude beta activity subthalamic nucleus increases proportion burst duration consistent progressively increasing synchronization effective adaptive deep brain stimulation truncated long beta bursts shifting distribution burst duration away long duration large amplitude towards short duration lower amplitude bursts critically bursts shorter duration negatively bursts longer duration positively correlated motor impairment stimulation conventional deep brain stimulation change distribution burst durations although adaptive conventional deep brain stimulation suppressed mean beta activity amplitude compared unstimulated state achieved selective effect burst duration adaptive deep brain stimulation whereas conventional deep brain stimulation globally suppressed beta activity posit relatively selective effect adaptive deep brain stimulation provides rationale approach could efficacious conventional continuous deep brain stimulation treatment parkinson disease helps inform adaptive deep brain stimulation might best delivered
article presents personal account socially inclusive education means academic university identify critical elements recognition right claim duty protect humanity value members society inclusion social justice belonging world unfettered disablements poverty illness prejudice dependent upon interdependence community collaborative enterprise call upon students education take stand work together end marginalisation exclusion poor abandoned disavow control privilege together free
sub pixel mapping spm process predicting spatially land cover classes within mixed pixels existing spm methods effect point spread function psf seldom considered paper generic spm method developed consider psf effect spm thereby increase prediction accuracy first demonstrate spectral unmixing predictions coarse land cover proportions used input spm convolution sub pixels within coarse pixel also sub pixels neighboring coarse pixels based finding new spm method based optimization developed recognizes optimal solution one convolved psf input coarse land cover proportion experimental results three separate datasets show spm accuracy increased considering psf effect elsevier inc rights reserved
introduction prostate cancer second leading cause cancer death men united states disease driven androgen receptor signaling majority patients initially respond androgen deprivation therapies lethal form disease occurs metastatic lesions progress setting low testosterone levels conventionally referred castration resistant prostate cancer crpc recent insights suggest crpc continues rely active pathway cell survival growth areas covered review summarizes rationale mechanism action relevant clinical data abiraterone acetate oral androgen biosynthesis inhibitor management crpc expert opinion abiraterone acetate oral well tolerated drug targets newly elucidated paradigm continued activation crpc abiraterone acetate approved crpc patients received docetaxel recent data suggest drug also effective utilized pre chemotherapy setting significant areas scientific investigation remain optimization understanding therapy
feature extraction one important steps computer vision tasks object recognition image retrieval image classification describes image set descriptors best one gives high quality description low computation study authors propose novel descriptor called histogram local global features using speeded robust feature surf descriptor hlg surf based combination local features obtained computation bag words surf global features issued novel operator called upper lower local binary pattern ullbp encodes texture analysis associated wavelet transform enhance effectiveness descriptor authors used colour information evaluate proposed method authors carried experiments different applications image retrieval image classification performance suggested descriptor evaluated calculating precision recall values using challenging corel coil datasets image retrieval image classification performance measured classification rate using challenging corel mit scene datasets experimental results showed proposed descriptor outperforms existing state art results
atrial fibrillation common arrhythmia patients aortic stenosis patients treated medically surgical aortic valve replacement associated increased risk adverse events including death growing evidence suggests significant impact outcomes also patients aortic valve stenosis undergoing transcatheter aortic valve implantation tavi conversely limited evidence available regarding optimal management condition review aims summarize prevalence pathophysiology prognosis treatment patients undergoing tavi
floating leaf blades waterlilies fulfill several functions wetland ecosystems production decomposition turnover well exchange processes production turnover rates floating leaf blades three waterlily species nuphar lutea nymphaea alba nymphaea candida presl studied three freshwater bodies differing trophic status alkalinity length percentages leaf loss marked leaf blades measured weekly growing season area biomass calculated based leaf length used calculate turnover rate floating leaf blades seasonal changes floating leaf production showed values decreased order nymphaea alba nuphar lutea nymphaea candida highest production reached nuphar lutea nymphaea alba alkaline eutrophic water bodies production per leaf relatively high species acid water body nymphaea candida showed short vegetation period low turnover rates ratio total potential leaf biomass maximum potential leaf biomass max three species ranged ratio vegetation period period floating leaves mean leaf life span ranged ratio growth period period appearance new floating leaves vegetation period clear differences nymphaea candida versus nuphar lutea nymphaea alba may due adaptations nymphaea candida euro siberic climate short lasting summer conditions
present model checking based method verifying list based concurrent set data structures concurrent data structures notorious hard get right thus verification received significant attention verification community data structures unbounded two dimensions list size unbounded unbounded number threads access thus model checking requires abstraction model bounded dimensions first show unbounded number threads model checked reduction finite model assuming bounded number list nodes particular leverage cmp compositional method abstracts unbounded threads keeping one thread concrete abstracting threads single environment thread next method proceeds series iterations iteration abstraction model checked spurious counterexample observed refined accomplished user inspecting returned counterexamples user determines returned counterexample spurious adds constraints abstraction form lemmas refine upon addition lemmas also verified correctness part cmp method thus since lemmas verified well show lemmas required refinement abstract model mined automatically using assertion mining tool daikon next show cmp method approach extended list dimension well fully verify data structures dimensions possible show correctness data structures unbounded number threads keeping one concrete thread abstracting others directly possible list dimension nodes pointed threads change list traversal method addresses challenge constructing abstraction concrete nodes nodes pointed threads change thread pointers move program execution method also allows refinement abstraction prove properties interest show soundness method establish utility model checking challenging concurrent list based data structure examples
article reviews sex children swch scale compares psychometric properties alternative measures field examination scale indicates one several instruments proportionally tap implicit theory schemas proposed literature help clinicians aim target pro offending schema since scale appears neglect certain types beliefs considered important investigation child molester cognition similar many instruments field swch scale unlikely identify offenders outwardly endorse child abuse items discriminant validity may better viewed capacity differentiate disagree less disagree scale possesses excellent reliability properties compared instruments however recently reported area curve calculations indicate scale predictive power sexual violent reconviction better chance would useful develop swch scale represent important types pro offending schema copyright john wiley sons ltd
microbial induced calcium carbonate precipitation micp cementation medium needs fully contact react bacteria inside soil sample pores sand goal study develop new sample preparation mold full contact flexible mold prepare samples micp process mold constructed using needle punched nonwoven geotextile material specimens different sizes prepared using full contact flexible mold evaluate engineering soil properties improved micp process results indicated mechanical improvement micp treated soil using full contact flexible mold one order magnitude higher typical sample preparation method full contact flexible mold enhances contact bacteria cementation medium promotes homogeneous calcium carbonate precipitation within sand pores
abnormal redox homeostasis oxidative stress proposed play role etiology several neuropsychiatric spectrum disorders emerging interest recently focused markers oxidative stress neuroinflammation schizophrenic spectrum disorders least particular subgroups patients altered expression genes related oxidative stress oxidative damage dna protein lipids well reduced glutathione levels central peripheral tissues could act synergistically contribute course disease herein discuss cellular mechanisms may operative neuroinflammation contributory schizophrenia address modulation endogenous cellular defense mechanisms potentially innovative approach therapeutics schizophrenia neuropsychiatric conditions associated neuroinflammation specifically discuss emerging role heme oxygenase prominent member neuroprotective network redox stress responsive mechanisms well importance glutathione relevant schizophrenia pathophysiology finally introduce hormetic dose response concept relevant important neuroprotection review hormetic mechanisms possible approaches manipulation neuroinflammatory targets may viable treating schizophrenia spectrum disorders wiley periodicals inc
opicapone novel potent reversible purely peripheral catechol methyltransferase inhibitor developed used adjunct levodopa aromatic amino acid decarboxylase inhibitor therapy parkinson disease thus study aimed compare plasma pharmacokinetics opicapone active metabolite bia administration single multiple oral doses rats wistar rats per group orally treated single multiple daily seven consecutive days oral doses opicapone blood samples collected post dosing cannula introduced tail vein rats quantifying opicapone bia plasma non compartmental pharmacokinetic analysis performed opicapone quickly absorbed time reach maximum plasma concentration dosage regimens extent systemic exposure opicapone increased approximately dose proportional manner single dosing within studied dose range opicapone bia showed relatively short plasma elimination half life small systemic accumulation multiple dosing hence pharmacokinetic concerns expected opicapone administered daily dosing regimen elsevier inc rights reserved
trust common factor network security cloud trust major factor trust develops relation user resource service provider develop strong trust strong trust path two entities model proposed builds strong trust path two important entities cloud namely user resources service provider trust path thus built strengthens security resources well authentication user implementation proved trust model developed efficient terms computation time
analysis data stored graph enables discovery certain information could hard see data stored using model relational however vast majority data information systems today stored relational databases dominate data management field last decades spite rise nosql technologies development new information systems still mostly based relational databases given increasing awareness benefits data analysis well current research interest graph mining techniques aim enable usage techniques relational data regard propose universal relational graph data conversion algorithm used preparation data perform graph mining analysis approach leverages property graph model mainly used graph databases maintaining level relational data clarity
lung diseases impose huge economic health burden worldwide key aspect several adult lung diseases idiopathic pulmonary fibrosis ipf chronic obstructive pulmonary disease copd including emphysema aberrant tissue repair leads accumulation damage impaired respiratory function currently effective treatments available diseases incidence rising planar cell polarity pcp pathway critical embryonic development many organs including kidney lung previously shown perturbation pcp pathway impairs tissue morphogenesis disrupts number shape epithelial tubes formed within organs embryogenesis however little known role pcp pathway beyond birth partly perinatal lethality many pcp mouse mutant lines investigate heterozygous looptail mice single copy core pcp gene vangl disrupted show mice viable display severe airspace enlargement impaired adult lung function underlying defects find vangllp lungs exhibit altered distribution actin microfilaments abnormal regulation actin modifying protein cofilin addition show vangllp lungs exhibit many hallmarks tissue damage including altered macrophage population abnormal elastin deposition elevated levels elastin modifying enzyme mmp observed emphysema vitro disruption vangl impairs directed cell migration reduces rate repair following scratch wounding human alveolar epithelial cells moreover using population data birth cohort young adults aged found evidence interactive effect vangl smoking lung function finally show pcp genes vangl scrib significantly downregulated lung tissue patients emphysema data reveal important novel role pcp pathway adult lung homeostasis repair shed new light genetic factors may modify destructive lung diseases emphysema
teach problem solving students develop problem solving skills process pass problem solving known well identifying steps students difficulty process provide data assist study aimed investigate students problem solving process related force motion unit scope hints need purpose hint supported problem solving instrument hspsi consists problems enables students reach hints need problem solving process developed participants study consist students receive education grade province trabzon students solved problems using hspsi five course hours one course hour per week data collected system records provided hspsi semi structured interviews conducted students field notes conclusions reached students difficulty steps understanding problem making solution plan hints need problem solving differ according students problems hints students need problem solving decrease regularly students helped certain degree solving problems suggestions made teachers provide students using problem solving strategies organizing researchers study condition using hspsi similar software students different levels
aims growing burden cardiovascular disease requires growth research innovation examine worldwide participation citation impact across cardiovascular research landscape investigate cross fertilization countries examine whether cross border collaboration affects impact methods results state art bibliometric methods indicators used identify cardiovascular publications web science map trends time output citation impact collaboration publication output cardiovascular research grown steadily increased participation worldwide china highest growth relative share usa share initially predominated yet reduced steadily time supra national region increased participation usa though average greater citation impact usa however number european countries well australia canada improved absolute relative citation impact usa europe hub cross fertilization strengthening collaborations strong citation links germany france remain central network usa highest number strong citation links countries countries especially smaller highly collaborative countries higher citation impact internationally collaborative research compared domestic publications conclusion participation cardiovascular research growing growth impact show wide variability countries cross border collaboration increasing particular within associated greater citation impact
paper reviews state art empirical hydrodynamic simple conceptual models determining flood inundation explores advantages limitations highlights recent advances discusses future directions addresses uncertainty analysed field various approaches identifies opportunities handling better aim inform scientists new field help emergency response agencies water resources managers insurance companies decision makers keep date latest developments guidance provided selecting suitable method model solving practical flood related problems taking account specific outputs required modelling purpose data available computational demands multi model multi discipline approaches recommended order advance research field elsevier ltd rights reserved
result rapid advances technology computer programming algorithms increasingly able generate expressive material light advances inevitable courts asked determine whether algorithmically generated content protected expression section canadian charter rights freedoms although algorithmically generated content serve many constitutionally protected purposes human expression paper explains supreme court canada current framework inadequate use context algorithmically generated content paper offers proactive principled solution consistent fundamental principles freedom expression articulated court keegstra solution allows content upholds keegstra principles protected despite fact algorithm creator may contemplated specific content
objectives describe health related quality life hrqol healthcare resource utilization women aged spain design descriptive analysis primary data spanish national health survey main outcome measures utility indices obtained eqdl questionnaire included survey utilization rates consultations hospitalizations emergency services medication intake hrqol utilization rates systematically compared women diagnosed women diagnosed chronic conditions occ healthy women age results utility indices women versus women diagnosed occ healthy women respectively year quality adjusted life years lost spain due population women aged resource utilization women significantly higher women conclusions larger impact hrqol healthcare consumption women aged occ appropriate treatment might entail important gain terms hrqol significant reduction healthcare consumption spain elsevier ireland ltd rights reserved
clustering unsupervised learning algorithm means algorithm one well known promising clustering algorithms converge local optimum iterative work hybridizing means algorithm genetic algorithms look solution global search space order converge global optima problem clustering number clusters increases number total records dataset leads scenario cluster contains single record thus cluster purity maximized maximum value however useless since common regularities among records seen therefore choosing best number clusters trivial instead choosing inappropriate number clusters risking main purpose clustering process genetic algorithm based means ensemble proposed order find consensus result several runs clustering task using different number clusters
introduction atrial fibrillation common cardiac arrhythmia development electroanatomical mapping increase demand advanced intracardiac imaging techniques left atrium pulmonary veins ivus demonstrate quantitative changes like lumen wall thickness well qualitative changes pulmonary wall ivus could also provide relevant real time imaging atrial pulmonary venous wall catheter ablation areas covered medline embase databases searched preclinical clinical studies ivus patients ablation atrial fibrillation left atrial arrhythmias article reviews years preclinical clinical experience ivus evaluating pulmonary veins expert commentary ivus proven valuable imaging technique management atrial fibrillation ablation understanding relation morphological changes functional results catheter ablation combined safety profile made appealing interventionists
backgroundmanagement chronic migraine new daily persistent headache ndph require aggressive outpatient inpatient treatment challenging ketamine suggested new treatment intractable population methodsthis retrospective review patients underwent administration intravenous subanesthetic ketamine ndph patients previously failed aggressive outpatient inpatient treatments records reviewed patients treated january december resultsthe mean headache pain rating using pain scale average admission discharge majority patients classified acute responders defined least point improvement headache pain discharge acute responders maintained benefit follow office visit sustained response achieve statistical significance mean length infusion days patients tolerated ketamine well number adverse events observed serious conclusionssubanesthetic ketamine infusions may beneficial individuals ndph failed aggressive treatments controlled trials may confirm studies may useful elucidating robust benefit less refractory patient population
analyze new results magnetically levitated body block including magnet whose bottom pole set way repel upper pole magnetic base excited non ideal energy source unbalanced electric motor limited power supply new results related jump phenomena increase power required sources near resonance manifestations non ideal system referred sommerfeld effect emulates energy sink work also discuss control strategies applied system resonance conditions order decrease vibration amplitude avoiding apparent energy sink
objectives synovitis acne pustulosis hyperostosis osteitis sapho syndrome rheumatoid arthritis ankylosing spondylitis seronegative spondyloarthropathy spa autoimmune diseases unknown etiology share clinical manifestations common previous family based investigations support genetic contributions susceptibility diseases current study evaluated whether three previously reported associated single nucleotide polymorphisms snps cdkal near kifb near lrrk muc genetic overlap across multiple autoimmune diseases including sapho syndrome spa materials methods genomic dna obtained sapho spa han chinese patients well healthy controls snps genotyped matrix assisted laser desorption ionization time flight mass spectrometry genotype allele frequencies analyzed using chi square test results cdkal significantly different sapho cases healthy controls odds ratios confidence intervals snps associated risk developing spa analysis genotype distributions showed similar results significant difference found genotype frequency sapho cases significant differences detected among patients spa conclusions results suggest cdkal associated risk developing sapho han chinese populations people carry risk allele might prone developing sapho syndrome
fast nearest neighbor search becoming crucial given advent large scale data many computer vision applications hashing approaches provide fast search mechanisms compact index structures address critical need image retrieval problems labeled training data available supervised hashing methods prevail unsupervised methods state art supervised hashing approaches employ batch learners unfortunately batch learning strategies may inefficient confronted large datasets moreover batch learners unclear adapt hash functions dataset continues grow new variations appear time handle issues propose osh online supervised hashing technique based error correcting output codes consider stochastic setting data arrives sequentially method learns adapts hashing functions discriminative manner method makes assumption number possible class labels accommodates new classes presented incoming data stream experiments three image retrieval benchmarks method yields state art retrieval performance measured mean average precision also orders magnitude faster competing batch methods supervised hashing also method significantly outperforms recently introduced online hashing solutions elsevier inc rights reserved
background nurses primary role promoting neonatal skin integrity skin care management critically ill neonate adhesive products essential secure needed medical devices significant factor contributing skin breakdown current literature offer definitive answer regarding products safely effectively work secure needed devices high risk neonatal population purpose determine adhesive method best practice safely effectively secure lines tubes high risk neonate population findings results main effect significant age group mean skin scores subjects younger group weeks higher skin scores older group weeks validating younger gestations higher risk breakdown use adhesives implications practice findings clearly identify product superior secure tubes lines least injurious skin high risk neonate neither transparent dressing transparent dressing hydrocolloid method clearly demonstrated advantage high risk preterm neonate anecdotal comments suggested staff preferred transparent dressing hydrocolloid method providing better adhesive protecting skin integrity findings validated younger gestations higher risk breakdown use adhesives therefore require close vigilance maintain skin integrity
background individuals knee osteoarthritis fatty infiltration thigh muscle associated poor physical performance strength however known whether also occurs calf impacts physical function aims investigated relationships volumes intramuscular fat intramf intermuscular fat imf subcutaneous fat scf lean muscle muscle adiposity thighs compared calves women knee methods mri scans thigh calf acquired women years knee discovery healthcare axial ideal iterative decomposition water fat echo asymmetry least squares estimation fat separated images segmented quantify intramf imf scf lean muscle volumes sliceomatic tomovision correlation linear regression analyses run results found positive relationship thigh calf intramf muscle adiposity scf volume controlling waist hip ratio relationships thigh calf imf lean muscle combined intramf imf volume significant discussion although correlation exists thigh calf muscle adiposity intramf scf hold true imf lean muscle greater amount intramf infiltration occurs thigh compared calf women knee conclusion calf thigh may involved pathologic changes muscle composition knee
water pollution large scale small scale plastic litter area growing concern macro plastic litter well known threat aquatic wildlife however effects micro sized nano sized plastic particles health organisms well understood small scale plastic particles easily ingested various aquatic organisms potentially interfere immune system therefore authors used freshwater fish species model organism nanoplastic exposure characterization polystyrene polycarbonate nanoplastic particles psnps pcnps respectively plasma performed effects psnps pcnps innate immune system fathead minnow investigated vitro effects psnps pcnps neutrophil function determined using battery neutrophil function assays exposure neutrophils psnps pcnps caused significant increases degranulation primary granules neutrophil extracellular trap release compared nontreated control whereas oxidative burst less affected present study outlines stress response cellular component fish innate immune system polystyrene polycarbonate nanoparticles aggregates indicates potential interfere disease resistance fish populations setac
resource leveling used project scheduling reduce fluctuation resource usage period project implementation fluctuating resource usage frequently creates untenable requirement regularly hiring firing temporary staff meet short term project needs construction project decision makers currently rely experience based methods manage fluctuations however methods lack consistency may result unnecessary waste resources costly schedule overruns research introduces novel discrete symbiotic organisms search optimizing multiple resources leveling multiple projects scheduling problem dsos mrlmp optimization model proposed based recently developed metaheuristic algorithm called symbiotic organisms search sos sos mimics symbiotic relationship strategies organisms use survive ecosystem experimental results statistical tests indicate proposed model obtains optimal results reliably efficiently optimization algorithms considered proposed optimization model promising alternative approach assisting project managers handling mrlmp effectively american society civil engineers
computing fractal dimension time consuming process nowadays data precision resolution many sensors increasingly high magnetic resonance ultrasounds microcomputed tomography etc furthermore applications require data post processing processing large data sets also common several analyses applications therefore fast algorithms computing required interactive applications graphics processing unit gpu programming become standard tool optimizing certain sorts time consuming algorithms problem fits gpu programming model well high speedups achieved cuda opencl two popular gpu technologies since require special knowledge computer graphics programming chapter present experience optimizing processing time classic box counting algorithm compute means cuda opencl gpu programming speedups cuda opencl single thread cpu version algorithm obtained cuda results better box counting algorithm strong dependency sorting opencl implementations best sorting algorithms efficient cuda ones
weartec nsf funded project focused activities related wearable technologies goals project develop intervention focuses solving real world problems practicing engineering design process immersed innovative area wearable technologies curriculum developed focused youth grades teach engineering design computer programming basic circuitry curriculum associated professional development designed encourage connections school school time instruction results pilot study suggest weartec activities promote female participation engineering technology activities addition student attitudes towards stem improved result participating program
visualizing large graphs edge bundling promising method yet subject several challenges speed clutter level detail parameter control present cubu framework addresses problems integrated way fully gpu based cubu bundles graphs million edges interactive framerates times faster comparable state art methods simple intuitive control bundling parameters cubu extends unifies existing bundling techniques offering ways control bundle shapes separate bundles edge direction shade bundles create level detail visualization shows graph core structure details demonstrate cubu several large graphs extracted real life application domains
research aimed investigate factors associated vitamin deficiency provide data prevalence patients suffering different psychiatric illnesses study cross sectional design included patients genders aged wide range mental disorders treated routine ambulatory hospital practice researchers collected data three sources medical records study questionnaire biochemical analysis patients serum samples concentration vitamin measured calcium phosphorus magnesium sodium potassium data analyzed using descriptive statistics methods hypothesis testing binary logistic regression level total patients deficiency vitamin among variables related demographics life style habits mental illness comorbid disorders drugs two female gender odds ratio confidence interval using clozapine significantly associated vitamin deficiency physical activity exercising offal diet significantly aggregated patients serum concentration deficiency cut level patients mental disorders high risk vitamin deficiency particularly females clozapine users well adequate physical activity dietary habits
propose interleaver based oil mach zehnder interferometer resonator incorporated one ann using method signal flow graph get simple closed form expressions transmission interleaver result indicates widths passband stopband interleaver improved remarkably much wider conventional mach zehnder interferometer interleaver proposed ideal rectangular spectral response finally analyzed influence exerted parameters transimission characteristics found transmission spectrum device depends highly oil intensity coupling coefficient coupler fiber loop length
paper robust control approach used address problem adaptive behavioral treatment design human behavior smoking exercise reactions treatment complex depend many unmeasurable external stimuli unknown thus crucial model human behavior many subject responses propose simple low order uncertain affine model subject uncertainties whose response covers probable behavioral responses proposed model contains two different types uncertainties uncertainty dynamics external perturbations patients face daily life uncertain model defined demonstrate least absolute shrinkage selection operator lasso used identification tool lasso algorithm provides way directly estimate model subject sparse perturbations estimated model robust control algorithm developed one relies special structure uncertainty develop efficient optimization algorithms paper concludes using proposed algorithm numerical experiment simulates treatment urge smoke
bariatric patients often suffer vitamin deficiency vdd morbid obesity vdd related non alcoholic fatty liver disease however limited data available regarding best strategies treating vdd particularly bariatric patients undergoing omega loop gastric bypass olgb therefore examined efficacy safety forced vitamin dosing regimen intervention effects liver fibrotic patients double blind randomized placebo controlled trial vitamin deficient patients undergoing olgb randomly assigned receive first month postoperatively oral vitamin doses intervention group placebo loading dose control group subsequent maintenance dose day groups month visit compared control group higher increase nmol lower prevalence secondary hyperparathyroidism observed intervention group serious adverse events related study medication found loading dose regimen effective increasing patients significant liver fibrosis case conventional supplementation placebo maintenance dose nmol findings indicate high vitamin loading dose first month postoperatively subsequent maintenance dose effective safe achieving higher vitamin concentrations olgb patients unexpectedly effective patients significant liver fibrosis potentially high clinical relevance requires investigation
meet clients owners multidimensional changing requirements construction management consultants cmcs ought possess diverse dynamic knowledge structure china although population cmcs grown point indispensable industry knowledge structure explored explicitly study presented paper investigated first conducting comprehensive content analysis curricula highest ranked construction management university courses china followed depth interviews experts resulting identification main knowledge areas grouped technology economy management law questionnaire survey conducted among experienced cmcs evaluate current level knowledge areas together importance need improvement main findings demonstrate significance identified knowledge areas also need substantial improvement practice research practical implications china cmcs develop necessary knowledge extent need improved provide better quality services future
today privacy key concept also one rapidly evolving technological advances consensus single definition fact concept privacy defined many different ways ranging right left alone commodity bought sold time powerful ambient intelligence ami systems developed deploy context aware personalised adaptive anticipatory services systems personal data vastly collected stored distributed making privacy preservation critical issue human centred focus ami systems prompted introduction new kinds technologies privacy enhancing technologies pet methodologies privacy design pbd whereby privacy concerns included design system one particular application field privacy preservation critical importance ambient assisted living aal emerging continuous increase ageing population aal focuses intelligent systems assistance better healthier safer life living environment paper first build previous work introduced new tripartite categorisation privacy right enabler commodity second highlight specific privacy issues raised aal third review discuss current approaches privacy preservation finally drawing lessons learned aal provide insights challenges opportunities lie ahead part methodology statistical analysis performed ieee publications database illustrate work aal scenarios elaborated cooperation city luxembourg
purpose childhood cancer stressful entire family preoccupation anxiety surrounding child illness may result parents children cancer overprotective less emotionally responsive toward children parenting response negative life event like childhood cancer may cause survivors insecurely attached healthy peers could downstream effects survivors romantic relationships later life therefore examined survivors perspectives parent behaviors adult attachment marital status among adult survivors childhood cancer relative controls methods one hundred forty nine young adult survivors matched controls age range indicated relationship status single partnered completed standardized questionnaires assessing memories upbringing warmth overprotection rejection adult attachment avoidance anxiety results adult survivors childhood cancer remembered mothers fathers emotionally warmer mothers less rejecting controls adult attachment overall similar survivors controls partnered survivors reported particularly low attachment related anxiety childhood cancer related higher mother father warmth associated lower attachment related avoidance turn greater likelihood relationship conclusion adult childhood cancer survivors remember parents overprotective reported positive parenting relative controls similar adult attachment relationship status results unexpected offer novel insights future prospective studies necessary better understand psychosocial late effects childhood cancer
leadership energy environmental design leed considered one successful green building rating systems one successful versions leed launched accredited projects globally paper reviews use leed investigates allocation pattern leed points critically analysing database leed certified projects certification sunset date results show innovation related points easiest obtain energy related material related points difficult obtain different regions either across world perform differently selected leed credits especially spatially specific credits brownfield redevelopment green power varied credit achievement patterns also identified yearly cross certification cross section levels study offers useful reference project developers understand leed rating systems regulatory bodies improve rating system elsevier ltd rights reserved
return oriented programming rop crucial attackers evade security mechanisms operating systems currently used malicious documents exploit viewer applications cause malware infection inspecting large number commonly handled documents high performance flexible detection methods required however current solutions either time consuming less precise paper propose novel method statically detecting rop chains malicious documents method generates hidden markov model hmm rop chains well one benign documents learning known malicious benign documents libraries used rop gadgets detection performed calculating likelihood ratio malicious benign hmms addition reduce number false positives rop chain integrity checking confirms whether rop gadgets link properly executed experimental results showed method detect rop based malicious documents false negatives false positives high throughput
framework developing product involving manufacturing processes developed integrated computational materials engineering approach key component framework process modeling tool includes thermal model microstructure model thermo mechanical property model using friction stir welding fsw process example development process modeling tool introduced detail thermal model microstructure model fsw steels validated experiment data model predict reasonable temperature hardness distributions observed experiment model applied predict residual stress joint strength pipe girth weld
many patients report symptoms come eating experience exclusion diets suggests certainly poorly absorbed rapidly fermentable carbohydrates may responsible monomeric short chain carbohydrate polymers exert osmotic forces trap water small bowel acceleration transit longer polymer polymers inulin pass small bowel unaltered fermented colon may cause distension symptoms recent developments magnetic resonance imaging confirm importance fructose stimulating small bowel water secretion negation presence glucose fructans impact small intestine cause colonic distension symptoms including bloating
environmental conservation management policy first emphasized water pollution control japan however kind passive conservation policy gradually shifted active approach satoumi includes restoration biodiversity biological productivity habitat well balanced nutrient cycle land sea many satoumi creation activities also characterized activities promote interactions land sea paper case study ago bay shima city mie prefecture japan introduced land sea interaction two sites improved promoting water exchange across dikes constructed land development land reclamation tidal flat restoration experiments conducted ago bay clearly showed promotion tidal exchange sea wetland area inner side dikes improved deteriorated sediment quality macro benthos conditions along results case study future tidal flat restoration japan also discussed elsevier ltd rights reserved
purpose inverting electroheat problems involves synthesizing electromagnetic arrangement coils geometries realize desired heat distribution end two finite element problems need solved first magnetic fields joule heat associated eddy currents generate based heat sources second problem heat distribution two part problem needs iterated obtain desired thermal distribution optimization time consuming process purpose paper parallelize process using graphics processing unit gpu real coded genetic algorithm speed accuracy design methodology approach coupled problem represents heavy computational load long wait times results gpu recently demonstrated enhance efficiency accuracy finite element computations cut solution times also used speedup naturally parallel genetic algorithm authors use gpu perform coupled electroheat finite element optimization genetic algorithm achieve computational efficiencies far better reported single finite element problem genetic algorithm coding objective functions real numbers rather binary arithmetic gives added speed accuracy findings feasibility method proposed reduce computational time increase accuracy established simple problem shaping current carrying conductor yield constant temperature along line authors obtained speedup cpu time gpu time ratio saturating population size increasing communications threads far better possible workstation research limitations implications using intrinsically parallel genetic algorithm gpu large complex coupled problems may solved quickly method demonstrated without accounting radiation convection may trivially extended completely modeled electroheat systems since primary purpose establish methodology feasibility thermal problem simplified neglecting convection radiation introduces error computational procedure still validated practical implications methodology established direct applications electrical machine design metallurgical mixing processes hyperthermia treatment oncology three practical application areas authors need compute exciting coil antenna arrangement current magnitude phase device geometry would accomplish desired heat distribution achieve mixing reduce machine heat burn cancerous tissue process presented accurately speedily social implications particularly mentioned application oncology alleviate human suffering use hyperthermia treatment planning cancer treatment method presented provides scope new commercial software development employment originality value previous finite element shape optimization coupled electroheat problems group used gradient methods whose difficulties explained others used analytical circuit models place finite elements paper applies massive parallelization possible gpus inherently parallel genetic algorithm extends single field system problems coupled problems thereby realizes practicable solution times computationally complex problem using gpu computations rather cpu accuracy enhanced using real number rather binary coding object functions accuracy speed gains realized
well wheel wtw methodology widely used policy support road transport seen simplified life cycle assessment lca focuses energy consumption emissions fuel consumed ignoring stages vehicle life cycle wtw results therefore different lca results order close gap authors propose hybrid wtw lca methodology useful assess greenhouse gas ghg profiles road vehicles proposed method hybrid wtw lca keeps main hypotheses wtw methodology integrates lca data restricted global warming potential gwp occurring manufacturing battery pack wtw data used ghg intensity electric mix consistency check main life cycle impact lci sources available literature numerical example provided comparing ghg emissions due use battery electric vehicle bev emissions internal combustion engine vehicle comparison done according wtw approach namely jec wtw version proposed hybrid wtw lca method ghg savings due use bevs calculated wtw range according hybrid method savings lower difference due gwp arises result manufacturing battery pack electric vehicles wtw methodology used policy support quantify energy content ghg emissions fuels powertrains produce results closer lca methodology adopting hybrid wtw lca approach evaluating ghg savings due use bevs important method considers gwp due manufacturing battery pack
newly proposed source inverter proven literature exhibit steady state voltage buck boost capabilities using unique impedance network coupled power source converter circuit paper presents transient modeling analysis voltage type source inverter aspects found challenging need carefully investigated attempting design advanced control algorithms controlling source inverter detailed analysis paper identifies several phenomena sides inverter would result inverter inferior non minimum phase transient response side phenomenon associated source impedance network shown small signal signal flow graph analyses right half plane zero control output transfer function also side phenomenon shown space vector analysis depend time intervals inverter states used reconstructing desired inverter output voltage based vectorial analysis method improving inverter transient response also presented lastly simulation results obtained using switching functional model experimental results obtained using laboratory prototype presented validating described theoretical concepts
paper describes general purpose parallel scheme efficiently focusing synthetic aperture radar sar data multicore based shared memory architectures rationale proposed tiling based parallel focusing model first discussed implementation structure illustrated adopted parallel solution based canonical processing pattern exploits segmented block based approach works successfully data acquired different spaceborne sar platforms insofar significant portion focusing algorithm amenable tiling approach decomposes problem simpler subproblems type also providing suitable mechanism explicitly control granularity computation proper specification tiling different stages algorithm relevant implementation makes use multithreading high performance libraries achievable performances experimentally investigated quantifying benefit parallelism incorporated prototype solution thus demonstrating validity approach accordingly canonical performance metrics evaluated pertinent scalability examined different multicore architectures furthermore order emphasize practical ability proposed parallel model implementation efficiently deal data different sar sensors performance analysis carried different realistic scenarios including data acquired envisat asar radarsat cosmo skymed platforms
comparative analysis electricity gas demand industrial sector long period time appears absent literature fact unlike electricity demand natural gas demand industrial sector well researched paper aims cover gap analyses electricity gas consumption patterns spanish manufacturing sector novel innovative quantitative approach based homogenous heterogeneous estimators used purpose results spurious estimations augmented mean group estimator show price elasticity gas demand significantly negative within range contrast price elasticity electricity demand statistically significant income elasticities show opposite pattern natural gas statistically significant whereas income elasticities electricity statistically significant within range compared previous findings preferred estimation shows variation regarding price elasticities natural gas demand elsevier ltd rights reserved
atopic dermatitis significant lifelong clinical impact affected individuals profound effects quality life patients families diagnosis usually reliably established basis history physical examination patients skin color blanching skin may helpful detect erythema lichenification follicular accentuation hypopigmentation common lighter skinned patients diagnosis established assessment severity persistence impact patient family life important guide treatment decisions published frontline medical communications
overvaluation shape weight binge eating disorder bed associated greater eating disorder psychopathology greater weight bias internalization arein turnassociated poorer mental physical health little known however significance cognitive processes rumination bed study examined rumination overvaluation shape weight eating disorder psychopathology weight bias internalization among treatment seeking patients bed comorbid obesity hierarchical multiple regressions indicated rumination associated eating disorder psychopathology weight bias internalization beyond influence overvaluation shape weight findings suggest among patients bed obesity rumination important cognitive process associated severity eating disorder psychopathology even accounting overvaluation shape weight patients greater rumination might likely dwell weight based discrimination experiences internalize negative attitudes additional controlled examination could determine whether rumination represents another potential target bed obesity treatment copyright john wiley sons ltd eating disorders association
potential benefits reinforcing active zone behind model sheet pile wall studied series plane strain laboratory model tests performed unreinforced reinforced active zones loaded rigid strip footing parameters including sand relative density reinforcement embedment depth type reinforcement footing location relative sheet pile wall length reinforcement number reinforcing layers varied sheet pile wall deflection loading measured finite element analyses performed prototype sheet pile wall supplement results model tests two dimensional plane strain model using computer code maxis used close agreement experimental numerical results observed results indicate inclusion reinforcement active zone leads reduction lateral deflection effectiveness reinforcement decreasing lateral deflection sheet pile wall attributed tensile strength type based results laboratory model numerical analyses critical values reinforcement parameters maximum reinforcing effects suggested results used development linear regression equations relating ultimate lateral capacity sheet pile wall aforementioned parameters
purpose among young men sex men ymsm aged years blacks african americans hispanics latinos disproportionately affected hiv accounting respectively diagnoses hiv infection united states district columbia ymsm color also disproportionately affected hiv national goals hiv infected persons retained hiv care analyzed surveillance data examine retention among ymsm living hiv infection methods characterized correlates retention hiv care clinical visits months apart within months diagnosis among ymsm inform strengthen local hiv care efforts analyzed data hiv surveillance system ymsm aged years diagnosed alive also combined demographic clinical variables sociodemographic data american community survey acs census tracts results ymsm diagnosed living hiv infection black latino ymsm census tract data available included analyses black latino white among linked care retained care multivariate analyses retention care less likely among year ymsm compared year old ymsm adjusted prevalence ratios apr confidence intervals conclusion retention hiv care suboptimal ymsm increased retention efforts warranted improve outcomes reduce age racial ethnic disparities
many states enacted laws improve school nutrition tested whether stronger state nutrition laws associated subsequently decreased obesity conducted retrospective national multi year panel data study analyzed children hospital philadelphia predictors laws regarding nutrition categories classification laws associated school students grades strength state laws none weak strong outcome weight status healthy weight overweight obese elementary middle high school national survey children health tested association strength laws weight using multinomial logistic regression evaluate main results conducted state level longitudinal analyses testing association competitive food beverage laws change obesity main analyses children ages years found strong state laws restricting sale competitive food beverages elementary school strong advertising laws across grades associated reduced odds obesity longitudinal analyses states strong competitive food beverage laws small significant decreases obesity compared states laws although research needed determine causal effect laws study suggests strong state laws limiting sale advertising unhealthy foods beverages schools associated decreased obesity rates elsevier inc rights reserved
prior taxometric research child molesters general sex offenders produced inconsistent contradictory results theoretical practical policy reasons however assume psychopathy taxon may exist sex offenders taxometric study might shed light issue mean minus cut mambac maximum covariance maxcov latent mode factor analysis mode taxometric procedures employed three overlapping samples sex offenders non relative child victims sex offenders non relative child adolescent victims child incest victims mixed sample sex offenders taxometric analyses revealed evidence continuous latent structure three samples results suggest psychopathy sex offenders child molesters particular organised quantitatively continuous rather qualitatively categorical
high performance phase locked loops plls critical power control grid connected systems paper presents new method designing pll single phase systems based derivative elements des quadrature signal generator qsg constructed two des parameters pll realized using based qsg avoids errors due overlap accumulation present plls based integral elements pll based second order generalized integrator additionally frequency feedback needed allows proposed pll achieve high performance grid frequency changes rapidly paper presents model pll theoretical performance analysis respect frequency domain time domain behavior error arising discretization process also compensated ensuring pll method suitable implementation digital control system simulation experimental results show proposed pll achieves good performance harmonic rejection dynamic response
consider linear state dynamic game played event tree determine analytically price anarchy poa given ratio player outcome cooperative game outcome noncooperative game next illustrate findings context pollution control problem conduct sensitivity analysis assess impact poa lower upper bounds varying different parameter values elsevier rights reserved
inflammatory bowel diseases associated various hepatobiliary disorders reported crohn disease ulcerative colitis may occur moment natural course disease prevalence liver dysfunction rises accordingly definitions used different studies fatty liver considered common hepatobiliary complication inflammatory bowel diseases primary sclerosing cholangitis specific one less frequently inflammatory bowel diseases associated hepatobiliary disorders include autoimmune hepatitis primary sclerosing cholangitis overlap syndrome igg associated cholangiopathy primary biliary cholangitis hepatic amyloidosis granulomatous hepatitis cholelithiasis portal vein thrombosis liver abscess spectrum manifestations varies according type inflammatory bowel diseases treatments inflammatory bowel diseases may cause liver toxicity although incidence serious complications remains low however early diagnosis drug induced liver injury major importance affects future clinical management facing abnormal liver tests clinicians undertake full diagnostic work order determine whether hepatic abnormalities related inflammatory bowel diseases management hepatic manifestations inflammatory bowel diseases usually involves hepatologists gastroenterologists complexity situations
tuberculosis caused mycobacterium tuberculosis mtb infection mtb one oldest human pathogens evolves mechanisms implied human evolution lungs first organ exposed aerosol transmitted mtb gaseous exchange therefore guards immune system lungs macrophages dendritic cells dcs important defense mtb infection several studies discussing functions dcs mtb infection genome wide pathways networks still incomplete furthermore immune response induced dcs varies therefore analyzed cross talk genome wide genetic epigenetic interspecies networks gwgeins mtb dcs mtb determine varying mechanisms host pathogen relates dcs early mtb infection first performed database mining construct candidate cross talk gwgein human cells mtb constructed dynamic models characterize molecular mechanisms including intraspecies gene microrna mirna regulation networks grns intraspecies protein protein interaction networks ppins interspecies ppin cross talk gwgein applied system identification method system order detection scheme dynamic models identify real cross talk gwgeins using microarray data dcs mtb identifying real cross talk gwgeins principal network projection pnp method employed construct host pathogen core networks hpcns mtb dcs mtb infection process thus investigated underlying cross talk mechanisms host pathogen determine pathogen counteracts host defense mechanisms phi dos mtb hrv early infection based findings propose rvc potential drug target important defensive role furthermore membrane essential proteins cytoplasm mtb could also potential drug targets important roles mtb survival cell types also propose drugs lopinavir tmc atsm gtsm potential therapeutic treatments mtb infection since target potential drug targets
study provides first attempt combine uio bimoo preparation composite via electrostatic interaction induced self assembly process synthesized products characterized ray diffraction xrd scanning electron microscopy sem fourier transform infrared spectroscope ray photoelectron spectroscopy xps brunauer emmett teller bet surface area analyse vis diffuse reflectance spectroscopy vis drs photocatalytic activities obtained bimoo uio composites assessed degradation rhodamine visible light irradiation comparing pristine materials developed bimoo uio composite molar ratio labelled bmuo showed best photocatalytic activity supposed participation bimoo increased use solar energy existence uio restrained recombination rate photo generated electron hole pairs moreover bimoo uio composite showed excellent stability recyclability cycling experiment mechanism plausible pathway degradation also discussed paper elsevier inc rights reserved
research explores interactions among mexican immigrants mexican born allies immigrant support center isc southwest propose support mexican immigrants resettling allies work isc must apply cultural knowledge competent communication mexican speakers structure strategic actions sprain boromisza habashi taking ethnography communication eoc approach investigate means meanings communication hymes speakers point cultural knowledge competent communication data study include months observation interviews community staff members public documents collected fieldwork findings reveal five means communication meaningful speakers isc research demonstrates practical utility eoc understanding cultural expectations communication may assist limit isc efforts support resettlement
previous works indicated geniposide could regulate glucose stimulated insulin secretion gsis improved chronic high glucose induced dysfunctions pancreatic cells molecular mechanisms remain largely unknown present study investigated role amp activated protein kinase ampk high glucose induced cell injury explored associated molecular mechanisms rat ins pancreatic cells data suggested geniposide obviously prevented cell damage induced high glucose ins cells increased protein levels cell apoptosis associated enzymes including heme oxygenase bcl apparently attenuated protein level bax apoptotic protein addition compound ampk inhibitor remarkably inhibited effects geniposide protein levels bcl bax aicar ampk activator potentiated role geniposide protein levels bcl bax importantly geniposide directly prevented cleavage caspase induced high glucose effect also evidently prohibited pre incubation compound high glucose treated ins cells furthermore using method rna interfere proved treatment ampk sirna attenuated effects geniposide apoptosis associated proteins cell viability data suggest ampk plays crucial role geniposide antagonizing high glucose induced pancreatic cells injury
children play characterized pleasurable also viewed critical child health well yet past decade play researchers advocates various disciplines suggested decreasing opportunities children play particularly school one concern changing play environment schools reducing children active play options thereby contributing increases childhood obesity building findings quebec adipose lifestyle investigation youth quality commentary suggests opportunities engage physical activity may indeed differentially shaped school play environments physical health may factor stake unequal play environments schools altogether new concern argue nevertheless important highlight within physical activity research settings children overall well including experience pleasure creativity imagination sociability also shaped school play environment addressing possible inequalities children experience play schools propose several questions future research directions addressing children health well school environment
background many countries eastern mediterranean region emr undergoing marked demographic socioeconomic transitions increasing cancer burden region sought examine national cancer incidence mortality profiles support regional cancer control planning emr methods globocan data used estimate cancer incidence mortality country cancer type sex age emr countries calculated age standardized incidence mortality rates per using direct method standardization results cancer incidence mortality rates vary considerably countries emr incidence rates highest lebanon per males females respectively mortality rates highest lebanon egypt among males somalia among females profile common cancers differs substantially sex females breast cancer common cancer countries followed cervical cancer ranks high lower income countries region males lung prostate colorectal cancer combination represent almost cancer burden countries attained high levels human development conclusions common cancers largely amenable preventive strategies primary secondary prevention hence need effective interventions tackling lifestyle risk factors infections high mortality observed breast cervical cancer highlights need break stigmas improve awareness surrounding cancers published elsevier ltd
bedside teaching encounters btes involve doctor patient student interactions providing opportunities students learn patients differing concerns patient care student education balanced situ remains largely unknown undefined video ethnographic study explores patient involvement largely student centric activity feedback sequences students learn clinical practical skills drawing data subset multi site study used conversation analysis investigate verbal non verbal interactional practices examine patients inclusion exclusion teaching activities across btes general practice general surgery medicine participants analysis identified two representations patient patient embodied patients actively involved patient body used primarily prop learning overall patients excluded physical examination talk based activities exclusion occurred physical positioning doctor patient student doctors students talking rather patients using medical jargon online commentaries patients exclusion visibly noticeable eye gaze patients middle distance gaze coincided medical terminology complex wording inclusory activities maintained patient embodied teaching activities doctors skilful embedding teaching within care including vocalising clinical reasoning processes students providing patients warrant listen allocating turns talk eye contact study uniquely demonstrates visible nature patient exclusion providing firm evidence affects patient empowerment engagement within educational activities tomorrow doctors
online photo sharing increasingly popular activity internet users users constantly sharing images various social media social networking sites online communities blogs content sharing sites article present extensive study exploring privacy sharing needs users uploaded images develop learning models estimate adequate privacy settings newly uploaded images based carefully selected image specific features study investigates visual textual features images privacy classification consider basic image specific features commonly used image processing well sophisticated abstract visual features additionally include visual representation sentiment evoked images knowledge sentiment never used context image classification privacy purposes identify smallest set features combined together others perform well properly predicting degree sensitivity users images consider case binary privacy settings public private well case complex privacy options characterized multiple sharing options results show carefully selected features one may achieve high accuracy especially high quality tags available
hypergraph partitioning commonly used solving large scale integration vlsi placement problem data mining sparse matrix multiplication parallel computing paper presents novel heuristic hypergraph partitioning based nonlinear programming approach consider adjacent one dimensional bins since reduction cuts equivalent reducing net length across two bins vertices moved across bins way density vertices bin balanced per partitioning requirement reduction wirelength walshaw partitioning benchmarks tool naps results consistently comparable obtained chaco tool nap produces better cuts chaco instances graph samples
considering importance mother support adaptation sexually abused child relevant determine mothers children involved intergenerational cycle child sexual victimization differ dyads child abused purpose study compare mother child dyads sexually abused children according whether mother victim child sexual abuse sample included dyads sexually abused children aged years old mothers reporting maternal child abuse followed social welfare services province quebec canada two groups mothers compared past family abuse experiences past family relations mental health history current psychological distress parenting behaviors current levels family functioning children compared adaptation multivariate analyses indicated mothers reporting child sexual abuse likely report maltreatments childhood greater prevalence lifetime history alcohol abuse disorders dysthymia panic disorder compared mothers experienced csa compared children whose mothers experienced csa whose mothers experienced csa showed higher rates problems behaviors likely report sexually abused trusted person results highlight specific clinical needs assessment treatment sexually abused children whose mothers experienced child sexual abuse
paper presents concrete software architecture dedicated ambient intelligence ami features requirements proposed behavioral model called higher order agent hoa captures evolution mental representation agent one plan simultaneously plan expressions written composed using formal algebraic language namely aglotos plans built automatically fly system concurrent processes based specific semantics guidance service also proposed assist agent execution moreover due specific structure aglotos expressions update sub plans realized automatically accordingly revising intentions hence maintaining consistency agent
general purpose data parallel computing graphical processing unit gpu much structured today nvidia cuda parallel programming frameworks exploiting cuda programming framework present work proposes novel methodology formulated around gpu hardware architecture memory hierarchy accelerate calibration process classification model named enn primarily developed avalanche forecasting enn based brute force nearest neighbours approach employs snow meteorological variables search past days similar conditions events associated past similar days analysed generate forecast model required calibrated regularly ensure higher degree forecast accuracy terms heidke skill score hss calibration enn carried artificial bee colony abc algorithm swarm intelligence driven population based metaheuristic algorithm requires thousands hss evaluations complete calibration process matlab sequential code calibration runs minutes proposed methodology delivered acceleration calibration process methodology combines primitives parallel implementations brute force algorithm population based metaheuristic algorithms scalable deal similar real world problems major objective paper highlight methodology associated future research areas elsevier inc rights reserved
background data indicates denmark relatively high risks occupational injuries evaluated injuries resulting hospitalization occupation methods gainfully employed men younger divided industrial groups followed using national inpatient registry hospitalized injuries following icd injuries grouped six categories head upper extremities back trunk lower extremities ruptures sprains strains standardized industrial hospitalization ratios shrs calculated pearson independence test performed category results industrial differences ascertained injury category highest associated injury category upper extremity injuries ranging shr fire services salvage corps shr slaughterhouse industry carpentry joinery bricklaying construction work significantly high shrs injury categories whereas administrative work significantly low throughout conclusions occupational surveillance systems based hospitalized injuries used identify high risk industries thereby suggest direct prevention efforts ind med wiley liss inc
parts globe solar energy available throughout year areas terrain mostly flat justifiable use solar power automotive industry previous publication explored concept solar battery car single double solar array trailers solar array trailers maximize acquired solar energy thereby minimizing use battery power resulting excess power derived solar trailers used drive car accessories necessary parts world building previously published results paper aims determine applicable limits car trailer concept variations reference configuration considered corresponding battery power needed calculated upper limits drag area coefficient ground inclination rolling resistance established furthermore effective rolling resistance factor trailer determined since manufacturing imperfections component flexibilities misalignments trailers limit applicability car trailer system use trailers justifiable effective rolling resistance factor less one ideal environment application solar battery cars global scale may drive across australian continent along stuart highway highway drive used world solar challenge assess performance various categories solar cars similar track used publication assess response solar battery cars solar trailers cumulative well daily energies required drive reported car car trailers furthermore response clear cloudy conditions throughout year discussed results compared energies required typical race car paper concludes summary results elsevier ltd rights reserved
multi mode mobile equipments requires efficient radio frequency filtering solutions solve interference problems umts system integrated mobile television function designed fabricated pair filters consisting band pass band stop filter based temperature stable bulk acoustic wave resonator baw technology filters measurably demonstrate low insertion loss similar high rejections similar fast roll similar mhz pass band stop band furthermore achieve low temperature coefficient frequency tcf ppm five times lower conventional baw filter low tcf critical importance particularly sharp skirt region since trivial frequency changes associated temperature variation could lead failure filter specifications skirt corners proposed filtering solution applied minimize interference present similar systems mobile phones integrated satellite radio gps navigation
elliptic curves finite field invariant supersingular ordinary whose embedding degree low studied ordinary case give conditions characterizing elliptic curves fixed embedding degree respect subgroup prime order conditions give parameterizations terms two integers show several examples families infinitely many curves similar parameterizations need fixed kth root unity underlying field moreover elliptic curve admits distortion maps example provided
cloud computing become buzzword area high performance distributed computing provides demand access shared resources internet self service dynamically scalable metered manner reap full benefits much research required across broad array topics one important research issues need focused efficient performance scheduling goal scheduling map job resources optimize one objectives scheduling cloud computing belongs category problems known hard problem due large solution space thus takes long time find optimal solution cloud environment best find suboptimal solution short period time metaheuristic based techniques proved achieve near optimal solutions within reasonable time problems paper provide extensive survey optimization algorithms cloud environments based three popular metaheuristic techniques ant colony optimization aco particle swarm optimization pso genetic algorithm novel technique league championship algorithm lca
symbolically generated network functions analog integrated circuit complicated general reason variety simplification methods proposed literature work novel topology based symbolic simplification method proposed capable generating simplified symbolic network function together simplified small signal circuit technique developed applying recently proposed graph pair decision diagram gpdd algorithm generates symbolic network function stored binary decision diagram bdd two types element elimination directly operated gpdd data structure performance variation eliminating symbol original circuit assessed means two monitored response metrics gain phase margin sorting performance loss circuit elements less performance loss eliminated resulting reduced gpdd automatically simplified network function simplified small signal circuit available simultaneously reduction applications two operational amplifier examples confirm effectiveness proposed methodology
field treatment wetlands tws rapidly expanding arguably tasked studying understanding one complex water treatment systems available microbial communities generally considered responsible majority wastewater constituent degradation tws however also known spatially heterogeneous temporally dynamic well structurally functionally diverse presented meta analysis peer reviewed journal articles utilized microbial community assessment methodology period july total papers reviewed included microbial community assessment aspect subsequently classified representing past research july classified representing current microbial community research general microbial community research increased time marked surge past four years microbial community structure currently commonly used methodological type followed activity enumeration function respectively areas research focus included nitrogen transformations organic degradation emerging contaminants general characterization studies also accounting significant proportion microbial communities range systems investigated last four years meso scale commonly studied system size followed large scale micro scale pilot scale free water surface flow horizontal subsurface flow vertical flow systems studied approximately equal proportions majority studies focused gaining fixed media biofilm samples analysis rather rhizosphere interstitial water looking efforts regional perspective shows asia publishing majority research main focus systems structural community assessment european north american studies generally evenly distributed among structure function activity enumeration majority studies completed systems south america africa oceania published fewer studies focused structural community assessment selection investigations great strides made field microbial community assessment tws functional assessment methods developed better utilized related directly water treatment use high powered metagenomics sequencing illumina hiseq instrumentation rise development utilization functional assays dna microarrays community level physiological profiling allowing complete community assessment used concert activity enumeration newly implemented stable isotope methodologies field tws certainly moving away black box understanding past
introduction atopic dermatitis related atopic diseases asthma allergic rhinitis known asthma allergic rhinitis impaired immune responses may predispose infections study sought determine whether adult associated systemic infections whether association strengthened plus another atopic disease methods cross sectional study obtained information adults national health interview survey nhis primary exposure history without additional atopic disease asthma allergic rhinitis self reported systemic infections primary outcomes survey logistic regression performed adjusted odds ratios aor reported results nhis associated increased risk sinusitis aor cis head chest cold gastrointestinal illness nhis pneumonia influenza strep throat tonsillitis sinusitis head chest cold infectious disease increase atopic disease mirrored increase number infectious outcomes statistically significant combined dataset conclusion associations plus another atopic disease systemic infections suggest underlying immune defect may contributing microbial susceptibility studies warranted understand burden infectious disease population
apply developed local polar edge detection method lped method binary image pixel either black white obtain boundary points objects embedded randomly distributed noise background sub milli second time apply newly developed grouping clustering algorithm separate boundary points objects individual object boundary point groups apply fast identification tracking technique automatically identify object unique geometry shape track movement simultaneously objects like two objects paper concentrate algorithm design superfast grouping technique like classical combinatorial clustering algorithm computation time increases exponentially number points clustered linear time grouping method grouping time increases linearly number total points grouped total time automatic grouping boundary points separated object boundary groups milli seconds live computer experiments demonstrated presentation
analysis travel mode choice important task transportation planning policy making order understand predict travel demands advances machine learning led numerous powerful classifiers usefulness modeling travel mode choice remains largely unexplored using extensive dutch travel diary data years enriched variables built natural environment well weather conditions study compares predictive performance seven selected machine learning classifiers travel mode choice analysis makes recommendations model selection addition addresses importance different variables relate different travel modes results show random forest performs significantly better investigated classifiers including commonly used multinomial logit model trip distance found important variable importance variables varies classifiers travel modes importance meteorological variables highest support vector machine temperature particularly important predicting bicycle public transport trips results suggest analysis variable importance respect different classifiers travel modes essential better understanding effective modeling people travel behavior elsevier ltd rights reserved
boiling water reactors bwrs inherently nonlinear physical system physical system reactivity feedback caused moderator density temperature allows several effects reflecting nonlinear behavior system stability analyses bwr done simplified reduced order model couples point reactor kinetics thermal hydraulics reactor core linear stability analysis bwr steady states shows critical value bifurcation parameter feedback gain hopf bifurcation occurs stable unstable domains parametric spaces predicted linear stability analysis stability system include stability steady states stability dynamics system limit cycles must included study stability nonlinear stability analysis bifurcation analysis becomes indispensable component stability analysis scenario hopf bifurcation occur one free parameter studied formulates birth limit cycles excitation limit cycles makes system bistable case subcritical bifurcation whereas stable limit cycles continues unstable region supercritical bifurcation distinction subcritical supercritical hopf done two parameter analysis codimension bifurcation scenario generalized hopf bifurcation takes place separates sub supercritical hopf bifurcation various types bifurcation limit point bifurcation limit cycle lpc period doubling bifurcation limit cycles neimark sacker bifurcation limit cycles identified floquet multipliers lpc manifests region bistability whereas chaotic region exist cascading region bistability chaotic solutions drawn various parametric bifurcation diagrams elsevier rights reserved
background adiponectin apn key player energy homeostasis strictly associated cerebrovascular neurodegenerative diseases since apn also belongs anti inflammatory acting adipokines may influence neuroinflammation neurodegenerative processes decided study apn levels amyotrophic lateral sclerosis als neurodegenerative diseases methods assessed apn levels elisa immunoassay serum cerebrospinal fluid cohort familial sporadic als patients characterized normal body mass index absence dysautonomic symptoms screening serum apn levels also performed patients affected neurological disorders including fronto temporal dementia ftd patients means compared using non parametric wilcoxon test pearson spearman rho used assess correlations variables results whole als group serum apn levels different compared age sexmatched control group ctr gender specific analysis enlightened significant opposite apn trend als males characterized lower values als ctr als females showing higher amounts als ctr sex linked difference significantly enhanced familial als cases apn levels als cerebrospinal fluids unrelated serum values linked sex familiarity disease finally screening serum apn levels patients affected neurological disorders revealed highest serum values ftd patients conclusions opposite serum apn levels gender related als altered several neurological disorders highest values ftd shares als several overlapping neuropathological features investigations needed clarify possible involvement apn neuroinflammation neurodegeneration
chen zadrozny developed linear extended yule walker xyw method determining parameters vector autoregressive var model available covariances mixed frequency observations variables model parameters determined uniquely available population covariances var model identified present paper extends original xyw method extended xyw method determining arma parameters vector autoregressive moving average varma model available covariances single mixed frequency observations variables model paper proves conditions stationarity regularity miniphaseness controllability observability diagonalizability parameters model parameters determined uniquely available population covariances single mixed frequency observations variables model varma model identified single mixed frequency covariances published elsevier
objective determine differences patient populations choose subdermal implants versus intrauterine devices iuds contraceptive purposes study design retrospective chart review electronic medical records women presented university texas medical branch galveston regional maternal child health program clinics southeast texas march march received subdermal implant iud reviewed differences characteristics women chose either form contraception determined results total charts reviewed women chose subdermal implant chose iud patients chose subdermal implants likely long acting reversible contraceptive larc method previously previous vaginal deliveries year larc choice race specific compared caucasian women african american women significantly likely choose iud hispanic women significantly likely choose subdermal implants conclusion different populations choose subdermal implants versus iuds contraception research needed determine etiologies differences
present case feminizing adrenal tumor high estradiol presented fatigue anorexia decreased libido gynecomastia bilateral gynaecomastia without galactorrhea estradiol high low testosterone abdominal ultrasound showed huge tumor right kidney compressed confirmed ctscan surgery well limited much vascularized mass weighing removed successfully rawal med
nowadays population growth environmental constraints climate change adversely affect water supply systems ability keep demand due lack unsuitable distribution dispersion water resources precipitation soil resources etc inter basin transfers water could solution order balancing supply demand water different areas study optimal designing water conveyance basin basin investigated water transferred two dams tunnel structure since water flow tunnel pressure increasing dam height cause decrease tunnel diameter constant water conveyance efficiency purpose study transferring water flow two basins supplying agriculture consumption environmental needs therefore mathematical program developed first solve governing equations water balance reservoir hydraulic tunnel various strategies including different diameters tunnel dam height considered finally best strategy economic technical viewpoint proposed results showed dam height tunnel diameter economic options convey water
large variety molecular pathways melanoma progression suggests individual molecular alteration crucial aim define molecular alterations underlying metastasis formation gene expression profiling performed using microarray qrt pcr define alterations matched primary metastatic melanoma cell lines data integrated publicly available unmatched tissue data invasiveness cell lines determined matrigel invasion assays invasive clones primary melanoma derived cell lines also selected two metastatic cell line models created regional lymph node wma wma inv wmb distant lung wmb wmb inv metastatic models majority metastasis genes downregulated enriched adhesion itga pathways upregulation immune pathways characteristic distant metastases whereas increased rap signaling specific regional sub cutaneous metastases qrt pcr analysis selected integrins highlighted possible importance itga metastatic process distinguishing regional distant metastases identified functionally relevant gene clusters influenced metastasis formation data provide evidence integrin expression patterns may important distant metastasis formation copyright wolters kluwer health inc rights reserved
phenotyping important understand plant biology current solutions costly versatile difficult deploy solve problem present phenotiki affordable system plant phenotyping relying shelf parts provides easy install maintain platform offering box experience well established phenotyping need imaging rosette shaped plants accompanying software available source code processes data originating device seamlessly automatically software relies machine learning devise robust algorithms includes automated leaf count obtained images without need depth affordable device sic deployed growth chambers greenhouse acquire optical images approximately adult arabidopsis rosettes concurrently data device processed remotely workstation via cloud application based cyverse paper present proof concept validation experiment top view images arabidopsis plants combination genotypes compared previously phenotypic analysis respect morphology growth color leaf count performed comprehensively confirm findings others extracted traits showing phenotype reduced cost also perform extensive validations external measurements higher fidelity equipment find loss statistical accuracy use affordable setting propose device set instructions analysis software publicly available http phenotiki com significance statement phenotyping important understand plant biology image based methods costly versatile difficult deploy present affordable easy deploy phenotyping platform publicly available software quantify rosette growth morphology color leaf count
present method estimate multivariate gaussian distribution diffusion tensor features set brain regions based small sample healthy individuals use distribution identify imaging abnormalities subjects mild traumatic brain injury multivariate model receives apriori knowledge form neighborhood graph imposed precision matrix models brain region interactions additional sparsity constraint model estimated using graphical lasso algorithm mahalanobis distance healthy tbi subjects distribution mean used evaluate discriminatory power model experiments show addition apriori neighborhood graph results significant improvements classification performance compared model take account brain region interactions one uses fully connected prior graph addition describe method using model detect regions contribute overall abnormality dti profile subject brain elsevier rights reserved
switching reactive components high voltage circuit breaker generate transients electrical network decrease power quality produce excessive stresses power apparatus conventional solutions provide degree mitigation effective reliable solution successfully deployed validated controlled switching furthermore extend useful life existing prevent costly replacement solution retrofitted cbs last years hydro quebec network technology evolved considerably last ten years initially used shunt reactors shunt capacitor banks proven technology often applied energization unloaded power transformers well matter application type retrofitting proven effective cbs variety manufacturers technologies long experience many lessons learned innovative ideas developed regarding optimal target specifications switching strategies commissioning procedures valorization data recorded switching events using acquisition functionalities intrinsic controlled switching device csd possible beyond theoretical principles optimize simulation models analysis field measurements ongoing process data collection offers possibility expanding knowledge field improving diagnostics related equipment also allows industrial partners apply developments new applications flexible transmission systems facts power line energization fast switching wind farm connection distribution network
tolerances play important role modem manufacturing engineering impact significantly quality product machining cost conventional methods tolerances design divided two separate sequential stages product tolerance design process tolerance design sequential tolerances design method would result problems cooperation continuity consistency two separate design stages rational approach tolerance design concurrent tolerancing consolidate two sequential design stages one paper genetic algorithm used concurrent tolerance design based manufacturing cost quality loss practical example used illustrate design process calculation results using compared conventional nonlinear optimization method
research aimed predict maximum varying blank holder force vbhf punch stroke order eliminate cracks cup deep drawing product constant blank holder force process frequently capable prevent cracking effectively using slab method assuming constant volume material simple analytical approach maximum vbhf conducted failure deformation cracking criteria every stage punch stroke cracking criteria based maximum strength materials steel sheet spcd grade thickness used study diameter cylindrical cup shaped product analytic calculation maximum vbhf compared fem simulations effects prevention cracking analytical results maximum vbhf much different fem simulation compared application constant blank holder force vbhf quite effective preventing occurrence cracking increasing formability deep drawing authors published elsevier
background information individual risk death following dialysis therapy initiation may inform decision initiate maintenance dialysis older adults derived validated clinical risk prediction tool cause mortality among older adults first months maintenance dialysis treatment study design prediction model using retrospective administrative clinical data setting participants linked administrative clinical data define cohort older adults age years alberta canada initiated maintenance dialysis therapy excluding acute kidney injury may march candidate predictors demographics laboratory data comorbid conditions measures health system use outcomes cause mortality within months dialysis therapy initiation analytical approach predicted mortality logistic regression fold cross validation results older adults died within months developed point risk score month mortality included age years older points glomerular filtration rate min point min points atrial fibrillation points lymphoma points congestive heart failure points hospitalization prior months points metastatic cancer points model discrimination statistic calibration hosmer lemeshow chi reasonable examples score equated predicted half individuals would die first months limitations tool externally validated thus generalizability assessed conclusions used readily available clinical information derive internally validate variable tool predict early mortality among older adults dialysis therapy initiation following successful external validation tool may useful clinical decision tool aid decision making older adults kidney failure national kidney foundation inc
based ieee standard frame aggregation considered one major factors improve system performance wireless local area networks wlans medium access control mac perspective order fulfill requirements high throughput performance feasible design automatic repeat request arq mechanisms becomes important providing reliable data transmission paper two mac defined arq schemes proposed consider effect frame aggregation enhancement network throughput aggregated selective repeat arq asr arq algorithm proposed incorporates conventional selective repeat arq scheme consideration frame aggregation hand aggregated hybrid arq arq protocol proposed enhance throughput performance adopting reed solomon block code forward error correction fec scheme novel analytical models based signal flow graph established order realize retransmission behaviors schemes simulations conducted validate compare proposed arq mechanisms existing schemes based service time distribution numerical results show proposed arq protocol outperforms retransmission schemes owing effective utilization fec mechanism
model description crystal nucleation proposed incorporating classical nucleation theory concepts spatial heterogeneity glass forming liquids assumed nucleation processes may proceed detectable rates liquid like soft regions suppressed solid like rigid parts determining appropriately fraction liquid like solid like regions dependence temperature approach allows one achieve satisfactory agreement classical nucleation theory experiment relatively high temperatures also temperatures lower nucleation rate maximum model tested successfully several silicate glasses revealing homogeneous volume nucleation phenomena interplay crystallization glass transition also discussed giving independent verification validity basic assumption elsevier rights reserved
obese subjects achieve weight loss show increased functional connectivity dorsolateral prefrontal cortex dlpfc ventromedial prefrontal cortex vmpfc key areas executive control reward processing investigated potential real time functional magnetic resonance imaging fmri neurofeedback training achieve healthier food choices enhancing self control interplay brain areas trained eight male individuals overweight obesity age years bmi regulate functional connectivity dlpfc vmpfc means four day fmri neurofeedback protocol including day three training runs comprised six regulation six passive viewing trials regulation runs four training days participants successfully learned increase functional connectivity dlpfc vmpfc addition trend towards less high calorie food choices emerged training however associated trend towards increased covertly assessed snack intake findings proof concept study indicate overweight obese participants increase functional connectivity brain areas orchestrate top control appetite high calorie foods neurofeedback training might therefore useful tool achieving maintaining weight loss elsevier ltd rights reserved
class real complicated systems including chemical reactions biological systems information processing laser systems electrical circuits information exchange brain activities modelling secure communication related ones presented nonlinear non identical hyper chaotic systems main goal present investigation synchronize two non identical hyper chaotic master slave systems given models complicated systems based realization efficient automated adaptive sliding mode control scheme research presented mentioned systems need dealt proposed control scheme since two non identical systems completely synchronized one case whole chosen states master slave systems coincided time steps long effect external disturbance uncertainty unknown parameters could truly ignored due fact investigated hyper chaotic systems taken consideration representation number complicated processes mentioned external disturbance uncertainty unknown parameters traditional control approaches actually realized satisfactory manners purpose proposed control scheme designed cope synchronization error reasonable amount time order drive applicable hyper chaotic systems consequently performance proposed control scheme considered verified numerical simulations
objective investigate effects mesterolone prostate patients treated aging male syndrome methods cross sectional study conducted june september endocrinology metabolism department yuzuncu yil university van turkey comprised patients symptoms aging male syndrome low testosterone given mesterolone day per oral two months aging male symptoms international prostate symptom score questionaires prostate related quality life scores completed prostate ultrasonography usg performed treatment total testosterone free testosterone gonadotropins estradiol prolactin sex hormone binding globulin well total free prostate specific antigen also studied results patients study prostate volume increased decreased change however statistically significant mesterolone significantly improved aging male symptoms international prostate symptom prostate related quality life scores improvements though significant independent changes prostate volume total testosterone sex hormone binding globulin andestradiol decreased free testosterone showed change fraction free testosterone increased total free prostate specific antigen change conclusion mesterolone proved safe alternative treatment aging male syndrome also improved lower urinary tract symptoms prostate related quality life
paper study extent electric propulsion disrupting order automotive industry six extensions christensen notion disruptive innovation decades automotive sector relied internal combustion engine ice established propulsion technology due environmental regulation geo political scarcity problems associated fossil fuel use electric propulsion increasingly applied sole additional power source elaborate christensen typology rooted industrial analysis regime evolution framework based changes technology institutional context production use special attention consumer perspectives government regulation offer hypothesis structural conditions market disruption test hypothesis development trajectory full electric vehicles fev drawing evidence range recent fev studies analysis suggests disruptive niche full electric mobility currently insufficient displace ice regime elsevier inc rights reserved
point inclusion problem important secure multi party computation involves two parties one private point private area want determine whether point inside area without revealing respective private information previously proposed point inclusion protocols suitable specific area circle rectangle convex polygon paper present novel privacy preserving point inclusion quantum protocol arbitrary area surrounded plane geometric figure compared classical related protocols protocol advantages higher security lower communication complexity
background childhood trauma increases risk range mental disorders including psychosis whereas mechanisms unclear previous evidence implicated atypical processing emotions among core cognitive models particular suggesting altered attentional allocation towards negative stimuli increased negativity bias tested association childhood trauma brain activation emotional face processing patients diagnosed psychosis continuum disorders particular tested childhood trauma associated differentiation brain responses negative positive face stimuli also tested trauma associated emotional ratings negative positive faces method included patients diagnostic statistical manual mental disorders dsm schizophrenia spectrum bipolar spectrum diagnosis history childhood trauma obtained using childhood trauma questionnaire brain activation measured functional magnetic resonance imaging presentation faces negative positive emotional expressions scanner session patients performed emotional ratings faces results higher levels total childhood trauma associated stronger differentiation brain responses negative compared positive faces clusters comprising right angular gyrus supramarginal gyrus middle temporal gyrus lateral occipital cortex cohen patients schizophrenia childhood trauma associated reporting negative faces negative positive faces less positive cohen conclusions along observed negativity bias assessment emotional valence faces data suggest stronger differentiation brain responses negative positive faces higher levels trauma
background health magazines effectively deliver health information data regarding student led magazines promote health exist objective evaluate whether children health knowledge interests lifestyle choices improve following distribution studentled health magazine methods elementary students worked teachers paediatric residents publish health magazine healthy lifestyle challenge page promoted reduction soda pop consumption pre poststudent questionnaires explored knowledge interests behaviours related health results sex grade distributions similar pre postquestionnaires ninety seven percent children reported magazine helped learn health pre postknowledge scores differ following distribution percentage students reported drinking soda increased reported drinking glasses soda per day increased conclusions student led health magazine effective motivating short term student reported behavioural change
convolutional neural network cnn well known machine learning algorithm widely used field computer vision amazing performance image classification rapid growth applications based cnn various acceleration schemes proposed fpga gpu asic implementation specific hardware accelerations challenging part implementation convolution obtain efficient design convolution cnn paper proposes novel technique singular value decomposition approximation svda reduce usage resources experimental results show proposed svda hardware implementation achieve reduction resources range loss classification accuracy less
epidemiological data linked birth control formulations increased risk infant acute leukemia involving mll rearrangements reverse transcription polymerase chain reaction pcr studies showed estradiol enhanced mll transcription addition common translocation partners mllt mllt concentration estradiol triggered mll mllt localization without affecting interaction genes located chromosomes estradiol also stimulated generation mll mllt fusion transcripts seen pcr rnai knockdown activation induced cytidine deaminase aicda suppressed induction mll mllt fusion transcript formation observed estradiol additionally chromatin immunoprecipitation chip analysis showed estradiol dependent localization aicda mll intron upstream hotspot dna cleavage rearrangement downstream within intron combined studies show levels estradiol consistent observed pregnancy potential initiate mll fusions aicda mediated mechanism
purpose research understand relationship positive negative affect perceived health mediated psychosocial resources whether culture collectivistic individualistic role relationship structural equation models applied first expressed direct indirect relationship health second reflected indirect influence health resources mediated models tested two cultures one individualistic spain collectivistic mexico results showed models work differently cultures spain significant differences two models mexico direct indirect relationship model functioned better results interesting implications influence health could different depending culture therefore future research reconsider cultural variable would interesting way influence perceived health different influence directly indirectly psychosocial resources influence directly would fascinating future research would replicate including countries using biological measurements health
compulsive buying disorder cbd borderline personality disorder bpd highly comorbid accordingly theories concerning etiological factors cbd bpd overlap present study aimed testa multivariate etiological model cbd presence bpd sample comprised shopping mall customers female mean age cbd measured using edwards compulsive buying scale revised version bpd measured using mclean screening instrument bpd impulsivity global self esteem contingent self esteem psychiatric distress also assessed overall participants scored cut value cbd bpd measures respectively total bdp cbd cbd also bpd corresponding risk ratio path analysis revealed contingent self esteem beta impulsivity beta exerted strongest mediating effects followed psychiatric distress beta global self esteem beta controlling effect bpd distress higher predictive value men contingent self esteem higher predictive value women data suggest impulsivity contingent self esteem distress lesser extent account high comorbidity bpd cbd etiological risk factors differ men women elsevier ltd rights reserved
paper proposes synthesis different mathematical models power electronic converters based thevenin norton equivalent circuits models composed impedances harmonic noise sources helpful predict conducted electromagnetic interferences emi generated converters connected electrical network moreover extracted impedances contribute improve emi filters since considered filter load upstream downstream filter sides analytical model tested pspice simulations validated experimental measurements frequency mhz
report development surface enhanced raman scattering sers based lateral flow immunoassay lfia sensor highly sensitive detection thyroid stimulating hormone tsh clinical fluids raman reporter labeled gold nanoparticles aunps used sers nano tags using sersbased lfia test strip presence tsh could identified color change test line addition quantitative evaluation tsh possible monitoring characteristic raman peak intensity sers nano tags limit detection lod estimated approximately two orders magnitude sensitive achieved conventional colorimetric lfia sensor based naked eye consequently possible diagnose hyperthyroidism well hypothyroidism since tsh concentration lower detected using sersbased lfia detection technique therefore approach strong potential feasibility application early diagnosis tsh hormone related diseases elsevier rights reserved
advent nanotechnology medical arena led unique ways biomaterials engineering device modifications disease detection treatment end two principal nanomedicine focus areas cancer cardiovascular pathologies current chapter aimed presenting comprehensive review nanotechnology based strategies cardiovascular diseases emphasis targeted delivery therapeutic payloads selectively disease site rationale strategies stem need resolving issues rapid drug clearance plasma induced drug deactivation suboptimal drug availability disease site indiscriminate biodistribution drugs leading harmful systemic side effects arise drugs administered directly systemic circulation significant application nanotechnology resolving issues packaging drugs within plasma stable nanovehicles preferentially accumulate vascular disease site via passive uptake bind actively site via antigen specific ligands decorated vehicle surface past three decades significant advancements understanding vascular disease associated genomics proteomics cellular molecular mechanisms well nanoscale microscale strategies biomaterials engineering led several exciting nanomedicine approaches vascular disease treatment chapter describe approaches terms materials engineering payload release mechanisms biochemical biophysical design parameters delivery platforms integration multiple design parameters functionalities single vehicle platform along discussing promises limitations vascular nanomedicine approaches
high performance parallel applications irregular data accesses becoming critical workload class modern systems particular execution workloads emerging many core systems expected significant component applications data mining machine learning scientific computing graph analytics however power energy constraints limit capabilities individual cores memory hierarchy chip interconnect systems thus leading architectural software trade offs must understood context intended application behavior irregular applications notoriously hard optimize given data dependent access patterns lack structured locality complex data structures code patterns ported two irregular applications graph community detection using louvain method grappolo high performance conjugate gradient hpccg tilera many core system conducted detailed study platform independent platform specific optimizations improve performance well reduce overall energy consumption conduct study employ auto tuning based approach explores optimization design space along three dimensions memory layout schemes gcc compiler flag choices openmp loop scheduling options leverage mit opentuner auto tuning framework explore recommend energy optimal choices different combinations parameters conduct depth architectural characterization understand memory behavior selected workloads finally perform correlation study demonstrate interplay hardware behavior application characteristics using auto tuning demonstrate whole node energy savings performance improvements relative baseline instantiation relative manually optimized variants elsevier inc rights reserved
hypertension associated development white matter hyperintensities wmh brain risk factors mild cognitive impairment hormonal shifts menopause alter vascular function putting women risk hypertension wmh elevations aortic hemodynamics precede appearance clinically defined hypertension relationship aortic hemodynamics development wmh women known therefore study aimed characterize aortic hemodynamics relationship wmh postmenopausal women aortic systolic diastolic blood pressure aortic augmentation index alx aortic round trip travel time aortic tonometry examined postmenopausal women age years wmh calculated fluid attenuated inversion recovery mri using semi automated segmentation algorithm wmh fraction total white matter volume positively associated aortic systolic regression coefficient adjusting age addition wmh fraction positively associated aix inversely associated aortic adjusting age results suggest assessing aortic hemodynamics may identify individuals risk accelerated development wmh guide early treatment reduce wmh burden cognitive impairment future
laser frequency stabilisation telecommunications band realised using pound drever hall pdh error signal transmission spectrum fabry perot cavity used opposed traditionally used reflected spectrum comparison done using analogue well digitally implemented system study forms part initial step towards developing portable optical time frequency standard frequency discriminator used experimental setup fibre based fabry perot etalon phase sensitive system made use optical heterodyne technique detect changes phase system lock amplifier used filter mix input signals generate error signal error signal may used generate control signal via pid controller error signal realised wavelength correlates optical frequency thz implementation analogue pdh technique yielded error signal bandwidth ghz digital implementation yielded bandwidth ghz
improving water footprint wfp crops implementation water harvesting techniques wht help save water enhance crop production study investigated impact different whts green blue total wfp components sorghum production western sudan water harvesting used tool reducing water consumption minimizing wfp two consecutive rainy seasons average wfp sorghum estimated ton green component providing highest contribution according wfp analysis significant differences wht treatments tide ridging providing greatest reduction compared treatments including ridging basin respectively similar trend found regarding soil moisture fresh dry matter productivity yield blue water component important impact total wfp sorghum production
examined association body mass index bmi body weight perception weight control behaviors problematic internet use nationwide sample korean adolescents cross sectional data korean youth risk behavior web based survey collected boys girls middle high schools grades analyzed participants classified groups based bmi underweight normal weight overweight obese body weight perception underweight normal weight overweight weight control behavior weight control behavior appropriate weight control behavior inappropriate weight control behavior risk problematic internet use assessed korean internet addiction proneness scale youth short form boys girls inappropriate weighty control behavior likely problematic internet use underweight overweight obese boys girls likely problematic internet use boys girls subjective perception underweight overweight positively associated problematic internet use given negative effect inappropriate weight control behavior special attention needs given adolescents inappropriate weight control behavior educational intervention adolescents control weight healthy ways needed
traditional anticoagulants used intermittent hemodialysis unfractionated heparin ufh increasingly low molecular weight heparins lmwhs repeated prolonged exposure ufh lmwhs may disturb hemostasis uremic patients vascular adhesion protein vap secreted vascular smooth muscle cells adipocytes endothelial cells functional monoamine oxidase activity elevated atherosclerosis diabetes mellitus obesity aim study assess effects ufh lmwhs vap concentration patients effects single session vap also evaluated well vap levels regard type renal replacement therapy studied hemodialyzed patients mean age years dialysis vintage months patients treated means hemodiafiltration hdf mean age years vintage months hdf months patients anticoagulated enoxaparin dalteparin nadroparin ufh sessions vap assessed using kits biovendor modrice czech republic patients hdf significantly lower vap compared patients found vap concentration patients dialyzed using lmwh ufh similar effect session vap concentration diabetic patients higher serum vap non diabetic hdf associated lower vap levels indicating less pronounced endothelial cell injury hemodialysis type heparin seems effect vap levels hemodialyzed patients however cross sectional prospective design limitation study
purpose work twofold first aims analyze teaching learning processes applied degrees enable regulated professional activities technical industrial engineering industrial engineering precisely examines competences related manufacturing engineering either bachelor master level second intends establish simple easy process evaluate competences acquired certain bachelor master degree result possible identify current weaknesses study plans could universities starting point definition procedures areas improvement allow better match among study plans acquisition competences learning results finally achieved authors published elsevier ltd
across two studies test prediction multicultural experiences reduce intercultural prejudice increasing openness experience study frequency self reported multicultural experiences associated greater openness less ethnic prejudice openness explained relationship multicultural experiences ethnic prejudice study experimentally manipulated multicultural experience compared control condition participants exposed cultural members elements foreign cultures reported higher openness experience expressed less prejudice toward cultural groups also evidence multicultural exposure openness caused secondary transfer effects prejudice reduction findings suggest exposure multicultural environments improve intercultural attitudes personality shifts openness experience
study examined association cognitive vulnerability factors seasonality students classified based seasonal pattern assessment questionnaire experiencing moderate mild seasonality nondepressed low seasonality controls completed explicit dysfunctional attitudes automatic negative thoughts seasonal attitudes rumination implicit implicit associations test measures cognitive vulnerability one winter one nonwinter assessment relative low mild seasonality participants moderate seasonality participants endorsed automatic thoughts rumination winter dysfunctional attitudes across seasons moderate mild seasonality participants endorsed maladaptive seasonal attitudes low seasonality participants groups demonstrated increased dysfunctional attitudes automatic thoughts rumination stronger implicit associations light dark winter findings support possible cognitive mechanism winter depression onset maintenance unique individuals moderate opposed mild seasonality
background african american youth urban centers often reside poorly resourced communities face structural disadvantage result higher rates poor behavioral health factors mental health problems juvenile justice system involvement substance use risky sex lower school engagement parental monitoring shown protective regards risk factors less understood effects parental warmth conjunction monitoring objective study examined whether parental monitoring warmth main mediated relationship behavioral health factors among low income african american youth method african american youth completed self administered questionnaires parenting factors monitoring warmth mental health juvenile justice system involvement substance use school engagement sexual risk behaviors results participants reported higher mean parental monitoring versus warmth parental monitoring correlated lower substance use delinquency unsafe sex higher school engagement higher parental warmth contrast uniquely correlated better youth mental health also higher rates alcohol cigarette marijuana use conclusions monitoring youth high levels appears common effective strategy parents poorly resourced communities associated lower behavioral health risks contrast parental warmth positive negative associations behavioral health suggesting research needed clarify circumstances within parental warmth may protective
purpose much like sexism ageism multifaceted prejudice involves benevolent hostile attitudes toward older adults many scales designed measure hostile ageism yet none dedicated measuring benevolent ageism current studies developed validated item measure ambivalent ageism scale aas design methods employed four stages scale development validation stage created benevolent ageist items adapted existing ageism measures stages refined pool items additional testing factor analysis retained nine items loading strongly two factors related benevolent ageism cognitive assistance physical protection unwanted help order enable researchers contrast benevolent hostile attitudes added four hostile ageist items stage assessed test retest reliability item scale results aas good test retest reliability good internal consistency alpha predicted benevolent hostile ageism subscales differentially predicted attitudes toward older adults higher scores hostile subscale predicted lower competence warmth ratings whereas higher scores benevolent subscale predicted higher warmth perceptions implications aas useful tool researchers assess hostile benevolent ageism measure serves important first step designing interventions reduce harmful effects hostile benevolent ageism
background eye movement desensitization reprocessing emdr evidence based treatment ptsd however unclear whether emdr shows effectiveness patients substance use disorders sud comorbid ptsd trial examine effectiveness emdr reducing ptsd symptoms patients sud ptsd methods design conduct single blinded rct among patients sud comorbid ptsd admitted german addiction rehabilitation center specialized treatment patients sud comorbid ptsd patients randomized receive either emdr added sud rehabilitation non trauma focused ptsd treatment tau tau alone primary outcome change baseline ptsd symptom severity measured clinicianadministered ptsd scale month follow secondary outcomes change baseline substance use addiction related problems depressive symptoms dissociative symptoms emotion dysregulation quality life assessments carried blinded raters admission end treatment month follow expect emdr plus tau effective reducing ptsd symptoms tau alone mixed models conducted using intention treat per protocol approach discussion study aims expand knowledge effectiveness emdr patients sud comorbid ptsd expected finding superiority emdr reducing ptsd symptoms compared non trauma focused ptsd treatment may enhance use trauma focused treatment approaches patients sud morbid ptsd
autism spectrum disorders asd highly heterogeneous developmental conditions characterized deficits social interaction verbal nonverbal communication obsessive stereotyped patterns behavior repetitive movements social interaction impairments characteristic deficits asd also evidence impoverished language empathy profound inability use standard nonverbal behaviors eye contact affective expression regulate social interactions others difficulties showing empathy failure share enjoyment interests achievements others lack social emotional reciprocity developed countries reported children asd cdc reports approximately one children suffer asd despite intense research focus asd last decade underlying etiology remains unknown genetic research involving twins family studies strongly supports significant contribution environmental factors addition genetic factors asd etiology comprehensive literature search implicated several environmental factors associated development asd include pesticides phthalates polychlorinated biphenyls solvents air pollutants fragrances glyphosate heavy metals especially aluminum used vaccines adjuvant importantly majority toxicants common ingredients cosmetics herbicides almost regularly exposed form fragrances face makeup cologne air fresheners food flavors detergents insecticides herbicides review describe various scientific data show role environmental factors asd elsevier ltd rights reserved
present work introduces curvelet like directional filter discusses application edge detection general images fracture detection gpr data filter essentially curvelet adjustable anisotropy orientation tuned given target wavenumber retaining properties curvelets bound scaling rules curvelet frame individually steerable local trait data hence dubbed curveletiform curveletiforms used single multi directional modes manner simple computationally inexpensive demonstrably efficient gpr data generally contains straight curved edge like objects comprising reflections planar interfaces notoriously susceptible broadband noise fractures important class interfaces determine health state rocks man made structures primary targets gpr surveys geotechnical engineering environmental applications demonstrated examples curveletiforms efficiently recover information specific scale geometry straight curved edges general images gpr data may distinguish reflections small large fractures discriminate groups fractures resolve fracture density aid assessment damage rocks structures elsevier rights reserved
authors considered bulk viscous fluid gravity within framework kaluza klein space time bulk viscous coefficient expressed positive constants take gamma gamma equation state perfect fluid exact solutions corresponding field equations given assuming particular model form lambda lambda constant studied cosmological model two stages first stage studied model viscosity second stage studied model involve viscosity cosmological model involve viscosity studied five possible scenarios bulk viscous fluid coefficient total bulk viscous coefficient seems negative bulk viscous coefficient proportional hence second law thermodynamics valid however valid generalised second law thermodynamics total bulk viscous coefficient seems positive bulk viscous coefficient proportional second law thermodynamics generalised second law thermodynamics satisfied throughout evolution calculate statefinder parameters model observed different cdm model finally physical geometrical properties models discussed
canine obesity number one health concern dogs worldwide regular physical activity improve health owners advised exercise dogs regular basis however limited information exists associations overweight status dogs walking activity online survey conducted june august coinciding broadcast national television programme exploring dog behaviour information gathered included signalment overweight status owner reported information duration frequency dog walking university liverpool ethics committee approved project owners consented data use simple multiple logistic regression analyses used determine associations overweight status dog walking activity data available adult dogs reported overweight owners dogs reported overweight dogs likely neutered older various breeds represented including beagle cavalier king charles spaniel golden retriever labrador retriever pug frequency duration walking negatively associated overweight status multiple regression analysis duration frequency independently negatively associated odds overweight along range factors including age neuter status breed study identified associations overweight status exercise future studies determine reason association whether changes walking activity influence weight status
aim article present findings analytical framework designed monitor discriminatory political discourse immigration understanding relevant studies three disciplines political science social psychology linguistics framed racism try infer racism may manifest discourse particular discriminatory tendencies combination tendencies contributed designing proposed analytical framework aims means standards systematically certify political discourse discriminatory quantify much discriminatory discourse assess discrimination legitimised justified implementing framework within context catalonia pilot study offers global picture catalan political discourse immigration constructed standards appears appear discourse viability framework proven conclude could basis comparative research contexts
direct drive actuators permanent magnet linear synchronous motors pmlsms widely used high velocity high precision applications detent force however deteriorate performance even excite mechanical resonance paper focuses novel detent force compensation scheme pmlsm systems combination structural design control method first due bandwidth constraint control system eliminating high frequency ripples unfeasible skewed permanent magnets pms considering optimal skewing length designed suppress high order harmonic components second based model pmlsm skewed pms linearization observer derived applied independently velocity controller diminishing low order harmonic components facilitate implementation digital control system discretization method taking account estimated errors designed online calculation estimated detent force injected control system feedforward way tune proposed scheme properly convergence algorithm analyzed utilizing lyapunov stability theory simulation studies performed prove effectiveness proposed method experiments provided confirm theoretical analysis simulation results
method grinding adding rubber pad led sapphire substrate ceramic supporting proposed though ansys finite element analysis obtains high flatness surface substrate efficiently experimental results also confirmed grinding inch sapphire substrate cushion total thickness error ttv microns bow microns therefore upholstered film one efficient economic highly automated ways grind sapphire substrate
osteoporosis characterized increasing osseous fragility fracture resulting low mass deteriorated microarchitecture bone tissue hormone replacement therapy alendronate frequently used treat osteoporosis primary therapeutic strategy adverse effects severely limited extensive clinical application therefore urgent develop alternative complementary therapeutic agents anti osteoporosis interestingly people focusing complementary alternative medicine traditional chinese herbs formulas gradually recognized safe effective agents treatment osteoporosis particular notable trend increasing studies making efforts clarify anti osteoporotic effects mechanism tonifying kidney yin herbs formulas category agents identified effective therapy therefore purpose study comprehensively review tonifying kidney yin herbs formulas reported treatment osteoporosis well agents play roles detail current study advance understanding actions tonifying kidney yin herbs formulas also provide new evidence clinic use tonifying kidney yin herbs formulas treatment osteoporosis
diesel low temperature combustion ltc great potential realization ultra low emission internal combustion engine widely studied recent years precise control ltc combustion essential real applications ltc concept diesel engine constructing model accurately describe dynamic characteristics diesel ltc foundation model based controller design paper dynamic physics based control oriented model low temperature combustion diesel engine presented model three input three output physics based control oriented model consists gas exchange sub model combustion sub model inputs model fuel rate egr opening rate vgt position outputs intake oxygen mass fraction imep model eight states states able measured easily model validated large number steady state transient diesel experimental test data steady state transient validation results show model accurately describe dynamic characteristics ltc diesel engine high accuracy control applications lays foundation model based controller design verification different control algorithms ltc diesel engine elsevier ltd rights reserved
article address increasingly important yet understudied phenomenon nonnative accentedness decision making three experimental studies investigated whether messages company delivered nonstandard american accented speech influenced choice study found individuals likely choose company product message read standard american english accent message delivered mandarin chinese french accent study found expectations regarding company messages violated speakers accents turn expectation violations mediated relationship accent choice study replicated findings effect accent choice using indian british accents also hypothesized found support conditional indirect effects model implicit pro american bias moderated indirect relationship accent choice mediated expectation violations theoretical practical implications topic study discussed
computer programming one main skills students gain graduate computer science programs however students often significant difficulties programming skills paper based survey study summarizes primary reasons students difficulties area addition methodologies seeing software big picture pair programming suggested students improve programming skills methods adapted software engineering subdisciplines
overall performance electric machine closely linked thermal design machine trend include thermal analysis machine design procedure academic literature thus also motivation prototype experimental machines accurate validations thermal analysis one challenges measure rotor temperatures online machine operation paper presents experience designing online temperature monitoring system experimental ipmsm total sensors successfully placed inside liter volume small ipmsm temperature data transmitted rotor end shaft using infrared light found online temperature monitoring system reliable used analog digital sensors exhibit equal results emi immunity placed inside electromagnetically noisy environment inside machine
objective children lateral sinus thrombosis lst following minor head injury mhi occasionally reported neuroimaging techniques however condition rare pathophysiology remains unknown aimed identify factors associated etiology severity provide information guide diagnosis management prognosis methods retrospectively reviewed patients aged years craniofacial trauma presenting emergency department total patients lst following mhi identified also performed comprehensive literature review identify relevant cases studies published yielded studies patients analyzed data patients cases results mean age cases years male female ratio nausea vomiting headache common symptoms signs symptoms increased intracranial pressure present patients sigmoid sinus commonly affected total patients treated conservatively remaining patients received anticoagulation patients good outcomes major complications radiological follow showed complete recanalization patients partial recanalization patients conclusions although lst following mhi still rare children findings indicate might much common previously thought thankfully though patients appear excellent prognosis high degree suspicion maintained assessing patients mhi non specific symptoms make diagnosis difficult neuroimaging magnetic resonance venography computed tomography venography crucial diagnosis follow hypercoagulation disorders excluded anticoagulation therapy given patients disorders persistent progressive lst conservative therapy recommended although anti edema drugs intermittent lumbar puncture may beneficial authors published elsevier open access article license http creativecommons org licenses
single wall carbon nanotubes swcnts attracted great attentions fields nanoscience nanotechnology due unprecedented physical chemical mechanical stability high dimensional aspect ratio resulting superior electrical properties however poor solubility organic aqueous solvents refrain solution processability hence practical applications present work report one pot functionalization swnct based nitrene chemistry two structurally different aromatic azides ester functional groups low concentrations thermal activation renders soluble organic solvents water resulting functionalized swcnts swcnt swcnt covalent linkage strong electronic interaction pht swcnts confirmed various spectroscopic measurements electrochemical analysis bulk heterojunction bhj photovoltaic cell based solution cast pht pcbm doping concentrations swcnts demonstrate increase power conversion efficiency respect reference cell illumination elsevier rights reserved
recently proposed anonymous two factor authentication scheme following concept temporal credential wireless sensor networks wsns claimed secure capable withstanding various attacks however reveal authentication phase scheme several pitfalls firstly scheme susceptible malicious user impersonation attack legal malicious user impersonate registered users addition scheme also vulnerable stolen smart card attack furthermore scheme provide untraceability prone tracking attack put forward untraceable two factor authentication scheme based elliptic curve cryptography ecc wsns new scheme makes missing security features necessary real life applications maintaining desired features original scheme prove scheme fulfills mutual authentication burrows abadi needham ban logic moreover way informal security analysis show proposed scheme resist variety attacks provide security features scheme
intestinal barrier integrity prerequisite homeostasis mucosal function balanced maximise absorptive capacity maintaining efficient defensive reactions chemical microbial challenges evidence mounting disruption epithelial barrier integrity one major aetiological factors associated several gastrointestinal diseases including infection pathogens obesity diabetes necrotising enterocolitis irritable bowel syndrome inflammatory bowel disease notion specific probiotic bacterial strains affect barrier integrity fuelled research vitro cell lines animal models clinical trials used assess whether probiotics revert diseased state back homeostasis health review catalogues categorises lines evidence available literature role probiotics epithelial integrity consequently beneficial effect reduction gastrointestinal disease symptoms
work sensor built smart material based polymer brush gold nanoparticles modified electrode functionalized polyacrylic acid paa tethered indium tin oxide ito covered gold nanoparticle ito paa demonstrated switchable interfacial properties discriminating different phs switchable electrochemical plasmonic process characterized cyclic voltammetry electrochemistry impedance spectroscopy eis localized surface plasmon resonance lspr
purpose investigate protective effect green tea epigallocatechin gallate egcg ultraviolet induced skin damages hairless mice order develop natural sunscreen compound use skin care products cosmetics methods egcg dissolved acetone concentrations topically applied skin hairless mice doses acetone control mice irradiated min daily egcg treatment irradiation carried daily consecutive days mice sacrificed dorsal skin examined transmission electron microscopy tem day results irradiation induced severe macroscopic skin damage including chapping cracking abnormal desquamation treated hairless mice egcg showed dose dependent protective effects induced damage skin treatments egcg alleviated induced skin damage suppressing keratinocyte apoptosis mitochondrial dysfunction along inhibiting production melanin pigment conclusion topical application green tea egcg shows dose dependent protective effect induced damage hairless mouse skin thus plant compound potentially used alternative agent photoprotection exposure
data warehousing traditional domain relational databases two main reasons data warehouses mostly used enterprises large scale data sets created different legacy systems relational data storages though rapidly developing non relational databases still rather unusual data processing tasks paper discusses possibilities create data warehouse solutions using nosql database management systems main challenge find good balance characteristics classical data warehouses using relational data base management systems opportunities offered nosql database management systems paper describes processes creation production data warehouse using nosql data mart outlines requirements technology necessary processes research based practical experience implementing nosql data marts mongodb clusterpoint authors published elsevier
across six studies people used bad black heuristic social judgment assumed immoral acts committed people darker skin tones regardless racial background immoral actors archival studies news articles written black white celebrities popular culture magazines study american politicians study critical rather complimentary stories darker skin tone photographs printed article remaining four studies participants associated immoral acts darker skinned people examining surveillance footage studies matching headshots good bad actions studies additionally found race based studies shade based studies associations badness darkness determine whether people demonstrate bad black effect discuss implications social perception eyewitness identification
paper explores influence flight altitude terrain morphology number ground control points gcps digital surface model dsm orthoimage accuracies obtained unmanned aerial vehicle uav photogrammetry study photogrammetric projects carried considering five terrain morphologies four flight altitudes three different numbers gcps uav rotatory wing platform eight motors sensor nonmetric mirrorless reflex camera root mean square error rmse used assess accuracy dsm component orthophotos components rmsex rmsey rmsexy respectively results show rmsex rmsey rmsexy influenced flight altitude terrain morphology horizontal accuracy differences terrain morphologies observed gcps used best accuracies flattest morphologies nevertheless number gcps influenced horizontal accuracy number gcps increased accuracy improved vertical accuracy influenced terrain morphology flight altitude number gcps significant influences rmsez number gcps increased accuracy improved regarding flight altitude vertical accuracy decreased flight altitude increased accurate combination flight altitude number gcps gcps respectively yielded rmsex rmsey rmsexy rmsez values equal respectively view results map scale according legacy american society photogrammetry remote sensing map standard approximately equivalent contour interval sufficient civil engineering projects american society civil engineers
detecting shape non rigid molten metal welding called weld pool visual sensing one central tasks automating arc welding processes challenging due strong interference high intensity arc light spatters well lack robust approaches detect represent shape nonrigid weld pool propose solution using active contours including prior weld pool boundary composition also apply adaboost select small set features captures relevant information proposed method applied weld pool tracking presented results verified feasibility note practitioners welding quality highly dependent human welder experiences skills gas tungsten arc welding process particular detecting shape nonrigid molten metal welding plays important role improving welding quality since provides prime feedback mechanism welding control however challenging task due number reasons strong interference changing working environment applying classical image processing algorithms directly active contour models acm guarantee satisfactory performance due mentioned reasons actually practice acm often failed capture welding pool boundary work integrate application dependent prior definition energy functional traditional acm thus allowing use machine learning techniques improve performance traditional acm density estimation prior adaboost utilized select features suitable gaussian bayesian classifiers differentiate wanted boundaries unwanted ones spurious boundaries caused interfering noise proposed approach improves perfor mance traditional acm captures boundary welding pool successfully also generalized applications need integrate application dependent priors enhance classical methods may otherwise applicable real world implementations
question kinesio taping reduce swelling athletes suffered acute lateral ankle sprain design randomised controlled trial concealed allocation intention treat analysis blinded assessment participants thirty six athletes participated regularly one seven different sports modalities suffered acute ankle sprain intervention experimental group received kinesio taping application days designed treat swelling control group received inert kinesio taping application outcome measures comparison groups swelling measured via volumetry perimetry relative volumetry two analyses difference volume perimetry ankles participant data collected immediately days intervention follow days post intervention results days intervention differences groups swelling volumetry perimetry relative volumetry analyses day follow significant group differences outcomes conclusion application kinesio taping aim stimulating lymphatic system ineffective decreasing acute swelling ankle sprain athletes australian physiotherapy association published elsevier
background autism spectrum disorders asds developmental conditions characterized deficits social interaction impairments verbal nonverbal communication stereotyped patterns behavior previous studies implicated environmental factors development asd although reliable neurophysiological network associated asd low levels plasma oxytocin oxy arginine vasopressin avp reported twin nonapeptides oxy avp mainly produced brain mammals dysregulation neuropeptides associated changes behavior especially social interactions methods previously analyzed commonly used fragrances reported significant mutagenic neurocytotoxic stimulatory effects fetal neuroblastoma cell lines nbc study analyzed neuromodifications three selected fragrances male female human fetal brain neurons utilizing immunohistochemistry results show exposure femtomolar concentrations fragrances results morphological changes light microscopy nbc importantly fragrances significantly reduced oxy avp receptor positive oxyr avpr neurons male nbc female nbc possibly contributing development male bias asd conclusion study first show potential link fragrance exposure depletion oxyr avpr neurons male bias autism elsevier inc rights reserved
paper investigates applicability reliability economic benefit rainwater harvesting rwh systems partially offset daily water demand multistoried residential buildings combination town water supply systems dhaka city comprehensive computer software developed view assessing reliability feasibility rwh systems urban setup software developed using daily water balance modelling concept uses input data like daily rainfall roof catchment area runoff losses tank volume three distinct climatic scenarios wet average dry years chosen analysing historical years daily rainfall data typical residential buildings plot size katha considered study results indicated reliability achieved wet climatic condition catchment sizes varying rainwater harvested year several reliability curves presented two roof catchment sizes three climatic scenarios insignificant increase reliability rwh system beyond tank volume observed current underground tank sizes residential buildings sufficient prevent potential overflow monsoon monetary saving around bdt achieved catchment size tank size average year climate condition monetary saving increases increase catchment size elsevier rights reserved
paper deals distributed state estimation class networked systems extends results zhou coordinated one step optimal distributed state prediction networked dynamical system ieee transactions automatic control one step state predictions introducing specific discrete state space representation distributed estimator whose number internal inputs outputs twice plant recursive explicit expressions derived respectively optimal gain matrix covariance matrix expressions similar structures state predictor obtained zhou means desired state estimator inherits computational advantages state predictor therefore suitable systems consisting large number subsystems lumped kalman filter numerical simulations show state estimator developed paper may even estimation accuracy lumped kalman filter
present study examined whether thin slice ratings child personality serve resource efficient theoretically valid measurement child personality traits extended theoretical work observability perceptual accuracy situational consistency childhood personality traits examining intersource interjudge agreement cross situational consistency convergent divergent predictive validity thin slice ratings forty five unacquainted independent coders rated children ages personality thin slice behavioral scenarios raters per slice independent thin slice ratings mothers fathers children rated children personality psychopathology competence found robust evidence correlations thin slice mother father ratings child personality within across task consistency thin slice ratings convergent divergent validity psychopathology competence surprisingly thin slice ratings consistent across situations child sample previously found adults taken together results suggest thin slices valid reliable measure assess child personality offering useful method measurement beyond questionnaires helping address novel questions personality perception consistency childhood
foetal midbrain progenitors shown survive give rise different classes dopamine neurons integrate host brain alleviating parkinsonian symptoms following transplantation patients animal models disease dopamine neuron subpopulations midbrain namely identified anatomically based cell morphology ascending axonal projections protein gated inwardly rectifying potassium channel girk calcium binding protein calbindin two best available histochemical markers currently used label overlap like dopamine neuron subtypes respectively tyrosine hydroxylase expressing neurons midbrain grafts classes dopamine neurons survive grafts striatum extend axonal projections normal dorsal ventral striatal targets depending phenotype nevertheless grafts transplanted dorsal striatum input nucleus enriched dopamine neurons express girk remains elucidated whether different transplantation sites favour differential survival development concordant dopamine neuron subtypes within grafts used rat foetal midbrain progenitors two developmental stages corresponding peak either neurogenesis examined commitment respective dopaminergic phenotypes grafting cells different forebrain regions contain targets either nigral dopamine innervation dorsal striatum ventral tegmental area dopamine innervation nucleus accumbens prefrontal cortex sparse dopamine rich noradrenaline innervation hippocampus demonstrate young embryonic day older mesencephalic tissue transplant environment influence survival functional integration specific subtypes dopamine neurons host brain also show irrespective donor age like girk expressing neurons responsive environmental cues adopting dopaminergic phenotype differentiation post grafting novel findings suggest dopamine progenitors use targets innervation transplantation site complete maturation efficacy foetal cell replacement therapy patients may improved deriving midbrain tissue earlier developmental stages current practice authors published elsevier inc
background objective inhaled corticosteroids ics inhaled corticosteroids combined long acting beta agonist ics laba standard treatments asthma however factors might help reduce medication well controlled asthma unknown classified problems asthma patients biological psychological adherence factors investigated factors associated indication failure medication step treatment methods two hundred twenty two well controlled asthma patients receiving ics ics laba assessed physical psychiatric problems followed one year adjustment treatment step factor defined presence chronic upper airway complications factor defined presence psychiatric complications sleep disorder depression anxiety somatoform disorders factor defined poor adherence ics ics laba inhaler less success step treatment defined maintenance well controlled status one year step results factor important single negative predictive factor indication step treatment odds ratio factor increased risk failure maintain step treatment significantly fold factor increased fold combination factors increased failure fold factors fold three factors fold factor interacted factors reduce chances stepping constitute problem factor present alone conclusion clinical relevance evaluation biological psychological adherence problems may lead proactive targeted approach step treatment patients well controlled asthma
investigated whether transcranial bright light tbl affects nocturnal melatonin cortisol secretion sham controlled crossover trial young healthy adults exposed random order minutes tbl sham exposure via ear canals saliva urine samples collected hourly significant differences melatonin cortisol concentrations tbl sham exposures sampling point indicating tbl via ear canals suppress nocturnal melatonin secretion thus non visual effects tbl mediated via pathway involving melatonin suppression
objectivesclinical trials oral direct acting antivirals daas chronic hepatitis virus hcv infection reported high response rates hcv hiv coinfection similar obtained hcv monoinfection evaluated safety efficacy regimens clinical practice setting methodsin prospective observational study hcv monoinfected hcv hiv coinfected patients undergoing hcv treatment oral daa regimens routine clinical setting december december included analysis sustained virological response weeks end therapy svr reported adverse events aes evaluated resistance associated variants ravs analysed subgroup patients baseline time viral rebound virological failure resultsone hundred nine patients hcv infected hcv hiv coinfected enrolled study sixty per cent cirrhosis pegylated interferon ribavirin pegifn rbv experienced thirty six per cent received ombitasvir paritaprevir ritonavir dasabuvir sofosbuvir daclatasvir sofosbuvir simeprevir sofosbuvir ribavirin sofosbuvir ledipasvir ribavirin used subjects svr rate hiv infected uninfected patients respectively week hcv viral decline similar two groups ravs found baseline patients affect svr predictors svr identified cohort conclusionstreatment oral daa combinations patients infected hcv hcv hiv real life conditions led high similar rates svr moreover historical factors associated sustained virological response pegifn rbv predictive response oral daas
concept epreuve literally translated challenge developed french sociologist danilo martuccelli inspired sartre existential philosophy phenomenological sociology concern analysing modern experiences charles wright mills conviction necessary relate personal problems social structures generate amplify concept used sociology ageing france characterise epreuve ageing four domains epreuve identified activities identity autonomy relationship world paper applies template corpus interviews people mild moderate stages alzheimer disease order characterise epreuve ageing disease epreuve ageing earlier stages disease similar experience people age without cognitive disorder however disease progresses analysis reveals tends exacerbate issues identity seems especially threatened simultaneously raising question self presentation self definition although interviewees strive retain autonomy delegate close confidante build relationship strong dependence weakened communication accentuates feeling world foreign strange
passive house first presented prof adamson lund university sweden wolfgang feist germany nowadays passive house widely used kind low energy consumption high comfort energy saving building around world passive low energy consumption green building memorandum understanding made shandong provincial housing urban rural development bureau deutsche energie agentur dena first projects classified provincial projects paper analyze building load energy consumption pingyi science museum order conform consumption index suit shandong province
currently within framework graduate education student make strong self learning work technical field task complicated difficulty contents covered make better use sessions necessary student reaches previous knowledge independently addressing truly relevant contents difficulties meetings work consists design didactic unit combining learning activities sessions order improve academic productivity new context higher education unit designed engineering field specifically subject strength materials mechanical engineering degree combining telelearning activities student acquire basic skills needed carry practical activity consisting analysis using technique photoelasticity students must attain knowledge skills necessary practice laboratory fulfill evaluation results responding questions asked teacher
coal top fuel power generation china united states replacement one critical method mitigate serious environmental impacts natural gas associated much less air pollution one important alternative fuels united state shale gas one key type unconventional natural gas become disruptive energy resource past years china world largest resource shale gas keen develop alleviate unacceptable air pollution ensure energy security however one big obstacle standing ambition reality potentially serious environmental impacts caused shale gas development construct analytical framework focusing coverage implementability monitoring reporting verification mrv systems qualitatively evaluate probability detecting noncompliance enhancing compliance china united states three prominent environmental impacts including water contamination water consumption methane leakage china improve significantly implementability dimension pay urgent attention currently weak mrv systems water contamination united states needs extend mrv coverage ground water consumption environmental impacts shale gas development effectively controlled fuel switching replace coal could bring significant environmental gains elsevier rights reserved
objectives investigation conducted determine whether contesting orientations add predictive utility prosocial behavior sports beyond variables related component processes moral action design cross sectional methods intercollegiate athletes male individual team sports completed measures contesting orientation three moral variables moral attentiveness moral identity integrity three sport specific variables athletic identity goal orientation fear failure three outcome variables sportspersonship academic honesty prosocial helping data analyzed using correlational regression analyses results regression analyses demonstrated contesting orientations best predictors sportspersonship insignificant predictors nonsport forms prosocial behavior conclusions consistent contesting theory contesting orientation salient potent predictors sportspersonship predict behavior outside contest situations elsevier ltd rights reserved
report detailed investigation effect carbon black morphology network formation evolution high density polyethylene composites three types networks study electrical network solid state electrical rheological networks melt state evolution network polymer melt traced simultaneous electrical resistivity dynamic rheology testing oscillation strain sweep used investigate network stability large strain found high structure branched morphology easier form filler polymer filler filler network low structure spherical morphology composite melt high structure network stable large strain compared low structure one meanwhile low structure aggregates stronger capability movement aggregation polymer melt wiley periodicals inc appl polym sci
background myc essential gene multiple functions cell growth differentiation apoptosis genomic stability angiogenesis disease biology large number researchers dedicated myc biology generating substantial amount data normal cancer cells tissues including burkitt lymphoma ovarian cancer results mycbase http bicresources jcbose ssaha mycbase collection experimentally supported functional sites myc influence biological cellular processes functional sites compiled according role includes mutation methylation pattern post translational modifications proteinprotein interactions ppis dna interactions addition biochemical properties myc also compiled includes metabolism pathway protein abundance modulators protein protein interactions omics data related myc like gene expression proteomics expression using mass spectrometry mirnas targeting myc also compiled mycbase mutation pathway data mycbase analyzed look patterns distributions across different diseases proteins genes found common myc protein interactions myc dna binding play significant role transcriptional feedback loops conclusion report present comprehensive integration relevant information regarding myc form mycbase data compiled mycbase provides reliable data resource functional sites residue level biochemical properties myc various cancers
background osteoporosis common extra pulmonary complication chronic obstructive pulmonary disease copd may related general causes copd specific causes low forced expiratory volume fev hypoxia studies reported emphysema independent risk factor osteoporosis however workers considered association confounded low fev low body mass index bmi cluster emphysema aims study association osteoporosis emphysema model includes potentially confounding factors methods studied prospectively copd patients high resolution computed tomography carbon monoxide diffusion coefficient diagnostic markers emphysema dual energy ray absorptiometry used measure bone mass density bmd lumbar vertebrae neck femur vertebral fractures evaluated using genant semiquantitative score multiple linear regression analysis used identify following independent variables age bmi fev predicted pao emphysema score reactive protein crp dyspnea score related bmd considered statistically significant results significant difference serum vitamin levels vertebral fracture score bmd emphysematous nonemphysematous patients multivariate analysis showed model including age bmi fev pao emphysema score crp dyspnea score reduced bmi fev pao independent risk factors low bmd conclusions emphysematous phenotype risk factor osteoporosis independently bmi fev pao
electrical machines design studies found literature lie concept design investigation optimization focuses mainly geometrical aspects machine thus takes account certain ferromagnetic material iron parts studies give little information influence material alternatives optimized design manufacturers point view though information crucial especially nowadays lot commercially available materials market context paper presents results research project design stage energy efficient three phase squirrel cage induction motor scim investigating effects several soft magnetic materials adopted stator rotor parts multiple quantities primary concern efficiency power factor output torque losses weight cost brief proposed design procedure total twenty two different materials recent manufacturers data examined also main electromagnetic analysis performed commercial analysis software simple ranking methods also proposed different application areas results obtained thoroughly discussed commented
nuclear fusion one newest promising clean safe energies hence imposes new research area control paper design multivariable adaptive proportional integral derivative pid controller control plasma current shape position ensure safe operation fusion reactor successfully developed recursive least square algorithm used alternative way adaptation mechanism tuning pid controller gains since stability vital issue evaluation control systems therefore stability analysis proposed controller developed using lyapunov stability theory main objective plasma current shape position controller fusion reactors improve stability performance tokamak magnetic systems without contravening limits imposed actuating coils voltages physical limitations proposed apid adaptive pid controller tunes online parameters cope presence disturbance parameters changes occur operation results proposed apid simulation code tokamak show noteworthy improvement respect obtained control techniques cases changing initial controller gains adding disturbance signal variation reactor model parameters
paper investigates distribution intergranular forces within uncemented mine backfills using discrete element method dem compares existing analytical method virtual backfilling modeled via dem simulate underground mining stopes backfilling uncemented granular materials normal shear forces particle contacts within model backfill tracked analyzed particular attention effect sidewall friction dem evaluates normal force chains reveals concentration high forces within model backfill dem shows profiles forces distinctly different obtained analytical solutions quantitative analyses spatial distribution forces number contact points changes orientation forces presented dem demonstrates capacity good tool looking closely backfill particle scale highlights potential force distribution concentration within backfill shows limitations analytical solutions helps engineers mining industry better understand possible mechanisms within backfill american society civil engineers
study presents first attempt link multi algorithm genetically adaptive search method amalgam groundwater model define pumping rates within well distributed set pareto solutions pumping rates along three minimization objectives minimizing shortage affected failure supply modified shortage index minimization extent drawdown within prespecified regions chosen define optimal solution groundwater drawdown subsidence hydraulic conductivity specific yield parameters modular threedimensional finite difference modflow groundwater model first optimized using cuckoo optimization algorithm coa minimizing sum absolute deviation observed simulated water table depths parameters applied amalgam optimize pumping rate variables arid groundwater system iran pareto parameter sets yielded satisfactory results maximum minimum drawdowns aquifer defined range year overall modelling optimization simulation procedure capable compute set optimal solutions displayed pareto front proposed optimal solution provides sustainable groundwater management alternatives decision makers arid region
queer theories anti futurity maddened cripped reinserting disability trauma child abuse analysis queer time queer temporalities traumatized mind including dissociation amnesia hypervigilance ongoing disorientation time explored resisting imperative cure queer time traveling trauma positioned means queer mad world making commitment justice
study proposes algorithm calculating outputs stepless tunable four chip led according black body radiation curve proposed algorithm based generalized reduced gradient method lumen outputs four chip leds calculated real time color temperatures ranging without using lookup table enabling achieving high quality lighting designs finally algorithms stepless dimming method average color shift duv proposed algorithm much smaller memory size requirements microcontroller unit current method
much software engineering research needs provide implementation proof concept often implementations created exploratory prototypes without polished user interfaces making difficult run user studies validate tool contribution validate author claim fellow scientists demonstrate utility value research contribution interested parties however turning exploratory prototype proper tool end users often entails great effort heavyweight mainstream frameworks eclipse address issue steep learning curves constitute substantial entry barriers ecosystems paper present model analyzer checker mach stand alone tool command line interpreter mach integrates set research prototypes analyzing uml models choosing simple command line interpreter rather costly graphical user interface achieved core goal quickly deploying research results broader audience keeping required effort absolute minimum analyze mach case study requirements constraints academic environment influence design decisions software tool development argue approach perhaps unconventional serves purpose remarkable cost benefit ratio elsevier rights reserved
backgroundlittle known factors trigger contribute hereditary angioedema ace inhibitor mediated angioedema including variations bradykinin type receptor expression activity methodsprotein mrna expression increase intracellular calcium ica response bradykinin monitored porcine murine endothelial cells response donors bradykinin protein expression evaluated skin heart lung mice endothelial specific overexpression enos enos enos mice iii cbl mice treated donor pentaerythritol tetranitrate petn nos inhibitor nitroarginine plasma pool inh antagonist icatibant aortic reactivity bradykinin investigated including enos mice resultsbr protein mrna expression remained unchanged cells subjected donors bradykinin time concentration dependent manner likewise increases ica murine brain endothelial cells remained unchanged protein levels similar enos enos compared transgene negative littermates likewise treatment cbl mice petn inh icatibant change protein expression aortic rings cbl mice bradykinin induced dependent constrictions attenuated endothelial abolished diclofenac indicating functional importance induced activation endothelial synthase cyclooxygenase conclusionthese data suggest alterations protein expression induced bradykinin inh icatibant unlikely contribute bradykinin induced angioedema finding rule role bradykinin induced extravasation angioedema
polyacrylamide based conditioners become essential component geotextile tube dewatering processes conditioners act flocculants binding fine sediments charge neutralisation particle bridging resulting faster dewatering rates greater retention fine sediments recently however momentum begun shift towards use sustainable materials natural flocculants starch chitosan increasingly tested attractive alternative synthetic polymers researchers identified number natural flocculants polysaccharides polysaccharide derivatives particular candidates dewatering applications study dewatering performance four soils sand silt kaolin natural organic soil evaluated synthetic starch based flocculants dewatering performance five cationic starch based polymers charge densities ranging meq molecular weights ranging mol mol compared five cationic acrylamide based polymers charge densities ranged meq molecular weights ranged mol cationic polyacrylamides cationic starches selected wide range charge densities molecular weights order study effect flocculant properties flocculation dewatering performance used soils optimum dose flocculant determined using jar test additionally pressure filtration tests performed determine dewatering rates filter cake properties test results showed flocculants properties especially charge density significant effect optimum dose optimum doses cationic starch flocculants two four times higher cationic polyacrylamide polymers additionally found cationic starches effective minimising turbidity natural organic soils cationic polyacrylamides finally cationic starches allowed increase dewatering rate comparison soil samples tested without flocculants
background studies examined cardiovascular outcomes patients diabetes gout diabetes gout risk factors cardiovascular disease objective study examine effect allopurinol risk incident acute cardiovascular events patients gout diabetes methods used multi payer claims database mpcd linked health plan data national commercial governmental insurances representing beneficiaries united healthcare medicare medicaid coverage patients gout diabetes assessed current allopurinol use defined new filled prescription allopurinol main predictor interest outcome interest occurrence first incident hospitalized myocardial infarction stroke composite acute cardiovascular event observations censored employed multivariable adjusted cox proportional hazards models simultaneously adjusted patient demographics cardiovascular risk factors medical comorbidities calculated hazard ratios confidence intervals incident composite stroke acute cardiovascular events performed sensitivity analyses additionally adjusted presence immune diseases colchicine use potential confounders results person days person years current allopurinol use person days person years prior allopurinol use incident mis strokes current prior allopurinol users respectively compared previous allopurinol users current allopurinol users significantly lower adjusted hazard incident acute cardiovascular events incident stroke sensitivity analyses additionally adjusted immune diseases colchicine use confirmed association conclusions current allopurinol use protected occurrence acute cardiovascular events patients gout diabetes underlying mechanisms potential cardio protective effect allopurinol need exploration
online social networks osns become popular attracted great many users friend recommendation one important services osn help users discover interested friends alleviate problem information overload however existing recommendation methods consider either user link content information hence effective enough provide high quality recommendations paper propose topic community based method via nonnegative matrix factorization nmf method first applies joint nmf model mine topic communities existing osn combing link content information computes user pairwise similarities makes friends recommendation based topic communities furthermore method implemented using mapreduce distributed computing framework extensive experiments show proposed method better recommendation performance state art methods also good scalability deal problem friend recommendation large sale osns moreover application case demonstrates significantly improve friend recommendation service real world osn copyright john wiley sons ltd
paper discusses automated visual identification individual great white sharks dorsal fin imagery propose computer vision photo system report recognition results database thousands unconstrained fin images best knowledge line work establishes first fully automated contour based visual system field animal biometrics approach put forward appreciates shark fins textureless flexible partially occluded objects individually characteristic shape order recover animal identities image first introduce open contour stroke model extends multi scale region segmentation achieve robust fin detection secondly show combinatorial scale space selective fingerprinting successfully encode fin individuality measure species specific distribution visual individuality along fin contour via embedding global fin space exploiting domain finally propose non linear model individual animal recognition combine approaches fine grained multi instance framework provide system evaluation compare results prior work report performance properties detail
introduction cannabis users higher risk mental disorder general population however remains shortage research examines relationship reluctance seek mental health treatment subsequent frequent cannabis use study evaluates whether negative attitudes toward mental health treatment attitudinal barriers predict high frequency cannabis use whether using cannabis cope mental health symptoms coping motives explains relationship methods participants students washington state university wsu received violations illegal cannabis use possession data collected participants days mandated two part course cannabis harm reduction cross sectional path analysis performed assess whether coping motives mediated relationship attitudinal barriers mental health treatment frequency cannabis use controlling mental health symptoms results coping motives fully mediated relationship negative attitudes toward treatment frequency use indirect effect beta bootstrap direction results confirmed switching mediator criterion variable model fit well data rmsea cfi srmr conclusions reluctance seek mental health treatment may related higher levels cannabis use coping motives addressing attitudes toward mental health treatment may alternative way decrease frequency use possibly promote mental health treatment seeking behaviors needed studies needed confirm implications finding published elsevier ltd
tall buildings ubiquitous major cities house homes workplaces many individuals however relatively studies carried study dynamic characteristics tall buildings based field measurements paper dynamic behavior green building unique story tall structure located campus massachusetts institute technology mit cambridge usa characterized modeled simplified lumped mass beam model slmm using data network accelerometers accelerometer network used record structural responses due ambient vibrations blast loading october earthquake near hollis center usa spectral signal coherence analysis collected data used identify natural frequencies modes foundation rocking behavior structural asymmetries relation foundation rocking structural natural frequencies also found natural frequencies structural acceleration field measurements compared predicted slmm updated inverse solving based advanced multiobjective optimization methods using measured structural responses found good agreement
least squares support vector machine svm emerged popular data driven modeling method extensively studied machine learning community however svm sensitive noisy data may effective level noise high paper probabilistic svm proposed reliable performance first distributed svm constructed parameters estimated data samples due distributed nature multiple svm stochastic property parameters easily obtained processed using distribution characteristics parameters final outcome derived probabilistic inference thus evaluated statistically parallel structure also suitable parallel computing reduce computing time simulations experiments demonstrate effectiveness proposed probabilistic svm
objectivethis study aimed assess relationship emotional social support emotional well among latina immigrants breast cancer test whether two culturally relevant coping strategies fatalism acceptance mediate relationship methodsone hundred fifty spanish speaking latinas within year breast cancer diagnosis participating randomized trial stress management intervention assessed person baseline via telephone months later survey measures included baseline emotional support fatalism acceptance emotional well months later generalized linear models estimated direct effects emotional support emotional well indirect effects fatalism acceptance resultsmean age years women low education acculturation levels emotional support negatively associated fatalism positively associated acceptance emotional support acceptance positively associated emotional well whereas fatalism negatively associated emotional well multivariable models emotional support associated emotional well direct effect remained significant additionally controlling fatalism acceptance separate models significant indirect effect emotional support emotional well fatalism well marginally significant effect acceptance conclusionsemotional support may increase well among spanish speaking latina cancer survivors reducing cancer fatalism copyright john wiley sons ltd
background idiopathic pulmonary fibrosis ipf devastating disease characterized unpredictable course prognostic markers disease activity markers needed purpose single center retrospective study evaluate prognostic value lung fluorodeoxyglucose fdg uptake assessed standardized uptake value suv metabolic lung volume mlv total lesion glycolysis tlg patients ipf methods included ipf patients ipf group patients gastrointestinal neuroendocrine tumor without thoracic involvement control group quantified lung suv mean suv max mlv tlg assessed clinical data high resolution hrct fibrosis ground glass score lung function gender age physiology gap stage inclusion follow survival results lung suv mean suv max higher ipf patients controls patients ipf suv mean suv max mlv tlg correlated severity lung involvement measured decline forced vital capacity fvc diffusing capacity lungs carbon monoxide dlco increased gap score univariate multivariate cox proportional hazards model risk death increased although significantly high suv mean univariate analysis risk death significantly associated high tlg mlv disappeared adjustment functional variables gap index increased mlv tlg independent predictors death disease progression months pet scan completion every point increase tlg hazard ratio every point increase mlv multivariable analysis including tlg mlv age fvc dlco gap index tlg mlv remained associated progression free survival conclusion fdg lung uptake may marker ipf severity predict progression free survival patients ipf
prevalence depression anxiety chinese male population infertility still uncertain prevalence depression anxiety combination psychological symptoms respectively infertile chinese men current study mental health inventory state trait anxiety inventory short form questionnaires differences demographics age education income noticeable impact development psychological symptoms clinical factors concomitant disorders varicocele epididymal cyst erectile dysfunction identified risk factors associated depressive symptoms depressive anxiety symptoms infertility duration years associated high risk anxiety symptoms clinical conditions type treatment quality sperm significant risk factors psychological symptoms study provides evidence chinese men reproductive age suffer infertility vulnerable psychological distress
background objective prevalence selected psychiatric disorders depression anxiety higher patients psoriasis however association psoriasis schizophrenia less clear investigated whether prevalence schizophrenia higher patients psoriasis methods cross sectional study analyzed million person cohort enrolled taiwan national health insurance research database psoriasis schizophrenia comorbidities ascertained international classification diseases revision clinical modification coding schizophrenia concomitant catastrophic illness certificate used verify diagnosis prevalence schizophrenia patients psoriasis compared prevalence schizophrenia comparable population using generalized linear mixed model results prevalence schizophrenia significantly higher patients psoriasis comparison population prevalence ratio confidence interval within psoriasis cohort patients aged years years higher odds ratio schizophrenia furthermore psoriatic patients comorbid cerebrovascular disease chronic pulmonary disease higher odds schizophrenia conclusion schizophrenia prevalent patients psoriasis although exact mechanisms remain clarified finding psoriatic patients comorbid cerebrovascular disease chronic pulmonary disease higher odds schizophrenia may imply psoriatic patients comorbidities likely higher inflammatory burden would contribute development schizophrenia disruption bloodbrain barrier present investigations indicated validate hypothesis explaining association known comorbidies psoriasis schizophrenia copyright taiwanese dermatological association published elsevier taiwan llc
objective retrospective study evaluate incidence infectious adverse events patients psoriasis treated etanercept methods patients psoriasis psoriatic arthritis treated etanercept administered weekly via subcutaneous injection weeks retrospectively enrolled patients screened occult infections treatment commenced every months thereafter minor requiring hospitalization discontinuation treatment major requiring hospitalization discontinuation treatment infectious events recorded results study included patients minor infectious events included self limiting upper respiratory tract infections six patients lower urinary tract infections one patient recurrent herpes simplex labialis two patients major infections occurred two cases conclusion data support good safety profile etanercept patients psoriasis psoriatic arthritis
indirect immunofluorescence iif using human epithelial cell hep substrate widely used recommended method screening antinuclear antibodies ana dense fine speckled dfs pattern hep widely reported various healthy disease groups interpretation dfs pattern challenging conventional hep substrate due similarity disease associated patterns high prevalence dfs autoantibodies normal population lack association particular disease group general negative association systemic ana associated autoimmune rheumatic diseases sard aard necessitates confirmation dfs pattern results using available commercial assays confirmation dfs autoantibodies always agree iif screening results complicating lab work flow ana algorithms review discuss prevalence dfs antibodies factors affecting performance iif dfs specific confirmatory assays factors contribute disagreement dfs suspicion iif confirmatory assays also discussed addition also describe novel iif hep substrate positive impact dfs reporting ana screening confirmation algorithm
energy storage unique provide multiple services feature raises cost recovery issues storage due combination competitive markets ratebased cost recovery used many power systems today hybrid regulatory paradigm relies classifying assets providing competitively prices unpriced services handling cost recovery based classification recent regulatory precedents suggest storage developers must choose classifying assets providing competitively priced unpriced services former case storage costs must recovered market asset classified providing unpriced services costs recovered ratebase regulatory design hamper cost recovery storage may lead inefficient storage investment use propose alternate solution whereby storage capacity rights auctioned third parties use rights priced unpriced services storage capacity rights disentangle storage cost recovery regulatory treatment end use formulate storage capacity auction model demonstrate efficiently price storage capacity rights show revenues earned storage owner auction equals imputed marginal value storage capacity revealed market bids
second part review provides flexible approach integrative neuromuscular training int goals improve injury resilience enhance sport motor performance abilities youth populations proposed model int manuscript presents essential components dynamic stability lower limb core strength plyometrics coordination speed agility fatigue resistance development capacities integral establishing important foundation initially developing fundamental movement skill competency building upon skills enrich sports specific activity specific skill sets video abstract article see supplemental digital content see video http links lww com scj
study examines new york times los angeles times press coverage contraception one key period first years passage comstock act difficult contraception advocates new york times narrative reflected battle supported comstock act men women opposed conversely los angeles times narrative portrayed birth control debate wide ranging battle ideas occurring variety venues press coverage revealed use birth control common real debate access whether information publicly available battle began contemporary press coverage reveals debate birth control continues
self healing self sensing performances engineered cementitious composite ecc mixtures developed recently heriot watt university presented first series experiments fifteen dog bone shaped ecc samples preloaded known strains left heal outdoors natural environment ultrasonic pulse velocity measurements undertaken periodically determine rate extent healing samples found samples able heal micro cracks show recovery upv two loading events six month outdoor exposure another series experiments effectiveness incorporating milled carbon fibers ecc mix aim enhancing self sensing functionality ecc demonstrated first time ecc mix exhibited equivalent tensile response compared control ecc mix displayed strong relationship tensile strain fractional change resistivity inclusion fibers volume found exhibit high sensitivity micro cracks formation gauge factor two orders magnitude larger ordinary strain gauge albeit less control mix envisaged use ecc create intelligent infrastructure able sense repair damage monitor recovery extent published elsevier ltd open access article license http creativecommons org licenses
many countries europe north america see natural agricultural landscapes replaced fragmented sprawled landscape spatially detailed modelling changes land use population transport could help forecast impact scenarios aimed mitigating process urban sprawl common problem land use change models however lack historical data proper model calibration paper describe approach developing historical population density maps downdating recent high resolution population density raster using time series sealed surface data historical census data input proposed approach hypothesise local relationship increasing population densities increasing sealed surface fraction estimates latter obtained remote sensing imagery apply method flanders belgium region population growth improved transport networks led diffuse urban expansion ribbon development along many roads strong fragmentation open space resulting population sealed surface maps provide interesting data urban sprawl phenomenon past decades computing densification index observe urban areas witness recent population density increase several rural areas built area per inhabitant still growing downdated time series population maps obtained study used set historical calibration activity based cellular automata model flanders brussels among data needs high resolution population maps elsevier rights reserved
based fuzzy decision theory multi objective fuzzy optimization done dynamic isolation model scheme self anchored cable stayed suspension bridge using two comparison theory solves problem quantifying qualitative indexes distinguish concepts importance superiority combining fuzzy decision method engineering practice using results five cases proposed multi objective fuzzy optimization comparison results show reasonable place lead rubber bearings pier girder also main tower girder viscous dampers main tower girder time method provide reference structure selection practical conceptual design phase
number protein structures pdb database increasing fold since creation computational models predicting enzymatic function major importance since models provide means better understand behavior newly discovered enzymes catalyzing chemical reactions single label classification widely performed predicting enzymatic function limiting application enzymes performing unique reactions introducing errors multi functional enzymes examined indeed enzymes may performing different reactions hence directly associated multiple enzymatic functions present work propose multi label enzymatic function classification scheme combines structural amino acid sequence information investigate two fusion approaches feature level decision level assess methodology general enzymatic function prediction indicated first digit enzyme commission code six main classes enzymes pdb database proposed single label multi label models predict correctly actual functional activities based hamming loss cases respectively also multi label model predicts possible enzymatic reactions multi labeled enzymes number reactions unknown
research indicates authoritarians tend avoid intergroup contact study tested hypothesis living neighbourhood higher proportion asian peoples increases likelihood contact majority new zealand europeans effect increase intergroup contact authoritarians multi level random coefficient modelling data new zealand attitudes values study indicated new zealand europeans high authoritarianism neighbourhoods high proportion asian peoples contact asian friends relative authoritarians less ethnically diverse areas copyright john wiley sons ltd
project develop accelerator driven system ads nuclear waste transmutation launched chinese academy sciences cas since three stages china lead based reactor clear selected reference reactor casads project means lead lead bismuth used primary coolant reactor institute nuclear energy safety technology inest cas one leading teams involved ads project taking charge design activities clear series reactors according research development roadmap clear mwth lead bismuth cooled pool type research reactor named clear coupled proton accelerator constructed first stage second stage china lead based engineering demonstration reactor clear mwth constructed third stage china lead based commercial prototype reactor clear iii mwth constructed order verify key components investigate thermal hydraulics phenomena clear even pool type lead based reactor integrated multifunctional non nuclear test facility named clear built commissioning end note clear used test prototype components clear primary pump heat exchanger control rod driven system vessel refueling system verify design safety analysis codes paper design description latest progress presented clear authors international journal energy research published john wiley sons ltd
intersections known integral complex nature due variety participants behaviors interactions paper presents review recent studies behavior intersections safety analysis three types participants intersections vehicles drivers pedestrians paper emphasizes techniques strong candidates automation visual sensing technology new behavior safety classification presented based key features used intersection design planning safety addition performance metrics introduced evaluate different studies insights provided regarding state art inputs algorithms challenges shortcomings
evaluated ruxolitinib patients myelofibrosis according age sex time diagnosis grade fibrosis prognostic score risk janus kinase jak status primary secondary myelofibrosis previous treatment dosage outcome measures response rate time response duration response event free survival survival kaplan meier curves show significant difference event free survival according prognostic score favor patients low int cox stepwise model confirmed result int high risk score powerful negative independent parameter followed jak parameters diagnosis years earlier grade iii fibrosis ruxolitinib dose negligible impact time response shorter primary myelofibrosis conclusion ruxolitinib effective better outcome patients low int risk score may suggest considering earlier administration disease course
let collection string documents characters total drawn alphabet set top document retrieval problem preprocess data structure given query return documents relevant pattern relevance captured using predefined ranking function depends set occurrences example term frequency number occurrences term proximity distance closest pair occurrences pattern independent importance score pagerank linear space optimal query time solutions already exist general top document retrieval problem compressed compact space solutions also known ranking functions term frequency importance however space efficient data structures term proximity based retrieval evasive paper present first sub linear space data structure relevance function uses bits top compressed suffix array solves queries time also show scores consist weighted combination term proximity term frequency document importance handled using twice space required represent text collection
tobacco smoking preventable environmental factor contributes wide spectrum age related health outcomes however association development frailty yet well established examined associations self reported smoking indicators serum cotinine levels smoking related dna methylation biomarkers quantitative frailty index independent subsets older adults age recruited saarland germany discovery set validation set obtained dna methylation profiles whole blood samples illumina humanmethylation beadchip calculated according method mitnitski rockwood mixed linear regression models implemented assess associations smoking indicators controlling potential covariates current smoking cumulative smoking exposure pack years time smoking cessation years significantly associated value discovery panel previously identified smoking related cpg sites associated correction multiple testing fdr nine survived validation phase designated frailty associated loci smoking index based loci manifested monotonic association conclusion study suggested epigenetic alterations could play role smoking associated development frailty identified cpg sites potential prognostic biomarkers frailty frailty related health outcomes findings underlying mechanisms followed preferably longitudinal studies
objective unsettling aspect opioid epidemic high rate utero exposure especially since pregnancies unintended due part low rates effective contraceptive use among opioid using women study tested intervention informed behavioral economic theory aimed promoting effective contraceptive use among opioid maintained women risk unintended pregnancy burlington area methods thirty one women assigned initial consecutively subsequent randomly either usual care experimental intervention participants usual care received condoms dose emergency contraception referral local providers participants experimental condition received usual care plus world health organization contraception initiation protocol including free prescription contraceptives financial incentives attending follow visits months help manage side effects issues results significantly women experimental usual care control conditions initiated prescription contraceptive use reported prescription contraceptive use month month month assessments none experimental condition participants became pregnant month protocol three women control condition conclusions results provide first experimental evidence supporting efficacy intervention increasing prescription contraceptive use among opioid maintained women risk unintended pregnancy elsevier inc rights reserved
objective review pharmacology clinical data brexpiprazole schizophrenia major depressive disorder mdd data sources english language literature search using pubmed medline performed using term brexpiprazole articles containing human clinical trial data published september evaluated inclusion well information manufacturer product labeling study selection data extraction phase trials brexpiprazole evaluated key vitro animal data incorporated pharmacology pharmacokinetic sections appropriate data synthesis four phase trials evaluated use brexpiprazole primary therapy schizophrenia antidepressant adjunct mdd schizophrenia indication brexpiprazole studied placebo controlled trials approximately patients brexpiprazole consistently showing superiority placebo mdd brexpiprazole compared placebo adjunct antidepressants approximately patients failed trials prior antidepressants dosages brexpiprazole showed consistent superiority placebo mdd trials common treatment emergent adverse effects included akathisia weight gain conclusions brexpiprazole showed efficacy treatment schizophrenia range adjunct antidepressant therapy mdd dosed advantages drug include daily dosing good tolerability lack effect sexual function disadvantages include lack long term safety data potentially high cost
glial cell line derived neurotrophic factor gdnf neurturin nrtn bind receptor complex consisting member gdnf family receptor gfr alpha ret tyrosine kinase factors shown protect nigro striatal dopaminergic neurons reduce motor symptoms applied terminally toxin induced parkinson disease models however clinical trials based intraputaminal gdnf protein administration recombinant adeno associated virus raav mediated nrtn gene delivery disappointing review several factors could limited clinical benefits discussed retrograde transport gdnf nrtn dopaminergic neurons soma thought necessary nrtn gfr alpha ret signaling mediating pro survival effect therefore feasibility treating advanced patients neurotrophic factors questioned recent data showing tyrosine hydroxylase positive putaminal innervation almost completely disappeared years post diagnosis patients enrolled raav nrtn trial years post diagnosis nrtn almost transported substantia nigra pars compacta addition anti apoptotic neurotrophic properties gdnf also interferes dopamine homeostasis via time dose dependent effects stimulation dopamine neuron excitability inhibition dopamine transporter activity tyrosine hydroxylase phosphorylation inhibition tyrosine hydroxylase transcription depending delivery parameters net result intricate network regulations could either beneficial deleterious conclusion unraveling mechanism action gdnf gene delivery relevant animal models still needed optimize clinical benefits new therapeutic approach recent developments design regulated viral vectors allow finely adjust gdnf dose period administration finally new clinical studies less advanced patients warranted evaluate potential aav mediated neurotrophic factors gene delivery facilitated demonstration safety raav administration human brain
paper addresses development data acquisition command daq board crane system nonlinear multi input multi output system poses interesting problems design efficient control strategies thus crane platform aimed didactic activities control engineering laboratories main board design objectives easy operation access implementation testing control algorithms validating daq board developed successfully tested two control structures one conventional proportional integral derivative pid laws one fuzzy intelligent controllers
epigenetic regulation hematopoiesis field rapid expansion genome wide analyses revealed continue identify genetic alterations epigenetic genes present various types hematopoietic neoplasms development new mouse models individual epigenetic modifiers revealed novel sometimes unexpected functions review provide overview genetic alterations within epigenetic genes various types hematopoietic neoplasms summarize physiologic roles epigenetic modifiers hematopoiesis describe therapeutic approaches targeting epigenetic modifications interestingly mutational spectrum epigenetic genes indicates myeloid neoplasms similar cell neoplasms whereas cell lymphomas distinct features furthermore appears epigenetic mutations related active transcription associated myeloid cell neoplasms whereas repress transcription associated cell lymphomas observations may imply global low level high level transcriptional activity underlies development myeloid cell tumors cell tumors respectively
books leccion anatomia daniela astor caja negra marta sanz carries thorough analysis gender construction sexual identity women teenagers grew spanish transition belief identity result communal story led examine gender construction dual perspective one hand accomplished personal inquiry autobiographical text tried demythologize false collective discourse sexual liberation transitional destape article analyzes literary protagonists assume traditional female roles harmful women liberation embody contrary new model terms sexuality maternity gender roles core families couples short study original ideological literary proposal author advocates desnudo alternative counter discourse hegemonic discourse represented destape
purpose aim study assess value dual time point imaging pet detection biochemically recurrent persistent prostate cancer using prostate specific membrane antigen psma ligand psma methods patients underwent psma pet context biochemical relapse prostate cancer included retrospective analysis imaging consisted standard whole body pet followed delayed imaging abdomen psa stratified proportions positive pet results standardized uptake values target background ratios analyzed compared standard delayed imaging results overall detection rates psma pet psa levels respectively although target background ratio improved significantly time majority lesions suggestive recurrent disease could already detected standard imaging delayed imaging exclusively identified pathologic findings abnormal psma pet scans exclusively detected lesions suggestive recurrent disease psma pet shows high detection rates patients prostate specific antigen persistence biochemical recurrence prostate cancer delayed imaging detect lesions improved contrast compared standard imaging however impact detection rates limited study
overall investigation children health status residential thermal environment pollutants conducted homes primary school children winter summer shanghai china houses divided group unhealthy child living group healthy child living two week monitoring period winter indoor temperatures group significantly lower group degrees relative humidity group higher group group around winter bad thermal environment group risk factor children health average winter concentrations ppm group ppm group houses poor ventilation nighttime indoor concentrations formaldehyde hcho acetaldehyde tvoc generally satisfied chinese national standards however indoor concentrations group higher group concentrations investigated houses exceeded chinese national standards winter dibutyl phthalate dbp ethylhexyl phthalate dehp house dust four living rooms showed high concentrations times recommended limit aspergillus cladosporium room air house dust linked high could suspected association poor children health study provides comprehensive information indoor thermal environmental conditions houses shanghai exposures primary schoolchildren health risks elsevier ltd rights reserved
present study activities components formation enthalpies binary solutions calculated molecular interaction volume model mivm contributing investigating deeply removal impurities silicon solutions wagner self interaction parameters dilute silicon solutions tried use mivm predicted activities formation enthalpies compared reported experiment data literature show thermodynamics properties binary silicon solutions accurately predicted model provide effective verification forecast experiment
aortic stenosis common valvular heart disease leading intervention typically disease elderly recent clinical advances expanded role transcatheter aortic valve intervention patients severe aortic stenosis making aortic valve intervention feasible effective even patients intermediate high prohibitive surgical risk rapid advances treatment proper diagnosis becomes crucial wide range patients aortic stenosis concordant high gradient aortic stenosis discordant low gradient aortic stenosis latter group commonly presents clinical challenge requiring thoughtful comprehensive evaluation determine eligibility aortic valve intervention providers levels familiar basic diagnostic caveats misconceptions evaluating patients possible aortic stenosis elsevier inc rights reserved
osteoporosis multifactorial debilitating disease resulting decreased bone mineral density bmd loss tissue microarchitecture ineffective therapies may lead bone fractures subsequent death single nucleotide polymorphisms snps key immune regulator genes associated therapeutic response bisphosphonates first therapeutic line choice osteoporosis however cytokine pathways relation therapeutic adhesion remain fully elucidated aimed better understanding processes investigated response bisphosphonate therapy postmenopausal women four snps key proinflammatory cytokines genes ilr ila ilb inf gamma total patients treated bisphosphonate followed period years genotyped compared according changes bone mineral density bmd level biochemical markers treatment inf gamma associated increased bmd values femoral neck decreased bmd values total hip relation biochemical markers inf gamma snp associated increased alkaline phosphatase parathyroid hormone levels vitamin values changes related ila ilb snps besides significant differences changes calcium levels correlated ilr genotypes altogether suggest polymorphisms may play important role therapeutic decisions osteoporosis treatment
combining phylogenetic network methodologies potential better inform targeted interventions prevent treat infectious diseases study reconstructed molecular transmission network people recent hepatitis virus hcv infection modelled impact targeting directly acting antiviral daa treatment hcv network participants selected three australian studies recent hcv hcv sequence data core participants time recent hcv detection analysed infer network connecting pairs sequences whose divergence substitutions site logistic regression used identify factors associated connectivity impact targeting hcv daas hiv infected random nodes simulated million replicates among participants connected network hcv hiv infected participants likely connected compared hcv mono infected participants simulations targeting daa hcv treatment hcv hiv infected individuals prevented times onward infections providing daas randomly selected individuals results demonstrate genetic distance based network analyses used identify characteristics associated hcv transmission informing targeted prevention treatment strategies
aimsto identify trajectories heroin use australia predictors trajectory group membership subsequent outcomes among people heroin dependence years designlongitudinal cohort study settingsydney australia participantsa total participants recruited part australian treatment outcome study male mean age years predominance cohort recruited upon entry treatment maintenance therapies detoxification residential rehabilitation remainder non treatment settings needle syringe programmes analysis focused upon participants data heroin use available years following study entry measurementsstructured interviews assessed demographics treatment history heroin drug use overdose criminal involvement physical health psychopathology group based trajectory modelling used identify trajectory groups based use heroin year examine predictors group membership iii examine associations trajectory group membership year outcomes findingssix trajectory groups identified bayesian information criterion bic one five classified decrease heroin use probability using remaining high years probability use year one six classified demonstrating rapid decrease maintained abstinence probability heroin use among group declined steeply first years continued low remaining trajectories represented fluctuating patterns use baseline variables found predict trajectory group membership group membership predictive demographic substance use physical mental health outcomes years conclusionslong term trajectories heroin use australia appear show considerable heterogeneity decade follow risk factors predicting group membership fifth continued use high levels fewer fifth become abstinent early remained abstinent remainder showed fluctuating patterns
multi material arbitrary lagrangian eulerian mmale method effective way simulate multi material flow severe surface deformation comparing traditional arbitrary lagrangian eulerian ale method mmale method allows multiple materials single cell overcomes difficulties grid refinement process recent decades many researches conducted lagrangian rezoning surface reconstruction phases less attention paid multi material remapping phase especially three dimensional problems due two complex geometric problems polyhedron subdivision polyhedron intersection paper propose clipping projecting algorithm polyhedron intersection whose basic idea comes commonly used method grandy jia new algorithm solves geometric problem incremental modification topology based segment plane intersections comparison jia shows new method improves efficiency calculating polyhedron intersections moreover instability caused geometric degeneracy thoroughly avoided geometry integrity preserved new algorithm also focus polyhedron subdivision process describe algorithm could automatically precisely tackle various situations including convex non convex multiple subdivisions numerical studies indicate using polyhedron subdivision intersection algorithm volume conversation remapping phase exactly preserved mmale simulation elsevier inc rights reserved
insect like tailless flapping wing micro air vehicle mav without feedback control eventually becomes unstable takeoff flying insect like tailless mav challenging flying bird like tailed mav due difference control principles work introduces design controlled flight insect like tailless mav named kubeetle combination four bar linkage pulley string mechanisms used develop lightweight flapping mechanism could achieve high flapping amplitude approximately degrees clap flings dorsal ventral stroke reversals implemented enhance vertical force absence control surface tail adjustment location trailing edges wing roots modulate rotational angle wings used generate control moments attitude control measurements axis load cell showed control mechanism produced reasonable pitch roll yaw moments according corresponding control inputs control mechanism integrated three sub micro servos realize pitch roll yaw controls simple feedback controller implemented flight stability onboard microcontroller gyroscope sensed pitch roll yaw rates several flight tests demonstrated tailless kubeetle could successfully perform vertical climb hover loiter within ground radius small variations pitch roll body angles
many simulation models prohibitively expensive physically infeasible obtain complete set experimental data calibrate model parameters cases one alternatively employ validated higher fidelity codes generate simulated data used calibrate lower fidelity code paper employ information theoretic framework determine reduction parameter uncertainty obtained evaluating high fidelity code specific set design conditions conditions chosen sequentially based amount information contribute low fidelity model parameters goal employ bayesian experimental design techniques minimize number high fidelity code evaluations required accurately calibrate low fidelity model illustrate performance framework using heat diffusion examples kinetic neutron diffusion equation particle transport model include initial results integration high fidelity thermal hydraulics code hydra low fidelity exponential model friction correlation factor elsevier inc rights reserved
primary purpose article study impact distributed generator integrated distribution system terms electrical line losses reliability interruption cost single multi distributed generators study connected distribution system provincial electricity authority pea part thailand distribution system geographic information systems data including lengths distribution line load locations key parameters pea simulated using digital simulation electrical network calculation program digsilent addition capacity location installed distribution system considered system average interruption frequency index saifi system average interruption duration index saidi interruption cost assessed reliability indices comparing saifi saidi interruption cost base case without cases single multi dgs connected distribution system moreover electrical line loss considered terms active power line loss also compared base case results summarized focusing location capacity number size load distance load factors capable impacting electrical line loss saifi saidi interruption cost american institute chemical engineers environ prog
discontinuous galerkin methods allow high order flow solutions unstructured locally refined meshes increasing polynomial degree using curved instead straight sided elements however one currently largest obstacles applying methods aerodynamic configurations medium high complexity availability appropriate higher order curved meshes article describe complete chain higher order unstructured grid generation higherorder flow solution applied turbulent flow around three dimensional high lift configuration includes generation appropriately coarse straight sided mesh evaluation additional points computer aided design geometry curved wall boundary defining piecewise polynomial boundary representation iii higher order mesh deformation translate curvature wall boundary interior computational domain description discretization sufficiently stable allow flow computation resulting curved mesh finally fourth order flow solution reynolds averaged navier stokes turbulence model equations computed fourth order unstructured hybrid mesh around three dimensional high lift simulation wing flow noise generation configuration copyright john wiley sons ltd
trolley problem runs course consequentialists tend adopt one two strategies silently take comfort fact deontological rivals face enduring difficulties appeal cognitive psychology discredit deontological intuitions trolley problem depends refer first strategy silent schadenfreude second debunking attack aim paper argue consequentialists ought reject strategies instead opt call robust advantage strategy emphasizes intricate calculations consequentialists employ defend objections based friendship integrity argue calculations offer consequentialism explanatory advantage deontology context trolley problem requires striking delicate balance deeply internalized dispositions avoid causing harm context sensitive ability prevent disasters however empirical data help consequentialism front illustrating integration separate cognitive functions ordinary part human psychology
study examined whether differences habitual use mindfulness skills associated specific well neuroticism aspects two hundred eleven volunteers aged years completed measures mindfulness neuroticism psychological well pwb subjective well swb describing observing acting awareness mindfulness skills positively correlated personal growth purpose life autonomy core eudaimonic components pwb nonreactivity nonjudging mindfulness skills negatively associated neuroticism aspects withdrawal depression volatility anger describing nonreactivity mindfulness skills significantly correlated swb measures acting awareness mediated effect withdrawal volatility eudaimonic well outcomes describing consistent mediation effects across well measures withdrawal aspect nonreactivity nonjudging mediated withdrawal considering eudaimonic well outcomes mediation effects nonjudging nonreactivity found volatility swb markers well volatility self acceptance environmental mastery positive relations others eudaimonic pwb components sum mindfulness skills important eudaimonic well especially internalizing individuals authors discuss usefulness facet level analysis mindfulness examining incremental validity facets others accounting different well outcomes measures clinical implications also discussed
headache attributable disorders homeostasis represents diverse diagnostic category external high altitude internal fasting demands exceed homeostatic capacity resulting symptomatic headaches metabolic headaches especially fasting headache observed common general population many cases history migraine risk factor consistent hypothesis adaptive evolutionary role headache warn environmental physiological threats many exposures may also interpreted migraine triggers authors considered certain disorders category accurately represent primary headache disorders nonetheless disorders represent important clinical entities recognition may prevent medical morbidity also interesting exposure response models understanding regarding headache pathophysiology
authentication schemes widely deployed access control mobility management various communication networks especially schemes based multifactor authentication password smart card come practical one standard authentication schemes widely used secure communication internet session initiation protocol sip original authentication scheme proposed sip vulnerable crucial security weaknesses overcome security problems various improved authentication schemes developed especially based elliptic curve cryptography ecc recently zhang proposed improved authentication scheme sip based ecc using smart cards overcome security flaws related protocols zhang claimed protocol secure known security attacks however paper indicates zhang protocol still insecure impersonation attack show active attacker easily masquerade legal server fool users remedy also improve zhang protocol imposing little extra computation cost copyright john wiley sons ltd
non hodgkin lymphoma parotid gland relatively rare occurrence among head neck tumors mass parotid gland lymphoma distinguished benign masses parotid gland therefore important consider lymphoma differential diagnosis examining parotid swellings masses parotid gland lymphoma likely cell non hodgkin lymphoma one three types include follicular marginal zone diffuse large cell although histologic patterns described present review patient diffuse large cell lymphoma dlbcl presented department oral maxillofacial surgery pusan national university hospital yangsan korea
bulk viscosity zeta hadronic medium estimated within ambit hadron resonance gas hrg model including hagedorn density states hrg thermodynamics within grand canonical ensemble provides mean hadron number well fluctuation fluctuation chemical composition hadronic medium grand canonical ensemble result non zero divergence hadronic fluid flow velocity allowing estimate zeta hadronic matter relaxation time study influence hadronic spectrum zeta find correlation conformal symmetry breaking measure element estimate zeta along contours constant total entropy net baryon number plane temperature baryonic chemical potential also assess value zeta chemical freeze curve various centers mass energy root find bulk viscosity entropy density ratio zeta larger energy range beam energy scan program rhic low energy sps run ags nica fair lhc energies
years advice postpone introducing allergenic foods order prevent food allergies however food allergies escalated rather declined review latest epidemiological immunological nutritional research suggests early weaning practices may beneficial allergenic foods fish eggs peanuts proved inherently rich tolerogenic substances play significant role preventing allergies conclusion found evidence immunoregulatory anti inflammatory properties allergenic foods provoke oral tolerance introduced early low risk high risk infants
purpose describe factors associated rtw patients years stroke methods cross sectional study including patients years hospitalization first ever stroke years gainfully employed stroke patients completed set questionnaires working status educational level physical functioning frenchay activities index fai mental functioning hospital anxiety depression scale hads coping orientations problems experienced cope easy quality life short form euroqol caregivers completed caregiver strain index csi baseline stroke characteristics gathered retrospectively baseline characteristics current health status compared patients rtw means logistic regression analysis odds ratios confidence intervals adjusted age gender results forty six patients included mean age years mean time since stroke months rtw adjusting age gender shorter length hospitalization associated rtw current health status lower hads depression score less avoidant coping style better scores fai mental component summary score eqd csi associated chance rtw conclusions minority working patients rtw stroke shorter duration initial hospitalization associated favorable work outcome significant association work status activities mental aspects quality life underlines need develop effective interventions supporting rtw
online bookstores highly thrived changed consumer behaviors years however customers online bookstores specific targets one reason current web interfaces usually complex cluttered users browse addition current visualization interfaces display results associated single attribute thus requiring users interact intensively find targets inspired user experiences physical bookstores present bookwall online bookstore interface comprises two components category map wall view enabling users find targets efficiently releasing users burden complicated operations specifically category map produces map natural map like look providing overview clusters neighborhood book categories wall view enables displaying query results satisfying dual query attributes simultaneously results show bookwall provide users favourable alternative visualization
monte carlo method used quantitative structure activity relationship modeling bis quinolinium bis isoquinolinium compounds acetylcholine esterase inhibitors series compounds quantitative structure activity relationship models calculated representation molecular structure simplified molecular input line entry system one split training test set examined statistical quality developed model good best calculated quantitative structure activity relationship model following statistical parameters training set test set structural indicators defined molecular fragments responsible increases decreases inhibition activity calculated computer aided design new compounds potential acetylcholine esterase inhibitors application defined structural alerts presented
premature infant needs stable thermal environment paper studies infant weight employed standard heat regulation system incubators done two stages first weight sensor designed means using strain gauge order provide weight measurement later heat regulation circuit designed implemented means using microcontroller humidity environmental skin temperature infant weight measured used inputs experiments showed infant weight successfully added control circuit incubator instrument results showed infant weight productively contribute temperature control good confidence average standard error equal degrees results reveal infant weight contribute increase quality assurance incubators
fiber rein forced composite materials outstanding mechanical electrical properties applications expanded commercial products well military components using composite materials researchers studied radar absorbing stealth technology research develop radar absorbing structure ras hybrid composite materials fabricated three dimensional shape shells series experiments analysis conducted characterize ras shells hybrid composite consists absorbing layers made three phase composite glass fiber epoxy earbon black reflection layers made carbon fiber reinforced epoxy manufacture spring back free composite shells aluminum molds additional bending angles used cure process composite finally evaluate radar absorbing efficiency ras radar cross section rcs measured compact range method hybrid ras shows average radar absorption efficiency
objective identify knowledge attitudes towards emergency contraception women five european countries methods internet based survey sexually active women aged years france germany italy spain asked use opinions results overall women completed survey thirty percent reported unprotected sexual intercourse previous months population risk twenty four percent population risk reported using common reasons given using perceiving risk pregnancy thinking option third respondents indicated know works several misconceptions noted leading infertility similar abortion seventy nine percent women agreed responsible choice prevent unwanted pregnancy nearly third women used felt uncomfortable judged obtaining conclusions underutilised three quarters women surveyed women recognise may risk pregnancy contraception fails still several misbeliefs indicating need better education public
electric vehicles evs become popular abundance valuable engineering resources dedicated creating full scale test beds validate modify vehicle hardware software paper presents systematic approach scaling full size electric vehicles parameters environmental conditions level handled small scale hardware loop hil simulation test bed paper also presents method scaling simulation results back full size vehicle level test bed realized using two electric machine system one machine represents vehicle traction motor emulates vehicle parameters operating environment
endogenous testosterone aging man scrutinized extensively regard effects performance many cognitive domains especially verbal fluency visuospatial visuoperceptual abilities memory executive function studies testosterone supplementation sought identify potential cognitive improvements men without baseline cognitive impairment wide range results variability outcomes likely related part lack consensus methods testosterone measurement supplementation part disparate measures cognitive function used randomized controlled studies despite limitations imposed inconsistent methods promising associations found cognition testosterone supplementation eugonadal men men low testosterone levels without baseline cognitive dysfunction systematic review highlights cognitive measures used outcomes existing studies testosterone cognition aging men review suggests larger studies standardized approach assessment needed fully understand realize sustained benefits testosterone supplementation elderly male population particularly given substantial increase testosterone supplementation clinical practice
objective study assess patient preferences treatment related benefits risk disease relapse management low disease states psoriatic arthritis psa focus groups patients literature review undertaken determine characteristics treatment symptoms psa important patients patient preferences assessed using discrete choice experiment compared hypothetical treatment profiles risk benefits treatment withdrawal risk outcome included increased risk disease relapse benefit outcomes included reduced sickness nausea medication changes health related quality life patient completed choice sets comparing treatment profiles preference weights estimated using logic regression model maximum acceptable risk disease relapse given improvement benefit outcomes elicited final sample included patients respondents attached greatest importance eliminating severe side effects sickness nausea least importance change risk relapse respondents willing accept increase risk relapse order eliminate side effects sickness nausea improvements health status maximum acceptable risk relapse comparable movement sickness nausea study suggests patients low disease states psa willing accept greater risks relapse improvements side effects sickness nausea overall health status important benefit attribute elimination severe sickness nausea
since marked increase number reports severe often fatal fungal skin infections wild snakes eastern usa emerging condition referred snake fungal disease sfd initially documented rattlesnakes infections believed pose risk viability affected populations disease caused ophidiomyces ophiodiicola fungus recently split complex fungi long referred chrysosporium anamorph nannizziopsis vriesii canv review current state knowledge ophiodiicola sfd addition provide original findings demonstrate ophiodiicola widely distributed eastern north america broad host range predominant cause fungal skin infections wild snakes often causes mild infections snakes emerging hibernation new information together already available scientific literature advances knowledge cause pathogenesis ecology sfd however additional research necessary elucidate factors driving emergence disease develop strategies mitigate impacts article part themed issue tackling emerging fungal threats animal health food security ecosystem resilience
introduction psoriasis chronic immune mediated skin disorder associated significant physical psychological quality life impairments along well documented genetic environmental factors immunological factors also contribute pathogenesis psoriasis among immunological factors dependent cell proliferation form cells play major role pathogenesis psoriasis itolizumab first humanized igg monoclonal antibody selectively targets areas covered current article presents pharmacology itolizumab provides review currently available data efficacy safety itolizumab management moderate severe plaque psoriasis expert opinion use biologics attenuate immune mediated pathological events psoriasis relatively well established clinical practice however safety efficacy biologics continues unsettled topic ongoing research available data seems suggest itolizumab may safer option additional studies higher sample sizes active comparators needed definitive conclusions drawn place itolizumab management psoriasis
sometimes automatic evaluations correspond well reflect articulate present novel approach assessment automatic reflective affective evaluations exercising based assumptions associative propositional processes evaluation model measured participants automatic evaluations exercise shared information asked reflect rate eventual discrepancy reflective evaluation assessment automatic evaluation found mismatch self reported ideal exercise frequency actual exercise frequency previous weeks could regressed discrepancy relatively negative automatic positive reflective evaluation study illustrates potential dual process approach measurement evaluative responses suggests mistrusting one negative spontaneous reaction exercise asserting positive reflective evaluation instead leads adoption inflated exercise goals
marangoni convection volatile liquid film subject horizontal temperature gradient confined rectangular cavity basic problem heat transfer fluid mechanics applications evaporative cooling marangoni stresses drive flow due surface tension gradients liquid vapor interface thermocapillary stresses due variations surface tension temperature part drive liquid away hot regions volatile binary fluid mixture however designed solutocapillary stresses due variations surface tension concentration drive liquid instead towards hot regions hence oppose thermocapillary stresses thicker liquid layers flow also affected buoyancy work details experimental study buoyancy marangoni convection similar deep layer methanol water meoh sealed rectangular cuvette driven temperature difference similar degrees horizontal distance particle pathline visualizations particle image velocimetry piv used study flow determine liquid composition quantified terms meoh concentration noncondensables air quantified concentration air gas space liquid affect flow solutocapillary effects strong enough drive liquid near free surface towards heated end entire horizontal extent liquid layer low suggesting binary fluid coolants could significantly reduce film dryout flow driven thermocapillarity solutocapillarity buoyancy classified four distinct flow regimes summarized flow regime map elsevier ltd rights reserved
purpose overactive bladder oab patients systemic diseases dry mouth tends prominent owing effects systemic diseases related medications evaluated systemic diseases affect dry mouth anticholinergic treatment materials methods oab patients enrolled study patients divided according presence absence systemic diseases patients systemic diseases sub grouped number systemic diseases one one disease oab symptoms score oabss visual analogue scale vas score dry mouth body mass index bmi measured statistical assessments done independent tests ancovas results one hundred four oab patients enrolled study seventy patients systemic diseases thirty four patients age bmi higher systemic diseases group baseline vas score oab systemic diseases group higher oab without systemic diseases group even age bmi adjustment difference significant follow vas score also different change vas score different sub analysis change vas score group two systemic diseases higher group one systemic disease conclusion severity xerostomia treatment anticholinergics oab increases patients one systemic disease parallel severity starting treatment however patients two systemic disease magnitude change xedrostomia score higher would expect patients one systemic diasese
scope study microstructure macroproperty relationship cement mortars established order define effects microstructural phases strength microstructural studies become great issue materials engineering nowadays characterize microstructural phase properties improve modify performed scientist forecasting enhancing according objective cement mortars incorporating chemical admixtures prepared constitute different microstructural graphs micrographs analyzed determine amounts unhydrated cement part undifferentiated hydrated part capillary pore phases cement mortar sections afterwards amounts microstructural phases related strength values cement mortar specimen relationship established using generalized regression neural network analysis elsevier ltd rights reserved
numerous long span bridges built throughout world recent years desirable challenging detect local abnormalities long span bridge early stage stress influence lines sil derivatives recognized promising indices damage detection paper explores novel damage localization approach synthesizing sil measurements multiple locations dempster shafer data fusion technique utilized compared measurement single sensor reliable damage related information improved sensitivity capability damage localization obtained synthesizing measured sils number sensors effectiveness proposed method validated numerical case study tsing suspension bridge different hypothetical scenarios including single damage case double damage damage cases considered validation comparison damage detection results using single sensor data clearly indicates data fusion technique effectively enhance consistency information damage induced structural change minimize non consistent information noise effect multiple sensors installed close damage increasing number sensors benefits damage detection results excellent damage detection accuracy achieved different types bridge components properly selected monitoring therefore promising use proposed approach study damage localization real world long span bridges parametric studies conducted examine effects parameter selections noise levels approach
pathogenesis tauopathies involves accumulation tau brain progressive synapse loss accompanied cognitive decline pathological tau found synapses promotes synaptic dysfunction memory deficits specific role toxic tau disrupting molecular networks regulate synaptic strength elusive novel mechanistic link tau toxicity synaptic plasticity involves acetylation two lysines tau associated dementia alzheimer disease propose increase tau acetylated lysines blocks expression long term potentiation hippocampal synapses leading impaired memory acetylated tau could inhibit activity dependent recruitment postsynaptic ampa type glutamate receptors required plasticity interfering postsynaptic localization kibra memoryassociated protein strategies reduce acetylation tau may lead effective treatments cognitive decline
cognitive bias questionnaire psychosis cbqp valid selfreport instrument assessing cognitive biases psychosis validate japanese version cbqp investigate relationships cbqp various schizophrenia symptoms positive symptoms negative symptoms disorganized autistic preoccupation patients schizophrenia patients depression healthy controls recruited using samples psychometric properties japanese version cbqp tested cbqp total scores good reliability two subscales moderate reliability furthermore scales adequate concurrent validity given significant correlations positive symptoms could accurately distinguish schizophrenia patients healthy controls novel findings cbqp total scores positively correlated disorganized autistic preoccupation furthermore study using japanese sample showed marginally significant correlations cognitive biases threating event severity delusions relationship seen previous study used western sample difference could shame culture explained characteristic japanese japanese version cbqp reliable valid original
background prenatal inflammatory mechanisms may play role pathogenesis psychiatric disorders could relevant attention deficit hyperactivity disorder adhd investigated maternal chronic somatic diseases immune components possible risk factors adhd offspring methods performed population based nested case control study linking data longitudinal norwegian registers included individuals born period alive record linkage individuals receiving adhd medication years defined patients adhd remaining individuals defined control subjects associations maternal diseases adhd offspring analyzed using logistic regression models results following chronic diseases immune components related adhd offspring multiple sclerosis adjusted odds ratio confidence interval rheumatoid arthritis adjusted type diabetes adjusted asthma adjusted hypothyroidism adjusted contrast chronic hypertension type diabetes showed significant associations estimates almost unchanged additional adjustment parental adhd infant birth weight gestational age although point estimates male female offspring different diseases maternal asthma adjusted female offspring adjusted male offspring none associations differed significantly offspring sex conclusions several maternal somatic diseases immune components found increase risk adhd offspring associations could involve several causal pathways including common genetic predisposition environmental factors increased insight mechanisms behind relationships could enhance understanding etiology adhd
individuals history child abuse high risk depression anxiety disorders aggressive behavior substance use problems goal paper review studies genetics stress related psychiatric disorders informative subset studies examined candidate gene environment gxe predictors psychiatric problems individuals maltreated children reviewed together extant genome wide association studies gwas emerging findings epigenetic changes associated adverse early experiences also reviewed meta analytic support replicated findings evident several genetic risk factors however extant research suggests effects pleiotropic genetic factors associated distinct psychiatric disorders rather diverse clinical phenotypes research also suggests adverse early life experiences associated changes gene expression multiple known candidate genes genes involved dna transcription translation genes necessary brain circuitry development changes gene expression reported key brain structures implicated pathophysiology psychiatric substance use disorders finding pleiotropy highlights value using research domain criteria rdoc framework future studies genetics stress related psychiatric disorders trying simply link genes multifaceted clinical syndromes limited phenotypes map onto distinct neural circuits emerging work field epigenetics also suggests translational studies integrate numerous unbiased genome wide approaches help unravel genetics stress related psychiatric disorders wiley periodicals inc
article proposes multi period optimization study technical economic effects placement use renewable energy sources res energy storage systems ess electrical network res penetrations increase inherent variability affects actual amounts energy dispatched contribution decrease emissions pollutants greenhouse gases overall welfare effects may moreover better harness energy renewable sources new methodologies technologies need adopted counteracting variability uncertainty sources possible solution challenges res adoption coupling energy storage sources either dedicated facilities supply side supporting accommodation loads available generation demand side paper suggests algorithm network dispatch aimed answering fundamental changes way system managed discusses analytical characteristics optimal solution proposed methodology applied case study four scenarios analyzed dispatches estimating welfare effects participants wholesale market modified ieee bus network wind energy res penetrations close policy implications results obtained prove first ess decrease ramping necessary load following necessarily increase amount wind energy used second congestion patterns electrical network play crucial role final effectiveness res ess important insights ongoing debate direct storage renewable energy investments low carbon economy elsevier ltd rights reserved
research policy observers increasingly concerned potential impact current academic working conditions mental health particularly phd students aim current study threefold first assess prevalence mental health problems representative sample phd students flanders belgium second compare phd students three samples highly educated general population highly educated employees higher education students third assess organizational factors relating role phd students predict mental health status results based mental health symptoms ghq showed phd students risk developing common psychiatric disorder especially depression estimate significantly higher obtained comparison groups organizational policies significantly associated prevalence mental health problems especially work family interface job demands job control supervisor leadership style team decision making culture perception career outside academia linked mental health problems elsevier rights reserved
paper smart classroom system enables lecturer monitor current level interest audience presented system based adaboost machine learning algorithm using training dataset collected lectures system implemented matlab capable recognizing patterns sound spectral entropy formant frequency images descriptors students motion axis accelerometer lecturers motion descriptors system performance evaluated fold cross validation total average accuracy simulation simulation system implemented performance evaluated comparing real time annotator students feedback system output live lectures average accuracy system evaluated three different groups students indicating still room improvement basis novel approach detecting level interest lecture creates classroom environment
gravure printing one promising technologies high volume production printed electronics microscale films devices characteristics printed pattern ink volume resolution pattern placement registration directly related fluid mechanics liquid transfer process cell substrate wrapped around rotating roll liquid transfer mainly controlled free surfaces dynamic contact lines available analyses restricted axisymmetric flows relative motion cavity substrate greatly simplified recent results shown use complete description relative motion roll roll process critical obtain accurate results amount liquid transferred substrate work present extension model describing liquid transfer groove substrate process order consider liquid transfer small individual cell end solve full free surface flow moving contact lines results show liquid transfer dynamics governed two different characteristic time scales one associated contact line motion liquid filament breakup dependent capillary number predictions show volume registration shape printed dot varies operating conditions liquid properties predictions could helpful designing high precision printing operations elsevier ltd rights reserved
background although domestic hiv aids financing increasing international hiv aids financing plateaued providing incentives health system performance based financing pbf may help countries achieve available resources systematically reviewed effects pbf hiv aids service delivery inform guidelines methods pubmed index medicus conference databases clinical trial registries searched april randomised trials comparative contemporaneous studies time series studies studies evaluating pbf people hiv included reported service quality access cost meta analyses possible due limited data study registered prospero number crd results four studies published including people met eligibility criteria studies sub saharan africa pbf improve individual testing coverage relative risk confidence interval improved couples testing coverage improved pregnant women testing coverage pbf improved coverage antiretrovirals pregnant women infants adults pbf reduced attrition treatment failure odds ratio potential harms reported conclusions although limited data suggests pbf positively affected hiv service access quality critical health system governance knowledge gaps remain research needed inform national policymaking
objective late onset hypogonadism androgen deficiency aging male significant cause morbidity older men many men low normal equivocal range low testosterone level exhibit signs symptoms hypogonadism serum testosterone imperfect maker hypogonadism symptoms vary greatly within low low normal range addition variations among testosterone assays perineal ultrasound effectively used examine bulbocavernosus muscle bcm androgenized tissue may impacted androgen receptor activity methods study retrospective analysis men underwent perineal ultrasound hypogonadism ultrasound data used calculate area bcm correlate indices hypogonadismin symptomatic men including free total testosterone dual energy ray absorptiometry dexa results results demonstrate significant correlation total free testosterone bcm area hypogonadal patients comparison bcm area total testosterone showed comparison bcm area free testosterone showed addition low bcm also correlated dexa results showing osteoporosis osteopenia conclusion recent controversy safety testosterone replacement therapy might particularly important men hypogonadal symptoms low normal testosterone level study investigated use perineal ultrasound measure bcm surrogate marker poor androgenized men presenting hypogonadism editorial office asian journal urology production hosting elsevier
background long non coding rnas lncrnas emerged key players remarkably variety biological processes pathologic conditions including cancer next generation sequencing technologies bioinformatics procedures predict existence tens thousands lncrnas know functions handful little known cancer types head neck squamous cell carcinomas hnsccs results use rnaseq expression data cancer genome atlas tcga various statistic software tools order get insight lncrnome hnscc based lncrna expression across samples discover five distinct tumor clusters compare reported clusters based various genomic genetic features results demonstrate significant associations lncrna based clustering dna methylation mutation human papillomavirus infection using guilt association procedures infer possible biological functions representative lncrnas cluster furthermore found lncrna clustering correlated important clinical pathologic features including patient survival treatment tumor grade sub anatomical location conclusions present landscape lncrnas hnscc provide associations important genotypic phenotypic features may help understand disease
collapse drinking water management systems one serious consequences natural disasters article aims analyze vulnerability drinking water management natural disaster rural coastal areas bangladesh considered extreme event cyclone aila devastated coastal district satkhira study area collection drinking water normal situations difficult mainly spatially varied availability drinking water sources tube wells ponds rainwater harvesting units addition decreasing trend pre monsoon rainfall intensity well increased salinity play significant role regard due destruction coastal embankment cyclone aila saltwater intruded locality heavily damaged drinking water sources analyze associated vulnerability factors drinking water sector conducted household based structured questionnaire survey three mouza revenue collection unit satkhira district using principal component analysis identified six factors influencing drinking water vulnerability factors related warning dissemination damage water sources damage household water reserves collection time family composition frequency water collection used factors prepare index comparative analysis vulnerability among three mouza considering vulnerability issues article concludes presenting scope robust drinking water management plan coastal areas bangladesh elsevier ltd rights reserved
software product lines spl aim reducing time market increasing software quality extensive planned reuse artifacts essential activity spl variability management defining managing commonality variability among member products due large scale complexity today software intensive systems variability management become increasingly complex conduct accordingly tool support variability management gathering increasing momentum last years considered key success factor developing maintaining spls several studies already conducted variability management none analyzed available tool support detail work report survey analyzed existing variability management tools identified using systematic literature review understand tools characteristics maturity challenges field conclude studies variability management tools provide good motivation description research context challenges often lack empirical data support claims findings also found quality attributes important practical use tools usability integration scalability performance scope studies
recent years gis increasingly used fundamental survey data management tool multi disciplinary fields gis originally designed environmental use territorial management today frequently used analysis cataloguing modelling sites considered cultural archaeological architectural importance software may used manage territory whole must necessarily applied even case surveying graphic rendering management relational databases aspects characterize cultural heritage case related innovative application field currently developed enormous potential field research study archaeological area tyre tends define guidelines produce application methodology management spatial data archaeological elements views generally occurs also elevation drawings perspective representations completely ignored gis graphic elements processed exclusively cad aim research project produce complete detailed dynamic map archaeological site may represented realistically three dimensions fully exploiting interrogation potential vectorial data sql language gis surveys archaeological structures performed advanced tools laser scanner case processed gis permitting depth analysis geometry respect detailed information recorded catalogued rdbms georeferencing allocate correct geographic information data project developed tyre lebanon site takes account archaeological area whole focusing particular triumphal arch autocad vectorial map reprocessed full starting project arcmap specific shapefile created database connected structured allocating elevation details make possible create features may imported arcscene processing software esri polylines transformed polygons permit areal processing analysis single elements arch assembling descriptive data element table correct georeferencing allocated system may used internationally namely utm wgs case zone ensure correct positioning even real potential research method possible analyze vectorial elements perspective views taking account correct geographic location implementations offered gis intelligence rather simply working reconstructions views models
growing recognition winter important season growth photoautotrophs ice covered freshwater environments exemplifying expansive ice blooms filamentous diatoms lake erie describe metatranscriptome constructed phytoplankton community dominated filamentous diatoms expected high percentage sequences blast hits nucleotides proteins national center biotechnology information databases associated photosynthetic algae majority diatoms mainly aulacoseira spp stephanodiscus spp confirmed analysis rrna gene transcripts microscopy consistent winter growth environment psychrophilic low light adaptations observed prominent among adaptations cold transcripts genes involved biosynthesis unsaturated fatty acids consistent expected increased membrane fluidity low temperatures reflecting combined effect low winter insolation high light attenuation abundant complement reads light harvesting antennae mainly genes encoding fucoxanthin chlorophyll proteins presence virulence factors originating oomycetes offers support new hypotheses eventual decline lake erie winter diatom bloom whereas fungi identified metatranscriptome microscopy dsrna viruses fungi detected may indirectly counter fungal infection study demonstrates utility environmental omics approach yield insights underlying phototrophic life well interactions entire microbial community extreme environment international association great lakes research published elsevier rights reserved
background randomized controlled studies reported effect catheter ablation atrial fibrillation follow months objective report effect plus antiarrhythmic drugs comparison antiarrhythmic drugs alone maintenance sinus rhythm year follow methods extended follow duration patients enrolled catheter ablation cure atrial fibrillation study february june randomized antiarrhythmic drugs control group antiarrhythmic drugs plus ablation group primary end point time first symptomatic asymptomatic recurrence atrial arrhythmia lasting seconds follow results follow confidence interval ablation group patients control group patients experience relapse atrial tachyarrhythmia kaplan meier analysis performed determine probability survival free atrial arrhythmias showed statistical difference favor ablation group log rank effect consistent patients paroxysmal persistent multivariate cox regression analysis belonging control group hazard ratio longer time since first episode hazard ratio predictors atrial tachyarrhythmia recurrence conclusion patients paroxysmal persistent significantly increased time first recurrence atrial arrhythmias year follow
recent years become apparent schema matching labor intensive process costly resources led development various automated tools substitute human experts involved end propose two new ideas first separation matching techniques strong weak ones call two phase schema matching second using information human expert provide system process schema matching used determine combine various matching techniques system encompassing ideas easily tunable allows human expert become part matching process help system choose best techniques use extensive experiments demonstrate approach better contemporary state art systems relational databases also demonstrate single purpose niche matchers helpful system system opt use appropriate
achieve influence underwater windmill flow parameters structure parameters related changes hydrodynamic characteristics underwater windmill additional contraction device devised according orthogonal experimental design flow velocity shrinking angle locating range outlet diameter selected four factors carry orthogonal experiment paper results numerical simulation show influences output torque axial force hydrodynamic performance underwater windmill flow velocity locating range outlet diameter shrinking angle turns influence flow velocity locating range output torque axial force underwater windmill evident shrinking angle small influence output torque increases inhomogeneity hydrofoils surface pressure distribution much evidence obvious flow separation phenomenon occurred hydrofoils surface indicates hydrofoil design reasonable extent upper edge hydrofoil pressure value much lower namely position may exist cavitations region increase radius cavitation region moves trailing edge gradually mechanics analysis results also show assumption rigidity hydrofoil reasonable process numerical simulation research conclusions provide significative reference hydrodynamic performance research underwater windmill
sought validate extend findings psoriatic arthritis patient cohort dublin using patient cohort bath central finding study several structurally unrelated hla alleles including found significantly associated particular phenotypic features psoriatic arthritis implying clinical diagnosis psoriatic arthritis designates genetically heterogeneous subset individuals radiographic sacroiliitis associated either implications role mhc molecules adaptive immune response also implications psoriatic arthritis diagnostic criteria since disease features used criteria genetic control findings important implications understanding role mhc alleles directing adaptive immune response mediate inflammation responsible psoriatic arthritis elsevier inc rights reserved
prosocial behaviors susceptible individuals preferences regarding payoffs social context present study combined individual differences social influence attempted discover effect social value orientation svo social influence prosocial behavior trust game dictator game prosocial behavior trust game could motivated strategic considerations whereas individuals decisions dictator game could associated social preference trust game prosocials less likely proselfs conform behavior group members majority group members distrusted trustee dictator game results three way anova indicated irrespective type offer contrast proselfs prosocials influenced others generous choices selfish choices even selfish choices beneficial overall results demonstrated effect social influence appears depend individuals svo prosocials tend conform prosocial rather proself behaviors
mobile robot networks emerged past years promising distributed computing model existing work literature typically ensures correctness mobile robot protocols via hoc handwritten proofs case asynchronous execution models cumbersome error prone contribution twofold first propose formal model describe mobile robot protocols operating discrete space finite set possible robot positions synchrony asynchrony assumptions translate formal model dve language input format model checkers divine tools formally prove equivalence two models verify several instances two existing protocols variants ring exploration asynchronous setting exploration stop perpetual exclusive exploration first protocol refine correctness bounds second one exhibit counter example protocol modified establish correctness new version inductive proof
aim reported great proportion mental health disorders origin early childhood order evaluate factors possibly associated children health health monitoring units established since six study regions bavaria germany second health monitoring survey implemented focuses mental health status preschool children goal study examine association sociodemographic environmental factors mental health analyze applicability results health monitoring units preschool children bavaria calculating weighting factors methods data preschool children available logistic regression analysis applied analyze possible associations mental health weighting method applied correct deviances compared whole population preschool children bavaria results preschool children show mental health problems regarding different indicators sociodemographic status low household income unadjusted shows strongest association mental health problems non accessibility green space unadjusted also strongly associated mental health results unweighted weighted analysis similar conclusion findings suggest sociodemographic status factors living environment show associations mental health children based results unweighted weighted analyses second health monitoring analysis shows little deviances compared data bavarian preschool children therefore results compared bavarian preschool children elsevier gmbh rights reserved
immigration global phenomenon yet comparatively psychological investigations anti immigrant prejudice conducted east asia region high economic growth set become leading destination international migrants two studies examined singaporean attitudes towards four prominent immigrant groups chinese filipino south asian western immigrants immigrant group found associated unique attitudinal profile chinese immigrants culturally closely related singaporeans viewed negatively terms prejudice stereotyped warmth realistic symbolic threat westerners viewed positively despite higher ratings perceived competence possibly due western cultural influence whereas south asians filipinos viewed relatively unthreatening possibly due occupation undesirable social roles perceived threat realistic symbolic proved stronger predictors anti immigrant prejudice stereotypes implications immigration policy region discussed
background previous studies suggest prevalence wheat gluten sensitivity adherence gluten free diet gfd high latin population despite poor diagnosis celiac disease however prevalence rates still remain unknown latin american countries methods cross sectional survey study conducted santa argentina results estimated self reported prevalence rates confidence interval self reported gluten sensitivity currently following gfd celiac disease wheat allergy self reported non celiac gluten sensitivity ncgs ncgs currently following gfd adherence gfd common women associated irritable bowel syndrome among gfd followers reasons health related benefits without medical dietitian advice non group main motivations following gfd weight control perception gfd healthier conclusion argentina gluten sensitivity commonly reported seems physicians gastroenterologists aware celiac disease diagnosis trustable information benefits potential consequences following gfd given general population
purpose study conducted evaluate changes liver stiffness volume function occlusion spontaneous portosystemic shunt materials methods twenty four patients men women mean age years age range years underwent percutaneous occlusion spontaneous portosystemic shunt gastric varices hepatic encephalopathy march june liver fibrosis index indicating liver stiffness calculated using ultrasound elastography shunt occlusion liver volume liver profile also evaluated results spontaneous portosystemic shunt occlusion uneventfully performed patients mean liver fibrosis index significantly decreased shunt occlusion month months months afterwards significant increase liver volume observed shunt occlusion month months afterwards significant improvement child pugh score also found month months months shunt occlusion compared conclusion liver stiffness decreases along increase liver volume improvement liver function spontaneous portosystemic shunt occlusion editions francaises radiologie published elsevier masson sas rights reserved
purpose examine effects smoking cessation campaign design data taiwan adult tobacco surveys analyzed setting study set among nationally representative sample adults taiwan subjects surveys included adults respectively analyses focused current smokers adults respectively intervention taiwanese government launched national smoking cessation campaign mass media conjunction community based smoking cessation programs throughout nation measures outcome variables include awareness cessation services quit attempts intention quit use quitting method analysis multivariate logistic regressions used analyze data results implementation national smoking cessation campaign associated increase awareness cessation services odds ratio confidence interval quit attempts use unassisted quitting methods intention quit smoking conclusion implementation national smoking cessation campaign media community programs effective increasing smokers awareness cessation services quit attempts intention quit
eyewitness testimony considered reliable important ensure memory remains accurate following event many testimonies involve traumatic opposed neutral events important consider role distress susceptibility false memories aim study investigate whether cortisol response following stressor would associated susceptibility false memories psychological distress responses also investigated specifically dissociation intrusions avoidance participants allocated one three conditions viewed neutral film viewed real trauma film trauma reappraisal group participants told film real received misinformation film form narrative participants provided saliva samples assess cortisol completed distress memory questionnaires cortisol response significant predictor misinformation effect dissociation avoidance related confabulations conclusion following stressor individual may differ regard psychological response event also whether experience cortisol increase may affect whether distressed later also whether remember event accurately
current study sought address gender differences prosocial behavior creating validating multidimensional measure prosocial behavior fully captures ways men help others new measure directed toward family friend strangers five factors defending emotional support inclusion physical helping sharing study cfa analyses performed sample emerging adults online mean age revealed good model fit divergent validity five factors study replicated analyses sample urban adolescents northwest mean age results established factors good model fit construct validity convergent validity discussion focuses implications measure future prosocial research including increased diversity people particularly men help others developmental differences toward different targets prosocial behavior foundation professionals services adolescents published elsevier ltd rights reserved
computer graphics computer vision communities working closely together recent years variety algorithms applications developed analyze manipulate visual media around three major driving forces behind phenomenon availability big data internet created demand dealing ever increasing vast amount resources powerful processing tools deep neural networks provide effective ways learning deal heterogeneous visual data new data capture devices kinect bridge algorithms image understanding model analysis driving forces emerged recently believe computer graphics computer vision communities still beginning honeymoon phase work survey recent research computer vision techniques benefit computer graphics techniques vice versa cover research analysis manipulation synthesis interaction also discuss existing problems suggest possible research directions
today data reconstruction digital communication systems requires designs highest throughput rate low power viterbi algorithm key element digital signal processing applications nonlinear recursive nature viterbi decoder makes high speed implementation challenging several promising approaches achieve either high throughput low power proposed past combination developed paper additional new concepts allow building signal flow graph suitable design high speed viterbi decoders low power using flexible datapath generator facilitates essential quantitative optimization architectural physical level fully exploit low power high speed potential given technology parameterizable design entry datapath generator establishes basis scalable platform based design library altogether allows coverage range today industrial interest high throughput rates msymbols gsymbols using conventional cmos logic features two exemplary viterbi decoder implementations prove benefit physically oriented design methodology terms speed low power compared leading edge implementations
optimal power flow opf problem minimizes power loss electrical network optimizing voltage power delivered network buses nonconvex problem generally hard solve leveraging recent development zero duality gap opf propose second order cone programming convex relaxation resistive network opf study uniqueness optimal solution using differential topology especially poincare hopf index theorem characterize global uniqueness different network topologies line radial mesh networks serves starting point design distributed local algorithms global behaviors low complexity computationally fast run synchronous asynchronous settings practical power grids
design simulate nonsymmetric vernier type multiple ring resonator mrr filters achieve wider free spectral range fsr different ring radii expanded fsr determined least common multiple fsrs individual ring resonators dependence transmission characteristics mrr coupling coefficients directional couplers studied improvement suppression interstitial resonances using high order vernier filters also investigated graphical approach signal flow graph found useful quickly deriving optical transfer functions filters domain society photo optical instrumentation engineers
seeking product quality essential nowadays one many quality aspects software development source code complexity taking care complexity development result unexpected cost caused difficulty source code understanding goal paper introduce initial approach identify unnecessary complexity source code besides identifying also show user properly rewrite source code without unnecessary complexity approach based static analysis source code control flow graph unnecessary complexity identified graph refactored order allow user understand improvement source code implemented software tool order prove concept performance evaluation performed resulting high accuracy two experimental studies also performed assess feasibility used real users evidences provided studies suggests approach support unnecessary complexity removal
background distribution morbidity common psychiatric disorders largely explained manifestations two broad psychopathological spectra internalizing externalizing disorders twin studies suggest spectra arise genetic factors method structural equation twin modeling applied interview questionnaire data personality traits lifetime psychiatric disorders members male male female female twin pairs results best fitting models externalizing internalizing spectra differed significantly males females males externalizing genetic common factor best indexed four disorders following order antisocial personality disorder aspd drug abuse dependence dad alcohol abuse dependence aad conduct disorder females four disorders closely related externalizing common factor order dad aad nicotine dependence aspd personality traits novelty seeking extraversion better indexed genetic externalizing spectrum females males males females major depression generalized anxiety disorder gad best indexed genetic internalizing common factor panic disorder agoraphobia agp better reflected internalizing genetic common factor women neuroticism men genetic correlations two spectra estimated males females conclusions disorders optimally index genetic liability externalizing internalizing disorders general population differ meaningfully men women sexes genetic spectra better assessed psychiatric disorders personality traits
increasing requirements improved reliability electrical power devices optimisation dielectric insulation design means analysis impact due overvoltages high importance analysis also consider propagation overvoltages transferred power transformer windings parts electrical network hazard levels overvoltages affected insulation systems electrical devices determined wave propagation conditions overvoltages well protection level applied overvoltages protection analysis overvoltages transferred low voltage networks important due increasing number electrical devices electronic apparatus low resistance overvoltages study presents detailed analysis propagation overvoltages transferred distribution transformer windings typical medium low voltage electrical networks analysis based simulation results carried use electromagnetic transients program alternative transients program emtp atp high frequency model transformers done basis frequency characteristics admittance measurements used simulations detailed analysis influence length medium low voltage lines connected distribution transformers metal oxide surge arresters switching overvoltages transferred low voltage networks presented study
rapid development science technology computer network technology spread areas production life however network connectivity openness characteristics resulting network security problems prominent network data theft hacker attack viruses trojan attacks issues direct threat network information security economic social life even national security caused threat paper analysis computer network security risks existing information security threats facing explore appropriate protective strategy
aim study investigate serum leptin ghrelin levels relations circulating cortisol thyroid hormones lipids homocysteine hcy folic acid dogs compulsive tail chasing ctc material study consists fifteen dogs ctc healthy controls various weights breeds ages sexes enrolled study ctc diagnosed basis dog behavioral history clinical signs results medical assessments none dogs considered concurrent medical disease would account ctc dogs ctc higher leptin lower ghrelin levels healthy controls serum cortisol lipids cholesterol phospholipids nefa hcy levels increased whereas serum folic acid decreased dogs ctc compared controls serum ghrelin correlated negatively cholesterol serum leptin correlated positively cholesterol phospholipids results suggest serum leptin ghrelin levels may bring new perspective understanding pathophysiological mechanisms associated ctc serum levels hormones may associated serum levels lipids free
arsenic affected regions cambodia rural water committees planners choose promote various arsenic avoidance arsenic removal water supply systems different costs providing water subsequently born consumer order sustainable volumetric basis arsenic avoidance options considered small scale public water supply treated water provided central tap stand expensive option life cycle cost basis rainwater harvesting protected hand dug wells vendor supplied water cheapest normalized present worth value ranging per cubic meter per year water delivered subsidization capital costs needed make even options affordable lowest quintile range arsenic removal systems considered using adsorptive media competitive large scale public water supply deep tube well systems community level household scale systems range affordable quintile though research field trials needed target cost arsenic removal systems compete opex costs arsenic safe water systems currently available life cycle cost approach valuable method comparing alternatives assessing current water supply practices relate equity ability pay elsevier rights reserved
ionic liquids ils heat transfer fluids htfs limited lack strong ability absorption sunlight hence nanoparticles added pure ils improve thermal optical properties study highly stable ionic liquid nanofluid ionanofiuid first prepared dispersing sic nanoparticles hmim thermophysical optical properties thoroughly investigated htfs application direct absorption solar collectors dacs enhancement thermal properties ionanofluids observed sic ionanofluids could increase specific heat pure hmim degrees respectively increase temperature thermal properties increase viscosity density decreased indicated sic ionanofluids suitable medium high temperature application additionally results optical properties showed sic ionanofluids superior solar absorption material extinction coefficient sic ionanofluids could increase summary advantageous performance ensured potential sic ionanofluids advanced htfs solar energy system believed information guide meaning practical design dac system
recently growing evidence atrial fibrillation common cardiac arrhythmia independently associated risk dementia represents recent frontier high social impact number individuals involved expected increase incidence next years although number potential haemodynamic processes microembolisms altered cerebral blood flow hypoperfusion microbleeds arise connecting links two pathologies causal mechanisms far clear silico approach proposed combines sequence two lumped parameter schemes cardiovascular system cerebral circulation systemic arterial pressure obtained cardiovascular system used input cerebral circulation aim studying role cerebral haemodynamics respect normal sinus rhythm nsr beat recording particular alteration haemodynamic pressure flowrate patterns microcirculation analysed means different statistical tools correlation coefficients autocorrelation functions crossing times extreme values analysis multivariate linear regression models remarkable signal alteration reduction signal correlation nsr less increased probability three four times higher nsr extreme value events emerges peripheral brain circulation described scenario offers number plausible cause effect mechanisms might explain occurrence critical events haemodynamic links relating dementia
variable speed pumped storage power plants promising solution connect synchronous hydrogenerator grid via full rated frequency converter case nominal frequency hydrogenerator chosen independently grid purpose paper investigate nominal frequency affects generator efficiency using converter fed synchronous machine topology nominal speed rotation varied rpm rpm nominal frequency used analytical model salient pole synchronous generator used weight active materials iron losses copper losses mechanical losses calculated different nominal frequencies speeds rotation based generator efficiency curves calculated presented
objectives cardiovascular disease cvd risk calculators developed general population shown inaccurately predict cvd events patients inflammatory joint disease ijd european guidelines cvd prevention recognize presence carotid plaques high cvd risk factor equivalent coronary artery disease patients ijd high prevalence evaluated resulted reclassification patients ijd appropriate cvd risk class recommended lipid lowering treatment methods cvd risk evaluation performed patients ijd using score acc aha risk calculators predict cvd events results ijd patients evaluated including rheumatoid arthritis ankylosing spondylitis psoriatic arthritis ijd patients calculated cvd risk score acc aha indicating need lipid lowering treatment llt however patients low moderate risk calculated score acc aha according guidelines receive intensive llt patients high risk llt considered group reclassified correct treatment adding information presence results reveal considerable reclassification correct cvd risk category adding female patients conclusion high frequency asymptomatic atherosclerosis patients ijd notable impact cvd risk stratification identification reclassify patients recommended cvd preventive treatment group may clinically important elsevier ireland ltd rights reserved
purpose purpose paper twofold first develop theoretical underpinnings using tce second run analysis using advanced tool structural equation modeling sem design methodology approach study conducted construction industry tanzania questionnaire based survey method used total respondents participated study relationships cause effect factors analyzed using sem findings important findings follows cost overrun explained consultant related material related factors disputes explained cost overrun arbitration explained consultant related cost overrun dispute factors litigation explained client related disputes arbitration factors abandonment explained consultant related external related disputes arbitration litigation factors originality value main contributions study theoretical development comprehensive analyses cause effect factors delays construction industry
migratory animals sustainable management african elephant populations within around protected areas major challenge conservation policy many african countries captured seven female elephants representative members family groups different parts tarangire national park tnp tanzania used gps satellite radio tracking november june monitor space habitat use seasonal migrations throughout wet dry seasons patterns home range overlap revealed existence two large clans occupied north central southern parts tnp respectively end dry season elephants southern clan migrated southeast park boundary northern clan remained mostly inside park used periodically wet season core areas nearby game controlled areas natural mortality occurred study two elephants poached outside park human disturbance also affected activity patterns elephants less active day outside inside park home range size varied northern elephants southern elephants migration routes characterised higher cover open closed forest core areas results indicate elephant management must considered across park boundaries migration corridors must protected human disturbance land cultivation society problems linked elephant conservation solved creating alternative sustainable use natural resources enhance livelihood local communities deutsche gesellschaft fur saugetierkunde published elsevier gmbh rights reserved
rapid development space technology operational amplifier widely used basic liner circuit satellite system many charged particles trapped earth magnetosphere particles protons electrons bjts damage caused electrons causes bulk recombination surface recombination increase subsequently current gain decrease transistor gain degradation primary cause parametric shifts functional failures linear bipolar circuits severity electron radiation response correlates electron energy flux therefore important understand electron radiation response different conditions paper tested devices used study npn input bipolar operational amplifiers commercial shelf cots manufactured texas instruments npn input bipolar operational amplifiers irradiated different energy different beam current electrons respectively different bias conditions study electron radiation damage effect experiment using gamma ray radiation conducted compare different radiation damages gamma ray electron radiation total radiation experiments carried gamma ray source xinjiang technical institute physics chemistry radiation dose rates test samples total accumulated dose subsequently room temperature high temperature annealings conducted analyze parametric failure mechanism caused total dose radiation different biases result shows beam current electrons induce damage caused electrons energy mev electrons induce damages mev electrons electron beam current former produces displacement damage latter comparison zero forward biased devices shows different biased devices different radiation sensibility radiation produces damages zero biased devices forward biased devices electron energy beam current forward biased bjt suppress edge electric field thus leading decrease oxide trapped charge interface trapped charge high temperature annealing degradation devices obviously recovered almost return initial value finally result indicates mev mev electron radiation mainly induces ionization damage bipolar operational amplifier
fatigue one disturbing complaints cancer patients often reason discontinuing treatment randomized controlled study tested hypothesis increased morning bright light compared dim light would result less fatigue women breast cancer undergoing chemotherapy thirty nine women newly diagnosed stage iii breast cancer randomized either bright white light bwl dim red light drl treatment instructed use light box min every morning throughout first four cycles chemotherapy multidimensional fatigue symptom inventory administered prior start chemotherapy baseline chemotherapy treatment week cycle ctw last week recovery week cycle crw chemotherapy treatment week cycle ctw last week recovery week cycle crw drl group reported increased fatigue ctw ctw compared baseline significant change baseline bwl group secondary analysis showed increases fatigue levels drl group mediated associated changes sleep circadian rhythms measured wrist actigraphy results study suggest morning bright light treatment may prevent overall fatigue worsening chemotherapy although hypothesis overall fatigue would improve bright light treatment supported lack deterioration total fatigue scores suggests bright morning light may useful intervention chemotherapy breast cancer
objective high rates bipolar disorder found among major depressives seasonal pattern consulting psychiatric departments well among patients seeking primary care reported common latter current study designed assess frequency characteristics among major depressives attending primary care prevalence aspects population methods among patients consulted french general practitioners gps major depression february december could included study met diagnostic statistical manual mental disorders fourth edition criteria seasonal pattern whereas meet criteria two groups compared demographic clinical family history temperamental characteristics results compared patients frequently female married later age first depressive episode showed atypical vegetative symptoms comorbid bulimia stimulant abuse also exhibited lifetime depressive episodes often diagnosed met often bipolarity specifier criteria higher rates bipolar temperaments higher family loading among patients met bipolarity specifier criteria whereas seasonality influenced climatic conditions following independent variables associated according bipolarity specifier female gender comorbid bulimia nervosa hypersomnia number depressive episodes family history substance abuse conclusions seasonal pattern frequent among depressive patients attending primary care france may indicative hidden bipolarity given risks associated bipolarity gps likely major role regard prevention elsevier inc rights reserved
using data american community survey found million people either eligible medicaid children health inusrance program chip appeared likely shop qualified health plan qhp lacked residential high speed internet specifically million people eligible medicaid chip million people appeared likely shop qhp high speed internet home medicaid chip eligible likely shop qhp proportion people living households without internet varied substantially race geography socio demographic characteristics
backgroundhigh levels maltreatment found children identified parents visit emergency department due partner violence substance abuse suicide attempt however unknown children experience psychosocial problems study aims assess levels post traumatic stress anxiety depression behavioural problems health related quality life methodsa cross sectional study conducted six hospitals consecutive families parent visited emergency department due partner violence substance abuse suicide attempt july march children aged years approached participation parents children aged years older filled questionnaires measuring post traumatic stress item version children revised impact event scale cries anxiety depression revised child anxiety depression scale behavioural problems child behavior checklist cbcl youth self report ysr health related quality life pedsql scores participants compared reference data obtained children similar age ranges representative dutch community samples cries revised child anxiety depression scale pedsql cbcl normed cutoff score cries resultsof eligible families participated study participating children score different community children child reported parent reported instruments standardized mean differences total sum scores cries cbcl ysr cbcl pedsql statistically different community children thirty five percent participating children scored cutoff score cries indicating post traumatic stress disorder difference statistically significant community children mean difference conclusionswe found differences psychosocial problems children whose parents visited emergency department due partner violence substance abuse suicide attempt children community samples children scored range post traumatic stress disorder advise healthcare providers pay attention post traumatic stress symptoms
one main functions intelligent tutoring systems providing feedback help students solve problems present novel approach program synthesis used basis automatic hint generation programming tutors instead using state space representation problem solving process method finds set textual edits commonly used students program code given incorrect program synthesizes new programs applying sequences edits solution found edit sequence used provide hints varying levels detail experimental results confirm feasibility approach
objective schizophrenia devastating mental disorder accompanied aberrant structural brain connectivity question whether schizophrenia progressive brain disorder yet resolved thus clear structural alterations occur develop time methods selective review summarized recent findings longitudinal magnetic resonance imaging studies investigating structural brain alterations impact clinical outcome different stages illness subjects ultra high risk developing psychosis patients first episode psychosis chronically ill patients moreover reviewed studies examining longitudinal effects medication brain structure patients schizophrenia results studies pre clinical stages conversion showed pronounced cortical gray matter loss superior temporal inferior frontal regions individuals later made transition psychosis studies investigating patients first episode psychosis revealed decline multiple gray matter regions frontal regions thalamus time well progressive cortical thinning superior inferior frontal cortex studies focusing patients chronic schizophrenia showed gray matter decreased greater extent frontal temporal areas thalamus cingulate cortices especially poor outcome patients studies reported effects white matter microstructure longitudinal course illness conclusion adequate evidence suggest schizophrenia associated progressive gray matter abnormalities particularly initial stages illness however causal relationships structural changes illness courseespecially chronically ill patientsshould interpreted caution findings might confounded longer periods treatment higher doses antipsychotics epiphenomena related illness
moral engagement produces strong emotions help individuals refrain serious criminal behavior youth unable experience emotions based sample adjudicated delinquents using series structural equation models test whether moral disengagement varies level psychopathy relation criminal onset assess stability across gender psychopathic personality features moral disengagement family stress intermixed diverse ways depending severity psychopathic personality gender higher levels psychopathy effect psychopathy criminal onset unmediated however moral disengagement found mediating effects criminal onset lower levels psychopathy study findings lend support hypothesis due core emotional deficits youth high psychopathy unaffected mechanisms moral disengagement results discussed light theories morality psychopathy treatment moral deficits among youthful offenders
background individuals type diabetes increased risk cardiovascular disease alterations circulating lipid levels total cholesterol low density lipoprotein ldl high density lipoprotein hdl triglycerides heritable risk factors cardiovascular disease conduct genome wide association study gwas common rare variants investigate associations baseline lipid levels individuals type diabetes accord clinical trial methods dna extracted stored blood samples accord participants genotyped using affymetrix axiom biobank genotyping array quality control genotype imputation association common genetic variants defined minor allele frequency maf baseline levels ldl hdl tested using linear model rare variant associations maf conducted using suite methods collapse multiple within individual genes results many statistically significant replicate findings large meta analyses non diabetic subjects analyses also confirmed findings studies whereas significant associations cnot hpn asi sirpd appear novel discussion present findings largest gwas lipid levels people type diabetes date identified statistically significant associations lipid levels genes chromosomal regions previously identified meta analyses mostly non diabetic cohorts also identified associations genes based several represent novel findings
paper presents advanced depth intra coding approach video coding based high efficiency video coding hevc standard multiview video plus depth mvd representation paper motivated fact depth signals specific characteristics differ natural signals camera view video approach replaces conventional intra picture coding depth component targeting consistent efficient support video applications utilize depth maps polygon meshes high depth coding efficiency terms minimal artifacts rendered views meshes minimal number triangles given bit rate purpose introduce intra picture prediction modes based geometric primitives along residual coding method spatial domain substituting conventional intra prediction modes transform coding respectively results show solution achieves quality rendered synthesized views bit rate mvd coding video extension hevc hevc high quality depth maps less overall bit rate hevc without related depth tools time combination video computer graphics content substantially simplified geometry based depth intra signals represented surface mesh less triangles generated directly decoding process alternative decoder output
software engineering concerned development advancement huge multiple software intensive systems shelters theories methods tools specification architecture design testing maintenance software systems today development software systems significantly large complex critical use automated approaches systems developed evolve economic timely manner using automated software tools vital successful planning managing projects many automated software tools developed different purposes different situation literature select appropriate software project management tools fairly narrow identification quality project management software among existing tools literature critical paper predict project management tools great quality quality standardized futuristic development project management software
paper proposes parallel computation model self organizing map som neural network applied euclidean traveling salesman problems tsp model intended implementation graphics processing unit gpu platform euclidean plane partitioned appropriate number cellular units called cells cell responsible certain part data network compared existing gpu implementations optimization metaheutistics often based data duplication mixed sequential parallel solving advantage proposed model decentralized based data decomposition designed handling large scale problems massively parallel way required computing resources grow linearly along problem size experiments conducted publicly available euclidean tsp instances cities largest tsplib instance cities largest national tsp instance experimental results show gpu implementations proposed model run significantly faster currently best performing neural network approaches obtain results similar quality elsevier rights reserved
era teaching excellence higher education attracts much attention scholarship conceptual paper examine notion scholarship relation goals purposes higher education scholarship speak value based conceptions good education european tradition encapsulated german term bildung might notion scholarship relate principles practices outputs research argue nuanced understanding legitimate diversity scholarly practices higher education could help individuals develop scholarly careers draw personal values strengths goals also help departments institutions reward education focused scholars leaders equitably finally realising fully synergies education research within holistic scholarship circle strengthen institutions capacities making impact good world
paper proposes real time motion control wheeled mobile robot effective proportional integral derivative pid controller synthesised robot speed process owing shortage chosen gear motor characteristics need model robot gear motor identification computation techniques presented research use intelligent tools order obtain best desired performances closed loop system proposed technique consists comparing presented methods order get best system response apply sets techniques experiments test speed response gear motor using digital signal processor dsp texas instruments integrated digital development tool
empathy basic ability respond affectively emotions others observed early human development study tested italian version empathy questionnaire emque parent scale assessing empathy related behaviors toddlers study completed participants mothers emque measurement model factorial invariance across children gender tested via confirmatory factor analysis highly satisfactory goodness fit indexes found three factor structure contagion attention feelings others prosocial actions loading items furthermore data supported invariance measurement across gender groups results suggest emque reliable instrument investigating empathy prosocial behavior month old children italian context
study aimed investigate differences healthcare service utilization patients without benign prostatic hyperplasia bph using taiwans national health insurance population based database total patients bph age matched patients without bph included outcome variable year utilization healthcare services including number outpatient visits inpatient days costs outpatient inpatient treatments addition separated healthcare services urology services nonurology services analysis found utilization outpatient urological services patients bph outpatient services higher outpatient costs longer length inpatient stay higher patients costs higher total costs comparison group nonurological services patients bph also outpatient services higher outpatient costs longer length patient stay higher inpatient costs higher total costs compared comparison patients also found average total cost fold greater patients bph comparison patients concluded patients bph higher healthcare utilization comparison patients without bph
smart devices smartphones wearable computers today used many purposes devices run various mobile operating systems like android ios symbian windows mobile etc since mobile devices widely used contain personal information subject security attacks mobile malware applications work propose new approach based control flow graphs machine learning algorithms static android malware analysis experimental results shown proposed approach achieves high classification accuracy general high detection rate droidkungfu malware families harmful difficult detect encrypting root exploits reducing data dimension significantly real time analysis
anorexia nervosa mental illness emerges primarily early adolescence mortality rate times higher suicide illness characterized intense fear gaining weight heightened anxiety obstinate food restriction often accompanied excessive exercise spite mounting hunger illness affects females nine times often males suggesting endocrine role etiology relapse rate exceeds yet accepted pharmacological treatments prevent summarize studies laboratory used adolescent female rodents activity based anorexia aba animal model anorexia nervosa goal identifying neurobiological underpinnings disease put forth hypothesis gabaergic mechanism within hippocampus central regulating individual anxiety turn strongly influences individual resilience vulnerability aba particular propose ionotropic gabaa receptors containing subunits alpha delta play exerting shunting inhibition upon hippocampal pyramidal neurons become excitable aba since receptors confer insensitivity benzodiazepines pharmacological profile aba fits lack report indicating efficacy benzodiazepines reducing anxiety experienced individuals anorexia nervosa idea gabaergic system hippocampus regulates resilience vulnerability anorexia nervosa complements current opinions important roles prefrontal cortex amygdala striatum gustatory pathways feeding centers hypothalamus neuromodulators serotonin dopamine etiology disease article part special issue entitled adolescent plasticity elsevier rights reserved
review recent data biological mechanisms depression including monoamine hypothesis diathesis stress model chronobiological model presented biological hypotheses viewed aspect current genetic neurochemical neuroimaging studies well relation different treatment approaches depression seems homogenous disease may caused different factors genetic factors stressful life events play important role young age chronic stress chronobiological disturbances comorbid somatic disease relevant middle aged elderly people moreover recurrent chronic depression accompanied cognitive impairment social dysfunction neurodegeneration factors taken consideration development personalized complex treatment programs
background obesity associated array metabolic disorders insulin resistance hiperinsulinemia impaired tolerance glucose lipid disorders also skeletal joint abnormalities recently pleiotropic role vitamin emphasized obese children frequently present vitamin deficiency greater fat mass associated lower serum concentration vitamin although evidence suggests weight loss may affect vitamin status issue studied extensively thus far aim double blind placebo controlled study assess long term health effects vitamin supplementation vitamin deficient obese children participating integrated weight loss programme methods randomized double blind placebo controlled trial analysing effects vitamin supplementation overweight obese vitamin deficient children participating integrated weight loss programme children randomized receive either vitamin placebo weeks primary endpoints include changes bmi body mass index body composition bone mineral density end study period secondary endpoints changes laboratory parameter reflecting liver kidney function transaminases creatinine glucose homeostasis glucose insulin levels oral glucose tolerance test discussion effects vitamin supplementation obese individuals especially children subjected weight loss program still poorly understood considering physiological processes associated puberty adolescent growth speculate supplementation may enhance weight reduction prevent bone loss obese children deficient vitamin
purpose review literature found significant correlation construction company organisational culture company quality performance purpose paper assess organisational culture profiles indonesian construction companies examine influence companies organisational culture profiles quality management systems based qms iso implementation prior conducting examination examinations relationships among quality management system qms variables design methodology approach methodology employed survey questionnaire construction industry practitioners experience building civil engineering works organizational culture assessment instrument selected due suitability assessing organisation underlying culture findings within examination among qms variables found problematic issues associated implementation qms iso indonesian construction companies affect implementation qms contribute lower level companies business performance also found significant relationship qms implementation companies business performance using competing values framework diagram found construction companies organisational culture characterised clan type reflected employees managed organisation held together organisation success defined leadership style hierarchy focused organisation strategy market type also found different culture profiles different influences qms implementation originality value strong mixed hierarchy market culture needs developed within construction companies indonesia driver support proper successful implementation qms order enhance business performance quality performance oriented indonesian construction industry
extreme apprenticeship recent learning methodology used blended fashion teaching technical subject bash scripting operating systems online learning supported moodle platform particular managing bash programming exercises students behave exercises equally difficult differences arise paper reports design blended learning experience bash programming focusing definition evaluation levels programming exercises students behavior programming supported moodle elsevier ltd rights reserved
describe model understanding interpersonal attraction attraction understood product initial evaluations make others model posits targets evaluated two basic dimensions capacity willingness affective behavioral attraction result evaluations target capacity facilitate perceiver goals needs target potential willingness facilitate goals needs plausibility two dimensional model attraction evaluated vis vis extant literature various attraction phenomena including reciprocity liking effect pratfall effect matching hypothesis arousal effects similarity effect conclude considerable evidence across wide range phenomena supports idea interpersonal attraction principally determined inferences target capacity willingness
human pendrin slca anion transporter mostly expressed inner ear thyroid kidney slca gene mutations associated broad phenotypic spectrum including pendred syndrome non syndromic hearing loss enlarged vestibular aqueduct eva experimental structure pendrin currently available making phenotype genotype correlations difficult predictions transmembrane segments vary number propose novel three dimensional pendrin transmembrane domain model based slcdg transporter resulting topology found include two non canonical transmembrane segments crucial pendrin activity mutation mapping clinically validated pathological mutations shows affect two previously undescribed regions elsevier societe francaise biochimie biologie moleculaire sfbbm rights reserved
nitric oxide plays critical role endothelial functions cellular migration vascular permeability angiogenesis angiogenesis formation new blood vessels pre existing ones carefully regulated process essential reproduction development wound healing previously lab group reported secreted frizzled related protein sfrp could inhibit angiogenesis vitro vivo conditions sfrp belongs family secreted glycoproteins function antagonists canonical wnt signalling pathway although pro apoptotic role sfrp well discussed literature little known regards anti angiogenic property objective study elucidate sfrp implications biology endothelium results demonstrate sfrp causes endothelial dysfunction suppressing cgmp signaling elevating corresponding ros levels imbalance ros levels results apoptosis subsequent leakiness endothelium confirmed vivo texas red annxin cam assay vitro monolayer permeability assay conditions furthermore utilizing peptides synthesized crd domain sfrp results showed peptides able cause endothelial dysfunctions cause apoptosis endothelial cells thereby confirming sfrp mediate anti angiogenic effect independent pro apoptotic property conclusion current study reports sfrp mediated anti angiogenesis occurs result impaired cgmp signaling turn allow elevation redox levels promotion apoptosis endothelial cells elsevier inc rights reserved
single phase inverters widely used connect small scale distributed renewable energy sources grid however unlike three phase system designing vector control single phase inverter challenging paper presents neural network based vector control technique single phase inverter well develop design embedded digital control system implement neural network vector controller using texas instruments tmsf chip paper addresses circuit design effective interface high power inverter system embedded microcontroller well utilize built interrupts achieve efficient digital control implementation user specified sampling time generation high quality pulse width modulated driving pulses moreover embedded software design developed implement neural network vector control single phase inverter laboratory scale single phase inverter system built test evaluate embedded neural network microcontroller hardware experiment assessment shows microcontroller works well using novel neural network vector control mechanism challenging variable distorted hardware experiment conditions
article devoted problem gender identity formation children single parent nuclear families process socialization contemporary russia phenomena blurred gender roles destruction value traditional family common mastering professions traditionally associated opposite sex caused distortion children understanding masculinity femininity concept children single parent families find especially difficult understand formation ideas masculinity femininity female male roles behavioural patterns society children raised single parent households often characterized emotional alienation male parent formation symbiotic relationship female parent results empirical research shown teenagers must close emotionally stable relationships male female parents order develop harmonious adaptive functional gender identity however single parenting necessarily cause destructive consequences child identity dysfunctional relationships may emerge nuclear family authors published elsevier ltd
processing large volumes rdf data require efficient storage query processing engine scale well volume data initial attempts address issue focused optimizing native rdf stores well conventional relational databases management systems volume rdf data grew exponential proportions limitations systems became apparent researchers began focus using big data analysis tools notably hadoop process rdf data paper presents comparative analysis performance presto distributed sql query engine processing big rdf data apache hive evaluate performance presto big rdf data processing map reduce program compiler based flex bison implemented map reduce program loads rdf data hdfs compiler translates sparql queries subset sql presto hive understand
integration coordination make order mto supply chains critical successful execution construction projects study aims investigate potential language action perspective lap analyze way commitments demanded bound fulfilled supply chain members affect integration coordination construction mto supply chains two case studies carried including agents building elevator cut bent rebar supply chains multiple sources evidence exploratory structured interviews site visits document analysis provided invaluable data support analysis evidence reveals information flow problems mto chains traced way commitments among people firms managed along chains also shows kinds failure managing commitments associated incompleteness poor connectivity among study suggests adoption lap provide novel alternative approach understanding information communication problems affect integration coordination mto supply chains construction well identifying possible ways avoid problems
relational learning algorithms mine complex databases interesting patterns usually search space patterns grows quickly increase data size making impractical solve important problems work present design relational learning system takes advantage graphics processing units gpus perform time consuming function learner rule coverage evaluate performance use four applications widely used relational learning benchmark predicting carcinogenesis rodents application chemo informatics application opinion mining application mining health record data compare results using single multiple cpus multicore host using gpu version results show gpu version learner eight times faster best cpu version
term mechanoluminescence refers light emission various organic inorganic materials response mechanical stimuli friction tension fracture compression recently interesting luminescence phenomenon enabled explore various advanced sensor applications review article overall mechanism arises different experimental conditions discussed thoroughly recent research achievements state art sensors based microparticles sralo sao zns zns reviewed new functional smart material sao microparticles used possible substitutive substantial methods structural health monitoring shm systems owing relative simplicity effectiveness detecting arrested propagating crack tips assessing situ structural state means fracture parameters stress intensity factors applicability paint thin films various types ceramics concretes fracture sensors reviewed research sensors based different microparticles noncontact torque sensors based zns flexible pressure sensors impact sensors using zns also reviewed article potential applications using microparticles also briefly discussed
objective study aimed investigate face scan paths face perception abilities children neurofibromatosis type might relate emotion recognition abilities population method authors investigated facial emotion recognition face scan paths face perception children compared chronological age matched typically developing controls correlations facial emotion recognition face scan paths face perception children examined results children displayed significantly poorer recognition fearful expressions compared controls well nonsignificant trend toward poorer recognition anger athough significant difference groups time spent viewing individual core facial features eyes nose mouth nonfeature regions children spent significantly less time controls viewing face whole children also displayed significantly poorer face perception abilities typically developing controls facial emotion recognition deficits significantly associated aberrant face scan paths face perception abilities group conclusions results suggest impairments perception identification interpretation information faces important aspects social cognitive phenotype
paper deals problem fault detection diagnosis induction motor based motor current signature analysis principal component analysis used reduce three phase current space space kernel density estimation kde adopted evaluate probability density functions healthy faulty motor used features order identify fault kullback leibler divergence used index identify dissimilarity two probability distributions allows automatic fault identification aim also improve computational performance order apply online monitoring system kde improved fast gaussian transform points reduction procedure since techniques achieve remarkable computational cost reduction respect standard kde algorithm used online experiments carried using two alternate current motors asynchronous induction machine single phase motor faults considered test developed algorithm cracked rotor tolerance geometry rotor backlash tests carried different load voltage levels show proposed method performance
systematic series septi noni undecithiophenes corresponding pre oligomers five different dendrimer like branched end groups synthesized thermal solid state properties investigated sub stituents vary terms lengths linkers silicon branching points comparison compounds series reveals linker connecting oligomeric core first branching point strongest effect thermal properties furthermore relatively large volume substituents causes surprisingly low overall transition enthalpies entropies oligomers mol mol respectively whereas pre oligomers interrupted conjugation display values range mol mol respectively polarizing optical microscopy pom revealed textures pointing smectic columnar liquid crystalline phases ray afm data representative example typical cubic phases
background development new anti migraine treatments limited difficulty inassessing migraine pain laboratory animals depression activity one diagnostic criteria formigraine mimicked rats goal present study test hypothesis thatdepression home cage wheel running reliable clinically relevant method assess migraine painin rats methods adult female rats implanted cannula inject allyl isothiocyanate aitc onto dura induce migraine pain shown rats recovered implantation surgery days cages containing running wheel home cage wheel running recorded day aitc migraine medication sumatriptan administered hour prior onset dark phase results administration aitc caused concentration dependent decrease wheel running lasted duration magnitude aitc induced depression wheel running consistent following three repeated injections spaced apart administration sumatriptan attenuated aitc induced depressionof wheel running large dose administered immediately following aitc administration wheel running patterns change sumatriptan given naive rats conclusions data indicate home cage wheel running sensitive reliable clinically relevant method assess migraine pain rat
moderate exposure alcohol development leads subtle neurobiological behavioral effects classified umbrella term fetal alcohol spectrum disorders fasds alterations social behaviors frequently observed consequence maternal drinking children fasds display inappropriate aggressive behaviors altered responses social cues rodent models fasds mimic behavioral alterations seen humans rats exposed ethanol development displaying increased aggressive behaviors decreased social investigation altered play behavior work laboratory observed increased wrestling behavior adult male rats following prenatal alcohol exposure pae increased expression glunb containing nmda receptors agranular insular cortex aic study undertaken determine ifenprodil glunb preferring negative allosteric modulator significant effect social behaviors pae rats using voluntary ethanol exposure paradigm rat dams allowed drink saccharin sweetened solution either ethanol throughout gestation offspring months age implanted cannulae aic animals isolated ifenprodil vehicle infused aic min recorded social interaction chamber ifenprodil treatment altered aspects wrestling social investigatory behaviors ultrasonic vocalizations rats exposed ethanol development observed control animals data indicate glunb containing nmda receptors aic play role social behaviors may underlie alterations behavior vocalizations observed pae animals elsevier rights reserved
loss coolant accident loca always significantly considered one important initiating events however probabilistic safety assessment models undoubtedly adopted three groups loca even exact break size boundary used wash reports published awareness importance realistic psa risk informed application several studies tried find realistic thermal hydraulic behavior loca improve psa model purpose research obtain realistic results loca core damage frequency based success criteria analysis using best estimate thermal hydraulics code korea standard nuclear power plant ksnp selected study mars code used thermal hydraulics analysis aims code used core damage quantification one major findings thermal hydraulics analysis decay power well removed normal secondary cooling locas high pressure safety injection locas based thermal hydraulics results regarding new break size boundaries new success criteria five new event trees ets developed core damage frequency new loca ets less conventional psa ets research obtained thermal hydraulics characteristics entire break size loca view deterministic safety assessment also realistic core damage frequency locas using updated information difference results present study conventional knowledge used modify current emergency operator procedures design another nuclear power plant type elsevier rights reserved
semantic web services sws become dominant paradigm service oriented computing one hot issues area distributed computing technology perform business services composition efficiently effectively number years distributed composition sws according functionality increases capability application fulfill user requirements paper describe efficient approach improving performance effectiveness automatic cooperative composition sws systems implements distributed solution based scalable epidemic algorithm discover compose sws systems main idea approach develop hybrid matching technique operates owl process models order ensure high recall reduce number messages exchanged reduce execution time discovering composing sws network moreover matching technique able detect complex matching sws based parameters user request propose similarity measure used compose new discovered heterogeneous collaborative web services large scale distributed systems network satisfying user requirements rank results according similarity score expressing affinities user submitted query experimental results show approach efficient able reduce considerably execution time message overhead preserving high levels distributed discovery composition sws large size networks
paper investigate univariate algebraic attacks filter generators extension fields focus welch gong family stream ciphers main contribution reduce general algebraic attack complexity cipher proving new lower bounds spectral immunity ciphers spectral immunity univariate analog algebraic immunity instead measuring degree multiples multivariate polynomial measures minimum number nonzero coefficients multiple univariate polynomial particular algebraic degeneracy constructions combined attacks based low weight multiples provides much efficient attacks negligible computational complexity best attack breaks primitive given access kilobytes keystream break given access kilobytes keystream break given access half megabyte keystream best attack targeted lte less practical requires computational complexity bits keystream instances significantly lower keystream computational complexity comparison previous estimates side note resolve open problem regarding rank type equation systems used algebraic attacks
introduction pediatric patients hodgkin lymphoma several risk factors venous thromboembolism vte although patients occasionally treated thromboprophylaxis guidelines implemented sweden scarce data adult patients indicate increased risk vte pediatric data largely missing given favorable overall survival reasonably focus preventing complications materials ethods conducted retrospective cohort study including patients registered childhood cancer registry age years diagnosed january december sweden results data retrieved medical records patients six swedish pediatric cancer centers incidence vte symptomatic vte median follow years range five patients treated thromboprophylaxis vte events occurred older age category years one mediastinal mass vte significantly affect treatment caused increased morbidity developed post thrombotic syndrome significant risk factors vte identified conclusions vte relatively common complication treatment causing increased acute long term morbidity however due limited number events could demonstrate risk factors vte would identify patients might benefit thromboprophylaxis elsevier ltd rights reserved
helping college freshmen learn basic computer programming longstanding research topic various environments tools languages developed ease initial steps novice programmers however used full extent artifacts better combined appropriate learning approach work describes pre term workshops offered computer engineering undergraduate freshmen combines use scratch learning environment learning approach based peer support game development strategy challenge response results derived quantitative data analysis surveys artifact analysis students evaluated workshop well found stimulant lightweight good teaching useful well organized conducive learning results suggest effectiveness approach reduce initial difficulties freshmen learning programming concepts
background image guided endovascular interventions gained increasing popularity clinical practice magnetic resonance imaging mri emerging attractive alternative ray fluoroscopy guiding interventions steering catheters remote control mri guidance offers unique challenges opportunities methods review benefits limitations mri guided remote control intervention addressed tools guiding interventions magnetic environment summarized designs remote control catheter guidance include catheter tip electromagnetic microcoil design ferromagnetic sphere tipped catheter design smart material actuated catheters hydraulically actuated catheters remote control catheter guidance systems compared contrasted respect visualization safety performance performance characterized bending angles achievable catheter time achieve bending degree rotation achievable miniaturization capacity design necessary improvements furthering catheter design especially use mri environment addressed hurdles must overcome order make mri guided endovascular procedures accessible regular use clinical practice conclusions guided endovascular interventions remote control steering infancy due issues regarding safety reliability additional experimental studies needed prior use humans
present work high frequency induction heating firstly used densify tib sic ceramic microstructure analysis indicated average grain size sample sintered induction heating smaller sample sintered hot pressing flexural strength fracture toughness improved refining grains increasing relative density order characterize densification behavior tib sic ceramic sintered induction heating typical curve measured linear shrinkage sample calculated used tangential normal grinding forces substituted horizontal vertical forces measured dynamometer order characterize intuitively effect grinding parameters microstructure residual stress mentioned results revealed high frequency induction heating advantages hot pressing results way works applied aid materials engineering design development new materials quality assurance characterization assessment durability elsevier ltd rights reserved
hookah tobacco smoking hts increasing particularly among young adults similar health effects compared cigarette smoking link hts poly tobacco use well documented fewer show association hts alcohol use essential identify factors increase risk addictiveness consequences hts given growing prevalence study examined whether association hts poly tobacco use differed function age alcohol consumption within sample adult cigarette smokers approximately participants reported hts compared non users hookah users likely male highly educated report drug alcohol use binge drinking poly tobacco use less likely heavy smokers cigarettes per day regression analyses predicting number tobacco products used excluding cigarettes hts indicated three way interaction hts frequency alcohol use age association number tobacco products used strongest younger respondents consumed alcohol frequently observed previous studies alcohol important risk factor relationship hts poly tobacco use particularly among younger cigarette smokers links alcohol hts poly tobacco use considered developing hts education prevention materials directed toward younger cigarette smokers findings provide information relevant fda interest addiction potential hts link poly tobacco use elsevier ltd rights reserved
cognitive paradigms allow clinical psychologists examine memory processes false memory production better understand psychopathology current study uses deese roediger mcdermott task investigate true false memories sample social anxiety disorder compared non anxious control group three day delay following list presentation additionally study examines anticipation social stressor stimuli content social versus nonsocial moderators memory effects contrary hypotheses results true memories showed effects involving social anxiety stressor group however nonsocial false memories reported frequently participants social anxiety disorder anticipating speech control participants latter level trend notably lists socially relevant group differences false memory disappeared results suggest individuals social anxiety disorder may vulnerable unexpected memory distortions anticipating social stress
emerging infections caused fungi become widely recognized global phenomenon causing increasing burden disease genomic techniques providing new insights structure fungal populations revealing hitherto undescribed fine scale adaptations environments hosts govern emergence infections cryptococcal meningitis neglected tropical disease responsible large proportion aids related deaths across africa however ecological determinants underlie patient risk infection remain largely unexplored use genome sequencing ecological genomics decipher evolutionary ecology aetiological agents cryptococcal meningitis cryptococcus neoformans cryptococcus gattii across central african country zambia show occurrence two pathogens differentially associated biotic macroecological abiotic physical factors across two key african ecoregions central miombo woodlands zambezi mopane woodlands show speciation cryptococcus resulted adaptation occupy different ecological niches neoformans found occupy zambezi mopane woodlands gattii primarily recovered central miombo woodlands genome sequencing shows neoformans causes human infections region three quarters belonged globalized lineage vni show vni infections largely associated urbanized populations zambia conversely majority neoformans isolates recovered environment belong genetically diverse african endemic lineage vnb show hitherto unmapped levels genomic diversity within lineage results reveal complex evolutionary ecology underpins reservoirs infection likely deadly pathogenic fungi
order increase quality treatment improve safety psychiatric wards learn characteristics patients increased risk mechanically restrained aim present study conducted forensic patients schizophrenia assess whether association temperament character patients experience mechanically restrained recruited male forensic patients schizophrenia without concomitant substance dependence antisocial personality disorder experienced restraint patients assessed temperament character inventory positive negative syndrome scale analysis suggested higher levels novelty seeking intensive psychotic symptoms may represent risk factors use restraints conclude certain personality characteristics may enhance risk use restraints important better understand patients personality traits associated practice
cultural psychology built powerful theoretical edifice yet consolidated methodology analysis thus cultural psychologists adopt models empirical investigation borrowed social science domains taking granted latter consistent theoretical framework result mountain powerful theory ends giving birth mouse empirical analyses runs risk translation language psychology already stated normative canons common sense paper divided two parts first provide arguments support criticisms focusing problematic role played interpreting empirical investigation terms inductive generalization second part paper propose abductive generalization alternative ground empirical investigation psychological phenomena providing arguments highlighting may sustain valid methodology cultural psychology particular attention paid form generalization abstractive generalization abduction leads well search boundary variability basic strategy investigation
ketoprofen used treat painful conditions arthritis sprains strains gout period menstrual pain pain surgical operations eases pain reduces inflammation oral administration side effects especially digestive system recommended caution recent years could note orientation towards topical administration nsaidss hydrogels occupy one first places forms developed topical use five different experimental formulations coded containing carbomer gel forming agent prepared order evaluate influence composition preparation methodology ketoprofen ktp diffusion kinetics release ktp various gel formulations studied using modified franz diffusion cell fitted standard cellophane membrane release profiles experimental formulations well one commercial product fastum gel compared terms diffusion coefficients hydrogel formulated isopropyl alcohol presented slowest release ktp whereas gels using ethanol propylene glycol respectively similar yielding incorporated substance hours moreover preparation ktp gels recommend prior dissolution drug amount alcohol formulation release profile commercial formulation intermediate experimental hydrogels establish drug release mechanism tested hydrogels several kinetic models investigated zero order first order higuchi korsmeyer peppas models tested hydrogel release mechanism follows fickian diffusional model commercial product zero order hydrogels release mechanism represented time independent case relaxational transport iii complex mechanism hydrogel super case transport diffusion associated hydrogel network swelling destructuration probably due sensitivity mechanical action preparation results obtained confirmed ktp vitro release kinetics influenced type alcohol gel basis preparation methodology variables able modify bioactive compound release mechanism
aims standardization stem cell therapy requires application appropriate methods evaluate safety efficacy including long term pharmacovigilance accomplish objective long term registry programme installed methods results analysed patients ischemic cardiomyopathy received intramyocardial bone marrow mononuclear stem cell treatment combined coronary artery bypass grafting cabg cabg alone mortality rate major adverse cerebral cardiac events functional outcome parameters evaluated time period years follow result stratified patient population patients responders non responders furthermore analysis relevant predictors good response bone marrow mononuclear stem cell treatment performed several positive tendencies related stem cells transplantation demonstrated first significant difference major adverse cardiovascular cerebral events observed stem cell control group years follow second improvement left ventricle ejection fraction lvef stem cell group retained years contrast cabg group significant changes lvef years observed addition lvef left ventricle end diastolic diameter independent predictors functional response cell therapy conclusions participants overt heart failure benefit cabg combined intramyocardial injection bone marrow mononuclear cell within group improvement lvef stem cell group remained years contrast cabg group patients improvement lvef lved observed benefited increased life expectancy
paper investigates transient synchronization performance line start permanent magnet synchronous machine pmsm taking account effect rotor cage slot design active permanent magnet volume load inertia first transient performances rotor cage different slot profiles cross sectional area evaluated design optimization pmsm selected rotor slot shape conducted employing adapted multi step taguchi method aim optimization improve transient performance addition optimized rotor design subjected sensitivity analysis exposing design various noise factors system moment inertia permanent magnet volume check robustness design finally results discussed relevant conclusions drawn
study intended review vaginal douching practices associated factors assessment quality life among married turkish women cross sectional study conducted women admitted ankara nafiz korez sincan state hospital turkey march june study group consisted women personal information form used collect data socio demographic characteristics women vaginal douching practices variables believed associated short form determine quality life mean age women study group yrs study prevalence vaginal douching determined vaginal douching mostly performed cleaning feeling comfortable frequency vaginal douching higher premenopausal women women history dyspareunia chronic pelvic pain urinary incontinence history sexual intercourse least week history genitourinary infection using traditional birth control method domain
hyperspectral image superresolution highly attractive topic computer vision attracted many researchers attention however nearly existing methods assume multiple observations scene required observed low resolution hyperspectral image limits application superresolution paper propose new framework enhance resolution hyperspectral images exploiting knowledge natural images relationship low high resolution images low high resolution hyperspectral images proposed framework mapping low high resolution images learned deep convolutional neural network transferred hyperspectral image borrowing idea transfer learning addition study spectral characteristic low high resolution hyperspectral image collaborative nonnegative matrix factorization cnmf proposed enforce collaborations low high resolution hyperspectral images encourages estimated solution extract endmembers low resolution hyperspectral image experimental results ground based remote sensing data suggest proposed method achieves comparable performance without requiring auxiliary images scene
optimization process parameters important aspect manufacturing engineering multi objective optimization process parameters complex process pareto optimal solution methodologies widely used days present investigation focuses three objective multiple performance optimization drilling parameters drilling composite drilling process objective research optimize drilling parameters drilling spindle speed feed speed drill diameter maximizing material removal rate minimizing thrust force surface roughness drilling composites experiments conducted computer numeric control cnc drilling machine carbide drill bit second order regressions developed responses based equations non dominated sorting genetic algorithm nsga used optimize drilling conditions non dominated solution set obtained presented study
backgroundthe development antibiotic resistance bacteria global concern inappropriate prescribing potential exacerbate issue aimed examine patterns prescribing antimicrobial medicines dental practitioners australia methodsdata collected medicare australia prescriptions dental practitioners dispensed concessional beneficiaries examined patterns use time resultsthere overall increase number prescriptions dispensed use standardized dose population antibiotics antifungals concessional population year period use dentally prescribed antibiotics increased amoxicillin commonly prescribed antibiotic accounting prescriptions generally preferential prescribing highest dose formulations use two antifungals increased study period preference amphotericin rather nystatin conclusionsthese data show concerning increase prescribing antibiotics antifungals dentists australia would appear australian dentists may prescribing medicines appropriately however research needed understand prescribing behaviours decision making dentists
irregular shape agricultural products complicates physical engineering analysis therefore precise description irregular product geometric surface form shape significant related analyses used product quality evaluation design agricultural machinery systems study describes reverse engineering application procedure precise description physical attributes related geometric features size shape volume etc agricultural products consideration study three dimensional laser scanner utilised digital model data selected sample agricultural product pecan fruit processed virtual environment scanner software parametric solid modelling design software collected solid models created physical attributes related geometric features agricultural products measured precisely realistic virtual computer aided design cad data provided deeper rheological investigation structural deformation fluid dynamics flow heat transfer analyses products means computer aided engineering cae techniques finally comparative deformation simulation case study concluded study contributes research development agricultural machinery equipment utilisation reverse engineering cad tools
overcome limitations periodic separations proteins batch chromatographic columns carousel multi column setup cms recently suggested theoretically analyzed previous study bochenek marek piatkowski antos chromatogr system feed mobile phase streams subsequently delivered parallel columns mimic countercurrent movement respect fluid flow fluxes system synchronized ensure continuous feed delivery however causes reduction size operating window compared batchwise operating systems study improve performance cms additional process variables considered flow rate gradient feed concentration though altering variables allowed improving separation selectivity extending operating window feed concentration appeared influential parameter affecting process performance moreover procedure practical realization protein separations cms developed including hints process design configuration columns detectors use pumps case study separation ternary mixture proteins cytochrome lysozyme immunoglobulin hydrophobic interaction columns used target product protein intermediate adsorption strength isolated less strongly adsorbed compound elsevier rights reserved
background children sufficiently physically active low levels screen time healthy diet largely influenced parenting practices children parents applying positive parenting practices lower risk overweight obesity therefore investigated effect health promoting online video intervention parents movie models children physical activity screen time healthy diet specific parenting practices parental self efficacy related parenting practices online videos delivered parents primary schoolchildren based real life scenarios methods two armed quasi experimental design used parents primary schoolchildren recruited november december spreading appeal social media contacting primary schools participating parents predominantly high socio economic status ses children overweight obese intervention group participants invited watch online videos weeks specific parenting practices parental self efficacy screen time healthy diet child assessed baseline one four months post baseline repeated measures multivariate anovas used examine intervention effects potential moderating effect age gender child parental ses also examined results significant intervention effects found children screen time healthy diet significant intervention effects found complex parenting practices increase motivating child eat fruit subgroup analyses showed intervention effect actual parenting practices related screen time healthy diet parents older children years old whereas intervention effects parental self efficacy related behaviors stronger parents younger children years old conclusions movie models effective increasing important parenting practices parental self efficacy related screen time healthy diet children therefore current study important first step promoting effective parenting related factors possibly increasing children healthy diet decreasing screen time
benchmark problem modal identification cable stayed bridge proposed research team hong kong polytechnic university taking instrumented cable stayed bridge test bed nineteen sets vibration records known unknown excitations provided invited researchers paper vibration responses bridge series excitation conditions examined estimate wind traffic induced variations dynamic characteristics firstly two output experimental modal identification methods selected secondly bridge monitoring system described nineteen sets vibration records analyzed time domain frequency domain excitations sources blind datasets predicted based analysis excitation conditions known datasets thirdly modal parameters extracted using two selected output modal identification methods identified modal parameters examined respect least two different conditions traffic typhoon induced loadings finally typhoon induced effects dynamic characteristics bridge estimated analyzing relationship wind velocity modal parameters
addition classical exploitation means checking process enactment conformance process models may precious making various kinds predictions process enactment activities carried next set candidate processes actually executed predictions may much important much hard obtained well less common applications process mining related ambient intelligence also prediction performance may provide indirect indications correctness reliability process model paper proposes way make kinds predictions using woman framework workflow management proved able handle complex processes experimental results different domains suggest prediction ability woman noteworthy may useful support users carrying processes
purpose emergency department assessment represents critical often missed opportunity identify elder abuse common serious consequences among emergency care providers diagnostic radiologists optimally positioned raise suspicion mistreatment reviewing imaging geriatric injury victims however little literature exists describing relevant injury patterns radiologists currently receive neither formal informal training elder abuse identification methods present cases begin characterisation radiographic findings elder abuse results findings cases demonstrate similarities suspicious findings child abuse including high energy fractures inconsistent reported mechanisms coexistence acute chronic injuries specific injuries uncommon accidental injury also noted including distal ulnar diaphyseal fracture conclusions hope raise awareness elder abuse among diagnostic radiologists encourage future large scale research increased focus chronic osseous findings addition elder abuse differential diagnoses
delay gratification captures elements temptation self denial characterize real life problems money problem behaviors unhealthy risk taking according fuzzy trace theory decision makers mentally represent social values delay gratification coarse meaningful form memory called gist applying theory developed gist measure delay gratification involve quantitative trade offs delay discounting hypothesize construct explains unique variance beyond sensation seeking inhibition accounting problem behaviors across four studies examine delay gratification gist scale using principal components analyses evaluating convergent divergent validity potentially related scales future orientation propensity plan time perspectives inventory spendthrift tightwad sensation seeking cognitive reflection barratt impulsiveness monetary choice questionnaire delay discounting new item measure captured single dimension delay gratification correlated predicted scales accounted unique variance predicting outcomes overdrawing bank accounts substance abuse overall subjective well results support theoretical distinction reward related approach motivation including sensation seeking inhibitory faculties including cognitive reflection however individuals agreement qualitative gist delay gratification expressed many cultural traditions could reduced dualist distinctions quantitative conceptions delay discounting shedding light mechanisms self control risk taking copyright john wiley sons ltd
study three dimensional blood flow feto placental vasculature system mouse placenta investigated using computational fluid dynamics cfd methods finite element analysis micro computerized tomography micro images used acquire geometry feto placental vasculature system image processing software used calculate morphology placenta flow analyzed numerically compared experimental data received model numerical experimental results agree well experimentally measured time dependent blood velocity data available literature used inlet boundary condition represent fetal blood pulsatile flow velocity profiles pressure distributions investigated different phases unsteady flow results clearly illustrate important role vasculature structure diameter curvature fetal hemodynamics knowledge examined previously data also show bifurcation blood flow velocity decreases significantly transition parent vessel umbilical artery daughter vessels higher total cross sectional area daughter vessels compared parent vessel also observed pressure drop umbilical artery pressure drop across arterial trees obtained study agree well physiological data reported literature moreover velocity profiles bifurcation symmetric finally results secondary flow observed vasculature system study provides foundation understanding modeling complex structure feto placental vasculature system serves first step towards developing new concepts computational analysis feto placental vasculature systems human mouse better understand placenta functions gas nutrient exchange mother fetus published elsevier inc
background study associations seasons blood calcium levels children aged evaluated methods whole blood samples collected children calcium concentrations determined flame atomic absorption spectrometry associations seasons calcium levels analyzed multivariable regression results mean value calcium concentrations mmo overall deficiency overall compared winter children spring summer significant lower calcium concentrations decreased respectively corresponding higher calcium deficiencies spring summer autumn odds ratios respectively moreover seasonality significant girls calcium concentration summer decreased calcium deficiencies summer compared girls winter conclusions seasons significant association blood calcium levels especially girls however impact seasonality children health still unknown clin lab anal wiley periodicals inc
children victims abuse neglect year united states effective screening programs entail broad capture suspected non accidental trauma nat may help identify sentinel injuries facilitate earlier detection psychosocial interventions hopes decreasing recurrent nat confers higher mortality rate purpose article outline essential components hospital based nat screening tools highlight existing programs general tools include several components education sessions healthcare providers identify signs nat automated notes checklists within electronic medical record prompt specialty referrals multidisciplinary team experts address needs children acute care setting elsevier inc rights reserved
home visiting effective preventive intervention improve parenting outcomes risk new mothers thereby optimizing subsequent child development history maltreatment childhood common mothers participating home visiting yet extent history related parenting outcomes home visiting unknown current study evaluated whether mothers history maltreatment childhood respond less favorably home visiting examining direct indirect pathways subsequent parenting stress key parenting outcome affecting child development first time mothers age range participating one two home visiting programs healthy families america nurse family partnership evaluated enrollment month post enrollment assessments researchers administered measures maternal history maltreatment childhood depressive symptoms social support parenting stress maternal history maltreatment childhood predicted worsening parenting stress month assessment mediation modeling identified two indirect pathways one involving social support enrollment one involving persistent depressive symptoms home visiting explained relation history maltreatment childhood parenting stress month assessment ways improve preventive effects home visiting mothers history maltreatment childhood identification relevant intervention targets ideal time administration discussed
purpose united states pediatric legislation introduced improve children health european union eupl force since pls facilitate additional pediatric research primarily adult drugs eupl declares forces market sufficient children without pediatric investigation plan new drugs longer registered european union new ways facilitate drug development rare pediatric diseases proposed methods eupl implications modern labels medical decision making discussed findings modern drug labels constituted step eminence based towards data based medical decision making however approval regulatory authorities replace knowledge transfer medicine continued university education conferences consensus papers children successfully treated label drugs pediatric oncology many diseases describing children therapeutic orphans reflected overestimation drug labels underestimation nonregulatory systematic clinical testing therapeutic breakthroughs occurred example acute myelogenous leukemia cystic fibrosis rare diseases need new innovative drugs therapeutic concepts breakthroughs elsevier journals inc rights reserved
study aimed observe incidence rates hamstring strain injuries hsis across different competition levels ages penn relays carnival year period injuries treated medical staff recorded type injury anatomic location event injury occurred competition level demographic data documented absolute relative hsi per participants determined odds ratios ors calculated sexes competition levels events throughout study period athletes registered participate penn relays carnival hsis treated medical team high school girls displayed lesser risk hsi high school boys masters athletes likely high school college level athletes suffer hsi relay displayed greater likelihood hsi compared relay high school boys masters level athletes likely suffer hsi higher risk events compared events
taqia polymorphism associated addictions dopamine related traits located ankyrin repeat kinase domain containing gene ankk nearby gene dopamine receptor since ankk function unknown taqia associated traits explained differences report ankk studies mouse human brain using quantitative real time pcr western blot immunohistochemistry flow cytometry ankk mrna protein isoforms vary along neurodevelopment human mouse brain mouse adult brain ankk located astrocytes nuclei postmitotic neurons neural precursors neurogenic niches embryos adults nuclei neural precursors show significant variation ankk intensity demonstrate correlation ankk cell cycle cell synchronization experiments showed significant increment ankk kinase mitotic cells ankk kinase overexpression affects phase found modulated ankk alleles apomorphine treatment furthermore embryonic neurogenesis ankk expressed slow dividing neuroblasts rapidly dividing precursors mitotic cells results suggest role ankk cell cycle neural precursors thus providing biological support brain structure involvement taqia associated phenotypes
digital restoration film content historical value crucial preservation cultural heritage also digital restoration relevant application area various video processing technologies developed computer graphics literature also involves multitude unresolved research challenges currently digital restoration workflow highly labor intensive often heavily relies expert knowledge revisit key steps workflow propose semiautomatic methods performing build upon state art video processing techniques adding components necessary enabling restoration chemically degraded colors film stock removal excessive film grain spatiotemporal filtering iii contrast recovery transferring contrast negative film stock positive show applied individually tools produce compelling results applied concert significantly improve degraded input content building conceptual framework film restoration ensures best possible combination tools use available materials spie
paper present way insert reliability models expansion planning electrical network real data coming georeferenced database geographic information system gis company software friendly interface developed real network used example computational results presented elsevier ltd rights reserved
background clinical psychiatry always limited lack objective tests substantiate diagnoses lack specific treatments target underlying pathophysiology one area twin failures frustrating major depression due considerable progress basic clinical neurosciences sleep wake cycles underlying circadian systems situation rapidly changing discussion development specific behavioral pharmacological strategies target basic regulatory systems driving renewed clinical interest explore extent objective tests sleep wake cycles circadian function namely measure timing synchrony circadian dependent physiology well daytime activity nighttime sleep patterns used identify sub class patients major depression disturbed circadian profiles summary unique pathophysiology characterized highly personalized treatment plan proposed monitored new treatments designed old treatments evaluated basis effects objective measures sleep wake cycles circadian rhythms related metabolic systems
non adherence remains perplexing issue hiv treatment decades research supporting efficacy antiretroviral therapy non adherence medication remains important issue patients non adherent anti retroviral therapy art appears mismatch model illness necessity art treatment propose active visualisation technique could utilised improve understanding treatment subsequently adherence individuals living hiv risk infection discuss theoretical background highlight initial evidence suggesting utility active visualisation discuss active visualisation could utilised live demonstration improve adherence art pre exposure prophylaxis medications
feeling synchrony fundamental social activities prosocial behaviors however little known behavioral correlates feeling modulation intergroup differences previously showed subjective feeling synchrony subjects involved mirror imitation task modulated objective behavioral measures well contextual factors task difficulty duration task performance present study extended methodology investigate possible interindividual differences hypothesized romantic relationship professional musician modulate implicit explicit synchronization feeling synchrony well ability detect synchrony third person perspective contrary hypothesis find significant differences people romantic relationship control subjects however observed differences musicians control subjects implicit synchrony spontaneous synchronization walking results revealed musicians never met spontaneously synchronized movements earlier among control subjects better people sharing romantic relationship moreover explicit behavioral synchronization tasks mirror game musicians reported earlier feeling synchrony less speed errors control subjects interaction tasks difficulty differences appeared tasks intermediate difficulty finally subjects judge synchrony third person perspective musicians better performance identify present videos taken together results suggest professional musician play role feeling synchrony underlying mechanisms
study designed investigate clinical application significance bulbocavernosus reflex bcr test diagnosing diabetic neurogenic bladder dnb female subjects study female patients dnb female normal controls subjected nerve conduction study ncs four limbs bcr test data analyzed compared corresponding diagnostic sensitivities discussed mean bcr latency female dnb patients significantly prolonged compared control group suggesting pudendal nerve injuries female dnb patients moreover dnb patients categorized according diabetes course compared group diabetes course longer control group furthermore compared controls mean bcr latency prolonged dnb patients without ncs abnormalities limbs nevertheless significant difference observed bcr latency dnb patients without ncs abnormalities significantly increasing trends also observed ncs bcr abnormality rates along increased diabetes course importantly compared ncs limbs bcr test sensitive diagnosing dnb female subjects overall findings suggest bcr test would help assess pudendal nerve injury female dnb patients might potential diagnostic tool clinic
serotonin hydroxytrympamine one phylogenetically oldest neurotransmitters serotonergic system among earliest developed neuronal systems serotonin critically involved regulating multiple physiological functions acting via heterogenic receptor family includes protein coupled receptors ligand gated ion channels although serotonergic neurons comprise widely distributed complex network targets nearly every brain structure serotonin mediated signalling strict temporal spatial control imbalance serotonergic signalling implicated many pathophysiological conditions including schizophrenia alzheimer disease depression anxiety addition well established role neurotransmitter serotonin involved many aspects neural development including neurite outgrowth somatic morphology regulation growth cone motility synaptogenesis control dendritic spine shape density morphogenic effects serotonin developmentally regulated serotonin availability sensitive developmental stages modulate formation functions behaviourally relevant neuronal networks adulthood provide overview molecular mechanisms responsible morphogenic effects serotonin elicited different receptors neurons also discuss role serotonin receptor mediated morphogenic signalling development maintenance pathophysiological conditions elsevier ltd rights reserved
aim study investigate effect silane pretreatment universal adhesive bonding lithium disilicate glass ceramic composite resin ips max ceramic blocks etched hydrofluoric acid randomly assigned one eight groups treated one four universal adhesives two silane free adhesives two silane containing adhesives without silane pretreatment bonded specimens stored water shear bond strength sbs ceramic resin interface measured evaluate bond strength debonded interface sbs test analysed using field emission scanning electron microscopy determine failure mode light microscopy performed analyse microleakage marginal sealing ability silane pretreatment significantly positively influenced sbs marginal sealing ability universal adhesive groups sbs increased percentage microleakage decreased pretreatment without pretreatment sbs percentage microleakage significantly different silane containing universal adhesive groups silane free groups cohesive failure main fracture pattern results suggest additional silane pretreatment effectively improve bonding strength marginal sealing adhesives lithium disilicate glass ceramics bonding performance silane containing universal adhesives without pretreatment similar silane free adhesives
crucial operation maintenance data quality relational databases remove tuples mutually describe entity duplicate tuples replace tuple minimizes information loss function combines multiple tuples one called fusion function paper investigate fusion functions attributes values sorted means order relation reflects notion generality shown providing order relation priori let alone keeping date costly operation therefore dynamical order construction doc algorithm proposed constructs order relation automated fashion upon inspecting data need fused order relations immediately deployed framework selectional fusion functions fusion functions adopt sort select principle fusion functions investigated closely terms selection strategies experimental evaluation method shows influence parameters benefit respect using fixed predefined taxonomy elsevier rights reserved
recently vernier permanent magnet vpm machines one special case magnetic flux modulated mfm machines benefiting compact simple construction low speed high torque characteristics receiving increasing interest paper vernier structure integrated axial flux machine obtain magnetic gear effect produce improved torque density direct drive wind power generation application another advantage proposed machine stator flux rotating speed relatively high shaft speed low benefit sensorless control strategy easily implemented wide speed range paper improved sliding mode observer smo proposed estimate rotor position speed proposed machine estimated shaft speeds maximum power point tracking mppt control strategy applied maximize wind power extraction machine design sensorless mppt control strategy verified finite element analysis experimental verification
since proposal ntru cryptosystem many variants proposed researcher using different different algebraic structure article try explore existing variants ntru cryptosystem comparative study copyright john wiley sons ltd
introduction wide range preclinical studies testing cellular therapies repair injured spinal cord yet remain challenge translate inconsistencies efficacy limited number patients acute subacute sci high costs clinical trials area covered paper focusses therapeutic potential neural precursor cells npcs provide cellular components capable promoting repair enhancing functional improvement following spinal cord injury sci authors discuss challenges npc transplantation respect different populations npcs glial neuronal lineages timing treatment relative acute chronic injury progress ongoing clinical trials expert commentary preclinical research continue elucidate mechanisms recovery associated npc transplants including increasing partnership related fields spinal atrophies multiple sclerosis clinical trials landscape grow include acute chronic sci increased partnership strengthened communication biotechnology government academia also growing effort develop better biomarkers imaging outcome measures detailed assessment neurological function measures quality life
severity number attacks computer networks rapidly increasing existing security solutions concentrate resisting one several attacks propose integrated router security framework called trustr able defend various types attacks trustr integrates collaborating security primitives including cryptography based security mechanisms trust management system trusted platform module simple efficient method detecting deceptive routing messages also proposed deployment trustr introduced simulation results show trustr effective resisting attacks improving network performance
structural properties nonionic spherical micelles relatively large extensions interfacial layer investigated size dependences adsorption interfacial tension chemical potential obtained familiar thermodynamic relationships gibbs laplace equations differential equation chemical potential concept hydrophilic lipophilic balance used method applied micelles formed surfactant solutions homologous series tetraethylene glycol alkyl ethers region existence micellar solutions structural characteristics interfacial layer micelles determined interfacial tension minimum corresponding ideal hydrophilic lipophilic balance micelle interfacial layer detected chemical potential negative range homologous series derivative respect tension radius also negative
health issues elderly people may lead different injuries obtained simple activities daily living potentially dangerous unintentional falls may critical even lethal patients due heavy injury risk project wireless sensor systems telecare application elderly people developed robust fall detection algorithm wearable wireless sensor optimise algorithm hardware performance test field designed accelerometer based wireless fall detector main considerations functionality algorithm applied chosen hardware power efficiency run long time picked tested parts built prototype optimised firmware lowest consumption tested performance measured consumption parameters paper discuss design choices present results work
paper investigates effect tracking errors heliostats used solar tower power plants proposes approach based low cost distributed electronics capable limiting impact analysis carried parallel model sets specifications design closed loop solar tracker based low cost six axis digital compass proof concept system devised test accuracy proposed strategy approach allows solar tracker perform run time detection correction heliostat tracking errors accuracy mrad azimuth angle less mrad altitude angle thus leading higher concentration ratio open loop solar tracker elsevier ltd rights reserved
background aims performed multicenter study determine whether transabdominal bowel wall ultrasonography noninvasive procedure require radiation used monitor progression crohn disease methods performed month prospective noninterventional study sites germany december september study included adult patients experienced flare defined harvey bradshaw index score patients received treatment intensification tumor necrosis factor antagonists ultrasound parameters clinical data assessed baseline months primary endpoint change ultrasound parameters within months study enrollment results patients included bowel wall alterations either within terminal ileum segments colon months ultrasonographic examination showed significant improvements nearly ultrasound parameters including reductions bowel wall thickening stratification decreased fibrofatty proliferation increased signals color doppler ultrasound parameters months median harvey bradshaw index scores decreased baseline months improvement bowel wall thickness correlated reduced levels reactive protein months conclusions multicenter prospective study found ultrasonographic examination used monitor disease activity patients active bowel ultrasonography seems ideal follow method evaluate early transmural changes disease activity response medical treatment german
flow around circular cylinder classic scenario invariably draws attention fluid mechanics circle relevant studies theoretical practical significances however experiments conducted transcritical reynolds number regime due limitations wind tunnel modeling technique makes obtained results inapplicable full scale conditions end field measurements wind induced pressures meter high large cooling tower conducted enrich experimental results flow past circular cylinder transcritical regime besides wind effects low also obtained tests rigid cooling tower model wind tunnel considering types wind speeds types surface roughness flow fields employing data obtained field measurements wind tunnel model tests variations static dynamic flow characteristics increasing studied found increase drag coefficient smooth walled tower uniform flow field decreases dramatically critical regime increases slowly supercritical regime accord roshko achenbach results smooth walled tower base pressure coefficient pressure coefficient increase significantly increase critical supercritical regimes qualitatively accord shih results finding strouhal number supportive shih result shedding rough cylinder persists throughout range tested importantly special attention paid independence phenomenon fluid flow typical phenomenon occurring transcritical regime results indicate independence exists range circular cylinder relative roughness greater increased free stream turbulence also induce independence probably exists narrow low range considering flow mechanism reasonable explanation found independence phenomenon critical supercritical regimes narrow move lower range increase surface roughness increase free stream turbulence independence occur low
microsponge recent novel technique control release well target specific drug delivery system therefore many researchers attracted towards microsponge drug delivery system microsponge technology introduced topical drug products increase controlled release active drug skin order reduce entry drug blood maintain drug skin surface microsponge technology offers entrapment ingredients improved stability reduced side effects increased elegance enhanced formulation flexibility various studies shown result microsponge systems non irritating non allergenic nonmutagenic non toxic technology used currently cosmetics counter otc skin care sunscreens prescription products technology best feature self sterilizing article focused method preparation characterization particle size distribution surface morphology porosity density covered advantages disadvantages application microsponge
acute myeloid leukemia aml characterized clinical biological heterogeneity despite advances understanding pathobiology chemotherapy directed management remained largely unchanged past years however various novel agents demonstrated clinical activity either single agents isocitrate dehydrogenase idh inhibitors vadastuximab combination standard induction consolidation diagnosis salvage regimens relapse classes agents described review include novel cytotoxic chemotherapies cpx vosaroxin epigenetic modifiers guadecitabine idh inhibitors histone deacetylase hdac inhibitors bromodomain extraterminal bet inhibitors fms like tyrosine kinase receptor flt inhibitors antibody drug conjugates vadastuximab well cell cycle inhibitors volasertib cell lymphoma bcl inhibitors aminopeptidase inhibitors agents actively undergoing clinical investigation alone combination available chemotherapy
rationale research suggests among whites racial bias predicts negative ingroup health outcomes however little known whether racial bias predicts ingroup health outcomes among minority populations objective aim current research understand whether racial bias predicts negative ingroup health outcomes blacks method compiled racial bias responses blacks whites generate county level estimates blacks whites implicit explicit biases towards examined degree biases predicted ingroup death rate circulatory related diseases results counties blacks harbored implicit bias towards whites blacks died higher rate additionally consistent previous research counties whites harbored explicit bias towards blacks whites died higher rate links racial bias ingroup death rate independent county level socio demographic characteristics racial biases group county conclusion findings indicate racial bias related negative ingroup health outcomes blacks whites though relationship driven implicit bias blacks explicit bias whites elsevier ltd rights reserved
global software development gsd fundamentally different paradigm traditional software engineering observed continuous growth lot acceptance last years organizations gain many advantages gsd face additional challenges observed collocated teams environment literature reveals existing process improvement frameworks explicitly accommodate complex challenging needs gsd literature found one major challenges weak monitoring controlling distributed teams study therefore developed process improvement framework improve monitoring controlling distributed teams gsd environment proposed framework constructed using grounded theory methodology validated using methods face validity content validity construct validity convergent validity discriminant validity detailed analysis depicts proposed framework valid framework global monitoring control gsd environment
data structures explored several domains computer applications order ensure efficiency data store retrieval however data structures present different behavior depending applications used three dimensional interactive environments offered techniques virtual reality require operations loading manipulating objects real time realism response time two important requirements efficient representation geometrical models plays important part simulation may become real paper present implementation comparison two topologically efficient data structures compact half edge mate face representation objects three dimensional interactive environments structures tested different conditions processors ram memories results show structures used efficient manner mate face structure shown efficient manipulation neighborhood relationships compact half edge efficient loading geometric models also evaluated data structures embedded applications biopsy simulation using virtual reality considering deformation simulation method applied virtual human organs results showed use allows building applications considering objects high resolutions number vertices without significant impact time spent simulation therefore use contributes construction realistic simulators elsevier inc rights reserved
objective study aimed test expression maspin invasive fungal rhinosinusitis explore value diagnosing invasive fungal rhinosinusitis methods forty two fungal rhinosinusitis cases invasive non invasive selected experimental group chronic rhinosinusitis cases comprised control group maspin expression assessed nasal mucous membrane specimens immunohistochemical staining results compared control group maspin expression regulated fungal rhinosinusitis group furthermore staining score maspin lowest invasive fungal rhinosinusitis group compared non invasive fungal rhinosinusitis group control group maspin staining score critical value diagnosis invasive fungal rhinosinusitis sensitivity specificity per cent per cent respectively conclusion results study suggest maspin staining score may biomarker effective rapid diagnosis invasive fungal rhinosinusitis
human brain asymmetries well described intriguingly number asymmetries brain phenotypes shown change throughout lifespan recent studies revealed topological asymmetries hemispheric white matter networks human brain however remains unknown whether topological asymmetries evolve adolescence young adulthood critical period constitutes second peak human brain cognitive development address question present study included large cohort healthy adolescents young adults diffusion structural magnetic resonance imaging acquired construct hemispheric white matter networks graph theory applied quantify topological parameters hemispheric networks adolescents young adults rightward asymmetry global local network efficiencies consistently observed hemispheres degree asymmetry significantly decreased young adults nodal level young adults exhibited less rightward asymmetry nodal efficiency mainly around parasylvian area posterior tempo parietal cortex fusiform gyrus developmental patterns network asymmetry provide novel insight human brain structural development adolescence young adulthood also likely relate maturation language social cognition takes place period
self healing materials able repair automatically external normal damages special property self healing materials could enhance service life ensure safety using materials especially mechanically therefore become new emerging smart material specialty manage damages instead traditional materials avoid self healing hydrogels based constitutional dynamic chemistry received lot attentions recently intrinsic dynamic structures namely cross linked polymer networks dynamic bonds dynamic chemistry bonds contain non covalent bonds reversible covalent bonds non covalent bonds weak effects include hydrogen bonds van der waals forces coordinative bonds hydrophobic effects etc reversible covalent bonds usually include chemistry bonds could reversible mild conditions imine bonds disulfide bonds acylhydrazone bonds hydrogels dynamic cross linked networks could manage external damages repair self healing materials also gain multi responsive properties environmental stimuli latter specialty comes adptive property dynamic bonds react changes reaction environments like temperature chemical reactants thus building foundation develop self healing hydrogels multi functional self adaptive smart soft matter great significance research enrich multi functional materials besides hydrogel soft matter long vastly used biomedical applications due superior biocompatibility resemblance biological tissues mainly components usually hydrogel water playing important role biomedical applications drug delivery systems cell culture tissue engineering manmade biomimetic materials developing multi functional smart soft matter self healing property self healing hydrogels would quite helpful emerging field unexpected biomedical materials paper reviews recent works self healing hydrogels based dynamic chemistry future biomedical applications systems based multiple hydrogen bonds coordination effects hydrophobic effects acylhydrazone bonds imine bonds specifically discussed
paper examines determinants adoption rainwater harvesting conservation techniques semi arid tharaka sub county eastern kenya given erratic rainfall characterises tharaka rainwater harvesting conservation critical improvement agricultural production study conducted two agro ecological zones respondents interviewed majority farmers practising rainwater harvesting conservation techniquesan indication awareness benefits situ technologies frequently practised micro catchment macro catchment technologies institutional efforts supporting adoption micro catchment macro catchment techniques recent past correlation results showed number techniques practised influenced number years spent school arable land size labour availability number livelihood options soil quality unlikely determinant rainwater harvesting majority farmers rated good fair chi squared results suggest choice rainwater techniques primarily informed desire harvest conserve soil moisture improve soil quality although adoption technologies encouraging assessment efficiency context physical attributes soil characteristics slope rainfall amount area would add value copyright john wiley sons ltd
pediatric practical dentistry beside great variety direct dental restoration materials dentist must take account several factors morpho structural particularities temporary teeth clinical situation physician performance behavioural features children last least quality chosen material thus investigated behavior glass ionomers cements occlusal stress determining mechanical properties study aims determine vertical compressive strength values one mechanical properties filling materials strength materials useful research occlusal forces exerted future restorations used two glass ionomer cements resin modified glass ionomer cement tested obtain comparative data resistance vertical compression
study investigates contrasting sceneries community based tourism wenchuan earthquake focuses potentials tourism transformations towards green economies tourism environment linked sustainable relationship potentials community based tourism directed transformations towards green economies qualitative research design used examine contrasting sceneries specific green elements community based tourism qiang people fortress village mao county sichuan province west china discuss tourism compatible human wellbeing demonstrating commitment sustainable development study argues potential economic social environmental costs tourism need considered evaluating loss community benefits toward sustainability green elements suggest potential community based tourism transformations towards green economies involving green agricultural green building green energy green governance green service green consumption study contribute debate relationship tourism environment sustainability green economies well critique learned community development green tourism mountainous regions inevitable natural disasters
abstract article aims investigate sub synchronous resonance issue may caused wind farms connected electrical network series compensated transmission line two wind turbine types based doubly fed induction generator permanent magnet synchronous generator modeled sub synchronous resonance analysis detail proportional integral parameters control loops optimized based computational intelligence method studies carried ieee first benchmark model small signal analysis conducted reveal impacts series compensation level parameters proportional integral controllers wind speed existing oscillatory modes
poor sleep depression anxiety common patients inflammatory bowel diseases ibd associated increased risk relapse poor outcomes effectiveness therapies improving psychosocial outcomes unclear important question examine increasing selectivity therapeutic agents prospective cohort enrolled patients moderate severe starting biologic therapy vedolizumab anti tumor necrosis factor alpha agents anti tnf sleep quality depression anxiety measured using validated short form nih promis questionnaires assessing sleep mood quality past days disease activity assessed using validated indices improvement sleep mood scores baseline assessed regression models used identify determinants sleep quality study included patients ibd anti tnf vedolizumab among half women mean age years combined cohort observed statistically significant meaningful decrease mean scores baseline week among vedolizumab users sleep score improved baseline week persisted week parallel reductions depression anxiety also noted week observed difference improvement sleep depression anxiety vedolizumab anti tnf use week vedolizumab anti tnf biologic therapies associated improvement sleep mood quality ibd
aim observe whether differences effects electro acupuncture moxibustion mox rats visceral hypersensitivity methods mox degrees degrees applied shangjuxu bilateral acupoints model rats visceral hypersensitivity responses wide dynamic range neurons dorsal horns spinal cord observed extracellular recordings mast cells activity colons rats assessed hydroxytryptamine hydroxytryptamine receptor htr htr expressions colons measured results compared normal control group responses wide dynamic range neurons dorsal horn spinal cord increased groups mox degrees degrees groups degrees degrees degranulation rates expression htr htr colon mox degrees group decreased compared model group degranulation rates htr htr conclusion analgesic effects mox degrees greater mox degrees
far systematic reviews suggested increased risk cardiovascular diseases cvd psoriatic patients though results conflicting aim study update current level evidence systematic search medline embase cochrane central register databases total high quality observational studies estimating incidence cvd included patients mild psoriasis increased risk stroke hazard ratio myocardial infarction cardiovascular death risks stroke cardiovascular death increased patients severe psoriasis conclusion updated meta analysis confirmed patients psoriasis increased risk cvd especially severe psoriasis
background purpose randomized controlled trials rcts accepted gold standard assessing effectiveness clinical interventions rarely reported pediatric surgery rcts submitted british association paediatric surgeons baps annual congress last years adequately designed large enough produce valid result methods abstracts accepted annual baps congress meetings examined collaboration senior health services researcher quality design methodology statistical analysis conclusions adequacy sample size assessed identifiable clinical rcts results accepted abstracts rcts clinical interventions trials relevant primary end point specified outset study none documented method randomization one abstract mentioned blinding respect intervention outcome measure sample sizes inadequate detect even large clinical differences date one rcts published english language peer reviewed journal conclusions clear guidelines exist conduct rcts yet compliance standards rarely documented abstracts pediatric surgical rcts presented baps sample sizes inadequate rcts pediatric surgery difficult perform specialty would benefit well designed carefully conducted multicentre clinical rcts advance evidence based practice copyright elsevier science usa rights reserved
background study part project orthopaedics evaluation demand orthopaedic work force year initiated professional association orthopaedists bvo aim estimate prospective number orthopaedists sufficient medical care musculoskeletal disorders injuries methods main data source official statistics discharge rates german population forecasts federal office statistics wiesbaden germany univariate forecasting analysis done using granger newbold method results diagnostic categories musculoskeletal disorders arthropathies dorsopathies rheumatism osteopathies increase four fold three four diagnostic categories injuries dislocations sprains strains contusion injuries open wounds decrease percent diagnostic category fractures increase percent stratified analyses gender age reveal women persons years old often affected musculoskeletal disorders injuries conclusions demographic changes changes utilization inpatient care lead substantial increase hospital cases presented results looked together confidence limits interval estimations addition independent external factors new prospective payment system drgs influence hospital admission rates well
paper proposes new phase current reconstruction technique interleaved three phase bidirectional converters using single current sensor proposed current reconstruction algorithm single current sensor employed link link current information sampled either peak valley point pulse width modulation pwm carriers regularly obtained current information phase currents reconstructed single pwm cycle digital current controller applied achieve current balancing phase compare previous multiple current sensor method proposed strategy reduces number current sensors interleaved three phase bidirectional converter well reducing potential current sensing error caused non ideal characteristics multiple current sensors effectiveness proposed method verified experiments based three phase bidirectional converter prototype automotive battery charging application
therapies immunomodulatory neuroprotective properties thought greatest promise reducing severity progression multiple sclerosis several reactive oxygen ros reactive nitrogen species rns implicated inflammatory mediated damage central nervous system cns animal model experimental autoimmune encephalomyelitis eae tempol hydroxy tetramethylpiperidine oxyl stable nitroxide radical potent antioxidant activity goal studies investigate immunomodulatory effects therapeutic potential orally delivered tempol mouse eae model mice receiving tempol chow libitum weeks prior induction active eae showed delayed onset reduced incidence disease compared control fed animals reduced disease severity associated limited microglial activation fewer inflammatory infiltrates tempol effects immunomodulatory immunosuppressive cells produced less interferon gamma tumor necrosis factor alpha tempol fed mice exhibited shift towards type antibody responses myeloid myeloid dendritic cells tempol fed eae animals significantly lower levels mhc class expression controls also significantly reduced tempol administration associated enrichment cell populations foxp regulatory populations tempol reduced severity clinical disease administered induction disease also onset clinical symptoms exclude effects cell priming vivo tempol tested passive transfer encephalitogenic cells found reduce incidence peak severity disease protection associated reduced infiltrates relative sparing neurofilaments axons ability oral tempol reduce inflammation axonal damage loss demonstrate anti inflammatory protective properties significant promise treatment related neurological disorders authors published elsevier inc
development novel medicines important responsibility researchers field pharmaceutical sciences however discovery new therapeutically effective without side effects easy job think limiting step drug discovery process evaluating therapeutic effects candidate drugs overcome problem would like propose novel approach drug discovery silkworms
contests one best ways teach serves gamification learning process cyber security field two additional unique obstacles first want teach criminal activities second actually really know future cyber world actually need problems solved asking solve hard box computer programming tasks correlated current cyber security techniques
growing body research suggests social contextual factors desires goals affective states stereotypes shape early perceptual processes suggest generative bayesian approach towards perception provides powerful theoretical framework accommodate high level social factors influence low level perceptual processes earliest stages review experimental findings show social factors shape perception evaluation people behaviour socially relevant objects information subsequently summarize generative view perception within bayesian brain show framework account pervasive effects top social knowledge social cognition finally sketch theoretical experimental implications social predictive perception indicating new directions research effects neurocognitive underpinnings social cognition elsevier inc rights reserved
methamphetamine related psychosis growing public health concern individuals transient amphetamine related psychotic symptoms considered risk future development enduring psychotic illness prioritized early intervention integrated care across substance use mental health services
objectives patients bipolar disorder reported difficulties inhibition even euthymic state however literature cortical activity associated response inhibition remains ambiguous study investigates inhibition euthymic using electrophysiological measures controlling effects specific medications methods twenty patients compared eighteen healthy controls nogo task electroencephalogram recorded behavioral event related potential erp measurements analyzed two groups medication effects controlled analysis results patients marginally reduced nogo amplitudes increased nogo amplitudes compared healthy controls patients using benzodiazepines excluded study behavioral differences groups found conclusions reduced nogo amplitudes reflect aberrant conflict detection early stage inhibition process addition increased nogo amplitudes despite normal task performance reflect overactive cortical system simple inhibition task significance difficulties early stages inhibition appear compensated increased cortical activation study extends current knowledge regarding cortical activations relating inhibition international federation clinical neurophysiology published elsevier ireland ltd rights reserved
turbine blade surfaces cooled jet flow expanded exit holes eehs prevailing hot gas flow flow eeh must designed form film cool air blade computational analyses performed examine cooling effectiveness flow eeh suction side blade solving conservation equations ideal gas equation state turbulent compressible flow sufficiently high coolant mass flow rate flow eeh acts converging diverging nozzle choked nozzle throat resulting supersonic flow shock subsonic flow downstream location shock relative high temperature gas flow determines temperature distribution along blade surface analyzed detail following conditions varied coolant mass flow rate temperature difference gas coolant flow eeh location blade surface eeh inclination angle blade surface exit inlet area ratio eeh film cooling effectiveness calculated along surface blade results show increasing coolant flow rate improves effectiveness change temperature difference mainstream coolant slightly affects effectiveness inclination angle eeh pronounced effect film cooling corresponding effectiveness location eeh blade eeh slightly change effectiveness
network introduce non singular symmetric matrix called path intersection matrix provide new method computing ratio tree number lab obtained guab contracting new edge two distinct nodes quantities appear invariants various networks effective conductance electrical network ingredient information centrality social network review several examples networks path intersection matrices applied elsevier inc rights reserved
methodology proposed update mechanics based nonlinear finite element models civil structures subjected unknown input excitation approach allows jointly estimate unknown time invariant model parameters nonlinear model structure unknown time histories input excitations using spatially sparse output response measurements recorded earthquake event unscented kalman filter circumvents computation response sensitivities respect unknown model parameters unknown input excitations using deterministic sampling approach employed estimation tool use measurement data obtained arrays heterogeneous sensors including accelerometers displacement sensors strain gauges investigated based estimated model parameters input excitations updated nonlinear model interrogated detect localize classify assess damage structure numerically simulated response data three dimensional story bay steel frame structure six unknown model parameters subjected unknown directional horizontal seismic excitation three dimensional story bay reinforced concrete frame structure nine unknown model parameters subjected unknown directional horizontal seismic excitation used illustrate validate proposed methodology results validation studies show excellent performance robustness proposed algorithm jointly estimate unknown model parameters unknown input excitations elsevier ltd rights reserved
classification mental disorders advances towards disease model promoted national institute mental health nimh research domain criteria rdoc hope thorough neurobiological understanding mental illness may allow clinicians researchers determine treatment efficacy less diagnostic variability paradigm shift presented variety ethical issues considered development psychiatric drugs challenges limited informed consent practices industry funding placebo use consideration alternative research models quality research design also present ethical challenges development psychiatric drugs imperatives create valid sound research justify human time cost risk use limited resources must also considered clinical innovation consideration special populations also important aspects take account based breadth ethical concerns particularly important scientific questions regarding development psychiatric drugs answered collaboratively variety stakeholders field expands new ethical considerations raised increased focus genetic markers personalized medicine patient centered outcomes research tension funding suggest innovation trial design necessary better reflect practices clinical settings must emphasized focus expanding transparency consent processes regard suicidality care working special populations support goal developing sound psychiatric drug therapies authors published elsevier ltd
background smokers use cigarettes stop smoking substantial proportion try cigarettes later discontinue use concurrently smoking current dual users aim assess factors associated ongoing cigarette use discontinuation among smokers methods secondary analysis data currently smoking adults population based online survey conducted march multivariable logistic regression assessed motivation stop smoking among never cigarette users past triers weekly use current dual users multinomial logistic regression assessed associations cigarette use status motivation stop smoking reasons use age gender social grade heaviness smoking type first cigarette used reasons discontinuing use assessed results current dual users motivated stop smoking past users aor never users past triers motivation differ past users dual users less dependent cigarettes aor likely use cigarettes aid reduce smoking aor deal smoking restrictions aor past users smokers mostly discontinued cigarettes feel like smoking help cravings respondents wanted try conclusion among smokers ongoing use cigarettes associated reasons reducing smoking dealing smoking restrictions heightened motivation stop smoking lower dependence smoking author published elsevier ireland ltd
hashing based approximate nearest neighbors ann search drawn considerable attraction owing low memory storage hardware level logical computing doomed greatly applicable quantities large scale practical scenarios information retrieval computer vision natural language processing however existing hashing methods concentrate either images pairwise image texts labels short documents rarely utilize common sentences paper propose diversity regularized latent semantic match hashing drlsmh new multinlodal hashing method projects images sentences shared latent semantic spate label supervised semantic constraints proceed multimodal retrieval notably soft orthogonality induced novel regularizer preserve diverse hashing functions compact accurate representations kind regularization also benefits derivations closed form solutions proper relaxations iterative optimization framework extensive experiments two public datasets demonstrate advantages method state art baselines cross modal retrieval image query image image query text text query image tasks
aim study compare global functioning cognitive performance community sample young adults mood disorders versus community controls cross sectional study nested cohort study community sample data collected february june specifically mean five years first phase young adults invited participate evaluation mini international neuropsychiatric interview plus mini plus used diagnosis mood disorders functional assessment short test fast montreal cognitive assessment moca used assess global functioning cognitive performance respectively included subjects functional impairment greater subjects bipolar disorder compared community controls differences major depressive disorder community controls significant differences cognitive performance young adults mood disorders compared community controls functional impairment marker bipolar disorder young adults however gross cognitive impairment assessed screening test possibly cognition impaired advanced stages disorder
one important parameter feedback circuit characterization loop gain loop gain direct measurement easy task large majority practical situations signals appear system may form various complicated loops classic approach break loop calculate transfer around loop loop breaking difficult perform manual analysis impossible computer analysis using circuit simulator paper presents method based signal flow graph loop gain determination without breaking loop therefore without circuit determinant circuit operating conditions like biasing modification
introduction impact atrial natriuretic peptide anp value predicting paroxysmal atrial fibrillation paf ischemic stroke patients remains uncertain methods consecutive ischemic stroke patients median iqr years old females within hours onset retrospectively studied plasma anp brain natriuretic peptide bnp levels simultaneously measured admission patients evidence atrial fibrillation sinus rhythm group patients paf paf group patients chronic caf group investigated predicting factors paf focus anp bnp anp bnp ratio results anp value significantly higher paf group versus increased caf group versus paf groups similarly bnp value higher paf group versus increased caf group versus paf groups anp bnp ratio lower paf caf groups group versus multivariate analysis paf groups demonstrated age congestive heart failure anp bnp anp bnp ratio independent predictors detecting paf receiver operating characteristic curve analysis showed area curve similar anp bnp conclusions anp may clinically useful detecting paf ischemic stroke patients well bnp national stroke association published elsevier inc rights reserved
aim study identify existing gender roles greenhouse vegetable production antalya province turkey purpose conducted face face interviews owners vegetable producing greenhouses understand dominant household structures activity profiles information sources training needs access resources control resources intrahousehold income stream activity profiles reflected hours per day men women spent specific greenhouse production household tasks observed access control production resources well intrahousehold income streams two genders compared men women higher illiteracy rates lower levels education also overall heavier workloads despite similar workloads greenhouse productive activities difference resulting household reproductive activities carried mainly women women received agricultural information neighbors men obtained information chemical salespeople notably men received information agricultural extension service women women also less access control productive resources furthermore intrahousehold income streams selected households benefited men women study compared differences among three independent demographic variables age producers level education producers years experience farming women ability prepare family budget spend money without asking spouse purchase agricultural inputs select vegetables produce statistically significant links found women age ability manage family budget education level ability make purchase decisions years production experience ability select vegetables purchase results study provide evidence unequal social structure show efforts made increase women access control production resources including information extension service
many genes found pathogenic amyotrophic lateral sclerosis als among coiled coil helix coiled coil helix domain containing chchd reported play controversial role als examined coding region gene unrelated chinese sporadic als subjects familial als subjects healthy controls using polymerase chain reaction direct sequencing strategy two types variants identified one variant identified damaging one intron mutation previously reported chinese frontotemporal dementia patient study first report clinical heterogeneity specific mutations chchd als asian population report possible new mutation hotspot findings support major role chchd frontotemporal dementia amyotrophic lateral sclerosis disease spectrum stress importance mitochondrial abnormalities pathogenesis diseases asian cohorts elsevier inc rights reserved
investigate usefulness modifying scanning parameters based size specific dose estimate ssde breast dose reduction chest scanned women fixed volume dose index ctdivol mgy another fixed ssde mgy protocol protocol respectively protocol tube current calculated based patient habitus obtained scout images compared mean breast dose inter patient breast dose variability performed linear regression analysis breast dose body mass index bmi two protocols mean breast dose lower protocol protocol mgy mgy inter patient breast dose variability significantly lower protocol mgy mgy observed moderate negative correlation breast dose bmi protocol significant correlation protocol ssde based protocol achieved reduction breast dose inter patient breast dose variability aeuro cent scan parameters modified based pre scan ssde aeuro cent pre scan ssde useful breast dose reduction aeuro cent fixed ssde protocol reduced individual variations breast dose
introduction sustainability defined need preserve existing natural resources earth able continue provide resources future generations put simply sustainable system one survives persists costanza patten order ensure sustainability architectural building activity essential work field conducted accordance canons basic ecology addition members seek address certain cultural relational characteristics typify way live today architecture discipline combines technology art however advent sustainable architecture additional concepts fields ecology sociology philosophy incorporated yet fundamental problem meanings classical new concepts remain ambiguous significance shifting cultural evolution hence traditional vitruvian values architecture beauty structure utility longer obvious especially required think terms sustainability although question architecture matters answered variety ways glaeser contention century architecture matter ever world population concentrated cities result sustainability dwellings cities acquired undeniable importance two interacting forces influence populations one malthusian dynamic exponential growth environmental limits reached figure second darwinian dynamics innovation adaptation circumvent limits biological cultural evolution nekola reported specific manifestation two forces current society provide context establishes humans may develop sustainable relationships within finite planet figure consequently permanent indefinite growth impossible due physical biological imperatives finite world biologists architects constructors usually inhabit different worlds latter innovate deploy apply techno science based designs first study finite nature propose hypotheses gather evidence date little suggest copying nature purports advantages architects primarily fully autonomous buildings towns yet built according described malthusian darwinian dynamic two critical questions seek address paper essence sustainable dwelling principles adhered making dwelling sustainable words study aims elucidate essence sustainability green building design implementation
paper describes new approach methodology quantitative assessment fault tolerance multi phase traction electric motors complex parameter evaluating fault tolerance proposed use criterion degree fault tolerance approbation proposed method authors carried research obtained results practical application evaluating fault tolerance multi phase electric traction motors
software engineering knowledge intensive task software development organisations depend knowledge disposal develop high quality software become competitive software industry knowledge held employees organisation repositories routines processes important software development process literature review conducted investigate knowledge management practices benefits challenges software engineering four main areas research discovered software organisations software development process includes development teams testing development methodologies mitigating risk role fostering learning software development organisations benefits tools also discovered literature review software organisations teams create share acquire store share knowledge software development activities knowledge sharing storage reuse applied software development risk mitigation strong link practices learning software development found conclusion drawn literature review activities improved product quality delivery time execution tasks however gaps identified literature identify challenges software engineering state phases systems development lifecycle sdlc activities occur tell practices helped mitigate risk software development
economy one three pillars sustainability one parameters taken account many green building labels construction industry exist many methods evaluate project cost however none current methods takes account location economic flows final stakeholders benefit paper proposes new methodology tracing economic flows project classifying costs categories labour materials energy infrastructure taxes overhead two levels local regional aim facilitate economic decision making local authorities construction managers project investors make social dimension flows generalized impact project local society apparent applicability new methodology tested case studies observed analysis provides useful insights respect economic flows going direct labour overhead taxes well regarding spatialized distribution cost project
reduced physical function health related quality life common rheumatoid arthritis studies needed examine novel determinates reduced physical function study examines whether frailty state increased vulnerability stressors associated differences self reported physical function among adults adults longitudinal cohort participated study using established definition frailty individuals three following physical deficits classified frail body mass index low grip strength adjusted sex body mass index bmi measured handheld dynamometer severe fatigue measured multidimensional assessment fatigue slow walking speed adjusted sex height low physical activity measured international physical activity questionnaire individuals one two deficits classified pre frail deficits robust self reported physical function assessed health assessment questionnaire haq valued life activities difficulty scale regression analyses modeled associations frailty category haq valued life activities vla difficulty scores without controlling age sex disease duration reactive protein use oral steroids pain among adults frail compared robust associated worse vla score effects covariates held constant frail compared robust associated clinically meaningful differences self reported physical function among adults
background adolescents united states globally represent high risk population unintended pregnancy leads high social economic health costs access smartphone apps rapidly increasing among youth little known strategies apps employ prevent pregnancy among adolescents young adults guidelines best practices adolescent young adult pregnancy prevention mobile apps objective review developed preliminary evaluation framework assessment mobile apps adolescent young adult pregnancy prevention used framework assess available apps apple app store google play targeted adolescents young adults family planning pregnancy prevention support methods developed assessment rubric called mobile criteria adolescent pregnancy prevention mcapp data extraction using evidence based promising best practices literature mcapp comprises domains app characteristics user interface features adolescent pregnancy prevention best practices general sexual reproductive health srh features inclusion review apps advertised pregnancy prevention services explicitly mentioned youth english free systematically identified apple app store google play screening data extraction interrater reliability checks conducted reviewers app assessed facets mcapp checklist results search returned app descriptions apple app store google play screening inclusion criteria unique apps included analysis included apps targeted teens primarily developed countries common user interface features clinic health service locators app strengths included provision srh education description modern contraceptives use evidence based adolescent best practices gaps remain implementation majority adolescent best practices user interface features best practices teen pregnancy prevention operationalized mcapp commonly implemented best practice provision information use contraceptives prevent pregnancy followed provision accurate information pregnancy risk sexual behaviors information srh communication negotiation refusal skills use persuasive language around contraceptive use conclusions quality scope apps adolescent pregnancy prevention varies indicating developers researchers may need supportive framework mcapp help researchers developers consider mobile relevant evidence based best practices adolescent srh develop teen pregnancy prevention apps given novelty mobile approach research needed impact mcapp criteria via mobile channels adolescent health knowledge behaviors outcomes
introduction although social cognition skills biases well studied paranoia mind perception perceiving extent someone even possesses thinking feeling mind sought better characterise profile mind perception individuals paranoia methods examined links mind perception paranoia large subclinical sample participants completed measures paranoia schizotypy mind perception dispositional empathy assessments examined relationships one another well possibility mind perception partially mediates relationship paranoia empathy results analyses revealed increased paranoia linked less mind perception towards people distorted mind perception partially explained link paranoia perspective taking empathic concern conclusions paranoia psychopathology broadly understanding addressing distorted mind perception may one component restoring social functioning
study provide computerized graph structure synthesizing displaying data region ecosystem economic system applying mathematica based graph modeling create causal network synergistic impact mechanism among certain climate related factors computational approach identifies climate factor affects immediately strongly others important factors indicated use graph theoretical tools graph based approach computational aspects allow factor ranking according importance network numerically visually certain settlement types contribution provides quantitative estimates impacts adaptation potentials five potential effects climate change migration flooding landslides fire air water pollution human health energy water resources play substantial role synergistic impact mechanism using graph visualization techniques structure synergistic impact mechanism selfevident specifically graph layouts created detect causal relationships synergistic mechanism study influential factor synergistic mechanism iii classify factor roles based degree impact within coping mechanism highlighting graph elements let information policy implications stand economic society australia queensland published elsevier rights reserved
precision agriculture represents new paradigm modern agriculture objective increasing productivity economic efficiency joined arising objective environmental concern precision agriculture techniques require better understanding crop soil needs use precise machinery take account spatial temporal variability across fields terms goal study design development evaluation universal platform control conventional disc fertilizer spreader thus able manage amount fertilizer specific field calibration necessary determine spreader settings given type fertilizer components hardware modules control system disks interaction sections control system etc capable automating actions performed operation spreader developed control system developed based open source low cost microcontroller board arduino could adapted easily spreader model firmware capable control hardware components installed board field tests provided investigate proper functioning response time approx sec control system achieve automate process varying fertilizer dose noted preliminary results utilization prototype essential part variable input application may found economic reduction fertilizer operation environmental impact allows control nitrogen fertilizer fields techniques definitely significant modern agriculture production systems
objective explore potential relationships hiv highly active anti retroviral therapy haart hypertensive disorders pregnancy hdp methods retrospective secondary analysis maternal deaths data saving mothers report south africa incidence hiv infection amongst individuals died owing hdp determined comparisons made based hiv status use haart results among maternal deaths recorded saving mothers report lower risk maternal deaths due hdp observed among women hiv infections compared women hiv relative risk confidence interval reduced odds death due hdp recorded among women aids undergoing haart compared women hiv require treatment notably among women aids greater risk death due hdp demonstrated among received haart compared conclusion hiv aids associated decreased risk hdp primary cause death use haart increased risk
real time monitoring extracellular neurotransmitter concentration offers great benefits diagnosis treatment neurological disorders diseases paper presents study design results miniaturized wireless optical neurotransmitter sensor mwons real time monitoring brain dopamine concentration mwons based fluorescent sensing principles comprises microspectrometer unit microcontroller data acquisition bluetooth wireless network real time monitoring mwons custom designed application software controls operation parameters excitation light sources data acquisition signal processing mwons successfully demonstrated measurement capability limit detection nanomole dopamine concentration high selectivity ascorbic acid uric acid
members independent active baby boom generation entering retirement years may put clinical nurse specialists cns greater demand ever educators consultants researchers case managers community based educational programming promote health monitor manage chronic health conditions elders recognized method cns meet growing demands application utilization baltes baltes theoretical model selective optimization compensation soc senior health programming holds promise cnss assume integral roles optimizing health promotion self actualization community living elders senior centers serve older adults want stay active involved others age current including learning promote health cns readily infuse soc model planning organizing health programming older adults senior centers turn aid elders maintaining independent functioning autonomy quality life detailed template developing theory driven programming example program focused nutrition provided finally variety topics additional soc guided program development presented
rainwater harvesting rwh used often today water supply stormwater management green infrastructure recent years gis urban water engineering gained attention due lower lifecycle costs implementation operation phases rather traditional gray approaches research described present paper compared implementation rwh systems gray approaches previously designed part long term control plan ltcp combined sewer overflow cso control toledo ohio rwh scenarios study defined based different system capacities release policies combined gray green scenarios analyzed according hydrologic performance cost study employed long term continuous hydrologic hydraulic simulations well lifecycle cost lcc analysis techniques results showed greening ltcp via rwh could improve lifecycle cost effectiveness captured rainwater considered supply toilet flushing water demand buildings american society civil engineers
introduction computer programming become mainstream last years countries around world making coding part curriculum nevertheless lack empirical studies investigate learning program early age affects school subjects regard paper compares three quasi experimental research designs conducted three different schools students grade order assess impact introducing programming scratch different stages several subjects grade experimental groups working coding activities showed statistically significant improvement terms academic performance case grade classroom notable disparity also found regarding subject programming activities included social studies effect size double mathematics
homeless patients high rates visual impairment lower rates glycemic control housed patients although diabetic retinopathy common cause new visual impairment legal blindness developed world little known differential risk factors rates homeless versus housed populations study aimed compare rates homeless housed patients diabetes greater los angeles veterans affairs health care system gla identify clinical psychosocial predictors rates performed secondary database analyses veterans diabetes received care gla october september described differences demographic clinical psychosocial characteristics associated homeless versus housed patients created logistic regression model identify independent predictors found diabetic veterans homeless compared housed higher rates substance use disorders mental health diagnoses primary care mental health visits likely diabetic retinopathy eye screening according guidelines multiple logistic regression modeling predicting revealed independently associated homeless housed older age retinal screening anemia higher systolic blood pressure insulin use microalbuminuria higher hbac homeless diabetic veterans lower rates may due gla tailored intensive psychological medical resources homeless veteran patients
background driven range sustainability challenges climate change resource depletion expanding populations circular bioeconomy emerging expected evolve progressively coming decades south africa along brics countries brazil russia india china represents emerging bioeconomy contributes significantly global sugar market research south africa used case study demonstrate sustainable design future biorefineries annexed existing sugar industry detailed techno economic evaluation life cycle assessment lca applied model alternative routes converting sugarcane residues bagasse trash selected biofuel biochemicals ethanol ethanol lactic acid ethanol furfural butanol methanol fischer tropsch synthesis production surplus electricity energy self sufficient biorefinery system results economic assessment indicated methanol synthesis internal rate return irr ethanol lactic acid production met minimum investment criteria latter lowest sensitivity market price amongst scenarios lca results demonstrated sugarcane cultivation significant contributor environmental impacts scenarios furfural production scenario key step biphasic process tetrahydrofuran solvent significant contribution conclusion overall thermochemical routes presented environmental advantages biochemical pathways impact categories except acidification eutrophication investigated scenarios furfural production delivered inferior environmental performance methanol production performed best due low reagent consumption combined techno economic environmental assessments identified performance limiting steps biorefinery design sugarcane industry highlighted technology development opportunities circular bioeconomy context
work presents noninvasive methodology obtain biomedical thermal imaging provide relevant information may assist diagnosis emotions biomedical thermal images facial expressions subjects captured experiencing joy disgust anger fear sadness analysis thermograms carried thermal value intensity value regions interest obtained image processing techniques allow differentiate subject background subject centers region interest obtained order get region face subject thermal analysis biomarker region interest obtained biomarkers diagnose emotion takes place subject tends react differently stimuli self calibration phase proposed function thermal trend subject order make decision five emotions correctly diagnosed top hierarchical classifier final result smart thermal system diagnose emotions obtained tested twenty five subjects thermograms results test successful elsevier rights reserved
posttraumatic stress disorder ptsd psychiatric disorder repetitive transcranial magnetic stimulation rtms found effective treating ptsd whether different frequencies different effects remains controversial conducted systematic review meta analysis address question searched literature studies written english chinese electronic databases databases inception august additional articles identified reference lists identified studies personal reference collections eighteen articles included suitable meta analysis combined sample size active rtms groups sham controlled groups low frequency rtms resulted significant reduction ptsd total score depression score ptsd total score pooled smd depression pooled smd high frequency rtms showed following results ptsd total score pooled smd experiencing pooled smd avoidance pooled smd hyperarousal pooled smd depression pooled smd anxiety pooled smd therefore rtms alleviate ptsd symptoms although evidence extremely limited rtms reduce overall ptsd depression symptoms rtms improve main related symptoms ptsd however additional research needed substantiate findings elsevier ltd rights reserved
incremental sheet forming isf emerged one rapid prototyping processes forming shaped products design data without much need human tool intervention past studies show extensive focus paid analysis surface roughness clamped accuracy energy consumption terms machine standby positioning energy little focus paid deformation energy unclamped accuracy context system identification based methods play vital role determining evaluating hidden relationships inputs tool diameter wall angle sheet thickness step two characteristics namely deformation energy unclamped accuracy present work proposes comprehensive study based feedback evolutionary system identification esi approach predictive evaluation multiresponse characteristics validation robustness models done based statistical error metrics cross validation new complexity metrics hypothesis tests furthermore model analysis based parametric sensitivity procedures resulted plots measure nature two characteristics respect four inputs found sheet thickness wall angle influence deformation energy unclamped geometrical accuracy respectively findings analysis useful monitoring deformation energy thus promoting greener environment
background parkinson disease progressive neurodegenerative disorder results widespread loss select classes neurons throughout nervous system pathological hallmarks parkinson disease lewy bodies neurites alpha synuclein fibrils major component alpha synuclein aggregation reported gut parkinson disease patients even decade motor symptoms similar observations made animal models disease however unlike central nervous system nature alpha synuclein species form aggregates classes neurons affected gut unclear previously reported selective expression alpha synuclein cholinergic neurons gut comp neurol suggesting may particularly vulnerable degeneration parkinson disease methods study used immunohistochemistry detect alpha synuclein oligomers fibrils via conformation specific antibodies rotenone treatment prolonged exposure high vivo segments guinea pig ileum maintained organotypic culture key results rotenone prolonged raising caused accumulation alpha synuclein fibrils axons cholinergic enteric neurons took place time case rotenone concentration dependent manner rotenone also caused selective necrosis indicated increased cellular autofluorescence cholinergic enteric neurons labeled chat immunoreactivity also concentration dependent manner conclusions inferences knowledge first report rotenone causing selective loss neurochemical class enteric nervous system cholinergic enteric neurons may particularly susceptible lewy pathology degeneration parkinson disease
study analyzes temperamental social correlates month olds instrumental helping handing reach objects comforting alleviating experimenter distress reach helping basic type prosocial behavior associated social temperamental variables comforting associated maternal responsible parenting day care attendance temperamental fear accounting total variance corresponding regression model data present study suggest simple instrumental helping seems robust developmental phenomenon comforting associated specific social experiences child temperament constitute interindividual differences thereby help explain domain specific development prosociality elsevier inc rights reserved
biodiesel processor developed production biodiesel non edible oil jatropha karanj newly developed biodiesel processor suitable farmers village level biodiesel production biodiesel processor capable producing biodiesel per batch reaction temperature degrees biodiesel produced raw jatropha karanj oil blends diesel tested power generation kva diesel engine generator set fuel properties namely kinematic viscosity specific gravity found within limits bureau indian standards specifications overall efficiency generator loading condition jatropha karanj biodiesel blended fuel recorded range respectively overall efficiency generator loading conditions improved jatropha karanj biodiesel blends found range respectively biodiesel blends pure biodiesel karanj produced power maximum overall efficiency recorded compared diesel fueled generator overall efficiency jatropha biodiesel blended fuel found less diesel fueled generator biodiesel processor based alkali catalyzed transesterification process used quality biodiesel production edible non edible vegetable oils processor integrated rural energy system domestic small scale industrial unit biodiesel production
background studies whether occurrence psychotic experiences pes depression confers pronounced decrement health status function compared depression alone scarce general adult population method data adults aged years world health survey analysed using world mental health survey version composite international diagnostic interview cidi depression past months categorized four groups depressive episode brief depressive episode subsyndromal depression depression past month psychotic symptoms assessed using four questions positive symptoms cidi health status across seven domains cognition interpersonal activities sleep energy self care mobility pain discomfort vision interviewer rated presence mental health problem assessed multivariable logistic linear regression analyses performed assess associations results compared depression individuals depression higher odds reporting least one seen across levels depression severity subsyndromal depression odds ratio confidence interval brief depressive episode depressive episode coexisting pes depression associated higher risk observable illness behavior significant decline health status cognition interpersonal activities sleep energy domains compared depression alone conclusions coexistence depression pes associated severe social cognitive sleep disturbances outwardly apparent illness behavior detecting occurrence may important treatment planning
authentication user online banking major issue recent days transactions carried using insecure internet channel modern communication medium much exposed various threats one time password otp used prove one identity wireless channel otp sent user registered mobile number sms commonly used technique user authentication otp sms sent normally plain text vulnerable various attacks along communication channel solve problem research aims provide technique transform otp using lightweight cryptography hide cipher text using text steganography send stego text sms user mobile personal identification number pin supplied bank registration used ciphering user needs know pin read otp user proceed business transaction authentication process provides end end encryption otp sms
aim concept coping central recent models psychosis aim present paper explore whether specific coping styles relate certain stages disorder methods thirty nine clients clinical high risk chr first episode psychosis clients first episode psychosis clients multiple episode psychosis completed stress coping questionnaire questionnaire consists items defining one overall positive coping scale three subscales one negative coping scale analyses variance group subject factor coping behaviour within subject factor used identify different coping patterns results level subscales group differences could detected analysis variance revealed slightly different patterns chr clients used significantly negative positive coping styles followed patients multiple episode psychosis firstepisode patients likely use negative well positive coping across stages illness stress control significantly preferred compared positive coping styles distraction devaluation pattern especially pronounced risk clients patients multiple episode psychosis whereas patients first episode psychosis likely use devaluation well distraction conclusions overall coping styles similar across different stages psychosis however risk persons presented especially pronounced negative coping small range strategies indicating specific need psychosocial support stage disorder
work excited state intramolecular single double proton transfer mechanisms bis benzoxazol thiophene diol investigated using time dependent density functional theory tddft method first time calculations showed intramolecular hydrogen bond center dot center dot center dot strengthened excited state provides driving force effectively facilitate proton transfer process constructed potential energy surface excited state demonstrated double proton transfer reaction occurs readily dynamics thermodynamics aspects implemented simultaneous double proton transfer successive single transfers furthermore assignments multiple fluorescence bands experiment confirmed fluorescence spectral simulation calculated emission spectra indicated experimental fluorescence maxima attributed normal stokes shifted emission large stokes shifted fluorescence peaks originates double proton transfer phototautomer emission experimentally observed shoulder peak similar results excited state single proton transfer tautomer elsevier ltd rights reserved
powerful instrument modelling analysing simulating dynamic systems petri nets used many times past solve software engineering problems model different aspects information system however none research attempts succeeded modelling complete information system behaviour formal executable way time field requirement specification modelling information systems usual find object oriented methodologies uml instead formal methods petri nets paper propose model based extension petri nets creating formal static dynamic models information systems proposed model designed executable replacement uml dynamic diagrams modelling static structure system still suggest using methods proposed petri nets extension provides complete integration static elements petri nets used dynamic model main contribution proposed petri nets extension get formal model unlike known formal models directly completely executable precisely created model petri net represents real information system functionalities moreover created case tool allows modelling execution system using proposed model
development processes software safety critical complex aircraft systems example flight control systems demanding context aircraft certification strict process guidelines objectives radio technical commission aeronautics according development assurance level software complied efficiency compliance important goals defining processes requirements approach gain efficiency reuse models function design code generation use qualified tools control engineering matlab simulink stateflow widely used tools build models code generator embedded coder mathworks tool chain available qualifiable tool hence common avionics domain use scade suite qualifiable code generator kcg software design enable reuse simulink stateflow models code generation kcg necessary translate scade project certt fbw feasibility study automatic translation simulink stateflow scade using scade suite gateway simulink performed existing control law model automatic flight control system used example due size functionality demanding suitable example enable translation simulink stateflow models modeling guidelines derived project mcas motivate approach show used effectively automatic guideline checking model repair tool chain translation configuration management processes presented briefly introducing example model selection guidelines repair algorithms shown helped increase translatability example
growth beauty industry makes business competition become dynamic competitive clinic skin care existing attempt maintain customer repurchase intention repurchase intention important business continuance company aspect create repurchase intention customer satisfaction right strategy achieve customer satisfaction make brand experience customer research aims determine effect brand experience customer satisfaction impact toward repurchase intention clinic skin care customers bandung type research used verified descriptive method conducted explanatory survey simple random sampling numbers respondent participants data analysis technique conducted research path analysis spss computer software based whole result test score obtained path analysis score table means significant effect brand experience customer satisfaction impact toward repurchase intention
malicious software activities become clandestine making challenging detect existing security solutions rely heavily recognition known code behavior signatures incapable detecting new maiware patterns propose discover triggering relations network requests leverage structural information identify stealthy malware activities attributed legitimate cause triggering relation defined temporal causal relationship two events design compare rule learning based methods infer triggering relations network data introduce user intention based security policy pinpointing stealthy malware activities based triggering relation graph extensively evaluate solution darpa dataset real world network traffic results indicate dependence analysis successfully detects various maiware activities including spyware data exfiltrating malware dns bots hosts good scalability large datasets learning based method achieves better classification accuracy rule based one significance traffic reasoning approach ability detect new stealthy malware activities authors published elsevier ltd
alcohol dependent patients ads known encounter severe interpersonal problems nonverbal communication skills important development healthy relationships present study aimed explore emotional facial expression efe recognition posed spontaneous efe expressivity male ads divided two groups according cloninger typology impact interpersonal relationship quality potential nonverbal deficits twenty type ads twenty one type ads twenty control participants took part efe recognition task efe expressivity task considered personal emotional events spontaneous expressivity efe response photo word cue posed expressivity coding based judges ratings participants emotional facial expressions participants additionally completed questionnaire interpersonal relationship quality difference three groups emerged efe recognition task type ads showed heightened deficits compared type ads efe expressivity judges perceived less accurate posed efe response cue word less intense positive spontaneous efe type ads compared control participants addition type ads reported relationship difficulties compared type ads control participants interpersonal relationship difficulties related efe expressivity deficits iis study underlines important differences interpersonal functioning subtypes
objective previous studies indicated association chiari malformation type small posterior fossa studies limited quantitative methods recent studies utilizing methodologies time intensive manual segmentation authors sought develop automated tool calculate posterior fossa volume correlate changes decompression surgical outcomes methods semiautomated segmentation program developed used compare pre postoperative volumes posterior cranial fossa pcf csf spaces cisterna magna prepontine cistern fourth ventricle cohort pediatric patients volume changes correlated postoperative symptomatic improvements headache syrinx tonsillar descent cervicomedullary kinking overall surgical success results forty two pediatric patients included study mean percentage increase pcf volume significantly greater patients showed clinical improvement versus improvement headache tonsillar descent overall clinical success associated larger postoperative pcf volume increase clinical improvements also significantly associated larger increase volume cisterna magna increase caudal portion posterior fossa volume also larger patients showed improvement syrinx cervicomedullary kinking conclusions greater increase postoperative pcf volume specifically increase cisterna magna volume associated greater likelihood clinical improvements headache tonsillar descent patients larger increases caudal portion posterior fossa volume also associated greater likelihood improvement syrinx cervicomedullary kinking
individual placement support ips evidence based employment model people severe mental illness evaluated clients enrolled substance abuse treatment programs study evaluated effectiveness ips people opioid use disorders enrolled opioid treatment program within randomized controlled experiment patients receiving methadone maintenance therapy assigned either ips month waitlist waitlist group received ips months primary outcome assessed year compared attainment job ips condition waitlist comparison group first months enrollment active ips participants gained competitive employment compared waitlist participant months enrollment ips participants gained competitive employment compared waitlist participants conclude ips holds promise employment intervention people opioid use disorders methadone maintenance treatment larger trials longer follow needed
introduction aggression one leading clinical characteristics antisocial personality disorder apd studies aiming clarify control biological basis aggression ongoing thyroid hormones indicated play role development aggression aim study examine level aggression serum thyroid hormone sample apd make contributions field current findings methods sample consisted subjects diagnosis apd subjects control group structured clinical interview dsm axis scid used diagnosis buss perry aggression questionnaire administered based criminal patterns apd group divided two subgroups criminal noncriminal apd groups day interview one night fasting blood collected subjects thyroid function tests biochemical analyses related confounding variables also administered study group control group compared terms aggression scores thyroid hormone levels results mean score free level criminal apd group found significantly higher noncriminal apd group apd subjects higher free levels also higher aggression scores noncriminal apd group serum free levels increased also increment aggression scores however criminal apd group significant correlation thyroid hormone levels aggression conclusion findings study indicated criminal noncriminal apd groups actually show different properties
psoriatic arthritis psa accounts around referrals early arthritis clinic presents significant diagnostic management challenge early diagnosis important prevent long term functional disability ensure optimal management arthritis key comorbidities rheumatologist perspective differential diagnosis includes rheumatoid arthritis gout inflammatory arthritides diagnosed essential assess disease fully including arthritis enthesitis dactylitis skin nail disease axial involvement using information appropriate treatment planned using therapies effective treating relevant domains disease despite poor data traditional disease modifying anti rheumatic drugs commonly used effective observational studies following tumour necrosis factor inhibitors proven excellent efficacy multiple domains psa new biologics available development improve treatment options people refractory psa
united states judicial system response violence intimate partners intimate partner violence ipv typically mandates adjudicated perpetrators complete batterer intervention program bip social science data found programs whole minimally effective reducing rates ipv authors examined social science literature characteristics efficacy bips studies considered including sweeping recently conducted survey bip directors across united states canada results review indicate limitations bips due large part limitations current state standards regulating programs furthermore standards grounded body empirical research evidence best practices authors considerable expertise area domestic violence perpetrator treatment conducted exhaustive investigation following key intervention areas overall effectiveness bips length treatment length group sessions number group participants number facilitators group format curriculum assessment protocol instruments victim contact modality treatment differential treatment working female perpetrators working perpetrators racial ethnic minority groups working lesbian gay bisexual transgender lgbt perpetrators perpetrator treatment practitioner client relationships required practitioner education training recommendations evidence based national bip standards made based findings review
increase stroke incidence occurs women decline estrogen levels following menopause ischemic damage may recur especially soon first insult occurred evaluated effects estrogen phytoestrogen treatment vitro recurrent stroke model using neuronal cell line cells treated beta estradiol genistein beginning first two oxygen glucose deprivation reoxygenation ogd cycles second ogd deterioration components electron transport chain cytochrome oxidase subunit subsequent increase reactive oxygen species ros production accordingly also increase apoptotic phenomena demonstrated poly adp ribose polymerase cleavage caspase activity annexin levels recurrent ischemic injury also raised hypoxia inducible factor alpha glucose transporter levels well ratio lipidated cytosolic forms microtubule associated protein light chain found positive effect estradiol genistein treatment partially preserving impaired cell viability recurrent ischemic injury however positive effect seem mediated neither blocking apoptosis processes decreasing ros production work contribute better understanding molecular mechanisms triggered recurrent ischemic damage neuronal cells therefore could help development effective treatment minimize consequences pathology
study proposes high performance voltage controller design employs capacitor current control model single phase stand alone inverters single phase stand alone inverter analyzed via modeling used design controller design methodology proposed maximize bandwidth feedback controller subsequently compensate problems caused bandwidth limitations controller error transfer function includes feedback controller derived stability repetitive control scheme evaluated using error transfer function digital repetitive controller implemented simulation experimental results show performance proposed controller high single phase stand alone inverter prototype
paper adopting new approach investigate capabilities pathological mirror elements ideal representation active building blocks shows voltage mirror current mirror basic pathological elements descriptions floating mirror elements nodal admittance matrix nam using infinity variables derived descriptions nullator norator using infinity variables nam shown represent special cases derived descriptions floating respectively hence new representations nullator norator terms floating respectively obtained systematic procedure derivation pathological configurations ideally represent various analog signal processing properties featured active building blocks presented systematic approach became plausible virtue versatility offered nam descriptions floating mirror elements novel pathological configurations ideally describing popular signal processing properties involve differential multiple single ended signals like conversion differential single ended voltages differential voltage conveying current differencing differential current conveying inverting current replication derived systematically using procedure resulting pathological configurations shown constructed mainly using mirror elements hence capabilities mirrors basic pathological elements demonstrated pathological representations active building blocks using derived pathological sections presented application examples copyright john wiley sons ltd
objectives define different characteristics transdermal oxybutynin treatment overactive bladder adults know barriers use drug establish proposals minimize barriers methods local sessions held urologists country divided sessions moderated brainstorming technique led external consultant results experts believe tolerability clinical efficacy important attributes choose formulation lack scientific publications least valued opinions based clinical experience scientific publications without establishing comparison treatment options main barriers would administrative obstacles difficulty use lack rejection transdermal administration patient actions proposed correct significant barriers better training specialists urology specialties patients creating informative materials reinforce health education managing patches generating greater volume scientific evidence support use overactive bladder clearly identifying profile patients benefit therapeutic strategy conclusions although oxybutynin standard treatment overactive bladder recent years conclusion working group new transdermal formulation offers better tolerated alternative patients therefore necessary tools generate evidence implemented increase proper use among specialists patients
paper introduced autonomous robots would benefit improvements haptic intelligence overview telerobotics systems real world want robots help perform tasks remote environment paper also accentuates synergy human operator robot various applications healthcare medicines entertainment education graphic arts industry well space aim design construct robotic arm cooperation haptic feedback processes conceptualization design assembly final coding required complete tasks ranging needs assessment static dynamic load analyses design manufacturing machining troubleshooting finally microcontroller coding name
breast cancer important cause death women globally though improved survival due developments screening techniques initial diagnosis advances treatments numerous factors contributed progression breast cancer inflammation significant factor involved inflammatory process helper cells cells exceptional role many inflammatory diseases like psoriasis rheumatoid arthritis breast cancer production proinflammatory cytokine collected indication recommends possible relevance chronic inflammation cancer tumorigenesis appears cytokine stimulate tumorigenesis breast tumor cells family consist protein members among ilb receptor ilrb signaling pathway plays key role development progression breast cancer targeting signaling pathway specific downstream mediators chemotherapy drug small interfering rna interference potentially novel therapeutic pathway inhibition disease comprehensive review details recognition activity signaling roles ilb ilrb breast cancer caused determination new therapeutic mechanisms purpose introduction system regulation signaling pathway elsevier masson sas rights reserved
paper presents approach improving process optimal design permanent magnet motors finite element method fem combined dynamic dual response surface model dual rsm proposed compute objective function fem employed basic tool computation objective function order build dual rsm model radial basis function moving least square approximation employed results obtained dual rsm model dynamically compared together preset goodness fit determines whether accuracies dual rsm high enough replace fem computation strategy makes fem computation always necessary sample points optimization process ensures accuracy solution purpose showing effectiveness proposed optimization methodology optimal design process dual excited synchronous motor taken example paper
past research finds people behave though particular qualities specific strongly valenced individuals rub objects people thus value sweater worn george clooney disgusted one worn hitler hypothesized social traces generic humans also adhere objects increasing value experiments found simply marking consumer products mugs giftwrap made generic strangers people using machines machines run people increased perceived value experiment demonstrated effect mediated thoughts attention object received people turn led people see object possessing positive social qualities friendly increasing valuation results suggest generic humans perceived positively possessing warm social qualities rub adhere everyday objects increasing value
paper show method reduce complexity demodulation passive multiple input multiple output mimo scheme proposed improve transmission rate passive radio frequency identification rfid order reduce complexity maximum likelihood detection mld analog signal processing used decouple streams using beam forming receiver basis simulation shown proposed demodulation method improve complexity mld slight deterioration ber also shown proposed method effective especially reducing complexity passive mimo demodulation advantage becomes remarkable proportion number tag antennas
developing country like bangladesh demand electrical energy higher available production present electricity supply deficiency day total supply day within demand day reason power failure become acute problem country solve energy crisis important found alternative approaches recently tidal power becomes important researchable topic world especially countries placed near sea ocean bangladesh situated degrees degrees north latitude degrees degrees east longitude area coastal line along bay bengal bangladesh long coastal line along bay bengal tidal energy technology used one major reliable energy resource paper efficient tidal energy site proposed based analysis technical well market data data collected bangladesh navy different tidal current data chart finally based tidal current condition one efficient site matlab simulink simulation result shown proposed suitable electrical generator
utilizing signal flow graphs teaching linear circuits discussed paper graph features stated make inclusion existing curriculum easy graphs presented seem optimum quick hand paper analysis circuits containing ideal opamps vcvss ota elements
permanent magnet synchronous machines pmsm depending machine application different types permanent magnets used common pms ferrite magnets neodymium iron boron magnets ndfeb samarium cobalt magnets smco selection suitable magnet particular machine design depends magnet properties remanence conductivity mechanical rigidity losses demagnetization characteristics usually possibility hysteresis losses materials neglected paper however demonstrated possible hysteresis losses evaluated machine design shown measurements simulations machine designs hysteresis losses ndfeb smco ferrite magnets source significant additional losses may lead high operating temperatures reduction machine efficiency
four studies specify moral evaluations self regulate behavior aimed restoring moral reputation propose people care evaluations moral immoral perceived consequential types information therefore people inclined restore image negatively evaluated terms morality rather competence studies revealed moral information perceived enduring impact one reputation strongly related anticipate intra group respect self views competence sociability information perceived pervasiveness moral competence evaluations mediated intentions justify explain one behavior study study finally showed seen lacking morality elicited threat coping responses induced subsequent tendencies repair one moral reputation
abstract one critical task wind turbine shaft torsional vibration study involves modeling wind turbine power grid focus mechanical rotational system wind turbine article provides three mass shaft model upon one wind turbine infinite bus model developed model based small signal stability analysis used study wind turbine shaft torsional vibration reason article concentrates union model stall wind turbine power grid small signal stability model includes mechanical system electrical system data turbine blades shaft well electrical generator given allow replication model entirety component blocks wind turbine power grid modeled separately one easily expand modify model simulate variable speed wind turbines multi turbines system suit needs followed case study explains small signal stability model used study wind turbine shaft torsional vibration issues results obtained case study show model performs expected
paper presents methodology generate manufacturing routes operations using rules precedence provide logical approach dimensioning chaining rules precedence order prioritize knowledge various manufacturing processes taking account theories machining forging assembly heat treatments also utilizes theories accumulation tolerance process capability others proposed methodology requires development manufacturing data bases manufacturing process tolerances capabilities deviations machine tool cutting tool fixture device work piece rules precedence make viable generation manufacturing routings operations usage structured knowledge instead tacit one approach allows structured development manufacturing routes deployed engineers working areas manufacturing engineering
systematic unified method using signal graph sfg technique presented analyzing pulsewidth modulated pwm switch mode power converters smpc operating continuous conduction mode ccm loop gains single multiloop systems reviewed sfg converter generated perturbed state space averaged ssa equations characteristic polynomial system computed grouping terms associated gain error amplifier numerator unique definition system loop gain introduced locations breaking loop discussed system loop gains voltage current programming converters either trailing leading edge modulation derived shown smpc loop gain measured analog injection method system loop gain determines stability converter
purpose proof concept pilot study purpose determine correlations gut microbiota composition alterations cardiorespiratory fitness psychosocial outcomes among post primary treatment breast cancer survivors bcs methods composition gut microbiota bcs assessed baseline end months using illumina miseq dna sequencing rrna gene gut microbiota composition analyzed using qiime bioinformatics software represented diversity metrics taxa analyses cardiorespiratory fitness fatigue anxiety depression sleep dysfunction assessed via submaximal treadmill test fatigue symptom inventory hospital anxiety depression scale pittsburgh sleep quality index respectively results increased fatigue interference bcs associated increased mean within sample shannon diversity organism richness evenness weighted unifrac analysis shifts taxa relative abundance revealed significant differences sample beta diversity changes fatigue interference anxiety trend observed fatigue intensity sleep dysfunction unweighted unifrac analysis shifts taxa types found significant beta diversity differences cardiorespiratory fitness prior false discovery correction fdr changes fitness fatigue anxiety sleep dysfunction associated frequency certain gut bacteria genera faecalibacterium prevotella bacteroides conclusions correlations may exist alterations gut microbiota composition longitudinal changes cardiorespiratory fitness fatigue anxiety bcs research examining role microbiota gut brain axis exercise induced effects psychosocial outcomes bcs warranted
passive moderator cooling system pmcs advanced heavy water reactor designed remove heat moderator passively case extended station black condition sbo hot heavy water moderator inside calandria rises upward due buoyancy cooled shell tube heat exchanger located within loop returns back calandria completing natural circulation loop heat exchanger turn cooled water gravity driven water pool gdwp forming second loop coupled natural circulation loop system provides sufficient cooling prevent increase moderator temperature inside calandria vessel beyond safe limits sbo feasibility system assessed implemented reactor thus scaled test facility set simulate thermal hydraulic characteristics pmcs set time varying power experiments performed capture flow initiation rest phenomena multidimensional natural convection flow coupled natural circulation system next experimental geometry simulated using three dimensional computational fluid dynamics code openfoam predicted temperature flow distribution inside system cfd results agree well experimental data within flow initiation phenomena shows initial flow generated recirculates within calandria similar flow able come calandria experiments show time lag starting primary secondary loop circulation work demonstrates experimental computational capability understand design effective passive moderator cooling system elsevier ltd rights reserved
recent years fused deposition modelling fdm gaining popularity due distinct advantages terms cost effectiveness lower build times flexibility compared printing processes sls process use kind high intensity laser power build functional parts cad models hence makes process much simpler cheaper adaptable past studies reveal productivity fdm process increased effectively controlling process parameters layer thickness part orientation extrusion temperature regard many authors investigated optimal parameter settings improving part strength surface finish wear fatigue properties fdm made prototypes however warping performance behavior got recent attention due complex heat transfer mechanism involved process experimental investigations necessary understand deformation behavior prototypes addition quantification optimization warp deformation along dimensional error poses challenging multi objective optimization problem therefore work proposes evolutionary system identification approach explicitly quantify warp deformation dimensional error based four inputs line width compensation extrusion velocity filling velocity layer thickness fdm prototypes two models performance analysis comprising error metrics evaluation cross validation hypothesis tests performed validate robustness analysis concluded layer thickness extrusion velocity influence warp deformation filling velocity line width compensation influences dimensional error
research human aggression progressed point unifying framework needed major domain limited theories aggression include cognitive neoassociation social learning social interaction script excitation transfer theories using general aggression model gam review posits cognition affect arousal mediate effects situational personological variables aggression review also organizes recent theories development persistence aggressive personality personality conceptualized set stable knowledge structures individuals use interpret events social world guide behavior addition organizing already known human aggression review using gam framework also serves heuristic function suggesting research needed fill theoretical gaps used create test interventions reducing aggression
examined selective autophagy ubiquitinated protein aggregates sporadic inclusion body myositis ibm patients form autophagy requires phosphorylation serine sqstm bind lys linked ubiquitin binding ubiquitinated protein conjugates muscle biopsy specimens ibm patients compared distribution ser phosphorylated lys linked ubiquitin double colour immunofluorescence microscopy lys linked ubiquitin colocalised aggregates mean respectively although positive deposits arid lys linked ubiquitin always observed within aggregates often showed dissociated distribution also found fibres containing small numerous positive dots negative three markers also observed myositis controls results indicate lys linked ubiquitin ibm join perform selective autophagy could induced cellular stresses types myositis however ibm compromised binding pubiquitinated protein complex could stop autophagy process initial stages causes formation aggregates oligomers lys ubiquitinated proteins elsevier rights reserved
partial match queries constitute basic type associative queries multidimensional data structures trees quadtrees given query coordinates specified left unspecified partial match search returns subset data points data structure match given query data points whenever exists wealth results cost partial match searches many different multidimensional data structures results deal random queries recently papers begun investigate cost partial match queries fixed query paper represents new contribution direction giving detailed asymptotic estimate expected cost given fixed query previous results cost partial matches fixed query ones presented deeper understanding emerging uncovering following functional shape lower order terms throughout work many multidimensional data structures differ exponent constant dependent data structures whole pattern specified unspecified coordinates well although tempting conjecture functional shape universal shown experimentally seems true variant trees called squarish trees
aim study investigate association physical activity objective heart rate variability hrv based stress recovery subjective stress longitudinal setting working age participants women men overweight body mass index psychologically distressed points general health questionnaire objective stress recovery based hrv recordings work days subjective stress assessed perceived stress scale level questionnaire data collected three time points baseline weeks post intervention week follow adopted latent growth model investigate initial level change objective stress recovery subjective stress three measurement time points results showed initial levels objective stress recovery associated change subjective stress results persisted adjustment intervention group present results suggest high objectively assessed low stress good recovery positive effects changes subjective stress long term
designed physical chemistry laboratory introduce upper division students electrochemistry concepts including mixed valency electron transfer using cyclic differential pulse voltammetries laboratory practice students use ferrocene dimer consisting two ferrocene centers covalently bonded dimethylethylene bridge platform measurement inner sphere degree electronic communication ferrocene redox centers measured magnitude equilibrium constant comproportionation reaction yields mixed valent ferrocene dimer students measure difference electrochemistry ferrocene dimers categorize ferrocene dimers according robin day classification include interactive presentation student handout one sample quiz
objective germany patients posttraumatic stress disorder ptsd related childhood sexual abuse csa often receive inpatient treatment however data utilization costs mental health care well impact trauma focused treatment missing methods within context randomized controlled trial mental health service utilization assessed female patients ptsd related csa data psychiatric psychotherapeutic inpatient outpatient treatment psychotropic medication obtained year inpatient dbt ptsd results mean total costs utilization psychiatric psychotherapeutic care use psychotropics sic per patient year sic year dbt ptsd significant cost decrease due large reductions inpatient treatment days average days days dbt ptsd outpatient treatment psychotropic medication remained unchanged conclusion ptsd related csa associated high utilization costs mental health care results suggest dbt ptsd might contribute reducing mental health care costs
collagen crosslinking important determinant quality bone material previously shown suppressed bone turnover high doses minodronic acid alendronate increases compressive strength vertebra also increases microdamage accumulation monkey bone aim study examine effects bisphosphonates collagen crosslinks intrinsic material properties addition microdamage accumulation vertebral cancellous bone ovariectomized cynomolgus monkeys sixty female monkeys aged years divided five groups sham ovariectomized groups treated daily months lactose vehicle three groups given minodronic acid daily alendronate daily orally sacrifice lumbar vertebrae subjected histomorphometry microdamage measurement analysis collagen crosslinking compressive mechanical tests minodronic acid caused dose dependent suppression increased bone remodeling due ovariectomy low dose minodronic acid suppressed remodeling level alendronate however low dose minodronic acid change microdamage accumulation collagen maturity pentosidine level whereas high dose minodronic acid alendronate increased parameters compressive ultimate load increased following high dose minodronic acid alendronate treatment altered reduction intrinsic material properties caused ovariectomy findings suggest deterioration bone material formation pentosidine microdamage induced minodronic acid less expected based extent remodeling suppression comparison alendronate reflected significant change mechanical properties elsevier inc rights reserved
new advanced manufacturing technologies alias additive biomanufacturing allow design fabrication range products pre operative models cutting guides medical devices scaffolds process printing dimensions cells extracellular matrix ecm biomaterials bioinks powders etc generate vitro vivo tissue analogue structures termed bioprinting advance additive biomanufacturing many aspects learn wider additive manufacturing industry progressed tremendously since introduction manufacturing sector first review gives overview additive manufacturing industry academia efforts addressing specific challenges technologies drive toward enabled industrial revolution considerations poly lactides biomaterial additive biomanufacturing discussed challenges wider additive biomanufacturing field discussed terms biomaterials computer aided design engineering manufacturing additive biomanufacturing printers hardware system integration finally outlook additive biomanufacturing discussed elsevier rights reserved
autism spectrum disorder asd neurobiological disorder significantly impairs children social interaction verbal nonverbal communication behaviors questions theory mind tom deficits asd generated large number empirical studies article reviews current studies relationship tom asd including contributions understanding social academic manifestations asd several themes emerge enhanced language verbal abilities facilitate better tom understanding implicit tom elements incorporate parallel processing pose difficulties explicit ones general multimodal interventions effective specific interventions brief overview followed review emerging research role domain general cognitive skills executive function central coherence development tom next summary studies addressing tom across development social academic manifestations presented article ends critical review tom intervention studies suggests generalization may likely occur tom targeted part broader sociocognitive interventions rather isolated skill
chip design novel chopper stabilized operational amplifier presented chopper wave modulation demodulation used architecture noise decreased largely extend input common mode voltage range novel rail rail differential amplifier adapted input stage range input common mode voltage zero power supply consumed current input signal frequency khz output signal thd
study investigated role self esteem social need belong loneliness competitiveness shyness health smoking drinking behaviors hungarian adolescents psychosomatic symptoms sample students ages years debrecen hungary completed questionnaires besides descriptive statistics correlation multiple regression analyses applied test interrelationships frequency analysis revealed fatigue commonly experienced psychosomatic symptom sample followed sleeping problems lower back pain girls reported experiencing symptoms multiple regression analyses suggested need belong shyness competitiveness may serve social behavioral risk factors adolescents psychosomatic symptomatology whereas self esteem may play protective role role social health behaviors modified analyzed gender psychosomatic index score positively related smoking shyness among girls need belong among boys self esteem provided protection sexes conclusion conclude problems social relationships namely unmet need belong competitiveness shyness may lead psychosomatic health complaints whereas self esteem may serve protection findings suggest social skills training strengthening self esteem important part children health promotion programs schools improve psychosomatic health well
proportional integral derivative pid control widely used industrial equipment however transient response obtained poor fixed pid controller used nonlinear systems moreover hydraulic excavator consists nonlinear system derivative element case system output track reference signal integral element controller canceled derivative element system order improve transient response tracking performance data driven pid control tuning updating pid gains proposed however data driven pid control method could improve tracking performance paper controller design scheme based data driven approach hydraulic excavator proposed moreover control parameters proposed scheme updated line manner using fictitious reference iterative tuning effectiveness controller verified simulating control behavior hydraulic excavator
air conditioner installation general air compressor installed external building well heat rejected pretty location air compressor must used supporting leg support weight day production supporting leg measure reduce cost reduction material weight strength usable according material weight reduction supporting leg shape cross section may change point work objective work minimizing material weight also supportable weight problem solve optimization technique optimization technique way known widely used structural design problem genetic algorithms research used non dominated sorting genetic algorithms method solve multi objective problem minimize cross sectional area minimize deflection supporting leg constraint conditions supporting leg bending stress exceed strength materials
silicon remarkable candidate lithium ion battery anodes due highest theoretical specific capacity low working potential abundance earth however volume changes approximate lithiation delithiation cycling leading pulverization poor electrical contact current collector resulting fast fading capacity overcome problems develop novel free standing anode encapsulating nanoparticles lightweight flexible conductive graphene network utilizing facile freeze drying strategy nanoparticles tightly anchored ultrathin flexible graphene sheets serve mechanical support electrical network buffer layer free standing aerogel exhibits superior electrochemical performance specific capacity mahg cycles current density times traditional electrode foil fabricated typical slurry method
water shortage water pollution climate changes highly interrelated global issues raised immense concerns possible serious adverse effects quality treatment reuse wastewater research aims investigate potential impact triton soilborne fungus aspergillus niger niger well ability organism remove triton contaminated wastewater found triton toxic toward niger irreversible effects whereas inhibitory toward niger reversible effects concentration ranges vary initial concentrations triton niger well contact time initial concentration niger remove respectively triton day increase respectively day another experiment showed initial concentration niger biodegrade respectively triton day increases day adsorption biodegradation mechanisms employed organism triton removal thus niger enhance biological treatment wastewater
possible construct age curve denoting ages women biologically old reproduce constructed curve based distribution female age last birth natural fertility populations reflecting ages women become biologically old children median age last birth alb females similar years age across range natural fertility populations suggests fairly universal pattern age related fertility decline however little known distribution female alb present era modern birth control impossible assess age specific distribution alb reliable information lacking could benefit couples envisage delaying childbearing study review high quality historical data sets natural fertility populations distributions female age last birth analysed studies selected used retrospective cohort design women followed age reproductive years using common set eligibility criteria large data files natural fertility populations prepared analysis could performed parallel across populations data alb confounding variables presented box whisker plots denoting percentile distribution age last birth population analysis includes estimation kaplan meier curves age last birth population hazard curve alb obtained plotting smoothed hazard curve population taking lowest hazard within time period least years lowest hazard curve transformed cumulative distribution function representing composite curve end biological fertility curve based data three six populations lowest hazards end fertility selected six natural fertility populations comprising eligible women populations represent different historical time periods distribution ages last birth remarkably similar curve denoting end fertility indicates women last birth age years meaning almost able least one child thereafter cumulative curve end fertility slowly increases age years age years age years age years thereafter rises rapidly age almost age years approaching age years may argued historical fertility data apply present time however age dependent decline fertility similar current populations consistent pattern seen women treated donor insemination furthermore reproductive ageing note unlikely conserved biological process high degree heritability would changed significantly within century two argue age specific alb curve used counsel couples envisage children future findings challenge unsubstantiated pessimism regarding possibility natural conception age years
brushless doubly fed machine bdfm brushless electrical generator allows variable speed operation power converter rated fraction machine rating paper details example implementation bdfm medium scale wind turbine details simplified design procedure based electrical magnetic loadings given along results tests manufactured machine show bdfm scale works expected bdfm chosen slower thus larger turbine original induction machine implementation turbine system discussed including vector based control scheme ensures bdfm operates demanded speed maximum power point tracking mppt scheme selects rotor speed extracts power incident wind conditions
goal work develop easy use engaging irrigation scheduling tool cotton operates smartphone platform model drives cotton smartlrrigation app cotton app interactive based soil water balance model cotton app uses meteorological data weather station networks soil parameters crop phenology crop coefficients irrigation applications estimate root zone soil water deficits rzswd terms percent well inches water cotton app sends notifications user rzswd exceeds phenological changes occur rain recorded nearest weather station operates ios android operating systems released march soil water balance model calibrated validated using data replicated plot experiments commercial fields cotton app evaluated field trials three years performed well compared irrigation scheduling tools geographical footprint currently limited states georgia florida united states enabled use meteorological data weather station networks states new version currently development use national gridded meteorological data sets allow cotton app used cotton growing areas united states elsevier rights reserved
application integration process creating impartially designed application systems operate collectively whole integration easy task developers combine disparate structural designs include different data process object models developers must also make solution operate across several operating systems middleware technologies databases integration essential new technology solution study discusses different approaches feasible solutions estimates disparate enterprise solution synchronization also discuss influential forces made enterprise precarious summarize inspection areas selecting method individual enterprise requirements moreover provide important aspects considered planning creating integration solution
echinococcosis preventable neglected zoonosis india although disease domestic animals usually asymptomatic huge economic losses reported due cystic echinococcosis livestock india molecular characterization echinococcus dog populations previously carried punjab india total pet stray dog faecal samples collected examined presence eggs taeniidae family punjab india base pair fragment mitochondrial rrna gene amplified presence sheep strain granulosus reported detected eggs taeniidae family per cent faecal samples high prevalence recorded stray dogs living near slaughter shops post mortem areas prevalence granulosus sheep strain using pcr found per cent naturally infected dogs first study confirming presence granulosus sheep strain dogs punjab india results reveal presence sheep strain granulosus demand implementation animal birth control programme control stray dog population country
computer numerical control technology mechanical movement digital information work process control technology data processing reverse engineering important technical aspects determines whether subsequent model reconstruction process easy accurate manner paper computer numerical control machining complex surfaces feature full potential existing computer numerical control equipment automatic control system designed make computer numerical control machining equipment achieve higher processing speed high precision machining computer numerical control equipment order achieve high efficiency machining
widespread distribution smart mobile devices offers promising perspectives timely collection huge amounts data realizing sophisticated mobile data collection applications numerous technical issues arise example many real world projects require support different mobile operating systems platform specific peculiarities must properly handled existing approaches often rely specifically tailored mobile applications drawback changes data collection procedure result costly code adaptations remedy drawback model driven approach proposed enabling end users domain experts create mobile data collection applications model relies complex questionnaires called instruments instrument contains information data collected additionally comprises information shall processed different mobile operating systems purpose developed advanced mobile kernel service capable processing sophisticated instruments various platforms paper discusses fundamental kernel requirements introduces developed architecture altogether mobile service allows effective use smart mobile devices data collection application scenarios clinical trials
parent reported developmental concerns first step toward screening intervention children risk asd however little known extent parental well child behavior contribute parental concerns especially families already one child asd study included parents month old high risk toddlers examine extent parents well parenting stress self efficacy children behavior expressive language social communication contribute parents concerns regarding toddler development results revealed parental concerns predicted well well toddler expressive language highlighting importance addressing needs parent child intervention settings
paper grid connected doubly fed induction generator controlled sliding mode controller smc used maximize wind energy conversion system wecs output power smc implemented using pid controller tuned using new algorithm based hybrid differential evolution linearized biogeography based optimization lbbo biogeography based optimization bbo evolutionary optimization algorithm based mathematical model organism distribution bbo permits recombination solutions features migration new migration model based sigmoid function proposed analysis lbbo conducted using six different models including sigmoid model performance tested benchmark functions comparison reveals sigmoid model best performance therefore lbbo sigmoid model used optimize controller parameters maximize wecs output power lbbo sigmoid model compared tyreus luyben tuning method genetic algorithm linearized bbo lbbo results showed lbbo best performance proposed algorithm verified using experimental setup maximization generated power wecs reducing power loss elsevier ltd rights reserved
tauopathies encompass broad range neurodegenerative diseases featuring extensive neuronal death cognitive decline however research past years failed significantly advance understanding tau causes dementia limiting design rational therapeutics become evident need expand understanding tau physiology order delineate tau may contribute pathology review discusses recent evidence uncovered novel aspect tau function based previously uncharacterized localization synapse multiple streams evidence support critical role synaptic tau regulation synapse physiology particular long term depression form synaptic weakening dependent presence tau hippocampal neurons regulation tau specific phosphorylation events downstream gsk beta activation appears integral signaling role also describe regulation synapse physiology tau phosphorylation may inform understanding tauopathies comorbid diseases work provide platform future tau biology research addition therapeutic design
background production false memories fms normal phenomenon affected neurodegenerative diseases alzheimer disease studies investigated fms patients dementia lewy bodies dlb objective aim preliminary study assess fms patients dlb identify underlying cognitive deficits influencing production fms dlb methods ten patients nine dlb patients performed memory task free recall recognition coupling two paradigms namely drm deese roediger mcdermott paradigm promoting production fms remember know paradigm allowing investigate phenomenological experience recollection memory standard cognitive evaluation memory executive instrumental functions completed assessment results found dlb group free recall number fms substantially identical groups recognition however fms differed phenomenological experience responses dlb patients responses patients none tests standard neuropsychological evaluation correlate measures interest fms conclusion patients responses associated fms reflect alteration source memory dlb patients critical item lead sense familiarity without recollection circumstances item encoded hence responses indicates preservation source memory contrary expectations type fms groups correlated cognitive profile hence cognitive processes underlying fms appear different lbd fms seem independent memory executive abilities diseases
bangor gambling task bgt bowman turnbull simple test emotion based decision making contingencies varying across five blocks trials first study characterise bgt performance survivors traumatic brain injury tbi relative healthy controls study also aimed explore sub groups cluster analysis identify predictors task performance multiple regression thirty survivors tbi thirty nine controls completed bgt measures processing speed pre morbid working memory executive function results showed survivors tbi made gamble choices controls total bgt score although groups significantly differ using cut score impaired performance unexpectedly groups significantly differ performance across blocks however cluster analysis revealed three subgroups survivors tbi controls represented cluster findings also indicated age group significant predictors overall bgt performance conclusion study findings consistent individual difference account emotion based decision making number issues need addressed prior recommending clinical use bgt
beta adrenergic receptor raising important drug target treatment pathologies diabetes obesity depression cardiac diseases among others several attempts obtain selective high affinity ligands made currently mirabegron available drug market targets receptor approved treatment overactive bladder however fda food drug administration usa mhra medicines healthcare products regulatory agency made reports potentially life threatening side effects associated administration mirabegron casting doubts continuity compound therefore utmost importance gather information rational design synthesis new beta adrenergic ligands herein present first combined qsar two dimensional quantitative structure activity relationship qsar comsia three dimensional quantitative structure activity relationship comparative molecular similarity index analysis study series potent adrenergic agonists indole alkylamine structure found series changes made steric hydrogen bond donor acceptor lipophilicity molar refractivity properties compounds generate new promising molecules finally based analysis summary regiospecific description requirements improving beta adrenergic activity given
nano sized ferromagnetic particles may play important role changing improving mechanical performance smart material composed matrix ferromagnetic particles subjected magnetic field material changes shape dimension process called magnetostriction since magnetostriction multi physics phenomenon inevitable adopt numerical framework solve nonlinearly coupled problem present study construction numerical framework material elastic magnetic properties coupled illustrated
high voltage direct current hvdc grids complex multi inputs multi outputs mimo systems whose dynamics difficult assess paper first describes modelling vsc based multi terminal hvdc systems mtdc using different existing cable models recalls benefits singular value decomposition svd approach frequency analysis systems describes perform svd analysis multi terminal hvdc mtdc system state space representation paper discusses results svd analysis regards selection voltage droop parameter voltage constraint grid emphasises impact choice cable model results svd study illustrates cable model influence mtdc system electro magnetic transient emt simulation
long syndrome lqts rare cardiac channelopathy associated syncope sudden death due torsades pointes ventricular fibrillation syncope sudden death frequently associated physical emotional stress management patients lqts consists life style modification beta blockers left cardiac sympathetic denervation lcsd implantable cardioverter defibrillator icd implantation prohibition competitive exercise avoidance prolonging drugs important issues life style modification although beta blockers primary treatment modality patients lqts drugs completely effective patients lifelong icd implantation young active patients associated significant complications lcsd relatively simple highly effective surgical procedure however lcsd rarely used
digital reconstruction single neurons confocal microscopic images important tool understanding neuron morphology function however accurate automatic neuron reconstruction remains challenging task due varying image quality complexity neuronal arborisation targeting common challenges neuron tracing propose novel automatic neuron reconstruction algorithm named rivulet based multi stencils fast marching iterative back tracking proposed rivulet algorithm capable tracing discontinuous areas without interrupted densely distributed noises evaluating proposed pipeline data provided diadem challenge recent bigneuron project rivulet shown robust challenging microscopic imagestacks discussed algorithm design technical details regarding relationships proposed algorithm state art neuron tracing algorithms
bioarchaeological research among prehistoric pacific coast populations shown external auditory exostoses eae found high frequencies california northern channel islands archaeological research demonstrated intense exploitation red abalone haliotis rufescens particularly similar years ago island chumash free diving red abalone subtidal waters eae prevalent prehistoric populations santa rosa island recorded presence absence number side severity eae growths adult individuals three time periods santa rosa island results show similar total population affected including males similar females incidence among females increases early period middle period late period overall lower rates reported channel island pacific coast sites given relatively low percentage santa rosa islanders affected eae red abalones may harvested primarily shallow waters rather deeper subtidal zone data suggest gender differences food procurement activities existed santa rosa island throughout prehistory congruent argument eae activity induced pathology occurs prolonged exposure cold water wind conditions copyright john wiley sons ltd
widespread deployment ground air space sensor sources internet things iot social networks sensor networks integrated applications real time geospatial data ubiquitous sensors especially public security smart city domains becoming challenging issues traditional geographic information system gis mostly manages time discretized geospatial data means structured query language sql database management system dbms emphasizes query retrieval massive historical geospatial data disk limits capability fly access real time geospatial data online analysis real time paper proposes hybrid database organization management approach sql relational databases rdb sql nosql databases including main memory database mmdb distributed files system dfs hybrid approach makes full use advantages nosql sql dbms real time access input data structured fly analysis results meet requirements increased spatio temporal big data linking analysis mmdb facilitates real time access latest input data sensor web iot supports real time query online geospatial analysis rdb stores change information multi modal features abnormal events extracted real time input data dfs disk manages massive geospatial data extensible storage architecture distributed scheduling nosql database satisfy performance requirements incremental storage multi user concurrent access case study geographic video geovideo surveillance public security presented prove feasibility hybrid organization management approach
little research conducted specifically factors bearing special education teacher decision report sexual victimization aim study determine factors role play amongst special education teachers taiwan individual interviews conducted eight female four male special education teachers thematic analysis used interpret data relevant factors categorized accordance ecological system theory proposed bronfenbrenner microsystem factors include consequences reporting severity victimization characteristics students disabilities mesosystem factors include relationship student family colleagues support school administration exosystem factors include paperwork load rotation social workers oppositional positions school government macrosystem factors include emphasis maintaining harmonious relationships colleagues student family doubts applicability mandatory reporting cases involving students disabilities results study indicate need clearer reporting standards students disabilities support resources school administration comprehensive training mandatory reporting policy
objective children autism sitting task behavior problems class study effect three alternative classroom seating devices regular classroom chairs therapy balls air cushions examined students classroom behavior materials methods students autism participated multiple treatments study mashhad tabasom school mashhad iran students behaviors video recorded three phases sitting common chairs phase air sit cushioned phase ball chairs phase sitting times task behaviors quantified momentary time sampling compared different phases important changes additionally gilliam autism rating scale second edition test used examine stereotyped movements social communication skills students research results significant increases seat behaviors thirteen students task behaviors students eight seated therapy balls air cushions significant effects seat task behaviors results also showed significant decrease stereotyped movement increase communication social skills students teachers also preferred use balls air cushioned chairs students conclusion therapy ball chairs facilitated seat behavior decreased autism related behavior students autism spectrum disorder class
purpose implementing health promotion programmes schools key improving children health well difficulties achieving expected results often reported research literature discrepancies expected achieved outcomes originate differences contexts understanding interactions contexts programmes generate variable outcomes therefore critical purpose paper explore outputs programme implemented different school contexts focus pinpoint outputs understand involvement combinations contextual factors identify recurrences combinations design methodology approach retrospective study covers period data collection includes two sets data eight high schools rhone alpes region france written documents interviews school staff realist evaluation used attempt pinpoint outputs relating contextual factors findings results highlight limited outputs programme differences schools appear originate existing school policy prior participation existence project team identification issue priority staff turnover analysis contextual factors led considering implementation process enabling health capacity building enhanced capacity settings communities promote health originality value previous research suggests top implementation standard programme efficient strategy schools engage development suitable health promotion policies potential way forward base support local development health promotion schools better understanding contexts implementation occurs
one primary mechanisms dopamine signaling regulated dopamine transporter dat attractive pharmacological target treatment diseases based dopaminergic dysfunction work demonstrate first time commonly prescribed breast cancer therapeutic tamoxifen major metabolites hydroxytamoxifen endoxifen inhibit dat function tamoxifen inhibits dopamine uptake human dat hdat cells via uncompetitive mixed mechanism endoxifen active metabolite tamoxifen asymmetrically inhibits dat function hdat cells showing preference inhibition amphetamine stimulated dopamine efflux compared dopamine uptake importantly demonstrate effects tamoxifen metabolites dat occur independently activity selective estrogen receptor modulators work suggests tamoxifen inhibiting dat function previously unidentified mechanism
effects kiwifruit large bowel health investigated healthy rats four week old sprague dawley rats given diets containing homogenized green kiwifruit gold kiwifruit glucose solution control green kiwifruit increased fecal output compared control growth certain bacterial species cecum influenced green gold kiwifruit significant increase cecal lachnospiraceae rats fed green kiwifruit diet observed week week green gold kiwifruit diets assisted improving colonic barrier function upregulating expression mucin muc muc toll like receptor tlr trefoil factor genes gold kiwifruit consumption increased colonic goblet cells per crypt week significant negative correlations coli beta defensin tlr expression observed consuming green gold kiwifruit significantly altered biomarkers large bowel health indicating regularly consuming kiwifruit helps attain optimal digestive health
effort cost required convert satellite earth observation data meaningful geophysical variables prevented systematic analysis available observations overcome problems utilise integrated high performance computing data environment rapidly process restructure analyse australian landsat data archive approach data assigned common grid framework spans full geospatial temporal extent observations data cube approach pixel based incorporates geometric spectral calibration quality assurance earth surface reflectance measurement demonstrate utility approach rapid time series mapping surface water across entire australian continent using years continuous resolution observations preliminary analysis landsat archive shows data cube effectively liberate high resolution data complex sensor specific data structures revolutionise ability measure environmental change
continuous spontaneous alternation behavior sab maze used evaluating working memory rodents design automated maze equipped three infrared optocouplers per arm commanded reduced instruction set computer risc microcontroller described software devised recording true entries exits arms experimental settings programmed via keyboard three buttons display sequence arm entries time spent arm neutral zone saved text file non volatile memory later transfer usb flash memory data files analyzed program developed labview environment results exported excel spread sheet file variables measured latency exit starting arm sequence number arm entries number alternations alternation percentage cumulative times spent arm automated maze accurately detected sab decrease produced rats muscarinic antagonist trihexyphenidyl reversal caffeine concordance alternation percentages calculated two trained observers independently watched videos experiments although values time spent arms measured automated system small discrepancies calculated observers bland altman analysis showed concordance three pairs comparisons one indicating system reliable inexpensive alternative study continuous sab rodents
atomic scale tomography ast defined place microscopy considered arguments made ast defined would ultimate microscopy available pathways achieving ast examined conclude atom probe tomography apt may viable basis ast apt conjunction transmission electron microscopy likely path well possible configurations instrumentation achieving ast described concept metaimages introduced data multiple techniques melded create synergies multidimensional data structure coupled integrated computational materials engineering structure properties microscopy envisioned implications ast science technology explored
parental expectations criticism associated self oriented perfectionism strivings sop striving self oriented perfectionism critical sop aitical respectively retrospectively examining parenting childhood never examined within actual child sample similarly differential relations sop striving sop critical affect academic achievement rarely tested within child sample association parenting behaviors outcomes explored present study consisted children aged results replicated previous findings within child sample indicating parental expectations associated sop striving associated academic achievement parental criticism associated sop critical associated negative affect moreover results reveal parenting behaviors related children affect academic achievements directly indirectly perfectionism present investigation lends credence social expectations model flett hewitt oliver macdonald providing evidence within target population highlights divergent patterns sop striving sop critical elsevier ltd rights reserved
acidithiobacillus caldus extremely acidophilic sulfur oxidizer specialized characteristics tolerance low heavy metal resistance gain novel insights genetic complexity chosen six caldus strains comparative survey strains analyzed study differ geographic origins well ecological preferences based phylogenomic analysis clustered six caldus strains isolated various ecological niches two groups group strains smaller genomes group strains larger genomes found obvious intraspecific divergence respect predicted genes related central metabolism stress management strategies two groups although numerous highly homogeneous genes observed high genetic diversity also detected preliminary inspection provided first glimpse potential correlation intraspecific diversity genome level environmental variation especially geochemical conditions evolutionary genetic analyses showed evidence difference environmental conditions might crucial factor drive divergent evolution caldus species identified diverse pool mobile genetic elements including insertion sequences genomic islands suggests high frequency genetic exchange harsh habitats comprehensive analysis revealed gene gains losses dominant evolutionary forces directed genomic diversification caldus species instance horizontal gene transfer gene duplication events group strains might contribute increase microbial dna content novel functions moreover genomes undergo extensive changes group strains removal potential non functional dna results formation compact streamlined genomes taken together findings presented herein show highly frequent gene turnover caldus species inhabit extremely acidic environments shed new light contribution gene turnover evolutionary adaptation acidophiles
ayahuasca hallucinogen brew traditionally used ritual therapeutic purposes northwestern amazon rich tryptamine hallucinogens dimethyltryptamine dmt acts serotonin hta agonist mechanism action similar compounds lysergic acid diethylamide lsd psilocybin controlled use lsd psilocybin experimental settings associated low incidence psychotic episodes population studies corroborate findings controlled use dmt experimental settings use ayahuasca experimental ritual settings usually associated psychotic episodes little known regarding ayahuasca dmt use outside controlled contexts thus performed systematic review published case reports describing psychotic episodes associated ayahuasca dmt intake found three case series two case reports describing psychotic episodes associated ayahuasca intake three case reports describing psychotic episodes associated dmt several reports describe subjects personal possibly family history psychosis including schizophrenia schizophreniform disorders psychotic mania psychotic depression nonpsychotic mania concomitant use drugs however cases also described psychotic episodes subjects without previous characteristics overall incidence episodes appears rare ritual recreational noncontrolled settings performance psychiatric screening administration drugs hallucinogens controlled settings seems significantly reduce possibility adverse reactions psychotic symptomatology individuals personal family history psychotic illness nonpsychotic mania avoid hallucinogen intake
patients inflammatory arthritis rheumatoid arthritis psoriatic arthritis ankylosing spondylitis higher rates cardiovascular mortality increased cardiovascular risk explained extent lot research currently conducted improve understanding pathogenesis risk stratification optimal cardiovascular risk management review sought report epidemiological data pertaining cardiovascular disease burden patients inflammatory arthritis underlying mechanisms accounting excessive cardiovascular risk along recommendations regarding risk assessment management patient population
article three aims first examines notion evidence informed practice benefits well recent educational policy designed promote schools use evidence second examines four distinct overlapping interdependent factors school leaders need consider wish establish evidence informed practice within school factors existence teacher capacity engage research data school cultures attuned evidence use schools promoting use research part effective learning environment existence effective structures system resource facilitate research use sharing best practice third describe article authors undertook survey practitioners relation factors also resultant data built gradient boosted tree predictive model examine potential policy levers available school leaders wishing promote evidence use schools conclude article setting factors likely increase support evidence informed change within schools well boost instances evidence informed practice teachers
cooperation plays important role distributed reasoning systems ambient environment systems ambient entities diverse perception capabilities cooperate reasoning process sharing parts local knowledge achieve set common goals nevertheless previous work distributed reasoning assumed ambient entities keep local knowledge private reason top manner reach goals approaches fit features ambient environment paper presents tailored distributed peer peer approach modeling reasoning context information using cooperation ambient environment ambient entities cooperate sharing parts local context information reason bottom manner propose operational model present prototype implementation proposed approach
ankylosing spondylitis chronic inflammatory disorder mainly affects sacroiliac joints axial skeleton aim study assess serum prolidase level spl association disease activity patients prospective study included patients thirty age gender matched healthy controls enrolled patients considered active basdai score aeyen inactive basdai score patients active group patients inactive group anti tnf monoclonal antibody treatment started patients active group active patients reassessed months later basdai asdas visual analogue scale short form general health survey questionnaire reactive protein erythrocyte sedimentation rate spl measured patients treatment spl significantly lower inactive patients control group also spl significantly lower active patients inactive patients activity parameters successful separating active inactive patients however parameter could distinguish active patients inactive patients prolidase optimum cutoff point spl identify patients active sensitivity specificity positive predictive value negative predictive value serum prolidase level successful measuring disease activity high sensitivity specificity basdai superior activity parameters
sequences similarity analysis one major topics bioinformatics helps researchers reveal evolution relationships different species paper outline new method analyze similarity proteins discrete fourier transform dft dynamic time warping dtw original symbol sequences converted numerical sequences according physico chemical properties obtain power spectra sequences dft extend spectra length calculate distance different sequences dtw method tested different datasets results compared software algorithms comparison find scheme could amend wrong classifications appear software comparison shows approach reasonable effective elsevier inc rights reserved
background spite verifiable achievements obtained gender equity one wonders still exist societies gendered activities roles household level study states affirmative prediction gender role organized four different nuclei instrumentality inside outside home men expressiveness instrumentality inside home women pertaining two clearly different domains household activities men household activities women method women men completed gender roles questionnaire grq results obtained results showed men women certain household activities roles frequency four dimensional approach fits data better one dimensional even better two dimensional approach household gender roles men women separately conclusion discussion focuses implications results research education
technological advancements contemporary learning theories redesigned school environment embed ict technology many aspects learning process particular ict technology exploited monitor learners behaviour learning activities example identify whether learner paying attention lecture poster presents functional requirements visual tool smart classroom allows teachers view customize attention monitoring subsystem individual student classroom whole order improve educational process preliminary usability findings regarding design reported collected cognitive walkthrough evaluation hci experts
paper includes examples innovative learning study materials created university west bohemia uwb pilsen faculty mechanical engineering fme learning project described paper creates study materials vision future development new methods forms education applied learning project agreement modern trends information communication technologies ict consists design projects created cooperation industrial companies pdf files part learning project one way making outputs specialized computer aided design cad software available wide field potential applicants could inspired study due materials
bachelor degree program mechanical engineering strength materials statics among fundamental applied courses use experiments simulations order improve quality learning subjects overstated strength materials analysis pure bending transverse loading two important objectives similarities differences behavior structure types loadings understood thoroughly behaviors similar terms generating bending stresses different comes producing shear stresses teaching strength materials many years second author experienced many students problem differentiating phenomena problem students obviously see different values internal forces stresses cases concepts usually taught lectures using diagrams formulas textbooks method improved giving students opportunity gain hands experience use cad software simulations experience also provides means comparing theoretical simulation experimental results research address mentioned need two devices designed fabricated tested main question answered using devices transverse loading beam compares pure bending beam answer question research two devices designed constructed device consists beam two polymethyl methacrylate pmma simply plexiglas layers loads applied beams order produce either transverse loading pure bending moment analyzing pure bending four point bending set fabricated shear force generation transverse loading tip load applied cantilever beam pasta used test specimen identify two cases shear force generates experiments augmented computer simulation theoretical results used classrooms university southern maine usm objective facilitate understanding concept usually difficult students comprehend using traditional teaching methods also using statics course separate test setup analyzing equilibrium hinged bar subjected tip force designed built tip force applied measured using spring scale three parameters varied device bar mass angle well angle applied loading students use device statics course explore concept moment force well compare theoretical experimental predictions load needed maintaining equilibrium bar
people spend third lifetime sleep exercise light exposing critical influence sleep quality exercise affects sleep efficiency light exposing affect sleep circadian rhythm paper investigates impact sleep rhythm efficiency html based behavior recording analytic service healthy sleep space hss hss takes advantages important features html consistent user experience across multiple mobile device offline processing etc hss users record sleep behavioral information analyze collected information cloud regardless internet condition type mobile devices propose simple sleep quotient index evaluate quality sleep based values hss provides appropriate exercise light exposing prescriptions users eventually modify daytime behavior improve sleep quality
background quantum chemistry many tasks reoccurring frequently geometry optimizations bench marking series etc workflows help reduce time manual job definition output extraction workflows executed computing infrastructures may require large computing data resources scientific workflows hide infrastructures resources needed run requires significant efforts specific expertise design implement test workflows significance many workflows complex monolithic entities used particular scientific experiments hence modification straightforward makes almost impossible share address issues propose developing atomic workflows embedding meta workflows atomic workflows deliver well defined research domain specific function publishing workflows repositories enables workflow sharing inside among scientific communities formally specify atomic meta workflows order define data structures used repositories uploading sharing additionally present formal description focused orchestration atomic workflows meta workflows conclusions investigated operations represent basic functionalities quantum chemistry developed relevant atomic workflows combined meta workflows workflows defined structure quantum chemistry workflow library uploaded workflows shiwa workflow repository
teenage pregnancy refers early adolescence puberty pregnancy maternity period involves different consequences personal family social level stressing question mortality morbidity abortion sexually transmitted diseases school dropout positions vulnerability poverty reproduction etc hand factors favor existence problem geographical social family individual issues public policies existing resources educational level knowledge styles unhealthy lifestyle early marriage traditional gender roles assigned women etc using shown mothers early age parents teenage mothers metropolitan area monterrey qualitative research arises content analysis categorization interviews aim identifying perceptions regarding pregnancy early age well causes consequences measures place results show manifestation different individual causes political social family sample well various individual consequences family also shows school main source information intends review relevant preventive intervention measures taking account mothers teenagers minimize potential consequences described
many survivors rape seek post assault care recent change status emergency contraception plan counter otc product may changing post assault care seeking descriptive study quantify otc use post assault period elicit survivors desires care data collected women purchasing otc university pharmacies students undergraduate university class quantitative results indicate annual prevalence rates post assault otc use qualitative analyses indicate otc important incomplete form post assault care future work focus intervention development provide otc users information post assault resources prevent long term sequelae
since situ preservation archaeological material become widespread european union need stop active attack teredo navalis wood boring mollusc waterlogged archaeological wood become urgent aim current study examine ability two plastic materials terram plastic membrane stop initial attack navalis effects wood active woodborer degradation blocks pinewood submerged southern part kattegat denmark shipworm known prolific settling attack confirmed blocks removed wrapped either terram polypropylene polyethylene proprietary plastic membrane polyethylene normally used fishing piles piers protection shipworm denmark optical oxygen sensor packed together block measure amount available oxygen around wood one week oxygen level around test blocks wrapped plastic membrane dropped drastically lead death shipworms within test blocks one four weeks although new shipworm attacked wood wrapped terram geotextile impede passage oxygenated seawater living individuals found blocks weeks wrapping submersion elsevier ltd rights reserved
senior author introduced modern concept migraine surgery since articles published eight centers across europe asia describing positive outcomes surgery cases surgeons neurologists patients increasingly interested new treatment method however majority publications topic found surgical literature articles presented neurology journals review introduction migraine surgery neurologists surgeons view discusses surgical treatment migraine headaches based discoveries made articles published senior author outlines current history migraine surgery presents evidence supporting effectiveness tries dispel claims seeing placebo effect describes detection trigger sites outlines surgical techniques peripheral nerve decompression hope review generate positive discussion surgeons neurologists lead interdisciplinary collaboration benefit patients future
fibrotic diseases well understood represent number different diseases characterized development severe organ fibrosis without obvious cause devastating diseases idiopathic pulmonary fibrosis ipf scleroderma diseases poor prognosis comparable endstage cancer uncurable given phenotypic differences assumed different fibrotic diseases also different pathomechanisms demonstrate many endstage fibrotic diseases including ipf scleroderma myelofibrosis kidney pancreas heart fibrosis nonalcoholic steatohepatosis converge activation transcription factor jun pathologic fibroblasts expression related transcription factor fra restricted pulmonary artery hypertension induction jun mice sufficient induce severe fibrosis multiple organs steatohepatosis dependent sustained jun expression single cell mass cytometry revealed jun activates multiple signaling pathways mice including pakt also induced human disease alpha antibody treatment vegf pik inhibition reversed various organ jun mediated fibroses vivo data suggest jun central molecular mediator fibrotic conditions
study describes first time distribution calcium binding protein calretinin anterior thalamic nuclei atn guinea pig development brains animals ranging embryonic day postnatal day used study immunoreactive perikarya present among atn thick bundles fibers containing crossing anteromedial nucleus first neurons appeared lateral part bundles fibers disappeared whole area displayed closely packed perikarya stage also appeared neurons anteroventral nucleus particularly lateral part along dorsal border moreover short thin bundles fibers observed medial part atn newborns already showed adult like distribution pattern perikarya distributed homogenously number slightly decreased comparison anterodorsal nucleus devoid neurons studied stages conclusion results demonstrate calretinin appears first time neurons various anterior thalamic nuclei guinea pig day prenatal development elsevier rights reserved
many patients visit centre hereditary metabolic diseases remarkably also suffer child psychiatric disorder child psychiatric disorders may first sign manifestation underlying metabolic disorder lack knowledge metabolic disorders child psychiatry may lead diagnoses missed patients therefore also risk accessing efficacious treatment proper counselling search literature occurrence child psychiatric disorders adhd autism psychosis learning disorders eating disorders metabolic disorders search literature conducted performing broad search pubmed using terms adhd metabolic disorders autism metabolic disorders psychosis metabolic disorders learning disorders metabolic disorders eating disorders metabolic disorders based inclusion criteria concerning clear psychiatric disorder concerning metabolic disorder titles abstracts screened resulted relevant articles thorough literature search provides child adolescent psychiatrists overview metabolic disorders associated child psychiatric symptoms main characteristics recommendations investigations
study engineering experimentation plays great role understanding concepts teaching engineering always challenging theoretical study augmented experiments students get feel real life applications concepts study automation control laboratory area students verify ladder diagrams develop various applications unless programmable logic controller plc lab new concept virtual lab enabled teach concepts ladder diagrams development control systems using plc easily students could develop ladder diagrams design digital control systems using simulation environment given virtual lab platform implement logics developed study carried institute exit surveys shows students convinced results could test platform
paper new transadmittance mode first order pass filter suitable low voltage operation presented proposed circuit employs simple cmos transconductor two inverting voltage buffers single capacitor three resistors fully cascadable due high impendance voltage input high output impedance current output theoretical results verified spice simulations using ptm level cmos process bsimv parameters supply voltages used
present study aimed investigate effects mood stabilizers specifically lithium valproate vpa pik akt signaling pathway brains rats subjected ouabain oua induced animal model mania addition effects gsm beta inhibitor manic like behavior induced oua evaluated first experimental protocol wistar rats received single icv injection oua artificial cerebrospinal fluid acsf day following icv injection rats treated days intraperitoneal injections saline vpa twice day second experimental protocol rats received oua acsf oua plus acsf plus day oua injection locomotor activity measured using open field test addition analyzed levels pik mapk akt gsk beta brain rats immunoblot vpa reversed oua related hyperactivity oua decreased pik akt gsk beta levels vpa improved oua induced cellular dysfunctions however effects mood stabilizers dependent protein brain region analyzed addition reversed manic like behavior induced oua findings suggest manic like effects ouabain associated activation gsk beta vpa exert protective effects oua induced inhibition gsm beta pathway elsevier ltd rights reserved
several mutations within shank gene identified autism spectrum disorder patients several studies started show mutations could impact different brain circuits leading heterogeneity disease show compared mouse model lacking shank proline rich containing isoforms mouse model lacking shank ank yrin domain containing isoforms excitatory synaptic transmission within ventral tegmental area affected discuss possibility different domains shank involved regulating synapses circuit specific manner resulting different behavioral synaptic phenotypes
objective determine bone bruise characteristics seen magnetic resonance imaging associated patient reported outcomes prior following anterior cruciate ligament reconstruction combined presence bone bruises articular cartilage pathology results inferior year outcomes design bone bruise volume severity measured patients preoperative magnetic resonance imaging medial lateral femoral condyle mfc lfc medial lateral tibial plateau mtp ltp using costa paz classification modified version roemer bohndorf technique relationships bone bruise volume severity knee injury osteoarthritis outcome score koos international knee documentation committee ikdc scores assessed pre postoperative koos ikdc scores compared bone bruises either without combined local articular cartilage pathology results patients bone bruise least region bone bruises regions ltp bruises common followed lfc mtp mfc neither bone bruise volume severity associated inferior postoperative outcomes subset patients bone bruises combined articular cartilage pathology times likely symptomatic year follow without articular cartilage pathology conclusions volume severity preoperative bone bruises alone associated year outcomes however bone bruises combined local articular cartilage pathology appear symptomatic acl reconstruction
cultivating empathy presumed benefit mindfulness possibility rarely investigated experimentally examined whether five minute mindfulness exercise would cultivate empathy relative two equally brief control exercises relaxation mind wandering examined whether mindfulness would especially beneficial people autistic narcissistic traits results showed effect mindfulness relative control conditions mind reading empathic responding prosocial behavior mindfulness effects independent autistic traits unexpectedly people higher autistic traits show increased prosocial behavior across conditions intriguingly mindfulness improved mind reading non narcissistic people reduced narcissistic people findings question whether brief mindfulness exercise sufficient building empathy
effect dilute alloying additions cathodic reaction thermodynamics occurring magnesium basal surface studied using first principles approach stability alloying additions surface considered function surface energy shown function implicit solvation work function alloyed surfaces also largely affected use implicit solvent alloyed surfaces becoming increasingly noble pure magnesium surface becoming less noble solvation cathodic reaction considered three part sequence water dissociation hydrogen diffusion hydrogen evolution water dissociation reaction became endothermic dilute alloying whereas enhanced already favorable water dissociation reaction two mechanisms preventing hydrogen evolution considered early period elements preventing hydrogen evolution surface binding adsorbed hydrogen whereas late period elements prevented local hydrogen recombination repelling adsorbed hydrogen
purpose purpose paper investigate analyze actual developments within ppp projects influences business cultures management processes international ppp projects paper focusses especially procurement potential project partners selected design methodology approach researcher adopted recent model literature analyzing business cultures within construction processes especially called model used earlier developed published within construction management literature based analysis literature comparable situations conclusions recommendations made managing international ppp projects especially project partners selection phase findings actual approaches within international ppp projects need structured approach selection project partners suggested use past performance information based financials organizational data experiences also behavioral businessculture data experiences information needs structured proper way suggestions given focussing discussion future outlook research limitations implications would useful test findings actual cases testing implications outcome practical implications better understanding business cultures influences increases awareness project participants advantage suggested extra selection criteria might reduce risk conflicts project execution total project life cycle social implications improving actual practices selection suitable parties actual future ppp projects great value effective possible within selection process especially approach prevent several unpleasant situations afterwards operation time life cycle ppp project way proper handling business culture influence save clients stakeholders involved society large amount possible conflicts claims etc afterwards originality value proposed approach contributes better understanding project processes stakeholders especially foreseen project participants current selection processes still adopt structured approach incorporating past performance behavioral data experiences structuring using properly result successful ppp projects within fast growing international ppp market
minimum spanning tree mst construction classical problem distributed computing creating globally minimized structure distributedly self stabilization versatile technique forward recovery permits handle kind transient faults unifiedmanner loop free property provides interesting safety assurance dynamic networks edge cost changes operation protocol present new self stabilizing mst protocol improves previous known approaches several ways first makes fewer system hypotheses size network upper bound size need known participants secondly loop free sense guarantees spanning tree structure always preserved edge costs change dynamically protocol adjusts new mst finally time complexity matches best known results space complexity results show protocol efficient date
varc valve academic research consortium transcatheter aortic valve replacement set standard selecting appropriate clinical endpoints reflecting safety effectiveness transcatheter devices defining single composite clinical endpoints clinical trials standardization exists circumferentially sutured surgical valve paravalvular leak pvl closure document seeks provide core principles appropriate clinical endpoints endpoint definitions used clinical trials pvl closure devices pvl academic research consortium met review evidence make recommendations assessment disease severity data collection updated endpoint definitions class grading scheme evaluate pvl developed concordance varc recommendations unresolved issues field outlined current pvl academic research consortium provides recommendations assessment disease severity data collection endpoint definitions future research field warranted american college cardiology foundation european society cardiology
printed carbon graphite materials primary common component majority screen printed sensors screen printing allows scalable manufacturing solution accelerating means novel sensing materials make transition laboratory material commercial product common bottleneck thick film printing process controlled drying carbon paste material study undertaken examines interaction material solvent printed film conductivity process consistency study illustrates possible reduce solvent boiling point significantly increase process productivity maintaining process consistency lower boiling point solvent also beneficial effect conductivity film reducing sheet resistance proposed result greater film stressing increasing charge percolation greater inter particle contact simulations material performance drying illustrate multi layered printing provides time efficient manufacturing method findings implications volume manufacturing carbon sensor electrodes also implications applications conductive carbon used electrical circuits photovoltaic devices
objectiveto investigate differences topographical pressure pain sensitivity maps scalp patients migraine healthy controls considering chronicity episodic chronic side strictly unilateral bilateral symptoms backgroundit seems trigeminal area sensitized migraine study investigated topographical pressure sensitivity maps scalp patients migraine methodspressure pain thresholds ppts assessed points distributed scalp patients episodic migraine chronic migraine healthy age matched healthy controls blinded design topographical pressure pain sensitivity maps based interpolation ppts constructed clinical features migraine anxiety depression hospital anxiety depression scale hads collected resultsthe multivariate ancova revealed significant differences ppt points anterior posterior gradient found lowest ppts located frontal regions highest ppts occipital areas groups conclusionswe found patients migraine exhibited generalized pressure pain hypersensitivity head compared healthy controls hypersensitivity similar episodic chronic unilateral bilateral migraine topographical pressure pain sensitivity maps revealed anterior posterior gradient pressure pain sensitivity migraine control groups
free viewpoint video recent trend represent scene objects solids rather using multiple depth maps point clouds used computer graphics long time recent possibility real time capturing rendering point clouds favored meshes order save computation point cloud associated position color devise method compress colors point clouds based hierarchical transform arithmetic coding transform hierarchical sub band transform resembles adaptive variation haar wavelet arithmetic encoding coefficients assumes laplace distributions one per sub band laplace parameter distribution transmitted decoder using custom method geometry point cloud encoded using well established octtree scanning results show proposed solution performs comparably current state art many occasions outperforming much computationally efficient believe paper represents state art intra frame compression point clouds real time video
along barley andrice maize provides staple food half world population maize ears regularly infected fungal pathogens fusariumgenus besides reducing yield also taint grains toxic metabolites earlier work shown maize ears infection single fusarium strains detectable volatile sensing innature infectionmostcommonlyoccurswithmorethanasinglefungalstrain hence tested interactions two strains would modulate volatile emission infected ears purpose ears hybrid dwarf maize variety simultaneously infected different strains fusarium graminearum verticillioides resulting volatile profiles compared ones ears infected single strains disease severity fungal biomass concentration oxylipin hydroxy octadecadienoic acid signaling molecule involved plant defense monitored correlated volatile profiles results demonstrate simultaneous infections hybrid dwarf maize competitive fungal strains largest influence volatile profile infected ears concurrent single inoculations volatile profiles reflected disease severity additionally data indicate dwarf maize hybrid maize might emit common sesquiterpenoids specific markers upon fungal infection overall suggests volatile profiles might good proxy disease severity regardless fungal competition taking place maize ears appropriate sensitivity reliability volatile sensing thus appears promising tool detecting fungal infection maize ears field conditions
objective paper explore bim building information modeling applications sustainable infrastructures response global warming shortage energy resources challenges environmental degradation humans trying build low carbon eco cities popularize low carbon green buildings building green refers entire life cycle building includes maximizing conservation resources energy water land materials protecting environment reducing pollution providing people healthy comfortable efficient use space establishing harmony nature architecture field green sustainable buildings bim integrated analog energy buildings air flow analysis buildings sunshine ecosystems using bim possible reduce waste improve construction quality bim builds visualization digital building models multi dimensional digital design solutions provide simulation analysis scientific collaboration platforms designers architects utilities engineers developers even end users moreover bim helps take advantage three dimensional digital models design construction projects operational management authors published elsevier
great interest use biomarkers assist timely identification alzheimer disease individuals mild symptoms however inclusion biomarkers clinical criteria poses socioethical challenges geneva task force roadmap alzheimer biomarkers established deliver systematic strategic research agenda aka roadmap promote efficient effective validation biomarkers foster uptake clinical practice article summarize workshop discussion geneva task force ethical societal issues working group comprised bioethicists clinicians health economists representatives affected working group identified following key issues need included roadmap improving access services timely diagnosis need diagnostic research protocol moving clinical routine recruitment diagnostic research protocols absence effective therapy respect autonomy individual mild cognitive impairment information consent process right know biomarkers results need counseling programs disclosure diagnosis structured environment involvement family members health policies including individuals views protection interests economic costs society elsevier inc rights reserved
understanding need steady state transient performance improvement interior permanent magnet synchronous machine ipmsm drive paper exclusively investigates ipmsm incorporating damper bars rotor electric motor electrified vehicles evs first motivation employment damper bars ipmsm provided justified case study thereafter mathematical model ipmsm drive damper bars rotor developed based axis theory validated experiments performed laboratory ipmsm containing damper bars validated mathematical model employed arrive satisfactory rotor bar parameters existing ipmsm board commercially available moreover replica existing onboard motor without incorporating dampers designed finite element analysis performed investigate various performance characteristics comparative performance analyzes machines without damper bars steady state transient conditions performed wherever necessary results elicited discussed
today power system network become complex responsibilities challenges provide secure reliable quality energy supply communities small entity electrical network known microgrid popular nowadays enhance reliablity secure level energy supply case energy crisis utility network also provide clean energy supply integrating renewable energy sources effectively small scale solar photovoltaic power system suitable provide reliable clean energy supply remote urban communities residential level paper presents basic analysis study stand alone solar photovoltaic power system developed aid matlab simulink software basis residential load profile solar exposure level particular area geelong victoria state simulation result depicts control behavior power system optimum sizing battery storage facility fulfills daily energy needs residential load level study provides good platform develop effective reliable stand alone power system remote communities near future
city governments energy utilities increasingly focusing development energy efficiency strategies buildings key component emission reduction plans energy supply strategies support diverse needs new generation urban building energy models ubem currently developed validated estimate citywide hourly energy demands building level however order cities rely ubems effective model generation maintenance workflows needed based existing urban data structures within context authors collaborated boston redevelopment authority develop citywide ubem based official gis datasets custom building archetype library energy models buildings generated assigned one use age archetypes within cad modelling environment rhinocerosd buildings simulated using doe energyplus simulation program results buildings archetype crosschecked data national energy consumption surveys district level intervention combining photovoltaics demand side management presented demonstrate ability ubem provide actionable information lack widely available archetype templates metered energy data identified key barriers within existing workflows may impede cities effectively applying ubem guide energy policy elsevier ltd rights reserved
scarcity drinking water coastal area bangladesh compels inhabitants highly dependent alternative water supply options like rainwater harvesting system rwhs pond sand filter psf rain feed ponds susceptibility alternative water supply options microbial contamination demands low cost water treatment technology study evaluates effectiveness solar disinfection sodis treat drinking water available sources southwest coastal area bangladesh total households dacope upazila khulna district selected investigate performance sodis data collected two rounds examine fecal coliform escherichia coli coli contamination drinking water household water storage containers sodis bottles thereby determined effectiveness sodis reducing fecal contamination water samples analyzed electrical conductivity turbidity salinity sodis significantly reduced coli contamination household conditions median health risk reduction sodis pond rwhs respectively besides turbidity treated water found less ntu except pond water participating households routinely adopted sodis study
commercial refrigeration systems applying refrigerant still large potential development regarding energy efficiency heat recovery cost efficiency special focus emphasis given system architecture respect increase system efficiency units operated elevated ambient temperatures objective thorough theoretical study investigate energy required different refrigeration systems cooling load conditions system configurations assumed operate high ambient temperatures degrees mean transcritical operations considered following system configurations alternatives sustainable viable competitors conventional hfc supermarket refrigeration systems applied warm climates standard booster cycle baseline expander cycle expander electrical generator booster cycle mechanical subcooler unit working fluid hydrocarbon economiser cycle flash tank parallel compression economiser cycle without flash tank parallel compression ejector supported parallel compression system different cycles evaluated advanced spreadsheets assuming realistic component performances
cognitive behavioral approaches able demonstrate underlying perpetuating factors depression cognitive reactivity association severity depression yet reported aimed compare group outpatients based self reported severity depression srsd identify role specific vulnerability markers depression study population consisted outpatients diagnosed major depressive disorder used mini international neuropsychiatric interview completed demographic clinical data form participants completed leiden index depression sensitivity revised leids hospital anxiety depression scale identify well measured scores leids could discriminate groups based srsd one way analysis variance used examine unique associations srsd hierarchical linear regression analysis performed identify group membership severe depression scores leids entered logistic regression model large small group differences emerged rumination control scores respectively group differences medium range control risk aversion rumination scores subscales explained significant proportion variance srsd overall logistic regression model classified severely depressed patients correctly results indicated rumination risk aversion perfectionism particularly associated severe depression
objective effort address lack evidence based interventions adhd developing south asian countries examined preliminary efficacy behavioral parent training program pakistan method quasi experimental design utilized eighty five year old children clinically significant adhd symptoms participated recruited hospital clinics active treatment group recruited schools waitlist control group parent teacher ratings adhd oppositional defiant disorder odd conduct disorder symptoms impairment collected results using intent treat analyses treatment group showed significant pre post improvement parent reported odd symptoms adhd related impairment teacher ratings showed improvement conclusion study provides preliminary evidence feasibility effectiveness behavioral parenting training children adhd pakistan represents critical first step identifying evidence based treatments pakistani children adhd
recent years considerable effort devoted enhancement distributed hash table dht systems broadcasting capabilities systems typically provide individual node routing broadcast primitive required functionalities information dissemination data aggregation broadcasting also used basis partial keyword searches little work however specifically addressed kademlia well known dht used real applications work exposes particularities system notably xor based distance metrics analytically studies broadcasting techniques applied model estimates node coverage function probability individual messages reach destination also developed validation several broadcasting algorithms implemented comprehensively evaluated considering node coverage messages nodes ratio latency imbalance factor moreover several techniques proposed enhance bare protocols adverse circumstances churn failure rate conditions present include redundancy resubmissions flooding also combinations implemented fully tested analysis strengths weaknesses algorithms additional techniques discussion choices compromises make depending system characteristics application priorities finally presented
paper aims carry analysis way turbulence testing explosive mixture turbulence induced high speed rotation movement shaft motor well rotation interior cooling fan influences maximum explosion pressures recorded carrying type tests electrical rotating machines running paper also presents important results obtained specific laboratory insemex research project carried recently even electric motors environments explosion hazards designed manufactured following principles ones used electric machinery certain particularities related field use required type protection resolved series restrictions imposed electric motor projects widely known case flameproof electric motors well case technical equipment general design manufacture exceeded long time ago stage manufacturers used apply design methods
african american families experiences mild cognitive impairment mci received little attention research literature guided life course perspective analyzed qualitative interview data members african american families including person mci pwmci relative friend highly involved pwmci daily life available relative friend least monthly contact pwmci findings uncovered variability families mci awareness assessment need role changes importance reaching trusted others honoring pwmci care preferences provide care families held varying beliefs engaging outside support families insisted keeping care within family others open use external services showcase diagnosis acceptance family decision making heart african american families respond mci
report detection distribution synaptophysin spy non neuronal enolase nne glial fibrillary acidic protein gfap vimentin vim neuropeptide npy vasoactive intestinal peptide vip expression goat forestomach prenatal development total embryos fetuses examined evaluate protein expression first stage prenatal life birth cases spy immunoreactivity detected days gestation lamina propria submucosa tunica muscularis serosa myenteric plexuses immunoreactivity nne observed days gestation locations well epithelial layer glial cells found days indicated signals corresponding gfap vim days positive staining npy vip observed days rumen reticulum omasum respectively lamina propria submucosa tunica muscularis myenteric plexuses gastric compartments findings indicate possible preparation fetal goat forestomach postnatal function compared ruminant species neuroendocrine cells glial cells peptidergic innervations markers detected earlier compared sheep around stage deer
objective aim study present data concerning children participation german preventive medical examinations children accordance sections german social code book retrospectively recorded public health service offentlicher gesundheitsdienst german province saxony anhalt school entry medical examinations also wanted analyse additional variables recorded per child areas social factors diagnostic findings levels therapeutic care connection degree participation preventive medical examinations methodology statistical analysis anonymised data sets health monitoring system german province saxony anhalt collected health authorities saxony anhalt school entry medical examinations analysis data variables per child performed regard influence degree participation medical examinations using differences frequency examination groups checking significance differences means chi squared test results children saxony anhalt underwent preventive medical examinations children get older participation rates decrease time school entry medical examinations carried average age months children undergone preventive medical examinations children undergone one single examination child gender influence parents decision whether undergo examinations results also reveal children attend day care facilities significantly likely undergone examinations children cared home conclusion retrospective comprehensive collection data concerning children degree participation preventive medical examinations using school entry medical examination suitable identifying connections participation rates social factors diagnostic findings levels therapeutic care children question
adsorption processes responsible detection cancer biomarkers biosensors immunosensors captured various principles detection study used biosensor made nanostructured films polypyrrole antibodies image analysis scanning electron microscopy data made possible correlate morphological changes biosensor concentration cells containing cancer biomarker selectivity biosensor proven distinguishing images obtained exposure biosensor cells containing biomarker acquired cells contain detection confirmed cyclic voltammetry measurements adsorption biomarker probed polarization modulated infrared reflection absorption irras quartz crystal microbalance qcm adsorption described using langmuir freundlich model saturation taking place concentration ucells taken together results point novel ways detect biomarkers type analyte detection based adsorption case majority biosensors
accessible summary england wales people learning disabilities may detained mental health act patients hospital period assessment treatment suffering mental disorder interests health safety protect others patients detained section mental health act apply mental health tribunal decide whether detained psychiatric hospital discharged mental health tribunal power discharge patients hearing patients lack capacity apply tribunal unable tribunal hearing european court ruled unfair patients needs system place ensure patients get tribunal hearing abstract background mental health tribunal long established safeguard patients detained mental health act gives patients effective appeal mechanism ensure legal protection liberty act contains sections allow civil detention case mental disorder right apply tribunal detention underpinned right liberty article european convention human rights echr patients learning disabilities may lack capacity ability challenge detention method article presents case study woman syndrome severe learning disabilities whilst woman detained mental health act could applied review detention mental health tribunal within days lacked capacity instruct solicitors subsequently result appeal case proceeded english european judicial review results european court human rights case ruled appeals procedure patients without capacity detained section mental health act compatible article european convention human rights european court ruled special procedural safeguards required enable cohort patients exercise rights guaranteed article conclusions responsible clinicians treating consultant psychiatrists need ensure patients detained section mental health act assessment capacity apply tribunal need systems place alert hospital managers patient lacks capacity apply tribunal hospital managers request secretary state apply tribunal instances knowledge ruling relevant informing practice interdisciplinary healthcare professionals working patients
background mapping disease rates region provides visual illustration underlying geographical variation disease useful generate new hypotheses disease aetiology however methods fit popular widely used conditional autoregressive car models disease mapping feasible many applications due memory constraints particularly sample size large propose new algorithm fit car model accommodate individual group level covariates adjusting spatial correlation disease rates termed indicar method scales well works large datasets methods fail results evaluate performance indicar method simulation studies simulation results indicate indicar provides reliable estimates regression random effect parameters also apply indicar analysis data neutropenia admissions new south wales nsw australia analyses reveal lower rates neutropenia admissions significantly associated individual level predictors including higher age male gender residence outer regional area group level predictor social disadvantage socio economic index areas large value spatial dependence parameter estimated adjusting individual area level covariates suggests presence important variation management cancer patients across nsw conclusions incorporating individual covariate data disease mapping studies improves estimation fixed random effect parameters utilizing information multiple sources health registries routinely collect individual area level information thus could benefit using indicar mapping disease rates moreover natural applicability indicar distributed computing framework enhances application big data domain large number individual group level covariates nsw study reference number dated july
paper describes novel low profile antenna satellite digital audio radio service antenna consists thin cavity pair crossed slots unequal length slots fed single probe type feed resulting simple low cost structure antenna left hand circularly polarized toward sky satellite reception vertically polarizated toward horizon terrestrial reception result low profile antenna receive simultaneously satellite broadcasters terrestrial repeaters built using low cost printed circuit fabrication methods
obesity become increasingly prevalent number obese patients need liver transplant expected continue increase addition liver disease due nonalcoholic fatty liver disease expected become leading cause liver transplantation near future however obesity remains relative contraindication liver transplant new strategies managing patient population clearly needed end authors review current literature efficacy bariatric surgery setting liver transplantation obese patients
decline cognitive function elderly common represents major clinical public health concern aspirin may reduce decline cognitive function influencing multi infarct dementia data sparse east boston senior health project population based cohort study enrolled community dwelling residents aged years older followed home visits every years trained interviewers assessed cognitive function using short portable mental status questionnaire assessed medication use including counter drugs response short portable mental status questionnaire scored high medium low decline defined transition lower category participants used drugs containing aspirin weeks prior interview classified aspirin users multiple logistic regression used obtain adjusted odds ratios confidence intervals decline cognitive function estimating equation approach used adjust standard errors repeated measurements aspirin users odds ratio cognitive decline confidence interval low frequency aspirin use less daily associated odds ratio confidence interval although substantial effect observed data also compatible modest benefit aspirin especially intermittent use decline cognitive function concern small residual biases self selection confounding suggests randomized trials necessary provide definitive data question
need automated analyzers industrial environmental samples triggered research new cost effective strategies automation control analytical systems widespread availability open source hardware together novel analytical methods based pulsed flows opened possibility implementing standalone automated analytical systems low cost among areas benefit approach analysis industrial products effluents environmental analysis work multi pumping flow system proposed determination phosphorus effluents polluted water samples system employs photometric detection based formation molybdovanadophosphoric acid fluidic circuit built using three solenoid micropumps detection implemented low cost led photodiode photometric detection system whole system controlled open source arduino uno microcontroller board optimization timing ensure color development pumping cycle discussed proposed implementation experimental results evaluate system behavior presented verifying linear relationship relative absorbance phosphorus concentrations levels high
objectives growing number women chd presents unique challenges including related pregnancy lead significant morbidity mortality sought evaluate perception paediatric cardiologists towards reproductive health women chd methods paediatric cardiologists united states america invited participate cross sectional anonymous survey information solicited included knowledge contraceptive methods experience caring pregnant women chd referral patterns including utilisation high risk obstetric adult chdspecialists results total cardiologists responded academic affiliation years clinical experience although reported understanding available contraceptive options feel comfortable recommending birth control pregnant women chdwere seen responders responders reported low level comfort among respondents indicated would refer pregnant chd patient high risk obstetrician adult chd specialist almost respondents would transfer care non adult chd cardiologist among paediatric cardiologists indicated would resume patient care following delivery conclusion results illustrate gap physicians feel done care feel comfortable providing pregnant women chd population continues grow training adult chd cardiologists specific skills reproductive health women chd first step closing care gap exists management patients
review shows water biological systems passive liquid solvent also partner formation structure proteins nucleic acids complexes thereby contributing stability flexibility required proper function reciprocally biological macromolecules affect state water contacting partly normal liquid state somewhat ordered bound macromolecules compaction globular proteins results reluctance hydrophobic groups interact water collagen superhelix maintained water forming hydroxyproline controlled frame around coiled coil macromolecule dna stability rigidity linked water fixed pairs minor groove leads enthalpic contribution pairs exceeding pairs overbalanced greater entropy contribution result pairs melt lower temperatures gcs loss water drives transcription factor binding minor groove
work demonstrate technology wafer scale transistor level heterogeneous integration gaas pseudomorphic high electron mobility transistors phemts complementary metal oxide semiconductor cmos silicon substrate gaas phemts vertical stacked top cmos wafer using wafer bonding technique best alignment accuracy obtained circuit example wide band gaas digital controlled switch fabricated features technologies digital control circuit cmos switch circuit gaas phemt smaller area normal gaas cmos circuits
host defence peptides hdps short cationic amphipathic peptides play key role response infection inflammation complex life forms increasingly emerging hdps generally modest direct activity broad range microorganisms anti infective properties mainly due ability modulate immune response report recombinant production characterization two novel hdps identified human apolipoprotein residues using bioinformatics method recently developed group focused attention two variants identified hdp named apob apob residue long respectively hdps found endowed broad spectrum antimicrobial activity show neither toxic haemolytic effects towards eukaryotic cells interestingly hdps found display significant anti biofilm activity act synergy either commonly used antibiotics edta latter selected ability affect bacterial outer membrane permeability sensitize bacteria several antibiotics circular dichroism analyses showed sds tfe lps significantly alter apobl conformation whereas slighter significant effects detected case apobs peptide interestingly apob derived peptides found elicit anti inflammatory effects able mitigate production pro inflammatory interleukin nitric oxide lps induced murine macrophages also emphasized apobl peptide found play role human keratinocytes wound closure vitro altogether findings open interesting perspectives therapeutic use herein identified hdps elsevier inc rights reserved
existence formal water markets european context limited spanish case despite rationale deeply rooted economic literature italy formal water markets widely criticized supported national legislation however due specificity form water reallocation exists number rainwater harvesting reservoirs north italy aims analysis description institutional arrangement economic assessment reallocation mechanism including distribution gains formulate semi empirical mathematical programming model study outcomes different institutional scenarios results suggest reallocation increases gross margins area distribution gains favour water buyers despite inefficiencies institutional arrangement present area adds flexibility system likely face major changes next decades
auxiliary equation method presents wide applicability handling nonlinear wave equations article establish new exact travelling wave solutions nonlinear zoomeron equation coupled higgs equation equal width wave equation travelling wave solutions expressed hyperbolic functions trigonometric functions rational functions shown proposed method provides powerful mathematical tool solving nonlinear wave equations mathematical physics engineering throughout article calculations made aid maple packet program
process plants designed constructed engineering procurement construction companies order various types equipment installed equipment manufacturers design produce ordered equipment deliver customer therefore equipment information sharing important issue engineering collaboration plant project however use different three dimensional computer aided design systems different purposes reason additional three dimensional computer aided design data merging techniques required equipment information sharing article presents new approach share equipment information using three dimensional computer aided design simplification digital catalog techniques approach equipment three dimensional computer aided design data generated manufacturer first simplified converted neutral three dimensional computer aided design converted three dimensional computer aided design data merged port specification data digital catalog equipment information form digital catalog finally delivered engineering procurement construction companies
green building design presently among hottest research topics world maintaining comfortable indoor environment minimum energy consumption challenging task attracts attention experts around world recent advances building performance simulation tools possible predict assess building performance design stage simulation based optimization building design potential application connects building performance simulation optimization algorithms paper numerous studies optimization building envelope design assembled reviewed popular optimization algorithms compared discussed targeted objectives collected summarized based statistical results limitations research area identified potential breakthroughs suggested elsevier rights reserved
methods integrated computational materials engineering developed successfully applied aluminium constantly improved main aspects recent advances integrated material process modeling simulations material properties like strength forming properties specific microstructure evolution processing rolling extrusion annealing influence material constitution process variations production process final application examples discussed process simulation microstructures related properties aluminium sheet including ingot casting pre heating homogenization hot cold rolling final annealing new results included simulation solution annealing age hardening xxx alloys automotive applications physically based quantitative descriptions computer assisted evaluation methods new icme methods integrating new simulation tools also customer applications like heat affected zones welding age hardening alloys aspects estimating effect specific elements due growing recycling volumes requested also high end aluminium products also discussed special interest aluminium producing industries
discuss architecture functionality multiagent system supporting data integration based faceted query evaluation system ontology enhanced graph databases use ontology subset owl profile support user interactive query formulation set server agents cooperate one another query answering using ontological knowledge query rewriting deciding query propagations propose algorithms ensuring tractable complexity query rewriting query evaluation
article new algorithm encrypt data tcp data segment using novel chaotic random number generator developed first dynamic analyses chaotic system used made original pseudo random number generator prng new approach designed key series produced prng tested nist passed tests chaos based encryption performed tcp one fundamental protocols data communication following tcp data segments encrypted sender bit base key series produced prng decrypted receiver security level chaos based encryption carried tested histogram key length key sensitivity entropy method memory time usages measured performance analysis reveal performance encryption memory usage encryption decryption times analyzed comparison different security algorithms according tests analyses results chaos based encryption high level performance security original study used real time implementations tcp protocol copyright john wiley sons ltd
objective study identify characteristics andersson lesions using whole spine magnetic resonance imaging mri compared plain radiography ankylosing spondylitis total patients undergone whole spine mri plain radiography retrospectively enrolled study compared number discovertebral units dvus andersson lesions clinical radiographic indices erythrocyte sediment rate esr reactive protein crp bath ankylosing spondylitis disease activity index basdai bath ankylosing spondylitis functional index basfi modified stoke ankylosing spondylitis spine score msasss fifty three patients whole spine mri patients plain radiography least one andersson lesion found dvus andersson lesions mri dvus plain radiography spine levels andersson lesions mri commonly detected lower thoracic spine among total andersson lesions whole spine mri identified central disc type anterior peripheral disc type posterior peripheral disc type diffuse disc type however number andersson lesions correlate esr crp basdai basfi msasss study indicates presence andersson lesions patients clearly underestimated mri superior technique detecting early andersson lesions compared plain radiography
user authentication wireless sensor network wsn plays important role legal registered user allowed access real time sensing information sensor nodes inside wsn allow access user needs authenticated accessed sensor nodes well gateway nodes inside wsns resource limitations vulnerability physical capture sensor nodes attacker design secure user authentication wsn continues important challenging research area recent years paper propose new three factor user authentication scheme based multi gateway wsn architecture widely accepted burrows abadi needham logic prove scheme provides secure mutual authentication present formal security verification proposed scheme using avispa tool powerful validation tool network security applications show scheme secure addition rigorous informal security analysis shows scheme also secure possible known attacks including sensor node capture attack furthermore present additional functionality features scheme offers efficient communication computation copyright john wiley sons ltd
aimfew studies published children hereditary angioedema hae autosomal dominant disease caused mutations chromosome study explored various aspects disease swedish paediatric population methodsa retrospective questionnaire sent swedish children known hae physician carried follow telephone interviews resultsmost questionnaires completed parents children hae without input median age nine years range physician also interviewed hae symptoms experienced children including abdominal attacks skin swelling swelling mouth upper airways psychological stress common trigger abdominal attacks trauma sports triggered skin swelling majority access complement esterase inhibitor concentrate home current health quality life generally rated good independent whether child experienced hae symptoms conclusionmost children hae experienced abdominal attacks skin swelling overall health quality life generally perceived good
recollection constructive prone distortion mechanisms recollections become embellished rich yet illusory details still debated according conceptual fluency hypothesis abstract semantic conceptual activation increases familiarity nonstudied event causing one falsely attribute imagined features actual perception contrast according perceptual recombination hypothesis details actually perceived events partially recollected become erroneously bound nonstudied event causing detailed yet false recollection report first experiments aimed disentangling mechanisms participants imagined pictures common objects saw actual picture imagined objects next presented misinformation associated studied items designed increase conceptual fluency semantically related words perceptual recombination perceptually similar picture fragments finally tested recollection originally seen pictures using verbal labels retrieval cues consistent conceptual fluency processing related words increased false recollection pictures never seen consistent perceptual recombination processing picture fragments increased false recollection also found conceptual fluency short lived perceptual recombination dissociating mechanisms experiments provide strong evidence conceptual fluency perceptual recombination independently contribute constructive aspects recollection
although quite recent forensic research domain computer vision analysis scenes likely become important near future thanks robustness image alterations signal level image compression filtering however experimental assessment vision based forensic algorithms particularly critical task since tested massive amounts data performance heavily depend user skill paper investigate accuracy reliability vision based user supervised method estimation camera principal point used cropping splicing detection results extensive experimental evaluation show estimation accuracy depends perspective conditions well selected image features evidence led define novel visual feature referred minimum vanishing angle used assess reliability method elsevier inc rights reserved
early engineers drew heavily exemplars achievements past telford employment county surveyor involved restoration existing works however engineers often accused despoiling existing environment telford involved destruction precinct katharine tower london abundant examples railways showing scant concern heritage passed contrast engineers like benjamin baker francis fox used engineering skills extend life threatened structures frequent debate seeking improve existing infrastructure want improvements take account historic engineering heritage recent examples include strengthening brunel thames tunnel network rail improvement works manchester heritage successes often based committed individuals using engineering knowledge mount successful campaigns despite powerful analytical tools ever improving monitoring technology structures like internationally significant union suspension bridge threat may argue comes money part result engineers education lack knowledge heritage sense place
detection negative emotions daily activities writing drawing useful promoting wellbeing spread human machine interfaces tablets makes collection handwriting drawing samples easier context present first publicly available database relates emotional states handwriting drawing call emothaw emotion recognition handwriting drawing database includes samples participants whose emotional states namely anxiety depression stress assessed depression anxiety stress scales dass questionnaire seven tasks recorded digitizing tablet pentagons house drawing words copied handprint circles clock drawing one sentence copied cursive writing records consist pen positions paper air time stamp pressure pen azimuth altitude report analysis database collected data first compute measurements related timing ductus compute separate measurements according position writing device paper inair analyze classify set measurements referred features using random forest approach latter machine learning method based ensemble decision trees includes feature ranking process use ranking process identify features best reveal targeted emotional state build random forest classifiers associated emotional state provide accuracy sensitivity specificity evaluation measures obtained cross validation experiments results showthat anxiety stress recognition perform better depression recognition
introduction physical inactivity major contributor increasing levels obesity serious medical conditions among children adolescents worldwide major factor increase lack awareness mothers regarding physical activity children aim current study aimed identify degree knowledge awareness saudi mothers regarding children physical activities useful improving physical education health programs eventually children health care materials methods total mothers attending vaccination clinic well baby women health clinic participated study questionnaire used assess awareness regarding results majority mothers agreed crucial role motivating children engage aware current recommendations conclusion awareness saudi mothers regarding children exceedingly low creating awareness children essential
aims compare efficacy safety low dose standard dose infliximab ifx induction maintenance treatment chinese patients intestinal behcet disease identify potential predictors corticosteroid free clinical remission week methods prospective trial conducted patients moderate severe active intestinal followed weeks ileocolonoscopic examinations done baseline week logistic regression model used assess predictors corticosteroid free remission week results primary end point steroid free remission week observed patients received low standard doses ifx respectively secondary end point mucosal healing rates week found low standard doses ifx clinical response rates week also similar groups week predicted steroid free clinical remission week conclusions low dose ifx effective safe induction maintenance therapy patients active intestinal week predicted clinical remission week
objective parental feeding practices shape children relationships food eating feeding embedded socioculturally values attitudes related food parenting however studies examined associations parental feeding practices migrant background design cross sectional study parental feeding practices restriction pressure eat monitoring assessed using child feeding questionnaire differences explored four sub samples grouped maternal place birth sweden nordic western europe eastern southern europe countries outside europe crude partly fully adjusted linear regression models created potential confounding variables included child age gender weight status mother age weight status education concern child weight setting malmo stockholm sweden subjects mothers representing seventy three countries mean age years non swedish background overweight obesity university education pre school children mean age years boys overweight obesity results non swedish born mothers whether european born non european born likely use restriction swedish born mothers nordic western european born mothers reported lower levels pressure eat compared mothers born eastern southern europe mothers born outside europe differences monitoring small among potential confounding variables child weight status concern child weight highly influential concern child weight accounted effect maternal origin restriction conclusions non european born mothers concerned children overweight likely report controlling feeding practices future research examine acculturative structural factors underlying differences feeding
background current literature suggests personality disorder comorbidity negatively contributes severity prognosis disorders however little literature devoted influence borderline personality disorder bpd objective present work study comorbidity personality disorders severe clinical sample patients bpd relationship global functionality methods sample patients severe borderline personality disorder included study clinical functionality measures applied order study comorbidity bpd disorders relationship functionality associations comorbid pds analyzed tests linear correlations results patients presented comorbidity pds almost half sample presented two pds cluster paranoid obsessive avoidant frequent cluster histrionic antisocial presence avoidant predicted worse functional outcome long term mann withney conclusions severely impaired bpd patients present greater comorbidity cluster pds comorbid avoidant personality disorder might negatively predict prognosis
october use federal older americans act funds health promotion disease prevention restricted administration aging criteria high level evidence based health promotion programs dissemination programs rural communities remains limited therefore strong need exists identify strategies facilitate program implementation sustainability objective study compare organizational readiness implementation strategies used rural communities achieved varying levels success sustaining evidence based health promotion programs older adults utilized qualitative multi site case study design analyze longitudinal experiences eight rural sites working implement evidence based health promotion program years multiple sources data interviews documents reports surveys site informed analysis used conventional content analysis conduct cross case comparison identify common features rural counties successfully implemented sustained target evidence based health promotion program readiness implement evidence based programs low baseline site leaders described needing secure additional resources program implementation sites successfully utilized six essential resources implemented sustained greater numbers workshops external partnerships agency leadership commitment ongoing source workshop leaders health promotion coordination tasks assigned specific staff organizational stability change team engagement six essential resources described study help rural communities assess readiness implement health promotion programs work secure resources necessary successful implementation
overactive bladder term used describe group lower urinary tract symptoms prevalent women particularly age overactive bladder often experience related physical psychological symptoms conditions report poorer quality life women many factors increase risk developing overactive bladder modifiable therefore lifestyle behavioral interventions first line treatments treatment options becoming available women research provides new information underlying pathophysiology overactive bladder nurses play major role screening assessment management women many seek help try self manage symptoms leading continuing cycle unpredictable urgency incontinence
poor success rates high levels dropout common features treatment anorexia nervosa using semi structured interviews study elicited views women recovered recovery anorexia nervosa received treatment results derived thematic analysis revealed women high degree dissatisfaction treatment perception treatment system overly focused driven food weight contrast women really wanted seen treated whole person real relationship therapist
background objectives young people social anxiety display poor social functioning unclear whether underscored difficulties key social cognitive abilities perspective taking examined whether increased social anxiety associated reduced accuracy perspective taking task whether relationship stronger particular periods within adolescence methods fifty nine adolescents aged years completed computerised director task social anxiety scale adolescence participants virtually move objects following either instructions given director see objects simple rule ignore certain objects results participants scored clinical cut social anxiety less accurate take perspective director account scoring cut yet performed similarly control trials preliminary analysis indicated poorer performance strongly associated social anxiety mid adolescence years limitations used previously measure online perspective taking underlying cognitive mechanisms fully elucidated extending findings using additional measures perspective taking would valuable conclusions adolescents higher social anxiety less accurate taking perspective computerised character suggestion relationship strongest mid adolescence replicated findings highlight importance addressing specific social cognitive abilities assessment treatment adolescent social anxiety published elsevier ltd
emotions play important role human interactions integrated computer system make human computer interaction hci effective affective computing innovative computational modeling detecting user emotions optimize system responses hci however trade recognition accuracy real time performance methods processing facial expressions human voice body gestures methods lack efficiency usability real world applications natural language processing electroencephalography signals accomplish reliable usable high performance system paper proposes intelligent hybrid approach recognize users emotions using easily accessible low computational cost input devices including keyboard mouse touch pad single touch touch screen display single touch using proposed approach system developed trained supervised mode artificial neural network support vector machine svm techniques result shows increase accuracy svm comparison currently existing methods significant contribution show new directions future research emotion recognition user modeling emotional intelligence
previous research repeatedly demonstrated importance culture cultural identification interpersonal understanding aimed apply ideas domain mental state reasoning theory mind thus investigated relationship acculturation inferring mental states people within across cultures measuring caucasian east asian participants accuracy inferring mental states ethnicity targets using reading mind eyes test expected caucasian participants showed significant ingroup advantage inferring mental states versus ethnicity targets variation according measures acculturation important east asian residents canada showed greater accuracy versus ethnicity targets accuracy caucasian targets increased function time lived canada experience interacting caucasians iii increased endorsement mainstream canadian values decreased endorsement heritage culture values results suggest cross cultural understanding may malleable acculturation cultural experience highlighting importance research people different cultural perspectives come understand subsequently ameliorate cross cultural misunderstanding elsevier ltd rights reserved
smart cities topic recently become topic number one agenda national international research development projects paper written motivation present various ideas experts professionals academic environment represent different scientific fields work telecommunications control engineering traffic engineering information communication technologies etc authors believe using case university zilina uniza multidisciplinary synergic character topic may emphasized sufficiently therefore special content form paper used based question answer pattern traditionally prepared papers usually follow one two possible lines integration dimension research mono thematically oriented one technology fully integrated approach socio technical dimension solution purely technical problems socio technical perspectives position human whole chain paper aims raise set key questions representing urgent problems today smart city agenda answers
groundwater recharge processes water rock interaction hydraulic connectivity aquifers galilee eromanga basins central queensland australia investigated using stable delta delta radiogenic isotopes dissolved methane concentrations complemented major ion chemistry central eromanga upper sequence galilee basins sub basins great artesian basin gab coal seams galilee basin currently explored potential commercial coal seam gas deposits order understand potential influence depressurisation coal seams required release gas adjacent aquifers detailed understanding recharge processes groundwater hydraulics basins prior development required different isotope systems used study provide different information specific processes example assessment delta ratios suggested carbonate dissolution one major processes controlling water chemistry within aquifers addition combined assessment delta delta major ion chemistry indicates transpiration primary process controlling solute concentration gab recharge area whereas evaporation appears less significant groundwaters galilee basin recharge area outside limits gab different groundwater within gab units difference attributed dissolution potassium bearing micas absent gab groundwater age estimates based ratios suggest steady increase along flow paths lack anomalous age estimates recharge areas deeper parts basin indicates evidence regional inter aquifer mixing based isotopes however dissolved methane concentrations groundwater chemistry near faults indicates potential mix gas water coal seams gab groundwaters suggesting may local influence faults gas water conduits elsevier rights reserved
monitoring cues image face pair eyes found increase prosocial behaviour several studies however studies found little support effect examined whether monitoring cues affect online donations charity manipulating emotion displayed number watchers cue type also include statistical controls range likely covariates prosocial behaviour using crowdsourcing internet marketplace amazon mechanical turk mturk participants completed survey given opportunity donate charity shown image prime none monitoring primes tested significant effect charitable giving contrast control variables culture age sex previous charity giving frequency predict donations work supports importance cultural differences enduring individual differences prosocial behaviour shows range artificial monitoring cues reliably boost online charity donation mturk
read interest article shanin fungal infection risk evaluation fire study aiming describe incidence ifd critical care units develop validate clinical risk prediction tool identify non neutropenic critically ill adult patients risk ifd investigators congratulated way collected huge amount data adult intensive care units icus managed fire database developed validated risk model however stated prediction model would help identify patients may benefit antifungal prophylaxis number randomized controlled trials rcts demonstrated beneficial effect antifungal prophylaxis empiric treatment terms incidence invasive fungal disease ifd mortality statement supported available evidence rcts recent cochrane systematic review including rcts evaluating prophylaxis pre emptive empiric antifungal treatment antifungal drugs non neutropenic critically ill patients showed significant effect mortality risk ratio confidence interval significant reduction risk invasive fungal infection ifi subgroup analysis type intervention antifungal prophylaxis associated significant mortality reduction significant reduction ifi systematic review update one cited manuscript published including rct patients
remains conflict literature lateralisation affective face perception studies reported right hemisphere advantage irrespective valence whereas others found left hemisphere advantage positive right hemisphere advantage negative emotion differences injury aetiology chronicity proportion male participants participant age number emotions used within perception task may contribute contradictory findings present study therefore controlled directly examined influence possible moderators right brain damaged rbd left brain damaged lsd healthy control participants completed two face perception tasks identification discrimination group differences facial expression perception according valence found across emotions rbd group less accurate group however rbd lbd group performance differ lack difference rbd lbd groups indicates hemispheres involved positive negative expression perception inclusion older adults well defined chronicity range brain damaged participants may moderated findings participant sex general face perception ability influence performance furthermore rbd group less accurate led group identification task tested two emotions performance two groups indistinguishable number emotions increased four six suggests task demand moderates study ability find hemispheric differences perception facial emotion elsevier inc rights reserved
software architecting activities discussed agile software development methods combination software architecting agile methods focus numerous publications however little literature approach software architecting agile projects education paper present approach introduction software architecting activities agile project course approach based literature sources tailored fit educational goals context approach applied two consecutive executions course observe improved understanding value architecting activities appreciation among students combination architecting activities agile development applied approach predominantly cases architecturally savvy product owner research required understand approach performs scenarios architecturally unsavvy product owners needs adapted scenarios also conclude research needed challenges architects face agile projects order better prepare students practice elsevier inc rights reserved
environmentally conscious manufacturing process ecmp become obligation environment society enforced primarily governmental regulations customer perspective environmental issues ecmp involves integrating environmental thinking new product development especially true computer aided design cad phase last phase design process stage choices done feature technology core cad phase used integrate environmental aspects also integrations realized cad systems computer aided manufacturing cam computer aided process plan capp product life management plm explored eco design products paper presents new methodology selection green manufacturing process based cad features cad cam capp plm integrations firstly present overview works using cad phase reduce environmental impacts manufacturing process secondly propose approach based selecting ecmp promote new simple eco design tool helps inexperienced eco designers finally case study considered validate proposed approach results commented
human action recognition har core technology human computer interaction video understanding attracting significant research development attention field computer vision however uncontrolled environments achieving effective har still challenging due widely varying nature video content previous research efforts trajectory based video representations widely used har although approaches show state art har performance various datasets issues like high computational complexity presence redundant trajectories still need addressed order solve problem real world har paper propose novel method har integrating technique rejecting redundant trajectories mainly originating camera movement without degrading effectiveness har furthermore order facilitate efficient optical flow estimation prior trajectory extraction integrate technique dynamic frame skipping result make use small subset frames present video clip optical flow estimation comparative experiments five publicly available human action datasets show proposed method outperforms state art har approaches terms effectiveness simultaneously mitigating computational complexity elsevier rights reserved
security game basic model resource allocation adversarial environments two players defender attacker defender wants allocate limited resources defend critical targets attacker seeks favorable target attack past decade surge research interest analyzing solving security games motivated applications various domains remarkably models game theoretic solutions led real world deployments use major security agencies like lax airport coast guard federal air marshal service well non governmental organizations among research applications equilibrium computation serves foundation paper examines security games theoretical perspective provides unified view various security game models particular security game characterized set system consists defender pure strategies defender best response problem viewed combinatorial optimization problem framework captures basic security game models literature including deployed systems set system arising various domains encodes standard combinatorial problems like bipartite matching maximum coverage min cost flow packing problems etc main result shows equilibrium computation security games essentially combinatorial problem particular prove set system following problems reduced polynomial time combinatorial optimization computing minimax equilibrium zero sum security games computing strong stackelberg equilibrium security games computing best worst defender nash equilibrium security games therefore hardness polynomial solvability problems implies hardness polynomial solvability others games mean class security games arbitrary payoff structures fixed set defender pure strategies shows complexity security game essentially determined set system view drawing connections important conceptual contribution paper
fifa world cup south africa generated extensive controversy spectators use african vuvuzela trumpet asked white american participants opinions vuvuzelas well attitudes towards variety racial ethnic minority groups including immigrants african americans latinos found less participants liked vuvuzelas less positively also tended feel toward minority groups furthermore respondents liked vuvuzelas least also less generally open change findings suggest vuvuzela controversy plastic trumpet also episode differential ingroup outgroup perceptions lack openness new things
aims review describe self management interventions used improve risk factor control stroke patients quantitatively assess effects following overall risk factor control lifestyle behaviour physical activity diet nutrition stress management smoking alcohol medication adherence medical risk factors blood pressure cholesterol blood glucose individual risk factors systematically searched pubmed psycinfo cinahl cochrane database systematic reviews databases september identify relevant randomized controlled trials investigating self management improve stroke risk factors self management interventions qualitatively described data included meta analyses fourteen studies included review model estimating effect averaged across stroke risk factors significant became significant four low quality studies removed smd subgroup analyses revealed significant effect self management interventions lifestyle behaviour risk factors smd medical risk factors medication adherence individual risk factor self management interventions significantly improved smd self management interventions appear effective improving overall risk factor control however high quality research needed corroborate observation self management greater effect lifestyle behaviour risk factors medical risk factors largest effect improving medication adherence
introduction interfering antibodies capable causing potentially misleading results automated thyroid hormone immunoassays case presentation report case year old female patient autoimmune hypothyroidism chronic replacement treatment levothyroxine presented years diagnosis thyroid function test showing increased level tsh high level interference laboratory serum free thyroxin test suspected due lack symptoms hyperthyroidism different immunoassay platform confirmed low result discrepancy two results explained presence antit autoantibodies conclusions antibody interference serum free thyroxine must considered clinical findings laboratory results show discrepancies
objective investigate whether number hyaluronic acid injections sodium hyaluronate hyalgan course therapy alters effectiveness reducing knee osteoarthritis pain data sources electronic databases including pubmed embase searched january november study selection included clinical studies evaluated effectiveness course weekly intra articular injections hyalgan treat knee pain also included clinical studies evaluating effectiveness week course food drug administration approved treatments knee pain twenty four studies identified comprising study participants treated cohorts data extraction determined effect sizes selected studies extracting knee pain scores control treatments meta regressions implemented determine whether number weekly injections course hyalgan therapy modified outcomes data synthesis pooled estimate relief baseline pain confidence interval week course hyalgan week course hyalgan findings meta analysis indicate relief knee pain week course hyalgan similar week course hyalgan pooled estimate relief baseline pain week course products also indicating pain relief week course hyalgan similar week course products conclusions statistical difference reduction knee pain week course hyalgan compared reduction knee pain week course hyalgan week course products findings demonstrate comparable knee pain relief achieved week course hyalgan control groups american congress rehabilitation medicine
forces acting single drag typed pick important parameters excavation machine design selection better prediction tool forces including cutting normal forces generally general model cutting forces proposed based theoretical models also general model normal forces proposed using ratio normal force cutting force subsequently effect relevant geometrical parameters cutting force discussed friction angle pick rock cone angle attack angle employed develop cutting force models conical picks rake angle friction angle pick rock included peak cutting force model radial picks finally peak mean cutting forces models conical picks peak cutting force model radial picks unrelieved cutting mode developed using principle component regression analysis ridge regression analysis based raw data linear full scale cutting test results show proposed regression coefficients equations reasonable physically empirical models used practical application developed introducing relevant modified coefficients considering tool wear relieved cutting complex shapes picks results show good agreement measured predicted cutting force sharp picks unrelieved cutting mode performance modified models using relevant modified coefficients would decreased certain extent however statistical valid according results test models work used preliminarily estimation tool forces acting drag typed picks elsevier ltd rights reserved
fault diagnosis hydro turbine governing system important operation hydropower station stability power grid order improve diagnostic accuracy efficiency novel fault diagnosis method based nonlinear output frequency response functions novel identification method nonlinear output frequency response functions proposed applied problem hydro turbine governing system fault diagnostics first nonlinear model hydro turbine governing system built fault diagnosis principles based nonlinear output frequency response functions also introduced disadvantages traditional identification method discussed novel identification method proposed nonlinear output frequency response functions according operation characteristic hydro turbine governing system finally simulation verification experimental studies presented demonstrate accuracy efficiency proposed fault diagnosis method results indicate proposed method simple practical fault diagnosis hydro turbine governing system
background migraine recognized one leading causes disability global burden disease study seriously affects quality patients life current treatment options ideal monoclonal antibodies calcitonin gene related peptide receptor cgrp mabs appear promising migraine considerably better effect safety profiles objective study systematically assess clinical efficacy safety cgrp mabs migraine therapy methods systematic literature search pubmed cochrane library baidu scholar performed identify randomized controlled trials rcts compared effect safety cgrp mabs placebo migraine regarding efficacy reduction monthly migraine days baseline weeks responder rates extracted outcome measures effects cgrp mabs regarding safety total adverse events main adverse events adverse events evaluated results found significant reduction monthly migraine days cgrp mabs placebo weeks smd weeks smd weeks smd responder rates significantly increased compared placebo significant difference total adverse events main adverse events including upper respiratory tract infection nasopharyngitis nausea injection site pain back pain obviously changed compared placebo control results showed significant increase dizziness cgrp mabs placebo conclusions meta analysis suggests cgrp mabs effective anti migraine therapy adverse reactions larger sample size rcts required verify current findings
paper presents concept software defined radio flexible front end design architecture system well possible application examples explained one specific scenario operation maritime frequency bands well known service automatic identification system ais captured dlr mission aisat chosen maritime application example results embedded solution ais sdr platform presented paper since increasing request performance maritime radio bands services like ais enhanced international association marine aids navigation lighthouse authorities iala new vhf data exchange service vdes shall implement dedicated satellite link paper describes sdr flexible front end used technology demonstration platform upcoming data exchange service
primary disposal mean municipal solid waste china landfill recognized one major threats surrounding surface water groundwater environment due emission leachate aim study determine impact leachate surface water groundwater environment region chang landfill located sichuan province china surface water groundwater sampled hydrochemical analysis three electrical resistivity tomography profiles conducted evaluate impact leachate groundwater environment several laboratory tests carried build relationship soil bulk resistivity void fluid resistivity results showed seasonal creek named longfeng creek crosses landfill site contaminated leachate concentrations cod bod chlorides surface water samples increased times groundwater quality surface loose sediments along valley deteriorated obviously landfill downstream area laboratory tests soil samples indicated resistivity value omega critical value whether groundwater loose sediments polluted groundwater site adjacent spillway landfill partially contaminated emission leachate groundwater contamination zones downstream landfill recognized shallow zones left bank right bank longfeng creek improved understanding groundwater contamination around landfill beneficial landfill operation groundwater environment remediation
aim paper present design implementation electric foot rehabilitation machine uses advanced risc reduced instruction set computer machine arm microcontroller based brushless bldc motor drive function electric foot rehabilitation machine help patients need physical therapy foot goal patients increased muscle strength rehabilitation system hardware software designed programmed proportion integration derivation pid control algorithm employed motor drive speed torque control user interface also developed implemented provide user friendly experience finally prototype foot rehabilitation machine built tested experimental results demonstrate feasibility integrity complete system elsevier ltd rights reserved
work addresses problem expedited design optimization decomposable compact microwave structures particularly impedance matching transformers approach proposed exploits structure decomposition bottom technique elementary building blocks transformer circuit interest first optimized respect specifications extracted conventional circuit design subsequently entire circuit optimized using previously obtained building block dimensions starting point optimization engine stage process adjoint based gradient search embedded trust region framework bottom approach turns critical reliability standpoint initial dimensions obtained optimized building blocks already result reasonably good characteristics entire circuit global search required find satisfactory design contrast direct adjoint based optimization entire circuit leads local optimum may satisfy imposed requirements time computational cost design process reduced compared direct optimization entire circuit building block optimization carried low dimensional search spaces using simpler less expensive electromagnetic models technique demonstrated using three section impedance matching transformer copyright john wiley sons ltd
paper uses data attendance award program implemented one five industrial laundry plants show complex costs corporate awards previously ignored literature show although attendance award direct positive effects employees previously punctuality problems also led strategic gaming behavior centered specific eligibility criteria award award program temporarily changed behavior award eligible workers habituate improved attendance furthermore show extrinsic reward award program crowded internal motivation employees previously demonstrated excellent attendance generating worse punctuality periods ineligibility novelly show attendance award program also crowded internal motivation performance tasks included award program workers average pre program attendance lost efficiency daily laundry tasks program introduction argue motivational spillovers result perceived inequity internally motivated workers previously unrewarded superior attendance contributions paper suggests even purely symbolic awards generate gaming crowding costs may spill important tasks
aim study analyze psychometric properties portuguese version inventory father involvement short form ifi respect factor structure reliability preliminary concurrent discriminant validity study confirm factor structure different sample study study men completed ifi translated version subgroup men also completed portuguese versions parenting stress index short form parenting styles dimensions questionnaire short form paternal involvement scale study men completed ifi translated version results confirmatory factor analyses study found portuguese ifi bifactor structure dissimilar original version specifically model depicting general factor first order factors confirmed omega hierarchical coefficients indicating ifi global score calculated interpreted structure confirmed study cronbach alpha reliabilities study global scale respectively moreover preliminary evidence scale concurrent discriminant validity results indicate measure suitable use portuguese context interpretable global score may useful tool research regarding positive aspects men parental involvement information may also relevant cross cultural studies
mirnas regulate expression target genes diverse cellular processes hence play important roles physiological processes including developmental timing patterning embryogenesis organogenesis cell lineage myogenesis growth control comparative expression analysis mirnas expressed longissimus dorsi muscle two prenatal stages days post conception dpc one adult stage days post natum german landrace pietrain pig breeds performed using custom designed array prenatal stages mir mir families significantly regulated dpc whereas mir mir overexpressed dpc abundance several mirnas increased adult stage compared dpc including mir mir mir mir mirnas breed specific mir mir families regulated pigs mir mir mir regulated pigs several pathways related muscle development enriched predicted targets differentially expressed mirnas dynamic expression breed associated regulation porcine muscle mirnas suggests functional role mirna mediated gene regulation muscle development phenotypic variations muscle traits elsevier rights reserved
due effort designing high efficient electric vehicles high speed traction drives frequently used nowadays different winding topologies rotor shapes cooling concepts studied enlarge efficiency power density application compact multi phase winding permanent magnet excited synchronous machine including active rotor cooling system provides opportunities meet high requirements traction drive contribution focuses construction characteristics engineered six phase motor potential increase machine performance integrated rotor cooling system
sexual health severely decreases age males older years erectile dysfunction common sexual disorder although physical psychological risk factors identified protective factors yet determined date study examined endocrine psychosocial factors parallel regard modifying effect age related increase two hundred seventy one self reporting healthy men aged years provided psychometric data sexual function set potential psychosocial protective factors saliva samples analysis steroid hormones proinflammatory cytokines around participants reported least mild form direct associations identified perceived general health emotional support relationship quality intimacy motivation steroid hormones proinflammatory markers moderation analyses association age revealed positive effects testosterone dehydroepiandrosterone dhea perceived general health emotional support intimacy motivation negative effect interleukin group differences older men without emerged dhea psychometric measures perceived general health emotional support satisfaction life intimacy motivation psychosocial endocrine parameters moderated association age sexual health perceived general health emotional support intimacy motivation relationship quality emerged psychosocial protective factors higher dhea lower interleukin levels also buffered age related increase
study examined third party listeners ability detect hellos spoken prevalidated happy neutral sad facial expressions average detection accuracies happy sad happy neutral sad neutral listening tests followed average vocal pitch differences two sets hellos tests detection accuracies chance reflecting significant pitch differences respective hellos detection accuracy chance reflecting lack pitch difference sad neutral hellos expected detection accuracy positively correlated theory mind participating tests likened act eavesdropping discussed evolutionary perspective unexpected negative correlation detection accuracy empathy quotient discussed respect autism research empathy pitch discrimination
area security hot issue computer technology past years network internet technology used various area many people want get information whatever want via internet however persons still trust technology method technique prevent attack unauthorized paper propose relational model network security research use topic model consider interrelation topic security characteristics
present study investigated profile based perspective six dimensions character strengths heart strengths heart self focused strengths heart others focused strengths mind strengths mind self focused strengths mind others focused strengths aim identifying optimal combination peterson character strengths second aim examine whether profile membership associated mental health markers predicted least two qualitatively distinct profiles would emerge heart strengths profile mind strengths profile also predicted heart strengths profile would strongly associated markers mental health mind strengths profile respondents age years completed measures assessing endorsement character strengths range mental health markers latent profile analysis identified optimal profile solution based six dimensions strengths emergent profiles profile low strengths profile mind strengths profile heart strengths profile high strengths expected profile membership significantly associated mental health markers notably strengths heart zest hope kindness contributed favorable presentations therefore cultivating strengths associated heart dimension might enhance mental health elsevier ltd rights reserved
techniques soil reinforcement geotextile easy economic solutions limit surface settlements embankments prone sinkholes design structures based understanding complex mechanisms tensile geosynthetic behavior vertical loading frictional interaction soil reinforcement load transfer mechanisms arching effect soil embankment recently significant progress made allowing improvement design methods taking account frictional sliding effects geosynthetic sheet anchorage areas local increase vertical stresses vicinity edges cavity nevertheless soil dilatancy load transfer mechanisms embankment formation cavity static cyclic loadings remains unknown additionally reinforced treated soil layer specifically studied focus soil embankment behavior void experimental studies conducted part fui research project geoinov sinkholes experimentally simulated granular embankments treated soil layers reinforced geotextiles void created device allows progressive formation circular cavity increasing diameter enables reproduction formation natural sinkholes void reaches size wide traffic loads applied top surface embankment formation cavity vehicle traffic loading dedicated instrumentation used measure dilatancy soil movement load transfer deformation geotextile surface settlement experimental results analyzed compared existing analytical methods improve existing analytical methods elsevier ltd rights reserved
background number dysregulated mirnas identified proposed significant roles pathogenesis type diabetes mellitus renal pathology alpinia oxyphylla shown significant anti inflammatory properties play anti diabetes role objective study detect alteration mirnas underlying anti diabetes effects oxyphylla extract aoe type diabetic animal model cbiksj results treatment aoe weeks led lower concentrations blood glucose urine albumin urine creatinine mirnas statistically identified differentially regulated aoe mice respectively compared untreated mice mirnas identified comparison groups mirnas verified quantitative real time pcr functional bioinformatics showed putative target genes mirnas associated several diabetes effects signaling pathways conclusions founding suggest potential aoe medicinal anti diabetes treatment changes expressions specific mirnas results provide useful resource future investigation role aoe regulated mirnas diabetes mellitus
background periaqueductal gray pag dysfunction recognized migraine altered dysfunction pag subregions totally detected aim study investigate altered functional connectivity pag subregions patients methods brain structural images resting state functional imaging fmri data obtained normal controls patients system seven subregions pag classified bilateral ventrolateral pag vlpag lateral pag lpag dorsolateral pag dlpag dorsomedial pag dmpag functional connectivity maps pag subregion calculated two sample test applied age sex covariables results bilateral vlpag left dlpag presented decreased functional connectivity subregions bilateral lpags right dlpag dmpag showed significant altered functional connectivity compared brain regions decreased functional connectivity mainly located bilateral prefrontal cortex pfc middle temporal gyrus primary motor area pma supplementary motor area sma right ventrolateral pfc vlpfc patients study disease duration positively related functional connectivity bilateral vlpag bilateral thalamus putamen left pallidum right medial orbitofrontal gyrus patients conclusion present study suggested dysfunction bilateral vlpag left dlpag presented functional evaluation pag subregions may help diagnosis understanding pathogenesis
incidence assay critical path working group reviewed current state hiv incidence assays helped determine critical path introduction hiv incidence assay time consortium evaluation performance hiv incidence assays cephia formed spur progress raise standards among assay developers scientists laboratories involved hiv incidence measurement structure conduct direct independent comparative evaluation performance existing hiv incidence assays considered singly combinations recent infection test algorithms paper report new framework hiv incidence assay evaluation emerged effort past years includes preliminary target product profile incidence assay consensus around key performance metrics along analytical tools deployment standardized approach incidence assay evaluation specimen panels evaluation collected large volumes characterized using novel approach infection dating rules assembled panels designed assess impact important sources measurement error incidence assays viral subtype elite host control viraemia antiretroviral treatment present specific rationale several innovations discuss important resources assay developers researchers recently become available finally summarize key remaining steps path development implementation reliable assays monitoring hiv incidence population level
suicidal ideation suicide attempts common latina adolescents white african american adolescents several health risk behaviors identified associated latina adolescent suicides however date study identified consistency stability risk behaviors time study utilized national youth risk behaviors survey estimate prevalence suicidal ideation suicide attempts health risk behaviors associated suicidal behaviors latina adolescents analysis found prevalence suicidal ideation suicide attempts varied significantly year study span decreasing increased analyses found health risk behaviors significantly associated suicidal ideation suicide attempts vary time stability health risk behaviors associated suicidal behaviors could useful school personnel identify early risk latina adolescents may benefit school community mental health resources
paper thermal performance textile samples photopyroelectric technique logarithm amplitude pyroelectric signal presented special case normalised pyroelectric signal relative empty pyroelectric sensor implemented order avoid experimental factor simplify final expression pyroelectric voltage addition simulated fault detector based microcontroller picfa order provide low cost protection lock amplifier obtained thermal parameters single jersey knitted fabrics made cotton cotton acrylic fibre acrylic fibre measured fitting theoretical curves experimental ones photopyroelectric amplitude signal according modulation frequency root measurements good agreement corresponding values extracted photopyroelectric phase signal reported literature values
purpose estimated real world costs bleeding related episodes bres adults primary immune thrombocytopenia itp methods retrospective cohort study used marketscan commercial claims encounters medicare supplemental coordination benefits databases identified adult patients diagnosed primary itp defined least outpatient claims separated days inpatient claim international classification diseases ninth revision clinical modification diagnosis code primary itp bre defined according combination diagnosis codes procedure codes indicating bleeding use rescue therapies costs estimated using total reimbursed amount received providers including pocket costs reimbursement insurance adjusted dollars findings patients bres identified mean age years patients women mean total reimbursement per bre significantly higher mean inpatient versus outpatient reimbursements mean bre reimbursements higher splenectomized patients compared nonsplenectomized patients however difference statistically significant mean reimbursement bres associated bleeding alone rescue therapy alone reimbursement bres included bleeding rescue therapy implications real world reimbursement rates bres adult patients primary itp substantial significantly higher values among patients requiring hospitalization bleeding events additionally trend toward higher reimbursement rates among splenectomized patients elsevier journals inc rights reserved
low voltage low power operational amplifier opamp using process temperature insensitive current source presented design methodology addition based current source opamp implementation using current source presented spice simulations carried gpdk technology supply results addition based current source opamp compared mosfet current source opamp proposed opamp shows better gain gbw mhz low power consumption
although previous studies investigated tour leadership styles tour leaders scale available evaluation purpose study develop reliable valid measurement assessing tour guiding styles perspective tour leaders roles following depth interviews content analysis sort method generated initial items twelve tour guiding styles extracted exploratory factor analysis tour leaders confirmatory factor analysis tour members performed identify validity item tour guiding styles scale study extends current knowledge tour guiding styles tour leaders provides foundation building future theoretical concepts related constructs scale provides useful tool tour leaders measure guiding styles furthermore results serve reference travel agencies arranging tour leaders elsevier ltd rights reserved
early onset alzheimer disease eoad characterized greater nonmemory dysfunctions rapid progression greater hypometabolism atrophy late onset load sought investigate differences tau accumulation patterns early late onset patients mild cognitive impairment mci patients completed florbetaben positron emission tomography scans amyloid positive patients eoad eomci load lomci included study compared cortical binding patient group corresponding amyloid negative age matched controls contrast difference cortical binding eomci lomci groups eoad showed greater binding parieto occipital cortex load parieto occipital binding correlated visuospatial dysfunction eoad spectrum whereas binding temporal cortex correlated verbal memory dysfunction load spectrum findings suggest distinct topographic distribution tau may influence nature cognitive impairment eoad patients elsevier inc rights reserved
background even though united nation announced persons mental illness shall treated humanity respect inherent dignity human use coercion physical restrain still considered unavoidable managing abnormal behavior psychiatric patients information regarding magnitude contributing factors physical restrain among bipolar patients low income countries like ethiopia methods cross sectional study conducted amanuel mental specialized hospital may june among participants selected systematic random sampling technique data collected interviewing adjusted odd ratios aor confidence intervals used value considered statistically significant results prevalence physical restrain factors like two episodes aor history aggression aor comorbid illness aor use antipsychotic aor current use khat aor associated significantly conclusions prevalence physical restraint found high among bipolar patients needs public health attention
amongst side effects triptans substantial percentage patients experience injection site pain tenderness underlying mechanism unknown found dose range intradermal sumatriptan induced complex dose dependent mechanical hyperalgesia male rats distinct peaks hyperalgesia contrast females broad peak highest dose produce hyperalgesia either sex evaluated receptors mediating sumatriptan hyperalgesia males injection antagonist serotonin receptor subtype htb htd markedly inhibited sumatriptan induced hyperalgesia htd receptor antagonist completely eliminated hyperalgesia contrast females htd htb receptor antagonist completely blocked sumatriptan hyperalgesia htb htd receptor antagonists attenuated hyperalgesia females gpr estrogen receptor dependent selective htd htb agonists produce robust hyperalgesia female male rats respectively injected hyperalgesia induced sexes attenuated mechanical hyperalgesia induced sumatriptan dependent protein alpha subunit protein kinase pka positive negative nociceptors understanding mechanisms responsible complex dose dependence triptan hyperalgesia may provide useful information design anti migraine drugs improved therapeutic profiles ibro published elsevier ltd rights reserved
study examines rates morbid mental disorders indicators course illness among individuals bipolar disorder cannabis use disorders cud data drawn national epidemiological survey alcohol related conditions nesarc wave nationally representative sample adults living united states among individuals lifetime prevalence bipolar disorder rates cud past months compared general population logistic regression models adjusting sociodemographic variables indicated individuals bipolar disorder occurring cud increased risk nicotine dependence adjusted odds ratio aor alcohol aor drug aor use disorders well antisocial personality disorder aor compared without cud among individuals occurring cud age onset bipolar disorder significantly lower median number manic hypomanic depressive episodes per year significantly greater compared individuals without cud occurring cud associated significant morbidities severe course illness among individuals bipolar disorder comprehensive evaluation patients bipolar disorder include systematic assessment cud elsevier ireland ltd rights reserved
along food manufacturers retailers contribute directly national diet efforts reformulate private label products assessed little research considers voluntary initiatives impact public health explore efforts targeting children health nutrition making use corporate social responsibility reports seven leading retailers examine types actions retail chains retailers reported initiatives promoting children nutrition education physical activity schools since references programs decreased shift toward child wellness find retailers differ approaches commitment larger market shares mention initiatives frequently activities related nutrition education developing cooking skills promotion physical activity product reformulation research suggests efforts coordinated might misplaced persist time
activity recognition elderly person used provide information intelligent services health care professionals carers elderly people families elderly people remain homes independently study investigates use contribution wrist worn multisensors activity recognition found accelerometers important sensors heart rate data used boost classification activities diverse heart rates propose genetic algorithm based fusion weight selection gafw approach utilizes find fusion weights possible classifier combinations fusion methods study shows times gafw achieve equal higher accuracy best classifier within group
artificial intelligence technique back propagation neural networks used assess slope failure site slope failure data south cross island highway southern taiwan used test performance neural network model numerical results demonstrate effectiveness artificial neural networks evaluation slope failure potential based five major factors slope gradient angle slope height cumulative precipitation daily rainfall strength materials
paper consider deformed ads background study effect deformation parameter pair production rate schwinger effect electrostatic potential important pair production holographic schwinger effect paper analyze electrostatic potential deformed ads background investigate effect deformation parameter may useful test ads qcd case zero temperature find larger value deformation parameter leads smaller value separation length test particles probe also find finite maximum separation length presence modification parameter
study explored stereotype constructions people may impute others context contagious disease epidemic participants undergraduate students large university johannesburg south africa completed open ended build character questionnaire described typical person south africa currently believed particular risk hiv infection data thematically analysed interpreted seven themes resulted based stereotyping marginalised groups south africa considered higher risk hiv due historical disadvantage blacks women poor social cognitive framework explains stereotypes apply perceived groups carry risk undermine public health interventions regarding hiv pandemic south africa across population segments
many apprehensive mental health care potentially affects engagement recovery processes well health outcomes article introduces tool assess fear adverse mental health treatment experiences client perspective sample adults receiving mental health services community agencies study initial exploration validity scale assessing fears associated commonly experienced coercive disorganized interventions factor analyses supported construct validity item fear adverse treatment experiences scale significantly discriminates based upon service characteristics gender history victimization past experiences coercive disorganized interventions higher levels fear reported users traditional mental health services former inpatients voluntary admission status changed males people history childhood abuse people certain forms criminal justice involvement
traumatic ankle injury frequent clinical presentation ankle taping commonly used prophylaxis sprains adjunct rehabilitation ankle injury mechanisms behind taping remain unclear however one possible mechanism improved proprioception peroneal reflex responses study investigated peroneal reflex response rapid inversion using trapdoor different taping protocols dominant leg healthy subjects tested three conditions taping simple prophylactic taping circumferential leg taping repeated measures anova revealed statistically significant effect across conditions trials results suggest neurophysiological responses sudden inversion altered mechanical sensory input taping normal subjects
decomposed granite roadcuts difficult revegetate losing topsoil vegetation cover developed new drilling machine digger efficiently drill six holes simultaneously decomposed granite roadcuts facilitate revegetation digger consists base machine level excavator mounting body six hydraulic motors instead bucket tested performance two roadcuts southwest korea using time motion studies showed digger drill decomposed granite roadcuts daily unit cost digger less half roadcut stabilization revegetation techniques korea making digger cost effective revegetation technology field germination growth tests also conducted identify appropriate diameter depth drilling holes suitable revegetation species mulching treatment drilled holes three different diameters depths filled holes mixture plant seeds cultivated soil applied mulching treatments coir geotextile shade net mulching measured germination growth results two field plots month year results showed drilling diameter depth large enough result better plant germination growth erosion control species poa pratensis eragrostis curvula schrad nees survived grew better native woody species coir geotextile improved plant germination growth time motion revegetation results show digger promising technology restore decomposed granite roadcuts copyright john wiley sons ltd
wind tunnel study improvement aerodynamic stability simplified suspension bridge girder structures conducted using scaled section model objective study development economically superior suspension bridge center span length wind tunnel test showed edge girder type cross section exhibited large amplitude torsional vortex induced vibration well torsional flutter low wind speed accordingly aerodynamic countermeasures open grating deck triangular faring structural countermeasures center stay diagonal bracing mass increase tried improve aerodynamic stability finally feasibility best combination full scale bridge examined structural analysis higher education press springer verlag berlin heidelberg
study aims analyze relationships among types life stress smart mobile phone addiction life satisfaction university students taiwan subjects university students northern taiwan including males females research tools scale university students daily life stress scale smart mobile phone addiction scale university students life satisfaction data analyzed descriptive statistics product moment correlation analysis multiple regression analysis results suggested university students love affair stress academic stress positively influence smart mobile phone addiction stress interpersonal relationship stress self career family life stress time management issues significantly influence life satisfaction finally based findings suggestions proposed teachers university students future research
electromechanical impedance based structural health monitoring method attracted several researchers recent past aerospace civil mechanical timber biological structures smart materials piezoelectric lead zirconate titanate macro fibre composite transducers either surface bonded embedded inside host structure monitored smart materials applied input sinusoidal voltage interact structure sense measure process detect change selected variables stress damage critical locations categorized wire based advanced non destructive testing wireless based battery powered lead zirconate titanate macro fibre composite energy harvesting based self powered lead zirconate titanate macro fibre composite methods importantly effectiveness electromechanical impedance methods classified active passive based properties material component structure monitored furthermore also depend variables monitored interaction mechanism due surface bonding embedment article presents important developments monitoring path forward wired wireless energy harvesting methods related electromechanical impedance based structural health monitoring metals non metals
objective compare initial recurrent concussions regarding average number days concussions acute concussion symptoms symptom resolution time return play time setting participants high school athletes sustaining multiple concussions linked within sport seasons drawn large sports injury surveillance study design retrospective analysis longitudinal surveillance data measures number days concussions number symptoms endorsed specific symptoms endorsed symptom resolution time return play time results median time initial recurrent concussions days interquartile range days loss consciousness significant symptom difference occurred frequently recurrent initial concussions significant difference found number symptoms symptom resolution time recurrent concussions kept athletes play longer initial concussions recurrent concussions season ending conclusions found athletes initial recurrent concussions similar symptom presentations resolution time despite similarities athletes restricted returning play longer periods following recurrent concussion indicating clinicians managing recurrent concussions conservatively probable concussion recognition management superior compared previous studies published possibly improving recurrent concussion outcomes
background mutations gli similar glis gene encoding transcription factor glis rare cause neonatal diabetes congenital hypothyroidism reported patients date additional features previously described include congenital glaucoma hepatic fibrosis polycystic kidneys developmental delay facial dysmorphism osteopenia sensorineural deafness choanal atresia craniosynostosis pancreatic exocrine insufficiency case presentation report new case consanguineous parents homozygous novel mutation glis gene presented neonatal diabetes mellitus severe resistant congenital hypothyroidism cholestatic liver disease bilateral congenital glaucoma facial dysmorphism associated abnormalities external genitalia form bifid scrotum bilateral undescended testicles microphallus scrotal hypospadias might coincidental finding conclusions suggest infants neonatal diabetes associated dysmorphism screened glis gene mutations
background aimsthe clinical sequelae comorbidities alcoholic liver disease ald often require hospitalization aims study compare average costs hospitalizations ald costs hospitalizations alcohol related diagnoses involve liver estimate percentage difference costs ald non ald hospitalizations may attributed ascites protein calorie malnutrition conditions designthe national inpatient sample population based cross sectional database representing discharges community hospitals united states settingcommunity hospitals united states participantsthe sample included hospitalizations ald hospitalizations alcohol related diagnoses measurementsthe dependent variable total patient costs estimated contribution ascites protein calorie malnutrition conditions difference costs patients ald patients diagnoses findingsaverage costs ald patients higher patients diagnoses versus among conditions analysis protein calorie malnutrition largest impact costs confidence interval accounting higher costs ald stays conclusionscosts hospital care patients alcoholic liver disease higher patients alcohol related diagnoses increased costs associated specific clinical sequelae comorbidities protein calorie malnutritiona largely preventable conditionmaking substantial contribution
climate change increasing mean temperatures eastern mediterranean expected decrease annual precipitation resulting increase aridity may rapid adaptation tree species unless gene pool already possesses variation drought resistance vulnerability embolism estimated pressure inducing loss xylem hydraulic conductivity strongly associated drought stress resistance trees yet previous studies various tree species reported low intraspecific genetic variation trait therefore limited adaptive capacities increasing aridity quantified differences hydraulic efficiency xylem hydraulic conductance safety resistance embolism four contrasting provenances pinus halepensis aleppo pine provenance trial indirect evidence genetic differences results obtained three techniques bench dehydration centrifugation ray micro evidenced significant differentiation similar ranking provenances inter provenance variation correlated pit anatomical properties torus overlap pit aperture size results suggest adaptation halepensis xeric habitats accompanied modifications bordered pit function driven variation pit aperture study thus provides evidence appropriate exploitation provenance differences allow continued forestry halepensis future climates eastern mediterranean
many researchers highlighted scarcity empirical studies systematically examine advantages disadvantages use visualization techniques software understanding activities studies crucial gathering analyzing objective quantifiable evidence usefulness proposed visualization techniques tools ultimately guiding research software visualization paper presents controlled experiment aimed assessing impact graph based visualization technique comprehension tasks six common comprehension tasks performed undergraduate software engineering students completion time accuracy participants responses measured results indicate one hand use graph based visualization increases correctness average hand reduce completion time program comprehension tasks
voltage inverters common kind actuator interface variable frequency electrical systems usually driven modulation block provides gating signals switches direct digital control avoids modulation block gating signals directly produced controller configuration control electrical system discrete time quantized actuation problem paper analyzes harmonic content sinusoidal steady state resulting configuration analysis illustrates higher harmonic content providing lower bounds content case low ratios commutation fundamental frequencies also dependence harmonic content duty cycle commutation losses exposed findings apply different kind control structures regardless design tuning parameters experimentally compared two level three phase inverter used analysis relevance simplicity although procedure applied number phases levels international association mathematics computers simulation imacs published elsevier rights reserved
paper addresses realization anti stealth radar problems modern radars confronted application spread spectrum technology radars capability anti stealth anti jamming improved signal noise snr receiver increases raising launching power intercept probability decreases transmitting multiple codes range radar detector increases condition intercept probability unchanged simulation results show validity proposed method
present loss gain equalized reconfigurable section analog signal processor asp dynamic radio analog signal processing asp asp provides real time tunable group delay response pass transmission propose lumped loss gain implementation tuning equalization mostly easily achieved theoretical study derives transfer function fundamental characteristics device asp finally experimentally demonstrated first using single loss gain pair finally three cascaded loss gain pair structure full reconfigurability chirp chirp group delays shown illustration expected asp find wide applications asp systems requiring dynamic adaptability
abstract interpretation widely applied approximate data structures usually numerical value information combination needed effectively apply static analysis real software context introduce generic framework given heap value analysis combines proving formally soundness plug inside framework standard allocation site based pointer analysis tvla based shape analysis standard existing numerical domains far know first sound generic automatic framework statically typed object oriented programming languages combining heap value analyses allows summarize materialize heap identifiers elsevier rights reserved
background previous reports racial disparities treatment crohn disease african american patients shown differences medical surgical treatments population study thus far examined effect race outcomes surgery methods utilizing national surgical quality improvement program nsqip participant user file puf years examined effect race postoperative complications patients undergoing intestinal surgery results patients significantly higher rate complications overall compared non patients postoperative sepsis surgical site infection significant adjustment age sex preoperative disease severity lifestyle factors smoking race remained statistically significant factor postoperative complication rate additional adjustment made comorbidities american society anesthesiologists class race lose significance within model conclusion african americans experience greater amount postoperative complications following surgery crohn disease preoperative disease management addressing smoking status control comorbid disease important factors addressing racial disparities surgical treatment crohn disease
complex permittivity epsilon epsilon complex permeability microwave absorption properties ferrite polymer composites prepared different ferrite ratios polyurethane matrix investigated band ghz frequency range type hexaferrite composition baco prepared solid state reaction technique whereas commercial used prepare composites higher ghz frequencies ferrite permeabilities drastically reduced however forced conversion ions involves electron hopping could increased dielectric losses chosen composition measured complex permittivity permeability using vector network analyzer agilent model pna software module parameters epsilon epsilon found increase increased ferrite contents measured values parameters used determine reflection loss various sample thicknesses based model single layered plane wave absorber backed perfect conductor composite ferrite content shown minimum reflection loss power absorption ghz bandwidth extended frequency range ghz absorber thickness prepared composites fruitfully utilized suppression electromagnetic interference emi reduction radar signatures stealth technology elsevier rights reserved
pixel array sub thz detection pixel separately addressed integrated low cost cmos technology pixel comprises nmos incoherent power detection circuit high gain operational amplifier efficiency self mixing analyzed improved fet detector operational amplifier sequential pulse generator used design row column signal producing circuit pixel array measured peak responsivity ghz ghz comparison pixel without load resistor also characterized measured results show pixel load resistor efficiently increase pixel output
background recent studies associated positive emotions several variables learning coping strategies assertive behaviour concept gratitude specifically defined tendency recognise respond people situations grateful emotion unfortunately latin america validated measures gratitude different populations available aim study analyse psychometric properties gratitude questionnaire two chilean samples methods two studies conducted first high school adolescents women men ages ranging mean age second adults women men average age analysis psychometric properties scale determine validity reliability instrument chilean adolescents adults performed bivariate correlations multiple regression analyses exploratory factor analysis efa monte carlo simulations carried finally confirmatory factor analysis cfa performed results single factor solution found studies item version adolescents items adults factorial solution invariant across genders reliability adequate samples using cronbach alpha coefficient addition convergent discriminate validity assessed additionally negative correlation depression adolescents positive correlation happiness adults found conclusions suitable measure evaluating person disposition toward gratitude chilean adolescents adults instrument may contribute advancement study positive emotions latin america
background purpose study understand strategies employed families adopt acquired immune deficiency syndrome aids orphaned children adoptive families coping mitigating impact aids mbeya rural district tanzania high numbers aids orphaned children aged years mbeya region led increasing burden families caring understanding coping strategies impact mitigation activities employed adoptive families important order develop programmes help methods study employed qualitative method data collection one one depth interviews respondents included male female heads families provide essential care aids orphaned children mbeya rural district tanzania framework approach used analyse data collected july august results study findings revealed adoptive families faced several challenges including financial constraints due increased needs basic essentials health care expenses school fees food impacts adoptive families included shortage work opportunities limited time address challenges mitigate challenges adoptive families employed range coping strategies including selling family assets renting parts cultivable land extra cash task reallocation involved aids orphaned children entering labour force also employed strategy mitigate challenges involved enrolling children schools could take part income generating activities order earn supplementary family income creation additional income generating activities poultry farming coping mechanisms employed received support non governmental organisations ngos governmental organisations including isangati agricultural development organization local ngo local government respectively conclusions current study identified challenges adoptive families well aids orphaned children faced mbeya rural district tanzania recognition issues highlights need targeted interventions address underlying social determinants human immunodeficiency virus hiv aids affected populations order prevent imposition social cultural economic disadvantages families provide care aids orphaned children children findings may prove useful provoking discussions may lead hiv aids prevention development broader mitigation strategies alleviate impact scourge families communities rural tanzania similar settings across world
robots capable navigating performing tasks wide range environments yet systematic research relationship robot environments paper intention place context importance consideration environments robots creating intelligent living environment develop framework linking robots environments framework consists robot inclusiveness measures inclusive environment robot taxonomy classifies robot environment interaction five categories five design criteria guidelines support design evaluation autonomous robotic systems indoor outdoor environments elsevier rights reserved
physical model electrohydraulic actuation system obtained arrive closure model experimental models actuator friction characteristics proportional valves constructed variation discharge proportional valve shown metered ports nonmatched taken care estimating two separate coefficients main flow path one leakage coefficient algebraic friction model retaining features existing differential model developed nonlinear subsystem models integrated together matlab simulink frame predict actuation dynamics variations predicted experimental displacements piston different command signals found quite close
background hereditary angioedema hae caused deficiency functional esterase inhibitor cinh characterized recurrent episodes cutaneous mucosal submucosal tissue swelling affecting multiple anatomic locations previous studies demonstrated efficacy recombinant human cinh rhcinh acute hae attacks objective study evaluated efficacy safety rhcinh treatment multiple hae attacks open label extension study methods time onset symptom relief time minimal symptoms assessed using treatment effect questionnaire teq visual analog scale point ordinal scale investigator score results forty four patients received rhcinh single dose administered attacks median time beginning symptom relief based teq first attacks minutes ranging minutes median time minimal symptoms using teq first attacks minutes rhcinh well tolerated discontinuations due adverse events thrombotic anaphylactic events reported repeat rhcinh treatments associated neutralizing anti cinh antibodies conclusions single dose rhcinh effective improving symptoms hae attack sustained efficacy treatment subsequent attacks rhcinh positive safety profile throughout study study supports repeated use rhcinh time patients hae attacks authors published elsevier inc
paper presents circuit tungsten oxide based analog memristors post processed cmos based field programmable analog array integrated circuit fpaa fpaas powerful tools rapid analog experimentation prototyping power efficient computing allow custom analog circuits built reconfigured primary motivation work introduce demonstrate operation fpaa memristor hybrid circuit board level infrastructure form basis subsequent empirical work analog memristive computing experiments shown paper demonstrate successful fabrication memristors fpaa substrate usefulness hybrid computing infrastructure terms experimentation memristors experiments suggest single state variable capture adaptation memristor end spice compatible memristor model two state variables presented furthermore memristor based adaptive coincidence detector demonstrated fpaa memristor computing infrastructure
classification self inflicted skin lesions proposed european society dermatology psychiatry esdap group generated questions regard specific treatments could recommended cases therapeutic guidelines current paper integrate new psychotherapies psychotropic drugs without forgetting important relational characteristics required dealing people disorders management self inflicted skin lesions necessitates empathy doctor patient relationship based trust confidence cognitive behavioural therapy psychodynamic psychoanalytic psychotherapy alone combined careful use psychotropic drugs seem achieve best results difficult cases relatively new therapeutic techniques habit reversal mentalization based psychotherapy may beneficial treatment skin picking syndromes
pier scour caused flood waves analyzed introducing dimensionless effective work flow sediment bed around pier three parameter exponential function adopted relate normalized scour depth novel experimental installation able reproduce hydrograph high precision laboratory flume described used carry four series scour experiments order calibrate validate proposed relation first series consists experiments constant discharge advanced stages scour second third series experiments use single flood waves different shapes durations respectively fourth series consists scour experiments caused realistic flow hydrographs multiple peaks results show relation unique thus represents reliable concept prediction flood wave scour appropriately integrates effects hydrograph properties duration peak discharge shape scour proposed relation allows straightforward prediction maximum scour depth flood wave high precision good agreement measured computed scour observed cases american society civil engineers
scale kite powered system uses kites convert wind energy electrical energy studied determine performance characteristics establish feasibility steady state operation kite powered system kite connected tether transmits generated aerodynamic forces kite power conversion system ground ground based power conversion system consists rocking arm coupled sprag clutch flywheel electrical generator governing equations describing dynamical motion kite tether power conversion mechanism developed assuming inflexible straight line tether steady state analysis kite aerodynamics incorporated dynamical equations kite powered system governing equations solved numerically using runge kutta scheme assess performance parameters system output power cycle time tether tension varied wind speed kite area aerodynamic characteristics kite results showed scale system feasible using proposed design concept kite area wind speeds preliminary efforts build test working scale kite powered demonstrator also reported doi
purpose paper aims present new method real time monitoring thermal profiles applied vapour phase soldering vps reflow processes thermal profile setting significant variable affects quality joints method allows rapid achievement required thermal profile based software control brings new efficiency reflow process enhanced joint quality especially power electronics design methodology approach real time monitoring system based computerized heat control realized newly developed laboratory vps chamber using proportional integral derivation controller within soldering process principle lies strictly accurate monitoring real defined reflow profile reference findings accurate maintenance required reflow profile temperature achieved high accuracy degrees new method monitoring control reflow real time profiling verified various maximal reflow temperatures degrees degrees degrees method feasible reflowing three dimensional power modules use various types solders real time monitoring system based computerised heat control helped achieve various heights vapour zone originality value paper describes construction newly developed laboratory scale vps chamber including novel real time profiling reflow process based intelligent continuously measured temperatures various horizontal positions real time profiling laboratory vps chamber allowed reflow soldering power modules greater dimensions applying various flux less solder materials
breast cancer leading cause cancer related mortality among females worldwide angiogenesis plays crucial role progression hydroxycholesterol endogenous selective estrogen receptor modulator promotes growth metastasis found improved angiogenic ability vegf dependent manner molecular mechanisms one hand estrogen like factor enhanced expression vegf classical alpha vegf signaling positive cells hand positive negative cells enhanced generation ros turn activated stat vegf signaling independent manner either blocking generation ros knockdown stat attenuated induced autocrine vegf angiogenesis findings suggested mechanism whereby enhanced angiogenesis also helped recognize novel potential harmful factor especially menopause patients elsevier ireland ltd rights reserved
examine relationship viewing economic expectations economic recession content analysis hours local network primetime programming news nonnews identifies moderate bias toward economic pessimism broadcasts survey adult population points significant positive relationship viewing total viewing viewing news programming economic pessimism national personal levels similar relationship exists viewing optimistic biasthe tendency pessimistic economic matters national personal level results remain significant controlled demographics trust national institutions evaluation current economic situation consumption media corroborate second order cultivation effect economic context
two dimensional analytical drain current model developed delta doped tunnel field effect transistor tfet address current issues conventional tfet insertion highly doped delta layer source region paves way improved tunneling volume thus provides high drain current compared tfets present model takes account effects distance delta doping region source channel interface subthreshold swing current ratio current performance tfet predicted higher current ratio congruent compared tfets congruent reasonable similar dec vth performance optimal position channel surface potential electric field minimum tunneling distance derived using solution poisson equation accuracy tfet model validated using technology computer aided design tcad device simulator synopsys
emerging non volatile memory nvram technologies offer durability disk byte addressability dram devices allow software access persistent data structures directly nvram using processor loads stores however ensuring consistency persistent data across power failures crashes difficult atomic durable transactions widely used abstraction enforce consistency implementing transactions nvram requires ability constrain order nvram writes example ensure transaction log record complete marked committed since nvram write latencies expected high minimizing ordering constraints critical achieving high performance recent work proposed programming interfaces express nvram write ordering constraints hardware nvram writes may coalesced reordered preserving necessary constraints unfortunately straightforward implementation transactions interfaces imposes unnecessary constraints show remove dependencies variety techniques notably deferring commit locks released present comprehensive analysis contrasting two transaction designs across three nvram programming interfaces demonstrating speedup
main method early screening developmental dysplasia hip ddh ultrasound imaging several studies ultrasound imaging newborns hips studies include prenatal period life aim examine prenatal development hip joint evolution angle seen ultrasound described graf method combined anatomical dissection materials methods thirty one post mortem fetal hips analyzed trough anatomical dissection cases trough ultrasound imaging angle measured based morphometric examination applied sine rule calculated alpha angle also represents coverage femoral head results based morphometric examination diameters femoral head acetabulum also joint cavity showed increase development angles measured calculated alpha showed decrease fetus developed conclusions decrease angles alpha alpha increase joint cavity development correspond findings main research papers hip joint less stable perinatal life angle accurately determined ossification acetabulum started case fetus older weeks
diaper dermatitis major issue among hospitalized infants leading increased medical costs pain risk infection distress among patients caregivers evidence based algorithm prevention treatment diaper dermatitis developed introduced level neonatal intensive care unit nicu two cases discussed examples severe diaper dermatitis first case demonstrates final case severe diaper dermatitis since introduction algorithm second case demonstrates less severe equally frustrating case diaper dermatitis occurred practice using algorithm established need consistency prevention treatment diaper dermatitis paramount providing quality care number points within bedside care regimen breakdown consistency occurs adherence consistent evidence based treatment regimens potential decrease incidence severity diaper dermatitis high risk hospitalized infants initiation evidence based algorithm assist prevention treatment diaper dermatitis supported data number cases diaper dermatitis collected implementing algorithm information assist continued education pursuance investigation major skin injuries nicu patients importance surrounding infant skin care building awareness surrounding facets skin care vulnerable population demonstrate benefits quality outcomes care
large scale wireless sensor networks wsns order enhance network security crucial trustor node perform social milieu oriented routing target trustee node carry trust evaluation challenging social milieu oriented routing one end end quality trust qot constraint proved complete heuristic algorithms polynomial pseudo polynomial time complexities often used deal challenging problem however existing solutions guarantee efficiency searching hardly avoid obtaining partial optimal solutions searching process quantum annealing uses delocalization tunneling avoid falling local minima without sacrificing execution time proven promising way many optimization problems recently published literatures paper first time help novel approach configuration path integral monte carlo cpimc simulations based optimal social trust path ostp selection algorithm applied extraction optimal social trust path large scale wsns extensive experiments conducted experiment results demonstrate ostp outperforms heuristic opponents
sige bicmos tuner digital satellite audio radio applications realized using second zero dual conversion architecture autonomous agc channel decoder controlled agc single pll drives mixers resulting smaller die area lower power dissipation providing baseband output reduces receiver power due lower adc digital core operating frequency sdars tuner performance includes noise figure image rejection dbm input sensitivity current supply min die area
post fire forest regeneration strongly influenced abiotic biotic heterogeneity pre post fire environments including fire regimes species characteristics landforms hydrology regional climate soil properties assessing drivers key understanding long term effects fire disturbances forest succession evaluated multiple factors influencing patterns variability post fire boreal larch larix sibirica forest siberia time series remote sensing images analyzed estimate post fire recovery response variable across burned area results suggested burn severity water content primary controllers larch forest recruitment green vegetation cover defined forest recovery index fri fractional vegetation cover fvc respectively found high rate larch forest recruitment sites moderate burn severity severe burn preferable condition quick occupation vegetation included early seral communities shrubs grasses conifers broadleaf trees sites close water received higher solar energy summer months showed higher rate recovery types defined fri fvc dependent burn severity addition factors topographic variables pre fire condition important predictors post fire forest patterns results direct implications post fire forest management siberian boreal larch region
past decades scholars conducted research held discussions green building highlight vital significance addressing environmental economic social challenges recognized public attitudes views towards green building may affect application daily lives although studies consumers cognition rarely carried social problems related green building consumers basic understanding purchase intention social humanistic needs public attitudes behaviors rebound effects furthermore social acceptance therefore studied based three research methods including literature review questionnaire inductive analysis analysis following results obtained green building sustainable design quite important influence consumers decision making process general public maintains high regard advantages green building better ventilation lighting major benefit saving energy water second rated land construction material saving although general public familiar concept green building majority participants would pay green buildings standard building know environmental impacts iii green building limited energy performance oriented also user oriented social humanistic needs model thus well established based maslow hierarchy needs life cycle green building social humanistic needs show trend dynamics means social processes consumer engagement participation needs considered aspects conceptual design planning design operation maintenance improve users happiness productivity current user oriented solutions green building always based hypothesis consumers readily motivated prefer expensive goods reducing energy use really reflect preference influenced actions social acceptance analyzed fully gauge interest perspective people rebound effects post occupant building performance including energy performance human comfort indoor environmental quality greenhouse gas emission workplace productivity divided two stages present necessary establish appropriate samples methods parameters unbiased valid post occupant evaluation system addition social acceptance green building framework established based wustenhagen triangular model renewable energy innovation explorations social problems green building article expected provide healthy social basis development green strategy elsevier ltd rights reserved
continuous development higher education enterprise improvement scientific research conditions quality quantity large instruments equipment colleges universities greatly improved however problem low efficiency high quality resources well solved problems existed construction management utilization open sharing system large instruments colleges found allusion problems corresponding solutions doped importantly used reference construction opening sharing system large instruments colleges practice opening sharing system large instruments promotes effective utilization technological resources colleges making use advanced technology intensive operation humanized service networked management significant construction better open sharing system large instruments colleges paper taking harbin institute technology example summarizes process construction sharing platform large precise instruments analyzes problems construction eventually finds measures construct open sharing system large instruments colleges
recently low cost effective biosensing systems based advanced nanomaterials received key attention development novel assays rapid sequence specific nucleic acid detection electrochemical biosensor based reduced graphene oxide rgo modified disposable pencil graphite electrodes pges developed herein electrochemical monitoring dna also monitoring biointeraction occurred anticancer drug daunorubicin dnr dna first rgo synthesized chemically characterized using vis tga raman spectroscopy sem techniques quantity rgo assembling onto surface pge passive adsorption optimized electrochemical behavior rgo pges examined cyclic voltammetry rgo pges utilized electrochemical monitoring surface confined interaction dnr dna using differential pulse voltammetry dpv technique additionally voltammetric results complemented electrochemical impedance spectroscopy eis technique electrochemical monitoring dnr dna resulted satisfying detection limits respectively
studies found evidence playing violent videogames min people experience mean short term increase aggression hostility anger current research investigated whether players habituate longer realistic lengths play participants randomly assigned play game quake iii arena either min participants long condition showed smaller change state anger csa pre post gameplay short condition although reach significance change scores gamers novice players showed short gaming led larger increase anger ratings long gaming results violent videogame players analysed separately significant increase anger post gameplayirrespective length time playing results also supported hypotheses females would show significantly larger csa males participants previously unexposed violent videogames would show significantly larger csa exposed participants
new electronic interface inductive sensors presented proposed circuit basically current feedback operational amplifier cfoa based sinusoidal oscillator circuit circuit uses one externally connected inductor exploits advantage internal poles cfoa sinusoidal oscillation frequency mhz obtained using cfoa inductor inductance peak peak output voltage
sodium tanshinone iia sulphonate water soluble derivative tanshinone iia proven possess versatile biological properties pharmacological effect tracheal smooth muscle remains elusive paper presents study relaxant effect underlying mechanisms sodium tanshinone iia sulphonate mouse tracheal smooth muscle relaxant effect sodium tanshinone iia sulphonate evaluated mouse tracheal rings using mechanical recording system intracellular concentration measured primary cultured tracheal smooth muscle cells using confocal imaging system results showed sodium tanshinone iia sulphonate induced dose dependent relaxation mouse tracheal rings beta adrenoceptor epithelium independent manner pretreatment atp sensitive channel blocker glibenclamide partly attenuated relaxation response administration sodium tanshinone iia sulphonate notably inhibited extracellular induced contraction high kcl carbachol evoked elevation intracellular concentration also abrogated sodium tanshinone iia sulphonate tracheal smooth muscle cells conclusion tracheal relaxant effect sodium tanshinone iia sulphonate independent beta adrenoceptor airway epithelium mediated primarily inhibition extracellular influx via type voltage dependent channels partially activation atp sensitive channel results indicate potential therapeutic value sodium tanshinone iia sulphonate asthma treatment
paper propose theoretical framework analyze performance ultra wideband acquisition uwb system based energy detection ieee channel proposed framework enables calculate probability density function pdf square sum multipath components mpcs gain collected receiver averaged criteria particular expectation variance sum variant characterized approximately log normal distribution expressed closed form based cluster point process moreover calculating methods averaged criteria markov chain model signal flow graph clearly demonstrated different applicable scenarios proposed framework well consistent simulation results respect calculation method
mathematics education contemporary elementary schools mainly conducted conventional way giving lectures teacher would pass knowledge students giving lectures type one way teaching method prone cause poor learning achievement many researchers suggested use collaborative problem solving improve situation research proposed use digital pen learning system dpls collaborative problem solving improve learning achievement learning motivation conventional mathematics courses quasi experimental design adopted set teaching activities involved fourth grade students four weeks results research show learning achievement two experimental groups significantly better control group significant difference two experimental groups control group terms learning motivation significant difference three groups terms learning attitude elsevier ltd rights reserved
petroleum products used wide variety industries energy sources raw materials become major concern pollution terrestrial marine environments purpose study assess potential indigenous microbial isolates degradation diesel fuel two proficient bacterial strains among five isolated strains polluted soil industrial refinery studied isolates identified pseudomonas aeruginosa bacillus subtilis using biochemical tests rrna gene sequence analyses aeruginosa showed higher biodegradation efficiency subtilis shaking flask containing diesel contaminated water aeruginosa subtilis degraded total hydrocarbons respectively flasks containing diesel water biodegradation efficiency isolates decreased diesel contamination increased isolates showed significantly higher efficiency degradation short chain hydrocarbons days using aeruginosa removal efficiency hydrocarbons near hydrocarbons aromatic hydrocarbons removed therefore isolates showed high capability biodegradation diesel contamination refinery
mesoscale electromechanical systems find applications fields medical instrumentation soft robotics microscopy flexible electronics imagining paper implements printed circuit mems mems process fabrication pop flexure based mesoscale system exploits simplicity manufacturing techniques sheet metal operations laser cutting realize mechanism fabrication laminated delta robot prismatic actuation presented exemplify process working device actuation functional components linear guides stepper motors limit switches designed fully realized mechanism popped plane achieve shape present stiffness analysis arrive plane pop angles planar system must accommodate constraints limits actuator torque force satisfied producing operational system simplicity processes makes candidate use emerging open source hardware technologies fabricating low cost complex electromechanical systems society manufacturing engineers published elsevier ltd rights reserved
challenging yet desirable quantitatively control expression target gene practice design device proportional biological operational circuit bom incorporating gate operational amplifier one circuit explore behaviors simulation results imply possible regulate input output proportionally manipulating rbs hrpr hrps tetr output gene used sensing environmental weak signals dioxins
purpose explore lean add value schematic phase design providing additional resources support project leadership architectural design team background case study based research took place one large academic hospital design efforts surgical tower house operating rooms ors support spaces including pre post central processing distribution materials management surgical services project leadership asked lean practitioners support design process methods lean exploration loops lels conducted generate evidence support stakeholders made important decisions new building design analyses conducted lels schematic phase primarily conducted using express workouts ewos focused flow patients staff family throughout pavilion results lels resulted recommendations key design features number pre post bays per floor location doors scrub sinks stretcher alcoves equipment storage sterile core areas two sided pre post bays inner clinical workspace outer patient transport corridor recommended communicating elevator centrally located stairwell staff alleviate stress main bank elevators peak usage times also suggested conclusions found lean tools methods value schematic phase focused detailed process layout analysis acknowledging usefulness focused ewos generate evidence needed decision making
popularization application internet technology brought great opportunities challenges significant change various industries entered internet age computer network double edged sword bringing convenience people time security risks seriously affecting information security internet age therefore article explore main computer network security risks lower risks computer security management measures thus providing important guarantee computer network security
introduction fingolimod sphingosine phosphate receptor modulator decreases annual relapse rate arr relapsing remitting multiple sclerosis rrms aim study assess efficacy safety daily practice patients rrms previously treated natalizumab systematically followed least year methods data collected patient files primary endpoint comparison arr year onset years treatment secondary endpoints difference expanded disability status scale edss onset years treatment safety results whole sample confirmed efficacy arr year two groups without arr higher group first year similar second year edss stable first year significantly higher years concerning safety three patients discontinue tolerance issues conclusion study showed safe rrms used either first line treatments however observed mild disability progression years
recent years upconversion material attracted much attention fantastic energy transfer capability converting low energy photons high energy photons via anti stokes process among materials visible materials exhibit remarkable potential laser conversion photo catalysis sterilization well antibiosis biological areas capability converting visible radiation ultraviolet emission considering interesting process large potential application visible materials necessary overview intrinsic mechanism material structure well material synthesis techniques development material work focus visible materials review current research situation challenges research field well analyzing comparing recent investigations provide valuable evaluation materials theoretical commercial perspective effective matrix luminescent centers recent works summarized intrinsic mechanisms visible introduced material design strategies techniques synthesis visible phosphors focused advantages limitations visible material discussed detail reasonable expectation emerging trends potential material provided elsevier rights reserved
background cannabis soon become legalized canada currently unclear impact public health methadone maintenance treatment mmt common pharmacological treatment opioid use disorder oud despite documented effectiveness large number patients respond poorly experience relapse illicit opioids studies implicate cannabis use risk factor poor mmt response although well established substance use behaviors differ sex studies considered sex potential moderator current study aims investigate sex differences association cannabis use illicit opioid use cohort mmt patients methods multicentre study recruited participants mmt oud canadian addiction treatment centre sites ontario canada sex differences association cannabis use illicit opioid use investigated using multivariable logistic regression secondary analysis conducted investigate association heaviness cannabis use results study included men women oud receiving mmt cannabis use significantly associated illicit opioid use women heaviness cannabis use associated illicit opioid use men women conclusions largest study date examining association cannabis use illicit opioid use cannabis use may sex specific predictor poor response mmt women likely use illicit opioids also use cannabis treatment women may show improved treatment outcomes cannabis use addressed mmt
objectives determine whether serum concentration hydroxy vitamin associated depression levels people chronic spinal cord injury sci whether observed association independent potential confounders design cross sectional study setting rehabilitation institute participants patients chronic sci recruited consecutively interventions applicable main outcome measures patients underwent clinical biochemical evaluations including assessment levels presence severity depressive symptoms using interviewer assisted self report beck depression inventory bdi results depression bdi score observed women men study population exhibited significantly lower levels lower functional independence degree performing activities daily living poorer engagement leisure time physical activity higher body mass index lower levels associated higher bdi scores well occurrence depression associations persisted adjustment significant predictors bdi score selected possible confounders univariate analysis receiver operating characteristic analysis level highest accuracy discriminating patients depression conclusions people chronic sci inverse association exists serum levels depressive symptoms widely independent potential confounders especially peculiar population mediate effects depression vitamin levels american congress rehabilitation medicine
software defect prediction predicts fault prone modules tested thoroughly thereby limited quality control resources allocated effectively without sufficient local data defects predicted via cross project defect prediction cpdp utilizing data projects build classifier software defect datasets class imbalance problem indicating defect class much fewer instances non defect class unless defect instances predicted correctly software quality could degraded context classifier requires provide high accuracy defect class without severely worsening accuracy non defect class class imbalance principle seamlessly connects purpose multi objective optimization predictive models aim balancing many competing objectives paper target identify effective multi objective learning techniques cross project environments three objectives devised considering class imbalance context first objective maximize probability detection second objective minimize probability false alarm third objective maximize overall performance balance propose novel naive bayes learning techniques modeled harmony search meta heuristic algorithm approaches compared single objective models existing models within project defect prediction models experimental results show proposed approaches promising result effectively applied satisfy various prediction needs settings elsevier rights reserved
backgroundthe severity bronchial hyperresponsiveness bhr fundamental feature asthma severity bhr varies asthmatics associated lack asthma control mechanisms underlying trait still unclear study aimed identify genes associated bhr severity using genomewide association study gwas slope bhr adult asthmatics methodswe performed gwas bhr severity adult asthmatics dutch asthma gwas cohort adjusting smoking inhaled corticosteroid use verified results three cohorts furthermore performed eqtl expression analyses lung tissue resultsin discovery cohort one genomewide significant hit located phosphodiesterase camp specif pded snps values found none findings replicated adult childhood replication cohorts jointly adult cohorts separately pituitary tumour transforming interacting protein pttgip mastermind like maml replicated nominally minor alleles associated less severe bhr higher lung tissue gene expression pttgip showed significant expression pituitary tumour transforming binding factor pttglp vimentin cadherin maml expressed significantly mastermind like maml involved notch signalling conclusionspttgip maml associated bhr severity adult asthma relevance genes supported eqtl analyses expression pttglp vimentin cadherin maml maml
large scale initiatives expand evidence based practices often poorly implemented rarely endure purpose study identify perceived barriers facilitators sustainment evidence based supported employment program individual placement support ips within year prospective study sustainment among ips programs states participating national learning community interviewed ips team leaders coded responses semi structured interviews using conceptual framework adapted another large scale implementation study leaders agencies sustained ips programs identified funding prioritization workforce characteristics key facilitators barriers additional key factors lack local community supports barrier leadership structured workflow facilitators within ips learning community team leaders attributed sustainment program funding prioritization workforce agency leadership structured workflow actions learning community leadership state governments local programs together may contributed high sustainment rate
evidence indicated positive association subclinical hypothyroidism sch cardiovascular diseases relationship sch chronic kidney diseases ckd remains unclear case control study performed ascertain relationship followed meta analysis hospital based case control study recruited type diabetic patients euthyroidism type diabetic patients sch english studies searched upon relationship sch ckd october meta analysis performed using stata software case control study indicated association sch ckd patients type diabetes five observational studies reporting risk ckd sch individuals enrolled significant relationship sch ckd shown pooled among normal tsh range individuals tsh significantly higher rate ckd fisher exact test dose response linear increase ckd events explored pooled per miu increase tsh present evidence suggests sch probably significant risk factor ckd linear trend shown tsh elevation ckd relationship serum tsh renal impairment type diabetic patients needs studies investigate
background role erectile dysfunction coupled low testosterone levels early markers atherosclerosis well understood objectives analyze relationship serum testosterone levels brachial artery flow mediated vasodilation fmd primary prevention sample men methods enrolled asymptomatic intermediate risk patients according framingham risk score aged years underwent ultrasound examination fmd evaluation assessment total serum testosterone levels results testosterone levels correlated fmd iief score multivariable logistic regression analyses revealed lower serum testosterone levels strongly associated severe moderate impaired fmd percentages strongly associated severe moderate mild moderate mild resulted statistically associated lower fmd serum testosterone levels relations substantially affected adjustments potential confounders including smoking status hypertension diabetes mellitus body mass index conclusions lower total serum testosterone levels associated impaired fmd sample intermediate risk men according framingham risk score elsevier ireland ltd rights reserved
increase international freight commerce creating pressure existing transport network cooperation different transport parties terminal managers forwarders transport providers required increase network throughput using infrastructure intermodal hubs locations cargo stored switch transport modality approaching final destination decisions regarding cargo assignment based cargo properties cargo properties fixed destination volume weight time varying remaining time due time goods expiration date intermodal hub manager access certain cargo information promote cooperation among different transport providers pick deliver cargo hub paper cargo evolution intermodal hubs modeled based mass balance taking account hub cargo inflows outflows plus update remaining time cargo due time using model written state space representation propose model predictive approach address modal split aware cargo assignment problem msa cap msa cap concerns cargo assignment available transport capacity final destination reached time taking consideration transport modality used model predictive approach anticipate cargo peaks hub assigns cargo advance following push cargo towards final destination approach addition modal split constraint possible guide daily cargo assignment achieve transport modal split target defined period time numerical experiments illustrate validity statements elsevier ltd rights reserved
bone marrow oedema bmo syndrome describes painful condition increase interstitial fluid within bone often lately diagnosed due unspecific symptoms underlying causes diverse widely assumed cases bmo local bone resorption increased denosumab human monoclonal antibody binds receptor activator nuclear factor kappa ligand rankl inhibits osteoclastic bone resorption commonly administered treatment osteoporosis besides one previous case report clinical effectiveness treatment bone marrow oedema elucidated treated patients primary idiopathic bone marrow oedema lower extremity single dose denosumab application mean time onset pain therapy days mri scans performed initial diagnosis weeks denosumab injection vitamin calcium homeostasis strived balanced initiation therapy furthermore bone status analysed using dual energy ray absorptiometry dxa extended bone turnover serum markers weeks bmo dissolved partly completely complete recovery observed individuals visual analogue scale vas evaluation revealed significant decrease pain level furthermore bone turnover decreased significantly treatment adverse reactions reported conclusion retrospective analysis shows denosumab highly effective treatment bone marrow oedema therefore represents alternative treatment option elsevier ltd rights reserved
aims objectives explore sleep quality infertile women examine factors contribute sleep disturbances intrauterine insemination treatment background sleep disturbance important factor human health well sleep disturbances tend occur among infertile women intrauterine insemination treatment although many studies focused high percentage somatic symptoms psychological distress infertile women associated treatment studies investigated factors linked sleep disturbances design cross sectional study methods study conducted period september january teaching hospital taiwan infertile women received assisted reproduction intrauterine insemination treatment completed questionnaire demographic data somatic symptoms psychological distress perceived sleep quality collected results one third infertile women reported sleep disturbances nausea symptoms psychological distress risk factors contributed sleep disturbance conclusions variables nausea psychological distress significantly explained sleep disturbances infertile women evaluation nausea symptoms psychological distress among infertile women important area future research research aim identify best compromise infertility treatment sleep quality relevance clinical practice clinical obstetrics gynaecology nurses develop strategies help infertile women reduce nausea symptoms psychological distress intrauterine insemination treatment promote healthy sleep
water crucial resource west africa large parts population rely rainfed agriculture therefore accurate knowledge water resources utmost importance due declining number rain gauging stations use satellite reanalysis precipitation datasets hydrological modelling steadily rising however accurate information benefits deficits datasets often lacking especially west african subcontinent validation purposes products commonly compared freely available rain gauge data cases already used bias correct products first place therefore explored possibility hydrological evaluation model calibrated dataset using streamflow observed variable study ten freely available satellite reanalysis datasets cfsr chirps cmorphv crt cmorphv raw persiann cdr rfe tamsat tmpa tmpa rtv gpcc fddvl thus evaluated six differently sized located basins west africa results show performances differ datasets manage somewhat accurately predict observed stream flow given basin best results achieved datasets use multitude input data namely infrared microwave satellite data well observations rain gauges usually gpcc bias correction considering nash sutcliffe efficiency averaged six basins calibration phase best results achieved cmorph crt persiann cdr followed tamsat chirps tmpa three average results achieved rfe gpcc tmpa cmorph raw cfsr performed worst average elsevier rights reserved
non alcoholic fatty liver disease nafld currently common form liver disease worldwide affecting ages ethnic groups become consistent threat even young people aim estimate effect low glycemic index mediterranean diet lgimd nafld score measured liver ultrasonography lus nutrizione epatologia nutriepa population based double blind rct data collected analyzed men women coming putignano puglia southern italy drawn previous randomly sampled population based study identified moderate severe nafld intervention strategy assignment lgimd control diet main outcome measure nafld score defined lus randomization subjects assigned lgimd control diet study lasted six months participants subject monthly controls checks adherence lgimd measured mediterranean adequacy index mai showed median negative interaction time lgimd nafld score observed became evident sixth month positive effect interaction among lgimd time age third month sixth month also observed lgimd found decrease nafld score relatively short time encouraging subjects seek medical attention still nafld follow lgimd life style interventions may reduce degree severity disease dietary intervention kind could also form cornerstone primary prevention type diabetes mellitus tdm cardiovascular disease
background united states million informal caregivers provide unpaid care people alzheimer disease compared others age group caregivers higher rates stress medical psychiatric illnesses psychosocial interventions improve health caregivers however constraints time distance availability inhibit use services newer online technologies social media online groups friendsourcing crowdsourcing present alternative methods delivering support however limited work done area caregivers objective primary aims study determine feasibility innovating peer support group work delivered social media friendsourcing whether intervention provides acceptable method caregivers obtain support whether caregiver outcomes affected intervention facebook app provided support caregivers collecting friendsourced answers caregiver questions participants social networks study secondary aim descriptively compare friendsourced answers versus crowdsourced answers methods recruited caregivers online participate week long asynchronous online closed group facebook caregivers received support moderator prompts group member interactions friendsourced answers caregiver questions surveyed interviewed participants online group assess needs views technology experience intervention caregiver questions pushed automatically participants facebook news feed allowing participants facebook friends see post answers caregiver questions friendsourced answers caregiver questions pushed crowdsource workers amazon mechanical turk platform descriptively compared characteristics crowdsourced answers friendsourced answers results total caregivers completed initial online survey semistructured telephone interview caregivers agreed participate online facebook closed group activity portion study friendsourcing crowdsourcing answers caregiver questions similar rates acceptability rated content experts respectively rates emotional support informational support groups answers appeared trend type support emphasized caregiver question emotional informational support question friendsourced answers included shared experiences crowdsourced answers conclusions found asynchronous online closed group facebook generally acceptable means deliver support caregivers people pilot small make judgments effectiveness however results trended toward improvement caregivers self efficacy sense support perceived stress results statistically significant friendsourced crowdsourced answers may acceptable way provide informational emotional support caregivers people
remains tremendous interest perovskite solar cells pscs solar energy field certified power conversion efficiency pce exceeds along research focused enhancing pce studies also underway concerning psc commercialization crucial simplify fabrication process reduce production cost facilitate commercialization herein successfully fabricated highly efficient hole blocking layer hbl free pscs vigorously interrupting penetration hole transport material htm fluorine doped tin oxide large grain based chnhpbi mapbi film thereby obtaining pce results advance commercialization pscs via simple fabrication system low cost approach respect mass production recyclability
anorexia nervosa continues remain poorly understood within eating disorders recent research theory moved away understanding aetiological causes addressing instead potential maintaining factors study focused interpersonal maintenance factors response close others relatives typically carry main burden care research found high levels carer distress unmet needs recent theories proposed emotional impact contribute expressed emotion unhelpful caregiver interactions inadvertently maintain one understudied response accommodation described process whereby caregivers assist participate symptomatic behaviours cared individual dearth research relating accommodation within eating disorders particularly qualitative accounts study utilized grounded theory methodology explore caregivers responses managing focusing particularly carers experience accommodation eight participants experience caring individual diagnosed interviewed participants recruited national eating disorder charity regional eating disorder service number themes emerged including importance caregivers emotional resources mediating accommodation responses low perceived efficacy contributed caregiver burnout decreased emotional resources influenced shift caregiving aims conducive accommodation nevertheless carers perceived accommodation counterproductive recovery consequently experienced internal conflict cognitive dissonance dissonance reduced using number cognitive behavioural strategies implications findings discussed reference existing literature copyright john wiley sons ltd
lack inhibitor function results excessive production bradykinin causing angioedema seen hereditary angioedema hae well established several drugs developed treat prevent attacks patients suffering hae due inhibitor deficiency inh hae plasma derived cinh used replace deficiency inhibitor cinh approved treatment attacks prophylactic therapy prevent attacks plasma kallikrein inhibitor ecallantide bradykinin receptor antagonist icatibant effective treatment acute attacks short half life limits use prophylaxis androgens particular danazol effective long term prophylaxis adverse event profile limit use recombinant inhibitor derived transgenic rabbits recently approved use treatment inh hae attacks effective appears safe minimal adverse event profile
creating environment enable seamless integration experiment computation data within laboratory environment essential enabling practice integrated computational materials engineering environment depends connection experimental equipment high performance computing resources collaborative software environment supports research teams simulation tool sharing archival data management secure manner key functions system include project management workflow management tool staging data provenance tracking user authentication overview provided efforts establish integrated collaborative environment research laboratory involved material process discovery development structural functional materials
achieving security distributed systems constrained devices like wireless sensor networks requires methods performed limited computational memory communication resources available moreover designing security protocols one needs take account adversary eavesdrop communication compromise devices achieve level security two communicating devices need establish communication key setting severely constrained devices traditional methods infeasible due resource limitations one incorporate security providing methods one first protocols introduced eschenauer gligor paper followed dozens others relies probabilistic key sharing among nodes deployment key predistribution hoc environment paper show regular protocols key predistribution designed primarily providing confidentiality communication provide privacy many natural scenarios precisely even weak adversary may link transmissions nodes particular even passive adversary eavesdropping communication easily recognize whether devices start communication several times information breaches nodes privacy also starting point advanced attacks give significant information network activity define several models adversary introduce general methods used addressing issue model weaker adversary show fully secure privacy efficient manner case stronger adversary propose method based local key exchange allowing mitigation privacy threat elsevier rights reserved
project mev pet cyclotron accelerator medical diagnosis treatment started amirkabir university technology low level system cyclotron accelerator designed stabilize acceleration voltage control resonance frequency cavity work intelligent low level radio frequency circuit illrf suitable avf cyclotron accelerators designed using beam monitoring device narrow band tunable band pass filter design phase detection need signal processing microcontroller
problem india struggles gender inequality issues beyond equal economic growth access educational resource opportunities gender inequality exists form socially constructed predefined gender roles firmly anchored india sociocultural fabric deep cultural historical roots sociocultural influences spillover effects across domains including organizational workforce social political contexts unquestionable influence still accepted norm within societal familial periphery solution purpose article provide analysis causes gender inequality india secondary purpose outline possible policies practices within human resource development hrd framework could implemented productive steps toward reducing gender inequality indian workplace stakeholders article interest individuals conduct research teach practice hrd assist researchers understanding social cultural historical contexts must considered studying gender inequality india information gained article help curriculum developers understand importance social cultural influences developing hrd courses use higher education institutions also workplace settings
osteoporosis low bone strength sarcopenia low muscle mass strength impaired function often exist hence term sarco osteoporosis similar health consequences regard disability falls frailty fractures exercise adequate nutrition particularly regard vitamin calcium protein key lifestyle approaches simultaneously optimize bone muscle functional outcomes older people individually tailored appropriately prescribed terms type dose forms exercise equally effective optimizing musculoskeletal health regular walking alone little effect bone muscle traditional progressive resistance training prt effective improving muscle mass size strength mixed effects muscle function falls may due common prescription slow controlled movement patterns present targeted multi modal programs incorporating traditional high velocity prt weight bearing impact exercises challenging balance mobility activities appear effective optimizing musculoskeletal health function reducing breaking sitting time may also help attenuate muscle loss also evidence support interaction exercise various nutritional factors particularly protein multi nutrient supplements muscle bone health elderly review summary provides overview latest evidence regard optimal type dose exercise role various nutritional factors preventing bone muscle loss improving functional capacity older people
paper dna algorithms proposed perform eight operations relational algebra calculus include cartesian product union set difference selection projection intersection join division biomolecular relational databases
evaluated feasibility efficacy community approach learning mindfully calm program educators calm brief daily school based intervention promote educator social emotional competencies stress management wellbeing two middle schools randomly assigned waitlist control condition calm program participants included educators intervention sessions included gentle yoga mindfulness practices offered days per week weeks pre posttest measurements included self report surveys social emotional functioning wellbeing blood pressure readings diurnal assays cortisol compared control condition calm significant benefits educators mindfulness positive affect classroom management distress tolerance physical symptoms blood pressure cortisol awakening response trend level effects two measures related stress burnout impacts observed relational trust perceived stress sleep effect sizes significant impacts ranged educators found intervention feasible beneficial method managing stress promoting wellbeing initial evidence suggests calm potential strategy improve educators social emotional competence wellbeing prevent stress related problems support classroom functioning
one significant challenges involved efforts understand effects repeated earthquake cycle activity computational costs large scale viscoelastic earthquake cycle models computationally intensive viscoelastic codes must evaluated thousands times locations result studies tend adopt fixed rheological structures model geometries examine predicted time dependent deformation short years time periods given depth large earthquake training deep neural network learn computationally efficient representation viscoelastic solutions time location large range rheological structures allows calculations done quickly reliably high spatial temporal resolutions demonstrate machine learning approach accelerates viscoelastic calculations magnitude acceleration enable modeling geometrically complex faults thousands earthquake cycles across wider ranges model parameters larger spatial temporal scales previously possible
dlv powerful system knowledge representation reasoning supports answer set programming asp logicbased programming paradigm solving problems fully declarative way dlv widely used academy importantly fruitfully employed many relevant industrial applications main stream asp systems first phase computation dlv eliminates variables generating ground program semantically equivalent original one significantly smaller herbrand instantiation general phase called grounding plays key role successful deployment real world contexts work present dlv brand new version intelligent grounder dlv relying solid theoretical foundations predecessor completely redesigned engineered algorithms data structures features full support asp core standard language increased flexibility customizability significantly improved performances extensible design eases incorporation language updates optimization techniques dlv results stable efficient asp instantiator turns full fledged deductive database system describe main features dlv carry experimental activities assessing applicability performances
late life depression lld common emotional mental disability elderly population characterized presence depressed mood loss interest pleasure daily activities depression symptoms serious effect quality life elderly individuals increases risk developing physical mental diseases important area research given growing elderly population brain functional connectivity modifications represent one neurobiological biomarker lld even date remains poorly understood study enrolled elderly patients depressive symptoms compared age matched healthy controls participants evaluated means neuropsychological tests underwent functional magnetic resonance imaging fmri protocol evaluate modifications brain resting state functional connectivity group differences observed geriatric depression scale hamilton depression rating scale higher scores patients lld voxel wise way analysis variance revealed group differences left frontoparietal network lfpn sensory motor network smn increased intrinsic connectivity lld group observed left dorsolateral prefrontal cortex left superior parietal lobule lfpn increased intrinsic connectivity lld group observed bilateral primary somatosensory cortex smn findings support use resting state fmri potential biomarker lld even confirm relationship brain changes pathophysiology lld longitudinal neuroimaging studies required
visual cryptography scheme vcs cryptographic technique hide image based secrets even though vcs major advantage decoding done help human visual system hvs yet provide sufficient reconstruction quality hence two one image secret sharing scheme tioisss used provides two decoding phases however existing tioisss method several limitations work modified tioisss proposed adaptive threshold used halftoning changes depending nature pixels present image quality reconstructed secret image improved first decoding stage compared existing scheme addition security also enhanced pixel bit level permutation bit key embedding key gray vcs shadows verify authenticity image secret message also embedded shadows security analysis shows modified tioisss robust brute force man middle attacks
low hydroxy vitamin serum concentrations associated higher disease activity multiple sclerosis patients large cross sectional study assessed vitamin status patients relation seasonality relapse rate patients relapsing remitting secondary progressive female mean age years serum concentrations determined visits included study clinical data including relapse visit expanded disability status scale recorded standardized manner experienced neurologist seasonal variations serum concentrations modelled sinusoidal regression seasonal variability prevalence relapse cubic regression mean serum concentration range peak levels july august nadir january february lowest modelled prevalence relapse september october highest modelled prevalence march april nadir serum concentrations preceded peak prevalence relapses two months summary seasonal variation serum levels inversely associated clinical disease activity patients future studies investigate whether vitamin supplementation patients may decrease seasonal risk relapses elsevier rights reserved
years ago electromagnetic valve trains topic many research projects automotive industry despite promising approaches technology chance prevail market yet meantime reinforced market restrictions introduced improved technical boundary conditions available task project reevaluate electromagnetic valve train emvt technology new circumstances dynamic simulation environment dymola modelica created able simulate multidisciplinary system includes magnetic electrical mechanical controller subsystem biggest challenge regarding controller development high dynamic valve movement considered implementing repetitive learning feed forward controller developed matalb simulink targetlink via fmi interface simulation simulation shows concept based conventional spring mass system additional lateral magnets able open valves internal combustion engine simultaneously sufficient impact velocity control
background aim investigate whether mean perfusion pressure mpp calculated difference mean arterial pressure map central venous pressure cvp associated risk progression aki aki iii critically ill patients methods retrospective analysis adult patients admitted multi disciplinary adult intensive care unit icu july june developed aki advanced haemodynamic monitoring initiated within diagnosis aki compared patients mpp median value first diagnosis aki multivariable logistic regression analyses performed identify independent risk factors progression aki iii explore impact map cvp separately investigate impact mpp pre defined sub groups results among icu patients patients developed aki underwent advanced haemodynamic monitoring within aki stage median mpp mmhg aki patients mpp mmhg significantly higher risk progressing aki stage iii versus respectively association stronger patients ischemic heart disease congestive cardiac failure without pre existing hypertension patients map individual components raised cvp independently associated progression aki stage iii map alone independent risk factor aki progression conclusion mpp mmhg independently associated aki progression cvp key component mpp
integration smart patches full tension splice connectors overhead power transmission lines investigated lead zirconate titanate pzt used smart material aluminum beam used host structure negative electrode termination examined using copper adhesive tape direct bonding methods various commercial adhesives studied pzt integration onto host structure aluminum beam specimens integrated pzt smart patches tested thermal cycling temperature degrees higher end temperature experienced service aluminum conductor steel reinforced cables electromechanical impedance emi measurements conducted room temperature root mean square deviation rmsd conductance signals used analyze emi data shown negative electrode method important effect performance integrated pzt pzt displayed susceptibility cracking copper tape used direct bonding used reliability pzt direct bonding depended adhesives used bonding layers although hard alumina based adhesive lead cracking pzt high temperature epoxy adequate flexibility duralco provide desired performance target thermal cycling conditions rmsd parameter characterize conductance signatures effectively also demonstrated rmsd used quantify fatigue pzt integration system although rmsd used primarily damage index monitoring structural health
background role tumor molecular profiling directing targeted therapy utilization remains defined pediatric tumors aimed evaluate feasibility sequencing molecular biology tumor board mbb program clinical impact children solid tumors procedure report single center mbb experience pediatric patients poor prognosis relapsed refractory solid tumors screened october november tumor molecular profiling performed panel based next generation sequencing array comparative genomic hybridization results mean age years range main tumor types high grade gliomas rare sarcomas neuroblastomas indication poor prognosis tumor diagnosis patients relapsed refractory disease remaining patients molecular profiling feasible patients twenty three patients potentially actionable finding patients high grade gliomas highest number targetable alterations six patients subsequently received matched targeted therapy period ranging days months main reasons receiving targeted therapy poor general condition pursuit conventional therapy lack pediatric trial conclusions pediatric molecular profiling feasible third patients eligible receive targeted therapy yet small proportion treated therapies analysis diagnosis may useful children poor prognosis tumsors
current study replicated extended previous research disordered eating dietary intent self reported restriction caloric intake purpose losing weight boys men examining direct indirect influence sociocultural pressure social body comparisons internalization societal appearance ideals body dissatisfaction self esteem body composition cardiorespiratory fitness crf dietary restraint participants boys bar age years six middle schools located south central united states using structural equation modeling sem dietary restraint variance explained across two independent samples pressures lose weight diet predicted psychosocial outcomes whereas higher levels crf predicted higher levels body satisfaction self esteem lower body mass indices bmis predicted lower dietary restraint results study support multifactorial approach understanding boys dietary behaviors
diesel engines produce high emissions smoke particulate matter nitrogen oxide challenge decrease exhaust emissions without making major changes mechanical configuration therefore adding hydrogen becomes natural choice enhance performance emissions diesel engines paper offers overview effect hydrogen additional diesel engine overall finding review suggests air fuel ratio engine speed engine load play key role performance emission diesel engines hydrogen enrichment brake thermal efficiency bte brake power output brake means effective pressure bmep specific energy consumption sec dependent operating conditions engine adding hydrogen also found increasing percentage hydrogen affect emissions reduction unburned hydrocarbon carbon monoxide carbon dioxide particulate matter smoke observed adding hydrogen however nitrogen oxide increased enriching increase controlled numerous injections exhaust gas recirculation egr water injection well exhaust treatment discussed paper elsevier ltd rights reserved
research parkinson disease drug development hampered lack suitable human vitro models simply accurately recreate disease conditions counteract many attempts differentiate cell lines human syy neuroblastoma dopaminergic neurons undertaken since easier cultivate compared cellular models characterized neuronal features discriminating undifferentiated retinoic acid differentiated sysy cells described significant differences cell models hydroxydopamine ohda cytotoxicity contrast undifferentiated cells differentiated syy cells demonstrated low proliferative rate pronounced neuronal morphology high expression genes related synapse vesicle cycle dopamine synthesis degradation dopamine transporter dat significant differences undifferentiated differentiated syy cells overall capacity antioxidant defenses found although differentiated syy cells presented higher basal antioxidant capacity high resistance insult twofold sensitive ohda dat inhibition alpha bis fluorophenyl methoxytropane dithiothreitol cell permeable thiol reducing agent protected differentiated undifferentiated syy cells oxidative damage cell death caused ohda demonstrate undifferentiated differentiated syy cells two unique phenotypes also dissimilar mechanisms ohda cytotoxicity hence data support use differentiated syy cells vitro model study may impact understanding pathological mechanisms development new therapies drugs management disease
closed loop frequency tracking electronics circuit proposed measurement pressure temperature using newly developed langasite lgs piezo crystals ambient force heat applied lgs crystal produces shift resonant frequency proposed closed loop electronics tracks shift resonant frequency measures pressure temperature relating difference frequency shift steady state oscillation condition resonator circuit analytically derived experimentally verified experimental setup consists operational amplifier based resonator circuit connected langasite piezo crystal placed double side diametric forces loading device temperature controller bath diametric force applied lgs crystal produces frequency shift fundamental mechanical vibration mode cmode similarly change temperature produces frequency shift second mechanical vibrational mode bmode frequency shifts measured using two separate closed loop resonator electronics two different measurand whenever force lgs crystal changed external unknown pressure additional intrinsic material property change added piezo changes fundamental oscillating resonant frequency closed loop resonant circuit tracks change resonance frequency vibrates lgs new resonance frequency depends external pressure strength similar procedure followed temperature induce frequency tracking measurement also proposed frequency tracking electronics concept simple found high sensitivity linearity
work describes innovative educational project related three subjects degree materials engineering involves coordination among lecturers subjects production new educational material implies active participation students favour autonomous learning development generic specific skills associated subjects methodology consists learning based real industrial problems divided two parts analyzed solved diverse points view subject physical problems solved subjects electronic thermal behavior materials optical magnetic behavior materials second part treated subject ceramic materials example real industrial application optical fiber associated problems materials specific optical properties another important aspect selection ceramic material choice design manufacturing process etc new procedures evaluation acquired knowledge developed skills established evaluate success activities opinion students taken account voluntary anonymous surveys
ultrawideband photonic phase shifter implemented using two cascaded polarization modulators polms proposed experimentally demonstrated first polm polm employed generate optical carrier two first order sidebands orthogonally polarized aligning polarization directions optical carrier two first order sidebands first polm two principal axes second polm polm complementary phase modulation optical carrier first order sidebands produced voltage applied second polm selecting optical carrier one sideband using optical filter beating photodetector signal phase tunable tuning applied voltage generated proposed phase shifter advantages fast tuning ultrawide frequency tunable range experiment performed full degrees phase shift ultrawide frequency range ghz demonstrated spurious free dynamic range phase shifter also studied
describe technique shape modification applied thin walled similar thickness electroformed replicated optics glass optics improve near net shape mirror well mid frequency similar length scales ripple process involves sputter deposition magnetic smart material msm film onto magnetically hard material one retains magnetic field material hard disk drives since previous report made extensive measurements deflection versus magnetic field strength direction report results along detailed finite element analysis modeling
background inflammatory bowel disease ibd occurs frequently patients psoriasis diseases significant genetic overlap pathogenesis underlying occurrence unknown objective sought report adjudicated ibd cases crohn disease ulcerative colitis patients exposed ixekizumab high affinity monoclonal antibody selectively targets interleukin methods adverse events aes integrated randomized controlled uncontrolled trials analyzed controlled induction period controlled maintenance period ixekizumab treated patients suspected ibd cases reviewed blinded external experts using internationally recognized criteria registre epidemiologique des maladies appareil digestif registry results patients patient exposure years exposed ixekizumab suspected aes reported adjudicated definite probable ibd incidence rate patient exposure years incidence rate patient exposure years among occurred induction maintenance twelve patients reported ibd history ibd treatment emergent serious date limitations clinical review adjudication prespecified data collected post hoc may limited length time occurrence conclusion integrated database ixekizumab psoriasis trials cases uncommon
body appreciation found linked interpersonal intrapersonal factors attachment styles self compassion separately identified important correlates present study examined variables together model hypothesized maternal attachment anxiety related peer romantic attachment anxiety turn associated self compassion body appreciation using structural equation modeling cross sectional study sample incoming first year college women found proposed model explained variance body appreciation results revealed peer romantic attachment anxiety mediated relationships maternal attachment anxiety self compassion self compassion mediated associations peer romantic attachment anxiety body appreciation self compassion appears hold central role explaining relation attachment anxiety body appreciation elsevier ltd rights reserved
integrity verification chip flash memory data code memory becoming important microcontroller based applications automotive systems fly memory fail detection requires fast detection method seamless background mode without interruption cpu operation low power flash access hardware provide safety conscious execution user programmed firmware system operations paper newly designed read path architecture based binary inversion techniques proposed chip flash embedded microcontrollers proposed binary inversion method also enables fail safe low power memory access zero hardware overhead embedding scramble flags cyclic redundancy check crc protection code time multiplexed crc calculation bit inversion binary code automatically executed silent background mode cpu idle time without cpu wait cost implementation result shows inversion procedure could achieved additional bits crc data case sectors flash memory reducing area previous work code memory integrity verification time seamless background mode conventional foreground method total average current code execution dhrys tone benchmark uses basement
aim determine incidence main characteristics cerebrovascular events presenting manifestations myeloproliferative neoplasm mpn methods hematology lyon hemily registry prospective database patients cases mpn diagnosed since rhone alpes district france mpn cases divided four groups polycythemia vera essential thrombocythemia myelofibrosis atypical mpn ischemic stroke subtype classified according toast criteria results stroke history revealed mpn patients ischemic stroke eight transient ischemic attack four cerebral venous thrombosis one hemorrhagic stroke patients hemoglobin platelet count abnormalities addition patients one one atypical unclassified mpn jak mutation found patients patients additional mechanism stroke present atherosclerosis patients atrial fibrillation one patient dissection another median nihss score entry median modified rankin scale score months compared general mpn population stroke mpn patients presented significantly higher levels hemoglobin frequently positive jak mutation conclusion stroke revealing mpn rare however careful attention still paid blood counts even patients obvious stroke etiologies early diagnosis permits prompt treatment decreases risk recurrence thus limiting morbidity mortality elsevier masson sas rights reserved
development control system tokamak demonstration fusion reactor demo faces unprecedented challenges first requirements control reliability accuracy stringent existing fusion devices loss plasma control demo may result disruption could damage inner wall machine operating device larger margins operational limits would lead reduction electrical output power second performance demo control limited space restrictions implementation components optimization tritium breeding rate lifetime issues front end parts neutron gamma radiation erosion deposition acting components slow weak indirect action available actuators plasma shaping heating fuelling european demo conceptual design studies include development reliable control system since details achievable plasma scenario machine design may depend actual performance control system first phase development initial understanding prime choices diagnostic methods applicable demo implementation performance issues interrelation plasma scenario definition planning necessary future obtained published elsevier
football currently popular sporting activity world multiple reports shown high incidence osteoarthritis found football players evidence clearly shows traumatic injury significantly predisposes players pathophysiology injuries frequent amateur well professional football players knee ankle accounting severe injuries many professional athletes lose playing time due injuries many forced early retirement posttraumatic osteoarthritis common finding among football players numbers well normal population today surgical techniques advanced capable restoring joint certain extent however restitution integrum reached rare cases professional football players return play serious injuries perform extremely strenuous activity morphologically compromised joints incomplete rehabilitation pressure return play injurious event clearly put athlete even higher risk joint degeneration prevention strategies improved surgical management strict rehabilitation well future aspects early suppression inflammation personalized medicine predictive genomics dna profiling needed reduce incidence improve health perspectives football players
background cognitive deficits well documented patients bipolar disorder bpd may impact efficacy psychotherapy cognitive control form executive functioning often used therapeutically shift patients thoughts behaviors automatic maladaptive responses adaptive coping strategies study examined cognitive control processing patients bpd using multi source interference task msit method twenty nine patients diagnosed bpd healthy control subjects completed msit concurrent functional magnetic resonance imaging fmri results patients bpd generally performed worse msit relative participants bpd group significantly lower performance accuracy made omission errors fmri analyses revealed differential patterns activation groups msit region interest roi analyses revealed relative participants patients bpd activated significantly fewer voxels within cingulate cortex voxels within prefrontal cortex pfc although pfc findings survive stringent significance thresholds limitations patients hcs matched age sex premorbid verbal however variables controlled statistically medication usage bpd group may possibly impacted results given priori hypotheses roi analyses utilized conclusions decreased activation increased pfc activation may associated impaired cognitive control demonstrated bpd patients completing msit identifying neural mechanisms underlie key cognitive abnormalities bpd may aid clarifying pathophysiology disorder inform selection potential targets cognition remediation bpd
modern energy demands led scientific community renewable energy sources ocean wave energy present work describes model cost efficient rotary electrical generator optimized ocean wave energy conversion electrical power supplied low speed mechanical movement requires use electrical machinery capable generating high amounts torque among analyzed topologies one selected study transverse flux permanent magnet machine tfpm topology differs conventional ones presenting high power torque densities allowing independently set machine current magnetic loadings machine machine designed analyzed use fem software obtained results show tfpm strong candidate used large scale converting systems
need clarify phase transition nucleation propagation phenomena polycrystalline niti shape memory alloy extremely small scale compressive loading present study strain stress indentation curves temperature rise phase transition volume plastic volume hardness smart material static dynamic loading discussed hypothesis proposed nucleation propagation phase transition volume underneath stressed spot according indentation curve jagged loading unloading stages evidences discrete nucleation propagation phase transformed zone elsevier ltd rights reserved
past years many choreographers focused upon implementation computer technology enhance artistic skills computer vision technology presents new methods learning instructing developing assessing physical movements well provides scope expand dance resources rediscover learning process work reviews study done based learning technologies development inter personal skills paper elaborates literature done till date within scope based training educational aspects review focuses techniques categorized according type dance learning method enhanced addressed means novel based technology authors aim provide overview learning standards based kinect sensors addition future work toward exploring latest version kinect dance training could become next futuristic virtual educator
accurate behavioral measurement essential developing science leadership yet accurate measurement remained elusive use follower reports leader behavior creates challenges given large body basic applied research suggests behavioral ratings reflect recall actual behaviors also inferences based semantic memory may vary among individuals paper examine several explanations rater effects associated follower individual differences contextual factors even research methods type measure used may bias ratings leader behavior also develop conceptual model illustrate processes finally offer potential solutions increase accuracy follower reports leader behavior elsevier inc rights reserved
problem estimation signal composed multiple harmonic signals decomposition parameters frequencies amplitudes phases dealt existing approaches estimation signals unknown frequencies reviewed presented approach extension estimation algorithm one harmonic signal constant unknown frequency approach based fact single harmonic signal represented rotating two dimensional vector thus equations motion rotating vector exploited application state space representation enabled generalization signal multiple harmonic presented estimator state dependent differential riccati equation sddre based estimator simulations demonstrate vitality approach
use vegetables oils compression ignited internal combustion engine presents critical issues large amount carbon deposits tip injectors significantly influence emissions engine performance previous draft methodology developed authors based images capture post processing carbon deposit correlated number pixels gray scale possible determine fouling index first results showed interesting perspectives limits aim present work optimization test bench methodology first improvement image acquisition increasing sampling frequency image resolution performed replacing old camera digital microscope improving injector microscope positioning test bench prototype realized aid printing obtaining hindamental mechanical components also alternative methodology proposed evaluate carbon deposits volume volumetric index new methodology validation done using images sampled previous test bench performances fouling index new volumetric index compared fouling examined real case diesel engine fed diesel sunflower oil results show greater reliability new volumetric index authors published elsevier ltd
neurodegenerative diseases considered distinct clinical entities although share formation proteinaceous aggregates several neuropathological mechanisms increasing evidence suggest possible interaction proteins classically associated distinct neurodegenerative diseases thus common molecular cellular pathways might explain similarities disease phenotypes interestingly characteristic parkinson disease phenotype linked bradykinesia also clinical presentation neurodegenerative diseases example machado joseph disease mjd patients presenting parkinsonism positive response levodopa dopa protein aggregates positive alpha synuclein alpha syn protein associated substantia nigra mjd models made hypothesize putative additive biological effect induced expression alpha syn ataxin atx protein affected mjd hence study analysed influence two proteins alpha syn wild type mutant atx modified redox signaling pathological process potentially linked diseases also impact exposure iron rotenone syy neuroblastoma cells results show alpha syn mutant atx overexpression per increased oxidation dichlorodihydrofluorescein dcfh expression proteins exhibited additive effect intracellular oxidation correlation apoptotic features mutant atx alpha syn also potentiated altered redox status induced iron rotenone hint proteins might influence neuronal dysfunction pro oxidant conditions show overexpression wild type atx decreased intracellular dcfh oxidation possibly exerting neuroprotective role
genomics disruptive technology revealed cancers tremendously complex differ patient patient therefore conventional treatment approaches fit poorly genomic reality furthermore likely type complexity also observed illnesses precision medicine posited way better target disease related aberrations developing drugs tailoring therapy patient complicated problem major challenge one solution would match patients existing compounds based silico modeling however optimization complex therapy eventually require designing compounds patients using computer modeling time production perhaps achievable future three dimensional printing indeed printing potentially transformative virtue ability rapidly generate almost limitless numbers objects previously required manufacturing facilities companies already endeavoring develop affordable printers home use attractive yet scantily explored application place chemical design production digital control could accomplished utilizing printer initiate chemical reactions print reagents final compounds directly interest food drug administration fda recently approved printed drug levetiracetam indicated seizures increasingly clear biologic materials tissues eventually organs also printed near future plausible high throughput computing may deployed design customized drugs reshape medicine
proposed frequency locked loop fll utilizes flat frequency response characteristics moving window filter mwf closed loop adaptive sampling pulse adjustment capacitance measurement operational amplifier amp based relaxation oscillator generates square wave whose fundamental sine wave extracted mwf fundamental sine wave tracked fll estimate frequency inversely proportional unknown capacitance fll employs another mwf track center frequency variation due capacitance mwf offers almost flat frequency response around center frequency closed loop however small magnitude phase errors observed flat frequency response corrected adjusting sampling pulses adaptively experimental investigation demonstrates capabilities scheme wider accurate capacitance measurement
objective determine whether lymphocyte depletion act promote immunological tolerance induction way intravenous antigen administration could used either improve efficiency multiple sclerosis inhibition inhibit secondary autoimmunities may occur following alemtuzumab use relapsing experimental autoimmune encephalomyelitis induced abh mice immune cell depletion therapeutically applied using mouse conjunction depleting monoclonal antibodies immunological unresponsiveness subsequently induced using intravenous central nervous system antigens responses assessed clinically dose response monoclonal antibody depletion indicated functional cell depletion achieved perceived failed trials perhaps low even stop disease animals however marked similar physical depletion cells depleting antibodies inhibited relapsing disease surprisingly contrast depletion depletion blocked robust immunological unresponsiveness mechanism involving cells although efficacy related level cell depletion observations depletion cells less marked lymphoid organs blood provides rationale rapid cell hyper repopulation occurs following alemtuzumab administration cells repopulate relative absence cell regulatory mechanisms promote immune tolerance may account secondary cell autoimmunities occur following alemtuzumab treatment
objective study compare moderate vigorous physical activity mvpa minutes per week min fulfillment current recommendation min mvpa based different cut points postmenopausal women sample composed postmenopausal women aged years old mvpa measured using triaxial accelerometers accelerometers initialized collect epochs participants included using least days mvpa min obtained using freedson troiano copeland sasaki cut points box plot indicated large mean differences almost cut points except freedson troiano loa min proportion women achieved min mvpa similar freedson troiano sasaki copeland cut points resulted greater proportion cut points concluded cut points analyzed generated different results mvpa min low agreement using current guidelines mvpa pattern classification except comparisons freedson troiano cut points
frequency selective surface monolayer multilayer periodic structure composed multiple resonance units scattering two dimensional periodic array dielectric layer fss absorb radio frequency energy filter frequency therefore applied microwave technique stealth technology relative research curved fss relatively scarce since curved fss structure obtained fss attached materials surfaces curved structures engineering application however curved fss widely applied practical engineering therefore research curved fss structure important significance paper curved fss structure model pore unit established numerical simulated means fdtd influence curvature fss transmission characteristics studied according analysis changing radar cross section rcs results show center frequency point plane band pass fss structure drifts curve surface deformation structure center frequency point curved band pass fss structure drifts changing curvature radius decreasing curvature radius frequency point drifts towards high points transmittance decreases design fss radome demands accurate stable center resonance frequency therefore actual situation curved surface considered practical engineering application band pass fss made frequency selection filtering radome curvature radius long enough avoid center frequency drifting transmittance deceasing
single component nonrelativistic dissipative fluids treated independently reference frames flow frames first basic fields balances derived related thermodynamic relations entropy production calculated linear constitutive relations given usual basic fields mass momentum energy current densities heat flux pressure tensor diffusion flux time spacelike components third order mass momentum energy density flux four tensor corresponding galilean transformation rules physical quantities derived proved non equilibrium thermodynamic frame theory including thermostatic gibbs relation extensivity condition also entropy production independent reference frame also flow frame fluid continuity fourier navier stokes equations obtained almost traditional form flow fluid fixed temperature choice flow frame thermo flow simple consequence theory relation total kinetic internal energies galilean transformation rule
neuropsychiatric research including related circadian system performed using nocturnal animals mainly laboratory mice rats mood disorders known associated circadian rhythm abnormalities mechanisms circadian rhythm disruptions interact depression remain unclear circadian system diurnal nocturnal mammals differs previously suggested utilization diurnal animal models may advantageous understanding relations last years others established validity several diurnal rodent species model interactions circadian rhythms depression diurnal rodents respond photoperiod manipulation similar way humans behavioral outcome directly related circadian system treatment effective patients also effective model moreover less effective treatments patients also less effective model therefore suggest using diurnal animal models study circadian rhythms related affective disorders depression provide new insights hopefully lead development effective treatments drug dev res wiley periodicals inc
although links childhood residential mobility subsequently increased risks psychopathology well documented associations across full spectrum psychiatric disorders unknown conducted population based study persons born denmark investigate relationships childhood cross municipality residential moves year birth age years development range psychiatric disorders mid adolescence early middle age examined substance misuse disorders specifically alcohol misuse cannabis misuse personality disorders specifically antisocial borderline personality disorders schizophrenia related disorders specifically schizophrenia schizoaffective disorder mood disorders specifically bipolar disorder depressive disorder anxiety somatoform disorders specifically obsessive compulsive disorder eating disorders specifically anorexia nervosa childhood residential mobility associated elevated risks developing psychiatric disorders even controlling potential confounders associations generally rose increasing age moving stronger multiple moves year compared single move links particularly strong antisocial personality disorder substance misuse disorder cannabis misuse particular highest increases risks observed relocation occurred adolescence childhood residential change linked subsequent risk developing eating disorder frequent residential mobility could marker familial adversities mental health services schools need vigilant psychosocial needs children particularly adolescents recently moved homes authors published elsevier ltd
due direct impact safety function organizations occupational health concern construction industry many years inherent complexity occupational health management presents challenges make systems approach essential systems perspective health conceptualized emergent property system processes operating individual organizational level inextricably connected based fundamental behavior performance outcome theory industrial organizational psychology study presents development input coping behaviors health performance outcomes health management systems model spanning individual organizational boundaries model based survey hong kong expatriate construction professionals working mainland china professionals tend considerable stress due adverse work environment dynamic tasks also need confront cross cultural issues arising expatriation questionnaire designed based focus groups involving participants followed pilot study questionnaires distributed main study valid returns received giving response rate data analyzed using statistical techniques factor analysis reliability testing pearson correlation analysis multiple regression modeling structural equation modeling theories coping behaviors health performance tend focus isolated causal effects single factors posits model single individual level industrial practices health management tend focus organizational policy training developing health management system incorporating individual interpersonal organizational perspectives study bridges gap theory practice providing empirical support systems view health management elsevier ltd rights reserved
impairments renin angiotensin aldosterone system diabetes mellitus leading dysfunction known since decade hyperglycemia induces several pathological alterations upregulate system accounting overexpression downstream signaling molecules amongst angiotensin ang aldosterone hold prime pathological notoriety although well known elevated plasma levels ang play crucial role pathophysiology type diabetic mellitus inducing aggravating insulin resistance quite much known equally elevates possibility risk development diabetic complications also amongst various diabetic complications effects ang upregulation widely acknowledged studies concerning pathophysiology diabetic nephropathy however role exacerbating diabetic retinopathy received much attention ang indeed plays detrimental role progression diabetic retinopathy augmenting principal events involved pathogenesis namely oxidative stress angiogenesis inflammation utility angiotensin receptor blockers shown positive results research studies hence might potentially provide novel adjuvant therapy treating complication preventing associated vision loss diabetic patients elsevier inc rights reserved
home automation one customers electrical energy industry lighting represents average annual electricity bill excluding gas hot water different studies made reduce electrical energy consumption like automatic switching time programming techniques important rate reducing electrical energy consumption note intelligent lighting varies users need remains important source economy energy intelligent lighting obtained using ambient intelligence ami multi agent system mas become important paradigm develop ambient system important characteristics like autonomy proactivity mobility respond better main characteristic ambient intelligence like adaptability context area propose adaptive intelligent lighting system light source represented software agent set agents compose coordinate competences order illuminate region minimum energy consumption
two licenses mhz band digital satellite vehicle radio broadcasting united states potential advantages system motorist enjoy commercial free music digital quality sound seamless coast coast coverage one proposal broadcast system two satellites covering continental usa given time also terrestrial repeaters cities receivers vehicles see two satellites channels systems affected rician rayleigh flat fading caused shadowing paper proposes forward error correction fec scheme robust fading also enables low delay tuning channel minimum tuning delay occur user switching selecting programs scheme uses multiple source coded bit streams employing different interleaver depths large interleavers used ensure good decoded signal quality small interleavers used minimize tuning delay proposed scheme also ensures program interrupted momentary shadowing frequently experienced motorist example vehicle goes highway overpass impact interleaver design real time end end delay fading due shadowing analyzed finally channel code performance rician rayleigh fading channels also presented
recent years ugandan government proposed number laws attempt control sexual conduct ugandan population much debated anti homosexuality bill signed museveni february overturned constitutional grounds august well known examples include legal measures related hiv aids defilement prostitution pornography article analyzes contexts laws recent public debates sexuality emerged consequences entail argue must seen relation ongoing power struggles local national level men women youth elders state citizens based discourse analysis drawing ethnographic fieldwork show state non state actors exploit popular concerns recent processes social change instrumentalize sexuality extend control reinforce normative order based patriarchal values
priority wise channelization resources key successful environmental management especially funds limited study hand successfully developed algorithmic criterion compare hazardous effects municipal solid waste msw dumping sites quantitatively multi criteria analysis mca made use scaling function normalize data values analytical hierarchy process ahp assigning weights input parameters showing relevant importance weighted linear combination wlc aggregating normalized scores input parameters divided three classes namely resident concerns groundwater vulnerability surface facilities remote sensing data gis analysis used prepare input data elaborate idea four dumpsites chosen case study namely old fsd new fsd saggian mahmood booti comparison made first class levels class scores aggregated environmental normalized index environmental impact ranking hierarchy goodness found selected sites new fsd old fsd mahmood booti saggian comparative scores goodness environment respectively flexibility proposed model adjust number classes parameters one class helpful developing world availability data biggest hurdle research based environmental sustainability planning model run even without purchasing satellite data gis software little inaccuracy using imagery measurement tools provided google earth
previous research found association childhood trauma insecure attachment psychological distress risk violence engagement therapy aim study investigate relationships factors forensic population sixty four participants three secure psychiatric hospitals completed childhood trauma questionnaire ctq relationship scales questionnaire rsq clinical outcomes routine evaluation outcome measure core overall scores participants historical clinical risk management violence risk assessment scheme hcr calculated staff evaluated participants engagement therapy via completion service engagement scale ses retrospective study found childhood trauma insecure attachment significantly predicted psychological distress risk violence associations engagement found methodological reasons outcome acknowledged importance routinely assessing history childhood trauma insecure attachment highlighted
current major challenge leprosy control prevention permanent disabilities host pathological inflammatory responses termed type reaction leading cause nerve damage leprosy patients environmental inherited factors predispose leprosy cases undergo known however studies shown important contribution host genetics susceptibility previously identified variants encompassing tnfsf tnfsf genes risk factors vietnamese sample replicated association brazilian sample however failed validate brazilian patients strong association tnfsf tnfsf markers observed vietnamese patients investigated lack validation variants due age dependent effects association using four independent population samples two brazil two vietnam combined analysis across four samples observed strong association tnfsf tnfsf variants combined combined combined respectively however association pronounced leprosy cases years age compared global sample odds ratio confidence interval combined versus combined multivariable analysis indicated association independent either three variants known regulators tnfsf gene transcription level multiple tissues age dependency association suggests genetic control gene expression varies across human life span
paper energy system multi carrier energy based energy hub theory evaluated aim system cost optimization respect multi carrier optimal dispatch applying demand side management program dsm attention increasing demand energy electrical natural gas etc problem related supplying paper supplying electrical energy based hybrid distribution system concept supply load electrical energy use electrical network combined heating power chp supply load electrical energy use photovoltaic panel aim dsm peak load shaving panel certain time range using panel addition providing electrical power advantages using renewable energy decreasing greenhouse gas emissions cost
robust precise control piezoelectric stages quite challenging due existence strong hysteresis nonlinearity paper dynamics piezoelectric stage identified second order linear system preceded input hysteresis characterized prandtl ishlinskii model control strategy based uncertainty disturbance estimator ude developed mitigate effect hysteresis nonlinearity improve performance positioning control piezoelectric stage without detailed model hysteresis except slope information hysteresis asymptotes moreover stability analysis closed loop system ude based controller provided extensive experimental studies carried physik instrumente piezoelectric stage demonstrate ude based controller achieve excellent performance trajectory tracking disturbance rejection compared proportional integral derivative pid controller disturbance observer based controller
construction industry significant environmental social economic impacts society result last decades witnessed rapid growth green building sector order mitigate negative impacts associated construction related activities similar conventional building projects green building projects variety objectives may necessary compatible include upfront cost ongoing savings energy savings building users health wellbeing china reported green buildings consume less energy compared conventional buildings however due incremental cost uncommon enterprises governments china unwilling bear kind risk presented significant challenges industry practitioners also facing extra demands related sustain ability research aims investigate conflicts amongst various objectives green building developments theoretical framework established depict potential conflicts amongst various objectives green building projects across life cycle theoretical framework tested empirical data collected via semi structured interviews rough set theory employed investigate conflict degree amongst various project objectives stakeholder point view implications discussed recommended resolve conflicts elsevier ltd rights reserved
aims movement time analyzer mta objective instrument evaluate degree motor impairment well investigate dopaminergic drug effect parkinson disease patients aim study validate new ecologic neuroimaging tool quantifying mta related hemodynamic response cortical motor system means functional near infrared spectroscopy fnirs materials right handed healthy volunteers six male five female age range years studied fnirs functional magnetic resonance imaging fmri performing mta task hand results mta performance better dominant hand younger participants fnirs fmri analyses revealed mta related increase haemoglobin levels primary motor premotor cortices contralateral moving hand response progressively increased aging conclusion findings supported translation fnirs based mta behavioural tool clinical practice
background slipped capital femoral epiphysis scfe frequent disorder adolescent hip may lead avascular necrosis avn femoral head chondrolysis early osteoarthritis due post slip deformity proximal femur warrant best possible outcome affected contralateral hip early diagnosis proper treatment needed methods review literature undertaken identify today role available imaging modalities management scfe summary review outlines relevancy different imaging modalities radiography ultrasound mri bone scintigraphy treatment scfe patients standard radiography first choice imaging modality patients suspected scfe ultrasound advanced imaging modalities may aid surgical planning diagnosis complications avn treatment follow
text input important part data annotation process text used capture ideas comments text entry immersive virtual environments standard keyboards usually work various approaches proposed solutions mostly proven effective still remain certain shortcomings making investigations worthwhile motivated recent research propose speech based multimodal text entry system swifter strives simplicity maintaining good performance initial user study compared approach smartphone based text entry within cave like virtual environment results indicate swifter reaches average input rate words per minute positively received users terms user experience
increase types numbers household appliances electrical appliances standby energy consumption attracted people concern reduce energy waste household appliances method energy saving control standby household appliances presented paper presented method divides indoor electrical circuits two parts one circuit powered turned algorithm fuses detected current information pyroelectric infrared sensor information put forward assure circuit cut household appliances circuit powered standby states nobody home also software hardware design schemes given detail energy saving control devices standby appliances developed last experiments made experimental results observe developed system reliable great importance energy conservation
sexting among teen mobile phone users rise study examines adolescent mobile phone users perceptions harmful effect consensual sexting two people romantic relationship mass circulated sexting sexting posted internet results survey adolescents showed respondents believed sexting greater harm others furthermore respondents perceived sexting messages posted internet harmful mass circulated sexting turn harmful consensual sexting two people additionally found gendered effect third person perception sexting males females believed females harmed sexting perception girls boys victims sexting predicts willingness support restrictions sexting hand respondents sexted less willing support restrictions
work integrated learning wil recognised industry academia benefits including preparing students workforce allowing extra resources projects opportunity trial potential recruits industry since school aerospace mechanical manufacturing engineering developed suite wil options introduced mandatory weeks industry experience undergraduate students changes introduced increase student employability decrease skills gap success attributed employment wil coordinator implementation streamlined processes increased brand awareness flexible wil options great potential new approach able diversify relationships offering flexible options students undertake placements projects industry involved educating future generations engineers
permeability measurement method based perturbed pressure decay source sink communicating porous medium formulated nonideality gas well corrections due adsorption considered method allows infer permeability given rock fluid state accuracy method may evaluated comparison theoretical decay characteristics modal amplitudes quantitative evaluation experimental inference therefore possible based pressure decay theory apparatus built laboratory measuring permeability presented secondary output data analysis also provides porosity lowest permeability present apparatus capable characterizing additional improvements capability anticipated steady state permeameter pragmatic excellent agreement two measurements showed validating method measurements synthetic samples also show method accurate porosity data standard helium pycnometer confirm porosity obtained decay method american institute chemical engineers aiche
double lined tunnels geotextiles installed shotcrete concrete linings drain ground water circumferential boundary tunnels concrete lining placement geotextile often experiences pressures young concrete curved rough shotcrete surfaces pressures transferred waterproof membrane act normal direction curved shotcrete face geotextile flow behavior conditions represented standard geotextile permeability tests instead requires specially designed performance tests consider field conditions new device evaluate permeability geotextile pressurized curved flow channels proposed adopts flexible loading system curved rough model plate testing geotextiles used tunnel drainage systems using proposed arrangement shows effects tortuousity flow pressurized channels affects significantly geotextile permeability
commonly known enzymatic transformations considerably specific classical chemical reactions usually lead formation byproducts enzymes powerful tool field analytical chemistry main problems occurring working enzymes stem relatively high price sensitivity non physiological conditions mentioned disadvantages may overcome enzyme immobilization allows reusing biocatalyst long retains activity immobilization performed correctly enzymes stable also resistant denaturation approach combination additional benefits miniaturization heterogeneous catalysis flow mode operation contributes various applications immobilized enzyme reactors imers particular microfluidic imers present review various types imers described particular attention paid techniques preparation including immobilization strategies technical solutions connected applications using capillary chip format elsevier rights reserved
electricity power basic industrial component plays important role economy nation paper correlations evolution electricity prices among states district columbia studied based random matrix theory rmt four regime shifts identified january august residential commercial industrial electricity markets genetic algorithm applied analyze clusters evolution results show correlations electricity prices increased continually three departments however decreased confirms sensitivity fuel market besides four regime shifts exist three departments though different times occurrence caused price level fluctuation community evolution consistent four regime shifts final part summary research analyzed results elsevier ltd rights reserved
rapid transport water solutes desiccation soil cracks lead crop water nutrient stress challenge irrigation management cracking soils take advantage rapid water intake rate dry cracked soil keeping plant water stress minimum therefore mitigation suppression desiccation cracks imperative considered objective study laboratory experiment carried investigate effects sugarcane pith additive mitigating desiccation cracks volumetric shrinkage strain total porosity water retention field capacity clay soils clay soil treated sugarcane pith dosages dry weight basis various experimental methods used determine variations volumetric shrinkage total porosity water retention field capacity characteristics crack patterns studied using image processing technique compared untreated soil results showed sugarcane pith increase total porosity water content field capacity reducing volumetric shrinkage strain consequently mitigating development desiccation cracks therefore results suggested modification clayey soil addition sugarcane pith rates dry weight basis viable innovative method mitigate development desiccation cracks addition application enhance recycling efforts converting sugarcane pith waste usable amendment mitigate cracks clayey soil elsevier rights reserved
newborns prone fungal infections largely due candida species immunological basis vulnerability yet fully understood however useful insights gained knowledge maturation immune pathways ontogeny particularly placed context rare genetic mutations humans predispose fungal diseases article review current data immune functions human newborns highlighting pathways relevant response candida discussing data propose framework deficiencies pathways make newborns particularly vulnerable opportunistic pathogen
background arthroscopy established gold standard diagnostic investigation detection shoulder disorders aimed compare diagnostic accuracy arthroscopy magnetic resonance arthrography mra detection shoulder disorders methods patients underwent arthroscopy single surgeon preoperative mra february march shoulder instability identified mras reported experienced musculoskeletal radiologists labral tears anterior labral tears superior labral anterior posterior slap lesions posterior labral tears rotator cuff tears rcts osteoarthritis loose bodies hill sachs lesions identified sensitivity specificity positive predictive value negative predictive value positive likelihood ratio negative likelihood ratio calculated results total patients identified sensitivity specificity anterior labral tears slap lesions posterior labral tears labral tear hill sachs lesions rcts osteoarthritis loose bodies respectively positive predictive value negative predictive value anterior labral tears slap lesions posterior labral tears labral tear hill sachs lesions rcts osteoarthritis loose bodies respectively conclusions mra high diagnostic accuracy labral tears hill sachs lesions whether mra first line imaging modality controversial
data produced wearable sensors key contexts performance enhancement training help sports fitness continuous monitoring aging people chronic disease management gaming entertainment unfortunately wearable devices currently market either incapable complex functionality severely impaired short battery lifetime work present smartwatch platform based ultralow power ulp heterogeneous system composed msp microcontroller pulp programmable parallel accelerator set ulp sensors including camera embedded pulp accelerator enables state art context classification based convolutional neural networks applied within sub system power envelope methodology enables reach high accuracy context classification five classes three classes five reaching accuracy consuming per classification ultralow energy consumption less per classification accuracy xbetter chance results suggest proposed heterogeneous platform provide speedup respect msp within similar power envelope would enable complex computer vision algorithms executed highly power constrained scenarios
retrieval strategy disruption hypothesis basden basden bryner thomas widely cited theoretical explanation memory performance collaborative groups inferior pooled performance individual group members remembering alone collaborative inhibition theory also predicts several variables moderate collaborative inhibition meta analysis tests veracity theory systematically examining whether variables moderate presence strength collaborative inhibition total effect sizes studies included analysis collaborative inhibition found robust effect moreover enhanced remembering took place larger groups uncategorized content items retrieved group members followed free flowing free order procedures group members know one another findings support retrieval strategy disruption hypothesis general theoretical explanation collaborative inhibition effect several additional analyses also conducted elucidate potential contributions cognitive mechanisms collaborative inhibition results suggest contribution retrieval inhibition possible failed find evidence suggest retrieval blocking encoding specificity impact upon collaborative inhibition effects separate analysis effect sizes moderating factors postcollaborative memory performance examined generally collaborative remembering tends benefit later individual retrieval moderator analyses suggest reexposure study material may partly responsible postcollaborative memory enhancement applied implications meta analyses discussed
study compares spinal volumetric bone mineral density vbmd spinal areal bone mineral density abmd among young adults eastern provincial capital cities mainland china total young adults age range eastern provincial capital cities beijing shanghai guangzhou mainland china recruited study subject vbmd lumbar spine measured mindways quantitative computed tomography system moreover abmd lumbar spine measured dual energy ray absorptiometry extracted previous multicenter large scale study participants matched age gender height weight well geographic territory vbmd abmd values compared analyzed generally bone mineral density bmd results significantly different among participants cities specifically vbmd abmd values participants beijing significantly different guangzhou interestingly overall mean vbmd value greater women men cities study demonstrated overall heterogeneity spinal bmd among young adults eastern provincial capital cities mainland china specifically taller heavier young adults northern part china smaller spinal vbmd higher spinal abmd values shorter lighter southern part china
ionic mixtures measured specific conductivity increasingly concerned toxicities aquatic organisms however identifying protective values specific conductivity aquatic organisms challenging given laboratory test systems examine salt intolerant species effects occurring streams large data sets used deriving field based benchmarks rarely available study field based method small data sets used derive specific conductivity benchmark expected prevent extirpation local taxa circum neutral alkaline waters dominated mixture hco anions dissolved ions compensate smaller sample size species level analyses combined genus level analyses benchmark based extirpation concentration values specific conductivity macroinvertebrate genera estimated sampling sites hun tai river basin derived specific conductivity benchmark using point interpolation method yielded benchmark study tailored method developed usepa derive aquatic life benchmark specific conductivity basin scale application may provide useful information water pollution control management elsevier ltd rights reserved
background according present evidences suggesting association low testosterone level prediction reduced exercise capacity well poor clinical outcome patients heart failure sought determine testosterone replacement therapy trt improves clinical cardiovascular conditions well quality life status patients stable chronic heart failure chf methods carried review based published clinical trials determine whether trt benefit patients chf information exercise capacity hemodynamic parameters electrocardiogram indicators muscle strength echocardiography guidelines laboratory indexes collected assess clinical outcomes results found trt could improve significantly exercise capacity muscle strength electrocardiogram indicators significant changes ejection fraction systolic blood pressure sbp diastolic blood pressure dbp terminal pro brain natriuretic peptide probnp tumor necrosis factor alpha tnf alpha high sensitivity reactive protein crp interleukin conclusions high quality studies required better understand clinical effects testosterone
smart metering allows electricity utilities provide consumers better information energy usage apply time use pricing measures shown reduce electricity consumption induce time shifting demand less known affect residential energy efficiency investment behaviour use data randomised controlled trial sample almost irish consumers conducted month period investigate effect smart metering residential feedback household investment behaviour results show exposure time use pricing information stimuli reducing overall peak usage also unintended effect reducing investment energy efficiency measures within home findings indicate households exposed treatment less likely adopt energy saving measure average households adopted less energy saving features control group average result highlights potential behavioural interventions unintended consequences behaviours specifically targeted furthermore underlines importance examining wider range outcomes allowing longer time scales evaluating type experiment
shift memory data processing paradigm major influence development cluster data processing frameworks numerous frameworks industry open source community academia adopting memory paradigm achieve functionalities performance breakthroughs however despite advantages memory frameworks practice susceptible memory pressure related performance collapse failures contributions paper twofold first conduct detailed diagnosis memory pressure problem identify three preconditions performance collapse preconditions explain problem also shed light possible solution strategies second propose novel programming abstraction called leaky buffer eliminates one preconditions thereby addressing underlying problem implemented leaky buffer enabled hashtable spark believe also able substitute hashtable performs similar hash aggregation operations programs data processing frameworks experiments range memory intensive aggregation operations show leaky buffer abstraction drastically reduce occurrence memory related failures improve performance percent reduce memory usage percent
introduction hospitalists working united states limited empiric research performed characterize clinical excellence hospital medicine conducted qualitative study discover elements judged pertinent excellence clinical care delivered hospitalists methods chiefs hospital medicine five hospitals asked identify clinically best hospitalists data collection form one one interviews directed interview guide interviews transcribed verbatim informants perspectives analyzed using editing analysis identify themes results total hospitalists interviewed mean age physicians years women non white seven themes emerged related clinical excellence hospital medicine communicating effectively appreciating partnerships collaboration superior clinical judgment organized efficient connecting patients committing continued growth development professional humanistic discussion qualitative study describes respected hospitalists think excellence clinical care hospital medicine perspectives used guide continuing medical education offered programs pay attention enhancing skills learners develop towards excellence rather using competence desired target objective
paper summarises properties linear systems described differential algebraic equations dae systems derives conditions dae systems equivalently represented state space model ode systems index introduced important parameter role explained examples
recent cardiovascular outcome trials leader liragutide sustain semaglutide shown significant reductions major cardiovascular events glucagon like peptide glp receptor agonists progressive separation treatment placebo curves starting clearly months trial period significant reductions risk myocardial infarction stroke indicate beneficial effects observed glp receptor agonists could due antiatherogenic effect far reasons effect glp receptor agonists entirely clear although several hypotheses may proposed reductions glycated haemoglobin systolic blood pressure sbp trials modest trials lasted short period time reductions hyperglycaemia sbp unlikely involved beneficial effects glp receptor agonists hand effect lipids particular dramatic decrease postprandial hypertriglyceridaemia may explain beneficial actions reduction body weight including significant decrease visceral fat patients using glp receptor agonists may also beneficial effects reducing chronic proatherogenic inflammation addition vitro data showing direct anti inflammatory effect agents could also involved beneficial effects moreover studies humans shown significant beneficial effects ischaemic myocardium short treatment period suggesting direct effect glp receptor agonists myocardium although precise mechanism remains unclear finally reduction insulin resistance associated decrease risk ruled lowering insulin resistance induced glp receptor agonists might also involved beneficial actions elsevier masson sas rights reserved
process aware information systems pais support business processes generate large amounts event logs execution business processes event log represented tuple caseid timestamp activity actor process mining new emerging field aims analyzing event logs discover enhance improve business processes check conformance run time design time business processes large volume event logs generated stored databases relational databases perform well certain class applications however certain class applications relational databases able scale well address challenges scalability nosql database systems emerged discovering process model workflow event logs one challenging important process mining tasks miner algorithm one first widely used process discovery techniques objective investigate databases relational nosql performs better process discovery application process mining implement miner algorithm relational row oriented nosql column oriented databases database query languages application tightly coupled database conduct performance benchmarking comparison miner algorithm row oriented database nosql column oriented database present comparison various aspects like time taken load large datasets disk usage stepwise execution time compression technique
background solid organ transplant sot recipients risk nocardiosis rare opportunistic bacterial infection prognosis outcome patients poorly defined objectives identify factors associated year mortality nocardiosis describe outcome patients receiving short course antibiotics days methods analyzed data multicenter european case control study included sot recipients nocardiosis diagnosed factors associated year cause mortality identified using multivariable conditional logistic regression results one year mortality fold higher patients nocardiosis control transplant recipients history tumor odds ratio confidence interval invasive fungal infection donor age independently associated year mortality acute rejection year nocardiosis associated improved survival seventeen patients received short course antibiotics median duration days year success rate cured surviving risk relapse median follow months conclusions one year mortality fold higher sot patients nocardiosis without four factors largely reflecting general medical condition rather severity management nocardiosis independently associated year mortality patients received short course antibiotic treatment good outcomes suggesting may strategy study
today network distributed heterogeneous nature numerous applications affect day day life banking booking tickets line shopping etc hence security network crucial threats network due intrusions threats observed handled using intrusion detection system security achieved using intrusion detection system observes data traffic identifies intrusion objective paper design model using game theoretic approach intrusion detection game model designed defining players strategies utility functions identify probe attacks model tested nslkdd data set model probe attacks identified dominated strategies elimination method experimental results shows game model identifies attacks good detection rate
background objectives children atopic dermatitis increased risk general behaviour problems specific condition treatment hamper ability parents carry treatment manage condition effectively date published instrument available assess child behaviour difficulties context atopic dermatitis management aim develop reliable valid instrument assess atopic dermatitis specific child behaviour problems parents self efficacy confidence managing behaviours methods eczema behaviour checklist ebc developed item questionnaire measure extent behaviour problems ebc extent scale parents self efficacy managing behaviour problems ebc confidence scale context child atopic dermatitis management community based sample parents completed ebc measures general behaviour difficulties self efficacy atopic dermatitis management use dysfunctional parenting strategies results satisfactory internal consistency construct validity ebc extent confidence scales negative correlation atopic dermatitis specific behaviour problems parents self efficacy dealing behaviours factor analyses revealed three factor structure scales treatment related behaviours symptom related behaviours iii behaviours related impact illness variation parents self efficacy managing child atopic dermatitis explained intensity illness specific child behaviour problems parents self efficacy dealing behaviours conclusions new measure atopic dermatitis specific child behaviour problems stronger predictor parents self efficacy managing child condition measure general child behaviour difficulties results provide preliminary evidence reliability validity ebc potential use clinical research settings warrant psychometric evaluation
nowadays electronic throttle control system widely adapted motorcycle better drivability fuel economy reduces emissions systems pedal follower torque based approach used calculating required throttle angle given torque demand driver work presents throttle control system precise estimation throttle angle based integrated pedal follower torque based approach given accelerator position torque demand driver mathematical model electronic throttle body developed understand effects nonlinearities due friction limp home dual springs pid controller compensators developed handle nonlinearities due friction limp home dual springs proposed electronic throttle control system simulation study carried using software loop hardware loop simulation approaches step sinusoidal ramp input signals responses electronic throttle body opening throttle angle error analyzed given input signals simulation result shows proposed compensators significant advantage reducing throttle angle error gives desired output
pre schools primary schools play prominent role lives children phase life reading writing would begin studies explored relationships writing reading performance furniture classroom considerable body research addresses role school furniture children health nevertheless impact furniture behaviour received fairly insufficient attention design furniture industries since children choice selecting furniture ended becoming passive users design process paper aim understand impacts school furniture children health performance paper reviews previous studies children furniture educational centers order introduce new prototype school furniture study could inform designers involved children related educational systems develop better furniture designs schools
nonlinear control strategy enhance transient stability voltage regulation single machine infmite bus smib static var compensator svc connected transmission line explained part advanced course materials power lines design generator excitation svc regulator controllers designed independently considering uncertainties generator structure interconnection subsystems perturbations high order sliding mode hosm control scheme developed purpose obtaining robustness presence uncertainties parameter variations numerical simulations developed work provide innovative training tool teachers area automatic control materials engineering expand understanding underlying dynamics control systems
continuation previous work paper focus cauchy problem two dimensional incompressible boussinesq equations fractional laplacian dissipation give elementary proof global regularity smooth solutions boussinesq equations new range fractional powers laplacian argument based nonlinear lower bounds fractional laplacian established consequently result significantly improves recent works elsevier inc rights reserved
economical portable line motor condition monitoring system based advanced microprocessor graphic user interface abnormality detection described electrical vibrational signal analysis fault detection motors applied cortex microcontroller built high speed analog digital converter used process line voltage current vibration signals motors operation acquired signals digitally filtered infinite impulse filter fast fourier transform spectral analysis applied abnormal pattern recognition analytic results displayed real time embedded touch screen monitor instantly provide users motor operational conditions finally prototype devised verified onsite experimentation comparing results commercial tools showed similar spectral characteristics difference electrical vibration signals less thus system proposed shows promising ability feasibility online use elsevier ltd rights reserved
neonatal line usually first accentuated incremental line visible enamel prenatal environment significantly contributes width neonatal line influencing pace reaching post delivery homeostasis newborn organism studies enamel earliest developing deciduous teeth provide insight prenatal development perinatal conditions children past human populations thus additional source contributing consideration influence prenatal perinatal factors modifying growth processes aim study examine whether neonatal line reflecting conditions prenatal perinatal environment differed neolithic mediaeval modern populations kujawy region north central poland material consisted longitudinally ground sections human deciduous incisors obtained children aged years representing three archaeological series brzesc kujawski site teeth sectioned labio linqual plane using diamond blade buechler isomet final specimens observed microscope delta optical evolution magnifications tooth linear measurements neonatal line width performed labial surface three levels cemento enamel junction significant difference found mean neonatal line width depending tooth type archaeological site although thickest neonatal line characterised children neolithic series analysed series neonatal line width diversified depending child age death value spearman rank correlation coefficient calculated correlation child age death neonatal line width statistically significant clear increase width neonatal line thus observed along decrease child age death elsevier gmbh rights reserved
dopamine receptor plays important part human central nervous system considered focal target antipsychotic agents structurally modeled active inactive states homodimerization reaction monomers also applied asp also known acr ligand stabilizer used tests evaluate dimerization conformational changes may alter ligand binding space provide information alterations inhibitory mechanisms upon activation administration agonist ligand acr propy hexahyd naphtho oxazin phno revealed values high iow calculated binding affinities acri post processing molecular dynamics simulations analyses using pbsa monomeric homodimeric forms high kcal mol respectively data suggests dimerization leads negative cooperativity acr binding dimerization reaction high energetically favorable kcal mol dimerization reaction structurally thermodynamically stabilizes high conformation may due intermolecular forces formed monomer result strongly demonstrates dimerization essential activation
aim naturalistic clinical study patients early stages bipolar disorders aim assess differences patients bipolar bipolar disorders clinical characteristics including affective symptoms subjective cognitive complaints functional level presence comorbid personality disorders coping strategies methods diagnoses confirmed using structured clinical interview dsm disorders clinical symptoms rated young mania rating scale hamilton depression rating scale functional status using functional assessment short test cognitive complaints assessed using massachusetts general hospital cognitive physical functioning questionnaire presence comorbid personality disorders using standardized assessment personality abbreviated scale coping style using coping inventory stressful situations results total patients included patients presented significantly depressive symptoms cognitive complaints lower overall functioning higher prevalence comorbid personality disorders finally exhibited trend towards using less adaptive coping styles limitation omitted patients may progressed measures based patient self report conclusions overall associated higher disease burden clinically important differentiate research wise need tailoring testing specific interventions towards
owing rapid development earth observation technology volume spatial information growing rapidly therefore improving query retrieval speed large rich data sources remote sensing data management systems quite urgent global subdivision model geographic coordinate subdivision grid one dimension integer coding tree propose solution used data management organizations however spatial object may cover several grids ample data redundancy occur data stored relational databases solve redundancy problem first combined subdivision model spatial array database containing inverted index proposed improved approach integrating managing massive remote sensing data adding spatial code column array format database spatial information remote sensing meta data stored logically subdivided implemented method kingbase enterprise server database system compared results oracle platform simulating worldwide image data experimental results showed approach performed better oracle terms data integration time space efficiency approach also offers efficient storage management system existing storage centers management systems society photo optical instrumentation engineers spie
objectives objectives study evaluate long term effects orchidectomy low testosterone craniofaciodental development maintenance skeletal oral health rhesus macaques materials methods mandibles four castrated intact age matched male rhesus monkeys macaca mulatta cayo santiago compared mandibular morphology teeth abnormalities pathology cortical bone thickness density using digital sliding caliper analysis three dimensional ray images results although four castrates generally comparable intact males overall mandible teeth size significant differences castrates distance two rami narrower intact males leading relatively narrower longer face mandibular body ramus thinner cortical bone leading less total bone mass canines molar teeth slender lower less robust tooth cusps addition alveolar bone two geriatric castrates greatly receded signs periodontitis severe intact aged males old castrates also severe temporomandibular joint osteoarthritis discussion findings suggest importance testosterone craniofaciodental development maintenance skeletal oral health male macaques results suggest dental health professionals might want include medical history questionnaires whether male patients taken hormone testosterone replacement therapy wiley periodicals inc
paper focuses design new automatic landing system als longitudinal plane new als controls aircraft trajectory longitudinal velocity aircraft control achieved means proportional integral controller instrumental landing system first phase landing glide slope proportional integral derivative pid controller together radio altimeter second phase landing flare controllers modify reference model associated aircraft pitch angle control pitch angle longitudinal velocity performed neural network adaptive control system based dynamic inversion concept following components linear dynamic compensator linear observer reference models pseudo control hedging pch block theoretical results software implemented validated complex numerical simulations compared alss radio technical subsystems conventional fuzzy controllers control aircraft pitch angle longitudinal velocity architecture designed paper characterized much smaller overshoots stationary errors chinese society aeronautics astronautics production hosting elsevier ltd open access article theccby license
background previous studies shown topical corticosteroid tcs use induces structural abnormalities stratum corneum resulting permeability barrier disruption well known epidermal barrier perturbation induces cytokine cascade leading cutaneous inflammation accordingly hypothesize barrier disruption caused long term tcs therapy may trigger cutaneous cytokine cascade plays important role withdrawal dermatitis following discontinuation tcs objective study elucidate possible mechanism methods hairless mice treated daily betamethasone dipropionate ointment weeks discontinuation tcs examined transepidermal water loss tewl lipids expression cytokines interleukin alpha ili alpha tumor necrosis factor alpha tnf alpha downstream signaling pathway following weeks results observed upregulation ili alpha tnf alpha inhibitor nuclear factor kappa kinase subunits alpha beta ikk ikk nuclear factor kappa kappa epidermis accompanied significantly higher tewl tcs cessation cytokines gradually disappeared concomitant normalization tewl week negligible amounts aforementioned cytokines observed dermis furthermore concurrent application petrolatum tcs treatment decreased barrier impairment production cytokines conclusion epidermis derived cytokine cascade observed following tcs induced barrier disruption similar permeability barrier insults acetone tape stripping study suggests concurrent application skin care products tcs treatment improves barrier homeostasis become standard practice alleviate tcs induced copyright taiwanese dermatological association published elsevier taiwan llc rights reserved
submodular function minimization key problem wide variety applications machine learning economics game theory computer vision many others general solver complexity log log time required evaluate function number variables lee hand many computer vision machine learning problems defined special subclasses submodular functions written sum many submodular cost functions defined cliques containing variables functions pseudo boolean polynomial representation boros hammer subclasses degree order clique size work develop efficient algorithms minimization useful subclass submodular functions define novel mapping transform submodular functions order quadratic ones underlying idea use auxiliary variables model higher order terms transformation found using carefully constructed linear program particular model auxiliary variables monotonic boolean functions allowing obtain compact transformation using auxiliary variables possible transformed quadratic function efficiently minimized using standard max flow algorithm time complexity total number auxiliary variables involved transforming higher order terms quadratic ones specifically show approach fourth order function requires auxiliary variables contrast variables used existing approaches general case give art upper bound number auxiliary variables required transform function order using dedekind number substantially lower existing bound elsevier rights reserved
fastener assembly tedious time consuming work operators check assembly manuals find right fastener hole hence paper aims develop three dimensional projection system projects assembly instruction onto work piece surface directly guide operators assemble however order project instruction accurately corresponding part computer aided design model physical scanned area needs attained rapid accurate registration order achieve goal first high accuracy rapid measurement system developed second fast registration method based local multiscale geometric feature vector proposed accelerate registration speed improve registration reliability experimental results demonstrate measurement accuracy developed system verify feasibility proposed registration method hence proposed method lead improved assembly efficiency decreased error probability making great contributions large scale structure assembly
little known patterns mechanisms humanitarian emergencies may exacerbate violence children article propose using ecological framework examine impact humanitarian emergencies interpersonal violence children consider literature supports framework suggest future directions research fill identified gaps framework relationship humanitarian emergencies violence children depends risk factors multiple levels including breakdown child protection systems displacement threats livelihoods changing gender roles changing household composition overcrowded living conditions early marriage exposure conflict emergency events alcohol abuse empirical evidence supporting proposed emergency violence framework limited cross sectional study designs propensity predominantly examine individual level determinants violence especially exposure conflict emergency events thus pressing need contextualize relationship conflict emergency events violence children within wider ecological household dynamics occur humanitarian emergencies ultimately require longitudinal observations children families communities emergency recovery improvements ongoing global surveillance systems complete data enable humanitarian community design effective appropriate well targeted interventions
background electrocardiographic ecg monitored outpatient cardiac rehabilitation routinely performed following variety cardiovascular procedures conditions objective aim study determine diagnostic quality ecg monitoring patients coronary artery disease cad useful identifying asymptomatic myocardial ischemia resulting change care medical management methods retrospective analysis ecg monitoring done patients diagnosed cad january june results nearly quarter patients displayed least asymptomatic segment depression milliseconds point least session patients medical management change compared show ecg changes suggesting ischemia patients asymptomatic ischemia medical management change resulted directly staff detection fewer patients diagnosed myocardial infarction coronary artery bypass graft surgery demonstrated ecg signs ischemia whereas patients diagnosed stable angina percutaneous coronary interventions demonstrated ecg signs ischemia conclusion study demonstrates patients cad showing asymptomatic ecg signs suggesting ischemia undergo medical management change result finding diagnostic quality ecg monitoring appears warranted population
paper proposes new lightweight cipher vayu vayu balanced feistel structure vayu cipher supports bit plaintext bit key length total rounds needs ges bit key length also results minimal memory size compared existing lightweight ciphers paper discusses security analysis vayu cipher design adequate linear differential cryptanalysis biclique attack zero correlation attack algebraic attack vayu cipher design best suitable applications like iot smart wireless sensor networks vayu cipher uses two functions substitution box results high diffusion mechanism
purpose reviewto examine role testosterone skeletal health men recent findingsevidence recent studies shows contributing role testosterone osteoporosis modest likely trumped factors estradiol levels studies documented association low testosterone levels lower bone mineral density bmd increased prevalence osteoporosis hip low bone mass related fractures studies however found testosterone levels independent predictors bone resorption formation markers bmd hip incident fractures curiously hypogonadism account increased osteoporosis seen men klinefelter syndrome regardless hypogonadism status two recent clinical trials found fewer new morphometric vertebral fractures men treated zoledronic acid increased bmd men treated denosumab denosumab also shown modestly increase bone metastasis free survival men castration resistant prostate cancer summaryalthough male hypogonadism associated osteoporosis estradiol likely important hormone bone health although large randomized controlled trials conducted men low bone density subset hypogonadism trials needed particularly fractures main outcome
article addresses problem creating interactive mixed reality applications virtual objects interact images real world scenarios relevant create games architectural space planning applications interact visual elements images walls floors empty spaces scenarios intended captured users regular cameras using previously taken photographs introducing virtual objects photographs presents several challenges pose estimation creation visually correct interaction virtual objects boundaries scene two main research questions addressed article include study feasibility creating interactive augmented reality applications virtual objects interact real world scenario using image detected high level features also verifying untrained users capable motivated enough perform initialization steps proposed system detects scene automatically image additional features obtained using basic annotations user operation significantly simple accommodate needs non expert users system analyzes one photos captured user detects high level features vanishing points floor scene orientation using features possible create mixed augmented reality applications user interactively introduces virtual objects blend picture real time respond physical environment validate solution several system tests described compared using available external image datasets
article employs boden understanding creativity defined terms big creativity associated high culture small creativity concerned constructive life affirming strategies comparative study films quartet youth focusing representations ageing artists musicians ways film suggests life experience informs artistic endeavour vice versa film based varying scenarios late life big creativity article explores contrasts small creativity suggested storylines article argues varying degrees different ideological implications film points importance relationality embodiment late life creativity
study presents new method computes analytical fragility curves structure subject tsunami waves method uses dynamic analysis stage computation first smooth particle hydrodynamics sph model simulates propagation tsunami waves shallow water impact target structure advantage sph mesh based methods capability model wave surface interaction large deformations involved impact water structure although sph computationally expensive mesh based method nowadays advent parallel computing general purpose graphic processing unit overcome limitation impact force applied finite element model structure dynamic non linear response computed data set tsunami waves used analytical fragility curves computed study proves possible obtain response structure tsunami wave using state art dynamic models every stage computation affordable cost
traditional framework mandatory access control mac system malicious software run kernel mode malicious software stop mac systems started make invalid problem solved traditional framework operating system comprised since malwares running ring level paper propose novel way use hypervisors protect kernel integrity access control system commodity operating systems separate access control system three parts policy management security server policy enforcement policy management security server reside security domain protect malware isolation feather hypervisor protect attacks add access vector cache avc guest order speed communication guest security domain policy enforcement module retained guest performance security avc ensured using memory protection mechanism goal protecting kernel ensure security execution path implement system modified xen hypervisor result shows secure security access control system guest overhead compared modules latter system offers centralized security policy virtual domains virtual machine environments
capability adult child witnesses accurately recollect events past provide reliable testimony hotly debated years prominent legal cases sparked lengthy debates important research questions surrounding fallibility general reliability memory lessons learned years later role memory judicial system review focus know consequences fallibility memory legal proceedings present brief historical overview false memories focuses three critical forensic areas changed memory research children eyewitnesses historic sexual abuse eyewitness mis identification revisit prominent trials consider role false memories played judicial decisions also see helped understand memory today finally consider way research memory true false successfully integrated courtroom procedures
objective study explored attitudes experience menopause among macedonian women living australia including attitudes responses hormone therapy complementary therapies well related psycho sexual relationship midlife issues methods using qualitative methodology study based seven unstructured nondirective group discussions natural social groups recruited meeting wherever group felt home total participants ranged age years women included first generation immigrants women born australia macedonian parents bilingual macedonian researcher conducted fieldwork results participants typically claimed lacked information menopause native language knowledge highly variable women felt comfortable approaching macedonian doctors others reported easing symptoms revisited homeland deeply religious participants claimed faith helped phase life likely consult priest doctor recurring theme macedonian men tended regard wives differently menopause sometimes treating non sexual women regarded shift male attitudes precipitating factor domestic violence extramarital affairs divorce symptoms hot flashes mood swings associated negative attitudes toward menopause conclusions culturally determined attitudes appear affect perception experience menopause influencing factors include migration women roles marital status religion use herbal traditional remedies social situation access information knowledge experience menopausal symptoms
frequent widespread use pesticides agriculture adversely affects biodiversity human health water quality french government adopted environmental policy plan ecophyto halve pesticide use within years trends synthetic pesticide sales use france described three different indicators number unit doses nud quantity active ingredient qai treatment frequency index tfi changes pesticide use seven principal arable crops france since implementation policy plan analyzed together impact changes pesticide use water quality evidence found decrease pesticide sales national level terms tfi values individual crops decrease pesticide use observed since soft wheat decrease slight pesticide use decline rapidly changes pesticide use differed french regions crops water pollution decrease period studied possible explanations lack effectiveness french environmental plan considered context european legislation elsevier rights reserved
extensive body research suggests spontaneous eye blink rate ebr non invasive indirect marker central dopamine function higher ebr predicting higher function present review provide comprehensive overview literature broadly divide available research studies aim disentangle dopaminergic underpinnings ebr investigate utility diagnosis related disorders responsivity drug treatment lastly investigate ebr predictor individual differences related cognitive performance conclude ebr reflect receptor subtype activity although baseline ebr might strongly related latter ebr predict hypo hyperdopaminergic activity well normalization activity following treatment iii ebr reliably predict individual differences performance many cognitive tasks particular related reward driven behavior cognitive flexibility sum review establishes ebr useful predictor wide variety contexts elsevier ltd rights reserved
randomized controlled trial aims test efficacy group intervention free women overweight obesity based mindfulness act compassion approaches intervention aimed reduce weight self stigma unhealthy eating patterns increase quality life qol seventy three women aged years old bmi without binge eating seeking weight loss treatment randomly assigned intervention control groups free comprises weeldy group sessions plus booster fortnightly sessions control group maintained treatment usual tau data collected baseline end free intervention overall participants enrolled free found intervention important helpful dealing weight related unwanted internal experiences moreover compared tau free group revealed significant increased health related qol physical exercise reduction weight self stigma unhealthy eating behaviors bmi self criticism weight related experiential avoidance psychopathological symptoms post treatment results self compassion showed trend towards significance whereas significant groups differences found mindfulness taken together evidence found free efficacy reducing weight related negative experiences promoting healthy behaviors psychological functioning qol elsevier ltd rights reserved
objectives healthcare expenditures united states increased exponentially hospital care accounts one third costs approximately hospitalized medicare beneficiaries readmitted hospital within days engaging patients discharge process help better identify patients postdischarge needs implement effective readmission prevention strategies objective study identify factors contribute hospital readmission seen patients perspectives large urban community hospital methods evaluated consecutive unplanned readmissions hospitalist service within days discharge using state action avoidable rehospitalizations diagnostic worksheet face face patient interviews retrospective chart reviews results study period patients readmitted within days discharge one readmission mean age years patients men black sickle cell disease leading diagnosis index admissions readmissions patient interviews identified modifiable risk factors readmissions inability obtain medications schedule follow appointments well problems related transportation housing social support despite clear discharge planning patient understanding plan recorded discharge almost one third patients appeared lack ability self manage symptoms understand disease process conclusions study demonstrated engaging patients discharge planning help identify barriers within process improvements socioeconomic environmental layers population health potential prevent hospitalizations readmissions long term
background concerns regarding topical corticosteroid tcs use broadly known corticophobia highly prevalent among dermatology patients often result non adherence tcs non adherence contributes poor disease control increased health care costs however unknown assessment concerns might help identify patients risk tcs non adherence clinical tools indicating non adherence could helpful improve management patient group objective assess whether available tools measuring concerns regarding corticosteroids topicop scale visual analogue scale vas could help detect non adherence tcs methods patients concerns regarding tcs use topicop scale vas anonymously assessed comparison made tcs adherent non adherent patients regarding intensity characteristics concerns results intensity quality concerns varied broadly among patients using vas score detected non adherent patients answers topicop scale discriminate non adherent adherent patients conclusion using vas assess concerns use tcs could help identify patients risk tcs non adherence facilitate discussion patient potential non adherence substantiated non judgemental way
background exocrine pancreatic insufficiency epi characterized deficiency exocrine pancreatic enzymes resulting malabsorption numerous conditions account etiology epi common diseases pancreatic parenchyma including chronic pancreatitis cystic fibrosis history extensive necrotizing acute pancreatitis treatment epi includes dietary management lifestyle changes decrease alcohol consumption smoking cessation pancreatic enzyme replacement therapy discussion many diagnostic tests available diagnose epi however criteria choice remain unclear causes false positive test yet understood despite multiple studies treatment epi using exogenous pancreatic enzymes remains confusion amongst medical practitioners regard best approach diagnose epi well dosing administration pancreatic enzymes summary appropriate use diagnostics treatment approaches using pancreatic enzymes epi essential patients opinion piece aims address existing myths remove current confusion function practical guide diagnosis treatment epi
facial expression reconstruction important issue field computer graphics relatively easy create animation based meshes constructed video recordings kind high quality data often transferred another model lack intermediary anthropometry based way however high quality mesh sampled sufficient density possible use obtained feature points encode shape surrounding vertices way easily transferred another mesh corresponding feature points paper present method used obtaining information purpose reconstructing changes facial surface basis selected feature points
background hereditary angioedema inhibitor deficiency inh hae rare inherited genetic disease characterized recurrent swelling episodes skin gastrointestinal tract upper airways angioedema attacks result increased vascular permeability due release bradykinin high molecular weight kininogen currently biomarkers predicting frequency angioedema attacks vascular permeability modulated several factors including vascular endothelial growth factors vegfs angiopoietins angs increased circulating levels vegfs angs observed diseases associated higher vascular permeability systemic capillary leak syndrome sepsis sought analyze plasma concentrations vegfs angs patients inh hae methods sixty eight healthy controls patients inh hae studied concentrations angiogenic vegf ang ang anti angiogenic vegf lymphangiogenic vegf factors evaluated elisa inh functional activity assessed eia results plasma concentrations vegf vegf ang ang higher patients inh hae remission healthy controls concentration vegf increased patients lower inh functional activity patients inh hae experiencing angioedema attacks per year characterized higher plasma levels vegf vegf ang compared patients conclusions hypothesize vegfs angs induce state vascular preconditioning may predispose angioedema attacks addition identification increased plasma levels vegfs angs patients inh hae may prompt investigation vegfs angs biomarkers inh hae severity
pulsatile secretion gonadotropin releasing hormone gnrh luteinizing hormone decreases aging kisspeptin encoded kiss neurons arcuate nucleus coexpress neurokinin tac dynorphin pdyn critical regulating gnrh pulse therefore examined kisspeptin neurons histochemistry pulsatile release rats aged young youngmiddle late middle old months total concentrations sampled hours decreased sexes aging females numbers tac pdyn neurons significantly reduced aging rats numbers kiss neurons significantly reduced late middle old rats males numbers neuron types significantly decreased aging rats gnrh agonist induced release animals however increased concentration aging rats less young rats results suggest expression gene kisspeptin neurons may controlled individually aging reduction expression change pituitary responsiveness may cause attenuated pulsatile secretion elsevier inc rights reserved
purpose aim study describe nocturia without leakage population patients multiple sclerosis materials methods retrospective single center study patients multiple sclerosis followed experienced neurourology center patients daytime urinary symptoms associated disorder among patients nocturia groups defined including isolated nocturia without nocturnal urinary incontinence patients nocturia associated nocturnal urinary incontinence control group comprised patients without nocturia clinical variables urodynamic data studied gender age edss expanded disability status scale usp urinary symptoms profile questionnaire overactive bladder score bladder capacity detrusor activity volume first detrusor contraction results patients nocturia including nocturnal urinary incontinence average usp overactive bladder score statistically greater patients nocturia controls mean maximum cystometric capacity statistically higher control group patients nocturia similar outcome found first contraction mean conclusion isolated nocturia nocturnal urinary incontinence frequent problem encountered multiple sclerosis results suggest overactive detrusor main mechanism studies needed verify complications arising nocturia
background fracture complex trait affected genetic environmental factors meta analysis genome wide association studies gwass identified multiple bone mineral density bmd fracture associated loci objective conducted study evaluate whether fracture genetic risk score grs bone mineral density genetic risk score bmd grs modify association intake calcium vitamin cad fracture risk design data white postmenopausal women women health initiative cad randomized trial included participants received elemental vitamin placebo median follow total fracture defined first fracture type computed grs fracture bmd associated variants bmd grs bmd associated variants used cox regression caseonly approach test multiplicative interaction additive interaction assessed relative excess risk due interaction reri analyzed genetic risk score continuous variable categorical variable based quartile quartile quartiles quartile results observed interaction grs cad fracture risk however observed significant multiplicative interaction bmd grs cad assignment interaction addition significant negative additive interaction placebo assignment higher bmd grs quartiles reri quartile preri stratified analysis protective effect cad fracture risk observed women lowest bmd grs quartile women higher bmd grs conclusions observed significant effects cad intake fracture risk women lowest genetic predisposition low bmd future large scale studies functional characterization gwas findings warranted assess utility genetic risk score analysis risks benefits cad bone
number local minima potential energy landscape pel molecular systems generally grows exponentially number degrees freedom crucial property pel exploration algorithms ability identify local minima low lying diverse work present new exploration algorithm retaining ability basin hopping identify local minima transition based rapidly exploring random trees rrt foster exploration yet unexplored regions ability obtained interleaving calls extension procedures rrt show tuning balance two types calls allows algorithm focus low lying regions computational efficiency obtained using state art data structures particular searching approximate nearest neighbors metric spaces present results bln protein model whose conformational space dimension whose pel studied exhaustively system show propensity algorithm explore low lying regions landscape significantly outperforms rrt wiley periodicals inc
background work related stress evaluated one important health risks europe prevention work related stress interventions reduce risk factors stress workplace conducted together enterprise occupational health services objective aim study examine experiences finnish occupational physicians stress management enterprises methods finnish association occupational health physicians membership list physicians responded self administered anonymous questionnaire data analysed using spss results client enterprises contacted occupational health services frequently work related stress collaboration occupational health enterprises strongest companies occupational health services generally experienced physicians occupational health services enterprises shared responsibility managing work related stress conclusions professional experience close contact organisation management favours successful stress management occupational health enterprises
study aimed determine prevalence clinical depression defined icd criteria patients obstructive sleep apnea osa referred sleep center prospective general sleep evaluations conducted consecutive patients referred sleep center first quarter inclusion criteria apnea hypopnea index ahi completion beck depression inventory bdi score world health organization well index met combined screening criterion bdi eighty one patients underwent psychiatric examination psychiatric sleep specialists sample clinical depression diagnosed complaints existed patients different psychiatric diagnosis prevalence clinical depression according icd criteria selected clinical sample referred sleep center mood scales tend overestimate complaints compared psychiatric consultation interdisciplinary cooperation recommended osa patients symptoms depression depressed patients treatment resistance
backgroundserum total sialic acid tsa concentration regarded indicator risks atherosclerosis cardiovascular diseases association levels atherosclerosis risk factors assessed patients thyroid diseases methodssixty newly diagnosed treatment naive hypothyroid patients subclinical overt hypothyroidism euthyroid individuals analyzed measured fasting blood samples routine biochemical parameters atherosclerosis markers carotid artery intima media thickness cimt resultsmean cimt found higher patient group compared control group mean sialic acid higher overt hypothyroidism patients compared subclinical hypothyroidism patients control group difference found subclinical hypothyroidism group control group sialic acid level cimt positive correlation entire population hypothyroidism group linear regression model established mean cimt level entire population showed risk factors ldl uric acid crp independent predictors cimt level conclusionsialic acid level elevated hypothyroid patients however elevation related thyroid hormone levels autoantibodies correlations atherosclerosis indicators cimt ldl crp uric acid hypothyroid individuals suggest may indicator atherogenesis patients
animal human studies suggest initial expression maternal behaviour depends oxytocin dopamine systems however mechanism systems affect parenting behaviours timing effects well understood article explores role mothers executive function mediating relation oxytocin dopamine gene variants maternal responsiveness months post partum participants mothers recruited maternal adversity vulnerability neurodevelopment study assesses longitudinally two cohorts mothers children canada examined single nucleotide polymorphisms snps related dopamine oxytocin systems drd drd oxtr oxtr assessed mothers decision making months using cambridge neurological automated testing battery cantab evaluated maternal responsiveness videotaped interactions etch sketch operation task mediation analyses showed oxtr carriers indirect effect positive parenting mediated mothers performance decision making task estimate oxtr carriers direct indirect effects physically controlling parenting also mediated enhanced performance decision making estimate oxytocin previously associated early onset maternal behaviour show oxtr polymorphism involved maternal behaviour months post partum mothers executive function research highlights importance oxytocin system maternal parenting beyond infancy
purpose aim study determine whether categories contraception differ impact seizures women epilepsy whether impact varies antiepileptic drug category methods retrospective survey data came contraceptive experiences reported women epilepsy compared risk ratios reports increase decrease seizure frequency hormonal versus nonhormonal contraception stratified antiepileptic drug categories results women epilepsy reported change seizures hormonal nonhormonal contraception risk ratio seizure increase hormonal versus nonhormonal contraception risk ratio seizure decrease hormonal versus nonhormonal contraception hormonal contraception risk ratio seizure increase greater decrease comparison combined pills hormonal patch progestin pills greater risk ratios seizure increase depomedroxyprogesterone hormonal method greater risk ratio seizure decrease combined pills seizure increase greater hormonal nonhormonal contraception antiepileptic drug category hormonal contraception relative non enzyme inducing antiepileptic drug category lowest rate categories significantly greater risks seizure increase especially enzyme inhibiting valproate category risk ratio conclusion findings provide community based epidemiological survey evidence contraceptive methods may differ impact seizures impact may vary antiepileptic drug category published elsevier inc
today failure modes characterization early detection key issue complex assets due negative impact corrective operations conservative strategies usually put practice focused preventive maintenance paper anomaly detection issue addressed new monitoring sensor data characterizing modeling operational behaviors learning framework performed basis machine learning approach combines constrained means clustering outlier detection fuzzy modeling distances normality final score also calculated time considering membership degree resulting fuzzy sets local outlier factor proposed solution deployed cbm platform online monitoring assets order show validity approach experiments conducted real operational faults auxiliary marine diesel engine experimental results show fully comprehensive yet accurate prognostics approach improving detection capabilities knowledge management performance achieved quite high precision sensitivity specificity even given small percentage real faults present data elsevier rights reserved
preeclampsia presents serious risk maternal fetal morbidity mortality biomarkers detection preeclampsia critical risk assessment targeted intervention goal study screen potential biomarkers diagnosis preeclampsia illuminate pathogenesis preeclampsia development based differential expression network two groups subjects including healthy pregnant women subjects preeclampsia recruited study metabolic profiles subjects serum obtained liquid chromatography quadruple time flight mass spectrometry correlation metabolites analyzed bioinformatics technique results showed proline betaine proline potential sensitive specific biomarkers preeclampsia diagnosis prognosis perturbation corresponding biological pathways inos signaling nitric oxide signaling cardiovascular system mitochondrial dysfunction responsible pathogenesis preeclampsia study indicated metabolic profiling good clinical significance diagnosis preeclampsia well study pathogenesis elsevier inc rights reserved
purpose characterized progressive onset gait disturbances dementia urinary incontinence idiopathic normal pressure hydrocephalus inph considered rare diagnosed disease non invasive diagnostic markers still insufficient enable diagnosis inph certainty yet early treatment ventriculo peritoneal shunting reverse symptoms stop disease progression vascular circulation abnormalities inph may reflected changes subfoveal peripapillary choroidal thickness ppcht study uses spectral domain optical coherence tomography oct based measures retinal choroidal thickness test hypothesis assess ophthalmological non invasive markers inph methods twelve patients displayed neurological neuroradiological characteristics inph subject full ophthalmological examination including enhanced depth imaging edi oct included inph patients undergone shunting beneficial outcome parameters studied edi oct macular retinal thickness subfoveal choroidal thickness sfcht retinal nerve fiber layer thickness rnfl ppcht results compared healthy age matched controls results macular thickness rnfl values inph patients reflect atrophy non shunted inph patients showed significantly lowered median ppcht sfcht values compared healthy controls shunted inph patients displayed significantly higher median ppcht sfcht compared non shunted inph patients sfcht ppcht values shunted patients significantly different values healthy controls conclusion although limited small sample size oct measures study reveal significant changes choroidal thickness support hypothesis choroidal susceptibility hemodynamic alterations inph non shunted inph patients study show choroidal thinning combination normal rnfl values addition neurological neuroradiological exams pattern may aid challenging diagnosis inph
ability accurately forecast project final duration cost essential successful project management technique earned value management evm considered provide effective methodology obtaining forecasts however yet adequately tested empirical data therefore accuracy commonly used evm time cost forecasting methods evaluated diverse qualitative database consisting real life projects projects originate construction industry explicit focus construction projects provided moreover desired real forecasting outcomes based actual project progress data also supported monte carlo simulation study demonstrated highly accurate time cost forecasts obtained applying evm methodology furthermore best performing forecasting methods projects considered database identified also taking account timeliness influence project network structure american society civil engineers
objectives investigate association training related characteristics running related injury using new conceptual model running related injury generation focusing synergy training load previous injuries short term running experience body mass index design prospective cohort study month follow methods data two previous studies using methodology revisited recreational runners reported information running training characteristics weekly distance frequency speed sport participation injuries dedicated internet platform weekly volume dichotomized session frequency dichotomized main exposures considered necessary causes running related injury non training related characteristics included cox regression analyses effect measure modifiers hazard ratio measure association size effect measure modification calculated relative excess risk due interaction results one hundred sixty seven runners reported running related injury crude analyses revealed weekly volume hazard ratio confidence intervals weekly session frequency hazard ratio confidence intervals associated increased injury rate previous injury identified effect measure modifier weekly volume relative excess risk due interaction confidence intervals session frequency relative excess risk due interaction confidence intervals negative synergy found body mass index weekly volume relative excess risk due interaction confidence intervals conclusions effect runner training load rurining related injury influenced body mass index previous injury results show importance distinguish confounding effect measure modification running related injury research sports medicine australia published elsevier ltd
anxiety disorders headache among prevalent disorders among adolescents although cognitive behavioral therapy cbt proved efficacy disorders individually several barriers utilization including cost gaps knowledge treatment delivery modes utility comorbid disorders current study examined comparative efficacy week tcbt group treatment versus treatment usual group tau adolescents anxiety disorders headache north indian hospital based setting results adolescents suggested conditions improved significantly headache impact test children global assessment scale receiving tcbt showed significantly greater improvement tau condition participants receiving tcbt tau condition showed significant improvement state trait anxiety inventory study provides evidence supporting efficacy tcbt adolescents anxiety disorders headache group tcbt benefits easy dissemination increased access evidence based treatment thus lowering costs therapist time elsevier ltd rights reserved
several studies found children callous unemotional traits deficit processing emotionally negative material present study examined whether deficit also affects emotional memory twenty two children low traits children high traits years age selected community sample presented neutral negative emotional words using deeseroedigermcdermott paradigm true recall difference groups groups higher true recall rates neutral word lists negative lists however false recall although group differences neutral word lists high group recalled significantly fewer critical lures negative word lists low group furthermore high group significantly less false recall negative word lists compared neutral word lists low group showed difference false recall word lists results indicate children high traits deficiencies true memory performance yet less susceptible developing false memories concerning emotionally negative material
little known development olfactory organs camel study prenatal development neuronal differentiation vomeronasal organ vno olfactory epithelium one humped camel studied immunohistochemistry lectin histochemistry neuronal marker protein gene product pgp marker fully differentiated olfactory receptor cells olfactory marker protein intensely labeled olfactory receptor cells vno fetal ages indicating olfactory receptor cells differentiated fully matured vno fetuses pgp yielded faint immunoreactive signals vno although presence olfactory receptor cells demonstrated tissues intense wga lel stainings conclude camel vno bear differentiated still immature receptor cells addition onset neuronal differentiation seems somewhat earlier vno till half prenatal life microsc res tech wiley periodicals inc
paper proposes alternative option model dynamical power system process model based matrix polynomial form model obtained naturally writing high order differential equations components transmission line models modeled sequences rlc circuits power systems subsystems compose whole system another strategy would conversion known power system dynamical state space representation latter option adopted paper conversion process model another done carrying successive gaussian eliminations augmented frequency dependent matrix constructed state space model equivalence approaches evaluated compared accomplishing experiments two dynamical systems one composed rlc circuits calculated discretization process transmission lines frequency domain results considering computation transfer functions taking account methodologies demonstrate equivalence models
assess reach acceptability effect bsweetbabies video showing breast feeding skin skin care sucrose blood sampling intention recommend video advocate use interventions july video electronic survey produced posted year online viewer survey responses youtube analytics analyzed one year posting bsweetbabies video views countries viewers completed survey respondents aware analgesic effects breast feeding skin skin care sucrose nearly respondents found bsweetbabies video helpful resource answered would recommend video others viewing video respondents answered would advocate interventions bsweetbabies video showing effective pain treatment blood sampling large reach small response rate survey therefore analysis acceptability effect intention recommend video advocate interventions depicted limited research warranted explore best evaluate videos delivered social media determine effect video promote knowledge translation clinical practice
paper investigates operation hybrid power system novel fuzzy control scheme hybrid power system employs various autonomous generation systems like wind turbine solar photovoltaic diesel engine fuel cell aqua electrolyzer etc energy storage devices like battery flywheel ultra capacitor also present network novel fractional order fuzzy control scheme employed parameters tuned particle swarm optimization pso algorithm augmented two chaotic maps achieving improved performance fuzzy controller shows better performance classical pid integer order fuzzy pid controller linear nonlinear operating regimes fuzzy controller also shows stronger robustness properties system parameter variation rate constraint nonlinearity controller structures robustness highly desirable property scenario since many components hybrid power system may switched may run lower higher power output different time instants isa published elsevier ltd rights reserved
multidisciplinary research project series sought identify better understand multiple hygienic microbiological chemical contaminations point sources diffuse pollution contribute improvement surface water quality catchment area river swist germany municipal sewage treatment plants investigated followed event based investigation combined sewer overflows rainwater retention basins diffuse pollution surface subsurface run well drain pipes recently retention soil filters installed stormwater storage basins receiving surface waters order provide treatment combined sewer overflows investigated geographical information system analysis helped examine data temporal spatial dimensions model calculating microbial chemical loads within catchment area developed swistbox provides efficient tool risk assessment nearly two decades investigation demonstrated several elements landscape water balance account surface water pollution diffuse point sources depending land cover characteristics wastewater technology proportion wastewater compared total river water flow source vary importance catchment area findings applied sustainable health sensitive catchment management relation recreational agricultural water use well ecological aspects
work describes design development new drying system rollover carwash machine support numerical tools drying system composed pair stationary vertical dryers moveable horizontal dryer adjust contour vehicle definition dryers concept performance assessed individually check internal flow pattern improve airflow distribution issues expected provide feedback redesign geometric optimization dryers redesign dryers separately behaviour complete drying system studied actual vehicle models representative shortest tallest dimensions washed existing carwash machine sector drying efficiency whole system studied calculation shear stress distribution various surfaces given vehicle results allowed concluding overall drying performance design system good assure adequate drying vehicles surfaces results obtained numerical studies validated experimental measurements good agreement found two procedure employed work applied support design analysis mechanical drying systems society cad cam engineers publishing servies elsevier
vascular ehlers danlos syndrome veds rare severe connective tissue disorder caused mutations collagen type iii alpha chain cola gene describe pathogenetic heterozygous cola mutation glyasp identified using next generation sequencing year old italian female genetic test performed relatives present different clinical phenotypes confirmed carry mutation heterozygous state finding confirms mutations causing veds incomplete penetrance
paper propose computational fluid structure interaction fsi framework simulations interaction free surface flow floating structures offshore wind turbines framework based suitable combination finite element method fem isogeometric analysis iga good efficiency accuracy robustness characteristics free surface phenomena modeled using navier stokes equations incompressible two fluid flow conjunction level set method fem based moving domain ale vms technique employed discretize fluid mechanics equations iga based rotation free shell beam cable formulation employed model mechanics floating structures kinematic traction compatibility fluid structure interface handled means recently developed augmented lagrangian fsi formulation formal elimination lagrange multiplier variable quasi direct coupling strategy adopted handle large added mass implemented means matrix free technique mathematical formulation fsi problem algorithmic implementation described detail two numerical test cases presented first case free surface flow benchmark example solitary wave impacting fixed rigid platform second case set full scale free surface fsi simulations hywind floating wind turbine design subjected wave action computational results compared experimental simulation data good agreement achieved cases data available wind turbine computations regime high amplitude waves also presented elsevier ltd rights reserved
paper reports findings first western australian survey educators sexuality education aimed assess state relationships sexuality education rse state western australia key findings show secondary school teachers provided hours rse instruction national average however mainly taught curriculum topics abstinence intercourse married effects alcohol drug use decision making puberty sex ethics respectful relationships least taught subjects included sexually transmitted infections stis hiv aids birth control impact media sexual identity sexual orientation findings concern one considers nationally western australia higher rates stis among young people aged years teenage pregnancies parts country results survey used form baseline measure ahead roll australian curriculum includes rse focus area new western australian curriculum health physical education
surprisingly never empirical study creepiness international sample individuals responded online survey males perceived likely creepy females females likely associate sexual threat creepiness unusual nonverbal behavior characteristics associated unpredictability also predictors creepiness occupations hobbies results consistent hypothesis creeped evolved adaptive emotional response ambiguity presence threat enables maintain vigilance times uncertainty elsevier ltd rights reserved
groups typical operational amplifier irradiated cobalt unit group accumulating different total ionizing dose tid results showed tid caused power consumption current slew rate degenerate ultra linearity owing severe reduction current gain internal lpnp transistors pulsed ray irradiation experiments carried groups different values results revealed impact response pulsed ray irradiation greater devices absorbed tid mechanism explained basis circuit construction sensitive parameters circuit obtained via simulation spice simulation results additionally showed sensitive parameters optimized duration interruption caused pulsed ray irradiation would reduced significantly addition several proposals provided hardening devices
present optimal deterministic algorithms constructing shallow cuttings arrangement lines two dimensions planes three dimensions results improve deterministic polynomial time algorithm matouek comput geom optimal randomized algorithm ramos proceedings fifteenth annual symposium computational geometry socg leads efficient derandomization previous algorithms numerous well studied problems computational geometry including halfspace range reporting nearest neighbors search levels order voronoi diagrams linear programming violations dynamic convex hulls dynamic nearest neighbor search convex layers onion peeling nets halfspace ranges side product also describe optimal deterministic algorithm constructing standard non shallow cuttings two dimensions arguably simpler known optimal algorithms matouek discrete comput geom chazelle discrete comput geom
development pain common midlife resulting increased health care utilization costs aim study determine longitudinal trajectory overall bodily pain among women transition reproductive years menopause conducted analyses community based longitudinal cohort women enrolled study women health across nation one thousand four hundred ninety five women met inclusion criteria including defined date final menstrual period fmp complete data short form bodily pain primary exposure time fmp primary outcome rate change short form bodily pain measured scale severe pain performed within person trajectory analyses using piecewise regression following nonpara metric modeling functional forms mean bodily pain score time fmp mean bodily pain increased rate per year transmenopause interval spanning years fmp years fmp decreased rate per year depression sleep problems associated greater increases pain late reproductive years whereas abdominal cramps baseline predicted greater decreases pain late reproductive years perspective article shows bodily pain increases transmenopause diminishes postmenopause differences may reflect differences underlying mechanisms pain periods although mean changes small unlikely clinically meaningful magnitude change varied across subgroups women american pain society
fuzzy similarity powerful concept shown applied many areas paper shows another use fuzzy similarity function computation model based computing inner products parallel numeric computation briefly described fuzzy similarity also used symbolic computation
model attacks cyberphysical system game two players attacker system players may acquire complete information leads asymmetric information game furthermore players may certain fixed amount resources constrains strategies across time accordingly consider dynamic multiplayer nonzero sum game asymmetric information controllers total resource constraints certain assumptions information structure game devise algorithm computes subclass nash equilibria game also study denial service attack cyberphysical system model two player zero sum games apply algorithm compute saddle point equilibrium strategies attacker controller
problem national occupational injury prevention goals often prioritize reduction serious injuries study analyzed whether prioritization credible respect lost time injuries short long term work absence implications injury severity based versus injury absence based prevention approaches method data consisted national work site specific injury absence data construction workers denmark including workers copenhagen metro construction sites period results impact industry government absence length significantly dependent type injury sprains strains prevalent accounted approximately one third injuries absence fractures accounted one sixth injuries greatest proportion long term absence results give credibility need targeting sprains strains injury absence prevention initiatives national safety council elsevier ltd rights reserved
parent training effective intervention parents children variety childhood disorders including conduct problems parents often view behavioral parent training acceptable explanations rationales parent training commonly provided beginning treatment purpose study determine whether changing description behavioral parenting intervention influenced parents acceptability ratings whether mothers fathers differed ratings participants mother father dyads study participants viewed one two descriptions parent training focused either addressing deficits parenting skills enhancing existing parenting skills parents acceptability treatment descriptions evaluated using treatment evaluation inventory short form participants also completed eyberg child behavior inventory parental locus control scale multiple linear regression mixed factorial anova used analyze data significant interaction parent gender parent training description type also significant difference acceptability two parent training descriptions however mothers rated treatment descriptions acceptable fathers results indicated parental locus control significantly predicted acceptability parent training descriptions results current study suggested treatment acceptability influenced way interventions described future research focus increase acceptability parent training fathers parents external locus control
analysis existing air independent propulsion system solutions shows fuel cells potential achieve greatest energy efficiency silencing actions resulting direct conversion energy chemical reaction without moving parts paper describes research intended identify noise generated fuel cell demonstrator first phase work related silencing investigations main noise sources determined sound propagation sound insulation fuel cell enclosure performed accordance civilian military standardization guidelines
purpose specific aim study evaluate health sequelae preterm birth children years age compared age children born term selected variables include special health care needs chronic conditions caregiver perception health design methods secondary data analysis conducted evaluate health outcomes children years age born prematurely compared sample children born term national survey children health nsch nationally representative telephone interview survey parents caregivers children years age preterm birth determined parent report birth weeks early results utilizing children special health care needs cshcn screener children born prematurely compared children born term identified special health care need prevalent conditions groups year old children larger total sample children years age however children born prematurely described parents excellent good health conclusions premature birth places children increased risk conditions impede crucial activities childhood education psychosocial development play conditions may require medications increased health care services implications practice understanding relationship preterm birth ongoing health risks potential inform health care providers ability provide care maximizes potential children born prematurely health care providers need cognizant risk utilizing early screening encouraging intervention family supports elsevier inc rights reserved
investigate particular aspect ceo successor trustworthiness may critically important firm engaged financial misconduct specifically drawing prior research suggests facial appearance one critical way trustworthiness signaled argue leaders convey integrity component trustworthiness likely selected successors financial restatement predict appointments garner positive reactions external observers investment analysts media ceos perceived greater integrity archival study firms announced financial restatements find support predictions findings implications research ceo succession leadership selection facial appearance firm misconduct
paper presents model evaluation void ratio dependency water retention curve wrc deformable porous media models currently available literature purpose primarily empirical nature rely extensive laboratory testing parameter identification approach proposed requires additional parameters enables quantification dependency wrc void ratio solely based form wrc reference void ratio particular attention given effect hydraulic hysteresis evolution process aspect rarely addressed literature incremental expressions presented evolution main drying main wetting scanning curves due loading change hydraulic path scanning main wetting drying vice versa validity model demonstrated using experimental data range compacted reconstituted soils subjected various hydro mechanical paths good agreement obtained model predictions experimental data cases considered american society civil engineers
goal study determine effect acute transdermal oestradiol adipogenic potential subcutaneous adipose derived stem cells asc post menopausal women post menopausal women mean age years treated weeks randomized cross design transdermal placebo patches biopsies abdominal femoral fem subcutaneous adipose tissue sat obtained treatment mature adipocytes analysed cell size asc capacity proliferation growth rate differentiation triglyceride accumulation susceptibility tumour necrosis factor alpha induced apoptosis gene expression oestrogen receptors esr esr perilipin hormone sensitive lipase hsl also assessed fem sat sat weeks significantly increased asc differentiation whole sat hsl mrna expression compared placebo changes associated mrna expression oestrogen receptors hsl expression significantly increased fem sat transdermal treatment adipose derived stem cells proliferation apoptosis change either sat depot compared placebo short term appeared increase adipogenic potential fem sat post menopausal women possible implications metabolic disease future studies needed determine longer term impact regional sat accumulation context positive energy imbalance
animal experimental studies indicate acute chronic low dose ionizing radiation ldir msv low dose rate ionizing radiation ldrir msv exposures may harmful induces genetic epigenetic changes associated range physiological disturbances includes altered immune system abnormal brain development resultant cognitive impairment cataractogenesis abnormal embryonic development circulatory diseases weight gain premature menopause female animals tumorigenesis shortened lifespan paternal prenatal ldir ldrir exposure associated reduced fertility number live fetuses transgenerational genomic aberrations hand experimental studies ldir ldrir exposure also reported bring beneficial effects reduction tumorigenesis prolonged lifespan enhanced fertility differences reported effects ldir ldrir exposure dependent animal genetic background susceptibility age prenatal postnatal days sex nature radiation exposure acute fractionated chronic radiation exposure type radiation combination radiation toxic agents smoking pesticides chemical toxins animal experimental designs review paper aimed update radiation researchers radiologists current progress achieved understanding ldir ldrir induced bionegative biopositive effects reported various animal models roles played variety molecules implicated ldir ldrir induced health effects elaborated review help future investigations ldir ldrir induced health effects providing clues designing improved animal research models order clarify current controversial contradictory findings existing studies
background atopic dermatitis eczema chronic inflammatory disorder associated sleep disturbances quality life impairment sleep disturbances shown cause headaches childhood however association eczema headaches well established objectives sought determine whether childhood eczema associated increased headaches whether association related fatigue sleep disturbance methods analyzed data children adolescents population based cross sectional studies national survey children health national health interview survey results multivariate models controlling age sex race ethnicity household income highest level education family insurance coverage number persons household birthplace united states ever history asthma hay fever food allergy eczema found associated headaches studies pooled analysis studies children eczema compared without eczema significantly higher prevalence odds headaches mild severe eczema associated significantly higher odds headaches particular eczema associated atopy fatigue excessive daytime sleepiness insomnia nights sufficient sleep even higher odds headache eczema alone conclusions eczema associated increased headaches childhood particularly patients severe disease accompanied atopy fatigue sleep disturbances
advanced particle distribution controlling approach proposed laser melt injection process applies electric magnetic compound field assist laser melt injection process electric magnetic synergistic effect reinforcement particle distribution laser melt injection investigated using numerical experimental methods spherical particles used reinforcement distribution longitudinal sections laser melt injection layers examined sem studied computer graphics processing distributions fluid temperature fluid velocity reinforcement particles molten pool simulated using multi physics model coupled equations heat transfer fluid dynamics drag force lorentz force phase transition results show directional lorentz force due electric magnetic compound field sort volume force change equivalent buoyancy acting particles lorentz force gravity force direction majority particles trapped upper region laser melt injection layer lorentz force gravity force opposite direction particles concentrated bottom region result distribution gradient particles controlled electric magnetic compound field instead time consuming adjustment process parameters elsevier rights reserved
paper explore future smart environments given sense humor humor requires smartness entering witty remarks conversation requires understanding conversation conversational partner context history conversation try model interaction smartness use creating witty remarks also create humorous events smart sensors actuators embedded environments wearables allow make changes digitally enhanced physical environment witty remarks language counterpart witty events digital environments including social media environments communication characteristics sequential parallel juxtapositions incongruous contrasting events invade communication addition expected emerge created digitally enhanced physical environments accidentally intentionally
paper presents thermodynamic modelling simulation study small scale saturated solar organic rankine cycle orc consists stationary flat plate solar energy collector utilised vapour generator vane expander water cooled condenser pump simulations conducted constant condensing temperature pressure various cycle pressure ratios organic thermofluids including hydrocarbons hcs hydrofluorocarbons hfcs perfluorocarbons pfcs hydrofluoroethers hfes hydrofluoroalefins hfos special attention given influence fluids physical properties solar orc performance well fluids environmental safety impacts including global warming potential gwp flammability toxicity simulation results indicate fluid considered pressure ratio cycle leads various operating conditions collector evaporating pressure results various collector expander cycle efficiency instance increasing pressure ratio cycle enhances net work output thermal efficiency cycle whereas decreases flat plate collector efficiency results also indicate proposed system produces maximum net work output thermal efficiency using butene furthermore trans butene cis butene neopentane rea rfa hfc pfc rze hfo show promising solar orc thermal performances however flammability problem hcs global warming potential issue hfcs pfcs limit applications owing safety environmental concerns hand terms environmental impact thermofluids remcc refa hfes rze rzd hfos offer attractive alternative yet neither efficient generated highest amount net work output paper provides thermofluids selection guidelines achieve maximum efficiency within solar thermal energy technologies keeping environmental impacts considerations elsevier ltd rights reserved
several linear synchronous generators exploitation sea wave energy proposed machines require reactive power magnetization since use permanent magnets excitation use permanent magnets rough environment marine environment may weak point application kind devices order overcome difficulty authors paper propose linear synchronous electrical generator excitation uses ferrites suitable solutions extract energy sea waves paper describes analysis design improved axially magnetized tubular permanent magnet machine several innovative constructive solutions carried build low cost easy assemble robust machine ferrite tubular linear permanent magnet generator prototype made several simulation results shown illustrating system response various outputs including externally applied loads
applications process assessment established various domains require also safety considerations regarding processes products services often scope applied process assessment model inadequate meeting safety assurance requirements paper presents considerations assurance needs could met process assessment method including assessment process assessment model main domain interest nuclear power requirements used examples main result analysis assurance case systems software engineering process assessment method results used evidence safety assurance aim develop integrated approach manage assessment assurance related evidence efficient way
paper investigate power efficient resource allocation algorithm design secure multiuser wireless communication systems employing full duplex base station serving multiple half duplex downlink uplink users simultaneously propose multi objective optimization framework study two conflicting yet desirable design objectives total transmit power minimization total transmit power minimization end weighed tchebycheff method adopted formulate resource allocation algorithm design multi objective optimization problem moop considered moop takes account quality service requirements legitimate users guaranteeing secure transmission presence potential eavesdroppers thereby secure transmission enabled would possible imperfectness channel state information eavesdropping channels inter user interference channels incorporated robust resource allocation algorithm design although considered moop non convex solve optimally semidefinite programming relaxation simulation results unveil trade total transmit power total transmit power also confirm robustness proposed algorithm potential eavesdroppers
present paper provides dynamic non linear fully coupled finite element formulation based timoshenko beam theory study elasto thermoelectric responses thermoelectric devices two main motivations work study mechanical responses thermoelectric devices must taken account design peltier cells due fragility relative low strength semiconductors provide numerical tool decreases cpu time allow introduction designs based optimization processes sensitivity analyses could require many evaluations order undertake objectives work general three dimensional governing equations reduced one dimensional ones means several assumptions set five multi coupled partial differential equations obtained resultant expressions thermodynamically consistent form multi coupled monolithic formulation differently stagger formulations require two separated steps reach final result numerically set multi coupled equations discretized using method implemented feap taylor proper validation code four benchmarks performed using one dimensional dynamic analytical solutions developed authors finally formulation compared three dimensional formulation also developed authors rez aparicio model commercial peltier cell comparison reveals relative errors lower cpu times decrease significantly one order magnitude conclusion beam thermoelectric formulation accurate model reduces cpu time could used future design thermoelectric devices
ability recognize adequately interpret emotional states others plays fundamental role regulating social interaction body language presents essential element nonverbal communication often perceived prior mimic expression however neural networks underlie processing emotionally expressive body movement body posture poorly understood healthy subjects investigated using optically based imaging method functional near infrared spectroscopy fnirs performance newly developed emotion discrimination paradigm consisting faceless avatars expressing fearful angry sad happy neutral gait patterns participants instructed judge presented emotional state emotion task observed walking speed respective avatar speed task measured increases cortical oxygenated haemoglobin ohb response visual stimulation emotion discrimination ohb concentration changes enhanced negative emotions contrast neutral gait sequences right occipito temporal left temporal temporo parietal brain regions moreover fearful angry bodies elicited higher activation increases emotion task compared speed task haemodynamic responses correlated number behavioural measures whereby positive relationship emotion regulation strategy preference ohb concentration increases sad walks mediated ability accurately categorize sad walks results support idea distributed brain network involved recognition bodily emotion expression comprises visual association areas well body movement perception specific cortical regions also sensitive emotion network activated less emotion intentionally processed speed task furthermore activity perceptive network mediated ability correctly recognize emotions indirectly connected active emotion regulation processes conclude full understanding emotion perception neural substrate requires investigation dynamic representations means expression face elsevier inc rights reserved
purpose studies showed beneficial effect light therapy well work randomized crossover study aimed analyzing effects light exposition use luminette hospital department without access natural light materials methods study design proposed alternation two periods four weeks use luminette two periods four weeks without luminette every period participants completed questionnaires sociodemographic data seasonal general depression anxiety quality sleep slumber general health results twenty five persons participated study average age sample showed several benefits one month luminette diurnal slumber general health perception physical functioning pains role limitations due emotional problems one month later certain benefits remained without light therapy diurnal slumber pains emotional problems conclusion study showed use luminette could lead similar positive results obtained light therapy studies study confirmed luminette could positive effect well work societe francaise radiotherapie oncologique sfro published elsevier masson sas rights reserved
current control strategies livestock poultry facilities need improve interpretation thermal environment animals experiencing order provide optimum uniformly distributed throughout facility hence airspeed critical parameter influencing evaporative convective heat exchange must measured omnidirectional constant temperature thermal anemometer ambient dry bulb temperature tab compensation designed developed measuring airspeeds arduino measured two analog voltages determine thermistor temperature subsequently power dissipated near spherical overheated thermistor bridge circuit transistor operational amplifier custom wind tunnel featuring diameter pipe access insertion constructed calibrate different temperatures airspeeds constant relative humidity heat dissipation factor calculated given airspeed different ambient temperatures ranging degrees degrees used unique fourth order polynomial regression compensates temperature using fluid properties evaluated film temperature detailed uncertainty analysis performed key measurement inputs microcontroller analog digital converter thermistor regression statistics calibration standard propagated calibration regression absolute combined standard uncertainty associated temperature corrected airspeed measurements ranged relative relative system cost less usd components due simple hardware thermal anemometer well suited integration multi point data acquisition systems analyzing spatial temporal variability inside livestock poultry housing elsevier rights reserved
motivated need sequentially design experiments collection data batches blocks new pseudo marginal sequential monte carlo algorithm proposed random effects models likelihood analytic approximated new algorithm extension idealised sequential monte carlo algorithm propose unbiasedly approximate likelihood yield efficient exact approximate algorithm perform inference make decisions within bayesian sequential design propose four approaches unbiasedly approximate likelihood standard monte carlo integration randomised quasi monte carlo integration laplace importance sampling combination laplace importance sampling randomised quasi monte carlo four methods compared terms estimates likelihood weights selection optimal sequential designs important pharmacological study related treatment critically ill patients approaches considered approximate likelihood computationally expensive exploit parallel computational architectures ensure designs derived timely manner
verification ecdsa signature requires double scalar multiplication elliptic curve work study computation operation twisted edwards curve efficiently computable endomorphism allows reducing number point doublings approximately percent compared conventional implementation particular focus curve defined bit prime field develop several optimizations operation describe two hardware architectures computing operation first architecture small processor implemented cmos asic useful resource constrained devices internet things iot applications second architecture designed fast signature verifications using fpga acceleration used server side applications designs offer various trade offs optimizations performance resource requirements valuable iot applications
within solanaceae nolana sclerophylax miers two genera deserved special attention rare anatomical characteristics however poorly known cytogenetic perspective order discuss chromosome features evolutionary context classical staining chromomycin diamidino phenylindole cma dapi fluorescent banding situ hybridisation fish probes rdna loci applied root tips germinating seeds species presented chromosome number karyotypes highly symmetric chromosomes metacentric maximum three submetacentric pairs divaricata cma dapi banding technique assayed first time sclerophylax showed cma dapi bands associated nucleolar organiser regions nors first metacentric chromosome pair species fish technique applied four species sclerophylax first time one species nolana showed loci coincide cma dapi bands three sclerophylax species presented two pairs signals whereas adnatifolia showed three rdna loci resulted asyntenic sclerophylax localised chromosome divaricata despite morphological peculiarities nolana sclerophylax chromosome number karyotype features consistent position two genera within clade number position rdna loci established chromosome rearrangements suggesting different evolutionary pathways respect closest relatives lycium jaborosa
background prevalence clinical characteristics psoriatic arthritis psa patients psoriasis well described asian populations including koreans objective purpose study investigate prevalence psa using classification psoriatic arthritis caspar criteria basis physical examination well correlation psoriasis severity medical conditions including nail psoriasis methods single center cross sectional observational cohort study conducted included patients evaluated psa according caspar criteria psoriasis area severity index pasi nail psoriasis severity index napsi calculated results prevalence psa patients psoriasis korea performing logistic regression hyperlipidemia localized pustular psoriasis found significant predictors psa pasi score significantly higher psa patients psoriasis alone psoriatic nail involvement found study population psa patients nail psoriasis mean napsi score higher patients psa however difference statistically significant conclusion close relation psoriasis severity psa although nail psoriasis severity related psa status dermatologists diagnose psa current physical findings using caspar criteria validate caspar criteria psa diagnosis definition nail psoriasis clinical types severity caspar criteria reviewed
paper describes hysteresis aerodynamic properties discus near stalling angle wind tunnel tests carried full size woman discus experimental aerodynamic data obtained wind tunnel tests functions angle attack spin rate found drag lift pitching moment coefficients increase increasing angle attack stalling angle degrees beyond stalling angle decrease suddenly abruptly increasing angle attack hand recovery stall occur stalling angle degrees angle attack decreases stall state recovery actually occurs degrees alpha angle attack curve almost angle attack less degrees therefore hysteresis occurs near stalling angle authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
breast milks contaminated perfluoroalkyl substances pfass exposure pfass early stages life may lead adverse health effects among breastfed infants date perfluorootanoic acid pfoa perfluorooctane sulfonate pfos frequently measured pfass breast milks worldwide information shorter carbon chain pfass breast milk scarce study breast milks sampled korean lactating women measured seventeen pfass including ten perfluoroalkyl carboxylates pfcas four perfluoroalkyl sulfonates three perfluoroalkyl sulfonamides pfoa pfos detected breast milk samples median concentrations respectively perfluoropentanoic acid pfpea perfluorohexanoic acid pfhxa perfluoroheptanoic acid pfhpa detected higher frequencies ranging concentrations short carbon chain pfcas breast milk pfpea pfhxa highest ever reported date comparable pfos concentrations shorter chain pfca breast milk tended higher among women longer lactation period pfoa showed opposite trend suggesting possibility breastfeeding might important route excretion pfoa among lactating women fish consumption use consumer products skin care products cosmetics non stick coated cooking utensils identified significant predictors pfas concentrations breast milk health risks associated pfoa pfos exposure breastfeeding estimated negligible however risks short carbon chain pfcas could assessed lack relevant toxicological information efforts source identification exposure management measures shorter chain pfcas necessary elsevier inc rights reserved
myoclonus parkinson disease may related unrelated dopaminergic medication may share features cortical myoclonus aim study analyze clinical electrophysiological correlates dopaminergic treatment unrelated myoclonus patients included patients end dose myoclonus patients without myoclonus january june surface electromyography upper extremity muscles long latency reflexes llrs performed positive negative myoclonus duration observed rest tremor less frequent group myoclonus one patient myoclonus reflex mean llr amplitude significantly high myoclonus compared group without myoclonus dopaminergic treatment unrelated myoclonus less related rest tremor may positive negative exhibits similar features cortical myoclonus
new environmental laws restricted use hardwood trees overhead power lines structures poles cross arms leading companies seek alternative materials reforested wood coated polymeric resin proposed environmental friendly solution improved electrical properties protection external agents moisture ultra violet radiation fungi however single thin layer resin normally applied structures reveal inefficient due easily damage handling paper present composite coating based geotextile fibers polyurethane resin suitable wooden structures results obtained two different tree species managed reforested areas coated composite reveal additional layer provided stronger adhesion wood ccoating layer also improvement electrical properties better protection abrasion moisture
cinnamon many health improving compounds proanthocyanidins also potential prevention damages caused diabetes similarly alpha tocopherol natural antioxidant important role protection fatty acids membranes lipoproteins however addition antioxidants food may result interaction food matrix low stability unpleasant taste present study proanthocyanidin rich cinnamon extract prce cinnamomum zeylanicum encapsulated alpha tocopherol solid lipid microparticles slms spray chilling microparticles characterized regard physical chemical properties morphology proanthocyanidin stability release profile slms spherical average diameter proanthocyanidins highly stable slms stored days degrees moreover slms gradually released proanthocyanidins simulated gastrointestinal fluids diffusional process following korsmeyer peppas kinetic analyses antioxidant compounds indicated prce components exhibited higher scavenging capacity reactive oxygen species ros reactive nitrogen species rns thus slms produced present study potential application development new functional foods nutraceuticals also providing alternative controlled release proanthocyanidins alpha tocopherol intestine elsevier ltd rights reserved
purpose paper aim synthesise ultraviolet curable polyurethane acrylate based polyester polyol study change mechanical chemical optical weather resistance properties varying amount nanosilica also seeks determine optimum loading levels property maximisation design methodology approach new curable polyurethane acrylate synthesised using polyester polyol blend isophorone diisocyanate toluene diisocyanate hydroxyl ethyl acrylate resin incorporated nanosilica per cent basis total solids newly synthesised material characterised fourier transform infrared spectroscopy gel permeation chromatography ray diffraction scanning electron microscopy mechanical chemical optical properties coating films studied compared findings hardness tensile strength abrasion resistance show significant enhancement increasing amount nanosilica also found cured polyurethane acrylate nanocoating exhibited improved weather resistance optimum concentration nanosilica better performance found per cent total solids improvement result inherent nature nanosilica research limitations implications nanosilica used present context mean diameter near surface area nanosilica different particle size surface area surface modification used improve specific properties practical implications addition nanosilica particles polyurethane acrylate coating simple inexpensive method resulting phenomenal increase properties originality value new organic inorganic hybrid nanocoating improved weather resistance synthesised coatings could find applications demanding fields automotive topcoats
demonstrations link genetic variants criminal behavior stimulated increasing use genetic evidence reduce perceptions defendants responsibility criminal behavior mitigate punishment however limited data exist regarding impact evidence decision makers public large recruited representative sample adult population web based survey participants presented descriptions legal cases asked determine length incarceration convicted murderer adjudicate insanity defense decide whether defendant receive death penalty fully crossed participants factorial design used varying type evidence none genetic neuroimaging heinousness crime past criminal record sentence verdict primary outcome also assessed participants apprehension defendant belief free political ideology genetic knowledge across cases genetic evidence significant effects outcomes neuroimaging data showed inconsistent effect cases introduced contrast heinousness crime past criminal record strongly related participants decisions moreover participants beliefs controllability criminal behavior political orientations significantly associated choices findings suggest neither hopes genetic evidence modify judgments culpability punishment fears impact genetic evidence decision makers likely come fruition
line quality engineering important aspect regards manufacturing engineering process optimization target may achieved implementing robust engineering principles therefore present paper reflects results taguchi method approach applied fractioned factorial designed experiment case deep peck drilling twist drill composite material scope optimize surface state characterized roughness optically measured authors published elsevier
thirty years since vitro brainstem spinal cord preparation first presented method study automatic breathing behaviors neonatal rat straightforward preparation led incredible burst information location coordination several spontaneously active microcircuits form ventrolateral respiratory network brainstem despite advances knowledge mechanisms regulate central breathing behaviors still incomplete investigations nature spontaneous breathing rhythmicity almost exclusively focused mammals need comparative experimental models evaluate several unresolved issues different perspective mind sought develop new avian vitro model long term goal better understand questions associated ontogeny respiratory rhythm generation neuroplasticity whether multiple independent oscillators drive major phases breathing fact birds develop ovo provides unparalleled access central neuronal networks throughout prenatal period embryo hatchling free confounding interactions mother previous studies using vitro avian models strictly limited early embryonic period consequently details even presence brainstem derived breathing related rhythmogenesis birds never described present study used altricial zebra finch taeniopygia guttata show robust spontaneous motor outflow cranial motor nerve first detectable embryonic day four continues prenatal early postnatal development without interruption also show brainstem oscillations change dramatically course prenatal development sometimes within hours suggests rapid maturational modifications growth connectivity propose experimental preparation useful variety studies aimed testing biophysical synaptic properties neurons participate unique spatiotemporal patterns avian breathing behaviors especially context early development elsevier rights reserved
aimswe investigated risk cannabis use disorder cud among probands function parental psychopathology explored parent offspring gender concordance mechanism parental cud transmission offspring designfour waves data collection longitudinal epidemiological study psychopathology among regionally representative sample settingparticipants selected randomly western oregon usa initially assessed mid adolescence participantsthe reference sample included probands biological mothers fathers measurementscud episodes among probands assessed semistructured diagnostic interviews mid adolescence young adulthood life time psychiatric disorders among parents probands assessed probands approximately years age findingsthere increased risk cud onset among probands parental histories cud hazard ratio confidence interval hard drug use disorders antisocial personality disorder significant parent offspring gender concordance effect indicated females maternal cud history higher risk cud onset compared females without maternal cud maternal cud associated cud onset among males evidence parent offspring gender concordance effects paternal cud specific transmission conclusionsparental histories antisocial personality illicit substance use disorders associated increased risk cannabis use disorder onset offspring especially among females maternal cannabis use disorder histories
children show anger inappropriate situation based predominant incentives called context inappropriate anger children need attend interpret situational incentives appropriate emotional responses examined associations context inappropriate anger emotion recognition attention problems preschoolers male age months parents rated context inappropriate anger across situations teachers rated attention problems using child behavior checklist teacher report form emotion recognition ability recognize emotional faces using emotion matching test anger perception bias indicated anger non anger situations using adapted affect knowledge test children showed context inappropriate anger correlated lower emotion recognition higher attention problems higher attention problems correlated anger perception bias cross sectional correlational study provides preliminary findings children context inappropriate anger showed attention problems suggests problems tend covary associate deficits biases emotion knowledge
prove weak strong uniqueness results compressible navier stokes system degenerate viscosity coefficients vacuum one dimension words give conditions weak solution constructed jiu xin kinet relat models unique novelty consists dealing initial density rho contains vacuum use notion relative entropy developed recently germain feireisl mellet vasseur see germain math fluid mech feireisl novotny yongzhong indiana university mathematical journal mellet vasseur siam math anal combined new formulation compressible system haspot journal mathematical fluid mechanics hal hal arxiv haspot eprint arxiv hal precisely introduce new effective velocity makes system parabolic density hyperbolic velocity
investigated influential factors differences sexual risk taking among homosexual migrants data used paper based survey medical examination migrants sexual behaviors carried korea federation hiv aids prevention participants living south korea among migrants homosexuals times less likely use condom heterosexuals homosexuals times likely infected sexually transmitted diseases stds heterosexuals among homosexual migrants preferred risky sexual intercourse times less likely use condom heterosexual migrants fixed sexual partner times less likely infected hiv counterparts administrative programs stds prevention migrants focused sexual risk taking limited casual partnership unprotected sex previous contraction sexual diseases
waste heat recovery whr exhaust gas flow automotive engines proved useful path increase overall efficiency internal combustion engines ice recovery potentials shown several works literature however theoretical estimations present results prototypes fed steady flows generated auxiliary gas tank actual engine exhaust gases paper deals modeling experimental validation organic rankine cycle orc swash plate expander integrated turbocharged petrol engine using ethanol working fluid global simulation model orc developed maximum difference validated experimental results considering swash plate main limiting factor additional specific submodel implemented model physical phenomena element model allows simulating fluid dynamic behavior swash plate expander using model amesim differences tests model results found
paper aimed review applications potentials qeeg early diagnosis bipolar disorders well diagnostic efficacy differential diagnosis cognitive abnormalities clinical symptoms databases pubmed embase web sciences google scholar searched using search terms quantitative electroencephalogram qeeg bipolar disorders early diagnosis differential diagnosis selected evaluations evidence indicates diagnostic efficacy qeeg early diagnosis bipolar disorders bds controlled clinical studies indicated qeeg extracted measures may diagnostic value early differential diagnosis bds conventional assessments
since coal widely used next decades mainly developing countries china india carbon capture storage ccs technologies key role containment global warming paper presents techno economic comparison promising power generation technologies free power generation short term future particular three different power generation technologies considered conventional without ccs free configurations ultra supercritical usc pulverized coal combustion oxy coal combustion occ integrated gasification combined cycle igcc process simulation based aspen plus gate cycle commercial tools allows calculate plant performance including energy penalty due ccs system points usc points igcc parallel detailed economic assessment shows among commercial ready technologies usc could convenient solution power generation without ccs presenting levelized cost electricity lcoe sic significantly lower sic igcc whereas igcc becomes competitive free systems lcoe sic compared sic usc moreover oxy coal combustion currently mature enough commercial scale applications promises become strongly competitive ccs applications due relatively low levelized cost electricity sic kind analysis typically presents strong uncertainties due variability several key parameters fuel ccs prices determined fluctuation international markets improvement technologies therefore sensitivity analysis done determine effects potential fluctuation improvement economic performance plant elsevier ltd rights reserved
prevalence obesity increasing massively several decades industrialized countries obese women sexually active use fewer contraceptive methods high risk unintended pregnancy addition obesity important risk factor venous thromboembolism events arterial thrombosis myocardial infarction ischemic stroke data considered choosing contraceptive method obese women except depot medroxyprogesterone acetate injection progestin contraceptives progestin pills etonogestrel subdermal implant intra uterine devices preferred contraceptive methods obese women combined estrogen progestin contraceptives pill patch vaginal ring may proposed strict conditions associated vascular risk factor obesity increase risk failure contraceptive methods bariatric surgery complex situation requires program possible pregnancy contraception needed several months bariatric surgical techniques pass induce gastrointestinal malabsorption situation oral contraceptives recommended higher risk failure elsevier masson sas rights reserved
objective estimate prevalence unintended pregnancies relaxed assumptions regarding birth control use compared traditional constructed measure design cross sectional survey setting applicable patient nationally representative sample women aged years intervention none main outcome measure prevalence intended unintended pregnancies estimated traditional constructed measure national survey family growth nsfg constructed measure relaxing assumptions regarding birth control use reasons nonuse pregnancy timing result prevalence unintended pregnancies higher using traditional constructed measure compared approach relaxed assumptions nsfg confidence interval new construct using nsfg approach women stopped birth control become pregnant women using contraceptives time pregnancy reported mind getting pregnant classified intended pregnancies compared using new construct conclusion current measures pregnancy intention may overestimate rates unintended pregnancy pregnancies united states misclassified unintended using current approach corresponding estimated savings million public health care expenditures current constructs make assumptions may reflect contemporary reproductive practices improved measures needed american society reproductive medicine
glyceollins synthesized soybeans exposed biotic abiotic stress reported health benefits considering glyceollins novo synthesized daidzein via several enzymatic steps isoflavone concentration widely varies among soybean varieties abilities soybean cultivars synthesize glyceollins compared different elicitation conditions soybeans accumulated glyceollins differentially depending upon cultivar elicited aspergillus sojae contrary hypothesis high isoflavone varieties may accumulate glyceollins efficiently upon elicitation glyceollin accumulation response fungal elicitation related concentration either total isoflavones daidzein soybeans rather glyceollin levels significantly affected soybean cultivar effectively increased fungal infection data suggest selection strong fungal elicitor soybean cultivar genotype highly expresses genes involved glyceollin biosynthesis essential efficient glyceollin production
asch seminal research forming impressions personality widely cited providing evidence primacy warmth effect suggesting warmth related judgments stronger influence impressions personality competence related judgments fiske cuddy glick wojciszke effect fit asch gestalt view impression formation readily follow data presented original paper goal present study critically examine replicate studies asch paper relevant primacy warmth effect found evidence primacyof warmth effect instead role warmth highly context dependent competence least important shaping impressions warmth
paper maximal abelian dimension algorithmically computationally studied lie algebra nxn upper triangular matrices concretely define algorithm compute abelian subalgebras besides programming implementation symbolic computation package maple algorithm returns maximal abelian subalgebra hence maximal abelian dimension order matrices unique input needed obtain subalgebras finally computational study algorithm presented explain comment suggestions comments related works
present work presents teaching learning based optimization tlbo algorithm optimization technique area tuning classical controller installed automatic voltage regulator avr proposed tlbo algorithm applied aim find optimum value proportional integral derivative pid controller gains first order low pass filter installed avr voltage response avr system obtained using proposed tlbo based pid controller first order low pass filter compared offered algorithms reported recent state art literatures advantage using control strategy may noted providing good dynamic responses wide range system parametric variations line nominal operating conditions fast acting sugeno fuzzy logic technique applied obtain line dynamic responses studied model furthermore robustness analysis also carried check performance designed tlbo based pid controller analysis based voltage response profile investigated variations model parameters simulation results show proposed tlbo based pid controller significant optimization tool subject area avr system essence present work signifies proposed tlbo technique maybe successfully applied avr power system elsevier ltd rights reserved
job related hand dermatitis heads list reported occupational diseases called skin products understood mean protective creams skin cleansers skin care products used primary secondary prevention job related hand dermatitis interests evidence based medicine preventive measures occupational skin products used whose potential uses efficacy underpinned scientific research end arbeitsgemeinschaft fur berufs und umweltdermatologie working group occupational environmental dermatology abd ddg german dermatological society deutsche gesellschaft fur arbeits und umweltmedizin german society occupational environmental medicine dgaum summed latest scientific findings recommendations updated guideline benefit combined application protective creams skin care products primary secondary prevention work related contact dermatitis widely confirmed recent clinical epidemiological studies guideline clearly explains necessity demonstrating efficacy protective creams cleansing products means vivo methods sense repetitive applications transferable standardised testing systems designed examine irritation potential thus compatibility occupational skin cleansers reduction irritation protective skin creams developed validated multicentre studies skin protection creams cleansers status current assessment safety occupational skin products also summarised
wealth research past decades expanded understanding impact early life adversity physiological function consequently health wellbeing later life early life adversity increases risk developing number disorders chronic pain fibromyalgia irritable bowel syndrome although much research examined impact physical maltreatment increasing number studies published past years examining effect childhood psychological stress trauma development various types chronic pain conditions review clinical preclinical data examining link among early life psychological stress altered nociceptive behavior chronic pain later life evidence supporting role certain key neurobiological substrates including hypothalamic pituitary adrenal axis monoaminergic opioidergic endocannabinoid immune systems epigenetic mechanisms association early life psychological stress chronic pain provided greater understanding impact early life stress may inform development personalized treatments chronic pain later life strategies prevent onset susceptible individuals wiley periodicals inc
despite significant progress made study flame retardancy cellulosic building materials quest find ideal flame retardant material still continues review paper explores various options substitute halogenated flame retardants halogen free alternatives green building materials conventional flame retardants chemically react cellulosic building materials bamboo owing remain extraneous part substrate could easily leach due various factors leading low efficiency flame retardant action durability flame retardancy ensured applying additive would chemically react least one ingredients green building material flame retardant would remain inherent part substrate paper also describes reaction mechanisms various treatment methodologies ensuring efficacious actions non halogenated flame retardants green building materials wood bamboo
paper consider distributed setting computational mobile entities called robots perform tasks without global coordination depending environment well robots capabilities tasks might accomplished particular focus well known scenario robots reside nodes graph operate look compute move cycles one cycle robot perceives current configuration terms robots positions look decides whether move toward edge graph compute positive case performs instantaneous move along computed edge move compare two basic models first model robots fully synchronous second one robots asynchronous lights enhanced robot equipped constant number lights visible robots question whether one model powerful terms computable tasks considered das int conf distributed computing systems robots moving euclidean plane rather graph provide two different tasks show graphs one task solved fully synchronous model asynchronous lights enhanced model task converse holds hence assert fully synchronous model asynchronous lights enhanced model incomparable graphs opens challenging directions order understand peculiarities make models different
revisit equilibrium one dimensional phi model dynamical systems point view find infinite number periodic orbits computationally stable time orbits found exhibit positive lyapunov exponents periodic orbits confine every particle periodic chain trace either mirror image trajectory two dimensional phase space computationally stable sets pairs single particle orbits either symmetric antisymmetric last computational bit periodic chain odd numbered even numbered particles coordinates momenta either identical differ sign positive lyapunov exponents result infinitesimal perturbation breaking perfect two dimensional antisymmetry introduced motion expands four dimensional phase space extended space positive exponent results formulate standard initial condition investigation microcanonical chaotic number dependence model speculate uniqueness model chaotic sea connection collections deterministic time reversible states second law thermodynamics elsevier rights reserved
paper presents method estimating pulsating flow parameters partially open pipes pipelines internal combustion engine inlets exhaust pipes piston compressors procedure based method characteristics employs combination measurements simulations experimental test rig described enables pressure temperature mass flow rate measured within defined cross section second part paper discusses main assumptions simulation algorithm elaborated matlab simulink environment simulation results shown plots space time domain compared proposed models phenomena relating wave propagation boundary conditions acoustics fluid mechanics simulation results finally compared acoustic phenomena emphasis identification resonant frequencies
export coefficient model ecm widely used estimate nonpoint source nps pollution loads due ease application accurate pollution export coefficients crucial reducing uncertainties load estimation integrating artificial simulated rainfall experiments field survey data developed new method estimates regional pollution export coefficients results showed export coefficients calculated using new method accurately express regional rainfall runoff characteristics simulation precision method grown results traditional ecm export coefficients surveyed literature based calculated regional pollutant export coefficient annual loads plains area baiyangdian basin respectively among different types sources rural livestock greatest contribution whereas rural domestic waste represented smallest contribution approximately different sources pigs contributed almost half nps pollution livestock rural residential areas main land use pollution source rural living garbage main source rural domestic waste spatially nps mainly distributed zhulong juma watersheds watersheds contributed approximately nps per watershed however per area loads lower load watersheds larger nearly equal zhulong watershed therefore lower load watersheds addressed control nps pollution
purpose referrals specialist eating disorder services south asian community represented despite research suggesting disordered eating attitudes behaviours people similar population general purpose paper identify reasons sought inform ways encourage help seeking design methodology approach qualitative methodology used investigate barriers help seeking eds among community key informant focus group conducted clinicians working within local specialist service participants female male six focus groups conducted members community leicester participants female male recruited local university two charities children young people family centres findings number themes emerged possible factors delaying early access help lack knowledge eds potential seriousness ideals regarding body shape family living circumstances role food community participants acknowledged stigma among community associated mental health issues including eds concerns confidentiality approaching services particularly primary care originality value general practitioners specialist services need aware potential barriers help seeking eds early specialist help recommended effective treatment educational campaign around eds specifically designed community mind may improve awareness reduce stigma promote early help seeking
purpose aim study characterize age group differences driver risk inventory dri group driving influence dui offenders method data dui cases state nebraska used sample grouped age compared subscales dri results older adult dui finders accounted confidence interval dui cases older adult dui offenders demonstrated significantly greater alcohol risk scores younger age groups also significantly lower driver risk scores younger age groups implications results study demonstrate age related differences alcohol driving risk among dui offenders study provides starting point investigators clinicians address issue alcohol use driving older adults
diverticular disease small intestine rare especially located jejunum generally asymptomatic patients may complications acute diverticulitis peritonitis gastrointestinal bleeding obstruction cases recommended treatment surgery report year old patient ileal crohn disease long standing inflammatory phenotype developed acute diverticulitis jejunum presenting severe septic shock secondary multiple organ failure resolved medical treatment prolonged antibiotic therapy
post exposure prophylaxis pep biomedical approach hiv prevention administered potential exposure virus although originally approved occupational exposure hiv among healthcare workers pep remained controversial method preventing hiv infection following sexual exposure examine emerging social representations pep undertook qualitative thematic analysis articles published newspapers focused print media still reflect broader societal debates set agenda wider discussions media contribute shaping public perceptions policy priorities findings show two major social representations use pep hiv prevention amongst gay bisexual men positive social representation pep relatively straightforward solution pep metaphorically framed morning pill negative social representation pep posing risks yielding uncertain outcomes also found third social representation use pep amongst public health care workers pep represented needed deserved positive representation generally consisted anecdotal statements negative representation substantiated expert layperson voices rendering latter akin hegemonic representation pep generally found lack technical information newspapers information gap might inhibit informed discussion lead entrenching polarised social representations stigmatisation users pep
paper formation group multiple cooperative unmanned aerial vehicles uavs desired geometrical pattern tracking aerial target implemented using decentralized learning based model predictive control lbmpc lbmpc new control technique combines statistical learning along control engineering providing guarantees safety robustness convergence controller derived paper demonstrates ability vehicles cooperate decentralized manner solve formation problem presence system uncertainties proposed controller respects general formation constraints known reynolds rules flocking simulations main contribution paper lays use decentralized lbmpc solving problem formation group cooperative uavs tracking aerial target presence unmodeled dynamics theoretical proof stability support proposed controller
new grounded capacitor single resistance controlled sinusoidal oscillator srco explicit current output using two current conveyors ccs five passive elements presented proposed circuit offers independent control condition oscillation frequency oscillation low active passive sensitivities iii use grounded capacitors suitable implementation reasonably good frequency stability workability proposed configuration confirmed pspice simulations
increase number cores per processor complexity memory hierarchies make cache coherence key programmability current shared memory systems however ignoring detailed architectural characteristics harm performance significantly order assist performance centric programming propose methodology allow semi automatic performance tuning systematic translation algorithm analytic performance model cache line transfers design simple interface cache line aware optimization translation methodology full performance model exposes block based design caches middleware designers investigate two different architectures show applicability techniques methods many core accelerator intel xeon phi multi core processor numa configuration intel sandy bridge use mathematical optimization techniques tune synchronization algorithms microarchitectures identifying three techniques design optimize data transfers model single use single step broadcast private cache lines
paper investigate cognitive radio means communication utilized serve smart grid deployment end end home area network power generation show cognitive radio mapped integrate possible different communication networks within smart grid large scale deployment addition various applications smart grid defined discussed showing cognitive radio used fulfill communication requirements moreover information security issues pertained use cognitive radio smart grid environment different levels layers discussed mitigation techniques suggested finally well known role based access control rbac integrated cognitive radio part smart grid communication network protect unauthorized access customer data network large
electroencephalography eeg non invasive technique record brain activities natural settings ocular artifacts usually contaminates eeg signals removal critical accurate feature extraction classification increasing adoption wearable technologies single channel real time eeg systems often require real time signal processing immediate real time feedback becoming prevalent however traditional removal algorithms usually requiremultiple channels eeg data computationally expensive perform well real time article new hybrid algorithm proposed autonomously detects subsequently removes single channel steaming eeg data real time proposed single eeg channel algorithm also require additional reference electrooculography eog channel algorithm also implemented embedded hardware platform single channel wearable eeg system neuromonitor algorithm first detects zones using algebraic approach removes artifacts detected zones using discrete wavelet transform dwt decomposition method noising technique applied zone minimizes loss neural information outside zone qualitative quantitative performance evaluation carried epoch overlapping sliding window technique using time frequency analysis mean square coherence correlation coefficient statistics hybrid removal algorithm demonstrated real time operation latency psoc microcontroller based eeg system successful implementation removal single channel real time eeg data using proposed algorithm shows promise real time feedback applications wearable eeg devices
complementary alternative medicine cam widely used menopause although women disclose use healthcare providers narrative review aims expand providers understanding cross cultural approaches treating managing menopause providing overarching framework perspective cam treatments increased provider understanding awareness may improve provider patient communication also effectiveness treatments distinction illness patients suffer disease physicians treat highlights gap patients seek doctors provide may help clarify many women seek cam menopause example cam often sought women biomedicine unsuccessful inaccessible review relevance menopause three cam categories natural products mind body practices including meditation complementary health approaches including traditional chinese medicine tcm japanese kampo assessing effectiveness cam challenging individualized nature illness patterns associated treatments complicate design randomized controlled trials many women seek cam due inefficacy biomedical treatments cultural economic marginalization biomedical practitioners make effort learn cam ask patients cam use interest may dramatically improve patient provider relationship rapport well harnessing meaning response moerman imbued clinical encounter working women integrate cam related health seeking behaviors treatments providers may also boost efficacy biomedical treatments elsevier rights reserved
converters widely used switched mode power supplies high conversion efficiency flexible output voltage regulation problems converters variable load parametric condition lead development sliding mode controller paper adaptive non adaptive sliding mode controllers implemented control output voltage buck converter variable load conditions suitable sliding coefficient designed deriving state space representation buck converter modified adaptive loading conditions observed adaptive sliding mode controller output voltage remained constant step overload also reached desired value faster adaptive sliding mode controller also saved buck converter entering discontinuous mode step load condition
key area interest way early years educators perceptions concept gender may influence practice relation children ideas gender might supported reinforced however area received little attention highly gender segregated context pakistan understanding evidence based issues related gender pakistan thus crucial overcoming educational barriers article explored pakistani female pre primary teachers perceptions practices related gender early years interview observation data collected seven teachers one urban education school analysed thematically results indicated teachers perceptions reflect complex multifaceted dimensions gender within gradually shifting still traditional cultures pakistani society part female teachers views rooted dominant patriarchal ideologies example boys active assertive girls passive quiet however instances children academic performance play perceptions reflect attempts push gender boundaries challenge patriarchal ideologies teachers gender perceptions significant implications young children development understanding gender roles pakistan
trust reciprocity defined risky decision invest valued resources another party hope mutual benefit several fmri studies investigated neural correlates one shot multiround versions investment game however overall characterization underlying neural networks remains elusive coordinate based meta analysis employed activation likelihood estimation method articles investigate consistent brain activations stages trust reciprocity feedback stage results showed consistent activations anterior insula trust decisions one shot decisions reciprocate multiround likely related representations aversive feelings moreover decisions reciprocate also consistently engaged intraparietal sulcus probably involved evaluations reciprocity options contrary trust decisions multiround consistently activated ventral striatum likely associated reward prediction error signals finally dorsal striatum found consistently recruited feedback stage multiround likely related reinforcement learning conclusion results indicate different neural networks underlying trust reciprocity feedback learning findings suggest although decisions trust reciprocate may elicit aversive feelings likely evoked uncertainty decision outcomes pressing requirements social standards multiple interactions allow people build interpersonal trust cooperation via learning mechanism arguably learn distinguish trustworthy untrustworthy partners wiley periodicals inc
human life history characterized long development introduction new developmental stages childhood adolescence developing brain important role life history changes expensive tissue uses resting metabolic rate rmr newborn continues use almost first postnatal years hominid ancestors managed lift metabolic constraints increase brain size several interrelated ecological behavioral social adaptations dietary change invention cooking creation family bonded reproductive units life history changes opened new vistas developing brain became possible metabolically support transient patterns brain organization well developmental brain plasticity much longer period much greater number neurons connectivity combinations comparison apes included shaping cortical connections interaction infant social environment probably enhanced typically human evolution language cognition self awareness review propose transient subplate zone postnatal remnant interstitial neurons gyral white matter probably served main playground evolution developmental shifts describe various features makes human subplate uniquely positioned role comparison primates
paper provides new robust control synthesis method linear uncertain multivariable discrete time systems subject ellipsoidal parametric uncertainty type parametric uncertainty delivered classical prediction error identification methods full order model structure uncertainty represented linear fractional transformation fixed order infinity control design problems formulated terms solutions set dilated linear matrix inequalities control designs build quadratically parameter dependent lyapunov functions flexible structures auxiliary variables introduced improve performance reduce conservatism related fixed order controller synthesis employed structures may updated proposed iterative procedure numerical examples show effectiveness proposed method
smart grid delay sensitive requires techniques identify react abnormal changes system fault attacker shortcut etc timely manner paper propose real time detection scheme false data injection attack smart grid networks unlike classical detection test proposed algorithm able tackle unknown parameters low complexity process multiple measurements leading shorter decision time better detection accuracy objective detect adversary quickly possible satisfying certain detection error constraints markov chain based analytical model constructed systematically analyze proposed scheme analytical model able configure system parameters guaranteed performance terms false alarm rate average detection delay missed detection ratio detection delay constraint simulations conducted matpower package different ieee test systems
background despite prominent position methotrexate mtx rheumatoid arthiris therapeutics real world effectiveness may influenced relative lack tolerability side effects physicians may aware bothersome patients aim study identify suboptimal patient experience mtx raise awareness clinicians identify opportunities mitigate bothersome symptoms side effects optimize response mtx methods conducted prospective cross sectional online survey among patients members creakyjoints large arthritis patient community eligible participants must recently initiated new biologic subcutaneous mtx oral mtx last months uniquely assigned one groups descriptive statistics used compare patient reported side effects tolerability related mtx use medication groups mtx oral mtx biologic results total eligible patients completed survey grouped biologic mtx oral mtx demographics mean standard deviation age years white women symptoms significantly prevalent oral mtx groups included diarrhea fatigue malaise hair loss injection related pain lower mtx compared biologics total potential symptoms side effects examined higher dose mtx week associated greater likelihood side effects referent week conclusion results real world patient cohort suggest mtx accompanied many patient reported side effects tolerability problems may recognized physicians may impact treatment satisfaction medication adherence
background myxedema coma life threatening emergency presentation hypothyroidism however clinical features outcomes condition poorly defined rarity methods conducted retrospective observational study patients diagnosed myxedema coma july march using national inpatient database japan investigated characteristics comorbidities treatments hospital mortality patients myxedema coma results identified patients diagnosed myxedema coma approximately million inpatients database mean standard deviation age years two thirds patients female overall proportion hospital mortality among cases number patients highest winter season patients treated steroids catecholamines mechanical ventilation showed higher hospital mortality without variations type dosage thyroid hormone replacement associated hospital mortality common comorbidity cardiovascular diseases estimated incidence myxedema coma per million people per year japan multivariable logistic regression analysis revealed higher age use catecholamines without steroids significantly associated higher hospital mortality conclusions present study identified clinical characteristics outcomes patients myxedema coma using large scale database myxedema coma mortality independently associated age severe conditions requiring treatment catecholamines authors publishing services elsevier
objective identify genetic basis markedly reduced bone density multiple fractures adult patient hypophosphatemia hypercalciuria subjects year old vietnamese man unaffected two daughters wife methods performed biochemical studies sequenced slca gene using genomic dna peripheral blood mononuclear cells results biochemical evaluation proband revealed hypophosphatemia increased renal phosphate wasting hypercalciuria low serum parathyroid hormone fth elevated serum level mutation analysis slca gene revealed patient compound heterozygote two nonsynonymous nucleotide substitutions novel damaging mutation previously reported polymorphism consistent clinical diagnosis late onset hereditary hypophosphatemic rickets hypercalciuria hhrh wife older daughter carried polymorphism younger daughter compound heterozygous conclusions hhrh uncommon autosomal recessive disease generally manifests childhood rickets nephrolithiasis adult onset phenotype may occur heterozygous carriers slca mutations severe presentation proband adulthood marked nephrolithiasis multiple fractures low bone density emphasizes importance measuring serum phosphorus level patients suspected unexplained osteoporosis recurrent renal stones recognition late onset hhrh facilitates timely institution appropriate therapy elsevier inc rights reserved
suspensions microswimmers rich source fascinating new fluid mechanics recently predicted active pipe flow dispersion gyrotactic microalgae whose orientation biased gravity flow shear analytical theory predicts active swimmers disperse markedly distinct manner passive tracers taylor dispersion dispersing swimmers display non zero drift effective diffusivity non monotonic peclet number predictions agree numerical simulations hitherto tested experimentally facilitate comparison obtain new solutions axial dispersion theory accounting swimmer negative buoyancy local nonlinear response swimmers shear provided two alternative microscopic stochastic descriptions obtain new predictions suspensions model swimming alga durialiella valina whose motility buoyant mass parametrise using tracking video microscopy present new experimental method measure gyrotactic dispersion using fluorescently stained satina provide preliminary comparison predictions non zero drift mean flow microscopic stochastic description finally propose experiments full experimental characterisation gyrotactic dispersion measures discuss implications results algal dispersion industrial photobioreactors
sexual dysfunction associated psychotropic drugs threat patient quality life major reason non compliance psychotropic agents impair sexual response different ways due neurobiological mode action presentation frequencies sexual functional disorders selected psychopharmacological groups available treatment modalities literature search selection review relevant studies relevant groups impairments antidepressants antipsychotics due serotonin agonistic anti dopaminergic properties well prolactin increasing characteristics agents favorable side effects profile available phases sexual response affected treatment psychiatric disorders follow comprehensive treatment plan anticipates likely sexual dysfunction initiation treatment main aim improvement underlying primary disorder limited evidence based treatment strategies available
micrornas mirnas strongly implicated various cancers including prostate cancer recently microrna mir shown aberrantly expressed many tumor tissues functions tumorigenesis remain unknown study investigated role mir prostate cancer found mir markedly downregulated prostate cancer cell lines clinical tumor specimens gain function loss function studies showed mir promotes prostate cancer cell growth vitro vivo bioinformatics analysis luciferase reporter assays demonstrated mir directly targets suppresses eife rate limiting factor cap dependent translation plays important roles initiation progression prostate cancers studies demonstrated mir inhibits cap dependent translation proliferation prostate cancer cells targeting eife taken together findings suggest mir functions tumor suppressor directly targeting eife prostate carcinogenesis may used potential target therapeutic intervention prostate cancer
background coronary artery disease cad remains relative contraindication lung transplantation amenable effective palliation methods january july adults undergoing primary lung transplantation significant cad requiring prior concomitant revascularization propensity matching pre transplant patient characteristics identified well matched pairs possible matches cad unmatched patients compare postoperative morbidity graft function time related pulmonary function survival results compared cad patients cad intervention older likely male comorbidities likely idiopathic pulmonary fibrosis among propensity matched patients died hospital cad intervention group cad group intensive care unit stay days post operative stay days tracheostomy requirement patients primary graft dysfunction scores early longitudinal post transplant pulmonary function similar time related mortality years respectively unmatched cad patients fewer comorbidities lower mortality matched patients years respectively conclusions cad important risk factor lung transplant candidates influence minimized experienced centers effective palliation surprisingly however cad marker unfavorable patient phenotype worse typical post transplant survival irrespective whether cad present international society heart lung transplantation rights reserved
higher education sector operates increasingly complex global environment placing considerable stress resulting widespread change operating context leadership higher education institutions outcome increased likelihood conflict academics senior leaders presaging need engaged broader approach leadership based empirical research australian university sector paper contends distributed leadership approach appropriate higher education sector offers value supporting effective change acknowledging paradigm change needed implement approach successfully authors present process model underpin shift leader centric approach sustainable enabling evaluating reflective change process model presents synthesis systemic change higher education occur
background three dimensional printing numerous applications gained much interest medical world constantly improving quality printing applications contributed increased use patients paper summarizes literature surgical printing applications used patients focus reported clinical economic outcomes methods three major literature databases screened case series three cases described study trials surgical applications printing humans results surgical papers analyzed summarized using evidence table papers described use printing surgical guides anatomical models custom implants printing used multiple surgical domains orthopedics maxillofacial surgery cranial surgery spinal surgery general advantages printed parts said include reduced surgical time improved medical outcome decreased radiation exposure costs printing additional scans generally increase overall cost procedure conclusion printing well integrated surgical practice research applications vary anatomical models mainly intended surgical planning surgical guides implants research suggests several advantages printed applications research needed determine whether increased intervention costs balanced observable advantages new technology need formal cost effectiveness analysis
kriging interpolation provides best linear unbiased estimation unobserved locations heavy computation limits manageable problem size practice address issue efficient interpolation procedure incorporating fast fourier transform fft developed extending efficient approach propose fft based parallel algorithm accelerate regression kriging interpolation nvidia compute unified device architecture cuda enabled graphic processing unit gpu high performance cufft library cuda toolkit introduced execute computation intensive ffts gpu three time consuming processes redesigned kernel functions executed cuda cores modis land surface temperature day image tile resolution resampled create experimental datasets eight different output resolutions datasets used interpolation grids different sizes comparative experiment experimental results show speedup fft based regression kriging interpolation accelerated gpu exceed processing datasets large grid sizes compared traditional kriging interpolation running cpu results demonstrate combination fft methods gpu based parallel computing techniques greatly improves computational performance without loss precision society photo optical instrumentation engineers spie
background anti myelin oligodendrocyte glycoprotein mog antibodies detected various demyelinating diseases pediatric acute disseminated encephalomyelitis adem recurrent optic neuritis aquaporin antibody seronegative neuromyelitis optica spectrum disorder present patient developed anti mog antibody positive adem following infectious mononucleosis due epstein barr virus ebv infection case presentation year old healthy man developed paresthesia bilateral lower extremities urinary retention days onset due primary ebv infection mri revealed lesions cervical spinal cord conus medullaris internal capsule examination cerebrospinal fluid revealed pleocytosis cell based immunoassays revealed positivity anti mog antibody titer negativity anti aquaporin antibody symptoms quickly improved steroid pulse therapy followed oral betamethasone anti mog antibody titer month follow negative conclusions case suggests primary ebv infection would trigger anti mog antibody positive adem adult adem patients positive anti mog antibody titers correlate well neurological symptoms
waste materials generated building demolition become great challenge sustainable urban development due consumption limited landfill spaces water pollution energy consumption harmful gas emissions proper management demolition waste complex process requires systematic thinking analysis many methods proposed study environmental impact assessment demolition waste management dwm however found currently available studies pay little attention perspective complex adaptive system cas consider attitude interaction heterogeneous stakeholders well importance green dwm great influence effectiveness management aim research simulate explore change attitude dynamic interaction among heterogeneous stakeholders influence environmental performance dwm achieve aim model evaluating environmental impact dwm developed using agent based modeling abm approach main factors considered model ratio green deconstruction building deconstruction managers conventional demolition building destruction managers ratio green design managers design deconstruction conventional design managers interaction behavior heterogeneous stakeholders following herd theory model environmental impact assessment quantified four categories land resources water resources air resource energy resources proposed model demonstrated using data drawn chinese construction industry results reveal deconstruction method deconstruction oriented design widely adopted architects engineers negative environmental impacts generated reduced least furthermore results provide valuable information government departments make decisions improve environmental performance dwm elsevier ltd rights reserved
last years leading thinkers taken beyond mechanistic reductionist analysis systems theory critical boundary judgements fundamental systems analysis defining discussing boundary conditions also redefine values facts imposed hydrological economic analysis underpins decisions government policy water resources repeal legislation distributed interventions water efficient appliances rainwater harvesting previously enacted improve security regional water supply system examined case study results analysis defined costs benefits inside outside boundaries legitimate recognized consideration paper refers differences boundary conditions considers boundary conditions affect outcome analysis setting boundary conditions included excluded assumptions engineering economic analysis dominates outcomes decisions government policy insights general application development government water policy investigations outlined paper combined create enhanced version systems analysis policy setting targets water savings new dwellings established using appropriate boundary conditions target water savings feasible south east queensland seq provides cost benefit ratio results indicate policy mandating targets sustainable buildings would provide substantial benefits state queensland water utilities citizens
time giddy changes heading towards equality gender nevertheless profound struggle social power continues conflict birth control domain offspring aspects seriously taken account article explains recent tendency involving women democratic constitutional states choose become mothers assisted reproduction aim plan family without figure father importantly seek open fronts consider option monoparental new system parenthood family transformation means end beginning new age
asthma allergy share similar close course especially childhood considerable research effort put untangling associations however becoming obvious exceedingly difficult task fact research breakthrough perplexes picture steadily moving toward era personalized medicine begin appreciate thought single disease asthma fact accumulation distinct entities context syndrome characterized several yet poorly defined endotypes phenotypes question link asthma allergy probably becomes non relevant review revisit question putting emphasis multifaceted nature asthma
propagation analog single event transients asets multiple outputs bipolar junction transistor bjts integrated circuits ics reported first time results demonstrate asets appear several outputs bjt amplifier comparator result single ion single laser pulse strike single physical location chip large scale integrated bjt analog circuit independent interconnect cross talk charge sharing effects laser experiments together spice simulations analysis aset propagation domain used explain multiple output transients mots generated propagate device study demonstrates charge collection associated aset aset shape commonly used characterize propagation sets devices systems unable explain quantitatively mots propagate integrated analog circuit analysis methodology adopted involves combining fourier transform propagating signal current source transfer function domain approach reveals mechanisms involved transient signal propagation point generation one outputs without signal following continuous interconnect path
study intend develop optimal design method suspension bridge reliability analysis based minimization life cycle cost lcc reliability analysis performed considering aleatory uncertainties included result numerical analysis optimal design estimated based life cycle cost analysis depending result reliability analysis effect epistemic uncertainty safety index beta failure probability minimum life cycle cost random variables high level distributions generated critical percentile values obtained conservative bridge design sensitivity assessment
model hepatitis formulated study effects treatment public concern hcv transmission dynamics stability equilibria persistence model analyzed optimal control measure performed prevent spread hcv minimal infected individuals cost dynamical analysis reveals disease free equilibrium model asymptotically stable basic reproductive number less unity hand disease uniformly persistent numerical simulations conducted investigate influence different vital parameters corresponding optimality system optimal solution discussed pontryagin maximum principle comparisons model predicted consequences control presented elsevier rights reserved
broadly neutralizing antibodies associated spontaneous clearance hepatitis infection well viral persistence immune escape study neutralizing antibody epitopes needed unravel pathways resistance virus neutralization identify conserved regions vaccine design reported broadly neutralizing antibody bnab epitopes hcv envelope glycoprotein identified critical contact residues epitopes mapped onto linear sequence publicly available sequences downloaded contact residues within bnab epitopes assessed level conservation well frequency occurrence experimentally proven resistance mutations epitopes also compared two sequence datasets obtained fromsamples collected atwell defined time points acute days infections identify significant differences residue usage contact residues bnabswere containedwithin linear regions protein sequence analysis full length sequences frompublic databases showed experimentally proven resistance mutations present frequency comparison subtype viral sequences obtained samples collected acute chronic infection revealed significant differences positions changes residue position significant difference variability entropy majority experimentally described escape variants occur frequently nature observed differences acute chronically isolated sequences suggest constraints residue usage early infection elsevier rights reserved
contribution describes methodology computing compact time domain models electromagnetic devices containing lorentz materials finite element systems frequency domain procedure starts projection based model order reduction downsize system dimension resulting reduced order model transformed time domain leads state space representation proposed method mathematically proved preserve important system properties including passivity causality reciprocity allows reconstructing transient electromagnetic fields
glioblastoma multiforme gbm represents aggressive tumor type poor prognosis majority gbm patients cured high willingness among patients compassionate use non approved medications might occasionally lead profound toxicity year old patient glioblastoma multiforme gbm treated radiochemotherapy including temozolomide tmz surgery treatment outcome evaluated stable disease tendency slow tumor progression addition standard medication ondansetron valproic acid levetiracetam lorazepam clobazam patient took antimalarial drug artesunate art decoction chinese herbs coptis chinensis siegesbeckia orientalis artemisia scoparia dictamnus dasycarpus consequence clinical status deteriorated elevated liver enzymes noted peak values gpt alat got asat gamma respectively cessation art chinese herbs values returned back normal patient felt well literature hepatotoxicity well documented tmz rare art among chinese herbs used dictamnus dasycarpus reported induce liver injury additional medication included valproic acid levetiracetam also reported exert hepatotoxicity drugs alone may bear minor risk hepatotoxicity combination treatment might caused increased liver enzyme activities speculated combination drugs caused liver injury conclude compassionate use art chinese herbs recommended standard radiochemotherapy tmz gbm
magur clarias batrachus indigenous catfish commonly found india nepal bhutan bangladesh presently populations magur declined rapidly natural habitat mainly due overexploitation habitat degradation understanding population genetic structure species significance improvement stocks conservation species present study simple sequence repeat ssr markers used differentiate populations magur collected three geographic locations total ssrs mined novo assembled pooled whole genome sequence data batrachus bioinformatics pipeline stringent criteria applied analyze data resulted selection microsatellite loci falling intergenic region loci selected primer development loci successfully amplified loci found polymorphic species average observed well expected heterozygosity loci across different stocks varied respectively three populations segregated two clusters based genetic distance lucknow population formed one cluster bhubaneswar kolkata populations constituted another cluster comparable finding also deduced structure analyses results revealed significant variation among populations batrachus study
hypothalamic neuropeptide oxytocin forefront molecule among neuropeptides due pronounced prosocial effects potential use socioemotional deficits characterize prevalent neurodevelopmental psychiatric disorders autism spectrum disorders schizophrenia effects studied young adult subjects either animals humans complete lifespan trajectories system development activity far less investigated mini review primarily focus three temporal distinct periods lifeearly postnatal period puberty adolescence elderly selected neonatal period discuss role switch gaba action excitation inhibition first days birth rodents potential implications neurodevelopmental disorders puberty adolescence period consider particular relevance impact drug consumption stress aggression finally could potentially contribute maintain social capacities aged people ameliorate socially emotional deficits symptoms neurodegenerative diseases wiley periodicals inc develop neurobiol
objective joint united nations program hiv aids supported spectrum software package glastonbury connecticut usa used countries worldwide monitor hiv epidemic spectrum hiv incidence trends among adults aged years derived either fitting seroprevalence surveillance survey data generating curves consistent program vital registration data historical trends number newly diagnosed infections people living hiv aids related deaths article describes development application fit program data fpd tool joint united nations program hiv aids estimates round methods fpd tool hiv incidence trends described simple double logistic function function parameters estimated historical program data newly reported hiv cases people living hiv aids related deaths inputs adjusted proportions undiagnosed misclassified deaths maximum likelihood estimation minimum chi squared distance methods used identify best fitting curve asymptotic properties estimators fits used estimate uncertainty results fpd tool used fit incidence countries maximum likelihood minimum chi squared distance methods gave similar results double logistic curve adequately described observed trends four countries simple logistic curve performed better conclusion robust hiv related program vital registration data routinely available many middle income high income countries whereas hiv seroprevalence surveillance survey data may scarce countries fpd tool offers simpler improved approach estimating hiv incidence trends copyright wolters kluwer health inc rights reserved
environmental managers united states elsewhere increasingly perceiving dam removal critical tool river restoration enhancing watershed resilience new england dams dismantled ecological economic rationales surprising number removals including many ongoing generated heated conflicts restoration proponents local communities value dammed landscapes using comparative case study approach examine environmental conflict around efforts remove six dams new england removal efforts followed quite different paths resultant outcomes successful removal stalled removal failure despite seemingly favorable institutional conditions lengthy conflicts often transpired instances removals occurred successfully arbitrated paying attention local historical geographical conditions conducive removal brokering effective compromises dam owners various local actors stakeholders involved removal process yet results across cases suggest necessary sufficient conditions restoration dam removal since similar set conditions typified cases removals continuously stalled completely halted scholars examining intersection ecological restoration environmental politics remain vigilant seeking patterns generalities across cases environmental conflict order promote important biophysical goals must also remain open ways goals thwarted shaped conflicts deeply contingent historical geographical conditions broader institutional networks power influence
objective study estimates hospital costs treating work related injury among cohort sawmill workers british columbia methods hospital discharge records extracted cohort actively employed sawmill workers injury cases identified work related records using icd external cause injury codes indicate place occurrence responsibility payment schedule identifies workers compensation responsible payment hospitals british columbia standard ward rate chart prepared annually provincial ministry health bill collect payment agency like workers compensation agency costs calculated hospital perspective using billing chart costs expressed canadian dollars workers compensation claim records study population extracted matched hospitalised work related injury records costs also calculated work related hospitalisations hospital appear reimbursed workers compensation system results injuries requiring hospitalisation year follow period median stay hospitals days median hospital costs costly cause injury categories fire flame natural environmental struck median costs respectively least costly category cutting piercing median costs costly nature injury categories burns fracture lower limb median costs respectively least costly category dislocation sprains strains median costs total hospital costs work related injuries total hospital cost work related injuries provincial compensation agency apparently compensate conclusion prevention work related injuries save significant amount health care resources substantial costs remain uncompensated provincial compensation agency thus transferred provincial health care system annually elsevier ltd rights reserved
previous study developed machine learning procedure automatic identification classification spontaneous cord dorsum potentials cdps study supported proposal anesthetized cat spontaneous cdps recorded different lumbar spinal segments generated distributed network dorsal horn neurons structured non random patterns functional connectivity configurations changed non random stable configurations noceptive stimulation produced intradermic injection capsaicin anesthetized cat present study showing sequence identified forms spontaneous cdps follows markov chain least order one system memory sense spontaneous activation dorsal horn neuronal ensembles producing cdps independent recent activity used markovian property build procedure identify portions signals belonging specific functional state connectivity among neuronal networks involved generation cdps tested procedure acute nociceptive stimulation produced intradermic injection capsaicin intact well spinalized preparations altogether results indicate cdp sequences generated renewal stochastic process moreover possible describe functional features activity cord dorsum modeling cdp sequences generated markov order one stochastic process finally markov models make possible determine functional state produced cdp sequence proposed identification procedures appear useful analysis sequential behavior ongoing cdps recorded different spinal segments response variety experimental procedures including changes produced acute nociceptive stimulation envisaged useful tool examine alterations patterns functional connectivity dorsal horn neurons normal different pathological conditions issue potential clinical concern
propose integrated curriculum establish essential abilities computer programming freshmen physics department implementation graphical based interfaces scratch labview labview arduino curriculum computer assisted instrumentation design physics laboratories brings rigorous algorithm syntax protocols together imagination communication scientific applications experimental innovation effectiveness curriculum evaluated via statistical analysis questionnaires interview responses increase student numbers majoring physics performance competition results provide quantitative support curriculum remove huge barriers programming occur text based environments helped students gain knowledge programming instrumentation increased students confidence motivation learn physics computer languages
paper presents universal approach determination sensitivity functions dynamic neural networks application learning algorithms adaptive networks method based application signal flow graph specially defined graph adjoint method equally applied either feed forward recurrent network structures paper mainly concerned neural network applications approach different kinds dynamic neural networks considered discussed paper fir dynamic multilayer perceptron mlp cascade connection dynamic mlps well two non linear recurrent systems dynamic recurrent mlp network arma recurrent network rule sensitivity determination applied practical learning neural networks chosen results numerical experiments concerning application approach learning processes recurrent neural networks also given discussed copyright john wiley sons ltd
students find computer programming difficult subject frustrates affects performance paper present experience using arcs model improve students motivation learning computer programming different tactics used implement arcs four components attention relevance confidence satisfaction survey used determine effectiveness tactics students motivation also students performance compared peers performance last year found tactics make students highly motivated interested subject ultimately improves performance
world population continues grow water pollution presenting one biggest challenges worldwide wastewater generated demand clean water increasing ensure safety health humans environment highly efficient wastewater treatment systems reliable assessment water quality pollutants required advance holistic approaches water quality management increasing use ecological water treatment technologies constructed wetlands waste stabilisation ponds wsps challenge appropriateness commonly used water quality indicators instead additional indicators direct measures processes involved stabilisation human waste established provide depth understanding system performance study identified sterol composition wastewater treated wsps assessed suitability human sterol levels bioindicator treatment efficiency wastewater wsps treatment progressed wsps relative abundance human faecal sterols coprostanol epicoprostanol ethylcoprostanol sitostanol decreased significantly sterol composition wastewater changed significantly furthermore sterol levels found correlated commonly used wastewater quality indicators bod tss coli three seven sterol ratios previously used track sewage pollution environment detected faecal signal effluent wsps however others influenced high prevalence sterols originating algal fungal activities finding poses concern environmental assessment studies environmental pollution waste stabilisation ponds unnoticed conclusion faecal sterols ratios used reliable indicators treatment efficiency water quality wastewater treatment wsps complement use commonly used indicators water quality provide essential information overall performance ponds whether pond underperforming terms stabilising human waste holistic understanding essential aim improve performance treatment plant build new plants expand existing infrastructure future work aim establishing use sterols reliable water quality indicators broader scale across natural engineered systems elsevier ltd rights reserved
background deletion syndrome common microdeletion syndrome livebirths data regarding incidence populations limited also include ascertainment bias study designed determine incidence deletion miscarriage samples sent clinical molecular cytogenetic testing results twenty six thousand one hundred one fresh product conception poc samples sent cliacertified cap accredited laboratory april may molecular cytogenetic miscarriage testing using single nucleotide polymorphism snp based microarray platform retrospective review determined incidence deletion sample set fetal results obtained cases microdeletion region incidence cases found samples normal resolution traditional karyotyping chromosome abnormalities size three cases additional findings trisomy trisomy xxy ten cases deletion common similar deletion remaining cases deletions ranging size majority cases deletion maternally inherited chromosome significant relationship maternal age presence fetal deletion observed conclusions observed incidence deletion miscarriage samples higher reported general population prevalence research needed determine whether deletion causal factor miscarriage
sizing lined farm pond ofp various crop substitution ratios csr rainfed uplands eastern india addressed present study cross laminated polyethylene tarpaulin used lining ofp root zone water balance model used simulate water harvesting potential maize rice fields various csr ratio maize rice areas daily variations soil moisture storage crop root zone supplemental irrigation requirement critical growth stages water balance lined ofp using volume balance approach simulated years using soil crop meteorological data study area optimal size lined ofp csr found farm area meet requirement rice oryza sativa rainy season black gram vigna mungo mustard brassica campestris winter among inflow components lined ofp direct rainfall contribution major contributor surface runoff field year respectively among outflow components lined ofp demand crops found storage respectively optimal size lined ofp incur initial investment dollar indian rupees net profit benefit cost ratio internal rate return payback period years
ultra low power amp design presented paper proposed design enhancement technique used obtain sufficient gain bandwidth amp design transistors operated weak inversion region proposed amp designed using umcnm library simulated cadence analog design environment proposed circuit generates gain khz ugbw degrees phase margin upon simulation resultant power consumption
twenty first century vision toxicology involves transition away high dose animal studies vitro computational models nrc toxicity testing century vision strategy national academies press washington transition requires mapping pathways toxicity understanding vitro systems respond chemical perturbation uncovering transcription factors signaling networks responsible gene expression patterns essential defining pathways toxicity ultimately determining chemical modes action toxicant acts traditionally transcription factor identification achieved via chromatin immunoprecipitation studies summarized calculating transcription factors statistically associated downregulated genes lists commonly determined via statistical fold change cutoffs procedure sensitive statistical power may useful determining transcription factor associations move away arbitrary statistical fold change based cutoff developed context mapping human toxome project enrichment paradigm called information dependent enrichment analysis idea guide identification transcription factor network used test case activation mcf cells beta estradiol using new approach established time course transcriptional functional responses alpha beta associated short term transcriptional changes response sustained exposure led recruitment additional transcription factors alteration cell cycle machinery tfapc sox transcription factors highly correlated dose foxm involved cell proliferation enriched idea useful identifying candidate pathways toxicity idea outperforms gene set enrichment analysis gsea provides similar results weighted gene correlation network analysis platform helps identify genes annotated pathways
results environmental monitoring surface water quality lower volga basin given results regular observations differentiated water pollution assessed based criterion seasonal occurrence chemicals water gage sections classified zonal principle integrated estimate demonstrates considerable variations within year increase normal annual concentrations pollutants natural anthropogenic origin
developmental dyslexia highly heritable previous studies observed reduced cortical volume white matter integrity functional alterations left posterior brain regions individuals primary sulcal pattern hypothesized relate optimal organization connections cortical functional areas determined prenatal development may reflect early genetically influenced brain development characterize sulcal pattern using graph based pattern analysis investigate whether sulcal patterns parieto temporal occipito temporal regions atypical elementary school age children pre readers beginning readers preschoolers kindergarteners familial risk elementary school age children males females age range months preschoolers kindergarteners months pattern sulcal basin area left parieto temporal occipito temporal regions significantly atypical sulcal basins smaller size children correlated reduced reading performance single nonword reading measures significantly atypical sulcal area pattern also confirmed younger preschoolers kindergarteners familial risk results provide support atypical early brain development suggest may originate altered organization connections cortical areas left posterior regions
attention deficit hyperactivity disorder adhd highly prevalent among adults addictive disorders little known addiction patterns associated adhd diagnosis study examined addiction severity patients occurring addictive disorders adhd controlling potential influence associated psychiatric comorbidity data collected french outpatient addiction treatment centers total patients seeking treatment substance gambling addiction included treatment entry participants interviewed addiction severity index conners adult adhd diagnosis interview dsm caadid mini international neuropsychiatric interview mini structured clinical interview dsm axis borderline personality disorder scid history adhd associated earlier onset addiction poly dependence defined presence least two current substance dependence diagnoses addition tobacco dependence present borderline personality disorder persistence adhd adulthood associated higher prevalence poly dependence study highlights need early implementation preventive interventions substance use behavioral addiction children adolescents adhd need consider adhd treatment addictive disorders
research microstructure thickness interfacial transition zone itz concretes portland cement lightweight aggregates lwa studied established microstructure itz strongly depends nature aggregate specifically porosity water absorption study aims researching influence physical properties density porosity morphology lightweight aggregates pumice expanded clays microstructure thickness itz determine effect factors turn mechanical properties compressive strength lightweight concretes lwc lightweight aggregates characterized ray diffraction xrd scanning electron microscopy sem ray fluorescence xrf determine mineralogical morphological chemical characteristics characterization itz sem eds conventional optical microscopy carried specimens concrete manufactured lwa conventional aggregate order evaluate thickness furthermore determine porosity digital image processing dip performed lightweight aggregates contributed formation dense thinner itz compare itz conventional concrete lower porosity greater amount hydrated cement phases itz lightweight aggregates attributed physical morphological properties chemical mineralogical composition contributed decrease wall effect gestating surface formation achieving interlacing hydrated phases surface aggregates cementitious matrix elsevier ltd rights reserved
objectiveto evaluate microarchitectural changes condylar cartilage associated subchondral bone bisphosphonates treatment using ovariectomized ovx osteoporosis rat model methodsthirty six month old female sprague dawley rats randomly divided sham ovx risedronate ris treated groups ovx ris groups received bilateral ovariectomy ovx group treated subcutaneously saline whereas ris group received risedronate treatment subcutaneously months end months animals sacrificed entire condyles harvested micro histological analyses immunohistochemistry ihc performed assess expression type collagen protein semiquantitative imaging analysis resultsmicro analysis showed ovx group significant condylar subchondral bone loss compared sham shown significant decrease bone volume fraction trabecular thickness significant increase trabecular spacing ris group partial inhibition ovx induced bone loss detected staining showed proliferative layer condylar cartilage reduced hypertrophic chondrocyte layer increased significantly ris group compared sham ovx groups ihc showed reduced expression col ovx ris groups whereas expression col reduced ovx group increased ris group conclusionour findings suggest systemic bisphosphonate treatment influences structure ossification condylar cartilage dual action condyle postmenopausal osteoporosis rat model raises concerns potential side effects bps condyle elder patients
study proposed novel method extract endmembers hyperspectral image based discrete firefly algorithm dfa endmembers input many spectral unmixing algorithms hence paper endmember extraction hyperspectral image regarded combinational optimization problem get best spectral unmixing results solved discrete firefly algorithm two series experiments conducted synthetic hyperspectral datasets different snr aviris cuprite dataset respectively experimental results compared endmembers extracted four popular methods sequential maximum angle convex cone smacc findr vertex component analysis vca minimum volume constrained nonnegative matrix factorization mvc nmf effect parameters proposed method tested synthetic hyperspectral datasets aviris cuprite dataset recommended parameters setting proposed results study demonstrated proposed dfa method showed better performance existing popular methods moreover dfa robust different snr conditions international society photogrammetry remote sensing inc isprs published elsevier rights reserved
managers implementing change practitioners sometimes seen receivers change however practitioners often need actively create changes daily practices managers might familiar practices building information modelling bim important driver organizational change requires change bringing new technology use also practices collaboration different professions daily work practitioners create new practices reflective learning limited understanding practitioners actively involved change reflective learning implementing bim address limitation conducted qualitative case study primary data consist interviews analysed insights philosophy identified two methods reflective learning data deconstruction reconstruction deconstruction occurs new requirements practices based different ideas work asks practitioners change old ideas creating new practices reconstruction necessarily require changes basic ideas work changes seen improvements research contributes construction management literature linking reflective learning practitioners change caused bim
purpose aim study evaluate effect subjectrelated age sex systemic hypertension diabetes eyerelated refractive error optic disc size technology related signal strength index ssi scans determinants peripapillary macular vessel densities measured optical coherence tomography angiography octa normal eyes methods cross sectional study normal eyes subjects men women median age range underwent octa imaging linear mixed models used analyze effect determinants peripapillary macular vessel densities measured octa results found age optic disc size affect vessel densities regions associations face optic disc coefficient peripapillary vessel densities higher female individuals face disc coefficient peripapillary vessel densities lower whereas parafoveal vessel density higher coefficient subjects hypertension vessel densities lower subjects diabetes ssi showed statistically significant association vessel densities regions coefficients peripapillary macular sectors conclusions peripapillary vessel densities higher female subjects hypertension diabetes also affected vessel densities vessel densities regions significantly higher scans higher ssi results considered interpreting vessel densities retinal diseases glaucoma
purpose background aim study evaluate effects quetiapine lithium actigraphy measured circadian parameters patients bipolar depression methods procedures week open label prospective randomized comparative study assessments included item hamilton depression rating scale score actigraphic measures concerning previous days collected visit weeks baseline actigraphic data analyzed cosinor analysis findings results medication time interaction medication time significantly associated acrophase entire group respectively specifically acrophase significantly delayed weeks respectively quetiapine group statistics significantly increased time entire group significant increase statistics weeks quetiapine group respectively weeks lithium group respectively addition scores item hamilton depression rating scale significantly associated statistics weeks entire group implications conclusions quetiapine lithium affected several circadian parameters including peak activity time robustness circadian rhythm exerted different effects acrophase patients bipolar depression particular clinical depressive symptoms associated robustness circadian rhythm course week treatment
lcl filters widely used grid connected inverters however problem time delay affects stability digitally controlled grid connected inverters lcl filters fully studied paper systematic study carried relationship time delay stability single loop controlled grid connected inverters employ inverter current feedback icf grid current feedback gcf ranges time delay system stability analyzed deduced continuous domain discrete domain shown optimal range existence time delay weakens stability icf loop whereas proper time delay required gcf loop present work explains first time different conclusions stability icf loop gcf loop drawn previous studies improve system stability linear predictor based time delay reduction method proposed icf time delay addition method used gcf controller design method presented guarantees adequate stability margins delay dependent stability study verified simulation experiment
weeds sugar beet farming reduce crop yield quality also lead higher labor material losses recent years order eliminate reduce damage caused weeds sugar beet farming weed control gained importance end various studies conducted robotic weed control detecting weeds using image processing algorithms hoeing spraying weeds study weeds sugar beet fields detected image processing algorithm sprayed liquid height spraying nozzle ground measurements spraying robot carried different speeds weed surface covering area spraying liquid evaluated two different methods decrease nozzle height smart spraying robot caused decrease different weeds surface covering area spraying liquid decrease weed surface covering area pixels spraying liquid
main objective study development correlation model dynamic bayesian belief networks dbbns followed inverse economic analysis based quadratic hierarchical bayesian inference prediction method using markov chain monte carlo simulations developed model implemented predict future degradation maintenance budget suspension bridge system bayesian inference applied find posterior probability density function source parameters damage indices serviceability given years maintenance data simulated risk prediction decreased serviceability conditions gives posterior distributions based prior distribution likelihood data updated annual maintenance tasks compared conventional linear prediction model proposed quadratic model provides highly improved convergence closeness measured data finally developed inverse dbbn analysis method allows forecasts future performance financial management complex infrastructures providing sensitivity serviceability risky factors maintenance budgets structural components overall system
recent years lot research done electric hybrid vehicles including internal combustion engine fuel cell main aim studies design electric system capable feeding electric motor giving similar performance internal combustion engine vehicle icev first step substituting icev hvs since final user accept downgrade nowadays cars bring kind services make vehicle comfortable air conditioning one modern vehicles must prepared include air conditioning system acs even smallest sizes therefore acs effects energy management must taken account design power consumption acs depends directly thermal load vehicle cabin latent sensible ambient conditions converter efficiency compressor car power system car main objective research analyze behavior fuel cell car different driving cycles ambient conditions passenger load fuel consumption data taken performing cycles increment hydrogen consumption found acs switched copyright hydrogen energy publications llc published elsevier ltd rights reserved
recent years energy consumption decentralised feed storage renewable energies power system complexity grown rapidly worldwide hence electrical networks already working stability limits originally designed today load consequently risk power system instability greatly increased therefore protecting electrical networks critical situations blackouts become relevant issue network operation fast evaluation current network state particularly dynamic state use appropriate remedial measures control rooms play important role solving problem paper describes online dynamic security assessment system prevention power system instabilities improvement electrical network state applying remedial measures
deformations applied body tissues daily activities result morbid conditions various medical treatments affect cell viability biological function mechanobiological phenomena often studied vitro monolayer cultures facilitate studies cost effectively developed novel printable cell stretching apparatus apparatus used apply tensile strains cells cultured elastic stretchable substrata either sustained dynamic cyclic application apparatus parts three dimensionally printed excluding motors stretching automatically performed two direct current geared motors controlled programmable microcontroller platform demonstrate functionality novel printable device produced multiple copies research labs cost per unit including motors controller performed cell culture studies monitored fluorescence microscopy specifically applied sustained cyclic radial stretching large strains niht mouse fibroblasts demonstrated cell viability adhesion morphology maintained following stretching apparatus designed low cost rapidly manufactured university small company setting simple use control flexible versatile design allows users experimentally induce different stretching regimes varying amplitudes frequencies elsevier ltd rights reserved
legislation fiscal policies remained key drivers construction waste minimization often suggested reducing waste landfill require improvement existing waste management policies fiscal framework need adequate inputs construction professionals means engendering effective waste management policies study explores industry practitioners viewpoints effective policies minimising waste landfilled construction industry using exploratory sequential mixed method approach qualitative quantitative methods used first phase study data collected focus group discussions experts construction industry findings qualitative study served input questionnaire used elicit wider opinion experts quantitative stage study study suggests waste management legislation policies effectively drive construction waste minimization six key measures important include provision tax breaks incentives good waste performers waste management businesses increased targeting design stages policies iii extension sustainable design appraisal systems allocating points proven waste performance measures increased stringency legislative measures requiring use proven waste efficient design procurement construction methods increased stringency fiscal policies increasing penalties poor waste performance corroboration policy requirements enablers facilitators strategies legislative fiscal measures could tailored enhanced discussed paper embracing stringent palliative policy measures suggested study substantial construction waste could diverted landfill elsevier ltd rights reserved
present sam software package dynamically adaptive parallel solution partial differential equations triangular grids created via newest vertex bisection element order imposed sierpinski space filling curve provides algorithm grid generation refinement traversal inherently memory efficient based purely stack stream data structures completely avoids random memory access using element oriented data view suitable local operators concrete simulation scenarios implemented based control loops event hooks hide complexity underlying traversal scheme two case studies presented two phase flow heterogeneous porous media tsunami wave propagation demonstrated tohoku tsunami japan sam features hybrid mpi openmp parallelization based sierpinski order induced elements sections defined contiguous grid cells define atomic tasks openmp work sharing stealing well migration grid cells mpi processes using optimized communication load balancing algorithms sam achieves strong scaling efficiency cores efficiency weak scaling test cores billion elements tests including adaptive mesh refinement load balancing time step
prevalence hcv infection higher among prisoners general population introduction hcv direct acting antivirals daa holds potential improve clinical outcomes also inmates however treatment hepatitis inmates face several clinical logistical issues peculiar prison environment recommendations management hcv infection specific penitentiary setting daa era remain scant italian society penitentiary medicine healthcare therefore issued recommendations provide clinicians guide comprehensive management hcv infection restriction setting taking account peculiar characteristics dedicated diagnostic treatment procedures established prison particular use daas appears crucial provide patients effective therapeutic option able overcome limitations ifn based regimens short period treatment daa treatment initiated soon possible eligible subjects aim cure patient well limit transmission hcv infection inside penitentiary system free community inmates ends release importantly efforts made open discussion regulatory bodies define specific regulations aimed guarantee wide access effective therapies eligible patients optimize management adherence hcv treatment ensure therapeutic continuity discharge prison
paper presents adaptive building skin system attempts establish foundations intuitive responsive interface interior exterior spaces respect environmental thermal acoustic user comfort considerations enabling components act individual context aware sensor actuator nodes capable differentiated yet correlated actions reactions interactions proposal situates system within intelligent environment whose ecosystem operational scope subsumes yet extends beyond interior environments include exterior domains via wearable devices accordingly sensed data device accessible across devices topology meshed nodes computationally processed behavior node potentially informed informing status individual sets nodes manner building skin construed mere envelope rather system comprised agents conjunction embedded ambulant wearable agents actively promote well comfort spatial experience users
introduction approved biologic therapies effective treatment psoriasis limitations tildrakizumab different mechanism action humanized immunoglobulin binds subunit areas covered phase iii clinical trials investigated pharmacokinetics efficacy safety immunogenicity tildrakizumab patients psoriasis mean half life tildrakizumab days tildrakizumab achieved pasi week doses respectively phase iib randomised clinical trial rct pasi week respectively two phase iii rcts frequently associated adverse events include headache upper respiratory tract infection expert opinion recent standards tildrakizumab relatively modest efficacy possibly due less intensive dosing regimen head head rcts comparison current therapies ustekinumab secukinumab respectively needed understand relative efficacy addition trials patients failed multiple biologics patients psoriatic arthritis would helpful low frequency injections tildrakizumab maintenance regimen may encourage adherence aid persistence
study examines normal aging affects occurrence different types incorrect responses visual short term memory vstm object recall task seventeen young mean years normally aging older mean years adults participated memory stimuli comprised two four real world objects memory load presented sequentially random locations computer screen retention interval test display presented comprising empty box one previously presented two four memory stimulus locations participants asked report name object presented cued location errors rates wherein participants reported names objects presented memory display cued location non target errors objects presented memory display non memory errors compared significant effects aging memory load target recency error type absolute error rates found non target error rate higher non memory error rate age groups indicating vstm may often populated partial traces previously presented items high memory load non memory error rate higher young participants compared older participants memory target presented earliest temporal position however non target error rates exhibited reversed trend greater error rates found older participants memory target presented two recent temporal positions data interpreted terms proactive interference earlier examined non target items interfering recent items false memories non memory items categorical relationship presented items interfering memory targets slot flexible resource models spatial coding deficits
article concerns problem detecting masqueraders computer systems masquerader computer system intruder pretends legitimate user order gain access protected resources article presents intrusion detection method based fuzzy approach two types user activity profiles proposed along corresponding data structures solution analyzes activity computer user relatively short period time building user profile profile based recent activity user therefore named local profile analysis involves creating general structure based defined number local profiles one user called fuzzy profile represents generalized behavior computer system user fuzzy profiles used directly detect abnormalities users behavior thus possible intrusions proposed solution prepared able create user profiles based countable features derived user actions computer system used commands mouse keyboard data requested network resources presented method tested using one commonly available standard intrusion data sets containing command names executed users unix system therefore obtained results compared approaches results experiments shown method presented article comparable best intrusion detection methods tested data set matter obtained results proposed solution characterized low computational complexity confirmed experimental results
main aim present recent developments applications symbolic computing probabilistic stochastic analysis done using example well known maple system key theoretical methods discussed analytical derivations classical monte carlo simulation approach iii stochastic perturbation technique well semi analytical approaches demonstrated particular engage basic symbolic tools implemented system derive basic equations stochastic perturbation technique make efficient implementation semi analytical methods using automatic differentiation integration provided computer algebra program second important illustration probabilistic extension finite element finite difference methods coded maple showing solve boundary value problems random parameters environment symbolic computing response function method belongs third group interference classical deterministic software non linear fitting numerical techniques available various symbolic environments displayed recover context probabilistic structural response engineering systems show solve partial differential equations including gaussian randomness coefficients
much evidence exists concerning effects sleep mood transcranial bright light study students wake time later weekends free days participated double blind placebo controlled experiment comparing effects bright light placebo data collection consisted sleep assessment sleep diaries actigraphy addition fatigue severity scale profile mood states poms administered following week baseline recording therapy initiated aiming phase advance sleep wake period therapy lasted weeks consisted gradually advancing daily light exposure min transcranial bright light subjects two conditions change differently baseline post treatment sleep parameters significant condition time interaction found one six subscales vigor activity poms suggesting favorable development baseline post treatment placebo compared bright light condition differences terms side effects reported conditions concluded transcranial bright light times conventional light therapy phase advancing properties influence sleep parameters differently placebo transcranial bright light associated less favorable development baseline post treatment one mood parameter compared placebo
exciting paradise data emerging daily life along development relative perceptive technologies smart home automatically actively recognize real time activities big data one key challenge future pervasive computing ambient intelligence solving problem greatly enhance development relative technologies eldercare childcare healthcare paper proposes event driven approach namely activity event model real time activity recognition smart home erar erar approach segments data flow based aes dynamic segmentation algorithm recognizes activities based svm model aes dynamic segmentation algorithm uses activity event similarity aes dynamically segment data flow effectively distinguish concurrent activities experiments context smart home presented show erar approach performs better baseline approaches
paper concerned traveling wave solutions analytical treatment infiltration equation based new technique namely tan phi expansion method solution procedure nonlinear infiltration equation investigated obtained exact solutions aforementioned nonlinear infiltration equation solutions contain four types hyperbolic function trigonometric function exponential rational solutions recently method developed searching exact traveling wave solutions nonlinear partial differential equations shown method help symbolic computation provides straightforward powerful mathematical tool solving nonlinear partial differential equations
system compensator designed cancel mechanical characteristics power electronics controlled induction motor drive coupled electrical generator system emulation scheme using compensator enables accurate emulation high speed high power mechanical system dynamics compensator developed based system transient response test rig considering full operating range test system design process compensator described validated time frequency domains finally effectiveness compensator demonstrated simulation experimental emulation aero gas engine dynamics
paper presents novel scheme automatic generation control agc interconnected two area multi source power generation deregulated environment conventional two area agc system modified take account effect bilateral contracts dynamics considered two area power system area contains two gencos first genco reheat steam turbine appropriate generation rate constraint nonlinearity second genco gas turbine generation performances integral proportional integral integral derivative proportional integral derivative pid evaluated proposed agc system deregulated environment gain controllers speed regulation parameters optimised using differential evolution algorithm differential evolution algorithm used convergence superiority easy implement performance algorithm applied proposed problem compared genetic algorithm establish optimisation superiority former elsevier ltd rights reserved
androgen deprivation therapy adt frequently used treatment advanced prostate cancer adt associated numerous side effects related mode action namely suppression testosterone castrate levels recently several large retrospective studies also reported increased risk diabetes cardiovascular disease men receiving adt although risks confirmed prospective randomized trials review literature consider risk cardiovascular disease different forms adt examine detail potential mechanisms risk could mediated mechanisms discussed include metabolic syndrome resulting low testosterone level potential roles testosterone flare gonadotropin releasing hormone receptors outside pituitary gland altered levels follicle stimulating hormone finally clinical implications men prescribed adt treatment advanced prostate cancer considered elsevier inc rights reserved
silicon nanowire field effect transistor sinw pet device interfaced cells however application noninvasive real time monitoring interfacial effects cell growth differentiation sinw fully explored cultured rat adrenal pheochromocytoma cells type neural progenitor cell directly sinw pet devices monitor cell adhesion growth morphological changes neuronal differentiation period monitoring performed measuring non faradaic electrical impedance cell sinw pet system using precision lcr meter sinw pet devices exhibited changes impedance parameters cell growth differentiation negatively charged cell membrane seal resistance membrane capacitance cell sinw interface observed cell growth neuronal differentiation impedance magnitude increased phase shifted negative values however impedance changes cell growth already plateaued seeding impedance changes continued last observation day differentiation results also indicate frequency shift khz growth factor induction resulted larger coverage cell membrane sinws due distinctive morphological changes according vinculin staining encapsulation cells hydrogel scaffold resulted lack trend impedance parameters confirmed impedance changes due cells moreover cytolysis differentiated cells led significant changes impedance parameters equivalent electrical circuits used analyze changes impedance values cell growth differentiation technique employed study provide platform performing investigations growth factor induced progenitor cell differentiation
advanced glycation end products ages accumulate result high concentrations reactive aldehydes oxidative stress insufficient degradation glycated proteins ages therefore accepted biomarkers aging diabetes several degenerative diseases due warburg effect increased oxidative stress cancer cells frequently accumulate significant amounts ages accumulation ages may reflect metabolic state receptor signaling evaluated potential prognostic predictive value biomarker used immunohistochemistry determine age epsilon carboxymethyl lysine cml mammary carcinoma samples western blotting detect ages cell cultures whereas significant correlation hormone receptor status cml observed cell lines cml accumulation tumors positively correlated presence estrogen receptor alpha postmenopausal state age negative correlation found grade iii carcinomas triple negative cases retrospective kaplan meier survival analysis statistical trend high cml accumulation correlated favorable prognosis relapse free survival rfs tamoxifen treatment estrogen receptor negative cases high cml content significantly correlated unfavorable outcome rfs chemotherapy cml therefore potentially predictive marker treatment breast cancer patients tamoxifen chemotherapy
introductionthis study sought provide preliminary assessment whether spinally mediated afferent hyperactivity central sensitization might contribute manifestations overactive bladder syndrome oab women indexed elevated temporal summation evoked heat pain stimuli methodswe recruited adult women oab planning undergo interventional therapy oab either onabotulinumtoxina injection sacral neuromodulation healthy controls without oab symptoms undergo quantitative sensory testing cutaneous thermal pain temporal summation primary study outcome degree temporal summation reflected magnitude positive slope line fitted series stimuli degrees target temperatures linear regression analysis covariance utilized compare degree temporal summation study groups resultsthe standardized slope temporal summation trials women oab significantly higher controls confidence interval adjusted means standardized temporal summation slopes full oab control groups confidence interval confidence interval respectively conclusionin preliminary study demonstrated women oab refractory primary secondary therapies exhibited greater thermal cutaneous temporal summation women without oab symptoms suggests central sensitization indexed temporal summation may underlying factor contributing oab women neurourol urodynam wiley periodicals inc
paper proposes discrete optimal control method based multi rate digital observer multi sensor network systems many multi sensor network systems sensing time ratios generally different identical estimation time applied fastest measuring time design observer spite repeatability output signals sensed slower measuring time paper proposes optimal control method based kalman filter store repeated signals memories order avoid unnecessary processes proposed control system operated according slow measuring time signals calculated estimate system states without repeated data proposed design method discrete observer develops performance low level microcontroller slow operating abilities since controller able actuate slow operating time without loss output information using simple data storage systems optimal stability controlled system verified according separation principle linear quadratic gaussian system single time ratio
migraine considered disabling disorder highly prevalence population recent studies report migraine patients cognitive decline associated structural brain alterations search pubmed web science databases screening references included studies review articles additional citations studies identified met inclusion criteria studies conducted migraineurs non migraine headache controls subject examined association migraine cognitive impairment results discordant indeed cognitive deficits attack migraine recognized studies confirmed presence cognitive impairment migraine patients given prevalence migraine population especially among women early age population association migraine cognitive impairment could substantial public health implications future studies determine specific migraine characteristics example attack frequency may impact association migraine cognitive decline
granulomatous dermatitis associated hematologic disorders including myelodysplastic syndromes describe first case granulomatous dermatitis associated polycythemia vera presenting large erythematous nodules mimicking panniculitis also present seventh case associated myelodysplasia erythematous plaques face neck similar neutrophilic dermatosis consider particularly interesting dermatologists aware dermatosis nonspecific manifestation various hematologic disorders suggest performing additional tests complete blood count exclude possibility skin manifestations initial sign hematologic disease furthermore propose using broader term granulomatous dermatitis refer disorders although reports interstitial forms cases nodular presentation also published importance diagnosis derives subtype relationship underlying disease elsevier espana aedv rights reserved
purpose regenerative braking control hybrid electrical vehicles recent studies suggested controlling slip ratio electric powered wheel slip tracking controller requires accurate slip estimation overall range slip ratio contrary conventional slip limiter abs calls accurate slip estimation critical slip area estimated around several applications considering possible directly measure slip ratio wheel problem estimate latter available online data estimate slip wheel wheel speed vehicle speed must known several studies provide algorithms allow obtaining good estimation vehicle speed hand proposed algorithm conditioning wheel speed measurement indeed noise included wheel speed measurement reduces accuracy slip estimation disturbance increasingly significant low speed low torque herein two different extended kalman observers slip ratio developed first calculates slip ratio data provided observer vehicle speed propeller wheel speed second observer uses original nonlinear model slip ratio function electric motor sinus tracking algorithm included two observers order reject harmonic disturbances wheel speed measurement moreover mass road uncertainties compensated coefficient adapted online rls algorithms implemented tested three wheel recreational hybrid vehicle experimental results show efficiency methods elsevier ltd rights reserved
study introduced sound transmission mechanisms current situation application selective criteria musical instruments materials summarized major problems musical instrument manufacturing engineering well feasibility artificial board materials alternative material musical instruments application prospect artificial board materials widely musical instrument manufacturing materials elaborated study aimed providing scientific theory musical instrument manufacturing engineering
inhalation fungus cryptococcus neoformans neoformans results pulmonary cryptococcosis associated dependent type immunity lung epithelium represents initial contact site infection role type immunity analyzed source cytokine effect lung epithelial cell function pulmonary cryptococcosis remained unclear mice infected neoformans identified alveolar type epithelial cells major source positive negative epithelial cells receptor expression detectable therefore studied role receptor expression synthesis fungal infection lung epithelial cells found auto paracrine induction next effect epithelial cadherin expression cell cell adhesion molecule analyzed fungal infection resulted cadherin downregulation dependent manner pulmonary epithelial cells single cell population level hand epithelial cells infected mice upregulated surfactant protein cxcl mrna production together independently conclusion lung epithelium represents significant source pulmonary cryptococcosis regulated dependent also independent manner lung epithelium represents significant source pulmonary cryptococcosis regulated dependent also independent manner lung epithelium represents significant source pulmonary cryptococcosis regulated dependent also independent manner
sports injuries common occurrence caused multitude factors typically classified either acute chronic pharmacist strong position provide advice best way manage many injuries treatment approaches include nonpharmacological pharmacological topical medications extremely useful management minor sports injuries generally well tolerated available counter provide rapid relief medpharm
background several computerized adaptive tests cats proposed facilitate assessments mental health tests built standard way disregarding useful usually available information included assessment scales could increase precision utility cats history suicide attempts methods using items previously developed scale suicidal risk compared performance standard cat decision tree support decision system identify suicidal behavior included history past suicide attempts class separation patients decision tree results decision tree needed average four items achieve similar accuracy standard cat nine items accuracy decision tree obtained cross validations shortened test adapted separation suicidal non suicidal patients developed conclusion cats useful tools assessment suicidal risk however standard cats use information available decision tree improve precision assessment since constructed using priori information elsevier rights reserved
many differences different operating systems intelligent equipment application software adaptation workload multiplied based html cross platform development framework phonegap sencha touch titanium appcan easily solve cross platform problem reduce software development cycle costs software development maintenance paper mainly introduced phonegap sencha touch titanium appcan cross platform development framework compared advantages disadvantages analyzed advantages disadvantages cross platform mobile hybrid mobile development mode based html finally paper looked forward development html development technology cross platform hybrid mobile application based html
user performance highly correlated design variables system association described display control relationship study neural network based methodology proposed identify quantify association among design variables inputs compute relative influences ris two performance measures outputs user response time response accuracy using artificial neural network generalised regression neural network support vector regression svr multiple linear regression response surface model based results comparison found neural network based methods reliable svr based methods computing design variables result analysis best option optimising measures suggested useful observations design man machine systems also presented discussed visualised study man machine systems quantitative methods seldom adopted examining mappings various displays controls variety operating conditions major contribution study provide insights usefulness quantitative methods evaluating man machine design terms display control compatibility extract explanatory information renowned black box systems neural networks
design tunable broadband metamaterial absorber mid infrared region based graphene unit cell proposed metamaterial absorber consists circular gold patches coupled graphene layer separated dielectric spacer gold film bottom absorption bandwidth effectively extended patterning multi circular gold patches different dimension elements appropriate geometrical parameters plane metamaterial absorber achieves frequency tunable characteristics via changing applied voltage chemical doping manipulate graphene fermi energy analyzed surface current distributions distributions component electric field understanding absorption mechanism moreover design principle could regarded template extend bandwidth introducing circular patches unit cell design potential applications various fields stealth technology photovoltaic devices sensors broadband communication elsevier rights reserved
diagnostic criteria borderline personality disorder bpd mood psychotic disorders characterized major mood episodes major depressive bipolar schizoaffective disorder share marked overlap symptom presentation complicating differential diagnosis current study tests hypothesis maladaptive interpersonal schemas mis characteristic bpd major mood disorders one hundred psychiatric inpatients assessed scid scid young schema questionnaire ysq logistic regression analyses tested association mis measured ysq bpd bipolar major depressive schizoaffective disorder receiver operator characteristic roc curve analyses assessed sensitivity specificity mis marker bpd covariation comorbidity mood disorders bpd robustly associated schema domains contrast one fifteen regression analyses demonstrated significant association mood disorder schema domain covariation comorbid bpd roc analyses schema domains suggested disconnection rejection greatest power identification bpd cases data support specific role maladaptive interpersonal schemas bpd potentially contribute greater conceptual clarity distinction bpd major mood disorders elsevier ireland ltd rights reserved
software development become fundamental process business organization consequence together emergent technologies new development platforms ides created mainly cloud eclipse orion cloud codio requiring different approaches way software development studied empirical studies software development often based data taken software configuration management repositories source code management systems issue tracking tools ides record data publically regarding developers activities aim bring forward new insights software development process analyzing developers use ide based upon process mining techniques process discovery conformance checking missing perspective hopefully allow discovery coding patterns search programmer behaviors detection deviations prescribed processes finally expect provide advice individual software process enhancement
cancer patients often experience weight loss caused protein calorie malnutrition pcm course disease treatment pcm expressed severe patient two following characteristics obvious significant muscle wasting loss subcutaneous fat nutritional intake week month months cancer anorexia cachexia syndrome cacs multifactorial condition advanced pcm associated underlying illness case cancer characterized loss muscle without loss fat mass cachexia defined weight loss body weight months less presence chronic disease hence chronic illness board even small amount weight loss open door cachexia nutritional challenges lead severe morbidity mortality cancer patients clinic application personalized medicine ability withstand toxic effects anti cancer therapies optimized patient nutritional homeostasis free anorexia cachexia routine assessment nutritional status appropriate intervention essential components effort alleviate effects malnutrition quality life survival patients
background composition skin microbiome predicted play role development conditions atopic eczema psoriasis rrna gene sequencing allows investigation bacterial microbiota significant challenge field development cost effective high throughput methodologies robust interrogation skin microbiota biomass low describe validation methodologies rrna ribosomal ribonucleic acid gene sequencing skin microbiome using illumina miseq platform selection primer amplify regions sequencing compare results current standard protocols methods dna obtained two low density mock communities diverse bacterial strains without human dna supplementation swabs taken skin healthy volunteers amplified using primer pairs covering hypervariable regions rrna gene primers resultant libraries indexed miseq roche sequenced data sets denoised cleaned chimeras analysed using qiime results significant difference diversity indices phylum genus level observed platforms capture diversity using low density mock community samples demonstrated primer pair spanning hypervariable region better capture compared primer pair region robust spiking human dna pilot data generated using region skin healthy volunteers consistent results even genus level staphylococcus propionibacterium corynebacterium paracoccus micrococcus enhydrobacter deinococcus identified similar abundances platforms conclusions results suggest bacterial community diversity captured using rrna hypervariable region sequencing using miseq platform comparable roche junior platform findings provide evidence optimised method used human clinical samples low bacterial biomass investigation skin microbiota
aims investigation fecal retention using objective patient friendly tools rather diagnosis constipation might important management overactive bladder oab children present study aimed evaluate incidence grade fecal retention children oab determine effectiveness laxative treatment fecal retention management oab children methods study included children oab aged years fecal retention defined type feces bristol stool form scale leech score eight points constipation determined according rome iii criteria among children fecal retention constipation treated oral laxatives polyethylene glycol lactulose weeks responses treatment assessed results among children leech score eight points assessed plain abdominal radiography type feces bristol stool form scale functional constipation none either among children received laxative treatment weeks reported improvement oab symptoms additionally number children leech score eight points significantly higher good response group poor response group conclusion investigation fecal retention leech scoring system laxative treatment might helpful management oab children wiley periodicals inc
deformation measurement large measuring deformation monitoring bridge bridge structurally controlled important part long term monitoring diagnosis health article comprehensively analysis contemporary advanced measuring equipment new technology gps global positioning system surveying robots measuring digital close range photogrammetry system formulates advanced reasonable surveying measurement make corresponding data processing software create real time monitoring system large bridges monitoring data analysis management system formed complete bridge suitable large deformation measurement theory techniques ensure normal operation large scale bridge building quality great significance large scale bridge cost high strategic significance many ways transportation military social life predicted next years long span bridge still growth rapidly large scale bridge influenced many aspects construction operation process construction bridge typical time dependant structure close relationship construction technology addition attack corrosion environment dynamic loading vehicle wind damage structure reduce resistance affect service life bridge vigorous development transportation industry bridge load tends increase new structure new materials new technology test technology bridge engineering constantly developing improving increasingly valued people bridge monitoring divided experiment monitoring construction monitoring order study changes bridge must measure variety size geometric quantities characteristics large scale example cable stay bridge suspension bridge large span high tower flexibly main span therefore necessary bridge monitoring used geodesy special engineering surveying instrument methods
work addresses solution problem active vibration suppression cantilever beam using piezoelectric actuation purpose taking advantage effectiveness positive position feedback control strategy ppf order control first mode vibrations analyzed beam control technique well known literature modal control method vibration attenuation ppf controller accomplishes best performance tuned properly characteristics structure controlled according going realize modal analysis cantilever beam utilizing finite element method ansys determine structural frequency corresponding first mode used ppf controller frequency hand shall obtain state space representation cantilever beam using subspace identification method frequency domain applying fast fourier transformation fft furthermore simulate discrete time ppf controller using matlab simulink lastly simulink designed discrete time ppf controller tested using xpc target real time system published elsevier ltd
background maintaining improving skin health patients long term care receivers widely agreed upon goal health nursing care care dependent aged persons high predisposition develop dry skin conditions objectives aim study estimate prevalence severity skin dryness hospitals nursing homes identify person health related variables associated skin condition design study part bigger annual multicentre descriptive cross sectional prevalence study health problems settings participants fourteen nursing homes six hospitals germany participated study total subjects long term care residents patients included methods skin assessments conducted skin dryness measured using overall dry skin score mobility measured using respective item care dependency scale demographic functional physiological parameters compared subjects without dry skin logistic regression model predicting skin dryness created results prevalence skin dryness nursing home residents often affected compared patients skin feet legs often affected skin dryness compared skin areas older pruritus oncological musculoskeletal diseases skin care independent strongest covariates presence dry skin multivariate model conclusions based large sample results indicate approximately every second nursing home resident hospital patient affected dry skin severe forms occur often hospital patients compared nursing home residents skin care interventions tackle dry skin recommended particularly hospital patients nursing home residents affected pruritus oncological diseases need washing bathing assistance musculoskeletal diseases elsevier ltd rights reserved
purpose study examine health children born cosmetologists compared health children women working occupations cross sectional data analyzed cosmetologists women occupations aged years reported least one live birth repeated measures modeling used account lack independence among multiple pregnancies per participant results showed cosmetologist occupation associated child learning disorder however strength association attenuated odds ratio statistically significant confounder adjustment cosmetologist occupation associated adverse health outcomes among children born women occupation including urinary kidney health problems findings indicate cosmetologists increased risk child medical problems compared women occupations elsevier inc rights reserved
development plug hybrid electric vehicles phevs stimulated need replace nonrenewable energies sustainable environment friendly new energy types phevs benefit combination internal combustion engine electric motor rechargeable larger battery pack conventional hybrid vehicles order maximise customer satisfaction motivate replacement conventional vehicles new technology design phevs requires sufficient differentiation product specifications diverse market segments added set time processes costs longer lead time designing manufacturing diverse range vehicles hurdle towards increasing diversity study proposes efficient product family design pfd method mass customisation phev powertrains methodology less dependent expensive simulations due use metamodelling non conventional sensitivity analysis pfd concept implications family five phevs investigated benefits well limitations sustainable development complex product discussed
background national surgical adjuvant breast bowel project international breast cancer intervention studies ductal carcinoma situ trials showed similar treatment effects anastrozole tamoxifen reducing cancer recurrence risk among ductal carcinoma situ dcis patients studies shown low levels hormone therapy drug initiation dcis patients current body literature lacks information year adherence rates drugs population based studies methods study evaluated initiation year adherence levels women aged years diagnosed estrogen receptor positive dcis according surveillance epidemiology end results texas cancer registry databases linked medicare claims chi square tests trend tests logistic regression used identify factors associated treatment initiation results women positive dcis approximately began treatment tamoxifen aromatase inhibitors ais within year dcis diagnosis median age years users years nonusers women aged years underwent lumpectomy radiation therapy significantly likely initiate hormone therapy initiation therapy also significantly associated patients geographic location education marital status diagnosis year race ethnicity among users adherence decreased first year fifth year conclusions initiation adherence levels tamoxifen ais among older women positive dcis low future studies develop methods ensure informed discussions take place health care providers patients regarding hormonal therapy cancer prevention american cancer society
background sub saharan africa adults living hiv women uganda hiv prevalence women compared men access antiretroviral therapy art prevention mother child transmission pmtct programs enabled women living hiv wlwh children minimal risk perinatal transmission nevertheless pregnant wlwh face many challenges explored women perceptions cope challenges pregnancy postpartum period hiv infected women methods conducted semi structured interviews postpartum wlwh accessing art pregnancy within years prior recruitment february august childbearing associated stressors coping strategies discussed used content analysis identify major themes nvivo software facilitated data analysis results twenty women interviewed median age iqr years cell count cells iqr number live births iqr number living children iqr summarize five identified coping strategies within socio ecological framework according bronfenbrenner ecological model coping strategies individual level included acceptance self hiv status self reliance interpersonal level participants reported coping support partners family friends organizational level participants reported coping hiv related healthcare delivery system supports community level women reported coping support church spirituality conclusions results highlight coping strategies used wlwh manage myriad challenges faced pregnancy postpartum period intervention programs wlwh must emphasize psychosocial care incorporate strategies address psychosocial challenges hiv care package order optimize well additionally policies support networks wlwh put place funding support provided existing funding mechanisms order respond needs challenges wlwh programmes support wlwh economic empowerment improved livelihoods strengthened across regions country
relatively new form human communication video conferencing become popular video technology improves increasing demands real time communication across greater distances full effects video conferencing human communication still explored video conferencing presumed somewhat richer form communication email telephone quite informative face face communication review explores research influence eye contact communication video conferencing mediates verbal non verbal interactions facilitation eye contact challenge must addressed video conferencing approach rich interactions face face communication elsevier rights reserved
method estimate line parameter power grid based innovation graph proposed method identifies network parameter error location according feature innovation values branch parameter error correlated branches larger branches network estimates real parameter value based kirchhoff voltage law using pmu measurements method identify estimate network parameter errors quickly simply effectively calculation example ieee bus system demonstrates method estimate network parameter errors exactly example shows method also effective network parameter errors bad data topology errors take place time
individual experiences childhood parented likely key determinants later parenting experiences childhood sexual abuse csa arguably toxic experience occur childhood therefore may particularly likely impact parenting stress context parenting one children paper aims review studies investigating associations earlier csa later parenting determine size consistency effects identify mediators moderators relationship assess quality evidence base psycinfo academic search complete cinahl medline web science pubmed pilots searched date inception march studies met inclusion criteria seven studies indicated degree direct association experiencing csa later parenting stress two studies found association five studies suggest variables locus control current stressors may affect relationship csa parenting stress additionally studies suggest indirect relationship csa parenting stress current level depression results suggest existence relationship csa parenting stress though association mostly mediated variables including depression stressors clearer definitions csa use validated questionnaires essential progress field research
late advanced iso thermal extrapolation approach referred licon methodology developed european brite euram project predict long term creep rupture behaviour new generation steels methodology relies multiaxial loading conditions accelerate onset long time creep damage formation short time rupture regime licon method therefore enables prediction long time uniaxial creep rupture strengths using results several short duration multiaxial creep crack initiation tests conjunction outcome mechanical analysis adopted multiaxial specimen geometry paper briefly reviews latest findings concerning application licon method different types materials successful applications method long time creep rupture strength predictions advanced martensitic pipe steels low alloy ferritic steel crmov dissimilar metal weld crmov inconel inconel successfully achieved last years evaluations well proven applicability licon concept different types engineering materials time emphasising need consideration appropriate mechanical analysis tools assessment multiaxial geometry used creep crack initiation tests dependent type material structure investigation consideration complex multiaxial stress state developing within constituent parts weidments even within uniaxial testpiece elsevier ltd rights reserved
practice complexity contract management enterprise construction project construction contract management performance evaluation often simple qualitative analysis perfect construction contract management performance evaluation theory system based background first perspective harmonious theory analysis construction contract management elements mechanism introducing theory harmonious model second theoretical analysis present situation research data establish harmonious construction management performance evaluation models five aspects parsing harmonious theme realization application calculation model performance evaluation harmonious degree finally put forward corresponding conclusions recommendations
rebound effect studies road vehicle travel focus mostly increases distance traveled increases energy efficiency average journeying speed also increases energy efficiency rebound studies avoid quantifying speed related rebound effects may underestimate rebound effects around study offers first attempt show increases speed acceleration contribute rebound effects quantified empirical data dynamometer test results plug electric car internal combustion engine ice pick van automatic transmission wltp nedc drive cycles representing driving styles today respectively rebound effects estimated comparing wltp nedc results using typical energy efficiencies nedc electric car shows speed rebound effect mathematical development sets speed rebound effects included traditional rebound effect analyses results ice vehicle allow direct rebound effect estimate due wasteful engine revving nedc wrong gear ratios sedate travel however seen form transformational rebound effect vehicle design locks drivers fast driving styles elsevier ltd rights reserved
microbiome located within given host organs foinis holobiont intimate functional entity evolutionarily designed interactions support nutritional intake reproduction thus organs holobiont respond changes within microbiome development function central nervous system homeostatic mechanisms arc exception arc also subject regulation gut microbiome order holobiont function effectively microbiome host must communicate aryl hydrocarbon receptor evolutionarily conserved receptor recognizing environmental compounds including number ligands produced directly indirectly microbiome review focuses microbiomegut brain axis regard aryl hydrocarbon receptor signaling pathway impact underlying mechanisms neurodegeneration
digital technology widely used field implant dentistry surgical standpoint computer guided surgery utilized enhance primary implant stability improve precision implant placement prosthetic standpoint computer aided design computer assisted manufacture cad cam technology brought various restorative options including fabrication customized abutments virtual design based computer guided surgical planning case report describes novel technique combining use three dimensional printed surgical template immediate placement implant cad cam technology optimize hard soft tissue healing bone grafting use socket sealing abutment
background detailed information health care costs productivity costs whole spectrum injuries lacking measured total costs injuries external cause injury groupings age sex method injury patients visiting emergency department netherlands included health service use work absenteeism estimated national database data prospective followup study health care costs direct costs productivity costs indirect costs determined using incidence based dutch cost injury model results total costs injuries sic billion annually sic capita sic patient sic billion healthcare costs sic billion productivity costs home leisure injury subcategory falls caused total costs traffic injury prominent age group mainly due bicycle injuries sports injuries special football soccer injuries resulted high costs age group although costs per patient comparable males females health care costs higher females whereas males twice high productivity costs health care costs highest hip fractures sic patient extremity fractures high costs due high incidences high productivity costs per patient conclusion detailed cost model identified known risk groups elderly females hip fractures resulting falls well less obvious important high risk groups young children falling furniture young males sustained football soccer injuries bicycle injuries among ages information essential assess additional priority areas prevention elsevier ltd rights reserved
need populate fusion materials engineering data base long recognized ifmif facility present proposed neutron source purpose evaluation regulatory approach proposed demo device shows specification neutron source reduced respect ifmif allowing lower risk technology solutions considered justification approach presented description proposed facility fafnir presented detailed discussion accelerator target designs euratom ccfe fusion association published elsevier rights reserved
background glenoid component positioning reverse shoulder arthroplasty rsa challenging patient specific instrumentation psi advocated improve accuracy based precise preoperative planning purpose study determine accuracy glenoid component positioning glenoid surface visible compared entire scapula visible virtual model methods scans arthritic shoulders reconstructed models two surgeons virtually placed glenosphere component model visualizing glenoid surface order simulate typical intraoperative exposure blind surgery one surgeon placed component ideal position visualizing entire scapula visible surgery two positions compared accuracy glenoid component positioning assessed terms correction native glenoid version tilt avoidance glenoid vault perforation results mean version tilt blind surgery degrees degrees degrees degrees respectively glenoid vault perforation occurred specimens mean version tilt visible surgery degrees degrees degrees degrees respectively glenoid vault perforation cases visible surgery provided significantly better accuracy blind surgery conclusion entire scapula used reference accuracy improved glenoid vault perforation less frequent type visualization possible pre operative planning may augmented psi published elsevier masson sas
aim study survey exact benefit herb management clinical laboratory signs symptoms allergic rhinitis randomized double blind clinical trial patients signs symptoms allergic rhinitis positive skin prick test selected randomly divided groups taken urtica dioica urtidin tablet placebo one month signs symptoms eosinophil percentage nasal smear serum ige interleukin interferon gamma levels recorded forty patients completed trial based sino nasal outcome test snot significant improvement clinical symptom severity observed groups furthermore statistically significant reduction mean nasal smear eosinophil count observed treatment nettle intergroup pre post treatment laboratory findings suggested significant difference post treatment changes mean ifn levels study placebo group although current study showed certain positive effects nettle management allergic rhinitis controlling symptoms based snot similar effects demonstrated placebo well believe limitations underscore need larger longer term studies nettle treatment allergic rhinitis
qualitative phenomenological study analyze seasonal affective disorder sad adolescents since end winter great number adolescents diagnosed winter depression attended community mental health center madrid spain another group adolescents attended autumn symptoms always serious specially women deliberately injured suicidal purpose symptoms non described sad appeared intrusive flood ruminative thoughts marked variability symptoms intensity irregular periods self injuries self injuries behaved distracting purpose order interrupt ruminative thought call process cognitive emotional maelstrom chance phenomenon could belong sad subtype concerns hot climate countries ruled approval sad may concern warmer countries could help diagnosis treatment
highly recognized difficulties involved teaching programming introductory course arise cognitive process complexity necessary developing ability previous studies best first programming language best first programming paradigm conducted even appropriate integrated development environment ide novice programmers inquired appropriate problem solving strategy teach write computable solutions researched investigation sample bogota universities holistic perspective paper presents overview common practices difficulties teaching courses providing important information help diagnose possible weaknesses current process teaching well providing elements consider design new strategies resources planning criteria formative scenarios
work present efficient implementation canonical monte carlo simulation coulomb many body systems graphics processing units gpu method takes advantage gpu single instruction multiple data simd architectures adopts sequential updating scheme metropolis algorithm makes approximation computation energy reaches remarkable fold speedup compared serial implementation cpu use method simulate primitive model electrolytes measure precisely ion ion pair correlation functions high concentrations data extract renormalized debye length renormalized valences constituent ions renormalized dielectric constants results demonstrate unequivocally physics beyond classical poisson boltzmann theory elsevier inc rights reserved
low temperature cracking potential primary concern asphalt mixtures high rap contents minimize thermal cracking various rejuvenators utilized past study fourier transform infrared spectroscopy ftir used determine level oxidation asphalt evaluate low temperature cracking potential aged asphalt without rejuvenators fracture surface images captured using cryo scanning electron microscopy cryo sem cryo sem images analyzed using image processing technique rejuvenated asphalt specimens exhibited less fractured surface aged asphalt finally fracture index computed rank asphalt sample terms low temperature cracking potential based test results concluded use cryo sem technology combined image processing technique promising method visually observe fracture surface asphalt compute fracture index estimate low temperature cracking susceptibility elsevier ltd rights reserved
frame structure stacker cranes non stationary phases movement due inertial forces undesirable mast vibrations may occur effect reduce stability positioning accuracy machines aim paper introduce accurate quite simple dynamical model single mast stacker cranes suitable investigating mast vibrations machines multi body modelling approach selected generate differential equations motion model solution equations performed means called modal coordinate transformation modal superposition method model structural damping taken consideration means called proportional damping rayleigh damping approach main advantage presented multi body model model mast vibrations investigated various positions mast dynamic models varying lifted load positions also generated simple way using introduced modelling technique main properties state space representation model well time domain simulation results also introduced
objective understand better relation media violence exposure brain functioning trait aggression study investigated association media violence exposure brain activation measured functional magnetic resonance imaging fmri groups normal adolescents adolescents disruptive behavior disorder dbd aggressive features methods seventy one participants underwent neuropsychologic evaluation assessment exposure violent media subjects also evaluated fmrl performing counting stroop task results frontal lobe activation reduced aggressive subjects compared control subjects addition differences frontal lobe activation associated differences media violence exposure specifically activation performance control subjects high media violence exposure resembled seen dbd subjects conclusions findings suggest media violence exposure may associated alterations brain functioning whether trait aggression present
food eating serve expression social relations roles well mechanism sustaining challenging social structure roles also includes marking reproducing gender roles identities profound social cultural political changes taken place recently poland offers interesting case study grasping changing meaning food gender relationship aim article therefore twofold present available data food choices among men women mostly dietary choices offer sociocultural interpretation data discussing context emerging food regimes recent gender transformations words interested finding food incorporated gender polish context interpreted light scholarly work gender food
studies bone mineral density fracture risk diabetic patients attracted interest last years study aimed comparing mandibular osteoporotic changes assessed qualitative quantitative radiographic methods mandibles type diabetes mellitus patients non diabetic subjects using cone beam computed tomographic images quantitative qualitative study mandibular bone diabetic patients included type diabetes mellitus patients equal number healthy subjects radiomorphometric measurements performed subject using cone beam computed tomography images changes cortical bone thickness determined measuring bone area fractal dimension analysis applied evaluate trabecular structure bone statistically significant difference could established type diabetes mellitus group control group regard either radiomorphometric measurements fractal dimension analysis quantitative assessment mandibular bone indicated thinning cortical bone statistically significant difference type diabetes mellitus patients healthy controls bone condition related diabetes involves complex pathophysiological mechanisms thus radiographic imaging parameters may useful adjunct clinical parameters
simultaneous three dimensional visualization intracranial tumors brain structures skull vessels desired neurosurgeons create clear mental picture anatomical orientation surgical field prior surgical intervention different anatomical pathological components usually visualized separately different magnetic resonance sequences however surgery tackled simultaneously another problem present day workstations enable review two dimensional slices limited postprocessing options recent software developments simultaneous visualization simulating real surgical field possible using commercial open source softwares authors reviewed important concepts described technique interactive visualization routine weighted angiography venography sequences using open source fsl pfunctional mri brain software library brainsuite softwares
partitioning entire electrical network several sub regions good way control voltage reactive power paper effective identification strategy proposed partition whole network typical boundary nodes firstly point normal operation reactive sensitivity relationship matrix reactive power sources formulated partition reactive power source partitions ensure right amount reactive power sources sub region secondly sensitivity relationship matrix calculated figure comprehensive sensitivity reactive power source partition load nodes solve problem boundary nodes partition ambiguity paper presents identification strategy based perturbation increasing load power analysis calculation ieee node system simulation results achieve apparent division boundary nodes partitions avoid ambiguity effectively simulation results ieee node system demonstrate effectiveness partition method
knowing water consumption patterns buildings key information water planning article aims characterize water consumption pattern water end uses low income houses region florianopolis southern brazil data collected interviewing householders well measuring flow rate existing water fixtures appliances results indicated shower fixture largest water consumption households total water consumption average followed toilet surveyed households consumed capita day average based different income ranges correlation found income water consumption results study used estimate consumption water new buildings well develop integrated water management strategies low income developments florianopolis water saving plumbing fixtures rainwater harvesting greywater reuse likely would deferral capital investments new water assets enhancing water wastewater services saving water low income houses
paper propose low complexity graph based linear minimum mean square error lmmse equalizer order remove inter symbol inter stream interference multiple input multiple output mimo communication proposed state space representation inflicted graph provides linearly increasing computational complexity block length addition owing gaussian assumption used presented cycle free factor graph complexity suggested equalizer structure affected size signaling space addition introduce efficient way computing extrinsic bit log likelihood ratio values lmmse estimation compatible higher order alphabets shown perform better methods literature overall provide efficient receiver structure reaching high data rates frequency selective mimo systems whose performance shown close genie aided matched filter bound extensive simulations
serodiagnosis tegumentary leishmaniasis presents problems related sensitivity specificity tests present study enzyme linked immunosorbent assay elisa technique used evaluate performance leishmania braziliensis hypothetical protein lbhym attempt compare serological reactivity soluble leishmania antigenic preparation sla serodiagnosis cutaneous mucosal leishmaniasis lbhym predicted kinesin like protein bioinformatics tools serum samples collected patients well chagas disease healthy subjects living endemic non endemic areas also sera collected patients treatments seeking evaluate serological follow relation anti protein anti parasite antibody levels elisa rlbhym assay performed proved significantly sensitive elisa braziliensis sla detecting patients also using sera chagas disease patients elisa rlbhym proved specific elisa sla anti protein anti parasite antibody levels also evaluated months treatments treated patients showed significantly lower levels specific rlbhym antibodies compared anti parasite antibody levels conclusion elisa rlbhym assay considered confirmatory serological technique serodiagnosis braziliensis infection also used serological follow treated patients aiming correlate low anti protein antibody levels improvement healthy state patients
alleviate increasingly serious water pollution shortages developing countries various kinds policies implemented local governments vital quantify evaluate performance potential economic impacts policies study develops computable general equilibrium cge model simulate regional economic environmental effects discharge fees firstly water resources water environment factors separated input output sources national economic production department secondly extended social accounting matrix sam jiangsu province developed simulate various scenarios changing values discharge fees increased three scenarios simulated examine influence overall economy industry simulation results show increased fee negative impact gross domestic product gdp however waste water may effectively controlled also study demonstrates along economic costs increase discharge fee lead upgrading industrial structures situation heavy pollution one light pollution beneficial sustainable development economy protection environment
main objectives present studies update explicit gender stereotypes linked sport activities examine whether associated gender age personal practice general feminization rates participation study well investigate potential effects implicit gender sport stereotypes categorization gendered names study perceptions feminine neutral masculine silhouettes study study indicated explicit gender stereotypes still attached sport activities little variations according personal characteristics strong association actual feminization rates study focused implicit stereotypes observed slower identification male names participants primed feminine sport activities study neutral silhouettes frequently categorized women following feminine sport men following masculine sport research suggests sport activities still gendered explicit implicit levels may lead individuals adjust participation even outside consciousness
combination wind turbines fuel cells electrolyzers ely option balancing fluctuating grid power injections renewable energy sources conversion electricity hydrogen via ely often called power gas transforming hydrogen electricity via referred electrification application technologies currently faces high costs finding positive business case challenging study quantifies economic potential marketing ely systems flexibility potential reduce wind farm forecast errors well system ability provide secondary control reserve scr germany investigated purpose data year used different root mean squared errors probability density function pdf forecast errors considered scr dispatch power high temporal resolution approximated different bidding strategies scr market taken account results show applications economically viable also combined however profitability highly dependent system configuration well operating strategy elsevier ltd rights reserved
november october concentrations volatile organic compounds vocs nox simultaneously monitored using online instruments air monitoring station belonged tianjin environmental protection bureau tepb results indicated vocs concentrations higher autumn lower spring concentrations higher summer lower winter diurnal variations vocs nox plus showed opposite tendency comparing concentrations alkanes higher average ppbv aromatics ppbv alkenes ppbv however alkenes aromatics made larger contributions ozone high reactivity tianjin belonged voc limited region seasons except summer according voc nox ratios threshold automobile exhaust industrial emission liquefied petroleum gas natural gas lpg combustion gasoline evaporation internal combustion engine emission solvent usage identified major sources vocs positive matrix factorization pmf model tianjin contributions vocs entire year respectively conditional probability function cpf analysis indicated contributing directions automobile exhaust industrial emission mainly affected source distributions sources might mainly affected wind direction backward trajectory analysis indicated trajectory air mass originated mongolia reflected features large scale long distance air transport beginning jiangsu shandong tianjin showed features small scale short distance tianjin beijing hebei northwest shandong identified major potential source areas vocs using potential source contribution function pscf concentration weighted trajectory cwt models elsevier ltd rights reserved
functional traits plants regions world mediterranean climate shaped tolerate periods water deficit species adapted summer droughts may able cope future increases drought intensity duration frequency review mechanisms traits drought resistance recovery well studied holm oak quercus ilex propose model species mediterranean type ecosystems aim understand differences links responses ilex summer droughts extreme droughts long term drought experiments main goal provide integral picture drought responses across organisational temporal scales identifying relevant processes likely contribute determining future mediterranean vegetation evidence long term drought experiments showed acclimation processes molecular epigenetic changes ecosystem level reductions stand density mitigate effects drought changes leaf morphology hydraulics leaf shoot allometry root functioning among key mechanisms overcoming increasing drought duration drought determines severity terms canopy loss stem mortality although ilex vigorously resprout episodes resilience may subsequently reduced future higher frequency return extreme droughts challenge thus capacity forests recover insights provided review complex interplay processes determine response trees droughts different duration intensity frequency also help understand likely responses resprouting angiosperms seasonally dry ecosystems share similar functional traits ilex
objective objective study report eeg features text messaging using smartphones methods one hundred twenty nine patients prospectively evaluated video eeg monitoring vem months reproducible texting rhythm present active text messaging smartphone compared passive forced audio telephone use thumb finger movements cognitive testing calculation scanning eye movements speech language tasks patients without epilepsy statistical significance set results twenty seven patients identified cohort female mean age range unselected vem patients fifty three patients epileptic seizures nonepileptic seizures nes dual diagnosed reproducible present specific text messaging present patients patients nes absent independent tasks audio cellular telephone use age gender epilepsy type mri results eeg lateralization patients focal seizureswere unrelated conclusions results suggest scalp eeg represents novel technology specific neurophysiological alteration brain networks propose cortical processing contemporary brain uniquely activated use peds significance findings practical implications could impact industry research nonverbal communication elsevier inc rights reserved
renewable energy sources likely become essential due continuously increasing energy demands together depletion natural resources currently used power generation coal gas also advantageous terms reduced environmental impact generation electrical power vortex induced vibration viv cylinder investigated numerically cylinder free oscillate direction transverse incoming flow cylinder attached magnet move along axis coil made conducting wire magnet coil together constitute basic electrical generator cylinder undergoes viv motion magnet creates voltage across coil connected resistive load lenz law induced current coil applies retarding force magnet effectively electrical generator applies damping force cylinder spatially varying damping coefficient initial investigation reported reynolds number restricted flow laminar two dimensional incompressible navier stokes equations solved using extensively validated spectral element based solver effects electromagnetic damping constant coil dimensions radius length mass ratio electrical power extracted quantified found optimal value opt maximum electrical power generated radius length coil increased value opt observed increase although maximum average power remains larger coil radius length results robust system sense relatively large amount power extracted far opt unlike constant damping ratio case average power output also function reynolds number primarily increased maximum oscillation amplitude occurs increased reynolds number least within laminar range although general qualitative findings seem likely carry across high reynolds number viv
background cervical cancer third commonly occurring cancer among women fourth leading cause cancer related deaths women worldwide cases occurring developing countries global disparities reflect differences cervical cancer screening rates high income medium low income countries salvador lowest reported screening coverage latin american countries purpose study identify factors affecting public sector hpv dna based cervical cancer screening participation salvador methods study nested within public sector screening program health promoters used door door outreach recruit women aged years attend educational sessions hpv screening subgroup participants chosen randomly questioned demographic factors healthcare utilization previous cervical cancer screening hpv knowledge women scheduled screening appointments public health clinics screening participants adherent attended scheduled appointment rescheduled screened within months association non adherence demographic variables medical history history cancer sexual history birth control methods screening barriers assessed using chi square tests significance logistic regression results women enrolled study scheduled hpv screening appointments attended non adherence associated higher number lifetime partners screened defined participated cervical cancer screening within previous years respectively participants study screened conclusions adherence cervical cancer screening educational sessions higher expected part due interactions community based health promoters well educational session effective recruitment methods targeted toward screened women required
rheumatic joint diseases exemplified osteoarthritis rheumatoid arthritis among widespread painful disabling pathologies across globe given continuing rise life expectancy prevalence destined grow osteoarthritis degenerative joint disease particular way becoming fourth leading cause disability worldwide rising incidence obesity addition age important factors estimated osteoarthritic individuals unable perform daily activities accompanying osteoarthritis rheumatoid arthritis chronic systemic disease often causes pain deformity least affected unable remain gainfully employed within years disease onset growing body evidence points inflammation locally systemically promoter damage joints bones well joint related functional deficits pathogenesis underlying joint diseases remains unclear however currently believed cross talk cartilage subchondral boneand loss balance two structures joint diseasesis critical element view amplified presence mast cells whose dysregulation associated alterations junction structures cartilage bone synovia matrix nerve endings blood vessels addition persistent activation mast cells facilitates development spinal neuroinflammation mediated interaction microglia unfortunately current treatment strategies rheumatic articular disease symptomatic little limit disease progression research directed therapeutic modalities target osteoarticular structural elements thereby delaying disease progression joint replacement
technology advances systems involving artificial components provide support people potential consequences phenomena examined specific circumstances ambient assisted living instantiation concept intelligent environment chapter describes idea ambient assisted living looks possible ways humans may affected prevalence technology general example assisted healthcare specific example medication support used show systems advancing moreover advancements lead problems artificial systems larger systems involved many cases trade around people loop inevitably need included many decision making processes keeping person loop might also partially redress problems artificial general intelligence systems chapter concludes reflections considerations help retain positive aspects whilst avoiding negative side effects hypothetical technological singularity
electricity load demand estimation remarkable impact economic policies power industry business cycles forecasting movements load demand provides know tendency future lead clear decision strategic planning investments besides ability know fluctuations future values contributes management daily weekly long term operations study aims predict electricity load demand using hybrid method incorporates empirical mode decomposition emd support vector regression svr algorithms proposed emd svr method integrates emd method svr algorithm using emd denoising step training data unlike previous studies proposed algorithm dependent specific intrinsic mode function imf denoising model learning experimental results conducted electricity load datasets different countries proposed method compared svr algorithm using different feature vectors well shown proposed algorithm outperforms svr non feature used denoised svr algorithm electricity load forecasting elsevier ltd rights reserved
angioedema secondary inhibitor deficiency rarely reported associated systemic lupus erythematosus genetic defect inhibitor produces hereditary angioedema usually presented cutaneous painless edema edema genital area gastrointestinal laryngeal tracts also reported lupus patients angioedema may result acquired type inhibitor deficiency probably due antibody formation directed inhibitor molecule herein report new case lupus nephritis developed angioedema rapid course disease progression acute renal failure alveolar hemorrhage without response high dose steroid plasmapheresis
heterogeneous system architecture hsa architecture developed hsa foundation aiming reducing programmability barriers well improving communication efficiency heterogeneous computing example hsa allows heterogeneous computing devices share virtual address space feature allows programmers bypass explicit data copying devices required past hsa features job dispatching user level queues memory based signaling help reduce communication latency host computing devices new features hsa enable efficient heterogeneous computing also introduce new challenges system virtualization especially memory virtualization virtualization work investigates issues involved hsa virtualization implements kvm based hypervisor supports main features hsa inside guest operating systems furthermore work shows newly introduced hypervisor hsa system resources hsa compliant amd kaveri effectively shared multiple guest operating systems
rheumatoid arthritis one prevalent inflammatory rheumatic diseases chronic lifelong destructive disease aim treatment reduce disability improve quality life rheumatoid arthritis quality life raqol questionnaire patient reported outcome measure specific adapt validate raqol use serbia two translation panels involved produce serbian raqol successful translation face content validity determined via cognitive debriefing interviews psychometric properties questionnaire examined including reliability construct validity using nottingham health profile nhp comparator scale raqol translated successfully rated applicable relevant comprehensive respondents questionnaire high internal consistency alpha time points test retest reliability moderately high correlations found raqol physical mobility pain energy level sections nhp providing evidence convergent validity raqol able distinguish patients grouped perceived general health incidence flare disease severity serbian language version raqol showed strong evidence reliability validity recommended use clinical trials routine general practice
given prevalence irritable bowel syndrome ibs suboptimal response therapeutic approaches increasing interest adoption dietary treatment strategies low fermentable oligo mono saccharides polyols fodmap diet fodmaps diverse group carbohydrates exert effects gastrointestinal tract via fermentation likely via alterations microbiota metabolome permeability intestinal immunity well clinical evidence efficacy diet mounting significant questions regarding short long term safety effects microbiota nutrition remain unanswered review article interprets recent findings reported issue neurogastroenterology motility summarizes mechanistic clinical efficacy data low fodmap diet ibs patients date
among patients chronic kidney disease ckd united states hcv infection causes significant morbidity mortality results substantial healthcare costs daily oral regimen elbasvir grazoprevir ebr gzr weeks found safe efficacious treatment hcv patients ckd evaluated cost effectiveness ebr gzr treatment naive treatment experienced ckd patients compared treatment notx pegylated interferon plus ribavirin peg ifn rbv using computer based model natural history chronic hcv genotype infection ckd liver disease data baseline characteristics simulated patients obtained nhanes model inputs estimated published studies cost treatment ebr gzr peg inf rbv based wholesale acquisition cost costs third party payer perspective expressed dollars estimated lifetime incidence liver related complications liver transplantation kidney transplantation end stage live disease mortality end stage renal disease mortality lifetime quality adjusted life years qaly incremental cost utility ratios icur model predicted ebr gzr significantly reduce incidence liver related complications prolong life patients chronic hcv genotype infection ckd compared notx use peg ifn rbv ebr gzr based regimens resulted higher average remaining qalys higher costs compared notx peg inf rbv peg ifn rbv cost effective icur ebr gzr compared notx qaly treatment patient haemodialysis ebr gzr resulted higher icur qaly assuming threshold per qaly gained cost effectiveness use elbasvir grazoprevir treat average patient ckd considered cost effective united states
fifa simple easy implement sports injury prevention program comprising warm conditioning exercises aim systematic review evaluate impact fifa injury incidence compliance cost effectiveness implemented among football players medline embase scopus databases searched using search terms fifa football soccer injury prevention titles abstracts screened two independent reviewers data filtered one reviewer using standardized extraction form thereafter checked another one risk bias methodological quality studies evaluated pedro score critical appraisal skills programme casp total studies identified met inclusion criteria review fifa demonstrated simple exercise program completed part warm decrease incidence injuries amateur football players general considerable reductions number injured players ranging observed among teams implemented fifa addition players high compliance fifa program estimated risk reduction injuries show significant improvements components neuromuscular motor performance participating structured warm sessions least times week studies high methodological quality low risk bias given large number people play football amateur level detrimental impact sports injuries personal societal level fifa considered fundamental tool minimize risks participation sport substantial health benefits
rockbursts frequently encountered construction deep tunnels jinping hydropower station southwest china investigations possibility rockbursts tunnel boring machine tbm drilling blasting advancement necessary guide construction tunnels protect personnel tbm equipment strainburst related accidents real time movable microseismic monitoring system installed forecast strainburst locations ahead tunnel faces spatiotemporal distribution evolution microseismic events prior strainbursts recorded analysed concentration microseismic events prior occurrence strainbursts found significant precursor strainbursts deep rock tunnelling year microseismic investigation strainbursts deep tunnels jinping hydropower station total strainburst location forecasts issued correctly forecasting locations strainbursts successful forecasting strainburst locations proved microseismic monitoring essential assessment mitigation strainburst hazards used minimise damage equipment personnel results current study may valuable construction management safety assessment similar underground rock structures high situ stress
china rapid economic development greatly affected global economy also entire environment earth forecasting china economic growth become popular essential issue present forecasts nearly conducted national scale study use nighttime light images gridded landscan population dataset disaggregate gross domestic product gdp reported province scale per pixel level using disaggregated gdp time series data statistical tool holt winters smoothing predict changes gdp kmxkm grid area aggregate pixel level gdp forecast economic growth major urban agglomerations china elaborate demonstrate lit population brightness nighttime lightsxpopulation better indicator brightness nighttime lights estimate disaggregate gdp also show forecast gdp high agreement national bureau statistics china demographic data international monetary fund predictions finally display uncertainties analyze potential errors disaggregation forecast method
engineers able produce creative products much required everywhere however classical engineering courses especially courses first two years career tend content intensive focused technical skills little space foster creativity result faced requirement devising creative product engineering students often unprepared paper show introduction design methods year engineering course computer programming significantly improved novelty final term projects design method selected according stage creative process course going preparation incubation illumination verification hypothesis blending design engineering teaching enough time creative process novel ideas emerge fluently paper provide weekly description course activities results obtained expect work helps design engineering courses towards design engineering blended teaching trigger creative thinking
wind turbine generator difficult achieve good control performance using conventional pid variable pitch controller multi variables nonlinearities controller based principles variable pitch control wind generating set study introduces mathematical model wind turbine generators proposes variable pitch fuzzy pid control method combining fuzzy control pid control methods effectively overcome deficiencies conventional pid controller order enhance self learning predictability system improved method variable pitch control fuzzy pid proposed based online support vector machine svm finally simulation comparisons show fuzzy pid variable pitch control based svm improves control performance variable pitch wind turbine generator addition robust random wind speeds adjust pitch angle smoothly ensures stable output power wind turbine generator thus effectively improving control performance variable pitch system wind generating set
circadian rhythm alterations implicated multiple neuropsychiatric disorders particularly sleep addiction anxiety mood circadian rhythms known maintained set classic clock genes form complex mutual self regulatory loops many genes showing rhythmic expression identified genome wide studies roles circadian regulation remain largely unknown attempts directly connect circadian rhythms neuropsychiatric disorders genetic studies identified gene mutations associated several rare sleep disorders sleep related traits genetic studies circadian genes psychiatric disorders limited success important mediator environmental factors regulators circadian rhythms epigenetic system may hold key etiology pathology psychiatric disorders subtypes endophenotypes epigenomic regulation circadian system related changes thoroughly explored context neuropsychiatric disorders argue systematic investigation circadian system particularly epigenetic regulation involvement neuropsychiatric disorders improve understanding human behavior disease etiology
background epidemiological research believed underestimate lifetime prevalence mental illness due recall failure lack rapport researchers participants method prospective study examined lifetime prevalence morbidity rates substance use disorders antisocial personality disorder aspd major depressive disorder mdd representative statewide minnesota sample assessed four times ages years low attrition results lifetime prevalence rates disorders doubled ages years men women prospective rates age years consistently higher rates leading epidemiological surveys although variation general trend lifetime morbidity increase ages years trend significant mdd alcohol dependence mdd nicotine dependence aspd nicotine dependence conclusions overall results show emerging adulthood high risk period development mental illness increases lifetime prevalence morbidity mental disorders time quarter individuals met criteria mdd fifth experienced alcohol dependence age years indicating mental illness common estimated cross sectional mental health surveys findings important implications measurement economic burden resource allocation toward mental health services research advocacy organizations mentally ill etiological theories mental disorders
interleaved multilevel converters advantages low voltage stress switches diodes reduction filter size particularly series input parallel output isop configuration well suited high output voltage large output current application input series output series isos configuration enable utilization low voltage rating switches high voltage input high voltage output applications require galvanic isolation series connection isolated converters input side also used higher voltage application multilevel topology offers many new features also necessitates balance control input capacitors paper describes operating principles balancing circuit analyzes fundamental relationships introduces principles operation circuit paper shows experimental results based practical application examples paper discusses design transformer balancing winding isop isos parallel connection converters provide independent voltage balancing input capacitors
background purpose hiv aids significant public health issue individuals living united states federal agencies key stakeholders recommend routine hiv aids screening among individuals aged age yet studies focus nurse practitioner perspective purpose study examine routine hiv screening intentions behaviors practices using national sample nps methods cross sectional study utilizing random sample nps american association nurse practitioners organization total nps returned complete responses paper pencil questionnaire included study conclusions one quarter nps reported routine hiv screening behavior half reported intentions increase routine hiv screening next year hiv screening practices reported risk based patient initiated among sample nps implications practice healthcare system nps serve leaders primary secondary prevention screening identifying individuals unaware hiv infection greater coordinated efforts new system approaches needed help nps adapt hiv screening recommendations practice guidelines
modeling solving transcendental eigenvalue problem important issues transfer matrix method linear multibody systems based recursive eigenvalue search algorithm transfer matrix method linear multibody system distributed parallel approach assembling overall transfer matrix searching eigenvalues proposed achieved based message parallel interface influence cpu core number well distributed network environment final computational time analyzed numerical examples non uniform beam multiple launch rocket system results indicate computational time significantly reduced proposed parallel computing method computational efficiency optimization design complex multibody systems improved
solar energy building applications may significantly reduce conventional energy consumption related carbon dioxide emissions comprehensive utilization integrated solar thermal photovoltaic systems undoubtedly subject interest present paper optimization model proposed integrated solar energy systems aiming figure optimal utilization economical efficiency solar energy resources buildings cold plateau areas case study lhasa city carried order evaluate energy economic performance developed model results indicated solar photovoltaic systems preferred solar thermal systems typical office buildings cold plateau areas rich solar energy resources addition sensitivity analysis performed investigate influences financial subsidies commercial electricity prices system economical performance furthermore life cycle assessment conducted compare analyze performances optimization system conventional system elsevier ltd rights reserved
aimto understand experiences caregivers older people living thailand particularly related quality life stress management methodin depth interviews family caregivers conducted data thematically analysed resultscarers experience negative impacts also positive impacts caregiving negative impacts include emotional stress financial struggles worry due lack knowledge positive impacts include affection care recipients good relationships caregivers needing care encouragement wider community opportunities show gratitude build karma good deeds ideas shaped largely buddhist teachings result positive experiences negotiating extremes bliss suffering understanding suffering part life may help carers manage stress conclusionstemples centres older people could engaged develop caregiving programs
human body expresses host defense peptides proteins antimicrobial peptides amps compounds produced tissues mucosal surfaces skin digestive urinary tract ocular surface neutrophils believed play crucial role defense microbial infection considered protect human body microbial infections due antimicrobial immunomodulatory activities well strong antimicrobial activity towards broad spectrum microorganisms amps found interact neutrophils monocytes cells promote production cytokines also neutralize action lipopolysaccharide lps play crucial role wound healing processes response microbial stimuli amps released order fight infection however several microorganisms evading human immune system downregulation amps decreased elevated expression amps associated also several non infectious diseases despite numerous studies conducted field amps last decades exact role physiological pathological processes remains explained paper review significant human amps potential roles maintaining human homeostasis well pathological processes
testosterone therapy recommended men symptomatic androgen deficiency unequivocally low testosterone levels although prevalence hypogonadism seems relatively constant studies prescribing patterns united states united kingdom show dramatic increase testosterone prescription recent years possibly due increased marketing inappropriate therapy concurrent growing concern regarding potential adverse effects testosterone therapy particularly cardiovascular risks review present current understanding implications testosterone deficiency well conflicting evidence surrounding cardiovascular effects testosterone replacement therapy although lack adequate data based current evidence conclude testosterone therapy safely considered men appropriately diagnosed clinical androgen deficiency increased cardiovascular risk thorough discussion potential risks guideline recommended safety monitoring
background cysteinyl leukotriene receptor cysltr cysltr involved allergic processes play role adenotonsillar hyperplasia clinically cysltr may blocked montelukast objective compare expression cysltr cysltr cells hyperplasic tonsils sensitized control snoring children methods sixty children years age referred adenotonsillectomy divided groups according responses skin prick test cells removed tissues stained cysltr cysltr counted via flow cytometry messenger rna mrna expression cysltrs genes measured real time quantitative reverse transcription polymerase chain reaction qpcr results group showed reduced expression small cysltr lymphocytes regarding large lymphocytes group showed lower expression cysltr cysltr cysltr lymphocytes considering total number lymphocytes group fewer cysltr lymphocytes cell populations exhibited reduced expression group without statistical significance expression cysltr significantly higher cysltr studied cell populations mrna expression show significant differences groups conclusion expression cysltr higher lymphocytes children cysltr shows greater expression cysltr respiratory allergies appear stimulus occurrence newer drugs capable blocking cysltrs warrant study ars aaoa llc
work report design development characterization analytical performances colorimetric smartphone based immunosensor detection cancer antigen immunosensor based sandwich strategy primary antibody immobilized spotting onto nitrocellulose membrane immunospots subsequently incubated solutions followed affinity reaction secondary antibody labeled gold nanoparticles aunps antibody aunps captured onto immunospots induced silver deposition silver enhancer solution leading formation gold silver nanoparticles different grey color spots depending concentration megapixels smartphone camera integrated home made dark box used transducer color image acquisition data handling pixel intensity captured images determined image processing algorithm experimental parameters involved step immunosensor design studied optimized obtaining limit detection selectivity immunoassay proven different concentration solutions vascular endothelial growth factor vegf antigen unspecific protein blank signal obtained tested solutions finally preliminary experiments human serum samples spiked protein also performed therefore proposed system could represent powerful point care tool next generation technology detecting monitoring cancer biomarkers early stages taking advantage nowadays gadgets enhanced features smartphones
dominant view self help remedy exercised individuals alternative seeking state sanctioned aid words self help consists legally permissible conduct individuals undertake absent compulsion law without assistance government official efforts prevent remedy legal wrong indeed self help often vaunted efficient least potentially efficient alternative slower costlier cumbersome civil justice system world increasingly exorbitant legal costs meaningful access civil justice system remedies initiated executed without prohibitive expense merit scholarly attention notwithstanding potential promise legal scholarship self help meagre moreover behaviour counts self help left unclear self help currently understood risks becoming meaningless term cipher almost behaviour initiated individual furtherance legal rights count selfhelp article defends narrower conception self help recommended dominant view clarifies misgivings checks hopes self help self help properly understood alternative civil justice system privilege act vis vis another certain way certain circumstances exist exercise always defeasible final determination court self help words equivalent taking law one hands implied conclusion comfort might worry extra legal nature self help ask trepidation unilateral action one individual determine scope existence rights another based article understanding self help simply conclusion however might disappoint hope self help part solution current access justice crisis true alternative civil justice system specter costly inefficient litigation adjudication remains
engineering design process consists sequence creative innovative routine design tasks routine tasks address well known procedures add limited value technical improvement product even may require lot work order focus designers work added value tasks present work aims supporting routine task design archetype captures stores reuses design knowledge tool embedded cad software algorithms drive designer selecting effective design concept deliver project requirements embody concept configuring cad model finally case study definition tool gear design demonstrates effectiveness tool
backgroundinvasive fungal infections ifis infrequent major complication heart transplantation sought describe epidemiology institution methodsa prospective cohort study heart transplant recipients performed june december ifis defined european organization research treatment cancer mycoses study group criteria resultsby univariate analysis hispanic ethnicity associated ifi odds ratio confidence interval subsequently multivariate logistic regression performed adjusting hispanic ethnicity age gender seventeen ifis identified occurring median days post interquartile range days five ifis ifis occurred hospitalization ifis first year incidence conclusionsthe cumulative incidence ifis associated pre post vancomycin resistant enterococcus colonization infection post renal replacement therapy anti thymocyte globulin induction antibody mediated rejection associations diabetes mellitus desensitization cellular rejection treatments rejection operation neutropenia cytomegalovirus infection ifis associated death year mortality year mortality associations hispanic ethnicity must validated optimal strategies risk reduction prophylaxis remain undefined
objective tower london tol planning ability task includes multiple versions original tol developed shallice together two scoring systems tol another two tol proposed anderson krikorian purpose study provide normative data four tol explore effects demographic variables tol performance furthermore aimed determine discriminative validity tol clinical samples method four groups included study normative sample healthy adults patients parkinson disease mild cognitive impairment mci without cognitive impairment patients schizophrenia sch effects demographic variables tol examined group groups comparisons tol conducted using regression analysis dummy codes results four tol significantly affected age whereas effect gender education consistent tol significantly differentiate mci sch cohen effect size coefficients range internal consistency coefficients cronbach tol range conclusions despite poor questionable internal consistency tol discriminative validity clinical utility assessing planning deficits mci sch high study provides normative standards four tol adult population use clinical practice
aim parent reporting needed examine quality life qol children cerebral palsy across severities study examines whether qol changes childhood adolescence predicts adolescent qol method sparcle european cohort study children randomly sampled population databases year olds joining study revisited year olds subject report boys girls parent reported qol occasions using kidscreen transformed rasch scale mean per domain associations assessed using linear regression results childhood adolescence average qol reduced six domains points stable three physical wellbeing autonomy social acceptance socio demographic factors little predictive value childhood qol strong predictor domains adolescent qol severe impairments motor function communication predicted higher adolescent qol domains except severe motor impairment predicted lower adolescent qol autonomy domain psychological problems higher parenting stress childhood worsening adolescence predicted lower qol five eight domains respectively contemporaneous pain seven domains final model explained variance qol depending domain interpretation general impairment severity socio demographic factors predictors lower adolescent qol however pain psychological problems parenting stress predictors lower adolescent qol domains modifiable factors addressing may improve adolescent qol elsevier ltd rights reserved
rhododendrol induced leukoderma acquired depigmentation develops mainly contact site repeated use skin whitening cosmetics containing rhododendrol cases cessation depigmentation occurrence repigmentation observed discontinuing use cosmetics however patients develop vitiligo vulgaris spread depigmentation non exposed areas study aims investigate patient specific factors may affect extent depigmentation repigmentation well development vitiligo vulgaris degree depigmentation face neck hands exposed rhododendrol scored using photographs time relationships depigmentation score first visit improvement rate depigmentation score patient demographics evaluated three important clinical observations made first repigmentation face superior compared hands neck suggesting possible role migration differentiation melanocyte stem cells hair follicles mechanism repigmentation second intensity rhododendrol exposure contribute differences severity depigmentation suggested possibility underlying genetic susceptibility melanocyte cytotoxicity immune reaction third depigmentation score first visit past history atopic dermatitis significantly high patients developed vitiligo vulgaris suggested severe chemical damage melanocytes rhododendrol leads higher risk developing vitiligo vulgaris possible involvement immune reaction clinical observations may help understand pathogenesis rhododendrol induced leukoderma
background gene regulatory network grn represents interactions genes inside cell tissue vertexes edges stand genes regulatory interactions respectively reconstruction gene regulatory networks particular genome scale networks essential comparative exploration different species mechanistic investigation biological processes currently network inference methods computationally intensive usually effective small scale tasks networks hundred genes difficult construct grns genome scale results present software package gene regulatory network reconstruction genomic level gene interaction measured conditional mutual information measurement using parallel computing framework package named cmip package greatly improved implementation previous pca cmi algorithm cmip provide automatic threshold determination method also effective parallel computing framework network inference performance tests benchmark datasets show accuracy cmip comparable current network inference methods moreover running tests synthetic datasets demonstrate cmip handle large datasets especially genome wide datasets within acceptable time period addition successful application real genomic dataset confirms practical applicability package conclusions new software package provides powerful tool genomic network reconstruction biological community software accessed http www picb cmip
background although available evidence insufficient acupuncture used patients suffering chronic asthma aim pragmatic study investigate effectiveness acupuncture addition routine care patients allergic asthma compared treatment routine care alone methods patients allergic asthma included randomized controlled trial randomized receive acupuncture sessions months control group receiving routine care alone patients consent randomization received acupuncture treatment first months followed cohort trial patients allowed receive routine care addition study treatment primary endpoint asthma quality life questionnaire aqlq range months secondary endpoints included general health related quality life short form range outcome parameters assessed baseline months results total patients mean age years female randomized included analysis patients randomized acupuncture control nonrandomized acupuncture group randomized part acupuncture associated improvement aqlq score compared control group difference acupuncture control group confidence interval well physical component scale mental component scale physical mental months treatment success maintained throughout months patients consenting randomization showed similar improvements randomized acupuncture group conclusions patients allergic asthma additional acupuncture treatment routine care associated increased disease specific health related quality life compared treatment routine care alone
paper study adjustments birth control policy population using national census data establish grey prediction model forecast total population future year compared actual data conclusion drawn birth control policy controls country population growth rate extent based grey relevant method analyze factors affecting population growth obtain age structure sex ratio two main influencing factors based two main factors conclude family planning policy impact population structure country especially accelerated ageing problem sex ratio imbalance
patients diagnosed acute traumatic spinal cord injury experience least complication hospitalization age severity neurological injury concurrent traumatic brain injury comorbid illness mechanism injury associated increasing risk complication complications occur within weeks injury complications associated sci carry significant risk morbidity mortality early identification management critical care sci patient
freeze drying technique attractive method environmental friendly cost effective shaping process preparing advanced materials interconnecting pore channels pore gradients bodies freeze drying technology kind methods build porous structural material efficiently controllably recent years many new polymer based materials prepared freeze drying exhibited broad applications functional materials article reviews progress advanced polymer materials prepared freeze drying summerizes applications field materials engineering environment biomedicine prospects research prospects directions rapidly developing field also briefly addressed
purpose study examine perception injury risk taekwondo community members taekwondo community completed online survey rated perceived risk injury across range different sports including taekwondo overall respondents perceived risk injury sport lower collision contact sports including popular combat sports boxing mixed martial arts judo karate males odds ratio instructors coaches odds ratio perceived risk injury significantly less compared female athlete counterparts behaviour determined perceived rather actual risk underestimation injury risk concomitant overestimation ability negotiate risk may lead increased frequency injury therefore comprehensive injury prevention strategy combat sports taekwondo ensure erroneous beliefs attitudes injury risk among participants addressed
determine whether encoding misleading information presented two different types leading questions closed specific open presumptive questions could disrupted participants took part misinformation experiment viewed event answering questions closed specific structure robber shotgun black barrel brown stock open presumptive structure tell shotgun half questions contained misleading information half questions participants completed concurrent distractor task finally completed recognition memory test original event results showed concurrent distractor task interview reduced size misinformation effect closed specific questions impact misinformation effect open presumptive questions results suggest open presumptive questions encourage participants encode process misleading information deeply closed specific questions misinformation effect difficult disrupt concurrent task encoding misleading information open presumptive questions closed specific questions implications interviewing discussed
paper new multi terminal active component namely current backward transconductance amplifier cbta proposed design procedure systematic realization current mode ladder filters using proposed active component also presented order demonstrate cbta considerably simplifies leapfrog structure current mode ladder filters fifth order butterworth low pass filter requires minimum active components presented theoretical results demonstrated using pspice simulation elsevier gmbh rights reserved
based taking full account building load renewable energy output characteristics cold regions multi source hybrid heat pump system mshhps seasonal thermal storage proposed seasonal thermal storage comprehensively utilized solar energy geothermal energy air energy composition operation modes system introduced mathematical model main parts proposed system established transition condition different operating modes system determined taking building harbin object simulation analysis operation effect change soil temperature field system obtained results showed average coefficient performance cop mshhps seasonal thermal storage harbin region years soil thermal balance rate energy saving rate comparing ground source heat pump system gshps initial investment mshhps required additional double source heat pump unit accounted static payback period double source heat pump unit years system maintain efficient economical operation typical cold regions elsevier ltd rights reserved
successful regeneration cranium patients suffering cranial bone defects integral step restore craniofacial function however restoration craniofacial structure challenging due complex geometry limited donor site availability poor graft integration address problems investigated use thiol acrylate hydrogel cell carrier facilitate cranial regeneration thiol acrylate hydrogels formulated poly ethylene glycol diacrylate pegda mmdithiothreitol dtt degradation rate swelling ratio shear modulus resulting hydrogel first characterized pre osteoblast like cells mcte encapsulated hydrogel cultured results demonstrate compared samples formulated pegda pegda samples showed lower storage modulus day kpa versus kpa higher weight change soaking pegda group showed weight loss day pegda group showed weight gain time period cell viability pegda dtt hydrogel decreased compared pegda dtt gel day however histological analysis cells culture revealed pericellular mineral deposition indicating cells differentiating osteoblasts lineage experimental groups study shows thiol acrylate hydrogels tailored achieve different degradation rates order enhance cell viability differentiation thus findings study provide fundamental understanding application thiol acrylate hydrogels cranial bone regeneration
previous work presented experimental theoretical evidence podophyllum derivatives substituted chlorine atom posititon aminopyridine exhibited significantly elevated potency study series podophyllum derivatives substituted position aminopyridine including methyl fluorine groups synthesized chemical structures confirmed spectral nuclear magnetic resonance nuclear magnetic resonance electrospray ionization mass spectrometry elemental analyses derivatives tested respective cytotoxicities hela bgc huh mcf cells mtt assay pharmacological results showed displayed potent cytotoxicities least one tested cancer cell lines structure activity relationship study suggested introduction fluorine atom posititon aminopyridine enhanced cytotoxicity numerous tumor cells compared chlorine atom methyl group furthermore biological experiments consistent beneficial effect fluorine atom substituent position aminopyridine inhibited microtubule polymerization activity topoisomerase amino fluoropyridine substituted podophyllotoxin demethylepipodophyllotoxin work effecting target proteins induce dependent apoptosis
sex differences chronic pain reported emerge adolescence although unclear includes responses treatment conducted meta analysis examine whether sex differences present outcome variables pretreatment whether efficacy psychological therapies pediatric chronic pain differs boys girls posttreatment follow time points searches conducted extending existing cochrane reviews randomized controlled trials examining efficacy psychological therapies chronic recurrent pain children adolescents forty six articles eligible inclusion data extracted regarding pain disability anxiety depression boys girls pretreatment posttreatment follow time points published study reported outcome data separately sex authors studies contacted studies provided data twice many girls enrolled clinical trials psychological therapies pediatric chronic pain boys girls reported higher depression anxiety pretreatment boys girls headache also reported significantly greater pretreatment pain severity treatment gains consistent across sexes one exception posttreatment disability children nonheadache pain conditions girls exhibited significant effect treatment relative control condition standardized mean difference effect observed boys standardized mean difference future research examine whether mechanisms treatment efficacy differ boys girls consider impact pretreatment sex differences response treatment
backgroundrecent research indicates evidence neuropsychological weaknesses visuospatial memory central coherence set shifting adults anorexia nervosa growing interest neuropsychological functioning patients based upon assumption neuropsychological weaknesses contribute clinical features illness however due paucity research connection neuropsychological difficulties clinical features link remains hypothetical main objective study explore association specific areas neuropsychological functioning body size estimation patients healthy controls methodsthe sample consisted women diagnosed healthy female controls participants administered continuous visual memory test recall trials rey complex figure test assess visual memory central coherence assessed using copy trial rey complex figure test wisconsin card sorting test used assess set shifting body size estimation assessed computerized morphing programme resultsthe analyses showed significant correlations neuropsychological measures body size estimation conclusionthe results suggest association areas neuropsychological difficulties body size estimation among patients copyright john wiley sons ltd eating disorders association
paper proposes continuous time framework least squares parameter estimation method evolution equations nonlinear systems standard state space representation linear unknown constant parameters investigated two estimators studied first one consists linear evolution equation second one consists impulsive linear evolution equation paper discusses theoretical aspects related proposed estimators uniqueness solution attractive equilibrium point solves unknown parameters deterministic framework estimation noisy measurements proposed using sobolev space negative index model noise noise large magnitude concrete signals issued electronic device used discuss numerical aspects elsevier ltd rights reserved
hydrogen sulfide formed human intestinal tract end product anaerobic microbial degradation sulfur compounds present mucus bile proteins since human gut microbial sulfur metabolism poorly characterized aimed identify isolate microorganisms involved sulfide formation fresh fecal samples one healthy donor one diagnosed irritable bowel syndrome used inocula enrichments supplemented sulfate sulfite electron acceptors combination different electron donors two transfers cultures high sulfide production selected phylogenetic composition enriched microbial communities determined sulfite respiration cysteine degradation dominant sulfidogenic processes abundant bacteria enriched belonged bilophila clostridium cluster xiva different isolates obtained remarkably included novel sulfite reducer designated strain strain belongs veillonellaceae family firmicutes phylum showed limited rrna gene sequence similarity known sporomusa species hence may represent novel genus study indicates bacteria utilize sulfite organic sulfur compounds rather merely sulfate relevant human intestinal sulfur metabolism
goal study evaluate potential relationship among polymorphisms aromatic hydrocarbon receptor aromatic hydrocarbon receptor repressor rheumatoid arthritis susceptibility well association among polymorphisms aromatic hydrocarbon receptor aromatic hydrocarbon receptor repressor expression performed hospital based case control study patients healthy controls han chinese populations two single nucleotide polymorphisms selected genotyping including aromatic hydrocarbon receptor aromatic hydrocarbon receptor repressor single nucleotide polymorphism statistically significantly increased risk found associated allele odds ratio confidence interval unfortunately significant differences exhibited allelic genotype frequencies groups failed find association genotypes expression patients respectively statistical relationship found aromatic hydrocarbon receptor aromatic hydrocarbon receptor repressor messenger ribonucleic acid levels clinical data either study demonstrated polymorphisms significant genetic susceptibility patients furthermore suggests allele might associated dangerous effect han chinese populations
preference based approach proposed grid computing regard preferences given various groups virtual organization stakeholders users resource owners administrators improve overall quality service resource load efficiency specific cyclic job batch scheduling scheme examined performs job flow metascheduling balancing stakeholders conflicting preferences policies two different metrics introduced find scheduling solution balanced stakeholders additionally two job batch slicing procedures proposed establish equality scheduling jobs different preferences types
herbal medicines long used treat parkinson disease systematically analyze anti parkinsonian activity echinacoside ech neurotoxic model provide future basis basic clinical investigations male cbl mice randomized blank control model ech administration groups ech significantly suppressed dopaminergic neuron loss caused mptp maintained dopamine content dopamine metabolite content compared measured mice methyl phenyl tetrahydropyridine mptp induced damage additionally ech inhibited activation microglia astrocytes substantia nigra suggested involvement neuroinflammation relevant cytokines detected proteome profiler array confirmed ech participated regulation seven cytokines given mitogenactivated protein kinase pmapk kappab kappa signals considered closely related neuroninflammation gene expression levels pmapk six kappa dna binding subunits assessed western blotting analysis showed pmapk kappa subunit upregulated mptp group ech downregulated expressions minocycline administered positive control inhibit neuroinflammation differences detected minocycline ech mediated inhibition pmapk kappa signals conclusion echinacoside potential novel orally active compound regulating neuroinflammation related signals parkinson disease may provide new prospect clinical treatment
recently relationship fracture surface roughness material strength received much attention literature paper image used novel economic tool characterize fracture surface roughness steel fiber reinforced concrete sfrc main purpose study investigate effect steel fiber content concrete design mix surface roughness direct tensile tests carried dog bone shape sfrc specimens constant size fracture surface specimens photographed fracture trajectory list pixel numbers extracted using image analysis techniques fractal dimensions calculated based box counting algorithm via computational code finally validate results applied formulations discrete fractal fracture mechanics wnuk yavari published accordingly estimation ratio quantum fracture step maximum void size given describe relationship design strength fracture roughness also steel fiber effect formation surface trajectory discussed according image analysis results correlation matrix significant parameters study presented concluded image analysis economic accessible method surface roughness characterization elsevier ltd rights reserved
firewall configuration important activity modern day business particularly critical task supervisory control data acquisition scada networks control power stations water distribution factory automation etc lack automation tools assist critical task resulted unoptimised error prone configurations expose networks cyber attacks automation make designing firewall configurations reliable deployment increasingly cost effective best practices proposed industry developing high level security policy ansi isa best practices lack specification several key aspects needed allow firewall automatically configured instance standards vague firewall management policies captured high level using specifications paper uncover missing pieces propose extensions apply extended best practice specification real world firewall case studies achieve multiple objectives evaluate usefulness refined best practice automated specification firewalls illustrate even simple cases scada networks often insecure due misconfigured firewalls
wide use geosynthetic geotechnical engineering brings great demand characterization studies material main tests known wide width strip method static puncture test cbr test tensile creep creep rupture behavior projects use geosynthetic engineering works ensure simple techniques standardized tests national international level procedure characterization quality control material becomes simplified knowing inherent difficulties wide width tensile test article proposes use non standardized test geosynthetic determine indirect tensile materials static puncture test generates good results indirect correlation result voltage article shows way test uses support static puncture test apparatus analyze indirect tensile test made narrow strip attached ends support application pressure center strip means bar main idea paper obtain results without intrinsic effects material sample punctured circular piston cbr thus get closer conventional test tensile deformation obtained first author quoted results show possible determine values stress strain test results thus making possible another way characterizing material
since eddy current problem usually depends geometry moving conductive sheet pole shape general method find analytical solution analyses eddy current rotating disk electromagnet one extended array performed case time invariant field find approximate analytical solution method solve eddy current problem firstly concept coulomb law mapping technique introduced consideration boundary condition secondly induced magnetic flux density calculated lumped way using ampere law thirdly net magnetic flux density defined introducing magnetic reynolds number ratio induced magnetic flux density applied magnetic flux density electromagnet fourthly analyses extended system extended array two electromagnets finally braking torque calculated applying lorentz force law computed result compared experimental one
composites reinforced shape memory alloy sma fiber shrinks matrix one introduce artificial compressive residual stress along direction shrinkage previous study sma fiber plaster smart composite using alloy fibers fabricated found bending strength composite improved compressive stress due shape recovery force sma fibers however imperfect bonding interface sma fiber plaster matrix decreased bending strength fabricated composite study matrix smart composites containing sma fibers studied since well known alloys react straight mass mass mass sma fibers arranged fiber holder immersed mold molten step ferrous sma reacted fiber matrix interface results good bonding strength interface solidification ferrous sma fiber matrix composite could obtained composite subjected rolling deformation induce martensitic transformation gamma austenite epsilon martensite sma fibers composite heated induce reverse transformation epsilon martensite gamma austenite ferrous sma fibers composite shrank reverse transformation could induce tensile stress fibers compressive stress matrix compressive stress matrix key factor enhances mechanical properties smart composite mechanical properties fabricated smart composites also studied
worldwide glioblastoma gbm lethal frequent intracranial tumor despite decades study overall survival gbm patients remains unchanged epidermal growth factor receptor egfr amplification gene mutation thought negatively correlated prognosis study used proteomics determine ubxn negative downstream regulator egfr mutation viii egfrviii via bioinformatics analysis found ubxn factor improve glioma patients overall survival time also determined regulation ubxn mediated upregulation hkme presence egfrviii kappa negatively regulated ubxn believe egfrwt viii activates kappa suppressing ubxn expression importantly used latest genomic editing tool crispr cas knockout egfrwt viii exon proved ubxn negatively regulated egfrwt viii furthermore knockout egfr egfrviii could benefit gbm vitro vivo indicating crispr cas promising therapeutic strategy egfr amplification egfr mutation bearing patients elsevier ireland ltd rights reserved
paper deals initial boundary value problem following one dimensional two fluid system element alpha alpha alpha alpha represent respectively gas mass liquid mass corresponding fluid velocities whereas alpha alpha volume fractions occupied gas liquid phase pressures associated model represents submodel full two fluid model studied bresch important difference model studied present work studied bresch viscosity coefficients assumed constant bresch assumed mass dependent coefficients allowed derive called inequality implies masses since excluded following route instead explore use two non equal pressure functions equal allows obtain global estimates guarantee stability result hold prove tilde tilde infinity respect norm infinity constant states tilde tilde estimates time asymptotic behavior also provided elsevier ltd rights reserved
associations preference violent electronic games adolescents self perceptions problem behaviors emotions examined predicted preference violent games would associated negative externalizing characteristics particular aggressive emotions behaviors youth self report ysr standardized self report measure adolescent problem behaviors thirty two year olds girls listed categorized favorite electronic games one six predetermined categories completed ysr manova revealed significant relationships preference violent games thought problems subscale ysr total score trends noted internalizing anxious depressed subscales expected relationships externalizing behaviors including aggression found however across ysr subscales children higher preference violent games clinically significant elevations low preference violent games total problems subscale eight children receiving scores clinically significant range six high preference group three boys three girls failure rind expected relationships preference violent games aggressive externalizing behaviors puzzling possible individuals preference violent games may high exposure forms media violence perceptions behavior comparison may seem sufficiently aggressive justify endorsement problems area playing violent electronic games may promote disconnection emotions normally associated violence violent acts explanations consistent desensitization model exposure media violence decreases sensitivity aggression wiley liss inc
article presents automatic generation control unequal three area thermal system single stage reheat turbines generation rate constraints min considered control area controllers integral proportional integral proportional integral derivative pid proportional integral derivative plus second order derivative pid treated secondary controllers separately nature inspired optimization technique called ant lion optimizer alo algorithm used simultaneous optimization controller gains comparison dynamic responses frequencies tie line powers corresponding alo optimized pid pid controller reveal better performance pid controller terms lesser settling time peak overshoots well reduced oscillations robustness optimum gains best controller obtained nominal conditions evaluated using sensitivity analysis analysis exposed optimum pid controller gains obtained nominal robust necessary reset changes loading parameter like inertia constant size position disturbance furthermore performance pid controller found better compared pid controller random loading pattern condition elsevier ltd rights reserved
aim study aimed evaluate accuracy imaging measurement length ileocolic segment affected crohn disease method fifty four consecutive patients underwent resection ileocolic crohn disease prospectively studied preoperative enterography two independent radiologists measured length diseased intestinal segment measurements compared length disease assessed pathology non fixed surgical specimen results median preoperative length crohn disease segment imaging measured two radiologists interobserver agreement substantial kappa correlation coefficient median length crohn disease segment pathological examination closely correlated radiological measurement length crohn disease segment imaging correct within value pathology correct patients underestimated overestimated length disease less found imaging patients confirmed pathology whereas length found imaging patients confirmed pathology sensitivity specificity positive predictive value negative predictive value overall accuracy imaging predicting length less conclusion imaging accurately identifies length ileocolic segment crohn disease less pathological examination patients extensive disease imaging tends overestimate length interpreted caution
paper presents work carried authors apply intel mkl pardiso parallel sparse matrix solver load flow solution algorithms matpower opendss goal explore potential execution time reduction obtained working large power systems multi core installations test systems different sizes solved order observe time reduction function system size number cores used parallel execution results show except full newton raphson algorithm one expect reduction execution times using parallel routine use parallel sparse matrix solver justified sparse matrix must recalculated every step solution process systems study much larger analyzed paper also presents parallel computing solution implemented different applications using available high performance parallel libraries
image coaddition one basic operations astronomers perform paper presented optimal ways coadd images order detect faint sources perform flux measurements assumption noise approximately gaussian build results derive first principles coaddition technique optimal hypothesis testing measurement source detection flux shape measurements star galaxy separation background noise dominated case method several important properties pixels resulting coadded image uncorrelated image preserves information original individual images spatial frequencies hypothesis testing measurement done individual images simultaneously done coadded image without loss information psf image typically narrow narrower psf best image ensemble moreover image practically indistinguishable regular single image meaning code measures property regular astronomical image applied unchanged particular optimal source detection statistic derived paper reproduced matched filtering image psf coaddition process call proper coaddition understood maximum signal noise ratio measurement fourier transform image weighted way noise entire fourier domain equal variance method important implications multi epoch seeinglimited deep surveys weak lensing galaxy shape measurements diffraction limited imaging via speckle observations last topic covered depth future papers provide implementation algorithm matlab
paper presents investigation current state practice manufacturing engineering discipline concurrent manufacturing planning research adopted case study approach conducted globally operating manufacturer aerospace products investigation establishes information systems cross functional teaming enable integrated processes planning manufacturing method progress simultaneously design lean efficient manner applies value stream analysis understand value non value added transactional processes
paper presents activity concerning modeling control innovative power assisted electric bicycle proposed control method based torque control designed via optimal approach achieve multi objective performances regarding external disturbance input control signal magnitude velocity tracking error performance methodology evaluated applying proposed control new pedelec pedal electric cycle model characterized measurement total torque rider torque electric motor one employed feedback control aim mathematical model bicycle equipped electric motor developed simulations performed order evaluate tracking capability disturbance rejection performances compared ones referred traditional assistance approach results demonstrate proposed approach provides improvements terms riding comfort energy employment
several methods based port payload transport layer features proposed detect identify manage internet traffic diminished effectiveness port based identification overheads deep packet inspection methods motivated identify internet traffic combining distinctive flow characteristics machine learning method however abundant ground truth internet traffic important building supervised classifier difficult obtained real conditions study propose semi supervised learning method combines division recognition space technique data gravitation theory division recognition space classifier powerful multi classification tool helpful multi application identification data gravitation may reveal underlying data space structure unlabeled data thus integrated classification develop better classifier experimental results real internet application traffic datasets demonstrate advantages proposed work
purpose growing body evidence suggests low testosterone independent predictor adverse clinicopathological features worse prognosis prostate cancer pca patients however association still incompletely understood results divisive aim study analyze testosterone predictor aggressive disease subjects clinically localized pca materials methods cohort conducted including patients submitted radical prostatectomy institution period four years patients clinically localized disease total testosterone routinely measured pre operatively morning surgery stratified groups low tumor aggressiveness inferred based preoperative psa levels pathological gleason score lower equal greater tnm stage surgical margins status results analyzing patients found significant association mean preoperative extraprostatic disease conversely men high gleason score similar mean compared lower scores preoperative low defined could statistically correlated either preoperative psa levels pathological gleason score extraprostatic extension positive surgical margins seminal vesicles involvement conclusions study indicates testosterone may useful predictive tool pathological extraprostatic extension somewhat signaled lower levels preoperatively however consolidate clear association aggressive tumor biology hypogonadism
indian saint bahinabai became known anglophone audience largely ramanujan well known essay women saints ramanujan notes bahinabai life diverges standard trajectory hindu women saints insofar reject husband family however external conformity rules women contrasts literary subversion normative gender roles examine bahinabai autobiographical narrative atmacharitra demonstrate claims spiritual rights women undermining brahmanical ideal devoted wife pativrata rare example pre modern women writing south asia atmacharitra illustrates diverse strategies indian women employed circumvent strictures feminine self expression
paper segmentation based approach fine registration multispectral multitemporal high resolution vhr images proposed proposed approach aims estimating correcting residual local misalignment also referred registration noise often affects multitemporal vhr images even standard registration method extracts automatically set object representative points associated regions homogeneous spectral properties objects scene points result distributed considered scene account high spatial correlation pixels vhr images estimates amount direction residual local misalignment object representative point exploiting residual local misalignment properties multiple displacement analysis framework end multiscale differential analysis multispectral difference image employed modeling statistical distribution pixels affected residual misalignment pixels detect used perform segmentation based fine registration based temporal spatial correlation accordingly method particularly suitable used images large number border regions like vhr images urban scenes experimental results obtained simulated real multitemporal vhr images confirm effectiveness proposed method
orc represents effective challenge waste heat recovery ices spite technological aspects thermodynamic design still deserves attention mixtures pure fluids show interesting properties able improve exergetic efficiency rankine cycle thanks positive slope phase changing reduce also odp gwp helping replacement trends working fluids paper optimizes cycle exergetic efficiency considering mixtures pure fluids use hydrocarbons mixtures particularly suitable used limited fractions organic fluids loses limits related flammability rfa fluid obtains large net power increase used mixtures hydrocarbons compared pure fluid optimized rfa benzene mixture instance attains net power increase published elsevier ltd
recently homozygous mutations desmoglein dsg gene heterozygous mutation desmoplakin dsp gene demonstrated associated severe dermatitis multiple allergies metabolic wasting sam syndrome mendelian inheritance man aim identify molecular basis chinese pedigree sam syndrome chinese pedigree sam syndrome subjected mutation detection dsg gene sequence analysis dsg gene quantitative reverse transcriptase polymerase chain reaction analysis gene expression dsg using cdna derived epidermis patients controls performed skin biopsies also taken patients pathological study transmission electron microscopy observation novel homozygous splicing mutation delg exon intron border dsg gene demonstrated associated sam syndrome report new family sam syndrome asian decent expand spectrum mutations dsg gene
non steroidal anti inflammatory drugs diclofenac naproxen widely used treatment arthritis ankylosing spondylitis acute muscle pain however usually metabolized simply pass human body drugs difficult decomposed general waste treatment strategies caused serious environmental concerns report rapid efficient conversion diclofenac naproxen chloroperoxidase catalyzed oxidation heme protein isolated caldarimyces fumago complete conversion diclofenac naproxen achieved min respectively mmol nanomolar enzyme concentration converted products identified hplc nmr suggesting involvement multiple steps cpo catalyzed conversion work demonstrated cpo treatment cod removal diclofenac naproxen respectively followed existing bioremediation technologies activated sludge greatly improved decontaminating two drugs waste water cod removal enhanced respectively eco toxicity evaluation according value using green algae chlorella pyrenoidos ecological indicators showed converted products diclofenac naproxen lower toxicity original drugs elsevier rights reserved
introduction nephrotic syndrome known cause hypothyroidism however effect replacement doses thyroxine patients primary hypothyroidism systematically studied aim aim present study evaluate effect newly diagnosed nephrotic syndrome dose thyroxine replacement previously diagnosed patients primary hypothyroidism full stable dose thyroxine replacement least one year materials methods patients previously diagnosed primary hypothyroidism stable full day replacement dose thyroxine least one year developed newly diagnosed nephrotic syndrome included study patients evaluated thyroid function tests diagnosis every months replacement doses thyroxine titrated single endocrinologist based serum thyroid stimulating hormone tsh level results study included nine patients mean age years significant increase tsh diagnosis nephrotic syndrome compared immediate past visit needed increase replacement dose thyroxine last follow four patients remission nephrotic syndrome thyroid function tests improved reduction replacement dose thyroxine whereas patients achieve remission required increase thyroxine dose conclusion development nephrotic syndrome significantly increases need thyroxine replacement dose previously diagnosed primary hypothyroidism patients full stable dose thyroxine replacement
novel reconfigurable lowpass polyphase biquad filter based mfb structure proposed paper biquad one amp adopted improves matching reduces power consumption transmission function synthesized complex signal flow graph order filter used zigbee transceiver implemented illustrate technique realized cmos technology avoid variation resistance capacitance chip tuning scheme integrated test results show polyphase mode centered mhz mhz bandwidth image rejection voltage gain lowpass mode cut frequency mhz gain band order input intercept point iip dbm polyphase mode dbm lowpass mode attractively filter consumes power supply occupies area
transcription factor myb involved control cell proliferation survival differentiation processes accompany morphogenesis developing teeth work investigates possible role myb odontogenesis analysis expression myb monophyodont mouse followed similar analysis diphyodont species pig dentition closely resembling human distribution myb correlated pattern proliferation apoptosis tooth phenotype myb mutant mice also assessed mouse myb expression detected throughout prenatal development first molar tooth negative temporospatial correlation found myb expression apoptosis myb expression positively correlated proliferation myb positive cells however abundant proliferating cell nuclear antigen positive cells suggesting roles myb odontogenesis minipig contrast mouse asymmetrical arrangement myb positive cells higher presence labial side tooth germ dental lamina cluster negative cells situated mesenchyme close tooth bud later stages number positive cells decreased cells situated upper part dental papilla areas future cusp formation expression myb species strong odontoblasts ameloblasts stage dentin enamel production suggesting possible novel role myb tooth mineralization
large holes unavoidably generated depth image based rendering dibr using single color image associated depth map holes mainly caused disocclusion occurs around sharp depth discontinuities depth map propose divide conquer hole filling method refines background depth pixels around sharp depth discontinuities address disocclusion problem firstly disocclusion region detected according degree depth discontinuity target area marked binary mask depth pixels located target area modified linear interpolation process whose pixel values decrease foreground depth value background depth value finally order remove isolated depth pixels median filtering adopted refine depth map ways disocclusion regions synthesized view divided several small holes dibr easily filled image inpainting experimental results demonstrate proposed method effectively improve quality synthesized view subjectively objectively
traveling recommendation systems become popular applications organizing planning tourist trips among challenges applications faced task maintaining updated information popular tourist destinations well providing useful tourist guides meet users preferences work present plantour system creates personalized tourist plans using human generated information gathered minube traveling social network system follows automated planning approach generate multiple day plan relevant points interest city region visited particularly system collects information users points interest minube groups points clustering techniques split problem per day sub problems uses shelf domain independent automated planner finds good quality tourist plans unlike tourist recommender systems plantour planner able organize relevant points interest taking account user expected drives user scores real social network paper also highlights use human provided recommendations guide search solutions combinatorial tasks resulting intelligent system opens new possibilities combining human generated knowledge efficient automated techniques solving hard computational tasks engineering perspective advocate use declarative representations problem solving tasks shown improve modeling maintenance intelligent systems elsevier ltd rights reserved
emetophobia researched disorder characterized specific fear vomiting paucity research impairing condition extant examinations largely limited adult samples online communities present study examined incidence phenomenology correlates emetophobia salvadorian youths caregivers completed battery questionnaires regarding youth symptoms emetophobia internalizing externalizing symptoms health anxiety obsessive compulsive symptoms approximately sample elevated emetophobia symptoms higher levels emetophobia symptoms correlated higher levels internalizing externalizing health anxiety obsessive compulsive symptoms lower levels adaptive functioning youths meeting cutoff elevated emetophobia symptoms versus demonstrated significantly higher levels externalizing behaviors well general obsessive compulsive symptoms especially doubting checking neutralizing behaviors findings hoped help improve conceptualization treatment poorly understood disorder
next generation sequencing technologies afforded unprecedented characterization low frequency rare genetic variation due low power single variant testing aggregative methods commonly used combine observed rare variation within single gene causal variation may also aggregate across multiple genes within relevant biomolecular pathways kernel machine regression adaptive testing methods aggregative rare variant association testing demonstrated powerful approaches pathway level analysis although methods tend computationally intensive high variant dimensionality require access complete data additional analytical issue scans large pathway definition sets multiple testing correction gene set definitions may exhibit substantial genic overlap impact resultant correlation test statistics type error rate control large agnostic gene set scans fully explored herein first outline statistical strategy aggregative rare variant analysis using component gene level linear kernel score test summary statistics well derive simple estimators effective number tests family wise error rate control conduct extensive simulation studies characterize behavior approach relative direct application kernel adaptive methods variety conditions also apply method two case control studies respectively evaluating rare variation hereditary prostate cancer schizophrenia finally provide open source code public use facilitate easy application methods existing rare variant analysis results
article describes brief treatment mexican american teenager presented family therapy address major depressive disorder mdd comorbid binge purge behaviors treatment brief integrated components family based therapy legrange narrative therapy overarching multicultural lens progress measured self report children depression inventory parent report concrete behavioral markers reduced number purging events end treatment reduction depressive symptoms elimination suicidal ideation cutting behaviors reduction fatigue anhedonia low mood well disrupted eating behaviors supporting teenager family identify leverage individual family strengths treatment also strengthened family communication increased shared positive family experiences family meals supported teenager engaging community activities consistent family values case adds existing literature reviewing ways treatment modified across multiple domains provide culturally sensitive care well identifying weaknesses approach may serve illuminate gaps existing literature highlight areas clinicians may want adapt treatment strengthen client outcomes
background mood disorders constitute high burden patients society notwithstanding large arsenal available treatment options considerable group patients remit current antidepressant treatment urgent need develop alternative treatment strategies recently low strength transcranial pulsed electromagnetic field tpemf stimulation purported promising strategy treatment resistant depression trd mode action new technique however largely unknown methods searched pubmed literature reports effects tpemf information regarding working mechanism biological substrate results studies less connect major hypotheses depression concern effects tpemf brain metabolism neuronal connectivity brain plasticity immune system relatively studies paid attention possible chronobiologic effects electromagnetic fields limitations reviewed literature new still developing field reports involved translational studies inevitably limits reach conclusions conclusion weak magnetic fields influence divergent neurobiological processes antidepressant effect tpemf may specifically attributable effects local brain activity connectivity elsevier inc rights reserved
alemtuzumab humanized monoclonal antibody targeting surface molecule resulting rapid depletion innate adaptive immune cells infection rates multiple sclerosis treatment trials higher alemtuzumab interferon beta treated patients report two patients developed cytomegalovirus disease within month first day cycle alemtuzumab upon identification appropriate treatment infection recovered completely neurologists aware serious treatable complication
hydrological connectivity describes physical coupling linkages different elements within landscape regarding sub surface flows firm understanding hydrological connectivity important catchment management applications example habitat species protection flood resistance resilience improvement thinking geomorphological systems networks lead new insights also recognized within scientific community seeing recent increase use network graph theory within geosciences network theory supports analysis understanding complex systems providing data structures modelling objects linkages versatile toolbox quantitatively appraise network structure properties objective study characterize quantify overland flow connectivity dynamics hillslopes humid sub mediterranean environment using combination high resolution digital terrain models overland flow sensors network approach results showed significant differences overland flow connectivity agricultural areas semi natural shrubs areas significant positive correlations connectivity precipitation characteristics found significant negative correlations connectivity soil moisture found likely soil water repellency soil surface crusting combination structural networks dynamic networks determining potential connectivity actual connectivity proved powerful tool analysing overland flow connectivity copyright john wiley sons ltd
numerical modelling thin structures combined history dependent material large deformation challenging traditional methods analysis material point method mpm continuum represented material points lagrangian eulerian procedure suited granular material geomechanical simulations releasing process geocontainers within barge simulated split barge modelled via boundary particles prescribed angular velocity various frictional contact coefficients barge geotextile material considered moreover influence adding wrinkles bottom container follows practice evaluated predictions compared non slack geotextile effect soil properties geotextile forces also examined elsevier ltd rights reserved
paper describes accurate fault location algorithm based sequence current distribution factors double circuit transmission system proposed method uses voltage current collected local end single circuit method virtually independent fault resistance mutual coupling effect caused zero sequence current adjacent parallel circuit insensitive variation source impedance fault distance determined solving forth order kvl kirchhoffs voltage law based distance equation zero sequence current adjacent circuit estimated using zero sequence current distribution factor zero sequence current self circuit thousands fault simulation emtp proved accuracy effectiveness proposed algorithm
impact antidiabetic drugs bone metabolism drawing increasing attention due discovery correlation type diabetes mellitus tdm osteoporosis glucagon like peptide glp receptor agonists novel promising class drugs tdm may also clinical applications bone tissue disorders review examines impact glp bone metabolism including enhancement bone mineral density improvement bone quality however precise effect glp fracture risk unambiguously defined review also summarizes current understanding mechanisms glp affects bone metabolism glp may act bone promoting bone formation inhibiting bone resorption affecting coordination two processes describe molecular pathways proteins wnt calcitonin associated glp bone tissue specific processes related molecular mechanisms effects glp bone metabolism need explored clarified
aim objectives backgroundchronic hepatitis chc virus infection leading cause liver related morbidity mortality germany many countries lack comprehensive epidemiological data routine data sickness funds support estimation true prevalence incidence chc methodsin article results annual quarterly analyses prevalence incidence years presented using data several german sickness funds resultsoverall prevalence rate remained relatively stable lower general assumption germany conclusionwe found despite introduction breakthrough designated triple therapies telaprevir boceprevir increase prevalence incidence copyright wolters kluwer health inc rights reserved
paper applies ecological modernization framework analyze china green building program focuses effective institutionalization environmental objectives respective political economic systems thus provides valuable insights roles state stake holders environmental regulation since mid chinese government advanced aggressive green building campaign distinguished speed scale evolution one voluntary participation top implementation administrative hierarchies resulted remarkable growth green building projects questions remain effectiveness sustainability state centered approach though interviews officials planners architects real estate developers property managers several chinese cities data analysis green building stock surveys architects paper analyzes chinese green building patterns situates patterns among contradictory motivations different levels government relationships different stake holders research finds top state apparatus sufficient overcome contradictions profit motives property developers however many underdeveloped opportunities exist leverage property developers building professionals public engage green building practices end argue state must embrace reform build flexible collaborative movements parties strong public participation china ecological modernization process may feature stronger state faster changes exempted need political modernization elsevier ltd rights reserved
despite expansion early intervention approaches young children asd investigators struggled identify measures capable assessing social communication change response interventions addressing recent calls efficient sensitive reliable social communication measures current paper outlines refinement validation social communication checklist scc discuss two small studies exploring psychometric properties scc scc revised social communication checklist including sensitivity change inter rater reliability test retest reliability two samples children asd one sample typically developing children results indicate measure reliable sensitive change brief social communication intervention strongly related well established measures social communicative functioning
several scanning probe microscopy spm techniques scanning tunnelling microscopy stm conductive atomic force microscopy afm rely precise measurements current flowing investigated sample conductive nanoprobe parameters current voltage converter cvc detect current picompere range utmost importance systems determine microscopes measuring capabilities motivation research precise current integrator pci described paper could used cvc afm systems main design goal pci provide small versatile device sub picoampere level resolution high dynamic range order nanoamperes pci based integrating amplifier texas instruments ddc paired stmf microcontroller unit mcu gain bandwidth pci might easily changed varying integration time feedback capacitance depending parameters possible obtain example resolution range khz bandwidth resolution range bandwidth measurement sinusoidal current amplitude also presented pci integrated afm system used highly ordered pyrolytic graphite hopg graphene samples imaging
photodegradation polycyclic aromatic hydrocarbons pahs may important degradation pathway pahs regions high solar radiation present investigation aimed studying photodegradation pahs deposition surface soils different textures photodegradation products also identified semi quantified well correlated decrease parent compounds experiment performed deploying soil samples spiked mixture epa priority pahs methacrylate box exposed solar radiation days meaning solar energy hypoth esized individual pahs volatilized sorbed photodegraded depending physicochemical properties well soil characteristics low medium molecular weight pahs sorbed photodegraded fine textured regosol soil higher volatilization observed coarse textured arenosol soil contrast high molecular weight pahs photodegraded arenosol soil specially low half lives noted anthracene benzo pyrene agreeing previous findings laboratory scale nine products identified including oxy nitro hydro pahs whose toxic mutagenic potential might higher priority pahs
non relational databases recently preferred choice comes dealing bigdata challenges performance sensitive chosen data organisations seen differences times response time query different models brings users need fully conscious queries intend serve order design data model common practice replicate data different models designed fit different query requirements scenario user charge code implementation required keep consistency different data replicas propose design mechanism prototype provide users transparent management queries matched well performing model option additionally propose transforming replication mechanism heterogeneous replication one order avoid squandering disk space keeping availability reliability features
hardware accelerator presented compute probabilistic inference bayesian network distributed sensing applications energy efficiency accelerator operated near threshold voltage achieving maximum clock frequency mhz clique tree message passing algorithm leveraged compute probabilistic inference theoretical maximum size factor proposed hardware accelerator handle entries sufficient handling massive bns pathfinder munin nodes logical alarm reduction mechanism alarm used benchmark performance accelerator accelerator consumes execute alarm network using clique tree message passing algorithm algorithm executed ultralow power microcontroller consumes
rectangular plate modeling roadway suspension bridge considered contributions bending stretching energies analyzed latter plays important role due presence free edges linear model first considered case separation variables used determine explicitly deformation plate terms vertical load moreover method allows study spectrum linear operator least eigenvalue stretching energy introduced without linearization equation becomes quasilinear nonlinear term also affects boundary conditions consider two quasilinear models surface increment model sim stretching energy proportional increment surface nonlocal model nlm introduced berger see berger sim nlm studied detail according strength prestressing prove existence multiple equilibrium positions elsevier ltd rights reserved
notion asymmetric quantum dialogue aqd introduced conventional protocols quantum dialogue essentially symmetric users alice bob encode amount classical information contrast proposed scheme aqd provides different amount communication powers alice bob proposed scheme offers architecture entangled state used encoding scheme shared alice bob depend amount classical information want exchange general structure aqd scheme obtained using group theoretic structure operators introduced shukla phys lett effect different types noises amplitude damping phase damping noise proposed scheme investigated shown proposed scheme aqd robust uses optimized amount quantum resources
store operated calcium entry soce universal calcium influx mechanism expressed several different cell types known stromal interaction molecule stim sensor intracellular compartments together orai transient receptor potential canonical trpc subunits permeable channels plasma membrane cooperate regulating multiple cellular functions diverse proliferation differentiation migration gene expression many others depending cell type particular growing body evidences suggests tight control soce expression function achieved megakaryocytes along route hematopoietic stem cells platelet production review attempts provide overview soce dynamics megakaryocyte development focus recent findings related involvement physiological pathological thrombopoiesis
thyroid hormones ths triiodothyronine thyroxine essential embryonic development vertebrates vertebrate embryos exposed ths maternal origin maternal levels known essential embryonic development natural variation maternal ths probably represents pathway maternal effects modify offspring phenotype however potential fitness consequences variation maternal exposure within normal physiological range without confounding effects mother never experimentally investigated experimentally manipulated levels yolk within physiological range species embryo develops outside mother body rock pigeon columba livia eggs making use natural difference yolk testosterone two eggs pigeon clutches also able investigate potential interaction ths testosterone elevated yolk levels enhanced embryonic development hatching success reduced body mass tarsus length day fledging yolk hormones increased plasma concentrations females reduced males line effect metabolic rate hatching plasma concentrations testosterone significantly affected effects treatment differ eggs high low testosterone levels data indicate natural variation maternal yolk levels affects offspring phenotype embryonic survival potentially influencing maternal chick fitness elsevier inc rights reserved
study examined effects display curvature flat display zone zones task duration min legibility visual fatigue participant completed two min visual search task sets curvature setting settings yielded better results flat setting terms legibility perceived visual fatigue relative corresponding centre zone outermost zones flat settings showed decrease legibility whereas flat setting showed increase perceived visual fatigue across curvatures legibility decreased whereas perceived visual fatigue increased second task set two task sets induced increase eye complaint score decrease critical fusion frequency indicated increase visual fatigue summary curvature around central display zones frequent breaks recommended improve legibility reduce visual fatigue elsevier ltd rights reserved
one important considerations designing clinical infant research studies selection reliable valid measurement procedures measures caregiver child interactions studied newborns particularly premature infants main objective study examine psychometric properties national institute child health human development nichd mother child interaction qualitative ratings sample premature infants mothers evaluate use neonatal intensive care unit mother baby dyads videotaped min interaction nicu nine raters independently assessed dyadic interactions using nichd mother child interaction qualitative ratings fully crossed research design rater reliability strong mother infant ratings scores yielded normal distributions maternal sensitivity positive regard flatness affect skewed distributions maternal intrusiveness detachment negative regard child ratings positive maternal behaviors correlated positively one another negatively negative maternal behaviors thus preliminary analyses suggest scores obtained using nichd mother child interaction qualitative ratings premature babies mothers neonatal intensive care unit demonstrate adequate interrater reliability distributional properties provide preliminary evidence face validity
many big data applications usually categorized irregular irregular problems feature unpredictable unstructured properties terms program flow data access pattern typically use pointer based data structures graphs problems data compute communication intensive nature algorithms therefore designed implemented high performance architectures first stage parallel algorithm design data partitioning stage data sub divided equally sized disjoint elements communication volume among processors minimized data represented graph stated graph partitioning problem hard work consider metaheuristic ant brooding algorithm based larval sorting ants solve graph partitioning problem parallel ant brooding algorithm implemented cluster using mit julia language test parallel algorithm different benchmark synthetic graphs compare julia parallel implementation julia sequential sequential implementations found performance julia comparable good scalability parallel julia implementation achieves speedup greater synthetic graph vertices edges
paper geothermal based multi generation energy system including organic rankine cycle domestic water heater absorption refrigeration cycle proton exchange membrane electrolyzer developed generate electricity heating cooling hydrogen purpose energetic exergetic exergoeconomic analysis undertaken upon proposed system also effects important variables geothermal water temperature turbine inlet temperature pressure generator temperature geothermal water mass flow rate electrolyzer current density several parameters energy exergy efficiencies proposed system heating cooling load net electrical output power hydrogen production unit cost system products total unit cost products investigated specified conditions results show energy exergy efficiencies proposed multigeneration system calculated respectively highest lowest total unit cost products estimated approximately respectively considering geothermal water temperature increases degrees degrees published elsevier ltd
although patients diabetes times increased risk cardiovascular morbidity mortality individuals without diabetes recent studies indicate significant part patients lower cardiovascular risk category men younger years women younger years patients diabetes duration less years without risk factors much lower risk patients traditional cardiovascular risk factors subclinical established coronary artery disease cad patients risk equivalent stated previous studies contrary presence traditional risk factors evidence subclinical coronary disease high coronary calcium score coronary risk much increased patients may classified higher risk category recent guidelines anymore consider diabetes cad risk equivalent recommend cardiovascular risk stratification primary prevention stratification diabetic patients improves accuracy prediction subclinical cad silent ischemia future cardiovascular events stratification also discriminates higher lower risk patients may need intensive statin aspirin prevention avoiding overtreatment lower risk cases may also allow clinician decide whether intensify risk reduction actions specific newer drugs glucose control sglt inhibitors glp agonists recently shown additional cardiovascular protector effect review addresses assessment cardiovascular disease risk using traditional non traditional cardiovascular risk factors also reviews use risk calculators new reclassification tools focusing detection subclinical atherosclerosis well silent ischemia asymptomatic patients diabetes
study displacement blocking force tip point cantilevered electro active polymer eap actuator controlled cell injection process consists approaching interacting leaving steps vision based system used acquire tip displacement data identifying transfer function model actuator position control discrete time proportional integral controllers used control position blocking force smith predictor utilized vision based position control system compensate time delay due image processing experimental position blocking force results prove proposed control strategies effective enough guide actuator undertake cell injection process study contributes previously published work point view simultaneously controlling position blocking force electroactive polymer actuators widening application areas
genomics assisted breeding methods rapidly developed novel technologies next generation sequencing genomic selection genomewide association study however phenotyping still time consuming serious bottleneck genomics assisted breeding study established highthroughput phenotyping system sorghum plant height response nitrogen availability system relies use unmanned aerial vehicle uav remote sensing either rgb near infrared green blue nir camera evaluated potential remote sensing provide phenotype training data genomic prediction model uav remote sensing nir camera percentile digital surface model indicator height performed well correlation coefficient plant height measured uav remote sensing phuav plant height measured ruler phr phuav overestimated probably presence taller plants adjacent plots correlation coefficient phuav phr increased using one two replications lower phuav value genomic prediction modeling performed well low fertilization condition probably phuav overestimation smaller condition due lower plant height predicted values phuav phr highly correlated result suggests genomic prediction models generated phuav almost identical performance uav remote sensing similar traditional measurements genomic prediction modeling uav remote sensing high potential increase throughput phenotyping decrease cost uav remote sensing important indispensable tool high throughput genomics assisted plant breeding
conditions experienced individuals prenatal development long term effects phenotype maternally transmitted resources important mediators prenatal effects potential interactive effects among shaping offspring phenotype never studied maternally derived testosterone known stimulate growth benefits may counterbalanced increase production reactive oxygen species ros maternally transmitted carotenoids might capacity scavenge ros thereby buffer increase oxidative stress caused prenatal exposure high testosterone levels experimentally tested interactive effects maternal yolk testosterone carotenoid japanese quail coturnix japonica found hatching mass reduced reactive oxygen metabolites roms levels end period maximal growth increased chicks eggs injected either testosterone carotenoid tendency chicks testosterone injected eggs however egg compounds manipulated simultaneously hatching mass rom levels affected showing carotenoid testosterone lose detrimental effects ratio compounds balanced study provides first experimental evidence interactive effects maternally derived egg compounds offspring phenotype suggests developmental cues tightly coadjusted within egg
background many patients report adverse reactions may tolerate statin therapy patients may increased risk coronary heart disease chd events mortality objectives study evaluated risk recurrent myocardial infarction chd events cause mortality medicare beneficiaries statin intolerance high adherence statin therapy methods studied medicare beneficiaries began moderate high intensity statin dosage hospitalization statin intolerance defined titrating statins initiating ezetimibe therapy switching statins ezetimibe monotherapy international classification diseases revision diagnostic codes rhabdomyolysis antihyperlipidemic adverse event followed statin titration discontinuation switching types statins within year initiation high statin adherence year following hospital discharge defined proportion days covered recurrent chd events recurrent coronary revascularization procedure mortality identified year hospital discharge december results overall patients statin intolerance patients high statin adherence median years follow recurrent mis chd events deaths compared beneficiaries high statin adherence statin intolerance associated higher rate recurrent per person years respectively higher rate chd events per person years respectively lower rate cause mortality per person years respectively multivariate adjusted hazard ratios comparing beneficiaries statin intolerance versus high statin adherence confidence interval recurrent chd events cause mortality conclusions statin intolerance associated increased risk recurrent chd events cause mortality coll cardiol american college cardiology foundation
biotechnological applications enzymes limited due activity stability trade implies increase activity accompanied concomitant decrease protein stability premise based thermally adapted homologous enzymes cold adapted enzymes show high intrinsic activity linked enhanced thermolability contrast thermophilic enzymes show low activity around ambient temperatures nevertheless genetically chemically modified enzymes beginning show activity stability trade overcome review origin activity stability trade thermodynamic basis enhanced activity stability various approaches escaping activity stability trade discussed role entropy enhancing activity stability enzymes highlighted special emphasis placed involvement solvent water molecules review concluded suggestions research underscores implications findings context productivity curves daniel danson equilibrium model catalytic antibodies life cold planets
maxima free open source computer algebra system perform symbolic computations solving equations determining derivatives functions obtaining taylor series manipulating algebraic expressions article present maxima bridge system collection software programs allows stata interface maxima maxima used symbolic computation transfer data stata maxima retrieve results maxima cooperation stata maxima provides environment statistical analysis symbolic computation easily used together facilities supplied stata environment symbolic computation algorithms used manage complexity algebra calculus whereas numerical computation used speed matters also discuss software architecture maxima bridge system present several examples illustrate develop new stata commands exploit capabilities maxima
objective opioids suppress gonadal hormone production may result low testosterone levels date large scale population based studies examining extent opioid use may contribute changes testosterone levels design cross sectional study setting national health nutrition examination survey subjects participants years older data prescription medication usage serum testosterone levels available participants divided two groups opioid exposed unexposed methods testosterone levels participants responded exposed prescription opioids past days compared unexposed number participants low testosterone levels calculated unadjusted adjusted analyses performed results participants opioids higher odds low testosterone levels unexposed odd ratio confidence interval controlling opioid exposure age number comorbidities increased odds low testosterone levels significantly increased categories compared participants years age participants years compared participants comorbidities participants comorbidities conclusion assessing impact opioids testosterone effects age medical conditions considered
paper addresses effectiveness geocell mattress prepared waste plastic bottles fly ash filling material overlying soft clay bed laboratory model tests test beds subjected loading means square rigid steel plate footing effect height width geocell mattress well basal bamboo geogrid underneath geocell mattress overall performance system terms footing pressure settlement adjacent surface deformation heave settlement systematically studied series tests test results indicate around twofold increases bearing pressure placing jute geotextile separator beneath unreinforced fly ash bed whereas reinforcing fly ash bed geocell mattress presence basal bamboo geogrid jute geotextile separator produce sevenfold increases footing pressure inclusion basal bamboo geogrid improves overall behavior reinforced bed surface deformation occurred unreinforced beds inclusion geocell mattress improves footing pressure creates surface deformation heave settlement increase height well width geocell mattress diminishes surface heaving also increases footing pressure present study carries limitation boundary scale effects quantitative results must extrapolated dimensional analysis use practical applications field study required however qualitative results encourage use waste plastic bottles soft ground improvement turn may solve disposal issue certain extent american society civil engineers
contradictory results found literature concerning fungi bacteria pet exposure risk developing asthma allergens thoroughly studied separately cohort studies variety sampling analytical methods used already possible characterize fungi mites bacteria qpcr aim study evaluate qpcr systems quantify presence cats dogs homes twenty four houses sampled electrostatic dust collector analyzed qpcr questionnaires presence pets homes completed results qpcr correlated real presence cats dogs highlighted indirect exposure study provides useful screening tool used future large cohort studies elfe cohort study
crohn disease inflammatory chronic bowel disorder involve whole gastrointestinal tract localization ileum colon common reference standard diagnosis ileocolonoscopy histologic assessment reference standard detection complications surgery however imaging techniques important role detection localization follow patients last years technical development ultrasound equipment advent new technologies elastography mostly increased expertise sonographers boosted role bowel ultrasound assessment gastrointestinal tract fact bowel ultrasound particularly attractive thanks widespread availability non invasiveness low cost good reproducibility easily repeated follow aim article provide extensive overview actual role bowel ultrasound detection follow patients published elsevier inc behalf world federation ultrasound medicine biology
background adolescents sleep duration subjective psychological well related however studies examined relationship sleep duration subjective psychological well longitudinally across adolescence time profound biological psychosocial change aim longitudinal study investigate whether shorter sleep duration adolescents predictive lower subjective psychological well months months later whether lower subjective psychological well predictive shorter sleep duration methods adolescents age range years mean age years female german speaking switzerland norway reported sleep duration subjective psychological well school days using self rating questionnaires baseline months months baseline results cross sectional longitudinal analyses revealed sleep duration decreased age longer sleep duration concurrently associated better subjective psychological well crossed lagged autoregressive longitudinal panel analysis showed sleep duration prospectively predicted subjective psychological well evidence reverse relationship conclusion sleep duration predictive subjective psychological well findings offer support importance healthy sleep patterns adolescence
background aims nutritional therapy first line approach treatment hyperlipidemia childhood proprotein convertase subtilisin kexin type pcsk key regulator plasma cholesterol levels target novel lipid lowering pharmacotherapies examined effects intensive nutritional intervention pcsk levels overweight adolescents cardiovascular disease cvd risk factors methods results twenty seven obese overweight adolescents cvd risk factors assigned either low fat low glycemic load diet week intensive phase assigned meals delivered home participants received weekly person home nutrition counseling phone calls subjects underwent month maintenance phase without food provision person contact anthropometric measurements laboratory data serum pcsk protein levels measured baseline weeks months pcsk decreased weeks pcsk levels returned baseline levels months maintenance phase change pcsk associated change fasting insulin homa auc insulin independent weight loss conclusions pcsk decreased youth participating intensive dietary intervention change homa associated change pcsk independent weight loss suggesting important relationship insulin sensitivity italian society diabetology italian society study atherosclerosis italian society human nutrition department clinical medicine surgery federico university published elsevier rights reserved
low component sensitivity band pass filter proposed filter one operational amplifier active component three resistors one grounded capacitor passive components two resistors provide positive feedback one resistor used independent tuning factor capacitor grounded advantage integrated technology circuit uses pole frequency operational amplifier working operated high frequency range pspice simulations presented verify theoretical analysis
goa petcoke consultancy services provides comprehensive consultancy services solutions field petroleum coke calcination course working various assignments probed fundamental principles design rotary kiln systems petcoke calcination resulting evolution paper important process criteria calciner design retention time heating rate operating drafts factors depend kiln dimensions slope heat transfer rate air injections understand well worked mass heat balance across kiln cooler incinerator mechanical design consider load factors thermal expansions strength materials elevated temperatures ensure mechanical soundness protection flexing distortion kiln shell refractory design take account differential thermal expansion coefficients ability withstand high temperatures resistance spalling chemical attack abrasion good coatability
article reviews effects restrictive eating disorders bone health relationship eating disorders amenorrhea discussed detail pathologic impact malnutrition bone explored examining results studies using various available imaging techniques multiple hormonal alterations seen adolescents young women anorexia nervosa reviewed well alterations may influence bone turnover density structure strength diagnostic clinical evaluation adolescents young women disorders also outlined available treatment options including hold promise efficacy well deemed ineffective considered clinical mechanistic standpoints finally future research opportunities offered including intriguing work area fat bone interactions
digital world every one seeks information internet time passed every one placed digital content web web website developers support place data relational databases databases different organizations agencies available online accessible web query interfaces web query interfaces act front door access information relational databases web forms web query interfaces need human intervention submit form data order make search engines capable accessing relational databases data behind query interfaces query generation done automatically paper discuss different form submission techniques fetch data databases propose novel technique dynamic query processing hidden web data extraction
order investigate rounding process high precision centerless grinding time domain reliably predictably virtual machine design approach essential particularly towards roundness precision virtual machine system presented paper developed high level integration machine characteristics workpiece rounding mechanism intrinsic correlation system primary elements affecting workpiece roundness regeneration including kinematics dynamics control machine grinding dynamics machining conditions integrated high precision virtual centerless grinding render rounding process evaluate machine performance optimize grinding strategies accordingly application case study virtual machining targeted workpiece roundness provided present implementation perspectives virtual machine system high precision centerless grinding
background incidence spinal epidural hematoma seh estimated per patients per year seh classified idiopathic spontaneous secondary cause spontaneous seh uncertain may associated minor trauma seh compress surrounding structures shown clinical symptoms signs affect spinal cord nerve roots surgical treatment may considered medical treatment fails case description year old man presented lower back pain significant radicular symptoms left side week denied previous lumbar trauma use anticoagulation drugs used full endoscopic transforaminal approach extraforaminal technique remove seh local anesthesia patient discharged home days surgery radicular pain disappeared completely three months later follow magnetic resonance imaging showed dark brown lesion totally removed conclusions spontaneous sehs uncommon although lumbar laminectomy mainstream treatment neurologic deficits caused epidural hematomas percutaneous full endoscopic transforaminal approach may option certain sehs
theory suggests activation pain concepts memory increases subsequent pain perception previously researchers found activating pain concepts memory increases pain perception subsequent painful stimuli relative neutral information however attempted quantify nature association information studied ensuing pain perception subliminally presented words either low high degree association word pain although partially successful words consciously perceived participants received randomized laser heat stimuli delivered intensity levels low moderate high measured effect behavioral electrophysiological measures pain participants rated moderate high intensity laser stimuli painful viewing high relative low associates pain effects remained present controlled measures mood anxiety physical symptom reporting similar effects observed physiologically higher stimulus negativity preceding high relative low associates greater amplitudes component laser evoked potential presentation high associates moderate high laser intensity conditions data support activation based models effects memory pain perception perspective consistent current theories memory pain found high relative low activation pain concepts memory increased psychological physiological responses laser induced pain effect remained regardless whether participants showed conscious awareness activation theoretical clinical implications discussed american pain society
background cognitive factors might link early attachment experiences later depression similar cognitive vulnerability factors discussed relevant unipolar bipolar disorders goals study test differences concerning attachment style cognitive factors remitted unipolar bipolar patients compared controls test association attachment style depressive symptoms mediated cognitive factors methods path model tested participants remitted unipolar remitted bipolar disorder healthy subjects adult attachment insecurity hypothesized affect subsyndromal depressive symptoms partial mediation dysfunctional attitudes self esteem results differences patients remitted unipolar bipolar disorders concerning attachment style dysfunctional attitudes self esteem subsyndromal depressive symptoms found groups reported dysfunctional pattern healthy controls path models confirmed relationship attachment style depressive symptoms mediated cognitive variables dysfunctional attitudes self esteem limitations cross sectional nature study results explain causal development time conclusions results emphasize relevance elaborate understanding cognitive interpersonal factors mood disorders important address cognitive biases interpersonal experiences treatment mood disorders
article showcases case study cloud computing model combined mega microcontrollers educational purposes presented system takes advantage many aspects internet things model thus conjoining cloud management system measurement execution module based arduino platform one benefit solution cost effective way showcasing machine device integration distinct cloud services article based practical experience students projects home alarm system use cloud computing services described
radiopharmaceuticals containing motive tripeptide arginyl glycyl asparatic acid rgd known target alpha beta integrins tumor angiogenesis generic kit radiolabeling procedure accommodating different generators developed nota rgd evaluated versatile use safety subsequent vivo applications nota rgd kit verified expected biodistribution pharmacokinetics nonhuman primates clinical sensitivity detect solitary pulmonary nodules spn cancer patients single vial kits containing nmol nota cyclo arg gly asp tyr lys nota rgd sodium acetate trihydrate buffer formulated versatility nota rgd radiolabeling performance adaption tio sno based generator type characterization long term storage stability kits carried blood clearance urine recovery kinetics well image guided biodistribution nota rgd studied vervet monkey model nota rgd kits tested clinically target solitary pulmonary nodules kits could successfully formulated warranting integrity months good nota rgd radiolabeling performance radiochemical purity decay corrected yield specific activity gbq mol kits met quality requirements tested vivo nota rgd cleared rapidly blood majorly excreted via renal route liver spleen heart intestines showed initial uptake steadily declining tissue activity concentration time addition nota rgd kit allowed delineation spn non malignant lung tissue humans versatile radiolabeling procedure using kit formulated nota rgd different generator types achieved uncompromised vivo behavior efficient targeting spn warrants investigations clinical relevance nota rgd derivatives implement initial guidelines management patients regard integrin targeted imaging
developing programming education support tool pgtracer utilizing fill blank questions pgtracer operates moodle provides questions student parts masked pair program trace table question consists four xml files representing program trace table two types masks program trace table propose teacher function pgtracer paper question editing data analysis functions question editing function includes automatic generation function xml files representing program trace table given source program input data pgtracer collects student log provides data analysis function various viewpoints student question
identifying prognostic factors remission early rheumatoid arthritis era patients key clinical importance studied patient reported outcomes pros predictors remission clinical trial randomized untreated era patients receive remission targeted treatment three disease modifying antirheumatic drugs prednisolone months infliximab placebo initial months baseline measured following pros eight short form questionnaire dimensions patient global assessment pga visual analogue scale vas health assessment questionnaire haq pain vas used multivariable adjusted regression models identify pros independently predicted modified american college rheumatology remission years follow data years available patients patients remission baseline patients achieved remission higher radiological score lower tender joint count lower pga physician global assessment lower haq less morning stiffness significantly higher scores seven eight dimensions compared patients multivariable models included pros remission associated dimensions higher vitality odds ratio confidence interval better emotional role functioning odds ratio confidence interval pga pain vas haq dimensions associated remission conclude self reported vitality better emotional role functioning among important pros prediction remission era
industrialization buildings could make great contributions housing demand prefabrication modular construction factories assembling within job site could increase quality project implementation reduce project time side building information modeling bim could hired effective efficient tool within construction industry therefore incorporation bim industrialization buildings could improve strengths weaknesses industrialization process addresses design integration construction improved efficient management capability phases study role building information modeling bim industrialization buildings interactions investigated authors published elsevier ltd
drawing upon social cognitive domain theory self determination theory goal present multi informant study test whether correlates maternal prohibitions depend prohibited content social domain involved thereby contrasting moral friendship prohibitions well prohibition communicated thereby contrasting autonomy supportive controlling communication style sample adolescents mean age years female mothers mean age years first examined mean level differences two domains terms mothers degree style prohibition well number developmental outcomes adolescents legitimacy perceptions internalization oppositional defiance adolescents mothers reported maternal involvement moral domain higher scores degree prohibition controlling communication style addition adolescents reported greater perceived legitimacy less oppositional defiance moral domain compared friendships domain second tested whether associations degree style prohibition developmental outcomes moderated social domain whereas associations degree prohibition developmental outcomes either non significant moderated domain associations communication style domain invariant autonomy supportive style generally yielding adaptive pattern correlates controlling style relating maladaptive outcomes discussion focuses similarities differences characteristics correlates types prohibitions
oxford family planning association contraceptive study includes women initially aged years recruited british family planning centers interval subsequently followed periods years article examines pattern referral hospital back disorders among women certain back disorders reported occur frequently oral contraceptive users women back pain also reported women consequent using intrauterine device disorders considered spinal osteoarthritis displaced cervical disc displaced lumbar disc unspecified displaced disc cervicalgia unspecified back pain sprains strains back spinal osteoarthritis unspecified backache two conditions significantly related positively age displaced lumbar disc unspecified displaced disc strongly positively related height weight unspecified backache showed similar less striking terms magnitude relative risks associations height weight little evidence found association oral contraceptive use back disorders true intrauterine device use contraception elsevier science inc rights reserved
geotextiles increasingly applied reinforcement road embankments soft soil purpose study determine optimum tensile strength geotextile reinforcement road embankment considering allowable factor safety displacement stability analysis road embankment done finite element method using plaxis study three types sequence modeling conducted first stability road embankment without reinforcement analyzed second modeling determine length geotextile reinforcement considering stability model road embankment last sequence investigate stability model reinforced embankment various tensile strength geotextiles reinforcement result study showed optimum tensile strength geotextiles strongly influenced factor safety authors published elsevier ltd
suspension bridges good spanning ability seismic resistance avoid need tall piers reduce amount foundation excavation therefore suspension bridges first choice building large span bridges recent expansion highways high mountainous region western china led widespread construction large span suspension bridges mountainous areas deep canyons feature complex topographic geological conditions constricted construction sites extensive unloading rock masses problematic stability high steep slopes adversely affect foundation stability complicate surveys analyses paper aizhai suspension bridge used case study four key issues related bridge foundation stability analyzed results suggest comprehensive geological investigation needed develop full understanding geological conditions particularly unloading dissolution related geologic defects rock masses stability problem bridge foundation rock masses occurs primarily high steep slopes banks canyon design load cause significant deformation rock mass proper reinforcement measures taken ensure stability slope rock mass foundation rock mass stable addition significant interaction observed structures tunnel type anchorage resist strong pullout forces via clamping effect provided surrounding rock tunnel type anchorages rarely used rock mechanics surrounding rocks fully studied therefore pullout capacity anchorages may seriously underestimated elsevier rights reserved
backgroundschools address critical sexual reproductive health srh issues among youth however little known srh education implemented charter schools thus purpose explore implementation srh education charter schools methodsusing purposive sampling semistructured telephone interviews conducted charter school principals san diego county california questions guided kaiser family foundation national survey public secondary school principals analyses followed case oriented approach examining aspects within case principal comparative analysis small number cases principals resultsoverall principals acknowledged offering sexuality education previous years half schools provided content sexually transmitted diseases human immunodeficiency virus acquired immune deficiency syndrome stds hiv aids reproduction pregnancy birth pregnancy prevention methods delaying sex managing sexual pressure condom use sexual assault sexual orientation talking partners std pregnancy prevention talking parents relationships sex using get contraception less commonly taught abortion addressed asked grade would assign schools sexuality hiv instruction principals assigned conclusionsconsistency findings reported elsewhere varies charter schools often greater curricular flexibility traditional schools study provides unique preliminary data inform future innovative strengthen existing srh programming
common way deal uncertainty present noisy sensorial perception action model problem probabilistic framework maximum likelihood estimation well known estimation method used many robotic computer vision applications gaussian assumption maximum likelihood estimation converts nonlinear least squares problem efficient solutions nonlinear least squares exist based iteratively solving sparse linear systems convergence general existing solutions provide estimation mean state vector resulting covariance computationally expensive recover nevertheless many simultaneous localization mapping slam applications knowing mean vector enough data association obtaining reduced state representations active decisions next best view applications require fast state covariance recovery furthermore computer vision robotic applications general performed online case state updated recomputed every step size continuously growing therefore estimation process may become highly computationally demanding paper introduces general framework incremental maximum likelihood estimation called slam fully benefits incremental nature online applications provides efficient estimation mean covariance estimate based propose strategy maintaining sparse scalable state representation large scale mapping uses information theory measures integrate informative non redundant contributions state representation slam differs existing implementations performing matrix operations blocks led extremely fast matrix manipulation arithmetic operations used nonlinear least squares even though paper tests slam efficiency slam problems applicability remains general
experiment investigated effects violent content video games two physiological indicators fight flight response cortisol cardiovascular changes accessibility aggressive thoughts children participants played randomly assigned violent nonviolent video game rated game several dimensions word completion task results showed violent video game increased cortisol boys cardiovascular arousal relative baseline equally exciting nonviolent game violent game also increased accessibility aggressive thoughts cortisol findings particular suggest playing violent video game may activate sympathetic nervous system elicit fight flight type response children theoretical implications future research discussed elsevier ltd rights reserved
introduction neuropsychiatric symptoms nps alzheimer disease associated significant negative outcomes patients caregivers agitation one distressing nps lacks safe effective long term interventions nonpharmacological interventions suggested first line treatment effective every patient resulting pharmacological interventions patients consisting label use antipsychotics sedative hypnotics anxiolytics acetylcholinesterase inhibitors memantine antidepressants efficacy necessarily outweigh associated risks areas covered gains understanding neurobiological mechanisms underlying agitation fueled several recent clinical trials article updates review published comprehensive literature search published articles january december evaluating pharmacologic interventions agitation done review several clinical trials completed dextromethorphan quinidine scyllo inositol brexpiprazole prazosin cannabinoids citalopram escitalopram pimavanserin iti orm show promise treating agitation expert opinion neurobiological findings innovative trials designs statistical approaches preliminary paths regulatory agency acceptance ignited area pharmacological treatment nps though research needed fully determine safety tolerability efficacy treatments mission find effective treatments neuropsychiatric symptoms agitation patients dementia well underway
background study aimed establish changes incidence characteristics iodine induced hyperthyroidism hyper iodine induced hypothyroidism hypo two year period year period increase mandatory salt iodization previous potassium iodide furthermore aim determine duration treatment hyper patients since data regarding severity treatment hyper respect iodine supply available methods retrospective study reviewed medical records slovenian patients first diagnosed hyper hypo thyroid department university medical centre ljubljana hyper hypo diagnosed one senior internal medicine specialists diagnosis based adequate patient history laboratory measurements thyrotropin thyroid hormones thyroid antibodies cases thyroid ultrasound thyroid scintigraphy performed demographic characteristics type duration treatment also reviewed results incidence hypo significantly higher increase iodine supply increase iodine supply incidence hyper significantly lower increase furthermore portion patients overt hyperthyroidism decreased predominantly due increased proportion patients subclinical hyperthyroidism respectively duration treatment antithyroid drugs perchlorate significantly shorter increase iodine supply respectively significantly positive correlation year occurrence excessive iodine intake eii induced thyroid disease duration treatment amiodarone found suggesting longer patients adequate iodine supply longer could take amiodarone eii induced thyroid disorder developed conclusions increase iodine supply higher incidence hypo lower incidence hyper observed increase less severe hyper shorter duration treatment hyper well longer thyroid disease free period patients amiodarone additional beneficial clinical consequences establishment adequate iodine supply
present study aims investigate shimmy stability behavior single wheeled nose landing gear system system supposed equipped electromechanical actuator capable control shimmy vibrations proportional integrative derivative pid controller tuned using particle swarm optimization pso procedure proposed actively damp shimmy vibration time history results test cases reported commented stochastic analysis last presented assess robustness control system
accurate analysis flow transient important safety evaluation nuclear power plant study analysis vvvver reactor investigated order perform analysis model developed simulate coupled kinetics thermal hydraulics reactor simple accurate numerical algorithm thermal hydraulic calculations four equation drift flux model applied based multi channel approach core divided regions region different characteristics represented single fuel pin associated coolant channel obtain core power distribution point kinetic equations different feedback effects utilized appropriate initial boundary conditions considered two situations decreasing coolant flow rate protected unprotected core analyzed addition analysis normal operation condition full range thermal hydraulic parameters obtained transients finally data obtained model compared calculations conducted using relap mod code bushehr nuclear power plant data shown model provide accurate predictions steady state transient conditions
review examines synthesis properties acid reactivity transition metal dinitrogen complexes bearing phosphine ligands containing pendant amine groups second coordination sphere synthesized non precious metal dinitrogen complexes containing bidentate tridentate tetradentate phosphine ligands generate derived ammonia hydrazine presence excess acid metal identity metal oxidation state ligand denticity functional groups phosphorus nitrogen play role controlling site protonation metal pendant amine coordinated dinitrogen addition exogenous acid authors published elsevier rights reserved
longitudinal links early childhood temperament maternal sensitivity adolescents adjustment proposed found several longitudinal studies mechanisms influence explored authors examined paths maternal sensitivity temperament early childhood adolescents prosocial aggressive delinquent behaviors via childhood social behaviors peer group affiliation data months grade age grade age grade age nichd seccyd longitudinal investigation participants boys analyzed overall results yielded evidence maternal sensitivity child temperament months age predicted prosocial aggressive delinquent outcomes age affiliation peer groups especially prosocial peers social behaviors childhood mediated aforementioned paths effortful control maternal sensitivity discussion focuses implications understanding long term effects early childhood predictors behavioral outcomes adolescence
article various deferred rendering algorithms investigated classification formalizes comparison popular rendering techniques introduced classification consists measuring functions used determine expected algorithm performance various situations multiple analysis spaces defined better express strengths weaknesses algorithm given abundance deferred rendering methods performance tradeoffs implied different hardware targets rendered objects complexity light setup complexity framework makes choosing modifying algorithm collection simpler process following spaces used algorithm examination comparison gpu commands processing cost allocated memory expected bandwidth consumption furthermore analysis spaces independent illumination model suitable decoupled examination stage rendering process usually executed different sampling rate
consider problem design implement communication efficient versions parallel kernel support vector machines widely used classifier statistical machine learning distributed memory clusters supercomputers main computational bottleneck training phase statistical model built input data set prior study parallel isoefficiency state art implementation scaled omega problem size number processors scaling worse even one dimensional block row dense matrix vector multiplication omega study considers series algorithmic refinements leading ultimately communication avoiding svm method improves isoefficiency nearly omega evaluate methods processors show average speedups average dis smo percent weak scaling efficiency six real world datasets modest losses overall classification accuracy source code downloaded
introduction non melanoma skin cancers nmsc mainly comprise two different entities basal cell carcinoma bcc squamous cell carcinoma scc beneath two entities merkel cell carcinoma adnexal tumors dermatofibrosarcoma protuberans angiosarcoma cutaneous lymphoma belong nmsc rare skin tumors topic review bcc scc common cancers diagnosed humans preferred treatment surgery cases curative although high recurrence rate seen cancers rarely metastasize therefore systemic treatments priority patients long known abnormal activation hedgehog epidermal growth factor receptor pathways involved bcc scc last decade metastatic disease became important area research mostly new therapies targeted components two pathways became available areas covered cover available therapeutic options patients diagnosed bcc scc focus systemic targeted therapies expert opinion bcc scc common cancers good prognosis metastatic disease advanced local disease recurrent disease pose clinicians great challenge albeit promising results targeted therapies resistance development already described
perovskite solar cells emerging one promising candidates solar energy harvesting date high performance perovskite solar cells exclusively employed organic hole transporting materials htms tetrakis methoxyphenylamine spirobifluorene spiro ometad polytriarylamine ptaa often expensive low hole mobility almost htms reported needed lithium salt lithium bis trifluoromethylsulfonyl imide tfsi doping improve hole mobility performance however use tfsi avoided hygroscopic nature tfsi could cause decomposition perovskite reduce device stability herein employed solution processed cuin cigsse nanocrystals novel inorganic htm perovskite solar cells power conversion efficiency obtained cigsse based devices improved stability compared devices using spiro ometad htm work offers promising candidate based inorganic htm efficient stable perovskite solar cells
currently effective treatment acute exacerbation idiopathic pulmonary fibrosis ipf herein report case patient acute exacerbation ipf treated nintedanib intracellular inhibitor tyrosine kinases showed improvement condition year old man ipf admitted hospital dry cough worsening dyspnoea within last month presented hypoxemia chest high resolution computed tomography hrct revealed new bilateral multifocal ground glass opacities superimposed background lung fibrosis exclusion alternative causes acute exacerbation ipf diagnosed started treatment nintedanib day resulted gradual improvement condition hrct findings without administering antibiotics corticosteroids serum krebs von den lungen surfactant protein levels increased acute exacerbation subsequently decreased case suggests nintedanib therapy may possible benefits acute exacerbation ipf
diabetes salivary gland dysfunction major factors induce dental caries experimental animals reports analyzing association dental caries salivary glands animal model diabetes mellitus clarify initial development dental caries preceding salivary gland disorder performed histopathological analysis teeth salivary glands diabetic wistar rats weeks alloxan treatment group comparison nondiabetic rats non group functional analysis saliva secretion experimental period pilocarpine induced salivary fluid secretion diabetic rats gradually decreased continuous hyperglycemia immediately alloxan treatment time autopsy histopathologically oil red positive lipid droplets accumulated acinar cells parotid gland tooth stereoscopically defined dental caries rats either group however external appearance remarkably changed owing occlusal wear almost molars group initial lesions dental caries appearing micro defects dentin bacterial colonization molar surface identified using histopathological analysis incidence group twice non group conclusion hyperglycemia simultaneously induces initial caries development enhances spontaneous occlusal wear molar teeth wistar rats weeks alloxan treatment parotid gland dysfunction caused hyperglycemia may mostly involved pathogenesis occlusal wear well dental caries diabetic model
various metabolic diseases induced eating disorders serious difficult problems modern public healthcare however little known hyperphagia partly lack clear definition several basic studies analyzed eating habits using endocrinological neurophysiological approaches suggested controlled balance hunger satiety centers central nervous system however detailed neuro radiologic evaluations achieved hypothalamus evaluations limited floor third ventricles fine structures hypothalamic morphology investigated using high resolution magnetic resonance imaging seven patients hypothalamo pituitary tumors suffered preoperative hyperphagia induced severe obesity metabolic disorders body mass index bmi varied mean clinical data compared data nine patients without hyperphagia seven healthy volunteers morphological evaluation possible patients control subjects patients hyperphagia significantly shortened maximum distances ependymal layers lateral wall third ventricle fornixes hyperphagia group right side left side patients without hyperphagia group right side left side healthy group right side left side two patients achieved postoperative improvement clinical neuro radiological findings eating metabolic disorders related strong dysfunction medial nuclei hypothalamus patients hypothalamo pituitary tumors report first case dynamic improvement hyperphagia symptomatic neuro radiological findings
myer quatman khoury wall hewett youth versus adult weightlifting injuries presenting united states emergency rooms accidental versus nonaccidental injury mechanisms strength cond res resistance training previously purported unsafe ineffective children purpose investigation evaluate resistance training related injuries presenting emergency rooms age type mechanism injury hypothesized older athletes would sustain greater percentages joint sprains muscle strains whereas younger athletes would sustain greater percentage accidental injuries would result increased percentage fractures youths consumer product safety commission cpsc national electronic injury surveillance system queried using cpsc code weightlifting subjects ages grouped age categories elementary middle school age high school college adult injuries classified accidental caused dropped weight improper equipment use multiple logistic regression used compare accidental injuries age groups sample consisted patients accidental injuries decreased years years conversely sprain strain injuries increased successive age group evaluation nonaccidental injuries showed oldest categories demonstrated greater percentage sprains strains relative younger age categories two thirds injuries sustained group hand foot often related dropping pinching injury descriptions increased percentage fractures group relative groups study findings indicate children lower risk resistance training related joint sprains muscle strains adults majority youth resistance training injuries result accidents potentially preventable increased supervision stricter safety guidelines
portal hypertension clinical syndrome defined portal venous pressure exceeds mmhg cirrhosis common cause portal hypertension thrombosis splenoportal axis associated liver cirrhosis second cause portal hypertension western world primary myeloproliferative disorders main cause portal venous thrombosis somatic mutation janus kinase gene jak found approximately polycythemia vera essential thrombocyrosis primary myelofibrosis year old man jak mutation associated splenoportal axis hypertension bleeding complications due oesophageal varices reported massive upper bleeding episode made emergent surgery done immediatelly seventh day patient discharged home fifteenth day surgery author published elsevier ltd behalf ijs publishing group ltd
vascular mechanics assessed two dimensional speckle tracking echocardiography ste could used new imaging surrogate vascular stiffening cha vasc score considered accurate estimate stroke risk non valvular although many potential stroke risk factors included scoring method purpose research study feasibility evaluating vascular mechanics descending aorta non valvular patients using transesophageal ste analyze association descending aortic mechanics stroke prospectively recruited group patients referred transesophageal echocardiogram tee context cardioversion non valvular short axis view descending aorta one two centimeters aortic arch selected vascular mechanics assessment ste methodology vascular mechanics parameters analyzed circumferential aortic strain cas early circumferential aortic strain rate casr clinical assessment performed focus past stroke history cha vasc score mean age cohort years men known years considered paroxystic cases waveforms adequate measuring ste present descending aortic wall segments mean cas mean casr inter intra observer variability aortic mechanics considered adequate median cha vasc score score increased noted cas casr decreased patients past history stroke patients lower values descending aortic strain strain rate cas remained independently associated past history stroke adjustment cha vasc score data showed non valvular patients past history stroke lower values aortic mechanics assessed transesophageal ste
last years computational capabilities smart mobile devices continuously improved hardware vendors raising new opportunities mobile application engineers mobile augmented reality one scenario demonstrating smart mobile applications becoming increasingly mature area augmented reality engine application project developed kernel enables location based mobile augmented reality applications top kernel mobile application developers easily realize individual applications kernel turn focuses robustness high performance addition provides flexible architecture fosters development individual location based mobile augmented reality applications first stage project locationview concept developed core realizing kernel algorithms locationview concept proven usefulness context various applications running ios android windows phone due evolution computational capabilities one hand emerging demands location based mobile applications developed new kernel concept particular new kernel allows handling points interests poi clusters enables use tracks changes required new concepts presented paper demonstrate applicability kernel apply context various mobile applications result mobile augmented reality applications could run present mobile operating systems effectively realized engineers utilizing approach regard applications good example using mobile computational capabilities efficiently order support mobile users everyday life properly authors published elsevier
background graph based hierarchical clustering algorithms become prohibitively costly execution time storage space number nodes approaches order millions objective fast highly memory efficient markov clustering algorithm proposed perform classification huge sparse networks using ordinary personal computer methods improvements compared previous versions achieved adequately chosen data structures facilitate efficient handling symmetric sparse matrices clustering performed two stages initial connected network processed sparse matrix breaks isolated small relatively dense subgraphs processed separately convergence obtained intelligent stopping criterion also proposed quit processing subgraph tends toward completeness equal edge weights main advantage algorithm necessary number iterations separately decided graph node results proposed algorithm tested using scop large synthetic protein sequence data sets validation process revealed proposed method reduce times processing time huge sequence networks compared previous markov clustering solutions without losing anything partition quality conclusions one million node one billion edge protein sequence network defined blast similarity matrix processed upper class personal computer minutes improvement speed possible via parallel data processing extension toward several million nodes needs intermediary data storage example solid state drives elsevier ireland ltd rights reserved
age associated changes cardiac structure function together estrogen loss contribute progression heart failure preserved ejection fraction older women investigate effects aging estrogen loss development precursor asymptomatic left ventricular diastolic dysfunction echocardiograms performed middle aged months old aged months female fischerxbrown norway rats weeks ovariectomy ovx sham procedures gonads left intact cardioprotective potential administering chronic selective agonist new protein coupled estrogen receptor gper evaluated old rats old ovx versus age matched vehicle treated ovx gonadal intact rats advanced age estrogen loss led decreases myocardial relaxation elevations filling pressure part due reductions phosphorylated phospholamban increases cardiac collagen deposition eight weeks protein coupled estrogen receptor activation old ovx rats reversed adverse effects age estrogen loss myocardial relaxation increases sarcoplasmic reticulum atpase expression reductions interstitial fibrosis findings may explain preponderance heart failure preserved ejection fraction older postmenopausal women provide promising late life therapeutic target reverse halt progression left ventricular diastolic dysfunction
solar steam generation highly promising technology harvesting solar energy desalination water purification introduce novel bilayered structure composed wood graphene oxide highly efficient solar steam generation layer deposited microporous wood provides broad optical absorption high photothermal conversion resulting rapid increase temperature liquid surface hand wood serves thermal insulator confine photothermal heat evaporative surface facilitate efficient transport water bulk photothermally active space owing tailored bilayer structure optimal thermo optical properties individual components wood composite structure exhibited solar thermal efficiency similar simulated solar excitation power density novel composite structure demonstrated highly scalable cost efficient making attractive material various applications involving large light absorption photothermal conversion heat localization
sumatriptan used acute treatment migraine attacks many similarities migraine epilepsy medications used treat one disorders effectively used treat purpose study evaluate compare anticonvulsant effects sumatriptan sodium valproate nmri mice male nmri mice divided groups groups consisted saline control group intraperitoneally administered sumatriptan groups sodium valproate groups min injection either saline one drug doses pentylenetetrazol injected seizure parameters evaluated results showed sodium valproate markedly inhibited seizure stage whereas none sumatriptan doses significant effect parameter latency stages seizures interval pentylenetetrazol injection death significantly increased sodium valproate sumatriptan sumatriptan commonly used treatment migraine also protective effect seizures induced pentylenetetrazol mice
voters infer candidates political orientations faces report evidence observers make systematic judgment errors ascribing political views attractive competent looking candidates subjects judged headshot images student candidates running university elections experiment well professional politicians state election races germany experiment according whether person displayed held ideologically leftist rightist views prediction accuracy chance level experiments candidate attractiveness experiment perceived competence experiment increased subject likelihood attributing political views candidate findings suggest value face based inferences choosing candidate best represents one views limited previously assumed also suggest good looks may help extremist candidates presenting moderate
myeloproliferative disorders rare cause focal segmental glomerulosclerosis fsgs although mechanism unclear hydroxyurea commonly used disorders cytoreductive properties however effect treatment proteinuria kidney function remains unclear cases myeloproliferative disorder associated fsgs describe clinical course patient polycythemia vera nephrotic range proteinuria demonstrated fsgs biopsy patient distant history granulomatosis polyangiitis wegener routinely kidney function proteinuria measured allowing early detection nephrotic syndrome soon diagnosed polycythemia vera treatment hydroxyurea resulted rapid improvement proteinuria correlated decrease hematocrit response replicated additional times patient taken restarted hydroxyurea therapy maintains steady dose hydroxyurea favorable kidney measures proteinuria protein excretion serum creatinine corresponding estimated glomerular filtration rate min case suggests early screening treatment myeloproliferative disorder associated fsgs may lead improved long standing kidney function national kidney foundation inc
tracking controller proposed crane attached mobile harbor equipped dual stage trolley system dynamically position container container ship vice versa wave induced motions container ship occur loading unloading operations owing external disturbances waves however challenging task move payload unwanted swing motions accurately loading unloading positions moving target vessel solve problem dynamic crane model derived three dimensional space roll pitch heave motions caused sea wave disturbances crane model linearized design tracking controller parameters linearized model obtained carrying system identification process preview tracking control method includes feedback feed forward control predicted target position plane near future utilized numerical simulations experiments scaled model tracking performance proposed dynamic positioning control system considered sinusoidal roll pitch motions generated mimic wavy sea environment
compositionality property natural language prime importance enables humans form conceptualize potentially novel complex ideas combining words hand symbol grounding problem examines way meaning anchored entities external language sensory percepts sensory motor routines paper aim towards exploration intersection compositionality symbol grounding thus propose methodology constructing empirically derived models grounded meaning afford composition grounded semantics illustrate methodology case adjectival modifiers grounded models adjectively modified unmodified colors acquired specially designed procedure participants computational models modifiers dark light derived generalization ability learnt models quantitatively evaluated usage demonstrated real world physical humanoid robot regard important step towards extending empirical approaches symbol grounding accommodate compositionality necessary step towards deep understanding natural language situated embodied agents sensor enabled ambient intelligence interactive robots
paper proposes nonparametric variable step size least mean absolute third nvslmat algorithm improve capability adaptive filtering algorithm impulsive noise types noise step size nvslmat obtained using instantaneous value current error estimate posterior error estimate approach different traditional method nonparametric variance estimate nvslmat algorithm fewer parameters need set thereby reducing complexity considerably additionally mean additive noise necessarily equal zero proposed algorithm addition mean convergence steady state mean square deviation nvslmat algorithm derived computational complexity nvslmat analyzed theoretically furthermore experimental results system identification applications presented illustrate principle efficiency nvslmat algorithm
increasing stress urban water demand led exploration potential rainwater use water recycling promote sustainable water resources management rainwater harvesting rwh potential reduce water demand also contributes sustainable objectives including reducing stormwater pollutant loads reducing erosion inducing natural flow regimes means flood control urban streams research involved design construction field testing rwh system used irrigate greenhouses macdonald campus mcgill university quebec canada purpose rwh system collect rainwater roof area approximate horticulture services building macdonald campus mcgill university meet irrigation demands two horticulture research center greenhouses campus approximate may october two years operation found amount rainwater collected meet peak irrigation demands greenhouses amounted almost gal water per day also enough water irrigation nearby student run gardens harvested rainwater clear cause harm plants major problem experienced operation rwh system algae growth one water collection tanks issue resolved covering tank metallic green wallpaper thereby blocking sunlight entering tank rwh system currently used irrigation demonstration project promote learning sustainable technologies campus surrounding communities
smart community distributed system consisting set smart homes utilize smart home scheduling techniques enable customers automatically schedule energy loads targeting various purposes electricity bill reduction smart home scheduling usually implemented decentralized fashion inside smart community customers compete community level renewable energy due relatively low prices typically exists aggregator community wide electricity policy maker aiming minimize total electricity bill among customers paper develops new renewable energy aware pricing scheme achieve target establish proof certain assumptions optimal solution decentralized smart home scheduling equivalent centralized technique reaching theoretical lower bound community wide total electricity bill addition advanced cross entropy optimization technique proposed compute pricing scheme renewable energy integrated smart home scheduling simulation results demonstrate pricing scheme facilitates reduction community wide electricity bill individual electricity bills compared uniform pricing particular community wide electricity bill reduced percent theoretic lower bound
vibratory angioedema rare inherited type physical urticaria characterized acute onset mucosal cutaneous edema triggered vibration report case year old woman elicited use mechanized vibratory dental equipment knowledge first report induced mechanical dental equipment
assess clinical value antistreptolysin aso level adult patients acute tonsillitis group beta hemolytic streptococcus gabhs etiology interaction centor score throat cultures data aso antibody titers throat cultures obtained adult patients acute tonsillitis gabhs etiology initially proven centor score results compared group adult patients recurrent tonsillitis underwent tonsillectomy group healthy adults throat cultures revealed gabhs positive results acute cases recurrent cases significant differences groups significant difference cases gabhs positive gabhs negative throat culture aso titers results mean respectively titers significantly higher established normative data group recurrent tonsillitis cases mean aso titer significantly higher comparison acute cases aso antibody titers significantly higher normative ranges cases acute tonsillitis adults detection elevated titers may lead early antibiotherapy tonsillitis centor score supported aso data less supported throat cultures data research reveal titers might predictive value possible recurrence serve indicator tonsillectomy cases recurrent tonsillitis
treatment cow urine first time explored clayware microbial fuel cell mfc varying dilution different chemical oxygen demand cod feed improvement power output mfc attained increase feed concentration cod however increase influent cod cod decreased power maximum power attained mfc fed diluted urine cow cod concentration cod seven fold higher mfc fed raw urine nitrate removal carbohydrate removal achieved mfc fed cod electrochemical analysis showed electrogenic activity anodic biofilm boosted optimum feed concentration cod cow urine anodic chamber using two mfcs fed diluted cow urine maximum voltage series connection maximum current parallel connection achieved thus cow urine serve sustainable yellow gold harvest bioelectricity using low cost clayware mfc curb water pollution likely caused cattle sheds elsevier ltd rights reserved
series redox dual stimuli responsive poly methacryloyloxyethyl phosphorylcholine block poly histidine mpc copolymers consisting responsive block biocompatible phospholipid analog mpc block connected redox responsive disulfide linker synthesized block copolymers self assembled uniform micelles approximate doxorubicin dox efficiently encapsulated vitro release profile shows enhanced release dox low glutathione gsh vitro cell viability assays performed using various cell lines show blank hybrid micelles acute intrinsic toxicity dependent cytotoxicity observed dox loaded micelles especially moreover confocal microscopy images flow cytometry results show dependent cellular uptake dox loaded micelles therefore dox loaded micelles considered good candidate cancer therapy wiley periodicals inc polym sci part polym chem
purpose prevalence hiv aids infection south african construction industry exceeds economic sectors voluntary counselling testing pivotal combatting spread disease little known attitudinal fear testing among construction workers determinants thereof purpose paper address shortcomings design methodology approach conceptual integrated model fear testing proposed demographic characteristics behavioural cognitive factors posited explain attitudinal fear testing regression analysis structural equation modelling used test model using data gathered site based participants questionnaire survey findings prejudice lifestyle risk terminal predictors fear testing prejudice determined education level hiv aids transmission knowledge knowledge predicted education level ethnicity lifestyle risk determined age gender harmful substance use knowledge harmful substance use determined age gender ethnicity employment type inter relationship knowledge hiv aids prejudice towards hiv persons fear testing complex nuanced practical implications intervention strategies firms positively address attitudinal fear testing employers ensure effective communication established workers interventions relating harmful substance use employees need particular attention awareness campaigns sensitive ethnic cultural values inter generational differences originality value harmful substance use knowledge hiv aids transmission indirect predictors fear testing education ethnicity critical dimensions knowledge complex inter relationship knowledge prejudice lifestyle risk fear testing highlighted providing guidelines intervention management
subsurface defects polished fused silica optics responsible igniting laser damage high power laser system non destructive measurement technique developed detect subsurface photoluminescence defects fused silica fused silica samples polished different vendors applied characterization subsurface defects measurement damage performance subsurface photoluminescence defects fused silica evaluated confocal fluorescence microscopy system laser induced damage threshold damage density measured nanosecond pulse laser results show great differential subsurface quality fused silica samples laser induced damage performance good correlation subsurface defects paper shows new non destructive measurement technique detect photoluminescence defects subsurface layer polished fused silica valuable increasing laser damage performance improving production manufacturing engineering optics
many efforts today aim energy saving promoting user awareness virtuous behavior sustainability perspective houses appliances energy meters devices becoming smarter connected domotics increasing possibilities house automation control ambient intelligence assisted living bringing attention onto people needs different viewpoints assumption considering aspects together allows novel intriguing possibilities end paper combine home energy management domotics coordination technologies intelligent agents ambient intelligence ubiquitous technologies gamification devise novel scenarios energy monitoring management basic brick much wider comprehensive home management system aim control home appliances well beyond energy consumption combining home comfort appliance scheduling safety constraints etc dynamically changeable users preferences goals priorities time usability attractiveness seen key success factors intriguing technologies available houses smart devices exploited make system configuration use simpler entertaining attractive users aspects also integrated ubiquitous pervasive technologies geo localization social networks communities provide enhanced functionalities support smarter application scenarios hereby strengthening technology acceptation diffusion accordingly first analyse system requirements define reference multi layer architectural model butlers architecture specifies seven layers functionalities correlating requirements corresponding technologies consequent value added users layer outline set notable scenarios increasing functionalities complexity discuss structure corresponding system patterns terms proposed architecture make concrete presenting comprehensive interaction examples comic strip stories next discuss implementation requirements met available technologies discuss possible architecture refine concrete case tucson coordination technology present subsystem prototype discuss properties butlers perspective
background chronic otitis media com one common childhood diseases pathophysiology complex multifactorial role specific mucin glycoprotein subtypes recently elucidated objective determine relationship middle ear fluid mucins clinical variables patients needing tympanostomy tubes methods middle ear effusions mee children receiving collected year period western blot characterization mucins mucb mucac along chart review age gender effusion viscosity hearing loss history allergies respiratory disease performed results mee samples patients available analysis overall mucb significantly often detected middle ear fluid relative mucac mucb presence statistically associated mucoid effusions relative serous effusions mucac presence significantly different mucoid serous fluid patients younger months likely present mucoid effusion compared older months age finally patients effusions positive mucb younger effusions negative mucb months variables correlated either effusion viscosity specific mucin content conclusion patients younger age needing placement likely present mucoid effusions predominantly containing mucb mucin postulate distinct pathophysiology mucoid serous effusions across ages children com elsevier ireland ltd rights reserved
study effect oxygen enriched air enrichment performance characteristics brake power brake torque brake mean effective pressure brake specific fuel consumption brake thermal efficiency gasoline internal combustion engine investigated using power software simulation lunched different engine speeds rpm post post processing plots performance parameters versus engine speed results study showed brake power brake torque brake mean effective pressure increase oxygen enriched air condition also according results deference oxygen enriched air normal conditions bsfc bte values although results showed bsfc bte increase slightly oxygen enriched air condition normal condition higher engine speeds
purpose reviewtechnological innovations including text messaging smart phone applications electronic monitoring devices aimed improving asthma controller adherence rapidly introduced clinical care directly marketed patients review analyzes recent clinical trials implementing interventions focus benefits shortcomings recent findingspoor medication adherence continues exert significant morbidity patients asthma objective real time measures monitor adherence overcome limitations prior methods including self report prescription refills technological advances especially incorporating reminder systems demonstrated improved controller adherence increased adherence trials translated consistent clinical improvement including reducing hospitalizations emergency department visits asthma exacerbations possibly secondary study design poor inhalation technique summarynovel monitoring reminder technology augment patient medication adherence provide clues management escalating therapy studies needed investigate overarching clinical impact technology especially grows routine clinical practice
solar energy costs continue drop number large scale deployment projects increases need different analysis models photovoltaic modules academia industry rises paper proposes modified equivalent circuit model modules module comprises several series connected cells generate electrical power cell internal shunt resistance proposed model simplifies standard one diode equivalent circuit sec model removing shunt resistance including effect diode part circuit retaining original model accuracy proposed equivalent circuit called modified sec msec less number circuit elements cells assumed operating ambient conditions share electric voltage current values ensure simplification come reduction accuracy sec model validate msec model simulating conditions calculate compare current voltage characteristics results validate accuracy model difference two models falling therefore proposed model adopted alternative representation equivalent circuit cells modules
soluble elastin like peptides elps engineered range physical forms hydrogels scaffolds fibers artificial tissues finding numerous applications medicine engineering smart polymers elastin like peptides attractive candidates platform novel biomaterial design exhibit highly tunable response spectrum reversible phase transition capabilities report design first virtual library elastin like protein models using methods enhanced sampling study effect peptide chemistry chain length salt concentration structural transitions elps exposing associated molecular mechanisms describe behavior local molecular structure increasing temperatures effect peptide interactions nearest hydration shell water molecules peptide mobility propensity exhibit structural transitions shifts magnitude structural transitions single molecule scale explained perspective peptide ion water interactions library four unique elastin like peptide systems predictions structural transitions subsequently validated experiment library valuable resource recombinant protein design synthesis elucidates mechanisms single molecule level paving feedback path simulation experiment smart material designs applications biomedicine diagnostic devices published elsevier ltd
microbial source tracking mst chemical source tracking cst markers utilized identify fecal contamination harvested rainwater gutter debris samples throughout sampling period bacteroides detected tank water samples gutter debris samples adenovirus detected tank water gutter debris samples respectively human adenovirus detected levels ranging detection limit genome copies tank water debris samples respectively results cst markers showed salicylic acid average prevalent marker gutter debris samples caffeine average prevalent tank water samples acetaminophen detected sporadically throughout study period bacteroides salicylic acid bacteroides caffeine yielded high concurrence frequencies gutter debris samples addition highest concurrence frequency tank water samples observed bacteroides caffeine current study thus indicates bacteroides salicylic acid caffeine may potentially applied source tracking markers rainwater catchment systems order supplement fecal indicator analyses
remote sensing platforms consistently demonstrated ability detect cases identify specific targets interest photovoltaic solar panels shown unique spectral signature consistent across multiple manufacturers construction methods solar panels proven detectable hyperspectral imagery using common statistical target detection methods adaptive cosine estimator false alarms mitigated use spectral verification process eliminates pixels key spectral features photovoltaic solar panel reflectance spectrum normalized solar panel index described key component false alarm mitigation process spectral verification solar panel arrays confirmed openly available literal imagery measured using numerous open source algorithms tools measurements allow assessment overall solar power generation capacity using equation accounts solar insolation area solar panels efficiency solar panels conversion solar energy power using known location readily available information methods outlined paper estimate power generation capabilities within rated power society photo optical instrumentation engineers spie
detecting moving objects scene fundamental critical step many high level computer vision tasks however background subtraction modeling still open challenge problem particularly practical scenarios drastic illumination changes dynamic backgrounds paper present novel background modeling method focused dealing complex environments based circular shift operator background model constructed performing circular shifts neighborhood pixel forms basic region unit foreground mask obtained via two stages first stage subtract established background current frame obtain distance map second adopt graph cut distance map order adapt background changes background model updated adaptive update rate experimental results indoor outdoor videos demonstrate efficiency proposed method
paper introduces benefits linking finite elements analysis laboratory testing experiences structural analysis one particular case studied static analysis railroad bridge metallic structure procedure calibrating analysis model introduced using mesh sensibility analysis strain gage measurements achieving considerable improvements application approaches
background thyroid disease pregnancy common clinical problem since guidelines management disorders american thyroid association ata first published significant clinical scientific advances occurred field aim guidelines inform clinicians patients researchers health policy makers published evidence relating diagnosis management thyroid disease women pregnancy preconception postpartum period methods specific clinical questions addressed guidelines based prior versions guidelines stakeholder input input task force members task force panel members educated knowledge synthesis methods including electronic database searching review selection relevant citations critical appraisal selected studies published english language articles eligible inclusion american college physicians guideline grading system used critical appraisal evidence grading strength recommendations guideline task force complete editorial independence ata competing interests guideline task force members regularly updated managed communicated ata task force members results revised guidelines management thyroid disease pregnancy include recommendations regarding interpretation thyroid function tests pregnancy iodine nutrition thyroid autoantibodies pregnancy complications thyroid considerations infertile women hypothyroidism pregnancy thyrotoxicosis pregnancy thyroid nodules cancer pregnant women fetal neonatal considerations thyroid disease lactation screening thyroid dysfunction pregnancy directions future research conclusions developed evidence based recommendations inform clinical decision making management thyroid disease pregnant postpartum women care must individualized recommendations provide opinion optimal care paradigms patients disorders
advance current knowledge ethical decision making organizations integrate two perspectives thus far developed independently organizational identification perspective ethical climate perspective illustrate interaction perspectives two studies study sample study sample presented participants moral business dilemmas specifically found organizational identification increased moral decision making organization climate perceived ethical addition disentangle effect study participants moral identity argue interactive influence organizational identification ethical climate rather independent influence either perspectives crucial understanding moral decision making organizations
prospectively investigate buscopan affects diagnosis bowel inflammation diffusion weighted imaging enterography dwi mre crohn disease thirty patients without previous bowel surgery underwent dwi mre sec intravenous buscopan patients randomly divided two groups using crossover design interpretations made regarding presence restricted mural diffusion bowel inflammation nine bowel segments two separate reading sessions two readers readers also judged restricted mural diffusion extent bowel segment two side side dwi mre images random right left order ileocolonoscopy conventional mre interpreted expert panel reference standards analyzed bowel segments dwi mre without buscopan significantly decreased sensitivity readers significantly increase specificity two readers noted bowel segments greater diffusion restriction extent dwi mre buscopan compared dwi mre without buscopan respectively similar extent omitting buscopan caused greater loss sensitivity dwi mre false positive reduction diagnosing bowel inflammation aeuro cent omitting buscopan significantly decreases dwi mre sensitivity diagnosing bowel inflammation aeuro cent increase corresponding dwi mre specificity omitting buscopan less apparent aeuro cent dwi mre without buscopan underestimates extent bowel inflammation
purpose china high prevalence smoking characteristics social smoking chinese college students investigated examined pattern social smoking explored association social smoking personal cessation efforts mental health factors among chinese male college students design study design cross sectional survey setting china setting study subjects participants random sample male college students measures participants completed self administered questionnaire examined smoking behaviors group specific mental health factors loneliness self harm suicide depression anxiety analysis analysis conducted using descriptive statistics analysis multivariate logistic regression results total current smokers identified social smokers compared nonsmokers social smokers increased risks depression odds ratio confidence interval among daily smokers social smokers less likely intention quit smoking nonsocial smokers odds ratio confidence interval conclusion study reveals unique psychologic characteristics related social smoking college students particular group interest unhealthy behaviors initiated adolescence may continue adulthood findings provide evidence future tobacco control intervention among population
paper proposes novel unsupervised feature learning algorithm land use scene recognition high resolution remote sensing imagery proposed technique utilizes multipath sparse coding architecture order capture multiple aspects discriminative structures within complex remote sensing sceneries unlike previous sparse coding bag visual words based techniques rely handcrafted feature descriptors scale invariant feature transform proposed technique extracts dense low level features raw data including visual rgb data near infrared nir data using image patches varying sizes different layers proposed technique evaluated three data sets including category merced land use rgb data set spatial resolution category ground scene rgb nir data set category singapore land use rgb nir data set spatial resolution experimental results show proposed technique outperforms state art methods
early differential diagnosis parkinsonian syndromes still remains challenge mainly due similarity symptoms onset disease recently desmethoxyfallypride dmfp suggested increase diagnostic precision effective radioligand allows analyze post synaptic dopamine receptors nevertheless analysis data still poorly covered use limited order address challenge paper shows novel model automatically distinguish idiopathic parkinsonism non idiopathic variants using dmfp data proposed method based multiple kernel support vector machine uses linear version classifier identify regions interest olfactory bulb thalamus supplementary motor area evaluated proposed model binary separation idiopathic non idiopathic parkinsonism multigroup separation parkinsonian variants systems achieved accuracy rates higher outperforming datscan neuroimages purpose addition system combined datscan dmfp data assessed
investigation paper higher order nonlinear schrodinger equation optical fiber lax pair infinitely many conservation laws derived via symbolic computation virtue darboux transformation one two three soliton solutions derived propagation interaction solitons illustrated graphically velocity soliton linearly related higher order dispersion coefficients amplitude soliton depend width one soliton increases decrease intensity complex eigenvalue parameter head interaction two bidirectional solitons well overtaking oscillating interaction two unidirectional solitons presented interactions among three solitons display two head one overtaking interactions along three overtaking interactions graphical analysis shows interaction two solitons elastic interaction among three solitons pairwise elastic published elsevier gmbh
paper focuses application sensitivity analysis typical passively designed high rise residential buildings hot humid climates considering multiple indoor environmental indices impact factors sampling based monte carlo analysis mca adopted carry multiple regression analyses selected input paranieters output indices input parameters including building layout envelope thermophysics building geometry infiltration air tightness extensively cover aspect passive design strategies improve sustainability buildings miscellaneous output indices represent major indoor environment factors lighting ventilation thermal comfort conditions addressed local green building guidance dynamic simulation program generates required outputs based input parameters constructing generic building model different assumptions internal loads ventilation control methods running periods weather conditions calculated sensitivity indices different output indices chances simulation control variables whereas window solar heat gain coefficient window ground ratio consistently among influential design factors addition ashrae adaptive comfort standard acceptability determined adequate assessment method building thermal comfort hot humid climates similar hong kong proposed approach accounts identified impact factors passively designed building therefore help conceive potential sustainable solutions early architectural design stages
background chronic low grade inflammation established risk factor cardiovascular disease inflammatory impact diet reflected concentrations inflammatory markers bloodstream inflammatory potential diet estimated dietary inflammatory index dii associated cardiovascular disease risk previous studies aimed examine association dii risk first myocardial infarction population based study long follow method conducted prospective case control study verified cases first matched controls nested within population based cohorts northern sweden health disease study nshds largest ongoing vasterbotten intervention programme vip nearly participants study period median follow recruitment diagnosis years men women dii scores derived validated food frequency questionnaire ffq administered multivariable conditional logistic regression models used estimate odds ratios confidence intervals using quartile anti inflammatory diet reference category validation general linear models used estimate association dii scores two inflammatory markers high sensitivity reactive protein hscrp interleukin subset study population results male participants pro inflammatory dii scores increased risk orqvsq trend essentially unchanged adjustment potential confounders including cardiovascular risk factors orqvsq trend association found dii women increase one dii score unit associated higher hscrp higher controls biomarker data available conclusion pro inflammatory diet associated elevated risk first myocardial infarction men whereas women relationship null consideration inflammatory impact diet could improve prevention cardiovascular disease
adolescents need information sex related topics order reduce risk behavior engage healthy sexual decision making parents potential important source information using national survey family growth examined associations parent adolescent communication age sex related topics hiv testing among respondents aged ever sexual intercourse women men analyses showed men women discussing prevent hiv aids use condom parent age positively associated hiv testing among women discussions methods birth control get birth control stds positively associated hiv testing developing strategies interventions facilitate parent adolescent communication sex related topics particularly hiv prevention condom use may important increase hiv testing among young women men
requirements concerning technical availability part overall equipment effectiveness increase constantly production nowadays unplanned downtimes prevented via efficient methods predictive condition based maintenance represents valuable approach fulfilling demands precise models state estimation missing manufacturers point view challenge consists wear models capability specifying correct component state well providing reliable failure forecasts unfortunately nowadays creation wear models based specific stress tests design experiments manufacturer integration production phase even data feedback user knowledge take place new potential promised cross cutting technologies ict like cloud technologies general virtual platform concepts approaches machine learning enabling technologies objective paper adopt existing algorithms new application condition monitoring order evaluate applicability automated training robust wear models context commonly used algorithms described reader gets impression challenges met dealing machine learning selection ten algorithms variants evaluated four different features within packaging machine outlook embedding trained model cloud architecture presented
model roadway suspension bridge thin rectangular plate study detail oscillating modes plate assumed hinged short edges free long edges two different kinds oscillating modes found longitudinal modes torsional modes analyze fourth order hyperbolic like equation describing dynamics bridge order emphasize structural behavior consider isolated equation forcing damping due nonlinear behavior cables hangers structural instability appears finite dimensional approximation prove system remains stable low energies numerical results show larger energies system becomes unstable analyze energy thresholds instability show model allows give answers several questions left open tacoma collapse elsevier ltd rights reserved
paper new cmos operational amplifier using darlington pair based gain boosted technique enunciated proposed opamp shows high gain well high ugb using capacitor compensation technique proper biasing circuit operated rail rail power supply amplifier highly useful wireless communications due low power consumption high bandwidth high gain high noise immunity designed operational amplifier gain bandwidth ghz phase margin slew rate circuit designed using cadence analog digital system design tools gpdknm technology
paper proposes new power management strategy based theory fuel cell electric vehicle applications using modular cascaded converter topology one power source could combined capacitors supply active reactive power efficient manner electric motor control strategy separate mean oscillating active power reactive power well capacitors voltage regulation control described simulation results shown validate control strategy experimental results using minimal topology prototype static load show practical application control
photos lead people believe true false events happened even photos provide evidence events occurred research shown nonprobative photos increase false beliefs combined misleading suggestions repeated exposure photo target event propose photos exert similar effects without factors test proposition five experiments experiment people saw names several animals pretended give food take food people saw animal names half photo animal half alone decided whether experience photos led people believe experiences animals moreover experiments provided evidence photos exerted effects making easier bring related thoughts images mind feeling people mistook evidence genuine experience experiment photos led people believe positive claims past negative claims consistent evidence feelings ease selectively increase positive judgments experiment also showed photos like manipulations ease bias people judgments broadly producing false beliefs people pasts finally experiment photos exerted powerful effects depicted unfamiliar animals thus could help bring information mind findings suggest nonprobative photos distort past without factors encourage false beliefs operate helping related thoughts images come mind
paper presents results research project aimed developing evaluating viability fuel cell vehicles urban public transit applications investigating ways commercialize considering low floor bus design high efficiency powertrain one salient characteristics proposed fuel cell battery hybrid bus drive axle integrates two near wheel permanent magnet synchronous motors pmsms rear axle important part vehicles powertrain drive axle employed drive vehicle capture breaking energy match required speeds differential configuration parameters powertrain hybrid fuel cell battery bus given detail extend life fuel cell stacks change output power fuel cell stacks controlled gradual via converter depending energy management strategy described paper energy analysis based chosen driving cycle conducted study efficiency proposed powertrain shows hydrogen consumption bus also road test results indicated tractive capabilities maneuverability bus reach design specifications copyright hydrogen energy publications llc published elsevier ltd rights reserved
paper introduces comparative study design aerospace actuators concerning induction motor permanent magnet motor technologies analysis undertaken two candidate configurations evaluated terms electromagnetic thermal behaviors combined manner first step basic dimensioning actuators fundamental operational characteristics determined via time stepping finite element analysis consideration thermal robustness proposed motor configurations integrated design procedure appropriate handling respective constraints result comparisons carried common thermal evacuation basis second step single objective optimization procedure employed considering several performance efficiency indexes using appropriate weights manufacturing construction related costs investigated topologies considered employing specific penalty functions impact utilized materials also examined resultant motor designs validated manufactured prototypes illustrating suitability aerospace actuation
previous studies precise computation methods iron loss shown dynamic magnetic field analysis hysteresis post processing effective however problem hysteresis makes convergence nonlinear iterations unstable paper proposes stabilization method dynamic magnetic field analysis hysteresis proposed method characterized approach improving initial value step size newton raphson method results paper showed convergence characteristic nonlinear magnetic field analysis variety flux density waveforms part electric motor improved using proposed method
paper presents development remote experimentation automatic control engineering education using smartphone application students interact real laboratory didactic equipment friendly graphical user interface information provided built smartphone sensors students modify process parameters verify real time happening experimental setup mobile device vibration technology used add haptic tactile feedback application additional sense complements visual hearing information user usually acquires performing practical experience therefore students pay attention results achieved online taking advantage today smartphone technological features students feel highly motivated use device achieve improvements learning process reach great number users application runs across widely used mobile platforms user lab activities stored database teacher later analysis likewise students store resulted experiments mobile device finished order make line result analysis
recent experiments asdex upgrade tokamak aim improving physics base iter demo aid machine design prepare efficient operation type edge localized mode elm mitigation using resonant magnetic perturbations rmps shown low pedestal collisionality ped contrast previous high regime suppression occurs narrow rmp spectral window indicating resonant process concomitant confinement drop observed due reduction pedestal top density electron temperature strong evidence found ion heat flux decisive element power threshold physics based scaling density minimum occurs indicates iter could take advantage initiate mode lower density final operational point core density fluctuation measurements resolved radius wave number show increase introduced axis electron cyclotron resonance heating ecrh mainly increases large scale fluctuations radial variation fluctuation level agreement simulations using gene code fast particles shown undergo classical slowing absence large scale magnetohydrodynamic mhd events low heating power show signs anomalous radial redistribution large heating power consistent broadened axis neutral beam current drive current profile conditions neoclassical tearing mode ntm suppression experiments using electron cyclotron current drive eccd feedback controlled deposition allowed test several control strategies iter including automated control ntms single discharge disruption mitigation studies using massive gas injection mgi show increased fuelling efficiency high field side injection saturation fuelling efficiency observed high injected mass needed runaway electron suppression large locked modes significantly decrease fuelling efficiency increase asymmetry radiated power mgi mitigation concerning power exhaust partially detached iter divertor scenario demonstrated sep asdex upgrade peak time averaged target load around well consistent component limits iter developing towards demo full detachment achieved sep stationary discharges core radiation fraction order demo requirements instead needed iter demonstrated finally remains difficult establish standard iter scenario low tungsten asdex upgrade due observed poor confinement low beta mainly due degraded pedestal performance hence investigations shifting operational point higher beta lowering current started higher pedestal performance recovered seeding well interpreted improved pedestal stability due decrease bootstrap current increasing eff concerning advanced scenarios upgrade ecrh power allowed experiments central ctr eccd modify profile improved mode scenarios showing increase confinement still good mhd stability flat elevated profiles values
background urban bicycle couriers may high incidence injuries messengers work contractors hence injuries well documented methods quantify injury rates severity among urban bicycle couriers convenience sample couriers city boston completed two page self administered survey results working couriers suffered least one injury resulting either days lost work visits health care professional hospital annual incidence rate injuries resulting days away work bike couriers bone fractures accounted days lost work followed dislocations sprains strains collisions avoiding collisions motor vehicles including doored collisions pedestrians accounted majority events leading injury twenty four percent messengers reported wearing helmet regular basis health insurance conclusions urban bicycle messengers poorly documented largely unstudied workforce suffer high rate occupational injury wiley liss inc
understanding suggestive practices promote false beliefs false memories childhood events important many settings psychotherapeutic medical legal generalisability findings memory implantation studies questioned due variability estimates across studies variability partly due false memories operationalised differently across studies differences memory induction techniques explored ways defining false memory based memory science developed reliable coding system applied reports eight published implantation studies independent raters coded transcripts using seven criteria accepting suggestion elaboration beyond suggestion imagery coherence emotion memory statements rejecting suggestion using scheme cases classified false memories another classified accepted event degree suggestion included self relevant information imagination procedure accompanied photo depicting event memory formation rate research demonstrates useful procedure systematically combining data amenable meta analysis provides valid estimate false memory formation associated moderating factors within implantation literature date
many existing electricity markets mixed type pool auction bilateral contracts producers distributors case problem faced generation company genco maximizing revenues participating market pool auction honoring bilateral contracts agreed revenue fixed extension mixed markets medium term model successfully employed auction markets presented results non convex expected revenue function maximized subject constraints currently available direct global optimization solvers prove efficient enough heuristic procedure based sequence solutions nonlinear solver presented numerical results obtained several realistic cases show satisfactory results test cases presented dispatchable non dispatchable renewables consider medium term pumping together conventional units gencos participating mixed market advantages gencos employing medium term results produced model presented include among others evaluation expected profitability bilateral contracts elsevier rights reserved
magnetorheological shear thickening fluid smart material exhibits magnetorheological shear thickening effects study focuses design development novel magnetorheological shear thickening fluid based linear damper first micron sized carbonyl iron particles weight fraction immersed among shear thickening fluid base thoroughly mixed high shear condition produce magnetorheological shear thickening fluid monotube damper bypass designed fabricated testing results using mts machine show influence incorporating shear thickening fluid allows magnetorheological shear thickening fluid filled damper work different dynamic loading velocities stiffness damping changed simultaneously dynamics damper depend variations magnetic field measured responses magnetorheological shear thickening fluid filled damper prove dampers effect shear thickening effect contrast magnetorheological shear thickening fluid filled damper behaves like conventional magnetorheological fluid filled damper shear thickening effect restrained effect becomes obvious higher iron volume
recent studies shown huge steady increase elderly population eventually becomes predominant aspect society effective solutions costly aspect needed recently lot work conducted ambient assisted living aal focuses elderly peoples need ambient intelligence technologies widely researched developed aiming build safe environment help maintain independent lifestyle elderly people however aal still growing area fundamental issues remain open yet solved believe features essential towards effective aal service help elderly paper proposes novel way combining different techniques detect dining utensil spoon eating dining table help kinect tools detect spoon combining different shapes produces high accuracy
presented scientific results obtained motion modeling complicated technical systems aerospace equipment consideration nonlinearities computerized panel allows measure mutual influence system motion stabilization device consideration real characteristics developed analysis motion stability system general carried time relationships system motion taking account nonlinearities presented
autism known spectrum disorder asd seen early childhood three years age asd neuro developmental disorder characterized deficits social responsiveness impairments verbal nonverbal communication purpose paper demonstrate relevance learning technology area training caregivers autistic children search focused number data banks contain numerous references autism home based treatment results found ten papers published since met criteria inclusion six demonstrations learning teach caregivers professionals basics applied behavior analysis techniques skill training remainder studies fell telehealth category involved direct communication professional caregiver home studies suggest home based service delivery effective offers social service system parents considerable financial savings use web based platform learning telehealth depicted aid caregivers autistic children need studies variables related home based service delivery noted
introduction study examined potential feasibility tele delivered parent coaching rural area italy survey parents attitudes towards type intervention methods parents children six years age registered diagnosis autism spectrum disorder clinic catering area invited take part study final sample consisted parents results parents worse internet skills reported lower levels satisfaction currently received services less likely willing enrol trend parents lower self efficacy less likely enrol educational level previous experience video calling travel time clinic child level ability associated choice enrolment discussion implications strategies contrast barriers adoption strengthen implementation plans discussed
way nature evolves sculpts materials using proteins inspires new approaches materials engineering still completely understood present cell free synthetic biological platform advance studies biologically synthesized solid state materials platform capable simultaneously exerting many hierarchical levels control found natural biomineralization including genetic chemical spatial structural morphological control supporting evolutionary selection new mineralizing proteins corresponding genetically encoded materials produce dna directed protein expression enzymatic mineralization occur polystyrene microbeads water oil emulsions yielding synthetic surrogates biomineralizing cells screened flow sorting light scattering signals used sort resulting mineralized composites differentially demonstrate utility platform evolutionarily selecting newly identified silicateins biomineralizing enzymes previously identified silica skeleton marine sponge enzyme variants capable synthesizing silicon dioxide silica titanium dioxide titania composites mineral composites intermediate strength preferentially selected remain intact identification cell sorting collapse postsorting expose encoding genes enzymatic dna amplification newly selected silicatein variants catalyze formation crystalline silicates whereas parent silicateins lack ability demonstrated bioengineered route previously undescribed materials introduces vitro enzyme selection viable strategy mimicking genetic evolution materials occurs nature
organizational change become complex challenging employee attitudes beliefs toward change even important article proposes theoretical framework authentic leadership may influence followers change oriented attitudes beliefs behaviors follower psychological resources including hope trust optimism self efficacy resilience influence readiness change change implementation maintain authentic leader behavior influence followers change oriented behaviors participation decision making processes change initiatives organization citizenship behavior organizational learning processes forming coalition change developed propositions empirical investigation
three experiments reported examined capacity match voice static image face using simultaneous different matching task performance significantly better chance experiments however appear depend either sex speaker sex listener stimulus distinctiveness self reported strategies experiment concerns floor effects well significant response bias prompted change task performance examined matching voice face lineup interesting pattern emerged performance significantly better chance addition demonstrably affected distinctiveness speaker voice results considered context theoretical discussions regarding face voice integration context applied considerations regarding multimodal benefits witness scenarios
objectives findings several experimental studies animals suggested protective action testosterone kidney function hard evidence association humans scarce examined association testosterone levels kidney function among adult men living super aged communities design setting participants measurements conducted cross sectional study involving residents aged years participated annual health check ups communities total men recruited main exposure salivary testosterone levels measured using enzyme linked immunosorbent assay main outcome estimated glomerular filtration rate egfr determined age gender serum creatinine levels results participants analyzed median age egfr years min respectively comparison percentile levels lower levels general linear model restricted cubic splines showed lower levels associated decreased egfr adjustment sociodemographic characteristics comorbidities blood pressure example fifth percentile associated decreased egfr difference egfr min confidence interval comparable magnitude reduction egfr observed year increase age population association low testosterone levels decreased egfr remained similar even analyses restricted participants aged years participants median age years conclusions results study indicated low testosterone levels independently associated reduced egfr adult men finding association low testosterone levels reduced kidney function needs corroborated among persons chronic kidney disease longitudinal study amda society post acute long term care medicine
data conversion raster spiral coordinates key function scanning process roll powder sintering rps additive manufacturing technology conversion process especially important produces basis processed object many equations conformal transformation still room improve computation efficiency paper presents efficient conversion algorithm processes objects linear transforming rolling ribbon new algorithm several significant advantages old ones due applying one main linear equation program based linear algorithm simpler compact faster comparison programs use trigonometric transcendental equations proposed algorithm developed extensively tested several parts computer aided design models rps processing
battery electric vehicles bevs often portrayed green implying negligible greenhouse gas ghg emissions bevs zero emission vehicles electrical power generators used recharge vehicle batteries emit copious ghgs analysts estimated power plant ghg emissions due charging batteries using average electrical generator grid mix given region however ghg protocol specifies analysts use marginal grid mixes accurately calculate ghg emissions adding evs vehicle fleet paper utilizes marginal grid mixes electrical power region calculates vehicle weighted average ghg emissions entire country calculations demonstrate average bev displaces gasoline hybrid electric vehicle hev increase ghgs phev put service increase ghgs average compared gasoline hev copyright hydrogen energy publications llc published elsevier ltd rights reserved
sine signals widely used signal processing communication technology system performance analysis system identification many periodic signals transformed sum different harmonic sine signals using fourier expansion paper studies parameter estimation problem sine combination signals periodic signals order perform online parameter estimation stochastic gradient algorithm derived according gradient optimization principle basis multi innovation stochastic gradient parameter estimation method presented expanding scalar innovation innovation vector aim improving estimation accuracy moreover order enhance stabilization parameter estimation method recursive least squares algorithm derived means trigonometric function expansion finally simulation examples provided show compare performance proposed approaches
misinformation deese roediger mcdermott drm paradigms used study forms false memories despite abundance research using two paradigms studies examined relationship errors arise present study participants completed misinformation task two drm tasks receiving warning effect second drm task participants demonstrated misinformation drm effects without warning susceptibility forms false memory significantly related across individuals drm warning reduced drm effect signal detection analysis revealed drm warning reduced liberal response bias task sensitivity response bias drm tasks significantly related measures misinformation task findings suggest two forms false memories interchangeable appear result different cognitive processes
based recent findings main span vincent thomas suspension bridge crosses directly palos verdes fault capacity produce devastating earthquake spring bridge underwent major retrofit using visco elastic dampers study focuses seismic vulnerability retrofitted bridge three dimensional memberbased detailed panel based simplified finite element models bridge developed order show appropriateness models eigenproperties bridge evaluated compared system identification results obtained using ambient vibration data addition model validation performed simulating dynamic response northridge earthquake comparing measured response finally considering set strong ground motions los angeles area nonlinear time history analyses performed ductility demands critical sections presented terms fragility curves study shows ground motion peak ground acceleration greater result plastic hinge formation one locations probability exceedance also found effect dampers minimal low moderate earthquakes high strong earthquakes
article proposed new scheme encrypt highly autocorrelated image pixel data existing literature single substitution used break autocorrelation images get better results instead single substitution box researchers minimizing autocorrelation via utilizing multiple substitution boxes however found multiple substitution boxes solve problem autocorrelation independently therefore added chaotic confusion diffusion existing substitution scheme order remove correlation completely initially break autocorrelation data permuting pixels via ercs chaotic map bitwise xor carried diffusion using logistic map followed existing substitution scheme experimental analysis shows proposed scheme greater resistance brute force attack statistical attack analyses statistical analysis peak signal noise ratio contrast analysis key space analysis entropy analysis correlation analysis key sensitivity analysis encryption quality analysis proved high robustness proposed scheme
commonly known saffron crocus sativus active components shown several useful pharmacological effects anticonvulsant antidepressant anti inflammatory antitumor radical scavenger effects learning memory improving effects etc increasing body data saffron use medical databases within last years current review strengths weaknesses clinical trials different pharmacological effects saffron discussed sativus extract studied antidepressant clinical trials comparison placebo antidepressant drugs saffron showed effectiveness antidepressant drug clinical trials anti alzheimer effect saffron demonstrated effective placebo effective donepezil clinical trials antipruritic complexion promoter skin care effects saffron confirmed saffron efficient placebo another clinical trial proved addition weight loss treatment saffron could reduce snacking frequency clinical trials conducted women premenstrual syndrome showed saffron could reduce suffering symptoms placebo similar standard treatments furthermore additional clinical trials effects saffron erection dysfunction allergies cardiovascular immune system well safety toxicity human pharmacokinetics reviewed herein
conformal approach anomaly detection recently developed reliable framework classifying examples normal abnormal groups based training data set containing normal examples validity property normal example generated distribution examples training set classified anomaly probability bounded pre selected significance level parallel processing big data may require split training set several sources also assume collection data two sources might done parallel data distribution may differ sources contribution work conformal anomaly detection studying ways keeping conformal validity training set obtained heterogeneous differently distributed sources
fetal neonatal autoimmune hyperthyroidism rare serious transient disorder early diagnosis treatment key objectives optimal prognosis well child review focuses management patients fetal neonatal periods propose diagnostic algorithm high risk pregnancies mothers current past hyperthyroidism related graves disease involving repeated fetal thyroid gland assessments weeks gestation onwards maternal serum thyroid stimulating hormone receptor antibody trab determination close monitoring trab levels exceed times upper limit normal range fetuses goiter main clinical issue determining whether cause maternal antithyroid drug atd treatment appropriate achieving normal maternal thyroid function inappropriate excessive fetus resulting hypothyroidism necessitating decrease atd dose pregnancy presence trabs resulting fetal thyroid stimulation hyperthyroidism requiring increase maternal atd dose methimazole carbimazole treatment initiated soon possible neonatal period carefully managed maintained period months stopped trab longer detectable serum karger basel
study design retrospective study posterior approach surgical treatment thoracolumbar pseudarthrosis ankylosing spondylitis objective aim current study report surgical results symptomatic thoracolumbar pseudarthrosis posterior approach summary background data spinal pseudarthrosis well known complication condition may complicate mechanical back pain spinal deformity sometimes neurological deficits conservative treatment often fails situation surgical treatment required however optimal surgical procedure condition still controversial methods january december patients spinal pseudarthrosis thoracolumbar segment treated surgically failure months conservative treatment indications surgery persisting back pain patients combined neurological deficits patients spinal deformities patients transforaminal transpedicular debridement pseudarthrosis anterior column performed posterior approach complete debridement bone graft anterior open wedge defect pseudarthrosis performed posterior approach posterior pedicle screws placed fixation clinical radiographic outcomes assessed average follow months range results persistent back pain obtained significant relief cases surgery four patients neurological deficits showed complete recovery neurological function follow spinal deformities cases obtained correction solid bony fusion achieved cases correction loss follow conclusions symptomatic thoracolumbar pseudarthrosis posterior transforaminal transpedicular approach provide circumferential stability anterior bone graft neurological decompression simultaneously supplemental anterior approach may avoided method
mothers fathers emotion socialization practices widely associated child socioemotional outcomes extend research examined bidirectional relationship parent practices supportive non supportive parenting internalizing behavior problems children anglo latino parents participants mothers fathers children without intellectual disability compared stability mother father practices across child ages utilized cross lagged panel modeling examine bidirectional relationship parents child internalizing behavior problems emotion socialization practices differed across time parent gender mothers displaying higher levels supportive parenting lower levels non supportive parenting fathers cross lagged panel models revealed differential relationships child internalizing behaviors emotion socialization practices parent gender ethnicity implications intervening culturally diverse families children discussed elsevier ltd rights reserved
task generating network based evidence support network forensic investigation becoming increasingly prominent undoubtedly evidence significantly imperative used diagnose respond various network related issues performance bottlenecks routing issues etc importantly leveraged infer investigate network security intrusions infections context paper proposes proactive approach aims generating accurate actionable network based evidence related groups compromised network machines campaigns approach envisioned guide investigators promptly pinpoint malicious groups possible immediate mitigation well empowering network digital forensic specialists examine machines using auxiliary collected data extracted digital artifacts one hand promptness approach successfully achieved monitoring correlating perceived probing activities typically first signs infection misdemeanors hand generated evidence accurate based anomaly inference fuses data behavioral analytics conjunction formal graph theoretic concepts evaluate proposed approach two deployment scenarios namely enterprise edge engine global capability security operations center model empirical evaluation employs real botnet traffic real darknet traffic indeed demonstrates accuracy effectiveness simplicity generated network based evidence author published elsevier ltd behalf dfrws
logging become fundamental feature within modern computer operating systems fact logging may used variety applications fashion system tuning auditing intrusion detection systems syslog daemon logging implementation unix linux platforms windows event log logging implementation microsoft windows platforms logging implementations provide application program interfaces turn simplify logging functions data collection data storage paper survey unix linux windows logging mechanisms introduce security issues copyright john wiley sons ltd
previous works presented experimental investigations brittle material removal fraction brf machined surface optical glass related area fraction brittle material removed machined surface used assess surface roughness optical glass precision grinding general subsurface damage ssd considered one important machining qualities grinding optical glass work presents experimental investigation relationship brf ssd depth optical glass precision grinding understand significance brf sensing ssd optical glass series precision grinding experiments conducted precision grinder machine investigate influence grinding parameters ssd depth based image processing algorithm developed previous work brf calculated using microtopography image machined surface glass precision grinding experimental results show brf determined different machining parameters cutting depth wheel speed feed rate dependent ssd depth precision grinding implies brf potential application rapid affordable online vision measurement approach monitor surface subsurface qualities grinding brittle materials
people come falsely remember performing actions actually performed common accounts false action memories invoked source confusion overlap sensory features largely ignored role motor processes addressed lacuna paradigm participants first perform perform actions observe another person performing non performed actions paradigm observation videos showing another actions later induce false self attributions actions observation inflation effect contrary sensory feature account consistent motor simulation account found effect even perceptually impoverished action videos majority sensory features absent motion cues preserved experiment created conditions action observation impede motor simulation predicted found effect observation reduced participants executed movements incongruent congruent observed actions experiment discuss processes produce associations self observed others actions later affect observers action memory elsevier rights reserved
present tomenovela stimulus set developed provide set normatively rated socio emotional stimuli showing varying amount characters emotionally laden interactions experimental investigations cognitive affective theory mind tom iii emotional reactivity complex emotion judgment respect ekman basic emotions happiness anger disgust fear sadness surprise ekman friesen stimuli generated focus ecological validity consist scenes depicting daily life situations two eight main characters distinct biographies personalities depicted scene picture obtain initial evaluation stimulus set pave way future studies clinical populations normative data stimulus set obtained sample neurologically psychiatrically healthy participants female male mean age including visual analog scale rating ekman basic emotions happiness anger disgust fear sadness surprise free text descriptions content scene tomenovela developed provide standardized material social scenes available researchers study social cognition facilitate experimental control keeping ecological validity high
ability solve complex problems essential skill construction project manager must possess entering architecture engineering construction industry ability requires mixture problem solving skills composed lower higher order thinking skills include ability develop evaluate construction plans manage execution plans however introducing students complex problems challenge typical construction educational program support challenge traditional methodology delivering design engineering construction instruction going technological revolution due rise computer based technology example engineering classrooms disciplines educational simulation games used support development problem solving skills paper presents evidence support contention educational simulation games help learning retention transferable problem solving skills crucial solve complex construction problems sample group architectural engineering students year construction class participated quasi experiment play three modules virtual construction simulator vcs acrossover repeated measures quasi experimental design assessed gains problem solving skills construction students gained playing vcs participants completed three learning modules vcs assessed treatment based series analyses results researchers able conclude students gained transferred problem solving skills playing vcs modules study provides evidence implementation educational simulation games support gain problem solving skills necessary solve complex construction problems
background autologous chondrocyte implantation aci durable treatment patients chondral defects study presents comprehensive evaluation patients patella defects treated aci medium long term follow methods thirty consecutive patients isolated chondral lesions patella enrolled prospectively primary outcome measures validated patient reported outcome measures objective magnetic resonance imaging results nineteen patients underwent tibial tubercle osteotomy tto correct lateral maltracking combination soft tissue balancing defect sizes large averaging range pidoriano fulkerson classification revealed defects type lateral type iii medial type central panpatella age time surgery years follow years knee function rated good excellent patients fair patients poor patient three patients failed treatment mean months years failures workers compensation cases older non patients years compared non years significant increases clinical health utility outcome scores seen magnetic resonance imaging demonstrated fill grade surface integrity repair tissue correlated clinical scores conclusion aci isolated patella defects results significant functional improvement minimum months results remaining durable latest follow years level evidence level
objective study present theoretical paper clinical issue aim propose clinical semiological considerations psychopathological conception psychopathy discuss several major theoretical works dedicated nosographic entity mainly schneider psychopathic personalities london cassell cleckley mask sanity louis mosby hare hare psychopathy checklist revised manual toronto multi health systems also examine significant issue raised cooke psychol assess person disord psychiatry suppl int forensic ment health namely whether psychopathic functioning consistently related antisocial behavior theoretical essay informed clinical situations involving psychopaths interviewed prison forensic centers method applied phenomenological psychopathology analysis clinical material first compare binswanger conception mania psychopathic functioning patient behavior similar difference related dialectic ego alter ego patient mania fundamental crisis ego psychopath second finding investigations concerns emotions adaptive dimension psychopathic disorder epistemological discussion concept emotions reveals psychopaths competent management emotional stimuli confers psychological advantage upon karger basel
dissemination implementation evidence based treatments among biggest challenges facing clinical psychiatry developing scalable evidence based treatments major priority fraught challenges article describes development technology based innovations discusses use massive open online courses moocs mobile applications three projects presented modification mooc methodology psychotherapy training clinicians manualized family based therapy fbt adolescents anorexia nervosa modified mooc platform delivery pet development mobile applications treatment augmentation delivery
environmental challenges posed global warming himalayan region include early rapid melting snow glaciers creation new lakes expansion old ones posing high risk glacial lakes outburst flood glof hazard downstream communities according various elevation ranges lakes analyzed basinwide hindu kush karakoram himalaya hkh ranges pakistan using multisensor remote sensing data period overall increase glacial lakes observed various altitudinal ranges noticeable change number within range analysis carried glacial fediakes nonglacial fed lakes different river basins indicated variable patterns depending geographic location hkh region correlation analysis parameters like lake area expansion rate elevation performed glacial lakes distributed various river basins three hkh ranges lake area elevation showed negative relationship basins except hunza shigar shyok correlation expansion rate lakes elevation positive side swat gilgit shigar shingo basins situation may attributed variable altitudinal pattern temperature precipitation order explore diverse patterns lake behavior relationship influential factors hkh detailed studies based using high resolution image data coupled situ information prerequisite although increase lake area observed would favorable water resource management could alarming context glacial flood hazards need monitored critically long term basis elsevier rights reserved
neural network technique known kohonen unsupervised training coupled modified version particle swarm optimization technique effort develop algorithm capable finding multiple optimal solutions given problem results five example problems increasing difficulty validate alternative analysis networking algorithm functionality
background aim evaluate whether cell origin coo defined hans algorithm myc bcl coexpression twomain biological risk factors elderly patients treated rituximab cyclophosphamide doxorubicin hydrochloride vincristine prednisolone chop maintain prognostic value large prospective clinical trial patients methods evaluated paraffin embedded samples patients years age enrolled lymphoma study association trial lnh treated chop correlated coo defined transcriptome according wright algorithm defined hans algorithm subset tumors available frozen tissue samples results non germinal center cell like phenotype according hans algorithm bcl expression myc bcl coexpression predicted worse progression free survival hazard ratio respectively overall survival respectively independently international prognostic index correlation hans algorithm wright algorithm almost perfect concordance according kappa test conclusions results suggest immunohistochemically defined coo remains useful tool predicting prognosis diffuse large cell lymphoma performed optimized standardized conditions bcl expression may help identify elderly patients risk relapse could potentially respond anti bcl targeted agents prospective phase iii trial coexpression myc bcl appear predict worse survival
parents children autism spectrum disorder asd frequently report poor psychological well previous research supported mindfulness based interventions enhance psychological well parents children asd studies topic still rare purpose study examine effectiveness brief mindfulness based intervention mbi perceived stress anxiety depression among parents children asd jordan quasi experimental pretest posttest design comparison group used sample parents children asd completed study parents matched measures age gender level severity asd children based dsm criteria randomized one two groups intervention group participated week mindfulness based intervention program participants comparison group attended program pretest posttest measures participants groups poor psychological well intervention program intervention program one way analyses covariance ancova indicated parents intervention group better outcomes measures psychological well mindfulness comparison group furthermore results paired samples test indicated parents intervention group demonstrated significant improvements measures stress anxiety depression mindfulness scores medium large effect size cohen although comparison group demonstrated small improvement measures dependent variables improvements much less improvements intervention group mbis culturally adaptable feasible effective interventions improve psychological well parents children asd
large increase number hotels brazil added current concern reduce use natural resources preference consumers companies adopt environmental measures management plans rainwater harvesting system become increasingly common various levels infrastructure country following paper bibliographic review current legislation deals regulation use rainwater harvesting system bringing international examples beyond pioneers brazilian legislation specifically aimed subject paper also brings legislation proposal encourages management rainwater part hotel projects way enhance competitiveness reduce costs contribute rational efficient use water resources reducing volume water discharged municipal drainage system
video visualization considered essential part multimedia visual analytics many challenges arisen enormous video content cameras solved help data analytics hence gaining importance however rapid advancement digital technologies resulted explosion video data stimulates needs creating computer graphics visualization videos particularly paradigm smart cities video surveillance widely applied technology generate huge amount videos surveillance paper state art algorithm proposed conversion traffic video content google map time stamped glyph based visualization used effectively outdoor surveillance videos used event aware detection form traffic visualization potentially reduce data complexity holistic view larger collection videos efficacy proposed scheme shown acquiring several unprocessed surveillance videos testing algorithm without pertaining field conditions experimental results show proposed visualization technique produces promising results found effective conveying meaningful information alleviating need searching exhaustively colossal amount video data
need accelerating power grid simulation high performance computing hpc long recognized prior efforts devoted developing one parallel computing applications particular power grid functions non transferable software codes duplicated implementations prior efforts major barrier widespread hpc adoption power grid applications modern hpc hardware architecture require significant computing expertise application development gridpack software framework described paper provides hpc compatible software structure access modern parallel solvers hpc ready modules common components power grid simulation applications gridpack hides hpc details enables power system developers focus applications instead computational details several example applications gridpack presented demonstrate capabilities gridpack performance hpc simulations large power grid networks examples discussed include dynamic simulation application capable running bus western electricity coordinating council wecc system computational speed faster real time simulation static contingency analysis application using task manager dynamic contingency analysis application utilizing two levels parallelism example applications illustrate gridpack capabilities support different types simulations within unified framework support reuse transferable software codes across power grid applications computational results indicate strong performance improvements power grid simulations gridpack elsevier rights reserved
paper study navier stokes equations navier boundary conditions bounded domain prove existence ofweak solution omega omega infinity using fixed point theorem case copyright john wiley sons ltd
people perceptions others self esteem correspond others explicit self esteem test whether implicit self esteem also affects perceptions self esteem zero non zero acquaintance targets completed measures implicit explicit self esteem photographs taken completed self related interviews unacquainted perceivers rated targets self esteem viewing varying degrees information targets study pre selected high low implicit self esteem targets studies perceivers viewed photographs target explicit self esteem predicted self esteem ratings however perceivers read targets interview transcripts target explicit implicit self esteem predicted self esteem ratings targets described sensitive information apparent comfort self certainty associated ratings self esteem cues moreover valid indicators implicit self esteem
background increases hemosiderin laden macrophages hlm reported observed idiopathic pulmonary fibrosis ipf according recent study significant correlation hemosiderin deposition lung tissue ipf pulmonary hypertension evaluated echocardiography suspected study aimed evaluate whether hlm bronchoalveolar lavage fluid balf factor correlated pulmonary hemodynamic parameters evaluated right heart catheterization patients ipf methods initial data consecutive patients ipf underwent surgical lung biopsy november march retrospectively analyzed hlm score balf established dividing number perls prussian blue stain positive macrophages total number macrophages counted results balf showed elevated hlm score right heart catheterization revealed mean pulmonary arterial pressure mpap mmhg pulmonary vascular resistance pvr wood units hlm score positively correlated mpap rho rho pvr rho rho multivariate analysis min walk distance standardized partial regression coefficient beta minimum oxygen saturation min walk distance beta rho hlm score beta rho independently correlated pvr conclusions hlm score balf independent factor correlated pvr patients ipf
background pre mrna splicing involves stepwise assembly pre catalytic spliceosome followed catalytic activation splicing catalysis disassembly formation pre catalytic spliceosomal complex involves incorporation tri snrnp group non snrnp specific proteins saccharomyces cerevisiae prp snu proteins recruited components tri snrnp metazoan orthologs prp snu associate independently tri snrnp members specific proteins human spliceosome contains proteins lack obvious orthologs yeast including specific proteins apart prp snu conversely tri snrnp protein spp one five cerevisiae splicing factors without known human ortholog results using inparanoid state art method ortholog inference pairs species systematic blast searches identified human specific protein mfap putative ortholog cerevisiae tri snrnp protein spp bioinformatics revealed mfap spp share characteristic structural features including intrinsic disorder elongated shape solvent exposure residues trend adopt alpha helical structures vitro binding studies showed human mfap yeast spp bind respective prp proteins via equivalent interfaces cross interact prp proteins respective species furthermore mfap spp form higher order complexes additionally include snu suggesting parts equivalent spliceosomal sub complexes finally similar yeast spp human mfap partially rescued growth defect temperature sensitive mutant yeast strain prp conclusions human specific protein mfap structurally functionally resembles yeast tri snrnp specific protein spp thus qualifies far missing ortholog study indicates yeast snu prp spp triple complex evolutionarily reprogrammed tri snrnp specific module yeast specific snu prp mfap module metazoa affording higher flexibility spliceosome assembly thus presumably splicing regulation
early detection decalcification vital osteoporosis diagnosis treatment since calcium ions main factor bone strength decalcification degrees bone classified assessment variation mechanical response applied load paper innovative non radiation low cost method proposed assessment bone decalcification capable discrimination low grade decalcification capability due employment high resolution fiber optic sensor fos strain sensitivity epsilon detects decalcification measurement strain induced loading sensor design procedure based genetic algorithm means mode field diameter mfd variation sensor indirect parameter common problems intensity modulated optical sensors overcome moreover sensor operation nearly independent temperature variation compensation requirement removed elsevier ltd rights reserved
digestion red processed meat linked formation genotoxic nitroso compounds nocs lipid peroxidation products lpos gut study rats fed meat based diet compare possible genotoxic effects red white meat interfering role dietary fat purpose liver duodenum colon dna adductomes analyzed uhplc hrms results demonstrate consumed meat type alters dna adductome levels different dna adduct types significantly increased upon consumption beef compared chicken lard supplemented beef chicken furthermore chemical constitution retrieved dna adducts hint direct link increase nocs lpos upon red processed meat digestion supporting current hypotheses causal link red processed meat consumption development colorectal cancer elsevier ltd rights reserved
purpose propose assess reproducibility new method glenoid orientation index estimation glenoid orientation relation anterior surface glenoid methods retrospective study computed tomography scan index defined angle formed line perpendicular tangent anterior surface scapula glenoid line defined line connecting anterior posterior rim glenoid measurements performed level glenoid diameter greatest two independent observers performed measurement twice intra inter observer reproducibility evaluated pearson coefficient intra class correlation coefficient rho icc correlation index glenoid version described friedman also studied results seventy eight scans analysed shoulders glenohumeral arthritis healthy shoulders females males mean age years measures highly correlated intra inter observer reproducibility good excellent rho index degrees degrees group glenohumeral osteoarthritis degrees healthy group glenoid version degrees group glenohumeral osteoarthritis degrees healthy group agreement found glenoid version index conclusions index simple reproducible could useful pre operative planning intra operative positioning implants total shoulder arthroplasty
investigated whether attachment quality related infant mother dyadic patterns monitoring animated social situations sixty month old infants mothers participated eye tracking study watched abstractly depicted distress interactions involving separation baby parent character followed reunion separation two characters measured infants mothers relative fixation duration two characters animations found infant attachment disorganization moderated correspondence monitoring patterns infant mother dyads final part animations resulting reunion separation organized infants mothers showed complementary monitoring patterns mothers focused attention baby character infants focused attention parent character vice versa disorganized infant mother dyads showed opposite pattern although correlation nonsignificant mothers infants focused character attachment related differences nature synchrony attentional processes infants mothers suggest months dyads representations social situations reflect shared social emotional experiences
smart tourism chinese cities try provide tourists services businesses via smart phones article analyzes relationship smart tourism smart city explores architecture smart tourism system technology application supporting platform focuses solutions via smart phones discusses problems challenges future trends process developing smart tourism
theileria equi babesia caballi causative agents equine piroplasmosis affects equine production various parts world however safe effective drug currently available treatment dihydroorotate dehydrogenase dhodh fourth enzyme novo pyrimidine synthesis pathway known novel drug target several apicomplexan protozoan parasites study evaluated four dhodh inhibitors atovaquone atv leflunomide lfn brequinar breq hydroxy triazolo pyrimidine taz growth equi caballi vitro compared diminacene aceturate control drug growth equi caballi significantly hindered inhibitors except taz half maximal inhibitory concentration atv lfn breq equi approximately respectively whereas atv lfn breq caballi approximately respectively using bioinformatics western blot analysis showed tedhodh similar babesia parasite dhodhs confirmed targeting dhodhs could useful development novel chemotherapeutics treatment elsevier inc rights reserved
electrical power generation devices use lead zirconate titanate piezoelectric pzt elements developed convert structural vibration energy electrical energy reported effects vibration loads power generation characteristics pzt element doped niobium proposed use laminated pzt elements significantly improve power generation characteristics pzt elements paper describes experimental analytical study conducted clarify power generation characteristics laminated pzt element doped vibration loads experimental study effects number layers laminated pzt element loads frequencies vibration loads load resistances voltage measurement circuit power generation characteristics laminated pzt element evaluated vibration tests analytical study theoretical formulas power generation characteristics pzt element vibrational loads derived considering equivalent circuit model consisting laminated pzt element load resistances voltmeter addition experimental results generated voltage electric power laminated pzt element compared analytical values using theoretical formulas validity power generation theory laminated pzt elements vibrational loads evaluated experimental results confirmed laminated pzt element dramatically improve power generation characteristics electrical generator using pzt elements power generation characteristics laminated pzt element depend largely number layers pzt element loads frequencies vibrational loads resistances measurement circuit analytical results validity power generation theory laminated pzt elements vibrational loads confirmed comparison experimental results analytical results
paper consider number protected nodes random digital trees results mean variance number tries obtained gaither gaither ward mean digital search trees prodinger short note show previous results extensions variance digital search trees limit laws cases derived systematic way recent approaches fuchs fuchs lee interestingly results moments obtain approach quite different previous ones contain divergent series values appealing theory abel summability also show tools apply patricia tries number protected nodes investigated far elsevier rights reserved
signs symptoms atopic dermatitis safely effectively controlled patients many cases disease improved point signs symptoms absent minimal addition flares effectively controlled cases prevented new topical medications improved strategies use topical corticosteroids topical calcineurin inhibitors judicious use nonpharmacologic regimens including bathing bleach baths early use emollients led better disease management improved quality life patients families published frontline medical communications
certain types variation licenced phonotactics example american english phoneme varies word finally similar word initially used deese roediger mcdermott false memory paradigm pursue hypothesis given comparable information speech stream varying words bat activate less strongly non varying words tip presented listeners lists phonological neighbours rat ban bet etc neighbours bat lip tin type etc neighbours tip followed recall recognition tasks results showed participants often remembered unheard words bat tip replicating previous work indicating activation neighbours produce false memories importantly false memory rates significantly lower bat compared tip suggesting presence phonotactic conditions variability affected lexical activation word compared absence conditions
characterised increased spread technology workplaces public spaces homes called third wave human computer interaction placed greater focus scenarios socially situated context dependent necessarily task oriented movement led studies investigating people interact digital applications public spaces discussion intuitive interaction thus far extended new realm user interfaces designing intuitive interaction public spaces differs traditional digital applications due inherently fluid social nature often large scale character urban interventions article discusses design interaction public spaces based applications developed along years contrasted similar endeavours elsewhere analyse lens frameworks intuitive interactions derive series strategies towards designing immediate use high crowd turnaround urban interventions
objectiveextant literature documented significant relationship borderline symptoms substance use disorders supported past work significant theoretical relationship borderline symptoms compulsive sexual behaviors disorders share common underlying behaviors traits known research examined empirical relationship borderline symptoms compulsive sexual behaviors population substance use disorders fill important gap literature relationship examined current study methodmedical records women admitted private residential treatment program substance use disorders reviewed current study resultshierarchical multiple regression analysis demonstrated borderline symptoms significantly associated compulsive sexual behaviors controlling alcohol use problems drug use problems age positive impression management conclusionresults study provide potentially important research clinical implications could ultimately aid treatment reduce relapse however continued research needed examine relationship symptoms compulsive sexual behaviors
nowadays introduction application new information technologies manufacturing various advanced manufacturing modes national strategies put forward paid attention industry industrial internet cyber physical system cyber manufacturing made china internet plus manufacturing cloud manufacturing etc modes strategies realize effective intelligent supply demand matching sdm various manufacturing resources capabilities form service one common issues aims order provide uniformed research platform related researchers academic industry concept manufacturing service sdm simulator sdmsim proposed paper hypernetwork based architecture simulator designed well seven key functions subsystems including manufacturing service management manufacturing task management manufacturing service sdm hypernetwork manufacturing service sdm problem formulation configuration matching scheduling algorithms strategies selection design statistical analysis visualization illustrates sdmsim potential serve users manufacturing service provider manufacturing service consumer manufacturing service operator field som well related researchers elsevier ltd rights reserved
objective brain computer interfaces bcis help patients lost control muscles still conscious able communicate interact environment one popular types bci based bci bci users asked count number appearances target stimuli experiment date majority visual based bci systems developed used character picture target every stimulus presentation bore users consequently users attention may decrease negatively affected adjacent stimuli approach study new stimulus presented increase user concentration honeycomb shaped figures red dots used stimuli number positions red dots honeycomb shaped figure randomly changed bci control user asked count number dots presented flash instead number times flashed assess performance new stimulus another honeycomb shaped stimulus without red dots used control condition main results results showed honeycomb shaped stimuli red dots obtained significantly higher classification accuracies information transfer rates compared honeycomb shaped stimulus without red dots significance results indicate proposed method promising approach improve performance bci system efficient method daily application
narrative review considers key challenges facing healthcare professionals policymakers responsible providing care populations relation bone health challenges broadly fall four distinct themes case finding management individuals high risk fracture public awareness osteoporosis fragility fractures reimbursement health system policy epidemiology fracture developing world findings cohort studies randomised controlled trials systematic reviews meta analyses addition current clinical guidelines position papers national international audits summarised intention providing prioritised approach delivery optimal bone health systematic approaches case finding individuals high risk sustaining fragility fractures described include strategies models care intended improve case finding individuals sustained fragility fractures undergoing treatment medicines adverse effect bone health people diseases whereby bone loss consequently fragility fractures common comorbidity approaches deliver primary fracture prevention clinically effective cost effective manner also explored public awareness osteoporosis low worldwide older people pro active management bone health needs change effective disease awareness campaigns implemented countries need undertaken many major need exists improve awareness risk osteoporosis poses individuals initiated treatment intention improving adherence long term multisector effort also required support patients clinicians meaningful discussions concerning risk benefit ratio osteoporosis treatment regard prioritisation fragility fracture prevention national policy much done developing world robust epidemiological estimates fracture incidence required inform policy development aging baby boomer generation upon review provides comprehensive analysis bone health improved worldwide
new hysteresis window method proposed solution avoiding operational dead zone exists transition buck boost operating modes noninverting buck boost converters addition method also eliminates discontinuities converter steady state output voltage transfer characteristic function duty cycle converter output voltage function surjective therefore smooth mode transitions achieved negative effects operating within dead zone shown presence subharmonics output voltage increased output voltage ripple poor regulation instability converter transition buck boost operating modes dead zone avoidance technique proposed paper eliminates issues time ensures highly efficient operation converter additional advantage technique simplicity allows implementation low cost digital signal controllers well analog control circuits advantageous features proposed approach evaluated basis comparisons three dead zone avoidance approaches initial case utilize dead zone avoidance technique experiments carried purpose built prototype noninverting buck boost converter magnetically coupled inductors
context emergency contraception widely used prevent unwanted pregnancy largely adopted many countries counter drug improve access aims determine compare correct knowledge attitude current use among newly graduated medical doctors mds settings design cross sectional study conducted among newly graduated mds university college hospital ibadan nigeria materials methods pretested self administered questionnaire used obtain data consenting participants statistical analysis used descriptive bivariate multivariable analyses performed statistical significance set statistical package social science version chicago usa software used results mean age respondents years standard deviation commonest indication emergency contraceptive use mentioned rape support nigeria quarter routinely counsel women ecp use respondents currently use logistic regression analysis revealed significant results gender odds ratio confidence interval religion marital status conclusion correct knowledge professional disposition toward form contraception low recommend service training focus improve quality knowledge attitude towards
dysregulated proteostasis key feature variety neurodegenerative disorders alzheimer disease progression symptoms closely correlates spatiotemporal progression tau aggregation early oligomeric tau forms rather mature neurofibrillary tangles nfts considered pathogenetic culprits ubiquitin proteasome system ups controls degradation soluble normal abnormally folded cytosolic proteins ups affected identified genomewide association study gwas risk pathway ups determined balanced regulation ubiquitination deubiquitination work performed isobaric tags relative absolute quantitation itraq based tau interactome mapping gain unbiased insight tau pathophysiology identify novel tau directed therapeutic targets focusing tau deubiquitination identify otub tau deubiquitinating enzyme otub directly affected lys linked tau deubiquitination impairing tau degradation dependent catalytically active cysteine independent noncanonical pathway modulated terminal domain primary neurons otub strongly increased positive tau oligomeric tau forms increased tau seeded tau aggregation primary neurons finally demonstrated expression otub catalytically inactive form induced pathological tau forms months tau transgenic mice vivo including positive tau oligomeric tau forms taken together identified otub tau deubiquitinase vitro vivo involved formation pathological tau forms including small soluble oligomeric forms otub particularly otub inhibitors currently development cancer therapies may therefore yield interesting novel therapeutic avenues tauopathies
new queensferry crossing near edinburgh scotland cable stayed bridge total length three towers high two cable supported main spans two back spans approach viaducts end variable spans two cable planes arranged centrally carriageways overlap centre main spans special feature necessary order stabilize deck especially centre tower unique design features world longest pair free standing cantilevers overall length constructing works exposed location experiencing adverse weather conditions put high demands engineers workers involved scale complexity new structure makes special even experienced bridge engineers also proximity two existing bridges firth forth forth rail bridge opened awarded world heritage site status summer lies alongside forth road bridge large suspension bridge opened completion queensferry crossing bridges representing engineering expertise three different centuries form unique collection iconic structures paper summarizes challenges design construction outstanding bridge
scope study evaluate vulnerability brazilian youths stds hiv aids viral hepatitis interviews conducted youths aged states federal district regional national adjusted margin error research study approved school medicine brasilia university support paho ministry health scale questions knowledge attitudes practices main dependent variable adjusted linear regression models identified demographic social determinant factors explain scale variations scale attained satisfactory level consistency cronbach alpha socio demographic factors associated scale variations include gender race education civil status social determinants associated scale variations include frequency discussions sexuality parents health professionals alcohol consumption leisure part social movement access internet interest learning father teacher personal reference brazilian youths vulnerable transmission stds hiv aids public policies needed promote engagement parents teachers issues related sexuality
purpose purpose paper present results practical experience cold starting gasoline engine low volatility fuel suitable unmanned aerial vehicle uav deployment design methodology approach experimental research development carried via dynamometer testing systems capable achieving cold start spark ignition uav engine kerosene jet fuel findings repeatable cold starts satisfactorily achieved ambient temperatures degrees approximate threshold warm engine restart also established practical implications safety supply logistical reasons elimination use gasoline fuel offers major advantages uavs also internal combustion engine powered equipment operated military theatres operation gasoline crankcase scavenged two stroke cycle engines presents development challenges terms modification lubrication strategy achieving acceptable performance characteristics ability successfully secure repeatable engine cold start originality value majority uavs still operate gasoline based fuels successful modification allow low volatility fuel operation would address single fuel policy objectives
background dearth literature examining causes cam type femoroacetabular impingement fai morphology appears purpose current study analyze ossific portion proximal femur develops time respect standard cam type fai parameters methods collection femurs cadavers aged years evaluated age sex ethnicity status proximal femoral physes open closed recorded specimen digitally photographed standardized anteroposterior modified axial positions photographs anterior offset anterior offset ratio aor alpha angle determined cam lesion defined alpha angle degrees lateral view results mean age specimens years majority male african american closed physes significant differences among discrete age groups respect alpha angle anterior offset aor addition younger femurs open physes significantly higher mean alpha angle lower mean anterior offset higher mean aor compared older ones closed physes specimens defined cam deformity statistically higher alpha angle lower anterior offset difference aor values compared specimens without cam lesion conclusions apparent decline alpha angles age increases indicates traditional alpha angle younger patients measures different anatomic parameter ossified femur excluding cartilaginous portion older patients completely ossified femur suggests bony alpha angle inappropriate evaluation cam lesions immature physis aor rather anterior offset may accurate evaluation growing proximal femur clinical relevance study provides novel insight enhances understanding development cam type fai
two experiments examined veridical false memory lists associates two meanings stumble trip harvest pumpkin etc converged upon single lexically ambiguous critical lure fall order compare activation monitoring fuzzy trace false memory accounts experiment presented study lists blocked alternated meaning within subjects followed free recall test completed immediately min delay correct recall greater blocked alternated lists critical lure false recall greater blocked lists immediate test whereas list types produced equivalent false recall delayed test experiment lists blocked alternated meaning presented via subjects design order eliminate possible list type carryover effects correct recall replicated result experiment however blocking lists increased false recall delayed immediate tests across experiments clustering correct recall meaning increased across delay selectively alternated lists results suggest thematic gist processes influential false recall especially following delay pattern consistent fuzzy trace theory
development wireless vehicular hoc network vanet aimed enhance road safety provide comfortable driving environment delivering early warning infotainment messages intentional jamming attacks target undermining goal disrupting wireless communications detecting jamming attacks important towards enhancing road safety challenging vanet operates outdoor environment highly changeable road conditions atmospheric phenomena encompasses volatile topology high mobility vehicles traveling speed directions overcome challenges work study jamming attack mobility behaviors ieee networks particular focus analyzing jamming impact based jammers behaviors mobility patterns thus order achieve reliable detection first identify impact vehicles density network performance study jamming effectiveness adopting different mobility patterns stationary random targeting behaviors constant random reactive finally propose two phase detection algorithm evaluate simulation environment approach shows promising results detect different types jammers accurately ieee networks
widespread utilization mobile hoc networks communicate via broadcast wireless channels without sort infrastructure raises security concerns introduction identity based cryptography shed light security problems mobile hoc networks key management plays significant role network security although many proposals suggested identity based usually assume trusted set nodes network initialization case many real world applications paper novel identity based method proposed utilizes pedersen verifiable secret sharing method distributing shared secret key generation role among network nodes proposed method provides high levels availability scalability eliminating single point failure proposed method provides mechanism check validity secret shares generated network nodes illustrate effectiveness capabilities proposed methods simulated compared performance existing methods copyright john wiley sons ltd
high variability solar energy makes utility scale photovoltaic power generation confront huge challenges penetrate power system paper complementary hydro photovoltaic operation explored aiming improving power quality photovoltaic promoting integration photovoltaic system first solar rich hydro rich regions across world revealed suitable implementing complementary hydro photovoltaid operation three practical scenarios novel operation mode proposed better satisfying different types load demand moreover method optimal sizing photovoltaic plant integrated hydropower plant developed maximizing net revenue lifetime longyangxia complementary hydro photovoltaic project current world largest hydro photovoltaic power plant selected case study optimal photovoltaic capacities different scenarios calculated results indicate hydropower installed capacity annual solar curtailment rate play crucial roles size optimization photovoltaic plant complementary hydro photovoltaic operation exerts little adverse effect upon water resources allocation longyangxia reservoir novel operation mode improves penetration utility scale photovoltaic power generation also provide valuable reference large scale utilization kinds renewable energy worldwide elsevier ltd rights reserved
terms psychopath sociopath often used interchangeably appears hesitance researchers many disciplines comprising criminology continue trend problem seems research advanced studies psychopathy common two terms psychopathy commands much specific definition alienates estranged cousin sociopathy language serve hinder confound research crucial terms take proper place brain science present two terms currently used neuroscience psychology suggest research sociopathy progress elsevier ltd rights reserved
many adults intellectual developmental disabilities idd access health long term services supports ltss medicaid states reforming medicaid ltss programs fee service model medicaid managed ltss mltss approach anticipating improved quality care reduced costs although limited evidence mltss effectiveness study objective contribute growing mltss research literature describing mltss implementation kansas adults idd thirty one stakeholders completed depth semi structured interviews representing state regional groups service coordination providers family caregivers findings identify key aspects centers medicare medicaid services new mltss regulations design implementation mltss programs
variety contraception options available addition traditional combined oral contraceptive pills newer long acting reversible contraceptive larc methods intrauterine devices subcutaneous implants preferred depend patient compliance highly effective appropriate women female male sterilization effective irreversible require counseling minimize regret contraceptive injection patch ring require daily administration typical efficacy rates lower larc methods similar combined oral contraceptive pills
distribution transmission electric power companies many losses risks associated corrosive processes occur buried structures tower leg foundations overhead transmission lines tower leg corrosion control foundation involves collection analysis data generated different inspection methods practices routine maintenance repair aim paper demonstrate methodology developed identify locations towers susceptible high rates metal corrosion foundation tower legs order facilitate better maintenance planning evaluate failure risks assets end using delphi methodology variables affect corrosion phenomenon correlated geographic information generate algebraic maps advanced analysis despite difficulty searching correlating georeferenced data results interesting promise possibilities future applications
purpose review review presents cutting edge methods current forthcoming satellite remote sensing technologies map aboveground biomass agb recent findings monitoring carbon stored living agb forest key importance understand global carbon cycle functioning international economic mechanisms aiming protect enhance forest carbon stocks main challenge monitoring agb lies difficulty obtaining field measurements allometric models several parts world due geographical remoteness lack capacity data paucity armed conflicts space borne remote sensing combination ground measurements cost efficient technology undertake monitoring agb summary approaches face several challenges lack ground data calibration validation purposes signal saturation high agb coverage sensor cloud cover persistence complex signal retrieval due topography new space borne sensors launched coming years allow accurate measurements agb high biomass forests first time across large areas
ultimate goal engaged research develop implantable medical devices develop mechatronic implantable artificial organs artificial pancreas devices would comprise least sensor module actuator module controller module development optimal mechatronic implantable artificial organs modules self powered autonomously operated study aimed develop microcontroller using biocapacitor principle direct electron transfer type glucose dehydrogenase immobilized onto mesoporous carbon deposited surface miniaturized electrode prepare miniaturized enzyme anode enzyme fuel cell connected capacitor power boost converter charge pump voltage enzyme fuel cell increased stepwise manner charge pump generated electricity charged capacitor charge pump circuit connected ultra low power microcontroller thus prepared biocapacitor based circuit able operate ultra low power microcontroller continuously running program turned led every success operating microcontroller using glucose sole energy source indicated probability realizing implantable self powered autonomously operated artificial organs artificial pancreas
background breast cancer common malignancy remains leading cause cancer related deaths female chemotherapy failure breast cancer mainly associated multidrug resistance cancer cells purpose wga modified daunorubicin anti resistant liposomes developed circumventing multidrug resistance eliminating cancer cells methods wga modified liposomal surface increasing intracellular uptake tetrandrine inserted phospholipid bilayer reversing cancer drug resistance daunorubicin encapsulated liposomal aqueous core anticancer agent evaluations performed mcf cells mcf adr cells xenografts mcf adr cells results vitro results showed wga modified daunorubicin anti resistant liposomes exhibited suitable physicochemical properties significantly increased intracellular uptake mcf cells mcf adr cells circumvented multidrug resistance via inhibiting vivo results demonstrated targeting liposomes showed long circulatory effect blood system could remarkably accumulate tumor location involved action mechanisms enhanced anticancer efficacy activation pro apoptotic proteins bax bok apoptotic enzymes caspase caspase caspase conclusion established wga modified daunorubicin anti resistant liposomes could provide potential strategy treating resistant mcf breast cancer
digital content makes improvement learning transferring knowledge learners learning delivers digital contents learners learn anywhere anytime educators deliver materials interactive way digital content becomes important improving self learner understanding computer programming experimental design method using control group pretest posttest conducted compare digital contents effectiveness learning outcomes computer programming field self learning students instrument used programming case factor level tested various digital content types desired response learning outcomes increment study concludes average increment learning outcomes using various digital contents self learning still lower average increment compared traditional classroom method results study recommendation educators students applying determining use digital contents self learning
background psychological effects air ions reported years media scientific literature study summarizes qualitative literature review quantitative meta analysis applicable examines potential effects exposure negative positive air ions psychological measures mood emotional state methods structured literature review conducted identify human experimental studies published august thirty three studies evaluating effects air ionization depression anxiety mood states subjective feelings mental well humans included five studies negative ionization depression measured using structured interview guide evaluated level exposure intensity high low using meta analysis results consistent ionization effects observed anxiety mood relaxation sleep personal comfort contrast meta analysis results showed negative ionization overall significantly associated lower depression ratings stronger association observed high levels negative ion exposure mean summary effect confidence interval following high low density exposure respectively response high density ionization observed patients seasonal chronic depression effect low density ionization observed patients seasonal depression however relationship duration frequency ionization treatment depression ratings evident conclusions consistent influence positive negative air ionization anxiety mood relaxation sleep personal comfort measures observed negative air ionization associated lower depression scores particularly highest exposure level future research needed evaluate biological plausibility association
racial resentment shown significant impact voting whites recent presidential elections much larger impact traditional gender gap measure based male female dichotomy analysis use data american national election studies anes compare broader indicators race gender applicable democratic republican parties well respondents opinions appropriate roles women since parties diverged considerably abortion women issues voters view democrats supportive republicans equality women reproductive rights perceptions party differences women issues strongly influenced vote choice greater impact whites votes opinions aid blacks abortion gay marriage economy although racial resentment strong predictor white vote previous years presidential voting also significantly influenced respondent sex well opinions gender roles voters regarded democratic party better interests women proved highly effective wedge issue democrats
background mentalization based treatment mbt promising though expensive treatment severely ill patients borderline personality disorder bpd high burden disease terms quality life qol life years lost reason prioritize mental health interventions specifically bpd patients moreover societal costs illness high spending resources high treatment costs would easily legitimized therefore purpose study calculate burden disease bpd patients eligible mbt methods patients included study recruited two mental health care institutes netherlands patients eligible mbt burden disease consisted qol measured euroqol costs calculated using trimbos institute medical technology assessment questionnaire costs associated psychiatric illness results mean qol index score mean total costs year prior treatment sic per patient consisted productivity costs conclusions burden disease bpd patients eligible mbt high makes likely society willing invest treatment patients however finding interpreted license unlimitedly use resources reimburse treatment severe bpd patients findings provide information effectiveness mbt available treatment programs bpd effectiveness available treatments evident studies effectiveness treatment comparing effectiveness treatments treatment usual treatment options bpd patients
present research focuses improvement various soil properties strength parameters clayey subgrade using geogrid biaxial geotextile nonwoven placed various reinforcement systems viz single layer reinforcement system sil composite layer reinforcement system col multi layer reinforcement system various position levels subgrade thickness high strength geotextile biaxial geogrid used geosynthetic reinforcement materials study soaked unsoaked cbr tests performed expansive soil soil using mentioned reinforcement systems main objective study know efficient geosynthetic reinforcement system position reinforcement medium expansive soil highly expansive soil gujarat region given results depicts infusion geosynthetic reinforcement various levels subgrade note improves cbr value overall increases structural stability subgrade various subgrade systems composite reinforced system position gave maximum cbr value calibration modulus subgrade reaction quite compatible
objective compare metabolic profiles normo hyperandrogenic women polycystic ovary syndrome pcos control women different ages reproductive life design case control study setting applicable patient women normoandrogenic hyperandrogenic pcos control women divided three age groups years interventions none main outcome measure body mass index bmi waist circumference blood pressure glucose insulin cholesterol lipoproteins triglycerides high sensitivity reactive protein result normo hyperandrogenic women pcos obese especially abdominally increased serum levels insulin fasting oral glucose tolerance tests triglycerides low density lipoprotein total cholesterol higher blood pressure lower high density lipoprotein levels independently bmi compared control population early young adulthood menopause prevalence metabolic syndrome two fivefold higher women pcos compared control women depending age phenotype highest prevalence observed hyperandrogenic women pcos late reproductive age conclusion evaluating metabolic risks women pcos androgenic status especially abdominal obesity age taken account would allow tailored management syndrome early adulthood american society reproductive medicine
age related male hypogonadism andropause increasingly recognized frequent occurrence older patients diagnosis requires presence clinical symptoms low testosterone levels however diagnosing andropause age group may challenging since symptoms frequently non specific testosterone levels influenced multitude parameters lifestyle factors chronic diseases article discuss pathophysiology definition diagnostic difficulties andropause geriatric patients moreover review relation testosterone levels frequent geriatric syndromes falls osteoporosis cognitive mood disorders anemia cardiovascular disease finally examine potential benefits risks testosterone replacement therapy age group elsevier ireland ltd rights reserved
paper describes distributed maximum power point tracking control scheme photovoltaic systems submodule level system employs isolated differential power processing dpp converters require perturb observe synchronization little communication among power converters design benefits architecture respect control communication converter efficiency analyzed isolated converter prototypes constructed employed within string series connected submodules experimentally validate proposed control method experimental extraction efficiency achieved three submodule connection similar mismatch improvement conventional non dpp architecture
background large geographical gaps knowledge prevalence burden headache disorders include almost eastern mediterranean region emr report nationwide population based study pakistan emr country sixth largest population world conducted project within global campaign headache methods surveyed six locations four provinces pakistan punjab sindh khyber pakhtunkhwa baluchistan randomly selected visited rural urban households one adult member years household also randomly selected interviewed trained non medical interviewer location using previously validated structured questionnaire translated urdu national language estimated year prevalences headache disorders public health importance examined associations demographic variables using multivariate analysis results participants mean age years male female urban rural participation proportion headache previous year reported age gender adjusted year prevalence migraine male female tension type headache tth male female probable medication overuse headache male female headache days month male female migraine prevalent females factor although association barely survived correcting factors tth prevalent males headache migraine age related peaking age group years tth peaked decade earlier higher education income negatively associated prevalence migraine conclusion three quarters population affected headache disorders must public health agenda pakistan worldwide disorders third leading cause disability information specific enquiry burden attributable headache disorders country needed inform health policy priority setting reported soon
objective purpose study determine effect adjuvant light therapy antipsychotic treatment patients delirium methods thirty six patients referred consulting psychiatry division hospital disturbance consciousness patients randomized risperidone risperidone light therapy evaluated day baseline days delirium rating scale drs memorial delirium assessment scale mdas sleep parameters measured using sleep log results mean drs mdas scores decreased significantly time treatment groups risperidone light therapy group showed significantly greater decrease drs score risperidone group mdas score significantly different two groups significant improvement total sleep time sleep efficiency risperidone light therapy group risperidone group conclusions results indicate risperidone light therapy may helpful adjuvant treatment patients delirium adequately powered studies head head comparison design mandatory confirm findings elsevier inc rights reserved
background previous studies shown personality characteristics affect sexual functioning aim exploratory study assess describe relationship global personality traits stereotypical femininity masculinity levels broad aspects sexual behaviours attitudes group heterosexual young adult men aged living poland methods big five personality traits measured neo ffi questionnaire stereotypical femininity masculinity bem sex role inventory bsri sexual disorders international index erectile function iief socio epidemiological data sexual behaviours attitudes towards sexuality self constructed questionnaire results identified weak moderate associations particular sexual behaviours attitudes neuroticism correlated positively lower sexual satisfaction self acceptance negative attitudes towards sexuality extraversion higher desire frequency sexual intercourses diversity sexual satisfaction masculinity level lower report erectile problems openness experience better quality partnership positive attitudes towards sexual activity masculinity level conscientiousness later sexual initiation age frequent diverse sexual behaviours lower interest masturbation coitus interruptus overall sexual satisfaction satisfaction one body femininity level agreeableness better quality relationship partner satisfaction body lower number previous partners frequent sexual encounters less masturbation stereotypical masculinity femininity related wide range positive aspects sexuality conclusions big five personality traits stereotypical femininity masculinity dimensions found noticeable weak moderate influence sexual behaviour young adult males
paper describes use cyberinfrastructure create interactive applications part useful usable project applications transform historical climate data knowledge models decision support tools end users crop farmers university extension educators agricultural advisors creating cyberinfrastructure support project four major challenges addressed designing developing highly usable web applications frequent feedback establishing software engineering environment support iterative development integrating synthesizing historical current datasets variety sources local remote different access methods formats supporting project collaboration needs data document sharing project management public outreach overall goals cyberinfrastructure architecture design described methods data retrieval synthesis well various software components utilized discussed development integration tools collaborative hubzero framework highlighted including use hubzero core features share ideas algorithms results highly iterative development process includes feedback experts end users feed requirement definition design application updates also examined authors published elsevier open access article license
objective randomized controlled trial rct aimed evaluate efficacy internet based stress management intervention ismi among employees compared month waitlist control group wlc full access treatment usual method sample employees elevated symptoms perceived stress perceived stress scale pss assigned either ismi wlc group ismi consisted seven sessions one booster session including problem solving emotion regulation techniques participants received guidance coach focused improving adherence intervention self report data assessed baseline seven weeks six months following randomization primary outcome perceived stress pss secondary outcomes included relevant mental work related health outcomes results ismi participants showed significantly higher reduction perceived stress baseline seven weeks confidence interval month follow compared controls significant moderate large effect sizes also found depression anxiety emotional exhaustion sleeping problems worrying quality life mental health psychological detachment emotion regulation skills work engagement quality life physical health absenteeism presenteeism found significantly differ ismi wlc groups changes emotion regulation regarding general distress mediated changes perceived stress conclusion ismi investigated study found effective reducing typical symptoms stress however several important work related health symptoms significantly affected intervention internet based guided self help interventions could acceptable effective approach reduce range negative consequences associated work related stress future studies investigate comparative cost effectiveness guided unguided stress management interventions
objectives based trait activation principle researchers tested whether personality traits capable predicting sport performance pressure typically however investigations followed experimental approaches laboratory rarely field accordingly purpose study test generalizability findings gained experimental studies investigate potential trait activation real world performance competitions based prior studies prediction performance pressure selected personality traits involved fear negative evaluation dispositional reinvestment athletic identity design personality traits used predictors low pressure high pressure basketball free throw performance method first basketball players completed trait questionnaires second directly prior performance assessments participants reported perceived importance somatic cognitive state anxiety confidence third free throw performance assessed low pressure condition successful free throw percentage attempts repeatedly high pressure conditions within real basketball matches successful free throw percentage total attempts results two main findings identified first none traits predicted performance low pressure second high pressure fear negative evaluation well state anxiety significantly negatively associated performance competitions conclusion results extend existing literature add applied ecologically valid empirical support relevance anxiety related traits fear negative evaluation states performance pressure real world competitions emphasizing importance self presentational considerations athletes stakes high elsevier ltd rights reserved
since beginning industrial revolution manufacturing industries primarily responsible adverse effects environment caused pollutants carbon dioxide therefore tremendous pressure industries globally competitive within range environmental regulations laws greatly increased reinforced days addition manufacturing industries confronted new challenges owing depletion energy natural resources economic stagnation increasing human needs become diverse thus low carbon green growth cleaner production eco friendly products main issues sustainable manufacturing driving direction future manufacturing industry plm product lifecycle management one innovative manufacturing paradigms leverage business technologies order allow company product content developed integrated company business processes extended enterprise paper designed new information model plm system sustainable manufacturing using uml methodology performed thoughtful analyses existing plm sustainable indicator basic schema information model supporting sustainable manufacturing engineering developed paper also presents apractical case study showing information model sustainable engineering using commercial pdm software
systems modelling fusion power plants essential robustly predict performance given machine design including respective operating scenario one measure machine performance energy confinement time tau typically predicted experimentally derived confinement scaling laws ipb however conventionally used scaling laws derived iter unlike fusion power plant significant radiation inside separatrix absence new high core radiation relevant confinement scaling propose hoc correction loss power used iter confinement scaling calculation stored energy radiation losses core plasma rad core using detailed astra tglf simulations find appropriate definition rad core given radiative losses inside normalised minor radius rho core consider improvement current design predictions far ideal solution therefore encourage detailed experimental theoretical work issue
incomplete information studied depth relational databases knowledge representation context web incomplete information issues studied detail xml papers exist rdf paper make first general proposal extending rdf ability represent property values exist unknown partially known using constraints following ideas incomplete information literature develop semantics extension rdf called rdfi study query evaluation sparql transfer concept representation systems incomplete information relational databases case rdfi identify two important fragments sparql used define representation system rdfi first corresponds monotone fragment graph patterns uses operators union filter second corresponds well designed graph patterns fragment uses operators filter opt enjoys interesting properties make query evaluation efficient prove two fragments used define representation system construct queries without blank nodes templates also define fundamental concept certain answers sparql queries rdfi databases present algorithm computation present complexity results computing certain answers considering equality temporal spatial constraint languages class construct queries representation systems finally demonstrate usefulness rdfi geospatial semantic web applications giving number examples comparing modeling capabilities rdfi related formalisms found literature elsevier rights reserved
modifying flow rule attack posts huge threat controllers network operating system nos software defined network sdn due concealment based previously proposed nos architecture multiple controllers introduce heterogeneity dynamic defend attack effectively dynamic segment dynamically scheduling controllers explicitly presented dynamic scheduling method put forward maximise security gain nos switch algorithm able improve nos security altering framework diversity maximum degree considering switching cost latency simultaneously theory analysis simulation results prove validity availability devised mechanism effective security performance traditional architectures
climate change mitigation requires shift fossil energy resources renewables bioenergy crops considered one major potential resources time future energy supplies expected sustainable sustainability energy crop production challenged concerns potential competition arable land disruption food feed markets protein plant biomass challenge sustainability also opportunity challenge protein disproportionately large land use foot print associated biosynthesis bioenergy exploits solar energy temporarily stored biomass compounds carbohydrate lipid lignin protein organic acids review energy cost estimates photosynthesis growth maintenance respiration show comparing energy costs amount energy stored different plant compounds protein conservation could improve sustainability energy crop production reducing land use impacts opportunity protein plant biomass comes fact favored energy crops like switch grass reed grass miscanthus excellent protein producers par soybean protein rich crops due scale potential future bioenergy deployment find energy strategies involving large amounts herbaceous energy crops sustainable unless proteins conserved way
binary euclidean algorithm modification classical euclidean algorithm computation greatest common divisors avoids ordinary integer division favour division powers two expectation number steps taken binary euclidean algorithm applied pairs integers bounded size first investigated brent via heuristic model algorithm random dynamical system based numerical investigations expectation associated ruelle transfer operator brent obtained conjectural asymptotic expression mean number steps performed algorithm processing pairs odd integers whose size bounded large integer vallee modified brent model via induction scheme rigorously prove asymptotic formula average number steps performed algorithm however relationship result brent heuristics remains conjectural article establish previously conjectural properties brent transfer operator showing directly possesses spectral gap preserves unique continuous density density shown extend holomorphically complex right half plane logarithmic singularity zero combining results methods classical analytic number theory prove correctness three conjectured formulae expected number steps resolving several open questions promoted knuth art computer programming author published elsevier inc
setback many projects face senior management fear well run project heading success take turn worst project manager replaced result resignation transfer replacement leader foundation project result poor management triple constraint scope time budget loss historical project information well cause ripple effect conflict confusion misunderstanding poor team spirit within project team term replacing project manager rpm easily recognized organizations yet little documentation available discussing common issue frequency replacement circumstances project manager replaced effect project execution investigated
chronic venous disease cvd common venous disease lower extremities patients often develop symptoms itching skin roughness easy use objective skin examination recently developed allows measurement level stratum corneum content transepidermal water loss tewl indicate status barrier function stratum corneum previous studies demonstrated histamine production mast cells tryptase matrix metalloprotease levels associated skin inflammation study aimed clarify relationship dry skin inflammatory mediators mediate skin symptoms cvd subjects study enrolled subjects cvd control group consisting volunteers itching onset frequency higher women compared men analyze mechanisms involved itching measured blood inflammatory mediators pre post sclerotherapy significant decrease substance histamine ige tryptase levels post sclerotherapy compared pre sclerotherapy levels associated severity itching addition compared control subjects significant increase stratum corneum water content decrease tewl patients cvd associated decrease itching symptoms findings indicate sclerotherapy decreased levels inflammatory mediators increased stratum corneum water content decreased tewl coincided reduced itching cvd patients indicating might therapeutic targets
objective investigate spectrum antibiotic resistant pattern risk factors outcomes infection patients hospitalized systemic lupus erythematosus sle methods collected clinical microbiological data hospitalized patients sle infection june june conducted retrospective analyses results among sample hospitalized patients diagnosed infection majority infection occurred within years sle onset bacterial infection predominant followed viral infection fungal infection lungs upper respiratory tracts commonly affected gram negative bacteria gnb predominant gram positive bacteria isolates isolates frequently isolated bacteria escherichia coli followed acinetobacter baumannii coagulase negative staphylococcus multidrug resistant mdr strains detected bacterial isolates common fungus candida spp episodes followed aspergillus episodes cryptococcus neoformans episodes overall mortality rate cohort patients died infection factors associated bacterial viral infection higher systemic lupus erythematosus disease activity index renal involvement thrombocytopenia accumulated dose glucocorticoids treatment cyclophosphamide cyc renal involvement accumulated dose treatment cyc associated fungal infection conclusion infection leading cause mortality patients hospitalized sle notable features infection chinese patients including early onset higher proportion respiratory tract involvement predominance gnb emergence mdr isolates variety pathogens
pipeline transportation plays important role resources deployment economic development country dimensional repair technique important guarantee ensure safety reduce loss tapping machine draws lot attention key equipment according project practice key problems largest diameter pipe tapping machine design manufacture country discussed firstly development status opportunities challenges analyzed requirements theory tapping machine design analyzed design features accessories control components finished problems tapping pressure pressure balance body seal remote control solved finally problems manufacturing process tapping machine like welding deep hole keyway long axis researched solutions put forward successful use machine shows usefulness reliability
aim study compare responsiveness two joint inflammation scoring systems dichotomous scoring versus semi quantitative scoring sqs using novel individualized ultrasound joint selection methods existing ultrasound joint selection methods responsiveness measured standardized response means srms using sqs system novel existing ultrasound joint selection methods derived using baseline month total inflammatory scores rheumatoid arthritis patients relative srm gain ratios srm gains scoring system sqs comparing novel existing methods computed scoring systems sqs demonstrated substantial srm gains ranged system ranged sqs system srms using novel methods ranged system ranged sqs system srms using existing methods ranged system ranged sqs system system appears achieve high responsiveness comparable sqs novel individualized ultrasound joint selection methods
alternative approach model mechanical behavior steel frames exposed fire high temperatures presented work concept based series stress strain curves obtained experimentally various temperature levels artificial neural network ann employed predict stress strain curve condition numerical results obtained anns stress levels material compared experimental data new model reduction factor introduced compared models using ann found efficient tool modeling material properties steel frames high temperature applications
paper note signature based intrusion detection system ids cause low accuracy mutants intrusion packets ids commonly detects network intrusion data flows identifying existence predefined intrusion signatures called static intrusion signature configuration sisc increase accuracy intrusion signatures corresponding possible mutants pertinent attack may activated however static intrusion signature configuration possible intrusion signatures largely increase size storage signature search time process signature analysis solve problems occur activating possible intrusion signatures propose two player non cooperative zero sum game incomplete information dynamic intrusion signature configuration disc various lengths intrusion signature activated time shared manner formulating problem game theoretic approach found optimal strategy disc ids best knowledge work first approach analyzes optimal disc strategy various mutants intrusion packets evaluation results show disc defender effective sisc various mutants intrusion packets intruder
background due heterogeneous nature schizophrenia understanding genetic risk disease complex task gene expression studies proven reliable association studies consistently replicated tissue specific manner methods using rna seq analysed gene expression frontal cortex individuals schizophrenia unaffected controls results identified genes differentially expressed schizophrenia approximately regulated also aberrant dna methylation chi differentially expressed genes significantly overrepresented several pathways including inflammatory chi nitric oxide pathways chi moreover genes significantly enriched druggable genome identified number genes significantly regulated schizophrenia confirmed gene expression studies using different brain tissues genes associated schizophrenia psychiatric genomics consortium identified genes significant list differentially expressed genes conclusions results identified biological functional genes differentially expressed schizophrenia subset genes clinically proven drug targets also found strong pattern differentially expressed immune response genes may reflect underlying defect schizophrenia crown copyright published elsevier inc rights reserved
study left atrial appendage laa structure morphology assessed using real time three dimensional transesophageal echocardiography rtd tee enhanced cardiac computed tomography scanning two measurements obtained using different techniques compared two hundred nonvalvular atrial fibrillation nvaf patients prepared undergo radiofrequency ablation enrolled controls enrolled prospectively rtd tee performed following parameters measured laa orifice diameter area depth maximum volume emptying velocity differences nvaf patients controls compared differences correlations laa parameters two imaging techniques assessed nvaf patients significantly bigger orifice sizes orifice areas maximum volumes lower emptying rates cohort roughly equal proportions four morphological types whereas controls predominantly windsock type bland altman analysis demonstrated laa measurements obtained using rtd tee lower obtained however linear regression analysis showed good correlations rtd tee measurements laa orifice area depth volume respectively use rtd tee visualization quantitative analysis laa parameters feasible obtained measurements correlate well obtained cardiac technique may ideal tool guiding laa occlusion procedures combining two methods may enhance accuracy laa measurements
delay one problems occurring owners contractors deviation base plans found using project control methods continuous assessment schedule determining progress percentages earned value parameters circumstances conflicts might arise contractor owner restoring project original schedule needs added expenditures contractor moreover continuation previous procedure late completion project cause owner damage research mathematical model using game theory presented model investigates behaviour strategies parties involved delayed project bargaining helps owners contractors gain deeper understanding given delay problem get fairly accurate analysis situation consider possible strategies facing circumstances without spending long inconclusive time points parties agree rationally proposed numerical example results model indicate parameters involved problem effective changing range width negotiation special cases disproportionate delay penalty parameters even make neutral negotiation step step analysis model showed features threaten negotiation
paper presents implementation fractional order pid pid controller using hardwired modules constant phase element cpe new approach phase shaping slope cancellation asymptotic phase plots zeros poles within given bandwidth realized analog circuits exhibit analog fractional order integrator fractional order differentiator used building pid controller design procedure developed obtain optimal pole zero pairs respective fractance components realize value fractional differ integrator cpe elements give minimum error tolerance set phase value using commercially available components amps pole zero location root locus plot constant asymptotic angle various feed forward gains achieved analog integrodifferential circuits pid iso damping feature controller practically demonstrated comparative performance demonstrated various settings feed forward gains indicate constant overshoot pid conventional pid circuits developed implemented motor emulator confirm designed performance controller
doped carbon materials great potential functional materials water pollution control however synthesis green sustainable doped carbon catalysts face numerous challenges study uses thermal treatment directly heating homogeneous mixture cobalt acetate dimethylglyoxime synthesize lamellar ordering coo compounds dimethylglyoxime chosen play duple roles nitrogen carbon source obtained doped carbon material used catalyst effective aniline degradation activating peroxymonosulfate pms approach nanomaterials good catalytic performance high stability magnetic property obtained facilitate recycle convenience study graphitic found improve electron mobility lone pair pyrrolic like electrons tends form effective moieties species increase catalyst activity therefore prepared catalyst higher activity individual coo furthermore effects doped carbon materials aniline degradation activated pms proposed reaction pathways mineralization aniline explain detailed elsevier rights reserved
studies examined early parenting among girls receiving child welfare services cws disentangled relationship maltreatment spending time foster care adolescent childbirth using population based linked administrative data study calculated birth rates among maltreated adolescent girls assessed differences birth rates associated spending time foster care girls substantiated allegations maltreatment adolescence nearly subsequently gave birth among girls spent time foster care proportion higher significant variations observed rate childbirth across demographic characteristics maltreatment experiences accounting covariates spending time foster care associated modestly higher rate first birth hazard ratio confidence interval age first substantiated allegation maltreatment race ethnicity significant predictors adolescent childbirth specific maltreatment experiences associated minimal differences birth rates findings study suggest experience spending time care may meaningful predictor giving birth teen among cws involved adolescent girls highlight subgroups population may vulnerable early childbirth
many research universities mechanical engineering curriculum include courses teach students essential professional knowledge needed become design engineer professional know regarded academic topic although mechanical designer get job industry need apply knowledge first day topics selecting mechanical elements motors bearings seals etc catalog selecting proper material coating designed part rarely taught even machine design courses believe mechanical engineering students learn practical skills get basic design experience close gap introduced new design manufacture laboratory senior undergraduate students paper describes laboratory course students activities design projects design projects performed lab follow learned design methodology include design reviews appropriate documentation designed systems produced assembled tested team addition learned technical skills soft skills taught lab related mechanical design include team work self management time management communication skills presentation skills soft skills essential tool every mechanical engineer starts work global changing industrial world authors published elsevier
national maternal mortality rate per live births clear becoming mother togo carries significant risk order inform scale maternal health services qualitative baseline evaluation explored barriers maternal reproductive health kozah district northern togo semi structured interviews community stake holders focus group discussions four groups six mothers inter related factors including financial means distance health posts gender roles cultural beliefs patient provider relations influence women care seeking behavior lack financial means renders cost crucial maternal health services prohibitive husbands resistance family planning health care financing compounds challenges women face meeting essential maternal health needs findings suggest waiving user fees providing facility based delivery free cost improving transportation options fostering trust access health centers could significantly improve maternal health kozah district
paper introduces highly flexible multichannel output stage battery powered portable electric stimulators ess based novel power converter architecture compared solutions presented output stage transcutaneous surface stimulations increases number applicable therapies improves battery operating time reduced power consumption potentially results comfortable shorter healing therapies new hybrid switch mode power converter combination flyback switched capacitor topologies flyback steps battery voltage provides galvanic isolation following power efficient stage replaces lossy linear current sources css conventional solutions produces pulses much higher slew rate reducing pulse energy needed cause stimulus also inherently produces pulses zero net charge eliminating bulky blocking capacitors dedicated discharging circuits regulation amplitudes pulses performed new digital voltage programmed current mode controller forcing output stage behave flexible digital controller allows creation various types pulses also features several levels patient protection experimental prototype output stage undergone proof principle tests able bodied individuals results show new output stage produces pulses slew rate two orders magnitude higher known solutions trials show faster slew rate pulses generate muscle contraction lower amplitudes reducing energy consumption allowing longer battery life portable applications
today high tech world amount data especially spatial data growing day day databases one best ways store data several database concepts exist storing data mostly used relational database concept relational databases well use storage geo non spatial data social media like facebook twitter relational databases often reach limit performance huge amounts data frequent data changes nosql databases used nosql databases used basis provision geo web service like wms wfs paper gives overview selected sql nosql databases according performance backend wms
lesbian gay bisexual transgender queer questioning lgbtq discrimination continues common college campuses number studies examined blatant victimization among students little attention given lgbtq microaggressions study examine blatant victimization microaggressions association psychological distress among lgbtq college students look whether gender identity moderates relationships forms discrimination associated lower self esteem greater stress anxiety victimization negatively associated self esteem among trans students findings emphasize importance addressing blatant subtle forms discrimination targeting lgbtq college students
one one tutoring human expert effective way novices overcome learning barriers complex domains computer programming usually far fewer experts learners enable single expert help learners built codeopticon interface enables programming tutor monitor chat dozens learners real time learner codes workspace consists editor compiler visual debugger tutor sees real time view learner actions dashboard learner workspace summarized tile glance tutor see learners editing debugging code errors encountering dashboard automatically reshuffles tiles active learners always tutor main field view tutor sees particular learner needs help open embedded chat window start one one conversation user study showed first time codeopticon users successfully tutored anonymous learners countries naturalistic online setting average minute session tutor monitored learners started conversations exchanged chats helped learners
relatively little research considering motivations passive facebook use however research regarding motivations general facebook use indicates people use facebook escape escapism may motivate passive facebook use research also suggests using facebook escape associated facebook addiction using experimental vignette design present research investigated whether passive facebook use motivated escapism whether escape motivation associated passive facebook addiction within participant experimental design using vignettes used explore effect positivity addition socialness passive facebook use addiction passive facebook use perceived effect passive facebook use mood also assessed participants responded vignettes describing daily life events well responding question passive facebook use mood completing bergen facebook addiction scale results suggested individuals use facebook escape association escapism passive facebook use passive facebook addiction social contact positive effect passive facebook use participants perceived passive facebook use effect mood findings suggest passive facebook use less effective method escape general facebook use reducing individuals likelihood experiencing facebook addiction symptoms elsevier ltd rights reserved
vector raster two types spatial data structures used geographic information system gis development gis remote sensing technologies rapidly convert raster vector data establish topological relations among vectorized polygons becoming bottleneck data integration gis based previous work improved vectorization method proposed vectorize classified raster data quickly automatically establish topological relations accordance connection information arcs nodes sides polygonal attributes arcs next arc searched directly attribute matching constructing polygons thereby improving search efficiency moreover method addressed problems self intersecting polygons shared boundary multi nested islands gave corresponding solutions establish topological relations entire image quickly two experiments one comparison vectorization two different classified raster maps comparison several methods carried test accuracy efficiency method results show method solves self intersecting polygons shared boundary multi nested islands problems addition vectorization speed double commercial software arcgis advantage method becomes obvious number polygons increases thus method vectorize large complex classified raster data sufficient efficiency practical use establish topological relations among vectorized polygons
background seasonal variations mood behavior common among general population may deteriorating effect cognitive functions aims study effect seasonal affective disorder sad like symptoms cognitive test performance evaluated detail methods data derived study mental health early adulthood finland participants filled modified seasonal pattern assessment questionnaire spaq performed cognitive tests verbal visual skills attention general intelligence results sad like symptoms especially regarding seasonal variations weight appetite significant effect working memory digit span backward auditory attention short term memory digit span forward seasonal variations sleep duration mood effect auditory attention short term memory digit span forward respectively seasonal variations social activity energy level effect conclusions seasonal changes mood appetite weight impairing effect auditory attention processing speed performance tests repeated different seasons attention needs given appropriate season test
many conventional computer vision object tracking methods sensitive partial occlusion background clutter partial occlusion little background information may exist bounding box tends cause drift end paper propose robust tracker based key patch sparse representation kpsr reduce disturbance partial occlusion unavoidable background information specifically kpsr first uses patch sparse representations get patch score patch second kpsr proposes selection criterion key patch judge patches within bounding box select key patch according location occlusion case third kpsr designs corresponding contribution factor sampled patches emphasize contribution selected key patches comparing kpsr eight contemporary tracking methods benchmark video data sets experimental results show kpsr tracker outperforms classical state art tracking methods presence partial occlusion background clutter illumination change
deficient emotional experience recognized one central features psychopathy impressive body empirical findings regarding emotion processing psychopathy amassed past several decades resulting two broad theoretical perspectives general emotional deficit perspective postulates globally reduced capacity emotional experience processing across emotional spectrum contrast according specific emotional deficit perspective psychopathy associated abnormal experience specific types emotion several distinct hypotheses proposed latter perspective systematically critically review findings peer reviewed research emotion processing psychopathy relation two theoretical perspectives general findings suggest compared controls psychopaths exhibit behavioral psychophysiologic regional brain activation anomalies processing emotion ratings self arousal stimulus valence intensity differ controls however behavioral findings examined separately emotion type overall pattern findings clearly consistent dominant theoretical perspectives emotion processing psychopathy summarize current state field including consistencies inconsistencies literature offer alternative explanations findings outline directions future research elsevier ltd rights reserved
consider two dimensional range maximum query rmq problem given array containing elements ordered set encode array position maximum element specified range rows range columns found efficiently focus determining effective entropy rmq many bits needed encode array rmq queries answered without accessing array give tight upper lower bounds expected effective entropy case contains independent identically distributed random values give new upper lower bounds case array contains rows latter results improve upon upper lower bounds brodal also give efficient data structures rmq whose space usage close effective entropy elsevier rights reserved
paper solves data driven simultaneous fault detection control sfdc problem multi variable laboratory process named quadruple tank process adjustable zero located left right half plaue knowledge mathematical model process needed input output time domain data used solving data based infinity optimization problem solving problem yields data driven infinity controller detector unit modest complexity able achieve control fault detection objectives tradeoff objectives established tuning scalar parameter weighting matrices effectiveness proposed methodology demonstrated minimum phase non minimum phase plants presence incipient abrupt faults
schlieren effect evaluated employing homemade led based photometer furnished flow cell long optical pathlengths exploited tool develop automated photometric procedure reagentless ethanol determination distilled ethanolic beverages analytical procedure employed multicommuted flow analysis manifold using solenoid mini pumps fluid propulsion aiming evaluate schlieren effect would affected length flow cell photometer designed coupled flow cells optical pathlengths ranging control flow system data acquisition performed using arduino due microcontroller coupled microcomputer serial interface programmed work slave optimal operational conditions sampling loop length flow cell optical pathlength led emission wavelength magnitude signal generated schlieren effect linearly related ethanol concentration aqueous medium efficacy procedure ascertained performing ethanol determination distilled ethanolic beverages yielding results agreement achieved using aoac official method confidence level useful features include sampling rate determinations per hour detection limit ethanol standard deviation typical sample containing ethanol elsevier rights reserved
background infant skin susceptible dryness irritation external factors including topical skin care products formulated infant skin may increase risk contact dermatitis parents frequently express concern regarding potential harm ingredients skin care products seek information complicated several skin care myths purpose purpose literature review provide evidence based information educate parents use products preterm term infants search strategy multiple searches using pubmed conducted including search terms infant skin care infant products infant bath emollients diaper skin care diaper wipes reference lists comprehensive reviews also scanned google searches used assess consumer information product information regulatory guidelines findings little scientific evidence support safety natural organic products infant skin raw materials originate different sources complicating testing comparisons ingredients research shows cleansers formulated infant skin weaken skin barrier way harsher soaps detergents oils lowest oleic acid content provide lower risk irritant contact dermatitis implications practice nurses must informed natural organic products preservatives fragrances know definition commonly used marketing terms implications research decisions regarding use infant products preterm term infants evidence based research needed support claims regarding safety products used infant skin
purpose providing long acting reversible contraception larc immediate postpartum period evidence based strategy expanding women access highly effective contraception reducing unintended rapid repeat pregnancy purpose article demonstrate application implementation science methodology study complexities rolling policies promote immediate postpartum larc use across states description immediate postpartum larc learning community sponsored association state territorial health officials astho made multi disciplinary multi agency teams early adopting states medicaid reimbursement policies promoting immediate postpartum larc partners include federal agencies maternal child health organizations learning community discussed barriers opportunities strategies promising practices person meeting implementation science theory methods including consolidated framework implementation research cfir recent compilation implementation strategies provide useful tools studying complexities implementing immediate postpartum larc policies birthing facilities across early adopting states assessment demonstrate utility framework guiding expansion immediate postpartum larc policies illustrative examples barriers strategies discussed person astho learning community meeting organized five cfir domains intervention characteristics outer setting inner setting characteristics individuals involved process conclusion states considering adopting policies learn astho immediate postpartum larc learning community applying implementation science principles may lead effective statewide scale immediate postpartum larc evidence based strategies improve women children health
lung allocation score las system older sicker patients prioritized lung transplantation impact changes health related quality life hrql transplant determined single center prospective cohort study assessed hrql repeatedly years using physical mental health respiratory specific airway questionnaire revised euroqol visual analog scale utility measures multivariate linear mixed models jointly modeled death also tested changes valued life activities disability bmi allograft function min walk test exercise capacity predictors hrql change among initial participants eligible improved hrql measures mental health improved threefold greater minimally clinically important difference compared younger participants aged improved less physical mental health improvements disability accounted much hrql improvement las era affords meaningful durable hrql improvements mediated amelioration disability identifying factors limiting hrql improvement selected subgroups especially aged needed maximize net benefits prospective longitudinal adult cohort authors find lung transplantation substantially improves health related quality life improvement largely mediated amelioration physical disability though older adults undergoing transplantation diagnoses cystic fibrosis derive smaller benefit health related quality life
introduction last years view subclinical endocrine disorders represent milder forms clinically overt disease emerged accordingly proposed compensated hypogonadism represents genuine clinical subset late onset hypogonadism aim aim present study investigate associations compensated hypogonadism particular clinical psychological characteristics male subjects complaining sexual dysfunction methods excluding documented genetic causes hypogonadism unselected consecutive series patients consulting unit sexual dysfunction studied compensated hypogonadism identified according european male ageing study criteria total testosterone nmol luteinizing hormone main outcome measures several hormonal biochemical instrumental penile doppler ultrasound parameters studied along results structured interview erectile dysfunction siedy androtest results one hundred seventy subjects compensated hypogonadism whereas overt hypogonadism adjustment confounding factors specific sexual symptoms associated compensated hypogonadism however compensated hypogonadism individuals often reported psychiatric symptoms detected middlesex hospital questionnaire score compared eugonadal overt hypogonadal subjects adjusted odds ratios respectively addition subjects compensated overt hypogonadism increased predicted risk cardiovascular events assessed progetto cuore risk algorithm compared eugonadal individuals accordingly mortality related major adverse cardiovascular events maces mace incidence significantly higher subjects compensated overt hypogonadism compared eugonadal subjects conclusions present data support concept compensated subclinical hypogonadism represents new clinical entity possibility subclinical hypogonadism could normal response hypothalamus pituitary testis axis somatic illness considered studies urgently needed clarify latter point
deal information incompleteness error supervising difficulties caused hardships information synergy sharing among current medical institutions article proposes solution construct city smart heathcare data system design synchronizing medical institution heterogeneous database data center aforementioned problems solved analyzing needs city medical data center article takes nosql database hadoop basis system construction meanwhile comparative analysis several existing nosql databases habase found suitable storing processing massive data article proposes new database modeling thought object relationship modeling reference relational database modeling modeling thought compensates non relational databases deficiencies front relational databases utilizing new modeling thought solution synchronize heterogeneous databases identically data center article completes construction city smart heathcare data system
cultural power public symbol shift time public retrievability iconic red pink ribbons followed different paths red ribbons rose rapidly fell favor quickly whereas presence pink ribbon grew steadily time explains different trajectories identify explain differences analysis archival newspaper data use secondary sources create case studies important moments histories symbols paper makes three interventions elaborates extends schudson discussion cultural power refining mechanism retrievability adding recognizability demonstrates importance organizations maintaining high retrievability recognizability face criticism controversy along politicians celebrities corporations introduces genre violation mechanism undermining symbol cultural power elsevier rights reserved
alkylferrocene based burning rate catalysts exhibit high migration tendency volatility prolonged storage fabrication process solid propellants retard migration problems eight ionic compounds composed ferrocenylmethyldimethylammonium cation paired common energetic anion synthesized one step procedure compounds characterized ftir nmr vis spectroscopy well elementary analysis crystal structures confirmed single crystal ray diffraction dsc analyses indicated exhibit high thermal stability cyclic voltammetry studies suggested show reversible quasi reversible redox waves anti migration results revealed low migratory compounds exhibits high migration trends curves degrees showed low volatility high low impact sensitivity depending anions compounds exhibit significant effect thermal decomposition ammonium perchlorate accelerate thermal degradation trinitro triazacyclohexane rdx among best one unexpectedly compound tetrazolate anion decompose original reactants temperature higher melting point could show smart material functionality solid propellants
accuracy imaging bulk volume estimation apple slices process drying temperatures degrees investigated compared physical caliper measurements initial hypothesis estimate bulk volume cylindrically shaped apple slices diameter thickness imaging imaging diameter showed strong agreement caliper measurements throughout entire drying process however imaging thickness accurate due irregular shrinkage bending phenomena linear model reflecting relationship diameter bulk volume developed validated temperatures degrees showed good correlation imaging diameter bulk volume changes range moisture contents relative percentage error prediction model approximately suggests imaging used robust tool bulk volume estimation apple slices convective drying
service providers often used mantra service smile strategy engender customer satisfaction findings current research indicate smile alone may sufficient achieving service excellence specifically work extends prior research suggesting customers positive reactions duchenne authentic smiles compared non duchenne non genuine smiles two experimental vignette studies examined influence type smile service provider displays duchenne non duchenne gender service provider perceptions service quality well stereotype content model dimensions competence warmth results suggest type smile duchenne non duchenne impacts evaluations service providers terms perceived level competence well perceived service quality ratings implications hiring training service providers also discussed elsevier ltd rights reserved
objectives study assesses ability maintain contact participants enrolled emergency contraception trial months follow based modes contact provided enrollment study design data came clinical trial offering women copper intrauterine device oral levonorgestrel modified poisson regression used assess predictors associated ability contact study participants months enrollment results data available participants could contacted months contact months greatest whose preferred method contact text messaging mail contacted worst landline phone contacted controlling age mail address text messaging language preference type chosen insurance preferred contact phone increased likelihood follow risk ratio confidence interval landline reduced woman likelihood contacted months compared women contract cell conclusion women landline contact poor follow year women preferred mail text highest rate follow elsevier inc rights reserved
hepatitis virus hcv infection one leading causes hepatocellular carcinoma hcc worldwide mechanistic basis chronic hcv infection furthers hcc process remains poorly understood accumulating evidence indicates hcv core nonstructural proteins provoke activation wnt beta catenin signaling pathway evidence supporting role wnt beta catenin signaling onset progression hcc compelling convincing molecular explanations expression viral effectors translates increased activity wnt beta catenin signaling machinery still largely lacking hampering design rational strategies aimed preventing hcc furthermore increased signaling especially associated hcc oncogenesis context hcv infection remains obscure well review body contemporary biomedical knowledge role wnt beta catenin pathway progression chronic hepatitis cirrhosis hcc explore potential hypotheses mechanisms involved
objective determine effects prebiotics synbiotics adults functional constipation medline embase cochrane library searched literature published february selected randomized controlled trials rcts reported administration prebiotics synbiotics adults end points included stool frequency stool consistency symptoms related constipation mean differences standard mean differences smd used continuous outcomes risk ratios discontinuous outcomes using random effects model cochrane risk bias tool used determine quality trials funnel plots egger test used analyze publication bias included rcts involving patients administered prebiotics rcts involving patients administered synbiotics prebiotics increased weekly stool frequency bowel movements week improved stool consistency smd subgroup analysis showed specific effects galacto oligosaccharides stool frequency consistency ease defecation abdominal pain synbiotics significantly improved stool frequency bowel movements week consistency smd reduced whole gut transit time patients subgroup analysis showed specific effects fructo oligosaccharides probiotic combinations stool frequency consistency straining defecation bloating galacto oligosaccharides synbiotics made fructo oligosaccharides probiotic combinations may improve stool frequency consistency symptoms related constipation
paper first follow ateniese work provides upper bounds pixel expansion visual cryptography schemes vcss kinds graph access structures require subset parties determine secret contain edge graph constructive upper bounds derived graph decomposition technique generalize ateniese method comparing optimal pixel expansion vcss two different access structures
hallucinations constitute one symptom domains psychotic disorders dsm suggesting diagnostic significance group disorders although specific featural properties hallucinations negative voices talking third person location external space longer highlighted dsm likely residual assumption hallucinations schizophrenia identified based candidate features investigated whether certain featural properties hallucinations specifically indicative schizophrenia conducting systematic review studies showing direct comparisons featural clinical characteristics auditory visual hallucinations among population groups one included schizophrenia total articles reviewed included hallucinations major groups nonclinical groups drug alcohol related conditions medical neurological conditions psychiatric disorders results showed single hallucination feature characteristic uniquely indicated diagnosis schizophrenia sole exception age onset late adolescence among features hallucinations schizophrenia considered shared psychiatric disorders medical neurological conditions drugs alcohol conditions nonclinical groups additional differences rendered nonclinical groups somewhat distinctive clinical disorders overall considering hallucinations inadvisable give weight presence featural properties alone making schizophrenia diagnosis important focus instead occurrence symptoms value hallucinations indicator vulnerability
effective team communication prerequisite software quality project success implies correctly elicited customer requirements conduction occurring change requests adhere releases team communication complex construct consists numerous characteristics individual styles influencing factors dynamic intensities project elements complicated measured scheduled especially newly formed teams according software developers experiences teams would highly desirable recognize dysfunctional underestimated communication behaviors already early project phases otherwise negative affects may cause delay releases even endanger software quality introduce approach feasibility forecasting team communication behavior student software projects build first forecasting model involves software engineering industrial psychological terms extract multi week communication forecasts accurate results model consists nearest neighbor machine learning algorithm trained evaluated student software projects previously taken field study study encouraging first step towards forecasting team communication reveal potential miscommunications project aim give young software developing teams experience based assistance information flow enable adjustment dysfunctional communication avoid fire fighting situation even risks alternating software qualities
basis zero voltage switching zvs operation class resonant converter provides excellent conversion efficiency even though works high frequency unfortunately zvs operation sensitive circuit situations circuit components shifting zvs working drift around dominant point may fail work zvs study active zvs tracking control method proposed cope circuit components shifting basis exact analysis zvs operation conditions first searching procedure proposed decide optimal switching frequency next current phase feedback active zvs tracking controller built retain circuit works optimum zvs operation adaptively tuning switching frequency counteract components shifting addition theoretical analysis computer simulation proposed tracking controller applied implement mhz class inverter field programmable gate array fpga based controller
study present neural network based approach represent nonlinear takagi sugeno system linear differential inclusion ldi state space representation utilized deal models taking advantage ldi representation stability conditions controller design derived class nonlinear systems controller design based fuzzy control parallel distributed compensation scheme utilized construct global fuzzy logic controller blending local state feedback controllers furthermore control problem reduced linear matrix inequality problems schur complements efficient interior point algorithms available matlab toolbox solve problem chaotic system simulated show feasibility proposed fuzzy controller design approach
work analyse movements muscular activity motocross sessions neck brace influence movements measured terms angles using two biometrics angular sensors one planar flexion one torsion muscle activity registered using four pairs electrodes muscle selected sterno cleido mastoid left right trapezium left right results obtained conclude pilot wants focus attention next jump obstacle accelerations different nature acting neck therefore isometric contractions predominant fact brace reduce rotational range motion positive result pilot field view modified safety requirement according evidence fatigue effect brace useful protect pilot accidents also supporting device driving sessions authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
bone remodeling elegantly orchestrated process osteocytes osteoblasts osteoclasts function syncytium maintain modify bone microscopic level bone consists cells create destroy monitor bone matrix cells interact coordinated manner maintain tightly regulated homeostasis regulation responsible observed increase bone gain dominant arm tennis player observed increase bone loss associated spaceflight osteoporosis manner cells interact bring change bone quality quantity yet fully elucidated efforts understand multicellular complexity ultimately lead eradication metabolic bone diseases osteoporosis improved implant longevity experimentally validated mathematical models simulate functional activity offer eventual predictive capabilities offer tremendous potential understanding multicellular bone remodeling undertake initial challenge develop mathematical model bone formation validated vitro data obtained osteoblastic bone cells induced mineralize quantified days culture cellular automata model constructed simulate vitro characterization permutation tests performed compare distribution mineralization cultures distribution mineralization mathematical models results permutation test show distribution mineralization characterization mathematical model come probability distribution therefore validating cellular automata model elsevier inc rights reserved
research suggesting nonsuicidal self injury nssi may belong distinct diagnostic category led inclusion nssi disorder dsm section future study limited research however examining validity criterion frequency criterion current study aimed examine validity frequency criterion nssi disorder use exploratory data mining method structural equation modeling trees way determine nssi frequency optimally discriminates pathological nssi normative behavior among undergraduate students engaged nssi previous year model included psychopathology symptomology found comorbid nssi cognitive affective deficits commonly associated nssi results demonstrated first split individuals act nssi past year expected among individuals previous acts optimal split nssi acts past year results current study suggest individuals acts nssi past year compared acts less may represent severe group self injurers individuals reported higher levels related psychopathology symptomology cognitive affective deficits addition decreased quality life findings potential implications proposed frequency criteria nssi disorder pathological nssi characterized
eyes shown play key role human social interactions however date comprehensive cross discipline model provided framework account uniquely human responses eye cues review present framework brings together work phylogenetic ontogenetic neural bases perceiving responding eyes specifically argue two process model first process ensures privileged attention information encoded eyes important detection minds second process permits decoding information contained eyes concerning another person emotional mental states degree processes unique humans emerge different times infant development mapped onto distinct interconnected brain regions likely serve critical functions facilitating cooperative interactions humans also present evidence show oxytocin key modulator sensitive responding eye cues viewing eyes windows minds therefore considered hallmark feature human social functioning deeply rooted biology
composite resin blocks computer aided design computer aided manufacturing cad cam applications recently become available however cad cam composite resins lower wear resistance accumulate plaque cad cam ceramic materials assessed effects sio nanocomposite film coating four types cad cam composite resin blocks cerasmart katana avencia block lava ultimate block surface hardness bacterial attachment composite blocks coating demonstrated significantly greater vickers hardness reduced surface roughness greater hydrophobicity without coating adhesion streptococcus mutans coated specimens significantly less uncoated specimens reduced levels bacterial adherence coated surface still evident treatment saliva surface modification sio nanocomposite film coating potential improve wear resistance susceptibility plaque accumulation cad cam composite resin restorations
personalized learning environment desirable computer programming education important issue personalized learning environment know learning status student article proposes method skp based student learning status description skp based slsd help instructors know student individual learning status programming skp based slsd focus syntactic knowledge called syntax knowledge point skp extracted program source code firstly gathers syntactic knowledge learned students extracting skp source code teaching materials exercises model answers student collects learning activities skp extracting skp source code student read taught lectures wrote exercises tests finally student understanding skp estimated based collected data student learning status described understanding skps skp based slsd information used describe student learning status detail better defined better handled computer systems also conducted experiments proved skp based slsd effective feasible
berta uncertainty principle presence quantum memory berta nat phys reveals uncertainties quantum side information observables recent important work coles piani phys rev entropic sum controlled first second maximum overlaps two projective measurements generalize entropic uncertainty relation presence quantum memory find exact dependence largest overlaps two measurements dimensional hilbert space bound rigorously shown strictly tighter previous entropic bounds presence quantum memory potential applications quantum cryptography entanglement witnesses quantum key distributions
long acting nonsteroidal anti inflammatory drug formulations intra articular injection might effective management joint pain inflammation associated sports injuries osteoarthritis study prodrug based delivery system evaluated synthesized diclofenac ester prodrug weak base pka relatively high solubility low much lower solubility physiological degrees biological media including human synovial fluid prodrug cleaved diclofenac mediated esterases situ precipitation prodrug observed upon addition concentrated slightly acidic prodrug solution phosphate buffer degree supersaturation accompanying precipitation process pronounced phosphate buffer rotating dialysis cell model slightly acidic prodrug solution added donor cell containing resulting continuous appearance diclofenac acceptor phase initial lag period detectable amounts prodrug found rat joint days knee injection acidic prodrug solution wiley periodicals inc american pharmacists association pharm sci
paper domain application well known modern applied mathematical methods control structure oil industry electrical submersible pumps esp telemetry system allows obtaining information neighborhood different heavy electromagnetic noises telemetry system needs receive accurate information pump unit intake pressure temperature importantly submersible electric motor stator cooling oil insulation resistance successful exploitation esp increasing disturbance levels corrupted analog telemetry signal resulting increasing noise levels however often still audible control still reliable though beyond certain disturbance level called digital cliff digital telemetry signal control may stop abruptly fig paper analog signal processing implementation researched detection efficient adaptive noise cancelling filters among dozens recognized ones oil industry esp telemetry systems severely noisy conditions ten applied adaptive filter algorithms three shown successfully good results early prediction esp electric motor real insulation disruption
present study morphometric geophysical analysis three major rainwater harvesting basins baha province saudi arabia carried using geographical information system gis techniques geophysical analysis gis techniques aimed create spatial database three basins used determine morphometric parameters stream attributes morphometric analysis revealed maximum elevation basins upper stream sea level aqiq medhas mathalmat basin respectively maximum elevation decreases steep slopes three basins toward dams site general flow direction streams aqiq basin goes southwest northeast following main direction arabian shield structure medhas basin flow goes south north wide flat areas downstream portion basin near dam site southeast west mathalamt basin morphometric parameters aqiq basin imply basin largest area perimeter total stream length medhas basin comes second largest area perimeter total stream length mathalamt basin area perimeter total stream length three basins medium drainage density value aqiq medhas mathalamat basins relief ratio aqiq basin medhas basin mathalamt basin noticed ratios indicate high permeable landscape aqiq mathalamt basins medium permeable landscape medhas basin aqiq mathalamt basins similar elongation circularity respectively indicates two basins fairly elongated shape elongation circularity estimated medhas basin respectively drainage pattern aqiq medhas basins high dendritic shape mathalamt basin simple dendritic shape geophysical survey performed using vertical electrical sounding ves resistivity geophysical analysis reflected presence several different layers resistance high resistance broken vertical bar depth due dry river sediments dams location areas presence basement rocks climatic change results confirm output geological study give indication state recharge rainwater harvesting three basins
qualcomm mems technologies developing commercializing revolutionary mems based technology low power refractive displays concurrent product development manufacturing engineering tft foundary taiwan significant research activities state art mems research innovation center san jose california enable future technology generations paper overview imod fundamentals current status technology well discuss research projects areas advanced materials processes concepts future mems displays manufacturing
candida albicans common yeast resides human body occasionally cause systemic fungal infection namely candidiasis infection rate gradually increasing becoming major problem public health accordingly first time investigated antifungal activity mode action silibinin natural product extracted silybum marianum milk thistle albicans treatment silibinin generation reactive oxygen species ros mitochondria cause yeast apoptosis via oxidative stress increased compared untreated cells subsequently found disturbances ion homeostasis release intracellular accumulation cytoplasmic mitochondrial among phenomena mitochondrial overload particularly plays crucial role process apoptosis promoting activation pro apoptotic factors therefore investigated significance mitochondrial apoptosis employing ruthenium red additional apoptosis hallmarks mitochondrial membrane depolarization cytochrome release caspase activation phosphatidylserine exposure dna damage observed response silibinin treatment whereas pre treatment seemed block responses summary results suggest silibinin induces yeast apoptosis mediated mitochondrial signaling albicans elsevier ltd rights reserved
objective better understanding effects chronically delivering compounds substantia nigra nearby areas important development new therapeutic approaches treat alpha synucleinopathies like parkinson disease whether chronic intranigral delivery infusate could achieved without causing motor dysfunction marked pathology remains unclear authors evaluated tolerability continuously delivering infusate directly rhesus monkey substantia nigra via programmable pump coupled novel intraparenchymal needle tip catheter surgically implanted using mri guided techniques methods mri contrast agent gadopentetate dimeglumine magnevist used noninvasively evaluate catheter patency infusion volume associated flow rates sequentially tested animals min days right substantia nigra min days plus min additional days left substantia nigra flow rate tolerability assessed via clinical observations microscopic examination striatum midbrain regions results evaluation postsurgical mri indicated catheters remained patent throughout study volume distribution achieved left midbrain region rate min greater achieved right midbrain region constant rate min nearly fold flow rates provided sufficient infusate coverage rhesus possibly human midbrain region indications observable deficits behavior histopathological evaluations confirmed catheter tips placed near pars compacta region substantia nigra animals evidence infection catheter sites mild moderate microglial reactions observed catheter track sites comparable infusion rates finally neither observable decrease tyrosine hydroxylase staining striatum detectable necrosis neurons pars compacta region substantia nigra animals conclusions data study support feasibility using pump catheter system chronic intranigral infusion lay foundation using approach treat parkinson disease related degenerative diseases would benefit targeted drug delivery substantia nigra brainstem regions
study investigated association child maltreatment body mass index bmi using data four waves wave korean children youth panelsurvey collected south korean national youth policy institute employed latent growth curve modeling approach estimate unobserved latent trajectory test longitudinal effects child abuse neglect bmi results indicate child abuse significantly associated bmi children report higher levels abuse tend higher rates increase bmi study addresses gap literature demonstrating parent maltreatment child long term effect rate change bmi time
popularity mobile devices steadily growing recent years devices heavily depend software underlying operating systems applications run prior research showed mobile software different traditional large software systems however date research conducted traditional software systems little work focused issues mobile developers face therefore paper use data popular online site stack overflow analyze posts examine mobile developers ask employ latent dirichlet allocation based topic models help summarize mobile related questions findings show developers asking app distribution mobile apis data management sensors context mobile tools user interface development also determine popular mobile related issues difficult explore platform specific issues investigate types questions mobile developers ask findings help highlight challenges facing mobile developers require attention software engineering research development communities future establish novel approach analyzing questions asked forums
heat storage equipment plays important role micro cogeneration plants unconsumed heat released needed pcm heat exchangers alternative commonly used storage tanks moreover pcm heat exchangers occupy less space amount stored energy paper examines energy performance heating power micro cogeneration system applied office space hot water thermal energy storage system two latent heat thermal energy storage systems based pcm plate heat exchangers compared performances analyzed dynamic conditions operating strategies pcm heat exchanger water tank discussed terms heat demand power supplied internal combustion engine micro chp system thermal performance two possible pcms paraffin palmitic acid form plates inside heat exchanger analyzed processes charging pcm melting discharging pcm solidification charge discharge duration well capability deliver appropriate heat transfer rate compared palmitic acid provides better results higher heat transfer rates accumulated energy less storage units needed meet heating demand elsevier rights reserved
background unhelpful sleep related cognitions play important role insomnia major depressive disorder role seasonal affective disorder yet explored therefore purpose study determine individuals seasonal affective disorder sad sleep related cognitions similar primary insomnia insomnia related comorbid nonseasonal depression methods participants completed dysfunctional beliefs attitudes sleep item scale dbas structured interview guide hamilton depression rating scale seasonal affective disorder version sigh sad assesses self reported sleep problems including early middle late insomnia hypersomnia previous week participants assessed winter episode depressive disorder results individuals sad likely report hypersomnia sigh sad well combined presentation hypersomnia insomnia pittsburgh sleep quality index psqi sad group reported dbas scores range associated clinical sleep disturbance dbas scores strongly associated reports early insomnia suggesting circadian misalignment limitations limitations include self report nature sigh sad instrument insomnia hypersomnia reports based conclusions future work could employ sleep chronobiological focused interventions improve clinical response sad elsevier rights reserved
paper describe findings three year evaluation well developed mathematics professional development program commercially available wide scale professional development designed improve teachers mathematical knowledge teaching enable elicit student thinking reasoning mathematics lessons specifically focused helping teachers learn mathematics understand children learn math use formative assessment develop insight specific students know know develop effective classroom instructional strategies enable student problem solving participants included fourth fifth grade teachers teaching low income schools within single district teachers randomly assigned within schools either business usual control group receive professional development training consisted week long summer institute four six service days school year training run full time trained associates find limited evidence positive impacts teachers mathematical knowledge teaching effects instructional practice student outcomes
interpretation endpoints overall response rate clinical trials depends accurate reliable measurement identification tumors regulatory agencies recommend blinded reviews imaging data independent review committees ircs differences response outcomes arise ircs site investigators raise regulatory sponsor concerns evaluate discrepant tumor response assessments irc unblinded investigators complete versus partial response respectively occurring irc assessed responders enrolled patients treatment naive non hodgkin lymphoma randomized study irc investigators likely correct cases respectively investigators likely make errors misinterpreting lymph node data utilizing pet results post hoc finding suggests possible role post training site evaluation audit retraining needed specialized consensus committee concurrent blinded review site central data
background mothers motion mim randomized controlled trial aimed help young low income overweight obese mothers prevent weight gain promoting stress management healthy eating physical activity paper describes mim recruitment challenges reports demographic characteristics affecting enrollment methods participants african american non hispanic white recruited special supplemental nutrition program women infants children wic michigan faced numerous recruitment challenges learned several strategies facilitated recruitment logistic regression analyses performed examine demographic characteristics affect enrollment results women higher body mass index bmi late postpartum breastfeeding early postpartum breastfeeding likely enroll counterparts compared african american women non hispanic white women likely enroll also women non smokers higher education likely enroll smoked lower education conclusion future lifestyle behavioral intervention studies similar target audiences may consider tailoring recruitment messages based relevant participant demographic characteristics identified potential determinants enrollment study authors published elsevier inc
hypothyroidism hyperthyroidism associated glucose intolerance calling question contribution thyroid hormones glucose regulation analogues derivatives may effective treatment options glucose intolerance insulin resistance potential glucoregulatory effects conditions impaired metabolism well described assess effects thyroxine glucose intolerance model insulin resistance oral glucose tolerance test ogtt performed three groups rats lean long evans tokushima otsuka leto obese otsuka long evans tokushima fatty oletf oletf day weeks attenuated glucose intolerance decreased index iri treated oletf compared untreated oletf despite decrease muscle glut mrna expression increased mrna expressions muscle monocarboxylate transporter mct deiodinase type sirtuin sirt uncoupling protein ucp fold respectively compared oletf activation amp activated protein kinase ampk insulin receptor significantly altered suggesting improvements glucose intolerance independent enhanced insulin mediated signaling results suggest treatment increased influx skeletal muscle increase increased availability biologically active upregulate key factors sirt ucp involved cellular metabolism glucose homeostasis
background migraine recurrent headache disease related genetic variants brain derived neurotrophic factor bdnf gene valmet polymorphism found associated migraine however roles disorder well established conduct meta analysis address issue methods pubmed web science cochrane databases systematically searched identify relevant studies odds ratio corresponding confidence interval used estimate strength association bdnf gene polymorphism migraine results four studies cases controls fulfilling inclusion criteria included meta analysis overall data showed significant association polymorphism migraine allele model recessive model additive model respectively also found significant association polymorphism migraine allele model recessive model additive model respectively conclusion meta analysis suggested bdnf polymorphism associated common migraine caucasian population studies awaited update finding asian population types migraine
energy efficiency internal combustion engine reached recently increase efficiency homogeneous charge compression ignition hcci proposed however available commercial engine yet main problem lies delayed heating rate spite fast reaction homogeneous charged state hcci excess air overcome difficulty modification fuel vaporization liquid gasoline water electrolysis gas air adopted order warrant fast high temperature rise experiments carried single cylinder engines supplied four different manufacturers experimental results show fuel consumption decreased compared case supplying liquid fuel believed due combined effects high fast heating potential water electrolysis gas together efficient turbulence mixing effect vaporized fuel excess air method drawbacks caused lean burn hcci engine small power range overcome elsevier ltd rights reserved
background consumption sugar sweetened beverages ssb may contribute development overweight among children present study aimed evaluate associations family home related factors children ssb consumption explored associations within ethnic background child methods cross sectional data population based water campaign study used parents primary school children years completed questionnaire socio demographic characteristics family home related factors child ssb intake family home related factors study cognitive variables parental attitude subjective norm environmental variables availability ssb parenting practices habitual variables habit strength taste preference regression analyses used evaluate associations family home related factors child ssb intake results mean age children years girls child average ssb intake litres per day child age parents subjective norm parenting practices parental modelling positively associated child ssb intake availability ssb home school parental attitude negatively associated child ssb intake associations study differed according child ethnic background explained variance full models ranging children moroccan turkish ethnic background children dutch ethnic background conclusions results provide support interventions targeting children ssb intake focussing identified family home related factors active participation parents also relationships factors child ssb intake differed children distinct ethnic backgrounds therefore would recommend tailor interventions taking account ethnic background family
background ankylosing spondylitis common inflammatory rheumatic disease affects axial skeleton lead structural functional impairments negative impact person daily life activities early diagnosis exercise patient education factors playing major role prognosis objective purpose study compare structured theoretical exercise educational program routine clinic educational efforts parameters disorder month follow materials methods randomized educational intervention study performed patients day structured education exercise program applied first group patients group subgroups consisting patients patients group exercises throughout education program second group followed routine clinical care effectiveness treatment assessed bath ankylosing spondylitis functional basfi bath ankylosing spondylitis disease activity basdai bath ankylosing spondylitis global bas bath ankylosing spondylitis metrology indices basmi chest expansion short form ankylosing spondylitis quality life scale asqol laboratory parameters patients patients evaluated initiation months results significant improvements basfi basdai bas chest expansion asqol indices observed group difference could found basmi chest expansion conclusion structured educational exercise intervention positive effect functional status disease activity general well quality life also shows education programs within routine treatment program
simulation blood flow stenosed artery using smoothed particle hydrodynamics sph new research field particle based method different traditional continuum modelling technique computational fluid dynamics cfd techniques harness parallel computing process hemodynamics cardiovascular structures objective study develop test new robust method comparison arterial flow velocity contours sph well established cfd technique implementation sph computed tomography reconstructed arteries new method developed based three dimensional straight curved arterial models millimeter range stenosis middle section study employed particles study number particles influences sph versus cfd deviation blood flow velocity distribution increasing particle density diminishing effect deviation determined critical particle density particles based reynolds number inlet arterial flow simulation using critical value particle density avoid unnecessarily big computational expenses effect simulation accuracy particularly shown sph method big potential used virtual surgery system simulate interaction blood flow reconstructed vessels especially stenosis plaque encountering vasculopathy employing simulation results output clinical surgical procedures
background pregnancy patients rheumatoid arthritis axial spondyloarthritis axspa experience active disease might influenced adjustment treatment around conception aim study identify possible risk factors disease flares pregnancy evaluate effect treatment pregnant patients experiencing flare methods pregnant patients axspa prospectively followed pregnancy disease activity flares disease activity analyzed regard medication results among pregnant patients disease flares pregnancy occurred patients patients axspa diseases active disease tumor necrosis factor inhibitor tnfi discontinuation early pregnancy identified risk factors disease flares pregnancy patients patients tnfi discontinued treatment time positive pregnancy test stopping tnfi disease activity increased reflected peaking reactive protein levels first trimester relative risk flare patients stopping tnfi initiation tnfi glucocorticosteroid treatment patients resulted disease improvement second third trimesters comparison patients without tnfi preconception period used pregnancy compatible antirheumatic drugs showed mild stable disease activity pregnancy patients axspa patients tnfi discontinued treatment time positive pregnancy test patients axspa stopping tnfi disease aggravation second trimester could observed relative risk flare group spite initiated tnfi treatment patients disease activity remained elevated throughout pregnancy patients axspa without tnfi preconception period showed persistent high disease activity prepregnancy postpartum period conclusions basis risk benefit analysis stabilize disease activity prevent flare pregnancy patients axspa tailored medication including tnf inhibitors considered beyond conception
radix fast fourier transform fft algorithm used achieve time radix butterfly reduced number twiddle factor multiplication paper present new identical radix fft algorithms number butterfly twiddle factor multiplication difference twiddle factor stage location signal flow graph sfg analyze algorithms shown round noise identical radix radix radix fft algorithms output reduced respectively
background excels postmarketing observational cohort study commitment food drug administration assess long term safety omalizumab observational setting focusing predominantly malignancies objective aim study examine potential association omalizumab cardiovascular cerebrovascular cbv events excels methods patients years age moderate severe allergic asthma treated omalizumab baseline followed years analyses included overall cbv events focused subset arterial thromboembolic events ates comprising death myocardial infarction ischemic stroke transient ischemic attack unstable angina prespecified analysis end point ate conducted control available potential confounders blinded independent expert panel adjudicated events results baseline cohorts similar demographic characteristics severe asthma common omalizumab versus non omalizumab group omalizumab treated patients higher rate cbv serious adverse events per person years pys non omalizumab treated patients per pys ate rates per pys patients pys omalizumab cohort patients pys non omalizumab cohort control available confounding factors hazard ratio conclusion observational study demonstrated higher incidence rate cbv events omalizumab versus non omalizumab cohort differences asthma severity cohorts likely contributed imbalance increase risk excluded
paper presents data acquisition system available components study feasibility different existing methodologies linked field data acquisition remote photovoltaic water pumping systems data transmission serves collect field parameters water flow rate global irradiation inclined horizontal surface voltage current photovoltaic field ambient temperature various existing techniques studied especially satellite radio gsm global system mobile communication gprs general packet radio service system hardware software application test performance described system used reading storing analyzing information several stations water pumping located remote areas arid region south tunisia integrated system constitute complete data base different parameters related water pumping systems tunisia data could available internet interested parties published elsevier ltd selection peer review responsibility iswee
adolescence key developmental period preventing substance use initiation however prevention programs solely providing educational information dangers substance use rarely change adolescent substance use behaviors recent research suggests mind body practices yoga may beneficial effects several substance use risk factors practices may serve promising interventions preventing adolescent substance use primary aim present study test efficacy yoga reducing substance use risk factors early adolescence seventh grade students public school randomly assigned classroom receive either session yoga intervention place regular physical education classes continue physical education usual participants female white completed pre post intervention questionnaires assessing emotional self regulation perceived stress mood impairment impulsivity substance use willingness actual substance use participants also completed questionnaires months year post intervention results revealed participants control condition significantly willing try smoking cigarettes immediately post intervention participants yoga condition immediate pre post intervention differences emerge remaining outcomes however long term follow analyses revealed pattern delayed effects females yoga condition males control condition demonstrated improvements emotional self control findings suggest school based yoga may beneficial effects regard preventing males females willingness smoke cigarettes well improving emotional self control females however additional research required particularly regard potential long term effects mind body interventions school settings present study contributes literature adolescence examining school based yoga novel prevention program substance use risk factors
much written optimization instance formats mps standard linear mixed integer programs well known around many years extensible formats available optimization categories stochastic nonlinear programming however problem instance piece information shared instance generator solver solver options solver results must also communicated knowledge commonly accepted format representing either solver options solver results paper propose framework theory solver option solver result representation modern distributed computing environment software implementation framework available open source coin project
government response child abuse neglect seen one daunting challenges public policy law legislative reform issue struggles adequately protect children preserving integrity family authors utilize child abuse prevention treatment act capta example funding policy challenges reforming federal child welfare law well lens advocates locate conventional unconventional tools move forward capta examined important weak flawed federal statute authors present array opportunities improve capta next reauthorization cycle noting exemplary successes recent related legislation reforms suggested capta effectively address ongoing challenges child welfare
major drawback replication based raid redundant arrays independent disks architectures spite high redundancy level balance load increased disk failures results reliability access bandwidth reduction processing data access requests furthermore schemes able determine actual position occurring data block errors error data blocks paper alleviate addressed problems propose new parity based striped mirroring scheme called psm raid striped data blocks replicated among disks parity block associated stripe method data mirroring scheme improves reliability array directing read requests mirrored copy data parity data enables controller determine actual position error blocks specific data distribution algorithm proposed paper also improves access bandwidth array serve many disk requests proposed method compared similar architectures simulation results show proposed model due data striping scheme able provide significantly higher parallelism disk requests well higher reliability due block mirroring scheme parity blocks elsevier rights reserved
marker less motion capture seen great progress state art approaches fail reliably track articulated human body motion low number cameras let alone applied outdoor scenes general background paper propose method accurate marker less capture articulated skeleton motion several subjects general scenes indoors outdoors even input filmed two cameras new algorithm combines strengths discriminative image based joint detection method model based generative motion tracking algorithm unified pose optimization energy discriminative part based pose detection method implemented using convolutional networks convnet estimates unary potentials joint kinematic skeleton model unary potentials serve basis probabilistic extraction pose constraints tracking using weighted sampling pose posterior guided model final energy combine constraints appearance based model image similarity term poses computed efficiently using iterative local optimization since joint detection trained convnet fast since formulation yields combined pose estimation energy analytic derivatives combination enables track full articulated joint angles state art accuracy temporal stability low number cameras method efficient lends implementation parallel computing hardware gpus test method extensively show advantages related work many indoor outdoor data sets captured well data sets made available community research labs availability good evaluation data sets paramount scientific progress many existing test data sets focus controlled indoor settings feature much variety scenes often lack large corpus data ground truth annotation therefore contribute new extensive test data set called mpi marconi indoor outdoor marker less motion capture features scenes varying complexity varying camera count features ground truth reference data different modalities ranging manual joint annotations marker based motion capture results new method tested data data set made available community
lives two century cousins changed names bernard berenson considered historical psychodynamic perspectives using psychobiographical method jewish cousins immigrated separately boston lithuania one cousin later calling simply became world renowned art historian bernard became misanthrope feeling deeply humiliated cousin family boston many biographies written famous histories cousin bernard family stories author great grandfather intersecting lives cousins discussed men faced challenges immigration well intense antisemitism prejudice country lived cultural historical conditions interacted cousins narcissistic vulnerabilities lives demonstrate different manifestations narcissistic suffering consistent construct grandiose narcissist bernard consistent closet narcissist life stories two cousins name offers intriguing instance complicated relationship among immigration prejudice narcissism case examples manifestation narcissistic suffering influence lives
since turn millennium interest collaborative distributed conceptualisations leadership gathered momentum particularly education period higher education institutions embedded practices shaped new public management resultant reconfiguration structural arrangements within institutions led existence two staff groups professional academic former often aligned rise managerial practices claimed academic collegial practices thus creating conditions possible dualistic positioning two groups distributed leadership collaboration claimed approaches overcome dualism yet may also susceptible maintaining dual state subtly reaffirm embedded interests structures alternative leadership practice approach ontologically shifts way sense made organisations practice based model understanding organisations presented paper offers theoretical applied framework incorporates also goes beyond collaborative distributed leadership due association practice theory
regulation dendritic spines important component synaptic function plasticity whereas dendritic spine dysregulation related several psychiatric neurological diseases present study tested hypothesis serotonin receptor induced rho family transamidation activation regulates dendritic spine morphology activation multiple types receptors induce transglutaminase tgase catalyzed transamidation small proteins previously reported novel hta receptor downstream effector tgase catalyzed serotonylation small protein racl cells rat embryonic cortical cell line extend findings rat primary cortical cultures develop dendritic spines stimulation hta receptors increased transamidation racl cdc rhoa inhibition tgases significantly decreased transamidation activation racl cdc suggesting transamidation led activation primary cortical cultures stimulation hta receptors dimethoxy iodophenyl aminopropane doi caused transient dendritic spine enlargement blocked tgase inhibition stimulation hta htc receptors contributed doi induced raci transamidation primary cortical cultures demonstrated selective antagonists furthermore stimulation muscarinic acetylcholine receptors nmda receptors also increased tgase catalyzed raci activation syy cells cells respectively receptor stimulated tgase catalyzed transamidation racl occurs site previously reported important inactivation racl studies demonstrate tgase catalyzed transamidation activation small proteins results stimulation multiple types receptors novel signaling pathway regulate dendritic spine morphology plasticity elsevier ltd rights reserved
building envelope selection greatly influences building performance specifically envelope wall system ews definition critical part selection especially residential projects selection complex decision depends multiple considerations cost structural behavior energy efficiency involves multiple stakeholders developers constructors users simplified approaches considering criteria often used decision making process potentially leading suboptimal solutions literature points relevant criteria however need present integrated approach ews selection problem initial step research presents case study identifies formalizes criteria selecting ewss chile assesses preference chilean decision makers criteria via interviews surveys results include thermal acoustic structural behaviors cost complexity construction safety environmental impact durability appearance important criterion structural behavior least important one complexity case study expedite better comprehensive assessment ewss support structured traceable decision making methodology american society civil engineers
cyclic stability key factor design thermochemical heat storage systems carbon dioxide may react heat storage materials lead decrease energy storage efficiency effect cao mgo systems investigated study experimental results show reacts cao water vapor appears heat release process therefore design cao systems cleared system results mgo systems show slightly reacts mgo heat storage release processes study indicates carbonic acid hco could easily react cao form caco heat release processes generally remaining reduces reversibility cao systems slight influence mgo systems addition experimental results show carbonate shell exist rehydration cao mgo samples influence entire process increases cycle elsevier ltd rights reserved
introduction aim study evaluate effects serum insulin serum thyroid profile dietary supplement myo inositol given alone combination melatonin women menopausal transition methods forty women aged years least months amenorrhea enrolled study randomly assigned two groups one group took myo inositol myo ins twice day group took myo ins plus melatonin sleeping beginning study months women evaluated following indices waist circumference body mass index blood pressure endometrial thickness well serum concentrations tsh insulin results baseline months two groups statistically similar considered indices percent changes months baseline contrasted two groups serum tsh decreased myo ins group increased latter serum insulin decreased groups conclusions combination myo ins plus melatonin seems affect positively glucose metabolism myo ins seems improve thyroid function
introduction abnormal uterine bleeding aub commonest menstrual problem perimenopause international federation gynaecology obstetrics working group menstrual disorders developed classification system palm coein causes aub non gravid women present study conducted aim study two components system clinical practice general establish clinico pathological correlation aub context palm component particular materials methods two hundred thirty six perimenopausal women aged years till year beyond menopause admitted complaints abnormal uterine bleeding studied thorough history examination clinical diagnosis made per palmcoein classification relative contribution various causes palm structural coein functional components analysed indicated investigations endometrial sampling hysterectomy specimen assessed histology clinicopathological correlation analysed statistically result palm coein components contributed almost equally aub assessed clinically hand histological examination revealed significantly cases palm structural anatomical component aub versus difference mainly attributed detection cases aub malignancy hyperplasia highly significant proportions coexistent cases aub aub commonest aetiology overall conclusion palm coein classification system take account clinical histopathological diagnoses women aub around perimenopause two diagnostic modalities complementary clinical impression placed proper perspective classification order optimise outcome
unintended pregnancy global sexual health problem outcomes unintended pregnancy include unwanted childbirth abortion may associated negative physical psychosocial health implications women scotland scottish sexual health strategy stated goal improving sexual health people scotland one aim strategy reduce rates unintended pregnancy one policy designed achieve widening access emergency contraception paper examines success policy reference implicit link makes expanding access emergency contraception increasing effective use aiming thereby reduce rates unintended pregnancy since evidence past policies strategies expanding access failed reduce rates alternative approaches discussed
healthy sexual development important adolescents without disabilities yet topic sexuality often ignored disabled population adolescents mild moderate degrees disability rates sexual activity reproductive health needs comparable typically developing peers need support risk reduction education sexual health may exceed peers medical provider may support healthy sexual development education anticipatory guidance menstrual contraceptive management expanding notion sexuality include broader conceptualization sexual behavior expression
digital image correlation dic one widely used non invasive methods measuring full field surface strains wide variety applications dic method used numerous researchers measuring strains plastic range deformation strains relatively large estimation amount background strain error measurements prime importance determining applicability method measuring small strains elastic strains metals ceramics bone samples etc study strain errors dic measurements associated different types imaging systems investigated plane rigid body translation experiments used estimate overall amount error dic displacement strain measurements different types cameras different types sensors different spatial resolutions used study also type camera different types lenses used results show dic measurement accuracy depends magnitude image displacement different error estimation parameters used quantifying accuracy measurements also effect lens measurement accuracy pronounced camera furthermore imaging conditions image sharpness camera gain also affect accuracy still measurement accuracy found influenced direction translation results indicate measurement error reduced orienting camera major displacement direction parallel width direction image experimental approach used study used quantitatively assessing quality different types cameras lenses determine suitability use experimental techniques depend image analysis dic particle image velocimetry piv
introduction alcohol consumption adolescents risky behavior prevented objective determine health care alcohol consumption pattern early adolescence relation determinants health biological environmental social health system factors method qualitative quantitative crosssectional study carried four schools belonging popular council mario gutierrez ardaya health sector may study universe made adolescents aged sample determined simple randomized sampling surveys administered adolescents parents educators senior health staff members determine alcohol consumption medical care quality level knowledge problem nominal group health professionals created results two hundred eighty eight adolescents included alcohol users years old classified low risk prevailing senior health staff expressed need methodology care education staff considered adolescence vulnerable stage relatives reported adolescent specific medical appointments nominal group important opinions based main features consultation adolescents problems hindering proper care conclusions alcohol consumption considered high early start prevailed insufficient care early adolescents use alcohol made evident
background whereas childhood adversity hypothalamus pituitary adrenal hpa axis suggested play major role etiology non suicidal self injury nssi study thus far investigated associations interactions adolescent nssi method investigated antipathy neglect physical psychological sexual abuse indices hpa axis activity salivary hair cortisol clinical sample adolescents engaging nssi age gender matched healthy controls used standardized interviews assessment ceca nssi sitbi axis diagnoses mini kid salivary cortisol sampling surveyed using monitoring system instructed via telephone calls results adolescents engaging nssi exhibited significantly higher cortisol awakening responses compared differences found respect diurnal slope hair cortisol presence healthy adolescents showed flatted diurnal cortisol slopes engaging nssi exhibited significantly steeper ones conclusions findings indicate adolescents engaging nssi may exhibit stronger cortisol awakening response potentially expectation strain however elevated cortisol levels may maintained throughout day especially among adolescents history elsevier ltd rights reserved
discovery key roles interleukin producing cells inflammation autoimmune diseases host defense led experimental targeting pathway animal models diseases well clinical trials humans therapeutic agents include biological products target upstream regulator production producing helper cells cells distinct lineage lineages suggested represent good drug target certain inflammatory conditions targeting proven good approach anti fda approved treatment psoriasis host defense shown mostly beneficial infection caused extracellular bacteria fungi review overview discovery receptors used cytokine role mucosal immunity inflammation elsevier rights reserved
order ensure reliable operation electric power grid infrastructure increasing levels distributed generation deployment various entities subsystems isos distribution utilities micro grids needs higher level coordination coordination requires formal decentralized control management architecture creates mechanisms operation planning numerous entities key function power system operations planning determination total transfer capability ttc maximum amount power transferred set source points set sink points paper develops algorithm decentralized computation ttc application domain decomposition method ddm ddm decouples correlation among interconnected control areas taking advantage schur complement matrix form power transfer distribution factor matrix decentralized ttc evaluation requires sparse information exchange among control areas efficient fully parallelizable demonstrate decentralized ttc evaluation method ieee bus test case
microgrids assisted renewable energy resources complex man made systems various interconnected components number real life scenarios relating resource management microgrids modeled multi objective optimization formulations multiple objectives may may conflict considering type application input output problem nature optimization problem changes address various types optimization problems relating microgid design planning operation exist number optimization solution types investigate existing literature classify different optimization objectives respect designing planning operation microgrids mathematical formulations commonly used objectives relating resource management microgrids tabulated also classified optimization types used address various optimization problems relating resource management microgrids various types solution approaches along relevant simulation tools also presented also reviewed multicriteria optimization different application areas smart grid article serve foundation research area multicriteria decision making relating resource management micrgorids
purpose effectiveness financial benefit pharmacist led annual wellness visits awvs conjunction comprehensive medication management cmm older high risk patients examined methods eligible patients years age older three chronic medical conditions taking five long term prescription nonprescription medications receiving primary care retirement community clinic intervention involved two components awv cmm awv included medicare required components participants saw clinical pharmacist practitioner awv cmm additional cmm visits three six months outcomes included completion required awv components prevalence medication related problems mrps classic return investment patient satisfaction change rate hospitalization results eligible patients contacted agreed participate patients mean age years patients used median medications range baseline pharmacist identified least mrp patients awv patients least mrp identified six months total mrps identified suboptimal drug insufficient therapeutic monitoring undertreatment chronic condition suboptimal dose frequency administration revenue generated pharmacist exceeded costs rate hospitalizations significantly change intervention conclusion pharmacists played beneficial role provision awvs cmm facilitating completion wellness visits identifying addressing mrps older high risk population
remains unclear whether body dissatisfaction widely recognized predictor eating related pathologies depressive symptomatology consistent across cohorts time question important investigate dominant theories propose sociocultural influences may fluctuate play important role development body dissatisfaction previous efforts tracking body dissatisfaction across cohorts time limited relying data single institution using assessments lack psychometric support across genders study utilized cross temporal meta analyses examine changes dimensions body dissatisfaction thinness oriented dissatisfaction assessed eating disorder inventory body dissatisfaction subscale data available across years unique samples participants muscularity oriented dissatisfaction measured drive muscularity scale data available across years unique samples participants results revealed significant interaction year study gender predicting thinness oriented dissatisfaction girls women scored higher boys men consistently although girls women scores decreased gradually across time boys men scored higher girls women muscularity oriented dissatisfaction significant changes across time patterns remained controlling age geographic location overall findings highlight importance considering multiple dimensions body dissatisfaction research offer evidence sociocultural shifts body acceptance diversity may countering thinness related pressures girls women
present study used study test recognition memory task examine brain regions engaged episodic associative memory processes participants evaluated six point rating scale confident whether item presented previous study phase neural activations high low confidence decisions examined old new items two levels item associations items different amounts associations within stimulus set associations defined occurrence statistics medial frontal gyrus posterior cingulate gyrus superior temporal gyrus right hippocampus revealed shaped activation functions greater activations high confidence old new decisions independent associative memory manipulation suggests episodic memory rather processes related confidence account activation brain regions contrast left hippocampus followed different activation pattern modulated amount associations provides evidence role left hippocampus associative memory elsevier rights reserved
paper concerned hamilton principle inelastic bodies conservative external forces inelasticity described internal variable theory rice mech phys solids influence strain change temperature field ignored unlike hamilton principle elastic bodies explicit lagrangian hamilton principle inelastic bodies generally explicit lagrangian based entropy inequality quasi hamilton principle inelastic bodies established form inequality explicit lagrangian lagrangian elastic bodies replacing strain energy free energy quasi hamilton principle inelastic bodies states actual motion distinguished making action maximum evolution equations internal variables recovered quasi hamilton principle
objectivesto investigate whether association congenital heart disease chd placental abnormalities methodswe conducted case control study included cases infants chd underwent cardiac surgery within months life johns hopkins medical center gestational age matched normal pregnancy controls neonates per group resultsoverall abnormal placental cord insertion eccentric marginal velamentous associated chd odds ratio main cardiac defects associated abnormal cord insertion conotruncal defects relative risk confidence interval left heart disease relative risk right heart disease relative risk placenta birth weight ratio associated chd intrauterine growth restriction associated chd odds ratio conclusionsabnormal cord insertion well intrauterine growth restriction determined correlated presence chd basis results conclude cord insertion evaluated routine obstetric sonography fetal heart evaluation warranted abnormal cord insertion detected
increasing public attention brought bear solid waste management macau due continually increasing generation amount limited space study discussed residents attitudes willingness pay wtp solid waste management questionnaire survey results showed macau residents owned relatively high environmental awareness regard macau environmental quality respondents expressed satisfactions current situation respondents thought solid waste pollution macau paid attention three environmental pollution ways air pollution water pollution soil pollution survey data revealed positive attitudes toward source separation macau respondents willing sort solid waste home government required addition question improve solid waste issues macau enhancing residents environmental awareness considered effective method accounting respondents study respondents also provided positive answers questions wtp using logistic regression method survey results support hypothesis probability respondents saying yes wtp question increases education level monthly mean wtp mop per household annual wtp approximately million mop macau results study help managers develop effective environmental management policies solid waste disposal
objectives increased consumption carbohydrates craving sweets considered core features winter depression unfortunately little known neural behavioral correlates symptoms primary aim present study evaluate taste responses sucrose solutions depressed patients seasonal affective disorder sad methods intensity pleasantness ratings sucrose solutions electrogustometric thresholds taste identification abilities assessed depressed patients sad non seasonal affective disorder non sad non depressed controls results electrogustometric thresholds identification abilities differ study groups differences groups intensity pleasantness ratings sucrose solutions proportion sweet likers subjects rating highest sucrose concentration pleasant similar controls sad non sad patients discussion present results suggest winter depression associated major alterations gustatory function sweet craving increased consumption carbohydrates patients winter depression secondary altered responses sweet tastants studies needed characterize hedonic responses patients sad sweet non sweet foods
levodopa induced dyskinesia lid disabling motor complication occurring parkinson disease patients long term dopa treatment although etiology remains unclear accumulating evidence lid relies excessive dopamine receptor transmission particularly downstream signaling receptors previously reported pharmacological blockade alpha reductase rate limiting enzyme neurosteroids synthesis rescued number behavioral aberrations induced receptor selective non selective agonists without inducing extrapyramidal symptoms thus present study designed verify whether inhibitor finasteride fin may counteract dyskinesias induced dopaminergic agonists hydroxydopamine ohda lesioned rats first assessed acute chronic effect different doses fin lid male ohda lesioned dyskinetic rats thereafter fully characterize therapeutic potential fin lid impact dopa efficacy assessed abnormal involuntary movements forelimb use hemiparkinsonian male rats chronically injected fin days either prior concomitant dopa administration addition investigate whether impact fin lid may ascribed modulation receptor function dyskinesias assessed dopa primed ohda lesioned rats received fin combination selective direct dopaminergic agonists finally set investigate whether fin may produce similar effect female hemiparkinsonian rats seen males results indicated fin administrations significantly dampened lid tested treatment regimens without interfering ability dopa ameliorate forelimb use stepping test antidyskinetic effect appears due modulation receptor function fin also reduced abnormal involuntary movements induced selective receptor agonist skf receptor agonist ropinirole significant dampening lid also observed female rats although higher tested dose clinical investigations warranted assess whether similar protection dyskinesia seen patients elsevier inc rights reserved
nowadays ict becoming key factor enhance energy optimization cities district level real time information accessed monitor control energy distribution network moreover fine grain monitoring control done building level provide additional information develop efficient control policies energy distribution district paper present distributed software infrastructure district energy management aims provide digital archive city energetic information available information considered input decision system aims increase energy efficiency promoting local balancing shaving peak loads case study integrated proposed cloud heating distribution network turin present exploitable options based real world environmental data increase energy efficiency minimize peak request
objective chronic fatigue syndrome cfs symptoms shown exacerbated stress ameliorated group based psychosocial interventions cognitive behavioral stress management cbsm still patients may difficulty attending face face groups study compared effects telephone delivered cbsm live cbsm group perceived stress symptomology adults cfs methods intervention data patients cfs mean age years female participating cbsm cbsm previously conducted randomized clinical trials obtained perceived stress scale pss centers disease control prevention symptom checklist scores compared repeated measures analyses variance adjusted unadjusted analyses results participants across groups showed differences demographic illness variables study entry similar session attendance conditions showed significant reductions pss scores cbsm showing large effect partial epsilon cbsm medium effect partial epsilon cfs symptom frequency severity scores cbsm reported large effect size improvements partial epsilon cbsm showed significant changes time conclusions two different formats delivering group based cbsm live telephone showed reductions perceived stress among patients cfs however live format associated physical symptom improvements specific effects post exertional malaise chills fever restful sleep added value live group format discussed along implications future technology facilitated group interventions population elsevier inc rights reserved
leading organizational change involves many leadership skills literature indicates one basic underlying skill ability form use judgment informed analysis experience literature also indicates constructing implementing good judgment analysis experience requires discretion terms autonomy power however findings field study leaders strong reputations change agents demonstrated difficult change agents autonomy power result introduces critical underexplored dilemmas associated balancing autonomy power leading change article argues balancing might occur change agents learned understand handle dilemmas describes enabling conditions learning furthermore future research agenda indicated elsevier ltd rights reserved
novel variational bayesian mixture experts model robust regression bifurcating piece wise continuous processes introduced mixture experts model powerful model probabilistically splits input space allowing different models operate separate regions however current methods fail safe outliers paper robust mixture experts model proposed consists student mixture models gates student distributed experts trained via bayesian inference student distribution heavier tails gaussian distribution robust outliers noise non normality data using simulated data real data obtained bridge robust mixture experts performs better gaussian counterpart outliers present particular provides robustness outliers two forms unbiased parameter regression models robustness overfitting complex models
although open mindedness generally valued people equally open minded situations open mindedness viewed socially desirable individuals encounter viewpoints compatible conventional social norms however open mindedness viewed less desirable terms individuals encounter viewpoints undermine norms perceived desirability open mindedness also influenced individual personal attitudinal convictions individuals inflate normative appropriateness open mindedness serves reinforce convictions devalue normative appropriateness open mindedness serves contradict convictions conversely normative prohibition closed mindedness exaggerated closed minded orientation threatens individual personal attitudinal convictions minimized reversed closed minded orientation reinforces convictions paradoxically perceived appropriateness open mindedness engendered least part motivation confirm one prior attitudinal convictions evidence attitude justification effect obtained two experiments
introduction birth control pill pill revolutionized options contraception sparking vibrant discussion scientific social science literature media much attention focused issues women rights including ethics personal choice pill also introduced new questions risk shortly introduction risk thromboembolic disease recognized half century controversies relationship pill thromboembolic disease persisted scientific media communities active discussion debate delivery information risk scientific public attention thromboembolism pill dramatic consequences good bad spotlight risk helped change norms regarding public right know assess dangers sparked pill scares linked increased unplanned pregnancy birth abortion rates led change federally mandated policies regarding new contraceptive products studied brought market paper charts narrative thromboembolic risk pill introduction today reviews corresponding media response history story thromboembolic risk pill explored lens science media contemporary social dynamics frame contemporary understanding risk researchers clinicians individuals public elsevier inc rights reserved
plant strategies cope future droughts may enhanced associations roots soil microorganisms including arbuscular mycorrhizal fungi fungi affect crop growth yield together plant physiology soil carbon dynamics water stress actual field conditions well understood well characterized mycorrhizal tomato solanum lycopersicum genotype referred myc mutant nonmycorrhizal tomato genotype rmc grown organic farm deficit irrigation regime control regime replaced evapotranspiration increased marketable tomato yields similar irrigation regimes affect shoot biomass irrigation regimes myc plants higher plant nitrogen phosphorus concentrations higher concentrations leaves fruit set respectively higher stomatal conductance higher photosynthetic rates greater fruit set stem water potential leaf relative water content similar genotypes within irrigation regime three fold higher rates root sap exudation detopped myc plants suggest greater capacity water uptake osmotic driven flow especially deficit irrigation regime root sap exudation rmc nearly absent soil myc plants also slightly higher soil extractable organic microbial biomass anthesis changes soil emissions although latter lower deficit irrigation study provides novel field based evidence indigenous fungi increase crop yield crop water use efficiency season long deficit irrigation thus play important role coping increasingly limited water availability future elsevier rights reserved
binary tree traversal algorithm applied many aspects information encryption network operating systems cluster computing already proposed useful method verify correctness algorithmic programs based isabelle proof assistant dijkstra weakness precondition theory manually derived verified binary tree traversal non recursive algorithms previous work order ensure security non recursive algorithms focus paper construct unified recurrence relations expression preorder order post order binary tree traversal non recursive algorithms recurrence relations expression make easier derive loop invariants three algorithms meanwhile automatically verify correctness three kinds non recursive algorithms using generic proof assistant isabelle work realizes mechanically automatic verification overcomes intricacies weakness manual verification improves verification efficiency ensures trustworthiness reliability algorithm program
paper examines association great recession four measures risk maternal child abuse neglect maternal physical aggression maternal psychological aggression physical neglect mothers supervisory exposure neglect mothers draws rich longitudinal data fragile families child wellbeing study longitudinal birth cohort study families cities african american hispanic non hispanic white study collected information year follow survey great recession interview dates linked two macroeconomic measures great recession national consumer sentiment index local unemployment rate also included wide range socio demographic controls well city fixed effects controls prior parenting results indicate great recession associated increased risk child abuse decreased risk child neglect households social fathers present may particularly adversely affected results also indicate economic uncertainty great recession measured consumer sentiment index unemployment rate direct effects risk abuse neglect mediated individual level measures economic hardship poor mental health elsevier ltd rights reserved
test feasibility acceptability implementing evidence based peer delivered mental health intervention somali women minnesota assess impact intervention mental health received training feasibility study somali female community health workers trained deliver session cognitive behavioral therapy intervention trainers recruited participants community outreach resulting participants intervention self assessed measures mood collected study participants throughout intervention focus groups conducted somali women participated recorded significant improvements mood self reported decreases anxiety increases happiness focus group data showed intervention well received particularly delivered fellow community member participants reported gaining skills problem solving stress reduction anger management participants also felt intervention helped address stigma around mental health community delivery cognitive behavioral therapy community health workers offered acceptable way build positive mental health somali community
distribution systems naturally unbalanced consequence unbalanced loads electrical network use single phase two phase sections uncommon addition detailed representation typical distribution system tens thousands nodes depending area selected study whether three phase representation employed contrasts transmission systems typical sizes terms number nodes much smaller balanced single phase representation sufficient situations thus transmission distribution systems traditionally studied separately approach becoming increasingly inadequate various reasons paper proposes methodology integrates transmission distribution systems common electrical model core methodology single three phase models component branches transformers loads etc interchangeable balanced unbalanced network equivalents allow analyzing specific areas given complete network potential gains brought proposed methodology illustrated application real world electric system
ternary copper containing sulfides cusbs cusns attracted considerable interest since years due high efficiency conversion absorbers solar energy promising thermoelectric materials report therein decomposition study cusbs cusns phases using high temperature situ neutron powder diffraction results obtained heating rate min indicate cusbs decomposes approximate cusbs cusns decomposes approximate sns copper rich sulfide phase sphalerite zns type structure assumed cusns stoichiometry phase decompositions associated sulfur volatilization results cusbs fair agreement recent published data decomposition behavior cusns differs studies terms decomposition temperature thermal stability products reaction finally crystal structure refinements neutron powder diffraction data reported discussed cusns tetrahedrite cusbs phases high temperature form skinnerite cusbs
data entry result errors cause analytic problems delays disseminating research invalid responses lead incorrect statistics statistical conclusions purpose article provide researchers basic strategies avoiding range data entry errors streamlining data collection article identifies basic strategies using microsoft excel inexpensive method data entry used research budgets constrained data files structured range values entered string variables entered researchers may inconsistent way code responses data validation accomplished use restricting response options skipping items avoided using count functions tabulate number valid responses also discuss advantages disadvantages several methods data entry including using web based data entry relational databases
objectives describe current shortcomings clinical research treatment nocturia adults suggest new directions future studies field methods literature search conducted using keywords nocturia nocturnal polyuria sleep hypertension results nocturia waking night void highly prevalent bothersome lower urinary tract symptom luts affecting adults since majority patients diagnosed nocturnal polyuria one underlying causes surprising effect treatments overactive bladder oab bladder outlet obstruction boo disappointing regard nocturia therefore suggest conduct studies nocturic patients treated according underlying pathophysiology antimuscarinics agonists oab symptoms blockers reductase inhibitors men boo caused enlarged prostates desmopressin diuretics continuous positive airway pressure nocturic patients obstructive sleep apnea combinations case combined pathophysiology effect treatment efficacy side effects needs assessed also impact related comorbidities sleep disorders hypertension endocrine functions blood glucose regulation conclusion future research needs subtype nocturic patients order adapt treatment according underlying cause
objectives characterize demographics external causes pediatric sports injury related visits sirvs emergency departments eds analyze effect race ethnicity insurance sirvs eds methods stratified random sample cross sectional survey eds national hospital ambulatory medical care survey conducted patients younger years used visits injury related visits irvs sirvs examined external cause codes actual verbatim text irvs national estimates pediatric irvs obtained using assigned patient visit weights national hospital ambulatory medical care survey databases sudaan software sas institute inc cary results sports injuries resulted million visits annually irvs male sex older age years white race ethnicity associated higher rates sirvs cycling basketball playground injuries football resulted largest numbers sirvs leading diagnoses sirvs included fractures dislocations sprains strains open wounds contusions hispanic race ethnicity associated lower rates sirvs across insurance types controlling demographic factors insurance hispanic children less likely sirv white children odds ratio confidence interval conclusions sports recreation leading causes pediatric irvs hispanic children regardless insurance status lower rates sirvs white children helps explain lower rate nonfatal irvs eds among hispanic youth
structure hydraulic wind power plants involves one several high pressure hydraulic pumps central power generation unit combine energy wind turbines wind speed drops energy generation may significant enough run main generator therefore auxiliary generator generates power storage devices system operation low wind speed highly nonlinear power generation significant paper introduces nonlinear model hydraulic elements offers nonlinear dynamics system operation low speed nonlinear state space representation hydraulic wind energy transfer presented validated experimental implementations
since publication last national burden skin disease report substantial changes practice dermatology health care system include development new treatment modalities marked increases cost medications increasingly complex payer rules regulations aging population recognizing need date data inform researchers policy makers public stakeholders health care providers impact skin disease patients society american academy dermatology produced new national burden skin disease report using claims data private governmental insurance providers report analyzed prevalence cost mortality attributable skin disease categories population first articles presented data demonstrate nearly million americans seen physician least skin disease led estimated direct health care cost billion indirect lost opportunity cost billion mortality noted half skin disease categories
applications remote sensing using unmanned aerial vehicle uav agriculture proved effective efficient way obtaining field information study validated feasibility utilizing multi temporal color images acquired low altitude uav camera system monitor real time wheat growth status map within field spatial variations wheat yield smallholder wheat growers could serve references site specific operations firstly eight orthomosaic images covering small winter wheat field generated monitor wheat growth status heading stage ripening stage hokkaido japan multi temporal orthomosaic images indicated straightforward sense canopy color changes spatial variations tiller densities besides last two orthomosaic images taken two weeks prior harvesting also notified occurrence lodging visual inspection could used generate navigation maps guiding drivers autonomous harvesting vehicles adjust operation speed according specific lodging situations less harvesting loss subsequently orthomosaic images geo referenced study stepwise regression analysis among nine wheat yield samples five color vegetation indices cvi could conducted showed wheat yield correlated four accumulative cvis visible band difference vegetation index vdvi normalized green blue difference index ngbdi green red ratio index grri excess green vegetation index exg coefficient determination rmse respectively average value sampled wheat yield regression model also validated using leave one cross validation loocv method root mean square error predication rmsep finally based stepwise regression model map estimated wheat yield generated within field spatial variations wheat yield usually seen general information soil fertility water potential tiller density etc could better understood applications site specific variable rate operations average yield studied field also calculated according map wheat yield
new small efficient voltage regulator realized using resonant switched capacitor converter technology introduced voltage regulation implemented means simple digital pulse density modulation displays ideal transient response zero order nature disturbance types newly developed topology acts gyrator awide range voltage conversion ratios well unity constant efficiency characteristics entire operation range operation voltage regulator verified experimental prototype demonstrating ideal transient recovery without undershoots response load line transients simple design guidelines voltage regulation system provided verified experiments
paper presents equivalent magnetic circuit model predict leakage effect especially end leakage effect surface mounted permanent magnet synchronous machine spmsm rim driven marine current power rmcp system end leakage effect usually neglected conventional permanent magnet machines however significant electrical generator rpcm due short axial length idealized path analytical expressions end leakage permeance given paper finite element method fem values presented validate proposed analytical model need time consuming fem calculation correction factor base analytical mode proposed adjust results back emf torque conventional design end leakage ignored calculation calculation results experimental dines show proposed analytical model accurate analyze leakage effects spmsm rmcp system
article explores therapeutic impasse dual lens relational theory infant research particular attention paid role enactment rupture repair nonverbal communication play impasse dynamics defined broadly time therapist patient feel stuck impasse conceptualized expectable even inevitable component treatment relationship implications navigating impasses considered clinical vignette developed case composite ensure confidentiality
many indications discussed vitamin substitution osteoporosis autoimmune diseases cancer psychiatric diseases also discussed fact majority german population suffer vitamin deficiency review study results individual diseases critical analysis currently established therapeutic reference range defines vitamin deficiency literature search carried statements german society nutrition scientific publications journals study results prevention therapy various diseases vitamin show inconsistent results well established indications prevention rickets babies supportive therapy osteoporosis currently established reference range definition vitamin deficiency came studies vitamin deficiency correlated increase parathyroid hormone different laboratories use different methods measurement vitamin levels studies needed clarify role vitamin prevention treatment various diseases another problem different laboratories use measurement methods determine vitamin use different methods leads widely varying results compared therefore standardization methods would desirable
green roofs gaining momentum arid semi arid regions due multiple benefits compared conventional roofs one critical steps green roof installation selection drought heat tolerant species thrive extreme microclimate conditions monitored water status growth survival drought adapted shrub species grown shallow green roof modules deep substrate analyzed traits enabling plants cope drought symplastic apoplastic resistance heat stress root membrane stability physiological traits conferring efficiency safety water transport system severe drought influenced plant water status represent good predictors plant water use growth rates green roofs moreover data suggest high substrate temperature represents stress factor affecting plant survival larger extent drought per fact major cause influencing seedling survival shallow substrates species specific root resistance heat single easy measurable trait integrated methodological framework screening selection suitable shrub species roof greening mediterranean elsevier rights reserved
health related quality life hrqol represents individual perception physical mental social well strong predictor health status studies examined associations sedentary behavior moderate vigorous physical activity mvpa hrqol general population study aimed determine combined associations objectively measured mvpa risk poor hrqol general population controlling potential confounding factors analyzed data adults national health nutrition examination survey hrqol measured using hrqol consisting four questions focused self perception general health physical health mental health activity limitation dichotomized hrqol component good versus poor defined poor overall hrqol participants poor hrqol components mvpa measured using accelerometer survey logistic models examined estimate odds ratio confidence interval poor hrqol mvpa tertiles examined combination mvpa substantial decrease risk poor overall hrqol found individuals low high mvpa moderate high mvpa significant decrease found individuals high high mvpa high low mvpa findings suggest increasing mvpa reducing time spent may useful strategies improve hrqol
problems sustainable development today identified tried solve fields life respect information technologies play specific role many studies devoted analysis information technology ict tools sustainable development different contributions threats posed ict sustainable development discussed however methodological legislative base software development sufficiently researched perspective sustainable development information technologies paper presents literature review conference journal articles materials international projects topic different ict roles sustainable development review shows lack regulatory framework analysis information technologies analysis done separate part present paper found analysed weaknesses evolution software development methods put marketing considerations first plan basis done analysis discuss possible future work put sustainable foundations information technology knowledge beginning ict specialists training
objective aim study propose analysis route curvature essure system ultrasound determine correct location miss tubal perforation methods retrospective single center study years analyzing ultrasound performed single sonographer implant placement performed different operators one prescribed ultrasound control case difficulties installation indications systematics results essure position right cases twenty eight implants appear incorrectly positioned ultrasound positioning abnormalities found described classification proposed literature one case curvature implant taking account classification allowed evoke tubal perforation among cases non visualized implants place cases wrong position implant confirmed additional examinations laparoscopy hsg cases asp hsg disproved wrong position implants cases complementary examinations conclusion ultrasonography seems method choice control implants simple implementation good reproducibility however interpretation ultrasound images sometimes difficult study curvature implant systematically analyzed miss tubal perforation elsevier masson sas rights reserved
introduction feed tariff fit support mechanism spurred development small scale domestic renewable electricity generation throughout great britain however spatial pattern uptake uneven suggesting local well neighbourhood factors may important well confirming local socio economic factors including wealth housing type population density found important explaining uptake policy local green attitudes measured three different ways shown important existing local technical expertise proxied using data small scale renewable electricity devices area prior introduction fit important factor explaining subsequent adoption critically also find spatial neighbourhood processes explaining uptake technologies taken together results suggest currently designed fit policy may regressive income could exacerbate spatial economic inequalities
mutations trem gene confer risk alzheimer disease susceptibility parkinson disease evaluated effect trem deletion methyl phenyl tetrahydropyridine mptp induced mouse model measuring neurodegeneration microglia activation using combined vivo imaging postmortem molecular approach wild type mice mptp administration induced progressive decrease fecit uptake culminating day neuronal loss accompanied increase trem beta translocator protein tspo transcript levels binding gfap staining day early transient increase tnf alpha galectin iba day trem null trem mice mptp similarly affected neuron viability microglial cells shown lower level iba staining basal condition reduced increment iba tnf alpha beta response mptp likely compensate trem absence trem mice showed earlier increment binding significant increase taken together data demonstrate central role trem regulation microglia response acute neurotoxic insults suggest potential modulatory role tspo response immune system deficit elsevier inc rights reserved
one two dimensional mems scanning mirrors resonant quasi stationary beam deflection primarily known tiny micromirror devices aperture sizes millimeters usually address low power applications high volume markets laser beam scanning pico projectors gesture recognition systems contrast recently reported vacuum packaged mems scanners feature mirror diameters integrated high reflectivity dielectric coatings mirrors enable mems based scanning applications require large apertures due optical constraints like sensing microscopy well high power laser applications like laser phosphor displays automotive lighting displays printing general laser material processing work presents modelling control design experimental characterization gimbal less mems mirrors large aperture size example resonant biaxial quadpod scanner mirror diameter four integrated pzt lead zirconate titanate actuators analyzed finite element method fem model developed computed comsol multiphysics used calculating eigenmodes mirror well extracting high order state space representation mirror dynamics actuation voltages system inputs scanner displacement system output applying model order reduction techniques using matlab compact state space system approximation order computed based reduced order model feedforward control inputs different properly chosen scanner displacement trajectories derived tested using original fem model well micromirror
given prevalence violence young children lives detrimental effects violence exposure may children development essential psychologists disseminate information direct contact young children one antiviolence program adults children together act violence training program aimed specifically role models young children lives parents caregivers teachers others work directly research examined utility act program disseminating knowledge early childhood professionals results revealed program effective terms participants increase knowledge perception knowledge regarding violence childhood preliminary support utility act training program psychologists working young children provided
coccidioides virulent dimorphic fungus causes coccidioidomycosis valley fever mammals including humans although genome sequenced proteomic analysis exist address gap proteomic knowledge generated proteome spherulin well studied lysate fungal spherules identified proteins proteins included glycosylation enzymes led hypothesize fungal glycosylation patterns may different mammals could exploited detect coccidioides tissues performed lectin based immunohistochemistry formalin fixed paraffin embedded human patients lung tissues gsl criffonia simplificonia lectin swga succinylated wheat germ agglutinin lectins bound specifically endospores spherules infected lungs identify lectin binding glycoproteins spherulin performed lectin affinity chromatography followed total glycoproteins spherulin bound gsl glycoproteins bound swga glycoproteins bound lectins first report specific reactivity gsl swga lectins coccidioides endospores spherules infected human tissues first listing coccidioidal proteome spherulin using sequences present three coccidioides databases refseq swissprot broad institute coccidioides genome project
effects quantitative feed restriction digestive physiology young rabbit remain largely unclear several digestive functions thus analysed rabbit weaning using monofactorial design produces linear reduction intake libitum group restriction programme applied giving daily meal days weaning days day transition period managed feed intake fixed group fed libitum till days age young rabbit quickly adapted restriction programme since within days weaning ate totally ration within feed distribution animals consumed feed days old rabbits groups reached intake group within day feed intake restricted animals increased progressively without eating days old intake four groups differ averaged day per rabbit restriction live weight weight gain decreased linearly restriction level days weight gain increased linearly according restriction level previously applied final weight restricted rabbits remained lower ones respectively days restriction digestibility significantly affected restriction level except crude protein presented slightly higher unit coefficient groups mean retention time mrt particles increased restricted animals mean compared ones liquid phase three times longer particles linearly moderately increased restriction restricted groups caecal lower unit could related higher volatile fatty acid vfa concentration mmol compared fermentation pattern ammonia concentration caecal bacterial fibrolytic activity remained similar among treatments although butyrate proportion tended higher restricted animals impact feed restriction performances digestive health reported second part study
research summary use variance decomposition methodology assess degree board chairs may influence companies performance isolate board chair effect focus firms ceo board chair positions separated using sample firm year observations representing board chairs different industries results indicate board chair effect substantial nine percent drawing resource dependency theory also theorize show board chair effect contingent task environment firms operate results add literature examining role influence board chairs context chairs may greater impact performance managerial summary following institutional regulatory changes firms separating ceo board chair positions increasing number individuals separate ceo serving board chairs critical question becomes influence separate board chairs firm performance prior research suggests separate board chairs provide important resourcesincluding advice counsel legitimacy information linkages preferential access external commitments supportto ceos top managers overall firms turn board chair individual ability lack thereof provide resources may significant impact firm performance offering support perspective find separate board chairs explain nine percent variance firm performance copyright john wiley sons ltd
cimicifuga racemosa extracts important worldwide therapy menopausal symptoms first medicinal product available since germany remifemina schaper brummer salzgitter germany isopropanolic extract icr review describes developed via clinical studies safety breast breast cancer endometrium liver efficacy successful safe medicinal product germany europe world line developing legal frameworks medicinal products germany europe clinical studies observational controlled studies since first placebo controlled study emerged total clinical studies europe america asia published efficacy studies patients received based medicinal product thereof icr meta analysis nine placebo controlled studies published confirmed reliable efficacy based medicinal products menopausal symptoms
achieving beautiful skin longer confined wearing make applying anti ageing creams hide reverse unkindly visible greater knowledge urban lifestyles encouraging consumers healthy skin times perhaps driving beauty industry align proactively healthcare dermocosmetics key beauty categories namely skin care sun care among dynamic segments going forward may detriment remedial options anti agers typically purview cosmetics brands
consider problem automatically identifying person interest seen probe camera view among several candidate people gallery camera view problem called person identification fundamental importance several video analytics applications extracting knowledge high dimensional visual representations based notions sparsity regularization successful several computer vision problems techniques fully exploited context identification problem develop principled algorithm identification problem general framework learning sparse visual representations given set feature vectors person one camera view corresponding multiple images tracked show feature vector representing person another view approximately lies linear span feature set furthermore certain conditions associated coefficient vector characterized block sparse key insight allows design algorithm based block sparse recovery achieves stateof art results multi shot person identification also revisit older feature transformation technique fisher discriminant analysis show combined proposed formulation outperforms many sophisticated methods additionally show proposed algorithm flexible used conjunction existing metric learning algorithms resulting improved ranking performance perform extensive experiments several publicly available datasets evaluate proposed algorithm elsevier rights reserved
shape memory alloys smas thermally activated show strong thermomechanical coupling relationship strain stress temperature sma wires commonly used develop sma based actuators important characteristics sma wires capability exert linear forces strokes original length make smas attractive smart material actuation purposes however main weakness smas limitation actuation bandwidth limitation comes rate sma wires able heat cool releasing heat energy surroundings paper focuses effects different heating cooling rates sma wire working rate attained sma wire experimentally tested different conditions heating cooling applied load find influence parameters contraction cooling times sma wire therefore attainable frequency addition model smas implemented finite element analysis software experiments also simulated used corroborate conclusions drawn experiments
purpose study develop new method designing compression sportswear viewpoint force simulation applied simulation techniques skin strain simulation fabric strain simulation using anisotropic hyperelastic model musculoskeletal simulation skin strain simulations three dimensional computer graphic polygon strain calculated skin strain using model simulates human body human model initial strain strain caused physical exercise given polygon model representing shape sportswear sportswear model compression sportswear strain fabric approximately skin strain thus strain human model given sportswear model plane plane forces resulting sportswear model calculated using anisotropic hyperelastic models forces given musculoskeletal simulation external forces muscle activity required given physical exercise swimming motion calculated information forces muscle activity useful designing compression sportswear believed new method designing compression sportswear based simulation sophisticated technique method takes account forces resulting sportswear also effect forces physical exercise authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
past research demonstrated parenting style related children health eating patterns parenting vary across time context however little evidence similarities differences general self reported parenting style observed parenting grocery shopping goals study investigate links general parenting style parental warmth limit setting important dimensions parenting style grocery shopping healthfulness foods chosen participants parent mothers child years old dyads dyads brought laboratory set like grocery store aisle asked choose two items three categories cookies crackers cereals chips snacks parents observed terms warmth responsiveness autonomy granting limit setting children observed terms resistance negotiation parents reported behaviors related general parenting regression analyses used test study hypotheses observed parental limit setting related general parenting style observed warmth observed limit setting observed warmth self reported parenting style related healthfulness food choices limit setting appears dimension parenting style expressed grocery shopping promotes healthier food choices implications discussed regarding consistencies parenting style across situations well contributions parenting style development children healthy eating published elsevier ltd
context pain management suboptimal nursing homes objectives estimate extent receipt hospice nursing homes nhs increases receipt pain management residents cancer end life methods study participants included medicare beneficiaries cancer residents last days life residents pain hospice matched like residents without hospice facility type pain assessment self report staff assessment weeks death matched strata unique residents minimum data set provided information residents pain prevalence receipt pain management scheduled analgesics needed pro nata prn medication nonpharmacologic interventions developed conditional logistic models estimate association hospice use pain management stratified self reported staff assessed pain results found pain prevalence higher residents using hospice versus without hospice residents self reported pain hospice cis nonhospice matched analyses untreated pain uncommon self reported pain hospice users nonusers respectively hospice use associated receipt scheduled analgesics self reported adjusted odds ratio prn medication self reported adjusted odds ratio pain prevalence association hospice pain management similar residents staff assessed pain conclusion untreated pain end life among residents cancer nhs unusual hospice associated increased pain management among documented pain american academy hospice palliative medicine published elsevier inc rights reserved
investigating sleep mental disorders potential reveal disorder specific transdiagnostic psychophysiological mechanisms meta analysis aimed determining polysomnographic psg characteristics several mental disorders relevant studies searched standard strategies controlled psg studies evaluating sleep affective anxiety eating pervasive developmental borderline antisocial personality disorders attention deficit hyperactivity disorder adhd schizophrenia included psg variables sleep continuity depth architecture well rapid eye movement rem sleep considered calculations performed comprehensive meta analysis software using random effects modeling disorder variable separate meta analysis conducted least studies available calculation effect sizes standardized means hedges sources variability sex age mental disorders comorbidity evaluated subgroup analyses sleep alterations evidenced disorders exception adhd seasonal affective disorders sleep continuity problems observed mental disorders sleep depth rem pressure alterations associated affective anxiety autism schizophrenia disorders comorbidity associated enhanced rem sleep pressure inhibition sleep depth sleep parameter exclusively altered condition however conditions shared psg profile sleep continuity disturbances imply transdiagnostic imbalance arousal system likely representing basic dimension mental health sleep depth rem variables might play key role psychiatric comorbidity processes constellations sleep alterations may define distinct disorders better alterations single variable
alcohol use among persons living hiv plwh consequential half plwh reported drink alcohol reported heavy drinking alcohol use plwh associated higher risk non adherence antiretroviral treatment art poor treatment outcomes provide guidance clinicians using evidence based approach intervene ensure follow plwh drink alcohol set clinical strategies known screening brief intervention referral treatment fully disseminated may help address targets proposed joint united nations programme hiv aids particular receipt sustained art attainment viral suppression copyright association nurses aids care
vital construct low carbon city china order mitigate huge cost climate change especially considering great contribution cities national greenhouse gas emissions many chinese cities made efforts construction low carbon city recent years various aspects low carbon practice chinese cities reviewed paper including setting urban low carbon development planning establishing low carbon demonstrative areas focusing specific fields sustainable energy system ecological industry green transportation green building effect low carbon practice also evaluated certain issues requiring concerns discussed expected discussion paper helpful promoting construction low carbon city china authors published elsevier ltd
interactivity learning environment innovative approach teaching learning predominantly theoretical justification interactive learning environment discussed basis process visual auditory information memory system emphasizing result oriented perspective sense given importance computer response learner action rather learner activity engagement computer programming however definition interactivity described act view point present research attempts explore effectiveness enactment manipulating virtual features interactive visualization compared visual animation investigate effectiveness different visual condition researchers developed two different types instructional module interactive virtual manipulation animated visual total students selected implement study different matching criteria manova conducted find group difference different condition result showed momentous mean difference different condition virtual manipulation execution action condition student perform virtually screen object better animation observed action respect various learning outcome result discussed critically several theoretical focal points
purpose researchers argued multicultural marketplaces conceptually different types marketplaces marketing literature recently begun develop multicultural perspective studies little research done examine intergroup complexities consumption contexts demangeot purpose study fill research gap developing empirically testing research model examine effects socio political constructs intergroup based emotional variables consumer decisions consume cross ethnic products design methodology approach questionnaire designed assess effects socio political constructs intergroup based emotional variables consumer decisions consume cross ethnic products developed administered students midwestern university data analysed using partial least squares structural equation modelling pls sem techniques findings results indicate path coefficients significant social dominance intergroup anxiety intergroup experience found important predictors intergroup tolerance importantly intergroup tolerance found significantly affect consumer attitude toward cross ethnic products research limitations implications terms limitations future research implications research suffers inherent limitations associated self reported survey research limited geographic region accordingly study respondents may representative consumers across nation world respondents may understood questions intended manner reported intentions may reflect actual behaviour study conducted among college students target segments may different intergroup experiences perceptions ethnic products practical implications findings research suggest firms offering ethnic products increase crossover consumption appeal implementing marketing communication programmes integrate cultural forums event tactics promote positive intergroup experiences tolerance among multicultural customers social implications regarding policy implications public policymakers social thinkers may use findings study prism better explicate intercultural dealings among multicultural consumers contention study public policy implications supported neal perspectives consumption situations serve lens explicating intergroup emotions multicultural marketplaces originality value one studies marketing assess effects socio political constructs consumption context first known study underscore importance intranational ethnic differences assess effects socio political intergroup based emotional variables attitude consume ethnic products specifically
composite mos hollow carbon sphere mos hcs prepared via glucose assisted one pot synthesis composite consists hierarchical spheres diameter hollow spheres decorated number curled interlaced mos nanosheets composite subject lithium intercalation mos converted phase current work activities mos hcs toward photocatalytic hydrogen evolution reduction dye sensitized solar cells dscs systemically investigated evaluated photocatalyst hydrogen evolution amount evolved hydrogen mos hcs reach mol times higher synthesized mos hcs additionally mos hcs employed counter electrode material dscs dscs based mos hcs possesses power conversion efficiency higher mos hcs comparable study demonstrates mos hcs great potential inexpensive alternative catalysts elsevier rights reserved
although extensively studied postnatally functional differentiation cholecystokinin cck containing interneurons route towards cerebral cortex fetal development incompletely understood used cckbac dsred mice encoding cck promoter driven red fluorescent protein analyze temporal dynamics dsred expression neuronal identity positioning high resolution developmental neuroanatomy additionally developed dual reporter mouse line cckbac dsred gad gfp differentiate cck containing interneurons dsred principal cells prenatal development show dsred upregulated interneurons exit proliferative niche ganglionic eminence remains stably expressed throughout long distance migration towards cerebrum particularly hippocampus dsred interneurons including cohort coexpressing calretinin accumulated palliosubpallial boundary embryonic day pioneer dsred interneurons already reached deep hippocampal layers embryonic day morphologically differentiated birth furthermore probed migrating interneurons entering traversing cortical plate well stationary cells hippocampus patch clamp electrophysiology show first signs channel activity embryonic day reliable adult like excitability embryonic day cumulatively study defines key positional molecular biophysical properties cck interneurons prenatal brain
subgroup discovery key data mining method aims identifying descriptions subsets data show interesting distribution respect pre defined target concept practical applications integration numerical data crucial therefore wide variety interestingness measures proposed literature use numerical attribute target concept however efficient mining setting still open issue paper present novel techniques fast exhaustive subgroup discovery numerical target concept initially survey previously proposed measures setting explore options pruning search space using optimistic estimate bounds specifically introduce novel bounds closed form ordering based bounds new technique derive estimates several types interestingness measures previously known bounds addition investigate efficient data structures namely adapted trees bitset based data representations discuss interdependencies interestingness measures pruning schemes presented techniques incorporated two novel algorithms finally benefits proposed pruning bounds algorithms assessed compared extensive experimental evaluation publicly available datasets novel algorithms reduce runtimes consistently one order magnitude
work carried theoretical analysis reflection transmission surface deformation long linear water waves propagating submerged breakwater whose cross section obeys cycloidal geometric transition use well known one dimensional governing equations propagation linear shallow water waves presented dimensionless version considering harmonic wave propagation governing equations reduced dimensionless second order differential equation variable coefficients predicting elevation water waves equation solved using matrix method based taylor polynomials particular evaluate reflection transmission coefficients three breakwaters namely cycloidal semi cycloidal quarter cycloidal first case exhibits smallest transmission coefficient present mathematical model compared simple numerical solution another analytical solution expressed terms legendre functions present mathematical model used practical reference design geometrical configurations submerged cycloidal breakwaters shallow flow conditions
wind farm layout optimization problem received considerable attention past two decades objective problem determine wind farm layout maximizes annual energy generated majority studies solved problem simulated velocity deficit using jensen wake model however model agreement field measurements computational fluid dynamics simulations study approach solve wind farm layout optimization problem based gaussian wake model proposed gaussian wake model uses exponential function evaluate velocity deficit contrast jensen wake model assumes uniform velocity profile inside wake proposed approach minimizes annual cost energy wind farm using genetic algorithm application proposed approach yields higher annual generation lower computational time wind scenarios study complex wind scenario improvement relatively small suggests use robust wake model wflo problem lead greater efficiency real wind cases elsevier ltd rights reserved
paper reliability contactor studied present scenario dependency electrical energy increased immensely huge pressure power system network reliable operation condition failure component electrical network cause huge loss economy continuity supply paper focused towards estimating remaining useful life contactors characteristics parameter contact resistance contact compression sampies rating coil voltage underwent electrical endurance test testing behavior two characteristic parameters studied accordance find relation contactors life contact resistance contact compression results obtained helped predicting health remaining life contactor hence based experimental data reliability system estimated using reliasoft software
rain barrels technically shared social practices mutual agreement individual households study proposes evaluation system rain barrel sharing network rbsn considering three performance criteria reliability resiliency vulnerability plausible climate change scenarios first study shows system improved terms performance criteria using historical daily rainfall data based storage reliability yield relationship study examined benefits rbsn affected climate change years three climate change scenarios three global circulation models used purpose results showed reliability vulnerability improved due sharing improvements become larger climate change conditions contrast resiliency reduces slightly due sharing reduction attenuated climate change conditions particular vulnerability reduced significantly climate change results suggest sharing various water resources systems effective climate change adaptation strategy reduces vulnerability increases reliability system
current events within military professional sports resulted increased recognition long term debilitating consequences traumatic brain injury mild traumatic brain injury accounts majority head injuries posttraumatic headache common adverse effect estimated traumatic brain injuries result posttraumatic headache significant number people headache disorder continue year post injury often severe chronic posttraumatic headache migraine like phenotype difficult resolve review discuss preclinical findings animal models posttraumatic headache also describe potential mechanisms traumatic brain injury leads chronic posttraumatic headache including neuroinflammatory mediators migraine associated neuropeptides surprisingly preclinical studies investigated overlapping mechanisms posttraumatic headache migraine especially considering prevalence debilitating nature posttraumatic headache given context posttraumatic headache field many emerging opportunities growth frequency posttraumatic headache general military population rising preclinical research required understand ameliorate treat disabling disorder wiley periodicals inc
new type linear oscillating electrical generator proposed electrical power generated help oscillating dielectric batio piston capacitor modulated capacity translational movement piston provided external motor equivalent electrical circuit load characteristics obtained power density dielectric material batio equal oscillation frequency dielectric materials high values dielectric constant also may used
engaging construction based robotics activities children young four play learn range concepts tangiblek robotics program paired developmentally appropriate computer programming robotics tools constructionist curriculum designed engage kindergarten children learning computational thinking robotics programming problem solving paper documents three kindergarten classrooms exposure computer programming concepts explores learning outcomes results point strengths curriculum areas redesign curriculum technologies would appropriate overall study demonstrates kindergartners interested able learn many aspects robotics programming computational thinking tangiblek curriculum design elsevier ltd rights reserved
background sarcopenia proposed prognostic factor outcomes various diseases applied crohn disease aimed assess impact sarcopenia postoperative outcomes bowel resection patients materials methods abdominal computed tomography images within days bowel resection patients may march assessed sarcopenia well visceral fat areas subcutaneous fat areas impact sarcopenia postoperative outcomes evaluated using univariate multivariate analyses results patients sarcopenia patients sarcopenia lower body mass index lower preoperative levels serum albumin major complications compared patients without sarcopenia moreover predictors major postoperative complications sarcopenia odds ratio decreased skeletal muscle index preoperative enteral nutrition preoperative serum albumin level protective factors multivariate analyses conclusion prevalence sarcopenia high patients requiring bowel resection significantly increases risk major postoperative complications clinical implications respect nutrition management surgery
paper describes international facilities design project manufacturing industrial engineering students american turkish engineering students collaborated create implement design turkish wheelchair manufacturing facility company needed engineering assistance improve efficiency increase capacity existing factory turkish industrial engineering students went site collect data draw existing facility layout american manufacturing engineering students analyzed data developed new layout designs four american students traveled turkey semesters implement initial phases design second semester turkish students simulated new layout see performance improvements completing project student learning outcomes positive groups students paper explains critical steps identifying projects partners lessons shown successes shortcomings planning operating communicating design teams across cultures
objective young adult american veterans risk problematic alcohol use however unlikely seek care may drop lengthy multicomponent treatments get care randomized controlled trial tested brief alcohol intervention delivered internet reach population young adult veterans help reduce drinking method veterans recruited facebook randomized either control condition personalized normative feedback pnf intervention seeking correct drinking perceptions gender specific veteran peers results immediate postintervention pnf participants reported greater reductions perceptions peer drinking intentions drink next month compared control participants month follow pnf participants reduced drinking behavior related consequences significantly greater extent controls specifically pnf participants drank fewer drinks per week consumed fewer drinks per occasion binge drank fewer days experienced fewer consequences control participants month intervention intervention effects drinks per occasion pronounced among problematic drinkers changes perceived norms baseline month follow mediated intervention efficacy conclusion though effects assessed month findings potential inform broader population level programs designed young veterans prevent escalation drinking development long term alcohol problems given simplicity pnf approach ease administration intervention potential substantial impact public health
ample research demonstrated empathizing someone need promotes helping person two studies examined whether effect empathy helping behavior holds across different emotional reactions expressed target need results study indicate perspective taking sad needy target increased empathic concern turn fostered helping individual relation found participants taking perspective angry disgusted needy targets study provides support underlying mechanism results study perspective taking sad needy target increased empathizers empathic concern perception target neediness increased pattern found perspective taking angry needy target findings correspond theorizing role emotions person perception hence current research provides insights regarding boundary conditions empathy helping association
neural processes giving rise tohumanmemorystrength signals remain poorly understood inspired formal computational models posit central role global matching memory strength tested novel hypothesis strengths true false memories arise global similarity item neural activation pattern retrieval studied items encoding encoding retrieval neural global pattern similarity ngps revealed multiple ngps signals carried distinct information contributed differentially true false memories whereas ngps parietal regions reflected semantic similarity scaled recognition strengths true false memories ngps visual cortex contributed solely true memory moreover ngps differences parietal visual cortices correlated frontal monitoring processes combining computational neuroimaging approaches results advance mechanistic understanding memory strength recognition
big data solution emerging trend today world provides enterprises certain advantages however achieving straightforward certain challenges due inherited complexity big data paper aims understand benefits potential challenges big data literature review review results common benefits big data competitive advantage degree customer view prediction power cost effective solution deal colossal amount data customized services customers determining customer value adopting suitable marketing campaign prospects cross sell products services similarly common challenges associated lack skills analyze data produce valuable insights addressing need speed privacy concerns data cleansing data integration diversity incompleteness findings expected aid researchers practitioners look advantages challenges involved big data initiating project
according definition buffeting caused fluctuating wind since fluctuating wind wind speed changing time atmosphere cause vibration structure pulsating wind reflects atmospheric boundary layer wind disturbance randomness paper stable type suspension bridge stsb researched buffeting problem finite element model bridge set using finite element software buffeting response bridge calculated studied influence opposite tensional structures bridge buffeting response bridge assessed
objectiveto identify risk factors canine lymphoma dogs new south wales australia compare factors affecting remission duration methodsclient owned dogs diagnosed lymphoma presented university veterinary teaching hospital uvth university sydney compared control population dogs seen period time diagnosis lymphoma evaluate association explanatory variables breed age sex outcome case control status resultsthe australian cattle dog odds ratio confidence interval doberman rottweiler increased odds lymphoma among dogs attending uvth compared crossbreds results suggested border collie boxer also increased odds lymphoma among pure breed dogs attending uvth compared crossbred dogs conclusionsthe results study confirmed breed predilection lymphoma dogs australian cattle dog doberman increased odds lymphoma
nitrogen excretion sheep production systems important source nitrate ammonia nitrous oxide responsible ground water pollution global warming present study aimed identify key parameters influencing utilization efficiency develop prediction equations manure feces urine outputs sheep data used collected sheep offered fresh perennial ryegrass lolium perenne sole diet metabolism experiments data non grassonly diets used sheep breeds highlander texel scottish blackface swaledale age weighing herbage harvested daily swards contrasting harvest dates may december offering wide variation feed value cover range would offered practical farm situations commencement study experimental sward harvested residual height allowed grow target average pregrazing sward height range depending time year sheep housed individual pens transferred individual metabolism crates feed intake feces urine outputs measured data analyzed using linear mixed model procedure develop prediction equations feces urine manure outputs using intake herbage chemical composition digestibility effects sex breed experimental periods removed nitrogen intake best single predictor output feces urine manure value prediction manure output greater feces urine respectively animal herbage ether extract ndf adf water soluble carbohydrate concentrations digestibility also used predict outputs intake may available commercial practice prediction equations utilization efficiency indicated increasing feeding level concentration reducing concentration could improve utilization efficiency shift excretion feces rather urine equations developed current study provide approach sheep producers quantify excretion production consequently develop mitigation strategies reduce environmental impact sheep production systems
possibility using neumann method solve boundary problems thin elastic shells studied variational statement static problems shells allows problem examination within distribution space convergence neumann method proven shells holes boundary domain completely fixed numerical implementation neumann method normally requires significant time reliable results achieved paper suggests way improve convergence process allows parallel computing evaluation calculations
optical soliton shaping process changing waveform transmitted pulses applied optical communication systems make pulse fit communication channels paper concept optical soliton shaping introduced dispersion decreasing fibers sine profile pulse propagation dispersion decreasing fibers described variable coefficient higher order nonlinear schrodinger equation effects third order dispersion self steepening stimulated raman scattering investigated symbolic computation hirota method analytic soliton solutions equation derived adjusting corresponding parameters obtained solutions present optical soliton shaping influences parameters discussed
present work addresses development finite element formulation handling bending buckling post buckling analysis composite laminated structures damage inverse hyperbolic shear deformation theory ihsdt applied finite element formulation effect damage analyzed thin composite plates anisotropic damage formulation used simulate damage based concept stiffness reduction computer programming developed matlab environment excellent agreement results obtained present method references shows technique effective precise parametric studies buckling behavior damaged composite plate presented critical buckling temperatures computed damaged plate using present model thermal post buckling equilibrium paths traced various parametric variations composite plates mild damage compared results undamaged cases validation ihsdt demonstrated buckling analysis thermal environment composite plates internal flaw present work worthwhile compared previous works due choice finite element method inverse hyperbolic shear deformation theory analyzing influence damage buckling post buckling behavior laminated plates institution structural engineers published elsevier ltd rights reserved
although millions cats live among humans worldwide scientific community knows relatively little cat behavior cognition olfaction important perceptual sense many members carnivora however role chemical signals cat social relationships fully understood research indicates chemical signals play important role many areas cat behavior including mother offspring conspecific interactions exploration environment chemical cues appear play role stress anxiety reduction allowing cats feel secure environment better understanding cat chemical signals especially relates within species communication may lead increase cat wellbeing humans utilize knowledge applied settings therefore purpose review investigate cats process use chemical signals social contexts identify ways information applied address cat behavioral issues inappropriate litter box scratching behavior improve cat welfare including species appropriate ways reinforcing human cat bond elsevier rights reserved
objectivesthe aim study examine association levels past current alcohol consumption cause liver related mortality among people living hiv plwh methodsa prospective cohort study plwh baltimore carried ascertained alcohol use self report computer assisted self interview medical record abstraction provider documented alcohol use alcohol consumption categorized heavy men drinks day drinks week women drinks day drinks week moderate alcohol consumption less heavy none calculated cumulative incidence liver related mortality fitted adjusted cause specific regression models account competing risks resultsall cause liver related mortality rates mrs per person years respectively cause mortality highest among nondrinkers recent months ago showed similar rates liver related mortality respectively conclusionsany heavy alcohol consumption associated cause mortality among hiv infected individuals recent heavy consumption associated liver related mortality mortality risk among nondrinkers varies substantially drinking history current consumption alone insufficient assess risk
fibrosis solid organ transplantation considered irreversible process remains major cause graft dysfunction death limited therapies remodeling characterized aberrant accumulation contractile myofibroblasts deposit excessive extracellular matrix ecm increase tissue stiffness studies demonstrate however stiff ecm promotes fibroblast myofibroblast differentiation stimulating ecm production creates positive feedback loop perpetuates fibrosis hypothesized simultaneously targeting myofibroblast contractility relaxin ecm stiffness lysyl oxidase inhibitors could break feedback loop reversing established fibrosis test used orthotopic tracheal transplantation ott mouse model develops robust fibrotic airway remodeling mice established fibrosis treated saline mono combination therapies although monotherapies effect combining agents decreased collagen deposition promoted epithelialization remodeled airways relaxin inhibited myofibroblast differentiation contraction matrix stiffness dependent manner prostaglandin pge furthermore effect combination therapy lost pge receptor knockout pge inhibited ott mice study revealed important synergistic roles cellular contractility tissue stiffness maintenance fibrotic tissue suggests new therapeutic principle fibrosis orthotopic tracheal transplant mouse model targeting two components biophysical microenvironmentnamely myofibroblast contractility extracellular matrix stiffnesscan break autocrine fibrogenic positive feedback loop facilitate self repair attenuate airway fibrosis
artificial intelligence provides rich set methods tools implementing ambient intelligence vision transform environments smart spaces assisting everyday tasks intelligent seamless non obtrusive way among semantic web technologies rdf ontology languages others used address several challenges come vision mainly respect modelling sharing reasoning context information thematic issue demonstrates capabilities presenting three different semantic web based solutions mobile computing environments
trophic ulcer pressure ulcer caused external trauma part body compromised due disease vascular insufficiency loss afferent nerve fibers spinal dysraphism neural tube defects ntd meningomyelocele risk factor developing ulcers adults pediatric patients information regarding occurrence trophic ulcers pediatric patients ntd lacking review english language literature skin neuropathic ulcers patients ntds irrespective study design published undertaken using pubmed database search terms included trophic ulcer neuropathic ulcer ntds meningomyelocele among papers related skin care neonates pediatric patients addressed skin ulcers patients ntd french review article german case report english cohort studies reviewing surgical techniques typically ulcers patients ntd neuropathic related nerve pathology common type meningomyelocele patients ntd present spectrum functional sensory deficits impair mobility causative factors may contribute occurrence ulcers include stress tissue length time stress occurs muscle spasticity infection moisture nutritional status patient awareness ulcer risk preventive measures maintaining foot flexibility careful handling bony prominences kyphosis important ulcer occurs management challenging involves collaboration multiple medical surgical nutrition specialists ulcer develops ntd previously treated surgically mri shows evidence retethering surgical treatment needed research needed help guide ulcer prevention treatment strategies pediatric patients ntd
new classes descriptor fractional continuous time discrete time linear systems regular pencils introduced electrical circuits example descriptor fractional continuous time systems using caputo definition fractional derivative weierstrass regular pencil decomposition laplace transformation solution state equation descriptor fractional linear systems derived shown every electrical circuit descriptor fractional systems contains least one mesh consisting branches ideal supercondensators voltage sources least one node branches containing supercoils using weierstrass regular pencil decomposition solution state equation descriptor fractional discrete time linear systems derived method decomposition descriptor fractional linear systems regular pencils dynamic static parts proposed considerations illustrated numerical examples
purpose secondary analysis test ferrans nurs scholarsh revised model health related quality life hrqol modified wilson cleary med assoc model women living hiv primary aim test model examining relations among five central components biological function symptoms functional status general health perceptions hrqol secondary aim explore individual age children race marital status education environmental hiv related stigma social support characteristics may impact main components model study employed cross sectional correlational design using baseline data women living hiv aids participated one two independent randomized controlled trials designed enhance hiv medication adherence path analysis using structural equation modeling used examine hypothesized multivariate relations proposed revised wilson cleary med assoc model hrqol revised model fit exploratory post hoc modified models path depressive symptoms overall general health adequate model fit women lower depressive symptoms lower hiv related stigma higher social support higher physical functioning higher general health perceptions higher overall hrqol results study potential assist healthcare professionals improving hrqol women living hiv aids
one major ideas design multivariate public key cryptosystem mpkc generate quadratic forms polynomial map extension field fact matsumoto imai scheme hfe patarin mfe wang multi hfe chen constructed way sflash akkar quartz patarin gui petzoldt variants schemes advantage extension field type mpkcs reduce numbers variables equations solved decryption process present paper study security mpkcs whose quadratic forms derived quadratic map extension field propose new attack mpkcs attack recovers partial information secret affine maps polynomial time field odd characteristic partial information recovered attacker find plain text given cipher text solving system quadratic equations extension field whose numbers variables equations system quadratic equations used decryption process
lignin recently attracted much attention due renewable nature focused simple self assembly method fabricating size shape uniform enzymatic hydrolysis lignin ehl nanospheres without chemical modification lignin ehl dissolved tetrahydrofuran different initial concentrations subsequently self assembly adding water magnetic stirring fabricating nanospheres self assembled structure process parameters formation mechanism nanospheres investigated transmission electron microscopy tem scanning electron microscopy sem dynamic light scattering dls fourier transform infrared spectroscopy ftir vis absorption spectra results showed nanospheres formed layer layer self assembly approach inside outside based interactions enabled formation nanospheres size range increasing pre dropping ehl concentration resulted increase average diameter yield nanospheres nanospheres good stability average diameters significant change days chemical structural features nanospheres produced significant change preparation process high preparation temperature brought formation gaps surface nanospheres due effect volatile speed solvent moreover average diameter nanospheres decreased increase stirring rate dropping speed water proposed ehl nanospheres eco friendly cost effective therefore promising candidate biomass based carrier elsevier rights reserved
investigation paper dimensional modified korteweg vries zakharov kuznetsov kdv equation describes nonlinear behaviors ion acoustic waves magnetized plasma cooler ions treated fluid adiabatic pressure hot isothermal electrons described boltzmann distribution hirota method symbolic computation obtain one two three soliton solutions equation graphically study solitons related coefficient cubic nonlinearity amplitude one soliton increases increasing width one soliton keeps unchanged increases two solitons three solitons parallel amplitudes solitons increase increasing widths solitons unchanged shown interactions two solitons among three solitons elastic
use first integral method construct closed exact solutions density dependent fitzhugh nagumo telegraph equation method useful obtaining formal solutions many solutions physically relevant hence carefully determine solutions physically useful problem standard diffusion linear density dependent diffusion obtain physically meaningful exact solutions interestingly case linear density dependence shows strong qualitative agreement standard diffusion case cases wave solutions result initial concentration either dissipates tends finite positive value large time one obtain wave solutions general wave speeds standard diffusion case density dependence diffusion resulting wave speeds take specific values depending values model parameters stronger density dependent diffusion involving quadratic higher order functions concentration show equation integrable exact solutions expected cases
joan torras professor strength materials school architecture barcelona considered beam equal strength structurally extremely efficient beam also beautiful ability reflect material strength torras structures left special mark barcelona work illustrious students rafael guastavino united states published similar structures antoni gaudi josep maria jujol transfigured mimetically barcelona park guell tarragona metropol theatre respectively examples show expressive gesture thoroughly transform technical form artistic form fact inevitably recalls wisdom classical greek mimesis
trabecular bone cortical bone different bone remodeling levels underlying mechanisms fully understood present study expression wnt beta catenin signaling downstream molecules along bone mass trabecular cortical bone compared wild type mice constitutive activation beta catenin beta catenin mice beta catenin deletion mice found expression level examined genes wnta beta catenin osteocalcin rankl opg ratio significantly higher trabecular bone cortical bone wild type mice beta catenin resulted regulated expression mentioned genes except rankl opg ratio regulated also beta catenin led increased number osteoblasts decreased number osteoclasts increased bone mass trabecular bone cortical bone compared wild type mice however extent changes much greater trabecular bone cortical bone contrast null beta catenin led regulated expression mentioned genes except rankl opg ratio furthermore beta catenin deletion led decreased number osteoblasts increased number osteoclasts decreased bone mass compared wild type mice extent changes significant trabecular bone cortical bone taken together found expression level wnt beta catenin signaling bone remodeling related molecules different cortical bone trabecular bone trabecular bone readily affected changes wnt catenin signaling pathway orthopaedic research society
detecting surface coal mining areas scmas using remote sensing data timely accurate manner necessary coal industry management environmental assessment developed approach effectively extract scmas remote sensing imagery based object oriented decision trees oodt oodt approach involves three main steps object oriented segmentation calculation spectral characteristics extraction scmas advantage approach lies effective integration spectral spatial characteristics scmas distinguish mining areas extracting areas stripped areas dumping areas areas exhibit similar spectral features bare soils built areas implemented method extract scmas eastern part ordos city inner mongolia china results overall accuracy kappa coefficient compared three spectral information based methods oodt approach accurate quantifying amount spatial pattern scmas dryland regions society photo optical instrumentation engineers spie
aim delineate sleep profile borderline personality disorder bpd method meta analysis synthesise findings objective subjective sleep characteristics bpd results identified studies published december meta analysis indicated significant differences bpd healthy control groups across objective sleep continuity sleep onset latency total sleep time sleep efficiency architecture rapid eye movement latency density slow wave sleep measures self reported sleep problems nightmares sleep quality findings independent depression clinical community populations concomitant psychotropic medication use significant differences bpd clinical majority depressed control groups conclusion bpd associated comparable sleep disturbances observed depression disturbances solely attributable comorbid depression given growing evidence sleep disturbance may exacerbate emotional dysregulation suicide risk treatments bpd explicitly address sleep problems future studies utilise prospective designs ascertain whether circumstances sleep problems predate follow onset disorder elsevier ltd rights reserved
face perception models propose different facial attributes processed anatomically distinct neural pathways partially overlap whether attributes interact functionally open question goal determine interactions age ethnicity processing temporal epoch interactions evident monitored event related potentials electroencephalography subjects categorized faces age ethnicity two conditions baseline two properties categorized held constant interference condition also varied modelled garner interference paradigm found participants categorizing faces age variations ethnicity increased amplitude right face selective component subjects categorizing faces ethnicity variations age alter concluded asymmetric pattern influence age ethnicity early face specific stages visual processing parallels behavioural evidence asymmetric interactions identity expression processing faces
background aims biosimilar version infliximab remsima recently entered european market clinical data use inflammatory bowel disease ibd sparse especially switching originator remicade study aimed prospectively investigate feasibility safety immunogenicity switching remicade remsima real life ibd population methods adult patients treated remicade department gastroenterology oslo university hospital switched remsima follow lasted months addition retrospective registration performed start time months switching drugs primary endpoints proportion patients remaining medication months switching adverse events months switching secondary endpoints included disease activity scores harvey bradshaw index partial mayo score reactive protein haemoglobin faecal calprotectin infliximab dose interval infliximab development antidrug antibodies results total ibd patients switched crohn disease ulcerative colitis large majority remained medication throughout follow low number adverse events observed change disease activity reactive protein haemoglobin faecal calprotectin infliximab dose interval infliximab detected three patients developed new detectable antidrug antibodies conclusions switching remicade remsima feasible adverse events including limited antidrug antibody formation loss response
present quantum key distribution qkd method allows demonstrate practical quantum cryptography used obtaining cryptographic key encode information communicated legitimate parties generally relates secured key sharing method system plurality transmitters plurality receivers particularly system method qkd transmitters receivers aspect method qkd system capable forming first signals different phases polarization second signals different delay time transmitter sends two signals share key receiver first signal generated different phases polarization protect transmission channel reference time second signal state first signal delay time first signal second signal key method leads increase length shared key method used implement practical qkd system used switching protocol protocol optical fiber one way system free space setups unconditionally security secure keys generated qkd network managed key management layer key management agents kmas used encrypt data send receivers proposed schemes aimed provide secure end end communication
high effort involved airborne synthetic aperture radar sar systems led effect sar image processing mostly restricted single images scene recent developments like miranda matching flight platform allow frequent revisits scene high repeatability miranda designed lightweight compact sar sensor altitudes providing resolution combination highly flexible ultralight aircraft recently obtained measurements scene within flight time high repeatability two sets flight courses flyovers reference scene modified change scene investigated using statistical change detection methods like informational difference universal image quality index
study novel second order universal filter using current feedback amplifier commercially available active component presented signal flow graph method used synthesize filter proposed filter three high impedance input one output multiple input single output miso configuration generate biquadratic filtering functions namely low pass band pass high pass band reject pass output terminal selecting different input signal combinations validity proposed circuits demonstrated simulations elsevier gmbh rights reserved
background non hereditary angioedema non hae characterized local swelling due self limiting subcutaneous submucosal extravasation fluid divided three subtypes subtypes believed different pathophysiological backgrounds referred recent guidelines bradykinin mediated caused angiotensin converting enzyme inhibitors mast cell mediated angioedema wheals idiopathic cause unknown bradykinin mediated subtypes closely related hereditary angioedema forms clinical features non hae subtypes studied detail looked clinical characteristics symptoms potential differences clinical presentation bradykinin mediated mast cellmediated angioedema subtypes methods questionnaire sent patients presenting tertiary outpatient clinic document clinical characteristics potential triggers location severity attacks analysed using visual analogue scales vas results questionnaire returned patients included analysis wheals idiopathic drug associated occurred patients respectively patients reported prodromal symptoms reported multiple locations attack face oropharynx main locations attacks subtype swelling symptom frequently reported severe overall severity last attack indicated severe patients differences subgroups conclusion similarity clinical presentation raises possibility acei induced mast cell mediated idiopathic share common pathways
objective prospective study designs ideally allow patients followed first manifestations illness even risk stage thus provide data predictive value changes clinical symptomatology cognition biological markers broaden understanding etiopathology symptomatic trajectory bipolar disorders scope narrative review summarize evidence prospectively collected data psychopathological clinical biological changes early developmental course bipolar disorders methods narrative review based literature search conducted february within pubmed library prospective study data persons antecedent early manifest stages manifest bipolar disorder published within last years results total prospective studies included regarding psychopathological features personality temperament character traits well changes sleep circadian rhythm evidence suggests risk factors development bipolar disorder already described studied understand interaction mediation factors timing developmental process bipolar disorder apart positive family history childhood anxiety sleep problems subthreshold hypo manic symptoms certain character traits emotionality identified monitored already clinical practice presence likely increases risk bipolar disorder date substantiated evidence found prospective studies addressing cognitive features life events immunological parameters morphological central nervous system changes potential risk factors bipolar disorder conclusion improved understanding episodic disorders longitudinal data collection essential since etiology bipolar disorders complex number potential risk factors proposed prospective studies addressing spectrum resilience factors critical best conducted within multi site research networks initiatives
objectives negative effect changes social behavior following traumatic brain injury tbi known much less known neuropsychological impairments may underlie predict changes current study investigated possible associations post injury behavior neuropsychological competencies emotion recognition understanding intentions response selection proposed important social functioning methods forty participants tbi matched healthy participants completed battery tests assessing three functions interest addition self proxy reports pre post injury behavior mood community integration collected results tbi group performed significantly poorer comparison group tasks emotion recognition understanding intention one task response selection ratings current behavior suggested significant changes tbi group relative injury showed significantly poorer community integration interpersonal behavior comparison group three functions considered emotion recognition associated post injury behavior community integration association could fully explained injury severity time since injury education conclusions current study confirmed earlier findings associations emotion recognition post tbi behavior providing partial evidence models proposing emotion recognition one pre requisites adequate social functioning
efficiently simulating light transport various scenes single algorithm difficult important problem computer graphics two major issues shown hinder efficiency existing solutions light transport due multiple highly glossy specular interactions scenes complex visibility camera light sources recent bidirectional path sampling methods vertex connection merging unified path sampling vcm ups efficiently deal highly glossy specular transport tend perform poorly scenes complex visibility hand markov chain monte carlo mcmc methods able show excellent results scenes complex visibility behave unpredictably scenes glossy specular surfaces due fundamental issue sample correlation paper show fuse underlying key ideas behind vcm ups mcmc single efficient light transport solution algorithm specifically designed retain advantages approaches alleviating limitations experiments show algorithm efficiently render scenes highly glossy specular materials complex visibility without compromising performance simpler cases
progesterone prog naturally occurring progestagen used prevent preterm birth control persistent anovulatory bleeding treat premenstrual syndrome clinical practices studies metabolism prog demonstrated prog precursor steroids beta pregnane alpha alpha diol testosterone hydroxyprogesterone commonly used endogenous reference compound erc isotope ratio mass spectrometry irms analysis doping control expected prog administration could affect carbon isotope ratios expressed delta value metabolites lead false negative false positive results doping test influences oral intramuscular administration prog urinary steroid profile carbon isotope ratios steroids investigated study demonstrated urine concentrations delta values affected obviously depleted delta values could used suggest prog administration using erc may result distorted evaluation suspicious urine sample irms analysis prog ingested alpha androst alpha beta hydroxyandrosterone could used alternative ercs case prog administration carbon isotope ratios androsterone etiocholanolone etio two metabolites remained unchanged throughout excretion study suggested delta values etio could still used urinary markers administration even prog administrated
objectives changes estrogen receptor expression likely underlie differential metabolic effects estrogen pre postmenopausal women aim current study determine whether gene expression abdominal femoral subcutaneous adipose tissue sat associated age menopause regional adiposity methods studied pre post menopausal respectively age normal weight mean bmi women similar total fat mass abdominal femoral sat alpha esr beta esr mrna expression determined qpcr results total fat mass differ pre postmenopausal women compared premenopausal women esr ratio esr esr lower postmenopausal abdominal femoral sat esr esr esr inversely associated age abdominal sat respectively femoral sat respectively esr related age menopause inverse association esr age persisted adjusting trunk fat mass estradiol leptin conclusion among healthy pre postmenopausal women increased age associated decreased balance era beta abdominal femoral subcutaneous adipose tissue elsevier inc rights reserved
leadership operations center loc responsible facilitating coordinating implementing antibacterial resistance leadership group arlg scientific agenda engaging thought leaders soliciting research proposals developing processes tools infrastructure required operationalize studies create sustain arlg network efforts ongoing new projects developed network expands grows address ever changing priorities antibacterial resistance article describes innovations accomplishments opportunities loc since inception arlg
absolute erythrocytosis present red cell mass greater predicted value sex body mass primary secondary congenital acquired cause new causes particularly congenital continue discovered investigated investigation cause starts repeat confirmation raised hemoglobin measurement erythropoietin level indicate whether pursue primary secondary causes investigations appropriate management options include low dose aspirin venesection specific management advice available certain specific clinical situations
purpose pituitary abscess rare commonly described case reports small case series study aimed better determine salient clinical manifestations related diagnosis appropriate treatment using far largest case series disease methods total consecutive patients underwent surgery pituitary diseases peking union medical college hospital january december among cohort sixty six patients diagnosed based intraoperative findings postoperative histopathological evidence results common clinical presentation anterior pituitary hypofunction followed common headache diabetes insipidus visual disturbances symptoms related infection forty patients showed typical rim enhancement gadolinium injection magnetic resonance imaging mri patients underwent transsphenoidal surgery tss remaining patients treated transcranial surgery follow years diminished patients demonstrated post operative mri eight patients underwent least one additional operation due recurrence conclusions patients hypopituitarism rim enhancement mri consider possible diagnosis proper use antibiotics complete drainage via surgery hormone replacement hypopituitarism key treatments
objective studies evaluated effects visual remediation strategies schizophrenia despite abundant evidence visual processing alterations condition report preliminary case study based evidence regarding effects visual remediation population method describe implementation visual perceptual training program called ultimeyes initial results brief case studies individuals schizophrenia targets broad based visual function including low level processes acuity contrast sensitivity well higher level visual functions three inpatients recruited research unit participated least sessions times per week approximately min per session contrast sensitivity trained task well acuity perceptual organization untrained tasks assessed intervention levels progression task also reported results well tolerated participants led improvements contrast sensitivity well generalized gains visual acuity participants perceptual organization participants symptom profiles somewhat different participant symptomatic intervention despite able focus benefit training adaptive nature training well suited slower progression participants conclusions implications practice case studies set stage research larger randomized controlled trials intervention include additional assessments perceptual function measures cognition social cognition functional outcomes
notwithstanding recent advances cognitive impairments among difficult treat symptoms neuropsychiatric disorders deficits information processing contributing memory sociability impairments found across neuropsychiatric related disorders previously shown mutations dtnbp gene encoding dystrobrevin binding protein dysbindin lead abnormalities synaptic glutamate release prefrontal cortex pfc hippocampus cognitive deficits glutamatergic transmission important cortical recurrent excitation allows information processing pfc investigate possible means restoring glutamate release improving cognitive impairments assess effects increasing endogenous levels brain derived neurotrophic factor bdnf dysbindin deficient mouse model increasing endogenous levels bdnf may aid remediating cognitive deficits given roles bdnf synaptic transmission plasticity neuroprotection increase bdnf use novel strategy repeated intraperitoneal injections fingolimod gilenya sphingolipids recently shown therapeutic value several neurology related disorders wild type mutant mut genotypes tested sociability recognition memory followed measuring endogenous bdnf levels presynaptic within pfc genotypes treated week either saline fingolimod relative mice mut mice demonstrated impairments sociability recognition memory lower presynaptic calcium fingolimod treatment mut mice exhibited significant improvements sociability recognition memory increases presynaptic calcium endogenous concentrations bdnf results show promise counteracting cognitive impairments seen neuropsychiatric disorders may shed light role dysbindin wiley periodicals inc
paper presents novel concept virtual metrology frame enhancing dynamic performance machine tool flexible structural frame dynamic properties machine directly affected stiffness frame reference system thus unstressed metrology frame superior dynamic capabilities achieved developed concept require physical components associated metrology frame hence ideal machine tools requirements small footprint ultra precision performance concept relies accelerometer based dynamic displacement feedback technique accelerometer used precision frame displacement sensor concept require complex controller realized shelf cnc controller concept demonstrated linear motion system simplified version compact size cnc machine servo bandwidth dynamic stiffness improved respectively key parameters improving machining accuracy authors published elsevier inc
flexible snake robot better navigation ability compare existing electrical motor based rigid snake robot due excellent bending capability navigation inside narrow maze paper discusses modelling simulation experiment flexible snake robot modelling consists kinematic analysis dynamic analysis snake robot platform based incompletely restrained positioning mechanism irpm proposed uses external force provided compliant flexible beam actuators compliant central column allows configuration achieve three degrees freedom dofs three tendons proposed flexible snake robot built using smart material electroactive polymers eaps activated applying power finally physical prototype snake robot built experiment performed order justify proposed model
nerve growth factor ngf plays crucial roles promoting neural growth survival mediating synaptic morphological plasticity several studies investigated correlation peripheral ngf levels major psychiatric disorders including schizophrenia scz major depressive disorder mdd bipolar disorder bpd however findings inconsistent meta analysis sought investigate blood ngf levels patients psychiatric disorders compared healthy subjects examined potential effects blood fraction medication disease status total eligible studies encompassing patients suffering psychiatric disorders healthy subjects enrolled present meta analysis obvious publication bias observed either scz mdd bpd begg test random effects meta analysis showed scz smd mdd smd patients significantly reduced ngf levels compared healthy controls notably decrease enhanced medicated patients scz medicated chronic patients mdd results supported association reduction ngf levels psychiatric disorders remains unclear whether change ngf levels prerequisite function psychiatric disorders development merely epiphenomenon unrelated pathophysiologic mechanisms elsevier ltd rights reserved
goal study address preliminary design prototyping novel phase segment type switched reluctance motor seg srm pole configuration proposed seg srm includes stator salient poles rotor segmental steel cores embedded aluminum block operation seg srm depends exciting two adjacent phases respectively times creating mutual coupling thus leading less eddy current effects silicon steel sheets stator better efficiency quick design methodology covering geometrical details segsrm given comprehensive method useful initial machine design eliminates machines undesired outputs besides performance characteristics designed seg srm investigated finite element method fem finally prototype manufactured tested laboratory based computed analytical parameters operational outcomes developed system presented verifying finite element studies completely substantiated new preliminary design used applications ranging low speed medium speed comparative study among simulation experimental studies seeks address torque production prediction versus current variation
computer programming challenge students major reason people avoid computer science courses investigating alternative teaching methods essential encourage students learn understand concepts programming use games learning training advocated supported many researchers due motivational attractive features study focuses approach supports use learning methodologies based constructionist activities therefore pedagogical framework proposed guide lecturers teach programming integrate games based learning present coding concepts context familiar real world applications like computer games development framework supported motivational attractive game features conjunction authentic meaningful aspects constructionist activities games based construction learning gbcl paper summarises presents framework model based literature review panel experts view performing two stage process validate framework paper discusses design validation framework proposes actions regarding implementation
objective varenicline vcl treatment become popular part smoking cessation therapies even though possible implications neuropsychiatric adverse events include abnormal sleep nightmares study first aimed prospectively investigating changes sleep dream measures across treatment using one week sleep diary collecting dream recall methods thirty eight smokers participated two different effective smoking cessation programs subjects received vcl subjects received nicotine replacement therapy nrt participants requested fill sleep diary audio record dreams one week baseline assessment two weeks beginning treatment differences sleep dream measures tested using mixed analysis covariance time within subject factor group vcl nrt subject factor considering age covariant results sleep measures showed significant increase number awakenings vcl group compared vcl group reported increase rate sleep dream measures intercorrelated vcl treatment conclusions correlations rate sleep fragmentation measures underlined vcl considered direct cause abnormal dreams comparisons groups cast doubts actual existence abnormal dreams least compared nrt group results consistent activation models showing numerous drs vcl group may related lighter sleep elsevier rights reserved
cognitive biases may play significant role disorders decision making pathological gambling addiction understanding neurobiology biases could lead effective pharmacological therapeutic treatments disorders aberrant decision making prominent rodent betting task rbt designed measure one commonly observed decision making heuristic rodents namely escalation commitment subjects become risk averse stakes increase even odds success remain constant rodent task animal presented choice two options equivalent expected value reward one option guaranteed chance double prize nothing past work shown subset animals termed wager sensitive adopt irrationally risk averse choice preference shift choice away uncertain option bet size grows larger current study orbitofrontal ofc prelimbic prl infralimbic cortex inactivated evaluate contributions made regions choice behavior rbt inactivation ofc prl selectively ameliorated risk averse choice pattern characteristic wager sensitive animals finding suggests ofc may relatively unique role promoting type non normative decision making uncertainty effect potentially related role representing subjective value reinforcing outcomes article part special issue entitled cognitive flexibility published elsevier ltd behalf ibro
taking cable stayed suspension hybrid bridge main span example seismic response bridge horizontal vertical seismic excitations investigated numerically response spectrum analysis time history analysis seismic performance discussed compared cable stayed bridge suspension bridge main span considering aspect seismic performance feasibility using cable stayed suspension hybrid bridge super long span bridges discussed horizontal seismic action effects structural design parameters including cable sag span ratio suspension span ratio side span length subsidiary piers side spans girder supporting system deck form etc seismic performance bridge investigated response spectrum analysis favorable values design parameters proposed
consider fuzzy controller design problem boost converter design fuzzy type controller based common control engineering knowledge transient control performance improved increase gains error grows using kharitonov theorem derive closed loop control system stability condition used tune fuzzy control parameters finally give simulation experimental results show effectiveness practicality proposed method
objective dactylitis long recognised one significant features spondyloarthropathies literature prevalence dactylitis enteropathic spondyloarthritis easpa ranges aim study identify prevalence dactylitis easpa patients investigate association clinical subset articular bowel disease activity methods easpa patients controls enrolled study patients controls underwent rheumatological gastroenterological clinical examination demographic clinical features recorded diagnosis dactylitis made physical examination evaluated using leeds dactylitis instrument ldi results study prevalence dactylitis easpa mainly patients crohn disease peripheral arthritis significantly higher articular bowel disease activity found patients dactylitis compared without family history psoriasis represented predictor occurrence dactylitis finally significant correlation disease activity ldi score found easpa conclusion results study showed high prevalence dactylitis easpa frequent patients peripheral involvement higher articular disease activity confirming dactylitis may severity marker prognostic factor easpa significant correlation disease activity ldi score could address ldi potential tool assessment dactylitis
strain rate significantly affect strength materials split hopkinson pressure bar shpb initially utilized study effects high strain rate approximate behavior metals subsequent modifications original technique allowed study brittle materials ceramics concrete rock although material properties wood static creep strain rates readily available data dynamic properties wood limited previous work using shpb technique wood considered conditions tests prove applicability shpb wood performed study tests conducted using large diameter shpb hard maple specimens consisting sugar maple acer saccharum black maple acer nigrum eastern white pine pinus strobus specimens utilized represent dense hardwood low density soft wood specimens machined diameters assortment lengths tested determine appropriate specimen dimensions stress strain curves generated shpb data validated aluminum wood specimens stress indirectly corroborated gauged aluminum specimens specimen strain assessed strain gauges digital image analysis measurement residual strain confirm strain calculated shpb data shpb found useful tool assessing material properties wood subjected compression high strain rates short load durations specimens loaded longitudinal direction length specimens loaded radial tangential directions length found applicable shpb testing data resulting study show short duration region madison curve reasonable high strain rate compression wood range specific gravities considered
objectives compare standard sequential planning method offline planning method based contrast enhanced magnetic resonance angiography mra children congenital heart disease chd design children complex chd mean years range months years axial coronal cuts obtained single slice spin echo sequences get final double oblique longitudinal cut targeted anatomical structure separate workstation similar maximal intensity projection mip images generated offline mra mip images localizers repeated targeted imaging using previous spin echo sequence finally image coverage spatial orientation acquisition time compared main outcome measures images similar perfectly covered selected anatomic regions spatial differences found mean time creation final imaging plane compared conclusions shows similar results compared allows faster offline planning thereby reducing scan time significantly newly developed high resolution datasets also used improvement technology expected
objective review findings clinical relevance add knowledge antisocial aggressive behaviour among persons schizophrenia method nonsystematic literature review results recent evidence shows individuals develop schizophrenia present cognitive deficits psychotic like experiences internalizing externalizing problems childhood onwards many relatives present schizophrenia related disorders also antisocial behaviour increased risk aggressive behaviour among persons schizophrenia robustly established recent findings show first contact clinical services psychosis people schizophrenia engage aggressive behaviour may identified first episode distinct types distinguishable present history antisocial aggressive behaviour since childhood began engaging aggressive behaviour illness onsets antipsychotic medications treatments shown effective schizophrenia needed types patients additionally history antisocial aggressive behaviour since childhood require cognitive behavioural programs aimed reducing behaviours promoting prosocial behaviour reducing physical victimisation cannabis use likely reduce aggressive behaviour evidence suggests threats hurt others often precede assaults conclusions first contact services patients schizophrenia engaged aggressive behaviour identified treated schizophrenia aggression research needed identify interactions genotypes environmental factors conception onwards promote protect development aggressive behaviour among persons schizophrenia
discrete time signal processing receivers combine gain conversion anti aliasing sampling filtering offset compensation one analog block reduce size solution paper presents analog front end afe single chip gsm gprs edge gge radio digital cmos based discrete time analog signal processing heart afe passive switched capacitor stages providing gain boosting impedance transformation providing order filter response afe achieves dbm iip filter occupies boolean consumes
paper consider nested decomposition method context multistage stochastic problems scenario trees contribute improvements accelerating convergence optimum first propose hybrid protocol transmitting cuts across nodes aiming trade inherent benefits drawbacks single aggregated versus multi cut desegregated versions idea aim explore reduce size problem solved iteration applying aggregated version cuts furthest nodes tree turn attention towards selection first stage solutions employing sampling simulation aiming carefully choose first stage solution potentially capable drastically decrease gap upper lower bound iteration problems latter technique applied present special structure according first stage variables linked stages test accelerating techniques generic problem displays blend two stage multistage structure report significant savings terms cpu time number iterations convergence
prior research supported mere presence hypothesis suggests cell phones act environmental nuisance negatively impact quality face face interactions study conducted experiment determine whether cell phone presence negatively influences conversation satisfaction specifically network member dyads engaged unstructured conversations one partner cell phone either absent present results revealed whereas mere presence cell phone influence conversation satisfaction individuals recollection whether cell phone present significantly negatively impact pre posttest reports conversation satisfaction implications findings research mere presence hypothesis well directions future research discussed
severe plastic deformation enables obtaining materials characterized ultrafine grained ufg structure nanostructure high grain refinement increases strength materials according hall petch relation case ufg materials high ductility materials also reported accumulative roll bonding arb method process consecutive reduction equal two sheets pack rolling pass satisfies condition severe plastic deformation enables obtaining theoretically unlimited high plastic deformation paper changes mechanical properties rnicrostructure alloy processed pass passes according arb procedure reported optimal processing conditions proposed obtain maximum strength accompanied maximum plasticity
four bench scale solar photocatalytic reactors fabricated viz solar photocatalytic single baffle reactor spsbr solar photocatalytic multiple baffles reactor spmbr solar photocatalytic cascade reactor spcr solar photocatalytic pond reactor sppr capacity evaluation reactors performance carried varying volume wastewaters range recycle flow rates range min degradation phenolic wastewaters single baffle reactor gives maximum phenol removal efficiency irrespective volume wastewater phenol removal efficiency increases recycle flow rate increased min decreased recycle flow rate min single baffle reactor showed maximum phenol removal efficiency recycle flow rate min untreated pulp paper mill wastewater phenol concentration bod cod ratio solar photocatalytic treatment enhanced biodegradability values
janus kinases jaks gain function mutants implicated range oncological inflammatory autoimmune conditions sparked great research interest discovery development small molecule jak inhibitors two molecules currently marketed jak inhibitors due displayed side effects owing suboptimal selectivities among various jak subtypes new jak inhibitors still sought present results extensive virtual screening campaign based multi step screening protocol involving ligand docking screening yielded five new experimentally validated inhibitors jak hydroxyquinoline novel hinge binding scaffold compounds display favorable potencies jak driven cell based assay also shown non cytotoxic rat liver cells
problem renin angiotensin system associated angiogenesis tissue remodeling prenatal development cytokine production purpose study evaluate whether polymorphisms angiotensin converting enzyme ace insertion deletion angiotensinogen agt angiotensin type receptor atr affect prevalence spontaneously aborted fetuses safs method study one hundred ninety eight safs werec genotypes results ace agt atr significantly different controls particular statistical significance genotype remained strong chromosomally normal safs conclusion data suggest ace agt atr possible predisposing factor spontaneous abortion
relationships biological rhythms affective disorders known underlying biology clear difficulty studying circadian rhythms humans appropriate animal models hard identify develop studies show diurnal rodents advantageous model animals study interactions biological rhythms affective disorders previous studies include females whereas humans sex differences affective disorders present study tested effects short photoperiods males females diurnal golden spiny mouse acomys russatus adult female male spiny mice housed either neutral photoperiod light dark short photoperiod light dark conditions weeks acclimatization animals tested spontaneous activity open field elevated plus maze epm sweet solution preference ssp forced swim test fst sexes responded males showed increased anxiety like behavior epm depression like behavior fst females showed increased activity reduced anxiety like behavior epm depression like response ssp effect fst differences sexes previously demonstrated behavioral tests followed variety manipulations usually explained context sex hormones yet current results compared previous data diurnal rodents testing females diurnal rodents needed explore whether differences general phenomenon possibly unique golden spiny mice elsevier inc rights reserved
split hopkinson bar used study dynamic mechanical properties fine grained aluminium rich composite materials obtained hot pressing sintering true stress strain curves acquired different strain rates compared properties quasi static situation results reveal strength materials improves plasticity decreases increase strain rate yield strength elastic modulus strain rate times respectively higher quasi static situation fracture morphology analyzed indicated fracture mode consists cleavage fracture intergranular fracture dimple fracture according experimental data modified dimensional elastic brittle constitutive model damage built obtained constitutive equation fracture failure specimens relationship parameters strain rate modified constitutive model presented fit experimental data well
objective higher plasma soluble cluster differentiation scd shed monocytes macrophages correlates neurocognitive impairment hiv infection hypothesized higher antemortem plasma cerebrospinal fluid csf scd would associated greater postmortem neurodegeneration microgliosis design retrospective postmortem observational study methods measured scd levels antemortem plasma csf samples hiv seropositive participants median months death donated brains research autopsy postmortem quantified markers synaptodendritic damage microtubule associated protein synaptophysin microgliosis human leukocyte antigen hla ionized calcium binding adaptor molecule astrocytosis glial fibrillary acidic protein impaired protein clearance amyloid frontal cortex hippocampus putamen internal capsule multivariable least squares regression used evaluate association plasma csf scd histological measures correcting multiple comparisons results higher plasma scd associated lower microtubule associated protein frontal cortex confidence interval putamen hippocampus lower synaptophysin hippocampus putamen frontal cortex higher plasma scd associated higher hla putamen csf scd associated histological measure conclusion higher plasma scd life associated greater synaptodendritic damage microglial activation cortical subcortical brain regions copyright wolters kluwer health inc rights reserved
neural synchrony basal ganglia especially beta frequency band hallmark parkinson disease considered antikinetic contrast healthy basal ganglia show low levels synchrony currently unknown synchrony oscillations arise parkinsonian brain transmitted basal ganglia well makes dependent dopamine external part globus pallidus recently identified hub nucleus basal ganglia possessing intrinsic inhibitory connections possibly also gap junctions study show conductance based network model basal ganglia combination sparse high conductance inhibitory synapses sparse low conductance gap junctions external part globus pallidus could effectively desynchronize whole network however gap junction coupling became strong enough effect impeded activity synchronized particular sustained periods beta coherence occurred neuron pairs gap junctions change conductance dopamine level suggest pallidal gap junction coupling mechanism contributing development beta synchrony parkinsonian basal ganglia
structured trauma focused cognitive behavioral therapy cbt techniques widely considered effective intervention children experienced sexual abuse however unstructured nondirective play experiential techniques longer history widespread promotion preferred many practicing clinicians evidence available however determine integration techniques impacts treatment outcome study community based clinicians received training structured trauma focused cognitive behavioral intervention administered pretreatment posttreatment evaluations sexually abused children presenting elevated posttraumatic stress addition completed questionnaire describing treatment techniques implemented child overall significant improvement observed six clinical outcomes regression analyses indicated technique selection significant factor posttreatment outcome posttraumatic stress dissociation anxiety anger aggression general greater utilization structured cbt techniques related lower posttreatment scores whereas higher frequency play experiential techniques associated higher posttreatment scores however interaction effects observed implication findings clinical practice future research examined
mobile networks promising offer mobile users unrivaled experiences infinite networking capability period anywhere however appears unnecessary impractical customers servers connected permanently wireless networks battery life bottleneck kind networks therefore authorized entity needs delegate right others order ensure services available paper aims address issue delegating authentication networks proposing new proxy signature scheme efficient proxy signing operations concretely present new efficient proxy signature algorithm whose unforgeability reduced well known discrete logarithm assumption proposal original signer delegates signing right signing exposure free chameleon hash value warrant proxy signer generate proxy signature message calculating chameleon hash collision warrant message approach computationally cost effective proxy signer analysis new scheme demonstrates offers desirable properties delegation signing sights copyright john wiley sons ltd
massive forests central amazonia often considered relatively resilient climatic variation view challenged wildfires invoked recent droughts impact fires spread pervasive sources ignition may reveal forests less likely persist drier future combine field observations remotely sensed information whole amazon show annually inundated lowland forests run heart system may trapped relatively easily fire dominated savanna state lower forest resilience floodplains suggested patterns tree cover distribution across basin supported field remote sensing studies showing floodplain fires stronger longer lasting impact forest structure well soil fertility although floodplains cover amazon basin fires substantial cascading effects forests peatlands may release large amounts carbon wildfires spread adjacent uplands floodplains thus achilles heel amazon system comes risk large scale climate driven transitions
way data structures organize data often function sequence past operations organization data referred data structure state sequence past operations constitutes data structure history data structure state therefore used oracle derive information history history sensitive applications privacy voting imperative conceal historical information contained within data structure states data structure history hidden making data structures history independent paper explore achieve history independence observe current notions significantly limited number scope two existing notions weak whi strong shi whi protect insider adversaries shi mandates canonical representations resulting inefficiency postulate need broad encompassing notion capture whi shi broad spectrum new notions end introduce delta generic game based framework malleable enough accommodate existing new notions essential step toward formalizing delta explore concepts abstract data types data structures machine models memory representations finally bridge gap theory practice outline general recipe building end end history independent systems demonstrate use recipe designing two history independent file systems
constellation observing system meteorology ionosphere climate cosmic six satellite radio occultation mission launched april close proximity satellites months launch provides unique opportunity evaluate precision global positioning system gps radio occultation retrievals ionospheric electron density nearly collocated simultaneous observations data consecutive days july august divided ten groups terms daytime nighttime latitude cases best precision values found peak height slightly degrade upwards daytime groups seen electron density profiles height exhibit substantial improvement precision nighttime groups rather diverse particular precision becomes better different levels height overall results show depending group uncertainty associated precision order measured electron density values even worse retrieved values tend sometimes negative although rely directly electron density values altitudes shape profiles could indicative ionospheric features waves sporadic layers profiles precision qualitatively quite independent daytime latitude nearly collocated pairs studied exhibited difference line sight angles peak height larger degrees analyzing find clear indications significant representativeness error electron density profiles due spherical assumption height differences precision setting rising gps may attributed modification processing algorithms applied rising cases initial period cosmic mission cospar published elsevier ltd rights reserved
background increasing recognition epidemics primarily tubular interstitial chronic kidney disease ckd clustering agricultural communities low middle income countries lmics although currently unclear whether unified underlying aetiology conditions collectively termed ckd undetermined cause ckdu ckdu estimated led premature deaths tens hundreds thousands young men women last decades thus urgent need understand aetiology pathophysiology condition international comparisons provided first steps understanding many chronic diseases comparisons rely availability standardised tools estimate disease prevalence particular problem ckd since disease asymptomatic late stages biases inherent methods used estimate glomerular filtration rate gfr population studies highly variable across populations method therefore propose simple standardised protocol estimate distribution gfr lmic populations disadvantaged populations egfr epidemiology degree study involves quantification renal function representative adult population based sample requirement standardisation serum creatinine measurements along storage samples future measurements cystatin ascertainment estimates body composition order obtain valid comparisons estimated gfr egfr within populations discussion methodology present potentially applicable anywhere particular focus disadvantaged populations lmics since appear susceptible ckdu although protocol could also used specific groups occupational groups thought excess risk ckdu primary aim degree project characterise population distribution egfr multiple regions international comparisons performed standardised approach possible estimate scale variation impaired kidney function affected areas data provide insights important social demographic environmental risk factors increasingly recognised disease
previous studies investigating entrainment person perception synchronized movements found enhance memory incidental person attributes although effect robust including dance process actuated less well understood study two hypotheses investigated enhanced memory person attributes result increased gaze time tempo dancers greater attentional focus tempo dancers explore possible mechanisms context observing dance eye tracking study conducted subjects watched videos pairs laterally positioned dancers one dancers synchronized music asynchronous results consistent first hypothesis music dance synchrony gives rise increased visual inspection times addition preference upper body fixations lower body fixations across synchronous asynchronous conditions subsequent single dancer eye tracking study investigated fixations across different body regions including head torso legs feet significantly greater dwell times recorded head torso legs feet attracted significantly less dwell time body region lastly study sought identify dance gestures responsible torso head directed fixations specifically asked whether features dance specially designed direct observer gaze towards face main communicative portal respect transmission intent affect empathy
prevalence social media internet opinion mining become essential approach analyzing many data various applications appear wide range industrial domains meanwhile opinions diverse expressions bring along research challenges practical demands research challenges make opinion mining active research area recent years paper present review natural language processing nlp techniques opinion mining first introduce general nlp techniques required text preprocessing second investigate approaches opinion mining different levels situations introduce comparative opinion mining deep learning approaches opinion mining opinion summarization advanced topics introduced later finally discuss challenges open problems related opinion mining elsevier rights reserved
smart material electrohydrostatic actuator based giant magnetostrictive transducer meet requirements smaller vehicles like unmanned combat air vehicle well rotating environments like helicopter rotors order analyze improve performance smart material electrohydrostatic actuator dynamic hysteresis nonlinear model giant magnetostrictive transducer developed based relationship complex permeability magnetic energy power loss giant magnetostrictive material inverse model also derived design inverse compensator improving linearity giant magnetostrictive transducer experiments show help inverse compensator phase lag input control signal output displacement giant magnetostrictive transducer decreased addition simulation results show effect inverse compensator flow rate increased growth rate increases increase excitation frequency
background cognitive deficits predictors functional outcome patients psychosis conventional anti psychotics relatively effective positive symptoms impact negative cognitive symptoms limited recent studies established link oxidative stress neurocognitive deficits psychosis acetylcysteine nac glutathione precursor glutamatergic properties shown efficacy negative symptoms functioning patients schizophrenia bipolar disorder respectively however evidence based approaches managing cognitive impairment psychosis present study aims examine cognitive effects adjunctive nac treatment pooled subgroup participants psychosis completed neuropsychological assessment two trials schizophrenia bipolar disorder method sample participants randomized double fashion receive day nac placebo weeks attention working memory executive function domains assessed differences cognitive performance baseline end point examined using wilcoxon test mann whitney test used examine differences nac placebo groups end point results participants treated nac significantly higher working memory performance week compared placebo conclusions nac may impact cognitive performance psychosis significant improvement working memory observed nac treated group compared placebo however preliminary data require replication glutamatergic compounds nac may constitute step towards development useful therapies cognitive impairment psychosis
prior research finds sexually permissive individuals judged negatively nonpermissive peers placing risk social isolation based positive assortment principle preferences similarity attributes close relationships examined whether participants permissiveness mitigated negative judgments permissive others sex friendship context college students evaluated hypothetical sex target either nonpermissive permissive past sex partners friendship relevant outcomes participant permissiveness attenuated negative evaluations however preferences rarely reversed moderation found five outcomes suggesting role permissiveness based positive assortment limited evolutionary concerns may take precedence partial support sexual double standard also found
pacific small island developing states sids among vulnerable impacts climate change besides dependent imported petroleum products world use renewable energy help minimize economic risk associated price volatility fossil fuels region increasingly adopting renewable energy targets policies successful examples deployment pacific sids exist however many barriers persist prevent use region resources larger scale challenges deployment islands grouped six categories lack data need policy regulatory frameworks iii scarcity financial opportunities lack human resources costly infrastructure socio cultural impediments based survey conducted among main stakeholders region within framework pacific region capacity building initiative international renewable energy agency irena carried cooperation secretariat pacific community spc paper identifies specific characteristics challenges context pacific sids provide qualitative assessment identifies recommendations overcome challenges elsevier ltd rights reserved
article deals removal cobalt ions using zinc oxide nanopowder nanomaterial prepared via sol gel method supercritical drying nanomaterial characterised via xrd sem edx ftir bet surface area techniques kinetics equilibrium thermodynamic studies metal ions adsorption nanomaterial conducted batch mode experiments varying parameters contact time initial ion concentrations nanoparticles dose temperature data revealed significant dependence adsorption process concentration temperature found enhance adsorption rate indicating endothermic nature adsorption adsorption complied well pseudo secondorder kinetics model adsorption process found match langmuir adsorption isotherm zno nanoparticles could successfully remove center dot ions elevated temperature metal ions adsorption could described endothermic spontaneous physisorption process mechanism metal ions adsorption proposed
paper describes novel cyber attack resilient server inspired concept biological diversity server consists several virtual machines running different operating systems different implementations server protocol specification approach based observation implementations affected vulnerability except vulnerabilities specifications shared libraries prototype system built tested evaluate continuity service results showed exploiting vulnerability prototype system could suppress downtime dns service less without false positives
particle swarm optimization pso uses social topology particles share information among neighbors optimization large number existing literatures shown topology affects performance pso optimal topology problem dependent currently lack study issue paper first analyze class deterministic regular topologies regard affect optimality algorithmic parameters number particles topological degree provide guide topology selections pso theoretical analysis numerical experiments performed reported detail theoretical analysis reveals optimality algorithmic parameters dependent computational budget available particular optimal number particles increases unstrictly computational budget increases fixed number particles optimal degree decreases unstrictly computational budget increases condition computational budget exceed constant measuring hardness benchmark function set total regular topologies different numbers particles tested benchmark functions using recently reported data profiling technique numerical experiments verify theoretical derivations based results two formulas developed help choose optimal topology parameters increased ease applicability pso real world problems elsevier inc rights reserved
aim study reports structural modeling molecular dynamics profiling hypothetical proteins chlamydia abortus genome database methodology hypothetical protein sequences extracted abortus llg genome database functional elucidation using silico methods results fifty one proteins roles defense binding transporting biomolecules unraveled forty five proteins found nonhomologous proteins present hosts infected abortus proteins related virulence structural modeling two proteins first phosphorylase second chlamydial protease proteasome like activity factor accomplished conserved active sites necessary catalytic function analyzed conclusion finally concluded proteins envisioned possible targets developing drugs curtail chlamydial infections however validated molecular biological methods graphics lay abstract sequencing technologies generated abundant data genome proteins organism hypothetical proteins whose existence predicted computational analysis genes protein sequences practical evidence prove lacking study predicts functions hypothetical proteins chlamydia abortus computational bioinformatics methods determining structures structural genomics homology modeling known proteins annotating possible catalytic sites findings may helpful evolving strategies curtail chlamydia abortus infection
state space model railway part track circuits built based kirchhoff voltage law kirchhoff current law observers designed corresponding kinds component capacitor open fault normal state without fault track circuit residual generated computing difference output original system observers fault diagnosis achieved finally using coding set simulink results show proposed scheme able diagnosis faulty capacitor real time also robust noises disturbances
mining waste generated mining mineral raw materials utilization mining wastes many organizations dealing mining industry important reduce negative impacts environment less reshaping landscape take less place landfill waste recovery economic benefit organization least also directs law article discusses use mining waste czech republic method compared possibilities use extractive waste poland concerning mining waste quarries wastes become secondary materials construction must meet requirements construction materials engineering country different requirements materials engineering therefore necessary deal legal aspects use mining waste
aim investigate impact pparg apoe gene single nucleotide polymorphisms snps additional gene gene interaction late onset alzheimer disease load risk based chinese han population total participants males females mean age years old included study including load patients normal controls participants logistic regression performed investigate association snp load risk generalized multifactor dimensionality reduction gmdr used analysis gene gene interaction logistic regression analysis showed load risk significantly higher carriers allele polymorphism versus adjusted higher carriers allele polymorphism versus adjusted also found potential gene gene interaction participants genotype highest risk compared participants genotype covariates adjustment allele apoe allele ppar polymorphism associated increased load risk participants genotype highest risk
background men biochemical recurrence prostate cancer following local therapies often use natural supplements attempt delay metastases avoid need aggressive treatments undesirable side effects growing body research phytotherapeutic agents cohort promising results yet definitive recommendations made pilot study undertaken assess feasibility fully powered study examine effects phytotherapeutic intervention containing turmeric resveratrol green tea broccoli sprouts psa doubling time men biochemical recurrence moderate psa rise rate methods double blind randomized placebo controlled parallel trial conducted men biochemically recurrent prostate cancer moderate rise rate psa doubling time months evidence metastases conventional imaging methods patients randomized either active treatment arm placebo weeks primary endpoints feasibility study recruitment procedures measurement proposed secondary endpoints prostate symptoms quality life anxiety depression measured eortc qlq ipss hads data collected estimate psa log slopes psa doubling times using mixed model pre intervention post intervention periods results adherence study protocol excellent phytotherapeutic intervention well tolerated similar numbers mild moderate adverse events active placebo arms intervention data collection methods acceptable participants statistical difference groups clinical outcomes expected pilot study subject variation psa post treatment average active treatment group experienced non significant increase log slope psa pre treatment doubling time months post treatment doubling time months placebo group experienced change log slope psa pre treatment doubling time months post treatment doubling time months conclusion findings suggest fully powered study combination feasible men biochemically recurrent prostate cancer moderate psa rise rate wiley periodicals inc
recent years witnessed processor development trend integrates central processing unit cpu graphic processing unit gpu single chip integration helps save host device data copying discrete gpu usually requires also introduces deep resource sharing possible interference cpu gpu work investigates performance implications independently running cpu gpu programs platforms first perform comprehensive measurement covers wide variety factors including processor architectures operating systems benchmarks timing mechanisms inputs power management schemes measurements reveal number surprising observations analyze observations produce list novel insights including important roles operating system context switching power management determining program performance subtle effect cpu gpu data copying finally confirm insights case studies point promising directions mitigate anomalous performance degradation integrated heterogeneous processors
operational modal analysis primary tool modal parameter identification civil engineering bayesian statistics offers ideal framework analyzing uncertainties associated identified modal parameters however exact bayesian formulation usually intractable due high computational demand obtaining posterior distributions modal parameters paper variational bayes method employed provide approximate solution unlike laplace approximation monte carlo sampling variational bayes approach provides gradient free algorithm analytically approximate posterior distributions working state space representation dynamical system variational bayes approach identification modal parameters derived ignoring statistical correlation latent variables model parameters approach joint distribution state transition observation matrices well joint distribution process noise measurement error firstly calculated analytically using conjugate priors distribution modal parameters extracted obtained joint distributions using first order taylor series expansion robust implementation method discussed using square root filtering cholesky decomposition proposed approach illustrated application example mass spring system one rincon hill tower san francisco
purpose characterize prevalence contributing factors adult obesity common recurrent copy number variation cnv deletion given rare cnvs known obesity phenotypes methods adults deletion syndrome used available height weight measurements calculate body mass index bmi recorded associated factors could play role obesity used maximum bmi per subject logistic regression test model predicting obesity class results prevalence obesity bmi median age years significantly greater canadian norms odds ratio confidence interval even exduding individuals history antipsychotic use regression model significant psychotropic medication use age sex presence intellectual disability associated higher obesity level ten individuals diagnosed type diabetes median age years prevalence higher obesity conclusion results suggest adult obesity related deletion findings expand potential genetic causes obesity important implications management
growing consensus fuller understanding social cognition depends systematic studies real time social interaction studies require methods deal complex dynamics taking place multiple interdependent temporal spatial scales spanning sub personal personal dyadic levels analysis demonstrate value adopting extended multi scale approach analyzing movement time series generated study embodied dyadic interaction minimal virtual reality environment perceptual crossing experiment reduced movement variability revealed interdependence social awareness social coordination accounted either subjective objective factors alone picks interactions subjective objective conditions convergent elevated coordination perceived clearly social impaired coordination perceived socially ambiguous finding consistent claim interpersonal interaction partially constitutive direct social perception clustering statistics allan factor salient events revealed fractal scaling complexity matching defined similarity scaling laws significantly pronounced pairs participants compared surrogate dyads highlights multi scale distributed character social interaction extends previous complexity matching results dyadic conversation non verbal social interaction dynamics trials successful joint interaction also associated increase local coordination consequently local coordination pattern emerges background complex dyadic interactions pce task makes joint successful performance possible
increasing usage smartphones daily life received considerable attention academic industry driven research utilized health sector development variety health related smartphone applications currently however none applications based nurses historical behavioral preferences mobile application development health care sector requires extensive attention security reliability accuracy nursing applications users often required navigate hospital environments select patients support read patient history set action points assist patient shift finally report performance patient related activities relevant information leave day working day nurse often visits different locations patient room different laboratories offices filling reports still limited capability access context relevant information smartphone minimal recourse triangulation triangulation signals fluctuate significantly indoor location positioning therefore providing relevant location based services mobile subscriber become challenging paper addresses gap applying machine learning behavior analysis anticipate potential location nurse provide required services application concept already presented imcom conference paper focuses process ascertain user context process analyzing predicting user behavior finally process displaying information dynamically generated
evaluate mri findings lumbar spines asymptomatic elite junior tennis players lumbar spine mri studies asymptomatic junior elite tennis players male female mean age years age range years standard deviation reviewed two consultant musculoskeletal radiologists using consensus opinion images assessed using accepted classification systems four players abnormality facet joint arthropathy occurred players mild cases synovial cysts cohort occurring presence facet arthropathy disc degeneration noted players mild affected disc herniation noted players broad based focal nerve root compression pars interarticularis abnormalities patients grades grade spondylolisthesis players prevalence facet joint arthropathy disc degeneration disc herniation pars interarticularis fracture lower female players male lower year olds compared year olds significant amount underlying pathology would normally undetected group asymptomatic elite athletes whilst findings detected clinically relevance facilitating appropriate prehabilitation prevent loss playing time potentially career ending injuries
stem cell technologies especially patient specific induced stem cell pluripotency directed differentiation hold great promise changing landscape medical therapies proper exploitation methods may lead personalized organ transplants regenerate organs necessary develop methods assembling differentiated cells functional organ level tissues generation three dimensional human tissue models also holds potential medical advances disease modeling full organ functionality may necessary recapitulate disease pathophysiology specifically true lung diseases animal models often recapitulate human disease present method generation self assembled human lung tissue potential disease modeling drug discovery lung diseases characterized progressive irreversible scarring idiopathic pulmonary fibrosis ipf tissue formation occurs overlapping processes cellular adhesion multiple alveolar sac templates bioreactor rotation cellular contraction addition transforming growth factor beta single cell type mesenchymal organoids resulted morphologic scarring typical seen ipf two dimensional ipf fibroblast cultures furthermore lung organoid may modified contain multiple lung cell types assembled correct anatomical location thereby allowing cell cell contact recapitulating lung microenvironment bottom approach synthesizing patient specific lung tissue scalable system allows development relevant human lung disease models potential high throughput drug screening identify targeted therapies
computer aided inspection cai non rigid parts significantly contributes improving performance products reducing assembly time decreasing production costs cai methods use scanners measure point clouds parts compare nominal computer aided design cad model due compliance non rigid parts inspection supplier client facilities two sets sophisticated expensive dedicated fixtures usually required compensate deformation parts inspection cai methods fixtureless inspection non rigid parts aim scanning parts free state one main challenges distinguish possible geometric deviation defects flexible deformation associated free state work generalized inspection fixture gnif method applied generate prior set corresponding sample points cad scanned models points used deform cad model scanned model via finite element non rigid registration defects identified comparing deformed cad model scanned model fact sample points located close defects results inaccurate estimation defects paper method introduced automatically filter sample points close defects method based curvature von mises stress filtered remaining sample points used new registration allows identifying quantifying defects accurately proposed method validated aerospace parts
introduction water pipe different form tobacco consumption recent years water pipe usage become increasingly widespread thought less harmful cigarettes increases usage long term exposure high carbon monoxide levels due water pipe consumption may cause carbon monoxide poisoning case report present four patients aged consulted emergency department complaints regarding fainting blackout headache three consumed water pipe one non consumer environment water pipe consumed carboxyhemoglobin values patients patients received one session hyperbaric oxygen treatment patients improved clinical situations treatment discharged conclusion water pipe consumption observed form tobacco consumption eastern mediterranean region followed although considered toxic agents filtered water pipe smoke passes water water pipe consumption increases levels carcinogens carbon monoxide nicotine tar blood compared smoking striking carboxyhemoglobin values cases high even higher stove poisoning cases must kept mind non specific symptoms following water pipe consumption may symptoms carbon monoxide poisoning
present paper describes collaboration university pitesti international level educational scientific research master doctoral studies materials engineering filed international cooperation higher education institutions academic research field manifested different ways important characteristics various forms international cooperation cohesion close relations built higher education institutions
prolactin prl secreted pituitary gland response eating mating ovulation increased serum concentration prl pregnancy contributes enlargement mammary glands breasts prepares production milk however high prl levels derived prolactinoma hyperprolactinemia induce physiological disorders infertility early menopause natural compounds isolated chinensis known possess anti oxidative anti inflammatory anti diabetic effects present study examined therapeutic effect chinensis single compounds hyperprolactinemia pituitary gland rat pituitary cells prl expression levels examined using real time pcr western blot assay crude chinensis extract single compound gomisin reduced mrna protein levels prl cells addition cell proliferation prl target gene expression cells modulated chinensis similar vitro experiments crude chinensis extract gomisin reduced prl levels pituitary serum immature female rats results show chinensis single compound gomisin regulators prl production may candidates treatment hyperprolactinemia prolactinoma
current economy downfall showed european countries need new entrepreneurs starting small medium sized technology based enterprises find solutions manufacturing enterprise surveys realised result action oriented model proposed leading development entrepreneurial skills attitudes universities essential stages defining implementing training mentoring course support business ideas trainees incubation science technology parks best business plans individual accompaniment throughout enterprise forming stage international pool experts elaborated model realised four countries concurrent course
support vector regression svr machine learning technique continues receive interest several domains including manufacturing engineering medicine order extend application problems data sets arrive constantly batch processing data sets infeasible expensive accurate online svr aosvr technique proposed aosvr technique efficiently updates trained svr function whenever sample added removed training set without retraining entire training data however aosvr technique assumes new samples training samples characteristics hence value svr parameters used training prediction assumption applicable data samples inherently noisy nonstationary sensor data result propose aosvr varying parameters uses varying svr parameters rather fixed svr parameters hence accounts variability may exist samples accomplish objective also propose generalized weight function automatically update weights svr parameters online monitoring applications proposed function allows lower upper bounds svr parameters tested proposed approach compared results conventional aosvr approach using two benchmark time series data sensor data nuclear power plant results show using varying svr parameters applicable time dependent data
analyzing activities either static postures movements made user complex process done wide range approaches one part existing approaches support recognition focusing analysis specific body parts fact previous publications method introduced activity recognition body angles algorithm capable analysing using single sample activitites allowing selection activity relevant joints able analyse body user selecting subset advantages disadvantages therefore throughout article expose disadvantages applied solution mitigate results evaluation destined clear body parts make easier obtain high accuracy rates recognition work aim give scientific community lessons learned usage different body areas analysis activity recognition
primary hypothyroidism usually leads retardation linear growth delay even arrest puberty juvenile patients rare cases pediatric patients hypothyroidism may present signs vanwyk grumbach syndrome vwgs includes juvenile hypothyroidism delayed bone age pseudoprecocious puberty present study reported rare case vwgs complications including obesity short stature hepatomegaly pituitary hyperplasia addition comprehensive literature review performed illustrate treatment outcome vwgs pediatric patients present study contributed current knowledge regarding diagnosis treatment vwgs pediatric patients
background several countries regions within countries effective national asthma strategy resulting reduction large burden asthma individuals society systematic appraisal extent national asthma strategies world methods global asthma network gan undertook email survey principal investigators gan centres countries one questions national asthma strategy developed country next five years children adults results investigators countries answered question reported national asthma strategy children adults countries strategy children adults strategy least one age group countries high prevalence current wheeze strategies significantly common low prevalence countries respectively interpretation countries national asthma strategy reported large reduction global burden asthma could potentially achieved countries effective asthma strategy seicap published elsevier espana rights reserved
perimenopause period woman life precedes menopause characterized hormonal changes result increased oxidative stress since oxidative stress associated age related diseases perimenopausal symptoms including somato vegetative manifestations nutritional antioxidant supplementation may effective approach minimizing stress mate tea ilex paraguariensis typical inexpensive beverage consumed brazilian south east argentina uruguay increases antioxidant defense hypothesized could minimize oxidative stress perimenopause modulating enzymatic antioxidant defense test analyzed lipid oxidative damage antioxidant defense erythrocytes liver rats treatment female wistar rats aged months proven perimenopause period received day mate tea gavage group water group female rats aged months group received water erythrocytes liver used determine lipid oxidative damage determined malondialdehyde mda superoxide dismutase sod glutathione peroxidase gpx catalase cat activities total plasma antioxidant capacity examined ferric reducing antioxidant power assay frap estrogen radioimmunoassay increased frap change estrogen levels increased sod gpx reduced mda observed tissues studied increased cat activity observed liver confirmed hypothesis capable minimizing oxidative stress period life modulating antioxidant defense elsevier inc rights reserved
parenting multifaceted task way parents fulfill task plays important role children growth development especially early childhood conceptualization assessment parenting behavior elementary research child family development would fill gap clinical work lack questionnaires simultaneously assessing multiple parenting behaviors specific early childhood therefore comprehensive early childhood parenting questionnaire cecpaq designed parent report measure commonly occurring behaviors five domains parenting support stimulation structure harsh discipline positive discipline central early childhood data collected mothers fathers year old children confirmatory factor analysis confirmed five factor structure composed items five parenting domains found good internal consistency temporal stability preliminary evidence validity cecpaq demonstrated moderate relationships measures parental stress child problem behavior concluded cecpaq promising measure self perceived parenting behavior parents year old children
one important tasks network security solutions track network flows real time universe flow identifiers huge hash tables fast operations well suited task order overcome limitations traditional hash tables research community come different improved variants two well knowns cuckoo peacock hash tables yet network flows interesting characteristics exploited tracking flows efficiently besides existing hash tables vulnerable attacks context design develop evaluate rex resilient efficient data structure tracking network flows rex designed make good use characteristics internet traffic well different memory technologies rex stores commonly updated flows faster smaller sram storing rest dram conducted extensive experiments using real network traffic evaluate compare rex cuckoo peacock hash tables results demonstrate normal attack scenarios rex rejects least number packets also significantly reduces total time taken important hash table operations elsevier rights reserved
children exposed intimate partner violence ipv likely develop behavior problems findings mixed regarding whether girls boys differentially affected bem journal personality social psychology argued gender role important predictor mental health relationship may differ males females due societal gender norms given gendered nature ipv examined whether gender role interacted gender predict behavior problems ipv exposed children among four year old children gender typed gender roles risk factor girls boys androgynous gender roles protective boys girls average however post hoc analyses indicated amount ipv exposure mattered androgynous girls exposed chronic ipv behavior problems results illustrate importance societal family gender norms determining children risk behavior problems following exposure ipv
adult victims child physical abuse cpa likely perpetrate intimate partner violence ipv nonvictims however cpa victims become violent toward partners suggesting factors moderate risk ipv perpetration drawing background situational model riggs leary study examines independent interactive effects cpa history negative affect arising conflict intimate partner predicting physical ipv perpetration fifty three heterosexual dating couples completed questionnaires assessing cpa history perpetration physical ipv couples discussed largest source conflict relationship min videos discussions coded negative affect using actor partner interdependence model approach account dyadic interdependence data findings revealed average levels negative affect cpa severity predicted greater ipv perpetration men women however average levels cpa negative affect conflict positively predictive ipv perpetration men findings revealed interaction men positive association cpa severity ipv perpetration became stronger negative affect conflict increased
disciplinary boundaries become increasingly unclear grappling wicked problems present complex set policy cultural technological scientific dimensions shaped professionals individuals depth breadth expertise called upon play critical role complex problem solving paper unpacks notion shaped expert seeks situate within broader academic literature expertise integration developmental learning component project includes exploratory study aimed evaluating emergent attributes shaped expertise two different educational programs completed january may two programs build disciplinary knowledge science technology engineering mathematics fields core vertical dimension expanding students awareness comprehension expertise horizontal dimension courses introduced science engineering students case study topics focusing around complex human technological ecological systems nanotechnology society course governance genetically modified organisms gmos science technology society course analyze pre post test data pilot project presenting findings pertain student learning well variants methodology reflect utility limitations selected methodology evaluating expertise evolves time paper closes discussion theory acquisition implications delineating early attributes characteristics shaped expertise
observability system respect possible outputs usually evaluated using rank criterion observability matrix observability indices addition paper uses properties differential equations characterizing real time electrical circuits base nonlinearities exponential function interplay mathematical tools practical considerations done observability coefficients observability matrices high order sliding mode observers colpitts chaotic system representative nonlinearities
paper focuses development distributed surface machining system traditional manufacturing engineering activity analysis conducted developing proposed system structure advantages distributed system structure easy manage high expandability flexibility enhance efficiency integral system operation achieve goal networked manufacture idef used describe stage traditional surface machining activities uml unified modeling language technology adopted verify feasibility accuracy established integrated system developed distributed system structure sub functional modules cad cam capp haze implemented based proposed systematic approach freeform surface used example verification proposed approach successfully implemented could adopted assist engineers integrating machining activities located dispersed places various domains experts also exchange expertise among thus development time product machining processes shortened enhancement competitive advantages addition distributed system also integrated multi functional ontology service agent facilitate selection reconfiguration manufacturing customization proposed system presented feasibility incorporating agent based technology distributed freeform surface machining environment service agents communicate via pre defined performatives underlying knowledge query manipulation language kqml surface machining capability developed system successfully demonstrated feasibility implementing agent based technology distributed surface machining system
chronic obstructive pulmonary disease copd lung cancer devastating pulmonary diseases commonly coexist present number clinical challenges copd confers higher risk lung cancer development available chemopreventive measures remain rudimentary current studies shown marked benefit cancer screening copd population although challenges remain including common underdiagnosis copd copd associated lung cancer presents distinct clinical features treatment lung cancer coexisting copd challenging copd may increase postoperative morbidities decrease survival review outline current progress understanding clinical association copd lung cancer suggest possible cancer prevention strategies patient population
visual cryptography developed significant research arena media security despite obvious strengths recent investigations debated scheme adverse aspects problem lack authentication shares authentication related digital image processing cryptography fully integrated together past years paper analyze visual features cryptographic features shares take use authentication compared existing methods contribution first one integrate visual features cryptographic features shares hash code purpose authentication
large eddy simulation les approximate deconvolution model combined lagrangian particles simulation lps simulating turbulent reactive flows high schmidt numbers les used simulate velocity nonreactive scalar reactive scalars simulated lps using mixing volume model molecular diffusion les lps applied turbulent scalar mixing layers second order isothermal irreversible reaction mixing volume model implemented iem curl modified curl mixing schemes mixing volume model provides correct decay rate nonreactive scalar variance high independently number particles statistics les lps iem modified curl mixing scheme agree well experiments moderately fast rapid reactions however lps curl mixing scheme overpredicts effects rapid reaction american institute chemical engineers
integrated circuits design research laboratory southern illinois university edwardsville siue collaborated nuclear reactions group washington university develop family multi channel integrated circuits date collaboration successfully produced two micro chips first analog shaped peak sensing chip board constant fraction discriminators sparsified readout chip known heavy ion nuclear physics channel hinpc second chip christened psdc designed logically complement terms detector types hinpc chip pulse shape discrimination channel psdc featuring three settable charge integration windows per channel performs pulse shape discrimination psd paper summarizes design capabilities features hinpc psdc ics proceeds discuss modifications made ics associated systems attempted improve ease use increase performance extend capabilities paper concludes brief discussion may next chip employing multi sampling scheme added cmos asic tool box radiation detection instrumentation elsevier rights reserved
aims upregulation substance neurokinin receptor nkr activation induces pro inflammatory bladder hyperactivity pkc erk kappa icam signaling pathways increase leukocyte infiltration adhesion leading reactive oxygen species ros production autophagy apoptosis theanine unique non protein forming amino acid present tea camellia sinensis kuntze antioxidant antiinflammatory relaxation effects improve cognition mood gastric ulcer injury cerebral ischemia reperfusion injury posttraumatic stress disorder explored protective effect theanine induced bladder hyperactivity methods urethane anesthetized female wistar rats explored transcystometrogram pelvic nerve activity proinflammatory pkc erk icam signaling apoptosis related caspase poly adpribose polymerase parp autophagy mediated expression western blot electrophoretic mobility shift assay immunohistochemistry bladder ros amount ultrasensitive chemiluminescence method possible ros sources different leukocytes specific stains evoked hyperactive bladder results theanine dose dependently depressed hocl activity vitro urethane anesthetized female wistar rats intra arterial nkr activation increased voiding frequency shortened intercontraction intervals associated increase bladder nerve activity proinflammatory pkc erk icam signaling caspase parp mediated apoptosis mediated autophagy ros amount neutrophils adhesion monocyte macrophage infiltration mast cells degranulation hyperactive bladder intragastrical theanine twice daily weeks efficiently ameliorated enhanced parameters treated hyperactive bladder conclusions conclusion theanine antioxidant anti inflammatory actions ameliorates induced bladder hyperactivity via inhibition proinflammatory pkc erk icam signaling oxidative stress bladder nerve hyperactivity apoptosis autophagy wiley periodicals inc
target study instantaneous electromagnetic force acquisition stator side reduce vibration paper electromagnetic force acquired displacement measured strain gauge using switched reluctance motor salient poles displacements stator rotor arc measured measured results compared simulation results experimental results measured acceleration sensor thus effectiveness method examined
linear momentum actuator disc theory extended address power available tidal turbine array spanning cross section open channel flow generalised formulation presented relaxes constraints previous models froude number flow geometry turbine array also considers effects far wake mixing overall power removed flow limiting case free surface deformation rigid lid model recovered blockage ratio turbine frontal area cross sectional area surrounding flow passage greatest effect available power peak power coefficient increasing blockage ratio increases increase peak power coefficient achieved froude number increases efficiency energy extraction may determined relative total power extracted flow comprising power available turbines power dissipated wake mixing higher blockage turbines operating low thrust coefficients shown efficient lower blockage turbines
western societies glorify youth consider middle age onset deterioration prevalent discourses middle aged women focus primarily negative developments lives increased health risks menopause little known however lived experiences age group article share information health ageing related attitudes women aged years took part physical activity intervention denmark drawing foucault concepts disciplinary power governmentality explored via semi structured interviews women reasons participation experiences playing team game interviews revealed internalized messages healthy ageing felt guilty previous inactive lifestyle however participation also influenced changing life circumstances time exercise contrary previous experiences found playing games provided pleasure
objective traumatic brain injury causes substantial morbidity mortality children posttraumatic seizures may worsen outcomes traumatic brain injury posttraumatic seizures risk factors completely understood objective clarify posttraumatic seizures risk factors large cohort children severe traumatic brain injury design retrospective cohort study probabilistically linked dataset national trauma data bank pediatric health information systems database setting twenty nine children hospitals patients total children age old admission linked national trauma data bank pediatric health information systems records severe emergency department glasgow coma scale traumatic brain injury hospital length stay hours nonmissing disposition interventions none measurements main results outcome posttraumatic seizures identified using validated international classification diseases revision clinical modification diagnosis codes prespecified candidate predictors posttraumatic seizures included age injury mechanism emergency department glasgow coma scale intracranial hemorrhage type hypoxia hypotension cardiac arrest posttraumatic seizures diagnosed children severe traumatic brain injury without abuse assault subdural hemorrhage posttraumatic seizures rate varied less years old years old age abusive mechanism subdural hemorrhage significant predictors posttraumatic seizures risk posttraumatic seizures complex relationship predictors estimated odds posttraumatic seizures decrease advancing age odds ratio equal per additional year age abuse assault subdural hemorrhage odds ratio equal per additional year age abuse subdural hemorrhage present infant accidental traumatic brain injury subdural hemorrhage approximately estimated probability posttraumatic seizures abused infant without subdural hemorrhage triad young age injury abuse assault subdural hemorrhage confers greatest estimated probability posttraumatic seizures conclusions posttraumatic seizures risk children severe traumatic brain injury greatest triad younger age injury abuse assault subdural hemorrhage however posttraumatic seizures common even absence factors
psoriasis disease characterized imbalance inflammatory axes cutaneous mesenchymal stem cells mscs early involved show greater relative expression several genes encoding cytokines therapeutic implications tnf inhibitors differentiated skin cells largely described psoriasis however effects mscs derived patients psoriasis partially described aim work evaluate effect tnf inhibitors cytokine milieu expressed mscs isolated skin patients psoriasis resident mscs skin patients psoriasis healthy subjects isolated characterized profiled pcr elisa expression cytokines involved pathways weeks therapy tnf inhibitors administration tnf inhibitors weeks acts mscs follows reduces expression several cytokines whose levels elevated baseline ifn tnf ccl ccl cxcl cxcl csf similarly enhances expression several cytokines underexpressed baseline reducing expression overexpressed baseline tgf tnf inhibitors could contribute reduce pathological imbalance axis mscs patients psoriasis
matrix commonly used scientific computing engineering calculation concerned data data structures store elements make operations run effectively main task compressed storage make nonzero elements share storage unit according distribution elements time lots zero elements allocate storage space article discussed multidimensional compressed storage upper half banded matrix obtained row major compressed storage address mapping functions column major compressed storage address mapping functions first time also two kinds compressed storages high compression storage ratio hope conclusion provide basic data storage theory engineering calculation scientific computing
design nuclear power plants various natural circulation passive cooling systems considered remove residual heat reactor core event power loss maintain plant safety passive systems rely gravity differences fluids resulting density differentials rather using external power driven system unfortunately major drawback systems weak driving force negatively impact safety systems temperature difference heat source heat sink potentially offers natural platform thermoelectric generator teg applications previous study designed analyzed teg based passive core cooling system paper considers teg applications passive cooling systems nuclear power plants concept teg based passive cooling system proposed system electricity produced using system temperature differences teg electricity used enhance cooling process
weighted median filtering fundamental operator great variety image processing computer graphics applications paper presents novel real time weighted median filter smoothes high frequency details preserving major edges define new bilateral grid incorporating bilateral grid additional range dimension edge aware weights weighted median values computed space proposed algorithm highly parallel enabling real time gpu based edge aware implementation experimental results show algorithm run efficiently real time modern gpus applications including jpeg artifact removal image stylization demonstrated verify feasibility proposed weighted median filtering algorithm
investigated adsorption isotherms thermodynamics adsorption kinetics salt onto zeolites adsorption isotherm studied using langmuir freundlich temkin dubinin radushkevich models separation factor indicates nature adsorption process favorable adsorption physical indicated high adsorption intensity small mean free energy mol negative mol indicates spontaneous nature adsorption negative mol confirms exothermic nature adsorption process whereas negative mol suggests configuration adsorbate zeolite surface less random pseudo second order kinetic model well fits experiment data based characteristics adsorption isotherms thermodynamic adsorption kinetics zeolite potential seawater desalination process published elsevier
electrical phenomena morphing structures venus flytrap attracted researchers since nineteenth century observed mechanical stimulation trigger hairs lobes venus flytrap induces electrotonic potentials lower leaf electrostimulation electrical circuits venus flytrap induce electrotonic potentials propagating along upper lower leaves instantaneous increase decrease voltage stimulating potential generates nonlinear electrical response plant tissues electrostimulation instantaneous sinusoidal triangular functions results linear responses form small electrotonic potentials amplitude sign electrotonic potentials depend polarity amplitude applied voltage electrical stimulation lower leaf induces electrical signals resemble action potentials trap lobes midrib trap closes stimulating voltage threshold level electrical responses venus flytrap analyzed reproduced discrete electrical circuit information gained study used elucidate coupling intracellular intercellular communications form electrical signals within plants elsevier gmbh rights reserved
nicotinamide adenine dinucleotide nad biosynthetic pathway mediated nicotinamide phosphoribosyltransferase nampt key nad biosynthetic enzyme plays pivotal role controlling many biological processes metabolism circadian rhythm inflammation aging past decade nampt mediated nad biosynthesis together key downstream mediator namely nad dependent protein deacetylase sirt demonstrated regulate glucose lipid metabolism tissue dependent manner discoveries provided novel mechanistic therapeutic insights obesity metabolic complications insulin resistance important risk factor developing type diabetes cardiovascular disease review focus importance adipose tissue nampt mediated nad biosynthesis sirt pathophysiology obesity insulin resistance also critically explore translational clinical aspects adipose tissue nad biology
symbolic computation paper investigates integrable properties two dimensional generalization korteweg vries equation bogoyavlensky konoplechenko model govern interaction riemann wave propagating along axis long wave propagating along axis within framework bell polynomial manipulations bell polynomial expressions firstly given cast bilinear forms soliton solutions form order polynomial exponentials terms wronskian determinant respectively constructed hirota bilinear method wronskian technique bilinear backlund transformation also derived achievement family explicit solutions
paper examines effect energy production health using recent strike affected oil refineries france natural experiment first show temporary reduction refining led significant reduction sulfur dioxide concentrations second shock significantly increased birth weight gestational age newborns particularly exposed strike first third trimesters pregnancy decreased asthma bronchitis admissions back envelope calculations suggest unit decline monthly leads sic million increase lifetime earnings per birth year cohort externality oil refineries important part policy discussions surrounding production energy
aims objectives identify examine existing research exploring people dementia nurses view acute hospital care background admission hospital traumatic person dementia due inability cope unfamiliar environments faces routines adverse behavioural health outcomes result dementia adds complexity patient care inability deliver appropriate care source stress frustration nurses methods integrative review literature reporting experience people dementia nurses caring acute hospital setting results hospitals focus acute medical care consequently people dementia considered low priority disruption normal routine risk management often takes priority patient dignity people dementia stigmatised families significant roles play care person dementia hospital often excluded nurses struggle complete even basic patient care focus tasks often expense specific patient needs support nurses lacking job satisfaction nurses caring people dementia poor conclusions nurses require improved education support care patients dementia hospitals must focus genuine caring concurrently rapid discharge requirements risk mitigation fiscal restraint research needed inform development appropriate care people dementia hospitals relevance clinical practice nurses must understand complex needs people dementia hospital nurse education dementia practical support strong clinical leadership role modelling needed empathy patients regardless diagnosis must remain core attribute nurses current hospital culture requires wider system review mitigate stigmatisation patients dementia
technical note provides necessary sufficient conditions determine linear system one matrix state space representation decomposed cascade separate sub systems order perform decomposition one needs determine linear transformation matrix furthermore given conditions adapted simple effective condition derive possible scalar sub systems given linear system numerical examples provided demonstrate applicability presented results
children spend majority weekdays classrooms often low indoor air quality limited financial resources initial running costs mechanical ventilation systems designing effective natural ventilation systems schools difficult due intense use classroom spaces dependence building geometry outdoor conditions building thermal airflow simulation tools fundamental predict system performance design phase predictions tools must validated preferably data real buildings paper presents set detailed measurements buoyancy driven natural systems three classrooms located two buildings lisbon portugal rooms located two educational buildings kindergarten university different buoyancy driven natural systems without chimneys experimental measurements used validate three node model implemented open source thermal building simulation software energyplus validation results show building thermal simulation model tested able predict bulk airflow rate average error addition good agreement also obtained vertical temperature prediction average error corresponding average deviation degrees analysis kindergarten rooms results revealed expected increasing chimney height significant positive impact system performance performance natural systems depends number thermal plumes room sensible heat load increasing number plumes lowers average occupied zone air temperature increases bulk airflow rate light complexity cases tested uncontrolled boundary conditions results comparisons performed measurements simulations contribute increase confidence use energyplus simulate buoyancy driven natural systems elsevier rights reserved
recurrent deletion genetic risk factor early onset parkinson disease adults associated deletion syndrome may exhibit phenotypes could help identify highest risk reveal disease trajectories investigated clinical neuroimaging features relevant parkinson disease adults genetic risk parkinson disease mean age years standard deviation healthy age sex matched controls patient dopa responsive early onset parkinson disease neuroimaging included transcranial sonography positron emission tomography using dihydrotetrabenazine dtbz radioligand binds presynaptic vesicular monoamine transporter group without parkinson disease demonstrated significant motor olfactory deficits relative controls eight clinically classified parkinsonism transcranial sonography showed significantly larger mean area substantia nigra echogenicity risk group compared controls patient parkinson disease showed expected pattern severely reduced striatal dtbz binding group without parkinson disease however showed significantly elevated striatal dtbz binding relative controls similar results similar within group without psychotic illness findings suggest manifestations parkinsonism evolution parkinson disease genetic risk population may include hyperdopaminergic mechanism adequately powered longitudinal studies animal models needed evaluate relevance observed clinical imaging phenotypes parkinson disease disorders prevalent schizophrenia
irinotecan metabolite ethyl hydroxycamptothecan damage gonads male female prepubertal mice irinotecan metabolite reduces germ cell numbers within seminiferous tubules mouse testes concentrations relevant cancer patients contrast little effect female germ cell population little known role chemotherapeutic agent irinotecan female fertility one article date reporting menopausal symptoms perimenopausal women treated irinotecan data available either adult male fertility impact irinotecan subsequent fertility prepubertal cancer patients female male male female gonads obtained postnatal day cbl mice exposed vitro range concentrations irinotecan metabolite testis ovary treated gonads compared control gonads exposed dissolved dimethyl sulfoxide controls exposed concentration diluent number testis fragments used analysis ranged per treatment group number ovaries used analysis ranged per treatment group neonatal mouse gonads developed vitro tissue analysed end day culture period following immunofluorescence hematoxylin eosin staining statistical analyses performed using one way anova followed bonferroni post hoc test normally distributed data kruskal wallis test followed dunns post test non parametric data abnormal testis morphology observed tissues exposed smaller seminiferous tubule diameter highest concentration versus control increased number sertoli cell tubules two highest concentrations versus control within seminiferous tubules dose response decrease observed germ cell number mouse vasa homologue mvh positive cells proliferating cell number bromodeoxyuridine brdu positive cells significance reached two highest concentrations mvh brdu versus control change seen protein expression apoptotic marker cleaved caspase double immunofluorescence showed occasional proliferating germ cells present treated testes even exposure highest drug concentration prepubertal ovaries treated effect seen germ cell number apoptosis cell proliferation even exposure highest drug concentrations study using vitro experiments experimental animal model caution required extrapolating present findings humans differences human mouse spermatogonial development also need considered assessing effect chemotherapeutic exposure however prepubertal testes ovaries used present studies contain germ cell populations representative found prepubertal patients experimental tissues exposed drug concentrations within range found patient plasma findings demonstrate prepubertal mouse ovary relatively insensitive exposure irinotecan metabolite induces marked dose dependent sensitivity testicular germ cell population study identifies importance investigation identify risk infertility young male cancer patients treated irinotecan none work supported medical research grant mrc grant children cancer grant authors declare conflict interest could prejudice impartiality present research
men involvement maternal child healthcare especially patriarchal societies ghana increasingly advocated number studies conducted explore men views involvement studies examined perspectives childbearing women based qualitative focus group discussions conducted january august total adult women seven communities upper west region ghana paper examines women perspectives men involvement maternal child healthcare findings suggest although many women recognised benefits men involvement actually supported greater male involvement majority women expressed negative attitudes opinions involvement men negative attitudes opinions framed three broad factors perceptions pregnancy child care female role men bread winners women desire avoid negative stereotyping fears men involvement may turn hitherto secure social spaces women insecure ones narrative accounts largely challenge current programmatic efforts seek promote men involvement maternal child healthcare suggest male involvement programmes less likely succeed views concerns childbearing women taken account elsevier ltd rights reserved
increasing demands military detection wireless communication remote sensing make spectrum even crowded radar sequence design meeting spectral compatibility requirement challenging urgent problem study devoted designing optimised phase coded sequences keep spectral compatible overlaid electromagnetic radiators time optimise signal interference plus noise ratio sinr first intelligent dynamic spectrum information around radar system achieved radio environmental map information introduced form constrained optimisation process aimed improving spectral compatibility radar detection performance second unimodularity requirement necessary make full use transmit power similarity constraint enforced keep desired ambiguity function feature third resolve resulting non convex optimisation quadratically constrained quadratic problem relaxation randomisation procedure applied therefore technique behaves polynomial computational complexity finally performance analysis given show effectiveness terms sinr spectral shape resulting auto correlation function
purpose use green wall technology green buildings growing trend however research required maintainability taking account maintainability design stage valuable strategy achieving building efficiency sustainability thus purpose paper determine issues operating maintaining green walls particularly tropical areas like singapore leading development green maintainability framework design methodology approach research uses qualitative method combines thorough systematic literature review multiple case studies field observation surveys selected instrumental case studies building plan appraisal interviews investigate potential issues associated maintainability green walls tropical areas like singapore findings findings show technical environmental issues defects prevalent operation maintainability green wall technologies applied green buildings located tropical regions proper considerations findings encourage green building designers facilities managers collaborate effective implementation operations maintenance green building technologies originality value research gives new significant information identifying clear knowledge gap paper recommends formulation green maintainability framework set design criteria serve benchmark future design green walls green maintainability framework would valuable addition green facilities management ensuring long term maintainability sustainability existing new green walls tropical areas specifically singapore
breast cancer become common disease around world expert systems valuable tools successful disease diagnosis research accordingly develop new knowledge based system classification breast cancer disease using clustering noise removal classification techniques expectation maximization used clustering method cluster data similar groups use classification regression trees cart generate fuzzy rules used classification breast cancer disease knowledge based system fuzzy rule based reasoning method overcome multi collinearity issue incorporate principal component analysis pca proposed knowledge based system experimental results wisconsin diagnostic breast cancer mammographic mass datasets show proposed methods remarkably improves prediction accuracy breast cancer proposed knowledge based system used clinical decision support system assist medical practitioners healthcare practice elsevier ltd rights reserved
men women manifest different symptoms depression current diagnostic criteria depression twice prevalent woman however little known mechanisms contributing important sex differences sub chronic variable stress scvs rodent model depression induces depression like behaviors female mice modeling clinical evidence higher susceptibility mood disorders women accumulating evidence indicates altered neuroplasticity excitatory synapses nucleus accumbens nac key pathophysiological feature susceptibility social stress males investigated effects scvs pre post synaptic protein levels morphology glutamatergic synapses medium spiny neurons msns nac female male mice animals underwent six day exposure alternating stressors including shock tail suspension restraint msns nac filled lucifer yellow dye spine density type examined using neuronstudio separate group animals immunofluorescence staining performed vesicular glutamate transporter vglut vesicular glutamate transporter vglut order label cortical subcortical glutamatergic terminals immunostaining post synaptic density psd employed evaluate post synaptic density females demonstrated circuit specific pre synaptic alterations vglut vglut containing synapses may contribute stress susceptibility absence post synaptic alterations psd puncta spine density type data indicate susceptibility stress females associated changes frequency distinct glutamatergic inputs nac ibro published elsevier ltd rights reserved
introduction able understand people emotions intentions crucial social interactions well deficits theory mind tom functioning hamper ability observed depression neuropsychiatric disorders however results previous research depression inconclusive possibly due presence comorbid disorders disregarding modulating factors methods thirty eight patients major depressive disorder mdd forty healthy matched controls assessed tom task using animated triangles results correlated attachment styles empathy abilities neurocognitive performance results findings show healthy female controls performed significantly stronger tom task female mdd patients performance differences driven attachment styles depression severity impact task performance limitations pharmacological treatment majority patients might limit generalizability study discussion results indicate gender specific impact attachment styles tom performance future studies investigate whether impairments social cognitive tasks pose risk factor depression interactional styles vice versa moreover regard remediation programs gender specific needs taken account
progress power engineering continuous increase called non linear loads amount power loads electrical networks result high harmonics production voltage causes number negative effects electrical network equipment functioning valve inverter regulating devices widely used among nonlinear loads devices operate work aimed analyzing high harmonics currents consumed modern widely used non linear electrical devices tvs computers washing machines etc also analyzed operation mode induction motor also equipped acs frequency converter larger number devices used necessary minimize standard values high harmonics current voltage networks
nonlinear reactivity model thermal hydraulic feedback presented analysis pwr fuel various cladding materials simplified batch wise neutronic model requires batch reactivities migration areas predetermined functions burnup temperature fuel coolant design parameters neutronic significance enrichment cladding composition functions found using symbolic regression unique approach finds functional form model coefficients simultaneously core thermal hydraulics modeled using single channel axially averaged values models implemented open source python based tool used analyze fuel based cladding outer protective layers either fecral sic two materials proposed use next generation accident tolerant fuel elsevier ltd rights reserved
authors article respond nekhamkin call answer counterfactual challenge past related question surrendering leningrad course great patriotic war refuting numerous pseudoscientific investigations revisionists history war authors show misanthropic essence third reich plans respect soviet union general leningrad particular using logic alternative history analyze first possible actions military political leadership nazi germany situation similar blockade leningrad second possible military consequences loss city neva river point view military science humanitarian considerations proved actions soviet command defending leningrad right also alternative existed
introduction numerous data sources suggest decline child sexual abuse csa united states since early evidence also indicates earlier period higher csa incidence began following world war study examines prevalence estimates sexual abuse reported retrospectively occurred childhood chsa two nationally representative surveys canadian population methods data respondents aged years canadian gender alcohol culture international study genacis household residents aged years older participated canadian community health survey mental health cchs present inter intrasurvey comparisons chsa prevalence specific sex age groups results findings surveys suggest decline csa since consistent declines observed united states results also suggest period higher risk csa relative period evidence robust women conclusion evidence decline csa canada since early encouraging given long term debilitating effects associated continued monitoring critical long term negative effects associated csa underscore importance continuing move lower risk zero risk
despite widespread inclusion diversity related curricula medical training racial disparities quality care physician bias medical treatment persist present study examined effects formal informal experiences non african american medical students attitudes toward african americans longitudinal study randomly selected medical schools assessed effects experiences related medical training accounting prior experiences attitudes contact african americans predicted positive attitudes toward african americans relative white people even beyond effects prior attitudes furthermore students reported witnessed instructors make negative racial comments jokes significantly willing express racial bias even accounting effects contact examining effects informal experiences racial attitudes may help develop effective medical training environment reduce racial disparities healthcare
session initiation protocol sip signaling communications protocol chosen controlling multimedia communication mobile networks recent years password based authenticated key exchange protocols designed provide strong authentication sip paper address problem two party setting user server try authenticate establish session key using shared password aim propose secure anonymous authenticated key exchange protocol achieve security privacy goal without increasing computation communication overhead analysis show proposed protocol secure computational computational overheads comparable related authentication protocols sip using elliptic curve cryptography proposed protocol also provably secure random oracle model
although concept transforming care promising improving health care consensus field definition aim concept analysis develop deeper understanding term transforming care within nursing discipline order facilitate comprehension implementation evaluation performed comprehensive literature review electronic databases medline pubmed cinahl ebsco cochrane library psycinfo ovid web science wiley blackwell sciencedirect springerlink used walker avant approach analyse concept studies selected analysis main attributes transforming care identified patient centredness evidence based change transformational leadership driven suggest operational definition facilitate implementation concept practice furthermore propose implementation guided following key ideas fostering culture continuous improvement encouraging bottom initiatives promoting patient centred care using transformational leadership lastly evaluation transforming care initiatives assess care processes professionals patients outcomes
paper presents new methodology design multivariable proportional integral derivative pid controllers based decoupling control method presented general processes design procedure ideal decoupling control integral action designed minimise interactions depends desired open loop processes specified according realisability conditions desired closed loop performance specifications realisability conditions stated three common cases define open loop processes studied proposed controller elements approximated pid structure practical point view wind problem also considered new anti wind scheme multivariable pid controller proposed comparisons works demonstrate effectiveness methodology use several simulation examples experimental lab process
population growth made probability incidents large scale crowd events higher ever past decades automated crowd scene analysis done computer vision attracted attention however severe occlusions complex crowd behaviors make analysis challenge key aspect crowd scene analysis number works dealing dense crowd anomaly detection based computer vision presented work survey computer vision techniques analyzing dense crowd scenes covers two aspects crowd density estimation abnormal event detection problems perspectives discussed end
past research demonstrated racial prejudice played significant role presidential election relatively less known relationship prejudice public opinion throughout obama administration present research examined whether racial attitudes associated evaluations obama administration also whether may influenced development general political attitudes early years obama administration investigated question using panel data nationally representative sample americans interviewed september july racial attitudes measured prior election predicted early disapproval president obama handling important issues early disapproval president obama performance turn predicted later perceptions whether state nation improving divergence high prejudice low prejudice individuals perceptions state nation became greater time consistent idea racial attitudes powerfully expressed political judgments time passed
based fluid mechanics theories research focuses numerical simulation analysis capillary flow microgravity fan shaped asymmetric interior corner analyze effect contact angle rising height fan shaped asymmetric interior corner get concus finn condition calculation capillary flow needs satisfy fan shaped asymmetric interior corner study effect different parameters experimental medium container configuration capillary flow fan shaped asymmetric interior corner concus finn condition fulfilled conclusions paper important role guiding analytic solution flow fan shaped asymmetric interior corner microgravity also chose appropriate experimental medium design container based paper
design electric machines motor performance cost manufacturing considered hence researchers called multi objective optimization moo problem goal minimize maximize several objective functions time order solve moo problem various algorithms nondominated sorting genetic algorithm multi objective particle swarm optimization widely used algorithms applied electric machine design much time consumption inevitable due many times function evaluations using finite element method solve problem novel surrogate assisted moo algorithm proposed validity confirmed comparing optimization results test functions conventional optimization methods verify feasibility application practical electric machine interior permanent magnet synchronous motor designed
introduction investigation conversion rates normal cognition mild cognitive impairment mci important effective early intervention could potentially prevent substantially delay onset dementia however reported conversion rates differ across studies recruitment source study examined predictors conversion mci racially ethnically diverse sample drawn community clinic recruitment sources methods rates predictors conversion assessed ongoing prospective longitudinal study university california davis alzheimer disease center participants recruited clinic community sample clinically confirmed cognitively normal baseline followed seven years recruitment source demographic factors age gender race ethnicity year education apoe epsilon positive cognitive measures senas test scores functional assessments cdr sum boxes neuroimaging measures total brain volume total hippocampal volume white hyperintensity volume assessed predictors conversion cognitively normal mild cognitive impairment using proportional hazards models results participants clinic community progressed mci clinic based sample showed annual conversion rate per person year whereas community based sample showed conversion rate per person year risk factors conversion include clinic based recruitment older lower executive function worse functional assessment baseline smaller total brain volume discussion older adults sought clinical evaluation even found normal cognition increased risk subsequent development mci results consistent studies showing subjective cognitive complaints risk future cognitive impairment extend findings show seek evaluation complaints particularly high risk moreover individuals subtle significant differences functional cognitive abilities presence concerns evidence atrophy brain imaging warrant continued clinical follow risk factors could also used stratification variables dementia prevention clinical trial design alzheimer association published elsevier inc rights reserved
power systems getting complicated load centers get connected network thus forming power grids since black outs power systems become common interconnected system loss generation one area replaced generation areas thus several systems interconnected survive contingencies individual systems could thus one benefit interconnected power systems potential increased reliability paper discusses implementation automatic load transfer program ring electrical network using supervisory control data acquisition scada system automates electric power system operations thus maintaining reliability
aims determine lower urinary tract symptoms luts prevalence urodynamic findings amyotrophic lateral sclerosis als patients treated hospital methods cross sectional descriptive study cohort als patients validated questionnaires iciq ipss oab self administered order evaluate presence luts symptoms classified clinically significant csluts following scores ipss iciq oab present urodynamic study offered csluts patients physical examination prostate ultrasound also performed results fifty five seventy nine als patients accepted participate study patients met criteria csluts patients reported urgency urinary incontinence csluts patients complained mixed symptoms qol measured ipss scoring mostly dissatisfied unhappy average qol iciq scoring complained moderate severe bother ten twenty four csluts patients consented uds frequent finding detrusor overactivity obstruction due non relaxing external sphincter five patients bladder neck two patients two patients showed normal bladder filling non relaxing external sphincter voiding uds normal one patient conclusions small pilot study found high prevalence csluts als mainly related combination voiding storage symptoms patients symptoms caused overactive detrusor combined non relaxing sphincter severity symptoms impact qol moderate subset patients considerable neurourol urodynam wiley periodicals inc
paper demonstrates interact conversational agent speaks actual human body face face person offscreen made possible cyranoid method technique involving human person speech shadowing remote third party receiving words via covert audio relay apparatus repeating aloud real time person shadows artificial conversational agent source call resulting hybrid echoborg report study people encountered conversational agents either human shadower face face via text interface conditions assumed interlocutor actual person results show perception conversational agent dramatically altered agent voiced actual tangible person discuss potential implications methodology development conversational agents general person perception research
aim study describe need profile outpatients schizophrenia belonging aymara ethnic group latin america compare profile non aymara patients sample patients evaluated two way communication checklist com checklist measuring needs satisfaction patient positive negative syndrome scale schizophrenia panss attitude drugs dai significant differences found aymara non aymara either total number needs subscales satisfaction types needs adjustment socio demographic clinical factors patients higher severity panss higher number needs lower level satisfaction higher score dai related higher total number needs better satisfaction medication age sex ethnicity employment also associated specific needs profile needs schizophrenic aymara patients differ non aymara patients groups necessary treatment primarily address symptom management subjective aspects quality life
study analyzed real working parameters otto cycle internal combustion engine using fuel hydrogen plus gasoline two stoichiometric equations determined first equation reagents octane air second equation added quantity moles obtained hydrogen cell two sets equations consumption power determined chemical equations working conditions quito altitude msnm kpa atmospheric pressure temperature single cylinder engine powered hydrogen plus gasoline used getting real data engine power using mixtures air gasoline hydrogen theoretical power without increased real power without increased theoretical fuel consumption kwh addition less kwh actual consumption indicates manufacturer kwh
myelin oligodendrocyte glycoprotein mog member immunoglobulin super family myelin protein solely expressed outermost surface myelin sheaths oligodendrocyte membranes makes mog potential target cellular humoral immune responses inflammatory demyelinating diseases due late postnatal developmental expression mog important marker oligodendrocyte maturation discovered years ago one best studied autoantigens experimental autoimmune models multiple sclerosis human studies however yielded controversial results role mog especially mog antibodies abs biomarker improved detection methods using different expression systems detect abs patients samples meanwhile longer case using cell based assays recombinant full length conformationally intact mog several recent studies revealed mog abs found subset predominantly pediatric patients acute disseminated encephalomyelitis adem aquaporin aqp seronegative neuromyelitis optica spectrum disorders nmosd monophasic recurrent isolated optic neuritis transverse myelitis atypical methyl aspartate receptor encephalitis overlapping demyelinating syndromes whereas mog abs transiently observed monophasic diseases adem decline associated favorable outcome persistent multiphasic adem nmosd recurrent myelitis due distinct clinical features within diseases controversially disputed classify mog positive cases new disease entity neuropathologically presence mog abs characterized typical demyelination oligodendrocyte pathology associated abs complement however remains unclear whether mog abs mere inflammatory bystander effect truly pathogenetic article provides deeper insight recent developments clinical relevance mog abs role immunpathogenesis inflammatory demyelinating disorders
background psychopathy specific syndrome predicts future violent aggressive behavior adults studies youth adults demonstrated strong association early traumatic incidents later dissocial behavior moreover impact personality pathology emotional dysregulation aggressive violent behavior well established however studies addressed relationship early traumatization psychopathic traits adolescents method present study examined associations general dimensions personality pathology early traumatic experiences dimensions psychopathy male female adolescent detainees results analyses revealed associations physical abuse emotional dysregulation psychopathic traits delinquent boys delinquent girls conclusion hypothesized relationships trauma personality pathology could confirmed lifestyle antisocial core affective interpersonal facets psychopathy
objective non alcoholic fatty liver disease nafld claimed liver phenotype metabolic syndrome turn associated male hypogonadism assessed whether independent association nafld androgen deficiency could revealed men chronic spinal cord injury sci exhibit high prevalence biochemical androgen deficiency combination risk factors metabolic syndrome design fifty five consecutive men chronic sci admitted rehabilitation program underwent clinical biochemical evaluations liver ultrasonography results nafld diagnosed patients men nafld older exhibited significantly higher body mass index homeostatic model assessment insulin resistance triglycerides gammaglutamyl transpeptidase values lower total free testosterone levels engaged significantly poorer weekly leisure time physical activity ltpa multiple logistic regression analysis total free testosterone levels exhibited significant independent association nafld risk nafld increased indeed decrement total testosterone decrement free testosterone adjustment confounders men total testosterone adjustment confounders conclusion evidence independent association nafld low testosterone strongly reinforced demonstration men chronic sci spite many confounders peculiar population
spatial information dominant species submerged aquatic vegetation sav essential restoration projects eutrophic lakes especially eutrophic taihu lake china mapping distribution sav species challenging difficult using multispectral satellite remote sensing study proposed approach map distribution seven dominant species sav taihu lake approach involved information life histories seven sav species eight distribution maps sav february october life history information dominant sav species summarized literature field surveys eight distribution maps sav extracted eight ccd images february october based classification tree models overall classification accuracies sav greater finally spatial distribution sav species taihu mapped using multilayer erasing approach based validation overall classification accuracy seven species kappa suggests larger differences life histories species produce higher identification accuracies classification results show potamogeton malaianus widely distributed species taihu lake followed myriophyllum spicatum potamogeton maackianus potamogeton crispus elodea nuttallii ceratophyllum demersum vallisneria spiralis information useful planning shallow water habitat restoration projects elsevier rights reserved
end end delay measurement essential element deployment real time services networked systems traditional methods delay measurement based time domain analysis however efficient network scale complexity increase propose novel theoretical framework analyze end end delay distributions networked systems frequency domain use signal flow graph model delay distribution networked system prove end end delay distribution indeed inverse laplace transform transfer function signal flow graph two efficient methods cramer rule based method mason gain rule based method adopted obtain transfer function analyzing time responses transfer function obtain end end delay distribution based framework propose efficient method using dominant poles transfer function work bottleneck links network moreover use framework study network protocol performance theoretical analysis extensive evaluations show effectiveness proposed approach
increasing interest lean thinking traditional manufacturing engineering organizations recently non traditional white collar settings despite potential benefits organizations implemented lean facing problems sustainability study examine nexus lean thinking role hrm helping sustainability lean paper reports recent initiatives may leading changes ownership intellectual capital surrounding lean thinking new core expertise issue expertise lie study based interviews senior managers responsible lean management activity strategy within dozen large organizations traditional non traditional white collar organizations analyses expert opinions identify implicit strategies around lean implementation generate insights spectrum people related issues needed success lean adjustments needed architecture terms three core elements skills competencies needs implications practices essential role behaviours intended create amongst employees also examines expertise intellectual capital lie identifies structural solutions pursued
aims identify assess summarize available scientific evidence effectiveness interactive self management interventions glycemic control patient centered outcomes individuals poorly controlled type diabetes methods major english chinese electronic databases including medline embase cochrane central register controlled trials china national knowledge infrastructure wanfang data searched identify randomized controlled trials reported effectiveness interactive self management interventions individuals poorly controlled type diabetes glycated hemoglobin hbac mmol mol inception june data extraction risk bias assessment performed two reviewers independently meta analysis performed using review manager results total trials participants included meta analysis interactive self management interventions could beneficial effect individuals poorly controlled type diabetes reducing hbac mean difference improving diabetes knowledge standardized mean difference smd enhancing self efficacy smd reducing diabetes related distress smd self management interventions supported theory structured curriculum showed desirable results glycemic control behavioral change techniques including providing feedback performance problem solving action planning associated significant reduction hbac linking evidence action individuals poorly controlled type diabetes could benefit interactive self management interventions interventions targeting patients poorly controlled diabetes greatest risk developing complications prioritized findings indicate providing feedback performance problem solving action planning promising behavioral change techniques specifically individuals poor glycemic control
hardware loop simulation increasingly required design implementation testing control systems control loop components real hardware simulated usually real system software control system hardware study hardware loop simulation used test performance interval type fuzzy proportional derivative itf controller itf controller implemented using low cost microcontroller controlling uncertain nonlinear inverted pendulum itf controller able handle system uncertainties better type counterparts results itf controller compared tif controller experimental results show itf controller made significantly improved performance wide range structural uncertainties effect external disturbances elsevier inc rights reserved
objectiveto evaluate efficacy safety optimum dose daily oxybutynin patch overactive bladder methodsa randomized double blind trial conducted patients overactive bladder symptoms weeks received oxybutynin patch placebo daily weeks primary endpoint change daily frequency micturition baseline end study resultsa total patients randomized placebo group oxybutynin patch group oxybutynin patch group frequency micturition meanstandard deviation decreased placebo group group group compared placebo group micturition decreased significantly groups test respectively decrease similar oxybutynin groups oxybutynin groups showed significant improvement urgency urge incontinence incontinence nocturia mean voided volume five six domains king health questionnaire dry mouth noted group group constipation comparable oxybutynin groups placebo group application site reactions less frequent group group conclusion efficacy oxybutynin patch confirmed optimum dose japanese patients overactive bladder
students mathematics learning disabilities mld weak understanding fraction concepts skills foundations algebra students might benefit computer assisted instruction utilizes evidence based instructional components cognitive strategies feedback virtual manipulatives pilot study using multiple baseline design multiple probes study investigated effects fun fraction multi component computer assisted instructional program word problem solving fractions abilities three middle school students mld mixed findings observed word problem solving performance baseline intervention phase students received instruction fun fraction percentage non overlapping data ranged limitations suggestions future research educational implications discussed
hybrid powertrain provides driving torque based upon vehicle acceleration pedal position due slow response internal combustion engine electric motor often provide additional torque transient vehicle operations cold start operations available battery power significantly reduced due cold temperatures due starting delay engine battery provide power level beyond normal operation limit electrical motor meet torque demand would dramatically shorten battery life however desired powertrain torque predicted engine could started early predicted future powertrain power higher battery normal operational range hence duration battery operated normal operational range could significantly reduced leading extended battery life makes predicting multistep future torque demand based upon current past torque demand data important subject amid many existing studies research studies focused subject paper proposes adaptive recursive prediction algorithm estimate future desired powertrain torque compares performance proposed algorithm two existing prediction algorithms step step fixed gain algorithms three prediction algorithms studied federal test procedure ftp another four typical driving cycles simulation results show adaptive recursive prediction algorithm reduces prediction error significantly maximum prediction error addition reduced computational load makes feasible real time implementation introduced weighting factors past current data key improve prediction accuracy avoid prediction calculation underflow addition due online update regression gain proposed algorithm also robust driving behavior variations
botulinum toxin bont become important therapeutic tool management refractory overactive bladder oab last decade growing numbers patients receiving repeat injections outcomes begun reported large high quality cohorts article reviews current evidence medium long term use bont adults idiopathic detrusor overactivity ido receiving repeat injections find medium term outcomes encouraging long term outcomes extensively reported high quality evidence efficacy following first injection persists across multiple treatment cycles additional safety concerns repeat injections six treatment cycles however need data confirm efficacy safety bont beyond follow period current literature
paper propose client server based framework alleviates dissemination xss worms osn framework initially creates views corresponding retrieved request server side views indicate part generated web page server accessed user depending generated access control list acl secondly javascript attack vectors retrieved http response referring blacklist repository attack vectors finally injection sanitization primitives done client side place extracted javascript attack vectors framework perform sanitization attack vectors strictly context aware manner experimental testing framework performed two platforms open source osn based web applications observed detection rate javascript attack vectors effective acceptable compared existing xss defensive methodologies proposed framework optimized method auto context aware sanitization contrast existing approaches hence incurs low acceptable performance overhead
development liquid cooled integrated circuits ics using silicon microchannels study heat transfer thermal modeling liquid cooled heat sinks gained interest last five years consequence several methodologies thermally aware design liquid cooled ics multiprocessor system chips mpsocs appeared literature key component methodologies fast accurate thermal modeling technique easily interfaced design optimization tools conventional fully numerical techniques finite element methods render enable easy interfacing design tools order complexity large fast simulations context present new semi analytical representation heat flow forced convective cooling inside microchannels continuous along direction coolant flow model based well known analogy heat conduction electrical conduction introduces distributed electrical parameters dimension considered continuous resulting state space representation heat transfer problem steady state transient semi analytical models presented proposed semi analytical model shown closed form solution certain cases encountered practical design problems accuracy model validated state art thermal modeling frameworks errors speed proposed modeling framework
introduction endocrine pancreas plays pivotal role glucose metabolism regards morphogenesis islets langerhans conflicting data regarding timing appearance cells proportion arrangement cells within islets present work baseline study conducted indian subcontinent histogenesis islets langerhans studied also observed expression anti insulin antibody islets different gestational ages methods ten aborted fetal specimens pancreas gestational ages weeks procured department obstetrics gynaecology lnjp hospital new delhi fetuses fixed formalin serial sections stained haematoxylin eosin sections processed immunocytochemistry specific marker cell anti insulin antibody results cells islets arise lining epithelium tubules cells contain insulin week seen immunostaining small capillaries seen enclosed islets weeks arrangement cells different islets variable formation islets continues throughout fetal life discussion study reaffirms endocrine pancreas begins differentiate early fetal life growth maturation islets associated coordinated vascular development week intrauterine life fetal pancreas attains sufficient morphological maturity fulfil hormonal requirements growing fetus copyright anatomical society india published reed elsevier india pvt ltd rights reserved
objectives aim study evaluate efficacy sacral neuromodulation patients prior stress urinary incontinence sui pelvic organ prolapse pop surgery methods women prospective neuromodulation database evaluated patients history prior sui pop surgery compared without medical records baseline reviewed primary outcome defined moderate marked improvement global response assessment gra months secondary outcomes measured using bladder diaries overactive bladder symptom severity oabq health related quality life hrqol data analyzed pearson chi test fisher exact test wilcoxon rank sum test repeated measures analyses results subjects prior sui pop surgery patients sui pop surgery prior hysterectomies months difference groups gra outcomes bladder diary groups improvement median voids per hours urgency severity urge incontinence years gra fewer patients sui pop group treatment responders months urinary urgency group moderately markedly improved months higher proportion reported still leaking urine months similar proportions group reported moderate marked improvement leaking satisfaction similar groups oabq hrqol scores improved difference groups conclusion sacral neuromodulation improves bladder symptoms women prior sui pop surgery response may slightly less prior surgery due underlying bladder pelvic floor issues
lynch syndrome inflammatory bowel diseases ibd associated increased risk colorectal cancer crc however clear whether risk crc even higher patients combination lynch syndrome ibd investigated risk crc subgroup establishing lynch syndrome cohort radboud university medical center nijmegen netherlands academic medical center amsterdam netherlands patients heterozygous germline mutations mlh msh epcam deletion mediated msh methylation msh pms tested treated included patients developed ibd identified linkage cohort dutch nationwide pathology registry palga subsequently compared risk crc lynch syndrome patients ibd without ibd patients lynch syndrome developed ibd patients lynch syndrome ibd significantly younger median age patients lynch syndrome without ibd median age nevertheless similar proportion patients group developed crc patients lynch syndrome ibd compared patients lynch syndrome without ibd patients lynch syndrome ibd developed crc younger age median age patients lynch syndrome without ibd median age however cumulative incidence crc similar groups patients lynch syndrome ibd developed crc ulcerative colitis producing higher cumulative incidence crc ibd subgroup conclusion patients lynch syndrome ibd develop crc risk younger age patients without ibd patients ulcerative colitis especially high risk
new fast computational structure identical forward backward modified discrete cosine sine transform mdct mdst computation described result systematic construction fast algorithm efficient implementation complete time domain aliasing cancellation tdac analysis synthesis mdct mdst filter banks shown computational structure used encoder decoder thus significantly reducing design time resources corresponding generalized signal flow graph regular defines new sparse matrix factorizations discrete cosine transform type dct mdct mdst matrices identical fast mdct computational structure provides efficient implementation mdct mpeg layer iii audio coding dolby labs codec steps derive computational structure described detail put perspective comprehensive list references classified categories provided covering new research results achieved time period theoretical practical developments tdac analysis synthesis mdct mdst filter banks general mathematical symmetry special properties fast mdct mdst algorithms efficient software hardware implementations mdct crown copyright published elsevier rights reserved
background success treatment prevention tasp control hiv relies uptake testing across priority population groups innovative strategies including rapid hiv testing rht community outreach settings engaging peer service providers requiring disclosure sexual history designed increase access paper reports implementation rapid community based testing program queensland australia employs strategies increase access testing methods service data including client registration forms satisfaction survey clients attending rapid august july analysed results people attended rapid receive free hiv test majority urban based gay men first time testers participants eligible access medicare australia universal health care scheme conclusions rapid evidence based strategies appear facilitate access hiv testing particularly among never tested however implications ongoing treatment care people ineligible medicare test positive hiv warrants careful consideration
derive four laws relating absorptivity emissivity thermal emitters unlike original kirchhoff radiation law derivations derivations include diffraction valid also small objects also cover nonreciprocal objects proofs exploit two recent approaches first express fields terms mode converter basis sets beams sets uniquely established linear optical object give orthogonal input beams coupled one one orthogonal output beams second consider thought experiments using universal linear optical machines allow couple appropriate beams black bodies two laws regarded rigorous extensions previously known laws one gives modal version radiation law reciprocal objects absorptivity input beam equals emissivity backward phase conjugated version beam another gives overall equality sums emissivities absorptivities object including nonreciprocal ones two laws valid reciprocal nonreciprocal objects quite different previous relations one shows universal equivalence absorptivity mode converter input beam emissivity corresponding scattered output beam gives unexpected equivalences absorptivity emissivity broad classes beams additionally prove orthogonal mode converter sets input output beams ones maximize absorptivities emissivities respectively giving beams surprising additional physical meaning
objective children clinically diagnosed juvenile psoriatic arthritis jpsa enrolled childhood arthritis rheumatology research alliance carra registry carra jpsa classified according pediatric international league associations rheumatology ilar adult criteria classification criteria psoriatic arthritis caspar data demographic clinical features baseline year followup analyzed compared methods cross sectional analysis performed carra jpsa patients enrolled may december stratified according age disease onset yrs features patients fulfilling ilar caspar criteria compared baseline followup using chi square fisher exact mann whitney mcnemar wilcoxon signed rank tests appropriate results among children enrolled carra jpsa symptom onset years age male predominance high prevalence enthesitis followup statistically significant improvements reported arthritis dactylitis enthesitis psoriasis sacroiliitis nail pitting health questionnaire scores patients fulfilled ilar criteria jpsa fifty two patients whose disease fulfilled caspar criteria included jpsa cohort manifested enthesitis sacroiliitis inflammatory bowel disease uveitis less psoriasis conclusion data support division patients jpsa clinical subgroups according age disease onset improvement objective findings correlate changes scores pediatric rheumatologists currently diagnose jpsa children whose disease manifestations meet caspar criteria unification adult pediatric psa classification criteria warrants consideration
parents children burns experience range psychological reactions symptoms parents health known impact children health far little research potential mechanisms maintain parents symptoms aim investigate parental injury related fear avoidance associations injury severity health measures parents children aged years sustained burns years previously completed questionnaires fear avoidance posttraumatic stress health child analyses showed average level fear avoidance low positively associated measures injury severity parents symptoms posttraumatic stress negatively associated parents ratings child health two separate multiple regressions parents symptoms ptsd child health dependent variables fear avoidance made largest contribution models injury severity non significant results related comorbid conditions child scarring parent related socio demographic variables summary injury related fear avoidance likely among parents whose children sustain severe burns turn fear avoidance contributes significantly parents symptoms ptsd poorer health ratings regarding child irrespective injury severity child comorbidity elsevier ltd isbi rights reserved
smart homes smart grids become today efficient approach face problem energy shortage example egypt facing huge problem fuel shortage power stations fail supply power millions electricity users result power station cuts power specific district certain time without considering unfair distribution power home energy management hem system integrates concept smart homes smart grids full data scheme customer load behavior accessed energy management center data processed way ensure fair power share users work proposes prototype remote control system deals problem implementing web based communication link power manager heavy loads customer prototype system completely designed built tested laboratory early results confirm expected performance
first time potential noble metal free iron based photosensitizers photocatalytic water reduction using homo heteroleptic carbene complexes proven development facile synthesis route carbene complexes delineated complexes investigated vis fluorescence spectroscopy dft calculations cyclic voltammetry ray absorption spectroscopy catalytic performance compared established noble metal containing photosensitizers ppy bpy hppy phenylpyridine bpy bipyridine
background simulation become accepted method increase confidence among healthcare professionals felt simulation might similar benefits parents babies discharged neonatal intensive care unit purpose developed neonatal home environment learning program promote parental confidence anticipation infant discharge neonatal intensive care unit methods evaluation study conducted mother father dyads participant recorded self perceived confidence score simulation experience participants also completed program evaluation participated debriefing session confidence scores pre postsimulation evaluation scores analyzed descriptive statistics responses debriefing sessions analyzed using descriptive phenomenology results parents rated simulation experience highly debriefings parents shared simulation made feel prepared two themes emerged debriefing data alone different expected feeling confident clinical implications simulation experience parents helps ensure positive transition home safe effective care discharge infant
study tested predictive value attentional bias emotion recognition automatic associations response inhibition assessment clinic violent incidents sixty nine male forensic patients participated completed emotional stroop measure attentional bias threat aggression single target implicit association task assess automatic associations graded emotional recognition task measure emotion recognition affective nogo measure response inhibition violent incidents derived patient files scored severity level predictive value level psychopathy tested psychopathy checklist revised pcl generalized linear mixed model analyses showed increased attention towards threat aggression difficulty recognizing sad faces factor pcl predicted sum violent incidents specifically verbal aggression predicted increased attention towards threat aggression difficulty recognize sad happy faces pcl factor physical aggression decreased response inhibition higher pcl factor lower pcl factor scores aggression property difficulty recognizing angry faces findings indicate cognitive tasks could valuable predicting aggression thereby extending current knowledge dynamic factors predicting aggressive behavior forensic patients elsevier ireland ltd rights reserved
gonadotropin releasing hormone gnrh neurons originate nasal placode migrate brain prenatal development within brain cells become integral components hypothalamic pituitary gonadal axis essential reproductive function disruption system causes hypogonadotropic hypogonadism associated anosmia clinically defined kallman syndrome recent work examining developing nasal region shed new light cellular composition cell interactions molecular cues responsible development system different species review discusses developmental aspects animal models current advancements understanding pathologies affecting gnrh addition discuss development neural crest derivatives glia olfactory system craniofacial structures control gnrh development reproductive function published elsevier inc
background aims endoscopic balloon dilation ebd serve alternative surgery intestinal stenosis associated crohn disease however controversy regarding efficacy safety ebd sought determine therapeutic efficacy safety ebd intestinal stenosis materials methods patients accompanied intestinal stenosis underwent ebd patients examined retrospectively terms scope passage rate surgery free rate whether observation distal intestinal tract influenced therapeutic strategy results overall scope passage surgery free rates respectively statistically significant differences site dilated intestinal tract among groups patients inflammation distal intestinal tract alone ebd accounted rate dilation time dilation months conclusion ebd associated favorable short term long term outcomes good safety observation distal intestinal tract influenced decision making process therapeutic strategies results study suggest ebd may allow postponement even avoidance surgery enabling intestinal dilation also evaluation mucosal healing performed thus ebd considered effective alternative treatment intestinal stenotic lesions patients
paper efficient secure multi proxy multi blind signature scheme proposed based controlled quantum teleportation genuine six qubit entangled state functions quantum channel scheme uses physical characteristics quantum mechanics guarantee unforgeability undeniability blindness unconditional security
poor locality natural property graph data structures causes enormous amount network traffic large scale distributed graph processing systems moreover data transmission network one expensive operations distributed system therefore reduction network usage highly required new graph computational model paper increasing degree machine independency considered key factor network traffic reduction proposed system benefits three layered computational model perfectly leverage power local information much possible moreover model simultaneously takes advantages message based shared state communication paradigms vertices read update values others lowest layer directly must send messages layers use memorization techniques proposed model introduces new kind intelligence encouraging effects removing useless communications distinctive results experiments confirm significant improvements proposed model relation previous systems like pregel gps blogel well expregel results also show overhead making processes independent along intelligent negligible comparison cost additional network communications
segmentation based image analysis techniques routinely employed quantitative analysis complex microstructures containing two phases primary advantage approaches spatial information distribution phases retained enabling subjective judgements quality segmentation subsequent analysis process downside computing micrograph segmentations data morphologically complex microstructures gathered error prone detectors challenging special care taken artifacts segmentation make subsequent analysis conclusions uncertain paper demonstrate using two phase nickel base superalloy microstructure model system new methodology analysis precipitate shapes using segmentation free approach based histogram oriented gradients feature descriptor classic tool image analysis benefits methodology analysis microstructure two three dimensions demonstrated
paper novel structure compact uwb slot antenna design optimization procedure presented order achieve sufficient number degrees freedom necessary obtain considerable size reduction rate slot parameterized using spline curves antenna dimensions simultaneously adjusted using numerical optimization procedures fundamental bottleneck high cost electromagnetic simulation model structure includes reliability sma connector another problem large number geometry parameters nineteen sake computational efficiency optimization process therefore performed using variable fidelity simulations surrogate assisted algorithms optimization process oriented towards explicit reduction antenna size leads compact footprint well acceptable matching within entire uwb band simulation results validated using physical measurements fabricated antenna prototype
backgroundadvanced glycation end products ages interaction receptor ages rage studied role pathogenesis complications type diabetes decreased concentrations soluble rage srage reported acute autoimmune inflammation set analyze changes srage concentration preclinical diabetes children seroconverting islet autoantibody positivity methodswe measured serum concentrations srage children progressed clinical disease children turned positive least diabetes associated autoantibodies remained nondiabetic analyzed srage seroconversion first autoantibody positive sample annually thereafter diagnosis type diabetes end follow resultsboth groups similar srage seroconversion subsequently srage concentrations lower progressors progressors significantly higher srage concentrations seroconversion nonprogressors experience similar decrease srage concentrations remained stable seroconversion groups conclusionsthese data indicate srage may involved initiation beta cell autoimmunity progression beta cell autoimmunity clinical disease
mixed fungal infection acquired echinocandin resistance candida spp remain infrequent study reported case patient hospitalized tuberculosis experienced multiple infections due three common candida species albicans glabrata tropicalis furthermore consecutive isolates blood cultures heart valve found resistant azoles tropicalis echinocandin either novel tropicalis previously described albicans missense mutations fks gene
thylakoids complete sets photosynthetic membrane proteins contained behave soft nanoparticles tens sizes thus separated thylakoid extracts spinach chloroplasts densely organized film either insulating polyethyleneimine pei conducting polyaniline pani molecularly controlled layer layer lbl assembly resulting nanostructured composite films demonstrated photoelectrochemical activities thylakoids whose stabilities significantly improved charge balanced lbl multilayers compared one randomly deposited film solution thylakoid lbl films continuously generated photochemical electrons longer dichlorophenolindophenol dcpip mediated photosynthetic energy conversion cycle photoactivities thylakoid moiety slowly decreased open circuit potential measurements throughout photosynthetic redox cycles incomplete photofunctional groups thylakoid films originated biotic system photofuctional thylakoids exceptionally well preserved charge balanced artificial structures developed thylakoid lbl film shown inherent biocompatibility upon neural cell attachment differentiation tests essential qualities emerging human friendly electronic applications disposable electronics artificial retina implantable neural interfacing meditronics well cell free photosynthetic production elsevier rights reserved
study hycole weaned rabbits days old randomly divided four groups rabbits studied throughout day experimentation period order determine impact dietary supplementation herbs composed dry ground lythrum salicaria leaves cunirel commercial herb mixture containing main ingredient performance digestibility health meat quality basal diet given control group significant differences found performance rabbits group selected evaluation regarding apparent digestibility rabbits fed control diet diet low level higher level digestibility animals supplemented high levels respectively ether extract digestibility lower treatment group addition compared control group respectively slaughter process performed day old rabbits study carcass characteristics meat quality blood parameters caecal contents gut histology total leukocyte counts control animals lower rabbits fed respectively caecal fermentation caecal contents rabbits fed showed higher concentrations total volatile fatty acid vfa dry matter acetic acid lower ammonia levels compared control group pcr denaturing gradient gel electrophoresis analyses performed evaluate microbial community hard faeces collected days whereas caecal contents taken slaughtering results demonstrated treatment groups similarity microbial communities higher compared control group moreover age shown influence microbiota diversity conclusion results study indicated supplementation rabbit diets leads increase total white blood cells total vfa acetic acid concentration decrease ammonia levels well digestibility high level supplemented without causing adverse effects parameters
countercurrent flow limitation ccfl experimentally investigated downscaled collider facility pipe diameter using air water atmospheric pressure previous investigations provided knowledge onset ccfl mechanisms current article ccfl characteristics collider facility measured discussed along time averaged distributions air water interface selected matrix liquid gas velocities article demonstrates time averaged interface useful method identify ccfl characteristics quasi stationary flow conditions eliminating variations appears single images showing essential comparative flow features degree restriction bend extension intensity two phase mixing zones average water level within horizontal part steam generator consequently making possible compare interface distributions obtained different investigations distributions also beneficial cfd validations ccfl instant chaotic gas liquid interface impossible reproduce cfd simulations current study shows final ccfl characteristics curve corresponding ccfl correlation depends upon covered measuring range water delivery also shows hydraulic diameter sufficiently larger order obtain ccfl characteristics comparable scale data namely uptf data finally study shows change flow condition inside hot leg related water air inlet velocities also dependent upon existent interface distribution within hot leg several ccfl cases identical inlet flow conditions exist different interface distribution pressure difference last result special importance investigation phenomenon sbloca accidents since entire phenomenon driven pressure difference steam generator reactor vessel well gravity result show also ccfl characteristics investigated using codes interface distribution within hot leg sbloca accident depend upon flow history previous interface distribution current investigations support effort provide knowledge ccfl order extrapolate results obtained downscaled models scale elsevier ltd rights reserved
paper stable robust filter proposed structural identification filter resolves instability problems traditional extended kalman filter ekf instead hoc assignment noise covariance matrices ekf proposed stable robust extended kalman filter srekf provides real time updating noise parameters resolves well known instability problem ekf due improper assignment noise covariance matrices furthermore proposed srekf capable removing abnormal data points real time manner result parametric identification results reliable fewer fluctuations proposed approach applied structural damage detection degrading linear nonlinear structures comparison plain ekf utilizing highly contaminated response measurements turns estimation error state vector structural parameters lower ekf one two orders magnitude respectively american society civil engineers
objectives describe incidence determinants survival patients nasopharyngeal lymphoma npl using surveillance epidemiology end results seer database study design retrospective cohort study using national database methods seer registry used calculate survival trends patients npl patient data analyzed respect histopathology age sex race histologic subtype ann arbor stage whether radiation therapy given overall survival disease specific survival dss calculated results total cases npl identified cohort composed males mean age diagnosis years median years cell non hodgkin lymphomas nhls accounted cases natural killer cell lymphomas comprising cases total patients received radiation therapy years respectively multivariate analysis advanced age cell nhl histologic subtype associated worse dss radiation therapy associated improved dss conclusion exception cell nhl subtypes npl associated fair prognosis younger age low ann arbor stage radiation therapy independent positive prognosticators survival
smart materials physical properties changed controlled external stimuli electric magnetic fields temperature stress shape size color among properties changed smart material interfaces physical interfaces utilize smart materials sense environment display responses changing physical properties workshop aims stimulating research development interfaces make novel use smart materials provides platform state art design smart material interfaces
purpose melanopsin expressing intrinsically photosensitive retinal ganglion cells iprgc input multiple brain regions including pupil control circadian rhythms sleep mood regulation measured iprgc function relationship sleep quality depression patients advanced amd methods melanopsin mediated post illumination pupil response pipr measured patients advanced amd age years healthy controls age years sleep quality efficiency assessed using pittsburgh sleep quality index psqi risk depression determined using center epidemiologic studies depression questionnaire results group amd showed significantly reduced pupil constrictions pipr amplitudes global sleep scores higher levels depression control group significant correlation pipr amplitude global sleep score amd group amplitude pipr significantly correlated sleep efficiency regression sleep quality amd group correlation pipr depression scores conclusions intrinsically photosensitive rgc dysfunction advanced amd contributes observed reduction sleep efficiency correlation melanopsin mediated pipr sleep may indicate reduced photic input suprachiasmatic nucleus ventrolateral preoptic area due iprgc dysfunction amd
objectives objectives study describe compare treatment persistence first second line subcutaneous tumor necrosis factor alpha inhibitors tnfis patients ankylosing spondylitis psoriatic arthritis psa rheumatoid arthritis collectively immune mediated rheumatic disease sweden estimate contrast health care costs two groups methods patients initiated first second tnfi may december identified prescribed drug register persistence estimated using survival analysis costs comprised specialized outpatient care inpatient care medication persistence analysis stratified immune mediated rheumatic disease diagnosis results total patients treated first patients treated second tnfi identified baseline characteristics differed two groups therefore propensity score matching analysis implemented second line patients matched first line patients four cohort pairs psa diagnoses combined generated patients treated first tnfi statistically significant higher persistence patients treated second tnfi psa diagnoses combined patients treated second tnfi incurred higher costs patients treated first tnfi conclusion overall persistence first tnfi higher persistence second tnfi furthermore second tnfi associated higher costs first tnfi therefore prescribing tnfi best long term persistence first may beneficial
concept transformation molecules materials well established field chemical vapor deposition cvd atomic layer deposition ald however materials scientists always lookout new materials enhanced functionalities eventual application devices new materials become integral part modern day technology especially field microelectronics optoelectronics importance cvd ald processes high throughput coating complex device geometries well recognized applications since underlying precursor chemistry one main parameters dictate processes still scope exploratory research terms precursor design development suits demands advanced technologies wide range precursors used realize specific class materials trend recently driven reduced thermal budget needed especially components employed microelectronics optoelectronics chronological developments precursors cvd ald point designer precursors set play major role field materials engineering desirable growth conditions could achieved proper selection compounds may stem available class metal complexes even engineered compounds review article concept utilizing old chemistries new cvd ald applications highlighted focussing representative functional materials namely group rare earth oxides recent results precursor development carried inorganic materials chemistry research group bochum germany summarized published elsevier
monitoring operational efficiency construction equipment offers great opportunities enhance productivity also environmental performance construction operations however existing enabling technologies still suffer lack economic feasibility well technological compatibility equipment fleets outdated consist diverse manufacturers models context paper examines feasibility measuring operational efficiency equipment using low cost accelerometers acceleration data three axes collected real world operation excavators performed various duty cycles multiple features calculated acceleration data several classifiers using features tested classify equipment operation engine idling working modes accuracy obtained classification excavators operation result demonstrated application low cost accelerometers potential provide robust system automatically measure operational efficiency construction equipment without connection legacy engine system
osteoporosis self assessment tool osta predicts risk osteoporosis individual simple calculation based tool age used measuring bone mineral density bmd however osta influenced ethnicity studied performance osta index screening tool osteoporosis community dwelling north indian men age subject underwent detailed clinical dietary anthropometric biochemical assessment bone density measurement using dual energy ray absorptiometry per world health organization criteria osteoporosis osteopenia normal bmd observed respectively osta index ranged ost index predicted osteoporosis sensitivity specificity area curve receiver operating characteristic curve osta index effective screening tool measuring bmd elderly indian men used primary care physicians
nogo variants auditory event related potentials shown promising clinical researches however prior wider application important evaluate potential modulating factors aimed evaluate gender effect behavioral electrophysiological responses auditory equiprobable nogo task auditory equal probability nogo paradigm two types stimuli presented healthy subjects females males age years eeg recording behavioral performance latency amplitude waves nogo conditions evaluated compared genders response times differ genders however females less accurate task also exhibited slower nogo conditions higher amplitudes results suggest females require longer times monitoring response conflict outcome inhibition nogo neural resources longer processing times motor response execution research provides evidence gender factor important nogo studies employing auditory equiprobable paradigm
impact women education fertility interest researchers particularly china however studies provided well founded assessments women education workforce experience birth control policy jointly affect fertility china study conducted guangdong province aimed analyze three factors influenced timing births affected women different stages reproductive lives used census data guangdong province make cross sectional age specific comparisons examine effects women education workforce participation fertility outcomes china one child policy found circumstances low fertility women tend children greater educational attainment impact women education workforce experience fertility varied across age groups effect education showing bimodal curve peaking years years workforce experience effect years fertility time squeeze effect educational attainment relatively small effect workforce participation larger important effect birth control policy implementation results suggest educational attainment workforce experience substantial effect women fertility tradeoff unavoidable china birth control policy adjustment considered planning future services accommodate anticipated increases birth rate attention directed causal mechanism women preference selection effects behind factors analyzed study
ability unobtrusively measure velocity aquatic environment fundamental challenge engineers sport scientists past video systems first choice monitor athletes training acceptance small inertial sensors new ways investigating athletes movements arisen small systems light easy use hinder athlete training allowing easy tracking training improvements research used self developed low cost inertial sensor system attached lower back record acceleration swimmers performing sub surface wall push offs recorded data downloaded matlab data analysis using seven swimmers wall push velocity three different efforts analysed compared tethered cable velocity meter criterion measure using regression bland altman analysis maximum velocity determined accelerometer unit linearly related benchmark criteria biomechanical technique determination maximum glide velocity acceleration data verified authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
benefit electronic cigarettes cigarettes smoking cessation remains controversial recently cigarettes gaining popularity japan without evidence efficacy quitting cigarettes conducted online survey collect information tobacco use difficulties smoking cessation socio demographic factors health related factors japan among total participants eligible persons aged years smoked within previous five years analyzed assess relationship outcome smoking cessation quitting methods used including cigarettes smoking cessation therapy unassisted cigarette use negatively associated smoking cessation odds ratio confidence interval adjusting gender age health related factors quitting methods conversely smoking cessation therapy varenicline significantly associated smoking cessation model effective smoking cessation cigarette use appears low efficacy among smokers japan allowing fact study limited cross sectional design follow studies needed assess prospective association cigarette use smoking cessation
system developed fulfill entire coupled multiphysics analysis cycle design analysis complex fusion reactor components provides advanced modeling capability converting computer aided design geometries monte carlo geometries employing constructive solid geometries unstructured meshes also realizes generic multiphysics coupling neutronics computational fluid dynamics finite element thermal structural analyses system seamless extensible generic system intensively verified fusion applications
link education crime topic requires special attention respect converging influence individual social environmental factors article investigate educational pathways followed students higher education program formerly incarcerated individuals large state university northeastern united states specifically explore extent postincarceration educational experiences served hook change also related impediments tied street influences financial constraints stigma academic social development data collected sample current former students program participated face face interview higher education program played key role propelling desistance process research participants article discuss personal agency sustained participation higher education post release implications future research crime avoidance
web based labs key tools distance education help illustrate scientific phenomena require costly difficult assemble equipment easy java simulations ejs authoring tool speeds creation kind labs excellent proof ejs potential open source physics osp repository hosts hundreds free ejs labs learning management systems moodle provide social contexts students interact work described paper looks synergy tools ejs moodle supporting deployment ejs labs moodle thus enriching social features chat forums video conference test approach authors created ball beam lab helps students automatic control engineering train different advanced techniques robust fuzzy reset control compare performance relation conventional proportional integral derivative control
study investigated visual false memories posttraumatic stress disorder ptsd scenic false memory paradigm sfm hauschildt peters jelinek moritz administered male iranian military personnel participated iran iraq war diagnosed without ptsd sample healthy male non trauma exposed controls trauma exposed participants recalled recognized significantly lower percentage hits significantly greater percentage false memories trauma related non trauma related video scenes non trauma exposed controls among trauma exposed participants without ptsd differ significantly terms percentage hits false memories recalled sfm ptsd found recognize significantly fewer hits trauma related non trauma related videos without ptsd ptsd also recognized significantly false memories trauma video scene non ptsd group findings suggest trauma exposure particular ptsd may greater susceptibility visual false memory
aim although physical activity brings range lifelong health benefits may also lead injuries pose significant threat health particularly noticeable people involved professional sports sport related injuries commonly occur associated intense exercise aims improve physical fitness article attempts determine incidence sports injuries reported plus league volleyball players well identify common types causes methods research project involved plus league volleyball players aged average age method diagnostic survey applied collect empirical data means questionnaire developed authors researchers results statistically analysed verified analysis variance anova chi test significance level critical value results respondents suffered least one sport related injury total injuries occurred average injuries per one volleyball player common sports injuries involved ankle talocrural joint injuries knee lower leg muscles interphalangeal articulations fingers well shoulder joint half injuries occurred twice three times volleyball players commonly sustain injuries contact opposing player competition sport specific injuries may also occur due exhaustion lack rest undertreated injuries conclusion common volleyball related injuries primarily talocrural joint hand shoulder injuries common types injuries affect volleyball players include muscles joints ligaments injuries sprains strains well bruises injuries caused exhaustion contact opposing player competition fatigue incidence sport related injuries seems influenced factors somatic features jumping parameters length professional volleyball career
despite continuous interest multiple sclerosis research still lack neuroprotective strategies main focus remained modulating immune response performed depth analysis neurodegeneration experimental autoimmune encephalomyelitis eae vitro studies regarding effect well established type calcium channel antagonist nimodipine nimodipine treatment attenuated clinical eae spinal cord degeneration promoted remyelination surprisingly observed calcium channel independent effects microglia resulting apoptosis effects cell type specific irrespective microglia polarization apoptosis accompanied decreased levels nitric oxide inducible synthase inos cell culture well decreased inos reactive oxygen species levels eae addition increased numbers olig apc oligodendrocytes detected overall nimodipine application seems generate favorable environment regenerative processes therefore could treatment option combines features immunomodulation beneficial effects neuroregeneration
climate change extreme heat events increasing important understand vulnerable heat associated morbidity determined association hospitalizations natural causes cardiovascular respiratory renal diseases diabetes mellitus acute myocardial infarction michigan usa different intensities durations assessed confounding ozone individual characteristics health insurance payer proxy income modified associations obtained michigan inpatient database national climatic data center environmental protection agency ozone data may september three michigan counties employed case crossover design modeled indicator temperature percentile thresholds days examined effect modification patient age race sex health insurance payer pooled county results among non whites pooled odds ratio hospitalization percentile threshold non days renal diseases increased increasing intensity null among whites observed null association cardiovascular hospitalization percentile threshold associated myocardial infarction hospitalizations confounding ozone minimal associated hospitalizations renal disease among non whites information vulnerability heat associated morbidity helps characterize public health burden target interventions including patient education
paper focuses dynamic behavior magnetorheological fluid undergoing unsteady oscillatory shear presence applied magnetic field problem studied nonlinear mechanical system perspective using tools analysis phase space frequency response neural networks parameters identification purpose several numerical simulations performed compute motion magnetic rigid spheres suspendend newtonian carrier liquid particles neutrally buoyant interact hydrodynamically magnetically throughout process dynamic simulation apply external magnetic field together oscillatory shear two deterministic mechanisms compete align particles preferential direction nonlinearities introduced system due particle particle interaction intensity non deterministic mechanisms regulated two physical parameters appear present formulation numerical simulations based sophisticated technique ewald sums compute convergent hydrodynamic magnetic interactions numerical research code developed authors used purpose code accurate computationally efficient present work intends show several tools otherwise thought mostly applied dynamics nonlinear systems used explore physical behavior wet suspensions fluid mechanics moreover several details micromechanics complex materials captured physically interpreted use proposed tools elsevier rights reserved
objective evaluate effect introduction treatment sterilization guidelines number avoidable injections sterility needles syringes methods randomly selected health units mwanza region tanzania visited factors determined might contribute hiv transmission injections workshop senior health workers region findings presented treatment sterilization guidelines developed thereafter seminars held health centre region four months intervention data collected health facilities order assess changes prescribing practices sterilization procedures sterility needles syringes results knowledge indications injections improved markedly paramedical staff proportion outpatients receiving injection dropped proportion patients receiving avoidable injection dropped procedures sterilization keeping sterilized equipment administration injections improved smaller proportion sterilized needles syringes tended contaminated dispensaries reduction significant conclusion considerable improvement knowledge prescription practices sterility procedures observed dispensary level carrying training programme
study design retrospective cohort study prospectively collected surgical database objective aim study investigate effect smoking day morbidity mortality patients undergoing surgery adult spinal deformity asd summary background data conflicting evidence regarding impact smoking short term outcomes spinal fusion methods retrospective review prospectively collected american college surgeons national surgical quality improvement database performed years patients underwent spinal fusion asd identified thirty day morbidity mortality compared current smokers nonsmokers independent effect smoking investigated via multivariate logistic regression analysis results total patients met inclusion criteria included study patients smokers nonsmokers proportion smokers developed least one complication versus nonsmokers major complication rates including day mortality smokers nonsmokers current smoking status associated increased odds developing complication odds ratio confidence interval major complications multivariate analysis conclusion smoking associated higher day complications mortality corrective surgery asd study however given negative effects smoking overall health spine surgery outcomes long term smoking cessation spinal fusion still recommended
dural venous sinus thrombosis dvst rare cause stroke typically affects young women importance identifying pre disposing factors lead venous stasis lies foundation understanding etiology pathophysiology clinical presentation precise therapeutic role interventional therapies fully understood though current data suggest potential applications aim study perform systematic review meta analysis evaluate utility short term day survival endovascular therapy patients dvst standard prisma guidelines followed data sources included pubmed keywords phrases also incorporated mesh search yield articles indexed medline year period rcts observational cohort studies administrative registries comparing reporting dvst included sixty six studies met inclusion criteria articles investigating treatment summation patients eligible data extraction included review treatment modalities total patients included statistical analysis patients included received endovascular intervention direct thrombolysis mechanical thrombectomy patients documented neurologic decline prompted endovascular intervention patients endovascular interventions started failed systemic anticoagulation patients reported intracranial hemorrhages intervention regardless systemic anticoagulation patients still reported complications vte primary outcome month follow revealed mrs patients dvst presents many diagnostic therapeutic challenges utility invasive interventions local thrombolysis mechanical thrombectomy fully understood exceedingly difficult conduct large randomized trials low incidence disease process large pathophysiological heterogeneity
multicomponent groundwater tracer tests conducted well characterized field site altona using inert carbon cored nanoparticles thermally degrading phenolic compound experiments conducted mesoscale reservoir consisting single subhorizontal bedding plane fracture located ground surface contained two wells separated reservoir rock initially degrees heated using degrees water heating process series tracer tests using thermally degrading tracers used characterize progressive situ heating fracture fiber optic distributed temperature sensing fodts used measure temperature rise orthogonal fracture surface locations recovery thermally degrading tracer product increased reservoir progressively heated indicating advancement thermal front proportional mass fraction thermally degrading tracer recovered gpr imaging fodts measurements reveal flow reduced narrow channel directly connected two wells led rapid thermal breakthrough computational modeling inert tracer heat transport two dimensional discrete fracture demonstrate subsurface characterization using inert tracers alone could uniquely characterize altona field site however inclusion thermally degrading tracer may permit accurate subsurface temperature monitoring altona field site however fluid rock interactions appear increased reaction rates relative laboratory based measurements made absence rock surfaces
sediment microbial fuel cells smfcs expected used renewable power source remote environmental monitoring therefore evaluation long term power performance critical usability paper present novel data needed understand long term performance smfcs used microemulsion dme doped anodes slowly release lactate fermented products tests anode limited smfcs without dme doped anodes operated months load simulating sensor operation found dclping anode electron donor reduced startup time increased maximum power compared control systems found long term steady power performance approximately maximum power similar finally small sized smfcs generated higher power densities literature versus using electron donor doped anodes practical short startup time initial high power needed however long term power critical addition electron donor provide practical advantage addition long term operation enrichment anode surface electrochemically active bacteria provide advantage elsevier ltd rights reserved
persons inject drugs opioid dependent comprise majority hcv infected united states national opioid epidemic unfolds increasing numbers people entering medical system access treatment opioid use disorder specifically buprenorphine yet little known hcv care patients accessing buprenorphine based opioid treatment sought determine hcv prevalence cascade care association patient characteristics completion hcv cascade care milestones patients initiating buprenorphine treatment reviewed electronic health records patients initiated buprenorphine treatment primary care clinic bronx january january patients initiated buprenorphine treatment confirmed chronic hcv infection patient characteristic associated achieving hcv care milestones retention opioid treatment patients retained retained buprenorphine treatment likely referred hcv specialty care achieve hcv specific evaluation offered hcv treatment initiate hcv treatment given current opioid epidemic growing number people receiving buprenorphine treatment unprecedented opportunity access treat persons hcv reducing hcv transmission morbidity mortality retention opioid treatment may improve linkage retention hcv care innovative models care integrate opioid drug treatment hcv treatment essential elsevier inc rights reserved
preschoolers attention deficit hyperactivity disorder disruptive behavior disorder often lack school readiness skills may risk subsequent poor academic achievement affects long term health well article describes challenges affected families children reviews diagnostic process primary care offers evidence based management options including behavior management training use stimulant medications
recent research suggests viewing face two social categories sex race activated simultaneously however multiple social categories including age race sex extracted faces present study present new method motivated previous research exploring costs benefits associated language switching examine whether performance attended social categorization task sex classification impacted changes switches two unattended social category dimensions race age predicted interaction effects transition switch versus repeat attended social categorization task transition two unattended social category dimensions specifically hypothesized across two trials attended categorization repeated male male people would quicker accurate unattended social categories also repeated younger face younger face relative switched younger face older face conversely across two trials attended categorization switched expected people would quicker accurate unattended social categories also switched relative repeated predictions supported across three experiments found unfamiliar face stimuli categorized according age expt race expt sex expt performance impacted switch repeat status unattended categories results suggest even cognitively occupied automatically simultaneously extract information faces pertain two unattended task irrelevant social categories elsevier inc rights reserved
second part results presentation investigations aerodynamics flow action space needle valves configurations characterised rounding sensitive sharp details present earlier investigations results pressure measurements action space walls two sections first one attention focused flows approaching outside entrance exit channel partly blocked various degrees insertion needle tip second section presents data pressure measured tip needle various lifts various reynolds numbers various configurations rounded sharp part valve components published elsevier
misinformation effect occurs eyewitness includes information account incongruent event witnessed stems exposed incorrect external sources yet little research undertaken techniques could protect eyewitnesses influence misinformation despite dangerous consequences distorted testimony article method enhancing self confidence called reinforced self affirmation rsa proven reduce misinformation effect five experiments first participants watched heard original event take place exposed post event material containing false information event finally given memory test original material rsa took place either post event material final test consisted self affirmation recalling greatest achievements life external positive feedback simulated good results memory test fake favourable results personality tests meta analysis five experiments revealed overall effect rsa reducing misinformation significant effect size suggesting technique potential developed practical use make eyewitnesses less vulnerable misinformation
utilization spectrum simulation many important fields widely made target spectral simulation technique important development trends rapid development application led technology led merits long serving life high lighting efficiency rapid responding time high wide selection light band consequently taking demands designing target spectral scene reproduction systems consideration led variable light bands light source performs gauss curve calculation fit spectra scene via matlab software therefore serving criteria selection led meanwhile system driving light source applies high performance embedded mcu main data processor chip led specific driver chip made corporation analyzing data collected target spectra scene processor transfers calculated results driver integrated circuit led spectrum scene reproduced basing results moreover design method also combine spectrometer directly realize real time capability reproduction spectra scene great potential application future
diagnosis testosterone deficit adult men made upon finding consistent symptoms signs associated confirmed low testosterone levels caused primary testicular failure decreased secretion secondary combination mixed type clinical features depend age onset completion pubertal development results eunuchoid traits easily detected clinical expression adult onset protean varied symptoms signs often overlapping aging several chronic conditions sexual problems low desire difficult erections frequently reported patients several symptom questionnaires proposed detecting however poor specificity weak correlation serum testosterone make unsuitable diagnostic tools although scores help monitoring future treatments physical examination usually yields significant data help detecting unidentified cases early onset measuring serum total testosterone levels mandatory available laboratories although commonly used methods fully satisfactory adult men lower limit normal reference range around nmol figure vary among laboratories grey zone values falling within interval around limit need clarification aim hospital laboratories calculate free bioavailable fractions biot shbg albumin levels diagnosis confirmed number additional tests measuring gonadotropins prolactin used find etiology summarized diagnostic algorithm need laboratory tests giving reliable estimate androgen sensitivity subject
paper concerned sampling interval dependent stability linear sampled data systems non uniform sampling new lyapunov like functional constructed derive sampling interval dependent stability results lyapunov like functional three features first depends time explicitly second may discontinuous sampling instants third required positive definite sampling instants moreover new lyapunov like functional make use information fully sampled data system including ends sampling interval making new proposition lyapunov like functional sampling interval dependent stability criterion reduced conservatism derived new sampling interval dependent stability criterion extended linear sampled data systems polytopic uncertainties finally examples given illustrate reduced conservatism stability criteria
language provides rich social information speakers instance adults children make inferences speaker social identity geographic origins group membership based language accent although infants prefer speakers familiar languages kinzler dupoux spelke little known developmental origins humans sensitivity language marker social identity investigated whether month olds use language person speaks indicator person likely social relationships infants familiarized videos two people spoke different languages viewed test videos two individuals affiliating disengaging results suggest infants expected two people spoke language likely affiliate two people spoke different languages thus infants view language meaningful social marker use language make inferences third party social relationships
yokukansan yks yokukansankachimpihange yksch traditional japanese kampo medicines latter comprises yks along medicinal herbs citrus unshiu peel pinellia tuber kampo medicines indicated treatment night crying irritability children neurosis insomnia adults recent clinical trials yks exhibited ameliorative effects behavioral psychological symptoms dementia aggressiveness excitement irritability present study aimed clarify involvement cholinergic degeneration nucleus basalis meynert nbm development aggressiveness rats subsequently using animal model effects yks yksch aggressiveness compared mechanisms underlying effects investigated glutamic acid glu injected right nbm rats induce deterioration cholinergic neurons day glu injection aggressive behaviors evaluated using resident intruder tests evaluation yks yksch administered rats aggressive behaviors daily days groups hta receptor antagonist way coadministered yks yksch period groups locomotor activity measured days glu injection day immunohistochemistry performed examine choline acetyltransferase chat activities nbm aggressive behaviors developed day glu injection maintained day yks yksch significantly ameliorated aggressive behaviors suppressive effects entirely abolished following coadministration way finally number chat positive cells right nbm significantly reduced day glu injection treatment yks yksch ameliorate reduced cell numbers results show unilateral glu injections nbm rats leads development aggressive behaviors thought reflect cholinergic degeneration yks yksch treatments ameliorated glu induced aggressive behaviors effects suggested mediated hta receptor stimulation improvement cholinergic degeneration
people parkinson disease reside homes family members nurses good position partner people family members better self management disease improved quality life purpose systematic review assess state science nursing research related year period total studies included review family caregiving studied topic followed symptom management medication adherence quality life end life palliative care functional status improving function recommendations future studies include developing testing interventions based theoretical models areas self management symptom management function improvement people caregivers caring people advanced stage building programs research interprofessional teams
study presents comprehensive analytical study fuzzy proportional integral derivative fuzzy pid controller derivative filter fuzzy pidf automatic generation control agc multi area power system tuned novel hybrid local unimodal sampling teaching learning based optimisation lus tlbo algorithm relevant advantage recommended controller high sensitivity load perturbation initially two area non reheat type thermal system considered gains pidf controller tuned employing hybrid lus tlbo algorithm supremacy pidf controller shown comparing results recently published articles study extended design fuzzy logic based pid controller derivative filter fuzzy pidf agc power system employing hybrid lus tlbo algorithm supremacy proposed approach shown comparing results another recently published article addition work also extended deal agc issues two area multi source hydro thermal power system using proposed controller finally seen fuzzy pidf controller retains supremacy pid pidf fuzzy pid controllers addition robustness analysis carried non reheat two area thermal power systems varying different parameters within range
basioccipital exoccipital lower part squamous occipital formed basal plate endochondral part occipital bone developed four ossification centers squamous occipital formed membrane cartilage early ossifi cation exoccipital basioccipital evident days consolidation different components occipital bone observed days complete ossifi cation squamous occipital basioccipital exoccipital noticed days
background ischemia reperfusion injury iri induced immune response critical issue transplantation complement contact system activation among key mechanisms study design investigated benefits pre reperfusion treatment recombinant human cinh rhcinh inhibitor complement contact activation pig model kidney autotransplantation subjecting organ min warm ischemia prior static preservation maximize damage results serum creatinine measurement showed treated animals recovered glomerular function quicker vehicle group however difference observed tubular function recovery elevated level urinary ngal neutrophil gelatinase associated lipocalin plasma ast aspartate aminotransferase detected indicating treatment influence iri mediated tubular cell necrosis regarding chronic graft outcome rhcinh significantly prevented fibrosis development improved function immunohistochemistry western blot showed decreased invasion macrophages lymphocytes reduction epithelial mesenchymal transition determined effect treatment complement activation immunofluorescence analyses min post reperfusion showing inhibition deposition mbl staining treated animals conclusions model inhibition complement activation rhcinh reperfusion completely counteracting iri limited immune system activation significantly improving graft outcome short long term
document image segmentation text lines one stages unconstrained handwritten document recognition paper presents new algorithm text line separation handwriting developed algorithm based method using projection profile employs thresholding threshold value variable permits determination low overlapping peaks graph proposed technique shown improve recognition rate relative traditional methods algorithm robust text line detection respect different text line lengths
background genetic environmental factors known related development childhood eczema aim assess environmental factors associated prevalence eczema among children using web based survey methods june conducted nation wide web based survey identify prevalence characteristics allergic diseases among japanese children prevalence allergic diseases including eczema assessed using international study asthma allergies childhood core questionnaire associations eczema prevalence environmental factors well background characteristics comorbid allergic diseases among year old children assessed results total children included analysis prevalence current eczema current eczema significantly associated higher prevalence wheeze rhinitis food allergy multiple logistic regression models birth autumn aor winter aor duration exclusive breastfeeding least months aor ownership pet infancy aor also associated higher prevalence eczema prevalence lower high annual household income aor siblings aor conclusions duration breastfeeding season birth pet ownership household income number siblings associated prevalence childhood eczema nationwide web survey copyright japanese society allergology production hosting elsevier
cancer care continues stress healthcare system increases life expectancy cancer prevalence survivors complex needs challenges compounded socioeconomic racial cultural disparities associated poor clinical outcomes one innovative resource wise strategy address demand system expanded use telehealth paradigm potential decrease healthcare patient pocket costs improve patient adherence recommended treatment surveillance
cheyne stokes respiration csr sleep studied extensively patients chronic heart failure chf prevalence prognostic significance csr wakefulness chf however largely unknown csr wakefulness apnea hypopnea cut moderate severe csr apnea hypopnea cutoff analyzed using polysomnographic recordings patients stable chf reduced left ventricular ejection fraction institution primary endpoint follow heart transplant free survival fifty patients csr wakefulness patients csr sleep csr wakefulness associated advanced age atrial fibrillation decreased ejection fraction increased end diastolic diameter brain natriuretic peptide new york heart failure class csr sleep months mean follow patients died patients underwent heart transplantation multivariate cox analysis identified age male gender chronic kidney disease ejection fraction predictors reduced transplant free survival csr wakefulness apnea hypopnea cutoff well moderate severe csr awake using apnea hypopnea cutoff predict reduced transplant free survival independently confounding factors csr wakefulness appears marker heart failure severity
global economy grows evolves century emerging technologies require mineral commodities greater scale larger number applications ever explosive growth economies nations concomitant explosive increase demand raw materials reasons potential supply restrictions portfolio minerals metals needed manufacturing dynamic supply raw materials used everyday products new emerging technologies curtailed many high tech sectors european industries could significantly affected example called tuning metals spice metals although used small essentially functional alloyings conventional metals indispensable power amplifier modern materials used vehicle construction materials principle recyclable however cases impossible recycle minor concentration application thus consumed faculty georesources materials engineering rwth aachen university initiating thereupon integrated interdisciplinary research three divisions faculty raw materials waste disposal technology metallurgy materials technology well geosciences geography collaborate issue sustaining critical raw materials availability supply materials needed futures industries guaranteed objective research cooperation develop life cycle strategies critical raw materials fundamental emerging technologies securing availability raw materials may accomplished improving efficiency raw materials chain enhancing raw materials base increasing also knowledge base field enable european society transfer resources economically efficient technically manageable well politically socially acceptable mineral metal reserves assuring sustainable availability critical metals paramount importance technical innovations researchers scientists faculty humanities rwth aachen university also involved study relation raw materials supply economic well social matters mapping sustainable strategies securing supply raw materials long run requires competence input scientists fields natural engineering political economical social sciences demand supply raw materials affected economy whereas global political social issues impact economy
paper presents method reconnection contour lines scanned color images topographical maps based graphics processing unit gpu implementation extraction contour lines shown brown color usgs maps difficult process due aliasing false colors induced scanning process due closely spaced intersecting overlapping features inherent map first effective method presented contour line reconnection scanned topographical maps based cpu method considers distance direction two broken points contour lines gets better performance high connection rate time complexity algorithm nonlinear increasing size topographical map second advantage massively parallel computing capability gpu compute unified device architecture taken improve algorithm finally better performance achieved based open source computer vision library experimental results show gpu implementation loop based patterns achieves speedup identical result compared implementation cpu
substantial number previous studies reported significant associations television viewing habits host detrimental outcomes including increased contact criminal justice system however remains unclear whether results flowing literature generalizable samples whether previously observed associations confounded due uncontrolled genetic influences current study addresses limitations using national longitudinal study adolescent adult health add health results preliminary models include controls genetic influences produced pattern results similar previously reported extant literature results genetically informed models revealed associations television viewing antisocial outcomes causal rather driven uncontrolled genetic influences replication required findings suggest results drawn extant literature may trustworthy
thermal management electric machine plays significant role improvement machine performance material selection different components one key stages electric machine design high efficiency high torque density applications stator slot liner copper winding laminate typically good electrical insulation poor thermal conductivity affects heat transfer winding stator significantly paper identifies key parameters slot liner selection effect parameters terms heat distribution stator motor using lumped parameters network simulation provides insight comparison various air gaps liner laminate conditions different liner impregnation materials impact manufacturing processes evaluated speed load operating conditions
carbon fiber composites organometallic intercalated polyaniline pani polypyrrole ppy doped polystyrene sulfonate pss electrochemically synthesized tested electrodes lithium ion batteries results obtained cyclic voltammetry ray photoelectron spectroscopy energy dispersive ray spectroscopy concluded incorporation copper ions polymeric composite successfully attained adsorption ions dimercapto thiadiazole dmct monomers carbon microfibers experimental electrochemical impedance response obtained pani dmct ion composite simulated adequate equivalent electrical circuits charge discharge cycles experimental discharge specific capacity pani dmct ion composite coulombic efficiency using mol liclo solution propylene carbonate polymeric electrolyte used charge discharge tests ppy pss pani composite anode high discharge specific capacity obtained cycles resulting ppy pss pani polymeric electrolyte pani dmct ion battery presented specific capacity could charged yielding energy density coulombic efficiency elsevier rights reserved
objective objective reproducible evaluation data quality paramount importance studies real world observational data summarise standardised data quality density generalisability process implemented msbase global multiple sclerosis cohort study methods error rate data density score generalisability score developed using patients enrolled msbase november data density score calculated across six domains follow demography visits relapses paraclinical data therapy emphasised data completeness error rate evaluated syntactic accuracy consistency data generalisability score evaluated believability demographic treatment information correlations among three scores number patients per centre evaluated results errors identified median rate per patient years generalisability score indicated samples representativeness known epidemiology moderate correlation density generalisability scores rho weak correlation error rate two scores rho observed generalisability score strongly correlated centre size rho conclusion implemented scores enable objective evaluation quality observational data impact design future analyses
paper uses particle swarm optimization pso algorithm adaptive weighted pso awpso algorithm genetic algorithm determine optimal proportional integral derivative controller parameters hydraulic position control system typical hydraulic servo system selected application mathematical model hydraulic servo system comprises relevant dynamics nonlinear effects considered model simulates behavior rexroth servo valve includes nonlinearities friction forces valve dynamics oil compressibility load influence performance indices used optimization process integral absolute error integral square error integral time absolute error proposed controller implemented simulation model identify best method tuning controller compared awpso results pso method found efficient robust improving step response position control hydraulic systems terms settling time maximum overshoot undershoot
high resolution reconstruction technology developed help enhance spatial resolution observational images ground based solar telescopes speckle masking near real time reconstruction performance achieved high performance cluster using message passing interface mpi however much time spent reconstructing solar subimages speckle reconstruction design implement novel parallel method speckle masking reconstruction solar subimage shared memory machine using openmp real tests performed verify correctness codes present details several parallel reconstruction steps parallel implementation various modules shows great speed increase compared single thread serial implementation speedup achieved one subimage reconstruction timing result reconstructing one subimage pixels shows clear advantage greater number threads novel parallel method valuable real time reconstruction solar images especially porting high performance cluster
introduction recent years sports community faced challenge determining safe return concussed athletes play given return play decisions partially dependent upon athletes endorsement symptoms better understanding factors contribute presence symptoms following concussion crucial purpose present study better characterize symptoms athletes endorse baseline determine impact various premorbid preinjury characteristics presence severity postconcussion symptoms acute injury period following concussion method two groups participants similar ages levels education examined athletes baseline postconcussion athletes administered comprehensive battery neuropsychological tests consisting neurocognitive neurobehavioral measures time periods main outcome measure post concussion symptoms scale pcss factor analysis conducted participants baseline pcss data determine factor structure pcss separate logistic regression analyses conducted examined baseline pcss symptom clusters derived factor analysis demographic variables baseline neurocognitive variables predictors dichotomized postconcussion pcss total scores low versus high symptom reporting following concussion results four distinct clusters emerged factor analysis measuring cognitive physical affective sleep symptoms logistic regression results indicated physical affective symptom clusters baseline reliably predicted athletes postconcussion symptom group sex neurocognitive composite score conclusions findings show certain baseline characteristics athletes confer risk greater symptomatology postconcussion knowledge risk factors assist management treatment sports related concussion
despite decades research obesity diabetes remain major health problems usa worldwide among many complications associated diabetes increased risk cardiovascular diseases including myocardial infarction heart failure recently micrornas emerged important players heart disease energy regulation however little work investigated role micrornas cardiac energy regulation human animal studies reported significant increase circulating free fatty acids triacylglycerol increased cardiac reliance fatty acid oxidation subsequent decrease glucose oxidation contributes insulin resistance lipotoxicity seen obesity diabetes importantly med initially identified negative regulator lipid accumulation drosophilia various metabolic genes downregulated med transgenic heart including sterol regulatory element binding protein moreover mir mir recently revealed key regulators lipid metabolism review focus role micrornas regulation cardiac total body energy metabolism also discuss pharmacological non pharmacological interventions target micrornas treatment obesity diabetes
serine acetyltransferase cyse belongs hexapeptide acetyltransferase family involved biosynthesis cysteine microorganisms mycobacterium tuberculosis cyse regarded potential target anti tuberculosis drugs however structure active sites tuberculosis cyse remain unknown present study aimed predict secondary structure construct model tuberculosis cyse using bioinformatics analysis determine essential amino acids associated cyse enzymatic activity amino acid sequences several microorganisms compared consensus sequence identified subsequently site directed mutagenesis used generate mutant tuberculosis cyse proteins enzyme assays demonstrated mutants abolished similar activity tuberculosis cyse prediction protein structure identification active amino acids tuberculosis cyse essential designing inhibitors may aid discovery effective anti drugs
purpose study study determined whether self reports unmet need help activities daily living adl disabilities prognostic emergency department utilization design methods prospective cohort study community living adl disabled subjects combined national long term care survey responses linked medicare data negative binomial count model computed assess association unmet adl need number subsequent admissions statistically adjusting predisposing enabling need characteristics associated admissions among older adults results adjusted annual incidence rate admissions higher unmet versus met need confidence interval admissions falls injuries higher unmet adl versus met adl need trended toward significance admissions skin breakdown significant admissions dehydration implications unmet adl need prognostic admissions especially falls injuries future research needed determine whether resolution unmet adl need reduces utilization
simply connected domain approximated good way embedded connected weighted graphs prove transfer current matrix defined edges graph viewed electrical network converges local weight factor differential green function observation implies properly rescaled correlations spanning tree model correlations minimal subconfigurations abelian sandpile model universal conformally covariant limit show periodic approximation domain pattern fields spanning tree model well minimal pattern zero height fields sandpile converge weakly distribution gaussian white noise
purpose study investigate whether individuals general population high scores autism spectrum quotient constituted single homogeneous group cohort university students investigated cluster analysis based original five subscales autism spectrum quotient based results analysis students could divided six clusters first low scores five subscales second high scores attention detail subscale third fourth intermediate scores subscales fifth high scores four five subscales low scores attention detail subscale sixth high scores five subscales students high total autism spectrum quotient scores divided two groups one high scores four subscales low scores attention detail subscale high scores five subscales results study suggested individuals general population high autism spectrum quotient scores may consist two qualitatively different groups
recently dynamic reliability block diagram drbd characteristics intuitiveness visibility extensively employed industrial fields aerospace military facilities nuclear energy chemical industry etc however exists limitation past research complexity reliability calculation considering additional modelling constructs state dependency sdep block spare part spare block load sharing lsh block address issue paper proposes dynamic bayesian networks dbn based converting drbd dbn based rules constructs drbd mapped dbn easily analyzed leveraging mature algorithms tools case study multiprocessor distributed computing system adopted illustrate conversion algorithm results show approach signally increase analytic efficiency drbd critical large scale system
paper shows performance curves obtained experimental campaign following different prime movers microturbine internal combustion engine sofc based hybrid system absorption chiller size related microturbine engine actual electrical power values hybrid system size electrical virtual power emulator rig used plant chiller value cooling thermal power experimental results obtained smart polygeneration facility installed innovative energy systems laboratory thermochemical power group university genoa facility designed perform tests smart grids equipped different generation technologies develop improve innovative control optimization tools performance curves obtained two different approaches tests real prime movers microturbine engine chiller measurements emulator rig hybrid system second case tests carried using experimental facility based coupling second microturbine modular vessel real time simulation software used components physically present experimental plant results significant improvement comparison available data experimental results presented different prime movers different operative conditions design part load operations moreover since manufacturers users usually able control air inlet temperature special attention devoted ambient temperature impact microturbine property strong influence performance machine reason empirical correlations ambient temperature effect obtained experiments objective perform easy implementation optimization tools experimental performance curves including several design conditions essential smart grid management implemented optimization tools allow find real optimal solutions tools based linear calculated correlations obtain results affected significant errors elsevier ltd rights reserved
usage glucocorticoid strong risk factor osteoporosis osteoporotic fracture opf chinese patients rheumatoid arthritis controlling daily dosage shortening course helpful preventing glucocorticoid induced osteoporosis giop opf chinese patients introduction study aims investigate prevalence risk factors giop also identify influences daily dosage treatment course giop chinese patients methods seven hundred ninety patients normal subjects enrolled study clinical laboratory features medications recorded detail bone mineral density bmd measured dual energy ray absorptiometry subjects results bmd measured sites significantly lower control group prevalence obviously higher group compared rawithout group prevalence ofopf group higher group without usage female age risk factors occurrence opf body mass index bmi protective factor prevalence giop opf statistical significance among groups different treatment courses whereas statistical difference found among groups different daily dosages conclusions giop exists generally chinese patients relates treatment course daily dosage usage also risk factor happening opf chinese patients
peripheral cell lymphoma otherwise specified ptcl nos corresponds heterogeneous group mature cell lymphomas recent gene expression profiling studies identified least two molecular subgroups gata tbx standard treatment outcomes remain poor high dose chemotherapy autologous stem cell transplantation incorporated primary therapy young fit patients remains ineffective tested randomized study several novel agents approved use relapsed refractory ptcls although response rates modest durable remissions reported selecting rationale combinations incorporating predictive biomarkers important moving forward improve outcomes patients ptcl
acceleration development internet things big data importance high performance mass data retrieval gradually highlighted cloud computing distributed data calculation model suitable big data widely used paper firstly technology cloud computing introduced secondly retrieval technology mass data analyzed finally high performance retrieval method mass data based hadoop proposed architecture method composed hdfs mapreduce hive divided four layers bottom top access layer interface layer management layer storage layer
average consensus widely used algorithm distributed computing control agents network constantly communicate update states order achieve agreement approach could result undesirable disclosure information initial state agent agents paper propose privacy preserving average consensus algorithm guarantee privacy initial state asymptotic consensus exact average initial values adding subtracting random noises consensus process characterize mean square convergence rate consensus algorithm derive covariance matrix maximum likelihood estimate initial state moreover prove proposed algorithm optimal sense disclose information necessary achieve average consensus numerical example provided illustrate effectiveness proposed design
combination effect pacritinib novel jak flt inhibitor erlotinib epidermal growth factor receptor tyrosine kinase inhibitor egfr tki non small cell lung cancer cells egfr activating mutations investigated combination showed synergistic effects jak mediated egfr tki resistant cells cases combination markedly suppressed pakt perk although pstat expression similar regardless treatment pacritinib pacritinib erlotinib control cells receptor tyrosine kinase array profiling demonstrated pacritinib suppressed met cells combined treatment pacritinib erlotinib xenografts showed tumor shrinkage compared drug monotherapy western blotting revealed pmet tumor samples inhibited results suggest met suppression pacritinib may play role overcoming egfr tki resistance mediated jak cells conclusion pacritinib combined egfr tki might potent strategy jak mediated egfr tki resistance elsevier inc rights reserved
smart mobile devices fostered new interaction scenarios demand sophisticated interfaces main developers operating systems devices provide apis developers implement applications including different solutions graphical interfaces sensor control voice interaction despite usefulness resources strategies defined coupling multimodal interface possibilities devices offer identify adapt user needs particularly important domains ambient assisted living paper propose framework allows developing context aware multimodal conversational agents dynamically incorporate user specific requirements preferences well characteristics interaction environment order improve personalize service provided proposal integrates facilities android api modular architecture emphasizes interaction management context awareness build user adapted robust maintainable applications proof concept used proposed framework develop android app older adults suffering alzheimer app helps preserve cognitive abilities enhance relationship environment
background lymphocyte expansion true lymphocytosis commonly observed everyday clinical practice meaning phenomenon often poorly understood discrimination benign malignant lymphocytosis remains difficult establish mainly true lymphocytosis rises patients affected immune mediated chronic inflammatory diseases immunosuppressive treatment conditions potentially associated lymphomagenesis brief report development mild pos lymphocytosis group patients chronic arthritis anti tnf alpha treatment described methods two hundred eight rheumatoid arthritis psoriatic arthritis psa patients evaluated longitudinally least year years anti tnf alpha therapy introduction possible appearance lymphocyte expansion patients developed lymphocyte expansion cells analysed results twenty five subjects developed mild cdpos lymphocytosis anti tnf alpha therapy reverted interruption higher lymphocyte count frequent use steroids shorter disease duration biological therapy start emerged risk factors lymphocytosis development conclusions first longitudinal cohort study evaluating onset lymphocytosis psa patients anti tnf alpha treatment possible clinical relevance mild cdpos lymphocytosis observed psa patients probably related anti tnf alpha treatment previously reported anecdotal cases patients higher baseline lymphocyte count use steroids shorter disease duration introduction biologic therapy seem prone develop laboratory reversible abnormality
whether encoding variability facilitates memory shown depend whether item specific relational processing performed across study blocks whether study items weakly strongly related variable processing groups studied word list using item specific task using relational task variable task groups two different study tasks recruited type processing block repeated task groups performed study task block recall recognition greatest variable processing group weakly related lists variable processing benefit also found task based processing list type processing complementary item specific processing related list rather redundant relational processing related list performing item specific relational processing across trials within trial yields encoding variability benefits may help reconcile decades contradictory findings area published elsevier inc
since eutrophication become serious water pollution problem urban lake china therefore accurate efficient methods necessary water quality assessment although bayesian methods widely used water quality modelling uncertainty analyses algorithm efficiency often limits application multi parameter eutrophication models study genetic algorithm integrated bayesian method improve sampling performance parameter calibration process eutrophication model urban lake north china tianjin established based biological processes external loads markov chain monte carlo method coupled genetic algorithm mcmc developed sample posterior parameter distributions calculate simulation results performances mcmc classical mcmc compared analyzed finally water quality assessment conducted eutrophication management results follows mcmc displays better convergence efficiency parameter sampling higher markov chain quality narrower upper lower confidence intervals classical mcmc method rainwater runoff nutrient loading must controlled urban lake restoration elsevier rights reserved
paper statement american geriatrics society ags core policy priorities society positions federal programs policies support older americans articulated new administration among ags priorities discussed paper health reform medicare medicaid ags committed leveraging expertise inform regulatory legislative policy proposals
paper presents application successive linearisation neural network implementation volterra filter applying signal flow graph approach new learning rules adaptation weights multilayer network structure obtained given multilayer structure presented applied signal processing including identification parameters plant noise cancelling signal prediction results simulation filter three basic application modes presented discussed
article presents analysis projected performance urban residential rainwater harvesting systems united states objectives quantify cities seven climatic regions water supply provided rainwater harvested residential parcel stormwater runoff reduction residential drainage catchment water saving efficiency determined using water balance approach applied daily time step range rainwater cistern sizes results show performance function cistern size climatic pattern single rain barrel gal installed residential parcel able provide approximately water saving efficiency nonpotable indoor water demand scenario cities east coast southeast midwest pacific northwest water saving efficiency cities mountain west southwest california stormwater management benefits quantified using environmental protection agency storm water management model results indicate rainwater harvesting reduce stormwater runoff volume semiarid regions less regions receiving greater rainfall amounts long term simulation overall results suggest cities individual residents benefit implementing rainwater harvesting stormwater control measure alternative source water
background patients frequent hospital readmissions high utilizer patients hups major driver rising healthcare costs united states group significant burden medical illness less known whether social determinants health may drive increased healthcare use poor health outcomes study aimed define population hups large safety net hospital system understand patients differ patients hups analyze demographic medical social factors contribute healthcare use mortality rates methods case control study data collected via retrospective chart review included patients admitted three times single calendar year controls one two admissions single calendar year matched age sex year high utilization used multivariable logistic regression models understand demographic clinical social factors associated hup status hup status independently associated mortality results factors contributed significant odds hup included medicaid medicare history recreational drug use homeless mortality rate among hups compared among controls conclusions data show social factors related high utilization population future efforts understand improve health population need incorporate non clinical patient factors
singapore national stroke association registered offers support information stroke survivors caregivers aims raise public stroke awareness last years developed programs equip stroke survivors caregivers knowledge life skills comfort opportunities socialization reintegration going public education advocacy initiatives obtaining funding member recruitment volunteer retention leadership renewal going challenges singapore national stroke association continue strive betterment stroke survivors caregivers public
social interaction feeling emotional closeness beloved ones mainly driven communication patients suffering serious disease due intense mood changes difficult keep regular contact relatives affects need direct verbal communication relatives continue participation others lives developed concept share daily activities current moods presence information using smart living room table first lab study prototype showed promising results regard expressiveness joy use usability
study objective identify factors might contribute pregnancies reported hysteroscopic sterilization worldwide design retrospective review commercial data compiled maude database medical literature manufacturer reports received commercial distribution hysteroscopic sterilization micro inserts canadian taskforce classification ill descriptive study measurements main results hysteroscopic sterilization kits distributed worldwide pregnancies reported estimated user population based number distributed kits data sufficient enable analysis pregnancies potential contributing factors showed associated patient physician noncompliance misinterpreted confirmation tests conceptions deemed occurred within weeks procedure therefore early detection identified cases conclusion although limitations dataset study design retrospective represents largest body cumulative hysterosdopic sterilization data available date pregnancies reported apparent might prevented greater patient clinician attention interim contraceptive use counseling rigorous evaluation informed interpretation procedure confirmation tests although estimated pregnancy rate based dataset likely underestimation suggest evaluable field performance hysteroscopic sterilization micro inserts consistent labeled age adjusted effectiveness years aagl rights reserved
today highly intertwined network society demand big data processing frameworks continuously growing widely adopted model process big data parallel distributed computing paper documents significant progress achieved field distributed computing frameworks particularly apache hama top level project apache software foundation based bulk synchronous parallel processing comparative studies empirical evaluations performed paper reveal hama potential efficacy big data applications particular present benchmark evaluation hama graph package apache giraph using pagerank algorithm results show performance hama better giraph terms scalability computational speed however despite great progress number challenging issues continue inhibit full potential hama used large scale paper also describes challenges analyzes solutions proposed overcome highlights research opportunities
crowdsourcing service pattern cloud environment usually aims cross disciplinary cooperation creating value together customers becomes increasingly prevalent software process kind software development management strategy defined series activities implemented software life cycle provides set rules various phases software engineering achieve desired objectives current software development cycle getting shorter facing frequent needs change fierce competition new resource management pattern proposed respond issues agilely introducing crowdsourcing service agile software development pushing agility software process user oriented resource scheduling method proposed rational use various resources process maximizing benefits parties experimental results proposed pattern resources scheduling method reduces greatly resource project resource manager increases team resource utilization rate greatly improves agility software process delivers software products quickly crowdsourcing pattern
leukemia blood disease creates inhibition differentiation increased proliferation rate nature known rich source medically useful substances high diversity bioactive molecules extracted marine invertebrates makes ideal candidates cancer research study done investigate cytotoxic effects dichloromethane brittle star extract doxorubicin cancer cells blood cancer cells cultured treated different concentrations brittle star ophiocoma erinaceus dichloromethane extract cell toxicity studied using mtt assay cell morphology examined using invert microscope apoptosis examined using annexin fitc propodium iodide dapi acridine orange propodium iodide staining eventually apoptosis pathways analyzed using measurement caspase activity statistical analysis performed using spss anova software tukey test considered significant mtt assay morphological observations showed dichloromethane extract inhibit cell growth dose dependent results considered extract also doxorubicin suppressed proliferation experiments related apoptosis analysis confirmed dichloromethane brittle star extract doxorubicin cytotoxic effect cells inic concentration study showed dichloromethane brittle star extract adjunct doxorubicin treatment leukemia cells
letter presents three phase voltage source inverter vsi topology reduce common mode voltage electromagnetic interference emi electric motor drives instead using filters active passive specific pulse width modulated pwm techniques reduce voltage proposed topology inherently less voltage generation addition two switches placed series lines topology effectively reduces voltage zero switching states floating inverter source topology implemented pwm method add additional complexity standard control techniques operation reduction capability topology first demonstrated simulation verified experimental results comparison common mode voltage emi made conventional three phase vsi demonstrate effectiveness proposed topology
decreased information processing speed ips frequently reported pediatric multiple sclerosis patients computerized version symbol digit modalities test sdmt measures ips eight consecutive trials per session additionally captures changes performance within session establish normative sdmt performance test retest reliability healthy children explore differences overall sdmt performance patients cross sectional study included female divided five age groups years patients female aged years average time complete sdmt increased age test retest reliability high icc total time complete sdmt differ children sex age matched however patients less likely show faster performance across successive eight trials compared healthy children demonstrate faster ips increasing age well successive trials sdmt inability pediatric patients maintain increase processing speed successive trials suggests reduced capacity procedural learning possibly resulting cognitive fatigue
paper proposes embedding resistive random access memory reram microcontroller unit data buffer communicating stand alone flash memory study chip manufactured using combination tsmc process industrial technology research institute reram back end line process reram equipped novel sense amplifier three magnification times reference cell current increasing read yield furthermore reram controller included built self test built self repair shortened bose chaudhuri hocquenghem error correlating code asymmetric coding yield reram approximately compared conventional dynamic random access memory dram buffer proposed architecture reduces system execution time power consumption mhz simulations also showed reram buffering runs least faster compared use nonvolatile memories ferroelectric ram phase change ram conduct bridge ram although reram buffering competitive speed power consumption spin transfer torque magnetorresistive ram buffering reram clear advantages area cost reliability
objective examine reliability functional weight bearing measure hindfoot alignment standing tibiocal caneal angle stca compare relative reliabilities goniometrically visually estimated stcas design prospective blinded comparison setting sports medicine center participants eighteen asymptomatic volunteer subjects men women age range interventions applicable main outcome measures two experienced examiners completed blinded goniometric stca blinded visual stca measurements subject right left ankles random order results quantitative visual goniometric stcas similar visual mean range degrees degrees valgus goniometric mean range degrees degrees valgus measurements exhibited good excellent intrarater reliabilities intraclass correlation coefficient icc range prediction limits degrees degrees interrater iccs fair measurement methods prediction limits degrees degrees terms relative reliability visual stca goniometric stca exhibited good excellent agreement icc range conclusions stca described herein exhibited acceptable intrarater reliability clinical use may acceptably reliable experienced examiners visual goniometric stca measurements quantitatively similar exhibited similar reliability using either method changes degrees time may attributable measurement error clinicians may consider using either stca measurement evaluating patients lower limb injuries screening high risk populations
investigating living brain remains one major obstacles psychiatry research order better understand biological underpinning brain disorders novel approaches needed study brain functions indirectly since part central nervous system retinal functions measured flash electroretinogram erg may reflect central dysfunctions reported psychiatric disorders review describes flash erg anomalies reported patients psychiatric disorders seasonal affective disorder schizophrenia autism spectrum disorder drug addiction discusses changes retinal functions might used biomarkers psychiatric disorder well potential aid diagnosis psychiatry elsevier inc rights reserved
high speed electric machines becoming increasingly important utilized many applications paper addresses considerations challenges rotor design high speed surface permanent magnet machines paper focuses particularly mechanical aspects design special attention given rotor sleeve design including thickness material permanent magnet design parameters discussed surface permanent magnet rotor dynamic considerations challenges also discussed
introduction avesicouterine fistula rare form urogenital fistula yet increasing prevalence united states rising rate cesarean deliveries vesicouterine fistulas various presentations including menouria hematuria urinary incontinence case presentation year old multiparous woman presented urine leakage third cesarean delivery treated mixed urinary incontinence overactive bladder medications midurethral sling continued complaints urine leakage patient noticed symptoms urine leakage improved menses used menstrual cup confirmation vesicouterine fistula patient underwent robotic assisted surgery symptoms insensible urine leakage resolved conclusions evaluating women urinary incontinence history cesarean deliveries use menstrual cup may aid diagnosis vesicouterine fistula robotic assisted laparoscopic repair tissue interposition flap efficacious minimally invasive method treatment vesicouterine fistula
purpose paper aims present system framework classifying different models military aircrafts based sound produce design methodology approach technique based extracting compact feature set two features extracted frequency domain aircrafts sound signals produced engines namely spectral centroid signal bandwidth features introduced artificial neural network classify aircraft signals findings current system identifies aircraft type among four military aircrafts mirage fighting falcon phantom starfighter experimental results show aforementioned types aircrafts accurately classified per cent via proposed method practical implications proposed system used low cost assistive tool already existing radar systems avoid cases missed detection false alarm importantly method used aircrafts use stealth technology detected using radar devices originality value proposed method constitutes novel approach classifying military aircrafts based sound signature utilizes two spectral features extracted sound aircraft engine features introduced neural network classifier
internet things natural continuity ambient intelligence smart ambient environments built mainly integrating large number interconnected smart objects sensors actuators smartphone appliances etc heterogeneous capabilities abstracted software services services composed fly provided time everywhere assist users daily activities key issue user centered services composition intelligently effectively discover select relevant services best match users requirements closely meet specified quality service level monitoring seamlessly provided services enhancing quality still challenging issue due mainly dynamicity uncertainty characterizing ambient environments paper propose new service oriented user centered event aware framework capable performing services monitoring handle automatically events may occur ambient environments monitoring based dynamic services discovery selection process enhance self adaptation unpredicted changes ensure services continuity best quality overall proposed framework implemented validated scenario dedicated daily activity recognition ambient assisted living environment addition obtained performances extensive tests show clearly efficiency feasibility proposed approach case large scale environment
background although philadelphia negative myeloproliferative neoplasms mpn usually aggressive type number molecular lesions impact greatly leukemic transformation indeed molecular background underlying progression still largely unexplored even though asxl idh srsf mutations together adverse karyotypic changes place patient high risk leukemic transformation case presentation patient year old man diagnosis jak primary myelofibrosis pmf unusually rapid leukemic transformation genomic profiling showed tet srsf mutations also present leukemic transformation patient developed complex chromosome rearrangement producing ewsr myb fusion remarkably expression myb target bcl respectively fold higher leukemic transformation chemotherapy patient obtained hematological remission time point ewsr myb fusion disappeared jak tet srsf mutations well pmf morphological features persisted conclusions rapid leukemic transformation jak pmf closely linked previously undescribed putative ewsr myb transcription factor detected disease evolution hypothesize ewsr myb contributed leukemia transformation least two mechanisms sustained myb expression consequently deregulated target bcl putative onco suppressor gene ectopic ewsr myb expression probably fulfilled oncogenic potential demonstrated myb fusions study confirmed myb recurrently involved chronic well leukemic transformation pmf appears valid molecular marker tailored treatments
background temporary permanent cognitive changes following transient ischemic attack minor stroke described previously unknown persisting cognitive deficits patients correlated acute infarction identified using magnetic resonance imaging aims tested hypothesis persistent cognitive impairment transient ischemic attack minor stroke predicted volume diffusion weighted imaging lesions methods acute transient ischemic attack minor stroke nih stroke scale score patients prospectively recruited within onset patients underwent montreal cognitive assessment magnetic resonance imaging including diffusion weighted imaging fluid attenuated inverse recovery sequences baseline days cognitive testing repeated day diffusion weighted imaging lesion fluid attenuated inverse recovery chronic white matter hyperintensity volumes measured planimetrically cognitive impairment defined priori montreal cognitive assessment score results one hundred fifteen patients imaged median inter quartile range onset acute ischemic lesions present patients cognitive impairment rates similar patients without diffusion weighted imaging lesions although linear regression indicated relationship acute diffusion weighted imaging lesion volume day montreal cognitive assessment scores white matter hyperintensity volumes baseline predictive persistent cognitive deficits days conclusions transient ischemic attack minor stroke patients suffer acute cognitive impairment post event deficits temporary deficits days onset correlated chronic white matter hyperintensity suggesting subclinical cognitive impairment impaired ability compensate effects acute ischemic infarcts
cad computer aided design environments surface commonly modeled collection connected regions represented parametric mappings meshing composite surface parallelized indirect approach dynamic load balancing used shared memory system however methodology inefficient practice existing cad systems use memory caches appropriate sequential process two solutions proposed referred pirate approach discrete approach first approach pirate library efficiently called parallel since caching used storage evaluation geometric primitives second approach cad environment replaced internal procedures interpolating discrete geometric support cases performance measurements presented show almost linear scaling elsevier ltd rights reserved
previously found vivo expanded human treg cells suppress proliferation lymphoma cell lines demonstrate immunomodulatory drug lenalidomide potentiates suppression lymphoma cell proliferation freshly isolated tregs well suppression tregs expanded polyclonally presence rapamycin cells cells regulation lymphoma cell proliferation tregs pre expanded third party allogeneic modcs presence rapamycin also potentiated lenalidomide lenalidomide contributed suppression exerted tregs despite concomitant downregulation treg proliferation lenalidomide reduce suppression conventional cells expanded tregs exposure polyclonally expanded tregs lenalidomide significantly alter phenotype uniform pattern lenalidomide effect treg mediated regulation lymphoma cells freshly isolated patients freshly isolated lymphoma cells activated multimeric cdl support survival vitro varied sensitivity lenalidomide regulatory effect tregs lymphoma cells ranged suppression help individual patients lenalidomide potentiated attenuated treg effects survival freshly isolated lymphoma cells combination lenalidomide treatment adoptive transfer tregs tregs expanded vivo could used suppress proliferation residual lymphoma select patients lymphoma responsive regulation tregs sensitive lenalidomide
purpose purpose study evaluate effect different reconstruction plates screw combinations stress distribution segmental resected mandibles using finite element analysis methods lateral lateral central defects simulated computer aided design modeling straight angular titanium locking reconstruction plates holes defects holes defects modeled screw diameter length total different screw placement combinations created bite force used present model unilateral molar clench data obtained finite element analysis recorded von mises maximum principle minimum principle stress values results observed stress values neck screw higher screws close resection area first screw loosened stress plate body remaining screws increased principle stress values within tolerance limits bone conclusion highest stress observed screws nearest resection edge therefore important place screw adjacent resection edge
background onychomycosis widespread public health problem rubrum mentagrophytes commenest causative organisms current medical therapy many drawbacks side effects methylene blue photodynamic therapy pdt proved efficacy lengthy sessions objectives optimizing methylene blue photodynamic therapy combination methylene blue photosensitizer gold nanoparticles aunps composite gold nanoparticles efficient delivery systems efficient enhancers photosensitizers antifungal photodynamic therapy materials methods eighty newzealand rabbit oryctolagus cuniculus used categorized eight equal groups follows healthy infection control composite photodynamic therapy five comparative groups photodynamic therapy initiated day three five post inoculation four sessions forty eight hours apart group divided light exposure two fluencies groups investigated macroscopically microscopically histopathology scanning electron microscope also flowcytometry assessment cell death ray analysis gold nanoparticles accumulation brain liver tissues determined results recovery infection approaching gold nanoparticles light group around methylene blue photodynamic therapy composite photodynamic therapy observed findings confirmed apparent decrease apoptosis however small amounts gold nanoparticles detected brain liver conclusion light stimulated gold nanoparticles promising tool treatment onychomycosis elsevier rights reserved
background readily available relatively easy use culturally adaptable developmental assessment tools young children southern africa overarching aim study test psychometric properties contextual appropriateness cut scores across age groups ages stages questionnaire third edition squires bricker among group typically developing children south africa zambia combination caregiver report direct observations compare children performance across sociodemographic variables methods sample consisted children zambia girls zambia girls south africa aged months months information caregiver employment education household assets also obtained results psychometric properties asq southern africa consistent found extant literature analysis item difficulty age reveals adequate levels difficulty majority items exception problem solving domain half items months poor pass rates sociodemographic variables significantly associated children performance higher caregiver levels education associated higher toddler scores personal social domain higher preschooler scores problem solving domain children whose caregivers earn salary higher fine motor scores toddlerhood higher problem solving scores preschool children attend preschools higher gross motor scores toddlerhood higher fine motor scores preschool years conclusions findings provide evidence support psychometric properties feasibility using asq south africa zambia combination caregiver report direct observations
symbolic execution technique enabling automatic generation test inputs exercise set execution paths within code unit tested paths cover sufficient part code test test data offer representative view actual behaviour code notably enables detecting errors correcting faults relational databases ubiquitous software symbolic execution code units manipulate remains non trivial problem particularly complex structure databases complex behaviour sql statements finding errors code units yet critical avoid corrupting important data work define symbolic execution translating database manipulation code directly constraints integrate traditional symbolic execution normal program code database tables represented relational symbols sql statements relational constraints symbols algorithm based principles presented symbolic execution simple java methods implement transactional use cases reading writing relational database latter subject data integrity constraints algorithm integrated test generation tool experimented sample code target language constraints produced tool smt lib standard used solver microsoft results show proposed approach enables generating meaningful test data including valid database content reasonable time particular solver shown scalable alloy solver used previous work solving relational constraints elsevier rights reserved
work presents necessary conditions implement numerically experimentally discrete versionobtained using euler discretization generalized chua circuit generator multi scroll chaotic attractors addition one degradation analysis chaotic dynamics calculation lyapunov exponents discretized version respect continuous model reported finally embedded system implemented validate obtained results using microcontroller pic three digital analog converters
fregoli delusion mistaken belief person currently present deluded person environment typically stranger familiar person disguise stranger believed psychologically identical known person present even though deluded person perceives physical appearance stranger different known person typical appearance gain deeper understanding contradictory error normal system tracking identifying known persons conducted detailed survey fregoli cases reported literature since seminal courbon fail paper preliminary reading cases revealed notable lack definitional clarity first formulated classification scheme different person misidentification delusions identify cases qualified instances fregoli according characterization mistaken belief known person present environment different guise typical appearance identified clear cases type set answer series questions motivated current hypotheses origin fregoli delusion asked whether patients misidentified particular strangers made reference misidentified known persons using wigs plastic surgery techniques disguise appearance misidentified many different strangers one showed symptoms particular misidentification delusions made inferences motives known persons disguise conclude discussing implications findings current hypotheses concerning origin fregoli delusion
achieve energy conservation prompt responses simultaneously paper propose novel energy saving data placement strategy called striping based energy aware sea applied raid structured storage systems noticeably save energy providing quick responses illustrate effectiveness sea implement two sea powered raid based data placement algorithms sea sea incorporating sea strategy raid raid respectively extensive experimental results demonstrate compared three well known data placement algorithms greedy sea sea reduce mean response time average least saving energy average less respectively
human resources backbone system key enabler functions effectively perform different immunization supply chain todays complex operating environment increasing strain caused new vaccines expanding immunization programmes source unicef order drive change required sustainability continuous improvement every immunization supply chain needs effective leader dedicated competent immunization supply chain leader adequate numbers skilled accountable motivated empowered personnel levels health system overcome existing emerging immunization supply chain isc challenges without effective supply chain leader supported capable motivated staff none interventions designed strengthen supply chain effective sustainable source gavi alliance strategy landscape analysis preceded evidence review march served inform global partner strategies country activities well highlight support required study also aimed define status quo order create form baseline measure impact interventions related going forward analysis comprised comprehensive desk review survey respondents countries consultations isc practitioners several forums findings highlight key areas inform pillars capacity development plan time revealed positive examples countries actively addressing issues identified putting place mechanisms structures optimize function published elsevier ltd
present article deals exact solutions dimensional system coupled konopelchenko dubrovsky equations similarity transformations method proposed seek solution system using lie group theory lie group theory strong tool complicated nonlinear partial differential equations group transformations remains invariant brief review lie symmetries system partial differential equations described process method reduces number independent variables one hence system partial equations reduces new system ordinary differential equations addition infinitesimals first reductions general previous established results kumar consequently solutions derived general previously known results obtained nine solutions explicit form general new best knowledge ultimately single solitons multi solitons shocks behaviour represented graphically numerical simulation physical validation results elsevier ltd rights reserved
group teachers materials engineering degree belongs organizing committee next national conference composite materials spain held rey juan carlos university madrid spain objective new ects experience involve twenty students fourth year organization development conference activity worth ects rey juan carlos university proposed activities related two subjects belong composite materials discipline composite materials third year manufacturing composite materials fourth year six activities following review proceedings submitted participants conference design poster based composite materials manufacturing techniques labs rey juan carlos university student stand explanation conference poster student proofreading layout conference proceedings participation students organization conference example first activity students review papers revised previously teachers made modifications insert errors students detect modifications related order magnitude units physical properties materials scale axis graphs conditions manufacturing processes etc review activity give students opportunity develop general competences critical reasoning ability apply knowledge practice etc specific ones related composite materials besides good experience students attend conference conferences related last advances composite materials relevant companies sector present two plenary sessions stands
band digital aeronautical communication system dacs promising candidate data link future air ground communication severely interfered pulse pairs pps generated distance measure equipment novel mitigation approach proposed paper firstly deformed detection dppd method combines filter bank correlation detection rescanning proposed detect deformed pps dpps caused multiple filters receiver secondly finite impulse response fir model used approximate overall characteristic filters waveform dpp acquired original waveform fir model finally sparse representation used estimate position amplitude dpp reconstruct dpp reconstructed dpps subtracted contaminated signal mitigate interference numerical experiments show bit error rate performance approach better recent works closer interference free environment chinese society aeronautics astronautics production hosting elsevier ltd
study aimed examine presence autism spectrum disorder asd sample female adolescents anorexia nervosa acute phase illness also compare level autistic traits social perception skills obsessive compulsive symptoms four groups asd two gender age matched control groups participants three scored conventional ados threshold asd participants similar controls autistic trait measures asd group obsessive compulsive measures theory mind ability affect recognition measures longitudinal studies needed order determine association conditions
residual carbon ammonium municipal wastewater treatment plant wwtp tail water lead fouling prejudice operation life time reverse osmosis membrane study new combined treatment system ozone oyster shells fix bed bioreactor ofbr membrane bioreactor mbr developed pilot scale tested days intensify removal residual carbon ammonium wwtp tail water results showed mean maximum cod ammonium removal efficiencies achieved optimum ozone dosage hrt single contribution ofbr mbr cod removal ammonium removal removal respectively high throughput sequencing data showed rich bacterial populations species deinococcus thermus firmicutes actinobacteria planctomyctes dominant reactors addition ozone deinococcus thermus planctomyctes species bacteria increased significantly ofbr firmicutes actinobacteria planctomyctes species bacteria increased remarkably mbr might mainly contribute carbon removal ofbr mbr respectively aerobic ammonia oxidizing bacteria nitrite oxidizing bacteria denitrifying bacteria existed reactors might main reasons high removal efficiency ammonium ofbr mbr system elsevier rights reserved
thiopurines mercaptopurine widely used chemotherapeutic agents treatment pediatric acute lymphoblastic leukemia dose limiting hematopoietic toxicity recently germline variants nudt identified major genetic cause related bone marrow suppression increasing interest clinical implementation nudt genotype guided dose individualization therefore sought evaluate effects nudt thiopurine metabolism identify pharmacologic markers inform nudt genotype guided dosing japanese children acute lymphoblastic leukemia simultaneously measured thioguanine nucleotides tgn red blood cells dna incorporated thioguanine dna white blood cells tgn levels significantly lower patients nudt deficiency likely toxicity related dose reduction contrast exposed dose dna accumulated efficiently vivo increasing number risk alleles nudt cytosolic tgn nuclear dna correlated positively across genotype groups ratio dna tgn significantly higher nudt deficient patients consistent excessive activation conclusion results suggest dna relevant metabolite tgn inform nudt genotype guided dose adjustments
days electrical motors generally utilized part everyday life matter small laptop hard disc till large electrical machines example fan refrigerator washing machine many electric motors sources drive direct equipment mechanical perspective paper mainly focuses application linear motion motors linear movement image sensor various electrical motors stepper motor advantage micro stepping ability manoeuvre per needed steps stepper motor miniaturized scale venturing finished pulse width modulation varying current considering accuracy every step error inside last step collected ensuing step stepper motor higher position preciseness sensible repetitive motion make increasingly attractive image sensor applications paper diverse electric motors examined compared see benefits motor identify one suitable utilized part movement sensor lens
paper first presents novel dual layer permanent magnet excited dpme synchronous motor extra set iron teeth employed inner stator rotor shaft provide additional variation magnetic reluctance along circumferential direction air gap strength flux modulation among magnetic fields produced armature windings pms improved proposed motor tactfully integrated two pairs flux modulated motors inside one frame one shared set armature windings advantage proposed dpme motor offers much higher torque capability conventional counterparts making competitive low speed high torque applications paper novel triple layer excited tpme synchronous motor presented similar operating principle dpme three layers inside frame finite element method magnetic field mechanical motion coupled computation employed evaluate electromagnetic torque precisely showcasing proposed dpme motor output extra torque compared conventional synchronous motor proposed tpme motor output additional torque similar power efficiency compared conventional synchronous motor
shape memory polymer smp kind smart material remember original shape actuating temperature comparing shape memory alloy smps large actuating deformation low density convenient fabrication shape stiffness smp responsible temperature heating actuating method recovery smp paper proposed kind electric heating method actuate smp embedded buckypaper sem heating shape recovery experimental test proved good bonding formed buckypaper smp uniformly distributing heating temperature quickly smp shape recovery
steady free surface flows produce sudden changes height velocity namely standing jumps demarcate supercritical subcritical flows standing jumps traditionally observed studied experimentally water order mimic various hydraulic configurations instance vicinity energy dissipators recently studies emerged investigate standing jumps formed flows dry granular materials relevant design protection dams avalanches present paper present new explicit relation prediction height standing jumps demonstrate robustness new relation proposed revisiting cross comparing great number data sets standing jumps formed water flows horizontal inclined smooth beds water flows horizontal rough beds flows dry granular materials smooth inclines study reveals limits traditional one one relation sequent depth ratio jump froude number incoming supercritical flow namely belanger equation latter rankine hugoniot relation take account gravitational frictional forces acting within jump volume jump length well possible density change across jump incoming fluid compressible newly proposed relation exact grains reasonable approximation water solve issues however relation predict height standing jump another length scale namely length jump known conclude study discussing empirical simple closure relations get reasonable estimate jump length water flows dry granular flows closure relations used feed general jump relation predict accuracy heights jumps number situations provided well calibrated friction laws described present study considered
goals assessed efficacy probiotic mixture bifidobacterium infantis breve longum improving abdominal pain quality life qol children irritable bowel syndrome ibs functional dyspepsia background associated functional gastrointestinal disorders particularly ibs common pediatrics well established treatment currently available although probiotics shown promising results adults data children heterogeneous study forty eight children ibs median age range age range randomized receive either mixture bifidobacteria placebo weeks week washout period patient switched group followed weeks baseline follow patients completed symptom diary qol questionnaire resolution represented primary outcome parameter results ibs bifidobacteria determined complete resolution significantly higher proportion children compared placebo significantly improved frequency proportion ibs children improvement qol significantly higher probiotics placebo finding confirmed conclusions children ibs mixture bifidobacterium infantis breve longum associated improvement qol findings confirmed subjects trial identifier nct http www clinicaltrial gov
study carried explore potential computer vision system cvs two hyper spectral imaging hsi systems covering visible short wave near infrared range long wave near infrared range respectively differentiation organic conventional farm raised salmon fillets fresh chill stored conditions partial least squares discriminant analysis pls support vector machine svm random forests classifiers used build classification models recognition authentication tested samples results suggested hyperspectral discrimination performed much better cvs validation set highest correct classification rate ccr equivalent presented two svm models one built full spectral variables four optimal wavelengths spectral region best prediction cvs obtained using pls ccr validation satisfying results hsi achieved applying svm algorithm full spectral region well important wavelengths ccrs validation nutshell hyperspectral imaging presented best predictive ability differentiate organic conventional salmon fillets svm classifier confirmed powerful multivariable analysis case overall outcome achieved research strongly suggested capability hyperspectral imaging objective rapid categorization two salmon varieties circumstances fresh chill stored conditions elsevier ltd rights reserved
netx family hilscher company highly integrated soc system architecture based arm cpu optimized communication industrial automation offers migration strategy field bus real time ethernet besides cpu couple communication channels peripherals integrated chip contribution describes study goal test usability netx according solving dsp tasks
swell shrink phenomena false water level steam generator produces difficult control water level steam generator presently three element controller cascade configuration two pid controllers widely used demonstrated method effective fast responsive however major problem dynamic condition parameters two pid controllers determined easily improved single neuron adaptive pid control strategy adopts proportional coefficient exponentially adaptively according error presented simulation results show feed water control system based improved single neuron adaptive pid controller faster response speed shorter regulate time smaller oscillation improves dynamic performance distinctly
virgin aggregate heated dried drum dryer uses heated mass heat dry reclaimed asphalt pavement rap recycled asphalt shingles ras materials drum mixer blending virgin asphalt binder however often virgin aggregate temperature inside dryer unknown since many dryers temperature measuring unit mixer end thermodynamics heat transfer principles applied predict virgin aggregate temperatures necessary dry heat rap ras varying moisture content various hot mix asphalt hma mix proportions among many results found hma mix consisting virgin aggregate moisture content rap moisture content temperature required raise virgin aggregate temperature degrees dry heat virgin aggregate rap verification purposes virgin aggregate temperature recorded drum plant facility thermodynamics heat transfer principles used predict virgin aggregate temperatures observed hma mix temperature predicted larger size virgin aggregate shows good agreement recorded value american society civil engineers
cost illness coi study undertaken estimate magnitude range lifetime effects associated child maltreatment australia using incidence based approach costs primarily estimated calculation population attributable fractions pafs determine marginal effects child maltreatment range outcomes pafs applied estimates expenditure inflated australian dollars projected life course according baseline age incident cases child maltreatment discounted per annum sensitivity analysis conducted using best lower bound estimate incidence child abuse best estimate total estimated lifetime financial costs incident cases child maltreatment billion cost per child maltreated lower bound billion best estimate lifetime costs associated reduced quality life premature mortality non financial costs incident cases child maltreatment billion per child maltreated considerable lifetime costs associated child maltreatment warrants expansion existing investment primary secondary prevention targeted support services children families risk elsevier ltd rights reserved
medical mistrust significant barrier medication adherence among african americans living hiv study african american people receiving antiretroviral therapy art southern city completed computerized measures community based research site multiple mediation modeling showed medical provider mistrust associated medication beliefs art adherence also medication beliefs predicted adherence indirect effects medical mistrust adherence via medication beliefs significant indirect effect significant medication concerns beliefs medication necessity beliefs medication concerns beliefs therefore mediate association medical mistrust art adherence
genome sequence assembly provides foundation studies genotypic phenotypic variation genome structure evolution target organism past four decades surge new sequencing technologies developments computational scientists developed new algorithms improve genome assembly discuss relationship sequencing technology improvements assembly algorithm development applied extend improve human nonhuman genome assemblies
introduction congenital heart disease chd common birth defect humans spite tremendous advance medical care chd still major contributor substantial morbidity mortality aggregating evidence demonstrates genetic defects play pivotal role pathogenesis chd increasing number genetic mutations identified responsible chd areas covered paper restricted molecular diagnosis chd highlights loss function mutations genes associated chd newly made progress molecular genetics chd reviewed article expert commentary heart development precisely coordinated biological process involving cellular proliferation differentiation migration integrated morphogenetic interactions interruption process predominantly genetic risk factors leads chd date mutations genes causally linked chd mutations cause loss function effect using next generation sequencing technology data processing software new chd associated genes easily discovered identification chd causative genes significant importance genetic diagnosis early prophylaxis personalized treatment chd patients
human left inferior parietal lobule lipl plays pivotal role many cognitive functions important node default mode network dmn although many previous studies proposed different parcellation schemes lipl detailed functional organization lipl exact correspondence dmn lipl subregions remain unclear mounting evidence indicates spontaneous fluctuations brain strongly associated cognitive performance behavioral level however whether consistent functional topographic organization lipl rest task revealed remains unknown used resting state functional connectivity rsfc task related coactivation patterns separately parcellate lipl identified seven subregions four subregions located supramarginal gyrus smg three subregions located angular gyrus subregion specific networks functional characterization revealed four anterior subregions found primarily involved sensorimotor processing movement imagination inhibitory control audition perception speech processing social cognition whereas three posterior subregions mainly involved episodic memory semantic processing spatial cognition results revealed detailed functional organization lipl suggested lipl functionally heterogeneous area addition present study demonstrated functional architecture lipl rest corresponds found task processing wiley periodicals inc
thermal hydraulic response large dry pressurized water reactor containments loss coolant accident conditions particularly respect containment pressure sump pool temperature crucial risk informed decision making generic safety issue texas university developed models several computer codes including melcor gothic model scenarios melcor best estimate thermal hydraulic severe accident code created actively maintained sandia national laboratories nuclear regulatory commission gothic thermal hydraulic software package meant design licensing safety calculations among systems nuclear power plant containments developed maintained numerical applications inc electronic power research institute overarching goal analyses presented twofold produce best estimate time profiles sump pool temperature double ended guillotine break conditions melcor gothic investigate differences melcor gothic code results via sensitivity study sump pool temperature selected key parameter compare direct implications sump pool chemistry residual heat removal recirculation pressure drop across sump screens aspects melcor gothic modeling strategies discussed best estimates containment thermal hydraulic response presented significant disagreements code predictions hypotheses explain differences tested comparative code sensitivity study context sensitivity refers containment thermal hydraulics respond differences code inputs code phenomenological models sensitivity calculations performed exclude individually model effects comparative thermal hydraulic responses containment fan coolers containment sprays thermal surface condensation films break source definition calculations also performed multiple models excluded using containment sump pool temperature indicator impactful physics terms code agreement thermal surfaces condensation film phenomena whereas fan cooler models minimal effect containment spray exclusion results disagreement parts event sequence break source definition break effluent flashing models lead disagreement
little known individual soil particles move soil surface result rainfall specifically virtually information pathway particle takes speed travels motion present novel technique give insight movement individual soil particles combining novel fluorescent videography techniques custom image processing fluorescent soil tracer able trace motion soil particles simulated rainfall laboratory soil flume system able track multiple sub millimeter particles simultaneously establishing position times second sub millimeter precision analysis toolkit developed enabling graphical numerical analysis data obtained example able visualise quantify parameters distance direction travel based observations created conceptual model stop hop roll attempts present unified model movement soil particles across soil surface hoped technology open new opportunities create parameterise evaluate soil models motion individual soil particles easily monitored authors published elsevier
integration python script language computer aided design simulation applications considered example physically correct optical simulation application approach based unified entity interface domain objects proposed particular scheme proposed extend application new types parametric objects writing extension classes simple structure special attention paid making api user friendly ensuring compliance object oriented programming principles
alternative hybrid time frequency domain approach compute periodic steady state electrical network presented network analysis include variety linear nonlinear components buses nonlinear reactors electronic devices proposed approach linear part network modeled frequency domain via equivalent input admittance nonlinear components buses resolved time domain equivalent interfaced nonlinear components via discrete fourier transform oft operations accounting harmonic interharmonic frequencies interfacing voltage current variables solved global gauss seidel procedure buses solved via local newton type iterative procedure shown proposed approach achieves faster computations traditional hybrid methods due compact equivalent representation linear part network gauss seidel iterative scheme avoids calculation inversions jacobians sample network used compare proposed method newton type solution scheme resulting waveforms also compared given pscad emtdc simulation software elsevier rights reserved
dynamic behavior propagation incoherent optical spatial solitons nonlocal nonlinear medium investigated means hirota method obtain soliton solutions based find vertical bar psi vertical bar positively related inversely related omega kappa whereas delta independent psi slowly varying amplitude beam delta refractive index change omega kappa unperturbed refractive index frequency propagating beam beam intensity distribution respectively head bound state soliton interactions given one interaction period decreases omega kappa increasing bound state one external perturbations taken consideration associated chaotic motions perturbed model studied corresponding power spectra phase projections obtained weak developed chaotic states investigated difference roots relative magnitude nonlinearities perturbations chaotic motions weakened via increasing omega kappa decreasing periodic motion obtained nonlinearities perturbations balanced
paper concerns effect stochastic resonance vibration isolation system rather reducing transmitted force shown possible significantly mask component force transmitted though isolator system excited harmonically achieved adding low intensity random noise harmonic excitation force nonlinear mechanical vibration isolation system used study consists vertical linear spring parallel two horizontal springs configured potential energy system double well prior analytical numerical study experiment demonstrate stochastic resonance mechanical system described elsevier ltd rights reserved
construction according green principles rather traditional methods poses new set risks project participants risks appropriately identified managed order prevent cost overruns study aims identify construction risks cost impacts leed certified projects purpose thirteen risks identified based literature survey categorized four groups issues consultant contractor subcontractor material product process iii legal regulatory contractual financial economic survey administered green building design construction practitioners assess likelihood occurrence risks respective impacts project cost according survey results risks associated consultant contractor subcontractor issues highest expected impact costs top five risk factors determined contractors subcontractors agreeing standards within expertise competence high cost certification lack expertise new products technologies doubts long term viability performance new untested products materials technologies inadequate definition project parties contractual roles responsibilities mitigating cost impact risks great value owners designers contractors recognizing risks associated leed certified projects cost impacts benefit practitioners
order mitigate excessive longitudinal displacement responses suspension bridge girders induced vehicle braking force one possible dynamic loadings combined control strategy consisting viscous dampers friction pendulum bearings developed paper firstly vehicle composition braking force models pingsheng bridge obtained traffic survey testing results respectively vibration response analysis bridge braking force implemented using midas finite element model furthermore viscous dampers friction pendulum bearings separately employed reduce vibration responses influence matrix method first used determine optimal parameters viscous dampers finally effect combined control strategy vibration control investigated numerical analysis results indicate utilizing influence matrix method parameter optimization viscous dampers feasible effective also shown longitudinal displacement response pingsheng bridge subjected vehicle braking force effectively mitigated viscous dampers friction pendulum bearings combined control optimized parameters combined control outperforms viscous dampers friction pendulum bearings alone
statistical analysis inter comparison solar radiation two sites cyprus representing two different climate regimes island athalassa inland plain larnaca coastal location covering period january december presented mean annual mean monthly daily totals global horizontal beam diffuse radiation frequency distribution sites computed discussed values skewness kurtosis coefficients used define frequency distribution type radiation parameters monthly basis statistical analysis extended daily clearness index diffuse ratio ratio horizontal beam global radiation furthermore influencing factors magnitude radiation components examined value used classify three different types days clear partially cloudy cloudy days statistical analysis solar radiation components performed average annual basis days classified either clear partially cloudy stations additionally influence atmospheric absorption scattering solar radiation clear skies examined basis linke turbidity factor results analysis used characterize compare radiation regimes two sites sites relatively high intensity global direct horizontal radiation annual average daily global radiation intensity athalassa larnaca horizontal beam radiation athalassa larnaca therefore fraction beam component global radiation comparatively high sites indicated annual average daily fraction greater generally larnaca slightly higher rates global radiation athalassa indicated average yearly cumulative global irradiation athalassa larnaca elsevier ltd rights reserved
background aims aimed assess levels education attained employment marital status adults diagnosed inflammatory bowel diseases ibd childhood adolescence compared healthy individuals canada methods performed cross sectional study adults diagnosed ibd childhood adolescence children hospital winnipeg manitoba january december participants answered semi structured questionnaire educational achievements employment marital status patients matched age sex random healthy individuals canadian community health survey controls per patient conditional binary logistic regression random effects ordinal logistic regression models used analysis results patients followed mean duration years range years persons ibd likely earn money per annum attain post secondary school degree receive diploma controls odds ratio confidence interval odds ratio confidence interval respectively significant difference patients controls employment marital status conclusions adults diagnosed ibd childhood seem achieve higher education levels individuals without ibd observation provide reassurance children ibd parents
paper consider nature electrodynamics absolute euclidean space time consequently also consider nature dynamics general many respects situation similar electro dynamics theory relativity respects pronounced differences lead instance new kinds modifications lorentz force law well coulomb law show easily null result trouton experiment understood means new kind electrodynamics addition investigate consequences reversal proper time turns theory leads prediction possible existence particles new electromagnetic characteristics finally make remarks concept internal space absolute euclidean space time
aim study examine association schizotypal borderline personality traits cannabis use participants college students males females mean age males mean age females completed self report questionnaires assessing cannabis use schizotypal borderline personality traits problematic cannabis use depressive symptoms borderline schizotypal traits significantly inter correlated logistic regression analysis showed borderline traits contributed significantly cannabis use total sample multiple regression analysis showed schizotypal traits positively uniquely associated problematic cannabis use symptoms among users results may imply schizotypal traits risk factor initiating use may facilitate development problematic use symptoms among users study showed necessity taking account schizotypal traits exploring relationships depressive symptoms borderline traits cannabis use elsevier ltd rights reserved
plants may change ecophysiological traits adapt new environments responses strongly depend species environmental conditions magnoliaceae species great scientific importance extremely endangered therefore crucial study ecophysiological adaptations situ conservation chose four common magnoliaceae species growing two botanical gardens located south north subtropical monsoon regions measured hydraulic photosynthetic traits wet dry seasons found plants growing north region showed significant lower leaf water potential predawn midday south region indicating species suffered severe drought stress north region result species north region lower stomatal conductance photosynthetic rates well smaller stomatal pore index addition significantly lower stem hydraulic conductivity two deciduous species north region observed compared species south region two evergreen species regions showed similar values stem hydraulic conductivity non significant differences leaf turgor loss points leaf conductance specific leaf area wood density found comparing species north south regions results suggested adjustment plant hydraulics local climatic conditions magnoliaceae species occurs primarily changes stomatal morphology function whereas contribution intraspecific variation leaf hydraulic traits appears limited
light detection ranging lidar data classification provides useful thematic maps numerous geospatial applications several methods algorithms proposed recently lidar data classification studies focused object based analysis advantages per pixel based methods however several issues parameter optimization attribute selection development transferable rulesets remain challenging topic study contributes lidar data classification developing approach integrates ant colony optimization aco rule based classification first lidar derived digital elevation digital surface models integrated high resolution orthophotos second processed raster segmented multiresolution segmentation method subsequently parameters optimized supervised technique based fuzzy analysis total attributes selected based general knowledge study area lidar data best subset containing attributes selected via aco attributes utilized develop rulesets use decision tree algorithm thematic map generated study area results revealed robustness proposed method overall accuracy similar kappa coefficient rule based approach attributes nearest neighbor knn classification method applied validate results proposed method overall accuracy rule based method attributes similar kappa whereas knn method overall accuracy produced poor thematic map selection aco algorithm justified comparison three well known feature selection methods hand transferability developed rules evaluated using second lidar dataset another study area overall accuracy kappa index second study area respectively overall findings indicate selection subset significant attributes important accurate lidar data classification object based methods
objectives determined performance sensor array electronic nose made metalloporphyrins coated quartz microbalances sensors diagnosis prognosis pulmonary tuberculosis using exhaled breath samples methods cases healthy controls prospectively enrolled signals volatile organic compounds vocs breath samples measured days therapy correlated clinical microbiological measurements results fifty one pulmonary cases healthy hiv uninfected controls enrolled study pulmonary cases coinfected hiv day treatment initiation sensitivity device estimated confidence interval specificity distinguishing cases controls time dependent changes breath signals identified time treatment progressed time dependent signal changes pronounced among hiv uninfected patients conclusion identification vocs signals breath samples using sensor array achieved high sensitivity specificity diagnosis allowed following signal changes treatment british infection association published elsevier ltd rights reserved
achieve enhanced biological response controlled degradation magnesium alloy modified biodegradable polymer coating called polycaprolactone pcl fabricated thermal approach heat treatment neither alters chemical composition pcl membrane rate magnesium ion release value weight loss compared untreated sample changes crystallinity hydrophilicity oxygen content heat treated pcl coating improve mechanical adhesion strength coating magnesium substrate also enhance biological properties moreover thermally modified sample lead higher spreading elongation osteoblasts due enhanced hydrophilicity functional group ratio analyses microcomputed tomography one four weeks postoperation total volume new bone formation heat treated sample higher untreated uncoated controls respectively surprisingly indentation modulus newly formed bone adjacent heat treated sample approximate higher controls promising results reveal clinical potential modified pcl coating magnesium alloy orthopedic applications
quantitatively image doping concentration capacitance high voltage lateral metal oxide semiconductor transistor device channel length ghz frequency using scanning microwave microscopy smm transistor embedded deep well forming flat junction substrate shape junction resolved smm images calibrated imaging device revealed doping concentration values range atoms including body drift region source diffusion well junctions silicon oxide interfaces minimum feature size smm electrical resolution smm doping concentrations compared technology computer aided design simulations resulting quantitative agreement model experiment images acquired different tip bias voltages allowing determine dopant polarity reflection scattering signal calibrated capacitance measurements obtained various transistor regions range results suggest dopant profiling capacitance measurements used quantitative nanoscale semiconductor device imaging
objective aim assess characteristics psa find well disease controlled real life demonstrate treatments identify unmet needs methods psa registry turkey multicentre web based registry established including rheumatology centres detailed data regarding demographics skin joint disease disease activity assessments treatment choices collected results one thousand eighty one patients women mean psa duration years enrolled frequent type psa polyarticular followed oligoarticular axial disease mean swollen tender joint counts respectively patients conventional synthetic dmard monotherapy anti tnf monotherapy using anti tnf plus conventional synthetic dmard combinations according das patients high moderate disease activity low disease activity achieved patients remission minimal disease activity data could calculated patients minimal disease activity major differences among sexes women older less frequent axial disease fatigue higher haq scores less remission conclusion psa registry turkey similarities previously published registries supporting external validity finding women fatigue worse functioning well high percentage active disease state highlight unmet need treatment psa
developed small lightweight single operator fuel cell vehicle fuel cell hydrogen gas tank university education purposes named pico fcy frame vehicle fabricated using thin rectangular aluminum rods motor reduction gear system used actuate system control system designed using pic microcomputer controls drive motor speed drive current purging non active gas fuel cell students able study design mechanical systems electrical circuits microcomputer programming development pico fcys also added benefit focusing student interest environmental consciousness working project paper discuss designs pico fcv provide running experimental results varied gear ratios
lamno attracted significant attention energy conversion storage materials especially promising noble metal free oxide catalyst new kind electrode material supercapacitors however poor electronic transport ability lamno hinders application thus improvement electronic transport ability essential enhance electron transfer catalyst active sites electrode effective avoid ohmic potential drop consequently energy loss work high quality epitaxial growth deficiency mno films obtained simple low cost polymer assisted deposition method found room temperature conductivity sigma doping mno increases nearly ten times compared parent lamno oxygen content driven enhancement conductivity discussed oriented mno film suggested existence laalo substrate beneficial stabilize deficiency mno compound site deficiency extends range oxygen content strain including epitaxial strain doping induced chemical strain annealing temperature cooperating oxygen content resulting oxygen stoichiometry independence ambient conditions high conductivity following process conductivity electronic state perovskite related material tuned practical application
remote data integrity checking rdic enables data storage server say cloud server prove verifier actually storing data owner data honestly date number rdic protocols proposed literature constructions suffer issue complex key management rely expensive public key infrastructure pki might hinder deployment rdic practice paper propose new construction identity based based rdic protocol making use key homomorphic cryptographic primitive reduce system complexity cost establishing managing public key authentication framework pki based rdic schemes formalize based rdic security model including security malicious cloud server zero knowledge privacy third party verifier proposed based rdic protocol leaks information stored data verifier rdic process new construction proven secure malicious server generic group model achieves zero knowledge privacy verifier extensive security analysis implementation results demonstrate proposed protocol provably secure practical real world applications
rainwater harvesting rwh decentralized practice provides water supply runoff reduction benefits often difficult assess assist evaluation model developed simulates single rwh system richmond virginia using storage volume roof area irrigated area indoor nonpotable demand storage dewatering goal independent design variables water supply runoff capture reliability assessed wide variety cases tradeoff curves developed evaluate design variable substitution reliability held constant reliability function fit simulation results solution method developed solve unknown variable function others method evaluates different design cases provide water supply runoff reliability demonstrating design variables substituted using care restrict substitutions functional inputs separately functional outputs method provide guidance designers selecting equivalent rwh systems regulators assessing runoff reduction goals results indicate dewatering goal enhances runoff capture reliability reduces water supply reliability moderately increases storage volume increased water supply runoff capture reliability irrigated area much larger negative effect water supply reliability roof area similar negative effect runoff capture reliability irrigated area increases population runoff capture reliability increases eventually remains constant reflecting dominance indoor demand turn reflects simulation assumption seasonal irrigation applications indicate land uses provide larger demands offices commercial sites high density residential sites may better suited lower density residential lots rwh commonly employed
paper presents application signal flow graphs sfg calculation higher order derivatives sensitivities linear circuit functions idea exact differentiation circuit functions based adjoint networks translated sfg language thanks application possible calculate exact value order derivative circuit function without knowing function explicit form moreover derivatives determined basis analysis two graphs circuits original adjoint one show sfg approach sensitivity calculation allows reduce greatly complexity calculations copyright john wiley sons ltd
rainwater harvesting rwh promising tool supplementing surface water groundwater supply overcome imbalance water supply demand changing climatic conditions main aim study present technically robust pragmatic methodology evaluating rainwater harvesting potential identifying suitable sites rwh artificial recharge structures using geographic information system gis based multi criteria decision analysis mcda unlike past studies study proposes approach prioritize zones sites rwh recharge structures great importance effective implementation rwh strategies derived themes runoff coefficient basic themes slope drainage density used mapping rainwater harvesting potential thereafter suitable zones sites feasible rwh recharge structures identified using suitability criteria gis based boolean logic addition identified zones sites prioritized based themes key factors viz post monsoon groundwater level groundwater fluctuation water demand normalizing weights themes features themes integrated gis environment study area divided four rwh potential zones study area falling high moderate rwh potential respectively hand study area classified four rainwater harvesting demand zones namely high study area high moderate low zones suitable constructing farm ponds cover percolation tanks ground cover sites percolation tanks along streams sites check dams also identified suitable locations study area framework prioritization suitable zones sites rwh groundwater recharge proposed study integrating rainwater harvesting potential rainwater harvesting demand maps integrated geospatial mcda approach time saving cost effective also helpful efficient planning management rainwater larger scale elsevier ltd rights reserved
factors influencing heterogeneous clinical manifestation hereditary angioedema due inh deficiency inh hae represent one oldest unsolved problems disease considering factor xii fxii levels may affect bradykinin production investigated contribution functional promoter polymorphism disease phenotype studied inh hae patients european families explored possible associations clinical features serping mutational status given cohort consisted related subjects implemented generalized estimating equations gees extension generalized linear model accounting within subject correlation carriers exhibited significantly delayed disease onset need long term treatment gee linear regression model presence significantly associated year delay disease onset regardless serping mutational status concluded carriage acts independent modifier inh hae severity
paper deals nanostructuring superconducting materials means swift heavy ion beams aim modify structural optical electromagnetic properties controlled way provide possibility making functional specific applications results presented concerning flux pinning effects implantation columnar defects nanosize cross section enhance critical currents irreversibility fields confined flux flow vortex guidance design devices locally tailoring superconducting material properties analysis disorder induced effects multi band superconductors studies carried different kinds superconducting samples single crystals thin films superconducting oxides magnesium diboride recently discovered iron based superconductors
cognitive tasks hard easy produce imprecise measurements ability turn attenuates group differences lead inaccurate conclusions clinical research aimed illustrate problem using popular experimental measure working memory back task suggest corrective strategies measuring working memory cognitive deficits schizophrenia samples undergraduates community controls outpatients schizophrenia inpatients schizophrenia completed back predictors task difficulty including load number word syllables presentation time experimentally manipulated using methodology combined techniques signal detection theory item response theory examined predictors difficulty precision back task load item type strongest predictors difficulty measurement precision associated ability ability varied group result patients measured precisely controls although difficulty well matched ability levels impaired examinees task conditions easy nonimpaired participants simulation study back tasks primarily consisting back load conditions unreliable attenuated effect size cohen much results suggest back tasks commonly designed may underestimate patients cognitive deficits result nonoptimized measurement properties overall cautionary study provides template identifying correcting measurement problems clinical studies abnormal cognition
paper facilitates conception signal flow graph theory makes possible determine angular velocity planetary gear trains design planetary gear train determination angular velocity one important subjucts almost method used kinematic analysis planetary gear train inherent gearing tedious oroder make easy analysis planetary gear train article proposes representation algebraic vector equation graph theory problems moreover article presents examples application method complex type type type paradox gear trains
optogenetic systems utilize genetically encoded proteins change conformation response specific wavelengths light alter cellular processes need culturing measuring systems incorporate programmed illumination stimulation optogenetic systems present protocol building using continuous culturing apparatus illuminate microbial cells programmed doses light automatically acquire analyze images cells effluent operation apparatus chemostat allows growth rate cellular environment tightly controlled effluent continuous cell culture regularly sampled cells imaged multi channel microscopy culturing sampling imaging image analysis fully automated dynamic responses fluorescence intensity cellular morphology cells sampled culture effluent measured multiple days without user input demonstrate utility culturing apparatus dynamically inducing protein production strain saccharomyces cerevisiae engineered optogenetic system activates transcription
paper proposes simple approach measure elbow joint angle eja using galvanic coupling system gcs directly whereas traditional methods involved either complex machine learning task arm movement models consideration model parameters accurate often first correlation eja gcs data established defining polynomial function based simple six impedance model human upper arm eja theta achieved moving forearm along sagittal transverse planes different loads empty hand coefficients polynomial estimated based polynomial fit technique actual angles reference frame calculated using motion data total eleven subjects seven males four females age years considered experiment however gcs data eight subjects used derive correlation exclusively furthermore influence muscle fatigue different loads derived correlation studied next based derived correlation eja measured two parts inside outside tests considering six subjects results show proposed idea measure eja effectively error rad degrees moreover performance comparison proposed approach shows compatibility indicating low complexity higher accuracy easy measure
objectives determine whether treating conditions medically unexplained symptoms associated lower physician satisfaction higher ascribed patient responsibility determine whether higher ascribed patient responsibility associated lower physician satisfaction treating given condition methods surveyed nationally representative sample primary care physicians respondents asked responsible patients two conditions developed medical explanations depression anxiety two conditions less developed medical explanations chronic back pain fibromyalgia much satisfaction experienced treating condition used wald tests compare mean satisfaction ascribed patient responsibility medically explained conditions medically unexplained conditions conducted single level multilevel ordinal logistic models test relation ascribed patient responsibility physician satisfaction results treating medically unexplained conditions elicited less satisfaction treating medically explained conditions wald physicians attribute significantly patient responsibility former wald although magnitude difference small across four conditions physicians reported experiencing less satisfaction treating symptoms result choices patients responsible multilevel odds ratio conclusions physicians experience less satisfaction treating conditions characterized medically unexplained conditions treating conditions believe patient responsible
generic rainwater harvesting system including catchment area command area often equipped rainwater storage tanks stochastic nature precipitation dominates water balance rainwater harvesting systems theory stochastic control better serves determining optimal strategies water management mathematical model consisting stochastic differential equations model parameters identified observed data developed describe dynamics rainwater harvesting systems irrigation stochastic control problems formulated solved obtain optimal irrigation strategies dry spells procedure inversely applicable designing dimensions system identification model parameters demonstrated data observed experimental micro rainwater harvesting system japan well semiarid savanna ghana real life application discussed context jordan rift valley rainwater harvesting system developed elsevier ltd rights reserved
gluten induced aggregation cells represents vitro model reproducing early steps occurring small bowel celiac patients exposed gliadin despite clear involvement activation antigen presenting cells yet clear compartment occurs herein study calcium dependent aggregation cells using either cell permeable cell impermeable inhibitors gluten induces efficient aggregation calcium absent extracellular environment inhibitors restore full aggregating potential gluten presence calcium findings suggest activity essential cellular aggregation mechanism demonstrate gluten contacts cells provokes aggregation mechanism involving gliadin peptide peptide also activates cell surface associated extracellular absence calcium using bioinformatics approach identify possible docking sites peptide open closed structures peptide docks closed structure near gtp gdp site establishing molecular interactions amino acids involved stabilization gtp binding suggest may occur displacement gtp switching structure closed active open conformation furthermore docking analysis shows peptide binding beta sandwich domain closed structure suggesting region could responsible different aggregating effects gluten shown presence absence calcium deduce data possible mechanism action gluten makes contact cell surface could possible implications celiac disease onset
vast majority research child abuse potential concentrated women demonstrating varying levels risk perpetrating physical child abuse contrast current study considered factors predictive physical child abuse potential group male intimate partner violence offenders group would represent likely high risk group elements social information processing theory evaluated including pre existing schemas empathy anger attitudes approving parent child aggression considered potential moderators negative attributions child behavior lend methodological rigor study also utilized multiple measures multiple methods including analog tasks predict child abuse risk contrary expectations findings support role anger independently predicting child abuse risk sample men however preexisting beliefs approving parent child aggression lower empathy negative child behavior attributions independently predicted abuse potential addition greater anger poorer empathy favorable attitudes toward parent child aggression also exacerbated men negative child attributions elevate child abuse risk future work encouraged consider factors commonly considered women parallel diverge observed elevate child abuse risk men varying levels risk elsevier ltd rights reserved
background women choose range contraceptive methods differ important ways inadequate decision support may lead select method poorly fits circumstances leading dissatisfaction misuse nonuse decision support interventions decision aids may help women choose method contraception best fits personal circumstances guide future decision aid development aim summarize attributes contraceptive methods included available decision aids well surveys interviews women actively choosing contraceptive method methods conducted systematic review identify attributes contraceptive methods may important women engaging decision making process performed database search medline pubmed ovid embase ovid central ovid psycinfo ebsco cinahl popline scopus identify decision aids structured interviews questionnaires reporting attributes contraceptive options importance women free text internet search also performed identify additional decision support tools articles tools reviewed duplicate inclusion summary list attributes compiled results included surveys semistructured interview report decision aids reporting unique attributes attributes consistently included surveys interviews decision aids several included often decision aids opposed surveys interviews sti prevention noncontraceptive benefits method used requirement healthcare provider vice versa woman vicarious experience contraceptive methods key attributes mentioned surveys interviews decision aids include efficacy total mentioned side effects health risks total mentioned limited number decision support tools formally evaluated many rigorously studied conclusions many attributes identified potentially important women choosing method contraception inconsistently included reviewed resources formal evaluation decision support tools contraceptive choice involvement users development process may lead user centered design implementation
transfer function electrical power lines broadband power line communication bplc investigated signal flow graph analysis work intends present new simple didactic way model transfer function multi path model attenuation losses taken account results compared transfer function obtained abcd model measurements coax cables electrical grids presented results investigated
liquid petri dish spontaneously circulates radial pattern even dish rest fluid flows observed utilized biological research origins well studied particle tracking measure velocities radial fluid flows shown linked evaporation used infrared thermal imagnn used identify thermal gradients air liquid interface bottom dish two color ratiometric confocal imaging used measure thermal gradients vertical direction within fluid finite element model fluid incorporating measured temperature profiles shows buoyancy forces sufficient produce flows consistent measured particle velocity results flows may arise dish plate formats may impact biological research positive negative ways american institute chemical engineers
purpose review provide overview molecular basis familial hypercholesterolemia recent findings familial hypercholesterolemia common hereditary cause premature coronary heart disease estimated every individuals heterozygous familial hypercholesterolemia fewer patients familial hypercholesterolemia identified across globe heterozygous familial hypercholesterolemia left untreated likely coronary heart disease manifest clinically prior age years half patients prematurely die consequences myocardial infarction crucial understand molecular basis familial hypercholesterolemia diagnose familial hypercholesterolemia properly summary phenotype familial hypercholesterolemia caused mutations ldlr apob pcsk genes explains approximately familial hypercholesterolemia cases means next generation sequencing increasing number mutations established putative novel genes associated phenotype identified
background due popularity public service announcements psas well broader health social harms associated illicit drug use study sought investigate drug prevention messages found government canada drugsnotme campaign understood experienced engaged among group street involved young people vancouver canada methods qualitative interviews conducted individuals enrolled risk youth study thematic analysis conducted results findings indicate campaign messages neither resonated risk youth provided information resources support cases messaging exacerbated social suffering experienced individuals conclusions study underscores importance rigorous evaluation psas need consider diverting funds allocated drug prevention campaigns social services meaningfully address structural drivers drug related harms among vulnerable youth populations
study examine conditions moderate auditor resistance toward susceptibility believing client provided lies particular predict auditors directly refute incorrect management explanations evidence related memories susceptible misinformation effect effect describes phenomenon individual recalls false memories based client lies instead real memories use laboratory experiment involving professional auditors must compile industry related evidence corroborate invalid management explanation expected find auditors better developed evidence memories provide lower evaluations management credibility explanation sufficiency presented blatantly incorrect explanation subsequently prompted access related information auditors poorly developed evidence memories give responses consistent management provided false memories instead previously gathered evidence memories auditors identifying incorrect explanation succumb misinformation effect exhibited recall consistent evidence memories overall results show client discussion produce delayed effect inducing form memory error auditors subsequently retrieve evidence stored memory
alzheimer disease common dementia trigger pathological cascade widely believed overproduction accumulation beta amyloid protein beta affected brain however effective remedies still anxiously awaited recent evidence suggests curcumin may potential agent treatment study used xfad transgenic mice model investigate effects curcumin results showed curcumin administration day intragastrically days dramatically reduced beta production downregulating bace expression preventing synaptic degradation improving spatial learning memory impairment xfad mice findings suggest curcumin potential candidate treatment
present technique representing bounded degree planar graphs succinct fashion permitting efficient traversal paths using representation graph vertices paper denotes associated key bits stored bits traversing path length takes denotes disk block size applying construction dual terrain represented triangular irregular network represent terrain space bounds support path traversals terrain using number triangles visited path useful answering number queries terrain reporting terrain profiles trickle paths connected components
study investigates change multiple glacier parameters three valley type glaciers sakchum chhota shigri bara shigri located chandra basin himachal himalaya sharing climatic regime assesses control nonclimatic factors wholesome glacier response multitemporal satellite remote sensing data landsat etm oli terra aster along srtm digital elevation model used extraction glacier parameters results show retreated lost area remained relatively stable retreat rate area loss however results surface ice velocities siv change surface elevation change suggest comparable slowing surface lowering debris cover also varied substantially glaciers results reveal higher retreat deglaciation glaciers associated higher altitudinal range slow siv lower ablation zones laz glacier hypsometry debris cover glaciers found controlled slope higher deglaciation rates higher upper ablation zone uaz coupled lower siv laz surface lowering glacier primarily governed slope gradient differential surface lowering size accumulation zone acz results confirm presence stagnant zones lower ablations upstream upstream major siv dropdown uaz indicating expansion stagnant zones farther glacier surface lowering seemed influenced ice flux changing spatial distribution debris cover presence supraglacial lakes ice cliffs bordering melting around supraglacial lakes backwasting ice cliffs may prime reasons behind intense mass loss observed stagnant zone bara shigri glacier surface lowering similar higher glacier wide thinning differential surface lowering glaciers reduced surface gradient hence also rapid surface gradient changes dropdown sakchum glacier indicate possible development supraglacial lakes future interestingly despite close proximity demonstrate three distinct ablation patterns reemphasizing role nonclimatic factors overall study states mutual variation glacier parameters together nonclimatic factors exercise great control glacier response elsevier rights reserved
work problem intracellular currents longilinear bacteria escherichia coli suspended physiological medium submitted harmonic voltage analyzed using finite element based software comsol multiphysics bacterium modeled cylindrical capsule ended semi spheres surrounded dielectric cell wall equivalent single layer cell wall defined starting well recognized three shell modeling approach bacterium considered immersed physiological medium also taken account modeling new complex transconductance thus introduced relating complex ratio current inside bacterium voltage applied two parallel equipotential planes separated realistic distance voltage applied longitudinally relative bacterium main axis numerical results terms frequency response mhz range coli cells revealed transconductance magnitude exhibited maximum frequency depending cell wall capacitance occurred spite purely passive character model could explained equivalent electrical network giving similar results showing special conditions lateral paths currents cell wall shown main contribution behavior due conductive part current wiley periodicals inc
many control engineering applications impossible expensive measure states dynamical system system output available controller design study new dynamic output feedback control algorithm proposed stabilize unstable periodic orbit chaotic spinning disks incomplete state information proposed control structure based fuzzy systems investigation also introduces new design procedure satisfy constraint fuzzy dynamic output feedback control signal procedure independent exact value initial states finally computer simulations accomplished illustrate performance proposed control algorithm wiley periodicals inc
acacia nilotica seed shell ash supported feo magnetic nanoparticles synthesized low cost simple environmentally benign procedure adsorbent characterized several methods including ray diffraction scanning electron microscopy fourier transform infrared spectroscopy potential acacia nilotica seed shell ash supported feo magnetic nanoparticles investigated adsorption effect different parameters including contact time adsorbent dosage initial concentration removal yield studied experimental data fitted well pseudo second order kinetic model adsorption isotherm described well langmuir isotherm maximum monolayer adsorption capacity process purifying water treatment presented easy using magnetic nanoparticles therefore adsorbent found useful valuable controlling water pollution due ions
rapid development economy electrical load increasing year year resulting low voltage phenomenon peak time user side affecting lives residents seriously based understanding causes low voltage paper makes analysis impact area voltage regularity combinations using control measures distribution transformer load voltage regulation low voltage reactive power compensation bus voltage regulation establishes characterization multiple correlation area low voltage distribution network adjust change process dynamic hybrid model derives sensitivity function area voltage regulation variables order determine different low voltage corresponding adjustment measures improve combination priorities taking constraints distribution network area voltage level account makes multi purpose function priority ranking function includes voltage deviation network loss minimum adjustment costs etc integrates means voltage regulation makes design predictive control based multipurpose constraint model area voltage control strategy considering constraints safe operation target priority
antibacterial resistance leadership group arlg laboratory center leads evaluation development implementation laboratory based research providing scientific leadership supporting standard specialized laboratory services developed physical biorepository virtual biorepository physical biorepository contains bacterial isolates arlg funded studies located centralized laboratory available arlg investigators web based virtual biorepository strain catalogue includes well characterized gram positive gram negative bacterial strains published arlg investigators collaboration arlg leadership operations center developed procedures review approval strain requests guidance selection process shipping strains distributing laboratories requesting investigators arlg strains scientific technical guidance provided basic research laboratories diagnostic companies research development facilitating collaboration diagnostic companies arlg master protocol evaluating multiple infection diagnostics mastermind initiative evaluation multiple diagnostic devices single patient sampling event addition completed several laboratory based studies designed help evaluate new rapid molecular diagnostics developing testing applying mastermind approach using purified bacterial strains collaboration arlg statistical data management center sdmc developed novel analytical strategies integrate microbiologic genetic data improved accurate identification antimicrobial resistance novel approaches aid design future arlg studies help correlate pathogenic markers clinical outcomes accomplishments result successful collaboration arlg leadership operations center diagnostics devices committee sdmc interactive approach pivotal success projects
prior work shows children selectively learn credible speakers yet little known treat information non credible speakers research examined extent conditions children may may learn problematic sources three studies found children displayed trust toward previously inaccurate speakers children equally likely extend labels previously accurate inaccurate speakers novel objects moreover expected third parties share labels provided previously inaccurate speakers clear evidence speakers information wrong case speakers perceptual access information blocked young children reject label together findings provide evidence young children completely ignore labels supplied non credible speakers unless strong reason
access control critical many applications internet things iot since owner iot device application may permit one user access subset resources device provide access control iot network recent work adopted capability based access control cbac model allows iot device decide authorization based capability token however existing approaches based cbac directly attach capability token end coap sending request message receiver easy retrieve capability token request message coap payload present coap length field indicate size payload counter problem propose coap option cap token encapsulate capability token sending request messages coap option independent coap fields receiver get capability token cap token option request message without ambiguity also provide compression mechanism reduce size cap token option evaluation shows compression mechanism save size option adding compressed cap token option request message increases datagram size bytes increase directly attaching capability token end coap
objective small levothyroxine dose changes lead significant clinical effects ensure thyroid hormone levels safely maintained authorities increasingly adopting stricter potency specifications stringent labeled dose whole shelf life levothyroxine sodium euthyrox eutirox levothyrox reformulated two studies performed ensure bioequivalence currently marketed formulation dosage form proportionality new formulation methods bioequivalence study open label randomized single dose two period twosequence crossover comparing highest dosage strengths currently marketed new formulation total dose dosage form proportionality study open label randomized three period six sequence crossover comparing tablets total dose blood samples taken predefined time intervals primary outcomes area curve auc maximum concentration max thyroxine plasma results bioequivalence study comparing profiles new current formulation geometric least square mean ratio baseline adjusted auc adj confidence interval max adj bioequivalence established lay within predefined limits dosage form proportionality study pairwise comparisons ranged cis within predefined range three dose strengths dosage form proportional conclusions new formulation meets stringent potency specification guidelines demonstrated bioequivalent current formulation show dosage form proportionality new formulation enable patients receive dose fine tuned medical needs contributing improved safety use
backgroundit known asthma related obesity also small birthweight objective study clarify issue assessing putative relationship changes corpulence birth childhood assessed body mass index bmi asthma phenotypes methodsthe following status corpulence assessed schoolchildren using quartile bmi birth around years underweight birth around underweight birth overweight around overweight birth underweight around overweight birth around reference group constituted children corpulence changes extreme determination asthma phenotypes allergic non allergic exercise induced asthma based clinical examination including skin prick tests exercise challenge test questionnaire resultsthe risk allergic asthma higher children persistent underweight children persistent overweight children becoming markedly corpulent boys risk allergic asthma significantly higher less corpulent children birth regardless whether remained become overweight girls risk allergic asthma significantly higher persistent overweight significant associations bmi changes non allergic exercise induced asthma conclusionswe observed extreme changes bmi persistent underweight persistent overweight childhood increased risk allergic asthma
background aims year prospective study aimed identify baseline parameters predicted progression carotid femoral pulse wave velocity pwv used evaluate aortic stiffness among singapore multi ethnic asians type diabetes tdm methods pwv measured gold standard tonometry method tdm subjects baseline follow annual rate pwv change calculated individuals percentile rate per year regarded rapid progressors subgroup analysis subjects normal pwv visit incident aortic stiffness defined follow pwv results total cohort mean age years chinese malay indian others displayed median annual pwv progression rate adjusted multivariate regression analyses showed baseline age pwv body mass index bmi constantly predicted follow pwv annual pwv progression rate rapid pwv progression incident aortic stiffness paradoxically lower baseline pwv associated elevated annual pwv progression rate rapid progressors inverse relationship remained significant across ethnicities ethnic stratification higher bmi independently predicted pwv progression chinese indians malay others ethnic groups increased age significant predictor chinese others ethnicities conclusions demonstrated baseline bmi modifiable independent risk factor pwv progression incident aortic stiffness therefore better obesity management may impede aortic stiffness singapore tdm patients especially chinese indians published elsevier ireland ltd
net positive concept could serve new direction aspiration evolving sustainable design beyond minimizing human damage toward human habitation source life commentary posits realizing potential depends practitioners define positive describing net positive buildings add value ecological systems generate need fulfil needs moves net positive beyond simply technical challenge creating surpluses one requires confronting widely different interpretations value value adding held within sustainability movement green building like building industry generally defines measures building value terms human benefit ecological sustainability defines value terms benefits systemic capability generate sustain evolve life particular place reconciling different definitions could transform society conceives designs built environment building professionals seeking translate net positive practice could play leading role transformation practice need embrace ecological thinking create design construction ongoing management processes stimulate dialogue means humans play value adding role ecological systems constituents
minimizing working time internal combustion engine important method hybrid electric vehicles save energy reduce emissions however vibrations caused frequent engine starts stops deteriorate driveability ride comfort especially power split hybrid vehicles kinematically decoupled device engine transmission vibrations transfer powertrain car body engine mounts also driveline system hardware test results show longitudinal vibration seat track severe maximum peak peak acceleration study dynamic models driveline system powertrain mounting system respectively established detail natural characteristic analyses two dynamic models reveal engine order vibrations stimulate series low frequency resonances engine starts finally embodied car body vibrations two dynamic models coupled together analyze transient dynamic characteristics associated engine starts evident simulations longitudinal vibration car body mainly transferred driveline whereas vertical vibration car body mainly transferred powertrain mounting system besides initial crankshaft position gasoline engine obvious effect engine order vibration results different transient responses full vehicle system
current study used novel scene paradigm investigate role encoding schemas memory specifically study examined influence strong encoding schema retrieval schematic non schematic information well false memories information associated schema additionally separate roles recollection familiarity veridical false memory retrieval examined study identified several novel results first many common neural regions mediated schematic non schematic retrieval success schematic recollection exhibited greater activation visual cortex hippocampus regions commonly shown mediate detailed retrieval effortful cognitive control regions prefrontal parietal cortices hand supported non schematic recollection lateral temporal cortices supported familiarity based retrieval non schematic items second true false recollection well familiarity mediated activity left middle temporal gyrus region associated semantic processing retrieval schematic gist moreover activity region greater false recollection false familiarity suggesting greater reliance lateral temporal cortices retrieval illusory memories irrespective memory strength consistent previous false memory studies visual cortex showed increased activity true compared false recollection suggesting visual cortices critical distinguishing previously viewed targets related lures retrieval additionally absence common visual activity true false retrieval suggests unlike previous studies utilizing visual stimuli false memories predicated schematic gist perceptual overlap little reliance visual processes false memory retrieval finally medial temporal lobe exhibited interesting dissociation showing greater activity true compared false recollection well false compared true familiarity results provided indication different types items retrieved studied within highly schematic context results replicate extend previous true false memory findings supporting fuzzy trace theory
background compared chemotherapy significant improvement survival outcomes programmed death receptor inhibitors nivolumab pembrolizumab programmed death ligand inhibitor atezolizumab shown several types advanced solid tumors conducted systematic review meta analysis compare safety tolerability inhibitors chemotherapy methods pubmed american society clinical oncology asco databases searched september eligible studies included randomized controlled trials rcts comparing single agent food drug administration approved inhibitors nivolumab pembrolizumab atezolizumab chemotherapy cancer patients reporting grade high grade adverse events aes high grade treatment related symptoms hematologic toxicities immune related aes treatment discontinuation due toxicities treatment related deaths summary incidence relative risk confidence intervals calculated results total patients rcts included meta analysis nivolumab pembrolizumab atezolizumab trials underlying malignancies included non small cell lung cancer trials melanoma trials compared chemotherapy inhibitors significantly lower risk high grade fatigue sensory neuropathy diarrhea hematologic toxicities grade anorexia nausea constipation high grade aes treatment discontinuation increased risk grade rash pruritus colitis aminotransferase elevations hypothyroidism hyperthyroidism high grade pneumonitis inhibitors conclusion inhibitors overall better tolerated chemotherapy results provide evidence supporting favorable risk benefit ratio inhibitors
background childhood obesity concern australia across world community based weight management programs important response address childhood obesity however scientific literature suggests effectiveness could potentially enhanced providing structured incentive scheme proposal aims determine effectiveness enhanced goal setting linked structured incentive scheme designed improve sustained health wellbeing overweight obese children within context existing community based program methods design study cluster randomized controlled trial delivered within context existing nsw gofun program week month follow sites participants compares effectiveness small changes program children asked set goals supported text messages given rewards achieving intervention compared standard existing program control structured incentive program data collected participants baseline end program months primary outcome mean change body mass index bmi score month follow secondary outcomes include anthropometric measures body weight height waist circumference behavioral measures collected via validated questionnaires process evaluation comprising surveys focus groups determine acceptability sustainability inform downstream translation also conducted discussion study inform policy program delivery well broader evidence base regarding goal achievement incentive schemes directed children health related behaviors provide evidence likely transferrable across range health conditions
paper presents design multivariable feedback control compact precision positioner moving stage total mass generate axis motions single frame aerostatic bearings levitate positioner three phase synchronous permanent magnet planar motors spmpms generate electromagnetic forces concentrated field permanent magnet matrix three hall effect sensors measure magnetic flux calculate planar position three laser distance sensors detect vertical displacement real time application interface rtai comedi linux personal computer used real time control single input single output siso digital lead lag controllers axis designed multi input multi output mimo model developed positioner reduced order linear quadratic gaussian lqg controllers applied horizontal positioning several experimental results demonstrate dynamic performance positioner
australia multicultural society however history british colonisation contributed enduring overt covert discrimination racism black white racial divisions aboriginal torres strait islander peoples recipients ongoing racial discrimination disadvantage groups australia significantly overrepresented social work clients anti racist stance core social work practice literature suggested cultivating empathy help reduce racism provoke activism social justice classroom based inquiry exploring barriers activism extended previous student centred research exploring empathy racism findings suggest students hesitant commit action social justice reasons including lack confidence lack time information facilitating social work students confidence increased understanding everyday acts activism skill development including critical empathy may bolster confidence action social justice
objective determine prevalence types intimate partner violence ipv pregnancy factors linked ipv effects ipv maternal fetal outcomes methods prospective observational study tertiary care hospital delhi india women weeks pregnancy screened ipv december april women completed detailed questionnaire followed delivery results overall women experienced ipv pregnancy prevalent type ipv emotional followed physical sexual prevalent factor triggering ipv intimate partner desire son women intimate partners older ipv group control group duration marriage longer multigravidity lower socioeconomic status low education level intimate partner partners addiction common ipv group obstetric outcomes similar groups depression diagnosed women affected ipv conclusion ipv documented approximately participants population based surveys need done investigate
differential diagnosis urticaria angioedema based phenotype either acute chronic depending duration weeks respectively additional subdivisions include poorly defined terms idiopathic spontaneous autoimmune article author suggests increased understanding acquired innate immune system data novel proteomic technology blurred lines categories diagnosis specific molecular pathways response specific medications incorporated classification diagnosis schemes
prebiotics non digestible selectively fermented dietary fibers specifically promote growth one bacterial genera gastrointestinal tract thus provide health benefit host two investigated prebiotics inulin type fructans galacto oligosaccharides prebiotic specificity mediated speciesspecific gene clusters within saccharolytic bacteria controlled signaling sensors various substrates prebiotic health benefits attributed immune regulation bacterial metabolite production humans prebiotic supplementation leads increased growth specific gut microbiota bifidobacteria immune modulation depending bacterial augmentation short chain fatty acid production irritable bowel syndrome crohn disease gastrointestinal disorders associated reductions gut bacteria greater mucosal inflammation prebiotic supplementation studies shown promise low doses modulation gut bacteria reduction symptoms ibs however larger doses may neutral negative impact symptoms studies crohn disease shown benefit bacterial modulation inflammatory response prebiotic supplementation dietary restriction fermentable carbohydrates low fodmap diet restricts naturally occurring prebiotics diet shown efficacy improving symptoms irritable bowel syndrome lowers numbers key gut microbiota research required effect prebiotics gastrointestinal disorders particular use conjunction low fodmap diet
alleging bushman made sensational unsubstantiated claims markey mistake hypotheses hyperbole moreover effort show gun violence movies ages older unrelated trends population violence make unjustified demands data outcomes unconnected hypothesized effects using outcomes line hypotheses draw contrary conclusion recent trends gun violence youth actually consistent gun violence trends movies nevertheless believe patterns sufficient draw causal conclusions suggest adequate tests hypothesis exposure movie gun violence affects beliefs attitudes youth toward guns
williams syndrome rare neurodevelopmental disorder associated hemideletion chromosome manifests distinct behavioral phenotype characterized hyperaffiliative social drive striking contrast social avoidance behaviors common autism spectrum disorder asd mri studies observed structural functional abnormalities cortex including prefrontal cortex pfc region implicated social cognition study utilizes bellugi williams syndrome brain collection unique resource comprises largest postmortem brain collection existence first quantitatively examine pfc cytoarchitecture measured neuron density layers iii five cortical areas pfc areas primary motor primary somatosensory visual area six matched pairs typically developing controls neuron density pfc lower relative layers demonstrating largest decrease density reaching statistical significance contrast demonstrated higher density compared although difference statistically significant neuron density similar cortical areas altered prefrontal areas appeared affected neuron density also altered pfc individuals asd together findings suggest pfc targeted neurodevelopmental disorders associated sociobehavioral alterations autism res international society autism research wiley periodicals inc
human beings manage global virtual teams regularly face challenges caused factors lack shared language culture among team members coordination delay resulting spatial temporal divisions members team part ongoing advances artificial agent technology artificial agents developed whose purpose assist human managers virtual teams paper move step suggesting new capabilities developed artificial agents eventually give ability successfully manage virtual teams whose members human beings particular artificial agents uniquely positioned take roles managers cross cultural multilingual global virtual teams overcoming fundamental cognitive limitations create obstacles human beings serving managerial roles order effectively interact human team members aas must able decode encode full spectrum verbal nonverbal communication used human beings culture deeply embedded human forms communication aas communicate way non cultural capable communicating effectively human team members necessarily display particular culture mix cultures human beings already researchers designed aas display diverse cultural behaviors use language intonation gaze posture emotion personality need team leaders display cultural behavior raises key question culture cultures leader particular human virtual team display argue answer question depends cultural makeup team human members methods used share information among team members facilitate analysis team leader cultural behaviors best structured fit circumstances particular virtual team propose two dimensional model designing suites cultural behaviors aas manage human virtual teams first dimension describes whether deploys cultural behaviors dealings team members objectivity customizes cultural display team member personalization second dimension describes whether always displays culture given team member invariance possesses repertoire cultural guises particular team member chooses one fit current situation situationality two dimensions objective personalized invariant situational cultural behaviors yield four archetypes aas leading virtual human teams consider examples type identify potential strengths weaknesses type suggest particular kinds virtual teams likely benefit managed aas different types discuss empirical study test validity usefulness framework
natural frequencies vibration corresponding mode shapes suspension bridge varying bending stiffness cables determined changes occur characteristics respect parametric changes bridge examined single span suspension steel footbridge hangers flexible cables selected initial model used study dynamic characteristics suspension system based fea parameter studies presented vibration characteristics studied function structural material parameters cable flexural stiffness modulus elasticity mass density structural components generally found main cable bending stiffness contributes considerable effect natural frequencies suspension system
purpose purpose study describe women experiences undergoing total knee joint replacement surgery design qualitative approach used method content analysis text interviews five women conducted findings time surgery marked experience constant pain affected women negatively everyday lives surgery information provided staff gave woman sense security women handed responsibility staff experienced sensation relief postoperative period characterized feeling joy surgery although rough tedious rehabilitation phase began challenges everyday life factor motivation confidence although postoperative pain experienced discouraging conclusion support health care staff important factor coping everyday life preoperative perioperative postoperative phases undergoing knee joint replacement
problems students high mathematical potential far complex challenging problems normally used regular classrooms problems developed mathematically gifted students offer possibility acquiring using heuristics called patterns actions useful problem solving processes kinds capablities valuable students ask whether possible work problems regular classrooms paper two studies presented examine extent students regular classrooms capable working problems designed mathematically gifted students results show problems used support programme also successfully applied regular classroom teaching students working experience high motivation however students support programme achieved better results regarding generalization proving addition needed less time solve problems
serious labor shortages construction industry emerged china recent years led significant need industry improve poor accommodations inferior conditions living quarters migrant workers applying technical management methods order address problem improving accommodations rural migrant construction workers urban china paper uses modular construction technology develop innovative integrated prefabricated prefab accommodation system construction workers site current status traditional construction workers quarters investigated reveal urgent problems terms health safety environmental considerations analyzing barriers block innovation improved workers quarters integrated prefab accommodation system proposed detail quarters design operational management mode taken account developed system provide comfortable accommodations living conditions migrant site workers lower residential density cleaner safer higher quality lifestyle case study real world pilot project china studied validate economic feasibility applicability innovative integrated prefab quarters system results indicate migrant workers pay yuan per day daily income use integrated prefab quarter system developed system provides novel construction management mode practitioners industry increase productivity project due reduced physical mental health problems migrant workers suggested developed system business mode promoted regions large numbers migrant construction workers
offshore wind turbines incorporating electrical generators converters operate locations accessibility lead long mean times repair conditionbased maintenance therefore essential cost effective availability targets reached yet condition monitoring techniques appropriate offshore win turbines resolved reliability studies shown majority failure modes wind turbines concentrated drive train subassemblies including electrical generator converter heavily affected wind conditions test rig constructed features similar wind turbine drive train enable development signal processing techniques necessary variable speed high torque variation application test rig includes low speed shaft high speed shaft gearbox electrical generator driven simulated wind conditions test rig also used inform selection appropriate monitoring instrumentation offshore wind turbines series condition monitoring approaches investigated test rig using measured torque speed shaft displacement gearbox vibration detect faults use appropriate signal processing techniques chances load conditions properties gearbox cod faults detected
paper discusses contradictory imperatives contemporary australian pedagogy notions controversy diversity relate subjects genders sexualities common view gender sexuality important organising features identity society politics consistent effort made australian educational context combat discrimination prejudice sexually gender diverse people however state commitment diversity policies must balanced secondary focus appeasing hostile non heteronormative expression view expression inherently political nature therefore inappropriate school setting australia arguably demonstrated dilemma recently two notable controversies intervention planned school screenings gayby baby documentary exploring experience children sex families media furore trans positive teaching kit using case studies paper explores competing imperatives controversy diversity commenting tendency lives experiences lgbtiq people becoming consequently politicised arguably detrimental meaningful participation lgbtiq people social citizens
article case patient osteocutaneous fistula left malar region secondary impacted spike soccer cleat mandible presented clinical radiologic diagnoses failed obscure anamnesis patient unavailability viewing spike orthopantomogram computed tomography surgical extirpation performed year old man injured football match months presentation swooning history accidental booting early late complications surgery end months study shows importance obtaining definite history patients sequential radiologic imaging make differential diagnosis foreign bodies cystic noncystic tumors inflammatory lesions mandible
multi label learning draws great interests many real world applications highly costly task assign many labels oracle one instance meanwhile also hard build good model without diagnosing discriminative labels reduce label costs improve ability train good model multi label learning simultaneously active learning addresses less training samples problem querying valuable samples achieve better performance little costs multi label active learning researches done querying relevant labels less training samples querying labels without diagnosing discriminative information effectively handle outlier labels measurement uncertainty since maximum correntropy criterion mcc provides robust analysis outliers many machine learning data mining algorithms paper derive robust multi label active learning algorithm based mcc merging uncertainty representativeness propose efficient alternating optimization method solve mcc method eliminate influence outlier labels discriminative measure uncertainty make improvement ability information measurement merge uncertainty representativeness prediction labels unknown data enhance uncertainty also improve similarity measurement multi label data labels information experiments benchmark multi label data sets shown superior performance state art methods
background many adults living residential care demonstrate challenging behaviors nonpharmacological strategies recommended first line treatment using applications apps novel approach managing behaviors yet assessed group paper describes pilot study test apps novel non pharmacological strategy manage challenging behaviors adults living residential care methods non blinded non randomized crossover trial design implemented compared apps control situation usual care determine whether apps able decrease challenging behaviors primary outcome measure neuropsychiatric inventory npi measures frequency severity behaviors results fifteen residents participated whose mean age years range diagnoses comorbidities including dementia schizophrenia ipads used medium delivering apps residential care staff implemented interventions significant decrease total npi score using apps intervention points compared control points usual care points positive qualitative feedback staff involved study also cited barriers lack confidence using apps lack time conclusions although small limited study results suggest using apps may feasible personalized approach managing challenging behaviors rigorous study design includes larger sample sizes staff training may enable research benefits area
background purposechronic cluster headache rare highly disabling primary headache condition medically intractable occipital nerve stimulation offer effective treatment open label series provided data small cohorts methodswe analyzed subjects evaluate long term outcomes highly intractable chronic cluster headache occipital nerve stimulation patients intractable chronic cluster headache implanted occipital nerve stimulators period primary endpoint improvement daily attack frequency secondary endpoints included attack severity attack duration quality life measures headache disability scores adverse events resultswe studied patients males mean age implant range years mean follow range months nineteen patients chronic headache types addition chronic cluster headache final follow improvement attack frequency across patients cluster headache alone multiple phenotypes significant differences response without multiple headache types overall response rate defined least improvement attack frequency significant reductions also seen attack duration severity improvements noted headache disability scores quality life measures triptan use responders dropped resulting significant cost savings adverse event rates highly favorable conclusionoccipital nerve stimulation appears safe efficacious treatment highly intractable chronic cluster headache even mean follow years
develop several parallel algorithms shortest distance queries planar graphs use graph partitioning preprocessing phase precompute store distances selected pairs vertices query phase given pair arbitrary vertices stored information used find distance fast algorithms implemented tested high performance cluster upto core cpus performances analyzed compared
objective study examines impact organizational change psychosocial work environment non disability early retirement among senior public service employees methods january february danish senior public service employees aged years capital region denmark responded survey assessing psychosocial work environment social capital organizational justice quality management work unit organizational changes change management merging demerging relocation recorded january march weekly data non disability early retirement transfer obtained dream register database holds weekly information public benefit payments denmark hazard ratios early retirement following employees birthday estimated cox regression adjusted age gender socioeconomic status results exposure change management confidence interval mergers relocation work unit increased rate nondisability early retirement demerging work unit work units lower levels social capital organizational justice quality management increased rate early retirement conclusion organizational change poor psychosocial work environment contribute non disability early retirement among senior public service employees measured work unit level
herod great appointed king jews govern judea roman emperor senate lived bce died illness symptoms source considerable speculation richard strauss depicted herod classic opera salome opera derived play name oscar wilde based painting salome dancing herod gustave moreau operatic herod afflicted illness characterized dementia hallucinations paranoia alcoholism drinking emperor wine violence twitches sterility different interpretations showed also falls chills shaking thirst forgetfulness sleepiness suggest novel diagnosis chronic lead intoxication manifest rheumatologists saturnine gout compatible symptoms encephalopathy neuromuscular abnormalities consumed excessive quantities imperial wine known highly contaminated lead likely associated similar symptoms among roman aristocracy herod demented cruelties oppressive reign including beheading john baptist exacerbated political climate may contributed subsequent violent year revolt culminating destruction second temple different might history herod great abstemious
patients eating disorders risk electrolyte imbalances lead life threatening complications timely recognition evaluation electrolyte abnormalities including hypokalemia essential case report describe uncommon etiology hypokalemia patient disordered eating society adolescent health medicine rights reserved
introduction non fasting plasma triglyceride remnant cholesterol levels cholesterol content triglyceride rich lipoproteins suggested additional cause cardiovascular diseases thus pharmacological lowering fibrates activators ppar alpha system linked risk reduction areas covered manuscript reviews available evidence clinical trials involving highly selective ppar agonists pemafibrate drugs used pre clinical experimental setting original publications english selected well abstracts international meetings presentations clinical trials identified using clinicaltrial gov database clinical trials register clinicaltrialsregister expert opinion addition aim improving lipid profile fibrates interest new ppar activators stems need overcome clinical problems encountered dose dependent adverse events rise plasma creatinine gallstone formation drug drug interactions gemfibrozil myopathy new ppar agonists improved hdl levels well parameters related metabolism remnant cholesterol apob without raising liver enzymes although use fibrates rated second choice many clinicians new ppar agonists may offer accessible route management hypertriglyceridemia frequent clinical condition
great east japan earthquake occurred march fatally damaged fukushima daiichi nuclear power plant npp caused prolonged station blackout sbo following sbo reactor water level gradually dropped due increase steam discharge safety relief valves eventually led nuclear fuel melt almost four years passed since accident official reports japanese regulatory given general description causes progressions fatal accident even fukushima accident nuclear power plants currently operating units construction worldwide fact alone extremely important learn fukushima accident enhance safety culture reactor operation completely eliminate possibilities catastrophic accidents seen study best estimate transient thermal hydraulics code retran modo utilized focus effectiveness isolation condenser installed advanced boiling water reactors abwr ics turned one operable safety systems fukushima accident simple yet reliable safety system utilized secure abwr possible reactor core damages present paper several case studies conducted utilizing ics presented methods countermeasures improve light water reactor safety level design operation features proposed elsevier ltd rights reserved
paper presents methodology optimization gating system sand casting using genetic algorithm software package computer aided design computer aided manufacturing cad cam used support design verification optimized gating system geometry gating system sand casting excavator tooth holder subject optimization objective maximize filling rate given constraints posed ingate module reynolds number mold filling time presented function ingate cross section casting height given conditions result optimization complete geometry gating system defined numerical simulation software magma used verify validity optimized geometry gating system
carbon based denitrification bioreactors designed intercept tile drainage promising technology reducing export surface water systems tested extensively laboratory ability study field bioreactors controlled conditions statistical replicates limited nine pilot scale bioreactors designed installed systematic field testing allowing variation retention time fill material influent water quality parameters bioreactor constructed concrete trench line influent flow control dosing port flow diffusion effluent water level control sampling ports installed two points bioreactor access water samples fill materials potassium bromide kbr tracer study conducted morrill dispersion index mdi values averaged indicating plug flow characteristics average tracer residence time close agreement estimated hydraulic retention time hrt value calculated using porosity value hydraulic efficiency good lambda evidence short circuiting system expected provide useful insight regarding design improved field performance denitrification bioreactors
according israeli law citizens aged obligated fulfill military reserve duty israeli defense forces idf guided theory conservation resources cor hobfoll study examined association resource loss gain economic time familial work personal resources level reserve combat soldiers distress satisfaction service following termination reserve duty sample consisted male israeli citizens ages serving reserve soldiers idf using internet based questionnaire prior start reserve duty time respondents completed questionnaires assessing psychological traits social support psychological distress following reserve service period time respondents completed short inventory resource loss gain related service assessments psychological distress satisfaction service main results showed resource loss higher average resource gain associated positively distress negatively satisfaction service whereas resource gain positively associated satisfaction findings compatible cor theory point areas reserve soldiers could assisted fulfilling task maintaining national security simultaneously preserving personal well
background budd chiari syndrome bcs rare potentially fatal disease characterized hepatic venous outflow tract obstruction heparin induced thrombocytopenia hit immune mediated complication heparin therapy mortality approaching reported prevalence hit adults expert consensus case reports existing evidence hit bcs knowledge first study formalize anecdotal evidence methods retrospective analysis carried patients presenting tertiary liver centre acute liver failure bcs bcs primary indication liver transplantation prevalence hit study group compared highest reported prevalence adult medical patients receiving heparin mortality length stay liver transplantation rates also studied results bcs patients developed hit significantly higher previously reported prevalence hit medical patients difference mortality length stay liver transplantation rate hit positive hit negative patients conclusion prevalence hit cohort bcs patients significantly higher general population although study powered detect outcome differences heparin mainstay acute bcs treatment represents significant risk recommend high index suspicion hit patients bcs thrombocytopenia appropriate hit testing strategy consideration direct thrombin inhibitors eur gastroenterol hepatol copyright wolters kluwer health inc rights reserved
physicochemical properties anode material important electron transfer anode bacteria electricity generation microbial fuel cells mfcs work carbon cloth anode pretreated isopropanol hydrogen peroxide sodium hypochlorite naocl order reduce anode functional groups influence functional groups electrochemical properties carbon cloth anode power generation mfcs investigated anode pretreatments removed surface sizing layer carbon cloth substantially reduced contents pyridinic pyrrolic groups anode electrochemical impedance spectroscopy cyclic voltammetry analyses biofilm matured anodes revealed enhanced electrochemical electron transfer property anode pretreatments compared untreated control mwm maximum power density acetate fed single chamber mfc increased mwm isopropanol treated anode additional treatment naocl increased maximum power output mwm mwm nearly inverse liner relationship observed contents pyridinic pyrrolic groups anodes anodic exchange current density power output mfcs indicating adverse effect functional groups electricity production anodes results study understanding microbial interaction carbon based electrodes provide important guidance modification anode materials mfcs future studies copyright john wiley sons ltd
personalized exchange atape inspired process speedup parallel distributed computing recently atape algorithms successfully applied multistage interconnection networks mins including baseline butterfly networks however routing algorithms mins relies switch patterns stage control sources half routing solution since perform full self routing protocol mins paper first propose full routing solution realizing atape class nary switch mins baseline butterfly etc atape embedded chip effectively self routing also stage switch control routing two embedded atape functions incorporate multi stage pipelining proposed optimal log default static function xor order mod optional dynamic function rho order mod incrementing counter second introduce crossbar mins fewer delay stages achieve ultimate atape embedding finally experimental results applying atape mins confirmed fruitfully including atape based nxn matrix transposition log yields significant speedup elsevier inc rights reserved
intimate partner violence ipv teen dating violence tdv widespread preventable public health problems united states children exposed ipv caregivers adolescent victims tdv suffer immediate risks physical safety also long term health sequelae emergency department presents unique opportunity physicians screen various forms family violence intervene behalf victims screening ipv tdv widely recommended national health organizations including american college emergency physicians effective screening protocols require multidisciplinary approach informed knowledge local community resources
background among various complications heart transplantation htx vasculopathy allograft cav phenomenon chronic rejection still serious problem recently literature shown low testosterone levels men associated cardiovascular disease study evaluated influence testosterone plasma levels cav development methods studied prospective observational study consecutive male htx patients evaluated may june center subjects underwent accurate medical history collection physical examination biochemical blood tests hormone levels transthoracic doppler echocardiography coronary flow velocity reserve assessment coronary angiogram results htx subjects cav significant lower total testosterone plasma levels nmol free testosterone nmol coronary flow velocity reserve respect cav patients considering patients whole group significant negative relation found free total testosterone plasma levels cardiovascular risk factors cholesterol fasting blood glucose significant linear inverse relation found total free testosterone plasma levels cav grading free testosterone plasma levels independent predictors cav conclusions showed first time influence testosterone plasma levels cav development indirectly increasing traditional risk factors directly probable influence alloimmune response
objective african americans experience high rates type diabetes mellitus self management strategies medication adherence key mitigating negative outcomes article addresses gap literature examining intersections drug abuse histories medication adherence among urban older african americans method depth interview data collected part larger ethnographic study examining subjective experience among urban older adults two representative focal cases selected thematic analysis performed illustrate former illicit drug addicts perceive prescription medication usage results narratives reveal participants displeased take prescription drugs making lifestyle changes reduce medication usage maintain sobriety discussion previous drug abuse complicates medication adherence also significant part older african americans former drug users frame understanding broadly
use duration models well known historical data set families births england period show sampled families adjusted timing births accordance economic conditions well stock dependent children effects larger among lower socioeconomic ranks findings existence parity dependent well parity independent birth spacing england consistent growing evidence marital birth control present pre transitional populations
exercise dependence exd documented several types athletes physically active individuals yet prevalence rates cyclists unknown purpose study examine primary secondary variants exd cyclists cross sectional survey cyclists recruited sea otter classic bike races age years male caucasian completed measures race history exercise dependence eating disorder risk exercise amount prevalence risk primary exd secondary exd majority participants reported symptomatic primary exd high proportion cyclists may experiencing symptoms primary exd exhibit eating disorder risk results may inform coaches therapists risk exercise pathology cyclists
increasing number wireless internet users deployed wireless access points past several years raised importance wireless security issues absolute majority wireless users professionals population unaware wireless security types settings importance wireless security assessment analytics help raising security awareness users increasing skills leading improvement entire security situation paper short overview wireless security assessment history presented methodology tools accurate wireless security assessment including data acquisition processing analysis offered proposed methodology tools used processing wireless scan results two capital cities hungary budapest serbia belgrade possibility access point configuration changes security improvement also investigated research results potential improvements wireless security situation discussed
study develop novel system recover waste heat exhaust passenger car heat exchanger therefore placed exhaust manifold vehicle thermoelectric generators teg installed pipes heat exchanger generate electricity temperature difference hot cold sides teg heat transfer teg analyzed numerically two configurations teg units investigated various exhaust flow rates temperatures overall heat transfer rates exhaust gas teg power capacity system overall heat transfer coefficients system calculated observed power capacity system directly related inlet temperature mass flow rate exhaust gas entering system power generated system improved increase mass flow rate temperature exhaust gas increasing size teg system rises overall heat transfer rate system elsevier ltd rights reserved
standard way answering queries incomplete databases compute certain answers defined intersection query answers complete databases incomplete database represents universally accepted definition correct argue one size fits definition often lead counterintuitive plain wrong results propose alternative framework defining certain answers idea framework move away standard database literature assumption query results given form database object allow instead two alternative representations answers objects defining answers knowledge deduce certainty answers show latter often easier achieve former general certain answers need defined intersection may well contain missing values also show proper choice semantics often reduce computing certain answers either objects knowledge standard query evaluation describe framework general way applicable variety data models test three concrete relational semantics incompleteness open closed weak closed world elsevier rights reserved
paper presents new controlled quantum dialogue cqd protocol based cluster entangled states security analyses indicate proposed scheme secure various well known attacks also collusive attack participants may collude communicate without controller permission compared previous cqd scheme also robust conspiracy attack proposed protocol efficient qubit efficiency hardware requirement
objectiveto evaluate effects parent reported medical home status health care utilization expenditures quality children data sourcesmedical expenditure panelsurvey meps including total children followed years survey study designwe took causal difference differences approach using inverse probability weighting doubly robust estimators study changes medical home status year period affected children health care outcomes analysis adjusted children sociodemographic health insurance statuses conducted sensitivity analyses using alternative statistical methods different approaches outliers missing data accounting possible common method biases principal findingscompared children whose parents reported medical homes years medical homes year lost year significantly lower parent reported ratings health care quality higher utilization emergency care compared children whose parents reported medical homes years medical homes year gained year significantly higher ratings health care quality significant differences health care expenditures utilization conclusionshaving medical home may help improve health care quality children losing medical home may lead higher utilization emergency care
important proportion respiratory illness considered attributable residential dampness mold developing health protective guidelines challenging part unhealthy levels indoor defined using available microbiological measurements review paper explores reported multilevel observation based visual olfactory metrics potential defining unhealthy levels residential many multilevel residential metrics identified health risks generally increased observed increased although metrics seemed complex practical use simple metrics among strongest associations health outcomes available findings suggest feasibility setting observation based thresholds trigger remedial action using improved metrics without microbiological measurements least actual dampness related agents cause illness better quantified additional data would allow setting health protective thresholds precisely also metrics could better reflect hidden strongly emphasizing mold odor demonstrated strong associations health effects
entomopathogenic fungi infect insects via penetration cuticle varies remarkably chemical composition across species life stages fungal infection involves production enzymes hydrolyse cuticular proteins chitin lipids host specificity associated fungus cuticle interactions related substrate utilization resistance host specific inhibitors soil fungus conidiobolus coronatus constantin entomophthorales ancylistaceae shows virulence susceptible species larvae pupae calliphora vicina robineau desvoidy diptera calliphoridae calliphora vomitoria linnaeus lucilia sericata meigen diptera calliphoridae musca domestica linnaeus diptera muscidae resistant adults exposed coronatus quickly perish fungus cultivated weeks minimal medium cell free filtrate activity elastase acetylglucosaminidase chitobiosidase lipase determined used vitro hydrolysis cuticle larvae puparia adults amounts amino acids glucosamine fatty acids released measured incubation effectiveness fungal enzymes correlated concentrations compounds detected cuticles tested insects positive correlations suggest compounds used fungus nutrients whereas negative correlations may indicate compounds responsible insect resistance adult deaths result ingestion conidia fungal excretions
existing research appeal media violence led apparent incongruity violent content tends increase selective exposure media violence often decreases enjoyment experiment used two independent manipulations assess role violence selective exposure enjoyment order examine relationship two program descriptions four prime time television dramas altered create violent nonviolent descriptions episode episodes edited create violent nonviolent versions participants likely choose violent descriptions watch enjoyed nonviolent episodes violent episodes moreover nonviolent episodes rated enjoyable even participants chosen watch violent program description theoretical perspective results suggest need move beyond explaining appeal violence terms increased enjoyment instead explore motivations could driving selective exposure violent content aggr behav wiley periodicals inc
one classic fields computer vision image categorization attracted widespread interests numerous algorithms proposed community many advanced state art however existing algorithms designed without consideration supply computing resources therefore dealing resource constrained tasks algorithms fail give satisfactory results paper provide comprehensive depth introduction recent developments research image categorization resource constraints large portion based work also give brief description elegant algorithms furthermore make investigation recent developments deep neural networks focus resource constrained deep nets
importance conceptualizing dynamics storage driven saturation area connectivity runoff generation central development topmodel similar low parameterized rainfall runoff models contribution show developed year hydrometric data base simulate storage discharge relationships girnock catchment scottish highlands using simple conceptual model catchment unique fisheries reference site atlantic salmon populations monitored since modelling allowed track storage dynamics hillslopes riparian zone groundwater explicitly link non linear changes streamflows landscape storage connectivity dynamics provides fundamental basis understanding landscape riverscape hydrologically connected regulates stream hydraulic conditions directly influence salmonids use model simulate storage discharge dynamics year period fisheries records modelled storage driven connectivity provides ecohydological context understanding dynamics stream flow generation determine habitat hydraulics different life stages salmon population new long term modelling sets variability riverscape fundamental context inter relationships storage landscape stream flow generation provides simple robust framework future ecohydrological modelling site alternative increasingly popular highly parameterized uncertain commercial ecohydrological models also provides wider novel context prerequisite model based scenario assessment likely impacts resulting climate land use change copyright authors hydrological processes published john wiley sons ltd copyright authors hydrological processes published john wiley sons ltd
previous works timed logic tctl extended importants modalities order abstract transient states last less time units modalities extension called tctl delta decidability model checking problem proved appropriate extension alur dill region graph theoretical result support natural implementation due state space explosion problem surprising since even tctl timed logics model checking algorithm implemented tools like uppaal kronos based called zone algorithm data structures like dbms rather explicit sets regions paper propose symbolic model checking algorithm computes characteristic sets tctl delta formulae checks truth values algorithm generalizes zone algorithm tctl timed logics also present complete correctness proof algorithm describe implementation using dbm data structure
despite significant advances materials manufacturing techniques applied sports protective equipment recent years sports injuries due impact contusions particular continue occur paper test methodology aimed collecting data laboratory simulated human human impacts basketball presented study executed three stages data collected human instrumented bag impactor instrumented bag iii impactor instrumented human impacts cases high speed video kinematic motion data capture systems used obtain parameters inbound outbound velocities contact durations resistive ink technology pressure sensing films used estimate parameters pressure distributions peak pressures contact areas impact forces elite level athletes used human trials ensure impact techniques levels representative elite game obtained tolerance impacts similarly representative two common strikes simulated knee thigh elbow rib torso five participants used collect human bag data participants used collect impactor human data three five impacts per scenario performed enable noise averaging importantly likely injury causing outlier capture published elsevier ltd open access license
systems counterclockwise input output dynamics negative imaginary transfer functions arise various applications modeling flexible mechanical structures electrical circuits certain kinds measurements taken paper introduce descriptor systems additional structure state various properties prove algebraic characterizations negative imaginariness terms spectral conditions certain structured matrix pencils purpose also analyze particular boundary cases characterized properties structured kronecker canonical form finally describe method used restore negative imaginary property case lost happens system theoretically negative imaginary transfer function obtained model order reduction methods linearization approximations method illustrated numerical examples elsevier inc rights reserved
background sepsis remains leading cause death intensive care units many deaths sepsis due nosocomial infections patients entered immunosuppressive phase disorder one cause immunosuppression sepsis cell exhaustion mediated programmed cell death interaction ligand studies demonstrated blocking interaction knockout mice inhibitory antibodies reversed cell dysfunction improved sepsis survival study assessed efficacy novel short acting peptide compound inhibits signaling clinically relevant second hit fungal sepsis model methods mice underwent cecal ligation puncture induce peritonitis three days later mice received intravenous injection candida albicans forty eight hours candida infection mice treated compound inactive peptide effect candida infection expression coinhibitory molecules quantitated flow cytometry cells cells natural killer cells natural killer cells nkt effect compound survival also examined results four days fungal infection expressions markedly increased nkt cells septic versus sham operated mice versus nkt versus compared control compound caused fold increase survival conclusions compound significantly improved survival clinically relevant immunosuppressive model sepsis results support immunoadjuvant therapy targeting cell exhaustion lethal disease elsevier inc rights reserved
obesity become pandemic owing obesogenic environment inexpensive calorie dense food technologies structure communities reduce replace physical activity inexpensive nonphysical entertainment excessive emphasis low fat intake resulting excessive intake simple carbohydrates sugar effects greater women owing smaller size extra weight gain pregnancy american adult women obese women responsible three fourths billion dollars excess direct health care expenditures due obesity less likely conceive naturally fertility treatments likely miscarry prematurity complications pregnancies describe many causes including key roles dysbiotic intestinal microbiome plays metabolic derangements accompanying obesity increased calorie absorption increased appetite fat storage genetic causes contributory factors present limited effect isolation numerous health consequences obesity discussed authors itemize ways individual societies mitigate pandemic however individual power society enact change willingness public accept outside intervention frustrate efforts stabilize reverse crisis promising strategies education efforts individuals make responsible choices several times every day protect effectively prevention valuable asset american society reproductive medicine
paper describes novel idea designing fuzzy neural network modeling nonlinear system dynamics presented approach assumes state space representation order obtain compact form model without statement great number parameters needed represent nonlinear behavior increase flexibility network simple takagi sugeno inferences used estimate current system states set multiple local linear state estimators afterwards output network defined function current estimated system parameters simple learning algorithm based two step gradient descent procedure adjust network parameters applied potentials proposed modeling network demonstrated simulation experiments model oscillating pendulum nonlinear drying plant
computer video games especially ego shooter often named causal factor regards school shootings review reflects computer game use debate computer games aggressive behaviour well link computer games school shootings despite literature computer games aggressive behaviour yielding mixed results causal relationship found computer games school shootings influential factors private ownership guns media coverage school shootings need addressed detail ongoing debate
several novel dispersion engineered crlh metamaterial analog signal processing systems exploiting broadband dispersive characteristics design flexibility crlh tls presented systems either guided wave radiated wave systems employ either group velocity group velocity dispersion parameters systems presented frequency tunable impulse delay line pulse position modulator frequency discriminator real time fourier tran former pulse generators analog real time spectrum analyzer frequency resolved electrical gating spatio temporal talbot effect imager analog true time delayer represent new class impulse regime metamaterial structures previously reported metamaterials mostly restricted hormonic regime
direct income supports long known substantially reduce extent depth poverty evidence suggests also bolster children opportunities succeed enhance long term mobility growing body research example links income related tax credits working families earned income tax credit child tax credit benefits children families improved birth weight better school outcomes increased rates employment adulthood similarly introduction food stamps found improve birth weight infants given access program also educational achievement well indicators health wellbeing self sufficiency decades later striking research results income support typically thought improving children health education mechanisms income supports lead benefits likely varied complex emerging research suggests helping families children afford basic necessities reduce added stress financial difficulties preventing downstream neuroendocrine biochemical changes affect children longer term outcomes findings important implications policy makers research suggests potential weakening safety net would substantially increase poverty also damaging long term effects children policy makers reject funding cuts instead strengthen safety net analysis suggests could reduce poverty also enhance children opportunities succeed
dark triad traits including narcissism machiavellianism psychopathy assumed link poor personal morality however increasing number studies suggested narcissism brighter machiavellianism psychopathy sample chinese adolescents relationships among dark triad traits moral identity internalization symbolization prosocial behavior examined results showed narcissism positively related internalization symbolization prosocial behavior whereas machiavellianism psychopathy negatively related internalization prosocial behavior related symbolization positive links narcissism personal morality moderated self esteem links weaker among high self esteem individuals low self esteem ones findings highlighted bright fragile side narcissism discussed cognitive motivational perspectives elsevier ltd rights reserved
aim prediabetes type diabetes highly prevalent among individuals serious mental illness increased antipsychotic medication although widely recommended many obstacles prevent patients obtaining proper screening dysglycemia currently glycated hemoglobin hbac fasting glucose hour glucose levels oral glucose tolerance test used screening prediabetes type diabetes objective study investigate hbac could used screening test among individuals serious mental illness methods cross sectional study comparing sensitivity hbac fasting glucose oral glucose tolerance test detect dysglycemias serious mental illness participants referred metabolic complications results total participants female aged years bmi included regarding prediabetes identified hbac fasting glucose oral glucose tolerance test respectively type diabetes identified hbac fasting glucose oral glucose tolerance test overlap markers low participants prediabetes type diabetes sensitivity hbac moderate range specificity excellent conclusion present study indicates low agreement hbac fasting glucose oral glucose tolerance test appears markers identify participants thus hbac may used alone detect glucose abnormalities among individuals serious mental illness
several studies patients schizophrenia reported marked reduction sleep spindle activity investigate whether reduction may linked genetic risk illness analysed sleep spindle activity healthy volunteers patients schizophrenia first degree relatives share enriched set schizophrenia susceptibility genes investigated correlation spindle activity cognitive function first degree relatives whether spindle abnormalities affect fast slow sleep spindles investigated fast slow sleep spindle activity non rapid eye movement sleep total subjects comprising patients schizophrenia healthy first degree relatives healthy volunteers groups balanced age gender years education estimated verbal subsample relatives received additional testing memory performance compared healthy volunteers fast spindle density reduced patients schizophrenia healthy first degree relatives following pattern consistent assumed genetic load schizophrenia deficit spindle density specific fast spindles associated decreased memory performance findings indicate familial occurrence phenotype thus support hypothesis deficient spindle activity relates genetic liability schizophrenia furthermore spindle reductions predict impaired cognitive function specific fast spindles physiological marker investigated intermediate phenotype schizophrenia could also constitute target drug development especially regard cognitive dysfunction
background denosumab treatment years freedom study extension associated low fracture incidence clear whether subjects discontinued study conduct higher risk fracture remained enrolled thereby underestimating true fracture risk entire trial cohort thus explored influence early withdrawals nonvertebral fracture incidence extension study methods understand potential effect depletion susceptible subjects fracture incidence first evaluated subject characteristics patients enrolled extension subsequently employed kaplan meier multiple imputation kmmi approach consider subjects discontinued remained enrolled increase fracture risk compared participants remaining study results extension enrollees generally similar nonparticipants median age years respectively mean total hip bone mineral density score respectively probability fracture risk fracture risk assessment tool frax freedom baseline major osteoporotic fracture hip fracture respectively assumed doubled fracture risk increase discontinuation kmmi analyses nonvertebral fracture rate estimates marginally higher observed rates crossover group respectively long term group respectively conclusion observation continued denosumab efficacy years treatment robust seem explained depletion susceptible subjects
water fertilizer major factors influence crop productivity dryland farming ridge furrow rainfall harvesting rfrh system known effective planting method improving rainwater utilization suitable fertilizer application rates foxtail millet rfrh planting yet determined examined effects four fertilizer application rates rfrh planting rfrhp traditional flat planting tfp soil water content swc evapotranspiration plant growth grain yield resource use efficiency foxtail millet found rfrhp improved swc swc exhibited decreasing trend fertilizer rate increased generally significant difference among planting patterns compared tfp rfrhp produced slightly higher maximum leaf area dry matter accumulation although differences significant total reduced general improvements harvest index grain yield water use efficiency wue agronomic efficiency net economic benefit foxtail millet responded positively fertilizer economical fertilizer input rate leaf area dry matter accumulation grain yield increased slightly significant difference fertilizer rate increased beyond agronomic efficiency significantly decreased highest economic net benefit achieved rfrhp combined also obtained significantly higher grain yield wue agronomic efficiency compared tfp thus recommend rfrh system high productivity efficient foxtail millet production semi arid areas published elsevier
study aims analysis mental health professionals attitudes reproductive issues among psychiatric patients method problem centered semi structured interviews psychiatric professionals conducted analyzed content analysis methods results outside psychotherapeutic treatment desire children generally assessed less important context mental health care often limited effective birth control regard drug treatment mental health professionals perceive moral concerns lack expertise among professionals individual doubts barriers dealing reproductive issues discussion order meet psychiatric patients reproductive needs perceptions barriers amongmental health professionals dealing reproductive issues reflected discussed recommendations could support professionals help ensure adequate support psychiatric patients
study tests theory vivid media violence exploring whether presence blood violent game use headphones impacts emotions frustration fear anxiety level cognitive elaboration results experiment suggest participants felt stronger negative emotions playing bloody game headphones video game bloody headphones affect emotions addition frustration related cognitive elaboration whereas fear anxiety implications research exploring discrete emotions well intersection auditory visual features video games discussed elsevier rights reserved
background variations genes regulate innate immunity responses may associated susceptibility asthma atopy early life bronchiolitis aim study evaluate association four different polymorphisms gene either alone combination post bronchiolitis asthma allergies years age methods data single nucleotide polymorphisms snp available children polymorphisms associations asthma allergies studied preschool aged children hospitalized bronchiolitis age months parents interviewed record children history asthma allergies infancy present results years mean asthma present children recurrent wheezing first years life present children fifty three study participants current atopy atopic eczema allergic rhinitis eight children combination current atopy genotype combinations twenty three children rsc rsc genotype present atopy versus genotypes years years age ata haplotype carriers asthma versus haplotype carriers conclusions polymorphisms seem associated elevated allergies recurrent wheezing risk later childhood early life bronchiolitis wiley periodicals inc
rapid development social networks intelligent sensors mobile solutions internet things led emergence large data sets efficiently effectively exploring data sets challenging question especially imperfectness realworld needs taken account objective paper thus propose several solutions modelling representing implementing imperfect information within large fuzzy databases specifically paper imperfect information modelled series generic fuzzy data types uniformly represented means possibility distributions implemented using basic constructs object databases solutions particularly useful exploring large fuzzy databases since permit minimise space required store imperfect information access efficiently effectively databases
pathogenetic heterogeneity pulmonary fibrosis yields challenges opportunities therapy complexity implicates variety cellular processes signaling pathways genetics drivers disease tgf beta stimulation one avenue central pro fibrotic protein expression leading decreased pulmonary function report recent findings introducing ligase fibrosis inducing ligase nem important regulator tgf beta signaling selective degradation pias fiel exacerbates bleomycin induced murine pulmonary fibrosis silencing attenuates fibrotic phenotype developed small molecule inhibitor fiel inhibits degradation pias ameliorates fibrosis murine models new understanding pathway illustrates many targeting opportunities among complexity pulmonary fibrosis continuing search therapy elsevier ltd rights reserved
ecological success social insects including ants tightly connected ability protect food resources exchange energy rich honeydew ants protect myrmecophilous aphids various natural enemies fungal infection disastrous consequences mutualist partners wherein aphids disease vectors behavioural responses towards fungus infected aphids ant species nature scarcely studied studied behaviour honeydew foragers four ant species formica polyctena foerster formica rufa formica pratensis retzius hymenoptera formicidae formicini lasius niger formicidae lasiini towards symydobius oblongus von heyden aphids contaminated generalist fungal pathogen beauveria bassiana balsamo crivelli vuillemin field aphid milkers formica spp quickly detected removed infected aphids host plant betula pendula roth betulaceae neither ant species degree aphid milker specialization medium high number honeydew foragers significant effects behaviour formica milkers towards infected aphids unlike formica ants niger usually displayed non aggressive behaviour tolerance antennation honeydew collection grooming immediate removal infected insects formica ants seem minimize probability infection symbionts well quarantining behaviour may play important role ant aphid interactions preventive antifungal mechanism formed parasite pressure thus contributing ecological success ants
introduction self determination theory explores process person acquires motivation initiate new behaviours related health maintain time study aimed determine overall fit self determination theory model health behavior data obtained sample smokers hospitalized acute coronary syndrome identify predictors smoking status six months clinical discharge material methods sample included participants regular smokers hospitalized due acute coronary syndrome questionnaires administered assess autonomous self regulation perceived competence family support depressive symptoms meaning life participants asked currently smokers six months clinical discharge results results showed process variables specified self determination theory fit data well perceived competence predicted abstinence smoking six months clinical discharge discussion findings similar characteristics international samples self determination theory models tested important facilitate perceived competence patients continue smoke shorter length life conclusion study highlights importance considering clinical interventions based self determination theory facilitate smoking cessation
despite wealth knowledge neural mechanisms behind emotional facial expression processing little known relate individual differences social cognition abilities studied individual differences event related potentials erps elicited dynamic facial expressions first assessed latent structure erps reflecting structural face processing allocation processing resources reflexive attention emotionally salient stimuli early posterior negativity epn late positive complex lpc estimated brain behavior relationships erp factors behavioral indicators facial identity emotion processing abilities structural models revealed participants formed faster structural representations neutral faces shorter latencies performed better face perception memory amplitude related individual differences face cognition emotion processing latent epn factor correlated emotion perception memory also face perception abilities interestingly latent factor representing difference epn amplitudes two neutral control conditions chewing blinking movements also correlated emotion perception highlighting importance tracking facial changes perception emotional facial expressions lpc factor negative expressions correlated memory emotional facial expressions links revealed latency strength activations brain systems individual differences processing socio emotional information provide new insights brain mechanisms involved social communication
aim paper assess discrimination power novel ultrasound parameter called fragility score early identification subjects prone osteoporotic fractures total female patients recruited recent osteoporotic fracture frail subjects controls without fracture history non frail subjects patients underwent spinal dxa dual ray absorptiometry abdominal scan lumbar vertebrae acquired data analyzed novel algorithm calculated spectral statistical analyses involving echo graphic images corresponding raw signals showed good performance discriminating frail non frail subjects sensitivity specificity resulting even slightly effective dxa measured bmd sensitivity specificity methodology potential become effective tool early identification timely treatment frail subjects elsevier ltd rights reserved
species genus garcinia belonging family clusiaceae traditionally known treatment ulcer gonorrhea leucorrhoea abdominal pain genus also reported rich source xanthones benzophenones flavonoids biflavonoids triterpenes showing significant pharmacological activities garcinia mangostana mangosteen garcinia hombroniana pierre seashore mangosteen evergreen tropical trees grown malaysia indonesia thailand tropical countries fruits mangostana queen fruits roots leaves decoction hombroniana commonly used skin allergies infections childbirth trauma diarrhea study aimed evaluate bark fruit extracts mangostana hombroniana phytochemicals analysis total phenolic flavonoid contents antioxidant anti hyperglycemic antituberculosis activities total phenolic contents evaluated folin ciocalteu reagent colorimetric method antioxidant activities radical scavenging assays diphenyl picrylhydrazyl dpph azino bis ethyl benzthiazoline sulphonic acid abts ferric ion reducing antioxidant power frap used antihyperglycemic activity determined using glucosidase amylase enzymes quantitative phytochemical analysis extracts mangostana showed significantly higher content phenolics gae gallic acid equivalent per gram ethyl acetate bark carbohydrates aqueous fruit reducing sugars aqueous fruit also antioxidant activities mangostana showed comparatively high activities ethyl acetate extract potent showing dpph abts frap assays mangostana also potent anti hyperglycemic properties alpha glucosidase alpha amylase compared hombroniana antituberculosis study ethyl acetate extracts plants showed equipotent activity minimum inhibitory concentration mic based results concluded presence bioactive phytochemicals may responsible traditional uses treatment diseases
automat layout detection color yarns necessary weaving producing processes yarn dyed fabrics study presents novel approach inspect layout color yarns double system melange color fabrics automatically part iii series studies develop computer vision based system automatic inspection color yarn layout yarn dyed fabrics inspection single system melange color fabrics realized part series studies integrating projection based region segmentation method proposed part fcm based stepwise classification method proposed part proposed approach composed three steps fabric region segmentation fabric region selection layout color yarns recognition first step fabric regions segmented projection based region segmentation method second step reasonable fabric regions selected analyzing color histograms comparing weft color frequency third step layout color yarn recognized fcm based stepwise classification method precise layouts color warps wefts produced experimental analysis proved proposed method recognize layout color yarns double system melange color fabrics correctly testing four different color fabrics three pieces yarn dyed fabrics wiley periodicals inc
children scotland subject child protection interviews interviewed jointly specially trained police officers social workers attended training based national curriculum study conducted two strands explores effectiveness training focusing specifically free narrative phase interview strand explores respondents self evaluation obtained semi structured interviews participants strand comprises analysis role play interviews findings show considerable discrepancy perceived practitioner confidence ability actual skill levels observed role plays interviewers showed persistent overuse specific closed questions neglecting use open prompts open questions encourage free narrative study concludes national curriculum effective preparing participants free narrative phase interview perceived participants possible reasons explored copyright john wiley sons ltd
order get unbiased parameter estimation transfer function noisy input output data paper presents auxiliary model based method basic idea replace unmeasurable outputs information vector system auxiliary model outputs modify recursive least squares parameter estimation errors system output auxiliary model output proposed method improves precision parameter estimates wide application modelling control engineering without strict mathematical assumption finally advantages proposed approach shown simulation tests elsevier inc rights reserved
study assess porosity porous asphalt concrete pac conjunction medical ray computed tomography facility pac designed surface course achieve target porosity graded aggregates soils blended coarse sand crushed gravel wrapped geotextile compacted served base subbase infiltration layers underneath pac test site constructed located northern taiwan daily traffic light limited porosity test track investigated permeability coefficient pac found severely degraded sec nine year service permeability surface course remained intact several field pac cores drilled brought evaluate distribution air voids medical ray nondestructively helical mode set administrate ray scan two cross sectional virtual slices exported seconds analyzing air voids distribution shows clogging voids occurred merely surface porosity reduce much also found roller compaction decrease porosity permeability reduction test site attribute voids pac compacted roller construction filled dusts surface service
mean age world population steadily increased last decades result increased life expectancy reduced birth rate global aging led greater worldwide cost healthcare hormonal alterations contribute pathogenesis several conditions might cause significant reduction perceived sense well menopause archetypal hormonal alterations occurring aging males sex hormones decrease abruptly yet testosterone levels decrease steadily continuously aging ultimately resulting late onset hypogonadism treatment condition might mitigate symptoms however testosterone replacement therapy trt prescribed selected patients considered antiaging treatment recent years different authors questioned health risks associated testosterone treatment position statements many scientific societies seem reassuring food drug administration issued warning regard possible side effects therapy aim review recent controversies discoveries regard trt
introduction despite number injury prevention campaigns interventions horse riding continues dangerous activity resulting accidents per hour motorcycling skiing football injuries often serious one four patients requiring admission hospital study aims describe severity equestrian related injuries eris using clinical parameters patient reported outcomes patients methods retrospective study patients aged years admitted alfred hospital january january eri performed specific clinical data extracted medical record addition questionnaire conducted identifying details accident required recovery time levels ongoing pain physical disability results study period patients met inclusion criteria three deaths eighty two patients suffered head injuries forty one patients admitted icu patients required mechanical ventilation discharge patients required transfer sub acute rehabilitation facility one hundred twenty four patients completed questionnaire thirty nine respondents wearing helmet among patients injured months still experienced moderate severe pain disability ninety five patients returned work time review among required longer months recover returned reduced capacity conclusions clinical patient reported outcomes eris requiring hospital admission poor persistent pain disability common even years post injury large proportion patients required longer months return work many return reduced capacity elsevier ltd rights reserved
millions people affected respiratory diseases leading significant health burden globally current insufficient knowledge underlying mechanisms lead development progression respiratory diseases treatment options remain limited overcome limitation understand associated molecular changes noninvasive imaging techniques pet spect explored biomarker development fdg pet imaging studied quantification pulmonary molecular imaging data remains challenging variations tissue air blood water fractions within lungs proportions components differ depending lung disease therefore different quantification approaches proposed address variabilities however standardized approach developed date article reviews data evaluating fdg pet quantification approaches lung diseases focusing methods account variations lung components interpretation derived parameters diseases reviewed include acute respiratory distress syndrome chronic obstructive pulmonary disease interstitial lung diseases idiopathic pulmonary fibrosis based review prior literature ongoing research discussions among authors suggested considerations presented assist interpretation derived parameters approaches design future studies
eosinophilic myeloproliferative syndrome ems aggressive neoplasm driven translocation fibroblast growth factor receptor often transforms leukemias lymphomas refractory treatment first case identified date cases reported literature despite reports consensus exists management condition inconsistency treatment regimens even pronounced pediatric literature report case male infant ems review published pediatric experience ems discuss treatment strategies enigmatic hematological disorder
speckle imaging method useful monitoring blood flow living bodies proposed far method simultaneous imaging blood flow blood concentration change using laser speckle patterns two wavelengths however conventional measurement system difficulty adjusting illuminating optical axis two laser sources therefore introduce novel arrangement using coaxial fiber illumination detection speckle patterns two wavelengths arrangement blood flow stably analyzed frame rate using estimation parameter proposed authors based spatial contrast speckle patterns parameter useful estimating autonomic nervous function reflects stress conditions caused tension excitement study present measurements blood flow blood concentration change fiber illumination application estimation stress condition
patient year old japanese male visited nihon university dental hospital refabrication mandibular implant supported complete fixed prosthesis iscfpd maxillary complete denture fabricated years previously case tzp alo nanocomposite tzp applied framework mandibular iscfpd maxillary complete denture three years deliver framework particularly notable biological prosthetic complications observed high level patient satisfaction achieved discussion conventional iscfpd frameworks fabricated casting gold alloys however recent advancement cad cam technology titanium yttria tetragonal zirconia polycrystal tzp frameworks become common contrast main fabrication method frameworks removable dental prostheses shifted conventional casting method cad cam fabrication tzp chosen framework material time shows higher strength greater toughness tzp however since low light transmitting property exhibits opaque white color range application fixed prostheses particularly esthetic area limited conclusion described case tzp applied frameworks mandibular iscfpd maxillary complete denture particularly notable biological prosthetic complications observed mandibular iscfpd maxillary complete denture high level patient satisfaction achieved medium long term observations greater number cases essential obtain information concerning various phenomena related procedure japan prosthodontic society published elsevier ltd rights reserved
background risk indoor exposure volatile organic compounds purported microbial origin childhood symptoms wheezing rhinitis eczema doctor diagnosed asthma rhinitis eczema respectively remain unclear objective test hypotheses total sum microbial volatile organic compounds sigma mvocs poses independent risk doctor diagnosed asthma rhinitis eczema respectively well multiple symptom presentation minimum two conditions case associated significant interaction absolute humidity additive scale methods case control investigation cases controls examined november march period homeindoor air sampling air quality inspection health outcome ascertainment results sigma mvocs also global mvoc index significantly higher within homes cases high compared controls low cases controls associated dose dependent increase exposure variables interest sigma mvocs per quartile increase cases controls among children live high homes natural log unit sigma mvocs associated times greater odds case status compared times odds outcome among low homes specifically joint exposure high mvocs high associated times greater odds doctor diagnosed asthma status conclusion joint occurrence high sigma mvocs associatedwith significant increase case status asthma risks additive scale elsevier ltd rights reserved
one important mosquito borne viral diseases dengue infection becoming global concern due rapid spread rise incidence currently approved vaccine effective antiviral drug dengue virus denv infection glycyrrhetinic acid gna related derivatives reported inhibit broad spectrum viruses however unknown whether carbenoxolone disodium cbx one gna derivatives affects denv infection found production infectious denv particles significantly decreased cbx treatment denv permissive cells viral rna viral protein synthesis affected moreover results time addition study showed inhibitory effect cbx denv exhibited targeting virus host cells directly incubating denv cbx resulted remarkable reduction virus titer virus infectivity furthermore denv rna progeny virions supernatants significantly decreased cbx treatment dose dependent manner taken together data indicate antiviral activity cbx denv may mainly due virucidal effect exerted compound work first time demonstrates cbx antiviral activity denv infection providing useful information development potential therapeutic interventions dengue wiley periodicals inc
fortunately serious injuries cervical spine athletes rare injuries self limited related sprains strains although radiographs may used screen fractures potentially serious soft tissue injuries require additional diagnostic techniques cases advanced imaging computed tomography magnetic resonance imaging mri important assess injury determine treatment prognosis mri well suited imaging cervical spine evaluate injuries article reviews cervical spine imaging athlete emphasis mri groups pathology stability impingement impairment discusses causes radioogical assessment group
personality traits patterns thought emotion behavior relatively consistent time across situations judging traits others oneself ubiquitous consequential activity daily life raises two important questions first accurate personality judgment happen according realistic accuracy model ram accuracy judgments achieved relevant behavioral information available detected judge utilizes information correctly second personality judgments accurate ram identifies four principal moderators accurate personality judgment properties target judgment trait judged information upon judgment based quantity quality individual making judgment people usually manage make personality judgments accurate enough navigation complex social world research accuracy seeks understand happens
recent development system identification using bayesian models stochastic filtering provides probabilistic descriptions probability density function statistical parameters like mean variance identified model parameters mass stiffness damping optimal design passive controllers systems whose parameters uncertain remained open problem view present study aims develop numerical solution scheme optimal design tuned mass damper tmd operating uncertain environment deterministic design tmd cases suffers detuning system parameters random thus reliability based design optimization rbdo scheme presented paper better performance tmd exposed uncertainties solve rbdo problem response surface methodology used along moving least squares technique dual response surfaces used separate handling optimization reliability analysis first response surface performs optimization design variables tmd second response surfaces used estimation statistical properties like mean variance satisfy constrained conditions numerical analysis presented show effectiveness proposed algorithm rbdo single degree freedom tmd system proof concept proposed meta model based algorithm applied optimal design controller large structures conventional technique may face difficulty handle optimization uncertainty quantification simultaneously copyright john wiley sons ltd
well known clustering algorithm fuzzy means fcm allows input sample belong one cluster providing flexibility non fuzzy clustering methods however accuracy fcm subject false detections caused noisy records weak feature selection low certainty algorithm cases false detections important decision making application domains like network security medical diagnosis weak decisions based false detections may lead catastrophic outcomes mainly emerge making decisions subset records provide sufficient evidence make good decision paper propose method detecting ambiguous records fcm introducing certainty factor decrease invalid detections approach enables send detected ambiguous records another discrimination method deeper investigation thus increasing accuracy lowering error rate records still processed quickly low error rate preventing performance loss common similar hybrid methods experimental results applying proposed method several datasets different domains show significant decrease error rate well improved sensitivity algorithm
interpersonal impression formation highly consequential social interactions private public domains perceptions others rely different sources information processing mechanisms investigated independent research fields social psychology inferences states traits others well activations semantic categories corresponding stereotypes attracted great interest hand research emotion reward demonstrated affective motivational influences social cues observer turn modulate attention categorization evaluation decision processes inferential categorical social processes shown recruit network cortical brain regions associated mentalizing evaluation affective influence social cues linked subcortical areas play central role detection salient sensory input reward processing order extend existing integrative approaches person perception inferential categorical processing information others affective motivational influences information beholder taken account
present work aims investigating toxoplasma gondii gondii infection may linked methyl aspartate receptor nmdar dysfunction schizophrenia related disorders puts forward hypothesis immune responses gondii may involve nmdars indeed analysis protozoan proteome nmdar subunits peptide commonalities shows massive peptide overlap supports possibility anti gondii immune responses raised active protozoan infection may cross react host nmdars determining disruption neural circuits cognitive deficits particular nmda subunit mainly expressed parvalbumin positive interneurons appears hotspot potential gondii induced cross reactive immune attacks
immune checkpoint molecules function system checks balances enhance inhibit immune responses infectious agents foreign tissues cancerous cells immunotherapies target immune checkpoint molecules particularly inhibitory molecules programmed cell death cytotoxic lymphocyte associated protein ctla revolutionized human oncology recent years yet little known key immune signaling molecules species primates rodents tasmanian devil facial tumor disease caused transmissible cancers resulted massive decline wild tasmanian devil population recently demonstrated inhibitory checkpoint molecule upregulated tasmanian devil sarcophilus harrisii facial tumor cells response interferon gamma cytokine could play role immune evasion tumor cells performed thorough comparative analysis checkpoint molecule protein sequences among tasmanian devils eight species report many key signaling motifs ligand binding sites checkpoint molecules highly conserved across estimated million years evolution since last common ancestor placental non placental mammals specifically discovered ctla mypppy ligand binding motif ctla gvyvkm inhibitory domain completely conserved across nine species used comparative analysis suggesting function ctla likely conserved species also found cysteine residues intra intermolecular disulfide bonds also highly conserved instance cysteine residues involved disulfide bonds human molecule also present devil although many key sequences conserved also identified immunoreceptor tyrosine based inhibitory motifs itims immunoreceptor tyrosine based switch motifs itsms genes protein domains previously reported species checkpoint molecule analysis review salient features molecules presented serve road map development tasmanian devil facial tumor disease immunotherapy finally strategies used guide veterinarians ecologists researchers willing venture nascent field wild immunology
vario scale data structures designed support gradual content zoom progressive transfer vector data use arbitrary map scales focus date server side especially convert geographic data proposed vario scale structures means automated generalisation paper contributes ongoing vario scale research focusing client side communication particularly works web services setting claimed functionalities urgently needed many web based applications desktop mobile require gradual content zoom progressive transfer high performance level web client prototypes developed paper make possible assess behaviour vario scale data determine users actually see interactions several different options web services communication architectures possible vario scale setting options analysed tested various web client prototypes respect functionality ease implementation performance amount transmitted data response times show vario scale data structure fit current web based architectures efforts standardise map distribution internet however maximise benefits vario scale data client needs aware structure client needs map refined means gradual content zoom operation missing data requested data sent incrementally client server way amount data transferred one time reduced shortening transmission time addition conceptual architecture aspects many implementation tooling design decisions play also elaborated paper based experiments conducted conclude vario scale approach indeed supports gradual content zoom progressive web transfer vector data big step forward making vector data arbitrary map scales available larger user groups international society photogrammetry remote sensing inc isprs published elsevier rights reserved
paper presents application particle swarm optimization designing electrical circuits basis frequency characteristics particle swarm population based global optimization algorithm inspired behavior flocks birds insect swarming algorithm applied optimization approach synthesis electric circuits basis required frequency characteristics usefulness algorithm shown example designing electrical filter humidity sensor model results prove practical suitability pso optimization problems many minima
growing evidence suggests positive mental health wellbeing protects psychopathology flourish derive resilient outcomes however unknown exploratory study investigated self compassion continuously provides friendly accepting situational context negative experiences functions resilience mechanism adaptive emotion regulation strategy protects psychopathology high levels positive mental health participants general population provided measures one time point positive mental health mhc self compassion scs psychopathology hads negative affect mdes self compassion significantly mediated negative relationship positive mental health psychopathology furthermore higher levels self compassion attenuated relationship state negative affect psychopathology findings suggest especially individuals high levels positive mental health possess self compassion skills promote resilience psychopathology might function adaptive emotion regulation strategy protect activation schema related psychopathology following state negative affective experiences enhancing self compassion promising positive intervention clinical practice impact psychopathology reducing factors like rumination self criticism also improve positive mental health enhancing factors kindness positive emotions may reduce future risk psychopathology
piezoelectric actuators smart material actuator applied fields need high precision fast response high force jet dispensing heads generally driven pneumatics require mentioned characteristics make jet dispensing head driven piezoelectric actuators essential use piezoelectric actuators must used displacement amplification mechanism due low displacement generated piezoelectric actuators hence fabricated displacement amplification mechanism using three piezoelectric actuators experiments carried investigate amplified displacements amplification ratio effects produced increasing input frequency study observed characteristics displacement amplifier experimentally confirmed concluded results input frequency increases effect phase lag becomes conspicuous
paper novel transmitting scheme multiple input multiple output mimo satellite relay based multi user multi beam communications proposed considered multiple terrestrial relay nodes employ amplify forward relaying intend improve reliability spectral efficiency satellite radio links zero forcing minimum mean square error mmse signal detection techniques employed well established terrestrial wireless communication systems numerical results provided quantify performance gain proposed system configuration terms bit error rate ber channel capacity
targeted protein degradation using protac technology emerging novel therapeutic method address diseases driven aberrant expression disease causing protein protac molecules bifunctional small molecules simultaneously bind target protein ubiquitin ligase thus causing ubiquitination degradation target protein proteasome like small molecules protacmolecules possess good tissue distribution ability target intracellular proteins herein highlight advantages protein degradation using protacs provide specific examples degradation offers therapeutic benefit classical enzyme inhibition foremost protacs degrade proteins regardless function includes currently undruggable proteome comprises approximately human proteins beneficial aspects protein degradation include ability target overexpressed mutated proteins well potential demonstrate prolonged pharmacodynamics effect beyond drug exposure lastly due catalytic nature pre requisite ubiquitination step exquisitely potent molecules high degree degradation selectivity designed impressive preclinical vitro vivo protac data published data propelled development clinically viable protacs molecular weight falling range delivery bioavailability protacs remain largest hurdles way clinic solving issues demonstrating proof concept clinical data focus many labs next years elsevier inc rights reserved
cell migration across blood brain barrier bbb crucial step pathogenesis experimental autoimmune encephalomyelitis eae animal model multiple scle rosis two photon intravital microscopy ivm established powerful tool study cell cell interactions inflammatory eae lesions living animals eae central nervous system inflammation strongly pronounced spinal cord organ ivm imaging technically challenging limited lumbar spinal cord describe novel spinal cord window preparation allowing use ivm image immune cell interactions cervical spinal cord microvascular endothelium eae describe differences angioarchitecture cervical spinal cord versus lumbar spinal cord entail different hemodynamic parameters different vascular beds using cells example demonstrate suitability novel methodology imaging post arrest multistep cell extravasation across cervical spinal cord microvessels novel methodology includes outlook analysis cellular pathway cell diapedesis across bbb establishing visualization endothelial junctions vascular bed
hybrid surgery coupling total disc replacement fusion increasingly applied multilevel cervical disc diseases cdd however selection optimal disc prosthesis individual patient investigated study aimed distinguish biomechanical performances five widely used prostheses bryan prodisc pcm mobi discover treatment level cdd finite element model healthy cervical spine developed five models using different disc prostheses constructed arthrodesis arthroplasty first rotational displacements flexion extension axial rotation lateral bending healthy model moments combined follower load achieved maximum rotations direction combined follower load applied surgical models following displacement control testing protocols range motion rom entire operative adjacent levels close healthy spine ball socket prostheses prodisc mobi discover bryan pcm rom operative levels less healthy spine resulted increase roms adjacent levels ball socket prostheses produced similar reaction moments close healthy spine meanwhile bryan pcm required greater moments adjacent intradiscal pressures idps models ball socket prostheses close healthy spine meanwhile models bryan pcm adjacent idps higher ball socket models maximum facet stress model mobi greatest among prostheses approximately two times healthy spine moreover bryan produced largest stress bone implant interface followed pcm mobi prodisc discover disc prosthesis biomechanical advantages disadvantages selected individual patient basis general prodisc mobi discover produced similar performances terms spinal motions adjacent idps driving moments whereas bryan pcm produced similar biomechanical performances therefore discover bryan pcm may suitable patients potential risk facet joint degeneration whereas prodisc mobi discover may suitable patients potential risk vertebral osteoporosis
polycythaemia vera myeloproliferative neoplasm classically characterized erythrocytosis associated high risk thromboembolic events constitutional symptoms burden risk transformation myelofibrosis acute myeloid leukaemia therapy directed haematocrit hct reduce risk thrombotic events usually comprises low dose aspirin phlebotomy maintain hct frequently addition cytoreductive therapy indicated high risk patients normalizing haematological parameters mitigate occurrence thromboembolic events unfortunately clear evidence current therapies reduce risk transformation myelofibrosis risk therapy related complication unknown example leukaemia due hydroxycarbamide first line therapy treating remains interferon latter often younger patients especially childbearing age however therapy related intolerance resistance common feature results limited treatment options patients discovery jak mutation consequently targeted therapy janus kinase inhibitors particular ruxolitinib extended spectrum agents used second third line findings phase trial response preliminary data response trial identified role ruxolitinib patients resistant intolerant article using clinical cases demonstrate experience ruxolitinib highlighting clinical benefits limitations encountered clinical practice
neonicotinoids considered safe low affinities mammalian nicotinic acetylcholine receptors nachrs relative insect nachrs however importance nachrs mammalian brain development remains need establish safety chronic neonicotinoid exposures regards children health examined effects long term days low dose exposure neuron enriched cultures neonatal rat cerebellum nicotine two neonicotinoids acetamiprid imidacloprid immunocytochemistry revealed differences number morphology immature neurons glial cells group versus untreated control cultures however slight disturbance purkinje cell dendritic arborization observed exposed cultures next performed transcriptome analysis total rnas using microarrays identified significant differential expression fold control cultures versus nicotine acetamiprid imidacloprid exposed cultures genes respectively common exposed groups nine genes essential neurodevelopment suggesting chronic neonicotinoid exposure alters transcriptome developing mammalian brain similar way nicotine exposure results highlight need careful investigations effects neonicotinoids developing mammalian brain
background paper explores differing perspectives recovery care people disordered eating consider views sought help disordered eating given diagnosis engaged health care services aim demonstrate importance cultural context care might shape people perspectives recovery openness receiving professional care method study utilised mixed methods approach ethnographic fieldwork psychological evaluation women adelaide south australia semi structured interviews observations field notes eating disorder examination primary forms data collection data analysed using thematic analysis results discussion participants study described disordered eating afforded safety consistent cultural values concerning healthy eating gendered bodies disordered eating viewed form self care people protect take care subjectively experienced understandings care underlie eating disorder behaviours provide obstacle seeking form treatment might lead recovery conclusion shared understanding patients health professionals function eating disorder may avoid conflict provide pathway treatment results suggest construction care patients taken granted therapeutic guidelines discussion considering disordered eating practices embedded matrix care health eating body practices may enhance therapeutic relationship
objectives multiple sclerosis common neurological disorders young adults affects central nervous system myelin oligodendrocytes results disability study aimed identify key mirnas blood patients better understanding underlying mechanisms methods publicly available gene expression omnibus data setsof performed integrated analysis mirna expression mrna expression analyzed whole blood samples patients healthy controls microarray analysis gene ontology enrichment analyses kyoto encyclopedia genes genomes pathway analyses construction mirna mrna interaction network quantitative real time polymerase reaction results patients microarray analysis identified significantly dysregulated mirnas significantly dysregulated mrnas negative correlation pairs mirna mrna predicted used construct interaction network hsa mir hsa mir hsa mir hsa mir occurred central hubs regulating genes dysregulated mrnas significantly enriched ribosome tuberculosis pathways cancer verification qrt pcr displayed hsa mir significantly regulated target genes rac regulated tendency hsa mir regulated tendency corresponding target gene eifebp regulated tendency compared healthy controls discussion hsa mir hsa mir hsa mir hsa mir might key participant pathophysiology involved signaling pathways including ribosome tuberculosis pathways cancer
effect hmscs gfp transplantation evaluated experimental model parkinson disease wistar rats three experimental groups control con injured les transplanted les order evaluate influence transplantation motor behavior one month injury rotation behavior induced apomorphine neurological test transversal bar snpc cells positive developed using anova test decrease number turns transplanted animals well neurological test transverse bar lead group intermediate position regarding les con groups possible recovery transplantationmediated nigroestriatal pathway hmsc gfp
paper presents software framework established facilitate cloud hosted robot simulation framework addresses challenges associated conducting task oriented real time robot competition defense advanced research projects agency darpa virtual robotics challenge vrc designed mimic reality core framework gazebo simulator platform simulate robots objects environments well enhancements made vrc maintain high fidelity simulation using high degree freedom multisensor robot major component used cloudsim tool designed enhance automation robotics simulation using existing cloud technologies results vrc discussion also detailed work note practitioners advances robot simulation cloud hosted infrastructure web technology made possible accurately efficiently simulate complex robots environments remote servers providing realistic data streams human loop robot control paper presents software hardware frameworks established facilitate cloud hosted robot simulation addresses challenges associated conducting task oriented robot competition designed mimic reality competition spurred innovation vrc precursor darpa robotics challenge teams around world utilized custom human robot interfaces control code solve disaster response related tasks simulation winners vrc received funding access atlas humanoid robot developed boston dynamics gazebo simulator open source high fidelity robot simulator improved upon met needs vrc competition additionally cloudsim created act interface users cloud hosted simulations result work achieved automated deployment cloud resources robotic simulations near real time simulation performance simulation accuracy closely mimics real hardware tools released open source licenses freely available used help reduce robot algorithm design development time increase robot software robustness
globally convergent fully coupled inverse model smart materials presented practice stress field electric magnetic temperature applied smart materials whereas strain flux density electric magnetic temperature measured refer constitutive models follow scheme direct models certain design control situations however inverse models necessary field stress found specified flux density strain inversion typically involves iterative procedure may prone convergence issues inverse model approach proposed arbitrary smart materials inversion requirement continuous second order differentiable direct model chosen smart material approach globally convergent makes ideal use finite element frameworks premise proposed iterative system model constitute recursive correction formula based second order approximations novel scalar error function offers faster convergence rate continuation approach used achieve global convergence arbitrary input parameters magnetostrictive galfenol chosen illustrate effectiveness inverse model compact analytical derivations jacobian hessian matrices presented convergence rate proposed approach superior existing inverse model finally inverse model robustness demonstrated integration model finite element framework simulate magnetostrictive composite plate actuator full elsevier rights reserved
didactical methods changing construction education contemporary times advent information technology building information modelling bim modern tools unmanned aerial vehicles laser scanners influencing construction education critical universities introduce new tools construction management education bim promising tool purpose currently several universities worldwide offer bim courses programs many others process integrating bim curricula matter fact universities lack realization importance bim application bim teaching strategy plans overcome barriers integration bim curriculum study analyzed current state bim education program universities pakistan developed countries offering architectural engineering construction education detailed literature review questionnaire survey performed purpose research presented status bim education pakistani universities formulated framework provide guidelines universities currently implementing bim started developing bim curriculum result universities able produce graduates equipped necessary knowledge skills modern tools bim enter professional career published elsevier ltd
paper explains reason difference maximum torque speed characteristics power factor motor generator modes investigates influence machine design parameters difference stator resistance rotor resistance iron loss etc analytical mathematical model based reference frame employed investigation shown difference torque speed characteristics motor generator modes mainly caused opposite direction axis current affected stator resistance value finally analytically calculated torque speed characteristics motor generator modes verified finite element analyses
computer programming technological part creative part involves specific technical aspects programming languages creative aspects find best solutions different problem domains programming learning process encompasses group different teacher student techniques put practice techniques object learning programming language solve real problems learning process must include good software development practices analysis design novice programmer disciplines developing quality software improve learning programming process use techniques methods software development adapting context courses programs curricula different methods help develop quality software article case study using psp personal software process method extreme programming techniques curricula first programming course engineering students support learning process programming language acquiring good software development habits wiley periodicals inc
study presents fabrication characterization novel bactericidal nanoceria doped composite nanofibers nanoceria doped composite nanofibers fabricated physically blending polyurethane two biopolymers cellulose acetate zein nanoceria prepared electrospinning sol gel composed cerium nitrate hexahydrate polyvinylpyrrolidone followed calcination sonication physicochemical characterizations synthesized nanoceria doped composite nanofibers carried ray diffraction pattern field emission scanning electron microscopy transmission electron microscopy antibacterial activity tested common pathogenic bacteria escherichia colt klebsiella pneumoniae salmonella enterica gram negative staphylococcus aureus enterococcus faecalis gram positive nanoceria doped composite nanofibers demonstrated effective toxicity gram positive gram negative bacterial strains obtained results indicate inhibition dependent concentration nanoceria doped composite nanofibers tem analysis reveals nanoceria caused disruption cell membranes led irreversible damage cell envelope eventually leading cell death generally nanoceria doped composite nanofibers depicted promising nanomaterial exceptional antibacterial treatment used another smart material biomedical industrial applications elsevier ltd techna group rights reserved
present study assessed negative emotions associated traumas infertility child rearing child disability death correlates duration trauma widely used chinese mental health scale used assess negative emotions individuals experienced aforementioned traumas control group results showed individuals infertility exhibited greater anxiety depression solitude controlgroup bereaved parents greater solitude fear control group parents children disabilities greater solitude control group parents experienced death child fear physiological maladjustment parents child disabilities addition individuals without parenting experience higher scores solitude fear physiological disease parenting experience controlling demographic variables duration trauma significantly negatively predicted depression infertile group bereaved parents results suggest order prevent psychological physiological health problems among infertile couples parents disabled child parents experience death child family community based strategies developed implemented elsevier inc rights reserved
present method parallel block sparse matrix matrix multiplication distributed memory clusters using quadtree matrix representation data locality exploited without prior information matrix sparsity pattern distributed quadtree matrix representation straightforward implement due recent development chunks tasks programming model parallel comput quadtree representation combined chunks tasks model leads favorable weak strong scaling communication cost number processes shown theoretically numerical experiments matrices represented sparse quadtrees chunk objects leaves hierarchy block sparse submatrices sparsity dynamically detected matrix library may occur level hierarchy within submatrix leaves case graphics processing units gpus available cpus gpus used leaf level multiplication work thus making use full computing capacity node performance evaluated matrices different sparsity structures including examples electronic structure calculations compared methods exploit data locality locality aware approach reduces communication significantly achieving essentially constant communication per node weak scaling tests elsevier rights reserved
object class segmentation computer vision task requires labeling pixel image class object belongs deep convolutional neural networks dnn able learn take advantage local spatial correlations required task however restricted small fixed sized filters limits ability learn long range dependencies recurrent neural networks rnn hand suffer restriction iterative interpretation allows model long range dependencies propagating activity property especially useful labeling video sequences spatial temporal long range dependencies occur work novel rnn architecture object class segmentation presented investigate several ways train network evaluate models challenging nyu depth dataset object class segmentation obtain competitive results elsevier ltd rights reserved
objectives early feasibility clinical test mitral loop cerclage annuloplasty treat secondary mitral valve regurgitation background secondary mitral regurgitation characterized cardiomyopathy mitral annular enlargement leaflet traction contributing malcoaptation transcatheter mitral loop cerclage applies circumferential compression mitral annulus creating loop coronary sinus across interventricular septum protecting entrapped coronary arteries compression interactive annular reduction echocardiographic guidance first human test mitral loop annuloplasty methods five subjects severe symptomatic secondary mitral regurgitation underwent mitral loop cerclage echocardiographic computed tomography follow months results mitral loop cerclage successful subjects aborted unsuitable septal coronary vein anatomy immediately months measures mitral valve regurgitation effective orifice area regurgitation fraction chamber dimensions left atrial left ventricular volumes reduced progressively ejection fractions increased two persistent permanent atrial fibrillation spontaneously reverted sinus rhythm follow one subject experienced small myocardial infarction unrecognized small branch coronary occlusion another experiencing cardiogenic shock baseline died intractable heart failure weeks conclusions first human test mitral loop cerclage annuloplasty successful attempts caused reverse remodeling reduction secondary mitral regurgitation heart chamber volumes suggested electrical remodeling reversion atrial fibrillation evaluation warranted american college cardiology foundation published elsevier rights reserved
background nurses may unwilling accept hiv infected colleagues continue towork patients provider patient transmission risks appropriately assessed aims assess factors associated nurses willingness accept hiv infected colleagues coworkers design descriptive cross sectional methods anonymous online survey targeting japanese nurses working hospitals clinics logistic regression analysis used evaluate factors associated willingness accept hiv positive colleagues risk assessment results respondents avoided contact expressed discriminatory views hiv infected colleagues less willing accept undertaking appropriate risk assessment high level knowledge regarding hiv transmission increased likelihood acceptance towards hiv infected colleagues conclusions use risk assessment may increase nurses willingness accept hiv infected colleagues particularly among workers high level knowledge hiv
investigate effect providing information benefits children attending formal child care women intend use formal child care work postulate reaction information differs across women according characteristics specifically level education present randomized experiment italian women reproductive age children exposed positive information formal child care text message video others find positive effect intention use formal child care negative effect intention work average result hides important heterogeneities positive effect formal child care use driven high educated women negative effect work intention found among less educated women findings may explained women education reflecting work family orientation ability afford formal child care
smart material based actuators smart actuators known prominent characteristics high resolution positioning high bandwidth ease integration miniaturized systems however applications restricted inherent hysteresis nonlinearity paper presents new modified bouc wen mbw model rate dependent property proposed model directly used developing robust adaptive control order eliminate hysteresis effects finally efficacy designed control framework verified via real case giant magnetostrictive actuator gma used testbed
development public transit systems accessible safe everyone including people special needs objective justified civic economic points view unfortunately public transit services conceived people reduced physical cognitive abilities paper present intelligent public transit system highway goal facilitating access improving safety public transit persons special needs system deployed using components commonly available transport infrastructure sensors mobile communications systems positioning systems addition system operate non urban transport contexts isolated rural areas availability basic infrastructure electricity communications infrastructures always guaranteed construct system principles techniques ubiquitous computing ambient intelligence employed illustrate utility system two cases services rendered system described first case involves surveillance system guarantee accessibility bus stops second case involves route assistant blind people
canada generation national program established coordinate research development support development supercritical water cooled reactor scwr concept provide safe economical clean power canadians future undergone phases involving federal laboratories federal agencies academia majority work phase focused establishing infrastructure collaborating partners performing fundamental whereas phase focused applied support completing canadian scwr concept given fundamental long term nature generation research canadian universities actively engaged addressing challenges nuclear reactor system canadian nuclear laboratories formerly atomic energy canada limited played integral role achieving goals generation national program leading scwr concept design effectively partnering national laboratories natural resources canada national research council canada fostering innovative network development highly qualified people overall many test facilities constructed enhancing capabilities partners many technical papers published international conferences journals large number highly qualified personnel trained nuclear non nuclear industries paper highlights unique collaborative structure key contributions canadian program generation international forum community
paper novel model reference adaptive control mrac based hybrid control algorithm presented trajectory tracking tri rotor unmanned aerial vehicle uav mathematical model tri rotor based newton euler formula whereas mrac based hybrid controller consists fuzzy proportional integral derivative pid fuzzy proportional derivative controllers mrac used main controller dynamics parameters adaptive controller fine tuned controller altitude control subsystem pid controller attitude control subsystem uav stability system ensured proven lyapunov stability analysis proposed control algorithm tested verified using computer simulations trajectory tracking desired path input effectiveness proposed algorithm compared pid fuzzy logic controller flc proposed controller exhibits much less steady state error quick error convergence presence disturbance noise model uncertainties
paper frequency domain modeling methodology applied various multi rotor aerial vehicles introduced primary contribution work systematic integration first principles modeling system identification approaches generate flight dynamics models good accuracy first principles modeling model linearization conducted obtain appropriate baseline model subsequent system identification next four step parameter identification process consists baseline model determination data collection preprocessing mode wise parameter identification model fidelity validation performed frequency domain identify uncertain parameters method applied two custom built multi rotor aircraft one type quadcopter one qud quadcopter efficiency demonstration
photoageing represents addition extrinsic chronic ultraviolet radiation induced damage intrinsic ageing accounts age associated changes skin appearance study evaluated effect bpf highly concentrated extract bergamot fruit citrus bergamia uvb induced photoageing examining inflammatory cytokine expression telomere length telomerase alterations cellular viability human immortalized hacat keratinocytes results suggest bpf protects hacat cells uvb induced oxidative stress markers photoageing dose dependent manner could useful supplement skin care products together antioxidant properties bpf highly concentrated extract bergamot fruit appears modulate basic cellular signal transduction pathways leading anti proliferative anti aging immune modulating responses
discrete cosine transform dct based jpeg standard significantly improves coding efficiency image compression unacceptable event serious blocking artifacts low bit rate low efficiency high definition image light phase digital filtering theory paper proposes novel transform based discrete sine transform dst called phase discrete sine biorthogonal transform apdsbt applying apdsbt jpeg scheme blocking artifacts reduced significantly reconstructed image apdsbt jpeg better dct jpeg terms objective quality subjective effect improving efficiency jpeg coding structure jpeg analyzed analyze key factors design evaluation jpeg compression massive parallel graphics processing units gpus using compute unified device architecture cuda programming model experimental results show maximum speedup ratio parallel algorithm apdsbt jpeg reach times low version gpu new parallel strategies illustrated paper improving performance parallel algorithm optimal strategy efficiency improved
authors propose method normalizing analyzing structures enables automated cross comparison features observed tested structures predefined structures anti patterns additionally language enabling symbolic representation structural knowledge presented used demonstration proposed method applied mechanical shafts used qualitative purposes complex calculation models
objective describe reliability validity new measure soda skills questionnaire traumatic brain injury ssq tbi methods fifty one adults severe tbi completed ssq tbi questionnaire scores compared informant self report questionnaires addressing frontal lobe mediated behaviour well performance objective measure social cognition neuropsychological tasks order provide evidence concurrent divergent predictive validity results internal consistency excellent alpha convergent validity good informant ratings ssq tbi significantly correlated neuropsychiatric inventory disinhibition sub scales current behaviour scale frontal systems behaviour scale however relationship seen objective measure social skills neuropsychological tasks disinhibition significant relationship real world psychosocial outcomes sydney psythosocid reintegration scale conclusions study provides preliminary findings good internal consistency convergent predictive validity social skills questionnaire adapted appropriate individuals tbi assessment psychometric properties test test reliability factor structure warranted
background college students high incidence unplanned pregnancies china highly raised public attention numerous reproductive health services provided college students study examined whether health services college lead contraceptive use among female college students heterosexual relationships methods self administered questionnaire survey cross sectional design administered among female students four colleges wuhan china identify health service factors associated contraceptive use past months results analysis revealed younger female students lower odds contraception use whereas students reported availability health related web sites likely use contraceptives female students reported contraceptives birth control counselling accessible college health services greater odds contraceptive usage finally provision contraceptives birth control counselling school associated greater odds contraceptive use conclusions contraceptive related health services play important role reducing unintended pregnancies directly addressing contraceptive needs female students programs provide targeted services may help reduce high rates unexpected pregnancies among female students china
backgroundthe eye complex structure derived neural tube surface ectoderm migratory mesenchyme neural crest origin structures evolve neural tube may affected folate folic acid deficiency aim work investigate whether maternal folic acid deficient diet may cause developmental alterations mouse eye methodsfemale cbl mice weeks old assigned two different folic acid groups periods ranging weeks animals killed gestation day hepatic folate analyzed eyes fetuses macroscopically studied sectioned immunolabeled anti transforming growth factor tgf anti tgf rii resultsmice exposed deficient diet exhibited numerous eye macroscopic anomalies anophthalmia microphthalmia microscopically eye affected organ fetuses highest incidence malformations occurred week onward statistically significant linear association number maternal weeks deficient diet embryonic microscopic eye malformations observed optic cup derivatives structures forming eye anterior segment showed severe abnormalities addition tgf tgf rii expression eye also altered conclusionthis study suggests adequate folic acid folate status plays key role formation ocular tissues structures whereas vitamin deficiency negatively associated normal eye development even short term exposure wiley periodicals inc
introduction gastrooesophageal reflux disease gerd possible cause chronic cough laparoscopic fundoplication well established treatment gerd retrospective study effectivity operation gerd associated cough examined possible preoperative predictive factors concerning post surgical therapy effect characterized patients methods patients laparoscopic fundoplication due gerd treated proton pump inhibitors without associated cough evaluated three month follow data analysis regarding indication point score typical symptoms well findings gastroscopy histology hour oesophagus metry results leading symptoms heartburn regurgitation complete freedom complaints reached patients postal surgically group patients free cough months significant improvement unchanged irritant cough higher values typical reflux symptoms therapy resistance proton pump inhibitors ppi clearly seen patients patients showed less reflux complaints lower ppi resistance frequent allergies well significantly often acid bitter taste hoarseness subdivision patients subgroups mainly reflux mainly cough lowest values heartburn regurgitation ppi resistance found subgroup diagnostics show significiant differences groups although trend could seen towards fewer duodenogastric bile reflux larger hiatus hernias higher demeester scores also smokers non allergic asthmatics polyallergic sufferers cough profited intervention conclusion patients reflux associated respiratory symptoms present entity good ppi therapy response heartburn cough considered often surgery since cough symptoms two thirds appropriately selected patients disappear short time surgery laparoscopic antireflux surgery also considered pneumological aspects individual predictors success antireflux surgery sum relevant individual case history clinical criteria combined used score provide reliable indication surgery
new scanning system named vertex picker developed rapid collect alpha decay events calibration sources range energy relation nuclear emulsion computer controlled optical microscope scans emulsion layers exhaustively high speed high resolution camera takes micrographs dedicated image processing picks vertex like shapes practical operations alpha decay search demonstrated emulsion sheets icek experiment alpha decays nearly events detected eye check work monitor per hour yield nearly times effective conventional eye scan method speed quality acceptable coming new experiment parc
brain inspired circuits provide alternative solution implement computing architectures taking advantage fault tolerance generalization ability logic gates brief advance memristive threshold circuit configuration consisting memristive averaging circuit combination operational amplifier cmos inverters application realizing complex computing circuits developed memristive threshold logic gates used designing fast fourier transform multiplication circuits useful modern microprocessors overall proposed threshold logic outperforms previous memristive cmos logic cells every aspect however indicate lower chip area lower total harmonic distortion controllable leakage power higher power dissipation respect cmos logic
one gold standards animal models rheumatoid arthritis murine collagen induced arthritis model native type collagen together cfa injected susceptible mouse strains unfortunately mice mhc haplotypes susceptible making widely used cbl mouse strain carries haplotype resistant disease issue european journal immunology stevanin etal eur immunol convincingly show although cbl mice resistant collagen induced arthritis mice homozygous deletion cdb genetic background fully susceptible important animal model rheumatoid arthritis clearly demonstrate injection type collagen together cfa leads early onset disease high incidence sustained severity authors characterize disease increase leukocyte infiltration enhanced differentiation
study novel approach via improved genetic algorithm iga based fuzzy observer proposed realise exponential optimal infinity synchronisation secure communication multiple time delay chaotic mtdc systems first original message inserted mtdc system neural network model employed approximate mtdc system next linear differential inclusion ldi state space representation established dynamics model based ldi state space representation study proposes delay dependent exponential stability criterion derived terms lyapunov direct method thus ensuring trajectories slave system approach master system subsequently stability condition criterion reformulated linear matrix inequality lmi due random global optimisation search capabilities lower upper bounds search space set seek better fuzzy observer feedback gains accelerating feedback gain based synchronisation via lmi based approach iga exhibits better performance traditional used synthesise fuzzy observer realise exponential synchronisation also achieve optimal infinity performance minimizing disturbance attenuation level recovering transmitted message finally numerical example simulations given order demonstrate effectiveness approach
background latino youth particularly rural settings experience significant disparities rates teen pregnancy violence data available regarding social structural influences latino youth developmental trajectories specifically factors promote wellbeing protect engagement high risk sexual violence related behaviors methods forty two youth aged years old recruited middle schools youth leadership programs participate one eight community based focus groups salinas predominantly latino urban center california rural central coast focus groups covered youths experiences risk protective factors associated exposure violence romantic relationships four researchers completed coding grounded theory approach informed theoretical frameworks social ecological model social capital study design participant recruitment informed community advisory board local youth serving organizations health care providers results participants described family lives rich bonding social capital strong ties parents near peer family members reported parents strong desire promote healthful behaviors social mobility often lacked bridging linking social capital required help youth navigate structural systems college applications access confidential health care youth also reported families link children negative social capital exposure gang affiliation conclusion adolescents agricultural community identified robust sources bonding social capital within families however identified limitations families capacities link structural resources education employment health care could support healthful behaviors upward social mobility
aimsto assess pharmacokinetics safety proposed etanercept biosimilar two studies comparison etanercept originator etn bioequivalence study comparison administered via autoinjector prefilled syringes pfs delivery study methodsboth studies randomized two sequence two period crossover studies conducted healthy male subjects bioequivalence study subjects randomized receive single mgsubcutaneous injection etn delivery study subjects randomized receive single mgs injection via pfs following wash period days subjects bioequivalence study received single mgs injection etn subjects delivery study received single mgs injection via pfs resultsthe geometric mean ratios confidence interval etn max auc tlast auc inf within predefined bioequivalence range geometric mean ratios confidence interval pfs max auc tlast auc inf also within range new safety issues reported three subjects low titres non neutralising anti drug antibodies follow visit bioequivalence study conclusionsthe similar etn demonstrating bioequivalence safety profile consistent previous reports etn provided equivalent dosing tolerability pfs
children conduct disorder increased risk developing antisocial personality disorder psychopathy adulthood neuroimaging research identified abnormal cortical volume however comprises two genetically developmentally separable components cortical thickness surface area aim study explore relationship cortical constituents boys applied freesurfer software structural mri data derive measures boys controls relationships cortical measures investigated boys significantly reduced compared non boys ventromedial dorsolateral prefrontal cortex found significant group differences reduced prefrontal boys associated significantly reduced regions finding may help identify specific neurodevelopmental mechanisms underlying cortical deficits observed
switched reluctance motor electric motor possesses advantageous features qualifies used electric vehicle aerospace application various drivers previously actively used drive switched reluctance motor paper switched reluctance motor controlled utilizing vector control using fuzzy logic controller ann controller order minimize torque ripple regulating torque within specified hysteresis band fuzzy logic ann control switched reluctance motor fed asymmetrical converter controllers simulated matlab simulink fixed srm parameters according obtained results switched reluctance motor performing well driven fuzzy logic controller comparison ann controller
study tested whether including objects perceived highly interesting children autism gaze following task would result increased first fixation durations target objects previously found autistic children differentiate less object another person attends unattended objects terms measure less differentiation attended unattended objects asd compared control children found baseline condition high interest condition however typically developing children differentiated less attended unattended objects high interest condition baseline condition possibly reflecting reduced influence gaze cues object processing objects highly interesting
biologic therapy target tumor necrosis factor tnf signaling proven efficacious method treatment patients inflammatory bowel disease ibd regards symptom management mucosal healing however rising prevalence ibd worldwide ever increasing burden biologic pharmaceuticals health care industry alarming insurance companies clinicians patients impending patent expiry relatively high costs biologics particularly anti tnf agents paved way biosimilar development ibd united states food drug administration defines biosimilar biological product highly similar reference medicinal product clinically meaningful differences terms safety purity potency hope biosimilars entry market able drive competition pharmaceutical companies reduce prices like generic market access appropriate biologic treatments ibd patients increased long term yet challenging issues indication extrapolation interchangeability still debated field ibd must addressed future issued guidance review discuss issues implications concerning use biosimilar therapy ibd
exploratory study provides insights everyday realities concerns cultural perspectives latinas undergoing chemotherapy elicits information stress management information needs informed community based participatory research approach using qualitative methods conducted ten interviews providers two focus groups depth interviews latinas recently diagnosed breast cancer providers latina patients acknowledged multiple physical emotional stressors associated cancer treatment viewed positive aspect cancer experience include connection god enhanced spirituality saw family motivating factor recovery expressed need draw existing coping strategies findings show considerable overlap providers latina cancer patients perceptions stressors chemotherapy however notable differences perceptions stress management needs treatment period emerged latina cancer patients mentioned similar social structural stressors economic problems lack information tended emphasize interpersonal stressors related family communication relationships providing caring family distance family intrapersonal stressors fear changes physical appearance side effects chemotherapy study illustrates importance including multiple perspectives information gained including providers patient perspectives yielded complete understanding stress management needs latinas undergoing chemotherapy findings suggest stress management educational interventions aim develop self care skills culturally relevant language specific build upon stress reducing strategies latinas may already employ
emerging technologies often part official industry patent trademark classification systems thus delineating boundaries measure early development stage nontrivial task paper aimed present methodology automatically classify patents concerning service robots introduce synergy traditional technology identification process namely keyword extraction verification expert community machine learning algorithm result novel possibility allocate patents reduces expert bias regarding vested interests lexical query methods avoids problems citation approaches facilitates evolutionary changes based upon small core set worldwide service robotics patent applications derive apt gram frequency vectors train support vector machine relying titles abstracts ipc categorization document altering utilized kernel functions respective parameters reach recall level precision level
goal child health services merely treating even preventing childhood diseases disorders expanded promoting children optimal healthy development pediatrics evolved exclusive focus treatment illness opportunity promote children healthy development evolution profound implications content child health services programs system transformation public policy enhanced understanding impact social determinants children health developmental outcomes underscores importance evolving framework system transformation key policy implications
video demand vod popular application internet past years vod services shifted cloud although transformation introduces many benefits arouses new challenges data security due outsourcing storage untrusted cloud servers satisfying requirements fine grained access control cloud attribute based encryption abe algorithms applied field however due large number videos users cloud exist frequent subscribing unsubscribing behaviors numerous categories induce challenges higher flexibility efficiency existing schemes discuss challenges sufficiently paper propose abe based secure independent update concise expression access control sicac scheme cloud provide flexible efficient authentication authorization vod services aspect access policy update guarantee users affect design independent update key policy abe abe algorithm allows users update keys separately existing schemes require members group updated simultaneously aspect attribute description reduce storage cost propose concise expression access structure describe various logic relationships flexibly efficiently security proved standard model experiment implemented pairing based cryptography pbc library theoretical analysis experimental results show scheme efficient effective vod services cloud elsevier inc rights reserved
astrocytes apolipoprotein apoe play critical roles cognitive function physiological conditions also pathological situations particularly pathological progression alzheimer disease regulatory mechanisms underlying effect apoe derived astrocytes cognitive deficits pathology development unclear study generated amyloid precursor protein apoe knockout app apoe app glial fibrillary acidic protein gfap apoe mice mice model used study based app familial alzheimer disease overexpression investigate role apoe derived astrocytes pathology cognitive function explore mechanism investigated amyloidogenic process related transforming growth factor beta mothers decapentaplegic homolog signal transducer activator transcription tgf beta smad stat signaling pathway confirmed administering tgf beta overexpression adeno associated virus specific astrocytes app gfap apoeko mice tgf beta inhibition adeno associated virus specific astrocytes app mice whole body deletion apoe significantly ameliorated spatial learning memory impairment reduced amyloid beta protein production inhibited astrogliosis app apoe mice well specific deletion apoe astrocytes app gfap apoe mice moreover amyloid beta protein accumulation increased due promotion amyloidogenesis app astrogliosis upregulated activation tgf beta smad stat signaling furthermore overexpression tgf beta astrocytes app gfap apoe mice abrogated effects apoe knockout contrast repression tgf beta astrocytes app mice exerted therapeutic effect similar apoe knockout data suggested apoe derived astrocytes contributes risk tgf beta smad stat signaling activation findings enhance understanding role apoe derived astrocytes suggest potential biomarker therapeutic target elsevier inc rights reserved
paper binary bell polynomials employed find bilinear form bilinear backlund transformation lax pair dimensional bkp equation based hirota bilinear form three wave method multi soliton solutions presented furthermore new bilinear backlund transformation constructed via applying gauge transformation backlund transformation bilinear form
paper advanced control strategy validated liquid vessel heat exchanger applications principal characteristics strategy predictive functional control presented due simplicity implementation tuning algorithm adopted large wide systems compared pid controller performances approach improved simulation results even perturbations constraints addition qualitative results hydrogen energy publications llc published elsevier ltd rights reserved
purpose investigate details flow structure plug like jet vortex ring pulsatile stenotic phantoms using flow mri method pulsatile newtonian flows two stenotic phantoms reductions area scanned flow mri blood analog working fluid circulated via stenotic phantom using pulsatile pump constant pulsating frequency velocity vorticity fields plug like jet vortex ring quantitatively analyzed spatial temporal domains results pulsatile stenotic flow showed plug like jet specific stenotic degree pulsatile waveform design plug like jet found decelerating period post stenotic region revealed vortex ring structure vorticity strength range conclusion observed plug like jet vortex ring pulsatile stenotic flow vitro visualization using flow mri plug like jet local fastest flow region occurred post systole phase post stenotic region distinguishable typical stenotic jet flow systole phase elsevier inc rights reserved
mismatch removal key step many computer vision problems paper handle mismatch removal problem adopting shape interaction matrix sim given homogeneous coordinates two corresponding point sets first compute sims two point sets detect mismatches picking different entries two sims even strong affine transformations outliers noises burstiness method still work well actually paper first non iterative mismatch removal method achieves affine invariance extensive results synthetic points matching data sets real image matching data sets verify effectiveness efficiency robustness method removing mismatches moreover applied partial duplicate image search method reaches higher retrieval precisions shorter time cost compared state art geometric verification methods
paper presents equivalent circuit model metamaterial absorber based triple hexagonal shaped resonators metamaterial unit cell absorber possesses nearly wide angle perfect absorption incidence wave polarization independence absorption occurred three different frequencies absorptivity high ghz ghz ghz respectively equivalent circuit model single hexagonal ring extended triple band absorber structure simulation circuit model agrees well full wave simulation regarding return loss absorption important features method simple fabrication metamaterial absorber maximum absorption three frequencies proposed metamaterial absorber wide applications thermal detector stealth technology imaging moreover good agreement simulation measurement results observed
worry common phenotype psychiatric patients normal population worry seen covert behavior primary function avoid aversive emotional experiences research group developed treatment protocol based operant model worry use exposure based strategies extinguish catastrophic worry thoughts aim study test treatment delivered via internet large scale randomized controlled trial randomized high worriers pswq either internet based extinction therapy ibet waiting list condition results showed ibet superior overall large group effect size confidence interval pswq ibet group classified responders corresponding figure participants ibet also superior secondary outcome measures anxiety depression meta cognitions cognitive avoidance quality life overall treatment results maintained ibet group month follow results trial encouraging indicate worry targeted accessible novel intervention worry replication trials active control group needed
fixation demanding procedure particularly patients variants anatomy inferior articular process iap axis alternative screw placement report results study iap anatomy present clinical experience patients operated technique anatomical study angiographies vertebral arteries used study therefore iaps considered measured axial sagittal planes length height width facet distance anterior cortex distance screw entry point also measured angle sagittal plane external tangent line clinical report patients treated iap screws spine surgery department university hospital lyon france january january anatomical study mean length iap mean distance anterior cortical layer mean angle found degrees degrees clinical report patients presented post traumatic instability patients presented degenerative disease patient treated pseudoarthrosis tumour opll rheumatoid arthritis screws correctly positioned injury iap screws represent safe alternative option fixation
background many studies shown migraine patients interictal habituation deficit visual evoked potentials veps discordant results attributed non blinded analyses lack repeatability aims study compared blinded non blinded analyses recordings assessed test retest repeatability methods vep recordings healthy volunteers hvs episodic migraine patients ems interictal ictal analysed two investigators one blinded diagnosis headache phase twelve hvs nine ems two recordings test repeatability results blinded non blinded analyses vep habituation normal hvs ems attack deficient ems interictally intra individual habituation percentages highly correlated two recordings separated days conclusions studies showing vep habituation deficit migraineurs attacks unlikely biased non blinding analysis poor repeatability
background multiple sclerosis chronic neurological disease typically diagnosed young adulthood presents wide variety symptoms impairments functional limitations given chronic unpredictable long term nature disease preserving function essential objective purpose study identify psychosocial behavioral factors might influence trajectory functional limitation eleven years longitudinal follow sample persons methods participants completed measures health behaviors related constructs functional limitations annually eleven years longitudinal measures functional limitations analyzed using random effects regression allows study individual differences trajectories measure using best fitting quadratic growth model tested within person effects nutrition interpersonal relationships exercise stress management health responsibilities spiritual growth self rated health barriers controlling age year since diagnosis year dropout functional limitations year results adjusting covariates higher mean scores exercise self rated health related lower levels functional limitations year higher mean scores stress management health responsibilities barriers related higher levels functional limitations year higher mean exercise scores lower mean health responsibilities scores related slower rates progression functional limitations year conclusion findings suggest highly variable trajectory functional limitations may extended shaped health behavior strategies elsevier inc rights reserved
paper explores role international partnerships facilitate low energy building design construction operations briefly discuss multiple collaboration models levels impact support present case study one collaborative partnership model scientific planning support sps team staff lawrence berkeley national laboratory austrian institute technology nanyang technological university formed sps team provide design assistance process support design phase low energy building project specifically sps team worked cleantech two project tenanted laboratory office building seeks green mark platinum highest green building certification singapore sps team hosted design charrettes helped develop design alternatives provided suggestions design process support aggressive energy target paper describes efforts discusses teams like sps team partnership schemes leveraged achieve high performance low energy buildings international scale specifically discusses international institutional partnerships build capacity low energy design challenge status quo building design create new resources support energy savings order elsevier ltd rights reserved
research attempts uncover joint planning problem solving roles developing culture supply chain collaboration scc research views collaborative activities internal external focussed functional areas model validated industry data using pls approach findings show joint problem solving measurement critical developing collaborative culture executing effective planning hence affects core noncore activities collaboration joint planning operation level important culture development research contributes developing collaborative culture making scc effective finally managerial insights future scope highlighted production hosting elsevier ltd behalf indian institute management bangalore
phosphoinositides essential components lipid membranes crucial regulators many cellular functions including signal transduction vesicle trafficking membrane receptor localization activity determination membrane identity functions depend dynamic highly regulated metabolism phosphoinositides require finely balanced activity specific phosphoinositide kinases phosphatases increasing evidence genetic functional studies enzymes often dysregulated mutated autism spectrum disorders particular phosphoinositide kinases regulatory subunits appear affected frequently examples autism spectrum disorders defective phosphoinositide metabolism fragile syndrome autism disorders associated mutations phosphoinositide phosphatase tensin homolog deleted chromosome pten recent genetic analyses also suggest select nonsyndromic idiopathic forms autism may altered activity phosphoinositide kinases phosphatases isoform specific inhibitors phosphoinositide kinases already developed cancer research treatment evaluated use humans altogether offers exciting opportunities explore altered phosphoinositide metabolism therapeutic target individuals certain forms autism review summarizes genetic functional studies identifying defects phosphoinositide metabolism autism related disorders describes published preclinical work targeting phosphoinositide kinases neurological diseases discusses opportunities challenges ahead translate findings animal models human cells clinical application humans wiley periodicals inc
parkinson disease second common neurodegenerative disease humans hormone alpha melanocytestimulating hormone alpha msh reported neuroprotective previous studies aim study investigate neuroprotective effects alpha msh neurotoxicity methyl phenylpyridinium mpp results indicated treatment alpha msh cells attenuated mpp induced oxidative stress embodied exacerbated reactive oxygen species protein carbonyls addition found alpha msh could improve mitochondrial function cells increasing level adeno sine triphosphate mitochondrial membrane potential furthermore treatment alpha msh restored reduction cell viability induction lactate dehydrogenase release induced alpha msh importantly hoechst staining results indicated alpha msh treatment significantly reduces number apoptotic cells treatment mpp mechanically found alpha msh prevented apoptosis signals reducing level cleaved caspase attenuating cytochrome release data imply alpha msh produces protective effect
background sleep important contributor physical mental health however chronic sleep deprivation become common adolescents especially weekdays adolescents aged years recommended sleep per night maximize overall health well although sleep needs may vary individuals sleep duration recommendations important surveillance help inform policies interventions population healthy sleep behaviors long sleepers rare among teenagers sleeping much problem per insufficient sleep associated adverse health outcomes pediatric population causes insufficient sleep numerous chronic sleep deprivation poses serious threat academic success health safety adolescents article focuses link insufficient sleep obesity adolescents discussion call action article argues sleep taken seriously public health community society general given much attention resources nutrition physical activity good night sleep important eating healthy diet regularly physically active overall health sleeping habits also impact eating screen time behaviors therefore influence body weight control summary short sleep duration poor sleep quality late bedtimes associated excess food intake poor diet quality obesity adolescents sleep sedentary behavior physical activity diet interact influence ultimately impact health holistic approach health whole day matters targeting behaviors synergistically needed optimize impact interventions sleep waste time sleep hygiene important factor consider prevention treatment obesity
practical issue present sustaining rehabilitating ecologically vulnerable post mining area environmental condition varies spatially therefore influenced multiple factors paper attempts integrate ecological vulnerability assessment rehabilitation treatment assist land managers revealing vulnerable features along developing treatments vulnerability mitigation using post mining site mountainous area western china study area indicator system framework assessing reducing vulnerability developed based vulnerability analysis geo informatics satellite image processing spatial analysis employed perform assessment planning found higher exposure sensitivity main causes increased vulnerability seriously disturbed post mining area rehabilitation treatments arranged spatially structurally based framework vulnerability mitigation pre evaluation effectiveness shows type rehabilitation convergence effect clusters lowers ecological vulnerability index evi average value evi reduced minimum standards rehabilitation completed altogether integration rehabilitation treatments quantification vulnerability spatially explicit manner critical planners gain insight ecological vulnerability post mining area provides guidance simplify rehabilitation planning respect vulnerability mitigation
report potential catalytic process efficient clean plastic pollution waters great pacific garbage patch gpgp detailed catalytic mechanisms ruo supercritical water gasification common polyolefin plastics including low density polyethylene ldpe high density polyethylene hdpe polypropylene polystyrene investigated batch reactor degrees min four plastics gave high carbon gasification efficiencies cge hydrogen gasification efficiencies hge methane highest gas component yield mol ldpe using ruo catalyst evaluation gas yields cge hge revealed conversion involved thermal degradation steam reforming methanation whereas hydrogenolysis possible additional mechanism conversion aliphatic plastics process benefits producing clean pressurized methane rich fuel gas well cleaning hydrocarbons polluted waters institution chemical engineers published elsevier rights reserved
article windward electricity supplementary actuation desalination control system conducts research wind directly driven desalination high pressure pump complemented electricity network supplementary wind great also may back coupling electrical network system according amount water desalination successively calculated design select vertical axis wind turbine impeller transmission system desalination system control system final assembly test
recent paper proposed system identification method constructing reduced order models electromechanical dynamics large power systems divided multiple coherent clusters using synchrophasors every cluster actual model represented aggregate generator reduced order model aggregate network graph connected one aggregate generator another paper extend identification approach differential algebraic dae models first every cluster associated unique terminal bus referred pilot bus couples internal network rest system proposed algorithm uses synchrophasor measurements pilot buses identify dynamic model aggregate generator cluster using nonlinear least squares retaining identity pilot buses resulting reduced order model form nonlinear electric circuit described aggregate differential algebraic equations illustrate results using two case studies one ieee bus power system another ieee bus power system also discuss reduced order dae models may useful designing shunt controllers pilot buses using synchrophasor feedback
novel topology suitable emulating fractional order capacitors inductors using current excitation achieved using fractional order differentiator integrator block appropriately configured operational transconductance amplifiers scheme capable emulating fractional order capacitors fractional order inductors without modifications structure implementation allows electronic tuning order capacitance inductance bandwidth operation modification bias current post layout simulation results impedance magnitude phase confirm correct emulated behavior fractional order capacitors inductors two examples highlight applications topology realizing fractional order bandpass filter emulating cole impedance model biological applications examples characteristics circuit validated simulation elsevier ltd rights reserved
geoweb laying foundations volunteered geographic information vgi systems led platforms users contribute geographic knowledge open access moreover result advancements visualization virtual globes able visualize geographic data even browsers emerged however integration vgi systems virtual globes fully realized study presented aims visualize volunteered data considering also ease use aspects general public using free open source software foss new application programming interface api nasa web world wind written javascript based web graphics library webgl cross platform cross browser virtual globe created using api accessible webgl supported browser different operating systems devices result requiring installation configuration client side making collected data usable users case world wind java installation configuration java virtual machine jvm required furthermore data collected various vgi platforms might different formats stored traditional relational database nosql database project developed aims visualize query data collected open data kit odk platform cross platform application data stored relational postgresql nosql couchdb databases respectively
current study examined influence parental warmth support verbal hostility adolescents prosocial behavior toward multiple targets stranger friend family using multiple reporters self parent observations data taken times longitudinal project included adolescents parents age child time structural equation models suggested mother warmth associated prosocial behavior toward family father warmth associated prosocial behavior toward friends findings also suggested adolescents prosocial behavior consistently influenced father hostility father warmth finally observational reports father hostility associated adolescent prosocial behavior consistently self child reported parenting discussion focuses importance considering target prosocial behavior differences mothers fathers role self reports compared observations
objective study evaluate predictive values baseline thyroid stimulating hormone rate thyroid stimulating hormone change within euthyroid state development chronic kidney disease conducted longitudinal study korean adults normal thyroid function history thyroid disease incident chronic kidney disease defined estimated glomerular filtration rate min rate thyroid stimulating hormone change determined subtracting baseline thyroid stimulating hormone level thyroid stimulating hormone level measured last visit prior diagnosis chronic kidney disease final visit subjects without chronic kidney disease divided observation period years subjects stratified quintiles according rates thyroid stimulating hormone change person years follow median follow years incident cases chronic kidney disease risk incident chronic kidney disease significantly higher subjects rapid increases quintile decreases quintile thyroid stimulating hormone levels compared reference group quintile fully adjusted models hazard ratios quintiles confidence interval confidence interval respectively however significant association baseline thyroid stimulating hormone risk incident chronic kidney disease development chronic kidney disease associated rate changes thyroid stimulating hormone level rather baseline thyroid stimulating hormone levels
silicon germanium heterojunction bipolar transistor sige hbt models used technology computer aided design tcad investigate single event transients induced heavy ion broadbeam pulsed laser two photon absorption sources comparison transient waveforms provided proper extraction heavy ion broadbeam transients discussed along circuit implications basic laser strike profiles implemented tcad provide insight future design practices simulation software used describe laser induced upsets terms effective linear energy transfer let
liposomes natural vesicles generally based phosphatidylcholine optimization lipid bilayer composition addition little percentages natural lipids still early stage due difficulties experienced classical liposome formation processes mainly reproducibility encapsulation efficiency supercritical assisted liposome formation superlip demonstrated limitations overcome therefore work process tested produce liposomes controlled nanometric diameter effect water solution flow rate drug encapsulation efficiency investigated addition cholesterol chol phosphatidylethanolamine also studied gain control release rate drug entrapped liposomes theophylline selected model hydrophilic drug using superlip process chol liposomes successfully produced nanometric mean diameters optimization lipid composition superlip operative parameters allowed obtain theophylline encapsulation efficiencies drug release kinetics affected liposome composition particular addiction chol allowed slow theophylline release rate results confirmed possibility producing liposomes complex architecture lipid membrane using superlip process elsevier ltd rights reserved
scheme multi functional photonic assisted temporal signal processor proposed using tunable modulation module inside time spectrum convolution system first second order differentiation intensity integration experimentally demonstrated differential integral signals two input signals successfully obtained adjusting band pass optical filter polarization controller
background many plant pathogen secretory proteins known elicitors pathogenic factors play important role host pathogen interaction process bioinformatics approaches make possible large scale prediction analysis secretory proteins puccinia helianthi transcriptome internet based software signalp targetp big predictor tmhmm protcomp utilized predict signal peptides signal peptide dependent secreted proteins among orfs helianthi transcriptome results orfs accounting total proteins identified putative secretory proteins containing signal peptides length majority proteins ranged amino acids signal peptides long signal peptidase spi cleavage sites found putative secretory signal peptides proteins contained lipoprotein signal peptide recognition site signal peptidase spii secretory proteins functions related signal recognition transduction metabolism transport catabolism additionally putative secretory proteins categorized functional groups based gene ontology terms including groups biological process seven cellular component six molecular function gene ontology analysis secretory proteins revealed enrichment hydrolase activity pathway associations established secretory proteins number cell wall degrading enzymes three homologous proteins specific phytophthora sojae effectors also identified may involved pathogenicity sunflower rust pathogen conclusions investigation proposes new approach identifying elicitors pathogenic factors eventual identification characterization extracellularly secreted proteins advance understanding molecular mechanisms interactions sunflower rust pathogen enhance ability intervene disease states
energy consumption computer systems become important economic environmental issue many researchers focused energy consumption hardware software software energy consumption widely adopted green computation practical experimentation research laboratories current researchers fail build consistent concept base software energy consumption critical applications branch coverage concolic testing critical practices validate safety critical systems little effort given measure energy consumption computation energy consumption techniques important issue green green software engineering contribution paper automate computation analysis energy consumption testing technique enhancing branch coverage using concolic testing implement proposed automation framework tool named green analysis branch coverage enhancement empirical study forty java programs evaluation results show developed tool achieves average increase branch coverage average energy consumption automated tool approximately compute branch coverage forty experimental programs
design high speed analog digital converters high frequency active filters analog signal processing systems high demands heir constituent units parameters requires operational amplifiers high gain high unity gain frequency developing operational amplifiers unity gain frequency several gigahertz phase margin cmos process several problems arise main problem mos transistors using reducing high frequencies gain well large phase shifts caused high gate capacitance application bipolar transistors allows obtaining larger high frequency gain much smaller consumption currents article fully differential amplifier bicmos process proposed provides capacitive load unity gain frequency chz gain temperature range degrees current consumption
clinical practice guide analysis made diagnosis treatment adult patients constipation abdominal discomfort spectrum irritable bowel syndrome functional constipation important personal health social impact affecting quality life patients irritable bowel syndrome predominance constipation predominant change bowel movements recurrent abdominal pain bloating frequent abdominal distension constipation characterised infrequent difficulty bowel movements associated excessive straining bowel movement sensation incomplete evacuation often underling cause intestinal functional disorder considered many clinical pathophysiological similarities similar response constipation common drugs fundamental difference presence absence pain way evaluable way nothing severity depends intensity bowel symptoms factors combination gastrointestinal extra intestinal symptoms level involvement forms perception behaviour rome criteria diagnose functional bowel disorders guide adapted rome criteria may first part analysis made alarm criteria diagnostic tests criteria referral primary care digestive disease specialists second part review made therapeutic alternatives available exercise diet drug therapies neurostimulation sacral roots surgery making practical recommendations one published elsevier espana
background global assessment allows patients assess improvement multiple irritable bowel syndrome ibs symptoms however deemed important assess clinically meaningful improvements focusing patient chief complaint severity major ibs symptoms addition global assessment show ramosetron effective individual ibs symptoms pilot study explore clinical endpoints focusing chief complaint patients ibs diarrhea ibs methods database used previously reported post marketing phase randomized placebo controlled pilot trial male patients ibs hypothesis completely different study patients ibs diagnosed according rome iii criteria given either ramosetron placebo daily weeks one week baseline period explore examine endpoints allow evaluation clinically meaningful improvements focusing patient chief complaint chief complaint relief study drug assessed exploratory study results rates patients abdominal pain discomfort stool form stool frequency patients chief complaint administration respectively ramosetron group placebo group responder rates improvement symptoms chief complaint patients administration ramosetron group placebo group last point greatest symptomatic improvement chief complaint ramosetron group compared placebo group shown respect stool consistency bristol stool form scale bsfs scores significantly lower ramosetron group placebo group last point throughout treatment period except week conclusions ramosetron acted effectively stool consistency improvement stool consistency considered clinically meaningful endpoint showing ramosetron effective individual ibs symptoms clinicaltrials gov nct registered june
recently ever increasing number commerce tools made available able help customers generating purposed recommendations many centralized face problems related efficiency scalability distributed case complexity commerce process implies computation overhead client side often unsuitable mobile devices used customers paper study software distribution recommender systems affects performances depending characteristics commerce population end present distributed testbed architecture commerce recommender systems using multi tiered agent based approach generate effective recommendations without requiring onerous amount computation per single client use testbed study main advantages limitations associated problem distributing computation recommendations copyright john wiley sons ltd
dispersive water wave system explored expansion method many new solutions obtained aid method solutions include hyperbolic function solutions trigonometric function solutions rational function solutions new solutions better help understand physical phenomenon dispersive water wave equation
presented work aimed improving confocal imaging obtain highest possible resolution thick biological samples mouse oocyte therefore developed image processing workflow allows improving lateral axial resolution standard confocal microscope workflow comprises refractive index matching optimization microscope hardware parameters image restoration deconvolution compare two different deconvolution algorithms evaluate necessity denoising establish optimal image restoration procedure validate workflow imaging sub resolution fluorescent beads measuring maximum lateral axial resolution confocal system subsequently apply parameters imaging data restoration fluorescently labelled meiotic spindles mouse oocytes measure resolution increase approximately fold lateral fold axial direction throughout depth demonstrates optimized workflow reach resolution comparable simimaging better depth penetration confocal images beads biological sample authors published elsevier inc
study presents results ongoing research project conducted federal highway administration fhwa developing intelligent approach structural damage detection proposed approach established upon simulation compressed data stored memory chips newly developed self powered wireless sensor innovative data interpretation system integrating finite element method fem probabilistic neural network pnn based bayesian decision theory developed damage detection several features extracted cumulative limited static strain data used damage indicator variables another contribution paper define indicator variables simultaneously take account effect array sensors performance proposed approach first evaluated case simply supported beam three point bending efficiency method tested complicated case bridge gusset plate beam gusset plate structures analyzed models static strain data simulations different damage scenarios used calibrate sensor specific data interpretation algorithm viability repeatability method demonstrated conducting number simulations furthermore general scheme presented finding optimal number data acquisition points sensors structure associated optimal locations uncertainty analysis performed contamination damage indicator features different gaussian noise levels elsevier rights reserved
research linking religion prejudice suggests highly religious individuals religious fundamentalists specifically may especially susceptible expressing prejudice toward dissimilar others whereas people less religious fundamentalist show effect selective prejudice hypothesis predicts pattern results occurs cognitive motivational styles particular values associated fundamentalism exacerbate prejudice studies using data sets test selective prejudice hypothesis religious values conflict hypothesis predicts people high low levels fundamentalism prejudiced toward dissimilar beliefs protect validity vitality people belief systems consistent religious values conflict hypothesis found people high low fundamentalism prejudiced toward dissimilar others study differences primarily due differences content religious belief rather style belief study study expanded findings additional measures prejudice found multiple measures threat potential mediators explored possibility integrative perspective total results suggest people relatively high low levels fundamentalism susceptible prejudice cases size religious intergroup bias may higher among people high levels fundamentalism
compatibilism view determinism compatible acting freely morally responsible incompatibilism opposite view often claimed compatibilism incompatibilism natural part ordinary social cognition often claimed patterns everyday social judgments reveal implicit commitment either compatibilism incompatibilism paper reports five experiments designed identify patterns results support nuanced hybrid account central tendencies ordinary social cognition compatibilism moral responsibility compatibilism positive moral accountability deserving credit good outcomes neither compatibilism incompatibilism negative moral accountability deserving blame bad outcomes compatibilism choice actions positive outcomes incompatibilism choice actions negative neutral outcomes
project delivery method great impact project performance construction quality numerous studies project performance two project delivery methods design bid build dbb design build found differing results depending project locations project types project sizes since previous studies conducted regard large sized apartment housing projects paper presents comparative analysis results project performance dbb methods focusing large sized public apartment housing projects built korea project performances considered include cost cost growth construction duration construction duration growth quality performance cost schedule performance analysis results show cost growth method lower dbb method construction duration shortened twelve days per floor quality performance analysis results demonstrate satisfaction method higher terms construction quality efficiency method paper contributes growing body research efficiency project delivery methods expanding body knowledge large sized public apartment housing projects
mini wind generator efficient way save electricity develop potential green wind energy city environment material structure design supporting frame key factor ensure generator work fluently safely manufacturing engineering research dynamic properties frame different structure materials analyzed finite element method epoxy frame fewest number natural frequencies coinciding generator working revolution frequency mode shapes epoxy frame different orders achieved fem new kind analytical method key node component displacement criterion proposed respect displacement characteristic frame different mode orders criterion provides new approach evaluating deformation characteristic dynamic properties mechanical structures
work focuses development multiscale computational fluid dynamics cfd simulation framework application plasma enhanced chemical vapor deposition thin film solar cells macroscopic cfd model proposed capable accurately reproducing plasma chemistry transport phenomena within axisymmetric reactor geometry additionally complex interactions take place surface thin films coupled cfd simulation using novel kinetic monte carlo scheme describes thin film growth leading multiscale cfd model due significant computational challenges imposed multiscale cfd model parallel computation strategy presented allows reduced processing time via discretization gas phase mesh microscopic thin film growth processes finally multiscale cfd model applied pecvd process industrially relevant operating conditions revealing non uniformities greater growth rate amorphous silicon films across radius wafer
although effectiveness clozapine clz patients treatment resistant schizophrenia trs well established active mechanism completely clarified several clinical studies showed neuroleptic induced dopamine supersensitivity psychosis dsp could involved etiology trs preliminarily explored possible beneficial effect clz dopamine supersensitivity schizophrenia present study case series followed patients dsp years introduction clz compared prevalence episodes particularly rebound psychosis tolerance antipsychotic effects tardive dyskinesia period clz treatment observation years following introduction clz showed dsp patients presented dsp episodes one patient showed continued tardive dyskinesia already existed preperiod patient presented rebound psychosis appeared immediately discontinuation clz results present study indicated dsp schizophrenic patients treated general antipsychotics disappeared subsequent years clz treatment suggesting agent ameliorates dopamine supersensitivity state induced previous antipsychotic treatment
session initiation protocol sip selected official end end signalling protocol establishing multimedia sessions based universal mobile telecommunication systems umts network since satellite component identified play integral role umts need also support sip based session establishment satellite umts umts achieve end end seamless based terrestrial satellite network integration however transport sip satellite radio interface efficient due request response nature sip large message size coupled unreliable wireless links larger propagation delay little work carried area paper presents research efficient solutions transport sip session set signalling umts radio interface based radio link control acknowledged mode rlc mechanisms two schemes also proposed overcome inefficiency current rlc procedure applied session set umts proposed enhancements easy implement fully backward compatible existing implementation rlc units elsevier rights reserved
purpose review scavenger receptor classically known role antiatherogenic reverse cholesterol transport selectively takes cholesterol esters hdl highlighted recent literature describes novel functions physiology disease recent findings large population based study revealed patients heterozygous mutant form showed significantly increased levels plasma hdl cholesterol increased risk cardiovascular disease demonstrating humans significant determinant cardiovascular disease furthermore shown modulate susceptibility lps induced tissue injury ability sphingosine phosphate interact receptor linking regulation inflammation addition important domains within molecule trp well novel regulators procollagen endopeptidase enhancer protein selective uptake function recently identified moreover relatively high expression levels protein observed variety cancer tissues associated reduced overall survival rate summary hdl receptor potential therapeutic target cardiovascular disease setting also inflammatory conditions well cancer
paper presents low power bit hybrid incremental sigma delta cyclic analog digital converter adc based pseudo differential operational amplifier designed readout circuit infrared focal plane array detector two stage hybrid adc employs incremental sigma delta adc cyclic adc achieving good trade accuracy conversion speed two stages share analog circuit reduce area power consumption common mood feedback module used suppress influence charge injection effectiveness demonstrated detailed theoretical analysis simulation result test chip fabricated cmos technology hybrid adc column performed parallel power consumption simulation result reveals effective number bits enob bits
aim study investigate whether long term improvement headache patients unruptured intracranial aneurysms uias treated intracranial endovascular procedures using prospective design consecutive patients uias neuroendovascular treatment january december asked participate headache outcomes established aneurysm treatment months following treatment factors associated different headache outcomes investigated ultimately patients completed month follow total patients preoperative headache six months intracranial endovascular procedure patients stated headaches relieved endovascular treatment headache patient improved slightly reported disappearance headache marked improvement overall mean headache scores patients improved self reported numeric rating scale nrs endovascular treatment patients pretreatment tension type headache severe headaches stent assisted coiling stent implantation aneurysm important disadvantage patients improvement post procedure headache treatment uias resulted relief headaches half patients headaches pre operatively
background degrees health disciplines need balance theoretical knowledge sufficient clinical practice meet registration requirements particular requiring specialist skills use scalpels small instruments podiatry however despite requirement scarcity literature research inform teaching particular manual clinical skills therefore aims study determine current approaches used teach manual skills particular scalpel skills university podiatry programs australia new zealand explore issues challenges innovations exist methods qualitative study consisting semi structured interviews staff eight university podiatry programs australia new zealand undertaken determine skills taught evaluated poor performers managed conventional content analysis technique used analyse code interview data resultant categories reported results approaches teaching manual clinical skills particular scalpel skills appear consistent university programs australia new zealand utilising didactic style content demonstration physical practice inanimate objects real skin often use supplementary audio visual material main reported differences programs methods processes practice controversy regarding use inanimate objects versus real skin practice conclusions despite lack research literature surrounding topic approach teaching relatively consistent programs greatest disparity structure duration practice key issues teaching staff teaching manual skills students clinical exposure motivation levels anxiety dexterity
article parallel conjugate gradient squared cgs block centered finite difference scheme introduced analyzed cast numerical solution nonlinear time fractional parabolic equation neumann condition nonlinear reaction term unconditionally stable result depends initial value source item derived priori estimates discrete norm optimal order convergence delta alpha pressure velocity established uniform non uniform rectangular grids delta time step maximal mesh sizes directional grids model simulation iterated series time steps beneficial calculation units time step run separately cgs algorithm adding openmp instructions circulation calculations iterative step realize parallel computing examine efficiency accuracy proposed method numerical experiments using schemes studied results clearly show benefit using proposed approach terms execution time reduction speedup respect sequential running single thread elsevier rights reserved
paper compares hydraulics flow features ordinary rectangular trapezoidal plan view piano key weirs pkws using two phase rans numerical simulations main aim investigate effects inlet key area angle side walls discharge capacity pkw keeping developing length crest intact numerical model used carry sensitivity analysis geometrical parameters hydrodynamics rectangular trapezoidal weirs tpkws compared wide range water head weir results show trapezoidal weir higher efficiency ordinary rectangular pkw partly related inlet key flow conditions trapezoidal geometry increases inlet flow area resulting reduction velocity along key axis consequently flow distributed uniformly side crests gradual transition inlet key limits development recirculation zones along side walls also limits formation critical section along inlet key phenomena result increase effective weir length thus discharge capacity increases trapezoidal weir compared rectangular one discretization discharge along crest tested weirs clearly confirms findings
common end users professional users finds difficult specify queries querying structured databases commonly used applications data management analysis spreadsheet still spreadsheet computation lacks enough analysis combining concepts spreadsheets database system result new formation easily handled end users main topic article offer fully automated method tool constructs spreadsheet implementations relational data transformations paper proposes automated tool store data translate spreadsheet system easily tool called query converter actually converts database queries formula based spreadsheets imposes techniques overcomes limitations database system spreadsheets effective data modeling applications spreadsheets also capable implementing graph traversing algorithms like bfs dfs additional tasks
prospective single arm study participants evaluated extended inr follow interval determine implementation feasibility safety extended interval veterans stable dose warfarin protocol designed allow rigorous yet pragmatic evaluation week inr follow interval feasibility determined study enrollment retention participant achievement rates extended inr interval safety determined bleeding thromboembolism rates participants monitored months despite long term stability participants prior enrollment achieved week follow interval enrolled participants maintained week interval sixteen percent participants never eligible extension inr follow interval despite meeting initial enrollment criteria two major bleeding events one participant experienced thromboembolic event implementation extended interval inr follow appears feasible participant enrollment goals met pharmacists able follow study protocol however lower expected proportion participants able achieve maintain extended inr follow interval future evaluations needed confirm safety extended inr interval
altman score well accepted model predicting survivals failures manufactures since however short underpinning theory causes wide gap asking responding sides still effective solution research proposes rough set approach inducing granular evidence solving evidential coefficients financial ratios distressed companies empirically proposed approach applied financial database taiwan economic journal analyze solar energy industry result shows inferential evidence successfully serves basis financial analysis discloses profit efficiency distressed companies taiwan solar energy industry declining published elsevier
context among collegiate soccer players incidence rate event characteristics hamstrings strains differ sexes comparisons return participation rtp time reported objective compare rtp time male female collegiate soccer players analyze influence event characteristics rtp time sex design descriptive epidemiology study setting data collected collegiate teams voluntarily participated national collegiate athletic association injury surveillance system patients participants collegiate soccer athletes sustained hamstrings strains men women fall seasons main outcome measure nonparametric statistics used evaluate rtp time differences sexes among categories event characteristic time season practice competition player position negative binomial regression used model rtp time sex analyses performed separately first time recurrent strains results found differences rtp time sexes first time median men days women days recurrent median men days women days hamstrings strains male players first time strains rtp time increased strain occurred competition season postseason varied depending division play among female players first time strains found differences rtp time within characteristics male players recurrent hamstrings strains rtp time longer injury occurred season postseason among female players recurrent strains rtp time longer forwards midfielders defenders conclusions although found differences rtp time hamstrings strains male female collegiate soccer players sex unique event characteristics influenced rtp time
mutations scna gene encoding voltage gated sodium channel associated spectrum epilepsies neurodevelopmental disorders report phenotypes patients review previously reported patients found encephalopathies infantile childhood onset epilepsies months age occur almost often early infantile onset months thus frequent previously reported distinct phenotypes seen within late onset group including myoclonic atonic epilepsy two patients lennox gastaut emerging west syndrome two patients focal epilepsies electrical status epilepticus slow sleep like eeg pattern six patients iii west syndrome constitutes common phenotype major recurring mutation arggln two new four previously reported children known phenotypes include ohtahara syndrome epilepsy infancy migrating focal seizures intellectual disability autism without epilepsy assess response antiepileptic therapy retrospectively reviewed treatment regimen course epilepsy patients well documented medical information available find use sodium channel blockers often associated clinically relevant seizure reduction seizure freedom children early infantile epilepsies months whereas antiepileptic drugs less effective contrast sodium channel blockers rarely effective epilepsies later onset months sometimes induced seizure worsening regarding genetic findings truncating mutations exclusively seen patients late onset epilepsies lack response sodium channel blockers functional characterization four selected missense mutations using whole cell patch clamping tsa cells together data literature suggest mutations associated early infantile epilepsy result increased sodium channel activity gain function characterized slowing fast inactivation acceleration recovery increased persistent sodium current good response sodium channel blockers clinically found associated relatively small gain function contrast mutations patients late onset forms insufficient response sodium channel blockers associated loss function effects including depolarizing shift voltage dependent activation hyperpolarizing shift channel availability steady state inactivation clinical experimental data suggest correlation age disease onset response sodium channel blockers functional properties mutations children scna related epilepsy
sporotrichosis disease caused saprophytic dimorphic fungus sporothrix schenckii currently diagnosed worldwide especially tropical subtropical areas infection usually occurs traumatic inoculation soil plants organic matter containing fungus certain activities floriculture agriculture mining wood exploitation zoonotic transmission associated mycosis humans disease limited skin subcutaneous tissue proximal lymphatic occurs commonly lymphocutaneous fixed lesions predominantly affect upper limbs face latter location frequent children however sporotrichosis children uncommonly seen data disease specific group patients scanty gold standard diagnosis culture nevertheless recently added methods serological histopathological molecular useful accurate diagnosis itraconazole first choice treatment sporotrichosis however potassiumiodide also effective option mainly children
noninvasive minimally invasive extracranial stimulation widely investigated treatment primary headache disorders particularly migraine review describe methodological challenges studying occipital supraorbital stimulation devices explore efficacy safety implantable occipital nerve stimulation primary headache disorders including randomized sham controlled clinical trials chronic migraine treatment also review noninvasive supraorbital transcutaneous stimulation preventive therapy episodic migraine
background anesthesiologists work extended hours exhibit acute chronic sleep deprivation newest bilateral bispectral index bis vista monitor offers new advantages earlier models include new algorithm version one possible useful application bis monitoring physiological sleep would critically ill patients almost uniformly suffer sleep disruption deprivation loose circadian rhythm due harsh noisy environment critical care units previous studies used earlier versions bis monitor depict normal physiologic sleep produced widely conflicting results aim study assess whether new bis vista monitor would exhibit temporal decline corresponds natural physiologic sleep stages healthy sleep deprived post call anesthesiologists methods bis vista sensors bilaterally mounted according manufacturer guidelines onto forehead healthy sleep deprived volunteer anesthesiologists using conventional rechtschaffen kales criteria bis values awake rapid eye movement rem sleep stages recorded results meant bis values awake rem sleep stages significantly declined left right hemispheres respectively significant interhemispheric differences bis values time two way anova however one subject left right bis values mostly discordant throughout recordings conclusion demonstrated although bis vista monitor neither designed validated monitoring normal physiologic sleep depicted temporal decline corresponds normal physiologic sleep stages sleep deprived anesthesiologists minerva anestesiol
literature suggests collaborative approaches leadership distributed leadership essential supporting educational innovators leading change teaching universities paper briefly describes array activities processes resources support distributed leadership implementation network science mathematics network australian university educators samnet research study investigated participating educational innovators experiences distributed leadership using mixed method approach years immersion samnet fifty innovators surveyed data analysed obtain influences teams institution samnet focus groups used extract rich descriptions experiences innovators study suggests distributed leadership approach underpinning samnet cultivated leadership helping complement team institutional influences measurable way support educational innovators leading change university science mathematics teaching
soluble starch functionalized graphene oxide composite starch prepared facile esterification reaction composite used novel adsorbent removal aqueous solution chemical composition morphology starch investigated fourier transform infrared spectroscopy scanning electron microscopy raman spectroscopy evaluate effects adsorption starch batch adsorption studies performed optimize major parameters contact time initial concentration temperature maximum uptake capacity optimal conditions furthermore adsorption kinetics isotherms thermodynamics starch also investigated experimental data indicated adsorption kinetics adsorption isotherms starch well fitted pseudo second order kinetic model langmuir isotherm model respectively adsorption thermodynamic parameters calculated delta delta respectively thermodynamic parameters indicated adsorption process endothermic feasible spontaneous due high adsorption capacity starch might considerable potential aqueous removal metal ions soluble starch functionalized graphene oxide composite starch prepared used novel adsorbent aqueous removal chemical composition morphology starch characterized fourier transform infrared ftir spectroscopy scanning electron microscopy sem raman spectroscopy batch adsorption experiments performed optimize major parameters contact time initial concentration temperature maximum uptake capacity optimal conditions adsorption kinetics adsorption isotherms well fitted pseudo second order kinetic model langmuir isotherm model respectively adsorption thermodynamic parameters delta delta indicating adsorption process spontaneous endothermic feasible graphics
detection small target clutter usually regarded singular points infrared image important issue infrared searching tracking irst system far range target sensor stealth technology effects inherent sensor noise phenomena nature target difficult detected multispectral sensor system proved could greatly improve detection small hard find targets multispectral processing techniques sensor image fusion aiming problem multispectral target detection kind method multispectral target detection proposed based existed detection systems method image registration done firstly make different sensors scene fusion rule named adaptive weighted voting theory developed combine target detection results different spectral sensors adaptive weighted voting theory give different weights based different spectral characteristics weights decide detected target identified real target background experimental results show proposed method reduce detection uncertainty improve detection performance compared single spectral detection results others fusion detection methods decrease lost alarm rate false alarm rate effectively proposed method employed surveillance system easy used various circumstances
experimentally investigate effect social identification information feedback individual behavior contests treatments find significant overexpenditure effort relative standard theoretical predictions identifying subjects photo display decreases wasteful effort providing information feedback others effort affect aggregate effort decreases heterogeneity effort significantly affects dynamics individual behavior behavioral model incorporates nonmonetary utility winning relative payoff maximization explains significant overexpenditure effort also suggests decrease social distance group members social identification promotes prosocial behavior decreases overexpenditure effort improved information feedback decreases heterogeneity effort
research deals behavior composite box girder bridges cbgbs subjected environmental effects solar radiation atmospheric temperature wind speed based temperature thermal stress results recorded hourly full scale experimental cbgb segment finite element thermal analysis hemi cube method adopted achieve accuracy temperature distributions variations composition system daily environmental variations analytical findings compared experimental measurements good agreement found hand parametric investigations carried investigate effect cross section geometry orientation longitudinal axis cbgb thermal response stress distributions based upon individual parametric investigations remarks related thermal loading parameters submitted additionally observations cbgb configurations identified must taken account design process finally research indicates design temperature distribution uniform differential concrete slab steel girder inappropriate describing thermal impacts design objective
present sliding mode based control design telescopic link mobile hydraulic forestry crane bounded modeling uncertainties external disturbances mobile hydraulic systems typically subject strong perturbation conditions design resilient control solutions important challenge furthermore nonlinear phenomena primarily characterized easily excited oscillations input nonlinearity friction dominating dynamics proposed control scheme takes advantage input nonlinearity compensation order overcome problems includes formulation sliding mode control based design two strategies chattering attenuation examined aimed improving controller performance experimental results performed industrial setup including comparison pid controller confirm efficacy proposed methodology
need novel approaches understanding treating anorexia nervosa well recognized aim paper describe integrative bio psycho social theory maintaining factors took triangulation approach develop clinically relevant theory face validity internal consistency developed theoretical ideas clinical practice reviewed theoretical ideas within eating disorders wider bio psycho social literature synthesis ideas concepts clinically meaningful framework described suggest eight key factors central understanding maintenance treatment resistance anorexia nervosa genetic experiential predisposing factors dysfunctional feelings processing regulation systems excessive vulnerable feelings feared self beliefs starvation maladaptive physiological feelings regulation mechanism maladaptive psychological coping modes maladaptive social behaviour unmet physical psychological core needs factors serves maintain disorder concept universal physical psychological core needs provide underpinning integrative framework working distinctly physical psychological disorder framework could used within treatment model suggest treatments help address profound lack trust emotional security self acceptance patient group turn address unmet needs improve well copyright john wiley sons ltd
suicide relatively common outcome along course bipolar disorder studies shown positive correlation ideation attempts suicide higher insight schizophrenic patients nevertheless still studies evaluate relationship suicide insight mood disorders evaluate relationship insight suicidal ideation behavior bipolar depression group bipolar patients followed along year patient mood assessed every consultation according dsm criteria suicidal ideation behavior prospectively assessed item ham whenever major depressive episode diagnosed insight evaluated insight scale affective disorders history suicidal attempts associated worse insight patients one episode bipolar depression difference remained even supposed effect depression insight controlled correlation current suicidal ideation insight level found though results suggest history suicide attempts may correlate higher impairment insight bipolar depression relationship found current suicidal ideation insight
large tumours mandible need immediate reconstruction provide continuity mandible satisfactory function jaw well acceptable aesthetic outcome prospective study described immediate reconstruction mandible using computer aided design rapid prototyped patient specific implants psi patients suffering benign malignant tumours demanding continuity resection mandible scaffold psi filled beta tricalcium phosphate granules autologous bone microvascular reconstruction additionally needed cases clinical follow average months radiological follow average months nine cases healing uneventful one patient lost microvascular flap first postoperative week one patient needed revision due perforation mucosa site psi four patients major complication due perforation mucosa leading infection resulted total partial removal psi psi seems promising solution treatment patients demanding large reconstruction mandible resection benefits decreased rate donor site complications accurate prompt surgical procedure published elsevier ltd behalf european association cranio maxillo facial surgery
progranulin pgrn implicated alzheimer disease well frontotemporal lobar degeneration genetic studies demonstrate association common grn variant results reduced pgrn levels increased risk however mechanisms pgrn reduction grn risk variant mutation exacerbates pathophysiology remain ill defined show grn risk variant significant effects florbetapir positron emission tomographic amyloid imaging cerebrospinal fluid csf beta levels whereas associated increased csf tau levels human subjects alzheimer disease neuroimaging initiative studies consistent human data subsequent analyses using appswe app mouse model cerebral amyloidosis show pgrn deficiency exacerbating effects beta pathology contrast unexpectedly pgrn deficiency significantly reduces diffuse beta plaque growth app mice protective effect due least part enhanced microglial beta phagocytosis caused pgrn deficiency induced expression tyrobp network genes tng including risk factor trem pgrn deficient app mice also exhibit less severe axonal dystrophy partially improved behavior phenotypes pgrn deficiency reduces amyloidosis related phenotypes neuronal injury mechanisms increased loss pgrn revealing multidimensional interaction grn example complement deposition synapses enhanced app mice lacking pgrn moreover pgrn deficiency increases tau pathologies human tau expressing mice human rodent data suggest global pgrn reduction induces microglial tng expression increases risk exacerbating neuronal injury tau pathology rather accelerating beta pathology
auto zero chopper operational amplifier supply voltage range realized using cmos process augmented cmos dmos transistors achieves maximum offset voltage drift degrees minimum cmrr noise psd root mhz unity gain bandwidth dissipating current modulated chopper ripple suppressed auto zeroing furthermore glitches charge injection input switches mitigated employing six parallel input stages khz interleaved clocks moves majority glitch energy mhz leaving little energy khz result requirements external low pass glitch filter relaxed wider usable signal bandwidth obtained maximum input bias current due charge injection mismatch reduced post production trimming chip charge mismatch compensation circuit
dna palindromes known many beneficial detrimental functions cell biology functions shared perfect imperfect palindromic sequences imperfect palindromes particular interest due additional ability dramatically increase local mutation rate almost available tools capable extracting genetic palindromes designed accommodate inverted repeats palindromic sequences centralized non matching nucleotides developed computational methods focus specifically perfect imperfect palindromes allowing take advantage palindrome specific properties led increase speed approximately decrease memory requirements compared leading inverted repeats detection method
diagnostic elimination diet sensitization tests dietary history crucial elements diagnosis food allergies goal make sure nutritional needs child remain entire elimination process allergen diet detailed diet history possibly evaluation symptom diary basis creating individual elimination diet strict diets oligo allergenic based diet longer used risk severe dietary deficiencies children pronounced elimination diet needs incorporate food preferences child restrict quality life child family
autism spectrum disorder asd may affect spheres child life indeed parents siblings also live emotional instabilities family experience parents asd child distressing since need make adjustments demanding need cope life situations perhaps life drastically exaggerated complexities life particularly social life radically affected presence pervasive severe deficits children asd isolates parents social life demanding adjustments social environment parents life situations shove distress unstable emotions finally culminate shattered interpersonal relationship family social life indeed aspects distress mask social intelligence parents thus narrow focus treatment rather holistic management child thus management asd parents deficit children reach fullest abilities remains doubtful therefore objectives study follows examine impact emotionality social intelligence parents blessed autistic child develop awareness regarding social intelligence significance among parents propose new model stabilising emotionality parents developing social adaption skills suggest new model guide current intervention regimens ensure emotional well better social adoption study made based keenly examined past evidence correlation emotionality impact social intelligence parents asd children results reveal social intelligence perceived lowered evidenced poor social adjustment reflected social isolation observed parents children asd new model proposed stabilising developing awareness social intelligence among parents asd children integrating model existing treatment paradigm suggested attain better result conclusion drawn study analysing fact considerable improvement diagnosed child may amend parent family distress drastically affect social intelligence indeed intervention promising healthy personality parents multiple aspects intelligence affected new proposed model intervention pave way research regard
agbr agbro nanoparticles loaded porous carbon prepared impregnation method transformed agbr hybrid photocatalytic degradation process ray diffraction pattern transmission electron microscope vis diffuse reflectance spectroscopy applied investigate structures morphologies optical properties prepared samples surface plasmon resonance spr absorption metallic observed vis diffuse reflectance spectroscopy photocatalytic activities evaluated photodegradation rhodamine visible light irradiation elsevier rights reserved
objective order improve understanding hormonal contraceptive failures study evaluates persistence oral contraception use emergency contraception persistence incidents made hypothesis existence strong link risk unplanned pregnancies two parameters study also evaluated women perception order elucidate reasons insufficient use methods one survey carried internet representative sample women aged results survey french women interviewed source population defined target population fertile women heterosexual intercourse last months population women risk unintended pregnancy unprotected sexual intercourse last months risk population little target population meaning source population stopped contraceptive method temporarily average time two months almost women risk unwanted pregnancy period without contraception risk population women among population risk used main reasons given insufficient use misperception risk pregnancy lack knowledge way use conclusion first time survey shows women source population decide stop temporarily contraceptive method average time two months per year fifty nine percent unplanned pregnancy situations due poor contraception persistence although need reduce risk women risk seems also highly desirable overcome consequences poor persistence giving information systematic prescription contraception consultations would lead increased use elsevier masson sas rights reserved
insulin plays crucial physiological role glucose control initiating number signaling events binding activating cell surface receptor insulin mimics therefore become promising agents treating diabetes probe mechanism interaction insulin receptor specifically many insulin mimetic peptide sequences discovered found selectively function agonists antagonists structures mechanistic details interactions receptor remain challenging characterize work studied folding properties structure site insulin mimetic peptide sequence similarities insulin chain well critical hormone binding element receptor known terminal peptide first validated simulation approaches predicting known solution structure insulin chain helix applied study folding mimetic peptide data predict helical fold first residues resemblance helical motifs insulin chain also propose receptor bound models provide mechanistic explanations competing binding properties site wiley periodicals inc
study examined whether increasing proportion false information suggested confederate would influence magnitude socially introduced false memories social contagion paradigm roediger meade bergman psychonomic bulletin review one participant one confederate collaboratively recalled items previously studied household scenes collaboration confederate interjected false items subsequent individual recall tests across three experiments participants likely incorporate misleading suggestions partner mostly accurate incorrect partner accurate incorrect even participants witnessed firsthand partner poor memory related memory task still likely incorporate confederate entirely misleading suggestions subsequent recall recognition tests exp participants witnessed firsthand partner poor memory practice test experimental task able reduce false memory reduction occurred selectively subsequent individual recognition test exp data demonstrate participants always consider partners memory ability working collaborative memory tasks
background fertility treatment guaranteed succeed around patients achieve parenthood failed treatment represents loss parenthood often triggers intense prolonged grief reactions increasing awareness need support patients aftermath failed treatment however effective interventions effect need support expected increase number people delaying parenthood increases therefore number assisted reproduction offer solution objective rationale mixed methods review aims investigating patients failed fertility treatment experience significant psychosocial adjustment difficulties warrant provision psychosocial support developing comprehensive model adjustment unmet parenthood goals used assist design theory led psychosocial interventions search methods five databases systematically searched december search terms variations fertility treatment psychosocial adjustment post treatment quantitative studies include group mean comparisons psychosocial adjustment mental health well patients failed treatment control group qualitative studies focus experiences psychosocial adjustment failed treatment screening data extraction critical appraisal carried independently authors using predefined protocols two meta analyses performed mental health well random effect model primary outcome hedge publication bias checked visual inspection funnel plots egger test trim fill method three stage thematic analysis results reported primary qualitative papers implemented firstorder descriptive second order interpretative themes extracted outcomes nine quantitative individuals countries qualitative individuals countries studies included six quantitative studies reported mental health six well meta analyses showed failed group worse mental health well controls qualitative review resulted first order themes grouped second order themes individual relational adjustment social adjustment acceptance pursuit new life goals meaning making fertility care perceptions needs data showed individual relational social adjustment tended increase time since treatment individuals care perceptions needs also changed data also suggested individuals engage psychological tasks accepting making meaning situation pursuing new life goals adjust better fewer support needs predictions articulated three tasks model adjustment unmet parenthood goals wider implications results provide compelling evidence provision psychosocial care directed helping individuals relinquishing parenthood goals three tasks model adjustment unmet parenthood goals offers comprehensive guidance therapeutic mechanisms psychosocial care target promote adjustment future research test model prospective cohort studies developing testing interventions based predictions
investigation solar like oscillations probing star interiors enjoyed tremendous growth last decade observations notable difficulties properly identifying true oscillation frequencies stars due gaps observation time series intrinsic stellar granulation noise paper presents innovative neuro wavelet reconstructor missing data photometric signals firstly gathered data transformed using wavelet operators filters operation removes granulation noise predict missing data composite two neural networks together allow forward backward reconstruction resulting error greatly lower absolute priori measurement error devised reconstruction approach gives signal better suited fourier transformed compared existing methods elsevier ltd rights reserved
order develop introduce intelligent systems space field adaptive fuzzy logic controller designed nanosatellite attitude determination control subsystem adcs performance efficiency compared traditional proportional integrative derivative pid controller fuzzy controllers already studied satellite attitude control however performance compared classical pid controllers typically implemented board spacecrafts currently controllers designed implemented order tested board nanosatellite qbito nearby mission constellation nanosatellites due requirements imposed mission orbit significant limitations power available small spacecrafts efficient adcs required order fulfill mission objectives comparison classical pid fuzzy controllers shows fuzzy controller much efficient single maneuver less power required achieving better precision general pid shows use type intelligent control systems great advantage conventional control systems currently used satellite attitude control open new possibilities application intelligent controllers field space technologies elsevier ltd rights reserved
planar shape interpolation classic problem computer graphics present novel shape interpolation method blends infinity planar harmonic mappings represented closed form intermediate mappings blending guaranteed locally injective infinity harmonic mappings conformal isometric distortion bounded input mappings key success method fact blended differentials interpolated mapping simple closed form expression evaluated unprecedented efficiency accuracy moreover contrast previous approaches differentials integrable result actual mapping without modification algorithm embarrassingly parallel orders magnitude faster state art methods due simplicity yet still produces mappings superior existing techniques due guaranteed bounds geometric distortion
diseases involving distal lung alveolar epithelium include chronic obstructive pulmonary disease idiopathic pulmonary fibrosis lung adenocarcinoma accurate labeling specific cell types critical determining contribution pathogenesis diseases distal lung alveolar epithelium composed two cell types alveolar epithelial type type cells although cell type specific markers prominently surfactant protein allowed detailed lineage tracing studies cell differentiation cells roles disease studies cells hampered lack genes expression unique cells study performed genome wide expression profiling multiple rat organs together purified rat vitro differentiated like cells resulting identification candidate cell markers cross referencing genes regulated human vitro differentiated like cells narrowed potential list candidate genes testing top four candidate genes rna protein levels revealed gram domain gramd protein unknown function highly specific cells rna sequencing rnaseq confirmed gramd transcriptionally silent human cells immunofluorescence verified gramd expression restricted plasma membrane cells expressed bronchial epithelial cells whereas reverse transcription polymerase chain reaction confirmed expressed endothelial cells using gramd new cell specific gene enhance cell isolation investigation alveolar epithelial cell differentiation potential contribution cells distal lung diseases
purpose goal study develop korean version benefit satisfaction willingness continue bsw questionnaire original version subsequent linguistic validation korean patients overactive bladder undergo active treatment physician methods translation linguistic validation performed january validation process included permission translation forward translation reconciliation backward translation cognitive debriefing proofreading results forward translation process terms phrases benefit willingness benefit taking things account adjusted appropriate expressions korean language used original version backward translation process changes made terms sematic equivalence cognitive debriefing session patients asked fill answers within minutes reported translated questions clear easy understand one patient felt questions little bit difficult understand however panel decided change expressions overall level comprehension high translated terms accurate enough convey meaning original version bsw conclusions present study showed successful linguistic validation bsw questionnaire studies needed assess psychometric properties bsw
real time infrared simulation technology provide large number infrared images different conditions support design test evaluation system infrared imaging equipment low costs synthesizing heat transfer infrared physics fluid mechanics computer graphics real time infrared simulation method proposed based method characteristics predict infrared feature aircraft plumes tries obtain good balance simulation precision computation efficiency temperature pressure distribution expansion status rapidly solved dynamically changing flight statuses engine working states modified curtis godson spectral band model combines plume streamlines conventional spectral band model implemented calculate non uniformly distributed radiation parameters inside plume field simulation result analyzed compared cfd validates credibility efficiency proposed simulation method elsevier rights reserved
clinically important pharmacokinetic interference alendronate occurred new effervescent formulation alendronate levothyroxine coadministered combination materially affect levothyroxine absorption concurrent treatment osteoporosis alendronate aln hypothyroidism levothyroxine may problematic drugs taken separately fasting overnight primary objective assess pharmacokinetic interactions new effervescent formulation aln aln nef randomized open label way crossover study conducted healthy adults women subjects dosed times separated days overnight fasts aln nef alone alone aln nef concurrently samples analyzed plasma aln serum pharmacokinetic drug drug interaction assessed using confidence intervals cis test reference ratio geometric means area concentration time curve time zero last measureable time point auc maximum concentration max results compared default effect boundaries ratio aln nef concurrently aln nef alone ratio aln nef concurrently alone geometric mean ratios aln nef aln nef alone auc max demonstrating appreciably affect pharmacokinetics aln geometric mean ratios aln nef alone auc max demonstrating bioequivalent treatments coadministration aln nef well tolerated clinically important pharmacokinetic interference aln nef formulation aln nef materially affect absorption
present study investigated oxidative stress parameters antioxidant defence status perinatal hypothyroid rat liver heart found proteincarbonyl content differ significantly three groups pup liver heart level significantly decreased hypothyroid heart liver compared controls slight significant decrease sod activity observed perinatal hypothyroid liver heart significantly increased activity cat observed liver heart hypothyroid pups gpx activity considerably increased compared controls perinatal hypothyroid heart unaltered liver hypothyroid pups also found vitamin levels liver decreased significantly hypothyroidism unaltered heart perinatal hypothyroid rats gsh content elevated significantly hypothyroid liver heart total antioxidant capacity higher liver hypothyroid group hypothyroid heart thyroxine replacement could repair changes normal conclusion perinatal hypothyroidism modulates oxidative stress status perinatal liver heart
paper presents theoretical model addresses several issues related life cycle cost analysis illustrate time inconsistent preferences affect consumer choice particular case study selects involved consumer choice vehicle high initial acquisition cost low ownership cost electric vehicle one low initial acquisition cost high ownership cost conventional internal combustion engine vehicle icev test theoretical analysis conduct empirical study time discounting rates affect consumer choice icevs evs different initial cost ratios survey results find individuals higher present bias showed irrational purchase behavior even controlling wealth level specifically people making stronger bias present decisions chose higher total cost icevs lower initial cost higher ownership cost lower total cost evs higher initial cost lower ownership cost however people long term discount correlated irrational vehicle purchase behavior furthermore study present bias long term discount rate one scenario found present bias correlated irrational behavior elsevier ltd rights reserved
growing competitiveness commercial space market raised interest operating small spacecraft low altitudes make feasible space industry started developing propulsion options tailored specifically platforms paper presents review emerging micropropulsion technologies evaluates applicability microsatellite missions altitude range results proposed analysis demonstrated two different remote sensing applications
order study high low cycle fatigue experiment bench control technology certain type aircraft engine fan blade reach purpose reducing pressure pulsation system improving stability test loading force means simulation first designed experiment bench model high low cycle fatigue based matlab simhydraulics basis system model completed simulation according following steps changing position loading ways accumulator hydraulic test bench matching system different parameters study find simulation high low cycle fatigue test rig reached expected purpose time got effective parameter selection process simulation also found introduction accumulator give great buffer effect pressure pulsation produced sudden closing valves mean time accumulator bring stable loading force conclusion study provide necessary guidance design production experiment bench get better experiment results
empirical analyses testing impacts entrepreneurial orientation remain lacking public sector research despite strong normative expectations public managers foster culture innovativeness risk taking proactiveness accountability organizations drawing data nationwide survey local governments research uses structural equation modelling examine relationships organizational integration processes performance energy efficiency conservation block grant eecbg programme study finds positively influences programme performance indirectly enhancing knowledge sharing interorganizational collaboration performance information use practical theoretical implications discussed
advance investigation vegetated terrain using polarimetric remote sensing techniques important determine electromagnetic properties key constituents branches trunks may realistically modeled tapered cylinders end apply previously proposed virtual partition method vpm numerical simulations demonstrate vpm possesses desired features high fidelity prediction scattering amplitude function fulfillment energy conservation well reciprocity theorem thus may helpful pursuit better coherent scattering models vegetated terrain finer understanding polinsar imagery better characterization scattering mechanisms
paper presents infinity torque vectoring control formulation fully electric vehicle four individually controlled electric motor drives design controller based loop shaping state observer configuration discussed considering effect actuation dynamics gain scheduling controller parameters function vehicle speed implemented increased robustness infinity controller respect proportional integral controller analyzed including simulations different tire parameters vehicle inertial properties experimental results four wheel drive electric vehicle demonstrator board electric drivetrains show control formulation need feedforward contribution providing required cornering response steady state transient conditions authors published elsevier ltd
paper introduces overhead multi steel tube pole problems existing engineering application combined design operation experience steel tube pole selection design parameters steel tube pole design pay attention two aspects main points paper analyzed main technical points steel tube pole design liaoning province puts forward set overhead multi pole typical design scheme standardize construction management reasonable control engineering cost
micrornas mirnas well known powerful regulators gene expression potential serve circulating biomarkers widely accepted cardiovascular disease cvd numerous studies suggested mirnas strong circulating biomarkers high diagnostic well prognostic power coronary artery disease cad heart failure mirnas suggested reliable biomarkers matching established protein based cardiac troponins natriuretic peptides also cvd entities mirnas identified surprisingly specific biomarkers great potential clinical applicability especially entities lack specific protein based biomarkers atrial fibrillation acute pulmonary embolism ape regard mirna signatures comprising set mirnas yield high sensitivity specificity attempts utilize mirnas therapeutic agents led promising results article review clinical applicability circulating mirnas cvd giving overview mirnas biomarkers numerous cvd entities depict variety potential clinical deployment illustrate function mirnas means single mirna examples cvd
background complications related sickle cell disease scd result significant declines health related quality life hrqol hydroxyurea reduces scd complications adherence remains suboptimal study objectives assess feasibility internet based electronic assessment hrqol scd clinic examine relationship hrqol hydroxyurea adherence adolescents young adults ayas scd procedure cross sectional survey administered tablets ayas years old scd clinic january december study measures included patient reported outcomes measurement information system promis computerized adaptive testing modified morisky adherence scale items mmas results participants male black median age range years ninety one percent completed promis measures electronically clinic meeting feasibility criterion completion rate mmas scores positively correlated fetal hemoglobin hbf mean corpuscular volume mcv inversely correlated fatigue depression social isolation low mmas scores indicating poor adherence associated worse fatigue trended toward significance pain depression homozygous hemoglobin disease patients low hbf worse social isolation low mcv reported worse fatigue pain mobility social isolation conclusions hrqol assessment scd clinic feasible scd patients low hydroxyurea adherence low hbf mcv levels worse hrqol scores particularly fatigue future prospective studies examining relationship hrqol hydroxyurea adherence warranted
last years revolution social networks facebook twitter instagram led daily increasing data heterogeneous sources data models platforms heterogeneous data sources many forms www deep web relational databases systems sql database systems hierarchal data systems semistructured files data usually allocated different machines distributed different data models heterogeneous large scale data integration efforts demonstrate valuable contribution implementing data integration platform provides uniform access heterogeneous data sources well different versions data reported data source time furthermore platform must able integrate data broad range data authoring devices database management systems also accessible almost types data querying devices ensure globally querying integration platform place earth anytime receiving query result data format paper create resource oriented heterogeneous data integration platform rohdip facilitates data integration process implements objectives discussed use resource oriented architecture roa support uniform access types data querying devices anywhere improve query response time
impedance based model doubly fed induction generator dfig systems including rotor part rotor side converter rsc induction machine grid part grid side converter gsc output filter developed analysis mitigation subsynchronous resonance ssr however high frequency resonance hfr dfig systems due impedance interaction dfig system parallel compensated weak network often overlooked paper thus investigates impedance characteristics dfig systems analysis hfr influences rotor speed variation machine mutual inductance digital control delay evaluated two resonances phenomena revealed series hfr dfig system weak power grid parallel hfr rotor part grid part dfig system impedance modeling dfig system weak grid network well series hfr dfig system parallel compensated weak network validated experimental results
objectives disease modifying treatments dmts constitute largest direct medical cost multiple sclerosis study aims investigating predictors year economic burden dmt administration management materials methods study included newly diagnosed drug naive relapsing remitting rrms patients followed years costs dmt administration management calculated referred year observation annual costs possible predictors disease evolution categorized early predictors age gender disease duration baseline expanded disability status scale edss point edss progression within years annualized relapse rate arr within years long term predictors reaching edss conversion secondary progressive arr number dmts follow duration association predictors study outcome explored using mixed effects log linear regression models results point higher edss diagnosis associated increase annual costs additional year age diagnosis associated decrease annual costs female gender associated decrease annual costs converting associated decrease annual costs additional year follow associated decrease annual costs conclusions estimate year costs associated dmt administration management calculated analyzing different factors might particular interest planning resources needed treating people
objective study assessed changes anxiety different phases childbirth sample women demanding epidural anesthesia design prospective longitudinal case series sample total women demanded epidural anesthesia childbirth answered questionnaires methods anxiety state measured using state trait anxiety inventory stai questionnaire stai anxiety state administered three phases childbirth phase applying epidural anesthesia phase min application epidural anesthesia phase less delivery data collected two general hospitals third level public hospital well recognized private hospital main outcome measures stai scores results anxiety state decreases significantly applying epidural anesthesia phase compared anesthesia phase remains low levels childbirth phase statistically significant differences stai scores different phases administrated phases effect size phases effect size phase women cesarean section birth significant differences stai scores relative spontaneous birth type health care setting public private educational level numbers previous births affect level anxiety state women three phases conclusions women anxiety decreases significantly applying epidural anesthesia remains low delivery anxiety childbirth influenced health system used women condition primiparous multiparous educational level women received epidural anesthesia cesarean section reported higher rates anxiety state birth
examined effect combination antiretroviral therapy cart liver fibrosis among hiv infected patients without hepatitis hbv virus hcv infection retrospective cohort study hiv infected patients receiving cart liver fibrosis assessed using fibrosis fib score three classifications class participants hiv mono infected hiv hbv infected hiv hcv infected hiv hbv hcv infected participants received follow treatment median years improvement lower class observed class class respectively progression higher class observed class class respectively median time months improvement lower classes older age male dai ethnicity injection drug use hcv infection tenofovir treatment negative predictors class fib time updated increases count baseline positive predictors progression higher classes older age male jingpo ethnicity hcv infection positive predictors baseline count class fib negative predictors improvement lower class linked decreased mortality risk among patients class early cart initiation hiv infected patients without hepatitis infections may mitigate slow liver fibrosis special attention given older male infected hcv
aim study explore relation problematic gaming behaviour pgb specific psychological factors gaming motives self awareness problematic gaming behaviour structural factors game genres among finnish adolescents young adults national survey respondents aged participated study study sample randomly selected population register center multiple regression analysis used means examining links game genres gaming motives pgb addition pairwise comparisons non problematic gaming behavior group problematic gaming behavior group used means examining differences across game genre use self awareness pgb pgb particularly associated use group games encompassing role playing progression character development action strategy features findings indicated entertainment achievement social escapism motives associated pgb whole study emphasized specific game genres playing motives involved problematic use digital game playing
article points security loophole shi quantum blind signature scheme using modification attack message owner cheat signature receiver fake message signature pair without detected
pore networks considering variable connectivity geometrical restrictions among voids assorted sizes simulated using multicore computing system topology resulting networks visualized terms sizes connectivity pores color graphics results allow calculation percolation thresholds correlation lengths among pores fractal dimensions percolation clusters conditional probabilities among connected pore sizes besides possible observe disconnected pore islands different sizes depending structural correlation among pores elsevier rights reserved
low cost high performance vision sensors conjunction aerial sensing platforms providing new possibilities achieving autonomous visual inspection civil engineering structures large volume images given structure readily collected use visual inspection overcoming spatial temporal limitations associated human based inspection although researchers explored several algorithms techniques visionbased inspection recent decades major challenge past implementations lies dealing high volume images small fraction important actual inspection processing irrelevant images generate significant number falsepositives automated visual inspection techniques used coordination methods localize relevant regions images combined automated visual inspection able meet objectives quality human visual inspection enable technology develop validate novel automated image localization technique extract regions interest rois images utilizing vision based damage detection techniques rois portions image contain physical region structure targeted visual interrogation denoted targeted region interest tri rois computed based geometric relationship collected images tris analysis highly relevant localized images would enable efficient reliable visual inspection successfully demonstrate capability technique extract rois using full scale highway sign structure case weld connections serve tris
field programmable analog array fpaa using standard cmos wide dynamic range translinear element introduced fpaa configurable analog blocks cabs based reconfigurable translinear cell rtc capable implementing basic circuit elements required translinear log domain circuit design interfacing provided programmable cell allows easier connectivity signal processing core external circuitry proof concept rtc fpaa testchip implemented cmos technology set various circuit primitives one four quadrant multipliers euclidean distance operator fourth order log domain filter mapped chip order demonstrate versatility approach fpaa bandwidth reaches mhz power consumption precision errors
phast software package written standard fortran mpi cuda extensions able efficiently perform parallel multicanonical monte carlo simulations single multiple heteropolymeric chains coarse grained models proteins outcome data straightforwardly analyzed within microcanonical statistical thermodynamics module allows computing entropy caloric curve specific heat free energies case study investigate aggregation heteropolymers bioinspired beta fragments cross seeding iapp isoforms excellent parallel scaling observed even numerically difficult first order like phase transitions properly described built fully reconfigurable force fields still package free open source shall motivate users readily adapt specific purposes elsevier rights reserved
polycythemia vera essential thrombocytosis myelofibrosis chronic philadelphia negative myeloproliferative neoplasms characterized clonal hematopoiesis splenomegaly risk hemorrhagic thrombotic sequelae profound symptom burden review outcomes myeloproliferative neoplasm patients treated pegylated interferon alpha study academic medical center treated polycythemia vera essential thrombocytosis patients complete partial response obtained patients per eln iwg mrt revised criteria polycythemia vera patients becoming phlebotomy independent essential thrombocytosis patients platelet normalization therapy treated myelofibrosis patients stable disease seen patients vascular events occurred treated patients therapy grade toxicity uncommon leukopenia noted patient common adverse event overall grade fatigue retrospective single center analysis demonstrates pegylated interferon alpha active well tolerated therapy outside support clinical trial results substantiate previously reported efficacy pegylated interferon alpha myeloproliferative neoplasms prospective randomized clinical trial data required better delineate pegylated interferon alpha use myeloproliferative disease emphasis placed comprehensive molecular characterization allelic burden quantification measurement histologic response elsevier ltd rights reserved
based extended homoclinic test technique hirota bilinear method dimensional boiti leonmanna pempinelli equation investigated describes fluid propagating considered model incompressible fluid aid symbolic computation introduce two new ansatz functions discuss multiple periodic soliton solutions dimensional boiti leon manna pempinelli equation entirely new periodicsoliton solutions presented figures corresponding solutions illustrated show abundant physics structures
quantity potential potable water savings ppws made using rainwater harvesting differs municipalities within region three main parameters contribute difference roof area number inhabitants rainwater use scenarios article proposes spatial numerical analysis parameters influence ppws across municipalities paris agglomeration comparison location municipalities ppws value values previous parameters used understand observed difference spatial analysis shows municipalities districts paris highest ppws values contrary peripheral municipalities outer suburbs lowest ppws values results intermediary municipalitiesin inner suburbsare contrasting numerical analysis demonstrates strong correlation main parameters influencing ppws value high value roof area means high value number inhabitants good mix rainwater use scenarios vice versa conclusion planning design municipalitybuilding density types buildings number inhabitants city vocationare key factors defining level ppws made using rainwater harvesting
background introduction anti tumor necrosis factor anti tnf alpha drugs improved clinical outcomes rheumatoid arthritis ankylosing spondylitis however drugs may cause adverse effects motivate change discontinuation treatment objective evaluate causes discontinuation changes dosage regimen cohort patients treated infliximab adalimumab etanercept golimumab clinical practice conditions methods retrospective observational study included patients treated anti tnf alpha drugs changes dosage regimen reasons treatment discontinuation adverse effects recorded analyzed time discontinuation estimated using kaplan meier survival analysis results total patients patients treated anti tnf alpha therapy study patients patients stopped treatment frequent changes modifications dosing frequent adverse effects reactions infusion injection respectively drug survival etanercept greater adalimumab infliximab whereas drug survival infliximab greater etanercept adalimumab years although significant differences conclusions main cause discontinuation anti tnf alpha therapeutic failure diseases etanercept infliximab best survival rates respectively
non uniform section phaser introduced powerful approach enhance design flexibility uniform phasers moreover efficient synthesis technique provided design phasers two design examples presented first example single non uniform section phaser second one cascaded double non uniform section phaser featuring larger group delay swing bandwidth hence higher resolution radio analog signal processing asp
indoor tanning linked psychiatric addictive symptoms frequent tanning may indicate tanning dependence addiction current study evaluated effects episode mood states association effects psychiatric addictive symptoms among young adult female indoor tanners one hundred thirty nine female university students aged years indoor tanned completed online survey including positive negative affects scales standardized psychiatric interview mini international neuropsychiatric interview via telephone psychiatric addictive symptoms relatively common among young adult female indoor tanners overall participants reported significant decreases negative upset scared irritable nervous jittery afraid positive feeling interested mood states recent tanning episode multivariable linear regression analyses showed frequent indoor tanning past month symptoms illicit drug use disorders associated decreases negative mood symptoms generalized anxiety disorder associated decrease feeling interested summary indoor tanners report relatively high rates psychiatric substance use symptoms including symptoms tanning dependence indoor tanning appears alter mood women certain substance use psychiatric characteristics may vulnerable mood changes tanning indoors research needed clarify relationships among variables
ambient intelligence ami currently perspective area development intelligent systems react human presence behavior ami adapts requirements based contextual knowledge important issue study ami thinking context aware preference context ubiquitous computing technologies access users system one point different contexts creates need context sensitive preferences aim context reasoning getting new knowledge systems services intelligent process trivial problem propose multidimensional view context aware knowledge support contextual reasoning paper introduce new tcap procedure transformation context aware preference olap ami olap technology enables better analyzing contextual dependence preferences choosing relevant content users ami environment
chronotype emerging predictor health longevity understanding influence chronic diseases important constructing conceptual models long term pathways health assessed associations chronotype health status general finnish adult population population based data derived national finrisk study consisted participants aged years living finland part health examination participants asked circadian preference daily activities morningness eveningness diagnosis treatment set common noncommunicable medical conditions chronic diseases past months found morning types mts evening types ets intermediates compared mts ets significantly greater odds depression mental disorders odds also increased gallstones chronic obstructive pulmonary disease remain significant controlling multiple testing responses single item subjective estimation chronotype yielded association definitely evening type persons diagnosis treatment cardiac insufficiency corroborated greater eveningness score common diagnosis treatment cardiac insufficiency beta exploratory study adds support role evening chronotype chronic disease risk albeit underlying mechanisms remain elucidated
background dsm reactive attachment disorder rad disinhibited social engagement disorder dsed rare understudied controversial disorders methods comorbidity children diagnosed rad dsed compared comorbidity adhd autism determine rad dsed comorbidity differed two common disorders child psychiatric clinics samples included year olds rad dsed autism adhd children rad dsed removed neglectful environments mean years mean years studied mothers rated children pediatric behavior scale assessing oppositional behavior conduct problems adhd anxiety depression symptoms results five children rad dsed dsed without rad rad dsed none rad without dsed children rad callous unemotional traits conduct disorder children dsed rad children rad dsed considerably impaired children dsed rad autism adhd conclusions findings consistent studies indicating high comorbidity rad extreme rarity rad without dsed findings noted dsm elsevier ltd rights reserved
article presents model australian social work unaccompanied asylum seeking young people aims build hope agency meaning social worker young person informed foucault understanding resistance model encourages social workers pay attention little practices freedom development professional relationships address counselling needs practical advocacy social change within complex socio political cultural therapeutic contexts case vignette ali applies model practice article concludes exploration model potential international transferability
two experiments examined extent erroneous recall blocks veridical recall using vehicle study disruptive impact distractors semantically similar list words presented free recall instructing participants avoid erroneous recall ignored spoken distractors attenuated recall influence disruptive effect distractors veridical recall experiment using externalized output editing procedure whereby participants recalled items came mind identified erroneous usual sequences semantic similarity effect erroneous veridical recall replicated hut relationship rate erroneous veridical recall weak experiment results suggest forgetting due veridical recall blocked similar events
explore possible correlations among brain lesion location development psychiatric symptoms use antiepileptic drugs aeds population patients brain tumor epilepsy medical records patients various types brain tumor mean age years analysed retrospectively patients grade iii glioma previous history epileptic seizures psychiatric disorders excluded psychiatric symptoms occurring initiation aed therapy considered treatment emergent psychiatric adverse events paes fulfilled following conditions onset within weeks beginning aed therapy disappearance drug discontinuation absence identified possible concurrent cause possible influence following variables analysed aed drug dose location neuroradiologic features tumor location type eeg epileptic abnormalities tumor excision already yet performed initiation radiotherapy paes occurred aed treated patients multivariate analysis showed significant association paes occurrence location tumor frontal lobe odds ratio confidence interval value treatment levetiracetam odds ratio confidence interval value drug unrelated acute psychiatric symptoms observed aed untreated patients aed treated patients results present study suggest aed alternative levetiracetam chosen treat epileptic seizures patients brain tumor located frontal lobe minimize possible onset paes
background despite huge epidemiological impact primary headaches trigeminal neuralgia chronic pain conditions still receive suboptimal medical approach even developed countries limited efficacy current pain killers prophylactic treatments stands among main reasons phenomenon botulinum neurotoxin bont represents well established licensed treatment chronic migraine also emerging treatment types primary headache trigeminal neuralgia neuropathic pain increasing number pain conditions methods searched critically reviewed evidence efficacy bont treatment chronic pain results meta analyses randomized controlled trials rcts suggest bont potentially represents multi purpose drug treatment pain several disorders due favorable safety profile long lasting relief single injection conclusions bont emerging treatment different pain conditions future rcts explore use bont injection therapy combined systemic drugs physical therapies new pain treatment strategies
health well consequences social isolation loneliness old age increasingly recognised purpose scoping review take stock available evidence highlight gaps areas future research searched nine databases empirical papers investigating impact social isolation loneliness range health outcomes old age search conducted july september yielded articles items countries included scoping review papers reviewed focus definitions measurements two concepts associations causal mechanisms differences across population groups interventions evidence largely focused loneliness researched social isolation recent trend investigation comparative effects social isolation loneliness depression cardiovascular health often researched outcomes followed well almost two studies found detrimental effect isolation loneliness health however causal links mechanisms difficult demonstrate investigation warranted found paucity research focusing risk sub groups area interventions future research aim better link evidence risk factors loneliness social isolation evidence impact health
background delays access health care canada reported standardized systems manage monitor wait lists wait times benchmarks appropriate wait times lacking objective present consensus develop evidence expertise based recommendations medically appropriate maximal wait times consultation procedures digestive disease specialist methods steering committee drafted statements defining maximal wait times specialist consultation procedures based common reasons referral adult patients digestive disease specialist statements circulated advance multidisciplinary group participants comments voting consensus meeting relevant data results voting presented discussed formed basis final wording voting statements results twenty four statements produced regarding maximal medically appropriate wait times specialist consultation procedures based presenting signs symptoms referred patients statements covered areas gastrointestinal bleeding cancer confirmation screening surveillance colon cancer colonic polyps liver biliary pancreatic disorders dysphagia dyspepsia abdominal pain bowel dysfunction suspected inflammatory bowel disease maximal wait times could stratified four possible acuity categories two weeks two months six months future directions comparison benchmarks actual wait times identify limitations access digestive heath care canada recommendations considered targets future health care improvements clinical practice guidelines
background paucity research correlates child maltreatment limited resource countries relatively high tolerance harsh discipline vietnamese study aimed investigate associations different types child maltreatment child emotional cognitive physical health functioning well moderation effects gender ethnicity methods cross sectional study conducted randomly selected students aged years self report objective measures weight height study ranking memory test used results types child maltreatment associated emotional dysfunctioning life time past year experiences physical abuse life time experiences sexual abuse neglect related poorer perceived physical health study find associations type child maltreatment overweight underweight status regarding cognitive functioning life time experience sexual abuse neglect related poorer working memory performance noticeably emotional abuse related better academic performance might indication tiger parenting practice vietnam implying academic performance stimulation expense emotional security significant moderation effects gender ethnicity found conclusion even culture harsh discipline normative child maltreatment related negative aspects child wellbeing including emotional cognitive physical health functioning efficient low cost interventions child maltreatment developed conducted vietnam well countries similar contexts
objective previous studies demonstrated presence active trigger points trps women migraine reproducing headache attacks study investigated whether trps alter cervical muscle function migraine objective analyze differences activation superficial neck flexor extensor muscles women migraine considering presence active trps splenius capitis upper trapezius sternocleidomastoid scm muscles methods surface electromyography emg recorded superficial flexors scm anterior scalene extensor muscles bilaterally participants performed staged task cranio cervical flexion ccf contractions representing progressive increase ccf range motion women migraine stratified according presence absence active trps scm musculature comparison emg normalized root mean square rms values conducted analysis covariance task level within subject variable group stratified active trps subjects variable presence neck pain covariable results patients exhibited active trps cervical muscles reproduced migraine women migraine exhibiting active trps scm muscles lower normalized rms values superficial neck flexors without active trps muscles addition individuals exhibiting active trps muscles higher normalized rms values muscle without active trps muscles conclusions presence active trps cervical musculature determines altered activation superficial neck extensor muscles low load isometric ccf contractions women migraine
disrupted oppositional based gravitational search algorithm dogsa tuned sliding mode controller smc proposed study solution automatic generation control interconnected multi area power system deregulated environment novelty control scheme established performing sensitivity analysis different conditions variation system load turbine time constant governor time constant tie line power coefficient dynamic response system consideration also studied analysed presence non linear constraints namely generation rate constraint reheat steam turbine governor deadband time delay signal processing order validate effectiveness proposed dogsa tuning genetic algorithm differential evolution tuned schemes reported literature also employed tune integral proportional integral integral derivative proportional integral derivative pid controllers moreover performance optimised smc scheme also compared pid controllers comparative results reveal smc scheme tuned using dogsa gives better results conventional controllers
polyaniline powder nanosize synthesized chemical oxidative route xrd ftir tem used characterize polyaniline powder crytallite size estimated xrd profile also ascertained tem range composite absorbers prepared mixing different ratios polyaniline procured polyurethane binder complex permittivity epsilon epsilon complex permeability measured band ghz using agilent network analyzer model pna software module version measured values parameters used determine reflection loss different frequencies sample thicknesses based model single layered plane wave absorber backed perfect conductor optimized polyaniline ratio given minimum reflection loss power absorption central frequency ghz bandwidth full width half minimum ghz whole band ghz sample thickness prepared composites fruitfully utilized suppression electromagnetic interference emi reduction radar signatures stealth technology
purpose demonstrate potential simple clinical test hamstring muscle strength identify susceptibility muscle strain injury methods single case design used specifically elite level male australian rules football player performed bilateral isometric maximum voluntary contractions hamstring muscles weekly basis period weeks preceding right hamstring muscle strain injury results minimal asymmetry greater difference evident hamstring isometric maximum voluntary contractions first weeks days prior injury right hamstring isometric maximum voluntary contraction reduced compared left conclusion measuring asymmetry isometric maximum voluntary contractions hamstring muscles may useful clinical test identify susceptibility muscle strain injury
imbalance data defined dataset whose proportion classes severely skewed classification performance existing models tends deteriorate due class distribution imbalance addition representation majority classes prevents classifier paying attention minority classes generally interesting effective ensemble classification method called rhsboost proposed address imbalance classification problem classification rule uses random undersampling rose sampling boosting scheme according experimental results rhsboost appears attractive classification model imbalance data elsevier rights reserved
research shows mathematics anxiety mathematics achievement present challenge many educators particularly elementary school teachers usually lower mathematics content knowledge higher math anxiety levels average college students study investigated education majors cognitive abilities mathematics perceptions affect mathematics performance geometry word problem solving non word problem solving examined relationships mathematics problem solving math anxiety three mathematical domains function working memory spatial ability attitudes toward learning mathematics math anxiety spatial ability explained variance student overall mathematics performance math anxiety highest negative predictor although relationships math anxiety mathematics performance varied mathematical domain negative effects math anxiety equally detrimental three mathematical domains even controlling effects performance spatial ability elsevier inc rights reserved
article reports algebraic criterion eigenvalue assignment transversality condition non resonance condition fold bifurcations means symbolic computation methods propose algorithmic approach systematically analyzing codimension bifurcations high dimensional discrete systems effectiveness proposed symbolic approach verified experiments particular flip fold bifurcations five dimensional discrete dynamical system washout filter feedback controller analyzed elsevier inc rights reserved
background lower urinary tract symptoms luts men common clinical problem urology historically strictly linked benign prostatic hyperplasia bph may lead bladder outlet obstruction boo new molecules approved entered urologists armamentarium targeting new signaling pathways tackling specific aspects luts objective review summarize evidence regarding new medical therapies currently available male non neurogenic luts including superselective antagonists pde inhibitors anticholinergic drugs intraprostatic onabotulinum toxin injections methods national library medicine database searched relevant articles published january december including combination bph luts medical new article title abstract text reviewed appropriateness relevance one hundred forty eight articles reviewed results articles reviewed excluded silodosin may considered valid alternative nonselective alpha antagonists especially older patients blood pressure alterations may determine major clinical problems ejaculatory alterations may truly bothersome tadalafil causes significant decrease ipss score amelioration patients qol although significant increase max antimuscarinic drugs effective storage symptoms used caution patients elevated post void residual intraprostatic injections botulinum toxin well tolerated effective low rate adverse events however profound ameliorations seen also sham arms rcts evaluating intraprostatic injections conclusion new drugs approved last years medical treatment bph related luts practicing urologists familair pharmacodynamics pharmacokinetics
background long non coding rnas lncrnas confirmed play important role development progression diseases ankylosing spondylitis chronic inflammatory systemic disease hard found early time purpose study investigate role lncrna diagnosis material methods expression lncrna detected quantitative real time polymerase chain reaction qrtpcr analysis relationship expression clinicopathologic characteristics also analyzed meanwhile correlation lncrna expression diseases activity indexes estimated addition value diagnosis explored establishing receiver operating characteristic roc curve results serum lncrna expression decreased patients compared healthy individuals expression proved influenced ever cigarette smoker exercise level occupational activity level besides correlation expression lncrna disease activity indexes basdi asdas esr crp negative suggested lncrna significantly lower patients high disease activity score might showed expression lncrna affected activity conclusions lncrna regulated patients could independent diagnostic indicator
research work presented preliminary prototype ambient intelligence scenario based cyber physical systems improving learning tasks system proposed composed cyberglove worktable rfid nfc detection zones ami software application modeling workflow guidance authors carried case study mentally handicapped people trainers involved executing workflows creation performing controlling tasks results obtained indicate kind solutions feasible due problem complexity fact proposed solution preliminary version found many issues solved next versions research helped uncover issues design better system
external difference families edfs type combinatorial designs originated cryptography many combinatorial objects closely related edfs difference sets difference families almost difference sets difference systems sets constructing edfs thus significance theory practice paper earlier ideas constructing edfs proposed chang ding huang explored consequently new infinite classes edfs obtained previously known results extended wiley periodicals inc
paper presents division summation sigma digital control based modular multilevel converter modular multilevel converters mmc applied static synchronous compensators statcom high voltage direct current transmission hvdct back back power transfer systems wind solar power generation battery storage systems sigma digital control adopted track current reference balance bus capacitor voltage regulate cell module capacitor voltage adopted sigma digital control accommodate wide filter inductance variation take care source voltage harmonics achieve fast tracking response low distortion output current applications active reactive power injection rectification power factor correction based power balance principle combination offset current current arm determined according charge balance principle sigma digital control bus capacitor voltage balancing cell voltage regulation achieved ensure output current low harmonics limitation factor cell voltage regulation discussed paper mmc configuration introduced first control laws current tracking voltage regulation derived detail simulated experimental results obtained mmc verified analysis discussion
paper concerned problem finding sparse graph capturing conditional dependence entries gaussian random vector available information sample correlation matrix popular approach address problem graphical lasso technique employs sparsity promoting regularization term paper derives simple condition computationally expensive graphical lasso behaves simple heuristic method thresholding condition depends solution graphical lasso makes direct use sample correlation matrix regularization coefficient proved condition always satisfied solution graphical lasso close first order taylor approximation equivalently regularization term relatively large condition tested several random problems shown graphical lasso thresholding method lead highly similar results case sparse graph sought also conduct two case studies brain connectivity networks twenty subjects based fmri data topology identification electrical circuits support findings work similarity graphical lasso thresholding
nearly years since rabinow artificiality enlightenment sociobiology biosociality scholarly attention biosociality related concepts biological citizenship expanded foucault theories biopolitics updating century commentary explicate new biopolitical theories propose schema operationalizing deductive analyses ethnographic research illustrate way schema may applied examples ethnographic study autism italy provide model new biopolitical theory used future projects variety research settings put scholarship biosocialities biological citizenships explicit conversation robust conversation scholarly understanding biopolitics general local particularity biologies biomedicines politics affect
paper presents development compact six axis magnetic levitation stage including design implementation magnetic actuators laser interferometer motion sensors motion controllers designed travel volume stage translation rotation two axis linear actuator based magnetic lorentz force law designed three two axis actuators equivalent six single axis actuators implemented achieve six axis actuation high resolution laser interferometer measurement system implemented employed measure six axis motion stage facilitating real time feedback control feedback linearization based rigid body dynamics levitated stage force distribution implemented computer controlled architecture establish decoupled dynamics six computed inputs resulting six axis motions constant gain controllers designed implemented according concept loop shaping six axes high positioning stability root mean square rms rms achieved experimental results presented illustrate positioning stability system linearity dynamic response invariance nano stepping multiaxis contouring large rotational motion
higher education pressure advance singular focus assessment outputs measurements encompass impact influence initiatives across aspects academic endeavour research learning teaching leadership paper focuses implications shift leadership higher education demonstrating impact leadership higher education requires taking step beyond measuring skills behaviours achievements individual leaders demonstrating universities evaluate impact actions taken build leadership capacity across institution authors extend outcome empirical research distributed leadership approach enabled evaluated australian higher education analyse effectiveness processes measuring output assessing impact influence practice
island city state singapore futuristic industrialized densely populated port city water independence central security national government devotes considerable resources mobilizing urban surface waters major rivers integrated technologically sophisticated aquatic enclave called hydrohub recreational educational spaces aesthetically designed system contribute public acceptance radically altered ecosystem drawing ethnographic fieldwork show flash floods undermine dominant cultural political technical registers systematically emphasize hydrohub benefits hydrohub frames sustainability set interior problems solved assuring clean water preventing flooding disregarding possible unintended consequences excluding exterior probable decline biodiversity fishery resources yet enclave ecologies hydrohub may become increasingly popular model given worldwide water pollution sea level rise accompanying climate change bringing technical aspects engineering cultural analyses applied anthropologists effectively reveal trade offs associated ecological enclaves contribute models sustainability better integrate maritime surround urban fabric islands coasts
introduction biologic antagonists tumor necrosis factor alpha tnf alpha effective medications become well established treatment crohn disease ulcerative colitis biosimilar medications medications deemed equivalent reference biologic products terms clinical effectiveness safety pharmacokinetic analysis immunogenicity approved inflammatory bowel diseases ibd based indication exploration clinical data alternate disease states clinicians use products caution secondary lack clinical experience areas covered authors performed literature search using following keywords biosimilar adalimumab infliximab abp inflammatory bowel disease bibliographies also reviewed pertinent articles articles pertaining clinical efficacy biosimilars ibd included expert commentary phase trials provided clinical justification bring tnf alpha biosimilars market rheumatoid arthritis ankylosing spondylitis however new clinical data suggests biosimilar products equivalent safety efficacy reference products ibd led increased acceptance amongst practicing gastroenterologists potential reduction healthcare costs
role androgen deficiency biological determinant frailty received considerable attention cross sectional studies shown low bioavailable testosterone associated prevalent frailty high levels luteinizing hormone sex hormone binding globulin also associated prevalent frailty longitudinal studies mixed results suggesting part decline time associated progression frailty number potential biases found current body evidence including misclassification bias due testosterone assays insensitive lower ranges selection bias due preferential inclusion healthier individuals residual confounding due correlation low testosterone several disease states adverse health characteristics consideration biases vital ensure future epidemiological studies interventional trials generate valid conclusions
made use special algorithm compute unified device architecture nvidia graphics cards nonlinear conjugate gradient method minimize energy functional monte carlo technique directly observe forming ground state configuration hard core bosons lowering temperature evolution deviation away half filling novel technique allowed examine earlier implications uncover novel features phase transitions particular look upon nucleation odd domain structure emergence filamentary superfluidity nucleated antiphase domain walls charge ordered phase nucleation evolution different topological structures
recent fdopa pet study reports negative correlations dopamine synthesis rates aggressive behavior since dopamine among substrates monoamine oxidase maoa investigation examines whether functional allelic variants maoa tandem repeat vntr promotor polymorphism known modulate aggressive behavior influences dopamine release aggression response violent visual stimuli selected genetic prescreening sample strictly case matched groups healthy male subjects vntrs predictive high maoa high low maoa low maoa expression subjects underwent pairs pet sessions dopamine ligand dmfp viewing movie neutral content versus violent content directly afterwards aggressive behavior assessed point subtraction aggression paradigm psap finally pet data participants behavioral data participants analyzed due post hoc exclusion criteria genetic prescreening sample maoa low carriers significantly increased scores buss perry aggression questionnaire pet study group aggressive behavior emotional neutral condition significantly higher maoa low group interestingly two maoa groups showed inverse dopaminergic behavioral reactions violent movie maoa high group showed higher dopamine release increased aggression violent movie maoa low subjects showed decreases aggressive behavior consistent dopamine release results indicate possible impact maoa promotor polymorphism neurobiological modulation aggressive behavior however data support approaches stating maoa low fosters aggression simple pro dopaminergic mechanism elsevier inc rights reserved
protein brain derived neurotrophic factor bdnf plays important role diverse memory processes strongly expressed hippocampus hippocampus key structure involved processing information short term long term memory due putative role bdnf memory consolidation prominent single nucleotide polymorphism snp bdnf gene bdnf valmet investigated context long term memory performance students presented words categories consisting eight words fruits vehicles memory recognition task specifically deese roediger mcdermott paradigm recognition performance analyzed min initial presentation word list subsequently week initial presentation overall individual long term memory performance immediately learning word list performance week later differ basis bdnf snp interaction effect bdnf valmet time recall found carriers met variant showed strongest decline hit rate performance time
experiments crossover design subjects apply one treatment crossover designs widespread software engineering experimentation require fewer subjects control variability among subjects however researchers disapprove crossover designs main criticisms carryover threat troublesome analysis carryover persistence effect one treatment another treatment applied later may invalidate results experiment additionally crossover designs often properly designed analysed limiting validity results paper aim make researchers aware perils crossover experiments provide risk avoidance good practices study another discipline medicine runs crossover experiments review literature discuss good practices tend adhered giving advice applied experiments illustrate concepts discussed analysing crossover experiment run conclude crossover experiments yield valid results provided properly designed analysed correctly addressed carryover worse validity threats
past work political impact racial diversity focused direct effects demonstrating diverse environments associated negativeor circumstances positiveracial attitudes race targeted policy preferences show diversity functions second way variable magnifies political impact individual differences psychological disposition authoritarianism using national sample find white areas minimal diversity authoritarianism impact racial prejudice political intolerance attitudes toward immigration diversity rises however authoritarianism plays increasingly dominant role political judgment diverse environments authoritarians become racially ethnically politically intolerant nonauthoritarians less conceptually replicate findings dorm setting plausibly exogenous levels local diversity discuss implications findings terms various ways ethno racial diversity structures political attitudes
ankle rearfoot complex consists ankle subtalar joints observational study two test conditions rearfoot complex using high speed biplane fluoroscopy present method measure rearfoot kinematics normal gait compare rearfoot kinematics barefoot shod gait six male subjects completed walking trial biplane fluoroscopy images acquired stance phase bone models calcaneus tibia reconstructed computed tomography images aligned biplane fluoroscopy images optimization algorithm used determine three dimensional position bones calculate rearfoot kinematics peak plantarflexion higher barefoot degrees shod degrees neutral plantar dorsiflexion occurred later stance phase barefoot shod barefoot walking compared shod walking eversion peak degrees occurred stance barefoot walking shod walking brief inversion degrees occurred earlier stance stance phase tibia internally rotated relative calcaneus throughout stance phase conditions barefoot degrees shod degrees biplane fluoroscopy allow detailed quantification dynamic vivo ankle kinematics barefoot shod walking conditions methodology could used future study hindfoot pathology trauma congenital disease sports injuries instability
paper presents new high performance current differencing transconductance amplifier cdta recently reported active element especially suitable analog signal processing applications proposed cdta provide high output impedances port excellent input output current tracking proposed cdta circuit operats supply voltages pspice simulation results using tsmc cmos process model included verify expected values example application using proposed transadmittance type biquad filter also presented proposed filter realize filter responses topology circuit also requires component matching conditions
paper emi filter first characterized parameters based parameters model insertion voltage gain emi filters arbitrary source load impedances derived experiments carried verify approach parameters current bias also measured characterize emi filter current bias conditions concept waves used interpret impedance requirement filters finally predictions filter insertion voltage gain practical source impedances compared results measurement effects source impedances analyzed
invasive fungal infections usually aspergillus candida represent major cause morbidity mortality patients malignant haematological diseases last years rare fungal infections frequently reported report clinical history three patients affected haematological malignancies developed infection caused geotrichum clavatum two three patients affected acute myeloid leukaemia aml one mantle cell lymphoma mcl patients received cytarabine based chemotherapeutic regimens developed clavatum infection within weeks therapy initiation cases clavatum isolated central venous catheter peripheral blood cultures vitro susceptibility test confirmed intrinsic resistance echinocandins cases visceral localisations spleen liver lung documented total body computed tomography scan prolonged antifungal therapy high doses liposomal amphotericin necessary obtain fever resolution patient mcl died two aml recovered one received allogeneic stem cell transplantation consecutively reviewed published cases infection caused clavatum experience literature review indicate clavatum cause invasive infection haematological patients mainly acute leukaemia
psychopathic individuals account substantial predatory impulsive violence present principal intervention used decrease harm inflicted psychopaths confinement nevertheless confined psychopathic persons return community recent advances understanding neurobiology psychopathy hold promise new research directions effective treatments article explore recent advances genetics electrophysiology brain imaging psychopharmacology well brief implications new directions research treatment
understanding discharge capacity channels changes hydraulic properties large storms essential prediction flash floods however information limited steep mountain channels complex nature lack measured data thus obtained detailed water level surface velocity data large floods steep mountain channel documented complex channel morphology affected water flow large storms installed water level surface velocity sensors cascade pool downstream aono research forest arboricultural research institute university tokyo forests japan successfully obtained min interval data major storm total precipitation fell maximum rainfall intensity storm height water surface deepest point cross section ranged surface velocity ranged expected changes flow depth surface velocity velocity profiles complex differed even cascade adjacent pool cross sections dramatic changes flow conditions first occurred cascade discharge increased certain point water suddenly stagnated foot cascade submerged flow might occurred thereafter water level increased remarkably surface velocity velocity profile stayed almost constant cascade cross section downstream pool rocks submerged mean water depth surface velocity suddenly increased dramatically velocity profile changed slow flow developed lower portion profile water levels increased slightly rainfall diminished first surface velocity markedly declined velocity profile returned original state pool submerged flow bottom cascade ceased temporally spatially detailed flow measurements effectively document characterize flow conditions large flood steep mountain channel field data confirm long held hypothesis marked changes flow conditions occur steps become submerged elsevier rights reserved
background wearable sensors potential provide clinicians access motor performance people movement disorder undergo intervention however sensor data often manually classified segmented processed clinical metrics process time consuming recently proposed detection segmentation algorithms based peak detection using inertial measurement units imus automatically identify isolate common activities daily living standing walking turning sitting algorithms developed using homogenous population healthy older adults aim study investigate transferability algorithms people parkinson disease methods modified timed task used since comprised activities performed continuous fashion twelve older adults diagnosed early hoehn yahr recruited study performed three trials tug state outfitted imus covering body segment raw data imus detrended normalized filtered reveal kinematics peaks corresponded different activities segmentation accomplished identifying first minimum maximum right left peaks segmentation times compared results two examiners visually segmented activities specificity sensitivity used evaluate accuracy detection algorithms results using imus algorithms developed previous study able detect activities sensitivity specificity population however modifications imus selection able detect activities accuracy similarly applying segmentation population able isolate activities within similar visual segmentation optimizing filtering frequencies able reduce difference similar conclusions study demonstrates agility transferability using system imus accurately detect segment activities daily living people movement disorders
covert channel major threat information system security commonly found operating systems especially cloud computing environment owing characteristics cloud computing environment resources sharing logic boundaries covert channels become varied difficult find focusing problems paper presents universal method detecting covert channel automatically achieve global detection leveraged virtual machine event record mechanism hypervisor gather necessary metadata combining shared resources matrix methodology events association mechanism proposed distinctive algorithm accurately locate analyze malicious covert channels respect behaviors compared popular statistical test methods focusing single covert channel method capable recognizing detecting covert channels real time experimental results show method able detect multilevel multiform covert channels cloud environment effectively also facilitates implementation deployment practical scenarios without modifying existing system copyright john wiley sons ltd
ambient intelligence promises transform current spaces electronic environments responsive assistive sensitive human presence electronic environments fully populated dozens hundreds even thousands connected devices share information thus become intelligent massive wave electronic devices also invade everyday objects turning smart entities keeping native features characteristics seamlessly promoting new class thinking reasoning everyday objects although strong expectations users needs fulfilled without intervention still situations interaction required paper presents work done field human computer interaction focusing smart home environments part larger project called aging inside smart home initiative arose way deal large scourge country lots elderly persons live alone homes often limited physical mobility project relies mobile agent computing paradigm order create virtual butler provides interface elderly smart home infrastructure virtual butler receptive user questions answering according context knowledge aish also capable interacting user whenever senses something gone wrong notifying next kin medical services etc virtual butler aware user location moves computing device closest user order always present avatar also run handheld devices keeping main functionality order track user goes according evaluation carried virtual butler assessed interesting loved digital friend filling gap user smart home evaluation also showed virtual butler concept easily ported types possible smart assistive environments like airports hospitals shopping malls offices etc
paper propose novel low level structure feature extraction image processing based deep neural network stacked sparse denoising autoencoder ssda current image processing methods via deep learning directly building learning end end mappings input output instead advocate analysis first layer learning features input data learned low level structure features improve two edge preserving filters key image processing tasks denoising high dynamic range hdr compression details enhancement due validity superiority proposed feature extraction results computed two improved filters suffer drawbacks including halos edge blurring noise amplification enhancement importantly demonstrate features trained natural images specific extract structure features infrared images hence feasible handle tasks using trained features directly elsevier rights reserved
demonstrate notion family constitution self enforcing renegotiation proof norm requiring adults provide attention elderly parents carries world identical individuals reproduce asexually one individuals differentiated sex preferences marry children bargain allocation domestic resources heterogenous world couples sorted preferences couple common preferences satisfy certain condition couple interest instilling preferences children policies generally nonneutral particular wage redistribution may raise compulsory education reduce share adult population governed family constitutions thus share elderly population receive attention children
assess intra inter observer agreement morphological evaluation mandibular cortical bone panoramic radiographs examine factors affecting diagnosis determine causes diagnostic discrepancy three experienced observers evaluated mandibular cortical shape panoramic radiographs females divided images three classes intra inter observer agreements calculated effect mandibular cortical width shape classification examined causes diagnostic discrepancy investigated overall intra inter observer kappa values diagnosing mandibular cortical shape respectively kappa values diagnosing class low radiographs diagnosed class class ranges mandibular cortical width overlapped discrepancies diagnosis caused slight resorption endosteal margin cortical bone endosteal cortical residues near thinned smooth cortex superimposition hyoid bone mandible inter observer agreement evaluating mandibular cortical shape moderate substantial diagnostic discrepancies mainly caused differences evaluation endosteum near cortical bone
background aim hepatocellular cancer hcc sixth common cancer liver fibrosis strongly associated hcc treatment options limited preventive strategies developed important step beginning liver fibrosis strong inflammatory response last recognized member serotonin receptor family expressed central nerve system peripheral system lot functions like learning memory smooth muscular relaxation control circadian rhythms thermoregulation pain migraine schizophrenia anxiety cognitive disturbances even inflammation methods therefore examined biochemical histopathological molecular effects receptor agonist antagonist inflammatory liver fibrogenesis animal models progressive cirrhosis mouse model induced carbon tetrachloride ccl hepb cells results expression observed liver vivo vitro ccl induced damage receptor agonist antagonist reduced liver markers mice hepb cells carbon tetrachloride ccl induced damage agonist antagonist protected liver tissue oxidative stress fibrosis agonist antagonist induces anti inflammatory anti fibrinotic anti cytokine features liver fibrosis vivo vitro conclusions receptors modulatory function coming pharmacological target inflammatory fibrotic process receptor agonist showed significant hepatoprotective effects liver fibrosis might become useful therapeutic target chronic liver inflammation fibrosis elsevier rights reserved
voters tend misattribute issue positions political candidates consistent partisan affiliation even though candidates never explicitly stated endorsed stances prevailing explanation political science voters misattribute candidates issue positions use political knowledge make educated incorrect guesses suggest voter errors also stem different source false memories current study examined event related potential erp responses misattributed accurately remembered candidate issue information report erp responses misattributed information elicit memory signals similar correctly remembered old information pattern consistent false memory rather educated guessing interpretation misattributions results suggest types voter misinformation candidates may harder correct previously thought
although known parents adolescents hold different views regarding adolescent characteristics inter rater agreement adolescent behaviors parents adolescents low know little parent adolescent dis agreement perceptions parenting current study used parent adolescent dyads age years female address gap examined discrepancy parents adolescents perceptions parent negative reactions toward adolescent anger affects adolescent problem behaviors results suggested direction disagreement two parties important adolescents viewed parenting negatively parents adolescents showed elevated levels broadband externalizing behaviors specifically aggressive behaviors finding suggests importance adolescents subjective views mothers fathers react findings discussed terms methodology family studies implications toward future research
wind energy characterized fluctuation main intermittent source damage stability electrical network leads imbalance production consumption resolve difficulty integration micro grid based wind farm interconnected electricity grid proposed presents first objective paper two level inverter much used domain main limitations solutions fact voltage output presents high ripples inverter practical solution applications high power thus second aim paper consists using multicellular inverter main unit farm based three permanent magnet synchronous generators entrained three aero generators unity connected bus three controlled rectifiers obtained power injected electricity grid using multicellular inverter well inductor resistor filter three generators proposed inverter controlled vector control theoretical study suggested farm parented simulated using matlab simulink environment obtained simulation results confirm approach robustness
paper dimensional jimbo miwa equation solved fan sub equation method improved algorithms result many new general travelling wave solutions obtained including kink shaped soliton solutions rational solutions triangular periodic solutions jacobi weierstrass doubly periodic wave solutions certain limit condition obtained jacobi elliptic periodic wave solutions degenerate soliton solutions shown improved algorithms fan sub equation method lead solutions external linear functions possessing two remarkable evolutionary properties wave propagation skew amplitude enlarges along increasing time
effort develop digital earth made dramatic progress terms visualisation visual data integration use cases demand semantically rich analysis provide analysis ensure legitimate representations spatial data visualisation derived necessary provide comprehensive analytical capabilities view questions aesthetic valuation landscape require richer analytical response simply whether possibly much object area land seen requires interrogation scene appears distinguish transient visual effects locally invariant view point change paper explores data structure support scene analytics first reviews existing techniques fields gis computer graphics potential limitations providing qualitatively nuanced visual analysis introduces new method encoding visually apparent relationships terrain models prototype implementation presented based quad edge triangular irregular network though believed raster vector implementation would possible although developed primarily landscape analysis mind method could wider applicability
educators researchers authors paper participated different points time national science foundation funded research program place culturally responsive education generative justice frameworks discovered mechanisms create generative contexts contexts value possibly returned community people generating value live work school school school uniform required individual attention care one think generative contexts educational preconditions generative justice aim show generative contexts crucial understanding larger theory generative justice provide three examples generative contexts first generative context school technology teacher brought community hairstylist classroom help teach computer programming cornrow braiding skill relevant african american students next generative context school student demonstrates soldering skills learned family members third school waste makerspace workshop students created garden technology designs low income communities
background purpose changes sensory information shown influence muscle function locally clinicians however believe influence may extensive investigate clinical concept subjects severe ankle sprain assessed local sensation changes proximal hip back muscle function subjects total potential subjects whose medical histories assessed men age years previously sustained severe unilateral ankle sprain matched control subjects previous lower limb injury participated study methods using experimental model tests vibration sensation ankle indicating sensation changes well surface electromyography muscle recruitment patterns hip extension indicating muscle function proximally biceps femoris gluteus maximus lumbar erector spinae muscles made sides unilaterally injured matched control subjects results significant decreases vibration perception significant delays gluteus maximus muscle recruitment hip extension found injured group conclusion discussion author concludes local sensory proximal muscle function changes associated unilateral severe ankle sprain
flexibility requirements prospective energy systems increase balance intermittent electricity generation renewable energies one option tackle problem electricity storage demand quantification often relies optimization models thermal renewable dispatch capacity expansion within tools power plant modeling typically based simplified linear programming merit order dispatch mixed integer unit commitment economic dispatch milp latter able capture techno economic characteristics large extent ramping start costs allows decision generator units simplified method superior computational effort present assessment storage expansion affected method power plant modeling apply cost minimizing optimization model comparing milp moreover evaluate influence wind photovoltaic generation shares vary granularity power plant mix within milp results show underestimates storage demand neglects technical restrictions affect operating costs leading unrealistically flexible thermal power plant dispatch contrarily storage expansion higher milp deviation approaches however becomes less pronounced share renewable generation increases elsevier ltd rights reserved
regions malaysia facing water scarcity problem nowadays despite malaysia high quantity water resources increasing water demand triggered initiatives look alternative water supply rainwater harvesting proposed government part solutions mitigate water scarcity problem literatures associated rainwater harvesting obtained various sources literatures reviewed instrumental analyze potential policies development rainwater harvesting malaysia article discusses potential rainwater harvesting malaysia dynamic climate case study challenges rainwater harvesting development terms environment policy economy social technical pointed way forward rainwater harvesting anticipated rainwater harvesting going play role alternative water resource country order promote rainwater harvesting malaysia inter ministerial multi stakeholders operations needed mainstream alternative water resource national strategy elsevier ltd rights reserved
toxoplasma gondii important opportunistic agent especially immunocompromised hosts cause significant morbidity mortality hence detection monitoring anti toxoplasma antibodies great interest hiv infected patients study prevalence toxoplasmosis associated risk factors carried among hiv infected patients jahrom southern iran prevalence anti toxoplasma igg antibodies hiv infected patients elisa pcr performed samples blood samples positively detected among hiv patients anti toxoplasma igg antibodies significantly higher age group years old seroprevalence toxoplasmosis patients cells significantly higher groups without igg antibodies count mean seropositive patients lower seronegative patients seroprevalence toxoplasmosis patients highly active antiretroviral therapy significantly less patients without therapy conclusion study showed low seroprevalence latent toxoplasmosis among hiv infected patients region confirmed need intensifying prevention efforts among high risk population also risk toxoplasmosis reactivation could important among population
aimthe use anticholinergic drugs strongly linked adverse health outcomes among older adults especially cognitive impairment dementia present study aimed evaluate cognitive decline related use anticholinergic drugs among older men living veterans homes taiwan methodsthis retrospective cohort study substudy longitudinal older veterans study total residents living four taiwan veterans homes receiving two consecutive mini mental state examinations within interval months january december enrolled present study medication lists participants reviewed physician anticholinergic properties individual medications evaluated using anticholinergic cognitive burden scale cognitive decline defined decrease mini mental state examinations scores study period resultsoverall persons exposure anticholinergic drugs baseline designated frequently used anticholinergic drugs cardiovascular drugs antipsychotics theophylline antidepressants gastrointestinal drugs antihistamines adjusting covariates participants significantly higher risk short term cognitive decline excluding participants using antipsychotics non antipsychotics participants still significantly higher risk short term cognitive decline conclusionsexposure anticholinergic drugs significantly increased risk short term cognitive decline among older men adverse effects remained similar antipsychotics excluded analysis intervention study required evaluate whether reducing anticholinergic burden might improve cognitive function among older adults geriatr gerontol int suppl
paper two techniques based learning action dependent heuristic dynamic programming adhdp demonstrated demand side management domestic electric water heaters dewhs problem modeled dynamic programming problem state space defined temperature output water instantaneous hot water consumption rate estimated grid load according simulation learning adhdp reduce cost energy consumed dewhs approximately respectively simulation results also indicate techniques minimize energy consumed load peak periods result customers saved annually using learning adhdp techniques control dewhs gallons tank size operation better cost reduction resulted using state art control technique simulation parameters best authors knowledge first work uses approximate dynamic programming techniques solve dewh load management problem
distributed leadership explored internationally leadership model promote advance excellence learning teaching higher education paper presents assessment effectively distributed leadership enabled five australian institutions implementing collaborative teaching quality development scheme called peer assisted teaching scheme scheme brings together expertise teams academics coordinators institutional learning teaching portfolio holders shared goal enhancing learning teaching quality distributed leadership benchmarking tool used assess scheme effectiveness found scheme highly consistent distributed leadership benchmarks benchmarking tool easily used assessing alignment otherwise teaching learning quality initiatives distributed leadership benchmarks paper interest seeking assess implementations distributed leadership improve teaching quality leadership capacity
purpose review discovery new class intrinsically photosensitive retinal ganglion cells iprgcs revealed superior role various nonvisual biological functions including pupil light reflex circadian photoentrainment recent findings recent works identified characterized several anatomically functionally distinct iprgc subtypes added strong new evidence accessory role iprgcs visual system humans summary review summarizes current concepts related iprgc morphology central connections behavioural functions highlights recent studies clinical relevance iprgcs clinical implications melanopsin system widespread particularly related chronobiology
propose multi party quantum summation protocols based single particles participants allowed compute summation inputs without help trusted third party preserve privacy inputs one participant generates source particles needs perform unitary operations single particles needed beginning protocols
sexual health people mental illness commonly overlooked neglected inadequately addressed mental health care despite evidence showing people severe mental illness vulnerable sexually transmitted infections including hiv sexual side effects sexual dysfunction general population article reports study investigated sexual health screening five community mental health clinics within large regional health service victoria australia aim study examine extent sexual health screening currently undertaken newly admitted case managed consumers identify types screening undertaken exploratory design using retrospective file audit used study total medical records met study inclusion criteria study found less consumers provided sexual health screening first weeks case management study also found sexual side effects issues fertility sexual self esteem safe sexual practices sexual dysfunction rarely screened poor sexual health screening implications safety quality mental health care requires targeted research improve understandings approaches care
aim aim study determine injury rates men varsity ice hockey team six years data ice hockey injury rates profile continue increase hope assisting injury prevention methods university british columbia men varsity team followed prospectively six year period student athletes completed preseason medical examinations physiological assessments team physician evaluated injury team therapist completed injury report forms attendance records player results total player exposures recorded combined injury rate injuries player game practice exposures statistically significantly higher risk injury observed games greatest risk injury observed second period forwards sustained greater percentage injuries compared defensemen goalies sprains strains accounted injuries followed concussions non contact injuries common anatomy sustaining injuries head neck face region high percent age recorded injuries required less seven days return full activity conclusion risk injury university ice hockey players greater games dependant playing position players prone sprains strains may involve contact concussion knee joint injury rates continue cause concern
clinical practice guidelines management constipation adults aim generate recommendations optimal approach chronic constipation primary care specialized outpatient setting main objective provide healthcare professionals care patients chronic constipation tool allows make best decisions prevention diagnosis treatment condition intended family physicians primary care specialist nurses gastroenterologists health professionals involved treatment patients well patients guidelines developed response high prevalence chronic constipation impact patient quality life recent advances pharmacological management grading recommendations assessment development evaluation working group grade system used classify scientific evidence strengthen recommendations elsevier espana aeeh aeg rights reserved
intradetrusor onabotulinumtoxina therapy proven effective decreasing episodes urgency urinary incontinence improving quality life patients refractory idiopathic neurogenic detrusor overactivity definition reporting urinary tract infections well dosing onabotulinumtoxin varied across trials demonstrated increased risk developing urinary tract infection onabotulinumtoxina injections compared placebo injection occurrence urinary tract infections found persist multiple treatment cycles rates catheterization seem decrease subsequent treatments multiple theories exist current literature able elucidate mechanism intradetrusor onabotulinumtoxina injections increase risk urinary tract infections
mirabegron relatively new drug introduced treat overactive bladder syndrome used either part combination drug extensively studied good number phase phase iii trials showing promising outcomes studies show mirabegron effective well tolerated drug could adverse effects concern review look trials mirabegron well pharmacokinetics mechanism action side effects documented literature
excessive unfolded proteins accumulation endoplasmic reticulum cause stress evolved involve various metabolic diseases particular stress plays important role pathogenesis diabetes stress course diabetes accompany oxidative stress production reactive oxygen species ros among superoxide anion center dot first produced ros recognized cell signaling mediator involved physiological pathological process diabetes hence development effective monitoring methods center dot live cells vivo great importance ascertaining onset progress related diseases herein new endoplasmic reticulum targeted two photon fluorescent probe termed bzt designed synthesized imaging center dot probe bzt shows high sensitivity selectivity stability low cytotoxicity based superior properties rise center dot levels endoplasmic reticulum induced different stimuli visualized one two photon fluorescence imaging importantly utilizing bzt two photon fluorescence imaging results demonstrate endogenous center dot concentration abdominal hepatic tissue diabetic mice higher normal mice meanwhile treated metformin broad spectrum antidiabetic drug diabetic mice exhibit depressed center dot level proposed two photon probe bzt might serve perfect tool image center dot fluctuations study relevance various diseases live cells vivo
study showed bisphosphonate safe effective treatment bone disorders stage chronic kidney disease ckd rats intermittent teriparatide therapy showed anabolic action bone even secondary hyperparathyroidism conditions without adverse effect mineral metabolism late stage ckd patients late stage ckd high risk fragility fractures however consensus efficacy safety osteoporosis medications patients late stage ckd present study aimed examine efficacy safety alendronate aln teriparatide tpd treating bone disorder late stage ckd pre existing secondary hyperparathyroidism using rat model ckd male week old sprague dawley rats subjected nephrectomy sham surgery randomized following four groups sham vehicle saline subcutaneous daily aln daily tpd daily medications commenced weeks age continued weeks micro computed tomography histological analysis infrared spectroscopic imaging serum assays performed nephrectomized rats developed hyperphosphatemia secondary hyperparathyroidism shpt high creatinine equivalent ckd stage humans aln suppressed bone turnover increased degree mineralization cortical bone resulting improvement mechanical properties tpd increased bone turnover significantly increased degree mineralization micro geometry bone volume resulting significant improvement mechanical properties aln tpd adverse effect renal function mineral metabolism safe effective treatment bone disorders stage ckd rats intermittent tpd therapy showed anabolic action bone even shpt conditions without adverse effect mineral metabolism late stage ckd
melanopsin containing intrinsically photosensitive retinal ganglion cells iprgcs class photoreceptors established roles non image forming processes contributions image forming vision may include estimation brightness animal models central understanding physiological mechanisms iprgc function evidence conservation function across species intrinsically photosensitive retinal ganglion cells divided five ganglion cell subtypes show morphological functional diversity research humans established iprgcs signal environmental irradiance entrain central body clock solar day regulating circadian processes sleep addition iprgcs mediate pupil light reflex plr making plr readily accessible behavioral marker iprgc activity less known iprgc function retinal optic nerve disease emerging research providing insight function diabetes retinitis pigmentosa glaucoma hereditary optic neuropathy briefly review anatomical distributions projections basic physiological mechanisms iprgcs proposed known functions animals humans without eye disease introduce paradigm differentiating inner outer retinal inputs pupillary control pathway retinal disease apply paradigm patients age related macular degeneration amd cases patients amd provide initial evidence iprgc function altered dysfunction pronounced advanced disease perspective refined pupillometry paradigms plr extended amd assessment tool measurement inner outer retinal dysfunction
paper means similarity transformations study exact analytical solutions generalized nonlinear schrodinger equation variable coefficients equation appears literature describing evolution coherent light nonlinear kerr medium bose einstein condensates phenomena high intensity pulse propagation optical fibers restricting coefficients satisfy ermakov riccati systems multiparameter solutions present conditions existence explicit solutions singularities family oscillating periodic soliton type solutions also show existence bright dark peregrine type soliton solutions means computer algebra system exemplify nontrivial dynamics solitary wave center solutions produced multiparameter approach elsevier inc rights reserved
past two decades government efforts provide water access rural communities brazil semiarid northeast region focused building systems capture store rainwater importantly one million cisterns program pmc article presents analytic model based daily precipitation data evaluate sustainability rainwater capture application model analysis ofthe pmc reveals heterogeneous climate region causes large spatial variability effectiveness program addition size area capture run coefficient roofs amount offirst flush diversion also important effects analysis demonstrates rainwater capture offer sufficient water drinking stand alone solution meet pmc objectives guaranteeing sustainable universal access water drinking cooking basic hygiene regions years
paper studies treatment jute geotextile isothiazolinone fluorocarbon derivatives impart antimicrobial water repellent property reported improved end use specific performance observed treated jute geotextile possesses higher durability water well soil water ambience
effect mindfulness meditation false memory susceptibility examined three experiments mindfulness meditation encourages judgment free thoughts feelings predicted participants mindfulness condition would especially likely form false memories two experiments participants randomly assigned either mindfulness induction instructed focus attention breathing mind wandering induction instructed think whatever came mind overall number words deese roediger mcdermott paradigm correctly recalled differ conditions however participants mindfulness condition significantly likely report critical nonstudied items participants control condition third experiment tested recognition used reality monitoring paradigm participants reduced reality monitoring accuracy completing mindfulness induction results demonstrate potential unintended consequence mindfulness meditation memories become less reliable
biodiversity mapping african savannah important monitoring changes ensuring sustainable use ecosystem resources biodiversity mapping benefit multi spectral instruments worldview high spatial resolution spectral configuration encompassing important spectral regions previously available vegetation mapping study investigated benefits eight band worldview spectral configuration discriminating tree species southern african savannah multiple images acquired key points typical phenological development savannahs peak productivity transition senescence improve tree species classifications first assessed discriminatory power bands using interspecies spectral angle mapper sam via band add procedure tested spectral capability worldview simulated ikonos tree species classification results interspecies sam procedure identified yellow red bands statistically significant bands respectively discriminatory power transition wet dry season april using random forest classifier classification scenarios investigated showed bands sensor achieved higher classification accuracy april date transition wet dry season senescence compared march date peak productivity season spectral configuration systematically outperformed ikonos sensor spectral configuration iii multi temporal approach march april combined improved discrimination tress species produced highest overall accuracy results consistent interspecies sam procedure yellow band also showed statistically significant contribution improved classification accuracy results highlight mapping opportunities presented data monitoring distribution status species often harvested local communities sclerocharya birrea encroaching species species specific tree losses induced elephants elsevier rights reserved
one main challenges working modern climate model ensembles increasingly larger size data produced consequent difficulty storing large amounts spatio temporally resolved information many compression algorithms used mitigate problem since designed compress generic scientific datasets account nature climate model output compress individual simulations work propose different statistics based approach explicitly accounts space time dependence data annual global three dimensional temperature fields initial condition ensemble set estimated parameters small compared data size regarded summary essential structure ensemble output therefore used instantaneously reproduce temperature fields ensemble substantial saving storage time statistical model exploits gridded geometry data parallelization across processors therefore computationally convenient allows fit nontrivial model dataset billion data points covariance matrix comprising entries supplementary materials article available online
constrained output feedback model predictive control approach nonlinear systems presented paper state variables observed using unscented kalman filter offers advantages extended kalman filter nonlinear dynamic model system considered investigation developed considering possible effective elements model adaptively linearized along prediction horizon using state dependent state space representation order improve performance control system many linearized models number prediction horizons obtained sample time optimum results previous sample time utilized linearization current sample time subsequently linear quadratic objective function constraints formulated using developed governing equations plant performance effectiveness proposed control approach validated simulation real time experimentation using constrained highly nonlinear aerodynamic test rig twin rotor mimo system trms elsevier ltd rights reserved
problem stimulation nerve growth factors focused transcranial extracorporeal shock waves tesw persons within unresponsive wakefulness syndrome apallic syndrome made effective patients methods five patients apallic syndrome differing severity received years accident average week physicomedical complex treatment series including focused extracorporeal shock waves device duolith storz medical spastic muscles enhancement vigilance could seen complex therapies augmented transcranial focused extracorporal shock waves tesw years patients received average tesw treatment series patients tested german coma remission scale crs german scale expressive communication self actualisation seks ziegler results patients improved abilities crs seks three peg feeding tubes could removed nonverbal communication initiated times discussion possible mode actions relation non invasive methods brain stimulation discussed conclusion tesw seem stimulate vigilance motoric patients apallic syndrome possible placebo effect neurophysiological must verified
interest high speed electrical machines automotive applications increased recently includes electrically assisted turbochargers eat air compressors fuel cells waste heat recovery whr generators kinds application working elevated temperature environments losses machine power electronics carefully analyzed context paper presents coupled electronic magnetic simulation application high power high speed motor coupling two models mainly linked phase currents impact electronic driver addition motor performances must considered optimize overall system efficiency however optimizations electronic driver electric motor time consuming since based finite element methods magnetic simulations kirchhoff equations resolution electronic simulations therefore paper presents fast coupled model increase computation speed application optimize system using high power high speed motor special focuses motor rotor losses overall efficiency
objective aim investigate association prenatal sex hormone exposure dementia diagnosis background evidence indicates relatively low testosterone levels risk factor men develop alzheimer disease research examined current rather premorbid testosterone levels little research addressed testosterone women methods men women diagnosed controls estimated prenatal exposure testosterone estrogen using ratio length second fourth digit analyzed data using men versus women controls versus participants analysis variance results men significantly higher ratios male controls indicating lower levels prenatal testosterone higher levels prenatal estrogen exposure women significantly lower ratios female controls indicating higher levels prenatal testosterone lower levels prenatal estrogen exposure conclusions findings suggest lower levels prenatal testosterone higher levels estrogen exposure risk factor men higher levels prenatal testosterone lower levels prenatal estrogen exposure risk factor women risk may related prenatal exposure sex hormone different individual chromosomal sex
linear tubular asynchronous generator used generator driven seawave presented design criteria tlim hollowed iron induced part well technological processes adopted materials utilized various parts described methodologies mechanical assembling electric wiring considered finally prototype bimetallic induced part designed built presented experimental results electrical mechanical variables shown
exploratory research performed promising safety intervention concept prevention design ptd also known designing construction safety dfcs overall research goal increase understanding role owners constructed facilities play adopting ptd capital projects total face face interviews anonymous surveys completed four case study organizations addition surveys completed online members national construction associations organizations industry survey data indicate majority owner firm employees heard ptd find concept compelling anticipate significant barriers implementation key empirical findings indicate explicit ptd process required implementation proactive owner leadership involvement necessary initiate ptd project owner leadership required set high expectations worker safety health ensure general contractor trade contractor personnel participation design review process supporting tools design checklists four dimensional computer aided design cad systems risk identification assessment documents facilitate ptd process findings used owners effectively implement ptd program one projects american society civil engineers
smart meters cornerstone new conception electrical network smart grid providing detailed information users energy consumption allowing suppliers remotely collect data billing nevertheless features useful energy suppliers also play big role control microgrid since recorded power energy profiles integrated energy management systems ems addition basic power quality disturbances detected reported advanced metering systems thus paper expose example smart meters integration microgrid scenario intelligent microgrid lab aalborg univeristy aau first installation available microgrid lab introduced three different test scenarios respective results presented regarding capabilities system advantages integrating smart meters information microgrid control
background fifty years inception cardiac intensive care unit cicu noncardiovascular illnesses become prevalent may contribute morbidity mortality objectives authors performed multivariate statistical analyses determine association acute noncardiovascular illnesses outcomes including length stay los mortality hospital readmission methods studied admissions october november cicu university virginia health system tertiary care academic medical center systematic inspection individual charts identified primary secondary diagnoses vital sign measurements length stay los hospital readmissions mortality results common primary diagnosis acute coronary syndrome consisted non segment elevation acute coronary syndrome segment elevation myocardial infarction sepsis frequent noncardiovascular primary diagnosis occurred admissions acute kidney injury acute respiratory failure occurred admissions one half admissions marked acute respiratory failure acute kidney injury sepsis median los cicu hospital days interquartile range iqr days days iqr days mortality cicu hospital patients survived hospital discharge readmitted within days sepsis acute kidney injury acute respiratory failure associated mortality acute kidney injury acute respiratory failure new onset subclinical atrial fibrillation occurred admissions associated cicu los conclusions many patients modern cicu acute noncardiovascular illnesses associated mortality increased los american college cardiology foundation
exergy analysis based first second thermodynamic laws significant tool assess energy systems study energy exergy analyses compression ignition internal combustion engine operating sunflower methyl ethyl ester blends diesel fuel investigated results presented first second law efficiency effective work exergy destruction values different engine speeds concluded ethyl ester blends appropriate fuels engine terms performance
paucity research psychopathy relates decision making study assessed relationship affective decision making psychopathic personality sample prisoners characterized terms psychopathic traits using psychopathic checklist screening version pcl decision making assessed using iowa gambling task igt higher levels psychopathy related advantageous choices also counter intuitively higher levels antisocial traits facet predicted advantageous choices learning phase task findings suggest psychopathic facets may relevant decision making risk highlight importance investigations considering facet trait level relationships decision making
purpose population pharmacometric modeling variety mathematic algorithms implemented major modeling software packages facilitate maximum likelihood modeling foce laplace methods designed estimate set parameters maximize joint likelihood observations given problem foce still currently widely used method population modeling methods getting popular current generation methods choice robustness complex models sparse data structures several versions method implementation available public modeling software packages although several studies reviews comparing performance different methods handling relatively simple models dedicated study compare different versions algorithms solving complex pbpk models study took everolimus model drug simulated data based published results three popular methods saem imp qrpem foce benchmark reference evaluated estimation accuracy converging speed solving models increased complexity sparse rich sampling data structure tested concluded foce superior methods simple structured models complex models sparse data methods much robust estimation accuracy close across methods general ranking speed fastest slowest qrpem imp saem imp gave realistic estimation parameter standard errors estimation standard errors observed saem qrpem methods
paper deals qualification structured light scanning system application reverse engineering mechanical part white light scanner electro optical device based principle optical triangulation measurement accuracy affected measured part geometry position within scanning window effects scan depth projected angle characterizing surface normal measured surface scanning point view measurement accuracy considered standard calibration process manufacturers identified experiments present work digitization errors analyzed characterized thanks measurement protocol based quality indicators theses quality indicators evaluated thanks simple calibrated artifacts aim work redefine ideal relative distance relative angle minimizing digitizing errors relation stated manufacturer reverse engineering application
million hearts initiative goal preventing million heart attacks strokes leading causes mortality several public health healthcare strategies american heart association american college cardiology support program cardiovascular risk reduction model developed million hearts center medicare medicaid services strategy assess value based payment approach toward reduction year predicted risk atherosclerotic cardiovascular disease ascvd implementing cardiovascular preventive strategies manage abcs aspirin therapy appropriate patients blood pressure control cholesterol management smoking cessation purpose special report describe development intended use million hearts longitudinal ascvd risk assessment tool million hearts tool reinforces builds acc aha guideline assessment cardiovascular risk allowing clinicians estimate baseline updated year ascvd risk estimates primary prevention patients adhering appropriate abcs time alone combination tool provides updated risk estimates based evidence high quality systematic reviews meta analyses abcs therapies novel approach personalized estimation benefits risk reducing therapies primary prevention may help target therapies provide greatest benefit serves basis center medicare medicaid services program designed evaluate million hearts cardiovascular risk reduction model
background mir promote apoptosis inhibit proliferation invasion metastasis breast cancer cells however mechanisms fully understood therefore comprehensive analysis target genes pathways networks mir necessary material methods mir profiles patients cancer genome atlas tcga analyzed gene expression profiling gse mir transfected mcf cells scramble control cells downloaded gene expression omnibus geo differentially expressed genes degs identified potential genes targeted mir also predicted gene ontology pathway network analyses constructed degs predicted genes results tcga data low level mir expression might represent diagnostic auc marker mir prognostic marker mir linked estrogen receptor progesterone receptor human epidermal growth factor receptor mir associated tumor lymph node metastasis stages moreover genes selected degs geo potential target genes prediction databases genes related transcription metabolism biosynthesis proliferation results also significantly enriched vegf mtor focal adhesion wnt chemokine signaling pathways conclusions mir mir may prospective biomarkers prognosis diagnosis respectively associated diverse clinical parameters target genes mir regulate development progression results provide insight pathogenic mechanism potential therapies
composites magnetic particles polymeric matrices received increasing research interest due capacity respond external magnetic electromagnetic fields study agar gelidium robustum chosen natural biocompatible polymer build matrix magnetic carbonyl iron particles cip uses biomedical fields heat transfer behavior cip agar composites containing different concentrations magnetically aligned non aligned cip agar matrix studied using photothermal radiometry ptr back propagation emission configuration morphology cip agar composites aligned nonaligned cip magnetic field also evaluated scanning electron microscopy sem results revealed dominant effect cip concentration alignment patterns induced magnetic field agrees behavior thermal diffusivity thermal conductivity agar served perfect matrix used cip cip agar composites magnetically aligned cip concentration considered promising smart material hyperthermia treatments biomedical field elsevier ltd rights reserved
time sampling methodology implemented examine prospective associations affect desire gamble gambling behavior individuals diagnosed mood disorder thirty male female adults lifetime diagnosis depressive bipolar disorder diagnosis endorsed current gambling lifetime gambling harm participated present study participants completed electronic diary entries current affective state desire gamble gambling behavior consecutive days hierarchical linear modelling revealed affect predictor gambling behavior instead affect predicted desire gamble high levels sadness arousal independently predicting increased desire gamble desire gamble predicted actual gambling behavior differences across diagnostic groups terms gambling motivations baseline however day period participants bipolar disorder endorsed gambling cope negative affect often participants depressive disorder whereas depressive disorder often endorsed gambling social reasons enhancement positive affect present findings provide evidence negative affect directly related actual gambling behavior suggest affective states rather impact desire gamble
study investigated whether may useful treating rheumatoid arthritis two collagen induced arthritis cia experiments showed therapeutic preventive treatment reduced severity joint inflammation cia third cia experiment indicated compared vehicle treatment therapeutic treatment associated significantly smaller area curve overall clinical joint score day observation period treatment also associated lower day serum levels histological joint scores moreover splenocytes harvested treated mice exhibited lower basal collagen stimulated production ifn gamma days splenocytes vehicle treated mice fourth fifth experiments indicated earlier treatment resulted better response addition human thp murine raw macrophages fibroblast like synoviocytes fls patients used vitro analyses treatment lipopolysaccharide stimulated macrophages derived thp raw monocytes significantly reduced tnf alpha secretion thp raw however treatment affect expression tnf alpha stimulated fls reduced clinical joint scores serum levels histological joint scores mice cia addition lowered collagen stimulated ifn gamma production murine cells reduced tnf production macrophages vitro thus may ameliorate joint inflammation modifying cell reactions triggering autoantigen reducing macrophage cytokine production author published elsevier
objectiveto describe two patients recurring unilateral brief headaches fulfilled criteria primary cough headache chronic paroxysmal hemicrania cph backgroundch typically bilateral headache specifically triggered cough straining valsalva maneuvers report cases sharing features primary headache disorders cph suggest common pathogenic mechanisms methodscase reports resultstwo patients one man aged two year history daily unilateral side locked headache attacks lasting minutes associated ipsilateral tearing headaches triggered cough sneezing laughing bending forward patients experienced marked sustained improvement indomethacin relapsed interrupted conclusionsthese cases suggest existence transitional phenotypes shared pathogenic mechanisms cph two indomethacin responsive headaches comprehensive analysis different subtypes necessary understand relation primary headaches
phosphorylated fullerene sulfonated polyvinyl alcohol pfsp cation exchange membrane prepared characterized applications studied microbial fuel cell mfc copper removal along power generation phosphorylation fullerene confirmed fourier transform infrared spectroscopy ftir composite membrane prepared solution casting method characterized ftir scanning electron microscopy sem thermo gravimetric analysis tga methods proton conductivity water uptake ion exchange capacity iec prepared membrane observed meq respectively open circuit voltage ocv power density obtained respectively composite membrane maximum removal compared ultrex cmi commercial membrane prepared membrane expected offer vital constructive properties application fuel cell technology remove copper ions wastewater elsevier rights reserved
introduction functional gastrointestinal disorders fgids common children ages comprise wide range conditions related gastrointestinal tract attributed structural biochemical abnormalities fgids diagnosed according symptom based rome criteria areas covered revised pediatric rome criteria published revised criteria discussed review article youngest age group neonates toddlers criteria infant colic undergone notable revisions prominent changes rome made criteria children adolescents definition two new fgids functional nausea functional vomiting restructuring criteria functional abdominal pain disorders including definition fgid subtypes functional dyspepsia irritable bowel syndrome expert commentary overall rome refined expected improve process diagnosing fgids pediatric population better facilitate healthcare professional distinguishing different clinical entities changes likely benefit future research clinical care
mood disorders multifactorial heterogeneous diseases caused interplay several genetic environmental factors humans mood disorders often accompanied abnormalities organization circadian system normally synchronizes activities functions cells tissues studies animal models suggest basic circadian clock mechanism runs essentially cells implicated modulation biological phenomena regulating affective behaviors particular recent findings highlight importance circadian clock mechanisms neurological pathways involved mood monoaminergic neurotransmission hypothalamus pituitary adrenal axis regulation suprachiasmatic nucleus olfactory bulb activities neurogenesis defects level circadian clock mechanism system may contribute etiology mood disorders modification circadian system using chronotherapy appears effective treatment mood disorders additionally understanding role circadian clock mechanisms affect regulation different mood pathways open possibility targeted pharmacological treatments
concurrent hash tables one important concurrent data structures numerous applications since hash table accesses dominate execution time overall application need implementations achieve good speedup unfortunately currently available concurrent hashing libraries turn far away requirement particular contention elements occurs starting point better performing data structures fast simple lock free concurrent hash table based linear probing limited word sized key value types support dynamic size adaptation explain lift limitations provably scalable way demonstrate dynamic growing performance overhead comparable generalization sequential hash tables perform extensive experiments comparing performance implementations six widely used concurrent hash tables considerably faster best algorithms similar restrictions order magnitude faster best general tables extreme cases difference even approaches four orders magnitude
objective develop validate subjective measure cognitive fatigue state trait inventory cognitive fatigue community dwelling older adults design scale development test construction setting community dwelling older adults enrolled longitudinal cohort aging study participants participants healthy english speaking community dwelling adults age years interventions applicable main outcome measures state trait inventory cognitive fatigue total cognitive fatigue motivation mental effort boredom summation scores state trait forms results principal component analysis yielded expected components state trait forms cognitive fatigue mental effort motivation boredom components good reliability good convergent validity measured strong positive relation cognitive fatigue subjective measure general fatigue even controlling depressive symptoms greater subjective cognitive fatigue associated worse performance measures thought sensitive aspects executive functioning conclusions study developed established psychometric properties new instrument subjective measurement cognitive fatigue use community dwelling older adults state trait inventory cognitive fatigue relatively brief administration time min mean strong psychometric properties support utility research clinical settings future studies establish psychometric properties scale populations examine predictive utility relevant clinical outcomes american congress rehabilitation medicine
lymphocytic esophagitis lye recently described clinicopathological condition little known features clinical associations aim study characterize patients lye compare non lye controls identify risk factors conducted retrospective study patients aeyen years old underwent upper endoscopy esophageal biopsy january june archived pathology slides reviewed lye diagnosed lymphocyte predominant esophageal inflammation eosinophils granulocytes three non lye controls groups also defined reflux eosinophilic esophagitis eoe normal clinical data extracted electronic medical records lye cases compared non lye controls twenty seven adults diagnosed lye majority female common symptom dysphagia fifty two percentage prior current diagnosis reflux endoscopic findings included strictures erosive esophagitis rings hiatal hernia patients required dilation histology review lye patients found lymphs hpf comparison normal reflux eoe controls patients lye tended nonwhite commonly tobacco users less likely seasonal allergies lye commonly presents dysphagia due esophageal strictures require dilation smoking associated lye whereas atopy lye considered diagnostic possibility patients characteristics undergoing upper endoscopy
current pharmacological approach alzheimer disease treatment mostly based acetylcholinesterase inhibitors acheis revisited especially terms temporal frames potential benefits noncanonic actions raising question whether inhibitors ache might also act disease modifying manner besides last decades pharmacophoric moieties known acheis covalently linked pharmacophores pursuit multitarget hybrid molecules expected induce long lasting amelioration impaired neurotransmission clinical symptoms also exert disease modifying effects research consortium synthesized defined pharmacological profile new acheis derivatives potential interest treatment among huprines derivatives characterized successfully huprine reversible ache inhibitor designed molecular hybridization tacrine huperzine shown affect amyloidogenic process vitro related neuropathology vivo mice models disease recently shown group donepezil huprine heterodimers exerts highly potent selective inhibitory action ache vitro vivo simultaneously interacting peripheral catalytic binding sites inhibiting beta amyloid aggregation whereas levetiracetam huprine hybrids shown reduce epileptiform activity neuroinflammation amyloid burden animal model summarize behavioural correlates noncanonic actions assessed three distinct biological scenarios middle age cognitive deficits associated ageing like phenotype mice besides improvement hallmark cognitive symptomatology without inducing side effects drugs shown able modulate emotional anxiety like behaviours reduce spontaneous seizures related called behavioural psychological symptoms dementia overall studies show novel multitarget anticholinesterasics exert noncanonic actions providing symptomatic disease modifying benefits potential interest management wolters kluwer health inc rights reserved
excellent properties heavy tungsten based alloys based combination hardness grains well toughness ductility binder low melting temperature usually containing nickel iron copper topology resulting properties binder network controlled complete incomplete wetting grain boundaries gbs triple junctions observed first time pseudoincomplete pseudopartial frustrated complete wetting layers also present alloys namely channel rich solid solution forms non zero dihedral contact angle dry gbs incomplete wetting also gbs containing uniformly thin rich layer pseudoincomplete wetting elsevier rights reserved
though people positions power many advantages sustain power stories abound individuals fall lofty perch happen current research examined role illusions alliance define overestimating strength one alliances others tested whether powerholders lose power possess overly positive perceptions relationships others turn leads weakening relationships studies found powerful individuals likely hold illusions alliance using laboratory well field contexts studies found individual power held illusions alliance obtained fewer resources excluded frequently alliances lost power findings suggest power sometimes leads demise powerful individuals erroneously assume others feel allied elsevier inc rights reserved
transient receptor potential melastatin trpm activated innocuous cold chemical substances antagonists channel considered effective pain urinary diseases aminopropy methylphenyemethyl oxy thienylmethyl benzamide hydrochloride amtb trpm antagonist proposed effective overactive bladder painful bladder syndrome however potential risk low blood pressure report herein synthesis structure activity relationships novel phenylglycine derivatives led identification kpr trpm selective antagonist kpr reduced number icilin induced wet dog shakes rhythmic bladder contraction rats negative cardiovascular effects effective dose elsevier ltd rights reserved
computer systems become complicated monitoring dataflows system becomes important maintaining performance however conventional methods dataflow monitoring either fine grained coarse grained difficult analyze application specific performance metrics paper propose dataflow logger suitable granularity performance analysis logger implemented java library tracks two types dataflows dataflows objects inside java program dataflows java object row column relational database way logger produce dataflow logs rich semantics application data model conduct experiment example system demonstrate obtain dataflow logs useful performance analysis also conduct detailed overhead analysis logger although logger slows example system times figure major sources overhead argue possible solutions overhead
herein study hydrodynamic modelling pontoon bridges presented bergsoysund bridge representative example model relies finite element method linearized potential theory primary emphasis placed stochastic response analysis within framework power spectral density method quadratic eigenvalue problem solved using state space representation iterative algorithm contribution fluid structure interaction overall modal damping investigated response effects due changes sea state studied frequency independent approximation hydrodynamic coefficients presented discussed elsevier ltd rights reserved
immigrants east asia make total number immigrants canada families face many challenges acculturate north america sadly children may risk sexual abuse article outline ways east asian children compared western nonimmigrant children particular disadvantage considering prosecution perpetrate abuse focus specifically areas concern cultural differences shape children memory recall cultural differences impact path disclosure sexual abuse language differences reduce chances perpetrators prosecuted sexual abuse consequences east asian immigrant youth allege suspected victims abuse serious east asian children face uphill battle see justice sexual abuse cases thus significant portion immigrant children see abusers punished worse knowledge prosecution unlikely may make east asian immigrant children vulnerable
objective study relationship level thyroid hormones clinical autonomic structural functional characteristics heart affections activity immune inflammation markers endothelial dysfunction means cognitive modeling methods patients coronary heart disease concomitant hypothyroidism examined average level tsh average level pmol average age patients years among men women complex clinical examination including clinical biochemical immune enzyme instrumental methods examination correlation regression analysis data carried results correlation analysis showed patients coronary heart disease comorbid hypothyroidism reduction left ventricular ejection fraction mostly associated increasing levels neopterin tumor necrosis factor alpha respectively condition myocardial stiffness correlated concentration reactive protein level total cholesterol concentration neopterin plasminogen activator inhibitor pai heart rate variability parameters indicators myocardial ischemic changes correlated level neopterin endothelin value correlation concentration neopterin pai left ventricular myocardium mass index lvmi early late diastolic filling velocities left ventricle ratio respectively standard deviation normal normal intervals sdnn active passive periods performed regression analysis confirmed direction relations also allowed build cognitive model clinical course ischemic heart disease patients hypothyroidism acts connecting link conclusions cognitive model developed basis correlation regression analyzes demonstrates clinical pathogenetic role immune inflammation markers endothelial dysfunction progression structural functional heart disorders ischemic autonomic changes chd patients concomitant hypothyroidism level acts connecting link
background cortical venous thrombosis cvt rare condition compared arterial stroke often occurs young individuals presenting varying clinical features aim aim study clinical profile assess outcome prognostic factors cvt patients methodology case series study done years cvt cases confirmed magnetic resonance imaging included study clinical presentation risk factors noted patients assessed time discharge physical mental status modified rankin scale used group patients accordingly scores considered good poor outcome respectively data analyzed using chi square test know association prognostic factors outcome results patients half patients age group years majority patients females common symptom headache least fever superior sagittal sinus commonly involved nearly half patients puerperal period patients aged years odds ratio confidence interval presenting symptoms fever impaired consciousness clinical signs coma papilledema focal neurological deficit statistically significant poor outcome conclusion females formed major bulk patients higher number patients showed poor outcome study showed association age headache impaired consciousness coma papilledema neurological deficit poor outcome
objective although japan non endemic area nasopharyngeal carcinoma npc proportion type npc japan different non endemic areas north america europe recently said epstein barr virus ebv also human papillomavirus hpv influence npc non endemic areas aim study clarify influence hpv npc japan methods paraffin embedded tumor specimens available patients npc diagnosed detected virus status immunohistochemistry hpv pcr situ hybridization epstein barr virus ebv encoded rna kaplan meier curves used compare overall survival viral status results among patients ebv positive hpv negative ebv positive hpv positive ebv negative hpv negative hpv positive npcs infected ebv significant differences overall survival three groups conclusion japan hpv detected patients npc suggest hpv influence npc carcinogenesis population elsevier ireland ltd rights reserved
determined levels various heavy metals water stream sediments receiving leachate runoff open air windrows msw compost plant sanandaj kurdistan iran assessed related contamination rate ecological risk determining geo accumulation index geo contamination factor ecological risk factor contamination degree pollution load index pli potential ecological risk water sediments results showed several heavy metals except concentrations higher maximum limits sediments protect aquatic life using consensus based sediment quality guidelines cbsqg reference heavy metal concentrations stream water higher canadian council ministers environment ccme limits drinking irrigation protection aquatic life except evaluation results pli indices showed stream water sediment pollution caused uncontrolled emission open air windrows composting msw elements causing pollution enriched compost values indices indicated moderate considerable ecological risk concluded source separation msw effective control runoff entering composting plant needed protect surrounding environment negative impact composting plant releases elsevier rights reserved
within paper comparative approach presented order evaluate electrical machines electrical drive trains selection machine type essential task design drive trains paper contains comparison induction machines permanent magnet synchronous machines whereas comparison follows abstract procedure since almost machine parameters given therefore assumptions made order reduce complexity machine design equations due concluding diagram becomes possible get first impression torque current characteristic machine types characteristics proved parameters commercial machines
background familial hypercholesterolaemia leads premature coronary artery diseases cad pathophysiologically measured inflammation endothelial activation oxidative stress status however status biomarkers among related unaffected relatives cases whether independent predictor biomarkers well established thus study aims compare biomarkers inflammation endothelial activation oxidative stress patients related unaffected relatives ruc normolipaemic subjects determine whether independent predictor biomarkers methods one hundred thirty one patients ruc matched recruited fasting lipid profile biomarkers inflammation hscrp endothelial activation sicam selectin oxidative stress oxidized ldl oxldl malondialdehyde mda isoprostanes isp analyzed independent predictor determined using binary logistic regression analysis results hscrp higher ruc compared mean mean sicam selectin higher compared mean respectively sicam concentration higher ruc compared mean biomarkers oxidation ldl mda isp elevated compared mean nmol independent predictor sicam ldl mda ruc independently predicted sicam conclusion screening vital biomarkers associated atherogenesis higher subjects also independently predict biomarkers endothelial activation oxidative stress furthermore despite fulfilling diagnostic criteria related unaffected family members may phenotypically express mutation may still risk developing cad reflected enhanced inflammatory endothelial activation status observed group highlights need conduct family tracing indexed cases also assess coronary risk among family members fulfil diagnostic criteria
aim study evaluate whether preparation radioactive iodine rai therapy thyroid hormone withdrawal thw low iodine diet lid risk factors development hyponatremia patients differentiated thyroid cancer thyroidectomy retrospectively reviewed medical records laboratory findings patients underwent preparation rai therapy thyroidectomy demographic clinical variables including method thyrotropin stimulation duration lid assessed serum sodium measured twice operation rai therapy hyponatremia detected patients operation patients rai therapy none patients severe hyponatremia preparation rai therapy pre rai therapy serum sodium correlated method thyrotropin stimulation twh recombinant human thyroid stimulating hormone duration lid however preparation rai therapy thw lid affect development hyponatremia logistic regression analysis preoperative serum sodium significant risk factor hyponatremia preparation rai therapy preparation rai therapy thw lid risk factor development hyponatremia patients thyroid cancer development hyponatremia neither frequent severe preparation rai therapy physicians greatly concerned rare life threatening hyponatremia preparation rai therapy
inhalation one entry ports different chemicals human body order investigate application route negative health effect humans presence volatile organic compounds vocs indoor air monitored since many years assess global trends changes distribution disposition vocs corresponding personal exposure study analyzed annual indoor air concentrations collected period years context birth control cohort study vocs additionally short time series expression model stem used identify certain correlation vocs different compound classes similar compounds tendency lower annual median indoor air concentrations found similar vocs trend higher annual median indoor air concentrations tendencies observed similar investigated compounds similar vocs applied linear regression model suitable predict global trends annual median values linearly distributed mann kendall test used confirm results linear regression model calculate trends compounds linear regression found unsuitable thus approximately four investigated vocs prediction possible using statistical approaches stem analysis revealed connection benzene ethylbenzene xylene alpha pinene carene pentadecane decamethlycyclopentasiloxane addition correlation butanol chlorobenzene heptanal ethyl hexanol concentrations
present method comparing data habitat use availability allows availability differ among observations method applicable habitats change time animals unable move throughout predetermined study area observations used maximum likelihood techniques derive index estimates probability habitat type would used equally available also demonstrate indices used compare relative use available habitats assign ranks assess statistical differences pairs indices set indices habitats compared groups animals represent different seasons sex age classes experimental treatments method allows quantitative comparisons among types affected arbitrary decisions habitats include study provide example comparing availability four categories sea ice concentration use adult female polar bears ursus maritimus whose movements monitored satellite radio tracking bering chukchi seas use ice categories bears nonrandom pattern use differed spring late summer seasons
research explored variation bond breaking effect variety bond breaking layers installed concrete pavement surface slabs lean concrete lcb base order offer parameters structure analysis pavements bond breaking layers optimize selection bond breaking layers practical road engineering projects research tested bonding stresses frictional forces slab base interface pavements different bond breaking condition well anti erosion performance base course via anti erosion tests laboratory field tests mechanical performance slab base interface treated different bond breaking layers highway projects hunan guangdong provinces bond breaking media applied research include asphalt concrete emulsified asphalt slurry seal eass geotextile emulsion wax curing agent ewca findings field tests bonding stress slab base layers indicated eass ewca better geotextile reducing friction bonding stress slab base layers findings anti erosion tests indicated conditions specimens covered geotextile far better specimens brushed asphalt surface resisting erosion specimens covered geotextile brushed asphalt far better bond breaking layer resisting erosion mechanical performance slab base interface different bond breaking media derived research offers scientific reference pavement design construction control practical road engineering projects
research emotional labour focussed front line service staff health professionals short term interactions little exists exploring emotional labour involved repeated going interactions educational leaders key stakeholders study explored relationships emotional demands three emotional labour facets burnout wellbeing job satisfaction full time school principals principals displayed significantly higher scores emotional demands work burnout job satisfaction significantly lower wellbeing scores general population structural equation modelling revealed emotional demands predicted elevated use emotional labour strategies surface acting hiding emotions inverse relationship burnout wellbeing job satisfaction surface acting faking emotions inverse relationship job satisfaction deep acting demonstrated significant associations outcome variables findings study extend current literature effects emotional labour study also extends understanding separate effects facets emotional labour aid development interventions reduce high levels burnout reported educational leaders
paper proposes digital phase leading filter current compensation plfcc technique continuous conduction mode boost power factor correction improve high line voltage light load conditions proposed technique provides corrected average inductor current reference utilizes enhanced duty ratio feed forward technique cancel adverse effect phase leading currents caused filter capacitors moreover proposed plfcc technique also provides switching dead zone nature switching loss reduced therefore proposed plfcc significantly improve power quality achieve high efficiency high line voltage light load conditions principle analysis proposed plfcc presented performance feasibility verified experimental results universal input output laboratory prototype
purpose examine influence extra physical education epe number musculoskeletal injuries public schools accounting organized sports participation osp outside school examine major injury subgroup growth related overuse gro overuse related injury group methods longitudinal controlled school based study among danish public schools baseline children participated age six schools children epe four control schools children followed weekly automated mobile phone text messages information musculoskeletal problems osp health care personnel diagnosed children according world health organization international classification diseases tenth revision data analyzed using two part zero inflated negative binomial zinb regression model results school type influence odds sustaining injury increased probability sustaining higher injury count children injuries total injuries factor confidence interval overuse factor gro factor weekly mean osp decreased odds belonging group children injuries factor total overuse gro respectively osp also increased probability sustaining higher injury count children injuries factor respectively conclusions children enrolled epe schools high osp highest odds injury high probability sustaining higher injury count compared peers schools normal special attention assigned children compulsory
paper provides overview surface waves investigation monitoring swim instrument one two payload instruments carried china france oceanography satellite cfosat planned launch date mid swim real aperture wave scatterometer operated near nadir incidence angles dedicated measurement directional spectra ocean waves swim flight model currently assembled tested performance assessed prototype data processing algorithm developed aim paper provide complete overview motivations scientific requirements mission together description design characteristics swim instrument analysis expected performances based prelaunch study end end simulator developed evaluate quality data products thus allowing overall performance instrument assessed simulations run two subsets full orbit subsets show performances instrument inversion algorithms meet scientific requirements mission
utilizing variation across state abortion restrictions minors different levels provider availability measure whether women age less careful using contraception abortions less costly terms financial opportunity cost effects abortion restrictions minors largest significant women aged younger effect restrictions decrease magnitude significance gradually women age percent state women without provider increases abortions difficult obtain women likely use pill larger percentage women provider abortions easily obtained negative effect pill usage results indicate young women forward thinking making contraceptive decisions relative direct indirect restrictions abortion access western social science association published elsevier inc rights reserved
hysteresis hinders precision smart materials sensors actuators impedes development smart material actuators paper addresses novel piecewise identification approach hysteresis smarts materials hysteresis modeled discrete preisach operator hysteresis curve divided preisach planes based monotonic changing input every preisach plane relationship input output preisach operator preisach function reached preisach function identified compare identification first order transition curves new approach new approach avoids effect wiping property preisach model new method also precise identify parameters preisach function comparison least squares method simulation experimental results based piezoceramic actuator provided illustrate proposed approach
extraintestinal disorders crohn disease common part diagnostic criteria disease varied affect joints skin eyes try identify epidemiological aspects clinical evolving series cases crohn disease series patients experienced least one extraintestinal manifestation mean age years sex ratio joint damage observed patients cases cases axial damage cases peripheral damage including cases arthritis dermatological disease observed patients cases dominated oral aphthous ulceration cases erythema nodosum cases pyoderma gangrenosum cases ocular involvement observed patients cases including two cases anterior uveitis six cases dry eye syndrome three cases redness one case episcleritis extraintestinal manifestations crohn disease fairly common variable occurring pushing period quiescence disease precede digestive symptoms joint manifestations common followed dermatological manifestations
ionic polymer metal composite ipmc new smart material sensing capability paper experimental setup characterize ipmc sensor developed corresponding sensor model constructed based neural networks similar smart materials intrinsic hysteresis nonlinearity inherent ipmc sensors case hysteresis operator introduced transform multi valued mapping hysteresis one one mapping corresponding neural model constructed neural network expanded input space order compensate nonlinearity ipmc sensor inverse model also constructed form feedforward compensator sensor finally experimental results presented validate proposed method hysteresis compensation
computer vision training model performs classification effectively highly dependent extracted features number training instances conventionally feature detection extraction performed domain expert many cases expensive employ hard find therefore image descriptors emerged automate tasks however designing image descriptor still requires domain expert intervention moreover majority machine learning algorithms require large number training examples perform well however labeled data always available easy acquire dealing large dataset dramatically slow training process paper propose novel genetic programming based method automatically synthesises descriptor using two training instances per class proposed method combines arithmetic operators evolve model takes image generates feature vector performance proposed method assessed using six datasets texture classification different degrees rotation compared seven domain expert designed descriptors results show proposed method robust rotation significantly outperformed achieved comparable performance baseline methods
state feedback method quite popular control engineering field however popular properties state feedback approach used system states obtained beforehand therefore paper proposes new observer design class uncertain systems sliding mode control theory based strictly positive real concept stability equivalent error system verified using generalized matrix inverse approach proposed switching term drive error states zero ensures global reaching condition sliding mode error system moreover presented sliding mode observer proposed possess invariance property uncertainty external disturbance furthermore developed sliding mode observer extended release limitation knowing bounds lumped perturbations advance new sliding mode observer also new adaptive sliding mode observer proposed paper finally three examples illustrated demonstrate validity proposed sliding mode observer proposed adaptive sliding mode observer copyright john wiley sons ltd
work mathematical optimization procedure used improve gas exchange process single cylinder compression ignition naturally aspirated engine duct lengths valve timing chosen optimization variables volumetric efficiency defined objective function calculations carried using parallelized computational code consisting one dimensional model unsteady compressible gas flow taking place intake exhaust ducts single zone combustion model cylinder processes iii optimization routine based differential evolution technique three sets optimization calculations conducted first one intake duct length optimization variable found optimal inlet duct lengths vary becoming shorter engine speed increased second set calculations intake exhaust duct lengths taken optimization variables resulting optimal intake duct lengths quite similar first set addition optimal exhaust duct lengths resulted close value optimal intake duct lengths except highest speeds decreasing tendency engine speed raised supplanted opposite tendency third set calculations crank angles defining valve synchronism optimization variables found optimal valve timing produced gain volumetric efficiency similar obtained optimal duct lengths elsevier ltd rights reserved
objectives assess effect incentive size response rates data quality cost digestive health status mail survey community sample health plan enrollees data sources setting study population selected database enrollees various health plans obligated receive care park nicollet clinic healthsystem minnesota large multispecialty group minneapolis minnesota nearby suburbs study design total healthsystem minnesota enrollees randomly assigned receive survey incentive response rates incentive level determined data quality indicated item nonresponse scale scores measured total cost cost per completed survey calculated principal findings response rate among enrollees receiving percent significantly higher among receiving percent differences pronounced first wave data collection data quality differ two incentive groups total cost per completed survey higher condition condition conclusions incentive resulted higher response rate among community patient sample one mailing incentive however response rates condition approached level incentive costs significantly lower full follow protocol completed response rates marginally increased follow phone calls incentive level influence data quality results suggest survey budget limited timeline critical incentive provides affordable means increasing participation
supporting positive development special needs child especially challenging parents separated divorced invariably increased need collaborative parenting wherein information shared intervention plans implemented effectively article evolving literature parental gatekeeping applied families special needs children offers useful model understanding strengths liabilities parenting relationships describe typical unique gatekeeping dynamics occur children suffer developmental physical psychiatric syndromes require specific treatment specialized parenting skills examples restrictive facilitative gatekeeping described manifest families implications decision making also discussed key points family court community understand unique demands separated divorced families special needs child given syndrome present well severity condition understand required parents terms cooperation collaboration typical developmentally based parenting plans may apply family special needs child aware parents handle safety basic welfare issues child understand parent approach including versus restricting parent access information child well physical access child understand unique ways subtle alienation enmeshment may manifest families special needs child many timely decisions need made families presumption joint legal decision making across board may practical effective
fractures olecranon common fractures elbow adults due dislocating force triceps muscle internal fixation treatment choice fractures olecranon without contraindications infection severe soft tissue damage dorsal approach olecranon patient prone position open reduction internal fixation tension band wiring plate fixation according fracture pattern treatment goal early functional mobilization load bearing allowed weeks full load bearing allowed fracture healing quality published studies concerning surgical treatment olecranon fractures poor published functional results predominantly good excellent hardware removal often required
intimate partner violence ipv potentially severe long lasting mental health consequences survivors including elevated symptoms diagnoses posttraumatic stress disorder ptsd depression generalized anxiety disorder gad current study examined relationship three self report measures psychological distress ratings obtained corresponding clinician administered measures women seeking assessment mental health problems following ipv ptsd symptoms assessed using self report impact event scale revised ies interview based clinician administered ptsd scale caps depression symptoms assessed using self report beck depression inventory bdi depressive disorders sections clinician administered anxiety disorders interview schedule adis anxiety symptoms assessed using self report beck anxiety inventory bai clinician administered gad section adis results indicated psychological distress prevalent sample receiving ptsd diagnosis diagnosed depressive disorder meeting criteria gad although self report measure significantly positively correlated corresponding clinician administered measure rates diagnostic concordance mixed bdi showed high degree agreement adis depression section ies caps discordant classifying ptsd bai acceptable sensitivity poor specificity relation adis gad section findings suggest multiple assessment modalities considered rating symptoms estimating prevalence diagnoses among survivors ipv
last decade validity relevance dominance model regularly put question regarding relationships canids like dogs wolves consequently human dog relationships well concept underlying model scientifically defined intervening variable reflecting status difference individuals applicable formal status signals symbolize long term relationship individuals resulting formalized dominance hierarchy article reviews basics underlying concept dominance reflects value importance new quantitative studies applicability concept dominance domestic dogs conclusions first formal dominance present domestic dog expressed context independent unidirectional formal status signals consequently formal dominance submission plays important role assessing status dog dog relationships second nonverbal status related communication humans resembles dogs considerable degree hence dogs may well able interpret human status related nonverbal communication perspective dominance therefore also likely play role human dog relationships hence dominance concept might useful explain development certain problems dog dog dog human relationships however enforcing dominant status human may entail considerable risks therefore avoided elsevier inc right reserved
development economic globalization cultivation minority secretary major follow principle compound talents training mode improve overall quality talent minority secretary major secretary major training plan shortage teaching content lacks cross cultural communication training program teaching mission objectives new secretary professional competence teachers enough teaching method traditional curriculum unreasonable based situation paper digitization drm solutions using drm digital control program based multivariate intelligent teaching reform program talent training paper establishes develops odrl talent model achieves segmentation description dynamic segmentation authorization tasks contents minority secretary major secretary courses also achieves secondary development drm odrl control model verifies feasibility reliability training mode using teaching effect evaluation method openapi provides reliable theoretical basis reform minority secretary major training model
quantitative trait locus qtl mapping significance putative qtl often determined using permutation testing computational needs calculate significance level immense even permutations needed previously introduced prunedirect algorithm multiple qtl scan epistatic interactions algorithm specific strengths permutation testing present flexible parallel computing framework identifying multiple interacting qtl using prunedirect algorithm uses map reduce model implemented hadoop framework implemented widely used software tool among geneticists enables users rearrange algorithmic steps adapt genetic models search algorithms parallelization steps needs flexible way work underlines maturity accessing distributed parallel computing computationally demanding bioinformatics applications building workflows within existing scientific environments investigate prunedirect algorithm comparing performance exhaustive search direct algorithm using framework public cloud resource find prune direct vastly superior permutation testing perform permutations qtl problem hours using cloud processes show framework scales almost linearly qtl search
experimental advanced superconducting tokamak east device began operation east visualization work paid attention simulating running state inner structure veast system developed display model east facility diagnostic data based javad compared veast system new system named autosterescopic scientific east aseast using client server structure combination technology opengl open source software system computer graphics visualization called vtk visualization toolkit libraries graphical user interface gui developed improve effect virtual east visualize experimental data aseast used get access information east physical properties addition general system aseast supports wide variety formats visualization result output corresponding format input order improve rendering speed used classic qem algorithm simplify models preprocess stage effect made investigation survey revealed system good effect elsevier rights reserved
leadership defined social influence process mediated information communication technology produce change behavior performance individuals groups organization study investigates leadership practices among users school virtual learning environment performed two stages first semi structured interviews school administrators teachers students parents school software experts conducted qualitative data collected interviews coded analyzed using open axial coding procedures result leadership model emerged data consisted eight themes leadership quality seven core factors namely readiness practices strategies support culture needs obstacles second validity reliability model ascertained quantitative survey study involving school administrators findings study established grounded model leadership practices schools elsevier ltd rights reserved
novel system decoupling approach sda enables three degree freedom dof bridge flutter analysis proposed study simultaneously investigate relationships modal parameters flutter derivatives based incentive feedback mechanisms aerodynamic coupled system conveniently decoupled iterative solution based sda unnecessary simultaneously calculate multiple frequencies determining modal parameters eventually quantifying critical flutter wind velocity efficacy accuracy sda verified using numerical example thin flat plate coupling effects among three dofs influence flutter derivatives flutter performance quantified using newly proposed method flutter mechanisms thin flat plate bluff deck section akashi kaikyo suspension bridge numerically examined difference common grounds two typical flutter phenomena summarized results sda show good agreement commonly used complex eigen value analysis ceva akashi kaikyo bridge bluff deck section analytical results dof coupled flutter coincident dof case experimental observations study provides significant insights flutter characteristics dof bridges explores roles played various parameters modifying bridge deck aerodynamics evolution modal coupling increasing wind velocity simplified formulation concerns presented acceptable accuracy flutter parameters also achieved torsional modal branch validated using thin flat plate akashi kaikyo bridge bluff deck
objective chronic myeloproliferative neoplasms cmpns include polycythemia vera essential thrombocythemia primary myelofibrosis pmf philadelphia negative malignancies characterized clonal proliferation one several lineages aim report determine demographic features disease characteristics treatment strategies survival rates patients cmpns turkey materials methods across turkey centers enrolled study retrospectively evaluated cmpn patients results including pmf results jakvf mutation found positive patients patients patients pmf thrombosis bleeding diagnosis occurred patients patients pmf patients respectively six hundred eight patients received cytoreductive therapy commonly used drug hydroxyurea leukemic fibrotic transformations occurred rates estimated overall survival pmf patients years respectively significant differences survival pmf patients years conclusion patients results generally compatible literature findings except relatively high survival rate pmf patients hydroxyurea commonly used cytoreductive therapy study reflects demographic features patient characteristics treatments survival rates turkish cmpn patients
objective aim report three new cases lacrimal neuralgia response superficial nerve blocks background lacrimal neuralgia recently described pain territory supplied lacrimal nerve lateral upper eyelid adjacent area temple pain typically accompanied tenderness palpation lacrimal nerve superoexternal angle orbit methods january june prospective identified three cases lacrimal neuralgia among patients attending headache unit tertiary hospital anesthetic blocks performed cases inserting needle emergence nerve injecting bupivacaine subcutaneously results three women aged presented pain territory supplied lacrimal nerve two localized pain small area right temple remaining patient pain right upper lateral eyelid small area lower lateral eyelid pain continuous two patients episodic attacks lasting hours one patient patients tenderness palpation lacrimal nerve anesthetic blocks confirmed diagnosis lacrimal neuralgia provided patients long lasting pain relief conclusions lacrimal neuralgia considered among neuralgic causes orbital periorbital pain superficial nerve blocks may assist clinicians diagnosis may also therapeutic option
context analyze dynamic changes serum thyrotrophin receptor antibody trab thyroid peroxidase antibody tpoab graves disease patients radioactive iodine rai treatment investigate trab tpoab play role occurrence early hypothyroidism therapy graves hyperthyroidism subjects methods total patients newly diagnosed selected study clinical laboratory assessment performed months therapy chemiluminescent immunoassays used detect serum free triiodothyronine free thyroxine sensitive thyroid stimulating hormone tsh tpoab concentration radio receptor assay used measure serum trab concentration according early onset hypothyroidism year rai therapy patients divided early hypothyroidism group group non early hypothyroidism group group results groups serum trab tpoab increased months reached highest level months returned baseline months rai therapy trab showed significant difference two groups months serum tpoab group higher group months rai therapy conclusions serum trab tpoab closely related occurrence early hypothyroidism play important role judging prognosis treatment graves disease
mathematica application providing user graphical interface gui presented published used interactively explore image filtering segmentation methods analyse variously shaped particles microscopic image application functionality designed around mathematica built image processing capability custom designed functions specialized segmenting greyscale microscope images main contribution specially designed gui allows characterization segmented particles based morphological properties focus given differentiation shapes segmented particles application provides convenient way navigating myriad ways analyse particles micrographs elsevier rights reserved
background aimsscreening brief intervention referral treatment programs promoted widely federal policy little known efficacy component referral treatment brief intervention motivating patients unhealthy drug use identified screening use addiction treatment study aimed compare receipt addiction treatment following two types brief intervention drug use versus intervention control group among primary care patients screening positive drug use designsecondary analyses single site randomized controlled trial settingmassachusetts usa participantsa total adults alcohol smoking substance involvement screening test assist drug specific scores interventionsrandom assignment minute brief negotiated interview bni conducted health educators minute adaptation motivational interviewing masters level counselors motiv received list treatment mutual help resources intervention protocols included dedicated staff treatment referrals measurementsreceipt addiction treatment within months study entry assessed state wide database hospital electronic medical record linked trial data findingsamong participants main drugs used marijuana cocaine opioids met past year drug dependence criteria short form composite international diagnostic interview motiv bni control participants addiction treatment receipt within months study entry significant difference addiction treatment receipt bni versus control adjusted odds ratio aor confidence interval hochberg adjusted motiv group lower odds linking treatment aor hochberg adjusted compared group conclusionbrief intervention delivered primary care screen identified drug use increase addiction treatment receipt significantly motivational interviewing approach appeared counterproductive
increasing amount available data need classification large data volumes permanently growing order cope challenge neural classifiers adapted large scale data present well scalable extension fuzzy adaptive resonance associative map aram neural network specially developed quick classification high dimensional large data extension aims increasing classification speed adding extra layer clustering learned prototypes large clusters enables activation one clusters small fraction prototypes reducing classification time significantly introduce two methods adapt extension multi label classification task
context increasing dependence society software driven systems led software reliability become key factor well making highly active research area hundreds works published every year would however appear activity much reduced regards apply representative international standards product quality industrial environments works standard based software reliability modeling srm surprising given relevance international standards industry objective identify analyze existing works modeling software reliability based international standards starting point reliability assessment proposal based iso iec software product quality requirements evaluation square series method work methodology based guidelines provided evidence based software engineering systematic literature reviews slr results total works obtained result slr search primary studies selected data filtering scrutiny thirty thoroughly analyze results obtained show limited application srm particularly industrial environment conclusion analysis point complexity proposed models together difficulties involved applying management engineering activities root cause considered limited application various stakeholder needs also point paramount importance better covered industrial applicability proposed models increased elsevier rights reserved
background constitutional translocations sex chromosomes rather rare humans breakpoints frequent breakpoints short arm chromosome form one subgroup giving rise derived chromosome centromeres chromosomes dic report rare congenital chromosomal aberration dic adult male case presentation primary myelofibrosis malignant haematological disease diagnosed year old man following liver transplantation hepatocellular carcinoma analysis bone marrow sample karyotype dic detected mitoses analysed verified multicolour fluorescence situ hybridization mfish cytogenetic examination stimulated peripheral blood cells revealed constitutional karyotype dic cell line confirmed fish interphase nuclei sry locus present dicentric chromosome cgh snp array illumina revealed gain mbp chromosome kbp microdeletion including shox gene also confirmed fish shox encodes transcriptional factor regulates growth long bones deletion shox gene together madelung deformity forearm short stature proband led diagnosis leri weill dyschondrosteosis lwd gain almost whole chromosome mbp considered variant klinefelter syndrome levels gonadotropins testosterone consistent gonadal dysfunction malformation right external ear detected conclusions reported structural aberration sex chromosomes dic related genomic imbalance associated two known hereditary syndromes lwd variant identified proband advanced age breakpoints involve cancer genes inferred two malignancies proband caused abnormality possible influence shox haploinsufficiency growth regulation auricular chondrocytes discussed
psychopathy one strongest predictors future offending often included important item structured risk assessment tools recent research recognizes importance psychopathy offenders intellectual disabilities oids study presents data clinical utility psychopathy checklist revised pcl psychopathy checklist screening version pcl among oids psychometric properties instruments similar although pcl might minor advantages first absence pcl item marital relationships appeared difficult score second pcl less time consuming extended counterpart future research confirming results larger cohorts recommended
background omega polyunsaturated fatty acids fas several beneficial effects cardiovascular disease risk factors effects risk profile may mediated several factors including epigenetic modifications objective investigate using genome wide dna methylation analyses methylation changes following supplementation overweight obese subjects identify specific biological pathways potentially altered supplementation results blood leukocytes genome wide dna methylation profiles overweight obese subjects week supplementation fas compared using genomestudio software supplementation cpg sites assigned genes differentially methylated fdr corrected diffscore vertical bar vertical bar similar using ingenuity pathway analysis system total pathways significantly overrepresented following supplementation among pathways related inflammatory immune response lipid metabolism type diabetes cardiovascular signaling changes methylation levels cpg sites within akt atf hdac igfbp correlated changes plasma triglyceride glucose levels well changes ratio total cholesterol hdl cholesterol following supplementation conclusions data provide key differences blood leukocytes dna methylation profiles subjects following supplementation brings new potential insights metabolic pathways underlying effects fas health
cardiovascular diseases leading cause mortality among women several countries early detection subclinical atherosclerosis could enable adoption preventive measures avoid cardiovascular events study aimed determine prevalence brazilian asymptomatic postmenopausal women framingham risk score frs low intermediate groups computed tomography ultrasound scans performed asymptomatic postmenopausal women years age survey coronary artery aortic calcification scan assess carotid intima media thickness cimt identify carotid plaques mean frs prevalence increased cimt carotid plaques increased cimt plaques coronary artery calcification cac aortic calcification respectively normal imaging tests found defined least one abnormal imaging test associated age frs waist rip ratio systolic diastolic blood pressure hdl apoa levels apoa apob ratio logistic regression associated higher age lower apoa levels prevalent brazilian postmenopausal women low intermediate risk groups frs associated higher age lower levels apoa carotid atherosclerosis common presentation group
summary manuscript describes role low vitamin bone metabolism klinefelter subjects low vitamin frequent condition seems important testosterone inducing low bone mineral density bmd osteoporosis supplementation vitamin restores bmd years treatment whereas testosterone alone seems ineffective introduction decreased bone mineral density bmd klinefelter syndrome frequent traditionally related low testosterone levels however low bmd observed also patients normal levels replacement therapy necessarily increase bone mass patients nothing known vitamin levels supplementation study determine vitamin status bone mass subjects compare efficacy therapy vitamin supplementation bmd methods total non mosaic patients age matched male controls evaluated reproductive hormones hydroxyvitamin pth bone densitometry dual energy ray absorptiometry dexa patients hypogonadism hydroxyvitamin deficiency treated gel calcifediol evaluated months treatment results hydroxyvitamin levels significantly lower patients respect controls significantly lower lumbar femoral bmd percentage osteopenia osteoporosis subjects hydroxyvitamin deficiency higher respect subjects normal hydroxyvitamin related presence absence low levels subjects treated calcifediol calcifediol significant increase lumbar bmd treatment difference found treated group conclusion data highlight low hydroxyvitamin levels seem critical role low levels inducing low bmd subjects furthermore vitamin supplementation seems effective replacement therapy alone increasing bmd
galvanized steel widely used transportation industry however corrosion performance products highly affected exposed chloride containing environments one alternative rich metal coatings known notably improve corrosion protection steel substrate enhanced barrier properties provided although hot dip aluminum based coatings steel nowadays used many applications little known electrochemical behaviour coatings work studies corrosion behaviour containing metal coated steel odd random phase multisine electrochemical impedance spectroscopy orp eis used monitoring corrosion evolution continuous immersion nacl solution technique allows rapid screening corrosion processes due reduced measurement time respect conventional single sine techniques extra information concerning linearity stationarity noise level also supplied valuable data quality evaluation fitting different equivalent electrical circuits proposed validity discussed based physical phenomena also taking quality obtained data statistical evaluation fittings account elsevier ltd rights reserved
pyridylmethylsulfonamide series first reported example positive allosteric modulators pam mglu receptor hydroxyacetophenone scaffold second series mglu pams identified series molecules potent mglu potentiators possess significant cyslt cysteinyl leukotriene receptor antagonist activity showing vivo efficacy dural plasma protein extravasation ppe model migraine paper describe dual sar pharmacokinetics preclinical vivo efficacy data tetrazole containing hydroxyacetophenone scaffold elsevier ltd rights reserved
urging needs decrease fuel consumption environment pollution energy saving emission reduction technologies ice internal combustion engine industry developed thermal orc oil storage organic rankine cycle system constructed preliminarily tested whr waste heat recovery exhaust gas diesel engine heat balance test diesel engine without orc conducted first investigate varying property exhaust gas orc system tested show ability high temperature variation exhaust gas results show thermal oil effectively dropped working temperature organic fluid less degrees much lower decomposition temperature many organic fluids also thermal oil brought significant inertia response system could positive variation engine condition order learn operating characteristics orc system impact important parameters investigated quantitatively well performance orc system results show within given range higher evaporating pressure obviously improve performance orc impact superheat nearly negligible elsevier ltd rights reserved
despite considerable progress hematological malignancies biology last decades translation clinical benefit remains major challenge improve patient selection identify patients likely benefit phase trials designed validated independent cohort simple prognostic score treatment outcome toxicity survival data consecutive patients enrolled phase trials reviewed january february validated results prospectively collected cohort phase trials february may patients within median follow months range months median progression free overall survival respectively months confidence interval months best overall response disease control rates similar salvage regimens respectively multivariate analysis independent prognostic factors designed prospectively validated simple prognostic score based histological subtype performance status albumin patients low risk score experienced significantly better compared patients intermediate high score median months hazard ratio data indicate safety efficacy phase trials significant number relapsed refractory patients clinical benefit achieved half patients simple scoring system offers valuable selection tool encouraging patient inclusions phase trials
disjunction ecological socioeconomic sciences one main obstructions current human natural integrated systems research therefore gridded gis technology introduced attempt achieve spatial flow analysis water pollution eco natural systems unified gis platform input output table one dimensional water quality model chosen manifest spatial economic flows spatial natural flows water pollution separately finally comprehensive effect spatial circulation water pollution eco natural systems assessed case study framework carried changzhou district taihu lake china main results show following cod chemical oxygen demand direct emissions represent characteristics high intensity clustering industrial regions control unit largest secondary emissions unit representing total whereas emissions primary industry tend low intensity widespread gray virtual water flow primary industry heavy industries except chemical industry main flow type transfer amount adds inter units largest occupation water environment capacity wec upstream downstream nearly interaction positive negative functions economic flows natural flows final effect pollution transfer may offset environmental degradation environmental improvement study could provide basis ecological compensation environmental exteriority optimization industrial structure layouts elsevier ltd rights reserved
human responses android humanoid robots become important topic social scientists due increasing prevalence social service robots everyday life present research connects work effects lateral sideward head tilts eminent feature nonverbal human behavior experience android humanoid robots two experiments influence lateral head tilts user perceptions android humanoid robots examined photo portrayals three different robots asimo kojiro telenoid manipulated stimuli included head tilts degrees degrees left tilt degrees degrees right tilt degrees upright position compared upright head posture found higher scores attributed human likeness cuteness spine tinglingness identical robots conveyed head tilt results perceived warmth eeriness attractiveness dominance varied robot head tilts yielded effects implications development marketing android humanoid robots discussed published elsevier ltd
automatic control gene expression living cells paramount importance characterize endogenous gene regulatory networks synthetic circuits addition technology used maintain expression synthetic circuit components optimal range order ensure reliable performance present microfluidics based method automatically control gene expression tetracycline inducible promoter mammalian cells real time approach based negative feedback control engineering paradigm validated method monoclonal population cells constitutively expressing fluorescent reporter protein deyfp downstream minimal cmv promoter seven tet responsive operator motifs cmv tet cells also constitutively express tetracycline transactivator protein tta cells grown standard growth medium tta able bind cmv tet promoter causing deyfp maximally expressed upon addition tetracycline culture medium tta detaches cmv tet promoter thus preventing deyfp expression tested two different model independent control algorithms relay proportional integral force monoclonal population cells express intermediate level deyfp equal maximum expression level min control input either tetracycline rich standard growth medium demonstrated relay controllers regulate gene expression desired level despite oscillations dampened case controller around chosen set point
review examines attention deficit hyperactivity disorder adhd child adult form various presentations hyperactive impulsive inattentive combined particular focus environmental incl social factors lifestyles comorbidities argued adhd best understood holistic interactive context vast empirical literature presented illustrate point environmental factors include stress general well exposure toxins phthalates bisphenol social factors illustrated effects social deprivation seduction unhealthy lifestyles maternal lifestyle pregnancy pointed particularly exposure nicotine alcohol caffeine drugs even seemingly benign medications like acetaminophen tend related adhd family environment discussed respect protective effect mainly authoritative autocratic parenting styles societal factors include mainly economic political issues income inequality poverty low ses adhd risk factor growing moral dilemma humanistic effort globally spread knowledge adhd medicalization commercialization disorder second part review devoted adhd related lifestyles resulting comorbidities food addiction obesity substance abuse electronic media dependencies conduct personality disorders although adhd neurodevelopmental disorder assessment treatment also linked environmental behavioral social factors interactions
background oxidation methionine residue position sulphoxide sulphoxide ability deeply modify wild type neurotoxic action previous studies suggest nucleated cells lower toxicity sulphoxide might result structural alteration elevation methionine sulphoxide reductase msra activity mrna levels design basis hypothesised red blood cell rbc cell devoid almost completely msra activity shares nucleated cells antioxidant system induced methionine sulphoxide responsible lower toxicity sulphoxide rbc results supporting hypothesis found low toxicity sulphoxide rbc correlated pentose phosphate pathway ppp flux increase event associated low level methionine oxidation total proteins none effects observed cells exposed native discussion results outline importance redox state methionine modulation abmediated events suggest important protective role ppp rbc patients affected alzheimer disease
objective neck pain common rheumatoid arthritis ankylosing spondylitis investigated correlation bone marrow edema bme magnetic resonance imaging mri association clinical complaints neck pain methods cervical spine short tau inversion recovery mri mri patients patients complaining neck pain obtained clinical laboratory data available bme scored blinded readers using modification published score including various cervical sites degenerative changes also quantified results patients predominantly women mean age years reactive protein crp pain score bme detected patients involving atlantoaxial region vertebral bodies facet joints spinous processes degenerative changes identified patients also bme vertebral bodies differences found patients versus without cervical bme clinical assessments numeric rating scale pain median interquartile range funktionsfragebogen hannover northwick pain score crp patients degenerative changes symptom duration longer patients without yrs conclusion small study patients complaining neck pain bme found many different cervical sites including facet joints spinous processes however occurrence severity bme correlate severity neck pain
paper discuss analysis based interview session teaching automotive practical work vocational colleges six teachers expert automotive interviewed three major themes discussed analyze teachers feedback interview categorized three major themes teaching methods introduction body conclusion discussion start teaching teachers prefer use demonstration sketching questioning technique introduction chose demonstration question answer hands problem solving approach teaching body content automotive practical work end teaching session teachers prefer summarize topic ask students write report teachers agreed deliver variety methods creative teaching methods time constraints students complete task within two hours answers teaching bodies teaching practical work teachers give students problems let students solve creativity enhance students knowledge give opportunity explore current situations automotive development reflection conclusion session respondents asked encourage students particular way summary teachers applied method teaching based curriculum need students need based level difficulties task given
apoptosis plays important role myocardial loss acute myocardial infarction participates process subsequent left ventricular remodeling development symptomatic heart failure finding sensitive apoptotic marker would help prognostic stratification patients acute myocardial infarction offer new therapeutic strategies thus great importance several studies suggest tumor necrosis factor related apoptosis inducing ligand trail represents promising marker prognosis patients acute myocardial infarction review article provides overview current knowledge role apoptosis ischemic heart disease highlights potentially beneficial apoptotic markers clinical practice
acceptance intention use mobile learning topic growing interest field education although considerable amount studies investigating mobile learning acceptance little research exists investigates driving factors influence students intention use mobile technologies assessment purposes aim study provide empirical evidence acceptance mobile based assessment mba assessment delivered mobile devices technologies proposed model mobile based assessment acceptance model mbaam based technology acceptance model tam mbaam extends tam context mba adding perceived ease use perceived usefulness constructs facilitating conditions social influence mobile device anxiety personal innovativeness mobile self efficacy perceived trust content cognitive feedback user interface perceived ubiquity value investigates impact behavioral intention use mba students european senior level secondary school experienced series mobile based assessments three week period structured equation modeling used analyze quantitative survey data according results mbaam explains predicts approximately variance behavioral intention use mobile based assessment study provides better understanding towards developing mobile based assessments support learners enhance learning experience promote learning taking advantage distinguished features mobile devices may offer implications discussed within wider context mobile learning acceptance research elsevier ltd rights reserved
progressive loss nigro striatal dopaminergic terminals parkinson disease vivo quantitative imaging dopamine containing neurons animal models critical importance preclinical evaluation highly awaited disease modifying therapies among existing methods high sensitivity positron emission tomography pet attractive achieve goal aim study perform quantitative comparison brain images obtained hydroxydopamine ohda lesioned rats using two dopaminergic pet radiotracers namely fluoro dihydroxyphenyl alanine fdopa fluoro tyrosine fmt imaging signal theoretically less contaminated metabolites hypothesized latter would show stronger relationship behavioural post mortem measures striatal dopaminergic deficiency used within subject design measure striatal fmt fdopa uptake eight partially lesioned eight fully lesioned ten sham treated rats animals pretreated aromatic amino acid decarboxylase inhibitor catechol methyl transferase inhibitor also given fdopa pet quantitative estimates striatal uptake computed using conventional graphical patlak method striatal dopaminergic deficiencies measured apomorphine induced rotations post mortem striatal content observed strong relationship fmt fdopa estimates decreased uptake denervated striatum using tissue derived uptake rate constant however fmt succeeded discriminate partial full ohda lesion correlated well post mortem striatal content study indicates fmt could sensitive respect fdopa investigate terminals loss ohda rats open way invivo aromatic amino acid decarboxylase activity targeting future investigations progressive models
objectives scotland women get emergency contraception pharmacies pharmacists currently provide effective ongoing contraception pilot study aimed determine feasibility larger study designed ascertain pharmacy based interventions increase uptake effective contraception study design pilot study women presenting levonorgestrel community pharmacies edinburgh pharmacies cluster randomized provide either standard care one two interventions one packet progestogen pills pops giving women month arrange ongoing contraception invitation present empty packet family planning clinic fpc contraceptive advice rapid access results one hundred sixty eight women recruited pharmacies pop rapid access standard care groups respectively telephone follow conducted successfully women weeks later determine current contraceptive use pop arm women used pills provided women rapid access arm attended fpc proportion women using effective contraception follow significantly greater pop rapid access groups compared standard care relative probability woman using effective method contraception versus barrier method use confidence interval pop group rapid access group conclusions promising pilot study suggests simple pharmacy based interventions may increase uptake effective contraception larger study required provide validation findings elsevier inc rights reserved
objectives aim survey gain understanding women usage patterns attitudes towards emergency contraception morning pill gain insight role attitudes pharmacists providers emergency contraception methods part international emergency contraception research initiative approximately women years nearly pharmacists countries western central eastern europe central asia completed questionnaires via web based interrogation computer assisted paper assisted personal interviews results common almost countries cultures awareness emergency contraception high respondents except kazakhstan usage generally low austria czech republic spain better underlying protection hormonal contraceptives male condoms would meant less need emergency contraception bulgaria lithuania romania russia greater dependence less reliable contraceptive methods calendar withdrawal associated higher use emergency contraceptive pill also higher abortion rates overt rejection emergency contraception event accident low except countries austria poland misperception acts abortifacient common except bulgaria pharmacists elsewhere tended limited knowledge moralistic attitudes towards emergency contraception conclusions improved educational efforts probably country specific required increase use highly effective methods regular contraception overcome barriers acceptance emergency contraception suitable postcoital solution avoid unwanted pregnancy abortion
robot assisted surgeries integrated leading paradigm shift surgical fields emergence minimally invasive surgery mis especially natural orifice transluminal endoscopic surgery notes various benefits minimization side effects enhancement precise surgical procedures faster recovery surgery patients take however order effectively employ exploit surgical robots numerous technical challenges need addressed among actuators play vital role provide deeper understanding current actuators driven surgical robot study comprehensively review four main types transmission systems namely cable driven mechanism flexible fluidic actuators smart material actuators magnetic actuators terms conceptual designs modelling control well advantages disadvantages profound discussions recommendations future actuators driven surgical robots also pointed give roadmap surgical field elsevier rights reserved
management post transplantation bone disease complex problem remains appreciated clinical practice patients pre existing metabolic bone disorder impacted use immunosuppressive medications glucocorticoids calcineurin inhibitors variable post transplantation renal allograft function post transplantation diabetes mellitus treatment post transplantation bone loss begin pre transplantation patients active transplant waiting lists screened bone disease patients also encouraged take preventative measures osteoporosis regular weight bearing exercise smoking cessation reducing alcohol consumption biochemical abnormalities disordered mineral metabolism corrected prior transplantation wherever possible abnormalities commonly persist post transplant hypophosphatemia persistent hyperparathyroidism low vitamin levels regularly monitored treated bone loss greatest first months post transplantation period intervention likely greatest benefit strong evidence bisphosphonates prevent post transplantation bone loss however data lacking clearly extends reduction fracture incidence denosumab potential alternative vitamin receptor agonists bisphosphonates reducing post transplantation bone loss however studies needed demonstrate safety patients significantly reduced estimated glomerular filtration rate clinical judgement remains cornerstone complex clinical problem providing strong rationale formation combined endocrinology nephrology clinics treat patients chronic kidney disease mineral bone disorder transplantation
eed leadership energy environmental design one popular globally recognized green building standards leed evaluating sustainable effects site location transportation ecosystem human life critical difficult task credits regarding matters require experience time labor manual calculations recent years many studies conducted enhance application building information modeling bim leed certification however application bim leed site location transportation analysis usually considered impractical due lack powerful map application present bim products aim research develop framework integration bim web map service wms technologies leed location transportation analysis using autodesk revit api google maps api development tools research converts integration model leed bim plugin autodesk revit streamline certification process site location transportation analysis leed authors published elsevier ltd
objective structural model updating reduce inherent modeling errors finite element models due simplifications idealized connections uncertainties material properties updated models less discrepancies real structures give precise predictions dynamic behaviors future analyses however model updating becomes difficult applied civil structures large number structural components complicated connections paper full scale model major long span bridge updated improved consistency real measured data two methods applied improve model updating process first method focuses improving agreement updated mode shapes measured data nonlinear inequality constraint equation used optimization procedure providing capability regulate updated mode shapes remain within reasonable agreements observed interior point algorithm deals nonlinearity objective function constraints second method finds efficient updating parameters systematic way selection updating parameters models essential successful updating result parameters directly related modal properties dynamic systems depth sensitivity analysis carried effort precisely understand effects physical parameters model natural frequencies based sensitivity analysis cluster analysis conducted find efficient set updating parameters elsevier ltd rights reserved
plant cell culture useful technology production secondary metabolites commercial pharmaceutical value rheology morphology aggregation cell suspension different applications flow systems bioreactor design unit operations suggests solutions mixing mass transfer hydrodynamic stress cell growth problems study morphological aspects associated elliptical form factor tendency form cell aggregates azadirachta indica borojoa patinoi thevetia peruviana cell cultures evaluated shake flasks rheological behavior rheograms cell concentrations dwl also evaluated data properties parameters like apparent viscosity reynolds number phase state volumetric power calculated shake flasks results showed dilatant behavior culture medium pseudo plastic behavior cell cultures last behavior increases cell concentration size cell aggregates rheograms cell concentrations indica significantly different two species culture conditions like shaker orbit diameters flask volumes recommended order favor adequate cell growth mass transfer plant cell cultures elsevier rights reserved
routing underwater wireless sensor networks uwsn important challenging activity due nature acoustic channels harsh environment paper extends previous work salti proceedings cyber enabled distributed computing knowledge discovery cyberc shanghai proposed novel multipath grid based geographical routing mggr protocol uwsns extended work emggr viewed network logical grids routing performed grid grid manner via gateways use disjoint paths relay data packets sink node algorithm consists three main components gateway election algorithm responsible electing gateways based locations remaining energy level mechanism updating neighboring gateways information allowing sensor nodes memorize gateways local neighboring cells packet forwarding mechanism charge constructing disjoint paths source cells destination cells forwarding packets destination dealing holes cells gateways network performance emggr assessed using aqua sim based simulator uwsns results show emggr energy efficient protocol simulation setups used study moreover emggr also maintain good delivery ratio end end delay
split feasibility problem sfp refers task finding point belongs given nonempty closed convex set whose image bounded linear operator belongs another given nonempty closed convex set promising applicability modeling wide range inverse problems motivated increasingly data driven regularization areas signal image processing statistical learning paper study regularized split feasibility problem rsfp provides unified model treating many real world problems exploiting split nature rsfp shall gainfully employ several efficient splitting methods solve model consideration remarkable advantage methods lies easier subproblems sense resulting subproblems closed form representations efficiently solved high precision interesting application apply proposed algorithms finding dantzig selectors addition demonstrating effectiveness splitting methods computational results synthetic real medical data sets
urogenital dysfunction commonly reported parkinson disease history taking bladder diary form cornerstone evaluation assessment lower urinary tract lut symptoms include urinalysis ultrasonography urodynamic studies help evaluate concomitant urological pathologies benign prostate enlargement antimuscarinic medications first line treatment overactive bladder oab symptoms solifenacin specifically studied antimuscarininc drugs may exacerbate related constipation xerostomia caution advised using medications individuals cognitive impairment suspected desmopressin effective management nocturnal polyuria reported common intradetrusor injections botulinum toxin shown effective detrusor overactivity however associated risk urinary retention neuromodulation promising minimally invasive treatment related oab symptoms erectile dysfunction commonly reported first line treatments include phosphodiesterase inhibitors patient tailored approach required optimal management urogenital dysfunction
recent advances materials engineering enabled photovoltaic cells fabricated solid state semiconductors photosensitive organic dyes photoactive proteins one type organic cell based natural light harvesting protein bacteriorhodopsin found plasma membrane salt marsh archaebacteria exposed sunlight molecule acts simple proton pump transports hydrogen ions cytoplasmic extracellular side transmembrane ion channel two types cells comprised photosensitive dry aqueous wet thin films described paper self assembled monolayer oriented purple membrane patches protein created bio functionalized gold surface using biotin molecular recognition technique dry monolayer covered optically transparent indium tin oxide ito electrode complete dry device contrast aqueous cell created immobilizing monolayer coated porous substrate inserting assembly two micro reservoirs filled kcl solutions platinum wire probes inserted opposing liquid reserviors near porous monolayer dry cell generated photo electric response aqueous produced although generated voltages appear small may sufficient power various microelectromechanical systems mems microfluidic devices
lipids concentrated source energy fat soluble vitamins essential fatty acids carriers flavours many bio active compounds important role maintaining physiological functions biological body moringa oleifera native himalaya widely grown many asian african countries seed oil content range moringa oleifera oil moo light yellow colour mild nutty flavour fatty acids composition suggests moo highly suitable edible non edible applications moo extremely resistant autoxidation used antioxidant long term stabilization commercial edible oils thermal stability moo greater soybean sunflower canola cottonseed oils high oleic contents moo believed capability increasing beneficial hdl cholesterol decreased serum cholesterol triglycerides moo applications also explored cosmetics folk medicines skin care formulations overall review focuses commercial production status food applications antioxidant characteristics health benefits thermal stability fractionation cholesterol contents medicinal nutraceutical action toxicological evaluation biodiesel production personal care formulations future perspectives moo stake holders process utilize moo new source edible oil industrial purpose
prime objective research work improve efficacy bcs class drug nabumetone nbm nanostructured lipid carrier nlc nbm developed using melt emulsification ultrasonication technique prior formulation development screening various solid lipids liquid lipids surfactants done suitable excipients selected nlc formulation optimized using box behnken design expert software optimization purpose independent variables taken lipid mix surfactant sonication time minute particle size pdi entrapment efficiency selected dependent variables optimized formulation characterized using photon correlation spectroscopy found average particle size polydispersity index pdi observed tem sem nlc particles found nearly spherical shape particle size nlc study almost matched average particle size determined photon correlation spectroscopy dsc thermogram nbm nlc endothermic peak drug degrees disappeared means drug fully dissolved lipid vitro release study developed formulation showed burst release followed slow diffusion based sustained release pharmacodynamic study shows better anti inflammatory effect almost times compared nbm suspension based data obtained vitro vivo studies concluded nlc promising carrier helps improving intestinal absorption orally administered nbm elsevier rights reserved
paper describes low voltage low power low pass filter low pass filter precedes converter called anti aliasing filter analog signal processing anti aliasing filter would one important circuits transceiver architecture filter located analog front end circuits dab receivers order butterworth low pass filter using proposed transconductore simulated cmos process project minimized power consumption maximized cut frequency anti aliasing filter circuit consumed watt power supply cut frequency mhz
hereditary angioedema hae typically presents childhood large gaps remain understanding natural history hae childhood examined age onset delay diagnosis androgen exposure influence ultimate disease severity large cohort patients hae median age first swelling years median age diagnosis years earlier onset symptoms correlated longer delays diagnosis predicted severe disease course including increased number attacks per year hospital admissions earlier age onset also significantly correlated increased perceived hae severity negative overall life impact use anabolic androgen observations highlight importance early hae diagnosis suggest necessity disease management plan diagnosis made
background evidence mice suggests brain infiltrating immune cells contribute neurodegeneration previously identified deleterious lymphocyte infiltration parkinson disease mice however remains controversial monocytes due artifact prone techniques used distinguish microglia aim reassess open question taking advantage recent recognition chemokine receptors ccr cxcr differentiate inflammatory monocytes microglia enabling test whether ccr monocytes infiltrate brain dopaminergic neurodegeneration whether contribute neuronal death revealed unexpected insights possible regulation monocyte attracting ccl induction methods used acute methyl phenyl tetrahydropyridine mptp mice assessed monocyte infiltration combining laser microdissection guided chemokine rna profiling substantia nigra immunohistochemistry ccr gfp reporter mice determine contribution neuronal loss used ccr deletion ccloverexpression reduce increase ccr monocyte infiltration cxcr deletion assess potential implication ccl regulation results nigral chemokine profiling revealed early ccl ccr axis induction suggesting monocyte infiltration mptp mice ccl protein showed early peak induction nigral astrocytes ccr gfp mice revealed early limited nigral monocyte infiltration however blocking infiltration ccr deletion influence neuronal loss contrast transgenic astrocytic ccl induction increased ccr monocyte infiltration neuronal loss mptp mice surprisingly ccl induction also detected mptp intoxicated cxcr deleted mice known present increased neuronal loss importantly cxcr ccl double deletion suggested increased neurotoxicity driven astrocytic ccl induction conclusions show ccr monocytes infiltrate affected cns level observed acute mptp mice contribute neuronal loss contrast underlying astrocytic ccl induction seemed tightly controled already moderate ccl induction led increased neurotoxicity mptp mice likely due increased ccr monocyte infiltration importantly found evidence suggesting neurodegeneration control mediated microglial cxcr signaling protects neurotoxic ccl induction astrocytes thus hinting endogenous mechanism limit neurotoxic effects ccl ccr axis
development communication technology intelligent terminal artificial attendance based intelligent terminal technology mobile communication technology replaced attendance replacement based basis existing research aloha anti collision strategy improved mobile positioning attendance firstly algorithm design gives terminal specific operation finally carried experiments comparative analysis simulation results show improved aloha algorithm outperforms traditional anti collision algorithm ensuring system shorter time delay effectively improve throughput performance
recent years seen increase popularity multivariate pattern mvp analysis functional magnetic resonance fmri data much lesser extent magneto electro encephalography eeg data present cosmomvpa lightweight mvpa mvp analysis toolbox implemented intersection matlab gnu octave languages treats fmri eeg data first class citizens cosmomvpa supports state art mvp analysis techniques including searchlight analyses classification correlations representational similarity analysis time generalization method used address data driven hypothesis driven questions neural organization representations within across space time frequency bands neuroimaging modalities individuals species uses uniform data representation fmri data volume surface eeg data sensor source level various external toolboxes directly supports reading writing variety fmri eeg neuroimaging formats applicable convert result integrated readily existing pipelines used existing preprocessed datasets cosmomvpa overloads traditional volumetric searchlight concept support neighborhoods eeg surface based fmri data supports localization multivariate effects interest across space time frequency dimensions cosmomvpa also provides generalized approach multiple comparison correction across dimensions using threshold free cluster enhancement state art clustering permutation techniques cosmomvpa highly modular uses abstractions provide uniform interface variety mvp measures typical analyses require lines code making accessible beginner users time expert programmers easily extend functionality cosmomvpa comes extensive documentation including variety runnable demonstration scripts analysis exercises example data solutions uses best software engineering practices including version control distributed development automated test suite continuous integration testing used proprietary matlab free gnu octave software complies open source distribution platforms neurodebian cosmomvpa free open source software permissive mit license website http cosmomvpa org source code https github com cosmomvpa cosmomvpa
objective study prospectively compare incidence pin tract infection pediatric supracondylar humerus fractures managed pin care daily every day weekly hypothesized differences three methods june may children supracondylar humerus fractures randomized postoperative pin care cleaning pin tracts daily group cases cleaning every days group cases cleaning weekly group cases three groups comparable respect age gender affected side body mass index bmi fracture type injury surgery time number intraoperative percutaneous pinning follow time collected data pin retention time union time pin tract infection average follow time group months group months group patient demographics intraoperative variables three groups comparable significant difference three groups found union time pin fixation time children cases pin tract infection grade infections checketts otterburns classification occurred around pin grade around found differences three groups regards frequency severity pin tract infections however complain pain frequent group two groups conclusions three methods effective management pin site infection pediatric supracondylar humerus fractures however excessive frequent care well pin care daily disadvantages child fear parental anxiety
realize goal environmental sustainability improving energy efficiency buildings major priority worldwide however practical design green building envelopes energy conservation highly complex optimization problem architects must make multiobjective decisions practice methods multicriteria analyses entail capitalizing possibly many nearly case limited alternatives commonly employed study investigated feasibility applying multiobjective optimal model building envelope design mopbem involved integrating building envelope energy performance model multiobjective optimizer mopbem established provide reference green designs nondominated sorting genetic algorithm nsga used achieve tradeoff design set three conflicting objectives namely minimizing envelope construction cost envcost minimizing envelope energy performance envload maximizing window opening rate wopr real office building case designed using mopbem identify potential strengths weaknesses proposed mopbem results showed high envcost expended simultaneously satisfying low envload high wopr various designs exhibited obvious cost reductions compared original architects manual design demonstrating practicability mopbem elsevier ltd rights reserved
celiac disease gluten triggered autoimmune disorder small intestine lifelong gluten free diet gfd approved treatment however strict adherence difficult many suffer inadvertent gluten exposure oral egg yolk anti gliadin antibody agy novel treatment neutralize gluten may improve efficacy gfd determine safety tolerability potential efficacy agy patients week open label single arm study conducted adults biopsy proven gfd safety measures included adverse events physical examination clinical laboratory tests additional measures included daily celiac symptom index health related quality life anti tissue transglutaminase anti gliadin iga igg lactulose mannitol excretion ratio lmer week run period assess questionnaire compliance acceptability baseline safety laboratory results followed week treatment period two agy capsules taken meals ten patients completed study mean age years nine female followed gfd least months mean years safety concerns identified patients fewer celiac symptoms especially tiredness headache bloating improved quality life lowered antibodies lowered lmer taking agy compared run period cohort agy safe potentially associated improved related outcome measures patients gfd larger study powered safety efficacy evaluation planned
construction management process thought supply chain management used made great achievements brought many problems well instance contradiction reducing risk interruption reducing inventory costs order find balance point two situations paper introduces costs model emergency strategies construction enterprises optimizing model obtained optimal standby contract quantity optimal quantity safety stock result also shows possible high costs loss work stoppages high management costs standby supplier influence two different factors safety stock order quantity standby contract supply disruption therefore optimal safety stock optimal order quantity standby contract subject costs caused standby supplier management costs caused loss lockout
work presents general state space representation multi machine multi order power system model may used carry small signal stability assessments computational software coded matlab developed order find analyse solution arbitrary number synchronous generators network generator represented pre defined model model choice tailored fit available data generator software provisions conducting power flow solutions calculation initial state generators keep prior disturbance state space representation equivalent transfer function matrix system generated automatically eigenvalue analysis may carried using standard matlab functionality paper one tutorial nature order check sanity results given new software two text book networks examined results also compared generated using commercial industrial grade software elsevier inc rights reserved
essential design protocol allow sensor nodes attest trustworthiness mission critical applications based wireless sensor networks wsns however challenge evaluate trustworthiness without appropriate hardware support hence present hardware based remote attestation protocol tackle problem within wsns design sensor node equipped trusted platform module tpm plays role trusted anchor start formulation remote attestation security complete protocol single hop multi hop attestations demonstrated results show new protocol effective efficient secure
reasoning physical properties objects heaviness observing others actions toward important useful adapting environment study asked whether domestic dogs canis familiaris use human action infer physical property target objects experiment dogs watched experimenter opening two differently loaded swinging doors different corresponding degrees effort allowed open one doors dogs chose randomly two doors experiment gave new dogs test experiment giving experience opening doors already knew doors could either light heavy test dogs reliably chose light door results indicate dogs able infer physical characteristics objects latters movement caused human action inferential reasoning requires direct experience objects published elsevier
wireless big data significantly challenges current network management control architecture mathematical modeling techniques distributed algorithm design particular promising cognitive distributed ultra dense networks motivated idea divide conquer article first present multiple cognitive agent based divide conquer network management control architecture furthermore markovian game theoretic modeling framework proposed model state big data based decision making problem investigate various learning methodologies respect different kinds state information particular concentrate construction state space state transition computation convergence parallel learning technique work provides suitable network management architecture effective modeling tool various learning techniques wireless big data networks elsevier rights reserved
group identity may embodied typical extreme member attributes present research suggests individuals perceptions group identity prototype predict beliefs status hierarchy turn prevalence social undermining behavior across four studies using experimental field data find perceiving group prototype focused ideal rather central tendency associated greater levels perceived status dispersion social undermining perceived status dispersion mediates relationship members perception group prototype social undermining behavior also find social context specifically salient group achievement goals elicited intergroup competition common ingroup identity attenuates effect ideal prototypes perceived social undermining theoretical implications social identity status social undermining literatures discussed
large number electrical components used civil aircraft engines whose electrical circuits usually intricate complicated continuity resistance important parameter operating state electrical components electrical continuity fault serious impact reliability aircraft engine paper mathematical models electrical components established simulation made simulink analyze electrical continuity fault
paper give short overview esdr standard properties new general modular receiving platform presented adapted different standards design methodology implementation issues discussed advanced receiver module flexible reduces implementation time prototype receivers
armed forces society issue women contemporary armed forces united states nations include south african national defense force australian defense force issue contains collection nine papers reviewing current aspect women serving military since post vietnam war era also two review essays megan mackenzie book beyond band brothers military myth women fight overview changing laws expanding role women military provided introduction well summaries nine articles comments two book reviews mentioned
nail dystrophy heterogeneous skin condition subtypes associated autoimmune diseases particular psoriasis psoriatic arthritis report show tofacitinib novel therapy rheumatoid arthritis appears beneficial patients nail disease refractory conventional modes therapy
people reliably distinguish sex faces across age groups rates accuracy lower infants however likely lack pronounced sexually dimorphic features develop puberty given previous research shown perceivers categorize adult sex automatically wondered whether would extend faces infants sex less legible tested using semantic priming paradigm infant faces preceded categorization stereotypically male female names results showed participants categorized sex male names significantly faster following perceptions male versus female infant faces though female faces significantly facilitate processing female names asymmetry interference male female faces supports evidence male default conceptions sex among infants previously found adults individuals may therefore process sex automatically absence overt cues post pubertal sexually dimorphic features stereotypical clothing providing additional evidence depth flexibility social categorization
american educational system currently yields disappointing levels science technology engineering math stem engagement achievement among students one way remedy may increase children motivation stem early age study examined whether social cue part experimental minimal group increases stem engagement preschoolers year olds using within subjects design participants assigned group individual condition counterbalanced order worked math task spatial task children persisted longer placed pieces correctly reported higher self efficacy interested group stem task individual stem task addition conducted continuously cumulating meta analysis ccma combine results current experiment two previous experiments findings suggest incorporating nonacademic social factors group membership current stem curricula could effective way boost young children stem motivation
objective evaluate attitude toward contraceptive methods gynaecologists germany sole prescribers contraceptives methods anonymous questionnaire sent gynaecologists inquiring factors involved prescription contraceptives contraceptives preferred would recommend daughter one results response rate survey combined oral contraceptive coc commonly prescribed method followed levonorgestrel releasing intrauterine system lng ius vaginal ring progestin pill pop patch progestin injectables respondents would never prescribe patch would never prescribe hormonal implant would choose lng ius partner would opt coc vaginal ring concerning imaginary daughter would prefer coc ring lng ius first counselling session lasted min provision information occasion following visits min conclusion contraceptives prescribed german gynaecologists cocs followed lng ius vaginal ring pops spectrum contraceptives preferred personal use differed ways prescribed patients reasons discrepancy investigated
background aims gemini long term safety lts study continuing phase trial investigating safety efficacy vedolizumab alpha beta integrin antagonist ulcerative colitis crohn disease provide interim analysis efficacy patients methods patients gemini studies cohort vedolizumab naive patients received open label vedolizumab every weeks interim data collected may june clinical response remission evaluated using partial mayo scores health related quality life hrql assessed weeks cumulative treatment efficacy population results june efficacy population continuing treatment among patients responded vedolizumab induction data available remission weeks exposure weeks among patients withdrew every week vedolizumab maintenance gemini week increased dosing every weeks gemini lts resulted response remission rates respectively weeks increase respectively dose increase similar benefits demonstrated regardless prior tumour necrosis factor antagonist exposure durable benefits hrql also observed conclusions patients experienced clinical hrql improvements continued vedolizumab treatment increased dosing frequency every weeks beneficial patients loss response weekly dosing
background present fully articulated protocol hamilton rating scale depression ham including item scoring rules rater training procedures data management algorithm increase accuracy scores prior outcome analyses latter involves identifying potentially inaccurate scores interviews discrepancies two independent raters basis either scores point difference meeting threshold depression recurrence status long term treatment outcome public health significance discrepancies resolved assigning two new raters identifying items disagreement per algorithm reaching consensus accurate scores items methods methods applied clinical trial primary outcome structured interview guide hamilton rating scale depression seasonal affective disorder version sigh sad includes item ham items assessing atypical symptoms seasonally depressed adult patients enrolled interviewed time points across treatment year followup interval total completed interviews archived results inter rater reliability ranged iccs interviews met criteria rater discrepancy ham items depressed mood work activities middle insomnia hypochondriasis atypical items fatigability hypersomnia contributed discrepancies limitations generalizability beyond well trained experienced raters clinical trial unknown conclusions researchers might want consider adopting protocol part full clinicians might want tailor needs elsevier rights reserved
people either knight spy known least knights present knights always tell truth consider spies always lie spies answer see fit paper determines minimum number questions required find spy prove everyone room knight also determine minimum number questions needed find least one person identity nominated person identity find spy assumption spy present spies alwaysiie prove searching problems problem finding knight solved simultaneous optimal strategy also give computational results problem finding identities spies always lie show plausible suggestion made aigner false end stating open problems questioning strategies paper applications fault finding distributed computing networks elsevier rights reserved
previous studies measuring high direct voltage focused resistive voltage divider hall voltage sensor cost hall voltage sensor expensive additional shielding method must taken account using voltage divider paper resistive voltage divider integrated operational amplifiers photocouplers used cooperatively design voltage measurement circuit two photocouplers used together current transfer ratio ctr balance reduce influences high input direct voltage low output direct voltage ratio experimental results carefully setting offset gain calibration values show measurement circuit get good measurement accuracy low cost solar energy system
polyurethane dish washing sponges functionalized sequentially polyethylenimine pei graphene oxide form pei reduced graphene oxide rgo sponges pei rgo sponge consists pei rgo sheets numerous pores diameters ranging enhance hydrophobicity absorption capacity oil pei rgo sponge coated phenyltrimethoxysilane ptmos ptmos pei rgo sponge absorbs various oils within maximum absorption capacity values bicycle chain oil motorcycle engine oil respectively absorbed oils released completely squeezing immersed hexane ptmos pei rgo sponge efficiently separates oil water mixtures flowing system advantages faster absorption rate reusability low cost ptmos pei rgo sponge holds great potential superabsorbent efficient removal recovery oil spills well separation oil water mixtures elsevier ltd rights reserved
objectives mobiguide project aimed establish ubiquitous user friendly patient centered mobile decision support system patients care providers based continuous application clinical guidelines semantically integrated electronic health records patients would empowered system would enable lead normal daily lives regular environment feeling safe health state would continuously monitored using mobile sensors self reporting symptoms conditions occur require medical attention patients would notified need based evidence based guidelines medical team would informed appropriately parallel wanted assess system feasibility potential effects patients care providers two different clinical domains materials methods describe mobiguide architecture embodies objectives novel methodologies include ubiquitous architecture encompassing knowledge elicitation process parallel coordinated workflows patients care providers customization computer interpretable guidelines cigs secondary contexts affecting remote management distributed decision making mechanism episodic demand projection relevant portions cigs centralized backend decision support system dss local mobile dss continuously delivers actual recommendations patient shared decision making embodies patient preferences semantic data integration patient care provider notification services mobiguide implemented assessed preliminary fashion two domains atrial fibrillation gestational diabetes mellitus gdm ten patients used mobiguide system italy gdm patients used gdm mobiguide system spain evaluation mobiguide system focused patient care providers compliance cig recommendations satisfaction quality life results evaluation demonstrated system capability supporting distributed decision making use patients clinicians results show compliance gdm patients important monitoring targets blood glucose levels performance four measurements day measurement according recommended frequency every day twice week ketonuria blood pressure high gdm patients compliance patients important targets quite high considering required ecg measurements blood pressure measurements outcome viewed clinicians major potential benefit system patients demonstrated capable self monitoring something experienced addition system caused clinicians managing patients change diagnosis subsequent treatment two ten patients caused clinicians managing gdm patients start insulin therapy earlier two patients based system recommendations based end study questionnaires sense safety system provided patients greatest asset analysis patients quality life qol questionnaires patients inconclusive patients reported improvement quality life euroqol questionnaire patients reported deterioration afeqt questionnaire discussion feasibility potential benefits evidence based distributed patient guidance system demonstrated clinical domains potential application mobiguide medical domains supported standards based patient health record multiple electronic medical record linking capabilities generic data insertion methods generic medical knowledge representation application methods ability communicate wide range sensors future larger scale evaluations assess impact system clinical outcomes conclusion mobiguide feasibility demonstrated working prototype gdm domains usable patients clinicians achieving high compliance self measurement recommendations enhancing satisfaction patients care providers elsevier rights reserved
perceived criticism construct plays key role family relationships persons psychiatric disorders assessed brief simple way using perceived criticism measure ratings made patients caregivers predict adverse clinical outcomes including increases symptoms relapse across broad range psychiatric diagnoses although research supports concurrent predictive validity measure widely used clinical practice describe construct review evidence supporting clinical utility illustrate criticism perceptions criticism addressed clinical context describing family focused treatment approach used depressed adolescent high risk bipolar disorder wiley periodicals inc
dysfunction brain derived arginine vasopressin avp systems may involved etiology autism spectrum disorder asd certain regions hypothalamus amygdala hippocampus known contain either avp neurons terminals may play important role regulating complex social behaviors present study designed investigate concomitant changes autistic behaviors circulating avp levels structure functional connectivity specific brain regions autistic children compared typically developing children tdc aged years results showed children asd significantly increased volume left amygdala left hippocampus significantly decreased volume bilateral hypothalamus compared tdc positively correlated plasma avp level autistic children negative left amygdala bilateral supramarginal gyri compared tdc degree negative amygdala supramarginal gyrus associated higher score clinical autism behavior checklist degree negative left amygdala left supramarginal gyrus associated lowering circulating avp concentration boys asd autistic children showed higher left hippocampus right subcortical area compared tdc circulating avp negatively correlated visual listening response score childhood autism rating scale results strongly suggest changes structure brain regions containing avp may involved etiology autism
despite studies exploring potential applications unmanned aerial systems uass particular use value visual assets photographs video collected uass construction management tasks well understood paper presents exploratory case study identify potential applications visual assets obtained uass construction management tasks case study involved development visual assets database uas based images videos collected uas flights jobsites united states brazil well semi structured interviews construction project personnel results revealed potential applications uass mainly project progress monitoring job site logistics evaluating safety conditions quality inspections among secondary management tasks addition analysis costs related use uass performed main contribution case study better understanding use uass construction management tasks regulatory cost implications
chaste open source library computational biology well developed cardiac electrophysiology tissue simulation support paper introduce features available performing cardiac electrophysiology action potential simulations using wide range models physiome repository mathematics models described ceiiml units quantities primary idea model defined one place ceiiml file model code auto generated compile run time never manually edited use ontological annotation identify model variables describing certain biological quantities membrane voltage capacitance etc allow import relevant celiml models chaste framework consistent units interact via consistent interfaces approach provides great deal flexibility analysing different models system chaste provides wide choice numerical methods solving ordinary differential equations describe models fixed timestep explicit implicit solvers provided discussed previous work introduce rush larsen generalized rush larsen integration techniques made available via symbolic manipulation model equations automatically rearranged forms required approaches also integrated cvode solvers gold standard stiff systems developed support symbolic computation jacobian matrix yielding increases performance accuracy cvode discuss technical details work compare performance available numerical methods finally discuss generalized functional curation framework uses domain specific language defining complex experiments basis comparison model behavior
background onset bipolar disorder influenced interaction genetic environmental factors previously found large increase sunlight springtime associated lower age onset study extends analysis collection sites diverse locations includes family history polarity first episode methods data patients bipolar disorder collected collection sites countries latitudes spanning north south equator age onset first episode onset location family history mood disorders polarity first episode obtained retrospectively patient records direct interview solar insolation data obtained onset locations results large significant inverse relationship maximum monthly increase solar insolation age onset controlling country median age birth cohort effect reduced half family history maximum monthly increase solar insolation occurred springtime effect one third smaller initial episodes mania depression largest maximum monthly increase solar insolation occurred northern latitudes oslo norway warm dry areas los angeles california limitations recall bias onset family history data conclusions large springtime increase sunlight may important influence onset bipolar disorder especially family history mood disorders elsevier rights reserved
consider simple random walks random graphs embedded generated point processes delaunay triangulations gabriel graphs creek crossing graphs suitable assumptions point process show annealed invariance principle random walks results hold large variety point processes including poisson point processes matern cluster matern hardcore processes respectively clustering repulsiveness properties proof relies use process environment seen particle allows reconstruct original process additive functional markovian process annealed measure
parent training delivered guided self help intervention may cost time effective intervention treatment children externalizing disorders face face parenting strategies repeatedly identified mediating mechanisms decrease children problem behavior studies examined possible mediating effects guided self help interventions parents present study aimed investigate possible mediating variables behaviorally oriented guided self help program parents children externalizing problems compared nondirective intervention clinical sample sample parents children externalizing disorders boys randomized either behaviorally oriented nondirective guided self help program four putative mediating variables examined simultaneously multiple mediation model using structural equation modelling outcomes child symptoms adhd odd well child externalizing problems assessed posttreatment analyses showed significant indirect effect dysfunctional parental attributions favor group receiving behavioral program significant effects behavioral program positive negative parenting parental self efficacy compared nondirective intervention results indicate decrease dysfunctional parental attributions leads decrease child externalizing problems parents take part behaviorally oriented guided self help program however none putative mediating variables could explain decrease child externalizing behavior problems nondirective group change dysfunctional parental attributions considered possible mediator context
aim paper report study factors affect turnover newly licensed registered nurses united states hospitals background large body research related nursing retention however little information specific newly licensed registered nurse turnover incidence rates turnover among new nurses unknown turnover data nationally representative samples nurses method study used longitudinal panel design obtain data registered nurses recently licensed examination first time mailed surveys nationally representative sample hospital registered nurses year apart analytic sample consisted nurses responded survey mailings january results full time employment sprains strains including back injuries result turnover higher intent stay hours voluntary overtime one job pay reduces turnover omitted intent stay probit model less job satisfaction organizational commitment led turnover confirming importance turnover magnet recognition award hospitals several work attributes effect turnover conclusion turnover problems complex means one solution decreasing turnover multiple points intervention exist one specific approach may improve turnover rates hospital policies reduce strains sprains
calcium activated chloride channels involved several physiological processes including olfactory perception tmema tmemb members transmembrane protein family tmem responsible calcium activated chloride currents several cells present olfactory epithelium adult mice little known expression embryonic development using immunohistochemistry studied expression mouse olfactory epithelium various stages prenatal development embryonic day well postnatal mice tmema immunoreactivity present apical surface entire olfactory epithelium became restricted region near transition zone respiratory epithelium localized apical part supporting cells microvilli contrast tmemb immunoreactivity present apical surface entire olfactory epithelium increased subsequent days localized cilia mature olfactory sensory neurons data suggest different functional roles tmema tmemb developing well postnatal olfactory epithelium presence tmema apical part microvilli supporting cells consistent role regulation chloride ionic composition mucus covering apical surface olfactory epithelium whereas localization tmemb cilia mature olfactory sensory neurons consistent role olfactory signal transduction wiley periodicals inc
power quality major concern relatively small island electrical network new zealand potential influx new technologies electric vehicles heat pumps light emitting diode lighting etc could potentially cause electromagnetic compatibility problems future manage future government funded project entitled power quality future electricity networks instigated project funded electricity engineers association eea main deliverable guidelines eea members could adopt grid connection codes objectives influence device standards identify mitigation techniques paper gives overview project presents key findings
aging cause cognitive decline elderly major risk factor alzheimer disease however aging people destined develop cognitive deficits molecular mechanisms underlying difference cognition aging people obscure epigenetic modifications particularly histone acetylation nervous system play critical role regulation gene expression learning memory inhibitor acetyltransferases inhat reported suppress histone acetylation via histone masking mechanism key component inhat complex present study divided old aged mice cognitive normal cognitive impaired group morris water maze found level significantly increased hippocampus cognitive impaired aged mice mrna protein levels synaptic associated proteins decreased reduced dendrite complexity histone acetylation knockdown rescued cognitive decline cognitive impaired aged mice restoration synaptic associated proteins increase spine density elevation histone acetylation study reveals novel mechanism underlying aging associated cognitive disturbance indicating suppression might represent promising therapeutic approach learning memory impairments
paper looks benefits applying quaternions study research electrical circuits motor generator applications bottom approach taken paper shows variables electrical circuits formulated vector quantities simple manipulation variables give results easily interpreted especially variables quadrature one another example force calculation electrical motors also developed extended case non ideal flux rotor coil positioning applications quaternions eluded completeness
dietary selenium deficiency cause heart dysfunction however exact mechanism remains unclear understand mechanism day old chicks divided two groups control group low group fed either sufficient deficient diets days respectively heart tissues blood samples collected group activities serum creatine kinase creatine kinase myoglobin increased typical ultrastructural apoptotic features observed deficiency regulated mrna levels cysteinyl aspartate specific proteinase caspase cysteinyl aspartate specific proteinase caspase cysteinyl aspartate specific proteinase caspase cell lymphoma leukemia bcl bcl associated protein bax whereas mrna levels microtubuleassociated protein light chains autophagy associated gene atg mammalian target rapamycin mtor dynein becline regulated noticeably microtubuleassociated protein light chains mrna level increased western blot results showed deficiency decreased expression becline protein however expression bax caspase cysteinyl aspartate specific proteinase caspase increased protein levels present study revealed deficiency induced apoptosis inhibited autophagy chicken cardiomyocytes bax bcl inhibition caspases mediated cleavage becline moreover correlation analysis illustrates apoptosis autophagy might function contradictorily altogether conclude deficient chicken cardiomyocytes experienced apoptosis rather autophagy considered pro survival elsevier inc rights reserved
purpose review article discusses promising agents approved currently investigation treatment myelofibrosis reviews ongoing janus kinase jak inhibitors based combinatorial strategies setting recent findings myelofibrosis philadelphia negative myeloproliferative neoplasm constitutive jak stat activation jak inhibitor ruxolitinib approved drug disease united states europe based two randomized phase iii studies demonstrated clinically meaningful reduction spleen size improvement symptoms quality life overall survival advantage prolonged follow emerging data revealed complex molecular architecture myelofibrosis clonal evolution playing central role disease progression transformation molecular pathways may explain heterogeneous benefits obtained jak inhibitors patients myelofibrosis addition genetic epigenetic mutations appear work concert overactive jak stat signaling contribute myelofibrosis pathogenesis prognosis suggesting potential exploit potential therapeutic targets summary combining jak inhibitors agents target parallel prosurvival pathways agents enhance hematopoiesis may enhance efficacy mitigate target myelosuppression thereby extending therapeutic benefits observed jak inhibitors alone
psychological literature indicates people mood affects choices judgments find short trading days around holidays tel aviv stock exchange accompanied positive abnormal returns reduced volatility returns anomaly evident main stock indices well economic sector indices anomaly seems size related small mid cap indices producing abnormal returns addition volatility index vix short trading days tends lower normal trading days findings suggest investors benefit using two simple trading strategies elsevier rights reserved
using several proxies seasonal affective disorder sad find sad negatively affects initial public offering ipo first trading day return underpricing periods periods periods sad affects ipo underpricing firm exposure mitigates negative effect sad addition years find negative effect sad offer price revision ipo bookbuilding suggests premarket investors adjust sad effects bookbuilding process
bromodomain phd finger containing protein brpf unique epigenetic regulator contains multiple structural domains recognizing different chromatin modifications addition possesses sequence motifs forming multiple complexes three different histone acetyltransferases moz morf hbo within complexes brpf serves scaffold bridging subunit interaction stimulating acetyltransferase activity governing substrate specificity stimulating gene expression investigate molecular interactions extrapolated biological functions brpf utilized mouse strain containing knock reporter analyzed spatiotemporal expression embryos adults analysis revealed dynamic expression extraembryonic embryonic fetal tissues suggesting important roles brpf prenatal development support inactivation mouse brpf gene causes lethality around embryonic day birth high expression present testis specific regions brain dimensional expression atlas mouse brpf serve valuable guide analyzing interaction moz morf hbo vivo well investigating whether brpf functions independently three enzymatic epigenetic regulators
identification allergen epitopes key component proper understanding pathogenesis type allergies understanding cross reactivity development mimotope immunotherapeutics phage particles garnered recognition field molecular allergology due value competitive immunoscreening peptide libraries also immunogenic carriers allergen mimotopes integrate epitope discovery technology immunization functions single platform article provides overview allergen mimotopes identified phage display technique discuss contribution phage display peptide libraries determining dominant cell epitopes allergens developing mimotope immunotherapy understanding cross reactivity determining ige epitope profiles individual patients improve diagnostics individualize immunotherapy also discuss advantages pitfalls methodology used identify validate mimotopes
implant failure common problem orthopedic applications causes pain stress patients prolonged antibiotic therapy increased time cost hospitalization revision surgery selecting optimum porous structure manufacturing process surface modification approach crucial reduce rate implant failure design porous structures orthopedic implants plays important role vascularization diffusion nutrients relationship implants osteoblasts common techniques porous design computer aided design cad image based design implicit surface design topology optimization metal based additive manufacturing methods electron beam melting ebm selective laser melting slm selective laser sintering sls extensively developed fabrication porous structures titanium several chemical surface modification methods used acid etching anodization coatings improve mechanical properties biocompatibility increase surface roughness promote osseointegration bone regrowth paper reviews design manufacturing porous implant material via additive manufacturing techniques well recent advances surface modification achieve biocompatible surfaces outcome research provide effective strategy manufacturing surface modification titanium orthopedic implants authors published elsevier ltd
background aims concurrent development effective drugs treatment hepatitis virus hcv infection increase incidence nonalcoholic fatty liver disease data indicate liver transplantation prolongs survival times patient acute hepatitis associated alcoholic liver disease ald compared data disease prevalence population data liver transplantation waitlists evaluate changes burden liver disease united states methods wecollected data prevalence hcv cycles national health andnutrition examination survey wealso collected data fromthe healthcore integrated research database patients cirrhosis chronic liver failure clf data patients received transplants united network organ sharing determined percentages new waitlist members transplant recipients hcv infection stratified indication transplantation modeling calendar year continuous variable using spearman rank correlation nonparametric test trends linear regression models results analysis data national health nutrition examination survey found proportion patients positive hcv antibody positive hcv rna confidence interval valuewas significantly lower confidence interval data healthcore database revealed significant changes time percentages patients compensated cirrhosis decreases percentages patients cirrhosis fromhcv ald increase percentages patients cirrhosis nonalcoholic steatohepatitis nash clf decreases percentages patients clf hcv ald almost fold increase percentage patients clf nash hepatocellular carcinoma hcc decreases percentages patients hcc hcv ald small increase hcc among persons nash data fromthe united network organ sharing revealed among patients new liver transplant waitlist undergoing liver transplantation clf significant decrease percentage hcv infection increases percentages patients nonalcoholic fatty liver disease ald among patients newto liver transplant waitlist undergoing liver transplantation hcc proportions hcv infection nonalcoholic fatty liver disease ald change conclusions analysis different databases national health nutrition examination survey healthcore united network organ sharing found proportion patients liver transplant waitlist undergoing liver transplantation chronic hcv infection decreasing fewer patients cirrhosis clf however percentages patients waitlist receiving liver transplants nash ald increasing despite different relative burdens disease among entire population patients cirrhosis
background dioscin shown cytotoxicity cancer cells poor solubility stability limited clinical application study designed mixed micelles composed tpgs soluplus copolymers entrapping poorly soluble anticancer drug dioscin method order improve aqueous solubility bioactivity dioscin tpgs soluplus mixed micelles optimal ratio prepared using thin film hydration method physicochemical properties characterized cellular cytotoxicity uptake dioscin loaded tpgs soluplus mixed micelles studied mcf breast cancer cells ovarian cancer cells pharmacokinetics free dioscin dioscin loaded tpgs soluplus mixed micelles studied vivo male sprague dawley rats via single intravenous injection tail vein results average size optimized mixed micelle drug encapsulation efficiency drug loading efficiency vitro release profile showed mixed micelles presented sustained release behavior compared anhydrous ethanol solution dioscin vitro cytotoxicity assays conducted human cancer cell lines including ovarian cancer cells mcf breast cancer cells mixed micelles exhibited better antitumor activity compared free dioscin cell lines may benefit significant increase cellular uptake dioscin mixed micelles compared free dioscin pharmacokinetic study showed mixed micelle formulation achieved times longer mean residual time mrt circulation times larger area plasma concentration time curve auc free dioscin solution conclusion results suggest dioscin loaded mixed micelles developed study might potential nano drug delivery system cancer chemotherapy
paper considers two stage capacitated facility location problem tscflp products manufactured plants delivered customers via storage depots customer demands satisfied subject limited plant production limited depot storage capacity objective determine locations plants depots order minimize total cost including fixed cost transportation cost however problem known hard practicable exact algorithm impossible developed order solve large sized problems encountered practical decision process efficient alternative approximate method becomes valuable paper aims propose hybrid evolutionary algorithm framework machine learning fitness approximation delivering better solutions reasonable amount computational time study genetic operators adopted perform search process local search strategy used refine best solution found population avoid expensive consumption computational time fitness evaluating process framework uses extreme machine learning approximate fitness individuals moreover two heuristics based characteristics problem incorporated generate good initial population computational experiments performed two sets test instances recent literature performance proposed algorithm evaluated analyzed compared algorithms literature proposed algorithm find optimal near optimal solutions reasonable amount computational time employing proposed algorithm facilities positioned efficiently means fixed cost transportation cost decreased significantly organizations enhance competitiveness using optimized facility location scheme elsevier ltd rights reserved
using total segmented sections reconstructed three dimensional structure pure iron obtained largest dataset complete grains reported date mean values equivalent sphere radius face number pure iron observed consistent monte carlo simulated grains phase field simulated grains alloy grains based super alloy grains work finding balance automatic methods manual refinement developed interactive segmentation method segment serial sections accurately reconstruction microstructure approach save time well substantially eliminate errors segmentation process comprises four operations image preprocessing breakpoint detection based mathematical morphology analysis optimized automatic connection breakpoints manual refinement artificial evaluation
lot research done improve fatigue strength materials creating compressive residual stress field surface layers shot peening paper fatigue strength shot peened leaf springs calculated laboratory samples axial fatigue strength ena spring steel specimen evaluated experimentally function shot peening conditions used full scale leaf springs testing industries optimum shot peening condition specimen found sin curves specimens correlated leaf springs curve mathematical model developed predicts fatigue life leaf springs given stress varying shot peening conditions predictions model compared experimental data estimation fatigue life relaxation compressive residual stress field discussed elsevier ltd rights reserved
cancer immune checkpoint therapy achieved remarkable clinical successes various cancers however current immune checkpoint inhibitors block checkpoint immune cells important canter therapy also immune cells irrelevant therapy indiscriminate blockade limits efficacy causes autoimmune toxicity therapy might beneficial use carrier target immune checkpoint inhibitors cancer reactive immune cells explore method load inhibitors carriers used anti programmed death antibody alpha model immune checkpoint inhibitor first generated recombinant single chain variable fragment scfv apd designed generated fusion protein consisting scfv amphiphilic immune tolerant elastin like polypeptide itep amphiphilic itep fusion able self assemble nanoparticle proved block immune checkpoint vitro vivo particularly exacerbated diabetes development nonobese diabetic mice effectively natural intact apd summary successfully expressed apd recombinant protein linked apd lays foundation develop delivery system target apd subpopulation immune cells
janus kinase jak family non receptor protein tyrosine kinases consists jak jak jak tyk tyrosine kinase proteins contains jak homology pseudokinase domain regulates adjacent protein kinase domain jak tyk ubiquitously expressed whereas jak found predominantly hematopoietic cells janus kinase family regulated numerous cytokines including interleukins interferons hormones erythropoietin thrombopoietin growth hormone ligand binding cytokine hormone receptors leads activation associated janus kinases mediate phosphorylation receptors domain stats signal transducers activators transcription binds receptor phosphotyrosines thereby promoting stat phosphorylation janus kinases consequent activation stat dimers translocated nucleus participate regulation expression thousands proteins jak stat dysregulation results autoimmune disorders rheumatoid arthritis ulcerative colitis crohn disease jak stat dysregulation also plays role pathogenesis myelofibrosis polycythemia vera myeloproliferative illnesses activating jak mutation occurs people polycythemia vera lower percentage people neoplasms jak signaling participates pathogenesis inflammatory afflictions jak signaling participates development several malignancies including leukemias lymphomas well myeloproliferative neoplasms tofacitinib pan jak inhibitor approved fda treatment rheumatoid arthritis ruxolitinib jak inhibitor approved treatment polycythemia vera myelofibrosis elsevier ltd rights reserved
small scale thermoacoustic stirling engine tashe simulated according linear thermoacoustic theory computed results show small scale thermoacoustic stirling heat engine diameter resonance tube might important influences working frequency performance engine always neglected large scale system likewise analysis experimental results show order obtain better engine performance diameter resonance tube must chosen appropriately according looped tube dimension input heating power provides effective way miniaturize thermoacoustic stirling heat engine according computation analysis small scale engine built resonance tube length diameter respectively working frequency input heating power maximal peak peak pressure amplitude pressure ratio reached mpa respectively able drive thermoacoustic refrigerator electrical generator
polysaccharides beta glucan configuration well known antioxidant activity reactive free radicals generated oxidation metabolic processes study beta glucan polysaccharides extracted ganoderma lucidum incorporated palm olein based nanoemulsions act carrier systems enhance delivery bioactivity polysaccharides could potentially useful skin care applications initially response surface statistical design central composite design ccd subjected optimize formulation variables oil water nanoemulsions induced ultrasound optimal formulation variables predicted ccd resulted considerably improving physical characteristics ultrasonically formulated nanoemulsions minimizing droplet size polydispersity index viscosity moreover beta glucan loaded nanoemulsions exhibited good stability days different storage conditions degrees degrees studies using palm olein based beta glucan loaded nanoemulsion generated using ultrasound confirm higher antioxidant activity compared free beta glucan elsevier rights reserved
background bisulfite treatment dna followed sequencing seq become standard technique epigenetic studies providing researchers tools generating single base resolution maps whole methylomes aligning bisulfite treated reads however computationally difficult task bisulfite treatment decreases lexical complexity low methylated genomic regions mismatches may reflect cytosine unmethylation rather snps sequencing errors challenges arise alignment phase data structures used aligner fast fit main memory methylation caller output somehow compressed due significant size methods far data structures employed align bisulfite treated reads concerned solutions proposed literature roughly grouped two main categories storing pointers text position hash tables suffix trees arrays using information theoretic minimum number bits indexes compressed suffix arrays former fast memory consuming latter much slower light paper try close gap proposing data structure aligning bisulfite treated reads time fast light accurate reach objective combining recent theoretical result succinct hashing bisulfite aware hash function furthermore new versions tools implementing ideasithe aligner erne caller erne meth extended increased downstream compatibility epp bismark coy output formats output compression support target enrichment protocols results experimental results public simulated wgbs libraries show algorithmic solution competitive tradeoff hash based bwt based indexes fast accurate former memory efficient latter conclusions new functionalities bisulfite aligner caller make fast memory efficient tool useful analyze big datasets little computational resources easily process target enrichment data produce statistics protocol efficiency coverage function distance target regions
since ancient times mediterranean island sardinia known harboring population average body height shorter almost every ethnic group europe century investigations cause origin uniqueness yet clear shorter stature sardinians appears documented since prehistoric times revealed analysis skeletal remains discovered archaeological sites island recently number genetic hormonal environmental infective nutritional factors put forward explain unique anthropometric feature persisted long time even environmental living conditions improved around although putative factors supported sound empirical evidence weaker support available others recent advent whole genome analysis techniques shed new light specific variants origin short stature however marked geographical variability stature across time space within island well known presence pockets short height population southern districts still puzzling findings attracted interest anthropologists geneticists purpose review focus state art research stature well factors made sardinians shortest among europeans
background insulin resistance previously associated increased risk developing alzheimer disease although relationship yet clear examined influence using plasma cerebrospinal fluid csf biomarkers related cognitively healthy men also aimed characterise shared protein signatures methods fifty eight cognitively healthy men non age apoe epsilon matched drawn metabolic syndrome men study kuopio finland csf biomarkers amyloid beta peptide beta total tau tau phosphorylated thr epitope examined respect targeted proteomics using elisa luminex xmap assays performed assess influence previously identified csf plasma protein biomarker candidates pathology furthermore csf plasma somascan performed discover proteins associate csf biomarkers results csf biomarkers differ non groups although plasma insulin correlated csf beta tau across whole cohort total csf plasma proteins differentially expressed non subjects significantly enriched pathways many previously implicated identified csf plasma proteins significantly associated csf biomarkers also discovered sensitive identified conclusions data indicate directly related level csf pathology cognitively healthy men proteins associated potential markers indicative shared pathology
article presents automatic generation control agc interconnected two area hybrid thermal system additional power generation dish stirling solar thermal system dsts wind turbine system wts area equipped integral proportional integral proportional integral derivative pid secondary controllers regulate power output thermal system maintain power balance facilitates maintaining frequency close nominal value biogeography based optimization bbo technique used simultaneous optimization controller parameters system dynamics evaluated step load perturbation random load perturbation area performance pid found improved comparison controller terms settling time peak deviation magnitude oscillation investigation shows bbo optimized pid controller parameters obtained nominal conditions robust enough necessary optimize wide changes renewable energy sources area capacity ratio system loading inertia constant thus integration dsts wts agc interconnected system safely attributed elsevier ltd rights reserved
paper prove existence regularity solution two dimensional system evolutionary hemivariational inequalities describes boussinesq model nonmonotone friction heat flux use time retardation regularization technique combined regularized galerkin method recent results theory hemivariational inequalities elsevier ltd rights reserved
setting relational databases schema database provides context data interpreted consequence quality relational database depends strongly assumption data fits context description paper investigate case information provided attribute value exceeds framework provided schema shown information overflow two orthogonal causes data multiple attributes jointly stored one attribute data multiple tuples jointly stored one tuple needless say erroneous information storage deteriorates quality database paper investigated data quality improved split operator major difficulty hereby take account constraints present relational database generic algorithm provided tested well know cora dataset
article analyze different teaching learning situations identified primary secondary schools delivering inquiry based computer programming classes specifically work data obtained two years team offered teacher proffesional development course teaching computer programming data includes pre post teachers survey participated course transfered learned professional development classrooms tutor computer science advance students attended lessons supported teachers implementation teaching programming observed recorded lessons triangulated classroom observations pre post teacher survery identified different experiences introducing teaching computer programming schools identified four situations along two years situations challenge traditional structure formal schooling
although schistosoma species trypanosoma cruzi share common endemic areas infections parasites remains overlooked using murine model mansoni cruzi infection investigated extent infections might interact change pathological outcomes typically observed host infected single parasite species swiss mice randomized four groups uninfected infected mansoni cruzi infected days mansoni infection cruzi concurrently inoculated infection occurred days taken together identified overlap schistosomiasis chagas disease immunological patterns changes host resistance pathogens beyond impairing control granulomatous inflammation cruzi parasitemia parasitism infected animals inflammatory response mansoni elicits activation arginase pathway detriment inducible oxide nitric synthase inos expression nitric oxide production contributing liver damage minor effects heart pathology elsevier inc rights reserved
three party scheme secure quantum communication namely controlled quantum dialogue cqd analyzed influence non markovian channels comparing corresponding markovian cases seen average fidelity maintained relatively longer periods time interestingly number facets quantum cryptography quantum secure direct communication deterministic secure quantum communication controlled counterparts quantum dialogue quantum key distribution quantum key agreement reduced cqd scheme therefore cqd scheme analyzed influence damping dephasing depolarizing non markovian channels subsequently effect non markovian channels schemes secure quantum communication deduced results obtained cqd damped non markovian channel causes periodic revival fidelity fidelity observed sustained influence dephasing non markovian channel
ability tram detecting parametric faults second order filter selected case study studied work particularly adopt low pass sallen key filter synthesized cmos technology perform design using diffused resistors poly poly capacitors full custom operational amplifier fault injection simulation adopt previously reported fault model different combinations test parameters evaluated paper aim determining tradeoff fault coverage complexity test results show simultaneous monitoring peak time overshoot gives reasonable fault coverage monitoring test parameters causes cases improvement considered marginal
non linear load deteriorates quality current waveforms point common coupling various consumers active power filter apfs used mitigate concern harmonic pollution electrical network controller part nucleus active power filter configuration active power filter performance affected significantly selection current control techniques active filter current control must capability track sudden slope variations current reference compensate distorted current drawn voltage source inverter therefore choice implementation current regulator important achievement satisfactory performance level survey technical reviews various types controllers covering wide range presented work also reveals advantages disadvantages practiced control strategies effectiveness study help researchers choose proper control methods various applications active power filter
information web increasingly retrieved relational databases query language based exact matching data fulfil completely query results returned user contain tuples satisfy conditions query thereby user confronted problem empty answers case selective query overcome problem several approaches proposed literature particularly based query conditions relaxation others works suggest use fuzzy sets theory introduce flexible queries another line research proposes adaptation information retrieval approaches get approximate matching databases discuss paper adaptation language model deal empty answers main idea behind approach instead returning empty response user ranked list tuples similar values specified user query returned
bioinformatics grown quickly last years grow even faster future one long standing open challenges bioinformatics biomarker identification cancer diagnosis gene expression paper authors propose novel hybrid wrapper filter feature selection approach identify informative genes cancer diagnosis named hwf handles selection two steps first one iterative filter based mechanism generate potential subsets genes second step aggregation best selected subsets means wrapper based consensus process relies particle swarm optimization adapted feature selection ensemble classifiers svm knn employed evaluate selected genes experiments nine publicly available cancer dna microarray datasets shown hwf selects robust signatures high classification accuracy competes even outperforms methods literature
background objective facial dermatitis common roles different exogenous factors play facial nonfacial dermatitis unknown study aim investigate etiology self reported exogenous aggravation factors facial dermatitis methods facial dermatitis patients patch tested tertiary hospital year period patients nonfacial dermatitis tested period served control association exogenous factors investigated multivariate analyses results cases facial dermatitis confirmed allergic contact dermatitis higher controls cosmetic allergy much common facial nonfacial allergic contact dermatitis facial allergic contact dermatitis cases caused facial creams facial dermatitis irritant contact dermatitis compared controls cases seasonal facial dermatitis positive patch test reactions least one standard allergen facial dermatitis controls self reported exogenous aggravation factors facial dermatitis spicy food ingestion low moisture sunlight alcohol ingestion seafood ingestion beef lamb ingestion high humidity multivariate logistic regression analysis adjusting sex age disease duration atopic diathesis contact allergy showed patients reported aggravation sunlight exposure ingestion spicy food alcohol conclusions contact factors play important role facial dermatitis aggravation sunlight exposure ingestion spicy food alcohol reported facial dermatitis compared nonfacial dermatitis copyright taiwanese dermatological association published elsevier taiwan llc
objectives specify epidemioclinical legal aspects sexual abuse among minors evaluate cost care dakar materials methods retrospective multicenter cross sectional study sexual abuse among minors period four years january december four maternities targeted social hygiene institute medina health center roi baudouin guediawaye pikine hospital health center youssou mbargane diop rufisque results study period child victims sexual abuse supported four health facilities total sexual abuses ages frequency epidemiological profile patients child years old average female living suburbs dakar children often abused working hours outside family environment often someone known victim genito genital contact common mode sexual contact vaginal penetration cases almost victims came consult accompanied parents day sexual abuse examination usually revealed hymenal trauma nearly half consisted old lesions victims post traumatic stress disorder mutism recorded six pregnancies sample case hiv infection recorded sample taken hours sexual abuse control three months hiv serology requested cases children received antiretroviral prophylaxis antibiotic prophylaxis performed cases using doxycycline drug choice patients received emergency contraception progestin psychological care concerned children legal aspects patients filed complaint prosecutions convicted acquitted rate court settlement time limit settlement justice average months extremes one month months average cost care estimated cfa francs euros taking account consumables used clinical examination sterile gloves catheter syringe analysis prescription drugs conclusion sexual abuse minors disturbing reality raises rightly universal reprobation senegal mainly affects children magnitude increasing years improved support victims necessarily involves raising public awareness media development specialized structures management sexual abuse elsevier masson sas rights reserved
introduction restoration native head shaft angle hsa critical treatment proximal humerus fracture however hsa properly investigated according humeral rotation study designed analyze relationship humeral rotation hsa increments clarify serial changing pattern according humeral rotation hypothesis angulation hsa would undervalued humerus rotated externally would overvalued rotated internally materials methods eight dried cadaveric normal humeri scanned analyzed using computer aided design standardized neutral position hsa angle humeral shaft axis humeral head axis best fit lines center best fitting circles every cross section along humeral shaft within humeral head respectively model rotated degrees internally degrees externally relatives degrees increments camera fixed antero posterior view neutral position angulation hsa every rotational degree documented ratio relatives angulation hsa neutral position results average hsa neutral position degrees hsa underestimated overestimated maximum external rotation internal rotation respectively hsa underestimated every degrees overestimated every degrees rotational misalignments within degrees degrees could tolerated conclusions hsa underestimated overestimated information could useful surgeons restoring native hsa treatment proximal humerus fracture
massive amounts data collected numerous sources like social media commerce websites challenging aspect analysis using available storage technologies relational databases traditional approach data storage suitable structured data formats constrained atomicity consistency isolation durability acid properties modern world data form word documents pdf files audio video formats unstructured therefore tables schema definition major concern relational databases mysql may suitable serve bigdata alternate approach use emerging nosql databases work comprehensive performance scalability evaluation large web collection data data stores nosql cassandra relational mysql presented systems evaluated data workloads found related bigdata yielding scalability applications insights presented work serve performance scalability also lessons learned experiences relating configuration complexity evaluation sorting complex queries data storage used usage cases large data sets results show bigdata collected across web billions records generating continuously poorly evaluated mysql terms write operations perform well nosql cassandra paper yields new approach unique representing nosql cassandra poor performance retrieval records disk utilisation ever increasing loads results presented paper show improvement read performance proposed architecture configuration mysql achieving cost saving benefits organisation willing use nosql cassandra managing bigdata heavy loads
magnetic resonance measurements brainstem structures reported useful differentiating patients progressive supranuclear palsy psp parkinson disease aim study determine whether quantitative measurements brainstem structures images help differentiate vascular parkinsonism vap degenerative parkinsonism psp areas midbrain pons widths superior cerebellar peduncle scp middle cerebellar peduncle mcp measured patients patients psp probable possible patients vap weighted images midbrain pons area ratio ratio mcp scp width ratio mcp scp ratio parkinsonism index mrpi mcp scp calculated midbrain area ratio patients vap respectively smaller patients respectively larger patients psp respectively mrpi significantly larger patients psp comparison vap however mrpi patients vap significantly different patients study showed mrpi useful differentiating psp vap thus imaging measurements brainstem structures may help differentiate patients vap psp
fungal infection extremely rare etiology exit site tunnel infection patients continuous ambulatory peritoneal dialysis capd data available regarding management especially choice antifungals duration therapy removal catheter guidelines pertaining reinsertion capd catheter following fungal exit site tunnel infection case report highlights candida albicans rare cause exit site tunnel infection capd catheter catheter removed patient received appropriate antifungal therapy followed reinsertion capd catheter initiation capd
renewable portfolio standards rpss popular market based mechanisms promoting development renewable power generation however usually implemented without considering capabilities cost transmission infrastructure use single multi stage planning approaches find cost effective transmission generation investments meet single multi year rps goals respectively using six node network assuming linearized power flow examine lumpy nature network reinforcements kirchhoff voltage law affect performance rpss first show simplified planning approaches ignore transmission constraints transmission lumpiness kirchhoff voltage law yield distorted estimates type location infrastructure well inaccurate compliance costs meet renewable goals second illustrate lumpy transmission investments kirchhoff voltage law result compliance costs nonconvex respect rps targets sense marginal costs meeting rps may decrease rather increase target raised thus value renewable energy certificates recs also depends network topology amount noncompliance rps noncompliance penalized prohibited finally use multi stage planning model determine optimal generation transmission infrastructure rps designs set multiyear goals find optimal infrastructure meet rps policies enforced year year differ optimal infrastructure banking borrowing allowed rec market
present time virtual simulation become popular subject computer graphics main goal simulation context computer graphics reproducing natural phenomena surrounding true life possible way representing natural phenomena sensible factor increasing reality among many kinds simulations realistic ocean simulation become important arena actually interesting natural object model two third surface earth covered ocean water intrinsic part day day life different models represent ocean surface however due highly dynamic behavior ocean representing visual complexity phenomena using basic simulation models challenge thus ocean water simulation computationally expensive process main aim research proposing substantive ocean wave visualization model taking account different sea states proposed beaufort sea scale since yet single approach satisfactory outcome state sea changing time time according wind speed various phenomena dynamic feature important serious computer games simulators use maritime trainings rendering mechanism suggests thesis intended provide efficient accurate method represent high quality visual characteristics runs real time produce highly realistic ocean scenes regardless complexity wave model building mathematical model representing shape ocean surface objective research suitable existing wave models used study thesis trying identify suitable wave model among different kind existing wave models representing selected sea state
paper aims contribute existing studies young women transition adulthood case turkish women exclusion labour market issue discussed largely within boundaries traditional gender restrictions keep women employment herein argue gender based control young women perceived reason exclusion labour market may used disadvantaged women way avoiding difficult unfavourable employment situations similarly gender roles imposed men could also fulfilled due restrictive labour market conditions furthermore suggest poverty simultaneously strengthens erodes base traditional gender structure young women young men forcing young women employment young men unstable working conditions argument based study conducted altnda ankara sample females males aged mixed methodology comprising survey questionnaire followed depth interviews focus group discussions employed study
emergency contraception used unprotected sex inadequately protected sex sexual assault reduce risk pregnancy emergency contraceptive methods available united states copper intrauterine device highest efficacy followed ulipristal acetate levonorgestrel containing emergency contraceptive pills yuzpe method however access effective methods limited although advanced prescription emergency contraceptive pills counseling emergency contraception reproductive aged women recommended women advised contact health care providers taking emergency contraceptive pills discuss possible copper intrauterine device placement follow
objective spike sorting fundamental preprocessing step many neuroscience studies rely analysis spike trains feature extraction dimensionality reduction techniques used spike sorting give projection subspace necessarily discriminative one therefore clusters appear inherently separable discriminative subspace may overlap projected using conventional feature extraction approaches leading poor sorting accuracy especially noise level high paper propose noise robust unsupervised spike sorting algorithm based learning discriminative spike features clustering approach proposed algorithm uses discriminative subspace learning extract low dimensional discriminative features spike waveforms perform clustering automatic detection number clusters core part algorithm involves iterative subspace selection using linear discriminant analysis clustering using gaussian mixture model outlier detection statistical test discriminative subspace proposed automatically detect number clusters main results comparative results publicly available simulated real vivo datasets demonstrate algorithm achieves substantially improved cluster distinction leading higher sorting accuracy reliable detection clusters highly overlapping detectable using conventional feature extraction techniques principal component analysis wavelets significance providing accurate information activity number individual neurons high robustness neural noise outliers proposed unsupervised spike sorting algorithm facilitates detailed accurate analysis single multi unit activities neuroscience brain machine interface studies
objective study compare performance partial least square regression plsr best narrowband normalize nitrogen vegetation index nnvi linear regression models predicting concentration best narrowband normalize different vegetation index ndvi end season biomass yield bioenergy crop production systems canopy hyperspectral data collected using asd fieldspec spectroradiometer monthly intervals cropping systems evaluated study perennial grass mixed grass switchgrass panicum virgatum indian grass cheyenne sorghastrum nutans nash big bluestem kaw andropogon gerardii vitman switchgrass alamo high biomass sorghum blade sorghum bicolor moench grown variable applications rates estimate biomass yield quality nnvi computed wavebands pair high biomass sorghum perennial grass strongly correlated concentration years wavebands used computing best narrowband ndvi highly variable wavebands red edge region provided best correlation narrowband ndvi weakly correlated final biomass yield perennial grass rmse rmse strongly correlated high biomass sorghum rmse compared best narrowband rmse plsr model lower estimating concentration lower final biomass results indicates plsr might best predicting final biomass yield using spectral sample obtained june july narrowband nnvi robust useful predicting concentration
gpu widely used various applications require huge computational power paper contribute cryptography high performance computing research community presenting techniques accelerate symmetric block ciphers aes cast camellia seed idea blowfish threefish nvidia gtx maxwell architecture proposed techniques consider various aspects block cipher implementation gpu including placement encryption keys box memory thread block size cipher operating mode parallel granularity data copy cpu gpu proposed new method store encryption keys registers high access speed exchange threads using warp shuffle operation gpu block ciphers implemented paper operate ctr mode able achieve high encryption speed gbps aes gbps cast gbps camelia gbps seed gbps idea gbps blowfish gbps threefish best knowledge first implementation block ciphers exploits warp shuffle advanced feature nvidia gpu hand block ciphers used pseudorandom number generator prng operating counter mode ctr speed usually slower compare prng using lighter operations hence attempt modify idea blowfish order achieve faster prng generation modified idea blowfish manage pass nist statistical test testu smallcrush except stringent tests testu crush bigcrush
introduction free text fields injury surveillance databases provide detailed information beyond routinely coded data additional data exposures covariates identified narrative text used conduct case control studies methods illustrate developed text search algorithm identify helmet status worn worn use unknown national electronic injury surveillance system neiss narratives bicycling sports injuries calculated adjusted odds ratios ors head injury associated helmet use non head injuries representing controls bicycling validated ors published estimates ors calculated sports examined factors associated helmet reporting results bicycling injury narratives reviewed contained sufficient helmet information use case control study adjusted ors head injuries associated helmet wearing smaller directionally consistent previously published estimates cochrane review ors illustrated protective effect helmets sports well less conclusions exploratory analysis illustrates potential utility relatively simple text search algorithms identify additional variables surveillance data limitations study include possible selection bias inability identify individuals multiple injuries similar approach applied study injuries conditions risks protective factors approach may serve efficient method extend utility injury surveillance data conduct epidemiological research elsevier ltd rights reserved
background contraception little researched topic saudi arabian context receives attention demographic transition implications population policy population saudi arabia appears homogeneous shows differences across social economic groups important component demography contraception hypothesized saudi arabia determinant fertility along factors age first marriage women educational attainment husband education child deaths women work force participation place residence type family preference sons level living administrative area residence hypothesis significance due fertility differentials depending upon marital relations female literacy modernization migration study intends capture attention academicians social reformers line building happy families specific objectives study assess associates determinants contraceptive use ascertain importance factors promoting contraceptive use methods contraceptive use unique group ever married women employees king saud university riyadh examined aim assessing associates determinants sample women drawn simple random sampling method tested self administered questionnaire analyses primarily means age first marriage age husband marriage age gap spouses years lived husband number children association demographic geographic social economic variables determinants results demographic variables age number marriages age husband first marriage continuing first marriage geographic variable place grown social variables type family type job economic variable income significant associates contraceptive use meanwhile age continuing first marriage age first marriage number children home ownership significant predictors conclusions recommendations manipulation indicators characteristics women facilitate demographic scenario desired kingdom conceptualized population policy middle east fertility society production hosting elsevier
thick hydrophilic microporous poly vinylidene fluoride pvdf affinity membranes prepared low concentration gold separation grafting thiourea alkali treated pvdf resin modified polymer easily cast membranes non solvent induced phase separation two coagulation processes addition methyl pyrrolidone second coagulation bath improved pore size distribution effectively grafted polymer membrane characterized ftir raman nmr xps sem pore size distribution measurement static adsorption iii membranes followed pseudo second order kinetics langmuir isotherm dynamic adsorption investigated using stacked membranes form membrane chromatography results showed increasing number membrane layers improved membrane bed utilization attributed increased adsorption sites combined effect reduced average membrane pore size narrowed pore size distribution psd effect psd performance membrane chromatography separated mean pore size shown narrower psd indeed favorable new mathematical model based dispersive mass transfer membrane pores incorporating psd established model found able predict membrane breakthrough behavior well finally elution performance gold laden membrane studied optimized formulation eluent consisting thiourea hcl determined elsevier rights reserved
state space formulation aerodynamics flapping flight presented duhamel principle applied linear unsteady flows extended non conventional lift curves capture lev contribution aspect ratio effects empirical formulae used predict static lift due stabilized leading edge vortex lev provided unsteady lift due arbitrary wing motion generated using static lift curve state space representation unsteady lift derived proposed model validated comparison direct numerical simulations navier stokes hovering insects comparison quasi steady models capture lev contribution also performed assess role unsteadiness similarly comparison classical unsteady approaches presented assess lev dominance finally reduced order model suitable flight dynamics control analyses derived full model elsevier masson sas rights reserved
typical internet things iot applications involve collecting information automatically diverse geographically distributed smart sensors concentrating information powerful computers raspberry platform become interesting choice iot applications several reasons good computing power cost ratio high availability become facto hardware standard ease use based operating systems big community users iot applications data frequently carried means wireless sensor networks energy consumption key issue energy consumption especially relevant smart sensors scattered wide geographical areas may need work unattended batteries long intervals time scenario convenient ease construction iot applications keeping energy consumption minimum sensors work proposes possible gateway implementation specific technologies solves following research question build gateways iot applications raspberry low power iqrf communication modules following contributions presented one architecture iot gateways integrates data sensor nodes higher level application based low cost low energy technologies bindings java ease construction iot applications empirical model describes consumption communications nodes smart sensors allows scaling batteries validation proposed energy model battery operated nodes
background previous studies reported varying return sport protocols knee cartilage restoration procedures purpose evaluate time return sport athletes isolated chondral injury underwent accelerated return sport protocol osteochondral autograft plug transfer oat evaluate clinical outcomes assess consequences accelerated return sport study design case series level evidence methods institutional cohort oat procedures reviewed competitive athletes met inclusion exclusion criteria patients underwent physician directed accelerated rehabilitation program procedure return sport determined athletes clinical outcomes assessed using international knee documentation committee ikdc tegner scores well assessment level participation return sport results return sport data available athletes athletes available clinical evaluation mean year follow mean time return sport athletes days range days athletes able return sport previous level reported satisfied satisfied surgical outcome ability return sport mean postoperative ikdc score mean tegner score prior injury final follow conclusion competitive athletes traumatic chondral defects treated oat managed using protocol reduced time preinjury activity levels compared currently reported excellent clinical outcomes serious long term sequelae
incidence progression kidney diseases influenced sex renin angiotensin system ras important regulator cardiovascular renal function sex differences renal response ras blockade demonstrated circulating renal ras shown altered type type diabetes enzymatic cascade plays critical role development diabetic nephropathy angiotensin converting enzyme ace ace differentially regulated depending localization within diabetic kidney furthermore clinical experimental studies shown circulating levels sex hormones clearly modulated context diabetes suggesting sex dependent ras regulation may also affected individuals effect sex hormones circulating renal ras may involved sex differences observed progression paper review influence sex hormones ras expression relation diabetic kidney disease better understanding sex dimorphism ras might provide new approach diabetic kidney disease treatment
biofilms ubiquitous pipes drinking water distribution systems dwdss recent experimental studies revealed chlorination microbial carbon associated biofilm contributes total disinfection products dbps formation distinct mechanisms formed precursors derived natural organic matter nom multiple species reactive transport model developed explain role biofilms dbps formation accounting simultaneous transport interactions disinfectants organic compounds biomass using parameter values experimental studies literature model equations solved predict chlorine decay microbial regrowth dynamics actual dwds trihalomethanes thms formation pilot scale distribution system simulator model capability reproducing measured concentrations free chlorine suspended biomass thms different hydrodynamic temperature conditions demonstrated contribution bacteria derived precursors total thms production found significant dependence system hydraulics seasonal variables quality treated drinking water system conditions promoted fast bacterial growth transformation non microbial microbial carbon dbp precursors biofilms showed noticeable effect kinetics thms formation especially high initial chlorine dose applied conditions included elevated water temperature high concentrations nutrients influent water fraction thms formed microbial sources found reach peak total produced thms investigated scenarios results demonstrated importance integrating bacterial regrowth dynamics predictive dbps formation models elsevier ltd rights reserved
prevalence obesity disability older adults significant public health implications case review discusses benefits risks weight loss older adults outlines treatment options available medicare beneficiaries importance preserving lean muscle mass weight management emphasized
non linear semi active vibration control devices experienced significant development recent years due performance advantages compared passive active approaches pulse switching techniques developed field piezoelectric damping lead effective trade offs performance simplicity required power supply control law method based triggering inverting switch extremum produced voltage displacement however case random excitation false switching local maxima reduce efficiency overwhelmingly successful approach overcome limitation based windowed statistical examination vibration signal determine optimum triggering voltage level according approach paper presents modified method first time presents novel circuit structure predict optimum trigger time damping switch circuit structure implementable using compact analog devices embedded vibration energy extraction system proposed circuit calculates statistical parameters displacement sensor signal estimates value threshold results cantilever beam excited different excitation forces harmonic random samples pulse forces presented compared numerical simulations elsevier rights reserved
objective quantify prevalence irritable bowel syndrome ibs among medical students king saud bin abdulaziz university health sciences ksau observe association anxiety ibs methods cross sectional observational study conducted academic year used two self administered pre validated questionnaires depression anxiety stress scales dass rome iii criteria sample size proportional allocation used determine distribution sample across study population based percentages students academic year convenience sampling used select participants results overall prevalence ibs higher prevalence among females males ibs least prevalent among first year students fifth year students respectively anxiety levels normal mild moderate severe extremely severe significant association found gender ibs anxiety levels ibs conclusion prevalence ibs study higher among females males highest among fifth year students genders students moderate high levels anxiety genders prevalence ibs highest among students fifth year study provides evidence medical students higher year graduation higher level anxiety leads ibs
objective objectives study assess serum levels testosterone differ men without elevation myocardial infarction determine association testosterone outcome elevation myocardial infarction stemi methodology hospital based case control study conducted coronary care unit teaching hospital karapitiya galle sri lanka january december two hundred six males patients stemi controls without history cad studied followed one year occurrence clinically significant adverse cardiovascular events serum total testosterone lipids plasma glucose estimated results basal serum total testosterone patients significantly lower compared controls nmol results showed total testosterone significant independent predictor stemi significant independent predictors hospital complications conclusion men stemi significantly lower basal serum total testosterone compared controls low testosterone risk factor stemi testosterone independently related development hospital complications stemi
previous studies waste incineration part energy system show waste management energy supply highly dependent preconditions energy system setup affects avoided emissions thereby even sometimes total outcome environmental assessment however previously shown explicitly key parameters crucial much parameter affects results conclusions different aspects depend interconnection waste incineration energy system elaborated testing parameters potentially crucial result design incineration plant avoided energy generation degree efficiency electricity efficiency combined heat power plants chp avoided fuel emission level avoided electricity generation avoided waste management emissions calculated incineration kwh mixed combustible waste results indicate one important factors electricity efficiency chp plants combination emission level avoided electricity generation novel aspect study plant plant comparison showing different electricity efficiencies associated different types fuels plants influence results since waste incineration typically lower power fuel ratios implications analyses waste incineration compared waste management practises heat power production technologies new incineration capacity substitute mixed landfill disposal recovered energy replace energy inefficient high polluting plants electricity generation must lost compensated electricity production affecting overall results
paper discuss important integrity constraint called multivalued dependency mvd occurs result first normal form framework newly proposed model called fuzzy mutivalued relational data model fuzzy multivalued relational data model proposed paper accommodates wider class ambiguities representing domain attributes set fuzzy subsets show model able represent multiple types impreciseness occurring real world compute equality two fuzzy sets values occur tuple values use concept fuzzy functions main objective paper extend mvds context fuzzy multivalued relational model wider class impreciseness captured since mvds may exist isolation complete axiomatization set fuzzy functional dependencies ffds mvds fuzzy multivalued relational schema provided role fmvds obtaining lossless join decomposition discussed also provide set sound inference rules fmvds derive conditions inference rules complete also derive conditions obtaining lossless join decomposition fuzzy multivalued relational schema presence fmvds finally extend abu algorithm find lossless join decomposition context fuzzy multivalued relational databases apply concepts fmvds developed real world application technical institute demonstrate concepts fit well capture multiple types impreciseness
computer aided process planning important component linking design manufacturing computer aided design computer aided process planning computer aided manufacturing integrated manufacturing systems operation sequencing computer aided process planning one essential tasks solve problem acquire optimal process plans operation sequencing modeled combinatorial optimization problem various constraints novel modified ant colony optimization algorithm developed solve ensure feasibility process plans constrained relationships considered among operations classified two categories called precedence constraint relationships clustering constraint relationships operation precedence graph based constrained relationships formed get visual representation ensure good manufacturing economy mathematical model optimization total weighted production cost weighted resource transformation time related machine changes setup changes tool changes machines tools utilized evaluation criterion avoid local optimum enhance global search ability adaptive updating method local search mechanism embedded optimization algorithm case studies three parts carried demonstrate feasibility robustness modified ant colony optimization algorithm comparisons modified ant colony optimization algorithm previous genetic algorithm simulated annealing algorithm tabu search particle swarm optimization algorithm discussed results show modified ant colony optimization algorithm performs well operation sequencing problem
sports related injuries common children adolescents reported incidence around one ten children year boys incur severer sports injuries girls chance injury greater contact jumping sports sports injuries seen children years age non specific including contusions mild sprains extremity fractures usually salter fractures physes growth plate plastic fractures young athlete sports injury ligaments muscle rare spine head injuries growth adolescence intensity sports involvement increases pre pubertal children still open physes prone injury acute due stress repetitive activity addition injury physes long bones injuries physes apophyses common ligamentous injury uncommon physeal closure occur physes fuse ligamentous injury seen patterns similar adults review include description sports related injuries seen children adolescents concentrate injuries specific growing skeleton brief mention seen fusion physes
background adverse effects stress wellness trauma team members well established however level stress never quantitatively assessed aim study assess level stress using subjective data objective heart rate variability hrv among attending surgeons ass junior residents jrs pgy pgy senior residents srs pgy pgy trauma activation emergency surgery methods preformed prospective study enrolling participants eight hour calls level trauma center stress assessed based decrease hrv recorded using body worn sensors stress defined hrv less baseline hrv collected subjective data stress participant calls three groups ass jrs srs compared duration different stress levels trauma activation emergency surgery results total participants ass jrs srs evaluated hours included trauma activations emergency surgeries stress level increased trauma activations operations regardless level training ass significantly lower stress compared srs jrs trauma activation emergency surgery level stress similar jrs srs trauma activation emergency surgery correlation objectively measured stress level subjectively measured stress using state trait anxiety inventory among surgeons residents conclusions surgeon wellness significant concern study provides empirical evidence trauma acute care surgeons encounter mental strain fail recognize stress management burnout important high intensity field research may provide insight finding practitioners risk level evidence epidemiologic study level
paper proposes technique build spice micromodels integrated circuits bipolar technology appropriate simulate single event transients first show obtain spice models internal transistors texts scientific academic literature next several strategies figure internal structure integrated circuits bias point shown finally simulation results compared data issue experiments either performed authors researchers simulations require expensive software hardware paper start point research groups small budget academic purposes universities
efficient computational models retain essential physics associated continuous mathematical models important several applications including acoustic horn optimization heterogeneous wave propagation models naturally posed unbounded domains crucial physical requirement scattered fields radiating satisfy radiation condition infinity describe implement efficient high order coupled computer model acoustic wave propagation unbounded region comprising bounded heterogeneous media several obstacles unbounded heterogeneous media computer model retains radiation condition exactly hence readily applicable celebrated acoustic horn problem approach suitable using standard low order approximation radiation condition using parallel computing environments demonstrate high order algorithm extensive numerical experiments computational analysis including model horn problem several material property parameters efficient computer models validation work lead interesting mathematical numerical analysis problems acoustic system defined unbounded heterogeneous media comprising smooth non smooth horn impenetrable penetrable obstacles elsevier rights reserved
gene environment interactions moderate aggressive behavior identified independently serotonin transporter htt gene monoamine oxidase gene maoa aim present study investigate epistasis interactions maoa variable number tandem repeat vntr httlinked polymorphism lpr child abuse effects aggressive tendencies group otherwise healthy adolescents group chinese male adolescents completed child trauma questionnaire youth self report child behavior checklist buccal cells collected dna analysis effects childhood abuse maoa vntr httlpr genotypes interactive gene gene environmental effects aggressive behavior analyzed using linear regression model effect child maltreatment significant three way interaction among maoa vntr httlpr sexual abuse relating aggressive behaviors identified chinese male adolescents high expression maoa vntr allele httlpr genotype exhibited highest aggression tendencies increase childhood findings reported support aggression complex behavior involving synergistic effects gene gene environment interactions
nano fibrillated cellulose nfc abundant renewable bio macromolecule received much attention research community study detailed herein related preparation photocatalytic nanocomposites consisting nano fibrillated cellulose magnetite titanium dioxide nanoparticles nfc feo tnp aim study improve photocatalytic efficiency nfc tnp composites improve recyclability photocatalytic hydrogen generation nfc feo tnp nanocomposites characterized tem edx saed xrd xps ftir raman spectra vsm techniques results showed feo tnp well distributed surface nfc photocatalytic efficiency study showed nfc feo tnp nanocomposites represented higher photocatalytic hydrogen generation rate comparison nfc tnp sample addition nfc feo tnp nanocomposites readily recovered system using magnet due stable superparamagnetic properties marginal loss tnp photocatalytic efficiency fifteen cycles published elsevier
quatman myer khoury wall hewett sex differences weightlifting injuries presenting united states emergency rooms strength cond res benefits resistance training include improved muscle strength sports performance may include reduced injuries however studies examined sex differences resistance training related injuries objective investigation evaluate sex differences injuries associated strength training adolescents young adults type sprains strains fractures mechanism accidental nonaccidental location head trunk arm hand leg foot injury hypothesized would sex differences type mechanism location strength training injuries consumer product safety commission cpsc national electronic injury surveillance system neiss queried using cpsc code weightlifting subjects ages years included study cpsc sampling weights used calculate national estimates sample patients men women weighted chi square analyses used compare differences mechanism type location injury men versus women men significantly sprains strains whereas women demonstrated increased accidental injuries compared men trunk commonly injured body part men women men trunk injuries women whereas women foot leg injuries men findings indicate men may suffer exertional type resistance injuries strength training sprains strains compared women especially trunk conversely women may susceptible lower extremity injuries resulting accidents resistance training
improving estimation accuracy energy consumption electric vehicles evs would greatly contribute alleviating range anxiety drivers serve critical basis planning operation management charging infrastructures address challenges energy consumption estimation encountered due sparse global positioning system gps observations estimation model proposed considers kinetic characteristics sparse gps observations unique attributes evs work opposing rolling resistance aerodynamic friction losses energy consumption generation depending grade route auxiliary load consumption additional energy losses arising unstable power output electric motor two quantities average energy consumption per kilometer energy consumption entire trip focused compared model fitness parameter effectiveness latter showed higher fitness based sparse gps observations evs aichi prefecture japan traditional linear regression approach multilevel mixed effects linear regression approach used model calibration proposed model showed high accuracy demonstrated great potential application using sparse gps observations predict energy consumption evs
increasing interest developing powerful flexible statistical tests detect genetic associations multiple traits arising neuroimaging genetic studies existing methods treat single trait multiple traits response treating snp predictor coded additive inheritance mode paper follow earlier approach treating snp ordinal response treating traits predictors proportional odds model pom way easier handle mixed types traits quantitative binary also potentially robust commonly adopted additive inheritance mode importantly develop adaptive test pom maintain high power across many possible situations compared existing methods treating multiple traits responses generalized estimating equation gee approach proposed method applied high dimensional setting number phenotypes larger sample size addition usual small setting promising performance proposed method demonstrated applications alzheimer disease neuroimaging initiative adni data either structural mri driven phenotypes resting state functional mri fmri derived brain functional connectivity measures used phenotypes applications led identification several top snps biological interest furthermore simulation studies showed competitive performance new method especially
introduction aim study clarify microrna mirna expression profiles raw macrophages infected candida albicans elucidate roles differentially expressed mirnas explore mechanisms underlying immune response albicans infection methods high throughput mirna microarray analysis performed detect differentially expressed mirnas control albicans infected raw cells quantitative real time pcr analysis used verify microarray results target genes differentially expressed mirnas predicted bioinformatics software cell biological processes signaling pathways mirna targeted genes involved albicans infection predicted gene ontology enrichment pathway analyses results significant upregulation eight mirnas mmu mir mmu mir mmu mir mmu mir mmu mir mmu mir mmu mir mmu mir downregulation eight mirnas mmu mir mmu mir mmu mir mmu mir mmu mir mmu mir mmu mir mmu mir observed compared control fold change analysis revealed mmu mir mmu mir participated immune responses inflammatory reactions cell apoptosis albicans infection also mapk signaling pathway found play important role immune response albicans infection conclusions study revealed comprehensive expression functional profiles differentially expressed mirnas macrophage raw cells infected albicans findings help elucidate mechanisms underlying immune response albicans infection
aim determine specific groups occupational stress factors influence duration temporary work disability related arterial hypertension joint complications morbidities methodology workers exposed group control group arterial hypertension worked one workplace minimum years divided subgroups depending presence joint complications morbidities intensity seven groups occupational stress factors total score occupational stress index osi average number lost working days year analysed results number lost working days due arterial hypertension joint complications morbidities significantly higher exposed group subgroups exposed group high correlation number lost working days total osi score specific occupational stress factors associated specific complications high demands chronic myocardial infarction strictness cerebral haemorrhage conflict uncertainty cerebral infarction extrinsic time pressure acute myocardial infarction avoidance symbolic aversiveness non insulin dependent diabetes conclusion specific groups occupational stress factors influence duration work disability associated certain complications morbidities arterial hypertension
cloud computing robust technology facilitate resolve many parallel distributed computing issues modern big data environment hadoop ecosystem process large data sets distributed computing environment hdfs filesystem hadoop process data blocks cluster nodes data block placement become bottleneck overall performance hadoop cluster current placement policy assumes datanodes equal computing capacity process data blocks computing capacity includes availability storage media processing performances node result hadoop cluster performance gets effected unbalanced workloads inefficient storage tier network traffic congestion hdfs integrity issues paper proposes storage tier aware robust data placement rdp scheme systematically resolves unbalanced workloads reduces network congestion optimal state utilizes storage tier useful manner minimizes hdfs integrity issues experimental results show proposed approach reduced unbalanced workload issue moreover presented approach resolve storage tier compatibility problem predicting storage block jobs improved overall data block placement pre calculated computing capacity allocations execution map files respective namenode datanodes
nowadays intelligent tutoring systems considered effective research tool learning systems problem solving skill improvement nonetheless individualized systems may cause students lose learning motivation interaction timely guidance lacking order address problem solution based intelligent tutoring system sits integrated online game based formative assessment game called tic tac toe quiz single player tris learning computer programming assessment game combines tic tac toe online assessment rules tic tac toe revised stimulate students use online formative assessment actively finally experimental study devised assess success sits significant achievements observed experimental group besides enjoyment positive opinions toward tris therefore practical use sits supported results indicate considerable advantages experimental group control group findings also reveal immediate elaborated feedback upon answering question tris part optimal design
objective determine injury rate athletes participating high school rodeo design retrospective report review setting national high school rodeo finals participants high school athletes qualified rodeo competitions state national qualifying rounds assessment risk factors injury reports documented sports medicine personnel variables evaluated injury density frequency mechanism injury injury location injury type follow request results total injury incidents front competitor exposures ces resulted composite injury density per rough stock athletes accounted injuries bareback riders followed bull riders saddle bronc riders demonstrated injury densities per respectively injuries sustained dismounting bucked animal contusions sprains strains frequent injury types respectively head shoulder respectively commonly injured body parts ail incidence density per found injury requiring transport ambulance conclusions high school rodeo athletes sustain similar injuries collegiate professional rodeo athletes indicating addressing issues youth level may great benefit better provide prevention tools rodeo athletes mechanism injury methods reduce buck need inquiry
magnetic resonance elastography mre requires substantial data processing based phase image reconstruction wave enhancement inverse problem solving objective study propose new fast mre method based raw data processing particularly adapted applications requiring fast mre measurement high elastogram update rate proposed method allows measuring tissue elasticity directly raw data without prior phase image reconstruction without phase unwrapping experimental feasibility assessed gelatin phantom liver porcine model vivo elastograms reconstructed raw mre method compared obtained using conventional mre third experiment changes elasticity monitored real time gelatin phantom solidification using conventional mre raw mre raw mre method shows promising results providing similar elasticity values ones obtained conventional mre methods decreasing number processing steps circumventing delicate step phase unwrapping limitations proposed method influence magnitude elastogram requirement minimum number phase offsets study demonstrates feasibility directly reconstructing elastograms raw data
purpose cross sectional study identify prevalence incontinence incontinence associated dermatitis iad australian acute care patients describe products worn manage incontinence provided bedside perineal skin care data inpatients collected days major australian teaching hospital mean age sample group years patients male prevalence rate incontinence urinary incontinence significantly prevalent females males chi iad occurred sample group incontinent patients iad semi formed liquid stool associated iad chi clinical indication fungal infection present patients iad absorbent disposable briefs common incontinence aids used soap water disposable washcloths clean products commonly available bedside data needed validate high prevalence studies address prevention iad effectiveness management strategies also needed
nowadays many organizations experience security incidents due unauthorized access information reduce risk incidents security policies often employed regulate access information policies however often restrictive users rights necessary perform assigned duties consequence access control mechanisms perceived users barrier thus bypassed making system insecure paper draw bridge social concept conviviality access control conviviality introduced social science concept ambient intelligence multi agent systems highlight soft qualitative requirements like user friendliness systems bridge gap conviviality security propose methodological framework updating adapting access control policies based conviviality recommendations methodology integrates extends existing techniques assist system designers derivation access control policies socio technical requirements system taking account conviviality system illustrate framework using ambient assisted living use case hotcity luxembourg
circadian rhythm disorders represent important component underlying pathology depression one subtypes depression disorders may play crucial role seasonal affective disorder sad bright light therapy blt reported novel promising treatment method sad since data revealing efficacy referred adult patients without comorbid disorders however recent years reports presented confirm usefulness blt specific subpopulations patients including children adolescents pregnant women present review summarizes applications blt antepartum depression childhood adolescence depression well patients suffering eating disorders although body evidence still small recommend use blt first line treatment depression eating disorders patient subpopulations appears blt may useful alternative adjunctive therapy diseases however specific clinical applications blt areas need investigation
organizational citizenship behaviors employee choosing perform beyond work expectations beneficial success organization little research form prosocial behavior private correctional agencies study first examine relationship two forms organizational commitment affective continuance organizational citizenship behaviors correctional staff maximum security private prison results ordinary least squares regression analysis supported predictions affective commitment would positive association organizational citizenship behaviors continuance commitment would negative association possible interventions private correctional organizations undertake encourage affective organizational commitment staff discussed
background incidence intentional carbon monoxide poisoning believed declined due strict federal emissions standards motor vehicles uniform application catalytic converters sought compare ambient levels produced automobiles without catalytic converters residential garage well sources commonly used intentional poisoning methods levels measured inside freestanding one car garage sources included automobile without automobile charcoal grill electrical generator lawn mower leaf blower results minutes operation level garage ppm car without catalytic converter ppm car equipped one levels operating burning sources charcoal ppm generator ppm lawn mower ppm leaf blower ppm conclusions emissions controls automobiles reduced intentional poisonings alternate sources may produce levels magnitude vehicles manufactured prior use catalytic converters involved care potentially suicidal individuals aware
atrial fibrillation affects million people worldwide prevalence expected double aging population atrial fibrillation confers fold higher risk ischemic stroke compared sinus rhythm present view role shared medical decision making combat global underutilization oral anticoagulation stroke prevention atrial fibrillation patients oral anticoagulation underuse widespread present within atrial fibrillation patients risk strata countries across income levels reasons oral anticoagulation underuse include probably limited poor risk stratification interpretation contraindications discordance physician prescription preferences actual administration comparing catastrophic event consequences atrial fibrillation related strokes may help physicians patients understand negative outcomes associated oral anticoagulation utilization magnitude oral anticoagulations neutralize atrial fibrillation burden
introduction foot ankle injuries fai common cases per day france unlike lateral ankle sprain las diagnosis midtarsal joint sprain mjs also known chopart joint sprain widely known prospective study aims detail epidemiology mjs compare las patients method study conducted within institution period months patients clinical signs predictive mjs without radiographic bone lesion underwent ultrasound assessment mjs diagnosed case least lesion dorsal midtarsal joint ligaments results total patients consulted fai clinical radiographic criteria ultrasound examination eighty two cases mjs diagnosed fais sports injuries frequent mjs mechanisms varied las inversion injury cases plantar hyperflexion sprain severe cases complete ligament tear clinical ultrasound analyses correlated cases mjs versus las conclusion mjs frequent difficult diagnose clinically often severe clinical presentation injury mechanisms differ ankle sprain ultrasound seems indispensable tool diagnosis elsevier masson sas rights reserved
objectives prejudice native americans overall group generally polarizes positive negative stereotypic extremes distinct subgroups may explain variability method using college student samples study preliminary study identified common native american subgroups main study women white mean age years participants rate subgroups basic dimensions stereotype content warmth competence elicited emotions admiration contempt elicited behaviors facilitation harm study preliminary study main study procedures replicated using nationwide samples main study women white mean age years results part similar native american subgroups emerged samples using stereotype content model scm fiske cuddy glick subgroups found vary along competence warmth space majority subgroups alcoholics lazy judged low competence warmth additional subgroups casino operators warriors ambivalently judged high competence low warmth subgroups perceived high competence warmth elicited admiration low competence warmth elicited contempt high competence elicited passive facilitation less passive harm high warmth elicited active facilitation less active harm conclusions native american stereotypes apparently characterized noble ignoble subgroups highlighting importance studying stereotypes subgroup level
recent computing devices execute massive parallel data requiring huge computing hardware satisfy increasing computing need gpus providing powerful computational capability employed execute graphics general purpose applications gpgpus thegpgpu executing multiple applications together increase data parallelism resulting high resource utilization improving resource utilization gpgpu increase gpgpu performance however various kinds applications different execution time depending workload sizes therefore one application completed earlier ones resource underutilization problem may happen hardware resource allocated early completed application becomes idle work cta aware dynamic streaming multiprocessors scheduling scheme proposed multiple applications execution gpgpu efficiently manage hardware resources simulation results show proposed cta aware dynamic scheduling scheme increase gpu performance average
dynamic computer vision control system incorporating open source software technologies python opencv used automate gravity based line liquid liquid extraction iodination enaminones continuous flow system able cope significant colouration organic reaction stream significant volume flow changes aqueous organic phase streams due extraction water soluble acetonitrile solvent elsevier ltd rights reserved
objective study reasons refusing iucd services spite need temporary contraception counsel client accepting long short term health benefits background india vast country sub continent majority population young reproductive age group comprises yet married group married want postpone pregnancy group wants space next pregnancy group tubectomy operation excellent permanent birth control measure valid groups specific need effective temporary reversible contraception different failure rates specific contraindications many temporary methods suit iucd one temporary contraception fulfils maximum criteria needed highly effective temporary used long term contraception spite advantages acceptance low various factors influence lack awareness fear unknown one area counselling one one method fruitful mass media usage wide publicity may arouse element interest needy women leading curiosity desire know counselling service provision may bring necessary change attitudes clients place duration study study conducted government maternity hospital sultan bazaar teaching hospital osmania medical college hyderabad january december total clients eligible iucd studied counselled iucd clients accepted got iucd inserted followed years results total patients agreed iucd insertions refused despite counselling illiterate women surprisingly study group professionals including doctors refused aged yrs less constituting potential group needing spacing method rural based women denote large unmet need spite city based women seek contraception services nil knowledge regarding contraception clients majority come low socioeconomic background needing urgent conduct awareness programmes resistance acceptance seen reason fear misconceptions conclusion lack awareness wrong notions main reasons refusing excellent non hormonal reversible effective contraception calls urgent attention counselling services wide governmental publicity
background little known trajectories ptsd symptoms across peripartum period women trauma histories specifically met lifetime ptsd diagnoses prior pregnancy present study seeks identify factors influence ptsd symptom load across pregnancy early postpartum study impact postpartum adaptation method current study secondary analysis pregnant women lifetime ptsd diagnosis derived larger community sample interviewed twice across pregnancy weeks weeks postpartum assessing socioeconomic risks mental health past ongoing trauma exposure adaptation postpartum results using trajectory analysis first examined natural course ptsd symptoms based patterns across peripartum found four distinct trajectory groups second explored factors demographic historical gestational shape ptsd symptom trajectories examined impact trajectory membership maternal postpartum adaptation found child abuse history demographic risk lifetime ptsd symptom count increased pregnancy onset ptsd risk whereas gestational ptsd symptom trajectory best predicted interim trauma labor anxiety women greatest ptsd symptom rise pregnancy likely suffer postpartum depression reported greatest bonding impairment infants weeks postpartum conclusions screening modifiable risks interpersonal trauma exposure labor anxiety ptsd symptom load pregnancy appears critical promote maternal wellbeing wiley periodicals
background proponents bioidentical estrogens claim superior treating menopausal symptoms including depressive symptoms small trials examining effects bioidentical estrogens depressive symptoms show conflicting results conducted systematic review assess effectiveness safety bioidentical estrogens treatment depressive symptoms peri postmenopausal women methods searched scientific literature randomized controlled trials least weeks duration comparing bioidentical estrogen placebo depressive symptoms menopausal women main outcome measure improvement depressive symptoms validated scale results found clinical trials met inclusion criteria two contained insufficient data quantitative analysis studies inclusive subjects complete data available inclusion meta analysis bioidentical estrogen clinically significant effect depressive symptoms standardized mean difference smd confidence interval pooled studies highly heterogeneous numerous approaches reducing heterogeneity unsuccessful subgroup analyses showed significant difference effect women treated adjunctive progestogen women treated unopposed estrogen perimenopausal postmenopausal mixed populations possible benefit perimenopausal women treated unopposed estradiol may diluted studies including older postmenopausal women whose depressive symptoms unrelated menopause conclusions first systematic review bioidentical hormone replacement therapy found bioidentical estrogen clear benefit treating depressive symptoms menopausal women heterogeneity available studies limits potential definitive conclusions future research compare bioidentical estrogen nonbioidentical estrogen treatment depressive symptoms perimenopausal women
objective studies relationships deprivation self reported health people aged years studies fully representative northern ireland older population article addresses gap method deprivation older people reported censuses relationship self reported health analyzed year span using multilevel modeling data northern ireland longitudinal study nils linked census returns deprivation measures include housing tenure property value access car educational employment area level income deprivation results older people suffering deprivation face significant health disadvantage year time span discussion health disadvantage stronger men women likely due conservative gender roles prevalent among northern ireland older population leading psychological distress especially among deprived men analysis found strongly significant area level effects aggravating health impact deprivation
present first multi viewpoint coronal mass ejection cme catalog events identified visually simultaneous total brightness observations twin secchi cor coronagraphs board solar terrestrial relations observatory mission multi view cme catalog differs past catalogs three key aspects events two viewpoints cross linked event assigned physics motivated morphological classification jet wave flux rope kinematic geometric information extracted semi automatically via supervised image segmentation algorithm database extends beginning cor synoptic program march end dual viewpoint observations september contains unique events events identified cors kinematic properties exist currently events cor events cor events examine several issues made possible cross linked cme database including role projection perceived morphology events missing cme rate existence cool material cmes solar cycle dependence cme rate speeds width existence flux rope within cmes discuss implications past singleviewpoint studies space weather research database publicly available web including available measurements hope become useful resource community
study conducted determine financial environmental effects water quality rainwater harvesting systems potential replacing tap water used washing machines rainwater studied analysis presented paper valid applications include washing machines tap water hardness may important wide range weather conditions rainfall year water hardness caco tap water prices euros different spanish urban areas individual buildings whole neighbourhoods scenarios including materials water storage capacity analysed rainfall essential rainwater harvesting tap water prices water hardness main factors consideration financial environmental analyses respectively local tap water hardness prices cause greater financial environmental impacts type material used water storage tank volume tank use rainwater substitute hard water washing machines favours financial analysis although tap water hardness significantly affects financial analysis greatest effect found environmental analysis hard tap water needed replaced found water price euro could render use rainwater financially feasible using large scale rainwater harvesting systems water hardness greater caco financial analysis revealed net present value greater euros dwelling could obtained neighbourhood scale could reduction global warming potential years ranging dwelling year elsevier rights reserved
relational databases linguistic data based hedge algebras introduced following approach data manipulation include linguistic data simpler efficient practical one basis paper present update operations relational databases linguistic data based update operations built mean semantically quantifying mapping sqm similarity relation depth length linguistic value belongs values domain attribute
study describes virtual programmable logic controller virtual plc web based system plc education consists educational simulations help students visualize abstract concepts practice programming device interfacing skills understand problem solving processes simple intelligent tutoring system results two preliminary evaluations also presented index terms plc intelligent tutoring system simulation manufacturing engineering education wiley periodicals inc comput appl eng educ published online wiley interscience www interscience wiley com doi cae
recently interesting variant chaotic image cipher using latin square studied extensively lack corresponding cryptanalysis hampers development paper performs cryptanalysis newly proposed chaotic image cipher using latin square based confusion diffusion despite claim cryptosystem high security demonstrate cipher broken chosen plaintext attack combined chosen ciphertext attack moreover improvement ideas original algorithm given enhance security
background purpose study investigate frequency serum anti saccharomyces cerevisiae antibodies asca anti neutrophil cytoplasmic antibodies anca anti nuclear antibodies anas iga reactive protein crp erythrocyte sedimentation rate esr fecal calprotectin association diagnosis endoscopic findings histopathologic clinical activity patients diagnosis suspected inflammatory bowel disease ibd methods observational cross section study designed including patients ibd suspected ibd asca anca anas iga crp esr measured patients divided according histological findings ulcerative colitis crohn disease others normal mucosa chronic proctocolitis nonspecific colitis ileitis descriptive analysis made associations evaluated using chi test kruskal wallis mann whitney test results association ibd asca levels statistically significant anca levels showed statistical significance ibd patients comparing levels within others statistical significance obtained large percentage patients high positive levels classified active histopathology significant percentage levels quiescent activity positive levels related serum activity markers statistical significance crp esr conclusions frequencies anca ascas established colombian population ibd patients histopathologic activity higher levels also found patients quiescent disease elevated levels
introduction anti diabetes medication regimen adherence clinical challenge elderly patients type diabetes comorbidities associated aging glucagon like peptide receptor agonists glp therapies exenatide weekly exenatide twice daily bid liraglutide daily increasingly used class drugs proven efficacy tolerability real world evidence adherence glp ras elderly disabled patients limited understanding drug class current study examined medication adherence medicare patients aged years initiating glp methods retrospective cohort study used medical pharmacy claims medicare members united states health plan diagnosed new initiators either exenatide exenatide bid liraglutide included patients ages continuously enrolled months pre post index medication adherence examined post index period using proportion days covered pdc results significantly higher percentage patients receiving exenatide pdc versus exenatide bid liraglutide initiating exenatide bid liraglutide conclusions results retrospective study suggest room improvement adherence glp ras medication adherence rates patients initiating therapy exenatide higher patients initiating therapy exenatide bid liraglutide research needed validate findings patient populations
objectives hong kong among highest mobile phone usage rates asia although mobile phone may foster adolescents communication parents peers also concern teens may become dependent mobile phone present study investigated psychometric properties mobile phone dependence questionnaire mpdq sample young adolescents method mpdq translated validated hong kong sample adolescents ages ages ages six schools representing various levels socioeconomic status subset students participated focus groups topic adolescents mobile phone usage result confirmatory factor analysis identified three psychological factors represented adolescents responses mpdq compulsive text messaging making receiving high number calls obsessive thinking using mobile phone using criterion score standard deviations mean students would classified showing mobile phone dependency higher rate among females males discussion positive examples mobile phone usage mobile parenting monitor children children use phone seek mobile tutoring teachers counselling tutoring suggested ways provide support adolescents using technology already integral part lives
assess changes health status men lower urinary tract symptoms associated benign prostatic hyperplasia luts bph using oab instruments evaluate sensitivity instruments data available large randomised phase iii trial men moderate severe storage voiding luts bph neptune men received fixed dose combination solifenacin plus oral controlled absorption system ocas formulation tamsulosin tocas tocas monotherapy placebo completed oab baseline weeks analysis covariance used estimate changes index vas oab changes dimension level summarised using paretian classification health change pchc improved health related quality life baseline seen treatment arms oab week although oab showed statistically significant differences active treatment placebo index score using pchc approach effect sizes active treatment groups large oab small showed high ceiling effect men reported full health baseline substantial proportion men reported improvements week several dimensions oab large ceiling effect substantially limited sensitivity population oab proved sensitive changes health status could considered complement source utilities health economic modelling
background migraine one severe primary headache disorders nature headache associated symptoms attack suggest underlying functional alterations brain study examined amplitude resting state fmri fluctuation migraineurs without aura mwa mwoa respectively healthy controls methods resting state functional mri images high resolution images acquired participants data analysis compared groups mwa control mwa mwoa mwoa control resting state networks identified melodic mean time courses networks identified participant networks time courses decomposed five frequency bands discrete wavelet decomposition amplitude frequency specific activity compared groups furthermore preprocessed resting state images decomposed wavelet analysis five specific frequency bands voxel wise voxel wise amplitudes compared groups non parametric permutation test results mwa control comparison discrete wavelet decomposition found alterations lateral visual network higher activity measured mwa group highest frequency band case mwa mwoa comparison networks showed higher activity frequency range mwa lateral visual network higher frequencies mwoa control comparison default mode network revealed decreased activity mwoa group band voxel wise frequency specific analysis amplitudes found higher amplitudes mwa compared mwoa fronto parietal regions anterior cingulate cortex cerebellum discussion amplitude resting state fmri activity fluctuation higher mwa mwoa results concordance former studies found cortical hyperexcitability mwa
purposealthough much written medicare part enrollment much less known beneficiaries personal experiences choosing part plan especially among rural residents study sought address gap examining geographic differences part enrollees perceptions plan decision making process including confidence choice knowledge program satisfaction available information methodswe used data medicare current beneficiary survey included adults ages older enrolled part time survey used ordered logistic regression model outcomes based beneficiaries perceptions part decision making enrollment process first accounting differences rurality adjusting sociodemographic health coverage characteristics findingsoverall half beneficiaries confident part knowledge rural beneficiaries lower odds confident plan chose satisfied amount information available decision making process adjusting covariates micropolitan residents continued lower odds confident plan chose conclusionspolicy makers pay particular attention making information part easily accessible beneficiaries addressing unique barriers rural residents accessing information making decisions reduced internet availability furthermore confidence decision making process may improved simplifying part program
paper investigates physical layer security multiuser peer peer mupp relay network amplify forward protocol secure user unclassified users coexist multi antenna eavesdropper eavesdropper wiretap confidential information two cooperative phases goal optimize transmit power source beamforming weights relays jointly secrecy rate maximization subject minimum signal interference noise ratio sinr constraint user individual total power constraints mathematically optimization problem non linear non convex facilitate efficient resource allocation algorithm design alternative null space beamforming scheme adopted relays simplifying joint optimization eliminating confidential information leakage second cooperative phase relay beamforming vector lies null space equivalent channel relay eavesdropper links although null space beamforming scheme simplifies design resource allocation algorithm considered problem still non convex obtaining global optimum difficult impossible employing sequential parametric convex approximation spca method propose iterative algorithm obtain efficient solution non convex problem besides proposed joint design algorithm requires feasible starting point also propose low complexity feasible initial points searching algorithm simulations demonstrate validity proposed strategy
classic theories emotion posit awareness one internal bodily states interoception key component emotional experience view indirectly supported data demonstrating similar patterns brain activity importantly anterior insula interoception emotion elicitation however study directly compared two phenomena within participants leaving unclear whether interoception emotional experience truly share functional neural architecture current study addressed gap knowledge examining neural convergence two phenomena within population one task participants monitored heartbeat another task watched emotional video clips rated emotional responses videos consistent prior research heartbeat monitoring engaged circumscribed area spanning insular cortex adjacent inferior frontal operculum critically interoception related cluster also engaged participants rated emotion activity correlated trial trial intensity participants emotional experience findings held across group level individual participant level approaches localizing interoceptive cortex together data clarify functional role anterior insula provide novel insights connection bodily awareness emotion elsevier inc rights reserved
ulvans ulva tested potential cosmetic properties human dermal fibroblasts crude ulvans ulvan kda extracted using patented acid solvent free process subjected depolymerization using ion exchange resin obtain low molecular weight ulvan ulvan dep kda biochemical characterization uhplc hrms analyses extracted ulvans showed high purity predominantly composed repeated ulvanobiouronic acid disaccharide fibroblast proliferation well hyaluronan collagen release assessed demonstrating ulvan reduced fibroblast proliferation rate ulvan dep significant effect ulvans ineffective induce collagen production induced significant increase hyaluronan production strong influence molecular weight thus crude depolymerized ulvans different metabolic activities dermal fibroblasts makes promising envisage development skin care field elsevier ltd rights reserved
background employment important part recovery individuals schizophrenia employment rate group low norway major system related barriers employment evident aims study reports competitive employment outcome year follow vocational rehabilitation study augmented cognitive remediation elements cognitive behaviour therapy cbt individuals schizophrenia spectrum disorders also investigates global functioning self esteem depression baseline predicts employment outcome change variables intervention period associated employment outcome method one hundred forty eight participants schizophrenia spectrum disorders six norwegian counties received months vocational rehabilitation augmented either cbt competitive sheltered workplaces used participants assessed baseline end intervention period year follow results year follow obtained competitive employment work placements competitive workplaces significant improvements found global functioning self esteem depression intervention period significant differences two intervention groups high baseline global functioning self esteem well positive change variables intervention period significantly associated higher competitive employment outcome year follow conclusion results add existing evidence competitive employment attainable individuals schizophrenia high global functioning self esteem strongly associated competitive employment outcome
sexual abuse perpetrated parent particularly mother creates turmoil child depend person betrays trust review literature confirms case studies mother child incest reported psychoanalytic literature incidence incest however unknown considerably information available forensic child abuse literatures along increase research yet paucity data child sexual abuse women highly prevalent described early societies bias peoples minds capacity females sexually abuse children raised many writers fact abused one mother brings specific issues survivors maternal incest shame fear believed experience female patient sense specialness failure recognition incest males created particular difficulties dealt psychotherapy paper describes three teenagers one female two males sexually abused mothers condensed several years treatment provide account female patient summary males attempt explore dynamics relatedness abused abuser
recent years several model driven proposals defined user interface models represent behavioural aesthetic aspects however software industry ignored majority proposals quality rich user interfaces generated models usually low code generators flexible templates customised easily furthermore proposals facilitate separation visual design normally performed graphic designers industry visualisation data previously modelled using another domain specific language paper proposes new textual domain specific language called xanui could embedded xml based pages html xml designed language provides mechanisms bind visual components data structures already existing define behaviour components based events paper xanui integrated two oohria development processes traditional data intensive new design first process thus reusing oohria models transformations generate complete rich internet application platform device order validate approach xanui solution applied development ria two types administration view web application using html angularjs catalogue application commerce using windows tablet
moisture measurement ppm level always challenging costly among different technologies available moisture measurement thin film capacitive sensor based dew point meter offers low cost solution still cost dew point meter high suffers high response time need wireless moisture measurement ppm level available commercial meter according knowledge paper deals development low cost passive wireless tag capacitive type sensors tag energized mhz commercial tag reader distance approx tag capable transmitting sensor data ghz ism band distance efficient algorithm developed reduce power consumption prototype system tested two custom designed capacitive sensors measure humidity wide range sensors highly stable hygroscopic film alo fabricated lab finally low cost approximately digital hygrometer measure trace moisture developed performances digital hygrometer compared commercial dew point meter accuracy found nearly range ppm moisture system employed contactless measurement capacitive sensor range
numerous long span bridges built throughout world recent years bridges progressively damaged continuous usage throughout long service life failure local structural components detrimental performance entire bridge furthermore detecting local abnormality early stage difficult paper explores novel damage detection method long span bridges incorporating stress influence lines sils control charts validates efficacy method case study tsing suspension bridge damage indices based sils subsequently proposed applied hypothetical damage scenarios one two critical bridge components subjected severe damage comparison study suggests first order difference sil change accurate indicator location damage extent different levels damage quantified using sils incorporating bar control chart results study indicate proposed sil based method offers promising technique damage detection long span bridges
objective evaluate effectiveness crisis response planning prevention suicide attempts method randomized clinical trial active duty army soldiers fort carson colorado presenting emergency behavioral health appointment participants randomly assigned receive contract safety standard crisis response plan enhanced crisis response plan incidence suicide attempts follow assessed suicide attempt self injury interview inclusion criteria presence suicidal ideation past week lifetime history suicide attempt exclusion criteria presence medical condition precluded informed consent active psychosis mania survival curve analyses used determine efficacy time first suicide attempt longitudinal mixed effects models used determine efficacy severity suicide ideation follow mental health care utilization results baseline month follow participants receiving crisis response plan estimated proportion participants receiving contract safety estimated proportion attempted suicide log rank chi hazard ratio suggesting reduction suicide attempts crisis response planning associated significantly faster decline suicide ideation fewer inpatient hospitalization days differences enhanced standard crisis response plan conditions conclusion crisis response planning effective contract safety preventing suicide attempts resolving suicide ideation reducing inpatient hospitalization among high risk active duty soldiers
social networking sites sns popular internet based technology enable users communicate interact sns attracted great deal scholarly attention used educational tool recent years however little research examining motivations obstacles teaching sns higher education therefore purpose study investigate faculty members higher education prefer use use sns educational purposes end faculty members current sns usage purposes using sns opinions faculty members uses sns education investigated mixed method approach utilized collect data total faculty members eight different state universities turkey findings show nearly half faculty members possessed sns account reported use sns educational purposes greatest motivating factor use sns sns provide means fast effective communication main factor impeded sns usage faculty members concerns privacy elsevier ltd rights reserved
research focused use active infrared thermography non destructive testing technique damage detection carbon fiber reinforced plastics cfrps aim study examine efficiency various mathematical methods thermographic data processing respect thermal excitation method type artificial defect cfrp specimens applied two techniques active infrared thermography cfrp samples artificial cracks internal laminations known locations infrared camera recorded temperature field generated sequence thermal images reveal defects cfrp laminate thermograms processed images pixel signal time present representative experimental results illustrate depiction norm spatial derivative temperature wavelet transforms proved efficient crack detection whereas fourier wavelet transforms yield clear results contrast delamination damages could identified techniques fourier transform well wavelet transform accurate elsevier masson sas rights reserved
paper propose technique low observability uses active signal tuning real time control object surface temperature according varying background environment achieved applying proper object surface temperature obtained result minimum radiance difference object background experimental verification using thermoelectric temperature control element shows radiance contrast object background reduced night day time compared tuned original radiance contrast values stealth technology demonstrated paper may applied many military systems needed stealth performance suitable temperature control unit developed
software developers use many different communication tools channels work diversity tools dramatically increased past decade developers access wide range socially enabled communication channels social media support activities availability social tools leading participatory culture software development developers want engage learn create software developers however interplay social channels well opportunities challenges may create used together within participatory development culture yet well understood paper report large scale survey conducted github users discuss channels developers find essential work gain understanding challenges face using findings lay empirical foundation providing recommendations developers tool designers use improve tools software developers
research investigated effect guide vanes intake runner diesel engine run higher viscous biodiesel enhance cylinder intake airflow characteristics first simulation internal combustion engine base model done guide vanes various lengths developed imposed intake runner investigate airflow characteristics based simulation results five guide vanes models length constructed tested compression ignition engine run biodiesel according experimental results engine performance emissions found guide vanes length showed highest number improvements length showed second third highest number improvements respectively therefore research concluded guide vanes successfully improved cylinder air flow characteristics improve mixing higher viscous biodiesel air resulting better performances engines without vanes
adhesive bonding unions structures gaining momentum welding riveting fastening vital design bonded structures availability reliable damage models predict fracture behaviour cohesive zone models czm extensively used past taking advantage traction separation laws stresses relative displacements simulate crack growth along predefined paths extended finite element method xfem recent improvement finite element method fem relies damage laws based bulk strength materials damage initiation strain assessment failure rather tipping tractions tensile shear relative displacements used czm compared fem xfem excels allowing discontinuities grow within bulk solids along arbitrary path work aims assess viability xfem predict fracture behaviour thin layer adhesive stiff compliant adherends build xfem damage laws fracture toughness pure mode tensile cohesive strength sigma two adhesives initially determined double cantilever beam dcb bulk tensile tests respectively particular emphasis given influent parameter numerical predictions numerical simulations dcb tests proposed laws matched accurately experimental load displacement delta curves validated analysis procedure accuracy data reduction methods calculation checked comparison input values simulations results calculations good results elsevier rights reserved
take challenge global distributed companies manufacturing engineering accomplished worldwide collaborative way design development production processes execution nowadays spread world ensure quality standards create synergies spatially distributed entities distance collaboration tools must provided allow cooperation even large distances virtual reality thereby offering beneficial capabilities exchange current planning stages identify problems solve cooperatively paper introduces new approach distance collaboration enables users work joint virtual space nearly working together place therefore two full immersive cave like systems interconnected using virca virtual collaboration arena platform paper describes requirements mechanical engineers towards distance collaboration tools technical challenges solved enhanced virca framework working prototype one premier application field enhanced spatially distributed collaboration typical use case scenario provided highlight interaction cooperation capabilities offered virca net
faces play integral role day day functioning particularly social interactions dynamic rapid processing information vital analysis faces allows individual ascertain wide range information including deciphering mood identity assessments directing individual subsequent response behaviours prominent social emotional deficits observed frontotemporal dementia ftd youngeronset dementia syndrome may part reflect breakdown face processing network different subtypes ftd present divergent patterns atrophy although damage predominantly confined frontal temporal lobes specific predictions regarding role frontal temporal regions face processing proposed model outlined haxby trends cognitive sciences model presents parsimonious method understand face processing ftd concurrently allowing assessment predictive value applicability model applying haxby model existing ftd literature review presents direct indirect evidence breakdown key elements face processing network type degree breakdown appears differ function ftd subtype associated brain atrophy evidence presented review relationship predictions haxby model provides impetus direction future research investigating face processing ftd
new solution ultra low voltage low power bulk driven operational amplifier presented paper amplifier based new input stage exploiting concept partial positive feedback compared prior work proposed input stage offers improvement basic performance metrics including important parameters input referred noise offset voltage order improve voltage gain overall amp novel solution ultra low voltage high input resistance common mode amplifier also proposed simulated performance overall operational amplifier cmos process supply voltage shows power dissipation open loop voltage gain gain bandwidth product mhz load capacitance
aimto describe new graduate nurses transition experiences canadian healthcare settings exploring perspectives new graduate nurses nurse leaders unit level roles backgroundsupporting successful transition practice key retaining new graduate nurses workforce meeting future demand healthcare services methoda descriptive qualitative study using inductive content analysis focus group interview data new graduate nurses nurse leaders seven canadian provinces resultsnew graduate nurses nurse leaders identified similar factors facilitate transition practice including formal orientation programmes unit cultures encourage constructive feedback supportive mentors impediments including unanticipated changes orientation length inadequate staffing uncivil unit cultures heavy workloads conclusionsthe results show new graduate nurses need access transition support resources nurse leaders often face organisational constraints able support new graduate nurses implications nursing managementorganisations ensure nurse leaders resources need support positive transition new graduate nurses including adequate staffing realistic workloads experienced new nurses nurse leaders work create unit cultures foster learning encouraging new graduate nurses ask questions seek feedback without fear criticism incivility
background possible serious bacterial infection pbsi major cause neonatal mortality worldwide studied risk factors psbi large rural population central india facility deliveries increased result government financial assistance program methods studied pregnant women singleton live born infants birth weight rural primary health centers around nagpur india using data population based maternal newborn health registry supported nichd global network women children health research factors associated psbi identified using multivariable poisson regression results two thousand one hundred twenty three infants psbi risk factors psbi included nulliparity parity compared parity first antenatal care visit trimester compared trimester administration antenatal corticosteroids low birth weight male sex lack early initiation breastfeeding conclusion infants low birth weight born mothers present late antenatal care receive antenatal corticosteroids born nulliparous women parity could targeted interventions delivery improve early recognition signs symptoms psbi prompt referral also appears need renewed focus promoting early initiation breastfeeding following delivery facilities
aim aim study assess influence custom fit mouthguards aerobic performance soccer futsal players material methods forty players brazilian clubs participated study athletes aerobic performance assessed meter shuttle run test athletes performed two tests without mouthguard two outcome variables analyzed total distance covered test meters maximum oxygen uptake max questionnaire assessing level acceptance mouthguards considering different parameters administered athletes delivery mouthguards weeks use questionnaire used visual analogue scale vas paired test used compare results obtained shuttle run tests questionnaires results mouthguards influence aerobic performance players considering total distance covered tests max stability parameter highest acceptance levels acceptance regarding breathing communication increased mouthguards usage communication lowest level acceptance considering parameters assessed players reported receiving recommendations use mouthguards playing football futsal none participants reported used mouthguards conclusions use custom fit mouthguards affect aerobic performance soccer futsal players future studies focus development appliances maximum protection minimum influence communication
stress affects well nursing students individuals work theory cognitive appraisal framework study proposed mind body self care strategies promote stress management stabilization emotions outcomes perception less stress mindful engagement environment objective study describe evaluation student perceived stress mindfulness hour per week class time dedicated mind body self care yoga mindful breathing reiki essential oil therapy quasi experimental study data collection took place time points participants entry level accelerated nursing students universities treatment group comparison group data included health promoting practices using health promoting promotion lifestyle profile control variable stress mindfulness perceived stress scale pss mindful attention awareness scale maas demographic information analysis using mixed design repeated measures analysis variances statistically significant interaction intervention time pss scores partial eta pss scores intervention group decreasing baseline intervention ended whereas pss scores comparison group increased baseline average scores maas differ significantly evaluation embedded mind body self care module first nursing course demonstrated promising improvements stress management findings support appropriateness integrating mind body self care content nursing curricula enhance students ability regulate stress
dimethyl fumarate dmf approved drug management relapsing multiple sclerosis despite efficacy dmf also reported challenging drug owing concerns like gastrointestinal tract flushing multiple dosing lower brain permeability less patient compliance economic hurdles present study aims develop dmf tocopherol acetate nanolipidic carrier nlcs enhance brain permeability improve gastric tolerance developed dmf tocopherol acetate nlcs offered average size pdi zeta potential higher drug entrapment drug loading assured controlled drug release behavior gastric intestinal cellular uptake studies caco syy monolayers confirmed better intestinal absorption neuronal uptake developed system corroborated pharmacokinetic biodistribution studies oral bioavailability enhanced times brain availability substantially improved vis vis plain drug findings promising offer preclinical evidence better brain availability dmf exploited better management diseases like multiple sclerosis
aim study investigate effect emotional mood states ability create effective primes using recently developed false memory priming paradigm negative positive mood state induced deese roediger mcdermott drm list presentation control group experienced mood induction participants presented compound remote associate task crat problems half primed previous drm lists whose critical lure solution crat problem results study showed induction negative mood state impaired recall critical lures also diminished effectiveness primes solving crat problems contrast positive mood control conditions false memory priming advantage evident higher proportion primed problems solved comparison primed findings discussed relation role affect semantic activation adaptive consequences false memories
men continue bear disproportionate accounts hiv diagnoses patient protection affordable care act aims address health care disparities recommending preventative services including hiv screening expanding community health centers increasing healthcare workforce study examined decision making physician primary care health providers provide hiv screenings quasi experimental design used estimate effects affordable care act provider initiated hiv screening national ambulatory medical care survey used examine hiv screening characteristic two time periods logistic regression indicated patient provider characteristics associated likelihood prescribed hiv screening non hispanic black men likely prescribed hiv screening compared non hispanic white men odds ratio confidence interval men see primary care providers likely prescribed hiv screening compared men seeing primary care provider men ages likely prescribed hiv screening compared men ages men ages likely prescribed hiv screening compared men ages health education programs identifying men increased risk contracting hiv may account increased screening rates certain populations future research examine age disparities surrounding adolescent young men hiv screening
purpose sought determine lower urinary tract symptoms associated incident falls community dwelling older men materials methods concord health ageing men project involves representative sample community dwelling men years old older defined geographic region sydney new south wales australia included analysis men without neurological diseases poor mobility dementia baseline lower urinary tract symptoms assessed using pss international prostate symptom score incontinence assessed using iciq international consultation incontinence questionnaire baseline pss subscores calculated storage voiding symptoms incident falls year determined telephone followup every months results pss storage voiding subscores associated falls urgency incontinence associated falls adjusted incidence rate ratio addition intermediate high pss storage subscores without urgency incontinence associated falls adjusted incidence rate ratio types incontinence urgency alone without urgency incontinence associated falls conclusions lower urinary tract storage voiding symptoms associated falls community dwelling older men symptoms overactive bladder urgency incontinence carried high risk falls storage symptoms also contributed fall risk independently urgency incontinence circumstances falls among men lower urinary tract symptoms explored understand lower urinary tract symptoms increase fall risk generate hypotheses regarding potential interventions furthermore trials treat lower urinary tract symptoms older men include falls end point
paper presents effective approach stabilizing nonlinear multiple time delay nmtd interconnected systems via composite genetic algorithm fuzzy controllers first neural network model employed approximate subsystem multiple time delays dynamics model converted linear differential inclusion ldi state space representation next terms lyapunov direct method delay dependent stability criterion derived guarantee exponential stability nmtd interconnected system subsequently stability condition criterion reformulated linear matrix inequality lmi due capability random search global optimization lower upper bounds search space set seek better feedback gains fuzzy controllers order stabilize quickly nmtd interconnected system based feedback gains via lmi based approach according improved genetic algorithm iga demonstrated better performance traditional robustness design fuzzy control synthesized stabilize nmtd interconnected system also achieve optimal infinity performance minimizing disturbance attenuation level
paper explores possibility utilizing novel means imaging establish system surveillance system may allow observation three dimensions activities within structures within earth oceans high frequency gravitational waves hfgws pass material little attenuation although absorbed polarization phase velocity causing refraction bending gws characteristics modified material object texture internal structure example change polarization passing material object discussed misner thorne wheeler specifically wave pulse backscatter cause shape polarization keep changing assertion need verified theoretically experimentally potential payoffs enormous applications technology include satellite based surveillance systems image subterranean weapons mass destruction wmds personnel interest inside behind buildings deeply submerged submarines hidden missiles rockets oil mineral deposits etc well acoustical surveillance laser interferometer gravitational observatory ligo interferometer detectors detect hfgws due hfgw short wavelengths discussed shawhan long wavelength gravitational waves thousand million meter wavelengths detected ligo practical surveillance value due diffraction resulting poor resolution short hfgw wavelengths meters fractions millimeter sensitivity hfgw generator detector system polarization angle changes yoctoradians radians could afford suitable resolution practical surveillance systems
rationale cystatin spink endogenous protease inhibitors epis mayplay key roles epithelial barrier function objectives investigate roles epis pathogenesis chronic rhinosinusitis crs methods examined expression cystatin spink nasal epithelial cells patients crs additionally vitro effects recombinant epis secretion epithelial derived cytokines thymic stromal lymphopoietin airway epithelial cells vivo effects recombinant epis nasal epithelium mice exposed multiple airborne allergens maa examined measurements main results compared control subjects patients noneosinophilic crs patients eosinophilic crs showed significantly lower protein mrna expression cystatin spink nasal epithelium allergen induced production thymic stromal lymphopoietin normal human bronchial epitheliakells inhibited treatment recombinant cystatin spink conversely production cytokines increased cystatin spink knocked small interfering rna chronic maa exposure induced goblet cell metaplasia epithelial disruption mouse nasal epithelium decreased tissue expression nasal lavage levels cystatin spink intranasal instillations recombinant epis attenuated maa induced pathology conclusions cystatin spink play important role protecting airway epithelium exogenous proteases preservation epis may therapeutic benefit intractable airway inflammation eosinophilic crs
efficient use water worldwide overriding importance due vital role life recently several countries suffered water scarcity mainly due population increase problems associated climate change change precipitation patterns world project mathematical programming model efficient sustainable use water parametric uncertainty proposed model considers rainwater harvesting includes catchment storage distribution alternative water source also considers sustainability aspects economic environmental points view maximizing revenue sales water minus cost production treatment maintaining desirable levels water natural reservoirs uncertainty result change precipitation patterns proposed model applied case study city morelia michoacan mexico considering time horizon years results show optimal schedule water storage distribution different sectors society public agricultural industrial users found use alternative water sources harvested rainwater along appropriate planning schedule storage distribution might help reduce pressure natural reservoirs even conditions uncertainty precipitation satisfying water demands city elsevier ltd rights reserved
pilots seasonal thermal energy storage solar energy local basis finland even international demonstrations show utilization level solar energy exceed annual local heat requirement similar climate zones study presents options heat electricity generation based local energy systems utilizing seasonal thermal energy storages energy needs production vartiosaari district helsinki finland explored case area project studied impacts introducing solar thermal energy local energy self sufficiency emissions heating energy supply excess solar heat summer stored using borehole thermal energy storage tank storage use winter around self sufficiency heat production would achieved scenarios studied addition carbon dioxide emissions could reduced around sulphur dioxide particulate emissions compared business usual situation elsevier ltd rights reserved
since communal violence erupted myanmar rakhine state buddhist muslim communities plight rohingya muslims received much media attention inside outside country rarely however get critical analyses reporting constructed research communal conflict journalism tends focus conflict sensitive reporting dangers employing local fixers interpreters whose influence seen reduce objectivity news rather actual news gathering strategies used specific conflicts based personal observations freelance reporter myanmar interviews journalists fixers working country article analyses news production processes reporting conflict article maps various actors involved production news foreign local journalists local producers fixers interpreters various challenges limitations face challenges function perpetuate familiar set reporting routines binary narratives consequences escalation perpetuation conflict
dynamics child abuse recognised global emerging social issue highly associated child humiliation government pakistan taken many initiatives addressing issues regarding child abuse neglect designed laws protect children exploitation abuse violence however enforced poorly implemented due lack proper definition child abuse related terms different ways reporting child abuse cases non governmental organisations ngos pakistan target extreme cases child sexual abuse child rape commercial sexual exploitation children cases physical psychological abuse reported ngos time proper surveillance system therefore required identify hidden cases types child abuse lead effective policy formulation implementation
aim explored whether cognitive performance verbal learning particular predicts psychosis psychiatric hospitalizations among unselected first admission adolescent patients general psychiatric care methods adolescents aged interviewed sips tested cognitive test battery beginning psychiatric treatment followed maximum years median years results composite factors processing speed verbal performance visuospatial performance predict psychosis cause psychiatric hospitalizations beyond psychosis risk symptoms however developed psychosis performed worse california verbal learning test cvlt compared adolescents lower scores cvlt immediate recall predicted psychosis per cvlt point decrease however general verbal ability adjusted cvlt reach significance conclusions impaired verbal list learning may predict psychosis also among adolescent psychiatric patients preselected psychosis risk suspicion
complex coupling environments difficult represent analytically signal flow graphs offer analysis method networks allowing network elements treated individually elements reintegrated ultimately analyzed using mason gain rule letter presents signal flow graph microstrip patch antenna simple coupling network often element large complex coupling networks comparisons results signal flow graph traditional transmission line model provided
semi active control system based use smart magnetorheological dampers control structural response wind turbine proposed herein innovative approach based implementation use variable properties base restraint able modify real time mechanical properties according instantaneous decision given control logic latter addressed control one structural response parameters smart base restraint thought combination smooth hinge elastic springs large scale adjustable dampers control algorithm instantaneously commands latter motion making modulate reactive force needed achieve performance goals design operation system shown reference case study consisting almost tall wind turbine realized scale model denmark technical university dtu shaking table tests performed action two different types wind loads using two purposely written control logics highlighting high effectiveness proposed control technique encouraging investigate direction
review presents overview pre clinical clinical issues contributed failures potential novel neuropsychiatric drugs prompted examination role animal models neuropsychiatric disorders advances basic neuroscience technology driven development animal models aspects neuropsychiatric disorders genetics environmental factors primary contributors development new animal models neuroimaging contributed search biomarkers neuropsychiatric disorders may identified differentiated progression monitored effects therapy assessed parallel theoretical practical advancements changes diagnosis classification neuropsychiatric disorders dsm dsm emergence nih initiatives matrics cntrics rdoc latter changes shifting concepts neuropsychiatric disorders away phenomenology biology thus aligning physiology psychology elsevier ltd rights reserved
aims assess association chronic tension type headache coexistent chronic temporomandibular disorder tmd pain severe limitations physical emotional functioning methods sample size estimation used determine case control study include subjects subjects suffering chronic tmd aged recruited routine clinical practice included subjects tmd pain associated chronic tension type headache cases tmd pain without history tension type headache controls clinical diagnosis tmd made according research diagnostic criteria tmd rdc tmd axis criteria clinical diagnosis headache made according international classification headache ichd rdc tmd axis criteria applied record scores graded chronic pain scale gcps symptoms checklist revised depression scl dep somatization scl som scales logistic regression analysis used assess relationship tmd pain chronic tension type headache high levels depression somatization severity scored scl dep scl som scales respectively high pain related disability gcps grade iii data adjusted take account age gender time since tmd pain onset chronic tmd pain intensity characteristic pain intensity results presence chronic tension type headache significantly associated severe scl dep odds ratio severe scl som high pain related disability conclusion study provides evidence associations clinical diagnosis chronic tension type headache coexistent chronic tmd pain key aspects physical emotional functioning reflected severe depression severe somatization high pain related disability
negative symptoms long conceptualized core aspect schizophrenia play key role functional outcome disorder management represents significant unmet need improvements definition characterization assessment instruments experimental models needed order foster research aimed developing effective interventions consensus recently reached following aspects five constructs considered negative symptoms blunted affect alogia anhedonia asociality avolition construct symptoms due identifiable factors medication effects psychotic symptoms depression distinguished regarded primary five constructs cluster two factors one including blunted affect alogia consisting anhedonia avolition asociality paper construct report current definition highlight differences among main assessment instruments illustrate quantitative measures available relationship evaluations based rating scales describe correlates well experimental models conclude assessment negative symptom dimension recently improved even current expert consensus based instruments diverge several aspects use objective measures might contribute overcome uncertainties reliability rating scales measures require investigation validation boundaries illness components particular neurocognition social cognition well defined without reducing heterogeneity within negative symptom dimension attempts develop successful interventions likely lead great efforts paid back small rewards
accurate sizing functions crucial efficient generation high quality meshes define sizing function often bottleneck complicated mesh generation tasks tedious user interaction involved present novel algorithm automatically create high quality sizing functions surface mesh generation first tessellation computer aided design cad model taken background mesh initial sizing function defined considering geometrical factors user specified parameters convex nonlinear programming problem formulated solved efficiently obtain smoothed sizing function corresponds mesh satisfying necessary gradient constraint conditions containing significantly reduced element number finally sizing function applied advancing front mesher aid walk algorithm efficient sizing value query scheme developed meshing experiments complicated geometry models presented demonstrate proposed sizing function approach enables accurate fully automatic surface mesh generation copyright john wiley sons ltd
language standards well ieee standard floating point arithmetic ieee std specify expected behavior binary decimal floating point arithmetic computer programming environments handling special values exception conditions many researchers focus verifying compliance implementations binary decimal floating point operations standards article concerned special values operands power function study standards define correct results operation propose mathematically justified definition correct results power function occurrence special values operands test different software implementations power function deal special values classify behavior different programming languages viewpoint much conform standards proposed mathematical definition present inconsistencies implementations standards discuss incompatibilities different versions software
people share knowledge cultural stereotypes social groups origins stereotypes examined whether stereotypes form spontaneously information repeatedly passed person person information novel social targets passed chain individuals initially began set random associations evolved system simplified categorically structured time novel stereotypes emerged increasingly learnable also allowed generalizations made previously unseen social targets illuminating cognitive social factors influence stereotypes form change findings show stereotypes might naturally evolve manipulated
performed three dimensional finite difference time domain fdtd simulations calculating microwave scattering metallic objects shielded plasma shroud simulations interest plasma based stealth technology simulations yield reasonable match experimental measurements physical interpretation also provided results terms flow electromagnetic power analysis possible using detailed spatio temporal evolution electromagnetic fields provided fdtd method find apart absorption bending waves toward regions lower plasma density plays important role determining extent backscatter major implications plasma stealth applications heretofore assumed plasma absorption main mechanism also bending could actually enhance radar scattering directions oblique incident direction also identified situations simulations become necessary situations composite one dimensional simulation may enough practical relevance since could help reduce demand computational resources modeling large objects like aircraft
background recently actigraphy studies bipolar disorders focused sleep rather daytime activity mania depression failed analyse mixed episodes separately furthermore even studies assessed activity parameters reported mean levels rather complexity predictability activity identified cases presenting one three acute phases bipolar disorder examined whether application nonlinear dynamic models description objectively measured activity used predict case classification methods sample comprised adults hospitalized acute episode mania bipolar depression mixed state agreed wear actiwatch continuous period mean level variability regularity entropy predictability activity recorded defined min active morning active evening period discriminant function analysis used determine combination variables best classified cases based phase illness results model identified two discriminant functions first statistically significant correlated intra individual fluctuation activity regularity activity sample entropy active morning period second correlated several measures activity evening period fourier analysis autocorrelation sample entropy classification table generated functions correctly classified cases based phase illness however bipolar depression cases misclassified manic phase conclusions findings treated caution small scale pilot study control prescribed treatments medication adherence etc however insights gained encourage widespread adoption statistical approaches classification cases alongside application sophisticated modelling activity patterns difficulty accurately classifying cases bipolar depression requires research unclear whether lower prediction rate reflects weaknesses model based actigraphy data reflects clinical reality possibility may one subtype bipolar depression
long term behavior dynamical system usually analyzed means basins attraction boa often particular cell mapping methods ensure straightforward technique approximation unfortunately construction boa requires large resources especially higher dimensional systems terms computational time memory space paper implementation cell mapping methods toward distributed computing undertaken new efficient parallel algorithm computation large scale boa presented herein also addressing issues arising inner seriality related boa construction cell mapping core thus wrapped management shell charge core administration permits split multicore environment computing domain carrying efficient use distributed memory proposed approach makes use double step algorithm order generate first multidimensional boa system evaluate arbitrary poincar sections hypercube stores information analysis test system performed considering different dimensional grids effort parallel implementation toward medium large clusters balanced great results terms computational speed performances strictly affected number cores used run code particular way instructed get best implementation massive parallel architecture processes must properly balanced memory operations numerical integrations significant improvement elaboration time large computing domain shown comparison serial code demonstrates great potential application advantages given use parallel reading writing also discussed respect boa grid dimension
paper wool yarns slenderized wool yarns used raw materials knitted process parameter many methods testing applied analysis wearing characteristics series experiments show significantly improvement anti pilling performance air permeability stiffness sample became smaller increasing soft comfort little effect crease resistance slenderizing improved spinning count also enhanced knitted properties structural transformation good choice develop high grade wool knitwear
context continues concern research addressing challenges practice faces benefit academia industry researchers need aware practitioners challenges context relevant applicable research undertaken objective paper investigates two research questions challenges agile practitioners face practitioner challenges manifest organisational setting aims map practitioner challenge landscape explore challenge characteristics compare findings previous literature identify implications research relevant practice method combination methods used elicitation practitioner challenges collected using challenge wall series practitioner events organisational case study using interviews document analysis observation online survey findings compared previous publications results challenges collected challenge wall grouped subthemes seven themes claims limitations organisation sustainability culture teams scale value investigating one challenge case study uncovered set new challenges inter related survey respondents experienced challenges highlighted case study conclusion landscape agile practitioner challenges complex intertwined challenges agile non agile environment multi dimensional affect many aspects practice may experienced simultaneously business organisational social adaptation problems challenges understanding cultural change measuring agile value persist hard address others adoption change focus time challenges governance contracts researched others business transformation researched findings expected impact researchers wishing address practitioner challenges need treat context rather isolation improve knowledge transfer elsevier rights reserved
nitric oxide donors known produce headache healthy well migraine subjects induce extracephalic cutaneous hypersensitivity rodents however little known effect nitric oxide donors cephalic cutaneous sensitivity combining behavioral immunohistochemical vivo electrophysiological approaches study investigated effect systemic administration nitric oxide donor isosorbide dinitrate isdn cephalic extracephalic cutaneous sensitivity neuronal activation within medullary dorsal horn mdh rat systemic administration isdn increased selectively first phase interphase facial formalin test effect hindpaw formalin one monitoring neuronal activity within mdh phospho erk immunoreactivity revealed isdn alone activate mdh neurons significantly increased number formalin evoked phospho erk immunoreactive cells ipsilateral contralateral mdh using vivo electrophysiological unit recordings show isdn administration never affected spontaneous activity trigeminal wide dynamic range neurons facilitated fiber evoked responses half neurons tested research demonstrates nitric oxide donor isosorbide dinitrate induces selectively cephalic hyperalgesia arises consequence central sensitization pain pathways subserve meningeal nociception model better mimics clinical condition offers another possibility studying role nitric oxide donor physiopathology headache ibro published elsevier ltd rights reserved
slope shaping important prevention recovery sediment disasters danger direct operation disaster scenes teleoperation efficient method slope shaping paper propose support system teleoperation slope shaping using construction robot system composed two sub systems augmented reality finishing stake system system evaluating finished shape deviation former system presents virtual finishing stake operator construction robot latter evaluation system measures actual shape slope presents deviation planned shape moreover developed multiple computer graphics patterns virtual finishing stake study first verified usefulness real finishing stake quantitatively via subjective experiments verified effectiveness proposed systems identified optimal pattern virtual finishing stake via experiments based results discuss usefulness finishing stake effectiveness system slope shaping using teleoperated construction robot
according schema therapy model maladaptive parenting styles interact child unique temperament development early maladaptive schemas emss turn increase one risk developing pathology however authors examined comprehensive model purpose study assess indirect effect perceived parenting styles depressive symptoms emss furthermore series moderated mediation analyses conducted examine whether indirect effect varies function temperament total undergraduate students completed measures perceived parenting experiences temperament emss depressive symptoms results indicated schema domains disconnection rejection impaired autonomy mediated relationship perceived parenting styles depressive symptoms moderation indirect effect found two twelve tested models study lends partial support schema therapy model also offers new way looking interactive nature constructs
aimsto examine association life time history insomnia hypersomnia compared sleep disturbance substance use patterns amounts substance use treatment episode designsecondary analysis data drug abuse treatment outcome studies conducted settingdata collected substance use treatment programs united states cities including short term patient long term residential methadone maintenance patient drug free treatment modalities participantsstudy samples included adults treatment entry months post treatment entry whose primary substance use entry alcohol cocaine heroin measurementslife time history insomnia hypersomnia assessed via self report type frequency substance use assessed treatment entry substance use also assessed months following treatment completion associations examined using linear logistic regression age sex race education level depression history treatment modality treatment substance use covariates findingslife time history insomnia hypersomnia neither reported participants respectively compared sleep disturbance life time insomnia hypersomnia associated treatment entry unique substance use patterns higher frequency substance use types sleep disturbance associated higher rates cocaine use month post entry odds ratios conclusionsthere evidence adverse association substance use sleep disturbance including higher frequency substance use substance abuse treatment higher rates cocaine use treatment episode
english speaking western cultures punitive attitudes towards law breakers well documented present study examines utility predictors punitive attitudes online survey data obtained convenience sample australian residents controlling demographic variables study examines utility two theoretical models crime distrust model racial animus model predicting punitive attitudes three factors crime distrust model significantly predict punitive attitudes study extends current literature identifying significance negative perceptions indigenous australians predicting punitive attitudes sentencing results suggest community perception indigenous australians significant predictor punitive attitudes addition factors crime distrust model future research using representative sample australian population recommended increase confidence findings interpreted
recognising australia need water management better supports urban populations facing increasing socio ecological challenges study article based brought together professionals sydney water sector understand believe entailed transitioning sydney water sensitive city participants called new institutional arrangements requiring collaboration leadership various levels government community groups individual community members adopt tainter model social complexification analytical framework considering implications research findings perspective model argue proposed arrangements would involve along envisioned benefits increasing complexity commensurate costs important consequences forms water sensitive cities might take considerations relating costs complexity take particular importance futures reduced material affluence appears increasingly possible costs complexity conditions may readily ameliorated via pathways entail increased local responsibility meeting water needs decentralised rainwater harvesting argue increased participation water related governance responsibility related infrastructure follow readily measures foster local enthusiasm mandated approaches require increased complexity elsevier ltd rights reserved
objectives create initiative change culture small community improve quality life relates health residents use health related educational sessions coordinated fitness nutrition program construction community fitness trails compared use health focused community driven program status quo seeking opportunities improve perception understanding one health overall quality life participants among various techniques identified improve community health outcomes dissemination information use educational sessions empowered citizens take control health status ultimately quality life came zero negative impacts providing education well participating sessions although application methods depends local resources leadership partnerships programs similar presented help improve quality life citizens communities across country facing challenges secondary sedentary lifestyle
better understanding risk factors major bleeding events anticoagulant treatment venous thromboembolism vte may help physicians deciding intensity duration treatment primary aim study identify risk factors major clinically relevant bleeding patients receiving oral factor inhibitor edoxaban warfarin treatment acute vte analysed data patients received dose study drug hokusai vte study bleeding risk factors evaluated patients received edoxaban significant variables combined prediction model used statistic estimate model discrimination bootstrap techniques internal validation major bleeding occurred patients given edoxaban patients given warfarin clinically relevant bleeding occurred respectively significant risk factors major bleeding edoxaban treatment female sex concomitant antiplatelet therapy haemoglobin mmhg discrimination model high statistic major bleeding lower clinically relevant bleeding statistic model applied patients receiving warfarin statistic conclusion identified five main predictors major bleeding patients receiving edoxaban treatment acute vte risk model based factors predicted increased risk bleeding good discrimination
objective study aimed define ethnographic composition assess health related quality life hrqol large population undocumented patients end stage renal disease esrd seeking emergent dialysis emergency department large public hospital united states design esrd patients presenting hospital main identified week consecutive enrollment period consenting patients completed two surveys ethnographic questionnaire validated kidney disease quality life kdqol instrument setting study conducted large county hospital dallas texas hospital recorded visits administered approximately dialysis treatments patients participants unfunded patients presenting study period consented participate resulting response rate patients undocumented immigrants main outcome measures quantitative scores subscales kdqol calculated study population results measures physical mental health study population lower published scheduled dialysis patients patients lost employment due dialysis requirements least study patients unaware required dialysis immigrating united states conclusions quality life scores found low among population undocumented emergent dialysis patients data also provide evidence availability dialysis cost primary driver illegal immigration esrd patients united states
background research suggests patients labeled beta lactam allergic able tolerate penicillins following assessment study aims define describe frequency true beta lactam allergy following allergy patient evaluation predominantly pediatric population methods primary care patients referred january june assessed suspected beta lactam allergy patient demographics history test results extracted electronic medical records testing performed based specialist recommendation following review patient history results study participants intradermal testing oral challenge given sample patients prior history beta lactam allergy advised could introduce beta lactam antibiotics following evaluation conclusions among patients documented beta lactam allergy recent history reaction low rate true beta lactam allergy consistent evaluation beta lactam antibiotic allergies reduce rates broad spectrum antibiotic prescribing among harmful consequences
autologous cells expressing chimeric antigen receptors cars specific demonstrated remarkable efficacy therapeutics cell malignancies present study generated flag tagged specific car cells flag compared non tagged counterparts effects solid hematological cancer cells vitro vivo solid tumors used hela cervical carcinoma cells engineered overexpress hela hematological cancer used raji burkitt lymphoma cells endogenously express like non tagged car cells flag car cells expanded culture fold exhibited potent cytolytic activity hela raji cells vitro flag car cells also secreted significantly ifn gamma control cells vivo flag car cells significantly blocked growth hela solid tumors increased tumor cleaved caspase levels expanded systemically flag car cells also significantly reduced raji tumor burden extended mouse survival results demonstrate strong efficacy flag tagged car cells solid hematological cancer models
rainwater harvesting roof considered valuable water resources material flow analysis mfa water mahasarakham university khamriang campus shows rainwater harvesting roof reduce water supply production save year water treatment cost sensitivity analysis suggests water supply conservation additional rainwater harvesting msu could enough water resources rainwater suitable substituted water gardening due convenience assemble ground storage tank pond store harvested rainwater roof current practice rainwater collected discharged drainage system treated wastewater treatment plant utilisation rainwater harvested could reduce wastewater amount must treated rainwater harvesting reuse promoted campus order encourage sustainable living water conservation policy
hydraulic circuits transfer remarkable amounts energy desired direction without taking large space implement technology harvesting energy wind appropriately models system required hydraulic wind power technology benefits eliminating expensive bulky variable ratio gearbox costly maintenance enabling integration multiple wind turbines single generation unit paper dynamics different hydraulic elements studied nonlinearities taken account pressure dynamics different parts system studied motor load effects considered based considerations novel nonlinear state space representation system introduced results mathematical model experimental data compared verify proposed model comparison demonstrated mathematical model captures major characteristics hydraulic circuit model system behavior different operating conditions
avian scavengers declining throughout world affected large number threats poisoning electrocution collision man made structures direct persecution changes agricultural practices landscape composition sanitary regulations reduce food availability formulate effective conservation strategies important quantify factors greatest influence demographic parameters territory occupancy breeding success whether quantitative models transferred across geographic regions political boundaries collated territory nest monitoring data endangered egyptian vulture neophron percnopterus balkans understand relative influence various factors population declines monitored occupancy different territories breeding performance territory monitoring years overall territory occupancy rate mean productivity fledglings per occupied territory examined different environmental variables influential explaining variation territory occupancy breeding success bulgaria greece tested whether models transferrable former yugoslav republic macedonia territory occupancy breeding success affected wide range environmental variables small effect may across political boundaries models reasonably good discriminative ability area receiver operated characteristic curve auc territory occupancy auc breeding success unsuccessful predicting occupancy breeding success external validation data set different country possibly influential factors vary geographically management focussing small number environmental variables unlikely effective slowing decline egyptian vultures balkan peninsula recommend short term reduction adult mortality enforcement anti poison laws long term adoption large scale landscape conservation programs retain restore historical small scale farming practices may benefit vultures biodiversity
research investigated application mhz microwaves pasteurizing pre packaged vegetables specially designed mhz single mode microwave assisted pasteurization map system used process carrot cuboids brine pre packaged polymer pouches gellan gel formulated selected model food simulate real foods processed map system heating patterns cold spots pouched samples detected chemical marker based computer vision method two map processes degrees min degrees min targeting clostridium botulinum type spores developed compared conventional hot water processes resulting equivalent microbial safety compared equivalent process map process greatly reduced total processing time reduced cook values improved quality uniformity products quality evaluation showed impacts map processing quality attribute carrot products depended specific quality parameter selected elsevier ltd rights reserved
present paper trial shed light indirect adaptive fuzzy logic controller idaflc concern proposed technique predestined two levels lower level based mamdani fuzzy controller hand upper level inverse model based takagi sugeno method output used adapt parameters fuzzy controller lower level moreover upper level contains learning mechanism adapt model identification parameters proposed idaflc implemented using arduino due kit practical results proved proposed adaptive controller ability adapt model identification parameters improves successfully performance response disturbance due load also measurement error sensor speed control motor
persistent organic pollutants like organochlorine pesticides continue contaminate large areas worldwide raising questions concerning management designed tested method link soil water pollution watershed galion river martinique first estimated risk soil contamination chlordecone referring past use land banana cultivation took soil samples sampled surface waters points groundwater points tested three hypotheses linked source chlordecone pollution watershed scale soils close river soils close sampling point iii throughout sub watershed generated sampling point graphical statistical analysis showed contamination river increased passed area contaminated plots decreased passed area contaminated chlordecone modeling showed entire surface area watershed contributed river pollution suggesting river mainly contaminated aquifers groundwater flows method proved reliable way identify areas polluted chlordecone watershed scale help stakeholders focus management actions hot spots whole watershed elsevier rights reserved
present research examined situational individual difference factors influence majority group observers evaluations witnesses responses incident bias study participants learned situation white person applying job need high low cost confrontation heard interviewer make racist comment white person confront non confrontation evaluated less appropriate confrontation costs confronting low costs high revealing high cost situation appropriate response bias ambiguous study focused high cost situation show evaluations another person responses bias depend individual differences observer values observers scored low universalism concern evaluated another person non confrontation appropriate confrontation participants scored high universalism concern perceived non confrontation less appropriate considering responses bias assessed helps illuminate normative processes affect confrontations bias outgroups contributing knowledge processes may allow biases persist elsevier ltd rights reserved
fuel consumption fossil based road vehicles significantly affected way vehicles driven true automated vehicles longitudinal control paper presents periodic servo loop longitudinal control algorithm adaptive cruise control acc system minimize fuel consumption car following scenarios fuel saving mechanism pulse glide png operation first discussed power train internal combustion engine step gear transmission servo loop controller designed based periodic switching map real time implementation adjusted range bounded feedback regulator enhance robustness model mismatch simulations uniform natural traffic flows demonstrate algorithm achieves significant fuel saving benefit automated car following scenarios naturalistic traffic flow coasting neutral gear compared linear quadratic controller meanwhile intervehicle range preferably bounded negative impact safety traffic smoothness contained
rise affordability quality video production equipment resulted increased interest video mediated tests foreign language listening comprehension although research tests continued fairly steadily since early studies relied analyses raw scores despite growing prevalence item response theory field language testing whole present study addresses gap comparing data identical counter balanced multiple choice listening test forms employing three text types monologue conversation lecture administered university students english japan data analyzed via many facet rasch modeling compare difficulties audio video formats investigate interactions format text type format proficiency level identify specific items biased toward one format finally items displaying differences subjected differential distractor functioning analyses interactions format text type format proficiency level observed four items discovered displaying format based differences difficulty two found correspond possible acting anomalies videos author argues work focusing item level interactions test format
agent technology currently considered important approach developing intelligent manufacturing systems offers new way thinking many classical problems manufacturing engineering multi agent based approach solving part allocation problems flexible manufacturing systems fms presented easily cope dynamic environment four agents involved carrying tasks allocating parts different machines communicator machine part material handling device mhd upon arrival manufacturing facility part informs communicator agent task requirements communicator agent divides task subtasks sends call bids message machine mhd agents machine responds accordance process capabilities buffer limit response may whole task one subtasks contains price cost details subtasks along performance index acceptance ratio machine final allocation made based objective function includes processing transportation costs time algorithm presented used communicator agent allocating parts different machines illustrative example given solve task allocation five machines machine different performance index acceptance ratio
introduction accuracy cerebrospinal fluid csf biomarkers detecting alzheimer disease pathology fully validated autopsied nonamnestic dementias methods retrospectively evaluated csf amyloid beta phosphorylated tau amyloid tau index predictors alzheimer pathology patients primary progressive aphasia frontotemporal dementia progressive supranuclear palsy results nineteen nonamnestic autopsied cases relevant csf values included autopsy nine non pathologies six patients whose combined csf phosphorylatedtau amyloid levels consistent postmortem alzheimer pathology two patients whose biomarker values consistent non pathologies csf values remaining eight non cases conflicting borderline ranges discussion csf biomarkers reliably identified alzheimer pathology nonamnestic dementias may useful screening measure inclusion nonamnestic cases alzheimer trials alzheimer association published elsevier inc rights reserved
previous burnup calculations high conversion water reactor hcwr options given promising fuel cycle results safety must assessed requires development academic computing tools coupling simply possible neutronics thermal hydraulics diffusion based nodal drift method ndm spatial core analysis developed towards broad coarse safety review promising candidates ndm already validated simplified candu loca benchmark without thermal coupling dedicated calculation rod ejection accident rea defined recent pwr like mini core benchmark present work describes validates necessary enhancements ndm first geometry coupling lumped thermal model validated features including refined model ejected control rod added particular attention paid analysis discrepancies reference results limitations due oversimplified lumped thermal model finally discussed elsevier ltd rights reserved
public auditing protocol significant implementing secure cloud storage since used check integrity data stored cloud without downloading recently zhang dong presented identity based public auditing ibpa protocol using bilinear pairing claimed protocol provably secure random oracle model proposing two concrete attacks demonstrate adversary zhang dong protocol break data integrity without found auditor analysis shows protocol secure cloud storage elsevier inc rights reserved
study analyses presence gender segregation spanish exporting firms women access managerial positions vertical segregation women achievement managerial roles socially associated communal attributes horizontal segregation tested argue boundary spanning henceforth boundary management export interfirm relationships benefits relational communal skills therefore could offer opportunity women gain access management positions also put risk falling rut achieving control based managerial roles empirical study examines characteristics personal firm level spanish female managers charge export management independent channels multivariate analysis performed compare female managers male managers boundary management position finance director control position closer socially stereotyped masculine role results show women slightly higher access boundary management jobs finance management jobs well significantly lower promotion time male colleagues also corroborate smaller percentage women men management positions female managers working younger firms fewer resources export activity aedem published elsevier espana
paper describes new approach design proportional integral derivative pid controller longitudinal airflow velocity road tunnels fire situations work shows clearly use proper model provides valid data model based tuning tunnel controllers demonstrated real tunnel tests design uses simplified mathematical model airflow dynamics based bernoulli continuity equations describe airflow dynamics one dimension optimizing controller parameters site time consuming problem increases case complex tunnels several entrance exit ramps typically occurrences traffic congestion approach based design controller simulations use mathematical model airflow velocity tunnel approach spares lot work time controller tuning within tunnel tests moreover discover potential problems occur real instances fire tunnel additional advantage approach possibility simulate scenario errors failures devices important reliable control longitudinal airflow velocity although approach focused primarily complex road tunnels due complexity significant time savings controller tuning also used simpler tunnels ramps usually highway tunnels design airflow controller complex compared case road tunnels paper also includes case study airflow controller design blanka tunnel complex prague czech republic largest city tunnel central europe elsevier ltd rights reserved
targeting non native ligand binding sites potential investigative therapeutic applications attractive strategy proteins share common native ligands rab protein rab subfamily member rab proteins members ras gtpase superfamily ras gtpase superfamily members bind native ligands gtp gdp switch proteins respectively rab physiologically essential autophagy transport endoplasmic reticulum golgi apparatus pathologically rab implicated human cancers neurodegenerative disease cardiomyopathy bacteria caused infectious diseases performed structural analyses rab protein using unique ensemble clustering methods including multi step principal component analysis non negative matrix factorization independent component analysis better identify representative rab proteins application single clustering method alone used identified representative rab structures resolved multiple ligand states map known novel binding sites report least novel binding site rab involving rab specific residues could explored rational design development investigative probes therapeutic small molecules rab protein proteins wiley periodicals inc
paper presents embedded signal analyzer impedance identification pem fuel cell fluctuation signal current injected stack key part analyzer analog signal processing unit designed special consideration analog signal processing unit capability extracting small fluctuation signals current voltages stack cell phase delays caused analog circuit designed avoid complicated phase calibration original signals experiment performed validate functions proposed signal analyzer
building integrated photovoltaic bipv windows provide benefits generating electricity reducing building cooling heating energy consumption efficiently utilizing daylight simultaneously paper overall energy performance double skin facade dsf insulating glass unit igu studied comparative experiments test rig hong kong dsf means ventilated dsf default special mentioned found average solar heat gain coefficients shgcs dsf igu values results indicate dsf better performance igu reducing solar heat gains worse performance regarding thermal insulation lower module temperature energy conversion efficiency dsf better igu simulation models dsf igu developed validated experimental data using validated models overall energy performances dsf igu five different climates china investigated results show average energy saving potential dsf igu respectively compared commonly used insulating glass window five different climates average performance igu better performance ventilated dsf five representative cities however appropriate ventilation control scheme adopted dsf much better performance igu models developed study used selecting suitable windows design process results achieved used guideline utilizing windows different climates elsevier ltd rights reserved
ambient assisted living aal ambient intelligence ami try achieve future technology surrounds users helps daily lives sense urgent need solutions cover rapid increase elderly population chronic diseases led increase projects related aal ami latest years several projects proposed tackle different medical problems building devices others services paper presents igenda evolution useraccess main objective developing aal platform features analysis latest developments points future directions work projects display importance interoperability platforms demonstrating case study aal development
chronic hepatitis virus hcv infection causes severe liver disease affects million individuals novel directly acting antivirals targeting hcv revolutionized treatment however high costs limit access therapy recently several related drugs used humans treat allergies neuroleptics emerged potent hcv cell entry inhibitors insights antiviral modes action may increase opportunities drug repurposing hepatitis possibly important human viral infections
energy management adapted optimization production consumption fossil fuels simple solutions possible reduce total cost bound fuel production costs investment consequently reduction emission less production less emission based quality energy control energy energy management satisfy demand maintaining equal balance equation sigma total cost sigma feasible controllable case optimization allows saving energy research lies withn scope environmental search solutions optimizations energy electrical supply network obligation reduce emission indeed among main solution research integration renewable resources energy independence sustainable development pushes consider energy problem according economic point view also according ecological point view encouraged develop systems energy basis distributed generation large scale including understanding renewable energy high output solutions energetic
alzheimer disease representative age related neurodegenerative disease could result loss memory cognitive deficiency however precise onset time alzheimer disease affecting neuronal circuits mechanisms underlying changes clearly known address neuroanatomical changes early pathologic developing process acquired neuronal morphological characterization app double transgenic mice using micro optical sectioning tomography system reconstructed neurons datasets resolution used sholl method analyze anatomical characterization dendritic branches results showed similar progressive change amyloid plaques number dendritic branches significantly decreased month old mice addition distinct reduction dendritic complexity occurred third fourth order dendritic branches month old mice significant changes identified parameters month old mice branch level density distribution dendritic arbors radial direction decreased range neuron soma month old mice changes dendritic complexity suggest reductions contribute progressive cognitive impairment seen app mice work may yield insights early changes dendritic abnormality relevance dysfunctional mechanisms learning memory emotion alzheimer disease elsevier inc rights reserved
objectiveto conduct systematic review meta analysis studies measured cytokine chemokine levels individuals major depressive disorder mdd compared healthy controls hcs methodthe pubmed medline embase psycinfo databases searched may effect sizes estimated random effects models resulteighty two studies comprising participants mdd hcs met inclusion criteria peripheral levels interleukin tumor necrosis factor tnf alpha soluble receptor chemokine ligand receptor antagonist soluble tnf receptor elevated patients mdd compared hcs whereas interferon gamma levels lower mdd hedge levels soluble receptor sil ccl transforming growth factor beta significantly altered individuals mdd compared hcs heterogeneity large sources heterogeneity explored age smoking status body mass index conclusionour results characterize cytokine chemokine profile associated mdd future studies warranted elucidate sources heterogeneity well biosignature cytokines secreted immune cells
work reported proteolytic extract prepared maclura pomifera latex employed hydrolyze bovine caseins densitograms tricine sodium dodecyl sulfate polyacrylamide gel electrophoresis sds page indicated caseins considerably degraded min reaction degree hydrolysis determined trinitrobenzenesulfonic acid method min digestion concentration small peptides increased hydrolysis time analysis reverse phase high performance liquid chromatography hplc mass spectrometry revealed virtually unchanged peptide profile results suggested proteases highly specific certain peptide bonds cleaved hydrolysate min displayed highest inhibition angiotensin converting enzyme ace showing analysis peptide fractionation hydrolysate hplc exhibited two peaks responsible activity fragmentation analysis use iterated matrix assisted laser desorption ionization time flight mass spectrometry maldi tof tof aid bioinformatics tools enabled deduce two peptide sequences one yqepvlgpvrgpfpiiv previously reported ace inhibitor rffvapfpe yet undescribed presence bioactive peptides casein hydrolysates argues potential use development functional foods elsevier ltd rights reserved
nearctic moth acontia candefacta lepidoptera noctuidae expanding range europe species considered successful agent biological control ambrosia artemisiifolia asterales asteraceae weed whose pollen causes allergies humans additional findings moth recorded several new sites southeastern europe serbia using light trapping present discuss current distribution moth europe paths spreading basis gis data gis technology used map distribution quantify values environmental variables within range analysed moth species additionally potential colonization moth across europe modelled basis current distribution environmental variables host plant distribution
steroid hormones use formore half century contraceptive agents researchers elucidating biochemical mechanisms action non target effects progesterone synthetic progestins critical women health internationally appear important effects immune functioning diverse systems apart fromthe contraceptiveworld separate field devoted understanding progesterone contexts based research following development timeline parallel hormonal contraception progesterone hydroxyprogesterone caproate administered prevent pretermbirth high risk pregnantwomen pretermbirth researchers similarly working determine precise biochemical actions immunological effects progesterone progesterone research areas could benefit increased collaboration bringing two bodies literature together progesterone actions various hormone receptors lifelong importance different organ systems researchers much learn molecule combination existing literatures future studies build combined knowledge base
challenging strategy reuse printer structures laboratory training related automation positioning presented laboratory course meant presented students within digital systems microcontrollers automatisms control courses
green roof substrates usually designed achieve desirable characteristics low bulk density preparation cost high water holding capacity whc hydraulic conductivity airfilled porosity afp however importance given sorption capacity leaching potential substrate thus present study novel attempt made incorporate brown seaweed turbinaria conoides growth substrate enhance runoff quality green roofs green roof substrate prepared using perlite vermiculite sand crushed brick cocopeat conoides found favourable characteristics low bulk density high whc afp aid flow fixed column sorption capacity green roof substrate towards various metal ions examined results indicated column able operate min flow rate min outlet concentration reached inlet green roof experiments performed using pilot scale assemblies portulaca grandiflora vegetation rainfall simulations observed vegetated green roof assemblies acted sink various metal ions produced better runoff addition green roofs buffered acidic rain delayed runoff generation elsevier rights reserved
objectives objective study identify psychosocial predictors comorbid eating disorders eds individuals type type diabetes methods cross sectional study people diabetes answered online survey covering sociodemographic information body esteem restrictive eating medication omission coping styles depressive symptoms participants recruited advertisements websites including forums community organizations facebook groups focusing either diabetes eds recruitment took place canada europe australia united states results average eds developed diabetes diagnoses participants type diabetes prior diabetes diagnosis participants type diabetes type diabetes avoidance coping styles depressive symptoms predicted additional diagnosis eds occurring eds type diabetes predicted body mass indexes task oriented coping strategies conclusions variables potentially influencing development eds people diabetes differ according type diabetes body mass indexes coping styles depressive symptoms systematically evaluated closely monitored context diabetes management prevention strategies onset based increased knowledge risk factors associated eds necessary could help decrease risk health complications diabetes canadian diabetes association
objectives proposal implementation computational framework quantification structural renal damage dimercaptosuccinic acid dmsa scans aim work propose implement validate computational framework quantification structural renal damage dmsa scans observer independent manner materials methods set pediatric dmsa positive scans matched controls using expert guided automatic approaches set image derived quantitative indicators computed based relative size intensity histogram distribution lesion correlation analysis conducted order investigate association indicators clinical data interest scenario including reactive protein crp white cell count vesicoureteral reflux fever relative perfusion presence renal sequelae month follow dmsa scan results fully automatic lesion detection segmentation system able successfully classify dmsa positive negative scans auc sensitivity specificity image computed relative size lesion correlated presence fever crp levels measurement derived distribution histogram lesion obtained significant performance results detection permanent renal damage auc sensitivity specificity conclusions proposal implementation computational framework quantification structural renal damage dmsa scans showed promising potential complement visual diagnosis non imaging indicators elsevier espafia semnim rights reserved
heuristic procedure based novel recursive formulation sinusoid rfs regression predictive least squares enables decompose uniformly nonuniformly sampled signals sparse set sinusoids sss optimal sss found levenberg marquardt optimization rfs parameters near optimal sinusoids combined common criteria estimation number sinusoids embedded noise procedure estimates cardinality parameters sss proposed algorithm enables identify rfs parameters sinusoid data sequence containing fraction cycle extreme cases frequency sinusoid approaches zero algorithm able detect linear trend data also irregular sampling pattern enables algorithm correctly reconstruct sampled sinusoid parsimonious nature obtaining models opens possibilities using proposed method machine learning expert intelligent systems needing analysis simple representation signals properties proposed algorithm evaluated examples irregularly sampled artificial signals noise compared high accuracy frequency estimation algorithms based linear prediction approach particularly respect cramer rao bound crb elsevier ltd rights reserved
objectives sacral nerve stimulation sns fda approved intervention spectrum conditions women childbearing age pregnant constitute fair number sufferers overactive bladder symptoms nonobstructive urinary retention however hypothesized effects sns fetus mother device limit use group patients present literature review support possible safety sns pregnancy materials methods reviewed number animal studies effects neuromodulation myometrial activity fetal abnormalities several case reports series describing continued sns well related modes neuromodulation gestation reported effects mother fetus device results studies female mammals showed neurostimulation myometrial tissue aided embryo transfer increased latency evidence inducing preterm labor follow pregnant rats showed effects mothers offspring reviewed cases adopted interrupted uninterrupted courses sns delivery almost pregnancy complications infants healthy birth delivered electively caesarean section close term one follow infants reported health issues though sns concluded cause device replacement delivery occasionally performed different reasons conclusion negative effects sns fetus mother device significantly reported literature studies expanding data literature could place sns therapy pregnancy way declaration safe practice
combination analytic individual group psychotherapy indicated patients suffering borderline personality disorder due lack experience triangulation tendency split objects absolutely good bad partial objects patient develops negative image one therapist represented good enough work negative relationship precondition practice therapists exchange conflicting feelings owing different countertransference order integrate splitted partial objects
compelling evidence teachers clergy stressful occupations study aimed compare rate job strain burnout among lay consecrated teachers study effect religious coping mental health two groups cross sectional survey study carried catholic kindergarten preschool primary schools italian congregation nuns south italy italian versions maslach burnout inventory educator survey mbi scale general health questionnaire ghq study specific questionnaire sociodemographic variables indicators subjective self reported religiosity objective prayer personal church attendance religiousness used data analyzed according guidelines data processing analysis scales used participation rate study significant difference two groups religiousness job strain burnout scores lay teachers affected group moreover religiousness scores positive correlation personal accomplishment job satisfaction perceived performance negative correlation emotional exhaustion turnover intention morbidity psychiatric therefore according religious coping research prayer personal church attendance recommended two ways prevent job strain burnout teacher work
background microbial genomes national center biotechnology information ncbi represent large collection assemblies several complexities associated data great variation sampling density since human pathogens densely sampled bacteria less represented different protein families occur annotations different frequencies quality genome annotation varies greatly order extract useful information sophisticated data analysis needs performed multiple levels phylogenomic resolution protein similarity adequate sampling strategy results protein clustering used construct meaningful stable groups similar proteins used analysis functional annotation approach create protein clusters three levels first tight clusters groups closely related genomes species level clades constructed using combined approach takes account sequence similarity genome context second clustroids conservative clade clusters organized seed global clusters finally global protein clusters built around seed clusters propose filtering strategies allow limiting protein set included global clustering clade clustering procedure subsequent selection clustroids organization seed global clusters provides robust representation high rate compression seed protein clusters extended adding related proteins extended seed clusters include significant part data represent major known cell machinery remaining part coming either non conservative unique rapidly evolving proteins rare genomes resulting low quality annotation group together well processing proteins requires significant computational resources results large number questionable clusters conclusion developed filtering strategies allow identify exclude peripheral proteins limiting protein dataset global clustering overall proposed methodology allows relevant data different levels details obtained data redundancy eliminated keeping biologically interesting variations
dissociation involves disruptions usually integrated functions consciousness perception memory identity affect depersonalization derealization numbing amnesia analgesia precise neurobiological underpinnings dissociation remain elusive neuroimaging studies disorders characterized high dissociation depersonalization derealization disorder ddd dissociative identity disorder dissociative subtype post traumatic stress disorder ptsd provided valuable insight brain alterations possibly underlying dissociation neuroimaging studies borderline personality disorder bpd investigating links altered brain function structure dissociation still relatively rare article provide overview neurobiological models dissociation primarily based research ddd ptsd based background review recent neuroimaging studies associations dissociation altered brain function structure bpd studies discussed context earlier findings regarding methodological differences limitations concerning possible implications future research clinical setting
traditionally assumed requirements specification product requirements engineering high impact ensuing software development stages therefore knowledge management used construct requirements specification performed structured manner discover analyze understand data information knowledge chain tacit explicit interested parties possess article results literature review presented seeking answer following questions meaning knowledge requirements engineering approaches proposed manage knowledge requirements engineering efficiency efficacy knowledge management models evidenced requirements engineering thirty six works chosen analysis total found search analysis showed knowledge central significance stage authors yet agree best methods impart apply knowledge general framework emerged validated approach manage knowledge requirements engineering evaluation marks model efficiency efficacy low consisting mostly personal interpretations elsevier ltd rights reserved
public private insurers implementing payment mechanisms improve coordination reduce cost drug hospital ancillary services cancer patients target unnecessary hospitalization others create incentives prescribing lower cost chemotherapies biologics physician payment methods oncology require balance incentives cost control incentives patient access expensive specialty drugs none initiatives adopt bundled methods concern shifting excessive financial risk onto physicians context rapid pharmaceutical innovation contexthigh value oncology requires physicians monitor coordinate aspects care educate engage patients adopt cost effective drug treatments however oncology practices united states traditionally reimbursed based number office visits performed cost plus margins prescription expensive drugs public private payers experimenting methods payment include monthly care management fees annual bonuses incentives conservative choice among alternative drug regimens methodsthis paper uses case study methods examine oncology payment initiatives medicare anthem aetna unitedhealthcare nation largest public private health insurance plans findingsthe insurers supplement traditional fee service payment payment methods designed promote coordination care conservative use health care resources medicare aetna unitedhealthcare reward oncology practices reduce per patient spending targeting unnecessary patient visits emergency departments hospitals anthem offers monthly payments practices adhere lower cost drug treatment pathways aetna increases percentage markup low cost generic chemotherapies high cost biologics unitedhealthcare removes linkage physician payment spending office infused drugs condition receiving new payments initiatives requires participating practices report cases improve performance quality metrics none initiatives bundles payment oncology drugs together payment oncology services concern shifting financial risk onto physicians creating access barriers patients conclusionsthe emerging value based methods oncology payment supplement fee service cost based reimbursements per month per episode payments none payers bundle spending cancer drugs payments services payers recognize bundled payment could create access barriers patients undermine innovation effective expensive new pharmaceuticals
crop simulation models commonly used forecast performance cropping systems different hypotheses change use regional scale generally constrained however lack information spatial temporal variability environment related input variables soil agricultural practices sowing dates influence crop yields satellite remote sensing data shed light variability providing timely information crop dynamics conditions large areas paper proposes method analyzing time series modis satellite data order estimate inter annual variability winter wheat sowing dates rule based method developed automatically identify reliable sample winter wheat field time series infer corresponding sowing dates method designed case study camargue region france winter wheat characterized vernalization temperate regions detection criteria chosen grounds agronomic expertise analyzing high confidence time series vegetation index profiles winter wheat automatic method identified target crop four year average cultivated areas low commission errors also captured seasonal variability sowing dates errors days cases respectively extending analysis years showed sowing camargue usually done around november days comparing inter annual sowing date variability main local agro climatic drivers showed type preceding crop weather conditions summer season wheat sowing prominent role influencing winter wheat sowing dates elsevier rights reserved
study fractional order model hiv infection latent helper cells included compute reproduction number model study stability disease free equilibrium observe reproduction number varies order fractional derivative terms epidemics suggests varying induces change patients epidemic status moreover simulate variation relevant parameters fraction uninfected cells become latently infected ctls proliferation rate due infected cells model produces biologically reasonable results elsevier rights reserved
paper analytical method designing proportional integral derivative pid controllers based laguerre orthonormal functions presented pid controller parameters calculated matching first three coefficients laguerre series open loop gain ideal one reach goal plant pid controller ideal open loop gain transfer functions represented terms corresponding laguerre series pole laguerre basis function could appropriately selected assure closed loop stability moreover optimum value parameter determined reach best fitting desired step response considering control signal constraint simulation results experimental tests servomotor system given show effectiveness proposed method
solar energy one promising renewable energies meaningful sustainable development energy source multi segment plate concentrated photovoltaic cpv solar power system proposed paper design principle multi segment plate concentrator solar power system given could provide uniform solar radiation flux density distribution solar cells prototype multi segment plate cpv solar power system developed experimental study aiming investigations solar radiation flux density distribution performances concentrator design experimental results showed solar radiation flux density distribution provided multi segment plate concentrator good uniformity number temperature solar cells influence photoelectric transformation efficiency cpv solar power system elsevier ltd rights reserved
background limited data available regarding reproducibility lactulose fructose breath testing clinical application functional bowel disorders objectives purpose study investigate reproducibility lactulose fructose breath hydrogen testing assess symptom response fructose testing methods results analysed patients functional bowel disorder lactulose breath tests fructose breath tests completed another test weeks later oro caecal transit time hydrogen responses qualitatively positive negative quantitatively area curve auc hydrogen compared tests another patients data scores overall abdominal symptoms abdominal pain bloating wind nausea fatigue collected fructose test compared hydrogen responses results correlations found lactulose auc linear regression transit time spearman tests significant proportion lost presence fructose malabsorption conclusions routine use lactulose fructose breath tests functional bowel disorder patients supported due poor reproducibility low predictive value symptom responses
paper use data general social survey fbi uniform crime reporting statistics sources consider differences attitudes punishment among four groups black men black women white men white women well differences vary according county crime rates centering expectations group specific attitudes within conflict theory prior empirical findings guided presumption race gender cultural categories shape attitudes punishment influencing interactions criminal justice system meaning cultural categories varies context analyses provide evidence race gender context interact shape attitudes punishment overall research improves understanding group differences punitive attitudes cultural context system incarceration operates elsevier inc rights reserved
many maritime accidents caused human error including things inadequate watch keeping mistakes ship handling also new navigational equipment developed using information technology technology provide various kinds information safe navigation despite efforts reduction maritime accidents occurred degree expected navigational equipment provides much information information well organized users feel complicated rather helpful point view method representation navigational information important quantity information research required representation information make information easily understood allow decisions made correctly promptly paper adopt augmented reality technologies representation information computer graphics technology blends virtual reality real world recently technology widely applied daily lives provide information effectively users therefore propose new concept navigational system based technology review experimental results ship handling simulator open sea test verify efficiency proposed system
non randomized studies aim reveal whether interventions effective real life clinical practice growing interest including evidence decision making process evaluate existing methodologies present new approaches using non randomized evidence network meta analysis randomized controlled trials rcts aim assess relative treatment effects first discuss assess compatibility two types evidence present compare array alternative methods allow inclusion non randomized studies network meta analysis rcts naive data synthesis design adjusted synthesis use non randomized evidence prior information use three level hierarchical models apply methods two previously published clinical examples comparing percutaneous interventions treatment coronary stent restenosis antipsychotics patients schizophrenia discuss depth advantages limitations method conclude inclusion real world evidence non randomized studies potential corroborate findings rcts increase precision enhance decision making process copyright john wiley sons ltd
paper presents innovative solution based time flight tof video technology motion patterns detection real time dynamic hand gesture recognition resulting system able detect motion based hand gestures getting input depth images recognizable motion patterns modeled basis human arm anatomy degrees freedom generating collection synthetic motion patterns compared captured input patterns order finally classify input gesture evaluation system significant collection gestures compiled getting results pattern classification well comparison results using information
heat shock proteins hsps essential cell survival function protein chaperones role play kidney health disease varied hsp induction may either beneficial detrimental kidney depending specific hsp type cell context review addresses role hsps kidney including development osmoprotectants various kidney disease models heat shock transcription factor activated stress renal cells induces hsp elaboration separately regulates immune responses contribute renal injury induced hsps intracellular compartment mostly beneficial kidney stabilizing restoring cell architecture function acting protein chaperones intracellular hsps also inhibit apoptosis facilitate cell proliferation preserving renal tubule viability acute injury enhancing progression cystic kidney disease malignancy induced hsps extracellular compartment either circulating located outer cell membranes mainly detrimental enhancing inflammation pathways injury correctly harnessing stress proteins promises opportunity alter course acute chronic kidney disease
propose two stage mixed integer linear stochastic optimization model analyze scheduling electricity production units natural gas supply uncertainty due pipeline congestion natural gas price variability first stage stochastic optimization model represents day ahead scheduling unit commitment stage second stage represents actual real time operations number scenarios use model analyze effect unit commitment dispatch two types natural gas supply conditions first analyze case involving low cost natural gas supply natural gas transmission issues related potential gas pipeline congestion examine case involving higher cost natural gas used solely attain feasibility fast ramping events first case mimics situations iso new england system relatively low cost natural gas supply uncertain cold weather conditions due natural gas transmission bottlenecks second case reminiscent situations california iso system relatively expensive flexible natural gas fired units need used handle rapid changes net demand early mornings late afternoons
introduction accurate discrimination another person eyegaze direction vital provides cue gazer focus attention turn supports joint attention patients schizophrenia shown direct gaze bias judging gaze direction however current tasks dissociate early perceptual bias high level top effects investigated early stages gaze processing schizophrenia measuring perceptual sensitivity fine deviations gaze direction cone direct gaze codg ability reflexively orient locations cued deviations methods twenty four patients controls completed codg discrimination task used realistic direct face images six fine degrees deviation pixels left right direct gaze gaze cueing task assessed reflexive orienting fine grained deviations results data showed patients exhibited impairment gaze discrimination observe reduced orienting response conclusions results suggest patients may suffer deficits associated interpreting another person gaze earliest processes concerned detecting averted gaze reflexively orienting gazed location intact
paper deals thermodynamic analysis absorption refrigeration cycle used cool temperature intake air internal combustion engine using heat source exhaust gas engine solution ammonia water selected due stability wide range operating temperatures pressures low freezing point effects operating temperatures pressures concentrations strong weak solutions absorption refrigeration cycle examined achieve proper heat rejection ambient potential increasing internal combustion engine efficiency reduce pollutant emissions estimated means theoretical models experimental tests order provide boundary conditions absorption refrigeration cycle simulate effect engine performance thermodynamic model used reproduce engine performance intake air cooled furthermore detailed experimental work carried validate results real engine operation theoretical results show absorption refrigeration system decreases intake air flow temperature temperature around degrees even lower using bottoming waste heat energy available exhaust gases wide range engine operating conditions addition theoretical analysis estimates potential strategy increasing engine indicated efficiency levels also operating conditions evaluation finally predicted benefit engine indicated efficiency experimentally confirmed direct testing elsevier ltd rights reserved
data presented describing refined simulations perturbation growth three layer cylindrical liner system tested disk explosive magnetic flux compression generators demgs study strength properties copper polyethylene shocklessly applied pressures similar gpa calculated performance liner system experiments study strength properties copper shockless loading similar gpa pressures presented feasibility similar strength experiments quasi isentropic material compression similar gpa using demgs demonstrated
objective review literature training clinicians person perception accuracy ability correctly judge patients states traits present importance training skill share evidence trainable skill suggest evidence based recommendations implementing training methods conducted literature review person perception training studies developed implemented clinicians also summarized measures evaluate training efficacy barriers implementation future research directions results training studies exist improve clinicians ability perceive patients emotions pain distress depression varied training approach length training study design ten studies showed training benefited person perception accuracy conclusions medical literature previous meta analysis person perception training across contexts demonstrate training person perception accuracy effective examples effective trainings provide suggestions best practices future efforts area practice implications evidence needed create implement trainings produce differences accuracy also patient care outcomes medical curriculum developers researchers collaborate create effective person perception trainings clinicians published elsevier ireland ltd
depression anxiety multiple sclerosis linked severe course disease higher numbers relapses addition poorer treatment adherence exacerbated immune system dysregulation recent investigations indicate psychotherapeutic interventions stress management mindfulness based interventions mbis could improve quality life depression anxiety fatigue patients mindfulness fosters ability slow observe experiences truly improves affect regulation mindfulness acquired training advantage psychotherapeutic interventions effects may remain time since cultivating mindfulness depends regular practising abilities learned training objective article review current evidence psychotherapeutic psychosocial interventions including mbis stress management beneficial effects patients sociedad espanola neurologia published elsevier espana rights reserved
previous research established media violence causal risk factor aggressive behavior several theoretical mechanisms identified explain effect present study assessed undergraduate students test possibility individual differences attention problems impulsiveness help explain link violent media aggression attention problems impulsiveness proved distinct construct processes believed mediate aggression aggressive beliefs aggression related schemata trait anger trait hostility attention problems impulsiveness uniquely related media exposure total weekly hours violent content aggression attention problems impulsiveness particularly related impulsive opposed premeditated aggression results suggest attention problems impulsiveness may play important role violent media effects aggression aggr behav wiley periodicals inc
paper presents series unconsolidated undrained triaxial compression tests investigating behavior failure mechanism geotextile reinforced clay effects sandwiching nonwoven geotextile thin layer sand sandwich technique improving shear strength reinforced clay test variables include confining pressures number geotextile layers thicknesses sand layers mobilized tensile strain reinforcements estimated according residual tensile strain using digital image processing technique used directly quantify effects soil geotextile interaction shear strength improvement test results showed shear strength reinforced clay increased number geotextile layers increased failure patterns changed classical rankine type failures unreinforced soil specimens bulging barrel shaped failures adjacent geotextile layers effectiveness reinforcing clay applying nonwoven geotextile attributed increase apparent cohesion reinforced clay specimen regarding sandwich technique test results revealed layers sand encapsulating reinforcement effectively provide improved soil geotextile interaction thereby enhancing shear behavior reinforced clay shear strength increased thickness sand layer increased optimal value sand layer thickness maximum shear strength improvement observed large confining pressures appreciable shear strength improvement still observed sand layer thickness increased sigma kpa sandwich technique contributes shear strength improvement increasing friction angle reinforced specimens mobilized tensile strain force geotextile increased number geotextile layers thicknesses sand layers confining pressure increased mobilized tensile strain force strongly correlated strength difference reinforced unreinforced soil experimental finding demonstrated mobilized tensile strain force directly contribute shear strength improvement reinforced clay american society civil engineers
background oral squamous cell carcinoma oscc minor subset cancer stem cells identified using surface marker cell population involved initiating maintaining expanding tumor growth reported involved angiogenesis date methods nod scid mice equipped dorsal skinfold chambers gelatin sponges seeded unsorted cancer cells suspended matrigel implanted following intravital fluorescence microscopy specimens examined immunohistology results sponges seeded cells showed significantly higher functional capillary density seeded cells presence endothelial cells confirmed immunohistochemistry conclusion first time tumorigenic cells angiogenic potential isolated oscc characterized findings provide promising vivo model facilitate development therapeutic agents cancer stem cells angiogenic pathways elsevier inc rights reserved
background computer delivered cognitive behavioural therapy ccbt effective alternative provider delivered treatment depression anxiety high attrition poses significant challenge use peer support feasible approach improving ccbt engagement less known acceptability among veterans aims obtain feedback veterans depression anxiety preferences activities veterans administration peer support specialists pss helping veterans use moving forward ccbt based protocol developed methods delivering support veterans using programme method four focus groups veterans per group provided feedback used development peer supported engagement intervention help veterans depression anxiety use moving forward content areas included roles pss might play supporting use engagement moving forward well methods delivering support results veteran preferences pss activity focused practical aspects using moving forward including orientation programme technical support monitoring progress feedback also suggested veterans preferred personal roles pss including emotional support well application moving forward real life problems conclusions findings extend literature online patient facing mental health protocols identifying emotional support real life skills application veteran preferred components peer support protocol designed enhance use engagement ccbt depression anxiety
paper present research design framed feminist epistemology research proposal study impacts male unemployment division household chores responsibilities suburb barcelona understanding complexity type research proposal created theoretical framework allows understand aspects take account undertake study involuntary male unemployment mean men take domestic caretaking responsibilities economic crisis change gender roles based dichotomy breadwinner caregiver design draws array previous studies demonstrate negotiations within home often exceed total amount income
background popularity transcriptomic analysis grown reported lack concordance different studies condition become growing concern raising questions representativeness different study types non human disease models studies surrogate tissues gene expression human condition methods comparison microarray studies parkinson disease correlation clustering analyses used determine factors influencing concordance studies including agreement different tissue types different microarray platforms neurotoxic genetic disease models human parkinson disease results concordance studies low correlation differential gene expression signatures average increases within human patients studies tissue type rising studies human substantia nigra agreement animal models however dependent model type studies brain tissue parkinson disease patients specifically substantia nigra form distinct group showing patterns differential gene expression noticeably different non brain tissues animal models parkinson disease comparison brain diseases alzheimer disease brain cancer suggests mixed study types display general signal neurodegenerative disease meta analysis microarray studies demonstrates greater ability studies humans highly affected tissues identify genes previously known associated parkinson disease conclusions observed clustering concordance results suggest existence characteristic signal parkinson disease found significantly affected human tissues humans results help account consistency lack thereof far observed microarray studies parkinson disease act guide selection transcriptomic studies representative underlying gene expression changes human disease
purpose purpose paper synthesize equivalent circuit obtained reduced order model large scale inductive peec circuits design methodology approach paper describes original approach reducing synthesizing large parasitic rlm electrical circuits coming inductive partial element equivalent circuit peec models proposed technique enables use reduced order model time domain circuit simulation context findings paper shows use synthesis method realize equivalent circuit issued compressed peec circuits originality value coupling methods peec compressed method fast multipole method order reduce time space consuming well known innovation realize smaller circuit equivalent original large scale peec circuits use temporal simulation tools moreover synthesis method reduces time memories modelling industrial application maintaining high accuracy
manipulator control important problem robotics work problem correct dynamic model robot manipulator must hand hence work first presents dynamic model existing dof robot manipulator based euler lagrange principle utilizing body jacobian link generalized inertia matrix furthermore essential properties dynamic model analyzed purpose control pid controller designed control position robot decoupling dynamic model achieve good performance differential evolution algorithm used selection parameters pid controller feedback linearization scheme also utilized position trajectory tracking control manipulator obtained results reveal pid control coupled differential evolution algorithm feedback linearization control enhance performance robotic manipulator also found increasing masses manipulator links affect performance pid position control higher control torques required cases
representation choice development search operators crucial aspects efficiency evolutionary algorithms eas combinatorial problems several researchers proposed representations operators eas manipulate spanning trees paper proposes new encoding called node depth phylogenetic based encoding npe npe represents spanning trees relation nodes depths using relatively simple codification decodification process proposed npe operators based methods used tree rearrangement phylogenetic tree reconstruction subtree prune regraft tree bisection reconstruction npe operators designed high locality feasibility low time complexity unbiased independent weight therefore npe good choice data structure eas applied network design problems elsevier rights reserved
nasa new horizons flyby mission pluto charon binary system four moons provided humanity first spacecraft based look large kuiper belt object beyond triton excluding system multiple kuiper belt objects kbos observed years earth kbo size distribution unconstrained except among largest objects small kbos remain beyond capabilities ground based observatories foreseeable future one best ways constrain small kbo population examine craters made pluto charon system first step understanding crater population map work describe steps undertaken produce robust crater database impact features pluto charon two largest moons nix hydra include examination different types images image processing present analysis variability among crater mapping team crater diameters found average uncertainty across sizes measured similar also present basic analyses crater databases finding pluto craters differential size frequency distribution across encounter hemisphere power law slope approximately diameters approximate charon slope diameters significantly shallower bodies smaller diameters also better quantify evidence resurfacing evidenced pluto craters contrast charon work also releasing database potential probable impact craters pluto charon nix hydra elsevier inc rights reserved
objective chronic periodontitis associated increased systemic inflammation osteoporosis proinflammatory cytokines implicated systemic bone loss also associated periodontitis impact control systemic inflammation scaling root planing srp bone mineral density bmd postmenopausal osteopenic women investigated study method materials sixty eight osteopenic women included test group received srp along calcium vitamin supplementation twice day months control group received calcium vitamin supplemen tation twice day months bmd serum high sensitivity reactive protein hscrp periodontal parameters recorded baseline months results improvement bmd serum hscrp showed statistically significant difference groups months binomial logistic regression analysis revealed test group adjusted times likely exhibit normal bmd months results suggest association control systemic inflammation srp improved bmd osteopenic women generalized severe
understanding receptivity including concerns drivers water users householders vital facilitating promotion appropriate installation end use maintenance rainwater harvesting rwh systems article presents triangulated results literature review survey undertaken increase policy makers understanding householder receptivity rwh identified overall receptivity rwh high factors pertaining particularly cost maintenance pose threats receptivity three areas improvement identified product development capacity building support services recommendations action provided present policy makers starting point enhance receptivity householders rwh
many types servers exists includes publicly accessible servers internal servers mail servers web servers application servers build test servers etc store many confidential sensitive information providing security servers become one core requirements today world risk attack data stored server range organizational information confidential customer related documents project details corporation software source code private media information personal data national security related information patients database question papers competitive exams etc sensitive data gets wrong hands misused thus business reputation organization would beat stake also pose threat nations main reasons security breach servers due use portable storage devices pen drives hard disks etc potential carriers malware trojans infected virus portable storage devices cause severe damage manually maintaining securing servers would difficult also lead huge administrative overhead hence need automated security mechanism detect prevent protect servers attackers security policies play important role preventing compromise network security would affect server security paper proposes framework would ease work administrator itfocuses designing automated tool would perform audit servers check compliant prescribed security policies multiple platforms upon servers run tool designed adapt heterogeneous environment
despite considerable interest understanding stress influences memory accuracy errors particularly children methodological limitations made difficult examine effects stress independent effects emotional valence remembered information developmental populations study manipulated stress levels year olds exposed negative neutral positive word lists shortly afterward tested recognition memory words false memory non presented related words adolescents high stress condition accurate low stress condition children accuracy differ across stress conditions also among adolescents accuracy errors higher negative positive words children word valence unrelated accuracy finally increases children adolescents cortisol responses especially high stress condition related greater accuracy false memories positive emotional words findings suggest stress encoding well emotional content remembered information may influence memory different ways across development highlighting need greater complexity existing models true false memory formation
mild eco friendly method developed synthesis series diaminopropan ols epoxide epichlorohydrin undergoes ring opening amines using mgso mixed metal oxides catalysts mild neutral conditions afford corresponding beta amino alcohols excellent yields preliminary evaluation relaxant activity carried rat tracheal rings contracted carbachol tested compounds exhibited significantly relaxant effects concentration dependent manner compound found active twofolds potent theophylline positive control compound potential development anti asthma drug
visual feature learning aims construct effective feature representation visual data wide range applications computer vision often posed problem nonnegative matrix factorization nmf constructs linear representation data although nmf typically parallelized efficiency traditional parallelization methods suffer either expensive computation high runtime memory usage alleviate problem propose parallel nmf method called alternating least square block decomposition alsd efficiently solves set conditionally independent optimization subproblems based highly parallelized fine grained grid based blockwise matrix decomposition assigning block optimization subproblem individual computing node alsd effectively implemented mapreduce based hadoop framework order cope dynamically varying visual data present incremental version alsd able incrementally update nmf solution low computational cost experimental results demonstrate efficiency scalability proposed methods well applications image clustering image retrieval
porous magnesium based materials biodegradable promising use orthopaedic applications applications hampered difficult fabrication work reports preparation porous magnesium materials powder metallurgy technique using ammonium bicarbonate spacer particles porosity materials depended amount ammonium bicarbonate found strong negative effects flexural strength corrosion behaviour however flexural strength materials porosities vol higher flexural strength non metallic biomaterials comparable natural bone elsevier rights reserved
main aim study understand adolescents express identities virtual worlds fifty nine south african high school learners females completed interview survey regarding online interactions important personal identities adolescents completed think aloud interviews verbalisations surveys focussed behaviour beliefs attitudes opinions feelings expectations self classification level involvement social media data thematically analysed profiled theme utilising frequency distributions results suggest adolescents try new identities including assumed idealised identities self report say things online ordinarily would offline social desirability reasons adolescents appear inhabit two reality worlds important enactment identities construct online friends strangers
field children adolescents media predominantly focused harmful media effects instance concerning potential harm media violence although recognize relevance research propose balance field restored research also considers beneficial effects media exposure essay introduce positive media psychology arena children adolescents media incorporating insights field positive psychology pioneering work meaningful media entertainment among adults provide theoretical backdrop future research examine media help children adolescents thrive flourish
work focus temporal spatial characteristics tgfbeta expression various human eye tissues prenatal development fetal weeks used complex approach analysis tgfbeta gene expression pcr localization tgfbeta protein immunohistochemistry tgfbeta detected eye tissues results suggest differential expression pattern tgfbeta lens retina correlated cell type differentiation state data obtained give evidence tgfbeta contribution forming eye tissues various embryonic origins
inherent broadcast capabilities satellites make attractive solution delivery multimedia services mobile users third generation networks reliable delivery content hostile land mobile satellite channel one key technical system requirements addressed different protocol layers paper focus attention mechanisms provide partial reliability packet level forward error correction plfec technique radio access network ran different interleaving depths physical layer inter frame power allocation satellite radio interface rely end end simulation platform order assess performance gain achieved mechanisms separately provide clear indications achievable benefits system level mechanisms act ordination rather isolation copyright john wiley sons ltd
pumping sediment laden water excavations often necessary construction sites water often treated pumping geotextile dewatering bags bags designed filter fine sediments create high turbidity dosing flocculant prior bag could result greater turbidity control study compared two systems introducing flocculant passive dosing commercial solid biopolymer chitosan injection dissolved polyacrylamide pam length corrugated pipe connected bag biopolymer system consisted sequential porous socks containing charging agent followed chitosan corrugated pipe two levels dosing dissolved pam injected turbid water flow weighted concentration treatment sediment laden turbid water range nephelometric turbidity units ntu pumped upstream corrugated pipe samples taken pipe entrance pipe exit dewatering bag exit without flocculant treatment dewatering bag reduced turbidity addition flocculant increased turbidity reduction relative influent pipe exit low dose biopolymer less effective reducing turbidity equally effective high dose biopolymer pam injection bag results suggest relatively simple treatment flocculants either passively actively effective reducing turbidity pumped water construction sites elsevier ltd rights reserved
present study explores implementation district heating cooling systems across broad set case studies reported literature topics addressed include history system identification energy sources design considerations environmental impact economic feasibility performance analysis role energy policy history district heating cooling systems reveals available technology influenced configuration district energy systems efficient cleaner methods providing heating cooling arisen leads system identification based primary energy sources including deployment renewable energy streams advantages disadvantages energy source examined detail policies created government international entities major impact future research development district energy systems incentives may become necessary creating favorable conditions efficient construction utilization district heating cooling outcomes policies influence design considerations underlying district energy system contribution sustainability studies greenhouse gas emissions along economic impacts district energy construction part design process optimization district energy systems include economic environmental considerations solely thermal efficiency district heating cooling systems often integrated components absorption chillers cogeneration thermal energy storage performance analysis using exergy energy analysis revealed several sources irreversibility district heating systems elements understood properly greatly enhance system operation awareness accommodation many factors discussed paper improve soundness district heating cooling installation published elsevier ltd
paper deals rare earth free permanent magnet traction machine design segment electric vehicle four different ferrite permanent magnet synchronous machine topologies different magnets arrangement pole pair number selected high potential presented compared thanks computationally efficient finite element based analysis tool developed purposely found flux focusing machine poles slots outperforms terms torque speed requirement fulfillment efficiency power weight ratio influence magnet grade resilience demagnetization symmetrical short circuit condition selected machine investigated shown machine subject complete demagnetization low grade hard ferrite ceramic adopted thereby fostering research new abundantly available magnet grades key penetration new cost effective electrical machines powertrain market
recent theoretical accounts proposed excitation inhibition imbalance possible mechanistic networklevel hypothesis underlying neural behavioral dysfunction across neurodevelopmental disorders particularly autism spectrum disorder asd schizophrenia scz two disorders share overlap clinical presentation well convergence underlying genes neurobiology however also clear points dissociation terms phenotypes putatively affected neural circuitry highlight emerging work clinical neuroscience literature examining neural correlates imbalance across children adults asd adults chronic early course scz discuss findings diverse neuroimaging studies across distinct modalities conducted electroencephalography magnetoencephalography proton magnetic resonance spectroscopy functional magnetic resonance imaging including effects observed task rest throughout review discuss points convergence divergence asd scz literature focus disruptions neural balance also consider findings relation predictions generated theoretical neuroscience particularly computational models predicting imbalance across disorders finally discuss human noninvasive neuroimaging benefit pharmacological challenge studies reveal mechanisms asd scz collectively attempt shed light shared divergent neuroimaging effects across disorders goal informing future research examining mechanisms underlying imbalance hypothesis across neurodevelopmental disorders posit translational efforts vital facilitate development neurobiologically informed treatment strategies across neuropsychiatric conditions
paper deals design real time implementation model predictive control mpc based reference governor industrial like microcontroller task governor provide optimal setpoints inner proportional summation difference psd controller mpc based governor synthesized line piecewise affine pwa function maps measurements onto optimal references achieve fast memory efficient implementation pwa function encoded binary search tree allows reference governor run sub millisecond scale even simple hardware proposed concept experimentally verified laboratory device involving magnetic levitation system psd controller responsible controlling vertical position ball magnetic field using reference governor control performance significantly improved input output constraints enforced systematic manner
background patient adherence important increasing use oral anticancer drugs recent studies reported different capecitabine adherence rates based self reporting microelectronic monitoring medication bottle patient awareness monitored may confound results prescription records provide larger objective dataset adherence investigation report use computer algorithm manual review prescription medical documentation determine rate capecitabine adherence methods two years capecitabine prescription records five ambulatory cancer centres reviewed prescription data extracted using custom java based software tool compare predicted actual dispensing date difference dates primary adherence measure altered treatment date incident estimated using computer algorithm manual review medical charts results refill prescriptions associated altered treatment date incident based initial computer algorithm reduced adjusting clinic scheduling processes manual chart review adjust valid reasons delay reasons altered treatment date incident identified prescriptions conclusions adherence rate capecitabine based refill data seem high consistent findings based patient self report population analysis prescription data custom computer algorithm may identify trends capecitabine adherence efficiency manual review would likely required verify results accuracy using altered prescription refill dates adherence measure requires studies
objective describe rate contraceptive use types contraception used low income women design descriptive study used survey women contraceptive use sexual behaviors months prior time interview participants setting convenience sample low income women living three urban medically underserved neighborhoods enrolled larger study included methods univariate bivariate descriptive analyses conducted using stata results forty eight women african american hispanic white women age years mean years forty percent women pregnant planning get pregnant sex without contraceptives past months percentage women used contraception decreased users last months current users common methods used within last months condom use male partner birth control pills contraceptive injection intrauterine device patch conclusions many low income women medically underserved neighborhoods use contraceptives used contraceptives majority used least effective methods
background purpose study define treatment response remission cut point scores beck depression inventory second edition bdi used monitor seasonal affective disorder sad treatment methods data two published randomized clinical trials sad utilized complete roc analysis define response remission thresholds bdi structured interview guide hamilton rating scale depression seasonal affective disorder version sigh sad used reference standard data two trials included bdi sigh sad scores patients baseline weeks post treatment year next winter results bdi score derived criterion remission sad bdi score decrease baseline criterion treatment response limitations study participants primarily female caucasian demographic diversity sample limited conclusion study validated bdi scores compared sigh sad reference standard bdi greater potential widespread use clinicians sigh sad monitor sad patients brief self report instrument conveniently administered waiting room elsevier rights reserved
increase survival rate shift age composition women menopause emerging one major health issues sociology health thanks demographic transition sizeable number women spend one third half life post menopausal present paper focuses upon prevailing discourses women menopausal health indian setting suggests though women health beliefs behaviour coping patterns indian context differ western counterparts huge similarities found sociocultural medical discourses menopause discourses women marginalised seen inferior men however epidemiological studies women menopausal health india suggest menopause normal life event menstruation ceases associated bio psycho social morbidity paradigm prevalent west
since development around psychiatry oscillating poles sciences humanities directed towards subjective experience one hand towards neural substrate hand today dualism seems overcome naturalism identifies subjective experience neural processes according griesinger frequently quoted statement mental diseases brain diseases progress achieved neurobiological paradigm level fundamental science contrast tendency isolate mental illnesses patients social relationships neglect subjectivity intersubjectivity explanation searched therefore overarching paradigm able establish psychiatry relational medicine encompassing sense science practice biological psychological social relationships disorders within paradigm brain may understood investigated central relational organ without reductionist constrictions
background data prevalence vitamin deficiency children non immunoglobulin ige mediated gastrointestinal food allergy aims study understand prevalence vitamin insufficiency deficiency children non ige mediated gastrointestinal food allergy identify predisposing factors methods retrospective study looked data great ormond street hospital january september children years old confirmed diagnosis non ige mediated gastrointestinal food allergy vitamin level measured course disease included low vitamin levels defined nmol insufficient levels defined nmol deficient levels nmol patient characteristics clinical factors also recorded results ninety two patients met study criteria female median age years months iqr years months years months cohort low vitamin levels insufficient vitamin levels vitamin deficiency gender age significantly associated low vitamin levels twelve percent children amino acid formula aaf low vitamin compared children clinical factors found significantly associated low vitamin levels conclusions children non ige mediated gastrointestinal food allergy risk vitamin insufficiency deficiency prospective studies need performed children non ige mediated gastrointestinal food allergies trial registration study registered gosh research development department retrospective case note review health research authority confirmed nhs research ethics committee approval required thus trial registration number
hirota bilinear transformation symbolic computation maple class lump solutions rationally localised directions space reduced generalised dimensional shallow water wave sww equation prensented resulting lump solutions contain six parameters two free due translation invariance sww equation four must satisfy nonzero determinant condition guaranteeing analyticity rational localisation solutions derived interaction solutions lump solutions one stripe soliton result shows particular lump solutions specific values involved parameters drowned swallowed stripe soliton furthermore extend method general combination positive quadratic function hyperbolic functions especially interesting rogue wave found aroused interaction lump solutions pair resonance stripe solitons choosing values parameters dynamic properties lump solutions interaction solutions lump solutions one stripe soliton interaction solutions lump solutions pair resonance solitons shown dynamic graphs
decentralized punishment maintain contributions public good high level positive effect holds even situations involving inequality punishment power meaning relative costs punishment differ persons extend line research examining additional influence instability thus potential competition punishment power public good experiments previous research inequality operationalized assigning role strong player one group member punish others reduced cost compared players instability operationalized fact role assignment change across rounds contingent behavior previous rounds three experiments show unequal unstable punishment power individuals behave competitively engage race power resulting detrimental effects group specifically find unstable power goes along disproportionate use punishment inequality rather combination instability inequality causes effect iii excessive use punishment found role strong player assigned individuals previously behaved rather selfishly also prosocial behavior leads top speaking generalizability findings implications organizational settings discussed copyright john wiley sons ltd
brain imaging plays important role study alzheimer disease atrophy found occur hippocampal formation early disease stages progress parallel disease evolution aim present study evaluate possible correlation small world characteristics brain connectivity architecture extracted eeg recordings hippocampal volume patients dataset subjects including mmse healthy nold mmse individuals evaluated weighted undirected networks built eloreta solutions cortical sources activities moving eeg recordings evaluation hippocampal volume carried subgroup patients received high resolution weighted sequence underwent processing surface based cortex reconstruction volumetric segmentation using freesurfer image analysis software results showed quantitatively correlation observed right hemisphere trend seen hemispheres alpha band connectivity negatively correlated slow delta fast frequency beta gamma bands positively correlated hippocampal volume namely larger hippocampal volume lower alpha higher delta beta gamma small world characteristics connectivity accordingly small world connectivity pattern could represent functional counterpart structural hippocampal atrophying related network disconnection
rationale idiopathic pulmonary fibrosis ipf progressive fatal lung disease suggested cells may contribute ipf pathogenesis studies focused primarily cells outside pulmonary interstitium thus role cells diseased lung tissue remains unclear objective identify whether specific cell subsets differentially represented lung tissue patients ipf methods cell subsets measured lung tissue obtained patients ipf time lung transplantation age gender matched organ donors known lung disease subsets identified surface expression ccr ccr cxcr chemokine receptors cell subsets correlated measurements lung function obtained prior transplantation results compared controls ipf patients higher proportion lung cells higher proportion ccr cells lower proportion ccr cells increase ccr cells ipf lung tissue due increased tregs intriguingly increase ratio ccr cells ccr cells correlated significantly better lung function conclusion findings suggest new paradigm cell infiltrates ipf lungs detrimental instead specialized subsets may actually protective thus augmentation chemokines recruit protective cells blocking chemokines recruit detrimental cells may constitute novel approach ipf therapy
deriving spatial distribution specific catchment area sca gridded digital elevation model dem one important issues digital terrain analysis conventional methods usually estimate sca cell using flow direction algorithm results obtained often unsatisfactory recently gallant hutchinson water resources research proposed differential equation quantifies change sca along slope line thus numerical solution sca point surface calculated accurately integrating differential equation however obtaining numerical sca solution based differential equation computationally intensive time consuming use derive overall sca spatial distribution gridded dem study developed parallel algorithm based openmp make numerical sca solution based gallant hutchinson differential equation practical derive spatial distribution sca gridded dem experiments based two artificial surfaces theoretical sca complex real terrain surface demonstrated proposed parallel algorithm obtained satisfactory acceleration performance much lower error mfd algorithm representative conventional grid based flow direction algorithms due speedup effects proposed parallel algorithm analyzed effects dem grid size integration step length numerical sca solution detailed experiments experimental results suggested proposed algorithm performed best normally resolution step ratio suitable applications proposed parallel algorithm
inconsistent findings role blastocystis infection irritable bowel syndrome ibs present study aimed determine frequency blastocystis subtypes patients ibs total patients ibs healthy individuals referred medical laboratory centers ahvaz southwest iran participated study frequency blastocystis determined blastocystis genomic dna extracted positive feces pcr performed using seven primer pairs targeting ssu rdna gene blastocystis detected patients ibs individuals without ibs difference two groups statistically significant among five subtypes blastocystis common patients ibs control group however significant differences two groups terms subtypes blastocystis seems role blastocystis etiology ibs investigated furthermore model study designed investigate role host factors severity parasitic disease published elsevier ireland ltd
using fly cutter machine potassium dihydrogen phosphate kdp crystals rippling machined surfaces remain significant impact optical performance analysis lowspatial frequency ripples presented influence root mean squared gradient grms wavefront discussed frequency analysis machined kdp crystal surfaces performed using wavelet transform power spectral density methods based classification time frequencies macroripples multimode vibration machine tool found main reason surface ripples produced improvements machine design parameters proposed limit effects wavefront performance kdp crystal society photo optical instrumentation engineers spie
paper general synthesis procedure using signal flow graph technique realize nth order allpole lowpass current transfer function current follower transconductance amplifiers cftas presented proposed circuit general contains cftas grounded capacitors without needing external passive resistors also shown design procedure given simple structure convenient tunability suitable integration furthermore circuit low sensitivity pspice simulation results agree well theoretical analysis also included
aim work introduce computer aided design cad tool enables design large skull defect implants functional aesthetically correct custom implants extremely important patients large cranial defects cases preoperative fabrication implants recommended avoid problems donor site morbidity sufficiency donor material quality finally crafting correct shape non trivial task increasingly complicated defect size present cad tool design implants neurocranium combination geometric morphometrics radial basis functions namely thin plate splines allows semiautomatic implant generation method uses symmetry best fitting shape estimate missing data directly within radiologic volume data addition approach delivers correct implant fitting via boundary fitting approach method generates smooth implant surface free sharp edges follows main contours boundary enabling accurate implant placement defect site intraoperatively present approach evaluated compared existing methods mean error missing landmarks error less equal obtained conclusion results show cad tool generate patient specific implants high accuracy
emerging use self avatars physical motor rehabilitation leads specific requirements real time animation combine properties fields computer graphics biomechanics present method animating self avatar real time allows high fidelity representation whole body kinematics using anatomical reproducible bone segment definition method requires little setup time low motion photon latency
prandtl ishlinskii hysteresis models used widely magnetic smart material based systems generalized model consisting weighted superposition generalized play operators capable characterizing saturated asymmetric hysteresis fidelity model hinges accurate representation envelope functions play operator radii corresponding weights existing work typically adopted predefined play radii performance could far optimal paper novel schemes proposed optimally compressing generalized models subject complexity constraint characterized number play operators information theoretic tool entropy adopted capture information loss replacing group weighted play operators single play operator optimal compression algorithm reformulated optimal control problem solved dynamic programming computational complexity shown much lower exhaustive search simulation results first presented examine performance proposed approach approximating model consisting large number play operators cases different types weight distributions explored approach applied compress experimentally identified generalized model complex hysteresis behavior resistance temperature vanadium dioxide promising multifunctional material simulation experimental results demonstrate proposed algorithms general yield far superior performance typically adopted scheme play radii assigned uniformly elsevier ltd rights reserved
objective residential patients diagnosed borderline personality disorder evaluated determine whether borderline personality disorder focused psychotherapy reduced prescribing personality disorder morbid symptom severity method psychotropic prescriptions measured admission discharge year later female participants one personality disorder diagnosis morbid mood disorders changes pharmacotherapy examined context improvements borderline personality disorder morbid disorder symptom severity residential treatment included individual group psychotherapy borderline personality disorder structured clinical interview dsm used confirm borderline personality disorder diagnosis associated morbid conditions beck depression inventory completed time point results significant reduction incidence severity self rated depression well clinician assessed personality disorder including borderline personality disorder accompanied reduction prescription psychoactive medications conclusions three six months intensive borderline personality disorder specific psychotherapy showed lasting benefit regard symptom severity personality disorders borderline personality disorder particular well depressive symptoms improvement corresponded reduction prescriptions psychoactive medications consistent current thinking regarding treatment borderline personality disorder
purpose article aims evaluation prototypal assistive technology alzheimer disease patients helps remember personal details familiar people meet daily lives method architecture proposed personal information system powered face recognition main patient interaction performed smart watch device face recognition carried cloud prototype developed perform tests real life scenario results prototype showed correct results personal information system based face recognition however usability flaws identified interaction smart watch conclusions architecture showed correct performance realized could introduced fields apart assistive technology however targeted patients dementia usability problems appeared difficulties read information small screen take proper photo problems addressed research
reliable scalable ambient intelligence means distributed system agents capable working together autonomously depending requirements situation previous research argued favor use representation context information distributed among agents agent knows information relevant activity recognizing interesting information relevant situations done using context patterns graph patterns potentially unknown nodes edges labeled regular expressions context major challenge agents use graph matching algorithm adequate possibilities devices agents running moreover necessary algorithm able provide partial matches paper presents algorithm specifically designed problem uses growing partial matches obtain maximum sub graph context graph matches part context pattern experiments performed algorithm performance compared algorithms adapted problem
relational database data stored primary secondary tables propositionalization transform relational database single attribute value table hence becomes useful technique mining relational databases however existing propositionalization approaches deal categorical attributes handle threshold attribute threshold number objects satisfying condition attribute time paper propose new propositionalization technique called cardinalization solve problems order handle relative numbers propose second variant approach called quantiles discretize cardinality cardinalization achieve fixed number features therefore quantiles method tuned different deployment contexts additionally often observe best combination propositionalization classification methods depends new context online incremental learning one effective solution could predict optimal combination training time use different deployment contexts also propose effective wrapping algorithm called wpc wrapper combine propositionalizer classifier select best combination propositionalization classification methods address task extensive performance analyses synthetic real life datasets show approach effective efficient relational data mining elsevier ltd rights reserved
higher plasma cholesterol levels associated lower parkinson disease risk apolipoprotein apoa surface marker brain hdl like particles associated time onset clinical correlates serum apolipoprotein levels structural brain connectivity related disorders remains unclear applied novel diffusion weighted imaging approach diffusion magnetic resonance imaging mri connectometry explore association apoa structural brain connectivity participants involved research recruited parkinson progression markers initiative ppmi diffusion mri connectometry conducted using multiple regression apoa patients dti measurements available baseline visit fiber results connectometry reconstructed patient diffusion parameters extracted regressed apoa levels connectometry results revealed subgenual cingulum associated apoa different fdr yields result supported significant negative correlation quantitative anisotropic left subgenual cingulum pearson coefficient generalized fractional anisotropic gfa right subgenual cingulum pearson coefficient plasma apoa levels multiple regression model age sex subgenual cingulum encompasses fibers anterior cingulate cortex anterior thalamus structures involved associated psychosis executive cognitive decline demonstrated first time apoa blood marker predict microstructural changes white matter regions patients undisturbed cognition mild motor disability
study explored salience ethnic public private collective self esteem among south african students contrasting race participants black white undergraduate students females males mean age years completed two subscales collective self esteem scale measuring ethnic private public collective self esteem logistic regression bootstrapping tests applied examine differences public private collective self esteem within race findings suggest white students report higher public collective self esteem lower private collective self esteem compared black students expression collective self esteem may tied private rather public images among black south african students exposure intergenerational marginalization consequent apartheid legacy
introduction vaccination salmonella typhi one leading public health interventions reducing risk typhoid fever two available licensed vaccines vivotif oral live attenuated typhim intramuscular capsular polysaccharide military high risk travel population commonly vaccinated typhi describe use typhi vaccination population acute reactogenicity profile vaccines methods data obtained defense medical surveillance system vaccination identified vaccination codes clinical outcomes assessed four weeks post vaccination adverse event rates odds ratios estimated across two vaccine types results total million predominately male military personnel received million typhi vaccinations vaccinees receiving capsule vaccine though variability vaccine administered observed receipt vaccinations months surrounding typhi vaccine common rates nausea per vaccinations headache per vaccinations fever per vaccinations significantly higher following capsule vaccination compared receipt vivotif per vaccinations respectively contrast rates rash non infectious diarrhea per vaccinations respectively increased receiving vivotif compared capsule vaccine discussion military major consumer typhi vaccines parenterally administered vaccine appears amenable though limited ability assess reasons higher usage observed higher rate several adverse events subjects receiving intramuscular vaccination overall rate events low future studies assessing long term health outcomes warranted published elsevier ltd
work presents characteristic mechatronic system describes relation displacement free end beam voltage supplied piezoelectric transducer bonded beam surface considered system described discrete continuous mathematical model approximate galerkin method used analyse work presents analysis flexural vibrating one dimension machatronic system cantilever beam piezoelectric actuator glued onto surface beam taking account eccentric tension glue layer considered system modelled combined beam made beam glue layer piezoelectric transducer substitute cross section considered mechatronic system introduced unify material parameters area moment inertia substitute cross section calculated using basic laws dependences theory strength materials stress substitute cross section surfaces assigned work connected previous authors works concerned analysis mechatronic systems piezoelectric dampers vibrations piezoelectric actuators done improve mathematical model considered system
volumes rainwater harvested site estimated short term storage capacity two methods graphical method analytical method first method considers difference demand supply specified period time second uses random events determine analytically storage capacity required guarantee draft comparison two methods indicates minor differences based volume water harvested applying methods run coefficient impervious surface arid semi arid area estimated new analytical approach long term storage capacity utilized estimate detention pond capacity site local natural streams apply method necessary estimate overall mean storage capacity soil conservation service method utilized technique confirmed graphical method
background people chronic kidney disease ckd must self manage illness assist slowing disease progression complex task requiring support healthcare professionals despite established importance person centred care people ckd rarely consulted regarding desires self management support sms methods cross sectional survey conducted face face queensland primary care clinic distributed australia wide via online interface promoted kidney health australia participants years old self reported doctor diagnosis ckd stage survey based upon existent literature identified areas ckd believe require additional support descriptive data generated mann whitney tests performed compare desires different groups participants results participants completed hardcopy survey clinic completed online version half female age ranged time since diagnosis ranged diagnosed years mdn years strong interest receiving additional support across areas reported mdns keeping positive attitude taking care mental physical health receiving highest rating younger highly educated working diagnosed longer ago women expressed stronger overall desire additional support conclusions addition information ckd medications everyday strategies ought prioritised patient education varying levels engagement eagerness learn self management highlight need person centred approach sms
background optimal antifungal agent empiric treatment invasive fungal diseases ifds febrile neutropenia controversial objective evaluate relative efficacy antifungals cause mortality fungal infection related mortality treatment response population methods pubmed embase cochrane library searched identify randomized controlled trials rcts two reviewers performed quality assessment extracted data independently pairwise meta analysis network meta analysis conducted compare antifungals results seventeen rcts involving patients included risk bias included studies moderate pairwise meta analysis indicated treatment response rate itraconazole significantly better conventional amphotericin network meta analysis showed amphotericin lipid complex conventional amphotericin liposomal amphotericin itraconazole voriconazole significantly lower rate fungal infection related mortality antifungal treatment differences outcomes among antifungals statistically significant rank probability plot caspofungin appeared effective agent cause mortality fungal infection related mortality whereas micafungin tended superior treatment response results stable excluding rcts high risk bias whereas micafungin lowest fungal infection related mortality conclusions results highlighted necessity empiric antifungal treatment indicates echinocandins appeared effective agents empiric treatment febrile neutropenic patients based mortality treatment response however studies needed determine best antifungal agent empiric treatment systematic review prospectively registered prospero registration number crd
fuel economy parallel hybrid electric vehicle hev suffers due significant energy losses wet clutches automatic transmission limited engine operations overcome limitations novel clutchless multimode parallel hev cmp hev proposed previously operational feasibility proven study propose systematic methodology assess feasibility cmp hev efficiently optimize acceleration performance design simultaneously using dynamic models assess feasibility entire design spaces two conditions full acceleration drivability moderate acceleration fuel efficiency instantaneous optimization method used rapidly evaluate full acceleration performance designs poor acceleration considered infeasible fuel efficiency feasibility determined violation electric motor constraints assumption efficient engine operations feasible design sets assessment used design optimization dynamic programming applied feasible design space pareto front obtained show tradeoff acceleration performance selected final design found superior comparable parallel hev acceleration performance perspectives
rumination involves excessive dwelling negative aspects problems within dyadic relationship rose research focused tendency ruminate within particular relationships interested examining behavior rumination outside context preexisting relationship using experimental manipulation rumination primary goal study experimentally test effects rumination examine associations negative positive affectivity participants randomly assigned one three interviewing style conditions ruminative style problem solving style distracting style results revealed rumination condition significantly differed distraction problem solving conditions overall negative affect sadness anxiety hostility significant differences among groups positive affect conclusion investigation revealed detrimental effects ruminative behavior even strangers
objective aim study investigate differences presence head neck shoulder trigger points trps women episodic chronic migraine association migraine related disability materials methods one hundred forty three women aged years migraine recruited participate study migraine related disability evaluated migraine disability assessment questionnaire trps explored bilaterally within masseter temporalis suboccipital sternocleidomastoid upper trapezius splenius capitis muscles results ninety eight women exhibited episodic migraine whereas chronic migraine women chronic migraine reported higher related disability episodic migraine women episodic migraine similar number trps total number active trps latent trps chronic migraine total number active trps latent trps linear association observed number trps migraine related disability women episodic chronic migraine conclusions women episodic chronic migraine similar number trps trps may considered trigger factor facilitate onset migraine also potentially promoting factor pain migraine attack started hence may contribute related disability nevertheless observed number trps head neck shoulder muscles interictal state associated degree migraine related disability suggesting multifactorial nature self perceived disability population
paper presents novel method modal system identification large mechanical structure combining results simulations physical measurements specifically reconstruction mode shapes accomplished comparing simulated measured amplitude ratios generated using nyquist analysis methodology developed paper improves upon traditional techniques allowing statistically cross referencing relatively sensor measurements relatively simple simulation model methodology used identify three major modal frequencies mode shapes main aluminum honeycomb sandwich panel gondola structure balloon borne imaging testbed bit bit stratospheric ballooning project astronomy launched september timmins ontario canada ensuring structural vibrations adversely affect pointing accuracy board telescope crucial success project paper also highlights advantages drawbacks presented methodology suggests improvements future applications balloon borne experiments american society civil engineers
background medication discontinuation remains big hurdle retaining persons schizophrenia treatment ambit imperative understand reasons effectively tackle methods study carried turuvekere rural south indian taluk administrative block qualitative interviews conducted consenting consecutive nineteen patients along family members discontinued medications interviews transcribed enlisted reasons color coded synthesize different factors patient onward new reason emerged three interviews done ensure additional reason results following factors average factors per patient led medication discontinuation lack support supervision family well wishers lack insight cooperation patient lack awareness illness adverse effects medications financial factors distance transport lack knowledge treatment process perceived lack beneficial effects treatment treatment center related issues others conclusions medication discontinuation driven diverse set interrelated factors among community living persons schizophrenia professionals need aware complexity effectively manage problem
overall objective project design device collect multiple aerosol samples various altitudes atmosphere device would aid biological investigation unexplained microorganisms travel vast distances across world extensive work done collaboration arkansas state university biology department develop criteria device needed meet device needed sample air sea level outer levels earth atmosphere determined feasible way travel distance would attaching device payload helium weather balloon next various intake sampling methods explored aim collect least samples varying uniformly altitude beginning approximately feet sample would collected every feet maximum altitude reached centrifugal pump chosen intake method allergenco impactor type adhesive slide particle capturing container chosen sampling prevent contamination solenoid valves used side impactor ensure sealing sample taken independent design testing electrical components functionality sensitivity carried using microcontroller ensure control valves sampling desired altitudes well monitoring various parameters use vacuum chamber sampling system tested required flow rates
patients preexisting active autoimmune disorders excluded clinical trials immune checkpoint inhibitors however patients autoimmune disorders diagnosed cancer least frequently global population clinicians treating patients outside clinical trials generally reluctant offer cancer immunotherapy patient group brief article review recent literature efficacy safety ctla blocking antibodies patients preexisting autoimmune disorders
background growth hormone major regulator growth body composition pulsatile secretion declines exponentially age testosterone replacement increasingly offered older men age related low testosterone testosterone administration shown stimulate secretion however little known effect testosterone aromatization estradiol pulsatility impact igf older men objective randomized controlled proof concept trial investigated relative effects testosterone estradiol pulsatility igf older men low testosterone design thirty seven men years total testosterone randomized transdermal testosterone gel oral aromatase inhibitor placebo daily months primary outcome deconvolution approximate entropy analyses pulsatile including basal entropic modes secretion performed baseline months secondary outcomes included igf evaluated baseline months results months mean igf similar three groups months igf significantly increased delta group compared placebo intervention groups significantly increased pulse frequency group group compared placebo secretory burst mode duration significantly decreased group compared placebo remained unchanged group conclusions older men testosterone increases pulse frequency aromatization estradiol involved rise igf levels elsevier inc rights reserved
single episodes cortical spreading depression csd believed cause typical migraine aura whereas clusters spreading depolarizations observed cerebral ischemia subarachnoid hemorrhage recently demonstrated release high mobility group box hmgbi cortical neurons csd rodent model dependent number csd episodes multiple csd episodes induce significant hmgbi release report multiple csd inductions caused microglial hypertrophy activation accompanied greater impact transcription activity hmgbi receptor genes tlr tlr total number cortical microglia affected hmgbi neurtalizing antibody hmgbi inhibitor glycyrrhizin abrogated multiple csd induced microglial hypertrophy moreover multiple csd inductions failed induce microglial hypertrophy tlr double knockout mice results strongly implicate hmgbi tlr axis activation microglia following multiple csd inductions increased expression lysosomal acid hydrolase cathepsin detected activated microglia immunostaining suggesting lysosomal phagocytic activity may enhanced multiple csd activated microglia
objectives aim study evaluate outcome treatment related morbidity pediatric patients nasopharyngeal carcinoma npc treated chemoradiotherapy methods retrospective review pediatric patients diagnosed npc majority patients treated neoadjuvant chemotherapy followed concurrent chemoradiation dose fractions eight patients treated intensity modulated radiation therapy remaining three dimensional conformal radiation therapy two dimensional simulation technique results median age patients years range years patients locoregionally advanced disease stage iii iva ivb histology cases undifferentiated carcinoma immunohistochemistry epstein barr virus latent membrane protein positive nine tested cases median follow surviving patients months range months respectively year overall survival event free survival efs rates estimated confidence interval respectively distant metastases predominant pattern failure treatment response showed independent association classification significantly associated efs xerostomia hypothyroidism dental caries neck fibrosis trismus dysphagia common late effects survivors radiation myelitis observed one patient conclusions treatment neoadjuvant chemotherapy followed concurrent chemoradiation provides good survival outcomes pediatric npc quality life survivors pertinent area necessitates consideration
background aim study investigate occurrence urinary schistosomiasis school children rural village northern senegal evaluate impact parasitic infection children health growth nutritional status methods cross sectional survey carried children resident village kassak nord senegal area highly endemic schistosoma haematobium data health nutritional status urinary schistosomiasis collected results overall prevalence urinary schistosomiasis school children kassak malnutrition children malnourished bmi age score baz significant linear growth retardation height age score haz children urinary schistosomiasis showed lower mean baz haz uninfected children haz positives haz negatives baz positives baz negatives also found infected children greater risk malnutrition baz conclusions results study support hypothesis urinary schistosomiasis affects negatively childhood health nutritional status importance planning intervention aimed monitoring control urinary schistosomiasis malnutrition
second green revolution needed double global food production next years requires use best technologies precision agriculture maximize production minimum input costs resources document shows advances development prototype direct acquired sensing information management fertilizes water applications precision agriculture present numerical computational stage prototype equipped laser sensors determine content water fertilizer nutrient row crops determining information key order know crop needs mentioned substance application devoted micro crops need swept high precision result size agricultural problem translates control engineering tracking problem
recent phylogenomic analysis suggested three strains isolated different copper mine tailings around world taxonomically affiliated sulfobacillus thermosulfidooxidans present detailed investigation genomic features particularly respect metabolic potentials stress tolerance mechanisms comprehensive analysis sulfobacillus genomes identified core set essential genes specialized biological functions survival acidophiles habitats despite differences metabolic pathways sulfobacillus strains also showed evidence stress management thereby enabling efficiently respond harsh environments analysis metabolic profiles provided novel insights presence genomic streamlining highlighting importance gene loss main mechanism potentially contributes cellular economization another important evolutionary force especially larger genomes gene acquisition via horizontal gene transfer hgt might play crucial role recruitment novel functionalities also successful integration genes acquired archaeal donors appears effective way enhancing adaptive capacity cope environmental changes taken together findings study significantly expand spectrum hgt genome reduction shaping evolutionary history sulfobacillus strains importance horizontal gene transfer hgt gene loss recognized major driving forces contribute adaptive evolution microbial genomes although relative importance remains elusive findings study suggest highly frequent gene turnovers within microorganisms via hgt necessary incur additional novel functionalities increase capacity acidophiles adapt changing environments evidence also reveals fascinating phenomenon potential cross kingdom hgt furthermore genome streamlining may critical force driving evolution microbial genomes taken together study provides insights importance hgt gene loss evolution diversification bacterial genomes
caffeine widely used psychostimulant western countries antioxidant anti inflammatory anti apoptotic properties alzheimer disease caffeine beneficial men women humans animals similar effects caffeine observed men parkinson disease however effect caffeine female patients controversial due caffeine competition estrogen estrogen metabolizing enzyme cypa studies conducted animal models amyotrophic lateral sclerosis als showed protective effects antagonism study found caffeine associated earlier age onset huntington disease intakes studies animal models found equivocal results caffeine protective dosages equivalent however research needed investigate effects caffeine women well effects caffeine als machado joseph disease need investigated caffeine salient mechanisms action relevant neurodegenerative diseases need explored
background smoking behavior smoking cessation complex interpersonal factors childhood adversity associated smoking especially women identifying individual factors contribute smoking behavior may support individualized smoking cessation strategies attachment insecurity attachment avoidance attachment anxiety involves biological psychological processes close relationships associated childhood adversity select populations smoking study aims identify association attachment insecurity smoking adults determine attachment insecurity plausible mediator childhood adversity smoking methods cross sectional survey primary care patients reported childhood adversity attachment insecurity smoking status statistical analyses performed using regression prodclin results sixty one percent participants experienced childhood adversity current smokers women attachment anxiety associated childhood adversity current smoking prodclin test indicated attachment anxiety may mediator childhood adversity current smoking women men current smoking associated childhood adversity attachment anxiety attachment avoidance related current smoking men women conclusions women men attachment anxiety associated current smoking may mediate relationship childhood adversity current smoking childhood adversity attachment anxiety may factors consider design cessation strategies women
present broadband polarization insensitive terahertz metamaterial absorber formed double layered sized patterned square patches top metallic ground plane combination two sized metallic patches gives rise absorption bandwidth ghz absorption full width half maximum device respect central resonance frequency double single layered structure mechanism broadband absorber attributed longitudinal coupling layers hybridized charge distribution model proposed analyzing origin resonance bandwidth proposed absorber potential applications detection imaging stealth technology
paper describes importance performing magnetic field analysis taking account model magnetic hysteresis order evaluate magnetic phenomena electrical motor obtained coil numerical analyses patterns performed using initial property hysteresis property model result hysteresis analysis indicate tendency obtained experiment using coil properly
application large sets experimental data containing measurement errors computational analyses without preprocessing lead distortion results therefore transformation data point wise given values smooth curves one key factors allowing proper utilization paper determination moisture diffusivity autoclaved aerated concrete function moisture content using measured moisture profiles processed smoothing presented processing experimentally measured data smoothing splines used
open architecture provides sustainable product framework mass personalised production applying personalised modules common interfaces open architecture product satisfy changes user requirements application planning product modules open architecture product structure using existing method challenging quality function deployment extended study decide open architecture product module types customer requirements divided two parts basic function needs changes individual customer needs based axiomatic design functional requirements mapped design parameters establish design matrix degree variety proposed quantitative measure component variability product modules according relationship components degree variety product components clustered open architecture product modules proposed method used design paper bag folding machine satisfy requirement changes machine application
purpose study explore psychometric properties chinese version autism spectrum rating scale asrs recruited community based children autism spectrum disorder asd cases sites parents participants completed chinese version asrs robust weighted least squares means variance adjusted estimator used exploratory factor analysis factor structure included items suitable current sample item reliability modified chinese version asrs asrs excellent moreover cut point receiver operating characteristic analysis showed asrs excellent discriminate validity comparable unmodified chinese version asrs area curve values respectively meanwhile confirm factor analysis revealed asrs better construct validity asrs based factor solution another children sample conclusion asrs shows better efficacy epidemiological screening asd chinese children
article presents new strategy based multistage fuzzy pid controller damping power system stabilizer multimachine environment using honey bee mating optimization hbmo proposed technique new metaheuristic algorithm inspired mating procedure honey bee actually mentioned algorithm used recently power systems demonstrate good reflex algorithm also finding parameters pid controller power system direct effect damping oscillation hence reduce design effort find better fuzzy system control parameters proposed controller obtained hbmo leads design controller simple structure easy implement effectiveness proposed technique applied single machine connected infinite bus ieee bus power system proposed technique compared techniques integral time multiplied absolute value error figure demerit wiley periodicals inc complexity
objective describe behaviors knowledge related sexual reproductive health spanish university students association subject area studied biomedical methods descriptive cross sectional observational study conducted students aged years university complutense madrid faculties medicine law simple random stratified sampling without replacement performed self administered anonymous voluntary questionnaire distributed based youth risk health behavior survey assessed behavior knowledge three areas sex contraceptive methods sexually transmitted infections stis results total respondents sexual intercourse mean age years mean sexual partners compared law students fewer medical students sexually active later age sexual initiation fewer sexual partners high regular use contraceptive methods observed significant differences groups although unprotected sex often used emergency contraception total respondents knew vaccine human papillomavirus relationship cancer vaccinated rates significantly higher conclusions behavior knowledge medical students relation sexual reproductive health differed law students elsevier rights reserved
previous studies racial ethnic variation urinary incontinence suggest population specific studies risk factors needed develop appropriate public health recommendations assessed risk factors among postmenopausal mexican women enrolled mexican teachers cohort conducted cross sectional study among postmenopausal women completed questionnaire cases women reported experiencing menopause self reported potential risk factors included age reproductive variables smoking status adiposity several health conditions estimated multivariate adjusted odds ratios ors confidence intervals cis using multivariable logistic regression among postmenopausal women prevalence odds higher among women children nulliparous women body mass index bmi age first birth years past current never smoking larger waist hip ratio history asthma high blood pressure diabetes also associated higher odds found trend lower odds older age data suggest information prevention strategies might particularly useful mexican postmenopausal women children higher bmi studies longitudinal data addition data severity subtype needed provide specific information risk factors mexican women
background inflammatory bowel disease develop context rheumatic diseases childhood including juvenile idiopathic arthritis jia inflammatory bowel disease ibd frequently associated immune mediated diseases however systemic onset jia sjia previously connected ibd treatment sjia significantly changed recent years possibly causing changes inflammatory patterns therefore data german center pediatric adolescent rheumtology analyzed retrospective chart review findings eighty two patients confirmed diagosis sjia found three identified diagnosis ibd confirmed colonoscopy two cases crohn disease one case ulcerative colitis years diagnosis three treated antagonists anakinra two cases canakinumab one case well controlled sjia symptoms time diagnosis ibd conclusions ibd seems rare possible complication sjia treatment antagonists might relevant factor switch clinical phenotype underlying inflammatory process
aim study assess measurement invariance commonly used measures youth psychopathic characteristics across sex racial ethnic groups among community sample hispanic black adolescents female mean age parents study tested configural metric invariance levenson self report psychopathy scale lsrp levenson fitzpatrick kiehl parent report version inventory callous unemotional traits frick preliminary analyses indicated adolescents present study reported similar rates psychopathic characteristics reported studies adolescents young adults results multigroup invariance analyses indicated measures invariant across sex hispanic black youth addition analyses assessing associations measures number behavioral emotional characteristics indicated scores lsrp scale callous unemotional traits demonstrate good convergent discriminant validity differences sex race ethnicity date research psychopathy focused predominantly samples white males therefore important research examines equivalence measures psychopathic characteristics across different populations accurate assessments made inform intervention treatment efforts
background micrornas mirnas reported involved cancer radio resistance remains major obstacle effective cancer therapy methods differently expressed mirnas detected rna seq experiment nasopharyngeal cancer npc cells mir selected target subject finding target gene rabb via bioinformatics analysis qrt pcr western blot luciferase reporter assays performed confirm rabb target mir addition roles mir npc radio resistance detected transfection either mir mimic mir antagomir involvement rabb npc radio resistance also detected experiments sirna mediated repression rabb expression gfp rabb wound healing invasion assays performed detect roles mir rabb results mir promotes npc radio resistance identified target gene rabb negatively correlates mir mediated npc radio resistance systematic studies radio sensitive cne resistant cne npc cell lines repression rabb sirna suppresses cell apoptosis passivates cne cells whereas overexpression rabb triggered cell apoptosis sensitizes cne cells conclusions mir target gene rabb might involved npc radio resistance thus key players regulators involved pathway might potential targets developing effective therapeutic strategies npc
substantial gap remains know type diabetes prevention ability apply knowledge socially disadvantaged populations highest risk gap results part lack integration epidemiologic science social psychology theory particularly regarding intersections stress self regulatory health behaviors biological mechanisms underlying development diabetes commentary describe utility theoretical framework focuses intersection biological psychosocial environmental contexts apply diabetes disparities framework could inform translational research agenda reorient prevention efforts address inequalities reorientation needed ensure implementation prevention efforts inadvertently widen diabetes disparities
hydraulic structure undermining attributable scour cause structural damage collapse experiments performed laboratory channel scour downstream stilling basin low head spillway ascertain feasibility air injection scour reduction idea previously attempted various hydraulic flow conditions without air injection indicate condition stilling basin water elevation lower spillway crest high headwater tailwater depth ratio results deepest scour experiments performed determine optimal parameters scour reduction air injection found optimal scour reducing conditions consist air injection air water velocity ratio vertical air injection elevation stilling basin exit point using diffuser hole diameters corresponding ratio air water velocity equal spanning entire width stilling basin diffuser hole spacing times diffuser width scour thus reduced approximately near structure air compressors diffuser pipe diameter hole sizes corresponding conditions would required prototype installations american society civil engineers
computer programming challenging skill students computer science related disciplines expected learn computer science educators students concerned failures programming competency programming errors reflect various details student conceptual understanding programming skills developed paper attempts predict failures programming comprehension debugging skills based programming errors generated learner conduct mixed method approach prepost test experimental design evaluate java programming competency learner also compute error metrics supplement course material improve competency self learning spoken tutorial workshops characterization student programming patterns helps identify risk students determine specific interventions analyze compilation errors computational time computed error quotients predict programming behaviour results study show students improved programming skills benefited approach implications study also helpful computing education practitioners workshop organizers content developers reviewers improvise course content
analysis process visual images gesture words paper realizes recognition gesture words lay good foundation recognize gesture language firstly acquired images preprocessed denoising secondly gesture images segmented background images setting thresholds outline gesture images information obtained morphology operations thirdly extracting centroid coordinates target gestures gesture images positioned segmented end gesture words identified calculating extreme values modules algorithm validated matlab software experimental results show algorithm reliable good robustness
order improve feedback stability flatness control system acceleration deceleration rolling process structure corresponding optimization model flatness control system established based flatness efficiency factors analysis work roll bending control loop flatness control system carried based analysis cause time delay corresponding influences system stability investigated moreover simulations implemented conventional pid controller smith predictor pid controller work roll bending control different time delays based investigation simulations new flatness control strategy including time delay compensation developed time delay varies flatness control system automatically switch control mode ensure system stability affected applications show proposed control strategy guarantee good stability high steady state precision flatness control system acceleration deceleration rolling process
paper focuses relationship remotely sensed urban site characteristics uscs land surface temperature lst particular emphasis put extensive comparison two dimensional three dimensional uscs potential indicators surface urban heat island uhi effect potential predictors thermal sharpening applications widely used well recently proposed metrics urban remote sensing literature investigated within single experiment uscs already used earlier others never analyzed context urban temperature studies addition comparison usc spatio temporal dependencies relation lst examined end experimental setup work includes two study areas usc lst scenes covering four seasons use made comprehensive database compiled cities berlin cologne germany data preparation high resolution vhr multi spectral height data employed map fine scale urban land cover resulting maps used conjunction height information compute uscs subsequently multi temporal lst images retrieved landsat enhanced thematic mapper plus etm scenes spatio temporal investigation usc lst connection constitutes final stage workflow achieved framework dedicated correlation analysis results study highlight linkage uscs lst sensed small scan angles stronger parameters considered even though may offer holistic representations urban landscape uscs consistently outperformed widely used metrics analysis spatial dependencies reveals usc lst interplay differ also within two test sites due distinct geographies urban form compactness green spaces street trees structural composition elements determining factors examination temporal dependencies yielded association uscs lst fairly stable time subject larger inter intra season variations different reasons including season acquisition vegetation phonology meteorological conditions since previous research based analysis single study area limited number mainly uscs lst scenes acquired specific seasons concluded findings study provide researchers practitioners complete picture usc lst relationship elsevier inc rights reserved
aims study aimed assess budgetary impact reimbursing varenicline patients chronic obstructive pulmonary disease copd type diabetes mellitus tdm cardiovascular diseases cvd methods estimated comparing current non reimbursed scenario versus projected reimbursed scenario using spanish national health system snhs perspective hybrid model developed using epidemiological data markov chains estimate smoking cessation rates varenicline year horizon costs cessation considered reimbursement scenario efficacy expressed year continuous abstinence rate derived clinical trials cost savings due smoking cessation extracted local cost illness studies results shown incremental cost savings univariate sensitivity analysis also applied results total patients stopped smoking reimbursed scenario compared without reimbursement reimbursed scenario total savings accounted sic million showing million accumulated additional savings compared scenario without reimbursement sensitivity analyses showed results robust monetary savings starting third year modeling conclusion reimbursement varenicline smoking cessation cost effective health policy snhs copd cvd could produce cost savings starting third year implementation karger basel
improve flexibility microbial desalination cell mdc construction operation new configuration decoupled anode cathode developed examined study higher salt concentration resulted higher current generation well higher salt removal rate effect distance anode cathode mdc performance obvious likely due sufficient conductivity salt solution cathode identified limiting factor adding one cathode unit increased current generation installing additional anode units obviously alter mdc current production changing position anode cathode units exhibited weak influence mdc performance parallel connection electrical circuits generally produced current individual connections strong competition observed multiple units sharing opposite unit elsevier ltd rights reserved
background atlantoaxial posterior pedicle screw fixation widely used treatment atlantoaxial instability aai however precise safe insertion atlantoaxial pedicle screws remains challenging study presents modified drill guide template based previous template atlantoaxial pedicle screw placement material methods study included patients males females aai patients underwent posterior atlantoaxial pedicle screw fixation patients underwent surgery use modified drill guide template template group patients underwent surgery via conventional method conventional group template group modified drill guide template designed patient modified drill guide template intraoperative fluoroscopy used surgery template group intraoperative fluoroscopy used conventional group results patients completed follow months template group significantly lower intraoperative fluoroscopy frequency conclusions based results study feasible use modified drill guide template atlantoaxial pedicle screw placement using template significantly lower screw malposition rate frequency intraoperative fluoroscopy
article presents realization electronically tunable current mode elliptic ladder low pass filter using ccciis passive rlc ladder filters prototype signal flow graph method sfg employed synthesis cccii based lossy lossless integrators current attenuator required circuit realization proposed filter circuit electronically tuned khz mhz bias current proposed filter use power supply power consumption bias current proposed filter uses grounded capacitors without external resistors suitable integration total harmonic distortion thd low pass filters less operating frequency range pspice simulation results carried obtained using bjt model parameter hfa confirm presented theory
vertically aligned carbon nanotubes graphene oxide nanocomposite vacnt prepared applied electrode material first dense packets vacnt prepared microwave chemical vapor deposition reactor functionalized oxygen plasma etching observed oxygen plasma could exfoliate carbon nanotubes tips provide oxygen group attachment surface changing wettability well change wettability vacnt crucial electrochemical application since grown vacnt super hydrophobic exfoliation functionalization electrochemical tests performed using potassium ferrocyanide cyclic voltammetry impedance spectroscopy revealed fast electron transfer kinetics new material peak potential separation suggesting ideal reversibility electrode nyquist bode plots well fitted modified randles equivalent electrical circuits non charge transfer impedance new highly porous nanostructures intensively characterized scanning electron microscopy brunauer emmett teller surface area surface wettability raman ray photoemission spectroscopy results suggest new material relevant potential future applications electrocatalysis bio sensors elsevier ltd rights reserved
purpose patients advanced disease living longer commonly used patient reported outcome measures proms may miss relevant elements quality extended survival systematic review examines measures used capture aspects quality survival including impact patients everyday lives finances work family roles methods searches conducted medline embase cinahl psycinfo restricted english language articles information study characteristics instruments outcomes systematically extracted synthesised predefined set criteria used rate quality studies results potentially relevant articles met inclusion criteria including concerning financial distress roles responsibilities multiple aspects social well generally studies high quality many lacked bias free participant selection confounding factors accounted participants high levels financial distress reported associated multiple demographic factors age income reports concerned impacts patients roles responsibilities everyday life although practical emotional struggles parenting identified social difficulties common associated multiple factors including caregiver many studies single time point surveys used non validated measures exceptions employment cost social difficulties inventory sdi validated measures financial social distress respectively conclusions impact important parts patients everyday lives insufficiently inconsistently captured prom development focussing roles responsibilities including work caring dependents warranted implications cancer survivors factors finances employment responsibility caring dependants children elderly relatives affect well cancer survivors need ensure instruments used assess patients social well broad enough include areas difficulties arising better understood appropriately supported
experimental data multiple studies show coarsening continuous high interfacial tension fluid systems driven capillary instabilities coarsening low interfacial tension systems follows viscosity ratio dependence consistent pinch suspended short filaments although uncertainty interpretation attenuation coarsening rates types follows common dependence phase volume fraction viscosity ratio dimensional analysis provides interpretation transition linear coarsening slower nonlinear coarsening balance interfacial tension driven flow critical level interconnectivity slowdown coarsening consistent formation discrete domains subsequently coexist remaining continuous structure american institute chemical engineers aiche
ever increasing supercomputer architectural complexity emphasizes need high level parallel programming paradigms among paradigms task based programming manages abstract away much architecture complexity efficiently meeting performance challenge even large scale dynamic run time systems typically used execute task based applications schedule computation resource usage memory allocations computation scheduling well studied dynamic management memory resource subscription inside run times however little explored paper studies cooperation task based distributed application code run time system engine control memory subscription levels throughout execution show task paradigm allows control memory footprint application throttling task submission flow rate striking compromise performance benefits anticipative task submission resulting memory consumption illustrate benefits contribution compressed dense linear algebra distributed application
larger displacement inter force response structure produced self anchored cable stayed suspension bridge longitudinal earthquake optimized layout viscous damper done self anchored cable stayed suspension bridge lead rubber bearings main tower moreover nonlinear time history analysis longitudinal seismic input made comparing analysis results scheme viscous damper scheme without isolation measures analysis results show inter force displacement control section control node reduced greatly hybrid vibration control
logic programming essential part many academic curricula extensively employed field artificial intelligence however based fundamentally different paradigm lacking visual tools inexperienced users teaching may lead confusion low student motivation virtual worlds vws may help overcome obstacles successfully used computer programming education paper present meloise platform meaningful logical interpretations simulated environments teaching vws students experience collaborative visual interface prolog programming language also present evaluation meloise conducted learning activity engaged students collaborative programming problem scenarios students performed well enthusiastic new environment
nanotechnology rapidly developing field wide range potential applications one application using nanoparticles selectively absorb transmit light controlling material size shape nanoparticles possible achieve spectrally selective optical properties phenomena exploited solar energy applications selective absorption solar spectrum enables high efficient hybrid photovoltaic thermal collectors study suspend core shell sio nanoparticles water filter ideal spectrum creating electricity cells detailed optical heat transfer model approach developed validated using electric thermal outputs prototype system operating real outdoor conditions results experimental work indicates value weighted energy output achieved prototype compared stand alone system illumination since proposed system inherently decouples thermal receiver cells possible extend technology industrial combined heat power applications elsevier ltd rights reserved
study aimed describe changes disease modifying treatments dmt italian cohort patients multiple sclerosis identify predictors therapeutic modifications patients treated first line injectable dmt interferons ifns glatiramer selected administrative databases center cagliari sardinia italy socio demographic therapeutic clinical information collected months preceding index date patients followed months evaluate therapeutic changes terms non adherence switch temporary discontinuation permanent interruption predictors changes estimated multivariable regression models data patients collected glatiramer prescribed cases ifn beta ifn beta ifn beta mcg ifn beta mcg non adherence observed cases therapeutic switch discontinuation permanent interruption risk non adherence higher ifn beta compared ifn beta adjor therapeutic switch occurred especially patients recently diagnosed year diagnosis causes decrease risk adjhr risk discontinuation higher edss adjhr respectively risk permanent interruption increased augmentation disability adjhr edss study mirrored detailed framework dmt prescription identified factors related changes therapy findings could support healthcare providers evaluation maximization benefits associated long term dmt
energy harvesting become promising alternative solution conventional energy generation patterns overcome problem supplying autonomous electrical systems particularly thermal energy harvesting technologies drawn major interest research industry thermoelectric generators tegs used two different operating conditions constant temperature gradient constant heat flow commonly used teg electrical model based voltage source series electrical resistance shows limitations especially constant heat flow conditions analytical electrical modeling taking consideration internal contact thermal resistances teg constant temperature gradient constant heat flow conditions first given give insight electrical behavior teg module different operating conditions propose new original way emulating analytical expressions usual electronics components voltage source resistors diode whose values determined teg parameters note teg emulation particularly suited designing electronic circuitry commonly associated teg realize maximum power point tracking output voltage regulation first proposed equivalent electrical circuits validated simulation spice environment static operating conditions using one value either temperature gradient heat flow also analyzed dynamic operating conditions temperature gradient heat flow considered time varying functions
extend parikh wilczek method einstein gravity spacetime gauss bonnet modified gravity study tunneling radiation particles across event horizon dimensional gauss bonnet anti sitter black hole emission rate particle calculated shown emission rate massive particles takes functional form massless particles although motion equations tunneling across horizon different also shown emission spectrum deviates pure thermal spectrum consistent underlying unitary theory addition significant interesting phenomenon demonstrated gauss bonnet term present expression emission rate black hole gauss bonnet gravity differs black hole einstein gravity adopting conventional tunneling rate obtain expression entropy gauss bonnet black hole accordance early results obey area law research tunneling radiation paper may serve new perspective understanding thermodynamics black holes gauss bonnet gravity
improve winter wheat yield estimates guanzhong plain china daily leaf area index lai soil moisture depths theta simulated ceres wheat model assimilated field measured lai theta landsat derived lai theta using particle filter algorithm linear regression analyses performed determine relationships assimilated lai theta field measured yields identify highly yield related variables growth stage winter wheat used establish optimal assimilation yield estimation model green milk stages assimilated highly correlated measured yields jointing heading filling stages assimilated lai theta highly correlated yields optimal assimilation yield estimation model established combining regression equations relating assimilated theta yields green milk stages equations relating assimilated lai theta yields jointing heading filling stages resulted better estimation accuracy yield estimation model established based dualistic regression equations relating assimilated lai theta measured yields growth stage moreover establishing different yield estimation models irrigated rain fed farmlands improved yield estimates compared established estimation model take account whether farmlands irrigated rain fed therefore assimilation highly yield related state variables wheat growth stage provides reliable promising method improving crop yield estimates
network intrusion detection systems nids deployed protect computer networks malicious attacks proper evaluation nids requires scrutiny evaluation general network appliances evaluation commonly performed sending pregenerated traffic nids unfortunately technique often limited diversity resulting evaluations incapable examining complex data structures employed nids sophisticated methods generate workload directly nids rules consume excessive resources incapable running real time work proposes novel approach real time workload generation nids evaluation improve evaluation diversity maintaining much higher throughput work proposes generative grammar represents optimized version context free grammar derived set strings matching given nids rule database grammar memory efficient computationally light generating workload experiments demonstrate grammar generated workloads exert order magnitude effort target nids even better improved diversity comes much smaller cost memory speeds four times faster current approaches
study identified predictors anxiety depression patients acute coronary syndrome predictors included illness beliefs fear threat time cardiac event threat reappraisal time social support total participants completed questionnaires hospital month follow perceived threat fear time cardiac event predicted affective response time points partly mediated threat reappraisal contemporaneous measures illness beliefs contributed additional variance although always predicted direction high concern control illness associated emotional distress assessment patients risk negative emotional outcomes acute coronary syndrome needs consider beliefs illness degree threat fear experienced time event interventions need help people cope negative emotional states well challenging inappropriate illness beliefs
weekend effect defines association hospital admissions higher rate mortality aim study evaluate relationship effect renal transplant recipients rtrs using database emilia romagna region err italy included err admissions rtrs international classification diseases ninth revision clinical modification icd code hospital mortality admissions due cardiovascular events cves elixhauser score evaluated basis icd codification hospital admissions related rtrs mean age years male recorded follow period patients deceased cves length hospital stay los days logistic regression analysis showed los independently associated admissions odds ratio confidence interval renal transplant recipients exposed higher risk adverse outcome admissions however admissions characterized increased duration hospitalization
logical positivism potentially leads abstraction social constructivism potentially leads relativism neither perspective full justice study construction management expertise social realism aims recover declarative knowledge theory integral component expertise without denying place deliberate practice issue bridge explicit implicit forms knowledge returning account tacit knowing proposed polanyi nature expertise characterized declarative personal knowledge terms limited characterization expertise social realism enterprise raises number critical issues body knowledge human agency deliberate practice social realism perspective production theory critical exercise expertise theory meaningless context professional practice unless embodied enacted construction management gives purpose value theory
thyroid hormones crucial growth maturation many target tissues especially brain skeleton critical periods first trimester pregnancy maternal thyroxine essential fetal development supplies thyroid hormone dependent tissues ontogeny mature thyroid function involves organogenesis maturation hypothalamus pituitary thyroid gland almost complete gestational week case maternal hypothyroidism substitution levothyroxine must started early pregnancy gestational week fetal brain development may already irreversibly affected lack thyroid hormones prevalence manifest hypothyroidism pregnancy prevalence subclinical hypothyroidism varies strongly depending definition upper tsh cutoff limit hyperthyroidism occurs pregnancies positivity antibodies thyroid peroxidase tpoab common women childbearing age incidence rate tpoab positivity may regarded manifestation general autoimmune state may alter fertilization implantation processes cause early missed abortions women positive tpoab significant risk developing hypothyroidism pregnancy postpartum laboratory diagnosis thyroid dysfunction pregnancy based upon serum tsh concentration tsh pregnancy physiologically lower non pregnant population results multiple international studies point toward creation trimester specific reference intervals tsh pregnancy screening hypothyroidism pregnancy controversial implementation varies country country currently case finding approach screening high risk women preferred countries universal screening however numerous studies shown one third one half women thyroid disorders escape case finding approach moreover universal screening shown cost effective screening thyroid disorders pregnancy include assessment tsh tpoab regardless screening approach review summarizes current knowledge physiology thyroid hormones pregnancy causes maternal thyroid dysfunction effects pregnancy course fetal development discuss question case finding versus universal screening strategies display overview analytical methods reference intervals assessment thyroid function thyroid autoimmunity pregnancy finally present results supporting implementation universal screening
unexpected faults occurring certain conditions renewable energy sources connected power grid may result severe damages capacitive load exists consequently inductive power factor correction applied shunt coils paper presents investigations case study
paper shows classical square triangular wave generator also provide sinusoidal oscillations thus square triangular sinusoidal oscillator obtained topology changing resistance new sinusoidal oscillator using two operational amplifiers one resistor one capacitor also shown experimental results confirm operation proposed circuits different regimes included
introduction wives patients schizophrenia experience high levels stress due spouses disease leads certain problems decreased adaptability efficiency aim study investigated efficacy mindfulness based cognitive therapy mbct resilience schizophrenia patients materials methods quasi experimental study wives patients schizophrenia assigned experimental group control group whose husbands kept rehabilitation centers mental disorders enrolled according convenience sampling experimental group therapeutic protocol mbct conducted accordingly patients encouraged process experiences non judgmental manner formed change relationship embrace challenging thoughts feelings meanwhile control group underwent intervention research instrument connor davidson resilience scale data analysed ancova spss results post test mean resilience score experimental group much higher control group significant difference mean resilience score post test experimental control groups conclusion training mbct strategies effective resilience wives schizophrenia patients therefore approach incorporated mental health related interventions families patients psychiatric disorders schizophrenia
knowing network function pertaining certain input output couple individuated inside linear electrical network len crucial provides synthetic effective description input output relationship allows one derive several key features subject system well devise proper strategies modify mathematical point view may expressed product real number called gain constant real rational function complex variables whose numerator denominator called zero polynomial characteristic polynomial respectively may obtained calculating determinants proper matrices however design oriented symbolic hand analysis needed calculating said polynomials manner may turn tediously cumbersome route may fail illuminate way coefficients depend circuit elements may said numerical computer methods suited providing global description frequency domain rather analytical expressions coefficients paper method proposed permits one obtain without calculating determinants respect methods achieve goal present one require prior calculation nullator norator pair nnp compulsorily inserted subject circuit instead based applying andreani mattisson extension ame cochrun grabel algorithm cga calculation circuit obtained assigned one inserting latter proper dependent source nature new circuit allows worker employ classical tools len theory make analysis simple possible often performable straightforward inspection without need possibly involved equilibrium equations moreover shown technique applied properly modified version original network order calculate well case compulsorily judged convenient simplifying calculations nnp may employed conjunction dependent source proposed method allows one exploit classic tools len theory considerably drastically simplify analysis associated direct application ame original network finally calculation completes knowledge whole study well circuit degeneracy discussed practical examples application proposed techniques given copyright john wiley sons ltd
spanish industrial heritage considered much worse heritage sectors spain industrial heritage countries industrial heritage national plan pnpi first step changing situation much remains done one main needs appropriate methodology categorization classification study industrial heritage assets work develops methodology gives clear criteria application large number selected items four sources different approaches creates catalog allows comparative analysis different perspectives classifies industrial assets clear easy criteria favoring extension catalog whit interest analyses authors published elsevier ltd
paper presents monte carlo approach reliability assessment distribution systems distributed generation using parallel computing calculations carried royalty free power flow simulator opendss open distribution system simulator procedure implemented environment opendss driven matlab test system overhead distribution system represented means three phase model includes protective devices paper details implemented procedure applied systems without distributed generation includes illustrative case study summarizes results derived analysis test system one year goal evaluate test system performance considering different scenarios different level system automation reconfiguration assess impact distributed photovoltaic generation performance several reliability indices including related impact distributed generation obtained every scenario
article examines idea believing events occurred past non memorial decision reflects underlying processes distinct recollecting events research autobiographical memory often focused events believed occurred remembered thus tending overlook distinction autobiographical belief recollection studying event representations false memories believed remembered events non believed memories shows influence non memorial processes evaluations occurrence believing event occurred recollecting event may strongly dissociated previously stated relative independence constructs examined studies study multiple events cued rated autobiographical belief recollection memory characteristics study participants described nonbelieved memory believed memory believed remembered event made similar ratings studies structural equation modeling techniques revealed distinct belief recollection latent variables modeling predictors factors revealed double dissociation perceptual experiencing emotional features predicted recollection belief whereas event plausibility strongly predicted belief weakly predicted recollection results show judgments autobiographical belief recollection distinct influenced different sources information processes strength relationship varies depending type event study concept autobiographical belief elaborated implications findings discussed relation decision making events social influence memory metacognition recognition processes
clinical features atopic dermatitis change age skin homeostatic mechanisms develop cases symptoms persist childhood adult early childhood characteristic features disease eczema exudative papules accompanied itching childhood lichenified dermatitis preceded severe itching major skin manifestation presumably difference clinical symptoms childhood adulthood may derive age specific physiological function skin maintenance proper stratum corneum secretion lipids perspiration volume composition secreted lipids sweat change age changes affect water retention skin surface microbiome physiological activities follow hierarchy instead coordinated harmonize maintenance skin homeostasis thus daily skin care based characteristic age specific physiological function skin considered manage atopic dermatitis usage moisturizers contributes reduce skin dryness incidence atopic dermatitis recommended immediately bathing water temperature degrees bathing beneficial barrier recovery gentle detergents soap chosen necessary exercise excess sweat skin surface rinsed avoidance perspiration inducing activities necessary high temperature humidity skin surface may cause development miliaria subsequent anhidrosis wearing hygroscopic breathable underwear recommended
background palliative care recommended means assist patients idiopathic pulmonary fibrosis ipf managing symptom burden advanced care planning timing referral important although patients display gradually progressive course minority experience acute deterioration outcome associated high mortality aim describe characteristics ipf patients referred specialty lung disease center year period experienced acute deterioration subsequent intensive care unit icu admission including frequency timing referral palliative care design retrospective review setting participants identified patients admitted icu acute deterioration due respiratory nonrespiratory cause variables examined included demographics date first center visit forced vital capacity diffusing capacity lung carbon monoxide dlco palliative care referral results icu admission occurred early median months within four months first center visit nearly one half patients icu admission occurred third clinic visit patients received palliative care referral icu admission majority died icu admission exception relationship dlco predicted first visit time icu admission variables identified likely experience acute deterioration conclusion due high mortality associated icu admission patients families informed palliative care early following diagnosis ipf
background hereditary angioedema due inhibitor deficiency inh hae may affect health related quality life hrqol specific hrqol questionnaire adult patients inh hae hae qol recently developed spain objective objective study perform cross cultural validation psychometric study hae qol international setting methods cross cultural adaptation spanish hae qol draft version international rating phase experts performed resultant version hae qol clinical questionnaire short form item health survey version pilot tested internationally item reduction based descriptive exploratory factor analysis psychometric properties assessed results cross cultural adaptation hae qol performed countries draft version hae qol pilot tested patients accurate data obtained patients countries reduction process resulted new version items dimensions treatment difficulties physical functioning health disease related stigma emotional role social functioning concern offspring perceived control illness mental health strong psychometric properties observed cronbach alpha test retest reliability convergent validity showed mild moderate correlations physical mental component summaries respectively dimensions hae qol scores discriminated significantly among severity groups median asymptomatic severe patients without long term prophylaxis median patients without psychiatric psychological care median conclusions hae qol currently available languages showed good reliability validity evidence american academy allergy asthma immunology
geotextiles widely promoted pavement structures past years previous studies show geotextile placed subgrade base course interface paved road increase number load repetitions rutting failure thus reduction base asphalt thickness may possible however lack well instrumented full scale experiments investigate effect geotextile reinforcement possible mechanisms pavement failure like fatigue hot mix asphalt hma layer study full scale accelerated pavement testing done eight pavement test sections six eight sections base layers reinforced different types woven geotextiles reinforced sections control sections unreinforced base paved superpave hma layers base subgrade materials sections test sections different asphalt base layer thicknesses test section instrumented six bar strain gages bottom hma layers measure longitudinal transvers strains mechanistic response section monitored analysed selected number wheel passes predicted fatigue lives test sections calculated based asphalt institute shell models results indicate fatigue life test sections increase due geotextile reinforcing although rutting performance reinforced sections improve may indicate geotextiles may improve fatigue performance hma layers pavements
background mice models suggest epigenetic inheritance induced parental allergic disease activity however know little parental disease activity conception influences offspring asthma allergy humans objective aimed assess associations parental asthma severity bronchial hyperresponsiveness bhr total specific iges measured conception birth offspring asthma hayfever methods study included participants mean age men european community respiratory health survey ecrhs information asthma symptom severity bhr total specific iges data offspring born adjusted relative risk ratios arrr associations parental clinical outcome offspring allergic disease estimated multinomial logistic regressions results offspring asthma hayfever strongly associated parental bhr specific ige measured conception birth bhr arrr respectively specific iges respectively confirmed sensitivity analysis subgroup offspring aged years information parental disease activity birth conclusion clinical relevance parental bhr specific ige associated offspring asthma hayfever strongest associations observed clinical assessment conception compared birth child hypothesis confirmed studies parental disease activity assessed conception may prove useful identifying children risk developing asthma hayfever
introduce ultra dense network architecture designed silicon photonics optical network unit onu network relies gsa msa converters olt onu respectively offers gbit symmetric traffic single ghz optical channel multiple access lowest processing speeds onu enabled choosing dft spread ofdm subbands demonstrate fdma network architecture proof principle experiment eight mbd qam subbands offering bidirectional data rate real time signal processing realized stream transmission finally shortly address future improvements network architecture employing integrated silicon photonics analog signal processing enable fine fdm next generation access networks
spreading depolarizations waves near complete breakdown neuronal transmembrane ion gradients free energy starving mass depolarization spreading depolarizations electrically inactive tissue associated poor outcome patients traumatic brain injury studied changes regional cerebral blood flow brain oxygen pbto glucose glc lactate lac concentrations rats using minimally invasive real time sensors rats underwent either spreading depolarizations chemically triggered kcl naive cortex absence traumatic brain injury spontaneous spreading depolarizations traumatic penumbra traumatic brain injury cluster spreading depolarizations triggered chemically kcl remote window spreading depolarizations invaded penumbral tissue spreading depolarizations noninjured cortex induced hypermetabolic response characterized decline glc monophasic increases regional cerebral blood flow pbto lac indicating transient hyperglycolysis following traumatic brain injury spontaneous spreading depolarizations occurred causing decline glc reducing increase regional cerebral blood flow biphasic responses pbto lac followed prolonged decline recovery pbto lac significantly delayed traumatized animals prespreading depolarization glc levels determined metabolic response clusters results suggest compromised hypermetabolic response spreading depolarizations slower return physiological conditions following traumatic brain injury induced spreading depolarizations
designing local feature descriptors objects fundamental yet challenging task computer vision geometry spatial information descriptions critical local descriptor previous studies concentrate former one paper investigates characterization spatial information would affect local descriptor terms descriptiveness robustness compactness efficiency evaluation process deployed follows first based analysis representative spatial information characterization methods existing local shape descriptors six typical characterization methods different spatial dimensions partition principles spatial information presented second three geometric attributes normal deviation local depth shape index respectively assigned point local surface local geometry description creating total different feature descriptors quantitative analysis performance descriptiveness robustness compactness efficiency descriptors carried three benchmark datasets grounded experimental outcomes traits merits demerits spatial information encoding approach eventually summarized study reveals different spatial information encoding approaches would bring significant effect local shape descriptor respect discriminative power stability compactness efficiency
paper presents controlled experiment goodness using theory belbin roles integration software development teams explored study takes place academic environment students engineering software compares quality readability code generated integrated teams roles compatible according theory belbin traditional teams case integrated teams students selected randomly results provide positive evidence use theory motivate researchers continue studies activities related software development process hand pedagogical perspective results obtained experiment allow proposing alternative integration teams learning scenarios related courses software engineering theory roles belbin
aim study determine amazon river prawn macrobrachium amazonicum heller population structure affected habitat heterogeneity experiment conducted mesocosms emulate conditions natural aquatic environment twelve rectangular earthen ponds similar used mesocosins mesocosm stocked juveniles amazon river prawn three different treatments mesocosm substrate made geotextile blanket mesocosm substrate made bamboo mesocosm without substrate prawns sampled monthly analyze male morphotypes incidence eggs female pleopods ovarian stage body mass sex ratio geotextile blanket bamboo substrates increased frequency cinnamon claw morphotype accelerated appearance green claw morphotypes decreased frequency translucent claw morphotype ffi substrates also increased size sexes prawn increased frequency ovigerous females females ovarian stages effect pronounced presence imitates natural substrates large fiat surfaces leaves stones sex ratio differ significantly treatments data showed presence type substrate environment play important role amozonicum population development supporting hypothesis population structure amazonicum depends habitat characteristics
paper reviews recent developments power loss analysis applicable limited thermal design permanent magnet machines accurate computationally efficient loss prediction essential element thermal analysis electrical machines become increasingly important part machine design process continuous drive toward electric technologies resulted need comprehensive detailed design approach various multiphysics multidisciplinary effects accounted design application methodology relies strongly advancements evolution existing theoretical experimental design techniques satisfy evermore demanding machine design requirements thermal behavior efficiency power conversion essential performance measures design application approach overview challenges limitations regarding power loss analysis context thermal design electrical machines provided paper major loss components associated active parts machine assembly discussed
globally increasing pressure schools enact change literature indicates transformational leadership positively associated school leaders effectiveness implementing positive reforms report study conducted united arab emirates uae within current context intense educational restructuring system purpose investigate whether school principals uae practise transformational leadership whether teachers perceived principals leadership styles differently western counterparts study adopted mixed methodology revealed variation perceptions principals teachers related whether principals practising transformational leadership however analysed using hofstede cultural framework variation may related cultural differences western orientation leadership model adapted emirati principals islamic orientation population therefore new model transformational leadership proposed based paradigm may appropriate middle eastern islamic contexts modified transformational model may useful leaders wish adopt transformational leadership cultural accommodations
study noncontact main cable nde method developed cable nde method utilizes direct current magnetization searching coil based total flux measurement total flux sensor head prototype fabricated consists electro magnet yoke searching coil sensor obtain loop magnetic field generated applying cycle low frequency direct current electro magnet yoke magnetization search coil sensor measures electromotive force magnetized cable magnetization process search coil sensor measured magnetic flux density total flux calculated integrating measured magnetic flux using fluxmeter loop obtained using relationship cycle input voltage measured total flux loop reflect property ferromagnetic materials therefore cross sectional loss cable detected using variation features curve verify feasibility proposed steel cable nde method series experimental studies using main cable mock specimen performed study
present study describes series primary soft tissue lymphomas including immunohistochemical characterization tissue microarray cytogenetic profiling formalin fixed paraffin embedded tissue samples collected patients underwent soft tissue biopsy cases selected according definition primary soft tissue lymphoma lymphoid malignancy arising soft tissues without evidence nodal extranodal localization period least months series comprised seven patients mean age years three diffuse large cell lymphomas dlbcls one cell lymphoma unclassifiable features intermediate dlbcl burkitt lymphoma one dlbcl derived follicular lymphoma one alk negative anaplastic large cell lymphoma one follicular lymphoma immunohistochemical molecular profiles consistent histological diagnoses present study contributes knowledge uncommon presentation lymphoid neoplasms confirms previously published clinical pathological data present first time complete immunohistochemical profile molecular cytogenetic studies lymphoid neoplasms rare case primary soft tissue alk negative anaplastic large cell lymphoma described detail
aim management fistulating perianal crohn disease fpcd significant challenge colorectal surgeon recent survey surgical practice condition showed variation management approaches result set devise recommendations practice colorectal surgeons method results national survey used devise set potential consensus statements consultant colorectal surgeons invited participate exercise via previous survey mailing list professional society iterative voting performed statement using five point likert scale electronic voting opportunity discussion refinement vote consensus defined agreement results seventeen surgeons two patient representatives voted upon statements consensus achieved items participants advocated patientcentred approach colorectal specialist within strong multidisciplinary teamworking use anti tnf alpha therapy advocated definitive surgical techniques considered carefully selected avoid adverse impact function ano rectovaginal fistulas managed specialists fistulating disease stoma proctectomy could discussed earlier patient treatment pathway improve choice may improve quality life conclusion consensus provides principles guidance best practice managing patients fpcd
attacks web based applications one serious network security threats present web based attacks complex single detection method unable cope emerging attacks motivated efficiently merge misuse detection anomaly detection propose hybrid model web log intrusion detection considering web log request contains majority attack features propose method extract feature vectors http request distinguish abnormal behaviors users particularly construct normal access model based request feature vectors using means clustering algorithm test data indicate compared single intrusion detection model hybrid intrusion detection model proposed effectively improve detection rate reduce false alarm rate
accurate determination protons energy radiotherapy planning achieved stopping power protons specific body tissue known bethe bloch equation greatly aid understanding calculate stopping power physics point view practical easy applied radiotherapy planning system involves many computational calculations computer programming paper present numerical equation mass stopping power protons four types human body substance water bone muscle tissue equation obtained fitting data values obtained srim program using numerical equation algorithm programming expected become simpler easier
purpose review review addresses development new solid state lighting system international space station iss intended enhance illumination working living environment astronauts improve sleep circadian entrainment daytime alertness recent findings spaceflight missions often expose astronauts mission support ground crews atypical sleep wake cycles work schedules recent extensive study describes sleep characteristics use sleep promoting pharmaceuticals astronauts spaceflight acceptability feasibility efficacy new iss solid state lighting systems currently tested ground based analog studies installation lighting system iss scheduled begin later year flight testing lighting system planned take place iss spaceflight expeditions summary new iss lighting system capable improving circadian entrainment sleep spaceflight enhance astronaut health performance well safety advance would open door future lighting applications humans living earth
modern distributed systems require fast scalable datastores efficient processing huge amounts information traditional dbmss insufficient purpose hence new datastore models developed paper present design implementation scalable distributed two layer block based datastore also discuss experimental results comparing performance datastore mongodb widely used nosql datastore
background alcohol substance use disorders sud pose major problems morbidity mortality american indian communities little known clinical characteristics risk factors consequences combined alcohol substance use disorders multi substance use disorder msud communities methods using semi structured assessment genetics alcoholism ssaga community sample american indians clinical characteristics lifetime dsm moderate severe alcohol use disorder alone aud alone msud defined alcohol sud evaluated compared participants lifetime sud sud results majority participants sud multi substance use disorder aud stimulants cocaine amphetamine cannabis common suds participants aud alone likely male earlier age first alcohol intoxication sud msud likely dropped high school antisocial personality disorder aspd conduct disorder earlier ages first alcohol intoxication first use cannabis stimulants earlier age onset aud several aud symptoms aud alone temporal course time remission aud conclusions msud prevalent sample associated multiple comorbidities denotes severe alcohol syndrome aud alone elsevier ireland ltd rights reserved
present work effect nonlinear void reactivity dynamics simplified lumped parameter model boiling water reactor bwr investigated mathematical model five differential equations comprising neutronics thermal hydraulics encompassing nonlinearities associated reactivity feedbacks heat transfer process used end considered parameters relevant rbmk void reactivity known nonlinear nonlinear analysis model exploiting method multiple time scales mmts predicts occurrence two types hopf bifurcation namely subcritical supercritical leading evolution limit cycles range parameters numerical simulations performed verify analytical results obtained mmts study shows nonlinear reactivity significant influence system dynamics parametric study varying nominal reactor power operating conditions coolant channel also performed shows effect change concerned parameter boundary regions sub super critical hopf bifurcations space constituted two coefficients reactivities viz void doppler coefficient reactivities particular find introduction negative quadratic term void reactivity feedback significantly increases supercritical region dominates determining system dynamics elsevier rights reserved
study real time estimation flow rate pressure along natural gas pipelines transient flow condition aimed estimation internal states gas pipelines based recursive discrete data filtering algorithm called discrete kalman filter state space representation transient flow gas pipelines required filtering algorithm established discrete form nonlinear partial differential equations pde describing characteristics transient gas flow pde discretized finite element method implicit scheme employed order obtain simple adequate algebraic set equations transient gas flow state estimator uses linearized equations estimation phase performed using simulated data imitating measurements motivation work estimate actual state flow online data applying discrete state space model flow therefore estimator developed situation pressure measurements points along pipe one flow rate data outlet end pipe available moreover improve performance estimator state estimation pair kalman filter based estimators running parallel also proposed performance state estimations tested case study literature developed estimator predict simulated states even incomplete faulty information system parameters elsevier rights reserved
become increasingly clear gut microbiota influences gastrointestinal physiology also central nervous system cns function modulating signalling pathways microbiota gut brain axis understanding neurobiological mechanisms underpinning influence exerted gut microbiota brain function behaviour become key research priority microbial regulation tryptophan metabolism become focal point regard dual emphasis regulation serotonin synthesis control kynurenine pathway metabolism focus detail latter pathway begin outlining structural functional dynamics gut microbiota signalling pathways brain gut axis summarise preclinical clinical investigations demonstrating gut microbiota influences cns physiology anxiety depression social behaviour cognition visceral pain pertinent studies drawn neurogastroenterology demonstrating importance tryptophan metabolites cns gastrointestinal function outline kynurenine pathway metabolism may regulated microbial control neuroendocrine function components immune system finally preclinical evidence demonstrating direct indirect mechanisms gut microbiota regulate tryptophan availability kynurenine pathway metabolism downstream effects cns function reviewed targeting gut microbiota represents tractable target modulate kynurenine pathway metabolism efforts develop approach markedly increase understanding gut microbiota shapes brain behaviour provide new insights towards successful translation microbiota gut brain axis research bench bedside article part special issue entitled kynurenine pathway health disease elsevier ltd rights reserved
paper presents design philosophy design induction machine drive minimized torque ripples induction motor model derived incorporate effect machine design parameter ripple producing cause torque response harmonics flux density wave due distribution winding around air gap periphery due slot permeance effect considered together modeled ripple producing cause torque response classical approach induction machine modeling mutual inductance calculation adopted large ripples identified torque response derived model simulation order minimize torque ripples model subjected heuristic based optimization technique optimization torque ripple minimization suggested new values design parameters next feasibility condition design parameters checked optimized design parameters rounded nearest feasible design values induction machine model response feasible design values determined model simulation torque ripple reduced negligible value optimized machine model
investigated consistency relationship memories college undergraduates described five events first meeting first date first fight embarrassing event favourite memory current relationship currently dating recent relationship three months later asked describe events scored consistency narratives three levels analysis event basic information propositions participants demonstrated low consistency descriptions particularly detailed levels analysis consistency depended somewhat events recalled participants consistent commonly retrieved relationship memories first dates also found individuals continued relationship less consistent describing previous relationship still dating couples increased opportunities narrate event stories together update knowledge relationship new episodes fashion updating experiences may led inconsistencies recall time considered research flashbulb memories findings indicate updating revisions may general features autobiographical memory
paper presents ultra low power low voltage class fully differential operational amplifier designed cmos technology proposed circuit uses transistors operating sub threshold region low power low voltage operation proposed amp offers open loop gain mhz unity gain frequency degrees phase margin common mode rejection ratio loads power consumption supply simulation results illustrate slew rate rail rail output swing demonstrating correct functionality
industries fast moving consumers good fmcg products usually transferred high volume low value comparing value market share important paper research relationship total unit sold changes price market share specific company industry hope research may help company decide product strategy based whether existing products contribution market shares necessary product need discontinued replaced report measure relationship total products sold changes price market share derived proportion values compared total market value skin care market multiple regression analysis used formulate relationship using ordinary least square ols estimation method concluded number unit sold product relationship market share regression model regardless contribution significance prices changes significantly impacting changes market shares caused loyalty customer towards brand word loyal customers buy product matter much price changed
molybdenum disulfide particular edges attracted considerable attention possible substitute platinum catalysts hydrogen evolution reaction complex nature reaction complicates detailed experimental investigations mostly indirect sample dependent therefore density functional theory calculations employed study properties mos edge influence thermodynamics hydrogen adsorption onto edge effect computational model one dimensional nanostripe border symmetry imposed length sulfur saturation edge dimensionality material discussed hydrogen adsorption found depend critically coverage extra sulfur edge bare edge fully sulfur covered edge catalytically inactive favorable hydrogen binding towards found edge covered sulfur monomers edge provides hydrogen adsorption free energies positioned around hydrogen coverage close experimental values overpotential needed reaction
objective determine prevalence urinary incontinence factors associated sample brazilian middle aged women cross sectional study conducted september june women defined complaint involuntary loss urine independent variables sociodemographic data health related habits problems statistical analysis carried using chi squared test poisson regression mean age years prevalence stress urinary incontinence urinary urgency mixed urinary incontinence final statistical model self perception health fair poor poor vaginal deliveries higher body mass index vaginal dryness current previous hormone therapy pre perimenopause previous hysterectomy associated greater prevalence current previous use soy products treat menopausal symptoms associated lower prevalence several factors associated middle aged brazilian women results highlight importance carrying interventions aimed reducing modifiable factors
weight loss surgery mechanically restricts consumers bodies limit food intake booming context globesity world health organization based foucauldian analysis study contends self transformative experiences arise normalizing practices advocates repressive medical bio power overlook article problematizes idea resistance normativity emphasizing existence various forms agency predicated term resistance author proposes embodied transformation escaping docile embodiment versus embodied resistance negative view subjectification subjecting tell normalizing practices become locus discovery creative potentialities within restrictive contexts study detects two types agency consumers discourses driven temporal narrative structure spatial connective form becoming elsevier inc rights reserved
gastrointestinal parasite survey stray refuge dogs sampled four geographical climactically distinct locations india revealed animals represent significant source environmental contamination parasites pose zoonotic risk public hookworms commonly identified parasite dogs sikkim mumbai delhi ladakh experiences harsh extremes climate competitive advantage observed parasites sarcocystis spp taenia hydatigena echinococcus granulosus utilise intermediate hosts completion life cycle pcr identified ancylostoma ceylanicum ancylostoma caninum occur sympatrically either single mixed infections sikkim northeast mumbai west delhi caninum species identified dogs probably owing ability evade unfavourable climatic conditions undergoing arrested development host tissue expansion known distribution ceylanicum west far mumbai justifies renewed interest emerging zoonosis advocates surveillance future human parasite surveys interest absence trichuris vulpis dogs support previous canine surveys india study advocates continuation birth control programmes stray dogs undoubtedly spill effects reducing levels environmental contamination parasite stages particular owners pet animals exposed environments must extra vigilant ensuring animals regularly dewormed maintaining strict standards household personal hygiene elsevier rights reserved
following market reforms vietnam transformed poor closed economy low middle income economy like developing countries economic growth placed significant pressure infrastructure environment particularly pressure increasing housing demand energy consumption waste pollution management response development challenges green movement globally government initiated actions promote green building promote sustainable development however green building adoption vietnam still criticised slow lacking governmental support paper proposes promoting green building could solve three inter connected challenges hindering sustainable development provides comparative review progress authors published elsevier ltd
objectivesseptoplasty one frequently performed rhinologic surgeries complications include nasal bleeding pain headache septal hematoma synechia infection residual septal deviation septal perforation study aimed compare complication rates among patients according packing method methodswe performed literature search using pubmed embase cochrane library august systematic review followed preferred reporting items systematic reviews meta analyses guidelines random effect models used calculate risk differences risk ratio confidence intervals cis cases referred nonpacking group included patients treated transseptal sutures septal splints cases referred packing group included patients treated nonabsorbable packing merocel gauze resultsour search included randomized controlled trials rcts total subjects nonpacking group subjects packing group significant differences packing methods regarding bleeding hematoma perforation infection residual septal deviation risk differences postoperative pain headache postoperative synechia respectively conclusionsnonabsorbable nasal packing effective treatments without packing septoplasty septal splints transseptal sutures reduce postoperative pain headache synechia level evidenceb laryngoscope
purpose purpose paper explore non technical overview leaders researchers use communications perspective better assess design use digital health technologies dhts improve healthcare performance encourage research implementation use technologies design methodology approach narrative overview showing examples issues benefits introducing dhts healthcare performance insights communications science brings design use findings communications research revealed many ways people communicate non verbal ways lost degraded digitally mediated forms losses often recognized increase risks patients reduce staff satisfaction yet digital technologies also contribute improving healthcare performance staff morale skillfully designed implemented research limitations implications researchers provided introduction limitations research communications science contribute multidisciplinary research approach evaluating assisting implementation technologies improve healthcare performance practical implications using overview managers able ask questions new dhts affect healthcare take stronger role implementing technologies improve performance originality value new insights use understanding dhts applying new multidiscipline communications science situated communications perspective helps assess new technology complement rather degrade professional relationships safer implementation use technologies devised
key issue fruit export classification sorting acceptable marketing present work image processing technique employed grade three varieties oranges bam khooni thompson separately reason choosing fruit object study abundant consumption worldwide study parameters extracted area eccentricity perimeter length area blue value green value red value width contrast texture width area width length roughness length anfis adaptive network based fuzzy inference system method utilized estimate orange mass data obtained using image processing three varieties anfis model samples divided two sets one training set one testing set results present study demonstrated coefficient determination best model bam khooni thompson measured respectively addition results indicated estimation accuracy best model bam khooni thompson measured respectively result satisfactory application anfis estimate orange mass
article presents results investigation wind induced resonance hangers long span suspension bridge data field observations numerical simulations wind tunnel experiments presented article show hangers experience buffeting induced resonance oscillations source excitation buffeting main cables hangers attached dense natural frequencies main cables broad spectrum structural buffeting takes place appears oscillations occur energy transferred main cables hangers hence main cables rather hangers trap energy oncoming turbulent wind field numerical results presented indicate resonance hangers could sensitive positions along bridge deck wind speeds damping ratios article also includes results simplified wind tunnel experiments verified kind resonance disregarding whether wind loads developed directly hanger
purpose lesbian gay bisexual transgender lgbt individuals significantly likely smoke compared heterosexual cisgender counterparts purpose study explore barriers facilitators smoking cessation readiness among lgbt smokers methods descriptive study used qualitative approach four minute focus groups eligibility criteria age self identify lgbt current smoker interest quitting smoking conducted participants also completed brief survey measured additional demographic characteristics smoking behaviors topics explored included quit experiences attitudes beliefs barriers facilitators cessation cultural factors related smoking behaviors established qualitative methods used conduct focus groups data analysis results mean age participants years majority identifying male sample group racially diverse african american white one race interest quitting high range barriers smoking cessation fell broad themes individual level factors cultural factors psychosocial factors access treatment facilitators smoking cessation included stage readiness health concerns social stigma shift social norms financial costs improving dating prospects conclusions interest smoking cessation high sample lgbt smokers influenced range facilitators nevertheless several general culturally specific barriers smoking cessation readiness identified study results implications future research development outreach prevention treatment programs
objectives hypothesis determine whether parent perceived hearing problems associated grade repetition among children united states study design retrospective cohort analysis contemporary national database methods national survey children health analyzed hearing loss perceived reported parents categorized hearing problem history hearing problem current hearing problem children never repeating grade versus repeating one grades kindergarten high school identified univariate statistics multivariate logistic regression analyzed association hearing problems grade repetition patients mental retardation autism attention deficit hyperactivity disorder excluded analysis adjusting race sex poverty level odds ratios grade repetition computed results among million average age years male children never hearing problem history hearing problem current hearing problem overall repeated grade grade repetition reported children without hearing problem versus history hearing problem current hearing problem adjustment race poverty level sex history hearing problem demonstrated odds ratio confidence interval grade repetition whereas current hearing problem demonstrated odds ratio conclusion parents perception children hearing problems strongly associated grade repetition trend noticed elementary school high school
sabkha inferior indigenous type soil forms widely arabian gulf many parts saudi arabia especially coastal areas several studies last years conducted develop better understanding characterization sabkha soil improve strength durability different studies different perspectives different geographical locations particular types discussed specific treatment improvement main purpose study conclude saudi arabian sabkha soil characteristics associated problems recapitulate current technologies practices improvement relative advantages drawbacks currently available techniques also discussed scope future development regarding field also summarized preloading technique found effective stabilization consolidation sabkha soil longer period time another study revealed characterizing saudi arabian sabkha soil using seismic refraction technique comparative research studied focused improvement sabkha soil road construction using geotextile cement additives results suggest techniques similar effect improvement subgrade geotextile application economical compared others geotextile grade greater strength thickness exhibits higher load carrying capability leads less deformation settlement subgrade
backgroundvaluable insights health behavior transit workers obtained qualitative research considers social environment affects job performance determines levels perceived stress methodsusing grounded theory approach semi structured interviews conducted american transit workers recorded interviews transcribed analyzed using constant comparative method resultsparticipants described categories related entrenched organizational practices particularly managements leadership style created atmosphere distrust high demanding work schedules result technological advances discussed relation diminished breaks fatigue unhealthy diets transit workers also attributed increased work demands irregular working hours compromised time family friends conclusionsthe described barriers positive health behaviors social support underscore need interventions ensure adequate breaks recovery shifts increase safety transit passengers ind med wiley periodicals inc
introduction hypogonadism men often associated poor libido erectile dysfunction irritability fatigue psychological relationship problems many symptoms best assessed patient report item hypogonadism impact symptoms questionnaire developed evaluate hypogonadism symptoms men low testosterone context clinical trials aim develop briefer version could practical use treatment settings methods participants low testosterone levels symptoms consistent hypogonadism recruited clinical sites focus groups interviews conducted elicit symptom concepts identify relevant patients including changes consequence treatment main outcome measures systematic analysis qualitative data expert clinician input used develop short form one one cognitive interviews conducted confirm content validity results thirty five men participated qualitative research concept elicitation conducted focus group discussions telephone interviews draft evaluated cognitive interviews mean age total sample years mean serum total testosterone level results suggest demonstrated content validity including content coverage comprehensibility appropriateness response options recall period final version includes items aligned original longer version instrument conclusion comprehensive measurement hypogonadism symptom severity men content coverage content validity confirmed instrument evaluated establish psychometric characteristics assess utility measurement clinical treatment settings copyright authors published elsevier inc behalf international society sexual medicine
assess specific imaging characteristics irreversible electroporation ire locally advanced pancreatic carcinoma lapc contrast enhanced mri cect explore correlation characteristics development recurrence qualitative quantitative analyses imaging data performed patients treated percutaneous ire lapc imaging characteristics ablation zone cect cemri assessed month follow period contrast ratio scores pre post treatment compared detect early imaging markers treatment failure attenuation characteristics weeks linked area recurrence within months post ire diffusion weighted imaging dwi signal intensities decreased cases cemri cect revealed absent decreased contrast enhancement hyperintense rim cemri ablation zone volume increase noted modalities first weeks followed decrease patients developing tumour recurrence focal dwi hyperintense spot weeks predated unequivocal recurrence remarkable signal alterations pancreatic ire shown dwi cemri early imaging characteristics may useful establish technical success predict treatment outcome aeuro cent study describes imaging characteristics irreversible electroporation ire pancreatic adenocarcinoma aeuro cent familiarity typical post ire imaging characteristics helps interpret ablation zones aeuro cent post ire central variable rim enhancement visible contrast enhanced imaging aeuro cent dwi may prove useful predict early tumour recurrence aeuro cent post ire examinations reveal initial volume increase followed decrease
paper possibility using metrology micro computed tomography assess quality parts made rapid prototyping technique presented additive manufacturing techniques dramatically change approach manufacturing process long ago allowed solely obtaining spatial model part order visualize features nowadays possible produce elements assembly groups properties make possible replace many parts manufactured using traditional casting injection techniques polymer components created means printing generated one layer material another many cases inner spaces sections fully filled solid rather replaced specially selected structure thanks possible save material reduce weight control structures inspect joints particular layers using non destructive method necessary use metrology micro paper application ray computed tomography assessment measurement uncertainty regarding elements manufactured fused deposition modeling fdm method using abs printing printer presented inspection inner structure outer shapes well joints performed basing computer aided design cad model
multiple sclerosis chronic disorder affects central nervous system myelin however radiological cases documented involvement peripheral cranial nerves within subarachnoid space patients report case year old female history relapsing remitting consulted subacute complete paralysis right iii nerve magnetic resonance imaging mri examination showed enhancement thickening cisternal right iii nerve continuity linear mesencephalic acute demyelinating lesion radiological involvement cisternal part iii nerve reported patients radiological involvement cisternal part nerve occurs frequently almost patients situations presence central demyelinating lesion continuity enhancement peripheral nerve suggests peripheral nerve damage secondary process rather primary target demyelination
birefringent optical bers propagation femtosecond soliton pulses described coupled higherorder nonlinear schrodinger equations paper investigate bright dark soliton solutions dimensional coupled higher order nonlinear schrodinger equations aid symbolic computation hirota method basis soliton solutions test discuss interactions graphically solitons planes
significant correlation exists violence schizophrenia scz recent studies matched sonic cognitive deficits like strong risk factors violence interesting applications terms treatment objective conduct systematic review effectiveness cognitive remediation social cognitive training sct management violent aggressive behaviors scz methods electronic databases pubmed web science cochrane library sciencedirect searched using combinations terms relating scz violence studies selected data extracted using prisma statement inclusion criteria adults scz documented collection disruptive violent behaviors researchers used sct program results eleven studies identified two related non specific intervention nine codified sct programs results showed programs positive impact control reduction global aggressive attitudes physical assaults therapeutic targets social cognition executive functions improvement interpersonal relationships impulsivity feature respectively effectiveness proved various stages illness different types patients units effects persisting months interruption conclusions limited methodological restrictions conclusion although current evidences need completed randomized studies sci appear promising approaches management violence scz
thyroid hormones play fundamental role diverse processes including cellular movement cell migration requires integration events induce changes cell structure towards direction migration actions driven actin remodeling stabilized development adhesion sites extracellular matrix via transmembrane receptors linked actin cytoskeleton focal adhesion kinase fak non receptor tyrosine kinase promotes cell migration invasion control focal adhesion turnover work demonstrate thyroid hormone triiodothyronine regulates actin remodeling cell movement breast cancer cells recruitment fak controls fak phosphorylation translocation sites focal adhesion complexes assembled process triggered via rapid signaling integrin alpha beta src phosphatidylinositol kinase pik fak addition established cellular model different concentration levels normal absence excess breast cancer cells found expression src fak pik remained normal levels excess model significantly reduced absence model conclusion results suggest novel role important modulator cell migration providing starting point development new therapeutic strategies breast cancer treatment
paper presents moderated target assembly design study minor actinide transmutation first stage sodium cooled fast reactor reduce amount sent second stage accelerator driven system ads two stage ads fuel cycle option order minimize local power peaking problem induced moderated target assemblies target assemblies loaded reflector region using target composition zrh moderator optimum target assembly design developed maximize destruction within practical thermal design limits cladding inner wall temperature long lived fission product pins used thermal neutron filters reduce local power peaking adjacent fuel assemblies due thermal neutron leakage moderated target assembly performance characteristics moderated target assemblies evaluated performing detailed neutronics thermal hydraulics analyses analysis results showed use target assemblies reduces amount sent ads factor six without deteriorating safety characteristics result electricity sharing ads nuclear park composed frs adss reduced elsevier ltd rights reserved
paper cryptanalyses symmetric key image encryption scheme proposed mrinal encryption scheme proposed mrinal uses rossler chaotic system generating three chaotic sequences used creating cipher image secret key bits used generate initial conditions rossler chaotic system equations used generating initial conditions mrinal encryption scheme got loophole loophole utilized carry cryptanalysis cipher image generated using mrinal encryption scheme simulation results show encryption scheme easily cryptanalysed revealed exact plain image improved version proposed statistical security analyses ascertain practicability encryption scheme elsevier gmbh rights reserved
ethnopharmacological relevance notopterygium incisum ting chang known chinese qianghuo traditional chinese medicinal herb rhizome roots associated meridians kidney urinary bladder pungent bitter warm nature used years disperse cold prevent painful obstructions wind damp warm pain also used herbs treat wind cold exterior syndrome wind cold damp syndromes known grow well regions high altitude gansu tibet etc aim review systematic review focuses ethnopharmacological uses herb including recent advances phytochemical pharmacological study incisum recent analytical methods developed quantitative qualitative determination constituents herb also reviewed additionally future trends prospects study herb proposed materials method various literature electronic databases pubmed science direct springer wiley etc searched data obtained online academic libraries google scholar ethnopharmacological literature searched systematically information herb results review focuses ethnopharmacological uses incisum also various chemical constituents present herb various therapeutic effects analgesic anti inflammatory anticancer antioxidants effects analytical methods developed quantitative qualitative determination various compounds herb reviewed conclusion paper reviewed various researches conducted incisum especially areas ethnopharmacological use phytochemicals pharmacology developed analytical methods herb used years treating headache rheumatoid arthritis cold diaphoretic etc prompting many types research identifying compounds responsible activities mechanism action research needed area pharmacokinetics toxicology give information clinical use control quality herb
multiple randomized controlled trials rcts assessed effects supplementation eicosapentaenoic acid plus docosahexaenoic acid omega polyunsaturated fatty acids commonly called fish oils occurrence clinical cardiovascular diseases although effects supplementation primary prevention clinical cardiovascular events general population examined rcts assessed role supplementation secondary prevention among patients diabetes mellitus prediabetes patients high risk cardiovascular disease prevalent coronary heart disease scientific advisory take clinical approach focus common indications omega polyunsaturated fatty acid supplements related prevention clinical cardiovascular events limited scope review large rcts supplementation major clinical cardiovascular disease end points meta analyses considered secondarily discuss features available rcts provide rationale recommendations use existing american heart association criteria assess strength recommendation level evidence basis review cumulative evidence rcts designed assess effect omega polyunsaturated fatty acid supplementation clinical cardiovascular events update prior recommendations patients prevalent coronary heart disease offer recommendations data available patients clinical indications including patients diabetes mellitus prediabetes high risk cardiovascular disease stroke heart failure atrial fibrillation
background prevalence musculoskeletal injuries among nursing staff high due patient handling movement internationally healthcare organizations integrating technological equipment patient handling movement improve safety although evidence shows safe patient handling programs reduce work related musculoskeletal injuries nursing staff clear safe new programs patients objectives objective study explore adverse patient events associated safe patient handling programs preventive approaches veterans affairs medical centers methods study surveyed convenience sample safe patient handling program managers department veterans affairs medical centers collect data skin related fall related adverse patient events results skin fall related adverse patient events associated safe patient handling occurred medical centers skin related events included abrasions contusions pressure ulcers lacerations fall related events included sprains strains fractures concussions bleeding program managers described contextual factors adverse events ways preventing events conclusions use safe patient handling equipment pose risks patients study found organizational factors human factors technology factors associated patient adverse events findings implications nursing professionals implement safe patient handling programs ways safe staff patients published elsevier ltd
people feel prejudice toward group justify prejudice perceiving group threatening three experiments tested hypothesis prejudice causes threat perception using affective conditioning create new prejudice toward unfamiliar groups experimentally created prejudice increased threat perception experiments except threat information inconsistent conditioned affect experiment consistency affect threat information necessary order threat plausible justification prejudice mere prejudice cause perception threat absence information group finding suggests threats necessarily inherent characteristics group threat perception used way explain experience prejudice rather forming source prejudice
paper presents method compute quasi conformal parameterization qcmc multiply connected domain surface qcmc computes quasi conformal map multiply connected domain onto punctured disk associated given beltrami differential beltrami differential measures conformality distortion complex valued function supremum norm strictly less every beltrami differential gives conformal structure hence conformal module radii centers inner circles fully determined mobius transformation paper propose iterative algorithm simultaneously search conformal module optimal quasi conformal parameterization key idea minimize beltrami energy conformal module parameter domain incorporated optimal solution desired quasi conformal parameterization onto punctured disk parameterization multiply connected domain simplifies numerical computations important applications various fields computer graphics vision experiments carried synthetic data together real multiply connected riemann surfaces results show proposed method efficiently compute quasi conformal parameterizations multiply connected domains outperforms state art algorithms applications proposed parameterization technique also explored
tnf alpha long implicated progression rheumatoid arthritis however receptors tnf alpha namely tnfr tnfr mediate tnf alpha induced inflammatory responses fibroblast like synoviocytes fls elucidated present study primary fls cells isolated patients treated tnf alpha vitro exogenous tnf alpha induced expression release endogenous tnf alpha fls addition tnf alpha led gradual downregulation tnfr following treatment contrast expression tnfr markedly upregulated treatment tnf alpha moreover following tnf alpha treatment expression interleukin gradually increased time mrna levels dropped significantly investigated differential functions tnfr tnfr fls conducting sirna mediated knockdown tnf alpha autocrine inhibited greater extent tnfr silenced fls compared tnfr silenced fls silencing tnfr tnfr activated intrinsic apoptosis inhibited tnf alpha induced cytokine production fls results suggest tnfr major pro inflammatory mediator tnf alpha fls whereas tnfr upregulated response prolonged tnf alpha stimulation may act immunosuppressor fls prevention overwhelming inflammatory reactions
paper reports fabric circuit boards fcbs new type circuit boards three dimensionally deformable highly stretchable durable washable ideally wearable electronic applications fabricated using computerized knitting technologies ambient dry conditions resultant knitted fcbs exhibit outstanding electrical stability less relative resistance change strain unidirectional tensile test membrane strain three dimensional ball punch test extraordinary fatigue life loading cycles maximum strain satisfactory washing capability times best knowledge performance new fcbs far exceeded previously reported metal coated elastomeric films organic materials terms changes electrical resistance stretchability fatigue life washing capability well permeability theoretical analysis numerical simulation illustrate structural conversion knitted fabrics attributed effective mitigation strain conductive metal fibres hence outstanding mechanical electrical properties distinctive features make fcbs particularly suitable next skin electronic devices paper demonstrated application potential knitted fcbs smart protective apparel situ measurement ballistic impact
paper conduct research optimal path selection modeling road construction based particle swarm optimization algorithm relative construction companies construction project construction management particularly far reaching significance construction projects effective construction management play best effect make construction technology improve construction quality construction projects make construction safe secure time also indirectly brought considerable economic benefits overall building project path optimization task influence overall efficiency general enterprises also reflects effectiveness research starts discussion swarm optimization algorithm topology modelling build modified approach
cognitive changes occur mid life beyond linked aging menopause transition studies women suggest age menopause onset impact cognitive status later life yet little known memory changes occur transitional period postmenopausal state vinylcydohexene diepoxide vcd model simulates transitional menopause rodents depleting immature ovarian follicle reserve allowing animals retain follicle deplete ovarian tissue resulting profile similar majority perimenopausal women vehicle vcd treatment administered ovary intact adult middle aged fischer rats assess trajectory cognitive change across time normal aging aging transitional menopause via vcd induced follicular depletion well evaluate whether age onset follicular depletion plays role cognitive outcomes animals experiencing onset menopause younger age exhibited impaired spatial memory early transition follicle deplete state additionally mid post follicular depletion time points vcd induced follicular depletion amplified age effect memory overall findings suggest age onset menopause critical parameter consider evaluating learning memory across transition reproductive senescence translational perspective study illustrates age menopause onset might impact cognition menopausal women provides insight time points explore window opportunity hormone therapy menopause transition period hormone therapy critical juncture might especially efficacious attenuating age menopause related cognitive decline producing healthy brain aging profiles women retain ovaries throughout lifespan elsevier inc rights reserved
objective examine association among nursing home residents strength relationship primary care provider pcp inpatient hospital emergency room utilization method medicare administrative data beneficiaries residing nursing home july june used multivariate analyses controlling beneficiary nursing home market characteristics assess association two measurespercentage months pcp visit whether patient maintained usual source care nursing home admissionand hospital admissions visits causes ambulatory care sensitive conditions acscs results measures strength patient provider relationships associated fewer inpatient admissions visits except regularity pcp visits acsc visits discussion policy makers consider increasing strength nursing home resident pcp relationships one strategy reducing inpatient utilization
results presented largest study ever conducted item connor davidson resilience scale risc popular measure resilience examined internal consistency risc items associated mean resilience levels within sample enlisted basic trainees united states air force addition predictive validity risc total score examined real life military outcomes including attrition service mental health diagnosis risc items demonstrated strong internal consistency item level examinations scores revealed trainees reported relatively high resilience results indicated resilience measured beginning military service significant predictor attrition service obtaining mental health diagnosis within months entry implications future directions discussed
despite widespread use studies race ethnic politics exists long standing debate whether racial resentment primarily measures antiblack prejudice ideological conservatism paper attempt resolve debate examining racial resentment role shaping white opinion racialized policy issue involves federal action government redistribution resources pay play college athletics using cross sectional experimental data cooperative congressional election study amazon mechanical turk find evidence racial resentment items tap racial predispositions also whites rely predispositions forming expressing views paying college athletes specifically demonstrate racially resentful whites subtly primed think african americans likely express opposition paying college athletes compared similarly resentful whites primed think whites free market conservatism resistance changes status quo opposition expanding federal power reluctance endorse government redistributive policies possibly explain results conclude racial resentment valid measure antiblack prejudice
objective aim study evaluate relationship alexithymia aggression among men substance dependence addition wanted control effect variables depression anxiety relationship methods participants consecutively admitted substance dependent inpatients patients assessed toronto alexithymia scale buss perry aggression questionnaire beck depression inventory state trait anxiety inventory results substance dependent inpatients constituted group suffering alexithymia rates unemployed married duration education current age differ groups whereas age onset regular substance use lower group alexithymia alexithymic group higher scores aggression depression well trait state anxieties hierarchical linear regression analysis demonstrated difficulty identifying feelings dif factor alexithymia related aggression although chronic anxiety contributed relationship particularly anger hostility dimensions aggression conclusion trait dif may directly related aggression whereas state dif may way coping among chronic anxiety may indirectly related cognitive affective components aggression relevance relationships prevention treatment substance dependents deserves interest research
propose algebraization classical non classical logics based factor varieties decomposition operators particular provide new method determining whether propositional formula tautology contradiction method automatized defining term rewriting system enjoys confluence strong normalization also suggests original notion logical gate circuit propositional variables becomes logical gates logical operations implemented substitution concerning formulas quantifiers present simple algorithm based factor varieties reducing first order classical logic equational logic achieve completeness result first order classical logic without requiring additional structure
child maltreatment lead acute long term consequences important risk children identified early child healthcare chc nurses sweden position identify child maltreatment follow children parents child birth school age therefore aim describe chc nurses experiences encountering families child maltreatment identified suspected individual open interviews eight chc nurses performed analysed using qualitative content analysis findings revealed keeping child focus supporting family essential nurses family centred approach assumed benefit child interests meeting families child maltreatment identified suspected influenced nurses emotionally different ways nevertheless important keep open mind communication build honesty furthermore nurses requested professional supervision order help learn situation ahead next time knowledge chc nurses experiences may form basis development interventions aim support chc nurses professional role thereby improve support children parents future
objective autism neurodevelopmental disorder characterized difficulty verbal non verbal communication impaired social interaction restricted repetitive behavior recently introduced multigenic disorder significant epigenetic effects pathology recently epigenetic silencing retinoic acid receptor related orphan receptor alpha rora gene essential role neural tissue development shown occurred autistic children due methylation promoter region may thus explain significant part molecular pathogenesis autism therefore aimed confirm finding implementing case control experimental study population isfahan materials methods methylation status sequence gpg island encompassing cpg sites rora promoter region positions experimental study examined lymphocyte cells autistic children sodium bisulfite treatment using melting curve analysis methylation mca meth assay compared normal children also quantitative reverse transcriptase polymerase chain reaction qrt pcr analysis used estimate level mrna transcripts evaluate mca meth analysis results results study revealed methylation examined promoter regions autistic normal children melting curve studied samples comparable non methylated control results mca meth analysis also consistent qrt pcr results therefore observed significant difference levels rora transcripts blood lymphocytes autistic healthy children conclusion methylation rora promoter region may considered common epigenetic risk factor autism populations hence molecular pathogenesis autism remains unclear population investigated
bipedal locomotion active area research many decades wide ranging applications field humanoid locomotion well understanding biomechanics normal human gait inherently human gait complex non linear dynamic system usually modeled set differential equations satisfying given set constraints paper attempt made view gait perspective software engineering entire gait cycle discretized phases sub phases modeled using hybrid automaton subsequently automaton integrated bip behavior interaction priority framework thereby creating component based computational framework modeling biped locomotion correctness developed model validated verified simulation runs opensim elsevier rights reserved
management mood disorders pregnancy complex due risks associated medication use risks associated untreated depression antidepressant use pregnancy exposure unborn child currently remains unclear long term repercussions might exposure though available data reassuring hand risks mother child untreated depression pregnancy real need research nonpharmacological strategies prevention relapse mood disorders pregnant women medications reviewed number potential candidate interventions including psychotherapies exercise light box therapy lbt repetitive transcranial magnetic stimulation rtms electroconvulsive therapy ect holistic strategies nutritional herbal supplements currently lack evidence supporting use strategies prevention depressive relapse pregnancy though strategies least support use treatment major depressive episode carefully conducted research using one strategies women want discontinue antidepressants pregnancy sorely needed
path minimum problem preprocess tree weighted nodes given arbitrary path node smallest weight along path located design novel succinct indices problem indexing model weights nodes read accessed ranks nodes preorder traversal sequence input tree presentan index within bits additional space supports queries time accesses weights nodes integer index within bits additional space supports queries time accesses weights nodes inverse ackermann function indices give first succinct data structures path minimum problem following approach also develop succinct data structures semigroup path sum queries query asks sum weights along given query path one data structures requires sigma sigma bits space alpha query time sigma size semigroup path reporting problem queries ask nodes along query path whose weights within two sided query range using succinct indices path minimum queries achieve three different time space tradeoffs path reporting designing word data structure epsilon occ epsilon query time word data structure occ query time word data structure occ query time occ number nodes reported arbitrary constant tradeoffs match state art two dimensional orthogonal range reporting queries chan treated special case path reporting queries number distinct weights much smaller improve query time space cost three results
nexus reproductive health population development subject sexuality generated extensive discourse past two decades paper review africa sexuality studies published aim synthesizing available evidence suggesting new research agenda post review findings showed previous studies covered five components sexuality practices partners pleasure pressure pain procreation power different extents risky sexual behaviour prevalent adolescence till older ages literature pleasure pain procreation power reflect complex diversity driven traditional norms gender roles attitudes across continent knowledge gaps highlighted new agenda suggested sexuality research
purpose study identify key psychosocial characteristics hiv infected women exhibit different levels art adherence risk behaviors analyzed baseline data predominately african american hiv infected women participating behavioral clinical trial women categorized high low groups based levels adherence risky behaviors significant interaction effect internal motivation adherence women high risk poor health transmitting hiv low adherence high risk group lowest levels internal motivation also reported difficult life circumstances gender roles caretaking reliance men economic support may promote external versus internal motivation well riskier behaviors group highest levels internal motivation found high adherence high risk behaviors group highly knowledgeable hiv lowest compared others group seems tolerate risky behaviors given high level adherence adherence risk reduction behaviors key individual public health motivation risk compensation addressed providing interventions women living hiv
paper provides analysis electrical circuits described fractional difierential equation caputo type order considered gamma laplace transform fractional derivative used keep dimensionality physical quantities auxiliary parameter sigma introduced characterizing existence fractional components system relationship gamma sigma reported response obtained fractional circuits exhibits characteristic behaviors cap resistor memcapacitor memristor well charge voltage memcapacitive systems current voltage memristive systems relationship ohm law faraday laws charge stored capacitor induction reported illustrative examples presented
aim women anorexia often perceived negatively example manipulative deceitful wider society treatment providers context important practitioners understand experience living illness little empirical research focused everyday phenomenology anorexia study aimed expand limited literature giving voice lived experience women anorexia method purposive sample women formal diagnosis result nhs treatment one long behavioural history dietary restriction received private treatment saw recovered recovery anorexia nervosa participated semi structured interviews women asked history eating disorder understandings cause experiences seeking help treatment results data analysed thematic analysis three themes identified shame solitude salvation taken together describe dual role anorexia nervosa problem solution cyclical nature sufferers behaviours feelings way anorexia nervosa form distress make sufferers feel better well worse conclusions light shed ambivalence recovery resistance treatment frequently experienced sufferers implications findings work eating disorders clients discussed
paper indirect combustion noise generated acceleration entropy perturbations supercritical nozzle investigated nonlinear regime low frequency limit quasi static hypothesis work completes study huet giauque journal fluid mechanics nonlinear noise generation nozzle flows without shock particularly focuses shocked flow regimes based analytical model marble candel compact nozzles journal sound vibration initially developed excitations linear regime rederived nonlinear perturbations full nonlinear analytical solutions provided absence shock well second order analytical expressions shock present diffuser analytical evaluation shock displacement inside nozzle caused forcing proposed maximum possible forcings avoid unchoke choke discussed accuracy second order model nonlinear contributions generated waves addressed model found accurate generated entropy wave negligible nonlinear contributions nonlinearities visible still limited downstream acoustic wave large inlet mach numbers analytical developments validated thanks comparisons numerical simulations elsevier ltd rights reserved
purpose manuscript describe collaborative research initiative explore role hydration kidney health understanding effects hydration health disease surprisingly limited particularly consider vital role hydration basic human physiology recent initiatives research outcomes challenged global medical community expand knowledge hydration including differences water sugared beverages consumables identification potential mechanisms contributing benefits hydration stimulated global nephrology community advance research regarding hydration kidney health hydration kidney health focus research several research centers rapidly expanding world literature knowledge international society nephrology collaborated danone nutricia research promote development kidney research initiatives focus role hydration kidney health global translation new information initiative supports use existing data different regions countries expand dialogue among experts field hydration health increase scientific interaction productivity ultimate goal improving kidney health author published karger basel
introduction colloid cysts histologically benign present broad spectrum symptoms systematic review literature reveal patient centered data headache disability quality life qol patients methods retrospective cohort study colloid cyst patients colloid cyst survival group completed survey included demographic data clinical data modified qol survey sfv headache disability inventory index hdi results using multivariable linear regressions confirmed physical pcs mental mcs components significantly increased surgery group adjustment various baseline characteristics self reported headache disability significantly decreased surgery adjusted baseline characteristics finally patients incidental diagnosis colloid cyst reported similar benefits surgery pcs mcs hdi conclusion results suggest colloid cyst patients underwent surgical resection self report better qol less headache disability compared patients undergo surgery future prospective studies baseline measures qol indicated confirm findings
interpersonal space nonverbal indicator affiliation closeness study investigated effects oxytocin neuropeptide known social role humans interpersonal space double blind placebo controlled study measured effect intranasal personal distance preferences different familiar friend unfamiliar stranger protagonists behavioral results showed participants preferred closer friend stranger intranasal associated overall distancing effect effect significant stranger friend imaging results showed interactions treatment placebo protagonist friend stranger regions mediate social behavior including dorsomedial prefrontal cortex dmpfc region associated mentalizing system specifically increased activity dmpfc friend approached participants stranger approached results indicate effect interpersonal space greatly depends participant relationship protagonist supports social salience theory according increases salience social cues depending context elsevier ltd rights reserved
division summation sigma digital control successfully applied single phase bidirectional inverter filter coverwide inductance variation achieve precise inverter current tracking however high frequency ripple current injection grid avoided lcl filter therefore required since typically exist grid voltage harmonics injected grid current contain harmonic components due effect lcl filter capacitor paper presents extended application sigma digital control associated filter capacitor current compensation reduce injected grid current harmonics control laws inverter sigma digital control compensation approach derived detail reduction grid current harmonics analyzed proposed approaches phase margin output impedance inverter grid impedance higher degrees low high frequencies inverter achieve high harmonic voltage rejection ratio harmonic relatively suitable weak grid connection experimental results measured single phase bidirectional inverter verified feasible application sigma digital control proposed compensation
recent years seen increasing number scientists employing data parallel computing frameworks hadoop order run data intensive applications research data grouping aware data placement hadoop become increasingly popular however observe many data grouping aware data placement schemes static without taking mapreduce job execution frequency consideration data placements scheme lead severe performance degradation way potential efficiency optimal data distribution executing mapreduce jobs executed frequency paper propose new data grouping aware dynamic dgad data placement method based job execution frequency firstly build job access correlation relation model among data blocks according relationships provided records historical data block access use clustering algorithm divide data blocks clusters according job access correlation relation model among data blocks propose data placement algorithm based data block clusters order put correlated data blocks within cluster different nodes finally series experiments carried order verify method proposed paper experimental results show proposed method effectively deal mass data obviously improve execution efficiency mapreduce elsevier rights reserved
hazard assessment chemical contaminants often relies short term partial life cycle ecotoxicological tests impact low dose throughout entire life cycle species across multiple generations neglected study aimed identifying individual population level consequences chronic water contamination environmental concentrations three organic micropollutants ibuprofen bisphenol benzo pyrene aedes aegypti mosquito populations experimental conditions life history assays spanning full life cycle exposed individuals progeny associated population dynamics modelling evidenced life history traits alterations unexposed progenies individuals chronically exposed ibuprofen benzo pyrene progeny individuals exposed ibuprofen showed accelerated development progeny individuals exposed benzo pyrene showed developmental acceleration associated increase mortality rate development life history changes due pollutants exposure resulted relatively shallow increase aegypti asymptotic population growth rate multigenerational exposure six generations revealed evolution population response ibuprofen benzo pyrene across generations leading loss previously identified transgenerational effects emergence tolerance bioinsecticide bacillus turingiensis israelensis bti study shed light short long term impact environmentally relevant doses ibuprofen benzo pyrene aegypti life history traits insecticide tolerance raising unprecedented perspectives influence surface water pollution vector control strategies overall approach highlights importance considering entire life cycle organisms necessity assess transgenerational effects pollutants ecotoxicological studies ecological risk assessment finally multi generational study gives new insight influence surface water pollution microevolutionary processes elsevier ltd rights reserved
backgroundinformation long term follow childhood onset anorexia nervosa scarce study investigated long term years course outcome prognostic factors hospitalized childhood onset anorexia nervosa restricting type anr methodsforty one anr girls admitted single regional center participated median age first admission years range years longitudinal clinical course retrospectively determined median follow period years range years analyzed physical psychological social variables predict partial remission full remission resultsthe completion rate follow years high final evaluation distribution prognosis follows non remission cumulative ratio increased first years gradually reached plateau around years years onset one patient eventually achieved one patient died seven patients rehospitalized two died due suicide entire follow multivariate analysis family disorders problems rating score significant predictor conclusionsthis study included hospitalized anr children aged years youngest cohort ever reported long term prognosis generally favorable mortality rate careful long term follow years needed evaluate outcome childhood onset anr family therapy important high risk patients family disorders problems
objective evaluate effects catalase cat superoxide dismutase sod glutathione gsh system range severity coronary artery lesions patients abnormal glucose metabolism methods study included patients abnormal glucose metabolism levels fasting blood lipids blood glucose cat sod gsh glutathione reductase glutathione peroxidase gsh measured patients coronarography performed degree lesions coronary artery quantitatively analyzed using gensini scoring system results patients impaired glucose regulation diabetes number coronary artery branches stenosis gensini scores inversely correlated plasma levels cat sod gsh gshpx patients grouped according gensini scores scores increased levels cat sod gsh gsh gradually decreased logistic gradual regression analysis showed gsh cat independent risk factors associated coronary artery lesions three branches conclusions decreased plasma levels cat sod gsh gsh inversely correlated least extent extent coronary artery lesions particularly gsh cat independent risk factors associated coronary artery lesions involving three branches suggests long term hyperglycemia leads enhancement oxidative stress
patient reported outcomes pros europe developed rheumatoid arthritis impact disease raid important assess patients quality life interpretation may culture dependent evaluate potential utility raid multiethnic asian rheumatoid arthritis patients cross sectional study english speaking patients singapore tertiary center validity raid scored higher score indicating worse status assessed spearman correlation patient global assessment pga das short form consistency assessed cronbach alpha test retest reliability intra class correlation coefficient icc days feasibility assessed missing data eighty two patients analyzed median age years disease duration years women chinese although moderately active median das raid score low median patients raid score raid strongly correlated pga moderately outcomes das physical mental consistency high cronbach alpha test retest reliability excellent icc confidence interval feasibility good patients missing data despite considerable floor effects raid appeared valid practical pro assess impact asia multiethnic asian patients may underestimate impact disease compared european patients
fascinating complex dynamic part organism human brain shaped many interacting factors neurobiological including sex hormones environmental origin also sociocultural nature social roles gender one factors neurological neurodevelopmental neuropsychiatric psychosomatic disorders characterized impairments visual social cognition primarily body language reading face perception skewed sex ratio females males affected differently terms clinical picture prevalence severity social brain sex specific still open question long time many reasons sex differences overlooked entirely ignored neuroscience biomedical research paucity neuroimaging work examining sex differences social brain however pattern experimental behavioral data healthy typically developing individuals patients deficient social cognition beyond simple interpretation contrary popular wisdom females always proficient understanding social signals social abilities may particularly affected disease clarification neurobiological sex sociocultural gender affect social brain would provide novel insights understanding gender specific vulnerability neuropsychiatric disorders interaction far beyond simplicity although sex differences represent rather delicate topic underestimation exaggeration possible effects retards progress field wiley periodicals inc
problem finding optimal configuration automated smart power distribution systems topology hard combinatorial optimization problem becomes complex time varying nature loads taken account paper systematic approach proposed determine optimal long term reconfiguration schedule solve optimization problem novel adaptive fuzzy based parallel genetic algorithm proposed employs concept parallel computing identifying optimal configuration network integration fuzzy logic proposed method enhances efficiency parallel adaptively modifying migration rates among different processors optimization process computationally efficient graph encoding method based dandelion coding strategy developed automatically generates radial topologies prevents construction infeasible radial networks optimization process order consider dynamic behavior load reduce load condition scenarios year study fuzzy mean clustering method utilized finally performance proposed method demonstrated bus distribution network compared conventional single conventional parallel
autism spectrum disorder asd neurodevelopmental disorder whose symptoms include social communication deficits repetitive rigid behaviours broad autism phenotype bap includes milder subclinical personality language characteristics explored relationship bap features empathy skills friendships emerging adults without biological relative asd found emerging adults groups bap features less interest shorter duration friendships relationship mediated empathy weak empathy skills experienced negative friendship outcomes mixed methods study sheds light relational implications exhibiting bap features importance non normative life events friendships elsevier ltd rights reserved
shape alignment estimation occlusion one challenging tasks computer vision field previous works treat occlusion noises part models usually lead low accuracy inefficiencies paper proposes efficient accurate regression based algorithm face alignment framework local global regressions iteratively used train series random forests cascaded manner training testing process step consists two layers first layer set highly discriminative local features extracted local regions according locality principle regression forests trained facial landmark independently using local features leaf node regression tree encoded histogram statistic method final shape estimated linear regression matrix second layer proposed global features generated use features train random fern keep global shape constraints experiments show method high speed slightly lower accuracy state art methods occlusion condition order gain higher accuracy use multi random shape initialization may slightly reduce calculation efficiency trade
paper documents utility online tool rainwater harvesting demand simulation forwarded url http gettanked orgi categorizes performance variability respect koppen geiger climatic classifications australian continent novel tool dynamically calculates irrigation evaporative cooling demands addition particular per diem allocation potable water analysis may either finite storage tank specified capacity drawn water mains present paper focused design secure grid rainwater harvesting systems rwhs nominal consumption target per diem per capita must reduced varying degrees depending locality higher demand met sufficient catchment capacity provided regular tanker deliveries readily available alternatively demand restrictions tabulated guidance avoid running dry within constraints nominal capacity storage catchment defining sustainable load per diem slpd worst case epoch break point grid security slpd varies among temperate maritime climate stations lid desert climate stations supporting line operating manual includes tabulations demand evaporative cooling irrigation together sustainable yield rainwater harvest system locations throughout australia dynamics non potable demands resolved using gettanked design tool particular dwelling workplace indoor potable water demand must disaggregated irrigation pool evaporation evaporative cooling order fully exploit gettanked tool elsevier rights reserved
like immune cells natural killer cells show impaired effector functions microenvironment tumors little known underlying mechanisms since lactate acidosis hallmark malignant tissue shown contribute suppression effective antitumor immune responses investigated impact tissue lactate concentration cell functions aggressive model endogenously arising cell lymphoma progressive loss ifn gamma production cells observed development disease could ascribed decreased values lactate accumulation microenvironment growing tumors interestingly ifn gamma expression lymphoma derived cells could restored transfer cells normal micromilieu likewise systemic alkalization oral delivery bicarbonate lymphoma developing mice capable enhancing ifn gamma expression cells increasing cell numbers lymphoid organs tumors growing contrast cell cytotoxicity dampened vivo tumor dependent mechanisms seemed different lactate acidosis could restored normal milieu importantly alkalization concomitant ifn gamma upregulation cells sufficient significantly delay tumor growth without immunotherapy effect strictly dependent cells
marfan syndrome mfs rare autosomal dominant multisystem disorder presenting skeletal ocular skin cardiovascular symptoms significant clinical overlap systemic connective tissue diseases including loeys dietz syndrome lds shprintzen goldberg syndrome sgs mass phenotype documented mfs lds cardiovascular manifestations account major cause patient morbidity mortality rendering main target therapeutic intervention past decades gene identification studies confidently linked aforementioned syndromes well nonsyndromic aneurysmal disease genetic defects proteins related transforming growth factor tgf beta pathway greatly expanding knowledge disease mechanisms providing novel therapeutic targets result focus developing pharmacological treatment strategies shifting hemodynamic stress management tgf beta antagonism review discuss insights gained molecular biology mfs related disorders past years wiley periodicals inc
redirection techniques allow users explore large virtual environments foot remaining within limited physical space however research primarily focused redirection manipulation visuals used represent virtual environment describe within subjects study exploring participants ability detect differences real virtual rotations influenced addition sound spatially aligned virtual source results revealed similar detection thresholds conditions involving moving audio static audio audio may viewed indication visual dominance scenarios one used current study
purpose purpose paper identify impact human resource development hrd engineering procurement construction epc project success human resource competency hrc job performance interrelationship among paper also investigates impact epc project factors factors affecting hrd including internal factors external factors epc project implementation design methodology approach structural equation modeling sem spss amos software used test nine proposed hypotheses respondents comprised participants involved epc projects throughout vietnam findings results show hrd positively affects hrc hrd influenced influenced hrc positively impacts directly impacts originality value study indicates development competent human resources epc project implementation plays considerable role epc findings also give project professionals tool improving hrd hrc increase likelihood
computer aided ray microtomography increasingly popular method investigate structure materials continuing improvements technique resulting increasingly larger data sets analysis data sets generally involves executing static workflow multiple samples generally performed manually researchers executing processes requires significant time investment workflow able automate activities user would useful work developed automated workflow analysis microtomography scanned bread dough data sets averaging size comparing automated workflow manual workflow indicates significant amount time spent case bread dough user interactions manual method workflows return similar results porosity pore frequency distribution finally implementing automated workflow users save time would required manually execute workflow time spent productive tasks lay description technological advances ray scanning techniques resulted larger complex microtomographic datasets processing datasets time consuming oftentimes repetitive task datasets similar materials tend similar characteristics better way analyze datasets research investigated using computer programming languages instead researchers automatically perform tasks involved analysis microtomographic datasets ten scanned bread dough samples results highlighted benefits using computers automate analysis process demonstrating nearly time required due researchers interacting analysis programs analysis quantitative data provided automated workflow nearly identical results found researchers research highlights benefits using automated computer processing analysis microtomographic datasets would allow researchers spend efforts elsewhere
objective lack safety data supporting use hormone therapy women breast cancer complained genitourinary syndrome menopause gsm objective test efficacy two non hormonal therapies vaginal dryness methods randomized trial women breast cancer treated tamoxifen complained vaginal dryness volunteers answered two questionnaires evaluate sexual function female sexual function index fsfi customized gsm questionnaire women randomized two groups polyacrylic acid group lubricant group using either one treatments days invited answer questionnaires results improvement fsfi treatments polyacrylic acid group showed decrease sexual dysfunction lubricant group showed decrease conclusions results study showed treatments improved sexual function however polyacrylic acid superior lubricant treating sexual dysfunction
emotion dysregulation core characteristic patients borderline personality disorder bpd often attributed imbalance fronto limbic network function hyperarousal amygdala especially response negative affective stimuli results affective interference cognitive processing executive functions clinical consequences include impulsive aggression suicidal self injurious behaviors characterize bpd dysfunctional interactions amygdala network targets well characterized cognitive task performance using psycho physiological interaction analysis ppi mapped network profiles amygdala interaction key regulatory regions task modified use negative positive neutral ekman faces targets fifty six female subjects bpd healthy controls completed affectively valenced task fmri scanning negative affective condition amygdala exerted greater modulation targets bpd compared subjects ofc dacc parietal cortex basal ganglia dipfc across spectrum affective contrasts hypermodulation bpd subjects observed following ordering negative neutral positive contrast amygdala seed exerted modulatory effects specific target regions important processing response inhibition motor impulsiveness vulnerability bpd subjects affective interference impulse control may due specific network dysfunction related amygdala hyper arousal effects prefrontal regulatory regions ofc dacc elsevier ltd rights reserved
aeuro cent elastography parameters second nact cycle showed best diagnostic performances aeuro cent swe yielded similar diagnostic performances predicting favourable responses aeuro cent swe performed better predicting pathological resistance nact aeuro cent discrepant results may due breast thickness lesion depth
background studies demography public health acknowledged role ethnic differences influence ethnicity youth sexual behaviour nigeria received little attention important know cultural norms gender roles vary ethnicity may promote prevent risky behaviour information could provide insights previously undetected sexual behaviour multi ethnic situations methods nigeria demographic health surveys ndhs pooled examine relationship ethnicity youth sexual reproductive health proxied age sexual debut multiple sexual partners msp condom use last sexual activity among females males reported sexually active four weeks preceding survey multivariate analysis using cox proportional hazard regression model used determine risk factors early sexual activity among young people logistic regression used predict condom use last sexual activity msp results median age first sexual activity females males male youths used condoms last sexual activity compared among females higher number males multiple sexual partners compared females females elevated risks first sex higher among hausa fulanis aged elevated risk first sex higher among yoruba males conclusion study provides evidence order promote protective sexual behaviours among youth nigeria social cultural gender specific tactics put place prevention hiv stis
objective language barriers commonly encountered prehospital setting paucity research prehospital providers address language discordance sought identify communication strategies limitations strategies used emergency medical services ems providers confronted language barriers variety linguistic cultural contexts methods ems providers queried regarding communication strategies overcome language barriers part international multi site sequential explanatory qualitative predominant mixed methods study prehospital language barriers survey ems telecommunicators administered dispatch centers new mexico united states western cape south africa semi structured qualitative interviews ems field providers conducted agencies respond calls participating dispatch centers survey data included quantitative data demographics communication strategies used overcome language barriers well qualitative free text responses limitations strategies interviews elicited narratives encounters language discordant patients strategies used communicate data surveys interviews integrated point analysis results telecommunicators overall response rate purposive sample field providers participated study characteristics participants varied countries agencies consistent variations participating agencies hiring training practices telecommunicators identified party telephonic interpreter services single effective strategy available also described time delays frustration interpreter communications leads preferentially try strategies field providers reported using similar strategies relying heavily bystanders multilingual coworkers nonverbal communication prehospital providers described significant limitations strategies including time delays breaches patient confidentiality inaccurate interpretation participants suggested various resources improve communication language discordant patients conclusions prehospital providers rely upon similar informal strategies overcoming language barriers across variety locations provider types linguistic cultural contexts
purpose review micrornas mirnas regulatory rnas act posttranscriptional repressors binding untranslated region target genes implicated diverse biologic pathologic processes emerging important players kidney health disease review latest literature exciting rapidly evolving field recent findings studies conditional dicer knockout mice revealed critical roles mirnas orchestrating kidney development maintaining structural functional integrity renal collecting system glomerular barrier expression profiling provided reasonably clear picture mirnas present normal kidney pointed individual mirnas may serve special functional roles therein specific mirnas implicated pathways linked cystic kidney disease mir wilms tumor mir several mirnas upregulated transforming growth factor beta models diabetic nephropathy promote matrix deposition mir mir epithelial mesenchymal transition mir mir whereas preliminary findings suggest others might serve protective roles mir mirnas recently identified urinary exosomes could potentially serve disease biomarkers summary nephrology midst mirna revolution promises incredible advances understanding genetic regulatory pathways underlying kidney disease new avenues treatment
paper proposes new distributed architecture supervised classification large volumes earth observation data cloud computing environment architecture supports distributed execution network communication fault tolerance transparent way user architecture composed three abstraction layers support definition implementation applications researchers different scientific investigation fields implementation architecture also discussed software prototype available online runs machine learning routines implemented cloud using waikato environment knowledge analysis weka popular free software licensed gnu general public license used validation performance issues addressed experimental analysis two supervised classifiers available weka used random forest support vector machines paper describes include classification methods available software prototype
fully three dimensional computational fluid dynamic simulations detailed combustion chemistry turbulent jet ignition system installed rapid compression machine presented turbulent jet ignition system prechamber initiated combustion system intended allow lean burn combustion spark ignition internal combustion engines presented configuration turbulent jet ignition prechamber volume volume main combustion chamber rapid compression machine separated main chamber nozzle containing single orifice four simulations orifice diameters respectively presented order demonstrate effect orifice diameter combustion behavior turbulent jet ignition process data generated simulations shown including combustion chamber pressures temperature fields jet velocities mass fraction burn durations combustion pressure trace jet velocity field data five distinct phases turbulent jet ignition process identified phases called compression phase prechamber combustion initiation phase cold jet phase hot jet phase flow reversal phase four simulations show orifice diameter provides fastest ignition fastest overall combustion reflected mass fraction burn duration data generated meanwhile simulation orifice diameter produces highest jet velocity shortest delay spark exit jet hot gases main chamber produces slower burn duration simulation larger orifice diameter simulations orifice diameters demonstrate combustion speed reduced orifice diameter increases finally discussion given examines implications results generated regard implementation turbulent jet ignition system internal combustion engine
epidemiological evidence indicates thyroid stimulating hormone tsh positively correlated abnormal glucose levels previously reported tsh direct effects gluconeogenesis however underlying molecular mechanism remains unclear study observed increased fasting blood glucose glucose production mouse model subclinical hypothyroidism elevated tsh levels tsh acts via classical camp pka pathway crtc regulates glucose homeostasis thus explore whether crtc involved process tsh induced gluconeogenesis show tsh increases crtc expression via tshr camp pka pathway turn upregulates hepatic gluconeogenic genes furthermore tsh stimulates crtc dephosphorylation upregulates pcreb ser hepg cells silencing crtc creb decreases effect tsh pepck luciferase rate limiting enzyme gluconeogenesis finally deletion tshr reduces levels crtc creb complex mouse livers study demonstrates tsh activates crtc via tshr camp pka pathway leading formation crtc creb complex increases hepatic gluconeogenesis elsevier rights reserved
background probiotics observed positively influence host health date data ability probiotics modify gut microbiota composition exist aims evaluate ability lactobacillus kefiri lkf dsm lkef colonize intestinal environment healthy subjects modify gut microbiota composition methods twenty italian healthy volunteers randomized pre prandial post prandial groups changes gut microbiota composition detected using next generation sequencing technology ion torrent personal genome machine results kefiri recovered feces volunteers one month probiotic administration detected three subjects belonging pre prandial group two subjects belonging post prandial group one month end probiotic consumption one month probiotic oral intake observed reduction bilophila butyricicomonas flavonifractor oscillibacter prevotella interestingly end probiotic administration bacteroides barnesiella butyricicomonas clostridium haemophilus oscillibacter salmonella streptococcus subdoligranolum veillonella significantly reduced compared baseline samples conclusion kefiri lkf showed strong ability modulate gut microbiota composition leading significant reduction several bacterial genera directly involved onset pro inflammatory response gastrointestinal diseases authors published elsevier ltd behalf editrice gastroenterologica italiana open access article license http creativecommons org licenses bync
purpose primary objective use isotemporal substitution models estimate whether replacing time spent sedentary video games svgs active outdoor play aop active video games avgs would associated changes youth mental health methods representative sample canadian youth grades studied exposure variables average hours day spent playing avgs svgs aop outcomes consisted negative internalizing mental health indicator emotional problems positive internalizing mental health indicator life satisfaction positive externalizing mental health indicator prosocial behavior isotemporal substitution models estimated extent replacing time spent svgs aop equivalent amount time avgs mental health indicators results replacing hour day svgs hour day avgs associated confidence interval reduced probability high emotional problems increased probability high life satisfaction increased probability high prosocial behavior replacing hour day aop hour day avgs associated increased probability high emotional problems reduced probability high life satisfaction reduced probability high prosocial behavior conclusions replacing svgs avgs associated preferable mental health indicators conversely replacing aop avgs associated deleterious mental health indicators society adolescent health medicine rights reserved
background human leukocyte antigen hla mismatch characteristic feature post orthotopic liver transplantation olt hepatitis investigate importance donor hla restricted immune cells post olt hepatitis recurrence analyzed frequency donor chimerism clinical course post olt hepatitis material methods analyzed peripheral blood chimerism hcv reinfected patients post hla mismatched olt patients divided groups olt chronic hepatitis chc group exhibiting active hepatitis recurrence olt persistently normal alt pnalt group without active hepatitis chimerism analyzed flow cytometry using donor specific anti hla antibodies peripheral blood mononuclear cells days olt kidney lung transplant recipients also analyzed comparison immune cells donor liver might contribute post olt chimerism characteristics perfusates donor livers analyzed defined results donor derived cells frequently observed liver lung transplant recipients frequency donor derived cells cell subset significantly higher peripheral blood olt chc group olt pnalt group cells however predominant subset perfusates indicating inflow donor derived cells alone cause chimerism conclusions chimerism cells frequent liver transplant patients early recurrence hepatitis propose monitoring early chimerism could facilitate early detection chronic hepatitis recurrence although need cases investigate
intelligent smart environments usually developed various indoor applications capable supporting independent living seniors handicapped people taking account recent achievements ambient intelligence wearable technologies wireless sensor networks especially focused area environmental monitoring need intelligent support various human activities also outdoor environment evident solutions focused intelligent support human activities natural outdoor environment still rarely developed published way useful outdoor applications may lead exploitation large scale ambient intelligence approaches respecting distributed character outdoor applications also cloud based solutions seem naturally utilizable purpose paper reviewing several existing solutions related areas discuss possibilities cloud based solutions intelligent environments oriented human activities support outdoor spaces approach illustrated using scenario based explanation
using simplified high frequency small signal equivalent circuit model bsim mosfet fully differential two stage folded cascode cmos operational amplifier analyzed obtain small signal voltage transfer function result expressions gain five zero frequencies five pole frequencies unity gain frequency phase margin derived amp design using design equations analysis result verified comparison spice simulations high speed amp low power amp designed cmos process
article apply result equivalent errors contouring control problem five degree freedom robot manipulators proposed technique fuzzy proportional integral derivative pid robust extended kalman filter employed stabilize dynamic equivalent errors robot manipulators shape membership functions rules fuzzy pid controller tuned following operating conditions make control performance improve significantly desired path terms position end effector robot manipulators described generalized coordinates defined dynamic equivalent simulation experimental results demonstrate excellent performance proposed technique
lymphoedema breast cancer surgery chronic condition lymphoedema treatment consists information advice compression physical exercise skin care manual lymph drainage little known patients experience adapt respond lymphoedema treatment thus purpose study investigate describe women perceptions lymphoedema treatment breast cancer surgery sixteen women breast cancer related lymphoedema recruited four hospitals two rehabilitation clinics participated study semi structured interviews conducted analysed using phenomenographic method five qualitatively different categories description could identified uncertainty disappointment guilt shame safety autonomy categories could described based two dimensional structure patients role internal external locus control understanding lymphoedema chronic disease burden study provided deeper understanding different ways patients perceive respond lymphoedema treatment present findings enable lymphoedema therapist individualise treatment counselling based patient approach patient role ability take responsibility treatment acceptance lymphoedema chronic disease
paper propose three party multi party quantum key agreement protocols single photons polarization spatial mode degrees freedom based defined collective unitary operations participants agree secure shared key encoding sub secret keys particles moreover security protocols discussed comprehensively showed presented protocols defend outside attacks participant attacks efficiency analysis also shows two protocols achieve high qubit efficiency besides protocols feasible since preparation themeasurement singlephoton state polarization spatial mode degrees freedom available current quantum techniques
process measurements vital importance monitoring control industrial plants consider offshore oil production platforms wells require gas lift technology yield oil production low pressure oil reservoirs become unstable conditions undesirable phenomenon usually called slugging flow identified oscillatory behavior downhole pressure measurement given importance measurement unreliability related sensor work aims designing data driven soft sensors downhole pressure estimation two contexts one speeding first principle model simulation vertical riser model another estimating downhole pressure using real world data oil well petrobras based topside platform measurements tasks tackled employing echo state networks esn efficient technique training recurrent neural networks show single esn capable robustly modeling slugging flow behavior steady state based square wave input signal representing production choke opening vertical riser besides compare performance standard network performance multiple timescale hierarchical architecture second task show latter architecture performs better modeling large irregular transients commonly occurring small oscillations elsevier ltd rights reserved
wireless domestic applications involving high data rates required work millimeter wave band signal propagation frequency range affected walls oxygen absorption limits communication distances meters one room radio coverage extended rooms optical links performances photonic systems dependent optoelectronic devices electrical driving receiver circuits paper radio fiber rof links based intensity modulation direct detection technique investigated transmission broadband ofdm signal direct external modulations exploited analyze system performances according ultra wideband uwb millimeter band standard avoid component tolerances high frequencies intermediate frequency modulation optical transducers chosen optoelectronic optical components rof links modeled equivalent electrical circuits consideration noise nonlinearities models validated system simulation error vector magnitude evaluation measurement setup according uwb centimeter band standard
introduction mesenchymal stromal cells mscs changed management crohn fistula remains controversial aim study provide overview efficacy optimum state mscs treatment crohn fistula studies reporting mscs treatment crohn fistula searched included fixed effects model used assess efficacy mscs outcomes healing recurrence used evaluate best states mscs intervention fourteen articles enrolled pooled analysis showed mscs significant efficacy compared treatments risk difference notably mscs treatment group crohn disease activity index cdai baseline group higher healing rate clinical response change cdai points compared cdai baseline candidate evaluating effectiveness mscs application crohn fistula
coming big data era data processing large scale comes new challenge however string matching still plays important role network security information retrieval fields large size pattern set overhead memory access memory time improving string matching algorithm adapt large scale tasks desirable meaningful paper present implement parallel algorithm multiple string matching based multi core platform addition work focuses partition pattern set using genetic algorithm internal relation patterns reduce memory overhead execution performance compared classical ones experiments high low hit rate data demonstrate performance algorithm enhances average general besides proposed algorithm reduces memory cost average
educators periodically encounter need report suspicion child abuse neglect studies show school professionals recognize half maltreated children uncertainty reporting policies practices procedures experience may difficult educator report made precipitates variety emotions need support many educators often encounter challenges barriers reporting procedures within school settings educators lack support educational institution may fail report suspicion child maltreatment article explores child maltreatment reporting practices point view educator school setting proposes strategies address reporting practices effectively appropriate intervention services required meet needs children suspicion abuse neglect built model shape training policies procedures therefore strategies cultivate immediately legally responsive environments imperative educational setting begin reduce number maltreated child cases unreported
cross sectional neuroimaging studies non depressed individuals demonstrated inverse relationship daylight minutes cerebral serotonin transporter relationship modified serotonin transporter linked polymorphic region short allele carrier status present data first longitudinal investigation seasonal serotonin transporter fluctuations patients seasonal affective disorder healthy individuals eighty dasb positron emission tomography scans conducted quantify cerebral serotonin transporter binding healthy controls low seasonality scores patients diagnosed seasonal affective disorder scanned summer winter investigate differences cerebral serotonin transporter binding across groups across seasons two groups similar cerebral serotonin transporter binding summer symptomatic phase winter patients seasonal affective disorder higher serotonin transporter healthy control subjects compared healthy controls patients seasonal affective disorder changed serotonin transporter significantly less summer winter change serotonin transporter sex genotype dependent patients seasonal affective disorder seasonal change serotonin transporter binding positively associated change depressive symptom severity indexed hamilton rating scale depression seasonal affective disorder version scores findings suggest development depressive symptoms winter associated failure downregulate serotonin transporter levels appropriately exposure environmental stress winter especially individuals high predisposition affective disorders
prior research shows people feel authentic express research examined people different cultures make inferences target person authenticity based information person self expression cultural fit hypothesis proposes acts self expression enhance perceptions authenticity congruent culturally prevalent self expression norms experiment germans chinese reading scenarios making inferences hypothetical person found authenticity judgments highest target person self expression matched culturally valued self expression style expressing likes dislikes germany expressing likes dislikes china moreover found interactive effect self expression culture downstream effects information processing case counter cultural self expression practices participants likely seek information would compensate cultural incongruence
various model selection methods applied seek sparse subsets covariates explain response interest bioinformatics methods often offer helpful predictive performances selections covariates may much less trustworthy indeed number covariates large selections highly unstable even slight change data casts serious doubt reproducibility identified variables sound scientific understanding regression relationship methods need developed find important covariates higher chance confirmed future studies method based variable selection deviation proposed evaluated work
leptomeningeal disease lmd represents disseminated intracranial metastatic disease requires early detection initiation therapy patients lmd typically present variety neurologic problems including ocular disturbances however little reported lmd presenting exclusively ocular related disturbances absence central nervous system cns dysfunction goal describe workup ocular disturbances setting known cancer diagnosis retrospective case study utilizing prospectively collected database tertiary cancer care center patients diagnosis lmd main outcome descriptive analysis ocular findings primary admitting service without formal ophthalmology exam workup lmd patients demonstrated ocular disturbances without cns manifestations findings demonstrate ocular disturbances detected primary admitting services formal consultation ophthalmology resulted detection remaining cases common findings cranial nerve deficits papilledema optic disc retinal infiltration tumor findings supported work cns disease therefore appropriate refer cancer patients visual complaints findings exam ophthalmology evaluate evidence suggestive lmd may support work elsevier ltd rights reserved
paper describes development pedestrian microsimulation model developed based agent based modeling approach effectively accounts pedestrian intelligence heterogeneity model focuses producing accurate trajectories pedestrian interactions behavior rules control pedestrian interactions extracted detailed pedestrian behavior study conducted vancouver calibration model parameters performed using genetic algorithm aimed minimizing error simulated trajectories real trajectories obtained means computer vision validation results conducted using two different data sets average errors simulated actual trajectories two data sets respectively average speed errors results also showed model capable predicting correct collision avoidance strategy validation cases investigated
microaggression concept recently galvanized public discussion spread numerous college campuses businesses argue microaggression research program mrp rests five core premises namely microaggressions operationalized sufficient clarity consensus afford rigorous scientific investigation interpreted negatively minority group members reflect implicitly prejudicial implicitly aggressive motives validly assessed using respondents subjective reports exert adverse impact recipients mental health review literature reveals negligible support five suppositions broadly mrp marked absence connectivity key domains psychological science including psychometrics social cognition cognitive behavioral therapy behavior genetics personality health industrial organizational psychology although mrp fruitful drawing field attention subtle forms prejudice far underdeveloped conceptual methodological fronts warrant real world application conclude suggestions advancing scientific status mrp recommend abandonment term microaggression call moratorium microaggression training programs publicly distributed microaggression lists pending research address mrp scientific limitations
protein glycation major mechanism establishing secondary complication diabetes mellitus effective inhibition process prevent progression disorder secondary complications aminoguanidine amg limonene known protein glycation inhibitors aim present study demonstrate differential mechanisms action study whether combinatorial therapy act synergistically lower dosage thereby lower toxicity treatment secondary complications diabetes glycation presence urea inhibited amg amg effective reducing protein carbonyl formation spr studies revealed binding reduces affinity bsa glucose demonstrated increase degrees thermal transition dsc studies reduction degrees amg proving effectively stabilize protein structure combinatorial treatment amg prevented alpha helix beta sheet transitions bsa inhibited age related fluorescence pentosidine formation respectively combination reduce dosage amg almost twenty times paving way effective protein glycation inhibition without toxicity published elsevier
prader willi syndrome pws rare complex multisystem genetic disorder includes hypothalamic dysfunction hyperphagia cognitive behavioral problems increased anxiety compulsive behaviors individuals pws deficit oxytocin producing neurons paraventricular nucleus hypothalamus oxytocin plays role regulation feeding behaviors social interactions emotional reactivity issues significantly affect quality life individuals syndrome performed double blind placebo controlled crossover study children pws three academic institutions using days intranasal oxytocin days intranasal placebo spray followed week washout period patients returned days treatment alternate source questionnaires including aberrant behavior checklist social responsiveness scale repetitive behavior scale revised hyperphagia questionnaire well clinical global impression scales administered blood testing sodium potassium glucose levels days diet recall scales factor improvement day day favored oxytocin placebo single factor showed statistically significant difference groups day drug effect appeared diminished day evidence difference oxytocin placebo safety lab parameters min post dose vital signs weight diet parameters results study suggest low dose intranasal oxytocin safe individuals pws may result reduction appetite drive improvements socialization anxiety repetitive behaviors long term studies larger population participants necessary confirm findings results study encouraging oxytocin may safe effective treatment many issues negatively impact individuals pws
objective compare expected probability pregnancy hysteroscopic versus laparoscopic sterilization based available data using decision analysis study design developed evidence based markov model estimate probability pregnancy years three different female sterilization procedures hysteroscopic laparoscopic silicone rubber band application laparoscopic bipolar coagulation parameter estimates procedure success probability completing follow testing risk pregnancy different sterilization procedures obtained published sources results base case analysis points time sterilization procedure initial cumulative risk pregnancy sterilization higher women opting hysteroscopic either laparoscopic band bipolar sterilization expected pregnancy rates per women year hysteroscopic sterilization laparoscopic silicone rubber band application laparoscopic bipolar coagulation respectively years cumulative pregnancy rates per women respectively sensitivity analyses suggest three procedures would equivalent pregnancy risk approximately per women years probability successful laparoscopic band bipolar sterilization drops successful coil placement first hysteroscopic attempt increases probability undergoing hysterosalpingogram increases conclusion based available data expected population risk pregnancy higher hysteroscopic laparoscopic sterilization consistent existing contraceptive classification future characterization hysteroscopic sterilization distinguish perfect typical use failure rates elsevier inc rights reserved
background validate short version dementia diagnosis standard version dementia diagnosis clinical diagnosis examine concurrent validity world health organisation disability assessment schedule care needs multiethnic asian older adult population singapore methods data well singapore elderly study nationally representative survey older singapore resident population aged years used validity short version dementia diagnostic criteria derived community screening instrument dementia modified consortium establish registry alzheimer disease word list delayed recall euro depression screen examined standard version dementia diagnosis clinician diagnosis gold standard concurrent validity tested examining relationships short version dementia diagnosis disability care needs results total respondents completed data short version diagnosis included study majority respondents chinese descent malays indian descent belonged ethnic group found short version dementia diagnosis showed almost perfect agreement standard version dementia diagnosis kappa auc substantial agreement clinical diagnosis kappa auc weighted prevalence dementia population slightly higher based short version diagnosis standard version diagnosis also found short version dementia significantly associated higher disability beta needed care occasionally much time conclusions study found short version dementia diagnosis excellent validity diagnose dementia multiethnic asian population singapore research required determine usefulness diagnosis clinical practice institutional settings aid early detection intervention dementia
sexual violence women girls commonplace papua new guinea png experiences women rightly given central place institutional responses sexual violence men perpetrate violence often overlooked oversight undermines effectiveness prevention efforts paper draws interviews conducted young men part qualitative longitudinal study masculinity male sexuality rural highland area png explores one aspect male sexuality men narratives sexual violence striking data collective enactment sexual violence women girls reported everyday accepted practice amongst young men however women girls described equally risk transgress gender roles roles inscribed reinforced patriarchal structures greater risk address situation efforts reduce sexual violence women girls require increased focus male centred intervention critically engage forms patriarchal authority give license sexual violence understanding perceptions experiences men perpetrators sexual violence critical first step process changing normative perceptions gender task crucial reducing sexual violence countries png
investigated effect functional insertion deletion polymorphism angiotensin converting enzyme ace gene response interferon ifn therapy croatian slovenian patients multiple sclerosis total ifn treated patients responders nonresponders nrs genotyped pcr ace genotype distribution allele frequencies differ female nrs however male nrs tended greater prevalence genotype odds ratio confidence interval significantly higher frequency allele odds ratio confidence interval male multiple forward stepwise regression analysis indicated negative response ifn therapy associated ace genotype men multiple change higher pretreatment relapse rate men multiple change women multiple change ace polymorphism pretreatment relapse rate accounted approximate ifn response variability among men sample studies larger number patients different populations necessary evaluate preliminary findings
identification nonlinear block oriented models extensively studied presence process noise precisely location block oriented model essentially influence development consistent identification algorithm paper proposed aim localize process noise block oriented model accurate nonlinear modeling end response wiener hammerstein system theoretically analyzed disturbance component output caused process noise preceding static nonlinearity shown dependent input signal inspired theoretical observation simple new protocol developed determine location process noise respect static nonlinearity using input signal periodic nonstationary within one period addition proposed technique promising detect type certain static nonlinearity dead zone saturation finally validated simulated example real life benchmark
measurements via different techniques crystal benzoic acid led conflicting conceptions tautomerism statistical disorder diffraction semiclassical jumps relaxometry quantum states vibrational spectroscopy argue conflicts follow prejudice nuclear positions eigenstates pre existing measurements variance principle complementarity propose self contained quantum theory first new single crystal neutron diffraction data accord long range correlation proton site occupancies introduce macroscopic scale quantum state emerging phonon condensation nuclear positions eigenstates indefinite quantum measurements incoming wave neutron photon entangled condensate realizes transitory state either space static nuclear coordinates diffraction symmetry coordinates spectroscopy relaxometry derive temperature laws proton site occupancies relaxation rate compare favorably measurements elsevier rights reserved
organic rankine cycles orc used convert lowgrade heat sources power current research development investigate small scale variable heat sources application waste heat recovery many experimental data orc available feed pump performances achieved lower expected authors reported cavitation issue pump performance non negligible impact orc performance especially transcritical cycles operations diaphragm pumps three different test benches different fluid pump size analyzed semi empirical model pump power chain proposed validated energetic analysis show highlevel losses variable speed drive electric motor mainly due design oversizing model analysis reciprocating pump volumetric efficiency proposed taking account fluid properties finally cavitation limits different conditions calculated required net positive suction head npshr calculated found accordance manufacturer limits water pump vibration sensor could used cavitation monitoring work gives information orc feed pump simulation design operation elsevier ltd rights reserved
power system monitoring basis realizing operation safety stability increasing integration renewable energy generation along growing diffusion nonlinear loads micro generators complicates characteristics low voltage grid leads new requirements synchronized dynamic monitoring low voltage electrical network unfortunately signal waveform low voltage grid polluted heavy noises influence estimation accuracy synchronized frequency measurement low voltage side firstly paper summarizes noise characteristics synchronized frequency measurement low voltage side including white gaussian noise random impulsive noise periodic impulsive noise secondly based noise characteristic median filtering mean filtering methods analyzed best choice fast noise filter thirdly optimal parameter filter analyzed simulation optimal length filter window determined according simulation result condition snr known finally one filtering case frequency signal recorded pmu light analyzed proves noise filtered effectively filter worthy emphasize fast filtering method good choice measurement preprocessing various online applications synchronized frequency measurement low voltage network
objective several studies knee osteoarthritis suggest intra articular administration hyaluronic acid products may relevant option management patients persistent pain aim study report data efficacy guided hyalone hyalubrix injections large population patients hip osteoarthritis repeated least times per year seven years patients methods prospective post marketing cohort study data collected antiage registry values lequesne index pain vas nsaids intake global medical patients assessments evaluated every six months baseline end follow seven years later inclusion criteria age years symptomatic hip osteoarthritis least year duration months follow patients received hyaluronic acid injections least every six months using ultrasound guidance ensure accurate placement results patients included study patients categorized age classes gender body mass index bmi groups show statistically significant reduction time points compared baseline values lequesne index pain vas nsaids intake global medical patients assessments slight differences subgroups overweighted obese years patients conclusions study supports clinical efficacy safety hyalone hyalubrix patients affected osteoarthritis first study reporting large cohort patients different categories long follow seven years data confirm proper use ultrasound guided viscosupplementation background therapy management hip osteoarthritis
analyze possible factors associated quality life qol mothers preterm infants low birth weight vlbw first years delivery world health organization quality life whoqol bref scores compared correlated maternal infant related sociodemographic clinical variables maternal discharge months delivery multiple linear regression models fitted investigate effect variables mothers qol whoqol bref physical domain scores higher compared maternal variables contributed maternal qol scores stable marital union family income evangelical religion beck depression inventory bdi score infants variables affected maternal qol posthemorrhagic hydrocephalus phh bronchopulmonary dysplasia bpd female gender snappe severity score mothers preterm infants vlbw exhibited transient improvements physical well first year delivery presence depressive symptoms mothers diagnosis phh bpd negatively associated qol social religious economic aspects also important factors qol mothers preterm infants vlbw
present analysis study steady mixed convection boundary layer flow past vertical cone embedded porous medium subjected convective boundary condition governing partial differential equations reduced coupled nonlinear ordinary differential equations using similarity transformation solved numerically shooting method assisting opposing flows considered influence convective heat transfer parameter analysed discussed graphs dual solutions found exist case opposing flow national laboratory aeronautics astronautics production hosting elsevier open access article license http creativecommon org licenses
mountains along northwestern coast ellesmere island canada possess highest peaks nearest pole geography combined atmospheric thermal inversion restricted similar much long arctic night provides excellent opportunities uninterrupted cloud free astronomy provided challenges incredibly remote locations overcome present miniaturized robotic observatory deployment high arctic mountaintop system tested operability precise optical instruments winter logistics installation maintenance summer called ukpik inuktitut name snowy owl deployed two sites accessible helicopter north degrees latitude one rock elevation another glacier instrument suite included first sky viewing camera later addition small telescope monitor polaris protected retractable weather proof enclosure expanding include narrow field drift scanning camera studying extra solar planet transits also investigated implemented unique restriction run batteries recharged primarily wind turbine supplementary power came methanol fuel cell electrical generator communications via iridium satellite network system design lessons learned three years operation discussed along prospects time domain astronomy isolated high elevation polar mountaintops
classical chromosome philadelphia negative myeloproliferative neoplasms mpns group disorders share clinical hematological histological features proinflammatory cytokines tumor necrosis factor alpha tnf alpha elevated patients mpn aim study verify association polymorphisms tnf gene bcr abl negative mpn population blood samples obtained mpn patients genotyped jakvf mutation tnf polymorphisms using pcr rflp thirty three patients polycythemia vera essential thrombocythemia primary myelofibrosis pmf unclassifiable mpn mpnu included study jak mutation detected patients observed significant increase frequency tnf genotype mpn patients compared controls distribution genotypes allelic frequencies tnf significantly different among mpns jakvf positive pmf controls data demonstrated polymorphisms tnf tnf associated mpn development population triggered jak mutation published elsevier inc
word clouds widely used present contents themes text summary visualization paper propose new semantic word cloud taking account word semantic meanings distributed word representation applied accurately describe semantic meaning words word similarity graph constructed based semantic distance words lay words compact aesthetic manner word related interactions introduced guide users fast read understand text apply proposed word cloud user generated reviews different fields demonstrate effectiveness method
microglia play pivotal role innate immunity brain development mature myeloerythroid progenitor cells yolk sac colonize brain establish resident population tissue macrophages postnatal brain exert phagocytosis induce inflammatory response invading pathogens microglia also act guardians brain homeostasis surveying microenvironment using motile processes cortical spreading depression csd slowly propagating min wave rapid near complete depolarization neurons astrocytes followed period electrical suppression distinct population cortical neurons csd implicated brain migraine aura csd like events also detected stroke traumatic injury csd causes considerable perturbation ionic environment brain may readily detected microglia although csd known activate microglia role microglial activation csd related neurological disorders remains poorly understood article first provide overview microglial development multiple functions microglia review existing data relationship microglia csd discuss relevance csd induced microglial activation neurological disease
considering increasing energy demands still challenge find finite resources alternative energy owing wide range applications transparency simple structure low cost dye sensitized solar cells dsscs extensively studied one promising new generation silicon based solar cells last decade tremendous research efforts invested improve efficiency solar energy conversion dsscs review overview various strategies lead better performance stability fabricated cell recent challenges associated nanostructured electrodes device layer structure design types dyes electrolytes dsscs performance studied discussed
enf electrical network frequency fluctuates instantaneously nominal value depending increase decrease power consumption power production grid network enf sourced noise component added audio recordings mains power sourced electromagnetic field acoustic mains hum exists use component recording date time audio file verified work existence estimation acoustic mains hum sourced enf noise audio files studied analysing acoustic noise emitted several devices frequently used home workplace detection file recording time truly examined computation similarity enf signals estimated audio recordings reference enf obtained help circuit connected power grid network behaviour dynamic microphone electret microphone towards acoustic mains hum investigated extent acquiring information recording device type settings audio files analysed besides part work enf estimation videos social media also investigated
introduction aim study evaluate results surgical stabilisation hyperextension injuries thoracolumbar spine patients ankylosing spinal disorders using two different treatment strategies conventional open rigid posterior instrumentation percutaneous less rigid posterior instrumentation surgical non surgical complications postoperative radiological course clinical outcome final follow comparatively assessed moreover sought discuss important biomechanical surgical aspects specific posterior instrumentation ankylosed thoracolumbar spine well elaborate advantages limitations proposed new treatment strategy involving percutaneous less rigid stabilisation fracture reduction postoperative mobilisation materials methods january june consecutive series patients included study posterior instrumentation performed either using open approach rigid bars open rigid group via percutaneous approach using softer bars percutaneous less rigid plr group complications well radiological course retrospectively assessed patient outcome evaluated final follow using validated outcome scores vas spine score odi rmdq parker mobility score barthel score whoqol bref results surgical complications occurred frequently group requiring revision surgery two patients revision surgery plr group rate postoperative complications lower plr group well complications per patient respectively fracture reduction restoration pre injury sagittal alignment postoperative mobilisation occurred within first weeks plr group within months group clinical outcome final follow good groups relevant loss vas spine score pain function parker mobility score mobility barthel index social independency compared pre operative values conclusions study indicates proposed treatment concept involving percutaneous less rigid posterior instrumentation fracture reduction postoperative mobilisation feasible seems facilitate adequate reduction restoration pre injury sagittal alignment might potential reduce rate complications management hyperextension injuries ankylosed thoracolumbar spine
early life cognitive enrichment may reduce risk experiencing cognitive deterioration dementia later life however intervention prevent delay dementia likely taken mid later life hence investigated effects environmental enrichment wildtype mice mouse model beta neuropathology app swe months age months housing standard laboratory cages app swe healthy wildtype mice randomly assigned either enriched standard housing months age wildtype mice showed altered synaptic protein levels relatively superior cognitive performance afforded environmental enrichment environmental enrichment associated alterations beta plaque pathology neocortex hippocampus app swe mice however significant increase synaptophysin immunolabeled puncta hippocampal subregion app swe mice detected significant synaptic density changes observed region prefrontal cortex moreover significant increase hippocampal bdnf detected app swe mice exposed however changes detected neocortex animals results demonstrate mid later life cognitive enrichment potential promote synaptic cognitive health ageing enhance compensatory capacity synaptic connectivity pathological ageing associated beta deposition
humans limited capacity processing integrated items information working memory thus inevitable commit errors challenged high memory loads however neural mechanisms determine accuracy response high memory loads still remain unclear high temporal resolution electroencephalography eeg technique makes best tool resolve temporal dynamics brain networks eeg defined microstate quasi stable scalp electrical potential topography represents momentary functional state brain thus possible assess information processing currently performed brain using eeg microstate analysis hypothesize eeg microstate preceding trial could determine outcome visuospatial working memory vswm task twenty four healthy participants performed high memory load vswm task brain activity recorded using eeg four microstate maps found represent functional brain state prior trials vswm task one pre trial microstate map found determine accuracy subsequent behavioural response intracranial generators pre trial microstate map determined response accuracy localized visuospatial processing areas bilateral occipital right temporal limbic cortices results imply behavioural outcome vswm task could determined intensity activation memory representations visuospatial processing brain regions prior trial elsevier rights reserved
paper argues intergovernmental organisations igos play significant role processes system transformation required grand challenges reason potential influence socio technical regimes connected policy areas authority supported mandates moral standing technical expertise igos act two ways operating high level political support organisations guide priority setting norm development definition collective problems solutions including sti aspects establishing shared vision involving public private actors igos implement protect novel practices reinforce new norms legally binding agreements creation new spaces international collaboration processes examined field global health outside pressure directed intellectual property rules connection access medicines prompted define health challenge need stimulate innovation ensure wide access technology time two solutions implemented igos achieve goals analysed medicines patent pool designed unitaid fulfil access innovation needs relation hiv aids drugs wipo search set wipo support collaboration accelerate discovery product development neglected tropical diseases malaria tuberculosis author published elsevier
aim study report frequent psychosocial difficulties psds patients parkinson disease explore relationship psds disability quality life qol address predictors psds patients interviewed using protocol composed questionnaire investigating psds paradise qol disability comorbidity social support questionnaires scales resilience personality traits empathy physician frequent psds reported spearman correlation used address relationship paradise qol disability measures multiple linear regression performed investigate predictors paradise eighty patients enrolled women mean age years frequent psds related cognitive motor slowness tiredness sleeping facing things depressive mood anxiety paradise correlated disability rho qol rho lower qol higher disability early age onset shorter disease duration significant predictors psds adjusted paradise easy use questionnaire could contribute toward describing impact patients life extensively thus helping define tailored interventions copyright wolters kluwer health inc rights reserved
background proximal humerus fractures remain challenging treating orthopaedist initial diagnosis classification corresponding management account approximately fractures incidence expected increase secondary ageing population associated osteoporosis fractures third common type fragility fractures distal radius hip fractures patients aged years materials methods study patients treated followed period years july july department orthopaedics siddhartha medical college vijayawada andhra pradesh study patients treated philos locking plate intra postoperative period followup done years outcome patients complications studied throughout period results study cases treated locking plates age incidence common years age group common males cases common right side cases study maximum number cases belong neer part surgical neck humerus fractures cases followed fracture dislocations cases three part fractures cases mean followup study months ranging months months average time union weeks study ranging weeks weeks cases operated cases within days injury cases within days remaining cases days due delay presentation adequate reduction achieved cases cases mean neck shaft angle calculated immediate postoperative radiographs degrees mean angle fracture healing degrees mean degrees varus collapse mean fall neck shaft angle initial fixation fracture healing study range motion affected increasing age study best range motion found age group years mean degrees forward flexion degrees abduction degrees external rotation degrees internal rotation range motion reduced advancing age study explained age related rotator cuff dysfunction results evaluated based constant murley score dash shoulder scoring systems cases excellent good results fair results cases two percent poor results study conclusion study conclude locking plates minimise possible complications like screw loosening screw back varus collapse associated traditional plates significant improvement functional outcome seen locking plates due early mobilisation shoulder functional outcome directly proportional reconstruction functioning rotator cuff proper rehabilitation
today wireless sensor networks wsns open source operating systems still need many efforts guarantee protocol stack succeeds delivering expected performance due subtle implementation problems unexpected interactions protocol layers subtleties often related judicious choice parameters particular related timing issues issues often visible simulation studies paper proposes low cost versatile measurement testbed demonstrates usefulness measuring performance rdc protocols demonstrate testbed helped identify bugs implementation rdc protocol
background research area psychosocial factors rehabilitation sports injuries focused risk behaviors relatively studies focused behaviors facilitate rehabilitation objective study understand psychosocial features characterize elite female football players express resilient behaviour rehabilitation first time anterior cruciate ligament acl injury reconstruction methods qualitative method used based individual person interviews video communication players incurred first time acl tear season swedish women elite football league total players first time acl interviewed post season interviews followed thematic content analysis based eight players identified showing resilient behaviors rehabilitation included final analysis results three core themes representing psychosocial factors help players cope successfully rehabilitation identified constructive communication rich interaction significant others strong belief importance efficacy one actions iii ability set reasonable goals conclusions findings suggest three core themes psychosocial factors characterize first time acl injured elite female football players showing resilience rehabilitation acl reconstruction suggestions medical teams ways support communication self efficacy goal setting rehabilitation process provided
functional neuroimaging studies suggested existence largely distinct social cognition networks one theory mind taking others cognitive perspective another empathy sharing others affective states address whether networks also dissociated level brain structure combined behavioral phenotyping across multiple socio cognitive tasks tesla mri cortical thickness structural covariance analysis healthy adults recruited across sites regional thickness mapping provided partial support divergent substrates highlighting individual differences empathy relate left insular opercular thickness correlation thickness mentalizing scoreswas found conversely structural covariance analysis showed clearly divergent network modulations socio cognitive affective phenotypes specifically individual differences theory mind related structural integration temporo parietal dorsomedial prefrontal regions empathy modulated strength dorsal anterior insula networks findings robust across recruitment sites suggesting generalizability level structural network embedding study provides double dissociation empathy mentalizing moreover findings suggest structural substrates higher order social cognition reflected rather interregional networks local anatomical markup specific regions per
environmental pollution specifically water pollution alarming developed developing countries heavy metal contamination water resources critical issue adversely affects humans plants animals phytoremediation cost effective remediation technology able treat heavy metal polluted sites environmental friendly method successfully implemented constructed wetland cws able restore aquatic biosystem naturally nowadays many aquatic plant species investigated determine potential effectiveness phytoremediation application especially high growth rate plants macrophytes based findings phytofiltration rhizofiltration sole method defined heavy metals removal water aquatic plants due specific morphology higher growth rate free floating plants efficient uptake heavy metals comparison submerged emergent plants review potential wide range aquatic plant species main focus four well known species hyper accumulators pistia stratiotes eicchornia spp lemna spp salvinia spp investigated moreover discussed history methods future prospects phytoremediation heavy metals aquatic plants comprehensively published elsevier
objectives increased arterial stiffness important determinant risk cardiovascular disease lipid profile impairment especially hypercholesterolemia associated stiffer blood vessels thus aim study determine five circulating lipid components high density lipoprotein cholesterol hdl non high density lipoprotein cholesterol non hdl low density lipoprotein cholesterol ldl total cholesterol triglycerides best predictor increased arterial stiffness urban brazilian population methods random sample individuals general population vitoria brazil years selected lipid components measured using standard methods pulse wave velocity measured using non invasive automatic device increased arterial stiffness defined pulse wave velocity results men total cholesterol associated risk increased arterial stiffness women hdl non hdl good predictors risk increased arterial stiffness however associations found postmenopausal women hdl non hdl conclusion findings indicate hdl non hdl good predictors risk increased arterial stiffness postmenopausal women urban brazilian population may useful tools assessing risk arterial stiffness
model driven development embedded systems one would ideally automate code generation model analysis model functional correctness liveness timing guarantees quantitative properties characteristically embedded systems analyzing quantitative properties like resource consumption performance requires model environment well use pstate analyze power consumption motes intended water quality monitoring recreational beaches lake ontario show system properties analyzed model checking rather classical approach based functional breakdown spreadsheet calculation model possible generate framework executable code run sensor microcontroller goal model checking approach improvement engineering efficiency
certain medical treatments involve introduction exogenous liquids lungs liquids form plugs within airways plugs propagate throughout branching network lungs forced airflow leave deposited film airway walls split bifurcations understanding resulting distribution liquid throughout lungs important effective administration prescribed treatments paper investigate numerically splitting liquid plug two dimensional pulmonary bifurcation influence transverse gravitational field splitting characterized splitting ratio ratio volume liquid plug daughter channels depends capillary number orientation bifurcation plane respect three dimensional gravitational field observed gravity induces asymmetry splitting causing splitting ratio reduced effect mitigated capillary number increased also observed exists critical capillary number plug split instead propagate entirely gravitationally favoured daughter channel also compute wall stresses bifurcation walls observe locations stresses gradients highest magnitude
adolescents involved juvenile justice system higher rates risky sexual behaviors resulting high rates sexually transmitted infections increased risk human immunodeficiency virus early complicated pregnancy parenting issues comorbid substance abuse gang association mental health issues history abused children result elevated rates girls lesbian gay bisexual transgender youths represent growing subpopulations special risks increasingly diverted community based alternatives juvenile justice involved teens obtain medical care community providers need understand risks provide appropriate optimal care
background hong kong population risk seasonal influenza infection twice year seasonal influenza significantly associated increased hospitalization children maintaining personal hygiene vaccination effective measures prevent influenza infection research demonstrates positive relationship health practices applied parents behaviour children highlighting importance parental heath education however minimal research provides understanding hong kong chinese parents teach children prevent seasonal influenza methods mixed methods research undertaken employed multiple case study approach gain understanding parental teaching practices regarding seasonal influenza prevention purposive intensity sampling adopted recruit twenty parents healthy children thematic analysis employed examine qualitative interview data quantitative survey data examined descriptively data integrated provide rigorous understanding parental teaching strategies comparisons made across cases reveal commonalities differences results five major themes identified processes parents used teach personal hygiene parent child interaction teaching approaches managing children health behaviours enhancing children healthy practices parents perspective role nurse health promotion conclusions study provided valuable insight approach hong kong chinese parents teaching children prevent seasonal influenza results indicate parents better supported develop effective strategies teach preschool children hygiene practices seasonal influenza prevention partnerships community nurses play role building effective parent child interactions enhance children learning adoption healthy practices
recent years number people around world suffer fruit allergies increased mango induce anaphylaxis two major mango allergens identified man man apart molecular weights values information known work identifies dna amino acid sequences man constructs expression system recombinant man rman firstly race assays used identify cdna fragment man subsequently full length man cdna inserted pet vector inserted plasmid transformed escherichia coli express rman conditions expression rman including iptg concentration induction temperature induction time optimized highest amount soluble rman obtained induction iptg degrees tagged rman purified using nta agarose identity verified using anti histidine antibody serum mango allergic person additionally rman identified glyceraldehyde phosphate dehydrogenase gapdh shared identity amino acid sequence gapdh wheat finally coli expression system rman established potential used immunotherapy mango allergy development assays detecting residues mango allergens elsevier inc rights reserved
normal stress applied landfill liner systems increases volume waste construction engineered landfills traditional shear tests adequately describe loading process liner system one shear test performed single sample study series laboratory tests using new test method differs traditional shear tests performed investigate repeated shear behaviors geotextile geomembrane geomembrane clay clay interfaces various normal stresses test results indicated increasing shearing times decrease peak residual shear strengths clay interfaces additionally strength parameters obtained traditional repeated shear tests used analyze global stability along liner system typical landfill results repeated shear tests limit equilibrium analysis determined significant landfill liner system anti slide design limitations tests also discussed
deficiency omega polyunsaturated fatty acids pufas alteration ratio omega omega pufas may contribute pathogenesis bipolar disorder unipolar depression recent epidemiological studies also demonstrated association depletion pufas suicide aim investigate relationship pufas suicide assess whether depletion pufas may considered risk factor suicidal behavior addition detailing potential use pufas clinical practice performed systematic review pufas suicide mood disorders searching medline excerpta medica psyclit psycinfo index medicus relevant epidemiological post mortem clinical studies january september total articles peer reviewed journals identified selected review reviewed studies suggest subjects psychiatric conditions depletion omega pufas compared control groups fatty acid depletion also found contribute suicidal thoughts behavior cases however large epidemiological studies generally supported finding depletion omega pufas statistically different controls patients diagnosed mental illness engaged suicidal behavior increasing pufa intake may relevant treatment depression however respect prevention suicide data currently supportive approach changes levels pufas may however risk factor evaluate assessing suicide risk clinical studies conducted prospectively assess whether prescriptive long term use pufas pufa deficient people depression may preventative role attenuating suicide elsevier inc rights reserved
little analysis epidemiology adult fall related fractures outwith osteoporotic population analysed patient patient fall related fractures one year period defined population documented epidemiology overall prevalence non spinal fall related fractures occurring males females respectively females aged years fractures follow falls equivalent age range males years analysis fall related fractures two one year periods shows significant increase almost age ranges years decreased incidence patients males significant increase year males also males years females greatest increase incidence year females age ranges show significant increase years decreased incidence females reasons increase incidence fall related multifactorial probably contributed inherently weaker bone younger females increased incidence conditions obesity diabetes elsevier ltd rights reserved
dastarcus helophoroides predatory natural enemy longhorned beetles relatively longer lifespan compared insects determine potential physiological roles antioxidant enzymes superoxide dismutase sod longevity aging helophoroides analyses including molecular information bioinformatics research phylogenetic relationship expression patterns combined investigation four hsods classified three groups one cytoplasmic sod two extracellular sod one sod identified characterized multiple alignments hsods highly homologous sods tribolium castaneum closely clustered together sod genes insects phylogenetic analyses comparison hsods expression different tissues stages age groups showed sod transcripts could detected examined specimens expression hsods revealed tissue specificity relatively high levels male reproductive system head low levels female reproductive systems mid gut expression analyses hsods different development stages demonstrated hsod hsod increased instar larvae whereas two extracellular sod genes hsod hsod much expressed newly emerged adults expression fluctuations hsods aging seemed less significant development exhibited relatively stable expression initial decline increased older groups relatively stable increased expression hsods may indicate strong ability sods eliminate oxidative damage products accumulated aging possibly retard aging research provides molecular biology vivo expression levels future analysis sod family helophoroides insects provides basis study sod genes contribution longevity helophoroides elsevier rights reserved
background demonstration presynaptic dopaminergic deficiency cit spect imaging useful ancillary tool diagnosis parkinson disease whilst evidence cross sectional relationship degree dopaminergic deficiency severity bradykinesia rigidity longitudinal studies rare moreover relationship motor subtypes dopaminergic deficient state well characterized aim primary aim assess correlations dopaminergic deficiency baseline cit spect imaging progression motor severity patients classified motor subtype development motor complications secondary aim assess correlation updrs iii subscores time onset motor complications methods patients abnormal baseline cit spect scans least years clinical follow classified motor subtype akineticrigid tremor dominant mixed updrs iii scores baseline yearfollow time onset motor complications recorded results cit uptake ratios inversely correlated updrs iii scores years akinetic rigid patients time onset motor complications inversely correlated updrs iii subscores bradykinesia rigidity baseline years conclusion degree dopaminergic deficiency baseline cit spect inversely correlates motor severity year follow akinetic rigid patients furthermore updrs iii subscores bradykinesia rigidity baseline show inverse correlation time onset motor complications across subtypes
using qualitative method study aims explore identify describe italian health care providers reflections contraceptive behaviors adolescents attending family health centers health care providers self perception job attitudes toward adolescent patients semi structured interviews italian health care providers conducted analyzed using thematic analysis two main themes emerged thematic data analysis regarding italian health care providers self perceptions reflections first main theme labeled adolescents contraceptive behavior included two subthemes adolescents confused unprepared contraception girls responsibility second theme labeled job attitudes adolescents included three subthemes inform educate build trustful relationships beyond personal beliefs findings study showed italian health care providers perceive nonjudgmental interpret behavior attempt answer adolescents sexual reproductive health srh needs open minded way work adolescent patients relation contraceptive behaviors led desire educate building significant long term relationship could sustain patients
multi component reactions arylhydrazopyrazoles aromatic aldehydes cylohexane dione gave pyrazoloquinazolinones addition compounds reacted elemental sulfur either malononitrile ethyl cyanoacetate give thiophene derivatives respectively compounds used synthesis tetrahydro pyrazolo pyrimido carbazol derivatives reaction phenylhydrazine similarly reaction pyrazole derivatives dimedone gave quinoline derivatives newly synthesized products evaluated met kinase prostate cancer cell lines six typical cancer cell lines mkn umg smmc promising compounds investigated tyrosin kinase kit flt vegfr egfr pdgfr compounds selected examine pim kinase inhibition activity compounds showed high inhibitions
introduction mouth eye dryness frequently reported patients multiple sclerosis side effects antimuscarinic drugs used neurogenic overactive bladder evaluated impact antimuscarinic drugs prescription symptoms methods patients consulting overactive bladder included xerostomia evaluated baseline thirty days treatment self reporting questionnaires xerostomia quality life qol xerostomia questionnaire salivary flow rate sugar test xerophtalmia evaluated self reporting questionnaire ocular surface disease index osdi schirmer test latrogenic anticholinergic impregnation evaluated anticholinergic drug scale results january december patients included mean age years mean edss mean anticholinergic impregnation treatment none correlation found anticholinergic impregnation parameters twenty two patients evaluated treatment baseline thirty days treatment mean scores respectively qol osdi mean salivary flow rates respectively positive sugar tests concerned respectively patients positive schirmer test concerned treatment conclusion eye mouth dryness exist population even prescription antimuscarinic treatment getting worse prescription symptoms reason stop efficient treatment reason find treat aetiology elsevier masson sas rights reserved
work presents rail rail operational amplifier hardened design ionizing radiation circuit level using standard layout techniques changing transistor layout instance using enclosed layout structures allows design simulation using standard models provided foundry circuit fabricated standard cmos process submitted total ionizing dose tid test campaign using radiation source dose rate rad reaching final accumulated dose krad circuit proved radiation tolerant tested accumulated dose design practices used mitigate tid effects presented discussed detail elsevier ltd rights reserved
objective present experiment analyzed effects playing violent video game player sensitivity victimized people measuring involuntary pupil dilation responses pdrs passive picture viewing paradigm examining mediating role pdr aggression method participants randomly assigned play violent video game nonviolent video game participants pdrs recorded exposed pictures alleged victims violence displayed negative neutral positive contexts competitive reaction time task also used measure aggression results participants violent game condition demonstrated lower pdr victims violence negative circumstances greater aggression participants nonviolent game condition lower pdr victims displayed negative context mediated relationship violent game play aggression conclusion negative effects playing violent games societal concern results indicate single violent gaming session reduce player involuntary pdrs pictures victimized people negative context increase participant aggression new relevant finding encourage research area
background purpose examine psoriasis atopic eczema analyzing skin roughness palpation essential precisely diagnose skin diseases however optical sensor based skin imaging systems allow dermatologists touch skin images solve problem new haptic rendering technology accurately display skin roughness must developed addition rendering algorithm must able filter spatial noises created image conversion without losing original roughness skin image study perceptual way design noise filter remove spatial noises meantime recover maximized roughness introduced understanding human sensitivity surface roughness methods visuohaptic rendering system provide user seeing touching digital skin surface roughness developed including geometric roughness estimation method meshed surface following psychophysical experiment designed conducted human subjects measure human perception developed visual haptic interfaces examine surface roughness results psychophysical experiment found touch sensitive lower surface roughness vice versa human perception senses vision touch becomes less sensitive surface distortions roughness increases interact channels visual haptic interfaces performance detect abnormalities roughness greatly improved sensory integration developed visuohaptic rendering system conclusion result used guideline design noise filter perceptually remove spatial noises recover maximized roughness values digital skin image obtained optical sensors addition result also confirms developed visuohaptic rendering system help dermatologists skin care professionals examine skin conditions using vision touch time
aim paper assess several pathways harmonised european policy framework supporting renewable electricity res horizon according different criteria pathways combine two main dimensions degrees harmonisation instruments design elements quantitative model based analysis green model provided results simulations show small differences evaluated cases regarding effectiveness policy pathways score similarly respect rese deployment different degrees harmonisation whether using feed tariff feed premium quota system banding quota without banding scheme contrast policy costs clearly differ across pathways differences mostly attributed instruments rather degrees harmonisation also case criteria static dynamic efficiency socioeconomic environmental benefits terms emissions fossil fuels avoided degree harmonisation choice instrument influence distribution support costs across countries finally findings suggest keeping strengthened national support leads similar results policy pathways
introduction arthroscopic lavage well established minimally invasive treatment septic arthritis adults use arthroscopy pediatric population typically restricted sports injuries deformity previous research arthroscopic lavage septic joints pediatric population limited case reports small case series older children aimed evaluate safety efficacy arthroscopic treatment various joints young children methods children aged treated arthroscopic lavage single portal adequate inflow outflow cases second portal used knees joints synovectomy indicated drains placed portal site remained place days antibiotics managed infectious disease service results nine hips knees ankles shoulders included portal placement visualization adequate lavage straight forward joints transient femoral nerve palsy arthroscopy associated complications iatrogenic damage difficult drain placement conversion open two patients required repeat arthroscopic lavage disease eradication one required second admission third patient underwent open irrigation following arthroscopic lavage resultant average procedures per subject final follow average recurrence infection decreased range motion noted conclusions arthroscopic lavage appears safe quick effective alternative open arthrotomy treatment young children feasible large joint even infantile population allowing improved visualization irrigation little soft tissue dissection morbidity relatively simple technique positive results encourage regular use arthroscopic treatment even young children level evidence level case series
brazilian market international industrial products necessary check quality conformity products order protect consumer encouraging continuous quality improvement promote competition manufactures compact fluorescent lamps cfl lfc one several products national institute metrology quality technology inmetro regulates quality one lfc testing stages keep lfc supplied electric power time period period switch lfc according predefined schedule construction lfc supplied circuit done using semiconductors electronics components cause undesirable effect harmonics electrical network effects cause variety problems driving conduction stabilization laboratory circuits paper presents analysis suggests solution problem energy quality one laboratories accredited inmetro
large scale construction company plays vital role infrastructure construction constractors commonly seen working concurrent projects single project oriented way construction management longer meet increasing demand firm growth programme management advantages project management research interaction construction projects contractor becomes necessary paper theoretical analysis programme contracting organic growth growth stages firm applied investigate coupling interaction programme contracting firm growth growth stages identified key influential factors stage discussed result provides solid theoretical basis future evaluation decision making corporational programme contracting
interdisciplinary exploration vital education century manuscript outlines innovative laboratory based teaching method combines elements biochemistry molecular biology kinesiology health science computer science manufacturing engineering give students ability better conceptualize complex biological systems utilize technology available universities print three dimensional scale models actual human muscle cells myofibers bioplastic materials methodological approach could applied nearly cell type molecular structure advancement significant historically two dimensional myocellular images proven insufficient detailed analysis organelle organization morphology imaging fills void providing accurate quantifiable myofiber structural data manipulating tangible models combats limitation gives students new perspectives alternative learning experiences may assist understanding approach also exposes learners human muscle cell extraction isolation targeted fluorescence labeling confocal microscopy image processing via open source software printing bioplastic scale models larger actual cells creating physical models may student interest invisible world molecular cellular biology furthermore interdisciplinary laboratory project gives instructors biological disciplines new teaching tool foster integrative thinking international union biochemistry molecular biology
high penetration renewable generation increase requirement operating reserve frequency response due variability uncertainty limited inertia capability although importance optimal scheduling widely studied scheduling yet fully investigated context paper proposes computationally efficient mixed integer linear programming formulation full stochastic scheduling model simultaneously optimizes energy production underfrequency load shedding using value lost load voll single security measure model optimally balances cost associated provision various ancillary services benefit reduced cost load curtailment proposed model applied system demonstrate effectiveness impact installed capacity wind generation setting voll also analyzed
many recent applications computer graphics human computer interaction adopted colour cameras depth cameras input devices therefore effective calibration types hardware taking different colour depth inputs required approach removes numerical difficulties using non linear optimization previous methods explicitly resolve camera intrinsics well transformation depth colour cameras matrix hybrid parameters introduced linearize optimization hybrid parameters offer transformation depth parametric space depth camera image colour parametric space colour camera image combining intrinsic parameters depth camera rotation transformation depth camera colour camera rotation transformation intrinsic parameters explicitly calculated hybrid parameters help standard factorisation test algorithm synthesized data real world data ground truth depth information captured microsoft kinect experiments show approach provide comparable accuracy calibration state art algorithms taking much less computation time herrera method raposo method due advantage using hybrid parameters
background middle genicular artery mga responsible blood supply cruciate ligaments synovial tissue traumatic sports injuries surgical procedures open arthroscopic cause vascular damage little attention devoted establish safe parameters mga purpose investigate anatomy mga relation posterior structures knees mainly posterior capsule femoral condyles establish safe parameters avoid harming mga study design descriptive laboratory study methods dissection mga performed fresh unpaired adult human cadaveric knees macroscopic degenerative traumatic changes previous surgeries specimens meticulously evaluated emphasis preservation mga distances mga medial lateral femoral condyles measured mann whitney test used statistical analysis results specimens mga emerged anterior aspect popliteal artery distal superior genicular arteries short distal trajectory toward posterior capsule entered proximal oblique popliteal ligament artery lay midportion condyles distance posterior aspect tibia point entry mga posterior joint capsule range correlation individual height distance entrance point mga posterior joint capsule posterior superior corner tibia conclusion middle genicular artery lies midportion medial lateral femoral condyles clinical relevance knowledge important preservation blood supply posterior knee surgical procedures settle secure distance posterior aspect tibia mga input could decrease prevent iatrogenic vascular injury risk mga
present study aimed examine effects novel avatar interviewing aid memory interviews children autism spectrum disorder asd thirty children recruited study age half asd boys girls half neurotypical boys girls children participated target event subsequently interviewed week later either avatar interviewer human participants also asked six misleading questions aimed examine suggestibility bayesian analysis showed increase memory performance groups children interviewed avatar interviewer effect exacerbated children asd results showed encouraging implications future applications
concept space mapping applied first time design microwave dispersive delay structures ddss ddss components providing specified group delay versus frequency responses real time radio systems ddss considered paper formed cascaded coupled sections first shown aggressive space mapping provide sufficient accuracy synthesis ddss address issue propose predistortion space mapping technique compared aggressive space mapping technique provides enhanced accuracy compared output space mapping provides greater implementation simplicity two full wave one experimental examples provided illustrate proposed predistortion space mapping technique
storm water pond effectiveness treat particulate bound pollutants urban runoff depends hydraulic behavior departures ideal plug flow short circuiting mixing pose hindrances pond design goal study assess importance wind storm water pond hydraulics high resolution acoustic velocity measurements conducted deep pond dry weather results suggest winds drive turbulent three dimensional flow regime including lateral circulation vertical exchange flows fully developed surface layer representing water depth drift scaling wind speed ground observed downwind section pond wind induced vertical mixing short circuiting basin scale mixing estimated occur faster typical nominal residence time storm water ponds wind therefore important hydraulic driver small water systems may potentially reduce treatment performance local landscaping may used wind mitigation measure
objective aims study clarify state information regarding opioids families kinds experiences opioids patient followed outpatient inpatient participants study part cross sectional nationwide survey bereaved families patients cancer namely japan hospice palliative care evaluation study participants study comprised bereaved families experienced death family member period january december certificated palliative care units main outcome measures response question much improvement needed information regarding opioids answered improvement necessary answered improvement slightly necessary answered improvement necessary answered improvement extremely necessary regarding anxiety use opioid found respondents indicated opioids safe respondents indicated opioids relatively safe respondents indicated opioids safe respondents indicated opioids safe information obtained opioids found families agreed item would like clearly explained drugs medical purposes safe patient develop drug addiction life expectancy reduced conclusion study important families patients cancer explained profound careful information opioid
colorectal cancer one common types inflammation based cancers occurred due growth spread cancer cells colon rectum previously genetic association cell cycle genes proto oncogenes tumor suppressors proved studies association immune related genes killer cell immunoglobulin like receptors kirs thus intend perform meta analysis find association different genes kir susceptibility affected colorectal cancer overall population four studies investigated ourmeta analysis individuals individuals colorectal cancer individuals control groups analyses concluded colorectal cancer affected kirds also protecting gene result shows inflammatory basis cancer words contrast leukemia blood cancers colorectal cancers seem affected hyper activity natural killer cells nks whys therefore paradox suggested investigated published elsevier inc
soil erosion serious environmental threat mediterranean region due torrential rainfalls contributes degradation agricultural land techniques rainwater harvesting may improve soil water storage increase agricultural productivity could result effective land usage reservoir tillage effective system harvesting rainwater scientifically evaluated like tillage systems suitability conditions spain determined investigate quantify water storage reservoir tillage could adapted improve infiltration harvested rainwater laboratory scale rainfall simulator developed rainfall characteristics including rainfall intensity spatial uniformity raindrop size confirm natural rainfall conditions simulated sufficient accuracy simulator auto controlled solenoid valve three pressure nozzles used spray water corresponding five rainfall intensities ranging year return period uniformity coefficients order assess reservoir tillage method surface slopes three soil scooping devices identical volume used make depressions following forms truncated square pyramid triangular prism truncated cone depressions compared control soil surface depression loam soil used study results show reservoir tillage able reduce soil erosion surface runoff significantly increase infiltration significant difference depressions control compared control depression reduced surface runoff sediment yield concentration elsevier rights reserved
nowadays computer graphics art painting creation trend paper presented computer model capable generating effect gouache four parts model including brush unit design pigment simulation pigment diffusion high level control mechanism model could applied directly traditional polygonal models results demonstrating capabilities model also given
predicting final embedment depth dynamically installed anchor key prerequisite reliable calculation anchor capacity paper investigates embedment characteristics dynamically installed anchors normally consolidated overconsolidated clay series centrifuge tests involving model anchor instrumented microelectric mechanical system mems accelerometer enabling full motion response anchor established data used assess performance anchor embedment model based strain rate dependent shearing resistance fluid mechanics drag resistance predictions database anchor installations formed study literature result calculated anchor embedment depths within measurements interesting aspect consistent across entire database relates strain rate dependence frictional resistance relative bearing resistance predictions reveal strain rate dependency may indeed higher frictional resistance although soil strength lower fully remoulded strength considered reference strength suggests water may entrained along boundary layer anchor soil interface installation
advent industrial revolution wheels development never slowed terms technology number machines increased need operators handlers machines increased number machines need automatic control raised necessity led field control engineering industries early understand importance discipline foundation set branch engineering paper analyzed educational status india different levels engineering education accordance control engineering paper gives idea current industry needs availability literature tools labs subject content available online subject purpose paper also indicate direction field led india result current developments ifac international rderation automatic control hosting elsevier ltd rights reserved
social comparisons social networking sites problematic individuals however never examined parenting context pressure mothers portray perfect parents may high aim current study examine associations making social comparisons social networking sites mothers parenting mental health romantic relationship outcomes imom project mothers completed number questionnaires regarding social media use parenting behaviors health outcomes results revealed making social comparisons social networking sites related parenting outcomes form higher levels parental role overload lower levels parental competence perceived social support relationship outcomes form conflict social networking sites perceiving less positive coparenting relationships higher levels maternal depression study adds growing literature suggesting making social comparisons online may associated number negative outcomes extends context mothering study implications way mothers use social media specifically use social comparisons elsevier ltd rights reserved
background mesenchymal stem cells mscs show therapeutic efficacy many different age related degenerative diseases including alzheimer disease little currently known whether aging impacts transplantation efficiency mscs methods study investigated distribution intravenously transplanted syngeneic mscs derived young aged mice young aged transgenic app alzheimer disease mice mscs male donors transplanted female mice distribution pattern monitored pcr using chromosome specific probes biodistribution transplanted mscs brains app mice additionally confirmed immunofluorescence confocal microscopy results four weeks transplantation young mice young mscs found lung axillary lymph nodes blood kidney bone marrow spleen liver heart brain cortex contrast young mscs transplanted aged mice found brain cortex young aged mouse recipients transplantation aged mscs showed biodistribution blood spleen although young transplanted mscs showed neuronal distribution brain cortex young mice exhibited wide neuronal distribution pattern brains app mice found cortex cerebellum hippocampus olfactory bulb brainstem immunofluorescent signal transplanted mscs resident microglia robust brains app mice monocyte chemoattractant levels lowest brain cortex young mice significantly increased app mice within hippocampus monocyte chemoattractant levels significantly higher aged mice compared younger app mice conclusions demonstrate vivo msc biodistribution post transplantation detrimentally affected aging neuronal health aging recipient donor mscs used attenuates transplantation efficiency clinically data would suggest aged mscs used transplantation transplantation mscs aged patients less efficacious
overactive bladder oab defined ics international continence society urgency without urge incontinence usually frequency nocturia pharmacological treatment reduced antimuscarinic recently new therapeutic class beta adrenoreceptor agonist available france encouraging results regarding tolerance main obstacle good compliance regarding antimuscarinic treatment however research still needed explore subgroup patient lower urinary tract obstruction neurological population elsevier masson sas rights reserved
background study explores association demographic clinical features quality life functioning individuals bipolar disorder methods adult participants bipolar disorder enrolled comparative effectiveness study across eleven study sites completed baseline measures medical psychiatric history current mood quality life functioning participants least mildly depressive manic hypomanic symptomatic severity randomized receive lithium quetiapine addition adjunctive personalized treatment months results participants severe depressive irritability symptoms lower quality life higher functional impairment psychiatric comorbid conditions except substance use disorder associated worse quality life average females lower quality life males patients married living married divorced separated worse functional impairment compared patients single never married composite score social disadvantage associated worse functioning marginally associated worse quality life symptom severity moderate effect social disadvantage quality life functioning conclusions findings highlight depression irritability psychiatric comorbid conditions negatively impact quality life functioning bipolar disorder study suggests individuals social disadvantage risk functional impairment
recent exponential growth nanotechnology numerous applications nanotechnology based products resulted water pollution engineered nanoparticles last decades membrane technology emerged one promising reliable techniques water purification therefore obvious candidate remove manufactured nano sized contaminants purify water nanoparticle properties play crucial role performance effectiveness membrane filtration experimental study investigates role nanoparticle size polydispersity fouling rejection development dead end microfiltration electrostatically stabilized silica nanoparticles work filtration monodisperse silica nanoparticles smaller membrane pore size similar demonstrates increasing nanoparticle diameter accelerates pore blockage development cake specific cake resistance filtration cake formed decreases increasing nanoparticle diameter filtration polydisperse nanoparticles obtained mixing monodisperse suspensions various ratios shows increasing fraction smaller nanoparticles results delayed pore blockage cake filtration occurring later stage specific cake resistance polydisperse nanoparticles always found obtained monodisperse nanoparticle suspensions increasing weight fraction larger nanoparticles results faster development nanoparticle rejection due accelerated pore blockage however highly porous structure filtration cake originating strong surface charges moderate trans membrane pressure applied cake imperfections smallest nanoparticles rejected low extent even cake filtration stage increase applied transmembrane pressure filtration polydisperse suspension resulted faster pore blockage higher specific cake resistance nevertheless rejection nanoparticles cake filtration stage improved slightly increasing transmembrane pressure elsevier rights reserved
work perform comparative analysis single dual metal dielectrically modulated tunnel field effect transistors dmtfets application label free biosensor purpose two different gate material work function phi phi used short gate dmtfet phi represents work function gate near drain end phi denotes work function gate near source end nanogap cavity gate dielectric formed removing selected portion gate oxide sensing biomolecules investigate sensitivity biosensors dielectric constant charge density within cavity region considered governing parameters work function gate optimized considered less achieve abruptness source channel junction results better tunneling improved state current atlas device simulations show dual metal sgdmtfets attains higher state current drain current sensitivity compared counterpart device finally dual metal short gate dsg biosensor compared single metal short gate single metal full gate dual metal full gate dfg biosensors analyse structurally enhanced conjugation effect gate channel coupling elsevier ltd rights reserved
paper discusses potential water savings property household urban levels application environmentally sound technologies ests well quantification using software wise water household centered measures identified allow significant reduction drinking water consumption comparatively small effort without limitation comfort furthermore method estimation water recycling rainwater harvesting utilization potential locally available renewable freshwater presented based study average drinking water consumption urban households industrialized countries could reduced approximately one third without significant investment costs either within framework new constructions remodeling water sanitation systems residential buildings using secondary water quality drinking water demand could even reduced case area wide application overall fresh water demand cities exploitation fresh water resources could significantly reduced due comparability domestic water use investigated households findings internationally transferable example countries europe asia also usa
muts alpha key component mismatch repair mmr pathway protein responsible initiating signaling pathways dna repair cell death herein investigate heterodimer post recognition post binding response three types dna damage involving cytotoxic anti cancer agents carboplatin cisplatin fdu combination supervised unsupervised machine learning techniques along traditional structural kinetic analysis applied atom molecular dynamics calculations predict muts alpha distinct response three damage types via binary classification tree supervised machine learning technique identify key hydrogen bond motifs unique type damage suggest residues experimental mutation studies combination recently developed clustering unsupervised learning algorithm rmsf calculations pca correlated motions predict type damage causes mutsa explore specific region conformation space detailed analysis suggests short range effect carboplatin primarily altering structures kinetics residues within angstroms damaged dna distinct longer range effects cisplatin fdu simulations also observe key phenylalanine residue known stack mismatched unmatched bases mmr stacks base complementary damaged base frames containing carboplatinated dna similarly phe stacks base complementary damage frames cisplatinated dna residue however stacks damaged base trajectory frames fdu substituted dna stacking interaction frames drug investigated induces unique perturbation mutsa complex indicating possibility distinct signaling event specific repair death pathway set pathways given type damage
existing research suggests various forms family violence domestic violence child abuse tend coexist cluster although link animal cruelty domestic violence well publicized little research examined various forms animal abuse possible links corresponding forms interpersonal offenses present study examined subsample obtained fbi behavioral analysis unit bau iii crimes children included criminal histories adult males arrested animal cruelty neglect sexual abuse sample described terms demographic criminal characteristics results indicated offenders sample arrested interpersonal violence least arrested sex offense rape child molestation arrested another interpersonal crime violating restraining order harassment significant relationships discovered active animal cruelty beating stabbing interpersonal violence substance abuse well sexually abusing animals sexual offending humans results point need increased collaboration animal welfare agencies social service legal entities responsible protecting domestic violence victims children elders others risk groups published elsevier ltd
cropped field microclimate thermal stability conditions depend canopy structures prevailing weather main aim study therefore characterize vertical profiles weather variables within maize zea mays canopy describe water vapour pressure deficit vpd different atmospheric soil surface conditions wide narrow runoff strips field rainwater harvesting irwh system micrometeorological measurements wind temperature relative humidity performed eight levels within canopy canopy reference levels maize reached maximum height incomplete canopy cover irwh system two important factors complicated evapotranspiration estimation namely local advection high temperatures bare soil adjacent plant rows diurnal variations water vapour related turbulence locality position thermal internal boundary layers generally advection pronounced wide runoff strips narrow strips wide runoff strips wind effective replacing air rows maintained higher driving force evaporation maximum vpd narrow strips observed reference level dry day kpa afternoon wet day vpd reached maximum kpa vpd wide runoff strips correlated negatively wind speed showed fairly positive correlation scattered values wet days rain therefore profile characteristics within plant canopies played key role determining vpd consequently could help explain transpiration rates crops hence vpd relations enhanced understanding heat energy exchange processes heterogeneous nature maize canopy irwh tillage system elsevier ltd rights reserved
aimswe investigated year outcomes three protocols pelvic floor physical therapy anticholinergic drug women wet active bladder oab methodsone hundred sixty four women randomly allocated one four interventions drug therapy bladder training pelvic floor muscle training pfmt combined pelvic floor rehabilitation cpfr includes pfmt behavioral advice active treatment group lasted months women completed year follow women responded questionnaires therefore included study outcome measures number voids per day number urgency urinary incontinence uui episodes per week completely dry rate incontinence quality life questionnaire qol years resultsafter years follow outcome measures improved significantly equally four groups median number uui episodes week dropped pfmt cpfr groups respectively dry rates pfmt cpfr groups respectively qol scores improved significantly four groups conclusionswomen suffer wet oab may experience degree long term improvement following various pelvic floor physical therapy protocols would drug therapy neurourol urodynam wiley periodicals inc
leucine rich repeat kinase lrrk recently discovered molecule associated familial sporadic parkinson disease regulates many central neuronal functions cell proliferation apoptosis autophagy axonal extension however contrast well documented function lrrk central neurons unclear whether lrrk expressed enteric neurons affects physiology gut examining lrrk mice study investigated whether enteric neurons express lrrk whether intestinal neuronal peptides iga quantitatively changed intestinal protein lysates sections prepared male cbl mice analyzed western blotting immunostaining using anti lrrk antibody respectively intestinal neuronal peptide mrnas quantified real time pcr wild type mice lrrk mice intestinal iga quantified elisa lamina propria mononuclear cells lpmcs analyzed flow cytometry evaluate ratio cells western analysis immunostaining revealed lrrk expressed enteric neurons amounts mrna vasoactive intestinal peptide neuropeptide substance increased lrrk mice accompanied increment iga however intestinal cell subpopulations altered lrrk mice first time revealed lrrk expressed enteric neurons related quantitative alterations neuronal peptide iga study highlights importance lrrk enteric neurons well central neurons
nanofibers yield potential applications areas filtration recovery metal ions drug release dentistry tissue engineering catalysts enzyme carriers wound healing protective clothing cosmetics biosensors medical implants energy storage improvement catalytic efficiency immobilized enzymes via materials engineering demonstrated preparation bioactive nanofibers nanofibers produced electrospinning followed chemical attachment model enzyme hand biological perspective almost human tissues organs deposited kind nanofibrous form structure
ischemic stroke represents one leading causes death disability united states abroad particularly patients prior ischemic stroke transient ischemic attack tia quintessential aspect secondary stroke prevention use different pharmacological agents mainly antiplatelets anticoagulants antiplatelets anticoagulants exhibit effect blocking activation pathways platelets coagulation cascade respectively clinical trials demonstrated safety efficacy antiplatelets noncardioembolic stroke prevention anticoagulants often used cardioembolic stroke prevention commonly used antiplatelets include aspirin clopidogrel aggrenox aspirin plus extended release dipyridamole furthermore commonly used anticoagulants include warfarin dabigatran rivaroxaban apixaban edoxaban drugs unique mechanism action share common adverse events gastrointestinal bleeding intracranial hemorrhage serious cases consequently physicians carefully assess benefits risks using different antiplatelet anticoagulant therapies managing patients previous ischemic stroke tia review discuses published literature major clinical trials assessing efficacy different antiplatelet anticoagulant drugs varying circumstances subsequent guidelines developed american heart association american stroke association additionally role imaging stroke prevention discussed
computer supported collaborative learning cscl aims improve education combining collaborative learning modern information communication technology opportunity exists develop successful cscl applications due increase popularity social networking online gaming among students chapter present approach promoting metacognition computer programming using collaboration computer games show cscl improve students metacognitive skills use games motivates engages students learning process together enhance qualities successful problem solver low problem solving skill identified main challenge faced novice computer programmers
adolescence crucial period emerging sexual orientation gender identity also body image disturbance disordered eating body image distortion disordered eating important pediatric problems affecting individuals along sexual orientation gender identity spectrum lesbian gay bisexual transgender lgbt youth risk eating disorders body dissatisfaction disordered eating lgbt gender variant youth may associated poorer quality life mental health outcomes pediatricians know problems occur frequently lgbt youth evidence newer treatment paradigms involving family support effective individual models care
energy harvesting wireless sensor node wsn integrates intel architecture core based near threshold voltage ntv microcontroller mcu provides mhz always always sensing aoas capability mcu implements four independent voltage frequency islands managed integrated power management unit features subthreshold voltage capable die oscillator fin pitch leakage per bit sram mcu operates across wide frequency voltage range mhz mhz dissipating achieves better energy efficiency optimum supply voltage vopt mhz cycle functional aoas wsn incorporating ntv mcu shows promise sustained operation
resource constrained scheduling problems appear different levels decisions logistics manufacturing computer networks software engineering etc usually characterized many types constraints decision variables often make difficult solve complete addition problems often characterized uncertainty resources allocations time opportunity ask questions get answers feasibility optimality schedule uncertain conditions available resources extremely important decision makers paper presents hybrid approach modeling solving robust constrained scheduling problems two environments mathematical programming constraint logic programming integrated integration hybridization well transformation problem helped reduce combinatorial problem substantially order compare effectiveness proposed approach mathematical programming approach illustrative example implemented environments data instances
eliciting empathy plays significant role encouraging charitable donations however know little incidental contextual cues facilitate empathy series behavioral neuroscience field studies show incidental exposure haptic sensation roughness smoothness increases individuals attention unfortunate others heightened attention subsequently leads enhanced empathic responses findings underscore power subtle contextual cues shaping important behaviors also point possibility developing novel intervention strategies promoting empathy prosociality society consumer psychology published elsevier inc rights reserved
background aims internet addiction paradigm criticized several shortcomings including inattention specific online behaviors distinguishing internet media insufficient focus comorbidities definitions take account constant access possible paradigm biggest casualty however may diverted attention away subtle personality changes seem occur online including users considered addicted definition methods narrative assessment literature conducted focusing internet effects personality traits revealed studies internet users results impulsivity narcissism aggression personality traits seem nurtured internet possible negative offline consequences discussion ignoring internet subtle effects personality embrace addiction model implies severe pathology makes majority internet users feel deceptively immune psychological effects new technologies also limits understanding big cultural shifts happening result conclusion internet potentially negative effect personality extension society large fundamental part online psychology one well worthy investigation
background mechanism predominant low asthma unknown objective sought study immune mechanism predominant low asthma methods previously reported cohort asthmatic patients patients immunophenotyped witht predominant asthma patients low asthma examined bronchoalveolar lavage bal fluid leukocytes cytokines mediators epithelial cell function asthma subgroups results patients predominant asthma increased beta serum amyloid levels bal fluid correlated beta levels cells expressed higher levels receptor phospho mitogen activated protein kinase anakinra receptor antagonist protein inhibited balt cell counts low asthma distinct subgroups neutrophilic asthma pauci inflammatory asthma contrasted patients predominant predominant asthma included neutrophilic asthma patients respectively bal fluid neutrophils strongly correlated bal fluid myeloperoxidase granulocyte colony stimulating factor csf levels sixty percent patients neutrophilic asthma pathogenic microorganism bal culture suggested subclinical infection conclusion uncovered critical role beta pathway patients predminant asthma subgroup patients low asthma neutrophilic asthma increased bal fluid alpha granulocyte colony stimulating factor csf levels alpha directly involved production likely contributed neutrophilic asthma sixty percent neutrophilic patients subclinical infection
unique feature adolescent social orientation heightened sensitivity peer influence taking risks however positive peer influence effects yet well understood present fmri study tested novel hypothesis examining neural correlates prosocial peer influence donation decisions adolescence participants age years made decisions anonymous groups allocation tokens group public goods game two spectator groups age peers fact youth actors allegedly online decisions task within subjects design three conditions evaluation spectators evaluated decisions likes large donations group spectator spectators present evaluative feedback displayed alone spectators feedback results showed prosocial behavior increased presence peers even participants received evaluative feedback peers peer presence resulted enhanced activity several social brain regions including medial prefrontal cortex temporal parietal junction tpj precuneus superior temporal sulcus tpj activity correlated donations suggests similar networks prosocial behavior sensitivity peers findings highlight importance peers fostering prosocial development throughout adolescence
borderline personality disorder bpd reputation challenging disorder treat due nature illness development evidence based treatments therapists becoming skilled successfully helping cohort patients common factor associated validated treatments bpd active involvement therapists example dbt one treatment therapists expected available patients coaching outside sessions however understanding benefits pitfalls associated therapists accessibility sessions relevant treatment intersession contact article three benefits intersession contact described generalize use skills improve understanding patient needs facilitate alliance article also addresses pitfalls therapists accessible patients benefits pitfalls intersession contact illustrated using case vignettes assessing function served patient contact sessions important way determine whether contact productive part treatment recommendations provided avoid detrimental outcomes therapist therapist burnout patient
politics policy important understand translational continuum pilot research randomised controlled efficacy trials roll programmes routine effectiveness studies service innovations taken health service purchasers providers others innovative interventions models care get stage implementation others fail funded
numerous studies linked consumption violent audiovisual content increase aggressive cognitions behaviors research aims clarify whether possible harmful consequences violent videogames might vary depending individual variable trait aggressiveness correlational study carried among teenagers average age years two european countries became evident means multiple regression analyses positive correlation use violent videogames aggressive behavioral intentions relevantly correlations greater amongst subjects higher scores aggression scale finally analyzing subjective experiences users violent videogames aggressive individuals manifested greater desire imitate characters interactive content admitting ended agitated even initial objective relieve tension relax practical theoretical implications catharsis theory results discussed
six randomized controlled trials comparing low fodmap diet placebo approaches indicated efficacy patients irritable bowel syndrome ibs studies provided food utilized dietitian led education variably met criticisms regarding issues choice placebo number patients studied success blinding duration interventions results uniformly positive diet real world experience low fodmap diet confirmed findings randomized studies patients respond difficulty delivering diet issue majority patients find diet easy follow dietitian led observational studies suggested durability efficacy even association reintroduction fodmaps recommended three studies comparing institution standard dietary guidelines ibs low fodmap diet found either similar improved outcomes latter low fodmap diet also similar efficacy gut directed hypnotherapy another strategy broad benefit ibs currently clinically applicable indices predict response diet conclusion clinical trials observational studies support notion dietitian led low fodmap diet ready primetime considered first line therapy patients ibs use restrictive diet appropriate
rapid urbanization process brought problems china traffic congestion air pollution water pollution resources scarcity sustainable urbanization commonly appreciated effective way promote sustainable development proper understanding sustainable urbanization performance critical provide governments support making urban development strategies policies guiding sustainable development paper utilizes method structural equation modeling sem establish assessment model measuring sustainable urbanization performance four unobserved endogenous variables economic variable social variable environment variable resource variable observed endogenous variables comprise sem model case study provinces china demonstrates validity sem model analysis results indicated assessment model could help make effective policies strategies improving urban sustainability recognizing statue sustainable urbanization
recent experiments demonstrated atherosclerosis thl dominant autoimmune condition whereas cells rarely detected within atherosclerotic lesions several studies indicated type cytokines could effective reduction stabilization atherosclerotic plaque therefore modulation adaptive immune response shifting immune responses toward cells novel vaccine could represent promising approach prevent progression thromboembolic events coronary artery disease present study silico approach applied design novel multi epitope vaccine elicit desirable immune response atherosclerosis six novel inducing epitopes selected hsp calreticulin proteins enhance epitope presentation inducing epitopes linked together aay heygaealerag linkers addition helper epitopes selected tetanus toxin fragment tterc applied induce helper lymphocytes htls responses moreover cholera toxin ctb employed adjuvant multi epitope construct designed based predicted epitopes residues length physico chemical properties secondary tertiary structures stability intrinsic protein disorder solubility allergenicity chimeric protein analyzed using bioinformatics tools servers based bioinformatics analysis soluble non allergic protein kda molecular weight designed expasy protparam classified chimeric protein stable protein addition predicted epitopes chimeric vaccine indicated strong potential induce cell mediated immune response shift immune responses toward protective immune response various silico analyses indicate vaccine qualified candidate improvement atherosclerosis inducing immune responses toward helper elsevier ltd rights reserved
mimicking appearance real world longstanding goal computer graphics several important applications feature film architecture medical industries images well designed shading important tool conveying information world shape function computer aided design cad model mood movie sequence however authoring content often tedious task even undertaken groups highly trained experienced artists unsurprisingly numerous methods facilitate accelerate appearance editing task proposed enabling editing scene objects appearances lighting materials well entailing introduction new interaction paradigms specialized preview rendering techniques review provide comprehensive survey artistic appearance lighting material editing approaches organize complex active research area structure tailored academic researchers graduate students industry professionals alike addition editing approaches discuss user interaction paradigms rendering back ends combine form usable systems appearance editing conclude discussion open problems challenges motivate guide future research
engagement cognitive activity physical activity lifespan may counteract brain atrophy later life investigated engagement late adulthood association gray matter volume normal older adults special focus hippocampus forty five cognitively normal older individuals mean age underwent weighted mri self reported assessment whole brain voxel wise multiple regression models carried assess relationships volume adjusted age sex adjustment years education risk factors performed voxel wise analyses projected hippocampal surface views cognitive activity demonstrated independent regional associations adjustment confounders cognitive activity related greater extended brain areas including frontal temporal parietal cortices associated increased prefrontal insular motor cortices regression maps projected hippocampal surface showed common association within anterior part hippocampus although effect subtle also extended posterior part engagement late adulthood independently related regional volume notably aging vulnerable areas results support idea based interventions may suitable promote brain health late adulthood potential synergistic effects need addressed future studies including larger samples
android malware grown exponential proportions recent times smartphone operating systems android used interface manage various iot systems building management home automation systems hostile environment ability test confirm device health claims important preserve confidentiality user data paper describes study determine whether android device could secured prevent malware executing parallel trusted applications research also sought determine whether system image could protected unauthorised modifications prototype scheme meeting requirements developed tested observed prototype succeeded preventing unauthorised modification system image test device however prototype failed prevent unauthorised ipc calls single process mode
background ankylosing spondylitis chronic inflammatory disease mainly affecting spine sacroiliac joints macrophage migration inhibitory mif factor regulatory cytokine inhibits random immune cell migration mif gene promoter polymorphisms play role progression several inflammatory disorders aims investigate relationship mif gene single nucleotide polymorphism snp study design cross sectional study methods study total normal controls recruited mif gene snp analyzed polymerase chain reaction using restriction fragment length polymorphism method results significant difference groups terms genotype distribution wild type genotypes compared terms clinical characteristics significant difference average age duration disease patients conclusion significant relationship disease mif polymorphism found mif polymorphism allele may affect time onset duration disease patients
psoriasis chronic relapsing immune mediated disorder skin disease presents well featured clinical histological characteristics however aetiology disease still remains obscure current systemic therapies aim eliminate symptoms disease rather offering complete cure parangichakkai chooranam siddha oral herbal formulation widely prescribed treatment psoriasis though medication highly prescribed siddha healers mechanism treatment psoriasis remains elucidated current study utilizes integrated systems pharmacology approach decipher mechanism action comprehensive network pharmacological approach resulted construction compound target network encloses compounds protein targets disease target network constructed assembling disease proteins partners compound targets mapped network involvement controllers disease triggers disease associated comorbidities identified target pathway network raised pathway enrichment analysis identified disease specific pathways also pathways mediating secondary complications skin hemostasis wound healing desquamation itch present work sheds light mechanism action treating psoriasis work highlights pharmacological action formulation also emphasis safe herbal remedies offered siddha medicinal system elsevier masson sas rights reserved
paper new floating analog memristance simulator circuit based second generation current conveyors passive elements proposed theoretical derivations presented decribe circuit characteristics hardware proposed simulator circuit built using commercially available components theoretical derivations validated pspice simulation experimental results performance circuit tested simple example circuits results show proposed simulator circuit provides frequency dependent pinched hysteresis loop nonvolatility features exciting frequency minimum maximum memristance values memristance range adjustable simple passive element values simulator circuit frequency range khz
recent years significant advances made intelligent tutoring systems advances hold great promise adaptively supporting computer science learning particular tutorial dialogue systems engage students natural language dialogue create rich adaptive interactions promising approach increasing effectiveness systems adapt problem solving performance also student characteristics self efficacy refers student view ability complete learning objectives achieve goals characteristic may particularly influential tutorial dialogue computer science education article examines corpus effective human tutoring computer science discover extent considering self efficacy measured within pre survey coupled dialogue task events tutoring improves models predict student self reported frustration learning gains tutoring analysis reveals students high low self efficacy benefit differently tutorial dialogue student control social dialogue tutor moves increase efficiency may particularly helpful high self efficacy students low self efficacy students guided experimentation may foster greater learning time potentially increasing frustration hoped line research enable tutoring systems computer science tailor tutorial interactions effectively
background within field addiction many four fifths individuals treatment substance use disorder existing lifetime psychopathology high two thirds current psychopathology among substance dependent individuals excessive delay discounting pervasive despite evidence excessive discounting across substance use disorders studies investigated impact occurring psychopathologies sud delay discounting methods compared delay discounting currently abstaining substance users sud sud managed major depressive disorder mdd sud antisocial personality disorder apd sud managed mdd apd sud occurring psychopathology results groups sud discounted future delayed rewards significantly healthy controls case respective groups individuals apd sud individuals mdd apd sud discounted future rewards significantly substance users without comorbid psychopathology respectively conclusions overall individuals multiple psychopathologies addition substance use exacerbated deficits discounting future beyond observed substance use alone increased discounting combined substance psychopathology profiles suggest greater chance treatment failure therefore may necessitate individualized treatment using adjunctive interventions achieve better treatment outcomes elsevier ireland ltd rights reserved
introduction mild cognitive impairment common parkinson disease even early stages risk developing dementia properly track development progression cognitive impairment reliable measurement tools necessary montreal cognitive assessment currently used global cognitive screening tool recommended abbreviated diagnostic tool measure mild cognitive impairment context global cognitive function however psychometric properties montreal cognitive assessment assessed context methods data obtained parkinson progression markers initiative examine psychometric properties montreal cognitive assessment among newly diagnosed parkinson disease patients using rasch analysis results one item misfit measurement model principle component analysis indicated montreal cognitive assessment unidimensional distribution items calibrations formed logical hierarchy least challenging test items markedly target easy sample also reflected low person separation reliability participants performed items correctly indicating large ceiling effect participants obtained raw score range indicating mild cognitive impairment meaningful differential item functioning detected conclusion results suggest context early stage parkinson disease montreal cognitive assessment unidimensional measure global cognitive function implications use montreal cognitive assessment early stage parkinson disease potential improvements assessment discussed published elsevier ltd
though multi facetted disorder parkinson disease prototypically characterized neurodegeneration nigrostriatal dopaminergic neurons substantia nigra pars compacta leading severe disruption motor function accordingly dopa metabolic precursor dopamine well established treatment motor deficits parkinson disease despite long term complications dyskinesia psychiatric side effects paradoxically however despite traditional assumption dopa transformed residual striatal dopaminergic neurons mechanism action dopa neither simple entirely clear herein focussing influence upon extracellular neuromodulators intact animals experimental models parkinson disease highlight effects striatal generation functional profile dopa excluding minor role glial cells dopa principally transformed neurons yet interestingly important role serotonergic dopaminergic projections moreover addition striatum dopa evokes marked increases extracellular frontal cortex nucleus accumbens subthalamic nucleus additional extra striatal regions considering functional profile also important bear mind marked probably indirect influence dopa upon cholinergic gabaergic glutamatergic neurons basal ganglia cortex anomalous serotonergic transmission incriminated emergence dopa elicited dyskinesia psychosis finally dopa may exert intrinsic receptor mediated actions independently neurotransmission processed bioactive metabolites conclusion dopa exerts surprisingly complex pattern neurochemical effects much greater scope mere striatal transformation spared dopaminergic neurons experimental clinical clarification help improve dopa based novel strategies controlling motor symptoms parkinson disease elsevier ltd rights reserved
hybrid vehicles lithium ion cells constituting battery pack frequently used provide recover high power assist vehicle internal combustion engine ice powertrain usage present mild hybrid applications battery long discharge time conditions pack series resistance proved important parameter monitor since evolution depends cell characteristics manufacturing tolerance temperature etc resistance monitored battery management system bms reflecting available power level cell used indicator enhance security battery pack evolution used quantify aging state health soh paper presents online approach identify cell series resistance based direct estimation parameter usually identified voltage drop occurring across cell caused high current variation profile mild hybrid conditions estimated values filtered exponential moving average method limit measurement noise effect approach provides good results mild hybrid conditions minimizing computing power required
object paper outline interactive teaching model developed education innovation group new teaching methodologies mechanical manufacturing engineering technology polytechnic university madrid aim model teach subject manufacturing engineering technology mechanical technical engineering degree course based new face face methodology called learning driven electronic learning theoretical teaching laboratory teaching combined collaborative environment managed developed software combines theroretical lessons solved practical examples exercises bibliographical references webpage links self assessment tests term collaborative used describe teaching methodology whereby student student student teacher relationship teaching new model driven guidance supervision professor educational environment formally taught classes students decide pace learn resources used definition carrying practical exercises whether wish form collaborations among study time fundamental advantage model efficiency optimising learning time given necessary resources accessible student electronic teaching support laboratory practical classes take place environment combined connected theoretical concepts without break incontinuity students problems resolved personal immediate way professor addition advantages emerged equally relevant engineering training students development better communication skills well skills abilities motivation creativity increase confidence confidence decisions efficacy new teaching model ben confirmed academic results attained students academic year presented paper
background clinical features disease courses primary stabbing headache psh diverse aimed identify distinct clinical patterns psh methods prospectively screened consecutive first visit patients presented stabbing headache samsung medical centre headache clinic june march demographics headache characteristics disease courses prospectively evaluated discerning factors related chronicity time presentation clinical patterns identified based frequency daily intermittent clinical course remitted total disease duration months results patients psh included study monophasic intermittent chronic daily patterns identified median disease durations days monophasic psh months chronic daily psh years intermittent psh features monophasic psh greater severity single side locked locations attacks per day daily occurrence good treatment response chronic daily psh associated female predominance longer lasting stabs multiple migrating locations bilateral alternating sides characteristics intermittent psh included female predominance sporadic stabs less intensity conclusions study demonstrated distinct clinical patterns psh addition help early recognition disease findings suggest different pathophysiologic mechanisms future prospective studies required reveal etiologies different psh patterns optimal treatment strategies
schizophrenia disabling mental illness associated dysfunction prefrontal cortex affects cognition emotion purpose present study identify altered molecular networks prefrontal cortex schizophrenia patients comparing protein expression levels autopsied brains patients controls using combination targeted focused quantitative proteomics selected molecules possibly related schizophrenia quantification knowledge based targeted proteomics among quantified molecules grik mao significantly decreased plasma membrane cytosolic fractions respectively prefrontal cortex focused quantitative proteomics identified increased decreased proteins network analysis identified gna erk elfg signaling downregulated network proteins involved network significantly decreased furthermore searching downstream eifg revealed elfa cyfip decreased suggesting downregulation network suppresses expression cyfip regulates actin remodeling involved axon outgrowth spine formation downregulation signaling seems likely impair axon formation synapse plasticity neuronal cells could associated development cognitive impairment pathology schizophrenia biological significance present study compared proteome prefrontal cortex schizophrenia patients healthy controls means targeted proteomics global quantitative proteomics targeted proteomics revealed grik maob significantly decreased among putatively schizophrenia related proteins prefrontal cortex schizophrenia patients global quantitative proteomics identified differentially expressed proteins schizophrenia brains protein profile indicates attenuation gnaerk signaling schizophrenia brain particular eifg cyfip located downstream thegna erk network decreased suggesting attenuation signal network may cause impairment axon formation synapse plasticity brain schizophrenia patients results provide novel insight schizophrenia pathology could helpful drug development elsevier rights reserved
introduction fixed dose combination therapy sofosbuvir sof plus velpatasvir vel first pangenotypic direct acting antiviral daa single treatment regimen str treatment hepatitis virus hcv infection commercialized approved treatment hcv genotypes following approval new pharmacokinetic pharmacodynamic data reported led important clinical applications areas covered review provides summary pharmacokinetics pharmacodynamics efficacy safety sof vel therapy treatment hcv infection topics covered include data regarding drug absorption distribution metabolism excretion antiviral activity strategies clinical dose selection treatment duration expert opinion novel combination therapy containing sof plus vel taken orally daily without food excellent pharmacokinetic pharmacodynamic profile sof vel achieved high rates sustained virological response treatment naive treatment experienced patients chronic hcv genotype infection including compensated cirrhosis hiv infection
purpose androgens seems play important role prostate cancer pca pathogenesis studies reveal possible testosterone deficiency could involved pca development progress others indicate men high testosterone levels increased risk devel oping aggressive pca poor response therapy objective present study establish possible correlation serum total testosterone levels pros tate specific antigen psa clinical markers evaluating aggressiveness tumor process pca patients material methods total eighty males aged years mean age years histologically confirmed pca entered study diagnosis pca established systemic transrectal ultrasoundguided tru cut prostate biopsies cores least detected tumors graded using gleason grading system rum psa analyzed immunochemically pearson correlation statistics level significance set used data analysis results strong significant positive correlation pearson psa testosterone levels found lowest risk group highest risk group negative association parameters pearson relatively weak positive relationship pearson detected patients less aggressive tumors gleason score conclusions results confirm hypothesis low testosterone levels related poor prognosis increased severity pca
altruistic behavior varies considerably across people decision contexts relevant computational motivational mechanisms underlie heterogeneity however poorly understood using charitable giving task together multivariate decoding techniques identified three distinct psychological mechanisms underlying altruistic decision making empathy perspective taking attentional reorienting linked dissociable neural computations neural responses anterior insula temporoparietal junction tpj encoded trial wise empathy beneficiaries whereas tpj predicted degree perspective taking importantly relative influence socio cognitive processes differed across individuals participants whose donation behavior heavily influenced affective empathy exhibited higher predictive accuracies generosity whereas strongly relied cognitive perspective taking showed improved predictions generous donations tpj furthermore subject specific contributions processes donations reflected participants empathy perspective taking responses separate fmri task empatom suggesting process specific inputs altruistic choices may reflect participants general propensity either empathize mentalize finally using independent attention task data identified shared neural codes attentional reorienting generous donations posterior superior temporal sulcus suggesting domain general attention shifts also contribute generous behavior tpj overall findings demonstrate highly specific roles affective empathy tpj cognitive perspective taking precursors prosocial behavior suggest discrete routes social cognition differentially drive intraindividual interindividual differences altruistic behavior
electrodynamic bearings guide rotating objects without contact active control means consequently performance relies passive phenomena require specific models predicted case electrodynamic thrust bearings early models involved assumptions rotor axial kinematics precludes use predicting bearing behavior dynamic conditions critical studying stability aspects models require numerically solving faraday current law rotor equation motion obtain dynamics bearing thereby excluding fast identification stability properties recently parametric model without kinematic assumptions derived consists linear state space representation allows studying dynamic performance electrodynamic thrust bearings using conventional system analysis tools however model links rotor displacement currents winding two phases paper introduces model free limitation allowing consider bearings higher number phases improved copper usage potentially increased performance furthermore proposed model directly links rotor displacement force torque exerted thrust bearing without requiring solve currents also minimizes number state space equations model parameters finally addition modeling aspects set bearing topologies explored yet studied using proposed model introduced
examined association kleptomania addictive disorders including behavioral addictions fifty three individuals diagnosis kleptomania completed measures kleptomania severity semi structured clinical interviews assess morbid diagnosis addictive disorders shorter promis questionnaire spq assessing array addictive behaviors sample met criteria addictive disorder four substance use disorder four behavioral addiction kleptomania severity significantly associated compulsive work shopping measured spq results suggest need assess wide array addictive behaviors individuals kleptomania
purpose purpose paper find uncertainty factors influence transaction costs generated identify ways minimize transaction costs borne construction owner design methodology approach literature indicates consensus standard definition transaction costs construction industry detailed literature review research work transaction costs construction conducted order identify determinants transaction costs construction projects structural equation model tested data collected means survey administered construction owners findings findings indicate transaction costs borne owner minimized owner minimizes uncertainties inherent construction project making sure engineering design complete possible bids sought contractors harmonious relationships project participants fair risk allocation experience similar type projects contractor selection practices routinely detect irregular behavior research limitations implications data used research primarily based experiences public owners markets operate larger representation private owners could make conclusions general another limitation study relies survey opinions rather actual records costs hard data practical implications empirical study ever conducted transaction related issues construction industry lack common understanding transaction cost paper provides groundwork study originality value paper attempts reconcile many determinants transaction costs construction projects uncertainty considered different researchers multitude research studies
background objective little information pregnancy delivery patients hereditary angioedema due inhibitor deficiency cinh hae aim study describe effect pregnancy deliveries symptoms cinh hae review need safety treatments available study period methods retrospective review using purpose designed questionnaire cinh hae patients hospitals specialized management hae spain outcomes measured number pregnancies changes symptoms pregnancy delivery mode delivery type anesthesia delivery treatments received tolerance treatments results reviewed full term pregnancies without prior diagnosis cinh hae miscarriages induced abortions patients reported increased frequency cinh hae symptoms pregnancies presence symptoms throughout pregnancy prophylactic cinh hae therapy used pregnancies nine patients pregnancies received treatment acute attacks deliveries vaginal cesarean section necessary cases short term prophylaxis pdhcinh administered deliveries deliveries performed without premedication well tolerated anesthesia used deliveries conclusions pregnancy variable influence clinical expression cinh hae attacks tend occur frequently increase severity vaginal delivery mostly well tolerated pdhcinh prophylaxis administered prior cesarean delivery also recommended vaginal delivery additional risk factors pdhcinh always available delivery room
due intermittent nature solar energy need store heat meet needs solar light available rock bed using air heat transfer fluid htf used thermal energy storage tes concentrated solar power csp plants considered cost effective storage system however detailed works published selection identification rocks high temperature storage applications scope present study choose suitable rocks high temperature sensible heat storage shs using methodology based laboratory measurements thus experimental characterization several rock types performed experimental device made thermal conductivity measurement room temperature obtained results show gabbro rock best candidate material csp plants comparative study conventional materials found literature indicates rock efficient filler material high temperature tes obtained results correlations second selection methodology proposed order minimize steps selection using simple tests elsevier ltd rights reserved
evaluate masticatory function individuals parkinson disease levodopa period using new removable dental prosthesis total elderly individuals mean age years without mean age years recruited study participants received new complete dentures removable partial dentures two months subjects free prostheses discomfort masticatory function assessed kinesiographic device used measure range jaw motion jaw movements chewing silicone test material optocal masticatory performance determined median particle size optocal masticatory cycles maximum bite force assessed strain sensor placed bilateral first molars region data analyzed test group showed decreased range jaw motion longer duration slower velocity masticatory cycle higher value lower maximum bite force patients impaired masticatory function levodopa periods compared controls knowledge associated impaired masticatory function important dental professionals decision making related prosthetics general dental treatment
paper presented experimental study circular square footing area resting sand bed steel model footing diameter square footing width sand relative density used reinforced conditions geogrid layers used settlementload responses tests investigated results indicated ultimate bearing capacity increased square footing comparison circular footing reinforcements used embedment depth bearing capacity ratio bcr increased greatly circular footing comparison square footing bcr increases increasing number geotextile layers footings square circular reinforced conditions geogrid layers better effect circular footing comparison square footing rate increasing bcr circular footing higher square footing
purpose current investigation examine role youth anger regulation reactivity link parenting social adjustment among sample youth residing disadvantaged neighborhoods mid southwestern city using path analysis findings indicate parents responsive discipline related behaviors associated antisocial prosocial behaviors different ways parental support positively associated prosocial behavior directly indirectly anger regulation permissive discipline positively associated antisocial behavior directly indirectly anger reactivity patterns associations model remained significant even youth age sex entered covariates implications study intervention programs targeting anger regulation parenting youth families high risk settings discussed
community mobilisation promising new strategy preventing intimate partner violence ipv women low income settings however little known contextual factors socio economic cultural historical political conditions enable effective mobilisation communities ipv prevention paper draws theoretical work campbell cornish relationship context community action addressing hiv aids propose framework situating community mobilisation ipv prevention surrounding symbolic material relational contexts framework refined using empirical data case study gender based violence gbv prevention intervention rwanda including interviews members government mandated gbv committees focus group discussions members two village communities thematic analysis identifies various contextual factors needed support community mobilisation ipv prevention including broad symbolic understandings constitutes ipv capacity economically support women choose leave violent relationships mechanisms addressing silence often surrounds ipv support policy government authorities opportunities effectively challenge inequitable policy legal frameworks framework useful policy makers programme planners interested ipv prevention communities copyright john wiley sons ltd
study examined mostly lower middle income latino african american adolescents age conceptions wealth ought distributed whether judgments related adolescents views societal legal fairness immediate academic plans individually administered multipart interviews assessed conceptions regarding actual ideal wealth distribution related rawlsian judgments social system legal fairness adolescents near term life goals overall adolescents underestimated actual levels wealth inequality also preferring egalitarian distribution believed exist adolescents wealth related reasoning mostly unrelated societal personal judgments whereas societal legal fairness judgments related personal academic plans although adolescents generally negative views societal legal fairness positive fairness conceptions related greater emphasis academic plans compared younger peers older adolescents preferred somewhat wealth inequality motivational economic reasons preferred living society inequality
functional connectivity subthalamic nucleus stn sensorimotor cortex increased medication patients parkinson disease however status stn sensorimotor cortex medication patients remains unclear study resting state functional magnetic resonance imaging employed patients medication healthy controls two sample test used study change pattern stn strength bilateral stn correlated overall motor symptoms unilateral stn correlated offside motor symptoms bilateral right stn showed increased right sensorimotor cortex whereas right stn correlated left body rigidity scores patients additional subgroup analysis performed according ratio mean tremor scores mean postural instability gait difficulty pigd scores pigd subgroup showed increased right stn sensorimotor cortex medication increased stn sensorimotor cortex found related motor symptom severity medication patients anti drugs may influence hyperdirect pathway alleviate motor symptoms effect tremor subtype
though practice female genital cutting fgc framed form gender based torture studies examined prevalence impact practice among documented survivors torture article presents secondary analysis data african born women interdisciplinary clinic survivors torture results indicate demographic differences experienced fgc though larger proportion fgc group west african identified muslim many fgc process applying asylum reported sexual psychological torture cited gender basis persecution fgc group evidenced unique correlates related immigration status psychological sexual torture experiences non fgc group findings indicate female survivors torture fgc represent distinct group specific mental health needs
limited therapeutic options resolution digital artery occlusions intra arterialthrom bolysis anticoagulative thrombolytic drug successfulty restored blood flow affected digital arteries
electrochemical behavior hydroxymethyl tolterodine hmt active metabolite antimuscarinic drugs tolterodine fesoterodine used treat urge incontinence overactive bladder investigated using cyclic differential pulse voltammetry glassy carbon electrode electrooxidation hmt proceeds complex dependent process controlled potential electrolysis hmt solutions performed platinum gauze electrode aqueous methanolic media electrolyzed solutions analyzed using ultra performance liquid chromatography electrospray ionization quadrupole time flight mass spectrometry two main oxidation centers studied molecule located hydroxybenzyl alcohol group tertiary amino group oxidation first center proceeds several steps leading formation formyl tolterodine benzoquinone derivative several dimeric hydroxylated methoxylated products depending solution electrode potential second center oxidized preferentially alkaline media higher potentials hydrolytic cleavage diisopropylamine formation corresponding aldehydes mechanism electrochemical oxidation hmt proposed elsevier ltd rights reserved
applications involving digital control set admissible control actions finite quantized coupled state constraints fast dynamics explicit model predictive control empc provides attractive control formalism however design data driven empcs finite admissible control sets challenging relatively unexplored problem paper systematic data driven method proposed design quantized empcs empcs time varying output tracking nonlinear systems design involves sampling admissible state space using low discrepancy sequences provide scalability higher dimensional nonlinear systems sampled data point solving optimal quantized model predictive control actions determining feasibility intrinsic mixed integer nonlinear programming problem constructing empc control surface using multiclass support vector machines svms particular four widely used svm algorithms employed construct proposed data driven empc extensive testing comparison among different svm algorithms performed benchmark examples demonstrate effectiveness scalability proposed methodology
paper presents wearable inertial measurement system associated spatiotemporal gait analysis algorithm obtain quantitative measurements explore clinical indicators spatiotemporal gait patterns patients stroke parkinson disease wearable system composed microcontroller triaxial accelerometer triaxial gyroscope wireless transmission module spatiotemporal gait analysis algorithm consisting procedures inertial signal acquisition signal preprocessing gait phase detection ankle range motion estimation developed extracting gait features accelerations angular velocities order estimate accurate ankle range motion integrated accelerations angular velocities complementary filter reducing accumulation integration error inertial signals participants mounted system foot walk along straight line normal speed walking recordings collected validate effectiveness proposed system algorithm experimental results show proposed inertial measurement system designed spatiotemporal gait analysis algorithm promising tool automatically analyzing spatiotemporal gait information serving clinical indicators monitoring therapeutic efficacy diagnosis stroke parkinson disease
paper presents study tunisian electrical network multilateral mixed hvac hvdc interconnections first generic average model hvdc line developed parameters hvdc link power modulation controller determined tuned using graphical identification method strecj multilateral ties system studied via different study cases single bilateral trilateral interconnections configurations particular parallel interconnection tunisia libya simulated special emphasis given hvdc link italian transmission grid results confirm contribution hvdc transmission links improving tunisian network stability
background janus kinase jak inhibitors emerging promising new treatment modality many inflammatory conditions objective aim systematically review available data use jak inhibitors cutaneous diseases methods systematic review pubmed clinicaltrials gov results one hundred thirty four articles matched search terms original articles reports adverse events eighteen clinical trials found jak inhibitors extensively studied psoriasis showing beneficial results comparable effects achieved etanercept favorable results also observed alopecia areata promising preliminary results reported vitiligo dermatitis graft versus host disease cutaneous cell lymphoma lupus erythematosus common adverse events reported infections mostly nasopharyngitis upper respiratory tract infections limitations possible perform meta analysis results conclusions systematic review shows jak inhibitors hold promise many skin disorders still gaps regarding correct dosing safety profile medications dermatologic indications additional trials necessary address gaps
varying levels inter group contact affect voter preferences connection ethnically radical political candidates parties two competing hypotheses emerged last years first known group threat hypothesis argues voters ethnic religious group ethnically racially heterogeneous districts exhibit stronger preferences ethnically radical political candidates contact hypothesis argues groups living mixed localities actually less likely support ethnic radicals perspectives found empirical support previous study offered theoretical explanation two seemingly contradictory conclusions specify theory arguing effect district level integration conditioned direction group share national population test theory quantitatively using electoral data northern ireland
population potential child abuse offenders largely unstudied current study examine whether six component model used primary diabetes prevention could adapted child sexual abuse pre offenders whereby individuals prone sexual abuse yet committed offense prevented committing first offense six components include define track magnitude problem delineate well established risk factor profile risk persons identified define valid screening tests correctly rule disease rule without disease test effectiveness interventionsthe dunkelfeld project example produce disseminate reliable outcome data widespread application justified establish system continuous improvement using diabetes primary prevention model model number victims child sexual abuse might diminished
rapid progress high performance computing entails new challenges related solving large scientific problems various subject domains heterogeneous distributed computing environment network grid system cloud infrastructure specialists field parallel distributed computing give special attention scalability applications problem solving effective management scalable application heterogeneous distributed computing environment still non trivial issue control systems operate networks especially relate issue propose new approach multi agent management scalable applications heterogeneous computational network fundamentals approach integrated use conceptual programming simulation modeling network monitoring multi agent management service oriented programming developed special framework automation problem solving advantages proposed approach demonstrated parametric synthesis example static linear regulator complex dynamic systems benefits scalable application solving problem include automation multi agent control systems parallel mode various degrees detailed elaboration
alzheimer parkinson diseases share similar amyloidogenic mechanisms metal ions might play important role last neuropathy misfolding aggregation alpha synuclein alpha syn crucial pathological events moderate metal binding compound namely hydroxyquinoline carboxaldehyde isonicotinoyl hydrazone inhhq previously reported potential metal protein attenuating compound alzheimer treatment well tolerated healthy wistar rats alter major organ weights well tissues reduced glutathione biometal levels concentration inhhq definitively crosses blood brain barrier detected brain rats late intraperitoneal administration brain clearance complete inhhq able disrupt vitro anomalous copper alpha syn interactions mechanism probably involving metal ions sequestering compound non toxic human neuroglioma cells partially inhibits intracellular alpha syn oligomerization inhhq thus shows definite potential therapeutic agent parkinson well elsevier inc rights reserved
purpose among girls foster care become pregnant least age dworsky courtney youth risk foster care yfc report limited knowledge access use condoms ambivalent attitudes towards teen parenting participation risky behaviors current study adapted supplemented evidence based sexual health program called sihle using systematic adaptation framework adapt itt wingood diclemete address unique targeted needs youth living temporary shelter due lack housing youth study either foster care awaiting placement serious family problems risk entering foster care system methods thirty six youth participated sihle yfc stay temporary shelter four minute sessions focused increasing sexual health knowledge improving attitudes towards self efficacy condom use developing core skills problem solving communication results hypothesized youth showed high satisfaction intervention significant improvement sexual health knowledge pre post one month follow youth continued show significant improvement sexual health knowledge along significant reduction risky sexual behaviors though significant moderate effect sizes changes attitudes towards teen pregnancy condoms changes attitudes towards teen parenting conclusion taken together findings suggest sexual health education directly targeting unique needs yfc may improve sexual health knowledge behavior discussed context challenges associated intervention research population elsevier ltd rights reserved
paper model large area high efficiency interdigitated back contact ibc solar cell means distributed electrical network simulation tool allows accounting distributed resistive effects diffusions metallization model also considers electrical shading effect resistive losses due back surface field bsf emitter busbars calibrated model used investigate case large area ibc cell investigate influence key busbar parameters number busbars busbar width soldering pitch module connection metal sheet resistance predictive simulations allow finding optimum number busbars arising tradeoff electrical shading effect due bsf busbars resistive losses due emitter busbars fingers moreover show distance soldering points metal busbars influences choice busbar width found adequate number soldering points adopted busbar width kept lower hand adoption thick plating leads increase efficiency abs respect case sputtered metal thick
background little known regarding clinicians attitudes extent recommendation offer day insertions long acting reversible contraception larc applied practice study design since family planning agencies colorado iowa participated two initiatives reduce unintended pregnancy increasing larc provision clinic directors clinicians participating initiatives interviewed surveyed regarding larc provision practices attitudes results agencies required fewer visits contraceptive implant intrauterine device iud agencies typically offered iud typically offered implant one visit years experience professional title significantly predicted attitudes number visits required get larc discussion barriers must overcome full implementation professional larc guidelines women receive chosen methods without extra burden multiple visits elsevier inc rights reserved
objective climate particular sunshine influences mood energy levels creating positive upswing mood bright sunny days negative downswing cold dark winter seasons higher serotonin transporter availability healthy human subjects times lesser light exposure lower serotonin levels shown winter methods examined light dependent variations serotonin receptor binding limbic regions drug naive healthy human subjects receptor binding quantified using positron emission tomography radioligand carbonyl way binding potential values related amount individual exposure sunlight daily duration sunshine global radiation total light intensity results found lower serotonin receptor binding group exposed lower amount global light radiation partial correlation analysis revealed significant positive correlations regional postsynaptic serotonin receptor binding global radiation accumulated period days conclusions seasonal factors daily amount sunshine global radiation influence serotonin receptor binding limbic brain regions healthy human subjects combined recently demonstrated seasonal fluctuations serotonin transporter availability results underline importance seasonal factors regulation serotonergic transmission
paper presents power electronic converter used redistribute power among phases unbalanced power systems supposed designed based involved degree unbalance bidirectional converter chosen purpose whose modeling presented system solution considered part unified control system conventional active power filters may solely responsible compensating harmonics tuning passive filters becomes easier consequent reduction involved costs decentralized approach adopted control strategy implemented digital signal processor tmsf experimental results obtained experimental prototype rated kva properly discussed considering converter placed secondary side transformer supplying three distinct single phase loads effectively shown converter able balance currents transformer phases thus leading suppression neutral current
context prevention lower extremity sprain strain requires basis predicting individual athlete sustain injury unless modifiable risk factor addressed objective assess possible existence association reaction time measured completion computerized neurocognitive test battery subsequent occurrence lower extremity sprain strain design prospective cohort study setting preparticipation screening conducted computer laboratory day prior initiation preseason practice sessions participants ncaa division fcs football players main outcome measures lower extremity sprains strains sustained initiation preseason practice sessions end game season receiver operating characteristic analysis identified optimal reaction time cut point discrimination injured versus noninjured status stratified analyses performed evaluate differential influence reaction time injury incidence starters nonstarters results total lower extremity sprains strains sustained players reaction time cut point provided good discrimination injured noninjured cases sensitivity specificity relative risk odds ratio conclusions neurocognitive reaction time appears indicator elevated risk lower extremity sprains strains among college football players may modifiable performance exercises designed accelerate neurocognitive processing visual input
poor mental health concern world wide study examine effects socioeconomic environmental variables number days poor mental health reported across counties results suggest educational attainment employment opportunities including self employment social capital important benefits terms community mental health socio demographic variables also tend predicted effects amount sunshine january control seasonal affective disorder general conclusion study living non metro county adjacent metro core associated greater happiness mental health days also increase considerably due natural disasters affected regional climate variability policymakers concerned reducing average number poor mental health days across nation results suggest reducing poverty powerful strategy reducing income inequality
based monitoring data monitoring stations five key water quality indexes biochemical oxygen demand bod permanganate index codmn dissolved oxygen ammonium nitrogen total phosphorus selected analyze temporal spatial characteristics highly disturbed huaihe river basin via mann kendall trend analysis boxplot analysis temporal spatial variations water pollutant concentrations huaihe river basin investigated analyzed provide scientific basis water pollution control water environment protection ecological restoration results indicated yinghe river quanhe river honghe river guohe river baohe river seriously polluted rivers followed hongze lake luoma lake yishuhe river nansi lake bod codmn major pollution indexes monitoring stations reported water quality concentrations exceeded class level monitoring stations recorded significantly decreasing trends bod codmn respectively monitoring stations showed significantly increasing trend moreover water quality concentrations certain concentricity volatility according boxplot analysis monitoring stations majority monitoring stations recorded large fluctuation monitoring indexes indicated water quality concentrations unstable according seasonal variations water quality concentrations mainstream huaihe river monthly variation trends bod codmn concentrations basically consistent among seven monitoring stations bod codmn concentrations affected change stream discharge changes concentrations influenced regional environmental temperature concentrations decreased water temperature increased
novel controller proposed regulate link voltage single phase active power filter spapf proposed switched fractional controller sfc consists conventional controller fractional order controller decision maker switches commonly conventional controller used regulation loops due advantages steady state limited transient state hand controller overcomes drawbacks causes dramatic degradation control performances steady state fractional calculus theory approximation method used implement kind controller thus purpose paper switch controller steady state obtain best power quality switch controller external disturbances detected guarantee fast transient state investigate efficiency accuracy sfc considering robustness tests experimental setup established results sfc fulfill requirements confirm high performances steady transient states demonstrate feasibility effectiveness experiment results satisfied limit specified ieee harmonic standard
tensile response ultra high performance fibre reinforced cementitious composite uhpfrc placed given structural element strongly dependent final fibre distribution orientation respect stress direction present paper ndt method based magnetic properties steel fibres developed situ detection two quantities uhpfrc layers magnetic probe designed performing inductance measurements equations relating inductance fibre content orientation derived based analogy magnetic electrical circuits simplified physical model composite material performance method validated uhpfrc specimens produced varying matrix formulation fibre length fibre content orientation based theoretical formulation supported collected experimental evidence two reliable indicators fibre content orientation proposed require two inductance measurements zone relevance method quality control design uhpfrc highlighted elsevier ltd rights reserved
portrayal violence sex drugs alcohol media known adversely affect behavior children adolescents strong association perceptions media messages observed behavior especially children lately focus public health medical field media influences youth role pediatrician healthcare worker addressing area growing concern need explicitly explore influences media violence sex drubs alcohol youth within context social learning theory implications influences discussed recommendations pediatricians health care workers interact children adolescents described pediatricians health care workers incorporate media exposure probes developmental history patients become knowledgeable effects medial influences youth
aim present study compare effect three different kinds cling film including low density polyethylene ldpe film high density polyethylene hdpe film polyvinyl chloride pvc film pleurotus ostreatus fresh keeping condition simulated cold fresh supermarket shelf temperature humidity temperature around degrees storage environment relative humidity around results show cling film treatment keep better effect compared blank experiment compared ldpe film hdpe film pvc film reduce postharvest ostreatus weight loss maintaining high volume fraction low volume fraction packing first days storage ostreatus packaged hdpe film pvc film significant difference ostreatus packaged ldpe film days storage ostreatus packaged hdpe film pvc film sensory score significantly lower ostreatus packaged ldpe film respiration intensity ethylene production cell membrane permeability also significantly higher ostreatus packaged ldpe film condition ostreatus packaged ldpe fresh keeping effect best
wood contains large amount air even functional xylem air embolisms xylem affect water transport determine plant growth survival embolisms usually estimated laborious hydraulic methods prone several artefacts describe new method estimating embolisms based air flow measurements entire branches calculate amount air flowing branch vacuum applied cut bases branches different water potentials first investigated source air determining whether came inside outside branch second compared embolism curves according air flow hydraulic measurements vessel tracheid bearing species test hypothesis air flow related embolism air flow came almost exclusively air inside branch min measurements strongly related embolism propose new embolism measurement method simple effective rapid inexpensive allows several measurements branch thus opening new possibilities studying plant hydraulics
image feature representation hot topic computer vision field inspired weber law local graph structure lgs propose novel image feature representation descriptor called orthogonal symmetric local weber graph structure oslwgs contains two components differential excitation pattern dep orthogonal symmetric lgs oslgs particular dep extended bringing difference gaussian dog make oslwgs robust image noise addition oslgs overcome defects lgs including non symmetric single horizontal structure problems furthermore oslwgs histogram generated fusing dep oslgs improve discriminative power obtain precise image description encoded histogram classified via sparse representation extensive experiments feret cmupie lfw yale simulated yale partial occlusion rawfoot photex databases validate effectiveness proposed oslwgs experimental results demonstrate proposed algorithm efficient robust method compared state art approaches elsevier rights reserved
background cryptosporidium spp giardia duodenalis enterocytozoon bieneusi main causal pathogens gastrointestinal disease however limited reports prevalence organisms captive eurasian wild boars worldwide therefore examined occurrence identified species assemblages genotypes pathogens captive eurasian wild boars estimated zoonotic potential findings fecal samples collected captive eurasian wild boars china infected cryptosporidium duodenalis bieneusi infection rates significantly differed different areas differ wild boars kept indoors outdoors three fecal samples positive cryptosporidium duodenalis bieneusi respectively sequence analysis ssu rrna gene revealed cryptosporidium strains belonged scrofarum based sequence analysis agiardia gene duodenalis assemblages characterized fourteen bieneusi genotypes comprising five novel wildboar eight known ebpc chg chc pigebits rwsh genotypes identified sequencing ebpc frequent genotype detected specimens phylogenetic analysis revealed genotypes belonged group conclusions first report occurrence cryptosporidium duodenalis bieneusi captive wild boars china indicates presence zoonotic species assemblages genotypes poses threat public health findings suggest wild boars could significant source human infection water pollution
background hepatitis virus hcv infection important cause chronic liver disease affected world population studies shown adding sofosbuvir sof hcv polymerase inhibitor conventional therapy pegylated interferon pegifn plus ribavirin rbv increase rate sustained virologic response svr among hcv infected patients study conducted determine effect combination therapy pegifn rbv plus sof chronic hepatitis genotype infection using systematic review meta analysis methods study electronic databases including pubmed scopus science direct web science comprehensively searched using appropriate strategies containing related keywords hepatitis pegifn rbv sof studies assessed efficacy combination therapy pegifn rbv plus sof chronic hepatitis genotype infection included meta analysis results screening records included five articles total sample size meta analysis based fixed effect model pooled svr rate treatment regimen pegifn rbv plus sof calculated conclusions combination therapy pegifn rbv plus sof results high treatment response patients hcv genotype infection
study designed investigate effects two instructional approaches versus conventional learners knowledge acquisition learning transfer electrical circuits content physics participants graders secondary school lisbon years participants divided two groups experimental group constituted three intact classes control group constituted two intact classes experimental group taught using digital learning environment designed model principles control group learned contents conventional method assessed students performance knowledge acquisition transfer perceived cognitive load instructional efficiency results indicated experimental group performed significantly better control group knowledge acquisition test learning transfer test also perceived less cognitive load transfer test learning environment developed model proved instructional efficient conventional method
article deals issue connecting modules modular structures applied robotics manufacturing engineering technology general joining motion module implemented interconnecting interfaces placed stringent requirements strength stiffness weight possibility transporting energy data flow interface market founds similar solutions however solutions mostly designed output stages industrial robots primarily solutions focus end effector exchange systems robotics determine total track modular machine necessary design new model connecting interface meets requirements placed
intelligent tutoring personalization considered two important factors research learning systems environments effective tool used improve problem solving ability intelligent tutoring system capable mimicking human tutor actions implementing one one personalized adaptive teaching paper novel flowchart based intelligent tutoring system fits proposed benefiting bayesian networks process decision making aid students problem solving activities learning computer programming fits takes full advantage bayesian networks also benefits multi agent system using automatic text flowchart conversion approach engaging novice programmers flowchart development aim improving problem solving skills end order investigate efficacy fits problem solving ability acquisition quasi experimental design adopted research according results students fits group experienced better improvement problem solving abilities control group moreover regard improvement user problem solving ability fits shown considerably effective students different levels prior knowledge especially lower level prior knowledge
separation sugar isomers extracted biological samples challenging natural occurrence alpha beta anomers case hexoses pyranose furanose forms reductive amination method developed tagging sugars aim becoming part metabolomics work flow best separation common hexoses glucose fructose mannose galactose achieved aniline used tagging reagent combination separation zichilic column method used tag range sugars including pentoses uronic acids method simple perform able improve separation sugars response electrospray ionisation method applied profiling sugars urine number hexose pentose isomers could observed also applied quantification sugars post mortem brain samples three control samples three samples individuals suffered bipolar disorder
loss dopaminergic neurons leads parkinson disease however mechanism vulnerability neurons fully understood demonstrate trpc regulates type channel contributes rhythmic activity adult neurons substantia nigra region store depletion activates trpc via stim inhibits frequency amplitude rhythmic activity neurons wild type trpc mice similarly trpc substantia nigra neurons showed increased type currents decreased stimulation dependent stim interaction decreased neurons type currents open channel probability channels also reduced upon trpc activation whereas increased currents observed upon stim trpc silencing increased interaction trpc stim observed upon store depletion loss either trpc stim led cell death prevented inhibiting type channels neurotoxins mimic parkinson disease increased function decreased trpc expression inhibited mediated stim interaction induced caspase activation importantly restoration trpc expression inhibited function increased cell survival together provide evidence trpc suppresses activity providing stim based scaffold essential neuron survival
alzheimer disease irreversible highly progressive neurodegenerative disease clinically patients display impairments episodic spatial memory however underlying neuronal dysfunctions result impairments remain poorly understood hippocampus crucial spatial episodic memory thus tested hypothesis abnormal neuronal representations space hippocampus contribute memory deficits test hypothesis recorded spikes place cells hippocampal subfield together corresponding rhythmic activity local field potentials xtg mouse model observed disturbances place cell firing patterns many consistent place cell disturbances reported rodent models found place cell representations space unstable xtg mice compared control mice furthermore coordination place cell firing hippocampal rhythms disrupted xtg mice specifically smaller proportion place cells xtg mice significantly phase locked theta slow gamma rhythms theta slow gamma phases spikes occurred also altered remarkably disturbances observed age detectable pathology developed consistencies findings xtg mice previous findings models suggest disturbances place cell firing hippocampal rhythms related rather reflecting peculiarities inherent particular transgenic model thus disturbed rhythmic organization place cell activity may contribute unstable spatial representations related spatial memory deficits wiley periodicals inc
background addressing children tobacco smoke exposure tse remains public health priority however low uptake ineffectiveness treatment particularly low income populations face numerous challenges smoking behavior change multilevel intervention combining system level health messaging advice tse delivered community clinics disseminate special supplemental nutrition program women infants children wic combined nicotine replacement intensive multimodal individual level behavioral intervention may improve tse control efforts high risk populations methods design trial uses randomized two group design three measurement points baseline month month follow primary outcome bioverified child tse secondary outcome bioverified maternal quit status smoking mothers children less years old recruited wic clinics participants receive wic system level intervention based ask advise refer aar best practices guidelines pediatrics clinics includes training wic staff importance maternal tobacco control detailing clinics aar intervention prompts routine work flow remind wic nutrition counselors ask mothers child tse advise tse harms benefits protection refer smokers cessation services receiving system intervention mothers randomized receive months additional treatment attention control intervention multimodal behavioral intervention mbi treatment includes telephone counseling sessions child tse reduction smoking cessation provision nicotine replacement therapy mobile app support cessation efforts multimedia text messages tse smoking cessation attention control intervention offers equivalent contact mbi includes nutrition focused telephone counseling mobile app multimedia text messages improving nutrition control condition also receives referral state smoking cessation quitline discussion study tests innovative community based multilevel integrated multimodal approach reducing child tse vulnerable low income population approach sustainable potential wide reach wic integrate tobacco intervention prompts routine workflow refer smokers free evidence based behavioral counseling interventions state quitlines
developed pilot tested first online psycho educational intervention specifically targets people family history depression links links provides genetic risk information evidence rated information preventive strategies depression incorporates risk assessment tool several videos using professional actors links pilot tested general practitioner setting patient sample included people family history least one first degree relative fdr major depressive disorder mdd bipolar disorder patients attending participating practices invited enroll study letter patients self identified least one first degree relative fdr mdd eligible patients completed questionnaires pre post viewing links measures assessing satisfaction relevance emotional impact perceived improvement understanding six practices participated patients completed questionnaires reported satisfied satisfied links reported links met expectations exceeded expectations links judged highly acceptable sample attendees results indicate assessment effectiveness larger controlled trial warranted
parkinson disease progressive neurodegenerative disorder development disease modifying treatment still unmet medical need considering implication free iron report design characterization novel hybrid iron chelator multitarget directed ligand binding functional assays dopamine receptors indicate potent agonist activity molecule displayed efficient preferential iron chelation properties along poient vivo activity reserpinized animal model compound also rescued cells toxicity induced iron delivered intracellularly dose dependent manner however selective dopamine agonist well known antiparkinsonian drug pramipexole produced little neuroprotection effect experimental condition observations strongly suggest promising multifunctional lead molecule viable symptomatic disease modifying therapy
background radiographic sacroiliitis hallmark ankylosing spondylitis detection acute sacroiliitis pivotal early diagnosis although radiographic sacroiliitis distinguishing feature sacroiliitis seen variety disease entities case presentation present interesting case sacroiliitis patient paget disease patient presented inflammatory back pain treated bisphosphonate case demonstrates comorbidity paget disease possible ankylosing spondylitis also present review literature cases paget involvement sacroiliac joint conclusions addition review radiographic changes sacroiliac joint classical ankylosing spondylitis well common diseases compare contrast features diseases mimic sacroiliitis pelvic radiograph including paget disease osteitis condensans ilii diffuse idiopathic skeletal hyperostosis infections sarcoid sacroiliitis features pelvic radiographic findings help distinguish among mimics however one must also rely heavily extra pelvic radiographic lesions addition clinical presentation various nuances may incline clinician correct diagnosis rheumatologists familiar imaging differences among diseases classic spondylitis findings
paper deals iterative formation control problems multi agent systems switching topologies approach combines consensus protocol algorithms conducted iterative learning control update leads networks dynamically changing evolution along two directions finite time axis infinite iteration axis distributed algorithm constructed based nearest neighbor information convergence established via roesser system based two dimensional approach shown desired relative formation agents achieved along finite time trajectory union interaction graphs agents iteration intervals finite length spanning tree every time step simulations included illustrate effectiveness derived results
combined oral contraceptives coc believed cause many effects desired ones use birth control method speculative ones weight gain present designed research focusing possible link coc recognition facial expressions emotions study examined women including users coc non users examine possible effect coc usage accuracy speed recognition facial expressions emotion control intervening variables included research design used hierarchical regression model statistical analysis proved effect coc usage recognition facial expressions emotions
design variable gain amplifier vga based fully differential operational amplifier presented proposed vga topology verified simulations analysis main circuit parameters vga designed cmos technology using cadence environment bsim family models designed circuit works power supply simulation results show gain bandwidth gbw mhz capacitive load total harmonic distortion less input amplitude achieved implemented feedback circuit stable according phase margin degrees
omitted citations missing links cited paper corresponding citing papers main consequence several bibliometric database errors paper investigates possible relationship omitted citations publishers relevant citing papers relationship potentially meaningful publishers generally impose editorial styles could affect database errors publishers may efficient others detecting correcting pre existing errors manuscripts published reducing risk database errors based extensive sample scientific papers manufacturing engineering field study examines citations omitted scopus wos databases using recent automated algorithm major results significant differences terms omitted citation rate publishers omitted citation rates publishers may vary depending database use elsevier ltd rights reserved
intrinsic image decomposition important topic computer vision computer graphics applications however challenging problem adopting information single image therefore additional priors supplementary information multiply images user interactions necessary address problem paper propose novel scheme use multiple images intrinsic image decomposition based similar strategy robust principal component analysis rpca rpca utilizes fact reflectance layer common multiple lights scene attempts decompose data matrix constructed input images low rank matrix sparse matrix possible sparse matrix sufficiently sparse often case computer vision applications moreover weighting parameter low rank sparse matrices greatly affects accuracy results tuning parameter tricky paper proposes rank constrained pca algorithm rcpca solving background recovering problems fixing rank low rank matrix allows rcpca better recover low rank matrix data matrix comprehensive tests show rcpca produces stable accurate results
distributed computing gives backing buyers diminish inner foundation suppliers expand incomes utilizing particular framework proper load balancing dynamic resource provisioning improves cloud performance attracts cloud users paper propose automated resource provisioning algorithm speculation resource provisioning prompting load balancing speculative approach resource provisioning attempt quantify resource allocation use two level adaptive prediction mechanism check computational patterns past resource allocation future requirement framework guarantees suitable resources required application dodging provisioning resource supports energy efficiency resource allocation use estimation methodology address variability historical data balance speculation overhead conveyed proposed work open source cloud structure contrasted outcomes machine learning approaches experimental results demonstrate adaptive resource allocation customer driven service management rapidly changing requirements cloud computing
world wide web evolved gradually document delivery platform architecture distributed programming largely unplanned evolution apparent set interconnected languages protocols web application must manage paper presents web domain specific statically typed functional programming language much simpler model programming modern web applications web model unified programs single programming language compiled web standards languages needed supports novel kinds encapsulation web specific state exposes simple concurrency programmers reason distributed multithreaded applications via mix transactions cooperative preemption give tutorial introduction main features web discuss language implementation production web applications use
background food addiction model proposes obesity overlaps addiction terms neurobiological alterations striatum related clinical manifestations craving persistence unhealthy habits therefore aimed examine functional connectivity striatum excess weight versus normal weight subjects determine extent association striatum connectivity individual differences food craving changes body mass index bmi methods forty two excess weight participants bmi normal weight participants enrolled study functional connectivity ventral dorsal striatum indicated seed based analyses restingstate data food craving indicated subjective ratings visual cues high calorie food changes bmi baseline weeks follow assessed excess weight participants measures connectivity ventral striatum dorsal striatum compared groups correlated craving bmi change results participants excess weight displayed increased functional connectivity ventral striatum medial prefrontal parietal cortices dorsal striatum somatosensory cortex dorsal striatum connectivity correlated food craving predicted bmi gains conclusions obesity linked alterations functional connectivity dorsal striatal networks relevant food craving weight gain neural alterations associated habit learning thus compatible food addiction model obesity
paper propose develop story generator hints using machine learning approach learning phase system fed stories pos tagged converted language relationship model represented conceptual graph synthesis phase input hints delimited using hyphen converted conceptual graph graph matched conceptual graph corpus probable words sequences along relationship determined using three proposed methods namely randomized selection weighted selection using bigram probability hint phrases weighted selection using product bigram probability conceptual graph bigram probability hint phrases using words sequences relationships sentence assembler algorithm designed position words form sentence make story complete readable suffixes added using tamil grammar assembled words story generated syntactically semantically correct
continuous apomorphine infusion apo one treatments available advanced parkinson disease years treated patients apo mean age average evolution time apo onset years mean duration treatment months june remained medication active group stopped active group mean age recruitment mean evolution years main indication apo lack deep brain stimulation criteria dbs twelve patients waiting list dbs average time since apo onset months active group apo decreased state allowed reducing levodopa dopamine agonists dyskinesia balance worsen cognitive decline change within first months hallucinations within first months presence subcutaneous nodules frequent adverse event group main reason discontinuation side effects psychosis common within first year patients stopped apo eighteen patients eventually got dbs apo good option advanced since permits significant reduction time antiparkinsonian drugs effect sustained time treated patients year dyskinesia seems worsen combining apo dbs simultaneously alternatively provides good results
tracking accuracy plays critical role vehicle vehicle communications based active safety applications paper proposed beacon rate control algorithm reduce tracking error analyzing vehicle trajectory tracking process found tracking error proportional moving status vehicle well data delay due constraint wireless communication capacity data delay nodes shortened infinitely principle algorithm design shorten data delay increasing beacon rate vehicles higher dynamics due reason vehicles prone cause larger tracking error data delay simulation results show using proposed algorithm beacon rate subject vehicle adapt vehicle dynamics thus way tracking error controlled decimeter level
support methyl aspartate receptor nmdar hypofunction hypothesis schizophrenia led increasing focus restoring proper glutamatergic signaling approach treatment devastating disease ability metabotropic glutamate mglu receptors modulate glutamatergic neurotransmission thus attracted considerable attention development novel antipsychotics consisting eight subtypes classified three groups based sequence homology signal transduction pharmacology mglu receptors provide wide range targets modulate nmdar function well glutamate release recently allosteric modulators mglu receptors developed allow unprecedented selectivity among subtypes groups facilitating investigation effects subtype specific modulation preclinical animal models positive allosteric modulators pams group mglu receptor mglu efficacy across three symptom domains schizophrenia positive negative cognitive discovery development mglu pams display unique signal bias suggests efficacy retained avoiding neurotoxic effects earlier compounds interestingly mglu negative allosteric modulators nams appear efficacious positive symptom models disease still early preclinical development selective group mglu receptor mglu agonists reached clinical trials unsuccessful specific mglu mglu receptor targeting still hold great promise genetic studies implicated mglu antipsychotic effects group agonists mglu pams since entered clinical trials additionally mglu appears play important role cognition may confer neuroprotective effects thus promising target alleviate cognitive deficits schizophrenia although group iii mglu receptors mglu attracted less attention mglu agonists pams appear efficacy across three symptoms domains preclinical models recent discovery heterodimers comprising mglu mglu may explain efficacy mglu selective compounds remains determined taken together compounds targeting mglu receptors specifically subtype selective allosteric modulators provide compelling alternative approach fill unmet clinical needs patients schizophrenia
complement system homeostasis important host self protection anti microbial immune surveillance recent research indicates roles tissue development remodelling complement also appears several points interaction blood coagulation system deficiency altered function due gene mutations polymorphisms complement effectors regulators including factor associated familial sporadic autoimmune inflammatory thrombotic disorders autoantibodies play part include systemic lupus erythematosus rheumatoid arthritis atypical haemolytic uremic syndrome anti phospholipid syndrome age related macular degeneration diseases generally complex multigenic heterogeneous symptoms predisposition susceptibility usually need triggered vascular trauma drugs infection non complement genetic factors also play part underlying events seem include decline peripheral regulatory cells dendritic cell cell tolerance associated alterations lymphoid organ microenvironment factor abundant protein synthesised many cell types reported binding many different ligands even high affinity may influence large number molecular interactions together accepted role factor within complement system factor involved mesenchymal stem cell mediated tolerance also contributes toself tolerance augmenting icb production opsonisation apoptotic cells silent dendritic cell engulfment via complement receptor mediates anti inflammatory tolerogenic effects apoptotic cell context may operation phagocytic receptors complement receptors tim glycoprotein family specifically bind phosphatidylserine expressed apoptotic cell surface factor able discriminate self nonself surfaces self protection anti microbe defence factor particularly abundant platelet protein may also modulate blood coagulation anti thrombotic role review number interaction pathways coagulation immunity together associated diseases indicate factor may expected exert influence based reports diversity ligands factor elsevier ltd rights reserved
summary elderly patients hip osteoarthritis aged acetabular dysplasia parameters decreased sharp angle acetabular roof obliquity angle acetabular head index incidence atrophic type increased vertebral body fracture frequent atrophic type suggesting involvement osteoporosis onset hip osteoarthritis introduction osteoarthritis associated increased bone formation local site however excessive bone resorption also found occur early stages osteoporosis may involved onset elderly patients conducted cross sectional radiographic study patients hip examined association age factors acetabular dysplasia sharp angle acetabular roof obliquity angle acetabular head index well osteoblastic response determine potential involvement osteoporosis methods study included patients men women undergone total hip arthroplasty diagnosis hip measured parameters acetabular dysplasia using preoperative frontal ray images evaluated patient according bombelli classification hypertrophic normotrophic atrophic type results patients aged parameters acetabular dysplasia decreased incidence atrophic type significantly higher older patients vertebral body fractures frequent atrophic type types additionally index acetabular dysplasia lower atrophic type contrast hypertrophic type present relatively younger patients associated increased index acetabular dysplasia conclusion elderly patients hip parameters acetabular dysplasia decreased incidence atrophic type increased patients aged frequency vertebral body fracture high patients atrophic type suggesting involvement osteoporosis onset hip
cognitive assessment interview cai interview based instrument assess cognition considering impact cognitive impairment daily activities aimed explore associations spanish version cai cai neuropsychological battery measure psychosocial functioning psychosis sample consisted fifty six first episode psychosis fep patients non fep patients assessed neuropsychological battery cai short disability schedule das patients also underwent clinical assessment additionally controls assessed neuropsychological battery cai normalization purposes results showed cai scores overall correlated neuropsychological battery non fep patients fep patients found fewer significant correlations associations maintained controlling clinical symptoms cai rater scores contributed variance das scores groups negative disorganized symptoms cai may good instrument assess cognition non fep patients fep patients less effective capturing cognitive impairments functional consequences probably cognitive deficits yet become evident due recency illness onset functional disturbances observed due cognitive impairments elsevier rights reserved
first two companion papers describing concepts techniques mentalization based approach understanding managing family violence review evidence attachment difficulties sudden high levels arousal poor affect control contribute loss mentalizing capacity turn undermines social learning favor transgenerational transmission violent interaction patterns suggested physically violent acts possible mentalizing temporarily inhibited decoupled however mentalized context attachment relationships family generates epistemic trust within family unit reduces likelihood family violence implications framework therapeutic work families discussed
although men type diabetes frequently lowered testosterone levels well established whether ascribable diabetic state per factors obesity objective determine prevalence correlates low testosterone middle aged men diabetes conducted cross sectional study men including men type diabetes men men without diabetes prevalence total testosterone nmol low occurring none men men men without diabetes men higher testosterone levels compared men without diabetes even adjustment body mass index bmi age men lower testosterone compared controls longer significant bmi age taken account entire cohort remained inversely associated bmi independent age sex hormone binding globulin diabetic status whereas calculated free testosterone cft independently inversely associated age bmi results suggest marked reductions circulating testosterone uncommon middle aged men diabetes increasing bmi age dominant drivers lowered total cft respectively independent presence absence diabetes
numerical analysis reciprocating hydraulic rod seal textured rod performed sealed pressure instroke elevated outstroke atmospheric analysis consists coupled fluid mechanics contact mechanics load support analyses takes account starvation fluid transport friction force film thickness distribution contact pressure distribution fluid pressure distribution sealing zone computed polyurethane cup seal starvation instroke dominates seal behavior moderate high rod speeds results indicate friction force exerted rod seal significantly reduced texturing rod could even slightly increased elsevier ltd rights reserved
paper accepts widespread view electricity generation systems transition towards greater proportion renewables provision increasing need storage facilities however differs studies contrasting private incentives storage operator public desirability bulk storage key factor context market britain renewable energy largely means wind generation nature wind generation problem wind high variance intermittent nature explored argued missing money missing market issue providing secure energy supplies also missing informational issue key opportunity new storage participation capacity market setting right
chromomycosis fungal infection affects epidermis dermis subcutaneous tissue caused dematiaceous fungal species turn black staining report case year old male patient rural worker treated without success three decades facial lesions progressed caused severe cicatricial retraction infection evolved left upper eyelid developed cicatricial ectropion surgical treatment performed using skin obtained patient abdomen patient developed good postoperative appearance
paper explores relationship education parenting family prism particularities family learning family learning example educational initiative primarily aimed parents linked wider policy concerns explored mapping social geographies family learning played across productive different sites spaces identities based qualitative research undertaken west london paper draws individual group interviews mothers participating family learning classes interviews family learning providers key argument extend focusing social geographies family learning home school work community nation allows see educational initiatives extend state reach family life producing particular normative versions family good parenting operating range interconnecting scales education remains cornerstone family policy detailed analyses specific initiatives point implementation practiced received vital better understanding diverse varied effects contemporary society
amount internet traffic increasing substantially measuring per flow traffic accurately important task nature high speed routers measurement algorithm fast enough process every packet going executable limited amount memory well paper use two techniques solve memory speed constraints recycling memory block resetting memory constraint confinement virtual vectors one word speed constraint techniques allow measurement algorithm called recyclable counter confinement rcc accurately measure individual flow sizes small amount memory terms encoding speed uses one memory access one hash computation unlike previously proposed schemes rcc decodes quickly demanding three memory accesses two hash calculations fast decoding enables real time detection high uploader downloader finally rcc data structure includes flow labels large flows possible quickly retrieve list large flow names sizes
present review reader led relevant observations prompted oncologists haematologist consider fdg pet new paradigm management clinical practice role functional imaging lymphoma staging restaging prognostication metabolic tumour volume computing reviewed detail moreover special focus addressed technical practical aspects pet scan reporting set last decade ensure reproducibility therapeutic results finally predictive role pet long term treatment outcome compared another well known prognosticator minimal residual disease mrd detection immunoglobulin gene rearrangement assessment
background acute kidney injury aki increasingly recognised ageing populations paucity data aki risk factors among older individuals diabetes infections particularly high risk aki objective study evaluate risk factors developing acute kidney injury aki amongst older patients diabetes community acquired pneumonia cap england whether impact underlying kidney function varied age methods population based retrospective cohort study years using electronic health records clinical practice research datalink linked hospital episode statistics study population comprised individuals diabetes aged years cap associations demographic lifestyle factors morbidities medications development aki within days cap explored logistic regression model results among patients cap complete covariate data patients developed subsequent aki multivariable analyses factors found independently associated aki included male sex adjusted odds ratio aor confidence interval hypertension aor prescribed either angiotensin converting enzyme inhibitors angiotensin receptor blockers aor insulin aor presence proteinuria aor low estimated glomerular filtration rate egfr odds aki graded amongst older participants aged years compared younger age egfr min min aor egfr min whilst egfr min associated approximately fold increase odds aki amongst younger individuals value interaction conclusions identified risk factors help primary care hospital providers identify high risk patients need urgent management including intensive monitoring prevention aki following pneumonia
explored epidemiology outcomes clostridium difficile infection cdi recurrence among medicare patients nursing home whose cdi originated acute care hospitals conducted retrospective population based matched cohort combining medicare claims minimum data set including hospitalized patients age years transferred hospitalization cdi incident cdi defined icd code others prior days cdi recurrence defined within days last day cdi treatment oral metronidazole oral vancomycin fidaxomicin days part file icd code cdi rehospitalization cox proportional hazards linear models adjusted age gender race comorbidities examined mortality within days excess hospital days costs patients recurrent cdi compared without among survivors index cdi hospitalization discharged suffered recurrence demographics clinical characteristics baseline similar risk death without median number hospitalizations iqr among iqr among without recurrence adjusted excess hospital days per patient medicare reimbursements group recurrence although recurrent cdi increase risk death associated far higher risk rehospitalization excess hospital days costs medicare
although breast cancer becoming prevalent africa epidemiologic studies undertaken appropriate methodologic approaches remain uncertain therefore conducted population based case control study accra kumasi ghana enrolling women lesions suspicious breast cancer population controls biopsy tissue cases prior neoadjuvant therapy given blood saliva fecal samples sought study subjects response rates risk factor prevalences odds ratios established breast cancer risk factors calculated total recruited cases diagnosed malignancies benign conditions indeterminate diagnoses response rates interviews cases controls vast majority interviewed subjects providing saliva cases controls blood samples lower proportions provided fecal samples risk factor prevalences unique compared women countries less education higher parity cancer risk factors resembled patterns identified elsewhere elevated risks associated higher levels education familial histories breast cancer low parity larger body sizes subjects benign conditions younger exhibited higher socioeconomic profiles higher education lower parity malignancies suggesting selective referral influences defining breast cancer risk factors africa study showed successful population based interdisciplinary studies cancer africa possible require close attention diagnostic referral biases standardized documented approaches high quality data collection including biospecimens new breast cancer incidence rising rapidly throughout africa epidemiologic molecular studies undertaken best practices study design yet established study authors discuss factors recruitment data collection biological sample collection found prevalence various risk factors differed magnitudes associations similar observed elsewhere methods results indicate successful studies africa possible despite many challenges
positivity asymptotic stability time varying discrete time continuous time linear systems electrical circuits addressed necessary sufficient conditions positivity time varying linear systems electrical circuits established using extension positive fractional systems lyapunov method asymptotic stability positive systems electrical circuits shown conditions positivity descriptor time varying discrete time linear systems established examples positive asymptotically stable systems electrical circuits presented
rapid progress urbanization china important event affect economic social development china world development low carbon eco city study low carbon eco city development strategy determine development low carbon eco city follow city function low carbon eco city development rational development city industry scientific planning reasonable guide development low carbon eco city planning improve index system implementation planning eia ensure sustainable development city time sustainable transportation system comprehensive guidance city energy efficient operation construction sustainable city traffic system research energy saving technology promotion promotion green building technology clean production technology provide technical support development low carbon eco city promote system innovation reform taxation system evaluation system create system environment development low carbon eco city reform administrative management system city government city government function transformation optimization promote development low carbon eco city
persistent hyperglycemia impairment redox status establishment inflammatory pathophysiology integrally play important role pathogenesis diabetic cardiomyopathy present study examined therapeutic potential protocatechuic acid isolated sansevieria roxburghiana rhizomes employing rodent model type diabetes induced high fat diet low single dose streptozotocin rats exhibited significantly high fasting blood glucose level alteration serum lipid profile increased levels lactate dehydrogenase creatine kinase sera rats revealed occurrence hyperlipidemia diabetic pathophysiology significantly high levels serum reactive protein pro inflammatory mediators revealed establishment inflammatory occurrence rats besides significantly high levels troponins sera revealed establishment cardiac dysfunctions rats however protocatechuic acid treatment could significantly reverse changes serum biochemical parameters related cardiac dysfunctions molecular mechanism studies demonstrated impairment signaling cascade irs pik akt ampk glut glucose metabolism skeletal muscle rats significant activation polyol pathway enhanced production ages oxidative stress regulation inflammatory signaling cascades pkc parp observed myocardial tissue rats however protocatechuic acid treatment could significantly stimulate glucose metabolism skeletal muscle regulated glycemic lipid status reduced secretion pro inflammatory cytokines restored myocardial physiology rats near normalcy histological assessments also agreement findings silico molecular docking study supported interactions protocatechuic acid different signaling molecules pik irs akt ampk pkc parp involved glucose utilization inflammatory pathophysiology silico adme study predicted protocatechuic acid would support drug likeness character combining results would suggest possibility protocatechuic acid new therapeutic agent future
study presents integrated approach targeting critical source areas csas control nonpoint source pollution watersheds csas intersections hydrologically sensitive areas hsas high pollution producing areas watersheds hsas areas high hydrological sensitivity potential generating runoff based soil topographic index consistence saturation excess runoff process high pollution producing areas areas high potential generating pollutants areas based simulated pollution loads streams soil water assessment tool integrated approach applied neshanic river watershed suburban watershed mixed land uses new jersey results show several land uses result water pollution agricultural land causes sediment nitrogen phosphorus pollution wetlands cause sediment phosphorus pollution urban lands cause nitrogen phosphorus pollution primary csas agricultural lands three pollutants urban lands nitrogen phosphorus wetlands sediment phosphorus pollution producing areas classified csas located hsas pollutants generated areas less likely transported runoff streams integrated approach identifies csas fine scale useful targeting implementation best management practices water quality improvement applied broadly different watersheds improve economic efficiency controlling nonpoint source pollution
alcohol consumption cognitive impairment frequently occur propose relationship familiar exposure alcohol cues primes expectations cognitive impairment across five studies find absence evidence reduced cognitive performance people hold alcoholic beverage perceived less intelligent mistake term imbibing idiot bias fact merely priming observers alcohol cues causes judge targets hold beverage less intelligent bias driven belief less intelligent people likely consume alcohol find bias may costly professional settings job candidates ordered wine interview held dinner viewed less intelligent less hireable candidates ordered soda however prospective candidates believe ordering wine rather soda help appear intelligent society consumer psychology published elsevier inc rights reserved
oxidative stress mainly contributed reactive oxygen species ros implicated pathogenesis several diseases review two primary examples fibrosis cancer fibrosis ros promote activation proliferation fibroblasts myofibroblasts activating tgf beta pathway autocrine manner cancer ros account genomic instability resistance apoptosis proliferation angiogenesis importantly ros trigger cancer cell invasion invadopodia formation well extravasation distant metastasis site use antioxidant supplements enzymes inhibitors ros generating nadph oxidases nox logical therapeutic intervention fibrosis cancer review attempts progress challenges lastly review nanoparticles inherent antioxidant activity also promising therapeutic option considering additional feature delivery platform drugs genes imaging agents
systematic review aims identify evidences distortions time perception people impulsivity disorders conditions impulsivity traits namely traumatic brain injuries certain personality disorders addictive behavior disorders pathological gambling studies related deficits impulsivity disorders retrieved multiple literature databases predefined inclusion exclusion criteria obtained documents selected analysis final set studies retrieved review regardless conflicting findings available results suggest patients orbitofrontal lesions produce reproduce significantly less time estimate time periods significantly longer healthy subjects patients borderline personality disorder show decreased time perception patients antisocial personality disorder seem execute premature responses time estimation tasks stimulant dependent individuals also tend overestimate time intervals pathological gamblers demonstrate shorter time horizons social gamblers taken together available data suggest impulsive individuals tend overestimate passage time execute premature responses producing reproducing less time research necessary increase strength evidences issue systematic review updates evidences distortions impulsivity improving understanding relations two variables elsevier ltd rights reserved
notion universal construction suited distributed computing introduced herlihy celebrated paper wait free synchronization acm trans program lang syst universal construction algorithm used wait free implement object defined sequential specification herlihy paper shows basic system model supports atomic read write registers enriched consensus objects allow design universal constructions generalized notion universal construction recently introduced gafni guerraoui proceedings international conference concurrency theory concur springer lncs universal construction algorithm used simultaneously implement objects instead one object guarantee least one constructed objects progresses forever herlihy universal construction relies atomic registers consensus objects universal construction relies atomic registers simultaneous consensus objects wait free equivalent set agreement objects read write system model paper significantly extends universality results introduced herlihy gafni guerraoui particular present universal construction satisfies following five desired properties satisfied previous universal construction among objects constructed least objects one guaranteed progress forever progress condition processes wait freedom means correct process executes infinite number operations object progresses forever constructed objects stops progressing copies one process stop state proposed construction contention aware sense uses read write registers absence contention generous respect obstruction freedom progress condition means process able complete one pending operations objects processes hold still long enough proposed construction based new design principles called universal construction uses natural extension simultaneous consensus objects called simultaneous consensus objects together atomic registers objects shown necessary sufficient building universal construction sense objects
report developed scalable approach massive synthesis hexagonal turbostratic composite boron nitride nanosheets bnnss strikingly effective reliable high throughput grams synthesis performed via facile chemical foaming process degrees utilizing ammonia borane precursor characterization results demonstrate high quality bnnss lateral size tens micrometers thickness tens nanometers obtained growth mechanism bnnss also discussed based thermogravimetric analysis clearly shows two step weight loss bnnss used making thermoconductive bnnss epoxy resin composites thermal conductivity composites obviously improved due introduction bnnss consideration unique properties boron nitride novel bnnss envisaged valuable future high performance polymer based material fabrication elsevier ltd rights reserved
accurate determination compressive tensile strength limestone important subject design geotechnical structures although several classical approaches literature strength prediction predictive accuracy generally satisfactory trend literature apply artificial intelligence based soft computing techniques complex prediction problems artificial neural networks member soft computing techniques applied strength prediction several types rocks literature considerable success although artificial neural networks successful prediction inability explicitly produce prediction equations create difficulty practical circumstances another member soft computing family known genetic programming useful candidate overcome problem genetic programming based approaches yet applied strength prediction limestone paper makes attempt apply promising set genetic programming techniques known multi expression programming mep gene expression programming gep linear genetic programming lgp uniaxial compressive strength ucs tensile strength prediction chalky clayey soft limestone data strength prediction generated experimentally university gaziantep civil engineering laboratories using limestone samples collected gaziantep region turkey elsevier ltd rights reserved
pool tag scanning process commonly used memory analysis order locate kernel object allocations enabling investigators discover evidence artifacts may freed otherwise maliciously hidden operating system fastest current scanning techniques require exhaustive search physical memory process linear time complexity physical memory size propose novel technique calling pool tag quick scanning able reduce scanning space orders magnitude resulting much faster discovery targeted kernel data structures maintaining high degree accuracy authors published elsevier ltd behalf dfrws
paper presents field measurements dye solute injected coastal sand investigate contaminant advection intertidal beach sand measurements show pathways contaminated plume unsaturated zone flood ebb tides prescribed amount dye tracer solution directly injected topsoil average porosity predetermined locations river mersey outer estuarial beach ebb tide injected dye monitored sampled photographed several tidal cycles distinctive features plume full two dimensional cross sections sediments water table depth sampled situ close injection point differing previous contaminant monitoring tests aquifers advective movement attributed tidal impact different contaminant transport aquifers experimental results show plumes significantly large spatial variability diverging upwards converging downwards conical geometric shape different usual spherical elliptical shape reported literature mean vertical motion plume reaches three times top width within ten tidal cycles exceeding narrow bottom width factor order observed transport features plume within beach sand significant relevance saltwater intrusion surface water groundwater quality field observations unique serve valuable benchmark database relevant numerical studies elsevier ltd rights reserved
respect automotive safety driver plays crucial role stress level tiredness distraction driver therefore high interest paper driver state detection system based cellular neural networks cnns monitor driver stress level presented propose include capacitive based wireless hand detection position touch sensor steering wheel utilizing ink jet printed sensor mats input sensor order improve performance driving simulator platform providing realistic virtual traffic environment utilized conduct study participants evaluation proposed system participant driving two different scenarios representing one two stress stress driver states threefold cross validation applied evaluate concept subject dependence considered carefully separating training testing data furthermore cnn approach benchmarked state art machine learning techniques results show significant improvement combining sensor inputs different driver inherent domains giving total related detection accuracy besides paper shows case including capacitive hand detection sensor accuracy increases findings indicate adding subject independent sensor proposed capacitive hand detection sensor significantly improve detection performance
study uses biogas environmentally friendly renewable energy resource operate prototype micro gas turbine mgt system called proto bioenergy micro gas turbine designed green building application biogas produced anaerobic digester aim research simulate slurry flow anaerobic digester basis developing biogas digester produce biogas meet requirements proto bioenergy micro gas turbine digester rectangular type capacity flow calculations simulations done using computational fluid dynamics cfd methods two dimensional body fitted coordinate mesh simulations conducted various baffle clearances digester cfd simulations showed recirculation phenomena found flows baffle clearance model largest recirculation would lead better mixing slurry
slow wave sleep abnormality reported neuromyelitis optica spectrum disorder nmosd mechanism abnormality unknown determine structural defects brain account decrease slow wave sleep nmosd patients thirty three nmosd patients matched healthy controls enrolled polysomnography used monitor slow wave sleep three dimensional weighted mris obtained assess alterations grey matter volume percentage deep slow wave sleep decreased nmosd patients compared reduction grey matter volume found bilateral thalamus patients lower percentage slow wave sleep fwe corrected cluster level voxels furthermore right thalamic fraction positively correlated decrease percentage slow wave sleep nmosd patients voxels study identified thalamic atrophy associated decrease slow wave sleep nmosd patients studies evaluate whether neurotransmitters hormones stem thalamus involved decrease slow wave sleep
background alteration menstrual cycle individual lifestyles unfavorable habits may cause menstrual irregularity aimed investigate relationship lifestyle factors menstrual irregularity korean women using data fifth korea national health nutrition examination survey knhanes materials methods cross sectional study included nondiabetic korean women aged years take oral contraceptives sex hormonal compounds examined association menstrual irregularity age body mass index bmi drinking experience smoking habits results age asian bmi marriage status age menarche smoking habits significantly associated menstrual cycle irregularity obesity class adjusted presented significantly higher risk menstrual irregularity compared bmi normal weight multivariable analysis revealed high bmi younger women aged years smoking habits middle aged women aged years significantly predicted menstrual irregularity conclusion study substantiated menstrual irregularity closely associated higher bmi smoking habits nondiabetic korean women weight loss smoking cessation recommended promote women reproductive health
goal software testing beyond simply finding defects ultimately testing focused increasing customer satisfaction defects detected areas software customers especially interested cause customer dissatisfaction defects accumulate cause software shunned marketplace therefore important focus reducing defects areas customers consider valuable article proposes value driven model model deals customer values reflects test design increasing customer satisfaction raising test efficiency
paper presents diakoptics methodology diakoptics based actors high performance simulation microgrids microgrids clusters loads microsources operate within single controllable system provides electricity heat local area even get separated distribution system several commercial solutions addressing topic using numerous methods however keep computing time required solve system size system grows represents major challenge paper challenge addressed separating distribution grid independent subnetworks computational implementation subnetwork assigned independent solver using actor model result solution algorithm composed multiple parallel concurrent solvers exchange information using high speed communication interfaces reducing computational burden without losing accuracy diakoptics advanced algorithm combines existing methods simulating large distribution systems methods upgraded make suitable parallel processing cover basic needs simulation smart grid applications
qualitative case study explored one client recovery borderline personality disorder trauma problem gambling client attended months integrative treatment followed years study included data points client therapist data identified three phases treatment first alliance formation normalization appeared mechanisms client experienced dependence second working alliance countertransference appeared mechanisms client experienced reduced gambling suicidal ideation third external controls increased opportunity appeared mechanisms moving world client experience findings give preliminary support phase based constructivist treatment including trauma assessment normalize self feelings countertransference work support motivation restraint case management principles support continuity change efforts
step pool systems occur naturally steep mountain streams man made structures steep channel sections serve energy dissipating structures three different flow regimes may occur dominant flow regime cascading nappe flow regime higher discharges skimming flow regime develops almost plane water surface flow regimes transition flow regime occurs physical model used measure pressure distribution around single step particular step pool geometry different flow regimes nappe transition skimming achieve simultaneously recording piezoresistive pressure transducers distributed around step results showed regime change nappe transition flow associated discontinuity average froude number step pool unit well drops pressures water depth relative instantaneous drag forces reached maximum regime change implies regime change nappe transition flow critical loading case respect stability steps hand mean drag forces showed little systematic variation flow rate changed large spread results measurements repeated flow thus nappe transition flow regimes mean drag force good criterion use predict step stability occurrence different flow regimes could related average froude number step pool unit results practical implications design step pool systems
probe inconsistent link education attitude change toward minority social groups conducted field study focused audience characteristics education lesbian gay transgender lgt targets participants enrolled sexuality course compared neurology course taught professor multiple regression analyses predicted attitude change toward lgt targets social dominance orientation sdo right wing authoritarianism rwa ratings professor characteristics sdo course interaction rwa course interaction sdo course interaction significantly predicted attitude change simple slopes analyses indicated high sdo participants sexuality course showed positive attitude change findings suggest education may reduce prejudice certain audience characteristics
paper addresses makespan minimization problem scheduling flexible job shops whenever exist separable sequence dependent setup times extension neighborhood search functions mastrolilli gambradella developed flexible job shop scheduling problem fjsp provided shown certain conditions extension viable accordingly randomized neighborhood search function introduced best search parameters determined experimentally using modified fjsp benchmark instances tabu search approach utilizing proposed neighborhood search function developed experimentations conducted using modified instances benchmark lower bound experimental results show average tabu search approach capable achieving optimality gaps instances low average setup time processing time ratios elsevier inc rights reserved
backgroundneuregulin nrg novel adipokine expressed adipose tissues enriched brown adipose tissue able improve whole body metabolism rodent thus potential treat obesity associated disorders diabetes however association serum nrg levels diabetes risk human remains unclear study designed examine circulating nrg levels subjects different glucose tolerance status methodsage sex body mass index matched subjects normal glucose tolerance ngt prediabetes diabetes risk evaluation cancers chinese diabetic individuals longitudinal study reaction study included serum nrg measured via enzyme linked immunosorbent assay basic anthropometric parameters fasting plasma glucose hours postload plasma glucose hemoglobin serum lipid profile also measured resultsthe serum nrg levels higher patients diabetes ngt prediabetes diabetes ngt prediabetes median interquartile range nrg concentration correlated fasting plasma glucose top versus bottom quartiles serum nrg concentrations compared adjustment age sex odds ratio observed diabetes prevalence persisted adjusting potential confounding variables nonglucose parameters body mass index waist hip neck circumferences alanine aminotransferase triglyceride high density lipoprotein uric acid estimated glomerular filtration rate also correlated serum nrg conclusionsthe circulating nrg level elevated prediabetic diabetic patients compared control independent risk factor associated diabetes
background infants especially born prematurely increased risk skin breakdown immaturity fragility skin following review existing skin risk assessment tools concluded none provided valid clear concise assessment criteria direction treatment interventions specifically use neonates purpose examine risk factors skin breakdown infants using knowledge interprofessional providers routinely care infants combined scientific knowledge could potentially result valid reliable useable skin risk assessment tool methods using online survey tool rounds delphi technique conducted interprofessional providers routinely care infants round participants asked perceive risk factors skin breakdown neonates responses round categorized themes round respondents asked rank importance themes using point likert scale results data resulted creation seton infant skin risk assessment tool currently validated retrospective chart review responses categorized themes including use medical devices postmenstrual age birth weight activity movement comorbidities skin integrity tolerance moisture chemicals nutrition hydration implications practice infants neonatal intensive care units nicus risk skin breakdown matching risk assessment tool routine skin assessment risk related care plan could result reduction skin breakdown infants implications research retrospective study infants level iii nicus level nicu finalized result infant skin risk assessment tool well tool describing methods minimize risk factor research needed test interrater reliability validity tool increase knowledge skin breakdown prevention practices
extend significantly previous works hilbert space representations generalized uncertainty principle gup dimensions form delta functions however restrict study case commuting focus particular symmetries theory minimal length emerge cases first show algebraic level exists unambiguous mapping gup deformed quantum algebra quadratic hamiltonian standard heisenberg algebra operators aquadratic hamiltonian provided boost sector symmetries modified accordingly theory also mapped completely standard quantum mechanics standard symmetries momentum dependent position operators next investigate hilbert space representations algebraically equivalent models focus specifically whether exhibit minimal length carry functional analysis various operators involved show appearance minimal length critically depends relationship generators translations physical momenta particular relationship preserved algebraicmapping presented paper minimal length present standard gup also present corresponding aquadratic hamiltonian formulation despite perfectly standard algebra model general minimal length requires bounded generators translations specific kind quantization space depends precise shape function defined previously result provides elegant unambiguous classification universal quantum gravity corrections lead emergence minimal length
purpose study compared effects resistance training instability rti neuromuscular total training volume ttv outcomes obtained part instability resistance training trial parkinson disease also used linear multiple regression forward stepwise method identify contribution neuromuscular outcomes previously published improvements timed test unified parkinson disease rating scale motor subscale score methods thirty nine patients moderate severe parkinson disease randomly assigned three groups control rti rti groups performed resistance exercises twice week rti group used unstable devices perform resistance exercises following neuromuscular outcomes assessed quadriceps muscle cross sectional area root mean square mean spike frequency electromyographic signal peak torque rate torque development half relaxation time knee extensors plantarflexors maximum ballistic voluntary isometric contractions ttv calculated lower limb exercises results pre posttraining rti improved neuromuscular outcomes except half relaxation time knee extensors despite lower ttv rti effective increasing root mean square values vastus medialis mean spike frequency gastrocnemius medialis rate torque development plantarflexors stepwise regression identified changes mean spike frequency gastrocnemius medialis best predictor improvements timed test medication unified parkinson disease rating scale motor subscale scores conclusion rti optimizes neuromuscular adaptations partially explains mobility motor sign improvements patients parkinson disease
objective prepulse inhibition ppi blink reflex reduction excitability due conditioning stimulus reflecting sensory gating brainstem structures aimed analyze ppi changes painful episode chronic episodic migraine relation allodynia since abnormal brainstem filtering hypothesized migraine pathophysiology methods included patients migraine headache episode age gender matched healthy subjects recorded unconditioned conditioned supraorbital stimuli conditioned stimuli applied preceding subthreshold stimulus median nerve wrist presence ppi compared two groups well specific parameters latency amplitude area components unconditioned test conditioned ppi paradigms results patient group seven patients ppi whereas healthy subjects ppi healthy subjects displayed significantly increased amplitude reduced amplitude area conditioned stimuli migraine patients observed significant reduction amplitude logistic regression demonstrated allodynia independently related presence ppi beta conclusions study provides evidence sensory gating impairment brainstem level migraine headache related presence allodynia elsevier masson sas rights reserved
background patients chronic granulomatous disease cgd inherit abnormal function nadph oxidase nox suffer hyperinfiammatory responses lung well bacterial fungal infection studies reveal function nox hyperinfiammatory diseases especially asthma exact role nox asthma still unclear controversial therefore attempted clarify exact role nox asthma using various experimental asthma models methods asthma phenotypes analyzed response various allergen induced experimental asthma using nox deficient mice recombinase gene activating deficient mice understand underlying mechanisms exaggerated effector functions investigated degree cell activation levels activation induced cell death aicd regulatory treg cell differentiation nox deficient cells results asthma phenotypes increased enhanced differentiation function nox null mice regardless dose route various allergens nox deficient cells also showed hyperactivation reduced aicd diminished treg cell differentiation increased akt phosphorylation enhanced mitochondrial ros production conclusion findings indicate nox deficiency results exaggerated experimental asthma caused enhanced effector function cell intrinsic manner
triarchic model psychopathy patrick fowles krueger formulated integrative framework reconciling differing conceptions psychopathy model characterizes psychopathy terms distinguishable phenotypic components boldness meanness disinhibition data large mixed gender undergraduate sample used examine relations several best known measures assessing psychopathic traits scores triarchic psychopathy measure tripm inventory developed operationalize triarchic model separate facet scales analyses revealed established inventories psychopathy index components model indexed tripm varying degrees although inventory provided effective coverage meanness disinhibition components instruments differed representation boldness present results demonstrate heuristic value triarchic model delineating commonalities differences among alternative measures psychopathy provide support utility triarchic model framework reconciling alternative conceptions psychopathy
efforts reliable power conversion systems gaining momentum recent years majority studies concerning reliability power switches focus package related failures mainly caused cyclic thermal stress basic failure precursor type stress identified increased state resistance power mosfets recent literature state resistance monitoring converter operation challenging costly task requires current voltage sensing circuits block high voltage across switch state protect measurement control unit paper proposes software frequency response analysis method determine health status high voltage power mosfets high state resistance achieved analyzing evaluating variation plant model double pole frequency using dsp used control purposes proposed concept analyzed boost converter however used detect state resistance variation types converters operating continuous condition mode ccm proposed algorithm embedded low cost dsp experimentally verified boost converter
parametric system identification macroscale resonators operating nonlinear response regime challenging research problem micro nanoscales experimental constraints add additional complexities example due small noisy signals micro nanoresonators produce lock amplifier commonly used characterize amplitude phase responses systems lock enables detection also prohibits use established time domain multi harmonic frequency domain methods rely upon time domain measurements methods used parametric system identification based fitting experimental data approximate solution typically derived via perturbation methods galerkin methods reduced order model thus one could view parametric system identification micro nanosystems operating nonlinear response regime amalgamation four coupled sub problems nonparametric system identification proper experimental design data acquisition generation physically consistent reduced order models calculation accurate approximate responses application nonlinear least squares parameter estimation work focused theoretical foundations underpin sub problems methods used address one sub problem strongly influence results another provide context electromagnetically transduced microresonator used example example provides concrete reference presented findings conclusions elsevier ltd rights reserved
background mucormycosis one rapidly progressing lethal form fungal infection involves nose paranasal sinuses head neck regions mucormycosis also remains threat patients uncontrolled diabetes predisposing systemic conditions manifests rhinocerebral pulmonary gastrointestinal cutaneous disseminated form underlying conditions influence clinical presentation often delay diagnosis resultant poor outcomes case details report case rhinocerebral mucormycosis year old diabetic patient emphasise diagnosis treatment survival options patient potentially fatal fungal infection extra oral examination revealed mild non tender swelling face unable see left eye impaired sense smell difficulty speech nasal stuffiness intra oral examination showed necrosis mucosa underlying bone relation canine tuberosity area left vestibular region maxilla conclusion timely diagnosis critical survival minimization morbidity institution surgical medical therapy critical maximizing likelihood good outcome
development computational thinking skills computer programming major topic education governments around world introducing skills school curriculum consequence educators students facing discipline first time although many technologies assist teachers learners learning competence lack tools support assessment tasks paper compares computational thinking score provided scratch free libre open source software assessment tool scratch mccabe cyclomatic complexity halstead metrics two classic software engineering metrics globally recognized valid measurement complexity software system findings prove positive significant moderate strong correlations could therefore considered validation complexity assessment process scratch
transmissible spongiform encephalopathies tses caused accumulation abnormal prion protein scrapie prpsc prion protein aggregation misfolding cytotoxicity brain major causes neuronal dysfunction ultimate neurodegeneration tses parkin ubiquitin ligase studied extensively major protein misfolding aggregating diseases especially parkinson disease alzheimer disease role parkin tses remains unknown investigated role parkin prion disease cell model neuroblastomaa cells treated prion peptide prp observed gradual decrease soluble parkin level upon treatment prp time dependent manner furthermore endogenous parkin colocalized fitc tagged prion fragment overexpression parkin cells via transfection repressed apoptosis enhancing autophagy parkin overexpressing cells also showed reductions apoptotic bax translocation mitochondria cytochrome release cytosol ultimately inhibited activation proapoptotic caspases taken together findings reveal parkin mediated cytoprotective mechanism prp toxicity novel potential therapeutic target treating prion diseases
accurately scaling sap flux observations tree stand levels requires accounting variation sap flux wood types depth tree however existing models radial variation axial sap flux rarely used difficult implement uncertainty predictive ability calibration measurements often unavailable compare different models diverse sap flux data set test hypotheses radial profiles differ wood type tree size show radial variation sap flux dependent wood type independent tree size range temperate trees best fitting model predicted sample sap flux observations independent estimates sapwood area small errors suggesting robustness new settings develop method predicting whole tree water use model include computer code simple implementation studies
background abnormal responses tactile stimuli common feature autism spectrum disorder asd several lines evidence suggest gabaergic function crucial role tactile processing altered asd study determine whether vivo gaba levels altered children asd whether alterations gaba levels associated abnormal tactile function children methods gaba edited magnetic resonance spectroscopy acquired children autism typically developing children tdc voxels primary sensorimotor occipital cortices children performed tactile tasks previously shown altered asd linked inhibitory mechanisms detection threshold measured without presence slowly increasing sub threshold stimulus amplitude discrimination measured without presence adapting stimulus frequency discrimination measured results sensorimotor gaba levels significantly reduced children autism compared healthy controls occipital gaba levels normal sensorimotor gaba levels correlated dynamic detection threshold well effect sub threshold stimulation sensorimotor gaba levels also correlated amplitude discrimination adaptation effect absent autism frequency discrimination controls children autism conclusions gaba levels correlate behavioral measures inhibition children autism reduced gaba associated abnormalities tactile performance show altered vivo gaba levels might predict abnormal tactile information processing asd gaba system may future target therapies autism res international society autism research wiley periodicals inc
alzheimer disease characterized deposition amyloid beta extracellular plaques hyperphosphorylated tau intracellular neurofibrillary tangles tau pathology characterizes alzheimer disease also many tauopathies presenting tau attractive therapeutic target passive tau immunotherapy previously explored however small fraction peripherally delivered antibodies crosses blood brain barrier enters brain engages tau forms intracellular aggregates efficient ways antibody delivery neuronal uptake warranted brain tau exists multiple isoforms investigated efficacy novel tau isoform specific single chain antibody fragment rnn delivered passive immunization human tau transgenic mouse model demonstrate treated mice rnn reduces anxiety like behaviour phosphorylation tau distinct sites administration rnn combined focused ultrasound scanning mode scanning ultrasound rnn delivery brain uptake neurons markedly increased efficacy significantly enhanced study provides evidence scanning ultrasound viable tool enhance delivery biologics across blood brain barrier improve therapeutic outcomes presents single chain antibodies alternative full length antibodies
accurate prediction software defects crucial importance software engineering software defect prediction comprises two major procedures design appropriate software metrics represent characteristic software system properties development effective regression models count data allowing accurate prediction number software defects although significant research effort devoted software metrics design research count data regression rather limited specifically used methods explicitly designed tackle problem metrics driven software defect counts prediction thus postulating irrelevant assumptions log linearity modeled data addition lack simple efficient algorithms posterior computation made elaborate hierarchical bayesian approaches appear unattractive context software defect prediction address issues paper introduce doubly stochastic poisson process count data regression failure log rate driven novel latent space stochastic feed forward neural network approach yields simple efficient updates complicated conditional distributions means sampling importance resampling error backpropagation exhibit efficacy approach using publicly available benchmark datasets elsevier inc rights reserved
paper compare different technologies support distributed computing means address complex tasks address task gram text extraction big computational given large amount textual data process order deal complexity adopt implement parallelization patterns nowadays several patterns platforms even languages used parallelization task implemented task three platforms mpj express apache hadoop apache spark experiments implemented using two kinds datasets composed large number small files small number large files experiment uses datasets experiment repeats set different file sizes compared performance efficiency among mpj express apache hadoop apache spark final result able provide guidelines choosing platform best suited kind data set regarding overall size granularity input data
usually transport reactions added genome scale metabolic models gsmms based experimental data literature approach allow associating specific genes transport reactions impairs ability model predict effects gene deletions novel methods systematic genome wide transporter functional annotation integration gsmms therefore necessary work automatic system detect classify potential membrane transport proteins given genome integrate related reactions gsmms proposed based identification classification genes encode transmembrane proteins transport reactions annotation generation triage tool identifies metabolites transported transmembrane protein transporter family localization carriers also predicted consequently action confined given membrane integration data provided triage highly curated models allowed identification new transport reactions triage included new release merlin software tool previously developed authors expedites gsmm reconstruction processes
proliferation biological psychiatry greatly increased last two decades possibility carry brain research using modern technical methods seemed social influencing factors would lose importance development mental diseases however actual fact seem justified necessary overcome separation social factors incorporated conceptual framework development mental diseases simultaneously also takes results current neurobiological research consideration aims review article summarize current state sociopsychiatric research emphasize perspectives biological principles validity respect social dimensions psychiatry exemplified schizophrenic disorders article presents options biosocial approach social psychiatry gives overview currently available literature abundance neurobiological research approaches closely associated sociopsychiatric topics social cognition social psychiatry biological psychiatry longer considered diametrically opposed subdisciplines contrary options could emerge synthesis must used research clinical practice
sliding window operations swos widely used image processing applications often performed repeatedly across target image demand significant computing resources processing large images large windows applications real time performance essential running filters cpu often fails deliver results within acceptable timeframe emergence sophisticated graphic processing units gpus presents opportunity address challenge however gpu programming requires steep learning curve error prone novices availability tool produce gpu implementation automatically original cpu source code provide attractive means gpu power harnessed effectively paper presents gpu enabled programming model called gswo assist gpu novices converting swo based image processing applications original source code cuda code highly automated manner model includes new set simple swo pragmas generate gpu kernels support effective gpu memory management implemented programming model based cpu gpu translator cgpu evaluations performed number typical swo image filters applications experimental results show gswo model capable efficiently accelerating applications improved applicability speed performance compared several leading cpu gpu source source translators elsevier rights reserved
conversion mechanical forces vibrations sound energy range milli tens watts also referred small kinetic energies paper electricity received global attention owing potential powering electronic devices however small kinetic energy generators generate electric power result energy storage device required accumulate energy generated reaches sufficient level herein report exceptionally high acoustoelectric conversion ability randomly orientated electrospun poly vinylidenefluoride trifluoroethylene nanofiber nonwoven webs optimized device sound able generate peak voltage current volume power density output based nanofiber web thickness without accumulation energy storage unit electricity generated nanofiber device sufficient light tens commercial leds run electrochemical reactions protect metals corrosion novel acoustoelectric generator may offer effective solution recycling noise pollution usable electricity
lymphedema results impaired lymphatic transport increased limb volume lymphedema divided primary secondary forms upper limb lymphedema secondary breast cancer treatment frequent france primary lymphedema sporadic rarely familial associated complex malformative genetic disorders diagnosis lymphedema mainly clinical lymphoscintigraphy useful primary form assess precisely lymphatic function two limbs erysipelas cellulitis main complication psychological functional discomfort may occur throughout course lymphedema lipedema main differential diagnosis defined abnormal accumulation fat hip ankle lymphedema management based complete decongestive physiotherapy multilayer low stretch bandage manual lymph drainage skin care exercises first phase treatment leads reduction lymphedema volume second phase stabilizes volume multilayer low stretch bandage elastic compression cornerstone complete decongestive physiotherapy patient education programs including self management aim improve patient autonomy societe nationale frangaise medecine interne snfmi published elsevier masson sas rights reserved
paper describes manufacturing engineering technology mnet program south dakota state university sdsu using lean production techniques map educational outcomes across curriculum part accreditation review process mnet program undertaken project determine whether outcomes used program provide value constituents student research team assembled value stream map mnet program educational process needs customer educational outcomes provide value determined surveys interviews constituents program future state map developed compared current state value stream map using information gleaned maps curriculum critically evaluated changed better meet needs constituents
objective icaritin one effective metabolite herba epimedii derived flavonoid icariin strong osteogenic activity however action mechanism remains unclear since primary cilia shown play pivotal role regulating osteogenesis hypothesized primary cilia indispensable mediating icaritin osteogenic effect materials methods primary rat calvarial osteoblasts transfected sirna targeting intraflagellar transport protein ift protein required ciliogenesis prevent formation primary cilium treated icaritin results alkaline phosphatase alp activity significantly increased days cells transfected scrambled sirna control treated icaritin group compared cells transfected scrambled sirna control group alp activity ift sirna transfection icaritin treatment sirna group significantly lower group formation alp positively stained colonies days osteocalcin secretion days formation calcified nodules days displayed similar tendency among three groups mrna expression osteogenesis related genes alp bmp col alpha runx osx significantly increased group different group sirna group protein levels bmp cola runx osx showed similar tendency gene expression conclusion primary cilia important mediating icaritin stimulated osteogenic differentiation may novel target pharmacological therapies bone loss
objective aim study estimate burden direct medical costs unintended pregnancy public payer spain methods economic model evaluating costs outcomes contraceptive use year period constructed women spain aged years risk pregnancy model inputs derived published literature national survey data outcomes evaluated included annual number unintended pregnancy events cost proportion unintended pregnancy events cost due non adherence iii use cost contraceptive methods spain results total number pregnancies estimated unintended associated direct cost burden sic million per year unintended pregnancies occur women aged years whilst total cost burden estimated attributable poor adherence contraceptive methods conclusions cost associated unintended pregnancy high major proportion burden estimated attributable imperfect adherence likely avoidable shifts patterns contraceptive use combined measures improve adherence could substantial positive impact burden
despite several offshore data available general model central part izmit gulf still challenge measurements done hersek peninsula area key point represents onshore segment north anatolian fault naf within central part izmit gulf also new istanbul izmit highway cross gulf zone suspension bridge second longest bridge type world paper integrating different analyses data sets aims verifying present hypotheses particular propose joint interpretation new seismic reflection profiles hersek peninsula well geophysical remote sensing geological data izmit gulf sea marmara turkey close epicenter izmit earthquake identify shallow crustal deformations associated naf seismic reflection profiles first onshore two components records within izmit gulf image compressive features form structural high cut principal deformation zone naf observed transpressive stress pattern appears main factor contributing physiography peninsula together growth northwards yalakdere river deposits demonstrate pattern compatible degrees bending naf strand based new data propose kinematic model evolution structure around hersek peninsula holocene test reconstruction using finite elements numerical simulation model stress strain distribution
dna integrity constantly challenged endogenous exogenous factors alter dna sequence leading mutagenesis aberrant transcriptional activity cytotoxicity left unrepaired damaged dna ultimately lead development cancer overcome threat series complex mechanisms collectively known dna damage response ddr able detect various types dna damage occur stimulate appropriate repair process dna damage repair pathway leads recruitment upregulation activation specific proteins within nucleus cases represent attractive targets molecular imaging given well established involvement ddr tumorigenesis cancer therapy ability monitor repair processes non invasively using nuclear imaging techniques may facilitate earlier detection cancer may also assist monitoring response dna damaging treatment review article aims provide overview recent efforts develop pet spect radiotracers imaging dna damage repair proteins
arteriovenous fistula avf preferred vascular access hemodialysis impact vascular calcification process avf survival remains unclear results several studies issue controversial light new knowledge different susceptibility calcification process different blood vessels aim study analyze whether calcification avf blood vessels may impact avf longevity study included patients males females caucasians mean age years regular hemodialysis year patent primary avfs vascular calcification avf blood vessels anastomotic region detected using ray examination calcification avf blood vessels found patients binary logistic regression analysis demonstrated male gender presence diabetes mellitus longer duration avf calcification determination associated calcification avf blood vessels using cox proportional hazard model adjusted standardized predicted values revealed patients present avf blood vessels calcification increased risk develop avf failure hazard rate confidence interval calcifications avf blood vessels found frequently among dialysis patients may jeopardize survival native avf suggested local ray simple valid method detection patients risk avfs failure monitored closely
purpose review review assess benefit ketamine treatment terminal cancer pain refractory opioid treatment complicated neuropathy recent findings randomized controlled trials consistently show lack clinical efficacy ketamine treating cancer pain large number open label studies case series show benefit summary ketamine methyl aspartate receptor antagonist low dose effective analgesic properties cancer pain ketamine usually prescribed adjuvant opioid therapy pain becomes opioid resistant neuropathic pain symptoms dominate clinical picture literature search revealed four randomized controlled trials examined benefit oral subcutaneous intravenous ketamine opioid refractory cancer pain none showed clinically relevant benefit relieving pain reducing opioid consumption suggests absence evidence benefit ketamine adjuvant analgesic cancer pain findings contrast benefit ketamine observed large number open label studies retrospective case series relate opposite outcomes methodological issues complete picture still insufficient evidence state certainty ketamine effective cancer pain
subclinical hypothyroidism sch common problem pediatric population natural history sch varies depending etiology whether hashimoto thyroiditis negatively affects natural course sch investigated pediatric patients without concomitant diseases predictors levothyroxine medication also evaluated medical records children sch girls years diagnosed retrospectively reviewed patients classified isolated non autoimmune hyperthyrotropinemia iso naht median years follow sch patients eventually initiated levothyroxine patients showed higher probability requiring levothyroxine medication iso naht patients underlying independently predicted deterioration thyroid function leading levothyroxine medication hazard ratios hrs iso naht high titers anti thyroglobulin antibodies tgabs predicted later medication group hrs normal tgabs pediatric sch showed benign self remitting courses underlying significantly increases risk levothyroxine medication especially high titers tgabs
urinary system disorders may prevented achieving good body hydration level bhl paper investigated measurement platform set detecting shade yellow colour urine integration iot principles providing ubiquitous services users citizens propose smart iot based holistic system consists urine colour measurement component fitted urinals based rgb colour theory system implemented using myrio board interacts mobile application bio samples urine gathered volunteers tested using board hand held refractometer results showed possible infer bhl analysing blue values rgb colour comparison recommended urine colour chart believe proposed system promotes sustainable healthy lifestyle ubiquitous self test solution raises bhl awareness greener personal way
monocytes macrophages key mediators inflammation rheumatoid arthritis persistence inflammatory site likely contribute immunopathology sought characterise one mechanism persistence may achieved resistance apoptosis role mir process monocytes peripheral blood pbm synovial fluid sfm patients found resistant spontaneous apoptosis relative pbm healthy control individuals sfm also resistant anti fas mediated apoptosis displayed gene expression profile distinct pbm populations gene expression profiling analysis revealed differentially expressed genes sfm pbm enriched apoptosis related genes showed increased expression mir precursor bic following identification potential mir target transcripts bioinformatic methods show increased levels mature mir expression pbm sfm pbm corresponding decrease sfm two predicted mir target mrnas apoptosis mediators casp apaf using mir mimics demonstrate mir expression healthy cells conferred resistance spontaneous apoptosis fas induced death cells resulted increased production cytokines chemokines collectively data indicate cells patients show enhanced resistance apoptosis suggest increase mir may partially contribute phenotype authors published elsevier ltd
many studies determined traits emotional dysregulation negative affect impulsivity strongest predictors borderline personality disorder bpd although psychodynamic empirically supported bpd treatments transference focused mentalization based focus upon changing internal representations self studies simultaneously evaluated contribution object relations relation traits predicting bpd symptoms study sought determine combined effects emotional dysregulation negative affect impulsivity object relations prediction bpd use mediation modeling priori hypothesized relationships among variables one hundred sixty nine psychiatric outpatients undergraduate students evaluated self reported trait object relations measures administered semistructured diagnostic interviews bpd although trait object relations measures correlated bpd symptoms best fitting model one object relations partially mediated relationship negative affect impulsivity bpd symptoms direct effects traits also observed mediation self reported object relational quality effect prediction bpd previously recognized within trait framework thus supporting model explicated psychodynamic relationally based treatments bpd
investigate sleep disruptions irregular physical activity levels prominent features bipolar disorder relate white matter microstructure patients controls diffusion tension imaging dti day actigraphy recordings obtained patients age gender matched healthy controls tract based spatial statistics tbss used voxelwise analysis association fractional anisotropy sleep activity characteristics overall sample next investigated whether relation sleep activity dti measures differed patients controls physical activity related increased integrity white matter microstructure regardless bipolar diagnosis relationship sleep white matter microstructure equivocal found expected association higher effective sleep controls opposite patterns bipolar patients confounding factors antipsychotic medication use likely explanation contrasting findings highlight need study medication related effects white matter integrity
latterly many problems arising different fields science engineering reduced applying appropriate discretization series time fractional partial differential equations unlike normal case derivative differential order equations fractional order lead new challenges numerical simulation purpose analysis introduce reproducing kernel hilbert space method treating classes time fractional partial differential equations subject neumann boundary conditions parameters derivative arising fluid mechanics chemical reactions elasticity anomalous diffusion population growth models method provides appropriate representation solutions convergent series formula accurately computable components numerical experiments different order derivatives degree performed support theoretical analyses acquired interrupting term exact solutions finally obtained outcomes showed proposed method competitive terms quality solutions found valid solving time fractional neumann problems elsevier ltd rights reserved
background urban settings africa rapidly increasing population traffic related air pollution major contributor outdoor air pollution oap although oap identified leading cause global morbidity mortality however lack simple biomarker assess levels exposure oap resource poor settings study evaluated role exhaled carbon monoxide exhco potential biomarker exposure ambient carbon monoxide ambco oap methods descriptive study conducted among male commercial motorcycle riders cotonou economic capital benin participants ambco measured using portable carbon monoxide data logger period shift exhco measured immediately shift participants asked cook smoke day measurements linear regression analysis used assess association ambco exhco last shift results participants completed study mean age years mean daily income also participants used solid fuels cooking ever smoked average exhco increased ppm end shift post shift exhco significantly associated ambco association strongest last oap exposure exhco measurement beta conclusion exhco level associated recent exposure ambco oap measurable increase exposure findings suggest exhco may potential biomarker short term exposure oap
materials genome given rather vague definition president obama announcement argue materials genome analogously biological genomes defined set information databases allowing prediction material structure well response processing usage conditions materials genome thus encoded language calphad thermodynamics kinetics databases major parts integrated computational materials engineering acta materialia inc published elsevier ltd rights reserved
cocaine dependence often occurs cluster personality disorders since disorders characterized emotion regulation deficits predicted cocaine comorbid patients would exhibit dysfunctional patterns brain activation connectivity reappraisal negative emotions recruited cocaine users comorbid cluster personality disorders cocaine users without comorbidities controls scanned using functional magnetic resonance imaging fmri performance reappraisal task maintain suppress emotions induced negative affective stimuli followed region interest roi whole brain approaches investigate brain activations connectivity associated negative emotion experience reappraisal results showed cocaine users comorbid personality disorders reduced activation subgenual anterior cingulate cortex negative emotion maintenance increased activation lateral orbitofrontal cortex amygdala reappraisal amygdala activation correlated impulsivity antisocial beliefs comorbid group connectivity analyses showed cocaine comorbid group subgenual cingulate less efficiently connected amygdala fusiform gyri efficiently connected anterior insula maintenance whereas reappraisal left orbitofrontal cortex efficiently connected amygdala right orbitofrontal cortex less efficiently connected dorsal striatum conclude cocaine users comorbid cluster personality disorders distinctive patterns brain activation connectivity maintenance reappraisal negative emotions correlate impulsivity dysfunctional beliefs elsevier ecnp rights reserved
introduction growing evidence mailed distribution free nicotine replacement therapy nrt usually part smokers helplines effective increasing odds cessation population level however limited information available utilization nrt provided free factors associated regimen adherence remained largely unexplored methods context randomized controlled trial adult smokers across canada hypothetically interested free nrt mailed week supply nicotine patches tither support offered analyses evaluated priori defined demographic smoking characteristics predicted nicotine patch use week follow patch recipients well examined association patch use smoking cessation months results weeks used used used provided nicotine patches lower age unemployment past nrt use intent quit next days baseline preparation stage change identified independent predictors nicotine patch use use patches associated greater odds smoking cessation compared non users adj conclusions mailed distribution free nicotine patches smokers large effective promoting cessation particularly among financially disadvantaged groups previous nrt experience among individuals already advanced intent quit elsevier ltd rights reserved
coccidioidal meningitis devastating complication coccidioidomycosis since late intrathecal amphotericin deoxycholate ambd successfully used treat often cure disease reducing mortality rates approximately introduction azoles revolutionized treatment coccidioidal infections however ambd remains known curative option management use ambd well described many articles discuss actual methods behind preparation titration dosing strategies utilized practitioners kern medical bakersfield california years experience utilization ambd treatment article describes practice experience treatment preparation ambd different dosing strategies used regard route administration cisternal lumbar ventricular
field manufacturing engineering process designers conduct numerical simulation experiments observe impact varying input parameters certain outputs production process disadvantage simulations time consuming results help fully understand underlying process instance common problem planning processes choice appropriate machine parameter set results desirable process outputs one way overcome problem use data mining techniques extract previously unknown valuable knowledge simulation results paper presents hybrid machine learning approach applying clustering classification techniques laser cutting planning process first step clustering algorithm used divide large parts simulation data groups similar performance values select groups major interest high cut quality results next classification trees used identify regions multidimensional parameter space related found groups evaluation shows models accurately identify multidimensional relationships input parameters output values process addition combination appropriate visualization techniques clustering interpretable classification trees allows designers gain valuable insights laser cutting process aim optimizing visual exploration
serum concentrations neuroactive androgens decline older men studies low testosterone associated decreased cognitive function incidence depression existing studies evaluating effect testosterone administration cognition older men largely inconclusive studies reporting minor moderate cognitive benefit others indicate cognitive effect objective assess cognitive effects treating older hypogonadal men year supraphysiological dose testosterone either alone combination finasteride type alpha reductase inhibitor order determine whether testosterone produces cognitive benefit whether suppressed dihydrotestosterone influences cognition sixty men aged years serum testosterone concentration bioavailable testosterone evidence cognitive impairment received testosterone enanthate week versus vehicle paired finasteride day versus placebo using factorial design testosterone caused small decrease depressive symptoms assessed geriatric depression scale moderate increase visuospatial memory assessed performance recall trial rey osterrieth complex figure test finasteride caused small increase performance benton judgment line orientation test total major improvements cognition observed either testosterone finasteride studies warranted determine testosterone replacement may improve cognition domains
permanent magnet synchronous machines performance highly dependent permanent magnets pms temperature however temperature measurement easy normally implemented standard machines alternatively temperature estimated temperature estimation methods divided three major groups thermal modelbased methods bemf based methods methods based injection form high frequency signal stator terminals machine one concern thermal model based methods model often needs adjusted machine design application knowledge machine geometry materials cooling system therefore required contrary bemf methods methods based high frequency signal injection estimate magnet temperature measurable electrical variables knowledge geometry cooling system required though use type signals bemf high frequency signal injection methods present relevant differences paper realizes comparative analysis methods physical principles performance implementation addressed
visualization applications performed distinct platforms mobile devices multi projection systems platform offers specific features provide data understanding system integrates platforms complementary manner real challenge paper present immersive interactive visualization system aims explore data relational databases using graphs representations multiple simultaneous users visualize interact data multi projection system mobile devices single visualization application created platforms using unity game engine unity external package virtual reality applications development supports multi projection system cluster passive stereoscopy visualization system aims provide users better data understanding using screens multi projection system data overview mobile devices display interaction device navigation additional information visualization also introduce user case visualization system used order support developers regarding structural problems large relational database
aimthe objective review assess chronic kidney disease related frailty cognitive impairment well probable causes mechanisms interventions methodsstudies reviewed evaluate relationship chronic kidney disease physical frailty cognitive impairment studies initial search longitudinal studies keywords cognitive ckd longitudinal cross sectional studies keywords frailty ckd included final analysis resultsby pooling current research show clear evidence relationship chronic kidney disease frailty cognitive impairment major studies vascular disease likely important mediator particularly cognitive impairment however non vascular factors also play important role many mechanisms contribute impaired cognitive function increased frailty ckd remain elucidated limited studies medication therapy obtain ideal effect limited data treatment strategies addressing vascular disease risk factors earlier life might decrease subsequent burden frailty cognitive impairment population multidimensional interventions address microvascular health factors may substantial benefits cognitive impairments physical frailty vulnerable population conclusionschronic kidney disease potential cause frailty cognitive impairment vascular non vascular factors possible causes mechanism chronic kidney disease induced physical frailty cognitive impairment suggests multidimensional interventions may effective therapeutic strategies early stage chronic kidney disease geriatr gerontol int
although number studies observed females respond better serotonergic antidepressants males postmenopausal females diminished response antidepressants compared younger females also studies conflict findings making generalizations regarding sex differences difficult make sex variance antidepressant efficacy pharmacokinetics profiles attributed sex based physiological differences behavioral differences related disorders sex specific conditions including pregnancy menopause paper review history current research sex effects antidepressant treatment aich servier research group
background visual evoked potential may useful method understanding pathophysiologic mechanisms involved genesis migraine study vep evaluated tool assess visual function migraine aura without aura materials methods migraine patients without aura aura equal number healthy controls enrolled study pattern reversal vep using checker board performed compared three groups latency amplitude consistent prominent wave vep analysed vep parameters migraine patients correlated frequency attacks disease duration design descriptive study results migraine patients aura showed significantly prolonged vep latency compared migraine without aura control groups vep latency showed significant positive correlation duration frequency migraine attacks latency increasing increased duration migraine frequent attacks conclusion involvement visual system migraine aura rather migraine without aura vep could regarded useful reliable technique assessment visual dysfunction migraine manifesting predominantly prolongation latency
cleaning horizontal water jet impinging onto soiled perspex vertical plate described plate substrate coated pva petroleum jelly soil substrate either fixed batch tests cleaned area roughly circular grew time substrate moved vertically plane water jet remaining fixed reproduced effect jet moving across surface cleaning found real tank cleaning operations batch experiments growth radius cleaning area well described early times initial radius cleaned area time constant later times petroleum jelly cleaning front reached maximum value outward momentum radially flowing water film balanced strength soil maximum value modelled ramp viscoplastic soil inclined angle chi substrate surface chi found vary degrees degrees tests continuous cleaning petroleum jelly lengthening cleaned area width observed moving substrate near jet stationary clean front whose shape looked like half ellipse shape width well described theory wilson using parameters mentioned batch experiments establishes good link batch continuous cleaning experiments elsevier ltd rights reserved
antibiotic water pollution caused discharge untreated antibiotic waste water sewage animal husbandry increasingly severe especially developing countries however current water treatment methods antibiotic polluted water complicated expensive time consuming developed highly effective enzymatic ultrafiltration membrane extremely simple degrade antibiotic fast manner low cost penicillinase representative enzyme antibiotic degradation covalently immobilized bromomethylated poly dimethyl phenylene oxide bppo ultrafiltration membrane simple self assembling process membrane immobilized penicillinase thoroughly degrade antibiotic single passing polluted water treatment capacity small piece membrane provide sufficient clean drinking water family people per day overnight furthermore engineered enzymatic membrane attractive stability reusability long term application anticipate enzymatic membrane serve practical low cost solution antibiotic pollution particular providing antibiotic free drinking water developing countries elsevier rights reserved
paper responds increasing need earth observation missions deals design repeating sun synchronous constellations rsscs takes consideration constellations composed one orbital planes based mature design approach repeating sun synchronous orbits novel technique design rsscs presented takes second gravitational zonal harmonic consideration order obtain regular cycles observation earth single satellite orbital relationships satisfied firstly illustrated making full analyses characteristics satellite ground track orbital parameters properly calculated make satellites pass different ground track single satellite last single plane multi plane constellations used improve repetitions observation ground resolution rsscs allow observing region local time solar day several times different local time solar day therefore kind constellations meets requirements remote sensing applications need observe region different visible conditions various case studies calculation technique successfully demonstrated cospar published elsevier ltd rights reserved
interleukin pleiotropic cytokine important role immune regulation exercise metabolism exercise predominantly produced within released working skeletal muscle magnitude release related duration intensity exercise bout first cytokine appear circulation following initiation exercise undergoes pronounced increase compared cytokine response exercise last decade studies suggested role muscle energy sensor pointing potential role biomarker overtraining currently elisa western blot staple detection technique however require substantial time cost machinery specialist training hand graphene oxide based amperometric sensor provide real time low cost yet sensitive protein detection coverage mono layered graphene oxide flake sio substrate limited due rinsing unwanted crosslinking aminopropyltriethoxy silane aptes adhesion layer thus leading low available surface area high variability electrical conductivity chips low sheet transconductance limits sensitivity sensor work overcome limitation depositing carbon edges flakes using ethanol chemical vapor deposition cvd post treated fabricated liquid gated biosensor detection window presented work yielded highly conductive electrically homogeneous carbon based transducer enable low cost facile real time yet sensitive amperometric sensors authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
objectiveto provide clinically relevant insights identification muscles techniques involved safe effective use onabotulinumtoxina chronic migraine prophylaxis backgroundalthough guidance use onabotulinumtoxina chronic migraine available based phase iii research evaluating migraine prophylaxis therapy preempt clinical program clinical experience shown insufficient understanding anatomy function head neck muscles may lead undesirable outcomes suboptimal efficacy design methodseach muscle involved standardized preempt injection paradigm reviewed thorough description muscle anatomy muscle description location innervation vascular supply function key insights based clinical experience also provided help improve outcomes resultsthe identification muscles preempt injection paradigm based patient unique anatomy injections administered using advised techniques thorough examination patient prior treatment also critical determine preexisting conditions may increase risk unwanted outcomes appropriate expectations communicated conclusionsthorough knowledge functional anatomy muscles involved standardized preempt injection paradigm critical achieve efficacy safety observed clinical trials addition important assess patient baseline condition anticipate risk unwanted outcomes may result treatment
critically reviewing divisions imitation proposed dryden genette among others author discusses evolution concept origins latest development modern england aim build objective model analyzing imitation form translation analyzes case study east asia japanese manga imitations chinese novel journey west particular minekura kazuya journey extreme gens bar maden saiy bar author seeks show changes made manga artists plot characters exemplify ways imitations function new context article ends historical reflections position imitation translation theory practice relating contemporary context hoped discussion contribute dispelling misunderstandings prejudice towards imitation time encouraging renewed attention old concept
regenesees new software system design based model assisted analysis complex sample surveys based compared traditional estimation platforms ensures easier safer usage achieves dramatic reduction user workload calibration variance estimation tasks indeed regenesees allows specification calibration models symbolic way using model formulae driven symbolic metadata system automatically transparently generates right values formats auxiliary variables sample level assists user defining calculating corresponding population totals moreover regenesees handle arbitrary complex estimators provided expressed differentiable functions horvitz thompson calibration estimators totals complex estimators defined completely free fashion user needs provide system symbolic expression estimator mathematical function regenesees fact able automatically linearize complex estimators estimation variance comes cost user remarkably innovative features sketched leverage particular strong point programming language namely ability process symbolic information
objective getting good night sleep important ensure function effectively waking lives one area particularly compromised adequate sleep achieved affect regulation implications subjective well swb lens homeostasis theory investigation relationship self reported sleep quality stress swb undertaken australian sample primary aim understanding importance sleep role regard affect regulation method study included australian participants female mean age standard deviation recruited via advertisements social media websites participants completed measures swb sleep quality dreaming stress results using bootstrapped mediation analysis sleep quality found partially mediate relationship stress swb results explored using two way analysis variance revealed significant main effects sleep stress swb significant interaction effect finally nightmares bad dreams reported higher stress bad dreams nightmares conclusion findings provide preliminary evidence suggest impact stress swb may reduced adequate sleep quality achieved contribute growing field literature exploring function dreams findings provide new insight inform therapeutic approaches sleep disorders stress management guide clinical interventions
limited research predictors readmission bipolar disorder carried year follow patients discharged single mental health unit following admission treatment acute bipolar episode patients followed year readmitted association readmission drug regimen prescription antidepressants discharge associated increased risk readmission odds ratio confidence interval among demographic factors smoking age range years conferred increased risk readmission individually optimized drug treatment regimens equally effective practice clear smoking associated readmission
study aimed investigate effects social versus non social stimuli postural responses boys autism spectrum disorder asd mean age compared typically developing boys mean age postural control children examined standing force plate viewing images object male face female face sequence image shown two trials trial lasted results indicated significant interaction group task meaning children asd children showed increased postural sway face tasks object task furthermore children higher autism severity compared lower severity showed increased change response social stimuli seems postural control children asd affected social stimuli children
validity proposed sfg model verified comparing theoretical results originally obtained values also introduced weighted averaging method improve parameters estimation accuracy
non verbal communication incorporating visual audio contextual information important make sense navigate social world individuals trouble social situations often difficulty recognizing sorts non verbal social signals article propose training tool nocoa non verbal communiation autism plus uses utterances visual audio modalities nonverbal communication training describe design nocoa perform experimental evaluation examine potential tool computer based training non verbal communication skills people social communication difficulties series four experiments investigated effect temporal context ability recognize social signals testing context effect modality presentation social stimulus ability recognize non verbal information correlation autistic traits measured autism spectrum quotient non verbal behavior recognition skills measured nocoa effectiveness computer based training improving social skills found context information helpful recognizing non verbal behaviors effect modality different results also showed significant relationship communication socialization scores non verbal communication skills social skills significantly improved computer based training
paper proposed ambient light ambilight new type signal sources positioning possibility methods ambilight positioning presented paper shown two kinds observables ambient light used positioning different principles ambilight intensity spectrum measurements highly location dependency used positioning traditional fingerprinting approach total ambilight irradiance intensity used detect proximity lighting source location solution resolved support knowledge lighting infrastructure ambilight positioning work areas traditional techniques able function ambilight sensor cost efficient miniature size easily integrated sensors form hybrid positioning system paper concluded discussions possibility applicability challenges outlook new ambient light positioning techniques
study aimed examine discrete impacts peak oxygen consumption brain natriuretic peptide bnp levels future heart failure events sinus rhythm atrial fibrillation total patients underwent symptom limited cardiopulmonary exercise testing whose bnp values determined simultaneously analysed events defined hospitalization death mean follow period days events observed high bnp value dichotomized median value independently associated events patients significant interaction rhythms contrast low peak independently associated events rhythms marginal interaction bivariate cox models low peak much stronger predictive power events high bnp whereas high bnp powerful low peak prognostic value bnp peak future events seemed different
object study develop self tuning fractional order proportional integral derivative sfopid controller controlling mover position direct drive linear voice coil motor vcm accurately different operational conditions fractional order proportional integral derivative fopid controller improve control performances conventional integer order pid controller respect additional fractional differential integral orders however choosing five interdependent control parameters including proportional integral derivative gains well fractional differential integral orders appropriately arduous practical applications regard sfopid controller proposed five control parameters optimized dynamically concurrently according adaptive differential evolution algorithm high efficiency adaptive selection mechanism experimental results reveal sfopid controller outperforms pid fopid controllers regard nonlinear vcm control system nominal payload conditions
reduced habituation aversive stimuli observed adolescence may reflect underlying mechanism vulnerability anxiety disorders study examined startle reflex fear learning task year old girls examined relationship mean startle startle habituation pubertal development two measures linked risk anxiety behavioral inhibition system bis error related negativity ern puberty bis ern unrelated mean startle however measure modulated startle habituation greater pubertal development associated reduced startle habituation across higher bis related larger ern associated reduced startle habituation specifically effects independent findings suggest puberty alters habituation defense system activation threat safety cues independent risk anxiety uniquely impacts habituation threat cues
background anorexia nervosa characterised severe malnutrition well intense fear anxiety around food eating associated anomalies information processing previous studies found neuropeptide oxytocin influence eating behaviour lower neurobiological stress response anxiety among clinical populations alter attentional processing food eating related images methodology thirty adult women twenty nine healthy comparison women took part current study study used double blind placebo controlled crossover design investigate effects single dose intranasal oxytocin standard laboratory smoothie challenge salivary cortisol anxiety attentional bias towards food images smoothie challenge participants attentional bias assessed using visual probe task results relative placebo intranasal oxytocin reduced salivary cortisol altered anomalies attentional bias towards food images group oxytocin induced reduction attentional avoidance food images correlated oxytocin induced reduction salivary cortisol group smoothie challenge intranasal oxytocin significantly alter subjective feelings anxiety intake smoothie challenge groups conclusions intranasal oxytocin may moderate automated information processing biases reduce neurobiological stress investigation effects repeated administration oxytocin processes well eating behaviour subjective anxiety would interest authors published elsevier ltd
type diabetes mellitus tdm genetic testing undergoing clinical trials measure efficacy genetic counseling behavior based risk reduction expectations patients bring testing process may play important role individual outcomes conducted qualitative exploration anticipated decision making expectations around tdm genetic testing semi structured interviews completed mexican americans non hispanic black americans non hispanic white americans risk tdm transcripts analyzed themes participants would accept tdm genetic testing order motivate risk reducing behaviors apprise family members risk participants would decline testing wished avoid emotional distress believed test would reveal new risk information non hispanic whites college education declined genetic testing often groups without college education likely testing expectations discordant current science conflating genetic testing common blood tests understanding expectations decision making factors around tdm genetic testing better prepare healthcare professionals counsel patients may lead higher efficacy tdm genetic testing counseling
paper show construct data structure string size compressed context free grammar size supports efficient karp rabin fingerprint queries substring given indices answer query fingerprint substring present first space data structures answer fingerprint queries without decompressing characters straight line programs slp get log query time linear slps slp derivative captures compression variations get log log query time extend result solve longest common extension problem query time log log log log log log log slps linear slps respectively denotes length lce elsevier inc rights reserved
alzheimer disease major cause dementia worldwide edaravone potent free radical scavenger reported neuroprotective present study designed investigate effect chronic edaravone administration intracerebroventricular streptozotocin icv stz induced cognitive impairment male wistar rats cognitive impairment developed single icv stz injection bilaterally day edaravone orally daily administered days morris water maze passive avoidance tests used assess cognitive functions baseline days icv stz caused cognitive impairment evidenced increased escape latency decreased time spent target quadrant morris water maze test reduced retention latency passive avoidance test stz caused increase oxidative stress cholinesterases inflammatory cytokines protein expression rock decrease protein expression chat edaravone ameliorated stz induced cognitive impairment stz induced increase oxidative stress increased levels pro inflammatory cytokines tnf alpha beta mitigated edaravone edaravone also prevented stz induced increased protein expression rock moreover edaravone significantly prevented stz induced increased activity cholinesterases cortex hippocampus decreased expression chat caused stz brought towards normal edaravone hippocampus results thus show edaravone protective stz induced cognitive impairment oxidative stress cholinergic dysfunction altered protein expressions study thus suggests potential edaravone adjuvant treatment alzheimer disease
whereas primary prevention seeks forestall development disease individuals elevated risk primordial prevention seeks preempt development risk factors health behaviors characterized lifestyle factors key interventional targets primordial prevention cardiovascular disease appropriate dietary intake including limiting salt saturated fat consumption reduce risk developing hypertension dyslipidemias regular physical activity associated lower blood pressure healthier lipid profiles diet exercise critical maintaining weight conducive cardiovascular health behavioral factors stress management sleep duration portion control meal timing may play role weight management offer additional routes intervention smoking elevates cardiovascular risk although lifestyle modification programs instrumental reaching public health goals maintaining cardiovascular health matter solely willpower ideally structural social forces make healthy lifestyles default option
objective study evaluates potential gingival crevicular fluid serum cytokines hiv stage biomarkers methods gingival crevicular fluid gcf serum samples hiv positive adult male subjects cases hiv negative male subjects controls mexico examined cytokines using multiplex elisa participants divided five subgroups hiv stage infection age specific lymphocyte count antiretroviral therapy art correlated cytokine levels results gcf concentrations csf mcp well serum concentrations beta showed statistically significant difference among subgroups found significant effect size correlation cytokines expression levels subjects art showed significantly higher levels analyzed cytokines compared rest found gcf significant predictor non art hiv status observed result gcf csf art short term group serum csf art long term subgroup conclusion results indicate high variability gcf serum cytokines concentrations low frequency detection different hiv art stages however within limits present study gcf serum cytokine concentrations correlate positively oral periodontal innate immunity affected hiv viremia art gcf csf well serum mcp csf may useful biomarkers detection disease presence severity due hiv infection art use elsevier ltd rights reserved
emerging field precision medicine emphasizes individualized approach prevention diagnosis treatment disease using information individual genetics environment lifestyle epigenetics fields precision medicine practitioners maximize resources targeting pathology human performance molecular level however practitioners may aware topics within field therefore purpose review introduce basic concepts precision medicine highlight potential application sports medicine performance enhancement review provides practical suggestions implementation currently available precision medicine concepts sport
neutrophils essential healthy life yet pose threat improperly controlled neutrophil perversion well documented variety inflammatory disorders arthritis lupus psoriasis beginning demystified autoimmune demyelination common cause neurological disability young adults using animal model experimental autoimmune encephalomyelitis eae several molecules help neutrophils invade central nervous system cns identified mechanisms neutrophils may contribute demyelination also proposed secretion endothelial leukocytic modulators antigen presentation cells myelin degradation phagocytosis human neutrophils seen cns people neuromyelitis optica spectrum disorder severe variants autoimmune demyelinating diseases time autopsy multiple sclerosis often many years onset neutrophils appear escaped scene crime however new clues implicate neutrophils relapses progression warrants investigating differential importance neutrophils among demyelinating diseases largely unknown effects current therapies neutrophils potential neutrophil proteins clinical biomarkers therapeutic targets elsevier rights reserved
increasing evidence suggests pain related fear key transition acute chronic pain previous research shown perceptual similarity pain associated movement fosters generalization fear novel movements perceptual generalization pain related fear adaptive enables individuals extrapolate threat value one movement another without necessity learn anew however excessive spreading fear safe movements may become maladaptive may lead sustained anxiety dysfunctional avoidance behaviors severe disability hallmark human cognition ability extract conceptual knowledge learning episode well although conceptual pathway may important understand fear generalization chronic pain research topic lacking investigated acquisition generalization concept based pain related fear acquisition unique exemplars one action category opening boxes followed pain whereas exemplars another action category closing boxes subsequently spreading pain related fear novel exemplars action categories tested participants learned expect pain occur reported pain related fear exemplars category compared category generalization fear expectancy generalized novel exemplars category category pattern corroborated eyeblink startle measures first study demonstrates pain related fear acquired generalized based conceptual knowledge
modern raid structured storage systems reliability guaranteed use parity blocks parity update overheads upon write request become performance bottleneck raid systems ways attached log disk used improve write performance delaying parity blocks update however methods data block oriented need time rebuild synchronize raid system data disk log disk fails paper propose novel optimization method called swo improve raid write performance reconstruction performance moreover handling write request swo chooses reconstruction write read modify write combining log information minimize number pre read data blocks implemented proposed swo prototype carried performance measurements using iometer raidmeter implemented main idea raidl raid call raidl time evaluated reconstruction time synchronization time swo experiments demonstrate swo significantly improves write performance saves time data logging raidl rebuilding synchronizing
extract corchorus olitorius stems ecs used green inhibitor inhibition mild steel corrosion hso solution used qualitative quantitative analysis extract corrosion performance extract evaluated using electrochemical impedance spectroscopy potentiodynamic polarization weight loss results showed ecs mixed type inhibitor reduces anodic cathodic reactions inhibition efficiency reached adsorption isotherm data recorded different temperatures analyzed selected adsorption isotherm models reveal characteristics inhibition thermodynamic calculations showed inhibition efficiency increases increasing inhibitor concentration decreases increasing temperature adsorption ecs mild steel surface found spontaneous exothermic adsorption suggested physisorption according awady isotherm model also scanning electron microscopy sem used investigate surface morphology confirm corrosion results
computational demand exact search procedures pressed exploitation parallel processing accelerators reduce execution time many applications however often imposes strict restrictions terms problem size implementation efforts mainly due possibly distinct architectures circumvent limitation new exact search alignment tool bowmapcl based burrows wheeler transform index presented contrasting alternatives bowmapcl based unified implementation using opencl allowing exploitation multiple possibly different devices nvidia amd ati intel gpus apus furthermore efficiently exploit heterogeneous architectures bowmapcl incorporates several techniques promote performance scalability including multiple buffering work queue task distribution dynamic load balancing together index partitioning bit encoding sampling compared state art tools attained results showed bowmapcl using single gpu faster mainstream multi threaded cpu bwt based aligners like bowtie bwa soap faster best performing state art gpu implementations namely soap hpg bwt multiple completely distinct devices considered bowmapcl efficiently scales offered throughput ensuring convenient load balance involved processing several distinct devices
optically transparent doped borate glasses chemical composition zno lio nao dyo mol synthesized melt quenching technique characterized ray diffraction xrd scanning electron microscopy energy dispersive ray analysis sem edx attenuated total reflectance fourier transform infrared atr ftir spectroscopy raman spectroscopy thermo gravimetric analysis tga differential scanning calorimetry dsc optical absorption luminescence techniques amorphous nature prepared glasses confirmed xrd sem measurements edx spectra show elements present respective glasses vibrational features various functional groups like stretching vibrations linkages tetrahedra asymmetric stretching vibrations bond trigonal units stretching vibrations units vibrations bonds zno groups bending modes zno units vibrational modes due alkali borates identified atr ftir raman spectroscopy prepared glasses weight loss glass transition onset crystallization crystallization melting temperatures determined tga dsc measurements respectively following obtained values thermal stability delta hruby values determined calculated delta values increased temperature range degrees values varied range concentration increment mol increasing stability glasses shows thermally resistant optical properties titled glasses explored absorption photoluminescence excitation ple photoluminescence spectra mol doped glass obtain information concerning nature ligand field environment around ions judd ofelt intensity parameters ohm lambda lambda evaluated measured oscillator strengths various absorption bands radiative parameters radiative transition probabilities branching ratios beta radiative lifetimes tau main emission transitions calculated using parameters photoluminescence properties examined ultraviolet near nuv blue excitations luminescence spectra measured different concentrations doped glasses exciting glasses wavelengths show concentration quenching beyond mol luminescence quenching explained using cross relaxation channels resonant energy transfer ret mol doped glass measured decay lifetime evaluated quantum efficiency values similar respectively following luminescence spectra yellow blue luminescence intensity ratios color chromaticity coordinates correlated color temperatures cct glasses also estimated evaluate white light generation respect ion concentration color coordinates cct values mol doped glass optimum concentration represent warm white light region selected blue excitation wavelengths obtained results indicate optimized mol doped glass may useful warm white light emitting applications well solid state yellow laser emission luminescent display devices elsevier rights reserved
signal flow graph expressed matrix form mason formula expressed analytical way instead topology form result used control system cad software get system models symbolically numerically approach flexible efficient methods available
recent research interactive electronic systems like computers improve quality life many researchers students professors etc case disabled people technology helps engage fully world study aims evaluate interfaces curves drawing movements face article discusses motivations build software software works iterative development software user testing people without disabilities
leao spreading depression cortical activity propagating silencing neuronal activity resulting spreading depolarization evaluated contributions action potential failure adenosine receptor activation depression evoked spontaneous electrocorticographic ecog activity vivo anesthetized mice compared depression induced effects dependent transmission synaptic potentials transcallosal thalamocortical pathways aps recovered rapidly within min demonstrated evoked activity distant projection targets evoked corticocortical postsynaptic potentials recovered next within similar min spontaneous ecog evoked thalamocortical postsynaptic potentials recovered together similar min duration ecog depression shortened systemic focal administration competitive antagonist cyclopentyl dipropylxanthine dpcpx ecog depression also shortened focal application exogenous adenosine deaminase ada conversely prolonged non competitive ada inhibitor deoxycoformycin dcf concluded initial depolarization block brief adenosine activation part contributes persistent secondary phase leao cortical spreading depression
paper optimal design electric vehicle charging station evcs goal minimizing lifecycle cost taking account environmental emissions presented different energy sources renewable energy technology based diesel generation considered realistic inputs physical operating economic characteristics order address range anxiety concern owners regarding distance vehicle travel design evcs along highways isolated microgrid studied another study evcs assumed connected grid smart energy hub charging demand evcs estimated considering real drive data analysis also carried compare economics grid connected evcs isolated evcs optimal break even distance grid connected evcs viable option determined elsevier ltd rights reserved
assess role single photon emission computed tomography computed tomography spect identification sentinel lymph nodes slns patients early stage oral cancer clinically negative neck addition planar lymphoscintigraphy spect performed consecutive patients early stage oral cancer clinically negative neck addition spect planar images retrospectively analyzed number additional slns precise localization slns importance anatomical information team consisting nuclear physician surgeon investigator identification rate imaging modalities combined spect identified additional slns patients additional slns metastasis found resulting upstaging rate patients least one positive sln positive sln detected due addition spect spect considered add important anatomical information two patients patients initially scored slns planar lymphoscintigrams scored non slns spect added four false negative sln biopsy procedures cohort addition spect planar lymphoscintigraphy recommended identification positive slns better topographical orientation surgery sentinel lymph node biopsy early stage oral cancer
korteweg vries equation kdv dimensional nizhnik novikov veselov system nnv presented multi soliton rational solutions equations obtained via generalized unified method analysis emphasizes power method capability handling completely partially integrable equations compared hirota method inverse scattering method proposed method gives general exact multi wave solutions without much additional effort results show virtue symbolic computation generalized unified method may provide straightforward effective mathematical tool seeking multi soliton rational solutions solving many nonlinear evolution equations arising different branches sciences
self injurious behaviors sibs leading causes death injury unfortunately disagreement regarding whether classify suicidal nonsuicidal sibs contributed mis classification likely hindering clinical care impeding scientific progress present study utilized data driven approach facilitate classification measurement three forms sibs particular focus one scant clinical scientific attention nonsuicidal overdoses intentional overdoses person states intention dying overdose results study demonstrated nonsuicidal overdoses similar suicide attempts terms age onset similar nonsuicidal self injury nssi terms suicidal thoughts desire die engaging behaviors nonsuicidal overdoses unique nssi suicide attempts terms reported likelihood dying behavior present study highlighted current definitions nonsuicidal behaviors including requirements person zero intent die may accurately represent people intent engaging behaviors additionally present study highlighted empirical analysis sibs provide important insights classification sibs elsevier ireland ltd rights reserved
strengths difficulties questionnaire sdq designed screen behavioral problems youths based cutoff points favor instrument diagnostic sensitivity present study aimed analyze discriminative validity sdq identify behavioral difficulties prosocial resources school age children compared diagnostic data collected corresponding sections development well assessment dawba addition new cutoff points value specificity defined sdq scales exploring diagnostic potential study conducted brazil assessed community convenience sample consisted children aged years psychological psychiatric treatment mothers participants also completed sociodemographic questionnaire descriptive statistics used clinically characterize sample roc curve used assess discriminant validity sdq new cutoff points established maximize instrument specificity new cutoff points enabled significant increase specificity without significant loss sensitivity favors approaches based measures screening diagnosis yet damage instrument screening capacity following increases observed depressive disorder scale cutoff point generalized anxiety disorder scale cutoff point conduct disorder scale cutoff point hyperactive disorder scale cutoff point antisocial personality disorder scale cutoff point cutoff point applied prosocial behavior scale exhibited increase specificity use specific cutoff points generated accurate results favored sdq use particularly contexts care require precise faster procedures identification problems
paper new approach optimization multi objective injection molding process based taguchi robust design combined grey relational analysis studied grey relational grade obtained multi objective grey relational analysis used solve injection molding process multiple performance characteristics including volume shrinkage axial deformation injecting parameters namely mold temperature melt temperature holding pressure holding time optimized orthogonal polar difference analysis statistical analysis variance anova grey relational grade main factors influencing best process parameters determined degrees degrees mpa case continuity factor fitting response surface optimal combination continuous space identified degrees degrees mpa experimental results shown taguchi combined grey relational analysis avoid human evaluation multi objective optimization injection molding multi objective optimization implemented objectively product performance process improved effectively approach
features like high power weight ratio self lubrication heat dissipation fast control make hydraulic systems superior mechanical electric systems systems used aircraft motion simulators metal cutting universal testing machines material handling heavy industries precision operation usual employ electrohydraulic servo systems sophisticated systems proportional valve due larger deadband higher flow nonlinearities low cost rugged proportional valves together standard pid controllers result poor response tracking demand controller designed novel state estimation algorithm usual pole placement technique carefully choosing operating points one high friction cylinder another industrial grade cylinder driven separately using proportional control valve designed controller yielded better performance compare pid controller
design mechatronic systems based integration several disciplines mechanical electrical software engineering achieve integrated multidisciplinary design development process mechatronic systems attracted attention academia industry however solutions fully solve problem proposed concept multidisciplinary interface represents logical physical relationship integrating components mechatronic system components environment design mechatronic systems multidisciplinary work multidisciplinary interface model considered one effective supports aid designers achieving integrated multidisciplinary design development process paper presents multidisciplinary interface model design mechatronic systems order enable multidisciplinary integration among design team members different disciplines one hand proposed model ensures consistency interface defined designers hand helps designers guarantee different components integrate correctly interface model including three concepts classification data model compatibility rules multidisciplinary interface model implemented case study based measurement system elsevier rights reserved
mindfulness defined moment moment social awareness derived non judgmental friendly receptive attitude previous research suggested mindfulness positive effect parenting present study examined association mindfulness parent child relationship child social behavior chinese sample two hundred sixteen mothers children preschool age completed set questionnaires mindfulness parent child relationships children social behavior path analysis responses indicated mindfulness significant positive effect mother child relationship terms attachment involvement parental confidence negative effect discipline practice relational frustration mindfulness also significantly negative indirect effect children emotional symptoms conduct problems hyperactivity peer problems significant positive indirect effect children prosocial behavior results supported previous findings mindful parents involved children lives tendency aware children needs implications results discussed
compute quasinormal modes qnms metric gauge field perturbations black branes electrically magnetically charged einstein maxwellchern simons theory gauge gravity correspondence theory dual particular class field theories chiral anomaly thermal charged plasma state subjected constant external magnetic field qnms dual poles two point functions energy momentum axial current operators encode information dissipation transport charges plasma complementary gravity calculation work hydrodynamic description dual field theory presence chiral anomaly constant external find good agreement weak field hydrodynamics extend beyond weak regime intermediate regimes furthermore provide results tested thermodynamics hydrodynamics strong regime find qnms exhibiting landau level behavior become long lived large anomaly coefficient exceeds critical magnitude chiral transport analyzed beyond hydrodynamic approximation five formerly hydrodynamic modes including chiral magnetic wave
contribution seeks ascertain extent assessment economic political issues depends current weather conditions theoretical level effects weather justified two ways reconstructing influence weather person mood sentiment effect person mood assessment situations issues order test relationship weather conditions assessments empirically allbus data linked region specific weather data nice bad survey days identified influence people assessment future economic climate satisfaction democracy performance federal government examined analyses indicate positive influence nice weather negative influence bad weather assessment three issues individuals interviewed particularly sunny days average satisfaction democracy work government estimated economic climate positively persons interviewed rainy days assessed three issues negatively findings introduce interesting implications scientific commercial survey research
paper presents development central electric motoring assisted vehicle handling control system system designed electrified vehicles configured axle based electric motoring capability networking electric motor control differential brake actuation system improves performance vehicle handling control dynamic vehicle maneuvers assuring satisfactory drive comfort actuation smoothness torque vectoring scheme thus achieved coordinated vehicle yaw control brake traction control active torque compensation electrified powertrain based regular electrified vehicle architecture complexity consistency problems associated torque vectoring coordination solved additional cost proposed control technology extends capability brake based vehicle dynamic controls maneuverability enhancement retains larger stability margin dynamic handling courses well
background many studies investigated impact pediatric cognitive rehabilitation therapy crt upon intellectual functioning traumatic brain injury however relatively identified efficacious treatment school setting objective purpose present variety crt strategies would useful teacher therapist working students learning disabled traumatic brain injury tbi methods article investigates particular challenges learning result impaired cognition suggests techniques improving memory executive functioning results students learning disabled tbi face social emotional issues impact learning special therapeutic interventions necessary assist orienting setting integrating peers coping distressing emotions conclusions students tbi adapt flourish school based setting provided therapies learned strategies targeted specific needs
experimental technique developed study strength materials conditions moderate pressures high shear strain rates technique similar traditional pressure shear plate impact experiments except window interferometry used measure normal transverse particle velocities sample window interface experimental simulation results vanadium samples backed sapphire window show utility technique measure flow strength dynamic loading conditions results show strength vanadium approximately mpa pressure gpa plastic strain
study evaluates potential life cycle energy savings buildings use efficient structural roof form simulation based optimization methodology developed comparing energy requirements reinforced concrete structures based conventional flat slabs employing alternative vaulted spanning elements required quantities high embodied energy materials like steel cement may significantly reduced modeling framework combines structural thermal analyses respective quantification embodied operational energy accounts local conditions influencing material production transport code requirements structural reliability serviceability heating cooling demands year life span results clearly show potential non flat structural roof forms reduce life cycle energy consumption maximum savings embodied energy nearly cumulative life cycle energy model may implemented early design phases achieving environmentally responsible buildings elsevier rights reserved
taiwan inhabited ethnic chinese many familiar island might think also substantial number aboriginal peoples lived island millennia long chinese europeans finally japanese colonisers arrived aboriginal peoples taiwan austronesian linguistic genetic ties ethnic groups found pacific nations philippines malaysia indonesia new zealand islands oceania also madagascar indian ocean article looks challenges faced indigenous population due large part ethnic racial prejudice taiwanese reinforced national government also examines recent curriculum reforms educational discourses reject racism affirm ideals ethnic cultural freedom equality thereby exemplifying moral education truest sense
examine effects child age birth order sensitive parenting families children visited second born children months old older siblings average years older mothers showed higher levels sensitivity fathers assessments parental sensitivity increased infancy toddlerhood decreased early childhood changes parental sensitivity child age similar mothers fathers mothers fathers sensitivity levels related time however changes parental sensitivity toward firstborn second born child related suggesting parents experiences firstborn child implications sensitivity toward second born child instead child unique characteristics developmental stage seem play important role findings highlight importance considering developmental child characteristics study parenting suggest individual differences attaining developmental milestones may affect parental sensitivity
objectives describe clinical presentation radiological features outcome patients plasmacytoma temporal bone methods multicenter retrospective case series patients diagnosed plasmacytoma temporal bone comprehensive literature review previously published cases results total seven patients average age women met inclusion criteria three known history multiple myeloma common symptoms presentation included otalgia headache dizziness five presented vascular appearing middle ear mass visible otoscopy four patients established history referred presumptive diagnoses paraganglioma endolymphatic sac tumor elst average maximum tumor diameter median range commonly involved temporal bone subsites middle ear mastoid ultimately diagnosed six cases addition new cases presented herein previously published reports analyzed aggregate cases cases associated mastoid middle ear commonly involved temporal bone subsites conclusion plasmacytoma temporal bone rare clinical presentation closely mimic primary temporal bone tumors patients established history imperative high index suspicion temporal bone plasmacytoma even radiological features suggest alternate diagnosis
relationship migration gender roles received increased attention recent decades literature focused transnational migration relationships transnational internal migration gender roles internal migration widely studied paper analyse internal migration transborder experience argue indigenous women zegache engage internal migration mexico city pose greater challenges traditional gender roles community experience single young women navigating mexico capital reliance female social networks allow obtain social legitimation claiming migration experience courageousness contrast migration mexico city transnational migration although transnational migration challenges extent existing gender roles women zegache migrate transnationally often part couples within gendered social networks
paper presents distributed prony analysis algorithm using data fusion approach classic approach found kalman filter measurement update distributed optimization algorithms alternating direction method multipliers admm suitable constrained optimization problems proposed previous literature develop distributed architecture article show prony analysis non constrained least square estimation lse problem solved using classic data fusion approach compared iterative distributed optimization algorithms admm subgradient methods data fusion takes one step need iteration issue related convergence approach leads distributed prony analysis architecture requires much less demanding communication system bandwidth less compared conventional centralized prony analysis multiple channels requires bandwidth application discussed paper identify oscillation modes real world phasor measurement unit pmu data reconstruct signals key technical challenge implement prony analysis signals multiple channels difficulty identify noise characteristics channel paper method proposed identify noise covariances leads construction weighted least square estimation wise problem problem solved distributed architecture effectiveness proposed distributed prony analysis demonstrated case study results accuracy estimation improved one order compared centralized prony analysis elsevier rights reserved
computational method determine shielding effectiveness electromagnetic interference carbon nanotube cnts based nanocomposites modelling electrical properties presented specifically simulations based ant colony optimization aco implemented evaluate electrical conductivity sigma cnts used filler polymer matrix formed electrical network inside representative cuboid volume sample pseudo three dimensional percolation model developed study effects random connectivity cnts one another conductivity nanocomposites approach contact intrinsic resistances taken account tunneling resistance cnts also taken account dealing single walled cnts swcnts resistor network recognition method optimizes connective paths built using aco method conductivity subsequently computed function cnts concentration shielding effectiveness computed using conductivity data remarkable calculated values function frequency waves constant weight percent cnts agreement experimental data cnt based nanocomposites reported literature elsevier rights reserved
one important tasks computer vision online object tracking plays critical role numerous lines research drawn lot researchers attention many realistic applications paper develops novel tracking algorithm based bag local patches representation discriminative learning scheme first frame codebook learned applying kmeans algorithm set densely sampled local patches tracked object used represent template candidate samples tracking process similarities coding coefficients candidates template chosen likelihood values candidates addition propose effective model updating discriminative learning schemes capture appearance change tracked object incorporate discriminative information achieve robust matching qualitative quantitative evaluations challenging image sequences demonstrate proposed tracker performs better state art tracking methods
quantitative assessment gait patients parkinson disease important step addressing motor symptoms improving clinical management based assessment meters gait single body fixed sensor placed lower back study presents method identification step step kinematic parameters healthy controls patients early moderate stages idiopathic differences groups step step kinematic parameters evaluated understand gait impairments group moreover discriminant model groups built subset significant independent parameters based fold cross validated model discriminant model correctly classified total participants four kinematic parameters sensitivity model specificity results indicate proposed method permitted reasonably recognize idiopathic associated gait walking assessments motivates investigation clinical utility short episodes gait assessment body fixed sensors
paper presents method combining domain knowledge machine learning cdkml classifier generation online adaptation method exploits advantages domain knowledge machine learning complementary information sources whereas machine learning may discover patterns interest domains subtle humans detect domain knowledge may contain information domain present available domain dataset cdkml three steps first prior domain knowledge enriched relevant patterns obtained machine learning create initial classifier second genetic algorithms refine classifier third classifier adapted online basis user feedback using markov decision process cdkml applied fall detection tests showed classifiers developed cdkml better performance machine learning classifiers generated training dataset adequately represent real life cases learned concept accuracy initial classifier percentage points higher best machine learning classifier refinement added percentage points online adaptation improved accuracy refined classifier additional percentage points
social support important mental health well hiv positive women limited information exists specific structure composition hiv positive women support networks associations network properties mental health outcomes pilot study authors examine whether support network characteristics associated depressive symptoms survey network data collected hiv positive women via web based survey ipad application august data analyzed using multivariate linear regression models sas depressive symptoms positively associated greater number doctors woman network hiv positive network members associated less symptom reporting women reported individuals could care family support reported feeling loved less likely report disclosure stigma work highlighted detailed social network data increase understanding social support identify interventions support mental health hiv positive women significant ongoing need support peers
objective low testosterone levels may signal poor health study aimed investigate effects age abnormal metabolism sex hormones chinese male methods three hundred thirty seven elder men enrolled single center cross sectional study sex hormone levels metabolic parameters assessed results serum follicle stimulating hormone fsh luteinizing hormone sex hormone binding globulin shbg concentrations increased age free testosterone index fti testosterone secretion index tsi estradiol shbg progestin prog decreased abnormal metabolisms related androgen indices fti tsi shbg shbg even adjusting age macrovascular disease obesity overweight hyperglycemia dyslipidemia important abnormal metabolism related decreased androgen indices including shbg stepwise regression increased explanation effect respectively metabolic indices excluded abnormal metabolism indies bmi pbg correlated decrease shbg levels age positively correlated shbg levels conclusions age abnormal metabolism independently important factors associated sex hormone levels elderly chinese men mediated shbg
background approximately americans diagnosed non small cell lung cancer nsclc annually half metastatic stage disease patients historically poor survival prognosis several new therapies introduced since provide options improved outcomes objectives study quantify survival gains best supportive care bsc standard estimate impact expanded use systemic therapies clinically appropriate patients materials methods developed simulation model estimate survival gains patients metastatic nsclc survival estimates derived major clinical trials extrapolated lifetime horizon proportions patients receiving available therapies derived surveillance epidemiology end results database commercial treatment registry also estimated gains overall survival scenarios systemic therapy use increased relative current use results one year survival proportion increased mean per patient survival improved months population life years increasing treated patients increased months population life years months population life years respectively conclusion although survival remains poor metastatic nsclc relative common cancers meaningful progress per patient population level outcomes realized past years advances improved even increasing use systemic therapies substantial proportion patients suitable treatment yet currently receive bsc
novel approach tuning inverted antenna investigated using pzt materials switch elements contact using control voltage reconfigure ifa structure produces prototype reconfigurable antenna finely tuned bandwidth
human immunodeficiency virus infection acquired immunodeficiency syndrome hiv aids poor access water two primary global health issues poor access water may significantly affect families infected hiv result adverse social health consequences qualitative study used semi structured interviews understand health social outcomes families implementation water interventions rural kenya one major sub theme emerged research included effects water hiv affected family prior water interventions common adverse health effects lack nutrition water poor hygiene experienced receiving access water nutrition hygiene improved additional time gained used reinforce relationships spread awareness hiv aids study provides need based evidence access safe drinking water order decrease adverse health outcomes improve quality life hiv affected individuals
various applications global surface parametrization benefit alignment parametrization isolines principal curvature directions particularly true recent parametrization based meshing approaches directly translates shape aware edge flow better approximation quality reduced meshing artifacts existing methods influence parametrization based principal curvature directions suffer scale dependence implies necessity parameter variation try capture complex directional shape features using simple curves especially non sharp features chamfers fillets blends even organic variants thereof abstractions unfit present novel approach respects exploits nature directional feature regions detects based coherence homogeneity properties controls parametrization process accordingly approach enables provide intuitive scale invariant control parameter user also allows consider non local aspects like topology feature enabling improvements demonstrate compared previous approaches global parametrizations higher quality generated without user intervention
ensemble classification well established approach involves fusing decisions multiple predictive models similar ensemble logic recently applied challenging feature selection tasks aimed identifying informative variables features given domain interest work discuss rationale ensemble feature selection evaluate effects implications specific ensemble approach namely data perturbation strategy basically consists combining multiple selectors exploit core algorithm trained different perturbed versions original data real potential approach still object debate feature selection literature investigated conjunction different kinds core selection algorithms univariate multivariate particular evaluate extent ensemble implementation improves overall performance selection process terms predictive accuracy stability robustness respect changes training data furthermore measure impact ensemble approach final selection outcome composition selected feature subsets results obtained ten public genomic benchmarks provide useful insight benefits limitations ensemble approach paving way exploration new wider ensemble schemes elsevier rights reserved
using molecular dynamics simulations explored effect asymmetric lipids specifically contain one polyunsaturated pufa one saturated fatty acid chain phase separation heterogeneous membranes lipids prevalent neuronal membranes particularly synaptic membranes parkinson disease protein synuclein alpha found therefore explored relationship asymmetric pufa containing lipids simulations show asymmetric lipids partition liquid disordered phase canonical raft mixtures highly disordered pufa chain case membrane built mimic lipid composition synaptic vesicle pufa containing asymmetric lipids completely disrupt phase separation positively charged show partitions negatively charged lipids regardless saturation state chains additionally preferentially associates polyunsaturated fatty add tails charged neutral lipids consequence chains ability accommodate void beneath amphipathic helix article part special issue entitled lipid order lipid defects lipid control protein activity edited dirk schneider published elsevier
autoimmune myelofibrosis aimf rare entity steroid responsive bone marrow fibrosis accompanies variety autoimmune diseases particularly systemic lupus erythematosus sle rarely may occur patients autoimmune markers definable autoimmune disease primary aimf report cases two young women sle associated aimf sle aimf first patient young woman pancytopenia massive splenomegaly reticulin fibrosis marrow biopsy pancytopenia splenomegaly resolved completely within weeks treatment corticosteroids repeat marrow biopsy showed marked regression marrow fibrosis second patient young woman fever anasarca bicytopenia reticulin fibrosis marrow biopsy steroid therapy resulted rapid clinical improvement resolution pancytopenia review literature revealed total patients sle aimf reported date patients sle aimf young women sle blood cytopenia found increased bone marrow reticulin marrow biopsy steroid therapy results rapid hematological recovery regression marrow fibrosis whether aimf one several hematological complications sle represents unique distinct subset patients sle clear prospective studies longer follow needed better define prevalence clinical spectrum sle aimf
ecological city construction important part construction ecological civilization also main direction future urban development construction management economic social development important significance based connotation ecological civilization paper constructs evaluation system ecological civilization city four aspects urban economic social environmental ecological regional support made combination evaluation construction level ecological civilization city guiyang city years combined evaluation method principal component analysis results show advantages disadvantages ecological civilization guiyang city put forward series countermeasures suggestions build guiyang leading promoter future urban ecological civilization
paper dynamical adaptive ldpc coding scheme proposed order improve performance cryptographic key distillation protocol fso qkd system considering atmospheric turbulence levels may present classic channel scheme generator parity check matrices encoder modified according rytov variance values estimated classical channel order improve final secret key rate qkd system simulation results show final secret key incremented kbps kbps kbps using adaptive code rate meaning information encrypted transmitted increased addition use dynamical encoder avoids drastically reduction final secret key rate conditions classical channel considered proposal might implemented based use high speed fpga dsp commercially available
background objective safely select proper therapy ventricullar fibrillation essential distinct correctly ventricular tachycardia rhythms provided required therapy would erroneous detection might lead serious injuries patient even cause ventricular fibrillation main novelty paper use time frequency representation images direct input classifier hypothesize method allow improve classification results allows eliminate typical feature selection extraction stage corresponding loss information methods standard aha mit bih databases used evaluation comparison authors previous pseudo wigner ville pwv calculation basic preprocessing denoising signal alignment necessary order check validity method independently classifier four different classifiers used logistic regression regularization rlr adaptive neural network classifier annc support vector machine ssvm bagging classifier bagg results main classification results detection including flutter episodes sensitivity specificity sensitivity specificity ventricular tachycardia sensitivity specificity normal sinus sensitivity specificity rhythms conclusion results shows using data representations feed classifiers provide superior performance values feature selection strategies used previous works opens door used detection applications elsevier rights reserved
purpose updated estimates adolescents receipt sex education needed monitor changing access information methods using nationally representative data national survey family growth estimated changes time adolescents receipt sex education formal sources parents differentials trends adolescents gender race ethnicity age place residence results significant declines adolescent females receipt formal instruction birth control saying sex sexually transmitted disease hiv aids significant decline males receipt instruction birth control declines concentrated among adolescents living nonmetropolitan areas proportion adolescents talking parents sex education topics change significantly twenty one percent females males receive instruction methods birth control either formal sources parent conclusions declines receipt formal sex education low rates parental communication may leave adolescents without instruction particularly nonmetropolitan areas effort needed understand decline explore adolescents potential sources reproductive health information society adolescent health medicine open access article license http creativecommons org licenses
beta amyloid beta tau pathology become increasingly prevalent age however spatial relationship two pathologies remains unknown examined local region non local different region associations aggregated proteins normal older adults using tau pib beta positron emission tomography pet magnetic resonance imaging mri images local voxelwise analyses showed associations pib tracer largely temporal lobes means clustering revealed associations driven regions low tracer retention followed whole brain region region local non local partial correlational analysis calculated participant mean pib uptake values within regions interest roi pairwise roi analysis demonstrated many positive pib associations importantly strong positive partial correlations controlling age sex global gray matter fraction identified pib multiple regions association cortex temporal cortical rois also less frequent weaker positive associations regional pib frontoparietal uptake particularly temporal lobe rois uptake strongly predicted across multiple roi locations data indicate beta tau pathology show significant local non local regional associations among cognitively normal elderly increased pib uptake throughout cortex correlating increased temporal lobe uptake spatial relationship beta tau accumulation appear specific beta location suggesting regional vulnerability temporal brain regions tau accumulation regardless accumulates
aims investigate whether childmaltreatment associated life time cannabis use early onset cannabis use daily cannabis use dsm cannabis abuse young adulthood behaviour problems tobacco use alcohol use age associated cannabis use design birth cohort using linked government agency child protection data define exposure child maltreatment setting mater university queensland study pregnancy brisbane australia participants original cohort mother child pairs obtained consecutive presentations prenatal care hospital serving cross section community young people participated age years measurements exposure child maltreatment established substantiated government agency reports cannabis outcomes self report questionnaire composite international diagnostic interview cidi auto age associations adjusted range potential confounders additional adjustment carried variables measured age youth behaviour problems achenbach child behavior checklist cbcl tobacco use alcohol use findings adjustment substantiated child maltreatment associated life time cannabis use odds ratio confidence interval cannabis use prior age daily cannabis use dsm cannabis abuse dependence externalizing behaviour tobacco alcohol use age associated significantly almost cannabis outcomes internalizing behaviour associated inversely conclusions children australia documented maltreated likely use cannabis age use cannabis adult use cannabis daily meet dsm criteria cannabis dependence externalizing behaviour adolescence appears partly mediate association adult cannabis use
aim work develop software tool provides user friendly graphical interface generic configurable design order ease researcher tasks data manipulation analysis two primary targets influenced design data preparation analysis animal breeding programs usability increase applications perform important analysis methods interact users text files command lines guaiaca tool designed utility belt form two integrated assistants combined multiple analysis applications tool offers facilities collect manipulate reorganize data organize register retrieve analyses descriptors prepare activate analysis processes guaiaca execution assistant module described paper also emphasized parameters configure main data structures maintain form relationship generic interface combined analysis applications generic interface customized validated peculiarities two applications wombat mixed models intergen bayesian models several data analyses performed interface support prove generality ease installation configuration operation data sets quails breeding program used applications use integrated guaiaca wombat application illustrated analysis example prepared visualized guaiaca tool executed wombat beta version guaiaca tool windows available free charge scientific community obtained http ufpel edu gilmedeiros guaiaca
neighbour search core implementations smoothed particle hydrodynamics sph paper present efficient nlogn neighbour search method based plane sweep algorithm number sph particles resulting method dubbed pwns method totally independent grids purely meshfree capable treating variable smoothing length arbitrary particle distribution heterogenous kernels several state art data structures algorithms segment tree morton code optimized implemented simply allowing multiple lines sweep sph particles simultaneously different initial positions parallelization pwns method satisfactory speedup load balancing easily achieved pwns sph solver great potential large scale fluid dynamics simulations
previous studies exploring link social status behavior predominantly utilized measures provide information regarding toward aggression prosocial behavior directed using contextualized target specific approach study examined whether high low status adolescents behave differently toward peers varying levels status participants aged females completed measures assessing aggression prosocial behavior toward sex grademate distinct pattern findings emerged regarding likeability popularity dominance status adolescents peer targets popular adolescents reported direct aggression indirect aggression prosocial behavior toward popular peers unpopular adolescents well accepted adolescents reported prosocial behavior toward wider variety peers rejected adolescents finally compared subordinate adolescents dominant adolescents reported greater direct indirect aggression toward dominant subordinate peers results highlight importance studying target specific behavior better understand status behavior link
scaling capabilities design build test synthetic biology constructs holds great promise development new applications fuels chemical production cellular behavior engineering construct design essential component process however every designed dna sequence readily manufactured even using state art dna synthesis methods current biological computer aided design manufacture tools biocad cam adequately consider limitations dna synthesis technologies generating outputs designed sequences violate dna synthesis constraints may require substantial sequence redesign lead price premiums temporal delays adversely impact efficiency dna manufacturing process developed suite build optimization software tools boost streamline design build transition synthetic biology engineering workflows boost incorporates knowledge dna synthesis success determinants design process output ready build sequences preempting need sequence redesign boost web application available https boost jgi doe gov application program interfaces api enable integration automated customized dna design processes herein presented results highlight effectiveness boost reducing dna synthesis costs timelines
part effort expand broadcasting services based japanese sign language jsl investigating various types jsl based service delivering information people whose first language jsl report present jsl computer graphics prototype system using japan integrated broadcast broadband ibb framework hybridcast delivery jsl contents using internet enables jsl animation displayed conjunction broadcast program second screen devices smartphones tablets signals providing emergency information triggered reception event message embedded transport stream transmitted air testing showed emergency earthquake information provided jsl animation within seconds reception also showed local government evacuation instructions corresponding user residence based location information stored set displayed second screen device despite dependence drawing speed performance hardware web browser proposed system promising way provide information services jsl
promising development design datacenters hybrid network architecture consisting optical electrical elements end end traffic routed either electrical path optical path core optical switch used dynamically create optical paths pairs electrical edge switches datacenter network context joint problem bandwidth allocation placement poses new different challenges addressed yet hybrid datacenter particular foresee two issues number edge switches simultaneously reached using optical paths edge switch limited size optical switch dynamic creation optical paths potentially establish constrained optical network topology leading poor performance work abstract requests tenants virtual networks study problem embedding virtual networks hybrid datacenter formulate problem non linear optimization problem analyze complexity develop analyse three algorithms embedding dynamically arriving virtual network demands hybrid optical electrical datacenter simulations demonstrate effectiveness exploiting already established optical paths also using electrical network embedding requests virtual networks elsevier rights reserved
time delays encountered many physical systems usually threaten stability performance closed loop systems problem determining stabilising proportional integral derivative pid controllers systems perturbed delays less investigated literature study rekasius substitution employed transform system parameters new space singular frequency method revised rekasius transformed system novel technique presented compute ranges time delay stable pid controller exists stability range readily computed previous methods finally shown similar original method finite numbers singular frequencies sufficient compute stable regions space time delay controller coefficients
size installed offshore wind turbines continuously growing every year attempt make technology cost effective following trend main challenge wind turbine manufacturers reach power level however present topologies electric generators may prohibitive mass volume designed high power application paper innovative transverse flux permanent magnet tfpm generator topology disk shaped rotor presented high torque density design performed means fem software optimized order increase power factor reduce total volume power goal efficiency later improved using higher quality alloy construction iron cores proposed topology able reach torque density knm
replicated evidence indicates perinatal complications associated increased markers oxidative stress mental health problems children however fewer reports impact perinatal complications later phases development aimed investigate estimated effects perinatal complications levels lipid peroxidation psychopathology children adolescents study part high risk cohort study psychiatric disorders population composed students years age serum levels malondialdehyde product lipid peroxidation measured tbars method household interview parents caregivers conducted included inquiries perinatal history child behavior checklist cbcl parent evaluation using mini international psychiatric interview mini created cumulative risk index conceptualized individual cumulative exposure perinatal complications results indicate perinatal complications associated higher levels tbars adjusting age gender socio economic status cbcl total problems score parental psychopathology childhood maltreatment children exposed perinatal complications increase tbars levels relative unexposed group exploratory mediation analysis indicated tbars levels partially mediated association perinatal complications externalizing problems conclusion adverse intrauterine early life environment proxied cumulative exposure perinatal complications independently associated higher levels lipid peroxidation children adolescents
quality parenting children receive affects diverse range child youth outcomes addressing quality parenting broad scale critical part producing nurturing society achieve meaningful population level reduction prevalence rates child maltreatment social emotional problems directly indirectly influenced parenting practices requires adoption broad ecological perspective supporting families raise children make case adopting multilevel whole population approach enhance competent parenting describe essential tasks must accomplished approach successful effects measurable describe theoretically integrated system parenting support based social learning cognitive behavioral principles strengthened broader community supports parental participation implications policy practice discussed
secretory immunoglobulin siga one important line defense intestinal mucosal surface protect intestinal epithelium enteric toxins pathogenic microorganisms multiple factors intestinal microbiota intestinal cytokines nutrients highly involved production siga intestine recently glutamine shown affect intestinal siga production however underlying mechanism glutamine stimulates secretion intestinal siga unknown review current knowledge regarding glutamine intestinal immunity show glutamine enhanced secretion siga intestine may involve intestinal microbiota intestinal antigen sampling presentation induction pathways siga production plasma cells dependent independent pathway even transport siga altogether glutamine intestinal siga axis broad therapeutic implications intestinal siga associated diseases celiac disease allergies inflammatory bowel disease
review article summarizes role pet pet mri ovarian cancer regard diagnosis ovarian cancer presence fdg uptake within ovary postmenopausal woman raises concern ovarian cancer multiple studies show fdg pet detect lymph node distant metastasis ovarian cancer high accuracy may therefore alter management obtain better clinical outcomes although pet staging superior staging ovarian cancer role limited staging additionally fdg pet great benefit evaluating treatment response prognostic value patients ovarian cancer fdg pet also value detect recurrent disease particularly patients elevated serum levels negative inconclusive conventional imaging test results pet mri may beneficial tumor staging mri higher soft tissue contrast ionizing radiation exposure compared non fdg pet radiotracers fluorothymidine flt methionine met studied preclinical clinical studies well may play role evaluation patients ovarian cancer
water reuse systems widely implemented across globe solution water shortage freshwater contamination ongoing controversies regarding supposedly high energy cost lack sufficient data support benefits water reuse delaying expansion implementation water reuse systems south korea order clarify ambiguity regarding energy demand provide unbiased comparison water reuse alternatives conventional water supply system energy consumptions greenhouse gas emissions operation phases different water reuse facilities conventional water supply system examined average total energy consumption greenhouse gas emission conventional process calculated kwh kgcoe respectively centralized wastewater reuse systems prohibitively high energy consumptions kwh greenhouse gas emissions kgcoe decentralized wastewater reuse systems greywater reuse rainwater harvesting systems used non potable purposes comparable higher energy demands conventional process kwh adjustment although estimated greenhouse gas emissions processes lower conventional process kgcoe adjustment considering hidden environmental benefit kwh reduction contaminant release energy demand greywater reuse drops far conventional system suggesting decentralized water reuse key energy efficient water management minimal impact climate change elsevier ltd rights reserved
malassezia species opportunistic pathogenic fungi frequently associated seborrhoeic dermatitis including dandruff malassezia species lipid dependent property compensated breaking host sebum fatty acids lipases study aimed sequence analyse whole genome malassezia restricta kctc clinical isolate korean patient severe dandruff search lipase orthologues identify lipase frequently expressed scalp patients dandruff genome restricta kctc sequenced using illumina miseq pacbio platforms lipase orthologues identified comparison known lipase genes genomes malassezia globosa malassezia sympodialis expression identified lipase genes directly evaluated swab samples scalps patients dandruff found among identified lipase encoding genes gene encoding lipase homolog mres named lip study frequently expressed lipase swab samples study provides overview genome clinical isolate restricta fundamental information elucidating role lipases fungus host interaction
background excessive alcohol use associated brain damage less known brain effects moderate alcohol use previous findings indicate patients severe mental illness particularly schizophrenia vulnerable alcohol related brain damage investigated association levels alcohol consumption cortical subcortical brain structures schizophrenia bipolar disorder patients healthy controls investigated group differences association method structural magnetic resonance images acquired alcohol using participants schizophrenia patients bipolar disorder patients healthy controls mean age years men past year alcohol use assessed alcohol use disorder identification test consumption part audit general linear models used investigate associations audit score cortical thickness surface area total brain subcortical volumes results increasing audit score linearly associated thinner cortex medial dorsolateral frontal parieto occipital regions larger left lateral ventricle volume significant interaction audit score diagnostic group findings remained significant controlling substance use disorders antipsychotic medication illness severity conclusion results show dose dependent relationship alcohol use thinner cortex ventricular expansion findings present also lower levels alcohol consumption differ schizophrenia bipolar disorder patients compared healthy controls results support previous findings increased vulnerability alcohol related brain damage severe mental illness
fish aquaculture becoming important human consumption sustainable aquaculture procedures developed alternative overcome negative environmental impacts conventional aquaculture procedures wild fisheries objective contribution determine consumers expect sustainable aquaculture whether prefer sustainable aquaculture products combination qualitative research methods think aloud protocols depth interviews well quantitative methods using choice experiments face face interviews applied data collected three different cities germany results revealed sustainable aquaculture associated natural traditional local small scale production systems high animal welfare standards overall participants paid lot attention declaration origin particular fish products germany denmark preferred along local products frequently used sustainability claims aquaculture products mostly criticized imprecise participants qualitative study even though two claims tested choice experiments significant positive impact choice purchase similarly existing aquaculture specific labels certified sustainable aquaculture impact buying decision well recognized even less trusted overall consumers positive attitude towards sustainable aquaculture however communication measures labelling schemes improved increase consumer acceptance make decisive impact consumers buying behavior elsevier ltd rights reserved
paper describes series reduced scale tests unit gravity performed circular footings supported reinforced sand reinforcement multiple layers geocell investigated performance footing compared one sandy soil containing multi layered planar geotextile reinforcement comparison used geocell geotextile layers formed parent geosynthetic material characteristics lower geocell mass results show efficiency reinforcement described terms load carrying subgrade modulus enhancement decreased number layers increased tests moderate low footing settlements significant improvements bearing capacity subgrade modulus obtained application three layers geocell whole multi layered geocell reinforced soil provides effective much stiffer system capable delivering greater foundation loads subgrade modulus multi layered planar reinforced soil even less parent geosynthetic material used multi layered geocell arrangement furthermore reinforcement benefit achievable settlements small footing diameter geocell installations whereas settlements times larger needed benefit gained comparable planar geotextile system achieve comparable performances multi layered geocell requires mass geosynthetic material needed multi layered planar geotextile reinforcement depending settlement allowable multi layered geocell reinforcement requires considerably less parent geosynthetic material reducing transport perhaps supply costs size reinforcement zone required considerably smaller amount excavation backfill required also significantly reduced japanese geotechnical society production hosting elsevier
bug deduplication recognizing bug reports refer problem challenging task software engineering life cycle researchers proposed several methods primarily relying information retrieval techniques work motivated intuition domain knowledge provide relevant context enhance effectiveness attempts improve use information retrieval augmenting software engineering knowledge previous work proposed software literature context method using software engineering literature source contextual information detect duplicates bug reports relate similar subjects better chance duplicates method largely automated apotential substantially decrease level manual effort involved conventional techniques minor trade accuracy study extend work demonstrating domain specific features applied across projects project specific features demonstrated previously still maintaining performance also introduce hierarchy context capture software engineering knowledge realms contextual space produce performance gains also highlight importance domain specific contextual features cross domain contexts adding context improved accuracy kappa scores improved least per project
actively promote deep collaboration coordinated development enterprises universities research institutes great importance building innovative country paper foundation knowledge description industry university research collaborative innovation first index system performance comprehensive evaluation collaborative innovation project established neural network model performance comprehensive evaluation collaborative innovation project proposed algorithm network model designed theoretical analysis experimental results show feasibility validity model research work supplies new way performance evaluation collaborative innovation project
objective overweight obese women may avoid contraceptive methods believe associated weight gain objective study examine role weight weight perception contraceptive use study design using cross sectional data mynewoptions study analyzed contraceptive use among privately insured sexually active women aged years contraception categorized three groups long acting reversible contraceptives larcs non larc prescription methods nonprescription methods method multinomial logistic regression used model effect body mass index category weight perception contraceptive use controlling pregnancy intentions sexual behavior sociodemographic characteristics results eighty three women using larcs women using non larc prescription methods using nonprescription methods method adjusted multinomial model overweight adjusted odds ratio aor confidence interval obese women aor significantly likely use larcs compared normal weight women greater adjusted odds overweight obese women using nonprescription methods method compared non larc prescription methods finding reach statistical significance weight perception associated contraceptive use conclusion study sample overweight obese women likely use larcs normal weight women important understand weight influences women providers views contraception order better assist women individualized patient centered contraceptive decision making elsevier inc rights reserved
improve frequency stability interconnected power system including renewable energy sources control actions need robust efficient reason study proposes new optimised proportional integral derivative pid controller coordinated redox flow batteries rfbs enhancement load frequency control lfc power system concerning large penetration wind power generation pid controller parameters obtained using recently developed meta heuristic optimisation algorithm named grey wolf optimiser show effectiveness proposed control strategy interconnected two area iee japan east bus machine power system investigated simulation system dynamic responses obtained considering load change area large wind farm integration area comparative study performance proposed strategy well known optimisation techniques performed furthermore sensitivity analysis proposed controller also examined varying penetration range integrated wind farm dynamic responses obtained simulation satisfy lfc requirements addition results reveal frequency control concept based optimised pid controller coordinated rfb enhance frequency stability terms settling time peak undershoot peak overshoot
paper presents alternative theoretical classic teaching methods generally used strength materials solids mechanics introduces dynamic interactive process emphasis use esa experimental stress analysis especially strain gauges photoelasticity addition didactic practical experiments students used energy creativity develop interesting results presented experimental device measuring displacement buckling spaghetti popsicle sticks bridges stress analysis cylinder block mini baja project
study investigated relationship reading comprehension trait anxiety preoccupation reading disability school children grades mothers children trait anxiety significant direct negative relationship also mediated association preoccupation mothers preoccupation children rds direct negative association children association also mediated children trait anxiety association found mothers trait anxiety children final model explained significantly children word reading fluency trait anxiety well mothers preoccupation children rds study extends understanding multicomponential models shedding light significant role played anxiety preoccupation related factors involving children rds mothers
apremilast orally active small molecule inhibits phosphodiesterase pde clinical trials demonstrated efficacy safety psoriatic arthritis psa psoriasis established therapeutic options variable effectiveness across different domains psoriatic disease whilst biologic therapies proven significant benefit many patients patients respond others eligible tolerate biologic therapy review mechanism action pharmacokinetics clinical trial data regards efficacy safety apremilast consider new treatment may positioned treatment psa
background large sporting events raised concerns effect sexual reproductive health srh visiting resident populations host city increased demand srh services however little evidence support concerns aim study investigate commonwealth games effect service demands glasgow city wide integrated srh service methods electronic patient records city wide pharmacy data case note review used assess aspects srh included overall attendance integrated services clinic community emergency contraception prescriptions victims sexual assault acute sexually transmissible infections stis post exposure prophylaxis sexual exposure pepse prescriptions condom distribution termination pregnancy results significant decrease core sexual health attendances total acute stis emergency hormonal contraception prescriptions change pepse prescriptions number reported sexual assaults throughout city conclusions study found evidence commonwealth games placed increased demand local srh services showed increase stis emergency hormonal contraception prescriptions sexual assaults findings help service planning host cities hosting future large sporting events
usage wind energy form renewable energy becoming increasingly popular year year technology applied widely several regions world already reached maturity terms technology infrastructure cost competitiveness performance wind turbine system depends upon factors design aerodynamic performance material selection thus structural health monitoring shm become crucial evaluating performance wind turbine real time furthermore application smart material shm utilized micro energy harvester well nonetheless application shm malaysia climate wind turbine still premature especially approach biocomposites material towards blade system several issues highlighted paper vertical axis wind turbine vawf biocomposites material selection issue micro energy harvester well issues discussed compared recent finding review several recommendations suggested future studies benefiting malaysian especially application wind energy promote better green technology tomorrow elsevier ltd rights reserved
measurement ultra low parts per billion levels small molecule markers body fluids serum urine saliva involves considerable challenge view designing assay strategies sensitivity selectivity herein report first time amperometric nano bioelectrode design uniquely combines pyrenebutyric acid units stacked carboxylated multiwalled carbon nanotubes surface gold screen printed electrodes covalent attachment nad dependent formaldehyde dehydrogenase fdh designed enzyme bioelectrode offered ppb formaldehyde detection times diluted urine wide dynamic range ppb ppm fourier transform infrared raman electrochemical impedance spectroscopic characterizations confirmed successful design fdh bioelectrode flow injection analysis provided lower detection limit greater affinity formaldehyde apparent ppm compared stirred solution method apparent ppm selectivity assays revealed bioelectrode selective toward formaldehyde moderate crossreactivity acetaldehyde similar negligible cross reactivity toward propanaldehyde acetone methanol ethanol formaldehyde indoor pollutant studies indicated neurotoxic characteristics systemic toxic effects compound upon chronic high doses exposure moreover reported chromatography mass spectrometry methods identified elevated urine formaldehyde levels patients bladder cancer dementia early stages cognitive impairments compared healthy people results demonstrate pyrenyl carbon nanostructures based fdh bioelectrode design represents novelty simplicity enzyme selective electrochemical quantitation small formaldehyde broader applicability presented approach small molecule markers feasible requires design appropriate marker specific enzyme systems receptor molecules elsevier rights reserved
teaching students code classrooms considered one major keys promoting engineering education future potentially enhance competency computational skills students adhere better learning outcomes higher education success promoting coding education integrating school curriculum depends perceptions teachers headmasters schools well believe coding education prepare innovative teaching learning exploratory research study reports results large scale quantitative questionnaire surveying primary secondary schools hong kong computer programming regulated compulsory course curriculum questionnaire aims investigate school belief coding education practical challenges integrating regular school curriculum results show trend local schools promoting coding education positive perceptions teaching learning however teaching challenges also mentioned survey waiting solutions lack teachers training unified curriculum therefore empirical experiences schools set forth future research direction design implementation coding education classrooms hong kong also globe
background adults autism spectrum disorder asd encounter many difficulties finding accessing health care services despite studies considered health service use patterns adults asd without intellectual disability objectives current study examines diverse range medical mental health services supports well adults personal experiences accessing using services barriers service use reported unmet service needs methods forty adults ages years asd without completed surveys every two months health service use total months bivariate analyses conducted understand individual demographic clinical factors associated rate service use satisfaction services barriers health care results results indicated beyond family doctor commonly used services dentistry individual counseling psychiatry individuals medical problems experienced significantly barriers service use medical mental health problems less satisfied services conclusions findings highlight challenges adults asd without face accessing appropriate quality services meet needs particularly complex medical mental health issues service providers must strive provide adequate health care population may become distressed needs left unmet elsevier inc rights reserved
background oral misoprostol administered trained health workers effective safe preventing postpartum haemorrhage pph interest expanding administration misoprostol non health workers including task shifting pregnant women however use misoprostol preventing pph home births remains controversial due limited evidence support self administration leaving hands non health workers study aimed determine antenatally distributing misoprostol pregnant women self administer home birth reduces pph methods february march conducted stepped wedge cluster randomized trial six health facilities central uganda women weeks gestation attending antenatal care eligible women control arm received standard care intervention arm offered mcg misoprostol swallow immediately birth baby oxytocin available primary outcome pph drop postpartum maternal haemoglobin lower prenatal analysis intention treat cluster level used paired tests assess whether mean difference control intervention groups statistically significant results eligible women consented participate control intervention arms respectively two thousand fifty seven participants successfully followed delivered outside health facility significant difference study group number women received uterotonic birth control intervention mean difference confidence interval woman took misoprostol baby birth shivering fever control arm compared intervention arm mean difference slight non significant reduction percentage women drop control arm intervention arm mean difference similarly significant difference groups primary outcome women delivered home control intervention mean difference conclusion study unable detect significant reduction pph following antenatal distribution misoprostol
purpose sleep disorders affect great percentage population diagnosis disorders usually made polysomnography paper details development new software carry feature extraction order perform robust analysis classification sleep events using polysomnographic data software called psgminer tool visualizes processes classifies bioelectrical data purpose program provide researchers platform test new hypotheses creating tests check correlations available commercially available software software freely available gpl license method psgminer composed number diverse modules feature extraction annotation machine learning modules accessible main module using software possible extract features polysomnography using digital signal processing statistical methods perform different analyses features classified use five classification algorithms psgminer offers architecture designed integrating new methods comparison existing methods automatic scoring available almost commercial psg software inherently available program though implemented two different methodologies machine learning algorithms similar software focuses certain signal event composed small number modules expansion possibility software introduced handle polysomnographic signals events conclusions software simplifies processing polysomnographic signals researchers physicians experts computer programming find correlations different events could help predict oncoming event sleep apnea software could also used educational purposes elsevier ltd rights reserved
efficient power generation techniques used modern aircraft described form high voltage variable frequency starter generator advantages enabling electric aircraft discussed machine design aspects system obtained detailed analysis output equation high speed rotating machine case studies taken varying various parameters equation results obtained compared graphically new important conclusions derived study summarized
background understanding views constitutes healthy diet diverse populations may inform design culturally tailored behavior change interventions objective study describe perspectives healthy eating among chinese american young adults identify similarities differences groups methods chinese american undergraduate students changsha hunan china honolulu hawai composed one two paragraph responses following prompt phrase healthy diet mean researchers used content analysis identify predominant themes using dedoose version sociocultural research consultants llc los angeles three researchers independently coded essays grouped codes similar content team identified themes sorted discussion two researchers deductively coded entire data set using eight codes developed initial coding calculated total code counts group participants results chinese students mentioned physical outcomes maintaining immunity digestive health timing eating regular meals greater intake day night emphasized american students described balancing among food groups balancing consumption exercise physical activity considered essential students also stated food components sugar salt fat avoided large quantities similarities included principles moderation fruits vegetables nutritious differences included foods restricted meal timing groups emphasized specific foods guiding dietary principles several distinctions viewpoints emerged conclusions diverse views may reflect food related messages participants exposed media educational systems respective countries future studies may examine themes may typically addressed nutrition education programs diverse populations young adults gaining greater knowledge ways healthy eating viewed allow development interventions sensitive traditional values predominant views health various groups
study investigated whether pattern behavior associated popularity usa also found indonesia participants years grade years muslim students west java indonesia data obtained adolescents peers teachers social preference popularity positively associated prosocial behavior number mutual friends whereas social preference positively associated academic achievement negatively associated aggression popularity positively associated aggression tobacco use patterns association similar found united states indonesian society highly hierarchical popularity structures may build upon stratifications
purpose unclear physical therapists florida currently treat people knee osteoarthritis whether current best evidence used clinical decision making methods conducted survey physical therapists florida assessed perceived effectiveness actual use physical therapy interventions quantified association actual use interventions different characteristics physical therapists results total physical therapists completed survey respondents perceived therapeutic exercise education effective effective interventions least perceived effective effective electrotherapy wedged insole ultrasound physical therapists followed principles evidence based practice likely use therapeutic exercise education less likely use ultrasound electrotherapy results also indicated older physical therapists likely use ultrasound electrotherapy kinesiology tape ice conclusions line clinical guidelines physical therapists use therapeutic exercise education treat people knee osteoarthritis however interventions lack scientific support electrotherapy ultrasound still used modifiable therapist characteristic adherence evidence based practice positively associated use interventions supported scientific evidence
repeated depth first traversal trees common algorithmic pattern important set applications diverse domains cosmological simulations data mining computer graphics applications operate massive data sets often necessary distribute trees process data work introduce spirit runtime system ease writing distributed tree applications spirit automates challenging tasks tree distribution optimizing communication parallelizing independent computations common algorithmic pattern tree traversals exploited effectively schedule parallel computations improve locality result pipeline parallelism distributed traversals identified complemented load balancing locality enhancing message aggregation optimizations evaluation spirit tree traversal point correlation shows scalable system achieving speedups upto node process system compared node baseline configuration also find spirit results substantially less communication achieves significant performance improvements implementations distributed graph systems
ethnopharmacological relevance kigelia africana quintessential african herbal medicinal plant pan african distribution immense indigenous medicinal non medicinal applications plant use traditionally remedy numerous disease use wounds healing rheumatism psoriasis diarrhea stomach ailments also use aphrodisiac skin care aim review present review aims compile date review progress made continuous pharmacological phytochemistry investigation africana corresponding commercial pharmaceutical application findings ultimate objective providing guide future research plant method scholarly information needed paper predominantly sourced electronic search engines google google scholar publishing sites elsevier sciencedirect bmc pubmed scientific database sites chemicals chemspider pubchem also online books results pharmacological investigations conducted confirm anti inflammatory analgesic antioxidant anticancer activity extract different parts plant bioactive constituents found present parts plant far approximately compounds characterized different part plant iridoids naphthoquinones flavonoids terpenes phenylethanoglycosides major class compounds isolated novel compounds potent antioxidant antimicrobial anticancer effect verbascoside verminoside pinnatal among others identified commercial trade africana boosted las decades effect maintenance skin recognized resulting handful skin formulations market conclusions pharmaceutical potentials africana recognized witness surge research interest however till date many traditional medicinal uses investigated scientifically probing existential researches pharmacological activity recommended end goal unravelling pharmacodynamics pharmacokinetics clinical relevance possible toxicity side effects extract active ingredients isolated elsevier ireland ltd rights reserved
excessive consumption alcohol well established risk factor atrial fibrillation however effects moderate alcohol drinking remain elucidated study designed determine effects moderate ethanol ingestion atrial fibrillation electrophysiological mechanisms acetylcholine induced canine mouse models moderate ethanol prevented generation persistence prolonging latent period shortening duration action potential duration apd remarkably prolonged concentration range ethanol guinea pig atrial myocytes ultra rapid delayed rectified potassium currents markedly inhibited ethanol concentration dependent manner ethanol could inhibit rapid delayed rectifier potassium currents herg ethanol affect inward rectifier potassium currents kir collectively present study provided evidence moderate ethanol intake prolong apd atrial myocytes inhibition herg contributed preventing development duration elsevier inc rights reserved
focus groups examined development maintenance eating disorder females type diabetes eating disorder quotes qualitative data summaries provide rich insights understanding type diabetes increased risk eating disorders content analyses revealed five themes pertinent dual diagnosis feeling different difficulty control coping body image feelings quality life four themes relevant eating disorder development findings support early identification risk inform interventions mitigate development eating disorder
matrix metalloproteinase mmp involved pathophysiology asthma mainly asthma associated airway remodeling exhaled breath condensates ebc asthmatics contain increased amounts mmp activity higher healthy controls increased activity mmp may originate excessive production activation may also result variations mmp structure determined single nucleotide polymorphisms snps pilot study aimed assess possible influence two functional mmp polymorphisms enzymatic activity mmp measured ebc asthmatic children concentration activity mmp analyzed ebc children allergic asthma using specific standard elisa novel immunoenzymatic activity assay snps mmp assessed using real time pcr based genotyping test found mmp concentration breath condensates children stable asthma slightly higher elisa activity assay moreover results activity toamount ratio revealed relationship presence specific mmp gene variants observation suggests least patients mmp hyperactivity may result genetic predisposition determined polymorphic variants mmp gene moreover supports previous reports postulating significance mmp pathogenesis asthma however issue still requires studies
systems hysteretic tuned mass dampers proposed multi mode flutter mitigation long span suspension bridges performance nonlinear absorbers systematically compared classical damped linearly viscoelastic absorbers equations motion ensuing linearized parametric structural model suspension bridge coupled equations governing dynamics passive nonlinear control system time dependent aerodynamic loads obtained quasi steady nonlinear formulation unsteady indicial theory equations controlled aeroelastic system reduced employing faedo galerkin method numerical simulations performed investigate effectiveness vibration absorbers system comparing onset flutter post flutter behavior without control devices corresponding responses obtained multiple absorbers installed elsevier ltd rights reserved
microgrids interconnection main grid gaining importance nowadays usually inverters acts power interface renewable energy resources main electrical network paper focuses design simulation simple easy implement controller operation inverter matlab simulink environment controller enables microgrid operate grid parallel well standalone mode phase locked loop pll used lock grid frequency phase simple effective quasi active islanding detection algorithm used transition modes simulation shows effectiveness algorithm combined control strategy minimizing non detection zones different loading conditions simulations also show algorithm ability distinguish islanding event load variations
motivation study provide new information researcher based field study networking systems cyber crime becoming widespread imperative improve measures used counteract threats various research gaps based awareness cyber security different methods used enhancing troubleshooting network security research area otter many opportunities justice served creating awareness making cyber space secure area creating new business niche based security hence study network security read research papers published documents retrieved online caida ieee along computer journals articles research papers summarized different research gaps help enlighten researcher topic network security therefore researchers take initiatives come solutions issues raised paper
introduction myelofibrosis philadelphia chromosome negative myeloproliferative neoplasm associated debilitating constitutional symptoms progressive splenomegaly cytopenias ruxolitinib jak inhibitor currently drug approved treatment patients intermediate high risk rationale even limited clinical data supporting use ruxolitinib lower risk patients although yet validated randomized controlled trial areas covered examine rationale using ruxolitinib lower risk patients including survival data comfort comfort specific patient populations may derive clinical benefit future impact molecular analysis risk stratification treatment additionally consider potential risks associated earlier intervention ruxolitinib therapy expert commentary although exists rationale use jak inhibitor therapy lower risk patients eagerly await results ongoing randomized controlled trial addressing question recommending wider use community setting
background leptin adiponectin resistin may play important role development lipodystrophy hiv aids patients aim study correlate levels leptin adiponectin resistin hiv aids patients without lipodystrophy non well subgroups lipoatrophy lipohypertrophy mixed fat redistribution mfr non patients methods cross sectional study hiv aids patients serum levels leptin adiponectin resistin measured associations adipocytokine levels metabolic variables estimated spearman correlation analysis covariance bootstrapping method used examine relationship adiponectin leptin lipodystrophy categories results observed patients patients mfr significant differences regarding leptin adiponectin resistin levels non patients observed patients significantly higher levels leptin adiponectin comparison non patients respectively within group patients significantly lower levels leptin mfr patients significantly higher levels adiponectin mfr correlation adiponectin remains significant subgroup adjustment age body mass index cystatin plasminogen activator inhibitor pai interferon gamma ifn gamma conclusions adiponectin leptin levels differ significantly patients non patients well subgroups adiponectin may useful marker hiv aids patients
current study provides additional information nomological networks personality dimensions associated triarchic conceptualization psychopathy boldness meanness disinhibition patrick analyses based sample college students women evaluated correlations measures triarchic constructs measures facets domains five factor model ffm also evaluated associations triarchic constructs measures self esteem narcissism aggression antisocial behavior tested whether triarchic measures increment measures ffm predicting variables replicated extended previous studies concerning correlates boldness meanness disinhibition also found evidence measures triarchic dimensions incremented measures ffm especially considering self reported antisocial behavior
understanding local inflow conditions wind turbine blade operating wind turbine understanding aerodynamic variations help predict loads turbine turbine blades generally designed two dimensional steady approach however real wind conditions highly three dimensional unsteady detailed measurements common validating aerodynamic models aim theoretical experimental study build calibrate install test compact blade five hole pressure probe system used retrieve measurements wind tunnel calibration five hole pressure probe successfully completed using automated traversing system degrees range degrees increments error analysis showed multi zone pressure coefficient data reduction approach suitable application approach extends measurable local inflow angles degrees also allows reference pressure differential pressure readings new data acquisition system daq internal rotating small wind turbine blade section developed space limitations resulted custom built daq contained dimensions included among others five pressure transducers printed circuit board bit analog digital converter arduino microcontroller bluetooth transceiver transmit data wirelessly main computer new blade section designed printed way daq instrumentation could easily accessed time acceptable structural solidity series tests conducted diameter wind turbine large scale wind tunnel order assess correct functioning probe system expected inflow measurement obtained turbine operating yawed conditions showed periodically oscillating inflow vector period variation period rotor rotation
development precision agriculture demands high accuracy efficiency cultivated land information extraction new means monitoring ground recent years unmanned aerial vehicle uav low height remote sensing technique flexible efficient low cost high resolution widely applied investing various resources based novel extraction method cultivated land information based deep convolutional neural network transfer learning dtcle proposed first linear features roads ridges etc excluded based deep convolutional neural network dcnn next feature extraction method learned dcnn used cultivated land information extraction introducing transfer learning mechanism last cultivated land information extraction results completed dtcle ecognition cultivated land information extraction ecle location pengzhou county guanghan county sichuan province selected experimental purpose experimental results showed overall precision experimental image extracting cultivated land dtcle method respectively overall precision ecle respectively accuracy dtcle equivalent ecle also outperformed ecle terms integrity continuity
cantilever failure involves rapid channel widening delivers large volume sediment channel important understand mechanism river engineering point view different types riverbank failures investigated several previous studies works limitations understanding complex mechanisms cantilever failure regarding coupling fluvial erosion failure experiments thus carried assess underlying mechanisms cantilever failure using three types cohesive materials classified basis percentages silt clay content experiments showed fluvial erosion lower part cohesive riverbanks progressively undermines upper part initial stage cantilever failure tension cracks develop upper surface cohesive riverbanks beam failure occurs thereafter mathematical model cantilever failure also developed model uses triple grid approach simulate behaviour cantilever within framework fluvial erosion cantilever subsequent failure simulated results show good agreement experimental results terms spatial averaged bank width water level along cohesive riverbanks
objective characterize cohort patients interstitial lung disease ild assess utility previously developed mortality staging systems gender age lung physiology gap ild gap methods patients ild seen mayo clinic identified manually screened study inclusion disease characteristics pulmonary findings including high resolution pulmonary function testing evaluated survival estimated using kaplan meier methods gap ild gap models evaluated using statistics standardized incidence ratios results study included patients associated ild caucasian females never smokers mean age ild diagnosis years median time diagnosis ild years range median follow years range age disease duration low initial diffusing capacity carbon monoxide predictive premature mortality multivariate modelling sex smoking status obstructive lung disease seropositivity erosive disease associated mortality year survival rate survival differ usual interstitial pneumonia non specific interstitial pneumonia organizing pneumonia gap model performed well cohort discrimination calibration statistic standardized incidence ratio conclusion large single centre cohort patients ild patients seropositive history smoking ild commonly occurred diagnosis mortality high differ among types gap model may useful assessing mortality risk
limited information available optimal cement thickness monolithic zirconia crowns study designed evaluate stress distribution posterior monolithic zirconia crowns different cement thicknesses masticatory force maximum bite force using three dimensional finite element analysis prepared unprepared mandibular right first molar models scanned exported computer aided design system solid models monolithic zirconia crowns cemented prepared teeth generated four models fabricated applying different cement thicknesses solid models imported finite element analysis software meshed tetrahedral elements four three dimensional finite element models simulated masticatory force maximum bite force vertical axial angular degrees horizontal loads points vertical load points loaded respectively stress distribution varied different cement thicknesses directions applied loads monolithic zirconia crowns cement thicknesses exceeding wider distributions peak maximum principal stress loading conditions monolithic zirconia crowns stress concentrations occlusal surfaces cement layers stress concentrations cervical areas thicker cement layers associated concentrated stresses buccal lingual cervical areas test results show cement thickness plays essential role success monolithic zirconia restorations terms reducing cement wash cement thickness recommended monolithic zirconia crowns authors published elsevier ltd open access article license
computer programming essential engineering education developing programming education support tool pgtracer order facilitate learning process computer programming pgtracer utilizes fill blank question composed pair source program trace table propose set feedback functions students paper pgtracer automatically collects learning log students fill blank feedback functions provide various analysis result collected log students easily understand achievement level weak points many students highly appreciate feedback functions experimental evaluation functions
background many people seek alternative treatments reduce stress manage anxiety counsel people appropriately physicians need understand current evidence recognize value defects facts objective review effect tai chi interventions improvement mental health learn lessons current evidence various clinical studies methods literature search performed identify research studies assessed tai chi mental health benefits selected studies classified according research design outcome measures results qualitatively assessed based tai chi significant influence mental health areas mood stress anxiety level results screening citations mentioned tai chi intervention found clinical studies included least one outcome measure mental health testing system included mental health component results show low evidence recommending tai chi intervention patients seek improvement mental health despite many positive effects tai chi practice mood anxiety found different clinical trials conclusion considering fact tai chi gentle exercise well suited people various physical capabilities especially elderly health care providers may consider recommending people mental health issues seek alternative treatment besides routine medical care nonetheless clinicians aware limitations due incomplete understanding tai chi intervention better evidence stronger clinical trial designs needed investigate tai chi role improving mental health
recent findings elucidated roles mitochondrial uncoupling proteins ucps neuronal plasticity resistance metabolic oxidative stress ucps induced bioenergetic challenges caloric restriction exercise may protect neurons dysfunction degeneration pharmacological uncoupler dinitrophenol dnp prescribed people treatment obesity stimulates several adaptive cellular stress response signaling pathways neurons including involving brain derived neurotrophic factor bdnf transcription factor cyclic amp response element binding protein creb autophagy preclinical data show low doses dnp protect neurons improve functional outcome animal models alzheimer parkinson diseases epilepsy cerebral ischemic stroke repurposing dnp development novel uncoupling agents hormetic mechanisms action provide opportunities new breakthrough therapeutic interventions range acute chronic insidious neurodegenerative neuromuscular conditions paradoxically body weight preserving doses published elsevier inc behalf alzheimer association
streptococcus uberis one prevalent pathogens causing clinical subclinical mastitis worldwide among bacterial factors involved intramammary infections caused organism uberis adhesion molecule suam one main virulence factors identified molecule involved uberis internalization mammary epithelial cells lactoferrin binding objective study evaluate suam properties potential subunit vaccine component prevention uberis mastitis epitope prediction analysis suam sequence used identify potentially immunogenic regions since regions detected along gene criterion allow selecting specific region potential immunogen hence four fractions suam comprising protein cloned expressed every fraction elicited humoral immune response mice predicted bioinformatics analysis suam generated antibodies highest recognition ability towards suam native protein moreover antibodies suam produced highest proportion internalization inhibition uberis mammary epithelial cells conclusion suam immunogenic functionally relevant regions identified allowed propose suam lfr potential candidate subunit vaccine uberis mastitis prevention elsevier ltd rights reserved
specific research informed models family therapy developed range adolescent problems include brief strategic family therapy bsft functional family therapy fft multisystemic therapy mst multidimensional family therapy mdft multidimensional treatment foster care mtfc conduct disorder drug misuse family focused cognitive behaviour therapy anxiety disorders depression attachment based family therapy abft depression family focused therapy adjunct pharmacological therapy bipolar disorder abft youth nominated support team dialectical behaviour therapy dbt combined multifamily therapy self harm maudsley model family therapy eating disorders psychoeducational family theory psychosis approaches aim reduce individual familial risk factors exacerbate adolescent problems enhance protective factors promote resilience recovery psychological difficulties
recent years increased interest understanding cognitive processes playa role pathogenesis obsessive compulsive disorder ocd one cognitive factor received little attention rumination rumination defined tendency repetitively analyze ones problems feelings distress implicated development maintenance several mood anxiety related disorders thus primary aim current study examine role rumination ocd symptoms using unselected treatment seeking sample multiple regression analyses revealed significant association rumination unacceptable thoughts neutralizing domain ocd findings remained significant even accounting relevant related construct particular negative affect findings support growing body literature establishing rumination transdiagnostic risk factor clinical experimental research needed confirm findings expand knowledge metacognitive models ocd elsevier ltd rights reserved
report adamantyl cyanoguanidine compounds based hybrids adamantyl amide scaffold reported astrazeneca cyanoguanidine scaffold reported abbott laboratories compound displayed five fold greater inhibitory potency lead compound pore formation interleukin beta release assays treated mice displayed antidepressant phenotype behavioral studies sar study provides proof concept hybrid compounds help development antagonists elsevier masson sas rights reserved
previous research indicated parents impact minor children health behaviors adult children sel frated health psychological well however little known long term consequences parent child relationship adult children substance smoking levels low moderate alcohol use adult children age present study uses growth curve analysis longitudinal survey data americans changing lives examine multiple dimensions parent child tie influence adult children substance use findings show contact mothers adulthood health enhancing effect sons smoking fathers support related decline alcohol use sons daughters also increase smoking sons findings strain parents complex suggesting ways adult children cope manage strain parents may result multiple pathways substance use study raises new questions whether family ties good bad health calls multifaceted view long lasting parent child tie spotlight need look parent child relationship dynamic social tie changes life course consequences health adulthood published elsevier ltd
classical strength materials beams represented first two terms asymptotic expansion solution navier equations method asymptotic expansions respect inverse slenderness beam permits obtain approximate solution saint venant problem elasticity second order displacement field obtained sum series general term nth order solution differential recursive system presently propose general way solving kind system exact solution given explicitly case slender field beam
number security protocols designed mobile transactions using near field communication technology last years however component architectures protocols rarely implemented java evaluation paper briefly discuss previously proposed mobile transaction authentication protocol extend work presenting java implementation implementation provides detailed analysis based number factors respect security considerations protocol particularly design stage thus provides broad verification well step step evaluation protocol specifications implementation point view
background firearms major cause injury death sought determine prevalence movie scenes depicted firearms verbal firearm safety messages context health outcomes firearm scenes association motion picture association america ratings firearm scene characteristics methods ten top revenue grossing motion pictures selected year descending order gross revenues data firearm scenes collected movie coders using dual monitor computer workstations real time collection tools results seventy movies scenes firearms majority movies firearms rated firearm scenes accounted screen time movies firearms among firearm scenes crime illegal activity involved deaths occurred injuries occurred verbal reference safety made conclusions depictions firearms top revenue grossing movies common safety messages exceedingly rare major motion pictures present used opportunity education firearm safety
association analysis whole genome sequencing wgs studies propose efficient fast spatial clustering algorithm compared existing analysis approaches wgs data define tested regions either sliding consecutive windows fixed sizes along variants meaningful grouping nearby variants consecutive regions advantage compared sliding window approaches number tested regions likely smaller comparison consecutive fixed window approaches approach likely group nearby variants together given existing biological evidence disease associated mutations tend physically cluster specific regions along chromosome identification meaningful groups nearby located variants could thus lead potential power gain association analysis algorithm defines consecutive genomic regions based physical positions variants assuming inhomogeneous poisson process groups together nearby variants parameters estimated locally algorithm takes differing variant density along chromosome account provides locally optimal partitioning variants consecutive regions implementation algorithm provided discuss theoretical advances algorithm compared existing window based approaches show performance advantage introduced algorithm simulation study application alzheimer disease wgs data analysis identifies region itgb gene potentially harbors disease susceptibility loci alzheimer disease region based association signal itgb replicates independent data set achieves formally genome wide significance software implementation implementation algorithm available
studies described article explore influence emphasized determinant cooperative behavior social dilemmas affected third parties two experiments examined effect characteristics third parties individual cooperative behavior social dilemmas identified mechanisms associated relationships study demonstrated third party need affects individual cooperative behavior tested prosocial motivation intra group trust mediators relationship study provided elaboration demonstrating individual cooperative behavior reduced needy third party low reliability showing prosocial motivation intra group trust mediated relationship research connects literatures individual cooperation social dilemmas relational job design demonstrates third parties influence individuals cooperative behavior
explore effect behavioral realism reciprocal self disclosure computer interviewers social responses human users simulated psychotherapeutic counseling interactions investigate subject designed factorial subjects experiment involving three conditions behavioral realism high realism low realism audio displaying behavior three conditions reciprocal self disclosure high disclosure low disclosure disclosure measured users feelings social presence copresence social attraction emotional credibility rapport perception quality users responses embarrassment self performance emotional state panas perception interaction partner person perception self reported self disclosure speech fluency pause fillers incomplete words verbal self disclosure observed contradictory outcomes users subjective reports however results objective data analysis demonstrated users disclosed greater verbal self disclosure medium level intimacy interacting computer interviewers displayed high behavioral realism high self disclosure users also delivered fluent speech interacting computer interviewers displayed high behavioral realism elsevier ltd rights reserved
one fourth global mortalities still caused microbial infections largely due development resistance conventional antibiotics among pathogens resurgence old infectious diseases emergence hundreds new infectious diseases lack funds resources discovery new antibiotics necessitates search economic effective alternative antimicrobial agents metal metal oxide nanoparticles including silver zinc oxide exhibit remarkable antimicrobial activities pathogens hence one propitious alternative antimicrobial agents engineered nanomaterials approved regulatory agencies usfda korea fiti use antimicrobial agents supplementary antimicrobials food packaging skin care products oral hygiene fortifying devices prone microbial infections nevertheless detailed studies molecular biochemical mechanisms underlying antimicrobial activity missing take full advantage emerging technology selective antimicrobial activity nanoparticles pathogens studied optimization nanomaterials functionalization increase efficacy biocompatibility also required urgent vivo studies toxicity nanomaterials realistic doses also needed clinical translation elsevier rights reserved
parkinson disease highly heterogeneous disorder genetic factors likely contribute clinical variability including susceptibility cognitive impairment dementia monogenic forms parkinsonism show distinct cognitive profiles yet less known impact common genetic variants cognition sporadic parkinson disease systematic review literature current results genetic association studies cognitive outcomes summarized prospects challenges future studies discussed literature searches pubmed database performed studies using statistical methods assess associations genetic variation cognitive outcome parkinson disease patients included candidate loci investigated several studies current evidence summarized discussed sixty one articles meeting inclusion criteria identified highly heterogeneous respect study design size cognitive outcome measures gba mutations negative impact cognition whereas lrrk associated disease may milder cognitive phenotype idiopathic parkinson disease common variants reported results partly conflicting even across larger studies evidence suggest potential effect apoe mapt comt snca cognitive outcomes future investigations aim collect high quality cognitive data standardized way allows direct comparison across studies large scale meta analysis linking genetic profiles cognitive outcomes may important clinical impact facilitating stratification patients clinical trials ultimately individualized treatment parkinson disease
mechanical functional performance nonwoven fabric critically depends fibre architecture fibre laydown process plays key role controlling architecture fibre dynamic behaviour laydown studied finite element model describes role parameters defining area covered single fibre deposited conveyor belt path taken fibre described terms radius gyration characterises area covered fibre textile spectrum curvature describes degree fibre looping function arc length starting deterministic idealised fibre curvature spectra stochastic monte carlo simulations undertaken generate full nonwoven web samples reproduce uniformity fibre density novel image analysis technique allows measurement uniformity real spunbonded nonwoven samples images textiles used confirm validity model shown main parameter governs fibre density uniformity ratio fibre spinning velocity velocity conveyor belt fibre oscillations prior deposition play secondary role
applications manipulate sparse data structures contain memory reference patterns unknown compile time due indirect accesses exploit parallelism improve locality applications prior work developed number run time reordering transformations rtrts paper presents sparse polyhedral framework spf specifying rtrts compositions thereof algorithms automatically generating efficient inspector executor code implement transformations experimental results indicate performance automatically generated inspectors executors competes performance hand written ones optimization done elsevier rights reserved
seven baladi goats sexes months old used describe distribution pattern alpha smooth muscle actin asma vimentin vim reticulum omasum study carried using avidin biotin immunoperoxidase method immunostaining restricted basal cells layer epithelia reticulum omasum suggesting importance epithelial cells proliferation keratin biosynthesis immunostaining asma detected smooth muscle cells reticular folds omasal lamiae muscularis reticulum omasum indicating critical role asma muscular motility widespread distribution vim immunostainings epithelia fibroblasts lamina propria submucosa endothelia blood vessels supports importance vim intermediate filament protein detection vim glial cells enteric plexuses indicates supportive role nervous control reticulum omasum overall immunohistochemical study revealed non significant differences expression asma vim reticulum omasum study thus verifies important roles asma vim structure function reticulum omasum baladi goats
proliferation information technologies diversity problem domains heavily rely software tool applications promote computer supported cooperative work challenging discipline drives development process contemporary future engineering methods standards tools consequently particular domain expertise engineering scientific fields emerged demanding advanced skills deeper domain knowledge essential role architectural design urban planning enable forward looking approach building facility creation construction engineering expresses routine primarily transition phase transforms ideas sustainable urban artifacts role appears combination backward downward looking process product three domains highly cooperative context environmental engineering currently available software tools support domains far simple several recent software engineering studies suggest instead developing complex one solution federation orchestration several related simple methods tools seems promising article discuss basic domain cooperation aspects suggest extensible orchestration framework exof model may support verify exof simulation orchestration potential used architectural model orchestrate different software tools performing urban blocks daylight illumination simulation different urban block morphology models exact simulation used normalized sun exposition data city novi sad serbia also presented illustration methodology modeling orchestration potential exof selected case study together results obtained typical models selected urban block morphology patterns elsevier rights reserved
geotextiles produced meandrically arranged kemafil ropes prepared ropes produced textile waste materials woollen nonwoven nonwoven blend recycled fibres ropes arranged segments used protection bank deep drainage ditch reinforcement shallow roadside ditch clay ground geotextiles installed ground behaviour one vegetation season observed stated heavy rains meandrically arranged ropes form system micro dams slow stream water flowing surface ditch bank well stream flowing along ditch geotextiles installed ditch banks eliminate formation erosive channels protect banks sliding geotextiles absorb water ensures retention water flowing along ditch due enhanced soil water holding capacity geotextiles protect grass seeds washed facilitate development protective vegetation materials used production ropes reveal sufficient resistance biological degradation slow biodegradation materials enable keeping protective potential geotextiles least one vegetation season elsevier ltd rights reserved
using intracranial local field potential lfp recordings patients parkinson disease undergoing deep brain stimulation dbs explored electrophysiological activity subthalamic nucleus stn response emotional stimuli auditory modality previous studies focused influence visual stimuli end recorded lfps within stn response angry happy neutral prosodies patients undergone implantation dbs electrodes observed specific modulation right stn response anger happiness opposed neutral prosody occurring around post onset later around post onset anger around post onset happiness taken together previous reports modulated stn activity response emotional visual stimuli present results appear confirm stn involved emotion processing irrespective stimulus valence sensory modality elsevier inc rights reserved
peripheral cell lymphomas ptcls aggressive non hodgkin lymphomas generally poor outcomes following standard therapy candidate therapeutic targets identified date retinoic acid receptor alpha rara transcription factor modulates cell growth differentiation response retinoids retinoids used treat cutaneous cell lymphomas ctcls mechanism action role rara ctcl mature cell lymphomas remain poorly understood identifying ptcl rara mutation sought characterize role rara cell lymphoma cells overexpressing wild type rara rara significantly increased cell growth rara low cell lines rara knockdown induced arrest decreased expression cyclin dependent kinases cdk rara high cells retinoids tamibarotene trans retinoic acid caused dose dependent growth inhibition arrest cdk regulation genes regulated transcriptome data enriched cell cycle transition finally rara overexpression augmented chemosensitivity retinoids conclusion rara drives cyclin dependent kinase expression transition cell growth cell lymphoma synthetic retinoids inhibit functions dose dependent fashion effective cells high rara expression indicating rara may represent therapeutic target ptcls
security surveillance increasing need process image data efficiently effectively either source large data network whilst field programmable gate array seen key technology enabling design process viewed problematic terms time effort needed implementation verification work proposes different approach using optimized fpga based soft core processors allows user exploit task data level parallelism achieve quality dedicated fpga implementations whilst reducing design time paper also reports preliminary progress design flow program structure implementation histogram gradients algorithm also reported shows performance fps achieved design approach whilst avoiding long design time verification debugging steps associated conventional fpga implementations
present study examined group differences error related negativity ern based perfectionism emotional intelligence eiq ern erp component generated anterior cingulate cortex peaks making error response task amplitude ern making mistake reflects individual differences emotional traits performance concerns past researchers found participants higher perfectionistic doubts displayed larger ern amplitudes however researchers yet differentiated type perfectionism adaptive maladaptive relation ern additionally previous researchers found affective processes reflected ern yet examined whether differences ern could influenced eiq participants present study adults responded surveys completed computerized ern paradigm utilizing flanker task neural activity recorded using eeg paradigm designed elicit high error rate thereby allowing capture measurement ern component anova results indicated maladaptive perfectionists greatest negativity followed adaptive perfectionists followed nonperfectionists anova results indicated individuals high eiq lower ern individuals low eiq elsevier ltd rights reserved
quality data regarding direct diffuse solar irradiation crucial proper design simulation solar systems information however available entire brazilian territory however hourly measurements global irradiation seven hundred stations territory available several mathematical models developed past decades aiming deliver estimations solar irradiation components measurement global irradiation available order provide reliable estimates diffuse direct radiation brazil recently presented boland ridley laurent brl model adjusted particular features brazilian climate data developing adjusted brl models minute hourly bases model adjusted using global diffuse direct solar irradiation measurements nine stations maintained inpe frame sonda project methodology processing analyzing quality data sets procedures build adjusted brl model thoroughly described error indicators show adjusted brl model performs better similarly original one diffuse dni estimates calculated analyzed brazilian station instance original brl model diffuse fraction estimates meape errors ranging adjusted brl model gives errors regarding comparison minute hourly adjusted models concluded performed similarly indicating logistic behavior original brl model well suited make estimates sub hourly data sets based results proposed adjusted model used provide reliable estimates distribution direct diffuse irradiation therefore help properly design reduce risks associated solar energy systems elsevier ltd rights reserved
order get thorough understanding total digital silicon micro gyroscope novel system level model details sense circuit presented paper unlike traditional structures digital part digital gyroscope structure programmable delay units pdus instead dplls gives brief robust character whole system pdus coordinating fir filter could lead removal filters sigma delta dac feedback saves lot consumption two mash sigma delta adcs designed convert output charge voltage converters digital signals also bring better stability adcs achieve snr khz bandwidth stabilization closed drive mode also analyzed including noise caused quantization digital circuit affecting stabilization amplitude frequency driving signals end final result simulation gyroscope shows correctness accuracy whole model gyroscope
paper presents load resistance factors reliability based design main cables earth anchored suspension bridges strength limit state defined aashto lrfd bridge design specifications reliability analyses performed three suspension bridges korea main span lengths ranging reliability indices probable failure points mpfp random variables evaluated strength load stiffness parameters taken account random variables advanced first order second moment method employed evaluate reliability indices mpfp random variables elastic catenary cable element utilized discretize main cables load factors proposed based normalized mpfp load component considered strength limit state resistance factor yields reference target reliability index main cable found two alternative resistance factors give lower higher reliability indices reference value also proposed proposed load resistance factors lead uniform reliability level main cable regardless length main span suspension bridge
centers medicare medicaid services coverage includes posttherapy fdg pet scans per patient per tumor type additional follow fdg pet scans reimbursed discretion local medicare administrator deemed medically necessary study aimed investigate common clinical indications performing fourth additional followup fdg pet scans could affect management patients methods retrospective institutional review oncology patients men mean age including total fourth subsequent follow pet scans completion primary treatment twelve indications performing fourth subsequent follow pet scan determined impact indications patients management evaluated results primary tumors breast cancer patients scans non hodgkin lymphoma patients scans hodgkin disease patients scans colorectal cancer patients scans melanoma patients scans lung cancer patients scans indications categorized groups pet diagnosis tumor recurrence pet starting therapy tumor recurrence pet assess therapy response tumor recurrence follow pet completion treatment tumor recurrence overall fourth subsequent follow fdg pet scans resulted change management scans scans obtained medical necessities indications scans scans obtained without medical necessity indication conclusion fourth subsequent pet scans obtained completion primary treatment led change management scans acquired appropriate clinical reasons performing follow pet without appropriate medical reason low impact patients management avoided
novel strategies address vitamin deficiency developed high carotenoid maize biofortified transgenic maize line rich carotenoids generated genetic transformation south african white maize inbred devoid carotenoids engineered accumulate high levels beta carotene provitamin lutein zeaxanthin maize seeds contaminated fumonisins mycotoxins pose serious threat humans livestock three consecutive harvests fungal incidence fumonisin aflatoxin content maize seeds grown experimental field catalonia northeastern spain evaluated fungal infection similar high carotenoid maize isogenic line fusarium verticillioides prevalent fungus harvests neither aspergillus spp aflatoxin contamination found fumonisin levels lower high carotenoid isogenic line reduction statistically significant years study results suggest high carotenoid content reduces fumonisin levels maize grains
paper proposes new high level approach optimising field programmable gate array fpga designs fpga designs commonly implemented low level hardware description languages hdls lack abstractions necessary identifying opportunities significant performance improvements using computer vision case study show modelling computation dataflow abstractions enables substantial restructuring fpga designs lowering hdl level also improve cpu performance using cpu transformations runtime reduced using fpga transformations clock frequency increased mhz mhz results outperform commercial low level hdl optimisations showcasing dataflow program abstraction amenable computation model highly effective fpga optimisation
background modern information technology overwhelming amount data available different aspects societies research investigated feasibility using secondary data sources get overview determinants health health outcomes different population strata cape town large city south africa methods methodological approach secondary data analysis similar different disciplines biological anthropology public health environmental health mental health palliative care medical psychology sociology university freiburg public health university cape town teams collected information cape town internet searches published articles information extracted analyzed condensed jointly interpreted results data show typical picture population epidemiological demographic transition exposed often difficult social mental physical environmental conditions comparison low higher socioeconomic districts demonstrated former higher air pollution poorer water quality deficient sanitary conditions addition sub optimal mental health services palliative care conclusion although important information gaps identified data draw attention critical public health interventions required poor health districts motivate pro equity policies
although vast majority existing work empathy focuses exclusively socio emotional consequences empathizing others negative emotions mounting evidence supports view empathy others negative emotions empathy others positive emotions distinct capacities present work seeks marry burgeoning literature separability positive negative empathy influential literature approach avoidance motivation examining two distinct empathic capacities relate pro social motivations assist others approach positivity avoid negativity results two studies show whereas positive empathy associated focused motivation assist others approach positive outcomes predictive helping help framed means propelling others toward greater positivity negative empathy associated focused motivation assist others avoid negative outcomes associated helping help framed means assisting others avoid suffering addition contributing emerging literature separability positive negative empathy results also help extend influential approach avoidance distinction domain focused motivation elsevier ltd rights reserved
paper present generalized unified method finding multiwave solutions time fractional dimensional nizhnik novikov veselov equations fractional derivatives described modified riemann liouville sense fractional complex transform suggested convert fractional order differential equations modified riemann liouville derivatives integer order differential equations reduced equations solved symbolic computation multiauxiliary equations introduced method obtain multisoliton solutions also multiperiodic multielliptic solutions shown considered method effective convenient solving wide classes nonlinear partial differential equations fractional order
frequent water stress episodes affecting urban hubs caused shift urban water management towards integrated approaches motivated search alternative water resources large scale rainwater harvesting municipal scale overcome disadvantages climate dependence volume restrictions associated small scale collection facilities paper two tools based urban metabolism concept used determine water self sufficiency potential urban systems urban runoff simple water self sufficiency potential indicator socioeconomic water flow accounting scheme includes water losses tools applied densely populated coastal area exemplifies urban centres mediterranean approach useful regions restricted data availability water use facilitates information dissemination policy makers results indicate significant water self sufficiency potential area study even projections reduced precipitation area
video game violence focus much recent concern among politicians activists social scientists evolutionary psychology help explain origins fascination many individuals particularly males violent games interest violent video games viewed extension normal adaptive aggression instincts video games provide safe arena individuals express aggression manage mood without actually causing harm others evolutionary model violent game interest catalyst model presented contrasted traditional social learning models video game violence use argued harmful effects violent game exposure majority players negligible whereas violent games may provide useful platform positive development education visuospatial cognition social networking
purpose test ipad delivered multiple behavior tailored intervention healthy pregnancy step step pregnant women addresses smoking cessation stress management fruit vegetable consumption design randomized factorial repeated measures design employed randomization individual level stratified behavior risk women completed three sessions pregnancy two postpartum postdelivery months setting women recruited six locations federally funded health centers across three states subjects participants english spanish speaking women weeks gestation intervention treatment group received three interactive sessions focused two priority health behavior risks sessions offered individually tailored stage matched change strategies based transtheoretical model behavior change usual care group received march dimes brochures measures primary outcome number behavior risks stage change continuous measures behaviors also assessed analysis data analyzed across time points using generalized estimating equations examining repeated measures effects results women treatment group reported significantly fewer risks usual care month odds ratio months postpartum conclusion healthy pregnancy evidence based personalized program assists pregnant women reducing behavior risks sustaining healthy lifestyle behaviors
different cooling structures cylinder head block corresponding thermal status thermal dissipation frictional power dissipation investigated study conventional engine cooling configuration coolant flow travels block head leading coolant temperature head higher block furthermore cooling problem block occur cooling system designed cooling requirements cylinder head without considering cooling load block paper developed single cylinder model analyse influence coolant flow direction split structure cooling head block analysis indicated top bottom flow cooling structure effectively reduce cylinder head thermal load slightly increase temperature cylinder liner combined split top bottom cooling structure proven optimal solution advantages lower thermal frictional power dissipation compared conventional cooling structure elsevier ltd rights reserved
metastasis accounts high mortality rate associated colorectal cancer crc metastasis regulators fully understood identify novel gene involved tumor metastasis used oligonucleotide microarrays transcriptome distance analyses machine learning algorithms determine links primary metastatic colorectal cancers aminopeptidase apa also known enpep selected focus relationship colorectal cancer requires clarification higher apa mrna levels observed patients advanced stages cancer suggesting correlation enpep degree malignancy data also indicate apa overexpression crc cells induced cell migration invasion anchorage independent capability mesenchyme like characteristics emt markers also observed twist induction apa overexpressing cells twist regulation cells knocked apa apa silencing impaired apa activity found reduce migratory capacity cancer anchorage stemness properties drug resistance vitro vivo therefore suggest apa enzymatic activity affects tumor initiation cancer malignancy twist dependent manner results qpcr immunohistochemical staining specimens taken crc patients indicate significant correlation apa twist according data survexpress analyses twist apa mrna expression profiles high apa twist expression positively correlated poor crc prognosis apa may act prognostic factor therapeutic target crc metastasis recurrence
water exposure skin hands previously studied adults aim study investigate self reported water exposure adolescents bamse cohort stockholm sweden questionnaire including question daily water exposure hands answered adolescents age years exposure times day reported times day boys somewhat higher exposure girls multivariate analysis adolescents dry skin reported higher exposure adjusted odds ratio oradj statistically significant exposure differences found relation hand eczema atopic dermatitis reported exposure may considered baseline exposure period life limited occupational domestic duties
governing procedure coupled monte carlo codes relies discretization simulation time time steps typically transport solution discrete points generate reaction rates codes assumed constant within time step assumption trigger numerical instabilities result loss accuracy turn would require reducing time steps size paper focuses reducing time discretization error without requiring additional transport solutions hence major computational overhead sub step method presented accounts reaction rate variation due variation nuclide densities thermal hydraulic conditions achieved performing additional depletion calculations within analyzed time step method implemented bgcore code subsequently used analyze series test cases results indicate computational speedup factor may achieved existing coupling schemes elsevier ltd rights reserved
article aims first argue fandom matters politics second offer theorisation call politicised fandom article proceeds three stages part offers brief mapping existing scholarship within interdisciplinary sub field fan studies alights definition fandom offered cornel sandvoss mapping different understandings fandom politics relation argue emphasis agency capacity fan communities intervene politically part provides initial theorisation politicised fandom highlighting four key elements productivity consumption community affect contestation part offers snapshots politicised fandom manifest empirically via analysis three similar yet different instances politicised fandom left politics russell brand milifandom corbyn mania
background antipsychotic medications widely used treat behavioral symptoms dementia however studies shown antipsychotic use patients dementia associated risk side effects aims aim study examine antipsychotic prescribing patterns beneficiaries dementia enrolled medicare advantage program identify opportunities improve prescribing practices methods study includes medicare advantage beneficiaries years age older dementia examined number participants prescribed antipsychotic medication descriptive analysis performed logistic regression models used describe correlates antipsychotic exposure results individuals medicare advantage population dementia diagnosis received antipsychotic medication correlates receiving antipsychotic medication included older age dual eligibility medicare medicaid morbid diagnosis depressive disorder substance use disorder female associated decreased antipsychotic medication use regional variations also noted conclusions care management programs medicare advantage opportunities address behavioral health needs older adults dementia limit inappropriate use antipsychotic medications
basic building blocks performing complex signal processing sinh domain introduced article attractive offered benefits capabilities achieving resistorless realisations electronic adjustment frequency characteristics independent tuning centre frequency bandwidth operating low voltage environment addition inherent class operation sinh domain filters allows handling signals greater bias current leading power saving aforementioned benefits evaluated simulation results using analog design environment cadence software
past years reversible watermarking techniques relational databases proposed provide protection ownership rights data tempering data integrity mainly techniques ensure original data recovery watermarked data whereas irreversible watermarking schemes protect ownership rights characteristic reversible watermarking emerged candidate solution protection ownership rights data intolerable modifications medical data genetic data credit card bank account data main objective paper make extensive survey state art reversible watermarking techniques relational databases reflect recent research progress point key issues future research order analyze techniques classification performed basis extent modifications introduced watermarking scheme underlying data robustness embedded watermark malicious attacks copyright john wiley sons ltd
gradient statistic based diagnostic measure developed context generalized linear mixed models performance assessed real examples simulation studies terms ability detecting influential data structures concordance used influence measures
vast number problem solving frameworks established realms management business mathematics healthcare aerospace law etcetera towards facilitating effective decision making normative form particular learnt problem solving frameworks originated mainly practical exercises practitioners improvement revision earlier frameworks bottom approach establishment problem solving frameworks paper continues promoting establishment problem solving framework following top approach synthesizing deductive inference second inference process pragmatism scientific method synthesis resulted identification decision sub processes pragmatism deductive inference namely analysis demonstration paper posits two decision processes aligned key strategies decision processes renowned problem solving frameworks practice management business mathematics healthcare law hence decision processes deductive inference particular pragmatism philosophical method general alternative decision making processes problem solving frameworks following top approach
purpose benign perivaginal masses pvm relatively rare aim study create higher awareness entities point reliable diagnostics accurate treatment methods medical records department obstetrics gynecology tuebingen searched number type urogynecological surgery general surgery took place particularly owing benign pvm period years diagnostics treatment histology postoperative management summarized analyzed vaginal endometriosis manifestations considered results total number women underwent urogynecological surgery particularly benign pvm benign pvm patient cohort composed follows urethral diverticula squamous epithelial inclusion cysts periurethral cysts gartner duct cysts llerian cysts pseudocysts abscesses epidermal inclusion cysts angiofibromas angiomyofibroblastomas leiomyomas solitary fibrous tumor masses due alloplastic materials pvm occurred singly multiply asymptomatic accompanied symptoms case history clinical examination pelvic floor sonography urethrocystoscopy mri essential tools diagnostics pvm simulated cystoceles recto enteroceles cause overactive bladder dyspareunia pain concomitants women stress urinary incontinence pvm excised cases one case infected regressed completely conservative antibiotic therapy conclusions awareness benign pvm helpful diagnostics management secondary pathology intradiverticular stones malignancy considered
objectives eating disorders important health issues body image disturbances disorders limited western countries females current study aimed investigate prevalence eating disorders among iranian male adolescents associated factors materials methods cross sectional survey conducted male high school students study assessed effects demographic characteristics social pressures family friends self esteem body satisfaction media eating disorders results presented terms odds ratio confidence interval values less considered statistically significant results male adolescents eating disorders significant differences two groups without eating disorders terms social pressure body dissatisfaction body mass index bmi body dissatisfaction bmi identified predictive factors eating disorders conclusions results indicated need attention eating disorders predictive factors iranian adolescents example asian cultures
research risk factors adults tendencies limited still unclear whether association tendencies non clinical individuals exists goal present study test associations tendencies self perception personality traits depressive symptoms among non clinical adult population investigated italian sample adults administered set self report questionnaires assess obsessive compulsive tendencies depression self perception personality traits hopelessness confirmatory factor analyses cfa performed final model found personality obsessive compulsive factor suicidal ideation significantly correlated personality correlated negatively obsessive compulsive factor suicidal ideation obsessive compulsive factor suicidal ideation resulted strongly positively associated results highlight importance assessing tendencies negative self perception understanding role interplay allow development implementation advanced prevention treatment policies
objective paper investigated beliefs around breastfeeding norm postpartum abstinence influence sexual behavior based larger project explored gender relations affect reproductive processes reproductive health tarok women north central nigeria methods research conducted four tarok communities using qualitative instruments namely depth interviews idis focus group discussion fgd guides participants female male community members years sixteen idis four per community conducted women religious traditional leaders well senior health providers twenty four fgd sessions six per community held different groups community data descriptively analyzed results findings demonstrated customary double standards sexual matters significance influence certain unfounded traditional beliefs around breastfeeding sexual behavior choices well changes characterize sexual relationships among modern tarok couples brought christianity western education modernity conclusion traditional breastfeeding norms beliefs seek overly control women sexuality giving precedence interest child father study calls change attitude meet demands current reality order strengthen marital unions guarantee healthy families elsevier rights reserved
strong designated verifier signature message recovery sdvswmr scheme designated receiver capability recover validate message signature pair using bilinear pairing islam biswas presented sdvswmr scheme call isbi sdvswmr non delegatability better performance schemes terms communication computation cost however study address isbi sdvswm scheme satisfy security property non delegatability claimed present two types delegatability attack scheme also propose new pairing free sdvswmr scheme possesses following security requirements non delegatability unforgeability non transferability privacy signer identity prsi compared scheme existing related schemes scheme obtains better performance computational cost lower isbi sdvswm scheme schemes communication cost bits lower isbi sdvswm scheme schemes copyright john wiley sons ltd
serious games generally considered good alternative improve motivation learn game meaningful mechanics elements involve players keep attention person motivation play games leads different types players consequently need different types elements keep engaged understanding player behaviour important issue improve support game designer serious game focus mainly educational value also important incorporate fun elements game developing serious game aimed help development basic computer programming skills challenge create game provides effective self learning support keeping student engaged game missions paper deals game features evaluation game missions covering basic concepts computer programming sequence actions variable manipulation conditionals research concerned evaluating game enjoyment conducted two experiments groups students completely distinct knowledge areas first applied game portuguese education sciences class included essentially female students next performed play test brazilian first semester software engineering undergraduate class composed essentially male students believed would identify larger set needs diversified types players tried game consequently game satisfies needs would reduce possibility failure game egameflow instrument used measure enjoyment findings show game entertains players even programming tasks hard however improvements necessary foster self learning finally paper presents future work aims include new challenges missions game improve enjoyment
study proposes new design method active mass damper amd based auto regressive exogenous models building structure proposed method uses results system identification field active structural control uncontrolled structure identified auto regressive exogenous models via measurements earthquake excitation forced vibration models linked equation motion amd introduce state equation output equation amd structure interaction system discrete time space equations apply modern control theories amd design numerical applications degree freedom building structure linear quadratic regulator control used understand fundamental characteristics proposed design procedure feedback control law requires amd acceleration velocity stroke structure acceleration ground acceleration vibration measurements numerical examples confirm high applicability control effectiveness proposed method one remarkable advantage proposed method equation motion structure becomes unnecessary designing controllers copyright john wiley sons ltd
parents psychopathology alcohol use disorder aud confers risk suicide attempt may children likely develop psychopathology attempt suicide suggesting risk may transmitted parents children examined phenomenon transition childhood adolescence risk increases dramatically cohort children examined average age range years enrollment time childhood approximately years later prior reaching age time adolescence one biological parents oversampled aud also interviewed structural equation models sem examined father child mother child either parent child associations primary outcome follow among offspring assessed time hypothesized parental antisocial personality disorder predicted conduct disorder symptoms offspring childhood adolescence parent child model father child model maternal aud predicted conduct disorder symptoms childhood mother child model however find evidence support transmission depression parents offspring either childhood adolescence parent psychopathology show statistically significant associations adolescence conclusion conducted rare study parent child transmission risk used prospective research design included diagnostic interviews parents offspring examined transition childhood adolescence first study children parents aud results provided mixed support hypothesized parent child associations
background individuals family history alcoholism enhanced risk developing alcohol substance use disorders relative family history alcoholics subjects greater interference scores stroop color word task suggesting impairments may component cognitive phenotype risk individuals methods study examined whole brain activations young adults performing counting stroop task variant stroop task adapted neuroimaging studies results across subjects incongruent versus congruent comparisons showed activations regions including parietal lobe areas frontal eye fields premotor areas anterior cingulate cortex dorsolateral prefrontal cortex bilateral insula indicating typical regions activation involved conflict resolution tasks compared participants participants greater activations left superior parietal lobule precuneus inferior parietal lobule middle temporal gyrus indicating predominance greater left hemisphere activity among temporoparietal regions regions showing greater activations group compared group conclusions results consistent less efficient cognitive functioning potentially due poorer communication long pathways connecting temporoparietal regions prefrontal brain regions participate distributed network involved cognitive processing working memory necessary conflict resolution
background chlamydia trachomatis trichomonas vaginalis two prevalent sexually transmitted infections known increase hiv risk women could potentially diminish preexposure prophylaxis efficacy particularly topical interventions rely local protection investigated macaques whether coinfection chlamydia trachomatis trichomonas vaginalis reduces protection vaginal tenofovir tfv gel methods vaginal tfv gel dosing previously shown provide protection applied either min days simian hiv shiv challenge assessed pigtailed macaques coinfected chlamydia trachomatis trichomonas vaginalis challenged twice weekly shivp weeks two menstrual cycles three groups six macaques received either placebo tfv gel min days shiv challenge additionally assessed tfv tfv diphosphate concentrations plasma vaginal tissues chlamydia trachomatis trichomonas vaginalis coinfected uninfected macaques results chlamydia trachomatis trichomonas vaginalis coinfections maintained shiv challenge period macaques received placebo gel shiv infected median seven challenges one menstrual cycle contrast infections observed macaques treated tfv gel min shiv challenge efficacy reduced tfv gel applied days shiv challenge plasma tfv tfv diphosphate concentrations tissues vaginal lymphocytes significantly higher chlamydia trachomatis trichomonas vaginalis coinfected compared chlamydia trachomatis trichomonas vaginalis uninfected macaques conclusion findings model suggest chlamydia trachomatis trichomonas vaginalis coinfection may little impact efficacy highly effective topical tfv modalities highlight significant modulation tfv pharmacokinetics copyright wolters kluwer health inc rights reserved
concept pulse position modulation coding based group delay engineered microwave section dispersive delay structures ddss experimentally demonstrated novel chipless radio frequency identification rfid system tags consist various ddss whose group delay responses engineered provide different pulse position modulation ppm codes bit system presented rfid reader various different dds based tags proposed concept offers system simplicity frequency scalability ary coding capability large coding diversity
investigate semisupervised learning pool based active learning classifier domains label scarce unknown categories defined categories initially labeled examples scenario manifests category rare expensive label several learning issues unknown categories priori unknown subset possibly many measured features needed discriminate unknown common classes label scarcity suggests overtraining concern classifier exploits inductive bias unknown class consists subset unlabeled pool samples atypical relative common classes respect certain key albeit priori unknown features feature interactions accordingly treat negative log values raw features nonnegatively weighted derived feature inputs class posterior zero weights identifying irrelevant features hierarchical class posterior model accommodates multiple common classes multiple classes unknown classes learning propose novel semisupervised objective customized unknown category scenarios several works minimize class decision uncertainty unlabeled samples instead preserve uncertainty maximum entropy maxent avoid overtraining experiments variety uci machine learning domains show use value features coupled weight constraints leads sparse solutions gives significant improvement use raw features unlabeled samples helpful used preserve decision uncertainty maxent rather minimize especially early stages system leveraging novel sample selection scheme discovers unknown classes discriminates classes common ones sparing use oracle labeling
psychological research relationship spirituality religion mental health grown considerably past several decades constitutes sizable body scholarship among dimensions positive beliefs god significantly related better mental health outcomes conversely negative beliefs god generally associated distress however prior research topic relied heavily upon self report likert type scales vulnerable self report biases measure explicit cognitive processes study developed validated implicit social cognition task positive negative god association task png gnat use psychological research spirituality religion preliminary evidence large sample suggests png gnat demonstrates internal consistency test retest split half reliability concurrent evidence validity results suggest png gnat scores represent different underlying dimensions explicit self report measures incrementally predict mental health beyond self report assessment png gnat appears effective tool measuring implicit positive negative beliefs god
background past decades bariatric surgery especially roux gastric bypass rygb become widely considered effective treatment morbid obesity cases results enhanced glucose management patients obesity type diabetes observed significant weight loss however accounts effect remains controversial gain insight benefits rygb investigated changes beta cell mass obese rats following rygb material methods rygb sham operation performed obese rats fed high fat diet hfd weeks hfd continued weeks groups additional normal chow diet ncd obese groups used controls results present study rygb induced improved glycemic control enhanced beta cell function reflected better glucose tolerance rapidly increased secretion insulin peptide glucose administration consistently rats rygb group displayed increased beta cell mass islet numbers attributed part increased glucagon like peptide levels following rygb conclusions data indicate rygb improve beta cell function via increasing beta cell mass plays key role improved glycemic control rygb
propose build programming development environment advance software development important class embedded systems focus array processing elements handling data level words automatic data flow synchronization local connections nearby elements model especially suitable digital signal processing dsp applications shown case studies systems capable delivering unprecedented performance goal provide high level programming tools simplify lowlevel embedded programming permitting flexibility design model computation foundation consists models
common anaesthetic analgesic agents used pregnancy mice observed cause fetal growth restriction investigated impact therapeutic doses three anaesthetics ketamine xylazine isoflurane tribromoethanol two analgesics buprenorphine meloxicam fetal placental growth pregnant mice treated one agents fertilization attachment beginning organogenesis end organogenesis logarithmic growth phase placed untreated control group term fetal placental growth evaluated morphological analyses performed skeletal measurements conducted fetal growth reduced significantly ketamine xylazine treatment isoflurane administered tribromoethanol administered two day treatment buprenorphine beginning meloxicam also significantly reduced fetal growth neither placental growth litter size significantly affected agents occurrence microphthalmia nearly eight fold higher response buprenorphine administration compared controls length humerus reduced gestation times response agents correlated fetal weight ketamine xylazine tribromoethanol meloxicam data reveal patterns acceptable detrimental anaesthetic analgesic use fetal development refined capability provide recommendations use agents pregnancy mouse
purpose leadership identified key variable functioning teams one main reasons success failure team based work systems pediatricians often function team leaders resuscitation critically ill child however pediatric residents often report little opportunity perform role team leader residency order gain insight leadership skills behaviors classified leadership styles pediatric residents simulated emergencies methods conducted prospective quantitative study investigate leadership styles used pediatric residents simulated emergencies clinical deterioration child pediatric ward using videotaped scenarios simulated critical events among residents able classify verbal nonverbal communication different leadership styles according situational leadership theory results coaching style mean frequently applied residents followed directing style mean pattern conforms task role related requirements scenarios also conforms concept situational leadership find significant differences leadership style according postgraduate year scenario content conclusion model used pilot study helps gain better understanding development effective leadership behavior supports applicability situational leadership theory training leadership skills residency
practical report analyzes programming class using micro robot smallest soccer robot robocup world competition class examined effect using actual equipment employed programming questionnaire results class revealed teaching materials evoked heightened programming interest among students moreover problems related programming instruction using better understood therefore strategy improving related problems discussed wiley periodicals inc comput appl eng educ view article online doi
investigation surface roughness thin films important issue manufacturing engineering performance coated film significantly affected surface roughness thin films fast flexible optical measurement system measure surface roughness hard coatings deposited cathodic arc evaporation developed work objective work examine repeatability reproducibility optical measurement system percentage equipment variation appraiser variation thin film optical measurement system developed acceptable according measurement systems analysis technique elsevier gmbh rights reserved
reasonable determination cable tensions main cable configuration key issue designing suspension bridges based interacting matrix theory optimisation method cable force suspension bridges deduced linear structure interacting matrix linear non linear structure suspension bridge large deformation effect strong superposition principle applicable interacting matrix theory applied especially linear structure interacting matrix suspension bridge could gotten taking account dead load stiffness based interacting matrix cable forces gotten iterations non linear fem procedure consists two successive steps non linear analysis first step interacting matrix formation procedure interacting matrix suspension bridge could gotten taking account dead load stiffness successive non linear analyses performed trial nodal coordinates unstrained lengths cable elements resulted target optimisation procedure designated targets achieved concerning structure stiffness reasonable shape suspension bridge gotten addition case study suspension bridge carried show capability proposed method showed method advantages mechanical significance concise algorithm high accuracy worth popularising design practice
energy supply systems usually considered individual sub systems separate energy vectors however use combined heat power chp units heat pumps electric boilers creates linkages electricity heat networks two combined analysis methods developed investigate performance electricity heat networks integrated whole two methods decomposed integrated electrical hydraulic thermal calculation techniques forms power flow simple optimal dispatch methods based models electrical network hydraulic thermal circuits coupling components focusing chp units circulation pumps case study barry island electricity district heating networks conducted showing electrical heat demand self sufficient system interconnection external systems met using chp units comparison showed integrated method requires less iteration decomposed method authors published elsevier ltd open access article license http creativecommons org licenses
smart grid concept promises reliable efficient supply electricity recognizes growing importance information communication technologies icts incorporating ict existing electrical network transform smart intelligent grid vivid study components smart grid smart meter tod meter ict advanced metering infrastructure ami illustrated based visits different places like lavasa kalkhairewadi bhigwan pune district maharashtra state india application smart meters fault location focused paper efforts taken highlight issues traditional fault locating techniques transmission distribution network
males outperform females spatial tasks may partially due effects sex steroids spatial strategy preferences previous work rodents indicates low estradiol levels bias females toward striatum dependent response strategy whereas high estradiol levels bias toward hippocampus dependent place strategy tested whether testosterone influenced strategy preferences male rats subjects castrated assigned one three daily injection doses testosterone rat control group received daily injections drug vehicle three different maze protocols used determine rats strategy preferences low dose testosterone biased males toward motor response strategy maze task water maze task platform could used intermittently visual cue low testosterone dose caused significant increase use cued response strategy relative control males results second experiment also indicated males receiving high dose testosterone biased toward place strategy third experiment indicated testosterone dose strong influence ability rats use nearby visual cue floating ball water maze experiment groups seemed use combination place cued response strategies overall results indicate effects testosterone spatial strategy preference dose dependent task dependent elsevier inc rights reserved
theories value development often identify adolescence period value formation cultural familial factors sources value priorities however recent research suggests value priorities observed early middle childhood several studies including one preadolescents suggested genetic contribution individual differences values current study pairs monozygotic dizygotic seven year old israeli twins completed picture based value survey children pbvs replicated basic patterns relations value priorities variables socializationgender religiosity socioeconomic statusthat found studies adults important values self transcendence self enhancement conservation found significantly affected genetic factors percent percent percent respectively well non shared environment percent percent percent respectively openness change values contrast found unaffected genetic factors age influenced shared percent non shared percent environment findings support recent view values formed earlier ages assumed previously understanding genetic environmental factors involved value formation young ages
background emotions potent modulators motivators behaviour individual displays different situations live act protection factor vulnerability adapted maladaptive behaviour study focuses anxiety adolescence objectives objective longitudinal study analyse psychological processes emotions facilitate symptoms anxiety protect adolescent symptoms material methods adolescents boys girls participated three wave longitudinal study valencia spain first wave adolescents either third year secondary school boys girls fourth year secondary school boys girls mean age range years study monitored participating adolescents three years results results indicate differential profile evaluated emotions according sex girls ones experiment anxiety empathy boys show emotional instability aggression conclusions concluded best predictors anxiety anger state aggressive behaviour empathic concern together lack coping mechanisms focused problem solving perception stress threat
present work case carmenes del mar resort granada spain shown considered one extreme examples mediterranean coast severe pathologies associated urban development coastal landslides resort dwellings partially built deep seated landslide affects soft formation composed dark graphite schists november city council officially declared state emergency resort dwellings already evacuated used two remote sensing techniques monitor landslide aim identifying measuring wide range displacements rates year year psinsar exploiting envisat sar images acquired may december photogrammetry considering output two unmanned aerial vehicle uav flights made june january outdated photos conventional flight relationship geology site data deformation measurements building displacements rainfall damage observed temporal occurrence allows better understanding landslide kinematics spatial temporal evolution instability results indicate building displacements years clear lithological control spatial distribution damage close relationship damaging events water recharge episodes rainy events leaks swimming pools water supply network work emphasises need incorporate geohazards urban planning including policies predict prepare prevent type phenomenon
dense motion field estimation key computer vision problem many solutions proposed compute small large displacements narrow wide baseline stereo disparity non rigid surface registration unified methodology still lacking authors introduce general framework robustly combines direct feature based matching feature based cost built around novel robust distance function handles keypoints weak features segments allows use putative feature matches guide dense motion estimation local minima authors framework uses robust direct data term implemented powerful second order regularisation external self occlusion reasoning framework achieves state art performance several cases standard optical flow benchmarks wide baseline stereo non rigid surface registration framework modular design customises specific application needs
location allocation modeling important area research spatial optimization giscience large number analytical models location allocation analysis developed past years meet requirements different planning spatial analytic applications ranging location emergency response units ems warehouses transportation hubs despite great number many location allocation models intrinsically linked one another well known example theoretical link classic median problem coverage location problems recently lei church showed large number classic new location models posed special case problems new modeling construct called vector assignment ordered median problem vaomp lei church also reported extremely high computational complexity optimally solving best integer linear programming ilp formulation developed vaomp even medium sized problems certain cases article develop efficient unified solver location allocation analysis based vaomp model without using ilp solvers aim develop fast heuristic algorithm based tabu search meta heuristic message passing interface mpi suitable obtaining optimal near optimal solutions vaomp real time environment unified approach particularly interesting perspective giscience spatial decision support systems dss makes possible solve wide variety location models unified manner gis environment computational results show method often obtain seconds solutions better obtained using ilp based approach hours day
modification energy based approach called dissipating energy flow def method proposed uses data phasor measurement units pmus trace source poorly damped natural forced oscillations power systems original energy based approach chen assumes ability determine steady state values variables measured pmu transient process prevents reliable use original method actual pmu data pmu data processing proposed def method key step converting energy based method robust automated tool use actual pmu data effectiveness proposed def method demonstrated testing multiple simulated cases sustained oscillations including poorly damped natural forced oscillations actual events iso new england iso two events western electricity coordination council wecc systems study also demonstrates potential using def method estimate contribution generator damping specific oscillation mode elsevier ltd rights reserved
today commercially available word processors allow people write collaboratively cloud familiar asynchronous mode synchronous mode well opens new ways working together examined data traces collaborative writing behavior student teams use google docs discover writing together found student teams write synchronously asynchronously take fluid roles writing editing documents show variety styles collaborative writing including writing scratch beginning outline pasting related example template organize writing three also found document serves place share number things included final document including links references related materials assignment requirements instructor informal discussions coordinate collaboration structure document computed number measures depict group collaboration behavior asked external graders score documents quality found documents included balanced participation exhibited leadership judged higher quality longer suggested system design implications behavioral guidelines support people writing together better concluded paper future research directions
biomass energy conversion important action reach sustainability particularly small scale among different biomasses however vegetable oils fire directly compression ignited internal combustion engine minimal pre treatment fuel adaptation engine energy production waste cooking oils even interesting allows energy production disposing residue data available literature rarely referring commercially available engines therefore additional information required overall performance emissions maintenance requirements paper presents results tests carried fuelling commercially available direct injection diesel engine different fuels diesel used benchmark biodiesel linseed oil rbdpo refined bleached deodorized palm oil corn oil soy oil peanuts oil sunflower oil palm oil waste frying sunflower oil waste frying palm oil tests performed three different loads measuring fuel consumption electricity production exhaust gases temperature composition fuel injectors checked following test evaluate fouling caused different fuels results show increasing load fuel consumption shows general decreasing trend emissions decrease nox increase fuels show higher consumption diesel due lower calorific value biodiesel emissions decrease power increasing lower slope diesel therefore lower lowest power higher highest power biodiesel emissions always higher diesel vegetable oil emissions higher lower diesel ones depending power fuel emissions often higher diesel ones specific fuel consumption emissions waste frying vegetable oil generally comparable pure oils elsevier ltd rights reserved
sympathetic nervous system identified major contributor pathophysiology chronic heart failure chf diseases hypertension diabetes experimental animal models patients kidneys dense afferent sensory innervation positioning origin multimodal input central nervous system afferent renal nerve arn signals centrally integrated activation results general increase sympathetic tone directed toward kidneys well peripheral organs innervated sympathetic nerves central nervous system stimulation arn increases neuronal discharge frequency neuronal activity paraventricular nucleus pvn hypothalamus activity neurons pvn attenuated iontophoretic application glutamate receptor blocker enhanced afferent renal input pvn may critically involved dictating sympathoexcitation chf furthermore renal denervation abrogates enhanced neuronal activity within pvn rats chf thereby possibly contributing reduction sympathetic tone renal denervation also restores decreased endogenous levels neuronal nitric oxide synthase nnos pvn rats chf overall data demonstrate sensory information originating kidney excites pre autonomic sympathetic neurons within pvn renal pvn afferent pathway may contribute elevated sympathetic nerve activity hyper sympathetic disease conditions chf hypertension elsevier rights reserved
telehealth technologies promise increase access care particularly underserved communities however little known private payer reimbursements vary telehealth non telehealth services use largest private claims database united states provided health care cost institute identify telehealth claims compare average reimbursements non telehealth claims find average reimbursements telehealth services significantly lower non telehealth seven ten common services example telehealth reimbursements office visits evaluation management established patients low complexity lower corresponding non telehealth service reimbursements clinical diagnosis code also tended lower telehealth non telehealth claims widespread adoption telehealth may hampered lower reimbursements telehealth services relative face face services may result lower incentives providers invest telehealth technologies result significant cost savings practice even telehealth improves patient outcomes
objective review current neuromodulation treatments available migraine therapy acute preventive setting methods published literature reviewed studies reporting effects different neuromodulation strategies migraine without aura use non invasive single pulse transcranial magnetic stimulation non invasive vagal nerve stimulation supraorbital nerve stimulation transcranial direct current stimulation well invasive methods occipital nerve stimulation sphenopalatine ganglion stimulation assessed results available evidence shows non invasive techniques represent promising treatment strategies whereas invasive approach used patients refractory preventives including non invasive methods conclusions neuromodulation emerging exciting approach migraine therapy especially context failure commonly used medicines patients tolerate common side effects studies appropriate blinding strategies needed confirm results new treatment opportunities
back pain upper extremities injuries due overexertion account twenty percent leave days work explains vast amount initiatives date carried aiming reducing occurrence type injuries however although type lesions among studied occupational medicine automatic detection prevention technologies pervasively available date workplaces deficiency ascribable absence flexible cost effective tectaphnology may play role work aims filling gap contribution paper design implementation movement posture computervision based system performing sensor detect overexertion movements helping avoid common injuries cause tasks carried use simple webcam thus requiring expensive specialized microsoft kinect hardware device proposed technology hence easily affordable type company production plant throughout world easy adaptable recognize detect wide set movements postures validity approach demonstrated realistic settings wide set experiments
article presents signature free distributed algorithm builds atomic read write shared memory top fully connected peer peer process asynchronous message passing system processes may commit byzantine failures conceptual point view algorithm designed close possible algorithm proposed attiya bar noy dolev acm builds atomic register process asynchronous message passing system processes may crash proposed algorithm particularly simple use cryptography cope byzantine processes optimal resilience point view read operation requires messages write operation requires messages
mitogen activated protein kinase phosphatase mkp expression induced inflammatory factors serves endogenous mapk suppressor limit inflammatory response glucocorticoids effective anti inflammatory drugs used treatment many inflammatory diseases asthma copd investigated role mkp inhibition cytokine production dexamethasone human bronchial epithelial cells found dexamethasone increased mkp expression inhibited mapk phosphorylation suppressed tnf mip alpha production cells interestingly suppression mapk phosphorylation inhibition tnf expression dexamethasone attenuated cells mkp expression silenced sirna conclusion data suggest dexamethasone increases mkp expression results suppression mapk signaling leading inhibition cytokine production human bronchial epithelial cells results point role mkp important factor therapeutic effects glucocorticoids treatment inflammatory lung diseases
research focused control vehicle suspension means magnetic resistant force coming generating process suspension system vibrates kinetic energy transformed electrical energy designed transmission mechanism converts translational motion rotational motion combined claw pole generator resistant force generating current could occur vibrations theory electrical generator known exciting current generator could determine resistant force play important role control system hence paper new adaptive controller properly designing exciting current proposed actively control suspension system experiments performed demonstrate feasibility devised control scheme
merging computational thinking embodiment centered curriculum venvi virtual environment interactions seeks expand professional academic possibilities students opening pathways synthesize knowledge across digital media computer science arts paper presents findings case study research intervention grade students arts magnet school small urban municipality southeastern united states research iteration part larger ongoing design based research project pioneering design development testing virtual environment associated curriculum blending creative movement computer programming upper elementary middle school students conducting quantitative qualitative analysis researchers found students computational knowledge improved engagements constellation multimodal literacy practices steinkuehler process choreographing programming complimentary virtual character movements based grade biology standard cells
fuzzy logic used flexible database querying years paper examines issues flexible querying seem potential research development theoretical practical points view precisely defining appropriate fuzzy sets queries calculating matching degrees commutative non commutative query conditions preferences merging constraints wishes empty overabundant answers views practical realizations discussed paper suggestions solve integrate one compact solution also outlined paper
political redistricting well known problem political science geographic information science formulated combinatorial optimization problem objectives constraints defined meet legal requirements formulated optimization problem hard develop scalable evolutionary computational approach utilizing massively parallel high performance computing political redistricting optimization analysis fine levels granularity computational approach based strong substantive knowledge deep adherence supreme court mandates since spatial configuration plays critical role effectiveness numerical efficiency redistricting algorithms designed spatial evolutionary algorithm operators incorporate spatial characteristics effectively search solution space parallelization algorithm harnesses massive parallel computing power provided supercomputers via coupling search processes highly scalable message passing model maximizes overlapping computing communication runtime experimental results demonstrate desirable effectiveness scalability approach processors solving large redistricting problems enables substantive research relationship democratic ideals phenomena partisan gerrymandering elsevier ltd rights reserved
psychosis one debilitating non motor symptoms nms parkinson disease cognitive impairment considered risk factor emergence psychosis early detection relevant cognitive impairment may serve predictor development psychosis implications prevention early intervention however exact pattern cognitive impairment associated psychosis clear article aim critically review literature case control studies patients without psychosis order understand pattern cognitive impairment psychosis majority studies conducted till date focused executive visuospatial functions despite inconsistencies studies found significant impairment domains patients psychosis compared without psychosis studies assessing cognitive functions attention language memory patients also found worse performance psychosis although enough evidence suggest patients psychosis poor cognitive functioning unclear deficits generalized specific available evidence primarily form cross sectional studies assessing specific cognitive deficits adequate indicate clear demarcating pattern cognitive deficits differentiates patients without psychosis longitudinal studies extensive cognitive assessment warranted elsevier ltd rights reserved
background although accountable care organizations acos defined provision primary care services relationship intensity primary care population level utilization costs health care services examined early implementation medicare shared savings program mssp acos objective evaluate association primary care focus healthcare utilization spending first performance period medicare shared savings program mssp accountable care organizations acos methods retrospective cohort study divided mssp acos quartiles primary care focus based percentage ambulatory evaluation management services delivered pcp internist family physician geriatrician using multivariable regression evaluated rates utilization spending initial performance period adjusting percentage non white patients region number months enrolled mssp number beneficiary person years percentage dual eligible beneficiaries percentage beneficiaries age results proportion ambulatory evaluation management services delivered pcp ranged highest quartile acos greatest pcp focus acos highest quartile pcp focus higher adjusted rates utilization acute care hospital admissions per person years per person years emergency department visits per person years compared acos lowest quartile pcp focus acos highest quartile pcp focus achieved greater savings per beneficiary relative spending benchmarks benchmark benchmark conclusions primary care focus associated increased savings lower utilization healthcare initial implementation mssp acos
unmanned aerial vehicles uavs provide flexible low cost solution acquisition high resolution data potential high resolution uav imagery create update cadastral maps increasingly investigated existing procedures generally involve substantial fieldwork many manual processes arguably multiple parts uav based cadastral mapping workflows could automated specifically many cadastral boundaries coincide visible boundaries could extracted automatically using image analysis methods study investigates transferability gpb contour detection state art computer vision method remotely sensed uav images uav based cadastral mapping results show approach transferable uav data automated cadastral mapping object contours comprehensively detected completeness correctness rates detection quality optimal entire scene covered one orthoimage due global optimization gpb contour detection however balance high completeness correctness hard achieve combination area based segmentation object knowledge proposed localization quality exhibits usual dependency ground resolution approach potential accelerate process general boundary delineation creation updating cadastral maps
australia approximately people diagnosed hiv accessing treatment receiving treatment fail achieve viral suppression barriers limiting effective care warrant examination mixed methods systematic review accessed health social sector research databases november december identify studies explored perspective people living hiv australia articles included analysis described experiences knowledge attitudes beliefs relation treatment uptake adherence published january december quality appraisal utilised mixed methods appraisal tool version seventy two studies met inclusion criteria reviewed interplay lack knowledge fear stigma physical emotional social issues found negatively impact treatment uptake adherence strategies targeting individual wider community needed address barriers
objective growing evidence suggests deleterious consequences exposure childhood maltreatment might endure exposed individual lifespan also might transmitted across generations time windows mechanisms targets intergenerational transmission poorly understood prevailing paradigm posits mother child transmission effects maternal likely occurs child birth authors seek extend paradigm advance transdisciplinary framework integrates concepts biological embedding life experiences fetal origins health disease risk method authors posit period embryonic fetal life represents particularly sensitive time intergenerational transmission developing brain represents target particular interest stress sensitive maternal placental fetal biological endocrine immune pathways represent leading candidate mechanisms interest results plausibility model supported theoretical considerations empirical findings humans animals authors synthesize several research areas identify important knowledge gaps might warrant study conclusion scientific public health relevance effort relates achieving better understanding intergenerational transmission implications early identification risk prevention intervention
hiv susceptibility linked hormonal contraception studied mixed results reports recent findings prompted world health organisation encourage women use concurrently use condoms order prevent hiv infection light possible increased hiv risk infection associated hormone based contraceptives two sex hiv model classifying women three risk groups consisting individuals use condoms natural methods hormone based contraceptives formulated analysed assess possible effects various birth control strategies transmission dynamics disease model results showed women use could key drivers epidemic increased infectivity may critical driving epidemic women use hormone based contraceptives potentially act core group men get infected turn transmit disease population groups fitted model hiv prevalence data zimbabwe reported unaids zimbabwe ministry health child care used model fit project hiv prevalence predictions using hiv data zimbabwe suggest hypothesised increase susceptibility infectivity two three fourfold would result increase baseline hiv prevalence projection respectively thus suggesting possible increased disease burden even countries reporting plausible hiv prevalence declines although possible causal relationship hiv susceptibility use remains subject continuing scientific probe inclusion part birth control strategy shown study possibly increase hiv transmission proven use may potentially explain inordinate spread hiv within sub saharan africa region therefore compel urgent assessment view reorienting birth control methods use settings generalised epidemics
paper proposes explicit definition green software requirements tool support evaluation proposed evaluation tool describes green efficiency considering energy consumption main aspect studied development stage approach consists building multiple regression model using supervised learning algorithm order reproduce energy consumption pattern devices different workload circumstances energy consumption model deployed estimate impact software applications based resource usage work validated desktop mobile devices experiments show effectiveness proposed energy profiling tool provided relevant information energy consumption software applications
background postmenopausal women decreasing estrogen levels marker ovarian dysfunction hypoestrogenic state known increasing risk osteoporosis objective determine correlation estradiol serum levels classification osteoporosis risk osta osteoporosis self assessment tools asian menopausal women methods study case series study examined estradiol serum menopausal women elisa assess osteoporosis risk using osteoporosis risk classification osta total samples collected adam malik pirngadi rsu networking medan research conducted may december data statistically analyzed presented spearman test results study found mean levels estradiol menopausal women osta osteoporosis risk score significant positive correlation estradiol risk osteoporosis osta correlation coefficient conclusion strong positive correlation serum levels estradiol osta osteoporosis risk assessment menopausal women
present numerical simulations directional coupler based three dimensional waveguides made nematic liquid crystal acting waveguide core infiltrated polydimethysiloxane channels modeling based combination minimization oseen frank energy liquid crystal molecules beam propagation algorithm design coupler waveguides optimized minimize coupling lengths maximise efficiencies components made low cost flexible plastic substrates also integrated optofluidic devices biomedical applications
though many computational models proposed saliency detection take object boundary information account paper presents hierarchical saliency detection model incorporating probabilistic object boundaries based observation salient objects generally surrounded explicit boundaries show contrast surroundings perform adaptive thresholding operation ultrametric contour map leads hierarchical image segmentations compute saliency map layer based proposed robust center bias border bias color dissimilarity spatial coherence measures linear weighted combination multi layer saliency maps bayesian enhancement procedure final saliency map obtained extensive experimental results three challenging benchmark datasets demonstrate proposed model outperforms eight state art saliency detection models
patriotism threat shown predict immigration attitudes suggest patriotism influential producing threat threat drives anti immigration attitudes relationship different whites latinos participants completed patriotism scale blind constructive patriotism measures threat scale realistic symbolic threat anti immigration attitude scale latinos showed lower blind patriotism realistic threat symbolic threat anti immigration attitudes compared whites differences constructive patriotism threat partially mediated relationship blind patriotism anti immigration attitudes whites fully mediated relationship latinos threat partially mediated relationship cultural patriotism anti immigration attitude whites latinos implications public policy education concerning immigrant attitudes discussed
following widespread implementation large projects huge budgets need finish time well importance final product quality safety standards large scale projects necessity field management felt ever study conducted investigate evaluate compliance various well known standards project management civil projects achieve efforts made using statistical analysis multi criteria decision analysis method topsis expert opinions analyze compliance standards country development projects provide usable solutions improve management projects according results observed pmbok standard best option followed prince opm standards respectively
article introduces user experience research carried evaluating video illustrated science fiction prototype process control workers essentially prototype remote operator day future control center aimed discovering opportunities new interaction methods ambient intelligence factories future theoretical objective carry experience design research based explicit ambient user experience goals nominated industrial work context article describes complete creative prototyping process starting initial user research included evaluations current work practices technological trend studies design workshops concluding user research assessed final design outcome science fiction prototype main contribution article ambient user experience goals creation process video illustrated science fiction prototype reflection experience driven prototype evaluated two research setups video sequences embedded web survey interviews carried expert process control workers science fiction prototyping process contribution demonstrates method may employ video illustration means future oriented user experience research complementary user centered methods may used validate results
triboelectric nanogenerator teng invented emerging energy harvesting technology efficiently converts ambient mechanical energy electricity much work done develop device improve performance however systematic report applications large scale publication patent data analysis available study use tech mining systematic analytical method based structured texts applied publication patent abstract data analyze potential applications tengs series applications product scale industry scale identified findings show used sensors tengs mostly applicable automation energy intensive industries automotive medical surgical devices consumer electronics household appliances tengs form sensors also integrated future oriented exponentially growing technologies robotics drones nanotechnology bioinformatics create enormous value future economies moreover applications tengs sensors also line current global trends science technology development including internet things big data clean energy smart cities combined technologies industries tengs help tackling challenges global warming environmental pollution security systems suggest teng research community widen interdisciplinary collaboration pursue connections industry file patents progresses addition research limitations future development directions teng pointed
vapor pressure thioacetazone taz determined temperature range transpiration method obtained data used calculate standard molar enthalpy sublimation found mol drug solubility measured seven temperatures modeling solvents octanol hexane aqueous buffers saturation shake flask method using spectrophotometric analysis found taz poor solubility hexane buffer solutions limited solubility octanol experimental data well correlated van hoff modified apelblat equations temperature dependence taz partition coefficient octanol buffer system derived partition coefficient value system logp refers optimal interval oral absorption drugs thermodynamic parameters sublimation solubility solvation transfer determined based experimental data dominant effect enthalpy entropy contributions gibbs energy investigated processes revealed elsevier ltd
currently algerian energy system relies almost exclusively fossil resources new paradigm emerging country algeria program renewable energy energy efficiency established ambitious goal deriving electricity production renewable energy sources res study addresses sustainability objectives program using methodology combines analytic hierarchy process ahp experts feedback evaluate different renewable energy options performance different res options assessed sub criteria reflecting social environmental economic technical concerns results highlighted importance social environmental criteria main drivers obtained final ranking three sub criteria weighting decision process solar power shown particularly well suited algeria outperforming renewable options large set highly weighted criteria wind power ranked second followed biomass geothermal lastly hydropower wind solar power together achieved total score results policy implications drawn directions future research suggested elsevier ltd rights reserved
silk fibroin bombyx mori excellent biocompatibility thus widely applied biomedical field recently various based composite nanofibers developed demanding applications additionally grape seed extract gse demonstrated powerful antioxidation present study dedicate fabricate gse loaded polyethylene oxide peo composite nanofiber green electrospinning results indicated successful loading gse peo composite nanofibers introduction gse affect morphology peo nanofibers gse released nanofibers sustained manner furthermore comparing raw peo nanofibrous mats gse loaded peo nanofibrous mats significantly enhanced proliferation skin fibroblasts also protected damage tert butyl hydroperoxide induced oxidative stress findings suggest promising potential novel gse loaded peo composite nanofibrous mats applied skin care tissue regeneration wound healing elsevier rights reserved
science engineering concepts size scale play key role design many physical phenomena show dependence size objects scale consideration particular interest present study situations dependence system response size appears complex insofar characterized transitions behaviour different scales particular importance connection laboratory specimens full scale objects systems context modem technology increasing interest behaviour nano scale objects opposed macroscopic scaling transitions size effects fracture strength materials structures particular significance modem science engineering boundaries scale mechanical phenomena studied devices exploited expanding one hand towards global scale phenomena towards nanometre scale processes circumstances challenge conventional wisdom acquired many decades according laboratory experiments performed engineering scale sub meters provide source material property data used input modelling scale real object deviations accepted scaling laws found new physical deformation mechanisms need proposed identified new modelling approaches developed validated paper review examples non trivial size dependence address fundamental question efficient description size effects scale transitions functional description multi scaling power law regimes considered functional form suitable task identified form applied variety experimental data manifesting size effects including dual failure strength criteria stress toughness fatigue crack growth thresholds applications context fretting fatigue paris fatigue crack growth law etc
suitable piece software presented connect abaqus sophisticated finite element package matlab comprehensive program mathematical analysis interface well known codes benefits image processing integrated graph plotting features matlab also opens new opportunities results post processing statistical analysis mathematical optimization among many possibilities software architecture usage appropriately described two problems particular engineering significance addressed demonstrate capabilities firstly software employed assess cleavage fracture novel paranieter weibull probabilistic framework potential create train neural networks used identify damage parameters hybrid experimental numerical scheme model crack propagation structural materials means cohesive zone approach source code detailed documentation large number tutorials freely downloaded www abaqusmatlab com elsevier ltd rights reserved
background oropouche virus causes oropouche fever arboviral disease transmitted mainly midges genus culicoides culex mosquitoes clinical presentation oropouche fever humans includes fever headache rash myalgia rare cases spontaneous bleeding aseptic meningitis landscape change proposed driver oropouche fever emergence objective investigate landscape epidemiology oropouche fever outbreak began april cusco peru methods used information vegetation multivariate spatial analyses including ecological niche modeling vegetation characterised using day composite enhanced vegetation index evi images spatial resolution modis sensor carried terra satellite findings cases distributed across seven peruvian districts two provinces concepcion province affected districts evi time series across suggested decline vegetation sites oropouche fever cases epidemic ecological niche modeling suggests areas junin apurimac madre dios departments risk oropouche fever occurrence main conclusions results may provide guide future fieldwork test hypotheses regarding oropouche fever emergence habitat loss tropical latin america
research consistently shown males play violent video games frequently females factors underlying gender gap examined date approach examines assumption males play violent video games anticipate enjoyment less guilt engaging virtual violence females may males less empathetic tend morally justify physical violence greater need sensation aggression video game play females results path model based survey data respondents using multi step multiple mediation analyses confirm assumptions taken together findings study shed light gender gap violent video game use
article reports small scale study examined impact examining indispensable role nonverbal communication overall communicative process english language learning eurasian national university astana kazakhstan second year student specialty foreign languages two foreign languages weeks components nonverbal communication play key role especially subconscious level speech discourse awareness vary culture culture moreover particularly important helping students develop ability understand real environment first theoretical part research defined mostly widely spread components nonverbal communication eye contact facial expression proximity gesture additionally article begins comparing identifying differences foreign target languages fact kazakhstan multilingual multicultural country investigate different components nonverbal communication native foreign languages besides features nonverbal communication take key role communicative competence attention given practical teaching techniques help english language teachers incorporate essential element multicultural classrooms considers interplay gesture facial expression gaze behaviour among interlocutors gives special consideration second language learner obstacles encountered communicating cross culturally thus second practical part study investigates learners use eye contact facial expression proximity gesture communicate conversational settings whether gesturing settings facilitates acquisition beyond immediate context subsequently conducted lessons implementing specific activities video project work digital storytelling interviews hence producing classroom activities stimulate creativity raise students awareness implementing different gestures signs facial expressions customs around significantly contributes successful dialogue cultures research suggests listening activities part comprehension experience components nonverbal communication form large part communicate message even times students unaware furthermore comprehension eye contact facial expression proximity gesture may help comes expressing surprisingly much students understand without ever hearing word results reveal components nonverbal communication effectively facilitate cognitive processes students vividly promote foreign language learning overall findings indicate eye contact facial expression proximity gesture serve productive intellectual aids learning conversational task based settings
previously identified novel intra tumoral dichotomy triple negative breast cancer tnbc based differential responsiveness reporter containing sox regulatory region srr reporter responsive cells stem like reporter unresponsive cells using bioinformatics profiled protein dna binding motifs srr identified myc one potential transcription factors driving srr activity support role myc found highly expressed cells compared cells enforced expression myc cells resulted significant increase srr activity myc dna binding proportion cellsexpressing chemoresistance mammosphere formation knockdown myc using sirna cells led opposite effects also found evidence relatively high erk activation cells contributes high expression myc stem like features using confocal microscopy patient samples found localization myc cell population lastly high proportion myc positive cells tumors significantly correlated short patient survival conclusion inhibition mapk erk myc axis may effective approach eliminating stem like cells tnbc
meniscal integrity prerequisite sustained knee joint health prevention meniscal degeneration main research goal cartilage protective effects selenium described little known impact meniscus therefore investigated influence sodium selenite meniscal explants tumor necrosis factor alpha tnf alpha stimulated proinflammatory conditions meniscal explant disks mmdiameter mmthickness isolated year old cattle incubated tnf alpha sodium selenite low dose lod found insulin transferrin selenium medium supplements medium dose med described physiological synovial concentration high dose hid described optimal serum concentration days culture glycosaminoglycan gag release dmmb assay nitric oxide production griess assay gene expression matrix degrading enzymes quantitative rtpcr apoptosis rate determined tnf alpha led significant raise gag release production lod med selenite significantly reduced tnf alpha induced gag release respectively production respectively apoptosis respectively lod med selenite showed tendency reduce tnf alpha mediated increase inducible synthase inos levels lod selenite furthermore matrix metalloproteinase mmp transcription levels disintegrin metalloproteinase thrombospondin motifs adamts levels lod less pronounced med selenite show substantial impact early meniscal inflammatory response knowledge first study showing protective influence selenium meniscal tissue maintenance understand superior potency low dose selenium molecular level future studies needed
background previous studies shown shaped relationship systolic blood pressure risk cause mortality patients type diabetes renal impairment aims evaluate associations time updated systolic blood pressure time updated change systolic blood pressure follow period risk cause mortality patients type diabetes renal impairment patients methods total patients type diabetes renal impairment swedish national diabetes register followed years time dependent cox models used estimate risk cause mortality time updated mean systolic blood pressure average baseline reported post baseline systolic blood pressures results time updated systolic blood pressuremmhg last two observations associated higher risk cause mortality mmhg hazard ratio confidence interval conclusion low systolic blood pressure decrease systolic blood pressure follow associated higher risk cause mortality patients type diabetes renal impairment
objectives gastro oesophageal reflux dyspepsia felt separate upper gastrointestinal conditions aimed measure degree overlap assess whether endoscopic findings differed material methods demographic symptom upper endoscopy histology data collected consecutive adults secondary care patients categorised according whether reported gastro oesophageal reflux alone dyspepsia alone patient demographics endoscopic findings compared results patients gastro oesophageal reflux alone dyspepsia alone overlap patients overlap symptoms likely smoke compared gastro oesophageal reflux alone dyspepsia alone differences patients gastro oesophageal reflux alone overlap higher prevalence erosive oesophagitis respectively still commonest diagnosis among dyspepsia alone significant differences seen prevalence endoscopic findings conclusions gastro oesophageal reflux dyspepsia symptoms commonly overlap minimal differences demographics spectrum underlying organic disease various symptom groups suggesting restrictive classifications according predominant symptom may clinically useful
accurate image registration vital step many computer vision processes however traditional sift based methods able obtain satisfactory results cases paper turn matching problem markov random field mrf optimization problem propose fast accurate image registration method based message passing screen mismatches caused conventional sift based algorithm proposed method comprises three steps first sift detector used detect key points points described daisy instead sift detector improve efficiency second new geometric constraint distance direction terms designed incorporated sequential tree reweighted message passing trw obtains coarse matching result finally ransac algorithm adopted filter mismatches obtain accurate transformation experimental results demonstrate proposed method significantly improves efficiency accuracy registration process secures desirable result
people perception environmental socio economic impacts due three hydro electric projects heps commissioned construction studied north west indian himalaya surveys among project affected people paps using checklist impacts indicate among negative impacts decrease flora fauna agriculture flow river aesthetic beauty increase water pollution river bed quarrying sand stone human settlement river banks social evils among positive impacts increase standard living road connectivity means transport public amenities tourism environmental awareness related heps paps tend forget negative impacts age heps becomes functional positive impacts seem outweigh negative impacts study concludes difficult separate compounding impacts due hep construction anthropogenic natural factors absence cause effect analyses hard dispel prevailing notion heps undesirable study area led agitations environmentalists stopped construction one heps overcome situation multi disciplinary scientific studies involving paps need carried planning decision making make heps environment friendly sustainable region also need adopt low carbon electric power technologies promote decentralized energy strategy joint ventures public private companies utilizing locally available renewable energy resources
ultra precision manufacturing upm machines used fabricate measure complex parts micrometer level features nanometer level tolerances surface finishes therefore random vibration machine due ground excitations residual vibration stemming onboard disturbances must mitigated using vibration isolation systems long standing rule thumb vibration isolation system design locate isolators way vibration modes isolated machine decoupled however prior work authors demonstrated coupling vibration modes passively isolated upm machines could provide conditions drastic reduction residual vibrations compared decoupling authors analysis based restrictive assumption isolated machine modally damped key contribution paper investigating effect mode coupling residual vibrations upm machines non proportional damping realistic modal damping also analyzes effects mode coupling reduction ground vibrations transmissibility analyses reveal even though damping changes vibration behavior machine compared modal damping mode coupling still provides ample opportunities reduce residual vibration transmissibility guidelines properly designing upm machine best exploit mode coupling vibration reduction provided validated simulations experiments reduction residual vibration reduction transmissibility demonstrated elsevier inc rights reserved
study used gestalt theory examine effects colour similarity blurring boundary banner advertising web page content well colour similarity elicit unconscious scanning behaviour improve attitudes towards brands advertised using banner advertising pre attention stage eye tracking device used record analyse participants eye movement psychological scale used measure participants brand attitudes results suggested using banner advertisements background colours similar web page content increases fixation time fixation count addition results revealed longer fixation time higher fixation count increase positive attitudes towards brand advertised banner advertisement results clarify relationship unconscious exposure brand attitudes provide physiological information relevant commerce
although evidence heterogeneity asthma accumulated consensus definitions asthma phenotypes still lacking obesity may heterogeneous effects various asthma phenotypes aimed distinguish asthma phenotypes latent class analysis investigate associations different obesity parameters adults using population based swiss cohort sapaldia applied latent class analysis self reported asthmatics using information disease activity atopy age onset associations obesity examined multinomial logistic regression adjustments age sex smoking status educational level study centre body mass index percent body fat waist hip ratio waist height ratio waist circumference used obesity measure four asthma classes identified including persistent multiple symptom presenting asthma symptom presenting asthma symptom free atopic asthma symptom free non atopic asthma obesity positively associated symptom presenting asthma classes symptom free ones percent body fat showed strongest association persistent multiple symptom presenting asthma observed heterogeneity associations obesity across asthma classes indicating different asthma aetiologies authors published elsevier ltd
virtual simulated environments provide multiple ways testing cognitive function evaluating problem solving humans woollett use interactive technology increasingly become essential part modern life autonomously driving vehicles global positioning systems gps touchscreen computers chinn fairlie brown many nonhuman animals forms technology chimpanzees create use tools captive animal environments opportunity actively participate interactive technology often made available exceptions found state art zoos laboratory facilities mallavarapu kuhar interactive technology available captive animals often selectively choose engage enhances animal sense control immediate surroundings clay ackerman self efficacy may help fulfill basic requirements species daily activities using problem solving involve foraging goal oriented behaviors also assists fulfilling strong underlying motivation contrafreeloading exploration expressed behaviorally many species captivity young moreover able present nonhuman primates virtual reality environments experimental conditions provides opportunity gain insight navigational abilities spatial cognition allows insight generation application internal mental representations landmarks environments multiple conditions small large scale space subsequent spatial behavior paper reviews methods using virtual reality developed investigate spatial cognitive abilities nonhuman primates great apes particular comparison humans multiple age groups make recommendations training best practices also pitfalls avoid
inflammatory breast cancer aggressive form breast cancer shows distinct clinical features non inflammatory breast cancer genomic understanding inflammatory breast cancer shed light biological targets disease objective identify targeted hotspot mutations using multiplex genome sequencing inflammatory breast cancer compare findings patients non inflammatory breast cancer recognize novel targets studied patients metastatic breast cancer somatic hotspot mutation testing using gene multiplex platform march december among population patients inflammatory breast cancer patients non inflammatory breast cancer tested total samples patients inflammatory breast cancer average number mutations per patient higher inflammatory breast cancer non inflammatory breast cancer respectively identified somatic mutations inflammatory breast cancer pikca erbb erbb mutations significantly prevalent inflammatory breast cancer non inflammatory breast cancer patients erbb mutations hormone receptor primary tumors pikca erbb detected three major somatic mutations metastatic inflammatory breast cancer patients inflammatory breast cancer pikca mutations mirrored previously reported data metastatic non inflammatory breast cancer first report higher frequency erbb mutation inflammatory breast cancer especially subtype validated larger cohort inflammatory breast cancer patients novel finding could lead development treatments inflammatory breast cancer
backgroundtwo important influences students evaluations teaching relationship professor effects relationship effects reflect unique matches students professors professors unusually effective students others professor effects reflect inter rater agreement professors effective others average across students aimswe attempted forecast students evaluations live lectures brief video recorded teaching trailers sampleparticipants college students female enrolled introductory psychology courses public university great lakes region united states methodsstudents viewed trailers early semester attended live lectures months later subgroups students viewed professors statistical analyses could isolate professor relationship effects resultsevaluations influenced strongly relationship professor effects students evaluations live lectures could forecasted students evaluations teaching trailers could forecast individual students would respond unusually well specific professor relationship effects could also forecast professors elicited better evaluations live lectures average across students professor effects professors elicited unusually good evaluations students also elicited better memory lectures students conclusionsit appears possible forecast relationship professor effects teaching evaluations presenting brief teaching trailers students thus might possible develop online recommender systems help match students professors unusually effective teaching emerges
data computational domain stored digital format format data consumes less effort storage thus number organization institutes preserving information format presented work data privacy main area study proposed work organization considered decisions made different department based data attributes additionally make decisions attributes departments required departments able disclose privacy data owner therefore combine data attributes mining combined data need privacy preserving technique preventing privacy issues centralize database paper demonstrate different departments organization combine data without harming privacy client making effective decisions efficient accurate manner thus method vertically data combination cryptography decision mining demonstrated mine decisions data decision tree used implementation proposed privacy preserving data mining decision making technique performed using java technology additionally performance system computed terms accuracy error rate memory consumption time consumption finally justify outcomes proposed data mining technique traditional tree using weka tool used data comparative performance study experimental results show effective performance security given privacy preserving technique
main focus research develop accurate real time method fault detection analysis hvb high voltage class transmission lines current voltage signals oscillographic records acquired distance protections relays minimum impedance installed electrical network sonelgaz algerian company electricity gas method deals evaluation detail spectrum energy dse calculated discrete wavelet transform dwt applied current phases moving data windows length equivalent one cycle fundamental power frequency fault detection algorithm processed first scale superimposed fault current signals phases ground sharp variation dse existing methods treat disturbances faults simultaneously exist transmission line single type proposed method ability discriminate disturbances faults study compared powerful analysis protection fault records sigra software determining start fault inception clearing time performance method tested evaluated real data records accurately detect fault within half cycle instant fault occurrence elsevier ltd rights reserved
thrombocytosis frequent laboratory finding diagnosis therefore elevated platelet counts require careful diagnostic work differentiate reactive thrombocytosis caused various conditions essential thrombocythemia myeloproliferative neoplasm mpn either setting aspirin widely used clinical practice however even platelet counts never shown cause thrombosis bleeding due acquired von willebrand factor defects association high platelet counts identification reactive conditions appropriate therapy underlying disorder relevant contrast related mpn associated thrombosis hemorrhage current recommendations suggest use low dose aspirin patients unless contraindicated however strength recommendation weak evidence level ilb grade potential benefit aspirin used primary thromboprophylaxis mostly derived eclap study polycythemia vera however translating study results appears highly questionable may biased absence robust data regarding benefit risk balance aspirin appears reasonable stratify patients according individual thrombotic bleeding risk restrict use aspirin high risk categories patients microcirculatory disturbances test pharmacological efficacy cox inhibition measurement txb modify aspirin dosing regimen twice instead daily required
following failure phase clinical study evaluating human retinal pigment epithelial hrpe cell implants potential treatment option parkinson disease speculation centered implant function survival possible contributors therapeutic outcomes recently reported neonatal hrpe cells similar hrpe cells used phase clinical study produced short lived vitro limited vivo trophic factors supports assumption hypothesize switch fetal neonatal hrpe cells phase phase clinical trial may partly responsible later negative outcomes investigate hypothesis used two neonatal hrpe cell lots prepared similar manner neonatal hrpe cells used phase clinical study compared previously evaluated fetal hrpe cells behavioral changes following unilateral striatal implantation hydroxydopamine lesioned rats results showed fetal neonatal hrpe cell implants able improve behavioral outcomes following striatal implantation lesioned rats data suggest fetal hrpe cells may preferential neonatal hrpe cells restoring behavioral deficits
evaluating link prediction methods hard task large complex networks due prohibitive computational cost however consider lower bound node pairs similarity scores task greatly optimized paper study index bounded link prediction framework applicable enormous heterogeneous networks specifically propose fast algorithm based parallel computing scheme obtain node pairs values larger lower bound furthermore propose general measurement called self predictability quantify performance similarity indices link prediction also indicate link predictability networks respect given similarity indices elsevier rights reserved
since decades basic changes century electrical power grid fulfilled additive technologies past one emergence smart grid new concepts addresses challenge existing electrical networks new technologies infrastructure enhance efficiency performance reliability electrical power grid definition smart grid accomplished new control automation techniques modern communications infrastructure based sensing metering monitoring modern energy management technologies considering demand optimization energy system availability libyan electrical network electrical system suffering many problems modernized meet smart grid requirements least ready interfacing modernized electrical networks main objectives paper provide contemporary look current state libyan power grid discus well requirements considered network smart grid also initiate open research issues field applications libyan power grid among research community start practical steps smart grid road map libyan electric system published elsevier
politicians right generally physically attractive politicians left one suggested explanation politically right leaning people generally attractive another selection electoral candidates right dependent candidate attractiveness assess two explanations attractiveness right left leaning scholars identified authorship prominent ideologically toned intellectual magazines compared contrast politicians scholars would generally expected benefit much physical attractiveness would effects attraction selection scholarly career expected differ depending political ideology perceived political orientation scholars accurate predictor magazine political orientation physical attractiveness controlling grooming better groomed scholars likely appear right leaning journals physically attractive scholars likely appear left leaning journals results suggest reason politicians right physically attractive politicians left selection electoral candidates political right dependent candidate attractiveness ideologically right leaning people generally look better elsevier ltd rights reserved
background hamstring injury common muscular lesion athletes conservative treatment well described surgical management often indicated proximal tendinous avulsions knowledge surgical treatment proposed failure conservative treatment musculotendinous hamstring lesions purpose describe surgical management proximal distal hamstring musculotendinous junction lesions professional athletes failure conservative treatment study design case series level evidence methods consecutive series professional athletes including soccer players rugby players handball players underwent surgical intervention october june treatment recurrent musculotendinous hamstring injuries athletes failed least months conservative treatment recurrent musculotendinous hamstring injury surgical resection musculotendinous scar tissue performed using longitudinal muscular suture lower extremity functional scale lefs marx scores obtained month follow final phone interview completed determine recurrence hamstring injury return previous level play results mean age surgery years range years musculotendinous hamstring lesions involved semitendinosus biceps femoris injuries located proximally distally conservative treatment lasted mean months range months last recurrence patients average range separate incidents injury recurrence surgical intervention decided upon month follow patients marx activity scores lefs scores patients returned level play mean months range months mean follow months none athletes suffered recurrence surgical complication encountered conclusion cases failed conservative treatment musculotendinous hamstring lesions surgical intervention may viable treatment option professional athletes allows patient return level play
nearly women almost poor women low income countries died pregnancy related complications represents decline since estimated half million women died year still far higher aims set united nations millennium development goals mdgs turn century witnessed shift near complete neglect issue emergence network individuals organizations shared concern reducing maternal deaths growth number organizations governments maternal health strategies programmes maternal health experienced marked change agenda status attracting significantly higher level attention world leaders greater resource commitments one issue addressed billion pledges global strategy women children health ever several differences network actor features issue characteristics policy environment pre post help explain change agenda status global maternal mortality reduction significantly strong poverty reduction norm emerged turn century represented united nations mdgs framework norm set unusually strong expectations international development actors advance included issues norm grew drew policy attention maternal health goal mdg seeking advance goals agenda world leaders launched initiatives addressing maternal child health new network governance framing strategies closely linked maternal newborn child health shaped initiatives diverse network composition expanding beyond relatively narrowly focused technically oriented group encompass allies leaders brought additional resources bear problem crucial maternal health rise agenda
main aim work investigate electronically adjustable properties discussed simple transfer sections pass bilinear filters practical verification signal flow graph sfg approach used better understanding circuit design principle simultaneous separated control zero pole frequencies available thus circuit favorable design classical special applications constant phase elements blocks fractional order synthesis interesting example operation two port block called half integrator approximation constant phase character shift given intentions supported pspice simulation results prepared active elements modeled cmos transistor level low voltage tsmc epi process also experimental laboratory tests employing commercially available active elements elsevier gmbh rights reserved
review discusses recent advances materials engineering control thermal conductivity begin presenting theories heat conduction general material classes focusing common approximations trends next discuss characterization techniques measuring thermal conductivity underlying transport properties advanced materials frontiers thermal transport rattlers complex unit cells nanowires nanocomposites treated depth using experimental data theoretical predictions review closes highlighting several promising areas development
maternal rumination cognitive affective trait could influence offspring ability respond flexibly positive negative events depending quality maternal problem solving behaviors rumination occurs reward circuitry sensitive stressors related risk depression reward circuitry appropriate candidate mechanism maternal characteristics influence offspring evaluated independent combined effect maternal rumination disengagement adolescent neural response reward win loss participants boys mothers low income urban backgrounds followed prospectively longitudinal study combination high maternal rumination child age high maternal disengagement problem solving child age associated lower anterior cingulate response winning reward age unrelated neural response losing reward lower anterior cingulate response winning reward associated fewer anxiety symptoms late adulthood findings suggest maternal rumination occurring within context maternal disengagement challenging experiences may related offspring blunted engagement positive events helping highly ruminative mothers restructure repetitive negative thoughts develop context appropriate problem solving behaviors may important promoting offspring affective development
hypercalcemia cause renal dysfunction nephrogenic diabetes insipidus ndi mechanisms underlying hypercalcemia induced ndi well understood elucidate early molecular changes responsible disorder employed mass spectrometry based proteomic analysis inner medullary collecting ducts imcd isolated parathyroid hormone treated rats onset hypercalcemia induced ndi forty one proteins including water channel aquaporin exhibited significant changes abundance decreased bioinformatic analysis revealed many downregulated proteins associated cytoskeletal protein binding regulation actin filament polymerization cell cell junctions targeted immunoblot studies confirmed downregulation proteins identified initial proteomic analysis additional experiments using vitamin treatment model hypercalcemia induced ndi evaluation transcript levels estimated half life downregulated proteins suggested enhanced protein degradation possible regulatory mechanism electron microscopy showed defective intercellular junctions autophagy imcd cells vitamin parathyroid hormone treated rats significant increase number autophagosomes confirmed immunofluorescence labeling colocalization lamp aquaporin downregulated proteins found models immunogold electron microscopy revealed aquaporin autophagosomes imcd cells hypercalcemia models finally parathyroid hormone withdrawal reversed ndi phenotype accompanied termination aquaporin autophagic degradation normalization nonphoshorylated phosphorylated aquaporin levels thus enhanced autophagic degradation proteins plays important role initial mechanism hypercalcemic induced ndi
paper addresses need enhance transparency ambient intelligent environments developing natural ways interaction allow users communicate easily hidden networked devices rather embedding obtrusive tablets computing equipment throughout surroundings ambient intelligence vision aims realize digital environments adapt users responsive transparent context aware manner order enhance users comfort therefore appropriate employ paradigm computing words cwws aims mimic ability humans communicate transparently manipulate perceptions via words one daily activities would increase comfort levels users especially people disabilities cooking performing tasks kitchen existing approaches food preparation cooking recipe recommendation stress healthy eating balanced meal choices providing limited personalization features use intrusive user interfaces herein present application transparently interacts users based novel cwws approach order predict recipe difficulty level recommend appropriate recipe depending user mood appetite spare time proposed cwws framework based linear general type lgt fuzzy sets linearly quantify linguistic modifiers third dimension order better represent user perceptions avoiding drawbacks type interval type fuzzy sets lgt based cwws framework learn user experiences adapt order establish natural human machine interaction carried numerous real world experiments various users university essex intelligent flat comparison analysis interval type fuzzy sets lgt fuzzy sets demonstrates improvement general type fuzzy sets used interval type fuzzy sets used instead quantitative qualitative analysis show success system providing natural interaction users recommending food recipes quantitative analysis shows high statistical correlation system output users feedback qualitative analysis presents social science evaluation confirming strong user acceptance system
paper reports study impact different usage patterns automated blinds system energy consumption heating cooling dutch office building five month observational field study offices resulted dataset blinds usage four types blind users data used simulate effect blinds usage energy consumption heating cooling results field study show majority building occupants switched automatic mode blinds system permanently simulation results indicate significantly impacts energy consumption building total daily average energy consumption heating cooling significantly lower occupants using automatic mode three groups manual users day versus day
evolution human eye unique high contrast morphology allows people communicate simple look yet overt looking always preferred social situations covert shifts attention occur without concomitant shift eyes head support need present field study discretely recorded pedestrians looks confederate performed action raising hand side head saying hey phone private action raising hand side head greeting static wave saying hey public action critically pedestrians looking confederate start action despite pedestrians looked response public action wave private action phone argue observed difference looking responses must due pedestrians first attending confederate covertly order assess intention action signaling attention look socially appropriate respond public action though functional utility covert attention rarely considered outside controlled laboratory tasks results provide first demonstration covert attention plays critical role guiding appropriate social looking behaviour elsevier inc rights reserved
aim special issue deepen understanding role moral emotions play organisations part wider discourse organisational ethics morality unethical workplace behaviours far reaching consequences job losses risks life health psychological damage individuals groups social injustice exploitation even environmental devastation consequently determining ethical transgressions occur surprising regularity despite inhibiting influence moral emotions considerable theoretical practical significance management scholars managers alike introduction present core arguments field notably effect organisational life bureaucracy emotions general moral emotions particular moral standing leaders managers followers moral challenges raised obedience resistance organisational power ethical blindspots induced may appear deeply moral emotions issues explored collection geographically diverse articles various work contexts thematically organised terms moral emotions ethical behaviour social pressure moral emotions consequences within across levels analysis iii psychoanalytic perspectives management moral emotions virtue moral emotions moral emotions action tendencies end suggesting certain avenues future research hope endeavour initiated inspire improved practice work
objective aim study understand association women reproductive history risk developing type diabetes hypothesized characteristics signifying lower cumulative endogenous estrogen exposure would associated increased risk methods prospective cohort analysis postmenopausal women aged years women health initiative whi determined age menarche final menstrual period history irregular menses questionnaires baseline calculated reproductive length age menarche final menstrual period presence new onset type diabetes self report using multivariable cox proportional hazards models assessed associations reproductive variables incidence type diabetes results age adjusted models women shortest reproductive periods greater risk developing type diabetes women medium length reproductive periods women longest reproductive periods higher risk women medium length periods associations attenuated full adjustment shortest longest compared medium duration final menstrual period age age increased risk diabetes respectively compared age final menstrual period years timing menarche cycle regularity associated risk full adjustment conclusions reproductive history may associated type diabetes risk women shorter longer reproductive periods may benefit lifestyle counseling prevent type diabetes
brief overview vortex induced vibration viv bridge decks presented highlighting special viv features concerning bridge decks popular viv model van der pol type model bridge decks examined detail alternatively truncated volterra series based nonlinear oscillator introduced model viv system typical features viv limit cycle oscillation lco frequency shift hysteresis beat phenomenon parsimoniously accurately captured proposed nonlinear model functional expansion nonlinear system volterra series convenient estimating linear nonlinear contributions viv demonstrated relative contribution nonlinear effects viv around total response range bridge cross sections efficacy volterra series reduced order model rom capturing aerodynamic nonlinearities eliminates need reliance conventional phenomenological models promises offer unified framework nonlinear wind effects long span bridgesfor example viv buffeting flutter american society civil engineers
studies examined association smoking behavior especially quitters time diagnosis mortality among cancer patients objective examine benefits quitting cause mortality among cancer patients eligible cancer patients diagnosed identified hospital based cancer registry japan followed years evaluated smoking behavior cancer diagnosis especially recent quitters current smokers association cause mortality using cox proportional hazards models covariates adjusted survival curves risk death estimated reduced recent quitters compared current smokers according adjusted survival curves median survival time years recent quitters versus years current smokers indicating absolute difference year median survivor similarly never former smokers lower risk death years years gained respectively compared current smokers addition former never smokers recent quitters showed consistently higher survival rates current smokers year calendar period diagnosis among cancer patients recent quitters may similar patients stop smoking shortly cancer diagnosis terms smoking duration latter may able decrease risk death suggesting smoking cessation could part cancer care
cardiac electrogram egm signals electrophysiologic characteristics derived amplitude timing central diagnosis therapeutic management arrhythmias bipolar egms often used possess polarity shape dependence catheter orientation contributing uncertainty objective describe novel method map cardiac activation resolves signals meaningful directions insensitive electrode directional effects methods multielectrode catheters span space used derive local electric field field signals traveling wave model local egm propagation motivates new omnipolar reference frame understand egm field signals provide bipolar component egms aligned anatomic physiologic directions validate basis technology determine accuracy using saline tank simulate physiologic propagation results omnipole signals healthy tissue nearly free catheter orientation effects constrained biophysics consistent morphologies thus consistent measured amplitudes timings using mapping system traveling wave treatment omnipolar technology field loops derived new nearly instantaneous means determine conduction velocity activation direction conclusion describe basis validate ablation mapping catheters saline tank finally illustrate signals live subjects significance novel approach signal processing real time visualization allows newly detailed characterization myocardial activation insensitive catheter orientation
ability attribute represent others mental states beliefs called theory mind essential participation human social interaction despite considerable body research using tasks protagonists participants attentional focus held false true beliefs question automatic belief attribution bystander agents received little attention current study presented adults year olds implicit computer based avoidance false belief task participants asked place object one three boxes manipulated beliefs irrelevant human like non human like bystander agent visible screen importantly bystander agent beliefs irrelevant solving task still children decision making significantly influenced bystander agent beliefs even non human like self propelled object influence become obvious adults deliberate decisions occurred reaction times suggests also processed bystander agent beliefs able suppress influence beliefs behavior regulation results control study ruled low level explanations confirmed self propelledness agents necessary factor belief attribution occur thus humans spontaneously ascribe beliefs self propelled bystander agents beliefs even influence meaningful decisions children elsevier inc rights reserved
age related changes testosterone believed key component processes contribute cognitive aging men apoe epsilon allele may interact testosterone moderate hormone association cognition goals present study examine degree free testosterone associated episodic memory community based sample middle aged men examine potential interaction free testosterone apoe epsilon allele data used participants vietnam era twin study aging average age years standard deviation significant positive associations observed free testosterone level verbal episodic memory well significant interaction free testosterone apoe epsilon status epsilon carriers free testosterone positively associated verbal episodic memory performance story recall whereas association observed epsilon noncarriers results support hypothesis apoe epsilon status increases susceptibility risk factors low testosterone may ultimately contribute cognitive decline dementia elsevier inc rights reserved
present brief survey history development mechanical theories strength materials advantages drawbacks physically reliable experimentally justified criterion equivalence quasihomogeneous materials established structure criterion determined according results analysis equation limiting surface whose shape satisfies necessary sufficient requirements imposed principal regularities postulates mechanics deformed body corresponding equation contains invariants used control shear tensile fracture degrees responsibility mechanisms put correspondence parameter plasticity material appearing equation form weight coefficient determined according results testing tension compression condition limiting state materials inhomogeneous structure established introducing criterion influence function taking account statistical aspects strength materials connection presence weak places defects analysis structure influence function reduced solution problem probability theory repeated sampling given volume
model describing unidimensional anisothermic deformation allowing damage material presented effect stresses temperature creep strain rate variations evaluated scalar function damage validity approach demonstrated creep description steel within rather wide stress temperature ranges
backgroundfew efficacious early treatments post traumatic stress disorder ptsd children adolescents exist previous trials intervened within first month post trauma focused secondary prevention later post traumatic stress however considerable natural recovery may still occur months post trauma trials addressed early treatment established ptsd months post trauma methodstwenty nine youth years ptsd according age appropriate dsm icd diagnostic criteria single event trauma previous months randomly allocated cognitive therapy ptsd ptsd waiting list weeks resultssignificantly participants free ptsd ptsd posttreatment intent treat difference ptsd yielded greater improvement child report questionnaire measures ptsd depression anxiety clinician rated functioning parent reported outcomes recovery ptsd maintained month posttreatment beneficial effects ptsd mediated changes appraisals safety seeking behaviours predicted cognitive models ptsd ptsd considered acceptable basis low dropout high treatment credibility therapist alliance ratings conclusionsthis trial provides preliminary support efficacy acceptability ptsd early treatment ptsd youth moreover trial support extension watchful waiting month post trauma window significant improvements arm particularly terms functioning depression observed replication larger samples needed attention recruitment issues required
invention technical field areas photovoltaic solar panel electricity production desertation ground effect forthcoming extensive use solar panels rainwater harvesting irrigation ground fertilization main idea invention collect rainwater lower edge photovoltaic panel store tank water subsequently irrigate land agriculture use collect local away water use refrigerate photovoltaic back front panel clean glass panel surface results soil cultivation plant animal production greenhouse effect improvement photovoltaic panel lower temperature efficiency photovoltaic front panel glass cleaning better efficiency process handled plc programmable logic computer according desired use system configurations lake reservoir fill animal farm irrigation back cooling front glass cooling dual cooling front glass cleaning full feature system
basic question computational geometry find relationship set points line real plane paper present multidimensional data structures points allow answering following queries given input line estimate log time number points line return log time points line return log time point closest line illustrate utility computational question gis applications air defense traffic control
purpose literature organizational analysis identified project participants certain impact project outcome however study identifies impact project teams individual project participants green building project purpose paper analyze impact green building project teams green building certification design methodology approach project information project team information green building certification grade collected using canadian green building database project team data analyzed organizations ranked based green building project experience collaborations experienced green building organizations page rank algorithm used calculate rank organizations order identify impact organizational rank final green building certification grade project findings results show positive relationship green building certification grade number organizations green building experience project team results also show experienced key organizations owners designers contractors likely lead lower green building certification grade originality value impact project teams green building projects studied study used innovative method analyze green building project teams investigate importance green building project experience findings study provided evidence support influence project team compositions green building projects results presented paper help project owners managers project team formation successful execution green building projects
men congestive heart failure chf relatively low testosterone levels several studies demonstrated testosterone treatment increases cardiac output reduces peripheral vascular resistance however effects testosterone heart function cardiomyocyte apoptosis ventricular remodeling fully elucidated study conducted investigate effects testosterone heart function cardiomyocyte apoptosis ventricular remodeling male rats post myocardial infarction total male rats randomly assigned undergo ligation coronary artery pseudosurgery weeks left ventricular ejection fraction lvef defined successful model chf model rats randomly assigned groups namely low dose testosterone high dose placebo groups treatment weeks expression several mrna transcripts myocardial tissue measured quantitative polymerase chain reaction immunofluorescence used measure myocardial caspase expression compared group lvef significantly improved treatment groups moreover mrna expression atrial natriuretic peptide brain natriuretic peptide matrix metalloproteinase sarcoendoplasmic reticulum atpase significantly reduced mrna expression glycogen synthase kinase tissue inhibitor metalloproteinase markedly increased groups treatment also significantly reduced caspase expression therefore different doses suppressed ventricular remodeling improved left ventricular function reduced apoptosis prevented mortality chf rat model
previous studies demonstrated short wavelength sensitivity acute alerting effects light biological night fewer studies assessed alerting effect light daytime study assessed wavelength dependent sensitivity acute alerting effects daytime light exposure following chronic sleep restriction young adults men women mean years participants restricted time bed night laboratory admission time bed laboratory aligned wake time participants randomized exposure total either narrowband blue max green light max equal photon densities photons sec beginning waking compared darkness control lux subjective sleepiness karolinska sleepiness scale sustained attention auditory psychomotor vigilance task mood profile mood states polar form working memory back task selective attention stroop task polysomnographic ocular sleepiness measures optalert assessed prior light exposure found significant effect light wavelength measures exception single mood subscale research needed optimize characteristics lighting systems induce alerting effects daytime taking account potential interactions homeostatic sleep pressure circadian phase light responsiveness
past years power quality monitoring become important topic negative impact different machines electrical network susceptibility critical equipment different disturbances affect therefore order apply proper solution correctly detected classified general signal processing techniques applied detection recently several approaches based empirical mode decomposition emd method reported however selection best suited method terms processing performance particular case complicated decision making process paper quantitative qualitative comparative study using emd methods conventional emd ensemble emd complete ensemble emd presented study applied synthetic real signals aspects computational cost decomposition accuracy discussed
big data term jumped overnight roots described innovative technique technology save distribute manage visualize analyze larger sized data extreme velocity methods manage unstructured structure incapable amount data big data high capacity predict conclusion low cost consumption increase efficiency enhance decision making various fields like finance management fraud control improve business transaction existing system amount customers services online transaction grown rapidly often suffer scalability inefficiency problems processing analyzing large scale data nowadays fraud transactions real time increasing identifying large scale patterns across many transactions detecting anomalous behavior individual user change fraudulent online transaction thus banks turning analytics predict prevent fraud real times fraud detection traditionally focused factors known bad addresses unusual login times project proposed system deals credit debit card management improve scalability efficiency big data environment implemented hdfs hadoop distributed file system widely adopted distributed computing platform using map reduce parallel processing paradigm stores large files typically range gigabytes terabytes across multiple machines hand nowadays fraudulent web attacker increased steel password order overcome proposed system implements syferlock concept add security credit card transaction changes include stronger user authentication tool syferlock require associates follow new steps logging network remotely syferlock patented random number generation authentication solutions provide next generation one time passwords pins otps secure access computers networks internet syferlock engineered enhanced authentication methodology system using device less otps provides users simple secure way access information leveraging existing passwords uses one time password expired used added security strengthens ability protect applications systems
study sought determine minimal serum hydroxyvitamin concentration required maintain bone health postmenopausal women low bone mass serum concentration rather appropriate bone health consensus minimal serum hydroxyvitamin concentration required maintain bone health aim study investigate relationship measured via liquid chromatography mass spectrometry current gold standard biochemical markers bone turnover pth bone mineral densitometry bmd medical records postmenopausal women newly diagnosed osteoporosis osteopenia samsung medical center investigated subjects divided four groups according serum concentration serum concentrations bone specific alkaline phosphatase alp carboxy terminal cross linking telopeptide type collagen ctx intact pth ipth bmd compared among four groups using analysis covariance thresholds assessed using spline plots locally weighted regression smoothing loess plots negatively correlated serum alp ctx ipth femur neck total femur bmd significant positive relationships cutoff values estimated spline plots femur neck total femur bmd respectively ipth loess plot showed steep decrease serum concentration followed plateau according study serum concentration rather appropriate bone health
study theprenatal development skull first trimester pregnancy buffalo bubalus bubalis conducted department veterinary anatomy college veterinary science tirupati total buffalo embryos foetii starting day collected different slaughter houses specimens fixed processed serial paraffin sectioning sections subjected different staining methods earliest indication skull development first recognized mass dense mesenchyme enveloping cranial end notochord days followed formation basal plate days ossification skull first appeared mandible maxilla malar bones days chondrocranium cartilaginous days chondrocranium began ossify first days basioccipital exoccipital sphenoid tympanic bulla skull ossified days gestation buffalo period proper feeding mother farmers advised
article describes features servo amplifier developed nru mpei use multi axis high precision materials processing simplified structure servo amplifier key components servo drive digital control system presented two ways multi axes control compared using interface digital inputs outputs using canopen standard based digital protocol benefits multi axis control canopen protocol high speed exchanges reliability data transmission standardization simple communication topology
background objectives dental caries important healthcare challenge adults years age integration oral health screening non dental primary care practice may improve access preventive dental care vulnerable populations elderly integration would require easy fast accurate early caries detection tools primary goal study evaluate diagnostic performance optical coherence tomography oct imaging detecting early caries elderly living community based settings international caries detection assessment system icdas served gold standard secondary goal study provide baseline prevalence data early caries lesions independent living adults aged years materials methods seventy two subjects recruited three sites southern california retirement community senior health fair convalescent hospital clinical examination performed using icdas visual criteria followed oct imaging two dimensional oct images scan analyzed simple software locations log back scattered light intensity bsli scored sound areas equaling exceeding bsli considered carious diagnostic performance oct imaging compared icdas score results oct based diagnosis demonstrated good sensitivity good specificity dentate subjects least one tooth early coronal caries conclusions early coronal decay prevalent unrestored pits fissures coronal surfaces teeth independent living adults aged years though oct imaging coupled simple diagnostic algorithm accurately detect areas early caries community based settings existing devices expensive well suited use non dental health care providers simple inexpensive fast accurate tools early caries detection field health care providers working non traditional settings urgently needed support inter professional dental health management wiley periodicals inc
among preeclampsia related long non cording rnas lncrnas screened gene chip preliminary study attracted attention high conservation across different species significant positive correlation preeclampsia literature bioinformatics analysis suggested lncrna might associated cell growth invasion apoptosis expression severe preeclamptic placentas normal placentas evaluated real time reverse transcription polymerase chain reaction qrt pcr constructed silencing lentivirus vector sirna explore biological function development progression htr svneo trophoblast cells vitro furthermore utilized cck analysis transwell invasion assay flow cytometry determine role proliferation invasion apoptosis htr svneo trophoblast cells proteins related proliferation pcna invasion mmp timp apoptosis caspase bcl evaluated western blot assay results showed obvious upregulation expression preeclamptic placental tissues addition silencing enhanced cell proliferation invasion reduced cellular apoptotic response taken together findings suggest first time abnormal expression lncrna may lead aberrant biological behavior htr svneo cells therefore propose novel lncrna molecule might contribute development might represent potential diagnostic therapeutic target disease wiley periodicals inc
objective aim study assess current status female pelvic medicine reconstructive surgery fpmrs canada including level training practice patterns barriers practice opinions among obstetrician gynecologists gyns urologists methods electronic surveys distributed gyns society obstetricians gynaecologists canada urologists canadian urological association results complete responses collected gyns urologists gyn respondents generalists gen completed fpmrs fellowship training fpmrs gyn gyn gens less likely fpmrs gyns report comfort pelvic organ prolapse quantification assessment urodynamic testing cystoscopy treatment mesh complications management overactive bladder urologists less likely fpmrs gyns report comfort completing pelvic organ prolapse quantification assessment fitting pessaries treating mesh complications likely report comfort managing overactive bladder fpmrs gyns likely providers report high volumes cases past year vaginal hysterectomy well incontinence prolapse procedures gyn gens urologists frequently cited lack formal training residency barrier performing fpmrs procedures whereas fpmrs gyns reported lack operating room facilities support personnel overall respondents opinion fpmrs credentialed canadian subspecialty fpmrs gyn gyn gen urologists conclusions gyn gens reported low case volumes cited inadequate training residency barrier surgically managing pelvic floor disorders respondents felt fpmrs credentialed subspecialty
computationally efficient spray model presented simulation transient vaporizing engine sprays applied simulate high pressure fuel injections constant volume chamber mixture preparation experiments light duty internal combustion engine model based lagrangian particle eulerian fluid approach improved blob injection model used removes numerical dependency injected number computational parcels atomization modeled hybrid kelvin helmholtz rayleigh taylor scheme combination drop drag model includes mach number knudsen number effects computationally efficient drop collision scheme presented tailored large numbers parcels using deterministic collision impact definition tree data search structure perform radius influence based grid independent collision probability estimations near nozzle sub grid scale flow field representation introduced reduce numerical grid dependency uses turbulent transient gas jet model stokes strouhal analogy assumption implicit coupling method developed arbitrary lagrangian eulerian ale turbulent flow solver multi objective genetic algorithm used study interactions various model constants provide optimal calibration optimal set showed similar values primary breakup constants values used literature however different values seen gas jet model constants accurate simulations initial spray transient results show direct correlation predicted initial liquid phase transient global gas phase jet penetration model validation also performed engine simulations set constants model captured mixture preparation well cases proving suitability simulations transient spray injection engines elsevier ltd rights reserved
accurate machine design adequate metrology loop definition critical factors precision positioning represents key issue final system performance article discusses error budget methodology advantageous technique improve measurement accuracy long range stage design phase nanopositioning platform nanopla presented specifications travel range sub micrometric accuracy novel designed solutions three layer two stage architecture described defined prototype error analysis performed propose improvement design features metrology loop system mathematically modelled define propagation different sources several simplifications design hypothesis justified validated including assumption rigid body behavior demonstrated finite element analysis verification different error sources estimated contributions enumerated order conclude final error values obtained error budget measurement deviations obtained demonstrate important influence working environmental conditions flatness error plane mirror reflectors accurate manufacture assembly components forming metrological loop thus temperature control degrees results acceptable maximum positioning error developed nanopla stage axis respectively
early diagnosis breast cancer crucial successful treatment recovery phases patients suffering disease although mammography considered gold standard diagnosis fails detect cancers high density breasts work propose first time tridimensional biosensor platform used electrochemical point care device bioconjugated platform constructed series covalent linkages lectin molecules cysteine layer immobilized gold coated tio butterfly like tridimensional nanomembranes use vegetal lectins managed take advantage markedly atypical glycomic profile cancerous mammalian cell membrane successfully made distinction highly invasive less invasive mcf cancer cell lines selectivity biosensor tested using normal human skin fibroblast proposed cytosensor demonstrated limits detection low cells every cell line linear range cells considering electrochemical impedance values correlated number breast cancer cells present sample suggest proposed platform could useful facilitating diagnosis cancer
predictions different magnetic core losses acceptable accuracy key parameters temperature rise calculations considered rate large hydro electrical machines common practice hydro electrical designers compute core losses different section machine function flux density given manufacturer steel lamination probably leads inaccurate prediction magnetic core losses paper certain currently available core loss models used compute electromagnetic core losses large hydro electrical machine obtained results discussed compared available test data
sintered dicalcium pyrophosphate sdcp synthetic pyrophosphate analog shown potential management osteoporosis long term oral toxicity anti osteoporotic effect sdcp postmenopausal osteoporosis rat model evaluated study sdcp orally administered bilateral ovariectomized ovx wistar rats dose daily weeks following weeks observation abnormal findings clinical signs toxicity food consumption body weight blood examination necropsy histological inspection attributable ingestion sdcp serum level type collagen fragments bone resorption marker decreased sdcp treated rats bone formation markers alkaline phosphatase osteocalcin osteopontin significantly decreased findings indicate bone turnover rate decreased sdcp treated animals relative ovx rats increase serum tartrate resistant acid phosphatase level represents increase bony tissues sdcp treated rats histological examinations distal femoral metaphyses revealed ingestion sdcp improved trabecular bone architecture decreased bone porosity analysis limb bone ashes showed significant increase bone mineral content results show sdcp inhibits bone resorption restore bone mass ovx rats without deleterious effects therefore sdcp potential management osteoporosis
cloud fog dew computing concepts offer elastic resources serve scalable services resources scaled horizontally vertically former powerful increases number machines scaled retain performance service however scaling tightly connected existence balancer front scaled resources balance load among end points paper present successful implementation scalable low level load balancer implemented network layer scalability tested series experiments small scale servers providing services range dew computing services experiments showed adds small latency several milliseconds thus slightly reduces performance distributed system underutilized however results show balancer achieves even super linear speedup speedup greater number scaled resources greater load paper discusses also many benefits balancer provides
background selection representative mass profiles rheumatoid arthritis serum samples developed allows selection identification potential biomarkers serum samples methods controls samples analyzed using maldi tof two different protein elution procedures utilizing ziptips examined statistical evaluation data performed using different feature selection methods combination different classifiers identification selected masses performed using maldi tof tof results utilization proposed statistical strategy allowed selection different masses according method elution procedure obtained masses subjected targeted identification panel proteins identified potential markers role proteins discussed relation pathomechanism conclusion application advanced biostatistical analysis obtained maldi tof datasets resulted targeted selection potential biomarkers five proteins identified due procedure six proteins identified due procedure respectively panel identified proteins suggest presented statistical methodology proteomic strategy correct gave valid results obtained results may contribute development clinically useful multicomponent diagnostic tool elsevier inc rights reserved
compared computer aided design cad use computer graphics technologies describe geometric information product design many new methodologies systems developed past decades product modeling extend functions traditional cad systems product representation aspect addition design solution usually modeled geometric descriptions modeling product knowledge widely investigated describe rationale creation product solution information technology aspect addition traditional computing tools computer programming languages object oriented design distributed computing technologies particularly internet web cloud computing tools widely employed implement product modeling systems product development process aspect addition design solution product lifecycle aspects manufacturing maintenance service modeled integrated environment literature review recent advances research product modeling product representation information technologies product development process investigated three new perspectives knowledge distributed computing product lifecycle addition traditional methodologies future challenges computer based product modeling also discussed elsevier rights reserved
recently wei propose sharing digital image scheme sdis shares color secret image two shadow images based boolean exclusive operation three types shadow images wei sdis noise like black white meaningful color meaningful shadow images however exist wealmesses wei sdis incorrect assignment color palette data color index erroneous recovery secret image partial region shadow image revealing cover image paper solve weaknesses propose new sdis experimental results demonstrate scheme effectively avoids weaknesses
background research shown suicide phenomenon highly present among drug dependent population different studies demonstrated upraised level comorbidity personality disorders substance use disorders sud study aimed describe pds frequent among patients risk suicide methods study based consecutive non probabilistic convenience sample bereaved patients attended public addiction center girona spain sociodemographic data well suicide drug related characteristics recorded risk suicide assessed spanish version risk suicide personality disorders measured spanish version millon multiaxial clinical inventory results pds associated presence risk suicide depressive avoidant schizotypal borderline disorders however histrionic narcissistic compulsive pds inversely associated risk suicide even though narcissistic scale statistical correlation conclusions risk suicide significant factor take account related patients sud especially presence specific pds findings underline importance diagnosing treating rigorously patients sud
geothermal systems becoming increasingly popular surge green building however popularity limited lack knowledge perceived risk associated new system systems pollute environment operate earth natural energy alter chemical compounds geothermal systems cheaper long run equipment uses combustion requires expensive fuel operate savings counteract higher price equipment installation energy conservation also benefits society less damage environment buildings sustainable recognized leed certification properties violate environmental standards penalized geothermal systems good option improve sustainability improve quality work environment profitability business moderately sized retail building projects use advantage compared paper provides depth study geothermal system retails stores northeastern united states
mona lisa effect describes phenomenon eyes portrait appear look observer regardless observer position recently metaphor cone gaze proposed describe range gaze directions within person feels looked width gaze cone five degrees visual angle either side given gaze direction used functional magnetic resonance imaging investigate brain regions involved gaze direction discrimination would differ centered decentered presentation positions portrait exhibiting eye contact subjects observed given portrait eyes presenting portraits varying gaze directionseye contact degrees gaze edge gaze cone degrees clearly averted gaze degrees revealed brain response gaze edge gaze cone similar produced eye contact different produced averted gaze right fusiform gyrus right superior temporal sulcus showed stronger activation gaze averted compared eye contact gaze sensitive areas however affected portrait presentation location sum although brain clearly distinguishes averted centered gaze substantial change vantage point alter neural activity thus providing possible explanation feeling eye contact upheld even decentered stimulus positions hum brain mapp wiley periodicals inc
distal radius fracture wrist one common fractures children adults especially women causes different children mainly due sports injuries latter primarily related disorders including elderly osteoporosis aim work review distal radial fracture elements history different types classifications updated aspects management patients injury included including use external fixators authors address issue extensive literature review images figures taken literature made authors
gravel bed biala river polish carpathians heavily affected channelization channel incision twentieth century impacts detrimental ecological state river also adversely modified conditions floodwater retention flood wave passage therefore years ago erodible corridor delimited two sections biala enable restoration river sections short channelized reaches located vicinity bridges alternate longer unmanaged channel reaches either avoided channelization channel widened channelization scheme ceased maintained effects alternating channel morphologies conditions flood flows investigated study pairs neighbouring river cross sections constrained freely developed morphology discharges particular recurrence intervals determined cross section using empirical formula morphology cross sections together data channel slope roughness particular parts cross sections used input data hydraulic modelling performed one dimensional steady flow hec ras software results indicated freely developed cross sections usually multithread morphology typified significantly lower water depth larger width cross sectional flow area particular discharges single thread channelized cross sections also exhibit significantly lower average flow velocity unit stream power bed shear stress pattern differences hydraulic parameters flood flows apparent two types river cross sections varies discharges different frequency contrasts hydraulic parameters unmanaged channelized cross sections pronounced low frequency high magnitude floods however deep incision river cross section types typified similar low potential retention floodwater floodplain areas study indicated even though river restoration begun already brings beneficial effects flood risk management reducing flow energy shear forces exerted bed banks channel unmanaged river reaches within wide unmanaged channel reaches flows low frequency high magnitude floods conveyed relatively low shear forces exerted channel boundary contrast channelized reaches flow velocity shear forces substantially higher inevitably causing bank erosion channel incision elsevier rights reserved
analog layout generation advanced cmos design challenging increasing layout constraints performance requirements situation becomes intricate growing parasitic variability manufacturing reliability facilitate feasibility template based layout migration paper first introduces layout preservation extracts placement routing behaviors existing layout crossing graph via constrained delaunay triangulation later crossing graph migrated multiple layouts placement routing reconnection proposed approach also provides refinement wire optimize performance metrics approach applied variable gain amplifier folded cascode operational amplifier low dropout regulator experimental results demonstrate possibility layout migration averagely routing migrated layout generated approach additionally exhibits productivity qualified performance different designs
visual cryptography many shares generated illogical containing certain message within shares piled jointly tend expose secret image notion visual secret sharing scheme encrypt secret image illogical share images unable reveal data original image least one shares achieved original image fact realized overlapping entire shares directly order human visual system competent identify collective secret image without employing complicated computational tools therefore communicated steadily number shares elliptic curve cryptography approach turn employed augment privacy safety image new fangled technique utilized generate multiple shares subjected encryption decryption means elliptic curve cryptography technique test outcomes revealed fact peak signal noise ratio mean square error value correlation coefficient decrypted image without sort distortion original image
higher level cognition depends ability learn models world characterize computational level structure learning problem goal best identifying prevailing causal relationships among set relata however computational cost performing exact bayesian inference causal models grows rapidly number relata increases implies cognitive processes underlying causal learning must substantially approximate powerful class approximations focuses sequential absorption successive inputs captured neurath ship metaphor philosophy science theory change cast stochastic gradual process shaped much people limited willingness abandon current theory considering alternatives ground truth hope approach inspired metaphor algorithms approximating bayesian inference machine learning propose algorithmic level model causal structure learning learners represent single global hypothesis update locally gather evidence propose related scheme understanding limitations learners choose informative interventions manipulate causal system help elucidate workings find support approach analysis experiments
lightweight aggregates used civil engineering market sintered high temperature degrees times high energy prices regulation carbon dioxide emissions lightweight aggregate products high temperature process sales marketing readily accepted study developed sintered type paper sludge lightweight aggregate order reduce energy consumption substitution reservoir sediment clay paper sludge substitutes expected study used two types paper sludge green clay paper sludge paper pulp sludge sintering temperature reduced effectively green clay paper sludge substituted reservoir sediment clay optimum substitute ranges green clay paper sludge optimum substitute ranges paper pulp sludge test results show properties aggregates particle density water absorption loss ignition loss ignition aggregate became greater increase paper sludge content means calorific value provided paper sludge increase paper sludge content increases paper sludge therefore considered good material provide heat energy sintering lightweight aggregate
ambient assisted living aal technologies provide assistance support persons dementia might allow possibility living home longer whilst maintaining comfort security well offering way towards reducing huge economic personal costs forecast incidence dementia increases worldwide coming decades however development introduction use aal technologies also trigger serious ethical issues paper systematic literature review going scholarly debate issues specifically look ethical issues involved research development clinical experimentation clinical application aal technologies people dementia related stakeholders discussion focus value goals aal technologies special vulnerability persons dementia private homes complex question informed consent usage aal technologies
mercury discharge lamp technology basis fluorescent lighting lamps water purification showed modifying ratios seven stable isotopes mercury natural relative abundances lamp efficiencies improved parallel recent methods isotope separation make cost optimized isotopic mixtures economically competitive review recent developments discuss implications future lighting lamp technologies
piezoresponse force microscopy pfm probes mechanical deformation sample response electric field applied tip atomic force microscope originally developed two decades ago study ferroelectric materials technique since used probe electromechanical functionality wide range piezoelectric materials including organic biological systems piezoresponse force microscopy also demonstrated useful tool detect mechanical strain originating electrical phenomena non piezoelectric materials parallelling advances analytical numerical modelling many technical improvements made last decade switching spectroscopy pfm allows polarisation switching properties ferroelectrics resolved real space nanometric resolution dual resonance tracking band excitation pfm used improve signal noise ratio turn advances led increasingly large multidimensional data sets containing complete information properties sample studied review pfm operation calibration described recent advances characterisation electromechanical coupling using pfm presented breadth systems covered highlights versatility wide applicability pfm fields diverse materials engineering nanomedicine fields combining pfm complementary techniques key develop future insight intrinsic properties materials well device applications
traditional missile guidance law difficult adapt complex operational environment variable structure control advantages fast response insensitive parameter variation disturbance none line identification system simple physical realization paper take medium range air air missile fire control research object make use sliding mode variable structure control algorithm establish medium range air air missile variable structure guidance law calculate change rates expected value result dynamic model kinematic model missile combined variable structure guidance model formed
purpose paper develop constructive versions stafford theorems module structure weyl algebras rings partial differential operators polynomial coefficients base field characteristic zero generally based results stafford coutinho holland develop constructive versions stafford theorems simple domains algorithmization based fact certain inhomogeneous quadratic equations admit solutions simple domain show explicitly compute unimodular element finitely generated left module rank least two result used constructively decompose finitely generated left module direct sum free left module left module rank one latter torsion free explicitly show isomorphic left ideal generated two elements give algorithm reduces number generators finitely presented left module module relations rank least two particular finitely generated torsion left module generated two elements homomorphic image projective ideal whose construction explicitly given moreover non torsion non free left module rank generated elements fewer results implemented stafford package system theoretical interpretations given within module approach finally prove results also hold ring ordinary differential operators either formal power series locally convergent power series coefficients using result caro levcovitz also ring partial differential operators coefficients field fractions ring formal power series ring locally convergent power series
introduction previous work authors reported findings years incidence hematological malignancies szabolcs szatmar bereg county hungary studies topic available hungary aim detailed analysis epidemiologic features patients philadelphia negative chronic myeloproliferative disorders carried method year period january december adult patients hematologic malignancies recorded leukaemia lymphoma registry szabolcs szatmar bereg county among patients polycytaemia vera primary myelofibrosis essential thrombocytaemia registered results incidence polycythaemia vera essential thrombocythaemia szabolcs szatmar bereg county showed increasing tendency overall incidence rate inhabitants year respectively incidence primary myelofibrosis decreased course years inhabitants year cases polycythaemia vera primary myelofibrosis male female ratio found equal however essential thrombocythaemia showed female dominance mean age patients polycythaemia vera years similar essential thrombocythaemia years primary myelofibrosis years two villages found county occurrence patients philadelphia negative chronic myeloproliferative disorders per one thousand inhabitants significantly higher average every familial cases manifestation disease second third generations became earlier first genetration perceived average degree anteposition anticipation found years conclusion epidemiologic features philadelphia negative chronic myeloproliferative disorders szabolcs szatmar bereg county essentially similar data published literature
background dementia care practitioner training essential professional caregivers acquire medical knowledge care skills dementia patients investigated significance training stress management evaluating caregivers job stress coping style completed training methods subjects included professional caregivers men women recruited participants training programmes held kanagawa prefecture august march survey using brief job stress questionnaire coping scale carried completed training test multiple regression analysis performed evaluate effects training result training scores modifiers job stress scale coping scale increased whereas scores stress reactions job stress scale decreased however changes participants subjective cognition concerning workplace environment furthermore change stress reaction score tended correlate change consultation score participants change problem solving consultation male participants among female participants change stress reaction score tended correlate change support superiors colleagues modifiers factors correlated change stress reaction score differed genders conclusion findings suggest training caregivers improves stress reaction coping skills
plasma testosterone levels display circadian variation peaking sleep reaching nadir late afternoon superimposed ultradian rhythm pulses every min reflecting underlying rhythm pulsatile luteinizing hormone secretion increase testosterone sleep rather circadian rhythm dependent requires least sleep normal architecture various disorders sleep including abnormalities sleep quality duration circadian rhythm disruption sleep disordered breathing may result reduction testosterone levels evidence support direct effect sleep restriction circadian rhythm disruption testosterone independent effect sex hormone binding globulin shbg presence comorbid conditions equivocal balance seems tenuous obstructive sleep apnea osa appears direct effect testosterone adjusting age obesity however possible indirect causal process may exist mediated effect osa obesity treatment moderate severe osa continuous positive airway pressure cpap reliably increase testosterone levels studies contrast reduction weight predictably linearly proportion amount weight lost apart transient deleterious effect testosterone treatment adversely affect osa data effect sleep quality testosterone may depend whether testosterone given replacement supratherapeutic doses context abuse experimental data suggest testosterone may modulate individual vulnerability subjective symptoms sleep restriction low testosterone may affect overall sleep quality improved replacement doses large doses exogenous testosterone anabolic androgenic steroid abuse associated abnormalities sleep duration architecture
article deals intelligent systems contain artificial neural networks close comparison artificial biological neural networks authors reveal fundamental flaws artificial neural networks shown reason disadvantages constancy structure called passivity neural network avoid problem proposed simulate information processes neural network instead simulating neurons following consideration involves several evolutionary principles multi alternativity multilevel approach diversity modularity principles find implementation facet memory organization characterized reconfigurable structure therefore close biological prototype advantage suggested approach demonstrated example intellectual system based active neural network system applied control electrical supply network critical events breaks overloads case critical event neural network takes blocking decision prevents breakage accident conditions electrical network authors published elsevier
background psoriasis complex heterogeneous disease resulting interactions genetic immunological environmental factors make optimal treatment decision dermatologist must therefore detailed overview patient history lifestyle objectives sought offer overview various relevant aspects clinical dermatological assessment psoriasis patients emphasizing importance multidisciplinary integrated clinical approach methods gathered information psoriasis management developed tailored checklist covering health related aspects associated psoriasis results demographics personal family history elaborately described well drug history discuss affect psoriasis management relevant patient information vaccination status cardiovascular profile included checklist well treatment recommendations adapted updated accordance evidence based literature checklist also emphasizes importance drug surveillance proper follow specialist referral dermatologist needs address health related aspects assessing psoriasis patients going beyond optimal skin care conclusions comprehensive overview used consultation checklist good clinical practice psoriasis patient management aid treatment decision
paper presents first method enables fully automatic generation triangular meshes suitable called non uniform rational spline nurbs enhanced finite element method nefem meshes generated proposed approach account computer aided design boundary representation domain given nurbs curves characteristic element size completely independent geometric complexity presence small geometric features proposed strategy allows circumvent time consuming process featuring complex geometric models finite element mesh suitable analysis produced generalisation original definition nefem element also proposed enabling treat complicated elements edge defined several nurbs curves one edge defined different nurbs three examples increasing difficulty demonstrate applicability proposed approach illustrate advantages compared traditional finite element mesh generators finally simulation electromagnetic scattering problem considered show applicability generated meshes finite element analysis authors international journal numerical methods engineering published john wiley sons ltd
today managing data critical kind users users use cloud database services managing data time security reasons want keep crucial private data end face problem like integrate kind data one located local rdbms cloud repositories paper analyzed hadoop used solve kind problems hadoop platform used integrate data one located cloud databases located local rdbms hadoop components process huge amount data help inbuilt security mechanisms one also securely store data
commentary first analyze elson ferguson attempt offer theory would explain exposure family community school media violence could related increased aggression cause aggression conclude new theory offer new differs dominant social learning theories claim relation exposure violence aggression almost entirely due people genetically biologically predisposed aggressive also exposing violence show assertion strongly contradicted existing experimental longitudinal data also show elson ferguson called exhaustive review empirical data topic seriously flawed claim effect sizes trivial supported math claim scholars believe violent video games cause aggression extreme group divided field contradicted surveys show vast majority researchers believe violent video games increase aggression point claim scholars believe media violence effects moral panic theoretical empirical support whereas contrasting argument researchers produce violent media use extensively biased force cognitive consistency experience reactance regulatory panic support psychological theory
multicultural society germany also impact healthcare system regardless country origin denomination migrants entitled high quality emergency medical care equal access facilities services german healthcare system literature review evaluation results care foreign patients necessary emergency physician aware potential sources miscommunication causes misunderstandings often due verbal communication however misunderstandings start earlier also relate nonverbal communication misunderstandings rescue personnel interact foreign patients found verbal level two forms insufficient language skills insufficient knowledge called organ metaphors prevent understanding content message language barriers communicating foreign patients present three alternatives communication via universal language english communication interpreter use visual communication aids verbal communication restricted possible nonverbal communication usually help culturally sensitive care achieved subject intercultural competence increasingly implemented education training develop culturally sensitive patient care change development processes required several levels must involve parties concerned
emergency contraception safe effective method used prevent unwanted pregnancy unprotected sexual intercourse many unwanted pregnancies end unsafe abortions search ideal contraceptive interfere spontaneity pleasure sexual act yet effectively controls fertility still continuing numerous contraceptive techniques available yet contraceptive coverage continues poor india thus even planning pregnancy exposure unprotected sex takes place often necessitating use emergency contraception need may also arise due failure contraceptive method used condom rupture diaphragm slippage forgotten oral pills following sexual assault emergency contraception intervention prevent large number unwanted pregnancies resulting failure regular contraception unplanned sexual activity turn helps reducing maternal mortality morbidity due unsafe abortions however concern expressed regarding repeated indiscriminate usage pill currently rational use emergency contraception promoted expected make significant dent reducing number unwanted pregnancies unsafe abortions fact since introduction emergency contraception contribution unsafe abortion towards maternal mortality declined per cent
previous research exploring cognitive biases bulimia nervosa suggests attentional biases occur food related body related cues individuals bulimia compared non bulimic controls emotional stroop task contained food related body related cues results indicated bulimics controls demonstrated cognitive bias food related body related cues however discrepancy two cue types observed body related cognitive biases showing robust effects food related cognitive biases strongly associated severity disorder results may implications clinical practice bulimics increased cognitive bias food related cues indicated increased bulimic disorder severity elsevier ltd rights reserved
background dementia lewy bodies dlb second frequent diagnosis progressive degenerative dementia older people delusions common features dlb among capgras syndrome represents frequent disturbance characterized recurrent transient belief familiar person often close family member caregiver replaced identical looking imposter however delusional conditions near misidentification syndromes occur dlb patients may represent major psychiatric disorder although rarely studied systematically case presentation reported female patient affected dlb presented unusual delusion duplication referring female professional caregiver engaged relatives care patient constantly described presence two different female persons disorder framed context delusion duplication brain hexamethylpropyleneamineoxime spect performed showing moderate hypoperfusion occipital lobes associated marked decreased perfusion parieto fronto temporal lobes bilaterally conclusions occipital hypoperfusion identified although association marked global decrease perfusion remaining lobes role posterior lobes certainly important misidentification syndromes natural dissociation recognition identification present moreover concomitant presence severe attentional executive deficits evocative frontal syndrome marked global decrease perfusion remaining lobes spect scan also suggest possible dysfunction abnormal connectivity anterior posterior areas
background adolescent behaviour strongly linked emotions aim study analyse differences young offenders non offenders emotional instability anger aggressive behaviour anxiety depression also differences according sex compare relation emotional instability anxiety depression aggressive behaviour mediated modulated anger groups method participants adolescents male female years old young offenders four different correctional centres valencia region participants randomly chosen ten public private schools valencia metropolitan area schools instruments applied collectively classroom minutes maximum duration youth detention centre application carried small groups results structural equation model sem carried group young offenders non offenders show relation assessed variables emotional instability appears strongly related anger samples anger predicts depression aggressive behaviour offender population conclusions results give relevant information treatment prevention aggressive behaviour delinquency teenagers emotional regulation
objective cognitive constructivist psychotherapy approach considers self continuous regulation process present past experience attributions meaning characterized use internal rules conception everyone would driven specific inner coherence called personal meaning organization pmo approach never applied neurological patients means hoc developed tools performed explorative study aimed characterize personality styles different neurological conditions within theoretical framework cognitive constructivist model materials methods three groups neurological patients amyotrophic lateral sclerosis multiple sclerosis primary headache sample healthy participants composed participants total participants recruited personal meaning questionnaire pmq italian questionnaire assessing pmos construct clinical tools psychological quality life assessment administered subjects results main finding concerned detection across clinical conditions higher prevalence phobic personality style amyotrophic lateral sclerosis showing relevant prevalence pmo respect neurological conditions controls however respect controls clinical conditions pmq highlighted tendency even statistically significant codify experience means specific cognitive emotional patterns conclusion findings represent first contribution towards understanding personality profiles patients affected neurological conditions according cognitive constructivist theory
background antioxidant hypothesis regarding risk asthma childhood resulted inconsistent findings data indicate role antioxidants childhood asthma risk may critical time window effect well designed longitudinal cohort study clarify hypothesis objective study longitudinal associations serum carotenoid tocopherol concentrations first years life asthma risk age years methods based case control design nested within finnish birth cohort asthma cases matched controls birth time sex genetic risk birth place non fasting blood samples collected ages years serum carotenoids tocopherols analysed parents reported presence age start persistent doctor diagnosed asthma child age years data analyses conducted using generalized estimating equations results find strong associations serum carotenoids tocopherols risk asthma based age specific longitudinal analyses lower higher quarters alpha carotene gamma tocopherol increased risk asthma conclusions current findings support suggestion increased prevalence asthma may consequence decreased intake antioxidant nutrients moreover confirm critical time window impact antioxidants asthma risk replication findings similar longitudinal settings strengthen evidence base
objectives evaluate partial remission treatment infliximab ifx naproxen npx npx alone patients two subgroups spa explore baseline predictors partial remission methods infliximab first line therapy patients early active axial spondyloarthritis trial double blind randomised controlled trial ifx biologic patients early active axial spa patients randomised receive weeks treatment ifx weeks npx day placebo pbo npx day current post hoc analysis evaluated outcomes patients meet modified new york radiographic criteria results analysis included patients met criteria non radiographic axial spa axspa week assessment spondyloarthritis international society asas partial remission greater ifx npx pbo npx group respectively axspa group respectively similar pattern occurred several efficacy measures larger treatment effects occurred group axspa group possibly due baseline differences disease characteristics multivariable analyses identified type treatment age hla status predictors asas partial remission total study population mri sacroiliac joint scores associated partial remission ifx npx treatment conclusion patients greater partial remission ifx nsaid nsaid therapy alone patients axspa smaller treatment effect baseline disease characteristics age associated partial remission ifx therapy
alkali activated cementitious materials prepared naoh sodium silicate alkali activator alkali slag slag powder lime raw material effect amount alkali slag activator catalog compression strength material investigated results showed naoh stimulating effect sodium silicate stimulating effect naoh sodium silicate stimulating effect mixture alkali slag slag powder excitation intensity different different age strength material increased content slag powder increasing naoh used activator strength materials reached maximum alkali slag powder certain proportion sodium silicate used activator
mucor ubiquitous fungus belongs family zygomycetes though noninvasive saprophyte normal host cause life threatening infections immunocompromised patients including angioinvasive pulmonary mucormycosis disease notorious high mortality article tracks ever changing management pulmonary mucormycosis last years affected mortality
damping devices involving piezoelectric elements single piezoelectric patch consistently achieve multimodal control charge cancellation vibration node location order sense control structural vibration prescribed frequency range solution consists using array several piezoelectric patches small compared smallest wavelength control extension tuned mass damper strategy passive multimodal control requires implement damping system whose modes close possible controlled structure way electrical equivalent discretized mechanical structure represents passive network optimizes energy transfer two media onedimensional structures periodic distribution several unit cells enables use transfer matrix method applied electromechanical state vectors optimal passive networks obtained propagation longitudinal transverse waves numerical implementation coupled behavior performed compared classical resonant shunts network topology induces promising multimodal damping reduction needed inductance thus possible create completely passive electrical structure demonstrated experimentally using purely passive components
additional design consideration plug hybrid electric vehicle phev caused recharging capability requires optimal hybrid powertrain control strategy fully exploit vehicle capability amongst many aspects control algorithm development design optimisation advantage including pure electric vehicle mode vehicle driving modes phev post transmission electric motor studied research purpose architecture series parallel phev determined simulation model developed various simulations conducted evaluate technical merits pure mode terms fuel economy emissions simulation results favourably supports inclusion pure mode one driving modes powertrain control strategy studied phev model post transmission electric motor
fly ash recognized hazardous material causing air soil water pollution fly ash waste product electricity generation power plants coal based thermal estimated annual production approximately two hundred million tons spite many problems associated like land requirement disposal toxicity groundwater handling issues etc started treating fly ash resource material present research addresses usage fly ash roads bridges embankments present study attempt made recognize analyze comprehensively key elements sub elements program implementation fly ash usage segregate critical factors cfs usage fly ash roads bridges embankments eight relevant cfs recognized usage fly ash roads bridges ten cfs usage fly ash embankments thereafter interpretive structural modeling ism approach applied cfs two models driver cfs linkage cfs driven cfs obtained appropriate discussions along micmac analysis light important elements sub elements helped present managerial implications useful stakeholders elsevier ltd rights reserved
experimental technique based time averaged circular geometric moire optical measurement angular oscillations presented paper pitch circular moire preselected way angular oscillations different amplitudes yield time averaged moire fringes different locations cover image optical effect enables construct optical scale direct measurement angular oscillations proposed technique similar visual cryptography cryptographic technique allows encryption visual information way decryption done without use computational device efficiency applicability proposed technique performance degradation prediction rotating mechanical components illustrated validated computational simulations experimental tests
nitrate cycling essential sustaining soil systems excessive application fertilizers associated underground water contamination attracted great deal research attention sorption efficient environmentally friendly nitrate fixation debate noted literature regarding whether biochars potential fix nitrate sorption study biochars produced different biomasses well biomass compositions chosen absorbents evaluate potential efficiencies nitrate fixation increased sorption nitrate observed biochars increased pyrolysis temperature increasing extent varied biomass surface base functional groups surface charges biochars could well explain nitrate sorption significant positive correlation nitrate sorption biochar surface areas suggested surface area controlling parameter nitrate sorption pre coating tannic acid biochars decreased completely inhibit nitrate sorption observation suggested nitrate sorption biochars may decreased interactions natural organic matter nitrate sorption compared among various adsorbents including biochars soil particles clay minerals engineered particles well humic substances soil particles generally showed high sorption nitrate biochars result suggested biochars investigated work may play limited role nitrate fixation sorption massive application nitrogen fixation nitrate adsorption biochars carefully evaluated taking consideration biochar feedstocks properties elsevier rights reserved
essay examine expos realities regarding poverty immorality sexual crime irish free state radical journal honesty honesty edited socialist republican james upton man longstanding commitment rights women poor upton instinct anti establishment era country religio political leadership insecure keen manage free state news agenda something attempted service projecting viewed ideologically acceptable image life free sate domestic foreign audiences upton viewed policy manifestation social political cant favoured free state leadership aided abetted gave succour hypocrisy wider bourgeois free state society coalition forces upton reasoned damaged interests vulnerable sections irish society particular nation women children living breadline however notwithstanding radicalism reputation free state honesty largely lost history irish journalism
hybrid microgrids expected play important role expansion access electricity developing countries systems operated dispatch strategies make use predictions load availability renewable energy resources forecast based strategies recently gained attention alternative bring operation costs work develop framework assess potential range assumptions quality load photovoltaic generation forecasts application methodology village households reveals cost savings ranging depending forecast quality composition microgrid also show sizing microgrid components assumption predictive operation strategy results design higher share intermittent generation elsevier ltd rights reserved
self consolidating concrete scc concrete material possessing ability take formwork shapes pass congested reinforcement bars without vibrated making smart concrete material however high cost scc resulting use mineral fillers high cement content main factor impeding widespread use smart material consequently need investigate use low cost materials production scc ensure adoptability scc concrete construction paper presents results study conducted develop evaluate performance four scc mixtures using different combinations filler materials silica fume natural pozzolana metakaolin conjunction limestone powder developed scc mixtures exhibited high strength compressive tensile bond elastic modulus excellent shrinkage behavior good durability characteristics high corrosion resistance related indices findings study indicated possibility producing cost effective high performance scc mixtures using mineral fillers considered study elsevier ltd rights reserved
purpose study examine effects auricular acupressure smoking cessation male college students experimental group received auricular acupressure specific acupoints smoking cessation whereas control group received sham auricular acupressure nonspecific acupoints participants received weeks auricular acupressure intervention experimental group auricular acupressure applied shenmen lung subcortex hunger stomach mouth data nicotine dependence self efficacy smoking cessation exhaled carbon monoxide collected group times intervention weeks intervention weeks intervention statistical differences two groups pretest posttest emerged self efficacy smoking cessation exhaled carbon monoxide nicotine dependence
mapreduce algorithm described mapping schema assigns inputs set reducers required output exists reducer receives inputs participating computation output reducers capacity limits sets inputs assigned however individual inputs may vary terms size consider first time mapping schemas input sizes part considerations restrictions one significant parameters optimize mapreduce job communication cost map reduce phases communication cost optimized minimizing number copies inputs sent reducers communication cost closely related number reducers constrained capacity used accommodate appropriately inputs requirement inputs must meet reducer satisfied work consider family problems required input meets input least one reducer also consider slightly different family problems input list required meet input another list least one reducer prove finding optimal mapping schema families problems hard present bin packing based approximation algorithm finding near optimal mapping schema
herein techno economic assessment performed energy crop based biogas plant coupled greenhouse utilizing thermal energy produced cogeneration seven energy crops evaluated triticale maize alfalfa sunflower clover barley wheat according evaluation triticale competitive energy crop selected climate conditions northern greece although maize displays higher biomass yield biogas potential drought resistant crop triticale high irrigation demand contributes significantly total production costs triticale based biogas production become economically feasible agricultural arable area larger biogas plant size larger required however public funding biogas production becomes feasible smaller area biogas plant size inclusion greenhouse design biogas plant contributes positively economic viability entire system scenario greenhouse financial income accounts total income results sensitivity analysis suggest selection appropriate energy crop biogas production based principally digestibility specific methane yield biomass yield per hectare factors critical biomass production costs
gestures commonly used together spoken language human communication one major limitation gesture investigations existing literature lies fact coding forms functions gestures clearly differentiated paper first described recently developed database speech gesture based independent annotation gesture forms functions among neurologically unimpaired right handed native speakers cantonese divided three age two education levels presented findings investigation examining gesture use related age linguistic performance consideration two factors normative data currently limited lacking literature relevant necessary one evaluates gesture employment among individuals without language impairment three speech tasks including monologue personally important event sequential description story telling used elicitation eudico linguistic annotator software used independently annotate participant linguistic information transcript forms gestures used function gesture one third subjects use verbal gestures majority gestures non content carrying functioned mainly reinforcing speech intonation controlling speech flow content carrying ones used enhance speech content furthermore individuals younger linguistically proficient tended use fewer gestures suggesting normal speakers gesture differently function age linguistic performance
silicon process geometry reduced scale growing electronic design automation eda industry underlying circuitry chip become complex cost designing complex systems drives towards path employing automation field analog circuit design paper heuristic based river formation dynamics rfd presented design analog circuits user defined specifications search strategy rfd scheme employed advance stringent design requirements evaluate optimum solution two stage cmos operational amplifier circuit experimental results show competent performance rfd scheme terms quality solution compared standard optimization techniques
background atopic dermatitis eczema inflammatory skin disease associated significant impairment quality life important objectively quantify cutaneous biophysical measurements research therapeutics disease objective evaluate skin redness erythema pigmentation melanin correlate disease severity quality life methods redness pigmentation measured standardized condition antecubital flexure nottingham eczema severity score ness children dermatology life quality index cdlqi documented results pigmentation correlated age disease severity ness quality life cdlqi erythema correlated age ness pigmentation cdlqi trend conclusions skin erythema pigmentation increase age erythema correlates disease severity pigmentation correlates neither severity quality life score objective measurement two signs replace clinical measurements severity quality life may limited scope eczema research therapeutics
hospital readmission lung transplantation negatively affects quality life resource utilization secondary analysis data collected prospectively conducted identify pattern incidence count cumulative duration reasons predictors readmission lung transplant recipients ltrs assessed discharge majority ltrs readmitted multiple readmissions median cumulative readmission duration days main reasons readmission infection rejection infection rejection infection rejection ltrs required reintubation odds ratio discharged care facilities higher risk readmission cumulative incidence readmission thirty day readmission significantly predicted baseline characteristics predictors higher readmission count lower capacity engage self care incidence rate ratio irr discharge care facilities irr predictors longer cumulative readmission duration older age arithmetic mean ratio amr return intensive care unit amr lower capacity engage self care amr identifying ltrs risk may assist optimizing predischarge care discharge planning long term follow hospital readmission lung transplantation common primarily reasons infection rejection predicted reintubation initial posttransplant discharge care facilities poor engagement self care older age return icu perioperatively
people eye gaze forms nonverbal communication influence trust hypothesised similar effects would occur human robot interaction predicting humanoid robot eye gaze lifelike bodily movements eye tracking movements simulated breathing would increase participants likelihood seeking trusting robot opinion cooperative visual tracking task however instead found significant interactions robot gaze task difficulty indicating robot gaze positive impact upon trust difficult decisions negative impact easier decisions furthermore significant effect robot gaze found task performance gaze improving participants performance easy trials hindering performance difficult trials participants also responded significantly faster robot looked results suggest robot gaze exerts pressure upon participants causing audience effects similar social facilitation inhibition lifelike bodily movements significant effect upon participant behaviour
side population phenotype defined ability cell efflux fluorescent dyes hoechst common several stem progenitor cell types avian species phenotype identified pubertal adult testes nothing known expression prenatal development male gonad study characterized hoechst phenotype via cytofluorimetric analysis disaggregated testes different days chicken embryonic development male prenatal gonads contained fraction cells stage analyzed least two main fractions named identified percentage fraction decreased development proceeds whereas cell number affected gonad growth functional inhibition bcrp channel membrane using verapamil showed phenotype dependent bcrp activity molecular analysis sorted fractions revealed differential rna expression pattern indicating cells mainly contained germinal stem cell markers whereas preferentially composed sertoli leydig cell progenitor markers finally findings provided evidence phenotype common feature germ somatic cells detected chicken developing testis elsevier inc rights reserved
paper describes course developed authors university introduce first year engineering students fundamentals computer programming within context solving engineering problems two credit hour semester long course incorporates programming language matlab required course students major civil electrical mechanical engineering course usually taken second semester first year study designed utilize active learning techniques students complete series laboratory exercises projects introduce computer programming engineering applications paper describes origins course laboratory exercises projects course administered assessment successful course based student grades student feedback student survey results indicate course increased students knowledge programming context solving engineering problems
analyzed association proton pump inhibitors ppis mortality osteoporosis related hip fracture austria ppis associated reduced day mortality elevated mortality half year initiated pre fracture inpatients discharged patients ppis showed lowered hospital day mortality respectively herein investigated use proton pump inhibitors ppis mortality among hip fracture patients nationwide study austria retrospective cohort study data use ppis obtained austrian patients aeyen years hip fracture july december cause mortality patients without anti osteoporotic drug treatment received first recorded ppi prescription study period either fracture compared hip fracture patients neither ppis anti osteoporotic medication using logistic cox regression analysis ppi use day mortality significantly reduced initiation hip fracture day mortality also reduced ppis prescribed discharge last recorded hip fracture related hospital stay except patients aged years sub cohort patients beginning ppis hospital stay hospital mortality substantially reduced relative matched control patients longer term mortality significantly increased half year post fracture among started ppi prescription fracture ppi use hospital stay due hip fracture associated considerable decrease mortality findings could implications hip fracture treatment
recent economic events sparked debates degree structural mismatch economy one frequent claims workers lack skills employers demand existing literature however analyzes potential mismatch high level aggregation abstract indices noisy proxies obscure underlying mechanisms authors address issues presenting analyzing results survey manufacturing establishments survey first knowledge directly measure concrete employer skill demands hiring experiences nationally representative survey industry level findings indicate demand higher level skills generally modest three quarters manufacturing establishments show signs hiring difficulties among remainder demands higher level math reading skills significant predictors long term vacancies demands computer skills critical thinking problem solving skills particular interest high tech plants experience greater levels hiring challenges authors examine potential mechanisms could contribute hiring difficulties find neither external regional supply conditions internal firm practices predictive hiring problems rather data show establishments members clusters demand highly specialized skills greatest probability incurring long term vacancies authors interpret results sign important think factors complicate interaction supply demandsuch disaggregation communication coordination failuresrather simply focusing inadequate labor supply
background purpose receiving clear complete date information satisfying relationship health professional primary importance patients healthcare organization plays key role promoting effective relationship communication patients hps present study aims explore care organization service characteristics provided italian centres best predict patients satisfaction healthcare methods eighty one centres patients women mean age years mean education years time since diagnosis years included analysis care organization service provided centre evaluated comparison national institute health care excellence nice guidelines management patients satisfaction care measured using patient self assessed questionnaire comunicazione medico paziente nella sclerosi multipla revised section cosm section results clinical characteristics patients significantly affected satisfaction multivariate regression model showed higher patients satisfaction cosm score inversely associated hospital size number patients care beta confidence interval directly associated psychological interventions confidence interval conclusions multiple sclerosis patients larger hospitals less satisfied information received relationship hps building individualized relationship patients hps tailoring communication information improve patients satisfaction goal probably less likely accomplished larger centres many incoming patients moreover centres also provide structured psychological interventions patients satisfied
integrated information systems important safeguards utilisation development land resources information technologies including internet things iot cloud computing inevitable requirements quality efficiency land resources supervision tasks study economical highly efficient supervision system land resources established based iot cloud computing technologies novel online offline integrated system synchronised internal field data includes entire process discovering breaches analysing problems verifying fieldwork investigating cases constructed system integrates key technologies automatic extraction high precision information based remote sensing semantic ontology based technology excavate discriminate public sentiment internet related illegal incidents high performance parallel computing based mapreduce uniform storing compressing bitwise technology global positioning system data communication data synchronisation mode intelligent recognition four level device transfer system data safety control technology integrated system based one map platform officially implemented department land resources guizhou province china found significantly increase efficiency level land resources supervision system promoted overall development informatisation fields related land resource management
caused fungus fungal keratitis kind infections corneal disease high rate blindness patients mainly farmers developing contries interleukin important proinflammatory cytokines involve immune defense process fungal infection cornea expression interleukin pathogenesis fungal keratitis especially main source cells clear cell signaling pathways regulate synthesis modification interleukin still unknown caspase obtained cultured elisa western blot methods used explore regulatory effect caspse interleukin beta fungal keratitis neutrophils main cell lineage beta take part innate anti fungi immunity cornea beta generation induced fungal infection might pre excitation classical signal pathway tlr trif pathway involved pro beta generation dectin syk pathway involved beta generation fungal keratitis caspase participated modification beta change precursor mature body nlrp inflammasome asc inflammasome involved beta generation caspase involved beta generation regulating modified process caspase turning precursor mature body tlr trif pathway nlrp inflammasome asc inflammasome involved pro beta generation caspase caspase dectin syk pathway involved beta generation
synthetic aperture radar sar spaceborne tool allowing near real time imagery large ground footprints areas hundreds kilometres wide sar also allows persistent observations process oil discharges benefiting day night observations independence cloud cover high revisiting frequencies interpretation sar scenes lower congo basin period allowed recognition natural seepage slicks associated individual seep sites acquired additional sar data set short revisit time selected prolific area data set consisted sar scenes acquired day period meaning maximum revisiting period subsequent sar acquisitions short term approach shows seepage slicks detected wind speeds knots long term short term monitoring evidences seepage events intermittent occurrence rate oil release ranging short term monitoring shows seepage pace independent seep sites suggesting contrasted controlling factors also shows residence time seepage slicks systematically shorter far reported values understanding seepage slick residence time essential provide accurate estimation fluid flow compute volumetric outflow integration situ mooring points measuring current velocity sea surface addition local wind field slick length allowed accurately estimate residence time oil slicks sea surface vanishing results show sea surface residence time oil slicks limited hours median value min new residence time estimations allowed propose quantification regional oil output lower congo basin estimated year area may therefore considered world third biggest oil supplying province natural leakages elsevier inc rights reserved
survival advanced pancreatic cancer less months pancreatic exocrine insufficiency may contribute pancreatic cancer related cachexia via nutrient malabsorption aimed determine feasibility prescribing pancreatic extract creona patients advanced pancreatic cancer patients advanced pancreatic cancer without frank malabsorption randomised feasibility study pancreatic extract units meals units snacks placebo standardised dietary advice given anti cancer supportive care treatments permitted outcomes included weight body mass index bmi quality life qlqc pan survival nutritional assessment sga eighteen patients randomised study closure due slow recruitment baseline characteristics well matched weight loss prior randomisation numerically greater pancreatic extract group mean weight loss numerically greater placebo group however significantly differences bmi nutrition score seen quality life differ study groups median overall survival weeks control group weeks pancreatic extract group potentially eligible patients recruited related patient family reluctance rapid clinical deterioration patients already prescribed pancreatic extract moderate pill burden noted despite intriguing survival results study sufficiently feasible proceed fully powered comparative study multi centre study would required exclude significant difference outcomes
sigma delta modulator structure presented form matrix equations equations allow easily obtain analytical expressions noise signal transfer functions arbitrary modulator structures result modulator structures analysis comparison become straightforward
security traditional identity based signature ibs totally built upon assumption private key absolutely secure however increasing use mobile unprotected devices today cryptosystems threat key exposure represents serious realistic concern mitigate damage key exposure setting ibs propose integrate key evolution user revocation ibs present forward secure identity based signature user revocation ribs specifically formalize syntax security definition ribs give concrete construction proposed scheme proven secure standard model type complexity assumption demonstrate merits scheme theoretically analyse performance comparing related works moreover provide implementation corresponding timing results scheme show practicability
background research among people inject drugs pwids usa mexico identified range adverse health impacts associated policing pwids employed mixed methods design investigate pwids san diego mexico experienced policing tijuana interactions affect pwids behavior stratifying country origin methods pwids san diego used drugs mexico past six months enrolled stahr study qualitative interviews conducted subsample recently injected drugs mexico period pwids tijuana also enrolled cuete study qualitative interviews conducted subsample recently stopped police calculated descriptive statistics quantitative variables conducted thematic analysis qualitative transcripts integration data involved comparing frequencies across cohorts using qualitative themes explain explore findings results sixty one percent san diego based participants recently stopped law enforcement officers leos mexico reported somewhat likely would arrested mexico look like drug user ninety percent tijuana based participants recently stopped leos reported somewhat likely could get arrested look like drug user participants cohorts described bribery targeting leos mexico however san diego based participants described compliance bribery safeguard arrest detention mistreatment rare tijuana based participants described routinely targeted leos frequently detained reported instances sexual physical violence tijuana based participants described modifying injected drugs response experienced feelings stress anxiety powerlessness less common among san diego based participants mostly attempted avoid contact leos mexico engaging risky injection behavior conclusion experiences discrimination stigma reported larger proportion pwids living mexico suggesting may subject greater health harms related policing practices compared residing usa findings reinforce importance efforts curb abuse align policing practices public health goals mexico elsevier rights reserved
background aims methyl aspartate receptor nmdar brain spinal cord enteric nervous system involved visceral hypersensitivity study aimed reveal functional expression nmdar mucosal cells colon investigate downstream signal pathway colonic nmdar activation visceral hypersensitivity irritable bowel syndrome ibs methods expression mucosal nmdar ibs patients healthy controls assessed immunohistochemistry western blot correlated abdominal pain discomfort scores quantified validated questionnaire electromyography recording response colorectal distension recorded measure colonic sensitivity mice receiving nmda administration intracolonically brain derived neurotrophic factor bdnf expression extracellular signal regulated kinase erk pathway activation examined human colonic epithelial cells nmda stimulation without pretreatment results significant upregulation mucosal nmdar observed ibs patients compared controls significantly correlated abdominal pain discomfort scores intracolonic administration nmda normal mice produced increased colonic sensitivity colorectal distension elevated expression bdnf activation erk activation nmdar colonic epithelial cells vitro induced increased bdnf secretion cell supernatants higher bdnf expression cells well elevated phosphorylated erk conclusions study demonstrated activation mucosal nmdar colon may contribute visceral hypersensitivity ibs increasing production bdnf erk dependent pathway
belief paranormal psychic phenomena widespread united states third population believing extrasensory perception esp people believe others skeptical according cognitive differences hypothesis individual differences way people process information world contribute creation psychic beliefs differences memory accuracy selectively remembering fortune teller correct predictions analytical thinking relying intuition rather scrutinizing evidence hypothesis prevalent literature attempted empirically test provided comprehensive test cognitive differences hypothesis date studies used online screening recruit groups strong believers strong skeptics matched key demographics age sex years education groups tested laboratory online settings using multiple cognitive tasks measures cognitive testing showed consistent group differences tasks episodic memory distortion autobiographical memory distortion working memory capacity skeptics consistently outperformed believers several tasks tapping analytical logical thinking well vocabulary findings demonstrate cognitive similarities differences groups suggest differences analytical thinking conceptual knowledge might contribute development psychic beliefs also found psychic belief associated greater life satisfaction demonstrating benefits associated psychic beliefs highlighting role cognitive noncognitive factors understanding individual differences
rainwater harvesting rwh previously undertaken necessity commitment autonomy heralded sustainable alternative domestic water supply flood control disaster relief trinidad tobago wider caribbean region rwh included water security sustainability strategies despite plethora domestic rwh projects estimates water consumption rwh dependent households unavailable project designers left assume values based conventional water supply systems present study per capita consumption pcc domestic water three rwh dependent communities quantified purpose households perceived actual water consumption investigated three rural communities trinidad found perceived actual consumption per person per day lpd lpd respectively householders perception much water consumed generally significantly different measured amount sample measured pcc small results provide realistic values design rwh systems promoted region
elderly people constitute major portion world population many physically mentally vulnerable need continuous support health well growing trend elderly people placed ambient assisted living environment aal aim receive better care support settings lot attention given continuous health monitoring maintaining physical health status however much less attention given toward understanding entertainment needs elderly people important factor relevant mental health joyful living paper thus addresses entertainment needs elderly proposes framework elderly entertainment support system proposed framework enables different categories residents elderly people caregivers access various media services implicit explicit manner order enhance quality living experience different contexts experimental results demonstrate viability proposed framework believe proposed approach establish need develop entertainment systems services elderly people allow sensibly address problems associated independent happy active living
paper presents new hybrid desalination approach comprising evacuated solar water heater jut geotextile solar still evacuated solar water heater integrated desalination stills evaluate continuity production distillate two identical portable solar wick one basin solar stills designed evaluate systems performance jut linen woven fabrics stitched plane wick lengthwise crosswise integrated solar still jut fabrics used reduce rate water flow appropriate rate following variables studied single double layers wick plane wick lengthwise crosswise linen feeding hot water night two base slope angles wick still degrees theoretical analysis verified experiments water productivity increased conventional still double layer square wick dlsw solar still degrees base slope angle daily average efficiency dlsw experimentation distillate water productivity increased hot brackish water fed night time elsevier rights reserved
paper studies implements driver piezoelectric actuators discussed driver mainly composed flyback converter power operational amplifier opa flyback converter produces variable voltage supply opa outputs amplified sinusoidal signal bias drive piezoelectric actuator power losses reduced supply voltage opa varies peak input signal power conversion efficiency driver thus promoted experimental results implemented prototype possesses advantageous features nearly constant output input voltage gain high slew rate high input impedance low output impedance low output voltage ripples copyright john wiley sons ltd
recent decades water conservation become increasingly utmost important issue debate includes domestic sector reducing demand water improving efficiency water use domestic sector requires understanding water used ways water savings realized focus global web based consumer questionnaire survey analyze individual consumer attitudes towards using water manual dishwashing understand likelihood prospect changing daily manual dishwashing method resulting efficient domestic usage water study designed investigate manual dishwashing technique used households nine different countries china germany italy russia indonesia brazil india south africa argentina besides socio demographics technical questions like cleaning steps hygiene questions motivational question environmental awareness questions questions payment water electricity questions information sources household work included study found awareness conserve water common among asian participants necessarily practiced households individual washing dishes found quite high among many outcomes important one running tap method found prevalent among russian participants complimenting detached approach towards conserving domestic water usage south american countries like brazil argentina high occurrence running tap rinse found common practice confirming lack conscious use water manual dishwashing subcontinent based overall responses awareness new efficient technique manual dishwashing could propagated voted mediums internet
new configurations realizing inverse lowpass inverse bandpass inverse highpass inverse bandreject filters using commercially available current feedback amps cfoa accessible terminal presented workability proposed circuits confirmed experimental results employing type cfoas
paper presents ist rely project aims integrating satellite digital radio broadcasting terrestrial cellular technology egnos satellite navigation
interface shear strength soil structural materials dependent confining pressure increase confining pressure different methods reinforcement materials carbon fiber reinforced polymer cfrp used shear strength cfrp improved soil dependent interface properties soil cfrp objective study investigate interface properties friction angle adhesion sand frp experimentally using direct shear test apparatus increase surface roughness improve interface properties layer sand placed saturated carbon fiber curing period spark plasma sintering cfrp spscfrp normal stress applied sand interface shear tests conducted different curing times shear rates normal stresses spscfrp curing time tests showed normal stress spscfrp curing time increased friction angle increased however increasing curing times rate shearing small influence interface properties
use probiotic therapy active area investigation treat intestinal disorders clinical benefits probiotic formula lactobacillus plantarum cect cect acidilactici cect demonstrated irritable bowel syndrome ibs patients randomized double blind placebo controlled clinical trial aim study evaluate therapeutic effects two experimental models colitis dextran sulfate sodium dss induced colitis model interleukin deficient mice model colitis induced week old balb mice administering dss drinking water days probiotics administered orally vsl cfu daily days administration dss also probiotics vsl cfu daily administered orally week old cbj mice weeks body weight recorded daily colon samples harvested histological examination cytokine measurements body weight dss administration change group whereas vsl group weight loss also normalized levels similar healthy controls significantly increased reparative histologic score deficient model vsl reduced severity colitis compared untreated controls significantly reduced levels ifn gamma compared two groups conclusion displays protective effect two murine models experimental colitis results suggest mechanism action could different vsl
large body literature attachment styles personality traits purpose study compare two commonly used instruments attachment measure secure fearful dismissing preoccupied styles furthermore sought determine personality factors facets common attachment measures overall undergraduates completed demographic measure two attachment scales rsq neo measure personality found high concordance neo factors facets predicted rsq attachment measures attachment secure style associated lower neuroticism higher extraversion fearful attachment consistently predicted female higher neuroticism specifically depression well lower extraversion agreeableness specifically trust individuals scoring higher preoccupied attachment higher neuroticism specifically depression lower agreeableness finally individuals scoring higher dismissing attachment lower trust results confirm griffin bartholemew conceptualization attachment falling dimensions anxiety avoidance individuals higher anxiety higher neuroticism lower agreeableness higher avoidance lower levels trust crown copyright published elsevier ltd rights reserved
paper focuses extending recently proposed damage localization method previously devised structures subjected known input ambient vibrations induced unknown wind excitation wind induced vibrations long span bridges recorded without closing infrastructure traffic providing useful data health monitoring purposes one major problem damage identification large civil structures scarce data recorded damaged real structures detailed finite element model able correctly reliably reproduce real structure behavior ambient excitation invaluable tool enabling simulation several different damage scenarios test performance monitoring system work calibrated finite element model existing long span suspension bridge used simulate structural response wind actions several damage scenarios simulated different location severity damage check sensitivity adopted identification method sensitivity length noise disturbances recorded data also investigated
paper presents design mixed signal pulse width modulator mspwm integrated circuit targets digital control high frequency switched mode power supplies smps previous designs consider digital pulse width modulators dpwm implementations encounter important design issues power consumption non linearity layout dependency trimming capability temperature dependency work presents effective solutions suitable large scale production ics since combines high precision high linearity temperature independent standard analog circuits commonly offered semiconductor industry simplicity reuse digital pid compensation input bit prototype designed cmos process operates switching frequency mhz draws supply takes including non overlapping control logic smps power devices elsevier rights reserved
objective study assessed mode application oral intravenous subcutaneous currently employed treatment rheumatoid arthritis patients qatar comparison patients individual preferences mode application treatment methods study included patients visiting three clinics main referral hospital qatar interviewed using standard questionnaire determine preference mode application disease modifying antirheumatic drug dmard treatment relation currently employed mode application results majority patients female male patients female patients study clinics nationality qatari highest patient preference recorded oral therapy compared injection intravenous therapy total patients expressed preference remain oral therapy compared intravenous injection patients indicating preference remain current method administration conclusions high preference oral therapies highlights considerable need incorporation new oral targeted synthetic dmard therapies clinical practice within region
study equilibrium isotherms kinetics thermodynamics ciprofloxacin seven sediments batch sorption process examined effects contact time initial ciprofloxacin concentration temperature ionic strength sorption process studied parameter linear sorption model determined linear regression analysis freundlich dubinin radushkevich sorption models applied describe equilibrium isotherms linear nonlinear methods estimated values varied obtained values free energy estimated isotherm model mol indicated physical nature ciprofloxacin sorption studied sediments according obtained values measure intensity sorption estimate freundlich isotherm model ciprofloxacin sorption sediments categorized poor moderately difficult sorption characteristics kinetics data best fitted pseudo secondorder model thermodynamic parameters including gibbs free energy delta degrees enthalpy delta degrees entropy delta degrees calculated estimate nature ciprofloxacin sorption results suggested sorption sediments spontaneous exothermic process
texture feature extraction methods improved greatly recent years widely known local texture feature descriptor achieve desired performance change image geometric size different poses complex illumination conditions paper novel local texture descriptor proposed named multi degrees improved local difference binary ildb local difference binary promising feature description method computes intensity gradient difference pairwise grid cells ignores image grid inherent texture gradient difference ildb represent difference texture information grid cells intensity gradient simultaneously addition multiple degree strategy adopted achieve richer texture description time optimized mutual information proposed capture discriminant feature selection reduce dimensionality ildb experimental results demonstrate proposed method highly efficient distinctive compared several state art approaches due good performance ildb expected ildb potential widespread application many computer vision fields
exploratory research aims evaluate indoor environmental quality classrooms three school buildings southern manitoba canada evaluate well schools teachers pertains perception classrooms indoor environment schools include middle aged conventional school new non green school new green school certified using leadership energy environmental design rating system methodology involved using mobile instrument cart conduct snapshot measurements thermal comfort indoor air quality lighting acoustics classrooms occupant survey evaluate teachers long term satisfaction classrooms indoor environmental quality results showed new green new non green schools classrooms performed better conventional middle aged school classrooms respect aspects thermal comfort indoor air quality teachers new green school new non green school satisfied teachers conventional middle aged school classrooms overall indoor environmental quality lighting quality indoor air quality surprisingly new green new non green school classrooms performance comparable new green school classrooms performing statistically significantly better respect relative humidity similarly none differences teachers satisfaction ratings new green new non green school statistically significant
previous research suggested expectancy eating rewarding one pathway driving relationship trait reward sensitivity externally driven eating aim current study extend previous research examining conditions indirect effect reward sensitivity external eating via eating expectancy occurs using conditional indirect effects approach tested moderating effect exposure food cues images relative non food cues association reward sensitivity external eating via eating expectancies participants years age university women completed computerised food expectancies task task randomly assigned either appetitive food cue condition non food cue condition responded series eating expectancy statements self description personality statements participants also completed self report trait measures reward sensitivity addition measures eating expectancies endorsement belief eating rewarding experience results revealed higher reward sensitivity associated faster reaction times eating expectancies statement moderated cue condition association reward sensitivity faster reaction time found food cue condition faster endorsement belief reaction time also associated greater external eating results provide additional support proposal individuals high reward sensitivity form implicit associations positive beliefs eating exposed food cues elsevier ltd rights reserved
mathematical modeling powerful tool predicting investigating cardiovascular diseases shown lumped parameter model draw analogy electrical circuits fluid flow provide simple effective method modeling human cardiovascular system order build patient specific model practically feasible estimate numerous model parameters electrical structural patient specific data measurements however estimation may possible optimal measurement locations identified important model parameters complementary optimal time regions thus sensitivity analysis used identify important parameters well optimal measurement locations optimal time regions pressure flow waves study applied parametric local sensitivity analysis linear elastic lumped parameter model arm arteries without anastomosis identify important electrical structural parameters ultimate goal study provide guidance experimentalists measure pressure flow network locations order estimate key model parameters first steps required build patient specific model elsevier inc rights reserved
objectives proof concept trial examined feasibility preliminary efficacy understanding social situations uss new social cognitive intervention targets higher level social cognitive skills using methods common neurocognitive remediation including drill practice hierarchically structured training may compensate negative effects cognitive impairment learning method thirty eight individuals schizophrenia spectrum disorders completed baseline assessment cognitive social cognitive functioning twice month period minimize later practice effects received sessions uss training completed assessment posttreatment results uss training well tolerated received high treatment satisfaction ratings large improvements uss skills test contained items similar identical training stimuli suggest effective teaching specific training content content gains generalized improvements social cognitive tasks including select measures attributional bias theory mind importantly baseline neurocognition impact amount learning uss indexed uss skills test amount improvement social cognitive measures conclusions implications practice uss shows promise treatment higher level social cognitive skills given lack relationship baseline cognition treatment effects may particularly appropriate individuals lower range cognitive function
ethnopharmacological relevance plant based traditional medicines birth control practice rural populations north east india since time immemorial fresh rhizome drynaria quercifolia smith one plant parts used traditionally different ethnic communities tripura india birth control present investigation aimed justify scientific basis traditional use drynaria quercifolia rhizome anti fertility agent materials methods vivo uterotonic activity done uterine tissue acute toxicity test plant extract carried rats sexes abortifacient anti implantation activities extract investigated vivo estimated level different hormones release results result revealed effectiveness methanol aqueous extract plant uterotonic activity extracts showed relatively non toxic effect acute toxicity study methanolic extract shown higher efficacy abortifacient anti implantation performance also effected hormone release level conclusion methanolic extract diynaria quercifolia smith rhizome proved significant anti fertility activity elsevier ireland ltd rights reserved
paper discusses problem output power maximization low power wind energy conversion systems operated partial load systems generally based multi polar permanent magnet synchronous generators exhibit significant efficiency variations operating range unlike high power systems whose mechanical electrical conversion efficiency high practically modify global optimum low power systems global conversion efficiency affected generator behavior electrical power optimization longer equivalent mechanical power optimization system efficiency analyzed using maxima locus mechanical power versus rotational speed characteristics maxima locus electrical power delivered versus rotational speed characteristics experimental investigation carried using torque controlled generator taken real world wind turbine coupled physically simulated wind turbine rotor experimental results indeed show steady state performance conversion system strongly determined generator behavior control solutions aiming maximizing energy efficiency envisaged thoroughly compared experimental results elsevier ltd rights reserved
article review several intelligent robotic algorithm approaches propose novel neural network based approach nonlinear systems nonlinear systems represented nonlinear takagi sugeno models linear differential inclusion ldi state space representation utilized deal stability analysis control problems oceanic structures stability conditions neural fuzzy logic criteria derived utilizing ldi representation stability analysis via lyapunov theory guarantee stability time delay tension leg platform tlp system
recent electrophysiological study suggests existing compensatory brain activity mechanism functional recovery visual attention detection capacity detecting external cues symptomatically remitted schizophrenia patients despite evidence little known aspects attentional related processes schizophrenia clinical remission capacity concentrate task hands without interfered distracting information end recorded event related brain potentials erps symptomatically remitted schizophrenia patients healthy controls engaged classic stroop task symptomatically remitted patients showed comparable stroop interference healthy controls indicating degree functional recovery capacity patients neural level fronto central central regions component erps related conflict detection found across groups although patients presented reduced relative healthy controls contrast amplitude sustained potential parieto central parietal regions component erps related conflict resolution significantly increased patients relative healthy controls furthermore increased amplitude correlated positively improved behavioral accuracy symptomatically remitted patients schizophrenia findings reveal symptomatically remitted patients schizophrenia increasingly recruited parietal activity involving successful conflict resolution offset reduced conflict detection therefore provides insight compensatory mechanisms potentially involving degree functional recovery attentional related processes schizophrenia clinical remission
background public health organisations national health service united kingdom national institutes health united states provide access online libraries publicly endorsed smartphone applications apps however little evidence users rely guidance rather one common methods finding new apps search online store hundreds smoking cessation alcohol related apps currently available market smokers drinkers must actively choose app download prior engaging influences choice yet identified study aimed investigate design features shape users choice smoking cessation alcohol reduction apps design features judged important engagement methods adult smokers drinkers interested using app quit cut asked search online store identify explore smoking cessation alcohol reduction app choice whilst thinking aloud semi structured interview techniques used allow participants elaborate statements interpretivist theoretical framework informed analysis verbal reports audio recorded transcribed verbatim analysed using inductive thematic analysis results participants chose apps based immediate look feel quality judged others ratings brand recognition social proof titles judged realistic relevant monitoring feedback goal setting rewards prompts identified important engagement fostering motivation autonomy tailoring content non judgmental communication style privacy accuracy viewed important engagement fostering sense personal relevance trust sharing progress social media use craving management techniques social settings judged engaging concerns others negative reactions conclusions choice smoking cessation alcohol reduction app may influenced immediate look feel social proof titles appear realistic design features enhance motivation autonomy personal relevance credibility may important engagement
beta epsilon hopset weighted undirected vertex graph set edges whose addition graph guarantees every pair vertices path contains beta edges whose length within epsilon shortest path seminal paper cohen jacm introduced notion hopsets context parallel computation approximate shortest paths since found numerous applications various settings dynamic graph algorithms distributed computing streaming model cohen devised efficient algorithms constructing hopsets polylogarithmic number hops constructions remain state art since publication paper stoc two decades paper exhibit first construction sparse hopsets constant number hops also find efficient algorithms hopsets various computational settings improving best known constructions generally hopsets strictly outperform hopsets terms parameters terms resources required construct demonstrate applicability results fundamental problem computing approximate shortest paths sources results improve running time problem parallel distributed streaming models vast range
article considers contribution consultancy research might make resolving communication problems women identified leadership practices within intersecting fields gender language workplace discourse consultancy research practitioner commissioned research resolve work related communication problems still uncommon article presents study monika senior leader engineering company commissioned find experiencing communication problems teams using interactional sociolinguistic analysis able show monika authority resisted gendered linguistic grounds making case consultancy research discuss might use insights discourse analysis offer guidance practitioners seeking help
purpose study identify several responsible parameters back pain youth soccer players create risk assessment tool early prevention ipad based survey used screen parameters cross sectional study questionnaire includes items regarding anthropometric data training habits sports injuries put practice athletes sex odds ratio age group playing surface significantly associated history injuries especially spine hip groin increased likelihood evolving recurrent overall factors seem influence appearance pain integrated feasible nomogram nomogram provides practical tool identify risks developing youth soccer players although factors identified non modifiable method allows rank importance factors especially prevention treatments athletes
since long term performance subway tunnels largely determined deformation soil around study soil deformation characteristics subway vehicle loads important especially soft soil area based series dynamic cyclic triaxial tests deformation characteristics saturated mucky clay guangzhou studied result shows failure cyclic stress amplitudes csa failure cyclic stress ratio occur recoverable strain accumulative plastic strain reaches approximately respectively accordingly development cyclic plastic strain categorized three types steady state rapid growth instantaneous failure stress level failure csa development recoverable strain nearly linear accumulative plastic strain prevent control engineering geological hazards induced subway vehicle loads vibration amplitudes mucky clay around subway tunnel axis must closely monitored attention must paid soil deformation early operation stages subway line mucky clay sensitive external loads strength soil shallow ground considered basic parameters study design results paper contribute design maintenance subway tunnels well prevention control tunnel axis deformation
aimsexplorations freshwater cyanobacteria antimicrobial bacteria fungi methicillin resistant staphylococcus aureus mrsa strains drug resource using bioassay nrps non ribosomal polypeptide synthetase pks polyketide synthase genes well silico approach methods resultswe bioassayed extracts phormidium ccc geitlerinema ccc arthrospira ccc leptolyngbya ccc phormidium ccc phormidium ccc six pathogenic bacteria comprising gram aureus including seven clinical mrsa enterococcus faecalis gram escherichia coli salmonella typhimurium klebsiella pneumoniae shigella boydii along non pathogenic enterobacter aerogenes well fungal strains cryptococcus neoformans candida albicans krusei tropicalis aspergillus niger exhibiting antimicrobial potential nrps pks genes target strains also amplified sequenced putative protein structures predicted using bioinformatics approach conclusionpks gene expression indicated keto acyl synthase one important active domains biomolecules related antitumour antifungal group simultaneous identification biomolecule dihydro pyran one derivative also inferred spectroscopically significance impact studyfreshwater cyanobacteria prolific producers secondary metabolite may act antimicrobial drug resource addition much explored marine counterpart
physiological functions vascular endothelial cells ecs vary depending wall shear stress wss magnitude functional change affects pathologies various cardiovascular systems several vitro vivo models used investigate functions ecs different wss conditions however models technical limitations precisely mimicking physiological environments ecs monitoring temporal variations ecs detail although zebrafish danio rerio several strategies overcome technical limitations zebrafish used perfect animal model applying various wss conditions blood vessels zebrafish difficult study proposes new zebrafish model various wss applied caudal vein wss magnitude controlled blocking parts blood vessel networks accuracy reproducibility proposed method validated using equivalent circuit model blood vessels zebrafish proposed method applied lipopolysaccharide lps stimulated zebrafish typical application proposed zebrafish model used vivo animal model investigate relationship wss physiology wss induced cardiovascular diseases
change impact analysis process determining consequences modification software theory change impact analysis done software maintenance make sure changes introduce new bugs many approaches techniques proposed help programmers change impact analysis automatically however still open question whether programmers change impact analysis paper conducted two studies one depth study one breadth study depth study recorded videos nine professional programmers repairing two bugs two hours breadth study surveyed professional programmers using online system found programmers studies static change impact analysis made changes using ide navigational functionalities dynamic change impact analysis made changes running programs also found use change impact analysis tools
although personality disorders pds highly comorbid bipolar spectrum disorders bsds little longitudinal research conducted examine prospective impact symptoms course bsds aim study examine whether symptom severity predicts shorter time onset bipolar mood episodes conversion bipolar disorder time among individuals less severe bsds participants bipolar disorder cyclothymia bipolar disorder otherwise specified completed diagnostic interview assessments symptoms self report measures mood symptoms baseline followed prospectively diagnostic interviews every months average years cox proportional hazard regression analyses indicated overall symptom severity significantly predicted shorter time onset hypomanic hazard ratio major depressive episodes conversion bipolar disorder controlling mood symptoms results also suggested cluster severity predicted shorter time onset hypomanic episodes major depressive episodes conversion bipolar disorder whereas cluster severity predicted shorter time onset major depressive episodes results support predisposition models suggesting symptoms may act risk factor severe course bsds
pirfenidone antifibrotic drug recently approved treatment patients idiopathic pulmonary fibrosis ipf although pirfenidone exhibits anti inflammatory antioxidant antifibrotic properties molecular mechanis munderlying protective effects remains unknown link pirfenidone action regulation profibrotic hedgehog signaling pathway demonstrate pirfenidone selectively destabilizes glioma associated oncogene homolog gli protein primary activator mediated gene transcription consequently pirfenidone decreases overall pathway activity patients ipf patient derived primary lung fibroblasts leads diminished levels target genes gli receptor patched alpha smooth muscle actin fibronectin reduced cell migration proliferation interestingly triggered tgf beta expression potentiated responsiveness primary lung fibroblasts elevating available pool glioma associated oncogene homolog gli gli thus creating vicious cycle amplifying fibrotic processes gli transcription factors crucial mediated changes also required mediators tgf beta signaling findings suggest pirfenidone exerts clinically beneficial effects dual tgf beta inhibitionby targeting gli protein didiasova singh wilhelm wapiszewska wujak zakrzewicz schaefer markart seeger lauth wygrecka pirfenidone exerts antifibrotic effects inhibition gli transcription factors
background patients advanced heart failure enroll hospice low rates data acute medical service utilization hospice enrollment limited methods results performed descriptive analysis medicare fee service beneficiaries least one home health claim july june least hospitalizations july december subsequently enrolled hospice july december estimated panel negative binomial models subset beneficiaries compare acute medical service utilization enrollment sample size included beneficiaries female years age non white mean comorbidity count standard deviation median number days second hospital discharge hospice enrollment median number days enrolled hospice beneficiaries died within days enrollment study period beneficiaries disenrolled hospice least adjusted mean number hospital intensive care unit emergency room admissions decreased hospice enrollment hospice enrollment conclusions home health care medicare beneficiaries advanced enrolled hospice lower acute medical service utilization enrollment pattern hospice use suggests earlier referral improved retention may benefit population research necessary understand hospice referral palliative care needs advanced patients
paper researches small size unmanned helicopter attitude control problem actuator saturation limit traditional approach problem often based accurate dynamic model complicated difficult achieve engineering paper propose anti windup pid approach rely sophicated helicopter dynamic model anti windup pid controller established adding phase lead compensator conventional pid controller performance merits proposed controller exemplified simulations conventional pid controller anti windup pid controller
article discusses potential bns complement analytical toolkit agricultural extension statistical modelling adoption agricultural practices tended use categorical logit probit regression models focusing single technology practice explained number household farm characteristics bayesian network used model household level data adoption agrosilvopastoral practices tiby mali discuss advantages bns modelling complex data structures including multiple practices implemented jointly farms correlation probabilities implementation practices iii correlation household farm characteristics paper demonstrates use bns deductive reasoning regarding adoption practices answering questions regarding probability implementation combinations practices conditional household characteristics bns complementary modelling approach logistic regression analysis facilitates exploring causal structures data deciding reduced form regression model uniquely bns used inductively answer questions regarding likelihood certain household characteristics conditional certain practices adopted
connecticut nutmeg state games sport athletic event involved athletes cmd took place days july new county sport medical coverage games orchestrated chirapractors one hundred fortyone athletes required total medical contacts total injury incidence rate majority injuries minor sprains strains contrusions abrasions injuries occurred lower extremities bulk injuries treated adequately ice compression bandages adhesive bandages basic first aid supplies incidence injury higher contact sports football field hockey soccer reporting injuries pet participant coverage events requires proficiency basic first aid cardiopulmonary resuscitation treatment soft tissue injuries emphasis lower extremities injuries
study evaluated efficacy interactive media based computer delivered depression treatment program imbpst compared treatment control condition ntc parallel group randomized controlled trial conducted outpatient psychiatric research clinic adult participants major depressive disorder dysthymia randomized receive either weekly sessions imbpst treatment treatment control ntc primary outcome measure beck depression inventory bdi significant group time interaction effect eta cohens patients receiving imbpst significantly greater reduction depressive symptoms compared patients ntc condition participants imbpst group improved depression symptoms significantly moderate bdi mild levels depression bdi receiving weekly sessions imbpst progressed still milder levels depression six weekly sessions bdi ntc participants showed significant reduction bdi scores bdi pre post additionally imbpst group showed clinically significant reliable change depression levels none ntc group met criterion imbpst participants rated program highly usable system usability scale sus first session sus session usability scores increased significantly last session sus session conclude imbpst effective engaging easily used depression treatment program warrants evaluation heterogeneous depressed populations stand alone self administered fashion
currently educational games developed teach children basics computer programming research design games usually based general learning theories yet computer programming poses specific types difficulties novice programmers taking account particular characteristics problems computer programming learning content design programming games could allow producing games suitable needs novice programmers paper first reports novice programmer problems analysis gain insight learners specific difficulties review existing programming games presented investigate extent games deal specific programming problems results studies aim contribute requirements ideation phases programming game design process thereby informing learning content driven design perspective
molecular determinants pathogenic leukocyte migration across blood nerve barrier bnb chronic inflammatory demyelinating polyradiculoneuropathy cidp unknown specific disease modifying therapies cidp also lacking fibronectin connecting segment fncs alternatively spliced fibronectin variant expressed microvascular endothelial cells sites inflammation vitro situ counterligand leukocyte alpha integrin also known cdd implicated pathogenic leukocyte trafficking multiple sclerosis inflammatory bowel disease sought determine role fncs cidp patient leukocyte trafficking across bnb vitro severe chronic demyelinating neuritis vivo using representative spontaneous murine cidp model peripheral blood mononuclear leukocytes untreated cidp patients independently infused cytokine treated flow dependent vitro bnb model system time lapse digital video microscopy performed visualize quantify leukocyte trafficking comparing fncs peptide blockade relevant controls fifty week old female deficient non obese diabetic mice spontaneous autoimmune peripheral polyneuropathy sapp treated daily fncs peptide days via intraperitoneal injection appropriate controls neurobehavioral measures disease severity motor nerve electrophysiology assessments histopathological quantification inflammation morphometric assessment demyelination performed determine vivo efficacy biological relevance fncs cdd cidp evaluated immunohistochemical detection affected patient sural nerve biopsies fncs peptide maximally inhibited cidp leukocyte trafficking human bnb vitro fncs peptide treatment resulted significant improvements disease severity motor electrophysiological parameters demyelination histological measures inflammatory demyelination microvessels demonstrating fncs expression cdd leukocytes seen within endoneurium patient nerve biopsies taken together results imply role fncs pathogenic leukocyte trafficking cidp providing potential target therapeutic modulation elsevier inc rights reserved
work describes functional structural transitions novel protease isolated conidiobolus brefeldianus mtcc cprot detail using biophysical bioinformatics tools commercial importance cprot silk leather industries made interesting candidate structural investigations cprot possesses alpha helix beta sheet turns enzyme found active wide range degrees protease also stable organic solvents concentration alcohols dmso guanidine hydrochloride cprot also resistant trypsin chymotrypsin proteinase fluorinated alcohols melting temperatures observed native cprot enzyme treated various stress conditions correlated well corresponding structural functional transitions obtained structural information supported homology model closest homologue coronatus revealing similarity clan proteases proteases mixed nucleophile superfamily asp ser putative catalytic triad three tryptophan residues cprot surrounded positively charged residues evident solute quenching studies homology model elsevier rights reserved
deterioration electromagnetic environment microcontroller unit mcu electromagnetic susceptibility ems transient burst interference become focus academia enterprise electromagnetic compatibility emc studies mcus taken effects aging account however component aging degrade physical parameters mcu change immunity emi paper proposes time equivalent interval accelerated aging methodology combining electrical high temperature stresses test results show variations susceptibility electrical fast transients eft burst revealing increasing susceptibility reasons mcu immunity drifts aging process discussed elsevier ltd rights reserved
feature selection significant task data mining machine learning applications eliminates irrelevant redundant features improves learning performance many real world applications collecting labeled data difficult abundant unlabeled data easily accessible motivates researchers develop semi supervised feature selection methods use labeled unlabeled data evaluate feature relevance however till date comprehensive survey covering semi supervised feature selection methods paper semi supervised feature selection methods fully investigated two taxonomies methods presented based two different perspectives represent hierarchical structure semi supervised feature selection methods first perspective based basic taxonomy feature selection methods second one based taxonomy semi supervised learning methods survey helpful researcher obtain deep background semi supervised feature selection methods choose proper semi supervised feature selection method based hierarchical structure
trust management become emerging security paradigm various areas hoc networks cloud computing one core element trust management indirect trust model evaluates trustworthiness target based others recommendations research indirect trust still early stage problems addressed yet subjectivity trust entities would different views target consequently receiving recommendations evaluating entity first measure credibility existing methods often distort recommendations propose reasonable method based similarity recommenders evaluating entities furthermore considering characteristics one hop multi hop recommendations similarity calculation methods developed individually another problem spoofed recommendations aiming tarnishing someone harboring conspirators design simple efficient algorithm detect remove proposed methods algorithms constitute integrated indirect trust model model bound specific domain thus widely applied simulation results show model effective obtaining objective indirect trust value existence personalized dishonest recommenders copyright john wiley sons ltd
realistic rendering natural scenes captured digital cameras ultimate goal image processing recent years high dynamic range hdr imaging received increasing attention producing high quality images multi exposure image fusion one popular methods achieve hdr like image without tone mapping however existing fusion methods may result serious color distortions due inappropriate image attribute selection paper propose multi exposure image fusion method based human visual perception overall image quality index oiq local saturation adopt oiq local saturation enhance fusion quality multi exposure images achieve natural color reproduction experimental results show proposed method successfully enhance image quality achieve realistic rendering natural scenes
paper examines evidence delusions explained within framework neurocognitive model brain assesses certainty certainty refers low level interpretations one environment high level conscious appraisals one beliefs experiences model proposed explaining brain systems responsible assigning certainty might dysfunction contributing cause maintenance delusional beliefs suggested delusions arise combination perturbed striatal dopamine aberrant salience well cognitive biases tendency jump conclusions jtc hypersalience evidence hypothesis matches role emotion stress trauma sociocultural factors forming modifying delusions also considered understanding mechanisms involved forming maintaining delusions important clinical implications interventions improve cognitive flexibility cognitive remediation therapy mindfulness training could potentially attenuate neurocognitive processes
broadly speaking supervised machine learning computational task learning correlations variables annotated data training set using information create predictive model capable inferring annotations new data whose annotations known ageing complex process affects nearly animal species process studied several levels abstraction different organisms different objectives mind surprisingly diversity supervised machine learning algorithms applied answer biological questions reflects complexities underlying ageing processes studied many works using supervised machine learning study ageing process recently published timely review works discuss main findings weaknesses summary main findings reviewed papers link specific types dna repair ageing ageing related proteins tend highly connected seem play central role molecular pathways ageing longevity linked autophagy apoptosis nutrient receptor genes copper iron ion transport additionally several biomarkers ageing found machine learning despite interesting machine learning results also identified weakness current works topic one reviewed papers corroborated computational results machine learning algorithms wet lab experiments conclusion supervised machine learning contributed advance knowledge provided novel insights ageing yet future work greater emphasis validating predictions
civil engineering projects increasingly involve wide range stakeholders diverse interests multidisciplinary teams engineers need soft skills deal teams stakeholders educate soft skills engineering students central question technical universities course collaborative design engineering dutch master programme construction management engineering answer question feedback however indicated course meet expectations course needed radical redesign paper describes redesign resulting framework course principles redesign constructive alignment activated learning lecture skills dry stuff resulting course based pressure cooker coaching framework pressure cooker part creates situation students experience stress students work large groups complex assignment time pressure mix group individual assignments creates tension students coaching part provides structure guidance theory necessary soft skills introduced early course workshops consultation meetings help keep students track course evolved three years theoretical evaluation shows pressure cooker coaching framework fulfills requirements constructive alignment practical evaluation using feedback shows consistent high score consider pressure cooker coaching framework broadly applicable successful enough continue cde course elements course improved consider introducing theoretical depth psychology without violating idea dry stuff action learning
glucose concentration human body significant indicative diabetes screening significant develop rapid sensitive methods glucose detection herein cose reduced graphene oxide cose rgo nanohybrids synthesized via simple convenient hydrothermal method also morphologies compositions systematically characterized cose rgo nanohybrids found possess intrinsic peroxidase like activity effectively catalyze oxidation tetramethylbenzidine tmb presence hydrogen peroxide accompanied blue color change catalytic activity cose rgo nanohybrids matched typical michaelis menten kinetics highly dependent reaction time incubation temperature concentration peroxidase like cose rgo nanohybrids successfully applied detection glucose detection limit low respectively furthermore carbohydrates lactose sucrose galactose fructose interferences detection glucose detection platforms glucose developed present work confirmed cose rgo nanohybrids possess intrinsic peroxidase like activity also showed great potential applications varieties simple robust easy make analytical approaches future elsevier rights reserved
smart grid system uses information communication technologies integrate intelligent way users connected electrical power system considering behaviour actions purpose information electrical network current voltage power gathered together time behaviour suppliers consumers observed automatically coordinated smart grids becoming significant part configuration future electrical power systems lot research done using smart grids achieve highly efficient user friendly electrical power systems many new methods introduced solve difficulties energy providers face transforming conventional electrical networks smart grids difficulties include integration renewable energy different grid systems national international levels due changes frequency voltage synchronisation mechanism paper provides outline european smart grid projects gives overview current infrastructure smart grid applications turkish electricity production system operator euas turkish electricity transmission system operator teias turkish electricity distribution system operator tedas paper feasibility steps required described assessments made suggestions given smart grid developments general elsevier ltd rights reserved
floods become frequent occurrence every part world field flood hydraulics keenly studied enhance understanding processes impacts environment main impacts frequent floods incidents soil erosion phenomenon leads sedimentation problems drainage river systems extremely important understand sedimentation process flow behaviour patterns water course post flood events experimental investigations overbank flow mobile bed straight channels undertaken significant changes bed morphology due changes flow behaviour studied findings roughness coefficient lateral distribution stream wise velocity secondary currents bed shear stress bed formation presented paper results show resistance coefficient increased flow depth channel increments floodplain main channel sections respectively
remote sensing estimation forest stand height ever challenging issue due difficulties encountered acquisition data forest canopies stereo optical imaging offers high spatial spectral resolution however optical correlation lower dense forests open areas due insufficient number matching points therefore cases height information may missing faulty long wavelengths band band synthetic aperture radars capable penetrating forest canopies low spatial resolutions restrict use single tree based forest applications study airborne laser scanning used effective remote sensing technique produce large scale maps forest stand height technique produces high resolution point clouds high penetration capability allows detection multiple echoes per laser pulse study area forest coverage approximately selected houston usa three dimensional color coded map forest stands produced using normalized digital surface model technique rather limited number ground control points accuracy produced map assessed model model approach using terrestrial laser scanning accuracy assessment standard deviation used main accuracy indicator addition root mean square error normalized median absolute deviation absolute geo location accuracy generated map found better horizontally approximately height furthermore effects bias relative standard deviations determined problems encountered production map well recommended solutions also discussed paper
nowadays increasing number cloud users including individuals enterprises store internet things data cloud benefits like cost saving however cloud storage service often regarded untrusted due loss direct control data hence necessary verify integrity data cloud storage servers via third party real cloud systems important improve performance auditing protocol hence well designed cost effective auditing protocol expected meet performance requirement data size large real cloud systems article also propose auditing protocol based pairing based cryptography reduce computation cost compared state art third party auditing protocol moreover also study determine number sectors achieve optimal performance auditing protocol case challenged data equation computing optimal number sectors proposed improve performance auditing protocol mathematical analysis method experiment results show solution efficient
context pediatric abusive head trauma aht defined injury skull intracranial contents child age due inflicted blunt impact violent shaking evidence acquisition ahtis commoncause traumatic death children younger year leading cause death due child abuse clinical presentation observed children aht depends type aht accompanying injuries history physical examination important diagnosing aht distinguishing conditions mimic shaken baby syndrome accidental trauma cancer metabolic diseases others results progress research medical diagnosis aht remarkable development treatment strategies limited reasons urgent need develop effective treatment strategies aht able improve outcomes conclusions construction nationwide database supports clinical studies required future
although significant improvements made treatment acute lymphoblastic leukemia substantial subset high risk cell patients relatively poor prognosis like leukemia types alterations pik mtor pathway predominant also responsible treatment failure relapse study show relapsed patients display enrichment mtor pathway using panel inhibitors targeting multiple components pik mtor pathway observed dual specific pik mtor inhibitor pki selective inhibitor cells dependent pik mtor pathway furthermore observed pki blocked proliferation colony formation cell lines additionally selectively abrogated pik mtor signaling without affecting mapk signaling vitro vivo inhibition pik mtor pathway using pki delayed tumor progression reduced tumor load enhanced survival rate immune deficient mouse xenograft models without inducing weight loss inhibitor treated mice preclinical study shows beneficial effects pict warrants investigation clinical setting elsevier rights reserved
functional gastrointestinal disorders fgids diagnosed classified using rome criteria criteria may change time new scientific data emerge rome released may aim review main changes rome fgids called disorders gut brain interaction dgbi rome multicultural rather western culture focus new chapters including multicultural age gender women health intestinal microenvironment biopsychosocial centrally mediated disorders new disorders included although truly fgids fit new definition dgbi including opioid induced gastrointestinal hyperalgesia opioid induced constipation cannabinoid hyperemesis also new fgids based available evidence including reflux hypersensitivity centrally mediated abdominal pain syndrome using normative survey determine frequency normal bowel symptoms general population changes time frame diagnosis introduced irritable bowel syndrome ibs pain required discomfort eliminated non specific different meanings different languages pain related bowel movements rather improving bowel movements get worse bowel movement functional bowel disorders functional diarrhea functional constipation ibs predominant diarrhea ibs ibs predominant constipation ibs ibs mixed bowel habits considered continuum rather independent entities clinical applications diagnostic algorithms multidimensional clinical profile updated new rome iteration evidence based multicultural oriented clinical applications new evidence become available future updates expected
present study investigates prediction efficiency nonlinear system identification models assessing behavior coupled structure passive vibration controller two system identification models including nonlinear autoregresive exogenous inputs narx adaptive neuro fuzzy inference system anfis used model behavior experimentally scaled three story building incorporated tuned mass damper tmd subjected seismic loads experimental study performed generate input output data sets training testing designed models parameters root mean squared error mean absolute error determination coefficient statistics used compare performance aforementioned models tmd controller system works efficiently mitigate structural vibration results revealed narx anfis models could used identify response controlled structure parameters two time delays structure response seismic load proven effective tools identifying performance models comparison based parametric evaluation two methods showed narx model outperforms anfis model identifying structures response
article summarizes results researches processes gas jet turbulence formation cylinders gas internal combustion engine factor gas fuel combustion influence environmental safety vehicles method assessment air fuel mixture turbulence formation gas engine developed basis vector analysis published elsevier
drilling oil gas wells utilize drilling mechanical energy crush formation rocks drill bits due friction formation rocks bit cutters suffer continuous wear progress drilling causing reduction rate penetration real time bit wear challenge drilling absolute physical model paper presents new philosophy based control engineering systems simulate bit behavior estimate transferred wasted mechanical energy predict drilling performance efficiency analytical model developed predict drilling performance analyzing real time transferred drilling mechanical energy consumed drill bits model assist optimizing hydraulic energy take proper time decision pull dulled bits model consists first order differential equation solved predict effect drilling parameters drill bit wear bit wear equation enters second order differential equation solved laplace transformation expressed transfer function representation allows analyzing drilling performance also expressed real time bit displacement achieved input drilling energy poles denominator transfer function analyzed complex conjugate pairs location real part complex roots indicates amount real time consumed mechanical energy drilling bits destroy formation rocks location imaginary roots indicates amount wasted mechanical energy due bit wear effect hydraulic energy drilling performance simulated using closed loop transfer function allows monitoring wasted mechanical energy wasted hours bit life consumed extra cutting due insufficient hydraulic energy results show visual representation poles location allows real time monitoring performance transferred mechanical energy due bit dullness insufficient hydraulic energy explicitly results also show high decline rate transferred mechanical energy always occurs within small values bit dullness compared occurred large values bit dullness confirm real field observations comparison field examples proves model reliability predicting drilling performance
whether metabolic syndrome mets components risk factors atopic dermatitis remains unclear study investigated association mets korean adults nationally representative data korean adults aged years cross sectional korea national health nutrition examination survey analysed female patients associated mets increased triglyceride level adjusting confounding factors odds ratio female participants mets central obesity waist circumference hypertriglyceridaemia large scale nationwide study korean adults mets components central obesity hypertriglyceridaemia correlated positively presence women
paper proposes new type curve elliptical roulette initially applies rotary lobe pumps new rotor profile mathematically modeled using principle gearing equations derived assess presence absence undercutting tooth profile effect new profile properties pumping performance evaluated using specially developed three dimensional fluid analysis model proposed curve tested using six novel rotor profiles based elliptical axial ratio parameter lambda shorter axis divided larger axis six new cases traditional case analyzed volume clearance conditions differences compared results show smaller elliptical axial ratio design produces better flow characteristics particular elliptical axial ratio smaller achieves high discharge efficiency allows vibration noise controlled flow rate fluctuation coefficient approximates traditional indicator proposed curve thus serve useful reference pump rotary fluid machine design elsevier ltd rights reserved
always computing intensive time consuming extract polygons massive classified images although parallel computing improve efficiency geographical data processing performance conversion suffers trade data decomposition result stitching paper present adaptable parallel strategy accelerates conversion process multi core cluster strategy improves method data decomposition optimizes task scheduling strategy adaptable decomposition method used partition raster data according data complexity raster dataset computing capability computing nodes moreover hierarchical task scheduling optimizes task allocation load balance among computing nodes procedure parallel conversion stitching implemented parallel algorithms based boundary linking algorithm using adaptable parallel strategy compared performance performances conventional parallel strategies results show processing time experimental raster data reduced desirable speedup maximal value achieved copyright john wiley sons ltd
background despite increasing knowledge prevalence borderline personality disorder bpd general population rising awareness mental disorders categorical dimensional construct research still lacking prevalence number bpd symptoms associated consequences comorbidity disability use mental health services general population methods data obtained second wave netherlands mental health survey incidence study nationally representative face face survey general population bpd symptoms measured means questions international personality disorder examination comorbidity common mental disorders assessed composite international diagnostic interview version results total population studied reported bpd symptoms symptoms symptoms bpd symptoms number bpd symptoms reported found positively associated living partner paid job comorbid mood anxiety substance use disorder turned uniquely associated disability also showed positive relationship using services dealing mental health problems although relationship strongly affected presence comorbid disorders conclusions even relatively low number bpd symptoms appears associated psychiatric comorbidity functional disability full blown bpd also subthreshold levels bpd symptoms need identified clinical practice research
elliptic curve cryptography used public key cryptosystem encryption decryption way one encrypt message attempt map message distinct point elliptic curve modifying message using mapping algorithm although arithmetic involved elliptic curve cryptography computationally less complex cryptographic algorithms conversion simple messages points elliptic curve always challenging paper discuss different schemes message mapping elliptic curve cryptosystem flaws method vulnerable cryptanalysis also derive guidelines good message mapping scheme elliptic curve cryptosystem later part paper discuss new mapping scheme resistible frequency analysis forms cryptanalysis copyright john wiley sons ltd
objective study identified prevalence relationship mood disorders multimorbidity middle aged older veterans method cross sectional data obtained veterans received primary care services pittsburgh healthcare system january december results veterans three organ systems chronic disease depressive disorder anxiety disorder occurring depression anxiety odds mood disorder increased additional organ system chronic disease odds greatest organ systems chronic disease younger age female gender non married marital status service connected disability also significant predictors mood disorder discussion findings suggest need integrate mental health assessment treatment chronic health care management veterans
background women using veterans health administration vha emergency departments eds yet vha capacities meet needs women unknown objective assessed vha resources processes conditions specific common women veterans design subjects cross sectional questionnaire census vha directors main measures resources processes place gynecologic obstetric sexual assault mental health care well patient privacy features stratified characteristics key results vha eds completed questionnaire approximately nine ten eds reported gynecologic examination tables within eds access specula gonorrhea chlamydia dna probes eds reported access pregnancy testing fewer two fifths eds reported radiologist review pelvic ultrasound images available one third reported emergent consultations gynecologists available written transfer policies specific gynecologic obstetric emergencies reported available fewer half eds eds reported emergency contraception however approximately half reported rho immunoglobulin available templated triage notes standing orders relevant gynecologic conditions reported uncommon consistent vha policy eds reported obtaining care victims sexual assault transferring another institution eds reported access private medical mental health rooms resources processes found available eds encounters women staffed beds located complex facilities metropolitan areas conclusions although vha eds resources processes needed delivering emergency care women veterans gaps exist studies non eds required comparison creative solutions needed ensure women presenting vha eds receive efficient timely consistently high quality care society general internal medicine
background myocardial native measurements likely influenced intramyocardial blood since blood variable longer compared myocardial degrade precision myocardial measurements precision could improved correction amount correction optimal blood variables correct unknown hypothesized appropriate correction would reduce standard deviation native myocardial methods consecutive patients referred cmr known suspected heart disease split derivation cohort model construction age years male validation cohort assessing model performance age years male exclusion criteria included focal septal abnormalities modified look locker inversion recovery sequence molli siemens aera used acquire maps maps used measure native myocardial blood multivariate linear regression correction model implemented using blood measurement hematocrit correction model derivation cohort applied validation cohort assessed reduction variability test results blood mean mean hematocrit correlated myocardial pearson range derivation validation cohorts respectively suggesting myocardial measurements influenced intramyocardial blood mean myocardial native differ derivation validation cohorts respectively derivation cohort correction using blood mean mean yielded decrease myocardial model derivation cohort applied validation cohort reduction maintained reduction measurement variability leads reduction sample size detect difference native myocardial conclusions correcting native myocardial blood improves precision myocardial measurement similar could consequently improve disease detection reduce sample size needs clinical research
waste generated natural resources recycled useful materials research produced acoustical waffle panel material useful absorber noisy housing acoustical waffle panels made hydraulic hot press machine purpose discussion describe machine design process compare waffle panels made coconut fiber wood sawdust best acoustic performances result hydraulic hot press machine structural strength stability load hot press machine safe transverse tensile stress longitudinal tensile stress smaller allowable stress steel material also highest sound transmission loss stl value
cryptococcosis opportunistic invasive fungal infection well described easily recognised occurs meningitis hiv infected persons malignancy treatment may also confer higher risk infection cryptococcus neoformans association well described case cryptococcosis cancer patient presented cases coincident neoformans infection malignancy adults published literature english reviewed data cases aggregated order describe demographics type malignancy site infection clinical manifestations treatment outcomes cryptococcosis patients cancer haematologic malignancies accounted cases lymphomas represented compared population data respectively cryptococcosis reported rarely patients solid tumours haematologic malignancy patients likely central nervous system disseminated disease receive amphotericin part initial therapy higher reported mortality rates solid tumours providers heightened awareness possibility cryptococcosis patients haematologic malignancy presenting infection
video games continuously growing popularity number users academic community shown increasing interest potential innovative teaching tools typical games contain tasks players must complete repetitively order advance later levels yet somehow manage keep constantly motivated enjoyable engagement achieved using number interlocking techniques effectively hide repetitive complex tasks presenting series smaller challenges embedded reward system learning occurs use seamless combination motor high level problem solving skills rapid feedback individual problem resolution cycles range split second decisions hours days matching reward systems used maintain player interest throughout cycles ensuring always new reward reach yet still obtainable relatively minor additional effort result players propelled entire experience pace matched abilities based well tested methods gaming industry educators trying instil motivational power video games learning process following practice known gamification used education gamification incorporates gaming elements non game processes order aid learning information retention however application classroom challenging since attempts generally limited implementing points achievement badges leader boards existing course material rewards potentially undermine intrinsic sense satisfaction engaging creative productive work generate however used well game elements reinforce intrinsic satisfaction rewards instead replacing quasi experimental study employed classroom version game show wants millionaire improve delivery undergraduate programming course assess gamification impacted learning experience empirical data student satisfaction performance gamified group compared control group followed traditional didactic methods despite fact sample size relatively small results promising showing significant increases class attendance final grades moreover students participating gamified cohort considered learning experience engaging motivating thus encouraging adoption technique courses
materials engineering database relevant fusion irradiation poorly populated long recognized fusion spectrum neutron source required facility ifmif present proposal evaluation regulatory approach proposed demo device shows purpose source changed lifetime equivalent irradiation exposure data generation lower levels exposure adopting defence depth strategy regular component surveillance reduces specification source respect ifmif allowing lower risk technology solutions considered description source facility fusion neutron irradiation research fafnir presented along project timescales costs euratom ccfe fusion association published elsevier rights reserved
background genomic interaction studies use next generation sequencing ngs examine interactions two loci genome subsequent bioinformatics analyses typically including annotation intersection merging data multiple experiments many file types analysis tools exist storing manipulating single locus ngs data currently file standard analysis tool suite manipulating storing pairedgenomic loci data type resulting genomic interaction studies genomic interaction sequencing data becoming prevalent standard file format tools working data conveniently efficiently needed results article details file standard novel software tool suite working paired genomic loci data present paired genomic loci pgl file standard genomic interactions data accompanying analysis tool suite pgltools cross platform pypy compatible python package available easy use unix package python module integration pipelines paired genomic loci analyses conclusions pgltools freely available open source tool suite manipulating paired genomic loci data source code depth manual tutorial available publicly www github com billgreenwald pgltools python module operations installed pypi via pygltools module
paper proposes design novel weighted rotor energy harvester oscillates due periodic change tangential component gravity harvest kinetic energy rotating wheel unlike traditional energy harvesting devices fixed natural frequency speed car increases centripetal acceleration rotating wheel also increases rotor natural frequency oscillation employing suitably designed weight natural frequency rotor match rotating frequency wheel speed rotor oscillates large angle angular velocity generate large amount power models power generation derived using faraday law induction lorentz force law followed numerical simulation performed verify correctness experiments output voltage power discussed considering constant accelerating plate rotation speed ohm resistor connected series average output power micro watts plate rotation speed rpm possible power source tpms
development manufacturing gear pairs determined system combining kinematic basis relative motions workpiece tool necessary production technology system unites two subsystems theory technology via multitude parameters gears assigned different classes according range existence paper describes mathematical model determining range existence general kinematic scheme gear shaping model based analysis existing kinematic schemes theoretical real shaping based morphological approach individual kinematic shaping schemes classified mathematical models developed shaping schemes well necessary translational rotational motion matrices exemplarily presented gear manufacturing machine using shaping principle modern approaches principles designing equipment instrumentation systems gear manufacturing presented methodical basics selecting optimal machine configuration depending technical economic requirements machining form gear tooth profile stated system theoretical technological optimization synthesis instrumentation systems gear manufacturing presented
propose short reliable instrument based pre existing items measuring three dimensions religion end means quest starting items originally included religious orientation scale ros allport ross religious life inventory rli batson schoenrade ventis performed four steps analyses involving three independent samples italian catholic respondents total process progressive refinement using exploratory factor analyses investigation meaning items confirmatory factor analyses eventually selected items pre existing scales recombined religious life orientation scale report initial evidence psychometric qualities proposed instrument analyze correspondence parent scales future research investigate properties scale respondents countries belonging religions
effectively exploring browsing document collections fundamental problem visualization traditionally document visualization based data model represents document set comprised words effectively characterizing document paper take alternative perspective motivated manner users search documents research process aim visualize documents via usage documents tend used present new visualization scheme citevec allows user dynamically explore browse documents via documents use information capture citation contexts document collection starting usage oriented word document projection user dynamically steer document projections prescribing semantic concepts form phrase document compositions document phrase analogies enabling exploration comparison documents use user interactions enabled joint representation words documents common high dimensional embedding space user specified concepts correspond linear operations word document vectors case studies centered around large document corpus computer vision research papers highlight potential usage based document visualization
usage active compounds dietary phytochemicals prevention induced skin diseases increasingly gaining attention development skin care products purpose study measure influence delphinidin botanical agent cell mechanical properties evaluated atomic force microscopy afm technique immortalized human keratinocyte cell line hacat exposed uvb radiation cells treated various doses uvb radiation without pre post treatment selected concentrations delphinidin measurements elastic properties revealed exposure hacat cells high dose uvb radiation caused decrease cell elastic modulus accompanied decrease metabolic activity rearrangement actin cytoskeleton disappearance cell repair marker pre treatment post treatment delphinidin non cytotoxic concentrations restored elastic modulus irradiated keratinocytes direct afm analysis showed uvb mediated decrease cell stiffness restored effectively cells treated delphinidin uvb irradiation results demonstrate regenerative effect delphinidin mechanical properties cells exposed uvb radiation may due antioxidant inhibitory effect matrix metalloproteinases activation elsevier rights reserved
role cells graft rejection tolerance aroused great interest previously reported rituximab rit induction prior kidney transplantation ktx reduced incidence rate chronic rejection performed cross sectional investigation determine characteristics cells rit induction ktx sampled blood patients without rit induction months ktx rit group majority repopulating cells transitional type memory cells scarce although transitional cells believed immune regulatory functions producing transcriptional levels peripheral blood mononuclear cells similar groups contrast transcription levels baff receptor relatively increased patients rit induction conclusion baff receptor expressing highly proliferating transitional cell major subset rit induction ktx
work presents novel mixed signal control scheme boost power factor correction pfc rectifier digital controller modulates inductor peak current produce low distortion line current discontinuous conduction mode dcm continuous conduction mode ccm without need average current sensing lookup table lut optimizes efficiency low input currents allowing operation khz dcm based calculated thresholds high input currents converter operates mhz ccm reduced inductor footprint analog time generator digital frequency locked loop facilitates ccm operation eliminating need slope compensation current loop reduces frequency variations lut programmed adaptive output voltage low highmains line voltage vrms optimize efficiency broad range conditions pfc prototype operates mhz peak efficiency total harmonic distortion
cooperative spectrum sensing despite effectiveness enabling dynamic spectrum access suffers location privacy threats merely secondary users sus sensing reports need shared fusion center make spectrum availability decisions highly correlated users locations therefore important cooperative spectrum sensing schemes empowered privacy preserving capabilities provide sus incentives participating sensing task paper propose privacy preserving protocols make use various cryptographic mechanisms preserve location privacy sus performing reliable efficient spectrum sensing also present cost performance tradeoffs first consists using additional architectural entity benefit incurring lower computation overhead relying symmetric cryptography second consists using additional secure comparison protocol benefit incurring lesser architectural cost requiring extra entities schemes also adapt case malicious fusion center discuss paper also show proposed schemes secure efficient existing alternatives also achieve fault tolerance robust sporadic network topological changes
lorenz system investigate multiple hopf bifurcation centerfocus problem equilibria applying method symbolic computation obtain first three singular point quantities proven lorenz system generate small limit cycles two symmetric equilibria furthermore center conditions found weak foci highest order proved third thus obtain small limit cycles symmetric equilibria via hopf bifurcation time realize also though related three dimensional chaotic systems lorenz system differs hopf bifurcation greatly chen system system elsevier inc rights reserved
digital audio signal provides large capacity embedding hidden messages using digital steganography techniques prevent hazardous steganography embedding internet becomes important task field network security internet environment steganography attack method required generic real time active warden based attack method potential generic method steganography attack discrete spring transform dst based generic active warden steganography attack framework proposed paper based dst real time steganography attack method proposed potential unauthorized hidden message removed real time manner uploading downloading audio signal real time signal perceptual quality control achieved automatic feedback objective audio quality evaluation model attack parameters adaptively changed reach balance attack performance audio signal quality simulation results validate proposed method terms steganography attack performance audio signal quality attack copyright john wiley sons ltd
implementation virtual practices complement traditional practices turned efficient tool solve classical problems occurring teaching technological subjects manufacture engineering field current work integration virtual practice sets analysed means unified platform extra contribution previous developments generating manufacturing virtual laboratory department manufacturing engineering university malaga
purpose descriptive study examines hypertension diagnostic practices utah primary care clinics relative preventive services task force uspstf recommendations accurate diagnosis hypertension assessed clinic procedures place facilitate accurate office outof office blood pressure measurement methods online questionnaire administered primary care clinics compared current clinic measurement practices usptf recommendations assessed level adherence recommendations level clinic integration hospital results primary care clinics received assessment completed questionnaire clinics varied significantly ability provide accurate office measurement ranging clinics complying uspstf recommendations clinics reported access ambulatory monitoring instructional materials accurate home monitoring clinics integrated hospital likely report adherence recommendations solo independent clinics conclusion assessment shows many primary care clinics well prepared implement uspstf guidelines accurate diagnosis hypertension office practices benefit support develop capacities
wireless sensor network represents distributed environment consists sensors actuators monitor control real world objects devices web services service oriented architecture fundamental elements provide demand applications integration business processes wireless sensor network service oriented architecture result better alignment enterprise applications article uses multiple domain matrix extensions called business process model notation multiple domain matrix analyze structures relations among processes modeled business process model notation wireless sensor network elements services applying organization activity multiple domain matrix partitioning algorithm different organizations coupled activities cyclic relations identified provide process structure information matrix perspective promote business process analysis optimization partitioning analysis results used form initial software architecture includes subsystems packages architecture centric software engineering practice applied help development wireless sensor network applications two process examples wireless sensor network applications used analyzed illustration validation purposes
use information communication technologies icts developing regions gained momentum due increasing affordability particularly rural areas ict infrastructures information management often non existent giving potential technology users opportunity actively engage contribute design artefact increases adoption sustainable use paper illustrate application community based codesign cbcd led development ict intervention support water management three rural communities uganda community based system helps water managers track water users payments expenditures bid improve transparency accountability trust present research learnings method engagement rural communities improved use intermediaries paying attention community values well exercising ethics reciprocity community based ict initiatives
recently bernard gervais allen campomizzi klein reported individuals less able recognize inverted upright pictures sexualized men compared women based formulation sexualized body inversion hypothesis sbih concluded sexualized women compared men perceived object like manner supporting sexual objectification females independent observer gender challenge interpretation hypothesize originally reported effect result methodological artifact due gender symmetry stimuli setup symmetry confounds original stimulus set tested theoretically parsimonious account methodologically stricter extended conceptual replication putative effect results two studies showed original stimulus set indeed suffered symmetry confounds necessary boundary conditions order hypothetical effect occur concluded sbih postulated bernard based methodological artifact related symmetry detection elsevier rights reserved
research ambient assisted living aal strives ease daily lives people disabilities chronic medical conditions aal systems typically consist multitudes sensors embedded devices generating large amounts medical ambient data however biomedical sensors lack processing power perform key monitoring data aggregation tasks necessitating data transmission computation central locations focus development scalable context aware framework easing flow data collection data processing resource constrained nature typical wearable body sensors factored proposed model cloud computing features utilized provide real time assisted living service myriad distributed aal systems play unique requirements eccentricities challenge lies need service disparate systems middleware layer coherent flexible significant complexity management sensor data derivation contextual information well monitoring user activities locating appropriate situational services proposed cocamaal model seeks address issues implement service oriented architecture soa unified context generation done efficiently aggregating raw sensor data timely selection appropriate services using context management system cms unified model includes patients devices computational servers single virtual community aal services enhanced prototyped proposed model implemented case studies demonstrate effectiveness elsevier rights reserved
context enormous number papers published area software engineering since inception better characterize understand massive research literature need comprehensive bibliometrics assessments vibrant field objective objective study utilize automated citation topic analysis characterize software engineering research literature years bibliometrics studies appeared field article aims comprehensive bibliometrics assessments vibrant field method achieve objective report paper bibliometrics study data collected scopus database consisting articles thematic analysis used topic modeling automatically generate probable topic distributions given data results found number papers published per year grown tremendously currently papers published every year time nearly half papers cited using text mining articles titles found currently hot research topics software engineering web services mobile cloud computing industrial case studies source code test generation finally found small share large countries produce majority papers small european countries proportionally active area based number papers conclusion due large volumes research suggest using automated analysis bibliometrics done paper picking cited papers present land marks thematic analysis characterize entire field useful students new comers presenting achievements disciplines particular see report value analysis situations performing full scale slr feasible due restrictions time lack exact research questions elsevier inc rights reserved
paper develops robust controller pitching plunging airfoil using state space representation theodorsen lift model employing linear matrix inequalities method parameter uncertainty input disturbances considered model existence condition robust state feedback controller obtained using lyapunov functional approach practical systems difficult obtain states model needed controller thus observer existence condition proposed provide states information model several examples used demonstrate effectiveness designed controller designed observer
study examined developmental trajectory potential source resilience prosocial behaviors children peer victimization third sixth grade trajectories examined children females caucasian phase nichd study early child care latent growth mixture modeling indicated three latent classes emerged labeled resilient risk normative follow analyses covariates supported presence classes resilient class particular interest study indicated high initial dramatically decreasing victimization coupled high stable prosocial behaviors year period findings suggest potential protective function engaging prosocial behaviors victims highlight need examine potential heterogeneity among victims elsevier inc rights reserved
aim given ubiquitous nature hangover experience among drinkers study aimed profile hangover experience terms number patterns past year symptoms methods current drinkers canada recruited zoompanel asked past year hangover symptoms explored correlation alcohol consumption problems treatment factors findings increased number symptoms associated higher alcohol use disorders identification test audit problem score perceived harm drinking younger age flushing blushing drinking mean symptoms four patterns found latent class analysis class symptoms class thirst tiredness headache nausea vomiting class thirst tiredness headache class wide range class characterised blushing drinking higher perceived harm attempts reduce drinking due hangovers classes associated heavier consumption class compared class lower drinking refusal self efficacy conclusions higher alcohol consumption lower drinking refusal self efficacy relate symptoms however group variable alcohol consumption experience hangovers link problems treatment hangover clear patterns symptoms symptom severity may worth investigation
aims evaluate pulmonary vasculopathy autopsy series patients combined pulmonary fibrosis emphysema cpfe compare findings patients idiopathic pulmonary fibrosis ipf alone emphysema alone methods results retrospectively analysed clinical radiological pathological features patients cpfe ipf emphysema evaluated pulmonary vascular venous venular arteriolar tissue changes fibrotic emphysematous relatively unaffected preserved areas using heath edwards scoring system found moderate severe vasculopathy cpfe group significant differences fibrotic emphysematous areas among three groups however preserved area grading significantly different among three groups vasculopathy cpfe group severe although venous venular arteriolar changes almost fibrotic emphysematous areas three groups showed significant differences significant differences venous venular arteriolar changes preserved area among three groups prevalent cpfe group cpfe group venous venular changes vasculopathy heath edwards grading highest fibrotic area lowest preserved area conclusions results imply pulmonary vasculopathy patients cpfe could occur whole lung tissue may explain tendency lead development pulmonary hypertension cpfe cases
objectiveto evaluate associations binge eating disorder bed somatic illnesses determine whether medical comorbidities common individuals present bed comorbid obesity methodcases individuals bed diagnosis swedish eating disorders quality registers ten community controls matched case sex year month county birth associations bed status neurologic immune respiratory gastrointestinal skin musculoskeletal genitourinary circulatory endocrine system diseases evaluated using conditional logistic regression models examined associations adjusting lifetime psychiatric comorbidity amongst individuals bed explored whether comorbid obesity associated risk somatic disorders resultsbed associated classes diseases evaluated strongest associations diabetes odds ratio confidence interval circulatory systems likely indexing components metabolic syndrome amongst individuals bed comorbid obesity likely lifetime history respiratory gastrointestinal diseases without comorbid obesity increased risk somatic disease classes individuals bed simply due obesity lifetime psychiatric comorbidity discussionthe association bed many somatic illnesses highlights morbidity experienced individuals bed clinicians treating patients bed vigilant medical comorbidities nonpsychiatric providers may first clinical contact bed underscoring importance screening primary care authors international journal eating disorders published wiley periodicals inc int eat disord
computer programming competence good research field students computer science assisted intelligent tutoring system guide students learning process proposing corresponding learning activities particular student article outline proposal use elearning standard automatic assessment techniques build learning program addition show implemented system test proposal evaluated students university wiley periodicals inc comput appl eng educ view article online doi
recently identity based quadratic exponentiation randomized cryptosystem scheme using discrete logarithm problem integer factorization problem developed contribution lies initiated idea create identity based cryptographic scheme without bilinear pair scheme achieve security goal protecting data prevent adversary snooping encrypted data finding secrete keys paper proposed modification setup phase using floor function super increasing sequence modified encryption decryption process identity based quadratic exponentiation randomized cryptographic scheme also discuss enhance security proposed scheme processing cost proposed scheme
paper generalized fractional modified korteweg vries fmkdv equation time dependent variable coefficients generalized model nonlinear lattice plasma physics ocean dynamics investigated aid simplified bilinear method fractional transforms symbolic computation corresponding soliton solutions given illustrated characteristic line method graphical analysis applied discuss solitonic propagation collision including bidirectional solitons elastic interactions finally resonance phenomenon equation examined
design super capacitor powered shape memory alloy sma actuated accumulator blowout preventer bop presented paper featured several advantages conventional hydraulic accumulators including instant large current drive quick system response elimination need pressure conduits however mechanical design introduced two challenges nonlinear nature sma actuators varying voltage provided super capacitor control system design cerebellar model articulation controller cmac feedforward plus pid controller developed aim compensation adverse effects experiments conducted scaled model experimental results show precision control achieved proposed configurations algorithms
objective study correlate patient driven tool routine assessment patient index data rapid common tools used daily practice measure disease activity rheumatoid arthritis one hundred nineteen patients according american college rheumatology criteria consecutively attended outpatient clinic august december evaluated data stored electronic form included demographic information comorbidities concomitant medication laboratory results disease activity determined tender swollen joint count pain disease activity visual analog scales vas disease activity score das clinical disease activity index cdai simplified disease activity index sdai multidimensional health assessment questionnaire mdhaq correlations rapid disease activity tools assessed mean age years median disease duration years iqr females median scores mdhaq iqr das iqr rapid iqr strong correlation obtained rapid das cdai sdai rapid high correlation tools regularly used disease activity assessment patients daily practice ease application favors routine use require laboratory results joint counts
paper value working solution ionic polymer metal composite ipmc actuators systematically changed effect deformation behavior experimentally investigated ipmc actuators consist thin perfuorinated ionomer membrane electrodes plated surfaces undergo large bending motion small electric field applied across thickness direction lightness softness usableness wet conditions ipmc actuators promised used artificial muscles biomimetic actuators medical applications deformation properties ipmc actuators influenced working solutions however basic understandings effect value working solution deformation properties clarified yet therefore characteristics ipmc actuator evaluated paper ipmc actuators palladium electrodes used responses step voltage several solutions investigated results showed deformation behavior drastically changed acid alkali solutions acid solutions ipmc actuator showed relaxation motion though ipmc actuator alkali solutions kept deformed shape applying voltage
purpose software product management spm unites disciplines related product strategy planning development release many organizational activities addressing technical social market issues releasing software product owing high number activities involved spm remains complex discipline adopt purpose paper understand core supporting spm activities design methodology approach authors adopted research method meta ethnography present set techniques synthesizing individual qualitative studies increase degree conceptualization results obtained three empirical studies synthesized using meta ethnography approach enhance rethink create higher level abstraction findings findings results show study theoretical practical contribution meta ethnography synthesis widely applied software engineering authors illustrate use research method practice software engineering research practical contribution study identification five core six supporting spm activities originality value practical value paper identification core spm activities present company practicing spm list supporting spm consists activities reported product manager affect product success
objectives study compared behavioral weight loss program bwl stress management based program emotional brain training ebt weight loss blood pressure depression perceived stress diet physical activity methods subjects body mass index bmi recruited lexington kentucky january randomized bwl ebt week intervention recruited participants randomized ebt bwl randomization allocation group performed using spss software weight blood pressure depression perceived stress dietary intake physical activity measured baseline week week linear models change time fit calculate confidence intervals intervention effects results bwl produced greater changes bmi ebt ebt bwl improved bmi systolic blood pressure depression perceived stress bwl also improved diastolic blood pressure ebt maintained improvements bmi systolic blood pressure depression perceived stress bwl maintained improvements bmi depression conclusions bwl produced greater weight loss ebt however ebt produced sustained improvements stress depression systolic blood pressure combination two approaches explored elsevier inc rights reserved
background musculoskeletal injuries occur frequently elite athletes understanding professionals work patients sports injuries think prevention suggested important aspect improve effectiveness programs prevent sports injuries objectives describe characterize opinions physical therapists physicians trainers risk factors prevention injury elite athletes method qualitative study semi structured interviews members medical technical department brazilian delegation participated pan american games guadalajara interview conducted using two questions think cause injuries athletes participating sport prevent injuries sport interviews analyzed two stages identification thematic units followed categorization grouping thematic units results interviewed total professionals regarding question main factors attributed responsible injury training incorrect sports techniques regarding question main reported strategies used prevent injuries muscle strengthening nutritional counseling guidance conclusions main factors affecting appearance lesions training incorrect sports technique inadequate nutrition factors related athlete behavior main injury prevention strategies muscle strengthening nutritional counseling guidance
male female legislators different qualifications experience backgrounds main differences explains differences women likely rely personal connections well qualified women routinely passed favor similarly qualified men gender quotas transitions multiparty democracy affect recruitment patterns men women gender quotas lead recruitment less qualified women article attempts explain informal gendered selection norms change time using detailed data mexican senators since data provide evidence discrimination successful female senators need legislative experience party experience male senators also find evidence traditional gender roles lead women follow different paths power transition democracy implementation gender quotas importance local legislative experience increased discrimination female aspirants declined diverse group women entered senate data show women likely men rely personal connections get power
background hereditary angioedema hae rare serious condition characterized recurrent spontaneous attacks angioedema affecting superficial tissues upper respiratory gastrointestinal tracts potentially fatal disfiguring nature hae impacts health related quality life hrqol patients condition objectives assess health related quality life canadian patients hae using item short form health survey methods twenty one patients living canada age known diagnosis hereditary angioedema due inh deficiency hae completed generic hrqol questionnaire results compared canadian normative data converting scores scores results showed significant reduction general health patients hae compared healthy canadians percentage patients scores large effect general health subscale bodily pain vitality subscales physical component scores mean scores eight dimensions ranged mean physical mental component scores internal consistency evaluation demonstrated cronbach alpha value scales general perception health significantly different patients compared canadian normative data conclusions study canadian patients hae shows general health frequently affected followed bodily pain vitality measured offers valuable insight assess quality life patients hae however larger number canadian patients specific tools assessment needed better evaluation
current practice discrete time electricity pricing starts fall short providing accurate economic signal reflecting continuous time variations load generation schedule power systems paper introduces fundamental mathematical theory continuous time marginal electricity pricing first formulate continuous time unit commitment problem constrained variational problem subsequently define continuous time economic dispatch problem binary commitment variables fixed optimal values prove continuous time marginal electricity price equals lagrange multiplier variational power balance constraint continuous time problem proposed continuous time marginal price dependent incremental generation cost rate also incremental ramping cost rate units thus embedding ramping costs calculation marginal electricity price numerical results demonstrate continuous time marginal price manifests behavior constantly varying load generation schedule power systems
database structured collection records data stored computer consulted program answer queries records retrieved queries become information used make decisions database consists one tables containing records values fields pertain attributes object represented table relational databases contain multiple tables linked means key fields database management system computer program manages database queries data produce reports information examples simple databases produced described article
stealth technology great importance significance reducing radar cross section improving survivability target aircraft absorber one important structures stealth technology however present investigations absorbers mainly focus narrow band multi band extend operation bandwidth graphene based absorber structure proposed paper proposed absorber periodic structure whose unit cell consists square circular graphene based ring surface impedance periodic structure optimized match impedance free space wide band adjusting electrostatic bias voltage operation band significantly extended using commercial software cst microwave studio performance proposed absorber studied simulated results show proposed absorber absorb electromagnetic waves ultra wideband ghz absorbing rate moreover proposed absorber insensitive polarization incident wave due symmetry structure also find absorber tuned work frequency range ghz fixed geometrical parameter equivalent circuit model ecm approach interference theory inf employed investigate physical mechanism proposed absorber according ecm analyze resonant characteristics square circular graphene rings owing existence two different graphene rings two resonant frequencies detected optimizing structure parameters graphene rings two resonant frequencies brought closer resulting increase operation band hand real part input impedance equivalent circuit reaches omega imaginary part close omega provides good matching free space leading high absorption rate according interference theory amplitudes phases direct reflection multiple reflections waves studied found destructive interference direct reflection multiple reflection makes absorber high performance ultra wideband results obtained ecm inf good agreement simulation ones
background general health promoting campaigns often targeted people need web app based tools new way reach motivate help people poor health status objective aim study test web mobile app based tool sosu life employees social welfare health care sector denmark methods randomized controlled trial carried workplace intervention tool designed help users make healthy lifestyle changes losing weight exercise quit smoking team competition participating workplaces took place first weeks intervention twenty nursing homes elderly people municipalities denmark participated study employees nursing homes randomized either municipality level use sosu life tool serve control group intervention participants underwent baseline measurements including body weight waist circumference body fat percentage blood pressure blood cholesterol level filled questionnaire covering various aspects health participants measured weeks results total sosu life control participants included study weeks participants still study sosu life control participants completed week intervention sosu life control weeks sosu life group larger decrease body weight body fat percentage waist circumference compared control group conclusions sosu life web app based tool modest yet beneficial effect body weight body fat percentage health care sector staff
post traumatic stress disorder ptsd serious mental illness affects current former military service members disproportionately higher rate civilian population prior studies shown ptsd symptoms follow multiple trajectories civilians military personnel current study examines whether trajectories ptsd symptoms veterans separated military similar continuously serving military personnel millennium cohort study population based study military service members commenced follow assessments occurring approximately every years thereafter ptsd symptoms assessed time point using ptsd checklist latent growth mixture modeling used compare ptsd symptom trajectories personnel separated veterans personnel remained military service active duty four distinct classes resilient delayed onset improving elevated recovering described ptsd symptoms trajectories veterans active duty personnel trajectory shapes qualitatively similar active duty veterans hbwever within resilient improving elevated recovering classes shapes statistically different although low symptom class common groups veterans active duty veterans likely classified three classes cases shape trajectory highly similar two groups despite differences military civilian life authors published elsevier ltd
penn state worry questionnaire children pswq one frequently used instruments assess worry children current study examines measurement invariance pswq romanian sample participants recruited community clinical populations findings replicated good psychometric properties pswq short pswq original scale negative items deleted multigroup confirmatory factor analysis supported measurement invariance configural metric scalar across gender age clinical diagnosis convergent validity assessment measures also established finally implications use pswq assessment anxiety children adolescents discussed
purpose purpose paper explore different clinical features pathological demand avoidance pda antisocial personality disorder aspd presented form single case study study highlights potential misdiagnosis conceptual confusions practitioners forensic settings two conditions working offenders personality disorders design methodology approach case formulation using five method based personal history incarcerated male presented clinical similarities differences pda aspd delineated differences similarities evaluated applied offender management including intervention options findings considerable similarities aspd pda making two conditions difficult separate diagnostic criteria identify childhood behavioural problems aggression destructiveness conduct disorder manipulation non compliance indications disorder example criteria later adult aspd presence childhood antisocial behaviour however behaviours may also suggestive attention deficit hyperactivity disorder non compliance part pda violent behaviours aggression also perceived similar way misdiagnosis pda aspd reduces efficiency treatment programmes originality value implications findings could prove useful successful risk management offenders pda given similar behavioural characteristics pda aspd prevalence pda among offenders may higher observed aim study raise awareness potential conceptual complications clinical confusions two conditions view aid offender management case formulation large scale study offenders pda would draw attention prevalence condition well association offending behaviour
advances technology frequent pattern mining used widely daily lives using technology one obtain interesting useful information would help one make decisions apply judgment example marketplace managers mine transaction data obtain information help improve services understand customer buying habits determine suitable scheme placement goods increase profits medical biotechnology applications however rate data generated rapid leading problems caused big data therefore many researchers studied distributed parallel cloud computing technology select best among however data mining uses multiple computing nodes requires transmission considerable amount data network environment available network bandwidth limited many different tasks transmitted time many servers working network segment results poor transmission causing severe transfer delay either internal external network thus propose fast distributed mining algorithm discovering frequent patterns congested networks fdmcn algorithm based carm main purpose reduce tree transmission portion information required mining using computing nodes results empirical evaluation various simulation conditions show proposed method fdmcn delivers excellent performance terms execution efficiency scalability compared psws algorithm
background incidence invasive fungal disease ifd increasing worldwide past two three decades critically ill patients intensive care units vulnerable fungal infection early detection treatment important decrease morbidity mortality critically ill patients objective study aimed assess factors associated early ifd critically ill patients materials methods prospective cohort study conducted critically ill patients march september total number patients study drawn based one risk factors human immunodeficiency virus specimens collected day hospitalization multivariate analysis logistic regression performed factors bivariate analysis results two hundred six patients enrolled study seventy four patients ifd majority males mean age years range mean leon score score range majority group nonsurgical nontrauma mean fungal isolation positive day candida frquently isolated fungal infection urine culture yielded highest number fungal isolates mortality rate study multivariate analysis diabetes mellitus odds ratio confidence interval found independent factor associated early ifd critically ill patients conclusion significant factor incidence early ifd critically ill patients
childhood maltreatment strongly associated depression characterized reduced reactivity reward identifying factors mitigate risk depression maltreated children important understanding etiological links maltreatment depression well improving early intervention prevention examine whether high reward reactivity behavioral neurobiological levels marker resilience depressive symptomology adolescence following childhood maltreatment sample adolescents history maltreatment mean age years completed fmri task involving passive viewing emotional stimuli bold signal changes positive relative neutral images extracted basal ganglia regions interest participants also completed behavioral reward processing task outside scanner depression symptoms assessed time mri years later greater reward reactivity across behavioral neurobiological measures moderated association maltreatment baseline depression specifically faster reaction time cues paired monetary reward relative unpaired reward greater bold signal left pallidum associated lower depression symptoms maltreated youth longitudinally greater bold signal left putamen moderated change depression scores time higher levels reward response associated lower increases depression time among maltreated youths reactivity monetary reward positive social images behavioral neurobiological levels potential marker resilience depression among adolescents exposed maltreatment findings add growing body work highlighting individual differences reactivity reward core neurodevelopmental mechanism etiology depression
background working memory training wmt shown offer therapeutic benefits patients attention deficit hyperactivity disorder adhd patients mild borderline intellectual disabilities mbid however robust evidence transfer effects treatment benefits wmt placebo training lacking owing nature double blind research designs rcts children received non specific coaching based actual training performance active coaching based individual training results clinical practice might enhance efficacy cogmed wmt furthermore clinical experience general treatment approach vulnerable children shown intensity duration wmt often stressful study therefore investigated efficacy less intensive prolonged cogmed wmt including active personalized coaching feedback reducing behavioral symptoms improving neurocognitive functioning academic achievements children mbid neuropsychiatric disorders methods design double blind rct children age neuropsychiatric disorders adhd autism spectrum disorder asd mbid two groups receive cogmed wmt version home school weeks days week min day one group receive active personalized coaching feedback based actual individual performance cogmed training group receive general non personalized coaching receive personalized coaching feedback groups undergo neurocognitive assessment working memory executive functioning academic achievements training complete several questionnaires behavioral problems parenting style months follow discussion study add literature since role coaching cogmed wmt studied also provide opportunities investigate alternative version wmt large group vulnerable children evidence based treatments available ultimately allow advise mental health care professionals special education schools use type intervention children mbid neuropsychiatric disorders
home energy management system hems essential residential electricity consumers participate actively demand response programs dynamic pricing schemes sufficiently effective end users without utilizing hems consumption management paper intelligent hems algorithm proposed schedule consumption controllable appliances smart household electric vehicle electric water heater ewh incorporated hems controllable appliances storage capability evs flexible energy intensive loads provide advantages dispatchable source expected penetration evs grow considerably future algorithm designed smart household rooftop photovoltaic system integrated energy storage system ess simulation results presented different pricing programs demonstrate application hems verify effectiveness case studies conducted using real measurements consider household load rooftop generation forecast built parameters controllable appliances inputs results exhibit daily household energy cost reduces using proposed optimization based algorithm hems instead simple rule based algorithm different pricing schemes elsevier rights reserved
applications advanced control algorithms important refrigeration field achieve low energy costs accurate set point tracking however designing tuning control systems depend dynamic mathematical models approaches like analytical modeling time consuming usually lead large number differential equations unknown parameters work application system identification fast recursive orthogonal least square frols algorithm proposed alternative analytical modeling develop process dynamic model evaporating temperature evt condensing temperature cdt useful superheat ush outputs interest system covariance analysis candidate inputs shows model single input single output siso good simulation results obtained two different validation data average output errors evt model cdt model ush model one datasets showing algorithm valid alternative modeling refrigeration systems
objective examine dynamic relationship treatment expectations treatment outcome course clinical trial winter seasonal affective disorder sad method currently depressed adults major depression recurrent seasonal pattern randomized weeks group delivered cognitive behavioral therapy sad cbt sad light therapy majority female white mean age years treatment expectations cbt sad assessed using modification treatment expectancy credibility survey borkovec nau depression severity assessed using beck depression inventory second edition beck steer brown measures administered pretreatment midtreatment posttreatment results treatment progressed expectations treatment received increased across time steeply cbt sad patients moderately patients collapsing across time patients higher treatment expectations lower depression severity lower treatment expectations cross lagged panel path analysis significant effect treatment expectations midtreatment depression severity posttreatment among cbt sad patients conclusions treatment expectations changed across treatment affected outcome assessed monitored repeatedly throughout treatment findings suggest treatment expectations midtreatment mechanism cbt sad reduces depression replicated sad samples examined generalizability nonseasonal depression findings underscore importance research examining treatment expectations mediating cbt effects depression types psychopathology
factors related endocrine changes hormone substitution treatment pre post operation periods craniopharyngioma cases examined twenty patients underwent tumor resection january january included study monitored factors related endocrine changes hormone substitution treatment pre post operation periods blood thyroid stimulating hormone triiodothyronine thyroxine prolactin follicle stimulating hormone luteinizing hormone cortisol levels measured patients urinary volume urine specific gravity also measured operation operation observed diabetes insipidus decrease tsh gonadal hormone levels frequently compared pre operation however incidence high prolactin markedly reduced following surgery number hypothyroidism cases surgery statistical significance conclusion surgery craniopharyngioma aggravated endocrine dysfunction craniotomy total tumor resection considerable effects endocrine system routine hormone therapy alternative treatment necessary operation alternative treatment adrenal cortex hormones reduced incidence low blood cortisol
design performance mechatronic systems depends many factors subsystems like gears hydraulic components electric motors latter considered principle device electromechanical power conversion thus design becomes prime importance paper aims build electric motor models along control strategy power electronics component order study impact temperature rise critical areas motor mechatronic systems paper focuses constructing detailed thermal network permanent magnet synchronous machine comparing experimental results order evaluate accuracy model along electromechanical model machine power converter control strategy integrated simulated amesim advanced software environment simulating mechatronic systems
autofocusing feature detection two essential processes performing automated biological cell manipulation tasks paper introduced technique capable focusing holding pipette mammalian cell bright field microscope automatically technique detect track presence orientation polar body oocyte rotated tip micropipette algorithms evaluated using mouse oocytes experimental results show algorithms achieve high success rates robust accurate image processing methods widely applied perform various automated biological cell manipulations
seasonal depression seriously diminishes quality life many patients improve condition propose luxamet bright light therapy system system potential relieve patients symptoms caused seasonal depression system designed formal model driven design methodology methodology enabled minimize systemic hazards like blinding patients unhealthy dose light achieved controlling race conditions memory leaks design time prove system specification deadlock well livelock free invariant violations proofs together similarity specification model implementation code make confident implemented system reliable tool help patients seasonal depression
although considerable progress made identifying genes regulating accumulation hormones involved leaf senescence studies focused natural variations jasmonates content much less underlying genetic basis moreover epigenetic regulation jasmonate mediated leaf senescence remains largely unknown study carried metabolic profiling worldwide collection rice accessions demonstrated substantial variations jasmonate levels among accessions subsequent metabolite based genome wide association study identified candidates two major quantitative genes qtgs ospme ostsd affecting content jasmonates investigations using series relevant mutants transgenic lines revealed meoh jasmonate cascade plays important role regulating leaf senescence moreover showed ossrt one two sir silent information regulator homologs rice negatively regulates leaf senescence repressing expression biosynthetic genes metabolic cascade least particially histone deacetylation ospme taken together results indicate meoh jasmonates cascade epigenetic regulation crucial controlling leaf senescence process rice
paper presents evolutionary optimal fuzzy system information fusion heterogeneous distributed computing polar space dynamic model online motion control swedish redundant robots intelligent fuzzy system incorporated parallel metaheuristic bacteria foraging optimization bfo artificial immune system ais called pbfoais field programmable gate array fpga realization optimal polar space online motion control four wheeled redundant mobile robots hybrid paradigm gains benefits taguchi quality method bfo ais distributed processing fpga technique experimental results conducted present effective optimization high accuracy proposed fpga based pbfoais tracking controller finally comparative works provided demonstrate superiority fpga based pbfoais polar space redundant controller conventional control methods
qualitative exploratory study objective identifying perceptions practices among health professionals angola concerning intimate partner violence women semi structured interviews held senior health administrator head nurses medical directors psychologists nurse technicians three national hospitals capital city luanda perceptions angolan health professionals towards violence women marked cultural construction woman social role family belief male superiority female weakness despite familiarity types violence consequences physical mental health health professionals practices providing care women situations violence focus treatment physical injuries overlooking subjectivity complexity situations recent inclusion issue public policies reflected health professionals practices raises challenges health sector caring women situations violence
meniscal cartilage tears common predispose osteoarthritis occur avascular portion meniscus current repair techniques usually fail described previously use undifferentiated autologous mesenchymal stem cells mscs seeded onto collagen scaffold msc collagen scaffold integrate meniscal tissues vitro objective translate method cell therapy patients torn meniscus long term goal delaying preventing onset vitro optimization tested ovine msc collagen scaffold sheep meniscal cartilage tear model promising results weeks although repair sustained months conducted single center prospective open label first human safety study patients avascular meniscal tear autologous mscs isolated iliac crest bone marrow biopsy expanded seeded collagen scaffold resulting human msc collagen scaffold implant placed meniscal tear prior repair vertical mattress sutures patients followed years five patients treated significant clinical improvement repeated measures analysis three asymptomatic months magnetic resonance imaging evidence recurrent tear clinical improvement knee function scores two required subsequent meniscectomy due retear nonhealing meniscal tear approximately months implantation adverse events occurred conclude undifferentiated mscs could provide safe way augment avascular meniscal repair patients
much concern perceived increase sexualised media potential impact children well development phenomenon examined four phase study focusing specifically music media phase investigated prevalence sexualised music media broadcast australian free air television child friendly time periods phase examined children preferred music genres artists videos assess engagement sexualised music media phase examined children perceptions gender roles self identities phase explored children imitations music media artists performances study used mixed method approach incorporating content analysis individual group interviews children activities observations findings reveal music media substantive influence shaping children everyday lives proposes educating children media influences young age
stab damage common failure mode textile products especially geotextiles geotextile related products widely used road airport pipeline paper ancient chinese algorithm applied predict stab area stab energy woven fabrics stabbing load according load displacement performance single yarn research proposes novel method analyze stab property textile products
sweet syndrome inflammatory disease characterized fever leucocytosis distinctive skin lesions histologically consist dermal infiltrate neutrophils nuclear fragmentation aseptic neutrophilic inflammation may occur also organs central nervous system involvement neuro sweet syndrome nss rare reported especially among asian patients systematic review literature performed find articles reporting cases neurological involvement search terms sweet syndrome disease neurological involvement neuro sweet syndrome disease used pubmed database sixty nine nss patients including males females asian caucasian described date average age year old representative neurologic symptom altered state consciousness followed headache memory disorders differently skin district involvement nss appears common asian patients caucasian ones affects mainly male sex third fourth decade life wide range symptoms signs occur depending part nervous system affected initial presentation usually typical skin lesions followed neurological involvement however also opposite presentation simultaneous skin nervous involvement may happen awareness possible neurological complications important avoid unnecessary therapies forms meningoencephalitis lead successful treatment systemic corticosteroids
rainyday python based platform couples rainfall remote sensing data stochastic storm transposition sst modeling rainfall driven hazards floods landslides sst effectively lengthens extreme rainfall record temporal resampling spatial transposition observed storms surrounding region create many extreme rainfall scenarios intensity duration frequency idf curves often used hazard modeling require long records describe distribution rainfall depth duration provide information regarding rainfall space time structure limiting usefulness small scales contrast rainyday used many hazard applications decades data output rainfall scenarios incorporate detailed space time structure remote sensing thanks global satellite coverage rainyday used inaccessible areas developing countries lacking ground measurements though results impacted remote sensing errors rainyday useful hazard modeling nonstationary conditions elsevier ltd rights reserved
present survey existing approaches relational division rank aware databases discuss issues present approaches outline generalizations several types classic division like operations work model generalizes codd model data considering tuples relations annotated ranks indicating degrees tuples relations match queries approach utilizes complete residuated lattices basic structures degrees argue unlike classic model relational divisions fundamental operations general expressed means operations addition compare existing proposed operations identify faithful counterparts universally quantified queries formulated relational calculi introduce pseudo tuple calculus ranked model used show mutual definability various forms divisions presented paper elsevier inc rights reserved
recent research findings illustrated false memories induced laboratory dissociated beliefs events fad occurred study assessed whether dissociability quality peculiar false memory whether represents general characteristic autobiographical memory end examined whether people induced stop believing memories true experiences participants observed performed simple actions later falsely informed performed false memories actions implanted use fabricated evidence receiving misinformation participants rated belief memory performing actions actions also performed actions performed whereas misinformation substantially undermined participants beliefs specific performed actions misinformed little effect endorsement remembering actions misinformation thus boosted proportion occasions participants rated memories stronger beliefs weakened correlation belief memory ratings thus study provides first experimental demonstration non believed memories true experiences discuss findings reference small literature concerning use socially communicated misinformation undermine event memories reference structure autobiographical memory elsevier rights reserved
paper proposes method stator rotor temperature estimation based energy model permanent magnet synchronous motor pmsm used hybrid electric vehicle temperature behavior obtained motor losses cooling system model losses stator rotor calculated separately convection heat transferred rotor stator coolant modelled difference energy losses energy absorbed cooling system considered indication temperature variation inside motor
attempt minimize adverse effects television violence authors implemented classroom based intervention children classrooms grades intervention consisted brief lessons conducted university staff course months participants individually interviewed prior intervention three occasions including months concluding intervention compared participants control classrooms intervention children reported watching less violent identifying less violent superheroes also expressed critical attitudes concerning television violence results achieved girls boys across grade levels still evident months concluding intervention elsevier inc rights reserved
investigate associations bullying abuse pelvic floor symptoms urogenital pain sexual health characteristics women presenting multidisciplinary women urology center retrospective review prospective database patients completed questions bullying abuse sexual health validated questionnaires including pelvic floor dysfunction inventory pfdi overactive bladder questionnaire oab visual analog scale vas genitourinary pain statistical analyses included chi squared tests compared victims bullying abuse non victims three hundred eighty patients reviewed three hundred thirty eight data bullying abuse history reported victims bullying reported victims abuse women history bullying abuse increased overall pain scores compared without history either women history abuse bullying increased pfdi popdi udi scores compared women bullied abused difference sexually active sexual satisfaction groups patients history abuse bullying greatest percentage dyspareunia women history bullying abuse predict increased pelvic floor distress urological symptoms increased urogenital pain increased dyspareunia clinicians screen exposure bullying abuse order provide comprehensive resources address psychosocial issues
industrialized housebuilding contractors use standardized processes building systems improve time cost efficiency recent governmental investigations argue swedish local planning authorities requirement setting practices stifle potential increased industrialization yet previous research accounted industrialized housebuilders perspective aim explore industrialized housebuilders interpretations local requirement setting using institutional logics increase understanding structure human agency influence emergence local requirements interviews conducted representatives five industrialized housebuilders together span swedish multi family housing market findings indicate industrialized housebuilders perceive intentional local requirement setting problematic yet struggle cope interpretive local requirement setting findings also necessitate distinguishing local requirement setting exercise public authority local requirement setting public procurement agency structure dualism contributes understanding interpretive local requirement setting exercise public authority expression agency local requirement setting public procurement one structure furthermore using institutional logics approach found provide accentuation human agency individual level analysis often absent construction management research
apply control theoretic view movement behavior human locomotion goal using perturbations learn subtask control controlling one speed maintaining upright posture two critical subtasks underlying functions human locomotion nervous system simultaneously controls two subtasks investigated study continuous visual mechanical perturbations applied concurrently subjects probes investigate two subtasks treadmill walking novel application harmonic transfer function htf analysis human motor behavior used htfs converted time domain based representation phase dependent impulse response functions oirfs oirfs used identify mapping perturbation inputs kinematic electromyographic emg outputs throughout phases gait cycle mechanical perturbations caused initial passive change trunk orientation phases stimulus presentation corrective trunk emg orientation response visual perturbations elicited trunk emg response prior trunk orientation response subsequently followed anterior posterior displacement response finding supports notion temporal hierarchy functional subtasks locomotion control upper body posture precedes subtasks moreover novel analysis apply potential probe broad range rhythmic behaviors better understand neural control
hypergraph powerful representation several computer vision machine learning pattern recognition problems last decade many researchers keen develop different hypergraph models contrast much attention paid design hyperedge weighting schemes however many studies pairwise graphs showed choice edge weight significantly influence performances graph algorithms argue also applies hypergraphs paper empirically study influence hyperedge weights hypergraph learning via proposing three novel hyperedge weighting schemes perspectives geometry multivariate statistical analysis linear regression extensive experiments orl coil jaffe sheffield scenel caltech datasets verified hypothesis classification clustering problems classes problems empirical study concludes suggesting suitable hypergraph weighting scheme moreover experiments also demonstrate combinations weighting schemes conventional hyper graph models achieve competitive classification clustering performances comparison recent state art algorithms elsevier rights reserved
mobile technologies increasingly adopted information intensive organizations public police corporations support tasks employees information management innovation however police organizations government organizations technology decisions largely made managers politicians budget key factor therefore whether technologies adopted suitable police tasks enhance performance generally assessed aim research establish mobile technologies support police tasks tablet pcs especially suitable specialist police tasks criminal investigators sexual offence child abuse units guided interpretive paradigm theory task technology fit research explores use tablet pcs two police units improved performance information critical police tasks data collected via focus groups establishes impact technologies case investigations information management performance units use tablet pcs contribution study makes mobile information systems technology dimensions suitable information based tasks outcome virtualization processes improved performance achieved due reduced costs transparency teamwork quick informed decisions findings research used police organizations well organizations effective implementation mobile technologies
backgroundevidence suggests impulsive aggression explosive anger common among individuals anxiety disorders yet influence intermittent explosive disorder ied onset course consequences patterns comorbidity among anxiety disorders unknown methodsdata drawn national comorbidity survey replication adolescent supplement nationally representative surveys conducted diagnoses based structured lay administered interviews lifetime diagnoses assessed structured instruments outcomes included comorbidity functional role impairment treatment utilization resultsadolescents lifetime anxiety disorder higher prevalence lifetime anger attacks ied adolescents without lifetime anxiety disorder respectively especially social phobia panic disorders similar elevation found adults age onset course anxiety disorders differ ied severe functional impairment associated anxiety higher among adolescents adults ied without ied respectively comorbidity disorders elevated however individuals anxiety disorders ied likely use treatment services anxiety disorders without ied conclusionsindividuals ied concomitant anxiety disorder especially social phobia panic marked risk worse functional impairment higher burden comorbidity onset course anxiety disorder differ anxiety ied likely utilize treatment services assessment identification specialized treatment anger context anxiety disorders critical reducing burden
order improve positioning navigation performance global navigation satellite system gnss receivers novel method extract auxiliary information gnss receiver proposed paper obtains area gnss auxiliary information agai enough credibility area attribute firstly mass historical gnss intermediate frequency data divided blocks acquired tracked parallel getting massive pseudorange navigation message mpd massive mpd weighted fused parallel appropriate weight matrix determined priori weighting based altitude angle posterior weighting based residuals variable components estimation lastly fused information corresponded corresponding location coordinate completing parallel extraction agai method implemented parallel programming models mapreduce hadoop guarantee high efficiency experimental results show positioning velocity error gnss receivers reduced using agai instead traditional auxiliary information execution time method using mapreduce reduced proposed method reliable effective copyright john wiley sons ltd
internet things iot comprises complex network smart devices frequently exchange data internet given significant growth iot new technological paradigm may involve safety critical operations sensitive data put online security aspect vital paper studies network security matters smart home health care transportation domains possible interruption might occur iot devices operation causing shutdown mode taxonomy security attacks within iot networks constructed assist iot developers better awareness risk security flaws better protections shall incorporated
million git repositories github becoming one important sources software artifacts internet researchers mine information stored github event logs understand users employ site collaborate software far studies describing quality properties available github data document results empirical study aimed understanding characteristics repositories users github see users take advantage github main features activity tracked github related datasets point misalignment real mined data results indicate github rich source data software development mining github research purposes take various potential perils consideration example show majority projects personal inactive almost pull requests appear merged even though also approximately half github registered users public activity activity github users repositories always easy pinpoint use identified perils see pose validity threats review selected papers msr mining challenge see potential impacts consider provide set recommendations software engineering researchers approach data github
paper presents design digital control strategy type buck converter used efficient lead acid battery charger isolated electric photovoltaic systems strategy designed implemented digital signal processor dsp control acts depending state charge batteries regulating drive duty cycle proper combination incremental conductance mppt technique precise control battery current according three charging stages providing joint solution one hand maximizes production solar energy available array ensures long battery lifetime aspects generally investigated independently technical literature treated simultaneously approach work explains detail converter modeling project compensator well development mppt used validation simulations done via matlab experimental results prototype low power tmsf using dsp texas instruments provided discussed show satisfactory performance proposed control system elsevier ltd rights reserved
surgical sterilization primary method contraception among low income women india article using qualitative analysis key informant depth interviews quantitative analyses examines antecedents process outcomes sterilization women low income area mumbai india family planning policies socioeconomic factors gender roles constrain women reproductive choices procedures sterilization rarely follow protocol particularly pre procedure counseling consent women choose sterilization often marry early begin conceiving soon marriage reach exceed ideal family size early due problems accessing reversible contraceptives despite constraints study indicates perspective women decision undergo sterilization empowering fulfilled reproductive duties effectively exercise control fertility sexuality empowerment results little post sterilization regret improved emotional health improved sexual relationships following sterilization
objective present study designed find whether leptin predictor bone mass density bmd premenopausal women pmw postmenopausal osteoporotic women pmopw association bmd methods one hundred ninety two women pmopw pmw recruited study control group bmi matched osteoporotic subjects bmd assessment done calcaneus peripheral ultrasound bone densitometry scores determined serum leptin levels measured enzyme linked immunosorbent assay elisa results serum leptin bmd values significantly different groups leptin versus bmd versus respectively pmopw serum leptin bmd considerably correlated weight lep bmd bmi lep bmd waist circumference lep bmd hip circumference lep multivariate linear stepwise regression analysis showed weight bmi pmw pmopw independent predictors bmd serum leptin level found predictor bmd groups conclusion present results indicate body weight bmi impact bmd serum leptin associated bmd pmw pmopw
study assessed likelihood referral liver transplantation assessment prospective cohort patients infected hiv hepatitis complications cirrhosis infected patients centres least one complication cirrhosis recorded either decompensation hepatocellular carcinoma identified cirrhosis hcc referred liver transplantation assessment even though referral recommended infected patients first decompensation episode
background periaqueductal gray pag descending pain modulatory center pag dysfunction recognized migraine propose investigate altered pag texture features quantitative approach extracting texture descriptors images patients medication overuse headache moh based high resolution brain structural image understand moh pathogenesis methods brain structural images obtained normal controls moh patients system pag template created based icbm gray matter template individual pag segment performed applying deformation field pag template structural image segment grey level occurrence matrix glcm performed measure texture parameters including angular second moment asm contrast correlation inverse difference moment idm entropy results contrast increased moh patients compared area roc curve contrast distinction moh cut value contrast sensitivity specificity contrast negatively sleep scores conclusion texture contrast could used identify altered imaging characteristics moh understanding moh pathogenesis could also considered imaging biomarker moh diagnosis
absence agreement ethical legitimacy abortion entail impossibility finding consensus best policy abortion consensus affordable nobody doubts regarding methods birth control contraception better abortion abortion better infanticide abortion worse later less safe performed complete elimination abortion possible relevant realistic political objectives proposed reducing abortion rate reducing gestational age abortions making remaining abortions safer restrictive policies contribute lowering abortion rate associated unsafe abortions higher women morbidity mortality copyright john wiley sons ltd
liquid manure applied agricultural lands improves soil quality however incorrect management manure may cause environmental problems due sediments nutrients losses associated runoff aims work evaluate time effect post liquid dairy manure ldm application runoff sediment nutrient losses compare effect conventional tillage till systems runoff sediment nutrients losses ldm application rainfall simulation experiment conducted intact soil blocks collected fields conventional tillage till systems rainfall applied days ldm application conventional tillage without manure application resulted higher runoff sediment nutrient losses mainly particulate fraction till without manure greatest runoff sediment nutrients losses occurred treatments simulated rainfall performed ldm application independent tillage system interval days manure application rainfall event reduced sediment particulate particulate losses conventional till systems practical terms would recommend minimum days ldm application rainfall runoff event provide agronomic benefits minimizing potential risk water pollution elsevier rights reserved
objective research investigate relationship emotion recognition lateralization motor onset parkinson disease patients using electroencephalogram eeg signals subject pool consisted twenty patients ten predominantly left sided lpd ten predominantly right sided rpd motor symptoms healthy controls matched age gender multimodal stimuli used evoke simple emotions happiness sadness fear anger surprise disgust artifact free emotion eeg signals processed using auto regressive spectral method subjected repeated anova measures group differences observed across behavioral measures however significant reduction eeg spectral power observed alpha beta gamma frequency oscillations lpd compared rpd participants suggesting lpd patients inferred right hemisphere pathology impaired compared rpd patients emotional processing also found related emotional processing deficits may selective perception negative emotions previous findings suggested hemispheric effect emotion processing could related emotional response impairment subgroup patients study may help clinical practice uncover potential neurophysiologic abnormalities emotional changes respect patient motor onset
introduction random factors power systems probabilistic load flow plf become one important tasks power system planning operation cumulants based plf effective algorithm calculate plf analytical way however correlations among nodal injections system level rarely studied novel parallel cumulants based plf method considering nodal correlations proposed paper able deal correlations among system nodes avoid jacobian matrix inversion traditional cumulants based plf well addition parallel computing introduced improve efficiency numerical calculations accuracy proposed method validated numerical tests standard ieee system comparing results correlation latin hypercube sampling monte carlo simulation clmcs method efficiency parallel performance proven tests modified ieee systems distributed generation numerical simulations show proposed parallel cumulants based plf method considering nodal correlations able get accurate results using less computational time physical memory higher efficiency better parallel performance traditional one
series three dimensional smoothed particle hydrodynamics sph finite element models domain form water tank undertaken simulate tsunami induced bore impact discrete onshore structure dry bed fluid motion simulated using sph based software dualsphysics tsunami like waves represented solitary waves different characteristics generated numerical paddle wavemaker numerical probes uniformly distributed structure vertical surface providing detailed measures pressure distribution across structure peak impact locations structure surface specifically determined associated peak pressures compared prediction existing commonly used design equations using pressure time histories sph model analysis conducted abaqus model dynamic response representative timber structure results show equations used estimate associated pressure design purposes highly non conservative gaining detailed insight impact pressures structure response engineers potential means optimise design structures tsunami impact loads improve survivability
paper presents open course university network interactive laboratories offers several virtual remote laboratories automatic control accessible anyone details one labs two electric coupled drives system allows performing control practices mimo system industrial applications activities performed given use low cost solution developing virtual remote labs shared open course based use free authoring tool easy java javascript simulations ejss building laboratories user interfaces cheap development platform board beaglebone black virtual remote labs deployed free learning management system moodle web environment facilitates management maintenance
first part trilogy reports results combined experimental computational investigations fluid flows active space needle valves configurations characterised rounded needle tip exit channel entrance interest rounded shapes arose recently due planned needle valve applications high temperatures possibility erosion aggressive hot fluids endangering valve rapid deterioration part discusses mainly geometry problem configurations models used tests reported subsequent parts elsevier rights reserved
introduction nintedanib new anti fibrosis agent intracellular tyrosine kinase inhibitor targeting platelet derived growth factor receptor fibroblast growth factor receptor vascular endothelial growth factor receptor although nintedanib attracting much attention new treatment option patients idiopathic pulmonary fibrosis ipf clinical evidence limited mainly results dose deciding phase tomorrow trial phase iii inpulsis trials evaluated efficacy safety nintedanib patients ipf prespecified subgroup analyses pooled analyses meta analyses derived trials areas covered document mainly reviewed reports working mechanisms nintedanib efficacy safety nintedanib patients ipf literature search undertaken using pub med expert commentary unknown whether efficacy nintedanib patients enrolled clinical trials entire spectrum patients including patients unfit clinical trials due age severity timing ipf diagnosis diagnosis interstitial pneumonias ipf sufficient consideration given selecting candidates nintedanib real world
predictive nature digital soil mapping makes labour cost effective way facilitating soil surveys digital elevation model used generate terrain attributes used infer distribution soil associations relative topography two study areas gladstone potsane free state province south africa considered slope aspect contour plan curvature topographic wetness index topographic morphological unit used develop model predicting soil associations discriminant analysis employed develop model model trained data obtained gladstone validated data gladstone potsane predicting soil form unsatisfactory prediction done soil associations soils grouped deep shallow valley bottom soils criteria closely related suitability field rainwater harvesting achieved acceptable improvement prediction accuracy gladstone analysis done using equal prior probability accuracy percentages found calibration cross validation areas suited field rainwater harvesting respectively prior probability set accordance sample frequency accuracy percentages improved respectively potsane prediction accuracy percentage low equal prior probability markedly improved prior probability similar sample frequency results support validity statement predictive nature digital soil mapping makes labour cost effective way facilitating soil surveys
paper proposes supervisory power management system pms grid interactive microgrid hybrid energy storage system key feature proposed pms reduced number sensors required implement pms pms considers renewable power variation grid availability electricity pricing changes local loads detect operating mode system without measuring load currents powers single phase voltage source converter vsc transfers real power grid utility grid besides offering ancillary services harmonic mitigation reactive power support unity power factor point common coupling pcc proposed system better link voltage regulation achieved usage supercapacitors reduces current stress battery pms also addresses extreme operating conditions load shedding maximum power point tracking operation photovoltaic elimination critical oscillation hybrid energy storage systems power islanded operation resynchronization grid performance proposed pms verified digital simulation experimental studies
decline species richness altitude one obvious patterns ecology results combination ecological evolutionary mechanisms harsh high altitude environments effect altitude usually overrules environmental variables related biodiversity studies using species richness along altitude gradients high altitude relatively numerous lakes ponds however due special features small size high isolation regional variability ponds proved different systems compared lakes high altitude waterbodies species family chironomidae often dominate benthic invertebrate communities thus serve ideal model study aquatic community changes along altitude gradient however due time consuming processing expertise needed identify species chironomids often excluded regular surveys present study sampled tatra ponds altitude gradient benthic invertebrates special attention chironomids total taxa collected chironomidae constituted richest group taxa present study ponds diverse pond supported chironomid taxa mean diversity taxa pond total invertebrate richness decreased altitude chironomid richness showed weak negative response altitude proportion total chironomid diversity made tanypodinae chironominae subfamilies decreased altitude opposite trend recorded proportion diamesinae orthocladiinae
although cognitive behavioral therapy cbt widely recognized preferred treatment psychiatric disorders less known application cbt substance use disorders particularly adolescence article discusses cbt conceptualizes substance use implemented treatment adolescent substance abuse article draws several manuals cbt implement standalone treatment combination motivational enhancement therapies also reviewed several studies examined efficacy cbt finally implications discussed numerous starting resources provided help clinician implement cbt
background aimsquitting smoking potent way reduce health risks associated smoking cigarettes public health objectives united states include dramatic increases proportion smokers making serious quit attempt year centers disease control prevention cdc since set healthy people objective encourage smokers make serious quit attempt per year study assessed trend quit attempts designwe examined percentage smokers making serious quit attempt year repeating cross sectional national health interview survey nhis settingunited states participantsthe number qualifying respondents per year ranged total respondents included analysis measurementsrespondents deemed made serious quit attempt either current smokers reported stopped smoking day past months trying quit smoking reported former smokers smoked cigarettes life time smoking quit past year findingsanalyses trends showed overall linear increase quit attempts odds ratio confidence interval also quadratic trend conclusionsthe proportion smokers making serious quit attempt increased since due upward trend since serious quit attempt rate rates still healthy people objective smokers making serious quit attempt per year
medical services glasgow commonwealth games cwg provided though purpose built medical polyclinic fully equipped radiology department along services set within main games village data analysis radiology services offered cwg published imaging services within polyclinic athletes village glasgow cwg aim paper analyse data radiological investigations assess demand distribution workload imaging services cwg data radiology investigations cwg retrieved carestream picture archiving communication system pacs pharmasys cwg official centralised electronic database system analysed six hundred ninety seven diagnostic interventional procedures performed magnetic resonance imaging mri scans diagnostic ultrasound examinations radiographs computed tomography scans imaging guided interventional procedures imaging performed athletes remainder performed team officials workforce demand radiology services gradually picked pre competition period peaked half way cwg radiology played vital role successful provision medical services glasgow cwg high demand imaging services expected major international sporting events therefore pre event planning vital back facilities case technical failure given due importance planning radiology services future cwg events
paper deals leader follower formation control problem measurement constraints considered follower onboard sensor practical point view case unmanned vehicles subject limited sensing communication particular interest work based state space representation leader follower relative kinematics formation realized employing state feedback considering limited field view measurement sensor soft switching supervisory control strategy proposed paper distinct respect existing studies sensor measurements specifications leader follower system formulation proposed control strategy visibility maintenance problem simulation results verify effectiveness proposed control structure
introduction atrophic scarring occurs throughout course inflammatory acne across spectrum severity study evaluates perceptions general population toward individuals clear skin acne scars methods online survey administered usa japan germany france brazil respondents years presented three facial pictures clear skin digitally superimposed acne scars active acne lesions random fashion least one clear one scar picture presented participant results among responders facial acne scars skin first thing noticed face viewing pictures scars viewing clear skin scars less likely considered attractive confident happy healthy successful likely perceived insecure shy compared clear skin significance responses obtained varied according acne scar status respondent skin care cited habit need improvement respondents viewing pictures scars clear skin respectively respondent subgroups cited skin care irrespective acne scar status pictures clear skin scars thought less likely promising future clear skin majority respondents reported willingness pay money eradicate scars conclusion results multi national survey demonstrate facial acne scars perceived negatively society confirming importance preventing acne scars early treatment inflammatory acne
study sports injuries personality play prominent position influence particular traits occurrence thereof addition high performance sports high demanding involve exposure multiple risk factors including psychological risk factors study analyses role personality injuries elite athletes sample composed athletes members respective national teams personality assessed using injuries recorded hoc questionnaire results show significant correlations number injuries tension social boldness scales considering type injury athletes overuse injuries higher scores vigilance privateness self reliance lower scores dominance rule consciousness self control regarding mechanism injury athletes injured overloading show higher scores vigilance tension anxiety athletes injured
wastewater treatment plants wwtps key infrastructures ensuring proper protection environment mathematical modelling simulation activated sludge systems gained increasing attention control engineering within last years widely used models describe biochemical processes take place wwtp activated sludge models due increased complexity models often unsuited control systems design aim paper develop reduced order models adequately describe biochemical processes purpose line control design models developed contain minimum number variables parameters allow model identification validation based available line measurements
context electronic management without active technical means fidelity confidentiality preservation electronic document lose true evidence readability even disappear forever furthermore since computer archive management china four years earlier office automation key document archiving connection two systems essence interface solve problem data conversion data exchange heterogeneous databases view paper discusses design realization model electronic document archiving interface whose core components designed solve two problems two way conversion relational databases xml documents distributive information transmission based jms
large number computer applications like computer graphics control systems modeling system simulators etc needed floating point arithmetic however presently available methods slow inefficient sequential design however recent development field programmable logic devices fpla cpld opens new area parallel high speed floating point designs considering synchronous architectures requires clock events happen time complete circuit possible due clock skew also latency throughput circuit directly linked worst case delay slowest element increases delay hence paper presents self timed carry look ahead adder based implementation ieee bit floating point multiplier fpga devices simulation results shows proposed design lower latency synchronous design well lower power requirements
bulk heterojunction films made polychiral single walled carbon nanotubes swcnts form efficient heterojunction solar cells type crystalline silicon due superior electronic optical electrical properties films multi functional since hierarchical surface morphology provides biomimetical anti reflective air stable hydrophobic encapsulation also films large effective area conferring high optical absorption actively contribute solar energy harvesting together report photovoltaic devices photoconversion efficiency record internal quantum efficiency iqe unprecedented iqe value truly remarkable indicates every absorbed photon device wavelengths generates pair separated charge carriers collected electrodes swcnt devices favor high broadband carrier photogeneration charge dissociation ultra fast hot excitons transport electrons high mobility holes swcnt percolative network moreover varying film thickness possible tailor physical properties two dimensional interacting system therefore overall device features results pave way low cost high efficient broadband photovoltaics also promising development generic swcnt based optoelectronic applications elsevier ltd rights reserved
serotonin implicated promoting self control regulation hunger physiological homeostasis regulation caloric intake however remains unclear whether effects serotonin caloric intake reflect purely homeostatic mechanisms whether serotonin also modulates cognitive processes involved dietary decision making investigated effects acute dose serotonin reuptake inhibitor citalopram choices food items differed along taste health attributes compared placebo noradrenaline reuptake inhibitor atomoxetine twenty seven participants attended three sessions received single doses atomoxetine citalopram placebo double blind randomised cross design relative placebo citalopram increased choices healthy foods less healthy foods citalopram also increased emphasis health considerations decisions atomoxetine affect decision making relative placebo results support hypothesis serotonin may influence food choice enhancing focus long term goals findings relevant understanding decisions food consumption also treating health conditions eating disorders obesity
data driven design accurate reliable takagi sugeno fuzzy systems drawn attention several researchers recent decades according excellent ability describing non linear systems literature several fuzzy clustering algorithms proposed identify parameters involved takagi sugeno fuzzy model possibilistic means pcm one used clustering methods efficient straightforward easy implement exhibits robustness noise however pcm sensitive initialisation easily trapped local optima contrariwise pso algorithm strong global searching ability easily get local minimum overcome drawbacks pcm algorithm paper hybrid fuzzy clustering method based pcm fuzzy pso fpso proposed makes use merits algorithms experimental results applied irrigation station show hybrid algorithm pcm fpso efficient reveal encouraging results
zero potential scanning circuit widely used read circuit resistive sensor arrays removes well known problem crosstalk current zero potential scanning circuit divided two groups based type row drivers one type row driver using digital buffers easily implemented simple structure found cause large read error originates resistance digital buffers used row driver type row driver composed operational amplifiers accurately reads sensor resistance uses large number operational amplifiers drive rows sensor array therefore severely increases power consumption cost system complexity resolve inaccuracy high complexity problems founded previous circuits propose new row driver uses one operational amplifier drive rows sensor array high accuracy measurement results proposed circuit drive resistor array show maximum error remarkably reduced previous counterpart
recently shown cbl mice exhibit depression like behavior short photoperiod suggested animal model investigating seasonal affective disorder sad study tested manipulations circadian clock melatonin treatment could effectively modify depression like anxiety like behaviors brain serotonergic system cbl mice short photoperiods light dark daily melatonin treatments light offset significantly altered patterns mrna expression circadian clock genes per per bmal clock within suprachiasmatic nuclei scn mostly increasing amplitude expressional rhythms without inducing robust phase shifts melatonin treatments altered expression genes serotonergic neurotransmission dorsal raphe tph sert vmat hta serotonin contents amygdala importantly melatonin treatment reduced immobility forced swim test depression like behavior key mechanism melatonin induced antidepressant like effect previously proposed phase advance hypothesis circadian clock could confirmed conditions experiment however findings modest adjustments amplitude phase transcriptional oscillators scn result melatonin treatments may sufficient associate effects seen brain serotonergic system improvement depression like behavior study confirmed predictive validity cbl mice useful model molecular analysis links clock brain serotonergic system could greatly accelerate understanding pathogenesis sad well search new treatments
mosquito flight activity studied using variety different methodologies largely concentrates female mosquito activity vectors disease video recording using standard commercially available hardware limited accuracy measurement flight activity due lack depth perception two dimensional images multi camera observation three dimensional trajectory reconstructions remain challenging inaccessible majority researchers silica simulations used quantify limitations two dimensional flight observation observed simulated conditions two dimensional observation flight accurate determination population flight speeds thus two dimensional imaging used provide accurate estimates mosquito population flight speeds measure flight activity long periods time optimized single camera video imaging study male aedes albopictus mosquitoes time period tested two different multi object tracking algorithms efficiency flight tracking albopictus males observed active start day period longest period activity evening single mosquito fly course activity observed night period simplistic tracking methodologies executable standard computational hardware sufficient produce reliable data video imaging optimized laboratory conditions methodology require overly expensive equipment complex calibration equipment extensive knowledge computer programming technology accessible majority computer literate researchers elsevier ltd rights reserved
background vtia etfa identified recently susceptibility genes non glioblastoma gbm glioma risk european populations genetic etiology pathogenesis glioma fully elucidated aimed investigate whether common genetic variants vtia etfa predispose han chinese individuals glioma methods association thirteen common tagging single nucleotide polymorphisms snps vtia etfa genes glioma assessed hospital based case control study including non gbm glioma patients cancer free controls results two snps vtia etfa found significantly associated non gbm glioma risk adjusted adjusted odds ratio confidence interval adjusted adjusted stratified analysis pronounced adult subgroup haplotype based analysis two haplotypes identified significant association glioma haplotype tga vtia haplotype aca etfa fold fold increased glioma risk respectively compared corresponding non carriers conclusions summary results indicate genetic variants vtia etfa may modify individual susceptibility non gbm glioma han chinese population support role vtia etfa genes occurrence glioma elsevier rights reserved
show promotion intervention positive effects intergroup contact high levels compunction negative effects intergroup contact probably longest standing comprehensively researched intervention reduce discrimination also part ordinary social experience key context discrimination played paper explore two additional interventions also designed reduce discrimination yet applied real intergroup interactions promotion intervention encourages participants relax enjoy interaction compunction intervention motivates participants avoid discrimination across two studies tested separate effects promotion study compunction study participants interactions confederate believed history schizophrenia study participants received either promotion intervention relax enjoyable dialogue intervention control study participants completed single category implicit attitude test told high prejudice high compunction condition low prejudice low compunction condition results indicated promotion associated broadly positive effects participants reported positive experience interaction enjoyment interest future interaction positive evaluations contact partner increased friendliness reduced stereotyping effects participants reported intergroup anxiety contrast high compunction broadly negative effects participants reported negative experiences interaction negative evaluations contact partner using dependent measures outlined addition participants high compunction condition reported increased intergroup anxiety increased self anxiety anxiety around thinking something prejudiced participants high compunction condition also reported reduced expectancies self efficacy less confident would able make good impression
following paper highlights enhancement promotion campania region rural tourism plus green building importance kind sustainable competitive one providing ideas valuable suggestions natural environmental cultural assets landscape properly exploited rural tourism values traditions reaffirmation also applies interest rural buildings landscape architecture rural tourism concerns health protection welfare expressed pleasure life air water quality genuine healthily food eco friendly facility rural landscape used source satisfaction relax green building means build aim ensuring people wellbeing regarded physical mental condition individual health socio economic balance environmental protection play role ideal prototype rural tourism encourage practices making farm agro tourist accommodation service architecturally sustainable environmental landscape context promoting creative activities keeping natural historical setting authors published elsevier open access article license
green buildings needs use green renewable energy solar energy one largest green energy storage therefore application solar energy plays important role green building solar energy resources application current situation solar energy paper highlights solar technology used green building stage necessary analysis different forms applications
study dynamic scheduling problem jobs fixed start end times multiple machines problem design efficient data structures support update operations insertions deletions jobs call period time schedule two consecutive jobs given machine idle interval show set jobs exists schedule corresponding set idle intervals forms tree set theoretic inclusion prove schedule optimal based result provide data structure maintains updates optimal schedule worst case time depth set idle intervals number jobs furthermore show bound tight
background acute diarrhea second common cause morbidity mortality worldwide especially children aged years drugs mucoprotector gelatin tannate plus reduced osmolality oral rehydration solution ors may effectively reduce symptom duration severity current trial therefore designed assess efficacy safety gelatin tannate pediatric patients acute diarrhea material methods randomized controlled double blind parallel group single center study comparing gelatin tannate plus ors patients ors plus placebo patients children aged months years infectious noninfectious acute diarrhea details stool consistency total time resolution diarrhea comprised primary study endpoints secondary study endpoints included symptoms diarrhea hours first dose study medication results hours onwards incidence watery stools significantly lower gelatin tannate group ors group hours true stool frequency hours mean stool productions previous hours timepoints study proportion patients stool decrease index improvement significantly greater gelatin tannate group placebo group hours conclusions gelatin tannate plus ors effective safe option treatment acute diarrhea children significant symptom relief evident hours starting treatment
paper present complete overview ambient intelligence ami focused applications considering involved domain technologies applications include ami home care elderly people disabilities healthcare education business public services leisure entertainment aim survey ami applications show socials ethical implications specially privacy issues intelligent environments collect process massive amount person related sensitive data data must ensure privacy users important concern ami applications privacy addressing design privacy important challenge consider development architecture includes different privacy policies fusion specific application domain ensuring privacy intelligent environments difficult problem solve different perceptions privacy role computing user called design privacy identify relevant design issues addressed developing present approach dimensions consider order provide privacy design ambient intelligence applications
dual input led lighting scheme constant illumination proposed paper scheme employs photovoltaic array first input battery second one microcontroller programmed operate changeover switch well converter uninterrupted constant illumination work place scheme suitable conference halls laboratories clean rooms marriage halls theaters etc complete modeling design experimentation proposed scheme explained economic viability scheme justified
gender critical social factor influencing children view world early childhood additionally early elementary years parents significant influence child behaviors dispositions fields science study examined influence parent gender child gender grade children strategies solving science problems parents well attitudes science behaviors parent child dyads solved hands science problems together informal setting examined child interview parent questionnaire used elicit information attitudes toward life science compared physical science quantitative qualitative analyses parent child interactions revealed differences amount encouragement offered boys versus girls additionally differences questioning behaviors parents function parent gender child gender furthermore parental interest various science topics differed along traditional gender roles whereas boys girls interested topics disciplines
rail networks new locomotives using four quadrant rectifiers responsible low frequency disturbances overhead line voltage recent years around world interactions locomotives power supply observed sectors french rail network serious disturbances affected rail system operation flicker observed upstream electrical network prevent dysfunctions analysis method proposed locomotive multiple unit train characterized admittance matrix using voltage source converter stability study performed critical area view determine acceptable number locomotives equipped active front end rectifiers
background insufficient predictive markers renal cell carcinoma rcc methods total metastatic rcc patients analyzed retrospectively results increased hemoglobin group significantly higher progression free survival overall survival compared decreased group versus months versus months respectively year rates higher increased group versus versus respectively conclusions present study showed increased levels tyrosine kinase inhibitor therapy could predictive marker rcc
sorption long lived fission products smectite rich natural clay originated western part india studied batch sorption method varying experimental conditions ionic strength metal ion concentration temperature low metal ion concentration experiment achieved using carrier free radiotracer prepared using nuclear reaction ion exchange based modelling sorption data carried delineate sorption mechanism fission products clay evaluation engineered barrier buffer material indian deep underground geo repository disposal vitrified high level liquid waste modelling sorption data two sorption sites found one sites selective high log value affinity pattern site conformity effect electrostatic charge metal ion ion exchange process ion exchange sorption observed single surface site affinity binding site log found higher observed log thermodynamically characterize sorption sites sorption clay carried degrees significantly different ratio thermodynamic parameters enthalpy entropy values obtained two sorption sites negligible temperature effect exchange clay
micrornas play important role development progression various diseases idiopathic pulmonary fibrosis ipf although accumulation aberrant fibroblasts resistant apoptosis hallmark ipf lungs mechanism regulating apoptosis susceptibility fully understood investigated role mir downregulated microrna ipf lungs also known regulator extracellular matrix ecm mechanism apoptosis resistance found functional inhibition mirc caused resistance fas mediated apoptosis lung fibroblasts furthermore experiments using mir inhibitor mir mimic revealed mir regulated expression death receptor fas formation death inducing signaling complex leading extrinsic apoptosis representative profibrotic transforming growth factor tgf beta downregulated expression mir well fas receptor conferred resistance apoptosis also found introduction mir mimic abrogated tgf beta induced phenotypes fas repression apoptosis resistance results presented suggest downregulation mir observed ipf lungs may associated apoptosis resistant phenotype ipf lung fibroblasts via downregulation fas receptor therefore restoration mir expression ipf lungs could inhibit accumulation ecm also normalize sensitivity apoptosis lung fibroblasts may effective strategy treatment ipf
paper aims propose methodology optimization solar chimney power plants taking account techno economic parameters indicator used optimization comparison actual achieved simple payback period design minimum possible optimum simple payback period reference optimization model executed different twelve designs range cover reinforced concrete chimney sloped collector floating chimney height chimney optimized associated collector area calculated accordingly relationships payback periods electricity price peak power capacity power plant developed resulted payback periods floating chimney power plants shortest compared studied designs solar chimney power plant electricity price usd kwh simple payback period reference case years floating chimney design compared years reinforced concrete chimney sloped collector design respectively design optimization power plant reinforced concrete sloped collector floating chimney save million usd respectively initial cost reference case achieved sensitivity analysis conducted study evaluate impacts varied running cost solar radiation electricity price payback periods solar chimney power plant floating chimney design still performing applying highest ratio annual running cost annual revenue sensitivity analysis showed solar radiation electricity price simple payback period sloped collector design would almost double simple payback period floating chimney design elsevier ltd rights reserved
prevalence child abuse higher families psychosocial vulnerabilities one parents experienced abuse neglect childhood widespread intervention approaches canada material support parenting skills programs show mixed results providing changes mistreatment cycles examine clinical practice focused generational repetition trauma order explore topic paper objectives supported narrative review literature document causalities child maltreatment identify clinical challenges struggling parents develop critical analysis intervention programs commonly spread canada take account multifaceted vulnerabilities families innovative practice perspectives societe francaise psychologie published elsevier masson sas rights reserved
nettun new technologies tunnelling underground works project run consortium industrial research development laboratories small medium enterprises organizations across countries europe ultimate goal enable groundbreaking change construction management maintenance tunnels nettun aims developing fully automated system installed tunnel boring machine tbm provides identification large obstacles obstruct digging tunnels cavities boulders foundations archaeological remains etc well soil changes gravel fractured rock
impulsivity often related aggressive self mutilative behavior borderline personality disorder bpd many authors focused key role emotion dysregulation explaining vulnerability dysfunctional behavior bpd addition trait impulsivity furthermore recent works shed light gap empirical research concerning specific mechanisms lack affective regulation produces aggression proneness purpose study investigate role impulsivity emotion dysregulation determining vulnerability aggression deliberate self harm sample bpd outpatients enrolled patients bpd completed comprehensive assessment personality disorder symptoms trait impulsivity emotional dysregulation aggressive self mutilative behavior trait impulsivity significantly predicted aggressive self mutilative proneness furthermore emotion dysregulation found significantly account vulnerability aggression self injury addition variance explained impulsivity conclusion findings support evidence emotion dysregulation plays important role increasing risk dysfunctional behavior impulsive bpd individuals
satellite remote sensing platforms collect measurements global scale within days provides unprecedented opportunity characterize understand spatio temporal variability environmental variables additional challenges making precise accurate measurements space essential validate satellite remote sensing datasets highly precise accurate ground based measurements focus article two sets measurements atmospheric column averaged carbon dioxide collected orbiting carbon observatory oco mission target mode operation ground based data used validation total carbon column observing network tccon current statistical modeling relationship less precise oco satellite data precise tccon ground based data assumes linear regression heteroscedattic measurement errors reside oco data tccon data obtain consistent estimates regression coefficients critical determine error variance datum regression article rigorous statistical procedure presented obtaining error variances modeling spatial temporal dependence structure oco tccon datasets numerical results analyzing data lamont tccon station corresponding oco target mode data orbit number illustrate procedure
study objectives addition enhancing sleep onset maintenance desirable insomnia therapeutic agent would preserve healthy sleep ability wake respond salient situations maintaining sleep irrelevant noise dual orexin receptor antagonists doras promote sleep selectively inhibiting wake promoting neuropeptide signaling unlike global inhibition central nervous system excitation gamma aminobutyric acid gaba receptor gabaar modulators evaluated effect dora versus gabaar modulators underlying sleep architecture ability waken emotionally relevant stimuli versus neutral auditory cues performance sleepiness sensitive cognitive task upon awakening methods dora gabaar modulators eszopiclone diazepam evaluated adult male rhesus monkeys continuous polysomnography recordings crossover studies sleep architecture arousability classically conditioned salient versus neutral acoustical stimulus psychomotor vigilance task pvt performance awakened results compounds decreased wakefulness dora sleep resembled unmedicated sleep terms underlying sleep architecture preserved ability awaken salient conditioned acoustic stimuli maintaining sleep neutral acoustic stimuli congnitive impairment pvt performance although gabaar modulators induced lighter sleep monkeys rarely woke salient stimuli pvt performance impaired monkeys awakened conclusions nonhuman primates doras targeted mechanism promoting sleep protects ability selectively arouse salient stimuli perform attentional tasks unimpaired suggesting meaningful differentiation hypnotic agent works antagonizing orexin wake signaling versus sedative hypnotic effects gabaar modulator mechanism action
generalized predictive closed loop control strategy improve basal ganglia activity patterns parkinson disease explored paper based system identification input output model established reveal relationship external stimulation neuronal responses model contributes implementation generalized predictive control gpc algorithm generates optimal stimulation waveform modulate activities neuronal nuclei analyzing roles two critical control parameters within gpc law optimal closed loop control capability restoring normal relay reliability thalamus least stimulation energy expenditure achieved comparison open loop deep brain stimulation traditional static control schemes generalized predictive closed loop control strategy optimize stimulation waveform without requiring particular knowledge physiological properties system type closed loop control strategy generates adaptive stimulation waveform low energy expenditure potential improve treatments
study aimed test knowledge emergency contraception according age sexual initiation type school knowing someone already used emergency contraception influences method use cross sectional study probabilistic sample students years age enrolled public private middle schools medium sized city southeast brazil data collected using self administered questionnaire structural equations model used data analysis considering age sexual initiation type school knowledge emergency contraception associated use knowing someone used method showed significant mean effect use emergency contraception peer group conversations emergency contraception appear greater influence use method knowledge economic status sexual experience
tokamak plasma prone many random events potential causing severe damages machine disruptions production elimination high energy runaway electrons etc events mitigated obtaining pre cursor signal leading events taking proper measures onset avoid happenings like disruptions mitigated massive gas injection putting bias voltage electrode placed inside plasma runaways mitigated gas injection applying specific magnetic fields hence real time control events pre cursors electronically recorded mitigation techniques initiated sending triggers individual operational systems implement methodologies real time controlling events aditya tokamak low cost multi channel micro controller based timing circuit designed developed house circuit first compares precursor signals fed pre set values gives trigger output whenever signals overshoot pre set values circuit readies operation along start tokamak discharge waits initial pre determined delay initiates trigger time overshooting precursor signal circuit fully integrated assembled compact enclosure local lcd threshold initial trigger delay monitoring indicators full stand alone operation system successfully tested disruption control experiment two different techniques viz electrode biasing icrh pulse techniques aditya tokamak increase mhd oscillation amplitude gas puff induced intensity increase used precursor triggering electrode bias icr pulse respectively real time disruption control application runaway mitigation disruption phase local vertical field perturbation lvf real time feedback mode performed using circuit runaway flux amplitude beyond pre set threshold used precursor triggering lvf current pulse detailed design features results described paper addition circuit also used single loop online plasma electron density control well position control elsevier rights reserved
explore amorphous soft magnetic alloys candidates electric motor applications rich system combines benefits low hysteretic eddy current losses exhibiting negligible magnetostriction robust mechanical properties amorphous precursors devitrified form nanocomposite magnets superior characteristics materials offer advantages ease handling manufacturing processing low iron losses motor operation rich amorphous ribbons laser cut build stator small demonstrator permanent magnet machine motor tested rpm finite element analyses proved iron losses rich amorphous stator smaller steel stator motor rpm equivalent electric frequency khz low loss soft magnets great potential application highly efficient high speed electric machines leading size reduction well reduction replacement rare earths permanent magnet motors studies evaluating processing techniques amorphous nanocomposite materials needed
open platform communication opc unified architecture iec introduced key technology realizing variety smart grid use cases enabling relevant automation control tasks opc expand interoperability power systems top level management platform needs independent middleware transparently manage power information technology systems including iec expand interoperability power system large number stakeholders various standards paper focuses iec digital substation paper propose interconnection method integrate communication opc convert opc addressspace using system configuration description language scl iec implemented mapping process verification interconnection method interconnection method paper expand interoperability power systems opc integration various data structures smart grid
summary families psychosocial risk live personal contextual circumstances hinder parenting skills frequently lack resources necessary addressing challenges parenting encounter multiple stressful life events social support may help diminish parenting stress experienced living disadvantaged environment enhancing coping strategies however previous research examining associations parenting stress social support among risk families inconclusive study analyzed psychosocial profile risk portuguese families size composition social support networks associations social support parenting stress participants consisted parents mothers received assistance child protection services measures included parenting stress index short form arizona social support interview schedule socio demographic questionnaire findings parenting stress levels extremely high parents showing clinically significant levels emotional support type support closely related parental distress namely network size available providing emotional support satisfaction emotional support received applications size emotional support network significantly smaller among parents reported clinically significant levels parenting stress hence opportunity express feelings concerns well engaging social interactions leisure time may serve protective factors parental stress risk families implications interventions professionals work risk families discussed
internet things iot emerging network paradigm aims obtain interactions among pervasive things heterogeneous networks security important task iot luo secur commun netw proposed certificateless online offline signcryption coosc scheme iot hereafter called ltx unfortunately shi showed ltx secure adversary easily obtain private key user ciphertext recently proposed new coosc scheme hereafter called lzz however ltx lzz need point multiplication operation online phase suitable resource constrained devices overcome weakness propose new coosc scheme prove security random oracle model addition analyze performance scheme show application iot
background healthy sleep facilitates consolidation newly acquired memories although patients posttraumatic stress disorder ptsd often complain sleep disturbances memory deficits interrelatedness symptoms well understood sleep may disturbed ptsd increased awakenings sleep associated decreased growth hormone secretion conducted controlled study assessed sleep fragmentation nocturnal secretion memory consolidation patients ptsd methods sleep eeg monitored veterans ptsd trauma controls healthy controls slept catheter blood collected every min declarative memory encoding assessed word task sleep consolidation assessed next morning free recall results sleep fragmented patients ptsd awakenings first half night plasma levels night significantly decreased ptsd compared furthermore secretion awakenings independent predictors delayed recall lower ptsd compared conclusions data show ptsd associated increased awakenings sleep decreased nocturnal secretion furthermore decreased secretion may related sleep fragmentation variables may exert negative effect sleep dependent memory consolidation elsevier ltd rights reserved
equality problem usually one first encounter communication complexity one fundamental problems field although deterministic randomized communication complexity settled decades ago find several new things say problem focusing three subtle aspects first consider expected communication cost worst case input protocol uses limited interaction bounded number rounds communication whose error probability zero close second treat false negative error rate separately false positive error rate third consider information cost protocols obtain asymptotically optimal rounds versus cost tradeoffs equality expected communication complexity information complexity scale number rounds logs bounds hold even false negative rate approaches case zero error communication cost obtain essentially matching bounds tiny additive constant also provide applications application information cost bounds obtain new bounded round randomized lower bounds intersection problem two players hold subsets many realistic scenarios sizes significantly smaller impose constraint study minimum number bits parties need communicate order compute entire intersection set using rounds show round protocol information cost thus communication cost bits also give round protocol achieving bits gives protocol bits communication contrast basic problems computing union symmetric difference bits communication required number rounds
paper presents comparative study traditional pid controller fractional order pid fopid controller regulate steam temperature single input single output small medium industry steam distillation siso smisd plant predetermined set point fractional order controller designed based principle classical integer term term pid controller generalize non integer order operation fopid consists addition lambda parameters algorithm compare traditional pid structure several fractional order applications implemented control engineering applications liquid level control autonomous underwater vehicle auv nuclear reactor power many controller performance transient responses evaluated based rise time settling time mse index
backgroundapproximately youth anxiety disorders achieve remission substantial reduction symptoms following treatment highlighting need identify predictors treatment response given well established link attentional biases anxiety disorders youth adults study examined neural correlates directing attention toward away emotional faces relation pediatric anxiety treatment response methodprior beginning treatment selective serotonin reuptake inhibitor ssri sertraline cognitive behavior therapy cbt youth age years generalized social anxiety disorder completed task conditions manipulated whether participants instructed match emotional faces explicit emotion processing match shapes context emotional face distractors implicit emotion processing functional magnetic resonance imaging resultsresults revealed reduced activation superior frontal gyrus sfg encompassing dorsal anterior cingulate cortex acc dorsomedial prefrontal cortex pfc implicit processing emotional faces predicted greater reduction anxiety severity pre post treatment post hoc analyses indicated effects significantly moderated type treatment anxiety type conclusionsfindings suggest less recruitment sfg including dorsal acc dorsomedial pfc implicit emotion processing predicts greater reduction youth anxiety symptoms pre post treatment youth exhibit reduced activation areas matching shapes context emotional face distractors may gain cbt ssri treatment due preexisting deficits attentional control findings suggest neuroimaging may useful tool predicting youth likely benefit anxiety treatment
railway similar branches global economy commonly uses information technologies business includes inter alia issues railway traffic management rolling stock management stacking timetables information passengers booking selling tickets variety aspects international railway operations well large number companies operating global railway market causes currently use lot independent systems often work together lack international standards data structures protocols causes need design maintain multiple interfaces approach inefficient time consuming expensive therefore initiative develop open international standard exchange data railway application established standard named railml paper also focus new topological model suitable used members uic international union railways railtopomodel international railway standard irs define data model corresponding data exchange format unified standardised data structures application independent producer independent simplify data exchange railway systems reduce number interfaces required systems cooperation useful cost effective technological solution current state railml railtopomodel specification trend development discussed
multiphase drives convenient high power high current applications allow reduction phase current given rated power phase voltage addition possess inherent fault tolerant capability due redundant structure therefore multiphase drives represent promising solution safety critical applications electrical ship propulsion railway traction hybrid electrical vehicles hev wind power generation electric engine mee electric aircraft mea applications moreover additional degrees freedom exploited integrated battery chargers although literature reports many machine design solutions control techniques multiphase drives penetration multiphase solutions transportation electrification energy production still limited reason paper contains brief overview multiphase solutions transportation electrification energy production addition paper includes generic modeling approach multi three phase machines used multiphase drive treated modular independent three phase units experimental results provided reduced scale prototype twelve phase multiphase induction motor drive using control scheme based multi three phase approach
congenital malformations abnormalities structures arising prenatal development hampering body functions later life causes genetic environmental kind drug exposure pregnancy one important causes infant mortality developing countries pakistan perinatal deaths attributed comprehensive nation wide data prevalence nature dynamics largely missing hence aim present study forecast prevalence multiethnic multilinguistic population rawalpindi islamabad inference engine inference engine helps formulating new conclusions data provided inference engine stored knowledge base inference engine pilot engine presents comprehensive overview neonatal maternal parameters highlights potential risk factors associated formulating new conclusions additionally inference engine would helpful establish dynamics society anticipated project conducted country wide sample could highly beneficial guiding national health policy resource allocation management
paper discuss mobile robot campro ris provides visual support human activities projecting information onto surfaces various objects living spaces structured environment approach campro ris employs parallel two wheeled vehicle system camera projector whose angle controlled pan tilt actuator actively examining visual markers placed environment advance robot projects distortion free image onto surfaces located arbitrary distances orientations precisely project image onto target location simultaneously avoiding obstacles around robot staying within pan tilt actuator movable range newly propose robust projection control method built upon image based visual servoing technique based actuator redundancy effectiveness proposed method demonstrated three dimensional experimental system
background objective study present month lifetime prevalence correlates comorbidity treatment disability dsm bipolar disorder methods nationally representative adult sample national epidemiologic survey alcohol related conditions iii results prevalences month lifetime dsm bipolar disorder differ men women prevalences bipolar disorder greater among native americans lower among blacks hispanics asians pacific islanders whites rates also lower among younger older individuals previously married currently married lower education income relative higher education income bipolar disorder strongly related borderline schizotypal personality disorders adjusted odds ratios aors anxiety disorders aors substance use disorders aors overall among men women quality life lower among individuals bipolar disorder relative without disorder treatment rates among individuals bipolar disorder low total sample among men among women conclusions bipolar disorder continues common disabling highly comorbid disorder among men women contributing substantially low quality life burden disease society published elsevier ltd
durability building materials key parameter sustainable construction premature deterioration concrete structures occurs sewage water pipelines concrete waste water systems due microbial activity sulphate reducing bacteria srb sulphur oxidizing bacteria sob prolong life time concrete structures concrete durability aggressive sulphate environment improved partial replacement cement several waste materials incorporation slag silica fume zeolite concrete composites positively influence important concrete characteristics water absorption capacity thus waste based concretes contribute increased durability structures also minimization wastes using building industry addition saving raw materials cement production considered resource efficient materials thus green building materials well paper presents results testing water absorption capacities concrete composites different compositions day exposure sulphate bacterial environment mixtures cement replaced granulated blast furnace slag proportions mixture hybrid cement used concrete specimens without cement replacement placed sulphate environment bacteria acidithiobacillus thiooxidans days experiments proceeded model laboratory conditions water absorption capacities measured according common test procedures experiments
paper studies design microwave external applicator based impedance matching paper deal topology signal flow graph applicator coupled biological tissue
aims large scale epidemiological studies show significant prevalence gambling disorder adolescence emerging adulthood highlight need identify gambling related behaviors early ages however handful screening instruments population many studies measuring youth gambling problems use adult instruments may developmentally appropriate aim study validate spanish version canadian adolescent gambling inventory cagi among late adolescent young adults explore psychometric properties methods sample years old included clinical group patients control group results exploratory factor analysis yielded one factor best model item scale demonstrated satisfactory reliability internal consistency cronbach alpha alpha satisfactory convergent validity measured correlation south oaks gambling screen excellent classification accuracy auc sensitivity specificity conclusion results provide empirical support validation spanish version cagi uphold spanish cagi used brief reliable valid instrument assess gambling problems spanish youth
develop algorithm meshing molecular surfaces based patch wise meshing using advancing front method adapted particular case molecular surfaces focus solvent accessible surface sas solvent excluded surface ses essential ingredient newly developed analysis surfaces allows describe ses singularities priori therefore complete characterization ses addition algorithm filling molecular inner holes proposed based pre computed data structures molecular surfaces elsevier inc rights reserved
ambient intelligence new paradigm information technology empower people paradigm highlights human interaction machines makes smart technologies good candidate development various real life solutions field health care including human activity recognition smart homes since description user activity plays important role smart environment recognition tracking user activities daily living provide unprecedented opportunities health monitoring applications assistive life utilities particularly elderly disabled people dementia alzheimer disease due sensor data nature different sampling rates complex correlations significant challenges arise due storage presentation exchange manipulate data category one rational solution solve challenges use techniques based semantic web ontology recently large varieties proposed approaches use techniques vast amount human activity recognition smart home using ontological approaches made difficult make adequate comparisons accurate assessment article presents framework analyzing approaches proposed regard using proposed sonar framework ontology based activity recognition approaches effective analyzing evaluating different methods different application areas dealing various challenges
electric motor influences surroundings stray magnetic fields influence matter certain cases hence reduction field intensity outside motor part motor design primary objective provide safety region humans reduce low frequency electromagnetic emission produce magnetically silent electrical machines propulsion military oceanographic ships low magnetic stray fields required paper analyses particular case influence stray magnetic fields motor multi motor assembly several stepper motors rotor position motor affected stray magnetic fields nearby motors finite element analysis mutual influence provided construction change suggested reduce position shift rotor due rotation neighbouring rotors
background despite clinical practice guidelines recommending routine provision nicotine dependence treatment smokers inpatient psychiatric facilities prevalence treatment provision low aim study examine effectiveness clinical practice change intervention increasing clinician recorded provision nicotine dependence treatment patients inpatient psychiatric facilities methods undertook interrupted time series analysis nicotine dependence treatment provision clinical practice change intervention increase clinician recorded provision nicotine dependence treatment hospital discharges aged years month period two inpatient adult psychiatric facilities new south wales australia clinical practice change intervention comprised six key strategies leadership consensus enabling systems procedures training education information resources audit feedback site practice change support officer systematic medical record audit segmented logistic regression used determine differences proportions nicotine dependence treatment outcome measure pre post intervention periods results prevalence five outcome measures increased significantly pre post intervention periods including clinician recorded assessment patient smoking status adjusted odds ratio aor confidence interval assessment patient nicotine dependence status aor provision brief advice quit aor provision nicotine replacement therapy aor provision nicotine dependence treatment discharge aor conclusions first study provide evidence clinical practice change intervention may increase clinician recorded provision nicotine dependence treatment inpatient psychiatric settings intervention offers mechanism psychiatric facilities increase provision nicotine dependence treatment accordance clinical guidelines
background poor clinical record keeping hinders health systems monitoring patient care many low resource settings develop validate novel method impute dates antiretroviral treatment art initiation routine laboratory data south africa public sector hiv program method enable monitoring national art program using real time laboratory data avoiding error potential chart review methods developed algorithm impute art start dates based date patient art workup laboratory tests used determine treatment readiness national guidelines time art workup initiation based clinical protocols days validate algorithm analyzed data two large clinical hiv cohorts hlabisa hiv treatment care programme rural kwazulu natal right care cohort urban gauteng cohorts contain known art initiation dates laboratory results imported directly national health laboratory service assessed median time art workup art initiation calculated sensitivity specificity positive predictive value ppv negative predictive value npv imputed start date true start date within month window heterogeneity assessed across individual clinics time results analyzed data hiv positive adults among patients workup initiated art median time initiation days iqr hlabisa iqr rtc cohort among patients known art start dates imputed start date hlabisa rtc indicating method accurately predicts art start dates art initiators hlabisa ppv indicating patients lab workup true start dates predicted high accuracy npv also high conclusions routine laboratory data used infer art initiation dates south africa public sector care provided based protocols laboratory data used monitor health systems performance improve accuracy completeness clinical records
tumor necrosis factor like weak inducer apoptosis tweak proinflammatory cytokine involved pathogenesis abnormal disregulated inflammation verify tweak fibroblast growth factor inducible gene signals affect development cells arthritis utilized skg mouse spontaneously develops mediated autoimmune arthritis administered zymosan induced arthritogenic skg mice effects vivo examined destruction cartilage bone damage assessed hematoxylin eosin safranin staining affected tissues phenotypic analysis cells expressing inflammatory cytokines angiogenesis related factors expression transcription factor stat affected joints determined immunohistochemistry blockade reduced clinical histologic scores inflammatory arthritis mouse model spontaneously developed chronic autoimmune arthritis suppressed production inflammatory cytokines angiogenesis promoting factors vascular endothelial growth factor matrix metalloproteinase moreover blocking tweak signal inhibited expression stat well interleukin produced cells results implicate tweak potential molecular target treatment prevention inflammatory arthritis autoimmune diseases rheumatoid arthritis
objectivethe purpose study evaluate psychometric properties newly developed headache triggers sensitivity avoidance questionnaire htsaq designed measure variables relating trigger avoidance model headaches backgroundthe trigger avoidance model headaches proposes one pathway developing primary headache disorder avoidance headache triggers resulting increase trigger potency sensitization conversely prolonged exposure certain triggers may reduce potential trigger ability precipitate headache model led alternative approach trigger management proposed called learning cope triggers advocates desensitization certain headache triggers controlled exposure supporting avoidance triggers detrimental health wellbeing able evaluate predictions based trigger avoidance model headaches investigate effectiveness learning cope triggers psychometrically sound measures trigger sensitivity trigger avoidance needed methoda convenience sample participants female european descent recruited online study consisted battery measures including htsaq brief headache screen pain anxiety symptoms scale pain sensitivity questionnaire chronic pain acceptance questionnaire demographic items interval weeks subsample participants completed htsaq second time mean age sample years common headache diagnoses based brief headache screen migraine chronic episodic followed medication overuse headache remaining participants diagnosed episodic less severe headache likely tension type headache resultsreliability assessed internal consistency test retest reliability period weeks excellent alpha strong construct validity demonstrated measure scale scores significantly correlated theoretically consistent ways pain sensitivity questionnaire pain anxiety symptoms scale chronic pain acceptance questionnaire trigger avoidance model headaches would predict correlations htsaq sensitivity scales avoidance scale strong participants chronic migraine significantly higher htsaq scores episodic headaches conclusionthe findings support use htsaq valid reliable tool assessing sensitivity headache triggers avoidance headache triggers research examining factor structure htsaq warranted
stress coping couples received increased research attention past two decades particularly regard couples cope stress dyadic coping emerged strong predictor relationship satisfaction less research focused effects dyadic coping outcomes family members present study authors addressed gap examining parents dyadic coping predictor children internalizing symptoms externalizing symptoms prosocial behavior three independent studies studies self report data used assess parents dyadic coping parents children perspective study included observational data dyadic coping parental dyadic coping related children externalizing symptoms internalizing symptoms prosocial behavior although results latter two outcomes consistent across three studies findings suggest parents dyadic coping deserves greater consideration within context child development
development technologies nowadays moving speed computer graphics simulations convincingly displaced augmented reality sandbox created oliver kreylos one many examples reality supplemented computer generated input case reality box full sand input hypsometric coloring elevation contours kinect sensor detects micro relief forms sandbox unnoticeable computer estimation relief map projected sand forms changing coloring lines changing project new accurate relief actually sandbox represents important conceptions geology hydrology ecology topographic mapping etc entertaining spectacular way children students main reason system part equipment laboratory cartography uaceg included lessons games sandbox irreplaceable tool improving knowledge disastrous events floods drought fire especially gives opportunity making virtual rain isolating flooded areas depending relief watersheds paper detailed presentation sandbox working system proposals educational activities large age range children university students made order use augmented reality special instrument displaying disastrous events new ideas suggested consideration future improvement sandbox meet needs educational training disaster response children
important number academic tasks solved collaboratively groups learners computer supported collaborative learning cscl systems support collaboration means shared workspaces tools enable communication coordination learners successful collaboration interaction depend criteria followed forming groups learners paper proposes method analyses collaboration interaction learners using set indicators variables solve academic tasks concept data depth used measurement closeness analysis indicators values learner respect values indicators take learners finally data depth used form new groups learners whose analysis indicators take similar different values thus method enables teachers form homogeneous heterogeneous groups according preferences group formation process carried automatically software tool paper presents two case studies method applied form groups learners solve academic tasks different domains computer programming data mining elsevier ltd rights reserved
background activation pattern localized reentry atrial tachycardia remains incompletely understood used ultra high density rhythmia mapping system study activation patterns methods results suggested small rotatory activations carousels containing full spectrum colorcoded map twenty three left sided atrial tachycardias mapped patients age years points displayed per map collected minutes total carousels identified median quartiles per map although represented rotation occurred around small area scar diameter electrograms along carousel encompassed full tachycardia cycle length surrounding activation moved away carousel directions ablating fractionated electrograms tachycardia cycle length within carousel interrupted tachycardia every case remaining carousels pseudo reentrant occurring areas wavefront collision median quartiles per map artifact annotation noise interpolation areas incomplete mapping median quartiles per map pseudo reentrant carousels incorrectly ablated cases misinterpreted conclusions activation pattern small stable rotational activations carousels drove postablation atrial tachycardias however appearance often pseudo reentrant must differentiated interpretation electrograms candidate circuit activation wider surrounding region
antimicrobial resistance gram positive bacteria remains challenge infectious diseases mission gram positive committee antibacterial resistance leadership group arlg advance knowledge prevention management treatment challenging infections improve patient outcomes committee prioritized projects involving methicillin resistant staphylococcus aureus mrsa vancomycin resistant enterococci vre due scope medical threat posed pathogens approved arlg projects involving gram positive pathogens include pharmacokinetics pharmacodynamics study evaluate impact vancomycin dosing patient outcome mrsa bloodstream infection bsi defining testing validating innovative assessments patient outcomes clinical trials mrsa bsi testing new strategies stepdown antibiotic therapy mrsa bsi management staphylococcal bsis neonatal intensive care units defining impact vre bacteremia daptomycin susceptibility patient outcomes article outlines accomplishments priorities challenges research infections caused gram positive organisms
background improving quality care patients vascular disease priority clinical guidance emphasised importance early identification active management chronic kidney disease ckd primary care order maintain vascular health however awareness stage ckd amongst patients remains limited aimed identify predictors patient self report ckd inform tailoring conversations around ckd primary care diverse patient populations methods conducted cross sectional analysis baseline data patients stage ckd practices taking part randomised controlled trial rct evaluating complex self management intervention aimed support maintenance vascular health patients stage ckd potential predictors patient self report ckd included demographics stage ckd cardiovascular risk self reported morbidities health status self management ability health service utilisation results around half patients self report ckd self report rates appreciably differ practice multivariate analysis revealed female patients patients stage ckd higher anxiety levels likely self report ckd conclusions self report kidney problems patients ckd registers variable patterned sociodemographic factors although assumed failure self report indicates lack awareness ckd data suggest need greater consistency discussions around kidney health meaningful relevant clinical dialogue aligned existing clinical encounters enable shared decision making minimise anxiety
background irritable bowel syndrome ibs affects adults associated significant impairment health related quality life hrqol however information specific diarrhea subtype ibs lacking assessed impact ibs hrqol work productivity daily activities associated indirect costs among sample population methods respondents years national health wellness survey reported ibs diagnosis physician symptoms consistent rome criteria ibs identified ibs controls included respondents without ibs inflammatory bowel disease hrqol assessed via short form health survey version questionnaire summarized mental physical component summary mcs pcs scores short form dimension utility score work activity impairment assessed via work productivity activity impairment questionnaire general health version wpai measures absenteeism presenteeism overall work productivity loss daily activity impairment indirect costs calculated using unit cost data bureau labor statistics variables wpai generalized linear models used examine differences health outcomes respondents ibs controls controlling demographic health characteristics results total respondents ibs controls analyzed mean age years female compared controls ibs cohort reported significantly lower hrqol mean mcs mean pcs mean greater absenteeism presenteeism overall work productivity loss activity impairment respondents ibs also incurred estimated indirect costs conclusions compared controls ibs associated significantly lower hrqol greater impairments work daily activities higher indirect costs imposing substantial burden patients employers findings suggest significant unmet need exists effective ibs treatments
neural encoder one key components neuromorphic computing systems whereby sensory information transformed spike coded trains design temporal encoder attracted widespread attention field neuromorphic computing past years information temporal encoding scheme inter spike intervals arise correlations spike times could incorporated traditional rate encoding scheme paper propose robust energy efficient analog implementation spiking temporal encoder pattern neural activities across multiple timescales encode sensory information using time dependent temporal scales concept iteration structure introduced construct neural encoder greatly increases information process ability proposed temporal encoder integrated iteration technique operational amplifier free design error rate output temporal codes reduced extremely low level lower sampling rate accompanied additional verification spikes introduced schemes significantly reduces power consumption encoding system best knowledge proposed neuron circuit first analog hardware implementation neural encoder could present sensory data using inter spike interval temporal encoding scheme simulation measurement results show proposed temporal encoder exhibits energy efficiency also high accuracy
paper year meteorological data observed taipei taiwan studied investigate inherent correlation renewable resources data investigated time frequency space using wavelet analysis including wind speed global solar radiation air temperature wavelet transform time series related cross wavelet transform wavelet coherence phase angle obtained results show wavelet power spectra exhibit prominent oscillations annual half year periods three kinds meteorological data oscillations periods show regular pattern wind speed spectrum irregular two types data due climatic geographic factors whereas temperature regular form cross wavelet transform data pairs seen wind speed solar radiation anti phase correlation implying wind solar energy used complementary roles electricity generation region results wavelet analysis coincide variation trend monthly mean meteorological data year period wavelet analysis robust tool oscillation characteristic study time series data elsevier ltd rights reserved
increased interest sleep disorders patients inflammatory bowel disease ibd studies north america europe reported prevalence restless legs syndrome rls much higher patients crohn disease general population aim study reveal prevalence clinical features rls japanese patients ibd investigate influence rls sleep quality quality life qol study included outpatients ibd visited nagasaki university hospital december july patients completed international rls study group rating scale validated measure presence rls sleep quality assessed using japanese version pittsburgh sleep quality index psqi health related qol assessed using japanese version item short form healthy profile version prevalence rls patients ibd including rates patients ulcerative colitis patients among patients proportion women serum level crp higher rls group non rls group among differences clinical characteristics rls non rls groups patients rls group slept significantly less well non rls group psqi significant relationships observed qol indices presence rls physical score mental score role social score rls occurs frequently japanese patients well rls affects sleep quality qol considered one causes sleep disturbance patients ibd
star delta transformations popular electrical engineering late also tried reliability analysis techniques presented transform star delta delta star signal flow graph allows simplify non series parallel graphs using series parallel framework unlike case electrical circuits transformations always possible shown star delta transformation always possible delta transformed star certain loop condition satisfied important advantage techniques used even directed loops whereas case standard series parallel techniques
citrullination joint proteins protein arginine deiminase pad family enzymes recognized increasingly key process pathogenesis rheumatoid arthritis present study undertaken explore efficacy novel pad selective inhibitor gsk murine collagen induced arthritis model rheumatoid arthritis mice dosed daily time collagen immunization gsk efficacy assessed wide range end points including clinical disease scores joint histology immunohistochemistry serum joint citrulline levels quantification synovial autoantibodies using proteomic array containing joint peptides administration gsk led significant effects arthritis assessed global clinical disease activity histological analyses synovial inflammation pannus formation damage cartilage bone addition significant decreases complement deposition synovium cartilage observed robustly gsk neither total levels citrulline measurable joint serum levels circulating collagen antibodies affected significantly treatment gsk dose level contrast subset serum antibodies reactive citrullinated non citrullinated joint peptides reduced gsk treatment data extend previous demonstration efficacy pan pad inhibitor amidine demonstrate robustly pad inhibition alone sufficient block murine arthritis clinical histopathological end points
latinas experience multiple oppressions poorer mental health due often triple minority status poor female women color present study examined whether identifying mexican culture dominant culture bicultural high ethnic identity identifying feminine masculine behavior androgynous gender role perceiving greater family social support predicted life satisfaction positive affect low socioeconomic status mexican mexican american women results indicated greater ethnic identity greater perceived family social support significantly predicted mexican mexican american women life satisfaction greater ethnic identity greater feminine gender identity greater androgynous gender identity greater perceived family social support significant predictors positive affect furthermore expected social support family significant predictor life satisfaction positive affect implications results suggestions future research discussed
defect detection becoming increasingly important task manufacturing process early detection faults defects removal elements may produce essential improve product quality reduce economic impact caused discarding defective products point especially important case products expensive produce paper authors propose method detect specific type defect may occur production web materials periodical defects type defect harmful generate many surface defects greatly reducing quality end product occasions making unsuitable sale run proposed method two different functions must executed large number times since time available perform detection defects may limited important consume least amount time possible order reduce overall time required detection analysis method accesses input data performed thus efficient data structure store information determined end paper several experiments performed verify proposed method data structure used store information suitable solve aforementioned problem
aim study investigate usefulness three dimensional speckle tracking echocardiography ste assessment left right ventricular systolic function patients lymphoma anthracycline chemotherapy compared two dimensional ste totally eighty nine patients undergoing anthracycline containing chemotherapy studied echocardiographic assessment included left ventricular global longitudinal strain gls global circumferential strain gcs right ventricular gls parameters analyzed baseline completion four cycles end regimen respectively area receiver operating characteristic curve calculated determine capability various echocardiographic parameters discriminate chemotherapy compared baseline gls gcs gls decreased significantly four cycles therapy end treatment gls gcs deteriorated markedly area curve gls gcs gls derived respectively cutoff value gls sensitivity specificity differentiating patients therapy baselines cutoff value gls sensitivity specificity differentiating patients therapy baselines data study demonstrated ste conducted evaluate slight myocardial damage lymphoma patients anthracycline chemotherapy ste could examine subclinical biventricular dysfunction earlier point ste
recent years change biological effects tumor cells triggered nanoparticles become new breakthrough cancer therapy especially widely accepted various drug loaded nanoparticles induced tumor cell death encapsulating drugs depending epr effects enhance concentration drugs tumor sites nanoparticles useful new approach attracted increasing attention treat cancer fact nanoparticles also played important role tumor cell invasion metastasis used chitosan nanoparticles module explore internalization chitosan nanoparticles effects invasion metastasis tumor cells new finding demonstrated chitosan nanoparticles shown ability inducing reactive oxygen species believed significantly enhance cell invasion metastasis
use alternative project delivery methods design build construction manager risk cmar design construction water wastewater projects hindered several impediments existing owner organizations study identified impediments well possible solutions using delivery methods questionnaire designed sent utility managers wastewater owners water environment federation american water works association responses received results showed majority respondents representing states north america faced internal impediments unfamiliarity process resistance change within management policy officials delivery methods used addition respondents faced external impediments state procurement statutory requirements municipal agency procurement regulations recommendations based study include educating training decision makers policy officials project staff procurement legal staff regarding delivery methods changing state procurement rules
consuming healthy diet forms important component diabetes management however adhering healthy diet challenging dietary behaviour often guided socio cultural environmental emotional factors necessarily physical nutritional needs study explored nepalese patients perceptions impact diet diet management requirement diabetes nepalese food culture particular influenced diet management interviews conducted nepalese participants type diabetes sydney kathmandu data thematically analysed diet recognized cause key treatment modality diabetes besides doctors participants nepal received large amount dietary information community dietary changes formed major component lifestyle modifications adopted diagnosis mostly consisted removal foods added sugar foods high total sugar content diet reduction overall quantity foods consumed perceived dietary restriction requirements created social emotional discomfort patients participants perceived nepalese food culture barrier effective diet management meals high carbohydrates limited food choices food preparation methods identified barriers particularly nepal australia participants reported greater availability easier access appropriate food healthier cooking options socio cultural aspects food behaviour mainly food practices social events identified significant barriers although diet acknowledged important component diabetes care adopted changes diet post diagnosis effective sustained changes difficult achieve future public health campaigns education strategies focus improving diet knowledge awareness food options diabetes effective dietary management elsevier ltd rights reserved
work presents neutronics thermal hydraulics feasibility convert core westinghouse core performing parametric study varying type geometry pins fuel elements using heterogeneous seed blanket concept homogeneous concept parametric study geometry materials burnable poison kept variable fuel pin material usa several mass proportion uranium thorium keeping enrichment leu neutronics calculations made serpent code validate thermal limits used homemade code optimization criteria maximize conversion factor minimize plutonium production results obtained showed homogeneous concept three different mass proportion zones first containing tho second tho third tho using leu corresponding enrichment zones satisfies optimization criteria well attending thermal constrain concept showed advantages compared original core lower power density keeping months cycle reduction concentration soluble poison well eliminating integral boron poison coated ifba elsevier ltd rights reserved
moving object tracking one challenging problems computer vision numerous applications surveillance system traffic monitoring etc goal object tracking algorithm locate moving object consecutive video frames tracking moving object video becomes difficult due random motion objects paper introduces new algorithm moving object tracking exploiting properties daubechies complex wavelet transform zernike moment proposed method uses combination daubechies complex wavelet transform zernike moment feature object motivation behind using combination two feature object shift invariance better edge representation property make daubechies complex wavelet transform suitable locating object consecutive frames whereas rotation invariance properties zernike moment also helpful correct object identification consecutive frames therefore combination two feature object gives better results proposed method matches zernike moments daubechies complex wavelet coefficients object first frame next consecutive frames experimental results performance evaluation parameters validate proposed method gives better performance state art methods
objective purpose study determine cost effectiveness requiring recreational hockey players wear facial protection methods authors randomly surveyed recreational hockey players two indoor hockey rinks evendale ohio data collected face protection injuries demographic variables attitudes protective gear results surveyed players mean age years male average hockey experience years forty six percent respondents reported least one serious hockey injury last five years twenty four percent surveyed population chose wear face protection average cost face protection cost purchase two shields players would individuals face protection reported significantly sprains strains resulted significantly physician office visits specialty physician visits extra physician visits would add approximately people needing face protection face protection reported significantly fewer facial lacerations facial bone fractures requiring face protection prevent seven facial lacerations three facial bone fractures five years savings would approximately net savings requiring face protection would years population choosing wear face protection requiring face protection would save years person needing protection conclusion cost effective require facial protection recreational hockey players
inlet efficiency requirement characterizing flow transfers surface sewer flow rain events dual drainage approach based joint analysis upper lower drainage levels flow transfer one relevant elements define properly joint behaviour paper presents results experimental numerical investigation inlet efficiency definition full scale test platform located technical university catalonia upc reproduces runoff process streets water entering inlet data tests performed platform allow inlet efficiency estimated function significant hydraulic geometrical parameters reproduction tests numerical three dimensional code flow carried simulating type flow solving rans equations aim work reproduce hydraulic performance previously tested grated inlet several flow geometric conditions using flow virtual laboratory allow inlet efficiencies obtained without previous experimental tests moreover model allows better understanding hydraulics flow interception flow patterns approaching inlet
controlling moisture content self compacting concrete scc mixtures batching important assuring workability meeting design standards fluctuating situ aggregate moisture contents pose challenge measuring aggregate moisture every batch necessary inconvenient expensive hydraulic projects china study developed method estimating overall moisture scc mixture guide batch weight adjusting method includes laboratory based concrete test situ concrete mixing process overall moisture estimates determined slump flow values confirmed reliable verification experiments proposed method may serve alternative manual automated moisture measurement elsevier ltd rights reserved
context previous injury strongest risk factor future injury sports proposed motor control changes movement limitation asymmetry associated injury pain may perpetuated part individual movement strategy motor control fundamental body weight tasks reliably efficiently measured field objective determine whether motor control fundamental movement patterns pattern asymmetry relationship time loss injury course preseason professional football design injury risk study setting american professional football facilities participants american professional football players intervention measure motor control body weight fundamental movement patterns functional movement screen scores obtained start training camp previously established cutoff score presence asymmetries fms examined using relative risk determine relationship exists time loss injury main outcome measure time loss musculoskeletal injury defined time loss practice competition due musculoskeletal injury results players scored exhibited relative risk similarly players least asymmetry displayed relative risk combination scoring threshold exhibiting movement asymmetry highly specific injury specificity conclusion results study suggest fundamental movement patterns pattern asymmetry identifiable risk factors time loss injury preseason professional football players
high frequency gastrointestinal yeast presence asd subjects shown simple cultural approach candida spp asds controls identification aggressive form pseudo hyphae presenting candida spp light microscope means adhesion intestinal mucosa facilitated dysbiosis appears sustained lowered lactobacillus spp decreased number clostridium spp absence difficilis toxins asds controls also shown low mild gut inflammation augmented intestinal permeability demonstrated together presence symptoms significant linear correlation found disease severity cars score calprotectin clostridium spp presence also symptoms constipation alternating bowel correlate multivariate analyses increased permeability lactulose present data provide rationale basis possible specific therapeutic intervention restoring gut homeostasis asds
issue formulating ergun like equation applies dynamic beds previously considered tupper revisited using new high quality positron emission particle tracking data volume time averaged kinematic distributions granular glass beads slurry silica sand water mixture computed incorporating measured ingredients model reveals turbulence described usual effective viscosity nonetheless negligible new inertial cell equation first order spatial derivatives american institute chemical engineers aiche
human granulation intelligence means people observe analyze problem various granulation points view generally acknowledge essential feature human intelligence granulation view generate granular structure dividing cognitive target meaningful information granules means large number granular structures generated cognitive target however people group granular structures select representative ones problem solving leads interesting research topic efficiently effectively group family granular structures address issue first introduce granular structure distance measure difference two granular structures within unified knowledge representation propose framework grouping granular structures called ggs algorithm used efficiently partition moreover two indices denoted dis apd also designed evaluating performance grouping result granular structures finally experiments carried nine data sets show ggs algorithm comes sound solution perspectives convergence effectiveness scalability way proposed experimented general framework discovering structure inherent granular structures afterwards used simulate intelligent behavior human abilities granular structure selection elsevier inc rights reserved
first step rainwater harvesting system involves methods increase amount water stored soil profile trapping holding rain falls may involve small movements rainwater surface runoff order concentrate water wanted paper presents geographic information system gis methodology based decision support system dss uses remote sensing data filed survey gis delineate potential situ rainwater harvesting areas gis based dss implemented well evaluated existing rainwater harvesting structures study area input dss included map rainfall surplus slope potential runoff coefficient prc land cover use soil texture outputs map showing potential sites situ water harvesting iwh spatial distribution suitability map showed study area excellent good suitability iwh relatively area moderate suitability validation existing iwh structures done field survey using collected data suitability map validation depends comparing rainwater harvesting recharge dam locations generated suitability map location surveyed iwh structures using proximity analysis tool arcgis proximity analysis result exiting iwh structures categorized successful within good suitable areas
background although organizations comprehensive formal stress management programs approach likely helpful one curtailed specifically needs particular nursing unit aim mind process daily intensive care unit icu multidisciplinary operational debriefings developed operational debriefings use concepts traditional debriefing yet offered daily basis rather reserved major stressful events furthermore informal brief minutes multidisciplinary intensivists icu nurses chaplain icu social worker icu nutritionist icu pharmacist purpose descriptive study determine perceptions attendees relation implementation daily operational debriefings methods six months process attendees requested fill anonymous voluntary survey questions simple straightforward close ended results potential respondents nurses nurse managers social worker pharmacist nutritionist completed survey results revealed overwhelming majority felt daily operational debriefings provide effective unit based support system sense connectedness commitment well others nearly respondents felt overall stress level icu decreased indicated operational daily debriefings continue conclusion daily informal multidisciplinary icu operational debriefing provides effective support system icu nurses modified model could replicated non icu units well
introduction objective study assessment injuries occurred competitive rowing lifetime portuguese senior rowers material methods sent questionnaire portuguese senior rowers medalled national championships season analysed biometric variables anatomic location type circumstances injury occurrence type treatment provided time inactivity statistical analysis used parametric non parametric statistics confidence levels results questionnaire answered female male rowers females significantly lower ages heights weights rowed often sculling boats number years practice well number injuries per rower similar females males mean age first injury significantly lower females also progressive lesions acute ones although significantly frequent anatomical location type injury lumbar region muscular pathology higher occurrence winter spring land training females sustained longer periods inactivity significantly discussion results different reported authors may related differences studied populations factors need clarified conclusion injuries sustained portuguese competitive rowers probably associated lower competitive exposure athletes less severe generally reported literature
objective determine extent agreement cage acronym cut annoyed criticism guilty drinking eye opener drinks short michigan alcoholism screening test geriatric version smast identifying older persons may possible alcohol use disorders auds whether persons identified possible auds screening measures differ drinking demographic health related characteristics design secondary analysis cross sectional study using data self administered mailed survey sample setting three organizations surveyed members american association retired persons southern california managed care enrollees large medical group attendees community based senior health center participants one thousand eight hundred eighty nine persons aged older completing health risk appraisal older persons health risk appraisal elderly hra measurements hra included items drinking behaviors including amount alcohol use cage smast health demographic characteristics results twenty six percent persons screened positive cage smast fewer half persons screening positive either cage smast screened positive measures among cur rent drinkers persons screening positive smast alone drank less person screening positive cage alone persons drank less screening positive smast cage men screened positive oil cage alone smast alone conclusion fewer half persons screening positive either cage smast screened positive measures suggesting instruments may capturing different aspects unsafe drinking screening strategy employing brief measures may identify auds among older persons differing demographic health characteristics
background smoking well known public health problem women well men many countries including iran increase tobacco use among women exploring experience smoking educated women order develop effective tobacco prevention programs women necessary study aimed explore experiences smoking among iranian educated women methods study used method qualitative content analysis deep individual semi structured interviews sample educated female smokers selected purposefully data analyzed using qualitative content analysis conventional approach collected results data analysis led subcategories divided four main categories personal factors including subcategories imitation show independence inexperience curiosity personal interest desire improved mood social defiance family factors including smokers family intrafamily conflicts family strictures limitations social factors including subcategories effects work school environment gender equality symbols peer pressure acceptance among friends negative consequences smoking including subcategories sense physically hurt psychological emotional stress looked upon negative judgmental manner conclusions findings study showed smoking among iranian educated women multifactorial problem thus necessary address smoking among educated women holistic approach focuses different determinants including personal family social factors particularly gender roles stereotypes
given graph admits perfect matching investigate parameter eta originally motivated computer graphics applications defined follows among nonnegative edge weight assignments eta minimum ratio maximum weight perfect matching maximum weight general matching paper determine exact value eta rectangular grids bipartite cylindrical grids bipartite toroidal grids introduce several new techniques endeavor elsevier rights reserved
aim aim study quantify prevalence somatic pain paediatric emergency department methods conducted prospective observational study using patients admitted italian children hospital december february enrolled children aged turned complaining pain patients parents asked fill questionnaire allow analysis patients medical history provide contact details follow divided enrolled patients four groups post traumatic pain organic pain functional pain somatic pain questionnaire used define pain characteristics generate impairment score results patients met inclusion criteria enrolled study suffered post traumatic pain organic pain functional pain somatic pain somatic pain patients endured pain longer missed school days suffered severe functional impairment conclusion study highlighted somatic pain significant contributor paediatric emergency room visits suspected diagnosed children reporting pain
objective review summarize literature risk factors comorbidities consequences male hypogonadism defined syndrome complex includes biochemical confirmation low testosterone consistent symptoms signs associated low systematic literature search performed pubmed medline embase cochrane library articles published last years risk factors comorbidities consequences male hypogonadism relevant studies identified nine examined potential risk factors examined potential comorbidities examined potential consequences male hypogonadism based studies conducted asia australia europe north south america important factors predicted correlated hypogonadism advanced age obesity diagnosis metabolic syndrome mets poor general health status diabetes mellitus correlated hypogonadism studies established risk factor although diseases coronary heart disease hypertension stroke peripheral arterial disease predict hypogonadism correlate incident low data reviewed potential consequences suggest low levels may linked earlier cause cardiovascular related mortality among men literature review suggests men certain factors advanced age obesity mets poor general health likely develop hypogonadism low levels may important long term negative health consequences
finger vein recognition drawn increasing attention biometrics community due security convenience paper novel discriminative binary codes dbc learning method proposed finger vein recognition first subject relation graph built capture correlations among subjects based relation graph binary templates transformed describe vein characteristics subjects ensure templates discriminative representative graph transform formulated optimization problem distance templates different subjects maximized templates provide maximum information subjects last supervised information training instances provided obtained binary templates svms trained code learner bit compared existing binary codes finger vein recognition dbc discriminative shorter addition generated considering relationships among subjects may useful improve performance experimental results polyu database mla database demonstrate effectiveness efficiency dbc finger vein recognition retrieval
smart material using fibre bragg gratings fbgs embedded carbon fibre reinforced polymer simultaneous measurement physical parameters designed tested validated two fbgs embedded different sections composite sample one fully unidirectional bidirectional produced different sensitivities fbg sensor composite structure characterized strain temperature curvature temperature measurements experimental results compared agreed finite element simulations
background impact long term adjuvant therapy aromatase inhibitors als vertebral fracture risk still unclear objective cross sectional study explored prevalence determinants vfs breast cancer patients therapy woman underwent dual energy ray absorptiometry dxa evaluate bone mineral density bmd identify vfs quantitative morphometric approach blood samples collected measure serum hormone calcium levels results consecutively included postmenopausal women hormone receptor positive early one hundred sixty nine women naive treated treated patients lower bmd total hip lumbar spine higher serum vitamin parathyroid hormone values compared naive patients prevalence vfs naive patients assessed therapy odds ratio naive patients vfs associated older age lower bmd values femoral neck total hip whereas vfs occurred without association parameter analyzed treated patients treated group prevalence vfs significantly different patients osteoporosis normal bmd conclusions women early therapy associated high prevalence radiological vfs shown independent bmd values adjuvant treatment findings may clinically relevant since may lead change management induced skeletal fragility specifically results study provide rationale performing morphometric evaluation vfs women undergoing treatment als elsevier inc rights reserved
two new protocols quantum binary voting proposed one proposed protocols designed using standard scheme controlled deterministic secure quantum communication cdsqc one designed using idea quantum cryptographic switch uses technique known permutation particles possible alternative approaches accomplish task quantum binary voting also discussed security proposed protocols analyzed effciencies proposed protocols computed compared existing protocols comparison established proposed protocols efficient existing protocols
objectives prolactin prl lactation inducing hormone immunomodulatory properties found elevated levels serum patients rheumatic diseases prl receptor prlr shown expressed macrophages atherosclerotic plaques aim study examine prlr expression synovial macrophages role regulation macrophage activation methods serum monomeric kda prl levels measured patients using fluoroimmunometric assay prlr expression assessed synovial tissue psa patients immunohistochemistry digital image analysis double used identify prlr expressing cells effects prl monocyte derived macrophage gene expression examined quantitative real time pcr elisa results serum prl levels similar female male patients median interquartile range prlr expression significantly higher psa synovial tissue compared prlr colocalized synovial macrophages von willebrand factor endothelial cells vitro prlr prominently expressed ifn gamma polarized macrophages compared polarizing conditions prl negligible effects macrophage gene expression cooperated cdl tnf increase expression pro inflammatory genes including beta conclusions synovial prlr expression enhanced patients inflammatory arthritis compared prl cooperates pro inflammatory stimuli activate macrophages results identify prl prlr potential new therapeutic targets inflammatory arthritis
considering actual needs safety measures explosion accidents terrorist attacks large complex buildings numerical simulations explosions metro station studied paper three dimensional solid model metro station created eulerian three dimensional multi material parallel hydrocode pmmic proposed ning used simulate explosion shock wave propagation laws different conditions simulation models different reference positions set obtain attenuation laws pressure time curves explosion shock waves according numerical results range shock waves cause harm human health estimated based nato north atlantic treaty organization dod department defense specifications influences stairs pillars metro station explosive quality setting wall materials also taken consideration besides shock wave propagation pressure variation different conditions discussed addition prevention measures explosion scenario provided reduce damage human structures elsevier ltd rights reserved
etiology mechanisms inflammatory bowel disease ibd incompletely known determination new clinically important mechanisms intestinal inflammation imperative developing effective therapies treat ibd sought define widespread mechanism colon mucosal inflammation via activation tgf beta activated kinase tak central regulator cellular inflammatory actions activation tak downstream inflammatory signaling mediators determined pediatric patients ulcerative colitis crohn disease well dss induced spontaneous ibd mice role tak facilitating intestinal inflammation murine models ibd investigated using oxozeaenol highly selective pharmacological inhibitor tak found hyper activation tak patients murine models ibd pharmacological inhibition tak prevented loss body weight disease activity microscopic histopathology infiltration inflammatory cells colon mucosa elevated proinflammatory cytokine production two murine models ibd demonstrated early phase disease activation tak restricted epithelial cells however advanced stage disease tak activation predominantly occurs nonepithelial cells especially macrophages findings elucidate activation tak crucial promoting intestinal inflammation thus tak activation pathway may represent suitable target design new therapies treating ibd humans
work highly porous mos nanostructures synthesized via one pot versatile calcination cyanamide mos precursors first thermal polymerization cyanamide carbon nitride suppresses aggregation mos thermal decomposition formed carbon nitride brings plentiful pores size mos nanostructures generating extremely large specific surface area due high specific surface area abundant exposed edge sites resultant porous mos mos nanostructures exhibited outstanding electrochemical hydrogen evolution activity hso aqueous solution onset potential overpotential current density low similar similar respectively superior previously reported mos based electrocatalysts published elsevier
energy universal concept used across physical domains describe complex large scale industrial systems brief survey framework gives perspective energy unifying domain system modelling supervision control traditionally modelling control problems approached adopting signal processing paradigm however approach becomes problematic considering non linear systems behavioural viewpoint incorporates energy basis modelling control considered viable solution since energy seen unifying concept relationship euler lagrange equations state space representation lyapunov functions discussed connection control process supervision using passivity theory coupled system energy balance also established show complex industrial systems comprising multiple energy domains modelled means single electric circuit application large scale thermo hydraulic system presented next simple non linear transmission impedance electric circuit used illustrate energy used describe system also serve basis system optimisation energy based framework proposed whereby energy used unifying domain work analyse optimise large scale industrial systems
objective disclosure medical errors attracted considerable research interest recent years however research date lacked interdisciplinary dialog making translation findings medical practice challenging article lays disciplinary perspectives fields medicine ethics law communication medical error disclosure identifies gaps tensions occur interdisciplinary boundaries methods article summarizes discussion interdisciplinary error disclosure panel conference andrews scotland light current literature across four academic disciplines results current medical ethical legal communication perspectives medical error disclosure presented discussed particular emphasis interdisciplinary gaps tensions conclusion authors encourage interdisciplinary collaborations strive functional approach understanding improving disclosure medical errors ultimate goal improve quality promote safer medical care practice implications interdisciplinary collaborations needed reconcile needs stakeholders involved medical error disclosure particular challenge effective translation error disclosure research practice concrete research questions provided throughout manuscript facilitate resolution tensions currently impede interdisciplinary progress elsevier ireland ltd rights reserved
objectives consumption milk declining sharply recent decades particularly developed countries one reasons decline diagnosis perception lactose intolerance aim study investigate average consumption milk dairy products campania region italy one main producers dairy products country methods individuals aged living campania invited answer online questionnaire regarding average consumption milk dairy products questionnaire posted public access hospital site well several facebook pages friends hospital personnel results study found responders campania drink milk drink lactose free milk mainly gastrointestinal symptoms vast majority sample population chose avoid consuming milk without undergoing breath test lactose intolerance consulting doctor women underweight people drink lactose free milk milk containing lactose population sample avoid dairy products rather seem consumed quite frequently conclusion data support need mandatory implementation nutritional campaign increase understanding regarding example unnecessary avoidance milk excessive consumption cheese elsevier inc rights reserved
general synthesis procedure given versatile signal flow graph realization general current transfer function using multi output second generation current controlled current conveyors ccciis proposed configuration uses multi output second generation cur rent conveyors cciis capacitors resistors number resistors reduced special cases using ccciis instead cciis resistors removed completely nth order universal structure general transfer function numerator dynamics derived universal structure using single cccii resistors easy find values passive elements coefficients transfer function realized validity proposed synthesis verified pspice simulations elsevier gmbh rights reserved
paper presents approach design framework development metacognitive support system novice programmers mssnp learning introductory computer programming framework designed based tobias everson model metacognitive instruction consists planning selecting strategies evaluating learning knowledge monitoring following tobias everson metacognitive model three services models introduced framework follows knowledge monitoring model evaluation learning model metacognitive strategy selection model metacognitive activity processes mssnp take place learning instructional approach known cognitive strategy instruction csi also integral part framework five identified metacognitive activities specifically pre task familiarization production evaluation post task embedded within framework
ionospheric scintillation significant component space weather studies serves estimate level perturbation satellite radio wave signal caused due small scale ionospheric irregularities spline functions used gps ground based data collected year modeling high mid latitude ionospheric scintillation proposed model hornsund svalbard warsaw poland input data used model recorded gsv receivers validation results model compared observation existing models physical behavior ionospheric scintillation different seasons geomagnetic conditions discussed well model found good coherence ionospheric scintillation theory well accepted scintillation mechanism high mid latitude
aim study develop validate german adaptation dialectical behavior therapy ways coping checklist dbt wccl self report questionnaire measures frequency adaptive maladaptive skills used manage difficult situations past month adaptive skills derived dialectical behavior therapy dbt include dbt specific language assessed independent treatment patients borderline personality disorder completed german dbt wccl adaptation questionnaires assessing symptom severity different sample patients completed questionnaire five different time points undergoing inpatient dbt three factor structure english version replicated confirmed psychometric analyses indicated good internal consistency test retest reliability three subscales supporting construct validity measure skills use measured dbt wccl increased significantly inpatient dbt addition using skills significantly positively correlated prior experience dbt perceived use dbt skills conclusion results offer preliminary support validity reliability german adaptation dbt wccl
neonatal pain often undertreated based assumption immature nervous system lack myelinisation preterm newborn feel pain confirmed number articles fetus neonate experience respond painful events publication gives brief overview ontogeny pain short long term postnatal consequences well perception possibility particularly frail child population premature infants neonates based animal human studies
background skipping breakfast found associated abdominal obesity primary school children aim research examine factors associated skipping breakfast primary school children order develop targeted preventive measures methods baseline data assessment cluster randomized controlled trial evaluation school based health promotion program primary school children state baden wurttemberg germany anthropometric measures primary school children aged years boys conducted according isak standards international standard anthropometric assessment trained staff information health living conditions children parents assessed parental questionnaires generalized linear mixed regression analysis calculated define correlates skipping breakfast terms odds ratios confidence intervals results according final regression models significant correlates skipping breakfast divided modifiable behavioral components high consumption soft drinks screen media high levels physical activity one hand less static socio economic factors migration background single parenting high family education level hand finally individual factors female gender percentage body fat percentile conclusion targeted prevention aim health related behaviors accompanying habit skipping breakfast focusing vulnerable groups characterized easily modifiable socio economic well individual factors may improve results interventions synergistically promote children health involve parents order successful reach children avoid skipping breakfast schools offer regular breakfast start school day policy makers support healthy eating habits times
paper covers principal requirements design concepts implementation hardware software central board computer cdms philae lander context esa rosetta space mission including technical details focus implementation fault tolerance autonomous operation operational flexibility means specific linked data structures code execution mechanisms interpreted kind object oriented model mission sequencing iaa published elsevier ltd rights reserved
article authors present theoretical experimental studies gas burning devices chordal feed gas jets optimum diameter nozzles providing necessary range gas jets high quality mixing fuel gas air mixing chamber minimum length determined calculation analysis parameters flame indirectly proves reliability calculated data chordal flow gas jets optimization range significantly reduce overall structural dimensions gas burner units short flame gas burning devices formed basis creation autonomous heat gun intended repair maintenance engineering networks obtaining good heat gun ensured motor fan capable generating high pressure jet without connection external electrical network using autonomous heat gun housing communal services promising comparison similar devices published elsevier ltd
paper presents novel low power bandgap reference circuit bandgap reference adopts half period working mechanism operational amplifier work switched capacitor network sampling operational amplifier works charge balanced bandgap reference runs discontinuously design implements standard cmos process simulation result shows circuit consumes uaat noise circuit low frequency achieves root temperature coefficient ppm degrees
recent years great deal effort made create terahertz thz devices meta materials among devices perfect absorbers modulators highly desired thz system communication remote sensing imaging astronomy absorbers variety potential applications including thermal emitters detector stealth technology phase imaging high speed modulators allow actively control spatial transmission reflection incident thz wave key components advanced communication system presentation firstly introduce basic structure work principle devices report recent progress design fabrication measurement quite new devices close presentation demonstrate application devices terahertz communication system
coming described essential component lesbian gay bisexual identity development process mental health sexual minority people study investigated coming family members lesbian gay bisexual people analyzed potential predictors associated choice come purpose disclosure sexual orientation family members internalized sexual stigma evaluated adapted short version internalized sexual stigma lesbians gay men bisexual people measure internalized sexual stigma lesbians gay bisexual gender age sexual orientation background information current romantic relationship wealth social network sexual minority people assessed italian sample adolescents young adults lesbian gay men bisexual people hierarchical multiple regression showed higher scores coming family associated gay lesbian identity liberal political orientation higher education level presence stable romantic relationship higher number lesbian gay bisexual contacts lower levels internalized sexual stigma results suggest bisexual people encounter major difficulties regarding coming family members respect lesbian gay people indicate internalized sexual stigma strongly associated concealing one sexual orientation clinical implications present findings discussed
modular exponentiation time consuming operation widely used cryptography modular multi exponentiation generalization modular exponentiation also used cryptography deserves analysis algorithmic point view parallelization modular multi exponentiation obtained generalizing methods used parallelize modular exponentiation paper present new parallelization method modular multi exponentiation operation two optimizations first one searches fastest solution without taking account number processors second one balances load among processors finds smallest number processors achieves fastest solution detail algorithms compute product modular exponentiations split exponent blocks start threads thread processes together blocks different exponents thus block exponent processed different thread blocks different exponents processed together thread using addition chains show minimum number threads load balance optimal running time therefore algorithms optimized run minimum time minimum number processors elsevier inc rights reserved
study investigates multiple input buck converter different operational modes converter two three four input sources studied item relation critical inductance continuous conduction mode discontinuous conduction mode calculated finally generalised relationship proposed calculation critical inductance input topology true number input sources experimental simulation results power systems computer aided design emtdc presented validate theoretical concepts proposed generalised relation converter critical inductance
integrated electronic photonic phase locked loop pll modulates frequency tunable laser use frequency modulated continuous wave fmcw lidar imaging proposed lidar perform range measurements per second rms depth precision distances range baseline range window precision edges window optical circuitry including input light couplers waveguides photodiodes realized silicon photonic chip cmos asic area comprises frontend transimpedance amplifier analog electro optical pll digital control circuitry consuming supply supply latter includes bias current distributed bragg reflector section tunable laser two chips integrated using silicon vias implemented silicon photonic chip
terrain data processed double perspective computer graphics graph theory propose hybrid method uses geometrical vertex attribute information construct weighted graph reflecting variability vertex data planar graph generic terrain data set subjected geometry sensitive vertex partitioning procedure use combined thin plate energy multi dimensional quadric metric error feature estimation heuristic construct even odd node subsets using invertible lifting scheme adapted generic weighted graphs detail vectors extracted used recover filter node information design prediction update filters improves root mean squared error signal general graph based approaches key property design preserving mean graph signal becomes essential decreasing error measure conserving salient shape features
prior research shown difficulties emotion regulation associated overall levels posttraumatic stress symptoms ptss however currently unclear facets difficulties emotion regulation lack emotion regulation strategies impulse control problems non acceptance emotional responses associated specific ptss clusters information may valuable refining treatment approaches ptss aim current study use structural equation modeling test relationships difficulties emotion regulation scale ders subfactors ptss trauma exposed community sample results indicated impulse control difficulties consistently associated across ptss clusters experiencing avoidance hyperarousal lack emotion regulation strategies emotional clarity uniquely associated numbing symptoms covarying neuroticism however facets difficulties emotion regulation non acceptance emotional responses difficulties engaging goal directed behavior upset associated ptss findings provide support role difficulties emotion regulation specific ptss clusters additionally suggest impulse control problems may important development ptss thus beneficial target clinically lack emotional clarity effective emotion regulation strategies may specific numbing symptoms
alzheimer disease multifactorial disease wide clinical heterogenity overproduction amyloid precursor protein app accumulation beta amyloid beta tau proteins important hallmarks identification early pathomechanisms critically important discovery early diagnosis markers decreased brain metabolism one earliest clinical symptoms indicate mitochondrial dysfunction brain performed first comprehensive study integrating synaptic non synaptic mitochondrial proteome analysis two dimensional differential gel electrophoresis dige mass spectrometry correlation beta progression app mice months age identified changes mitochondrial proteins reflect progressive effect app overproduction beta accumulation mitochondrial processes significantly affected proteins play role mitochondrial electron transport chain citric acid cycle oxidative stress apoptosis altered expression levels htra ethe showed parallel changes different age groups confirmed also western blot common regulator bioinformatical analysis suggests regulatory role tumor necrosis factor tnf beta mediated mitochondrial protein changes results accordance previous postmortem human brain proteomic studies case many proteins results could open new path research aiming early mitochondrial molecular mechanisms beta accumulation prodromal stage human
paper presents design development fuzzy logic based multisensor fire detection system web based notification system recently consumer grade fire detection systems relied solely smoke detectors protection provided established limited type fire present detection technology use problem compounded lack adequate alert notification mechanisms typical system relies physical presence human act alert developing countries poor planning addressing negatively affects fire rescue crew response time address problem fuzzy logic system implemented using arduino development board inputs smoke sensor tmp temperature sensor dfrobot flame sensor output detection system sent short message service sms using sim global system mobile communication gsm module web based system house owner caretaker real time access granted web based system fire rescue crew also get notified real time location information comparison efficiency notification system employed standard fire detectors multisensor remote based notification approach adopted paper showed significant improvements form timely detection alerting response
chinese mapping satellite launched may provide wide swath remote sensing images stitching together subimages acquired panchromatic sensor pan however limited stitching precision caused particular configuration pan reduces geometric quality images restricts application letter propose new image space stitching approach based differential recursion optimal estimation filter pan images describe detail validate correctness advantages method experiments run several sets matching points different characteristics images different geographic conditions results show images seamless visual effect subpixel level stitching precision obtained
radiological features alone allow discrimination accidental paediatric long bone fractures sustained child abuse therefore clinical need elucidate mechanisms behind fracture provide forensic biomechanical tool vulnerable child four point bending torsional loading tests conducted one strain rate first time immature bone using specimen specific alignment system characterise structural behaviour para physiological strain rates bones behaved linearly point fracture cases transverse oblique spiral fracture patterns consistently reproduced results showed significant difference bending stiffness transverse oblique fractures four point bending torsional loading spiral fractures produced cases significant difference energy obliquity fracture multiple comminuted fractures seen bones failed higher stress torque loading types demonstrates differentiation fracture patterns different strain rates first time immature bones may used match case history given child fracture produced
lump type solutions rationally localized many directions space analyzed nonlinear differential equations derived generalized bilinear differential equations symbolic computations maple positive quadratic quartic polynomial solutions two classes generalized bilinear differential equations computed thus lump type solutions presented corresponding nonlinear differential equations generated taking transformation dependent variables
health promotion programs become increasingly common workplaces yet little research examined unintended potentially negative consequences initiatives overweight obese employees face widespread prejudice pervasive discrimination employment settings study investigates whether workplace health promotion may lead negative outcomes workers using experimental design author finds overweight obese employees rated negatively receive lower hiring recommendations evaluated companies health promotion programs findings suggest health promotion increases salience perceived legitimacy negative fat stereotypes facilitate weight based discrimination
widely used programming language developing embedded software operating systems device drivers unlike programs written managed languages like java programs rely explicit memory management therefore prone memory leaks existing static dynamic debugging tools report leaks fixing often requires considerable manual effort inspecting list reported true false alarms develop demand lightweight techniques automated leak fixing without introducing new memory errors remains challenging paper introduce autofix fully automated leak fixing approach programs combining static dynamic program analyses given leaky allocation site reported static memory leak detector autofix performs graph reachability analysis identify leaky paths value flow slices program conducts liveness analysis locate program points inserting fixes missing free calls identified leaky paths implemented autofix llvm evaluated using five spec benchmarks three open source applications experimental results show autofix safely fix memory leaks reported state art static memory leak detector small instrumentation overhead
article present compact implementation salsa stream cipher targeted towards lightweight cryptographic devices radio frequency identification rfid tags salsa stream cipher ann addition rotation xor arx cipher used high security cryptography neon instruction sets embedded arm cortex cpu core based tablets smartphones existing literature shows although classical cryptanalysis effective reduced rounds salsa stream cipher immune software side channel attacks branch timing cache timing attacks best knowledge work first perform hardware power analysis attacks evaluate resistance eight keywords proposed compact implementation salsa technique targets three subrounds first round implemented salsa correlation power analysis cpa attack attack complexity based extensive experiments compact implementation salsa demonstrate keywords recovered within queries salsa attacks show varying resilience key words cpa yet observed stream block cipher present literature makes architecture stream cipher interesting side channel analysis perspective also propose lightweight countermeasure mitigates leakage power traces shown results welch test statistics hardware area overhead proposed countermeasure designed compact implementation mind
purpose study determine bone health femoral neck lumbar spine predicted objectively measured sedentary behavior physical activity data postmenopausal women waist mounted actigraph gtm gtx devices used quantify levels sedentary moderate vigorous intensity behavior day period older females bone health normal osteopenia osteoporosis derived scores generated using dual energy ray absorptiometry binomial logistic regression analysis indicated sedentary time number breaks sedentary behavior significant predictors osteopenia osteoporosis adherence physical activity guidelines significant predictor bone health findings suggest frequent interruptions sedentary behavior associated improved bone health postmenopausal women
paper introduce pwnprd probabilistic threat modeling approach automatic attack graph generation based network modeling aim provide stakeholders organizations holistic approach provides high level overview technical details unlike many threat modeling attack graph approaches rely heavily manual work security expertise language comes built security analysis capabilities pwnprd generates probability distributions time compromise assets
development computer network technology network security issues also making people pay attention ipsec protocol viable solution communications security put forward many ipsec products also launched therefore detect mine possible vulnerabilities ipsec related products important necessary fuzzing test help find vulnerabilities ipsec product implementations current popular fuzzing tools peach widely recognized open source fuzzing framework however current peach unable support ike protocol paper achieved fuzzing test ike protocol extending framework peach
reduce noise emission fuel consumption aircraft taxiing airport powered wheel landing gear investigated experimentally theoretically configurations powered wheel driven hydraulic motor electric motor proposed historically roll friction transmission gear reducer transmission direct transmission adopted global environmental problem energy crisis prominent powered wheel becomes one focuses aviation industry paper reviewed background history current status powered wheel aircraft summarized research emphases development trend findings work showed powered wheels aircraft reduce noise emission fuel consumption aircraft airport remarkably driven directly wheel electric motors installed nose landing gears promising wheels
orbitofrontal cortex ofc involved emotional processing orbitofrontal abnormalities often observed various affective disorders thus chronic dysfunction ofc may cause symptoms affective disorders anxiety depression impulsivity previous studies investigated effect orbitofrontal dysfunction anxiety like behavior impulsive aggression rodents results inconsistent possibly reflecting different methods ofc inactivation studies used either lesion ofc may affect brain regions transient inactivation ofc whose effect may restored time reflect effects chronic ofc dysfunction addition study effect orbitofrontal inactivation depression like behavior rodents therefore present study examined whether chronic inactivation ofc continuous infusion gabaa receptor agonist muscimol causes behavioral abnormalities rats muscimol infusion inactivated ventral lateral part ofc following week ofc inactivation animals showed increase anxiety like behavior open field test light dark test impulsive aggression also augmented chronically ofc inactivated animals showed increased frequency fighting behavior induced electric foot shock hand chronic ofc inactivation reduced depression like behavior evaluated forced swim test additionally cause significant change corticosterone secretion response restraint stress data suggest orbitofrontal neural activity involved regulation anxiety depression like behaviors impulsive aggression rodents
since end rainwater harvesting rwh growing france first regulatory framework constituted mainly order august helped strengthen practice also introduced limitations development rwh considering growing social demand possible issues water resources likely first regulatory framework evolve order anticipate changes foreign case studies may instructive based detailed analysis eight countries continents germany united kingdom united states brazil india sri lanka australia uganda paper draws international overview rwh allowing french practices put perspective beyond specific sensitive differences experience countries gives useful lessons french case comparisons drawn different topics uses rainwater quality standards regulatory tools rwh development factors rwh especially urban areas appears france isolated topic necessary future better integrate overall urban water management approaches
objective determine effect biological mesh closure perineal wound healing extralevator abdominoperineal resection eapr background perineal wound complications frequently occur eapr preoperative radiotherapy rectal cancer cohort studies suggested biological mesh closure pelvic floor improves perineal wound healing methods patients randomly assigned primary closure standard arm biological mesh closure intervention arm non cross linked porcine acellular dermal mesh sutured pelvic floor remnants intervention arm followed layered closure ischioanal subcutaneous fat skin similar control intervention outcome randomization concealed patient perineal wound assessor primary endpoint rate uncomplicated perineal wound healing defined southampton wound score less days postoperatively patients followed year results total patients randomly assigned primary closure dropouts biological mesh closure dropouts uncomplicated perineal wound healing rate days evaluable primary closure significantly differ biological mesh closure relative risk confidence interval freedom perineal hernia year versus respectively conclusions perineal wound healing eapr preoperative radiotherapy rectal cancer improved using biological mesh significantly lower year perineal hernia rate biological mesh closure promising secondary finding needs longer follow determine clinical relevance
purpose study examine sleep patterns large sample infants toddlers ages birth months korea compare sleep patterns sleep problems sleep ecology parental behaviors global sleep data young children predominately asian predominately caucasian countries regions additionally examined parent child demographic information parental behaviors aspects sleep ecology predictors sleep patterns among infants toddlers korea parents caregivers korean infants toddlers completed expanded internet based version brief infant sleep questionnaire consistent studies sleep early childhood sleep wake patterns became increasingly consolidated older child age korea sample compared infants toddlers children korea latest bedtimes shortest total sleep daytime sleep durations least frequent rates napping even though half parents perceive children sleep problematic parental perceptions severe child sleep problems lowest within korea breastfeeding bottle feeding sleep resumption associated increased nocturnal awakenings evening television viewing associated later bedtimes may implications sleep hygiene recommendations clinical practice current study provides important information sleep wake patterns parental behaviors aspects sleep ecology infants toddlers physicians support healthy sleep korea
laparoscopic sleeve gastrectomy lsg demonstrated high long term effectiveness major advantages techniques objective study analyze changes physical fitness parameters morbidly obese patients months lsg conducted descriptive observational study month follow lsg patients evaluating changes body mass index bmi functional capacity min walking test hand grip strength manual dynamometry flexibility fingertip floor test balance flamingo test physical activity level international physical activity questionnaire ipaq perception general physical fitness international fitness scale ifis questionnaire anova revealed significant improvements bmi functional capacity flexibility balance physical activity level months improvement perception physical fitness cases significant changes found dominant hand non dominant hand dynamometry general physical fitness positively correlated bmi distance min test negatively correlated fingertip floor distance morbidly obese patients showed major improvements months lsg functional capacity balance mobility physical activity change grip strength improvements related better self perception general physical fitness
based lie symmetry analysis construct closed form solution kinematic part partial differential cosserat equations describing mechanical behavior elastic rods solution depends two arbitrary analytical vector functions analytical everywhere except certain domain independent variables one arbitrary vector functions satisfies simple explicitly given algebraic relation main theoretical result addition construction solution proof generality based observation hybrid semi analytical solver highly viscous two way coupled fluid rod problems developed allows interactive high fidelity simulations flagellated microswimmers result substantial reduction numerical stiffness
glutamate transporters eaat implicated drug addiction behavior determined whether eaat type eaat played role morphine addiction six eight week old eaat knockout eaat mice wild type littermates received intraperitoneal injections morphine alternative day induce conditioned place preference cpp two days place preference returned baseline mice received morphine induce reinstatement mice received intraperitoneal injection riluzole eaat activator min morphine saline injection hippocampus medial prefrontal cortex nucleus accumbens ventral tegmental area harvested western analysis last dose morphine injected morphine induced cpp wild type eaat mice gender statistically significant factor influence behavior conditioned behavior extinguished morphine administration stopped days wild type mice extinction occurred days discontinuation morphine injection eaat mice small dose morphine similarly reinstated conditioned behavior wild type eaat mice riluzole abolished morphine induced cpp initial place preference morphine increased eaat expression plasma membrane medial prefrontal cortex nucleus accumbens ventral tegmental area affect eaat expression hippocampus results suggest eaat delays extinction morphine induced cpp eaat activation may prevent formation morphine induced cpp ibro published elsevier ltd rights reserved
paclitaxel ptx bind human serum albumin hsa via hydrophobic interaction forming abraxane food drug administration fda approved effective antitumor nanomedicine drug herein effective antitumor drug ptx used induce self assembly hsa modified either photo sensitizer chlorin time serves chelating agent enable magnetic resonance imaging acyclic arg gly asp crgdyk peptide targets alpha beta integrin overexpressed tumor angiogenic endothelium two types tumor targeting theranostic nanoparticles constructed either coassembly hsa hsa rgd simultaneously forming hsa hsa rgd core shell structure assistance ptx induced albumin aggregation albumin based nanoparticles one hand could target alpha beta integrin evidenced vitro vivo experiments hand enable combined photodynannic chemotherapy offers remarkably improved therapeutic efficacy kill cancer comparison respective monotherapies work presents new type tumor targeted multifunctional albumin based nanoparticles drug induced self assembly rather simple method without sophisticated chemistry materials engineering promising multimodel imaging guided combination therapy cancer
novel intra cycle waste heat recovery icwhr methodology applied internal combustion engine presented study split type thermodynamic cycle design quasi isothermal compression charge air isobaric combustion air fuel mixture performed separately two chambers within design exhaust heat recovered intake air flow compression chamber combustion chamber consequently recovered energy utilized combustor directly intra cycle waste heat recovery process achieved investigate fundamental aspects new methodology comparative study conventional rankine based whr new icwhr undertaken theoretical numerical analysis applied evaluate performance characteristics two technologies icwhr cycle differs rankine cycle energy conversion subsystem necessary since recovered energy sent back combustion chamber directly system efficiency improved significantly furthermore theoretical results indicate full cycle efficiency icwhr system determined regeneration effectiveness compression ratio fuel equivalence ratio limitations rankine cycle working fluid selection system parameter calibration avoided mechanically finally one dimensional system model analysis optimal operation range system efficiency heat transfer behaviours icwhr system discussed paper comparisons made rankine cycle whr system authors published elsevier ltd open access article license
recollection currently modeled univariate retrieval process memory probes provoke conscious awareness contextual details earlier target presentations however conception explain manipulations increase recollection recognition experiments suppress false memory false memory experiments whereas others increase false memory contrasting effects explained recollection bivariate memory probes provoke conscious awareness target items per separately awareness contextual details false memory suppressed former increased latter interestingly conceptions recollection coexisted time different segments memory literature independent support dual recollection hypothesis provided surprising effects predicts release recollection rejection false persistence negative relations false alarm rates target remember know judgments recollection without remembering implemented hypothesis bivariate recollection models differ degree recollection treated discrete graded process pure multinomial model pure signal detection model mixed multinomial signal detection model models applied large corpus conjoint recognition data fits satisfactory recollection processes present unsatisfactory either deleted factor analyses models parameter spaces showed target context recollection never loaded common factor models converged process loci effects important experimental manipulations thus variety results consistent bivariate recollection
freshwater resources scarcity becoming limiting factor development sustenance parts ethiopia debre mewi watershed northwest ethiopia one areas need supplemental water supply rainwater harvesting essential suitable water harvesting sites identified overlay analysis considering social technical parameters land use land cover slope gradient soil texture flow accumulation stakeholders priority performed integration gis remote sensing applications knowledge runoff resulting rainfall important designing water harvesting structure direct field level measurement runoff always good time consuming labour intensive expensive conditions direct measurement runoff could possible remote sensing technology gis combined runoff models proven effective study remotely sensed satellite data quickbird provided spatial information land use land cover precipitation obtained nearest meteorological station soil data acquired form laboratory analysis gis tools used store manipulate estimate runoff depth surface storage runoff volume applying soil conservation service scs curve number formula direct runoff volume estimated using scs model month august debre mewi watershed covers result compared measured values closer relationship found indicates enough runoff water harvested different uses remote sensing found important tool providing input parameters gis also found important tool mapping integrating different variables process runoff estimation suitable water harvesting sites selection
objectiveto compare risk discontinuation ambulatory antipsychotic treatment persons treated antipsychotic long acting injections lais oral antipsychotics oaps methodsthe study performed representative sample persons newly treated oaps affiliated french insurance healthcare system risk cause discontinuation compared patients prescribed oaps matched patients prescribed lais using multivariate survival analyses confounding indication minimized matching type antipsychotic drug high dimensional propensity score method resultsdiscontinuation frequent oaps compared lais adjusted relative risk arr risk discontinuation higher first generation fga oaps fga lais arr well second generation sga oaps sga lais arr month period discontinuation lais new antipsychotic drug dispensed patients frequent pattern dispensing lai prescribed discontinuation conclusionsalthough less frequent oaps rate ambulatory treatment discontinuation high lais prescription lais associated intervention strategies aimed promoting medication adherence
nanohub org open access cyberinfrastructure supported national science foundation provides powerful versatile platform delivering computational resources support implementation integrated computational materials engineering icme solutions associated educational efforts nanohub provides free cloud scientific computing users access simulation tools research education using web browser ipad without need install software access local computing resources tools friendly fully interactive graphical user interfaces meaningful default values output numerical data visualizations extensive support material provides accessible pathway towards advanced materials simulations back end nanohub computational resources include high performance computing clusters enable research quality simulation nanohub platform empower icme researchers educators two distinct ways using existing tools creating publishing new customized nanohub tools existing nanohub tools currently used introduce icme simulations courses variety areas electronic structures diffusion kinetics mechanics materials tools created installing available open source code nanohub building custom graphical user interfaces guis using rappture toolkit rapid application infrastructure http rappture org integrated nanohub workspace similar manner instructors install simulation tools nanohub using rappture easily customize tools meet learning objectives paper introduces existing nanohub icme tools additional resources materials science education procedure customizing publishing new simulation tools nanohub
background aim study evaluate efficiency adverse effects pharmacoeconomic impact empirical preemptive antifungal therapy febrile neutropenic hematological malignancy patients china material methods patients febrile neutropenia hematological malignancy randomly divided empirical group preemptive group preemptive antifungal treatment initiated patient status confirmed clinical manifestation imaging diagnosis beta glucan testing galactomannan test treatment ended weeks later patient recovered neutropenia voriconazole used first line medicine patients received intravenous administration voriconazole every initiating dose dose reduced results overall survival rate empirical group preemptive group respectively significant difference observed chi however occurrence rate invasive fungal disease ifd preemptive group empirical group moreover mortality rate due ifd empirical group preemptive group respectively average duration cost preemptive antifungal therapy days rmb respectively lower empirical therapy however significant differences observed incidence adverse effects hospital stay groups conclusions preemptive antifungal therapy patients febrile neutropenic hematological malignancy demonstrated similar survival rate empirical therapy economically favorable chinese population
transition sustainable economy inevitable population consumption continue grow ecosystems decline result increased business activity resources stretched limit survival businesses much dependent ability adapt transition business model addresses important sustainability megaforces climate change energy fuel material resource scarcity water scarcity population growth urbanisation wealth food security ecosystem decline deforestation research identifies megaforces important construction industry sector examines level preparedness australian construction companies responding megaforces also identifies value drivers behind megaforces content analysis recommendations provided construction companies develop resilience remain competitive future paper interest construction management sustainability practitioners
individuals employment experience stress work numerous epidemiological studies documented negative health effects particularly cardiovascular disease cvd although evidence various interrelationships work stress cvd accumulated observations yet conceptualized terms life course perspective using chain risk model would like propose theoretical model incorporating six steps work stress increases risk incident cvd healthy workers among whose work ability fully permanently damaged work stress acts determinant process return work cvd onset cvd patients experience higher work stress return work work stress increases risk recurrent cvd workers prior cvd cvd patients fully lose work ability transit disability retirement disability retirees due cvd elevated risk cvd mortality life course perspective might facilitate depth understanding diverse interrelationships work stress cvd thereby leading work stress management interventions period lifespan three level prevention cvd
present billd modern efficient package classical simulations two dimensional hamiltonian systems billd used various billiard diffusion problems one charged particles interactions different external potentials external magnetic field periodic open boundaries etc software package also calculate many key quantities complex systems poincare sections survival probabilities diffusion coefficients aiming large class applicable systems code also strives ease use efficiency modularity implementation additional features package comes along user guide developer manual documentation application program interface api program summary program title billd catalogue identifier aeylv program summary url http cpc qub summaries aeylv html program obtainable cpc program library queen university belfast ireland licensing provisions gnu general public license version lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language computer tested architectures operating systems tested linux versions code vectorized parallelized shared memory parallelization simulating ensembles systems vectorization operations vectors ram simulation dependent kilobytes gigabytes classification external routines boost cmake gsl hdf optionally google mock googletest doxygen nature problem numerical propagation classical two dimensional single many body systems possibly magnetic field calculation relevant quantities poincare sections survival probabilities diffusion efficients etc solution method symplectic numerical integration hamilton equations motion cartesian coordinates solution newton equations motion magnetic field program implements several well established algorithms restrictions pointlike particles equal masses charges although latter restrictions easy lift unusual features program efficient extremely modular easy extend allows arbitrary particle particle interactions additional comments source code also available https bitbucicet orgisolanpaa billd see readme locations user guide developer manual api docs running time milliseconds days depends type simulation elsevier rights reserved
medial elbow injuries throwing athlete common increasing frequency occur due repetitive supraphysiologic forces acting elbow overhead throw overuse inadequate rest salient risk factors injury athletes improve substantially rest nonoperative treatment although athletes may require surgical intervention return play advances conservative surgical treatments outcomes medial elbow injury improved time currently athletes able return high level play ulnar collateral ligament reconstruction experience low rate complications
present study aimed investigate potential gene markers predicting formation carotid atheroma plaques using high throughput bioinformatics methods gse gene expression profile downloaded gene expression omnibus database following data processing differentially expressed genes degs screened using paired test linear models microarray data package criteria false discovery rate followed functional enrichment protein protein interaction ppi network construction key node module analysis prediction transcription factors tfs targeting genes significant modules results revealed gene expression profiles paired samples carotid atheroma plaque tissue macroscopically intact tissue obtained based degs including upregulated genes downregulated genes identified upregulated downregulated gene sets enriched pathways respectively ppi network constructed degs comprised key nodes degrees among spleen tyrosine kinase syk lyn phosphatidylinositol bisphosphate kinase catalytic subunit gamma pikcg three highest significant module mined ppi network consisted degs targeted tfs degs carotid atheroma plaque macroscopically intact tissue samples may involved carotid atherogenesis key nodes ppi network constructed degs genes involved significant module including syk lyn pikcg promising prediction carotid plaque formation
biological materials proteins often hierarchical structure ranging basic building blocks nanoscale amino acids assembled structures macroscale fibers current software materials engineering allows user specify polypeptide chains simple secondary structures prior molecular dynamics simulation flexible terms geometric arrangement unequilibrated structures given knowledge larger scale structure instructing software create difficult time intensive end present paper reports mathematical language using category theory describe architecture material set building blocks instructions combining framework applies hierarchical material concentrate proteins implement mathematical language open source python library called matriarch domain specific language gives user ability create almost arbitrary structures arbitrary amino acid sequences generate protein data bank pdb files way matriarch powerful commercial software available matriarch used tandem molecular dynamics simulations helps engineers design modify biologically inspired materials based desired functionality case study use software alter building blocks building instructions tropocollagen determine effect structure mechanical properties
objectives study assess prevalence anxiety stress indian women evaluate relationship occupation prevalence anxiety stress cross sectional study performed january june women aged years randomly selected different occupations gujarat india anxiety evaluated using spielberg state trait anxiety inventory scale stress assessed using international stress management association questionnaire serum cortisol concentration measured sub sample association occupation stress anxiety analyzed generalized linear model adjusted age among participants prone somewhat prone stress women showed high anxiety levels homemakers times higher anxiety times higher stress working women prevalence stress occupation study revealed high prevalence rates stress anxiety indian women involvement activities outside home may help women reduce stress
evaluate concurrent validity promis pediatric global health measure pgh child report parent proxy versions surveys administered via home computer two separate occasions december august september convenience sample children years old parents participated national internet panel data analysis included evaluations differences pgh scores groups defined sociodemographics clinical characteristics access health care associations promis pediatric measures correlations two health related quality life instruments kidscreen pedsql pgh scores lower children chronic conditions hispanic ethnicity low socioeconomic status barriers accessing health care pgh showed excellent convergent discriminant validity promis pediatric measures physical mental social health pgh strongly correlated kidscreen assesses positive health moderately correlated pedsql assesses problems child health pgh measures global health summarizing child physical mental social health single score properties make useful clinical population health research tool applications require efficient precise valid summary measure children self reported health status future research prospectively evaluate pgh capacity detect change results alterations clinical status transformations healthcare delivery system children health development
regression testing performed see changes introduced software affect rest functional software parts inefficient execute test cases every time changes made regard test cases prioritized following criteria perform efficient testing meeting limited testing resources research proposed value based particle swarm intelligence algorithm test case prioritization aim research detect maximum faults earlier testing life cycle introduced combination six prioritization factors prioritization factors customer priority requirement volatility implementation complexity requirement traceability execution time fault impact requirement combination factors used prioritization controlled experiment performed three medium size projects compared results random prioritization technique results analyzed help average percentage fault detection apfd metric obtained results showed proposed algorithm efficient robust earlier rate fault detection results also revalidated proposing new validation equation showed consistent improvement proposed algorithm
brief presents ultra low power low noise chopped capacitively coupled instrumentation amplifier ccia suitable neural recording applications active high pass filter embedded ripple reduction loop rrl suppress residual noise relax capacitor size multiple chopping employed reduce residual output ripple due rrl offsets servo loop dsl using pseudofeedback amplifier proposed achieve subhertz high pass corner using chip capacitor complete ccia implemented standard cmos process occupies area including dsl consumes froma supply achieving noise efficiency factor compares favorably state art
retrospective investigation examined association among childhood bullying victimization multiple forms victimization psychological functioning college sample four hundred eighty two undergraduate students participated study years sample included women race ethnicity european american african american grade level freshmen followed sophomores juniors seniors participants completed survey packet measures assessing childhood bullying victimization experiences current levels psychological functioning findings indicated bullying victimization significantly predicted greater levels depression anxiety post traumatic stress pts controlling childhood victimization experiences pts symptoms predicted exposure community violence child abuse bullying victimization found strongest predictor college level practitioners need assess wide range childhood victimization experiences including bullying victimization
online social networking sites snss gained increasing popularity last decade individuals engaging snss connect others share similar interests perceived need online may result compulsive use snss extreme cases may result symptoms consequences traditionally associated substance related addictions order present new insights online social networking addiction paper lessons learned concerning online social networking sites addiction based insights derived recent empirical research presented social networking social media use social networking eclectic iii social networking way individuals become addicted using social networking sites facebook addiction one example sns addiction fear missing fomo may part sns addiction vii smartphone addiction may part sns addiction viii nomophobia may part sns addiction sociodemographic differences sns addiction methodological problems research date discussed turn recommendations research clinical applications provided
relativistic ethical position rejects possibility relying universal moral norms draw conclusions moral judgments influence moral behavior particulary prosociality penalization faults crimes empathy important mediating role objective present paper test interaction variables model using sem relativism moral absolutism predictor variables empathy variable mediator prosocial behavior penalization faults crimes dependent variables variables measured sample adolescents years age mean age males females belonging province entre rios buenos aires argentina results indicated good fit proposed model empirical data obtained following adjustment indexes also obtained gfi agfi cfi absolutism predictor variable positive effect penalization crimes faults positive effect increased empathy mediating variable variables relativism negative effect penalization faults crimes results proposed theoretical model confirm importance relativism moral absolutism penalization faults crimes prosocial behavior important mediating role empathy concretion moral
area topographic factors landfill site slope angle becomes steeper makes much disposal capacity tensile force geotextile caused compaction work disposed waste tensile force transferred liner system friction tensile force liner system change change slope angle important determine amount tensile forces creating fixed ends liner system avoiding tearing failure liner system designing anchorage paper fem analyses joint element used model interface liner system conducted estimate tensile forces creating fixed ends liner system change slope angle analysis results show tensile forces creating fixed end liner decrease slope angle increases
nine platinum complexes monoalkyl dach derivatives carrier ligands demethyl cantharidate leaving group synthesized spectrally characterized complexes showed considerable cytotoxicity tested human cancer cell lines hct hepg mcf cell lines especially complex exhibited potent cytotoxicity hct cell lines showed cross resistance cisplatin sgc cddp cell line addition typical compounds studied flow cytometric analysis western blot method results indicated induced apoptosis mitochondrial dependent pathway similar cisplatin elsevier rights reserved
paper presents transformation nonlinear electric circuit linear one changing coordinates local diffeomorphism use closed feedback loop necessary conditions must fulfilled nonlinear system enable carrying linearizing procedures presented numerical solutions state equations nonlinear system equivalent linearized system included
purpose work investigate new nano additive improved internal combustion engine oils designed increased fuel economy cleaner environment friction wear characteristics nano lubricants containing hybrid nano materials alo tio evaluated reciprocating test conditions simulate piston ring cylinder liner contact alo tio nanoparticles suspended commercially available lubricant various concentrations alo tio nanoparticles sizes respectively morphology microstructure tribofilms produced frictional contact investigated via sem eds surface profiler best case reduction frictional power losses simulated piston ring assembly compared commercially available lubricant nano additive composition case alo tio moreover wear rate piston ring decreased sliding due delamination alo tio nanoparticles worn surfaces case acted solid lubricant reduce wear scuffing results present promising straightforward approach automotive fuel economy increased life span engine parts elsevier rights reserved
paper devoted dynamical behavior stochastic extensible suspension bridge equation white noise deterministic suspension bridge equation many classical results existence uniqueness solution long term behavior solutions best knowledge existence attractors suspension bridge equation white noise yet considered intend investigate problems first obtain dissipativeness solution higher energy spaces omega omega boolean omega implies random dynamical system generated equation random attractor omega boolean omega omega tempered random set space omega omega boolean omega elsevier ltd rights reserved
wide swing optical modulator driver implemented sige bicmos using three stage distributed amplifier digital input line measurements demonstrate differential output symmetric min rise fall times rms additive jitter better output return loss ghz full output swing adjustable rise fall times realized three step calibration sequence facilitated chip energy detector digital control circuit supports external data sources prbs internal data generators calibration characterization respectively driver active area consumes supplies
paper presents new memristor emulator circuit circuit built around current feedback operational amplifier exploits nonlinear transfer characteristic operational transconductance amplifier provide continuous change memresistance contrast many available memristor emulators provide binary memresistance levels moreover emulator enjoys low impedance input suitable current driving rather voltage driving functionality proposed memristor emulator confirmed implementing well known reactance less multivibrator circuit experimentally obtained results included elsevier gmbh rights reserved
background aim study evaluate feasibility effects intemet based information self help program therapist contact parents children adolescents burns program aimed reduce parents symptoms general posttraumatic stress methods participants parents children treated burns either two specialized swedish burn centers sixty two parents included two armed randomized controlled trial six week intervention group wait list control group including pre post assessment well month follow intervention contained psychoeducation exercises homework assignments intervention group received weekly written feedback therapist main outcome stress post traumatic stress general stress parental stress results program beneficial effect posttraumatic stress short term affect general stress parental stress parents rated program informative meaningful thought time consuming conclusion program potential support parents children burns intervention easily accessible cost effective could implemented bum care rehabilitation author published elsevier ltd
objectivethe present trial evaluated incorporation bright light therapy treatment chronic nonspecific back pain cnbp designa prospective randomized controlled multicenter open design three parallel trial arms used settingsubjects received novel therapeutic expected therapeutic ineffective low dose light exposure three different medical centers patientsa total cnbp patients reporting pain intensity points item brief pain inventory bpi included interventionover weeks active treatment placebo controls controls received supplementary light exposures respectively outcome measureschanges self reported scores pain intensity bpi sub score depression hospital anxiety depression questionnaire primary outcome measures secondary outcome measures changes self reported overall pain sensation bpi total score grade everyday life impairment bpi sub score mood visual analog scale well world health organization five well index resultschanges pain intensity higher bright light group compared controls effect size changes depression score also higher intervention group compared controls effect size differences seen change scores intervention sham group conclusionthe present randomized controlled trial shows light therapy even low dose could improve depressive symptoms reduce pain intensity cnbp patients research needed optimizing parameters frequency dose duration therapeutic light exposure
paper presents study leading new acute toxicity test embryonic juvenile organisms great pond snail lymnaea stagnalis linnaeus sulfuric acid nitric acid ammonium hydroxide used waterborne toxicants laboratory experiments exposure time tests conducted replications toxicant toxicity substances classified according different scales test sensitivity compared commonly used bioindicator daphnia magna straus assessment toxicity impact supported microscopic observations probit method used parametric statistical procedure estimate associated confidence interval study showed early developmental stages lymnaea stagnalis sensitive bioindicators making possible detect even low levels mentioned water toxicants highest toxicity shown ammonium hydroxide values respectively embryos juvenile forms lowest shown nitric acid ions values respectively embryos juvenile forms highly cost effective due simple efficient breeding small size organisms bioassay population compared daphnia magna relatively low concentrations toxicants caused lethal effect embryonic juvenile organisms great pond snail owing common occurrence sensitivity early developmental forms lymnaea stagnalis valuable new tool biomonitoring freshwater environment
background deepening research roles lncrnas play fibrotic process attracted great attention early stage pancreatic fibrogenesis effectively regulate pancreatic stellate cells pscs activation crucial treatment chronic pancreatic fibrosis methods microarray data chronic pancreatitis retrieved gene expression omnibus geo repository analyzed using bioinformatic methods diagram lncrna mirna mrna cerna network constructed addition activated rat pscs transfected small interfering rna sirna targeting syntaxin stx lncrna expression stx mir mir examined pcr expression interleukin signal transducer ilst smad family member smad alpha smooth muscle actin alpha sma proteins examined western blot expression alpha sma examined immunofluorescence staining results based results bioinformatic analysis lncrna mirna mrna network established number putative cerna pairs regulating activation pscs identified including stx lncrna mir mir smad ilst expression stx downregulated relative expression level expression mir significantly elevated relative expression level expression mir markedly reduced relative expression level expression smad decreased relative expression level whereas expression ilst displayed significant change additionally expression sma dramatically reduced relative expression level immunofluorescence analysis confirmed alpha sma expression decreased cells conclusion pscs activation chronic pancreatitis existence cerna interactions pancreatic fibrosis demonstrated regulation stx mir smad axis may serve new gene therapy strategy treatment chronic pancreatitis reversal pancreatic fibrosis iap epc published elsevier rights reserved
population sizes ice associated pinnipeds often estimated visual photographic aerial surveys methods require relatively slow speeds low altitudes limiting area cover recent developments infrared imagery integration digital photography could allow substantially larger areas surveyed accurate enumeration individuals thereby solving major problems previous survey methods conducted trial survey april estimate number pacific walruses odobenus rosmarus divergens hauled sea ice around lawrence island alaska survey used high altitude infrared imagery detect groups walruses strip transects low altitude digital photography used determine number walruses sample detected groups calibrate infrared imagery estimating total number walruses propose survey design incorporating approach satellite radio telemetry estimate proportion population water additional low level flights estimate proportion hauled population groups small detected infrared imagery believe approach offers potential obtaining reliable population estimates walruses ice associated pinnipeds
west coast taiwan belongs alluvial plain rich sediment delivery early stage based river sediment transport sea wave wind affected huge amount sediment deposited river outlet sea coupled longshore sediment transport resulted gradually formation many small barrier islands along coast passage time sediment deposition thus formation watershed called lagoon inside sea lagoon connectivity within outside sea inlets made inside sea water exchanged outside sea water refreshing water quality also enriching ecosystem port facilities construction light active increasing demand marine transit international trading business coupled upper stream reservoirs construction stream sand gravel mining create river sediment transport declining directly impact coastal change erosion problem barrier islands tainan coast seriously eroded decrease elevation gradually loss natural flood detention function ecology fishery resources lagoon face threats coastal areas occurrence flooding barrier islands shift land make lagoon serious siltation elevation decreasing barrier islands make new inlets whenever typhoons pass tidal current velocities changes due tidal movement make loss barrier island also expand width inlet project restore barrier islands wangye port beimen tainan construct changes traditional beach nourishment construction method applying geotextile tubes donated ace geosynthetics barrier islands locate south side chishui river outlet sea total length comprehensive erosion situation beimen coastline width beach disappear north wangye port average annual erosion year sea meteorological wangye port average tidal range average wave height year return period storm wave height similar width inlet becomes half year velocity inlet traditional sand fixed hedge sand dune vegetation engineering method resolve issue enlargement inlet coupled tidal current velocity tidal change inlet restoration work must race time avoid new inlet formation due necking effect inlet containment past people used geotextile bag volume implement restoration engineering low strength less weight caused damage typhoon attacked present suggest using geotextile tube circumference length weight times original sandbag also efficient construction method horsepower dredge boat inch hdpe sediment transport pipes link geotextile tube inch hose long geotextile tube installation completed within two hours sediment transport efficient installation geotextile tube bamboo piles side geotextile tubes backfill sand total duration one month result backfill area reached total filling volume sand source lagoon construction period due inlet width gradually reduced seaward side beach significant sediment deposition phenomenon lagoon known natural protective barrier call marine reservoir inlet closed completely solve barrier island shift land caused inside sea siltation barrier islands play natural detention flood prevention disaster function results corroborate geotextile tube applicable solving lagoon siltation inlet closed also offers speedy friendly solution deal environmental reinforcement barrier island without effecting livelihood fishermen oyster farmers
medical image segmentation requires consensus ground truth segmentations derived multiple expert annotations novel approach proposed obtains consensus segmentations experts using graph cuts semi supervised learning ssl popular approaches use iterative expectation maximization estimate final annotation quantify annotator performance techniques pose risk getting trapped local minima propose self consistency score quantify annotator consistency using low level image features ssl used predict missing annotations considering global features local image consistency score also serves penalty cost second order markov random field mrf cost function optimized using graph cuts derive final consensus label graph cut obtains global maximum without iterative procedure experimental results synthetic images real data crohn disease patients retinal images show final segmentation accurate consistent competing methods
hiv hiv closely related retroviruses differences pathogenicity geographic distribution hiv infection associated slower disease progression transmission longer latency period low undetectable plasmatic viral loads reduced likelihood progression aids compared hiv investigation analyzed hiv genes genomes compared hiv belonging various subtypes comparative analysis effective number codons enc nine genes two viruses revealed tat gene hiv higher enc value compared hiv tat reflecting lower levels expression hiv tat lower levels tat protein particularly early stages infection could result lower viral load lower viral set point delayed progression disease hiv infected individuals compared hiv infected subjects furthermore composition regulatory genes hiv suggesting firm effort viruses adapt evolutionary survival hypothesize differential codon usage could one possible factors could contribute diminished pathogenicity hiv host compared hiv
paper fuzzy controller applied variable speed drive use direct coupled photovoltaic pumping systems proposed fuzzy logic system used mandani type embedded microcontroller corresponds proportional derivative controller low power module used detected variations irradiance incident array experimental tests performed using motopump testing workbench able simulate water wells different manometric heights results show fuzzy controller capable operating system continuously throughout day average efficiency
paper presents sub threshold bulk driven two stage cascode compensated operational transconductor drive load input core first stage uses bulk driven source degenerated gate regenerated class flipped voltage follower fvf ensures rail rail linear input signal drive capability unity gain configuration self cascode load input stage followed common source second stage simple current source load enhanced overall gain around mhz instead miller compensation cascode compensation implemented using two capacitors value ota increased phase margin gain bandwidth compared miller compensation identical load total compensation capacitors ensured better rail rail linearity thd frequency consuming around power dual power supply another three stage ota also proposed includes one additional class buffer output ota drive shunt load buffered ota additionally nested miller compensated using capacitor nmc buffering enhances slew rate gain bandwidth gbw two times compared buffered structure cost power cadence virtuoso environment using umc cmos process technology used simulate proposed circuits elsevier ltd rights reserved
article highlights significant health impact falls among older adults emphasis placed vital role pharmacist regardless practice setting assessing reducing falls risk growing population addition importance stepwise comprehensive approach falls assessment pharmacists collaboration clinicians elucidated
purpose thyroid dysfunctions related anovulation miscarriages infertility women laboratory animals mechanisms associated effects unknown although indirect direct actions thyroid hormones thyrotropin could assumed present study aimed identify distribution thyroid hormones trs thyrotropin tshr receptors reproductive organs female rabbits material methods ovary virgin pregnant rabbits well oviduct uterus vagina virgin rabbits excised histologically processed cut slices organs used immunohistochemical studies tshr results presence trs tshr found primordial primary secondary tertiary graafian follicles virgin rabbits well corpora lutea corpora albicans wall hemorrhagic cysts pregnant rabbits oviductal regions fimbria infundibulum ampulla isthmus utero tubal junction uterus endometrium myometrium vagina abdominal pelvic perineal portions virgin rabbits showed anti trs anti tshr immunoreactivity additionally distal urethra paravaginal ganglia levator ani iliococcygeus muscles dorsal nerve body clitoris perigenital skin prostate trs tshr conclusions wide presence trs tshr female reproductive organs suggests varied effects thyroid hormones thyrotropin reproduction
background cerebral small vessel disease svd common cause cognitive decline old population mri used clarify mechanisms however surrogate markers mri early cognitive impairment svd remain uncertain date investigated cognitive impacts cerebral microbleeds cmbs diffusion tensor imaging dti brain volumetric measurements cohort post stroke non dementia svd patients methods fifty five non dementia svd patients consecutively recruited categorized two groups cognitive impairment nci vascular mild cognitive impairment vamci detailed neuropsychological assessment multimodal mri completed results two groups differed significantly scores cognitive domains except language patients hypertension depression vamci nci group multiple regression analysis cognition showed periventricular mean diffusivity deep cmbs numbers predictors attention executive function explained total variance periventricular independent predictor either memory visuo spatial function however small proportion variance could accounted respectively language found correlated mri parameters correlation found brain atrophic indices cognitive measures conclusion arteriosclerotic cmbs periventricular white matter disintegrity seem independent mri surrogated markers early stage cognitive impairment svd
advancement power electronics new materials novel bearing technologies active development high speed machines recent years simple rotor structure makes switched reluctance machines srm candidates high speed operation paper presents design low power rpm srm toroidally wound stator finite element analysis fea shows equivalence conventionally wound srms terms torque capability conventional asymmetric converter classic angular control toroidal winding srm tsrm able produce mechanical power efficiency fea stage considering enhanced cooling capability winding directly exposed air toroidal winding good option high speed srm
background objectives previous literature using small sample sizes limited geographic areas report overweight obesity physical inactivity occur higher rates among children autism spectrum disorder asd compared typically developing peers purpose study examine obesity overweight physical activity sedentary behavior among children youth without asd using nationally representative data controlling secondary conditions including intellectual learning disabilities adhd developmental delay mental physical medical conditions well medication use methods data collected national survey children health cross sectional survey weighted children aged asd weighted logistic regression used estimate odds ratios adjusting demographics possible secondary conditions results diagnosis asd associated higher odds obesity however additional adjustment possible secondary conditions asd diagnosis longer associated obesity moderate asd reported lower odds sedentary behavior association failed achieve significance adjustment secondary conditions medication use significant associations asd overweight physical activity found conclusions findings suggest asd diagnosis significantly associated obesity status adjustment possible secondary conditions medication use decision makers clinicians researchers developing interventions children asds consider secondary conditions may impact obesity related activities
hyperprolactinemia common severe antipsychotic induced adverse drug reaction meta analysis randomized controlled trials systematically examined efficacy safety adjunctive metformin antipsychotic related hyperprolactinemia schizophrenia patients two independent investigators searched extracted synthesized data weighted mean differences risk ratios confidence intervals calculated using random effect model four randomized controlled trials comparing adjunctive metformin control groups lasting weeks treatment included meta analysis metformin group significantly lower serum prolactin level endpoint four randomized controlled trials weighted mean difference confidence interval moderate quality based grading recommendations assessment development evaluation system patients menstrual disturbances rate menstruation resumption metformin group control group adverse drug reactions cause discontinuation three randomized controlled trials risk ratio confidence interval similar two groups adjunctive metformin appears effective safe reducing antipsychotic induced hyperprolactinemia prolactin related symptoms schizophrenia patients higher quality randomized controlled trials large sample size warranted confirm findings
paper show plants respond downstream ambient water quality controlling permitted levels pollution find past water quality declines one percent plants reduce current pollution percent magnitude coefficient comparable coefficient permitted discharge levels regulatory stringency results consistent two mechanisms first decline water quality may lead stringent permits would raise cost abatement plant significantly second plant likely subject increased public pressure response poor water quality indeed expected impact water quality becomes stronger locations higher median household income higher percent carpooling work lower percent manufacturing employment surprisingly lower median age residents lower percent bachelor degree higher percent families children elsevier inc rights reserved
typing classification escherichia coli coli according cell wall components like polysaccharides routinely done serotyping given presence known antigens process complex authors present proof concept planar microbead array multiplexed serotyping ten clinically relevant coli serotypes associated high risk diarrhea humans examined antisera assigned specific microbead populations differentiated size fluorescence color automatted image processing data analysis conducted microscopic interpretation platform homogenous antiserum coating microbeads demonstrated intra population ranges inter population typical detections limits range refmfi significantly elevated fluorescence signals revealed coli certain serogroup bound specifically microbeads matching antiserum perception method represents viable diagnostic tool automated multiplex serotyping coli enables simultaneous high throughput screening different antigens simple staining binding protocol
backgroundadolescence period increased risk development depression epidemiological clinical studies suggest phenomenology depression may differ childhood adolescence however participants studies may reflect depressed young people referred routine clinical services aim paper describe referrals depression routine public healthcare service children adolescents mental health difficulties methodthis paper describes consecutive series adolescents aged years referred depression routine public healthcare child adolescent mental health service south england young people caregivers completed structured diagnostic interview self report measures anxiety depression resultsfewer half young people referred depression met diagnostic criteria depressive disorder key symptoms reported depression low mood irritability cognitive disturbances sleep disturbances negative self perceptions suicidal ideation common considerably higher reported studies caregiver young person accounts adolescent symptoms depression anxiety uncorrelated caregivers also reported fewer symptoms depression child adolescents conclusionsthese data direct relevance design delivery public mental health services children adolescents however know representative sample clinical populations countries need collect routine data services assess needs group high risk adolescents
aggregation three different cyclodextrins cds hydroxypropyl cyclodextrin hydroxypropyl cyclodextrin sulfobutylether cyclodextrin sbe studied critical aggregation concentration cac three cds quite similar situated small difference cac values determined dls nmr dls measurements revealed cds solution three size populations wherein one single molecule size aggregates determined tem appears similar size aggregates second size distribution determined dls isodesmic self assembly models used studying aggregation process sbe results showed aggregation process cds cooperative one first step aggregation less favorable next steps determined thermodynamic parameters showed aggregation process three cds spontaneous exothermic driven increase entropy environment elsevier rights reserved
objective critically assess evidence specific standardised extract trifolium pratense isoflavones promensil dosage day treatment menopausal hot flushes data sources systematic literature searches performed medline scopus cinahl plus cochrane amed inforrmit citations obtained march reference lists checked corresponding authors contacted grey literature searched additional publications review methods studies selected according predefined inclusion exclusion criteria randomised clinical trials specific standardised extract trifolium pratense isoflavones promensil used mono component day measuring vasomotor symptoms included data extraction quality assessment performed independently one reviewer validated second disagreements settled discussion weighted mean differences confidence intervals calculated continuous data using fixed effects model results twenty potentially relevant papers identified five studies meeting inclusion criteria meta analysis demonstrated statistical clinically relevant reduction hot flush frequency active treatment group compared placebo weighted mean difference hot flushes per day due lack homogeneity priori defined sub group analyses performed demonstrating substantive difference cross parallel arm clinical trial designs conclusion evidence statistical clinically significant benefit using specific standardised extract red clover isoflavones promensil day treating hot flushes menopausal women across studies included meta analysis preparation safe short term duration studies months authors published elsevier gmbh
understanding hydraulic system one learning objectives manufacturing engineering studies generally knowledge hydraulic system components learned textbooks existence conventional tutorial props considered help understanding materials enough ability give clear illustration component system working paper aims look far custom made hydraulic system tutorial props transparent flow concept improve competence students understanding work hydraulic system tutorial props hydraulic system designed theme material handling using robotic arm dual acting cylinder actuator support movement arm components flowed fluid including valves hoses pumps actuators made transparent material flowed visible colored fluid whole system component equipped label containing name schematic symbol fluid flow direction tutorial props operated manually designed easily knocked based verification using questionnaire technology acceptance model tam students obtained value indicates tutorial props quite acceptable based implementation test comparing difference value pretest posttest students using textbooks learning method students using tutorial props learning method found significant differences indicate using tutorial props better learning method authors published elsevier
test whether adaptive program improves outcomes drug court adjusting schedule court hearings clinical case management sessions pursuant priori performance criteria consenting participants misdemeanor drug court randomly assigned adaptive program baseline matching condition attended court hearings based results criminal risk assessment outcome measures arrest rates months post entry drug court urine drug test results structured interview results months post entry although previously published analyses revealed significantly fewer positive drug tests participants adaptive condition first weeks drug court current analyses indicate effects converged ensuing year group differences new arrest rates urine drug test results self reported psychosocial problems small non statistically significant months post entry non significant trend suggests may small residual impact cramer new misdemeanor arrests months adaptive programming shows promise enhancing short term outcomes drug courts however additional efforts needed extend effects beyond first months enrollment
objective intimate partner violence ipv serious public health problem affecting every women lifetime latinas found experience ipv rates equal even higher rates general population consequences experiencing violence severe result increased risk developing physical mental health problems notably posttraumatic stress disorder ptsd although treatments ptsd ipv exposed women developed evaluated first study test efficacy program tailored specifically meet needs latinas experience ipv method study examines efficacy spanish language adaptation moms empowerment program week group treatment program ipv exposed women total low income mostly immigrant latinas included community trial women spanish speaking information violence exposure ptsd symptoms collected immediately implementation intervention results findings show women participated intervention significantly greater reduction ptsd symptoms women wait list comparison group specific reductions symptom domains also analyzed conclusions adaptation program designed reduce problems associated experiencing ipv addressed several mental health treatment needs latinas particularly need services spanish findings demonstrate possible tailor current treatment programs ipv ways effective culturally sensitive
psoriasis complex inflammatory disease occurs genetically susceptible individuals presents development erythematous scaly plaques skin interleukins ils pathway play pivotal role pathogenesis psoriasis thus become targets recent biologic drug development secukinumab human monoclonal iggk antibody developed target block actions secukinumab recently approved use first line systemic therapy patient moderate severe psoriasis studied first psoriasis diseases phase iii clinical trials demonstrated effectiveness secukinumab treatment moderate severe plaque psoriasis demonstrated superiority comparable biologics market including tumor necrosis factor inhibitor etanercept secukinumab also shown superiority ustekinumab relatively recent biologic introduced treatment psoriasis besides demonstrating better efficacy compared etanercept ustekinumab secukinumab also demonstrated greater impact quality life patients comparable safety profile secukinumab shows great promise tremendous impact treatment plaque psoriasis based ability produce similar better clinical outcomes biologic antipsoriasis medications
study develops general analytical model describing transient drawdown distribution induced pumping finite radius well radial two zone confined aquifer finite areal extent robin type condition inner outer boundaries model also applicable heat conduction problems composite hollow cylinder basis analogy heat flow groundwater flow time domain solution model derived methods laplace transform bromwich integral residue theorem new solution reduce solution constant head test cht constant rate test crt problem specifying appropriate coefficients robin inner boundary condition solution describing flow rate across wellbore due cht developed applying darcy law new solution addition steady state solutions cht crt also developed based approximation bessel functions small argument values many existing solutions transient flow homogeneous two zone finite aquifers dirichlet flow condition outer boundary shown special cases present solution furthermore sensitivity analysis also performed investigate behaviors wellbore flow due cht aquifer drawdown induced crt response change aquifer parameters elsevier rights reserved
gender role beliefs african american women differ women ethnic racial groups culturally valid measure gender role beliefs needed three studies conducted develop preliminary measure study focus groups conducted community college sample african american women transcripts reviewed resulted initial pool items items reviewed expert panel items retained study exploratory factor analysis computed data african american female college students items included along measures assess convergent discriminant validity nine items retained nine items comprised two subscales labeled agency caretaking scales demonstrated good internal consistency convergent discriminant validity study confirmatory factor analysis computed different sample african american female college students confirmatory factor analysis showed acceptable fit two factor structure agency caretaking
aim determine whether oral administration bifido bacterium infantis cgmcc infantis cgmcc inhibits allergen induced airway inflammation food allergies mouse model methods ovalbumin ova induced allergic asthma beta lactoglobulin induced food allergy mouse models used study following oral administration infantis cgmcc allergen sensitization histopathologic changes lung intestine evaluated hematoxylin eosin staining allergic asthma mouse model evaluated proportion lung infiltrating inflammatory cells ova specific ige igg levels serum cytokine levels bronchoalveolar lavage fluid balf also assessed food allergy mouse model levels total ige cytokines serum measured results oral administration infantis cgmcc allergen sensitization suppressed allergic inflammation lung intestinal tissues proportion infiltrating inflammatory cells significantly decreased balf allergic asthma mice moreover infantis cgmcc decreased serum levels total ige food allergy mice reductions ige igg also observed ova induced allergic asthma mice expression interleukin serum balf suppressed following administration infantis cgmcc effect serum levels observed conclusion infantis cgmcc inhibits secretion allergen induced ige attenuates allergic inflammation
paper extends capabilities smith chart representing positive negative differential phase group delay associated loaded resonator quality factor displayed simultaneously scattering parameters mathematical concepts inspired elementary differential geometry topology used implement projections shown condition circuit exploit negative differential phase group delay parameter winding number relative origin finally exemplar network responses exhibit positive negative differential phase group delay loaded resonator quality factor shown smith chart convenience able simultaneously display wider range parameters one visualization platform smith chart may help speed design analysis microwave circuits user
modern service providers use virtualization order feasibly scale applications approaches exploit virtual machines master quality service requirements primarily redundancy reliability security accordingly services provided hosted data centers fulfill customers needs standards entry burden small enterprises requiring establish distributed service delivery cloud therefore developed energy efficient solution hypriot cluster lab hcl adapts docker technologies order run arm powered single board computers herein demonstrate hcl works redundancy replication several hosts different locations via wide area networks accordingly use mesh network based virtual private lans enable encrypted communication internet distributed hosts result presents fault tolerant reliable secure extension connect several independent hosts hcl achieve qos requirements
paper describe methods analysis concerning efficiency electrical power consumption efficiency electrical power transfer electrical generator electrical consumers presence unbalanced non linear consumers analysis gets complicated situations described analysis points upon importance electrical current flow computation precise flow sequence negative component electrical current harmonic components
chronic health conditions elderly lead limitations physical activity disability anxiety increased need medical care assisted living conditions physical performance tests used screen pending loss mobility serve endpoints monitor effectiveness intervention measures since limited mobility associated physical mental health person evaluation preclinical aging studies mice provide translational approach testing new intervention strategies assessed physiological parameters month old cbl cbf male mice using rotating rod free running wheel photo beam activity field designed determine changes coordinated walking ability self motivated running distance anxiety response novel environment respectively older mice showed decreased coordinated walking times decreased running distances predictive physical performance ability motivation elderly changes lateral vertical movements observed novel cage environment suggesting different levels anxiety genetic background two mouse strains influenced test results age dependent manner imperative recognize diverse genetic backgrounds mice may yield different data preclinical studies would need interpreted individually translational applications elsevier inc rights reserved
digital forensics become flourishing research area electrical network frequency enf plays important role assessing authenticity digital recording audio enf criterion tool extracting embedded power line frequency recording cross correlation reference pmu data extracted enf signal done order determine authenticity audio signal paper empirical wavelet transform ewt used extracting enf audio signal ewt decomposes signal modes hilbert transform used compute instantaneous frequency amplitude extracted mode corresponding enf ewt method able capture weak harmonics signal problem resolved fixing frequency domain boundaries mode authors published elsevier ltd
introduction angioedema characterized subcutaneous submucosal swelling usually localized lips eyelids tongue oral cavity larynx pharynx various types angioedema caused different pathophysiologic mechanisms similar clinical picture require different diagnostic therapeutic procedures immediate threat life result rapidly developed edema pharynx larynx airway obstruction requires endotracheal intubation emergency tracheotomy standard therapy includes epinephrine second generation antihistamines steroids effective treatment types angioedema objective basis clinical presentation course angioedema retrospective study aimed contributing better understanding etiopathogenesis disease helping determine effective available treatment modalities methods retrospective study included patients treated diagnosis angioedema upper aerodigestive tract department otorhinolaryngology clinical center banja luka results total subjects included study average age years male female patients largest number patients type angioedema almost half patients patients treatment angiotensin converting enzyme inhibitor acei statistically significant difference total number patients conclusion better understanding pathophysiologic mechanisms adoption diagnostic protocols contributes effective treatment angioedema
internet things lot become novel paradigm includes globally identifiable physical objects integrated internet work presents attack detection model using artificial neuro fuzzy interface system anfis lot networks based input output profile anfis adapts rules membership parameters using hybrid back propagation learning algorithm paper sugeno type anfis considered anfis model take dynamic information traffic flow energy level packet size packet rate source destination address source destination ports etc input profiles generate current network security state output profile performance anfis attack detection model compared fuzzy logic neural networks pattern recognition based attack detection models performance evaluation shows proposed model reliable approaches based confusion matrix mean square error accuracy measurement
aimdecreasing behavioral independence levels increasing frequencies behavioral disturbances problematic aspects people dementia however relative effects dementia factors unknown investigated variability behavioral independence disturbance profiles patients dementia methodsthis cross sectional correlation study inpatients dementia convalescent wards hospital enrolled assessed cognitive impairments mini mental state examination evaluated behavioral independence levels functional independence measure assessed frequency behavioral disturbances dementia behavior disturbance scale resultscoefficient determination mini mental state examination functional independence measure scores mini mental state examination dementia behavior disturbance scale scores functional independence measure dementia behavior disturbance scale scores easily accomplished behavioral independence eating hardest transfer tub shower behavioral disturbance highest frequency urinary incontinence lowest emptying drawers closets conclusionsmoderate correlations found severity dementia behavioral independence levels frequencies behavioral disturbances easier harder accomplish behaviors higher lower frequencies behavioral disturbances geriatr gerontol int
compared chronological age criminologists paid less attention biological sense age typically expressed pubertal development studies examined pubertal timing effects delinquency almost exclusively conducted western countries using mostly white samples knowledge study ever examined issue asian context current study first attempt bridge research gap examining association among menarcheal timing sex composition schools delinquency representative sample ninth grade girls south korea results show significant association early menarche delinquency exists mixed sex schools girls schools addition significant linkage early menarche delinquency mixed sex schools mediated delinquent peer associations
contribution addresses development linear quadratic regulator order control concentration profiles along catalytic distillation column modelled set coupled hyperbolic partial differential algebraic equations pdaes proposed method based infinite dimensional state space representation pdae system generated transport operator presence algebraic equations makes velocity matrix transport operator spatially varying non diagonal necessarily negative domain optimal control problem treated using operator riccati equation ore approach existence uniqueness non negative solution ore shown ore converted matrix riccati differential equation allows use numerical scheme solve control problem result extended design optimal proportional plus integral controller reject effect load losses performance designed control policy assessed numerical study elsevier ltd rights reserved
loneliness subjective experience often examined using self reports yet researchers started use reports examine loneliness previous research suggests discrepancies self views might important implications adolescents mental health current study examines discrepancies multi informant reports adolescents loneliness relation prosocial behavior aggression adolescents parent related loneliness sample consisted mother adolescent dyads father adolescent dyads male age years results indicated informants used different reference points assess adolescents peer related loneliness otherwise comparable moreover informant discrepancies associated greater adolescents reported parent related loneliness current study provide evidence discrepancies related prosocial aggressive behavior current study adds notion reports loneliness show substantial convergence self reports addition study indicates discrepancy self reports loneliness holds valuable information adolescent socio emotional adjustment
use absolute pretreatment apparent diffusion coefficients adc derived diffusion weighted imaging dwi predict response repetitive ctace unresectable liver metastases colorectal carcinoma crlm months start treatment fifty five metastases patients examined dwi prior treatment month initial ctace treatment performed week intervals response evaluated months start therapy metastases showing decrease axial diameter classified responding lesions one month initial ctace seven lesions showed early response significant difference absolute pretreatment adc values responding non responding lesions three months initial ctace metastases showed response significant difference absolute pretreatment adc values lesions showing response median response median pretreatment adc showed fair diagnostic value predict response auc lesions showing response months also revealed significant increase adc measurements treatment one month initial ctace applying increase adc response months initial ctace could predicted sensitivity specificity respectively auc furthermore strong significant correlation percentage change size third ctace percentage change adc patients crlm adc measurements potential biomarkers assessing response ctace
human activity recognition widely studied since last decade ambient intelligence scenarios remarkable progresses made domain especially research lines ambient assisted living gesture recognition behaviour detection classification etc works literature focus activity classification recognition prediction future events anomaly detection prevention however hard find approaches recognize activity also provide evaluation performance according optimality criterion problem special interest applications sports performance evaluation physical therapy etc work address problem evaluation human activities monitored environments using depth sensors particular propose system able provide automatic evaluation correctness performance activities involving motion specifically diagnosis exercises physical therapy
aim study investigate behavioral cues displayed trait judgments formed anxious interviewees anxious interviewees receive lower interview performance ratings behavioral expression interview anxiety model created conceptual framework explore relations videotaped transcribed mock job interviews obtained ratings interview anxiety interview performance trained raters assess several verbal nonverbal cues trait judgments results indicated behavioral cues several traits related interviewee interviewer ratings interview anxiety two factors emerged factor analysis trait judgments assertiveness interpersonal warmth mediation analyses performed indicated assertiveness interpersonal warmth mediated relation interview anxiety interview performance speech rate words spoken per minute assertiveness found mediate relation interviewee interviewer ratings interview anxiety overall results indicated interviewees focus less nervous tics broader impressions convey findings indicate anxious interviewees may want focus assertive interpersonally warm appear interviewers knowledge first study use validated interview anxiety measure examine behavioral cues traits exhibited anxious interviewees offer new insight anxious interviewees receive lower interview performance ratings
introduction chronic kidney disease ckd adults common condition major public health issue worldwide related high risk end stage renal disease esrd cardiovascular disease death given increasing incidence ckd availability effective therapeutic measures vital importance perform early detection risk factors order delay prevent progression esrd optimal cost effective strategy seems investigation aimed patients one risk factors ckd order detect early indicators ckd associated risk factors conducted study adult population methods cross sectional study evaluated bmi blood glucose serum creatinine albumin creatinine ratio urine sample people years participants classified stages ckd according presence albuminuria estimated glomerular filtration rate mdrd ckd epi statistical analysis stata used fisher exact test ttest cox regression explore association variables effect measure considered significant years hypertension obesity carbohydrate metabolism disorders chmd diabetes dbt smoking albuminuria ckd found participants male albuminuria gfr obesity hypertension diabetes educational level hypertensive patients chmd albuminuria know condition conclusion population male years hypertension obesity diabetes increases risk developing ckd identified high percentage individuals erc implementation campaigns early detection treatment would reduce incidence progression ckd found frequency ckd albuminuria similar others international reports contributing understanding disease prevalence argentina
background atopic allergy common among schoolchildren finland compared russian karelia adjacent regions show one contrasting socio economical differences world objective explored changes allergy school age young adulthood two areas skin nasal microbiota also compared methods randomly selected children finnish russian karelia examined children years age finnish karelia russian karelia analysed self reported allergy symptoms sensitization common allergens serum sige values skin volar forearm nasal mucosa microbiota collected aged years identified dna samples compared multivariate methods results asthma hay fever atopic eczema self reported rhinitis well atopic sensitization threefold fold common finland compared russian karelia hay fever peanut sensitization almost non existent russia patterns remained throughout year follow skin microbiota well bacterial fungal communities nasal mucosa contrastingly different populations best characterized diversity abundance genus acinetobacter abundant diverse russia overall diversity significantly higher among russian subjects skin pnasal bacteria pnasal fungi allergic diseases associated microbial diversity finnish subjects conclusions clinical relevance differences allergic phenotype developed early life remain populations parallel difference composition skin nasal microbiota suggests potential underlying mechanism results also suggest high abundance diversity acinetobacter might contribute low allergy prevalence russia implications early life exposure acinetobacter investigated
turbocompounding process recovering proportion engine fuel energy would otherwise lost exhaust process adding output power first seen carried coupling exhaust gas turbine crankshaft reciprocating engine since recognised coupling power turbine electrical generator instead crankshaft potential reduce fuel consumption added flexibility able decide recovered energy used electricity generated used automotive applications assist crankshaft using flywheel motor generator power ancillaries would otherwise run crankshaft case stationary power plants assist electrical power output decoupling power turbine crankshaft coupling generator allows power electronics control turbine speed independently order optimise specific fuel consumption different engine operating conditions method energy recapture termed turbogenerating paper gives brief history turbocompounding thermodynamic merits moves give account validation turbogenerated engine model model used investigate needs done engine turbogenerator installed engine modelled used stationary power generation fuelled induced biogas small portion palm oil injected cylinder initiate combustion compression ignition investigations optimum settings found result improvement overall efficiency savings relate engine without turbogenerator installed operating fixed fuelling
oxidative dna damage proposed one causes schizophrenia post mortem data indicate dysregulation apoptosis patients evaluate apoptosis vivo quantified concentration plasma cell free dna cfdna index determined using fluorescence levels oxodg cfdna immunoassay lymphocytes oxodg index flow cytometry male patients acute psychotic disorders paranoid total schizophreniform alcohol induced psychotic disorder healthy males cfdna change compared controls patients elevated levels oxodg found cfdna lymphocytes main sources cfdna dying cells oxidized dna thus cfdna oxodg ratio shows level apoptosis damaged cells two subgroups identified among patients median values cfdna oxodg index related patients psychotic disorders healthy controls cfdna oxodg values within range values thus apoptosis impaired approximately one third patients leads increase number cells damaged dna patient body tissues may contributing cause acute psychotic disorder elsevier ltd rights reserved
evidence health disparities sexual minority heterosexual populations although focus lesbian gay bisexual transgender health research human immunodeficiency virus acquired immunodeficiency syndrome sexually transmitted infection among men sex men health disparities among sexual minority women using minority stress framework disparities may part caused individual prejudice social stigma discrimination ensure equitable health urgent need targeted culturally sensitive health promotion cultural sensitivity training health care providers intervention focused research
investigated femtosecond soliton propagation inhomogeneous fiber described modified inhomogeneous hirota equation variable coefficient mih aid akns method corresponding lax pair constructed virtue darboux transformation method symbolic computation analytic one two soliton solutions explicitly obtained using obtained solutions graphically discuss features femtosecond solitons modified inhomogeneous hirota system changing profile variable coefficients analyze various form group velocity dispersion third order dispersion nonlinearity parameter periodic amplification system exponentially distributed system parabolic solitons periodic exponentially modulated system observable future experiments results potentially useful future experiments soliton control long distance optical communication finally soliton solutions mih equation double wronskian form constructed verified using wronskian technique substitute bilinear equations
thermal stratification unburned charge prior ignition plays significant role governing heat release rates homogeneous charge compression ignition hcci engine deep understanding conditions affecting thermal stratification necessary actively managing hcci burn rates expanding operating range end single cylinder gasoline fueled hcci engine used characterize relationship key operating conditions intake temperature residual gas fraction air fuel ratio swirl thermal stratification recently developed thermal stratification analysis applied calculate unburned temperature distribution prior ignition heat release comparison induction exhaust gas air fuel ratio air dilution air fuel ratio shows presence internal residuals increases burn duration broadens temperature distribution much results intake temperature combustion phasing sweep air fuel ratio show heat release rates increase advancing phasing however temperature distributions broaden comparing advanced retarded cases add insight removing effect combustion phasing equivalence ratio sweep compared intake temperature sweep shown significant part broadening distributions attributed exclusively increased intake temperature elevates maximum tdc temperature leaving wall region unaffected however combustion phasing plays role well earlier combustion phasing responsible additional broadening temperature distribution addition swirl elongates burn duration broadening temperature distribution effect slightly larger earlier combustion phasings however swirl significantly increases heat transfer losses reduces efficiencies much percentage points finally load sweep compensation ensure constant combustion phasing indicates higher loads result increased heat release rates narrower temperature distributions much elsevier ltd rights reserved
heart databases data model referred schema relational databases store information tables schema defines tables provides map relationships show different table data types relate one another xenbase tasked represent genomic molecular biological data diploid tetraploid xenopus species database model built decade ago little information nature laevis tetraploidization chado based data model proposed could deal various forms data species laevis genome sequenced annotated became clear data schema like evolutionary schema resulted laevis genome karger basel
study presents hierarchical distributed structure based holonic concept reactive power control smart grids holons main parts proposed framework able negotiate together change boundaries alter role members abilities improve flexibility performance novel structure order adapt different situations proposed methodology successfully scrutinised different case studies based transmission test system connected seven distribution networks new method compared two structures using set evaluation indices simulation results revealed improving computational efficiency minimising active power losses voltage deviations optimal utilisation reactive power sources less data traffic loads increasing fault tolerance key features proposed approach
paper presents unsupervised approach feature binary coding efficient semantic image retrieval although majority existing methods aim preserve neighborhood structures feature space semantically similar images always neighbors rather distributed non linear low dimensional manifolds moreover images rarely alone internet often surrounded text data tags attributes captions tend carry rich semantic information images basis observations approach presented paper aims learning binary codes semantic image retrieval using multimodal information sources preserving essential low dimensional structures data distributions hamming space specifically finding low dimensional structures data using unsupervised sparse coding technique approach learns set linear projections binary coding solving optimization problem designed jointly preserve extracted data structures multimodal data correlations images texts hamming space much possible show joint optimization problem readily transformed generalized eigenproblem efficiently solved extensive experiments demonstrate method yields significant performance gains several existing methods
different aspects related rainwater demand supplies non potable uses sao paulo international airport guarulhos brazil analyzed investigated different demand stratum defined intended uses subsequently supply reservoir volume evaluated daily balance one year evaluated distinct scenarios considering different arbitrated volumes demands results indicated rainwater could supply airport cold water central air conditioning system demand considering maximum daily demand identified dia higher water cost scenario reservoir volumes presented efficiencies close payback years lower water cost scenario volumes showed payback years also considering maximum daily demand
society healthcare epidemiology america centers disease control prevention president council advisors science technology recognize need combat antimicrobial resistance promotion antimicrobial stewardship programs health care facilities virginia surveyed using item survey focused facility characteristics antimicrobial stewardship strategies antimicrobial stewardship activities highly variable many missing key personnel resources association professionals infection control epidemiology inc published elsevier inc rights reserved
analyze alteration lipid profile inflammatory markers serum patients gouty arthritis levels serum lipid profile reactive protein crp erythrocyte sedimentation rates esrs measured serum gout patients patients rheumatoid arthritis patients ankylosing spondylitis spondyloarthropathy spa patients osteoarthritis serum levels apoprotein apo significantly decreased patients gout compared spa patients serum levels crp significantly increased gouty patients compared spa patients furthermore serum levels esr significantly increased patients gout compared patients correlation analysis indicated levels apo negatively correlated serum esr crp respectively patients taken together study gives better understanding relationships serum lipid profile inflammatory markers gout patients
primary goals icoliaborate materials science engineering mse project improve student learning outcomes engagement completion rates introductory materials engineering courses extensive research project multidimensional includes several interrelated components founded upon best practices stem education research several individual elements within project operate simultaneously sequentially unite form novel teaching learning system first element project transformation structure basic mse course primarily deductive practice information communication technology ict enabled student centered inductive teaching learning environment collaborative learning active inquiry learning concept learning peer learning problem case based learning low stakes quizzing mini lectures time reading collaborative research writing constructive alignment important components multidimensional approach also completed part research program detailed explorations understand students pre course knowledge misperceptions investigation student preparation preparation influenced pre course concept knowledge overall course outcomes analysis felder index learning styles ils assessment student course section detailed analysis pre course knowledge misperceptions showed surprising lack pre conceptual knowledge revealed several important student misperceptions paper focuses components icoliaborate project researched analyzed developed fall winter timeframe first summary pre course assessment findings given paper second overview suite mse ipod applications newly developed web applications icoliaborate presented finally overview supporting web site project currently development described paper concludes description remaining objectives icoliaborate project future research directions
previous research shown anorexia nervosa bulimia nervosa expensive illnesses treat reduce economic burden adequate interventions need established objective conduct cost offset analyses evidence based treatment eating disorders using outcome data psychotherapy trial involving cognitive behavioral therapy cbt focal psychodynamic therapy fpt trial involving cbt assuming currently running ideal healthcare system using month prevalence based approach varying willingness participate treatment investigated whether potential financial benefits related treatment outweigh therapy costs population level elaborated formula allows calculating cost benefit relationships whereby calculation parameters based estimates data health institutions within german healthcare system additional intangible benefits calculated aid quality adjusted life years annual costs untreated eating disorder billion eur million eur independent willingness participate treatment cost benefit relationships treatment remained constant cbt fpt cbt consistency implies eur invested treatment eur could saved year findings suggest implementation evidence based psychotherapy treatments may achieve substantial cost savings population level
anomaly detection large area using hyperspectral imaging important application real time remote sensing anomaly detectors based subspace models suitable anomaly usually assume main background subspace dimensions known detectors detect anomaly range values dimension subspace objective paper develop anomaly detector extends range values assuming main background subspace unknown user specified dimension imposing covariance error diagonal matrix pixel image modeled sum linear combination unknown main background subspace unknown error unknown quantities degrees freedom find better way fit data model diagonal matrix covariance error error components become uncorrelated coefficients linear combination unknown solved using maximum likelihood estimation experimental results using real hyperspectral images show anomaly detector detect anomaly significantly larger range values dimension subspace conventional anomaly detectors
storage class memory scm potential revolutionize memory landscape non volatile byte addressable properties however little published work exploring usage modern virtualized cloud infrastructure propose scm vwrite novel architecture designed around scm ease performance interference virtualized storage subsystem case study typical virtualized cloud system first describe current writeback manners suitable virtualized environment design implement scm vwrite improve problem also use typical benchmarks realistic workloads evaluate performance compared traditional method conventional architecture experimental result shows scm vwrite coordinate writeback flows effectively among multiple located guest operating systems achieving better disk performance without loss reliability
general consensus literature individuals autism spectrum disorder difficulty cognitive empathy much less known emotional empathy processing individuals research employed subjective self report measures often misinterpreted reported reported objective measures psychophysiological recordings arousal offer objective response furthermore combining physiological responses self report ratings allows explore relationship two responses emotionally charged stimuli total individuals autism spectrum disorder compared matched controls physiological arousal psychological self report responses emotionally distressing video scenes responses also compared self report cognitive emotional trait empathy results indicate individuals autism spectrum disorder appear respond similarly controls physiologically interpretation response dampened emotionally furthermore dampening self report emotional response associated general reduction trait empathy
square root domain srd cmos analog realization single cell architecture complex temporal derivative cellular neural networks tdcnns introduced paper tdcnn initiates time derivative diffusion cnn cells non separable spatiotemporal filtering applications input cnn image changes time evaluation performance complex srd tdcnn cell done using cadence orcad software tsmc cmos process model parameters provided simulated results confirm validity theory
aim paper describe new energy dependency score methodology consequent application cars sold twelve regions europe eleven specific countries worldwide australia brazil china india japan norway portugal russia saudi arabia south africa usa methodology developed potential tool inform consumers choice impact country economy methodology based primary energy assessments origins energy pathway associated gasoline diesel natural gas used production electricity balanced country electricity mix powered vehicle energy dependency index attributed best case endogenous production worst case endogenous production scenarios consequently weighted vehicle fuel consumption enabled obtaining energy dependency index index could assigned environmental social index provide sustainability index therefore complement road vehicle environmental rating system providing combined index rating internal combustion engine vehicles hybrid vehicles oil products energy source rate lowest almost locations exception regions energy independent norway saudi arabia russia electric vehicles rank higher comparing technologies analyzed locations study plug hybrid electric vehicle shows generally rank intermediate place except japan scores lower technologies
birth foster adoptive parents raising child foetal alcohol spectrum disorder know children best well positioned inform professionals help alcohol affected children telephone interviews parents conducted explore strengths caregivers raising child foetal alcohol spectrum disorder responses analyzed using concept mapping methodology four themes emerged unique responses change parenting strategy different children use non verbal sensory physical strategies stay patient understanding locate maintain external supports results compared contrasted existing literature although many responses consistent literature strengths previously unreported caregivers literature included cultural practices communication generalizability skills soothing music use service dog
rehabilitation patients parkinson disease based cognitive strategies exploit attention parkinsonians exhibit impairments divided attention interference control nevertheless effectiveness specific rehabilitation treatments based attention suggests attentional functions preserved data attention conflicting clear whether rehabilitative treatments entail attentional strategies affect attention reaction times rts represent instrument explore attention investigate whether changes attentional performances parallel rehabilitation induced gains rts parkinsonian patients state without cognitive deficits compared population healthy controls studied attentional networks subtend use cognitive strategies motor rehabilitation alertness focused sustained attention component executive system used visual auditory rts evaluate alertness multiple choices rts rts explore focused sustained attention parkinsonian patients underwent tasks week multidisciplinary intensive goal based rehabilitation treatment mirt unified parkinson disease rating scale updrs iii timed test tug assessed enrollment end mirt evaluate motor functional effectiveness treatment find differences rts parkinsonian patients controls found improvements motor functional outcome measures mirt paralleled reduction rts changes found visual auditory rts correlation analysis revealed association changes rts improvements updrs iii tug findings indicate alertness well focused sustained attention preserved state explains parkinsonians benefit goal based rehabilitation entails use attention reduction rts suggests positive effect mirt executive component attention indicates type rehabilitation provides benefits exploiting executive functions ensues different training approaches aimed bypassing dysfunctional basal ganglia circuit allowing voluntary execution defective movements data suggest effectiveness motor rehabilitation tailored lies cognitive engagement
impact thyroid dysfunction subclinical ranges metabolic syndrome mets well known aim present study evaluate association thyroid dysfunction mets components cross sectional population based tehran thyroid study randomly selected participants aged years subjects thyroid nodules cancer severe systemic disease pregnant using thyroid medication excluded leaving subjects investigated body weight waist circumference blood pressure measured fasting blood glucose concentrations lipids lipoproteins free tsh assayed mean age participants overt hypothyroidism subclinical hypothyroidism overt hyperthyroidism subclinical hyperthyroidism mets clinically hypothyroid subjects highest prevalence mets abdominal obesity hypertriglyceridemia compared groups overt subclinical hyperthyroidism significantly higher odds hyperglycemia men women full adjustment age smoking bmi overt hypothyroidism subclinical hypothyroidism especially elderly could associated mets hyperthyroidism may induce hyperglycemia
novel motor design methodology optimization proposed applied srm greatly reduces finite element analysis use multi physics study realized order couple thermal magnetic electric motor analysis information obtained study allows creating different behaviors maps order evaluate motor operating area joule iron losses thermal network obtains temperature map current angular speed electric model uses parameters obtained reluctances network phase resistance variation obtained thermal lumped parameter finally optimal motor obtained validated fea sum motor design obtained using multi physics analysis taking account different operating points range operation optimization addition reducing fea computation time achieved methodology proposed
recent changes law new zealand led marked increase experts called give evidence cases alleged child sexual abuse outline common misconceptions held expert witnesses cases review research patterns abuse disclosure retraction symptoms abuse external influences children reports experts ability distinguish true false reports also consider experts say memory relevance cases conclude many long held notions child sexual abuse children testimony make way courtrooms supported empirical research raising questions isand notqualified act expert witness
introduction use bioadhesive hydrogels skin care presents important advantages long residence times application site reduced product administration frequency object aim present work develop bioadhesive hydrogels skin application using caffeine model active ingredient methods eight hydrogels formulated using binary combinations primary polymer carbomer homopolymer type carbopol kappa carrageenan potassium salt gelcarin secondary polymer carbomer copolymer type pemulen xanthan gum guar gum hydrogels characterized means ofphysico chemical dynamic rheological measurements spreadability adhesion measurements sensory methods projective mapping combination check apply cata question caffeine hydrogels formulated using two promising formulations regarding adhesion properties sensory characteristics vitro active ingredient release studies carried results hydrogel formulations showed prevalently elastic rheological behaviour complex viscosity carbomer homopolymer type hydrogels higher kappa carrageenan hydrogels besides complex viscosity values dependent secondary polymer present formulation significant differences among hydrogels found detachment force work adhesion spreading diameter results association projective mapping cata allowed determine similarities dissimilarities among samples cluster analysis associated samples two groups two hydrogels selected study release caffeine hydrogels presented similar release profiles well described higuchi model caffeine release exclusively controlled diffusive process conclusion physico chemical sensory techniques enabled identification bioadhesive hydrogel formulations positive characteristics cosmetic applications formulations combined carbomer homopolymer type xanthan gum carbomer copolymer type promising bioadhesive skin products caffeine release profiles selected formulations statistically different hydrogels gradually released active ingredient reaching approximately within first profiles well described higuchi model context could concluded selected hydrogels suitable bioadhesive hydrogel formulations cosmetic application skin
purpose review provision adequate nutrients gut essential survival essential behaviors linked proper ingestion digestion food recently new neural connection reported sensory cells gut epithelium nervous system mediates signals gut brain recent findings review describes gut senses environment relays signals brain brain influences gut summary gut brain connection provides pathway body handles food
background mobile health mhealth huge potential deliver preventative health services however paucity literature theoretical constructs technical practical regulatory considerations enable delivery services objectives objective study outline key considerations development text message based mhealth program thus providing broad recommendations guidance future researchers designing similar programs methods describe key considerations designing intervention respect functionality technical infrastructure data management software components regulatory requirements operationalization also illustrate potential issues decision points utilizing experience developing text message short message service sms management systems support large randomized controlled trials text messages improve medication adherence secondary prevention textmeds tobacco exercise diet messages text results steps identified development process background research development text message bank based scientific evidence disease specific guidelines pilot testing target audience incorporating feedback software hardware customization enable delivery complex personalized programs using prespecified algorithms legal regulatory considerations additional considerations developing text message management systems include balancing use customized versus preexisting software systems level automation versus need human inputs monitoring ensuring data security interface flexibility ability upscaling conclusions merging expertise clinical behavioral sciences health research data management systems software engineering mobile phone regulatory requirements essential develop platform deliver manage support programs hundreds participants simultaneously text textmeds trials research provides broad principles may assist researchers developing mhealth programs
large scale airports incheon international airport large scale terminals annex buildings numerous open spaces integrated space management system required manage buildings spaces efficiently thus incheon international airport corporation developed three dimensional computer aided design based integrated space management system major system development goal provide intuitive three dimensional based visual information thereby realizing integrated space asset management system require expert knowledge specific field architecture article discusses construction system problems resolved achieve goal
purpose aim study define types musculoskeletal injuries present senior international rowers according literature study performed group methods injury data obtained total rowers female male completed month retrospective questionnaire injury incidence participating senior world rowing championships munich germany results mean injury rate per one year injuries per rower injuries per training sessions per rower vast majority self reported injuries chronic injuries acute chronic ratio majority reported injuries result loss time training competition acute injuries sustained rowing specific training injuries sustained gym cross training common site injury low back followed knee chest thoracic spine senior open weight rowers sustained chronic injuries achieved significantly better final ranking senior world rowing championships compared group rowers sustain injury conclusion senior international rowers participating world rowing championships sustained predominantly chronic overuse injuries rowing season studied mainly low severity injuries low back frequently injured site study may help prevention early diagnosis eventual injuries top level rowers
presented project based learning pbl laboratory approach upper division environmental chemistry quantitative analysis course work combined laboratory class environmental chemistry students developed method based published epa methods extraction dichlorodiphenyltrichloroethane ddt environmental degradation products dichlorodiphenyldichloroethane ddd dichlorodiphenyldichloroethylene dde soxhlet extraction quantitation using gas chromatography mass spectrometry derived procedures students spent remainder semester performing extractions analyses detect pesticide drift san joaquin valley california sierra nevada mountain range epa methods used allow multitude research level questions could answered within similar course specific question appropriate student interest regional environmental issues pedagogical approach provided numerous teaching moments regarding pitfalls research low level quantitation environmental samples well development opportunities student teamwork skills individual focused specific aspect project throughout semester
thermodynamic data needed kinds simulations materials processes thermodynamics determines set stable phases also provides chemical potentials compositions driving forces nucleation new phases phase transformations software simulate materials properties needs accurate consistent thermodynamic data predict metastable states occur phase transformations due long calculation times thermodynamic data frequently pre calculated lookup tables speed calculations creates additional uncertainties data must interpolated extrapolated conditions may differ assumed creating lookup table speed accuracy requires thermodynamic software fully parallelized opencalphad software first thermodynamic software supporting feature paper gives brief introduction computational thermodynamics introduces basic features software presents four different application examples demonstrate versatility elsevier rights reserved
overuse groundwater coastal areas due high population agricultural activity results seawater intrusion coastal aquifer paper presents control measures taken manage aquifer recharge mar also overcome problem seawater intrusion coastal aquifer along kalangi river nellore district andhra pradesh india connectivity pulicat saltwater lake estuary due overexploitation groundwater less rainfall past years adjacent seawater started intruding kalangi river sub surface deteriorating groundwater quality confluence river pulicat lake prevent situtation subsurface dams constructed traditional manner using local earth material three different places across kalangi river near sullurpet town water storage capacities calculated sub surface dams construction mcft engineering college mcft challamagudi mcft holy cross school sites holy cross school sub surface dam first full scale dam cum check dam constructed prevent salt water intrusion kalangi river sullurpet nellore district andhra pradesh kalangi river estuary portion mouth sea groyne reconstructed old groyne site introduction clay bed wooden sheet piles stream apart prevention sea water entry kalangi river sub surface seasons groyne top level raised prevent mixing high sea water tides fresh water ensuring additional storage fresh water upstream side reconstructed groyne serving purpose obstructing surface seawater entry kalangi river water quality improved river well wells construction sub surface dam per simpson ratio classification substantial improvement water quality shar infiltration well situated near holy cross school sub surface dam
thin cap fibroatheroma tcfa vulnerable plaque responsible majority coronary artery death virtual histology intravascular ultrasound ivus image clinically available method visualizing color coded tissue maps however technique considerable limitations providing medical relevant information identifying vulnerable plaque aim paper improve identification tcfa ivus image therefore paper proposes set algorithms segmentation feature extraction plaque type classification accurately identify tcfa hybrid model using fcm knn hfcm knn proposed accurately segment ivus image proposed technique capable eliminating outliers detecting clusters different densities ivus image next process extracting plaque features provide accurate definition unstable vulnerable plaque achieve contribution five algorithms proposed extract significant features ivus images machine learning approaches applied training vivo images obtained patients results proved dominance proposed method tcfa detection accuracy rate compared obtained cardiologist decision moreover validation ivus images corresponding optical coherence tomography oct images accuracy achieved elsevier rights reserved
widely believed warm supportive parenting fosters kinds prosocial behaviors offspring including civic engagement however accumulating international evidence suggests effects family support civic engagement may sometimes negative address apparent controversy identified several scenarios negative effects supportive parenting youth civic engagement tested using four waves data finnish educational transitions studies followed students female late adolescence young adulthood included maternal offspring reports parental support assessed civic engagement young adulthood control variables included socioeconomic status sociodemographic indicators church belonging personality traits earlier civic engagement higher maternal warmth support stronger identification parental family adolescence predicted offspring lower political activism years later perceived parental support young adulthood predicted lower volunteering years later significant effects general organizational involvement student hobby associations none priori scenarios identified literature appeared explain pattern results satisfactorily put forth cultural life stage explanations findings
paper model single photon amplification based cluster state quantum computation proposed rescaling probability amplitudes deteriorated qubit favor one photon component define amplifier gain unlike heralded quantum amplifiers probabilistic success whole process depend successful detection heralding signal instead whole procedure rely upon single qubit measurement simpler compared two qubit interaction gate heralded quantum amplifiers proposed model used qubit protector propagation losses long distance quantum communication networks
background transforming growth factor beta tgf beta gene variants extensively studied various human diseases example tgf beta polymorphisms associated fibrosis pneumoconiosis data remained controversial aim meta analysis assess association tgf beta polymorphisms pneumoconiosis methods comprehensive literature search conducted searching pubmed embase chinese biomedical database wei chinese database end april eleven publications studies included meta analysis covering total patients pneumoconiosis controls study quality assessed heterogeneity publication bias measured statistical analyses performed using stata version statacorp college station usa software results data showed significant associations tgf beta polymorphism risk pneumoconiosis development odds ratio confidence interval tgf beta polymorphism pneumoconiosis risk addition subgroup analysis ethnicity versus pneumoconiosis types indicated significant association silicosis among asian populations coal workers pneumoconiosis caucasian populations contrast significant association exhibited tgf beta polymorphism risk pneumoconiosis conclusion polymorphisms tgf beta associated increased risk pneumoconiosis
family structures diversify attitudes towards nontraditional families sex parent cross race families appear becoming favorable despite favorable attitudes propose explicitly implicitly people view nontraditional families less family like traditional heterosexual race families also propose people hold behavior nontraditional traditional families higher standards study participants explicitly rated nontraditional traditional family photos less family like less loving study using reaction time measure participants took longer correctly categorize nontraditional traditional families family category suggesting implicit level people greater difficulty recognizing nontraditional families family studies ambiguous positive negative behavior licensed harsh evaluations nontraditional familybut affect evaluations traditional familyrelative learning positive family behavior despite survey data suggest people views nontraditional families becoming favorable evidence indicates people nonetheless harbor prejudice certain family structures beyond documenting two biases nontraditional families work highlights need prejudice researchers examine meaningful levels social identity family units intermediate individuals broad social classes
nrg loops source level abstractions allow application dynamically manage power energy adjustments functionality performance accuracy adjustments come form truncated adapted perforated loops conditionally enabled runtime power energy constraints dictate nrg loops portable across different hardware platforms operating systems complementary existing system level efficiency techniques dvfs idle states using prototype library supported commodity hardware energy meters modifications compiler operating system paper demonstrates four nrg loop applications lines source code changes save power energy resulting better energy efficiency system level techniques
spinel type magnetic manganese ferrite mnfeo microspheres synthesized simple solvothermal method used novel adsorbent selective enrichment effective isolation phosphopeptides uniform mnfeo magnetic affinity microspheres mamss narrow particle size distribution displayed superparamagnetism saturation magnetization value emu comprehensively possible formation mechanism mnfeo microspheres ferric manganous sources dual precursors elucidated comparison feo nanoparticles mnooh nanosheets respectively either ferric manganous source single precursor suggested spherical sheet nanostructures could achieved via secondary recrystallization ostwald ripening mnfeo mamss probe exhibited excellent dispersibility aqueous solution rapid magnetic separation within well good reusability importantly mnfeo highly selective phosphopeptides strong coordination interaction metal ions phosphate groups phosphopeptdies high specificity demonstrated effectively enriching phosphopeptides digest mixture beta casein bovine serum albumin bsa high content non phosphopeptides embodied phosphopeptides enrichment non fat milk digests human serum consequently prepared mnfeo affinity materials expected possess great potential phosphoproteome research
wraparound team based care coordination strategy children youth complex behavioral health needs families despite widespread adoption review literature pertaining wraparound previously conducted address gap conducted comprehensive review ultimately identifying unique wraparound related publications peer reviewed outlets coded analyzed publications methods main foci measures findings eighty three publications non empirical focused defining wraparound advocating use largely based alignment system care philosophy among empirical studies controlled studies found finding positive mixed evidence wraparound effectiveness empirical studies examined implementation issues necessary system conditions measurement influence fidelity major gaps include rigorous tests wraparound change mechanisms workforce development models peer support use specific treatments conclude literature produced date provided useful information wraparound core components program level system level implementation supports applicability across systems populations well preliminary information effectiveness cost effectiveness wraparound research base would however benefit additional studies model intervention implementation components well rigorous effectiveness studies
myelofibrosis chronic progressive hematologic malignancy median overall survival approximately years allogeneic hematopoietic stem cell transplantation hsct sole treatment approach offers curative potential use reduced intensity conditioning regimens expanded application hsct patients age years recent retrospective prospective reports suggested worse hsct outcomes patients receiving unrelated donor graft compared receiving related donor graft identify patient hsct specific variables influencing outcomes conducted retrospective analysis patients chronic advanced phase underwent hsct institution cohort median follow months progression free survival pfs months months multivariable analysis sole clinical variable negatively influenced outcome use unrelated donor median pfs months versus yet reached patients receiving related donor graft years confidence interval nonrelapse mortality nrm unrelated donor graft group compared related donor graft group difference rates grade iii acute graft versus host disease unrelated related donor groups versus despite aggressive disease state year pfs patients myeloproliferative neoplasm blast phase undergoing hsct graft failure rate higher patients receiving mismatched donor graft compared receiving matched donor graft versus retransplantation patients graft failure resulted long term survival baseline splenomegaly affect transplantation outcomes given particularly poor outcomes seen unrelated donor cohort elsewhere formal exploration alternative hematopoietic stem cell sources warranted american society blood marrow transplantation
flood events cause substantial damage urban rural areas monitoring water extent large scale flooding crucial order identify area affected evaluate damage events spatial assessments floodwater may derived satellite airborne sensing platforms meanwhile increasing availability smartphones leading documentation flood events directly individuals information shared real time using social media topographic data used determine floodwater accumulate often available national mapping governmental repositories work present evaluate method rapidly estimating flood inundation extent based model fuses remote sensing social media topographic data sources using geotagged photographs sourced social media optical remote sensing high resolution terrain mapping develop bayesian statistical model estimate probability flood inundation weights evidence analysis experiments conducted using data collected flood event focus oxford city surrounding areas using proposed technique predictions inundation evaluated ground truth flood extent results report quantitative accuracy multisource mapping process obtained area receiver operating curve values model fitting testing respectively
multiferroic materials attracted attention scientific community world due smart functionality attractive applications magnetoelectric memory magnetoelectric sensors paper report ferroelectric magnetic magnetoelectric properties microwave sintered bifeo bfo blfmo ceramics ferromagnetic paramagnetic components deconvoluted using standard magnetization equation ferromagnetic saturation paramagnetic susceptibility bfo found emu emu respectively magnetization blfmo increases enormously compared bfo due suppression cycloid spin magnetoelectric voltage coefficient bfo blfmo compared bfo blfmo exhibits improved ferroelectric magnetic magnetoelectric properties elsevier rights reserved
portal hypertension pht major consequence chronic liver disease main cause complications patients cirrhosis measurement hepatic vein pressure gradient considered gold standard pht assessment together diagnosis prognosis relevance even though hepatic vein pressure gradient measurement safe procedure still considered invasive technique widely available thus need noninvasive methods predict progression pht well presence risk complications related esophageal varices review aimed discuss noninvasive markers used assessment pht detection high risk esophageal varices patients liver cirrhosis focus main biomarkers particularly used routine assessment chronic liver disease physical methods use tissue elastography diagnosis tool copyright wolters kluwer health inc rights reserved
mastectomy rates increase overall survival early breast cancer improves better understanding long term consequences mastectomy needed sought explore correlation specific mastectomy type female sexual function index fsfi body image satisfaction reconstructed breast role intimacy study secondary analysis cross sectional survey including retrospective chart review patients least one year primary surgery invited complete survey baseline characteristics survey responses compared three mastectomy groups total modified radical tmrm skin sparing ssm nipple sparing nsm patients underwent reconstruction invited completed survey sixty underwent mastectomy reconstruction tmrm ssm nsm significant differences median total fsfi scores groups yet median fsfi scores nsm group indicated sexual dysfunction adjusting receipt chemotherapy radiation nsm lowest median desire score trend nsm group least satisfied postoperative appearance also likely report chest often caressed intimacy however nearly nsm group reported caress reconstructed breast unpleasant nsm offers patients greatest opportunity preservation native skin envelope potentially enhanced cosmetic outcome results demonstrate superior sexual function body image outcomes group highlighting surgical consequences mastectomy preoperatively surgeons may better set realistic patient expectations regarding aesthetic functional outcomes breast cancer surgery clearer expectations patients better opportunity improved surgical decision making
present case pleural tuberculosis patient infliximab ankylosing spondylitis year old male presented hospital low back ache inflammatory type along multiple symmetric inflammatory type ofjoint pain clinical examination laboratory radiological investigations suggestive ankylosing spondylitis initially treated nonsteroidal anti inflammatory drugs citing poor response decided initiate biologic therapy using infliximab antitumor necrosis factor alpha mantoux test chest radiograph done therapy rule following three doses infliximab patient came complaints fever cough week investigation found case pulmonary shows importance close monitoring patient among patients infliximab even though screening test come negative
efficiency mechanism electron energy transfer events occurring natural synthetic donor acceptor systems depend distance relative orientation nature surrounding media fundamental knowledge gained model studies key building efficient energy harvesting optoelectronic devices faster charge separation slower charge recombination donor acceptor systems often sought continued effort build donor acceptor systems using near sensitizers present study report ground excited state charge transfer newly synthesized directly linked tetrads featuring bisdonor donor phenothiazine ferrocene chelated azadipyrromethane azabodipy entities tetrads synthesized using multi step synthetic procedure revealed strong charge transfer interactions ground state involving donor azabodipy entities near emitting azabodipy acted photosensitizing electron acceptor along fullerene whereas phenothiazine ferrocene entities acted electron donors triads bisdonor azabodipy tetrads revealed ultrafast photoinduced charge separation leading center dot azabodipy center dot center dot azabodipy center dot phenothiazine ferrocene charge separated states femtosecond transient absorption spectral studies polar nonpolar solvent media charge separated states populated triplet excited state azabodipy prior returning ground state
high efficiency high power density buffer architecture proposed power pulsation decoupling power conversion single phase present active decoupling solution yields improved efficiency reduced circuit complexity compared existing solutions proposed architecture main energy storage capacitor connected series active buffer converter across bus series stacked capacitor blocks majority bus voltage reduce voltage stress buffer converter fast low voltage transistors employed buffer converter moreover series capacitor provides majority power pulsation decoupling wide voltage swing buffer converter needs process small fraction total power entire architecture allowing small active circuit volume high system efficiency circuit operation design constraints analyzed detail proposed buffer architecture series stacking nearly lossless capacitor lossy converter presents challenge capacitor voltage balancing power loss compensation propose control scheme exploiting small ripple bus voltage input current compensate power loss buffer converter maintaining voltage balance light load techniques also introduced ensure buffer architecture meets strict ripple requirements providing sufficient loss compensation hardware prototype based low voltage gan switches built demonstrate performance proposed solution power density rectangular box volume efficiency across wide load range experimentally verified
network based real time kinematic nrtk global navigation satellite system gnss technique proposed first time monitor dynamic response bridges could receive corrections established remote continuously operating reference station cors network instead user defined local reference station validate feasibility nrtk gnss technique laboratory field experiments conducted university nottingham wilford suspension bridge footbridge close university campus conventional real time kinematic rtk gnss accelerometer techniques synchronously considered validating accuracy nrtk gnss technique wavelet packet filtering scheme designed process full scale experimental data according characteristics nrtk gnss measurement noise dynamic displacements vibration frequencies bridge successfully identified nrtk gnss data satisfactory accuracy conclusion study confirms proposed nrtk gnss potential technique dynamic monitoring bridges adequate performance lower operational cost powerful monitoring tool structural health monitoring continuous enhancement hardware algorithm
paper presents efficient robust circuital implementation rail rail input stage transconductance control tailored low noise operational amplifiers based differential pairs biased sub threshold region proposed control circuit design indeed based transistors ratio allows efficient control scaled currents dimensions architecture guarantees nearly constant performance terms bandwidth power consumption whole common mode input range power area efficient way achievable precision transconductance control also analyzed transistor equations deviation predicted simple analytical model suggests also strategy minimization error proper tuning prototype input output rail rail operational amplifier fabricated standard cmos technology confirming validity control loop amplifier consumes supply open loop gain gain bandwidth product mhz
project involves development prototype electrical generator delivering storing small amounts electricity power generated using thermoelectric effect single thermoelectric generator teg utilised convert small portion heat flowing electricity electricity produced used charge single rechargeable lithium iron phosphate battery study investigates methods delivering maximum power battery range temperature gradients across thermoelectric module paper explores load matching maximum power point tracking techniques found teg tested sepic converter beneficial temperature gradients less degrees across teg temperature gradient degrees effective resistance battery close internal resistance teg temperature gradients excess degrees converter suggested simple charge protection circuit sufficient elsevier ltd rights reserved
development wheel slip control ground vehicles electric powertrain belongs one challenging problems automotive control engineering realization wheel slip control anti lock brake abs traction control systems complex task case vehicles designed road road conditions situation control strategy must able handle different tyre surface contact dynamics within context presented paper introduces wheel slip control corresponding abs algorithm developed wheel drive sport utility electric vehicle four individually controlled board motors proposed paper particular includes analysis state art solutions road abs description developed abs architecture based direct wheel slip control predictive reactive wheel torque contributions results abs operation vehicle simulator software special attention given braking rough surface procedure system tuning using hardware loop technique experimental results system testing vehicle demonstrator real operational conditions theoretical experimental outcomes confirmed improved functionality developed wheel slip control terms vehicle safety energy efficiency istvs published elsevier ltd rights reserved
purpose present study aimed assess level agreement clinicians routine assessments medication status plasma levels commonly prescribed antipsychotic medications patients presenting emergency room exacerbation psychosis methods studied patients presenting emergency room admitted inpatient psychiatric unit diagnosis schizophrenia schizoaffective disorder bipolar disorder psychotic disorder otherwise specified prior outpatient medication regimen including risperidone olanzapine quetiapine aripiprazole paliperidone plasma levels antipsychotics drawn sent specialty laboratory testing findings patients usable samples found therapeutic antipsychotic levels judged emergency room staff taking medications appropriately prescribed doses whereas judged taking medication sixty four patients found subtherapeutic antipsychotic levels assessed taking medication prescribed emergency assessment medication status predicted therapeutic nontherapeutic antipsychotic levels rates respectively emergency staff assessment statistically independent likelihood therapeutic antipsychotic level implications patients presenting emergency rooms exacerbations psychosis subsequently admitted inpatient facility common assessments medication status frequently misleading readily available methods rapidly measuring antipsychotic plasma levels clinical settings needed clinicians make reliable assessments
wind energy one fastest growing sources sustainable energy production wind turbines coming operation best locations already becoming occupied turbines wind farm developers look new still available areas locations may ideal complex terrain landscapes locations turbulence wind shear higher general wind conditions harder predict also modelling wakes behind turbines complicated makes energy yield estimates uncertain ideal conditions theme issue includes research papers devoted various fluid mechanics aspects using wind energy complex terrains illustrates recent progress future developments important field article part themed issue wind energy complex terrains
present case year old man acute myeloid leukemia developed fevers skin lesion following first cycle induction chemotherapy skin biopsy showed evidence invasive fungal infection cultures remained negative polymerase chain reaction tissue detected rhizopus oryzae complex patient started liposomal amphotericin underwent surgical debridement switched posaconazole plans allogeneic hematopoetic stem cell transplant future
background objectives older adults characterized attentional preference positive negative information since positivity effect considered emotion regulation strategy pronounced emotion regulation needed contrast previous studies focused effects sad mood attention used stressor activate emotion regulation evaluate effects different types mood state changes moreover evaluated mood effects attentional processes using paradigm allows disentangling different attentional engagement disengagement processes methods sixty older adults randomly assigned receive stressor control task manipulation mood state levels happy sad nervous calm assessed next attentional processing happy sad angry faces investigated using eye tracking paradigm participants either engage attention towards disengage attention away emotional stimuli results changes different mood state levels associated different attentional disengagement strategies expected older adults increased sad mood level showed larger positivity effect evidenced longer time disengage attention happy faces however older adults received tension induction decreased calm mood level characterized longer times disengage attention sad faces limitations stressor partially effective led changes calm mood nervous mood conclusions results suggest older adults may deploy positivity effect attention longer times disengage positive information order regulate sad mood effect may hampered confrontation stressors elsevier ltd rights reserved
high psychoticism low psychoticism subject groups matched gender received presentations violent video segment alternating comic video segment video preceded baseline period followed affective rating period skin conductance level scl recorded continuously throughout study group showed strong preference violence compared comedy perceived violent video comical enjoyable lie comic video less comical enjoyable group indications inhibited affect group corresponded faster decline scl group psychoticism groups exhibited distinct patterns electrodermal response violent comic videos consistent respective personality profiles obtained behavioural data group produced largest initial scl increment violence followed rapid habituation group exhibited physiological sensitisation rapid habituation several results showed subjects whole displayed affective electrodermal desensitisation stimulus videos trials findings provide insight general response patterns film violence suggest may important modulator response patterns elsevier science ltd rights reserved
knowledge discovery distributed databases process extracting useful information collection data stored distributed databases distributed database collection data replicated number different computers best suited structures working distributed databases distributed committee machines distributed committee machines combination neural networks work distributed manner group order obtain better performance individual neural networks solving data mining tasks inside kdd process paper aim study interaction distributed committee machines distributed databases process replication multiple machines become slow number machines replication topology grows behavior explicable complex software used real implementations replication process order make available data multiple machines paper propose design overcomes disadvantages new type approach storing neural networks developed system stores entire neural network real relational databases optimized dcm structure eliminates problems inherited replication writing result locally special tables replicated distributed machines used also new approach consists storing entire neural network table blob binary large object object method beneficial also new types elearning techniques adaptive elearning method uses neural networks optimized design dcm structures speedup experiments almost equal number distributed machines used
paper presents second part work concerning dynamic simulation small steam cycle plants power generation work part preliminary study kwe biomass fired steam power plant complete open loop lumped parameter dynamic model steam cycle developed using simecs software described part work low power plants dynamic simulation tool especially useful systems must designed operate transient mode time plant model presented consists following components feedwater pump economizer evaporator superheater impulse turbine electrical generator condenser primary heat source modeled flue gas flow combustion models incorporated yet model furnace description various components forming complete steam cycle given illustrate capabilities modularity developed modeling technique model first validated quantitatively steadystate values obtained using well known reliable steady state process modeling software subsequently dynamic validation presented results discussed based qualitative assessment observed trends measurements available plant preliminary design phase qualitative validation based four dynamic simulations involving three small step disturbances different magnitude imposed pump rotational speed flue gas mass flow single large ramp disturbance flue gas mass flow elsevier ltd rights reserved
metal implants osteosynthesis nowadays standard orthopedic trauma surgery steel implants especially cerclages bands wires show corrosion due friction lead encapsulation connective tissue fluid borders even without loosening corrosion fluid borders potentially susceptible incompatibility infections titanium implants advantage better allergic compatibility problems may occur material removal especially titanium implants material fractures occur frequently particularly fixed angle constructions blocking titanium titanium bonding screws bone occur adhesion ingrowth apart single case reports evidence modern steel implants cause allergic reactions titanium therefore treatment osteosynthesis stability risk loosening manifestation allergies possibility material removal must always considered
objectives investigate immediate effects myofascial induction placebo electrotherapy control perceived pain cervical shoulder range motion rom mood state breast cancer survivors bcss shoulder arm morbidity examine relationships pain modifications cervical shoulder rom side affected breast cancer design randomized single blind placebo controlled crossover study setting physical therapy laboratory participants bcss diagnosis stage iiia breast cancer completed adjuvant therapy except hormonal treatment intervention session bcss received either fascial unwinding intervention focused upper limb area following pilat approach placebo pulsed shortwave therapy control group session lasted minutes adequate washout period weeks sessions established main outcome measures visual analog scale vas pain anxiety shoulder cervical goniometry rom profile mood states psychological distress attitudes towards massage scale used results analysis covariance ancova revealed significant time group interactions vas affected arm vas cervical vas nonaffected arm vas anxiety ancova also revealed significant interactions affected shoulder flexion abduction external rotation internal rotation significant interactions affected cervical rotation affected cervical lateral flexion also found significant negative correlation found changes vas affected arm shoulder arm internal rotation rom conclusions single session decreases pain intensity improves neck shoulder rom greater degree placebo electrotherapy bcss experiencing pain american congress rehabilitation medicine
introduction impulsivity personality trait related control behaviour emotions found different psychopathological alterations including referred eating behaviour objective aim study analyse relationship among influence aesthetic body shape model eating behaviour risk specific disorders body mass index impulsivity method total males included study mean age height weight assessed order obtain body mass index participants fulfilled following questionnaires barratt impulsivity scale bis questionnaire influences body shape model males cimec eating attitudes test results respect possible cases eating disorders found scores items bis correlated significantly eat cimec scores overweight participants showed higher level impulsivity well eat scores cut point test conclusions assessment impulsivity psychological point view might preventive tool regards disordered eating behaviours respecting patients eating disorders overweight obesity assessment might relevant aspect order improve therapeutical approach
rationale dopamine plays central role reward processing accumulating evidence suggests social interaction social stimuli rewarding properties activate reward circuits however studies attempted investigate involved processing social stimuli objectives study investigated effects pharmacological manipulations receptors social nonsocial visual attention preference macaques methods japanese macaques subjected behavioral tests visual attention toward social monkey faces without affective expressions nonsocial stimuli examined antagonist administration results macaques exhibited significantly longer durations gazing toward images social cues nonsocial cues antagonist administration decreased duration gazing toward social images without affective valences addition although antagonist administration increased duration gazing toward nonsocial images antagonism effect conclusions results suggest receptors may roles processing social signals separate mechanisms
background congenital hypothyroidism one major causes physical mental disabilities preventable treatable study aimed investigate physical growth evaluate effectiveness performed therapeutic interventions normality serum tsh levels children yazd city methods retrospective cohort study performed neonates born years growth pattern height weight head circumference first five years children effectiveness performed therapeutic interventions normality serum tsh levels evaluated collected data analyzed using version spss software results pattern height weight head circumference girls comparable growth pattern nchs healthy individuals pattern height weight growth boys gradually became similar growth pattern nchs healthy boys however decline head circumference growth trend six months age also revealed therapeutic interventions appropriate effect normalization serum tsh levels growth pattern children treatment conclusions treatmentandcare patients growth patternsandserumtandtshlevels children reached normal desirable range
chronic myeloproliferative neoplasms mpn comprise spectrum clonal neoplastic disorders characterized overproduction terminally differentiated cells myeloid lineage common genetic basis bcr abl negative mpn disorders elucidated identification jakvf mutation majority mpn patients discovery jakvf dramatic impact diagnosis treatment mpn testing jak mutations included world health organization criteria diagnosis mpn oral jak kinase inhibitor ruxolitinib became first food drug administration fda approved drug treatment myelofibrosis drug also approved europe canada
efficient photoanode doped zno fabricated using economic simple spray pyrolysis technique exhibited fold photocurrent enhancement compared doped photoelectrode irradiated simulated solar radiation photo conversion efficiencies electrodes fabricated variation dopant concentration range estimated compared doping enabled control charge dynamics zno photoanode yield enhanced photocurrent photo electrochemical hydrogen evolution solar photons doped photoanode times larger magnitude similar mol doped film electrodes mol film exhibited wurtzite structure space group pmc show structural lattice deformation doping optical studies revealed red shift band gap decrease absorption coefficient increase concentration photoanodes also displayed higher incident photon current conversion efficiency ipce wavelength range electrochemical studies revealed type conductivity photoanodes anodic shift flat band potential observed increase dopant concentration zno lattice result experimental study illustrated form schematic diagram demonstrates suitability doped system solar hydrogen generation dopant induced improved optical absorption mainly attributed enhancement photo response doped zno films study indicates high potential zno films solar energy applications especially respect ability work solar radiation hydrogen energy publications llc published elsevier ltd rights reserved
consideration paper volterra lattice system symbolic computation lax pair conservation laws derived integrable lattice hierarchy fold darboux transformation constructed system furthermore soliton solutions terms determinant generated resulting fold structures one two three soliton solutions shown graphically overtaking inelastic solitonic interactions among two three solitons discussed figures plotted
calcitonin gene related peptide monoclonal antibodies cgrp mabs shown promise preventive treatment migraine therefore performed meta analysis evaluate efficacy safety cgrp mabs preventive treatment migraine database including ovid cochrane library pubmed web science isi systematically searched april randomized controlled trials rcts dealing efficacy safety cgrp mabs preventive treatment episodic migraine cochrane collaboration tool assessing risk bias utilized evaluating bias quality rcts data analyzed reviewer manager totally literatures matched inclusion criteria including independent rcts patients among mentioned amg monoclonal antibody cgrp receptor ald tev monoclonal antibody cgrp found amg reduce monthly migraine days baseline week amg could reduce monthly migraine days baseline week significantly compared placebo meanwhile pooled estimate efficacy cgrp mab cgrp found cgrp mabs improved decrease monthly migraine days baseline week compared placebo wmd cgrp mabs improved decrease monthly migraine days baseline week matter single dose subgroup wmd multiple doses subgroup wmd difference incidence adverse events cgrp mab group placebo group conclusion cgrp mabs safety effective preventive treatment episodic migraine elsevier rights reserved
purpose purpose paper evaluate management development programme ghanaian mining industry legal requirement aimed equipping national managers eventual takeover management industry expatriates programme analysed ascertain willingness implement state implementation multinational companies operation industry design methodology approach study employs critical discourse analysis cda problemidentification problem solving analytical tool identify obstacles suppressing implementation possible ways past obstacles data analysis collected national managers industry interviewed gather views expectations development findings key findings include domination hegemonic dynamics expatriates sustained power control process cda emancipatory power succeeds identifying unrealised possibilities tackling problem social change development national managers industry non implementation programme contributed expatriates government ghana senior national managers social implications programme potential developing national managers eventual takeover expatriates requires implementing law latter including denying foreign subsidiaries mining lease fail provide adhere localisation plans originality value paper extends literature management western multinational subsidiaries developing countries revealing power control human resource practices foreign subsidiaries also contributes literature suppression indigenous employees indigenous employees colonised elites contrary expected indigenous people towards development colleagues
macroporous copolymers poly glycidyl methacrylate ethylene glycol dimethacrylate pgme various crosslinker ethylene glycol dimethacrylate concentrations porosity parameters additionally functionalized hexamethylene diamine pgme tested potential oxyanion sorbents aqueous solutions kinetics sorption investigated temperature range results fitted chemical reaction particle diffusion models sorption obeys pseudo second order model definite influence pore diffusion temperature rise promotes chromium removal maximum experimental uptake capacity mmol sample highest amino group concentration equilibrium data analysed langmuir freundlich temkin adsorption isotherm models thermodynamic parameters gibbs free energy enthalpy entropy change activation energy sorption calculated adsorption onto pgme found spontaneous endothermic increased randomness system desorption experiments show chromium anion sorption reversible pgme sample gma easily regenerated mol naoh recovery fourth sorption desorption cycle fifth cycle substantial sorption loss observed society chemical industry
dental problems among athletes cautioned due negative impacts oral health also athletic performance acquirement appropriate oral health behavior mainly composed toothbrushing childhood one important strategies advancing children athletic possibilities although habits screen viewing including game playing viewing direct impacts children health behavioral development little known association habits toothbrushing frequency cross sectional survey examining sports activities conducted using self report questionnaire among school aged athletic children belonging miyagi amateur sports association statistical analyses performed spss values less considered statistically significant association lower brushing frequency hrs day viewing significantly correlated lower brushing frequency trend importantly longer game playing behavior also associated unhealthy dental behavior defined lower brushing frequency regardless awareness dental caries trend conclusion first study indicating type specific unfavorable impact screen viewing oral health behavior among athletic children excessive game playing may adversely affect oral health literacy strongly viewing
cooperation among individuals depends large part sense fairness many cooperating nonhuman primates show inequity aversion negative responses unequal outcomes responses towards inequity probably evolved means preserve advantages cooperative relationships however marmosets callithrix spp tend show little inequity aversion despite high occurrence prosociality cooperative breeding callitrichid monkeys oxytocin oxt implicated wide variety social processes little known whether oxt modulates inequity aversion towards others used tray pulling task evaluate whether marmosets would donate superior rewards long term pair mate opposite sex stranger following oxt oxt antagonist saline treatments found marmosets show inequity aversion inequity aversion socially sex specific male marmosets showed inequity aversion towards pair mates towards strangers female marmosets show inequity aversion oxt treatments significantly influence inequity aversion marmosets oxt may modulate prosocial preferences motivations underlying cooperative relationships inequity aversion multifaceted research needed evaluate evolutionary origins biological processes social contexts influence complex phenotypes like inequity aversion inequity aversion differ within species important distinct ways including individuals share cooperative relationship overall findings support view inequity aversion important behavioural strategy maintenance cooperative relationships association study animal behaviour published elsevier ltd rights reserved
system made connection broadband amplifier opa current feedback operational amplifier opa attenuation network filter circuit mcu gain control module first stage system achieve times fixed gain opa intermediate stage made connection two opa achieve times gain latter part system achieves similar gain variation opa attenuation network last stage system achieves gain reduction high pass filter network atc used control gain adjustment system well real time display present output voltage gain range gain similar changed step step testing whole system stable performance good control
theory research point role attachment difficulties borderline personality disorder bpd attachment insecurity believed lead chronic problems social relationships attributable part impairments social cognition comprise maladaptive mental representations self others self relation others however studies attempted identify social cognitive mechanisms link attachment insecurity bpi assess whether mechanisms specific disorder present study empirically derived indices mentalization self boundaries identity diffusion tested mediators attachment style personality disorder symptoms cross sectional structural equation model mentalization self boundaries mediated relationship attachment anxiety bpd mentalization partially mediated relationship attachment anxiety antisocial personality disorder symptoms self boundaries mediated relationship attachment anxiety avoidant symptoms findings support theories insecure attachment associated difficulties social cognition distinctive pattern impairment characterizes bpd
use ultrasound imaging alternative real time computer assisted interventions increasing growing usage occurs despite lower imaging quality compared techniques difficulty used image analysis algorithms hand still difficult find sufficient data develop assess solutions navigation registration reconstruction medical research level present manually acquired available datasets present significant usability obstacles due lack control acquisition conditions hinders study correction algorithm design parameters address limitations present database robotically acquired sequences images medical phantoms ensuring trajectory pose force control probe acquired dataset publicly available specially useful designing testing registration volume reconstruction algorithms
background stress generation hypothesis posits individuals psychopathology engage maladaptive behaviors create stress although extensively researched depression literature studies investigated whether stress generation hypothesis applies eating disorders study examined whether bulimic symptoms dietary restraint predict future life hassles low social support among undergraduate students methods three hundred seventy four undergraduate students participated two part prospective study secure online system completed questionnaires assessing depressive symptoms bulimic symptoms dietary restraint life hassles social support results regression analyses revealed baseline bulimic symptoms predicted greater life hassles lower social support one month later statistically controlling baseline measures baseline dietary restraint predict future life hassles social support limitations limitations include use self report measures suboptimal response rates follow assessment use non clinical sample primarily white participants conclusions results provide preliminary support stress generation hypothesis relation bulimic symptoms individuals bulimic symptoms may generate stressors similar experiencing depressive symptoms findings suggest emphasizing stress management treatment individuals bulimic symptoms could potentially improve treatment outcomes elsevier rights reserved
paper describes identification technique control oriented linear time invariant models coupled dynamics electron temperature poloidal magnetic flux advanced operational tokamak scenarios actuators consist two neutral beam injectors electron cyclotron current drive ohmic coil provides loop voltage plasma surface model identified using combination subspace output error methods state space multiple input multiple output system identification identification applied sets simulated data metis tokamak simulator parameters typical diii tokamak results identification presented
analizes extent certain personality profiles associated incidence sports injuries presents quantitative study correlational descriptive athletes men women practitioners team sports individual sports assessed competitive anxiety competitiveness well number severity sports injuries results suggest athletes whose profiles higher number injuries manifesting high motivation oriented success along high motivation avoid failure addition injured athletes lower competitive anxiety group injured results discussed
background despite durable viral suppression afforded antiretroviral therapy hiv eradication require strategies target latently infected cells persist infected individuals protein kinase pkc activation promising strategy reactivate latent proviruses allow subsequent recognition clearance infected cells immune system ingenol derivatives pkc agonists induce latency reversal also lead cell activation release pro inflammatory cytokines would undesirable vivo work sought identify compounds would suppress pro inflammatory cytokine production context pkc activation design methods performed vitro screen identify compounds could dampen pro inflammatory cytokine release associated cell activation using model cytokine tested ability promising screening hit fda approved janus kinase jak inhibitor ruxolitinib diminish release multiple cytokines effect latency reversal using cells hiv positive aviremic participants results demonstrate administration ruxolitinib ingenol dibenzoate significantly reduces pro inflammatory cytokine release without impairing latency reversal vivo conclusion combination ingenol compounds jak inhibition represents novel strategy hiv eradication
background evaluations clinical depression traditionally based verbal information nonverbal expressive behavior however associated person reflexive responses may reveal negative emotional social processes complete control patients however investigations nonverbal behavior evaluation depressed patients still scarce study examines nonverbal behaviors group brazilian patients associating nonverbal behavior severity depression methods forty depressed patients evaluated baseline two week transcranial direct current stimulation treatment according rating scales category ethogram assessment frequency nonverbal behaviors displayed interview results behaviors related negative feelings social disinterest decreased corresponding clinical improvement associated increased severity symptoms greater negative affect dissatisfaction pro social behaviors associated milder symptoms increased treatment facial head hand expressive movements stood important indicators associations severity depression limitations duration behaviors assessed healthy control group compare findings conclusions results support usefulness nonverbal behavior evaluation technique assessment clinical depression elsevier rights reserved
due increasing prevalence diabetes well increasing management costs artificial control diabetes highly important task model based design allows finding effective solutions individual treatment diabetic patients robustness important property hardly guaranteed already developed individualized control algorithms modern robust control known ham theory represents efficient possibility solve robustness requirements general way based exact mathematical formulation linear matrix inequalities combined knowledge based expertise real patient data uncertainty weighting functions formulated difference nominal model real patient dynamics bounded known approach becomes highly reliable however requirement poses greatest limitation since model always represents approximation complex physiological process consequently uncertainty formulation neglected dynamics becomes crucial robust methods sensitive order formulate large amount real patient data medical expertise needed cover different life style scenarios especially worst case ones define control space accumulated knowledge hand infinity based methods represent linear control techniques hence direct nonlinear application important physiological process paper presents roadmap using modern robust control diabetes focusing nonlinear model based interpretation weighting functions selected based knowledge based medical expertise direct nonlinear applicability method taking additional advantage recently emerged linear parameter varying lpv methodology robust performance investigation switching control possibilities control characteristics discussion trade medical knowledge based empiricism exact control engineering formulation introduced different examples computed matlab real diabetic patient data author published elsevier
aim study association vitamin level hospitalization rate crohn disease patients methods designed retrospective cohort study using adult patients years followed least one year inflammatory bowel disease center vitamin levels divided low mean vitamin level appropriate mean vitamin level generalized poisson regression models gpr rate data used estimate partially adjusted fully adjusted incidence rate ratios irr hospitalization among patients also examined irrs vitamin level continuous variable results patients patients vitamin level observation period included partially adjusted model demonstrated patients low mean vitamin level almost twice likely admitted irr compared appropriate vitamin level fully adjusted model confirmed association irr partially adjusted model vitamin level continuous variable demonstrated higher mean vitamin level associated lower likelihood admission every unit rise mean vitamin level irr fully adjusted model confirmed association irr conclusion normal adequate vitamin stores may protective clinical course however role needs characterized understood
describe measuring transducer electrical conductivity liquids used laboratory conditions also study ocean processes natural conditions transducer represented form separate unit laboratory investigations used part deep water hydraulic probe example different processes flows ipmekh ran laboratory fluid mechanics shown small scale transducer high speed high spatial resolution
neurons trigeminal mesencephalic nucleus vme axon branches peripherally innervate orofacial region projects centrally trigeminal motor nucleus vmo function primary neurons conveying proprioceptive messages present study aimed demonstrate presence periodontal vme vmo circuit provide evidence involvement experimental unilateral anterior crossbite uac model induce osteoarthritis temporomandibular joint cholera toxin subunit ctb injected inferior alveolar nerve rats help identify central axon terminals vme neurons vmo levels vesicular glutamate transporter vglut expressed periodontal region vme vmo masseter level acetylcholinesterase ache expressed masseter assessed uac rats controls ctb treated rats many ctb labeled cell bodies endings identified vme vmo respectively uac rats vglut expressed statistically significantly higher level periodontal ligament vme vmo masseter control rats level ache protein times higher uac rat masseter compared control rat masseter findings reveal trigeminal mechanism underlying masseter hyperactivity induced altered occlusion
avalanche photodiode apd receiver intersatellite laser communication links proposed performance experimentally demonstrated proposed system series analog circuits used adjust temperature control bias voltage also monitor current recover clock communication data addition temperature compensation multiplication gain control algorithm embedded microcontroller improve performance receiver shown experiment change communication rate mbps detection sensitivity apd receiver varies dbm moreover due existence multiplication gain control algorithm dynamic range apd receiver effectively improved dynamic range mbps respectively result experimental results agree well theoretical predictions receiver improve flexibility intersatellite links without increasing cost society photo optical instrumentation engineers spie
firstly given security problems faced detailed analysis cognitive radio networks introduces related basic cognitive radio network problems based difference cognitive radio network existing wireless network analyzes security artificial intelligence dynamic spectrum access discussion concluded safety cross layer design
elections casts ennobling influence minds people forms prominent feature country india every individual participates vigilantly populace remains sovereign power world experimenting diverse technologies conduct controversy free elections fulfill elementary needs people taken account elector disenfranchised voting rights main objective design model provide equitable elections project baseline information stored rfid tag provides topical reference data mediate intensive computational prerequisite also provides easy match card sui generis feature meet constraint eligible voters cast vote moreover added tier security enforced bio metrics seen noticeable diminution turnout rate voters especially youth foster participation among demographic groups design looks multiple dimensions notes security requirements provides inexpensive solution based rfid gsm fingerprint module quest election legitimacy
paper presents new infrastructure creating specialized databases database management systems dbmss principles infrastructure formulated based analysis various nosql solutions main features proposed approach flexible system type definitions allows one create data structures based different paradigms different forms supporting structured data mapping onto file system experiments carried implement rdf graphs relational tables name tables object relational mappings proposed approach allows one solve certain problems developing new technologies working big data
paper presents three stage cmos operational amplifier amp class output stage designed silterra cmos technology designed three stage amp employed indirect feedback compensation technique produces open loop gain aol schematic layout respectively amp produces mhz gain bandwidth product gbw degrees phase margin slew rate load furthermore amp capability drive load produces mhz gbw degrees circuit operated single supply voltage power consumption layout area
objective pilot project designed develop procedures test feasibility implementing cognitive enhancement therapy cet group home environment goal maximizing treatment efficacy augmenting social engagement group cet sessions ongoing social interaction methods six participants met criteria including chronic schizophrenia recruited group home residents two months cet pre posttest measures including cognitive tests administered qualitative interviews conducted periodically interaction observed house staff members interviewed focus group results five initial six participants completed intervention continued total weeks engaging weekly group cet sessions computer exercises outside formal sessions participants liked computer exercises one participated reported enjoying group exercises observations staff comments indicated increased social interaction sustained impact residents aspects cognitive functioning improved participants initial two months conclusions cet needs tested formally determine delivered successfully group homes manualized procedure idea tested feedback effects due sustained social contact may enhance effectiveness cet group homes lead larger sustained gains community functioning clinicians provide cognitive interventions focus attention social context treatment delivered consider providing treatment patient groups whose daily ongoing social interaction enhance effects elsevier rights reserved
ambient intelligence ami deals new world ubiquitous computing devices physical environments interact intelligently unobtrusively people ami environments diverse homes offices meeting rooms schools hospitals control centers vehicles tourist attractions stores sports facilities music devices paper present design implementation testbed ami using raspberry mounted raspbian analyze performance means clustering algorithm evaluation considered respiratory rate heart rate metrics simulation results show means clustering algorithm good performance
primary use imaging focuses diagnostic evaluation pelvic radiography still primary modality evaluation disease sacroiliac joints unreliability inability directly assess inflammation led increasing use magnetic resonance imaging mri directly assesses inflammatory changes well structural changes associated inflammation radiography mri therefore incorporated new classification criteria designed capture early established spondyloarthritis fat metaplasia weighted mri important intermediary tissue pathway inflammation ankylosis sacroiliac joints spine
photocatalytic reduction attracted enormous research interest provides clean low cost way removal toxic despite tremendous efforts present great challenge materials science develop highly efficient photocatalysts reduction low cost reported new composite materials consisting sns quantum dots qds grown reduced graphene oxide rgo highly efficient photocatalysts photocatalytic reduction visible light irradiation nanostructured materials prepared simple cost effective one step hydrothermal process using stannic chloride pentahydrate cysteine graphene oxide precursors photocatalytic performance sns qds rgo composite photocatalysts reduction investigated results showed sns qds rgo photocatalysts exhibited significantly enhanced photocatalytic activities reduction sns qds rgo photocatalyst achieved highest photoreduction efficiency visible light irradiation enhanced photocatalytic activities sns qds rgo photocatalysts mainly due excellent electron transportation ability graphene impedes recombination electron hole pairs effective charge transfer sns grapheme demonstrated significant reduction photoluminsence intensity sns qds rgo photocatalysts present study suggests sns qds rgo photocatalysts potential photoactived materials efficient use solar energy removal elsevier rights reserved
main purpose research examine relationships among school principals transformational leadership school academic optimism teachers academic optimism teachers professional commitment study conducted questionnaire survey teachers high schools taiwan random sampling using principals transformational leadership scale school academic optimism scale teachers academic optimism scale teachers professional commitment scale results confirmatory factor analysis showed good fit factor structure school academic optimism teachers academic optimism results pearson product moment correlation analysis path analysis revealed principals transformational leadership positive effect school academic optimism teachers academic optimism school academic optimism positive effect teachers academic optimism principals transformational leadership teachers academic optimism positive effect teachers professional commitment finally research offers suggestions based results
environmental issues become prominent electric vehicles attracted increasing amount attention however continuous cruising distance limited approximately insufficient everyday use battery capacity limiting factor long distance travel vehicles need stop recharging stations multiple times japan charge stations two rapid chargers multiple users converge station queuing waiting condition created may lead call loss condition words appropriate number chargers must installed station planning infrastructure therefore number vehicles entering station must estimated study mathematical model based supporting infrastructure widespread use proposed estimate number vehicles arriving charge station
recommendation system software engineering rsse software application provides information items estimated valuable software engineering task given context present results systematic literature review reveal typical functionality offered existing rsses research gaps possible research directions evaluated papers studying benefits data requirements information recommendation types effort requirements rsse systems include papers describing tools support source code related development published results show rsses typically visualize source code artifacts aim improve system quality make development process efficient less expensive lower developer cognitive load help developers make better decisions mainly support reuse actions debugging implementation maintenance phases majority systems reactive unexploited opportunities lie development recommender systems outside source code domain furthermore current rsse systems use limited context information rely simple models context adapted proactive behavior could improve acceptance rsse systems practice elsevier inc rights reserved
nowadays healthcare main advancement upcoming technology healthcare industry contributes setting automated efficient healthcare infrastructures unfortunately several security aspects remain main challenges towards secure privacy preserving healthcare systems access control perspective healthcare systems face several issues due necessity defining time rigorous flexible access control solutions delicate irregular balance flexibility robustness immediate impact compliance deployed access control policy address issue paper defines general framework organize thinking verifying validating monitoring compliance access control policies context healthcare databases study problem conformity low level policies within relational databases particularly focus case medical records management database defined context medical information system propose advanced solution deploying reliable efficient access control policies solution extends traditional lifecycle access control policy allows mainly managing compliance policy refer example illustrate relevance proposal
composite frequency selective surface fss fabricated using beam evaporator proposed manufacturing process advantageous directly achieve fss function real structural surfaces various skin conformations multilayered patch grid patch type fss consisting copper layers capacitive inductive surfaces glass epoxy prepreg substrate produced operates ghz dual polarisation technique used manufacture stealth technology communicating specific frequency range
several studies demonstrated women show greater interest social information empathic attitude men article reviews studies sex differences brain particular reference males females process faces facial expressions social interactions pain others infant faces faces things pareidolia phenomenon opposite sex faces humans landscapes incongruent behavior motor actions biological motion erotic pictures emotional information sex differences oxytocin based attachment response emotional memory also mentioned addition investigated different human faces evaluated arousal valence dimensions group healthy male female university students stimuli carefully balanced sensory perceptual characteristics age facial expression sex whole women judged human faces positive arousing men furthermore showed preference faces children elderly arousal evaluation regardless face aesthetics age facial expression women rated human faces higher men preference opposite sex faces strongly interacted facial age overall women men exhibited differences facial processing could interpreted light evolutionary psychobiology wiley periodicals inc
emission cerium oxide nanoparticles ceo diesel engines using cerium compounds catalyst lower diesel exhaust particles health concern previously shown ceo induced pulmonary inflammation lung fibrosis objective present study investigate modification fibroblast function role epithelial mesenchymal transition emt ceo induced fibrosis male sprague dawley rats exposed ceo single intratracheal instillation sacrificed various times post exposure results show days ceo exposure lung fibrosis evidenced increased soluble collagen bronchoalveolar lavage fluid elevated hydroxyproline content lung tissues enhanced sirius red staining collagen lung tissue lung fibroblasts alveolar type atii cells isolated ceo exposed rats days post exposure demonstrated decreasing proliferation rate compare controls ceo exposure cytotoxic altered cell function demonstrated fibroblast apoptosis aggregation atii cell hypertrophy hyperplasia increased surfactant presence stress fibers expressed smooth muscle actin sma ceo exposed fibroblasts atii cells significantly increased compared control immunohistofluorescence analysis demonstrated localization tgf beta alpha sma prosurfactant protein spc stained atii cells results demonstrate ceo exposure affects fibroblast function induces emt atii cells play role lung fibrosis findings suggest potential adverse health effects response ceo nanoparticle exposure elsevier inc rights reserved
patients breast cancer related lymphedema bcrl need life long self care program adhere enable manage lymphedema objective study assess effectiveness holistic bcrl self care program patients could easily adhere comply prospective longitudinal comparative study affected arms unaffected arms unilateral breast cancer patients implemented six month period lymphedematous unaffected arms patients unilateral bcrl followed measured daily minute holistic bcrl self care program consisted modified japanese rajio taiso japanese radio calisthenics gentle arm exercise combined deep breathing skin moisturizing care using traditional lymphatic drainage technique basic self care education arm edema volume relative volume change resistance skin compression fibrosis lymphedema related symptoms skin condition self care assessed end six months volume limb segments resistance tissues compression measurement points affected arm significantly reduced unaffected side volume forearm whole arm significantly reduced fibrosis significantly reduced forearm significant difference edema volume relative volume change lymphedema related symptoms significantly improved perceived adherence effectiveness burden score average time self care significantly increased results demonstrate minute self care program may improve bcrl self care
background systemic lupus erythematosus sle antiphospholipid antibody syndrome aps autoimmune diseases affect women childbearing age maternal igg antiphospholipid antibodies apl cross placenta pregnancy theoretically reach fetal brain studies showed increased number learning disabilities children objectives evaluate long term neurodevelopmental outcome children median age years born mothers sle aps carrying positive igg apl third trimester pregnancy methods children checked neurological physical exam intellectual cognitive functioning wechsler scale corrected age submitted mothers child behavior checklist cbcl homemade set questions created pediatric neurologists results children neurological physical exam intelligence levels found normal cognitive impairment discrepant cognitive profile found children respectively learning disabilities diagnosed children school age children born mothers triple apl positivity history epilepsy shown four children conclusions children born women sle aps may need long term follow focusing milestones neurodevelopment order detect correct alteration early possible
causal link tourism receipts gdp recently become major focus tourism economics literature results obtained recent studies causal link appear sensitive respect countries analysed sample period methodology employed considering sensitivity causal link use rolling window time varying coefficient estimation methods analyse parameter stability granger causality based vector error correction model vecm applied south africa period findings follows results full sample vecm indicate granger causality tourism receipts gdp findings time varying coefficients model based state space representation show tourism receipts positive predictive content gdp entire period exception period full sample time varying causality tests show bidirectional strong causality tourism receipts gdp
irritable bowel syndrome ibs one prevalent gastrointestinal disorders developed countries etiology remains unknown however common finding regardless ibs subtype presence altered intestinal barrier fact signaling location cell cell adhesion proteins connection increased immune activity seem abnormal intestinal epithelium ibs patients despite research performed distal segments intestine altered permeability reported small large bowel ibs subtypes small intestine carries digestion nutrient absorption also site majority immune responses luminal antigens takes place fact upper intestine exposed environmental antigens colon also site symptom generation recent studies revealed small intestinal structural alterations epithelial barrier mucosal immune activation association intestinal dysfunction suggesting commitment intestine whole pathogenesis ibs review summarizes recent findings mucosal barrier alterations relationship symptoms arising small intestine ibs including epithelial structural abnormalities mucosal immune activation microbial dysbiosis supporting hypothesis organic origin ibs
present work aims provide first principles insights catalytic performance composites based batio particles decorated reduced graphene oxide rgo examination regarding orbital contributions valence states conduction states interaction surface anchoring perovskite rgo carried theoretical results thus obtained validated using experimental investigation experiments also conducted analyze catalytic performance composites respect multiple advanced oxidation processes charge separation improved due rgo acting macromolecular photosensitizer degradation xanthene dye rhoda mine methyl orange assisted evaluation catalytic performance acoustic irradiation provides additional route improve degradation ameliorating catalytic activity min min rhb especially synergistic effect obtained conjugated benefits oxidation processes proposed composite played crucial role improving overall efficiency cumulative outcome results indicates superior performance batio rgo composites green sustainable water treatment applications elsevier ltd rights reserved
development science technology progress electronic information technology accepted public network information popularization internet plus also become hot topic campus network become standard configuration daily life study application computer mobile phone also extensive life gradually eroded network today network security issues attention circles society become one main existing problems campus network campus network faces problem network security becoming serious effectively protect network security problem become key problem set firewall anti virus software strengthen identity authentication data encryption effective protection measures paper present safety hazards protective measures campus network analyzed
background polypharmacy important concern patient safety associated increased adverse drug reactions hospitalization mortality elderly objective light present study aimed assess major characteristics associated polypharmacy drugs larger population apparently healthy older subjects years study design cross sectional study setting preventive medical center cmp nancy participants volunteers women men aged years older years included senior health examination study measurements subjects underwent clinical biological examinations sociodemographic data practice regular physical activity drug intake data collected self administered questionnaire health status psychological status questions regarding falls collected results prevalence polypharmacy study number drugs polymedicated people versus non polymedicated people multivariate analyses identified independent variables associated polypharmacy age years poor self perceived health status history falls lack physical activity metabolic syndrome low medium education level conclusion among community dwelling people aged years addition presence several diseases advanced age psychological socio educative factors may influence drug intake polypharmacy elderly physicians take account considerations issuing prescriptions review medications used every visit avoid unnecessary addictions dangerous drug drug interactions
importance attached issues agriculture china infrastructure construction projects countryside water conservancy project important one infrastructure promote sustained stable development countryside also guarantee food security china correspondingly improve rural economic development incomes peasants however small water conservancy projects countryside china problems might cause failure rural development keep step demand era therefore required take corresponding measures specific problems promote development china paper analyzes problems small water conservancy projects countryside china strives improve work efficiency engineering construction management
since eddy current problem usually depends geometry moving conductive sheet pole shape general method solving analytically paper presents method analysis eddy current special case rotating disk time invariant field analysis uses coulomb law method images consider boundary conditions first surface charge generated rotating disk obtained coulomb law applied calculate electric field intensity assuming infinite disk radius second finite disk radius taken account introducing imaginary electric field intensity satisfy boundary condition radial component eddy current zero edge rotating disk third braking torque calculated applying lorentz force law paper compares computed braking torque experimental results establish validity model
paper focus heavy tailed stochastic signals generated continuous time autoregressive car models excited infinite variance alpha stable processes goal estimate parameters continuous time model autoregressive coefficients distribution parameters related excitation process alpha stable car process alpha based state space representation likewise investigate closed form expressions parameters equivalent model discrete time setting via regular samples process analyze estimator based monte carlo simulations illustrate estimator consistency desired values sampling frequency sample size tend infinity also apply proposed method two types real world data financial ground magnetometer data evaluate performance real environments elsevier inc rights reserved
current study aims evaluate capabilities soil water balance modeling estimate different conditions rainfed grapevine water status within vineyard landscape depicts heterogeneities canopy soil water table conditions calibrated hydrus model measurements soil moisture profile within seven contrasted sites validated hydrus sim ulations estimates derived eddy covariance measurements within two contrasted sites analyzed temporal dynamics hydrus simulations throughout almost two growth cycles seven sites calibration hydrus correctly achieved relative rmse average validation hydrus simulations measurements satisfactory rmse values hourly timescale daily timescale hydrus able provide consistent time series within seven contrasted sites throughout two growth cycles conclude hydrus simulations used alternative measurements within rainfed vineyards alleviate experimental efforts device cost maintenance hydrus simulations used characterizing spatial variabili ties temporal dynamics assessing impact pedological conditions land use validating remote sensing retrievals regional extents elsevier rights reserved
objective sedentary behavior associated poor cognitive performance general population although people schizophrenia highly sedentary experience marked cognitive impairments study investigated relationship cognition people schizophrenia methods total inpatients schizophrenia mean age years male mean illness duration age sex matched controls recruited sedentary behavior physical activity captured consecutive days accelerometer cognitive performance assessed using vienna test system grooved pegboard test multivariate regression analyses adjusting important confounders including positive negative symptoms illness duration medication conducted results patients schizophrenia engaged significantly controls min per day performed worse cognitive performance measures compared patients high levels patients lower levels significantly better motor reaction time cognitive processing fully adjusted multivariate analysis independently associated slower motor reaction time beta cognitive outcomes lower levels independently associated worse attention processing speed conclusion data suggest higher levels sedentary behavior physical inactivity independently associated worse performance across several cognitive domains interventions targeting reductions increased explored
construction projects critical path method cpm mainly used project scheduling planning past main objective cpm find critical activities schedule project way project makespan minimized resource allocation project scheduling problem one popular issues among construction management researchers past decades resource leveling problem real world also important considered planning project side since two objectives opposite goals projects considering objectives simultaneously always challenging problem paper try solve problems time purpose two new metaheuristic algorithms called colliding body optimization charged system search utilized two case examples solved show applicability performance considered algorithms
numerous studies examining various manners female managers subjected negative stereotypes bias bias influences hiring decisions sought study job selection challenge within specific context project management discipline historically viewed male dominated focusing perceived differences male female job candidates based set critical personal managerial characteristics including perceived competence trust likeability lack perceived self interest developed scenario based survey questionnaire subjects research design sampled project management personnel tested subjects reactions two candidates project management position employing identical descriptions language changing candidate name susan stan results suggested independent variables significant predictors likelihood project manager candidate hired found evidence gender bias relation perceived technical competence situations perceived technical competence job candidate low female candidate less likely hired male counterpart hand candidate perceived technical competence increased resulting attributions significantly beneficial female job seeker likely hired male candidate elsevier ltd apm ipma rights reserved
paper first analyzed course setting programming computer major discussed problems exist computer programming course put forward course integration scheme according actual situation thinking teaching reform improve quality program design course teaching cultivate students innovation ability
completed systematic review literature related parent knowledge children sleep determine much parents know typical child sleep symptoms related sleep problems childhood parent knowledge assessed also examined whether relationships reported parent knowledge children sleep parent education child sleep problems sleep duration sleep hygiene extensive literature search five electronic databases conducted articles identified eight met inclusion criteria review four descriptive studies four educational interventions studies varied considerably number items included scales specific content measured response scales used populations included limiting conclusions could drawn across studies general parent knowledge child sleep poor greater accuracy reported items pertaining healthy sleep practices sleep onset daytime symptoms comparison items pertaining child sleep problems night knowledgeable parents likely report children exhibited healthy sleep practices associations sleep duration mixed small interventions demonstrated increase parental knowledge short term effects maintained follow future work needed clarify relations parental knowledge child sleep design evaluate effective methods promoting education child sleep range parent populations development validated tools assess parent knowledge child sleep required underpin work elsevier ltd rights reserved
purpose reviewcurrently dramatic changes allergy treatment observed many countries availability monocomponent products pharmaceutical quality sublingual immunotherapy likely strong impact immunotherapy practices specialty general market patient named products allergenic mixtures expected shrink allergists concerned possibility single source products immunotherapy might insufficient serve needs polyallergic patients recent findingsthe availability molecular ige testing novel diagnostic tool clarify much previously perceived polyallergy interpreted pseudo polyallergy predicted needs vast majority polysensitizations met novel allergen components marketing subcutaneous immunotherapy sublingual immunotherapy countries compounding patient tailored allergen extracts traditionally practiced diagnostic therapeutic procedures currently challenged recent survey allermix europe suggests allergists believe vast majority polyallergic patients adequately treated registered products without compounding compounding allergists allergen manufacturers still necessary limited number patients several independent allergies summaryit appears limited portfolio aligned health authority recommendations sufficient answer treatment habits allergists even polysensitized patients
gain understanding factors affect risks adoption risk control measures care bariatric patients focus groups conducted rural metropolitan locations australia found manual handling injury risk carers influenced design environments within patient movement undertaken limited range handling equipment available use bariatric patients efficacy organizational procedures training adoption risk controls hampered absence standard definition term bariatric limitations use weight body mass index definitions gaps information flow bariatric patient journey health care system lack knowledge safely manage unique needs bariatric patients
imaging manifestations hematological diseases potential complications broad may significant overlap features various disease processes knowledge appropriate choice imaging test pertinent imaging patterns pathophysiology disease help reader increase specificity diagnosis treatment patient importantly encourage readers review engage radiologists diagnostic treatment management phases care delivery
stable molecular structure aminonicotinamide ana molecule predicted conformational analysis vibrational spectral analysis carried experimental theoretical methods calculated experimentally observed vibrational frequencies assigned compared star electronic transition molecule predicted theoretically calculated ultraviolet visible spectra gas liquid phase validated experimentally using ethanol solvent frontier molecular orbitals analysis carried probe reactive nature ana molecule site selectivity specific chemical reactions effectively analyzed fukui function calculation molecular electrostatic potential surface simulated confirm reactive sites molecule natural bond orbital analysis also performed understand intra molecular interactions confirms bioactivity ana molecule neuroprotective nature ana molecule analyzed molecular docking analysis ana molecule identified good inhibitor alzheimer disease elsevier rights reserved
objective goal examine association violence media expression seriously violent behavior among older children teenagers national sample methods growing media survey national online survey youths conducted august september participants year old youths used internet least past months main outcome measure self reported seriously violent behavior including shooting stabbing someone aggravated assault robbery sexual assault results five percent youths reported engaging seriously violent behavior past months thirty eight percent reported exposure violence online exposures violence media online line associated significantly elevated odds concurrently reporting seriously violent behavior compared otherwise similar youths indicated many web sites visited depicted real people engaged violent behavior significantly likely report seriously violent behavior adjustment underlying differences youth characteristics respondents alcohol use propensity respond stimuli anger delinquent peers parental monitoring exposures violence community also associated significantly increased odds concurrently reporting seriously violent behavior conclusions exposure violence media associated concurrent reports seriously violent behavior across media games music newer forms violent media seem especially concerning pediatrics
number elderly chronically ill patients grown significantly past decades life expectancy increased worldwide leading increased demands health care system significantly taxing traditional health care practices consequently urgent need use technology innovate constantly intensely monitor report analyze critical patient physiological parameters beyond conventional clinical settings efficient cost effective manner paper presents technological platform called plaimos consists wearable sensors fixed measurement station network infrastructure employs ieee ieee transmit data security mechanisms server analyze information collected apps ios android windows mobile operating systems provide real time measurements developed architecture designed primarily record report electrocardiogram heart rate data also monitors parameters associated chronic respiratory illnesses including patient blood oxygen saturation respiration rate body temperature fall detection galvanic resistance
underactuated robotic hands becoming popular complex robotic designs mass size yet limited designs require tradeoff versatility simplicity case prosthetic robotic hands need imitate human hand functionality dimensions closely possible achieve natural feeling solution patient paper presents initial mechanical analysis design anthropomorphic hand degrees freedom using six electric motor actuators transmission system cables pulleys used underactuated mechanism order propagate motor torque three joints finger springs used provide passive return actuation design validated according ability stably grasp different cylindrical objects stability grasp judged according criterion positive zero contact forces present points contact hand object static case simulation grasping procedure contact forces aremodeled time developed matlab shown design process requires iterative steps multiple factors spring stiffness pulley radii motor torques affect stability grasping hand effectiveness prosthetic device
paper uses artificial intelligent algorithms reconfiguration distribution network problem formulated optimization problem objective function minimized power losses constraints nodal voltage magnitude limits branch current limits kirchhoff current law kcl kirchhoff voltage law kvl network radiality condition state tie switch considered control independent variable nodal voltage magnitude branch current considered state dependent variables state variables continuous whilst switch state integer binary variable problem mixed integer programming one state switch closed open binary particle swarm optimization bpso neural network used separately solve problem effectiveness proposed method demonstrated example
objectivesto examine month change life space mobility predictor subsequent month mortality community dwelling older adults designprospective cohort study settingcommunity dwelling older adults five alabama counties university alabama birmingham uab study aging participantsa random sample medicare beneficiaries stratified according sex race rural urban residence recruited november february followed telephone interview every months subsequent years measurementsmortality data determined informant contacts confirmed using national death index social security death index life space measured interview using uab life space assessment validated instrument assessing community mobility eleven thousand eight hundred seventeen month life space change scores calculated years follow generalized linear mixed models used test predictors mortality subsequent month intervals resultsthree hundred fifty four deaths occurred within months two sequential life space assessments controlling age sex race rural urban residence comorbidity life space score life space decline preceding month interval predicted mortality point decrease life space resulted increase odds dying subsequent months odds ratio conclusionslife space score beginning month interval change life space months associated significant differences subsequent month mortality life space assessment may assist clinicians identifying older adults risk short term mortality
electric motors account electricity consumption korean manufacturing sector represents total electric power demand korea efficient use motors manufacturing sector therefore essential controlling electric power demand korea study analyzes potential economic feasibility reducing electric motor electricity consumption korean manufacturing sector presently korea enforces minimum energy performance standards meps three phase induction electric motors rated less industrial electricity price much lower organization economic operation development oecd average addition load factors electric motors generally far optimal efficiency variable speed drive vsd installation rates lower advanced countries study analyzes amount cost reducing electricity consumption following scenarios modeled additional strategies current meps reducing energy consumption expansion meps enforcement increasing industrial electricity price enhancement motor load factors installation vsds study found increasing industrial electricity price largest electricity reduction potential economically beneficial society
study investigate effects paeoniflorin renal function cyclophosphamideinduced mice mice injected intraperitoneal cyclophosphamide cyp saline respectively mice treated day vehicle next days mice sacrificed analyze biochemical histological parameters mechanism research results shown significantly decreased urine levels uric acid creatinine serum kidney levels cytokines interleukin interleukin beta beta tumor necrosis factor alpha tnf alpha also obviously attenuated histological changes kidney tissues caused cyp moreover western blot demonstrated increased ampk levels inhibited kappa signaling pathway apoptosis cyp stimulated kidney tissues conclusion might considered effective agent amelioration kidney toxicity resulting cyp treatment published elsevier masson sas
purpose review pain one common feared symptoms associated new diagnosis cancer subsequent treatment unfortunately remains undertreated around one third patients recently postulated one mechanism could failure recognize neuropathic pain one attractive option case neuropathic pain pain associated intolerable side effects prescribed opioids use topiceuticals means targeted pain relief potentially fewer side effects present review summarizes evidence base various topiceuticals available treatment localized neuropathic pain recent findings recent evidence base established treatments capsaicin lignocaine examined variety novel previously used therapies considered summary use topiceuticals localized neuropathic pain associated malignancy remain valuable option many advantages systemic treatments addition anecdotal reports efficacy growing body evidence consider early use topical lignocaine capsaicin context authors proposed guideline including use topiceuticals aid management neuropathic pain
hybridcheck software package visualize recombination signal large dna sequence data set used analyse recombination genetic introgression hybridization horizontal gene transfer scan large multiple contigs whole genome sequences three individuals hybridcheck written software linux windows operating systems simple graphical user interface addition code readily incorporated scripts analysis pipelines hybridcheck implements several abba baba tests visualizes effects hybridization resulting mosaic like genome structure high density graphics package also reports following breakpoint positions number mutations introgressed block iii probability identified region caused recombination estimated age recombination event divergence times donor recombinant sequence calculated using hky gtr correction dating algorithm exceedingly fast estimating coalescence time introgressed blocks possible distinguish hybridization incomplete lineage sorting hybridcheck libre software manual free download
objective polymorphisms glucocorticoid receptor gene associated outcome corticosteroid responsiveness among patients inflammatory disorders conducted candidate gene association study test hypothesis polymorphisms associated outcome corticosteroid responsiveness among children septic shock design genotyped children septic shock presence two glucocorticoid receptor polymorphisms associated increased sensitivity one glucocorticoid receptor polymorphism associated decreased sensitivity corticosteroids primary outcome variable complicated course defined day mortality persistence two organ failures days septic shock diagnosis used logistic regression test association corticosteroid exposure outcome within genotype group adjusted illness severity setting multiple picus united states interventions standard care measurements main results differences outcome comparing various genotype groups among patients homozygous wild type glucocorticoid receptor allele corticosteroids independently associated increased odds complicated course odds ratio conclusions based glucocorticoid receptor polymorphisms could detect beneficial effect corticosteroids among genotype group among children homozygous wild type allele corticosteroids independently associated increased odds poor outcome
objectives assess american newspaper coverage regarding racial ethnic minority health disparities mhds methods lexisnexis queried specific word combinations elicit mhd articles printed newspapers full texts read articles categorized racial ethnic group specific mhd topics mentioned results five years mhd articles published representing articles health newspapers gave much attention mhd discussed conferences meetings speeches senior health officials politicians cancer cardiovascular disease hiv aids frequent among disease specific mentions articles african americans comprised race ethnicity mentioning articles conclusions despite release major organizational reports publication many studies confirming prevalence mhd newspaper articles published explaining mhd public general public low rate health literacy health world collaborate media present consistent simple message concerning gaps care experienced racial ethnic minority groups time consumer directed healthcare americans understand mhds exist may galvanize advocate disparity elimination quality improvement
nonalcoholic fatty liver disease nafld common cause hepatic steatosis patients inflammatory bowel disease ibd metabolic syndrome mets intestinal inflammation implicated nafld pathogenesis performed retrospective cohort study patients ibd nafld seen health system january december examine associations ibd severity phenotype mets nafld fibrosis estimated nafld fibrosis score nfs total patients included analysis patients mets ibd patients mets significantly older time ibd diagnosis nafld diagnosis ibd patients mets higher alt ast comparing mets patients non mets ibd patients significant difference ibd medication use steroids anti tnfs immunomodulators nafld medication use statins patients concomitant mets significantly higher nfs scores non mets patients ibd disease severity disease location ibd medication use associated nafld severity knowledge first study demonstrate nafld severity ibd patients associated presence mets severity ibd
gene expression profiling philadelphia negative chronic myeloproliferative neoplasms mpns unraveled significant deregulation several immune inflammation genes potential importance clonal evolution mechanisms might downregulation major histocompatibility class genes used tumor cells escape antitumor cell mediated immune responses several genes encoding human leukocyte antigen hla class molecules shown significantly downregulated upregulation hla genes considered one mechanisms action interferon ifn alpha regulation genes ifn alpha treatment mpns never studied findings show significant upregulation several hla genes importance tumor immune surveillance ifn alpha treatment mpns mechanism might enhance cytotoxic potential immune cells mpns explain induction minimal residual disease ifn alpha treatment patients
enzyme linked immunosorbent assay elisa technique based specific recognition ability molecular structure antigen epitope antibody likely important diagnostic technique used today bioscience methodology possible diagnose illness allergies alimentary fraud even detect small molecules toxins pesticides heavy metals etc reason procedures improve detection limit sensitivity reduce analysis time could important impact several fields respect many methods developed improving technique ranging fluorescence substrates methods increasing number enzyme molecules involved detection biotin streptavidin method context nanotechnology offered significant number proposed solutions mainly based functionalization nanoparticles gold carbon could used antibody carriers well reporter enzymes like peroxidase however works focused study best practices nanoparticle functionalization elisa enhancement work use gold nanoparticles aunps vehicle secondary antibodies peroxidase hrp design experiments technique doe four different methods biomolecule loading compared using rabbit igg goat anti rabbit igg elisa model adsorption directional covalent combination thereof result aunp probes prepared direct adsorption effective method aunps probes used detect gliadin one main components wheat gluten protein composite causes celiac disease optimized approach data showed sensitivity increase least five times lower detection limit respect standard elisa least three times additionally assay time remarkably decreased
background study analyzes effects physical exercise urinary collagen crosslinks pyridinoline pyd deoxipyridinoline dpd women methods thirty premenopausal pre postmenopausal pst women took part six month randomized controlled trial moderate physical exercise moreover skinfold thickness muscle strength flexibility evaluated results basal values urinary pyd dpd higher postmenopausal women versus premenopausal women physical exercise increased groups urinary pyd levels urinary dpd levels postmenopausal women exercise program changes observed levels urinary dpd premenopausal women significant improvements flexibility muscle strength decrease skinfolds thickness observed exercise group changes observed non exercise group conclusions conclusion physical activity program produced beneficial effects muscle strength flexibility changes musculoskeletal system also physical activity program led non pathological increase urinary elimination bone reabsorption collagen metabolism biomarkers
icatibant used treat acute hereditary angioedema inhibitor deficiency types inh hae types shown promise angioedema due acquired inhibitor deficiency inh aae data icatibant outcome survey ios analysed evaluate effectiveness icatibant treatment patients inh aae compare disease characteristics inh hae types key medical history including prior occurrence attacks recorded upon ios enrolment thereafter data recorded retrospectively approximately month intervals patient follow visits icatibant treated population patients inh aae attacks patients inh hae types attacks patients inh aae versus inh hae types often male versus significantly later mean confidence interval age symptom onset versus years time symptom onset diagnosis significantly shorter patients inh aae versus inh hae types mean months versus months patients inh aae showed trend higher occurrence attacks involving face versus attacks overall angioedema attacks severe patients inh hae types versus inh aae versus attacks classified severe severe median total attack duration patients inh aae versus inh hae types respectively
blood constituent examination important means health diagnosis blood constituent examination usually adopt method drawing blood bring pain risk cross infection patient near infrared spectrum spectroscopy nirs research hotspot noninvasive blood constituent examination spectral data acquisition system existing instruments using single chip microcomputer scm microcontroller spectral data acquisition system realize high speed multi channel acquisition storage large amounts data scm certain deficiency high speed multi channel spectral data acquisition system based field programmable gate array fpga designed paper order realize system high speed multi channel high signal noise ratio snr area noninvasive blood constituent examination near infrared spectroscopy altera cyclone series fpga used microcontroller spectral data acquisition system simultaneously controlled two pieces eight channels conversion chip acquiring channels blood pulse wave signal parallel control fpga data cached fpga internal ping pong rani first transferred sram chip finally sent computer via usb port experiment result shows spectral data acquisition system collect channels signal parallel fast sampling frequency repetitive signal noise ratio system collect spectrograms per second get high snr human body blood pulse wave signal circumstances spectral data acquisition system satisfies basic requirements noninvasive blood constituent examination instrument nirs make instrument collect human body blood pulse wave data high speed main innovation point article applying fpga spectral data acquisition system near infrared noninvasive blood constituent examination instrument fpga able simultaneously control two pieces eight channels conversion chip acquiring channels blood pulse wave signal parallel using fpga microcontroller spectral data acquisition system solve problem scm microcontroller realize multi channel high speed data acquisition storage large amounts data acquisition speed greatly faster system second innovation point article use fpga internal resources establish ping pong rani buffer spectral data chip bit however sram chip bit data bus via ping pang ram buffer spectral data transfer chip sram chip ping pong ram realize different digits data seamless transfer chip sram chip
objective describe epidemiology injuries sochi winter paralympic games methods total athletes countries monitored daily days sochi winter paralympic games athlete days daily injury data obtained teams medical support teams athletes teams without medical support teams athletes electronic data capturing systems results total injuries reported injury incidence rate per athlete days significantly higher recorded alpine skiing snowboarding compared cross country skiing biathlon ice sledge hockey wheelchair curling injuries shoulder region highest single joint although total upper lower body similar furthermore acute injuries significantly higher types injury onset conclusions winter paralympic games setting athletes report higher injury incidence olympic athletes athletes summer paralympic games setting highest incidence injury reported alpine skiing snowboarding sporting category similar incidence injury upper lower limbs joint greatest rate injury reported shoulder joint data inform injury prevention programmes policy considerations regarding athlete safety future winter paralympic games
ability derive functional thyroid follicular cells embryonic stem cells escs induced pluripotent stem cells ipscs would provide potential therapeutic benefit patients congenital post surgical hypothyroidism furthermore understanding process thyroid follicular cells develop also provide great insight key steps regulate development tissues derived endoderm review advances understanding process thyroid follicular cell development including creation two models allowed rescue hypothyroid mouse recipients transplantation thyroid follicular cells derived mouse escs rapid progress field suggests success achievable human escs ipscs near future additionally availability esc ipsc derived thyroid follicular cell models provide ideal systems explore genetic mutations drugs illness impact thyroid function cell autonomous fashion elsevier ireland ltd rights reserved
resources scarcity electricity demand dramatically increasing wastewater recognized one resources water energy plant fertilizing nutrients nevertheless current wastewater treatment technologies limitations due principally energy cost intensive achieving conversion target wastewater recovery desired develop new technology generate alternatives conventional energy sources sustainable manner innovative technology based use microbial fuel cells mfcs proved critical pathway bioconversion processes towards electricity generation addressing energy environmental problems three special features including energy saving less sludge production less energy production make mfcs outstanding compared existing technologies multiform wastewaters could efficiently degraded advancing mfcs alone integrating mfcs processing units however low power density high operating cost mfcs greatly limited applications large scale problems result debates doubts development applications therefore paper objectively discussed problems applications mfcs wastewater treatment moreover integration mfcs treatment processes presented verify practicality effectiveness mfcs contaminants removal furthermore primary challenges opportunities scaling future applications mfcs wastewater analyzed
competition collaboration two universal ingredients human cultures competition observed time phenomenon helped people achieve best potentials various fields competition also helped individuals achieve feats would ordinarily achieved pushed beyond limits also said cooperation collaboration used achieve specific goals objectives hence competition collaboration vital creating healthy learning process among students paper discusses competitive collaborative platform learning process two selected online courses electrical engineering using platform developed labview programming language community students encouraged compete online try reduce block diagrams subsystems control engineering well reduce given series parallel resistor circuits shortest time amount steps possible end trial students view finish time students share online individual solutions community well discuss ideas reduction techniques find expedient via public online notepad creates means learning community platform helps passively induce competitive collaborative perspective learning pathway students thereby improving interest experience students selected subject areas platform uses online server maintain communications students various locations students view timed performance counterparts leadership board thereby engendering induced competition learning community instructor administrator also monitor activities community server portal
purpose examine association overactive bladder symptom score oabss neuropsychological parameters moreover investigate factors affect item questionnaire materials methods total patients males females probable alzheimer disease recruited cognitive testing conducted using mini mental status examination mmse clinical dementia rating cdr scale global deterioration scale gds barthel activities daily living adl lower urinary tract symptom luts assessed using oabss voiding diary results prevalence overactive bladder oab defined oabss urgency score patients among oab subjects common severity symptom moderate followed mild severe found oabss high correlation aging compared neuropsychological parameters found oabss highly correlated cdr scores however significant correlation found changes oabss scores neuropsychological parameters based individual symptom scores urgency incontinence highly correlated cdr scores conclusions oabss useful tool assessing patients luts consistent positive association oabss severity including urgency incontinence cdr scores
using navier stokes equation assuming viscosity radially modulated quasi newtonian fluid obtain impedance fluid microchannels corresponding electrical analogs solve navier stokes equation use laplace transform bromwich integral residue theorem bessel functions give formula impedance terms bessel functions equations constructed equivalent electrical circuits solutions correspond case quasi newtonian fluid say fluid stagnate channel wall case fluid newtonian formulas obtained may applications general theory microfluidics microscopic systems design drug delivery
task allocation problems traditionally focused cost optimization however attention given cases cost always sole major consideration paper study fair task allocation problem transportation optimal allocation low cost importantly distributes tasks even possible among heterogeneous participants different capacities costs execute tasks tackle fair minimum cost allocation problem analyze solve two parts using two novel polynomial time algorithms show despite new fairness criterion proposed algorithms solve fair minimum cost allocation problem optimally polynomial time addition conduct extensive set experiments investigate trade cost minimization fairness experimental results demonstrate benefit factoring fairness task allocation among majority test instances fairness comes small price terms cost elsevier ltd rights reserved
facial hair like many masculine secondary sexual traits plays significant role perceptions array sociosexual traits men consensus beards enhance perceptions masculinity age social dominance aggressiveness perceived attractiveness facial hair varies greatly across women given ease facial hair groomed removed entirely men retain beards others choose remove hypothesized men relatively sexist attitudes would likely allow facial hair grow men less sexist attitudes men usa india completed online survey measuring demographic variables ambivalent sexism facial hair status controlling demographic variables men facial hair significantly higher hostile sexism clean shaven men hostile sexism significant predictor facial hair status demographic variables facial hair frequent among ambivalent hostile sexists among benevolent non sexists suggested sexist men choose grow facial hair maximizes sexual dimorphism augments perceived masculinity dominance
present study investigates deviatoric response dense particle suspensions consisting silicon carbide suspended ethylene glycol using piezoresistive stress gages means experimentally measuring dynamic strength materials validity method first shown pure liquid environment recovering hydrodynamic behavior liquid deviatoric response dense suspension indicative shock induced stiffening within mixture whereby stress state largely influenced suspended particles mesh free numerical approach smoothed particle hydrodynamics used investigate shock induced mesostructural deformation suspension measured deviatoric response suspensions discussed terms formation inter particle contact networks force chains result shock induced mesostructural changes suspensions
defending return oriented programing rop attacks extremely challenging modem operating systems popular mobile running arm android even vulnerable rop attacks due weak implementation aslr absence effective control flow integrity enforcement paper leveraging specific arm features instruction randomization strategy mitigate rop attacks android even threat single pointer leakage vulnerabilities proposed popping registers functions epilogue instructions reallocating registers function scopes branch targets direct indirect branch instructions potential rop gadgets changed randomly without knowledge binaries runtime instructions layout adversary repeated control flow transfer rop exploits subverted furthermore instruction randomization idea implemented android dalvik runtime art corresponding evaluations proved capable introduce enough randomness discovered functions thwart rop gadgets application shared libraries oat file compiled dalvik bytecode besides evaluations real world exploits also confirmed effectiveness mitigating rop attacks within acceptable performance overhead
informal groups form hierarchies allocate social status order coordinate action make collective decisions although researchers identified characteristics people tend get status extent characteristics context dependent unclear two studies participants united states germany engaged affiliative competitive group interactions investigated whether nature group task moderated relationship status attainment personality previous research found extraversion predicted status competitive affiliative contexts contrast agreeableness associated status affiliative contexts findings underscore importance examining relationship personality social status context
generativity contributing next generation important well throughout middle late life therefore crucial understand contributes generativity life stages parenting work common ways people engage generatively prosocial behavior another community connection may encourage generative contributions adults however older adults may face obstacles generative may need additional drive engage behaviors given expected community cohesion would predict prosocial behavior despite age grit would provide motivation older adults current study examined whether age moderated relation grit prosocial behavior data used upper midwest adults aged multiple regression analyses showed age moderated relation grit prosocial behavior grit predicted prosocial behavior older adults middle age adults sense community cohesion predictive prosocial behavior despite age grit may promote generative acts different ways depending age sense community cohesion may foster community contributions despite age discussion focuses future directions ways promote generativity using research elsevier ltd rights reserved
mathematical modelling theoretically established tool developing solar heating systems using transfer functions know transfer functions system outlet temperature predicted function input variables solar irradiance inlet temperature environment temperatures dynamic analysis carried stable system control effectively designed based well tried methods control engineering purposes new validated transfer functions solar heating systems worked study based mathematical model found literature applied successfully field transfer functions used dynamic analysis control design solar heating systems dynamic analysis presented efficiency proposed stable control demonstrated respect real solar heating system elsevier ltd rights reserved
age associated alterations cardiovascular structure function induce cardiovascular disease elderly subjects investigate effects normal vascular aging nva early vascular aging eva hemodynamic characteristics circle willis cow closed loop one dimensional computational model developed based fluid mechanics vascular system numerical simulations revealed higher central pulse pressure augmentation index aix appear eva subjects due early arrival reflected waves resulted increase cardiac afterload compared nva subjects moreover hemodynamic characteristics cow show eva subjects older age display higher blood pressure nva complete cow herein increased blood pressure flow rate coexist subjects incomplete cow conclusion hemodynamic characteristics aortic tree cow related aging appear play important role causing cardiovascular intravascular disease
increasing fuel costs regulation emissions encouraging operators shipbuilders researchers seek improvements marine vessel efficiency area vessel electrical systems increasing choices result research development past decade giving rise number promising new technologies promising new battery chemistries developed existing chemistries enhanced nano technology supercapacitors fuel cells powering ferries permanent magnets enabling novel motor topologies solar panel prices decreasing addition new technologies recently commercialised vessels new developments electric vehicles grid electrical systems applicable marine environment article reviews emerging electrical technologies focusses potential improving vessel efficiency within next decade
faculty engineering king abdulaziz university plans redesign undergraduate courses required students different programs courses annual enrolment students year operations research teaching area department industrial engineering presented case study area involves two core three elective courses course redesign involves preparing students fundamentals engineering exam requirements coping best worldwide practices benchmark exam computer based test cbt closed book electronic reference examinees hours complete exam contains multiple choice questions hour time also includes tutorial optional scheduled break exam session administered following seven disciplines chemical civil electrical computer environmental industrial systems mechanical disciplines top ten usa universities industrial manufacturing engineering used benchmark reliably lead desired courses redesign results moreover faculty experience also utilized enhance process
based application guidance enterprise internal control engineering project paper takes listed companies construction industry research samples unscrambled development rules internal control quality construction enterprises two aspects self evaluation verification goal achievement analyzed impact internal control quality corporate value study finds internal control quality companies concerned improving especially internal control quality engineering projects significant positive correlation companies sustainability current market value study would provide support serve references future efforts strengthen establishment internal control quality upgrade corporate value
aim role uric acid risk factor cardio cerebrovascular diseases controversial study aimed investigate relationship serum uric acid level risk cardio cerebrovascular events middle aged non obese chinese men methods included participants health examination center tongji hospital june june clinical examination medical records collected annual health examination hazard ratios hrs uric acid cardio cerebrovascular events calculated cox proportional hazards models generalized additive model threshold effect analysis used explore non linear relationship serum uric acid level incidence cardio cerebrovascular event result mean follow time months participants classified four groups serum acid quarter hrs cardio cerebrovascular events respectively compared reference actual incidence conditional incidence cardio cerebrovascular events high serum acid group higher low serum acid group stratified turning point sua mol also showed strong prognostic accuracy multiple variable based score years years area receiver operating characteristic roc curve respectively conclusion serum uric acid level strong risk factor cardio cerebrovascular events
objectives present study examined factors associated emergence cessation youth cyberbullying victimization taiwan methods total students high schools assessed grade follow performed grade self administered questionnaires collected multiple logistic regression conducted examine factors results multivariate analysis results indicated higher levels risk factors online game use exposure violence media internet risk behaviors cyber school bullying experiences grade coupled increase risk factors grades could used predict emergence cyberbullying perpetration victimization contrast lower levels risk factors grade higher levels protective factors coupled decrease risk factors predicted cessation cyberbullying perpetration victimization conclusion online game use exposure violence media internet risk behaviors cyber school bullying experiences used predict emergence cessation youth cyberbullying perpetration victimization
report patient developing postoperative peritoneal infection aspergillus fumigatus galactomannan serum levels negative throughout time course galactomannan levels peritoneal fluids yielded high results serological testing peritoneal fluids fungal antigens might useful easily applicable tool support diagnosis intraabdominal aspergillosis represents rare type invasive fungal infection
paper introduces kind rectifier circuit adjustable constant current charging circuit detecting voltage circuit display circuit power circuit six parts constant current source charger design scheme charger using amp composition adjustable constant current charge constant current source circuit avoid constant voltage charging lack output voltage vary load using timer consists oscillator general fet dual operational amplifier compared voltage reference test voltage circuit realize full automatic disconnection functions
paper homotopy perturbation method hpm variational iteration method vim used solve large amplitude torsional oscillations equations nonlinearly suspension bridge paper compares hpm vim order solve equations nonlinearly suspension bridge comparative study hpm vim presented work achieved results reveal hpm vim effective convenient quite accurate nonlinear partial differential equations methods easily extended strongly nonlinear oscillations found widely applicable engineering science laplace transform method applied obtaining lagrange multiplier vim solution
background aim takayasu arteritis occasionally complicated inflammatory bowel disease ibd study assessed endoscopic genetic features ibd complicated ibd methods study retrospectively reviewed clinical charts patients men women median age years range years human lymphocyte antigen hla types single nucleotide polymorphism ilb gene assessed patients respectively results inflammatory bowel disease diagnosed patients endoscopic features ibd initial diagnosis showed discontinuous focal mucosal inflammations one case diagnosed ulcerative colitis first colonoscopy genetic comparison hla class patients ibd without ibd hla frequent ibd group respectively meanwhile hla drb dqa dqb dpb hla class positively associated ibd respectively ilb show association ibd compared without ibd conclusions endoscopic findings ibd initial diagnosis atypical crohn disease ibd possessed hla haplotype susceptible effect
objectives research lacking emotional effects families serious chronic illness infants examined effect diagnosis serious liver disease infants upon parent psychological symptoms family functioning hypothesized parent psychological symptoms family functioning father engagement predict infant emotional outcomes methods parents infants recently diagnosed serious liver disease completed validated questionnaires parent stress family function impact illness family father engagement measures repeated year addition child behavior checklist cbcl results parents infants participated parent stress family functioning scores elevated parent psychological symptoms family function father engagement predict infant outcome mothers infant diagnosis biliary atresia number outpatient visits impact illness family explained variation cbcl fathers socioeconomic status infant diagnosis biliary atresia whether infant transplant impact illness family explained variation cbcl conclusions parents families appear resilient coping serious infant illness infant diagnosis biliary atresia parental perceptions high impact illness family indicators negative emotional outcomes infants serious liver disease psychosocial interventions infants chronic illness target reducing impact illness family
aim study examine effectiveness enzyme treated asparagus extract etas improving stress response randomized double blind placebo controlled cross trial undertaken healthy volunteers etas placebo consumed washout period psychological parameters examined using self report scale questionnaire psychological stress applied using uchida kraepelin test stress load autonomic nervous function analyzed stress load profile mood states poms psychological rating performed serum cortisol plasma catecholamine salivary secretory immunoglobulin siga salivary cortisol analyzed etas intake improved self reported rating items feel tired hard get feel heavy psychological questionnaire ameliorated self reported rating items depression dejection fatigue poms questionnaire increased salivary siga levels test contrast serum salivary cortisol levels plasma catecholamine change test etas significantly upregulated sympathetic nerve activity furthermore etas intake significantly increased number answers number correct answers test suggesting might improve office work performance swiftness accuracy stressful conditions conclusion etas supplementation reduced feelings dysphoria fatigue ameliorated quality sleep enhanced stress load performance well promoted stress response increasing salivary siga levels data suggest etas intake may exert beneficial effects resulting well controlled stress management healthy individuals
get vote mailers using explicit social pressure consistently increase electoral turnout however often generate negative reaction backlash one approach increase turnout yet alleviate backlash may use implicit social pressure implicit social pressure technique shown promise display set eyes researchers contend eyes generate feeling watched cues subjects act prosocial ways demonstrate compliance social norms several studies support argument including two voter mobilization studies technique widely tested however political context five randomized field experiments test impact turnout mobilization mailers using eye displays extend previous research testing differences effects male female eyes across political cultures effects substantively statistically weak best inconsistent previous findings
injured body parts artistic gymnastics lower extremities ankle sprains purpose study investigate young artistic gymnasts risk factors ankle injuries two year period two hundred artistic gymnasts aged years compete recruits group participated study results showed landing take phases greater frequency injuries constitute factor danger likely appearance ankle injuries majority ankle injuries observed dismounts floor exercises duration daily training considerable repetition jumps constituted risk factors ligament sprains ankle landing common injuries usually occur exercises back rotation particularly back somersaults number take offs elements daily vault affect appearance ankle injuries common injuries achilles tendinitis occur front rotation exercises conclusively young gymnasts experience great number ankle injuries especially dismounts prevent injuries restrict pressure lower extremities must use supplementary soft pits mats training landing phase
study examined direct indirect pathways maternal effortful control aspects children self regulation executive functioning behavioral regulation via maternal emotional support two hundred seventy eight children primary caregivers mothers participated laboratory visits children years teachers reported children behavior kindergarten year assessment maternal effortful control measured using adult temperament questionnaire evans rothbart maternal emotional support observed semistructured mother child problem solving task year assessment children executive functioning measured using laboratory tasks designed assess updating working memory inhibitory control cognitive flexibility whereas behavioral regulation assessed via teacher report questionnaires children attention control discipline persistence work habits results structural equation modeling indicated controlling child gender minority status maternal education maternal effortful control indirectly associated child executive functioning behavioral regulation maternal emotional support maternal effortful control direct association children teacher reported behavioral regulation observed executive functioning findings suggest maternal effortful control may key contributing factor development children self regulatory competencies impact maternal emotional support
code pncmc program natural circulation motion conditions developed natural circulation simulation marine reactors code based one dimensional two fluid model noninertial frame reference body force term momentum equation considered time dependent function consists gravity inertial force induced three dimensional ship motion staggered mesh finite volume method semi implicit first order upwind scheme successive relaxation sor method used discretize solve two phase mass momentum energy equations single phase natural circulation experiments rolling condition performed institute nuclear new energy technology tsinghua university two phase natural circulation experiments rolling condition performed tan colleagues used validate pncmc validation results indicate pncmc capable investigate single phase two phase natural circulation rolling motion
purpose review purpose study provide overview clinical applications pet setting cardiac imaging emphasis specific scenarios techniques together provided added information recent findings synergy cardiac pet fusion may hold similar promise eliminating ionizing radiation improving tissue contrast future development new hybrid scanners use new imaging tracers clinical applications significant factors influence use summary positron emission tomography pet cardiac magnetic resonance imaging cmr provide important anatomic physiologic information regard heart able combine data two examinations hybrid technique allows complete evaluation cardiac pathology hybrid pet already established utility combined imaging approach use cmr lieu allows elimination ionizing radiation improved tissue contrast
concept mapping takes values infinite dimensional functional space studied mathematical community since third decade last century effort produced range important contributions many already made way applied sciences successfully used facilitate numerous practical applications across various fields surprisingly enough one particular field could benefited contributions much greater extent still relies finite dimensional models approximations thus missing numerous advantages offered adopting general framework field image processing focus study particular paper introduce alternative approach analysis multidimensional imagery data based mathematical theory function valued mappings addition extending various tools standard functional calculus generalize notions fourier fractal transforms followed application processing multispectral imaging data applications future extensions work discussed well
susceptibility thick high density polyethylene geomembrane brittle rupture long term stress cracking simulated municipal solid waste landfill liner examined geomembrane pre aged leachate degrees lower notched constant tensile load stress crack resistance geomembrane aged geomembrane used part composite liner system geosynthetic liner longevity simulators gllss geosynthetic clay liner sand foundation layer geomembrane geotextile protection layer drainage gravel geomembrane gllss allow simulation field conditions including elevated temperatures overburden pressure leachate circulation composite liner exposure conditions geomembrane experienced brittle rupture side slopes local gravel indentations temperatures degrees higher liner temperature shorter time rupture higher tensile strain rupture arrhenius modelling test data gave activation energy mol
background health risk behaviours prominent late adolescence young adulthood yet population level research examining relationship drug alcohol use sexual health behaviour among young people scarce despite public health calls integrated approach health improvement objective understanding scale nature relationship using contemporary data britain third national survey sexual attitudes lifestyles natsal methods analyses data natsal stratified probability survey men women aged years undertaken using computer assisted personal interviewing carried logistic regression used explore associations reporting frequent binge drinking weekly recent drug use within past weeks multiple types substance use key sexual risk behaviours adverse sexual health outcomes examined sociodemographic profile health behaviours attitudes reported risky young people defined reporting type substance use plus non condom use first sex new partner last year results men women reporting frequent binge drinking recent drug use likely report unprotected first sex new partner last year first sex last partner recently meeting emergency contraception use last year sexually transmitted infection diagnosis past years associations sexual risk frequently stronger reporting multiple substance use particularly among men profile risky young people differed years old conclusions nationally representative study substance use strongly associated sexual risk adverse sexual health outcomes among young people qualitative event level research needed examine context motivations behind associations inform joined interventions address inter related behaviours
distributed maximum power point tracking mppt photovoltaic systems drawn increased attention since inhomogeneous irradiance modules significantly deteriorate effectiveness solar energy harvest address issue paper focuses developing highly efficient submodule integrated converter submic connected across submodule panel gallium nitride gan field effect transistors utilized synchronous buck converter topology achieve high conversion efficiency reduced size converter prototype digitally controlled using microcontroller mppt developed tested considering various irradiation conditions peak efficiency proposed gan based submic measured higher khz switching frequency whereas accuracy mppt considering low power conditions
increased inflammation arising abnormal immune response damage healthy tissue lead disease progression important example accumulation inflammatory mediators kidney subsequently lead hypertension renal injury origin inflammation may involve neuro immune interactions example novel vagus nerve spleen mechanism known cholinergic anti inflammatory pathway controls inflammation upon stimulation however pathway dysfunctional inflammation becomes less regulated chronic inflammatory diseases hypertension may develop systemic lupus erythematosus sle autoimmune disease aberrant immune function increased renal inflammation prevalent hypertension hypothesized cholinergic anti inflammatory pathway impaired sle stimulation pathway would protect progression hypertension sle mice female sle nzbwf control nzw mice administered nicotine vehicle days day subcutaneously order stimulate cholinergic anti inflammatory pathway level splenic nicotinic acetylcholine receptor nachr blood pressure assessed posttreatment nicotine treated sle mice develop hypertension lower blood pressure compared saline treated sle mice coincided lower splenic renal cortical expression pro inflammatory cytokines data provide evidence cholinergic anti inflammatory pathway impaired sle addition data suggest stimulation cholinergic anti inflammatory pathway protect kidney dampening inflammation therefore prevent progression hypertension setting sle
objectives hypotheses systematic review following prevalence post traumatic stress disorder ptsd differ various types chronic pain consistent evidence associated ptsd methods studies fulfilled inclusion exclusion criteria review grouped according type reported prevalence ptsd grouping determined aggregating patients studies group additionally patients groupings combined percentage studies found association ptsd determined consistency evidence represented percentage studies finding association rated according agency health care policy research guidelines results grouping ptsd prevalence differed ranging low chronic low back pain high veterans prevalence general population studies found association ptsd generating consistency rating consistent multiple studies three groupings generally consistent rating veterans grouping received finding inconsistent rating conclusion results systematic review confirmed hypotheses review
mega urbanization presents researchers network densely interwoven problems completely elude disciplinary boundaries report development spatial knowledge management agent simulation framework designed integrate closely process trans disciplinary research dynamics complex human environment systems argue choice knowledge representation languages facilitates cross domain collaboration direct involvement domain experts without prior experience computer programming run application example show standardized knowledge engineering technologies used turn conventional geodatabase self documenting knowledge base flexibly interface modern open data infrastructures resulting cross domain world model coupled graphical actor modeling language specializes formulation behavioral theories terms social roles intentions tasks conditions interaction finally describe system theories expressed way automatically translated computer simulations elsevier ltd rights reserved
alternative complementary procedures adopted preparing arylazetidine derivatives moderate good yields preliminary biological evaluation arylazetidines ligands nicotinic acetylcholine receptors allowed identify chloro substituted analogs interesting congeners title compounds may considered suitable hit compounds developing new nicotinic acetylcholine receptor ligands may safer currently available drugs targeting nicotinic acetylcholine receptors described synthetic approaches enable facile access large number diversely decorated azetidines studying structure activity relationships refining toxico pharmacological profile agents
primary concern psychology religion distinct possibility responses empirical assessments individuals degree type religiosity spirituality exaggerated owing social desirability bias spite increased secularization american culture growing distrust organized religion religious involvement personal religiosity spirituality still viewed highly desirable characteristics study estimates extent social desirability biases affect self reports religion spirituality utilizing bogus pipeline procedure procedure participants convinced experimenters detect disingenuous responses individual items questionnaires use physiological measures although physiological data actually collected self reports participants bogus pipeline condition indicate greater religiosity spirituality control condition self report bias indicated bogus pipeline procedure used areas study increase veracity self reports social desirability effects present reporting sexual behaviors prejudice results indicate social desirability biases influence multiple constructs including religious orientations religious coping daily spiritual experiences implications future research relying self reports religion spirituality discussed
background self injury institutional violence well known characteristics female forensic psychiatric patients research patients experiences behaviours limited aim aim study investigate female forensic psychiatric patients describe self injury aggression methods authors performed qualitative depth interviews female forensic psychiatric inpatients interviews analysed using thematic analysis results analysis resulted three themes describing process handling negative thoughts emotions using self injury aggression towards others thereby experiencing satisfaction self injury aggression experienced strategies emotional regulation forensic psychiatric care perceived important women developing less harmful strategies coping negative thoughts emotions instead injuring others conclusions self injury aggression often risk assessed separately results present study suggest behaviours need holistic approach
study describes conceptual design first prototype implementation multi sense cardiopatch wearable multi sensor patch remote heart monitoring aimed providing detailed comprehensive heart status diagnostics system integrates multiple sensors single patch detection electrical electrocardiogram ecg mechanical heart sounds cardiac activity addition physical activity prototypal system also comprises microcontroller board radio communication unit powered ion rechargeable battery results preliminary evaluations healthy subjects shown prototype successfully measure electromechanical cardiac activity providing useful cardiac indexes system potential improve remote monitoring cardiac function chronically diseased patients undergoing home based cardiac rehabilitation programs
present investigation examined three salient features narrative thinking situation model construction linguistic concreteness perspective taking influenced social inference process results four experiments indicated compared given objectives perceivers given narrative objectives likely make situation rather trait attributions observed behaviors experiment less likely make implicit trait inferences experiment less likely rely behavior valence making evaluative judgments experiment linguistic analyses indicated narrative construction consistently entailed creation situation models events linguistic concreteness situation model creation mediated relationship narrative inferences experiment confirmed mediating role situation models perceivers narrative objectives made trait inferences behaviors inconsistent contextual information role core narrative features social perceptions discussed
representational state transfer rest web services gained popular acceptance world wide web straightforward choice traditional soap based services however present rest based service implementation pre defined security protection methods paper present defense mechanism rest based web service attacks called rest ids defense depth network security web service layer rest ids intelligent mechanism employs statistical approach stateof art text mining based anomaly detection tmad model detect unknown novel vulnerabilities sensitive payload attacks
allogeneic hematopoietic stem cell transplantation remains sole curative option myelofibrosis many transplantation recipients receive reduced intensity conditioning ric regimen owing age comorbidities however little published evidence guide choice ric regimen study compared outcomes patients received frequently used ric regimens patients myelofibrosis fludarabine busulfan fludarabine melphalan total patients underwent ric allograft procedure group group developed complex statistical model involving weighting adjustment permit comparison groups weighting incidence acute graft versus host disease gvhd group group corresponding incidence chronic gvhd respectively year progression free survival group versus group year overall survival rate group versus group nonrelapse mortality nrm group group multivariable analyses revealed significant differences pfs groups however relapse rate significantly lower group hazard ratio whereas trend toward reduced nrm seen group hazard ratio conclusion regimens appear efficient mediating disease control used successfully condition patients myelofibrosis regimen appears induce nrm regimen augmented control disease leading comparable overall survival rates regimens american society blood marrow transplantation
many applications developed development areas environmental monitoring detecting construction malfunctions smart houses tracking targets applications require good orientation nodes relative global reference system order provide geographical information important paper review several localization principles discuss issues localization algorithm design present numerical simulation focus evaluation error spatial distribution mobile terminal positioning cellular networks prove position error depends placement network nodes relation terminal location also demonstrate optimal solution algorithm achieved reference nodes positions almost equidistant mobile terminal position future sensor networks involve movable sensor nodes new localization algorithms need developed handle moving nodes proposed positioning algorithm able solve issue accurate manner
objective objective present study compare efficacy two forms menopausal hormone therapy alleviating vasomotor symptoms insomnia irritability early postmenopausal women years methods total women aged within years final menstrual period randomized receive oral conjugated estrogens cee transdermal estradiol micronized progesterone placebos pbos menopausal symptoms recorded screening months postrandomization differences proportions women symptoms baseline follow time point compared treatment arm using exact tests intent treat analysis differences treatment effect race ethnicity body mass index tested using generalized linear mixed effects modeling results moderate severe hot flashes baseline pbo cee night sweats baseline pbo cee reduced significantly months women randomized either active hormone compared pbo symptoms significant differences active treatment arms insomnia irritability decreased baseline months postrandomization groups intermittent reduction insomnia active treatment arms versus pbo cee effective pbo months effective pbo months neither hormone treatment significantly affected irritability compared pbo symptom relief active treatment versus pbo significantly modified body mass index race ethnicity conclusions recently postmenopausal women similar substantial reductions hot flashes night sweats lower conventional doses oral transdermal estrogen reductions sustained years insomnia intermittently reduced compared pbo hormone regimens
purpose assess frequency blood glucose level higher non diabetic patients presenting fdg pet methods reviewed electronic medical record emr lymphoma patients least one fdg pet july june extracted blood glucose level time fdg pet year time period previous pet scans patients patients diabetic status determined emr results one hundred seventeen patients scans included non diabetic scans diabetic patients scans blood glucose level ranged nondiabetic patients diabetic patients non diabetic patient glucose level higher occasion one scan performed glucose scans performed glucose level less nine diabetic patients glucose level less prior scans diabetic patients glucose level higher prior pet least one occasion conclusions non diabetic patients blood glucose level lower limit recommended range prior fdg pet scans case diabetic patients conclude measuring blood glucose level prior fdg pet may limited diabetic patients
objective peak number oocytes reached intrauterine development numbers decline reserves depleted woman enters menopause premature ovarian insufficiency poi process follicle depletion occurs young age generally taken years condition affects women study investigate whether women poi experienced different perinatal milieu reflected birth weight prematurity study design retrospective case control study evaluated whether women diagnosed poi different birth weight prematurity rate weeks compared women aged natural menopause controls binary logistic regression models used analyze data correct smoking women poi controls recruited results women diagnosed poi born prematurely compared controls corrected gestational age women poi different birth weight compared controls consequence design study mean age time interview differed significantly groups years respectively women diagnosed poi controls years oral contraception use smoking age menarche bmi education levels similar two groups conclusion findings indicate prematurity risk factor poi prenatal factors contributing prematurity postnatal factors result prematurity may lead early follicle depletion elsevier ireland ltd rights reserved
patients rheumatoid arthritis different ethnic groups present elevated levels antibodies proteus mirabilis finding implicates mirabilis development aim study investigate importance mirabilis etiopathogenesis greek patients study patients healthy controls included class specific antibodies igm igg iga three human cross reactive non cross reactive synthetic peptides mirabilis hemolysin hpmb urease urec urease uref performed subjects using elisa method patients elevated levels igm igg iga antibodies hpmb urec proteus peptide significantly different compared healthy controls correspondingly also elevated levels igm igg iga antibodies uref proteus peptide non cross reactive human tissue antigens observed significant difference compared healthy controls anti peptide antibodies patients showed significant correlation rheumatoid factors erythrocyte sedimentation rate esr reactive protein crp especially patients divided subgroups according receiving treatment greek patients present elevated levels antibodies mirabilis antigenic epitopes north european populations albeit greek patients presenting cross reaction antigen low percentage results indicate mirabilis molecular mimicry mechanism leads inflammation damage joints
modern unvegetated rivers flowing aeolian dune fields demonstrate potential analogues pre vegetation fluvial landscapes prominent example contained lencois maranhenses brazil coastal aeolian system hosting semi perennial rio negro remotely sensed images covering years display rhythmic expansion wind driven shift single threaded sinuous fluvial trunks alternating wider braided plains sinuous tracts feature mid channel bank attached bars including expansional point bars subdued relief morphology accretion sediment transport unvegetated point bars rio negro compared morphodynamics vegetated meandering rivers unvegetated point bars composed large coalescent unit bars lack apparent scroll topography preferentially attached channel banks located windward side river course unvegetated meanders expansional behaviour related downwind channel trailing point bars maintain expansional planform despite spatial confinement induced aeolian dunes channel flow impingement onto cohesion less banks favours scouring deep pools along bar tails host bank collapse deposits subsequently reworked new bars analogies precambrian rivers suggest ancient unvegetated fluvial landscapes unequivocally featured low sinuosity especially characterized low gradient stable discharge inference supported ongoing studies proterozoic fluvial aeolian systems canadian shield lack scroll topography introduces overlap low sinuosity fluvial facies models underscoring value observing ancient fluvial deposits planform along sections palaeodrainage channel bodies attached bars compared
mechanosensory neurons detect physical events local environments tissues innervate studies mechanosensitivity neurons nerve endings gut related firing strain wall tension pressure digital image correlation dic technique materials engineering adapted measure local physical environments afferent neurons high resolution flat sheet preparations guinea pig distal colon set arrays tissue markers vitro firing single viscerofugal neurons identified extracellular colonic nerve recordings locations viscerofugal nerve cell bodies inferred mapping firing responses focal application nicotinic receptor agonist dimethyl phenylpiperazinium iodide mechanosensory firing recorded load evoked uniaxial biaxial distensions distension caused movement surface markers captured video imaging dic tracked markers interpolating mechanical state gut location viscerofugal nerve cell body technique revealed heterogeneous load evoked strain within preparations local strains viscerofugal nerve cell bodies usually smaller global strain measurements correlated closely mechanosensitive firing circumferential longitudinal strain activated viscerofugal neurons simultaneous loading circumferential longitudinal axes caused highest levels viscerofugal neuron firing multiaxial strains reflecting tissue shearing changing area linearly correlated mechanosensory firing viscerofugal neurons viscerofugal neurons mechanically sensitive local circumferential local longitudinal gut strain appear lack directionality stretch sensitivity
aim present study investigate levels circulating relation expression tumor necrosis factor alpha tnf monocytes serum levels tnf macrophage inflammatory protein mip migraine patients numerous studies revealed controversial changes components immune system attacks interictal period migraine patients study included migraineurs controls levels tnf mip measured peripheral monocytes sera enzyme linked immunosorbent assay elisa method monocyte expression tnf also analysed immunostaining serum concentrations higher expression tnf monocytes decreased migraineurs serum mip level correlated verbal rating scale vrs mip ratio monocytes correlated visual analogue scale vas mip ratio correlated migraine severity migsev pain scores serum concentration correlated migraine duration years increased serum depletion tnf monocytes orchestrate components immune system interictal period
geotextile tubes widely used dewatering high water content fine sediments fine sediments include lake sediments organic soils coal combustion products generally low shear strength several researchers emphasized effect retained sediment filter cake properties dewatering performance stability geotextile tubes maintaining retained sediment properties particular permeability shear strength allows faster dewatering time better retention sediments improved stability geotextile tubes multiple filling stages tube stacking process several studies shown use synthetic fibers increase shear strength sand silt clays however use fibers improve strength retained sediments geotextile tubes explored study three synthetic fibers varying length diameter used evaluate effect fibers dewatering performance shear strength fine sediments cationic polyacrylamide flocculant used optimum conditioner selected sediment fibers mixed flocculant conditioned slurry fiber concentration mass dry solids effect fibers undrained shear strength dewatered sediments evaluated using lab vane test fall cone test undrained unconsolidated triaxial test jar tests pressure filtration tests also conducted evaluate effect fiber required flocculant dosage dewatering performance based results study fiber type found optimum fiber concentration yielding approximately increase undrained shear strength also found diameter length fibers play significant role altering undrained shear strength tested sediments relatively short thick fiber yield increase shear strength tested fiber concentrations whereas thin fibers similar length increased shear strength furthermore found use fibers concentration decreases required optimum doses flocculant increases dewatering rate effluents
introduction massive rotator cuff tear repair results variable main purpose study compare functional outcome two procedures open repair autologous quadriceps patella tendon patch arthroscopic suture study hypothesis significant difference results two techniques material methods retrospective study included patients younger years operated massive rotator cuff tear exclusion criteria comprised history dislocation fracture surgery osteoarthritis affected shoulder infra supra spinatus fatty degeneration equal greater stage two consecutive groups distinguished group comprised patients shoulders mean age years treated open repair using quadriceps tendon autograft group comprised patients shoulders mean age years treated arthroscopic repair results preoperatively mean constant score group group pain score strength subacromial space respectively respectively months mean follow constant score group group pain gain strength subacromial space respectively complications rate group specific complications group conclusion functional improvement significant comparable groups quadriceps tendon harvesting associated high morbidity technique increased subacromial space level evidence retrospective single center published elsevier masson sas
since macroalgal blooms ulva prolifera also called green tides occurred every summer yellow sea causing environmental economic problems number studies used satellite observations estimate severity blooms estimating bloom size duration however critical bloom parameter namely biomass never objectively determined due lack measurements study laboratory experiments conducted measure prolifera biomass wet weight per unit area corresponding spectral reflectance robust relationship established link biomass per area reflectance based floating algae index fai lab based model validated situ measurements estimated relative uncertainty million tons june minimum daily biomass million tons ability estimate prolifera biomass given locations near real time modis images expected significantly enhance capacity existing monitoring system provide quantitative information decision making authors published elsevier inc
paper reviews history technology bulk crystal growth process developed early honeywell electro optics division presently bae systems electronic solutions crystal growth process name dme acronym department name detector materials engineering accelerated crucible rotation technique acrt vertical traveling heater method growth process crystal growth occurred pseudobinary system acrt mixing allowed lower density higher value growth nutrient upper region ampoule replenish depleted melt allowed growth constant value higher density material grown research production growth process yielded single crystals improved purity compositional uniformity precipitate density reproducibility comparison solid state recrystallization bulk growth techniques radial longitudinal nonuniformities value reduced net electrically active background impurities exceed electron mobilities excess observed structural defects less measured precipitates observed result material improvements long wavelength infrared lwir photoconductive devices fabricated dme material highly desired performance characteristics
ideal diode equation regularly used describe characteristic single junction solar cells connection diode equation fundamental physics application boltzmann approximation describe fluxes photons emitted cell paper approximation used derive analytic characteristics three photovoltaic high efficiency concepts intermediate band solar cells solar cells optically coupled downconverters three concepts share common feature allow excitation electrons least three energy levels assures better utilization solar spectrum leads limiting efficiencies surpassing shockley queisser limit although considerablysimpler implementand use resulting characteristics reproduce limiting efficiencies obtained full detailed balance models simplicity facilitates intuitive understanding devices presented models also potential serve useful framework modeling savings computation time complexity
background existing diverse bottom estimations direct costs associated depression germany motivated detailed patient level analysis depression related treatment drt costs drc comorbidity methods large sickness fund claims data used retrospectively identify patients aged years new onset depression treatment january february follow december describe drt estimate associated drc predict drc generalised linear model results total patients analysed mean direct drc predictors drc regarding psychiatric comorbidities delusion psychotic disorders personality disorders drcratio alcohol drug addiction abuse alcohol drugs predictors drc regarding medical comorbidities rheumatoid arthritis atherosclerosis pregnancy osteoarthritis patients received intense specialised drt general practitioner medical specialist psychotherapist medical specialist psychotherapist hospital serious psychiatric comorbidity nearly tripled depression related hospitalisation rates limitations seasonal affective disorder missing psychiatric outpatient clinic data must considered conclusions estimated drc significantly assessment german national guideline differing definitions observation period cost attribution might explain differing german drc results signs hospital psychiatric comorbidity bias indicate overestimation hospital drc identified associations drc certain medical diseases older adults warrant research one quarter patients severe depression diagnosis might lack specialist treatment elsevier rights reserved
rapid population growth climate impediments poor implementation regulatory frameworks challenging political relations led exploitation conventional water resources middle east situation may impelled box thinking advances research non conventional water resources including desalination wastewater reuse rainwater harvesting long distance water transfer paper aims assess extent research non conventional water resources middle east identify original innovative research findings cyprus egypt israel lebanon palestinian territories sudan syria turkey selected purpose systematic online library search scientific literature conducted relations national indicators number articles citations assessed increasing trend number articles addressing non conventional water resources desalination popular research topic citations average followed wastewater reuse citations average publication desalination articles increased significantly since substantial number authored private companies non conventional approaches include commercial salt production desalination plant strengthening wastewater reuse standards based adverse effects long term reuse application water harvesting plough large scale rangeland rehabilitation development long sea pipeline water transfer research site effects environmental impacts lacking investment research capacity element social capital contribute water resources diversification sustainable solutions water stressed humid countries
purpose assess effect wearing close fitting neoprene shorts swinging leg movement discrimination scores elite level australian football players twenty players swinging leg assessed using active movement extent discrimination apparatus ameda wearing close fitting neoprene wearing loose fitting running shorts subjects randomly allocated one shorts conditions prior repeating test condition ameda used assess accuracy subjects judge extent standing backward swinging leg movement corresponding late swing early stance phase running subject performed movements made five randomly set physical limits without aid vision made judgment perceived limit position accuracy judgments movement discrimination score calculated subject condition subjects grouped tow high neuromuscular control ability use proprioception controlling active movements without vision based loose shorts score analysis performed scores obtained limb subjects two groups two shorts wearing conditions main effect wearing close fitting shorts cohort treated whole significant interaction effect obtained whereby mean score low neuromuscular control ability group improved wearing neoprene shorts reduced high ability group wearing close fitting neoprene shorts beneficial effect leg swing judgment accuracy subjects tow neuromuscular control ability conversely leg swing judgment accuracy subjects high ability reduced wearing neoprene shorts sports medicine australia published elsevier ltd rights reserved
paper presents finite control set modelpredictive control fcs mpc three phase quasi zsource qzs four leg inverter unbalanced load condition key novelty proposed control approach eliminating double line frequency ripple inductor current simple effective approach proposed four leg qzs inverter output filter handle buck boost conversion features single stage furthermore fcs mpc based control algorithm helps maintaining balanced point common coupling voltages stand alone unbalanced loads behavior predictive controller investigated different operating conditions robustness qzs network filter parameter variations also studied furthermore effect double line frequency ripple relation inductor current constraint tackled comprehensively verify performance proposed approach simulation experimental studies performed balanced unbalanced loads
resting frontal encephalographic eeg asymmetry often conceptualized trait marker depression influenced occasion specific factors including time year time day recording session demonstrated recently peterson harmon jones current study examined influence seasonal chronological variables resting frontal asymmetry also assessed whether different reference montages surface transformations equally susceptible influences direct replication attempt contrary previous findings simple time year time day interaction found time awake recording however important moderating variable relationship photoperiod time day eeg asymmetry scores based current source density csd transformed data however appeared less vulnerable influences providing evidence suggest csd transform may advantageous examining stable trait estimates frontal eeg asymmetry elsevier rights reserved
thermoacoustic instabilities gas turbines aeroengine combustors fall within category complex systems described phenomenologically using nonlinear stochastic differential equations constitute grounds output model based system identification shown recently one extract governing parameters instabilities namely linear growth rate nonlinear component thermoacoustic feedback using dynamic pressure time series highly relevant practical systems actively controlled due lack cost effective actuators thermoacoustic stability given linear growth rate results combination acoustic damping coherent feedback flame paper shown possible quantify acoustic damping system thus separate contribution linear growth rate one flame achieved postprocessing simple way simultaneously acquired chemiluminescence acoustic pressure data provides additional approach unravel observed time series key mechanisms governing system dynamics straightforward method illustrated using experimental data combustion chamber operated several linearly stable unstable operating conditions
background aims mild cognitive impairment mci present patients early stage parkinson disease however difficult detect subtle impairment without objective cognitive testing methods data obtained parkinson progression marker initiative participants administered montreal cognitive assessment moca brief neuropsychological battery participants classified mci moca scored standard deviation normative mean domains based upon established criteria sensitivity specificity clinical detection mci determined results overall accuracy clinical detection mci although clinical determination highly specific confidence interval sensitivity poor conclusion identifying mci early stage based clinical interview alone appears insufficient inclusion objective cognitive tests allowing normative sample comparisons needed increase detection cognitive impairment population
serotonin circadian systems principal regulatory networks brain consists unique set neurons make widespread neural connections defined gene network transcriptional regulators signaling genes subserve serotonergic circadian function genetic level master regulatory networks brain extensively intertwined reciprocal circuit connections expression key genetic elements serotonin signaling clock neurons expression key clock genes serotonergic neurons reciprocal connections serotonin circadian systems likely importance neurobehavioral disorders suggested convergent contribution similar range mood disorders including seasonal affective disorder sad bipolar disorder major depression suggested overlapping relationship developmental disorder autism spectrum disorder review neuroanatomical genetic basis serotonin circadian interactions brain potential relationship neurobehavioral disorders recent work examining effects circadian system genetic perturbation serotonergic system well molecular behavioral effects developmental imprinting circadian system perinatal seasonal light cycles published elsevier ltd behalf ibro
background prevalence allergic diseases impaired pulmonary function may high children born prematurely study aimed assess pulmonary function prevalence asthma atopic diseases allergic sensitisation patients methods cross sectional study conducted children aged years born prematurely birth weight january may exclusion criteria major malformations acute respiratory disorders international study asthma allergies childhood questionnaire applied followed allergic skin prick test spirometry results study included children aged years born mean gestational age weeks prevalence current asthma severe asthma rhinitis flexural eczema positive skin prick test frequencies children values predicted fvc fev fev fvc ratio prevalence children fef predicted value positive bronchodilator response observed cases altered pulmonary function factors associated altered pulmonary function oxygen dependency days life presence wheezing childhood infant height conclusions high prevalence severe asthma allergic sensitisation altered pulmonary function among children adolescents born prematurely bronchopulmonary dysplasia history wheezing risk factors altered pulmonary function seicap published elsevier espana rights reserved
pulmonary mucormycosis life threatening fungal infection patients hematologic malignancies early accurate diagnostic modalities urgently needed conducted polymerase chain reaction pcr assay targeting fungi peripheral blood four patients hematologic malignancies strongly suspected four patients rhizopus species identified two patients cunninghamella absidia species one based molecular findings patients successfully treated via targeted therapy liposomal amphotericin report pcr analysis proved useful managing patients hematologic malignancies
pathological consequences decreased protein dependent protease inhibitor zpi levels remain yet unclear despite growing body evidence supports involvement increased thrombotic risk purpose present study fold evaluate plasma concentrations protein zpi patients essential thrombocythemia determine significance thrombotic complications median range plasma concentrations patients lower significantly healthy individuals hand median range plasma concentrations zpi said patients meaningfully lower reference group zpi importantly study revealed statistically significant lower concentration zpi patients presence jakvf mutation relative patients without mutation versus zpi versus additionally significant differences concentrations zpi found patients venous thrombotic episodes compared healthy individuals versus zpi versus recapitulate results suggest deficiency may increase tendency thrombosis patients
chapter reviews smart high performance materials currently used protective textiles investigated researchers protective applications fibres high strength heat resistance chemical resistance electrical conductivity discussed materials piezoelectric properties sensing actuation phase change materials absorb release heat shear thickening fluids briefly covered protective films electrospun nanofibre membranes methods manufacture described nanofibres derived natural sources applications carbon nanotubes reviewed discussion given outstanding properties individual nanotubes yet fully exploited macroscopic assemblies pure nanotube fibres composites polymer resin
accidents many share control engineering application including aircraft carrier landing process directly related human error order identify human error assess reliability human system interaction hsi carrier landing control theoretic based simulation method proposed simulator combines pilot control cognition model exploits human error mechanism describe dynamic characteristics carrier landing performance shaping factors psfs also taken consideration represent likelihood human error moreover mission reliability proposed appropriate metric hsi quantitative simulation human error produced hsi could presented demonstrated dynamically performance proposed method tested case study
smart grid electrical grid uses digital information communication technology gather information like digital systems security privacy crucial smart grid however security privacy protection inevitably introduce computational complexity overhead smart grid systems usually operated large scale computational efficiency challenging issue paper propose efficient secure billing system smart grid featuring privacy preserving data aggregation show system offers better privacy protection computational efficiency comparison existing protocol security analysis indicates protocol achieves privacy preserving electricity reading aggregation billing perfect forward secrecy system session keys identity authentication data integrity confidentiality also shows even allow collusion server gateways user privacy still achieved copyright john wiley sons ltd
particle filtering eminent simulation based state estimation technique capable handling massive data sets diverse external factors effective selection importance density plays pivotal role performances pfs preventing degeneracy problems early stages process also taking transition prior likelihood account likelihood appears tail prior end propose novel importance density selection scheme based minimum relative entropy principle theoretical derivation proposed scheme presented effectiveness evaluated various sampling schemes exist literature using synthetic experiments finally performance proposed minimum relative entropy based density selection scheme successfully demonstrated short term electricity demand forecasting company located miami usa note practitioners paper motivated necessity reducing utility costs terms energy consumption large scale enterprises determination lowest cost method providing required amount electricity heavily relies accurate load demand forecast addition demand forecasting problems also exist various fields including supply chain management manufacturing microgrid networks paper provides eminent approach estimate posterior state demand forthcoming periods given prior states past demand measurements paper mathematically derive method using minimum relative entropy principle validate proposed method series synthetic experiments designed case study short term electricity demand forecasting carried results obtained proposed method benchmarked obtained four approaches exist literature future research extend application scope paper tracking naval radar systems state estimation distributed power systems renewables
paper presents investigation premature damage expansion joints bearings long span suspension bridges failure patterns locations mechanism presented discussed according field monitoring time frequency domain analyses observed small rapid girder movements contributed mostly large cumulative movements resulting accelerated fatigue damage wear expansion joints bearings several damage mitigation measures applied including use durable friction material control springs movement restraint belts effectiveness examined field observation supplementary control measure using viscous dampers finally suggested influence various damper parameters discussed based proposed transient finite element analysis method elsevier ltd rights reserved
several commercial financial expert systems used trading stock exchange however predictions somewhat limited since primarily rely time series analysis market rise internet new forms collective intelligence google wikipedia emerged representing new generation crowd sourced knowledge bases collate information publicly traded companies capturing web traffic statistics reflect public collective interest google wikipedia become important knowledge bases investors research hypothesize combining disparate online data sources traditional time series technical indicators stock provide effective intelligent daily trading expert system three machine learning models decision trees neural networks support vector machines serve basis inference engine evaluate performance expert system present case study based aapl apple nasdaq stock expert system accuracy predicting next day aapl stock movement outperforms reported rates literature results suggest knowledge base financial expert systems benefit data captured nontraditional experts like google wikipedia diversifying knowledge base combining data disparate sources help improve performance financial expert systems use simple machine learning models inference rule generation appropriate rich knowledge database finally intelligent decision making tool provided assist investors making trading decisions stock commodity index elsevier ltd rights reserved
background short long term exposure traffic related air pollutants associated asthma reduced lung function hypothesized short term indoor exposure fine particulate matter vanadium would associated altered buccal cell dna methylation targeted asthma genes decreased lung function among urban children nested subcohort african american dominican children methods six day integrated levels air pollutants measured children homes age repeated months later buccal samples collected repeatedly visits cpg promoter loci asthma genes interleukin interferon gamma ifn gamma inducible nitric oxide synthase nosa arginase arg pyrosequenced lung function assessed results exposure associated lower dna methylation ifn gamma exploratory analyses levels associated lower methylation proinflammatory nosa cpg among asthmatic overweight obese children nonasthmatics short term exposure appeared associated lower lung function reduced scores forced expiratory volume one second fev fev forced vital capacity fev fvc forced expiratory flow fvc fef conclusions exposure associated altered dna methylation allergic proinflammatory asthma genes implicated air pollution related asthma however short term exposure appeared associated decrements lung function among urban children
loss cell polarity impairs organ development function also serve one first triggers oncogenesis two groups simultaneously reported existence special pathway maintaining epithelial polarity face environmental stressors pathway ampk key sensor metabolic stress stabilizes tight junctions preserves cell polarity thereby maintains epithelial barrier functions accumulating evidence since shown pharmacologic activation ampk metformin protects epithelial barrier multiple environmental pathological stressful states suppresses tumorigenesis ampk protects epithelium remained unknown recently aznar identified giv girdin novel effector ampk cell cell junctions phosphorylation giv single site ampk appears necessary sufficient strengthening tight junctions preserving cell polarity epithelial barrier function face energetic stress review fundamentals specialized signaling pathway buttresses cell cell junctions stress induced collapse discuss pathophysiologic relevance context variety diseases including cancers diabetes aging growing list beneficial effects ampk activator metformin
systematic method combines shape curvature entropy computational fluid dynamics analyses proposed study creating automobile shapes various automobile shapes evaluated proposed method parameters including curvature entropy drag coefficient configuration calculated determine optimal shape design first shapes commercially available car models collected curvature entropy values determined proposed equation meanwhile drag coefficient car model determined computational fluid dynamics simulation values compared results indicated positive correlation automobile shape curvature entropy value drag coefficient therefore curvature entropy proven suitable indicator estimating automobile shape aerodynamic performance new automobile shape design required number numerical analyses reduced utilizing proposed curvature entropy calculation time spent designing automobile shape greatly reduced
previous research response inhibition psychopaths failed find consistent evidence aberrant inhibitory ability despite strong expectations contrary however previous examinations utilised inhibition paradigms suffer critical shortcomings lack ecological validity overly simplistic response criteria assess inhibition conditions close demands everyday settings current study employs parametric task male offenders additionally rather treating psychopathy categorical descriptor dimensional approach taken assess relationship individual psychopathic traits response inhibition performance results indicate significant relationships response inhibition individual facets psychopathy measured psychopathy checklist screening version positive relationship found inhibitory ability interpersonal aspects psychopathy reflecting enhancement inhibitory functioning scoring high facet addition negative association found psychopathic lifestyle characteristics response inhibition whereas negative association mirrors conceptualisation lifestyle facet positive association interpersonal psychopathic aspects response inhibition might reflect propensity adaptive behaviour enables psychopaths adequately manipulate victims mask true nature
background waterpipe tobacco smoking increased among youth across globe including continues common traditional form smoking tobacco pakistan range behavioral pharmacological therapies available support people quitting cigarette smoking however little evidence exists efficacy therapies achieving abstinence among waterpipe tobacco smokers objective study assess efficacy varenicline added behavioral support waterpipe tobacco smoking cessation measuring biochemically validated continuous abstinence waterpipe tobacco smokers methods design two arm double blind placebo controlled randomized trial conducted four districts punjab pakistan study participants include adults using waterpipe without concomitant cigarette bidi forms tobacco smoking daily basis least months willing quit individually randomize participants one two arms trial participants intervention arm receive varenicline behavioral support control arm receive placebo behavioral support primary outcome continuous abstinence least months week biochemically verified carbon monoxide level ppm secondary outcomes include biochemically verified day point abstinence weeks lapses relapses different assessment points tertiary outcomes include assessment withdrawal symptoms using mood physical symptoms scale mpss smoking dependency using lebanon waterpipe dependency scale lwds monitoring adverse outcomes discussion efficacy trial would require subsequent effectiveness trial definitive evaluation intervention
vertebral fracture assessment vfa dxa accepted tool adults however use children assessed aim study evaluate dxa vfa morphometric analysis mxa using lunar idxa bone densitometer spinal radiographic assessment identification vertebral fractures children spine vfa acquired day children forty children considered high risk fracture metabolic bone specialist referred spinal another children recruited part prospective fracture study considered low risk vertebral fracture agreement vfa assessed expert paediatric radiologist two paediatricians expertise bone pathology agreement mxa assessed expert paediatric radiologist two clinical scientists experienced paediatric radiographer vertebrae ranked normal mild moderate severe deformity respectively levels agreement calculated using cohen kappa score evaluating data readable vertebrae mild moderate severe vertebral fractures identified subjects least one mild moderate severe fracture respectively depending rater vertebrae evaluable contrast evaluable vfa evaluable mxa moderate agreement found raters kappa vfa kappa vfa kappa contrast slight agreement noted raters mxa kappa vfa mxa kappa agreement substantially improved deformities dichotomised normal mild versus moderate severe kappa detection moderate severe fractures sensitivities specificities vfa mxa respectively study demonstrates vfa good detecting moderate severe vertebral fractures given significant radiation dose saving vfa compared vfa recommended diagnostic tool assessment moderate severe vertebral fracture children crown copyright published elsevier inc rights reserved crown copyright published elsevier inc rights reserved
selective serotonin reuptake inhibitors ssris reported increase cognitive performance clinical studies alzheimer disease however lack evidence supporting efficacy ssris cognition enhancers role ssris treatment remains largely unclear characterized impact fluoxetine flx well known ssri neurons dentate gyrus hippocampus middle aged months old appswe psende app transgenic model mice found intraperitoneal injection flx day weeks effectively alleviated impairment spatial learning ability middle aged app mice evaluated using morris water maze importantly number neurons hippocampal significantly increased flx additionally flx reduced deposition beta amyloid inhibited gsk beta activity increased level beta catenin middle aged app mice collectively results study indicate flx delayed progression neuronal loss hippocampal middle aged mice effect may underlie flx induced improvement learning ability flx may therefore serve promising therapeutic drug
data driven models used efficient proxy model complex concepts engineering common engineering practice optimize controllable input parameters model increase efficiency operations machine learning used predict rate penetration rop drilling great accuracy shown hegde wallace gray paper illustrates use machine learning predict increase rop effectively machine learning model first used predict rop input parameters weight bit wob rotations per minute drill bit rpm flow rate drilling mud input parameters modified increase rop process applied field drilling data vertical well consisting different rocks formations procedure used determine maximum achievable rop formation map operational guidelines drilling pad wells post drilling analysis conducted pad wells cut costs save time drilling model innovative surface measured parameters used without priori requirements geological laboratory drilling data published elsevier
golgi apparatus center lipid metabolism final target ceramide pathway may result apoptosis work localization highly hydrophobic hypericin followed time resolved imaging nbdc fluorescent ceramide glioma cells decrease nbdc fluorescence lifetimes cells indicates hypericin also follow pathway known ceramide hypericin significantly influence protein kinase pkc activity western blotting analysis shows increase pkc delta autophosphorylation ser pkc delta glioma cells incubated hypericin confocal fluorescence microscopy distinguishes pkc delta localization related compartments nucleus experimental numerical methods combined study pkc delta cell line image processing based conceptual qualitative description combined numerical treatment via simple exponential saturation model describes redistribution pkc delta nucleus related compartments hypericin administration results suggest numerical methods significantly improve quantification biomacromolecules pkc delta directly fluorescence images obtained outputs complementary equal typical used methods biology
radioactive iodine therapy commonly used adjuvant therapy follicular papillary thyroid carcinoma ptc treatment graves disease basis therapy accumulation radioactive iodine sodium iodide symporter nis thyroid gland expression nis extrathyroidal tissues islets pancreas reported radioactive iodine uptake pancreatic beta cells potentially damage cells study discuss possible associations radioactive iodine glucose intolerance overall radioactive iodine uptake pancreas may damage beta cells predispose patients glucose intolerance type diabetes particularly patients exposed radioactive iodine therapy following total thyroidectomy studies needed clarify confirm association
addition algorithm concept oriented training problem solving computer programming introductory computer science classes may contain programming projects themes relevant young people motivation theme driven programmers practice coding create digital artefact related domain interested want learn necessary programming concepts learned way diving programming contribution presents examples theme driven projects related text mining web cam image processing development learning process supported metaphorical explanations programming concepts algorithmic ideas experiments simple programming statements stories code fragments
mammals centromere definition involves histone variant cenp centromere protein deposited chaperone hjurp holliday junction recognition protein alterations process impair chromosome segregation genome stability also compromised inactivation cancer found cenp hjurp transcriptionally regulated null human tumors using established mouse embryonic fibroblast mef model combining inactivation hras oncogene expression reproduced similar regulation hjurp cenp delineate functional cde chr motifs within hjurp cenpa promoters demonstrate roles mediated repression assess importance hjurp regulation transformed murine human cells used crispr cas approach remarkably depletion hjurp leads distinct outcomes depending status functional elicits cell cycle arrest response whereas null transformed cells absence arrest enables loss hjurp induce severe aneuploidy ultimately apoptotic cell death thus tested impact hjurp depletion pre established allograft tumors mice revealed major block tumor progression vivo discuss model epigenetic addiction hjurp chaperone represents achilles heel deficient transformed cells
nature daylight found positively influence health findings however found two separate research domains paper presents overview effects found daylight nature health health related concepts stress mood executive functioning self regulation overlap effects found occurrence phenomena paper points need consider daylight factors investigating effects nature vice versa furthermore existence possibly shared underlying mechanisms discussed need unify research paradigms dependent variables used two research fields last view beneficial effects phenomena health objective raise awareness amongst general public designers health practitioners use naturally available phenomena full potential
objectives analyze whether yoga meditation use associated body dis satisfaction weight control methods australian women methods women ages australian longitudinal study women health surveyed regarding body satisfaction weight control behaviors yoga meditation practice associations body satisfaction weight control methods yoga meditation practice analyzed using chi squared tests multiple logistic regression modelling results women overweight obese sixty five percent women normal body mass index bmi approximately women overweight obesity wanted lose weight least one four women normal bmi dissatisfied body weight shape two three women overweight obesity common weight control methods included exercising cutting meal sizes cutting sugars fats yoga meditation practiced frequently women occasionally women yoga meditation users normal bmi less likely dissatisfied body weight shape yoga meditation users likely exercised followed low glycemic diet diet books women obesity occasionally using yoga meditation also likely used fasting smoking lose weight conclusion yoga meditation users normal bmi appear satisfied body weight shape non yoga meditation users women normal bmi overweight tend rely healthy weight control methods women obesity occasional using yoga meditation may likely utilize unhealthy weight control methods elsevier inc rights reserved
model created calculating balanced diversion ratios flow rate sediment branches bifurcated river model based extremity law energy dissipation rate involves solving simultaneous equations flow sediment motion uniform flow open channel model verified measured data obtained meizizhou baguazhou branches yangtze river china parameters influence diversion ratios river width channel roughness total inflow analysed found balanced diversion ratios sensitive river width roughness total inflow measures regulate baguazhou branch compared analysed conclusions study provide theoretical basis future regulation baguazhou river branch
several devices load cells pressure sensors among others provide differential outputs given present high resolution analog digital converters adcs differential inputs fully differential circuits required adapt sensor output adc input paper proposes conditioning circuit allows adjusting differential common mode signals levels required adc design example presented prototype built tested transforms differential input signal common mode voltage differential output signal respectively shows input referenced peak peak noise results dynamic range bit noise free resolution signal bandwidth
conceptual seismic design qualitative design seismic performance structure corresponding design quantitative design based seismic response analysis qualitative conceptual design reliable quantitative numerical design long span arch bridges many uncertainties quantitative seismic response analysis typical earthquake damage cause damage long span arch bridges presented home abroad general requirements conceptual seismic design long span arch bridge discussed aspects engineering site selection reasonable bridge structure system layout scheme foundation form design principles avoiding brittle failure long span arch bridges given use high strength materials improving overall ductility setting redundancy elements multi seismic defense lines main components secondary members structure divided seismic capacity main component secondary member different design seismic conceptual design method proposed general requirements design principles design methods also applied long span cable stayed bridge suspension bridge
paper scrutinize asymptotic behavior nonlinear problem models vertical vibrations suspension bridge single span road bed modeled extensible viscoelastic beam simply supported ends suspended rigid immovable frame means distributed system vertical one sided elastic springs constant axial force applied one end deck time independent vertical loads allowed model obtain original results including existence regular global attractor spite extremely weak dissipation due convolution term result achieved exploiting exponential decay memory kernel
many applications top query important operation return set interesting points potentially huge data space existing algorithms either maintaining many candidates requiring assistant structures built specific attribute subset returning results probabilistic guarantee process top query massive data efficiently paper proposes sorted list based tkap algorithm utilizes data structures low space overhead efficiently compute top results massive data round robin retrieval sorted lists tkap performs adaptive pruning operation maintains required candidates stop condition satisfied adaptive pruning operation adjusted information obtained round robin retrieval achieve better pruning effect adaptive pruning rule developed paper along theoretical analysis extensive experimental results conducted synthetic real life data sets show significant advantage tkap existing algorithms
article addresses mainly questions roles fluid systems particular digital ones industrie environment three roles general machines subsystems components role machines production system role subsystems components machines produced conditions manufacturing fluid systems components setting roles discussed examples digital hydraulic solutions fulfill roles excellently presented feature simplicity robustness hardware components transfer functionality software concluded components subsystems support successful realization type production systems decisively
cross section questionnaire based study carried january till december compare intellectual wellness awareness basis gender teachers basic sciences medical universities karachi pakistan data collected public private medical universities karachi pakistan questionnaire tailored wellness wheel responses aggregated eight questions dimension obtain aggregate score reliability questionnaire measured using cronbach alpha average intellectual score minimum score maximum frequency keeping informed research updates significantly higher males emphasized significantly better awareness male medical teachers involved teaching medical sciences public private medical universities pakistan
increasing evidence suggests numerous forkhead transcription factors required repress mammalian cells phenotype among foxk ubiquitously expressed family member role foxk mediating tumor metastasis non small cell lung cancer explored investigation reduced foxk expression found lung adenocarcinoma tissues compared adjacent non tumor tissues associated better overall survival low expression also found nsclc cell lines nci cells recombinant lentivirus expressing foxk constructs shfoxk developed transfected cells nci cells immunofluorescence assay qrt pcr western blot analysis used measure change epithelial markers cadherin catenin mesenchymal markers cadherin vimentin wound healing assay transwell assay used measure relative cell invasion ability mtt assay edu assay cell cycle distribution analysis used confirm effect foxk cell proliferation chip seq qchip well luciferase reporter gene assays used detect target genes regulated foxk bioinformatics predicated potential mirnas could target foxk study demonstrated foxk played major roles nsclc emt directly targeting cadherin snail found foxk regulated nsclc cell growth suppressing expression cyclin cdk suggested foxk might multifunctional regulator nsclc expression foxk may regulated mir could serve promising therapeutic target nsclc
low body weight established risk factor osteoporosis fracture skeletal risks higher adiposity unclear appear sex specific site dependent aim study investigate associations total fat mass tfm visceral adipose tissue vat reactive protein crp bone mineral density bmd prevalent vertebral fracture men women aged years total men women aged years newcastle thousand families study cohort received dual energy ray absorptiometry dxa evaluations femoral neck lumbar spine bmd lateral spine vertebral fracture assessment whole body tfm vat lunar corescan madison usa plasma crp frax scores falls last months occupation age years also included analysis vertebral fractures less prevalent women men odds ratio bmd frax scores differ participants without women heavier higher tfm vat crp women without women greater tfm vat increased odds grade tfm vat greater vat mass increased odds prevalent mild contrast associations men sexes controlling body weight neither vat crp associated bmd conclusion irrespective bmd total visceral adiposity associated prevalent women men high fat mass particularly visceral considered assessing risk women risk factors men require investigation particularly given high prevalence american society bone mineral research
background aims direct oral anticoagulant doac agents increase risk gastrointestinal bleeding investigated doac favorable safety profile compared differences among drugs agerelated risk bleeding methods conducted retrospective propensity matched study using administrative claims data optumlabs data warehouse privately insured individuals medicare advantage enrollees created propensity matched cohorts patients non valvular atrial fibrillation incident exposure dabigatran rivaroxaban apixaban october february compared data rivaroxaban dabigatran patients data apixaban dabigatran patients data apixaban rivaroxaban patients cox proportional hazards models stratified age used estimate rates total bleeding results baseline characteristics well balanced among sub cohorts bleeding occurred frequently patients given rivaroxaban dabigatran hazard ratio confidence interval apixaban associated lower risk bleeding dabigatran rivaroxaban rates events doacs increased among patients years older apixaban lower risk association bleeding elderly dabigatran rivaroxaban median times bleeding days apixaban rivaroxaban days dabigatran conclusions population based study patients receiving doac agents found apixaban favorable safety profile rivaroxaban least favorable profile bleeding events among patient aged years older taking doacs increased age risk greatest among persons years apixaban favorable safety profile among age groups
ski jump one effective structures energy dissipation spillways spillways long practical importance safety dams major criteria hydraulic design based analytical empirical methods current study order increase chute spillway efficiency multi objective evolutionary algorithm known non dominated sorting genetic algorithm nsga utilized design optimal triangular bucket angle chute width design method two separate objective functions used first objective function equations dynamic pressure bucket jet length bucket scour depth used second objective function related construction volume chute spillway calibrating first objective function characteristics karoon iii dam used case study difference design parameters karoon iii spillway nsga algorithm method less percent according results jet length considered impressive parameter first objective function design spillway becomes frugal sharif university technology rights reserved
spondyloarthritis spa usually characterized early inflammatory involvement sacroiliac joints constitutes one important classification criteria according spondyloarthritis international society asas criteria include inflammatory spine lesions detected mri although spine involvement common axial spa spine mri lesion often retrieved spa specific found many diseases malignancy osteoarthritis present case year old woman presented worsening low back pain thoracic spine mri showing bone marrow edema bme whole vertebral body owing peculiar presentation together unresponsiveness pain nonsteroidal anti inflammatory drugs nsaids slight increase biomarker malignancy suspected therefore patient underwent bone scintigraphy single positron emission computed tomography spet positron emission tomography repeated mri without reaching diagnosis finally joints mri performed bme joints emerged fundamental formulate diagnosis axspa
introduction biologic therapy revolutionized treatment pathways psoriatic joint skin disease also provided useful tool pathological pathways condition may explored areas covered review presents data clinical biological effects targeted therapy psoriatic arthritis psoriasis therapeutic agents covered include inhibitors tnf inhibitors axis inhibitors intracellular small molecules involved transduction inflammatory signal trial data clinical imaging efficacy reviewed parallel studies biological effects tissue level pathological insights gained use treatments explored expert commentary close relationship exists specific pathological types clinical manifestations psoriatic disease including responses treatment studying relationships likely improve understanding disease enable rational selection specific treatments patients specific pathotypes
background obesity considered chronic disease difficult treat first cause death world predictable surgical approach limited patients severe obesity intermediate group candidates immediate surgery bioenterics intragastric balloon bib spatz adjustable balloon system abs currently recommended weight reduction bridge bariatric surgery methods retrospectively studied patients received bib january july prospectively studied patients receive abs july august aim study compare two balloon systems terms weight loss complications maintenance weight removal procedure median weight loss median bmi end therapy results major complications occurred month follow weight loss abs bib month followup weight loss compared previous measurement abs bib month follow weight loss compared previous measurement abs bib conclusions bib abs effective treating overweight patients bmi rate complication reported according literature significant differences two procedures terms outcomes
designing durable building envelope air flow around building plays important role buoyancy one factors affect air flow patterns contribution outdoor buoyancy air flow surrounding building studied research building studied headquarters malaysian energy commission building unique architectural outlook called diamond building due design outdoor field data air velocity ambient temperature surface temperature collected physical measurement air flow simulation carried using computational fluid dynamics software ansys total four cases studied research qualitative quantitative analyses simulation results carried show influence outdoor buoyancy effect air flow patterns results showed air flow surrounding building maximum velocity dominated buoyancy effect wind present stronger natural wind present buoyancy effect negligible practical application new findings outdoor buoyancy air flow surrounding building tropics could used important guide building design engineers researchers intention improve design building envelopes surrounding air flow significant influence building ventilation well outdoor contaminant movement penetrates building envelopes surrounding airflow considered solely contributed wind previously examined accurate airflow pattern considering buoyancy effect airflow
sensitivity specificity micrornas mirnas diagnosing glioma controversial therefore performed meta analysis systematically identify glioma associated mirnas initially screened five mirna microarray datasets evaluate differential expression mirnas glioma normal tissues next compared expression mirnas different organs tissues assess sensitivity specificity differentially expressed mirnas diagnosis glioma finally pathway analysis performed using genego identified candidate mirnas associated glioma initiation progression patient prognosis sensitivity specificity analysis indicated mir mir mir mir mir regulated mir regulated glioma ten signaling pathways showed strongest association glioma development progression pathway feedback loops interleukin signaling pathway toll receptor signaling pathway parkinson disease notch signaling pathway cadherin signaling pathway apoptosis signaling pathway vegf signaling pathway alzheimer disease amyloid secretase pathway fgf signaling pathway results indicate integration mirna gene protein expression data yield valuable biomarkers glioma diagnosis treatment indeed six mirnas identified study may useful diagnostic prognostic biomarkers glioma
interleukin heterodimeric cytokine covalently bound proteins recently closely associated development several chronic autoimmune diseases psoriasis psoriatic arthritis inflammatory bowel disease released activated dendritic cells interacts receptor cells thus promoting intracellular signaling pivotal step driven pro inflammatory axis aimed block binding cytokine cell surface receptor novel inhibitory protein binders targeted subunit human goal used combinatorial library derived scaffold albumin binding domain abd streptococcal protein ribosome display selection yield collection abd derived targeted variants called ilp binders clones analyzed elisa western blot dna sequencing provided different sequence variants characterized using silico docking combination cell surface competition binding assay identified group inhibitory candidates substantially diminished binding recombinant human monocytic thp cells best blockers ilp ilp ilp inhibited driven expansion producing primary human cells thus novel binders represent unique targeted probes useful epitope mapping studies could used designing novel targeted anti inflammatory biologics
background children living addicted parents risk intentionally unintentionally poisoning present study aimed evaluate effect parental addiction unintentional childhood poisoning materials methods totally admitted children poisoning loghman hospital tehran iran referral center recruited march july cases matched controls age within caliper six months gender date hospital attendance tehran iran parents interviewed using objective checklist risk factors childhood poisoning conditional logistic regression within group varying weights used adjust measured confounders vary weights within matched set defined inverse probability weighting ipw results sixty two cases poisoned methadone odds ratio confidence interval addicted parents poisoned children compared controls three scenarios ordinary stabilized weighted stabilized weighted conditional regression logistic ors respectively conclusion results indicate child abuse neglect linked parental substance abuse education preventive interventions safe storage methadone store poisoning product reach sight children necessary substance abusing families
objectivespharmacists increasingly providing specialized services however process exists specialist certification canada aim study determine extent canadian community pharmacists support development certification system specialization methodsthis study utilized cross sectional online survey licensed canadian pharmacists identified member databases national regional pharmacy associations questionnaire developed french english distributed via email behalf researchers multiple pharmacy organizations january multivariate logistic regressions conducted identify sub groups respondents supported creation certification system supported mandatory certification key findingsa total responses received many respondents practising specialists commonly reported specialty areas diabetes smoking cessation geriatrics almost supported creation canadian certification process felt certification mandatory respondents believed primary benefit certification system greater public confidence pharmacist specialist skills also felt important factor development system create national definitions specialty practice main barrier lack reimbursement specialty services canada conclusionsthe majority canadian community pharmacist respondents support creation certification process pharmacist specialization future study required confirm finding larger sample determine optimal model financial feasibility national system canada
paper presents digital hardware implementation real time simulator multiphase drive using field programmable gate array fpga device simulator developed modular hierarchical design using high speed integrated circuit hardware description language vhdl hence simulator flexible portable state space representation model suitable fpga implementations proposed dual three phase induction machine dtpim simulator also models two level pulse insulated gate bipolar transistor igbt based voltage source converter vsc pulse width modulation scheme measurement system real time simulation outputs stator currents rotor speed validated steady state transient conditions using reference experimental test bench based dtpim rated power accuracy proposed digital hardware implementation evaluated according simulation experimental results finally statistical performance parameters provided analyze efficiency proposed dtpim hardware implementation method
background physiotherapists occupationally elevated risk dermatoses one aim skin care seminars specific professional groupsin individual prevention programme germany ensure appropriate use safety measures patient treatment initially physiotherapists often think skeptically use gloves patients acceptance protective measure objective study assess practicality glove use physiotherapy qualitative investigation customer acceptance massage quantitative investigation methods structured problem focused interviews glove usage held skin diseased physiotherapists masseurs skin care seminars data evaluated inductively using mayring qualitative content analysis clients acceptance tested controlled randomized three setting study subjects received back massage evaluated quality aspects massage questionnaire physiotherapist wearing either gloves pvc gloves made nitrile rubber gloves non inferiority test used test group differences result majority participating physiotherapists considered use protective gloves practical useful measure however occasional problems everyday practice special therapy methods reported analysis questionnaires response rate quality aspects willingness pay regarding client acceptancein massage without gloves showed non inferiority result massages gloves conclusion convincing individual physiotherapists benefits wearing gloves crucial implementation preventive measure improbable patients would refuse services therapists wear gloves treatments consequently usage gloves unlikely result loss practice custom
paper presents issues concerning realization paradigm sustainable design achitectural design offices special attention given relevant technical formal functional solutions domain interior architects creating built environments adequate indoor quality substantial reduction negative impact natural environment presented sustainable architectural interiors completed last decade gained cerificates established independent scientific institutions assuring accordance exigencies rating systems paper analyzes formal methods proper space planning assure high indoor environment quality parameters end users office interiors terms optimum daylighyting workstations recreational areas well workers visual contact natural valuable surroundings requirements satisfactorily met properly shaped inner space elements including partitions ceilings space dividing structures well rational effective use finishing building materials technical technological devices incorporated inner space mentioned paper supposed essential complement design methods assuring proper daylight transmission distribution workspaces discussed examples indicate necessity collaboration interior architects professionals consultants green building accredited consultants whose design contributions accepted respected integrated interior design process assured fulfilment imperatives sustainable architectural design interiors
term crowdsourcing initially introduced describe emerging distributed problem solving model online workers since widely studied practiced support software engineering paper provide comprehensive survey use crowdsourcing software engineering seeking cover literature topic first review definitions crowdsourcing derive definition crowdsourcing software engineering together taxonomy summarise industrial crowdsourcing practice software engineering corresponding case studies analyse software engineering domains tasks applications crowdsourcing platforms stakeholders involved realising crowdsourced software engineering solutions conclude exposing trends open issues opportunities future research crowdsourced software engineering elsevier inc rights reserved
psychophysiological study first examine relationship emotional tears emotional piloerection goosebumps although phenomena related peak states moved details temporal occurrence associated levels physiological arousal remained unknown study used emotionally powerful film scenes self selected participants findings show even within peak moments emotional arousal gradation intensity possible overlap tears goosebumps signifies maximal climax within peak moments side stimulus found displays prosocial behavior play crucial role elicitation tears goosebumps finally based results formal film analysis tears eliciting clips provided participants compared randomly extracted equally long control clips films show technical artistic making clips optimized display social interaction emotional expressions
project management presents management coordination human material resources throughout life project using modern techniques management achievement predetermined objectives particular scope costs time quality satisfaction projects stakeholders construction project unique summary activities resulted product meeting required quality parameters limited time costs parameters managed carefully planning wide range plans result construction planning plans allow effectively manage achievement planned construction parameters time costs quality important construction project management also plans field safety construction equipment measures eliminating impact winter season construction part construction management documentation effective planning management construction process plans currently necessary use sophisticated ict tools paper presents results longitudinal research focused opinion construction companies slovakia related approaches processing important plans management construction projects survey repeated therefore possible examine trends field plans processing using construction management aim research find trend processing construction management documentation authors published elsevier ltd
enhanced inflammation associated alzheimer disease diseases lewy body pathology parkinson disease dementia lewy bodies dlb one issue whether amyloid tangle pathology features alpha synuclein pathology similar different effects brain inflammation aim study examine certain features inflammation changed brains increasing pathology assess measured levels anti inflammatory protein pro inflammatory protein intercellular adhesion molecule icam cingulate temporal cortex total cases classified according unified staging system disorders changes icam levels correlate pathology pathology negatively correlated density neurofibrillary tangles phosphorylated tau amyloid plaque density icam positively correlated pathology measures double immunohistochemistry phosphorylated alpha synuclein markers microglia showed limited association microglia pathology microglia strongly associated amyloid plaques phosphorylated tau results suggest different features inflammatory pathology diseases associated abnormal alpha synuclein compared elsevier inc rights reserved
lengthy tio nanostructures exhibiting improved physicochemical properties recently investigated many useful applications context elongated tio nanowires tnw length diameter prepared photodeposited onto tnw enhanced photo degradation propiconazole fungicide visible light irradiation phase composition tnw anatase rutile almost similar commercially available tio anatase rutile tem analysis reveals uniform dispersion spherical nanoparticles deposits entire tnw surface specific surface area tnw notably higher tio reduced slightly loading tnw exhibited increased relaxation time photoexcited pairs compared tio due elongated structure loading improves charge separation efficiency complete photodecomposition propiconazole bare loaded tnw light irradiation formation various intermediate products monitored hplc analysis revealed loaded tnw always exhibited times higher photocatalytic activity mostly used tio anatase phase larger specific surface area higher lifetime excited charge species loading enhanced visible light absorption capacity due surface plasmon interaction elsevier ltd rights reserved
background house dust mite species dermatophagoides farinae releases allergens cause allergies asthma worldwide study sought clone express full length cdna encoding group allergen farinae der methods published sequence der used design primers pcr race obtain full length cdna encoding der removal signal peptide sequence der sub cloned plasmid pet plasmid transformed escherichia coli cells expression recombinant protein purified nickel affinity chromatography identified sds page western blotting dot blotting maldi tof tested elisa ige reactivity sera children asthma bioinformatics analyses used identify features der results pcr race race full length sequence der generated confirmed nucleotide sequencing mature der expressed successfully coli identified sds page recombinant allergen purified chromatography confirmed sds page western blotting dot blotting maldi tof sera mite allergic patients reacted purified recombinant der conclusions successful production recombinant der protein revealed importance der mite allergy provides foundation study allergen diagnosis treatment symptoms wiley periodicals inc
current investigation evaluated whether cognitive processes characteristic social information processing model predicted parent child aggression pca risk independent personal vulnerabilities resiliencies study utilized multimethod approach including analog tasks diverse sample primiparous expectant mothers partners factors considered study included pca approval attitudes empathy reactivity negative child attributions compliance expectations knowledge non physical discipline alternatives additionally vulnerabilities included psychopathology symptoms domestic violence victimization substance use whereas resiliencies included perceived social support partner relationship satisfaction coping efficacy mothers fathers findings supported role greater approval pca attitudes lower empathy overreactivity negative attributions higher compliance expectations relation elevated risk pca moreover personal vulnerabilities resiliencies related pca risk mothers however fathers mothers differed nature relationships respect vulnerabilities well aspects empathy pca approval attitudes findings provide evidence commonalities many factors investigated mothers fathers notable distinctions results discussed terms findings could inform prevention programs
aims media reports related people suffering mental illness appear deal prevalently acts violence crimes present study focused newspaper reports relating homicides suicide acts violence attempt ascertain whether different pattern emerged italian newspapers describing deeds committed mentally ill materials methods articles published six month period two main national two main regional newspapers relating homicides suicides acts violence selected comparison reports regarding events attributed mentally ill people performed according quantitative parameters results articles considered regarded homicides suicides attempted suicides homicides suicides remaining regarded acts violence significantly higher number words accompanying photos stigmatizing language used reporting deeds attributed mentally ill people conclusion excessive emphasis deeds related psychopathological condition still emerged media reports almost though acts violence committed mentally insane viewed different light findings support hypothesis media portrayal mirrors enduring stereotype diversity mentally ill
study explores whether object relations functioning improves course psychodynamic psychotherapy whether improvement related symptom decrease well therapist technique sample consisted outpatients engaged short term psychodynamic psychotherapy university based psychological service clinic functioning assessed pre post treatment independent raters using social cognition object relations scale session patient relational narratives comparative psychotherapy process scale used assess therapist activity psychotherapy techniques early treatment independent clinical ratings global psychotherapy techniques conducted rater agreement found excellent range regarding results global overall quality level interpersonal functioning significantly improved large effect size psychodynamic therapy change global functioning significantly positively related incidence psychodynamic techniques early sessions number psychotherapy sessions attended patient self reported reliable change symptomatology reliable change global significantly related well multilevel model analyses confirmed pairwise correlations accounting therapist effects variety process outcome measures number sessions attended initial levels psychiatric symptoms employment therapeutic techniques well overall functioning outcome limitations present study future research directions implications clinical practice also discussed copyright john wiley sons ltd
present paper new approach arabic sign language arsl alphabet recognition using hand gesture analysis analysis consists extracting histogram oriented gradient hog features hand image using generate svm models used recognize arsl alphabet real time hand gesture using microsoft kinect camera approach involves three steps hand detection localization using microsoft kinect camera hand segmentation iii feature extraction using arabic alphabet recognition one input image first obtained using depth sensor apply method based hand anatomy segment hand eliminate errors pixels approach invariant scale rotation translation hand experimental results show effectiveness new approach experiment revealed proposed arsl system able recognize arsl accuracy
automation analog integrated circuit design process important optimization contradictions study benefits multi objective evolutionary algorithms presented two stage operational amplifier design using harmony search algorithm hsa non dominated sorting genetic algorithm nsga hsa new kind multi objective evolutionary algorithm inspired musicians looking best combination musical sounds different instruments produces pleasing sound nsga advanced version genetic algorithm combines current parents child population select new parents kinds design automation tools required analog circuit design several contradictions design work transistor sizes effects constraints indirectly automatically synthesized hsa nsga
water hydroxyl detected remotely lunar surface originates several sources comets exogenous debris solar wind implantation iii lunar interior sources interesting right distinguishing among critical testing hypotheses origin evolution moon solar system existing spacecraft observations high enough spectral resolution uniquely characterize bonding energies hydroxyl molecules detected nevertheless spatial distribution associations specific lunar lithologies provide insight origin lunar hydrous materials global distribution detected using infrared spectroscopic measurements orbit examined particular focus regional geological features exhibit absorption band strengths differ immediate surroundings article part themed issue origin history role water evolution inner solar system
deployment smart grids renewable energy dispatch centers motivates development forecasting techniques take advantage near real time measurements collected geographically distributed sensors paper describes forecasting methodology explores set different sparse structures vector autoregression var model using least absolute shrinkage selection operator lasso framework alternating direction method multipliers applied fit different lasso var variants create scalable forecasting method supported parallel computing fast convergence used system operators renewable power plant operators test case wind power plants used show improvement forecasting skill exploring distributed sparse structures proposed solution outperformed conventional autoregressive vector autoregressive models well sparse var model state art copyright john wiley sons ltd
probing interactions biological systems molecular level great importance fundamental biology diagnosis drug discovery rational bioassay design lithographically integrating individual point scattering sites electrical circuits capable realizing real time label free biodetection influenza viruses single molecule sensitivity high selectivity using silicon nanowires local reporters combination microfluidics nanocircuit based architecture complementary conventional optical techniques advantages bleaching problems fluorescent labeling advantages offer promising platform exploring dynamics stochastic processes biological systems gaining information genomics proteomics improve accurate molecular even point care clinical diagnosis
improvement blast resistance supporting elements application protective cover main goal paper developed sandwich panel effective blast protection however solutions sensitive design parameters including thickness components stiffness strength materials panel lay therefore numerical optimization based computational mechanics implemented reduce deformations protected supporting structure caused blast loading optimization based simplified model consisted laminate parts metallic foam steel external cover beam pillar model automatically generated depending optimization variables using developed pre processor script delamination process also taken consideration dynamic response structural components subjected blast wave different cases analysed obtained results clearly showed application optimized blast panel reduces plastic deformation structure significantly increases blast resistance moreover obtained parameters verified using fully model protective panel pillar fsi interface elsevier ltd rights reserved
background although wide range health system performance indicators commonly reported little effort establish relevance objectives health systems actually pursue objective aim study identify explore better understand health policy makers views regarding objectives outcomes health systems prioritized underlying processes yield inform development health system efficiency measures methods descriptive qualitative methodology employed using key informant interviews current former senior health ministry officials canadian provinces territories key findings health ministries clearly stated objectives health systems focused achievement health system delivery population health goals increasingly public patient financial accountability acute care objectives routinely prioritized population health objectives viewed resulting challenges associated difficult trade decisions shaped organized interests media rather explicit evidence based processes conclusion study provides insights beyond publicly available documents explore processes underlie simple statements health system objectives findings suggest despite respondents giving priority improving individual population health commonly portrayed ideal objective realistic one understanding lies behind statements health systems striving offer robust avenue increasing uptake future studies health system performance elsevier ireland ltd rights reserved
file buffer caching plays important role narrow wide speed gap main memory secondary storage however data loss inconsistency may occur system crashes updated data buffer cache flushed storage thus operating systems adopt daemon periodically flushes dirty data secondary storage periodic flush degrades caching efficiency seriously write requests lead direct storage accesses show periodic flush accounts percent total write traffic storage remove inefficiency paper presents new buffer cache architecture adopts small amount non volatile memory maintain modified data novel buffer cache architecture removes almost storage accesses due periodic flush operations without loss reliability also improves buffer cache performance space efficient management techniques delta write fragment grouping experimental results show proposed buffer cache reduces storage write traffic percent also improves throughput percent average
paper presents controller design implementation high precision degree freedom dof magnetically levitated maglev positioner high precision positioning system consists novel concentrated field magnet matrix triangular single moving part carries three phase permanent magnet linear levitation motor armatures since single levitated moving part namely platen generates required fine coarse motions positioning system reliable low cost three planar levitation motors based lorentz force law generate vertical force levitate triangular platen control platen position orientation horizontal plane dof motions controlled magnetic forces platen regarded pure mass system spring damping coefficients neglected except vertical directions single input single output siso digital lead lag controllers designed implemented digital signal processor dsp dof fully magnetically levitated positioner total mass currently exhibits travel range positioner highly suitable semiconductor manufacturing applications wafer steppers several experimental motion profiles presented demonstrate maglev stage capability accurately tracking planar paths
cloud computing paradigm provides scalable resources service internet vulnerabilities cloud infrastructure readily exploited adversary class therefore providing desired level assurance stakeholders safeguarding data sensitive otherwise stored cloud utmost importance addition protecting cloud adversarial attacks diverse types intents understated economic denial sustainability edos attack considered one concerns stalled many organizations migrating operations data cloud edos attack targets financial component service provider work propose novel reactive approach based rate limit technique low overhead detect mitigate edos attacks cloud based services reactive scheme limited access permission cloud services granted user experiments conducted laboratory cloud setup evaluate performance proposed mitigation technique results obtained show proposed approach able detect prevent attack low cost overhead elsevier rights reserved
objective study assess magnitude predictors first line antiretroviral treatment failure among hiv infected children retrospective cohort study conducted january december pediatric patients years old took least months art fiche kuyu hospitals oromia region ethiopia included study collected data entered analyzed using spss version multi variable logistic regression employed identify predictors treatment failure data children analyzed majority children males mean age years based two criteria overall art failure found clinical immunologic failures mean time detection treatment failure months children age years aor protective toward treatment failure lost follow aor died aor transferred aor suboptimal adherence art aor baseline count cells aor advanced clinical stage aor found predictors treatment failure study revealed treatment failure high mean time develop treatment failure short predictors treatment failure suboptimal adherence lost follow transferred initial count cells initial stages hand age years protective developing treatment failure compared age category
among end stage renal disease patients maintained hemodialysis anemia managed primarily erythropoiesis stimulating agents esas intravenous iron following concerns cardiovascular safety esas changes reimbursement policies medicare esrd program use iron increased iron supplementation promotes hemoglobin production reduces esa requirements yet exists relatively little evidence long term safety iron supplementation hemodialysis patients labile iron induce oxidative stress also essential bacterial growth leading concerns iron use risk events infections hemodialysis patients existing randomized controlled trials provide little evidence safety due insufficient power short follow recent observational studies inconsistent associated iron exposure increased risk infections events given widespread use potential safety concerns related iron well designed large prospective studies needed assess identify optimal strategies iron administration maximize benefits avoiding potential risks
objective psoriasis considered systemic disorder lipocalin might link psoriasis comorbidities aim study investigate associations serum lipocalin levels disease activity markers inflammation metabolic disturbances changes topical treatment psoriatic patients methods thirty seven individuals active plaque type psoriasis healthy controls recruited blood samples collected days therapy serum lipocalin concentrations examined enzyme linked immunosorbent assay results correlated psoriasis area severity index pasi body mass index bmi inflammatory biochemical markers lipid profile effectiveness topical treatment results lipocalin serum levels significantly increased psoriatic patients comparison controls significant correlations indicators inflammation bmi pasi noted statistical association lipocalin low density lipoprotein cholesterol shown topical treatment serum lipocalin level significantly change still remaining higher controls despite clinical improvement conclusions lipocalin might marker psoriasis convey cardiovascular metabolic risk psoriatic patients may reliable indicator inflammation severity psoriasis efficacy antipsoriatic treatment
fluid implicit particle method flip liquid simulations uses particles reduce numerical dissipation provide important visual cues events like complex splashes small scale features near liquid surface unfortunately flip simulations computationally expensive require dense sampling particles fill entire liquid volume furthermore vast majority flip particles contribute nothing fluid visual appearance especially larger volumes liquid present method uses flip particles within narrow band liquid surface efficiently representing remaining inner volume regular grid show naive realization idea introduces unstable uncontrollable energy fluctuations propose novel coupling scheme flip particles regular grid overcomes problem method drastically reduces particle count simulation times yielding results nearly indistinguishable regular flip simulations approach easy integrate existing flip implementation
social commerce emerging phenomenon rooted social media web technologies attracted attention many researchers number publications social commerce grown exponentially past years social commerce become significant emerging research area paper first define boundary social commerce research attempt review extant literature area comprehensively systematically based definition study surveyed peer reviewed academic publications social media web related areas following survey publications identified social commerce research latent semantic analysis lsa text mining approach applied summarize current state social commerce research lsa results show three major research themes current social commerce research organization advertisement word mouth theme discusses topics innovation user generated content reputation among others addition identify interesting trends first main trend innovation corporate reputation user generated content remain major research topics although experiencing slight decline second main trend online reviews trust word mouth attracting attention researchers elsevier ltd rights reserved
objectives identification peripheral biomarkers bipolar disorder great importance potential improve diagnosis treatment prognosis recent studies reported lower plasma progranulin levels bipolar individuals compared controls association single nucleotide polymorphisms snps within progranulin gene grn present study investigated effect grn sortilin sort gene variation serum progranulin levels bipolar individuals controls materials methods danish cohort individuals bipolar disorder controls analysed serum progranulin level bipolar controls five snps located within grn two snps near sort gene encoding sortilin progranulin scavenger receptor known affect circulating progranulin levels bipolar controls results observed significant difference serum progranulin level cases controls none analysed snps located within grn close sort associated bipolar disorder crude adjusted adjusted case control status sex age linear regression analyses showed effect snps serum progranulin level however observed mean serum progranulin level cases controls affected differently depending genotypes two snps within grn limitation sample size relatively small detailed information medication polarity disorder available correction multiple testing performed conclusion study suggests potential progranulin biomarker bipolar disorder genotype dependent copyright wolters kluwer health inc rights reserved
full order single parameter searching method method analyzing coupled flutter instability long span bridges proposed based full discretized model structure based proper approximation circular frequency complex modes characteristic equation full order system expressed complex generalized eigenvalue equation contains two variables equation used flutter analysis solving complex generalized eigenvalue problem efficient simultaneous iteration method directly since computation reliable efficient application proposed method flutter problems long span bridges practical moreover flutter analysis performed jiangyin yangtze river suspension bridge main span completed stage illustrate reliability effectiveness proposed method
enhance safety standing pole living work solve problem labor intensity big stability difference enhance efficiency living work vehicle level standardization design manufacture insulating supporting stick according different arrangement conductor trace line writer designed three types insulating supporting stick begun standardized design select material calculate strength materials based mathematical model writer introduces fundamental desire according designing manufacturing insulating supporting stick actualize complexion technical design application complexion insulating supporting stick practice
background hepatitis virus hcv infections increased past decade little known geographic clustering patterns methods used unique analytical approach combining geographic information systems gis spatial epidemiology statistical modeling identify characterize hcv hotspots statistically significant clusters census tracts elevated hcv counts rates compiled sociodemographic hcv surveillance data cases massachusetts census tracts used five step spatial epidemiological approach calculating incremental spatial autocorrelations getis ord statistics identify clusters conducted logistic regression analyses determine factors associated hcv hotspots results identified nine hcv clusters largest boston new bedford fall river worcester springfield multivariable analyses found hcv hotspots independently positively associated percent population hispanic adjusted odds ratio aor confidence interval percent households receiving food stamps aor hcv hotspots independently negatively associated percent population high school graduates higher aor percent population race ethnicity category aor conclusion identified locations hcv clusters concern enhanced hcv prevention treatment care help combat hcv epidemic massachusetts gis spatial epidemiological statistical analyses provided rigorous approach identify hotspot clusters disease inform public health policy intervention targeting studies incorporate spatiotemporal cluster analyses bayesian spatial geostatistical models spatially weighted regression analyses assessment associations hcv clustering built environment needed expand upon combined spatial epidemiological statistical methods
analyze controllability properties class bilinear interconnected systems consisting networks linear systems coupling parameters act control variables characterize system lie algebra resulting bilinear control systems necessary sufficient conditions accessibility derived terms underlying interconnection graph results generalize earlier work brockett controllability bilinear output feedback systems well recent work costello egerstedt control information exchange networks distributed computing
supramolecular interaction nonsteroidal anti inflammatory drug molecules macrocyclic hosts one interesting areas research study interaction indomethacin acemetacin macrocyclic cucurbit uril aqueous medium reported supramolecular interaction drug molecules macrocyclic host studied using steady state absorption fluorescence time resolved fluorescence emission spectroscopy isothermal titration calorimetry modulation spectral features drug molecules addition cucurbit uril indicates interaction takes place drug molecules cucurbitl uril respectively indomethacin acemetacin form complex cucurbit uril binding strength stoichiometry drug molecules cucurbit uril estimated using fluorescence isothermal titration calorimetry measurements respectively driving forces involved complexation drug molecules cucurbitr uril obtained isothermal titration calorimetry measurement study helpful get knowledge modulation photophysical properties studied drugs addition macrocyclic host cucurbit uril changes thermodynamic properties due complexation drug molecules cucurbit uril help understand governing parameters involved complexation study helpful use cucurbit uril potential drug delivery system elsevier rights reserved
background adolescent mothers much higher risk maternal mortality compared mothers aged years newborns born adolescent mothers also likely low birth weight risk long term effects early onset adult diabetes newborns older mothers studies investigated determinants adequate quality maternal child healthcare services pregnant adolescents study conducted gain understanding nurses midwives intentions provide maternal child healthcare family planning services adolescents south africa methods total nurses midwives completed cross sectional survey survey included components demographics knowledge maternal child healthcare mch family planning services attitude towards family planning services subjective norms regarding maternal child healthcare family planning services self efficacy maternal child healthcare family planning services intentions provide maternal child healthcare family planning services adolescents pearson correlation analysis conducted determine association knowledge attitude subjective norms self efficacy intention variables mch services step linear regression analysis conducted mch services predict intentions provide mch services adolescents results self efficacy conduct mch services beta years experience nurse midwife beta associated stronger intentions provide services self efficacy provide services beta associated stronger intentions provide services conclusions self efficacy strong positive association intentions provide mch services moderate association attitude norms need improve strengthen nurses midwives self efficacy conducting mch services order improve quality utilization services adolescents south africa
green building envelopes currently one promising ways provide energy savings buildings contribute urban heat island effect mitigation shadow effect supplied plants significant parameter purpose one way characterize potential shadow effect greenery calculate facade foliar density means leaf area index lai lai commonly used horizontal crops use vertical greenery systems vgs generated dispersion uncertainty previous studies terms methodologies results obtained addition lack data relating influence facade orientation final contribution vertical greenery energy savings observed previous studies study aims establishing common easy way measure lai lick energy savings provided vgs moreover energy savings achieved well influence facade orientation final thermal behaviour two different vgs double skin green facade green wall studied results stated simple quick procedure measure lai order characterize foliar density vgs indirect method based amount light transmitted green screen experimental tests interesting energy savings obtained boston ivy pant specie lai summer period mediterranean continental climate moreover dependence facade orientation confirmed representative contribution whole energy savings east west orientation elsevier ltd rights reserved
proper knowledge noninvasive facial rejuvenation integral practice cosmetic surgeon noninvasive facial rejuvenation divided patient versus physician directed modalities patient directed facial rejuvenation combines use facial products sunscreen moisturizers retinoids alpha hydroxy acids various antioxidants maintain youthful skin rejuvenate damaged skin physicians may recommend often prescribe certain products patients control type facial rejuvenation hand physician directed facial rejuvenation entails modalities require direct physician involvement neuromodulators filler injections laser resurfacing microdermabrasion chemical peels successful integration modalities complete facial regimen established patient satisfaction maximized article first three part series describing noninvasive facial rejuvenation authors focus patient directed facial rejuvenation important however emphasize even patient directed modality physician involvement education guidance integral success
discuss two semi independent calibration techniques used determine inflight radiometric calibration new horizons multi spectral visible imaging camera mvic first calibration technique compares measured number counts observed number well calibrated stars predicted using component level calibration ratio values provides multiplicative factor allows conversation preflight calibration accurate inflight one detector second calibration technique channel wise relative radiometric calibration mvic blue near infrared methane color channels using hubble new horizons observations charon scaling red channel stellar calibration calibration techniques produce similar results better agreement providing strong validation techniques used since stellar calibration described performed without color target field view covers mvic detectors calibration used provide radiometric keyword values delivered new horizons project planetary data system pds keyword values allow observation converted counts physical units description keyword values generated included finally mitigation techniques adopted gain drift observed near infrared detector one panchromatic framing cameras also discussed elsevier inc rights reserved
evaluate feasibility performing comprehensive cardiac magnetic resonance cmr guided electrophysiological interventions porcine model encompassing left atrial access introduction two femoral sheaths swine transferred scanner three dimensional whole heart sequence acquired followed segmentation visualization heart chambers using image guidance platform two conditional catheters inserted interventional protocol consisted intubation coronary sinus activation mapping transseptal left atrial access generation ablation lesions eventually ablation atrioventricular node visualization catheter tip active tracking used catheter positions confirmed passive real time imaging total procedure time minutes protocol could completed swine two swine died ablation induced ventricular fibrillation catheters could visualized navigated active tracking almost exclusively position catheter tips visualized active tracking could reliably confirmed passive catheter imaging comprehensive cmr guided interventions including left atrial access feasible swine using active catheter tracking aeuro cent comprehensive cmr guided electrophysiological interventions including access conducted swine aeuro cent active catheter tracking allows efficient catheter navigation also transseptal approach aeuro cent conditional tools needed facilitate left atrial interventions humans
paper optimization method wavelet neural network structure damage identification established suspension bridge used research object firstly wavelet coefficients modulus maxima obtained wavelet transform determine location structural damage connection weights thresholds neural network optimized particle swarm optimization optimized neural network constructed determine degree damage bridge validity method verified numerical simulation multi span suspension bridge
idiopathic pulmonary fibrosis ipf common interstitial pneumonia aggressive interstitial lung disease usually ipf confirmed histopathological pattern typical interstitial pneumonia requires integrated multidisciplinary approach pulmonologists radiologists pathologists however diagnoses performed advanced stage ipf present pathway based detection requires investigation performed early stage disease aim present study find effective method diagnosing ipf early stage microarray data fore geod downloaded arrayexpress database human pathways downloaded kyoto encyclopedia genes genomes kegg pathway database individual pathway based method diagnose ipf early stage introduced pathway statistics analyzed individualized pathway aberrance score values obtained different methods including wilcoxon test linear models microarray data limma test attract methods generating three pathway groups support vector machines svm used identify best group diagnosing ipf early stage differential pathways wilcoxon based kegg pathway group limma based kegg pathway group seven attract based kegg pathway group pathway statistics differential pathways three groups analyzed linear svm results demonstrated wilcoxon based kegg pathway group performed best diagnosing ipf
twitter spam become critical problem nowadays recent works focus applying machine learning techniques twitter spam detection make use statistical features tweets labeled tweets data set however observe statistical properties spam tweets vary time thus performance existing machine learning based classifiers decreases issue referred twitter spam drift order tackle problem first carry deep analysis statistical features one million spam tweets one million non spam tweets propose novel lfun scheme proposed scheme discover changed spam tweets unlabeled tweets incorporate classifier training process number experiments performed evaluate proposed scheme results show proposed lfun scheme significantly improve spam detection accuracy real world scenarios
existing methods solving two phase flow problems porous media take physically feasible saturation fractions account often destroys numerical accuracy physical interpretability simulation calculate solution without loss basic requirement introduce variational inequality formulation saturation equilibrium box inequality constraint use conservative finite element method spatial discretization backward differentiation formula adaptive time stepping temporal integration resulting variational inequality system time step solved using semismooth newton algorithm accelerate newton convergence improve robustness employ family adaptive nonlinear elimination methods nonlinear preconditioner numerical results presented demonstrate robustness efficiency proposed algorithm comparison also included show superiority proposed fully implicit approach classical implicit pressure explicit saturation impes method terms time step size total execution time measured parallel computer elsevier inc rights reserved
construction project management predominantly focuses meeting technical specifications schedules budgets whereas service quality commonly neglected therefore managing process end user perspective provides considerable potential improving project success customer experience management cem guides service providers make service easy valuable customer possible paper explores potential cem office fit project finland presents process model support future projects cem process collaboratively designed construction management consultant finnish governmental property owner work involved series workshops interviews pilot project results show cem requires multi functional collaboration new management practices cultural shift construction management future projects created process model may significantly ease efforts required plan end user experience management authors published elsevier
school anxiety appears related self esteem self handicapping strategies study aims identifying children atypical levels anxiety examining relationship self esteem school use self handicapping strategies sample included pupils years attending third grade primary school divided three groups pupils low anxiety average anxiety high anxiety children administered scale evaluation anxiety safa tma multidimensional test self esteem self handicapping scale children whole results demonstrate nearly normative distribution school anxiety nonclinical sample pupils average level school anxiety showed higher level self esteem engaged self handicapping strategies developmental perspective suggests importance preventive research order identify risk factors subsequent anxiety disorders early age
background smokers increasingly seek alternative interventions assist cessation reduction efforts mindfulness meditation facilitates detached observation paying attention present moment openness curiosity acceptance recently studied smoking cessation intervention aims review synthesizes randomized controlled trials rcts mindfulness meditation interventions smoking cessation methods five electronic databases searched inception october identify english language rcts evaluating efficacy safety interventions smoking cessation reduction decrease nicotine cravings two independent reviewers screened literature using predetermined eligibility criteria abstracted study level information assessed quality included studies meta analyses used hartung knappsidik jonlonan method random effects models quality evidence assessed using grade approach findings ten rcts interventions tobacco use met inclusion criteria intervention duration intensity comparison conditions varied considerably studies used diverse comparators american lung association freedom smoking ffs program quitline counseling interactive learning treatment usual tau one rct rated good quality reported power calculations indicating sufficient statistical power publication bias detected overall mindfulness meditation significant effects abstinence cigarettes per day relative comparator groups small number studies heterogeneity interventions comparators outcomes precluded detecting systematic differences adjunctive monotherapy interventions serious adverse events reported conclusions differ significantly comparator interventions effects tobacco use low quality evidence variability study design among small number existing studies publication bias suggest additional high quality adequately powered rcts conducted elsevier ltd rights reserved
performance photovoltaic panels depends many factors one factor involves light reception angles panels intensity received solar radiation sun earth affected significantly diurnal seasonal movement earth maximum output panels achieved panels perpendicular sun rays research empirical financial assessment benefit using dual axis sun tracker versus fixed flat position well comparison performance two panels settings experiment conducted using panels manual dual axis sun tracker data acquisition system collected stored experimental data significant improvement output noticed tracked panel overall average improvement entire data collection time interval financial assessment performed based energy market rate texas average price operative expenses dual axis sun trackers breakeven point dual axis sun tracking system found never years panel configurations respectively system
purpose study determine environmental impacts associated deep energy efficiency refurbishment using life cycle assessment prototypical refurbished model office building located auckland new zealand used case study refurbishment included major changes building envelope additional insulation modified wall window ratio solar shading well technical replacement lighting hvac system study included identification environmental hot spots deep energy refurbishment consideration effect different electricity mixes new zealand total environmental impact refurbished building compared refurbished existing building different operation periods environmental payback period calculated impact category results study indicate deep energy refurbishment associated significant environmental impacts mainly due use energy intensive construction materials however refurbishment yields net reductions impact categories building longer operational period environmental impacts building operation mainly associated new zealand electricity generated coal future scenarios new zealand electricity mix reduced share electricity generated coal environmental benefits avoided electricity consumption also reduced study concludes measures promote energy efficiency refurbishment office buildings significant proportion operational energy provided renewable energy sources carefully considered may reduce overall environmental impacts elsevier ltd rights reserved
ion useful process broadening mental horizons integrating new experiences communicating information others much attention directed identifying causes consequences abstraction across subdisciplines psychology despite attention integrative review methods used studying abstraction missing literature current article aims fill gap several ways first highlight different ways abstraction defined literature suggest integrative definition second provide tour different ways abstraction manipulated measured years finally highlight considerations researchers choosing methods research
amylin pancreatic cell derived peptide hormone forms inclusions brain microvessels patients dementia diagnosed type diabetes alzheimer disease cellular localization inclusions consequences thereof yet known using immunohistochemical staining hippocampus parahippocampal cortex patients alzheimer disease non demented controls show amylin cell inclusions found pericytes number amylin cell inclusions differ patients alzheimer disease controls amylin containing pericytes displayed nuclear changes associated cell death reduced expression pericyte marker neuron glial antigen impact amylin pericyte viability demonstrated invitro studies showed pericyte death increased presence fibril oligomer amylin furthermore oligomer amylin increased caspase activity reduced lysate neuron glial antigen levels impaired autophagy findings contribute increased understanding aggregated amylin affects brain vasculature highlight amylin potential factor involved microvascular pathology dementia progression
substantial resources devoted mitigating asset gender gap developing country agriculture efforts taken understand role women decision making farm operations recommendations best practices eliciting information women roles emphasized importance sex disaggregated data collection analysis collection sex disaggregated data straightforward careful attention context needed ecuador highlands chemical use agriculture widespread outreach training programs reduce use essential programs target appropriate decision makers paper presents results field experiment conducted ecuador highlands responding farm households randomly assigned one three treatment groups male respondent female respondent iii adult male female respondents interviewed separately knowledge would also interviewed assess whether treatment assignment affects responses questions decision making responsibility agricultural activities perceptions household decision making responsible agricultural activities vary substantially type respondent men likely claim sole responsibility women likely claim responsibility decisions jointly made households man woman interviewed separately found stark differences responses responsibilities men claiming sole responsibility higher rates interviewing members led less divergence responses large differences perceptions responsibilities remain interviewed best interviewing practices depend type information needed precise quantification gender roles complex methods may necessary qualitative information sufficient single member interviews may sufficient elsevier ltd rights reserved
providing educative help home means professionals enter intimacy families share daily tasks often long time family support workers spend many hours alongside parents helping domestic parenting tasks paper reports findings ethnographic study researcher notes gathers personal accounts relating material non material exchanges professionals parents analyses various forms exchanges families family support workers permitted tolerated excluded employers shows informal side professionals working parents home
limited power budgets sensor networks necessitate level network pre processing reduce communication overhead low power consumption analog signal processing asp well suited task however quick adoption technology restrained fact asp implementation requires priori knowledge application space solution challenge enable run time reconfiguration use field programmable analog array fpaa way reconfigurable digital systems allow system designers change infrastructure digital blocks fpaa allows application developer change infrastructure even tune asp blocks without circuit level expertise demonstrate fpaa used facilitate use asp reduce power consumption allow run time reconfigurability maximize asp impact
objective investigate extent reasons contributing discrepancies receiving dsm clinical diagnosis bipolar disorder borderline personality disorder bpd method interviewed participants previously receiving bpd diagnosis studying met dsm clinical criteria one conditions compared numbers participants allocated three diagnostic categories according rater strategy calculate concordance rates determine reasons discordance results rates assignment bpd comorbid bpd varied according diagnostic strategy concordance rates reduced disorder duration criteria relaxed discordance mainly arising clinical allocation disorder dsm assigned unipolar depression rates bpd allocation varied marginally discordance mostly arising clinically diagnosed receiving comorbid bpd dsm diagnosis finally dsm overestimated comorbidity compared clinician diagnoses central importance imposing dsm duration criteria increase prevalence misdiagnosing bpd finding variance literature conclusion rates reasons discordance clinical dsmdiagnosis detailed assist clinical decision making
traffic jam one hardest problems crowded cities needs solved study effect minimum speed limit signs addition maximum speed signs locations traffic flow examined using cellular automata urban traffic modeled two dimensional model includes traffic signs traffic lights kinds vehicles automobiles vans buses metro buses often encountered traffic
purpose objective study compare quality care provided minnesota senior health options msho special program designed serve dually eligible older persons care provided controls received fee service medicare medicaid managed care design methods two control groups used one drawn nonenrollees living area control another comparable individuals living another urban area program available control cohorts living community nursing homes included quality measures groups included mortality rates preventable hospital admissions preventable emergency room visits community group nursing home admission rates also tracked nursing home residents quality measures included quality indicators derived minimum data set results differences mortality rates either cohort msho fewer short stay nursing home admissions difference stays days longer msho community nursing home residents fewer preventable hospital visits compared control major differences nursing home quality indicator rates implications cost changing model care dual eligibles mixture fee service managed care merged managed care approach readily justified improvements quality observed
work deals arch defined global coordinates shows procedure followed obtain formulation differential system curved beam procedure consists mainly applying differential system besides habitual assumptions strength materials simplifications geometric conditions planar curves resulting model includes analysis arches variable section action force moment rotation displacement plane successive integration equations system permits obtaining solution represents structural behavior arch type support applying boundary conditions problem obtained directly exact analytical solution examples calculus parabolic arches given show practical viability procedure followed results presented graphs tables comparable obtained literature method suitable educational purposes elsevier ltd rights reserved
concurso ingenieria control cic engineering control challenge student challenge organized comite espanol automatica cea spanish committee automation spain set educational motivational tool control engineering students although originally devised spanish pupils several non spanish teams ended participating two editions article describes details challenge organization shows well impressions obtained polls testimonials participants
electrochemical impedance spectroscopy eis great value corrosion studies sensitive transient changes occur metal electrolyte interface useful way link results electrochemical impedance spectroscopy corrosion phenomena simulating equivalent circuits equivalent circuit models attractive relative simplicity enabling monitoring electrochemical systems complex physical mechanism paper stochastic algorithm differential evolution proposed fit equivalent circuit eis results wide potential range eis often limited corrosion potential despite widely used greatly hinders analysis regarding effect applied potential strongly affects interface shown example polarization curves moreover data eis values used proposed scheme allowing best fit model parameters approach compared standard simplex square residual minimization eis data order manage large amount generated data eis mapper software package also plots diagrams potential used fit equivalent circuit multiple diagrams furthermore eis mapper also computed simulations results impedance diagrams stainless steel nacl medium degrees obtained steps respective values fitted parameters equivalent circuit reported present approach conveys new insight use electrochemical impedance bridges gap polarization curves equivalent electrical circuits elsevier ltd rights reserved
depression mixed features poorly understood especially pediatric samples study compares symptoms correlates depressed adolescent inpatients mixed features inpatients bipolar disorder major depression adolescents administered diagnostic interviews self reports categorized depression mixed features mxd consensus bipolar depression demographic morbidity information collected via chart reviews mxd adolescents evidenced elevated mania related symptoms compared adolescents mxd adolescents elevated unusually energetic symptoms increases six additional category mania related symptoms compared adolescents mxd adolescents met criteria comorbid disorders reported elevated suicidality anger trauma symptoms compared adolescents overall mxd adolescents evidenced elevated symptomatology compared groups suggesting mixed depression may represent unique constellation symptoms meriting investigation
introduction depressive symptoms common patients parkinson disease significant impact quality life methods present study analyzed correlations time changes depressive symptoms gray matter parameters cortical thickness subcortical volumes non demented patients results significant correlation observed increased scores depression time lower cortical thickness time right temporo parietal junction right occipital medial region right dorsolateral prefrontal cortex right posterior cingulate region left middle temporal well left supplementary motor area furthermore presence depressive symptoms baseline predicted increased cortical thinning time left middle temporal left anterior cingulate right posterior cingulate right parahippocampal cortices finally statistically significant negative correlation revealed thalamus volume changes time change depressive symptoms scores analyzed subcortical structures reveal significant correlations conclusion results suggest depressive symptoms patients associated gray matter cortical thinning thalamus volume shrinkage time higher scores depressive symptoms baseline correlate higher rate cortical thinning longitudinally present study highlights importance addressing depressive symptoms patients early disease elsevier inc rights reserved
background amiodarone amio many years effectively used control ventricular rate atrial fibrillation convert sinus rhythm however due delayed onset action ranolazine ran new antianginal agent atrial selective electrophysiologic properties recently attempted add therapy amio facilitate conversion methods establish role combination therapy enrolled consecutive patients years male recent onset hour duration eligible pharmacologic cardioversion patients randomized intravenous amio loading dose hour followed amio plus single oral dose ran results mean left atrial diameter significantly differ groups amio amio ran amio ran group compared amio group showed significantly shorter time conversion hours hours higher conversion rate hours left ventricular ejection fraction markedly vary two groups ranged within moderately reduced values serious clinically evident adverse effects observed patients receiving either amio combination treatment conclusions data demonstrate faster sinus rhythm restoration enhanced conversion rate amio plus ran patients preserved ejection fraction left atrial size implicating synergistic effect two agents
introduction dysregulation janus kinase jak signal transducer activator transcription stat pathway described myelofibrosis currently unmet need agents benefit jak inhibition yet also safe effective patients thrombocytopenia areas covered discuss various preclinical clinical studies describing pacritinib selective jak flt inhibitor far shown promising results without significant thrombocytopenia pubmed search using keywords pacritinib myelofibrosis conducted published abstracts recent national international meetings also reviewed unpublished data expert commentary currently pacritinib hold food drugs administration would imperative understand treatment related toxicity would limit use safe path found agent could significant benefit various settings based data far
objective australia social gradient chronic disease never prominent current times uptake preventive health messages appears lower discrete population groups efforts frame health promotion addressing behavior change empowerment engaged community groups disadvantaged neighborhoods translate published preventive guidelines easy understand messages general population method research team established partnerships older aged community groups located disadvantaged neighborhoods determined cross referencing addresses australian bureau statistics translate guidelines regarding osteoporosis prevention results developed oversized jigsaw puzzle used translate recommended osteoporosis prevention guidelines discussion successful participatory partnerships researchers health promotion professionals community groups disadvantaged neighborhoods build capacity researchers undertake future participatory processes also make best use expert knowledge held specific communities
growing evidence indicates gratefulness gratitude important well happiness yet research date hindered lack conceptual clarity nature constructs present paper reviews existing literature argues distinction gratefulness gratitude gratefulness gratitude types appreciative functioning involve benefit appraisals latter concerns perceived agency set triggers moderating factors motivation behavioural processes involved gratefulness gratitude outlined differences highlighted vantage argued appreciative functioning adequately represented complex dynamic system involves plurality interacting processes processes common gratefulness gratitude unique proposed conceptualisation appreciative functioning spans aspects attention cognition emotion motivation social behaviour integrating diverse approaches gratefulness gratitude taken literature suggested grateful dispositions understood characteristic self reinforcing patterns complex system functions paper also highlights need measure gratitude gratefulness independently qualitatively quantitatively determine unique contribution two constructs well
researchers vigorously debating whether psychopathic personality includes seemingly adaptive traits especially social physical boldness large sample adult offenders examined incremental validity operationalizations boldness fearless dominance traits psychopathy personality inventory lilienfeld andrews boldness traits triarchic model psychopathy patrick fowles krueger beyond characteristics psychopathy statistically predicting scores psychopathy related measures including psychopathy checklist revised pcl incremental validity added boldness traits predicting pcl representation psychopathy especially pronounced interpersonal traits superficial charm deceitfulness analyses however revealed unexpected sex differences relevance traits psychopathy boldness traits exhibiting reduced importance psychopathy women discuss implications findings measurement models psychopathy
optimal static output feedback osof control used obtain control force desired magnetorheological damper fitted ground first storey three storey building model modified boucwen model considered obtaining damper response exhibits non linear relationship damper force input voltage states hence obtaining input voltage realize desired control force non trivial task two voltage control laws proposed inverse quadratic voltage law iqvl inverse onoff voltage law ioovl based constraint filter implemented addition existing clipped voltage law cvl results controlled response building obtained terms peak rms values response quantities interstorey drift displacement acceleration compared existing results obtained via linear quadratic gaussian lqg control using cvl via passive control constant saturation voltage applied reduction maximum peak interstorey drift maximum rms interstorey drift performance index obtained using osof ioovl cvl control compared passive control quantities well rms storey displacements attenuated comparing osof ioovl cvl control lqg cvl control exception maximum peak interstorey drift attenuation occurs ioovl peak rms values accelerations reduced via osof compared passive lqg cvl control except considering first storey accelerations using passive control peak value applied damper force least using osof control copyright john wiley sons ltd
xxii world congress psychiatric genetics sponsored international society psychiatric genetics took place jerusalem israel october november total participants gathered discuss latest findings field following report written early career investigator travel awardees student postdoctoral attendees assigned one sessions rapporteur manuscript represents topics covered presentations conference contains major notable new findings reported copyright wolters kluwer health inc rights reserved
basis operating cooling fluid internal combustion engine cooling systems classified two macro areas air cooling system liquid cooling system four stroke engines liquid cooling system generally preferred air cooling system efficiency engine heat dissipation however thanks simplicity today engine air cooling system still widely used engine market especially two stroke engine applications like small motorbike light aircraft handheld products assure necessary heat waste air cooled engines key point optimization air flow cylinder external surface air flow separation cylinder external surface result high temperature gradients inside cylinder volume causing destructive heat problem engine avoided fine optimization cylinder fin design placed externally cylinder surface fulfil need definition specific methodology evaluate air cooling effect engine mandatory present paper authors present cfd simulation methodology designed perform detailed evaluation two stroke air cooled engines methodology applied two different engines equipping handheld brush cutter machines optimization air cooling system machine challenging task machine design must compact forcing engine parts remain quite close simulation results compared experimental evidences order verify validity proposed approach published elsevier ltd
background compared cold heat related health impacts evidence limited assessing mortality effects temperature variation accounting intra day inter day changes temperature objective used newly proposed composite indicator intra day inter day evaluated mortality associations hubei china provincial level methods daily mortality meteorological data obtained urban rural counties across hubei province china calculated using standard deviation minimum maximum temperatures exposure days quasi poisson generalized linear regression combined distributed lag non linear model first applied estimate county specific relationship mortality adjusting long term trend seasonality mean temperature relative humidity public holiday day week meta analysis conducted pool county specific estimates related mortality effects results significant positive association observed cause specific mortality except respiratory mortality ischemic heart disease mortality effect estimates varied exposure days highest days season stratified analyses showed similar results stronger mortality associations found warm season cold season elderly susceptible related mortality effects younger groups slight differences effect estimates also observed subgroups stratified gender education attainment place death urban rural areas conclusion study strengthened evidence temperature variation independent risk factor non accidental mortality preventive intervention strategies efficiently developed response global climate change minimize public health burden due unstable weather patterns elsevier rights reserved
study tested use machine learning techniques estimation ground biomass agb sonneratia caseolaris coastal area hai phong city vietnam employed gis database multi layer perceptron neural networks mlpnn build verify agb model drawing upon data survey mangrove trees sampling plots alos palsar imagery assessed model performance using root mean square error mean absolute error coefficient determination leave one cross validation also compared model usability four machine learning techniques support vector regression radial basis function neural networks gaussian process random forest mlpnn model performed well outperformed machine learning techniques mlpnn model estimated agb ranged mgha average mgha ground biomass ranged mgha average mgha total carbon stock ranged average conclude alos palsar data accurately used mlpnn models estimating mangrove forest biomass tropical areas
improvement quality value addition agricultural produces gained higher concern recent times sri lanka due creation new opportunities sale agricultural commodities open market competitive prices grading according sizes important value adding technique agricultural products also price many agricultural products varies significantly according uniformity size uniformity size makes produce attractive consumers also improve processing qualities present size grading agricultural crops including big onion carried manually crop collectors whole sellers retail sellers farmers market products without grading sri lanka persons engaging post harvest crop handling collectors whole sellers retail sellers farmers less chance use high technical costly grading technique also local market survey reported retail market price big onion bulbs significantly varied according size hence research study attempted design development low cost size grading machine size grading big onion bulbs size grading machine fabricated cast iron pvc tube designed grading onion bulbs three sizes small phi medium phicm grading machine also fabricated operate either manual electric motor machine tested grading efficiency quality accordingly machine performance optimized optimized machine adjustments maximum performance degrees inclined angle grading cylinder horizontal axis rpm rotating speed grading cylinder maximum grading qualities efficiencies optimized machine adjustments small medium large sizes reported respectively capacity grading machine hour optimized operational conditions authors published elsevier ltd
street lighting system designed features detect critical functional problems using data fusion concepts presented measurements rms voltage active power power factor intelligent algorithm capable define system anomalies failed lamps power line theft high low voltage low power factor besides typical measurements power consumption algorithm based statistical inference fuzzy logic achieve fusion measured data capability adjusting membership functions different street lighting systems different number lamps power consumption system mentioned faults simulated monte carlo method implementation two real street lighting systems algorithm implemented microcomputer raspberry python language including tele management capabilities algorithm design aspects implementation comparison simulated versus real measured values presented
spondyloarthritis refers group chronic inflammatory rheumatic diseases predominantly affects axial skeleton causing pain stiffness human bone highly dynamic organ interacts wide array cells tissues process bone remodelling relies delicate balance bone formation bone resorption orchestrated osteoblasts osteoclasts disruption homeostatic balance bone removal replacement manifest inappropriate new bone formation found spondylarthritis hypothesize vegf may promote bone remodelling stimulate angiogenesis osteoclastic osteoblastic activity anti vegf may tested dedicated therapy prevent bone remodelling spondyloarthritis patients namely cases aggressive disease bone remodelling could monitored using fluoride pet scan elsevier ltd rights reserved
aimthe aim study report analysis concept pediatric feeding problems backgroundreviews literature pediatric feeding problems disorders repeatedly reference lack shared conceptualization feeding problems difficult track aetiology prevalence incidence phenomenon available definitions diagnoses lack practical utility designan evolutionary concept analysis data sourcesa search conducted october google scholar cinahl pubmed web science databases mesh terms key words including failure thrive feeding disorder difficulty problems infantile anorexia oral aversion mealtime behaviour dysphagia inclusion criteria subject feeding problems index children years age english language full text methodsthe articles sorted disciplines authorship including psychology medicine nursing nutrition occupational therapy speech language pathology sample divided historical sample pre articles current published post current sample later reduced coded surrogate terms related concepts attributes antecedents consequences resultsthe historical view pediatric feeding problems shows tradition mother blame parental culpability direct indirect currently exist many different definitions typologies none sound validity generalizability areas attribute consensus across disciplines problematic feeding behaviours selective restrictive intake conclusiona spectrum conceptualization feeding problems suggested development attributes would critical feeding problem
graphene opened new opportunities scientific technological innovations astonishing electrical mechanical chemical thermal properties instance graphene based nanocomposites found extensive applications ion batteries libs scientists engineers seek achieve superior electrochemical performances laboratory module reported herein includes chemical fabrication electrochemical characterizations graphene nanosheets gnss gns powders fabricated chemical exfoliation graphite resulting morphological structural changes evaluated means scanning electron microscopy ray diffraction storage electrochemical characteristics gnss assessed via galvanostatic chronopotentiometry compared graphite commonly used anode material libs novel laboratory module suitable wide range students general chemistry background successfully implemented multidisciplinary laboratory lecture course entitled experimental nanomaterials nanoscience laboratory connects chemistry materials engineering real world application raises students interest awareness nanomaterials contribution renewable clean energy field
effect aki modern continuous rrt crrt methods drug disposition pharmacokinetics response poorly studied pharmaceutical manufacturers little incentive perform pharmacokinetic studies patients undergoing crrt studies neither recommended existing food drug administration fda guidance documents required new drug approval action urgently needed address knowledge deficit kidney health initiative assembled work group composed clinicians scientists representing academia fda pharmaceutical dialysis industries expertise related pharmacokinetics aki crrt work group critically evaluated key considerations assessment pharmacokinetics drug dosing crrt practical constraints related conducting pharmacokinetic studies critically ill patients generalizability observations made context specific crrt prescriptions specific patient populations order identify efficient study designs capable addressing knowledge deficit without impeding drug development considerations standardized assessment pharmacokinetics development corresponding drug dosing recommendations critically ill patients aki receiving crrt proposed
tumor necrosis factor alpha tnf inhibitors increasingly used inflammatory rheumatic diseases ird risk cardiovascular disease elevated patients ird tnf inhibitors reduce risk assessed whether beneficial effect tnf inhibitors cardiovascular risk mediated blood pressure reduction measured blood pressure levels ambulatory blood pressure measurements device patients ird months treatment tnf inhibitors study population consisted subjects men mean age years patients either rheumatoid arthritis psoriatic arthritis adalimumab common tnf inhibitor used mean systolic diastolic blood pressure levels remained treatment respectively study demonstrates tnf inhibitors effect blood pressure levels
accumulated research shown western christian religiosity often predicts prejudice toward various kinds outgroups contrary initial recent evidence indicates east asian religiosity predicts tolerance various outgroups except atheists understand differences investigated cognitive intolerance contradiction emotional disgust mechanisms possibly mediating link religiosity prejudice versus tolerance study westerners christian tradition high disgust contamination extent intolerance contradiction mediated relationship religiosity prejudice ethnic africans religious muslims moral homosexuals convictional atheists outgroups however study taiwanese buddhist taoist tradition religiosity unrelated disgust predicted low intolerance contradiction thus tolerance religious ethnic moral outgroups still atheists cultural differences cognition emotion seem explain east west differences religious prejudice
paper three dimensional finite element model power spinning aluminum alloy cylinder longitudinal hoop ribs established reveals laws stress strain distribution longitudinal hoop ribs spinning process provides theoretical guidance optimization process parameters manufacturing engineering aluminum alloy cylinder validated testes three stages first study spinning forming ten longitudinal ribs second study spinning forming ten longitudinal ribs hoop combined rib third study spinning forming qualified samples ten longitudinal ribs four hoop combined ribs optimization aspect aluminum alloy reinforced spinning parameters obtained simulation analysis experimental verification provide ideal theoretical guidance material application production
able directly study internal rule starting complicated phenomenon fractal theory describe complicated phenomenon natural world nowadays depth study exploration conducted fractal almost domains science architects paid attention contemporary architecture design gained enlightenment current parametric architecture design computer programming means introduced traditional architecture design various complicated forms surpass traditional modern buildings presented development drawn attention based latest nonlinear mathematical theory fractal geometry paper generates multiple model prototypes selection applying nonlinear ifs processes models design schemes fractal architecture paper hopes provide new design thought means architecture design
background concept well multi faceted encompassing positive negative emotions satisfaction life measuring positive negative thoughts emotions highly relevant maternity care aims optimise woman experience pregnancy childbirth focussing positive aspects health well prevention ill health yet understanding well pregnancy childbirth limited research date focussed negative aspects stress anxiety depression primary aim study describe psychometric properties newly developed well pregnancy wip questionnaire methods cohort study women attending hospital antenatal clinics belfast completed questionnaire including three general well measures pregnancy specific newly developed wip questionnaire psychometric properties questionnaire analysed using correlations explore relationship wip questionnaire generic well measures administered time exploratory factor analysis conducted results overall cronbach alpha wip principal factor analysis run wip items two factors identified one reflecting positive affect satisfaction cronbach alpha concerns cronbach alpha overall wip score wip sub scale scores displayed significant correlations well scales conclusions measuring well pregnancy important step understanding potential physical psychological social benefits pregnancy understanding well enhanced women families important life stage initial psychometric data presented wip questionnaire encouraging importantly measure provides opportunity women express positive negative emotions thoughts pregnancy thus reflecting whole spectrum well
paper development polarimetric phased array weather radar consists dual polarized antenna circular planar phase array elements discussed radar capable measuring rainfall distribution less several tens seconds digital beam forming dbf important component development process phased array radar paper precipitation radar signal simulations performed taking consideration radar concepts order discuss estimation accuracy polarimetric precipitation profiles differential reflectivity specific differential phase copolar correlation coefficient two dbf methods based fourier minimum mean square error mmse methods comparison performance two methods indicates mmse superior accuracy effect stable robust main lobe adaptively suppressed side lobes mmse also provides precipitation measurements eliminating directional dependence beam pattern improving accuracy measurements also shown estimated accuracies precipitation profiles almost independent number pulses
introduction pharmacists play key role dispensing counter emergency contraception client aims study aims evaluate knowledge counter services provided pharmacists delhi methods prestructured questionnaire based survey conducted delhi capital city india results pharmacies approached agreed participate study number packs sold month per pharmacy varied packs month sixty two percent pharmacists claimed majority clients repeated use month clients referred doctors directly approached pharmacists nearly one third clients adolescents sixty seven percent pharmacists adequate knowledge asked last menstrual period time elapsed since last unprotected intercourse pharmacist inquired whether one multiple unprotected acts intercourse regular contraceptive method used explored reason intake explained dosage schedule clients half explained client may experience side effects none pharmacists advised clients sexually transmitted disease screening counseled clients regarding regular contraception conclusion improving quality services provided pharmacists clear misconceptions clients promote subsequent regular contraception along precautions avoid sexually transmitted diseases
biofuels transitioned technology expected deliver numerous benefits highly contested socio technical solution initial hopes potential mitigate climate change deliver energy security benefits rural development particularly global south unravelled face numerous controversies recognition negative externalities associated biofuels european union developed sustainability criteria enforced certification schemes paper draws literature stewardship analyse outcomes schemes two countries guatemala explores two key issues first european union biofuels policy shaped biofuel industries guatemala second implications sustainable land stewardship drawing attention outcomes european demand biofuels raise questions ability european policy drive sustainable land practices two cases paper concludes rather promoting stewardship current governance framework effectively rubberstamps existing agricultural systems serves embed existing inequalities
background psychosocial distress contribute avoidance refusal discontinuation cancer treatment could impact recovery survival aims aim present study evaluate effectiveness community based psychosocial program alleviating mood disturbance breast cancer survivors different stages breast cancer journey method total women participated week psychosocial program local community centre weekly hour program delivered small group format program components included health education behavioural training cognitive behavioural therapy art therapy stress management questionnaires aimed assessing psychiatric morbidity mood adjustment administered beginning program pre completion program post results group data revealed significant reduction psychiatric morbidity improved psychological adjustment participants divided degree psychiatric morbidity mild moderate severe severe significant reduction reporting anxiety symptoms mild moderate severe severe groups reported depression symptoms severe severe groups noted anger confusion somatic symptoms mild group noted level activity also significantly improved severe group conclusions structured community based psychosocial program beneficial women struggling come terms emotional consequences breast cancer stages recovery
autoimmune polyendocrinopathy candidiasis ectodermal dystrophy apeced rare disorder immune dysregulation caused mutations autoimmune regulator aire gene individuals affected apeced develop clinical syndrome characterized ectodermal abnormalities autoantibody production organ specific autoimmune manifestations inflammatory arthritis usually described part syndrome sporadic cases reported describe case preschool age girl presented hypoparathyroidism hepatitis interstitial pneumonitis chronic polyarthritis years age found two compound heterozygous disease associated mutations aire gene also conducted literature review main characteristics inflammatory arthritis apeced patients case review demonstrate inflammatory arthritis although rare early manifestation apeced diagnosis apeced considered mucocutaneous candidiasis multiple organ specific autoimmune manifestations polyendocrinopathy especially hypoparathyroidism adrenal failure ectodermal dystrophy accompany joint symptoms genotyping interpretation take account mutations found exons gene compound heterozygosity common cases one mutated alleles found
many object instance retrieval systems typically based matching local features sift however local descriptors serve low level clues sufficiently distinctive prevent false matches recently deep convolutional neural networks cnn shown promise semantic aware representation many computer vision tasks paper propose novel approach employ cnn evidences improve sift matching accuracy plays critical role improving object retrieval performance weaken interference noise extract compact cnn representations number generic object regions query adaptive method proposed choose appropriate cnn evidence verify pre matched sift pair two different visual matching verification functions introduced evaluated moreover investigate suitability fine tuning cnn proposed approach extensive experiments benchmark datasets demonstrate effectiveness method particular object retrieval results compare favorably state art methods acceptable memory usage query time elsevier rights reserved
present article report europium doped strontium ortho silicates namely srsio xeu mol phosphors prepared solid state reaction method crystal structures sintered phosphors consistent orthorhombic crystallography pmna space group chemical compositions sintered phosphors confirmed energy dispersive ray spectroscopy eds thermoluminescence kinetic parameters activation energy order kinetics frequency factors calculated peak shape method orange red emission originating transitions ions could clearly observed samples excited combination emissions constituted orange red light indicated commission internationale eclairage cie chromaticity diagram mechanoluminescence intensity prepared phosphor increased linearly increasing impact velocity moving piston suggests phosphors also used sensors detect stress object thus present investigation indicates piezo electricity responsible producing prepared phosphor
new process based thermal hydraulic conversion actuated low grade thermal energy investigated input thermal energy provided means solar collectors well low temperature energy sources following article thermo hydraulic term refers process involving incompressible fluid used intermediate medium transfer work hydraulically different thermal operated components sub systems system aims providing trigeneration energy features residential sector providing heating cooling electrical power meeting energy needs domestic houses innovative system made two dithermal processes working two different levels temperatures featuring two different working fluids first process able directly supply either electrical energy generated hydraulic turbine drives second process thanks incompressible fluid similar heat pump effect heating cooling purposes innovative aspect process relies use hydraulic transfer fluid transfer work sub system therefore simplifying conversion chain model assuming steady state operation developed assess energy performances different variants thermo hydraulic process various heat source temperatures degrees heat sinks degrees well various pairs working fluids instance frame single family home located mediterranean region working fluid pairs ryf rzd investigated detail order estimate annual performances domestic houses process aims amplifying solar energy collected factor heating purpose provides cold production coefficient performance generates electricity remaining solar energy efficiency reducing electrical auxiliary consumption overall greenhouse gas emissions elsevier ltd rights reserved
number casualties economic losses alarming caused geological disasters year china serious prevent control geological disaster order make graduate students master theory practical skills geological disaster prevention control work paper focuses construction significance geological hazard case database summarize work practical problems put forward construction geological disaster case base ideas construction case base adopts structure total minute strictly follows principle comprehensiveness extensiveness typicality gradient present domestic geological disaster control engineering design related colleges universities geological hazard risk assessment courseware collected necessary course geological disaster prevention control use case teaching method bring innovation teaching curriculum training geological disaster prevention treatment talents promote work geological disaster prevention control new level
alpha synuclein primary protein found lewy bodies protein lipid aggregates associated parkinson disease lewy body dementia protein folds uniquely long amphipathic alpha helix bound membrane high enough concentrations induces large scale remodeling membranes tubulation vesiculation engineering less hydrophobic variant alpha synuclein previously showed energy associated binding alpha synuclein correlates extent membrane remodeling braun chem soc study combine fluorescence correlation spectroscopy electron microscopy vesicle clearance assays coarse grained molecular dynamics simulations test impact decreasing length amphipathic helix membrane binding energy tubulation show truncation alpha synuclein length approximately reduces membrane binding affinity fivefold membrane remodeling capacity nearly per mole bound protein basis results simulations correlate well experiments lend support idea high protein density stabilization individual protein induced membrane curvature fields extent curvature fields stabilized function binding energy dictates extent tubulation somewhat surprisingly find stabilization correlate directly geometric distribution proteins membrane surface
constructing smooth surface representations point clouds fundamental problem geometric modeling computer graphics wealthy literature focused problem among many approaches implicit surface reconstruction central topic past two decades due ability represent objects complicated geometry topology recently problem reducing storage requirement implicit representations attracted much attention paper propose phase field guided implicit surface reconstruction method tackle problem implicit function method behaves like phase field binary system takes distinct values phases smooth transition given unorganized point cloud present method construct phase filed function represented hierarchical spline whose zero level set approximates point cloud much possible unlike previous approaches mathematical model avoids use normal information point cloud furthermore demonstrated experimental results method achieve compact representation since mainly need save coefficients hierarchical spline function within narrow band near point cloud ability method produce reconstruction results high quality also validated experiments published elsevier
integrated hydrological geophysical groundwater modeling studies carried identification suitable sites rainwater harvesting structures groundwater augmentation rrcat campus indore based studies ten check dams two contour bunds one earthen bund recommended existing stream channels valley fills respectively likely water impoundment structures calculated keeping view length width stream channels based study groundwater flow model using modflow carried keeping view geologic hydrologic conditions area net rechargeable impounded rain water structures groundwater regime calculated monsoon seasons varied net enhancement groundwater recharge structures would around mcm year water level existing well would rise present level future groundwater augmentation
backgroundsalted sun dried meat traditional process meat salting improve quality overall acceptance present study compared physicochemical sensory attributes fresh salted sun dried meat nellore zebu bos taurus indicus bulls evaluated diets containing different levels licury cake diets provided nellore finished feedlot resultssalted sun dried meat decreased moisture ether extract contents increased ash protein contents compared fresh meat addition licury resulted linear increases moisture quadratic effects warner bratzler shear force fresh meat cooking weight loss warner bratzler shear force reduced manufacturing process sun dried meat sun dried meat presented greater color index values lower index color conclusionlicury cake used dry matter diets finish animals feedlot without lessening quality fresh meat sundried meat salted sun dried meat presented greater overall acceptance society chemical industry
peroxisome proliferator activated receptor alpha ppar alpha ligand activated transcription factor abundantly expressed liver ppara activated fatty acids various lipid species well class chemicals referred peroxisome proliferators studies mice shown ppara serves master regulator hepatic lipid metabolism fasting addition ppara suppresses inflammation acute phase response comparatively little known ppara human liver overview provided role regulation ppara human liver main outcomes level ppara mrna expression human mouse liver similar expression ppara human liver reduced patients non alcoholic steatohepatitis infected hepatitis virus ppara human liver able effectively induce expression numerous genes involved numerous lipid metabolic pathways including microsomal peroxisomal mitochondrial fatty acid oxidation fatty acid binding activation fatty acid elongation desaturation synthesis breakdown triglycerides lipid droplets lipoprotein metabolism gluconeogenesis bile acid metabolism various metabolic pathways genes ppara activation human liver causes regulation large number genes involved various immunity related pathways peroxisome proliferators promote tumour formation human liver opposed mouse liver structural functional differences human mouse ppara addition helping correct dyslipidemia ppara agonists may hold promise therapy patients cholestatic liver diseases non alcoholic fatty liver disease type diabetes elsevier societe francaise biochimie biologie moleculaire sfbbm rights reserved
despite implementation multiple sophisticated safety barriers well blowout undesired disaster petroleum industry still happens macondo montara incidents show crush crude price pushed operators toward cost cutting plans plans short terms may significantly reduce exploration operation costs relieve financial pressures hand measures may also compromise balance among safety reliability cost long term potentially lead catastrophic accidents current regulation gulf mexico region requires operators report single value worst case discharge wcd possible blowout however provide additional value manage risk uncontrolled wellbore flow event impact marine environment paper practical comprehensive oil spill risk assessment method introduced couples reservoir wellbore models distribution uncertainties depict risk picture uncontrolled wellbore flow events statistical design experiments conducted determine important uncertainties blowout risk shown sensitivity analysis method guide operators allocate limited resources important barriers make proper risk reduction plans blowout risks effectively controlled institution chemical engineers published elsevier rights reserved
paper discuss well posedness asymptotic behavior doubly nonlinear problem describing vibrations kelvin voigt string beam system models suspension bridge model obtain existence uniqueness solutions exponential stability homogeneous system provided constant axial force smaller critical value general existence regular global attractor proved external loads independent time
background disease flares established atopic dermatitis generally associated low diversity skin microbiota staphylococcus aureus dominance temporal transition skin microbiome early infancy dysbiosis established unknown methods randomly selected children cork babies scope evaluating longitudinal impact using neurological andnutritional endpoints baseline longitudinal birth cohort microbiome sampling points first months life skin sites relevant antecubital popliteal fossae nasal tip cheek identified infants compared randomly selected control infants performed bacterial ribosomal rna sequencing analysis directly clinical samples results bacterial community structures diversity shifted time suggesting age strongly affects skin microbiome infants unlike established patients infantile noticeably dysbiotic communities disease colonized aureus comparing patients control subjects infants affected skin month statistically significant differences bacterial communities antecubital fossa month compared infants unaffected month particular commensal staphylococci significantly less abundant infants affected month suggesting genus might protect later development conclusions study suggests month old infants colonized aureus additional studies needed confirm whether colonization commensal staphylococci modulates skin immunity attenuates development
purpose study examine whether social relationships associated sleep status chinese undergraduate students cross sectional questionnaire survey conducted november huzhou teachers college china questionnaire involved demographic characteristics personal lifestyle habits social relationships pittsburgh sleep quality index psqi associations social relationships sleep status analyzed using regression models adjustment potential factors poor sleep quality prevalent among chinese undergraduate students men tended better sleep women lower social stress better management stress good social support correlated better sleep status stress support friends family classmates related sleep variables weak associations number friends sleep detected results consistent men women educators instructors aware importance social relationships well healthy sleep undergraduates elsevier ireland ltd rights reserved
radix sophorae tonkinensis tonkinensis used chinese folk medicine treat sore throats viral hepatitis jaundice however little known hepatotoxicity induced study investigate hepatotoxicity induced radix tonkinensis potential supplemental biomarker liver injury acute toxicity accumulative toxicity tolerance test sub chronic toxicity contents cytisine cyt matrine oxymatrine omt radix tonkinensis extracts determined simultaneously method developed acute toxicity study mice scheduled single oral gavage doses radix tonkinensis extracts respectively another three groups mice received radix tonkinensis extracts orally single doses two groups hepatic injury model induced intraperitoneal injection carbon tetrachloride cci mortality rate analysis serum biochemistry histopathological examination used assess acute toxicity accumulative toxicity study mice treated radix tonkinensis extracts orally method dose escalation days respectively accumulative toxicity assessed mortality rate tolerance test half mice test group accumulative toxicity administered dose radix tonkinensis extracts rest mice test group assigned receive dose radix tonkinensis extracts sub chronic toxicity study mice treated daily doses radix tonkinensis extracts days assessments body weights serum biochemical analysis histopathological examination performed enzyme inhibition assay butyrylcholinesterase buche acetylcholinesterase ache cyt omt also carried contents cyt omt radix tonkinensis extracts respectively acute toxicity study radix tonkinensis extracts mice found dead accumulative toxicity study acute toxicity tolerance test increased alt ast che levels observed dose response manner severity histological changes liver shown dose dependent mode sub chronic toxicity though decline trend altand ast levels found radix tonkinensis extracts compared control might related weight loss severity histopathological changes liver increased serum che level shown dose response manner omt cyt showed inhibitory effects buche ache enzyme inhibition assay results study indicate radix tonkinensis hepatotoxicity increased serum che potential supplemental biomarker liver injury elsevier gmbh rights reserved
paper presents design active building block analog signal processing named current controlled differential difference current conveyor ccddcc parasitic resistances terminal controlled input bias current proposed element realized cmos technology displays usability new active element maximum bandwidth voltage current followers around ghz mhz respectively thd obtained around within vpp input range power dissipation ccddcc biased current obtained around power supplies addition current mode multiple input single output miso second order universal analog filter included applications filter offers realization simultaneous five type standard filter responses quality factor frequency response parameters independently tuned spice simulation results proposed ccddcc applications also presented
perceptual adaptation image pai introduced inspiration chevreul mach bands cmb visual phenomenon boosting cmb assisting illusory effect boundaries regions pai adapts image perception human visual system thereof increases quality image pai proposed application standard images output image processing technique implementation pai image algorithm morphological filters mfs presented geometrically adds model cmb effect numerical evaluation improvement ratios four reference image quality assessment iqa indexes approves pai performance noticeably observed visual comparisons furthermore pai applied postprocessing block classical morphological filtering weighted morphological filtering median morphological filtering cancelation salt pepper gaussian speckle noise mri images specified iqa indexes validate pai effect image enhancement benchmarked upon morphological image sharpening high boost filtering
energy resource efficient manufacture consumption investment products becoming competitive advantage companies increasingly interested optimal machine design process operation contribution analytical description milling process derived basis extensive experimental power resources consumption analysis using discrete events modeling approach parameterized process model milling developed calculation resources consumption machine components process operations controlled codes allows time depended consumption profiles consumption optimization resources energy tool wear coolant material removal volume operation time considered either single combined resources minimization authors published elsevier
study distributed approach account dynamic friction needle insertion soft tissue presented well known friction complex nonlinear phenomenon appears classical static models unable capture observations made systems subjected significant frictional effects needle insertion translational friction would matter importance needle flexible stop rotate motion profile low insertion velocities implemented thus system repeatedly transitioned pre sliding sliding mode vice versa order characterize friction components distributed version lugre model state space representation adopted method also facilitates estimating cutting force intra operative manner evaluate performance proposed family friction models experiments conducted homogeneous artificial phantoms animal tissue results illustrate approach enables represent main features friction major force component needle tissue interaction needle based interventions
background genital anal oral injuries sustained sexual intercourse may explain hiv transmission among women determined variability genitoanal injury frequency prevalence women consensual sexual intercourse exploring role menstrual phase hormonal birth control methods used longitudinal observational design convenience sample women aged years older participants baseline interview gynecological examination followed consensual sexual intercourse male partner second gynecological examination analyzed injury prevalence logistic regression injury frequency negative binomial regression among women menstrual using hormonal birth control menstrual using hormonal birth control menopausal also compared injury among menstrual women follicular ovulatory luteal phases findings women using hormonal birth control external genitalia injuries adjusted rate ratio arr twice anal injuries arr nonhormonal birth control menstruating group menopausal women times anal injuries arr nonhormonal menstrual group among menstrual women follicular phase greater prevalence frequency external genitalia injuries phases interpretation increased rates postcoital genitoanal injuries noted among women using hormonal birth control follicular phase menstruation biological factors influence women risk hiv warrant investigation
green roofs grs becoming trend urban areas favouring thermal performance buildings promoting removal atmospheric pollutants acting possible water collection spots rainwater harvesting systems buildings also contribute management stormwater runoff reducing flood peaks technologies enhanced mediterranean countries water scarcity increasing occurrence extreme events becoming significant result climate change extensive pilot three aromatic plant species satureja montana thymus caespititius thymus pseudolanuginosus designed study several parameters affecting rainwater runoff operation months physico chemical analyses roof water runoff turbidity conductivity chemical oxygen demand shown water sufficient quality non potable uses buildings toilet flushing innovative approach allowed development expression predict monthly runoff coefficient system parameter essential planning designing grs combined rainwater harvesting systems mediterranean climate study contribution improving basis design rainwater harvesting systems buildings extensive grs mediterranean climate
previous work suggests estradiol regulates expression hippocampal parvalbumin well hippocampus dependent spatial memory mice parvalbumin interneurons generate neuronal oscillatory activity gamma frequency range gamma oscillations closely linked higher cognitive functions raloxifene selective estrogen receptor modulator shows beneficial effects human cognitive performance peripheral side effects unlike estradiol biological mechanisms underpin benefits clear study aimed investigate whether estradiol raloxifene modulate hippocampal gamma band oscillations spatial memory performance prepubescent female mice ovariectomized ovx implanted subcutaneous pellet either estradiol raloxifene placebo adulthood local field potentials recorded dorsal hippocampus mice performing maze hippocampus dependent spatial memory task ovariectomy caused deficits spatial memory accompanied significant reduction hippocampal gamma oscillations specifically decision making estradiol well raloxifene rescued behavioural electrophysiological deficits data significant implications disorders cognitive impairment altered gamma oscillations apparent schizophrenia elsevier ltd rights reserved
exploring resting state brain functional connectivity autism spectrum disorders asd using functional magnetic resonance imaging fmri data become popular topic past years data standard brain template consist voxel specific points time human subject ultra high dimensionality makes voxel level functional connectivity analysis involving four billion voxel pairs statistically computationally inefficient work introduce new framework identify functional brain network anatomical region level individual propose two pairwise tests detect region dependence one multiple testing procedure identify global structures network limiting null distribution test statistic derived also shown tests rate optimal alternative block networks sparse numerical studies show proposed tests valid powerful apply method resting state fmri study autism identify patient unique control unique hub regions findings biologically meaningful consistent existing literature elsevier inc rights reserved
concept sustainability regarded threefold environmental economic social usually identified triple bottom line sustainability often represented three intertwined circles therefore construction sustainable environmentally economically socially sustainable however extent green building rating tools evaluate three pillars sustainability questionable research aims analyze effectiveness eight international green building rating tools evaluating environmental economic social sustainability buildings credit points rating tool initially categorized based related category sustainability comparison analysis carried based normalized score finally comparison result presented radar diagram three case study buildings also analyzed based credit points achieved accordingly environmental sustainability widely considered green building rating tools economic sustainability rarely evaluated social sustainability evaluated green building rating tools would approximately amount credit points allocated rating tool american society civil engineers
background aims major changes emerged last years therapy chronic hcv several direct acting antiviral agents developed showing potent activity higher rates sustained virological response even difficult treat patients study explores real life experience concerning efficacy safety possible predictors response first cohort egyptian patients chronic hcv genotype treated sofosbuvir simprevir combination therapy methods real life study recruited first chronic hcv genotype egyptian patients received antiviral therapy viral hepatitis specialized treatment centres affiliated national committee control viral hepatitis enrolled patients received weeks course daily combination sofosbuvir simeprevir patients closely monitored treatment safety efficacy results overall sustained virological response rate end treatment response rate sustained virological response rates easy difficult treat groups respectively univariate multivariate logistic regression analysis revealed significant association low albumin treatment failure fatal adverse events occurred cases due liver cell failure adverse events saes leading treatment discontinuation occurred patients conclusion sofosbuvir simeprevir combination effective well tolerated regimen patients chronic hcv genotype
background although human lymphotropic virus type htlv infection prerequisite development htlv associated myelopathy tropical spastic paraparesis ham tsp specific provirus mutations ham tsp yet reported study examined whether ham tsp patients disease specific genomic variants htlv analyzing entire sequences htlv proviruses patients including familial cases addition investigated genetic variants host restriction factors conferring antiretroviral activity determine mutations may related resistance susceptibility ham tsp results subjects included patients familial ham tsp ham tsp patients sporadic ham tsp ham tsp asymptomatic htlv carriers acs samples samples classified transcontinental subtype samples classified japanese subtype among three groups percentage transcontinental subtype ham tsp ham tsp acs respectively frequency transcontinental subtype significantly higher ham tsp ham tsp acs fifty mutations htlv sequences significantly frequent ham tsp patients acs however common transcontinental subtype among mutations ten common mutations causing amino acid changes htlv sequences specific transcontinental subtype examined host restriction factors detected rare variant trim alpha ham tsp patients patients trim alpha showed lower proviral loads pvls copies pbmc patients variant trim alpha significantly higher pvls copies pbmc could find ham tsp specific mutations host restriction factors conclusions transcontinental subtype susceptible ham tsp especially familial cases ten common mutations causing amino acid changes htlv gene specific transcontinental subtype trim alpha polymorphisms associated pvls indicating trim alpha could implicated htlv replication
introduction individuals criminal justice system represent current smokers smoking banned jails prisons cessation focus population shifted individuals community correction supervision probation parole aim study examine predictors successful smoking cessation among criminal justice individuals supervised community methods five hundred participants community corrections supervision randomized receive either four sessions smoking cessation counseling counseling conjunction weeks bupropion treatment plus brief physician advice quit logistic regression analyses examined associations smoking variables medication adherence successful abstinence mediation analysis evaluated indirect effects medication adherence smoking abstinence results strongest associate medication adherence previous use bupropion strongest associate smoking abstinence medication adherence mediation analysis indicated previous use bupropion indirectly increased cessation rates pathway increased medication adherence conclusions results highlight importance medication adherence smoking cessation among community corrections smokers providing exposure medication may promising intervention increase medication adherence subsequent cessation rates population elsevier ltd rights reserved
study aims examine associations comorbid conditions healthcare utilization medical charges mortality patients rheumatoid arthritis nebraska state emergency department discharge hospital discharge death certificate data used study comorbid conditions patients defined using standard international classification diseases icd icd comorbid conditions patients patients without comorbid conditions majorly related healthcare utilization mortality patients addition injury fracture sprains strains symptoms cardiovascular digestive systems respiratory infection chronic obstructive pulmonary disease copd common comorbid conditions visits addition joint replacement fracture infections copd cardiovascular comorbidities common comorbid conditions hospitalizations cardiovascular cerebrovascular respiratory comorbidities dementia malignant neoplasm diabetes mellitus common comorbid conditions deaths patients addition numbers comorbid conditions significantly associated length hospital stay hospital charges patients findings study indicated comorbid conditions associated healthcare utilization medical charges mortality patients
purpose overactive bladder oab causes urinary urgency usually accompanied frequency nocturia alpha adrenergic receptor alpha antagonists known improve lower urinary tract symptoms associated oab antagonists constitute variety drugs according receptor subtype affinity study investigated efficacy tamsulosin naftopidil combination two oab rats methods oab rat model induced intraperitoneal injection cyclophosphamide days experimental groups divided groups control group oab induction group oab induction tamsulosin monotherapy group oab induction naftopidil monotherapy group oab induction tamsulosin naftopidil combination therapy group drug treated groups drug administrated days oab induction cystometry uro dynamic evaluation immunohistochemical stain fos nerve growth factor ngf expressions central micturition centers performed results increased contraction pressure time enhanced fos ngf expressions central micturition centers found oab rats tamsulosin suppressed contraction pressure time inhibiting fos ngf expressions naftopidil showed significant effect combination therapy showed less effect contraction pressure time naftopidil combination therapy exerted significant effect fos ngf expressions conclusions tamsulosin showed prominent efficacy treatment oab compared naftopidil combination combination tamsulosin naftopidil showed synergistic effects oab however studies add therapy might provide opportunities find new modality
blind digital image watermarking scheme based spatial domain presented investigated paper watermark embedded intermediate significant bit planes besides least significant bit plane address locations determined pseudorandom address vector pav watermark embedding using pav makes difficult adversary locate watermark hence adds security system scheme evaluated ascertain spatial locations robust various image processing geometric attacks jpeg compression additive white gaussian noise salt pepper noise filtering rotation experimental results obtained reveal interesting fact mentioned attacks rotation higher bit plane watermark embedded robust system perceptual quality watermarked images obtained proposed system compared state art watermarking techniques proposed technique outperforms techniques comparison even compared worst case peak signal noise ratio obtained scheme
previous research demonstrated way adults interact children autism great impact spontaneous communication however date studies focused modifying adults behaviour even fewer conducted school settings actively involve teaching staff designing intervention aims study twofold explore extent staff able build good practice alter interactive style assess effects change children communication study used action research methodology involved three members staff six children autism staff researcher developed adult interactive style intervention aisi partnership based two theoretical models child development disability data collected pre post intervention follow months end main study measure change results showed staff considerably increased number times used aisi principles post intervention change significant impact children spontaneous communication three staff took active participatory role study considered positive empowering experience
overcome limitations traditional long span suspension bridges steel cables mechanical behavior suspension bridges various fiber reinforced polymer frp hybrid frp cables investigated comprehensively authors adopted prototype proposed messina strait bridge main span use suspension bridge model analysis static dynamic behaviors entire suspension bridge steel different frp cables analyzed using finite element method results indicate application frp cables long span suspension bridge benefits spanning ability improves load carrying efficiency reduces axial force cable modal analysis results show long span suspension bridge cables different materials similar mode shapes although natural frequencies bridges frp cables larger bridge steel cable lower self weight also revealed adoption frp cables decreases seismic responses suspension bridge better energy dissipation behavior frp cables improve flutter critical wind speed contribute overall aerodynamic stability large span suspension bridges
background systemic inflammation emerged promising marker potential mechanism underlying post traumatic stress disorder ptsd relationship posttraumatic stress pathology systemic inflammation however consistently replicated potentially confounded comorbid illness injury common complications trauma exposure methods analyzed large naturalistic cohort sharing discrete physical mental health trauma destruction world trade center wtc towers september evaluated relationship multiple physical mental health related indices collected routine evaluations wtc environmental health center wtc ehc treatment program community members exposed disaster reactive protein crp marker systemic inflammation examined relation scores ptsd ptsd symptom clusters experiencing avoidance negative cognitions mood arousal depression anxiety controlling wtc exposures lower respiratory symptoms age sex bmi smoking potential risks confounders results crp positively associated ptsd severity trending toward association depression anxiety crp positively associated experiencing avoidance symptom clusters trended toward associations negative cognitions mood arousal conclusions large study relationship crp posttraumatic stress pathology demonstrated association systemic inflammation stress pathology ptsd trending depression remained adjusting potentially confounding variables results contribute research findings suggesting salient relationship inflammation post traumatic stress pathology authors published elsevier ltd
strength materials high strain levels determined using called continuous bending tension cbt test modified tensile test specimen subjected repetitive bending time test enables create high levels uniform strain wide variety materials tested way strength material cbt testing measured different ways secondary tensile tests interrupted cbt tests directly fracture cbt test methods yield similar results strength largely unaffected cyclic pre deformation mainly depends overall increase length multi phase materials strength shows minor influence cbt test conditions hardening follows extrapolated hardening observed conventional tensile test except brass test method potentially used measuring hardening curves high strain levels
cutting movements football soccer induce high loads anterior cruciate ligament knee injury risk affected shoe surface interaction evaluation different influencing factors interaction traktester custom made device used obtain significant results testing acl loading realistic plantar pressure distribution shoe required using traktester several cutting movements carried using two different foot models resultant plantar pressure analysed three different systems original foot model parotec insoles integrated sensors paromed gmbh markt neubeuern germany modified version foot model pedar insoles sensors novel gmbh munich germany inflexible model surveyed opengo science system sensors moticon munich germany inflexible model distinct angles lower leg surface adjusted obtained plantar pressure distributions analyzed first version showed high pressures arch region modified reduce load area second inflexible model induced pressure heel forefoot region various angles similar plantar pressure distributions obtained highest pressures applied medial side heel forefoot minor load arch region corresponds literature data investigating cutting movements subjects tests inflexible foot model achieved similar realistic patterns plantar pressure distribution different angles important precondition obtain reproducible data acl loading cutting movements authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
objective prior studies aggressive end life care older patients cancer accounted social determinants health race income education rarely multimoribidity study examine association end life care social determinants health hypothesizing higher associated less aggressive care methods linked health retirement study medicare data national death index identified fee service patients age years died cancer defined occurrence occurrence chronic conditions functional limitations geriatric syndromes aggressive care based claims derived measures receipt cancer directed treatment last two weeks life admission hospital emergency department within last month hospital death also identified patients enrolled hospice multivariable logistic regression models analyzed associations interest adjusting potential confounders results patients enrolled hospice underwent cancer directed treatment admitted hospital died hospital observed shaped distribution income hospital death chronic conditions geriatric syndromes associated outcomes others conclusions improve quality end life care curtail costs incurred dying patients relevant interventions need account social determinants health nuanced fashion elsevier ltd rights reserved
objective assess three dimensional vision syndrome among viewers three dimensional movies methods cross sectional study conducted ziauddin university karachi july november among viewers three dimensional movies frequency three dimensional vision syndrome end movie assessed self administered questionnaire used collect data immediately end movie data analysed using spss results participants overall mean age years participants male female common symptoms tired eyes blurred vision headache found movie among individuals whereas end movie among viewers respectively movies duration hours also likely associated three dimensional vision syndrome end movie conclusion watching three dimensional movies increased likelihood visual fatigue visually induced motion sickness
first component sparc simulation package initio real space calculations present accurate efficient finite difference formulation parallel implementation density functional theory dft isolated clusters specifically utilizing local reformulation electrostatics chebyshev polynomial filtered self consistent field iteration reformulation non local component force develop framework using finite difference representation enables efficient evaluation energies atomic forces within desired accuracies dft selected examples consisting variety elements demonstrate sparc obtains exponential convergence energy forces domain size systematic convergence energy forces mesh size reference plane wave result comparably high rates forces consistent energy free noticeable egg box effect accurate ground state properties including equilibrium geometries vibrational spectra addition systems consisting thousands electrons sparc displays weak strong parallel scaling behavior similar well established optimized plane wave implementations significantly reduced prefactor overall sparc represents attractive alternative plane wave codes practical dft simulations isolated clusters program summary program title sparc catalogue identifier afbl program summary url http cpc qub summaries afbl html program obtainable cpc program library queen university belfast ireland licensing provisions gnu gpl lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language cic computer system compiler operating system linux ram problem dependent ranges system electrons classification external routines petsc http www mcs anl gov petsc mkl https software intel com intel mkl mvapich http mvapich cse ohio state edu nature problem calculation electronic structural ground states isolated clusters framework kohn sham density functional theory dft solution method high order finite difference discretization local reformulation electrostatics terms electrostatic potential pseudocharge densities calculation electronic ground state using chebyshev polynomial filtered self consistent field scf iteration conjunction anderson extrapolation mixing evaluation boundary conditions electrostatic potential truncated multipole expansion reformulation non local component force geometry optimization using polak ribiere variant non linear conjugate gradients secant line search restrictions system size less similar electrons local density approximation lda troullier martins pseudopotentials without relativistic non linear core corrections running time problem dependent timing results selected examples provided paper elsevier rights reserved
strand tension control essential suspension bridge safety however quantitative studies examined bending rigidity boundary condition behavior strands anchor span suspension bridges special structure complex configuration paper new calculation method strand tension explored using dynamic balance theory determine effect bending rigidity boundary conditions accuracy effectiveness proposed method tested confirmed verification examples application nanxi yangtze suspension bridge china results indicated low order frequency calculation could used calculate strand tension without considering effect bending rigidity ensure control accuracy influence bending rigidity control precision related tension length strands significantly determined specific value stress rigidity bending rigidity uncertain boundary conditions anchor span cable fixed consolidated hinged also major effect control accuracy improve accuracy strand tension control least squares method proposed tension construction control anchor span approach significantly improve accuracy tension control main cable strand recommendations future bridge analysis provided based results study
background tobacco smoke exposure tse unequivocally harmful children health yet children visit pediatric emergency department ped urgent care setting exposed tobacco smoke incorporation clinical decision support systems cdss electronic health records ehr ped patients may improve rates screening brief tse intervention caregivers result decreased tse children objective propose study first develop evaluate integration cdss registered nurses rns ehr pediatric patients facilitate identification caregivers smoke delivery tse interventions caregivers urgent care setting methods conduct two phase project develop refine integrate evidence based cdss pediatric urgent care setting rns provide input program content function design phase develop cdss prompts ask child tse caregiver smoking use software program research electronic data capture redcap advise caregivers reduce child tse via total smoking home car bans quitting smoking assess interest quitting assist caregivers quit directly connecting choice free cessation resources quitline smokefreetxt smokefreegov urgent care visit create reports provide feedback rns tse counseling behaviors phase conduct month feasibility trial test results implementing cdss changes rns tse related behaviors child caregiver outcomes results trial currently underway funding support national institutes health national cancer institute completed phase cdss developed input advisory panel rns pilot tested nearing completion phase conducting feasibility trial analyzing data disseminating results conclusions project develop iteratively refine integrate pilot test use innovative cdss prompt rns provide tse reduction smoking cessation counseling caregivers smoke successful approach create sustainable disseminable model prompting pediatric practitioners apply tobacco related guideline recommendations systems based approach potential reach least million smokers year significantly reduce tse related pediatric illnesses related costs
framing paper introduces symposium gender radical right exception recent studies gender issues received little attention research european radical right purpose symposium address examine whether radical right parties still men parties parties led supported primarily men extent women women concerns included parties argues radical right parties changed appeal since origins evidence fact radical right parties least countries exhibit active political involvement women engage representation women concerns puts standardised political position vis vis parties given current lack focus topic given recent gendered changes radical right parties symposium stresses academic political importance studying gender relations radical right politics
paper proposed technique optimize power generated small scale wind turbine wind speed measurement uncertain knowledge power coefficient curve characteristic first kalman like observer used estimating power coefficient characteristic used nonlinear control strategy electrical generator secures power maximization uncertain power coefficient function adjusted recursive least square algorithm uses estimate power coefficient reliable information finally adjusted power coefficient polynomial computed optimal electrical generator speed reference leads system operate near theoretical optimal power methodology illustrated simulated example compared case wind speed measured
background previous research suggests bipolar disorder characterized deficits cognitive control impaired found high risk samples associated maintenance symptoms remains unclear however whether characterized general deficit deficit specifically related processing emotional material methods sample consisted remitted bipolar patients healthy controls examined whether individuals display impaired confronted negative well positive material using arithmetic inhibition task required inhibition pictorial stimulus material results whereas groups showed difficulties exerting negative material individuals exhibited deficient positive material limitations even though intended negative positive pictures arithmetic inhibition task similarly arousing participants current study rated negative compared positive pictures arousing conclusions associated impaired processing emotional especially positive stimuli even patients remission possible implications deficit especially emotion regulation discussed
relational databases created purpose handling organizing sensitive data organizations well individuals although database security mechanisms network intrusion detection systems idss present found inadequate unsuitable detecting threats specifically directed toward database application layer therefore ids especially database needed paper propose random forest weighted voting wrf principal components analysis pca feature selection technique task detecting database access anomalies assuming database role based access control rbac model place pca produces uncorrelated relevant features time reduces dimensionality easier integration large databases exploits inherent tree structure syntax sql queries weighted voting scheme minimizes false alarms experiments showed wrf result improved false positive false negative rates also fast terms model building anomaly detection time moreover given query classification accuracy found significantly affected type command tables accessed turn explains confusion role classes lastly pca outperforms state art data mining techniques task database anoinaly detection wrf achieved best performance even skewed data elsevier inc rights reserved
study examined differences frequency type injury children autism pervasive developmental disorder pdd compared typically developing peers groups insured medicaid relative rate emergency hospital treatment injury children autism pdd compared controls confidence interval controlling age gender children autism pdd higher rate head face neck injuries lower rate sprains strains treatment poisoning times frequent self inflicted injury also times frequent children autism pdd
globalized context reconciling private family professional life assumes preponderant part feminization migration analyses however knowledge existing dynamics among immigrant families still scarce portuguese academic literature specially immigrant women organize family lives action modalities terms reconciliation marques gois sense main objective research characterize analyze immigrant women experiences speeches private family professional life reconciliation research based qualitative approach inserted critical paradigm offered social feminism constructionism empirical basis built ten brazilian immigrant women living braga district using thematic analysis methodology results show regular asymmetric pattern domestic chores child care places immigrant women receiving country bigger overload situation country origin absence family financial social support motherhood child care influence professional life often interrupted abandoned attempt respond towards reconciliations dilemmas women legitimizing submission culminates normative position asymmetric practices subject consequently strengthening inequality scheme thus conclude political economical power receiving country aggravates feminization traditional gender roles see unequal achievement women relative men professional family spaces
humoral cellular immune responses play important role giardia lamblia infection several giardia proteins identified immunogenic antigens based elicited humoral immune response poorly known giardia antigens stimulate cellular immune response main purpose study isolate partial characterize immunogenic antigen lamblia protein isolated lamblia trophozoite lysates affinity chromatography using moab coupled cnbr sepharose isolated protein analysed electrospray tandem mass spectrometry esi diverse bioinformatics tools giardiadb blastn blastp expasy additionally several biochemical immunological characteristics isolated protein analysed esi amino acidic sequence deduced antigen belongs vsp family proteins lamblia protein composed one polypeptide chain kda using algorithm syfpheiti identified candidate cell epitopes antigen elicit cell mediated immune responses study identified lamblia protein induces strong immune response infected mice biochemical immunological characterization immunogenic antigen may contribute rational design giardia vaccine elsevier rights reserved
control systems proven beneficial improving productivity earthmoving operations main component systems monitoring module computer vision algorithms among new methods tested real time monitoring earthwork activities methods however able detect intraclass equipment failed identify individual machines key disadvantage compared radio based devices namely global positioning systems gps address issue pipeline framework consisting several computer vision algorithms developed identify individual machines framework object detection method used locate construction equipment detection view target obtained camera zooms candidate identify visual markers attached machine architecture system optimized employing time consuming processes probable candidates system evaluated using several real time videos demonstrated promising performance identifying excavators dump trucks identification rates recall rates respectively addition applying marker based verification step proved effective rejecting false alarms precision test cases american society civil engineers
childhood maltreatment major risk factor psychopathology also associated alterations network architecture brain hypothesized may play significant role development psychopathology study analyzed global network architecture physically healthy unmedicated year old subjects using diffusion tensor imaging dti mri tractography anatomical networks constructed fiber streams interconnecting cortical subcortical regions subjects low versus moderate high exposure maltreatment graph theory analysis revealed lower degree strength global efficiency maximum laplacian spectra higher pathlength smallworldness laplacian skewness less deviation artificial networks subjects moderate high exposure maltreatment balance local clustering similar groups different clusters strongly interconnected low exposure group history major depression anxiety attention deficit hyperactivity disorder significant impact global network measures effect maltreatment maltreatment important factor needs taken account studies examining relationship network differences psychopathology
analysis economic implications innovative business models networked environments electro mobility requires global approach ensure involved actors obtain benefit although electric vehicles evs provide benefits society whole number hurdles widespread adoption mainly high investment cost infrastructure therefore sound business model must built charging service operators allows recover costs time offer users charging price makes electro mobility comparable internal combustion engine vehicles purpose three scenarios defined present different charging alternatives terms charging power charging station ownership accessibility case study presented scenario required charging station usage profitable business model calculated demonstrate private home charging likely preferred option users charge home offers lower total cost ownership certain conditions even today contrary finding profitable business case fast charging requires intensive infrastructure usage elsevier ltd rights reserved
augmented reality allows add virtual object real scene increasing interest last years since mobile device becomes performant cheap augmented reality used different domains like maintenance training education entertainment medicine demonstrator show focused maintenance operations step step process presented operator order maintain element system based demonstration explain modelling propose allowing describing entire maintenance process augmented reality indeed still difficult creating augmented reality application without computer programming skills proposed model allow create authoring tool plug existing one order create augmented reality process without deep computer programming skills
usually commercial control solutions superheat control still use pid controllers standard although several applications advanced control refrigeration processes literature consensus optimal control solution system implementation advanced control algorithms ultimately depends accurate process knowledge form dynamic mathematical models study aims take first step toward designing adaptive stochastic mpc controller superheat control refrigeration cycle electronic expansion valve developing stochastic dynamic models process time varying time invariant versions models identified statistical validation results show whitening residuals time invariant models creating basis comparison recursive estimation time varying parameters realized kalman filter forgetting factor algorithms results validation tests simulation show good results average output errors degrees indicating armax time varying parameters may good presentation system elsevier ltd iir rights reserved
background studies shown recent upsurge human immunodeficiency virus hiv burden among men sex men msm china especially urban areas intervention planning resource allocation spatial analyses hiv aids case clusters required identify epidemic foci trends among msm china methods information regarding msm recorded hiv aids cases extracted national case reporting system demographic trends determined cochran armitage trend tests distribution case clusters examined using spatial autocorrelation spatial temporal scan used detect disease clustering spatial correlations cases socioenvironmental factors determined spatial regression results china hiv aids cases identified among msm newly identified hiv aids cases among self reported msm increased cases cases among hiv aids cases recorded years old aged years based clusters hiv aids cases identified spatial analysis epidemic concentrated among msm large cities spatial temporal clusters contained municipalities provincial capitals main cities beijing shanghai chongqing chengdu guangzhou spatial regression analysis showed sociodemographic indicators population density per capita gross domestic product number county level medical institutions statistically significant positive correlations hiv aids among msm conclusions assorted spatial analyses revealed increasingly concentrated hiv epidemic among young msm chinese cities calling targeted health education intensive interventions early age
purpose project test structural equation model self efficacy self care health behaviors modifiable risk factors predict quality life qol individuals coronary artery disease methods data set intervention study patients coronary artery disease intervention included secondary analysis study following parameters measured self efficacy self care health behaviors subscales health responsibility exercise consumption healthy diet stress management smoking cessation modifiable risk score qol assessed using item short form health survey instrument results mean age participants years following evaluation parameters indicated proposed model provided good fit data comparative fit index goodness fit index adjusted goodness fit index standardized root mean square residual root mean square error estimation confidence interval self efficacy self care health behaviors modifiable risk factors significant effects qol explained variance modifiable risk factors mediating self care health behaviors qol conclusions findings indicate self efficacy self care health behaviors modifiable risk factors play important role qol adults coronary artery disease patients could confident performing self care health behaviors leading better qol effectively managing cardiovascular risk factors nursing strategies improve qol population include motivating perform self care health behaviors copyright korean society nursing science published elsevier open access article license
study objective prevalence anesthesiology department wellness programs unknown database wellness programs needed resource departments attempting respond accreditation council graduate medical education anesthesiology milestones project purpose study survey academic anesthesiology chairs wellness issues characterize initiatives establish wellness contacts wellness initiative database wid design internet based survey instrument distributed academic anesthesiology department chairs united states setting line patients none interventions none measurements analysis continuous variables used standard means modes averages individual responses confidence intervals proportions calculated wilson method main results seventy five responses potential programs obtained forty one responders expressed interest participating wid provided contact information recently referred staff counseling wellness resources yet many respectively never surveyed department interest wellness resources thirty four percent wellness resources repository wellness topics garnered strong interest respondents addiction counseling sleep hygiene peer support program stress management conflict management burnout counseling time management dealing adverse events training statistically significant difference interest willing participate wid across topics significant difference based need recent staff referral conclusions majority chairs needed recently refer department member wellness resources counseling interested participating wid whereas minority gauged staff interest wellness topics wellness resource repository highest interest topics related function anesthesiologist willing participate database statistically significant differences interest across wellness topics elsevier inc rights reserved
backgroundnocturia one commonest nonmotor symptoms parkinson disease significant impact quality life patients carers exists relation nocturia poor sleep quality falls institutionalization nocturia may manifest result reduced functional bladder capacity nocturnal polyuria however often cause multifactorial disorders circadian rhythm regulation known occur sleep disturbances may also contribute nocturia methods resultsin review overview assessment management nocturia patients presented history taking medication review bladder diary form cornerstone evaluation urinalysis ultrasonography urodynamic studies help assess cause lower urinary tract symptoms exclude concomitant pathologies bladder outlet obstruction antimuscarinic medications first line treatment overactive bladder however caution needed using medications individuals predisposed cognitive impairment desmopressin effective managing nocturnal polyuria conclusionsan individualized approach recommended optimize management nocturia
study presents robustness design infinity fuzzy control nonlinear multiple time delay nmtd systems first neural network model constructed nmtd plant dynamics model converted linear differential inclusion ldi state space representation next terms lyapunov direct method delay dependent stability criterion derived guarantee stability nmtd systems subsequently stability condition criterion reformulated linear matrix inequality lmi based lmi fuzzy controller synthesized stabilize nmtd system achieve infinity control performance time designed infinity fuzzy controller stabilize nmtd system high frequency signal commonly referred dither simultaneously introduced stabilize dither frequency high enough output dithered system corresponding mathematical model relaxed system made close desired makes possible obtain rigorous prediction stability dithered system based one relaxed system finally numerical example simulations provided illustrate concepts discussed throughout paper
chronic diarrhea common problem affecting population given time patients vary definition diarrhea citing loose stool consistency increased frequency urgency bowel movements incontinence key symptoms physicians used increased frequency defecation increased stool weight major criteria distinguish acute diarrhea often due self limited acute infections chronic diarrhea broader differential diagnosis duration symptoms weeks frequently used cutoff symptom clusters settings used assess likelihood particular causes diarrhea irritable bowel syndrome distinguished causes chronic diarrhea presence pain peaks defecation relieved defecation associated changes stool form frequency rome criteria patients chronic diarrhea usually need evaluation history physical examination may sufficient direct therapy example diet medications surgery radiation therapy important causes chronic diarrhea suspected basis history alone testing indicated alarm features present obvious cause evident differential diagnosis needs delineation testing blood stool endoscopy imaging studies histology physiological testing roles play needed every patient categorizing patients limited testing may allow directed testing rapid diagnosis empiric antidiarrheal therapy used mitigate symptoms patients specific treatment available
study considers fluid dynamics arterial network model vessels developed assimilate vivo temporal data pressure area dynamics individual vessel segments male merino sheep model used estimate vessel wall parameters two parameter elastic model four parameter kelvin viscoelastic model done using nonlinear optimization minimizing least squares error model predictions measured cross sectional areas subsequently estimated values elastic stiffness unstressed area related construct nonlinear relationship relation used network model single vessel model aorta developed used estimate inflow profile parameters total resistance compliance downstream network demonstrate effects incorporating viscoelasticity arterial wall lastly extent vessel wall parameters estimated vivo data used realistically simulate pressure area vessel network evaluated elastic wall parameters network simulations found yield pressure area relationships across vessel locations sheep ranges comparable vivo data
case report describes novel technique restoring endodontically treated teeth hidden caries causing irreversible pulpitis mandibular molar radix entomolaris evident intact occlusal surface anatomy duplicated preparing access cavity replicate original occlusal surface post endodontic restoration using computer aided design computer aided manufacturing cad cam technique report highlights uniquely designed onlay utilizing benefits contemporary materials advanced technology
pathological gambling alongside addictive antisocial disorders forms part broad psychopathological spectrum externalizing disorders share underlying genetic vulnerability shared externalizing propensity highly heritable continuously varying trait disinhibitory personality traits impulsivity novelty seeking function indicators broad shared externalizing tendency may reflect neurobiological level variation reactivity dopaminergic daergic brain reward systems centered ventral striatum examined whether individual differences ventral striatal dopamine synthesis capacity associated individual variation disinhibitory personality traits twelve healthy male volunteers underwent fluoro dopa fdopa positron emission tomography pet scanning measure striatal synthesis capacity completed measure disinhibited personality found levels ventral dorsal striatal synthesis capacity significantly correlated inter individual variation disinhibitory personality traits particularly propensity financial extravagance irresponsibility results consistent preclinical models behavioral disinhibition addiction proneness provide novel insights neurobiology personality based vulnerability pathological gambling externalizing disorders
review essay examines compares cultural sociological economic factors affecting changes family formation structure single person lifestyles based upon four new recent books topics andrew cherlin labor love lost isabel sawhill generation unbound jonathan last expect one expecting eric klinenberg going solo
handwriting commonly identified area weakness children autism spectrum disorder asd precise deficits fully characterised boys asd matched controls aged years completed simple digitised task objectively assess handwriting performance using advanced descriptive measures moderate large associations identified handwriting performance attention asd symptoms motor proficiency asd group demonstrated significantly less smooth movements significantly greater sizing variability peak velocity relative controls findings provide clearer indication specific nature handwriting impairments children asd suggest relationship core clinical symptom severity attention motor behaviours
problem stochastic system identification utilizing response measurements considered paper negative log likelihood function utilized determine posterior probable parameters associated uncertainties formulated incorporating transmissibility matrix concept random matrix theory bayes theorem numerically iterative coupled method involving optimization parameters groups proposed reduce dimension numerical optimization problem involved initial guess parameters optimized also properly estimated asymptotic analysis one novel feature proposed method avoid repeated time consuming evaluation determinant inverse covariance matrix optimization due exploring statistical properties trace wishart matrix proposed method requires information model external input theory described work illustrated synthetic data field data measured laboratory model installed wireless sensors
repeatedly passing signal low pass filter may resemble using gaussian hyper gaussian filter conditions established resemblance theorem approximation gaussian hyper gaussian filters cascade simple filters established corresponding phase group delay characteristics analyzed theorem analysis exemplified cascading moving average filters first order butterworth filters
downsizing turbocharging today considered effective way reduce emissions automotive gasoline engines aim deep knowledge turbocharger behavior could key solution improve engine turbocharger matching calculation influence intake system geometry surge line position important aspect guide project intake manifold enlarging compressor stable zone aspect considerable impact engine performance especially transient operation wide experimental investigation carried turbocharger test facility university genoa small turbocharger compressor compressor characteristic curves measured considering automotive intake circuit compared standard maps provided turbocharger manufacturer information allows optimization model implementing realistic maps compressor influence three different layouts investigated varying overall circuit volume length keeping values range compatible passenger cars packaging constraints paper main results experimental campaign presented taking account influence geometry variations compressor map surge line position authors published elsevier ltd
october following period heavy rainfall landslide occurred calatabiano municipality sicily island southern italy causing rupture water pipeline supplying water city messina following event approximately inhabitants city suffered critical water shortages several days consequently november state emergency declared national italian department civil protection dpc emergency management phase provisional pass consisting three long pipes passing landslide area constructed restore water city furthermore november landslide remote sensing monitoring system installed following purposes analyse landslide geomorphological kinematic features order assess residual landslide risk support early warning procedures needed ensure safety personnel involved pass construction landslide stabilization works monitoring system based combined use ground based interferometric synthetic aperture radar insar terrestrial laser scanning tls work preliminary results monitoring activities remote map landslide area presented
provincial government ontario canada introduced new play based learning curriculum educational stakeholders teachers early childhood educators student teachers charged task implementing play based curriculum upholds children fundamental right play means health well paper examine educator experiences new play based curriculum toronto canada largest city found play based curriculum championed respect health well educational policy many challenges integrating play teaching practices especially era standardized testing conclude benefits play based learning children health important investigate whether current iterations play based curricula new pedagogical site governing children bodies whether play based curricula allow children experience engage pleasure ambiguities play daily lives schools
purpose case novel traditional laboratory markers successfully used determine surgical intervention timing elderly patient receiving dabigatran atrial fibrillation reported summary year old woman taking dabigatran atrial fibrillation suffered right femoral neck fracture requiring surgical intervention dabigatran withheld patient admitted hospital pharmacy inpatient anticoagulation management team consulted guidance determining appropriate scheduling surgical intervention regard time since recent dabigatran dose minimize bleeding complications team recommended delaying surgery dabigatran clearance would likely take days ecarin chromogenic assay eca dabigatran value would desirable surgical intervention hospitalization novel traditional laboratory markers dabigatran eca value activated partial thromboplastin time thrombin time prothrombin time measured followed closely determine best time perform surgical intervention minimize bleeding risk renal dysfunction likely delayed dabigatran elimination patient may led potential accumulation dabigatran patient ultimately wait days last dabigatran dose surgical intervention conclusion coagulation assay monitoring dabigatran emphasis eca dabigatran concentration used assess safety regarding bleeding risk nonemergent surgical procedure year old woman right femoral neck fracture
despite latino youth increased risk developing mental health problems less likely receive adequate treatment gonzales handbook latino psychology developmental community based perspectives sage thousand oaks romero ethn health smokowski community psychol flores pediatrics better understanding factors influence psychosocial outcomes latino youth crucial addressing existing mental health disparities order build existing knowledge factors promote positive mental health outcomes latino youth current study examined sociocultural influences latino early adolescents global self worth particular researchers investigated effects acculturation acculturation risk factors early adolescents perceptions global self worth seventy nine latino early adolescents completed series questionnaires assessing behavioral cognitive aspects acculturation ethnic culture origin mainstream culture biculturalism acculturation risk factors acculturation stress acculturation conflict perceived ethnic discrimination global self worth results suggested specific cultural orientations associated increased global self worth increased levels acculturation risk factors associated decreased global self worth acculturation conflict salient predictor global self worth regression analyses indicated effects acculturation stress acculturation conflict perceived ethnic discrimination global self worth depended youth cultural orientation behavioral cognitive measures acculturation results indicate importance assessing cognitive behavioral aspects acculturation well way acculturation moderates relation acculturation risk factors early adolescents perceptions global self worth
introduction cardiovascular risk cvr assessment management patients inflammatory arthritis recommended european nurses involvement role well studied aim aim present study explore european nurses role assessing managing cvr order suggest topics practice development research area regarding persons methods searched embase cinahl cochrane psycinfo pubmed databases included european articles past ten years described nurses assess manage cvr addition systematic review provided case studies five different countries illustrate national guidelines nurses role regarding cvr assessment management patients results thirty three articles included found trained nurses undertaking cvr assessment management different settings groups patients assessments include blood pressure body mass index waist circumference glucose lipid profile adherence medication behavioural risk factors unhealthy diet physical inactivity alcohol smoking different tools used calculate patients risk risk management differed brief advice long term follow nurses tended take holistic individually tailored approach clinical examples inclusion rheumatology nurses tasks scarce conclusion nurses undertake cvr assessment communication management different types patients considered highly relevant task rheumatology nursing especially patients studies needed assess patients perspective effectiveness cost effectiveness nurse led cvr copyright john wiley sons ltd
objective goal quantify television viewing day care settings investigate characteristics programs predict viewing methods telephone survey licensed child care programs michigan washington florida massachusetts performed frequency quantity television viewing infants toddlers preschool aged children assessed results exception infants children home based child care programs exposed significantly television average day children center based programs infants hours toddlers hours preschool aged children hours regression analysis daily television time preschool aged children child care center based programs found average fewer hours television day controlling covariates significant effect modi cation found impact home based versus center based child care programs differed somewhat depending educational levels staff members year college degree associated fewer hours television per day home based programs impact staff education television use observed center based programs conclusions many children previous estimates screen time significantly underestimated actual amounts pediatricians council parents minimize screen time child care settings pediatrics
development autoimmunity autoimmune diseases multifactorial vitamin one factors might play role postulated presence adjuvants insufficient levels vitamin may result development autoimmunity patients autoimmune inflammatory syndrome induced adjuvants asia relation silicone implant incompatibility measured vitamin levels patients asia relation silicone implant incompatibility related findings presence autoantibodies commonly used diagnose systemic autoimmune diseases furthermore systematically reviewed literature regarding vitamin deficiency risk factor development autoantibodies vitamin measurements available analysis patients asia relation siis twenty three patients tested positive autoantibodies patients either vitamin deficiency insufficiency median vitamin level mmol whereas five patients sufficient vitamin levels risk develop autoantibodies significantly increased vitamin deficient insufficient patients reviewed literature suggested association vitamin levels presence titer levels autoantibodies different autoimmune diseases current study review literature conclude vitamin deficiency related presence autoantibodies whether vitamin supplementation results decrease autoimmunity needs studied prospectively
amplitude candidate endophenotype disinhibitory psychopathology psychosis disorders present study comprehensive analysis behavioral molecular genetic basis amplitude genetic factor score large community sample adolescent twins parents genotyped single nucleotide polymorphisms snps biometric models indicated much variance measure due additive genes snps aggregate accounted approximately heritable variance however analyses individual snps yield significant associations analyses individual genes confirm previous associations amplitude candidate genes yield novel association myelin expression factor myef main effects individual variants may small detected gwas without larger samples
ginsenoside bioactive constituent isolated panax ginseng exhibits antitumorigenic antioxidative antiangiogenic neuroprotective biological activities associated regulation multiple genes dna methylation patterns particularly promoter region affect gene expression dna methylation catalyzed dna methylases however whether ginsenoside affects dna methylation unknown high performance liquid chromatography assay mspi hpaii polymerase chain reaction pcr reverse transcription quantitative pcr performed assess dna methylation demonstrated ginsenoside treatment resulted increased inhibition cell growth compared treatment ginsenoside human hepg hepatocarcinoma cell line additionally revealed treatment ginsenoside reduced global genomic dna methylation altered cystosine methylation promoter regions cell lymphoma vascular endothelial growth factor downregulated expression dna methyltransferase dnmt dnmtb treatment ginsenoside hepg cells results revealed modulation dna methylation may important pharmaceutical activities ginsenoside
water pollution resulting toxic organic pollutants become global issue identification suitable low cost non toxic material possessing catalytic behavior indispensable order circumvent enigma solving problem herein report quick cost effective surfactant free microwave assisted route preparation hexagonal wurtzite zno nanostructures photocatalytic performances structural morphological compositional aspects nanostructures determined various characterization techniques photocatalytic efficacies samples monitored induced degradation aqueous rhodamine rhb solution indicated nanostructures high photocatalytic capability superior performance many existing reports highest photocataytic efficiency obtained sample prepared min efficiency three cycles experiment rate constant possible mechanism growth zno nanostructures photo degradation also reported elsevier ltd rights reserved
understanding enhance cooperation coordination distributed open dynamic multiagent systems grand challenge across disciplines knowledge employed systems often limited heuristic nature cooperation promoting mechanisms based trust reputation become largely unreliable although recent studies within context tag based systems reported emergence stable cooperation uncertain environments limited exclusively static interaction structures consequently remains unknown whether conditions tag based interactions promote cooperation dynamic mobile systems herein combine methods game theory evolutionary computing agent based simulation study emergence tag mediated cooperation mobile network resource diversity series extensive monte carlo simulations find tag based interactions give rise high levels cooperation even presence different types contingent mobility model reveals agent migrations within system invasion new agents outside similar effects evolution dominant strategies interestingly enough observe previously unreported coexistence conditional unconditional strategies tag based model costly migrations contrast earlier studies show mobility driven strategy coexistence model affected resource limitations game specific factors findings highlight striking robustness tag based cooperation different mobility regimes important consequences future design cooperation enforcing protocols large scale decentralized self organizing systems peer peer mobile hoc networks elsevier rights reserved
time domain simulations heavily used today planning operation practices assess power system transient stability posttransient voltage frequency profiles well oscillatory behavior following severe contingencies comply industry standards increased modeling complexity many times slower real time state art commercial software packages complete dynamic simulation large scale model growing stochastic behavior introduced emerging technologies power industry seen growing need performing security assessment real time paper presents innovative parallel implementation framework speed single dynamic simulation leveraging existing stability model library commercial tools application programming interfaces apis several high performance computing hpc techniques explored implemented parallelizing calculation generator current injection identifying fast linear solvers network solution parallelizing data outputs interacting apis commercial package tsat proposed method tested western electricity coordinating council wecc planning base case detailed synchronous generator models exhibits outstanding scalable performance sufficient accuracy
theories neuroaesthetics assume looking traces actions used creating artwork brush marks associated simulation actions observer sensorimotor cortex aim current study dissociate activation sensorimotor cortex observation action traces associated visual processes twenty eight participants observed handmade graphics acrylic paint paper different complexity line triangle shape house computer generated counterparts central activity index sensorimotor cortex activity occipital alpha activity index visual cortex activity recorded eeg band line hyphesis activity electrode sensitive complexity handmade computer generated graphics contrast occipital alpha activity sensitive complexity handmade computer generated graphics furthermore empathic participants rated stronger suppression induced handmade graphics compared computer generated graphics electrode results support involvement sensorimotor cortex recognition action traces strengthen evidence individuals scoring high emotional empathy feature particularly responsive mirror neuron system elsevier rights reserved
compound files information hiding technology become hot research topic field information security paper proposes information hiding method compound files based structured storage method employing compound file principle structured storage vsto visual studio tools office plug mechanism specific data including user name machine name address date time etc stored compound documents detected naked eyes experiment results show proposed method store large amount data microsoft office files internal structure higher efficiency easier implementation fewer time consuming
fractional order pid fopid controllers introducedas general form classical pid controllers using fractional calculus controller provides good disturbance rejection robust plant uncertainties appropriate vibration mitigation structures paper fopid controller designed adjust contact force piezoelectric friction dampers semi active control base isolated structures far field near field earthquake excitations multi objective cuckoo search algorithm employed tune controller parameters considering resulting pareto optimal front best input fopid controller selected seven pairs earthquakes nine performance indices performance proposed controller compared provided several wellknown control techniques according simulation results proposed controller performs better controllers terms simultaneous reduction maximum base displacement story acceleration various types earthquakes also provides acceptable responses terms inter story drifts root mean square base displacements floor acceleration addition evaluation robustness stiffness uncertainty indicates proposed controller gives robust performance modeling errors isa published elsevier ltd rights reserved
multimodal vibration reduction obtained coupling mechanical structure electrical network approximating modal properties strategy applied control clamped plate network passive electrical components plate network coupled periodic array piezoelectric patches enables energy conversion network experimentally implemented inductors transformers order create electrical resonances present spatial distribution approaching first mode shapes plate tuning electrical resonances mechanical ones becomes possible introduce equivalent tuned mass effect effect occurs electrical mechanical mode shapes sufficiently close requires specific network topology boundary conditions network tuned adding resistors introduces damping lead broadband vibration reduction plate thus shown control implemented purely passive solution could great interest many embedded applications
following thyroid surgery levothyroxine therapy used replace deficient thyroid hormones prevent postoperative thyroid hypofunction compared effects replacement therapy either liquid tablet formulation levothyroxine mood states self perceived mental well thyroid hormone profile recently thyroidectomized patients profile mood states general heath questionnaire items thyroid hormone profile assessed recently days thyroidectomized patients baseline months randomization replacement therapy either liquid tablet formulation levothyroxine months levothyroxine replacement treatment significant improvements positive affect scale negative affect scale profile mood states well general heath questionnaire items observed study population however greater variations observed patients assigned liquid levothyroxine formulation comparison assigned levothyroxine form tablet time treatment interaction positive affect scale profile mood states negative affect scale profile mood states general heath questionnaire items expected circulating tsh levels significantly decreased levels significantly increased levothyroxine replacement therapy changes significantly greater patients treated liquid levothyroxine formulation time treatment interaction tsh data indicate greater efficacy liquid formulation levothyroxine ameliorating mood states self perception mental well thyroid hormone profile months replacement therapy recently thyroidectomized patients
research investigated method optimize start performance dimmable light emitting diode led driver based half bridge class series parallel lcc topology led driver designed outdoor high bay applications input voltage total maximum output power wide tunable output current range wide load range makes difficult achieve startup time less load condition well limit output overshoot level implementing one set values feedback loop moreover design fluorescent control used due cost efficiency repurposing existing fluorescent ballast manufacturing systems start sequence fluorescent control introduces additional challenge start design order comply energy star requires output current reach nominal value also limit overshoot level self adjusted duty cycle control algorithm designed duty cycle signal generated measuring load condition secondary side microcontroller used determine switching frequency lcc tank method start performance greatly improved meets requirements
electrical circuits based linear nonlinear modelling principles difficulties meet demands caused large amount data generated processed aim examine existing models bigeometric calculus point view obtain accuracy results work application bigeometric runge kutta brk method aiming solve differential equations nonzero initial condition type work arises applications systems defined ordinary differential equations noise filter audio chaotic circuits etc solutions types equations always easy improvement work obtained introducing bigeometric calculus process seeking solution differential equations different classes input signals applied input system processed determine accuracy output applicability tested classical method called runge kutta simulation results confirm application brk method electrical circuit analysis new method also provides better results types input signals linear nonlinear constant gaussian
paper investigates impact stock market developments oil electricity demand oecd member countries conduct different panel data methodologies use annual data ranging overall findings substantiate income real prices size stock market liquidity important determinants oil electricity demand also compute long run elasticity coefficients using simple partial adjustment model pam find long run elasticity coefficients larger short run parameters moreover results show demand oil electricity inelastic respect real price real income short run long run policy making perspective findings suggest potential policy tools reduce energy consumption may useful demand energy inelastic respect energy prices results also manifest although stock market deepening variables large effect energy use energy price economic growth market size liquidity significantly affect energy consumption therefore energy demand estimations based solely energy price income may inaccurate stock market development indicators excluded empirical findings paper provide insights policy makers energy companies energy economists terms demand management policies pricing decisions
objective study undertaken determine occurrence rates outcomes risk factors timing obstetric delivery trauma sustained pregnancy study design retrospective cohort study women trauma california international classification disease ninth revision clinical modification codes external causation codes injury identified maternal fetal neonatal outcomes analyzed women delivering trauma hospitalization group women sustaining trauma prenatally group compared nontrauma controls injury severity scores injury types used stratify risk relation outcome statistical comparisons expressed odds ratios ors cis results total deliveries fulfilling study criteria identified total deliveries fractures dislocations sprains strains common type injury group associated worst outcomes maternal death fetal death uterine rupture placental abruption group also resulted increased risks delivery placental abruption preterm labor maternal death injury severity scores increased outcomes worsened yet statistically nonpredictive type injury commonly leading maternal death internal injury risk fetal neonatal infant death strongly influenced gestational age time delivery conclusion women delivering trauma hospitalization group worst outcomes regardless severity injury group women prenatal injury increased risk adverse outcomes delivery therefore monitored closely subsequent course pregnancy study highlights need optimize education trauma prevention pregnancy elsevier inc rights reserved
role prediction error driving learning well established fields classical instrumental conditioning reward learning procedural memory however role human one shot declarative encoding less clear according one recent hypothesis reflects divergence two probability distributions one reflecting prior probability previous experiences reflecting sensory evidence current experience assuming unimodal probability distributions manipulated three ways distance mode prior evidence precision prior precision evidence tested three manipulations across five experiments terms peoples ability encode single presentation scene item pairing function previous exposures scene item memory probed presenting scene together three choices previously paired item two foil items pairings within condition target item experiment manipulated evidence either consistent inconsistent prior expectations predicting larger hence memory better new pairing inconsistent experiments manipulated precision priors predicting better memory new pairing inconsistent priors precise experiment manipulated visual noise prior exposure unfamiliar faces pairing scenes predicting better memory sensory evidence precise experiments hypotheses supported discuss alternative explanations individual experiments conclude predictive interactive multiple memory signals pimms framework provides parsimonious account full pattern results authors published elsevier inc open access article license
insomnia presents increasing significant health issue paediatric population problem grown past decade became recognised specialists dealing children adolescents recent study american academy child adolescent psychiatry members asked experience patients complaining sleep disturbances doctors reported sleep problem patients required pharmacotherapy multiple studies concerning adults confirmed significance healthy sleep optimal cognitive emotional social biological functioning adequate sleep important prophylaxis many chronic diseases obesity diabetes hypertension myocardial infarction stroke due increasing prevalence insomnia children adolescents growing attention paid short long term consequences group review summarises available data chronic insomnia prevalence consequences population years old
concern best way apply foldover technique resolution fraction often helpful consult literature available unfortunately foldover plans resolution designs factors provided article shows methodology selection classification foldover plans two level fractional factorial designs factors based exhaustive search computer programming recommended foldovers presented research extends current foldover plans available resolution designs copyright john wiley sons ltd
consider one applied global optimization problem set feasible solutions discrete large goal find optimal perfect gratings guarantee high quality security visual cryptography method priori estimation techniques branch bound type methods applied exclude essential part elements feasible set thus full search required solve global optimization problem exactly computationally demanding library templates developed allows user implement parallel master slave algorithms application without knowledge parallel programming api application programming interface design templates allows users build parallel solver using mpi message passing interface api distributed computing application using boinc berkeley open infrastructure network computing api code implementation application specific tasks build parallel distributed computing solvers considered optimization problem present results computational experiments using computer cluster boinc project volunteer computing heuristic methods also considered alternative full search algorithm due complicated conditions defining feasible solutions perfect gratings genetic algorithms used solve problem efficiently propose two memetic heuristic algorithms basic stochastic simplified full search algorithm combined local search algorithm parallel heuristic algorithms also proposed implemented efficiency accuracy heuristics investigated results experiments presented
extratropical cyclones key feature weather extratropics climate models need represent order provide reliable projections future climate extratropical cyclones produce significant precipitation associated latent heat release play major role development study evaluates ability climate model higem represent latent heating extratropical cyclones remote sensing data used investigate ability climate model era interim erai reanalysis represent extratropical cyclone cloud features latent heating assessed offline radiance simulator cosp isccp cloudsat datasets used evaluate comparable fields higem erai higem found exhibit biases cloud structure extratropical cyclones much high cloud produced warm conveyor belt region compared isccp significant latent heating occurs region derived primarily higem convection scheme erai also found exhibit biases cloud structure clouds lower altitudes observed isccp warm conveyor belt region result latent heat release erai concentrated lower altitudes cloudsat indicates much precipitation may produced low altitude higem erai particularly erai neither capture observed variability precipitation intensity potential vorticity structure composite extratropical cyclones higem erai also compared pronounced tropopause ridge evolves higem leading edge composite compared erai one future area research addressed impact biases representation latent heating climate projections produced higem biases found erai indicate caution required using reanalyses study cloud features precipitation processes extratropical cyclones using reanalysis evaluate climate models ability represent structure
available analytic solution considering suspender deformation given determine cable tension load middle cable suspender internal load suspension bridge firstly classical theory without suspender deformation taken study sag effect internal load suspension bridge results indicate tension load cable points decreases sag increases procedure using muller breslau principle determine moment shear force influence line stiffening girder wire suspension bridge given validated influence line given classical theory secondly new analytic solution considering suspender deformation given determine cable tension load midpoint internal load suspenders new analytic solution reasonable classical theory theory according new analytic solution cable tension load gets peak value unit live load applies middle stiffening girder internal tension loads suspenders reach equal maximum value linear static model built ansys ignoring large displacement initial strain ernst modulus elasticity results using new analytic solution compare well benchmark simulations ansys proposed analytic solution quick easy way approximately determine internal load small span suspension bridge
alternative approach layered sensing system systems methodology denoted lswr layered sensing radio outlined paper novel broadcast driven layered sensing technique shows potential finding embedded objects within example buildings via leveraging combining existing commercial satellite technologies cots commercial shelf wireless network technologies state art wireless sensor mote technologies specifically compact sensor mote technologies employed cost effective manner interface control low cost satellite radio broadcast tuners approach initial concepts type investigated via analysis compact custom sensor node technology wireless sensor mote interfaced satellite broadcast tuner integrated onto ugv unmanned ground vehicle robot arm purposes developing prototype ugv robot systems passive integrated sensors support example networked thru wall embedded object detection primary category commercial satellite signal considered analysis within paper known dvb digital video broadcast
liquid jet injector biomedical device intended drug delivery medication delivered fluid stream penetrates skin small diameter liquid stream created piston forcing fluid column nozzle devices powered springs compressed gas study cfd simulation carried investigate fluid mechanics performance needle free injectors powered specifically compressed air motion internal mechanisms injector propels liquid jet orifice simulated moving boundary method fluid dynamics modeled using les vof techniques paper numerical results discussed comparing fluid stagnation pressures liquid jet previously published experimental measurements obtained using custom built prototype air powered needle free liquid injector performance plots function various injector parameters presented explained
stagnation flow import research branch fluid mechanics describing fluid motion near stagnation region exists solid bodies moving fluid stagnation point boundary layer flow problems described partial differential equations attracted many scholars attention nowadays problems become difficult hot study applied mathematics mechanics materials engineering paper transformed governing boundary layer equations system nonlinear differential equations similarity transformation analytical approximations solutions derived homotopy analysis method ham addition effects physical factors slip parameter magnetic field parameter reynolds number flow examed discussed graphically great impact speed
work anxieties often going along workplace problems long term sick leave psychopathologically different qualities work anxiety distinguished worrying phobic anxiety health related anxiety anxiety insufficiency evaluation work anxiety treatment showed confronting patients topic work medical rehabilitation leads better course work oriented capacity trainings behavior therapy groups coping everyday phenomena work may trained self presentation social rules work organization problem solving coping chronic illness impairment conditions active coping communication explaining impairment supervisor occupational physician making problem solving possible helpful cases correction expectations must done normalizing everyday work problems conflicts achievement requirements normal work work make happy time
existing literature backorder eoq problem usually focuses business customer neglects impact batch demands backlogging behavior business business environment paper contributes formulating inventory problem wholesaler facing batch demands using backorder control inventory wholesaler non differentiable average cost function encompasses curtain like pattern based structural properties disclose optimality conditions backlogging ordering quantities using conditions efficient algorithms built search optimal policy discussion algorithm design separated two parts integer requirement ordering quantity practice convenient control inventory wholesaler ordering quantity exactly integer multiple customer demanding size integer requirement exists closed form solution provided answer optimal ordering quantity elsevier inc rights reserved
studies relation psychopathy cognitive functioning often show mixed results partially different factors psychopathy considered fully based previous research predicted divergent results based factor model psychopathy interpersonal affective traits impulsive antisocial traits specifically predicted unique variance interpersonal affective traits would related increased monitoring error related negativity adjusting errors posterror slowing whereas impulsive antisocial traits would related reductions processes three studies using diverse selection assessment tools samples methods presented identify response monitoring correlates main factors psychopathy studies undergraduates adolescents offenders interpersonal affective traits related increased adjustment following errors study enhanced monitoring errors impulsive antisocial traits consistently related error adjustment across studies although traits related deficient monitoring errors study results may help explain previous mixed findings advance implications etiological models psychopathy
water quality banchengzi reservoir beijing deteriorating year year embodied increasing concentrations cod stable high levels total nitrogen order identify causes formulate strategy pollution prevention control examined temporal spatial variations water pollution carried source identification studies routine monthly monitoring data seven water quality six hydro meteorological variables banchengzi reservoir analyzed statistical techniques including correlation analysis principle component analysis addition water samples six different sites reservoir collected analyzed investigate spatial variation water quality identify water pollution sources vis spectroscopy three dimensional excitation emission matrix spectroscopy nitrogen stable isotope analysis results revealed dissolved organic matter nitrogen main pollutants principally derived anthropogenic point source pollution upper areas included domestic sewage livestock farming speculated biodegradable organic pollutants sewage degraded form soluble microbial products smp aerobic microorganisms nitrogen pollutants mostly transformed nitrate nitrification smp nitrate refractory pollutants carried upper stream flowing banchengzi reservoir accumulated effective control point source pollution upper river ecological restoration done improve water quality protect reservoir
phenotype cyclin dependent kinase like cdkl syndrome includes rett syndrome variant early onset seizures early onset epileptic encephalopathy severe developmental delay autistic features often reported literature detailed reports behavior individuals lacking describe clinical picture girl aged years months affected cdkl syndrome special attention neurobehavioral phenotype evaluation showed apart profound intellectual disability presence atypical features behavior mainly relating people imitation verbal nonverbal communication thus justifying diagnosis comorbid autism spectrum disorder formal assessment behavior appropriate tools necessary choose appropriate rehabilitative intervention characterize detail cdkl syndrome phenotype propose testing protocol neurobehavioral assessment patients
current research purpose measure effect ethnocentrism estonian consumers buying behavior skin care products category consumer ethnocentrism measured cetscale questionnaire carried sample respondents consumers tend buy foreign skin care products estonia consumers consider purchasing locally manufactured products important buying foreign goods wrong irresponsible consumers high level ethnocentrism level higher prefer buy skin care products domestic origin current survey provides several suggestions market skin care products estonia authors published elsevier ltd
background short syndrome rare genetic congenital defects condition frequency disease still remains unknown case presentation report two year four month old female short syndrome present growth retardation dysmorphic features triangular shaped face prominent forehead ocular depression lipodystrophy lumbar region around elbows consistent phenotype described syndrome molecular analysis showed presence heterozygous variant dupt lys exon pikr conclusions frequency disease still remains unknown solely several dozen cases described worldwide
studies variety species reported enhanced prosocial effects acute administration neuromodulating hormone oxytocin although exact mechanisms underlying effects fully understood broad interest developing treatment social deficits studies however examined effects given repeatedly early development period early intervention likely greatest benefits reversing progression towards social impairment studies exclusively rodents report mixed results shown enhancement prosocial behavior including increased social exploration others shown antisocial effects including increased aggression present study infant rhesus macaques treated high frequency per week low frequency per week dose intranasal oxytocin placebo saline two six months age reactions dynamic facial expressions neutral lipsmacking threats measured results showed compared placebo increased time monkeys spent viewing expression videos selectively reduced attention eyes neutral faces dose dependent manner mechanism non prosocial effect may repeated administration regulates expression receptors brain regions important regulating social attention consequently results raise questions efficacy implementing chronic pharmacotherapy treatment social deficits particularly given early development work needed identify optimal treatment schedules also understand exerts influences brain behavior elsevier ltd rights reserved
objectives identify relationship temperature variation neighbouring days tvn hospital visits childhood asthma age sex specific groups study design ecological design used explore effect tvn hospital visits childhood asthma methods poisson generalised linear regression model combined distributed lag non linear model used analyse association tvn hospital visits childhood asthma hospital visits childhood asthma june july included daily climate data obtained hefei meteorological bureau results significant correlation found tvn hospital visits childhood asthma age sex specific groups different gender groups effect tvn childhood asthma greatest days lag males females different age groups effect tvn childhood asthma greatest days lag years years children respectively degrees increase tvn associated confidence interval increase hospital visits childhood asthma conclusions tvn associated hospital visits childhood asthma temperature change rapidly guardians urged pay attention children health may reduce morbidity childhood asthma royal society public health published elsevier ltd rights reserved
meet current diesel engine pollutant legislation important manage treatment devices paper describes development neural network based virtual sensors used estimate nox emissions exhaust automotive diesel engines suitable identification methodologies experimental tests developed aim meeting conflicting needs feasible board implementation satisfactory prediction accuracy addition since prediction control oriented models typically affected engine aging production spread well components drift least square technique features exploited order overcome issues adapting virtual sensor output nox adaptive virtual sensor tested via comparison experimental data measured engine test bench turbocharged common rail automotive diesel engine furthermore besides model validation experimental measurements modified simulate sensor drift order enable full assessment proposed based algorithm adaptation capabilities
first study ascertain value multidisciplinary team mdt meetings within early pregnancy assessment unit epau national telephone survey identified united kingdom overall epau utilise regular mdt meetings secondary tertiary hospitals likely hold regular mdt meetings participants interview study expressed principal benefits regular mdt meetings communication education effective stress management perceived additional benefits included improved care quality better patient experience enhanced team cohesion meetings least one representative every tier staffing present caseload mdt meeting comprised ectopic pregnancies pregnancies unknown location propose number research studies would build study efforts help enhance effectiveness mdt based epau service
present study analyzes mediator role work team trust horizontal trust relationship transformational leadership social resource team performance intra extra role performance suggested hero model healthy resilient organizations model salanova llorens cifre martinez sample corresponds workers nested work teams four organizations healthcare sector horizontal trust transformational leadership assessed work teams performance assessed supervisors teams structural equations models reveal expected horizontal trust fully mediating role transformational leadership perceived team level team performance assessed supervisor
part curriculum changes south africa introductory programming language scratch must first taught switching well established teaching delphi nature programming scratch considerably different delphi assumed teaching scratch introductory programming language could support learners understanding delphi teachers receive much training scratch study explores teachers experiences first year teaching scratch purpose research understand scratch used effectively transitioning language delphi deduce guidelines teaching scratch introduction object oriented programming delphi qualitative research method within interpretive paradigm selected research interviews done eight randomly selected information technology teachers province north west south africa gain insight experiences teaching scratch first year implementing new curriculum findings show teachers uncertain teach programming concepts integrate problem solving algorithm design teaching scratch focus teaching scratch instead teaching programming concepts scratch emerging guidelines emphasise integration problem solving algorithm design creation opportunities expose learners error handling program testing inculcatation programming concepts furthermore recommend active teaching learning strategies pair programming
objective examine effectiveness affect recognition interventions faces stories people traumatic brain injury setting postacute rehabilitation facilities participants total participants moderate severe traumatic brain injury screened eligible randomized faces stories control interventions participants average years age years postinjury participants male design randomized controlled trial immediate month month follow posttests interventions hours computer based training therapist measures diagnostic assessment nonverbal accuracy adult faces emotional inference stories test empathy interpersonal reactivity index irritability aggression neuropsychiatric inventory results faces intervention significantly better control intervention diagnostic assessment nonverbal accuracy adult faces posttreatment time effect group interaction observed significant differences noted faces intervention significant differences observed stories control interventions however significant time effect found emotional inference stories test conclusion faces intervention effectively improved facial affect recognition participants chronic post traumatic brain injury changes maintained months future work focus generalizing skill functional behaviors
acute kidney injury chronic kidney disease ckd lead diminished kidney function interdependent risk factors increased mortality untreated time end stage renal disease esrd inevitable outcome acute chronic kidney diseases occur partly due imbalance molecular mechanisms govern oxidative stress inflammation autophagy cell death oxidative stress refers cumulative effects highly reactive oxidizing molecules cause cellular damage autophagy removes damaged organelles protein aggregates pathogens recruiting substrates double membrane vesicles called autophagosomes subsequently fuse lysosomes mounting evidence suggests oxidative stress autophagy significantly involved kidney health disease however little known signaling processes link review focused understanding role oxidative stress autophagy kidney diseases review also discuss potential relationships oxidative stress autophagy may enable development better therapeutic intervention halt progression kidney disease promote repair resolution authors published elsevier
recent studies experienced use advanced tools smart aircraft maintenance inspection tools often require use computer vision based technologies recognize track given aircraft mechanical part order make possible show additional information technician suitable display paper propose visual recognition module aircraft mechanical parts included prototype system designed smart maintenance alenia aermacchi evaluation carried real aircrafts considers different kind maintenance operations require recognition different mechanical parts visual recognition module tested different imaging conditions varying scale orientation parts interest results confirm feasibility proposal also challenging realistic condition elsevier rights reserved
macromolecular immunosuppressive monoclonal antibodies fusion proteins directed molecules cells involved inflammation immunity represent recent important addition therapeutic armamentarium tumor necrosis alpha tnf cytokine involved systemic inflammation clinical utilization antagonists revolutionized treatment juvenile rheumatoid psoriatic arthritis ankylosing spondylitis crohn disease ulcerative colitis plaque psoriasis clinical utility also demonstrated use steroid refractory graft host disease immune mediated conditions currently five anti tnf agents approved european medicines agency ema including monoclonal anti tnf antibodies infliximab adalimumab golimumab certolizumab pegol along etanercept tnf receptor igg fusion protein theoretical considerations related mode action clinical observations suggest opportunistic infectious complications seriously considered possible adverse events macromolecular immunosuppressants purpose review critically analyze literature invasive fungal infections ifis occurring association tnf inhibitors alone combination immunosuppressive agents focus pediatric patients provide framework evaluating risk ifis population
bioactive lysophospholipid sphingosine phosphate best known activity cell active chemoattractant regulating egress cells lymph node consequently availability cells migration peripheral tissues physiological role exploited drug fingolimod first line therapy multiple sclerosis detains cells lymph nodes recent year elucidated exerts regulatory functions far beyond cell egress lymph node thus additionally regulates among others homing several immune cell populations peripheral tissues inflammatory conditions addition evidence mostly derived mouse models accumulated may involved pathogenesis several inflammatory skin disorder receptor modulators applied topically effective treating skin diseases recent developments highlight pharmacological modulation receptor system potential new therapeutic strategy plethora inflammatory skin diseases impact receptor modulation inflammatory skin diseases next requires testing human patients
aim study investigate effects dietary supplementation leucine redox status gene abundance relating mitochondrial biogenesis function jejunum intrauterine growth retarded iugr piglets early weaning period according factorial arrangement iugr normal body weight nbw piglets fed basal diet without leucine supplementation basal diet plus leucine supplementation age results showed compared nbw piglets iugr piglets lower jejunal dna concentration reduced manganese superoxide dismutase mnsod total antioxidant capability aoc activities mitochondrial dna content jejunum leucine supplementation increased mnsod aoc activities decreased malondialdehyde content jejunum iugr piglets mrna gene abundance nuclear respiratory factor nrf mitochondrial transcription factor tfam atp synthase atps cytochrome oxidase ccox cytochrome glucokinase jejunum iugr piglets reduced compared nbw piglets however nrf peroxisome proliferation activated receptor gamma coactivator alpha tfam atps ccox mrna gene abundance jejunum iugr piglets increased diets supplemented leucine data indicate leucine supplementation therapeutic potential attenuating intestinal oxidative stress mitochondrial dysfunction iugr piglets early period life via increasing enzyme activities regulating mrna gene abundance
parallel distributed computing led proliferation solving computationally intensive mathematical science engineering problems however computational environments often prone unpredictable variations due problem algorithm system characteristics therefore robustness study resource allocations application scheduling required guarantee desired level performance given initial workload mapping applications resources considered robust optimizes execution performance guarantees desired level performance presence unpredictable perturbations runtime research work stochastic process algebra performance evaluation process algebra used obtaining performance various resource allocations via numerical analysis performance modeling parallel execution applications parallel computing resources robustness analysis various allocations performed finding robust mapping set initial mapping schemes numerical results obtained performance modeling resource allocations validated simulation results earlier research available existing literature thus underscoring significance using stochastic process algebra models providing cost effective low overhead analysis robustness copyright john wiley sons ltd
batch adsorption experiments carried removal methylene blue cationic dye aqueous solution using organic inorganic hydrogel nanocomposite titania incorporated sodium alginate crosslinked polyacrylic acid poly tio hydrogel prepared graft copolymerization acrylic acid onto sodium alginate biopolymer presence crosslinking agent free radical initiator tio nanoparticles hydrogel exhibited high swelling capacity factors influencing adsorption capacity absorbents dye solutions initial concentration dye amount absorbents temperature investigated used propose possible mechanism adsorption adsorption process concurs pseudo second order kinetics langmuir isotherm equation high adsorption capacity max correlation coefficient calculated isotherm equations show high efficiency absorbent thus expected good candidate absorbent water treatment elsevier ltd rights reserved
objectivewe aimed study role attachment style headache severity psychological symptoms migraineurs children adolescents moreover investigated association attachment style migraine severity psychological symptoms backgroundattachment theory suggests early interpersonal relationships may important determinants psychopathology pain management particular individuals insecure attachment styles shown experience pain people secure attachment style studies focused headache data attachment style pediatric headache scarce methodswe studied migraineurs mean age years female male patients divided two groups according headache attack frequency high frequency patients weekly daily episodes low frequency patients showing episodes per month according headache attack intensity patients classified two groups mild pain allowing patient continue daily activities severe pain leading interruption patient activities forcing child bed psychological screening assessed safa anxiety depression somatization questionnaires attachment style measured semi projective test separation anxiety test patients divided secure avoidant ambivalent disorganized confused attachment patterns resultswe found significant relationship attachment style migraine features ambivalent attachment common style among patients reporting high attack frequency severe pain intensity anxiety safa tot depression safa tot somatization safa tot higher patients ambivalent attachment style moreover results showed association high attack frequency high anxiety levels children ambivalent attachment style conclusionsambivalent attachment style may common vulnerability factor impacts pain severity anxiety depression somatization symptoms young migraineurs particular present study provides first evidence role insecure attachment relationship pain severity psychological symptoms migraine children
new secure key distribution scheme based dynamic chaos synchronization two cascaded semiconductor laser systems cslss subject common chaotic injection random phase modulated optical feedback demonstrated scheme alice bob adopt two independent random sequences control phase modulators cslss induces dynamic perturbation chaos synchronization thoroughly investigate chaos synchronization performance different phase shift conditions cross correlation function systematically discuss feasibility security system results show proper injection feedback strength correlation coefficient gap phase shift match mismatch clear robust parameter mismatches cslss two cslss based high quality key distribution performed picking identical random bits two independent random sequences according computational correlation moreover investigations information theoretic security rate key distribution show security key distribution scheme enhanced properly increasing number layers cslss employing highorder modulation format
foaming followed drying potential methodology production crispy snacks especially restaurant catering level influence either freeze drying air drying physicochemical weight loss moisture content water activity instrumental colour instrumental texture structural scanning electron microscopy sem sensory features whipped yogurt foam studied air dried yogurt foams showed significantly higher water activity values freeze dried ones instrumental texture analysis foams significant lower maximum force hardness total number fracture events ones instrumental colour foams showed higher values lightness lower yellowness browning index sem images evidenced foams kept foamed structure structure ones totally collapsed sensory results indicated higher degree hardness crispness foams ones using different drying technologies dried foams tuned show completely different features elsevier ltd rights reserved
mutations xpd subunit dna repair transcription factor tfiih result distinct clinical entities including cancer prone xeroderma pigmentosum multisystem disorder trichothiodystrophy ttd share cutaneous photosensitivity gene expression profiles primary dermal fibroblasts revealed overexpression matrix metalloproteinase mmp gene encoding metalloproteinase degrades interstitial collagens extracellular matrix ecm ttd patients mutated xpd compared healthy parents defect observed ttd specific fibroblasts main producers dermal ecm mmp transcriptional regulation ttd caused erroneous signaling mediated retinoic acid receptors mmp promoter leads hypersecretion active mmp enzyme degradation collagen type ecm cell tissue systems ttd patient skin agreement well known role ecm eliciting signaling events controlling cell behavior tissue homeostasis ecm alterations ttd shown impact migration wound healing properties patient dermal fibroblasts presence specific inhibitor mmp activity sufficient restore normal cell migration thus providing potential approach therapeutic strategies study highlights relevance ecm anomalies ttd pathogenesis phenotypic differences ttd
daily changes light dark cycle principal environmental signal enables organisms synchronize internal biology hour day night cycle humans visual system integral photoentrainment primarily driven specialized class intrinsically photosensitive retinal ganglion cells iprgcs express photopigment melanopsin opn inner retina cells project retinohypothalamic tract rht suprachiasmatic nuclei scn hypothalamus serves body master biological clock time retina possesses intrinsic circadian oscillations exemplified diurnal fluctuations visual sensitivity neurotransmitter levels outer segment turnover rates recently noted central peripheral oscillators share molecular clock consisting endogenous circadian driven transcription translation feedback loop cycles periodicity approximately hours review cover role melanopsin iprgcs play circadian organization visual system
bone connective tissue gives body support stability mechanical terms bone nanocomposite material complex hierarchical structure contributes bone excellent mechanical properties including high stiffness strength fracture toughness light weight nanoscale cross linked collagen molecules hydroxyapatite nanocrystals water small amount non collagenous proteins ncps form mineralized collagen fibrils mcf mcf serves primary building block bone thus physical mechanical characterization critical finding structure property relations bone understanding bone overall behavior paper review composition structure mcf summarize existing models proposed literature predict effective elastic response models classified following four categories models based strength materials approach mainly variants voigt reuss bounds models originally proposed characterization composite materials however also applicable model mcf collagen composite models based micromechanics theories iii computational models involving mostly finite element method fem atomistic simulations using molecular dynamics types models advantages disadvantages strength materials models simpler mathematically involve approximate solutions micromechanics approaches usually involve simpler geometrical models solved rigorously computational models based mainly finite element method account precisely structural features bone including collagen arrangement collagen cross links collagen interphase simulations conducted atomic level small regions provide insights properties collagen molecules fibrils effect collagen cross linking collagen interphase serve inputs continuum based models paper outline representative models bone nanoscale mineralized collagen fibril discuss assumptions limitations drawbacks models present comparison offer recommendations future work area discussion help develop complete models mcf addressing physical mechanical biological aspects bone behavior nanoscale furthermore shed light designs collagen nanocomposites desired mechanical properties used biomaterials orthopedic applications surface coatings implant materials bone substitutes scaffolds bone tissue regeneration elsevier rights reserved
review analyzes trends commonalities among prominent theories media effects basis exemplary meta analyses media effects bibliometric studies well cited theories identify discuss five features media effects theories well empirical support features specifies conditions media may produce effects certain types individuals review ends discussion media effects newer media environments includes theories computer mediated communication development appears share similar pattern reformulation unidirectional receiver oriented views theories recognize transactional nature communication conclude outlining challenges promising avenues future research
ambivalent sexism served justify maintain patriarchy traditional gender roles characterized inequality male domination intimate partner violence ipv literature according moral foundation theory mft two specific moral foundations related inequality domination fairness authority connect separate fields arguing sexist attitudes related specific patterns endorsement five moral foundations hypothesis ambivalent sexism men convicted violence partner may rooted least two moral foundations least two moral foundations may also serve predict intention change violent behavior partner controlling political orientation results show benevolent sexism correlates positively authority foundation hostile sexism correlates negatively fairness foundation foundations contribute explaining two dimensions ambivalent sexism benevolent hostile fairness foundation predict intention change violent behavior partner new treatment approaches could designed increase moral concerns fairness reduce moral concerns authority people least used violence partners
year old man underwent abdominal computed tomography periodic follow following distal gastrectomy lymphadenectomy gastric cancer mucosal associated lymphoid tissue malt lymphoma conducted months earlier contrast enhanced demonstrated well circumscribed mass lesion heterogeneous density measuring diameter located second segment duodenum uncinate process pancreas esophagogastroduodenoscopy revealed remarkable findings remnant stomach however scope could reach duodenum due altered anatomy roux reconstruction distal gastrectomy patient underwent surgical resection mass lesion clinical diagnosis malt lymphoma relapse orange calculus apparent thinly extended duodenal wall stretching hall closed meticulous primary suture duodenal resection macroscopically extracted calculus solid quite hard measured cut surface revealed layered structure outer areas granulated contents center although duodenal diverticula relatively common enterolith developing within juxtapapillary duodenal diverticulum rare best knowledge first case due altered anatomy gastrectomy reported english literature
volcanic ash cloud detection difficult problem moderate resolution imaging spectroradiometer modis multispectral remote sensing application principal component analysis pca independent component analysis ica effective feature extraction methods based second order higher order statistical analysis support vector machine svm realize nonlinear classification low dimensional space based characteristics modis multispectral remote sensing image via presenting new volcanic ash cloud detection method named combined pca ica weighted svm cpiws current study tested real volcanic ash cloud detection cases sangeang api volcanic ash cloud may experiments suggest overall accuracy kappa coefficient proposed cpiws method reach respectively certain conditions suitable weighted values certain feasibility practical significance
assessing quality aperture synthesis maps relevant benchmarking image reconstruction algorithms scientific exploitation data optical long baseline interferometers design upgrade new existing interferometric imaging facilities although metrics proposed contexts systematic study conducted selection robust metric quality assessment article addresses question best metric assess quality reconstructed image starts considering several metrics selecting based general properties variety image reconstruction cases considered observational scenarios phase closure phase referencing large telescope interferometer vlti combination two three four six telescopes end end image reconstruction accomplished mira software several merit functions put test found convolution effective point spread function required proper image quality assessment effective angular resolution images superior naive expectation based maximum frequency sampled array due prior information used aperture synthesis algorithm nature objects considered norm robust considered metrics linear less sensitive image smoothing high regularization levels cases considered metric allows implementation automatic quality assessment reconstructed images performance similar human selection
soil carbon redistribution arable land associated impacts carbon sequestration mineralisation may play important role global carbon cycle insight process chain erosion transport deposition significantly grown recent years still major gaps understanding making difficult make overall assessment erosion processes carbon exchange soil atmosphere one issue potential effect soil degradation erosion processes may effluxes eroding sites major goal study therefore analyse understand effects interrill erosion soil crusting soil aggregate breakdown situ effluxes therefore set rainfall simulations carried bare loess burden soil different antecedent soil moisture content treatments compared controls protected rain drop impact using fine meshed geotextile expected runoff sediment delivery significantly larger bare compared covered soils surface runoff sediment delivery increased cases rising antecedent soil moisture well rainfall duration crust thickness increased antecedent soil moisture rainfall intensity general smaller controls however variations crust thickness result significant differences situ measured effluxes also destruction soil crust six seven days measurements significant effect leads conclusion crusting interrill erosion minor effect situ effluxes nevertheless recognised topsoil carbon preferentially removed due interrill erosion may result additional release depositional sites stream standing water bodies elsevier rights reserved
study presents effects various mineral admixtures silica fume fly ash ground granulated blast furnace slag ggbfs metakaolin steel fiber rheology strength chloride ion penetration resistance characteristics wet mix shotcrete wms mixtures made crushed aggregates mixtures tested study mostly ternary mixtures blended silica fume potential implications measured rheological properties relation pumping shooting performance wms mixtures also analyzed results shown silica fume may effective admixture benefiting pumpability shootability wms fly ash found adversely affect pumpability wms mixtures markedly increasing torque viscosity ggbfs non significant effects pumpability shootability whereas strongly improved chloride ion penetration resistance strength wms also identified metakaolin mass cement necessary enhance pumpability shootability chloride penetration resistance wms despite many expected advantages using steel fibers wms special attention paid prevent excessive degradation pumpability chloride ion penetration resistance high dosage steel fibers used elsevier ltd rights reserved
paper aims introduce summarize emphasize importance evidence based pharmacological treatment guideline depression korea revised edition guideline broadly covers aspects pharmacological treatment patients korea diagnosed moderate severe major depression according dsm guideline establishment process involved determining answering number key questions searching selecting publications evaluating recommendations preparing guideline drafts undergoing external expert reviews obtaining approval guideline adaptation process conducted revised edition guideline strongly recommends pharmacological treatment considered appropriate current clinical situation korea considered helpful selecting appropriate pharmacological treatment patients diagnosed major depressive disorder therefore wide distribution guideline recommended
background intensive care unit icu high cost high risk area analysis previous litigation cases may help improve future practice methods claims received national health service litigation authority nhsla relating icu analysed according clinical categories severity outcome classified none low moderate severe death cost claims corrected values using retail prices index results claims nhsla dataset excluded claims relate icu care included analysis commonest claim categories number claims positioning nursing standards skin care mostly relating pressure sores infection respiratory airway commonest claims relating patient death respiratory airway missed delayed diagnosis paediatrics claims categories highest proportion severe outcomes positioning nursing standards skin care infection total cost closed claims pound categories incurring highest costs infection pound million positioning skin care nursing standards pound million delayed inadequate treatment pound million conclusions litigation arising care icu common costly likely follow poor outcome whilst importance airway respiratory care infection control measures highlighted clear prominence pressure sores icu related litigation worrisome represents one particular area practice improvement
introduce architecture undertaking data processing across multiple layers distributed computing infrastructure composed edge devices making use internet things iot based protocols intermediate gateway nodes large scale data centres way data processing intended carried data centre pushed edges network enabling efficient use data centre network resources suggest need specialist data analysis management algorithms resource aware able split computation across different layers propose coordination mechanism able combine different types data processing capability transit situ application scenario used illustrate concepts subsequently evaluated multi site deployment
youth movements israel non formal organizations educate social political involvement provide broad platform youth involvement community study explored question social activism adolescents elect membership youth movements leadership role instructing younger members also reflect environmentalism survey young instructors drawn official youth movements findings environmental literacy variables show youth generally knowledgeable environmental problems express technical optimism leads limited concern environment show limited recognition importance environmental education show limited acknowledgment necessity changes personal consumerism findings also show environmental issues mind since conversation topic peers family nonetheless youth also demonstrate strong self efficacy effect change view role models younger members express willingness include environmentally supportive activities within regular youth movement activities valuing nature also provides foundation building environmental values analysis shows findings contribute theoretical practical tools incorporating sustainability within youth movement framework help realize potential promoting sustainability society
background peristomal dermatitis common complication patients united states ostomy role stoma skin care products peristomal dermatitis poorly understood objective evaluate stoma skin care products cause peristomal dermatitis methods aretrospective chart review patients peristomal dermatitis four academic hospitals january march performed patient demographics clinical information use test patch test results documented results eighteen patients identified peristomal dermatitis tested twelve peristomal contact dermatitis identified numerous stoma skin care products triggers irritant allergic contact dermatitis common stoma skin care product used involved dermatitis cavilon sting barrier film conclusions data support paradigm shift whereby healthcare workers treating patients peristomal dermatitis currently considered reaction mainly bodily fluids must consider products used protect skin potential triggers disease therefore patients peristomal dermatitis tested stoma skin care agents determine need removal change products additionally full ingredient labelling manufacturers would help identify new allergens irritants
paper modified discrete expansion method used construct exact solutions toda lattice equation ablowitz ladik lattice equations aid computer symbolic computation obtained uniform way hyperbolic function solutions trigonometric function solutions rational solutions two nonlinear lattice equations parameters taken special values known solutions recovered shown modified method symbolic computation provides effective mathematical tool solving nonlinear lattice equations science enginnering
catalysts oxygen evolution reaction oer play important role conversion solar energy fuel earth abundant water splitting electrolysis heterogeneous electrocatalysts hydrogen oxygen evolution reactions oer exhibit catalytic activity depends electronic properties oxidation states local surface structure spinel ferrites mfeo based materials attractive catalytic water oxidation due well known stability alkaline medium easy synthesis existence metal cations various oxidation states low cost tunable properties desired metal substitution understand better catalytic activity mfeo detail role studied mxni xfeo prepared sol gel method results showed bare nifeo better catalytic activity eta tafel slope dec compared containing mxni xfeo eta tafel slope dec alkaline medium substitution found suppress catalytic activity nifeo degradation catalytic activity increase content accounted detailed investigations
wireless sensor networks wsns large number nodes densely deployed open environment gather useful required information nodes small size operating limited processing capabilities scarce working memory battery life powerful radio transceivers communicate wireless media radio waves insecure nature therefore using waves communication always opportunities different attacks network wireless techniques founded cluster based sensor network forwarding cluster head chs data secure manner important chs collect data cluster members send sink node base station securing data propose mechanism termed icmds inter cluster multiple key distribution scheme wireless sensor networks enables securing entire network icmds use two phases security implementations sensor node authenticity communicating recovery phenomena also stated time ceases function due high energy consumption elsevier rights reserved
synchronous reluctance motor synrelm permanent magnet assisted synchronous reluctance motor assisted synrelm rated power level designed help finite element analysis fea performances levels compared shelf inverter fed variable speed squirrel cage induction motor scim surface mounted permanent magnet synchronous motor smpmsm respectively comparison resulting average torque operating speed range torque ripple investigated two prototypes fabricated experimental measurements carried validate simulation data identified synrelms especially assisted permanent magnets pms could compete induction motors even synchronous motors pmsms certain operating conditions
objective children adhd increased risk later developing personality disorders criminal behavior object present review analyze associations adhd antisocial personality disorder aspd method review literature done using embase psycinfo medline databases results eighteen prospective studies showed adhd without comorbid conduct disorder strong predictor risk later development antisocial personality disorder aspd cross sectional retrospective studies suggested adhd might separate subtype adhd especially impulsivity adhd predictor later development aspd callous unemotional traits adhd children called risk factor later aspd conclusion increased risk children adhd without comorbid develop later onset antisocial personality disorder
simulation study discusses application multimode combustion engine mild hybrid electric vehicle hev three way catalytic converter twc operation lean combustion mode homogeneous charge compression ignition hcci results oxidation oxygen storage capacity osc twc thereby twc ability convert nox lean conditions removed succeeding depletion osc rich spark ignition conditions required winch results significant fuel efficiency penalties case mild hev torque assist electric motor able extend residence time hcci thereby reducing number osc depletion events applied supervisory controller decides switch hcci based equivalent consumption minimization strategy ecms incorporates fuel penalties associated mode switching osc depletion shown impact osc depletion drive cycle fuel economy mild hev still significant much smaller case vehicle without electric motor prolonged operation lean hcci mode leads substantial amounts tailpipe nox drive cycles tested case study two modifications system hardware introduced counterintuitive results first hcci regime constrained conditions engine nox levels extremely low second size osc significantly reduced allowing much faster less inefficient depletion associated drive cycle results show substantial reduction tailpipe nox fuel economy benefits maintained ifac international federation automatic control hosting elsevier ltd rights reserved
purpose study examine potential effects reallocating time sleep sedentary active behaviours fatigue symptoms quality life sample non hodgkin lymphoma survivors non hodgkin lymphoma survivors identified western australian cancer registry response rate median age years wore actigrapha gtx accelerometer days completed fatigue scale functional assessment cancer therapy general pittsburgh sleep quality index used isotemporal substitution methods linear regression models examine potential effects reallocating time sleep sedentary activity behaviours fatigue quality life data collection conducted western australia significant differences observed fatigue symptoms min per day bouted moderate vigorous physical activity min reallocated min per day sleep points sedentary time bouts min points sedentary time non bouts points light intensity activity points isotemporal substitution effects reallocating sedentary time sleep light physical activity bouted physical activity significantly associated fatigue quality life findings present study may aid development delivery health behaviour interventions likely influence health outcome interest
paper presents new hybrid modeling technique efficient simulation guided wave generation propagation interaction damage complex composite structures local finite element model deployed capture piezoelectric effects actuation dynamics transmitter global domain wave propagation interaction structural complexity structure features damage solved utilizing local interaction simulation approach lisa hybrid approach allows accurate modeling local dynamics transducers keeping lisa formulation explicit format facilitates readiness parallel computing global lisa framework extended kelvin voigt viscoelasticity theory include anisotropic damping effects composite structures improvement existing lisa formulation global lisa framework implemented using compute unified device architecture running graphic processing units commercial preprocessor integrated seamlessly computational framework grid generation material property allocation handle complex structures excitability damping effects successfully captured hybrid model experimental validation using scanning laser doppler vibrometry demonstrate capability hybrid approach complex structures guided wave propagation interaction delamination composite panel stiffeners presented
work undertaken determine genesis role creativity formation mental qualities gave homo sapiens evolutionary advantages intra interspecific competition period intraspecific bifurcation hominids border middle upper paleolithic creativity allowed design adaptive forms purposeful behavior corresponding conditions degree uncertainty create stable mental constructs absence perceptual sources require reactive behavior visualization target image originally applied instructional value process semantic filling transformed symbol getting qualities perceptual source loses connection primary value initiates creation qualitatively new needs hominids bilateral direct inverse relations system subject symbol ability produce prognostic hypothesis expansion operating range mind allowed ability search change tactics adaptive behavior gave results improvements quality life increase life expectancy genetically fixed domination intra interspecific competition emergence new operating systems psyche including emergence development symbolic thought criterion creativity potential ability quantitative measurement propose value deviation creative oscillations proposal creative individual boundaries stereotypes cognition sphere deviation border recognizable unrecognizable social sphere acceptable unacceptable
general synthesis procedure given versatile signal flow graph realization general transfer function using current differencing buffered amplifier cdba proposed configuration uses cdbas capacitors resistors number resistors reduced special cases circuit eligible obtain variety transfer characteristics common denominator polynomial easily converted different modes operations straightforward find values passive elements coefficients transfer function realized simulations results obtained using commercially available active component cmos technology well make proposed circuit attractive elsevier gmbh rights reserved
whole process cost control project construction popular various reasons actual implementation become mere formality development information technology building information model entered practical stage domestic obtained good effect multiple projects get industry wide attention order promote whole process cost control introduce building information model project construction management analysis building information model different role various stages whole process cost control application different forms building information model difficulties whole process construction project cost control building information model application implementation reference value promotion whole process cost control
international concern alarming levels childhood obesity seen proliferation interventions filtering school physical education programmes designed influence children health practices attitudes article addresses one obesity prevention intervention global children challenge day pedometer monitored event aimed children involving parents teachers research problematises effects gcc pedometer exercise regime demonstrate pedometer measurement imperative made available gcc enables exercise measured potential health benefits also makes available tools inextricably linked antagonistic body relations could propel students self monitoring world dominated numbers illustrate emphasis measurement allows comparisons dividing practices self surveillance surveillance others formation particular kinds subjectivities study discursive construction student subjectivities gcc took place one strategically chosen australian primary school depth interviews conducted one teacher four year students parent child order produce rich contextual data foucauldian concepts power knowledge technologies self underpinned study gore methodologies analysing techniques power regimes truth used explore functioning power formation subjectivities gcc analysis suggests need move away constraining construct measurement primary physical education classroom promote self reflective mindful physical activity rather telling students move bodies
paradigm new european higher education area places together teaching learning guidelines models fact demands teacher adapt function considering new methods locate students centre process context definition academic curriculum future engineers field manufacturing engineering bilbao engineering faculty upv ehu presented must taken account metalworking industry primary importance region university must face challenge training engineers different levels industry years degree choose research career carry thesis intermediate training specialists machine tools industry activities long life learning also present faculty
promote energy utilization efficiency internal combustion engine approach electronically controlled turbocharger ect engine exhaust gas energy recovery investigated method test coupling numerical simulation first tests turbocharged gasoline engine high speed motor conducted provide experimental data numerical simulation simulation model ect engine built calibrated working processes ect engine simulated results show recovered exhaust gas energy ect increases decrease pass valve opening due rising exhaust gas mass flow rate pumping loss also ascends limited original engine turbocharger map engine working points beyond turbine map pass valve opening increases certain degree improve energy recovery potential ect larger turbine rematched working processes ect engine whole operating conditions resimulated results indicate engine exhaust gas energy recovered ect low load low speed area due low exhaust gas pressure effective working area load speed ascend recovery efficiency ect utilization efficiency exhaust gas energy increase maximum values reach respectively demonstrate ect effectively recover engine exhaust gas energy
parental criminal justice involvement prevalent united states potentially associated range negative outcomes children including child abuse neglect however association prior parental criminal justice involvement child maltreatment well understood paper reviewed existing literature regarding maltreatment victimization among children parents prior criminal justice involvement results ten reviewed studies demonstrated association prior parental criminal justice involvement child maltreatment provide sufficient evidence determine whether parental criminal justice involvement independent risk factor child maltreatment specific mechanisms association occurs recommendations future research include use multivariate analysis methods account variations type timing parental criminal justice involvement child maltreatment implications practice include development strategies address adverse family contexts commonly found among parents children elsevier ltd rights reserved
purposemedication error significant source morbidity mortality among patients clinical cost effectiveness evidence required implementation quality care interventions reduction error related cost key potential benefit interventions addressing medication error aim review describe quantify economic burden associated medication error methodspubmed cochrane embase cinahl econlit abi inform business source complete searched studies published assessing economic impact medication error included cost values expressed euro narrative synthesis performed resultsa total articles identified database searching included review one study met applicable quality criteria fifteen studies expressed economic impact monetary terms mean cost per error per study ranged euro euro healthcare costs used measure economic impact included studies one study measuring litigation costs four studies included costs incurred primary care remaining measuring hospital costs five studies looked general medication error general population studies reporting economic impact individual type medication error error within specific patient population conclusionsconsiderable variability existed studies terms financial cost patients settings errors included many poor quality assessment economic impact conducted predominantly hospital setting little assessment primary care impact limited parameters used establish economic impact copyright john wiley sons ltd
fat file system one common file systems various targets operating systems however performance issue sequential writing low bandwidth storage due reading fat area directory entries paper design implement efficient fat caching mechanism sequential writing low bandwidth mechanism consists two parts metadata cache whole fat read ahead cache result show improvement sequential writing low bandwidth storage caching mechanism
background data use surgical drains traditional splenectomy largely debated several authors unfavorable use advent laparoscopic splenectomy role discussed increased risk undetectable pancreatic gastric colon injury challenging laparoscopic removal spleen induced surgeons reconsider advantages related use methods one hundred seventeen consecutive cases laparoscopic splenectomy routine use surgical drains reviewed indications surgery length operations post operative day drain removal post operative complications retrospectively analyzed results laparoscopic splenectomy performed idiopathic thrombocytopenic purpura patients splenic lymphoma hereditary spherocytosis beta thalassemia diseases cases conversion open surgery necessary cases drains removed days surgery within days within months cases cases post operative bleeding detected drainage required operation one patient myelofibrosis massive splenomegaly developed late post operative subphrenic abscess successfully treated percutaneous drainage conclusions authors experience use drains laparoscopic splenectomy helped detect early post operative bleeding surgical drains could reduce incidence fluid infra abdominal collections infections use recommended laparoscopic approach especially technically demanding surgical procedures
current study investigated whether manipulations affective cognitive empathy differential effects observed behavior self reported outcomes adolescent mother conflict discussions examined situational empathy inductions interact preexisting empathic dispositions promote ecological validity conducted home visits study conflict discussions real disagreements adolescent mother relationships explored roles sex age maternal support power covariates moderators results indicated affective empathy manipulation significant effects behavior although trend hypothesized direction suggested affective empathy might promote active problem solving cognitive empathy manipulation led lower conflict escalation promoted oriented listening adolescents low dispositional cognitive empathy state trait interactions indicated empathy manipulations significant effects self reported outcomes adolescents lower dispositional empathic concern adolescents manipulations promoted outcome satisfaction cognitive manipulation promoted perceived fairness suggests cognitive empathy particular allows adolescents distance emotional heat conflict listen mothers point view leading outcomes perceived satisfying fair findings relevant interventions clinicians demonstrate unique effects promoting affective versus cognitive empathy even minimal manipulations promoted significant effects observed behavior self reported comes particularly low empathy adolescents stronger structural interventions likely marked benefits elsevier inc rights reserved
lower jaw frequently exposed fracture accidents violence accidental falls sports injuries pathological fracture etc investigated behaviour mandibular bone particular clinical case fracture experimentally applied two osteosynthesis plates analyzed effects occlusal loading fracture line finite element method observed case maximum deformations occur mandibular condyles maximum minimum normal stresses occur osteosynthesis plates even bite mastication determine important efforts osteosynthesis plates titanium alloy supports well loads important aspect bone parts healing object excessive mechanical loads
primary aim determine efficacy distress thermometer screening anxiety mood problems university washington quality life version uwqol secondary aims evaluate association demographic clinical health related qol variables significant distress two hundred sixty one disease free hnc ambulatory patients attending routine follow clinics prospectively recruited uwqol completed pre consultation receiver operating characteristic roc curve analyses score anxiety dysfunction yielded area curve auc sensitivity specificity cut corresponding auc mood sensitivity specificity treatment radiotherapy longer consultation time associated significant distress significant distress also reported two third reporting less good overall qol distress levels particularly associated poor social emotional function association seen poor physical function reasonable screening tool distress hnc population cut score effective identifying significant distress significant distress associated survivors poor health related quality life received radiotherapy patients longer consultation times clinic
introduction ghana currently developing provision dermatology services epidemiologic studies skin diseases seen ghanaian dermatologists needed guide efforts aimed describe skin conditions seen management practices ghanaian dermatologists specialized clinic methods conducted chart review new patients presenting korle teaching hospital dermatology clinic results among patients studied discrete diagnoses made commonly diagnosed skin conditions infections dermatitis atopic dermatitis acne vulgaris scabies common specific diagnoses among infants children adolescents common diagnosis atopic dermatitis respectively acne vulgaris common skin condition diagnosed young adults irritant contact dermatitis common among adults lichen planus commonly diagnosed skin condition senior population diagnoses made dermatologists differed referral diagnosis documented primary care providers patients frequently recommended treatments antihistamines topical steroids diagnostic biopsies performed conclusion study summarizes skin diseases seen management practices ghanaian dermatologists specialized clinic large public teaching hospital results study help guide future dermatology education development efforts ghana
investigate relationship overactive bladder oab metabolic syndrome mts using neck circumference retrospective view prospective collected data women without oab enrolled study august december patients administered oab validated questionnaires oab whose score accepted oab patients divided two groups group consisted patients oab group consisted patients without oab demographic data anthropometric measurements blood analyses recorded statistical analyses including receiver operating characteristic roc curves performed statistically significant mean age years patients group patients group oab scores significant higher group group waist circumference measurements statistical significant longer group group multivariate logistic regression analyses age body mass index mts statistical significant associated oab roc curves area curve auc relationship oab auc relationship oab cut values oab determined respectively oab metabolic syndrome seems like common women without may novel indicator oab selected female patients mts
review recent studies early childhood altruism followed report study development altruism early childhood ages years terms children ability willingness help share donate preschool children videotaped interacting pairs matched age sex age appropriate structured altruism task opportunities help share arose natural flow events results indicate even youngest children age displayed altruistic acts number children showing altruism number altruistic acts greater succeeding age level sharing common altruistic behavior frequent helping donation behaviors earlier ages possible explanations different developmental trajectories different altruistic acts discussed emphasis differing cognitive empathic demands situation main contributions study include demonstration different developmental trajectories different types altruistic acts age related increase spontaneous altruistic acts toward peers years age utility naturalistic structured observational task study spontaneous altruism towards peers young children
interstitial lung disease ild group disorders often characterized fibrosis lung parenchyma typically causing increased dyspnea functional limitation early mortality approximately ild patients provided confident diagnosis despite exhaustive search potential etiologies multidisciplinary review occur due incomplete acquisition diagnostic studies conflicting overlapping features non classifiable histological findings clinical features unclassifiable ild described several recent studies showing population includes heterogeneous collection patients similar characteristics compared mixed ild cohorts pharmacotherapy patients unclassifiable ild typically guided multidisciplinary review considers likely diagnosis anticipated disease behaviour objective review summarize recent studies related unclassifiable ild focus prevalence characteristics outcomes limitations literature identified including inconsistent terminology lack precise definition unclassifiable ild
objective early biomarkers alzheimer disease needed developing therapeutic interventions measures attentional control stroop type tasks discriminate healthy aging early stage predict future development cognitively normal individuals disruption resting state functional connectivity mri fcmri reported healthy controls risk explored relationship among stroop performance fcmri csf beta levels cognitively normal older adults method computerized stroop task along standard neuropsychological measures fcmri csf obtained cognitively normal older adults compared relationship stoop performance including measures reaction distributional analyses composite scores four resting state networks rsns default mode dmn salience sal dorsal attention dan sensory motor smn modulatory influence csf beta levels results larger stroop effect errors associated reduced fcmri within dmn sal reaction time distributional analyses indicated slow tail distribution related reduced fcmri functional connectivity within sal standard psychometric measures related rsn composite scores relationship stroop performance dmn sal functional connectivity stronger csf beta positive individuals conclusions link exists rsn composite scores specific attentional performance measures measures may sensitive biomarkers
objectives children differ adults expression dizziness symptoms causes dizziness several studies benign paroxysmal vertigo childhood bpvc vestibular migraine seen exclusively children vertigo age threshold used define children varies reported studies adolescents dizziness study investigated prevalence vestibular balance disorders according age category multi center study otolaryngology departments hospitals children adolescents methods children adolescents aged visited otolaryngology departments hospitals dizziness included classified patients three categories preschool including year olds school age year olds adolescents year olds patients reviewed retrospectively based clinical charts results preschool age group bpvc common followed school age group bpvc vms common followed psychogenic vertigo benign paroxysmal positional vertigo bppv adolescents common meniere disease cardiogenic vertigo bpvc seen primarily adults also seen adolescents conclusion children adolescents dizziness bpvc common diseases prevalence disease age showed differing distributions findings help diagnosing managing children adolescents vertigo elsevier rights reserved
tracking nonstationary narrowband signals often accomplished using algorithms called adaptive notch filters anfs generalized adaptive notch smoothers ganss extend concepts adaptive notch filtering two directions firstly designed estimate coefficients nonstationary quasi periodic systems rather signals secondly employ noncausal processing greatly improves accuracy applied whenever additional delay tolerated paper develops novel performance assessment mechanism gans allows one evaluate tracking accuracy smoother without prior knowledge true values system frequency coefficients extension employed build parallel bank filters automatically chooses one best matched unknown possibly time varying tracking conditions elsevier rights reserved
modern smart environments equipped multitude devices sensors aimed intelligent services presence diverse devices raised major problem managing complex environments rising solution problem modeling user goals intentions interacting respective smart environments using user defined goals generally solution advocates user goal represented combining devices smart appliances sensor actuators particular states domotic effects high level modeling approach provides ambient intelligence ami designers integrators high level abstract layer enables definition user goals smart environment declarative way used design develop intelligent applications paper describes approach automatic evaluation domotic effects combined boolean expressions provide efficient intelligent monitoring domotic structure environment effects evaluation addresses problem finding new values domotic effects defined environment one devices change state one sensor value recorded environment hence determining new overall state environment paper also presents architecture implement evaluation domotic effects results obtained carried experiments prove feasibility approach highlight responsiveness implemented effect evaluation
resistance boxes used calibration devices measure resistance many electrical laboratories research new automated resistance box presented mainly consists three decades design four different internal resistive elements decade generates different output resistance values therefore economical practical compared usual decades produce values using internal resistive elements per decade resistance values obtained possible combinations new decades design fabrication process characterization new demonstrated detail including main specifications advantages maximum relative deviation nominal values new steps ppm elsevier ltd rights reserved
obesity associated mood disorders depression anxiety aim study investigate whether treadmill exercise benefits mood disorder high fat diet hfd induced obesity mice randomly divided four groups control control exercise high fat diet hfd hfd exercise obesity induced week hfd exercise groups exercise performed times week weeks exercise duration intensity gradually increasing week intervals mice tested tail suspension elevated plus maze tasks order verify mood disorder like behavior depression anxiety obesity present study number tphpositive cells expression htsa hit protein decreased dorsal raphe depression anxiety like behavior increased hfd group compared con group contrast treadmill exercise ameliorated mood disorder like behavior hfd induced obesity enhanced expression serotonergic system dorsal raphe concluded exercise increases capacity serotonergic system dorsal raphe improves mood disorders associated hfd induced obesity
improving project performance always emphasized construction projects project objectives contradict project manager must apply mitigating conflict resolution strategies remove minimize level contradiction order enhance project performance typical example conflict cost schedule cost tends increase schedule crashed sped although current project control systems attempt diagnose root cause performance deviations suggest corrective action none designed resolve conflicts systematic innovative manner improve project performance purpose paper present systematic structured approach guide project managers propose corrective action plans lead minimal conflict ultimately better project performance resolving contradictions generate effective corrective action plans would enhance project performance conflicts among competing project performance indices cost schedule safety quality obvious project innovative approach uses theory inventive problem solving triz develop framework conflict resolution strategy called techniques resolving project performance contradictions trac techniques resolving performance contradictions trac provides algorithmic approach solving performance contradictions order optimize overall project performance trac user oriented methodology presents new model performance problem solving assist project managers corrective action exercise trac methodology demonstrated two case studies indicate workability model usefulness resolving performance contradictions contraction projects
image based visual discomfort analysis strong potential detect glare order predict occupant satisfaction space however order design buildings occupant visual comfort mind architects need ability predict glare renderings rather photographs paper compare glare measurements high dynamic range photographs computer renderings daylit space clear cloudy sky conditions order assess accurately architects predict glare though simulation use two ray tracing engines radiance accelerad scenes illuminated mathematically defined sky model recorded outdoor luminance levels photographs depending scene methods predict daylight glare probability levels due bright sources accuracy discomfort glare due contrast accuracy glare predictions sensitive modeling measurement accuracy simulation parameters accurate results come relatively fast simulations furthermore graphics acceleration able produce accurate glare predictions within minutes using accelerad achieving speedup radiance times elsevier ltd rights reserved
evidence imitated social effects imitation child actions may used strategy promote social engagement children autism spectrum disorder asd observation someone imitates recruits indeed neural areas involved social cognition reviewed studies exploring behavioral consequences imitated children asd aimed assessing social skills targeted strategy factors may improve response imitated strategy improves social gazes proximal social behaviors play skills particularly children low developmental level also strategy implemented children mothers imitated may used tool early intervention improve social skills helping assess effects intervention behavioral neural level
background substantial evidence humans animals prolonged reduction plasma thyroid hormone concentration leads reproductive problems including disturbed folliculogenesis impaired ovulation fertilization rates miscarriage pregnancy complications objective present study examine consequences chronic hypothyroidism induced adulthood size ovarian follicle pool order investigate adult female rats provided either control iodide deficient diet combination perchlorate supplementation inhibit iodide uptake thyroid sixteen weeks later animals sacrificed blood collected hormone analyses ovaries evaluated histologically results time sacrifice plasma thyroid stimulating hormone concentrations fold increased thyroxine concentrations negligible tri iothyronin concentrations decreased hypothyroid group confirming animals hypothyroid primordial primary preantral follicle numbers significantly lower hypothyroid ovaries compared euthyroid controls downward trend antral follicle corpora lutea numbers observed surprisingly percentage atretic follicles significantly different two groups suggesting reduced preantral antral follicle numbers presumably consequence increased degeneration follicle types hypothyroid group plasma anti mullerian hormone amh levels showed significant correlation growing follicle population represented total ovarian number primary preantral antral follicles suggesting also hypothyroid conditions amh serve surrogate marker assess growing ovarian follicle population conclusions induction chronic hypothyroid condition adult female rats negatively affects ovarian follicular reserve size growing follicle population may impact fertility
stated roughly electrical incidents involve workers whose primary function electrical nature also encouraged address electrical safety workers workers whose job responsibilities involve working near energized electrical circuits paper program includes specific briefings non electrical workers well workers may need perform normal activities proximity energized electrical conductors presented program uses targeted approach specific areas welding excavating rigging chart reading switching cord plug equipment several general areas point hazards may exist avoid site experience years supports assertion half electrical incidents involve non electrical workers prompted develop specific briefings enhance knowledge non electrical worker regarding safe electrical practices promotion may electrical safety month development informative presentations delivered general site population well electrical workers greatly improved hazards awareness status general worker site
purpose paper addresses evolution fuzzy systems core applications automotive engineering methods presented study based analysis bibliography dedicated fuzzy sets fuzzy control ground vehicles special attention given fuzzy approaches used following domains automotive engineering vehicle dynamics control systems driver driving environment identification ride comfort control energy management electric vehicles results bibliographical analysis supplemented statistics relevant research publications allowed allocate important fuzzy application cases domain particular concerns driver identification human machine interface recognition road conditions controllers vehicle chassis powertrain systems found fuzzy methods primary use tasks requiring identification forecasting procedures especially conditions limited informational space additional observation also derived presented survey points reasonable integration fuzzy technique control engineering methods improve performance automotive control systems conclusions aggregate performed review indicates fuzzy computing considered versatile tool automotive engineering applications different nature
paper novel tensor based image segmentation algorithm tbisa presented dedicated segmentation colour images purpose tbisa distinguish specific objects based characteristics shape colour texture mixture features information available colour channel data nonetheless performing image analysis pixel level using rgb values allow access information texture hidden relation neighbouring pixels therefore take full advantage available information propose incorporate structural tensors feature extraction method forms enriched feature set apart colour intensity conveys also information texture set next processed different classification algorithms image segmentation quality tbisa evaluated series experiments carried benchmark images obtained results prove proposed method allows accurate fast image segmentation
background highly effective hepatitis virus hcv therapies spurred scale treatment populations greater risk reinfection sustained virologic response svr reinfection may higher hiv hcv coinfection prior studies considered small selected populations assessed risk factors reinfection svr representative cohort canadian coinfected patients clinical care methods patients achieving svr hcv treatment followed hcv rna measurements every months prospective cohort study used bayesian cox regression estimate reinfection rates according patient reported injection drug use idu sexual activity among men sex men msm results patients treated hcv achieved svr least subsequent rna measurement person years follow pyfu svr became hcv rna positive adjusted reinfection rate per pyfu first year svr highest reported high frequency idu credible interval cri followed msm reporting high risk sexual activity cri low frequency idu cri rate low risk msm cri similar reference patients cri reinfection rates diminish time conclusions hcv reinfection rates varied according risk measures needed reduce risk behaviors increase monitoring high risk idu msm hcv elimination targets realized
hiv infected individuals increased risk osteoporosis despite effective viral suppression observations myostatin null mice increased bone mass led hypothesize simian immunodeficiency virus siv associated bone loss may attenuated blocking myostatin tgf beta signaling proof concept study pair housed juvenile male rhesus macaques inoculated sivmac four weeks later animals treated vehicle conjugated soluble activin receptor iib actrb week antagonist myostatin related members tgf beta superfamily limb trunk bone mineral content bmc density bmd using dual energy ray absorptiometry circulating markers bone growth turnover serum testosterone levels measured baseline week intervention period increase bmc significantly greater actriib treated group placebo group bmd also increased significantly actriib treated macaques placebo treated animals serum osteocalcin two fold higher actriib treated group placebo group serum terminal telopeptide testosterone levels differ significantly groups expression levels tnfalpha gadd sclerostin bone marrow significantly lower actriib treated group placebo group conclusion administration actriib siv infected juvenile macaques significantly increases bmc bmd association reduced expression levels markers bone marrow inflammation published elsevier inc
vinilcyclohexene diepoxide vcd causes premature ovarian failure may result estrogen deficiency characterizing transition estropause rodents equivalent menopause women estropause menopause associated metabolic derangements glucose intolerance insulin resistance glucocorticoids gcs known exert diabetogenic effects thus aimed investigate whether rats premature ovarian failure prone diabetogenic effects immature female rats received daily injections vcd body weight intraperitoneally consecutive days whereas control rats received vehicle days completion vcd administration rats divided groups ctl received daily injections saline days dex received daily injections dexamethasone days vcd treated ctl group vcd dex treated dex group experiments euthanasia occurred one day last dexamethasone injection vcd treated rats exhibited ovary hypotrophy reduced number preantral follicles premature ovarian failure impact body weight gain food intake reduced effects dexamethasone increase blood glucose plasma insulin triacylglycerol levels well reduction insulin sensitivity caused dexamethasone treatment exacerbated vcd dex group rats premature ovarian failure change neither hepatic content glycogen triacylglycerol glycerol release perigonadal adipose tissue glucose intolerance observed vcd group ipgit oral glucose challenge glucose intolerance compensatory pancreatic beta cell mass caused modified ovarian failure vcd dex group conclude reduced ovarian function major implications diabetogenic effects promoted treatment indicating factors related aging may make rats vulnerable side effects glucose metabolism elsevier ltd rights reserved
parental hip fracture associated increased risk offspring major osteoporotic fractures mofs comprising hip forearm clinical spine humerus fracture whether sites parental fracture used fracture risk assessment uncertain current study tested association objectively verified parental non hip mof offspring incident mof using population based administrative healthcare data province manitoba canada identified offspring linkage least one parent mothers fathers parental non hip mof offspring mof ascertained validated case definitions time dependent multivariable cox proportional hazards regression models used estimate adjusted hazard ratios hrs confidence intervals cis median years offspring follow identified incident mof among offspring offspring without parental non hip mof risks associated parental adjusted non hip mof adjusted strength association parental non hip mof offspring mof decreased older parental age non hip mof trend summary parental non hip mof confers increased risk offspring mof strength relationship decreases older parental age fracture american society bone mineral research
handwashing considered effective way reducing cross infection rates healthcare associated infection incidence meticillin resistant staphylococcus aureus higher many european countries government responded introducing cleanyourhandscampaign throughout england wales based success approach employed geneva alcohol hand rub placed every bedside acute hospitals ward housekeepers replenish supplies feedback compliance provided health workers posters promotional materials used remind health workers visitors use hand rub patients encouraged ask health workers cleaned hands contact paper argue evidence base underpinning cleanyourhandscampaign incomplete alcohol hand rub acknowledged useful adjunct hand hygiene effective circumstances evidence support use feedback performance encourage compliance evidence promotional materials posters patient reminders effective ethics encouraging hospital patients take responsibility safety questioned much success geneva must attributed attention given contextual factors within organization encouraged hand rub use especially hospital wide ownership initiative managers senior health professionals customized intervention another country fails consider local organizational factors likely influence implementation campaign unlikely effective concluded although hand hygiene undoubted importance undue emphasis placed quick fix solve unacceptably high rates healthcare associated infection national health service hospitals hospital infection society published elsevier ltd rights reserved
background objectiveobstructive sleep apnoea osa associated increased prevalence metabolic syndrome study explores effects continuous positive airway pressure cpap patients osa visceral mesenteric fat thickness carotid intima media thickness imt adipokines methodsa randomized controlled study conducted teaching hospital patients newly diagnosed osa receive either therapeutic cpap subtherapeutic cpap months visceral fat thickness carotid imt measured mode ultrasound adipokine levels assessed baseline months resultsaltogether patients received therapeutic cpap received subtherapeutic cpap without significant differences age versus years bmi versus epworth sleepiness scale ess versus apnoea hypopnoea index ahi versus minimum sao versus existing morbidities cpap usage therapeutic versus subtherapeutic night months adiponectin irisin levels changed significantly following therapeutic cpap months versus subtherapeutic cpap respectively serum level monocyte chemotactic protein mcp baseline positively correlated ahi significant changes observed adipokines visceral fat thickness imt conclusionshort term therapeutic cpap versus subtherapeutic cpap significantly reduce visceral fat thickness imt although reduces adiponectin increases irisin obstructive sleep apnoea associated increased prevalence metabolic syndrome randomized subtherapeutic continuous positive airway pressure cpap controlled study found significant improvement visceral fat carotid intima media thickness months cpap therapy
epidemiological studies demonstrated prevalence hypogonadism old males increases every additional decade life males present various symptoms including decrease sexual function decrease cognitive function altered lipid profile increased visceral adiposity changes bone density muscular strength secondary atrophy currently testosterone injections gel preparations used testosterone replacement therapy provides significant symptomatic improvements men late start hypogonadism long term benefits risks testosterone replacement therapy evident testosterone effects studied health related parameters prolonged period time large ongoing multicentric randomized clinical trial sponsored nih testosterone control old men low testosterone levels results may give answers possible benefits risks testosterone replacement aging males aging male diagnosed late start hypogonadism urologist discuss patient potential benefits risks testosterone therapy aging males significant erythrocytosis untreated sleep apnea prostate cancer high risk cardiovascular events must excluded testosterone replacement therapy currently enough evidences clearly state benefits testosterone replacement therapy aging males better risks treatment general recommendation given testosterone replacement therapy may applied aging males low testosterone levels independently significant signs symptoms
artificial neural networks ann capacities training classification decision give solution bearing diagnosis problem automatic classification vibratory signals corresponding various states machines intended increase precision accuracy reduce errors caused subjective human judgments however important note anns aids diagnosis must set optimum performance non existence predefined rules anns parameters setting number hidden neurons hidden layers etc obstruct achievement optimal performances use genetic algorithm solve problem parameters structure optimization ann paper discusses use ann multilayer perceptron mlp diagnosis electric motor bearings automatic classification various operating conditions machine signals taken experimental test rig processed using various methods signal processing calculated indicators used build patterns vector used following train test network used search optimize structure various parameters network simplifies neural network structure makes training process efficient giving best performances network
design optimization data centers achip dcoc requires accurate mathematical modeling workloads describe statistical physics inspired formalism allows derivation state space representation network dynamic optimization
main purpose paper design self tuning control algorithm adaptive cruise control acc system adapt behaviour variations vehicle dynamics uncertain road grade aim short time linear quadratic form stlqf estimation technique developed track simultaneously trend time varying parameters vehicle longitudinal dynamics small delay parameters vehicle mass road grade aerodynamic drag area coefficient next values estimated parameters used tune throttle brake control inputs regulate throttle brake switching logic governs throttle brake switching performance designed stlqf based self tuning control stlqf stc algorithm acc system compared conventional method based fixed control structure regarding speed distance tracking control modes simulation results show proposed control algorithm improves performance throttle brake controllers providing comfort travelling enhancing driving safety giving satisfactory performance presence different payloads road grade variations
colorblindness multiculturalism offer divergent prescriptions reducing racial tensions colorblindness encourages looking beyond racial differences whereas multiculturalism encourages recognizing introduce new construct perceived intentionality racial discrimination pird individuals beliefs intentional discrimination help explain colorblindness versus multiculturalism preferred potentially effective improving race relations first establish distinctiveness pird construct assess stability time across intergroup contexts studies observe greater pird predicts beliefs colorblindness versus multiculturalism improve race relations studies part unintentional versus intentional discrimination perceived stem ignorance misunderstanding versus knowingly treating racial groups unequally studies evidence also suggests pird may shape actual merits colorblindness multiculturalism improving race relationsvia encouraging donations study positive interracial interaction intentions study comfort discussing race following widely publicized shooting black teen study taken together empirical findings demonstrate usefulness pird understanding predicting influencing individuals preferences colorblindness versus multiculturalism elsevier inc rights reserved
contemporary powerful mathematical software enables new approach handling manipulating complex mathematical expressions mathematical objects particularly use symbolic computation leads new contribution constructing analyzing numerical algorithms solving difficult problems applied mathematics scientific disciplines paper concerned problem determining multiple zeros multiplicity known advance task seldom considered literature use computer algebra system mathematica employ symbolic computation several programs construct investigate algorithms determine sought zero multiplicity applying recurrent formula generating iterative methods higher order solving nonlinear equations construct iterative methods serve approximating multiple zero given function order multiplicity unknown simultaneously finding exact order multiplicity particular state useful cubically convergent iterative sequences find exact multiplicity iteration steps approach combined rapidly convergent method multiple zeros provides construction efficient composite algorithms finding multiple zeros high accuracy properties proposed algorithms illustrated several numerical examples basins attraction elsevier rights reserved
accumulating evidences showed thyroid hormone participated functioning reproductive system elevated level thyroid hormones negative impact reproductive system however molecular basis observation still remains fully understood show thyroxine significantly impaired human sperm motility molecular basis showed thyroxine receptor stimulation triggers phosphatidyl inositol kinase pik akt signaling activation leading ligase mdm phosphorylation serine directly interacted degradation degradation caused dependent dna damage checkpoint repair dysfunction eventually results dna damage accumulation sperm results highlight inhibition pik akt pathway degradation important maintaining sperm motility thyroxine receptor dependent manner elsevier rights reserved
stress glucocorticoids suppress adult neurogenesis hippocampus however molecular mechanisms underlying stress induced impairment adult neurogenesis poorly understood previously suggested cyclooxygenase cox common mediator stresses brain using lipopolysaccharide lps induced acute infectious stress model evaluated roles cox major downstream product prostaglandin pge adult neurogenesis influence glucocorticoids cox related signaling treatment rats lps significantly decreased neurogenesis dentate gyrus hippocampus inhibitory effect lps neurogenesis reversed glucocorticoid receptor antagonist moreover significantly enhanced increase messenger rna mrna levels cox microsomal prostaglandin synthase mpges hippocampus following lps stimulation administration selective antagonist pge receptor well cox selective inhibitor exacerbated suppression proliferation neural progenitor cells npcs gene expression receptors also increased following lps stimulation immunohistochemical studies indicated npcs expressed receptor whereas majority cells expressing cox mpges mature neurons results suggest acute infectious stress upregulates cox related signaling neurons plays protective role neurogenesis receptor least partially addition lps induced glucocorticoids suppress cox related signaling resulting decreased neurogenesis
hemorrhagic cystitis often develops patients treated cyclophosphamide cyp studies indicated rho kinase rock inhibitors may suppress detrusor overactivity symptoms possess anti inflammatory properties aim present study investigate whether inhibition rock reduces cystometric histopathological changes associated cyp induced cystitis rats received gsk rock inhibitor dose daily vehicle days acute chemical cystitis leading bladder overactivity induced cyp injection following cyp injection cystometric studies physiological saline performed moreover bladder edema evans blue dye leakage technique urothelium thickness measured cyp injection resulted significant increase cystometric parameters basal pressure threshold pressure bladder contraction duration relaxation time detrusor overactivity index non voiding contractions amplitude non voiding contractions frequency well increased evans blue extravasation bladder tissue whereas micturition voiding pressure voided volume post void residual volume threshold intercontraction interval bladder compliance volume threshold elicit non voiding contractions well urothelium thickness significantly decreased cyp injected rats administration gsk normalized abovementioned cyp injection induced changes inhibition rock found ameliorate cyp induced detrusor overactivity bladder inflammation data indicate uroprotective effects following rock inhibition suggests strategy may become interesting pharmacological tool prevent urinary adverse effects patients treated chemotherapy using cyp
several recent studies indicated mir plays critical roles various biological processes diseases however mechanism mir participation idiopathic pulmonary fibrosis ipf regulation ambiguous previous study demonstrated mir may function novel therapeutic target lung fibrosis blocking mitochondrial fission dependent dynamin related protein drp however regulatory mechanism mir drp yet investigated additionally whether mir act potential therapeutic verified vivo study mir expression ipf patients evaluated computational analysis dual luciferase reporter assay system used identify target gene mir cell transfection utilized confirm relationship ten eleven translocation tet validated direct target mir mir mimic inhibitor transfection significantly reduced increased tet protein expression respectively experimentation verified tet sirna interference could inhibit drp promoter hydroxymethylation finally mir agomir designed applied identify validate therapeutic effect mir vivo study demonstrated mir could inhibit tet expression base pairing complementary sites untranslated region regulate drp promoter hydroxymethylation furthermore mir could act potential therapeutic target ipf
several dna representations used study radio induced complex dna damages depending approach required level granularity among approaches mechanistic one requires resolved dna models atomistic dna descriptions complexity dna models make hard modify adapt order take account different biological conditions dnafabric project started provide tool generate visualise modify complex dna models current version dnafabric models exported geant code used targets monte carlo simulation work project used generate two dna fibre models corresponding two dna compaction levels representing hetero euchromatin fibres imported geant application computations performed estimate influence dna compaction amount calculated dna damage relative difference dna damage computed two fibres number projectiles found constant equal considered primary particles protons kev mev however tracks hitting dna target taken account relative difference important low energies decreases reach zero around mev computations performed models contain dna nucleotide pairs nevertheless dnafabric extended manipulate multi scale models molecular cellular levels program summary program title dnafabric catalogue identifier aezv program summary url http cpc qub summaries aezv html program obtainable cpc program library queen university belfast ireland licensing provisions apache license lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language computer computer gpu opengl compatible drivers operating system linux ubuntu ram gigabytes classification external routines opengl nature problem simulations implying dna geometrical models often show limitations support huge number dna constituents order allow users build visualise perform calculations detailed dna models including hundreds thousands dna elements dedicated framework needed solution method dnafabric library framework allows users easily build dna models display perform calculations dnafabric includes hierarchically organised dna models binary executable example named fibre dedicated render engine optimised opengl interface multi threading facilities unusual features dnafabric uses technologies computer graphics world allowing rendering huge dna models real time additional comments three examples provided examples folder basic example describes set simple dnafabric user application fibre example shows two dna fibre models used calculations paper movingspheres example demonstrates implement simulation interacting dna geometrical model running time user application started auto generated window show model efficiency rendering depends highly user hardware however user customise rendered elements contained application adjust required computer power elsevier rights reserved
interpersonal mindfulness parenting scale self report questionnaire measuring mindful parenting goal study explore psychometric properties factor structure portuguese version three studies conducted first study included mothers children adolescents second study included mothers children adolescents third study included mothers fathers children adolescents study exploratory factor analysis reliability analyses resulted five factor structure furthermore scale scores showed adequate internal consistency correlated expected measures self compassion parenting stress perceived stress evidencing adequate convergent validity study five factor structure confirmed confirmatory factor analysis study construct validity scale convergent known groups explored significant correlations found measures self compassion parenting styles anxious depressive symptomatology mothers reported higher levels compassion child emotional awareness child lower levels non judgmental acceptance parental functioning fathers study demonstrated mindful parenting measured assessment five dimensions listening full attention compassion child non judgmental acceptance parental functioning self regulation parenting emotional awareness child confirmed portuguese version adequate measure construct
aim work development characterization nisin loaded nanoparticles evaluation potential antifungal activity candidiasis fungal infection caused candida considered one major public health problem currently discovery antifungal agents present reduced null resistance candida development efficient drug release mechanisms necessary improvement candidiasis treatment nisin bacteriocin commercially available years exhibits antibacterial action food products potential antifungal activity among several alternatives used modulate antifungal activity bacteriocins polymeric nanoparticles received great attention due effective drug release control reduction therapeutic dose besides minimization adverse effects preferential accumulation specific tissues nisin nanoparticles prepared double emulsification solvent evaporation methods nanoparticles characterized dynamic light scattering zeta potential fourier transform infrared ray diffraction differential scanning calorimetry scanning electron microscopy antifungal activity accessed pour plate method cell counting using candida albicans strains vitro release profile vitro permeation studies performed using dialysis bag method pig vaginal mucosa franz diffusion cell respectively results revealed nisin nanoparticles spherical shape high loading efficiency vitro test results suggest promising application nanosystems prophylactic agent recurrent vulvovaginal candidiasis gynecological diseases
digitally controlled permanent magnet synchronous motors pmsms exhibit bandwidth limitations imposed delay high power applications rail transit negative impact delay particularly serious due low switching frequency inverter paper causes effects time delay analyzed sampling delay greatly reduced using multiple sampling method test results given verify effectiveness reliability proposed method
introduction prevalence morbidity eating disorders high patients bipolar disorder simple tools necessary easily rapidly screen bipolar patients objective aim study validate french version bipolar eating disorder scale beds method diagnoses established structured interview patients according dsm criteria beds translated french using appropriate methods patients administered following scales beds scoff bulimic investigatory test edinburgh bite eating disorder inventory two edi results beds score significantly higher bipolar patients beds showed high feasibility omission response excellent discriminating abilities roc auc sensibility specificity beds high internal consistency cronbach alpha coefficient test retest reliability icc floor ceiling effect observed beds sensitivity equivalent bite edi subscale beds specificity slightly lower edi subscale equivalent bite conclusion beds valid scale fast screening patients bipolar disorder easier administer currently used scales elsevier masson sas rights reserved
present method expands previous work learning human perceived style similarity across objects different structures functionalities unlike previous approaches tackle problem help hand crafted geometric descriptors make use recent advances metric learning neural networks deep metric learning allows train similarity metric shape collection directly since low high level features needed discriminate different styles identified neural network automatically furthermore avoid issue finding comparing sub elements shapes represent shapes rendered images show image tuples selected generated used efficiently deep metric learning also tackle problem training neural networks relatively small datasets show achieve style classification accuracy competitive state art finally reduce annotation effort propose method incorporate heterogeneous data sources adding annotated photos found online order expand supplant parts training data
paper reports experimental results regarding solubility argon nitrogen aqueous solutions tetradecyltrimethylammonium bromide ttab temperatures partial pressure gas mol ttab concentration measurements taken specially developed equipment following change gas pressure gas solubility determined applying henry law experimental results show solubility argon nitrogen ttab micelles times higher solubility pure water solubility studied gases larger ttab micelles dtab determined previous work experimental conditions showing effect addition methylene group alkyl chain dtab comparing results obtained observed ttab micelles larger higher solubilization capacity
recent studies emphasized influence resettlement factors mental health refugees resettling developed countries however little research addressed gender differences nature influence resettlement stressors sources resilience address gap knowledge investigating gender moderates mediates influence several sources distress resilience among afghan refugees residing northern california usa gender moderated effects four factors levels distress intimate extended family ties little correlation men distress levels strongly associated lower distress women english ability positively associated lower distress women men terms gender ideology traditionally oriented women egalitarian men lower levels distress experiencing greater dissonant acculturation increases distress men women influence gender interaction terms substantial patterns may reflect difficulty adapting different gender order future studies similar populations investigate gender differences sources distress resilience efforts assist new arrivals might inform changes gender roles may experience facilitate opportunities renegotiate gender roles
generally accepted hearing homophobic language detrimental well sex attracted young people writing survey australian sex attracted young people found almost half respondents reported hearing language regular basis considered offensive less known however heterosexual young people experiences homophobic language use often assumed motivated prejudice topic well studied using interviews online discussion young people aged years study explored heterosexual young people perspectives homophobic language use school contrary framing often used anti homophobia education meaning form language seen largely depend context employed frequently functioning reinforce masculine gender norms particularly popular male students furthermore many heterosexual participants study used homophobic language regularly see homophobic viewed school policies use homophobic language largely ineffective findings suggest heterosexual young people may respond favourably anti homophobia education programmes acknowledge variety meanings functions language commonly understood homophobic character
systematic data quality validation normalization strategy important component omic profile meta analysis ensuring comparability profiles exclusion experimental biases derived biological conclusions study present normalization methodology applied sets cerebellum gas chromatography mass spectrometry metabolic profiles days old male female animals adult onset hypothyroidism aoh mouse model combining sex comparative analysis employed aoh model concerns monitoring brain physiology balb mice eight week administration kclo drinking water initiated day life originating animal study tissues two sexes processed profiles acquired analyzed different time periods hence previously published profile set male mice first annotated based presently available resources validated acquired analytical conditions profiles sets corrected derivatization biases filtered low confidence measurements based criteria final normalized metabolite profiles contribute currently available omic datasets aoh effect brain molecular physiology especially respect sex differentiation multivariate statistical analysis indicated one unknown three succinate benzoate myristate metabolites significantly higher lower respectively cerebellum concentration hypothyroid compared euthyroid female mice respective numbers males two comparison euthyroid cerebellum metabolic profiles two sexes indicated metabolites including glucose myo scyllo inositol significantly lower concentration females versus males implies female mouse cerebellum conditioned smaller changes metabolic activity respect pathways involving metabolites compared male animals conclusion study indicated much subtler aoh effect cerebellum metabolic activity female compared male mice leaner metabolic profile female mouse cerebellum suggested potential factor contributing phenomenon elsevier rights reserved
although place related identity receiving increasing attention within environmental psychology field little attention paid deepen place identity local level better understand social nature urban identity focusing case zaragoza fifth largest city spain work aims contribute previous literature understanding shared city meanings sociodemographic characteristics influence urban identity formation proposing standard measure urban identity social identity formed three dimensions cognitive affective evaluative testing influence urban identity citizens behaviors results show city social representations participate formation process three dimensions urban identity operationalization urban identity second order construct validated urban identity influences citizens behavioral support local initiatives via personal social norms elsevier ltd rights reserved
traction motor electric vehicle required high torque high output density relatively large current applied large current applied large heat generated time heat stator rises value high value characteristic electric motor greatly changed general electric motor production complete control tuned optimal operation tuning control value considered according temperature rise paper interior permanent magnet synchronous motor ipmsm electric vehicle driven characteristic change due temperature rise ipmsm studied mathematically addition proven results using finite elements method fem analysis
biomarkers diagnosis alzheimer disease yet validated use clinical settings aim provide methodological framework systematic validation reference developed oncology biomarkers discipline steps systematic validation biomarkers need target analytical validity clinical validity clinical utility however premises different oncology nature disease neurodegeneration cancer purpose improve diagnosis clinically affected screening preclinical individuals target population mild cognitive impairment patients referring memory clinics general population lead important differences influencing design validation studies use selected biomarkers framework applied within wider initiative assess current available evidence clinical validity biomarkers final aim identify gaps research priorities inform coordinated research efforts boosting biomarkers research elsevier inc rights reserved
objectives study investigates whether trust health care system patient level characteristics associated interest inimmediate initiation long acting reversible contraception larc abortion study design structured self administered survey provided english speaking women years older presenting reproductive health center southeastern united states first trimester surgical abortion survey collected information patient characteristics choice postabortion contraception health literacy trust health care system trust measured using item previously validated survey treated primary independent variable primary outcome variable interest immediate larc placement postabortion statistical analysis performed using chi square tests student tests logistic regression sas results respondents completed survey planned use larc postabortion increased larc placement available day abortion mean trust score possible score differ significantly women indicated interest immediate larc placement postabortion women history prior birth times likely indicate interest immediate postabortion larc others adjusted odds ratio confidence interval conclusion desire accept larc immediately postabortion associated history prior birth trust health care system demographic variables participant interest postabortion larc varied based immediate device availability elsevier inc rights reserved
vascular smooth muscle cell vsmc accumulation hypertrophy common vascular disorders inflammation crucial role development diseases investigate effect inflammation neurotransmission vsmc bioinformatic analysis performed following next generation sequencing genes lipopolysaccharide lps treated cells phosphate buffered saline pbs treated cells sequenced via next generation sequencing assay repeated three times differentially expressed genes degs obtained using noiseq package subsequently potential functions predicted functional pathway enrichment analyses using database annotation visualization integrated discovery online tool interaction relationships proteins enriched pathways associated neurological diseases proteins interaction relationships adrenoceptor adrad calcium voltage gated channel subunit cacnas separately obtained string protein protein interaction ppi networks constructed using cytoscape software total degs including upregulated downregulated genes lps treatment group identified compared control group enrichment analyses showed nadh ubiquinone oxidoreductase core subunit ndufv involved several neurological diseases including oxidative phosphorylation alzheimer disease parkinson disease huntington disease furthermore ndufv degree higher degree ppi network degs enriched pathways associated neurological diseases ppi network adrad cacnas degs interacting prohibitin phb oxytocin receptor oxtr collapsin response mediator protein crmp dihydropyrimidinase like dpysl interaction relationships adrad cacnas conclude present study revealed ndufv phb oxtr crmp dpysl may key roles effect inflammation neurotransmission vsmc
desrvousges investigate criteria judging adequacy scope test differences contingent valuation studies focus particular attention study chapman arguing demonstrated statistically significant scope effect effect small unfortunately dmt misinterpreted chapman error makes dmt criticisms study invalid elsevier rights reserved
paper integrated numerical model established solve complex energy transfer parabolic trough collector ptc combining monte carlo ray tracing finite volume method based model thermal performance ptc using supercritical heat transfer fluid htf studied analyzed results indicate solar fluxes receiver walls non uniform results non uniform temperatures walls moreover optical efficiency achieved normal incidence circumferential temperature difference delta absorber found within typical conditions decreases increasing inlet velocity decreasing inlet temperature studies flow heat transfer characteristic indicate secondary flow occurs cross section due buoyancy velocity secondary flow pseudo critical region one magnitude order larger high temperature region leads strong heat transfer enhancement former studies energy conversion performance indicate ptc achieve collector efficiencies typical conditions brayton rankine cycles respectively efficiency increases decreasing tin increasing additionally corresponding efficiency equations also obtained information study provide reference design operation ptcs using htf elsevier ltd rights reserved
study two objectives one hand analyze relationships empathy prosocial behavior prosocial moral reasoning well differences terms gender hand analyze predictive value variables empathy taken criterion variable sample comprised participants years girls boys comparison means shows significant differences based gender girls expressed higher levels empathy prosocial behavior prosocial moral reasoning dimensions internalized facing necessity stereotyped boys meanwhile show higher rates physical verbal aggressiveness hedonistic approval oriented prosocial moral reasoning regression analysis identified predictors empathy boys girls prosocial behavior hedonistic reasoning prosocial behavior maintains direct relationships empathy case hedonism relationships negative group boys predictors empathy variables positively associated internalized prosocial moral reasoning moral reasoning led need negatively aggressiveness perhaps importantly efficient intervention programs designed foster specific types prosocial behaviors
paper deals control hybrid standalone power generation using micro hydro power turbine mhp coupled squirrel cage induction generator scig solar photovoltaic panel connected common bus three phase voltage source converter vsc terminals vsc connected point common coupling pcc interface inductors battery energy storage system bess also tied common bus buck boost converter proposed system mostly suitable serve power needs small size residential green building situated near small river cannel control algorithms proposed three phase vsc buck boost converter order extract maximum power array single stage conversion regulate voltage frequency pcc improve power quality effectiveness robustness proposed controllers validated simulation using matlab simulink linear nonlinear loads different climate conditions
objectives evaluate changes time drug use among patients undergoing roux gastric bypass rygb surgery matched population based comparison cohort background little known prescription drug use rygb surgery methods nationwide population based cohort study included patients undergoing rygb denmark matched general population members calculated prevalence ratios prs comparing prescription drug use months rygb index date use months date baseline results baseline rygb patients median years males used prescription drug years use decreased slightly among rygb patients confidence interval increased comparison cohort rygb cohort large sustained decreases occurred treatment metabolic syndrome related conditions glucose lowering drug lipid modifying drugs use inhalants obstructive airway diseases also decreased use neuropsychiatric drugs two fold higher baseline rygb cohort increased rygb antidepressants antipsychotics potential treatment neuropathy conclusions three years rygb surgery found large reductions use treatment metabolic syndrome related conditions inhalants obstructive airway diseases glucocorticoid use contrast frequent use neuropsychiatric drugs increased rygb
electric field induced magnetization switching multiferroics holds profound promise ultralow energy computing beyond moore law era bistable nanomagnets multiferroics usually deemed suitable storing binary bit information switching two stable states allows process digital information however requires process continuous analog signals seamless integration nanomagnetic devices future information processing systems show possible harness analog nature magnetostrictive nanomagnets contrary writing digital bit information solving stochastic landau lifshitz gilbert equation magnetization dynamics room temperature demonstrate possibility show exists transistor like high gain region input output characteristics magnetostrictive nanomagnets strain mediated multiferroic composites basis ultralow energy analog mixedsignal precessing future information processing systems eliminates requirement using charge based transistors
anonymous systems internet aim protect users revealing external unauthorized entity identities network activities despite using layered encryption systems still vulnerable timing analysis wherein eavesdropper use traffic correlation mechanisms identify source packets arriving destination mixes intelligent routers proxy servers aim provide packet source anonymity timing analysis delaying shuffling order received packets prior transmission shuffling strategies naturally increase latency result tradeoff anonymity latency paper investigates tradeoff network mixes deriving optimal routing sources maximizes weighted sum anonymity delay achievable anonymity characterized analytically general multipath model shown light traffic conditions exists unique single route strategy achieves optimal delay anonymity tradeoff low complexity algorithm presented derives optimal routes achieve desired tradeoff light traffic results specialized graphical model existing practical anonymous systems optimal scaling behavior size networks characterized heavy traffic regime shown optimal anonymity achieved allocation rates across different routes simulations example networks presented shown optimal routes derived light traffic performs quite well general traffic regime
paper poses problem fabricating physical construction sets example geometry construction set provides small number different types building blocks example model well many similar variants reassembled process formalized tiling grammars core contribution approach simplifying tiling grammars obtain physically manufacturable building blocks controllable granularity retaining variability ability construct many different related shapes simplification performed sequences two types elementary operations non local joint edge collapses tile graphs reduce granularity decomposition approximate replacement operations reduce redundancy evaluate method abstract graph grammars addition computing several physical construction sets manufactured using commodity printer
skills training mass casualty incidents mci shows lack reliable valid assessment criteria therefore feedback incident management based either expert judgment self reflection participants questionnaire developed means support tactical appraisal mci training close methodological gap study four groups emergency medical response personnel carried three mci scenarios rated incident management use likert scale items scale construction relied exploratory factor analysis efa multiple item likert scales tested respect reliability internal consistency measures diagnostic potential scales analyzed exploratory mean scale values comparisons efa revealed model three factors labelled resource allocation goal orientation stress management multiple item likert scales showed satisfactory reliability group comparisons based scale values subsequent exploratory analysis differences scenarios tactical interventions demonstrated diagnostic potential scales new questionnaire used context training debriefing research scales convincing psychometric properties however research effectiveness tactical dimensions still required
vision science teaching framework science education next generation science standards requires radical departure traditional science teaching science literacy defined three dimensional students engage science engineering practices develop apply science disciplinary ideas crosscutting concepts knowledge building presents many challenges teachers describe two pronged program scaling science professional development across state teachers developed expertise learning facilitating teacher study groups peer facilitators led study groups teachers science activities analyzing student learning investigating classroom interactions describe design approaches supporting teacher facilitator learning present analyses teacher learning including shifts science beliefs pedagogical content knowledge supports science teaching consider implications scalable design approaches supporting science teacher learning
estimating observation error covariance matrix properly key step towards successful seismic history matching typically observation errors seismic data spatially correlated therefore observation error covariance matrix non diagonal estimating non diagonal covariance matrix focus current study decompose estimation two steps estimate observation errors construct covariance matrix based estimated observation errors focus step whereas step use procedure similar aanonsen aanonsen step carried using local moving average algorithm treating seismic data image algorithm interpreted discrete convolution image rectangular window function following perspective image processing consider three types image denoising methods namely local moving average different window functions extension method aanonsen non local means denoising wavelet denoising performance three algorithms compared using synthetic field seismic data found investigated cases wavelet denoising method leads best performance time
fundamental process construction cost estimation appropriate adjustment costs reflect project location unfortunately location adjustment factors available locations overcome lack data cost estimators united states often use adjustment factors adjacent locations referred nearest neighbor method however adjacent locations may similar economic conditions limit accuracy method research proposes new method using nighttime light satellite imagery nlsi estimate location adjustment factors exist nlsi method estimating location adjustment factors evaluated established cost index database results show nlsi used effectively estimate location adjustment factors compared alternative proximity based location adjustment methods proposed nlsi method leads reduction median absolute error work contributes body knowledge introducing accurate method estimating location adjustment factors improve cost estimates construction projects location adjustment factors currently exist american society civil engineers
age become increasingly susceptible memory distortions inaccuracies past decade numerous neuroimaging studies attempted illuminate neural underpinnings aging false memory review studies link findings concerning cognitive properties age related changes memory accuracy collectively evidence points towards prominent role age related declines medial temporal prefrontal brain areas corresponding impairments associative binding strategic monitoring resulting cascade cognitive changes contributes heightened vulnerability false memories age including reduced recollective ability reliance gist information familiarity based monitoring mechanisms well reduced ability inhibit irrelevant information erroneous binding features memory traces consider theoretical applied implications research aging false memories well questions remaining addressed future research elsevier ltd rights reserved
objective evaluate impact training reliability among dermatologists rheumatologists assessment psoriatic arthritis psa patients methods overall hospital based rheumatologists hospital based dermatologists met reggio emilia italy october assess psa patients month physicians underwent training session recognized experts assessed different psa patients according modified latin square design measures included tender tjc swollen joint count sjc dactylitis enthesitis schober test psoriasis body surface area bsa psoriasis area severity index pasi nail psoriasis severity index napsi static physician global assessment psa disease activity spga variance components analyses performed estimate intraclass correlation coefficient icc results tjc enthesitis measured pre training dermatologists rheumatologists revealed moderate substantial agreement icc contrast sjc schober test showed fair icc moderate agreement respectively icc poor agreement icc represented dactylitis moderate substantial icc agreement observed skin measures dermatologists rheumatologists apart bsa fair agreement icc observed agreement levels similar training arthritis measures contrast levels agreement training skin measures increased dermatologists skin measures increased rheumatologists conclusions substantial excellent agreement observed tjc enthesitis pasi spga rheumatologists benefited training greater extent elsevier inc rights reserved
objective study aims identify scientific evidence risks effects exposure environmental contaminants children sensitive developmental periods data source search performed bireme database using terms children health environmental exposure health vulnerability toxicity pathways developmental disabilities lilacs medline scielo systems data synthesis children differ adults unique physiological behavioral characteristics potential exposure risks caused several threats environment exposure toxic agents analyzed toxicokinetic processes several systems organs sensitive phases child development caused effects reflected increased prevalence congenital malformations diarrhea asthma cancer endocrine neurological disorders among others negative impacts throughout adult life conclusion identify causes understand mechanisms involved genesis diseases challenge science still lack knowledge children susceptibility many environmental contaminants prevention policies research child environmental health improving recording surveillance environmental risks children health ongoing priority public health field sociedade brasileira pediatria published elsevier editora ltda
article described novel digital multi mode control strategy primary side controlled flyback converter improve efficiency within full load range working modes different load ranges chosen according main power losses analysis constraint especially novel pulse skip mode control method could reduce number actual switching cycles proposed improve light load efficiency prototype field programmable gate array control made verify proposed digital multi mode control strategy
pendulum simple system usually related great discoveries science technology nonlinear dynamics pendulum systems related variety responses objective studies oscillations bifurcations chaos smart material nonlinear effects employed several applications due adaptive behavior presenting great advantages control strategies work deals dynamics sma pendulum system consists pendulum coupled shape memory alloy springs numerical investigation carried exploiting temperature dependent behavior sma complex responses presented possibility thermal control system investigated
deformable part based model dpm shown great success object detection recent years however performance degrade partially occluded objects even worse largely occluded objects real remote sensing applications address problem novel partial configuration object model pcm developed paper compared conventional single layer dpms extra partial configuration layer composed partial configurations defined according possible occlusion patterns introduced pcm block transmission occlusion impact detection hypothesis partial configuration layer infer entire object based spatial interrelationship final detection results obtained fusion possible entire objects using weighted continuous clustering method pcm makes better compromise deformation modeling flexibility small parts discriminative shape capturing capability large dpm performance occluded object detection improved moreover occlusion states detected objects inferred intermediate results model experimental results multiple high resolution remote sensing image datasets demonstrate effectiveness proposed model
disruption neuronal morphology contributes pathology neurodegenerative disorders alzheimer disease however underlying molecular mechanisms unknown show postnatal deletion cdh cofactor anaphase promoting complex cyclosome apc ubiquitin ligase neurons cdh conditional knockout cko disrupts dendrite arborization causes dendritic spine synapse loss cortex hippocampus concomitant memory impairment neurodegeneration adult mice found dendrite destabilizer rho protein kinase rock accumulates brain patients apc cdh substrate vivo rock protein activity increased cortex hippocampus cdh cko mice animals inhibition rock activity using clinically approved drug fasudil prevented dendritic network disorganization memory loss neurodegeneration thus apc cdh mediated degradation rock maintains dendritic network memory formation neuronal survival suggesting pharmacological inhibition aberrantly accumulated rock may suitable therapeutic strategy neurodegeneration
paper discusses application connected pipe system cps suspension bridge china purpose vertical deflection monitoring assessment cps mainly consists three main parts pressure transmitters detect height change liquid pipes connect reference point measurement points liquid fill connected pipes multiple pressure transmitters taken measurement point mounted inside girder reference transmitter mounted inside tower taken fixed point verify performance reliability cps controlled load test completion bridge construction uncontrolled load test actual traffic loading carried results showed cps exhibited excellent capability real time measurement vertical deflection suspension bridge long term deflection data monitored cps extreme deflections respect vehicle loads predicted extreme value analysis generalized extreme value distribution adopted establish probability models daily maximum minimum deflection sequences extreme deflections within design reference period years determined based probability models comparison extreme deflections deflection thresholds carried deflection monitoring assessment method proposed paper shown high potential applicability practice health monitoring long span bridges copyright john wiley sons ltd
paper presents new network architecture delivers thousand broadband service signals base stations establish connection handover procedure subscribers moving railway express
luminescent carbon nanodots cdots attracted much attention luminescence usually quenched solid state efficient green yellow emissive cdot based phosphors scarce work green emissive cdot nacl composite phosphors fabricated convenient low cost eco friendly way embedding green emissive cdots cdot nacl crystals protection nacl host cdot nacl composite phosphors exhibit good photostability significant resistance organic solvents improved photoluminescence quantum yields white light emitting diodes tunable color temperatures cie coordinates realized based cdot nacl composite phosphors elsevier inc rights reserved
hadoop one important big data processing storage systems recent years lot efforts put enhance hadoop performance networking perspectives however limited tools help researchers verify networking algorithm design terms hadoop performance paper proposes doopnet framework toolset creating hadoop clusters virtualized environment monitoring analysing hadoop networking characteristics different network configurations doopnet enables users automatically set hadoop cluster docker containers running inside mininet hadoop traffic collected inside containers virtual switches network flow monitors users easily modify network topologies configurations mininet observe networking behaviour network flow monitors analyse effects different network settings hadoop performance examples presented demonstrate setup doopnet testbed analyse hadoop traffic
solar vapor generation enabled nanoparticles green efficient direct approach utilize solar energy work nanocomposites graphene oxide gold nanoparticles prepared generate solar steam sunlight irradiation changes steam pressure mass loss temperature water used study solar photothermal properties nanocomposites water demonstrated synergistic interaction nanosheets nanoparticles played active role photothermal effect nanocomposites trace nanoparticles parts per thousand nanofluids could signifitantly improve efficiency solar vapor generation interestingly morphology color nanofluids varied irradiation times sunlight results suggested sheets reduced graphene sheets process photothermal deoxygenation provides available solution preparing graphene sheets ambient conditions without reductions solar steam generation method enable potential applications like sterilization waste seawater desalination disinfection elsevier ltd rights reserved
generalized pustular psoriasis gpp severe inflammatory skin disease characterized presence sterile pustules covering almost entire body systemic symptoms fever secukinumab fully human recombinant anti interleukin monoclonal antibody indicated psoriasis vulgaris psoriatic arthritis japan yet investigated gpp phase iii open label multicenter single arm study efficacy safety secukinumab monotherapy medication evaluated japanese patients gpp patients received secukinumab baseline week every weeks two non responders titrated change gpp severity baseline evaluated clinical global impression cgi categorized worsened change minimally improved much improved much improved treatment success achieved patients week primary end point cgi evaluated much improved much improved moreover area erythema pustules improved early week resolved week patients improvements sustained throughout weeks week treatment period secukinumab well tolerated unexpected safety signals nasopharyngitis urticaria diabetes mellitus arthralgia frequent adverse events reported data study shows secukinumab become one potent treatment options gpp
comprehensive assessment systems built environment efficiency casbee home first national voluntary green building program residential structures japan effect builder demographic factors adoption casbee home program investigated since success casbee home heavily reliant usage program study adoption casbee home program home builders modeled two stage process builder awareness preceding actual use casbee home results show firm size type homes built influence japanese builder awareness casbee home program addition respondents participated year house program another voluntary program significantly likely use casbee home finally number years builder business increased awareness usage casbee home program results suggest likelihood adopting casbee home program influenced internal resources available type customers served business experience firm
background important understand costs palliative end life care order inform decisions regarding cost allocation however economic research palliative care limited little known range extent costs involved palliative care provision aim undertake systematic review health social care literature determine range financial costs related palliative care approach explore approaches used measure costs design systematic review empirical literature thematic synthesis study quality evaluated using weight evidence framework data sources databases cinahl cochrane psycinfo medline searched november empirical studies presented data financial costs associated palliative care results total papers met inclusion criteria components palliative care costs incurred within four broad domains hospital care community home based care hospice care informal care costs could considered economic viewpoint three providers state government insurers third party profit organisations patient family society wide variety costing approaches used derive costs conclusion evidence base regarding economics palliative care sparse particularly relating full economic costs palliative care review provides framework considering costs variety economic viewpoints however research required develop refine methodologies
introduction seasonal affective disorder sad psychiatric illness recurring depressive episodes particular seasons mostly winter bupropion effective preventive treatment sad probably also effective acute treatment sad areas covered review covers pharmacokinetics pharmacodynamics bupropion authors also evaluate bupropion clinical efficacy well safety tolerability expert opinion bupropion available immediate release formulation well sustained release formulation extended release formulation formulation recommended sad due ease use formulation currently used therapy due predictable nature sad use bupropion considered relevant treatment option bupropion efficacy shown three trials started autumn time sad symptoms yet present although treatment effects relatively small compared placebo bupropion also shown efficacy open label study said order reach definitive conclusions efficacy acute treatment sad placebo controlled trials needed
central aspect many psychiatric disorders disturbance decision making social interactions disturbance importantly contributes severe social consequences conditions combination economic game theory neuroscience opens potential examine dysfunctional social behavior computational level including psychological social biological information model current studies examine social decision making patients depression bipolar disorder borderline personality disorder autism spectrum disorder using simple social experiments found social decision making less consistent patients borderline personality disorder depressed individuals patients autism controls adult patients autism spectrum disorders showed reduced unconditional altruism experiments patients major depressive disorder specifically exhibited competition avoidance currently examine neural substrate abnormal social decision making using fmri
objective hypersensitivity reactions hsr frequently reported patients rechallenged carboplatin recurrent ovarian cancer roc represent critical issue since discontinuation platinum based therapy could affect prognosis several strategies allow platinum rechallenge described controversial outcomes aim study illustrate year experience cisplatin patients previous hsr carboplatin risk allergy methods retrospective review patients platinum sensitive roc retreated carboplatin performed january may istituto nazionale tumori fondazione pascale naples results among patients presented hsr carboplatin mainly second line therapy mean number cycles hsr range reaction detected patients respectively multivariate analysis including age hystotype brca status previous known hsr combination drug administered type carboplatin based doublet used line therapy found significantly affect hsr development protective effect pld pegylated liposomal doxorubicin thirty seven patients previous hsr carboplatin rechallenged cisplatin treatment generally well tolerated patients experienced mild hsr cisplatin successfully managed cases patients treated cisplatin even without carboplatin related hsr due allergies among one developed hsr conclusions cisplatin rechallenge feasible approach patients experiencing jsr carboplatin maintain beneficial effect platinum reducing hypersensitivity related risks elsevier inc rights reserved
computer programming core subject almost degrees engineering perceived complex matter students different core subjects physics calculus algebra chemistry graphics expression familiar students programming combines balanced way two fundamental steps developing engineering product design implementation coding important difference lower costs implementation phase permits students building testing proposed designs besides new european higher education area ehea based acquisition competencies skills student rather accumulation knowledge use european credit transfer accumulation system ects supposes important challenge teaching model paper show eight years experience developing hybrid methodology teaching computer programming degrees mechanical electrical electronic chemistry engineering university almeria spain integrate traditional teaching methods participative master class transmission information modern methods problem based learning collaborative team working autonomous working tutoring different methods teaching supported hardware software infrastructure virtual teaching blackboard platform detailed planning activities highly focused weekly organized includes periodical tests evaluation progress student think adoption tuning learning methods enhance skills future engineers computer programming area
four dmso complexes substituted flavones viz hydroxy methoxyphenyl chromen one hydroxy nitrophenyl chromen one hydroxy dimethylaminophenyl chromen one hydroxy chlorophenyl chromen one synthesized characterized elemental analysis vis nmr spectroscopies esi molecular structures complexes investigated integrated spectroscopic computational techniques dft ligands well complexes screened anticancer activities breast cancer cell lines mcf cytotoxicity assayed mtt dimethyl thiazol diphenyl tetrazonum bromide assay ligands complexes exhibited significant cytotoxic potential concentration incubation period cell cytotoxicity increased significantly concentration dependent manner series compounds complex induced highest cytotoxicity elsevier rights reserved
reachability standard fractional order continuous time systems piecewise constant inputs addressed necessary sufficient conditions existence piecewise constant inputs steers system zero initial conditions given final state desired time derived proved examples systems electrical circuits switched voltage sources presented
type pneumatic artificial muscle damping seat used crawler construction vehicle introduced pneumatic artificial muscle works nonlinear problem happens often makes working performance become worse therefore self tuning fuzzy pid controller used pneumatic artificial muscle damping seat decrease influence simplified three degrees freedom mathematical model seat vehicle body crawler chassis established vibration damping characteristics pneumatic artificial muscle seat obtained using matlab simulink toolbox four different working conditions crawler construction vehicle vertical accelerations displacements compared new pneumatic artificial muscle damping seat traditional seat simulation results show pneumatic artificial muscle seat could get better damping properties verify analytical model experiments performed roads simulation results show reasonably good agreements experimental data research results could provide references development pneumatic artificial muscle type damping seat
three main magnet systems wendelstein comprising total coils arranged independent circuits fed steady state power supplies superconducting coil system creates main magnetic field consists coils grouped electrical circuits coils inductance similar circuit fed one power supply maximum current maximum voltage second coil system called trim coil system intended enhanced experimental flexibility error field corrections consists five independently powered copper coils placed outer side cryostat operated currents full scale ratings power supply third magnet system divertor control coil system ten normal conducting copper coils situated inside plasma vessel behind divertor targets arranged ten independent circuits current rating one power supply current modulated current frequencies commissioning systems made first using dummy loads finally installed coils final commissioning running since november completed summer
paper discusses model control ionic polymer metal composite ipmc actuators firstly mathematical model ipmc actuator constructed stable second order dynamical system preceded hysteresis representation adaptive controller synthesized ipmc actuator proposed control law ensures global stability controlled ipmc system position error ipmc actuator controlled choosing design parameters experimental results confirm effectiveness proposed method
first order phase transition magnetocaloric materials multi stage regenerators attractive magnetocaloric refrigeration relatively high available power potential use low cost elements iron production work model used represent thermodynamic properties magnetocaloric materials allowing magnetocaloric materials fully parameterized first time numerical model used carry large study including material parameters parameters describe magnetocaloric machines operation unique method evaluating material refrigeration capacity introduced used normalize material inputs results analyzed terms direct impact material parameters interactions machine material parameters performance found machine cooling power maximized cases largest adiabatic temperature changes also found many machine parameters material parameters interact determining performance machine suggests materials machine research would benefit closer collaboration elsevier ltd iir rights reserved
recently novel analytical instrument setup reported automatic preconcentration determination organic compounds various sample matrices based online hollow fiber liquid phase microextraction lpme high performance liquid chromatography hplc present work novel instrument developed extraction determination phthalate esters samples located polyethylene pet bottles using automated syringe pump loading supported liquid membrane slm acceptor solvents platform lift moving sample vial sampling loop online injection extract hplc along electronic board avr microcontroller storage data instrument programs automated sample preparation hplc analysis developed optimization extraction parameters carried box behnken design bbd required minimum experiments entire set experiments performed completely automatically consecutively without human intervention limits detection three times ranged effective preconcentration analytes also achieved method highly precise relative standard deviations varying also accurate recovery percentages main advantages developed method high sensitivity selectivity reliability results minimum sample manipulation full automation suitable extraction time low solvent consumption ease use applicability online automated lpme hplc instrument validated quantitative extraction determination phthalate esters aqueous samples located inside pet bottles
idiopathic pulmonary fibrosis ipf specific form chronic progressive fibroproliferative interstitial pneumonia unknown aetiology disease generally associated poor prognosis several international evidence based guidelines diagnosis management ipf interstitial lung diseases ilds published updated last decade body evidence use treatment modalities grown others shown futile even harmful patients patient presents classic clinical features restrictive ventilatory impairment impaired diffusion high resolution computed tomography hrct scan lungs showing usual interstitial pneumonia uip pattern definitive diagnosis ipf made provided causes radiological uip pattern excluded patients present atypical clinical features hrct pattern classified possible uip referred surgical lung biopsy diagnosis ipf confirmed patient centred approached followed stage disease degree impairment rate disease progression comorbid illnesses patient preferences impact long term management south african thoracic society sats suggests anti fibrotic treatment offered appropriate candidates confirmed ipf forced vital capacity fvc discontinued evidence disease progression decline fvc within month period routine use high dose oral steroids immunosuppressive drugs anticoagulants recommended whilst anti acid therapy may considered patients without advanced disease
objective vasomotor symptoms vms hot flashes night sweats reported many women extent vms genetically determined unknown evaluated relationship genetic variation vms methods observational study accessed data three genome wide association studies gwas snp health association resource cohort share whi memory study cohort whims genome wide association studies treatment response randomized clinical trials garnet studies total european american african american hispanic american postmenopausal women aged years baseline women health initiative study examined genetic variation relation vms yes study using trans ethnic inverse variance fixed effects meta analysis total single nucleotide polymorphisms snps met quality criteria results adjustment covariates population structure three snps chromosomes associated vms genome wide threshold african american share gwas associated cohorts meta analysis snps located chromosome tachykinin receptor tacr locus however snps effect sizes similar across studies participants ancestry odds ratio similar conclusions genetic variation tacr may contribute risk vms knowledge first gwas examine snps associated vms results support biological hypothesis role tacr vms previously hypothesized animal human studies study variants may lead new insights biological pathways involved vms poorly understood
sirtuin sirt member sirtuin family nad dependent deacetylases multiple roles controlling organism homeostasis lifespan diseases due complex opposite functional roles sirtuin considered two edged sword health disease indeed sirt improves longevity similarly founding yeast member silent information regulator sir modulates genome stability telomere integrity transcription dna repair deficiency associated chronic inflammation diabetes cardiac hypertrophy obesity liver dysfunction muscleiadipocyte disorders cancer besides pieces evidence showed sirt promoter specific oncogenic pathways thus disclosing dual role regarding cancer development collectively findings suggest multiple mechanisms date entirely known underlie intriguing roles sirt provide overview current molecular mechanisms sirt controls cancer heart diseases describe recent implications atherosclerotic plaque development elsevier rights reserved
investigate behavior biochemical systems many runs gillespie stochastic simulation algorithm ssa generally needed causing excessive computational costs central processing units cpus since ssa runs independent intel xeon phi coprocessors based many integrated core mic architecture exploited distribute workload considered two execution modalities mic one consisted running exactly cpu code ssa exploited mic vector instructions reuse cpu code modifications mic performance compared graphics processing units gpus specifically implemented cuda optimize use memory hierarchy results show gpu largely outperforms mic cpu required complete redesign ssa mic allows relevant speedup especially vector instructions used additional advantage requiring minimal modifications cpu code
many aspects brain functioning exhibit important sex differences affect behavior mental health mental disorders however translational neuroscience research related animal models neurobehavioral disorders carried male animals based published data laboratory house mouse discuss following issues sex differences social behavior wild derived mice artificial selection laboratory strains consequences social reproductive competition sex dependent effects common experimental procedures differential effects developmental events case endocrine disruption implications female models stress neurobehavioral disorders altogether review data outline marked differences male female responses different social challenges evinces current lack relevant female mouse model social stress whilst animal modelling important approach towards understanding mechanisms neurobehavioral disorders evident data obtained males may irrelevant inferring psychopathology efficacy pharmacological treatments females elsevier ltd rights reserved
background organization long term care one main challenges public health health policies europe worldwide especially terms care concepts people dementia austria czech republic majority elderly institutionalized persons dementia cared nursing homes however unclear many persons living nursing homes austria czech republic suffering cognitive impairment dementia addition basic information nutritional status status mobility medication prescription patterns often missing facilitate new effective evidenced based care concepts basic epidemiological data urgent need thus demdata initiated provide important basic data persons living nursing homes austria czech republic future care planning methods demdata multicentre mixed methods cross sectional study stratified randomly drawn nursing homes austria czech republic surveyed study protocol used study centres assesses four different domains resident care team relative environmental factors resident data include among others health status cognition dementia mobility nutrition behavioural symptoms pain intensity quality life minimum residents per country included study residents care team asked use person centred care burden relatives asked number visits proxy rate quality life family member staff employed nursing homes residents relatives voluntary take part study environmental factors include among others organisational category nursing home number residents number rooms social activities care concept project started march concluded february discussion demdata provide important epidemiological data four different nursing home domains austria czech republic focus prevalence dementia population thereby supplying decision policy makers important foundation future care planning
increasing evidence indicates patients chronic inflammatory arthritis cia including rheumatoid arthritis spondyloarthropathies increased risk arrhythmic events significantly contributing higher cardiovascular disease cvd morbidity mortality observed subjects compared general population although mechanisms accounting arrhythmogenic substrate fully understood main role probably played chronic systemic inflammation able accelerate development structural cvd well directly affect cardiac electrophysiology past decade biologic therapies revolutionized treatment cia highly enhancing probability effectively control disease activity systemic consequences including cardiovascular involvement accordingly accumulating data demonstrated potently inhibiting systemic inflammation biologic drugs reduce cvd progression ameliorate arrhythmic risk parameters putative beneficial impact arrhythmia incidence nevertheless significant number reports clinical trials postmarketing experience suggest medications particularly tnf inhibitor monoclonal antibodies rituximab may circumstances precipitate arrhythmia occurrence probably acutely amplifying myocardial electric instability intrinsically associated diseases review analyze intricate link biologic drugs arrhythmias cia effort identify factors involved fine tuning antiarrhythmic pro arrhythmic balance understand knowledge translated clinical practice obtain favorable benefit risk profile biologic drugs used patients
decide merits social status according functionalist theories emotion nonverbal expressions pride shame play key role functioning automatically perceived status signals view observers automatically make status inferences expressers basis expressions even contradictory contextual information expressers status available four studies authors tested whether implicit explicit status perceptions influenced pride shame expressions even expressions status related messages contradicted contextual information results indicate emotion expressions powerfully influence implicit explicit status inferences times neutralizing even overriding situational knowledge findings demonstrate irrepressible communicative power emotion displays indicate status judgments informed much often automatic responses nonverbal expressions emotion rational contextually bound knowledge
study conducted one university guangzhou mainly examined english majors pragmatic failure verbal nonverbal communication explores possible causes students perspectives combination quantitative method qualitative method employed research including testing questionnaire interviews observation results indicate average pragmatic competence subjects still poor level committed pragmatic failure verbal communication also nonverbal one study explored causes failures learners perspective offered implications research
order improve safe level network security fuzzy neutral network applied optimal attack defense decision firstly theory model attack defense decision system network security based game theory constructed game model attack defense model dynamical game model incomplete information deduced respectively secondly basic theory fuzzy neutral network analyzed framework diagram fuzzy neutral network confirmed model fuzzy membership function constructed thirdly training algorithm fuzzy neutral network based improved genetic algorithm designed computing method every step given detail evaluation suspicious person system carried finally simulation experiments carried results show system profit response efficiency improved fuzzy neutral network obtain higher system profit response efficiency
vivo vitro tests two major ways identifying triggering allergens sensitized individuals allergic symptoms methods equally significant terms sensitivity specificity however certain circumstances vitro methods highly preferred circumvent use sensitizing drugs patients current study described highly sensitive immuno pcr ipcr assay serum ige specific bermuda allergens using oligonucleotide labelled antibody used ipcr sensitive detection serum ige nucleotide sequence amplified using conventional pcr bands visualized agarose gel results demonstrated fold enhancement sensitivity ipcr commercially available enzyme linked immunosorbent assay elisa kit ipcr method highly sensitive bermuda specific serum ige could beneficial allergy clinics elsevier ltd rights reserved
biologic therapies injectable immunomodulatory agents directed specific immune cell chemical targets transformed lives hiv uninfected individuals severe inflammatory conditions including psoriasis rheumatoid arthritis ulcerative colitis perceived increased infection risk associated agents means hiv infected individuals included randomised control trials drugs literature use biologic therapies hiv infected populations limited case reports case series additional data use rituximab monoclonal antibody lymphocytes setting hiv associated haematological malignancy performed systematic review efficacy safety biologic therapy inflammatory conditions hiv infected individuals systematic review identified treatment episodes six different biologic agents encompassing different inflammatory conditions broadly efficacy agents studied comparable reports hiv uninfected patients infectious non infectious sequelae also comparable trial data hiv uninfected patients hiv control even minority individuals receiving anti retroviral therapy art time biologic therapy adversely affected however detail limited concerning art regimens immunological virological parameters follow overall available literature low quality likely subject publication bias successful cases firm conclusions possible regarding efficacy safety biologic agents hiv infected individuals however appear sufficient data warrant inclusion individuals well controlled hiv future trial studies
computer assisted orthopedic surgery allows clinicians better results decreases number early prosthetic replacements nevertheless patient follow pre operative diagnosis post operative control assessed constant referential paper real time algorithm extracts bone edges images derives bony landmarks edges proposed indeed assess real time bone structure positions via ultrasound imaging create useful referential pre operative intra operative post operative measurements assist clinician acquiring bony anatomical landmarks extraction bone soft tissue interface bony landmarks ultrasound images done automatically experimentations performed database images healthy volunteers obtained results showed efficiency stability performance proposed method
recently maturity cloud services development distributed computing increasing images video data stored cloud however cloud services generally provided third party entities addition images video stored cloud mostly depend security cloud servers data encrypted great threat users privacy paper propose method privacy preserving background extraction video surveillance multiple cloud servers based chinese remainder theorem crt client uses crt divide video frame several encrypted frames sent corresponding cloud servers separately cloud servers conduct algorithm visual background extractor vibe encrypted video frames hereafter results obtained transmitted end server results decrypted combined get final extraction results original videos finally results transmitted back client proposed method several advantages based encryption method original extraction method original videos need changed cloud server learns portion video frame information yet recover original video even data leaked multiple cloud servers improve security data enhance processing efficiency experimental results several video surveillance datasets shows method correctly extract background original vibe algorithm protecting privacy client video data
article offers practical ways incorporate healthy sleep education pediatric practice discusses key questions barriers strategies associated efforts rationale incorporating healthy sleep education pediatric practice settings presented desirable features sleep education programs may implemented pediatric practice identified potential barriers reviewed strategies offered overcome barriers developing resources applicable healthy sleep education practical information pediatricians key factors regarding effectiveness interventional programs key points relevant successful healthy sleep education pediatric practice highlighted
purpose evaluate image quality anatomical detail depiction dose reduced digital plain chest radiograms using new needle screen storage phosphor nip comparison full dose conventional powder screen storage phosphor pip images materials methods supine chest radiograms obtained pip standard dose compared follow studies patients obtained nip dose reduced pip dose imaging systems agfa gevaert mortsel belgium systems identical versions post processing software supplied manufacturer used matched parameters six independent readers blinded modality dose evaluated images depiction differentiation defined anatomical regions peripheral lung parenchyma central lung parenchyma hilum heart diaphragm upper mediastinum bone nip images compared corresponding pip images using five point scale clearly inferior clearly superior overall image quality rated pip nip image separately usable excellent results pip dose reduced nip images rated equivalent mean image noise impression slightly higher nip images mean image quality nip showed significant differences mann whitney test conclusion use new needle structured storage phosphors chest radiography dose reduction possible without detracting image quality detail depiction especially patients multiple follow studies overall dose decreased significantly
objectives women reproductive age commonly use hormonal contraceptives vocal effects studied otolaryngologists aware relationship make recommendations hormonal contraception relates patient voice requirements methods design comprehensive literature review pubmed completed terms contraception vocal folds vocal cords voice searched various combinations articles addressed effects contraception vocal folds included results total articles available review historically contraception believed affect voice negatively however recent studies using low dose oral contraceptive pills ocps show stabilize voice however stabilization generally occurs sustained vowel production connected speech appears unaffected therefore singers may population experiences clinically increased vocal stability result taking hormonal contraceptives combined ocps studied forms hormonal contraception evaluated effects voice significant variability exists studies physical attributes patients parameters tested conclusions hormonal contraception likely clinically perceptible effects speaking voice singers may experience increased vocal stability low dose combined ocp use available forms contraception studied greater consistency methodology needed future research forms hormonal contraception require study
myeloproliferative neoplasms mpns diseases excess cell proliferation bone marrow precursors two classic mpns polycythemia vera essential thrombocytosis conditions excess proliferation red blood cells platelets respectively although involve different cells myeloid lineage clinical presentations shared features consistent overlapping mutations growth factor signaling management diseases involves minimizing risk thrombotic hemorrhagic complications progress myelofibrosis acute myeloid leukemia portending poor prognosis mpns also present primary myelofibrosis
exposure air pollution claimed lives seven million people worldwide largely combustion solid biomass fuels bioenergy alternative renewable source mitigate climate change little known human health ecosystem effects bioenergy mainly electricity sector research applied life cycle assessment approach examine human health ecosystem effects four bioenergy pathways direct combustion wood biomass direct combustion forest residue direct combustion pellets biomass integrated gasification combined cycle bigcc pathways showed variability impacts therefore single bioenergy pathway best absolute option exception slightly higher human health impact bigcc least impact impact categories however bioenergy systems implied lower ecosystem impact higher human health impact compared climate change impact electricity generation wood biomass would improve environmental sustainability alberta electricity grid system reduces human health ecosystem impacts compared existing electricity production mix province elsevier ltd rights reserved
nps care patients chronic diseases heart failure chronic obstructive pulmonary disease cancer dementia disease progresses patients age disease related symptoms may become increasingly burdensome patients may benefit hospice palliative care nps guide individuals process optimize care support end life
construction projects become larger complex develop different features smaller traditional projects characterize complex systems still construction engineering management cem researchers mostly relied traditional approaches investigate complex management problems might produce misleading results paper introduces agent based modeling simulation abms research method addresses could applied cem research illustrative example application abms cem research theoretical background well design development test processes abms presented made recommendation promising research subjects cem area abms could suitably applied
wireless network security becoming great challenge popularity high spirit account open medium insignificant software implementation potential hardware deficits improper configuration network vulnerable rogue access point rap rogue access point unauthorized access point installed end users without knowledge security administrator rogue device connected internet used assailant breach security network existing raps detection techniques limited capabilities able detect variants assaulters activities paper method named honeypot intrusion detection system honeypot ids proposed detection prevention rogue access point via attack detection performed internal external malicious users honeypot ids combines intrusion detection system honeypot reduce false alarm rate generated existing ids proposed approach consist three phases filtering intrusion detection system honeypot traffic passing filtering intrusion detection system rerouted honeypot depth investigation proposed architecture improves overall performance system diminishing false alarm rate generated intrusion detection system able sustain overall workload honeypot
internet things based sensors communication networks intelligence manages entire process generated data sensors senses systems used large quantities sensors must low power consumption cost small size great flexibility use circumstances therefore security network devices data sensors devices major concern grows rapidly terms nodes interconnected via sensor data paper presents analysis systematic review point view articles internet things iot security aspects specifically privacy level control access type environment finally presents analysis security issues must addressed different clusters identified areas within fields application technology
models humans commonly used within computer graphics vision ability distinguish body shapes important shape retrieval problem extend recent paper provided benchmark testing non rigid shape retrieval algorithms human models benchmark provided far stricter challenge previous shape benchmarks added new models use separate training set order standardise training data used provide fairer comparison also included experiments faust dataset human scans participants previous benchmark study taken part new tests reported many providing updated results using new data addition participants also taken part provide extra analysis retrieval results total different shape retrieval methods compared
fluid mechanics microfluidics distinctively simpler fluid mechanics macroscopic systems macroscopic systems effects non laminar flow convection gravity etc need accounted usually neglected microfluidic systems still exists limited selection channel cross sections navier stokes equation pressure driven poiseuille flow solved analytically equations velocity profiles well flow rates calculated however whenever cross section highly symmetric rectangular elliptical circular navier stokes equation usually solved analytically cases numerical methods required however many instances necessary turn complex numerical solver packages deriving velocity profile complex microfluidic channel cross section paper simple spreadsheet analysis tool microsoft excel used implement simple numerical scheme allows solving navier stokes equation arbitrary channel cross sections
growing global concern environment one hand alarming danger carbon footprint generation along non biodegradability higher toxicity generation use synthetic fibres created dire need come back natural fibres application fabrics sites geotextile application even designing garments apparel sector observed ability fabric assume graceful appearance contour crucial conveying significance drapeability natural fibre made fabric attempt made work evaluate effect different weave constructions drapeability jute woven fabrics justify application sites
background impact changing non verbal consultation behaviours unknown aim assess brief physician training improving predominantly non verbal communication design setting cluster randomised parallel group trial among adults aged years attending general practices close study coordinating centres southampton method sixteen gps randomised training training consisting brief presentation behaviours identified prior study acronym kepe warm demonstrating knowledge patient encouraging back channelling saying hmm example physically engaging touch gestures slight lean warm cool professional initially warming avoiding distancing non verbal cut offs end consultation encouragement reflect videos consultation outcomes medical interview satisfaction scale miss mean item score patients perceptions domains communication results intervention participants scored higher miss overall confidence interval largest changes distress relief perceived relationship subscales significant improvement occurred perceived communication partnership health promotion non significant improvements occurred perceptions personal relationship positive approach understanding effects illness life conclusion brief training gps predominantly nonverbal communication consultation reflection consultation videotapes improves patients perceptions satisfaction distress partnership approach health promotion
chronotherapeutics wake therapy bright light therapy well established methods treating adults depressive disorders additionally beneficent sleep regulation studies concerning chronotherapeutics juvenile depression exist though established treatments insufficient sleep disorders often occur study investigate impact two types chronotherapeutics depressive symptoms sleep behavior juvenile setting juvenile inpatients moderate severe depressive symptoms took part either combined setting consisting one night wake therapy followed weeks bright light therapy setting bright light therapy alone depressive symptoms general psychopathology clinical impression sleep behavior measured directly weeks intervention depressive symptoms decreased sleep quality increased groups bright light therapy alone group showed improvement regards depressive symptoms correlation analyses indicated significant negative correlations sleep quality awaking restorative sleep depressive symptoms however awaking restorative sleep predictive impact treatment outcome present study provides first evidence positive impact chronotherapeutic interventions treatment outcome depressed juvenile inpatients bright light therapy seems stabilize enhance reduction depressive symptoms follow whereas one night wake therapy additional long lasting impact depressive symptoms sleep parameters
simprogramming teaching approach goal help students overcome learning difficulties transition entry level advanced computer programming prepare real world labour environments adopting learning strategies immerses learners businesslike learning environment students develop problem based learning activity specific set tasks one filling weekly individual forms conducted thematic analysis weekly forms identify students strategies self regulation learning assignment students adopting different strategies phase approach early phases devoted organization planning later phases focus applying theoretical knowledge hands programming based results recommend development educational practices help students conduct self reflection performance tasks
multicultural ideology proposes group memberships acknowledged also valued order accommodate diversity attain equality three studies conducted spain canada analyzed using different measures relationship multicultural ideology one hand prejudice support social policies motivation social change hand spain focused responses gitanos spanish roma canada first nations people results showed multicultural ideology related cases lower prejudice higher support social policies support minority group motivation social change internal motivation control prejudice important mediator relationship countries contrast way social identities represented played different role function country whereas dual identity representation played mediating role canada common identity representation mediator spain results support importance valuing cultural diversity harmonize intergroup relations reduce inequalities majorities minority groups elsevier ltd rights reserved
paper presents computational model nonlinear two degree freedom dof robotic leg model based mathematical model two connected body segments mimic lower thigh shank human leg two sets electro hydraulic servo systems ehss seperately used drive robotic thigh shank dynamic ehss accurately developed exhibit relationship input current actuated force torque velocity observer used estimate angular velocities robotic thigh shank velocity feedback controller proposed track hip knee joints movements robotic leg simulation results show velocity feedback controller gives better tracking performances term position control strategy compared conventional pid controller
literature review summarizes significant technical literature published primary areas urban wet weather flows review covers range topics including characterization pollution sources monitoring sampling surface groundwater impacts mathematical modeling tools decision support systems regulatory policies control treatment technologies gaps literature compilation also identified presented support future research efforts
study investigated whether use thought control strategies specific suicidal thoughts influenced suicide ideation suicide risk sample adult students selectively recruited endorsing history suicide ideation pre screen assessment adapted version thought control questionnaire tcq wells davies specific controlling thoughts suicide employed assess whether participants responded thoughts suicide worry self punishment reappraisal concealment distraction suicide specific thought control questionnaire demonstrated reliable factor structure similar original measure results indicated distraction suicidal thoughts negatively correlated suicide ideation risk whereas self punishment thoughts worrying thoughts positively correlated suicide ideation suicide risk clinical implications future research directions discussed elsevier ltd rights reserved
traditional critical conduction mode crm flyback pfc converter constant time control strategy usually suffers low power factor high total harmonic distortion thd due nonsinusoidal input current waveform order solve problem improved variable time control strategy crm flyback pfc converter proposed letter simple analog divider circuit consisting operational amplifier two signal switches filter proposed modulate turn time primary switch thd crm flyback pfc converter evidently improved theoretical analysis presented experiment results verify advantages proposed control scheme
present electrostatically driven four electrode micropump operates peristaltic motion working fluid gas particular focus characteristics micropump function various actuating signals four flexible electrodes micropump operated customized pulse signal whereas maximum flow rate using basic actuating signal approximately min maximum flow rate using optimized actuating signal approximately min increase approximately times minimum flow rate various actuating signals generated microcontroller unit mcu equipped logic circuit high voltage power supply function generator minimum flow rate occurs four pumping sequence three electrodes however maximum flow rate occurs four electrodes participate sequentially proposed micropump consists single chamber flexible membrane four electrodes chamber divided smaller cells embedded electrodes controlled custom made logic circuit generates various phase sequencing actuation signals micropump applicable gas chromatography elsevier rights reserved
background graphical models long used describe biological networks variety important tasks determination key biological parameters structure graphical model ultimately determines whether unknown parameters unambiguously obtained experimental observations identifiability problem limited resources technical capacities complex biological networks usually partially observed experiment thus introduces latent variables corresponding graphical models number previous studies tackled parameter identifiability problem graphical models linear structural equation models sems without latent variables however limited resolution efficiency existing approaches necessarily calls development novel structural identifiability analysis algorithms results efficient structural identifiability analysis algorithm developed study broad range network structures proposed method adopts wright path coefficient method generate identifiability equations forms symbolic polynomials converts symbolic equations binary matrices called identifiability matrix several matrix operations introduced identifiability matrix reduction system equivalency maintained based reduced identifiability matrices structural identifiability parameter determined number benchmark models used verify validity proposed approach finally network module influenza virus replication employed real example illustrate application proposed approach practice conclusions proposed approach deal cyclic networks latent variables key advantage intentionally avoids symbolic computation thus highly efficient also method capable determining identifiability single parameter thus higher resolution comparison many existing approaches overall study provides basis systematic examination refinement graphical models biological networks identifiability point view significant potential extended complex network structures high dimensional systems
wireless sensor networks data harvesting using mobile data ferries recently emerged promising alternative traditional multi hop communication paradigm use data ferries significantly reduce energy consumption sensor nodes increase network lifetime however usually incurs long data delivery latency data ferry needs travel network collect data delay sensitive data may become obsolete therefore important optimize trajectory data ferry data delivery latency bound approach effective practice address problem formally define time constrained data harvesting problem seeks optimal data harvesting path network collect much data possible within time duration investigate formulated data harvesting problem generic dimensional context cases particularly pertinent first characterize performance bound given optimal data harvesting algorithm show optimal algorithm significantly outperforms random algorithm especially network scales however mathematically prove finding optimal data harvesting path hard therefore devise approximation algorithm mathematically prove output constant factor approximation optimal solution experimental results also demonstrate approximation algorithm significantly outperforms random algorithm wide range network settings
recent years development network information reform development education played great role promoting present mobile internet becoming number one choice access information communication way development mobile internet information technology development education sector provide opportunities mobile fragmented individualized education socializing features new mobile internet era education young students mainstream mobile internet user base also direct object english teaching traditional english teaching model meet needs young students mobile internet applications english teaching currently facing major college english teaching problem paper efficiency learning mobile internet era reform college english teaching improve college english outside classroom depth discussion research put forward corresponding strategies methods reform first recognize mobile internet mobile internet mobile communications internet combine two one open highlight era mobile terminal equipment inject huge amounts energy development mobile internet mobile internet industry bring unprecedented leap mobile internet smart mobile terminal using mobile wireless communications services obtain business emerging business including terminals software applications three levels terminal layer including smart phones tablet pcs books mid etc software including operating systems middleware database security software application layer including casual entertainment media tools business finance culture education etc different applications services january total number china mobile internet users reached million mobile phone user penetration rate scale mobile phone users reached million eighty percent total number internet users phone maintains first big internet terminal status development china mobile internet era universal according chinese mobile internet users research reports statistics million mobile internet users groups students main force accounting ratio
gaussian process regression models make powerful predictors sample exercises cubic runtimes dense matrix decompositions severely limit size data training testing deployed means computer experiment spatial geo physical machine learning contexts gps longer enjoy privileged status data sets continue balloon size discuss implementation local approximate gaussian process models lagp package offers particular sparse matrix remedy uniquely positioned leverage modern parallel computing architectures lagp approach seen update spatial statistical method local kriging neighborhoods briefly review method provide extensive illustrations features package worked code examples appendix covers custom building options symmetric multi processor graphical processing units built wrapper routines automate distribution simple network workstations
compared position fixed fish feeding machine shrimp feeding requires bait spread evenly across whole pond water surface since domain characteristic low activity ability less feeding machine meet goal solve problem paper throwing tray designed based bait particles moving curve simulation experiment achieve even spreading bait new feeding machine upgraded meet requirement installation operation boat driving system power source calculated assembled experiment conducted practical shrimp cultivation performance result shows validation
spreading depolarization generates significant alterations cerebral haemodynamics detrimental consequences brain function integrity ketamine shown important capacity modulate however impact haemodynamic response incompletely understood investigated effect two therapeutic ketamine dosages low dose high dose haemodynamic response gyrencephalic swine brain cerebral blood volume pial arterial diameter cerebral blood flow assessed intrinsic optical signal imaging laser doppler flowmetry findings indicate frequent sds caused persistent increase baseline pial arterial diameter lead diminished capacity dilate ketamine infused low dose reduced hyperemic vasodilative response however alter subsequent oligemic vasoconstrictive response low dose prevent baseline diameter increase diminished dilative capacity infusion ketamine high dose suppressed coupled haemodynamic response therefore haemodynamic response modulated continuous infusion ketamine however use pathological models needs explored corroborate possible clinical benefit
paper presents different methods solve short term load forecasting problem smart grids smart grid electrical network monitored managed effective efficient use energy low cost planning oriented management required smart grids one important helpers power management forecast load correctly load forecasting demand response energy prices affect time load forecasting important role safely operating conditions power systems control study effects load forecasting real network operating conditions examined also time series mathematical model heuristic models developed load forecasting performances forecasting models developed compared actual values
modern discrete gpus processors choice accelerating compute intensive applications using large scale data processing extremely challenging unfortunately provide important abstractions long established cpu context memory mapped files shield programmers complexity buffer device management however implementing abstractions gpus poses problem limited gpu virtual memory system provides address space management page fault handling mechanisms gpu developers allow modifications memory mappings running gpu programs implement activepointers software address translation layer paging system introduces native support page faults virtual address space management gpu programs enables implementation fully functional memory mapped files commodity gpus files mapped gpu memory accessed using active pointers behave like regular pointers access gpu page cache hood trigger page faults handled gpu design evaluate number novel mechanisms including translation cache hardware registers translation aggregation deadlock free page fault handling threads single warp extensively evaluate activepointers commodity nvidia gpus using microbenchmarks also implement complex image processing application constructs photo collage subset million images stored file gpu implementation maps entire file gpu memory accesses via active pointers use active pointers adds application runtime enabling speedups combined cpu gpu implementation core cpu implementation uses avx vector instructions
proliferation unstructured data inability relational databases handle data efficient manner non relational databases gained importance last decade paper provides brief description non relational database characteristics explains important features mongodb oracle nosql databases provides guidance decision makers want use choose two databases enterprise applications
pid control schemes widely employed industrial processes however important choose suitable set pid gains included pid controller control performance strongly depends pid gains single input single output systems data oriented control schemes without using system model computing pid gains proposed paper proposed scheme extended multi input multi output case pid gains included multivariable pid controllers derived using operating data result suitable set pid gains obtained enables system output track reference model output behavior proposed scheme examined numerical simulation examples wiley periodicals inc
based extended three wave approach hirota bilinear method dimensional boiti leon manna pempinelli equation investigated aid symbolic computation three wave solutions including kinky periodic solitarywave solutions periodic soliton solutions kink solutions presented figures corresponding solutions illustrated show abundant physics structures solutions enrich sorts dynamics nonlinear wave model
schizophrenia elevates risk aggressive behavior violent crime however aggression schizophrenia heterogeneous origin different pathways leading aggressive behavior special subgroup violent offenders taken account treatment planning risk management treat schizophrenic delinquents way schizophrenics general psychiatry effective small group forensic patients majority schizophrenic offenders show additional problems neurocognitive impairment high rates side effects psychopharmacological treatment persistent positive symptoms substance abuse conduct disorder comorbid antisocial personality disorder psychopathy stressful experiences adult life interaction factors results general lack adherence therapy one important risk factors relapse psychosis recidivism effective treatment psychotic offenders takes problems account accepting severe obstacles positive treatment outcomes therefore modern forensic therapy schizophrenia designed address problems order improve overall treatment motivation
uncontrolled nature user assigned tags makes prone various inconsistencies caused spelling variations synonyms acronyms hyponyms inconsistencies turn lead common problems associated use folksonomies tag explosion phenomenon mapping user tags corresponding wikipedia articles well formed concepts offers multifaceted benefits process subject metadata generation management wide range online environments include normalization inconsistencies elimination personal tags improvement interchangeability existing subject metadata article propose machine learning based method capable automatic mapping user tags equivalent wikipedia concepts demonstrated application proposed method evaluated performance using currently popular computer programming website stackoverflow com test platform currently around million posts stackoverflow annotated unique user tags chosen subset tags evaluate accuracy performance proposed mapping method evaluated performance method using standard information retrieval measures precision recall depending machine learning based classification algorithm used part mapping process scores high achieved
evaluate multiparametric mri mpmri derived histogram textural analysis parameters detection transition zone prostatic tumour sixty seven consecutive men suspected prostate cancer underwent mpmri prior template mapping biopsy tpm twenty six men significant tumour two radiologists consensus matched tpm single axial slice best depicting tumour largest diameter benign histology define single slice whole regions interest rois textural parameter differences single slice whole roi containing significant tumour versus benign insignificant tumour analysed using mann whitney test diagnostic accuracy assessed receiver operating characteristic area curve roc auc analysis cross validated leave one loo analysis adc kurtosis significantly lower containing significant tumour roc auc loo auc difference became non significant following exclusion significant tumour single slice whole roi entropy significantly lower containing significant tumour roc auc loo auc unaffected excluding significant tumour roi combining parameters yielded roc auc loo auc textural features whole prostate discriminate significant prostatic cancer reduced kurtosis adc histogram significant tumour included roi reduced entropy independent tumour inclusion aeuro cent textural features prostate transition zone may discriminate significant prostatic cancer aeuro cent transition zone containing significant tumour demonstrates less peaked adc histogram aeuro cent containing significant tumour reveals higher post contrast weighted homogeneity aeuro cent utility texture analysis prostate cancer merits investigation
purpose purpose paper examine knowledge attitudes preconception health care among chinese immigrants canada design methodology approach cross sectional internet based survey informed principles health belief model administered convenience sample ottawa canada total respondents chinese community participated online survey findings overall participants demonstrated low moderate awareness preconception related risk factors preconception health neutral slightly positive attitudes toward carrying preconception care considerable confusion differences among preconception care premarital health care mainland china prenatal health care great sensitivity subjective norms related spouses parents friends strong desire receiving information communication health care professionals practical implications emphasis reducing misperceptions offering information preconception period potential severe pregnancy related risks may contribute better knowledge intended behavior toward preconception care among chinese immigrants ultimately optimize reproductive health future children health originality value cultural norms population policies sending country may frame immigrants knowledge attitudes related preconception health care study fills gap literature regarding chinese immigrants knowledge levels attitudes toward preconception care canada thus offers insights deliver culturally competent care design effective communication strategies reach ethnocultural communities
permanent magnet motors rare earth magnets among best candidates high performance applications automotive applications however due cost risks relating security supply alternative solutions ferrite magnets recently become popular paper two major design challenges using ferrite magnets high torque density high speed application low remanent flux density low coercivity addressed shown spoke type design utilizing distributed winding may overcome torque density challenge due simultaneous flux concentration reluctance torque possibility furthermore demagnetization challenge overcome careful optimization rotor structure inclusion nonmagnetic voids top bottom magnets meet challenges high speed operation extensive rotor structural analysis undertaken electromagnetics manufacturing tolerances taken account electromagnetic studies validated testing prototype custom built static torque demagnetization evaluation disclosed motor design surpasses state art performance cost merging theories multidisciplinary product
increasing number brain imaging studies genetic studies revealing structural functional impairments genetic risk factors criminal offenders review outlines recent neurobiological findings offenders antisocial personality disorder regard studies implications neurobiological research forensic psychiatry criminology discussed increasing knowledge neurosciences provides better understanding biological underpinnings delinquent behaviour nevertheless kept mind antisocial behaviour undoubtedly arises complex pattern biological psychological social situative factors
patients inadequate health literacy medical comorbidities previous history adverse drug events higher likelihood non adherence osteoporosis treatment sustaining distal radius fracture introduction patients distal radial fracture drf higher risk subsequent fractures provides important opportunity begin treatment osteoporosis study assessed effect health literacy patients suffering drf subsequent adherence osteoporosis treatment methods total patients female years age presenting drf caused low energy trauma enrolled health literacy measured using newest vital sign nvs alendronate orally weekly prescribed patients year adherence defined taking least tablets months returning visit month multivariable analyses conducted determine whether patients clinical demographic health literacy factors influenced adherence osteoporosis treatment results half participants sustained drf exhibited inadequate health literacy rate non adherence osteoporosis treatment rate non adherence patients inadequate literacy significantly higher appropriate literacy results regression analysis indicate limited health literacy presence comorbidities prior history adverse drug events associated higher likelihood non adherence osteoporosis treatment sustaining drf conclusions patients inadequate health literacy adverse drug events medical comorbidities higher rates non adherence alendronate treatment sustaining drf research needed show whether improvements patient comprehension via informational intervention patients drf improve adherence osteoporosis treatment
classical swine fever csf highly contagious swine infectious disease causes significant economic losses pig industry worldwide objective study determine whether small molecule metabolites contribute pathogenesis csf birefly serum metabolomics csfv shimen strain infected piglets analyzed ultraperformance liquid chromatography electrospray ionization time flight mass spectrometry uplc esi tof combination multivariate statistical analysis csfv infected piglets days post infection changes found metabolites associated several key metabolic pathways including tryptophan catabolism kynurenine pathway phenylalanine metabolism fatty acid lipid metabolism tricarboxylic acid urea cycles branched chain amino acid metabolism nucleotide metabolism several pathways involved energy metabolism including fatty acid biosynthesis beta oxidation branched chain amino acid metabolism tricarboxylic acid cycle significantly inhibited changes also observed several metabolites exclusively associated gut microbiota metabolomic profiles indicate csfv host gut microbiome interactions play role development csf
mild traumatic brain injury mtbi concussion terms often used interchangeably however mtbi frequently seen representing broader injury encompasses construct concussion often conveys transience decreased severity present study examined influence varying diagnostic terminology acute injury expectations undergraduate population participants presented mtbi vignette randomly assigned one two conditions term mtbi concussion used describe injury significant differences two conditions anxiety symptomatology timeline consequence scales however participants mtbi group allocated days return play participants concussion group suggesting terminology effect perceptions severity injury varsity athletes allocated fewer days return play nonathletes individuals history concussion athletes nonathletes indicated fewer days return play greater symptomatology individuals history concussion clinicians consider influence diagnostic terminology athletic background history concussion perceptions severity injury expectations influence injury outcomes compliance recovery process
present work biosensor built smart material based polymer brushes biosensor demonstrated sensitive property used control modulate electrochemical responses biosensor property could used realize controlled electrochemical reaction hydrogen peroxide hrp immobilized polymer brushes composite film also showed excellent amperometric response toward hydrogen peroxide concentration range future platform might used self regulating targeted diagnostic drug delivery biofuel cell based controllable bioelectrocatalysis elsevier rights reserved
interleukin cytokine secreted several cell types important physiological roles activity proliferation viability immune cells chemoattractant proinflammatory properties may promote bone destruction previous study shown alone exerts effect osteoclastogenesis therefore current study addressed synergistic effect osteoclast formation using raw raw cells stimulation receptor activator nuclear factor ligand rankl major role osteoclastogenesis involving pathogenesis rheumatoid arthritis periodontal disease stimulation raw cells rankl significantly increased gene expression osteoclast differentiation osteoclastogenesis markers compared stimulation rankl independently evaluated tartrate resistant acid phosphate positive cell numbers fusion index pit formation assay alizarin red staining calcification estimation quantitative polymerase chain reaction phosphorylation extracellular signal regulated kinase erk junn terminal kinase mitogen activated protein kinase significantly increased rankl compared rankl alone addition differentiation activities induced rankl comparatively suppressed inhibition erk suggesting synergistic effect osteoclastogenesis mainly mediated erk taken together results demonstrate rankl induce osteoclastogenesis synergistically might play novel major role destructive inflammatory bone diseases wiley periodicals inc
background ukraine hiv epidemic concentrated among people inject drugs pwid however coverage opioid agonist therapies oats available mostly specialty addiction clinics extremely low oat integrated primary healthcare clinics phcs provides opportunity integrating comprehensive healthcare services scaling oat methods pilot study phc based integrated care drug users conducted two ukrainian cities included three sub studies cross sectional treatment site preference assessment among current oat patients observational cohort pwid continued standard care versus transition stabilized newly enrolled pwid phc based integrated care pre post analysis attitudes toward pwid hiv patients phc staff results among oat patients preferred receiving oat phcs independently correlated convenience trust physician treatment methadone buprenorphine pwid observed months retention treatment high pwid continuing oat specialty addiction treatment settings standard care pwid transitioning phcs among pwid newly initiating oat phcs overall satisfaction treatment subjective self perception well trust physician significantly increased patients prescribed oat phcs among phc staff attitudes towards pwid hiv patients significantly improved time conclusions oat successfully integrated primary care low middle income countries improves outcomes patients clinicians potentially scaling oat pwid elsevier rights reserved
research compared efficacy two parenting interventions vary according number nature variables reducing preschoolers externalizing behavior goal identify parenting intervention format one variable versus two variable caused higher behavioral adjustment children first one variable intervention manipulating parental self efficacy beliefs second two variable intervention manipulating parents self efficacy beliefs emotion coaching practices two interventions shared exactly design consisting eight parent group sessions effect children observed behaviors evaluated multi method assessment three points pre test post test follow results highlighted compared waitlist condition two intervention formats tended cause significant reduction children reported parent however one variable intervention found lead greater decrease children follow opposite reported children observed behavior improved greater extent two variable intervention post test follow results illustrated interventions format considered purely interchangeable since impact children behavior modification different results discussed research clinical implications elsevier ltd rights reserved
although many studies adverse health effects substance use hiv disease progression similar studies caffeine consumption study investigated effects caffeine immunological virological markers hiv disease progression convenience sample clinically stable people living hiv aids antiretroviral therapy consuming day caffeine recruited miami adult studies hiv mash cohort study included baseline month follow visit demographics body composition measures substance use modified caffeine consumption questionnaire mccq count hiv viral load obtained participants multivariable linear regression linear mixed models lmms used understand effect caffeine consumption count hiv viral load mean age cohort years men african americans participants art visits mean caffeine intake baseline day change significantly month follow visit multivariable linear regressions adjustment covariates showed significant association caffeine consumption higher count beta lower hiv viral load beta lmm adjustment covariates showed relationship caffeine count beta hiv viral load beta continued time dose response manner higher caffeine consumption associated higher cell counts lower hiv viral loads indicating beneficial effects hiv disease progression studies examining biochemical effects caffeine cell counts viral replication need done future
poly butylene adipate terephthalate pbat blended poly propylene carbonate ppc twin screw extruder blends made onto films via blown film technique ppc dispersed uniformly pbat matrix glass transition temperature pbat decreased increasing content ppc wide angle ray diffraction confirmed crystallite dimension pbat decreased blending pbat amorphous ppc results mechanical tests indicated pbat ppc films showed high tensile strength tear strength addition pbat ppc films showed high carbon dioxide permeability moderate oxygen nitrogen permeability embedding soil weight loss mechanical properties analysis demonstrated films remarkably biodegraded findings contributed application biodegradable materials design manufacture polymer packaging
win french people consumed nearly billion euros worth drugs resulting growing burden french social security expenses refunded public health insurance amount billion euros total cost drug purchase french authorities point need rational prescribing especially concerning psychotropic drugs data prescription second generation antidepressants sga synthesized clinicians use objective study offer description effectiveness tolerability acceptability sga according data recent meta analyzes method sga searched latest meta analysis medline present web science present cochrane journals results considering benefit risk ratio cost generic first line treatment major depressive episode may currently sertraline day may however digestive side effects ssris due serotonin action calls caution increasing doses four effective antidepressants may order mirtazapine escitalopram venlafaxine sertraline escitalopram sertraline may show better acceptability profile mirtaapine duloxetine fluvoxamine paroxetine venlafaxine fluoxetine seems relevant treatment negative symptoms schizophrenia day bulimia day fluvoxamine seems relevant case sexual side effects previous ssri treatment anxiety disorders affinity sigma receptors may confer specific action psychotic depression mirtazapine may treatment interest fast remission depressive symptoms warranted tolerance profile makes difficult use found meta analysis comparing efficacy tolerability duloxetine antidepressants probably due recent availability molecule found arguments favor first prescription tianeptine except perhaps better safety profile data scarce presence generalized anxiety disorder indication start treatment half doses days whatever molecule avoid resurgence anxious symptomatology prescription antidepressants demonstrated efficacy major depressive episode anxiety disorders molecules dysthymia seasonal affective disorder sad efficiency dysthymia may explain prescription antidepressants exceed scope marketing authorization conclusion summarize article current data recent meta analyzes regarding effectiveness tolerance acceptability sga help practitioners choices prescription elsevier masson sas rights reserved
background purposeapremilast oral nonbiologic medication approved treatment adult patients active psoriatic arthritis patients moderate severe plaque psoriasis article summarizes efficacy safety apremilast provides characterization novel medication clinical perspectives successfully incorporate therapy practice appropriate patients data sourcesa review synthesis results esteem efficacy safety trial evaluating effects apremilast psoriasis phase clinical studies evaluating efficacy safety tolerability apremilast treatment moderate severe plaque psoriasis conducted conclusionsresults esteem clinical trial program demonstrate apremilast significantly reduces severity moderate severe plaque psoriasis acceptable safety profile generally well tolerated implications practicethe novel mechanism action convenience oral administration acceptable side effect profile make medication attractive choice clinicians treating patients plaque psoriasis
study drug target identified using kegg database network analysis cytoscape software designed series novel benzimidazoles taken along reference standard flibanserin insilico modeling novel benzo imidazol substituted phenyl oxobutanamide analogs synthesized evaluated antidepressant activity reaction benzo imidazol oxobutanoic acid benzo imidazol oxobutanoyl chloride furnished novel benzo imidazol substituted phenyl oxobutanamide newly synthesized compounds characterized nmr mass spectral analysis antidepressant activities synthesized derivatives compared standard drug clomipramine dose level among derivatives tested compounds found potent activity depression high level activity shown compounds significantly reduced duration immobility time dose level
study objectives insomnia prevalent health complaint often remains untreated several interventions efficacious widely available study evaluated efficacy self help behavioral intervention insomnia design study used conditions self help treatment treatment control assessments pretreatment posttreatment month follow mixed factorial design setting study part larger epidemiologic study conducted randomly selected sample adults province quebec canada participants one hundred ninety two adults women men mean age years insomnia selected larger community based epidemiologic sample randomly assigned self help treatment treatment control interventions self help intervention included educational booklets mailed weekly participants providing information insomnia healthy sleep practices behavioral sleep scheduling cognitive strategies measurements results participants completed sleep diaries questionnaires pretreatment posttreatment month follow significant modest improvements obtained subjective sleep parameters treatment control participants treated participants averaged nightly gains minutes sleep reduction minutes wakefulness corresponding increase sleep efficiency improvements also obtained measures insomnia severity insomnia severity index sleep quality pittsburgh sleep quality index changes maintained follow conclusions self help behavioral intervention effective alleviating broad range insomnia symptomatology community sample self help may promising approach make effective intervention widely available
borderline personality disorder bpd demonstrated reliable valid construct young people adolescents young adults borderline mood related psychopathology become clinically apparent puberty young adulthood frequently occur reinforce one another difficult differentiate clinically gordian knot overlapping clinical features common risk factors precursors bpd mood disorders complicates clinical assessment prevention treatment regardless whether individual crosses arbitrary diagnostic threshold considerable proportion young people borderline mood related psychopathology develop significant persistent functional vocational interpersonal impairment disability critical risk developmental period clear need early intervention spurious diagnostic certainty risks stigma misapplication diagnostic labels inappropriate treatment unfavorable outcomes article aims integrate early intervention bpd mood disorders clinical context developmental phenomenological change evolution clinical staging similar disease staging general medicine presented pragmatic heuristic trans diagnostic framework guide prevention intervention acknowledges early stages disorders disentangled sufficiently allow disorder specific preventive measures early interventions clinical staging defines individual location along continuum evolving temporal course disorder staging aids differentiation early milder clinical phenomena accompany illness progression chronicity suggests application appropriate proportionate intervention strategies
glucocorticoid receptor present virtually every human cell type representing nuclear receptor superfamily several different isoforms essentially acting ligand dependent transcription factors regulating glucocorticoid responsive gene expression positive negative manner although natural ligand glucocorticoid receptor glucocorticoids represent multiple ligands xenobiotics ubiquitous environment bind also capable activating repressing gene expression thereby modulating cell tissue specific downstream effects multitude ways include responses inflammatory allergic metabolic neoplastic autoimmune processes many xenobiotics inadequately metabolized xenobiotic metabolizing enzymes wholly eliminated could deleterious toxic effects potentially lethal consequences review examines genomic non genomic actions natural synthetic body handling xenobiotic compounds reviewing presently known interactions many commonly encountered less well known associated xenobiotics promiscuity crosstalk signaling pathways discussed alongside novel roles include mood disorder addiction knowledge interactions xenobiotics increasingly relevant considering aging populations related prevalence neoplastic disease together growing concerns around human exposure mixtures chemicals environment furthermore escalating rates obesity type diabetes autoimmune allergy addiction mood disorder related pathologies require novel targeted interventions appears promising pharmacological candidate elsevier inc rights reserved
research exploring parents experiences offspring autism spectrum disorder asd currently underrepresents fathers study aimed develop understanding experience fathers view facilitating improved support eight fathers participated semi structured interviews exploring experiences fathering children asd fathers described experiences path towards acceptance independence integration offspring key goals fathers saw advocates fighting obstructive services access appropriate care value placed formal informal support varied although need personalised support emphasised enabling fathers see experiences journey whilst engaging important topics independence integration may improve experience
osteoporosis major skeletal disease low bone mineral density leads increased risk bone fracture salubrinal synthetic chemical inhibits dephosphorylation eukaryotic translation initiation factor alpha eif alpha response endoplasmic reticulum stress understand possible linkage osteoporosis stress employed unloading mouse model examined effects salubrinal pathogenesis disuse osteoporosis results presented several lines evidence osteoclastogenesis development osteoporosis associated stress salubrinal suppressed unloading induced bone loss compared age matched control unloaded mice reduced trabecular bone area total area well number osteoblasts increased osteoclasts number trabecular bone surface time dependent way unloading induced disuse osteoporosis significantly increased expression bip elf alpha atf short term within tail suspension time dependent decreased hud hud furthermore significant correlation stress differentiation osteoblasts osteoclasts observed administration salubrinal suppressed unloading induced decrease bone mineral density mature osteoclast formation salubrinal also increased colony forming unit fibroblasts colony forming unit osteoblasts reduced formation mature osteoclasts suppressed migration adhesion increased expression bip elf alpha atf electron microscopy showed rough endoplasmic reticulum expansion decreased number ribosomes membrane observed osteoblast unloading mice abnormal expansion significantly improved salubrinal treatment tunel assay together ccaat enhancer binding protein homologous protein chop expression indicated stress induced osteoblast apoptosis rescued salubrinal collectively results support notion stress plays key role pathogenesis disuse osteoporosis salubrinal attenuates unloading induced bone loss altering proliferation differentiation osteoblasts osteoclasts via elf alpha signaling elsevier inc rights reserved
muff homolog mth nudix phosphohydrolase enzyme participates process repairing dna damage hydrolyzing oxidized deoxy ribonucleoside triphosphate cancer cells regarded potential target anticancer therapy order seek promising inhibitor mth structured based pharmacophore qsar pharmacophore hypotheses combine admet analysis lipinski rule five used screening public molecules libraries asinex ibscreen natural molecular docking studies performed screened hits via various docking programs glide gold glide five molecules three scaffolds picked potential inhibitors mth eventually molecular dynamics simulation implemented potential inhibitors rmsd root mean square deviation values used illustrate bind stability potential molecules mth therefore five hits may considered promising mth inhibitors studies elsevier rights reserved
stretching commonly used process manufacture forgings good quality paper stretching process cylinder forging materials properties materials engineering investigated finite element method metal flow law cylinder stretching process studied based simulation analysis effect tool geometry like flat shaped anvils strain stress distribution state forging reasonable tool geometry stretching shaped anvil
sufficient conditions derived global asymptotic synchronization system identical nonlinear electrical circuits coupled linear time invariant lti electrical networks particular conditions derive apply settings nonlinear circuits composed parallel combination passive lti circuit elements nonlinear voltage dependent current source finite gain collection circuits coupled either uniform homogeneous lti electrical networks uniform electrical networks identical per unit length impedances homogeneous electrical networks characterized effective impedance two terminals others open circuited synchronization networks guaranteed ensuring stability equivalent coordinate transformed differential system emphasizes signal differences applicability synchronization conditions broad class networks follows leveraging recent results structural spectral properties kron reduction model reduction procedure isolates interactions nonlinear circuits network validity analytical results demonstrated simulations networks coupled chua circuits
objectivesresidence based primary care provides homebound frail patients care plan individually tailored manage multiple chronic conditions functional limitations using variety resources examine visit volume medicare payments residence based health care provided nurse practitioners nps medicare fee service environment compare residential visits internists family physicians compare geographical service area full time house call nps versus nps make nursing facility visits major portion work designan observational study using secondary data settingmedicare provider utilization payment data participantsmedicare beneficiaries measurementsmedicare payments home domiciliary care visits number residence based medical visits provider volume geographical distribution full time house call providers resultsabout nps performed million home domiciliary care visits accounting residential visits medicare fee service beneficiaries total nps individually made residential visits defined full time house call provider among full time house call providers including physicians nps common provider type substantial variations geographic distribution full time house call nps internists family physicians full time service area larger family physicians internists nursing home residents far likely receive visits homebound persons receiving home visits conclusionnps largest type provider delivering residence based care nps provide care largest geographical service area however vast majority frail americans likely receive care nursing facility versus home
inevitable railway construction avoid crossing series large water area sometimes large span railway bridges must considered various differences high speed railway bridges ordinary railway bridges stiffness durability integrity smoothness dynamic effect maintenance also differences design methods design construction channel railway lines becoming imperative rapid progress china railway engineering choosing railway suspension bridge design engineering background steel truss suspension bridge span analyzed steel truss superior performance good ventilation torsional mechanics advantages widely used long span bridge process design follows firstly accessing relevant norms determine size structure paper secondly model bridge structure built using software midas calculate internal force according determined forces check stress calculation part rod cross section certain change finally according relevant regulations check main cable sling pylon stiffening girder joints
early detection fungal infection citrus fruit one major problems postharvest phase automation task still challenge citrus industry study potential application hyperspectral imaging combines conventional imaging spectroscopy simultaneously acquire spatial spectral information object evaluated automatic detection early symptoms decay caused penicillium digitatum fungus citrus fruit hyperspectral images sound decayed navel oranges acquired wavelength range principal component analysis pca applied dataset comparing average spectra decayed sound tissue reduce dimensionality data observe ability visible near infrared vis nir hyper spectra discriminate data two classes mean normalization step applied prior pca reduce effect sample curvature spectral profiles case observed sound decayed spectra separable along resultant first principal component axis four wavelength images centered selected characteristic wavelength images analyzing weight coefficients order develop fast classification method establishing line multispectral imaging system subsequently combination image obtained multiplying characteristic weight coefficients corresponding mean normalized characteristic wavelength images orange sample calculated determination decayed fruits based obtained multispectral combination image technique intensity slicing one pseudo color image processing methods used transform combination image visual classification image would enhance contrast sound decayed classes finally image segmentation algorithm detection decayed fruit developed based pseudo color image coupled simple thresholding method investigated naval orange samples including sound fruits infected fruits total success rate training set test set false negatives respectively indicating proposed multispectral algorithm capable detecting decay caused penicillium digitatum naval orange fruit using four key wavelength images results study could used development non destructive monitoring system rapid detection decayed citrus processing line idea behind proposed algorithm extended detect non visible damages fruit slight bruise chilling injury apples published elsevier
remarkable progress made developing psychosocial interventions eating disorders mental disorders two priorities providing treatment consist addressing research practice gap treatment gap research practice gap pertains dissemination evidence based treatments controlled settings routine clinical care closing gap known effective treatment actually provided patients receive care crucial improving mental health care particularly conditions eating disorders treatment gap pertains extending treatments ways reach large number people need clinical care currently receive nothing currently united states worldwide vast majority individuals need mental health services eating disorders mental health problems receive treatment article discusses approaches required better ensure people receiving treatment obtain high quality evidence based care using strategies train trainer web centered training best buy interventions electronic support tools higher level support policy higher proportion currently underserved receive treatment using strategies task shifting disruptive innovations including treatment delivery via telemedicine internet mobile apps
effects violent video game exposure youth aggression remain issue significant controversy debate yet clear whether violent video games uniquely contribute long term youth aggression whether relationship better explained third variables aggressive personality family environment current study examines influence violent video game exposure delinquency bullying behavior seventh eighth grade students variables parental involvement trait aggression stress participation extracurricular activities family peer support also considered results indicated delinquent bullying behavior predicted child trait aggression stress level violent video game exposure found predictive delinquency bullying level parental involvement results question commonly held belief violent video games related youth delinquency bullying
background chd chromodomain helicase dna binding protein codes member chd family atp dependent chromatin remodeling factors one commonly mutated genes autism spectrum disorders asd identified exome sequencing studies loss function mutations gene also found schizophrenia intellectual disabilities influence cancer cell proliferation previously reported rna seq analysis carried neural progenitor cells npcs monolayer neurons derived induced pluripotent stem ips cells heterozygous chd knockout alleles generated using crisprcas gene editing significant number asd candidate genes among differentially expressed comparison heterozygous lines chd isogenic controls chd including bipolar disorder candidate gene tcf markedly upregulated chd neuronal cells methods current study rna seq carried chd isogenic control chd vertical bar vertical bar cerebral organoids dimensional structures derived ips cells model developing human telencephalon results tcf expression significantly upregulated pathway analysis carried differentially expressed genes degs revealed enrichment genes involved neurogenesis neuronal differentiation forebrain development wnt beta catenin signaling axonal guidance similar previous study npcs monolayer neurons also significant overlap chd degs found transcriptome analysis carried another group using cerebral organoids derived family idiopathic asd remarkably top deg respective studies non coding rna dlx markedly upregulated studies dlx regulates expression members dlx distal less homeobox gene family dlx also upregulated studies dlx genes code transcription factors play key role gabaergic interneuron differentiation significant overlap also found transcriptome study carried another group using ips cell derived neurons patients condition characterized dysregulated wnt beta catenin signaling subgroup affected individuals conclusions overall findings show distinct asd candidate genes converge common molecular targets important consideration developing novel therapeutics genetically heterogeneous complex traits
study examined production inferential false memories complex pictorial stimuli implications affective content alzheimer disease group patients group healthy older adults studied sequence pictures depicting stories included positive negative neutral consequences unseen action completed old new picture recognition test number causal errors higher healthy older adults compared patients affective content attenuated effect causal errors increased patients stories included affective positive negative outcomes addition negative content produced larger number errors positive content across groups data confirms although memory processing poorer sensitive affective content accordingly nature affective false memory errors suggest need consider use affective information development new cognitive training procedures
paper presents design performance details chevrolet volt electric propulsion system propulsion system two machines one machine operating mostly motor machine operating mostly generator machines volt electric drive system permanent magnet synchronous machine types magnets buried inside rotor motor distributed windings however opposed conventional stranded winding chevrolet volt motor bar wound construction improve motor performance particularly low medium speed range higher speed skin proximity effects stator bars lead increased stator winding losses addressed design bar wound construction also excellent thermal performance steady state transient conditions necessary full electric vehicle driving generator uses concentrated windings concentrated winding construction good slot fill short end turn length features resulted good performance intended operational region enabler machine packaging inside transmission machines exhibit excellent efficiency exceptionally smooth quiet operation machine design construction details well measured thermal electromagnetic acoustic noise performances presented paper
antimicrobial resistance pathogenic gram negative bacteria one pressing challenges field infectious diseases one key areas unmet medical need identified antibacterial resistance leadership group arlg mission gram negative committee advance knowledge challenging infections implement studies improve patient outcomes studies fallen primarily broad categories prospective cohort studies interventional trials among observational studies crackle consortium resistance carbapenems klebsiella pneumoniae enterobacteriaceae contributed seminal multicenter data describing risk factors clinical outcomes carbapenem resistant enterobacteriaceae cre sentinel hospitals building success crackle expand network hospitals across united states colombia similar protocols proposed include acinetobacter baumannii pseudomonas aeruginosa snap pop studies addition crest study carbapenem resistant enterobacteriaceae solid organ transplant patients provided pivotal data extended spectrum beta lactamase esbl producing enterobacteriaceae cre carriage among solid organ transplant recipients inform management vulnerable patient population two clinical trials define novel ways using existing antibiotic fosfomycin treat esbl producing enterobacteriaceae one completed enrollment late protocol development determine clinical efficacy fosfomycin step oral therapy treat complicated urinary tract infections additional clinical studies trials using immunotherapeutic newly approved agents also planning stage main goals generating actionable data inform clinical decision making facilitate development new treatment options highly resistant gram negative bacterial infections
segmentation considered central part image processing system due high influence posterior image analysis recent years segmentation magnetic resonance images attracted attention scientific community objective assisting diagnosis different brain diseases several techniques thresholding represents one popular methods image segmentation currently extensive amount contributions proposed literature thresholding values obtained optimizing relevant criteria cross entropy however approaches computationally expensive since conduct exhaustive search strategy obtaining optimal thresholding values paper presents general method image segmentation estimate thresholding values proposed approach uses recently published evolutionary method called crow search algorithm csa based behavior flocks crows different optimization techniques used segmentation proposes csa presents better performance avoiding critical flaws premature convergence sub optimal solutions limited exploration exploitation balance search strategy although proposed method used generic segmentation algorithm characteristics allow obtaining excellent results automatic segmentation complex images circumstances approach evaluated using two sets benchmark images first set composed general images commonly used image processing literature second set corresponds brain images experimental results statistically validated demonstrate proposed technique obtains better results terms quality consistency elsevier ltd rights reserved
evidence type personality predict impaired quality life health status various chronic conditions evidence conflicting whether type associated increased healthcare services study reported healthcare utilization people living hiv plwh type personality study investigated impact type personality healthcare utilization sample chinese plwh examined physical emotional symptoms possible mechanisms healthcare utilization cross sectional study plwh rural china participants completed survey physical symptoms emotional symptoms healthcare utilization type personality plwh type personality reported physical emotional symptoms healthcare utilization patients without personality among plwh type personality physical symptoms direct effect healthcare utilization emotional symptoms significantly mediate association however among plwh without type personality emotional symptoms significantly mediated effects physical symptoms healthcare utilization plwh type personality reported healthcare utilization attributed high physical symptoms rather emotional symptoms findings suggest plwh type personality might bothered intensified emotional symptoms might severe associated physical symptoms healthcare utilization new prospective studies focus pattern healthcare utilization among patients type personality intensified physical emotional symptoms
series elastic actuator sea promising actuation method force control applications intelligently interacts environments sea characterized spring placed load actuator electric motor cases since spring plays role transducer position spring deflection force able control output force torque precisely utilizing typical position control methods however force control performance sea considered limitations due elasticity thus inferior rigid actuators terms bandwidth paper proposes force control performance sea improved exploiting dynamic model sea end sea modeled analyzed utilizing two mass dynamic model well known widely accepted model flexible system disturbance observer feedforward controller introduced model based control algorithms sea achieve high precision force control addition high bandwidth force control proposed controller address robust stability performance model parameter variance exogenous disturbances analytic quantitative assessment proposed force control system dynamic characteristics sea various control algorithms analyzed experimental results provided actual sea system paper
study used satellite imagery conduct statistical study ocean vortex train induced kuroshio current leeward side green island taiwan spatial scale characteristics ocean vortex train analyzed using image datasets five different high resolution satellites including optical imagery satellite pour observation terre formosat satellites synthetic aperture radar imagery european remote sensing satellite advanced land observing satellite sentinel satellite altimetry data moored acoustic doppler current profiler adcp used calculate velocity kuroshio current adcp data suggest velocity increases western side vortex train formed leeward side green island data moderate resolution imaging spectroradiometer modis showed sea surface temperature recirculation water degrees colder chlorophyll concentration two times higher surrounding waters phenomena suggested upwelling mixing processes island mass effect wind forcing pronounced effect characteristics vortex train high resolution satellite images indicate averaged aspect ratio vortex train dimensionless width southerly winds compared respectively northerly winds elsevier inc rights reserved
act wait concept recently developed type controller receiving growing interest promising features respect control systems feedback delay although advantages widely discussed verified experimentally detailed analysis nonlinear behavior type controller still missing paper apply act wait controller digital position control single degree freedom system analysis shows linear stability post bifurcation behavior system comparing system regular proportional differential controller act wait controller performed investigation confirms advantages act wait controller already known literature regarding enlargement stable region possibility achieving deadbeat control also presence delay hand shows drawbacks controller related post bifurcation behavior presents unbounded motions robustness stability appears limited
robotic writing challenging task involves complicated kinematic control algorithms image processing work paper alternatively proposes robot calligraphy system firstly applies human arm gestures establish font database chinese character elementary strokes english letters uses created database human gestures write chinese characters english words three dimensional motion sensing input device deployed capture human arm trajectories used build font database train classifier ensemble types human gesture used writing english letters types gesture used generate elementary strokes writing chinese characters using font database robot calligraphy system acquires basic writing ability write simple strokes letters robot develop write complex chinese characters english words following human body movements classifier ensemble used identify gesture implemented using feature selection techniques harmony search algorithm thereby achieving better classification performance experimental evaluations carried demonstrate feasibility performance proposed method following motion trajectories human right arm end effector robot successfully write english words chinese characters correspond arm trajectories
aims assess implications low testosterone cardiovascular risk factors metabolic syndrome mes clinical outcomes chinese men type diabetes methods prospective cohort study carried university hospital involving consecutive cohort chinese men median disease duration years followed years clinical characteristics frequency mes serum total testosterone clinical events analyzed multivariate logistic regression performed examine independent association low testosterone mes adjustment confounding covariates cox proportional hazards regression analysis used derive hazard ratio clinical outcomes results men low testosterone cardiovascular renal disease mes normal testosterone adjusted odds ratio low testosterone mes confidence interval median follow years hazard ratio low testosterone incident nonprostate cancer multivariate cox regression model hrs attenuated remained significant adjustment mes renal parameters conclusions chinese men low testosterone high prevalence cardiovascular disease mes high incidence non prostate cancer author published elsevier ireland ltd
background gonadectomy one common procedures performed dogs united states neutering shown reduce risk diseases although recent reports suggest increased prevalence structural disorders neoplasias relation neuter status autoimmune diseases explored study evaluated prevalence risk atopic dermatitis atop autoimmune hemolytic anemia aiha canine myasthenia gravis cmg colitis col hypoadrenocorticism add hypothyroidism hypo immune mediated polyarthritis impa immune mediated thrombocytopenia itp inflammatory bowel disease ibd lupus erythematosus lup pemphigus complex pemc intact females intact males neutered females neutered males pyometra pyo evaluated control condition results patient records william pritchard veterinary medical teaching hospital university california davis analyzed order determine risk immune mediated disease relative neuter status dogs neutered dogs significantly greater risk atop aiha add hypo itp ibd intact dogs neutered females greater risk neutered males aiha add neutered females males significantly greater risk lup intact females pyometra greater risk intact females conclusions data underscore importance sex steroids immune function emphasizing role hormones tissue self recognition neutering critically important population control reduction reproductive disorders offers convenience owners despite advantages analyses present study suggest neutering associated increased risk certain autoimmune disorders underscore need owners consult veterinary practitioner prior neutering evaluate possible benefits risks associated procedure
release water storage compartments transpiration stream important functional mechanism provides buffering sudden fluctuations water potential ability tissues release water per change water potential referred hydraulic capacitance assumed associated anatomy storage tissues however information specific anatomical parameters determine capacitance limited study measured sapwood capacitance terminal branches roots five temperate tree species fagus sylvatica picea abies quercus robur robinia pseudoacacia tilia cordata mill capacitance calculated separately water released mainly capillary open vessels tracheids fibres intercellular spaces cracks elastic storage compartments living parenchyma cells corresponding two distinct phases moisture release curve found generally higher roots branches times higher sapwood density ratio dead living xylem cells closely correlated addition magnitude strongly correlated fibre tracheid lumen area whereas highly dependent thickness axial parenchyma cell walls results indicate water released capillary compartments predominates water released elastic storage branches roots suggesting limited importance parenchyma cells water storage juvenile xylem temperate tree species contrary intact organs water released open conduits small wood samples significantly increased relatively high water potentials linking anatomical parameters hydraulic capacitance tissue contributes better understanding water release mechanisms implications plant hydraulics
background despite evidence poor adherence guideline directed statin therapy gdst following acute coronary syndrome acs little information published pharmacist led statin pilot programs secondary prevention objective sought evaluate impact pharmacist intervention gdst acs hospitalization methods historical control group consisting acs hospitalizations retrospectively identified prospective data patients captured months group primary outcome gdst defined according clinical guidelines evaluated qualifying patients secondary outcomes included number interventions use logistic regression investigate relationship acs subtype statin dose results admission gdst ordered group discharge group higher rate gdst relative among patients exclusion contraindications patients required accounting increase gdst statin dose selection differ acs subtype odds ratio conclusion significantly increase gdst increased compliance rates measured primarily driven higher baseline adherence guideline incorporation time
subspace learning methods feature selection methods often used removing irrelative features high dimensional data studies shown feature selection methods interpretation ability subspace learning methods output stable performance paper proposes new unsupervised feature selection integrating subspace learning method locality preserving projection lpp new feature selection method sparse feature level self representation method aim simultaneously receiving stable performance interpretation ability different traditional sample level self representation sample represented samples popularly used machine learning computer vision paper propose represent feature relevant features conduct feature selection via devising feature level self representation loss function plus norm regularization term add graph regularization term lpp resulting feature selection model simultaneously conduct feature selection subspace learning rationale lpp regularization term lpp preserves original distribution data removing irrelative features finally conducted experiments uci data sets real data sets experimental results showed proposed approach outperformed comparison algorithms elsevier rights reserved
present scalable computing framework solution stochastic multiobjective optimization problems proposed framework uses nested conditional value risk hcvar metric find compromise solutions among conflicting random objectives prove associated ncvar minimization problem cast standard stochastic programming problem expected value linking constraints also show problems implemented modular compact manner using plasm julia based structured modeling framework solved efficiently using pips nlp parallel nonlinear solver apply framework chp design study seek find compromise solutions trade cost water emissions face uncertainty electricity water demands elsevier ltd rights reserved
green building shown great advantage promoting economic efficiency however also exposed problems developing process among matter industrial chain stability vital one article employing theory biocenosis differential stability analyses composition green building industrial chain gbic symbiosis system divides types firm symbiosis basis study eco industrial chain logistic model enterprises growth described different symbiosis relationship analyzed stability
current development trends regarding mobile electrical generator sets egss indicate enhancement efficiency sought means operate driving engine either diesel gasoline continuously optimum speed engine generator dynamics sudden load change low load high load remains challenge regard dynamic behavior analysis presented proves introduction energy storage element egs variable engine speed concept eliminates drawback paper addresses identification dynamic behavior variable speed egs systems problems encountered sudden increase load power voltage drops
objective programmed death receptor negative regulator cell activation polymorphism gene pdcd previously shown associated several autoimmune inflammatory disorders including systemic lupus erythematosus multiple sclerosis examined first time association another inflammatory disease strong immune component ige mediated bronchial asthma severity biochemical markers total serum ige methods genotyped pcr rflp analysis using two different populations caucasian russian individuals asian buryat individuals results found significant association polymorphism ige mediated bronchial asthma total serum ige level russian population combined genotype correlated risk developing allergic bronchial asthma lower concentrations total serum ige compared wild type genotype however polymorphic buryat population conclusions polymorphism gene pdcd may contribute development allergic asthma russians buryats results could helpful better understanding effect polymorphism development diseases strong immune components
design cable supported bridge long span challenging due sensitivity dynamic excitation aerodynamic instability caused fluttering severely affect safe operation application indicial function flutter analysis time domain applied great belt east bridge completed erection stage nonlinear least square method used extract aerodynamic indicial parameters flutter analysis time domain geometric nonlinearity considered nonlinear dynamic analysis results showed good agreement wind tunnel test validity indicial function well important role geometrically nonlinear analysis deck erection
objectives two cluster solutions subtyping alcohol dependence investigated indian male population subtypes compared various personality traits childhood externalizing disorders also compared respect single nucleotide polymorphisms snp various candidate genes materials methods clinic based study conducted among patients patients assessed ssaga comorbid antisocial personality disorder aspd childhood conduct disorder oppositional defiant disorder odd attention deficit hyperactivity disorder adhd assessment personality traits indian adaptation sensation seeking scale sss barratt impulsiveness scale administered snp genotyping done using taqmann assay real time polymerase chain reaction results among two cluster model able produce maximum degree cohesion among disorders cluster separateness cluster one without aspd quality cluster analysis reduced odd adhd included model along aspd thus index population two distinct clusters one aspd externalizing cluster cluster without aspd nonexternalizing cluster cluster externalizing cluster significantly higher score impulsiveness sss cluster also significantly associated childhood adhd odd genotype frequencies candidate genes found nonsignificantly distributed among two groups conclusion study conferred cross cultural validation known alcoholism subtypes
paper develops compares several optimization approaches version planning release problem problem new challenging scholars practitioners fully addressed literature version releases part wide spread phenomenon mobile phones operating systems windows digital printers well known examples however version release found many product development fields software products games hardware versions screens communication equipment etc fields automotive field version release well established became annual routine optimization formulation developed total value version release policy throughout relevant time horizon novel formulation elements release features release dates value release derived combination features included specific released version version release dates developed several search techniques solving strongly hard problem compared results multiple particle swarm optimization mpso genetic algorithm simulated annealing two forms greedy heuristics comprehensive computational experiment performed study shows mpso outperform methods moreover medium scale problems better suits highly resource constrained cases mpso performs best large scale problems disregarding resource scarcity research may major reference point future research version release problem elsevier rights reserved
compound structure permanent magnet cspm motor used electrical continuously variable transmission cvt hybrid electric vehicle hev make internal combustion engine ice independent road loads run high efficiency area improve fuel economy reduce emissions paper studies magnetic coupling new type cspm motor used hevs firstly analysis parameter matching cspm hev receive dynamic properties design parameters cspm motor ths toyota hybrid system toyota prius next establish equivalent magnetic circuit model overall secondary model considering tangential radial flux distribution outer rotor cspm motor based two models explore internal magnetic coupling rule cspm motor finally finite element method analysis ansoft used analyze magnetic field distribution cspm motor different operation modes result finite element method analysis internal magnetic decoupling scheme put forward laying theoretical foundation application cspm motor hevs
wwii industrialized agriculture selected modern varieties triticum turgidum spp durum spp aestivum durum wheat common wheat based higher yields technological characteristics nowadays use whole ancient grains pseudo cereals considered nutritionally important ancient grains positive effects entirely known fragmentation scientific knowledge also related fact ancient grains homogeneous category kamut trademark indicates specific ancient variety grain triticum turgidum ssp turanicum commonly khorasan wheat guarantees certain attributes making studies sufficiently comparable work studies kamut khorasan wheat systematically reviewed evidencing different aspects supporting benefits although possible establish whether ancient grains share positive characteristics total part review provides evidences supporting consumption ancient grains
major advances memory forensics past decade allow investigators efficiently detect analyze many types sophisticated kernel level malware operating systems vendors routinely enforcing driver signing integrating strategies protecting kernel data patch guard userland attacks becoming attractive malware authors evidenced notorious crisis malware therefore turn attention improving memory forensics techniques analysis malware userland paper focus new methods detecting userland malware written objective mac paper illustrates objective provides rich set apis malware use manipulate steal application data perform malicious activities novel memory forensics techniques deeply examine state objective runtime inside targeted processes identifying number suspicious activities keystroke logging pointer swizzling examine techniques memory samples infected malware found targeted attacks authors published elsevier ltd
ross cheit book witch hunt narrative highlights difficulties prosecuting child sexual abuse drawing examples single case alex examine ways false acquittals sexual abuse likely occur first prosecutors tend question children ways undermine productivity credibility second prosecutors difficulty explaining juries dynamics sexual abuse disclosure making children acquiescence abuse failure disclose abuse first occurs incredible third attorneys undermine children credibility pushing provide difficult estimate temporal numerical information post script alex case illustrates costs wrongful acquittals
background many years conventional double contrast enteroclysis suggested technique choice evaluation small intestine computed tomography performed oral intravenous contrast material proven track record depicting bowel wall mesenteric abnormalities enteroclysis developed overcome individual deficiencies conventional enteroclysis combine advantages barium enteroclysis conventional abdominal examinations one technique present study longitudinal study evaluate role multi detector row helical computed tomographic enteroclysis depiction small bowel diseases patients aim study prospectively evaluate role multi detector row helical computed tomographic mdct enteroclysis depiction small bowel diseases materials methods study group enteroclysis done clinically suspected cases small bowel diseases referred department radiodiagnosis yenepoya medical college mangalore october september results patients underwent successful enteroclysis positive findings obtained patients negative findings obtained patients among patients enteroclysis allowed detection small bowel masses patients including adenocarcinoma gastrointestinal stromal tumour lymphoma enteroclysis demonstrated metastatic lymph nodes cases small bowel abnormalities patients including patients crohn disease patients small bowel tuberculosis images demonstrated site cause small bowel obstruction cases areas stenosis cases mural extramural inflammatory changes conclusion enteroclysis fast well tolerated reliable imaging modality depiction small bowel diseases technique provides adequate small bowel distension majority patients addition enteroclysis allows detection extraluminal disease provides information relative entire abdomen obtained small bowel follow endoscopy
heterogeneous ceramics made cordierite mullite alumina prepared sintering non standard raw materials containing corundum talc alpha quartz feldspar kaolinite mullite small amounts calcite cristobalite glass phases green specimens prepared pva assisted dry pressing sintered within temperature range degrees different dwelling times effects sintering schedule crystalline phase assemblage thermomechanical properties investigated sintered ceramics exhibited low coefficients thermal expansion cte degrees high flexural strength mpa high young modulus gpa specimens sintered degrees exhibited best thermal shock resistance delta similar degrees thermal expansion coefficients thermal shock resistance studied using schapery model modelling results implying occurrence non negligible mechanical interactions phases bulk dielectric properties characterized room high temperature degrees revealed noticeable effects sintering schedule dielectric constant dielectric loss factor similar stable dielectric properties failure electrode material thermomechanical properties coupled desirable dielectric properties make materials suitable high density integrated circuitry high temperature low dielectric materials engineering elsevier ltd techna group rights reserved
research audience interest violent media content extended include individuals appreciation certain types violent portrayals meaningful valuable reflection reality sample german adults aged watched movie trailers varied pretest ratings gore meaningfulness equivalent suspense hypothesized perceived levels gore meaningfulness interacted predict individuals reported likelihood watching full movie negative influence gore viewing likelihood compensated high levels meaningfulness findings suggest addition motivations suspense types violent even gory content might sought opportunity meaning making
background purpose atrial fibrillation significant carotid artery stenosis cas often coexist patients acute stroke whether cas affects stroke recurrence rate anticoagulated patients largely unknown effect concomitant cas short long term prognosis stroke patients evaluated methods multicentre retrospective fibstroke registry included patients ischaemic stroke transient ischaemic attack tia sub study patients ischaemic stroke tia significant cas cas group patients without cas non cas group identified median follow time index event interquartile range years long term stroke recurrence rate day mortality cha vasc score risk factors use intensity anticoagulation assessed results recurrence rate ischaemic stroke events per follow years significantly higher cas patients compared non cas group despite similar anticoagulation antithrombotic therapy cas patients higher mean cha vasc scores non cas patients however multivariate analysis cas shown independent risk factor stroke recurrence hazard ratio confidence interval day cause mortality significantly higher cas patients cas independent risk factor also day mortality odds ratio confidence interval conclusions patients concomitant cas independent risk factor long term stroke recurrence day mortality
background children asthma hay fever food allergy may several factors increase risk speech disorder including allergic inflammation add adhd sleep disturbance however studies examined relationship asthma allergic disease speech disorder sought determine whether asthma hay fever food allergy associated speech disorder children whether disease severity sleep disturbance add adhd modified associations methods analyzed cross sectional data children aged years population based studies including national health interview survey national survey children health results multivariate models controlling age demographic factors healthcare utilization history eczema lifetime history asthma odds ratio confidence interval one year history hay fever food allergy associated increased odds speech disorder children current past asthma increased risk speech disorder one study assessed caregiver reported asthma severity mild moderate asthma associated increased odds speech disorder however severe asthma associated highest odds speech disorder conclusion childhood asthma hay fever food allergy associated increased risk speech disorder future prospective studies needed characterize associations
bioidentical recombinant human epidermal growth factor rhegf available concentrations purity suitable therapeutic use long time stable formulations beneficial effects several skin pathologies lesions reported traumatic surgical wound healing laser induced wounds abnormal scars keloids radiation chemotherapy induced dermatitis post inflammatory hyperpigmentation skin aging damage repairing also may considered treatment several oropharingeal high gastroesophageal tract mucosa diseases mouth sores pharyngeal fistulas ulcers several corneal conjunctive mucosa lesions rhegf shown important side collateral effects humans laboratory experimentation animals showing optimal tolerability safety continuous use months compounding gives advantages versatility individualization personalization molecular stability safety effectiveness ideal conditions showing good tissue penetration intact skin skin lesions expose lower planes surface rhegf compounds considered prevention treatment diverse skin mucosa diseases conditions compounding preparations elsevier espana rights reserved
objective sought understand experiences patients lung cancer see attitudes varied demographic factors methods administered question survey phone online among patients lung cancer factor analysis used identify two groups questions conceptual relationship high cronbach alphas stigma satisfaction care used multivariable analysis identify predictors self blame factors stigma satisfaction care results patients satisfied quality care treatment choices feel enough public support research lung cancer predictors lower satisfaction care never smoker lack college education living rural location refusing report income knowing sure stage self blame modest multivariable analysis predictors self blame believing smoking cause lung cancer younger age male sex living suburban location knowing sure stage cancer reported stigma low predictor stigma married despite low scores personal experience stigma patients reported high degree stigmatization lung cancer general smoking significant predictor personal stigma conclusion despite satisfaction treatment care lung cancer patients feel society stigmatizes general population patients smoke likely report personally experienced stigma
best knowledge present first hardware implementation isogeny based cryptography available literature particularly present first implementation supersingular isogeny diffie hellman sidh key exchange features quantum resistance optimize design speed creating high throughput multiplier unit taking advantage parallelization arithmetic minimizing pipeline stalls optimal scheduling consequently results also faster software libraries running affine sidh even intel haswell processors implementation bit quantum security bit classical security generate ephemeral public keys million cycles alice million cycles bob generate shared secret additional million cycles alice million cycles bob virtex results approximately times faster known software implementations running bit sidh results observations show isogeny based schemes implemented high efficiency reconfigurable hardware
work describe high level matlab simulink model sensor system vapor trace detection different molecules air using array differently functionalized capacitive sensors extremely sensitive integrated electronic detection system model includes adsorption desorption process differently modified sensors high level model low noise analog signal processing electronics proposed model makes possible study interactions selectivity sensitivity sensor system efficiently forms basis design different modules sensor system including pattern recognition algorithms way design process shortened demonstrator measurements show promising detection limit ppt tnt band close simulation results
introductionpre operative vitamin deficiency markedly prevalent prospective bariatric surgery patients bariatric surgery leads significant weight loss exacerbate prolong vitamin deficiency systematically reviewed literature assess whether secondary hyperparathyroidism maintained medium long term patients following roux gastric bypass methodsa comprehensive literature search conducted medline embase scopus web science dare cochrane library hta database search terms used bariatric surgery gastric bypass hyperparathyroidism resultsfourteen studies included subjects parathyroid hormone levels rose gradually mean pre operative level pmol pmol pmol pmol years years beyond years respectively vitamin levels slowly fell mean follow intervals years beyond respectively conclusionit appears hyperparathyroidism persists year follow gastric bypass despite patients supplemented calcium vitamin
last decade number available cores increased heterogeneity grew work ask question whether design current operating systems oses still appropriate trends continue lead abundantly available heterogeneous cores whether forces fundamental rethinking systems designed argue hiding heterogeneity behind common hardware interface unifies large extent control coordination cores accelerators isolating network chip rather processor features like privileged mode memory management unit allows running untrusted code arbitrary cores providing services via protocols network chip instead via system calls makes accessible arbitrary types cores well summary turns accelerators first class citizens enables single convenient programming environment cores without need trust application paper introduce network chip level isolation present design microkernel based common hardware interface evaluate performance prototype comparison linux bit surprising without using accelerators outperforms linux application level benchmarks factor five
investigated regulatory activity human adipose derived mesenchymal stromal cells mscs towards immune cells cohort rheumatoid arthritis patients apparently healthy controls cultured mscs lymphocyte subsets regulatory cells tregs levels pro anti inflammatory markers tumor necrosis factor alpha tnf alpha interferon gamma ifni gamma interleukin estimated serum culture supernatants study revealed two fold increase proportion tregs increased level foxp mscs altered cell cell treg cytokine production anti inflammatory immune response mscs inhibited cell mediated tnif alpha secretion upregulated suppressed production autoantibodies citrullinated protein antigens produced cells data offer insight interactions allogeneic mscs immune cells elucidate dose dependent modulation mscs elsevier inc rights reserved
atopic dermatitis stress create vicious cycle stress exacerbates atopic symptoms atopic disease elicits stress anxiety targeting multiple pathways including stress allergic inflammation therefore important treating study investigated remedial value polygala tenuifolia willd ptw treating immobilization imo stress exacerbated atopy like skin dermatitis underlying mechanism trimellitic anhydride tma applied dorsal skin sensitization subsequently ears eliciting cell dependent contact hypersensitivity mice underwent imo stress ptw administration latter days ear exposure period tma respectively elicit vitro degranulation human mast cell line hmc substance corticotrophin releasing factor crf sequentially added interval ptw extract added min crf treatment imo stress exacerbated tma induced scratching behavior increased blood corticosterone levels two fold treatment ptw significantly restored imo stress exacerbated scratching behavior indicators skin inflammation water content lymph node weights serum histamine immunoglobulin lge levels furthermore also reversed tma stimulated expression tumor necrosis factor tnf alpha interleukin mrnas ear tissues ptw significantly inhibited crf stimulated degranulation hmc cells subsequent tryptase secretion protein kinase pka activity ptw also selectively inhibited mitogen activated protein kinase mapk phosphorylation crf treated hmc cells ptw significantly inhibited hmc cell degranulation alleviated imo stress exacerbated atopic dermatitis symptoms modulating pka mapk signaling pathway
gene encoding serotonin receptor hydroxytraptamine htrc implicated behavioral phenotypes number species previous studies mutation chicken htrc gene found associated feather condition thereby suggesting relationship gene receiving feather pecking activity present study analyzed chicken htrc gene genomic make expression level dongxiang blue shelled layer significant association single nucleotide polymorphism snp feather condition confirmed chinese local layer enhanced htrc gene expression fold associated high feather damage indicated right cerebrum might critical region htrc participate regulation receiving feather pecking behavior
objectives chronic migraine prevalent devastating disorder limited therapeutic options study explored efficacy flunarizine prophylaxis compared topiramate methods conducted prospective randomized open label blinded endpoint trial patients randomized flunarizine topiramate treatment primary outcomes assessed reductions total numbers headache days migraine days weeks treatment secondary outcomes reductions numbers days acute abortive medication intake acute abortive medication tablets taken responder rate results sixty two subjects randomized group patients treated flunarizine showed significant reductions numbers total headache days migraine days compared treated topiramate patients treated flunarizine also showed significant reductions numbers days acute abortive medication intake acute abortive medication tablets taken higher responder rate terms total headache days migraine days compared topiramate treated patients flunarizine generally well tolerated safety profile comparable topiramate conclusions results suggest week study flunarizine effective topiramate prophylaxis
quality products competitive advantage small software development organizations usage software systems engineering standards amongst small organizations extremely low key factor literature explaining lack quality standards adoption perception small small organizations standards developed large multi national companies small small organizations mind iso iec standard unique amongst software systems engineering standards working group iso iec jtc mandated develop new standard approached industry conduct needs assessment gather actual requirements new standard part standards development process paper presents historical perspective behind development iso iec systems software engineering standard constituent components including rationale behind development innovative design implementation guides assist small companies adopting standards paper present overview various parts iso iec family briefly present plans future evolution series standards
libcoopt open source matlab code library provides general convenient tool approximately solve combinatorial optimization problems set partial permutation matrices frequently encountered computer vision bioinformatics social analysis etc use library user needs give objective function gradient function associated problem two typical problems subgraph matching problem quadratic assignment problem employed illustrate use library also flexibility different types problems
paper presents analytical study parsec benchmark suite order examine auto vectorization potential emerging workloads icc gcc compilers investigating auto vectorization potential analyzed amount vectorized non vectorized loops number vector instructions application found time consuming loops applications vectorized modified applications profiled shown applying modifications considerable effect amount vectorized loops number instructions reduced expect limited size simd width current processors result addition applying algorithmic methods loop unrolling splitting large loops definition data structures replacing function calls loops function bodies removing control flows loops possible cases help compilers auto vectorization increasing simd width vector extension cpus important issue order improve speed performance elsevier rights reserved
dual stator spoke array vernier permanent magnet dssa vpm machines proposed previous papers proven high torque density high power factor however design procedure dssa vpm machines well established little design experience followed makes dssa vpm machine design quite difficult paper presents detailed dssa vpm machine design procedure including decision design parameter initial values analytical sizing equation geometric size relationship order get reasonable design parameter initial values reduce number design iteration loop influence key parameters rotor stator pole combination slot opening magnet thickness etc performances analyzed based finite element algorithm fea paper analysis results regarded design experience selection process initial values analytical sizing equation geometric relationship formulas derived used obtain optimize size data dssa vpm machines little time consumption combination analytical fea methods makes design procedure time effective reliable finally design procedure validated experiments dssa vpm prototype
advances functional brain imaging improved search potential endophenotypic markers schizophrenia employed independent component analysis ica dynamic causal modeling dcm resting state fmri sample schizophrenia patients first degree relatives control subjects analysis ica derived networks revealed increased functional connectivity left frontoparietal network fpn left temporal parietal regions schizophrenia patients first degree relatives shared hyperconnectivity particular supramarginal gyrus smg dcm analysis employed explore underlying effective connectivity results showed increased inhibitory connections left angular gyrus schizophrenia patients nodes left fpn particular left smg relatives also showed pattern increased inhibitory connections left furthermore patient group showed increased excitatory connectivity left fusiform gyrus left smg connection negatively correlated inhibitory afferents left negative symptom score panss scale left frontoparietotemporal dysfunction schizophrenia previously associated range abnormalities including formal thought disorder working memory dysfunction sensory hallucinations analysis uncovered new potential endophenotypic markers schizophrenia shed light organization left fpn patients first degree relatives wiley periodicals inc
increase intelligent devices ubiquitous computing spreading scopes people life smart home industrial environments include automation control devices save energy perform tasks assist give comfort order satisfy specific preferences paper focuses proposal software reference architecture development smart applications deployment smart environments motivation reference architecture benefits also explained proposal considers three main processes software architecture applications perception reasoning acting paper centres attention definition perception process provides example implementation subsequent validation proposal software presented implements perception process smart environment standard office retrieving data real world storing reasoning acting processes objectives solution include provision comfort users saving energy lighting verification also shown developments proposal produce major benefits within software life cycle elsevier rights reserved
complex real cycle zero dimensional model simulation stationary dynamic load conditions turbocharged diesel engine driving synchronous electrical generator presented model generally applicable forms turbocharged diesel engines computer program based model caried results simulation model application diesel generating set dynamic working conditions ohmic inductive loads acceptance loading start presented
objectivea review treatment options menstrual migraine backgroundmigraine affects approximate million people subset female migraineurs migraines mainly associated menstruation menstrual migraine divided pure menstrually related migraine pure attacks occur menstruation prevalence menstrually related migraine prevalence occurs menstruation well rest cycle usually without aura severe longer lasting resistant treatment due effects ovarian hormones specifically estrogen treatment divided acute short term prophylaxis daily prevention best studied acute treatments triptans short term prophylaxis triptans non triptans combinations used preventive medications may used daily prevent many anti epileptic medications used migraine prevention affect efficacy oral contraceptives hormonal treatments caution indicated used methodspubmed scopus cochrane embase searched treatments resultsmany randomized placebo controlled prospective studies evaluated efficacy sumatriptan rizatriptan naratriptan zolmitriptan almotriptan reviewing numerous studies statistically significant results rizatriptan best overall evidence acute treatment ranging pain free responses hours sumatriptan rizatriptan shown similar efficacies terms hour pain freedom rizatriptan showed sustained pain relief hours efficacy sustained pain freedom hours efficacy short term prevention four randomized controlled trials frovatriptan taken twice daily one trial zolmitriptan taken three times daily two studies naratriptan taken twice daily showed statistically significant results among studies non triptans short term prevention magnesium estrogen naproxen sodium dihydroergotamine statistically significant results many antiepileptic medications taken prevention cause enzyme induction affecting oral contraceptives ocs hormonal treatments different degrees topiramate least effect ocs doses day lamotrigine noticeably decreases oral contraceptive levels however evidence preventive medication strong conclusionmm difficult treat acute treatments rizatriptan best overall evidence short term prevention frovatriptan zolmitriptan naratriptan well magnesium estrogen naproxen sodium dihydroergotamine may useful
objective evaluated whether association adult attention deficit hyperactivity disorder adhd seasonal affective disorder sad mediated circadian rhythm method data persons netherlands study depression anxiety nesda used two groups compared clinically significant adhd symptoms adhd symptoms sleep parameters sleep onset offset times mid sleep sleep duration munich chronotype questionnaire identified prevalence probable sad subsyndromal sad using seasonal pattern assessment questionnaire spaq clinically significant adhd symptoms identified using score conners adult adhd rating scale results prevalence probable sad estimated adhd group adhd group probable sad adhd group adhd group regression analyses showed consistently significant associations adhd symptoms probable sad even adjustment current depression anxiety age sex education use antidepressants benzodiazepines late self reported sleep onset important mediator significant relationship adhd symptoms probable sad even correction confounders total model effects conclusion seasonal circadian rhythm disturbances significantly associated adhd symptoms delayed sleep onset time adhd may explain increase sad symptoms treating patients sad possible adhd delayed sleep onset time may reduce symptom severity complex patients elsevier ltd rights reserved
residual stresses deteriorate strength materials affecting quality industrial products removal reduction residual stresses essential procedure successful engineering component development effective convenient methods necessary detection evaluation residual stresses paper hole drilling method chosen identification quantitative determination residual stresses specimens two groups different laser welding speed conditions min min lap joints welded sts sheet two different speeds investigated along welding line two locations middle end location heat affected zone haz identification haz carried taking hardness values weld centerline raw material based experimental results analysis found higher welding speed reduces residual stresses also end location found higher residual stress area compared middle location due convective boundary condition residual stresses decrease depth increases top surface due lower heat input depth increments
paper report electrosynthesized cadmium sulfide cds thin films electron beam irradiation solar cell application deposited irradiated cds thin films characterized structural surface morphological electrical properties xrd sem photoelectrochemical cell measurement confirmed optical photoelectrochemical properties improved irradiation treatment work useful surface tailoring providing novel approach improve photoelectrochemical properties nanostructured cds thin films promising applications nano system devices convert solar energy maximum efficiency fill factor found kgy respectively
prototype home management system hms controlled mobile device developed project teams computing education academy cea fairfield university integrating arduino appinventor cea established fairfield university expose high school students key computing concepts basic computer programming hands activities motivate students enter post secondary education career opportunities computing cea class modules include scratch appinventor circuit design arduino final team project developing home management system guidance graduate assistants faculty fairfield university home management system consists several modules remotely control lamp central light air conditioner door lock electronic devices room using mobile app team created one module controls displays current status component user interface home screen system mobile device various sensors receivers motors relays used integrated arduino gsm shield details implementation future direction discussed
paper introduces new electric machine front end accessory drive fead hybrid electric vehicles hevs novelty electric machine lies ability perform multitasking besides independent motor independent generator operation like electric machine proposed machine able run motor generator simultaneously dual winding electric machine forms core part proposed system windings electric machine concentrated type electrical magnetic isolation maintained allows simultaneous motoring generating operation single housing electric machine design considerations proposed electric machine outlined paper comparison proposed conventional approaches made highlight potential benefits new approach thermal analyses performed show suitability limits multitasked electric machine hev applications overall performance proposed machine presented experimental results elsevier rights reserved
emotion dysregulation core feature borderline personality disorder bpd far many studies tested consequences implementation certain emotion regulation strategies investigations choices bpd thus aim study investigate habitual choices self report questionnaires experimentally testing preference select distraction reappraisal facing different emotional intensities high low contents borderline specific unspecific negative patients bpd compared clinical controls patients major depression healthy control group additionally heart rate responses continuously assessed main results revealed patient groups showed maladaptive self reported choice profiles compared found however differences groups choice distraction reappraisal behavioral level responses bpd within group analyses revealed positive correlation symptom severity preference distraction high intensity borderline specific stimuli findings provide preliminary evidence choices bpd show robustness choice effect patients affective disorders elsevier ireland ltd rights reserved
although importance cellular forces wide range embryogenesis disease processes widely recognized measuring forces challenging especially three dimensions introduce cellfit force inference technique allows tension maps three dimensional cellular systems estimated image stacks like predecessors video force microscopy cellfit cell mechanics technique assumes boundary specific interfacial tensions primary drivers constructs force balance equations based triple junction dihedral angles technique involves image processing segmenting cells grouping cell outlines calculation dihedral planes averaging along three dimensional tjs matrix equation assembly solution equations tend strongly overdetermined allowing indistinct tjs ignored solution error estimates determined application clean noisy synthetic data generated using surface evolver gave tension errors analyses eight cell murine embryos gave estimated errors smaller uncertainty companion aspiration experiments possible areas application include morphogenesis cancer metastasis tissue engineering article part themed issue systems morphodynamics understanding development tissue hardware
treatment systemic immunomodulatory agents indicated patients moderate severe plaque psoriasis psoriatic arthritis patients surgery may confer increased risk infectious surgical complications conducted literature review examine studies addressing use methotrexate cyclosporine targeted immunomodulatory agents tumor necrosis factor alfa inhibitors interleukin inhibitors inhibitors patients undergoing surgery examined total studies majority retrospective studies patients rheumatoid arthritis inflammatory bowel disease one study patients psoriasis psoriatic arthritis reviewed procedures find elevated risk postoperative complications tumor necrosis factor alfa inhibitors even major surgeries based level iii evidence infliximab adalimumab etanercept methotrexate cyclosporine safely continued low risk operations patients psoriasis psoriatic arthritis moderate high risk surgeries case case approach taken based patient individual risk factors comorbidities
objectives episodes psychotic agitation frequent patients dual diagnosis patients concomitant psychiatric substance use disorders rapid intervention needed treat agitation mild stage prevent escalation aggressive behavior inhaled loxapine demonstrated rapidly improve symptoms mild moderate agitation adults psychiatric disorders schizophrenia bipolar disorder data patients dual diagnosis scarce methods study retrospective review data case series patients dual diagnosis attended symptoms agitation emergency room outpatient clinic hospitalization center spain patients received inhaled loxapine treating agitation episodes results data patients dual diagnosis reviewed patients psychiatric disorders schizophrenia bipolar disorder drug induced psychotic disorder posttraumatic stress borderline antisocial personality disorder depression anxiety along variety substance use disorders alcohol cocaine cannabis amphetamines hypnotics antianxiety drugs caffeine street drugs overall dose inhaled loxapine needed calm patient acute episode agitation conclusions inhaled loxapine rapid effective well accepted dual pathology patients presenting acute agitation emergency setting inhaled loxapine facilitated patient cooperation adequate management disease
cellulose aerogels low density high mechanical strength low thermal conductivity promising candidates environmentally friendly heat insulating materials application cellulose aerogels heat insulators building domestic appliances however hampered highly flammable characteristics work flame retardant cellulose aerogels fabricated waste cotton fabrics situ synthesis magnesium hydroxide nanoparticles nps cellulose gel nanostructures followed freeze drying results demonstrated three dimensionally nanoporous cellulose gel prepared naoh urea solution could serve scaffold template nonagglomerated growth nps prepared hybridized cellulose aerogels showed excellent flame retardancy could extinguish within meanwhile thermal conductivity composite aerogel increased moderately specific surface area decreased slightly indicated excellent heat insulating performance cellulose aerogel maintained concepts process simple biomass wastes sustainable readily available low cost present approach suitable industrial scale production great potential future green building materials
acetyl cholinesterase ache inhibitors donepezil rivastigmine galantamine approved fda first line drugs treat cognitive symptoms alzheimer disease beneficial effects attributed ability elevate endogenous acetylcholine ach muscarinic receptor brain however side effects nausea vomiting dizziness insomnia loss appetite altered heart rate related non specific activation muscarinic subtypes various tissues logical therefore develop agonists receptor selectivity unfortunately limited due high degree orthosteric site homology among receptor subtypes contrast allosteric sites unique therefore allow selective targeting using positive allosteric modulators pams pams receptors devoid agonist activity however bound enhance binding affinity orthosteric ligand ach major limitation pams bioavailability brain current hypothesis propose surface modified nano lipid drug conjugates ldc nps pams receptors improve bioavailability brain administered ache inhibitors expected increase efficacy reduce therapeutic dose side effects elsevier ltd rights reserved
past researches gas leakage clearance seal studied mainly analytical model numerical simulations using cfd method based classical fluid mechanics theory conditions steady laminar flow incompressible constant temperature constant viscosity relative sliding inner outer wall however widely known cfd theory may applicable micro size flow paper molecular mechanism gas leak clearance seal investigated molecular dynamics simulations johnson potential model used atomic interactions uff universal force field potential model used atomic interactions gap thickness varied pressure difference ends gap mpa mpa simulation results show leakage rate proportional pressure difference gap thickness process leakage sticky layers formed gap walls number density atoms sticky layer much larger central region density gas flow leakage much smaller gas reservoir leakage mechanism mainly due diffusion motions atoms sticky layers although moving speed sticky layers slow leakage flow rate simulation quite consistent analytical calculation elsevier ltd rights reserved
november general election subsequent voting electoral college resulted selection donald trump president united states incoming administration ran campaign indicated desire substantial change health policy including repeal affordable care act aca president trump said little directly hiv programs policies campaign positions repeal aca would clearly substantially impact lives persons living hiv editorial highlight important hiv related goals must recommit underscore several key points evidence based advocacy important revisit time especially change administration
polymer blending used one step surface modification technique alter wettability electrospun mats work blends hydrophobic thermoplastic elastomer sees hydrophilic peo amphiphilic peo ppo peo prepared resulting surface properties investigated low surface energy ppo block drove segregation amphiphilic polymer hydrophilization achieved aqueous medium surprisingly surface segregation continued room temperature weeks processing expected equilibrium blend morphology discussed explain ageing results addition effect different matrices mobility amphiphilic molecules analyzed comparing segregation peo ppo peo rubbery sebs rigid low glass transition temperature sebs increased free volume fraction room temperature facilitated segregation
purpose present interim findings epilepsy birth control registry ebcr regarding impact various contraceptive methods seizures stratified antiepileptic drug aed type methods observational study reports interim findings first subjects results significantly greater relative risks seizure increase decrease hormonal contraception non hormonal contraception nhc rates experiences associated seizure increase greater nhc rates experiences associated seizure decrease greater nhc differences reflect biological effects reporting bias finding greater seizure increase hormonal patch combined oral contraceptive perhaps related delivery substantially higher concentrations hormones greater seizure decrease depomedroxyprogesterone known reduce seizure frequency used dosages produce amenorrhea support biological effects aed categories showed significantly higher frequencies reports seizure increase combined nhc seizure increase higher valproate aed category significant differences among aeds seizure decrease juncture study overall neiaeds favorable profile regard reports seizure increase decrease used conclusions interim ebcr findings suggest contraception category interactions contraception category aed category predictive factors changes seizure frequency wwe british epilepsy association published elsevier ltd rights reserved
background students educated schools autism spectrum disorder asd ever architects interior designers need consider environmental features may modified enhance academic social success autistic students school aim study explored existing empirical research impact noise children asd provides recommendations regarding design features contribute noise reduction methods procedures survey addressed impact architectural design elements autism related behavior developed teachers children asd distributed three schools outcomes results teachers found noise control important issue students autism many observed children using ear defenders terms managing issues related noise teachers agreed thick soundproof walls carpet classroom important issues children asd conclusions suggested future research address architectural considerations building acoustically friendly environment children autism identifying patterns problematic behaviors response acoustical features built environment classroom setting ways manage maladaptive behaviors acoustically unfriendly environments elsevier ltd rights reserved
latinos largest fastest growing ethnically diverse group united states latino children also among overweight obese ethnic groups children united states research last decade identified home environment key influence diet physical activity children summarize cross sectional longitudinal research identified factors within home environment latino families associated childhood obesity provide recommendations future research intervention development latino families decade review conducted studies identifying factors within home environments latino families associated childhood obesity examined five main factors identified across literature home environment factors associated childhood obesity latino children factors included parental influences parent feeding practices modeling screen time physical activity sedentary behavior socioeconomic status food security sleep duration current review identified several home environment factors may contribute disparities childhood obesity latino children results review focusing decreasing controlling parent feeding practices increasing parent modeling healthy behaviors child sleep duration used developing culturally specific interventions latino children
dalenberg argued convincing evidence supports longstanding trauma model posits early trauma plays key role genesis dissociation refutes fantasy model posits fantasy proneness suggestibility cognitive failures variables foster dissociation review evidence bearing dalenberg predictions find largely wanting empirical support contend authors repeat errors committed many previous proponents attributing central etiological role trauma absence sufficient evidence specifically dalenberg leap quickly correlational data causal conclusions adequately consider lack corroboration abuse many studies underestimate relation dissociation false memories nevertheless identify points agreement regarding potential moderators mediators dissociative symptoms family environment biological vulnerabilities hypothesis dissociative identity disorder disorder self understanding acknowledge trauma may play causal role dissociation role less central specific dalenberg contend finally although key assumption dissociative amnesia notion people encode traumatic experiences without able recall lacks strong empirical support accordingly conclude field abandon simple trauma dissociation model embrace multifactorial models accommodate diversity causes dissociation dissociative disorders
psoriasis inflammatory disease skin sometimes accompanied auto inflammatory arthritis called psoriatic arthritis psa psoriasis psa multifactorial diseases result complex interactions environmental genetic risk factors epigenetic marks labile chemical marks diverse functions form layer biological information sits interface genetics environment aberrant epigenetic regulation previously implicated rheumatological disorders purpose review summarize critically evaluate nascent literature epigenetics psoriasis psa systematic review yielded primary articles applying inclusion exclusion criteria data extracted using standardized template study quality assessed using methodological quality checklist studies reflect broad range epigenetic sub disciplines common dna methylation followed parent origin effect genomic imprinting expression activity epigenetic modifying enzymes histone modifications epidemiological studies demonstrating excessive paternal transmission provided earliest evidence epigenetic deregulation psoriatic disease however studies examined molecular mechanisms methylation studies evolved rapidly low resolution global targeted analyses known psoriatic disease susceptibility loci hla recent explosion epigenome wide association studies provided novel insights psoriasis pathogenesis mechanism action uvb methotrexate anti tnf therapies well molecular signatures psoriasis may clinical relevance finally recent studies pharmacological inhibitors epigenetic modifier enzymes demonstrate potential applicability novel treatment modalities psoriasis challenges epigenetics research psoriasis psa identified future perspectives discussed herein elsevier ltd rights reserved
human tauopathies alzheimer disease frontotemporal dementia parkinsonism linked chromosome ftdp pick disease etc group neurodegenerative diseases characterized abnormal hyperphosphorylation tau leads formation neurofibrillary tangles recapitulating several features human neurodegenerative disorders drosophila tauopathy model displays compromised lifespan locomotor function impairment brain vacuolization adult brain progressive age dependent demonstrate tissue specific downregulation drosophila homolog human myc proto oncogene dmyc suppresses tau mediated morphological functional deficits reducing abnormal tau hyperphosphorylation restoring heterochromatin loss studies show first time inherent chromatin remodeling ability myc proto oncogenes could exploited limit pathogenesis human neuronal tauopathies drosophila disease model interestingly recent reports successful uses anti cancer drugs alzheimer parkinson diseases clinical trials animal models strongly support findings proposed possibility
ullrich krueger brod groschupf using replication trait paradigm norton frost ariely suggest less information always equal greater liking first ground current debate larger historical debate social psychology regarding merits configural versus algebraic models person perception next review related research suggested information cases lead liking large body real world data friendships daters married couples employment celebrities politics suggests information often leads less liking provide additional replication less effect using slight variation trait list paradigm existing data suggest need integrative explorations familiarity leads contempt liking effect
antisocial behavior adolescence predicts problematic outcomes adulthood however researchers noted marked heterogeneity within broad group youth engaging destructive behaviors attempted identify distinct etiologies different trajectories symptoms present study evaluate prominent subtyping approaches age onset presence callous unemotional traits aggressive versus rule breaking symptoms examined overlap subtypes predictive validity diverse sample low income young men followed prospectively adolescence emerging adulthood found early starting uniquely high aggressive symptoms traits early starting aggression rule breaking measured adolescence predicted subsequent psychiatric outcomes early adulthood univariate models whereas traits predictive adolescent arrests later substance dependence diagnosis later traits finally accounting shared variance among predictor variables found aggressive symptoms explained unique variance predicting several later outcomes antisocial personality disorder subtyping approaches results discussed relation use existing subtyping approaches noting aggression age onset traits appear best predicting later negative outcome
district heating southern europe relevant energy sector improved terms efficiency monitoring metering systems without underrating investments cost heat losses poor technical conditions combined high operational costs seriously affect competitiveness paper analyses criticalities combined heat power chp plant coupled located central italy explores possible solutions improve efficiency profitability first chp plant described main features effects operation produced reduction supply water temperature criticalities highlighted lifetime put evidence chp oversizing low profitability present energy market order overcome criticalities introduction internal combustion engine high temperature heat pump thermal energy storage tank existing chp system analysed results show best option new cogeneration gas engine sized baseload thermal demand allowing improvement primary energy saving revenues configuration heat pump instead affects positively profitability energetic efficiency opposite obtained tes elsevier ltd rights reserved
good skin detector capable capturing skin tones different conditions important human machine interaction applications general situation skin detectors skin probability maps gaussian mixture models achieve acceptable skin segmentation results however false positive rate increases significantly skin tones shadow skin like background objects similar illumination paper propose novel skin feature learning algorithm based stacked autoencoders deep neural networks overcome problems encountered skin segmentation caused different ethnicities varying illumination conditions stacked autoencoders utilized learn discriminative representations skin area rgb color space hsv color space unlike traditional machine learning methods instead predicting pixel individually algorithm utilizes blocks learn representations detect skin areas algorithm exploits learning ability deep neural networks learn high level representations skin tones experiments test images show proposed algorithm achieves acceptable results several publicly available data sets reduce difficulty detecting skin pixels data sets ground truths data sets commonly focused foreground skin area detection skin detector also able detect background areas shown experiments
investigated whether negative affective states enhance encoding memory item specific information reducing false memories positive negative neutral moods induced participants completed deese roediger mcdermott drm false memory task list items presented unique spatial locations unique fonts serve measures item specific encoding negative mood conditions accurate memories item specific information also fewer false memories final experiment used manipulation drew attention distinctive information aided learning drm words also promoted item specific encoding condition promoted item specific encoding false memories reduced positive neutral mood conditions rate similar negative mood condition experiments demonstrated negative affective cues promote item specific processing reducing false memories people positive negative moods encode events differently creating different memories event
study presents novel islanding detection optimal load shedding scheme radial distribution systems integrated dispersed generation simple effective passive islanding detection method developed based phase space technique using probabilistic neural network based classifier system detects unintentional islanding state utilises optimal load shedding scheme prevent system collapse due load generation mismatch voltage instability encountered islanded part system optimal load shedding scheme developed based backtracking search algorithm extensive tests conducted digsilent power factory software matlab software ieee bus system four units considering several scenarios islanding condition utilised evaluate effectiveness proposed islanding detection method optimal load shedding scheme results showed proposed method effectively detect islanding events stabilise islanded part system minimum load curtailment
paper studies robust resource allocation algorithm design multiuser multiple input single output miso cognitive radio downlink communication network focus secondary system provides wireless unicast secure layered video information multiple single antenna secondary receivers resource allocation algorithm design formulated nonconvex optimization problem minimization total transmit power secondary transmitter proposed framework takes account quality service qos requirement regarding video communication secrecy secondary system imperfection channel state information csi potential eavesdroppers primary receivers secondary transmitter limit maximum tolerable received interference power primary receivers thereby proposed problem formulation exploits self protecting architecture layered transmission artificial noise generation ensure communication secrecy considered nonconvex optimization problem recast convex optimization problem via semidefinite programming sdp relaxation shown global optimal solution original problem constructed exploiting primal dual optimal solutions sdp relaxed problem addition two suboptimal resource allocation schemes proposed case solution dual problem unavailable constructing optimal solution simulation results demonstrate significant transmit power savings robustness csi imperfection proposed optimal suboptimal resource allocation algorithms employing layered transmission compared baseline schemes employing traditional single layer transmission
realm state trial courts child abuse neglect dependency proceedings unique dependency proceedings place courts position determining ultimate result overseeing ongoing actions state agency court proceedings continue twenty one years without culminating trial must revise rules appellate procedure protect review dependency decisions children families access justice deserve
many species insects agricultural pests cause economic losses also allergies humans subject study identify important antigens saw toothed grain beetle oryzaephilus surinamensis sera patients suburban population upper silesia southern poland tested presence ige antibodies antigens particular active life stages larvae pupae adults sexes collected proteins fractionated sds page identified western blot patient antibodies particular antigens identified using anti human anti ige monoclonal antibody conducted studies showed existence many protein fractions life stage give positive reactions ige antibodies largest number allergenic potential fractions shown females protein fractions pupae protein fractions smaller amount shown larvae protein fractions males protein fractions majority sera showed positive reactions protein fractions kda kda pupae obtained results may indicate existence many protein fractions allergenic properties also stressed life stages storage insect may provoke allergic reactions exposed subjects elsevier ltd rights reserved
live migration virtual machines vms useful resource management data centers cloud platforms precopy algorithm widely used memory migration however encountered write intensive workloads precopy straightforward iteration strategy become inefficient worse still hard tune performance existing parameters unless load characteristics known advance paper propose improved pre filter copy pfc algorithm main target reduce migration time bandwidth resource consumption precopy algorithm keeping downtime level designed novel data filter achieve goal round iteration forecasts pages subsequently dirtied filters send list meanwhile previously filtered pages reconsidered see added send list ensures downtime increased furthermore new parameter proposed improve adaptivity precopy algorithm experimental results show pfc algorithm significantly reduces migration time amount migrated data keeping downtime level
extend paper previous results concerning differential algebraic index hybrid models electrical electronic circuits specifically present comprehensive index characterization holds without passivity requirements contrast previous approaches applies nonlinear circuits composed uncoupled one port devices index conditions stated terms forest structure certain digraph minors depend specific tree chosen formulation hybrid equations additionally show include memristors hybrid circuit models direction extend index analysis circuits including active memristors recently used design nonlinear oscillators chaotic circuits also discuss extension results circuits controlled sources making framework interest analysis circuits transistors amplifiers multiterminal devices
every complex problem days require multicriteria decision making get desired solution numerous multi criteria decision making mcdm approaches evolved recent time accommodate various application areas recently explored alternative solve complex software engineering problems widely used approach analytic hierarchy process combines mathematics expert judgment analytic hierarchy process suffers problem imprecision subjectivity paper proposes use fuzzy ahp fahp instead traditional ahp method usage fahp helps decision makers make better choices relation tangible criteria intangible criteria paper provides clear guide fahp applied particularly software engineering area specific situations conclusion study would help motivate practitioners researchers use multi criteria decision making approaches area software engineering
force sensing control paramount importance robotic micromanipulation contact force regulator capable accurately applying mechanical stimuli live drosophila larva could greatly facilitate mechanobiology research drosophila may eventually lead novel discoveries mechanotransduction mechanisms neuronal circuitries paper present novel contact force control scheme implemented automated drosophila larvae micromanipulation system featuring switched fuzzy proportional differential controller noise insensitive extended high gain observer ehgo switched fuzzy control law inherits fast convergence fuzzy control overcomes drawbacks large overshoot steady state oscillation noise insensitive ehgo reliably estimate system modeling errors robust force measurement noises advantageous conventional high gain observers sensitive signal noises force control experiments show compared proportional integral differential pid controller new force control scheme significantly enhances system dynamic performance terms rising time overshoot oscillation developed robotic system force control scheme applied mechanical stimulation fluorescence imaging drosophila larvae identifying new mechanotransduction mechanisms
article examines challenges associated rainwater harvesting usage peri urban accra data collected heads household reveal rainwater harvesting potential supplement existing water sources peri urban accra however high investment costs rainwater harvesting facilities short term tenancy arrangements perception rainwater clean unique dry climate accra plains emerge key challenges limiting domestic use rainwater public education house owners invest rainwater harvesting facilities governmental support needed increase investment rainwater harvesting purification usage
study examined services provided one statewide warmline established assist parents caregivers children birth adolescence warmlines offer telephone based non crisis support individuals experiencing diverse issues include parenting questions concerns university alabama child development resources collaborated alabama state department child abuse neglect prevention institute parenting assistance line provide information support parents caregivers children age birth adolescence overall staff parenting assistance line responded calls years data reported secondary data analysis calls parenting assistance line june july study describes concerns callers relation ages children calling also evaluates perceptions helpfulness information support provided warmline found frequently calls involved parent support parental stress parents caregivers children infancy adolescence findings suggest telephone assistance lines offer viable choice parents caregivers seeking affordable accessible resources stressed responsibilities caring children adolescents seeking information related parenting issues study identified limitations research involving secondary data collected purposes research program administrators evaluators consider planning implementing services nature
life expectancy increased many countries result world population aging projections indicate proportion elderly decades increase significantly aging carries series physiological changes one imbalance hemostatic system thus levels activity various proteins involved coagulation factors natural anticoagulants fibrinolytic system altered hemostatic balance leans toward thrombosis also platelet activity suggests state abnormal activation selectin beta thromboglobulin platelet factor review systematically examine alterations hemostatic components occur aging therefore understanding hemostatic changes could contribute developing strategies proper management health old age elsevier ireland ltd rights reserved
aim research programme develop series methods solutions support decision making process foundry materials engineering specific problems discussed included selection methods data processing knowledge representation formalisms backed creation decision algorithms based contemporary achievements artificial intelligence tailored needs foundry industry metallurgy manufacturing process metal items associated many aspects affect quality end product process engineers responsible supervising planning production important feature among others diversified nature numerous aspects knowledge acquisition integration distributed sources information made available appropriate manner support improvement manufacturing process
atopic diseases known characterized helper skewed immunity however studies addressing immunity birth related development atopic diseases early childhood investigated children followed regularly clinic years birth cohort study associated cxc chemokine ligand cxcl cxcl associated chemokine ligand ccl ccl quantified cord blood multiplex luminex kits specific immunoglobulin antibodies food inhalant allergens measured months well years age cord blood ccl levels positively associated ige sensitization age whereas cord blood cxcl levels negatively associated mite sensitization age furthermore high cord blood ccl cxcl chemokine ratio significantly associated higher risk allergic sensitization age confidence interval however cord blood associated chemokines ratios associated atopic diseases different age study indicates skewed immunity birth may increase risk allergic sensitization allergic outcomes later life
background serotonin hydroxytryptamine key modulatory neurotransmitter mammalian central nervous system cns plays important role developmental signal several lines evidence associate altered signaling psychopathology humans particularly neurodevelopmental disorders autism spectrum disorders asd asd characterized persistent social communication deficits along stereotyped repetitive patterns behavior symptoms emerging early development methods employed mouse model devoid brain due lack gene encoding tryptophan hydroxylase tph initial rate limiting enzyme synthesis cns tph null mutant tph mice show normal prenatal development however display yet unknown reasons severe growth retardation first postnatal weeks investigated therefore whether tph mice display deficits isolation induced ultrasonic vocalizations usv pups early life isolation induced usv commonly studied behavioral measure assess developmental delays communication deficits rodent models asd particularly serve important communicative function coordinating mother pup interactions results tph mouse pups displayed clear deficit emission isolation induced usv compared heterozygous wildtype littermates exactly growth retardation onset including reduced call numbers deficits call clustering temporal organization conclusions ultrasonic communication impairment displayed tph mouse pups likely result deficient mother infant interaction presumably contributing growth retardation phenotype represents prominent feature relevant asd
purpose review paper reviews research substance use disorders suds among adults diabetes describes epidemiological data suds persons type diabetes overviews effects substance use diabetes outcomes discusses treatments suds patients diabetes recent findings rates current smoking range alcohol use disorders rates illicit suds population based studies using nationally representative samples smoking increases risk long term diabetes complications premature death alcohol illicit drug use also impact long termdiabetes complications impairing glucose homeostasis adversely influencing self management behaviors mixed evidence psychosocial smoking cessation interventions adults diabetes little alcohol illicit sud interventions limited data exist pharmacotherapies suds population recent study suggests varenicline safe effective treating smoking patients diabetes summary substance use understudied problem type diabetes addressing substance use holds potential improving outcomes additional large population based epidemiological studies type diabetes needed particularly alcohol illicit suds longitudinal studies conducted better understand time course diabetes onset outcomes relation suds randomized controlled trials needed assess safety efficacy promising psychosocial pharmacological interventions
research psychopathology identified psychological processes relevant across range diagnostic statistical manual dsm mental disorders efforts begun produce treatment principles protocols applied transdiagnostically however review recent work suggests great variability conceptions term transdiagnostic treatment development literature believe value arriving common understanding term transdiagnostic purpose current paper outline three principal ways term transdiagnostic currently used delineate treatment approaches fall three categories consider potential advantages disadvantages approach
new application geosynthetic tube offshore dike construction geosynthetic mattress horizontal dimension much greater vertical one makes stable sausage shaped geosynthetic tube however existing analytical numerical methods developed sausage shaped geosynthetic tube may applicable directly geosynthetic mattresses solution may converge paper closed form solution derived direct determination cross section geosynthetic mattress laboratory large scale model tests also carried verify proposed analytical method cross sections geosynthetic mattresses obtained closed form solutions agreed well data obtained model tests tensile forces measured model tests rather scattered showed consistent thread closed form solutions elsevier ltd rights reserved
using narrative approach explored acculturation gaps parent child relationships conflict intergenerational conflict ethnocultural identity conflict sample immigrant arab canadian emerging adults findings revealed perceived acculturation gaps occurred intergenerational conflict theme ethnocultural identity conflict theme furthermore parent emerging adult relationship observed play role occurrence perceived acculturation gaps conflict specifically participants described strong parent emerging adult relationships minimizing occurrence perceived acculturation gaps intergenerational conflict theme well perceived acculturation gaps ethnocultural identity conflict theme hand participants described weak parent emerging adult relationships exacerbating occurrence perceived acculturation gaps intergenerational conflict theme well perceived acculturation gaps ethnocultural identity conflict theme presented analyses using thick rich data extracts participants
decades research demonstrated physical stress stimulates bone remodeling affects bone structure function complex mechanotransduction mechanisms recent research laid ground hypothesis mental stress also influences bone biology eventually leading osteoporosis increased bone fracture risk effects likely exerted modulation hypothalamic pituitaryadrenal axis activity resulting altered release growth hormones glucocorticoids cytokines demonstrated human animal studies furthermore molecular cross talk mental thought exist either synergistic preventative effects bone disease progression depending characteristics applied stressor mini review explain emerging concept important player bone adaptation potential cross talk summarizing current state knowledge highlighting newly evolving notions intergenerational transmission stress epigenetic modifications affecting bone proposing new research directions
purpose reviewmore point care poc diagnostic tests becoming available hiv diagnosis treatment resource limited settings novel technologies potential foster decentralized hiv care treatment benefit clinical laboratories hiv clinics hiv infected patients continue many business technological operational challenges limit product development regulatory approval limits products available required operational cost effectiveness studies delays policy adoption implementation recent findingsalthough rapid hiv diagnostic test widely successful pathways poc cell count hiv viral load assay analyzers challenging describe significant hurdles product development approval implementation include business case technical development clinical impact integrating laboratory clinical networks summarythe objective review highlight obstacles developing implementing appropriate strategies poc hiv testing assays improve clinical services hiv infected patients resource limited settings
study designed investigate developmental changes true false memories detect links among middle childhood participants italian children years males divided two age groups hearing story children provided free recall true false retrieved information measured children repeatedly asked true misleading questions story cued recall interrogative suggestibility measured finally children recalled story assess post event misinformation effect suggested information individual differences fluid intelligence working memory executive functions also assessed investigate relationships true false memories typical age effects found memory recall interrogative suggestibility interesting links among true spontaneous suggested false memories found finally analyses reveal existence relationship suggestibility cognitive functioning
background porto alegre brazilian state capital second highest incidence tuberculosis highest proportion people infected human immunodeficiency virus hiv among patients hepatitis virus hcv infection increases risk anti drug induced hepatotoxicity may result discontinuation therapy objectives aim study estimate prevalence hcv hiv group patients newly diagnosed active public reference hospital porto alegre compare demographic behavioural clinical characteristics patients relation hcv infection status methods one hundred thirty eight patients tested anti hcv antibody hcv rna anti hiv antibody markers hcv rna real time polymerase chain reaction pcr positive samples submitted reverse transcription pcr amplification non coding region hcv genome sequenced genotypes hcv isolates determined findings anti hcv antibody hcv rna anti hiv antibodies detected confidence interval patients respectively hcv isolates belonged genotypes characteristics significantly frequent patients infected hcv among non white individuals alcoholics users illicit drugs imprisoned individuals history previous episode commonly infected hcv main conclusions hcv screening including detection anti hcv antibody hcv rna important improving management infected patients given increased risk developing treatment related hepatotoxicity
growing body evidence suggests amygdala central handling demands complex social life primates paper synthesize extant anatomical functional data rodents monkeys humans describe topography three partially distinct large scale brain networks anchored amygdala support unique functions effectively managing social interactions maintaining social relationships findings provide powerful componential framework parsing social behavior partially distinct neural underpinnings differ among healthy people disintegrate fail develop neuropsychiatric populations marked social impairment autism antisocial personality disorder frontotemporal dementia elsevier ltd rights reserved
background although benefits skin skin care ssc well documented literature practices clinical setting remain inconsistent although nurses reported knowledge ssc improved confusion still exists regarding safety appropriateness existing qualitative literature primarily focuses parents experiences yet crucial describe essence professional caregivers experiences enhance facilitation implementation ssc studies surrounding caregiver perspective ssc focused barriers impede implementation examined experience organizational perspective general group experiences rather individual personal experiences ssc purpose meta ethnography integrated findings several discrete studies salient interpretative perspective creating relevant understanding process ssc means enhancing facilitation implementation ssc hospitalized infants methods ethnographic meta synthesis qualitative literature completed results result synthesis caregivers experiences separated themes articulate phenomena juxtaposed original studies influence facilitation ssc parent infant dyad qualitative data analysis uncovered overarching themes varying thresholds getting started defining adequate resources navigating demands complexity infant balancing parental readiness infant needs implications practice ethnographic meta synthesis confirms nurses good intentions supporting ssc practices yet struggle meet competing demands daily practice implications research innovative practical translations ssc needed normalize ssc daily standard premature infants
maternal immune activation prenatal development including treatment viral rna mimic polyriboinosinic polyribocytidilic acid poly serves widely used animal model induce behavioral deficits reminiscent schizophrenia related disease report massive cytokine activation single dose poly prenatal period associated lasting working memory deficits adult offspring explore whether dysregulated gene expression cerebral cortex contributes cognitive dysfunction profiled cortical transcriptome addition mapped genome wide distribution trimethylated histone lysine hkme epigenetic mark sharply regulated end transcriptional units however deep sequencing based hkme mapping mrna profiling microarray reveal significant alterations mature cerebral cortex poly exposure embryonic days small set genes including suppressor cytokine signaling socs hkme sensitive activation cytokine signaling primary cultures fetal forebrain adult cortex saline poly exposed mice show significant differences limited set transcription start sites tss including disrupted schizophrenia disc schizophrenia risk gene often implicated gene environment interaction models showed altered hkme prenatal poly none differences survived correcting multiple comparisons conclude prenatal poly associated cognitive deficits later life without robust alterations epigenetic regulation gene expression cerebral cortex elsevier rights reserved
introduction sexual dysfunction particularly erectile dysfunction common men type diabetes occurring cases prevalence hypogonadism also high men diabetes low testosterone associated sexual dysfunction reduced response oral therapy aim study aimed determine effect testosterone replacement long acting testosterone undecanoate sexual function mood quality life placebo treatment period weeks followed weeks open label medication study conducted primary care population men type diabetes attending primary care physician routine visits methods male diabetic populations seven general practices screened routine diabetes visits detect symptomatic men total testosterone levels nmol less free testosterones pmol less two hundred eleven men screened double blind placebo controlled study conducted men type diabetes hypogonadism treated weeks either matching placebo followed week open label follow main outcome measures primary outcome measure international index erectile function iief used evaluate sexual dysfunction ageing male symptom ams hospital anxiety depression scale global efficacy question used secondary outcome measures assess mood self reported quality life results testosterone replacement therapy long acting improved domains sexual function weeks erectile function intercourse satisfaction sexual desire overall satisfaction orgasm benefit early weeks improvements ams score significant men without depression presence depression baseline associated marked reduction response sexual function psychological scores responses sexual function continued improve significantly months improvement score baseline small cohort men taking phosphodiesterase type inhibitors change double blind phase nine point improvement domain week open label treatment weeks patients active therapy placebo felt treatment improved health reaching open label therapy less obese older patients responded better testosterone therapy significant adverse events conclusion significantly improved domains iief patient reported quality life weeks significantly week open label extension improvement marked less obese patient without coexisting depression men type diabetes trials therapy may need given much longer months suggested current guidelines
paper investigates studies acceleration irregular regular algorithms via integrate graphic processing unit integrated gpu known accelerated processing unit apu fused die cpu discrete graphic processing unit gpu answering question potential apu applications iregular data structures trees knowing apu share power bandwidth resources cpu morever paper determine cases apu considered cheaper solution gpu cosmological body simulation two different implemntations used case study regular irregular algorithms results indicated gpu powerful apu conducted tests
paper addresses one major web end user software engineering weuse challenges namely verify validate software products built using life cycle enacted end user programmers end user development support tools implement engineering life cycle adapted needs end users end users programming knowledge training experience perform development tasks requiring creativity elsewhere published life cycle adapted challenge support wizard end user programmers follow life cycle develop rich internet applications ria meet specific end user requirements however end user programmers regard verification validation activities secondary unnecessary opportunistic programming tasks hence although solutions develop may satisfy specific requirements impossible guarantee quality reusability software either user developments future end user programmers challenge find means adopting verification validation workflow adding verification validation activities existing weuse life cycle involve users make substantial changes type work priorities paper set verification validation life cycle supported wizard walks user test case based component integration acceptance testing wizard well aligned weuse characteristic informality ambiguity opportunisticity users applying verification validation process manage find bugs errors would otherwise unable identify also receive instructions error correction assures composite applications better quality reliably reused also report user study users develop web software without wizard drive verification validation aim user study confirm applicability effectiveness wizard verification validation ria elsevier inc rights reserved
background fatigue common persistent complaint following traumatic brain injury tbi effective treatment well established objective current study aimed investigate efficacy weeks light therapy fatigue patients tbi methods undertook randomized placebo controlled study week min morning home based treatment short wavelength blue light therapy max lux photons compared yellow light therapy max lux photons containing less photons short wavelength range treatment control group per group patients tbi self reported fatigue sleep disturbance assessments fatigue secondary outcomes self reported daytime sleepiness depression sleep quality sustained attention conducted weeks baseline week midway end light therapy weeks weeks following cessation light therapy week results controlling age gender baseline depression treatment high intensity blue light therapy resulted reduced fatigue daytime sleepiness treatment phase evidence trend toward baseline levels weeks treatment cessation changes observed lower intensity yellow light therapy treatment control conditions also significant treatment effect observed self reported depression psychomotor vigilance performance conclusions blue light therapy appears effective alleviating fatigue daytime sleepiness following tbi may offer noninvasive safe nonpharmacological alternative current treatments
transportation inevitable poultry industry induce stress chicks varying degrees mild discomfort sometimes even death however research effects transport stress weight loss heart injury chicks lacking elucidate underlying mechanism transport stress induced effects chicks transported creatinine kinase activities ionic contents atpases activities transcription atpase associated subunits chick heart detected results showed transport stress increased weight loss activity disturbed ionic homeostasis inhibited atpase atpase atpase atpase atpase activities increased atp content downregulated gene expression levels atpase associated subunits heart conclusion transport stress disturbed ionic homeostasis via modulating ion transporting atpases transcriptions associated subunits ultimately induced weight loss heart injury chicks
pass networks prescribed group delay used analog signal processing equalization transmission channels state art methods synthesizing quasi arbitrary group delay functions using pass elements lack theoretical synthesis procedure guarantees minimum order networks present analytically based solution problem produces pass network response approximating required group delay within arbitrary minimax error first time method shown work physical realization second order pass elements guaranteed converge global optimum solution without choice seed values input allows synthesis pre defined networks described analytically numerically proposed method also demonstrated reducing delay variation practical system desired amount compared state art methods comparison examples
young children suspected abusive head trauma often receive skull radiographs evaluate fractures well computed tomography head assess intracranial injury using primary modality evaluate fracture intracranial injury could reduce exposure radiation without sacrificing performance evaluate sensitivity head reconstruction compared skull radiographs identify skull fractures children suspected abusive head trauma retrospective cross sectional study infants evaluated abusive head trauma via skull radiographs reconstruction reference standard skull radiography studies read pediatric radiologists neuroradiologists ten percent read second radiologist evaluate interobserver reliability one hundred seventy seven children female mean median age months included sixty two skull fractures radiography reconstruction sensitive confidence interval specific skull fracture significant difference plain radiographs scan results value kappa value radiologist readings cts skull radiographs reconstruction equivalent skull radiographs identifying skull fractures head indicated skull radiographs add little diagnostic value
recently electric network frequency enf natural signature embedded many audio recordings utilized criterion examine authenticity audio recordings enf based audio authentication system involves extraction enf signal questioned audio recording matching reference signal stored enf database establishes popular application audio timestamp verification paper explore another important application enf based audio tampering detection received less research attention specifically introduce absolute error map aem enf signals obtained testing audio recording database aem serves ensemble raw data associated enf matching process intensive analysis aem propose two algorithms jointly deal timestamp verification tampering detection including insertion deletion splicing attacks respectively first algorithm based exhaustive point search measurement second algorithm leverages image erosion technique achieve fast detection tampering type tampered region thus second algorithm sacrifices accuracy speed authentication mechanism system first determines testing data tampered outputs timestamp information tampering detected otherwise outputs tampering type tampered region demonstrate effectiveness proposed solution via synthetic practical examples practically deployed audio authentication system
model unsteady evolution turbulent buoyant plumes following temporal changes source conditions integral model derived radial integration governing equations expressing evolution mass axial momentum buoyancy plume non uniform radial profiles axial velocity density deficit plume explicitly captured shape factors integral equations commonly assumed top hat profiles lead shape factors equal unity resultant model unsteady plumes hyperbolic momentum shape factor determined radial profile mean axial velocity plume differs unity solutions model source conditions maintained constant values shown retain form well established steady plume solutions demonstrate linear stability analysis steady solutions inclusion momentum shape factor governing equations differs unity leads well posed integral model therefore model exhibit mathematical pathologies appear previously proposed unsteady integral models turbulent plumes stability threshold value shape factor also identified resulting range values amplitudes small perturbations steady solutions decay distance source hyperbolic character system equations allows formation discontinuities fields describing plume properties unsteady evolution compute numerical solutions illustrate transient development plume following abrupt change source conditions adjustment plume new source conditions occurs propagation pulse fluid plume dynamics pulse described similarity solution construction new similarity solution identify three regimes evolution transient pulse following adjustment source qualitatively differs
emotional dysregulation explored mediator relationship perceived father rejection young adult male female aggression among undergraduate college students emotional dysregulation assessed combined construct distinct components analyses revealed impulsivity mediated relationship perceived father rejection aggression males females nonacceptance emotions partially supported mediator perceived father rejection aggression relationship among males females results suggest although father child relationships may contribute variety emotion regulation difficulties impulsivity may play integral role development aggression researchers clinicians encouraged pay particular attention process impulsivity may influence aggression father rejected sons daughters additional attention nonacceptance emotions sons limitations future research recommendations discussed
modern embedded systems accommodate different applications functionalities substrate provide flexibility hardware level often resource redundant consequently power hungry therefore dedicated design frameworks required implement efficient runtime reconfigurable platforms frameworks challenge scenario need also offer application specific support power management work adopt dataflow specifications starting point feature power minimization coarse grained reconfigurable embedded systems proposed flow composed two subsequent steps characterization optimal topological system specification identification disjointed logic regions latter used implement clock power gating methodologies validity model based approach proved reconfigurable computing core multi functional coprocessor image processing applications results assessed targeting asic technology one
ambient intelligence ami paradigm applied healthcare sector promising solution develop software based systems capable supporting medical procedures activities carried close high regulated complex healthcare environment ami healthcare system ami may impact health life users doctors caregivers patients etc considered medical device mds thus subject pass cumbersome risk based regulatory process evaluates certifies system safety put market thus human centred risk analysis paramount importance establish safety level ami paper propose dynamic probabilistic risk assessment dpra approach ami allows quantitative assessment risk different hazard scenarios order support design development ami hss provide objective evidences needed regulatory process addition support risk based methodology define probabilistic risk model prm based extension markov decision process mdp capable taking account two main peculiarities ami hss context awareness personalisation preliminary results show feasibility approach capability model assess risk context aware hazard scenarios
aim study examine parenting desire intention experience among sample lesbian gay bisexual individuals portugal ages years approximately reported children majority stating biological kinship children primarily previous heterosexual relationships central focus current study includes participants without children average years younger children among group stated desire children stated intention children future multiple regression revealed young age involvement lesbian gay bisexual transgender events low religiosity significantly predicted parenting intention explore effects age parenting intention analysis variance conducted younger participants reported significantly stronger parenting intention differences detected age developmental group
objective examine possible association maternal request caesarean section two intrapsychic psychoanalytic personality variables object relations unconscious defences background maternal request growing phenomenon studies lacking regarding personality variables may associated methods cross sectional questionnaire conducted one delivery ward primigravida healthy women recruited requested delivered without obstetrical indication opted spontaneous vaginal delivery due missing data measures participants analysed group women completed fear childbirth foc questionnaire object relations scors unconscious defences dmm measures thematic apperception test tat well questionnaires assessing background variables multivariate analysis variance manova logistic hierarchical multiple regression performed results preliminary manova showed significant differences groups age foc use defence mechanism projection hence variables entered predictors maternal request logistic hierarchical multiple regression model model found good fit age foc projection defence found significant factors associated maternal request conclusion maternal request found strongly associated age foc except unconscious defence projection intrapsychic variables found associated maternal request possible implications discussed
strength properties materials static dynamic loading essential quantities characterizing mechanical behavior quantitative measurements static strengths achieved diamond anvil cell made using ray diffraction radial geometry samples non hydrostatic compression results several metals gpa show ratio yield strength shear modulus ranges increases weakly compression trends lower pressure epsilon consistent available data mbar strong ceramics sin tib achieve yield strengths large shear modulus pressures similar gpa strengths materials used pressure media quantitatively compared evaluated
backgroundhigh neonatal mortality india previously attributed low proportion institutional deliveries however significant rise proportion facility based births last decade achieved desired reduction neonatal mortality possibly result low skilled care facilities study evaluated effectiveness mobile nurse training knowledge based intervention nurses improve essential newborn specific delivery practices methodseighty health centers obstetric care facilities selected eight districts bihar intervention teams composed two trained nurses conducted week long workshop per month every health facility months independent evaluation team conducted baseline postintervention assessments every facility assessments included passive observation newborn specific delivery practices recording results preformatted checklist based tool resultsthe intervention associated significant increases odds four recommended practices placing newborn mother abdomen adjusted odds ratio aor wiping eyes sterile gauze aor skin skin care aor guidance initiation breastfeeding aor intervention also found positively associated summary score improvements newborn specific delivery practices one year intervention summary practice score remained higher baseline decline time conclusionsthe mobile nurse training intervention provides pathway improving adherence recommended newborn specific delivery practices among institutional birth attendants rural bihar
representation reasoning context information main research area ambient intelligence ami context modeling applications facing openness heterogeneity tackle problems argue usage semantic web technologies promising direction introduce consert approach context meta modeling offering consistent uniform means working domain knowledge well constraints meta properties thereof provide formalization model detail innovative implementation using techniques semantic web community ontology modeling sparql stepwise example modeling commonly encountered ami scenario showcases expressiveness approach finally architecture representation reasoning engine consert presented evaluated terms performance elsevier ltd rights reserved
aim retrospective study prospective data collection correlate congenital cytomegalovirus cmv infection autism spectrum disorder asd define prevalence seventy proven congenitally infected infants born referred centre cmv diagnosis follow consisted consolidated protocol allowing early evaluation autism considered four children year old two age diagnosed asd demonstrating fold higher prevalence general italian population protocol enabled make earliest diagnosis highlight role virus among causes autism may long term sequela congenital cmv
online discussion forums one ubiquitous kinds resources people learning computer programming however user interface hierarchy textual threads changed much past four decades argue generic forum interfaces cumbersome learning programming need domain specific visual discussion forum programming support argument empirical study forum threads introduction computer science programming using python popular edx mooc specifically investigated forum participants hampered text based format notably people often wanted discuss questions dynamic execution state happens hood computer runs code propose better forum learning programming visual domain specific integrating automatically generated visualizations execution state enabling inline annotations source code output
symmetric key cryptography resist potential post quantum attacks expected faraway advent quantum computing power hash based code based lattice based multivariate quadratic equations potential candidates merit believed resist classical quantum computers applying shor algorithm quantum computer discrete logarithm algorithm breaks classical schemes infeasible article propose assess benchmark reliable constructions stateless hash based signatures architectures believed one prominent post quantum schemes offering security proofs relative plausible properties hash function however well known confidentiality guarantee reliable architectures presence natural malicious faults propose benchmark fault diagnosis methods post quantum cryptography variant case studies hash functions present simulations implementations results application specific integrated circuit evaluations show applicability presented schemes proposed approaches make hash based constructions reliable natural faults help protecting malicious faults tailored based resources available different reliability objectives
metabolomics powerful emerging tool identification biomarkers exploration metabolic pathways high throughput manner administration site percutaneous absorption skin variety metabolic enzymes except hepar however technologies fully detect dermal metabolites remain lacking skin metabolomics studies mainly focused regulation dermal metabolites drugs metabolism drugs skin metabolomics techniques include collection preparation skin samples data collection data processing analysis furthermore studying dermal metabolic effects via metabolomics provide novel explanations pathogenesis dermatoses unique insights designing targeted prodrugs promoting drug absorption controlling drug concentration paper reviews current progress field skin metabolomics specific focus dermal drug delivery systems dermatosis published elsevier behalf institute pharmacology polish academy sciences
facial expression important channel human nonverbal communication paper presents novel effective approach automatic facial expression recognition based muscular movement model mmm contrast existing methods mmm deals issue viewpoint anatomy first automatically segments input face frame localizing corresponding points within muscular region reference using iterative closest normal point set features multiple differential quantities including coordinate normal shape index values extracted describe geometry deformation segmented region meanwhile analyze importance muscular areas score level fusion strategy exploited optimize weights genetic algorithm learning step support vector machine hidden markov model finally used predict expression label respectively experiments conducted dfe dfe databases results achieved clearly demonstrate effectiveness proposed method
study microstructure texture deformation metallic materials necessitates detailed information physical evidence plastic deformation mechanism involves direct relationship mechanical properties behaviours working conditions generally mechanical properties materials essentially function structure compositions study texture deformation mechanical parts efficient way manufacturing engineering considerable practical interest present paper entails study deformation mechanism microscopic scale situ observation microstructure texture deformation using ray computed tomography medical scanner installed cnam paris industrial materials laboratory evaluating plastic deformation mechanism tomographic inner health analysis presented slices examined parts laboratory scale received heat treated aluminium specimens elsevier rights reserved
working memory executive memory process allows transitional information held manipulated temporarily memory stores forgotten encoded long term memory working memory necessary everyday decision making problem solving making fundamental process daily lives older adults working memory relies heavily frontal lobe structures known decline age current study aimed determine neural correlates decreased working memory performance frontal lobes comparing cortical thickness cortical surface area two demographically matched groups healthy older adults free cognitive impairment high versus low back working memory performance average age high resolution structural weighted images isotropic voxels obtained philips mri scanner compared high performers low performers exhibited significantly decreased cortical surface area three frontal lobe regions lateralized right hemisphere medial orbital frontal gyrus inferior frontal gyrus superior frontal gyrus fdr significant differences cortical thickness groups proxy neurodegenerative tissue loss results suggest decreases cortical surface area proxy brain structural integrity right frontal regions may underlie age related decline working memory function
generally software engineering economical perfect way provide much needed boost present software system software engineering like obtain fully completed software existing software additional features needed overall process software engineering analyze needed requiements contents also changes needed contents transforms existing software system reconstructing novel software system difficult part engineering understand traditional system software engineering mechanisms aimed achieve common engineering objectives objectives improved software quality reduced complexity reduce maintenance cost increased reliability result several traditional engineering mechanisms fail verify performance individual functionality existing software performance evaluation increases complexity engineering process minimizing complexities software engineering proposed system implements novel approach named enhanced engineering mechanism enhanced mechanism introduces new idea executing build process developer verifies performance particular function existing system function performance compared proposed algorithm based comparison process rebuild process carried finally proposed mechanism reduces complexities software engineering
cross sectional cohort healthy women aged years data density structure strength distal radius tibia obtained using high resolution peripheral quantitative computed tomography pqct adjusted age weight height age dependent patterns change differed sites trabecular cortical compartments postmenopausal women trabecular bone remained relatively stable distal tibia cortical compartment changed significantly cortical porosity exhibited weak correlation stiffness aim study provide information age related weight related height related changes volumetric bone mineral density vbmd structure biomechanical parameters cortical trabecular compartments healthy female population using pqct cross sectional brazilian cohort women aged years age related reference curves vbmd structure biomechanical parameters distal radius distal tibia constructed adjusted weight height comparisons premenopausal postmenopausal women performed reference curves obtained parameters age related changes varied cortical thickness trabecular separation changes varied cortical porosity exhibited largest percent changes premenopausal women remained constant postmenopausal women structural trabecular parameters trabecular number trabecular thickness change whereas cortical parameters stiffness significantly altered cortical vbmd showed greatest absolute decrease sites slopes highly negative menopause pearson correlations stiffness pct parameters revealed significant correlation densities structures trabecular cortical compartments weak correlation observed data provide reference curves healthy women demonstrate density structural biomechanical parameters differ radius tibia trabecular cortical compartments postmenopausal women trabecular bone remained relatively stable tibia site whereas cortical compartment changed significantly
people perceive memories moral beliefs changed would change investigated individuals respond way study participants judged identity would change changes memories widely shared moral beliefs murder versus preferences controversial moral beliefs abortion extent participants judged changes would affect relationships predicted identity change study mediated relationship type moral belief perceived identity change study discuss role social relationships play judgments identity highlight implications psychology philosophy
review principles based aggression rendered abnormal humans laboratory rodents comparatively overview main methodological approaches based behavior studied two categories subjects appears discriminating property abnormal aggression rule breaking renders aggression dysfunctional point view perpetrator show rodent models abnormal aggression created translation human conditions rodent equivalents discuss findings obtained models may translated back human conditions mechanisms underlying aggression possibilities treatment investigated suggest complementary nature human rodent research approaches invite intense cross talk two sides aggression research one presently observed elsevier ltd rights reserved
purpose review past years important changes development liver transplantation around world particular several emerging countries rapidly developed transplant programs also important changes liver allocation utilization donors cardiac death living donors review practices different countries around world help provide reader better appreciation program well recognition potential areas improvement based experience colleagues recent findings recent series articles published journal liver transplantation summarizing practice liver transplantation representative countries around world summary volume liver transplant varies widely country important growth volume emerging countries liver transplant candidates prioritized surgery model endstage liver disease score exception germany usa patients transplanted model endstage liver disease score hepatitis common indication liver transplant notable exception several european countries innovative strategies incentivize donation developed several countries
effort address healthcare disparities lesbian gay bisexual transgender queer lgbtq populations many hospitals clinics institute diversity training meant increase providers awareness sensitivity patient population despite efforts many healthcare spaces remain inhospitable lgbtq patients loved ones even absence overt forms discrimination lgbtq patients report feeling anxious unwelcome ashamed distrustful healthcare encounters argue negative experiences produced variety subtle ostensibly insignificant features healthcare spaces interpersonal interactions called microaggressions healthcare spaces providers often convey heteronormative microaggressions communicate lgbtq suggest intersex asexual people identities experiences relationships abnormal pathological unexpected unwelcome shameful identify heteronormative microaggressions common healthcare settings specify negatively impact lgbtqia patients argue standard diversity training sufficiently address heteronormative microaggressions despite challenges healthcare institutions providers must take responsibility heteronormative microaggressions take steps reduce frequency mitigate effects lgbtqia care conclude offering strategies problem solving level medical education institutional culture policy individual awareness
attenuation standard analog low pass filters low frequencies integer multiple dec order attain intermediate values roll factors dec would required employ fractional order filter fractional order filters infinite dimensional representation thus finite dimensional approximations computed decomposition fractional order low pass filters weighted sum standard analog one pole filters optimum weights positioning poles computed using optimization strategies acquired weights poles laid state space representation uniform platform representing time varying systems linear systems well nonlinear systems magnitude phase response fractional order filters represented bode plots
midst rising tension china japan two powerful countries asia favorable attitudes country citizens toward country dropped historical low taiwan issue historical legacy island disputes maritime resource competition major obstacles sino japanese relations fundamental issue deep seated mutual distrust suspicion two countries result rising threat perceptions beyond structural political elite centered approaches study examines evidence related three approaches face face contact cross cultural exposure social identity reduce mutual distrust antipathy two countries careful analysis survey data study sheds light conditions contact results improved attitudes toward outgroup little effect intergroup relations yields prejudice hostility toward outgroup findings study identify factors could facilitate mutual understanding chinese japanese people favorable impressions one another also relevant planning interventions reduce prejudice distrust among people different races religions countries
exact number patients chronic kidney disease ckd asia pacific uncertain numeric terms region home largest population patients untreated chronic kidney failure climatic geographic social cultural economic environmental diversity within region higher part world large parts region face climate related burden infectious diseases infections contribute development progression ckd complicate course patients pre existing ckd especially dialysis therapy immuno suppressed increase cost ckd care contribute mortality morbidity kidney involvement feature several infectious diseases prevalent asia pacific examples include malaria leptospirosis scrub typhus tuberculosis hepatitis virus dengue hemorrhagic fever hantaan virus infections contribution infection associated acute kidney injury overall burden ckd evaluated systematically research needed quantify impact infections kidney health undertaking prospective studies nephrologists need work infectious disease research groups government infection surveillance control programs national kidney foundation inc
background objectives dried pulps peels ziziphus jujuba fruits commonly applied food high nutritional value widely used traditional medicine laxative tonic wound healing agent appetizer aim study evaluate antimelanogenic effects jujuba fruit methods fruit extracts obtained two different extraction methods percolation cold extraction soxhlet hot extraction using methanol solvent total phenolic flavonoid contents dpph radical scavenging activity antityrosinase capacity meoh extracts jujuba fruits evaluated vitro addition effects fruit extracts melanin content cytotoxicity human melanoma skmel cells determined hours results amount total phenolic flavonoid contents cold extract found higher comparison hot extract moreover antioxidant anti tyrosinase activities cold extract significantly stronger hot extract dose cold extract showed weaker toxicity melanoma cells hot extract melanin content cold extract reduced concentration hot extract inhibitory effect melanin formation conclusion results showed percolation method suitable extraction poly phenolics jujuba fruits addition results tyrosinase activity melanin content assays suggested cold extract jujuba fruit considered dermatological whitening agent skin care products
investigate porosity evolution selective laser melting slm inconel alloy transient mesoscale model randomly packed powder bed proposed finite volume method fvm taking consideration phase transition variation thermo physical properties interfacial force thermodynamics within molten pool resulting porosity evolution behavior set laser scanned tracks various laser scanning speeds studied using numerical approach results evidently revealed operating peak temperature reduced obviously increasing scanning speeds accordingly high cooling rate short lifespan limiting depth pool small velocity molten liquid flow obtained high scanning speed scanning speed played crucial role determining type porosity terminally slm processed inconel components high scanning speed top surface primarily dominated open porosity accompanying large sized inter layer porosity cross section due limiting energy input penetrated powder bed incomplete melting powder contrast relatively low scanning speed employed top surface appeared smooth free less metallurgical porosity apparent inter layer porosity cross section surface attributing escaping porosity indicating well metallurgical bonding neighboring layer towards building direction simultaneously physical mechanism thoroughly discussed simulated distribution porosity found consistent experimental measurements
background besides genetic factors known trace elements selenium copper zinc essential thyroid gland fuction thyroid hormone metabolism moreover metals effect suggested patterns associated overt thyroid disease aim study hashimoto thyroiditis chronic autoimune inflamation thyroid gland cosequtive hipothyroidism common disease serbia thought worthwile explore potential effects essential toxic metals metalloides thyroid function ability restore euthyroid status results cross sectional case control study investigated status essential elements selenium copper zinc toxic metals metalloides blood female patients hashimoto thyroiditis overt hypothyroidism compared female healthy persons tried establish presence correlation previous mentioned elements thyroid function hypothyroid patients healthy participants conclusions results study suggested blood concentration essential trace elements especially ratio copper selenium may influence directly thyroid function patients overt hypothyroidism thus findings may implication life long substitution therapy terms thyroxine dose reduction furthermore first time study shown potential toxic effect cadmium thyroid function patients may implicate dose thyroxine substitution
maple package times time series analysis new feature improvement forecasting phase space reconstruction optional argument computational routines allows researcher choose different number steps ahead forecast update extends running package new feature current versions maple software
non ige mediated gastrointestinal food allergic disorders non ige including food protein induced enterocolitis syndrome fpies food protein induced enteropathy fpe food protein induced allergic proctocolitis fpiap relatively uncommon infants young children likely diagnosed non igegi favorable prognosis majority resolving age years diagnosis relies recognition symptoms pattern fpiap fpies biopsy fpe studies needed better understanding pathomechanism lead eventually development diagnostic tests treatments limited evidence supports role food allergens subsets constipation gastroesophageal reflux disease irritable bowel syndrome colic immunologic pathomechanism fully understood empiric prolonged avoidance food allergens limited minimize nutrient deficiency feeding disorders food aversions infants
objective determine opinion nursing faculty researcher effectiveness non verbal communication classroom methods descriptive study included nursing professors filmed minutes fourteen aspects non verbal communication evaluated opinions effectiveness non verbal communication expressed simple frequencies results professors identified postures coherent good effective adequate facial expressions efficient positive reinforcing following speech voice rhythms effective good adequate speed physical energy levels good rhythm active attentive effective adequate alert body postures kept moving standing remaining feet using hand movements illustrate points attention focused students position close students desks less frequent inefficient non verbal communication seen among conclusion nursing professors opinions non verbal communication classroom general non specific indicating inadequate application non verbal communication professors identified inefficient non verbal communication behavior less often one current researchers
background interest natural antioxidants especially polyphenols growing thanks positive contribution human health thus prevention harmful action oxidative stress involved many diseases cancer inflammation diabetes cardiovascular illness recent research proved bioactive compounds richness date seeds could good biological matrix natural antioxidants unfortunately important quantity tunisian dates seed discarded yearly methods study different solvents extraction water methanol absolute acetone aqueous acetone used evaluation effect phytochemical level vitro antioxidant activities vitro hyperglycemia key enzymes inhibition vivo anti inflammatory proprieties established tunisian date seeds results result revealed polar solvent exhibited highest amount bioactive compounds correlation polyphenol compounds antioxidant potentiality explains powerful effect used polar solvents inflammation tbars hyperglycemia inhibition furthermore showed higher capacity scavenge radicals conclusions therefore big waste tunisian seeds could used cheap source natural antioxidant compounds considered health challenge poor countries
study concentrates finding truncated impossible differentials substitution permutation networks spns ciphers instead using miss middle approach authors propose mathematical description truncated impossible differentials first prove truncated impossible differentials rounds spn cipher could obtained searching entry denotes differential pattern matrix dpm layer thus length impossible differentials spn cipher upper bounded minimum integer entry second provide two efficient algorithms compute dpms bit shuffles matrices using tools prove longest truncated impossible differentials spn structure round layer designed maximum distance separable mds matrix finally truncated impossible differentials advanced encryption standard aes aria aes mds present maya puffin obtained
thiamine vitamin deficiency brain implicated development dementia symptoms depression indirect evidence suggests thiamine may contribute pathologies controlling activities glycogen synthase kinase gsk beta decreased gsk beta activity appears impair memory increased gsk beta activity associated distressed depressed state however hitherto direct evidence effects thiamine gsk beta function reported administered thiamine bioavailable precursor benfotiamine day weeks cbl mice determine whether treatment might affect behaviours known sensitive gsk beta activity whether administration impacts gsk beta expression within brain mice tested models contextual conditioning extinction day rat exposure stress test modified swim test repeated testing tricyclic antidepressant imipramine day administered positive control effects thiamine benfotiamine imipramine compounds inhibited upregulation gsk beta induced predator stress repeated swimming reduced floating scores predator stress induced behavioural changes anxiety exploration coincident thiamine benfotiamine improved learning extinction contextual fear acquisition step avoidance task data indicate thiamine benfotiamine antidepressant anti stress effects naive animals associated reduced gsk beta expression conditioning adverse memories thus thiamine benfotiamine may modulate gsk beta functions manner dependent whether contextual conditioning adaptive maladaptive elsevier inc rights reserved
goal two part study identify perceived influence sexuality messages parents peers school media four microsystems within ecological model emerging adult college women sexual attitudes findings suggest parents likely source message remain abstinent marriage participants reported message influential coming school media school media likely sources messages safe use protection use birth control get pregnant college women reported message use protection influenced sexual behaviour however came parents school came school media results implications future prevention programming specifically respect messages without generalising beyond data parents school appear influential peers media thus leveraged development new sex education safer sex programmes
new technologies become important support monitoring older people outdoor environments caregivers smart phones equipped rich set powerful sensors allowed ubiquitous human activity recognition mobile platforms low cost ambient intelligence ami emergent area provides useful mechanisms allows tracking elderly people opportunistic sensoring using smartphone devices paper aims show second version saferoute ami system fusions geo localization sensors data embedded smartphone devices monitoring elderly people version improves functionalities previous one inclusion new ones two components system android application careofme web system saferoute proposed system merges localization data gps wifi sensors data android includes use googlemaps functionalities android web environments provide alerts caregivers
vast majority practical engineering design problems require simultaneous handling several criteria sake simplicity priori preference articulation one turn many design tasks single objective problems handled using conventional numerical optimization routines however situations acquiring comprehensive knowledge system hand particular possible trade offs conflicting objectives may necessary calls multi objective optimization aims identifying set alternative pareto optimal designs popular solution approaches include population based metaheuristics unfortunately methods practical problems involving expensive computational models particularly case microwave antenna engineering design reliability requires utilization cpu intensive electromagnetic analysis work discuss methodologies expedited multi objective design optimization expensive simulation models solution approaches present rely surrogate based optimization sbo paradigm design speedup obtained shifting optimization burden cheap replacement model surrogate latter utilized generating initial approximation pareto front representation well front refinement elevate high fidelity simulation model level demonstrate several application case studies including wideband matching transformer dielectric resonator antenna ultra wideband monopole antenna dimensionality design spaces considered examples vary six fifteen design optimization cost one hundred high fidelity simulations respective structure extremely low given problem complexity elsevier rights reserved
normality homoscedasticity assumptions linear discriminant analysis lda known optimal terms minimising bayes error binary classification heteroscedastic case lda guaranteed minimise error assuming heteroscedasticity derive linear classifier gaussian linear discriminant gld directly minimises bayes error binary classification addition also propose local neighbourhood search lns algorithm obtain robust classifier data known non normal distribution evaluate proposed classifiers two artificial ten real world datasets cut across wide range application areas including handwriting recognition medical diagnosis remote sensing compare algorithm existing lda approaches linear classifiers gld shown outperform original lda procedure terms classification accuracy heteroscedasticity compares favourably existing heteroscedastic lda approaches gld requires much times lower training time datasets comparison support vector machine svm also shows gld together lns requires much times lower training time achieve equivalent classification accuracy datasets thus algorithms provide cheap reliable option classification lot expert systems authors published elsevier ltd
physician implicit racial bias found predict racial minority patients reports satisfaction trust immediately engaging racially discordant medical interactions suggests physician implicit racial bias somehow manifested physician communication behaviors noticed patients medical interactions however unclear exactly physician implicit racial bias manifests behaviorally racially discordant medical interactions authors argue lack understanding might due several limitations existing patient physician coding systems order advance research patient physician communication racially discordant medical interactions new coding systems tailored racially discordant medical interactions required specifically suggested coding systems need capable assessing physician nonverbal paraverbal communication behaviors found positive negative racial minority patients likely requires innovative research approaches mixed methods approach
paper study acceleration applications require searching occurrences thousands string patterns input data stream using automata processor purpose use two applications two fields namely network security bioinformatics first application called fast snap fast snort using scans network data signatures intrusion derived popular open source snort database using resources single board fast snap scan signatures gbps second application called protomata protein automata looks occurrences protein motifs prosite database protein sequences protomata half million times faster single cpu based counterpart techniques developed program applications may useful design development similar applications using new hardware accelerator
background major depressive disorder mdd disabling mood disorder despite known heritable component large meta analysis genome wide association studies revealed replicable genetic risk variants given prior evidence heterogeneity age onset mdd tested whether genome wide significant risk variants mdd could identified cases subdivided age onset methods discovery case control genome wide association studies performed cases stratified using increasing decreasing age onset cutoffs significant single nucleotide polymorphisms tested nine independent replication samples giving total sample cases control subjects subsetting polygenic score analysis used examine whether differences shared genetic risk exists earlier adult onset mdd commonly comorbid disorders schizophrenia bipolar disorder alzheimer disease coronary artery disease results identified one replicated genome wide significant locus associated adult onset years mdd odds ratio confidence interval using polygenic score analyses show earlier onset mdd genetically similar schizophrenia bipolar disorder adult onset mdd conclusions demonstrate using additional phenotype data previously collected genetic studies tackle phenotypic heterogeneity mdd successfully lead discovery genetic risk factor despite reduced sample size furthermore results suggest genetic susceptibility mdd differs adult earlier onset mdd earlier onset cases greater genetic overlap schizophrenia bipolar disorder
introduction recent advance concerning levothyroxine therapy development novel oral formulations liquid preparation soft gel capsule areas covered review evaluates recent clinical studies new formulations liquid formulation shown overcome food beverages intereference tablets absorption caused food coffee breakfast malabsorption induced increased gastric resulting atrophic gastritis due proton pump inhibitors malabsorption bariatric surgery use liquid studied also pregnancy newborns infants suggesting better bioequivalence tablets finally liquid active tablets control thyroid stimulating hormone tsh hypothyroid patients without malabsorption drug interference gastric disorders leading hypothesized higher absorption liquid also patients studies evaluated soft gel promising results patients malabsorption related coffee gastritis expert opinion liquid soft gel capsules active tablet control tsh hypothyroid patients gastric disorders malabsorption drug interference also patients without absorption disorders
concept intergenerational transmission intimate partner violence ipv important topic research experts contended brutal path violence transmitted subsequent generations may avoidable study examined whether public perceptions legal regulation ipv certainty sanction deter prevalence ipv data households obtained nationwide survey conducted south korea due skewed distribution prevalence ipv study applied zero inflated poisson zip model shown address issues skewed count variables addition use zip model allowed examine factors associated occurrence frequency ipv results showed child abuse experience perceptions law associated occurrence ipv individuals experienced child abuse likely perpetrate ipv whereas aware law less likely perpetrate ipv witnessing ipv parents associated increased frequency ipv results suggest increasing awareness laws domestic violence ipv may reduced prevented
authors developed versatile ultrasound simulator proposed system achieves main features high fidelity device exploiting low cost rapid prototyping hardware hand guided ultrasound simulator probe includes rfid reader dof inertial sensor unit consisting accelerometer magnetometer gyroscope microcontroller performs real time data acquisition processing transmission estimated pose information visualization system proper ultrasound view generated since probe orientation main information involved pose reconstruction work presents investigates several tracking methods probe orientation exploiting sensor fusion technique filter noisy measurements coming inertial sensors performances kalman filter nonlinear complementary filter quaternion based filter inertial trackers tested means robot manipulator terms readiness accuracy stability estimated orientation signal results show nonlinear complementary filter quaternion based filter match application requirements rmse deg variance deg settling time involve lower computational time respect kalman filter
views materialisation well known context relational databases however unlike relational databases semantic graph model lacks restrictive structure instead semantic data rely evolving schema resulted challenge views materialisation allowing open repositories data emerge open repositories combine knowledge many different areas therefore assumed various data structures within repository may exhibit different daily access patterns user interests change day research verifies assumption proposes new views selection model analysing access patterns individual views contribute overall system workload proposed model aims selection candidates offering highest reduction peak workload proposed selection method integrated part new optimisation framework operates proxy sparql enabled database approach potential accelerate adaptation views materialisation sparql proposed approach evaluated experimentally using qualitative analysis
protein tyrosine kinases belonging janus kinase jak family associated many cytokine receptors ligand binding regulate important cellular functions proliferation apoptosis differentiation protective effects jak inhibitors fibrotic diseases myelofibrosis bone marrow fibrosis demonstrated previous studies jak inhibitor shr synthetic molecule potently inhibits members jak family particularly jak however effect hepatic fibrosis investigated date best knowledge present study effects shr activation proliferation migration apoptosis hepatic stellate cells hscs well hsc collagen production investigated data demonstrated treatment shr mol exerted inhibitory effect activation proliferation migration hscs addition expression collagen collagen iii significantly decreased following treatment shr furthermore shr induced apoptosis hscs demonstrated annexin staining shr significantly increased activation caspase bax hscs whereas decreased expression bcl shr also inhibited activation akt signaling pathway pharmacological inhibition jak signal transducer activator transcription stat pathway led disruption functions essential hsc growth taken together findings provide evidence shr may potential alleviate hepatic fibrosis targeting hsc functions
ocular surface changes blink abnormalities well established parkinson disease blink rate may influenced corneal sub basal nerve density however relationship yet investigated parkinson disease case control study examined ocular surface patients moderately severe parkinson disease including confocal microscopy cornea fifteen patients moderately severe parkinson disease modified hoehn yahr grade fifteen control participants recruited ophthalmic assessment included slit lamp examination blink rate assessment central corneal aesthesiometry vivo corneal confocal microscopy effect disease laterality also investigated patients parkinson disease ten male mean age years corneal sub basal nerve plexus density markedly reduced patients parkinson disease compared controls corneal sensitivity differ significantly patients parkinson disease mbar control group mbar sub basal nerve density significantly different eye ipsilateral side body severe motor symptoms contralateral eye significant positive correlation ace scores sub basal corneal nerve density first study report significant reduction corneal sub basal nerve density parkinson disease demonstrate association cognitive dysfunction results provide evidence support involvement peripheral nervous system parkinson disease previously thought central nervous system disorder elsevier ltd rights reserved
work presents fully differential operational amplifier opamp design architecture achieves high gain bandwidth low power consumption verification architecture implemented low cost bulk cmos technology chip achieves high gain bandwidth ghz degrees phase margin low power consumption course even better results possible sophisticated technologies like bicmos massively scaled technologies available opamp used analog baseband filters communication systems enables real time ability
introduction five anti tumor necrosis factor anti tnf agents received regulatory approval use rheumatology adalimumab golimumab infliximab certolizumab etanercept apart well documented therapeutic value still uncertain extent associated increased risk infectious adverse events areas covered conducted systematic review meta analysis published randomized studies determine effect anti tnf drugs occurrence infectious adverse events serious infections tuberculosis opportunistic infections infection searched medline embase cochrane library may identify eligible studies adult patients rheumatoid arthritis psoriatic arthritis ankylosing spondylitis evaluated anti tnf drugs compared placebo treatment expert opinion study encompassed data randomized controlled trials involving participants range follow months seven open label extension studies participants range follow months quantitative synthesis available data found statistically significant increases occurrence infections serious infections tuberculosis associated anti tnf drug use data opportunistic infections scarce quality synthesized evidence judged moderate evidence registries long term epidemiological studies needed better define relationship anti tnf agents infection complications
group french medical experts developed guidelines delphi progressive consensus smoking management cigarette era lack scientific data cigarettes led experts set recommendations mainly based clinical practice waiting scientific validations validated smoking cessation treatments keep first place prevention treatment tobacco induced damages cigarette experimented large proportion smokers safer product tobacco health professional must answer patients cigarettes smoker questions cigarettes receive information even lack data cigarettes offer much lower risks tobacco dual user high risk returning exclusive tobacco use also optimize nicotine intakes combining nicotine replacement therapy optimizing nicotine intake cigarette smoker wish use cigarette order quit without associated pharmacological treatment accompanied discouraged vaper tired continuing vape accompanied quit specific guidelines also provided adolescents pregnant women patients perioperative periods also pulmonary cardiac schizophrenic patients splf published elsevier masson sas rights reserved
limonene demonstrated important immunomodulatory properties including antitumor effects may alleviate asthma allergies present study anti inflammatory effects limonene investigated ulcerative colitis rat model healthy male sprague dawley rats randomly divided control untreated treatment limonene groups rats disease activity colonic mucosa damage significantly reduced anti inflammatory effects limonene via suppression matrix metalloproteinase mmp gene expression addition treatment limonene significantly increased antioxidant inducible nitric oxide synthase inos cyclooxygenase cox protein expression levels rats decrease prostaglandin pge production transforming growth factor beta tgf beta gene expression increase phosphorylated extracellular signal regulated kinase erk expression levelswere observed rats treated limonene conclusion limonene reduced mmp mrna expression levels via regulation inos cox pge tgf beta erk signaling pathways rat model indicating potential antioxidant anti inflammatory properties
recent changes diagnosis child antisocial behavior provide different methods conceptualizing traditional symptom based diagnoses alternative trait based methods however little research psychology students might use different methods kind instructional formats might amenable teaching students study examined students advanced psychopathology course used symptom based trait based methods conceptualize child antisocial behavior case study format results indicated students perceived symptom based trait based methods providing complementary information students found useful diagnosis implications future directions also discussed
dimensional type kadomtsev petviashvili equation applied describe propagation non linear waves fluid dynamics investigation paper based binary bell polynomials hirota method symbolic computation bilinear form obtained backlund transformations derived bell polynomial bilinear forms besides one two soliton solutions presented coefficient equation affect soliton structure soliton shapes keep unchanged elastic interaction maintain original directions amplitudes except phase shifts
geniposide iridoid glycoside compound purified gardenia jasminoides ellis antiinflammatory pharmacological effects mechanism actions rheumatoid arthritis clarified purpose article investigate pharmacological effects collagen induced arthritis cia rats feasible mechanisms collagen induced arthritis induced injection chicken type collagen emulsion rats orally administered days immunization histological examination showed could attenuate histopathologic changes mesenteric lymph node mln cia rats geniposide inhibited production interleukin promoting production transforming growth factor beta mln lymphocytes mlnls moreover proliferation capability mlnls increased administration addition treatment vivo decreased expressions raf mek erk mlnls results may highlight antiinflammatory effects possible mechanisms mlnls copyright john wiley sons ltd
collaborative approaches increasingly used governments western countries address complex environmental policy problems approaches often bring together diverse actors settings allow joint problem solving however effectiveness collaboration undermined governments choose ignore outcomes collaboration decision making processes paper report findings study drought based collaborative process evaluate extent provincial government ontario canada used recommendations collaborative groups low water response program interviews document analysis personal observations provided data qualitative multi case study analysis three cases chosen collaborative teams made decisions designed balance ecological economic water issues drought institutional analysis development framework provided conceptual foundation evaluating extent collaborative outcomes used government even though provincial government accept important decision made collaborative teams declare severe drought participants generally satisfied outcomes achieved collaboration especially social environmental outcomes challenges revealed study included insufficient capacity lack clear program requirements issues inherent low water elsevier rights reserved
novel amphiphilic hydroquinone derivative alkyl chain phosphate attached hydroquinone moiety chemically synthesized thermal stability distribution organic aqueous phases vitro skin permeability evaluated derivative identified disodium phenylene diisostearyl diphosphate pis infrared mass nuclear magnetic resonance spectroscopies product pis obtained good yield exhibited satisfactory stability neutral solution comparable skin permeability also higher pis susceptible enzymatic hydrolysis tissue phosphatase releases skin tissues thus characteristics indicate novel hydroquinone derivative presented herein pis may serve effective pro hydroquinone skin care applications
study analyzes muscle activity recorded eight channel electromyographic emg signal stream golf swing using iron club exploits information extracted emg dynamics predict success resulting shot muscles arm shoulder left right sides namely flexor carpi radialis extensor digitorum communis rhomboideus trapezius considered golf players similar shots method using gaussian filtering outlined emg onset time estimation channel activation sequence profiling shots player revealed persistent pattern muscle activation profiles plotted insights respect player effectiveness provided inspection emg dynamics revealed pair highest peaks channel hallmark golf swing custom application peak detection automatic extraction swing segment introduced various emg features encompassing feature sets constructed feature sets used individually also decision level fusion prediction shot effectiveness prediction target attribute club head speed ball carry distance investigated using random forest learner detection regression tasks detection evaluates personal effectiveness shot respect player specific average whereas regression estimates value target attribute using emg features predictors fusion decision optimization provided best results equal error rate detection speed distance mean absolute percentage error regression speed distance proposed emg feature sets found useful especially used combination rankings feature sets indicated statistics muscle activity left right body sides correlation based analysis emg dynamics features derived properties two highest peaks important predictors personal shot effectiveness activation sequence profiles helped analyzing muscle orchestration golf shot exposing specific avalanche pattern data players needed stronger conclusions results demonstrate information arising emg signal stream useful predicting golf shot success terms club head speed ball carry distance acceptable accuracy surface emg data collected goal automatically evaluate golf player performance enables wearable computing field ambient intelligence potential enhance exercising long carry distance drive
due modern techniques technologies development thorough attention simulation autonomous variable frequency systems paid advantage electric machine taken basis modeling leaves doubt use aggressive environments designed model two hase brushless electric motor specifically designed connected model pwm inverter describes processes occurring motor also allows simulate abnormal situations predict possible failures study carried building simulation model programming environment matlab simulink
female sex hormones play important role aetiology pathophysiology variety musculoskeletal degenerative diseases postmenopausal women show accelerated disc degeneration due relative oestrogen deficiency resulting narrower intervertebral disc space women age matched men increased prevalence spondylolisthesis increased prevalence facet joint osteoarthritis postmenopausal women also show higher osteoporosis related spine fracture rate particularly thoracic lumbar junction site propose concept low back pain lbp prevalent postmenopausal women age matched men associated physiological changes caused relatively lower level sex hormones menopause women considering hormone replacement treatment hrt consistent efficacy reported menopause associated osteoarthritis depth understanding role gonadal hormones lbp modulation warrants study hrt initiated early postmenopausal phase may protective recurring lbp case cost benefit analysis performed optimal hrt regimen cases women high risk recurring severe lbp author published elsevier singapore pte ltd behalf chinese speaking orthopaedic society open access article license http creativecommons org licenses
ulipristal acetate upa similar efficacy emergency contraception administered ovulation efficacy upa significantly better administered ovulation levonorgestrel lng effective administered ovulation lng taken pre ovulatory post ovulatory phase results shortening lengthening index menstrual cycle respectively whether applies upa known prospective open label clinical cohort study conducted women may march seven hundred women requesting within single act unprotected sexual intercourse index menstrual cycle recruited community family planning clinic hong kong subject received single oral dose upa completed follow ovulatory status time upa administration determined serum progesterone level supplemented menstrual history ultrasound tracking main outcome measure percentage pregnancies prevented ppp ppp significantly higher subjects pre ovulatory compared post ovulatory time upa administration observed pregnancy rate following upa administration significantly lower expected pregnancy rate pre ovulatory group post ovulatory group overall failure rate versus pre post ovulatory groups respectively pre ovulatory administration upa resulted small delay median days whereas post ovulatory administration resulted minimal advancement median day next menstruation compared predicted previous menstrual pattern pre ovulatory subjects post ovulatory subjects deviation next menses days ovulatory status subjects determined based menstrual history spot sonographic finding together serum hormonal profile time recruitment findings confirmed comparable efficacy upa asian population western populations comparison pre post ovulatory use upa novel finding provides insights possible pharmacological action upa tablets provided free charge laboratoire hra pharma involved design execution study drafting final approval manuscript authors conflicts interest declare university hong kong clinical trials registry reference number hkuctr
modulus optimum criterion used analytical design pid controller linear systems dominant dead time however although method usually gives fast non oscillating closed loop responses case large dead time stability margin gets reduced even non stable behavior observed case correction settings needed preserve stability margin describe compare two methods design pid controller based criterion stable first order systems dead time preserve stability margin trying keep maximum performance original settings
aims esc ehra atrial fibrillation ablation long term registry prospective multinational study aims providing accurate picture contemporary real world ablation atrial fibrillation afib outcome methods results total centres european countries participated asked enrol consecutive patients scheduled first afib ablation pre procedural procedural year follow data captured web based electronic case record form overall patients included underwent afib ablation median age years patients lone atrial fibrillation pulmonary vein isolation attempted patients achieved afib related symptoms present inhospital complications occurred one patient died due atrioesophageal fistula one year follow performed median months ablation clinical visit telephone contact contact general practitioner months success rate without antiarrhythmic drugs aads significant portion still aads late complications included additional deaths cardiac vascular causes complications conclusion afib ablation clinical practice mostly performed symptomatic relatively young otherwise healthy patients overall success rate satisfactory complication rate remains considerable significant portion patients remain aads monitoring ablation shows wide variations antithrombotic treatment ablation shows insufficient guideline adherence
skepinone recently reported map kinase inhibitor high potency excellent selectivity invitro invivo however class compounds still act fully atp competitive typei binders furthermore suffer short residence times enzyme herein describe development first typei binders map kinase typei inhibitors interfere spine inducing glycine flip occupying hydrophobic regionsi design approach leads prolonged target residence time binding active inactive states kinase excellent selectivity excellent potency enzyme level low nanomolar activity human whole blood assay promising binding mode proven ray crystallography
mexico entered important dynamic structural changes energy area proof energy reform energy transition law published last december thus important carry studies impacts future politics consumption population study estimate energy demand system using microdata collected households national households income expenditure survey enigh acronyms spanish encuesta nacional ingresos gastos los hogares years period magnitudes fuels smaller one indicating electricity lpg gasoline public transport normal goods lpg inelastic energy source geographic factor shows households north mexico tend consume gasoline whereas south country lowest share lpg expenditure reported rigorous evaluation energy demanded households help policy makers put forward efficient reforms
paper proposed method classifies electroencephalography eeg color imagination data using emotiv epoc headset eeg measurement event related potential erp method brain computer interface bci systems used experiment experiment subjects gaze non flicker visual stimulus color red green blue white yellow proceed imagine color concentrate led light experiments performed dimly lit room flickered visual stimulus made using arduino microcontroller board leds purpose prompting color imagination result obtained significant eeg responses thoughts related certain colors eeg response classified using classification algorithms including support vector machine svm linear discriminant analysis lda artificial neural network ann lda ann without lda addition fivefold cross validation used evaluate performance results found robust electrodes technology developed paper used assist paralyzed individuals elderly elsevier gmbh rights reserved
world first electric vehicle discussed said first experiment electric vehicle performed middle discovery faraday law therefore era called age invention applications electric motor one electric vehicle numerous theories rumors opinions first electric vehicle clarify experiment called first experiment electric vehicle wiley periodicals inc
test cover comprised three different needle punched geosynthetic clay liner gcl products covered cover soil gravelly sand built arsenic rich tailings former gold mine nova scotia canada evaluate performance gcls local climatic conditions gcls examined one untreated two polymer enhanced natural sodium bentonite three gcls different carriers one woven geotextile one scrim reinforced nonwoven geotextile one woven geotextile laminated polypropylene film locations type gcl placed direct contact tailings locations gcl separated tailings cover soil samples gcl tailings cover soil recovered years construction tests show gcl untreated bentonite maintained low hydraulic conductivity cover soil gcl even though significant cation exchange sodium gcl divalent cations tailings soil porewater mole fraction sodium exchangeable sodium percentage esp decreased gcl polymer enhanced bentonite lower hydraulic conductivity cover soil gcl experienced less cation exchange esp decreased standard gcl gcl polymer enhanced bentonite carrier geotextile coated geofilm demonstrated best hydraulic performance regardless thickness cover soil presence initially uncontaminated foundation layer presence foundation layer gcl tailings impeded migration arsenic tailings gcls gcls serving effective barrier arsenic migration
measuring micro features challenging task usually performed using high cost systems generally based technologies narrow working ranges accurate control sensor positions well known image analysis methods photogrammetry would likely lower costs inspection micro features add texture information models however behaviour photogrammetry strongly affected scaling method retrieves model must scaled computation paper experimental study validity hybrid image processing method measuring micro features presented method exploits depth focus method retrieve correct scale photogrammetric model measurement properly designed manufactured specimens performed following adapting german guideline vdi vde part validate method using calibrated specimens proposed system demonstrated promising achieve error less elsevier inc rights reserved
lamotrigine acute antidepressant effects patients bipolar disorder however little information regarding appropriate serum levels lamotrigine time remission start lamotrigine therapy patients bipolar depression naturalistic unblinded prospective pilot study twelve patients depressive symptoms evaluated using montgomery angstrom sberg depression rating scale madrs start treatment time remission blood samples obtained time remission mahalanobis distance used analyze relationship madrs improvement rate serum lamotrigine level furthermore calculated spearman rank correlation coefficient relationship madrs improvement rate serum lamotrigine level produced box plots serum lamotrigine level remission time remission mahalanobis distance patient administered lamotrigine valproic acid differed significantly patients linear relationship serum lamotrigine level madrs improvement rate among patients receive valproic acid median time start lamotrigine therapy remission weeks serum lamotrigine level important impact acute therapeutic effects lamotrigine bipolar depression addition consider different treatment options considered non responders exhibit improvement administration lamotrigine approximately weeks
micro combined heating power micro chp systems becoming important even essential pretend take full advantage available energy efficiency kind systems reaches important savings energy transport processes occur research internal combustion engine ice based micro chp system developed tested specific constraints system uses two cylinder otto engine prime mover coupled electrical alternator uses exhaust gases engine cooling circuit heat micro chp system developed match electrical power typical stirling engine based micro chp unit order later compare systems performance similar circumstances different operating modes tested different engine speeds order find optimum operating point stand alone portable application system performed using recreational sailing boats mobile homes specific considerations taken related boundary conditions sea water transient simulation performed considering boat three different european climates results compared different locations performance equipment shown comparative study based micro chp system performance done sensitivity analysis influence battery size carried conditions ice based proposed micro chp system similar behavior except differences found due electric thermal power ratios systems battery bank size sensitivity analysis reflects limit performance improvement limit caused uniform distribution electrical demand profile
soluble ligand scdol reported disrupt blood brain barrier bbb cerebrospinal fluid csf serum scdol levels measured multiple sclerosis neuromyelitis optica spectrum disorder nmosd disease control patients serum scdol levels higher dcs positively correlated csf serum albumin ratio qalb nmosd csf scdol levels significantly increased compared dcs correlated qalb csf cell counts protein concentrations interleukin levels scdol could involved bbb disruption whereas may contribute cns inflammation nmosd elsevier rights reserved
maladaptive patterns substance use serious social problems pharmacological nonpharmacological treatments available nondrug options may preferable avoid expense adverse side effects psychotropic medication contingency management nondrug social recreational activities ndsras based operant conditioning principles seek decrease substance use means nondrug rewards however efficacy may hindered brain reward circuitry dysfunctional research shows substance abuse biases neural reward systems favor drug induced highs disrupting circadian based rhythms circadian systems also found influence human reward pathways possibly bidirectional relationship exists circadian disturbance substance abuse effects repair abnormal circadian rhythms might help normalize reward response substance abusers positive effects ndsra treatment outcomes phototherapy effective repairing circadian rhythms persons seasonal affective disorder chronobiological conditions article proposes similarly may repair circadian response substance abusers thereby normalizing brain reward systems would enhance efficacy ndsra therapies may also help prevent relapse given low cost ease administration phototherapy seems promising avenue pursue
temporal pole associated diverse functions social cognition emotion processing although underlying mechanism remains elusive one possibility acts domain general hub integrating socioemotional information test participants presented empathy evoking film clips fmri scanning film clips preceded linguistic sad neutral context half clips accompanied sad music line hypothesized role involved processing sad context furthermore tracked participants empathic concern examine neuromodulatory impact applied nonlinear dynamic causal modeling multisensory integration network previous work consisting superior temporal gyrus stg fusiform gyrus amygdala extended additional node bayesian model comparison revealed gating stg fusiform amygdalar coupling increase connectivity integration contextual information moreover backward projections strengthened emotional music findings indicate social cognition integrates information different modalities top modulates lower level perceptual areas ventral visual stream function integration demands
paper presents new model describes physical phenomena occurring individual outer hair cell ohc human hearing organ cochlea new model employs concept parametric amplification piezoelectricity consequence proposed model may explain natural way many yet unresolved problems mechanisms power amplification nonlinearity fine tuning high sensitivity take place human hearing organ mathematical analysis model performed equivalent electrical circuits individual ohc established high selectivity ohc parametric amplifier analyzed solving resulting mathieu ince differential equations analytical formula power gain ohc parametric amplifier developed proposed model direct physical interpretation elements physical counterparts actual structure cochlea numerical values individual elements electrical equivalent circuits consistent experimental physiological data anticipated proposed new model may contribute future improvements human cochlear implants well development new digital audio standards
background atrial fibrillation difficult treat effectively owing uncertainty best ablate eliminate arrhythmogenic substrate model providing insight electrical activation events would useful guide catheter ablation strategy method two dimensional node automaton developed simulate atrial electrical activity substrate field altered presence differing refractory period varying locations fibrosis added form short randomly positioned lines conduction block larger areas block used simulate ablation lesions anisotropy imposed ratio premature electrical impulse one four grid corners utilized initiate activation results rotational activity uninducible refractory patch dimensions less larger refractory regions single premature stimulus capable inducing average rotors often formed near patch edges maximum rotors formed refractory patch dimensions approached size entire left atrial virtual field rotors formed along refractory patch edge wavefront arrival delayed turning points due presence fiber cluster sufficient size however rotational activity could also occur around large fiber cluster without need spatially variable refractoriness obstacles conduction lacking size nascent rotors drifted either extinguished stabilized upon anchoring sufficiently large fiber cluster elsewhere field transient rotors terminated traversing region differing refractory periods obstacle conduction present sufficiently delay wavefront arrival beyond longest refractory period rotors annihilated nearby rotor faster spin rate gradually interrupted activation pathway elimination anchors removal simulated ablation sufficient region prevented rotor onset particular location would otherwise form conclusions presence obstacles conduction spatial differences refractory period important parameters initiating maintaining rotational activity simulation atrial substrate
present study explored presence meaning life search meaning life correlation health anxiety meaning life questionnaire short health anxiety inventory completed individuals results indicated higher presence meaning life associated lower health anxiety opposite observed search meaning life results also revealed interaction presence meaning life search meaning life individuals high search meaning life high presence meaning life lower health anxiety high search meaning life low presence meaning life findings suggest presence meaning life search meaning life correlates health anxiety
context data miners widely used software engineering say generate defect predictors static code measures static code defect predictors perform well compared manual methods easy use useful use one black arts data mining setting tunings control miner objective seek simple automatic effective method finding tunings method experiment different data sets open source java systems ran differential evolution optimizer explore tuning space first step tested tunings using hold data results contrary prior expectations found tunings remarkably simple required tens thousands attempts obtain good results example learning software defect predictors method quickly find tunings alter detection precision conclusion since improvements large tuning simple need change standard methods software analytics least defect prediction longer enough run data miner present result without conducting tuning optimization study implication kinds analytics open pressing issue elsevier rights reserved
double blind placebo controlled gluten challenge proposed confirm diagnosis nonceliac gluten sensitivity ncgs patients without celiac disease respond gluten free diet determine accuracy approach analyzed data double blind placebo controlled gluten challenge trials comprising adults studies varied duration challenge range daily doses gluten challenge range studies administered composition placebo gluten free products xylose whey protein rice corn starch containing fermentable carbohydrates studies found gluten challenge significantly increase symptom scores compared placebo however ncgs patients showed gluten specific symptoms furthermore subjects nocebo response similar increased symptoms response placebo findings reveal heterogeneity potential methodology flaws among studies gluten challenge cast doubt gluten culprit food component patients presumptive ncgs highlight importance nocebo effect types studies
background according rome criteria chronic constipation includes functional constipation irritable bowel syndrome constipation ibs patients meet criteria rome constipation nrc aim study evaluate various clinical presentation management ibs nrc italy methods month period italian gastroenterologists recorded clinical data ibs nrc patients using bristol scale pac sym pac qol questionnaires addition gastroenterologists also asked record whether patients clinically assessed first time follow diagnostic tests prescribed therapies also recorded results eight hundred seventy eight consecutive patients enrolled ibs nrc pac sym pac qol scores higher ibs nrc first gastroenterological evaluation duration longer years specialist consultation requested frequently ibs nrc digital rectal examination performed diagnostic tests prescribed faecal calprotectin thyroid tests celiac serology breath tests frequently suggested ibs anorectal manometry least one treatment suggested chronic constipation frequently dietary changes macrogol fibers antispasmodics psychotherapy frequently prescribed ibs prucalopride pelvic floor rehabilitation conclusions patients ibs reported severe symptoms worse quality life nrc digital rectal examination often performed least one diagnostic test prescribed patients colonoscopy blood tests first line diagnostic tools macrogol prescribed laxative prucalopride pelvic floor rehabilitation represented second line approach diagnostic tests prescribed therapies increased increasing severity
system strains external loads certain amount time influence environmental factors define rheological behavior rheological phenomena depend many factors temperature air humidity moisture content rheological system radiations term intensity duration type geometry parts loadings terms intensity variation duration defects aggressive environment composition material properties combinations factors rheology science based theories strength materials thermodynamics chemistry materials science terms application provides personalized analysis diagnosis according condition structures systems used wooden constructions subjected various loadings short long durations joints elastic flexible failure occurs gradually plastic failure occurs suddenly sudden failure joints caused shear predominant load wood resist shear stresses order study rheological behavior wood joints metal rods constant load three types joints terms diameters bolts stiffening systems tested stressed traction force days real conditions temperature degrees degrees humidity aim tests determine rheological behavior wooden joints variation deformations relation relative humidity temperature rate strain connections determining rheological model wood threaded rods found low temperatures winter degrees correlated high relative humidity led sudden changes strain observed high speed deformation joint largest diameter rod paper highlights rheological analysis joints wooden rods real conditions temperature humidity regards applied tension determination creep function characterizes types connections establishing optimum diameter rods published elsevier ltd
brief presents programmable ultralow power analog neural signal processing system analog hardware implements nonlinear model replicate predict real time temporal neural codes used complex brain functions transistors analog circuits operate weak inversion digital control system used program model parameters calibrate mismatches chip implemented complementary metal oxide semiconductor technology occupies area power consumption system modular design allows easy scaling achieve large scale hardware systems emulate spike transformations populations neurons
objective study aims retrospectively investigate contraceptive methods different reproductive aged women two different regions yangzhou china understand changes contraceptive methods analyze targeted improvements future informed choices contraception birth control reduce occurrence unintended pregnancies materials methods study included married reproductive aged women mcw chosen city downtown county level city respectively group organized random sampling questionnaire survey results significant urban rural difference choice contraceptive methods different mcw female choices contraception single accessibility contraceptive supplies personalized services could improve implementation rate long term contraceptive measures cooperation male contraceptive responsibility related education levels enhanced male female communication conclusions important urban rural women different ages choose different contraceptive measures suggesting choices require development different educational models towards women different ages regions accessibility various aspects counseling contraceptive measures strengthened meanwhile male participation also promoted prevent unwanted pregnancies reduce health hazards related sexual activities
computer network vulnerability analysis method analysis evaluation network security beforehand attacks method occurred network previous network status change input information calculated model analysis forecasting network node may network attacks given current security level value network network security reinforcement measures taken danger administrators proactively identify network security issues take measures advance avoid information leakage financial losses ensure safety individuals countries therefore vulnerability analysis computer network important based properties attack graph shows method attack graphs bayesian network transformation using new algorithm eliminate loops attribute attack graph optimization building bayesian attribute attack graph model used evaluate network security situation model based bayes formula calculating probability new node probability calculation formula attack paths occur calculating network vulnerability assessment quantitative indicators model visually process description cyber attacks also bayesian network probabilistic thinking possible network attack path prediction assessment
allergen immunotherapy ait use since one century leonard noon experimentally proved efficacy hayfever noon lancet since ait administered subcutaneous injections scit sublingual route slit proposed use slit proposed following several surveys usa repeatedly reported fatalities due scit lockey allergy clin immunol lockey allergy clin immunol committee safety medicines csm update desensitizing vaccines med reports raised serious concerns safety risk benefit ratio ait many cases life threatening events scit due avoidable human errors administration relevant fraction remained unexplained unpredictable aaronson gandhi allergy clin immunol subsequently years slit gained credibility included official documents guidelines table bousquet allergy clin immunol supp canonica allergy supp viable alternative traditional scit note local bronchial aerosol intranasal route administration attempted alternatives scit bronchial route soon abandoned due poor efficacy side effects local nasal route although effective safe judged substantially impractical canonica passalacqua allergy clin immunol contrast scit slit tested large clinical trials need references including hundreds patients dose ranging experimental designs products tablets grass mite ragweed officially approved commercial drugs regulatory agencies food drug administration european medicines agency optimal content maintenance dose identified selected allergens parallel knowledge mechanisms action ait rapidly refined leading improvements chemically modified extracts use adjuvants enhance efficacy safety addition last years increasing scientific clinical interest ait applied food allergies particular children use orally administered extracts albin nowak wegrzyn immunol allergy clin north results far encouraging least cow milk egg peanut although use treatment still restricted clinical trials within specialized centers finally introduction molecular component resolved diagnosis allowed detailing prescription ait better delineating true sensitization versus cross reactivity canonica world allergy organ latter point also strict relation use recombinant engineered highly purified molecules instead raw extracts desensitization process
cognitive dysfunction schizophrenia scz alzheimer disease major driver functional disability largely unresponsive current therapeutics animal models cognitive dysfunction relevant disorders suggest alpha nicotinic acetylcholine receptor nachr may promising drug development target multiple clinical trials subsequently testing hypothesis individuals scz however translational value rodent cognitive tasks predicting overall efficacy therapeutic target clinical trials unknown compare effect sizes rodent human studies searched pubmed cochrane library randomized placebo controlled trials compounds pharmacological activity alpha nachr treatment cognitive dysfunction scz identified studies comprising subjects treated eight different compounds acting full partial agonists cognitive outcomes standardized random effects meta analyses revealed statistically significant effects alpha nachr agonists overall cognition eight cognitive subdomains doses included range cognitive outcomes cohen negative favoring drug contrast analysis rodent studies testing agonists revealed large effect sizes multiple commonly used preclinical behavioral tests cognition range results suggest targeting alpha nachr agonists robust treatment cognitive dysfunction scz necessitate better understanding translational gap therapeutics targeting nachr elsevier inc rights reserved
studies investigated relationship post natal inflammatory biomarkers early age child neurodevelopment outcomes main aim study examine relationship beta cytokines well cortisol months age neurodevelopment psychological problems months age study conducted sample full term newborns followed months age infant neurodevelopment assessed using bayley scales infant development psychological problems assessed child behavior checklist cbcl mother emotional symptoms assessed general health questionnaire infants months old beta cytokines cortisol measured blood samples results showed higher months predicted higher scores internalizing emotionally reactive anxious depressed withdrawn attention problems externalizing problems aggressive behavior months contrast high levels beta months related worse motor skills inflammatory biomarkers related mental performance beta could early markers later psychological problems psychomotor disabilities elsevier rights reserved
fado system symbolic manipulator formal language objects implemented python work extend capabilities implementing methods manipulate transducers one level higher existing formal language systems implement methods manipulate objects representing classes independent languages widely known code properties methods allow users define code properties combine fixed properties prefix codes suffix codes error detecting codes etc satisfaction maximality decision questions solvable definable properties new online system laser allows one query code property obtain answer batch mode work founded independence theory well theory rational relations transducers contributes improved algorithms objects
notwithstanding prominent presence psoriatic skin functional role neutrophilic granulocytes still remains somewhat enigmatic sparked exciting scientific discoveries regarding neutrophil functions within last years interest short lived cells innate immune system boosted recently known time neutrophils produce respond number inflammatory mediators recent research linked neutrophils pathogenic functions possibly conjunction formation nets neutrophil extracellular traps antipsoriatic therapies exert effects least part interference neutrophils neutrophils also appear connect psoriasis comorbid diseases however directly tampering neutrophil functions trivial evinced failure therapeutic approaches targeting redundantly regulated cellular communication networks also become apparent neutrophils link important pathogenic functions innate adaptive immune system intricately involved regulatory networks underlying pathophysiology psoriasis order advocate intensified research role interesting cell population highlight features neutrophils put perspective current view pathophysiology psoriasis
objectives systematic review aimed examine empirical evidence concerning efficacy psychosocial interventions ameliorating psychosocial problems people cardiovascular diseases cvds methods comprehensive literature search undertaken identify published non published english randomised controlled trials rcts two reviewers independently screened assessed risks bias extracted data comprehensive meta analysis software used analyse extracted data hedges effect size used determine effects psychosocial interventions results thirty studies included review studies reported significant short term effects psychosocial interventions cvd patients studies report long term effects average effect sizes stress anxiety depression combined depression anxiety respectively post tests numbers became follow assessments psychosocial programmes psychoeducation stress management helped reduce patients stress anxiety levels programmes including psychotherapy counselling mindfulness based intervention mbi stress management helped mitigate depression anxiety conclusions findings support efficacy psychosocial interventions people cvds practice implications healthcare providers monitor patients psychological problems may integrate psychosocial interventions part treatment plans published elsevier ireland ltd
information leakage memory disclosures significant threats security modern operating systems attacker able obtain binary code program possible reverse engineer source code uncover vulnerabilities craft exploits subsequently patch together code segments form code reuse attacks activities particularly concerning program device driver operating system kernel since facilitate privilege escalation ability persist hide execute code way inhibit memory disclosures current bit virtual memory implementation provide capability enforce execute access permissions authors present implementation exoshim novel line lightweight shim hypervisor layer employing intel commodity virtualization features dynamically inserted beneath running kernel prevent memory disclosures marking code execute unlike alternative approaches operate user level applications exoshim utilizes self protection hiding techniques guarantee integrity even event attacker able gain root level access technology combined fine grained compile load time diversity mitigate additional threat indirect memory disclosures concepts integrated within experimental minix like bit microkernel concepts general could applied operating systems implementation subtle requires detailed understanding kernels interaction virtual memory layer consideration boot time load kernel code kernel data distinct pages memory early evaluations quantify exoshim code size complexity run time performance cost effectiveness thwarting information leakage exoshim provides complete multic like execute protection kernel code runtime performance overhead due advanced modern caching techniques architecture overall paper contributes presentation implementation evaluation lightweight tool enforcing execute access control permissions kernel code using virtualization features modern architecture
aerobic capacity model proposes endothermy product selection favouring high maximal metabolic rates mmr mechanistic coupling basal metabolic rate bmr attempts validate model birds equivocal restricted phenotypic correlations thus failing distinguish among within individual correlations ind examined paired measurements bmr mmr house sparrows two levels experimental manipulation testosterone implants immune challenge overall repeatability significant bmr mmr testosterone treatment altered bmr mmr resulted contrasting effects ind ind high significant sham implanted birds negative marginally non significant testosterone treated birds thus expected mechanistic link bmr mmr apparent birds low testosterone levels
context primary goal traditional treatment rehabilitation programs safely return athletes full functional capacity nontraditional activities rock climbing rodeo typically less training structured coach structured individualism self determination autonomy prevalent observed athletes national collegiate athletic association ncaa sponsored sports limited research available nontraditional athletes provided athletic trainer little insight coping skills adaptations stressors athletes may bring clinical setting especially among growing number women participating types activities better understanding pain coping traits nontraditional competitors would enhance insight triage procedures heading potential athlete related risk factors clinical setting objective quantify compare pain coping traits among individual sport women athletes participating nontraditional versus traditional ncaa structured competition relevance optimal treatment rehabilitation design cross sectional study setting data collected participant respective group meeting seasonal activity participants participants total athletes involved either nontraditional non ncaa individual sports mean age years downhill skiing martial arts rock climbing rodeo skydiving telemark skiing traditional ncaa sports mean age years equestrian golf swimming diving tennis track main outcome measure participants completed sports inventory pain sport specific self report instrument measures pain coping traits relevant competition treatment rehabilitation trait measures direct coping cognitive catastrophizing avoidance body awareness total coping response data grouped analyses type athlete nontraditional traditional results found significant main effect type athlete wilks lambda nontraditional sport athletes scored lower direct coping cognitive catastrophizing total coping response traditional athletes conclusions women participating nontraditional individual sport activity revealed less pronounced pain coping traits women participating coach structured traditional ncaa sports sport medical personnel consider type athlete prescribing training treatment rehabilitation optimal performance return play
create facile external controlled drug delivery system magnetic porous carrier based tin oxide nanoparticles synthesized inexpensive versatile hydrothermal strategy used vitro process magnetic nanocomposites qualified fourier transform infrared ftir scanning electron microscopy sem ray diffraction xrd vibrational sample magnetometer vsm transmission electron microscopy tem results showed nanoparticles synthesized successfully good dispersion magnetic nanoparticles cavity uniform particle size distribution average size high magnetization emu furthermore nano porosity magnetism allowed high efficiency remote controlled drug release study anti migraine sumatriptan used drug sample effect drug concentration ratio loading time drug absorption investigated best result checked stability body temperature different body sample drug concentration loading time highest drug efficiency finally order simulate vivo process vitro step amnion used drug diffusion rate measured different intervals different values result illustrated diffusion reached became constant based mentioned results carrier acceptable vitro yield therefore could chosen future vivo researches elsevier rights reserved
based social cognitive theory leadership theory current study tests theoretical model linking supervisory styles supportive directive graduate student creativity via psychological cognitive factors specifically creative self efficacy intrinsic motivation results sample graduate students university china indicate creative self efficacy intrinsic motivation completely mediate influences supportive supervisory style directive supervisory style graduate student creativity interestingly results indicate positive influence directive supervisory style graduate student creativity inconsistent literature original hypothesis findings verify creative self efficacy indirect effect graduate student creativity influencing intrinsic motivation discuss implications findings theory practice
background mental health treatment gap youth low middle income countries lmics substantial strategies redress urgently needed mitigate serious health social consequences untreated mental illness youth aims estimate burden major depressive episode mde posttraumatic stress disorder ptsd well utilization care among haitian youth order describe mental health treatment gap lmic setting methods estimated point prevalence mde ptsd subthreshold variants school based sample youth ages years using modified structured clinical interview dsm axis disorders scid based interview examined treatment utilization among receiving one diagnoses assessed additional psychopathology self report measures examine validity study diagnostic assignments results combined prevalence full syndrome subthreshold mde ptsd high large majority affected individuals accessed mental health services health sector accessed care kind either health folk sectors past year conclusion findings demonstrate high mental health burden among haiti youth many youth mde ptsd accessing mental health care
urbanisation represents growing threat natural communities across globe small aquatic habitats ponds especially vulnerable often poorly protected legislation many ponds threatened development pollution surrounding landscape yet biodiversity conservation value remain poorly described report results survey ponds along urban land use gradient west midlands outline environmental conditions urban ponds identify local landscape scale environmental variables determine biodiversity conservation value macroinvertebrate assemblages ponds cluster analysis identified four groups ponds contrasting macroinvertebrate assemblages reflecting differences macrophyte cover nutrient status riparian shading nature pond edge surrounding land use availability wetland habitats pond conservation status varied markedly across sites richest macroinvertebrate assemblages high conservation value found ponds complex macrophyte stands floating vegetation low nutrient concentrations little surrounding urban land impoverished assemblages found highly urban ponds hard engineered edges heavy shading nutrient rich waters random forest classification model revealed local factors usually primacy landscape scale factors determining pond conservation value constitute priority focus management
kron reduction used simplify analysis multi machine power systems certain steady state assumptions underly usage phasors using ideas behavioral system theory paper show perform kron reduction class electrical networks called homogeneous electrical networks without steady state assumptions reduced models thus used analyze transient well steady state behavior electrical networks elsevier ltd rights reserved
water shortage pollution serious challenges many countries nanomaterials promising new tools water quality management due unique physicochemical properties high economic benefit high removal efficiency environmental friendliness describe four types nanomaterials used water treatment nanofiltration membranes photocatalytic nanomaterials adsorption nanomaterials reducing nanomaterials discuss properties applications mechanisms pollutant removal also review nanomaterials used water quality monitoring notably nanomaterials used detection trace pollutants pathogens nanomaterials include carbon nanotubes magnetic nanoparticles noble metal nanomaterials quantum dots
rmlwin new package designed run multilevel modeling software program mlwin within environment allows large range models specified take account multilevel structure including continuous binary proportion count ordinal nominal responses data structures nested cross classified exhibit multiple membership estimation available via iterative generalized least squares igls yields maximum likelihood estimates also via markov chain monte carlo mcmc estimation bayesian inference well employing mlwin mcmc engine users request mlwin write bugs model data initial values statements use winbugs openbugs rmlwin automatically calls via rbugs employing igls starting values mlwin users also take advantage mlwin graphical user interface example specify models inspect plots via interactive equations graphics windows rmlwin supported large number examples reproducing analyses conducted mlwin igls mcmc manuals
family planning essential comprehensive treatment plan women reproductive age multiple sclerosis including counseling using effective contraception optimally time desired prevent unintended pregnancies topical review summarizes first evidence based recommendations contraception safety women evidence based recommendations contraceptive use women included medical eligibility criteria contraceptive use developed review published scientific evidence contraception safety consultation experts summarize expand main conclusions centers disease control prevention guidance contraceptive methods appear based current evidence safe women restriction use combined hormonal contraceptives among women prolonged immobility concerns possible venous thromboembolism disease modifying therapies dmts appear decrease effectiveness hormonal contraception although formal drug drug interaction studies limited neurologists help women make contraceptive choices factor level disability immobility medication use women taking potentially teratogenic medications highly effective methods long acting intrauterine devices implants might best option
background literature shown good results partial repairs large massive tears rotator cuff role factors affect reparability less clear purpose study twofold examine clinical outcomes following complete partial repair large massive full thickness rotator cuff tear explore value clinical surgical factors predicting reparability methods secondary data analysis consecutive patients large massive rotator cuff tear required surgical treatment arthroscopic complete partial repair followed two years disability measures included american shoulder elbow surgeons ases relative constant murley score cms shortened version western ontario rotator cuff index shortworc relationship predictors reparability examined logistic regressions chi square statistics appropriate within group change time group differences disability outcomes range motion strength examined student tests non parametric statistics results one hundred twenty two patients women men mean age included analysis large fully reparable partially reparable fully reparable partially reparable massive tears reparability associated age sex pre operative active flexion abduction fully reparable tear group showed better pre operative ases score better active external rotation neutral reparability associated tear shape size tendon quality conclusions reparability large massive tears affected number clinical surgical factors patients whose tears could fully repaired showed statistically significant improvement range motion strength disability years although slightly inferior results compared complete repairs
procedure aimed support designers achieving structural improvements reduce seismic vulnerability electrical network presented method based use askelp software assessment seismic risk electric power grids allows minimising costs actions needed order reach required level reliability defined two different indexes damage namely loss transmitted power number customers excluded service updating plan reinforcement power transmission grid includes identification critical nodes electromechanical components strengthened related reinforcement level paper shown vulnerability assessment carried askelp help finding optimal solution tasks increasing effectiveness costs ratio three different empirical criteria individuation critical nodes evaluated simulation significant part italian transmission grid presented results suggest effective criterion individuating grid critical nodes given terms exclusion probability
fuel cell electric vehicles convert chemical energy hydrogen electricity power motor since cars used transport small part time energy stored board hydrogen tanks fuel cell vehicles used provide power cars parked paper present community microgrid photovoltaic systems wind turbines fuel cell electric vehicles used provide vehicle grid power renewable power generation scarce excess renewable power generation used produce hydrogen stored refilling station central control system designed operate system way operational costs minimized end hybrid model system derived characteristics fuel cell vehicles traveling schedules considered operational costs system formulated considering presence uncertainty prediction load renewable energy generation robust min max model predictive control scheme developed finally case study illustrates performance designed system authors published elsevier ltd
accurate predictions fluid properties density oil formation volume factor bubble point pressure essentials reservoir engineering calculations paper approach based nonlinear system identification modeling nonlinear arx narx hammerstein wiener predictive model proposed forecasting pressure volume temperature pvt properties crude oil systems end two datasets one containing pvt samples different iranian oil reservoirs databank containing data various geographical locations employed construct train evaluate test models simulation results demonstrate proposed narx models outperform previously employed methods including three types artificial neural networks models committee machine multilayer perceptron radial basis function two types anfis models grid partition fuzzy mean several empirical correlations smallest prediction error reliable models predicting oil properties reservoirs engineering among soft computing approaches elsevier rights reserved
paper present smart push system feedback enabled flow control suitable web enabled mobile iot devices push architecture incorporates gateway client gateway server component flow web push notifications controlled delivered device user likely open present overview implementation details smart push system enhanced web push features describe algorithm running gateway server enable push flow control architecture also provides flexibility users move seamlessly across different geographies mobile operating systems like android tizen without changes content provider applications servers also present results experiment performed multiple users measure effectiveness system perform flow control notifications ensure clicked
nonlinear model predictive control nmpc become important tool optimization based control many bio chemical systems requirement well performing nmpc implementation obtaining maintaining appropriate mathematical process model cope model degradation view plant changes system evolution developments made linear systems incorporate information content future measurements closed loop objective however formulations integrated experiment design nonlinear systems ied nmpc remain scarce two different formulations studied paper applied bioprocess namely algae growth described droop model first formulation integration experiment design linear dynamic systems extended nonlinear dynamic systems resulting nmpc formulation integrated experiment design second approach notion economic optimal experiment design incorporated within nmpc formulation economic loss function related inaccurate parameter estimates minimized instead measure parameter variances resulting improved control performance advantage proposed techniques naive experiment design integration approach illustrated monte carlo simulations published elsevier ltd
participation sports promotes health maintains good habits entails risk injury present article uses multivariate analysis examine relationship type injury location injury sport soccer basketball volleyball gymnastics county practiced age five european union countries knowledge relationships used develop specific strategies improve prevention reduce injuries occur
objective aim study analyze mirnome pancreatic ductal adenocarcinoma pdac preneoplastic lesion intraductal papillary mucinous neoplasm ipmn find new microrna mirna based biomarkers early detection pancreatic neoplasia objective effective early detection methods pdac needed mirnas good biomarker candidates methods pancreatic tissues obtained patients pdac ipmn control individuals hospital clinic barcelona biomarker discovery done using next generation sequencing discovery set surgical samples pdac ipmn mirna validation carried quantitative reverse transcriptase pcr different set samples set surgical samples pdac ipmn chronic pancreatitis set endoscopic ultrasound guided fineneedle aspirations pdac ipmn results mirnas significantly deregulated pdac ipmn versus mirnas commonly overexpressed pdac ipmn selected validation among significant regulation mirnas confirmed quantitative reverse transcriptase pcr samples set set respectively conclusions mirnome analysis shows pdac ipmn differential mirna profiles respect large number deregulated mirnas shared neoplastic lesions indeed identified validated mirnas whose expression significantly increased pdac ipmn lesions feasibility detecting mirnas endoscopic ultrasound guided fine needle aspiration samples makes good biomarker candidates early detection pancreatic cancer
expanding concept green building sustainable development implemented across various infrastructure systems performance metrics rating systems developed measure economic social environmental impacts development process transportation sector adapted development sustainable rating systems greenroads focuses roadway planning design construction efforts support sustainable modes pedestrian cycling led development new transportation rating systems greenpaths greenpaths rating system developed part previous research project includes sustainable performance metrics related planning location design construction safety maintenance shared use pathways research builds development rating system explores feasibility applying greenpaths various pathway development phases existing development proposed therefore rating system applied three case study phases along buffalo valley rail trail union county results case study applications provide insight implementation process three different development phases well opportunity rating system improvement results show using rating system earlier planning design phase lead improvements integration sustainable practices greenpaths case studies serve examples implement rating system real world pathway projects support development sustainable transportation systems
worldwide mobile software market grown dramatically since feature phones became popular early practice mobile usability defined resource constrained device two ways namely user experience user interface regarded key gaining superiority terms market share customer loyalty unfortunately facto standards software design development process unified modeling language uml rational unified process rup seem promote mobile usability systematic manner practice paper proposes systematic generalizable approach modeling evaluating properties mobile usability herein treating first class software quality perspective software engineering devise evaluation framework mobile usability call evaluation framework uef throughout paper specified inter scene interactions users terminals software products using extended menu navigation viewpoints emnvs model checker nusmv adopted observe whether emnv model meets set given properties importantly analysis design rup extended support design major roles activities artifacts explicitly monitored controlled stakeholders case studies demonstrate uef works properly treat software products prioritize mobile usability consequently uef plays key role filling gap two research disciplines address usability software engineering human computer interactions
harmful accident student school liability subject subjective offence act objectively legal liability student accordance provisions existing laws regulations object compensation usually schools teachers third people suppose school teachers bear responsibility compensation increase sports activities school teachers pressure hindered healthy development school sports activities harm indemnity third party right people get compensation third people affected economic conditions factors learn foreign experience transfer risk existing compensation duty subject insurance companies sports injuries compensation fund situation conducive timely rescue conducive normal development physical activities
usually fish canning industrial wastewaters highly variable composition time good performance treatment processes necessary limit variation however extended wastewater monitoring including relevant analytical parameters expensive work proposes efficient approach minimize analytical determinations number without compromising global characterization goal way fish canning industry wastewaters variability assessed interpreted multivariate statistical tools application analytical data obtained monitoring program carried fish canning industry northern portugal physicochemical parameters determined samples collected months period results achieved correlation analysis principal component analysis pca cluster analysis led main water pollution sources identification minimization physical chemical parameters number analyzed order achieve correct wastewater characterization minimum cost main pollution sources proved brine eviscerating step waters dissolved organic carbon doc total suspended solids tss conductivity one parameters identified important parameters must monitored order obtain accurate characterization allowing define appropriate wastewater treatment institution chemical engineers published elsevier rights reserved
purposethis study aimed investigate effects shared decision making sdm training program self esteem problem solving ability quality life people schizophrenia design methodsa quasi experiment nonequivalent control group pre posttest design conducted self esteem scale problem solving ability scale whoqol scale used findingsthe sdm training program effective improving self esteem problem solving ability quality life people schizophrenia practice implicationsthe sdm training program used various mental health fields hospitals mental health centers rehabilitation facilities
advancements recently developed timber products application within prefabrication process require construction management processes standardized unified processes need scientifically proven cross company references apart technical developments especially terms cost savings standardization building procedures professionalization also plays fundamental role providing practical application long term success market current demand mass appeal timber accompanied various economical key factors addition question technical standardized system components provide long term stability regarding costs consistent quality construction management optimization sustainability according research paper integration consistent data workflow planning production installation process allows significantly shortened construction period major site cost reduction well sustainable approach delivering holistic construction management system timber identified criteria surveyed fundamentals used create general construction management methods branch additionally applicability analyzed consistently determine future potential generate appropriate integral timber building systems modern timber construction methods especially suitable prefabrication material specific properties sustainable performance possibilities prefabrication easier assembly dry construction conditions reason high productivity combined excellent quality short installation periods provides verifiable arguments best practice examples area construction management modern timber building systems published elsevier ltd
paper describes participant user study compares two widely known systems supporting end users creating trigger action rules internet things ambient intelligence scenarios user study first stage research agenda concerns implementation novel conceptual framework design continuous evolution sentient multimedia systems namely socio technical systems people many kinds hardware software components sensors robots smart devices web services etc interact one another exchange multimedia information give rise intelligent proactive behaviors conceptual framework structured along three layers physical inference user based information space events conditions actions linked together event condition action rules operating according interconnection metaphor results user study provided indications implementation user layer suggesting could suitable interaction style rule design community end users family issues addressed wide context
paper addresses stability tracking control problem underactuated four rotor unmanned flying robot vehicle algorithm design combines adaptive law sliding mode control term deal uncertainties associated flying environment mass inertia aerodynamic force moment vehicle using lyapunov analysis show position orientation tracking errors derivatives bounded bounds made close origin simulation examples quadrotor vehicle given demonstrate effectiveness theoretical development real world application
egocentric allocentric perspective observation hand movements related self differentiation movements observed egocentric viewpoint considered self related movements observed allocentric viewpoint considered belonging someone else correlational studies generally found egocentric perspective induces greater neurophysiological responses larger behavioral effects compared allocentric perspective however recent studies question previous findings reporting greater suppression greater transcranial magnetic stimulation tms induced motor evoked potentials meps observation allocentric compared egocentric movements furthermore self differentiation generally related activity within inferior parietal lobe ipl direct evidence causal functional role ipl self differentiation lacking current study therefore designed investigate influence ipl exerts self differentiation aim measured impact individually adjusted alpha tuned transcranial alternating current stimulation tacs applied ipl suppression hands movement observation egocentric allocentric perspective electroencephalography eeg recorded movement observation immediately tacs results demonstrated tacs decreased reactivity sensorimotor visual regions egocentric allocentric movement observation providing direct evidence causal involvement ipl observation self related hand movement ibro published elsevier ltd rights reserved
simple stereotyped reflexive spinal mediated motor behaviors expressed animals display level flexibility plasticity always recognized discuss several examples coordinated action patterns shown flexible adaptive response sensory feedback focus interlimb intralimb coordination expression two action patterns stepping leg extension response newborn rats well interlimb motor learning also discuss idea spinal cord major site supporting plasticity developing motor system implication research normally occurring sensory stimulation perinatal period influences typical development expression action patterns exploiting developmental plasticity motor system may lead improved strategies promoting recovery function human infants motor disorders wiley periodicals inc dev psychobiol
paper concentrates validation metaheuristic algorithms like backtracking search optimization algorithm bsa fruit fly optimization algorithm ffa tuning optimal pid controller automatic generation control purpose two area reheat interconnected thermal system nonlinearities like generator rate constant grc deadband time delay considered proposed work implemented using matlab simulink various load conditions objective functions metaheuristic algorithms capturing signals various positions proposed model results obtained using two algorithms compared explored elsevier rights reserved
superconducting cavities widely used linear accelerator facilities world challenging low level llrf system stabilize field inside cavities working pulsed mode heavy beam loading strong lorenz force detuning feedback loops implemented llrf system fast responses disturbances cavities enhance feedback performance active compensation lorenz force detuning piezo tuners compensation beam loading feed forward control strongly needed require knowledge cavity parameters quality factor time varying detuning amplitude phase beam disturbance observer based active disturbance rejection control adrc designed superconducting cavities counting lorenz force detuning beam loading disturbances cavities adrc disturbance observer integrated llrf feedback loops speed responses disturbances outputs observer interpreted furtherly identify cavity parameters paper presents algorithm architecture adrc disturbance observer simulation llrf feedback loop disturbance rejection cavity parameter identification applied archived data superconducting cavities operation
study evaluated performance community land surface model clm simulate hydrologic fluxes soil moisture evapotranspiration runoff without remote sensing data assimilation advanced microwave scanning radiometer earth observing system amsr daily ascending descending incorporated clm model using data assimilation technique gldas data used validate amsr data evaluate performance clm simulations amsr data rescaled meet resolution clm model assimilating amsre data clm model improve simulations especially climate transition zones africa east australia south south america southeast asia east north america summer season local ensemble kalman filter lenkf technique improves performance clm model compared directly substituted method improvement surface runoff simulations clm model assimilated amsr data shares similar spatial patterns elsevier rights reserved
wind energy one renewable energy sources trend positive increasing year year technology applied widely several regions world already maturity technology good infrastructure relative cost competitiveness application structural health monitoring shm crucial especially evaluate performance wind turbine real time assessment furthermore smart material shm utilized micro energy harvester well however application shm micro energy harvester wind turbine still premature especially shm embedded bonded strategy several issues highlighted shm material selection wind turbine selection issue micro energy harvester issues discussed compared recent finding review several recommendations suggested future study especially application micro energy harverster
paper present evolution computer programming course univ ersidad nacional colombia unal teaching methodology evolved linear non standardized methodology flexible non linearandstudent centered methodology methodology uses learning platform supports learning process offering students professors custom navigation content material interactive way book chapters exercises videos mareover theplatform open access approximately students university take course term however ourevaluationmethodology evolved static evaluations based papertests online process based computeradaptivetesting cat thatchooses questions ask student assigns student grade according student ability
paper aimed determine structural behavior suspension bridges considering construction stages different soil conditions bosporus suspension bridge connecting europe asia istanbul selected example finite element model bridge constituted using sap program considering existing drawings geometric nonlinearities taken consideration analysis using delta large displacement criterion time dependent material strength steel concrete geometric variations included analysis time dependent material properties considered compressive strength aging shrinkage creep concrete relaxation steel emphases soil condition effect structural behavior suspension bridges hard medium soft soils considered analysis structural behavior bridge different construction stages different soil conditions examined two different finite element analyses without construction stages carried results compared end analyses variation displacement internal forces bending moment axial forces shear forces bridge deck towers given detail also displacement stresses bridge foundation given detail seen analyses differences analyses without construction stages results obtained construction stages bigger stated analysis without construction stages give reliable solutions addition soil condition effect structural behavior bridge thought construction stage analysis using time dependent material properties geometric nonlinearity soil conditions effects considered order obtain realistic structural behavior suspension bridges
development popularization internet computer network widely used various trades fields computer network used frequently daily office management life service example government departments institutions enterprises etc subsequent application internet technology encountered difficulties practice necessary network problems application improve especially network maintenance security risks therefore research analysis maintenance security management network great significance guarantee network operation work paper author first describes concept network maintenance security management analyzes application network security management technology corresponding multi level protection content finally basis pointed current network maintenance security management problems pointed perfect strategy new era network development maintenance provide new ideas
centralized cellular network architecture concept virtualized base station vbs becomes attracting since enables base stations bss share computing resources dynamic manner significantly improve utilization efficiency computing resources paper study computing resource allocation strategy one vbs considering non negligible effect delay introduced switches specifically formulate vbs sum computing rate maximization set optimization problem address problem firstly propose computing resource schedule algorithm namely weight one step greedy osg linear computation complexity considerable performance osg retreat osg algorithm developed improve system performance expense computational complexity simulation results practical setting provided validate proposed two algorithms
aminopropyltriethoxysilane modified titanosilicate prepared alternative developing efficient adsorbents heavy metals obtained material characterized ray diffraction analysis infrared spectroscopy textural analysis scanning electron microscopy adsorption thorium aqueous solutions investigated adsorption isotherms kinetic thermodynamic studies isothermal data found correlated langmuir model maximum sorption capacity experimental data show external diffusion intra particular diffusion significant sorption thorium thermodynamic parameters indicated sorption process physisorption endothermic spontaneous
significant increase system complexity state changes requires effective data driven system identification machine learning algorithm deal control nonlinear systems using streams data collected system data driven controller aims stabilize unknown nonlinear systems modeling uncertainties external disturbances paper proposes novel data driven adaptive control approach backstepping strategy online control unknown nonlinear systems human intervention new meta cognitive fuzzy neural model first introduced construct unknown system dynamics utilize self adaptive tracking error learning parameters determine deletion state data adapt structure parameters controller using information extracted nonstationary data streams subsequently control law constructed based meta cognitive fuzzy neural model rather actual systems backstepping control strategy stability analysis closed loop system presented lyapunov function shows tracking errors converge zero proposed control scheme bound control input considered ensured via stable projection type adaptation laws parameters moreover order save online computation time parameters rule nearest current state updated rules maintain unchanged different existing studies parameters rules updated finally various simulation results inverted pendulum system thrust active magnetic bearing system demonstrate superior performance proposed meta cognitive fuzzy neural control approach
vulnerability segmentation condition plant leaves vulnerable drought induced cavitation stems may act safety valve protect stems hydraulic failure evergreen winter deciduous drought deciduous tree species occur tropical savannas direct studies role vulnerability segmentation stomatal regulation maintaining hydraulic safety trees three leaf phenologies end selected three anacardiaceae tree species occurring chinese savanna evergreen pistacia weintnanniifolia drought deciduous terminthia paniculata winter deciduous lannea coromandelica study inter species differentiation leaf stem hydraulic safety found two deciduous species significantly higher sapwood specific hydraulic conductivity leaf specific hydraulic conductance evergreen species moreover two deciduous species vulnerable stem cavitation evergreen species although drought deciduous species evergreen species drought resistance leaves evergreen species maintained wide hydraulic safety margin hsm stems leaves achieved embolism resistance stems leaves isohydric stomatal control deciduous species limited hsms stems leaves isohydric winter deciduous species anisohydric drought deciduous species difference water potential loss hydraulic conductivity leaves terminal stems poleaf stem positive weinmanniifolia coromandelica whereas paniculata exhibited lack vulnerability segmentation addition differences hydraulic architecture found closely related structural traits leaf mass per area wood density sapwood anatomy overall winter deciduous species exhibits drought avoidance strategy maintains hydraulic safety carbon costly stems sacrificing cheaper vulnerable leaves evergreen species exhibits hydraulic strategy drought tolerance strong stomatal regulation contrast drought deciduous species lacks vulnerability segmentation sheds leaves expense top shoots peak drought study demonstrates even sympatric tree species differ leaf phenology exhibit divergent adaptive hydraulic safety strategies
paper introduces new electronically tunable universal mixed mode biquad filter topology mainly consists single newly introduced modified current conveyor trans conductance amplifier mccta active element two capacitors two resistors passive elements filter topology realize low pass band pass high pass band reject pass filtering responses four different possible modes operation namely current mode voltage mode trans impedance mode tim trans admittance mode tam applying appropriate conditions selection inputs outputs operating circuit need inverted type scaled type current voltage input signal filtering response realization also encouraging sustain feature interactive electronic tunability quality factor well band width independent pole frequency variation single biasing current active element proposed filter simulated pspice software using standard cmos technology offers low incremental active passive sensitivities
memories always accurate people rely variety strategies verify whether events remember really occur several studies examined strategies people tend use none date asked people opt certain strategies others examined extent people beliefs reliability cost different strategies would determine strategy selection subjects described childhood memory suggested strategies might use verify accuracy memory next rated reliability cost strategy likelihood might use reliability cost predicted strategy selection combination two ratings provided even greater predictive value cost significantly influential reliability suggests tendency seek value cheap information reliable information could underlie many real world memory errors elsevier rights reserved
although parenting one commonly studied predictors child problem behavior studies examined parenting multidimensional dynamic construct study investigated different patterns developmental trajectories two parenting dimensions harsh discipline parental warmth person oriented approach examined associations different parenting patterns child externalizing problems callous unemotional traits data drawn combined high risk control normative sample fast track project parent reported observer reported kindergarten grade fit growth mixture models two subgroups identified low decreasing high stable high increasing low increasing majority parents demonstrated low decreasing high increasing pattern prevalence high stable low increasing pattern lowest parenting satisfaction parental depression family socioeconomic status neighborhood safety predicted group memberships jointly defined two dimensions children high stable low increasing pattern showed highest levels externalizing problems grades children low decreasing low increasing pattern showed highest levels callous unemotional traits grade findings demonstrate utility significance person oriented approach measuring parenting multidimensional dynamic construct reveal interplay terms influences child developmental outcomes
background key message world health organization report dementia emphasizes disease top priority public health need improve professional attitudes patients dementia acknowledging workforce dementia care becoming increasingly diverse culturally aims trace whether substantial gaps formal caretakers different cultural groups israeli born jews sabras israeli arabs arabs migrants russia russians regarding stances human dignity autonomy patients dementia well understand meaning gaps design method quantitative analysis utilizing questionnaires filled approximately caretakers different cultural groups working nursing home hospital results nursing homes substantial differences found attitudes human dignity autonomy patients dementia russian arab well sabra caretakers hospital influence ethno culture variable dignity autonomy conclusion contrary past research nursing homes significant differences found certain ethno cultural groups arabs russians regarding stance towards dignity patients dementia arab caretakers hold conception dignity autonomy resonates strongly person centered care outweighs institutional settings well may related fostering virtues elsevier ireland ltd rights reserved
stress mediated electrocaloric effect bitio ferroelectric nanoparticle predicted using phase field simulation combination thermodynamics analysis bitio nanoparticle exhibited positive negative effect applied electric fields negative effect transformed positive effect compressive stress however negative effect appeared across wider temperature range positive effect could even enhanced tensile stress results provide new way tune sign effect enhance coefficient ferroelectric materials elsevier rights reserved
early adverse experiences abuse neglect influence brain development consequently bring forth predisposition toward mental behavioral disorders many authors suggest long term changes functionality hpa axis might involved mediating relationship direction change consequences clarified though early adverse experiences yield stable glucocorticoid hyperfunction long term glucocorticoid hypofunction change functionality associated mental behavioral disorders review summarizes correlative findings illustrates inconsistencies current research literature focuses specific neurochemical milieu accompanying early adverse experiences discusses possible interactions glucocorticoid system oxytocin components serotonergic system basis physiological view novel two pathway model presented according specific early experiences associated characteristic early changes functionality systems result predisposition distinct mental behavioral disorders elsevier ltd rights reserved
persistent deficits social behavior among major negative consequences associated exposure ethanol prenatal development prior work laboratory linked deficits social behavior following moderate prenatal alcohol exposure pae rat functional alterations ventrolateral frontal cortex addition social behaviors regions comprising ventrolateral frontal cortex critical diverse processes ranging orofacial motor movements flexible alteration behavior face changing consequences broader behavioral implications altered ventrolateral frontal cortex function following moderate pae however examined present study evaluated consequences moderate pae social behavior tongue protrusion flexibility variant morris water task required modification well established spatial response pae rats displayed deficits tongue protrusion reduced flexibility spatial domain increased wrestling decreased investigation indicating several behaviors associated ventrolateral frontal cortex function impaired following moderate pae linear discriminant analysis revealed measures wrestling tongue protrusion provided best discrimination pae rats saccharin exposed control rats also evaluated behaviors young adult months older months rats address persistence behavioral deficits adulthood possible interactions early ethanol exposure advancing age behavioral deficits domain persisted well adulthood months however evidence aging enhances effects moderate pae within age ranges studied elsevier rights reserved
purpose study compare personality traits using big five personality taxonomy alcohol consumption classical heavy metal musicians also compared personality traits classical heavy metal musicians norms croatian population data alcohol consumption representative sample general croatian population participants study men playing either classical heavy metal music personality measured ipip personality questionnaire participants answered several questions alcohol consumption found significant differences personality traits classical heavy metal musicians classical heavy metal musicians differed significantly personality norms higher scores extraversion agreeableness especially intellect belonging heavy metal musicians group associated consuming alcohol often also frequency alcohol consumption statistically higher heavy metal musicians general population
nde nuclear distribution element also known nude ndel nde like also known nudel mammalian homologues fungus nude gene important least partially overlapping roles brain development large number studies describe various properties functions proteins many directly compare similarities differences nde ndel although sharing high degree structural similarity multiple common cellular roles protein presents several distinct features justify parallel also unique functions notably proteins key binding partners dynein lis disc impact neurodevelopmental psychiatric illnesses implicated schizophrenia genetic functional evidence nde also strongly implicated microcephaly well neurodevelopmental psychiatric conditions copy number variation ndel possesses oligopeptidase activity unique potential biomarker schizophrenia review aim give comprehensive overview various cellular roles proteins bottom manner biochemistry protein protein interactions molecular level consequences neuronal differentiation ultimately importance correct cortical development direct consequences pathophysiology neurodevelopmental mental illness
department mechanical materials engineering faculty engineering built environment offers two master programs namely master science industrial technology management master engineering manufacturing systems using executive part time mode practicing engineering managers manufacturing industry aim programs provide higher degree learning opportunity engineering managers advance knowledge manufacturing processes industrial technology management program high demand potential students due rapid technological advancement stiff international business competition selling products services new competitiveness business environment made crucial engineering managers enhance technical managerial skills performing daily tasks programs first offered academic session paper authors would like present analysis customer students feedbacks academic session respect programs relevancy appropriateness main aims presenting paper identify programs strengths weaknesses respect course contents mode delivery done authors would like use students feedbacks update improve course contents mode delivery program par well established universities results study show programs still many weaknesses terms course contents mode delivery thus need attention department alleviate shortcomings published elsevier ltd selection peer reviewed responsibility ukm teaching learning congress
paper propose approach speed reconstruction city village town sanriku coast areas unprecedented damages great east japan earthquake occurred march two policies approach one build models reconstruction plans order visualize reconstruction plans develop human resources build models reconstruction plans setting training courses teach modeling method another people assist reconstruction accelerate whole recovery professional education teaching contents involve cad computer aided design computer graphics since constructed models involve cad topographic map aerial photographs geography attribute information road river rail way easy residents understand whole reconstruction plans fact models definitely effective residents briefing confirmation urban planning
objectives objective study describe factors influence ability state medicaid agencies report centers medicare medicaid services cms core set children health care quality measures child core set methods conducted multiple case study four high performing states participating children health insurance program reauthorization act chipra quality demonstration grant program illinois maine pennsylvania oregon cases purposively selected diverse measurement approaches used data including interviews semiannual grant progress reports annual public reports child core set measures followed yin multiple case study methodology describe state increased number measures reported cms results four states increased number child core set measures reported cms grant period took different approach reporting depending available technical organizational behavioral inputs state reporting capacity influenced state medicaid data availability ability link state data systems past experience quality measurement staff time technical expertise demand measures factors enhanced chipra quality demonstration grant funding federal capacity building activities hypothesized conceptual framework states made progress reporting child core set since conclusion financial support investment state data systems organizational factors states overcome challenges reporting child core set measures
background childhood subthreshold manic symptoms may represent state developmental vulnerability bipolar disorder may also associated adverse psychiatric outcomes test hypothesis examined structure predictive value childhood subthreshold manic symptoms common psychiatric disorders presenting early adulthood methods subthreshold manic symptoms age years lifetime clinical outcomes age years ascertained tracking adolescents individual lives survey trails prospective dutch community cohort used latent class analysis identify subthreshold manic symptom profiles baseline association class membership subsequent clinical diagnoses comprising mania hypomania depressive anxiety substance abuse disorders determined using cox proportional hazard ratio models results age years identified normative mildly symptomatic highly symptomatic class referenced normative class sex age adjusted risk new onset age years significantly increased mildly highly symptomatic classes estimates remained significant adjustments cognitive family function parental socioeconomic status parental psychiatric morbidity comorbid disorders baseline value linear trend across classes class membership show significant associations incident depressive anxiety substance abuse disorders fully adjusted regression models limitations period risk adult onset extends beyond observational period study conclusions elevated childhood subthreshold manic symptoms associated increased risk early adulthood therefore potentially useful phenotype early identification risk individuals
background present study mainly focussed following parameters thyroid disease burden pregnant females hospital types thyroid disorders pregnancy complications pregnancy delivery thyroid dysfunction whether routine screening thyroid disorders pregnancy advisable materials methods pregnant women first trimester pregnancy randomly registered study department obstetrics gynaecology govt medical college hospital thrissur kerala getting ethical clearance informed consent patients data collected per proforma interview patients first trimester pregnancy free free tsh levels necessary thyroid antibody levels checked results patients followed till delivery immediate postpartum period results analysed prevalence hypothyroidism hyperthyroidism study adverse maternal effects hypothyroid group seen preeclampsia significant adverse foetal outcomes also noted hypothyroid group intrauterine growth restriction significant conclusion prevalence thyroid disorders high study hence avoid associated maternal foetal consequences routine screening thyroid function pregnancy recommended
previous work revealed secure parental attachment promotes prosocial behaviors underlying mechanism less commonly explored drawing upon bowlby attachment theory current study examined role self control link parental attachment prosocial behaviors six hundred seven chinese adolescents participated study completing measures assessed parental attachment self control prosocial behaviors results showed secure maternal attachment rather paternal attachment directly related prosocial behaviors total sample girls importantly self control mediated links maternal paternal attachment prosocial behaviors across sex conclusion self control partly addresses individuals report securely attached parents engage prosocial behaviors elsevier ltd rights reserved
objective examine existence selection bias first years minnesota senior health options msho demonstration estimate msho effects medical services utilization adjusting selection bias data sources monthly dual eligibility data msho encounter data march december medicaid encounter data january december minnesota department human services medicare fee service claims data january december centers medicare medicaid services study design quasi experimental design comparing utilization msho control groups multiple econometric statistical models estimated time invariant time varying covariates principal findings favorable msho selection found nursing home community populations selection bias substantially affect findings enrollment msho year reduced inpatient hospital admissions days emergency room physician visits residents lowered physician visits community residents conclusions favorable selection first years msho program enrollment msho reduced several types utilization group physician visits community enrollees
objective eyes depressed world may appear dull gray visual contrast sensitivity recently reported lower depressed patients compared healthy controls aimed examine consistency finding explore underlying retinal electrophysiology methods twenty subjects major depressive disorder matched healthy controls studied pattern electroretinogram perg subjective visual contrast test used assess visual contrast sensitivity full field electroretinography fferg additionally used assess retinal neurophysiology depression diagnosed based diagnostic statistical manual mental disorders dsm depression severity measured using standard psychometric scales results visual contrast sensitivity significantly lower depressed patients compared controls based landolt visual contrast test difference found groups using perg fferg greater severity depressive symptoms correlated poorer visual contrast sensitivity conclusions depressed subjects reduced visual contrast discrimination performance finding could consistently determined using perg neurobiological link major depressive disorder visual contrast sensitivity warrants investigation elsevier inc rights reserved
purpose small medium sized enterprises smes form significant portion many economies vulnerable impact extreme weather events ewes particular importance construction industry overarching majority construction companies smes account majority employment income generation within industry previous research identified construction smes worst affected ewes paper aims discuss issues design methodology approach given recent occurrences ewes predictions suggesting increases intensity frequency ewes future improving resilience construction smes vital achieving resilient construction industry conceptual framework first developed populated expanded based empirical evidence positioned within pragmatic research philosophy case study research strategy adopted overall research strategy undertaking investigation findings based findings two depth case studies construction smes framework developed represent ewe resilience construction smes resilience seen collective effect vulnerability coping strategies coping capacities smes characteristics ewe wider economic climate originality value paper provides original contribution towards overarching agenda resilience smes policy making area ewe risk management presenting novel conceptual framework depicting resilience medium sized construction companies
background pressure ulcers pus associated high mortality morbidity health care costs addition costly prus cause pain suffering infection lower quality life extended hospital stay even death although several nursing interventions advocated literature paucity research constitutes effective nursing intervention objectives determine efficacy multidisciplinary intervention assess component intervention predictive decreasing prevalence hospital acquired pressure ulcers hapu tertiary setting lebanon design evaluation prospective research design utilized data intervention sample consisted patients admitted hospital january april results prevalence hapu significantly reduced sensitivity braden scale predicting hapu specificity logistic multiple regression equation found two factors significantly predicted development hapu skin care braden scores conclusion multidisciplinary approach effective decreasing prevalence hapus skin care management significant predictor pus alert nurses cost effectiveness intervention lower braden scores also predictive hapus published elsevier inc
globalization trend affected tertiary education sector resulting increased flow students academics across borders economic pressures universities emergence new technologies spurred creation new systems engineering education recent advances computer graphics exposed great potential education levels virtual reality promising technology aims assist students visualization concepts provide immediate graphical feedback learning process article presents modular interactive teaching package called virtual learning system vls used people little prior computer experience vls provides comprehensive conductive yet dynamic interactive environment incorporated various courses field mechanical manufacturing engineering evaluation learning process developed system done laboratory reports lab quizzes questionnaires implemented tutorial monitoring application wiley periodicals inc comput appl eng educ view article online wileyonlinelibrary com doi cae
background self harm associated increased suicide risk constitutes major challenge adolescent mental healthcare current study examined association different aspects adolescent health risk later self harm requiring hospital admission methods linked baseline information year old participants norwegian young hunt study patient records self harm hospitalisation years follow used cox regression estimate risk factor hazard ratios results eighty nine persons female admitted hospital self harm intoxication self poisoning frequent method mental anxiety depression loneliness bullied somatic epilepsy migraine health issues associated fourfold increased risk self harm related hospital admission conclusions several health issues adolescence markedly increased risk later self harm hospitalisation current findings incorporated strive reduce self harming attempted suicides among young people
tobacco smoking single important modifiable factor increased morbidity premature mortality numerous factorsincluding genetics personality environmentaffect development persistence tobacco addiction knowledge regarding factors could improve smoking cessation rates study compared personality traits never former current smokers using five factor model personality country turbulent smoking reduction process cross sectional study polish adults completed revised neuroticism extraversion openness personality inventory results showed current smokers scores extraversion one five global dimensions personality higher relative never smokers neuroticism openness experience agreeableness conscientiousness differ significantly according smoking status facet analysis described dimension detail showed current smokers activity excitement seeking facets extraversion scores higher relative never former smokers turn current smokers dutifulness deliberation facets conscientiousness scores lower found former never smokers never smokers scored highest self consciousness facet neuroticism compliance component agreeableness study conducted among polish individuals showed variation personality traits according smoking status however variation differed reported countries efforts reduce smoking begun earlier relative poland knowledge regarding personality traits could useful designing smoking prevention cessation programs tailored individuals needs
introduction individuals rate opposite sex faces attractive consuming primed alcohol however traits intelligence likeability examined might vary function information one drinking habits expected social drinkers rated positively heavy drinkers abstainers recovering alcoholics hypothesized faces similar drinking habits participants would rated appealing methods five hundred ninety four undergraduates viewed opposite sex faces randomly paired drinking information rated face perceived appeal results hierarchical linear models revealed social drinkers rated appealing expected unexpectedly recovering alcoholics rated next appealing followed abstainers heavy drinkers interaction drinker type participants drinking predicting ratings indicated heavier participant drinks favorably rated heavy drinkers compared types drinkers thus expected ratings varied function participants drinking however ratings vary function participants alcohol related problems conclusions findings support hypotheses social drinkers generally perceived appealing compared drinker types ratings tended influenced participants drinking individuals prototypes norms regarding drinking may influence perceive others others drinking habits known might especially important consider heavy drinkers may seek others drink similarly could reinforce problematic drinking published elsevier ltd
aim study investigate water compartments patients rheumatoid arthritis acute inflammatory episodes infection stimulate water retention chiefly implemented sympathetic nervous system sns hypothalamic pituitary adrenal hpa axis important compensatory mechanism due expected water loss sweating etc since sns hpa axis activated inflammation might accompanied water retention using bioimpedance analysis body composition investigated controls treatment patients january december group patients tested days intensified therapy levels pro atrial natriuretic peptide proanp expression atrial natriuretic peptide synovial tissue investigated controls patients extracellular water higher patients controls mean sem total body water plasma levels proanp higher controls patients expressed anp synovial tissue synovial fluid levels synovial tissue superfusate levels much lower plasma levels indicating systemic origin systolic diastolic blood pressure higher patients controls extracellular water levels change patients despite days intensified treatment study demonstrates signs intravascular overload patients short term intensification anti inflammatory therapy induced change longer lasting imprinting water retention indicating requirement additional treatment study direct attention area volume overload
measuring fracture strength brittle materials often difficult alignment load test specimen critical axis misalignment load produce fracture undesired mode report describes several micrometer scale devices load cell fabricated simultaneously fracture mechanics specimen precise alignment assured devices utilize residual stresses contained within materials deposited onto substrates create loading forces determine fracture strength devices passive meaning fracture results obtained immediately upon fabrication external loading required stress concentrations generated notches fracture strength determined critical stress required failure variety devices fabricated materials interest microelectromechanical systems devices including polysilicon silicon nitride aluminum tensile compressive residual stresses
motivated repeated spikes crashes previous decades investigate whether heavily financialized market crude oil driven speculative bubbles theoretical modeling draw convenience yield approach order approximate fundamental value oil price separate oil price fundamental bubble component expressing standard present value oil price model state space form introduce two markov regimes state space representation order distinguish two distinct phases bubble process namely one oil price bubble stable process one bubble explodes estimate entire markov switching state space specification using econometrically robust bayesian markov chain monte carlo mcmc methodology based inferential techniques designed statistically separating markov regimes bubble process find robust evidence existence speculative bubbles recent oil price dynamics elsevier rights reserved
generating associations important cognitive tasks including language acquisition creative problem solving remains open question brain represents processes associations remote associates test rat task originally used creativity research heavily dependent generating associations search solutions individual rat problems work present model solves test compared earlier modeling work rat hybrid non developmental model implemented spiking neural network means neural engineering framework nef demonstrating possible spiking neurons organized store employed representations manipulate particular model shows distributed representations support sophisticated linguistic processing model validated human behavioral data including typical length response sequences similarity relationships produced responses data suggest two cognitive processes involved solving rat one process generates potential responses second process filters responses
alterations amygdala activity apparent women report history early life stress els diagnosed chronic pain disorders chronic stress adulthood induces visceral hypersensitivity alterations glucocorticoid receptor corticotropin releasing factor crf expression within central amygdala cea hypothesized unpredictable els previously shown induce visceral hypersensitivity adult female rats alters crf expression cea neonatal els visceral sensitivity crf gene expression quantified adult female rats unpredictable els adult female rats exhibited visceral hypersensitivity increased expression crf cea predictable els adult female rats demonstrated normosensitive behavioral pain responses upregulation crf cea els paradigms visceral sensitivity gene expression within cea unaffected adult male rats role crf modulating visceral sensitivity adult female rats els investigated using oligodeoxynucleotide sequences targeted cea knockdown crf knockdown increased visceral sensitivity rats revealed exaggerated visceral hypersensitivity females history predictable unpredictable els compared controls knockdown crf expression antagonism crfr cea attenuated visceral hypersensitivity unpredictable els study highlights shift crf regulation within cea els underlies development visceral hypersensitivity adulthood
integrate economic behavioral social support perspectives provide theoretical account hiv aids experience india given complex nuances current appearance infection nation one particular theoretical interpretation might suffice provide holistic comprehension aids situation nation conflict perspective highlights class effects poverty explaining spread infection behavioral framework although allied marxian postulate moves beyond economic determinism explains spread infection among marginal social groups india hijra population men sex men social support model outlines social attitudes towards marginalized impedes health intervention risk assessment disclosure health status theoretical tradition provides cognitive link intertwined speculating agency emerge middle social obstacles discuss marxian notions class consciousness goffman idea stigmatized educating nonstigmatized bourdieu concept social capital correspond preliminary coalescence institutional stages collective movement raising consciousness hiv aids developing context transformative studies institute rights reserved
weight efficiency conflicting top requirements kind mobile applications electrical machines utilizing design freedom novel machine design based slotless air gap winding providing high torque efficient cooling paper presents design optimization approach allows precise fast design type machine design speed achieved building simplified parametric model electrical machine combines well nonlinear optimization formulation design problem machine mass losses balanced find pareto optimal design set additional design requirements treated via constraints parametric machine model built upon numerical finite elements method analysis magnetic flux density air gap ansys maxwell used formulate parametric fourier series based models flux acting phase flux acting six step commutated winding effective flux useful define machine torque constant except numerical optimization procedure model design equations formulated analytically exploiting maple symbolic computation features thus simplifying analysis speeding design finally optimal motor design study inch rim wheel hub drive presented range tradeoff demands weight efficiency delivering required torque nominal speed shown
paper describes efficient parallel algorithm uses many core gpus automatically deriving unique input output sequences uios finite state machines proposed algorithm uses global scope gpu global memory coalesced memory access minimises transfer cpu gpu memory results experiments indicate proposed method yields considerably better results compared single core uio construction algorithm algorithm scalable multiple gpus added system approach handle fsms whose size larger memory available single gpu
pathogenic fungi developed many strategies evade host immune system multiple escape mechanisms appear function together inhibit attack various stages adaptive innate immune response thus entering host pathogens fight overcome immune system allow survival colonization spread different sites infection consequently establishment successful infectious process closely related ability pathogen modulate attack immune system strategies employed subvert exploit immune system shared among different species fungi review summarize main strategies employed immune evasion major pathogenic fungi
introduction facial fractures straightforward closed nasal reductions complex pan facial fractures commonly encountered plastic surgical community however little discussed literature regarding outcomes facial fractures relating contributing factors aim evaluate battery independent variables order identify factors correlate suboptimal outcomes patients undergone facial fracture surgery methods data use agreement american college surgeons public use files nsqip patients involving repair facial fractures current procedural terminology codes inclusive queried outcomes examined included wound dehiscence superficial surgical site infection deep surgical site infection readmission open wound wound infection return operating room results facial fracture patients national surgical quality improvement program datasets thirteen perioperative risk factors patient comorbidities evaluated correlation outcomes outcomes evaluated open wound wound infection prevalent outcome factors statistically significant presence open wound wound infection american society anesthesiology classification presence bleeding disorder emergency patient chronic alcohol use chronic steroid use discussion several factors correlated presence open wound wound infection however variables diabetes active tobacco use often thought contribute wound infections shown statistically nonsignificant although study limited observational nature data may indicate change perception factors correlated wound infections
storm water management model swmm effective tool simulating floods urban areas seldom applied river systems study geographic information system gis based swmm model developed authenticate model viability streamflow simulator modeling floods brahmani river delta model set using shuttle radar topography mission digital elevation model srtm dem national remote sensing centre landuse land cover nrsc soil national bureau soil survey nbss indian meteorological department imd meteorological forcings tuned using india water resource information system india wris streamflow data calibration validation model carried monthly time scale using monte carlo based auto calibration technique addition daily basis calibration validation carried nash sutcliffe efficiency percent bias values found lie respectively moreover root mean square error observations standard deviation ratio rsr values almost close zero indicating reasonably good model performance subsequently model reasonably predicted maximum flow regulated prevent possible inundation downstream areas developed model thus employed effective flood modeling tool
traditional fluid structure interaction techniques based arbitrary lagrangian eulerian method strong coupling method used solve fundamental discretized equations discretization resulting nonlinear systems solved using iterative method leading set linear subsystems resulting linear subsystem matrices sparse non symmetric indefinite small zero diagonal entries small pivots matrices may render incomplete factorization unstable inaccurate improve paper proposes approach used together stabilization offers additional feature used gain advantage parallelization published elsevier ltd
chronic watery diarrhea poses diagnostic therapeutic challenge often disabling condition patients although acute diarrhea likely caused infection causes chronic diarrhea weeks duration elusive review pathophysiology diagnosis treatment chronic diarrhea drawing recent insights molecular mechanisms intestinal epithelial transport barrier function discuss diarrhea result decrease luminal solute absorption increase secretion well derangements barrier properties also describe various extraepithelial factors activate diarrheal mechanisms finally clinical evaluation tests used assessment patients presenting chronic diarrhea reviewed algorithm guiding therapeutic decisions pharmacotherapy presented
part two part life cycle efficiency greenhouse gas emission analysis various automotive fuels indian context paper presents first part tank wheel analysis various fuel powertrain configurations subcompact passenger car tank wheel analysis applied fuel powertrain configurations using fuels gasoline diesel compressed natural gas liquefied petroleum gas hydrogen various conventional hybrid electric powertrains gasoline equivalent fuel economy carbon dioxide emission results individual fuel powertrain configuration evaluated compared found split hybrid configuration best among hybrids leads fuel economy improvement carbon dioxide emissions reduction indian drive cycle engine efficiency engine time regenerative braking energy assessment done evaluate causes higher energy efficiency hybrid electric vehicles hybridization increases average engine efficiency includes energy recovered wheel regenerative braking drive cycle overall tank wheel energy use efficiency results evaluated fuel powertrain configurations show battery electric vehicle fuel cell vehicles diesel hybrids near long term energy efficient vehicle configurations elsevier ltd rights reserved
succession archaeological units notarchirico offers technical environmental arguments aimed characterization variability european ancient palaeolithic analysis shows presence distinctive features within acheulean assemblage besides presence handaxes hominins used flint limestone site lithological analysis shows predominance raw materials every unit partial selective exploitation unit traditionally associated called mode knapper principally intended produce sharp convergence sharps choppers bifacial tools units flaking prevails sporadic shaping presence cores polyhedral forms extreme dimensional reduction objects main technical features associated core flake assemblage presence absence handaxes element variability presence micro tools technical elements represent technological innovations lower pleistocene assemblages common many italian sites called mode transition traditional idea acheulean uniform entity characterized presence handaxes seem valid published elsevier ltd
background role pathogen specific cellular immune responses eliciting pathogen development post infectious chronic fatigue syndrome cfs known studies difficult perform aim study evaluate specific anti giardia cellular immunity cases developed cfs giardia infection compared cases recovered well patients reporting chronic fatigue questionnaire study three years giardia outbreak clinically evaluated five years outbreak grouped according fukuda criteria cfs idiopathic chronic fatigue giardia specific immune responses evaluated patients proliferation assay cell activation cytokine release analysis giardia exposed non fatigued individuals healthy unexposed individuals recruited controls results patients clinically classified cfs idiopathic chronic fatigue fatigue causes recovered fatigue statistically significant antigen specific differences giardia exposed groups unexposed controls however find differences giardia exposed fatigue classification groups regard cell activation proliferation cytokine levels days cultured pbmcs interestingly scdl increased patients cfs persons fatigue giardia infection compared non fatigued group correlated well fatigue levels time sampling conclusion data show antigen specific cellular immune responses groups previously exposed giardia increased scdl fatigued patients
introduction combining dipeptidyl peptidase inhibitor sodium glucose cotransporter type inhibitor attractive option treat hyperglycaemia type diabetes areas covered saxagliptin plus dapagliflozin combination carefully analysed focusing pharmacokinetic properties pharmacodynamics data results randomised controlled trials dual combination versus either monotherapy sequential therapy saxagliptin added dapagliflozin dapagliflozin added saxagliptin expert opinion pharmacokinetic findings demonstrate absence drug drug interaction bioequivalence fdc compared separated tablets pharmacodynamic observations confirm complementary mode action two agents dual saxagliptin dapagliflozin therapy potent either monotherapy may used initial combination although approach remains debatable probably reserved case high glycated hemoglobin stepwise strategy according personalized approach developed saxagliptin dapagliflozin fdc may simplify anti hyperglycemic therapy improve drug compliance
background moderate severe psoriasis often requires treatment systemic agents many immunosuppressive properties could increase cancer risk including nonmelanoma skin cancer nmsc objective sought estimate overall malignancy rate excluding nmsc nmsc rate among patients systemically treated psoriasis methods identified cohort adult kaiser permanente northern california health plan members psoriasis diagnosed treated least systemic antipsoriatic agent categorized ever biologic nonbiologic users malignancy rates calculated per person years follow confidence intervals crude confounder adjusted hazard ratios ahrs calculated using cox regression results biologic exposed members treated tnf alfa inhibitors overall incident cancer rates comparable ever biologic compared nonbiologic users ahr nmsc rates higher among individuals ever exposed biologic ahr largely driven increased cutaneous squamous cell carcinoma risk ahr limitations information available disease severity conclusion found increased incidence cutaneous squamous cell carcinoma among patients systemically treated psoriasis ever exposed biologics majority tnf alfa inhibitors increased skin cancer surveillance population may warranted
paper presents aspects related water pollution heavy metals tarnita mining area cessation mining activity impact heavy metals waters important metals negative impact human health aquatic ecosystems research data showed even mining activities area suspended sterile still pollutes soil water
electric vehicles enhance positive contribution energy economy smart integration electrical network appropriate design use oriented energy storage system design consequently integrated vehicle structure driven predicted use regard charging potential operational mission frequency opportunistic charging daily mission factor considered appropriate sizing board energy storage design strategic location charging ports interactive vehicle infrastructure communication easiness charging procedure taken reference appropriate sizing storage system terms energy availability weight related parameters impacting relevant energy life cycle figure evolution technology concept magnetic flux application contactless energy transfer use resonant circuits brought new technical solutions offer flexible user friendly vehicle infrastructure interface various modes operation electric vehicles static dynamic wireless dynamic power transfer offer means reduce significantly board energy storage system requirements trade opportunities considered various elements vehicle infrastructure size technical economical grid side management well grid vehicle interaction multi aspect matter addressed european projects fabric connect
present study investigates possibility using blended class fly ash residual rice husk ash rha production green building bricks application densified mixture design algorithm dmda order provide new use solid waste materials study uses unground rice husk ash urha partial fine aggregate substitution studied cementitious mixtures solid bricks xxmm size prepared forming pressure mpa curing temperature degrees relative humidity tests assessed compressive strength flexural strength bulk density void volume water absorption test results showed brick samples demonstrated excellent properties compressive strength flexural strength ranged respectively mpa mpa additionally urha content values water absorption void volume ranged respectively values conformed well requirements vietnamese codes also demonstrated great potential using blended rha producing green building bricks
since initial visions proposed smartdust project fifteen years ago wireless sensor networks seen tremendous development leading realization internet things iot today large variety hardware software choose easy set use even though increasing number real world applications employ large deployments iot devices wireless nature communication combination low end capabilities devices raises security privacy issues properly addressed considering also sensor node brands different capabilities providing single solution challenging paper adopt elliptic curve cryptography ecc attractive alternative conventional public key cryptography rsa ecc ideal candidate implementation constrained devices major computational resources speed memory limited low power wireless communication protocols employed attains security levels traditional cryptosystems using smaller parameter sizes provide generic implementation ecc runs different host operating systems contiki tinyos isenseos scatterweb arduino furthermore runs smartphone platforms android iphone also linux based systems raspberrypi implementation contain platform specific specializations allowing single implementation run natively heterogeneous networks look smart parking application domain provide solution protects privacy users totally avoiding exchange confidential information also show protect user privacy adapting tool zero knowledge proofs zkp ecc implementation study performance system real world outdoor iot testbed analyze execution time network overhead available hardware platform code available open source software used developers wish achieve certain levels security privacy applications elsevier rights reserved
purpose human thyroid development complex still unexplained process thyroid hemiagenesis congenital anomaly one thyroid lobes fails develop majority patients thyroid hemiagenesis genetic background remains unknown aim study search novel genetic contributors etiology thyroid hemiagenesis methods cohort sporadic patients diagnosed thyroid hemiagenesis one three generation family subjected comprehensive genomic examination initially targeted screening associated transcription factors known linked thyroid development performed next step genomic examinations applied using high resolution microarrays whereas thyroid hemiagenesis family additionally whole exome sequencing performed results screening transcription factors revealed causative mutations studied cohort genomic examinations revealed presence four recurrent defects three deletions one duplication affecting highly conservative proteasome genes psma psma psmd thyroid hemiagenesis family splice site mutation proteasome gene psmd cdna found affected mother daughter conclusions results shed new light etiology thyroid hemiagenesis far suspected linked mutations genes directly involved thyroid development demonstrated first time genomic alterations proteasome associated genes occur patients presenting developmental anomaly
paper symbolic computation lie symmetry analysis painleve test conservation laws similarity solutions generalized dimensional variable coefficients nizhnik novikov veselov vcnnv equation studied firstly derive group classifications corresponding symmetry reductions via lie group method new variable separation solutions lie symmetry properties discussed integrable conditions system determined via painleve analysis last new infinite time dependent conservation laws derived base new conservation theorem proved ibragimov elsevier inc rights reserved
shared approach decision making framework suggested chronic disease management especially multiple treatment options exist shared decision making sdm requires physician patients actively engaged decision making process including information exchange expressing treatment preferences well agreement final treatment decision although sdm appears well supported patients practitioners policymakers alike current challenge determine best make sdm reality everyday clinical practice within context asthma adherence rates poor linked outcomes reduced asthma control increased symptoms healthcare expenditures lower patient quality life suggested sdm improve treatment adherence ignoring patients personal goals preferences may result reduced rates adherence furthermore understanding predictors poor treatment adherence necessary step toward developing effective strategies improve patient reported clinically important outcomes describe shared approach treatment decision making asthma potential effective tool improving adherence associated clinical patient related outcomes addition explore insights reasons sdm implemented routine clinical practice
objective first explore item pools developed measure physical home environment pre school children assess psychometric properties item pools second explore associations environment vegetable consumption among norwegian year olds design data collected three steps parental web based questionnaire assessing child vegetable intake factors potentially influencing child vegetable consumption direct observation children fruit berry vegetable intakes two meals one day kindergarten iii parental web based recall setting target group study pre school children born attending public private kindergartens counties vestfold buskerud norway subjects total children participated results principal component analysis thirteen item pool assessing availability accessibility resulted two factors labelled availability home accessibility home eight item pool assessing barriers resulted two factors labelled serving barriers purchase barriers psychometric properties factors satisfactory linear regression associations vegetable intake factors showed generally positive associations availability home accessibility home negative associations serving barriers conclusions age group far understudied need comparable studies findings highlight importance targeting physical home environment pre school children future interventions important modifiable factors promote hinder vegetable consumption environment
last fifteen years europe involved major development photovoltaic solar energy kyoto protocol requirements european union directives promote use renewable energy sources res together environmental policies introduced development use alternative energies generated large number market opportunities sector differences application energy policies caused significant imbalances electricity systems distortion electricity prices main concern governments define support schemes used combine profitable manner aim paper provide comparative cost effectiveness assessment using feed tariffs fit net metering schemes representative countries authors developed economic model evaluate profitability projects combining support schemes results show circumstances solar energy economically profitable also kind systems locations minimum levels tariff prices specific combination support schemes promoted
order explore early detection mycotoxins wheat three standardized approaches fusarium disease severity pcr assays fusarium spp identification mycotoxin quantification novel untargeted metabolomics strategy jointly assessed first phase research standardized approaches able quantify mycotoxins identify fusarium spp uhplc qtof metabolic fingerprinting method developed investigate plant pathogen cross talk time chemometrics analysis demonstrated powerful tool order distinguish low strong infection levels combining results cross talk plant pathogen related early detection mycotoxins discovered rapid response fungal infection overexpression phosphatidic acids discovered contrast infection became stronger increase oxylipins diacylglycerols revealed elsevier ltd rights reserved
computational fluid dynamics cfd simulation method based navier stokes equation arbitrary lagrangian eulerian ale method presented analyze grooved slipper performance piston pump moving domain grooved slipper transformed fixed reference domain ale method makes convenient take effects rotate speed body force temperature oil viscosity account geometric model express complex structure covers orifice piston slipper vented groove oil film constructed corresponding different oil film thicknesses calculated light hydrostatic equilibrium theory boundary conditions set simulations conducted comsol analyze pump characteristics effects geometry groove width radius orifice size characteristics furthermore mechanics hydraulics analyses employed validate cfd model excellent agreement simulation analytical results simulation results show sealing land radius orifice size groove width dramatically affect slipper behavior optimum tradeoff among factors conducive optimizing pump design authors production hosting elsevier ltd behalf chinese society aeronautics astronautics
background gastrointestinal tract cancers account significant proportion national cancer burden aim sought explore patient hospital level determinants palliative care utilization among patients hospitalized metastatic gastrointestinal tract cancers using national database methods analysis national inpatient sample performed international classification diseases ninth revision codes used identify hospital discharges associated metastatic digestive tract cancers patient hospital covariates inclusion logistic regression model total charges length stay analyzed linear regression model results compared males females likely receive inpatient palliative care adjusted odds ratio difference seen white asian patients adjusted native americans patients adjusted however relative white patients african americans adjusted hispanics adjusted significantly higher odds inpatient palliative care medicare patients least likely receive palliative care compared medicaid commercial payers length stay hospitalizations longer african americans asians native americans compared white patients difference seen total charges compared white african american patients conversely total charges higher hispanics asians relative white patients conclusion gender racial differences exist utilization inpatient palliative care among patients hospitalized metastatic gastrointestinal tract cancers
incentivizing development deployment renewable energy sources res also low carbon technologies lct successful way promoting new technologies creating feasible investment case making competitive traditional energy sources although different incentive mechanisms exist feed tariffs shown best model accelerating lct development guaranteeing producers preferential prices produced electricity period time enabling access power network sell inject produced electricity due benefits feed tariff models common model stimulating res integration southeast europe paper reviews current state preferential tariffs res countries southeast europe countries already significant installed res capacity others still planning stage review shows amount installed capacity specific technology strong impact support future projects technology comprehensive review legislative development supporting res well technologies preferred different countries region supported feasibility assessment investing res using example two different technology projects wind photovoltaic analysing impact current tariffs return investment country region
background despite public health campaigns encouraging women take daily folic acid supplement proportion reproductive age women united states comply recommendation less optimal objective analysis identify predictors preconceptional folic acid containing supplement use define subgroups women may benefit targeted folic acid campaigns methods study included mothers live born infants control population national birth defects prevention study logistic regression analyses used identify predictors preconceptional folic acid supplementation classification regression tree cart analysis used define subgroups women different patterns preconceptional folic acid supplementation results race ethnicity education age delivery nativity employment income number dependents smoking birth control use significantly associated preconceptional folic acid containing supplement use based cart analysis education race ethnicity age distinguishing factors women different preconceptional supplementation patterns non white women years college women supplemented folic acid conclusion results demonstrate need continued efforts increase folic acid supplementation among reproductive aged women however success efforts may improved maternal characteristics education race ethnicity age considered development future interventions wiley periodicals inc
detecting early enough anomalous behavior technical systems facilitates cost savings thanks avoiding system downtimes guiding maintenance improving performance novel framework proposed paper processes event streams originating system monitoring anomaly detection purposes therefore statistical models characterizing normal behavior monitored system learned events instead one coarse normal model operational states proposed framework contains mechanism automatically detecting different conditions systemallowing fine tuned models every condition performance framework demonstrated means real world application log files large scale printing machine analyzed anomalies
ever increasing accessibility different multimedia contents real time difficult users identify proper resources vast number choices utilizing user context consuming diverse multimedia contents identify different personal preferences settings however need reinforce recommendation process systematic way context adaptive information contributions paper twofold first propose framework called recam enables collection contextual information delivery resulted recommendation adapting user environment using ambient intelligent ami interfaces second propose recommendation model establishes bridge multimedia resources user joint preferences detected contextual information hence obtain comprehensive view user context well provide personalized environment deliver feedback demonstrate feasibility recam two prototypes applications use contextual information recommendations offline experiment conducted shows improvement delivering personalized recommendations based user context two real world datasets
background cow milk hen egg wheat staple foods typical western diet despite ubiquity foods impact staple food allergy health related quality life hrql amongst adolescents incompletely understood aims study make use swedish version europrevall disease specific food allergy quality life questionnaire teenager form faqlq investigate association objectively diagnosed staple food allergy hrql amongst adolescents methods cross sectional study adolescents aged years boys objectively diagnosed allergy staple foods cow milk hen egg wheat living stockholm sweden included adolescents completed faqlq corresponding scale best hrql worst hrql overall hrql domain specific hrql established adolescents also reported symptoms adrenaline auto injector aai prescription presence food allergies history anaphylaxis defined among reporting difficulty breathing inability stand collapse loss consciousness clinically different hrql set mean difference results overall mean hrql poorer average mean domain risk accidental exposure significantly associated clinically better hrql domain allergen avoidance dietary restrictions mean difference girls clinically worse statistically significantly different mean hrql boys mean difference hrql tended worse amongst allergies three foods aai prescription number types symptoms including history anaphylaxis associated worse hrql conclusions ascertained via food allergy specific questionnaire adolescents staple food allergy report poorer average hrql specifically relation emerging independence need support girls clinically worse hrql boys number type previous symptoms history anaphylaxis associated worse hrql
increase fathers involvement childrearing particularly beyond infancy warrants research exploring factors influencing quality child father attachment relationships impact relationships children social development current investigation explored various correlates preschoolers child father attachment security parents including contextual factors socioeconomic status child temperament parenting stress parental play sensitivity child social adaptation participants included preschool aged children girls months fathers mothers results revealed mothers fathers play sensitivity associated child attachment security controlling different contextual factors furthermore magnitude association child conduct problems child father attachment insecurity stronger corresponding association child mother attachment insecurity findings provide important information caregiving factors associated child father attachment security preschool years importance bond children social adaptation
diversity antenna system antennas embedded rear view mirrors vehicle proposed satellite digital audio radio system antenna diversity needed hidden antennas exhibit limited capability composite body vehicles poor reception due ground plane availability pattern gain diversity achieved proposed system proven vehicle antenna simulations gain measurements selection combining diversity receiver architecture also proposed system tested real time two fading scenarios weak satellite signal dense foliage multipath terrestrial environment frequent satellite blockages cases diversity system outperformed reference antenna system less mutes times versus multipath versus dense foliage reed solomon block errors versus multipath versus dense foliage proposed rear view mirror location ideal minimum signal degradation compared windshield backlite dashboard antenna installations
energy management strategies emss hybrid electric vehicles hevs highly related fuel economy emission performances however ems constitutes challenging problem due complex structure hev unknown partially known driving cycles meet problem paper adopts stochastic dynamic programming sdp method ems specially designed vehicle pre transmission single shaft torque coupling parallel hev parallel hev auto clutch output connected transmission input electric motor benefits efficient motor assist operation ems demanded torque driver modeled one state markov process represent uncertainty future driving situations obtained ems evaluated advisor two standard government drive cycles self defined one compared dynamic programming one rule based one simulation results shown real time performance proposed approach potential vehicle performance improvement relative rule based one
aes represents algorithm advanced encryption standard consistof different operations required steps encryption decryption proposed architecture based optimizing area terms reducing slices required design aes algorithm vhdl paper presents aes bit algorithm design consist bit symmetric key aes implementation merging technique used wherein shiftrows mixcolumns addroundkeys transformations performed single vlsi module
bent functions actively investigated various applications cryptography coding theory combinatorial design one generalizations negabent functions also quite useful originally defined via nega hadamard transforms boolean functions paper look another equivalent definition allows investigate negabent functions written composition univariate polynomial trace mapping particular polynomial monomial call monomial negabent function families quadratic cubic monomial negabent functions constructed together several sporadic examples obtain interesting negabent functions special forms also look certain negabent polynomials obtain several families cubic negabent functions using theory projective polynomials finite fields
men human immunodeficiency virus hiv infection often hypogonadal develop several hiv associated non acquired immunodeficiency syndrome aids hana conditions impair overall health status studies explored relationship health status serum testosterone hiv infected men study aims investigate association total serum hana multimorbidity frailty large cohort hiv infected men explore relationship patients overall health status serum among biochemical hormonal measurement performed main serum total free triiodothyronine luteinizing hormone outcome measurements include anthropometry assessment comorbidities disabilities overall health status defined number hana item multimorbidity frailty index anthropometry bone mineral density cumulative relative risk comorbidities increased hiv infected men hypogonadism hypogonadism associated several comorbidities prevalence hypogonadism increases progressively increase number comorbidities frailty index inversely related serum total age adjusted serum levels significantly lower hypogonadal eugonadal men suggests low serum could considered sensitive marker frailty poor health status latter might induce hypogonadism hiv infected men frail hypogonadal suggests hypogonadism might naturally occurring condition unhealthy hiv infected men raises concern safety treatment conclusion low serum associated multimorbidity hana frailty hiv infected men association seems bidirectional given wide attitude offer treatment hiv infected men caution needed prescribing hiv infected male patients especially patient unhealthy frail
common approach used thermal design electrical machines calibrating thermal models based designer previous experience hardware tests prototype machine allows various manufacture assembly nuances accounted design process assuring accurate computationally efficient predictions machine thermal behaviour post manufacture calibration thermal models tests complete machine limited use development machine topologies previous experience machine hardware exist context experiment informed design technique makes use reduced order machine sub assemblies presents attractive alternative particular hardware manufacture cost time significantly reduced compared prototyping complete machine assembly allows numerous hardware samples constructed tested inform machine design process use machine sub assembly testing focused limited identifying quantifying various power loss heat transfer phenomena paper reviews applicability sub assembly testing broader context machine design aim research focuses formulating basis sub assembly based experiment informed methodology thermal design electrical machines
psychotic symptoms frequently occur parkinson disease pathophysiology poorly understood according national institute health rdoc programme pathophysiological basis neuropsychiatric symptoms may better understood terms dysfunction underlying domains neurocognition trans diagnostic fashion abnormal cortico striatal reward processing proposed key domain contributing pathogenesis psychotic symptoms schizophrenia theory received empirical support study schizophrenia spectrum disorders preclinical models psychosis tested psychosis associated therefore investigated brain responses associated reward expectation prediction error signaling reinforcement learning associated psychosis instrumental learning task monetary gains losses conducted fmri study patients without history psychotic symptoms along sample healthy controls conducted region interest analyses ventral striatum ventromedial prefrontal posterior cingulate cortices whole brain analyses reduced activation patients history psychosis compared without posterior cingulate cortex reward anticipation small volume corrected results suggest cortical striatal abnormalities reward processing putative pathophysiological mechanism psychosis schizophrenia may also contribute pathogenesis psychotic symptoms finding posterior cingulate dysfunction keeping prior results highlighting cortical dysfunction pathogenesis psychosis
idiopathic pulmonary fibrosis ipf common interstitial lung disease however pathogenesis remains fully elucidated melatonin secreted pineal gland strong antioxidant effect exerts anti fibrosis effect whether melatonin attenuates pulmonary fibrosis inhibiting epithelial mesenchymal transition emt requires research present study aimed investigate whether melatonin prevents transforming growth factor beta tgf beta induced emt underlying signaling pathways using reverse transcription quantitative polymerase chain reaction western blot analysis immunofluorescence results demonstrated melatonin inhibits emt cells wnt beta catenin smad signaling pathways involved emt cell line suppressed melatonin present study indicates melatonin inhibited tgf beta induced epithelial mesenchymal transition cell line may potentially useful treatment ipf
dual energy computed tomography dect significant impacts material characterization bone mineral density inspection nondestructive evaluation spite great progress made recently reconstruction algorithms dect still exist two main problems polyenergetic ray source tube spectrum needed reconstruction always available reconstructed image dect sensitive noise demands special noise suppression strategy reconstruction algorithm design paper propose novel method dect reconstruction reconstructs tube spectrum projection data suppresses image noise introducing norm based regularization statistical reconstruction polychromatic dect contribution work twofold three parameters model devised represent spectrum ployenergetic ray source parameters estimated projection data solving optimization problem estimated tube spectrum propose computation framework norm regularization based statistical iterative reconstruction polychromatic dect simulation experiments two phantoms conducted evaluate proposed method experimental results demonstrate accuracy robustness spectrum model terms comparable reconstruction image quality achieved estimated ideal spectrum validate proposed method works attractive performance terms accuracy reconstructed image root mean square error rmse reconstructed image ground truth image two phantoms respectively
background objectivebreast cancer one common cancers recognized third leading cause mortality women optical coherence tomography oct enables three dimensional visualization biological tissue micrometer level resolution high speed play important role early diagnosis treatment guidance breast cancer particular ultra high resolution uhr oct provides images better histological correlation paper compared uhr oct performance standard oct breast cancer imaging qualitatively quantitatively automatic tissue classification algorithms used automatically detect invasive ductal carcinoma vivo human breast tissue study design materials methodshuman breast tissues including non neoplastic normal tissues breast reduction tumor samples mastectomy specimens excised patients columbia university medical center tissue specimens imaged two spectral domain oct systems different wavelengths home built ultra high resolution uhr oct system measured axial lateral commercial oct system standard resolution measured axial lateral imaging performances analyzed qualitatively using regional features derived oct images produced two systems developed automated classification algorithm based relevance vector machine rvm differentiate hollow structured adipose tissue solid tissue developed scan based features rvm classify invasive ductal carcinoma idc normal fibrous stroma tissue among oct datasets produced two systems adipose classification uhr oct scans normal specimens standard oct scans normal idc specimens employed idc classification uhr oct scans normal idc specimens standard oct scans normal idc specimens employed resultswe demonstrated uhr oct images produce images better feature delineation compared images produced oct system uhr oct images variety tissue types found human breast tissue presented limited number datasets showed oct systems achieve good accuracy identifying adipose tissue classification uhr oct images achieved higher sensitivity specificity adipose tissue sensitivity specificity oct images idc classification similarly achieved better results uhr oct images featured overall accuracy sensitivity specificity preliminary study conclusionin study provided uhr oct images different normal malignant breast tissue types qualitatively quantitatively studied texture optical features oct images human breast tissue different resolutions developed automated approach differentiate adipose tissue fibrous stroma idc within human breast tissues work may open door toward automatic intraoperative oct evaluation early stage breast cancer wiley periodicals inc
background estimating burden non communicable diseases particularly cardiovascular disease cvd essential health management policymaking paper used regression model estimate future impact demographic changes burden cvd iran next two decades methods disability adjusted life years daly used estimate future burden cvd iran regression model used estimate daly caused cvd iranian population aged stratified age group sex predicted population iranians aged entered model daly calculated assess areas uncertainty model sensitivity analysis monte carlo simulation results year dalys caused cvd iranian adults aged figure nearly dalys words aging daly related cvd increase two fold compared burden cvd higher men women difference less conclusion burden cvd increase steeply iran mainly aging population therefore attention needed deal impact cvd following decades iran
possible conceptualisation formalism high level description complex reaction systems presented formalism intended framework adopting multi scale modelling simulation tools problems reverse design intensive processes design functional materials formalism exemplified several historical cases fields reaction materials engineering elsevier rights reserved
chronic cerebral hypoperfusion cch high risk factor alzheimer disease micrornas mirnas ideal mediators hypoxic stress responses facilitate cellular adaptation long term hypoxia mir kind nervous system specific mirnas one target genes beta site amyloid precursor protein cleaving enzyme bace present study mir found inhibited time early late stage cerebral hypoxia accompanying upregulation bace protein overproduction amyloid beta beta hippocampus cerebral hypoperfusion rat models meanwhile beta could enhance expression bace protein due inhibition mir thus mir key factor hypoxia beta mir bace beta cycle activation epac rap pathway involved inhibition mir hippocampus hypoxia beta insult data suggest endogenous regulator bace protein mir may play role onset induced cch
purpose support nurse practitioners encounters aging male patients signs symptoms related decline male sex hormones data sources electronic search conducted studies following databases pubmed cinahl scopus related health resources websites search terms used included male menopause andropause androgen deficiency testosterone deficiency late onset hypogonadism testosterone replacement therapy relevant studies english selected integrative review conclusions androgen deficiency syndrome overlooked clinical settings however increase health needs related low testosterone levels diagnosis made carefully considering possible causes problems well decision initiate testosterone treatment monitoring article current awareness androgen deficiency syndrome pathophysiology aging men sex organ clinical presentation differential diagnoses diagnostic strategy clinical management monitoring referral plans discussed implications practice rapidly growing aged population society makes androgen deficiency syndrome growing issue needs understood adequately diagnosed carefully managed nurse practitioners
controversy exists whether eicosapentaenoic acid epa docosahexaenoic acid dha responsible efficacy polyunsaturated fatty acids depression conducted single center randomized double blind placebo controlled multi arm parallel group trial comparing efficacy epa versus dha adjuvants maintenance medication treatments mild moderate depression eighty one mild moderately depressed outpatients randomly assigned receive either epa dha placebo coconut oil weeks primary outcome measure item hamilton depression rating scale hdrs final score modified intention treat population comprised randomized patients least post randomization observation female mean age years allocated treatments well tolerated although significant difference groups baseline patients epa group showed significantly lower mean hdrs score study endpoint compared dha decrease baseline hdrs score observed patients receiving epa one dha placebo groups responded treatment overall data suggest greater efficacy epa compared dha placebo adjunctive treatment mild moderate depression however randomized controlled trials needed support findings elsevier ecnp rights reserved
mandatory hiv screening united states air force usaf personnel every two years effectively identifies incident cases however testing frequency limits ability detect early hiv infection identifying clinical indicators hiv usaf population necessary develop supplemental provider based targeted testing strategy conducted matched case control study male active duty usaf personnel new hiv diagnosis matched five randomly selected controls relationship clinical diagnoses determined icd codes hiv infection assessed using conditional logistic regression unadjusted analyses icd codes ever within last two years hiv diagnosis conditional odds hiv infection greater clinical signs symptoms hiv cor mental health diagnoses cor sti diagnoses cor compared medical encounters two years prior hiv diagnosis individuals medical encounters cor medical encounters cor higher odds hiv acquisition multivariate analyses clinical signs symptoms hiv within last two years hiv diagnosis cor ever mental health diagnosis cor remained significant clinical encounters particularly featuring clinical signs symptoms hiv history mental health complaints provide opportunity targeted testing supplement mandated testing two year intervals provider education increase hiv testing persons risk would enhance early hiv diagnosis potentially reduce forward transmission usaf population
assess association indoor environmental risk factors respiratory function among adults acid rain plagued city china coal use frequent subjects randomly selected winter season information selected home environmental factors collected administered questionnaires additionally pulmonary function tests including forced vital capacity fvc forced expiratory volume fev fev fvc peak expiratory flow rate pefr also performed participants study showed among variety risk factors coal fuel use cooking oil fumes active passive smoking exposure together asthma childhood important factors deterioration pulmonary function among adults winter season additionally subjects whose kitchen located living room bedroom opened windows occasionally never noted presence cooking oil fumes pests whose bedroom shared residents kept pets tended exhibit lower values fvc fev pefr values compared non exposed counterparts study demonstrated impaired pulmonary function among adults exposed indoor risk factors coal fires cigarette smoking compared non users winter season emphasizes need public health efforts decrease exposure indoor air pollution
objectives hypothesis aid diagnosis meniere disease attacks using caloric head impulse tests hits study design retrospective case series review methods analyzed results bithermal caloric hits attacks patients quantitative analyses hits conducted using magnetic search coil technique results unilateral patients semicircular canals head impulse gain vestibulo ocular reflex vor either normal decreased increased semicircular canal affected ear likewise head impulse vor gain either normal increased decreased intact ear vor gain horizontal canal significantly lower affected side however vor gains anterior posterior canals differ sides bilateral two patients semicircular canals vor gain either decreased normal either ear contrast caloric responses usually decreased affected ear including one bilateral conclusion attacks hits showed varied results ears among canals although caloric responses usually decreased involved ear dissociations suggest frequency dependent impairment canal function mechanical property endolymphatic hydrops attacks
maintaining safe operation chemical processes meeting environmental constraints issues paramount importance area process systems control engineering ideally achieved maximizing economic profit long argued process safety fundamentally process control problem yet research efforts directed toward integrating rather disparate domains process safety process control economic model predictive control empc attracted significant attention recently due ability optimize process operation accounting directly process economics considerations however limited work problem integrating safety considerations empc ensure simultaneous safe operation maximization process profit motivated considerations work develops three empc schemes adjust real time size safety sets process state reside ensure safe process operation feedback control process state optimizing economics via time varying process operation recursive feasibility closed loop stability established sufficiently small empc sampling period proposed schemes effectively integrate feedback control process economics safety considerations demonstrated chemical process example american institute chemical engineers
study deals motion deformation compound drop system subject arbitrary stokes far field flow conditions presence hulk insoluble surfactants derive solutions fluid velocities resulting surfactant concentrations assuming capillary number surface peclet number small compared unity first focus concentric drop configuration apply lamb general solution assuming far field flow arbitrary nature representative case studies consider two cases flow dynamics linear flows flow dynamics poiseuille flow although latter case concentric configuration remain valid general look effective viscosity dilute suspension compound drops subject linear ambient flow compare predictions previously reported experiments subsequently eccentric drop configuration addressed using bipolar coordinate system far field flow assumed axisymmetric otherwise arbitrary nature specific example eccentric drop dynamics focus poiseuille flow study drop migration velocities analysis shows presence surfactant generally opposes imposed flows thereby acting like effective augmented viscosity analysis reveals maximizing effects surfactant makes drops behave like solid particles suspended medium however uniaxial extensional flow presence surfactants inner drop conjunction drop radius ratio leads host interesting non monotonic behaviours interface deformation eccentric drops effect eccentricity becomes noticeable surpasses certain critical value becomes prominent two interfaces approach depict surfactant eccentricity generally tend suppress effects droplet migration velocities
geoinformation science perspective real estate portals apply non spatial methods analyse visualise rental price data approach shows considerable shortcomings portal operators neglect real estate agents mantra exactly three things important real estates location location location stroisch although real estate portals retacord spatial reference listed apartments geocoded address data used insufficiently analyses visualisation many cases data used pin map listings date geoinformation science spatial statistics geovisualization play minor role real estate portals analysing visualising housing data contribution discusses analytical geovisual status quo real estate portals addresses serious deficits employed non spatial methods alternative analysing approaches geostatistics machine learning geovisualization demonstrate potentials optimise real estate portals analysing visualisation capacities
objectives purpose study determine level heterogeneity high grade serous ovarian cancer hgsoc analyzing rna expression single epithelial cancer associated stromal cells addition explored possibility identifying subgroups based pathway activation pre defined signatures cancer stem cells chemo resistant cells methods fresh hgsoc tumor specimen derived ovary enzymatically digested depleted immune infiltrating cells rna sequencing performed single cells single cell datasets passed quality control checks sequences analyzed using multiple bioinformatics tools including clustering principle components analysis geneset enrichment analysis identify subgroups activated pathways immunohistochemistry ovarian cancer stem cell stromal markers performed adjacent tumor sections results analysis gene expression patterns identified two major subsets cells characterized epithelial stromal gene expression patterns epithelial group characterized proliferative genes including genes associated oxidative phosphorylation myc activity stromal group characterized increased expression extracellular matrix ecm genes genes associated epithelial mesenchymal transition emt neither group expressed signature correlating published chemo resistant gene signatures many cells predominantly stromal subgroup expressed markers associated cancer stem cells conclusions single cell sequencing provides means identifying subpopulations cancer cells within single patient single cell sequence analysis may prove critical understanding etiology progression drug resistance ovarian cancer elsevier inc rights reserved
objective compare relative effects pharmacological thromboprophylaxis anticoagulation background efficacy safety pharmacological thromboprophylaxis cancer patients undergoing surgery need quantified guide management methods searched multiple electronic databases march trials cancer patients undergoing surgery assessed relative benefits harms perioperative pharmacological thromboprophylaxis relative risks rrs confidence intervals estimated results total studies enrolled review patients pharmacological thromboprophylaxis relatively reduced incidence deep venous thrombosis dvt compared without significantly increased incidence bleeding events incidence pulmonary embolism mortality related venous thromboembolism vte similar pharmacological thromboprophylaxis group pharmacological thromboprophylaxis group low molecular weight heparin lmwh reduced incidence dvt compared unfractionated heparin ufh standard extended thromboprophylaxis cancer surgery significant decreased incidence dvt compared conventional thromboprophylaxis conclusions routine pharmacological thromboprophylaxis cancer patients undergoing surgery needs carefully considered although thromboprophylaxis associated lower vte events higher incidence clinically significant bleeding events pharmacological thromboprophylaxis used extended thromboprophylaxis started preoperatively lwmh might effective strategy
teaching network analysis undergraduate students frequency response electrical circuits consisting passive elements resistors capacitors inductors commonly analysed students familiar sharp amplitude peak trough normally occurring resonance observation intuitively pleasing also consistent concept resonance many physical systems well known series parallel rlc circuits maximum minimum currents respectively occur resonance many students even instructors sometimes may erroneously assume resonance general rlc circuits implies maximum minimum current paper shown generally untrue theoretical analyses experimental validation series parallel series parallel rlc circuits presented address common misconception
objective use high dose cyclophosphamide without hematopoietic stem cell transplant treat severe aplastic anemia saa controversial due concern increased infectious toxicity compared antithymocyte globulin cyclosporine children often tolerate dose intensive therapy better adults sought perform detailed retrospective analysis treatment response toxicity patients younger years age treated courses high dose cyclophosphamide sole form immunosuppression study design children adolescents saa lacked human leukocyte antigen matched sibling donor treated cyclophosphamide consecutive days received daily granulocyte colony stimulating factor neutrophil recovery transfusion support antimicrobial prophylaxis results overall survival hematologic response complete response cumulative incidences bacterial infection fungal infection high deaths due infection rare clonal evolution clinically relevant paroxysmal nocturnal relapse conclusions response rates survival following high dose cyclophosphamide pediatric patients saa exceed seen adults compare favorably antithymocyte globulin cyclosporine manageable infectious toxicity
background monitoring wait times defining targets care advocated improve health care delivery related cancer heart diagnostic imaging joint replacements sight restoration data access care digestive diseases although pose greater economic burden cancer heart disease canada present study compared wait times specialist gastroenterology care recent evidence based consensus defined benchmark wait times range digestive diseases methods total wait times primary care referral investigation measured seven digestive disease indications using practice audit gastroenterology program bench marked consensus recommendations results total wait times patients undergoing investigation exceeded targets probable cancer median days percentiles eight days versus target two weeks probable inflammatory bowel disease days days versus two weeks documented iron deficiency anemia days days versus two months positive fecal occult blood test days days versus two months dyspepsia alarm symptoms days days versus two months refractory dyspepsia without alarm symptoms days days verb sus two months chronic constipation diarrhea days days versus two months minority patients seen within target times probable cancer probable inflammatory bowel disease iron deficiency anemia positive occult blood test dyspepsia alarm symptoms refractory dyspepsia without alarm symptoms chronic constipation diarrhea discussion total wait times seven indications exceeded consensus targets patients seen within target wait time multiple interventions including adoption evidence based management guidelines provision economic human resources needed ensure appropriate access digestive health care canada outcomes evaluated point care practice audit methodology used present study
background developed western settings asthma prevalent among second generation compared first generation migrants however studies difficult interpret include migrants various ethnicities countries origin objective assessed association parental migrant status wheezing disorders among children born hong kong developed non western setting many children migrant parents mainland china ethnicity methods used cox regression examine adjusted associations parental migrant status time first public hospital admission asthma bronchitis bronchiolitis international classification diseases ninth version clinical modification days years population representative birth cohort chinese children hong kong results parents migrants associated higher risk hospitalization asthma wheezing disorders compared parents hong kong born hazard ratio confidence interval days years adjusted type hospital birth parental history allergies mother age birth father age birth highest parental education conclusions clinical relevance unique non western context hong kong second generation migrants higher risk hospitalization childhood wheezing disorders compared native population particularly years age study required clarify underlying mechanisms involved
fast sensitive method proposed determine pregnenolone dehydroepiandrosterone dhea testosterone dihydrotestosterone human plasma steroids extracted liquid liquid extraction derivatized methyl trimethylsilyl trifluoracetamide electron ionization applied generate high abundant precursor ions specific precursor product transitions generated priori compound interest assays used selectively detect quantify steroids using selected reaction monitoring mode detection limits sub nmol range could achieved four steroid compounds method validated imprecision recovery applied pilot study patients hypercholesterolemia associations increased cholesterol biosynthesis low testosterone dihydrotestosterone concentrations found elsevier inc rights reserved
text detection natural environment plays important role many computer vision applications existing text detection methods focused english characters strong application demands text detection languages chinese paper present novel text detection algorithm chinese characters based specific designed convolutional neural network cnn cnn contains text structure component detector layer spatial pyramid layer multi input layer deep belief network dbn cnn pre trained via convolutional sparse auto encoder specifically designed extracting complex features chinese characters particular text structure component detectors enhance accuracy uniqueness feature descriptors extracting multiple text structure components various ways spatial pyramid layer enhances scale invariability cnn detecting texts multiple scales finally multi input layer dbn replaces fully connected layers cnn ensure features multiple scales comparable multilingual text detection dataset texts chinese english digits labeled separately set evaluate proposed text detection algorithm proposed algorithm shows significant performance improvement baseline cnn algorithms addition proposed algorithm evaluated public multilingual benchmark achieves state art result multiple languages furthermore simplified version proposed algorithm general components evaluated icdar datasets showing comparable detection performance existing general text detection algorithms
many years traditional process gardenia yellow pigment extraction produced wastewater containing significant quantities geniposidic acid gsa substance could put pharmacological uses could effectively recovered study aimed provide efficient adsorption material recycling gsa batch experiments showed adsorption capacity depends initial concentration temperature maximal adsorption capacity gsa onto anionic exchanger reached value gsa determined pore diffusion coefficients gsa respectively recovery efficiency gsa achieved comparison pseudo first order pseudo second order equations pdm model demonstrated best fit kinetics data gsa adsorption adsorption desorption experiments proved offers great adsorption capacity high adsorption rate good repeatability order help accurately comprehend mass transfer process numerical simulation post processing variables performed clarify adsorption process
melioidosis caused burkholderia pseudomallei predominately disease tropical climates especially widespread south east asia northern australia melioidosis affecting central nervous system low incidence high mortality present seven cases neuromelioidosis analyze disease characteristics imaging features typical clinical features disease included high fever headache five patients irregular fever temperature peripheral blood leukocytes neutrophil ratio raised patients computed tomography magnetic resonance imaging disease mainly manifested intracerebral single multiple nodules well ring flake like enhancements rapid lesion progression study demonstrated importance imaging examination clinical evaluation diagnosis neuromelioidosis
slope excavation one crucial steps construction hydraulic project excavation project quality assessment excavated volume calculation critical construction management positioning excavation projects using traditional instruments inefficient may cause error improve efficiency precision calculation assessment three dimensional laser scanning technology used slope excavation quality assessment efficient data acquisition processing management workflow presented study based quality control indices including average gradient slope toe elevation overbreak underbreak cross sectional quality assessment holistic quality assessment methods proposed assess slope excavation quality laser scanned data algorithm also presented calculate excavated volume laser scanned data field application laboratory experiment carried verify feasibility methods excavation quality assessment excavated volume calculation results show quality assessment indices obtained rapidly accurately design parameters scanned data results holistic quality assessment consistent cross sectional quality assessment addition time consumption excavation quality assessment laser scanning technology reduced compared traditional method excavated volume calculated scanned data slightly differs measured data demonstrating applicability excavated volume calculation method presented study hohai university production hosting elsevier
work apply high order discontinuous galerkin finite element method inviscid turbulent internal flow problems equations considered quasi euler equations rans omega equations axisymmetric coordinates method proposed designed ensure high order accuracy ducts engine like geometries using explicit implicit schemes temporal discretization governing equations absorbing sponge layer asl boundary conditions implemented minimize reflection going waves open boundaries shock capturing technique used control oscillations high order solutions around shocks accurate solutions hyperbolic equations performed means five stage fourth order accurate strong stability preserving runge kutta scheme implicit backward euler scheme adopted efficient steady state simulations internal turbulent flows two types test problems considered one focusing potential method solve ideal quasi waves propagation shock phenomena may occur ducts feasibility provide high order accurate solutions multi dimensional internal turbulent flows geometries typical internal combustion engine ice applications clearly illustrate performance high order method results compared exact solutions experimental data second order accurate solutions obtained finite volume commercial code elsevier ltd rights reserved
steady growth linked datasets available web becomes increasingly necessary creation efficient approaches analyzing search discover links rdf datasets paper describe lex architecture creates possibility indexing rdf datasets using gridfs documents probabilistic data structures called bloom filter hence lightweight approach provides metadata quantity quality links datasets moreover explored concepts indexing billion triples thousand datasets providing insights bloom filters behavior performance memory footprint
lysophosphatidic acid lpa bioactive lysophospholipid involved pathogenesis chronic inflammatory autoimmune diseases study investigated role lpa lpa receptor lpar signaling pathogenesis sjogren syndrome found autotaxin lpa producing enzyme lpar lpar mrna mrna highly expressed exocrine glands week old nonobese diabetic nod mice show symptoms age compared non symptomatic week old nod mice adoptive transfer model using nod lymphocytes treatment lpar antagonist restored tear saliva secretion decreased symptoms compared vehicle treated group levels serum lacrimal glands also significantly reduced recipient mice addition treatment week old nod mice spontaneously developed restored saliva volume treatment nod splenocytes lpa induced expression dose dependent manner inhibited increase lpa stimulated activation rock mapk inhibition rock mapk suppressed lpa induced expression data suggest lpar signaling stimulates development induction production via rock mapk pathways thus lpar inhibition could possible therapeutic strategy
construction projects become larger diversified various factors time cost quality environment safety need considered make difficult make final decision study conducted develop integrated multi objective optimization imoo model provides optimal solution set based concept pareto front following six steps problem statement definition optimization objectives establishment data structure standardization optimization objectives definition fitness function introduction genetic algorithm evaluate robustness reliability proposed imoo model case study construction time cost trade problem analyzed terms effectiveness efficiency results study used assess two optimization objectives initial investment cost operation maintenance cost emission trading cost take advantage weights real meanings evaluate four types fitness functions expand areas indoor air quality materials energy use
stochastic newton recursive algorithm studied dual rate system identification owing lack intersample measurements single rate model identified directly auxiliary model technique adopted provide intersample estimations guarantee recursion process continues intersample estimations great influence convergence parameter estimations one step innovation may lead large fluctuation even divergence recursion meantime sample covariance matrix may appear singular recursive process would cease reasons order guarantee recursion process also improve estimation accuracy multi innovation utilized correcting parameter estimations combining auxiliary model multi innovation theory auxiliary model based multi innovation stochastic newton recursive algorithm proposed time invariant dual rate systems consistency algorithm analyzed detail final simulations confirm effectiveness proposed algorithm
people dementia living residential aged care facilities racfs display behavioral psychological symptoms dementia bpsd associated poorer quality life increased morbidity mortality order implement appropriate interventions important understand symptoms detail despite availability bpsd assessment tools unknown current practice monitoring bpsd racfs sought investigate current bpsd assessment tools used racfs explore different stakeholders views current practices cross sectional convenience sample clinicians identified administered questionnaire old age psychiatrists aged psychiatry clinicians behavior management teams racf staff completed questionnaires clinicians reported objective consistent information bpsd important recommending implementing pharmacological non pharmacological strategies bpsd however use validated bpsd assessments racfs usual part clinical practice racf staff stated major barrier assessment bpsd lack time alternate methods assessing bpsd consider preferences clinicians racf staff investigated modern technology allow real time assessment may solution
paper explores extent people different origins natives migrants come together everyday life europe instead looking overall perceptions stances context dependent mediated political ideological currents discourses well broader patterns prejudice focus sustained close contacts suggest meaningful organic relationships since often people migrant background blamed leading parallel lives integrating chose focus interethnic friendships moreover seek understand relevance role neighbourhood context development relationships despite expressive fears public discourses supposed negative impact presence immigrants ethnic minorities social cohesion findings indicate close interethnic relationships uncommon diverse european cities highlight neighbourhood context plays important role first years migrants settlement relationships neighbourhood develop less formal social settings also less demanding terms host country cultural skills part migrants thus giving opportunity newcomers develop close interethnic relationships natives finally analysis supports positive role diversity neighbourhood level development interethnic friendships stresses importance neighbourhood socio spatial characteristics location wider urban net
paper presents design studies performed first phase implementation project partnership energetic company minas gerais cemig objective project evaluate benefits limitations using storage grid connected system specifically evaluate injecting energy stored batteries charge electric grid order flatten peak load curve feeder system evening peak electricity consumption experienced area storage system installed football stadium arena jacare located sete lagoas minas gerais initial studies performed define characteristics array including surveys region characteristics solar resource climate data additionally characteristics optimum generator configuration module technology evaluated taking consideration stadium limited available area defined orientation major design criterion eliminate shadow projection photovoltaic modules could reduce performance initial design generator structure geometry system performance simuulated projected conditions innovative feature project bidirectional conversion connection unit capacity store energy coming generator electrical network battery bank unit deliver energy grid feeder operated cemig tests specific defined times peak time area conclusion protype project larger scale system photovoltaic system connected network storage installed green ipuc pucminas utilizing lessons learned experiences equipment developed minas gerais arena jacare stadium
objective aggressive behaviour associated reduced serotonin metabolism brain enough knowledge potential changes serotonin precursor levels among violent offenders study aimed evaluate relationships among tendency psychopathy anger basic amino acids methods fifty two young adult male patients antisocial personality disorder apd healthy men included study serum amino acid levels measured hplc method aggression questionnaire hare psychopathology scale used participants results blood levels phosphoserine aspartic acid glutamic acid aminoadipic acid methylhistidine group patients apd significantly higher control group blood levels trp asparagine citrulline cystine isoleucine tyrosine histidine hydroxylysine lysine ethanolamine arginine group patients found lower control group significant positive correlation anger scores histidine methionine gaba found gaba methionine showed significant correlation indirect aggression score conclusion study showed relationship serum amino acid levels scores aggression psychopathy think productive research area understanding relationship among biochemical factors aggression psychopathy
paper discusses possible approach distributed visualization rendering system infrastructure organization based linux environment usage virtualization technologies particular attention paid minutiae may encountered due environment setup exploitation processes may affect system performance usability applications development tools studied provide rapid onset computing resources exploration
coffee cup calorimetry performed calorimeters made styrofoam coffee cups familiar experiment general chemistry laboratory calorimeters inexpensive easy use provide good insulation thermodynamics experiments paper presents successful substitution paper coffee cups styrofoam cups construct homemade calorimeters important modifications experimental protocol using paper cup calorimeters discussed data collected using calorimeters constructed two types cups presented order demonstrate comparable results obtained enthalpy neutralization acid base reaction heat capacities metals results also compare favorably published values finally approach using scientific literature help general chemistry students examine whether paper styrofoam cups provide greener option discussed
purpose aim study examine whether critical access hospitals cahs predominant type hospital small isolated rural areas perform better worse prospective payment system pps hospitals measures quality methods healthcare cost utilization project state inpatient databases american hospital association annual survey data used analyses total discharges nonfederal general hospitals fewer beds included analyses cahs pps hospitals outcome measures included bivariate indicators adverse events including complications surgical care developed agency healthcare research quality patient safety indicators multiple logistic regression models developed examine relationship hospital adverse events cah status findings compared pps hospitals cahs significantly less likely observed unadjusted adverse event indicators adjusting patient mix hospital characteristics cahs perform better indicators accounting number discharges eliminated differences cahs pps hospitals likelihood adverse events across indicators except one conclusions study suggests differences surgical patient safety outcomes cahs pps hospitals comparable size reinforces central role cahs providing quality surgical care populations rural isolated areas underscores importance strategies sustain rural surgery infrastructure
creation brand new highly intelligent systematic distribution electric grids unified energy system russia intelligent grid smart grid considered priority scientific technical progress electricity industry according energy strategy russia period concept smart grid includes providing automated energy accounting creation intellectual protection control including alternative sources network distributed power generation one important elements modern electrical network relay protection provides localization damaged equipment possible fault regimes minimize amount damage maintaining stability rest grid power system source consumers varying power consumption renders recognizing fault regimes problematic due various interfering factors startups self startups powerful electric motors transformers switching idle mode large power flows transit lines transient resistance electric arc fault location creation state art high intelligence devices relay protection stage development requires verify functioning algorithms assess ability recognize fault regime background acceptable regimes developed method assessing information signs describing regimes electric networks linear polynomial decision functions article also proposes criteria assessing information signs perspective separating regime recognition areas authors discuss ways build recognition systems relation relay protection electric networks authors published elsevier ltd
prenatal development nervous system may susceptible environmental toxicants secondhand smoke authors assessed effects prenatal postnatal secondhand smoke exposure neurodevelopment month infants subjects mother infant pairs medical problems taken mothers children environmental health study prenatal postnatal exposures secondhand smoke determined using maternal self reports examiners unaware exposure history assessed infants months age using bayley scales infant development bayley scores compared secondhand smoke exposed unexposed groups adjusting potential confounders multiple logistic regression analysis carried estimate risk developmental delay posed shs exposure multivariate model included residential area maternal age pre pregnancy body mass index education income infant sex parity birth weight type feeding adjusting covariates secondhand smoke exposure pregnancy found related decrease mental developmental index score decrease psychomotor developmental index score addition secondhand smoke exposure pregnancy found increase risk developmental delay mental developmental index score months study suggests infants non smoking women exposed secondhand smoke risk neurodevelopmental delay elsevier inc rights reserved
studies diurnal sleep wake rhythm patients lung cancer mostly examined patients cross sectionally whereas effects lung cancer treatment time rarely considered long term longitudinal tracking patients lung cancer study examined changes sleep wake rhythm sleep quality anxiety depressive symptoms fatigue quality life qol various treatment stages addition factors affecting qol explored hierarchical linear modeling adopted analyze convenience sample patients lung cancer changes sleep wake rhythm sleep mood anxiety depressive symptoms fatigue qol observed five time points prior treatment weeks start treatment effects sex age cancer stage treatment type comorbidities time controlled determine predictors patients qol results showed patients sleep wake rhythms poor treatments compared baseline sleep wake rhythms patients significantly improved week anxiety significantly improved weeks contrast fatigue became exacerbated weeks moreover qol improved significantly week end treatment period qol negatively affected poor sleep quality beta depressive symptoms beta positively affected regular sleep wake rhythms beta therefore clinical health care professionals focus attention fatigue levels patients lung cancer treatment health care professionals may also need provide patients health education regarding sleep hygiene emotional support assist maintaining regular sleep wake rhythms order improve qol
background people living hiv plwh substance use disorder sud tend receive inadequate medical care part siloed healthcare system hiv substance use services delivered separately ideal treatment requires interdisciplinary team based coordinated care approach many structural systemic barriers impede integration hiv sud services current protocol describes development preliminary evaluation care coordination intervention cci consisting tablet based mobile platform hiv sud treatment providers interagency communication protocol training protocol hypothesize hiv sud treatment providers find cci acceptable receipt cci providers exhibit higher retention dual care among patients report increased frequency quality communication report increased rates relational coordination methods design three phase approach used refine evaluate cci phase consists depth qualitative interviews key stakeholders well clinical audits participating hiv sud treatment agencies phase contains functionality testing mobile platform frontline hiv sud treatment providers followed refinement cci phase consists pre post test trial sud hiv treatment providers data collected provider organization patient levels providers complete assessments baseline immediately post training months post training organizational data collected baseline months post training patient data collected baseline months post training discussion study develop evaluate cci consisting tablet based mobile platform treatment providers interagency communication protocol training protocol means improving integration care plwh sud results potential advance field bridging gaps fragmented healthcare system improving treatment efficiency work flow communication among interdisciplinary providers different treatment settings
recent studies show complex genetic architecture schizophrenia driven part polygenic components cumulative effect variants small effect many genes well rare single locus variants large effect sizes discuss genetic aberrations known copy number variants cnvs fall latter category associated high risk neuropsychiatric disorders briefly review recurrent cnvs associated highlight one cnv particular recurrent deletion chromosome estimated confer fold increased risk additionally describe use genetic mouse models behavioral tools patient derived induced pluripotent stem cells means study cnvs hope gaining mechanistic insight respective disorders taken together genomic data connecting cnvs multitude human neuropsychiatric disease current technical ability model chromosomal anomalies mouse existence precise behavioral measures endophenotypes argue time ripe systematic dissection genetic mechanisms underlying disease wiley periodicals inc
mapping ontologies relational databases necessity realising semantic web vision work concerning topic either extracted owl schemas using limited range owl modelling constructs relational schemas extracted relational schemas owl schemas represent owl schemas much possible contrast propose general framework maps relational databases schemas expressed owl particular regard transformation databases ontologies two phase process firstly convert relational schemas owl schemas enrich owl schemas highly expressive axioms based analysing schemas data databases testing data analysis heuristics number databases show produce owl schemas include semantic information found respective relational schemas
endocannabinoid ecb system attracted attention role various behavioral brain functions therapeutic target neuropsychiatric disease states including anxiety disorders conditions resulting dysfunctional responses stress mini review highlight components ecb system offer potential druggable targets new anxiolytic medications emphasizing less well discussed options discuss selectively amplifying ecbs recruitment interfering ecb degradation via fatty acid amide hydrolase faah monoacylglycerol lipase magl linked reductions anxiety like behaviors rodents variation human anxiety symptoms also discuss non canonical route regulate ecb degradation involves interfering cyclooxygenase cox next discuss approaches targeting ecb receptor signaling ways involve cannabinoid receptor subtype cbr targeting cbr subtype transient receptor potential vanilloid type trpv finally review evidence cannabidiol cbd representing less specific pharmacological approach may another way modulate ecbs interacting neurotransmitter systems alleviate anxiety taken together various approaches provide range plausible paths developing novel compounds could prove useful treating trauma related anxiety disorders published elsevier ltd
aim paper study shear transfer mechanism horizontal contact surface two rigid blocks shear resistance offered contact interface main mechanism mobilized structural elements many ancient stone dry masonry structures order transfer horizontal actions earthquakes wind forces foundation cases certain connection exists two blocks contact surface materialized wooden metal parts central area blocks poles empolia role connection transferring horizontal forces influence seismic behaviour point long debated research community cyclic experiments performed laboratory strength materials structures aristotle university thessaloniki greece order study sliding behaviour interface two rigid blocks experimental sequence investigation divided two groups first group includes specimens without connection rigid blocks second group includes specimens poles empolia connecting rigid blocks tests imposed cyclic horizontal sliding displacement combined constant level vertical load applied top upper block experimental process became possible describe shear transfer mechanism diagrams horizontal sliding displacement versus horizontal load study effects shear transfer behaviour rigid blocks without connection poles empolia numerical finite element simulations shear transfer mechanism also performed utilizing two commercial finite element software packages
construction robot applications controller important producing good performance robot system paper presents modeling simulation multi fingered robot hand mfrh conventional modern controllers output responses analyzed swarm algorithm known particle swarm optimization pso used find optimum solutions large search space simulation modern controller pso pid produced better results conventional controller terms system parameters rise time settling time steady state error maximum overshoot servomotor speed control mfrh
background opiate overdose deaths occur annually ireland overdose prevention management including naloxone prescription priority healthcare services naloxone effective overdose treatment considered wider lay use aim establish gps views experiences opiate addiction overdose care naloxone provision design setting anonymous postal survey gps affiliated department academic general practice university college dublin ireland method total gps invited complete anonymous postal survey results compared parallel trainee survey results total gps responded approximately one third gps based urban rural mixed areas gps responded patients used illicit opiates prescribed methadone two thirds gps favour increased naloxone availability community almost one third would take part scheme higher proportion trainees used naloxone treat opiate overdose qualified gps addition higher proportion trainees willing involved naloxone distribution qualified gps intranasal naloxone much preferred single multiple dose intramuscular naloxone gps objected wider naloxone availability favour conclusion gps report extensive contact people opiate use disorders provide limited opiate agonist treatment support wider availability naloxone would participate expansion development evaluation implementation strategy support based distribution urgently needed
three experiments examined whether people spontaneously generate evaluations target individuals circumstances also known generate spontaneous trait inferences stis first experiment used standard savings relearning paradigm explore whether exposure trait implicative behavior descriptions facilitates learning evaluatively congruent well behaviorimplied personality traits evidence facilitated learning evaluatively congruent traits obtained led second experiment savings relearning paradigm altered directly assess participants relearning evaluative words good bad results demonstrated trait implicative behavioral stimuli produce spontaneous trait inferences spontaneous evaluations measured correctly outcomes replicated third study using false recognition paradigm implications findings impression formation processes possible independence semantic information evaluative information discussed
paper tries present concentration dynamic principal quality indicators groundwater balesti tamasesti perimeter gorj county last years special geographical area groundwater closed land surface making vulnerable anthropic pollution area declared common order mesd mard area included list localities nitrates sources agricultural activities characterization groundwater quality studied perimeter based physico chemical analysis bulletins hydro geological drillings national network groundwater monitoring execution period studied perimeter part hydro geological stations well citizens wells monitored wells chosen flow direction groundwaters established original hydro geologic map hydro geologic section elaborated sub carpathian hillock depression according report implementation nitrates directive published european commission southern romania among areas groundwater contain elevated levels nitrates due use chemical fertilizers organic nitrates major source water pollution member states decrease quantities nitrate water implementation legislation designed prevent pollution land water nitrates agriculture became success following conducted monitoring gorj area romania observed significant appreciation quality indicators groundwater sowe could recommend implementation measures protect continuing rehabilitating groundwater quality balesti building sewage evacuation disposal plants quality groundwater could return nitrogen compound concentration values existing natural background groundwater
histone deacetylase inhibitors hdacis emerged new class anticancer agents targeting biological process including cell cycle apoptosis investigated explained anticancer effects hdac inhibitor ricolinostat alone combination bendamustine lymphoma cell lines cell viability measured mtt assay apoptosis reactive oxygen species ros generation bcl protein expression cell cycle progression tubuline expression determined flow cytometry effects ricolinostat alone combination caspases pik akt bcl pathways stress upr assessed immunoblotting ricolinostat shows anti lymphoma activity used single agent capability induce apoptosis synergistically potentiated bendamustine lymphoma cell lines drug combination reduced proportion cells phases caused increase sub peak synergistic effect accompanied increased ros activation caspase cleavage parp modulated bcl proteins family addition exposure ricolinostat induced acetylation level alpha tubulin extend modified bendamustine finally apoptosis effect ricolinostat bendamustine may mediated corresponding effect microtubule stabilization data suggest ricolinostat combination bendamustine may novel combination potential use antitumor agent lymphoma
time pervasive reality many relational database approaches developed cope practical applications facts repeat several times overall period time containing repetitions may known consider january john attended five meetings bioinformatics project temporal relational databases faced facts repeated known periodic time single facts occurred temporally indeterminate time conjunction non periodic repetitions temporal indeterminacy faced yet coping problem requires depth extension current techniques paper introduced new data model new definitions relational algebraic operators coping issues studied properties new model algebra emphasis reducibility property integrated models literature
carbon monoxide poisoning affects people year united states clinical presentation runs spectrum ranging headache dizziness coma death mortality rate ranging significant number patients survive poisoning suffer long term neurological affective sequelae neurologic deficits necessarily correlate blood levels likely result pleiotropic effects cellular mitochondrial respiration cellular energy utilization inflammation free radical generation especially brain heart long term neurocognitive deficits occur patients whereas approximately one third moderate severely poisoned patients exhibit cardiac dysfunction including arrhythmia left ventricular systolic dysfunction myocardial infarction imaging studies reveal cerebral white matter hyperintensities delayed posthypoxic leukoencephalopathy diffuse brain atrophy management patients requires identification accompanying drug ingestions especially setting intentional poisoning fire related toxic gas exposures inhalational injuries conventional therapy limited normobaric hyperbaric oxygen available antidotal therapy although hyperbaric oxygen significantly reduces permanent neurological affective effects poisoning portion survivors still substantial morbidity early success therapies targeting downstream inflammatory oxidative effects poisoning new methods directly target toxic effect scavenging agents currently development
growth urban areas impact urban ecosystems public health urban sustainability leading issues academic public interest million chinese people suffer pollen allergy pollen allergy induces bronchitis bronchial asthma pulmonary heart disease may even life threatening thus pollen allergies greatly affect daily life individuals high resolution worldview remote sensing data vegetation distribution features used detect dominant tree species study area obtain canopy distribution information different tree species way sources pollen different tree species identified using remote sensing technology overall accuracy tree species recognition study area exceeds plants study area flower spring pollen allergenic risk zones extensive spring sparse fall based spatial ranges pollen dispersal different seasons areas identified might contain pollen concentrations detrimental pollen sensitive individuals
background inflammatory bowel disease ibd considered result interplay host intestinal microbiota pathogenesis incompletely understood ibd adults shown associated marked changes body fluid metabolomics studies children hence prospective study addressed faecal serum metabolomics newly diagnosed paediatric ibd methods paediatric patients ibd undergoing diagnostic endoscopies controls also endoscopy signs inflammation provided blood stool samples tertiary care hospital blood inflammatory markers faecal calprotectin levels determined serum faecal metabolomics determined using ultra high pressure liquid chromatography coupled mass spectrometer results serum faecal metabolite profiles newly diagnosed paediatric ibd patients different healthy controls categorized crohn disease ulcerative colitis patients separate groups serum amino acid metabolism folate biosynthesis signalling pathways perturbed crohn disease also sphingolipid metabolic pathways perturbed compared controls faecal samples increased level several metabolites contrast low intermediate levels crohn disease clear correlation level inflammation faecal calprotectin levels profile various biologically important metabolites carnosine ribose significantly choline conclusion characterization inflammatory pattern using metabolomics analysis promising tool better understanding disease pathogenesis paediatric ibd
symbolic computation underpinned number key advances mathematics computer science applications typically large potentially highly parallel making good candidates parallel execution variety scales multi core high performance computing systems however much existing work parallel computing based around numeric rather symbolic computations particular symbolic computing presents particular problems terms varying granularity irregular task sizes match conventional approaches parallelisation also presents problems terms structure algorithms data paper describes new implementation free open source gap computational algebra system places parallelism heart design dealing key scalability cross platform portability problems provide three system layers deal three important classes hardware individual shared memory multi core nodes mid scale distributed clusters multi core nodes full blown high performance computing systems comprising large scale tightly connected networks multi core nodes requires develop new cross layer programming abstractions form new domain specific skeletons allow seamlessly target different hardware levels results show using approach achieve good scalability speedups two realistic exemplars high performance systems comprising cores well ubiquitous multi core systems distributed clusters work reported paves way towards full scale exploitation symbolic computation high performance computing systems demonstrate potential two major case studies authors concurrency computation practice experience published john wiley sons ltd
background investigated changes hepatic fibrosis based transient elastography among human immunodeficiency virus hiv infected patients without hepatitis virus hbv coinfection antiretroviral therapy art zambia methods patients liver stiffness measurements lsm kilopascals kpa art initiation categorized minimal fibrosis equivalent metavir significant fibrosis cirrhosis repeated following year art stratified hbv coinfection status hepatitis surface antigen positive baseline described lsm change proportion increase decrease fibrosis category using multivariable logistic regression assessed correlates significant fibrosis cirrhosis year art results among patients analyzed hbv coinfection median age years women median baseline count cells nearly patients received tenofovir disoproxil fumarate containing art line nationally recommended first line treatment median lsm change kpa confidence interval similar without hbv coinfection significant fibrosis cirrhosis decreased frequency increased age male sex hbv coinfection predicted significant fibrosis cirrhosis year conclusion percentage hiv infected zambian adults elevated liver stiffness suggestive significant fibrosis cirrhosis decreased following art initiation regardless hbv status suggests hiv infection plays role liver inflammation hbv coinfected patients likely significant fibrosis cirrhosis year art clinical trials registration nct
background aims postmenopausal status correlated increased metabolic syndrome mets cardiovascular risks however vital roles age mets associated risk factors sex specific arterial stiffness remain unclear methods population based cross sectional study general population enrolled health examination program adult participants measured brachial ankle pulse wave velocity bapwv assess arterial stiffness piecewise linear regression models used survey pre defined ages associated menopause andropause relation arterial stiffness multivariate linear regression analyses used evaluate independent determinants results across gender stepwise increases bapwv corresponded increased mets associated risk scores metsrs aging trend turning point found years age age incremental ratios bapwv presented inverse curves aging whereas highest values incremental ratios bapwv found age across gender comparing men women fold higher incremental ratio bapwv observed age compared fold age respectively mets risk group age associated stepwise increased bapwv across gender trend age determinants include crp women compared men metsrs lost determinant across gender contrast men women age hdl additional determinant triglyceride metsrs remained determinant across gender conclusions arterial stiffness increased aging across nearly lifelong ages women men menopause andropause may play role age critical factor across gender sex specific differences determinants arterial stiffness may remind sex specific targets interventional studies associated arterial stiffness elsevier rights reserved
port facilities organized microgrids pursue efficient electrical utilization based four pillars sustainable energy use levelled less local load lele lolo paper deals special case sts cranes characterized high power peaks low load factor require sized electrical network cause high costs electrical utilities charge greatly power peaks reasons paper discusses comprehensive peak shaving solution implements coordination cranes duty cycles power optimization tool energy storage systems ultracapacitors flywheels allowing port operator optimize power demand well network design suggested hybrid solution combines board crane adequate number ultracapacitors shore transformer substation flywheel modules operating simultaneous behavior cranes group
paper describes development motivating innovative multi robot formation control platform laboratory experiments mobile robots platform composed two components simulator environment experiment low cost wheeled mobile robots environment constitutes ready use test tool provides engineering students opportunity simulate test many different formation cooperation control strategies real system currently platform used systems control engineering master program offered national university distance education uned complutense university madrid ucm spain use platform exposes students hands laboratory sessions contributing development engineers
midurethral synthetic slings mus become standard care management stress urinary incontinence however associated development novo overactive bladder symptoms leading cause poor patient satisfaction sling surgery purpose review focus incidence risk factors management novo overactive bladder oab symptoms sling placement recent studies determined risk factors identification patients highest risk develop novo oab bladder outlet obstruction urinary tract infections foreign bodies need ruled prior management novo oab recent data focused specific therapies may improve novo oab results including onabotulinumtoxina oral medications novo oab common post operative complication may organic idiopathic research needs focus etiology management common mus complication
nonlocal symmetry obtained lax pair residual symmetry relating truncated painleve expansion derived link residual symmetry nonlocal symmetry obtained lax pair presented residual symmetry localized lie point symmetry prolonging original equation larger system finite transformation residual symmetry equivalent second type darboux transformation furthermore applying standard lie group approach prolonged system new similarity reductions exact interaction solutions solitons cnoidal periodic waves given difficult found traditional methods elsevier rights reserved
future automotive innovations realized software automotive industry facing transition mechanical software engineering achieve successful product launches also true manufacturing engineering paper presents empirical study interaction organizations product development manufacturing specifically focusing automotive software engineering presented multiple case study qualitative approach data collected documents interviews practioners two swedish automotive companies obtain validity results multiple information sources triangulated within case analysis cross case analysis concluded challenges research area since issues emerged data furthermore majority findings supported data sources cases indicates possibility generalize results automotive domain
paper contains development verification low noise amplifier stages lna within framework front end digital satellite radio diversity receiver operating around ghz first low noise high gain lna developed reach high requirements satellite radio reception therefore single ended cascode architecture chosen simulated noise figure gain second differential stage designed fulfill specification regards backward isolation common mode rejection circuit measured gain backward isolation furthermore two stages combined integrated balun overall performance verified due good noise performance first stage overall noise figure gain backward isolation whole circuit current consumption finally lna performance compared state art lnas
paper presents design experimental evaluation long range solar powered sensor enhanced radio frequency identification rfid tag tag antenna multiport microstrip patch overlay thin film solar cells energy harvesting second port allocated patch antenna supplementary energy harvesting signal transmitted reader rfid chip along microcontroller unit mcu temperature humidity sensor incorporated tag design implement low cost wireless sensor using commercial rfid reader measurements fabricated rfid tag sensor demonstrate maximum sensing reading range achieved circuits powered using solar cells secondary option energy harvesting proposed sensor dual energy harvesting achieves longer range lifetime compared similar battery powered sensor enhanced rfid tags rfid sensor also evaluated climate chamber sensor data temperature humidity remotely recorded excellent accuracy using commercial ultra high frequency uhf rfid reader addition sensor programmed temperature humidity surveillance sensitive items found various supply chain transportation applications
huge amount literature last decades showed sleep essential children health well short sleep duration associated several negative health outcomes many developmental phases infancy childhood strict relationship healthy sleep last years specific recommendations made much sleep children need published empirical evidences contemporary sleep recommendations changed new recommendations clearly different previous ones reflect clearly changes sleep need children adolescents last decades although seem still largely unfitting preadolescence adolescence sleep treated therapeutic intervention consensus guidelines statements evidence based best practice documents needed underpin sleep recommendations children sleep recommendations children play important role public policies interventions advertise parents children negative consequences sleep deprivation reduction
sensor systems site monitoring contaminated water trace organic compounds currently development permit near real time analysis samples containing multiple analytes investigate sensor signal processing approach based estimation theory specifically kalman filter approach permits estimation analyte concentration binary mixtures line sensor response reaches equilibrium sensor signals binary mixtures btex compounds benzene toluene ethylbenzene xylenes analyzed compounds good indicators accidental releases fuel oil groundwater based previous recent experimental results models sensor response binary mixtures developed sensor response model transformed state space representation estimation theory could used estimate sensor parameters state space form tested using available measured data results indicate relatively accurate estimates analyte concentration obtained within short period time four six minutes less tested sensor system well sensor response reaches equilibrium minutes
paper presents satellite orthogonal frequency division multiplexing sat ofdm technology satellite radio interface international mobile telecommunications imt advanced sat ofdm radio interface designed provide various advanced imt services satellite environments cost effective deployment satellite imt advanced system radio interface must high degree commonality third generation partnership project long term evolution gpp lte technology imt advanced also number different features features needed adapt gpp lte technology satellite specific environments long round trip delay large cell size slow fading satellite channel paper summarize key features sat ofdm technology propose satellite specific features included sat ofdm technology adaption way lte satellite show performance evaluation results sat ofdm technology see feasibility lte satellite copyright john wiley sons ltd
conventional explanations lax gun control laws media violence single working parents adequately explain recent spate school shootings neither bullying explanation recently gaining traction certain type bullying however revealed particularly culpable many recent shootings share disturbing component perpetrators repeatedly even relentlessly accused preps jocks gay gay harassment proposed point departure understanding causes school shootings boys believe level warrant privilege instead harassed may feel driven avenge wrong assert dominant powerful victorious masculinity circumstances call cultural transformation boys boys longer used alibi violence author presents implications school based social work practice teacher administrator interventions well prevention strategies
background contaminants various sources curious findings cervicovaginal smears pose diagnostic challenges especially need distinguished pathogens candidiasis frequently encountered fungal infection fungal contaminants relatively common detection fruiting bodies spores aspergillus species uncommon may represent either true infection contamination study undertaken evaluate presence fungal spores hyphae fruiting bodies routine cervical smears distinguish true infection contamination methods conventional cervicovaginal smears collected women incidentally found fungal fruiting bodies spores smears received cytology department one month reviewed presence elements results five smears received outpatient department period three consecutive days showed evidence fungal organisms patients years age four patients asymptomatic one patient complained minimal vaginal discharge immunocompetent cervicovaginal smears prepared part routine screening fungal fruiting bodies branching hyphae numerous spores seen otherwise normal smears culture scrapings surface wooden spatulas grew aspergillus niger conclusions contamination pap smears fungus must distinguished true infection latter supported positive clinical findings presence significant inflammation smears literature review done see range contaminants detected pap smears diagn cytopathol wiley periodicals inc
disrupted iron metabolism implicated pathogenesis parkinson disease progressive neurodegenerative disorder severely affects movement coordination yet molecular mechanisms underlying association remain unknown end performed transcriptomic meta analysis four blood microarrays observed significant downregulation genes related hemoglobin including hemoglobin delta hbd alpha hemoglobin stabilizing protein ashp genes implicated iron metabolism including solute carrier family member slca ferrochelatase fech erythrocyte specific genes including erythrocyte membrane protein epb aminolevulinate synthase alas pathway network analysis identified enrichment processes related mitochondrial membrane oxygen transport oxygen heme binding hemoglobin complex erythrocyte development tetrapyrrole metabolism spliceosome collectively identified subnetwork genes blood may provide molecular explanation disrupted hemoglobin iron metabolism pathogenesis
use conventional drip alternative micro irrigation systems evaluated years six newly planted cultivars earliblue duke draper bluecrop elliott aurora northern highbush blueberry vaccinium corymbosum drip system included two lines tubing side row line drip emitters every alternative systems included geotextile tape microsprinklers geotextile tape placed alongside plants dispersed water nutrients entire length microsprinklers installed every plant height nitrogen applied fertigation annual rates drip geotextile tape micro sprinklers end first season plant size terms canopy cover greatest geotextile tape average lowest microsprinklers drip lower rate following year canopy cover similar geotextile tape drip higher rate cultivar lowest microsprinklers draper cultivars geotextile tape drip higher rate resulted greater leaf concentrations microsprinklers drip lower rate particularly first year planting third year yield averaged among cultivars similar geotextile tape drip either rate lower microsprinklers overall drip cost effective geotextile tape fertigation drip sufficient maximize early fruit production cultivar microsprinklers less effective comparison resulted white salt deposits fruit
background pollen exposure acute adverse effects sensitized individuals information prevalence respiratory diseases areas different pollen concentrations scanty aim performed ecologic analysis assess whether prevalence allergic rhinitis asthma young adults varied across areas different pollen concentrations italy methods questionnaire respiratory diseases delivered random samples year old subjects six centers data daily air concentrations major allergologic pollens poaceae urticaceae oleaceae cupressaceae coryloideae betula ambrosia collected center specific pollen exposure indicators calculated including average number days per year pollens low high concentration thresholds defined italian association aerobiology associations pollen exposure disease prevalence adjusted potential confounders estimated using logistic regression models center random intercept results overall subjects filled questionnaire allergic rhinitis significantly less frequent centers longer periods high concentrations least one per days least two pollens associations number days least one least two pollens low thresholds borderline significant asthma prevalence associated pollen concentrations conclusions study support prevalence allergic rhinitis asthma greater centers higher pollen concentrations clear whether observed ecologic associations hold individual level elsevier rights reserved
background bone mineral content bmc bone mineral density bmd positively correlated dietary protein intakes account bmc bmd variances however relation bone strength microstructure variables captured areal bone mineral density abmd dietary protein intakes particularly specific dietary sources clearly established objective investigated association peripheral skeleton predicted failure load stiffness bone microstructure dietary protein intakes various origins animal divided dairy nondairy vegetable origins healthy postmenopausal women design cross sectional study caucasian women aged measured abmd use dual energy ray absorptiometry distal radius tibia bone microstructures use high resolution peripheral quantitative computerized tomography bone strength use finite element analysis evaluated dietary protein calcium use validated food frequency questionnaire results mean dietary calcium protein intakes greater recommended amounts class age predicted failure load stiffness distal radius tibia positively associated total animal dairy protein intakes vegetable protein intake failure load differences accompanied modifications abmd cortical trabecular bone microstructures associations remained statistically significant adjustment weight height physical activity menopause duration calcium intake interaction calcium protein intake principal component analysis volumetric bmd bone microstructure indicated trabecular bone mainly contributed positive association protein intakes bone strength conclusions results recorded homogeneous population healthy postmenopausal women indicate beneficial effect animal dairy protein intakes bone strength microstructure specifically positive association bone failure load stiffness peripheral skeleton dietary protein intake mainly related changes trabecular microstructure
objective assessed sensitivity specificity electronic health record ehr based phenotypes diabetes mellitus gold standard american diabetes association ada diagnostic criteria via chart review clinical experts materials methods identified ehr based diabetes phenotype definitions developed various purposes variety users including academic medical centers medicare new york city health department pharmacy benefit managers applied definitions sample patients records duke health system enterprise data warehouse least visit year period patients met criteria selected diabetes phenotype definitions statistically balanced sample patients selected chart review clinical experts determine presence absence type diabetes sample results sensitivity specificity ehr based type diabetes phenotypes compared gold standard ada criteria via chart review varied depending component criteria timing observations measurements discussion conclusions researchers using ehr based phenotype definitions clearly specify characteristics comprise definition variations ada criteria different phenotype definitions components impact patient populations retrieved intended application careful attention phenotype definitions critical promise leveraging ehr data improve individual population health fulfilled
one challenging issues distributed computing system reach decision presence many faulty nodes faulty nodes may update wrong information provide misleading results may nodes depleted battery power consensus algorithms help reach decision even faulty nodes every correct node decides values consensus algorithm correct nodes propose value nodes decide every correct node must agree value faulty nodes reach decision correct nodes agreed binary consensus algorithm average consensus algorithm widely used consensus algorithm distributed system apply binary consensus average consensus algorithm distributed sensor network presence faulty nodes evaluate algorithms better convergence rate error rate
purpose reviewmale hormones significantly impact man quality life recently controversy use testosterone impact man quality life controversies include testosterone effect cardiovascular disease benign prostatic hyperplasia prostate cancer fertility purpose manuscript evaluate mainly testosterone effect controversial areas well testosterone overall effect man quality life recent findingsrecent findings suggest testosterone increase man risk developing benign prostatic hyperplasia prostate cancer men low testosterone levels likely suffer cardiovascular event develop insulin resistance exogenous testosterone natural contraceptive men desiring preserve fertility use mechanisms raise natural endogenous testosterone production summaryalthough testosterone deficiency significantly impair man quality life testosterone therapy shown significantly improve many qualities depression bone mineral density energy libido erectile function muscle mass insulin resistance lower urinary tract symptoms testosterone therapy administered safely symptomatic hypogonadal men
present results clinical studies plasma infusion done late patients hypogammaglobulinemia documented short half life total allergen specific ige serum development specific allergic sensitization skin patients followed gradual decrease sensitization days also documented data included along discussion existing literature half life ige circulation skin rostrum reinterprets earlier clinical studies light new insights mechanisms could explain rapid removal ige circulation mechanisms clinical implications relate increasing use anti ige mabs treatment allergic disease
paper combines data filtering technique maximum likelihood principle parameter estimation controlled autoregressive arma autoregressive moving average systems use estimated noise transfer function filter input output data derive filtering based maximum likelihood multi innovation extended gradient algorithm estimate parameters systems replacing unmeasurable variables information vectors estimates maximum likelihood generalized extended gradient algorithm given comparison numerical simulation given support developed methods international association mathematics computers simulation imacs published elsevier rights reserved
aberrant alpha synuclein alpha syn accumulation shown impair mitochondrial function reducing mitochondrial membrane potential mmp however underlying mechanisms remain elusive transient receptor potential canonical trpc channels diverse group non selective channels among trpc one localized mitochondria plays role maintaining normal mmp raises possibility altered trpc expression may play role mitochondrial dysfunction induced alpha syn accumulation demonstrate possibility first examined expressions mitochondrial trpc brains aging monkeys alpha syn transgenic wild type mice showed alpha syn levels increased mitochondria age dependent manner positively correlated elevation mitochondrial trpc correlation prominent striatum cerebellum possibly due greater age dependent alpha syn accumulation striatum cerebellum used primary neurons overexpressing alpha syn investigate effect alpha syn induced elevation mitochondrial trpc mmp apoptotic cell death found neurons overexpressed alpha syn increased mitochondrial trpc decreased mmp accompanied increased number apoptotic neurons suppressing trpc expression partially reversed reduction mmp alleviated apoptotic cell death indicating mitochondrial trpc may play role mitochondrial dysfunction neurons alpha syn accumulation may occur aged brain also brain
recently new polynomial basis binary extension fields proposed fast fourier transform fft fields computed complexity order number points evaluated fft paper reformulate fft algorithm easier understood extended develop frequency domain decoding algorithms systematic reed solomon codes element power two first basis syndrome polynomials reformulated decoding procedure new transforms applied decoding procedure fast extended euclidean algorithm developed determine error locator polynomial computational complexity proposed decoding algorithm improving upon best currently available decoding complexity reaching best known complexity bound established justesen however justesen approach codes specific fields apply cooley tukey ffts revealed computer simulations proposed decoding algorithm times faster conventional one code
low impact development lid attracted growing attention important approach urban flood mitigation studies evaluating lid performance mitigating floods focus changes peak flow runoff volume paper assessed performance lid practices mitigating flood inundation hazards retrofitting technologies urbanized watershed nanjing china findings indicate lid practices effective flood inundation mitigation watershed scale especially reducing inundated areas high flood hazard risk various scenarios lid implementation levels reduce total inundated areas areas high flood hazard level permeable pavement shows better performance rainwater harvesting mitigating urban waterlogging efficient scenario combined rainwater harvesting rooftops cistern capacity permeable pavement installed non busy roads impervious surfaces inundation modeling effective approach obtaining information necessary guide decision making designing lid practices watershed scales elsevier ltd rights reserved
backgroundchronic postherniorrhaphy inguinal pain cpip complex major health problem absence recurrence meshoma laparoscopic retroperitoneal triple neurectomy lrtn emerged effective surgical treatment cpip methodsthis prospective pilot study evaluated neurophysiological clinical effects lrtn ten consecutive adult cpip patients unilateral predominantly neuropathic inguinodynia underwent three comprehensive quantitative sensory testing qst assessments preoperative immediate postoperative late postoperative pain severity health related function sleep quality assessed course month follow period resultsqst revealed marked increases mechanical pressure thermal pain thresholds areas maximum pain prior lrtn surgery immediate mean minutes range minutes extubation late postoperative mean days range days surgery assessments compared baseline wind phenomena eliminated postoperatively lrtn provided robust group level improvements clinical measures preoperative qst variables found predictive surgical outcomes positive change heat pain threshold preoperative compared late postoperative showed significant positive correlations improvements pain scores function conclusionslrtn may produce immediate profound consistent positive effects across multiple mechanical pressure thermal qst variables marked improvements clinical outcomes selected cpip patients data contribute understanding mechanisms involved success lrtn large high powered studies warranted determine whether preoperative repeated longitudinal qst may guide patient selection predict effectiveness lrtn
texture synthesis well established area many important applications computer graphics vision however despite success synthesis techniques used widely practice creation good exemplars remains challenging extremely tedious paper introduce unsupervised method analyzing texture content across multiple scales automatically extracts good exemplars natural images unlike existing methods require extensive manual tuning method fully automatic allows user focus using texture palettes derived images rather manual interactions dictated needs underlying algorithm natural textures exhibit patterns multiple scales may vary according location non stationarity handle textures many synthesis algorithms rely analysis input guidance synthesis new analysis based labeling texture patterns multi scale unsupervised patterns labeled multiple scales scales number labeled clusters selected automatically method works two stages first builds hierarchical extension superpixels second labels superpixels based random walk graph similarity superpixels nonnegative matrix factorization label maps provide descriptors pixels regions benefit state art texture synthesis algorithms show several applications including guidance non stationary synthesis content selection texture painting method designed treat large inputs scale many megapixels addition traditional exemplar inputs method also handle natural images containing different textured regions
paper higher order nonlinear schrodinger maxwell bloch system optical fiber communication investigated virtue generalized darboux transformation higher order rogue wave solutions derived wave propagation interaction analyzed frequency affects number troughs type propagation direction rogue waves polarization resonant medium extant population inversion frequency influence module complex envelope field frequency affects type higher order rogue wave interaction second third order rogue wave head interactions presented propagation direction rogue wave unvaried interaction
water quality early warning system mainly used detect deliberate accidental water pollution events water distribution systems identifying types pollutants necessary detecting presence pollutants provide warning information pollutant characteristics emergency solutions thus real time contaminant classification methodology uses multi classification support vector machine svm proposed study obtain probability contaminants belonging category svm based model selected samples indistinct feature mostly low concentration samples support vectors thereby reducing influence concentration contaminants building process pattern library new sample points classified corresponding regions constructing classification boundaries support vector experimental results show multi classification svm based approach less affected concentration contaminants establishing pattern library compared cosine distance classification method moreover proposed approach avoids making single decision classification features unclear initial phase injecting contaminants
images photometric data lunar reconnaissance orbiter camera lroc narrow angle cameras nacs used investigate regions moon inferred previous remote sensing compositional studies associated nonmare silicic volcanics specifically lroc nac imagery photometry normalized account local slopes using nac digital terrain models dtm used investigate exposed areas associated compton belkovich volcanic complex cbvc hansteen alpha volcanic complex havc lassell massif gruithuisen domes ejecta aristarchus crater photometric studies spacecraft landing sites ground truth compositional data exist allow study relationship photometric properties soils mineralogical chemical compositions silicic regions high reflectance single scattering albedos consistent different proportions highly reflective minerals including alkali feldspar quartz low concentrations mafic minerals silicic sites studied cbvc highest reflectance values single scattering albedos silicic pyroclastic deposits may also occur cbvc present evidence laboratory spectra addition similar glassy silicic materials highlands type regolith simulant account increased reflectance volcanic regions reflectance variations across within sites explained mixing felsic mineral components evolved intermediate silicic compositions andior silicic pyroclastic deposits elsevier inc rights reserved
new imaging techniques enable visualizing analyzing multitude unknown phenomena many areas science high spatio temporal resolution rapidly growing amount image data however hardly analyzed manually thus future research focus automated image analysis methods allow one reliably extract desired information large scale multidimensional image data starting infrastructural challenges present new software tools validation benchmarks processing strategies help coping large scale image data presented methods illustrated typical problems observed developmental biology answered using time resolved microscopy images
study examined differences adults autism spectrum disorder asd typical community volunteers measures stressful life events perceived stress biological stress response cardiovascular cortisol reactivity novel social stress task additional analyses examined relationship stress social functioning measured social adjustment scale waisman activities daily living scale results indicated adults asd experienced significantly stressful life events perceived stress greater systolic blood pressure reactivity typical community volunteers results also indicated perceived stress stressful life events significantly associated social disability interventions targeting stress management might improve social function adults asd
background address problem translation research based evidence routine healthcare practice collaboration leadership applied health research care nottinghamshire derbyshire lincolnshire clahrc ndl funded national institute health research one nine clahrcs across england paper outlines underlying theory application clahrc ndl adopted case example might generalised practice outside clahrc comparison alternative models implementation discussion conventional approaches health research frequently generate evidence isolation environment intended use premise clahrc ndl model barriers implementation overcome knowledge produced academic clinical service staff taking account organisational context applied approach founded organisational learning theory recognising change social political phenomenon evidence produced real time taking full account environment implemented support process senior health service staff seconded clahrc diffusion fellows dfs actively bridge research practice gap full member research team area clinical practice facilitate innovation embed change local health community existing communities practice enhanced new ones fostered around specific themes approach adopted clinical research studies areas mental health children young people primary care stroke rehabilitation summary clahrc ndl model implementation applies organisational learning theory addressing social situational barriers enablers implementation adopting philosophy production two key mechanisms translation innovation utilised dfs actively bridge research practice gap communities practice underpin sustain improvements healthcare model shows promising results putting research practice may transferable healthcare contexts
study conducted prenatal development testis goat embryo foeti categorized group days group days group iii days group days group days till birth embryos foeti group genital ridge observed days gestation contained accumulation mesenchymal cells immature rbc differentiating fibroblasts primordial germ cells formation sex cords evidenced day gestation contained small mesenchymal cells large cells arranged chain like manner convolution sex cords started days gestation increased increase gestation period day gestation sex cords attained form reverse question mark sustentocytes sertoli cells observed among small cells sex cords day gestation tunica albuginia appeared beneath germinal epithelium day gestation consisted layers mesenchymal cells fibroblasts small capillaries thickness tunica albuginia increased increase age foetus days gestation outer thick fibrous inner thin vascular layer could demarcated separately mesenchymal cells start differentiating interstititial endocrine cells leydig cells located interstitial spaces day gestation
australians become convinced existence locally acquired lyme disease history since recognition early reviewed model investigative approaches unknown syndromes australian management guidelines include requirement diagnostic testing national association testing authorities accredited laboratories using therapeutic goods administration licensed tests result efficient diagnosis overseas travellers despite patients left australia pay many thousands dollars non specialist consultations testing overseas laboratories unproven long term therapy multiple antibiotics resulted serious complications including allergies line sepsis pancreatitis pseudomembranous colitis studies shown vectors found australia lyme borrelia found australian vectors animals patients autochthonous illnesses propose noncontroversial name chronic syndrome adopted australian multisystem disorder research funding enable development consensus case definition studies epidemiology syndrome laboratory investigations identify aetiology surrogate markers disease prospective randomised treatment studies could undertaken using ethical protocols
paper present numerical solution method based taylor matrix method give approximate solution bagley torvik equation given method transformed bagley torvik equation system algebraic equations algebraic equations solved assistance maple coefficients generalized taylor series obtain approximate solution terms generalized taylor series numerical examples given illustrate establish accuracy reliability proposed algorithm
background unconfirmed beta lactam allergy significant public health problem limitations imposes drug selection study aimed evaluate patients referred beta lactam allergy determine frequency confirmed beta lactam allergy identify risk factors methods prospective cohort study referred patients immunology asthma allergy research institute tehran university medical sciences suspected beta lactam allergy entered study based inclusion criteria follow performed years final diagnosis diagnosis beta lactam allergy relies thorough history specific ige measurements immunocap skin prick testing spt intradermal testing idt patch testing oral drug challenge test results fifty one patients mean age years enrolled study based workups beta iactam allergy confirmed patients suspicious patients ruled patients follow patients suspicious drug allergy consumed culprit drug reaction allergy finally ruled patients age sex atopy family history drug allergies significantly different patients confirmed ruled diagnosis penicillin amoxicillin allergy conclusion least one third patients history beta lactam allergy proven safe using drug also clear protocol consists serum sige assay spt helpful physicians health care system
era condensed treatment managed care three trends gaining prevalence graduate training programs circles practicing community limiting clinicians utilizing therapeutic techniques needed help client achieve long standing intrapsychic change precondition maintaining therapeutic gains post treatment first trend equation empathy sympathy hinders therapeutic dyad truly understanding client internal experience implicitly conveys message anxiety provoking material less welcome consulting room second trend prizing cognition affect results primary focus secondary thought process discounting affective experience unconsciously steers behavior thought trend large part due widespread dissemination cognitive behavioral therapy efficacy research belief individuals psychodynamic forms treatment lack empirical support last problematic trend rigid utilization treatment manuals tends result reductionistic approach treatment limiting psychotherapy set techniques also overlooking salient aspects treatment predict positive outcomes treatment manuals oversimplify process therapy result therapeutic dyad less likely uncover discover multiple origins one suffering contributory factors always readily available conscious awareness paper discusses trend therapeutic implications result
suggested serotonergic hypofunction serotonergic pathway genes underlie somatic symptoms somatoform disorders examined variety serotonin related gene polymorphisms determine whether undifferentiated somatoform disorder associated specific serotonin related gene pathways serotonin related polymorphic markers assessed using single nucleotide polymorphism snp genotyping one hundred two patients undifferentiated somatoform disorder healthy subjects enrolled genotype allele frequencies tryptophan hydroxylase tph tph serotonin receptor htr htr serotonin transporter httlpr gene compared groups hamilton rating scale depression somatization subscale symptom checklist revised scl used psychological assessment patients undifferentiated somatoform disorder higher frequencies tph allele healthy controls difference significant bonferroni correction frequency tph genotype also differ significantly patients healthy controls tph htr htr httlpr allele genotype frequencies differ significantly two groups findings suggest variety serotonin related gene pathways unlikely definite genetic risk factors undifferentiated somatoform disorder therefore pathogenesis disorder may related epigenetic factors including psychosocial cultural factors nonetheless future studies need include larger sample subjects polymorphisms serotonin related gene variants elsevier ireland ltd rights reserved
paper presents solutions provided abb station service voltage transformer ssvt power source effectively enables rural community access electricity high voltage transmission grid typical community electrification applications consist construction electrical network infrastructures requiring higher investment space longer duration alternative solution developed abb apply ssvt product serve mini substation stepping power supply directly high voltage transmission line low voltage medium voltage output one step provide power source small residential areas without large investment rough estimations indicate using ssvt rural electrification reduce cost much traditional substation abb continuously developed new different technological solutions global humanitarian challenges access electricity one recent project abb power systems abb high voltage power products coordinated delivering units ssvt supply power rural villages democratic republic congo congo project funded world bank project focused changing people lives villages help fight poverty
existing pid parameters tuning methods effective pre known accurate system models often require strict identification experiments thus infeasible many complicated systems actually practical engineering applications desirable pid tuning scheme directly based input output response closed loop system thus new parameter tuning scheme pid controllers without explicit mathematical model developed paper paper begins new frequency domain properties analysis pid controller definition characteristic frequency pid controller given order study mathematical relationship pid parameters open loop frequency properties controlled system concepts field theta field introduced used explain pid control parameters influence closed loop frequency magnitude property time responses subsequently new pid parameter tuning scheme group tuning rules proposed based preceding analysis finally simulations experiments conducted results verify feasibility validity proposed methods research proposes pid parameter tuning method based outputs closed loop system
artificial neural networks ann known ability solve classification optimization tasks applied many fields communications equalization multiuser detection among others paper analog realization iterative threshold decoding binary linear codes presented shown iterative threshold decoding algorithm matches well structure continuous high order recurrent neural network performance analog realization evaluated simulation compared corresponding digital realisation motivation work analog decoding improves power speed ratio minimizes area consumption large scale integration vlsi chip
concept family planning originated birth control control size family prevent unplanned pregnancies transformed family welfare later expanded horizons reproductive child health rch wide spectrum choices male female temporary permanent developed offered developed world stabilised population faces problem teenage adolescent pregnancies developing nations still struggling stabilise population traditionally depend permanent female sterilisation major method contraception lot unmet need seen young recently married women post delivery post abortal states long acting reversible contraception includes intrauterine device iud implants emerged strongly first choice contraception women ages including unmarried teenage pregnancies highly efficient failure rates equivalent better permanent methods cost effective reversible potential replace permanent sterilisation
multigranulation rough set theory relatively new mathematical tool solving complex problems multigranulation distributed circumstances characterized vagueness uncertainty paper first introduce multigranulation approximation space according idea fusing uncertain imprecise information present three uncertainty measures fusing information entropy fusing rough entropy fusing knowledge granulation multigranulation approximation space furthermore several essential properties equivalence maximum minimum examined relationship fusion information entropy fusion rough entropy also established finally prove three measures monotonously increasing partitions become finer results helpful understanding essence uncertainty measures multigranulation rough space enriching multigranulation rough set theory
current study sought assess content validity internal consistency peak generalization module eighty four children autism evaluated using peak generalization assessment ascertain presence absence language learning skills within child repertoire following assessment principal component analysis run yielding four component model peak generalization module specifically components possessing eigenvalues greater least one item strongly correlated retained items sorted various components based correlation scores within rotated component matrix generated principal component analysis following establishment four component model internal consistency model tested using cronbach alphas indicated strong internal consistency overall peak assessment well four underlying components four components identified include constructs foundational learning basic social skills basic verbal comprehension memory advanced social skills advanced verbal comprehension reading writing basic problem solving skills verbal reasoning problem solving logic mathematical skills increased demand evidence based intervention number individuals diagnoses autism rises present data provide support conceptually systematic behavior analytic approach treatment children autism
paper presents design simulation high performance brain emotional learning fuzzy based intelligent controller belfbic three phase induction motors speed control belfbic improved version brain emotional learning based intelligent controller belbic controller control simple relatively easy implement provides motor performance adequate applications first time belfbic used space vector pulse width modulation inverter fed induction motor speed control comparative analysis proportional integral derivative pid controller belbic also carried simulation conducted matlab simulink proposed controller implemented hardware performance shown better either pid belbic
background army recruit required complete variety strenuous physical activities training activities potential cause range injuries purpose aim study determine length recruit training program influenced injury rates materials methods data obtained australian regular army recruits attended basic recruit training completing either day australian recruit course arc day australian soldier course asc injury prevalence injury incidence determined following analysis reported injury data incident report form results injury prevalence asc recruits arc recruits injury incidence asc arc injuries soldiers days injuries soldiers days respectively majority injuries courses sprains strains discussion asc notably higher prevalence injuries compared arc however considered cohort size exposure training courses similar injury incidence rates study found much lower prevalence incidence rates reported previous literature basic recruit training injury types however consistent previous literature conclusions potentially appearing increase reported injuries longer tactical recruit training programs may influence incidence injuries cohort size length training considered types injuries suffered australian army recruits undergoing training commensurate foreign defence services
work focus development multiscale modeling run run control framework purpose improving thin film product quality batch batch plasma enhanced chemical vapor deposition pecvd manufacturing process specifically macroscopic scale gas phase reaction transport phenomena yield deposition rate profiles across wafer surface provided microscopic domain simulator complex microscopic surface interactions lead film growth described using hybrid kinetic monte carlo algorithm batch batch variability prompted development additional simulation layer exponentially weighted moving average ewma control algorithm operates serial batch deposition sequences adjust operating temperature pecvd reactor overcome drift electron density plasma application run run control system developed shown reduce offset product thickness less within batches reactor operation finally propose extension ewma algorithm four independent radial wafer zones order improve thickness uniformity presence spatially non uniform species concentrations demonstrated produced thin films driven desired thickness set point less batches presence electron density drift non uniform deposition rate profiles elsevier ltd rights reserved
background mental skills training refers implementation cognitive performance enhancing strategies promote optimal performance aimed develop surgery specific mental skills curriculum msc obtain initial evidence efficacy methods developed msc consisted proven performance enhancing modules efficacy assessed laparoscopic simulator based practice novices using validated instruments mental skills workload stress addition skill transfer test porcine model paired test used analyze data results nine surgical novices completed curriculum compared baseline assessment participants improved significantly laparoscopic performance mental skills completion msc participants completed task porcine model without appreciable change perceived stress skill transfer test participants observed using mental skills taught msc conclusions surgery specific simulator based msc developed efficacy improving mental skills surgical performance supported surgical skill transfer test elsevier inc rights reserved
recent years green building construction earning significant place singapore construction industry success green building project inevitably associated leadership project manager study attempts identify leadership characteristics styles project managers singaporean green building projects conducting questionnaire survey project managers experienced green construction study identified leadership characteristics among strive work performance productivity ranked top additionally characteristics categorized two groupings directive task oriented leadership relationship oriented leadership results indicated leadership style project managers towards directive task oriented leadership overlook relationships subordinates therefore study provides understanding leadership characteristics styles project managers green building projects practitioners researchers
piston ring pack important sealing combustion chamber internal combustion engine plays major role friction wear oil consumption considerations experimental theoretical studies area difficult due complexity highly dynamic system paper deals numerical investigation means computational fluid dynamics gas oil flow piston ring pack validated experimental data simulation results show gas oil transport mechanisms used improve existing models simulations leads better understanding processes piston ring pack helps optimize tribological system elsevier ltd rights reserved
investigate patient reported multidimensional gastrointestinal symptoms predictors generic health related quality life hrqol pediatric patients functional gastrointestinal disorders fgids pediatric quality life inventory pedsql gastrointestinal symptoms scales pedsql generic core scales completed site study pediatric patients functional constipation functional abdominal pain fap irritable bowel syndrome ibs gastrointestinal symptoms scales measuring stomach pain stomach discomfort eating food drink limits trouble swallowing heartburn reflux nausea vomiting gas bloating constipation blood poop diarrhea identified clinically important symptom differentiators healthy controls based prior findings subsequently tested bivariate multivariate linear associations overall hrqol gastrointestinal symptoms differentially associated decreased hrqol bivariate analyses three fgids predictive models utilizing hierarchical multiple regression analyses controlling age gender race ethnicity gastrointestinal symptoms differentially accounted additional variance patient reported hrqol functional constipation fap ibs respectively reflecting large effect sizes significant individual gastrointestinal symptoms predictors identified controlling gastrointestinal symptoms fgid specific predictive models gastrointestinal symptoms represent potentially modifiable predictors generic hrqol pediatric patients fgids identifying condition specific gastrointestinal symptoms important predictors patient perspective facilitates patient centered approach targeted interventions designed ameliorate impaired overall hrqol
backgroundpatients myeloproliferative neoplasms mpns including polycythemia vera essential thrombocythemia myelofibrosis faced oppressive symptom profiles compromise daily functioning quality life among symptoms sexuality related symptoms emerged particularly prominent largely unaddressed current study authors evaluated sexuality symptoms mpn relate patient characteristics disease features treatments symptoms methodsa total patients mpn essential thrombocythemia polycythemia vera myelofibrosis classified prospectively evaluated patient responses myeloproliferative neoplasm symptom assessment form mpn saf european organization research treatment cancer quality life questionnaire core eortc qlq collected along information regarding individual disease characteristics laboratory data sexuality scores compared age matched healthy control population resultsoverall patients mpn found greater sexual dysfunction compared healthy population mpn saf score years cytopenias transfusion requirements receiving certain therapies immunomodulators steroids conclusionsthe results current study identify topic sexuality prominent issue mpn population area would appear benefit additional investigation management cancer american cancer society sexuality problems impact domains functionality depression microvascular symptoms overall quality life among patients myeloproliferative neoplasms problems correlate patient age presence cytopenias transfusion requirements common therapies myeloproliferative neoplasms see also pages
congenital dyserythropoietic anemia type cdai rare autosomal recessive disease characterized macrocytic anemia ineffective erythropoiesis secondary hemochromatosis better define natural history disease among adult patients studied bedouin patients median age range carrying cdan founder mutation follow studies included complete blood count blood chemistry abdominal ultrasound echocardiography mri main complications due anemia ineffective erythropoiesis osteoporosis cholelithiasis pulmonary arterial hypertension pah iron overload hypothyroidism diabetes mellitus mri revealed increased liver iron cardiac iron anemia improved majority patients underwent splenectomy three patients died age due pah sepsis previously underwent splenectomy analyzing patients patients previously described heimpel blood conclude adults cda suffer significant morbidity mortality careful monitoring iron overload prompt iron chelation therapy mandatory due possible complications inconsistent response splenectomy alpha interferon transfusion therapy stem cell transplantation considered alternatives procedure severely affected patients
three dimensional representations urban regions gained much attention recent developments remote sensing computer graphics technologies particular textured building reconstruction variety applications popular research topic recent years study present reconstruction building models along texture selection mapping extracted two dimensional building patches normalized digital surface model ndsm data used generate models build near photorealistic models acquired geo referenced facade textures associated corresponding building facades using automated gps assisted approach hand modelling texture mapping roof structures carried manually study area composed eight housing estates blocks total buildings analysed whole study area modelled facade textures less min processor running time acceptable level accuracy texture mapping carried using matlab virtual reality toolbox
aims urinary incontinence general major cause quality life impairment morbidity hospitalization onset strongly linked menopause study aimed elucidate possible relationship endogenous circulating estrogens onset development stress urinary incontinence sui methods one hundred thirty eight peri postmenopausal women sui matched continent women based age bmi morning fasting blood samples drawn subjects assessment estradiol fsh testosterone delta androstendione dheas prolactin sbhg well biochemical profile glucose insulin triglycerides cholesterol hdl ldl apoa apob hormone biochemical parameters compared continent incontinent women results incontinent women significantly lower serum estradiol levels compared control group furthermore association observed serum associations remained significant controlling age menopausal age bmi number deliveries conclusions results may indicate within postmenopausal range endogenous sex hormones may associated presence sui women menopausal hormone therapy wiley periodicals inc
purpose increased body mass index bmi associated brain atrophy gray white matter structures however little known concerning integrity white matter tracts obesity purpose study evaluate pattern changes white matter microstructure human adiposity material methods study included participants obese overweight normal weight retrospectively evaluated diffusion tensor imaging fractional anisotropy axial radial mean diffusivity values compared groups using tract based spatial statistics results analysis revealed increased bmi related decreased fractional anisotropy several white matter regions including anterior posterior thalamic radiation inferior fronto occipital fasciculus inferior superior longitudinal fasciculus corpus callosum callosal body forceps minor uncinate fasciculus internal capsule corticospinal tract cingulum cingulate gyrus hippocampus conclusions anisotropic diffusion anatomic regions governing important brain circuits reward seeking inhibition motivation drive learning conditioning decreases increasing bmi elsevier inc rights reserved
background nonalcoholic fatty liver disease nafld diagnosed early noninvasive ultrasonography however cost effectiveness ultrasonography screening intensive weight reduction program metabolic syndrome patients clear study aims estimate economic clinical outcomes ultrasonography thailand methods cost effectiveness analysis used decision tree markov models estimate lifetime costs health benefits societal perspective based cohort metabolic syndrome patients thailand data obtained published literatures thai database results reported incremental cost effectiveness ratios icers dollars usd per quality adjusted life year qaly gained discount rate sensitivity analyses performed assess influence parameter uncertainty results results icer ultrasonography screening year old metabolic syndrome patients intensive weight reduction program usd qaly gained compared screening probability cost effective using willingness pay threshold thailand usd qaly gained screening years cost saving screening years cost effective conclusions patients metabolic syndromes ultrasonography screening nafld intensive weight reduction program cost effective program thailand study used part evidence informed decision making translational impacts findings could contribute changes nafld diagnosis practice settings economic evidence used part decision making process furthermore study design model structure input parameters could also used future research addressing similar questions
recently specific attention paid aptamers short dna rna tool cancer diagnosis therapy present study mcs nanogels prepared myristate chitosan ratio characterized several techniques selected ssdna aptamer apt capable detecting lncap cells linked myristilated chitosan nanogels apt mcs glutaraldehyde loaded doxorubicin dox used targeted drug delivery prostate cancer cells lncap cells treated apt mcs dox complex binding efficiency estimated flow cytometry binding affinity selected aptamers compared initial library loading capacity nanogel high dox released mcs within days cytotoxicity nanodrug lncap cells determined mtt assay apt mcs dox specifically binded lncap cells whereas show specificity cells negative control mcs dox apt mcs dox showed lethal effect lncap cells results lead aptamer based simple applicable technique early diagnosis treatment cancerous cells
aims objectives explore hospice acute care nursing home nurses experiences pain management people advanced dementia final month life identify challenges facilitators practice areas requiring support background pain management end stage dementia fundamental aspect end life care however unclear challenges facilitators nurses experience practice whether differ across care settings whether training needs tailored context care design qualitative study using semi structured interviews thematic analysis examine data methods twenty four registered nurses caring people dying advanced dementia recruited nursing homes three hospices two acute hospitals across region interviews conducted june september results three core themes identified challenges administering analgesia nurse physician relationship interactive learning practice development patient related challenges pain management universal across care settings nurse organisation related barriers differed settings need interactive learning practice development particularly pharmacology identified conclusions achieving pain management practice highly challenging number barriers identified however manner extent impacted nurses differed across hospice nursing home acute care settings needs based training support promote practice development pain management end stage dementia required relevance clinical practice nurses considered pain management fundamental end life care provision however nurses working acute care nursing home settings may undersupported resourced adequately manage pain people dying advanced dementia nurse nurse mentoring ongoing needs assessed interactive case based learning could help promote practice development area nurses require continuing professional development pharmacology
increasingly anthropogenic perturbations biosphere manifest broad array global phenomena causing widespread contamination ecosystems high dispersion rates many contaminants throughout different environmental compartments including metals chromium contamination particular increasingly posing serious threat environment emerging major health hazard biota however although molecular physiological mechanisms plant responses many heavy metals especially lead cadmium focused upon recent years chromium attracted significantly less attention context review discusses aspects uptake transport physiological biochemical effects exposure plants molecular defense mechanisms metal recent advances determining responses fields knowledge genomics proteomics metallomics discussed herein
report case paradoxical presentation postural postdural puncture headache secondary dural puncture gauge whitacre needle combined spinal epidural anesthesia year old female patient presented emergency department elevated blood pressure global headache days administration epidural anesthesia spontaneous vaginal delivery uncomplicated pregnancy patient reported headache intense lying immediately improved sat stood recumbent position patient discharged emergency depai tuient improvement following treatment labetalol ondansetron ketorolac fluid resuscitation published elsevier inc
objective personal care products cosmetics substances various chemical contents whose reliability exactly known enough study demonstrate safety use pregnancy purpose study demonstrate usage frequency personal care products cosmetics methods cross sectional study pre prepared questionnaire filled pregnant women questionnaire sociodemographic characteristics participants usage frequency cosmetics personal care products evaluated different categories results study frequently used products pregnancy general hygiene products toothpaste shampoo soap hand cream wet wipes shower gel hair conditioner moisturizer use following products respectively evaluated according education levels found usage hair dye powder foundation primary school graduates significantly higher university graduates use sun protection products fair skin types found significantly higher dark ones conclusion study reveals personal care products cosmetics used often pregnancy data provide exposure studies associated cosmetic use pregnancy planned accurately
objective objective study explore effects reactive oxygen species ros hypoxic environment prostatic stromal cells psc methods materials detect expression ros psc tissues benign prostatic hyperplasia bph flow cytometry hypoxic conditions observe changes cells growth ros psc quantitative pcr used detect hypoxia inducible factor alpha hif alpha androgen receptors vascular endothelial growth factor vegf interleukin psc edaravone intervening examine changes cells growth ros hif alpha vegf hypoxic conditions results expression ros tissues cells hypoxic condition significantly increased promoted proliferation hif alpha vegf upregulated edaravone intervening ros significantly decreased hif alpha vegf downregulated cell proliferation declined conclusions hypoxia stimulates generation ros ros may play key role bph
use smart devices increasing rapidly trend changing paradigm notifications delivered users smart devices important provide user awareness however use must controlled human perception considered avoid information overload paper present dynamic mechanism coordinate distribution notification across smart devices personalized notification mechanism uses inference engine set rules generate notification alternatives select best one continuous refinement approach also used improve notification delivery system evaluated baseline rules established expert users main results show scenarios notification mechanism selection converged quickly results promising however work required provide personalized integrated one device time notification management
tris triazolyl borate ttz proton responsive ligand redox potential ttz complexes altered protonation protonation events therefore alter thermodynamics reduction copper complexes relevant nitrite reduction mediated copper complexes wherein reduction first step electrochemical behavior tris triazolyl borate corresponding copper complexes ttz tbu cuci ttz tbu cuno investigated neutral acidic conditions upon protonation reduction shifted positive delta upon addition equiv acid result indicates ligand protonation facilitates reduction process also evident vis spectral data contrast ttz tbu cuno analog reduction peak shifted towards negative potential vis spectra shows significant changes acid added suggests protons may involved assisting redox process rather lead decomposition events reducing potentials electrochemical control studies series compounds namely ttz tbu znci ttz tbu ttz tbu htz tbu also conducted without acid present studies shown triazole rings metal complexes redox active conditions used therefore conclude ttz ligand including site reduction studies elsevier rights reserved
several single gene disorders potentially overlooked differential diagnostic evaluation patients multiple sclerosis pelizaeus merzbacher disease spastic paraplegia type allelic linked disorders associated defective myelination central nervous system mutations plp neurological symptoms occasionally observed female carriers mutations two women proposita mother reported walking difficulties since adolescence showed progressive cognitive decline neurological examinations revealed spastic gait pyramidal tract involvement distal muscle atrophy legs peripheral neuropathy diffuse white matter changes brain mri also observed patients preliminary diagnosis primary progressive using targeted method next generation sequencing novel heterozygous plp identified mutation also found five healthy relatives mutation showed moderate severe skewed inactivation tissues western blotting revealed significant reduction plp sural nerve conclusion mother daughter presented linked dominant disorder skewed inactivation authors suggest plp testing might considered evaluation women spastic paraparesis cognitive decline changes elsevier rights reserved
worldwide natural gas consumption increased significantly especially power generation electricity systems gas power process natural gas fired units supply natural gas electricity systems dispatched economically simultaneously due firm interconnection paper proposes security constrained level economic dispatch model integrated natural gas electricity systems considering wind power power gas process upper level formulated optimization model electricity system lower level optimal allocation problem natural gas system natural gas system modeled detail addition security constraints coupling constraints integrated energy systems considered objective function minimize total production cost electricity natural gas lower model converted added upper model karush kuhn tucher kkt optimality conditions thus level optimization model transformed mix integer linear programming milp formulation numerical case studies pjm bus system integrated seven node gas system ieee bus system integrated modified belgian high calorific gas system demonstrate effectiveness proposed level model elsevier ltd rights reserved
refactoring large systems involves several sources uncertainty related severity levels code smells corrected importance classes smells located severity importance identified refactoring opportunities code smells difficult estimate fact due dynamic nature software development values accurately determined practice leading refactoring sequences lack robustness addition code fragments contain severe quality issues playing important role system address problem introduced multi objective robust model based nsga software refactoring problem tries find best trade three objectives maximize quality improvements severity importance refactoring opportunities fixed evaluated approach using open source systems one industrial project demonstrated significantly better state art refactoring approaches terms robustness experiments based variety real world scenarios suggested refactoring solutions found comparable terms quality suggested existing approaches better prioritization refactoring opportunities carry acceptable robustness price
suggested left hemisphere advantages verbal processing due superior top control verbal information clear top mechanisms affect encoding retrieval verbal information hemispheric memory whether influence activation also encompass inhibition verbal information directed forgetting method conjunction divided visual field presentation used examine influence top control mechanisms hemispheric asymmetries verbal memory participants cued remember forget words cues presented either simultaneously targets short delay recognition memory test using divided visual field presentation given response times rts revealed effects cue timing simultaneous cues rts faster remember words compared forget words delayed cues rts remember forget words equivalent right hemisphere remember words consistently faster forget words regardless cue timing data provide evidence top mechanisms influenced verbal memory retrieval verbal memory retrieval finally little evidence suggest hemispheres differ inhibitory processing
laparoscopic adjustable gastric banding lagb third popular bariatric procedure worldwide various authors present ambivalent long term follow results revised records patients underwent lagb along history additional check ins patients outdated details tracked national health insurance database social media facebook online survey sent patients band removed included study calculated percent total weight loss twl percent excess weight loss ewl along changes body mass index delta bmi satisfactory weight loss set ewl bmi since eight patients gained weight decided include negative values twl ewl delta bmi one hundred seven patients underwent lagb mean follow time years eleven percent patients lost follow one perioperative death fifty four patients band removed thirty seven patients still band included study mean ewl twl twelve patients achieved ewl thiry two patients still suffer obesity bmi eight patients gained additional weight patients ewl suffered less gastroesophageal reflux disease symptoms ewl cases patients gastric band achieved satisfactory ewl twenty two percent patients regained weight even exceeded overall results suggest lagb effective bariatric procedure long term observation
sensor node applications auxiliary power drawn mains supply mixed signal sensor components therefore need low cost sub miniature non isolated converters work new two chip architecture proposed implement high voltage quasi resonant buck converter peak current mode control current voltage control loops implemented high side low side respectively includes power transistor sensing control circuits transmits digital peak current command along mode selection information using low power mhz isolated communication interface architecture achieves peak simulated efficiency converting allows size input filter greatly reduced due current mode operation state art uhv bcd technologies offer unique opportunity increase level integration reduce system cost targeted sensor node applications despite relatively poor figure merit devices compared discrete silicon super junction gan alternatives
brief presents submicrowatt offset free implantable system biomedical capacitive sensor system powered mhz radio frequency signal performs sensor signal amplification analog digital conversion load shift keying uplink data transmission within ultralow power capacitance digital converter cdc designed replacing power hungry operational amplifier subthreshold inverter switched capacitor amplifier amp fast response gain compensation method employed reduce gain error amp achieving high energy efficiency cdc eliminate offset two step autocalibration applied application specific integrated circuit implemented taiwan semiconductor manufacturing company complementary metal oxide semiconductor technology whole system achieves effective number bits bit linearity consuming
hashimoto encephalopathy may often present initially psychiatric symptoms presentations often variable clinical aspects systematic analysis numerous psychiatric presentations heralding eventual diagnosis guide clinicians make correct diagnosis systematic review done analyze demographic characteristics symptom typology clinical treatment variables associated forerunner presentations electronic databases pubmed sciencedirect google scholar databases searched identify potential case reports described initial psychiatric presentations english language peer reviewed journals generated articles evaluated relevant data extracted using structured tool identified total forty articles described cases half total samples age years presentation common psychiatric diagnosis heralding acute psychosis followed depressive disorders dementia schizophrenia uncommon presentations antithyroid peroxidase antibodies elevated patients antithyroglobulin antibodies preexisting hypothyroidism absent majority cases steroid doses initiated intravenous methylprednisolone majority patients oral steroid maintenance required significant minority psychiatric manifestations may heterogeneous require high index clinical suspicion especially older adults range clinical treatment variables may assist clinicians making faster diagnosis instituting prompt effective management
special attention required removal nitrogen phosphorous treated wastewaters although wide range techniques commercially available nutrient take processes entail high investment operational costs hand microalgae growth simultaneously remove inorganic constituents wastewater produce energy rich biomass among cultivation technologies high rate algae ponds hraps accepted appropriate system however optimization operation maximizes productivity nutrient removal lipid content biomass generated established study effect two levels depth addition evaluated batch essays used calculation kinetic parameters microbial growth determine optimum conditions continuous operation nutrient removal lipid content biomass generated analyzed best conditions found depth addition biomass productivity tssm lipid productivity lipids continuous mode concentration nutrients cases discharge limits established restrictive regulation wastewater discharge elsevier rights reserved
background diagnostic treatment delays increase severity transmission pulmonary tuberculosis ptb study aimed evaluate diagnostic treatment delays acid fast bacilli afb smear negative patients methods retrospective observational study patients positive afb culture mycobacterium tuberculosis complex mtc selected among hospitalised patients diagnosis pneumonia admission ward anti tuberculosis treatment duration afb culture compared smear positive smear negative patients results patients positive isolation mtc afb culture smear negative isolated hospital neither diagnosed treated contrast smear positive patients directly admitted quickly transferred isolation room started anti tuberculosis treatment samples smear negative patients required time grow mtc afb culture smear positive patients days days diabetes significantly associated afb smear positivity odds ratio conclusions negative afb smears caused significant diagnostic treatment delay patients staying general ward exposed patients diagnosed time
paper concerned problem optimal contraception control nonlinear population model size structure first existence separable solutions established crucial obtaining optimal control strategy moreover shown population density depends continuously control parameters existence optimal control strategy proved via compactness extremal sequence finally conditions optimal strategy derived means normal cones adjoint systems
men hair removal practices becoming mainstream seen consequence changing masculine norms men relationships bodies often presented straightforward shift men ideal bodies naturally hairy increased hairlessness consequence men body concerns inevitable paper analyses qualitative survey data aotearoa new zealand using critical thematic analysis describes three themes two themes capture contradictory ideas men body hair natural men body hair unpleasant third theme introduces concept excess hair allowed sense making contradiction mandating men grooming excessive hair however vagueness concept may provoke anxiety men resulting hair removal paper adds body research demonstrating cultural transition ways changing masculinities increased commodification male bodies shifting gender roles impact men hair removal practices elsevier ltd rights reserved
due diversity geographical objects makes great sense introduce multiscale segmentation representation analysis interpretation high spatial resolution remote sensing images however increasing use high resolution images traditional multiscale segmentation methods gradually show lack efficiency particularly handling large scale images paper novel bilevel scale sets model bsm proposed multiscale region based representation large scale remote sensing images bsm first image divided blocks overlapped margins low level scale sets model blockwisely implemented second segmentation result obtained retrieving mosaicking blockwise segmentation results based high level scale sets model implemented covering whole image improve efficiency bsm parallel implementation presented blockwise scale sets model experiments first effectiveness bsm validated using worldview image covering coastal area shenzhen bsm obtains accurate multiscale representation results without mosaic artifacts efficiency bsm demonstrated comparing state art multiscale segmentation method one integrated commercial software ecognition proposed bsm takes min process multispectral image two three times faster competing method
nonpharmacological treatment strategies acute musculoskeletal injury revolve around pain reduction promotion healing order facilitate return normal function activity heat cold therapy modalities often used facilitate outcome despite prevalent confusion modality heat cold use use recommendations use heat cold therapy based empirical experience limited evidence support efficacy specific modalities literature review provides information practitioners use heat cold therapies based mechanisms action physiological effects medical evidence support clinical use physiological effects cold therapy include reductions pain blood flow edema inflammation muscle spasm metabolic demand limited evidence randomized clinical trials rcts supporting use cold therapy following acute musculoskeletal injury delayed onset muscle soreness doms physiological effects heat therapy include pain relief increases blood flow metabolism elasticity connective tissues limited overall evidence support use topical heat general however rcts shown heat wrap therapy provides short term reductions pain disability patients acute low back pain provides significantly greater pain relief doms cold therapy remains ongoing need sufficiently powered high quality rcts effects cold heat therapy recovery acute musculoskeletal injury doms
objective trauma model dissociative identity disorder posits etiologically related chronic neglect physical sexual abuse childhood contrast fantasy model posits simulated mediated high suggestibility fantasy proneness sociocultural influences date two models jointly tested individuals empirical manner method study included matched groups patients controls compared psychological trauma fantasy measures diagnosed genuine simulating healthy controls individuals post traumatic stress disorder ptsd healthy controls additionally personality state dependent measures obtained neutral personality states nps trauma related personality states tps tested conclusion trauma measures group highest scores tps higher nps followed ptsd groups group fantasy prone suggestible generate false memories malingering measures inconclusive evidence consistently supported trauma model challenges core hypothesis fantasy model
high school students chemistry course challenged prepare improved lemon cake means statistical experimental design introduced basic statistical experimental design theory calculation effects empirical mathematical models response surfaces isocontour projections well descriptive statistics geogebra digital program teaching learning mathematics used produce mathematical models response surface plots assessment lemon cakes regard fluffiness texture lemon taste overall rating required efficient planning sensory panels slight extrapolation selection experimental setting outside investigated domain assessment predicted procedure check reproducibility lemon cake recipe also included project complements next generation science standard
background multiple sclerosis chronic immune mediated disease central nervous system cns although cognitive impairment affects large proportion patients data available prognostic value associated advanced magnetic resonance imaging mri metrics objectives aimed investigating relationship early disease progression year follow patients methods conducted retrospective year longitudinal study involving patients relapsing remitting completed neuropsychological examination structural mri time diagnosis patient clinically evaluated every months cortical thickness quantified baseline end follow patients classified normal cognition mild severe results results show time diagnosis good predictor conversion definite disability progression well transition secondary progressive phase cortical thinning conclusion confirmed extended evidence early might helpful identification patients high risk disability progression poor clinical outcome considered marker aggressive pathology
sleep linked host physical behavioral emotional outcomes research documented youth across globe experiencing inadequate sleep despite knowledge however little research conducted school age children much extant research focused infants toddlers preschoolers adolescents adults school age children exhibit increasing independence around health related behaviors provide health professionals opportunity educate promote healthy sleep behaviors commentary extends previous research reviews identifying current gaps sleep research highlighting future directions needed sleep research explaining school nurses best suited address growing public health issue
sorption heat storage potential store large amounts thermal energy renewables distributed energy sources article provides overview recent advancements long term sorption heat storage material prototype scales focus applications requiring heat within temperature range degrees space heating domestic hot water production industrial processes material level emphasis put solid gas reactions water sorbate particular salt hydrates adsorbents recent advancements composite materials reviewed investigated salt hydrates comply requirements safety availability low cost however hydrothermal stability issues deliquescence decomposition certain operating conditions make utilization pure form challenging adsorbents hydrothermally stable lower energy densities higher prices composite materials investigated reduce hydrothermal instabilities achieving acceptable energy densities material costs prototype scale article provides updated review system prototypes based reviewed materials open closed system layouts addressed together main design issues heat mass transfer reactors materials corrosion resistance especially open systems focus pure adsorbents rather salt hydrates active materials due better stability however high material costs desorption temperatures coupled lower energy densities typical system operating conditions decrease commercial attractiveness among main conclusions implementation within scientific community common key performance indicators suggested together inclusion economic aspects already material scale investigations authors published elsevier ltd
prevalence allergies increasing since mid twentieth century however underlying causes increase fully clear understanding mechanism harmless protein becomes allergen provides basis prevent treat diseases although studies allergen immunogenicity traditionally focused structural properties proteins increasingly clear allergenicity determined based structural features allergenic proteins fact allergens encounter human facings isolated molecules contained complex mixtures proteins carbohydrates lipids pollen grains foods result attention lately directed examine whether allergen associated molecules exhibit immune regulatory properties present review aims illustrate examples non protein molecules accompanying allergen modulate allergic responses
several recent commentaries suggested possible researcher bias part scientists conducting studies find evidence causal link violent video game play aggression present article argues patterns authorship publication research findings within experimental violent video game aggression literature inconsistent researcher bias hypothesis concluded claim causal link violent video game play aggression defensible interpretation current experimental meta analytic literatures elsevier ltd rights reserved
objective compare efficacy terms disease control survival advanced hypopharyngeal laryngeal lesions according treatment strategy primary surgery primary chemoradiotherapy crt invasion pattern cartilage cai soft tissue involvement sti methods records patients carcinoma cai sti treated university clinic years retrospectively reviewed results disease specific survival dss cai group crt sti group respectively overall survival sti crt cai crt respectively positive resection margins regional neck metastases reduced survival lesions treated non operatively still significantly improved survival versus conclusion surgery remains indispensable part treatment local advanced hypopharyngeal laryngeal cancer high survival results part concept includes adjuvant lesions primary crt also acceptable cai contraindication primary crt regional disease strong prognostic factor spite adjuvant treatment dss deteriorates cases positive resection margins elsevier ireland ltd rights reserved
background subclinical hypothyroidism sch common condition elderly people defined elevated serum thyroid stimulating hormone tsh normal circulating free thyroxine evidence lacking effect thyroid hormone treatment describe protocol large randomised controlled trial rct levothyroxine treatment sch methods participants community dwelling subjects aged years sch diagnosed elevated tsh levels three months apart levels within laboratory reference range study randomised double blind placebo controlled parallel group trial starting levothyroxine micrograms daily micrograms subjects body weight known coronary heart disease titration dose active treatment group according tsh level mock titration placebo group primary outcomes changes two domains hypothyroid symptoms fatigue vitality thyroid related quality life questionnaire thypro one year study power tailed detect change levothyroxine treatment hypothyroid scale fatigue vitality scale total target sample size patients secondary outcomes include general health related quality life euroqol fatal non fatal cardiovascular events handgrip strength executive cognitive function letter digit coding test basic instrumental activities daily living haemoglobin blood pressure weight body mass index waist circumference patients monitored specific adverse events interest including incident atrial fibrillation heart failure bone fracture discussion large multicentre rct levothyroxine treatment subclinical hypothyroidism powered detect clinically relevant change symptoms quality life likely highly influential guiding treatment common condition
shape memory alloy sma actuators integrated pulley system provide mechanical advantage reduce packaging space however appears formal investigation effect pulley system sma structural functional fatigue work cyclic testing conducted nickel titanium niti sma actuators pulley system control experiment without pulley structural functional fatigues monitored fracture maximum cycles achieved experimental condition taguchi method analysis variance anova used optimise sma pulley system configurations general one way anova confidence level showed significant difference structural functional fatigue sma pulley actuators sma actuators without pulley within sample sma pulley actuators effect activation duration greatest significance structural functional fatigue pulley configuration angle wrap sheave diameter greater statistical significance load magnitude functional fatigue work identified structural functional fatigue performance sma pulley systems optimised maximising sheave diameter using intermediate wrap angle minimal load activation duration however parameters may compatible commercial imperatives test completed commercially optimal sma pulley configuration novel observation applicable many areas sma pulley system applications development
progressive relatively circumscribed loss semantic knowledge referred semantic dementia falls broader umbrella frontotemporal dementia officially identified clinical syndrome less years ago review recent neuroimaging pathological genetic research neuroimaging perspective characterised hallmark asymmetrical atrophy anterior temporal pole anterior fusiform gyrus usually left lateralised functional magnetic resonance imaging fmri studies revealed widespread changes connectivity implicating anterior temporal regions semantic deficits task related fmri also demonstrated relative preservation frontal parietal regions alongside preserved memory performance addition recent longitudinal studies demonstrated disease progression atrophy encroaches contralateral temporal pole medial prefrontal cortices reflects emerging changes behaviour social cognition notably unlike frontotemporal dementia subtypes recent research demonstrated strong clinicopathological concordance tdp type common pathological subtype moreover underlying genetic cause appears relatively rare majority cases sporadic form disease relatively clear diagnosis clinical course pathological homogeneity make syndrome promising target novel disease modifying interventions development neuroimaging markers disease progression individual level important area research future studies address order assist endeavour
heterosexual individuals attention automatically captured physically attractive members opposite sex although helpful selecting new mates attention attractive relationship alternatives threaten satisfaction commitment existing romantic relationship current study tested hypothesis although mating prime would increase selective attention attractive opposite sex targets relative less attractive targets among single participants effect would reduced among people already committed long term romantic partner consistent hypotheses whereas single participants responded mating prime greater attentional adhesion physically attractive opposite sex targets relative less attractive targets participants committed romantic relationship showed effect findings extend previous research suggesting presence relationship maintenance mechanisms operate early stages social cognition
studies examine occurrence physical psychiatric health problems physical psychiatric comorbidity whether patterns differ across social groups using national comorbidity survey replication national latino asian american study current study asks patterns physical psychiatric comorbidity ppc non hispanic whites latino subgroups differentiated gender nativity ppc measurement approach reveal different patterns across groups compared physical psychiatric health problems health outcomes interest extent sociodemographic characteristics ses stress exposure social support immigration related factors explain ppc differences groups results reveal compared born non hispanic white men island born puerto rican men experience elevated ppc risk mexican latino women men experience relatively lower risk ppc relative non hispanic white counterparts social factors explain health disadvantage island born puerto rican men explain health advantage mexicans latinos elsevier inc rights reserved
direct drive wave energy converters characterized direct conversion wave energy electricity intermediate mechanical conversion system reason optimization methods maximizing absorbed power designed acting electrical generator besides type system requires power electronics connected grid paper evaluates three different current control strategies applied boost rectifier stage part optimization method system implemented simulated matlab simulink real random waves direct drive wave energy conversion unlike original application controllers input electrical power highly variable amplitude frequency controllers assessed conditions advantages disadvantages presented
support materials integrated circuits lead frame key structural components formation electrical circuits played role internal external wire connections one commonly used lead frames present copper plating layer feni alloy often found deep red color chip welding aiming phenomenon paper collected large color change point long time adopted method scanning electron microscope sem energy dispersal spectroscopy eds analysis classified discoloration point basis work conducted laboratory simulation aimed kind discoloration caused special petal shaped clusters morphology result shows alkali electroplating solution absorb carbon dioxide produce carbonate crystals coating surface crystal shows deep red color point macro process high temperature welding chip
background today patients expected take active role form self management given burden rheumatic disorder patients expected self manage order develop self management interventions fit patients needs preferences essential examine patients perspective support optimized study aimed identify support needs outpatients rheumatic disorders preferences provide self management support methods qualitative study conducted using focus groups individual interviews outpatients rheumatic disorders treated dutch university hospital interview data analysed directed content analysis coded predetermined codes derived model support needs chronically ill patients model distinguished three types support instrumental psychosocial relational support results fourteen patients participated two focus group interviews six interviewed individually patients preferred active role self management nonetheless notably needed support developing skills self managing rheumatic disorder daily life extent support needs influenced disease stage presence symptoms changes one situation trusted relationship partnership conditional receiving kind professional support patients wanted seen experienced experts living rheumatic disorder acquiring specific disease related knowledge learning deal symptoms fluctuations talking emotional aspects discussing daily life issues disease related information identified important elements self management support considered crucial support tailored individual needs expertise professionals relatives preferred support givers patients desired support fellow patients conclusion self management primarily seen patient task patients wanted seen experienced experts professionals self management support focused coaching patients developing problem solving skills practical tools training needed
human islet amyloid polypeptide hiapp major constituent islet amyloid deposits induces pancreatic cell apoptosis eventually contributes cell deficit patients type diabetes mellitus tdm study tat mediated transduction biliverdin reductase blvra investigated ins cells examine whether exogenous supplementation blvra prevented hiapp induced apoptosis dysfunction insulin secretion cells tat blvra fusion protein efficiently delivered ins cells time dose dependent manner exposure cells hiapp induced apoptotic cell death dose dependently inhibited pre treatment tat blvra transduced tat blvra reduced hiapp evoked generation reactive oxygen species crucial mediator cell destruction immunoblot analysis showed tat blvra suppressed hiapp induced increase levels proteins involved endoplasmic reticulum stress apoptosis signaling transduced tat blvra also recovered hiapp induced dysfunction basal glucose stimulated insulin secretions results suggested transduced tat blvra enhanced tolerance cells iapp induced cytotoxicity alleviating oxidative stress stress therefore tat mediated transduction blvra may provide potential tool ameliorate cell deficit pancreas tdm
humans amazingly experts processing recognizing faces however moderating factors ability present study used event related potential technique investigate influence race gaze direction visual working memory vwm face representations change detection task orthogonally manipulated race race race faces eye gaze direction direct gaze averted gaze participants required encode identities faces quantified amount information encoded vwm monitoring amplitude sustained posterior contralateral negativity spcn time locked faces notably race eye gaze direction differently modulated spcn amplitude race faces elicited reduced spcn amplitudes compared race faces displaying direct gaze hand faces displaying averted gaze independently race elicited increased spcn amplitudes compared faces displaying direct gaze interpret findings denoting race eye gaze direction affect different face processing stages
refocusing popular photographic technique widely welcomed photography cinematography currently refocusing effects movies implemented manually using professional devices computer graphics methods solutions designed videos captured common users paper propose user oriented method facilitate video refocusing daily life extra requirement stereo cameras quite popular today given stereo video one select desired focusing part single frame user selected intention tracked along timeline depth field dof based blurring effect generated scene depth estimation based stereo techniques proposed cinematographic models computational photography performance refocused videos compares favourably ones generated digital single lens reflex dslr evaluate proposed method conduct experiments several challenging stereo video datasets quantitative subjective evaluations show proposed method achieve attractive highly aesthetic performance user interactions
previous memory research exploited perceptual similarities lures targets order evoke false memories nevertheless studies attempted use lures objectively similar others study systematically controlled perceptual overlap target lure items role accounting false alarm rates neural processes underlying perceptual false memories current study looked fill gap literature using face morphing program systematically control amount perceptual overlap lures targets results converge previous studies finding pattern differences true false memories importantly expanding upon work parametric analyses showed false memory activity increases respect similarity lures targets within bilateral middle temporal gyri right medial prefrontal cortex mpfc moreover pattern activation unique false memories could accounted relatedness alone connectivity analyses find activity mpfc left middle temporal gyrus vary suggestive gist based monitoring within context false memories interestingly neither mtl fusiform face area exhibited modulation function target lure relatedness overall results provide insight processes underlying false memories enhance understanding role perceptual similarity plays supporting false memories elsevier inc rights reserved
paper interactive web based circuit simulator tool cirsim presented enhance students learning skills assist grasp basic concepts preliminary electrical engineering courses providing innovative methods interactive teaching testing project aims achieve following goals develop enhanced problem solving skills using internet portable platform education environment develop design skills sharpen critical thinking develop global comprehensive teaching circuit tools adopted nationally educational purposes students use online circuit simulator carry circuit simulation web access virtually place proposed simulator provides user friendly graphical user interface gui capability allow students conduct circuit simulation analysis provide option plot circuit responses graphically finally preliminary study done group students show effectiveness learning using proposed web based circuit solver achievement students results show great feedback students improved performance learning basic electrical engineering concepts
study aims advocate visual programming environment offering graphical items states computational problem could helpful supporting programming learning computational problem solving visual problem solving environment programming learning developed college students conducted computational problem solving activity students activities designing composing testing solutions recorded log data later analysis initially unveil students practice strategies exhibited visual problem solving environment study proposed several indicators quantitatively represent students computational practice sequence selection simple iteration nested iteration testing computational design problem decomposition abutment composition nesting composition computational performance goal attainment program size method cluster analysis empirical patterns regarding students programming learning computational problem solving identified furthermore comparisons computational design computational performance among different patterns computational practice conducted considering relations students computational practice computational design performance evidence based suggestions design supportive programming environments novice programmers discussed elsevier ltd rights reserved
medical procedures often induce physical pain psychological distress cancer patients particularly vulnerable fatigue heightened emotional distress social isolation increased risk depression severely reducing quality life potential treatment non adherence prolonged hospital stays leveraging emerging virtual reality technology prototyped serenity mobile smartphone based cancer coping intervention informed distraction therapy help alleviate symptoms coping promote patient empowerment leverages emerging low cost improve accessibility effectiveness distraction therapy describe results preliminary usability study lessons learned apply future design evaluation virtual reality interventions behavioral health
phantom cell phone experiences instances mobile cell phone users perceive ringing vibrations visual stimuli indicating incoming call message yet call message actually registers phone human signal detection issue experiences may influenced psychological factors hypothesize phantom cell phone experiences symptom psychological dependency cell phone communications resulting hypersensitivity stimuli class cell phone notification methods find support hypothesis path model analyzing responses large undergraduate sample self reported symptoms cell phone dependency strongly predicted frequency phantom cell phone experiences mediated relationships personality factors age participant sex frequency phantom cell phone experiences women younger individuals lower conscientiousness emotional stability higher neuroticism higher symptoms cell phone dependency elsevier ltd rights reserved
untreated sleep disturbances sleep disorders pose significant adverse daytime consequences place children considerable risk poor health outcomes sleep disturbances occur greater frequency children acute chronic medical conditions compared otherwise healthy peers sleep disturbances medically ill children associated sleep disorders comorbid acute chronic conditions secondary underlying disease related mechanisms treatment regimens hospitalization clinical management include multidisciplinary approach particular emphasis routine regular sleep assessments prevention daytime consequences promotion healthy sleep habits health outcomes
objective conducted randomized controlled preliminary trial examine effect dissonance based eating disorder program eating disorder symptoms cardiac risk indices community sample women subclinical clinical symptoms examining efficacy program indicated prevention treatment realms method eating disorder symptoms body mass index biomarkers cardiac risk examined dissonance assessment control conditions baseline postintervention month follow specifically assessed mean wave amplitude interval length vagal tone high frequency spectral power heart rate variability sympathetic tone low high frequency spectral power ratio via electocardiography ecg assessment period results predicted statistically significant condition control dissonance time baseline postintervention month follow interaction mixed factorial manova results results confirmed hypothesis eating disorder symptoms cardiac risk indices decreased significantly among participants dissonance condition postintervention month follow compared baseline conclusion results provide support efficacy dissonance based program reduction eating disorder symptoms cardiac risk indices among women subclinical clinical eating disorder symptoms findings establish efficaciousness dissonance based approach indicated prevention treatment realms establish efficacy reducing cardiac risk indicators
background increasingly older population improved diagnostics treatment increase number older cancer survivors thus affected cancer age symptom relief prevention functional impairment important tasks home care nursing considering patients live long time cancer disease related side effects aim study investigate extent cancer patients age reported access information counselling home care nursing services including offered cancer coordinator methods cross sectional survey used survey consisted cancer patients two regions norway living home women years questionnaire contained questions various sequences including information advices given data access use home health care services questions focused extent home health care services provided following information disease treatment information consequences complications cancer disease nutritional advice advice physical activity demographic clinical organizational variables used spss program version employed perform descriptive inferential statistics including correlation logistic regression analysis ethical reasons patients dying delirious presence cognitive impairment kind dementia excluded results results showed majority respondents reported low levels information counselling offered low levels represents study medium small small degree likert scale women years age patients gynecological hematological cancer diagnosis experienced less access information counselling respondents facing availability cancer coordinator reported significantly higher access information disease treatment nutritional advice advice physical activity compared contact home health care nurse home health care assistant conclusions results indicated availability cancer coordinator facilitated personalized information counselling older cancer patients
bipolar disorder comorbid substance abuse associated high rates treatment nonadherence adherence interventions developed date mixed effects population valued living consistency patient personal values daily actions represents potentially useful treatment target may improve adherence investigated relationship valued living medication adherence symptoms functioning sample patients diagnosed bipolar disorder comorbid substance use disorder results showed greater values action consistency explained unique amount variance change medication adherence even controlling symptom severity functional impairment reported reasons nonadherence drug use treatment beliefs also predicted nonadherence findings suggest valued living investigated potentially malleable treatment target future adherence intervention research
objective study performed assess complication diagnostic rates computed tomography guided transthoracic needle biopsy pulmonary parenchymal mediastinal lesions methods patients suspected malignancy based chest imaging could otherwise diagnosed evaluated results sixty five patients included male female average age years lesion size ranged common specific histologic subtype adenocarcinoma least common lymphoma diagnostic rate mean complication rate statistically significant associations found complication rate needle size needle path length lesion size conclusion guided needle biopsy effective diagnostic method patients mediastinal parenchymal lesions thoracotomy method also reliably differentiate benign malignant tumors
large deployment nist rbac model initiated popular research topics administration risk awareness inner threats detection etc research works context integrity verification optimization role based access control policies paper introduce synthesis problem access control policy integrity within relational databases address three vulnerabilities corrupt access control policy evolution extensions rbac model finer granularity makes management policy difficult exposure policy rdbms level illegal updates paradoxically access made authorized users decorrelation policy implemented dbms initial specification allows updating policy without ability control evolution paper defines framework organizing thinking validating compliance low level access control policies
paper analyzes advantages trends holographic projection technology characteristics large sports performance arrangement using method literature aiming providing new ideas performance arrangement thus facilitating new artistic system large sports performance modern times results show technology holographic projection gets rid tedious steps past computer programming overcomes design flaws computer graphic simulation unique degree holographic imaging presents realistic three dimensional image whose effect closer actual practice provides better idea arrangement large opening closing ceremonies well large sports performances
grounding self body experimental psychology taken body starting point science self one fundamental dimension bodily self sense body ownership refers special perceptual status one body feeling body belongs primary aim review article highlight recent advances study body ownership understanding underlying neurocognitive processes three ways first consider sense body ownership investigated elucidated context multisensory integration beyond exteroception recent studies considered exteroceptively driven sense body ownership linked side embodiment unobservable yet felt interoceptive body suggesting two sides embodiment interact provide unifying bodily self lastly multisensorial understanding self shown implications understanding social relationships especially context self boundaries taken together three research strands motivate unified model self inspired current predictive coding models
increasing limitations available energy require use new environmentally friendly resources enhancement utilization efficiency available resources energy storage systems esss promising technology realize goal however application networks requires investment must economically justified study examined effect ess use energy generation costs networks specific time period includes determining best location installation ess best possible operation schedules ess power plants achieve greatest decrease daily energy generation costs influences factors affecting final solution studied different scenarios effects power plant cost functions transmission line capacity network upgrades compared scenarios implemented ieee standard bus network best possible specifications ess reduce daily energy generation cost selected power plant cost functions found use ess network uniformed stress transmission line case would possible defer network upgrade years
recent research proposed git protein coupled receptor kinase interacting protein acts integrator aging process regulation neurometabolic integrity one commonly accepted hallmarks aging process thymic involution relatively young age months old git mice present prematurely distorted thymic structure dysfunction compared age matched month old wild type control cbl mice disruption thymic structure git gitko mice associated significant reduction expression cortical thymic marker troma cytokeratin double positive single positive cells also markedly reduced month old gitko mice compared age matched control wild type mice coincident premature thymic disruption gitko mice unique generation novel cervical organ parathymic lobes novel organs exhibit classical peripheral lymph node like characteristics expressed high levels cell progenitors reflexively reduced gitko thymi using signaling pathway analysis gitko thymus parathymic lobe transcriptomic data found molecular signaling functions lost dysfunctional gitko thymus selectively reinstated novel parathymic lobe suggestive compensatory effect premature thymic disruption broader inspection high dimensionality transcriptomic data gitko lymph nodes spleen thymus parathymic lobes revealed systemic alteration multiple proteins dbp tef per per fbxl ddit sina involved multidimensional control cell cycle clock regulation cell senescence cellular metabolism dna damage altered cell clock regulation across immune nonimmune tissues therefore may responsible premature aging phenotype gitko mice
objectives aim evaluate association perioperative inflammatory biomarkers atrial fibrillation cardiac surgical patients methods forty two patients undergoing cardiac surgery divided three groups according occurrence group patients group patients new onset postoperatively group patients preoperative history atrial fibrillation serum levels ptx crp tlr sfas mmp mmp measured following time points surgery immediately surgery postoperative days pod results serum levels ptx showed significant difference groups pod pod levels different groups immediately surgery hours surgery pod difference groups pod levels sfas levels differed groups pod pod also difference pod groups significant differences groups seen biomarkers conclusion study demonstrates significantly different dynamics ptx sfas levels cardiac surgery relation
entity resolution concerns identifying pairs entities refer underlying entity avoid pairwise comparison entities blocking methods used sorted neighborhood established blocking method relational databases applied schema free resource description framework rdf data sources widely prevalent linked data ecosystem paper presents sorted neighborhood workflow may applied schema free rdf data workflow modular makes minimal assumptions inputs empirical evaluations proposed algorithm five real world benchmarks demonstrate utility compared two state art blocking baselines
paper single operational transresistance amplifier otra based biquadratic filter configuration proposed topology used synthesize lowpass highpass bandpass filter functions appropriate admittance choices configuration implement filters high quality factor controlled independent angular frequency workability proposed biquad configuration demonstrated pspice simulations using cmos process parameters provided mosis agilent
objectivewe studied whether increased emergency contraception availability women age associated higher probability risky sexual practices dataa total individual year observations women aged older extracted national longitudinal survey youth october november study designwe modeled three binary outcome variables sexual activity sexual activity one partner sex without condom women multiple partners women states state level policy changes prior fda ruling women states subject national policy change jointly separately findingswe found different results estimating state federal changes separately national change associated reduction probability sexual activity reduction likelihood reporting multiple partnerships relationship national policy change unprotected sexual activity relationship probability sexual activity multiple partnerships women states policy changes find women states likely report unprotected sex
backgroundin general rain fed agriculture practised many areas western sudan therefore imperative adopt appropriate rainwater harvesting reuse technique promoting soil water management research sustain crop productivity sorghum sorghum bicolor primary stable crop sudan extensive field experiments conducted study effect water harvesting techniques whts supplemental irrigation infiltration rate soil moisture content smc growth productivity sorghum two rainy seasons resultsthe results showed whts affected soil physical properties growth productivity parameters sorghum results indicated tied ridging trwsi produced highest values accumulative smc sorghum productivity kgh season respectively whereas season values kgh accumulative smc sorghum productivity respectively basin bwsi ranked second next trwsi seasons conclusionhence water harvesting expected play significant role terms sustainable agricultural socio economic development western sudan similar areas society chemical industry
aims aim study evaluate safety efficacy left atrial appendage occlusion laao amplatzer cardiac plug acp amulet using aspirin alone asa post implantation antithrombotic treatment methods results single centre prospective non randomised study laao acp amulet consecutive cohort treated asa alone post implantation primary outcome device related thrombosis secondary outcomes ischaemic stroke major bleeding clinical follow conducted six weeks months tee cardiac one hundred seven patients included analysis three patients excluded due mechanical valve prosthesis cha vasc score bled successful implantation obtained patients periprocedural complication rate median follow years total patient years device related thrombosis detected cases stroke occurred patients annualised rate risk reduction compared predicted rate annual risk major bleeding reduced conclusions laao acp amulet safely performed asa monotherapy implantation without increased risk device related thrombosis stroke
background depression common low income pregnant women treatments need fitted meet needs conducted randomized controlled trial comparing brief interpersonal psychotherapy briefipt enhanced treatment usual etau perinatal depression low income women brief ipt model designed better engage low income women utilizing engagement session providing flexible delivery sessions pragmatic case management methods pregnant women aged weeks gestation recruited urban prenatal clinic women scoring edinburgh depression scale meeting depressive disorder criteria randomized either brief ipt etau assessed treatment outcomes acceptability feasibility intervention measured session attendance results depression scores significantly decreased brief ipt etau brief ipt participants reported significant improvements social support satisfaction compared etau participants even controlling concurrent depressive symptoms brief ipt participants reported high satisfaction program however many participants participate full session course treatment average sessions attended range limitations small sample size use self report measures lack active psychotherapy control group limits interpretation study results conclusions brief ipt perinatal depression acceptable low income women helpful improving depressive symptoms social support however feasibility treatment limited relatively low session attendance spite efforts maximize treatment engagement additional modifications meet needs low income women discussed
conclusively predicting quality software system software testing plays important vital role finding faults early observe failures anomalies implementation stage software testing done bugs defects detected software passed maintenance phase success failure software project often attributed development methodology used also observed many scenarios software engineering methods implemented true spirit moreover many development methodologies cater change well follow predefined development path allows less deviation software testing regression testing important type software testing change made software regression testing done check influence parts software regression testing test cases prioritized order reuse new test cases existing test cases test case prioritization done using different techniques paper presents review different test case prioritization techniques
direct recognition porcine major histocompatibility complex mhc proteins human cells well documented eliminating donor porcine mhc proteins may therefore beneficial pig human xenotransplants end attempted exploit viral stealth mechanisms eliminate pig mhc class cell surface expression pig kidney cells stably transfected herpes simplex virus hsv icp gene icp cells exhibited dramatic reduction mhc class cell surface expression compared untransfected cells test effect regulation porcine mhc class human cellular immune responses human enriched cell line anti cells reactivity towards cells derived repeated stimulation human cells cells stably transfected costimulatory molecule cells anti cells efficiently lyzed cells icp class negative cells consistent effector function anti cells showed robust proliferative response cells proliferate cells also expressed hsv icp results suggest virus stealth technology exploited xenotransplantation
paper presents robust diagnosis technique iteratively analyzing pattern multiple fault signatures motor current signal mathematically experimentally proved proposed diagnosis algorithm provides highly accurate monitoring performance minimizing false detection miss detection rate high noise nonlinear machine operating condition results verified digital signal processor based motor drive system motor control fault diagnosis performed real time
present scalable algorithms level set method dynamic adaptive quadtree octree cartesian grids algorithms fully parallelized implemented using mpi standard open source pest library solve level set equation semi lagrangian method similar serial implementation free time step restrictions achieved introducing scalable global interpolation scheme adaptive tree based grids moreover present simple parallel reinitialization scheme using pseudo time transient formulation parallel algorithms scale stampede supercomputer currently using cpu cores limit current account finally relevant application algorithms presented modeling crystallization phenomenon solving stefan problem illustrating level detail would impossible achieve without parallel adaptive strategy believe algorithms presented article interest useful researchers working level set framework modeling multi scale physics general elsevier inc rights reserved
objective main objective determine prediction level alexithymia difficulties emotion regulation pathological gambling secondly study aimed examine mediating role difficulties emotion regulation relationship alexithymia pathological gambling method sample consisted male gamblers average age standard deviation addition sociodemographic form south oaks gambling screen sogs toronto alexithymia scale tas difficulties emotion regulation scale ders used collect data results regression analyses revealed amount money bet total score tas ders significantly predicted pathological gambling addition difficulties emotion regulation partial mediator role relationship alexithymia pathological gambling conclusion argued individuals high alexithymia become prone addiction behavior emotion dysregulation addition alexithymia level difficulties emotion regulation seen play important role pathological gambling context study contributes relevant literature discussing alexithymia emotion regulation pathological gambling together
recent evidence suggests involvement toxoplasma gondii infection emergence psychotic affective disorders report describe case young brazilian woman affected recurrent ocular toxoplasmosis presenting manic episode psychotic features context diagnosis bipolar disorder type observed relationship ocular manifestations clinical course bipolar illness confirmed molecular analyses nested pcr well high level gondii specific igg case report first showing presence circulating parasite dna time occurrence psychiatric symptoms thus providing support possible role parasite pathogenesis cases
many conventional truck working machines equipped additional hydraulic tooling manipulation systems usually fed mechanical connection internal combustion engine involving poor efficiency particular common situation industrial vehicles whose mission profiles involves relevant consumption energy board hydraulic systems respect one really needed traction purpose work proposed innovative solution based adoption system aimed recover braking energy order feed efficient board hydraulic actuation system proposed system adopted real application isuzu truck equipped hydraulic tooling garbage collection prototype system designed assembled tested showing relevant improvement system efficiency feasibility proposed approach paper proposed solution presented showing simulation models preliminary validation results including experimental devices assembled perform tests elsevier ltd rights reserved
background research consistently found favourable exchange one proximal social environment positive effects mental health wellbeing adults physical disabilities may fewer opportunities favourable exchange therefore effects mental health wellbeing may less advantageous aim study systematically review quantitative studies exploring associations social relationships mental health wellbeing persons physical disabilities methods databases pubmed psycinfo scopus searched relevant studies published data extracted study participants characteristics independent dependent variables used measures effects sizes associations social relationships mental health wellbeing narrative review performed synthesize findings along constructs social support social networks negative social interactions family functioning relationship quality results included studies cross sectional longitudinal studies included measure social support concepts less often studied social networks negative social interaction family functioning relationship quality half studies included depression outcome followed wellbeing composite mental health measures anxiety psychological distress posttraumatic stress disorder hopelessness although trends associations social support mental health wellbeing consistent around quarter studies failed report significant associations social networks related depression mental health wellbeing measures family functioning negative social interactions relationship quality showed consistent associations mental health wellbeing however studies available conclusions review indicates social relationships play important role mental health wellbeing persons disabilities although findings less consistent general populations strength associations vary constructs integrating persons disabilities social networks seems sufficient rehabilitation professionals together affected persons peers ensure high quality relationships tailored support available
background improve patient outcomes center medicare medicaid services cms implemented core measures outline initial treatment septic patient measures include initial blood culture collection prior antibiotics adequate intravenous fluid resuscitation early administration broad spectrum antibiotics sought determine paramedics initiate cms sepsis core measure bundle prehospital field reliably methods retrospective case series service ems system model greenville south carolina november february adult prehospital sepsis assessment tool created using surviving sepsis guidelines signs systemic inflammatory response heart rate respiratory rate oral temperature known suspected source infection sepsis alert called paramedics upon access set blood cultures blood lactate analysis collected prior field antibiotic administration sepsis alert compared serum lactate levels icd admitting diagnosis sepsis severe sepsis septic shock blood culture contamination serum lactate antibiotic match determined hospital laboratory analysis results total trained paramedics called sepsis alerts patients male mean age patients missing discharge diagnosis eliminated admitting diagnosis sepsis overall sepsis severe sepsis septic shock total blood cultures collected prehospital setting contamination rate contamination found total uncontaminated blood cultures found positive growth growth ems administered antibiotics matched blood culture positive growth patients lactate level greater patients adverse effects reported prehospital administration antibiotics conclusion study demonstrates successful implementation ems driven cms sepsis core measure bundle prehospital setting paramedics acquire uncontaminated blood cultures safely administer antibiotics prior hospital arrival among patients recognized sepsis alerts
although perceived inconsistencies play central role people understand world research impression formation largely neglected lay perceptions inconsistency current research seeks address gap investigating perceived inconsistencies positive negative information along dimensions warmth competence using memory based measure surprise three studies found expectancy violation effect behaviors incongruent valence prior information effect generalized across warmth competence indicating prior information along one dimension led valence congruent expectations along dimension evidence valence asymmetries expectancy violations regardless whether impression dimension involved warmth competence fourth study replicated findings using self report measure perceived inconsistency implications research person perception attitudes cognitive consistency discussed elsevier inc rights reserved
operational amplifier important portion various analog mixed signal circuits today use mixed mode integrated circuits rises analog circuits particularly operational amplifiers cmos technology difficult design due challenging time consuming tasks like counting various conflicting benchmarks wide variety design factors paper presents use particle swarm optimization pso algorithm optimum plan two stage cmos operational amplifier circuit pso algorithm used accept required functionalities performance specifications considering ideal sizing two stage amp circuit optimization code pso algorithm integrated ngspice circuit simulator circuit simulated using bsimv mosfet models tsmc cmos processes technology complete optimization system test setup run ubuntu operating system results obtained pso algorithm compared earlier works
network traffic classification process analyzing traffic flows associating different categories network applications network traffic classification represents essential task whole chain network security important widely spread applications traffic classification ability classify encrypted traffic identification malicious traffic flows enforcement security policies use different applications passively monitoring network utilizing low cost low complexity wireless local area network wlan devices desirable mobile devices used existing office desktops temporarily utilized computational load low reduces burden existing network hardware aim paper investigate traffic classification techniques wireless communications aid intrusion detection key goal passively monitor classify different traffic types wlan ensure network security policies adhered classification encrypted wlan data poses unique challenges normally encountered wired traffic wlan traffic analyzed features used input six different machine learning algorithms traffic classification one algorithms gaussian mixture model incorporating universal background model applied wired wireless network classification authors also propose algorithm makes use well known vector quantization algorithm conjunction decision tree referred tree adaptive parallel vector quantiser algorithm number advantages algorithms tested suited wireless traffic classification average score harmonic mean precision recall achieved training testing day across six distinct traffic types
mineralocorticoid receptor highly expressed hippocampus prefrontal cortex involved social cognition recently found pharmacological stimulation enhances emotional empathy affect cognitive empathy current study examined whether blockade impairs empathy patients major depressive disorder mdd healthy individuals placebo controlled study randomized patients mdd without psychotropic medication healthy individuals either placebo spironolactone antagonist subsequently participants underwent two tests social cognition multifaceted empathy test met movie assessment social cognition masc measuring cognitive emotional facets empathy met found significant main effect treatment main effect group cognitive empathy highly significant treatment group interaction patients higher cognitive empathy scores compared controls placebo condition spironolactone furthermore spironolactone condition reduced cognitive empathy seen mdd patients controls emotional empathy affected blockade masc effect spironolactone could revealed depressed patients appear exhibit greater cognitive empathy compared healthy individuals blockade reduced cognitive empathy mdd patients level healthy individuals future studies clarify impact functioning different domains social cognition psychiatric patients
paper discuss structure preserving iterative solutions large scale sparse projected periodic discrete time algebraic lyapunov equations arise periodic state feedback control problems model reduction periodic descriptor systems extend idea computing generalized inverses periodic discrete time descriptor systems using left right deflating projectors associated eigenstructures periodic singular matrix pairs computed periodic inverses used smith iterative method compute iterative solutions projected periodic discrete time algebraic lyapunov equations low rank version method also presented used compute low rank approximations solutions projected periodic discrete time algebraic lyapunov equations moreover consider application lyapunov solvers balanced truncation model reduction periodic discrete time descriptor systems numerical results given illustrate efficiency accuracy proposed methods
targeting tumor necrosis factor signalling antibodies led revolution treatment psoriasis locally inhibiting tumor necrosis factor alpha converting enzyme tace adam could potentially mimic effects help treat mild moderate psoriasis without reported side effect systemic tace inhibitors efforts identify new tace inhibitors presented enzymatic sar well adme physico chemistry data presented study culminated identification potent enzymatic inhibitors suboptimal cellular activity series discussed context previously published results elsevier ltd rights reserved
blending effect design pattern five surface plane developed drawing important design pattern blending three dimensional pattern design realize automation pattern design target pattern design air brushing based square design picture therefore effect bad especially edges surfaces edge processing method developed solve problem pixels compressed accordance image pixel compression method according processing steps computer programming performed results shows floral drawing blending design figure extend adjacent surfaces naturally blending effect great three dimensional blending perform
people anorexia nervosa display reduced facial expression emotions study investigated expression positive affect response film examining duchenne non duchenne smiles women recovered rec acute healthy controls results indicated rec group exhibited duchenne non duchenne smiles higher duration intensity group comparable group findings warrant longitudinal studies confirm reduced expressivity linked acute ameliorating recovery elsevier ireland ltd rights reserved
current study investigated relationship maladaptive five factor model ffm personality traits anxiety sensitivity cognitive concerns suicide ideation sample undergraduate students selected based scores screening questionnaire regarding borderline personality disorder bpd symptoms endorsed elevated bpd symptoms pre screen analyses completed beginning semester oversampled comparison low moderate symptoms indirect effect mediation results indicated maladaptive personality traits anxious uncertainty dysregulated anger self disturbance behavioral dysregulation dissociative tendencies distrust manipulativeness oppositional rashness indirect effects suicide ideation anxiety sensitivity cognitive concerns personality traits correlated suicide ideation well maladaptive personality traits despondence affective dysregulation fragility positive correlates suicide ideation predicted suicide ideation traits entered one linear regression model indirectly related anxiety sensitivity cognitive concerns implication targeting anxiety sensitivity cognitive concerns evidence based practices reducing suicide risk bpd discussed
tnf inhibitors used psoriasis pso psoriatic arthritis psa associated increased risk cardiac cerebrovascular events however whether tnf inhibitors reduce cardiovascular event still unclear therefore aimed evaluate effect tnf inhibitors adverse cardiovascular events cves pso without psa undertook meta analysis clinical trials identified systematic searches medline embase wanfang database cochrane database google scholar december five studies patients included overall compared topical photo treatment tnf inhibitors associated significant lower risk cve additionally compared methotrexate mtx treatment risk cve also markedly decreased tnf inhibitor group meanwhile tnf inhibitors linked reduced incidence myocardial infarction compared topical photo mtx treatment respectively furthermore trend decreased rate mortality tnf inhibitor group compared therapy tnf inhibitors appear net clinical benefits regard adverse cardiovascular events pso psa rigorous randomized controlled trials need evaluate whether tnf inhibitors truly result reduction cardiovascular diseases
paper provides results empirical study professional motivation level emotional burnout among flight crew members vladivostok international airport study involved civil aviation pilots aged years years work experience zamfir motivation professional activity technique rean modification questionnaire assessing motivational potential used studying professional motivation level emotional burnout measured using maslach burnout inventory mbi vodop yanova modification boyko diagnostics level emotional burnout technique ilyin modification study findings suggest civil aviation pilots interested process professional activities tried part staff build friendly relationship colleagues prevailing intrinsic professional motivation study showed pilots average level emotional burnout moreover data revealed stress fatigue decrease professional effectiveness cognitive decline avoidance defense mechanism refusing problem solving third respondents high level emotional burnout respondents noted physical emotional fatigue exhaustion personal resources feelings hopelessness helplessness somatic disorders loss appetite headaches disturbances sleep wakefulness fifth pilots low level emotional burnout finding suggests respondents well adjusted professional activities selfcritical frank besides increasing rates emotional burnout change orientation motivation intrinsic extrinsic
controller design transverse flux machines substantial challenge due nonlinear dynamic behavior paper places particular emphasis phase current control loop since directly affects generated torque state space representation phase current harmonics transverse flux machines introduced expand applicable control structures speed dependent feedforward controller combined harmonic tracking controller achieve accuracy fast dynamic response
critical issues scientific reproducibility raised biomedical research including reliability data analyses within given study case example article examined reproducibility issue pertaining use administrative data systems evaluation child maltreatment prevention making use prevention study conducted decade ago provided unique opportunity place randomization study randomized counties condition found community wide implementation parenting family support intervention produced positive impact county wide rates substantiated cases home placements documented state information system key consideration whether extent administrative record data examined retroactively decade later original study time period would yield comparable results based data acquired time study results indicated despite small changes time data patterns statistical effects reproducible two archival outcome variables substantiated reproduced analyses reflected higher effect sizes clear pattern reduction function intervention home placements effect sizes quite comparable original ones reflecting preventive impact overall case study illustrated verifiability data reproducibility context population outcome evaluation underscores importance reliable population prevalence measurement essential part comprehensive public health strategy aimed prevention elsevier ltd rights reserved
present study undertaken elucidate effect alpha linolenic acid ala omega gamma linolenic acid gla omega experimental autism features induced early prenatal exposure valproic acid vpa albino wistar pups pups scrutinized accounts behavioral biochemical inflammatory markers results suggested gla impart significant protection comparison ala vpa induced autism features scrutinized histopathologically cerebellum gla treated animals evident marked protection toward neuronal degeneration neuronal loss comparison ala concomitant administration ala gla vpa demonstrated marked cutdown pgp expression gla pronounced effect henceforth concluded ala gla impart favorable protection vpa induced autism like features gla pronounced effect
atmospheric effects influence signal registered remote sensors might minimized order provide reliable spectral information aquatic systems application atmospheric correction aims minimize effects avoid overestimation remote sensing reflectance accurately provides better information state aquatic system means establishing concentration aquatic compounds precisely aim study evaluate outputs several atmospheric correction methods dark object subtraction dos quick atmospheric correction quac fast line sight atmospheric analysis hypercubes flaash atmospheric correction oli lite acolite provisional landsat surface reflectance algorithm lsr order investigate suitability estimating total suspended matter concentrations tsm barra bonita hydroelectrical reservoir establish tsm concentrations via atmospherically corrected operational land imager oli scene tsm retrieval model calibrated validated situ data thereby achieved results tsm retrieval model application demonstrated lsr able provide suitable values green red spectral bands consequently lowest tsm retrieval errors mean absolute percentage error respectively retrieved near infrared band still challenge tested algorithms cospar published elsevier ltd rights reserved
application auto guided tractor rice cultivation korean paddy fields may limited tire slippage headland turning due wet soil conditions use small sized fields thereby requiring accurate estimation sliding parameters elsevier rights reserved
traditional heterosexual dating courtship scripts men pay date women take partner last name marriage reflect different standards desirable behavior women men analogous sexual double standards dating double standards reflect greater agency power traditionally accorded men society present study investigated factors related young heterosexual adults endorsement dating double standards participants female male undergraduates california public university female ages years old diverse ethnic backgrounds heterosexual dating double standards scale respondents rate desirability five dating courtship behaviors initiate date hold door open pay date propose marriage take spouse last name separately women men preliminary analyses revealed participants generally expressed double standards rating desirability behaviors differently female male characters traditional direction paying date rated desirable man woman predicted dating double standards would positively related factors previously found predict traditional gender roles viewing popular media religious attendance well attitudes reflect traditional views conservative political beliefs benevolent hostile sexism disavowing feminist identity hypotheses generally supported among correlations dating double standards strongly associated benevolent sexism among women men hostile sexism among men implications future research discussed
one promising strategies recommended increasing energy security mitigating transportation sector emissions support alternative fuel technologies including electric vehicles however considerable amount uncertainty regarding market penetration electric vehicles must accounted order achieve current market share goals paper aims address inherent uncertainties identify possible market share electric vehicles united states year using developed electric vehicle regional market penetration tool first considering respective inherent uncertainties vehicle attributes evaluated different vehicle types including internal combustion engine gasoline hybrid three different electric vehicle types addition agent based model developed identify market shares studied vehicles finally market share uncertainties modeled using exploratory modeling analysis approach government subsidies play vital role market adoption electric vehicle combined word mouth effect may achieve electric vehicle market share new sales average electric vehicles highest market share among electric vehicle options elsevier ltd rights reserved
men women exhibit differences development progression alzheimer disease factors underlying sex differences well understood review emphasizes contributions sex steroid hormones relationship sex women events decrease lifetime exposure estrogens generally associated increased risk whereas estrogen based hormone therapy administered near time menopause may reduce risk men estrogens exhibit age related reduction significantly associated risk rather normal age related depletions testosterone plasma brain predict enhanced vulnerability estrogens androgens exert numerous protective actions adult brain increase neural functioning resilience well specifically attenuating multiple aspects related neuropathology aging diminishes activational effects sex hormones sex specific manners hypothesized contribute relationship aging sex steroid hormones may also drive sex differences organizational effects developmental sexual differentiation brain specifically sex hormone actions early development may confer inherent vulnerability female brain development advanced age combined effects organizational activational effects sex steroids yield distinct sex differences pathogenesis significant variable must rigorously considered future research wiley periodicals inc
yet another effort produce better permanent magnet less rotor winding less brushless electric motor drives paper reports work related multiphase high saliency rotor dual flat top alternative current control brushless bldc reluctance machine drives aim produce high torque density low loss torque less rotor windingless machine full usage machine windings core inverter kva new derivation principle operation essential rotary linear machine topologies finite element method fem analysis torque density torque pulsations already built phase poles lab prototype made available show promising results experimental flux decay test results presented together standstill torque measurements validate finite element model advanced iron loss computation finite element analysis indicates moderate core loss although high air gap magnetic flux density current harmonics occur natural behavior bldc machine electrical mechanical parameter identification followed development circuit model based fem imported data parameters four quadrant control strategy proposal running experiments motoring generating speed reversal field weakening modes using dspace platform drives three three phase inverters power star connected six phase bldc multiphase reluctance machine presented thus showing operation reduced number switches inverter
introduction hereditary angioedema hae usually results inhibitor inh deficiency dysfunction rare autosomal dominant disorder characterized localized non pitting edema skin submucosal tissues upper respiratory gastrointestinal tracts without significant wheals pruritus due temporary increase vascular permeability forms hae described therapies approved hae inh deficiency hence review focuses inh hae areas covered aim review article present current available therapies treatment acute attacks well short long term prophylaxis hereditary angioedema due inhibitor deficiency inh hae authors highlight also critical issues management inh hae continuously evolving thanks evidence clinical trials post marketing experience ongoing studies expert opinion last decade quality life inh hae patients significantly improved due increased knowledge awareness disease improved patient support major progress pharmacotherapy ongoing research probably provide patients new effective therapeutic agents near future
aims objectives study conducted investigate model social support care people living hiv aids plha explore role people living aids quality life qol reference improving nursing policies aids background social support care important factors impacting qol people living hiv aids studies conducted upon influence social support qol people living hiv aids mainly based cross sectional design design study nonrandomised controlled community intervention study methods participants diagnosed people living hiv aids beijing hospital received comprehensive social support care december december evaluate impact social support care model people living hiv aids study analysed different dimension scores social support scale quality life intervention correlation net benefit value social support qol various dimensions analysed results significant differences score objective support usage support social support net values objective support score usage support respectively intervention significant differences physiological function role physical general health vitality social function mental health health transition total score quality life canonical correlation analysis net values social support qol indicated first second canonical correlation statistically significant correlation coefficients conclusion social support care intervention model effectively improve perceived subjective feeling social support qol condition people living hiv aids strategies improve social support care intervention programmes strongly encouraged relevance clinical practice method simple cost effective could way improve quality life condition people living hiv aids
paper focuses new kind artificial neural networks transform artificial neural networks ztanns proposed use transform instead ordinary weights linear activation function artificial neuron extension allows use artificial neural networks new areas ordinary description artificial neural networks special case description proposed paper also contains description use ztann automatic identification objects digital control system elsevier rights reserved
scaling laws used size certain machine design known performance needs adjusted new application known requirements machine design geometrically scaled one needs determine performance scaling laws derived study allow one quickly accurately recalculate parameters geometrically scaled permanent magnet machine basically consist two separate important scaling procedures axial scaling radial scaling third inevitable scaling procedure rewinding used adjust winding required voltage level exact simple analytical equations various parameters torque power losses mass resistance inductance efficiency etc machine derived using three independent scaling factors one scaling procedure special attention given inclusion end winding influence three dimensional permanent magnet loss effects algorithms fast determination winding parameters given voltage fast determination scaling factors scaling based torque requirement stack length limitation presented derived scaling equations numerically validated using two state art motor design software packages automated extraction parameters based finite element calculations
quantifying contributions climate change human activities ecosystem evapotranspiration gross primary productivity gpp changes important adaptation assessment sustainable development spatiotemporal patterns gpp estimated north china plain ncp physical remote sensing based model contributions climate change human activities gpp trends separated quantified first difference trending method multivariate regression results showed annual gpp increased weakly climate change human activities contributing trend gpp trend respectively cropland increasing trends mainly occurred wheat growing stage contributions climate change wheat maize negative precipitation sunshine duration major climatic factors regulating gpp trends concluded human activities main drivers long term tendencies water consumption gross primary productivity ncp
purposes study report systematic approach validating spanish version principal instructional management rating scale apply scale cross national comparison principal instructional leadership study yielded validated spanish language version pimrs teacher form offers model scale validation scholars interested preparing instrument use outside culture origin researchers used back translation expert panel procedure combined psychometric analysis order achieve cultural equivalency translation psychometric properties reliability theory test reliability validity cfa rasch analysis new version assessed compared original version order underpin validity validation study employed sample teachers principals santiago chile study yielded comprehensive analytical approach cultural adaptation survey instruments well scale used spanish speaking contexts study demonstrated variability patterns instructional leadership practice across several national contexts
new styles ways life lead greater use wireless networks mobile device tool data transmission susceptible threats transmission channels network security plays important role guaranteeing availability privacy integrity information one techniques helps task cryptography whose foundation transform message unintelligible except key decipher research focuses use rsa algorithm mobile devices encrypted data sent communication channels called threads formulas processes executed server help execute encryption decryption data carry prototype exchange data mobile devices wirelessly designed implemented conducting performance tests three nodes improve security results show efficiency algorithm additionally functionality times encryption decryption fast sending information without method algorithm used
background although latinos living united states disproportionately affected hiv development implementation evaluation hiv prevention testing linkage care interventions lag behind efforts occurring communities address sociocultural barriers testing developed multilevel intervention study pilot evaluation individual level component intervention animated video modules address specific barriers hiv testing common among foreign born latino men methods conducted survey assessing hiv risk barriers testing convenience sample foreign born latino men baltimore tested hiv within past year intention test next months measured viewing intervention module selected based survey responses results fifty two participants never tested hiv participants previously tested hiv mean time since last test years participants intention test hiv significantly increased watching module increased intention test associated socio demographic characteristics age country origin reported sexual behaviors number sex partners past year discussion results suggest culturally sensitive individually tailored intervention additional tool encourage hiv testing among previously untested foreign born latino men one demographic groups highest risk delayed hiv diagnosis united states
wilmington senior center developed year multidisciplinary health wellness initiative entitled time life promote healthy aging participants attending countywide senior centers purpose paper describe development implementation evaluation methodology outcomes senior health wellness project consisted programs total long term programming present several challenges implementation evaluation assessing outcomes critical documenting program value accountability participant completed surveys post series focus groups utilized evaluation tools findings indicate program objectives increasing knowledge motivating adoption maintenance healthy lifestyle met varying degrees third objective assessing usefulness resources inform health related decisions unable evaluated due cross sectional nature data collection post series focus groups indicated topics interest seniors money management medications staying mentally physically fit evaluations showed long term programming challenging successful sustainable format senior health education
traditional hyperelastic models materials allow unlimited increase strain energy strain increase clear however real material accumulate energy unlimitedly sustaining large enough strains present work introduce limiter strain energy critical failure energy interpreted failure constant characterizing material toughness show critical failure energy controls materials softening softening enrich existing model intact material failure description demonstrate efficiency softening hyperelasticity approach variety analytically tractable boundary value problems variety material models proposed softening hyperelasticity approach possible alternative simplistic pointwise failure criteria strength materials one hand sophisticated approach damage mechanics involving internal variables hand elsevier ltd rights reserved
following paper novel method color image encryption proposed based high level chaotic maps introduced two novel chaotic maps cosinus arcsinus sinus power logistic spl better chaotic behaviour available chaotic maps scheme like image encryption schemes two main phases pixel shuffling pixel diffusion made efficient chaotic permutation method extremely dependent plain image proposed method compared availabale permutation methods pixel shuffling stage better performance lower computational overhead another advantage permutation method less correlation adjacent pixels permuted image causes high confusion levels lower iterations pixel diffusion phase introduced coupled map based spl map change color component distinctly moreover used map generate three chaotic sequences deriving initial seeds coupled map random manner followed three chaotic matrix created change pixels color component values proposed diffusion phase implies desirable uniformly distributation color histogram encrypted image makes scheme robust statistical attacks addition creating secret keys large size high sensitivity original pictures leads acceptable results average npcr uaci resistance brute force attack experimental results reveal new image encryption scheme charectristics secure encryption algorithm large key space high security high sensitivity
rotary kilns long history use classical industries able achieve high temperatures higher thermal efficiencies reactor types performance widely studied classified according different parameters since well known technology rotary kilns selected high temperature solar processes article initially presents brief review rotary kiln technology focuses employment devices thermal thermochemical processes conducted concentrating solar energy among solar devices novel rotary kiln prototype thermochemical processes presented compared static solar reactor finally practical conclusions design operation solar rotary kilns remarked analysis main limitations presented elsevier ltd rights reserved
introduction diabetic men erectile dysfunction widely studied low testosterone levels causing low sex drive erectile dysfunction aim assess erectile dysfunction sex drive relation testosterone serum levels type diabetes mellitus patients materials methods total patients type enrolled cross sectional study according treatment types divided three groups group patients treated metformin group patients treated sulfonylurea group healthy normal non diabetic men taken control total testosterone free testosterone free androgenic index fai sex hormone binding globulin shbg lipid profile anthropometric parameters metformin sulfonylurea treated patients compared normal healthy men along sexual health inventory men shim results total testosterone serum levels high sulfonylurea treated patients compared metformin treated patients similarly shbg levels significantly higher sulfonylurea treated patients compared metformin treated patients also significantly higher sulfonylurea treated patients compared metformin treated patients significantly low compared control fai also significantly higher sulfonylurea treated patients compared metformin treated patients hand bioavailable testosterone low metformin treated patients nmol compared control shim low metformin treated patients significantly differed control sulfonylurea treated patients intergroup differences significant conclusion metformin leads significant reduction testosterone levels sex drive induction low testosterone induced erectile dysfunction whereas sulfonylurea leads significant elevation testosterone levels sex drive erectile function
background injury greatly impact patients long term quality life resilience refers individual ability positively adapt facing stress trauma objective study examine relationship preinjury resiliency scores quality life injury methods two hundred twenty five adults admitted injury severity score greater without neurologic injury included item short form administered time admission repeated month months months months injury connor davidson resilience scale completed admission scores categorized high resiliency high resiliency group based trajectory modeling used identify distinct recovery trajectories physical component scores pcs mental component scores mcs item short form multinomial logistic regression used determine whether baseline resiliency scores predictive pcs mcs recovery trajectories results age race sex mechanism injury charlson comorbidity index injury severity score presence hypotension admission insurance status associated high resiliency compared made less per year made per year higher odds high resilience group odds ratio confidence interval three pcs mcs trajectories identified relationship resilience pcs trajectory however patients high resiliency scores less likely belong trajectory trajectory lowest mental health scores course study follow study month month month month conclusion patient resiliency predicts quality life injury regards mental health patients suffering poor mental health outcome trajectories efforts teach resiliency skills injured patients could improve long term mental health injured patients trauma centers well positioned carry interventions level evidence prognostic epidemiologic study level iii
given many developing economies depend primary commodities fluctuations commodity prices may imply significant effects wellbeing children investigate paper examines relationship child mortality commodity price movements reflected country specific commodity terms trade employing panel low lower middle income countries period show commodity terms trade volatility increases child mortality highly commodity dependent importers suggesting type scarce resource curse strikingly however good institutions appear able mitigate negative impact volatility paper concludes highlighting tripartite relationship child mortality volatility good institutions posits effective approach improving child wellbeing low lower middle income countries combine hedging import diversification improvement institutional quality published elsevier ltd
importance software architecture design acknowledged important factor high quality software development different efforts industry academia produced multiple system development methodologies sdms include design activities addition standardization bodies defined different recommendations regarding software architecture design however industry software architecture best practices currently poorly employed fact constrains benefits industry potentially obtain software architecture design software development paper analyze degree four main recognized sdms rup rational unified process msf microsoft solutions framework mbase model based system architecting software engineering rup soa rational unified process service oriented architecture adhere best practices software architecture design analysis points important strengths weaknesses regarding software architecture design highlights relevant issues software architecture design need incorporated methodologies elsevier rights reserved
ubiquitous computing technology effectively utilized shared environments groups people close proximity shared environments pervasive real world hence way managing environments impact quality life also business competitiveness however making decisions intelligent shared environment never straightforward intelligence needs capable choosing parameters satisfy inhabitants different preferences heterogeneous influences decision till today thorough research scientifically investigate type decision making problems though many systems already deployed research proposes methodology making decisions circumstances current future works addressed paper also conductive human centric networks service systems since issues addressed also essential constitutes human centric networks elsevier inc rights reserved
bluetooth low energy emitters used beacons gained lot traction last years technology continuously improving possible consumers buy highly durable beacons reasonable price main use beacons harnessed context aware software applications requiring localization benefit beacon technology however reliability accuracy location information rather crucial used ambient intelligence healthcare domain systems currently rely received signal strength indication rssi may highly reliable highly susceptible diffraction multipath propagation angle arrival lack line sight absorption human body paper propose investigate use two features addition mean rssi new algorithm presented paper improve localization accuracy simple proximity localization
studies implications population density energy consumption small medium sized cities low middle income countries limited paper estimates analyses energy consumption using diverse set methods compare two medium sized cities thailand similar urban forms socioeconomic characteristics different population densities namely less dense city chaiyaphum denser city roi results reveal annual household electricity consumption per capita two cities similar showing implications density however private transport energy consumption per capita chaiyaphum per cent higher supporting hypothesis less dense city higher transport energy consumption key factor identified greater distance travelled households located peri urban areas less dense city important policy implications urban planning urban development practices thailand
chagas disease still reaching million people world south america one severe forms disease megacolon characterized severe constipation dilated sigmoid colon rectum severe malnutrition previous data suggested mast cells serotonin hydroxytryptamine expression could involved intestinal homeostasis control avoiding chagasic megacolon development aim study characterize presence mast cells expression serotonin chagasic patients without megacolon evaluate relation mast cells serotonin megacolon development results demonstrated patients without megacolon feature large amount serotonin mast cells patients megacolon feature low serotonin expression lot mast cells believe serotonin may involved inflammatory process control triggered mast cells presence substance large quantities intestine could represent mechanism megacolon prevention
purpose objective study explore types innovation predominant smes whether predominantly radical incremental investigate impact innovations performance design methodology approach web based survey instrument used administer survey questionnaires sample smes manufacturing engineering electronics information technology telecommunications industries response rate percent relevant statistical analytical techniques including regression analysis used findings found smes tend focus incremental radical innovations focus related growth sales turnover practical implications bad idea smes particularly operating high technological industries focus incremental innovations actually related positively sales turnover growth originality value investigation types innovation smes pursue pioneering field previous studies type based large firms contention raison etre smes develop radical innovations supported empirically least sample smes addition found age sme related focus either incremental radical innovation contributions paper
family environments parenting associated inflammation immune activation children adolescents however remains unclear specific aspects parenting drive association study cross sectionally examined association discrete parenting styles inflammation immune activation late childhood data drawn families female children mean age years participating imaging brain development childhood adolescence transition study children provided saliva samples inflammation reactive protein immune competence activation secretory immunoglobulin measured parents completed alabama parenting questionnaire measures aspects parenting style positive parental involvement positive disciplinary techniques consistency disciplinary techniques corporal punishment monitoring supervision results showed higher scores poor parental monitoring scale associated higher levels inflammation immune activation children study highlights parental monitoring supervision specific aspect parenting behavior may important children physical mental health
person judgeability extent person easy understand plays important role accurately target perceived others research topic however systematic well integrated current review begins remedy integrating available research judgeability fields personality perception nonverbal communication social cognition specifically review summarizes characteristics likely promote judgeability explores potential consequences diverse range characteristics identified predictors judgeability relating three broader categories psychological adjustment social status socialization furthermore judgeable variety potential largely positive consequences target leaving good targets poised greater personal interpersonal well nevertheless many questions topic remain crucial relatively understudied topic receive systematic empirical attention
paper presents flexible low power read circuit roc tunable sensitivity designed interface wide range commercial resistive pressure sensors robotic applications roc provides contact detection monitoring small capacitance variations low pressure mbar encodes pressure measurement bit evaluating resistive variations two digital circuits implement conversion input resistance capacitance frequency exploiting chip ring oscillator timing reference rfcmos prototype active area power consumption vdd using digital control inputs roc allows wide range tuning measurement sensitivity mbar lsb adjustable acquisition time contact detection pressure evaluation respectively read time similar compatible human response touch
due positive effect flame propagation case well defined breakdown formation large scale tumble motion important goal engine development cycle cycle variations ccv tumble position strength however lead fluctuating tumble breakdown space time therefore combustion variations indicated ccv peak pressure work aims detailed investigation large scale tumble motion interaction piston boundary layer intake stroke state art gasoline engine allow validation flow near piston surface obtained simulation new measurement technique called flying piv applied detailed comparison experimental simulation results carried well analysis obtained flow field large scale tumble motion investigated based numerical data multiple highly resolved intake strokes obtained using scale resolving simulations method detect tumble center position within flow field extension previously developed algorithms presented applied used investigate phase averaged tumble structure characteristics terms angular velocity ccv individual intake strokes finally analysis presented piston boundary layer influenced tumble motion final phase intake stroke
millions workers worldwide exposed noise levels increase risk hearing impairment noise exposure cause several risks safety health workers however condition prevented preventive measures many countries hearing loss prevention programmes hlpps mandatory considered effective means prevent noise induced hearing loss awareness industry keep noise control engineering programs training programs inserted effective hearing conservation program essential protect worker objective work search effectiveness hearing loss prevention interventions hearing education programs hearing protection devices workers noise perception paper presents systematic review topic reports order identify papers published constant journals databases appropriate keywords combinations conclude studies conservation program evaluation used relatively studies mainly relation effects programs employees health safety
background patients sickle cell disease scd may experience many complications central nervous system cns including stroke silent cerebral infarcts neuropsychological deficits cranial epidural hematoma rare potentially serious complication procedure case series cranial epidural hematomas children scd three different institutions considered along literature review cranial epidural hematomas population results seven children scd cranial epidural hematomas identified three different institutions patients male age presentation ranged years two patients presented headache rest neurologic symptoms presentation four patients required urgent neurosurgical intervention one patient died literature review identified additional cases cranial epidural hematomas children scd treatment ranged supportive care neurosurgical intervention twelve patients completely recovered one patient long term cognitive impairment four patients died combined data cranial epidural hematomas mortality rate conclusions although rare cranial epidural hematoma fatal considered patients acute neurological symptoms
aimed develop validate fracture health search fra score prediction risk osteoporotic fractures primary care italy selected cohort patients aged years followed occurrence osteoporotic fracture death end data registration end data availability december age sex history osteoporotic fractures secondary osteoporosis long term use corticosteroids rheumatoid arthritis body mass index smoking alcohol abuse alcohol related diseases interaction terms sex use corticosteroids age secondary osteoporosis entered competing risk regression fine gray method predict risk hip femur overall major osteoporotic fractures coefficients combined obtain fra individual patients explained variance discrimination calibration measures computed evaluate models accuracy final model tested using independent data source fra explained variation occurrence hip femur overall major osteoporotic fractures respectively area curve respectively predicted observed ratios revealed margin error lower population stratifying sex prediction models hip femur fractures confirmed acceptable accuracy sexes poor explained variance observed overall major fractures findings indicate fra might implemented primary care risk prediction hip femur fractures general practitioners could therefore supported tool clinical decision making
based social projection research four studies investigated whether people rely regulatory focus making predictions others chronic study induced study regulatory focus shaped estimations others strategic promotion prevention inclinations choices enriched fitting promotion impoverished options fitting prevention providing indirect process evidence via boundary conditions participants relied induced regulatory focus predictions others inclinations seek romantic alternatives extent run counter stereotypic gender beliefs study addition participants relied induced regulatory focus preference predictions concerning promotion prevention products lacked idiosyncratic target knowledge study effects mediated mood judgment certainty perceived task enjoyment task difficulty implications findings social projection research well possible interpersonal consequences delineated
paper infinite horizon robust optimal control problem class continuous time uncertain non linear systems investigated using data based adaptive critic designs neural network identification scheme combined traditional adaptive critic technique order design nonlinear robust optimal control uncertain environment first robust optimal controller original uncertain system specified cost function established adding feedback gain optimal controller nominal system neural network identifier employed reconstruct unknown dynamics nominal system stability analysis hence data based adaptive critic designs developed solve hamilton jacobi bellman equation corresponding transformed optimal control problem uniform ultimate boundedness closed loop system also proved using lyapunov approach finally two simulation examples presented illustrate effectiveness developed control strategy
planning methodology introduced ensure workers construction sites remain safe distance methodology based assumption hazardous conditions occur sites due proximity different workers depend interaction reinforcing counteracting characteristics workers methodology includes matrix based method definition minimum safe distances workers use time space diagrams represent analyze dynamic movements workers site methodology implemented real case study order verify feasibility elsevier rights reserved
trigeminal ganglia subserving head dorsal root ganglia drg subserving rest body homologous handling sensory neurons differences exist number signaling substances cause headache pain rest body date genes involved difference identified aim reveal basal gene expression levels drg detect genes differentially expressed drg rna sequencing six naive rats describes whole transcriptome expression profiles drg differential expression analysis followed pathway analysis identify processes drg total genes higher genes lower expressed levels drg higher expressed genes including spr gjc related phospholipase activity lower expressed genes including several hox genes slca related tyrosine phenylalanine metabolism tissue specific expression identified gabra gabrd several hox genes drg furthermore genes known associated headache migraine mostly moderately highly expressed one tissues present comprehensive overview expression profiles whole tissue comparison drg showed genes pathways drg including several known migraine associated genes study provides basis pain related studies using drg rats ibro published elsevier ltd rights reserved
even though drought one common features affecting rainfed agriculture necessary consider extreme climatological event requires different types alleviating strategies overcoming risk involved successful cultivation crops depends nature drought chronic contingent probable duration frequency occurrence within season aberrations expected increase future significant fall food production often noticed increase intensity extension duration drought prevalence drought affects food production farm level also national economy overall food security location specific rainfed technologies available cope different drought situations much research done rainfed agriculture india relates conservation soil rainwater drought proofing key technologies drought mitigation situ moisture conservation rainwater harvesting recycling resilient crops cropping systems including contingency crop plans foliar sprays integrated farming systems however drought preparedness real time implementation contingency measures field level needs well structured institutional support farmers strong government policy convergence among various institutions ministry agriculture government india needs facilitate convergence process various government schemes mgnrega rkvy mega seed project nfsm nhm iwmp soil health schemes etc drought preparedness national mission sustainable agriculture nmsa one among missions prime minister national action plan climate change napcc may take lead role implementation contingency inclusion activity state action plans sap dedicated nodal institution officers budget provision
study aimed examine associations individual trajectories three types negative affect anxiety depression anger craving day period incentivized smoking abstinence period cessation outcome months year adult smokers completed questionnaire assessments craving pre quit baseline sessions postquit sessions days biochemically verified abstinence nicotine placebo patch treatment growth curve logistic regression analyses used examine associations trajectory parameters individual states craving abstinence outcomes months year postquit greater declines anxiety depression anger symptoms first days smoking cessation predictive higher odds abstinence months year moreover greater declines anxiety anger remained significant predictors abstinence time points independent predictive ability trajectory profiles craving findings suggest slower dissipation especially anxiety anger represents greater risk relapse smoking beyond predicted craving early abstinence thus temporal profiles affective symptoms convey unique motivational significance relapse reduction early abstinence may valid target interventions increase long term cessation success rates particularly among individuals refractory affective symptoms
due increasing incidence hymenoptera venom allergies potentially life threatening reactions important otolaryngologists working allergology understanding modern diagnostic treatment standards allergic disease molecular diagnosis recombinant single allergens bee wasp venom components improves diagnostics insect venom allergies particularly patients double positive extract based test results detection specific sensitizations bee wasp venom enables double sensitizations better distinguished cross reactivity based patient history test results patient initially advised avoidance strategies prescribed emergency medication kit indication allergen specific immunotherapy ait evaluated dose increase phase performed using conventional cluster rush ultra rush schedules whereby rapid desensitization rush ait performed clinic seems particularly effective initial treatment
community based participatory research cbpr become increasingly common approach research involving people use drugs pwud often employed peer researchers projects paper seeks understand impact cbpr pwud particularly living heavily researched stigmatized neighbourhoods cbpr projects often located study draws depth interviews pwud previous experience peer researchers research participants cbpr projects conducted july february study employed cbpr approach study design recruitment interviewing analysis analysis indicates participants supportive cbpr principle described ways helped contest stigmatizing assumptions researcher bias participants also reported positive personal gains participation cbpr projects however many participants negative experiences cbpr projects especially cbpr principles implemented superficial incomplete manner participants emphasized importance inclusiveness active deconstruction hierarchy researchers community members successful cbpr among drug using populations cbpr widely adopted research approach within marginalized communities often implemented inconsistently still cbpr empower communities contest forms social stigma often reproduced academic research marginalized communities findings describe benefits cbpr maximized cbpr principles consistently applied community based researchers supported ways reduce power hierarchies suggests need capacity building within affected communities develop independent support training grievance processes peer researchers elsevier ltd rights reserved
building information modelling bim received increased attention construction sector bim becoming widespread common approach design construction maintenance building facilities bim also one widely discussed topics academics professionals construction industry world purpose article present initial results studies use bim construction projects poland czech republic studies cover widely understood field management construction projects research concerns scale use bim construction project management awareness bim possibilities potential participants construction projects paper authors discuss results studies compare situation poland czech republic authors published elsevier ltd
objective childhood physical abuse cpa lead adverse mental health outcomes adulthood potential impact chinese populations still unclear meta analysis first examine association cpa mental health outcomes chinese populations study design studies published december identified embase cinahl scopus psycinfo pubmed chinese national knowledge infrastructure databases studies data association cpa mental health outcomes chinese subjects included twenty four studies initially identified two excluded poor quality two reviewers independently extracted data generate summary effect sizes using random effects meta analytic model priori subgroup sensitivity analyses performed evaluate heterogeneity bias studies results meta analysis studies found significant positive association cpa overall mental health outcomes among chinese subjects pooled effect size odds ratio confidence interval among community samples pooled effect size based diagnostic statistical manual mental disorders fourth edition text revision diagnostic criteria cpa strongly associated axis axis disorders conclusions detrimental effects cpa mental health outcomes chinese populations comparable west contrary chinese belief physical punishment safe way discipline children findings highlight potential harm mental health need change parenting practice
paper deals design implementation new curriculum manufacturing industrial engineering engineering management bachelor master degrees tlemcen university algeria curriculum aims give student multidisciplinary knowledge domain engineering technology well management implementation curriculum tlemcen university showed large improvement student skill permits become national curriculum authors published elsevier ltd
rainwater retention tank systems designed capture rainwater roof surfaces store effective water supply later use systems known rsd rainfall storage discharge systems involve three processes rainfall storage discharge develop design method process use water balance tank estimate control effect given volume rainwater tank retention also develop algorithm calculating nonlinear behavior stored water volume rainwater tank simulated flow variation tank simulated results represented form tank capacity peak outflow curves case storage tank per area installed roof surface buildings small area results show peak flow total outflow reduced respectively thus rsd systems useful controlling runoff rooftops effective reducing final discharge rate urban drainage system
two phase flows commonly found many industrial applications oil gas production monitoring flows performed either field applications pilot plant studies cases simple robust measuring techniques required capacitive probes applied void fraction measurement pipes research industry however capacitive measuring systems applied far tailored specific applications may easily adaptable addition soft computing methods applied advanced data processing parameter extraction requires computational power sensor systems online data processing develop capacitive system provided microcontroller necessary routines data processing may embedded system design detailed explained system performance evaluated showing appropriate accuracy time response investigation two phase flows elsevier ltd rights reserved
investigation paper generalized variable coefficient fifth order kortewegde vries equation describes interaction water wave floating ice cover gravity capillary waves via hirota method bell polynomial approach symbolic computation bilinear forms soliton solutions backlund transformation lax pair derived infinitely many conservation laws obtained based bell polynomial typed backlund transformation soliton fusion fission influence variable coefficients equation analyzed variable coefficients direct proportion soliton velocities effect amplitudes another constant coefficient affect types interactions sense elastic inelastic elastic inelastic interactions among three solitons presented well elsevier inc rights reserved
past year automation become important field elemental structural chemical analysis reduce high degree manual operation processing time well human errors thus high number data points generated requires fast automated data evaluation handle preprocessed export data different analytical devices software various vendors offering standardized solution without programming knowledge preferred modern laboratories multiple users use software multiple personal computers different operating systems windows macintosh linux also mobile devices smartphones tablets gained growing importance developed software project analytical data evaluation ade implemented web application transmit preevaluated data device software project ade exported xml report files detected included data imported entities database using data upload software different calculation types sample within one measurement series method validation identified using information tags inside sample name results presented tables diagrams different information levels general detailed one analyte sample
paper proposes novel carbon dioxide transcritical power cycle combined absorption refrigeration cycle cdtpc arc recover waste heat jacket water exhaust gas heavy duty ices firstly detailed study conducted investigate effects key operating parameters performance cdtpc arc secondly comparative study proposed cdtpc arc existing cdtpc consisting cdtpc regenerator cdtpc without regenerator waste heat conditions shows cdtpc arc produce approximately constant net power output net degrees cdtpc operate transcritical power cycle degrees finally parametric optimization performed achieve maximum net combined cycles using genetic algorithms results show cdtpc arc produce net larger recycle efficiency compared cdtpc degrees degrees net cdtpc arc higher cdtpc corresponding eta rec higher cdtpc addition economic performance comparison two cycles performed results show cdtpc arc better economic performance elsevier ltd rights reserved
paper proposes innovative strategy optimize energy metering large energy consuming plants industrial flour mills proposed solution deals iso implementation represents critical challenge many companies benefits due improvements energy management could potentially canceled costs energy management system enms particular key performance indexes kpis monitoring crucial activity several reasons one early activities affects measurement quality kpis deeply impacts enms requirements consequently investment valuations proposed strategy supports energy managers design energy monitoring system suggesting points electrical network equipped sensors monitored moreover paper describes results carried real world application energy sensor network flour mill plant sited italy designed implemented proposed innovative solution
background pregnancy associated osteoporosis pao lead serious difficulties fragility fractures elongated back pain height loss affected women soluble receptor activator nuclear factor kappa ligand srankl osteoprotegerin opg ratio chosen bone metabolism equation many bone diseases characterized bone resorption post menopausal osteoporosis would modified folic acid supplementation study done compare effects high dose day low dose day folic acid rankl opg ratio tumor necrosis factora tnf alpha concentration pregnancy methods forty five pregnant women visited zahra hospital tabriz iran september november assigned two groups randomized double blind clinical trial included women took day group took day group folic acid supplementation pregnancy pregnancy biochemical variables serum pregnant women measured end study study registered iranian registry clinical trials irct irctn results opg levels significantly higher compared baseline value although srankl tnfa srankl opg ratio reduced significantly high dose folic acid supplementation significant positive correlation observed decreased rankl tnfa levels end study high dose group conclusion high dose folic acid supplementation could decrease bone resorptive biomarkers may prevent pao pregnant women increasing opg decreasing srankl tnfa
investigated information women diagnosed breast cancer young age would want learn genome sequencing results returned conducted semi structured interviews women diagnosed breast cancer age younger examined specific information participants would want learn across result types type result well much information would want genome sequencing offered participants part study two coders independently coded interview transcripts analysis conducted using nvivo across result types participants wanted learn health implications risk prevalence quantitative terms causes variants causes diseases participants wanted learn actionable information variants affecting risk preventable treatable disease medication response carrier status amount desired information differed variants affecting risk unpreventable untreatable disease uncertain significance health related women diagnosed breast cancer young age recognize value genome sequencing results identifying potential causes effective treatments expressed interest using information help relatives understand health risks findings inform development effective feedback strategies genome sequencing meet patients information needs preferences
brief glance object shape appreciate rich suite functional properties including organization object parts optimal contact points grasping center mass balancing point however real world laboratory balance perception shows systematic biases whereby observers may misjudge shape center mass severe margin biases simply quirks physical reasoning might instead reflect fundamental principles object representation demonstrate systematically biased center mass estimation two dimensional shapes study advance surprising explanation biases suggest mind implicitly represents ordinary shapes rich volumetric three dimensional objects inflated shape representations intrude bias perception shape geometric properties inflation computer graphics technique segmenting shapes parts show model derived technique best accounts biases center mass estimation study supporting account show reducing need inflated shape representations diminishes biases center mass estimation improved cues shapehood attenuated study shapes depths explicitly depicted using real life objects laser cut wood study suggest technique shape inflation actually implemented mind thus biases impressions balance reflect general functional characteristic object perception
lhcb detectors upgraded next lhc shutdown tracker system undergo major changes components replaced new technologies order cope increased hit occupancy higher radiation dose detector made scintillating fibres read silicon photomultipliers sipm envisaged upgrade even technology proven achieve high efficiency spatial resolution integration within lhc experiment bears new challenges detector consist planes layers fibres stacked covering total area desired spacial resolution reconstructed hit sipms adapted detector geometry reducing dead area channels total channels arranged single die common cathode connection channel size two dies packaged together dead area radiation tolerance devices important challenge operation low temperatures crucial achieve desired performance several manufacturers produced prototypes testing different characteristics form factor size leads total channels need read mhz pacific asic readout sipms interface components devices asic handle channels analog signal processing digitization last prototype comprises channels first stage current conveyor followed fast shaper approximate cope signal arrival times gated integrator digitization done using bits non linear flash adc operating mhz power consumption kept bellow per channel
high quality xcux compounds successfully prepared method combining solid solution sintering process paper prepared xcux compounds exhibit reversible hydrogen desorption process strongly subject content depending instance compound absorbs hydrogen form mgni mgcu moreover based structural analysis maximum solid solubility xcux determined first time solid solubility thus leads significant decrease delta value mol mgnih mol mgni result provides efficient route destabilizing hydrogen desorption mgni based materials elsevier rights reserved
alcohol related aggression complex problematic phenomenon profound public health consequences examined neural correlates potentially moderating relationship human aggressive behavior chronic alcohol use thirteen subjects meeting dsm criteria past alcohol dependence remission matched healthy controls cont participated fmri study adapted laboratory model human aggressive behavior point subtraction aggression paradigm psap blood oxygen level dependent bold activation measured bouts operationally defined aggressive behavior postprovocation periods monetary reinforced behavior whole brain voxelwise random effects analyses found group differences brain regions relevant chronic alcohol use aggressive behavior emotional behavioral control behaviorally subjects responded aggressive response monetary response options significantly higher rates cont whole brain voxelwise random effects analyses revealed significant group differences response provocation monetary subtractions cont subjects showing greater activation frontal prefrontal cortex thalamus hippocampus collapsing data across subjects regression analyses postprovocation brain activation aggressive response rate revealed significant positive regression slopes precentral gyrus parietal cortex significant negative regression slopes orbitofrontal cortex prefrontal cortex caudate thalamus middle temporal gyrus collapsed analyses response provocation aggressive behavior associated activation brain regions subserving inhibitory emotional control sensorimotor integration goal directed motor activity
finite element method fem common numerical technique used solving partial differential equations large unstructured domain geometries numerical methods fem typically use algorithms data structures exhibit unstructured memory access pattern makes acceleration fem field programmable gate arrays using efficient deeply pipelined architecture particularly challenging work focus implementing optimising vector assembly operation context fem induces unstructured memory access propose dataflow architecture graphbased theoretical model design flow optimising assembly operation spectral finite element method reconfigurable accelerators evaluate proposed approach two benchmark meshes show graph theoretic method generating static data access schedule results significant improvement resource utilisation compared prior work enables supporting larger fem meshes fpga previously possible
individuals borderline personality disorder bpd characterized emotional instability impaired emotion regulation unresolved attachment patterns associated abusive childhood experiences investigated neural response activation attachment system bpd patients compared healthy controls using functional magnetic resonance imaging writ eleven female patients bpd without posttraumatic stress disorder ptsd healthy female controls matched age education telling stories scanner response adult attachment projective picture system aap eight picture set assessment adult attachment picture set includes theoretically derived attachment scenes separation death threat potential abuse picture presentation order designed gradually increase activation attachment system picture stimulus presented min analyses examine group differences attachment classifications neural activation patterns course task unresolved attachment associated increasing amygdala activation course attachment task patients well controls unresolved controls patients showed activation right dorsolateral prefrontal cortex dlpfc rostra cingulate zone rcz interpret neural signature bpd patients inability exert top control conditions attachment distress findings point possible neural mechanisms underlying affective dysregulation bpd context attachment trauma fear
arterial hypertension htn atrial fibrillation often coexist combination two conditions carries increased risk stroke htn one important risk factors included scores stoke prediction atrial fibrillation used assess need anticoagulation htn also strictly related bleeding complications antithrombotic therapy antithrombotic drugs options include vitamin antagonists new oral anticoagulants recently approved stroke prevention nonvalvular atrial fibrillation favorable new oral anticoagulant efficacy safety compared warfarin reported hypertensive patients making drugs first line choice population prevent cerebrovascular events reduce risk major bleedings aim review explore relationship among htn atrial fibrillation risk stroke summarize evidence impact htn choice appropriate anticoagulation treatment
grounding grid substation vital preserving safety reliability power system protecting operator electrical equipment material grounding grid usually flat steel country grounding grid buried deeply ground making susceptible corrosion failure based fault diagnosis theory electrical network theory writer establishes grounding grid fault diagnosis equation solves equation optimization algorithm finally writer gets proportion branch change resistance
aimsthe search novel drugs enhance myelin repair entities multiple sclerosis top priority neurological research least remyelination hinder neurodegeneration neuro inflammatory conditions recently several new compounds potential boost remyelination identified using high throughput vitro screening methods however assessing potential enhance remyelination vivo using plastic embedded semi thin sections electron microscopy even though gold standard assessing remyelination toxic extremely time consuming expensive methodswe screened available myelin dyes staining candidate offers faster easier alternative visualize remyelination cryo sections resultswe identified sudan black candidate excellent myelin resolution show adapted sudan black staining demonstrate myelin repair rodent spinal cord cryosections reliable semithin sections much faster easier less toxic less expensive besides resolve small myelinated axons corpus callosum staining yet readily combined immunostainings challenging semithin sections validated method human spinal cord tissue well experimental demyelination rat spinal cord lysolecithin time course experiment proof principle demonstrate sudan black able reliably detect remyelination enhancing properties benztropine conclusionour adapted sudan black staining used rapidly non toxically screen remyelinating therapies demyelinating diseases
introduce class preconditioners general sparse matrices based birkhoff von neumann decomposition doubly stochastic matrices preconditioners aimed primarily solving challenging linear systems highly unstructured indefinite coefficient matrices present theoretical results numerical experiments linear systems variety applications
use composite materials industry applications constantly growing however fault detection prediction materials simple traditional materials thus development methodology fault detection strictly necessary ensure integrity structure paper proposes pattern recognition system implements artificial neural network classifier detect classify damage composite beams classifiers trained tested using acoustic signals emitted healthy damaged beams impulsive load applied singular value decomposition used filter acoustic signals whereas principal component analysis implemented extract relevant information filtered signal extracted information used inputs classifier able predict four different levels damage glass fiber carbon fiber beams accuracy results suggest proposed methodology investigated develop robust system automatic detection damage composite structures elsevier masson sas rights reserved
recent years data mining become popular technique extracting information databases many types different areas commerce industry strength data mining comes flexibility working kind database ability discover previously unknown sometimes surprising results competitiveness increasingly depends improving quality decision making past information improved knowledge engineering capabilities products enables engineers better target future production strategies move quality control quality assurance reduced error occurrence companies need exploit existing knowledge previous experiences effectively data mining analysis offers many potential benefits context paper briefly highlights benefits gained application data mining technology different sectors pakistan general engineering sector particular
wconfirms accuracy robustness proposed fft model root mean square errors fft blind predictions benchmark set complexes pdb bind core set complexes pdbbind core set complexes kcal mol respectively corresponding pearson correlation coefficients respectively present feature functional theory binding predictor fft protein ligand binding affinity prediction underpinning assumptions fft follows representability exists microscopic feature vector uniquely characterize distinguish one protein ligand complex another feature function relationship macroscopic features including binding free energy complex functional microscopic feature vectors similarity molecules similar microscopic features similar macroscopic features binding affinity physical models implicit solvent models quantum theory utilized extract microscopic features machine learning algorithms employed rank similarity among protein ligand complexes large variety numerical validations tests
epigenetic changes reln involved development dopaminergic neurons may fit developmental theory schizophrenia however evidence regarding association reln dna methylation schizophrenia far sufficient studies conducted limited brain samples dna methylation peripheral blood may mirror changes taking place brain use peripheral blood dna methylation study schizophrenia feasible due scarcity brain samples therefore aim study examine relationship dna methylation levels reln promoters schizophrenia using genomic dna derived peripheral blood patients disorder case control studies consisted schizophrenia participants healthy controls recruited district bisufhite conversion methylation levels dna samples calculated based differences values assayed using highly sensitive real time methylight taqman procedure significantly higher level methylation reln promoter found patients schizophrenia compared controls also males compared females subsequently reln expression methylated group fold less non methylated group based upon assumption parallel methylation changes brain peripheral blood concluded reln dna methylation might contribute pathogenesis schizophrenia however definite effects methylation reln function development also adult life still require elaboration elsevier ltd rights reserved
living organisms depend homeostasis complex set interacting metabolic chemical reactions maintaining life well less true psychiatric well physical well indeed focus homeostasis forces see inextricably linked mental physical well paper focuses linkages particular addresses ways understanding disturbed homeostasis may aid creating classes patients mood anxiety disorders based phenotypes cellular level may able compensate inability study living brain tissue study homeostatic mechanisms fibroblasts pluripotent human cells mitochondria determine homeostasis disturbed level peripheral tissues exogenous stress also emphasize remarkable opportunities enhancing knowledge area offered advances technology study human behavior especially combined greatly improved capacity study unique isolated populations offers particularly clear windows relationships among genetic environmental behavioral contributions homeostasis
objectives boswellic acid compound isolated gum resin boswellia carterii pentacyclic terpenoid active many inflammatory diseases including cancer arthritis chronic colitis ulcerative colitis crohn disease memory impairment mechanism poorly understood study investigated effects boswellic acid spatial learning memory impairment induced trimethyltin tmt wistar rats methods forty male wistar rats randomly divided groups normal group tmt administrated rats intraperitoneally tmt administrated rats used daily days evaluate cognitive improving performed morris water maze test moreover investigate neuroprotective effect determined acetylcholinesterase ache activity malondialdehyde mda level marker lipid peroxidation glutathione gsh content cerebral cortex results treatment tmt impaired learning memory treatment dose produced significant improvement learning memory abilities water maze tasks consistent behavioral data activity ache significantly increased tmt injected rats compared control group whereas groups treated presented significant inhibitory effect ache tmt injected animals addition tmt reduced gsh content increased mda level cerebral cortex compared control group hand treatment slightly increased gsh content reduced mda level comparison tmt administered group conclusion results suggest effect improving cognitive function may mediated antioxidant activity
objective identify subgroups children special health care needs cshcn characterize key outcomes data source secondary analysis national survey cshcn study design latent class analysis grouped individuals substantively meaningful classes empirically derived measures pediatric medical complexity outcomes compared among latent classes weighted logistic negative binomial regression principal findings lca identified four unique cshcn subgroups broad functional impairment physical cognitive mental health extensive health care class broad functional impairment alone class predominant physical impairment requiring family delivered care class physical impairment alone class cshcn class highest visit rates irr hospitalization odds aor lowest odds medical home aor cshcn class despite experiencing shared decision making medical home attributes visits missed school cshcn class latter however experienced cost related difficulties care delays parents stop work conclusions recognizing distinct impacts cognitive mental health impairments health care delivery needs cshcn outcomes may better direct future intervention efforts
means share knowledge community question answering cqa service provides users chance obtain provide help raising answering questions question posted system must find appropriate individual answer question several approaches recently proposed find experts cqa paper new method find experts cqa proposed considering user post contents answer votes ratio best answers user relation votes used post relation analysis calculate user authority user knowledge score calculated topic analysis considering question usually includes many trivial words accurate distribution nearly impossible obtain lda solve problem vocabulary extended including link information shown question top relevant words wikipedia provided tag tag lda models user topic distribution predicts topic distribution new questions experiment conducted stack overflow dataset world largest computer programming cqa site experimental results showed approximately performance improvement ndcg metrics
strategies investigated increased cylinder formation hydrogen use low intake oxygen post injection proposed intake oxygen sweep conducted lean burn compression ignition engine adjusting exhaust gas recirculation rate results revealed yield hydrogen increased exponentially intake oxygen reduced achieve low temperature combustion tests showed low temperature combustion operation consistently produced hydrogen high temperature combustion similar air fuel ratios increase hydrogen yield post injection timing sweep carried low temperature combustion operation increased yields hydrogen obtained volume post injection timing advanced degrees crank angle top dead centre time indicated nox emissions reduced smoke emissions fsn thus tests established combination low temperature combustion low intake oxygen early post injection produced high yield hydrogen simultaneously ultra low nox smoke emissions main drawback strategy increased formation methane ppm volume however analysis showed hydrogen methane ratio actually increased low temperature combustion operation hydrogen energy publications llc published elsevier ltd rights reserved
background bath psoralen plus ultraviolet light puva therapy effective safe inexpensive treatment psoriasis psoriasis might due unbalanced ratio cells regulatory cells treg treg functional ratio significantly lower patients psoriasis compared controls inversely correlated psoriasis area severity index score previously reported bath puva therapy significantly increases number treg restores treg function almost normal patients psoriasis objectives examined effects bath puva therapy three distinct foxp subsets activated treg atreg resting treg rtreg cytokine secreting non suppressive cells methods enrolled patients psoriasis healthy controls examined atreg rtreg cytokine secreting non suppressive cells peripheral blood obtained psoriasis patients every fifth bath puva therapy session results levels atreg considered strongest suppressive activity patients psoriasis significantly increased early bath puva therapy sessions diminished levels rtreg lower psoriasis patients healthy controls increased bath puva therapy conclusions bath puva therapy induced atreg rtreg concomitantly improvement psoriatic lesions suggesting mechanism effectiveness bath puva therapy psoriasis patients japanese society investigative dermatology published elsevier ireland ltd rights reserved
purpose paper aims reveal functioning project delivery systems nearly zero energy building nzeb projects focus set reveal qualities systems support nzeb goals sustainability design methodology approach research method used paper inductive reasoning reasoning based existing literature conclusions drawn combining pieces literature findings state art heating ventilation air conditioning hvac insulation requirements nzeb technology lack experience industry regarding nzeb projects suggest modern collaboration based project delivery systems favoured authors found suitable project delivery system standard nzeb project integrated project delivery ipd binds financial goals main parties together via reimbursement solution target pricing authors also found construction management risk system suitable solution especially modified adding tools utilised ipd approach thereby making ipd lite system originality value paper value entire construction industry finland european union owners construction companies use findings development efforts towards nzeb construction nzeb degree makes findings concerning practicalities nzeb projects valuable due lack time lack experience industry
last years prevalence food allergy rise remains disease significant impact quality life children families several hypotheses suggested account increasing prevalence review focus impact dietary factors food allergy development past food allergy prevalence largely focused allergen avoidance however increasing evidence interventional studies shown early introduction potential food allergens may beneficial role allergy prevention review aims look evidence support early introduction allergens infant diets prevent development food allergy
backgroundhereditary angioedema normal inh may linked specific mutations coagulation factor fxii gene hae fxii mutations genes still unknown hae unknown assess differences transmission inheritance clinical features laboratory parameters patients hae fxii hae unknown methodssixty nine patients hae fxii unrelated families patients hae unknown unrelated families studied resultsboth hae fxii hae unknown inherited autosomal dominant traits incomplete penetrance male female ratio hae fxii hae unknown maternal paternal transmission ratio hae fxii hae unknown mean age onset clinical symptoms years patients hae fxii years patients hae unknown incidence asphyxiation due angioedema similar hae fxii hae unknown oral contraceptives pregnancies significantly higher impact hae fxii hae unknown slightly decreased inh activity concentration observed patients hae fxii hae unknown tests fxi fxii activity plasminogen activator inhibitor activated partial thromboplastin time showed variability significant differences groups abnormalities found inh protein alpha macroglobulin antithrombin iii angiotensin converting enzyme families hae fxii number female offspring mutations significantly increased male offspring significantly decreased conclusionshae fxii hae unknown differ various respects including gender distribution genetics symptoms estrogen impact
social anxiety eating disorders highly comorbid several explanations high levels comorbidity theorized first social anxiety might vulnerability factor eating disorders second eating disorders might vulnerability factor social anxiety third two kinds disorders may common shared psychological vulnerabilities current study undergraduate women investigates model social anxiety eating disorder symptoms examines possibilities across two time points time six months later find support either social anxiety eating disorder symptoms per predicting across time instead find underlying vulnerabilities prospectively predict symptoms disorders whereas vulnerabilities specific symptoms one disorder specifically find maladaptive perfectionism shared prospective vulnerability social anxiety eating disorder symptoms alternatively find social appearance anxiety specific eating disorder symptoms whereas high standards specific social anxiety symptoms data help clarify understanding social anxiety eating disorder symptoms frequently occur elsevier ltd rights reserved
introduction testosterone deficiency increases cardiovascular disease cvd risk aim evaluate effect erectile dysfunction sexual frequency hypogonadal symptoms cvd risk methods total hypogonadal men aged years surveyed using androgen deficiency aging male international index erectile function main outcome measures year cvd risk measured framingham risk score logistic regression performed obtain odds ratios sexual function hypogonadal symptoms year cvd risk high risk results mean age years mean year cvd risk whole cohort subjects classified high risk logistic regression revealed severity associated cvd risk mild moderate moderate severe compared sexual frequency decreased risk high cvd risk loss libido less strong erection increased risk high cvd risk remained significant adjustment age testosterone conclusions decreased sexual frequency loss libido predict high year cvd risk hypogonadal men
residues organochlorine pesticides ocps detected water sediment liver tissue samples common carp cyprinus carpio linnaeus collected ataturk dam lake ethoxyresorufin deethylase glutathion transferase glutathion reductase superoxide dismutase catalase carboxylesterase activities evaluated liver cyprinus carpio level ocps determined gas chromatography mass spectrometry pesticide residue determined water samples residues sediments higher fish wet season level pesticides higher dry season concentrations ocps highest akyazi bozova areas enzyme analysis results showed activities different region region generally higher akyazi bozova areas study first study determines levels ocps sediment water fish ataturk dam lake presents pesticide residue levels fish samples maximum residue limits could threat human health presence ocps indicates need continuous monitoring lake fish population safeguard health consumers
possibility handling uncooperative objects objects equipped features aid manipulation particular interest terrestrial space robotic applications framework paper deals development testing smart material substrate integrated end effector device morphing electro adhesive capabilities combined allow manipulation uncooperative objects different shapes materials compliance adhesion properties obtained creating conductive pattern electrodes embodied surface polymeric substrate one hand polymeric material activated change temperature adapt shape heated maintain deformed shape cooled even load removed becoming compliant objects surface hand conductive pattern responsible adhesive effect high voltage applied electric field generated induces opposite charge objects surface establishing reversible attraction forces furthermore conductive pattern could used activate morphing behaviour manipulator target object come contact resistive electroadhesive pad realized tests performed verify heating behavior electrodes electroadhesion forces achievable morphing tests also performed verify ability polymeric substrate maintain deformed shape cooling
generalized variable coefficient kdv equation perturbed external force terms investigated letter lax pair riccati type auto backlund transformation wahlquist estabrook type auto backlund transformation constructed based nonlinear superposition formula obtained infinite number conservation laws derived recursively analytic solutions provided including periodic one soliton like two soliton like solutions inhomogeneous coefficients external force term eigenvalue elsevier ltd rights reserved
distributed power systems using inverters connected parallel becoming increasingly widespread development autonomous microgrids inverters controlled emulate dynamics nonlinear oscillators multiple inverters coupled electrical network synchronize share load proportion ratings paper communication less control method developed islanded parallel inverters based van der pol oscillator virtual impedance technique controller tuned guarantee fast synchronization inverters well optimal load power sharing regardless differences physical parameters inverters respective filters methodology parameter selection presented tune controller system voltage amplitude remains within prescribed bounds whilst ensuring optimal load sharing minimizing synchronization time simulation results demonstrate performances obtained several parallel connected inverters using control method correctly tuned parameters
green building materials becoming popular however little known ability support limit microbial growth growth fungi evaluated five building materials two green two conventional building materials wood positive control selected materials inoculated aspergillus versicolor cladosporium cladosporioides penicillium brevicompactum absence presence house dust microbial growth assessed four different time points cultivation determining fungal biomass using acetylhexosaminidase naha enzyme assay clear differences seen green conventional building materials susceptibility support microbial growth presence dust external source nutrients promoted growth fungal species similarly green conventional materials results also showed correlation coefficient ranging naha activity culturable counts results suggest growth microbes material surface depends availability organic matter rather classification material green conventional naha activity culturability correlated well indicating two methods used experiments gave similar trends growth fungi material surfaces
systems parallel beams connected springs appear often engineering typical examples bundles wires ones appearing suspension bridge cables connections result coupling differential equations describing problem paper two systems parallel beams connected springs perpendicular beams examined multiple beams connected springs multiple beams common stiffness connected springs subjected common tensile axial load method proposed decouple system coupled equations uncoupled differential equations exact shape functions constructed computational effort associated systems involving large number beams become manageable numerical examples presented demonstrating capabilities proposed method
component method introduced steel construction institute predict moment resistance partial strength connection design philosophy taken directly eurocode strength checks bolts welds steel modified comply accuracy method however needs validated experimental tests especially hot rolled sections typical british section six experimental tests beam column connections carried flush end plate fep connections consisting variable parameters thickness end plate size number bolts size columns beams tests set using local hot rolled steel sections known perwaja section beams columns instead typical british section strength materials end plate column beam sections tested tensile strength used predicting moment resistance component method moment versus rotation test results plotted compared moment resistance derived component method study concluded moment resistance tested flush end plate connections higher predicted moment resistance component method showed good agreement two moments study also concluded tested fep connections met requirements criteria partial strength connections
traumatic brain injury tbi common cause death disability young adults consequences ranging physical disabilities long term cognitive behavioral psychological social defects recent data suggest pituitary hormone deficiency infrequent among tbi survivors prevalence reported hypopituitarism following tbi varies widely among published studies common cause tbi motor vehicle accidents including pedestrian car bicycle car encounters falls child abuse violence sports injuries prevalence hypopituitarism total isolated pituitary deficiency ranges time interval tbi pituitary function evaluation one major factors responsible variations prevalence hypopituitarism reported endocrine dysfunction tbi children adolescents common adolescence time growth freedom adjustment consequently tbi also common group sports related tbi important public health concern many cases unrecognized unreported sports associated increased risk tbi include involving contact collisions boxing football soccer ice hockey rugby martial arts well high velocity sports cycling motor racing equestrian sports skiing roller skating aim paper summarize best evidence tbi cause pituitary deficiency children adults
first paper present digital redesign method conventional okid system apply novel technique nonlinear system identification first observer kalman filter identification okid method used obtain lower order state space model stochastic chaos system digital redesign approach high gain property applied improve replace observer identified okid therefore proposed okid combined observer based digital redesign novel tracker suppresses uncertainties nonlinear perturbations also improves accurate observation parameters okid complex multi input multi output systems research chen stochastic chaotic system used illustrative example demonstrate effectiveness excellence proposed methodology
parallel matheuristic algorithm presented spin exact branch fix coordination bfc algorithm solving multistage stochastic mixed problems steps guarantee solution optimality relaxed bfc algorithm incomplete backward branching scheme considered solving large sized problems additionally new branching criterion considered based dynamically guided stage wise ordering schemes fewer twin node families expected visited execution called dbfc algorithm inner parallelization dbfc new approach allows solve parallel scenario clusters mip submodels different steps algorithm outer parallel version dbfc considers independent paths allows iterative incumbent solution values exchanges obtain tighter bounds solution value original problem broad computational experience reported assessing quality matheuristic solution large sized instances instances dimensions considered two orders magnitude larger works aware optimality gap dbfc solution value versus one obtained state art mip solver small new approach frequently outperforms terms solution quality computing time comparison stochastic dynamic programming algorithm also reported use parallel computing provides one hand perspective solving large sized instances hand expected large reduction elapsed time elsevier rights reserved
wireless sensor actuator networks wsans become pervasive used many embedded intelligent systems however complexity applications based networks limited due lack tools designing distributed systems top wsans paper present system level programming language systemj used develop middleware free ambient intelligence ami system system consists combination internet enabled stationary mobile wsan nodes resembles internet things scenario distributed warehouse monitoring control scenario collaborating stationary mobile wsan nodes used motivating example designed implemented systemj example demonstrates capabilities systemj designing distributed ami systems inherent support reactivity composition concurrent behaviors based formal model computation without need additional middleware approach compared existing software agent robotic wsan middleware approaches designing type systems
objective aim study evaluate efficacy acceptability second generation vaginal laser treatment vaginal erbium laser nonablative photothermal therapy management genitourinary syndrome menopause postmenopausal breast cancer survivors methods study performed using erbium laser crystal yttrium aluminum garnet fotona smooth fotona ljubljana slovenia wavelength forty three postmenopausal breast cancer survivors treated three laser applications every days symptoms assessed treatment months using two methods subjective visual analog scale vas objective vaginal health index score vhis procedures performed outpatient basis without anesthesia drug use intervention results baseline values vaginal dryness vas scores third treatment months treatment basal values whereas months last laser application basal values baseline values dyspareunia vas values decreased third treatment months last laser application basal values whereas months last laser application basal values vhis baseline values third treatment months last laser application basal values whereas months last laser application basal values adverse events recorded study conclusions study suggests vaginal erbium laser effective safe treatment genitourinary syndrome menopause breast cancer survivors
limited specific data investigations available diagnosis invasive fungal infection ifi paediatrics cancer patients three non invasive tests platelia aspergillus eia galactomannan glucan bdg assay pan fungal real time pcr fungal dna blood evaluated one hundred twenty five paediatrics cancer patients high risk ifi enrolled single blood serum samples evaluated three methods patients classified proven probable ifi cases accordance eortc msg revised guidelines sensitivity specificity ppv npv three tests proven probable ifis cases analysed singly combination sensitivity specificity ppv npv bdg pan fungal real time pcr bdg pcr among different combinations best combination found pcr sensitivity specificity ppv npv respectively single samples must evaluated combination tests
objective aim study examine eye gaze patterns patients physicians electronic health records used support patient care background eye gaze provides indication physician attention patient patient physician interaction physician behaviors searching information documenting information methods field study conducted patient visits observed video recorded primary care clinic videos coded gaze behaviors patients physicians gaze artifacts electronic health records coded using pre established objective coding scheme gaze data analyzed using lag sequential methods results results showed several eye gaze patterns significantly dependent doctor initiated gaze patterns followed patient gaze patterns patient initiated gaze patterns also followed doctor gaze patterns significantly unlike findings previous studies health information technology appears contribute new significant patterns emerged differences also found gaze patterns related technology differ patterns identified studies paper charts several sequences related patient doctor technology also significant electronic health records affect patient physician eye contact dynamic differently paper charts conclusion study identified several patterns patient physician interaction electronic health record systems consistent previous studies physician initiated gaze important driver interactions patient physician patient technology published elsevier ireland ltd
intrusion detection wireless mobile networks without infrastructure great importance dynamic structure non central locations limited resources nodes due characteristics wireless sensor network similarities natural communities found natural communities working together something much bigger handle reason seems natural communities used model wireless sensor networks systems mechanism matched wireless sensor network help particle swarm algorithm intrusion detection system problems like falling local optimality trap slowness convergence rate solved given important elements affect network security investigated model study evaluates energy throughput metaheuristic algorithms particle swarm genetic glowworm occur natural communities since sensor nodes network critical since numerous attacks put networks safety danger terms activity active passive study also used active attacks help simulator matlab software also impact metaheuristic algorithms wireless sensor networks considered assess lifetime nodes wireless sensor network
although sustainability movement healthcare sector initiated response ecological concerns green hospitals expected outperform traditional hospitals variety levels impacts environmental quality patients caregivers demonstrated numerous studies however still lack evidence benefits green hospitals respect different dimensions patients experiences study data public hospital consumer assessment health plans survey used compare performance green hospitals average performance traditional hospitals study included green hospitals found patients hospitalized green facilities reported overall higher ratings traditional hospitals compared average performance traditional hospitals similar sizes locations additionally patients green hospitals likely recommend hospital friends family however relationships specific green building features patient experiences identified study
introduction individuals syndrome exhibit alzheimer disease neuropathology dementia early life blood biomarkers neuropathology would valuable non intellectual disabilities dementia overlap clinically hypothesized elevations amyloid beta beta peptides phosphorylated tau neuronal exosomes may document preclinical methods neuropathogenic proteins beta tau tau quantified enzyme linked immunosorbent assays extracts neuronal exosomes purified blood individuals age matched controls results neuronal exosome levels beta tau tau significantly elevated individuals compared age matched controls ages beginning childhood significant gender differences observed discussion early increases beta tau tau individuals may provide basis early intervention targeted treatments become available published elsevier inc behalf alzheimer association
aim oxytocin regulates food intake carbohydrate lipid metabolism urinary sodium excretion assessed association serum oxytocin levels presence metabolic syndrome mets older men methods cross sectional study performed volunteer men aged yrs minos cohort oxytocin measured fasting serum radioimmunoassay oxytocin ria phoenix pharmaceuticals mets diagnosed using harmonized definition results serum oxytocin higher men mets controls adjustment confounders including leptin higher oxytocin associated higher odds mets per median higher odds mets men oxytocin total testosterone nmol higher odds mets men without characteristics men hydroxycholecalciferol levels higher odds mets men without characteristics osteocalcin levels lowest quartile higher odds mets men without characteristics conclusion older men higher serum oxytocin levels associated higher odds mets regardless potential confounders elsevier ireland ltd rights reserved
multi view image based rendering consists generating novel view scene set source views general works first coarse reconstruction scene using reconstruction establish correspondences source target views followed blending warped views get final image unfortunately discontinuities blending weights due scene geometry camera placement result artifacts target view paper show avoid artifacts imposing additional constraints image gradients novel view propose variational framework energy functional derived optimized iteratively solving linear system demonstrate method several structured unstructured multi view datasets show numerically outperforms state art methods eliminates artifacts result visibility discontinuities
objectiveto perform literature review epidemiology clinical presentation diagnostic evaluation clinical course occipital condyle syndrome including new case report backgroundoccipital condyle syndrome ocs rare clinical syndrome consisting unilateral occipital headache accompanied ipsilateral hypoglossal palsy headache typically radiates temporal region triggered contralateral head rotation usually associated skull base metastasis often unrevealed basic neuroimaging studies ocs might first manifestation malignancy unfamiliarity lead delay diagnosis methodswe performed systematic literature review using pubmed embase ocs along new case report resultsa total cases mean age years range men presented typical unilateral headache followed ipsilateral hypoglossal palsy days headache presentation patients initial neuroimaging studies normal ocs due skull base metastasis cases patients ocs first symptom disease conclusionsocs represents warning sign requires exhaustive search underlying neoplasm appropriate clinical evaluation lead earlier diagnosis patients consistent headache
introduction longitudinal imaging neurodegenerative disorders potentially powerful biomarker use clinical trials alzheimer disease studies demonstrated empirically derived regions interest rois provide reliable measurement disease progression compared anatomically defined rois methods set derive rois optimal effect size quantifying longitudinal change hypothetical clinical trial comparing atrophy rates patients behavioral variant frontotemporal dementia bvftd semantic variant primary progressive aphasia svppa nonfluent variant ppa nfvppa atrophy cognitively healthy controls results regions identified variant generally would expected prior studies frontotemporal lobar degeneration ftld sample size estimates detecting reduction annual rate roi atrophy varied substantially across groups per arm bvftd nfvppa svppa groups less estimated priori rois clinical measures variability location peak regions atrophy across individuals highest bvftd lowest svppa likely relating differences effect size conclusions findings suggest cross validated maps change improve sensitivity change ftld compared priori regions reliability maps differs considerably across syndromes future studies utilize maps design clinical trials try identify factors accounting variability patterns atrophy across individuals particularly bvftd
background hyperprolactinaemia found important cause infertility early seventies despite adequate release gonadotropic hormones presence hyperprolactinaemia ovulation fails occur suppression prolactin concentration normal led resumption normal menstrual pattern aim study find association serum prolactin infertility females reproductive age group materials methods prospective study fifty females reproductive age group irregular periods selected cases control group comprised fifty females reproductive age group regular periods parameters studied body mass index recent weight gain dysmenorrhoea dyspareunia hirsutism galactorrhoea serum prolactin estimation serum prolactin done using coat count prolactin irma immunoradiometric assay designed quantitative measurement prolactin serum statistical analysis done using pearson chi square test settings design prospective longitudinal study results cases bmi greater recent weight gain hirsutism dysmenorrhoea dyspareunia galactorrhoea cases show higher prolactin levels presented galactorrhoea conclusion serum prolactin definite role infertility
computational thinking problem solving method uses computer science techniques recently become mainstream many governments major internet companies promoting programming skills among children however little known programming affects aspects life beyond acquired programming skills regard paper summarizes work done school san diego san vicente madrid spain third quarter year conducted study four groups students grade measure extent use computer programming english classes interesting educational tool positive impact learning otucome students results show groups working programming activities improved groups using traditional resources moreover asked via surveys end study students felt coding positive influence learning english developing important skills teamwork learning learn
problem automatically constructing software component executed given environment satisfies goal recurrent software engineering controller synthesis field fits vision paper study controller synthesis partially observable lts models exploit link partially observable control non determinism show unlike fully observable lts kripke structure control problems setting existence solution depends interaction model controller environment identify two interaction models namely interface automata weak interface automata define appropriate control problems describe synthesis algorithms
although delirium shares clinical characteristics dementia lewy bodies dlb limited information regarding relationship delirium lewy body pathology report year old japanese woman episode delirium pathologically confirmed limbic type lewy body disease lbd although exhibited transient visual hallucinations delirium overt dementia developed core clinical features dlb died pneumonia age years autopsied case suggests delirium may one clinical phenotypes lbd prior onset dementia
since small inter electrode gap ieg high current density applied high heat generated redundant reaction product convection electrolyte leg becomes important factor stability electrochemical micro machining emm manufacturing engineering paper novel structure cathode used emm presented proper experimental parameters established simulated results hollow cathode much conductive flow designed fabricated basis non silicon surface micro machining technology experimental test showed improvement current stability consistent numerical simulations
biological data science emerging field facing multiple challenges hosting sharing computing interacting large data sets privacy regulations concerns risks leaking sensitive personal health genomic data add another layer complexity problem recent advances cryptography last five years yielded tool homomorphic encryption used encrypt data way storage outsourced untrusted cloud data computed meaningful way encrypted form without access decryption keys paper introduces homomorphic encryption bioinformatics community presents informal manual using simple encrypted arithmetic library seal made publicly available bioinformatic genomic research purposes
calcium oxide cao essential compound application catalyst effective chemisorbent toxic gases research sucrose capped cao nanoparticles cao nps prepared via simple eco friendly green synthesis method room temperature samples characterized ray diffraction xrd scanning electron microscopy sem transmission electron microscopy tem sem images showed calcium oxide nanoparticles cao nps nanoscale morphology tem images illustrated produced cao nanoparticle semicylindrical star shaped particles mean particle diameter length prepared cao nps tested antimicrobial activity overall studies indicated method could used production cao nps large scale cheap convenient way without using surfactant organic medium complicated instrumental procedure bioactive nanoparticles also inhibit biofilm formation may future applications cheap non toxic antimicrobial drug skin care products biomedical applications
study investigated neurobiological basis comorbidity autism spectrum disorder asd attention deficit hyperactivity disorder adhd compared children asd adhd adhd asd typically developing controls ctrl behavioural electrophysiological correlates gaze cue face processing measured effects asd adhd interaction edan erp marker orienting visual attention towards spatially cued location right hemisphere lateralised erp linked face processing identified atypical gaze cue face processing children asd adhd asd compared adhd ctrl groups findings indicate neurobiological basis presence comorbid asd symptoms adhd research using larger samples needed
endogenous social support systems young black men sex men ybmsm like surrogate families social networks considered crucial assets hiv prevention population yet extent social systems foster sexual health protections risks remains unclear examine networked patterns membership ballroom houses independent gay families black gay subcultures united states memberships related hiv protective risk traits members drawing population based sample ybmsm living chicago june july observe suite protective risk traits perform bivariate analyses assess associations member house family present analysis homophilous heterophilous mixing traits structures patterns house family affiliations among members bivariate analyses show members house family communities likely non members report protective traits like aware prep health coverage primary care doctor discouraging sex drug use among peers however members also likely engage use sex drugs respect traits inform specific house family affiliations results show members recent hiv test prep aware engaged exchange sex likely belong house family hiv positive individuals less likely cluster within houses families findings provide insights regarding strengths vulnerabilities house gay family communities inform culturally specific interventions build existing human social capital milieu elsevier ltd rights reserved
parry romberg syndrome rare disorder characterized progressive facial hemiatrophy skin subcutaneous tissue musculature bone cartilage often associated neurological symptoms trigeminal neuropathy paresthesia face migraine seizures paired ocular problems ipsilateral progressive body atrophy present young woman progressive facial hemiatrophy referred fdg pet hypometabolism observed left cingulate postcentral gyrus left cerebellum right basal ganglia hypometabolism may observed anatomical changes therefore facilitate early diagnosis
background youths universities high risk stis srh problems ethiopia however students perceive risk sti hiv infection though reports showed sexually active multiple sexual partners reported symptoms stis recognized threat posed srh problems study aimed assess srh experiences knowledge problems among university students ambo university ethiopia methods cross sectional study conducted ambo university main campus january february using mixed approach quantitative survey qualitative depth interview methods proportionate stratified sampling technique used select survey respondents purposive sampling employed identify depth interviewees quantitative data coded entered spss descriptively analyzed qualitative data categorically organized repeatedly reviewed thematically analyzed results mean age first sex mean number past months regular sexual partners recorded survey respondents perceived risk hiv almost survey respondents ever heard stis hiv aids knew modern contraceptives pills condoms despite awareness stis including hiv aids one fifth stis past one year although quantitative data showed unwanted pregnancy abortion existed campus minimally high rates unwanted pregnancy unsafe abortion reported qualitative data conclusions srh stis problems among students university although students knew stis sti infection rate past year quite high almost high percentage students reported sexual activity past year though reported minority students unwanted pregnancy unsafe abortion may also problem university thus needs launch program directed towards stis srh problems particularly among female students
intrusion response system irs one important components network security solution selects appropriate countermeasures handle intrusion alerts recently many techniques proposed designing automated irs however one big challenges intrusion response system considered literature lack standardization intrusion responses paper investigates model manage intrusion responses present multilevel response model provides high level view intrusion responses also propose foresight model estimate response cost considering ids alerts network dependencies attack damage response impact probability potential attacks furthermore data model defined represent exchange intrusion response messages standard format elsevier ltd rights reserved
objective psychotherapy clients know responses idk responses therapists questions typically considered non cooperating behaviors therapists actually handle behaviors remains unclear study therefore aims assess client therapist interactions following idk responses methods data collected dutch child adolescent mental healthcare service observing dialectical behavior therapy aimed adolescents severe emotional distress eighteen individual psychotherapy sessions involving two therapists six clients video recorded transcribed stand alone idk responses selected analyzed using conversation analysis results adolescents idk responses led varying actions therapists identified five categories continuations idk responses idk related continuation redoing question proposing candidate answer employing therapy specific techniques meta talk problematic nature idk response conclusions therapists treat idk responses non cooperative behavior part client idk responses also used starting point collaboratively enhance clients insights thoughts emotions behaviors practice implications idk responses therapists use variety continuation strategies varying therapeutic functions strategies embedded training therapists deal potentially non cooperative behavior elsevier ireland ltd rights reserved
background prior sailing injury studies small focused investigations large population based study examined mechanisms factors contributing sailboat related injuries deaths methods retrospective data analysis boating accident report database compiled coast guard performed database analyzed looking frequency events subgroup proportions determined cis calculated data used conjunction coast guard national recreational boating survey used estimate fatality rate results two hundred seventy one sailing related fatalities injuries reported fatality rate calculated deaths per million sailing person days weather hazardous waters listed primary contributing factors deaths deaths occurred falling overboard capsizing drowning common cause death victims wearing life jacket alcohol intoxication contributed deaths operator passenger preventable factors contributed injuries injuries nonmotorized sailboats result capsizing injuries motorized sailboats result collisions grounding conclusions calculated fatality rate similar alpine skiing falls overboard capsizing common fatal accidents operator inattention inexperience alcohol use common preventable factors contributing fatal nonfatal injury
inflammatory arthropathies share common tendency produce marked alterations skeletal remodelling architecture review focus seronegative spondyloarthopathies spa share common features respect tendency produce localized bone destruction sites articular peri articular inflammation however significant differences skeletal pathology conditions include unique involvement axial skeleton presence inflammation extra articular entheses spa also differences pattern bone formation repair associated articular peri articular inflammation review highlight molecular cellular processes involved pathogenesis skeletal pathology two forms inflammatory arthritis specific focus pathogenic mechanisms underlying differential patterns bone formation repair
background despite advances cancer diagnosis treatment significantly improved survival rates patients post treatment related health needs often adequately addressed current health services aim women wellness cancer program wwacp digitised multimodal lifestyle intervention enhance health related quality life women previously treated blood breast gynaecological cancers methods single blinded multi centre randomized controlled trial recruited total women within months completion chemotherapy primary adjuvant radiotherapy women randomly assigned either usual care intervention using computer generated permuted block randomisation intervention comprises evidence based interactive ibook journal web interface virtual health consultations experienced cancer nurse trained delivery wwacp week intervention focuses evidence based health education health promotion cancer diagnosis components drawn american cancer research institute world cancer research fund guidelines incorporating promotion physical activity good diet smoking cessation reduction alcohol intake plus strategies sleep stress management program based bandura social cognitive theoretical framework primary outcome health related quality life measured functional assessment cancer therapy general fact secondary outcomes menopausal symptoms assessed greene climacteric scale physical activity elicited physical activity questionnaire short form ipaq sleep measured pittsburgh sleep quality index habitual dietary intake monitored food frequency questionnaire ffq alcohol intake tobacco use measured australian health survey anthropometric measures including height weight waist hip ratio participants assessed measures baseline start intervention weeks completion intervention months determine level sustained behaviour change simultaneous cost effectiveness evaluation consider wwacp provides value money reported separately discussion women treated blood breast gynaecological cancers demonstrate increasingly good survival rates however experience residual health problems potentially modifiable behavioural lifestyle interventions wwacp
study considers intellectual capital based assumption capital possesses social aspects related emotional capacities emotional intelligence organization members literature review indicates relationship previously noted studied researchers agree emotional intelligence members organization affects organization intellectual capital based analysis relationship examined turkish business context data collected top managers affect intellectual capital businesses human beings emotional thus study emotional intelligence top managers opinions regarding intellectual capital businesses considered related interesting results factors emotional intelligence likely affect opinions regarding intellectual capital examined using multivariate model effect emotional intelligence revealed primarily three factors emotional intelligence empathy communication skill self awareness sociability affect participants opinions regarding intellectual capital businesses univariate models used evaluate effect emotional intelligence factor participants opinions regarding intellectual capital businesses empathy communication skills affect opinions quality human capital self awareness affects opinions organizational commitment workers sociability affect opinions information technology information sharing summary emotional intelligence affects opinions human capital quality information technology information sharing
british childhood cancer survivor study bccss provides first detailed investigation employment occupation undertaken large population based cohort previous studies limited design issues using small numbers survivors specific diagnoses involved limited assessment employment status occupational level bccss includes year survivors childhood cancer employment status occupational level ascertained questionnaire eligible survivors multivariate logistic regression used explore factors associated employment occupation compare survivors demographic peers general population employment status available survivors gender current age cancer type radiotherapy age diagnosis epilepsy consistently associated employed unable work managerial non manual occupations overall survivors less likely working expected deficit greatest irradiated cns neoplasm survivors compared general population survivors fivefold likely unable work due illness disability excess fold among cns neoplasm survivors treated radiotherapy overall survivors less likely managerial occupations expected however bone sarcoma survivors likely occupations expected also similarly non manual occupations survivors retinoblastoma neoplasm group also likely non manual occupations expected new employment job satisfaction contribute individual wellbeing performance modern society survivors childhood cancer however poor health significantly hinder ability work present study suggests using data british childhood cancer survivor study authors show compared general population survivors childhood cancer less likely working work activity limited particularly illness disability impacts greatest survivors central nervous system neoplasms treated radiotherapy findings help identify factors could targeted maximize survivors employment potential
consider problem estimating arbitrary dynamical parameter open quantum system input output formalism irreducible markov processes show limit large times system output state approximated quantum gaussian state whose mean proportional unknown parameter approximation holds locally neighbourhood size parameter space provides explicit expression asymptotic quantum fisher information terms markov generator furthermore show additive statistics counting homodyne measurements also satisfy local asymptotic normality compute corresponding classical fisher informations general theory illustrated examples two level system atom maser results contribute towards better understanding statistical probabilistic properties output process relevance quantum control engineering theory non equilibrium quantum open systems
deap dielectric electro active polymer new type smart material tubular actuator based deap material various potential applications fundamentally capacitive load high voltage bidirectional converter required provide power actuator bidirectional flyback based converter implemented parasitic elements serious influence operation converter especially high output voltage condition detailed behavior analysis performed considering impact critical parasitic parameters converter analyzed charging discharging processes low high output voltage operating occasions experimental waveforms validate analysis
background contact dermatitis defined inflammatory process affecting skin surface induced contact chemical physical biotic agents environment causes lesions skin mucosae semimucosae means allergic irritant pathogenic mechanisms among main triggers contact dermatitis pediatric age chemical physical agents cause irritant contact dermatitis icd sensitizers cause tissue damage allergic mechanism allergic contact dermatitis acd methods prospective multicenter observational study carried children affected contact dermatitis aged years enrolled pediatricians different italian provinces diagnosis contact dermatitis based pediatrician clinical evaluation data collected series simple multiple choice questions anonymously filled pediatricians results cases patients complete remission contact dermatitis cases worsening adverse events observed either effectiveness therapy rated effective parents pediatricians patients new therapy prescribed conclusions contact dermatitis heterogeneous inflammatory skin disease induced contact different kinds environmental agents cutaneous manifestations highly variable depend modality contact causative agent pathogenesis italian experience clinical approach contact dermatitis stresses need daily skin care different therapeutic strategies based diagnosis clinical severity parents children compliance first therapeutic measure implemented prevention removal causative agent use protective devices indeed preserving skin barrier function important goal priority treatment algorithms
widespread availability effective antiretroviral therapy art transformed hiv life limiting condition one near normal life expectancy hiv associated increased risk osteopenia osteoporosis people living hiv plhiv potentially experiencing conditions younger age hiv negative counterparts mechanisms driving bone disease hiv complex include increased prevalence traditional risk factors comorbid conditions hiv associated factors viral effects systemic inflammation art related factors one third plhiv united kingdom female increasing numbers women living hiv wlhiv reaching menopausal age oestrogen decline context elevated background risk poor bone health results wlhiv greater risk osteoporosis women without hiv european hiv guidelines therefore recommend routine screening postmenopausal wlhiv using frax clinical risk factors without bone mineral density scanning data support use calcium vitamin supplementation bisphosphonates treatment osteoporosis plhiv additionally patients confirmed osteoporosis may benefit switch art agent better bone safety profile however remains notable paucity data hiv menopause including impact hormone replacement therapy bone health wlhiv conclusion important clinicians aware postmenopausal wlhiv group particular risk bone disease require proactive screening advice preventative measures elsevier ireland ltd rights reserved
aim major depressive episode mde manifest different features discriminating different types mdes crucial proper treatment aim study propose new tool mde assessment bipolar disorder major depressive disorder mdd overcome limitations current rating scales proposed tool investigates clinical features different mdes gives qualitative information differentiating patients score different symptoms psychopathology severity achieve purpose authors used new methodology called formal psychological assessment fpa fpa allows creating relations items assessment tool set diagnostic criteria given clinical disorder application hand given capability analyze clinical features fpa appears useful way highlight differentiate inhibited agitated depressive symptoms method new tool contains items constructed clinical criteria dsm literature symptoms line fpa starting set items set clinical criteria boolean matrix built assigning item set clinical criteria participants include control group patients mde diagnosed mdd answered queds month participants performed test took depression anxiety stress scale analyze convergent divergent validity results scale showed adequate reliability validity hierarchical confirmatory factor analysis highlighted presence three sub factors affective somatic cognitive one high order factor depression conclusions new tool potentially able inform clinicians patients likely diagnostic configuration indeed clinical state patient consists subset items answered affirmatively along subset specific symptoms qualitative information fundamental clinical perspective allowing analysis treatment patient according symptoms effective way
studying problems journalists face important considering role journalists play reporting legitimizing problems confront society study explores journalists philippines young democracy unique media ecology consider important problem face drawing survey filipino journalists study found journalists philippines concerned low pay media violence information access professionalism younger journalists tend identify low pay important problem problem violence journalists salient reporters editors managers
appearance various trace emerging pollutants deteriorated water pollution events challenge existing analytical methods water treatment technologies past years technology termed surface plasmon resonance spr widely used detecting various types environmental analytes improving water treatment efficiency review spr principles surface modification methods summarized applications spr environmental detection heavy metals organic pollutants bacteria past decade illustrated addition use spr monitoring microbial attachment movement biofilm growth characterizing antifouling materials described spr widely used still considerably capacities exploited fully utilize spr investigation water pollution control process elsevier rights reserved
computer programming highly cognitive skill requires mastery many domains reality many learners able cope mental demands required learning programming thus leads rote learning memorization many reasons situation however one main reasons nature novice learners experience high cognitive load learning programming given fact novice learners lack well defined schema limitation working memory students could assimilate knowledge required learning many types learning supports like visualization provide reduce cognitive load expected visualization help reducing cognitive load expanding working memory however effect visualization learning clearly tangible two common methods used measure cognitive load namely physiological non physiological measures found based prior studies non physiological measure appropriate measuring cognitive load class room situation non physiological measures include nasa tlx rating scale also observed prior studies variation learning performance using visualization support among students homogenous group variation attributed level long term memory includes prior mathematical prior language skills demographics gender paper propose framework optimize instruction learners based background profile extent long term memory employ neural network optimize instruction suggesting best visualization tool learner paper also validates performance proposed tool study learners evaluate accuracy tool
goal study identify unique profiles readers sample year olds higher functioning autism spectrum disorders hfasd examine profiles relation asd symptom severity eighty one students assessed utilizing comprehensive reading battery included basic word reading language comprehension using latent profile analysis four empirically distinct profiles readers emerged next using autism diagnostic observation schedule second edition lord autism diagnostic observation schedule edn western psychological services torrance analyses conducted determine significant differences existed profiles result asd symptomatology findings demonstrate heterogeneous nature reading profiles students hfasd significant differences reading profiles asd symptom severity
background irritable bowel syndrome ibs causes chronic abdominal pain abnormal bowel movements etiology involves complicated interactions among visceral hypersensitivity disorders related bowel movements stress changes microbiota affect ibs pathophysiology investigated changes colorectal motility structure microbiota response stress due maternal separation corticotropin releasing hormone crh administration rats summary neonatal rats separated mothers daily postnatal day pnd pnd control group included rats age separated rats undisturbed weeks weeks age crh saline intravenously administered control groups two hours later number fecal pellets counted three hours crh saline administration rats sacrificed colorectal tissue samples cecal contents collected analyze fecal microbiota number fecal pellets significantly greater crh group stressors altered microbiota composition key messages among rats received crh increased colorectal motility stress due altered gut microbiota composition karger basel
stabilizing smallholder crop yields changing climatic conditions sub saharan africa require adaptation strategies focused soil water management impact studies climate change crop yields often ignore potential adaptation strategies rainwater harvesting rwh rwh bringing benefits agricultural systems today still unclear regions could increasingly benefit rwh changing climatic conditions employ continental scale modelling strategy using latest cmip data explicitly take account design factors rwh show valuable adaptation strategy climate change africa maize zea mays find rwh bridge yield gaps attributable water deficits current conditions future climatic conditions main growing season maize hence providing alternative irrigation scarce inaccessible groundwater resources rwh could increase maize yields average across africa bridging water deficits situ rwh strategies show great biophysical potential adaptation strategy climate change remain locally specific barriers adoption need addressed ensure successful implementation larger scale
hybrid electric thermal het following method proposed combined cooling heating power cchp system driven natural gas solar energy focusing supply matching domestic hot water space cooling heating electricity domestic hot water thermal demand class set met preferentially due immediateness timeliness space cooling heating class thermal demand matching condition discussed view comfort reliability detailed strategy methods summer winter conditions presented variable electric thermal ratio ratio thermal demand domestic hot water electric demand ratio thermal demand space cooling heating electric demand load conditions analyzed comparison het base following electric load following thermal load strategies discussed hotel applications criteria including primary energy consumption carbon dioxide emission operation cost exergy efficiency employed evaluate performances het strategy results indicate het achieve benefits base operation strategies elsevier ltd rights reserved
couched context experience economy research conceptualized transformations changes existential authenticity anxiety phenomenologically explored essence transformative tourist experience subsequent long term changes research uncovered nine chronologically ordered themes existentially oriented concerns prevalent found tourists reflect existential givens situ triggering episode initiated meaning making process existential anxiety felt post trip found motivate tourists resolve pertinent existential dilemmas initiate meaningful life changes participants sustained enhanced existential authenticity became sensitive existential anxiety lives thereafter
objective based mutations pax associated thyroid dysgenesis aim identify characterize pax mutations large cohort congenital hypothyroidism thyroid dysgenesis chinese population methods screened unrelated chinese patients thyroid dysgenesis pax mutations sequencing whole coding regions pax genomic dna isolated blood cell transfection assays using various vector constructs induced mutagenesis well electrophoretic mobility shift assays used investigate effects selected mutations transcribing binding activities pax promoters target genes thyroglobulin thyroperoxidase tpo results five pax mutations found yielding mutation prevalence selected two mutations critical paired domain pax generated mutants demonstrated unable bind specific sequence promoters tpo activate could bind tpo promoters normally activate promoter transcription tpo promoter transcription also demonstrated dominant negative role pax mutants impairing function wild type pax conclusion first time documented prevalence characterized function pax mutations chinese population study specifically demonstrated role novel mutations impairing function pax providing evidence genetic pax defects disease mechanism
summary retrospective observational study assessed year persistence compliance treatment route administration dosing frequency postmenopausal women initiating new osteoporosis therapy two year persistence compliance rates higher women receiving injectables compared oral agents purpose study extends previous studies limited year follow examining persistence osteoporosis therapies year period compares short long term trends persistence compliance among postmenopausal women commercial medicare supplemental insurance usa methods retrospective observational cohort study enrolled women years newly initiating osteoporosis therapy january december index date continuous enrollment months months index date persistence continuous therapy without day gap compliance index therapy evaluated years follow multivariable logistic regression used compare odds persistence compliance across treatment dosing regimens results study included patients mean standard deviation age years years follow persistence compliance higher patients treated injectable agents ranging excluding every month injection treated oral agents ranging additionally patients initiating oral bisphosphonates except risedronate daily raloxifene daily zoledronic acid annually significantly lower odds persistence compared denosumab every months conclusions patients initiating injectable therapies greater persistence compliance years initiating oral therapies patients initiating every month injection significantly higher persistence compared initiating frequently dosed daily weekly oral injectable agents
sexual minority stress experiences prejudice victimization etc peer substance use norms peers frequency use quantity consumed important correlates alcohol drug use sexual minority populations current study incorporates examining lgb individuals perceptions peers use alcohol drugs cope sexual minority stressor whether perceptions peer coping norms relate one coping motivated substance use response stressor three hundred seven sexual minority males females identified gay lesbian bisexual completed online survey approximately month following pulse nightclub shooting deadliest incident violence lgbt people history stressor experienced within lgb communities throughout results revealed lgb peers widely perceived likely coped alcohol drugs following pulse shooting however small proportions participants reported coping alcohol drugs multivariate models revealed even controlling factors including stress impact pulse shooting odds using alcohol cope event times greater among participants held perception lgb peers likely used alcohol cope relative share perception similarly odds using drugs cope event times greater among participants perceived lgb peers likely use drugs cope pulse compared importantly findings suggest personalized normative feedback designed correct perceptions peers coping motivated substance use may utility motivational component larger interventions seeking reduce lgbs substance use elsevier ltd rights reserved
thoracic extramedullary hematopoiesis emh rare manifestation patients myeloproliferative neoplasm year old woman long standing history polycythemia vera presented month history worsening dyspnea left sided wheezing chest computed tomography showed ill defined soft tissue mass encasing left main stem bronchus causing airway obstruction associated paratracheal paraesophageal lymphadenopathy endobronchial ultrasound guided fine needle aspiration soft tissue mass mediastinoscopy excisional biopsy paratracheal lymph node demonstrated emh increased myeloid blasts bone marrow biopsy confirmed postpolycythemic myelofibrosis consistent progression polycythemia vera myelofibrosis describe bronchoscopic management case emh presenting mediastinal mass mimicking malignancy
algorithm operational modal analysis time domain presented discrimination structural modes harmonic excitations spurious modes classification factor developed based construction damped signal noise ratio separates physical modes numerical ones harmonic excitations recognized high power indexes zero damping furthermore modal discrimination harmonic spectrum estimated frequency response function derived method updated time domain either short time sliding window recursive technique provide modal monitoring stationary non stationary process industrial application hydro electrical generator discussed identify machine frequencies operational working conditions
smith provided valuable review healthy cognitive aging addressing potential risk factors dementia well multiple mechanisms preventing dementia however missing discussion acknowledgment potential personality may play shaping trajectories cognitive aging current response provides brief review ever accruing evidence dispositional traits self efficacy beliefs predict trajectories cognitive aging well mechanisms produce trajectories including participants likelihood adhere intervention efforts reduce cognitive decline conclude presenting recommendations cognitive aging researchers practitioners integrate personality science work
non suicidal self injury nssi common multifaceted phenomenon among adolescents recent researchers shown number psychological psychiatric correlates implicated onset repetition nssi previous studies directly observe family interaction patterns clinical population paper quality family interactions observed using lausanne trilogue play procedure deepen specific interactive dimensions associated nssi adolescents results single case study showed lack positive emotional exchanges parenting style expressing hostility high level control difficulties triangulation method authors show better understanding role family interactions crucial could improve assessment treatment non suicidal self injurious behaviors research clinical implications discussed
rate heat released combustion diesel engines important many reasons including performance evaluation pollutant formation control combustion diesel engines generally divided three phases pre mixed diffusive mixed controlled late combustion objective paper estimate rate heat released fuel marine diesel engine order identify pre mixed diffusive phases using sampling importance resampling sir bayesian particle filter experimental pressure data obtained piezoelectric sensor installed research marine diesel engine man innovator used feed observation model bayesian approach evolution model pressure formulated terms set ordinary differential equations coming first law thermodynamics together random walk model unknown state variable proposed approach able identify pre mixed diffusive combustion phases different engine loads results compared simple inversion procedure showing good agreement combustion ignition delay also calculated showing variation engine load
robust conjugate direction search rcds method used optimize collimation system rapid cycling synchrotron rcs china spallation neutron source csns parameters secondary collimators optimized better performance collimation system improve efficiency optimization objective ring beam injection tracking orbit parallel module combined matlab parallel computing used run multiple orbit instances simultaneously study presents way find optimal parameter combination secondary collimators machine model preparation csns rcs commissioning
affordable reliable detection hepatitis virus hcv rna cornerstone management control infection affecting approximately global population however existing technologies expensive labor intensive time consuming posing significant limitations wide scale exploitation particularly economically deprived populations utilized unique optical physicochemical properties gold nanoparticles aunps develop novel assay platform shown rapid robust sensing quantifying unamplified hcv rna clinical samples assay based inducing aggregation citrate aunps decorated specific nucleic acid probe two types cationic aunps cysteamine ctab capped compared achieve maximum assay performance technology simple rapid cost effective quantitative sensitivity high specificity detection limit finally data suggest rna folding impact aggregation behavior functionalized aunps broader applications nucleic acid detection technologies
class nonlinear systems uncertainty fuzzy sliding mode control method based particle swarm algorithm combined strong robustness sliding mode control fuzzy control good approximation capability use quasi sliding mode control make system tracking error within given boundary layer within boundary layer replace switch control fuzzy control supervision function adopted control action smooth time join supervision control diffusion control input global stability control system condition sliding mode existence controller parameters optimized using particle swarm optimization ensure sliding mode control parameter perturbation external disturbance strong robustness reducing high frequency chattering system improved control performance controller simulation results show effective ness method
leukemic patients appendectomy must approached caution increased risk complications fungal appendicitis rare cases described literature particularly immunocompromised individuals infection fatal present pediatric patients acute myeloid leukemia developed appendicitis post chemotherapy neutropenic phase receiving antifungal prophylaxis fever first sign infection laparoscopic appendectomy performed without postoperative complications histologic examination culture analysis showed presence fungal elements systemic fungal infection also excluded risk increased immunocompromised children fungal appendicitis signs peritoneal irritation always obvious histopathologic demonstration fungal elements tissue reaction mandatory definitive diagnosis laparoscopic appendectomy considered gold standard procedure avoid fungal dissemination moreover laparoscopic surgery inherent mini invasive surgical advantages may improve overall survival without incurring significant complications
discuss touch based navigation visualizations combined monoscopic stereoscopic viewing environment identify set interaction modes workflow helps users transition modes improve interaction experience discussion analyze particular control display space mapping different reference frames stereoscopic monoscopic displays show mapping supports interactive data exploration may also lead conflicts stereoscopic monoscopic views due users movement space resolve problems synchronization support discussion present results exploratory observational evaluation domain experts fluid mechanics structural biology experts explored domain specific datasets using variations system embodies interaction modes workflows report interactions qualitative feedback system workflow
entity resolution important common data cleaning problem detecting data duplicate representations external entities merging single representations relatively recently declarative rules called matching dependencies mds proposed specifying similarity conditions attribute values database records merged work show process benefits integrating four components building classifier duplicate non duplicate record pairs built using machine learning techniques use mds supporting blocking phase record merging basis classifier results use declarative language logiql extended form datalog supported logicblox platform activities related data processing specification enforcement mds elsevier inc rights reserved
paeoniflorin major bioactive ingredient radix paeonia alba roots low toxicity shown neuroprotective effects vitro experiments suggested affords significant neuroprotective effect mpp induced damage apoptosis cells bcl bax caspase pathway objectives present study explore potential neuroprotective effect methyl phenyl tetrahydropyridine mptp treated mouse model parkinson disease results demonstrated treatment ameliorated behavioral deficits spontaneous motor activity latency fall rotarod test reduced dopaminergic cell loss induced mptp dose dependent manner vivo model addition found treatment protected dopaminergic neurons preventing mptp induced decreases striatal substantia nigra dopaminergic transporter dat tyrosine hydroxylase protein levels changing dopamine catabolism inhibiting dopamine turnover furthermore also associated regulation bcl bad ratio inhibition activation caspase caspase results showed promoted dopamine neuron survival vivo due mao inhibition pik akt signaling pathway may mediated protection mptp suggesting treatment might represent neuroprotective treatment elsevier ltd rights reserved
recent makeshift fuel choice renewable energy sources considered popular form kind environment friendly approaches less cost tariff policy natural fuel abundance inclusion power system promotes micro grid system optimize overall distribution fpga elaborated field programmable gate array proposes chances enhanced performance coveted flexibility design digital control conversely erudite convolution hardware description language hdl coding way translating hdl undesirable hurdle professional system designers design depicted letter instance system modeling fpga based digital control necessarily desired ability auto generate hdl codes architecture design uses dsp builder technology matlab simulink platform three phase full bridge gird tied inverter wind system three phase full bridge inverter grid connected wind system built demonstrates close correlation model necessary simulations results experimental analysis also highlighted different control techniques pwm control technique
psoriatic arthritis psa heterogeneous chronic inflammatory disease broad clinical spectrum variable course involve musculoskeletal structures well skin nails eyes gut management psa changed tremendously last decade thanks earlier diagnosis advancement pharmacological therapies wider application multidisciplinary approach commercialization tumor necrosis factor inhibitors adalimumab certolizumab pegol etanercept golimumab infliximab well interleukin ustekinumab secukinumab inhibitors representative revolution treatment psa evidence based strategies currently available guiding rheumatologist prescribe biological drugs several international national recommendation sets currently available aim help rheumatologists everyday clinical practice management psa patients treated biological therapy since specific biological agent demonstrated effective others drug choice made according available safety data presence extra articular manifestations patient preferences administration route drug price however future studies directly comparing different biological drugs assessing efficacy treatment strategies specific psa urgently needed
paper new circuit realizing floating lossless inductance simulator presented proposed simulator employs two copy current follower transconductance amplifiers cftas active elements single resistor single grounded capacitor workability proposed circuit verified spice simulations using tsmc level cmos process parameters second order voltage mode band pass filer
new methodology determine safety suspension bridge main cables proposed paper illustrated simulating failure corrosion deteriorated cable composed wires approach first use finite element model predict failure load account load recovery due friction broken wires simulate reduced strength cable three dimensional random field obtain cable failure load load increased gradually causing individual wires break according residual strength variability load transfer surrounding wires breakage individual wire affects stress state surrounding wires consequently load increased local damage spreads immediate vicinity eventually entire cable fails complexity problem critical failure load determined monte carlo simulation approach accounts uncertainty spatial variability residual strength individual wires probability distribution load drive suspension bridge cable failure reported investigated paper american society civil engineers
background mucormycosis highly lethal fungal infection especially immunocompromised individuals methods order review epidemiology diagnosis treatment mucormycosis renal transplant recipients searched publications mucormycosis cases renal transplant recipients pubmed database december results total cases renal transplant recipients included review cases male major underlying diseases diabetes mellitus rhinocerebral common site infection rhizopus species frequent fungus patients pathogen identified species level mortality rates disseminated mucormycosis graft renal higher infection sites overall survival patients received surgical debridement combined amphotericin posaconazole higher received antifungal therapy alone surgery alone without therapy overall survivals patients receiving posaconazole lipid amphoterincin higher receiving deoxycholate formulation conclusions mucormycosis severe infection renal transplant recipients surgical debridement combined antifungals especially liposomal amphotericin posaconazole significantly improve patient overall survival
modern biophysical methods isothermal titration calorimetry high purity inhibitor interest indispensable herein describe procedure synthesis purification functionalized phosphonamidate peptides able generate inhibitors metalloprotease thermolysin use biophysical experiments method utilizes allyl ester alloc protection strategy takes advantage fast effective solid phase extraction spe purification step applying strategy able synthesize series highly polar inhibitors featuring amino hydroxy functionalized side chains excellent purity
research field electronics group semiconductor structures attracted increasing attention past years exceptional combination unique electronic transport properties mature material know highly integrated silicon germanium technology holds promise enhancing state art electronics addition providing conduction channels bring conventional field effect transistors uttermost scaling limits physics group nanowires endows new device principles unconventional silicon germanium nanowire devices contenders beyond complementary metal oxide semiconductor cmos computing virtue distinct switching behavior higher expressive value review conveys reader systematic recapitulation analysis physics silicon germanium nanowires relevant cmos cmos like devices built silicon germanium nanowires including inversion mode junctionless steep slope quantum well reconfigurable transistors
recent years witnessed increasing emphasis human aspects software engineering research practices survey existing studies human aspects software engineering shows screen captured videos widely used record developers behavior study software engineering practices screen captured videos provide direct information software tools developers interact content access generate task human computer interaction hci data help researchers practitioners understand improve software engineering practices human perspective however extracting time series hci data screen captured task videos requires manual transcribing coding videos tedious error prone paper report formative study understand challenges manually transcribing screen captured videos time series hci data present computer vision based video scraping technique automatically extract time series hci data screen captured videos also present case study scvripper tool implements video scraping technique using hours task videos developers two development tasks case study evaluates runtime performance robustness tool also performs detailed quantitative analysis tool ability extract time series hci data screen captured task videos also study developer micro level behavior patterns software development quantitative analysis
integrated low voltage receiver digital satellite radio presented contains basic building blocks low noise amplifier lna baseband buffer two phase locked loops pll provide intermediate frequency local oscillator signals innovative solutions critical blocks lna buffer voltage controlled oscillator vco etc well new arrangements bias circuits adopted greatly increase circuit performance moreover regulated power supplies power capability also included receiver needs small number external components principally image filter surface acoustic ware saw channel filter achieves maximum gain noise figure internal regulators set ensure correct operation external power supply varying receiver integrated highperformance ghz silicon bipolar technology die size needs quiescent current
ankle sprains one common soft tissue injuries accounting nearly sports injuries large number procedures treatment reported literature largely good results ankle forms functional unit subtalar joint present new classification peritalar lateral instability two intents classification firstly classification demonstrates assessment treatment guideline many causes peritalar lateral instability second use classification research purposes cohorts patients accurately described efficacy different operations different groups properly assessed european foot ankle society published elsevier ltd rights reserved
autism spectrum disorder asd associated difficulty processing speech noisy background neural mechanisms underlie deficit mapped address question used magnetoencephalography compare cortical responses asd typically developing individuals passive mismatch paradigm repeated paradigm twice quiet background presence background noise focused evoked mismatch field mmf response temporal frontal cortical locations functional connectivity spectral specificity locations quiet condition found common neural sources mmf response groups right temporal gyrus inferior frontal gyrus ifg noise condition mmf response right ifg preserved group reduced relative quiet condition asd group mmf response right ifg also correlated severity asd moreover noise found significantly reduced normalized coherence deviant normalized standard asd relative beta band left temporal left inferior frontal sub regions however unnormalized coherence coherence deviant standard significantly increased asd relative multiple frequency bands findings suggest increased recruitment neural resources asd irrespective task difficulty alongside reduction top modulations usually mediated beta band needed mitigate impact noise auditory processing autism res international society autism research wiley periodicals inc autism res international society autism research wiley periodicals inc
background menorrhagia defined subjectively heavy menses lasting days objectively mean menstrual blood loss three consecutive menses occur due organic causes like fibroids polyps cervitis ovarian cysts adnexal masses uterine cancer systemic causes like hypothyroidism bleeding disorders pregnancy prolapse dysfunctional uterine bleeding body mass index may correlation menorrhagia aim objectives study carried western nepalese women assess causes menorrhagia report common symptoms associated assess correlation causes menorrhagia bmi material methods hospital based observational study carried january january volunteer women consulted department gynaecology obstetrics menorrhagia data collected via interview help questionnaire height weight patients recorded calculation bmi data analysed spss vesion mean standard deviation chi square test applied value considered statistically significant results study maximum patients age group years followed years whereas least number patients belonged age group years uterine fibroids common etiology menorrhagia seen patients maximum cases years age group minimum years age group dysfunctional uterine bleeding second common etiology cases years age group statistically significant association observed bmi etiology menorrhagia backache abdominal distension pain abdomen breast pain headache weakness pelvic pressure seven common symptoms experienced patients menorrhagia seven symptoms showed statistically significant association menorrhagia conclusion menorrhagia prevalent among age group years uterine fibroids dysfunctional uterine bleeding common etiologic factors seems clear association menorrhagia bmi significantly associated common symptoms like backache abdominal pain breast pain weakness abdominal distension pelvic pressure headache considerably affect quality life patients
research individual differences interpersonal accuracy ipa ability accurately judge others emotions intentions traits truthfulness social characteristics long tradition represents growing area interest psychology measuring ipa proved fruitful uncovering correlates skill however despite tradition considerable volume research efforts made look collectively nature tests involved assessing ipa leaving questions broader structure ipa unresolved ipa single skill clustering many discrete skills combination partially overlapping skills multi level meta analysis published unpublished participant samples participants analyzed correlations pairs ipa tests different ipa tests altogether overall correlation ipa tests corrected nesting correlations within studies administered two ipa tests reported several correlations participant sample test domain characteristics evaluated explain differences effect sizes general tests similar domains using similar methodologies highly correlated suggesting domains within individual differences cluster implications future research ipa measurement discussed
demonstrated previous publications consistent association dilated rectum overactive bladder children pioneering work topic first published sean regan described enema regimen ideally suited resolve megaretcum voiding compliants children experience grown population gained insight function dilated rectum role dysfunctional elimination syndrome methods required effective resolution review describe modified regan protocol developed treat patients resistant regan originally described regimen introduce concept rectal failure feel fully describes onset progression dysfunctional elimination syndrome
objective aim study evaluate levels gonadotropic sex steroidal hormones influence efficacy mirabegron treatment overactive bladder methods included female participants received treatment mirabegron daily provided blood sample hormone profiling treatment initiated serum hormone concentrations estradiol progesterone testosterone fsh tsh analyzed urinary distress inventory udi overactive bladder domain udioab short form pelvic floor impact questionnaire pfiq used assess subjective outcomes results significant overall improvements udi udioab pfiq baseline months follow respectively magnitude mean difference improvements similar pre postmenopausal women estrogen levels nonsignificantly lower participants experienced improvement udi udioab months follow compared clinically relevant differences hormone levels relation improvements udi udioab pfiq logistic regression analysis associations udioab outcomes age previous use anticholinergic drugs parity menopause local estrogen treatment conclusions estradiol gonadotropic hormones thyroid hormones testosterone levels influence clinical effects mirabegron women overactive bladder menopause status determinant mirabegron treatment
management athlete postconcussion syndrome pcs challenging nonspecificity pcs symptoms ongoing symptoms reflect prolonged concussion pathophysiology conditions migraine headaches depression anxiety chronic pain cervical injury visual dysfunction vestibular dysfunction combination paper focus physiological signs concussion help narrow differential diagnosis pcs athletes physiological effects exercise concussion especially important athletes athletes pcs exercise intolerance may result altered control cerebral blood flow systematic evaluation exercise tolerance combined physical examination neurologic visual cervical vestibular systems many cases identify one treatable postconcussion disorders
posttraumatic stress disorder ptsd mental disorder developing exposure traumatic events although psychotherapy reveals therapeutic effectiveness clinically sustainable cure still uncertain chinese herbal formulae reported work well clinically mental diseases asian countries safety mode action still unclear study investigated mechanisms chinese remedy free easy wanderer faew ptsd used reverse pharmacology approach combining clinical data search mechanisms ptsd subsequent vitro verification bioinformatics techniques follows analyzing microarray based transcriptome wide mrna expression profiling ptsd patients investigating effect faew antidepressant control drug fluoxetine transcription factor kappa using reporter cell assays western blotting performing molecular docking literature data mining based phytochemical constituents faew results suggest involvement inflammatory processes mediated kappa progression ptsd faew non cytotoxic vitro inhibited kappa activity protein expression faew anti inflammatory compounds paeoniflorin isoliquiritin isoliquiritin apioside ononin evaluated binding kappa reia molecular docking approach paeoniflorin albiflorin baicalin isoliquiritin liquiritin reported relieve depression vivo clinical trials might active ingredients faew ptsd
prospects roll forming analyzed requirements computer aided design cad roll forming equipment tools formulated cad system developed misis described
childhood maltreatment associated multiple adverse outcomes adulthood including poor mental health violence investigated direct indirect pathways childhood maltreatment adult violence perpetration explanatory role psychiatric morbidity analyses based population survey young men years great britain boost surveys black minority ethnic groups lower social grades respondents completed questionnaires measuring psychiatric diagnoses using standardized screening instruments including antisocial personality disorder aspd drug alcohol dependence psychosis maltreatment exposures included childhood physical abuse neglect witnessing domestic violence bullied adult violence outcomes included violence violence toward strangers intimate partners ipv victim injury minor violence witnessing domestic violence showed strongest risk adult violence aor direct pathway psychotic symptoms aspd partial mediators childhood physical abuse associated ipv aor mediated aspd alcohol dependence neglect associated violence toward strangers aor mediated aspd prevention violence adulthood following childhood physical abuse neglect requires treatment interventions associated alcohol dependence psychosis aspd however witnessing family violence childhood strongest direct effects pathway adult violence important implications primary prevention context prevention strategies prioritize focus early childhood exposure violence family home elsevier ltd rights reserved
background patients smoking status routinely collected general practitioners primary health care abundance read codes pertaining smoking including relating smoking cessation therapy prescription administration codes addition regularly employed smoking status codes large databases primary care data increasingly used epidemiological analysis smoking status important covariate many analyses however variable definition rarely documented literature methods secure anonymised information linkage sail databank repository national collection person based anonymised health socio economic administrative data wales exploration smoking status data sail databank carried explore range codes available could used identification different categories smokers smokers never smokers algorithm developed addresses inconsistencies changes smoking status recording across life course compared recorded smoking status recorded welsh health survey whs individual level however whs could regarded gold standard validation results individuals linked dataset missing data common records whs algorithm assigns smoker status never smokers detects smokers declared whs data distinguishing current smokers non smokers similarity whs data using nearest date comparison kappa temporal conflicts accounted similarity kappa showing importance addressing conflicts conclusions present algorithm identification patient smoking status using self reported data included sufficient details allow others replicate work thus increasing standards documentation within research area assessment smoking status routine data
objectives quantification work disability patients early rheumatoid arthritis receiving conventional dmards according treat target strategy methods retrospective cohort analysis patients received combination conventional dmards escalated achieve das esr remission completed annual work arthritis questionnaire random effect mixed modeling used assess associations average hours worked per week hwpw baseline prognostic factors hwpw compared matched population averages cox proportional hazards modeling employed evaluate associations permanent loss employment treatment response disease demographic factors results work data patients working baseline working point followed years range available analysis mean age years female seropositive rheumatoid factor anti cyclic citrullinated peptide anti ccp respectively men worked hours women highly significant association working hours lost increasing age hours female gender hours hwpw maintained study time comparable general population loss hwpw eular good responders months likely working years compared moderate response permanent loss employment baseline age strongly associated anti ccp positive participants conclusions treat target combination conventional dmard therapy maintains work capacity particularly good responders comparable general population improving treatment response moderate responders early disease may increase work retention
background aim limited data available regarding mortality inflammatory bowel disease non caucasian populations herein evaluated overall cause specific mortality hospital based cohort korean inflammatory bowel disease patients methods determined mortality crohn disease patients ulcerative colitis patients diagnosed standardized mortality ratios calculated several demographic phenotypic subgroups results mean year follow patients died crohn disease ulcerative colitis overall standardized mortality ratios confidence interval crohn disease ulcerative colitis crohn disease female sex ageyears ileocolonic disease diagnosis perianal fistula intestinal resection ever use corticosteroids associated higher mortality ulcerative colitis male sex age years diagnosis disease duration years proctitis diagnosis history colectomy associated lower mortality primary sclerosing cholangitis associated higher mortality crohn disease ulcerative colitis high mortality rates due nonmalignant gastrointestinal causes standardized mortality ratios respectively gastrointestinal malignancies standardized mortality ratios respectively observed cardiovascular mortality lower ulcerative colitis standardized mortality ratio conclusions overall mortality tended higher crohn disease patients general population slightly lower ulcerative colitis patients general population
fixed speed wind turbines low efficiency compared variable speed fixed pitch wind turbines latter required optimize power output performance without aerodynamic controls wind turbine system operated points wind rotor curve electrical generator curve coincide order obtain maximum power output wind turbine generator system necessary drive wind rotor optimal rotor speed particular wind speed maximum power point tracking mppt controller used purpose fixed pitch variable speed wind turbines wind rotor parameters fixed restoring torque generator needs adjusted maintain optimum rotor speed particular wind speed optimum power output turbulent wind environment control variable speed fixed pitch wind turbine systems continuously operate maximum power points becomes difficult due fluctuation wind speeds therefore special emphasis given operating maximum aerodynamic power points wind rotor study wind speed forecasting techniques considered predictive optimum control system wind turbines reduce response time mppt controller
persistent challenge field psychopathology best explain mental disorders organize clinical symptoms diagnoses meta structural approaches clarified fundamental problems made substantial gains using covariance structures organize nature clinical symptom patterns remaining task specify connections patterns across behavioral cognitive neural mechanisms together meta structural approaches national institute mental health nimh research domain criteria rdoc offer means parse connections comment included articles special section psychopathology meta structure argue core dimensions psychopathology identified meta structural approaches advance rdoc initiative rdoc framework turn strengthen structural approaches providing organizational scaffold elucidate relations behavioral cognitive neural mechanisms relate dimensions human suffering dysfunction
paper deals characterization construction rotating brushless exciter intended synchronous generator excitation purposes traditionally exciters used pre exciters synchronous generator excitations systems order reduce number components increase step time response system exciter designed outer pole machine permanent magnets stator armature windings rotor exciter constructed electrically mechanically fitted house synchronous generator test setup finite element model exciter validated load measurements voltages magnetic flux densities exciter characterized unsaturated saturated parameters
objective paper report published papers posttraumatic stress symptoms ptss posttraumatic stress disorders ptsd traumas experienced homeless zimbabwean refugees living south africa general purpose papers explore pre postmigration difficulties predicts posttraumatic stress symptoms disorder understand gender differences ptss ptsd reports using quantitative qualitative approaches finally understand nature abuses perpetrators sex perpetrators method focused group discussions fgd structured depth interviews data collected randomly selected homeless zimbabwean refugees polokwane limpopo province south africa age participants ranged years years mean age years participants assessed demographic variables pre post migration difficulties checklists general health questionnaire ghq ptsd checklist civilian version pcl results results paper indicated majority participants significantly traumatized pre postmigration traumas contributed ptss ptsd qualitative study paper overwhelmingly shared similar experiences could temporally framed pre mid postmigration many challenging sociocultural structural institutional factors experienced seen across migration stages paper results structural equation model sem showed none paths pre postmigration stress poor mental health ptsd significant men whereas women path poor mental health ptsd beta significant finally fourth paper showed rape sexual harassment common abuses perpetrators mainly single male border police officers conclusion zimbabwean refugees found constitute particularly vulnerable group experienced cumulative traumas therefore reported ptss ptsd poor mental health findings discussed line practical implications refugees south africa xenophobic feelings rise
paper proposes predictive control algorithm includes conduction mode detection power factor correction pfc converter pfc converters line current usually distorted characteristics proportional integral current controller improve quality current current controller requires additional circuits algorithms however optimal duty cycle determined estimating next state current continuous conduction mode discontinuous conduction mode proposed predictive control method fast dynamic response accuracy compared current control method moreover proposed algorithm detect conduction mode without additional circuitry mode detection algorithm using characteristic optimal duty cycle calculated predictive control advantages proposed algorithm improve quality line current pfc converters verify proposed method performing experiment using pfc converter
background substance use mental health robustly associated smoking poor cessation outcomes often examined combination menthol cigarette smoking also associated lower quit rates study identified classes black white menthol non menthol cigarette smokers based demographics alcohol drug tobacco use behaviors methods using screening data two studies latent class analysis lca conducted classify menthol non menthol cigarette smokers demographic characteristics heavy smoking alcohol drug use desire quit smoking tobacco product use use psychotropic medication results three latent classes identified differentiated smokers substance use menthol cigarette smoking tobacco use behavior one class consisted primarily young adults used wide array tobacco products reported highest prevalence drug use showed lowest desire quit smoking cigarettes next months class comprised primarily black male menthol smokers used cigarillos addition cigarettes displayed moderate drug use third class categorized primarily older cigarette smokers engaged little tobacco use drug use likely self report prescribed psychotropic medication conclusions lca allowed identification distinct classes smokers based factors related poor cessation outcomes including menthol use previously examined combination interventions target specific groups smokers rather take one size fits approach
background dake humi traditional japanese bamboo foot stimulator consisting half pipe shaped step made bamboo used stimulate foot stepping commonly used promote general health among elderly japan however efficacy reported scientific literature study performed investigate role dake humi focusing lower urinary tract symptoms luts constipation hypersensitivity cold methods participants luts constipation enrolled study dake humi used twice day days days starting dake humi use international prostate symptom score ipss quality life qol score overactive bladder symptom score oabss measured evaluate efficacy dake humi luts evaluate objective efficacy dake humi luts frequency volume chart fvc plotted luts patients days visual analogue scale vas used evaluate efficacy dake humi constipation vas constipation vas participants constipation results total participants enrolled study twenty one participants luts constipation participants ipss especially storage subscore qol score oabss decreased significantly use dake humi use dake humi increased maximal bladder capacity resulting significant decrease urinary frequency determined fvc accordance results vas constipation vas constipation significantly relieved dake humi use conclusion results prospective pilot study indicated dake humi safe therapeutic efficacy cases luts constipation possibility using dake humi physical neuromodulation therapy shown management luts constipation
electromagnetism scattering characteristics stealth target base bistatic radar design study anti stealth technology bistatic radar radar cross section rcs calculated measured true contrail simulation conclusion accordant theory valuable data provided theoretical bases design anti stealth radar systems
multi agent based simulation artificial stock market asm important method behavioural finance social network asm influence coordination decision making intelligent agents improve performance asm evolving social networks distributed computing environment computational load balancing inter nodes communication considered jointly paper proposes scheduling algorithm called lbmic partition agents onto different computing nodes keeping degree load imbalance lower given threshold minimized inter nodes communication agents lbmic models scheduling graph partitioning problem uses multi level graph partitioning algorithm achieve efficient scheduling network evolves lbmic refines partitioning migrating parts agents experiments indicate lbmic efficiently improve performance communication intensive asms initial partitioning refining partitioning
aim ecosystem based management ebm maintain ecosystem healthy productive resilient condition implementation policies management measures although cross sectoral planning may led planning competent authority sector competent authority implement necessary management measures within operations achieve ebm goals objectives suggest scientific impediments ebm longer significant implement ebm operationally instead consider approaching ebm within current policy cycle approaches would provide necessary policymaking process step operationalize ebm addition enabling facilitating collaboration exchange understanding promoted ebm policymaking processes also require policy implemented programs measures procedures controls expected outcomes carry effect policy objective view moving ebm planning objective setting operational implementation management problem solving issues instead scientific one
recent mountain pine beetle dendroctonus ponderosae hopkins outbreaks unprecedented effects lodgepole pine pinus contorta var latifolia western north america used data forest inventory plots analyze stand conditions regulate lodgepole pine mortality across wide range stand structure species composition fraser experimental forest colorado usa forest inventory data combined landsat enhanced thematic mapper plus etm imagery boosted regression trees modeling map outbreak severity proportion basal area killed outbreak severity map evaluated training pseudo rmse independent test plots pseudo rmse map used compare pine mortality regenerating clearcuts mature stands would problematic otherwise since regenerating clearcuts underrepresented forest inventory data mortality spanned stand basal area proportional abundance pine surveyed stands outbreak mortality highest larger diameter trees however contrary earlier outbreaks beetles also attacked younger stands pine mortality lower stands regenerating clearcut harvests conducted mature stands closely related topographic factors stand age clearcut size mortality highest southerly aspects lower elevation sites favorable lodgepole pine best predictors mapping outbreak severity change normalized difference moisture index pre end outbreak imagery end outbreak etm band better understanding mortality patterns relative forest management inform management planning assessment influence bark beetle outbreaks ecosystem processes elsevier rights reserved
wildfires significant effects human populations economically environmentally terms general well smoke pollution particular either prescribed burns uncontrolled wildfires significant health impacts estimates suggest smoke dispersion fire events may affect health one three residents united states leading increased incidence respiratory illnesses asthma pulmonary disease scarcity measurements particulate matter responsible public health issues makes addressing problem smoke dispersion challenging especially fires occur remote regions crowdsourced data become essential component addressing societal problems disaster relief traffic congestion utility monitoring air quality impacts wildfire events unexplored study assessed user generated social media content used complementary source data measuring particulate pollution wildfire smoke found frequency daily tweets within area significant predictor levels beyond daily geographic variation results suggest social media valuable tool measurement air quality impacts wildfire events particularly absence data physical monitoring stations also analysis semantic content people tweets provided insight socio psychological dimensions fire smoke impact people residing working otherwise engaging affected areas
tropoelastin dominates physical performance human elastic tissue assembled make elastin tropoelastin increasingly appreciated protein monomer defined solution shape comprising modular bridged regions specialize elasticity cell attachment collectively participate macromolecular assembly modular multifaceted molecule exploited enhance physical performance biological presentation engineered constructs augment repair human tissues tissues include skin vasculature emphasize growing knowledge tropoelastin powerfully adapted add value pre existing devices like stents novel multi featured biological implants elsevier rights reserved
students mathematics difficulties math word problem solving especially challenging purpose study examine effects problem solving strategy bar model drawing mathematical problem solving skills students study extended previous research suggested schematic based instruction sbi cognitive strategy instruction csi delivered within explicit instruction framework effective teaching various math skills related word problem solving multiple baseline design replicated across groups used evaluate effects intervention bar model drawing math problem solving performance students student achievement measured terms increased correct use cognitive strategies overall accuracy math word problem solving results showed bar modeling drawing effective strategy increasing elementary students accuracy solving math word problems ability use cognitive strategies solve problems
work focuses subthreshold design ultra low voltage low power operational amplifiers well defined procedure systematic design subthreshold operational amplifiers amps introduced design two stage miller compensated amplifier fabricated complementary metal oxide semiconductor process presented amp operates transistors subthreshold region achieves gain gain bandwidth product khz dissipating active area chip approximate experimental results demonstrate well designed subthreshold amps attractive solution implement sub energy efficient applications modern portable electronic systems comparative analysis low voltage low power amp designs available literature highlights subthreshold amps designed according proposed design procedure achieve better trade among speed power load capacitance copyright john wiley sons ltd
people living hiv aids plwha united states disproportionately high rates food insecurity general population associated cognitive impairment among older adults may exacerbate hiv associated neurocognitive disorders current study assessed effects hiv infection neuropsychological performance hiv positive hiv negative adults main effects minimal interactive effects revealed related deficits speed information processing learning memory motor function overall cognitive impairment hiv positive group hiv negative group interactive effects remained controlling relevant sociodemographic characteristics although bidirectional associations ruled cross sectional study results suggest may contribute cognitive impairment among hiv positive adults given high rates socioeconomic disadvantage among plwha addressing part routine clinical care may warranted
background antitumor necrosis factor anti tnf medications known highly efficacious persons moderate severe inflammatory bowel disease ibd paucity data population based sources elucidate persistence medications general population ibd discontinuation anti tnf therapy marker lack effectiveness intolerance patient physician practice preferences methods identified persons ibd manitoba dispensed infliximab ifx adalimumab ada subjects followed longitudinally assess rates completion anti tnf induction duration continued use intraclass substitution dose adjustments cox proportional hazards models used test demographic clinical factors associated anti tnf therapy discontinuation results overall persons ibd prescribed anti tnf drug crohn disease ifx ada ulcerative colitis ifx ada approximately four fifths persons starting anti tnf therapy completed induction years persistence rates original anti tnf approximately respectively immunomodulator use time anti tnf dispensation associated decreased likelihood anti tnf discontinuation crohn disease ulcerative colitis ada users crohn disease reached maintenance phase higher risk discontinuation ifx users hazard ratio confidence interval conclusions approximately two fifths anti tnf users discontinue use within year initiation three fifths discontinued years concomitant therapy modest effect discontinuation rates
mentalization research focuses different aspects topic highlighting individual differences mentalizing proposing programs intervention children adults increase ability thought mind project tim project provides training targeted adults teachers parents increase mentalization consequently obtain mentalization improvement children present research aimed explore first time ever potential training teachers based tim project regarding enhancement mentalizing adult would interacted teacher children reason two teachers similar meta cognitive meta emotional skills classes randomly assigned training control condition first case teacher participated training implementation promotion mentalizing everyday school teaching strategies second case teacher participated control activity similar training scheduling methods without promoting implementation mentalization conditions two meetings lasting beginning school year two supervisions school year conducted children tested tasks assessing several aspects mentalization second third order false belief understanding strange stories reading mind eyes mentalizing task teacher participate tim control training beginning end school year results showed although measured components mentalization progressed time tim project training group significantly improved third order false belief understanding changed greater way compared control group two three components mentalizing task evidences promising idea creation mentalizing community promotes mentalization abilities members
background inside transobturator tape tension free vaginal tape obturator tvto currently one effective popular procedures surgical treatment female stress urinary incontinence sui however data reporting long term outcomes lacking objective assess efficacy safety tvt implantation treatment female pure sui design setting participants multicenter prospective study conducted five tertiary referral centers three countries consecutive women urodynamically proven pure sui treated tvt included patients mixed incontinence anatomic evidence pelvic organ prolapse excluded intervention tvt implantation outcome measurements statistical analysis data regarding subjective outcomes international consultation incontinence questionnaire short form patient global impression improvement patient satisfaction scores objective cure stress test rates adverse events collected follow univariable analysis performed investigate outcomes results limitations one hundred sixty eight women tvt implantation follow patients available evaluation find significant change surgical outcomes time surgery patients declared cured similarly evaluation patients objectively cured significant deterioration objective cure rates observed time history failure previous anti incontinence procedures hazard ratio predictor recurrence sui onset novo overactive bladder reported patients follow late complications reported conclusions results study showed tvt highly effective safe option treatment sui patient summary long term follow tension free vaginal tape obturator highly effective safe treatment stress urinary incontinence european association urology published elsevier rights reserved
background vaccination coverage tetanus toxoid reduced diphtheria toxoid acellular pertussis tdap vaccine pregnancy immediately postpartum low limited data exist rigorously evaluated interventions increase maternal vaccination including tdap tailored messaging based elaboration likelihood model elm framework successful improving uptake public health interventions evaluated effect two elm based vaccine educational interventions tdap vaccination among pregnant african american women group women tend lower vaccine uptake compared groups methods conducted prospective randomized controlled trial pilot test two interventions affective messaging video cognitive messaging ibook among pregnant african american women recruited routine prenatal care visits measured tdap vaccination perinatal period pregnancy immediately postpartum reasons non vaccination intention receive tdap next pregnancy results among enrolled women completed follow tdap vaccination perinatal period control group ibook group risk ratio control group video group baseline follow women reported intention receive tdap next pregnancy improved three groups among unvaccinated women common reason reported non vaccination lack recommendation tdap woman physician conclusions education interventions provide targeted information pregnant women interactive manner may useful improve tdap vaccination perinatal period however larger studies including multiple racial ethnic groups needed evaluate robustness findings elsevier ltd rights reserved
primary myelofibrosis pmf rare chronic bcr abl negative myeloproliferative neoplasm characterized progressive bone marrow fibrosis inefficient hematopoiesis shortened survival clinical manifestations pmf include splenomegaly consequent extramedullary hematopoiesis pancytopenias array potentially debilitating constitutional symptoms diagnosis based bone marrow morphology clinical criteria mutations jak mpl calr exon indel genes found approximately patients whereas remaining called triple negatives activation jak stat pathway results overproduction abnormal megakaryocytes leading bone marrow fibrosis mutations might accompanied mutations asxl commonly used prognostication scoring pmf based international prognostic scoring system subsequently developed dynamic international prognostic scoring system plus employs clinical well cytogenetic variables pmf calr mutation associated superior survival asxl inferior outcome patients triple negative pmf higher incidence leukemic transformation lower overall survival compared calr jak mutant patients impact genetic lesions survival independent current prognostic scoring systems observations indicate driver passenger mutations define distinct disease entities within pmf accounting relevant clinical decision making also considered designing clinical trials karger basel
paper presents approach modular contract based verification discrete time multi rate simulink models verification approach uses translation simulink models sequential programs verified using traditional software verification techniques automatic generation proof obligations needed verification correctness respect contracts automatic proofs also discussed furthermore paper provides detailed discussions correctness step verification process verification approach demonstrated case study involving control software prevention pressure peaks hydraulics systems
study objective examine prevalence circadian misalignment clinically diagnosed delayed sleep phase disorder dspd compare mood daytime functioning without circadian basis disorder methods one hundred eighty two dspd patients aged years engaged regular employment school underwent sleep wake monitoring home followed sleep laboratory visit assessment salivary dim light melatonin onset dlmo based dlmo assessments patients classified two groups circadian dspd defined dlmo occurring desired bedtime dbt non circadian dspd defined dlmo occurring dbt results one hundred three patients classified circadian dspd non circadian dspd dlmo occurred hours later circadian dspd compared non circadian dspd moderate severe depressive symptoms beck depression inventory prevalent circadian dspd non circadian dspd relative non circadian dspd patients circadian dspd patients times increased odds least mild depressive symptoms group differences found daytime sleepiness function dspd symptoms rated clinicians severe circadian dspd conclusions almost half patients clinically diagnosed dspd show misalignment circadian pacemaker dbt suggesting reported difficulties initiating sleep dbt unlikely explained mis timing circadian rhythm sleep propensity circadian misalignment dspd associated increased depressive symptoms dspd symptom severity
exosomes naturally occurring extracellular vesicles released mammalian cells body fluids exosomes known key mediators cell cell communication facilitate transfer genetic biochemical information distant cells structurally exosomes composed lipids proteins also several types rnas enable vesicles serve important disease biomarkers moreover exosomes emerged novel drug gene delivery tools owing multiple advantages conventional delivery systems recently increasing attention focused exosomes delivery drugs including therapeutic recombinant proteins various target tissues exosomes also promising vehicles delivery micrornas small interfering rnas usually hampered rapid degradation rnas well inefficient tissue specificity currently available delivery strategies review highlights recent accomplishments trends use exosomes delivery drugs therapeutic rna molecules
current study aimed address impact serum type diabetes patients angiogenic properties human bone marrow mesenchymal stem cells relationship autophagy signaling human primary stem cells enriched incubated serum diabetic normal subjects days compared data control group diabetic serum found induce higher cellular death rate apoptotic changes also showed diabetic condition significantly abolished angiogenesis tube formation matrigel substrate decreased cell chemotaxis response sdf inhibited endothelial differentiation rate western blotting showed autophagic status high levels beclin increase lcii ratio vivo matrigel plug assay revealed supernatant conditioned media prepared cells exposed diabetic serum caused marked reduction recruitment cadherin sma positive cells days subcutaneous injection pcr expression array analysis confirmed overexpression autophagy apoptosis genes cultured cells response diabetic condition using bioinformatic analysis noted crosstalk network angiogenesis autophagy signaling could potently modulate angiogenesis interaction downstream insulin receptor upstream androgen receptor corroborating data diabetic serum led abnormal regulation angiogenic response data demonstrate diabetic serum decreased human mesenchymal stem cell angiogenic properties directly angiogenesis pathways induction autophagy signaling cell biochem wiley periodicals inc
composite liquid metal marble made metal droplet coated water film proposed impact dynamics phenomenon disclosed encapsulating liquid metal water droplets fabricated liquid marble successfully avoided oxygenized metal fluid thus significantly improved many physical capabilities surface tension modification shape control striking behaviors composite liquid metal marbles substrate room temperature experimentally investigated high speed imaging way disclosed marbles could disintegrate merge even rebound impacting substrate unlike existing dynamic fluidic behaviors liquid marble metal droplet mechanisms lying behind features preliminarily interpreted fundamental finding raised profound multiphase fluid mechanics understanding complex liquid composite also critical variety practical applications liquid metal jet cooling inkjet printed electronics printing metal particle fabrication etc
although single center cross sectional studies suggested modest impact liver donation donor psychological well studies assessed outcomes prospectively among large cohort conducted one largest prospective multicenter studies psychological outcomes living liver donors within adult adult living donor liver transplantation cohort study aall consortium total eligible donors interviewed least donation donation using validated measures found living liver donors reported low rates major depressive alcohol abuse anxiety syndromes given assessment first years donation donors reported impaired mental well various time points identified significant predictors donors perceptions better people experiencing psychological growth following donation including age sex relationship recipient ambivalence motivation regarding donation feeling donation would make life worthwhile results highlight need close psychosocial monitoring donors whose recipients died donors experienced guilt concerns responsibility careful screening targeted data driven follow hold promise optimizing psychological outcomes following procedure potentially vulnerable donors prospective study living liver donors across nine transplant centers shows low rates major depressive alcohol abuse anxiety syndromes though donors whose recipients die may benefit close psychosocial monitoring
background aims high levels serum uric acid sua associated increased mortality risk general population contrasting results available people diabetes aim study investigate association functional form sua cause mortality patients type diabetes mellitus tdm methods studied three cohorts patients tdm gargano mortality study foggia mortality study pisa mortality study cause mortality rate end point study results reliable relationship sua levels cause mortality rate quadratic model well approximated sua tertiles tertiles higher risk mortality compared tertile hazard ratio confidence interval respectively pseudo sample created real pooled sample best relationship sua cause mortality rate quadratic tree based recursive partitioning regression tree analysis two subgroups increased risk mortality identified namely sua levels sua levels compared patients intermediate sua levels thus providing evidence shaped relationship sua levels mortality rate conclusions sua linearly associated cause mortality rate patients tdm clinical public health purposes association shaped published elsevier ireland ltd
objective social anxiety common condition associated social communication difficulties typically developing young people well autism spectrum disorder asd whether difficulties place children risk developing unclear using longitudinal design present study aimed disentangle relationship symptoms difficulties using population based sample children avon longitudinal study parents children alspac method parent reported data difficulties symptoms collected ages years cross lagged panel model used investigate longitudinal stability directional relationship latent difficulties constructs time results difficulties associated greater symptoms ages earlier difficulties predicted asmall significant amount variance later symptoms reverse relationship difficulties observed relationship difficulties strongest age years sex differences observed conclusion evidence suggests difficulties may important risk factor development findings suggest potential usefulness incorporating social skills training alongside effective interventions prevent alleviate symptoms childhood
background ocular allergy growing public health problem greatly impacts day day life sufferers families aspects activities daily living schooling professional social life affected hence increased awareness knowledge ocular allergies detection treatment paramount study assess level knowledge awareness ocular allergy among undergraduate students public universities ghana methods descriptive cross sectional survey conducted among students three selected public universities ghana respondent completed questionnaire questions concerning awareness knowledge ocular allergy results students aware ocular allergy students level knowledge ocular allergy generally low majority students source information ocular allergy media internet statistical significant association among awareness ocular allergy sources information programme study conclusion level awareness among university students generally low students programmes study influenced knowledge ocular allergy public health measures recommended help educate students prevention control ocular allergy well complications associated condition
paper proposes new method controlling cross flow water turbine cfwt based generation systems fixed pitch power regulation method consists directly controlling electrical generator power imposed dispatcher without employing inner rotational speed control loop proposed control approach represents base operation framework output power rotational speed limitations start stopping entire operating range cut water flow speed permanent magnet synchronous generator used paper system operated low rotational speed values called hydrodynamic stall region mechanical hydrodynamic stresses lower given region corresponds unstable dynamic behavior power regulation relies upon inner loop rotational speed stabilization consequently innermost electrical machine current control loop fed reference two components namely driving stabilization currents embodied control laws output power rotational speed limitation sequences experimentally validated real time simulator cfwt based generation systems
present development world economic compression cost energy grown dramatically pollution global warming become enormously weighty problems many researchers focused reduce energy consumption emission rising demand energy saving environmental protection world range hybrid system one better solution result paper predominantly investigates energy recuperation system hybrid excavator novel energy recuperation system proposed verified simulation results done amesim software also competed conventional system system power storage component electrical battery combined hybrid actuator using electric motor electrical generator energy convention component cementation controlling strategy used control hybrid excavator emulate mandates conferred driver optimize energy saving procedure generator battery also proposed measures improve energy recuperation efficiency proposed system presented series simulation performed clarify performance efficiency respect conventional one parameters taken real system
ageism generate conflict harm well paper integrates aging stereotypes interaction model intergroup contact theory predict communicative elements mediate effect intergenerational contact warmth competence stereotypes older adults group students randomly assigned imagine conversation older adult one six experimentally manipulated contact conditions competent incompetent older woman sociable unsociable older woman moral immoral older woman participants stereotypes older adults affected characteristics communication partner effect mediated specific communication behaviors imagined participant two three trait dimensions perceptions competence overaccommodation key mediator perceptions sociability key mediator humorous communication mediators represent expansion understand outcomes intergroup contact also communicative mechanisms occurs
objectives study aimed examine whether occupational physical activity different ages contribute parkinson disease risk large population based case control study denmark methods identified patients danish national hospital register recruited gender year birth matched controls danish central population register occupational leisure time determined job exposure matrix based occupational history self reported leisure time information results association found occupational alone men higher leisure time hours week strenuous activities young adulthood years associated lower risk adjusted odds ratio oradj confidence interval men engaged high occupational high leisure time young adulthood lowest risk oradj among women inverse associations found occupation age highest lowest oradj strenuous leisure time age oradj clear pattern seen leisure occupational combined conclusions observed gender specific inverse associations occupational leisure time risk however preclude reverse causation especially older ages since long prodromal stage might lead reduction years motor symptom onset diagnosis
article presents results tests influence thermo mechanical treatment parameters temperature cooling conditions mechanical properties microstructure steel mnb indicated cold heading process rolling conducted simulation continuous finishing train arrangement four rolling stands laboratory faculty metallurgy materials engineering vsb ostrava results presented tests applied optimization rolling process rolling mill type morgan equipped system regulated cooling stelmor achieved results steel mnb useful optimization heat plastic treatment order achieve products good mechanical properties
study carried estimate actual evapotranspiration humid area perak state malaysia water evaporation cycle deeply influences climate natural resources human living aspects images terra aqua platforms moderate resolution imaging spectroradiometer modis sensor used estimation employing surface energy balance algorithm land sebal model part accuracy assessment process situ measurements soil temperature reference recorded time satellite overpass order enhance accuracy generated maps modis images subjected sub pixel analysis assigning weights different land surface cover urban agriculture multi surface areas reflections weighting process achieved integrating pure pixels respective site specific land cover enhanced sebal model estimated exhibited good correlation situ measured penman montieth values aqua terra platforms respectively however correlation non enhanced maps resulted values aqua terra platforms respectively hence results study revealed feasibility employing sub pixel analysis method accurate estimation large areas
mechanical manufacturing engineering mme organizations commonly recognize value knowledge resources yet fail effectively exploit assets knowledge management solutions provide means appropriate exploitation resources published implementations mme contexts compared wealth solutions published sectors paper demonstrates methodology creation solution space based review analysis characterization sources including examples problems within companies different industry sectors example solution set used identify appropriate tools solve related problems many mme contexts
high thermally thermo oxidatively stable poly phenylene carborane ppb synthesized via catalyzed polymerization bis aryl chloride monomer containing carborane polymer soluble thf nmp room temperature thus allowing molecular weight spectroscopic analysis number average molecular weight determined nmr spectroscopy mol crystalline character ppb verified xrd analysis polymer exhibited excellent thermal thermo oxidative stability weight loss temperature degrees degrees nitrogen air respectively high char yields obtained degrees nitrogen air respectively additionally ppb proven excellent sing source precursor boron carbide carbon ceramic materials high ceramic yields range according xrd analysis boron carbide crystallization ppb occurred degrees published elsevier ltd
cigarette smoke known interact tamoxifen metabolizing enzymes transporters potentially affect treatment outcome nitrosomethylamino pyridyl butanol nnal important metabolite methylnitro samino pyridyl butanone nnk frequently used biomarker assess human smoke exposure order study potential pharmacokinetic interaction cigarette smoke tamoxifen rats uplc method simultaneous determination nnal tamoxifen along metabolites rat plasma developed validated analytes extracted methanol separated hss column gradient elution mobile phase consisting acetonitrile water lower limits quantitation ranged precisions showed rsd accuracy range mean analyte recoveries ranged method successfully applied study effects cigarette smoke condensate csc nnk benzo pyrene pre treatment pharmacokinetics tamoxifen metabolites rats significant effects csc nnk benzo pyrene observed pharmacokinetics tamoxifen metabolites also found plasma nnal levels statistically significant correlated plasma hydroxy tamoxifen endoxifen
association chronic myeloid leukemia cml myeloproliferative neoplasms mpns particular mutation janus kinase jak gene uncommon cases reported literature present study case year old man cml persistent thrombocytosis reported patient achieved complete cytogenetic response major molecular response imatinib patient presented jak mutation bone marrow morphology consistent essential thrombocythemia patient treated imatinib hydroxyurea control platelet count maintains complete imatinib upon years follow although rare association breakpoint cluster region abelson rearrangement jak mutation investigated patients mpn since genetic anomalies may present diagnosis may emerge treatment require different therapeutic approaches
two dimensional analytical numerical solutions determining geometric dimensions stresses geotextile tubes reviewed conventional one dimensional approximation average drop height consolidated height geotextile tubes also reviewed study densification modeling fill material based areal strain analysis introduced leshchinky approximation method considers vertical movement densifying material analysis areal strain method offers alternative analysis approach wherein vertical lateral movements densifying fill material considered geotextile tube assumed resting rigid horizontal foundation analyses filling densified stages treats internal material liquid order apply normal pressure tube parametric cases densification geotextile tube fill presented results show degree tube height reduction decreases density slurry fill increased large scale tests conducted composite geotextile tubes made outer woven inner non woven polyester pet material tubes long theoretical diameters respectively validity solution densification analysis demonstrated comparing numerical results field test agreement numerical results field measurement data fairly acceptable elsevier ltd rights reserved
green building research rising years rational mode human beings nature china traditional architecture contains rich experience ecological design examined green design strategies neo vernacular also becoming important pay real attention article demonstrates integrated ecosystem approach design process neo vernacular architecture called xijie hope providing certain reference help similar study authors published elsevier ltd
background evidence increasingly indicates poor sleep quality major public health concern household food insecurity hfi disproportionately affects latinos novel risk factor poor sleep quality psychological distress may potential mechanism hfi affects sleep quality sleep food insecurity distress linked type diabetes mellitus objectives examined relations hfi psychological distress sleep quality tested whether psychological distress mediates relation hfi sleep people diabetes mellitus methods latinos type diabetes mellitus completed baseline assessments calms community health workers assisting latinos manage stress diabetes stress management intervention trial completed household food security survey measures depressive symptoms personal health questionnaire depression scale phq anxiety symptoms patient reported outcomes measurement information system promis short diabetes distress problem areas diabetes questionnaire paid sleep quality pittsburgh sleep quality index psqi psychological distress operationalized phq promis short paid scales used unadjusted adjusted indirect effect tests bias corrected bootstrapped cls samples test relations variables potential mediation results mean age women food insecure experiencing hfi associated greater psychological distress worse sleep quality depressive symptoms adjusted anxiety symptoms adjusted diabetes mellitus distress adjusted mediated relation hfi worse sleep quality without adjustment age education income marital status employment status conclusions household food insecurity common potent household stressor associated suboptimal sleep quality psychological distress efforts improve food security decrease psychological distress may yield improved sleep high risk population calms stress management trial registered clinicaltrials gov nct
tri generation plants important role near future residential sector heating cooling demands come play throughout year depending building location characteristics enclosure use thermal loads demands different article analyses compares combined cooling heating power cchp system tested laboratory single household located spain cooling capacity obtained using reversible heat pump compressor driven directly gas engine internal combustion engine ice technology tests carried work bench three different operating speeds variable speed model developed trnsys simulation environment operating strategy following thermal load ftl micro cchp system modeled experimental data validated dynamically simulated analyze performance different climatic zones defined spanish codigo tecnico edificacion cte study reveals micro cchp system suitable mild weathers summer season
linear mixed effects model based full likelihood one methods available model longitudinal data subject left censoring however full likelihood approach complicated algebraically large dimension numeric computations maximum likelihood estimation computationally prohibitive data heavily censored moreover mixed models complexity computation increases dimension random effects model increases propose method based pseudo likelihood simplifies computational complexities allows wide class multivariate models used many different data structures including settings level censoring high motivation work comes need joint model assess joint effect pro inflammatory anti inflammatory biomarker data day mortality status simultaneously accounting longitudinal left censoring correlation markers analysis genetic inflammatory markers sepsis study conducted university pittsburgh two markers interleukin interleukin naturally correlated shared similar biological pathways left censored limited sensitivity assays considered determine higher levels markers associated increased risk death accounting left censoring assumed correlation copyright john wiley sons ltd
systematic method proposed approach complete fault coverage catastrophic faults analog circuits proposed method fault propagation graph first created circuit netlist standard graph theory techniques employed identify minimal set observation points mop monitoring points complete fault coverage achieved potential catastrophic faults circuit detected theoretically developed method valuable increasingly critical quality requirements modern applications lack existing methods achieve sub ppm test escapes state art widely used benchmark circuit cmos operational amplifier utilized demonstrate validate method simulation results show catastrophic faults detected monitoring identified mop
methodology presented obtaining processing data web science wos bibliometric purposes statistical software used tool creating functions facilitate bibliometric work addition relational database created enhances data management generation bibliometric indicators
open ended piles tubular piles beams used foundations offshore nearshore construction pile installation load test estimate bearing capacity open ended piles necessary due offshore conditions high bearing capacity installed piles static load test normally feasible therefore dynamic load tests carried wave propagation due dynamic impact pile head measured methods estimate bearing capacity measured signal dynamic tests derived solid pile profiles questionable whether evaluation techniques applicable open ended piles hence influence various important system parameters well differences static dynamic load tests open ended piles investigated paper
phytoene colorless carotenoid increasing economic potential skin care limited availability red yeast xanthophyllomyces dendrorhous previously used production platform carotenoids engineered prototype yield carotene phytoene accumulated prevention metabolization desaturation carotenoid pathway first step phytoene desaturase gene crtl disrupted insertion hygromycin resistance gene resulting transformants heterozygote intact inactivated crtl upon cultivation orange transformants selection pressure white colonies homozygote disrupted crtl obtained contrast reddish wild type orange transformants contained colored carotenoids together phytoene whereas homozygote transformant synthesized phytoene exclusively targeted mutagenesis approach first tested wild type applied high yield carotenoid synthesizing dendrorhous mutant second step precursor supply phytoene synthesis enhanced expression genes hmgr crte crtyb encode limiting enzymes pathway combination engineering approaches resulted phytoene producing dendrorhous strain accumulated shaking cultures finally experimental small scale fermenter studies demonstrated continuous growth strain fermentation stable phytoene production without selection pressure fermenter culture contained highest phytoene content ever reached organism elsevier rights reserved
objectives scope evaluations indigenous parenting programs designed improve child psychosocial outcomes methods electronic databases gray literature indigenous websites journals reference lists searched search restricted high income countries history colonialism results sixteen studies describing evaluations programs found controlled studies united states australia targeting child social emotional behavioral mental health outcomes delivered groups parents program content focused often child development learning child behavior management parent child interactions studies reported improvements child parent outcomes though majority used self report measures noncontrolled studies conclusions scoping review provides first known map evaluations programs targeting parents indigenous children rigorous evaluations effectiveness rigorous systematic review needed evaluate strength extent findings
purpose incarcerated women around globe predominantly reproductive age women pregnant many want sexually active avoid pregnancy upon release yet women regular method contraception providing contraceptive services women custody benefits individual public health goals reducing unintended pregnancy policy briefing reviews evidence unmet need family planning correctional setting policy implications expanding services paper aims discuss issues design methodology approach authors describe four model programs usa established contraceptive services site highlighting practical steps facilities implement findings correctional facilities health administrators providers advocates legislators advance policies counsel women family planning make range contraceptive methods available release remaining sensitive potential pressure women may feel use birth control unique environment practical implications family planning services incarcerated women benefits individuals facilities community social implications policies enable correctional facilities provide comprehensive family planning incarcerated women including reproductive life goals counseling contraceptive method provision promote equity access critical reproductive health services also provide broad scale population level benefits preventing unintended pregnancy enabling counseling healthy pregnancies group women often limited access services originality value policy briefing highlights area health care prisons jails gets little attention research policy circles family planning services incarcerated women addition reviewing importance services population authors also highlight model family planning programs correctional facilities provide actionable insights administrators providers
purpose aim study find overall prevalence rates major forms abuse among adolescents kingdom saudi arabia differences prevalence age gender living arrangement methods cross sectional study conducted secondary high schools five main regions kingdom saudi arabia multistage stratified sampling technique sample adolescents years identified invited participate ispcan child abuse screening tool child used data collection previous year occurrence violence exposure psychological physical sexual abuse neglect assessed results nearly adolescents years age cared biological parents annual prevalence various forms abuse year assessment ranged lowest rate sexual abuse highest psychological abuse significantly greater rates forms abuse exposure found participants lived mother father versus even greater rates lived biological parent step parent rates violence exposure psychological abuse neglect significantly greater girls rate sexual abuse greater boys conclusions attention given effect adolescent maltreatment particularly among girls addition sexual abuse prevention programme targeted among boys
background depression common health condition affecting third patients attending primary care care people depression provided adequate recognition depression critical step path effective care particularly low income countries part programme improving mental healthcare prime project supporting implementation integrated mental healthcare primary care evaluated level recognition depression clinicians working primary care rural ethiopia prior service training hypothesised detection rate depression detection would affected gender education severity depression methods cross sectional survey eight health centres serving population people validated version item patient health questionnaire phq administered indicator probable depression addition primary care clinicians completed clinician encounter form participants consecutive primary care attendees aged years results total participants assessed primary care clinicians diagnosed attendees depression phq prevalence depression cut score ten received diagnosis depression primary care clinicians attendees higher phq scores suicidality significantly likely receive diagnosis depression clinicians women participants higher educational attainment likely diagnosed depression albeit non significantly cases diagnosed depression clinicians presented psychological symptoms conclusion although based gold standard diagnosis cases phq depression undetected failure recognition depression may pose serious threat scale mental healthcare low income countries addressing threat urgent priority requires better understanding nature depression presentation rural low income primary care settings
personality research term blind spot luft ingham denotes personality characteristics people aware consensually attributed others investigation revealed evidence normative blind spot characterizing average target distinctive blind spots characterizing specific targets latter finding implies average person aware ways uniquely consensually perceived people respective effect size substantial compared effects field person perception consensus future research investigate people may benefit knowledge others others elsevier inc rights reserved
oxidative stress involved many neurological diseases including alzheimer disease punicalagin hydrolysable polyphenol derived punica granatum potent antioxidant study neuroprotective effect glutamate induced oxidative stress evaluated mouse hippocampal cell line treatment protected cells glutamate induced cell death concentration dependent manner potentially attenuated glutamate induced intracellular reactive oxygen species ros restored mitochondrial membrane depolarization metabolic alterations glutamate induced oxidative stress protective effect evaluated hplc profiling methods multivariate statistical analyses alterations ten metabolites identified including amino acids aspartic acid asparagine threonine anserine cysteine tryptophan lysine well fatty acids palmitic acid stearic acid palmitoleic acid metabolic pathway analysis revealed involvement multiple affected pathways cysteine methionine metabolism tryptophan metabolism alanine aspartate glutamate fatty acid oxidation results clearly demonstrate promising therapeutic agent oxidative stress associated diseases
present investigation bovine ovary prenatal development studied using immunohistochemistry laserassisted microdissection lam major aim study evaluate protein expression pattern intermediate filaments distinguish protein alpha beta protein isoforms prenatal follicle differentiation subsequently correlating germ cell marker expression development specific expression pattern different keratins well vimentin detected prenatal bovine ovary specific expression found developmental stages surface epithelium germ cell cord somatic cells follicle cells keratins vimentin stage specific expression pattern different cell populations prenatal ovaries additionally results represent new data expression pattern germ cell markers bovine ovary prenatal development alpha beta protein localized oocyte cytoplasm different follicle stages alpha staining could observed granulosa cells furthermore isolation characteristic ovary cell populations using lam specific confirmation genes interest krt krt alpha beta oct ddx could obtained pcr single cell groups developing bovine ovary karger basel
many college students exhibit unhealthy eating behaviors consuming large quantities high fat foods fruits vegetables perceived stress linked daily dietary choices among college students however work conducted among predominantly white female populations role perceived stress management moderating relationship unclear study investigated relationship perceived stress dietary choices among diverse sample male female college freshmen assessed whether perceived ability manage stress moderated relationship students large public university completed online survey assessed past week consumption various foods beverages soda fast food fruits vegetables well perceived stress ability manage stress hierarchical linear regression examined association perceived stress past week dietary choices moderating effect perceived ability manage stress controlling demographic variables perceived stress positively associated past week soda coffee energy drink salty snack frozen food fast food consumption perceived stress management moderated relationship stress sweet snack consumption individuals reported low ability manage stress consumed greater amounts findings indicate greater stress associated poor dietary choices among college freshmen relationship stress sweet snack consumption exacerbated among reported low ability manage stress may important college nutrition education programs focus relationship stress diet promote effective stress management techniques elsevier ltd rights reserved
objective study determine heterosis inbreeding depression genetics yield quality resistance early blight tomato consequently twenty inter specific crosses tomato developed crossing five susceptible cultivars four wild resistant accessions tested field glasshouse conditions early blight resistance biochemical responses also critically studied parents hybrids crosses showed moderately susceptible reaction except five crosses solarium habrochaites biochemically wild parents exhibited better results susceptible parents hybrids showed moderate reaction early blight resistance high level phenol found resistant parents hybrids among crosses made manifested resistance capacity low heterosis high inbreeding depression disease yield associated traits crosses expressed high heterosis low inbreeding depression indicated better yield capacity crosses made habrochaites segregated resistant susceptible mendelian ratio indicated monogenic dominant additive gene effects remaining crosses showed resistant intermediate susceptible genetic ratio indicated heterozygous nature crosses mediated multiple genes qtls fact utilized future tomato breeding program developing resistant varieties disease published elsevier
although various treatments used weight loss date obese people rarely safe effective treatment options therefore antiobesity effects several natural compounds actively investigated study conducted investigate antiadipogenic effects monascus ruber fermented fagopyrum esculentum red yeast buckwheat ryb cells assessed intracellular lipid content adipocyte differentiation oil red staining expression genes proteins associated adipocyte differentiation reverse transcription polymerase chain reaction western blotting cells ryb dose dependently inhibited cell differentiation concentrations without cytotoxic effects also suppressed expression adipogenic transcription factors including peroxisome proliferator activated receptor gamma ccaat enhancer binding protein adipocytespecific genes adipocyte fatty acid binding protein fatty acid synthase leptin preadipocyte differentiation adipocytes furthermore ryb reduced cyclin dependent kinase cyclin expression increased expression thus causing cell cycle arrest phase collectively results suggest ryb may effective nutraceutical weight loss indicated ability suppress adipogenesis specific gene expression cause cell cycle arrest interphase
vascular supply human bladder derived mainly superior inferior vesical arteries latter directly connected internal iliac artery aging associated impairment blood vessel function changes may occur vasculature molecular cellular functional level pelvic arterial insufficiency may play important role development bladder dysfunctions detrusor overactivity overactive bladder syndrome chronic ischemia related bladder dysfunction may progress bladder underactivity would desirable treat lower urinary tract symptoms luts induced chronic ischemia also progression morphological bladder changes studies experimental models rabbits rats shown pelvic arterial insufficiency may result significant bladder ischemia reduced bladder wall oxygen tension turn lead oxidative stress associated upregulation oxidative stress sensitive genes increased muscarinic receptor activity ultrastructural damage neurodegeneration phosphodiesterase type pde inhibitor tadalafil alpha adrenoceptor blocker silodosin beta agonist mirabegron free radical scavenger melatonin exerted protecting effect urodynamic parameters functional morphological changes bladder demonstrable vitro since agents tested used clinically relieving luts results animal models seem translational value may relevance designing clinical studies demonstrate drugs may prevent progression ischemia related functional morphological bladder changes
problem based learning pbl often seen nothing approach difficult apply traditional curricula based traditional lectured courses exercise lab sessions aalborg university since creation practiced pbl subjects including computer science software engineering following model become known aalborg model following strategic decision aalborg model reshaped first report software engineering program old aalborg model analyze programme wrt competence levels according bloom taxonomy compare expected skills competencies engineer passing general software engineering year program additional years experience defined ieee software engineering body knowledge swebok abran also compare graduate software engineering curriculum guidelines graduate degree programmes software engineering gswe pyster describe new curriculum draw preliminary conclusions based analyzing curriculum according bloom taxonomy results running program years new program structured compliant bologna process thus presents activities multipla european credit transfer system points envision elements program could used traditional curricula especially easy programs also complying bologna process
many studies date implied biases metacognition memory called metamemory contribute development maintenance positive symptoms schizophrenia however study exists longitudinally followed patients experiencing positive symptoms present article therefore reviews cross sectional studies retrospective metamemory abilities participants within different stages schizophrenia spectrum disorder heterogeneous symptom severities creating pseudo longitudinal overview summarized deterioration abilities correlating psychosis development inferred reviewed publications indicate metamemory biases already found patients riskmental state psychosis arms patients first episode psychosis fep seem severely impaired arms patients similarly affected compared chronic patients contribution biases pathogenesis psychosis discussed giving consideration relations cognitive metacognitive functions neurochemical processes neural correlates hypothesized biases represent early cognitive markers beginning persisting psychotic state early treatment program could help patients ameliorate general course illness even prevent risk transition psychosis
article describes origins power system connection field reliability shown stability whole system possibilities could lead final brake article analyzes cases history led collapse power system points cases could occur future
purpose mortality salient factor capital sentencing purpose paper examine role death plays jurors decisions sentencing severely mentally ill defendant subject possible discrimination capital trial status design methodology approach current experiment measured venire jurors mental illness dangerousness beliefs experimentally manipulated type mortality salience dual focused participants contemplated mortality exposed trial related death references trial focused exposed death references type defendant severely mentally ill neutral accused capital offense findings mock jurors perceived mental illness important mitigating factor dual self focused mortality dfm salience induced whereas participants exposed trial related death references considered mental illness aggravating factor sentencing likely evidence stereotype adherence toward defendant practical implications implications authors findings problematic current legal system majority capital sentencing jurors exposed trial related death references individuals trial focused mortality condition findings suggest jurors likely engage discriminatory stereotypes consider fair process making sentencing decisions research also suggests mortality salience may able increase jurors attention concerns trial scenario even negative mental illness stereotypes present originality value research builds existing terror management theory offers nuanced perspective focusing one death affect jurors reliance stereotypes lead inappropriate decisions mortality salience lead decisions based upon procedural fairness stereotypes mortality salience present
theme world digestive health day diet gut health world gastroenterology organization thereby wishes raise awareness relationship eat gastrointestinal symptoms world digestive health day wdhd celebrated year may brief review article behalf new zealand society gastroenterology highlight recent developments highly active area research special emphasis gastrointestinal disorders
extremely hot humid environments common numerous occupational settings construction work tough physically demanding difficulty exacerbated hot humid weather tropical subtropical regions established heat stress models different environmental indicators study aims ascertain environmental indicator would better able predict effects heat stress construction workers field studies conducted summer hong kong july august physiological work related environmental personal parameters measured validate established heat stress models basis sets synchronized meteorological physiological data collected construction workers two different construction sites mean absolute percentage error mape theil inequality coefficient used assess models terms predictive accuracy wet bulb globe temperature wbgt found highest validity mape theil inequality coefficient practicality predicting effects heat stress construction workers specific heat stress guidelines formulated based wbgt protect health safety site personnel working hot humid weather conditions
fully integrated tuner digital satellite audio radio applications using second zero dual conversion architecture realized sige bicmos technology autonomous agc channel decoder controlled agc used optimize signal path gain wide range input signal levels single pll drives mixers resulting smaller die area lower power dissipation converting signal baseband reduces tuner power due lower required adc sampling frequency resolution providing digital baseband output allows implementation channel decode standard digital cmos process reducing overall receiver cost sdars tuner performance includes noise figure image rejection dbm input sensitivity dbm iip min gain agc range current consumption supply die area
paper low power consumption regulator proposed ultra high frequency uhf rfid tag stable output voltage sub blocks regulator supplied elementary stage output rectifier proposed operational amplifier opa circuit works class biased adaptive biasing circuit besides proposed regulator used bandgap reference bgr circuit sampling circuit based cmos technology low power consumption output regulator ripple values lir psrr efficiency regulator respectively considering omega load power consumption regulator calculated operating frequency mhz simulated tsmc cmos technology elsevier gmbh rights reserved
paper presents newly developed method analysis flow around open rotors characterised hubs general shape exact implicit solution axysimmetric inviscid incompressible flow represented superposition infinite ring vortices properly arranged along hub surface rotor wake solution made explicit semi analytical iterative procedure proposed semi analytical approach deal hubs arbitrary shape quite general rotor load distributions method strongly couples flow induced rotor hub moreover contraction divergence rotation wake fully taken account results semi analytical method also compared obtained widely diffused actuator disk model based computational fluid dynamics cfd techniques finally comparison advanced methods relying cfd approach method characterised extremely reduced computational cost computer code freely available contacting authors
objective implant metal minimally invasive repair nuss procedure pectus excavatum often causes metal allergy postoperative infection titania chitosan anti allergy anti inflammatory effects study conducted evaluate effects titania chitosan nuss repair patients stainless steel methods total patients recruited randomly assigned two groups one group received nuss repair using stainless steel group another group using stainless steel coated titania chitosan sstc group infection rate metal allergy haller index measured presence overt infection evaluated measuring serum levels erythrocyte sedimentation rate esr reactive protein crp results mean month nuss repair postoperative infection occurred cases cases sstc groups respectively hand cases case suffered bar allergy implant metal sstc groups respectively needing reoperation sstc groups respectively surgery month serum levels esr crp higher group sstc group non infected patients comparatively serum levels esr crp significantly higher group sstc group infected patients conclusion stainless steel coated titania chitosan provides safer effective material nuss repair reducing metal allergies infection rates reoperation rates
paper examines central place list associated concept identifier within scaffolding contemporary institutional order terms deliberately chosen make strange help unpack constitutive capacity information systems information technology within contemporary organizations draw upon substantial body work john searle help understand place lists identifiers constitution institutional order enable ground discussion potentiality problematic associated lists describe number significant instances list making situated particularly around use identifiers refer people places products theorization developed allows better explain significance imbued within lists identifiers key part play form ing institutional order also hint role symbolic artifacts play within breakdowns institutional order
signal flow graph method analogue implementation wavelet transform using switched current circuits proposed wavelet transform synthesized bank switched current bandpass filters whose impulse responses mother wavelet dilations facilitate implementation arbitrary wavelet function proposed approach employs signal flow graph methodology design wavelet filter first derivative gaussian wavelet used example paper illustrate design details simulation results show feasibility proposed method
fluidized bed coal combustion fbc clean coal combustion environmentally friendly process low emission nox atmosphere however fly ash fbc process suitable utilization due high sulfate low glassy phase contents fbc fly ash ground reduce pore increase specific surface area use source material geopolymer fbc fly ash geopolymers different sodium silicate sodium hydroxide mass ratios studied characterized using ray diffraction xrd scanning electron microscopy energy dispersive ray spectroscopy sem edx fourier transform infrared spectroscopic ftir techniques compressive strength materials also tested test results indicated ratio significant effect morphology strength geopolymer low ratio gave low strength geopolymer large amount calcium hydroxide high ratio mixes increased water glass content gave dense homogeneous composites presence high amount calcium resulted formation calcium silicate products coexisted sodium aluminosilicate products society powder technology japan published elsevier society powder technology japan rights reserved
background objectives squill drimia maritima stearn important medicinal plant used medicinal purposes cardiovascular diseases asthma since ancient times bufadienolides main compounds plant responsible reported adverse effects order reduce adverse effects different methods like boiling vinegar applied traditional practitioners present study acute oral toxicity cytotoxic effects proscillaridin content antibacterial properties methanol vinegar extracts squill white variety compared exploring efficacy traditional processing method methods different doses extracts administered oral gavage rats analyze acute oral toxicity cytotoxicity caco niht cell lines antibacterial activity staphylococcus aureus staphylococcus epidermidis bacillus subtilis pseudomonas aeruginosa klebsiella pneumoniae escherichia coli investigated using mtt assay conventional agar dilution method respectively proscillaridin content evaluated extracts vinager methanol validated high performance liquid chromatography method results vivo research death observed effect occurred animals received extracts results showed extracts exhibited cytotoxic effects experimented cell lines proscillaridin detected methanol extract significant antibacterial effect detected methanol extract conclusion according results present study processing squill vinegar according traditional experiences reduce possible side effects bufadienolids
genes certain conditions make carriers altruistic identified altruism selfishness shown heritable man raises possibility genetic polymorphisms altruism selfishness exist man animals characterize conditions genetic polymorphisms may occur show dominant recessive alleles positions stable equilibria depend benefit recipient cost altruist diploid altruists helping half full sibs haplodiploid altruists helping sisters stable polymorphisms always occur close hamilton threshold position stable equilibrium moves away increases cost paid altruist increasing divergence hamilton threshold alleles selfishness reach frequencies around evaluate quantitative estimates field studies light predictions values fall regions genetic polymorphisms expected nevertheless interesting see genes altruism discovered whether accompanied alternate alleles selfishness
approximately patients borderline personality disorder bpd show nonsuicidal self injurious behavior nssi cutting frequently applied method one nssi functions reduce aversive tension previous studies found tension reducing effect painful tissue injury incision still unclear whether effect based effect tissue injury effect pain experience aim study determine whether tissue injury leads stronger stress reduction sole pain stimulus patients bpd stress induction bpd patients healthy controls hcs received either incision non tissue injuring mechanical nociceptive stimulus blade typically perceived painful nonnociceptive tactile sham stimulus blunt end scalpel participants unaware procedure applied stress assessment subjective objective parameters measured immediate response stimulus application found greater stress reduction painful stimuli incision blade bpd patients difference stress decrease tissue injuring incision non tissue injuring pain stimulus blade compared hcs incision blade followed greater immediate decrease arousal bpd patients findings confirm among bpd patients nociceptive input leads stress reduction contrast impact tissue damage stress reduction relatively small addition results suggest painful stimuli lead greater stress reduction bpd patients compared hcs
dipyrone metamizole powerful drug widely used analgesic antipyretic however safety use lactation potential impact offspring well established study aimed determine effect maternal dipyrone treatment lactation offspring development emotional behavior dam maternal behavior hence postnatal day pnd drinking water drinking water containing dipyrone doses day offered lactating mothers pnd thereafter mice provided regular drinking water pnd litters culled pups males females maternal behavior evaluated pnd pnd evaluated locomotor activity open field reflex parameters physical development offspring evaluated lactation pnd analysis ultrasonic vocalization usv performed animals reached adolescence evaluated performance open field elevated plus maze epm marble burying data demonstrated maternal dipyrone treatment lactation altered maternal behavior onset physical neurodevelopmental landmarks also impact anxiety like behavior offspring isdn published elsevier ltd rights reserved
developing electric vehicle industry generally considered effective way easing imbalance supply demand oil addition pressure reduce environmental pollution developed countries developing countries including brazil russia india china called eric countries actively promoting development evs studying different types widely used gasoline internal combustion engine vehicles icevs evs compare effect environment utilizing evs developed developing countries achieved using well wheel method results show compared gasoline icevs evs significant effect emission reduction however correspciriding air pollution due pmio etc given varies substantially different countries influence several factors electrical power structure lirie loss rate developing countries use larger proportions thermal power present high line loss rates pollutant emission produced certain much higher developed countries taking china typical developing country example research dynamically predicts environmental effects expected due developing industry predictions based method monte carlo simulation consider government development plan energy finally according results obtained policies suggestions development industry developing countries proposed elsevier ltd rights reserved
background autonomic nervous activity plays critical role genesis paroxysmal atrial fibrillation paf however role autonomic nervous activity termination elucidated heart rate variability hrv widely used evaluate autonomic nervous activity humans purpose study assess whether autonomic nervous activity assessed hrv contributes termination methods electrocardiograms ecgs hrv studied patients termination sustained paf hour ambulatory holter monitoring minute interval termination divided four segments minutes frequency analysis applied minute segment results episodes ultra low frequency power low frequency power low frequency power high frequency power total power significantly decreased time episodes termination ratio normalized lfnu normalized hfnu significantly changed termination eighteen episodes decreased lfnu increased hfnu sympathetic withdrawal vagal activation slower average ventricular responses beats min beats min years higher incidence termination increased lfnu decreased hfnu younger patients aged years conclusion autonomic changes critically regulate termination paf modulated aging
parents play crucial role development children relationships siblings despite relatively evidence based parenting programs exist specifically offer parents strategies techniques desire require managing children sibling relationships one way bridging gap design tailored parenting intervention sibling relationships incorporates parent voice various aspects program design current study recruited convenience sample australian parents complete online survey relating views difficult sibling behaviors help desire dealing issue majority respondents caucasian middle upper class mothers respondents predominantly attributed causes sibling conflict child internal traits expressed strong desire assistance managing behavioral problems especially sibling relationships marked physical aggression respondents reported high levels acceptability positive rather punitive parenting strategies showed clear preference parenting interventions delivered easy access formats findings interpreted context guiding development tailored parenting intervention enhancing sibling relationships reducing conflict
socially assistive robotics important emerging research area socially assistive robotics challenging required move robots laboratories industrial settings interact ordinary human beings peers requires social skills design process usually requires multidisciplinary research teams may comprise subject matter experts various domains robotics systems integration medicine psychology gerontology social cognitive sciences neuroscience among many others unlike robotic applications socially assistive robotics faces unique software systems integration challenges paper healthbot robot architecture designed overcome challenges presented presented architecture implemented used several field trials details field trials presented lessons learned discussed field trial results
present study evaluated contribution individual synaptic constituents assessed neurotransmitter systems subjecting available vivo imaging studies patients unipolar major depressive disorder mdd bipolar depression retrospective analysis acute mdd findings revealed significant increases prefrontal frontal synthesis decreases thalamic midbrain sert increases insular sert decreases midbrain hta receptors decreases pre frontal frontal occipital cingulate hta receptors whereas remission decreases striatal receptors midbrain sert frontal parietal temporal occipital cingulate hta receptors parietal hta receptors observed findings indicated trend towards increased striatal receptors depression mania decreased striatal synthesis remission decreased frontal receptors three conditions additionally evidence ventrostriatal hippocampal sert may decreased depression whereas remission mania elevations thalamic midbrain sert respectively observed moreover depression limbic hta receptors elevated whereas mania decrease cortical limbic hta receptor binding observed furthermore depression prefrontal frontal occipital cingulate receptor binding found reduced complex pattern dysregulations within neurotransmitter systems may derived likely causally linked subtype duration disease also predominance individual symptoms kind duration pharmacological treatment elsevier rights reserved
objective validate content new nursing diagnosis termed risk pressure ulcer method content validation sample made nurses specialists skin care six different hospitals south southeast brazil data collection took place electronically instrument constructed using surveymonkey program containing title definition risk factors nursing diagnosis data analyzed using fehring method descriptive statistics project approved research ethics committee results title definition seven risk factors validated important physical immobilization pressure surface friction shearing forces skin moisture alteration sensation malnutrition among risk factors validated important dehydration obesity anemia decrease serum albumin level prematurity aging smoking edema impaired circulation decrease oxygenation tissue perfusion risk factor hyperthermia discarded conclusion content validation components nursing diagnosis corroborated importance able facilitate nurse clinical reasoning guiding clinical practice preventive care pressure ulcers
background infliximab shows good efficacy treating refractory rheumatoid arthritis however many patients responded poorly related studies inconsistent predictive biomarkers study aimed identify circulating biomarkers predicting infliximab response material methods public databases gene expression omnibus geo arrayexpress searched related microarray datasets focused response infliximab peripheral blood samples collected infliximab treatment gene expression profiles measured using microarray differential genes associated infliximab efficacy analyzed genes recognized half datasets regarded candidate biomarkers validated prospective datasets results eight microarray datasets identified blood samples patients among diagnosed non responders subsequent infliximab treatment five genes fkbpa fgf ano lrrc akrd associated efficacy recognized half datasets gene model showed good predictive power random prospective designed studies auc area receiver operating characteristic roc curve also applicable early phase treatment week predicting response week auc placebo group model failed predict response auc indicating model specificity infliximab treatment conclusions model fkbpa fgf ano lrrc akrd peripheral blood useful efficiently predicting response infliximab treatment rheumatoid arthritis
objective aim evaluate diffusion weighted imaging dwi tool measuring treatment response adolescents enthesitis related arthropathy era methods twenty two adolescents era underwent routine mri dwi tnf inhibitor therapy patient images visually scored two radiologists using spondyloarthritis research consortium canada system sacroiliac joint apparent diffusion coefficient adc normalized adc nadc measured patient therapeutic clinical response defined improvement physician global assessment radiological response defined point reduction spondyloarthritis research consortium canada score compared adc nadc changes responders non responders using mann whitney wilcoxon test results radiological clinical definitions response reductions adc nadc treatment greater responders non responders radiological response adc nadc clinical response adc nadc adc nadc could predict radiological response high level sensitivity specificity moderately sensitive specific predictors clinical response area receiver operating characteristic curves follows adc nadc radiological response adc nadc clinical response conclusion dwi measurements reflect response tnf inhibitor treatment era patients sacroiliitis defined using radiological criteria may also reflect clinical response dwi objective visual scoring potential automated adc nadc could used biomarkers sacroiliitis clinic clinical trials
paper presents method solve real time three dimensional workspace generation problem arbitrary serial manipulators approach based monte carlo simulation process high number forward kinematics randomly chosen joint values results asymptotic coverage reachable workspace additionally collision detection integrated consider obstacles within manipulator environment method implemented graphics processing unit gpu extremely high number workspace points processed parallel tests shown approach capable generate acceptable workspace coverage within milliseconds furthermore workspace held three dimensional texture volume graphics memory allowing instant visualisation workspace generation process without need time intensive data exchange
switchable operational amplifier opamp examined brief based current mirror opamp switchable transconductance values contrary switched opamp partial used realize half delay full delay switched capacitor integrators added circuit design complexity shown minimal optimal switching developed brief also shown brief absolute average power consumption less compared design experimental results delta sigma modulator prototype designed cmos employing designated switchable opamp technique show power reduction without degradation sndr sfdr
shock tests set metals show together well known dynamic strength characteristics material dynamic yielding limit spall strength additional characteristics namely threshold structural instability shock compression defect velocity plateau compressive pulse particle velocity variance mesoscale introduced analysis dynamic strength materials structural instability threshold registered uniaxial strain conditions allows resistance penetration tate alekseevskii equation determined copyright authors published elsevier
fuzzy trace theory fit emphasizes use core theoretical principles verbatim gist distinction predict new findings cognitive development counterintuitive perspective theories common sense extent predictions confirmed range phenomena explained expands without increasing complexity theory assumptions examine research recent examples predictions four epochs cognitive development childhood adolescence young adulthood late adulthood first two featured predictions surprising developmental reversals false memory childhood risky decision making adolescence young adulthood ftt predicts retrieval operation figures centrally dual process theories memory recollection bivariate rather univariate late adulthood ftt identifies retrieval operation reconstruction omitted current theories normal memory declines aging pathological declines dementia theory predicts reconstruction major factor declines able forecast future dementia elsevier inc rights reserved
trigeneration system uses one source primary energy providing power heating cooling simultaneously primary source represented either fossil fuels appropriate renewable energy sources biomass biogas solar energy etc paper brief review micro trigeneration systems residential applications reported innovative building integrated micro trigeneration system proposed proposed system based natural gas fueled internal combustion engine micro cogeneration unit heating purposes domestic hot water production cogeneration device fed electric air cooled vapor compression water chiller cooling purposes micro trigeneration system coupled multi family house characterized transmittance values building envelope compliant imposed italian law considered building representative typical italian residential application feasibility proposed trigeneration system investigated using dynamic simulation software trnsys comparison traditional supply based separate energy production analyses performed varying climatic conditions considering buildings located three different italian cities palermo naples milan representative different climatic regions italy primary energy consumption equivalent carbon dioxide emissions well operating costs proposed system evaluated based simulation results according italian scenario compared associated conventional system composed natural gas fired boiler coupled air cooled water electric chiller fed electric grid performed analyses allowed assess energy environmental economic suitability proposed scheme well potential benefits comparison reference plant based separate energy production elsevier ltd rights reserved
introduction study eating behaviour consider presence potential sources bias including social desirability particularly relevant among students nutrition sciences since higher risk eating disorders objective analyse effect social desirability assessment eating behaviour dimensions among nutrition students methods cross sectional study analysed data students nutrition sciences participants completed questionnaire assessing social desirability eating behaviour dimensions emotional external binge eating flexible rigid control eating self efficacy results among males social desirability negative association binge eating among women negative association emotional external binge eating positive association eating self efficacy subsamples social desirability showed significant association two types dietary restraint rigid flexible control discussion overall association social desirability eating behaviour dimensions among students nutrition sciences occurs direction found students areas however alongside similarities stronger association social desirability binge eating among male students nutrition sciences hypothesize may related different knowledge students different areas way perceive face treatment eating disorders conclusion study shows social desirability considered assessing eating behaviour among nutrition students particularly studying external eating binge eating eating self efficacy moreover tailoring interventions reduce possible effects eating behaviour nutritionists dieticians practice consider influence social desirability elsevier ltd rights reserved
sexual addiction prevalent among college students warrants continued examination using descriptive discriminant analysis authors assessed differences attachment style religious coping students clinical range sexual addiction nonclinical range results indicated significant differences groups large effect size specifically attachment anxiety negative religious coping responsible explained variance
background brain networks fmri typically identified using spatial independent component analysis ica yet mathematical constraints provide alternate biologically plausible frameworks generating brain networks non negative matrix factorization nmf would suppress negative bold signal enforcing positivity spatial sparse coding algorithms regularized learning svd would impose local specialization discouragement multitasking total observed activity single voxel originates restricted number possible brain networks new method assumptions independence positivity sparsity encode task related brain networks compared resulting brain networks within scan different constraints used basis functions encode observed functional activity encodings decoded using machine learning using time series weights predict within scan whether subject viewing video listening audio cue rest fmri scans subjects results comparison existing method sparse coding algorithm regularized learning outperformed variations ica predicting task performed within scan using artifact cleaned components nmf algorithms suppressed negative bold signal poorest accuracy compared ica sparse coding algorithms holding constant effect extraction algorithm encodings using sparser spatial networks containing zero valued voxels higher classification accuracy lower classification accuracy occurred extracted spatial maps contained csf regions conclusion success sparse coding algorithms suggests algorithms enforce sparsity discourage multitasking promote local specialization may capture better underlying source processes allow inexhaustible local processes ica negative bold signal may capture task related activations elsevier rights reserved
paper presents comparative study two different fscw machines application integrated motor generator hybrid vehicles first machine design contains conventional concentrated winding recently used many hybrid systems commercial vehicles whereas second machine use new teeth poles concentrated winding optimized magneto motive force design analysis considered machines based performances included evaluation electromagnetic torque torque ripples ohmic losses magnet losses field weakening capability noise analysis temperature behaviour using finite elements machine types investigated compared geometrical electromagnetic constrains considering main electromagnetic thermal aspects new machine show high power capability efficiency low torque ripple low magnet losses noiseless design thermally robust
runtime analysis black box search algorithms provides rigorous performance guarantees aiding algorithm design comparison unfortunately deriving bounds challenging result existing literature focused simplistic algorithms parameter less population pyramid recently proposed goldman punch gecco unbiased black box search algorithm combines local search model based mixing population layering empirical studies outperformed leading genetic algorithms across variety problems provide runtime analysis bit problems help shed light reason effectiveness derive upper runtime bounds linear functions leadingones log concatenated traps size simplified version obtain bound log iff results show competitive best known unbiased genetic algorithms problems suggesting performance generalizes well furthermore find effectiveness relies three major components lending support algorithm design
research renewable less polluting fuels focused biodiesel fuel derive vegetable animal waste oils despite potential decrease atmospheric pollutants greenhouse gases influence nox emissions still uncertain believed biodiesel emissions especially nox vary depending feedstock blend percentage transesterification route better understanding factors help choosing best blend context article aims evaluating variation factors affects nox emissions tests carried stationary internal combustion engine blends methyl ethyl esters made soybean oil palm oil waste frying oil collected university campus analysis results tukey test compare means lead conclusion considering route ethyl blends lower nox emissions palm ethyl ester blends best results also factors taken account soybean methyl ester lowest emissions nox recommend future studies test effect antioxidants nox emissions well test higher blend ratios elsevier ltd rights reserved
testosterone mediates several key aspects male reproduction maintaining high testosterone levels reduce long term survival one proposed pathways testosterone influence survival increased risk parasite infection hormone potential affect transmission sexually transmitted infections promoting behaviours increase sexual contact rates decreasing immune function hypothesized males high concentrations testosterone would increase chances infected sexually transmitted bacteria would manifest increased diversity cloacal bacteria test hypothesis measured circulating testosterone concentrations breeding male rufous collared sparrows zonotrichia capensis collected cloacal swabs quantify bacterial diversity using rrna gene amplicon sequencing positive correlation testosterone concentrations phylogenetic diversity cloacal bacteria addition individuals high medium testosterone concentrations cloacal bacterial communities similar low testosterone individuals finally considering bacterial taxa potential avian pathogens found relative abundance chlamydiae class obligate intracellular parasites positively correlated testosterone concentrations two non exclusive explanations results testosterone affects behaviours lead increased sexual contacts thus exposure acquisition additional phylogenetically diverse bacteria testosterone altering immune system cloacal environment thus making easier bacteria colonize either way data suggest increased exposure sexually transmitted pathogens form cloacal bacteria could cost maintaining high testosterone levels
cognitive control enables successful goal directed behavior resolving conflict opposing action tendencies emotional control arises consequence emotional conflict processing irony negative emotion facilitates cognitive emotional conflict processing unclear emotional conflict processing affected positive emotion humor eeg experiments investigated role positive audiovisual target stimuli cognitive emotional conflict processing participants categorized either spoken vowels cognitive task emotional valence emotional task ignored visual stimulus dimension behaviorally positive target showed influence cognitive conflict processing impeded emotional conflict processing emotional task response time conflict costs higher positive neutral targets eeg observed interaction emotion congruence erp components emotional cognitive conflict processing emotional conflict task conflict effect larger emotional neutral targets thus results show emotion affects conflict processing differently function conflict type emotional valence suggests conflict valence specific mechanisms modulating executive control
comprehensive radiometric characterization raw data format imagery acquired raspberry camera module presented raspberry high performance single board computer designed educate solve real world problems small computer supports camera module uses sony imx megapixel cmos sensor paper shows scientific engineering grade imagery produced raspberry camera module raw imagery shown linear exposure gain iso essential scientific engineering applications dark frame noise exposure stability assessments along flat fielding results spectral response measurements absolute radiometric calibration results described low cost imaging sensor calibrated produce scientific quality data used computer vision biophotonics remote sensing astronomy high dynamic range imaging security applications name authors published spie creative commons attribution unported license distribution reproduction work whole part requires full attribution original publication including
zinc finger transcription factor prdm domain containing plays key roles development malignant lymphoma leukaemia non haematopoietic cancers including breast cancer colorectal cancer glioma however little known regarding function prdm progression lung cancer found prdm expressed normal human lung epithelium downregulated lung cancer cells decreased expression prdm correlates poor prognosis lung cancer depletion prdm lung cancer cells promotes cellular invasion anoikis resistance vitro lung metastasis vivo prdm silenced ectopically expressed lymphocyte specific transcription factor aiolos transcription two genes negatively correlated lung epithelial cell lines results indicate prdm functions tumour suppressor lung cancer
background reduction sugar sweetened beverage ssb intake may beneficial weight management related health conditions however knowledge data exist regarding spontaneous changes dietary components overall dietary quality ssb reduction intervention objectives explored longitudinal changes within ssb reduction intervention sipsmarter physical activity intervention movemore respect spontaneous changes energy intake macronutrients micronutrients dietary quality healthy eating index hei beverage categories design participants enrolled community based behavioral trial randomly assigned either sipsmarter intervention group movemore matched contact comparison group dietary intake assessed mean three dietary recalls baseline dietary recalls analyzed use nutritional analysis software multilevel mixed effects linear regression intention treat analyses presented results sipsmarter participants showed significant reduction total ssbs mean decrease several spontaneous changes occurred within sipsmarter group compared movemore group included significant hei improvements empty calorie total vegetable total hei scores mean increases respectively additional positive changes shown including significant decreases total energy intake trans fat added sugars total beverage energy dietary changes noted movemore group intervention conclusions intervention single dietary component ssb resulted additional spontaneous beneficial dietary changes interventions target single dietary change limiting ssb intake may improve overall dietary quality health provide motivation make additional dietary changes
mentoring continues build momentum among startups established enterprises due positive impact individuals organizations unlike previous studies research focuses mentoring higher level leadership ceo demonstrates unique relationship organizational innovativeness sample included mentored executives entrepreneurs personally identify exploit opportunities findings confirm mentoring top leaders positively relates perceived innovativeness organization relationship mediated leaders perception psychological safety within organization findings also confirm relationship negatively moderated leaders cognitive adaptability reliability validity results proved using confirmatory factor analysis advanced regression analytics result work demonstrates value mentoring top leadership advocates importance establishing psychologically safe environment inspire top leadership try new avenues also within organization speak speak additionally findings encourage organizations proactively selectively prioritize mentoring among top leadership taking account differing levels cognitive adaptability finally research could focus provide greater support mentors higher level leaders
second order generalised integrator resonant integrator wide range applications forward backward euler approximation based two integrator realisation easily implementable frequency adaptive method however suffers resonant frequency deviation due discretisation discretisation methods lead accurate realisation require online calculation lookup table trigonometric functions accommodate frequency variation study multi rate computation based implementation two integrator based proposed minimise resonant frequency deviation method additional logic elements consumed achieve accurate resonant frequency location along sampling leads lesser phase lag effect quantisation resonant frequency deviation analysed proper choice calculation time also shown appropriate choice sampling instants give range phase response characteristics around nominal continuous time phase response accuracy resonant frequency emulation experimentally verified implementing proportional resonant controller current controller
study investigated formation amorphous system tranilast trl diphenhydramine hydrochloride dph drugs used treating allergies inflammation crystallization undercooled melts drugs drug mixtures evaluated thermal analysis drugs amorphous state underwent crystallization heating although mixture remained amorphous state indicating formation amorphous system physico chemical properties amorphous trl dph prepared melting cooling process studied glass transition temperature amorphous trl dph deviated theoretical value enthalpy relaxation rate amorphous drugs reflected molecular mobility reduced formation amorphous system intermolecular interactions trl dph amorphous system measured change spectra results consistent high physical stability amorphous sample remained amorphous state days degrees whereas amorphous drugs showed rapid crystallization findings demonstrate trl dph form amorphous system dramatically decreases crystallization without excipient american pharmacists association published elsevier inc rights reserved
fifty seven dromedary camel foetuses crown vertebral rump length ranging collected slaughter house processed morphological histological studies kidney metanephros detected attained permanent kidney like structure camel foetuses
clinical importance thyroid nodules patients axial spondyloarthritis spa rests need exclude thyroid malignancy aim study assess risk thyroid malignancy spa patients receiving anti tnf therapy september december patients diagnosed spa included research forty patients received anti tnf therapy patients anti tnf naive cases screened presence nodules thyroid gland ultrasound patients received anti tnf therapy anti tnf naive patients thyroid nodule four patients anti tnf group underwent fine needle aspiration biopsy nodules two diagnosed papillary thyroid carcinoma none nodules anti tnf naive patients required biopsy compared normal population standardized incidence ratio sir found increased male sir female sir cases yet established whether development cancer treatment process effect treatment part natural course disease coincidental saw mild increase thyroid malignancies spa patients received anti tnf therapy therefore believe thyroid gland also taken consideration screening malignancy anti tnf therapy
quantum key distribution qkd enables provably secure communication two parties optical fiber arguably withstands form attack besides need suitable physical signalling scheme corresponding devices qkd also requires secret key distillation protocol protocol involved signal processing handle reliable key agreement process fragile quantum channel well necessary post processing key bits avoid leakage secret key information eavesdropper paper present detail implementation key distillation engine qkd system based coherent one way cow protocol processing key bits key distillation engine includes agreement quantum bit detections sifting information reconciliation forward error correction coding parameter estimation privacy amplification authenticated channel detail system architecture combining processing steps discuss design trade offs individual system module also assess performance efficiency key distillation implementation terms throughput error correction capabilities resource utilization single fpga xilinx virtex lxt platform system supports distilled key rates mbps
hydraulic jump phenomenon usually occurs rivers correspondence hydraulic structures characterized rapid transition super sub critical flow conditions involving huge energy dissipation characteristics relevance hydraulics studied since early years last century nevertheless many features still require investigation scale effects air entrainment process effect bed roughness conjugate depths etc particular last decades analysis main geometric parameters developed nevertheless studies dealing jump occurring rough sloping channel present literature therefore present paper reports results experimental investigations allowed develop semi theoretical approach order evaluate jump conjugate depth wide range channel bed geometric boundary configurations international association hydro environment engineering research asia pacific division published elsevier rights reserved
complexity humanoid robots increasing availability new sensors embedded cpus actuators wealth technologies allows researchers investigate new problems like multi modal sensory fusion whole body control multi modal human robot interaction hood robots software architecture important role allows researchers get access robot functionalities focusing primarily research problems supports code reuse minimize development debugging especially new hardware becomes available importantly allows increasing complexity experiments carried system integration becomes unmanageable debugging draws resources research paper illustrate software architecture icub humanoid robot software engineering best practices emerged driven needs research community describe latest development middleware supporting interface definition automatic code generation logging ros compatibility channel prioritization show robot abstraction layer modified better address requirements users support new hardware became available also describe testing framework recently adopted developing code using test driven methodology conclude paper discussing lessons learned past years software development icub humanoid robot
paper present operational amplifier amp pulsewidth modulation pwm controller fabricated amorphous indium gallium zinc oxide thin film transistors ingazno tfts build adaptive converter display driving systems fabricated ingazno tft presents electrical characteristics suitable accomplishing amp composed type tfts overall gain cutoff frequency khz unit gain frequency khz operating fabricated amp used construct comparator error amplifier glass combined realize pwm controller resulting pwm controller successfully control output voltage external converter follows input voltage error amplifier operate control duty ratio reference voltage varies respectively
increasing evidence indicates strong link intestinal health bone health example inflammatory bowel disease cause systemic inflammation weight loss extra intestinal manifestations decreased bone growth density however effects moderate intestinal inflammation without weight loss bone health never directly examined yet condition relevant ibd conditions increased intestinal permeability inflammation seen ingestion high fat diets intestinal dysbiosis irritable bowel syndrome metabolic syndrome food allergies induced moderate intestinal inflammation without weight loss young male mice treating low dose dextran sodium sulfate days mice displayed systemic changes marked significant bone loss redistribution fat subcutaneous visceral fat pad stores bone loss caused reduced osteoblast activity characterized decreased expression osteoblast markers runx osteocalcin histomorphometry dynamic measures bone formation addition observed reduction growth plate thickness hypertrophic chondrocyte matrix components collagen correlation analyses indicate link gut inflammation disease score importantly observed bone density measures negatively correlated intestinal disease score well colon bone tnf alpha levels studies demonstrate colitis induced bone loss dependent upon weight loss support role inflammation link gut bone health important area future therapeutic development
quantum secure direct communication qsdc important branch quantum cryptography transmit secret information directly without establishing key first unlike quantum key distribution requires precursory event propose qsdc scheme applying frequency coding technique two step qsdc protocol enables two step qsdc protocol work noisy environment numerically simulated performance protocol noisy channel results show scheme indeed robust channel noise loss also give estimate channel noise upper bound
paper presents investigation behavior cfdst members low velocity lateral impact using abaqus nonlinear material behavior strain rates steel concrete included finite element analysis fea models cfdst members described verified using existing experimental results strain stress states concrete steel tube cfdst members analyzed full loading range followed parametric study investigating influence impact height hollow ratio nominal steel ratio diameter thickness ratio inner steel tube strength materials impact force global residual lateral deformation furthermore dynamic increase factor dif cfdst members lateral impact proposed influence confinement factor dynamic increase factor dif analyzed results show confinement factor larger dynamic increase factor needs considered accurately estimate dynamic resistance capacity cfdst members subjected lateral impact elsevier ltd rights reserved
recent rise virtual augmented reality applications ambient intelligence well video games encouraged proliferation gestural input devices razer hydra leap motion controller kinect devices relay data standard format application developers forced use different application programming interface api device main objective research define implement lager language gesture representation language representation interpretation two three dimensional device agnostic gestures lager developers define gestures processed regardless device apis involved ease use lager lager workbench developed set tools software libraries convert gestures lager strings recognize strings gestures visualize originating gestures communicate detections subscribing programs addition lager effectiveness validated experiments lager workbench used give users control representative functionality google chrome web browser using two hand gestures razer hydra device lager found simple yet expressive enough represent gestures develop gesture based device agnostic applications
background androgen deficiency confers independent risk cardiovascular events total mortality hypertension major contributory factor development cardiovascular disease also associated increased prevalence low testosterone investigated whether low androgen concentration predicts incident major adverse cardiovascular events mace middle aged nondiabetic hypertensive patients without clinical atherosclerosis methods mace relation total testosterone analyzed proportional hazards models male patients mean age years results mean follow months participants experienced mace compared patients experience mace hypertensive subjects developed mace lower concentration higher prevalence hypogonadism subjects lowest tertile multivariate cox models adjusted age systolic blood pressure risk factors plasma level associated negative predictive value ability rule mace addition standard risk factors model yielded net reclassification improvement conclusions results show low plasma testosterone associated increased risk mace hypertensive patients low endogenous androgen concentration improves risk prediction added standard risk factors may represent valuable biomarker prediction cardiovascular disease risk patients
sports injuries increased today due rise interest towards every branch sports injuries occur part body sports injuries highly considered terms athletes future medicine study aims research shoulder injuries treatment methods within scope upper extremity result athlete injury accordingly present researchers incidence applications anatomical structure shoulder joint intense usage set ground injury many conservative surgical methods exist shoulder injuries become conventional like physical therapy injections become quite popular recent years researchers clinical application athlete patients treated various shoulder problems methods enabled athlete patients return sports short time short range fruitful surgical applications physiotherapy methods supported injection study methods used going back sports short time explained
background despite theoretical links eating disorders perfectionism definition perfectionism practice complicated present study explored descriptions experiences perfectionism described transdiagnostic sample patients methods depth semi structured interviews carried patients interviews analyzed thematic analysis comparison patients scorings eating disorder inventory perfectionism scale also performed results seven themes found origins perfectionism top performance order self control perfect body looking good eyes others double edged coping strategy sisyphean task women study emphasize weight body main perfectionistic strivings core descriptions instead order self control top performances participants described awareness reaching perfectionism impossible scorings self oriented perfectionism significantly higher compared socially prescribed perfectionism differences narratives related perfectionism scores eating disorder diagnoses found conclusions results showed psychometric measures always capture patients definitions perfectionism regarding perfectionism serves means regulate affects may lead exacerbation eating disorder development obsessive compulsive symptoms important investigate personal definitions perfectionism
role thyroid hormone adult mammalian brain function including cholinergic neurotransmission illusive clinical application recovery mood disorder altered thyroidal conditions appears dispersed study explored whether supplementation helps recovery adult brain status thyroid dysfunction observed dose dependent stimulation acetylcholinesterase ache activities triiodothyronine synaptosomes prepared adult rat cerebral cortex ache activation propylthiouracil ptu treated treated animals remained elevated indicating presence autoregulatory mechanism thyroid hormone levels altered thyroidal conditions additive effects also found gradual decreases enzyme activities single injection ptu treated rats appears exhibit stimulatory effect cholinergic neurotransmission adult mammalian brain moreover histomorphological observation thyroid gland revealed disappearance colloids changes follicular structures day ptu treated condition colloids reappeared follicular structures normalized single injection ptu treated animals gradually results therefore indicates supplementation augment hypothyroid induced alterations central cholinergic neurotransmission vis vis peripheral thyroid morphology
dementia lewy bodies dlb second common neurodegenerative dementia accurate diagnosis often possible neuropathological examination morphologic hallmarks presence synuclein rich lewy bodies lewy neurites identical seen parkinson disease parkinson disease dementia pdd neurotransmitter deficits synaptic ubiquitin proteasome system ups dysfunction play major role pathomechanism characteristic symptoms cognitive fluctuation parkinsonism visual hallucinations due often atypical clinical presentation novel imaging techniques biomarkers could help early diagnosis although curative treatment available therapies improve quality life clinicopathological studies important exploring pathomechanisms ensuring accurate diagnosis identifying therapeutic targets
purpose review availability children health exposure assessment resource funded national institute environmental health sciences provides new opportunities exploring role tobacco smoke exposure causing harm children recent findings children smokers exposed nicotine harmful tobacco smoke chemicals utero well environment passive exposure tobacco smoke variety negative effects children utero exposure tobacco smoke causes poor birth outcomes influences lung cardiovascular brain development placing children increased risk number adverse health outcomes later life obesity behavioral problems cardiovascular disease furthermore smokers start adolescence age increased nicotine addiction risk biomarkers tobacco exposure helps clarify role tobacco chemicals play influencing health childhood beyond although electronic cigarettes cigarettes appear nicotine delivery device reduced harm appears gateway use combustible cigarette smoking adolescents summary pediatric researchers interested elucidating role tobacco smoke exposure adverse outcomes children incorporate biomarkers tobacco exposure studies
satsuma myomphala critically endangered loss natural habitats predation natural enemies indiscriminate collection protected species korea lacks genomic resources understanding varied functional processes attributable evolutionary success natural habitats assessing genetic information myomphala performed first time novo transcriptome sequencing functional annotation expressed sequences using illumina next generation sequencing ngs platform bioinformatics analysis identified unigenes annotated panm protostome unigene cog clusters orthologous groups databases respectively addition unigenes predicted gene ontology functional categories assigned single category furthermore sequences enzyme commission numbers mapped pathways kyoto encyclopedia genes genomes pathway database prominent protein domains included zinc finger like reverse transcriptase thioredoxin like fold rna recognition motif domain many unigenes homology immunity defense reproduction related genes screened transcriptome also detected putative simple sequence repeats ssrs encompassing dinucleotide hexanucleotide repeat motifs unigene sequences list pcr primers ssr loci identified study genetic polymorphisms transcriptome data represents valuable resource investigations species genome structure biology unigenes information microsatellites would provide indispensable tool conservation species natural adaptive environments authors published elsevier inc
foley published findings journal role prenatal exposure propionic acid ppa behavioral outcomes treated rat pups authors show ppa treated pups displayed subtle differences behavior including nest seeking novel object recognition locomotor activity others previously proposed ppa infusion rat could represent valid animal model asd since many diagnostic criteria disorder spectrum manifest conditions pathogenic makeover gut microbiome facilitate growth microbes capable producing ppa like clostridia species proposed infectious contributing etiology ppa model asd however reason pathogenic microbial overgrowth clear discussion highlights previously identified novel environmental factor nitrous oxide etiopathogenesis asd related neuropathology posits altered ppa metabolism asd may represent key manifestation particular exposure trace environmental exposure may induce release endogenous opioid peptides shown confer virulence advantage certain microbes like pseudomonas aeruginosa pathogenic overproduction ppa asd may compensatory mechanism curb enhanced virulence potential therefore future research ppa model asd consider role consequence environmental exposure isdn published elsevier ltd rights reserved
comes pursuit happiness popular culture encourages focus oneself contrast substantial evidence suggests consistently makes people happy focusing prosocially others current study contrasted mood well boosting effects prosocial behavior acts kindness others world self oriented behavior acts kindness oneself week longitudinal experiment across diverse sample participants found types prosocial behavior led greater increases psychological flourishing self focused neutral behavior addition provide evidence mechanisms explaining relative improvements flourishing among prompted acts kindness namely increases positive emotions decreases negative emotions assigned engage self focused behavior report improved psychological flourishing positive emotions negative emotions relative controls results study contribute growing literature supporting benefits prosocial behavior challenge popular perception focusing oneself optimal strategy boost one mood people striving happiness may tempted treat results however suggest may successful opt treat someone else instead
research presented article product supreme court fellowship office counselor chief justice founded former chief justice warren burger purpose supreme court fellows program bring mid career professionals interested judicial branch governance washington help advance mission goals judiciary working office serves extension chief justice chambers provided unparalleled access learn first hand federal courts managed operated chief justice united states directs managerial budgetary policy priorities federal judiciary chief justice members supreme court cultivate relationships members legislative executive branches secure resources needed federal court system carry constitutional obligations judicial responsibilities article focuses specifically sequestration important policy budgetary issue currently affecting federal court system topic focal point fellowship year currently extreme budget cuts prohibiting federal courts judicial branch agencies across country carrying responsibilities individuals serve congress continues enforcing sequester third branch government longer able contribute american constitutional order efficient effective responsive manner consequently rule law united states jeopardy
teaching subject system identification adaptive control master students challenging task view providing platform achieve teaching learning adaptive control effectively paper proposes real time robotic adaptive control experiment robotic system consists flexible links subjected varied payloads link flexure robot parameters conditions uncertain thus necessitating adaptive control handle payload variations simple regressor based adaptive control designed linear parametric representation highly nonlinear coupled dynamics robot flexible links flexible robot reinforce student concept design development implementation adaptive control experiments undertaken real time different payloads attempts made make students understanding clear adaptive controller performs well situations varied parameters possible obtain fixed gain controller
since centers medicare medicaid services cms distributed quality star ratings medicare advantage contracts better inform medicare eligible individuals plan quality paper examines extent quality star rating scheme affected insurer behavior market identify causal effect star ratings premiums using regression discontinuity design exploits plausibly random variation around threshold values underlying star rating calculations find contracts higher star ratings significantly increased average monthly premiums relative contracts respective threshold values increases per month among star contracts present additional evidence estimated premium increases purely result demand shifts prior year furthermore star ratings significant effect plan mix star contracts disproportionately dropped premium plans star contracts disproportionately expanded plans new markets particularly plans positive monthly premiums broadly analysis reveals relatively large supply side response published quality ratings suggesting level caution policy makers extend quality rating systems new health care markets
growing evidence suggests changes histone acetylation specific sites chromatin modulate neuronal plasticity contribute antidepressant like action sirtuin sirt class iii nad dependent histone deacetylase involved transcriptional repression genes regulating synaptic plasticity importantly key role glutamate system prefrontal cortex pfc synaptic plasticity changes induced antidepressants suggested asked whether sirt could pharmacological target depression therapy compound fluorophenethyloxy phenylamino benzamide selective sirt inhibitor vitro studied mice firstly inhibitory effect subchronic days sirt activity pfc evaluated moreover effect sirt inhibition expression synaptic plasticity markers linked glutamate neurotransmission vgluti synaptophysin mglur gua gunb gluna serotonin levels studied neurochemical behavioral effects chronic weeks chronic mild stress cms model analyzed subchronic inhibited sirt increased gluna giunb serotonin levels pfc moreover chronic reverted cms induced anhedonia social avoidance moreover upregulated postsynaptic giunb phosphorylated form giuai glual suggesting sirt inhibition enhance synaptic strength yet cms also increased gluna glunb postsynaptic fraction results suggest sirt inhibition induce antidepressant like action effect could mediated modulation glutamate serotonin system pfc moreover highlights therapeutic potential sirt inhibitors new antidepressant agents elsevier ltd rights reserved
progression parkinson disease seems vary according disease stage greatly influences management patients however underlying mechanismof progression remains unclear study designed explore progressive pattern iron accumulation different stages patients sixty right handed patients normal controls recruited according disease stage patients hoehn yahr stage grouped early stage epd late stage lpd groups respectively iron content cardinal subcortical nuclei covering cerebrum cerebellum midbrain measured using quantitative susceptibility mapping qsm substantia nigra pars compacta snc showed significantly increased qsm values epd patients compared controls lpd patients snc continued show increased qsm values compared controls epd patients regions showing increased qsm values spread include substantia nigra pars reticulata snr red nucleus globus pallidus data also indicated iron deposition significant internal segment gpi external segment regions showed significant changes qsm values among groups therefore able confirm regionally progressive pattern iron accumulation different stages indicating iron deposition snc affected exclusively early stages disease snr particularly gpi segment become involved advanced stages disease preliminary study providing objective evidence iron related progression copyright john wiley sons ltd
mounting frequency intensity natural hazards alongside growing interdependencies social technical ecological systems placing increased pressure emergency management particularly true strategic level emergency management involves planning managing non routine high consequence events drawing literature survey interviews workshops australia senior emergency managers paper presents analysis five core challenges pressures creating strategic level emergency management argues emphasising emergency management primary adaptation strategy retrograde step ignores importance addressing socio political drivers vulnerabilities three key suggestions presented could assist country strategic level emergency management tackling challenges reframe emergency management component disaster risk reduction rather one adopt network governance approach iii develop capacities strategic level emergency managers
due ever increasing efficiency computer systems symmetric cryptosystem becoming vulnerable linear cryptanalysis brute force attacks example des short key bits becoming easier break aes much longer key size bits makes difficult crack using even advanced dedicated cryptanalysis computers however complex algorithms exhibit better confusion diffusion characteristics always required algorithms must stronger resistance differential linear cryptanalysis attacks paper describes development algorithm implements pseudo random number generator prng order increase key generation complexity experimental results des aes cryptosystems complemented prng shown average improvement avalanche error computation original standard systems considerable improvement time complexity systems
moderate resolution atmospheric transmission modtran commercial remote sensing software package widely used simulate radiative transfer electromagnetic radiation earth atmosphere radiation observed remote sensor however large datasets must processed simulation applications global scale extremely time consuming operate modtran modern workstation circumstance use parallel cluster computing speed process becomes vital time consuming task paper presents pmodtran implementation parallel task scheduling algorithm based modtran pmodtran able reduce processing time test cases used months workstation less week local computer cluster addition pmodtran distribute tasks different levels granularity extra features dynamic load balancing parameter checking
paper presents theoretical practical results dynamic analysis frequency response control llc resonant converter operating wide input voltage load variations nonlinear model llc resonant converter developed using extended describing function method based derived model nonlinear observer based controller designed implemented digital signal processor transient responses obtained input voltage output load variations show proposed controller capable stabilize output effectively experimental results prove superiority proposed observer based controller conventional pid controller
finding critical factors influence pressure pumping concrete investigated years fluid mechanics relationship pressure flow rate radius viscosity known practical guidelines pumping conventional vibrated concrete cvc viscosity term replaced concrete yield stress however recently influence viscosity pumping pressure reevaluated self consolidating concrete scc paper influence concrete rheology tribology flow rate pipe radius pumping pressure discussed based full scale pumping tests concrete mixtures varied pumpable cvc segregating scc influence flow rate viscosity pumping concrete confirmed also shown decrease pipe radius pumping pressure roughly doubled increase yield stress also increases pumping pressure influence visible viscosity approximately constant total flow resistance tribometer also appears correlate well pumping pressure proving developed tribometer mimics quite well flow concrete pipe elsevier ltd rights reserved
laboratory guinea pig cavia porcellus shares humans many similarities pregnancy prenatal development including precocial offspring social dependence similarities suggest guinea pig promising model fetal behavioral development well using innovative methods behavioral acclimation fetal offspring female iaf hairless guinea pigs time mated nih multicolored hartley males observed longitudinally without restraint using noninvasive ultrasound weekly intervals across week gestation ensure ultrasound procedure cause significant stress salivary cortisol collected observation measures fetal spontaneous movement behavioral state quantified video recordings week last week birth results prenatal quantification interlimb movement synchrony state organization reveal guinea pig fetal development strikingly similar previously reported rodents preterm human infants salivary cortisol readings taken sonography differ observation time point results suggest model holds translational promise studying prenatal mechanisms neurobehavioral development including may result adverse events guinea pig highly social mammal wide range socially oriented vocalizations model may also utility studying prenatal origins trajectories developmental disabilities social emotional components autism elsevier rights reserved
aim improving detection novel single nucleotide polymorphisms snps genetic association studies propose method including prior biological information bayesian shrinkage model jointly estimates snp effects assume snp effects follow normal distribution centered zero variance controlled shrinkage hyperparameter use biological information define amount shrinkage applied snp effects distribution effects snps biological support less shrunk toward zero thus likely detected performance method tested simulation study datasets subjects approximate snps linkage disequilibrium blocks using continuous binary outcome tested empirical example body mass index continuous overweight binary dataset subjects snps blocks biological knowledge retrieved using bioinformatics tool dintor queried various databases joint bayesian model inclusion prior information outperformed standard analysis simulation study mean ranking true block bayesian model versus standard analysis individual snps empirical example mean ranking six true blocks versus standard analysis results suggest method powerful standard analysis expect performance improve biological information snps becomes available
activation canonical wingless related integration site wnt beta catenin signaling pathway associated malignant transformation development fibrosis angiogenesis analyzed beta catenin mrna expression bone marrow patients primary pmf secondary smf myelofibrosis control participants using quantitative real time polymerase chain reaction qrt pcr beta catenin expression increased pmf smf might potentiate anemia introduction beta catenin central effector molecule canonical wingless related integration site wnt signaling pathway important maintenance stem cell homeostasis aberrant activation implicated wide array malignant hematological disorders reports suggesting dysregulation philadelphia chromosome negative myeloproliferative neoplasms mpns patients methods analyzed beta catenin mrna expression bone marrow aspirates patients primary pmf patients secondary post mpn myelofibrosis smf using quantitative real time polymerase chain reaction qrt pcr control group consisted aspirates patients limited stage aggressive non hodgkin lymphoma without involvement compared relative gene expression clinical hematological parameters results relative expression catenin differed significantly among groups significantly higher patients pmf smf control group differ patients pmf smf negative correlation found regarding hemoglobin level pmf association according janus kinase jak mutational status jak allele burden detected conclusion results show first time beta catenin mrna expression increased patients pmf smf upregulation might potentiate anemia number inflammatory cytokines associated pmf capable mediating effects increased beta catenin expression accordingly beta catenin induce expression number genes implicated processes cell cycle control fibrosis angiogenesis central pmf pathogenesis therefore beta catenin might represent interesting new therapeutic target diseases
rationale aims objectivesbaseline thyroid function testing regular follow thyroid function amiodarone usage recommended guidelines little known status amiodarone monitoring real world clinical care taiwan objective determine rate thyroid monitoring assess clinical physicians characteristics associated adequate monitoring tertiary referral centre arrhythmia methodswe reviewed medical records patients receiving amiodarone period taipei veterans general hospital rate baseline follow thyroid function monitoring amiodarone therapy calculated factors associated guideline adherence monitoring analysed resultsamong enrolled cases underwent baseline thyroid function testing received measurement anti thyroid peroxidase antibody amiodarone initiation regular follow thyroid function amiodarone usage occurred cases baseline thyroid function likely present patients younger age female sex received amiodarone therapy cardiologists electrophysiologists fewer years service upon multivariate analysis physicians expertise cardiologist versus non cardiologist years service significantly associated adequate thyroid monitoring conclusionsthe rate thyroid monitoring amiodarone therapy suboptimal strategies enhance guideline adherence needed
transfinite barycentric kernels continuous version traditional barycentric coordinates used define interpolants values given smooth planar contour data two dimensional boundary planar map kernels may conveniently expressed using complex number algebra simplifying much notation results paper develop basic complex valued algebra needed describe planar maps use define similarity kernels natural alternative usual barycentric kernels develop theory behind similarity kernels explore properties show transfinite versions popular three point barycentric coordinates laplace mean value wachspress surprisingly simple similarity kernels furthermore show similarity kernels may used invert injective transfinite barycentric mappings using iterative algorithm converges quite rapidly useful rendering images deformed planar barycentric mappings
paraneoplastic cerebellar ataxia pca frequently observed gynaecological cancers small cell lung cancer breast cancer hodgkin lymphoma cancer testis malignant thymoma literature data related effects pca pregnancy reports effects anaesthesia patients pca present management pregnant woman pca suddenly unable walk pca effective spinal anaesthesia performed elective caesarean section complications
background purpose study examine baseline function results arthroscopic cuff repair shoulders small medium sized full thickness cuff tears complete supraspinatus disruption compared intact anterior supraspinatus tendon methods study evaluated subjects small medium sized cuff tears subjects grouped according anterior supraspinatus integrity shoulders intact group shoulders anterior supraspinatus tendon disruption group functional assessments included visual analogue scale pain american shoulder elbow surgeons ases score simple shoulder test score constant score repair integrity assessed ultrasound examination results group shoulders greater mean tear width length area greater supraspinatus muscle degenerative changes compared shoulders intact anterior supraspinatus tendon differences demographics baseline function ases score group group constant score group group surgery differences functional parameter ases score group group constant score group group surgery difference tendon healing rates group group conclusions setting painful small medium sized rotator cuff tears disruption anterior supraspinatus tendon associated greater tear size advanced supraspinatus muscle degeneration however anterior supraspinatus tendon integrity influence clinical presentation functional structural results cuff repair surgery level evidence level iii retrospective cohort treatment study journal shoulder elbow surgery board trustees
netball involves rapid acceleration deceleration directional changes exerting considerable force articular peri articular structures resulting high risk injuries preventing injuries ankle knee joints netball players particular concern improvement core stability neuromuscular control nmc biomechanics proven reduce knee injuries within sporting population improvement proprioception effective reducing ankle injuries playing surfaces higher friction values seem elevate rate injuries aim study assess participation preventative training modalities reduce joint injuries occur frequently cohort elite south african netball players effect playing surface injury rates also assessed subjects participated three elite netball tournaments south africa means questionnaire found injured netball players exercises improve core stability nmc proprioception cement playing surface delivered times higher injury rate synthetic surface netball coaches educated value implementation exercise modalities could limit injuries ankle knee joints netball players
multilevel data structures common social sciences often nested data analysed multilevel models mlms heterogeneity clusters modelled continuously distributed random intercepts slopes alternatively non parametric multilevel regression mixture model npmm accommodate nested data structures discrete latent class variation purpose article delineate analytic relationships npmm mlm parameters useful understanding indirect interpretation npmm non parametric approximation mlm relaxed distributional assumptions define seven standard non standard mlm specifications indirectly approximated particular npmm specifications provide formulas showing npmm serve approximation mlm terms intraclass correlation random coefficient means variances heteroscedasticity residuals level heteroscedasticity residuals level discuss relationships useful practice specific relationships illustrated simulated graphical demonstrations direct indirect interpretations npmm classes contrasted provide function aid implementing visualizing indirect interpretation npmm classes empirical example presented future directions discussed
paper presents design realisation technique attenuate hysteresis nonlinear phenomenon piezoelectric actuators piezoelectric actuator widely utilised deformable mirrors used moao power laser beam shaping techniques nonlinearities piezo usually iteratively compensated using closed loop set ups open loop control hysteresis creep piezo corrected thus nonlinearities must removed least minimised concept demonstrated high displacement amplified piezoelectric actuators apa mounted fabry perot interferometer hysteresis attenuation technique aims assist fabry perots nano positioning control system attain main scientific specification system apa maximum stroke within range used position high reflective mirror plate fabry perots nano positioning control system specified limit apas positioning steady state noise rms hysteresis limits positioning accuracy order attenuate hysteresis hybrid amplifier circuit built high power operational amplifier designed applied apa experiments results show hysteresis effect almost eliminated consequently positioning steady state noise significantly reduced excellent results hybrid amplifier patent application introduced june number reviewed
background echocardiographic atrioventricular optimization cardiac resynchronization therapy crt uncommon due time constraints use vendor specific device algorithms remains unclear whether optimization mitral inflow velocities still useful aimed investigate post implantation left ventricular inflow patterns determine incidence dyssynchrony empirically set devices methods retrospective study patients undergoing crt using empiric device settings forty eight patients clinical echocardiographic pacemaker follow grouped post implantation filling pattern baseline characteristics echocardiographic measurements compared post implantation findings median months interquartile range iqr results twenty four patients demonstrated dyssynchrony group crt patients group group patients less reverse remodeling compared group patients delta end diastolic volume delta end systolic volume experience significant improvements outflow tract velocity time integral stroke volume ejection fraction differences new onset atrial fibrillation heart failure readmissions mortality groups conclusion study suggests patients empiric device settings dyssynchrony months despite atrioventricular delay optimization avo algorithms dyssynchrony common proven modifiable strategic approach doppler echocardiography guided avo crt warranted particularly nonresponders filling pattern fused truncated
smart environments possess devices collaborate help user non intrusively one possible aid smart environment offer anticipate user tasks perform behalf facilitate action completion paper propose framework predicts user actions learning behavior interacting smart environment prepare datasets train predictor responsible decide whether target transducer value changed solution achieves significant improvement target transducers studied combinations parameters yields better results base case
pediatric spinal oligodendrogliomas rare aggressive tumors share molecular features adult oligodendroglioma previous reports examined molecular features pediatric spinal oligodendroglioma present case child recurrent spinal anaplastic oligodendroglioma performed whole exome paired tumor germline dna transcriptome tumor rna sequencing revealed somatic mutations fgfr data allowed explore potential personalized therapies patient expose molecular drivers may involved similar cases
aims foetal growth proposed influence cardiovascular health adulthood process referred foetal programming indeed intrauterine growth restriction animal models alters heart size cardiomyocyte number perinatal period yet consequences adult challenged heart largely unknown aim study elucidate postnatal myocardial growth pattern left ventricular function stress response adult heart neonatal cardiac hypoplasia mice methods results utilizing new mouse model impaired cardiac development leading fully functional hypoplastic hearts birth show myocardial mass normalized early adulthood accelerated physiological cardiomyocyte hypertrophy compensatory hypertrophy however maintained upon ageing resulting reduced organ size without maladaptive myocardial remodelling angiotensin stress revealed aberrant cardiomyocyte growth kinetics adult hearts neonatal hypoplasia compared normally developed controls characterized reversible overshooting hypertrophy exaggerated growth mainly depends stat whose inhibition angiotensin treatment reduces left ventricular mass groups causes contractile dysfunction developmentally impaired hearts whereas jak stat inhibition reduces cardiomyocyte cross sectional area latter prevents fibrosis control hearts indicating fundamentally different mechanisms action conclusion impaired prenatal development leading neonatal cardiac hypoplasia alters postnatal cardiac growth stress response vivo thereby linking foetal programming organ size control heart
smart embedded systems often run sophisticated pattern recognition algorithms found many areas like automotive sports medicine developer system often confronted accuracy cost conflict resulting system accurate possible able run resource constraint hardware article introduces method support solution design conflict accuracy cost reports reports compare classification systems regarding classification rate accuracy mathematical operations parameters working phase cost method used deduce specific cost various popular pattern recognition algorithms derive overall cost classification system also show analysis used estimate computational cost specific hardware architectures software toolbox create accuracy cost reports implemented facilitate automatic classification system comparison presented methodology software available download supplementary material performed different experiments synthetic real world data underline value analysis accurate computationally cheap classification systems easily identified even able find better implementation candidate existing embedded classification problem work first step towards comprehensive support tool design embedded classification systems
paper optimal internal model controller imc designed control unstable cascade processes time delays proposed control structure consists two controllers inner loop controller secondary controller designed using imc principles primary controller master controller designed proportional integral derivative pid series lead lag filter based imc scheme using optimal minimisation selection tuning parameter important imc based design present work maximum sensitivity used systematic selection primary loop tuning parameter simulation studies carried various unstable cascade processes present method provides significant improvement compared recently reported methods literature particularly disturbance rejection present method also provides robust closed loop performances large uncertainties process parameters quantitative comparison carried considering integral absolute error iae total variation performance indices elsevier ltd rights reserved
paper analysis technical support data goal identifying process improvement actions reducing interrupts presented technical support chat established used provide internal developer support development teams use software code developed core team paper shows data analysis month support time helped identify gaps action items improving technical support process minimize interrupts developer teams show developers interrupted investigated technical support chat multiple times day interruptions come peak working hours also show interruptions prevented introduction multiple tools dispatcher service policy dispatcher role faq page among others paper also shows effects advantages drawbacks technical support refactor actions taken basis analysis
children exposed multiple sources violence may become desensitized increasing possibility imitating aggressive behaviors watch considering behavior normal purpose article assess association exposure various types violence including war desensitization lebanese children cross sectional design school aged children assessed exposure violence using three surveys violence media media preference survey exposure violence kid save survey desensitization attitudes attitude toward violence child version children years old males middle socioeconomic status ses backgrounds seventy six percent children reported exposed violence exposure males lower ses group impact however greater girls predictors attitude toward violence frequency exposure impact exposure amount violence viewed television children massively exposed violence lebanon resulting desensitization may habituate accept violence normal put risk imitating violent behaviors
pneumocystis jirovecii pneumonia pcp relatively rare complication non hiv patients receiving immunosuppressive treatment since introduction tumour necrosis factor inhibitors cases complication increased report case year old hiv negative patient presented department long history pustular psoriasis poor response traditional treatments last admission developed severe flare unresponsive cyclosporine therefore infliximab initiated third dose developed pcp required admission intensive care unit positive response administration trimethoprim sulfamethoxazole follow mutation ilrn gene compatible deficiency found anakinra started rapid improvement psoriasis pcp severe complication patients receiving immunosuppressive therapy probably underreported dermatologists clinical guidelines pcp prophylaxis dermatological patients receive immunosuppressive biological treatments believe necessary report cases pcp assess real impact complication develop appropriate prophylaxis guidelines
paper presents design compact wearable rechargeable acceleration recorder support long term monitoring ambulatory patients motor disorders software display analyze output device consists microcontroller operational amplifier accelerometer card indicator led rechargeable battery associated minor components operate day without charging continuously collect data three weeks without downloading outside system currently configured slight modifications period could extended several months accompanying software provides flexible visualization acceleration data long periods basic file operations compression easier archiving annotation segments interest functions calculation various parameters detection immobility vibration frequencies applications analysis gait movements discussed
article discusses characteristics several concepts powertrains suitable use purely electric vehicles attention paid given system affects driving dynamics vehicle especially overall drive efficiency based defined driving cycle introduction presents specific types powertrain used modern mass produced electric vehicles following sections describe properties selected devices demonstrated using example high performance virtual electric motor dependence available tractive effort attainable acceleration overall efficacy powertrain one two motors depicted graphically
students learn existence linking process know understand theoretical explanation requires good background compilers operating systems easier explain example showing every change process available tools beginner friendly elf detective aims make linking processes tangible beginners elf detective uses binary executable files thoroughly analyse explain linking phase educational way makes lot easier understand without extensive technical background
paper presents novel realization voltage mode first order pass filter circuit composed single universal voltage conveyor uvc single capacitor three resistors proposed filter provides inverting non inverting outputs configuration simultaneously high input low output impedances desired easy cascading voltage mode operations circuit suitable wideband applications theoretical results verified spice simulations using tsmc cmos process parameters furthermore experimental measurements using uvc integrated circuit
biomass widely used renewable energy source world today used mostly solid form lesser extent form liquid fuels gas utilization biomass energy production increased modest rate modern times biomass major source energy rural turkey biomass used meet variety energy needs including generating electricity heating homes fueling vehicles providing process heat industrial facilities biomass potential includes wood animal plant wastes among biomass energy sources fuel wood seems interesting share total energy production turkey high total biomass energy potential turkey million tons oil equivalents mtoe amount usable biomass potential turkey approximately mtoe electrical production potential usable bioenergy sources corporate income represent jobs study shows important biomass energy potential climate change mitigation energy sustainability turkey elsevier ltd rights reserved
participants asked assess personality big five scales personality politicians shown brief silent video clips probability would vote politicians response surface analyses rsa revealed noteworthy effects self ratings observer ratings openness agreeableness emotional stability voting probability furthermore participants perceived open agreeable emotionally stable extraverted average politician study supports previous findings first impressions affect decision making important issues results also indicate nonverbal information available people prefer political candidates perceive personality traits value authors published elsevier inc
network security risk forecast new research focus network security field though research done forecast research single intrusion attack incidents methods could predict impending single intrusion incidents partial composite intrusion attach behavior extent conducted security risk networks memorylessness property markov model indicates network risk level future times related current state past states impact future risk predictions traditional markov model assumes transmission matrix vary along time work present time varying markov model updating transmission matrix real time addition give formulation risk probability calculation based model able predict incurring probability network risks specific future time
uncertainty neural model influences effectiveness neural model based fdi ftc systems application gmdh approach state space neural model structure selection allows reducing model uncertainty state space representation neural model enables develop new technique estimation neural model inputs based ruif result enables performing robust fault detection isolation actuators
log rank test cornerstone phase iii oncology clinical trials however least three different mathematical procedures named log rank test two widely used commercial statistical programs consequently different values obtained case borderline statistical significance mean difference evidence significant value merely observation since three methods reported name space possible data manipulation occurs particular concern drug regulatory context randomized clinical trials borderline significant results perhaps required report values calculated three methods order properly evaluate drug efficacy interactive excel spreadsheet uses three logrank test variants prepared supplementary file accompanying article association high grade bone marrow fibrosis poor outcome patients myelofibrosis used example
known given directed graph subset vertices sum sigma epsilon vertex projections algebra converges strictly multiplier algebra projection give construction certain cases produces directed graph isomorphic corner pxc corners type arise nawrally fixed point algebras discrete coactions graph algebras related labellings prove fact show construction applicable case whenever labelling satisfies analogue kirchhoff voltage law
introduction impairment visually perceiving backward masked stimuli commonly observed patients schizophrenia yet unclear whether impairment result deficiency first higher order processing subtypes schizophrenia present methods compare identification first order metacognitive higher order performance visual masking paradigm highly homogenous group young firstepisode patients diagnosed paranoid schizophrenia carefully matched healthy controls results find difference across groups first order performance find difference metacognitive performance particularly stimuli relatively high visibility conclusions results indicate masking deficit present first episode patients paranoid schizophrenia primarily impairment metacognition
consider problem performing predecessor searches bounded universe achieving query times depend distribution queries obtain several data structures various properties particular give data structures achieve expected query times logarithmic entropy distribution queries space bounded terms universe size well data structures use linear space query times higher still sublinear functions entropy structures distribution assumed known also consider individual query times universe elements general weights well case distribution known advance
backgrounds gut microbiota increasingly recognized important environmental factor could influence brain function behaviors microbiota gut brain axis method used germ free mice explore effect gut microbiota hippocampal microrna mirna messenger rnas mrnas expression results behavioral tests showed compared specific pathogen free spf mice mice displayed center time center distance less latency familiar food colonization mice gut microbiota spf mice reverse behaviors however differentially expressed mirnas mrnas significantly restored microrna target filter analysis restored mirnas target mrnas among target mrnas target mrnas levels decreased analysis showed significant terms metabolic process binding cell part biological process molecular function cellular component respectively significantly altered pathway axon guidance mmu conclusions findings indicated colonization gut microbiota adolescent mice sufficient reverse behavioral alterations gut microbiota could significantly influence expression levels mirnas mrnas hippocampus results could provide original valuable data researchers study microbiota gut brain axis elsevier rights reserved
economic situation highlights significant role application computer human society since century especially since thesis probes security risk propagation immune mechanism complex network background focusing issue network security network background thesis deploys analysis adopting mechanism model immune mechanism immunizing parts nodes establishing stochastic immune mechanism security risk introducing stochastic immune mechanism propagation model security risk study security risk propagation immune mechanism complex network background thesis presents model rules introduces security risk acquaintance immune mechanism establishes models acquaintances immune mechanism finally attributing simulation experiments simulation results characteristics security risk propagation model study stochastic immune mechanism propagation model acquaintance immune mechanism stochastic model thesis reaches conclusion initial stage propagation die rate security risk inversely proportional propagation rate
jabal akhdar arid mountain region northern oman experienced rapid development last decades resulting deterioration water resources paper applies driving force pressure state impact response dpsir framework integrated environmental assessment tool illustrate cause effect relationships sustainable management water resources area research aimed examine social ecological aspects mountain water explore optimal approaches sustainable use management water resources affected increasing drivers population growth socio economic development agriculture tourism urbanization exerting pressures overconsumption water coupled exogenous pressure climate change decreased rainfall increased water demand resulted degradation water quantity quality declining state water resources reduced area cultivation resulted considerable losses agricultural income omani government adopted responses including water development projects acting reduce pressures well improve state water resources dpsir analysis indicates trade offs made economic development continued supply water agro ecological system choices could prioritization drivers dependence desalinated water introduce reliance non renewable external energy supply unlikely ensure water supply multi century timescale social ecological system addition tourism predominantly based around disappearing agro ecosystems turn dependent supply water therefore efforts directed towards improving water use efficiency installing modern irrigation technology water conservation methods use greywater treated wastewater rainwater harvesting well integrated water resources management climate change mitigation adaptation measures
cortical spreading depolarizations epiphenomenon human brain pathologies associated extensive transient changes ion homeostasis metabolism blood flow previously shown cortical spreading depolarization long lasting consequences brains transcriptome structure particular found cortical spreading depolarization stimulate hippocampal cell proliferation resulting sustained increase adult neurogenesis since hippocampus responsible explicit memory adult born dentate granule neurons contribute function cortical spreading depolarization might influence hippocampus dependent cognition address question induced cortical spreading depolarization cbl mice epidural application mol kcl evaluated neurogenesis behavior two four six weeks thereafter congruent previous findings rats found cortical spreading depolarization increases numbers newborn dentate granule neurons moreover exploratory behavior object location memory consistently enhanced reference memory water maze virtually unaffected whereas memory formation barnes maze impaired delay two weeks facilitated four weeks data show cortical spreading depolarization produces lasting changes psychomotor behavior complex delay task dependent changes spatial memory suggest cortical spreading depolarization like events affect emotional cognitive outcomes associated brain pathologies
hepatocellular carcinoma hcc one malignant lethal cancers single nucleotide polymorphisms snps micrornas mirnas affect expression target identification mirnas lead formation malignant tumors however little known whether microrna mir snps affect susceptibility progression hcc specific mechanism association microrna susceptibility hcc verified massarray assay large case control sample effect mir variant proliferation apoptosis hcc cells examined flow cytometry fcm cck assay western blot target mir identified bioinformatics analysis qrt pcr role cell proliferative capacity examined cck assay expression level mir analyzed qrt pcr hcc cells transfected wild variant type pre mir plasmid mir produced tumor suppressor effect inhibiting cell proliferation inducing apoptosis human hcc cells possibly via inhibiting expression target genes spatsl lrp tumor promoters mir reduced anticancer effect mir possibly attenuating total amount hcc cells target recognition reduce inhibition target genes promoted susceptibility hcc findings first time proved mir snp plays role occurrence process hcc relevant mechanism accompany discovery novel target genes mir
non small cell lung cancer nsclc number one cause global mortality despite aggressive treatment prognosis dismal patients advanced nsclc median survival months time diagnosis fortunately molecularly based approaches drug discovery yielded tyrosine kinase inhibitor crizotinib significantly prolongs median progression free survival subset patients although initial clinical trial results demonstrate crizotinib promising role play nsclc treatment development resistance leaves much elucidated effectively combat deadly disease review follow discovery development crizotinib bench bedside provide example successful bottom drug design explore clinical trial results fast tracked eventual use frontline therapy sensitive nsclc patients development resistance lastly discuss potential future uses crizotinib within beyond nsclc
measurement analysis low level vibrations acoustic emissions components fabrications structures often accomplished utilisation multiple distributed piezoelectric sensors frequencies interest usually commence upper audio range khz typically ultrasonic frequencies mhz measurements intrinsically limited terms dynamic range due signal noise ratio overall system comprising transducer front end signal amplification together associated interconnection cables paper demonstrates latest bipolar operational amplifier technologies rather traditional fet technologies provide better solution higher frequencies ultra low noise systems whilst still delivering high gain bandwidth needed paper also presents comparative noise analysis three principle operational amplifier circuit topologies commonly utilised piezoelectric sensors single ended charge amplifiers differential charge amplifiers voltage mode amplifiers effects transducer cables system configuration also considered noise perspective theoretical analysis verified practical experiment
patients cancer often experience high symptom burden prior start treatment disease treatment related neurotoxicities appear additive targeting disease related symptoms may attenuate overall symptom burden cancer patients improve tolerability treatment hypothesized disease related symptoms consequence tumor induced inflammation tested hypothesis using syngeneic heterotopic murine model human papilloma virus hpv related head neck cancer model advantage mildly aggressive causing cachexia weight loss previously showed tumor leads increased beta tnf alpha expression liver increased beta expression brain current study confirmed features demonstrated tumor exhibits high inflammatory cytokine expression beta tnf alpha compared healthy tissue clear relationship cytokine levels behavioral deficits model behavioral changes surprisingly mild therefore sought confirm relationship behavior inflammation amplifying effect using low dose lipopolysaccharide lps tumor bearing mice lps induced deficits nest building tail suspension locomotor activity approximately lps however mice display exacerbation lps induced weight loss anorexia anhedonia heightened serum observed minimal priming liver brain cytokine expression next sought inhibit tumor induced burrowing deficits reducing inflammation using minocycline minocycline similar day drinking water able attenuate tumor induced inflammation burrowing deficits data provide evidence favor inflammatory like mechanism behavioral alterations associated tumor growth syngeneic murine model hpv related head neck cancer however inflammatory state behavioral changes induced tumor clearly differ forms inflammation induced sickness behavior elsevier ltd rights reserved
real time catheter based ultrasound imaging applications gathering data transducer arrays difficult restriction cable count due diameter catheter although area power hungry multiplexing circuits integrated catheter tip used applications unsuitable use small sized catheters applications intracardiac imaging furthermore length requirement catheters limited power available chip cable drivers leads limited signal strength receiver end paper alternative approach using analog time division multiplexing tdm presented addresses cable restrictions ultrasound catheters novel digital demultiplexing technique also described allows reduction number analog signal processing stages required tdm digital demultiplexing schemes demonstrated intracardiac imaging system would operate mhz range tdm integrated circuit multiplexer interfaced fast analog digital converter adc microcoaxial catheter cable bundle processed field programmable gate array register transfer level simulation input signals tdm recovered crosstalk channels microcoax showing feasibility system ultrasound imaging applications
case control study investigated nutrient intake healthy eating index items foods nutrients day food diaries anthropometric measurements children autism spectrum disorder typically developing children years valencia spain children autism spectrum disorder higher risk underweight eating legumes vegetables fiber micronutrients traditional mediterranean diet fewer dairy cereal products less iodine sodium calcium typically developing peers differences existed total energy intake healthy eating index food variety score differences significant autism spectrum disorder group failed meet dietary recommendations thiamin riboflavin vitamin calcium risk inadequate intake fiber vitamin sodium lower children autism spectrum disorder typically developing children results suggest risk inadequate intake micronutrients children autism spectrum disorder cultural patterns environment may influence food intake anthropometric characteristics autism spectrum disorder primary care include anthropometric nutritional surveillance population identify intervention case case basis future research explore dietary patterns anthropometric characteristics different autism spectrum disorder populations countries enhancing understanding disorder impact
background childhood obesity one serious public health issues twenty first century affecting even low middle income countries overweight obese children likely stay obese adulthood due paucity data local practices study aimed assess knowledge practices physicians middle east north africa region respect early onset obesity methods specific questionnaire investigating perception knowledge early onset obesity circulated healthcare providers general physicians pediatricians pediatric gastroenterologist neonatologists practicing middle east north african countries results total completed forms response evaluated respondents consistently use growth charts monitor growth every visit respondents aware correct cut criterion overweight obesity respectively surveyed respondents consider hypertension type diabetes coronary heart disease fatty liver disease decreased life span respectively long term complication early childhood obesity furthermore respondents correctly answered survey questions pertaining knowledge early childhood overweight obesity conclusion survey highlights low use growth charts evaluation early childhood growth middle east north africa region demonstrated poor knowledge healthcare providers short long term complications early onset obesity suggests need continued professional education development implementation guidelines prevention management early childhood overweight obesity
background attachment anxiety avoidance found associated worry substantial body research suggests intolerance uncertainty iou phenomenon predicts level worry yet relationship attachment iou worry remains investigated methods present study recruited participants community within australia complete online survey incorporating intolerance uncertainty scale experiences close relationships scale revised penn state worry questionnaire results analyses revealed attachment anxiety attachment avoidance positively correlated iou attachment anxiety attachment avoidance iou positively correlated worry furthermore iou found mediate relationship attachment anxiety worry even attachment avoidance entered covariate contrast relationship attachment avoidance worry intolerance uncertainty mediated association attachment anxiety ignored conclusions results study suggest iou may play key role relationship adult attachment difficulties experience worry findings may significant implications conceptualisation psychological treatment attachment related difficulties elsevier ltd rights reserved
binge eating specific form overeating characterized intermittent excessive eating addition altering neurobiological reward system several studies highlighted consumption palatable food increases vulnerability drug use aim present study evaluate effects high fat diet consumed binge pattern adolescence reinforcing effects cocaine days binge eating three days week pnd reinforcing effects cocaine conditioning place preference intravenous self administration paradigm evaluated adolescent male mice circulating leptin ghrelin levels effects bingeing fat opioid receptor mor ghrelin receptor ghsr gene expression nucleus accumbens nacc ventral tegmental area vta also assessed results showed significant escalation consumption high fat diet first last week high fat binge hfb animals sensitive reinforcing effects subthreshold dose cocaine paradigms assayed animals fat withdrawal vulnerable reinstatement conditioned place preference hfb mice also showed enhanced cocaine self administration fat withdrawal exposure new fat binge reinstated cocaine seeking although hfb modify leptin levels decrease plasmatic ghrelin observed moreover pattern fatty diet resulted reduction mor gene expression nacc increase ghsr expression vta propose bingeing fat adolescence induces long lasting changes brain sensitization brain reward circuits predisposes individuals seek cocaine adulthood elsevier ltd rights reserved
goal present research test whether score related changes opponents nonverbal behavior influence athletes confidence beating opponents experiment participants experienced basketball players watched brief video clips depicting athletes nonverbal behavior video clips artificially created showed naturally occurring behavior participants indicated confident beating presented athletes hypothetical scenario results indicated participants confidence estimations influenced opponents score related nonverbal behavior participants less confident beating leading team confident beating trailing team although unaware actual score depicted scenes present research first show game variations naturally occurring nonverbal behavior influence athletes confidence finding highlights importance research nonverbal behavior sports particularly relation athletes confidence
paper fast ion battery charger microcontroller mcu based configurable pulse width modulation pwm controller tracking polarization curve battery cells proposed order inject maximum charge current without battery degradation fully custom designed mcu implemented system chip soc using embedded flash cmos process evaluation results show newly designed charger faster conventional constant current charging method temperature rise within reasonable range implemented charger system tracking battery cell polarization curve results charging cells battery maximum capacity less minutes degrees maximum temperature rise without damaging battery
objectives aim systematic review provide overview evidence effectiveness brief interventions targeting mental health well organizational settings compare effects corresponding interventions common longer duration methods extensive systematic search conducted using medline psycinfo databases period randomized controlled trials rct quasi experimental studies evaluating primary secondary brief interventions carried workplace settings included subsequently common interventions matching brief interventions type assessed outcomes included methodological quality included studies appraised using nice guidelines best evidence synthesis approach applied results review identified brief interventions corresponding common interventions included studies varied substantially sample size characteristics methodological quality duration follow types intervention assessed outcomes one study evaluating brief interventions high risk bias evidence found effectiveness brief stress management relaxation massage mindfulness meditation multimodal interventions found limited evidence effectiveness brief positive psychology interventions conclusions review highlights need high quality studies evaluating brief mental health wellbeing interventions organizational settings future studies use methodologically rigorous designs improved reporting methods results provide conclusive evidence effectiveness sustainability intervention effects
article deals chua circuit characterization point view filter based concept piecewise linear functions furthermore experiments developed teaching electronic systems used novel filtering concepts frequency range tested khz due audio spectrum comprised frequency range node associated capacitor chua diode used input node another capacitor coil used output thereby establishing one input output relationship system case given piecewise linear functions experimental result shows chua circuit behaves bandpass filter amplifier maximum frequency around khz bandwidth khz khz results presented paper motivate engineering students pursue applications novel electrical circuits based topics potential interest future research studies
background dyslipidemia dysregulated adipokine secretion alteration glucagon adropin concentrations important obesity related factors pathophysiology human type diabetes however roles pathophysiology feline diabetes mellitus relatively unknown determined concentrations circulating leptin adiponectin pro inflammatory cytokines glucagon adropin triglycerides cholesterol non diabetic lean overweight cats newly diagnosed diabetic cats client owned cats recruited assigned study groups lean overweight diabetic fasting blood samples analyzed lean overweight diabetic cats baseline weeks consumption high protein low carbohydrate standardized diet results serum concentrations triglycerides greater diabetics baseline increased diabetic overweight cats weeks plasma leptin concentrations greater diabetic overweight baseline weeks whereas adiponectin lower diabetics compared lean overweight cats baseline weeks diabetics greater baseline plasma glucagon concentrations compared lean lower adropin overweight weeks lower concentrations weeks baseline conclusions results suggest feline obesity diabetes mellitus characterized hypertriglyceridemia hyperleptinemia however diabetic cats significantly lower adiponectin adropin compared overweight cats thus despite similar body condition overweight diabetic cats differential circulating concentrations adiponectin adropin
autism global phenomenon yet dearth knowledge understood impact low income countries examined parents professionals understanding autism one low income country nepal conducted focus groups semi structured interviews parents autistic non autistic children education health professionals urban rural settings asking questions typical atypical development presenting vignettes children prompt discussion overall parents typically developing children professionals little explicit awareness autism however use distinctive terms describe children autism children developmental conditions furthermore participants felt environmental factors including utero stressors birth complications parenting style home school environment key causes atypical child development called greater efforts raise awareness build community capacity address autism first study show striking lack awareness autism parents professionals alike results important implications future work nepal aiming estimate prevalence autism enhance support available autistic children families
lesbian gay bisexual lgb individuals begun gain acceptance transgender people yet achieve previous literature found significant effect allport contact hypothesis reducing negative attitudes toward lgb individuals attention recently turned implications social contact reduction transphobic attitudes one study demonstrating efficacy present study examined relationships cisgender heterosexual college students social contact transgender individuals operationalized number friendships self reported attitudes behavioral intentions toward transgender individuals sample undergraduate students mid sized public university completed questions attitudes behaviors toward transgender individuals transgender friendship experiences multivariate analysis variance significant differences participants reported zero versus least one transgender friend across negative intentions negative attitudes positive intentions views supportive public intentions toward transgender individuals found supporting contact hypothesis findings suggest friendships transgender individuals associated reduced prejudice discrimination moreover greater acceptance support transgender people implications increasing acceptance transgender individuals discussed
doubt renewable sources solar energy played important role future renewable energy system solar heat great potential high contribution towards future energy supply directly collect fast convert efficiently store solar heat still problem solved solar energy application herein functional nanocomposite film designed fabricated toward efficient conversion storage solar thermal energy functional nanocomposite film feasibly prepared uniformly imbedding phase change materials pcms nanoparticles pva matrix uniformly hydrogen bonding interactions nanoparticles photothermal nanoabsorbers low concentration similar instantly intensely realize solar heat conversion utilizing surface plasmon resonance subsequently efficiently conversion heat could stored pcms film interior reversible phase transformation meanwhile leakage evaporation pcms observed due strong hydrogen bonding confinement interface pcms film matrix kind functional nanocomposite films great importance wide usage fields solar thermal energy conversion storage thermal interface materials protective layers sensing etc
present new efficient data structures elements coxeter groups type associated iwahori hecke algebras usually elements represented simple coefficient list length respect standard basis indexed elements coxeter group new data structure elements represented nested coefficient lists cost addition data structures new data structure leads huge improvement cost multiplication elsevier ltd rights reserved
objectives determine incidence hypogonadism men human immunodeficiency virus hiv acquired immunodeficiency virus aids useful serum testosterone measurement threshold diagnosing hypogonadism comparative efficacy testosterone replacement therapy trt gels androgel abbott laboratories testim auxilium pharmaceuticals inc design subjects stage observational study stage patient records medical practices specializing hiv aids reviewed eligible patients aged years hiv seropositive status confirmed enzyme linked immunosorbent assay western blot test hiv viremia confirmed hiv rna polymerase chain reaction prior baseline testosterone assessments hypogonadism presence signs symptoms hypogonadism well total testosterone free testosterone level measurements stage included evaluation patients stage treated day trt stage inclusion criteria diagnosis low testosterone defined level level per endocrine society guidelines presence absence hypogonadal signs symptoms months evaluable sign symptom assessments level measurements trt either testim androgel weeks initial trt initial trt switched discontinued results four hundred one patients met stage inclusion criteria patients androgel testim met stage inclusion criteria total testosterone level alone identified patients hypogonadal failed diagnose additional patients levels hypogonadal symptoms month androgel increased mean levels levels compared respectively testim patients treated testim showed significantly greater improvements libido sexual performance nighttime energy focus concentration abdominal girth trends greater improvement fatigue erectile dysfunction patients treated androgel patients discontinued therapy due adverse events conclusion useful serum testosterone measurement threshold diagnosing hypogonadism men hiv aids level hypogonadal symptom currently accepted thresholds criteria using level level diagnosed patients respectively hypogonadism testim effective androgel increasing levels improving hypogonadal symptoms
objective coverage high school football orthopedic sports medicine specialists considered standard care many localities determining economic viability endeavor never investigated primary purpose present investigation perform economic analysis local high school sports coverage orthopedic sports medicine practice methods january june prospective injury report database used collect sports injuries five high school athletic programs covered single private orthopedic sports medicine practice patients referred orthopedic care tracked determine expected cost care potential revenue evaluation management codes current procedure terminology codes obtained determine value physician visits surgical care rendered overhead costs calculated based historical rates within practice incorporated determine estimated profit results athletic trainer contacts athletes playing sports including field training room resulted physician referrals covering orthopedic practice handled orthopedic referrals orthopedic physician referrals required orthopedic surgical treatment covering team practice handled surgical cases total revenue collected covering team practice overhead cost treatment overall estimated profit orthopedic visits treatment period covering practice conclusions covering team practice handled orthopedic referrals surgical cases captured potential profit increase physician referrals could increase benefit orthopedic surgeons
paper presents new method dynamic compensation load cell response using linear time varying continuous time filter load cells oscillatory response always needs time settle therefore justified search technique effective improvement sensor response paper describes theoretical implementation proposed time varying filter suggests implementation technique aid kind filter implemented practice simulation results verifying effectiveness proposed filter presented compared traditional time invariant configuration elsevier ltd rights reserved
objective evaluate efficacy intensive outpatient program designed improve functioning reduce psychological impairment chronic headache patients background chronic headaches occurring days per month three months may arise multiple international classification headache disorders diagnoses chronic migraine chronic tension type headache new daily persistent headache chronic post traumatic headaches medication overuse headache several interdisciplinary programs treat patients chronic headaches reported decreases headache frequency study sought evaluate effect week interdisciplinary treatment program patients chronic headache disorders headache severity functional status psychological impairment methods subjects patients admitted outpatient chronic headache treatment program assessments headache severity psychological status functional impairment completed time admission discharge subjects provided assessment data provided data year follow results subjects mean ratings scale headache pain prior week declined improvements maintained follow estimated marginal means scale average pain admission discharge follow least pain admission discharge follow worst pain admission discharge follow similar results found current pain admission discharge follow measures functional impairment also improved following treatment gains maintained month follow estimated marginal mean headache impact test score admission discharge follow estimated marginal mean pain disability index score admission discharge follow measured depression anxiety stress scale anxiety reactivity stress decreased following treatment remained improved follow estimated marginal mean score anxiety admission discharge follow estimated marginal mean score stress admission discharge follow depression decreased treatment year follow depression scores remained significantly lower admission also significantly higher discharge estimated marginal means admission discharge follow conclusions study supports efficacy treatment model limitations study suggestions future research also discussed
background although efficacy safety smoking cessation interventions well established efficacy safety patients cardiovascular disease cvd remain unclear objective study evaluate efficacy safety pharmacological behavioral smoking cessation interventions cvd patients via meta analysis randomized controlled trials methods results embase psycinfo medline pubmed cochrane tobacco addiction specialized register searched randomized controlled trials evaluating efficacy smoking cessation pharmacotherapies behavioral therapies cvd patients outcomes interest smoking abstinence months defined using rigorous criteria reported data pooled across studies direct comparisons using random effects models network meta analysis using graph theoretical approach used generate indirect comparisons seven pharmacotherapy randomized controlled trials behavioral intervention randomized controlled trials met inclusion criteria network meta analysis revealed varenicline relative risk confidence interval bupropion associated greater abstinence placebo evidence nicotine replacement therapies inconclusive telephone therapy individual counseling efficacious usual care whereas hospital behavioral interventions conclusions meta analysis suggests varenicline bupropion well individual telephone counseling efficacious smoking cessation cvd patients
technique proposed design engineered reflectors consisting doubly periodic arrays printed thin grounded dielectric substrates reflect incoming wave given incoming direction predetermined outgoing direction proposed technique based combination floquet theory propagation periodic structures reflect array principles flat surface designed reflect polarized wave incident degrees back direction impinging signal ghz employed example means full wave simulations demonstrated monostatic rcs finite reflector comparable specular rcs metallic mirror dimensions shown comparably high monostatic rcs values obtained angles incidence degrees degrees range frequency dependent thus open opportunities target localization prototype array fabricated experimentally tested validation proposed solution used modify radar cross section target potential applications also discussed
bridal virginity retains undeniable value iran contemporary cultural landscape widely regarded sign chastity purity unmarried girls failure prove virginity wedding night may serious consequences girl context recent growth rate hymen restoration surgery hymenoplasty due increase number girls engage premarital sexual relationships present study attempts elucidate processes particular physical features come considered culturally meaningful explores phenomenon hymen reconstructing surgery perspective young tehrani girls boys applying anthropological insights gender roles explore called rebellious iranian girls find surgical reconstruction hymen means negotiate dominant models gender subjective experiences actions challenge premarital sex taboo iranian girls participate hymen restoration surgery also conform values require virgin time marriage thus reinforcing existing power relations
propose differential versioning based data storage divers architecture distributed storage systems relies novel erasure coding technique exploits sparsity across versions emphasis work demonstrate sparsity exploiting codes sec originally designed optimization extended significantly reduce storage overhead repository versioned data addition facilitating reduced storage address key reliability aspects divers mechanisms deploy coding technique arbitrarily varying size data across versions investigating right allocation strategy encoded blocks network distributed nodes across different versions achieve best fault tolerance also discuss system issues related management data structures accessing manipulating files differential versions elsevier rights reserved
brain network alterations patients alzheimer disease subject much investigation biological mechanisms underlying alterations remain poorly understood aim identify changes brain networks patients mild cognitive impairment mci provide accurate algorithm classification patients healthy control subjects using graph theoretical approach advanced machine learning methods multivariate granger causality analysis performed resting state functional magnetic resonance imaging fmri data mci calculate various directed graph measures graph measures used original feature set machine learning algorithm filter wrapper feature selection methods applied original feature set select optimal subset features accuracy achieved classification mci using optimal features naive bayes classifier also performed hub node analysis found number hubs mci respectively suggesting patients experience disturbance critical communication areas brain network progresses findings study provide insight neurophysiological mechanisms underlying mci proposed classification method highlights potential directed graph measures fmri data identification early stage elsevier rights reserved
post weaning feed restriction common practice rabbit farming reduce mortality results lower growth performance slaughter weights study aimed assess influence diets rich fibre low starch high low digestible energy digestible protein contents constant ratio offered age growth performance health parameters rabbits eight hundred rabbit kits divided experimental groups differing feed offered high concentrate diet group low concentrate diet group feed offered libitum weaning feed offered controlled obtain similar intake groups feed intake animal weights health status recorded weekly mortality recorded daily feed intake similar groups weaning consequently intake higher group compared group weaning respectively feed intake lower group kit respectively total ingested weaning similar groups kits heavier group throughout study higher average daily gain periods seen group respectively mortality morbidity rates similar groups throughout study respectively results suggest feed intake weaning controlled feeding strategy weaning determines weight weaning slaughter age rabbits fed diet highly concentrated rich fibre increase growth performance without negative consequences digestive health
many water related human interventions modify natural hydrological systems watersheds rainwater harvesting rwh intervention involves harnessing water water harvesting used upstream prevents surface runoff downstream impacting biodiversity ecosystems main objective study assess effects water harvesting technologies downstream water availability alaba district ethiopia soil water assessment tool swat model cost benefit ratio optimal control approach oca used analyze hydrological socioeconomic impact trade offs water availability community respectively downstream impact increasing water consumption upstream rainfed areas bilate shala watershed simulated using semi distributed swat model two land use scenarios tested sub basin levels conventional land use represent current land use practice agri con infield rainwater harvesting irwh improving soil water availability rwh land use scenario simulated water balance results showed highest peak mean monthly direct flow obtained agri con land use followed agri irwh land use agri irwh scenario reduced direct flow compared agri con groundwater flow contributed agri irwh agri con overall result suggests water yield area may negatively affected agri irwh land use scenario technology district benefited positively average cost benefit ratio storage tanks series check dams gravel filled dams alternative solutions water harvesting
environmental consideration within swedish construction sector longer considered marginal discussed whether commitment extended facilitate deeper dimensions sustainability provision housing beyond simply energy efficient residential buildings paper presents case multi family green residential area developed goteborg sweden interview study seven housing developers building area provides primary empirical insights complemented findings workshop architects involved project conceptualizations sustainability housing explored based discourses among market actors issues identified inductive data analysis relate ambitions set measures taken new green building well market perceptions housing standards lifestyles household configurations reproduced built environment paper shows interpretations sustainability market led housing development radically challenge normative resource intense contemporary ideals surrounding urban home realization goals undertaken case kvillebacken generally dependent economic considerations market assessments conclusion paper emphasizes need formulate integrative approach holistic sustainable residential environments
objective although reducing pain catastrophizing shown contribute functional improvement patients receiving interdisciplinary pain care little known changes different dimensions pain catastrophizing uniquely contribute improvement outcome study examined unique relationship changes distinct factors pain catastrophizinghelplessness rumination magnificationand changes pain outcomes materials methods nonrandomized study patients completed treatment week interdisciplinary pain rehabilitation program years completed battery psychometrically validated measures pain catastrophizing pain severity pain interference mental physical health related quality life depressive symptoms pretreatment posttreatment results series within groups repeated measures mediation analyses conducted change helplessness rumination magnification subscales entered multiple mediators model analyses revealed change helplessness partially mediated improvement outcome variables beyond influence change variables model whereas change rumination partially mediated improvement pain severity interference depressive symptoms change magnification least impact outcome partially mediating improvements mental health quality life discussion results suggest changes dimensions pain catastrophizing differentially mediate improvement pain outcome treatment approaches specifically target helplessness rumination may particularly useful improving outcomes patients refractory pain conditions enrolled interdisciplinary pain rehabilitation program
nosql also called non relational sql database system provides approach data management database design large sets distributed data real time web applications nosql database system also popular data storage information retrieval supports better scalability availability faster data access comparing traditional relational database management systems rdbms rdbms data needs predictable data stored structured tables defining relationship different columns contrary data nosql databases need stored structured fixed fashion performance realtime access concerned consistency indexing retrieving large numbers records nosql databases suitable relational databases obvious advantages better performance scalability flexibility nosql databases adopted lately many small businesses moving increasing business data clouds however research security specific nosql database system nosql database systems general limited although many storage advantages nosql databases need quick easy access data seriously affected security issue nosql databases paper examines maturity security measures mongodb typical nosql database system aspects attack defense code level experimental testing nosql injections performed javascript php demonstration server side javascript injection attack nosql database system reveals customer private data two methods discussed preventing type security problems happening believed study help database developers realizing nosql database systems designed security priority also learning build security layer organizations nosql applications avoid nosql injections
variability solar energy grid systems dictates sizing energy storage systems along sizing scheduling loads present grid system unfortunately energy storage may costly frequent switching loads absence energy storage system causes wear tear avoided yet amount solar energy utilized maximized problem finding optimal static load size finite number discrete electric loads basis load response optimization considered paper objective optimization maximize solar energy utilization without need costly energy storage systems grid system conceptual real data solar photovoltaic power production provides power input grid system given number units following analytical solutions computational algorithms proposed compute optimal load size unit mixed integer linear programming constrained least squares based available solar power profile algorithms select optimal switch times maximize solar energy utilization computing optimal static load sizes effectiveness algorithms compared using one year solar power data san diego california thuwal saudi arabia shown annual system solar energy utilization optimized using two loads boosted using six load configuration elsevier ltd rights reserved
study aims compare vitro fitting accuracy implant supported metal frameworks used full arch orthodontic restoration hypotheses tested follows fixed implant morphology strains developed within framework depend framework fabricated stresses transferred implant bone interface related amount framework misfit metal frameworks fabricated using four different manufacturing techniques conventional lost wax casting resin cement luting electrospark erosion computer aided design computer aided manufacturing milling framework instrumented three strain gauges measure strains developed prosthetic misfit quantitative photoelastic analysis used assess effect misfit implant resin interface tested frameworks presented stress polarization around fixtures screw tightening significantly greater strains observed lost wax superstructure lowest strains observed luted framework demonstrating consistent adaptation passive fitting significant difference stress distribution marginal fit found bars fabricated either computer aided design computer aided manufacturing spark erosion study suggested spite known limitations vitro testing direct luting mesostructures abutments first clinical option treatment complete edentulism ensuring consistent passive fitting effective cost benefit ratio
aim plasmid isolated aeromonas dhakensis strain understand function host main objective study isolate sequence plasmid predict genes proteins encoded experimentally prove biochemical function methodology aeromonas dhakensis strain plasmid sequenced next generation sequencing ngs illumina miseq platform bioinformatics analysis carried predict putative gene encoded protein functions nspv like endonuclease recombinantly expressed escherichia coli partially purified characterized activity plasmid substrates results plasmid sequencing bioinformatics analysis predicted presence nspv like endonuclease recombinant expression purification characterization nspv like endonuclease revealed nicking endonuclease activity protein plasmid substrates interpretation nspv like endonuclease described study dna nicking activity study would help understanding better survival aeromonas ecosystem role host plamids
multifunction systems operate different functions like radar communication electronic warfare offer variety benefits beyond well known aesa active electronically steerable antenna features reach sufficient technology maturity start product development series challenges stemming large required operation bandwidth resolved dual polarised low loss apertures array grids designed grating lobe scan blindness free conical field view fov highest operational frequency considered active components aesa especially required power efficient whole multifunction bandwidth shall miniaturised fit array grid functions like high speed datalink require linear high power amplification low harmonics generation interference suppression receive essential order maintain performance enablers broadband aesa gan technology front end components sige bicmos technology core chip digital control paper shows state art technology europe multifunction systems
slow eye movements sems sleep onset relationship vegetative rhythms investigated six healthy sleep deprived subjects yielding sems epoch min per experiment exclusively sleep stages recorded bandpass filtered electro oculogram eog signal cut frequencies turning points gaze detected compared start inspiration discriminated abdominal respiratory excursions sem cycle times varied considerably respiratory cycle times levene test preferentially equal length subjects ordination cross correlation histograms yielded inspiration sems also temporally ordinated thus temporal coherence regarding occurrence cycle time phase sems respiratory like rhythm findings show exactly respiratory rhythm mirrored sems rather favour interpretation autorhythmicity temporarily connected common brainstem system reticular formation brainstem
social influence exerted role modeling collective action impact social change contexts conducive collective action long lasting violent conflicts examined question two field experiments eastern democratic republic congo created two versions episode existing media intervention show aiming promote positive social change fictional characters either planned collective action role modeling condition plan action control condition address grievances study role modeling affected individual level outcomes increased perceived collective efficacy willingness take action exacerbated intergroup attitudes reduced tolerance study tested influence role modeling group level outcome group discussions discussions following role modeling show focused less grievances included positive lessons show well statements collective efficacy collective action findings highlight influence role modeling collective action media efficacy action social change caution unintended consequences intergroup attitudes elsevier inc rights reserved
acquired pendular nystagmus comprised quasi sinusoidal oscillations eyes significantly affecting gaze holding clarity vision common causes acquired pendular nystagmus include demyelinating disorders multiple sclerosis syndrome ocular palatal tremor however several deficits pharmacological intoxication metabolic genetic disorders granulomatous disorders lead syndromes mimicking acquired pendular nystagmus study kinematic features acquired pendular nystagmus suggested putative pathophysiology otherwise mysterious neurological disorder review clinical features neurological deficits occur acquired pendular nystagmus subsequent discussion pathophysiology individual forms pendular nystagmus speculates mechanisms underlying disease providing insights pharmacotherapy nystagmus elsevier rights reserved
background risk injury associated american football significant recent reports indicating football one highest rates cause injury including concussion major sports limited studies examining risk factors injuries national football league nfl purpose identify risk factors nfl concussions musculoskeletal injuries study design case control study level evidence methods injury report data collected prospectively week regular seasons teams poisson regression models used identify relationship predetermined variables risk frequent injuries knee ankle hamstring shoulder concussion results total games team games tgs regular seasons included study trend increasing risk concussion ankle injury decreasing mean game day temperature observed risk concussion incidence rate ratio irr ankle injury irr significantly greater tgs played mean game day temperature degrees degrees compared mean game day temperature degrees degrees risk shoulder injury significantly increased tgs played grass surfaces irr compared synthetic surfaces risk injury associated time season altitude time zone change prior game distance traveled game conclusion study evaluated extrinsic risk factors injury nfl hazardous association identified risk concussion ankle injury colder game day temperature research conducted substantiate relationship potential implication injury prevention initiatives
today development information communications technologies changed utility landscape dramatically particular electricity distribution networks rely heavily multitude intelligent systems devices communicate among much advanced ways past smart grid becoming nowadays critical component electricity delivery system important make sure grid equipped adequate security mechanisms able guarantee reliable operation real time information exchange within power infrastructure therefore paper analyze critical cybersecurity aspects associated smart grid services including previous cyber attack cases smart grids potential vulnerabilities threats advanced cybersecurity strategies smart grids technical management measures ultimately service providers continuously enhance traditional security measures authentication access control authorization data encryption public key infrastructure pki firewalls log analysis intrusion detection systems network security protocols propose advanced technical measures make smart grids survivable even cyber attacks internal failures employ defense depth approach employ defense depth approach provide scalable security measures furthermore also propose advanced management measures establish cybersecurity governance strategy develop strong incident response plan cultivate culture security employ public private partnership approach comply widely recognized security standards
surface water risk marcellus shale operations chemical storage drill pads hydraulic fracturing operations return water high total dissolved solids shale gas production research evaluated two commercial shelf water quality sensors responded simulated surface water pollution events associated marcellus shale development first peak concentrations contaminants typical spill events monitored watersheds estimated using regression techniques laboratory measurements conducted determine standard stream instrumentation monitor conductivity temperature dissolved oxygen responded three potential spill materials ethylene glycol corrosion inhibitor drilling mud produced water solutions ranging ppm spill material assessed range specific conductivity increased average drilling mud ethylene glycol produced water respectively average minor changes dissolved oxygen ppm observed continuous monitoring may part strategy detecting spills surface water minor impacts water quality highlight difficulty detecting spill events practical sensors placed mouths small watersheds drilling activities spill risks present contaminant travel distance strongly affects concentrations surface water systems
unique cogeneration system integrating biogas fed solid oxide fuel cell sofc concentrating solar thermal cst system reference waste water treatment plant wwtp italy proposed biogas locally wwtp anaerobic digestion collected sludge used produce electricity using sofc power modules thermal power recovered sofc exhaust stream used meet part digester thermal load however rest heat loads provided using integration cst system auxiliary boiler energy analysis performed determine effect using solar heating system system performance also economic performance evaluated cash flow analysis calculation levelized cost electricity lcoe observed installing solar collectors could cover total digester heat load respectively results show overall beneficial effect solar installation energy economic standpoint view scenarios analyzed lcoe lower grid electricity price increasing solar integration value reduced showing despite investment return time electricity production entire system lifetime competitive grid electricity prices elsevier ltd rights reserved
objective goal study determine core competencies means systematic literature review design test interpreter training program methods core competencies medical interpreting searched using systematic literature review intervention program developed improve core competencies pretests posttests conducted pilot test knowledge interpreting skills participants aged years results tests compared results results systematic review indicated five core competencies maintaining accuracy completeness medical terminology understanding human body behaving ethically making ethical decisions nonverbal communication skills cross cultural communication skills statistical analysis showed significant improvement knowledge interpreting skills intervention program compared control program conclusion posttest assessment showed developed training system useful improving knowledge quality medical interpreting practice implications day training program medical interpreters could bridge gap medical professionals patients limited english proficiency amenable integration clinical flow elsevier ireland ltd rights reserved
polycythemia vera myeloproliferative disorder characterized excess red cell clonality increased number red blood cells lead increased viscosity blood ultimately compromise blood supply end organs thromboembolic hemorrhagic complications also develop patients presenting neurological diseases require surgical intervention increased risk due various factors immobility prolonged surgical time hypothermia dehydration report anesthetic management patient underwent neurosurgical intervention vestibular schwannoma excision
classic bcr abl negative mpn operational sub category mpn includes polycythemia vera essential thrombocythemia primary myelofibrosis pmf harboring jakvf common mutation jakvf detected patients remaining patients carry somatic mutation jak exon approximately one third patients pmf carry mutation jak mpl december mutations described calreticulin calr gene jakvf mpl negative patients pmf respectively since discovery calr mutations reported mutually exclusive jakvf mpl mutations however recently studies eleven published reports reported coexistence jakvf calr mpn present study reporting jakvf positive patient center coexisting calr exon mutation type del ddel never reported coexisting mutation describing detail clinical outcomes
previous research shows inconsistency clinician assigned diagnoses autism spectrum disorder asd conducted exploratory study examined concordance diagnoses multidisciplinary assessment team range independent clinicians throughout australia nine video taped autism diagnostic observation schedule ados assessments collected two australian sites twenty seven australian health professionals observed two video recordings rated degree individual met dsm criteria asd agreement diagnostic classification video clips remaining clips reaching poor reliability addition participating clinicians achieved good excellent levels agreement cohen kappa original asd assessment findings implications clinical guidelines asd assessments
paper presented novel operational amplifier amp solution processed type amorphous indium gallium zinc oxide igzo thin film transistors tfts igzo tfts common source amplifier fabricated glass substrate solution process confirmed show stable electrical characteristics suitable display driving circuits based experimental results designed amp overall gain cut frequency khz unit gain frequency khz supply voltage finally constituting comparator proposed amp expected used power control driving systems display applications
background mutations calreticulin calr reported key markers molecular diagnosis myeloid proliferative neoplasms previous reports calr mutations analyzed using sanger sequencing report new rapid convenient system screening calr mutations without sequencing methods eighty three bone marrow samples obtained patients thrombocytosis pcr primers designed detect wild type calr product calr type product type mutations product one reaction results confirmed sanger sequencing compared results fragment analysis results minimum detection limit screening pcr type type cases mutations calr type type mutants detected screening pcr maximal analytical sensitivity respectively screening pcr detected mutation cases showed concordant results sequencing cases type type mutations sanger sequencing identified one novel mutation delinstgc compared sequencing screening pcr showed sensitivity specificity positive predictive value negative predictive value compared fragment analysis screening pcr presented sensitivity specificity conclusions screening pcr rapid sensitive cost effective method detection major calr mutations
study aims assessing technical economic benefits refurbishing existing public housing villas uae four representative federal public housing villas built modeled analyzed integrated environmental solutions virtual environment ies energy modeling software used estimate energy consumption savings due different refurbishment configurations applied villas refurbishment technical configurations based uae estidama green buildings sustainability assessment system refurbishment configurations include upgrading three elements wall roof insulation well replacing glazing annual electricity savings results indicated cost efficient refurbishment strategy upgrading wall insulation savings followed upgrading roof insulation savings lastly replacing glazing savings three elements refurbished simultaneously savings achieved villa model savings translated emission reduction year simple discounted payback periods different configurations tested ranged years respectively
industrial manufacturing engineering ime technical communication first year technical communication course designed first year college engineering applied sciences ceas students western michigan university wmu course meets university general education writing proficiency one requirement part core pre engineering pre engineering technology program beginning discussions amongst stem faculty best aid student retention meeting course outcomes course coordinator instituted series changes course syllabus requirements including emphasis career exploration development research writing lifelong learning awareness ime also become anchor course step stem talent enhancement program learning communities interaction faculty programs emphasizing early intervention academic etiquette contributing positively increase first year student retention rates
field psychology topic everyday life specific subject inquiry afforded little attention indeed everyday life recently analyzed mainly psychological studies examine people ways behaving thinking act situations termed mundane ordinary studies mainly carried two fields social psychology refer general terms social cognition social representation theory aim paper examine fields treat features commonly attributed everyday life particular features familiarization continuity stability time automaticity discussed order try figure meeting points two fields mentioned
metallurgical processes traditionally taught extractive metallurgy various metals years ago field process metallurgy advanced via special attention given analysis design metallurgical processes basis understanding controlling governing transport phenomena kinetics paradigm served well graduates metallurgical engineering programs countries strong metals producing industries like canada past years however witnessed total transformation metallurgy programs materials science engineering programs design production new advanced materials basis processing structure property performance relationships became new paradigm new context teaching research extraction processing discussed article written occasion ralph lloyd harris memorial symposium
person perception dynamic evolving process people endless source social information people need update impressions others based upon new information devised fmri study identify brain regions involved updating impressions participants saw faces paired valenced behavioral information asked form impressions individuals face seen five times row time different behavioral description critically half faces behaviors evaluatively consistent half inconsistent line prior work dorsomedial prefrontal cortex dmpfc associated forming impressions individuals based behavioral information importantly whole brain analysis revealed network regions associated updating impressions individuals exhibited evaluatively inconsistent behaviors including rostrolateral pfc superior temporal sulcus right inferior parietal lobule posterior cingulate cortex
spontaneous helping behavior emergency influenced personality onlooker social situational factors presence bystanders sought determine influences sympathy oriented response personal distress self oriented response effect bystanders emergency four experiments investigated whether trait levels sympathy personal distress predicted responses emergency presence bystanders using behavioral measures single pulse transcranial magnetic stimulation sympathy personal distress expected associated faster responses emergency without bystanders present personal distress would predict slower responses emergency bystanders present results cued reaction time task showed people reported higher levels personal distress sympathy responded faster emergency without bystanders exp contrast predictions perspective taking personal distress associated slower reaction times number bystanders increased emergency exp however decrease motor corticospinal excitability direct physiological measure action preparation increase number bystanders solely predicted personal distress exp incorporating cognitive load manipulations observation emergency suggested personal distress linked effect bystanders reflexive responding emergency exp taken together results indicate presence bystanders emergency reduces action preparation people disposition experience personal distress
multipoint eavesdropping attack elastic optical networks new objective criterion security strategy extended routing spectrum allocation algorithm proposed simulation results shows better security guarantee resource utilization provided
objectives doses drugs determined population level information resulting standard one size fits dose range individuals review explores doses personalised use individuals pharmacokinetic pharmacodynamic profile particular application children therapy areas approaches made inroads key findings bayesian forecasting approach based population models account variability exposure response potent method personalising drug therapy potential utility even greater young children additional sources variability observed maturation eliminating enzymes organs benefits personalised dosing easily demonstrated drugs narrow therapeutic ranges antibiotics cytotoxics limited studies shown improved outcomes however variety reasons approach struggled make widespread impact bedside complex dosing algorithms high level technical skills required lack randomised controlled clinical trials need regulatory approval summary personalised dosing necessary corollary new precision medicine initiative however faces number challenges need overcome approach dosing children becomes norm
conventionally high accuracy operational amplifier opa based current sensor used sensing current message full load range increases cost characteristic instead high accuracy opa based current sensor paper describes using switching inductor quasi hysteretic control boost regulator proposed current sensing technique named emulated ramp feedback erf improve transfer efficiency full load range two control systems presented paper first system hysteretic voltage control switching boost converter erf achieves hysteretic voltage control boost regulator lowers cost characteristic without using compensator second system quasi hysteretic voltage control switching boost converter erf demonstrates compatibility erf technique rippled based control boost converters regulator implemented tsmc cmos process experimental results show second system work specification load range additionally system attained recovery time step step continuous conduction mode load current peak efficiency chip area copyright john wiley sons ltd
introduction review aims evaluate current evidence efficacy acupuncture management overactive bladder methods fourteen databases searched inception including pubmed medline amed embase cochrane library six korean medical databases korean studies information service system dbpia korean institute science technology information research information service system koreamed korean national assembly library china national knowledge infrastructure cnki chongqing vip chinese science technology periodical vip wanfang randomized clinical trials using acupuncture without electrical stimulation overactive bladder considered selection studies data extraction assessment performed independently two researchers risk bias assessed cochrane risk bias dissemination systematic review published peer reviewed journal review also disseminated electronically print updates review conducted inform guide healthcare practice policy author published elsevier gmbh
using cardiovascular disease cvd risk instead addition blood pressure guide antihypertensive treatment active area research purpose review provide overview studies could inform treatment paradigm review data randomized trials relative absolute cvd risk reduction occur antihypertensive treatment guided cvd risk also review population level data using cvd risk conjunction guide antihypertensive treatment broad distribution cvd risk people similar levels use cvd risk guiding antihypertensive treatment among subgroups including older adults young adults diabetes mellitus chronic kidney disease addition review potential challenges implementing antihypertensive treatment recommendations incorporate cvd risk closing provide recommendations using cvd risk combination guide antihypertensive treatment american college cardiology foundation
review focuses research literatures published relating topics thermal effects water pollution control review divided following sections biological nitrogen phosphorus removal wastewater treatment organic conversion industrial wastewater treatment anaerobic digestion sewage sludge solid waste sludge biochar preparation application pyrolysis sewage sludge reduction heavy metal sewage sludge soil issues wastewater sludge treatment
background aberrant activation fibroblast growth factor receptor fgfr frequently observed bladder cancer involved carcinogenesis well understood current study aimed investigate underlying mechanism progression bladder cancer methods gse dataset downloaded gene expression omnibus used identify differentially expressed genes degs bladder cancer cell line without depletion fgfr gene ontology enrichment analysis performed fgfr centered protein protein interaction ppi regulatory networks constructed combined data retrieved gse prognostic makers bladder cancer predicted results identified total degs associated blood vessel morphogenesis cell division addition kiaa pola fgfr epha hub genes high degree fgfr centered ppi network besides micrornas mirnas transcriptional factors tfs predicted regulators nodes ppi network moreover cstf pola hmox efnb may associated prognosis bladder cancer patient conclusions current study may provide insights molecular mechanism fgfr mediator bladder cancer
energy recovery waste one strategies assist expansion renewable energy brazil among various types waste vinasse residue contains high organic load originates sugarcane industry important industry brazilian economy due high levels sugarcane harvesting country production large amounts ethanol vinasse produced high levels brazil context paper presents energy analysis avoided carbon dioxide emissions economic viability associated combustion biogas produced anaerobic digestion vinasse results use sugar cane planted brazil based literature review data related process biogas production anaerobic digestion vinasse collected used calculation energy potential associated results show achieve economic viability use waste energy following plantation areas would required considering processed sugarcane equivalents considering processing sugarcane attached plants considering processing sugarcane autonomous plants total energy potential use may reach twh represents domestic energy consumption potential avoid emissions use could reach approximately emissions whole industry brazil results demonstrate environmental energy benefits obtained via power generation biogas produced anaerobic digestion vinasse highlight need include use residue energy expansion plans brazilian energy matrix elsevier ltd rights reserved
following dominant firm competitive fringe model paper analyses response japan nonrenewable electricity utilities renewable portfolio standards rps feed tariff fit scheme output electricity renewable energy sources res primarily correlated magnitude rps requirement fixed tariff nonrenewable firms suffer reduction revenue due increased res production schemes rps requirement direct impact renewable energy certificate nec price incumbent nonrenewable electricity utilities gain market power electricity nec markets suppress rps quota preserve vested benefits fit scheme market res generation cost passed consumers via surcharge since grid connected res accelerated rapidly fit nonrenewable electricity utilities would face substantial increase costs maintain network reliability due intermittent variable nature res technologies japanese government therefore take measures ensure variable renewable power occupies higher share electricity system cost effective manner elsevier ltd rights reserved
background non hiv aids related diseases gaining prominence important causes morbidity mortality among people living hiv purpose study characterize compare changes time mortality rates causes death among population based cohort persons living without hiv british columbia canada methods analysed data comparative outcomes service utilization trends coast study retrospective population based study created via linkage centre excellence hiv aids population data containing data hiv infected individuals general population respectively analysis included known hiv infected adults years random sample uninfected adults followed deaths identified population data contains information registered deaths vital statistics agency dataset classified cause death categories using international classification diseases icd codes age standardized mortality rates asmr mortality rate ratios calculated trend test performed results individuals died person years follow among hiv infected uninfected individuals respectively cause cause specific mortality rates consistently higher among hiv infected compared hiv negative individuals except neurological disorders cause asmr decreased per population decline trend compared change among uninfected individuals decline mortality rates hiv aids related causes decreased per population era significant asmr reductions also observed hepatic liver disease drug abuse overdose deaths asmrs neurological disorders increased significantly time non aids defining cancers currently leading non hiv aids related cause death hiv infected uninfected individuals conclusions despite significant mortality rate reductions observed among hiv infected individuals still excess mortality risk compared uninfected individuals additional efforts needed promote effective risk factor management appropriate screening measures among people living hiv
intrusion detection essential part network security combating illegal network access malicious attacks due constantly evolving nature network attacks technical challenge intrusion detection system ids recognize unknown attacks known attacks inadequate training data work innovative fuzzy classifier proposed effectively detecting unknown attacks known attacks insufficient inaccurate training information fuzzy means fcm algorithm firstly employed softly compute optimise clustering centers training datasets degree fuzziness counting inaccuracy ambiguity training data subsequently distance weighted nearest neighbors classifier combined dempster shafer theory dst introduced assess belief functions pignistic probabilities incoming data associated known classes finally two stage intrusion detection scheme implemented based obtained pignistic probabilities entropy function determine input data normal one known attacks unknown attack proposed intrusion detection algorithm evaluated application kdd datasets variants containing known unknown attacks experimental results show new algorithm outperforms intrusion detection algorithms especially effective detecting unknown attacks
background peri orbital dark circles cosmetic concern worldwide attributed hyperpigmentation allergy atopic dermatitis blood stasis structural shadowing effects thin epidermis dermis eye interest better understand lifestyle demographic risk factors relative impact melanin blood epidermal dermal factors severity peri orbital dark circles objective compare non invasive imaging impact biological factors visual grading scale peri orbital dark circles test correlation various demographic factors peri orbital dark circles methods subjects completed lifestyle health survey peri orbital dark circles severity evaluated using standardized photographs hyperspectral image analysis used assess contributions melanin blood volume degree blood oxygen saturation dermal scattering results family history significant risk factor peri orbital dark circles average age onset years earlier onset correlated higher severity scores asthma significantly associated peri orbital dark circles scores self reported allergy study sleep correlated peri orbital dark circles scores hyperspectral imaging indicated melanin dominant correlate peri orbital dark circles severity oxygen saturation secondary difference eye cheek measurements delta delta significant instrumental parameters correlated visual assessment peri orbital dark circles severity conclusion although typically associated lack sleep risk peri orbital dark circles primarily hereditary main factors contributing appearance peri orbital dark circles melanin deoxygenated blood
spinal cord stimulators scs well recognised treatment modality management number chronic neuropathic pain conditions particularly failed back syndrome radiculopathies implantable pulse generator ipg component scs designed operates similar fashion cardiac pacemaker ipg consists electrical generator lithium battery transmitter receiver minicomputer stimulated generates pulsed electrical signals stimulate dorsal columns spinal cord thus alleviating pain analogous cardiac pacemaker potentially damaged ionising radiation linear accelerator patients undergoing radiotherapy herein report clinical management first reported case patient requiring adjuvant breast radiotherapy scs situ also provide useful practical recommendations management scenario within radiation oncology department
schottky diode based doublers crucial elements room temperature high spectral resolution terahertz heterodyne receiver planetary science remote sensing discrete schottky diode based terahertz doubler acts receiver working ghz range presented measured performance essentially agreement predictions linear nonlinear simulations methodology practicability discrete planar gaas schottky diodes based frequency doubler design wiley periodicals inc microwave opt technol lett
paper presents application microwave near field technique ultra ductile material known engineered cementitious composite ecc civil materials engineering goal interdisciplinary research develop correlation strengths microwave properties simple yet accurate models developed monitor strength evolution thus predict final strength ecc means microwave conductance
present study aimed test hypothesis testosterone deprivation impairs osteoblastic insulin signaling decreases osteoblast survival reduces bone density obesity aggravates deleterious effects testosterone deprived rats twenty four male wistar rats underwent either bilateral orchiectomy sham operation rats group divided two subgroups fed either normal diet high fat diet weeks end protocol blood samples collected determine metabolic parameters osteocalcin ratios tibiae collected determine bone mass using microcomputed tomography osteoblast isolation results showed rats fed sham operated fed rats hfs orx fed rats hfo developed peripheral insulin resistance decreased trabecular bone density fed rats orx fed rats ndo group decreased trabecular bone density addition osteoblastic insulin resistance indicated decrease tyrosine phosphorylation insulin receptor akt observed groups except sham operated fed rats nds rats groups exception nds rats also decreased osteoblastic survival differences levels osteoblastic insulin resistance osteoblastic survival found among ndo hfs hfo groups findings suggest either testosterone deprivation obesity alone impair osteoblastic insulin signaling decrease osteoblastic survival leading development osteoporosis however obesity aggravate deleterious effects bone testosterone deprived rats
paper programmable input mode instrumentation amplifier utilising second generation multiple output current conveyors transmission gates presented main advantage ability choose voltage current mode inputs setting voltage two configuration nodes presented prepared integrated circuit block used alone sub block microcontroller field programmable gate array fpga shall condition analogue signals next converted analogue digital converter adc designed ams cmos technology power supply power consumption approximately linear input range voltage mode reaches current mode passband mhz amplifier works class current supply almost constant cause noise disturbing nearby working precision analogue circuits
aim investigate impact inflammatory bowel disease ibd alpha heremans schmid glycoprotein ahsg fetuin potential associations disease patient characteristics methods ahsg serum levels determined treatment naive newly diagnosed patients ulcerative colitis crohn disease diarrheapredominant mixed irritable bowel syndrome ibs types healthy controls enzyme linked immunosorbent assay elisa patients followed minimum period years gastroenterology department university hospital larissa greece reactive protein crp anti glycan antibodies anti saccharomyces cerevisiae mannan antibodies igg anti mannobioside carbohydrate antibodies igg anti laminariobioside carbohydrate antibodies igg anti chitobioside carbohydrate antibodies iga also determined via immunonephelometry elisa respectively results mean serum ahsg following adjustment confounders ibd patients significantly lower ibs patients cases ahsg levels comparable groups based ahsg levels ibd patients could distinguished sensitivity specificity adjusted analysis verified inverse association ahsg penetrating well stricturing partial correlation coefficient respectively adjusting confounding factors inverse correlations ahsg crp need anti tnf alpha therapy surgery found partial correlation coefficients respectively cases finally ibd individuals seropositive least one marker ahsg levels falling within two lower quartiles least two serological markers positive exhibited ahsg concentrations within lowest quartile adjusting age sex smoking conclusion ahsg used distinguish ibd ibs patients time predicting complicated disease behavior need therapy escalation surgery moreover ahsg may offer new insights pathogenesis ibd since involved key processes
function robot living together converges problem communication focus nonverbal communication relationship service robots human show nonverbal communication experiments robot build relationship human described ideal fiction robots live got experience relationship based touch communication managed three elements appearance motion predictable behavior result elements based embodiment human touches robot feeling safe natural motion motivation build relationship robots decided three elements physically appearance motion important evaluation relationship complicated relationship grows depending spending time motivation relate experiences shown life sized humanoid robot robot arm exhibition based results evaluation method understand relationship robot human considered near future robot development
paper novel high gain amp design presented proposed circuit also exhibits high linearity architecture amp presented paper based cross coupled differential pair positive feedback proposed amp designed cmos process using umcnm library cadence virtuoso analog design environment simulation proposed circuit results gain mhz ugb degree phase margin dissipating power thd analysis circuit shows maximum distortion output peak peak voltage khz frequency
paper discusses implementation burnup dependent fuel thermal conductivity model within reactor dynamics fuel modeling group rdfmg version subchannel thermal hydraulics code cobra ctf model takes account degradation fuel thermal conductivity high burnups dependence gadolinium content uranium dioxide mox mixed oxide nuclear fuel rods modified nuclear fuel industries nfi model rods duriez modified nfi model mox rods incorporated ctf validate models fuel centerline temperatures predicted ctf compared halden reactor experimental data high fidelity frapcon calculations halden test cases fuel rods beginning life bol lifetime without gdo mox fuel rods simulated ctf demonstrated ctf new burnup dependent fuel thermal conductivity model predicts fuel centerline temperature less error compared halden measurements ctf calculations performed fifty eight data points statistical analyses dimensionless predicted measured fuel centerline temperature ratios confirmed advantage new model mean value predicted measured temperature ratios increased standard deviation decreased elsevier ltd rights reserved
data concerning occurrence emerging biological contaminants antibiotic resistance genes args fecal indicator bacteria fib aquatic environments sub saharan african countries limited hand antibiotic resistance remains worldwide problem may pose serious potential risks human animal health consequently growing number reports concerning prevalence dissemination contaminants various environmental compartments sediments provide opportunity reconstruct pollution history evaluate impacts study investigates abundance distribution toxic metals fib args released hospital effluent wastewaters presence river sediments receiving systems args tem bla ctx bia shv aada total bacterial load selected bacterial species fib escherichia coil enterococcus ent species psd quantified targeting species specific genes using quantitative pcr qpcr total dna extracted sediments recovered hospital outlet pipes hop river receiving systems city kinshasa democratic republic congo results highlight great concentration toxic metals hop reaching values results also highlight highest values rrna fib args copy numbers sampling sites including upstream control site discharge point downstream receiving rivers indicating hospital effluent water exclusive source biological contaminants entering urban rivers significant correlation observed analyzed args total bacterial load rrna args except bla tem fib psd iii args except bla tem toxic metals findings demonstrate several sources including hospital urban wastewaters contribute spread toxic metals biological emerging contaminants aquatic ecosystems
embedded real time software systems ess play important role almost every aspect daily lives rely functionally correct adhere timing constraints ensuring computational results always delivered time violations timing constraints safety critical ess airplane medical control device disastrous economic social consequences identifying correcting violations therefore important challenging research topic article address challenge describe rigorous approach timing analysis programs proving results precise practice important worst case execution time wcet ess maximal running time system specified hardware wcet analysis needs provide formal guarantee system meets timing constraints even worst case requires compute safe tight bound execution time program existing wcet tools however usually able guarantee feasible system trace takes indeed long stated computed execution time bound often due employed abstractions static analysis computed wcet bound overestimates actual wcet bound since loop bounds timing relevant program properties computation based computed spurious infeasible system traces ruled path sensitive program abstraction analyzing program resources article present approach inferring proving wcet bounds precise approach guarantees wcet bound computed feasible system trace achieved combining wcet computation path wise symbolic execution abstraction refinement loop way symbolic execution targeted limited relevant program parts thereby taming avoiding usually prohibitive computational costs symbolic execution full path coverage moreover approach improves quality underlying wcet analysis since automatically tightens bound proven precise thereby improving precision initially computed wcet bound overall approach anytime algorithm stopped time without violating soundness results run termination wcet bound proven precise automatically inferring additional constraints spurious traces using constraints abstraction refinement implemented approach tubound wcet tookhain tested challenging benchmarks wcet community experimental results underline advantage using symbolic methods proving wcet bounds precise moderate cost elsevier ltd rights reserved
purpose study analyze differences two running styles rear foot strike rfs heel lands first fore foot strike ffs ball foot lands heel comes running styles compared term vertical mathematical model parameters motion analyzed data ground reaction forces measured force platform subjects performing style running various velocities ranging unique set parameters model trial computed nonlinear programming minimize sum relative standard error ground reaction force relative error rebound velocity motion analyzed data measured high speed motion capture system differences running styles considered using results parameters multi degree freedom model motion analysis results study indicate ffs needs less energy rfs contact style impulse internal forces also indicates ratio upper lower mass vertical mathematical model higher ffs rfs previous study also showed effective mass related first peak ground reaction force smaller ffs rfs reason ffs may reduce risk running injuries injuries hip knee ankle joints reducing impact body authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
critical question brain development whether different brain circuits mature concurrently different timescales characterize anatomical functional development different visual cortical areas one must able distinguish areas show zinc histochemistry reveals subset glutamatergic processes used reliably distinguish visual areas juvenile adult ferret cerebral cortex postnatal decline levels synaptic zinc follows broadly similar developmental trajectory multiple areas ferret visual cortex zinc staining areas examined suprasylvian greater week old adult furthermore less laminar variation zinc staining week old visual cortex adult despite differences staining intensity areal boundaries discerned juvenile adult weeks age observe significant decline visual cortical synaptic zinc decline pronounced layer areas much less change higher order extrastriate areas important period visual cortical development following eye opening weeks age laminar pattern zinc staining visual areas essentially adultlike decline synaptic zinc supra infragranular layers areas proceeds rate though decline layer results suggest timecourse synaptic zinc decline lamina specific confirm extend notion least aspects cortical maturation follow similar developmental timecourse multiple areas postnatal decline synaptic zinc observe second postnatal month begins eye opening consistent evidence synaptic zinc regulated sensory experience
paper discussed challenges handling real time medical big data collection storage health information system based challenges proposed model real time analysis medical big data exemplify approach spark streaming apache kafka using processing health big data stream apache kafka works well transporting data among different systems relational databases apache hadoop non relational databases however apache kafka lacks analyzing stream spark streaming framework capability perform operations stream identified challenges current real time systems proposed solution cope medical big data streams
smart homes gained attraction several years people daily lives still increasing provide fruitful foundation creation social network services escort habits regular activities people home along way even work smart homes current development stage able support people intelligent functionality also predict behavior even interaction social network person smart home technology makes strong use big data techniques help master vast amount data generated continuously paper conduct literature research investigates current state art smart homes related generation social network services big data driven environment reveal future research opportunities emerge combination mastering big data smart homes hence provide design recommendations social network services
significant proportion labor force works irregular hours harvest summer holiday work surges unfortunately workers often uninformed importance sleep fatigue management seasonally timed worker training improve health safety outcomes work surges
cultural notions equating greater morality virtue hard work productive output deeply embedded american value systems exemplified people understand execute personal body projects including efforts become slim bariatric surgery commonly viewed low effort means losing weight individuals opt surgery often perceived cheating extended ethnographic study within one bariatric program southwestern united states shows patients conscientiously perform productivity prioritizing discourses focus hard work inherent value necessity surgery patients practitioners alike contest dominant public views surgically induced weight loss
numerous problems involving gradient driven transport processes fourier darcy law heterogeneous materials concern physical domain much larger scale coefficients vary spatially overcome prohibitive computational cost associated problems well established distributed microstructure model dmm provides two scale description transport process produces computationally cheap approximation fine scale solution achieved via introduction sparsely distributed micro cells together resolve small patches fine scale structure macroscopic equation effective coefficient describes global transport microscopic equation governs local transport within micro cell paper propose new formulation extended distributed microstructure model edmm macroscopic flux instead defined average microscopic fluxes within micro cells avoids need effective parameters accurately accounts non equilibrium field micro cells another important contribution work presentation new improved numerical scheme performing two scale computations using control volume krylov subspace parallel computing techniques numerical tests carried two challenging test problems heat conduction composite medium unsaturated water flow heterogeneous soils results indicate dmm efficient edmm accurate able capture additional fine scale features solution elsevier inc rights reserved
opencl specification tightly binds command queue specific device best performance user find ideal queue device mapping command queue creation time effort requires thorough understanding underlying device architectures kernels program paper propose add scheduling attributes opencl context command queue objects leveraged intelligent runtime scheduler automatically perform ideal queuedevice mapping proposed extensions enable average opencl programmer focus algorithm design rather scheduling automatically gain performance without sacrificing programmability example design implement opencl runtime task parallel workloads called multicl efficiently schedules command queues across devices case studies include snu benchmark suite real world seismology simulation benefit runtime optimizations users apply proposed scheduler extensions four source lines code average existing opencl applications evaluate single node multinode experiments also compare socl closest related work show multicl maps command queues optimal device set cases negligible runtime overhead elsevier rights reserved
isotactic polypropylene carbon black ipp long chain branched polypropylene carbon black lcbpp composite melts melt blending method solution process chosen paper know relationship rheological electrical percolation process learn evolution destruction rheological network rheological percolation threshold electrical percolation threshold ipp composites less rheological percolation threshold electrical percolation threshold lcbpp composites mainly attributed two kinds mechanisms governing electrical network rheological network agglomeration particles accelerated annealing elevated temperatures promotes self perfection rheological network strong interaction polar long chain branched structure filler also led reduced network lcbpp composites difficult broken network ipp composites solution process
idiopathic pulmonary fibrosis fibrosing interstitial pneumonia associated radiological histological pattern usual interstitial pneumonia aetiology unknown probably comprises action endogenous exogenous micro environmental factors subjects genetic predisposition diagnosis based presence characteristic findings high resolution computed tomography scans pulmonary biopsies absence interstitial lung diseases aetiologies clinical evolution variable although mean survival rate years clinical presentation patients idiopathic pulmonary fibrosis may present complications comorbidities modify disease clinical course prognosis mild moderate disease treatment consists administration anti fibrotic drugs severe disease best therapeutic option pulmonary transplantation paper review diagnostic therapeutic aspects disease elsevier espafia rights reserved
present large volumes information regularly produced world information unstructured lacking properties usually expected instance relational databases one interesting issues computer science possible may achieve data mining unstructured data intuitively analysis attempted devising schemes identify patterns trends means statistical pattern learning basic problem approach user decide priori model patterns furthermore way found data true regardless kind data textual musical financial otherwise paper explore alternative paradigm raw data categorized analyzing large corpus set categories different instances category determined resulting structured database instances mapped numerical value preserves underlying patterns done using genetic algorithm set multi layer perceptron networks every categorical instance replaced adequate numerical code resulting numerical database may tackled usual clustering algorithms hypothesize unstructured data set may approached fashion work exemplify textual database apply method characterize texts different authors present experimental evidence resulting databases yield clustering results permit authorship identification raw textual data
survival transformed follicular lymphoma tfl improved rituximab era need upfront stem cell transplantation sct unclear evaluated outcomes patients treated first line chemotherapy histologically proven tfl institution majority patients receive sct part first line management median follow years year overall survival patients patients treated chop without upfront sct year cox regression analysis entire cohort international prognostic index ipi risk group presence symptoms transformation independently associated multivariate analysis mva analysis confirms improved survival tfl rituximab era even absence upfront sct consolidation
propose novel approximation technique bubble approximation repulsion forces body problem attraction limited range repulsion acts points kinds systems occur frequently dimension reduction graph drawing like tree codes established body approximation method replaces several point point computations one area point computation novelty consider magnitudes also directions forces area therefore area point approximations applicable anywhere space joint effect forces inside area calculated analytically assuming homogeneous mass points inside area two features free hierarchical data structures complicated bookkeeping interactions plague tree codes instead uses simple graph control computations graph provides sparse matrix suitably weighted replaces full matrix pairwise comparisons body problem concrete example implement sparse matrix version stochastic neighbor embedding dimension reduction method demonstrate good performance comparisons full matrix method three different approximate versions method elsevier ltd rights reserved
generally rainwater harvesting less acceptable stable water resource countries large disparities seasonal rainfall including korea study rainwater harvesting system suitable south korea investigated systematically simulation method utilizing daily rainfall data collected last years developed determine critical size rainwater tank could supply harvested rainwater continuously estimation rainwater tank size simplified developing correlation volume area fractions extensive simulation performed evaluate feasibility rainwater harvesting seven major cities south korea resulting rainwater tank large economically feasible compared daily harvested rainwater used thus rainwater harvesting system integrated alternative water resources wastewater reclamation membrane bioreactor mbr enhance applicability rainwater harvesting without compromising continuous water supply
innovative computationally efficient method simultaneous determination top dead centre tdc offset pressure offset presented based characteristic deviations rate heat release rohr specific offsets compression phase expansion phase end combustion characteristic deviations rohr derived first principles also confirmed manual shifts pressure trace rohr calculated based first law thermodynamics using cylinder pressure trace engine geometrical parameters operating point specific parameters method applied line analyses using averaged pressure trace line analyses using single pressure trace application areas method simultaneously determines tdc position pressure offset within single processing pressure trace whereas second refinement step performed obtaining accurate results correction factors determined accurately using nearly converged input data innovative analytic basis method allows significant reduction computational times compared existing methods simultaneous determination tdc offset pressure offset fired conditions method validated heavy duty light duty diesel engine
first years life children spend good proportion time sleeping well acquiring meanings hundreds words ample evidence effects sleep memory adults number studies demonstrating effects napping nocturnal sleep children also mounting particular sleep appears benefit children memory recently encountered novel words effect sleep children generalization novel words across multiple items however less clear given sleep polyphasic early years made multiple episodes children word learning gradual strengthened slowly time highly plausible sleep strong candidate supporting children memory novel words importantly appears children sleep shortly exposure novel word object pairs retention better sleep delayed suggesting napping plays vital role long term word retention young children word learning complex challenging important part development thus role sleep plays children retention novel words worthy attention ensuring children get sufficient good quality sleep regular opportunities nap may critical language acquisition
methylmercury mehg environmental neurotoxicant adverse effects particularly noted developing brain main source mehg exposure seafood however fish also important source fatty acids docosahexaenoic acid dha neuroprotective effects plays important role prenatal development central nervous system aim present study examine effects dha mehg individually combination development using accumulation behavioural transcriptomic endpoints mammalian model analyses performed day old mice exposed varying levels dha mehg throughout development via maternal diet supplementation maternal diet dha reduced mehg accumulation brain accelerated development grasping reflex seen mice offspring mehg high dha group compared mehg control exposure mehg dha impact cerebral gene expression assessed microarray qpcr analysis results present study show potential dha alleviating toxicity caused mehg information may contribute towards refining risk benefit assessment seafood consumption may enhance understanding discrepancies epidemiological studies mehg neurodevelopmental toxicity elsevier rights reserved
phase computer generated holography cgh calculation method stereoscopic holography proposed paper two dimensional perspective projection views three dimensional object generated computer graphics rendering techniques based views phase hologram calculated using gerchberg saxton iterative algorithm comparing non iterative algorithm conventional stereoscopic holography proposed method improves holographic image quality especially phase hologram encoded complex distribution simulation optical experiment results demonstrate proposed method give higher quality reconstruction comparing traditional method
paper presents simple accurate method estimate time varying frequency single phase electric power systems based three equally spaced samples sinusoidal voltage signal model without offset time varying frequency assumed analytical formulas derived method shows good estimation accuracy real world wide range frequency changes simulations performed elsevier ltd rights reserved
describe recent advances wideband analog signal processing via microwave photonics emphasis realisation chirped microwave photonic filter high resolution filtering shape invariance tuning linearized photonic mixer structure achieving high spurious free dynamic range performance
previous research already firmly established negative relationship intelligence racial prejudice yet far role self perceived intelligence explaining racial prejudice remains uninvestigated present study therefore compared effects intelligence test scores self perceived intelligence racial prejudice using belgian community sample results revealed opposite relationships whereas individuals scored higher lower intelligence test showed lower levels racial prejudice individuals perceived intelligent compared others showed higher levels racial prejudice additional mediation analyses showed negative relationship actual intelligence racial prejudice mediated essentialist thinking whereas positive association self perceived intelligence racial prejudice mediated social dominance orientation present results indicate intelligent related less racial prejudice judging one intelligent others related racial prejudice elsevier ltd rights reserved
rate drainage viscous liquid initially full cylindrical tubes inclined various angles vertical degrees degrees degrees degrees studied glass polymethylmethacrylate perspex tubes various lengths diameters using three food materials honey newtonian two variants marmite spread exhibiting complex rheological behaviour including shear thinning thixotropy behaviour marked initially steady rate drainage air slug descended tube followed slower drainage annular film remaining wall eventually liquid stopped draining filament entered dripping regime drainage insensitive tube material whereas stages drainage influenced geometry angle inclination quantitative models presented rate extent initial drainage stage rate second linear stage existed rate drainage third falling rate stage fourth final stage characterised drop formation modelled initial rate predicted reasonable accuracy allowing time remove approximately material short waiting phase calculated newtonian liquid kinematic viscosity vertical pipe radius length agreement models less exact capture general trends reasonably authors published elsevier
paper addresses complete set procedures study better understand emerging problem biofouling formation photobioreactors pbrs methodologies described detail pbr microalgae mat surface preparation contact angles zeta potential measurements microalgal cells pbr surfaces iii microscopic methods studying evolution adhesion intensity impact methodologies may photosynthetic apparatus cells biomass concentration cell viability also quantified lab scale flat plate pbr used performa long term batch culture marine microalgae nannochloropsis gaditana devised rack pbr glass surfaces submerged study cell cell cell pbr surface interactions existing surface thermodynamics colloidal theories xdlvo used major outcomes gaditana exposure time threshold electric field produced meter linear equation provided predicting pbr surface potential function culture medium ionic strength biofouling growth curve pbr surface varied line growth kinetic followed freely suspended culture cells devised pbr slide rack system offers versatile experimental platform generating biofouling results making suitable situ efficiency evaluation antibiofouling coatings significant variation surface free energy pbr surfaces algal mats respect present beginning culture consequently application thermodynamic theories failed predict cell adhesion long term cultivation however xdlvo model satisfactorily explained dynamics adhesion studied reported results might useful research microalgal production pbr engineering area elsevier rights reserved
fluctuations water surface elevation wse along rivers important implications water resources flood hazards biogeochemical cycling however current situ remote sensing methods exhibit key limitations characterizing spatiotemporal hydraulics many world river systems analyze new measurements river wse slope airswot airborne analogue surface water ocean topography swot mission aimed addressing limitations current remotely sensed observations surface water evaluate capabilities compare airswot wses slopes situ measurements along tanana river alaska root mean square error wses averaged areas slopes along reaches results indicate airswot accurately reproduce spatial variations slope critical characterizing reach scale hydraulics airswot high precision measurements valuable hydrologic analysis flood modeling studies validating future swot measurements
robotic manipulators complex coupled nonlinear systems therefore designing effective controller systems quite complicated main hurdle operating systems inter linkage links removed using decoupling method decoupling links good idea viewpoint practical applications paper fractional order hybrid fuzzy logic controller fohflc scheme developed two degree freedom rigid planar robotic manipulator payload dof rprmwp plant trajectory tracking cuckoo search algorithm csa utilized finding optimal parameters proposed approach witnessing effectiveness performance proposed fohflc scheme compared integer order hybrid flc iohflc approach conventional pid controller robustness testing investigated parameter variations disturbance rejection proposed controller schemes
paper introduce simple effective algorithm detect image precise location moving targets behind obstacles based one transmitter two receiver configuration problem geometry together formulation details algorithm given performance algorithm first evaluated synthesizing numerical scenario simulated moving ideal scatterers success validity algorithm assessed error analysis study calculates error associated approximations algorithm tested measured data obtained experimental set detecting human movement behind wall resultant two dimensional consecutive images indicate algorithm effectively used pinpointing moving targets twr similar obstacle radar applications good fidelity wiley periodicals inc
paper describes status achieved results future research plans related student project line board wind estimation system system planned augment functionality improve performance existing small uav flight control system units developed within students activities department control engineering faculty electrical engineering czech technical university prague simulated data prepared based realistic flight mechanics models simple algorithms adopted literature tailored case sensitivity measurement errors carefully analyzed finally performance algorithms demonstrated realistic simulation scenarios related hardware components also introduced discussed brief future plans elaborated
background protein contact dermatitis frequently reported case studies usually cases involving contact seafood products descriptive series objectives present study firstly determine incidence protein contact dermatitis among fishermen france compare data onshore work involving seafood exposure second discover factors could explain differences order answer questions analysed data french national occupational disease surveillance prevention network rnvp occupational diseases declared french national network monitoring prevention occupational disease retrospective study done year period case presentation found eight cases protein contact dermatitis french network cases protein contact dermatitis seafaring population eight cases french network essentially allergies different fish chefs professionals affected atopy present half cases seafaring population found several cases allergic delayed time contact dermatitis due bryozoans gloves protein contact dermatitis conclusions chefs cook seafood risk occupational protein contact dermatitis fishermen think skin protection say glove wearing better implemented fishing sector catering profession shore france
eye gaze potent source social information direct eye gaze signaling desire approach averted eye gaze signaling avoidance current work proposed eye gaze signals whether impute minds others across four studies manipulated targets eye gaze direct averted eye gaze measured explicit mind ascriptions study study study beliefs likelihood targets mind study four studies find novel evidence ascription sophisticated humanlike minds others signaled display direct eye gaze relative averted eye gaze moreover provide evidence suggesting differential mentalization due least part beliefs direct gaze targets likely instigate social interaction short eye contact triggers mind perception
skin ageing complex biological process influenced endogenous factors exogenous factors endogenous skin ageing genetically determined whereas exogenous skin ageing mainly environmentally triggered exposure sunlight smoking poor diet prevented strategies ageing skin focus antioxidants nutrition hormonal factors vitamins carotenoids vitamin flavonoids plant extracts offered form either topical preparations food supplements effect cases due temporary skin smoothing result accumulation water structural molecules upper layer dermis cases due effects protection sunlight furthermore skin suitable model general research ageing studies shown skin thickness bone density menopausal women strongly correlated vitro experiments human sebaceous glands shown modified signalling cascades context hormone induced ageing relate expression steroid hormones cytokines well involvement genes role inflammation pathogenesis neurogenerative disorders
cardiovascular disease cvd presents great burden elderly patients caregivers health systems structural functional alterations vessels accumulate throughout life culminating increased risk developing cvd growing elderly population worldwide highlights need understand aging promotes cvd order develop new strategies confront challenge review provides examples major unresolved clinical problems encountered daily cardiovascular practice care elderly patients next authors summarize current understanding mechanisms implicated cardiovascular aging potential targeting novel pathways implicated endothelial dysfunction mitochondrial oxidative stress chromatin remodeling genomic instability lastly authors consider critical aspects vascular repair including autologous transplantation bone marrow derived stem cells elderly patients coll cardiol american college cardiology foundation
studies reported intraplaque neovascularisation ipn closely correlated plaque vulnerability study new image processing approach differential intensity projection dip developed visualise quantify ipn contrast enhanced non linear ultrasound image sequences carotid arteries dip used difference local temporal maximum local temporal average signals identify bubbles tissue non linear artefact noise total absolute relative areas occupied bubbles within plaque calculated quantify ipn vitro measurements laboratory phantom made followed vivo measurements contrast enhanced non linear ultrasound image sequences carotid arteries patients selected motion corrected results using dip compared obtained maximum intensity projection mip visual assessment results indicated dip significantly reduce non linear propagation tissue artefacts much specific detecting bubble signals mip able reveal microbubble signals buried tissue artefacts corresponding mip image good correlation found microvascular area mva microvascular density obtained using dip corresponding expert visual grades comparing favourably obtained using mip data conclusion proposed method exhibits great potential quantification ipn contrast enhanced ultrasound images carotid arteries world federation ultrasound medicine biology
utilization wind turbines produce energy increasing recent years due technology advancement cost stability environmental issues paper wind resource economic feasibility studied avoid investment risk cites zabol zahak zahedan mirjaveh sistan balouchestan province iran weibull distribution function applied estimate wind power energy density using meteorological data determination coefficient root mean square error mean bias error mean bias absolute error also calculated ensure accuracy statistical analysis fitted distribution windographer software employed investigate prevailing wind direction estimated annual energy densities kwh year annual mean power densities found zabol zahedan suitable large scale power generation results indicate using wind turbines highly beneficial zabol zahak zahedan wind turbine appropriate generating electricity however mirjaveh suitable grid applications noted analysis monetary units presented dollar elsevier ltd rights reserved
due combination factors environmental concerns high oil prices potential peak oil development cleaner alternative fuels advanced power systems vehicles become high priority many governments vehicle manufacturers around world use gasoline alternative fuel gasoline engine becoming need looking scarcity petroleum fuels near future paper investigates influence compression ratio ethanol gasoline blending find effects four stroke engine performance research air cooled engine compression ratio used fuel blend used study engine operated speed range rpm maximum power obtained fuel compression ratio minimum fuel consumption rate obtained compression ratio clearly depicts compression ratio increases fuel consumption rate decreases considerably experimental results showed comparing several blends ethanol cost power effective four stroke engine
propose active method rectify geometric photometric distortions document image method uses structured beams projected upon curved document page recover spatial curves developable surface interpolated curves finding correspondence correct geometric distortion estimated developable surface finally flattened onto plane explicitly solving system ordinary differential equations recovered page shape together lambertian illumination model guidance used rectify non uniform illumination images experimental results based variety synthetic real captured document images demonstrate effectiveness efficiency proposed method
issue potential media effects psychological health youth young adults debated decades research media effects always consistent one issue raised regards whether relatively modest media effects found research might explained mediating personality variables hypothesis examined three samples young adults mexican americans croatians english results indicated trait aggression consistent predictor violent crimes depression across samples general personality variables less consistent predictors violence although neuroticism consistently predicted depression across samples media violence exposure predict negative outcomes except among croatians exposure violent video games predicted fewer violent crimes exposure television violence predicted increased violent crimes elsevier ltd rights reserved
paper proposes new approach power system transient stability simulation based semi analytical solution sas power system differential algebraic equations paper sas derived using adomian decomposition method closed form explicit function symbolic variables time initial state variables system conditions hence directly give power system dynamic trajectory accurate certain time window unlike traditional numerical integration based simulation approach proposed new approach offline derives sas online evaluates sas plugging values symbolic variables series time windows making desired simulation period paper studies maximum length time window sas accurate proposes divergence indicator simulation using adaptive time windows implementation new approach parallel computers also studied new approach validated contingency simulation ieee generator bus system detailed generator models
main purpose electrical network deliver efficiently reliable electricity consumers equilibrium production consumption principal objective guarantee stability electrical power system imbalance electricity supply demand load active reactive powers causes increment drop grid frequency voltage solve problem paper proposes control strategy based two supervisor algorithms algorithms integrated two diesel generators inverters participate ancillary services results prove robustness performance proposed control strategy
paper presents design implementation testing automation component prototype machinery destined cutting sorting bundling harvested src crops planting purposes device developed name rod picker result collaboration six partners four different countries rod picker project includes mechanical automation hydraulics sensor measurement concepts operates according conditions imposed beneficiaries short rotation coppice src farm owners agricultural machinery energy crops species producers freshly harvested material cut obeying diameter length restrictions sorted bundled packages ready distribution process automated requiring little intervention behalf operator cutting accuracy speed execution two features underline efficiency device compared manual rod processing methods measurement errors obtained machine indicates manually calculated length functionality tests performed several weeks laboratory industrial conditions confirm system properly designed implemented regarding economical evaluation conclusion working machinery decrease overall processing costs approximately five times compared manual labor authors published elsevier ltd open access article license http creativecommons org licenses
using event related potentials erps study examines trait information inferred behaviors associated person names linguistic discourses person names associated descriptions either positive negative behaviors subsequent explicit evaluation task previously described person names presented isolation participants asked judge emotional valence names found names associated positive descriptions elicited larger positivity erp names associated negative descriptions results indicate emotional valence person names attached person perception dynamically influenced short descriptions target person probably due trait inference based provided behavioral descriptions
cost reduction photovoltaic module makes solar energy promising renewable energy large scale electricity generation controlling green house gas emissions primary obstacle connection generation electric grid poor stability due variation solar radiation determines output pumped hydroelectric storage phs efficient energy storage method stabilize intermittent output tibet solar radiation abundance presents opportunity install stations across china unified construction phs necessary grid connected utilization solar energy objectives study evaluate phs potential tibet provide promising locations phs stations geographic information science gis analyses review existing gis methods phs site selection firstly given two new gis models appropriate tibetan area proposed considered assessment results showed total phs potential tibet respectively promising sites mapped assessment sites made according distances grid connections results supposed benefit planning phs facilities tibet
human insula implicated numerous functions neuroimaging studies focus region however atlas offers complete subdivision insula reference space aims study define protocol subdivide insula create probability maps mni stereotaxic space provide normative reference volume measurements subdivisions six regions manually delineated bilaterally images healthy subjects three short gyri anterior inferior cortex two long gyri volume insular grey matter native space mni space volumes expressed percentage ipsilateral grey matter volume minimally larger women men spatial normalization stereotactic probabilistic atlas subregion produced well maximum probability atlas taking account surrounding structures automatically labelling insular subregions via multi atlas propagation label fusion strategy maper leave one experiment showed high spatial overlaps automatically defined insular subregions manually derived ones mean jaccard index corresponding mean dice index average mean volume error probabilistic maximum probability atlases original delineations available web free academic licences
capstone design opportunity students apply newly obtained knowledge real world setting oregon state university school mechanical industrial manufacturing engineering provides students choices internally originating within department offering capstone course externally sponsored projects uses assessment system based written reports quality deliverable prototype providing different projects group students made tracking managing progress project difficult large amount work required provide necessary support students historically fallen faculty however recently much work shifted graduate student assistants graduate students serve technical advisers project managers centralized communication hubs report graders compared faculty graduate students tend accessible students project sponsors instructors seem motivated provide high quality results provide comparable levels student assessments easier hold accountable many graduate students capstone projects extensions research concerns graduate student inexperience resolved faculty member available support necessary several tiers graduate advisers used illustrated case studies first tier uses graduate students simply report graders second tier adds project advising third tier adds responsibility creating device testing equipment capstone students use validating design meets requirements fourth tier includes grading advising responsibility extend necessary output capstone students work create fully functioning deliverable sponsor fifth tier similar fourth project topic key component graduate students degree research case studies faculty graduate adviser grade comparisons content analysis student reports graduate assistants observed valuable contributors enhanced capstone course levels involvement
background aims aims study examine association social skills deficits internet addictio activities adolescents attention deficit hyperactivity disorder adhd well moderators association methods total adolescents aged years diagnosed adhd participated study internet addiction levels social skills deficits adhd parental characteristics comorbidities assessed various internet activities participants engaged also examined results associations social skills deficits internet addiction activities moderators associations examined using logistic regression analyses social skills deficits significantly associated increased risk internet addiction adjustment effects factors odds ratio confidence interval social skills deficits also significantly associated internet gaming watching movies maternal occupational socioeconomic levels participants moderated association social skills deficits internet addiction conclusions social skills deficits considered targets prevention intervention programs treating internet addiction among adolescents adhd
objectives despite exponential proliferation chinese diabetes applications none designed meet needs largest potential user population purpose study examine features contents chinese diabetes mobile applications terms suitability use older adults diabetes methods search apple application store mobile assistant conducted identify chinese diabetes applications next compared features contents included popular diabetes applications international diabetes federation idf clinical guideline recommended usability criteria older adults respectively results seventy one diabetes apps randomly selected pool diabetes apps reviewed features apps failed include content areas known importance managing diabetes older adults usability tested applications rated moderate good conclusions designing maximally effective medical applications would benefit attention usability content guidelines targeted largest potential user population despite preponderance older adults potential user group failing consider relevance content addition usability specific population ultimately limit usefulness app elsevier rights reserved
paper results investigation electrical drive hybrid flying platform bal presented due restrictions flying platforms necessary use solutions limited number sensors purpose investigation two versions electrical drives bldc motor without speed feedback conducted obtained results compared conclusions regarding practical use motor drive made investigations discussed paper concern proposed methods speed estimation based current measurement
consider dimensional lattice path models restricted first orthant whose defining step sets exhibit reflective symmetry across every axis given model provide explicit asymptotic enumerative formulas number walks fixed length exponential growth given number distinct steps model take sub exponential growth depends dimension underlying lattice number steps moving forward coordinate generating function model first expressed diagonal multivariate rational function asymptotic expressions derived analyzing singular variety rational function additionally show compute subdominant growth reflect difference rational diagonals differential equations data structures finite functions show determine first order asymptotics subset walks start end origin
sandwich like molybdenum sulfide mesoporous organosilica nanosheets denoted mos mos prepared first time via direct growth ethane bridged mesostructured organosilica mos nanosheets using cetyltrimethylammonium bromide ctab structure directing agent obtained mos mos nanosheets possess well defined sandwich like structure high surface area similar uniform pore size similar large pore volume similar vitro cytotoxicity assessments demonstrate mos mos nanosheets excellent biocompatibility owing encapsulation mos obtained mos mos nanosheets photo thermal conversion capability photo thermally controlled drug release property properties make mos mos nanosheets promising biomedical applications elsevier inc rights reserved
water liquids cause production problems natural gas wells established labour intensive method removing liquids use absorbent foam sticks lowered wells lifted back paper presents automated solution launching foam sticks gas wells recovering without need grid electricity supply foam stick launching apparatus enclosed magazine several chambers controlled solar powered skid mounted electric pneumatic control system includes storage battery time relays wireless switch module compressed gas supply typical water producing gas well selected illustrate technology successful application indicates engineers remove liquid water producing gas wells bring back production normally using novel artificial lift technology also used remote areas electrical supply
backgroundessential trace elements vital human health study aim establish reference intervals evaluate relationships among children methodswe collected blood samples children aged years china concentrations elements determined atomizer absorption spectrophotometer nonparametric method used establish reference intervals resultsgender related differences concentrations statistically significant elements except strong positive negative correlations age age respectively correlations similar similar similar strongest compared others multivariable linear regression adjusted confounding factors associations strongest per concentration quintile increase caused increasing respectively conclusionsgender age based reference intervals children established correlations quite complex works needed illuminate relationships impacts children health
background early diagnosis food allergies important favorable prognosis study aimed determine level awareness among pediatricians kuwait method item self administered questionnaire designed distributed pediatricians working government hospitals kuwait results total pediatricians completed questionnaire participation rate males females mean age participants years mean number years working pediatrics years mean overall knowledge score pediatricians overall knowledge scores found significantly associated age older pediatricians higher overall scores years experience pediatrician independent hospital site gender rank multiple linear regression revealed pediatrician age gender variables significantly associated overall knowledge score participants answered least survey questions correctly questions correctly answered participants constituted clinical presentation questions diagnostics questions treatment questions prevention questions interestingly among pediatricians determined felt comfortable evaluating treating patients passed questionnaire conclusions survey demonstrates noteworthy deficiency pediatricians awareness implementation strategies improve pediatricians awareness critical diagnose food allergy patients early improve health outcomes
paper addresses position control valve controlled cylinder system employed hydraulic excavator nonlinearities dead zone saturation discharge coefficient friction existed system highlighted mathematical modeling basis simulation model established validated experiments aim achieving excellent position control performances improved particle swarm optimization pso algorithm presented search optimal proportional integral derivative pid controller gains nonlinear hydraulic system proposed algorithm hybrid based standard pso algorithm addition selection crossover operators genetic algorithm order enhance searching efficiency furthermore nonlinear decreasing scheme inertia weight improved pso algorithm adopted balance global exploration local exploration abilities particles simulation platform combining simulation model improved pso tuning based pid controller developed comparisons improved pso standard pso phase margin tuning methods carried three position references step signal ramp signal sinusoidal wave using simulation platform results demonstrated improved pso algorithm perform well pid control positioning nonlinear hydraulic system elsevier ltd rights reserved
aim study identify factors best predictors sexist attitudes achieve aim two groups variables analysed first group consisted variables relating parenting styles division housework second group consisted personal factors related prosocial behaviour physical verbal aggression sample made adolescents aged valencia spain analysis conducted separately boys girls correlation analyses multiple linear regression analyses conducted subsample results show division housework parenting styles related sexist attitudes connection especially strong division housework according traditional gender roles found lead hostile benevolent sexist attitudes results also showed prosocial aggressive behaviours correlated sexist attitudes results varied gender findings research implications prevention sexist attitudes
eastern canada several grape vitis spp cultivars susceptible downy mildew plasmopara viticola hybrids chancellor vidal protected soil geotextile fabric winter months practice although useful protecting vines winter injuries provides shelter viticola oospores adverse winter conditions thus expected large proportion viticola oospores overwinter objective study investigate relationship fall downy mildew incidence disease development following spring relationship established using data collected plantings cultivars chancellor vidal seyval blanc plots fall mildew incidence downy mildew severity assessed weekly bud break harvest proportion leaf area diseased bloom harvest area disease progress curve time maximum disease rate disease progress yield estimated regardless cultivar year fall mildew incidence significant effect mildew progress higher fall mildew incidence associated earlier development symptoms higher severity mildew bloom following spring information could used determine appropriate strategy manage downy mildew following spring however research needed determine management strategies adapted various levels risk
micrornas mirna implicated variety pathological conditions including infectious diseases knowledge mirnas affected poly synthetic analog viral double stranded rna porcine airway epithelial cells paecs contributes understanding mechanisms swine viral respiratory diseases bring enormous economic loss worldwide every year study used high throughput sequencing profile mirna expression paecs treated poly compared untreated control approach revealed differentially expressed mirnas dems five implicated viral infection nineteen mirnas downregulated including members mir cluster well known polycistronic oncomir extensively involved viral infection humans target genes dems predicted using bioinformatic methods validated luciferase reporter analysis two representative dems significantly enriched several pathways including transforming growth factor signaling large quantity sequence variations isomirs found including substitution position verified redirect mirnas new spectrum targets luciferase reporter assay together bioinformatics analysis twelve novel porcine mirnas conserved species identified homology analysis together cloning verification furthermore expression analysis revealed potential importance three novel mirnas porcine immune response viruses overall data contribute clarifying mechanisms underlying host immune response respiratory viruses pigs enriches repertoire porcine mirnas
aim study identify specific cognitive abilities predict functional outcome high functioning adults autism spectrum disorder asd clarify contribution abilities relationships total adults asd performed cognitive tasks broad range neuro social cognitive domains information concerning functional outcomes obtained regression analyses revealed emotion perception verbal generativity predicted adaptive functioning directly former mediated two findings provide first evidence triadic relationship among neuro social cognition functional outcome population results suggest psychosocial interventions targeting cognitive abilities could benefit social adaptation adults asd
automating fabric defect detection significant role fabric industries however existing fabric defect detection algorithms lack real time performance required real applications due high demanding computation ensure real time high accuracy reliable fabric defect detection paper developed fast parallel normalized cross correlation algorithm based summed area table technique called pfdd sat meet real time requirements extensive use nvidia cuda framework graphical processing unit gpu computing made detailed implementation steps pfdd sat illustrated paper several experiments carried evaluate detection time accuracy robustness illumination gaussian noises results show pfdd sat robustness noise speeds defect detection process times normal required time greatly met needs real time automatic fabric defect detection
background depression complex neuropsychiatric syndrome often severe life threatening spite remarkable progress understanding neural biology etiopathophysiology depression still elusive study investigated molecular mechanisms prefrontal cortex mice showing depression like phenotype induced chronic defeat stress methods depression like phenotype induced cbl mice subjecting day social defeat paradigm metabolic activity excitatory glutamatergic inhibitory gamma aminobutyric acid gaba ergic neurons prefrontal cortex measured nuclear magnetic resonance spectroscopy together infusion glucose addition expression level genes associated glutamatergic gabaergic pathways monitored quantitative polymerase chain reaction results mice showing depression like phenotype exhibit significant reduction levels glutamate glutamine acetyl aspartate taurine prefrontal cortex importantly findings reduced labeling glutamate glutamate gaba glucose indicate decreased glutamatergic gabaergic neuronal metabolism neurotransmitter cycling depressed mice reduced glutamine labeling suggests decreased neurotransmitter cycling depression quantitative polymerase chain reaction analysis revealed reduced transcripts gad eaat genes code enzymes involved synthesis gaba clearance glutamate synapses respectively conclusions data indicate activities glutamatergic gabaergic neurons reduced mice showing depression like phenotype supported molecular data expression genes involved glutamate gaba pathways
background phosphatidylinositol kinase delta pik delta inhibitor idelalisib shown block downstream intracellular signaling reduce production prosurvival chemokines induce apoptosis classical hodgkin lymphoma cell lines also shown inhibit regulatory cells myeloid derived suppressor cells tumor models hypothesized inhibiting pik delta would direct indirect antitumor effects directly targeting malignant cells well modulating inflammatory microenvironment tested hypothesis phase study patients methods enrolled patients relapsed refractory median age years previously received median five therapies including failed autologous stem cell transplant failed brentuximab vedotin prior radiation therapy idelalisib administered two times daily increase two times daily permitted time disease progression results overall response rate idelalisib therapy confidence interval median time response months seventeen patients experienced reduction target lesions one complete remission four partial remissions median duration response months median progression free survival months common grade adverse event elevation alanine aminotransferase two patients diarrhea colitis seen three patients grade one adverse event leading death hypoxia conclusions idelalisib tolerable modest single agent activity heavily pretreated patients rational combinations novel agents may improve response rate duration response
monolithic integrated low voltage deep brain stimulator wireless power data transmission presented data power transmitted stimulator mutual inductance coupling vitro controller encodes stimulation parameters stimulator integrates digital control module generate bipolar current equal amplitude four channels order reduce power consumption novel controlled threshold voltage cancellation rectifier proposed paper provide supply voltage stimulator monolithic stimulator fabricated smic poly metal mixed signal cmos process occupying consumes average compared previously published stimulators design advantages large stimulated current double low voltage supply high level integration
paper conduct research development direction trend interior design education green building background due development social economy people living standard rise public produced great changes requirement interior design interior designers professional ability also put forward higher requirements main position interior design talent cultivation universities professional interior design must according changes corresponding education reform reform must construction curriculum system teaching content teaching method aspects interior design education promote time order achieve purpose research proposes novel paradigm interior design education enhance current teaching mode
organization economic operation development oecd programme international assessment adult competencies piaac put forward landmark development lifelong monitoring international comparison education first round piaac survey adult skills compared performance literacy numeracy problem solving technology rich environments across countries however translation oecd agenda national policies mediated many actors including media paper examines compares national media japan england france reported piaac results countries extent reports mirror key messages oecd country notes begins trace oecd piaac agendas materialise national policies although role initial period limited argue roles media together policy actors must monitored interact shape possibilities sustainable adult education policies
current sources critical performance bioimpedance health monitoring device challenging features high accuracy wide bandwidth voltage controlled current source stable safe current magnitudes corresponding typical measurement requirements allow typical load impedances range omega omega high output impedance approximately omega khz omega high frequencies mhz without harmonics influence stray capacitances generalized impedance converters negative impedance converters help reduce influence stray capacitances study compare two types voltage controlled current sources grounded loads howland tietze circuits based study suggest improved howland circuit inverting dual configuration negative feedback using high bandwidth amplifier configuration better accuracy reached higher frequencies mhz addition compensation capacitor operational amplifier circuit configuration capable maintain approximately constant current amplitude within accuracy less low high frequencies mhz elsevier ltd rights reserved
paper presents device developed basis adjustable passive reactive power compensator intended increase power factor electric locomotive configuration contributes increase power factor locomotive working modes operation due approximation power factor value maximum possible values compensator operated method extreme voltage control autonomous voltage inverter mathematical modeling work electric locomotive equipped compensator performed matlab package showed possibility increase power factor published elsevier ltd
crop simulation models valuable tools quantifying crop yield response water devising strategies improve agricultural water management however applicability majority crop models limited greatly failure provide open access model source code study present open source version fao aquacrop model simulates efficiently water limited crop production across diverse environmental agronomic conditions model called aquacrop opensource aquacrop run multiple programming languages operating systems support parallel execution reduces significantly simulation times applying model large geospatial frameworks long run policy analysis uncertainty assessment furthermore aquacrop compliant open modelling interface standard facilitating linkage disciplinary models example guide integrated water resources planning author published elsevier
study investigates potential threats conflicts shadowing social harmony johor malaysia state johor inhabited plural yet segregated ethnic groups thus making prone communal conflicts process data collection conducted interviews respondents regions well extensive field observations study shows notwithstanding conflict potential confined low intensity sporadic quarrel impact tension frequently occurred within families relatives lead clashes larger community turn incites various kinds prejudice among fragmented communities worse still individual perception tolerance respect religious aspects quite concerning albeit demonstrable context inter ethnic relations nonetheless two sensitive issues perpetrating social incompatibilities detected construction worship places defamation different religious identities
objective explore subjective quality life qol children tourette syndrome china provide basis effective interference method total patients controls enrolled subjective qol investigated inventory subjective life quality family environment scale chinese version yale global tic severity scale case control study performed results total score subjective qol family life school life peer relationship cognitive component environment self awareness cognitive component depression experience lower control patients morbid exhibited significantly lower scores within subjective qol family life peer relationship school life self awareness cognitive affective domains conclusion subjective qol impaired important control clinical symptoms improve family environment improvement subjective qol
aim present study analyse highly cited papers india science citation index expanded database used retrieve related bibliographic records grouping reclassification institutions misspellings variants done productive institutions collaborating partners index contributing authors examined results revealed highly cited papers india receive citations early years publication authored international collaboration papers received citation impact single authored ones usa preferred collaborative partner international collaboration indian institutes technology csir organizations indian institute science bengaluru leading indian institutions
cloud computing promising utility based distributed computing environment resources hardware software offered service internet pay per use basis involves elastic resource provisioning capabilities hence charge cloud resources actually needed however true elasticity cost effectiveness pay per use cloud business model achieved yet auto scaling techniques cloud allow horizontal scaling adding duplicate instances fully consider users expected performance pricing services since cloud platforms offer plethora server configurations different pricing ability scale varied size instances provide greater elasticity hence significant improvements cost resource utilization work heterogeneity aware auto scaling algorithm adapts workload changes maintaining quality service qos proposed proposed method uses online profiling cloud resources workload history analytically estimate subsequent resource requirements employs heuristic provision smallest set different size resource configurations order meet qos targets reduced cost improved resource utilization simulation based experimental evaluation representative web scientific workload patterns indicate proposed auto scaling technique exhibits better performance compared contemporary horizontal scaling approaches
background prosthetic clinics united states must attain accreditation order receive reimbursement medicare accreditation process requires clinics establish implement performance management plans quality improvement activities report describes experience seven prosthetic clinics collecting patientreported outcome data using improve quality services objectives describe experience prosthetic clinics implementing outcome monitoring quality improvement activities part routine patient care study design qualitative ethnographic design methods clinics incorporated orthotics prosthetics users survey routine care patients aged years older received new lower limb prosthesis socket orthotics prosthetics users survey measures lower extremity functional status quality life satisfaction device services clinics selected orthotics prosthetics users survey derived indicators implement quality improvement action plans results seven clinics participated three able sustain data collection two clinics initiated quality improvement activities focused improving declining satisfaction functional scores conclusions quality improvement activities based patient reported outcomes require high degree organizational commitment support external facilitation support clinics quality improvement activities
based toxic level severe situation water pollution compared effects chronic exposures growth survival histology ultrastructure oxidative stress liver zebrafish weeks growth performance survival rate remained relatively constant stress reduced exposure exposure also induced severe pyknotic nuclei evident ultrastructure damage considerable lipid inclusions hepatocytes however phenomena pronounced exposure negative effects caused may explained increase hepatic oxidative damage reflected enhanced levels lipid peroxidation lpo protein carbonylation reduced activity superoxide dismutase sod catalase cat may result enhanced hepatic oxidative damage though mrna protein levels genes increased remained unchanged respectively contrary regulated levels mrna protein activity sod may contribute decreased lpo levels nonetheless sharply regulated mrna levels cat induce increase protein activity levels cat stress furthermore transcription factor related factor nrf expression parelleled target genes suggesting nrf required protracted induction antioxidant genes conclusion data demonstrated essential non essential metals induced differences oxidative damage fish differences caused transcriptional level related genes depended post transcriptional modifications published elsevier
paper emergency fault tolerant controller developed quadrotor unmanned aerial vehicles uavs suffering total loss one actuator rotor motor proposed controller based control allocation infected actuator exempted control effect control efforts redistributed among healthy actuators result emergency controller transforms infected quadrotor trirotor uses remaining actuators ensure uav continues following path main advantage newcontroller uses simple proportional integral derivative pid controller applied fault free cases redistributing controls rather designing complex memory consumable controllers experimental results using augmented reality drone platform show implementing quadrotor trirotor conversion maneuver nominal pid controller gains powerful fault tolerant capabilities infected uav successful maintaining desired path performance degradation seen oscillations cause drone crash despite total loss yaw control presence activation delay nonsymmetric structure trirotor odd number rotors produces imbalance rotor moments
structural systems subject uncertainties due variability many hard control noise factors include external loads material properties construction workmanship traditional structural design methodologies although clearly recognizing presence uncertainty omit robustness effects uncertainty design process first actual uncertainties design process underestimated design may fail satisfy safety requirements second guarantee safety presence high variability system response structural designer may forced choose overly conservative thus inefficient costly design robustness uncertainty treated one design objectives trade design safety design cost savings exacerbated manuscript demonstrates safe cost effective structural engineering designs maybe achieved implementing robust design concepts originally developed manufacturing engineering consider robustness uncertainty manuscript presents optimization based methodology application robust design principles structural design demonstrates application academic problem involving design reinforced concrete frame elsevier ltd rights reserved
geosynthetics commonly used reinforcement layers bridge underground cavities sinkholes trenches support upper soil mass applications geosynthetics acting tensioned membranes plus effect soil arching maintain stability mitigate subsidence overlying soil study including two dimensional experimental testing subsequent numerical simulations investigates subsidence soil mass deformation geosynthetics roadway subdrain experimental study performed fabricated container trapdoors bottom one trapdoors lowered mimic trench subdrain cylindrical aluminum bars used soil experimental testing imitate two dimensional situations layer geotextile placed underneath soil fill serve reinforcement following experimental test numerical simulation carried using discrete element method pfcd extend scope experimental study results indicated deformed shape geosynthetic layer approximately parabolic subsidence decreased hyperbolically vertical direction lateral influence range appeared bounded two lines inclined degrees phi friction angle showed significant influence subsidence tension geosynthetic elsevier ltd rights reserved
migration may affect fertility child health care remaining country origin mexican data show least one household member migrated united states decreases occurrence pregnancy among teenagers probability points finding partially explained fact teenagers migrant households higher knowledge contraceptive methods likely practice active birth control use potential migration measured historic migration rates interacted proportion adult males household instrument account endogeneity migrant status
objective objective study determine clinical impact time antibiotic administration adult inpatients hematologic malignancies develop febrile neutropenia methods retrospective chart review conducted screen febrile neutropenia events amongst adult hematologic malignancy patients january september included patients admitted hospital time fever onset admitted diagnosis febrile neutropenia descriptive statistics logistic generalized estimated equations used analyze data results two hundred forty four neutropenic fever events met inclusion criteria thirty five events led negative clinical outcomes hospital mortality intensive care unit transfer vasopressor requirement inhouse mortality rate time antibiotics ranged min min median time antibiotics events led negative outcomes min compared min events lead negative outcome conditional order sets used order empiric antibiotics events significantly reduced time antibiotics min min conclusion prolonged time antibiotic administration hematologic malignancy patients develop neutropenic fever shown associated negative clinical outcomes
requirement develop organization makes collaboration organizations necessary organizations share resources perform common tasks different organizational domains use different access control models protect resources unauthorized access organizational collaboration important goal distributed computing paradigms policy inconsistencies domains cause problems collaboration model add problems involved constructing collaboration model problems provide two challenges motivate research presented construction collaboration model across multiple domains protected different access control models ensuring access control policy used participating domain contains inconsistencies also present new approach solving inter domain role mapping idrm problem determine minimal role set covers requested permissions collaborating domain also analyse algorithms present results tests compare results results existing approaches
mechanical design biological materials generated widespread interest recent years providing many insights intriguing structure property relationships critical characteristic load bearing materials central survival many species wear abrasion tolerance order fully functional protective armors dentitious structures dynamic appendages must able tolerate repetitive contact loads without significant loss materials internal damage however little known tribological performance using contact mechanics framework constructed materials selection charts provide general predictions wear performance biological materials function fundamental mechanical properties one key assumption constructing selection charts abrasion tolerance governed first irreversible damage contact point maps generated using comprehensive data literature encompass wide range materials heavily mineralized fully organic materials analysis shows tolerance biological materials abrasion depends contact geometry ultimately correlated environmental selective pressures comparisons experimental data nanoindentation experiments also drawn order verify predictions increasing amount data available biological materials also comes challenge selecting relevant model systems bioinspired materials engineering suggest maps able guide selection providing overview biological materials predicted exhibit best abrasion tolerance fundamental interest wide range applications instance restorative implants protective devices acta materialia inc published elsevier ltd rights reserved
series studies examine whether gender differences competition entry preferences moderated size competition drawing theories gender roles stereotypes show women relative men prefer enter smaller compared larger competitions studies demonstrate effect observational data preferences working differently sized firms applying differently sized colleges studies replicate effect real behavioral decisions different domains also find empirical evidence prescriptive gender norms stereotypes underlie effect study find experimental evidence women men differ preferences differently sized groups competition noncompetitive settings three additional experimental studies studies show perceptions comfort small versus larger competitions underlie women preferences findings suggest women preferences smaller competitions may driven adherence prescriptive gender norms discuss implications current findings gender inequalities organizations
wireless communication plays critical role determining lifetime internet things iot systems data aggregation approaches widely used enhance performance iot applications approaches reduce number packets transmitted combining multiple packets one transmission unit thereby minimising energy consumption collisions congestion however current data aggregation schemes restrict developers specific network structure handle multi hop data aggregation paper propose hitch hiker component binding model provides support multi hop data aggregation hitch hiker uses component meta data discover remote component bindings construct multi hop overlay network within free payload space existing traffic flows hitch hiker provides end end routing low priority traffic using small fraction energy standard communication paper extends upon previous work incorporating new mechanisms decentralised route discovery providing additional application case studies evaluation developed prototype implementation hitch hiker looci component model evaluation shows hitch hiker consumes minimal resources using hitch hiker deliver low priority traffic reduces energy consumption
currently psychopathy related terms antisocial personality disorder popular yet problematic constructs within forensic psychology disciplines psychopathy traced typically works pinel prichard early century even linked biblical passages although appears little support latter claim first use term psychopathy german psychiatry mid century referred psychological disturbance general personality diseases although german psychiatrists kraepelin propose specific definitions term related social deviance modern understanding psychopathy psychiatric disorder undetermined genetic origin involving antisocial elements lack feeling concern others owes much clinical work writings cleckley antisocial personality disorder appears similarly derive work psychiatric nosologists like kraepelin schneider sociopathy due work partridge
background quality life qol improvement main objective treating patients irritable bowel syndrome ibs study aimed assess validity reliability factor analysis ibs qol questionnaire common transcultural instrument iranian ibs patients materials methods two hundred forty patients ibs based gastroenterologists diagnosis according rom iii criteria referred digestive health clinic psychosomatic research center selected study aside ibs qol mos item short form health survey ibs severity index ibssi questionnaires completed cases determination correlation coefficients data analyzed using descriptive statistics factor analysis cronbach alpha pearson correlation coefficient statistical package social sciences spss software version results total reliability questionnaire reported using cronbach alpha ranging correlation coefficients concurrent implementation ibs qol ibssi resulted respectively exploratory factor analysis using varimax rotation identified eight principle components determine qol variance conclusion according results ibs qol questionnaire good psychometric properties research community safely used valid tool assess qol patients ibs healthcare therapeutic purposes
objective assess symptomatic outcomes associated flare discontinuation non steroidal anti inflammatory drugs nsaids axial spondyloarthritis axspa methods patients nsaid refractory axspa discontinued nsaids restarted symptoms recurred self recorded bath ankylosing spondylitis disease activity index basdai percentiles calculated changes basdai total components nsaid discontinuation resumption results percentiles absolute relative changes basdai total fatigue spinal pain joint pain swelling enthesitis morning stiffness conclusion single score threshold applied absolute change relative change indicated symptomatic deterioration basdai components
paper presents chopper instrumentation amplifier designed cmos technology operational amplifier rail rail folded cascode input stage ensures constant available common mode range characterized nested miller compensation transistors operate sub threshold region thus opamp designed specific procedure sub threshold operation chopper technique exploited reduce input referred offset noise circuit operates supply voltage exhibits simulated gain khz gbw montecarlo simulations demonstrate offset distribution standard deviation input noise spectral density equal giving noise efficiency factor
saliency detection task locating informative regions image challenging task computer vision contrast existing saliency detection models focus either local global image property effective salient object detection method introduced based joint modeling global shape local consistency end restricted boltzmann machine rbm utilized model salient object shape global image property conditional random field crf hand adopted achieve local consistency order obtain final saliency map universal framework introduced combine results rbm crf experimental results five benchmark datasets demonstrate proposed saliency detection method performs favorably existing state art algorithms
leverage authenticated data structures guarantee correctness completeness query results encrypted data contribution bridging two independent lines work searchable encryption provable data possession resulting general purpose technique without increasing client storage overhead small token data structure added server side comparison base searchable encryption without mechanisms determining result integrity data structure simultaneously also used integrity checks stored data elsevier rights reserved
paper investigates compares energetic ergonomic performance three different control logics pid fuzzy used regulate emission heating system energy efficient building tests carried experimental building equipped three electric radiators sensor network mapping internal external surface thermal conditions building technical system ensemble evaluated real time monitoring period five six days non occupancy winter midseason weather mediterranean climate controllers assessed regard thermal comfort energy consumption order return exhaustive scenario possible strengths weaknesses comparison showed fuzzy logic properly configured outperformed pid controllers reducing energy consumption maintaining thermal dissatisfaction comfort limits monitoring period elsevier rights reserved
transgenic expression pepper gene confers resistance xanthomonas campestris vesicatoria xcv pathogenic strains contain avrbs avirulence gene susceptible pepper tomato varieties avrbs gene highly conserved among members xanthomonas genus avrbs xcv shares homology avrbs xanthomonas citri subsp citri xcc causal agent citrus canker disease previous study showed transient expression pepper lemon leaves reduced canker formation induced plant defence mechanisms work effect stable expression gene citrus canker resistance evaluated transgenic plants citrus sinensis pineapple interestingly agrobacterium mediated transformation epicotyls unsuccessful constitutive promoter camv used plasmid construction seven transgenic lines obtained genetic construction harbouring control pathogen inducible promoter glutathione transferase gene potato reduction disease symptoms observed transgenic lines expressing respect non transformed control plants reduction directly dependent xcc avrbs gene since effect observed mutant strain xcc disruption avrbs gene used inoculations additionally canker symptom reduction correlated levels expression transgenic plants assessed real time qpcr accompanied production reactive oxygen species results indicate pepper resistance gene also functional family solanaceae could considered canker control
operation principle digital voltage mode controlled buck converter dual edge modulation analyzed paper based state equation buck converter six possible evolutions one switching cycle discrete iterative map model digital voltage mode controlled buck converter dual edge modulation established ignoring quantization error analog digital converter basis discrete iterative map model nonlinear dynamical behavior digital voltage mode controlled buck converter dual edge modulation investigated detail taking input voltage load resistance bifurcation parameters output voltage bifurcation diagram inductor current bifurcation diagram plotted analyzing bifurcation diagrams indicated two kinds similar different hopf bifurcation phenomena use poincare section time domain simulation waveforms phase portraits two different hopf bifurcations low frequency oscillation phenomena compared studied observing inductor current capacitor voltage waveforms respectively obviously found oscillation frequencies amplitudes different shapes two poincare sections phase portraits also different order verify correctness simulation theoretical analysis eigenvalues jacobian matrix discrete iterative map model introduced solved two kinds stable evolutions analyzing variation eigenvalues jacobi matrix input voltage existence difference two kinds hopf bifurcation phenomena proved theoretically moreover observed paper odd period doubling bifurcation phenomenon exists digital voltage mode controlled buck converter dual edge modulation first time operation state buck converter turns period one period three authenticity verified using time domain simulation waveforms phase portraits order approach actual circuit equivalent series resistances capacitor inductor considered actual circuit simulated using software psim comparison shows little differences theoretical simulation actual circuit simulation theoretical simulation used analyze performances actual circuit research results paper guiding significance practical value designing digital voltage mode controlled buck converter dual edge modulation
hip fractures elderly patients severe form fragility fractures lead significant morbidity mortality additionally enormous economic social burden treatment hip fractures elderly patients based prompt initial evaluation followed surgical treatment without unnecessary delays collaborative effort multidisciplinary team postoperative care started immediately surgery must include intensive rehabilitation well treatment osteoporosis metabolic imbalance review incorporates current literature initial evaluation definitive management hip fractures elderly intended assist practitioners different specialties treating patients
objective determine use carotid ultrasonography may improve cardiovascular risk stratification patients ankylosing spondylitis methods set consecutive patients without history events diabetes mellitus chronic kidney disease fulfilled definitions according modified new york criteria recruited assess carotid intima media thickness presence plaques risk calculated according systematic coronary risk evaluation score framingham risk score frs reynolds risk score rrs results men outnumbered women mean age time study years median interquartile range iqr disease duration years median iqr basdai time study hla positive syndesmophytes present carotid plaques found regardless algorithm used risk stratification patients classified moderate risk carotid plaques moreover fulfilled category low risk according total cholesterol score frs rrs respectively carotid plaques model included patients chart score score plus carotid plaques score diagnosis plus syndesmophytes carotid plaques score diagnosis plus extraarticular manifestations plus carotid plaques yielded highest sensitivity high high risk patients presence syndesmophytes associated increased risk carotid plaques fulfilled definitions low risk according score conclusion results support use carotid assessment risk patients
proposed method generates ground surface texture evaluating pressure applied point method standardizes diameter clod original size size defines condition land heft percentage clod four kinds size point ground pressure caused objects pass point accumulated whenever pressure exceeds threshold fixed ratio weight clod shifted half size result place many objects pass heft percentage smaller clod increases ground surface defined multilayered texture created combining four basic texture images images synthesized correspond size clod procedural method texture images round areas selected allocated one layers random diameter area equal size clod numbers area proportionate heft percentage clod multilayer texture combined one layer adding shade shadow finally mapped ground wiley periodicals inc electron comm jpn published online wiley online library wileyonlinelibrary com
many patient risk cardiovascular disease sleep disordered breathing sdb either obstructive intermittent collapse upper airway central episodic loss respiratory drive sdb associated sleep disturbance hypoxemia hemodynamic changes sympathetic activation patients worse prognosis without sdb mask based therapies positive airway pressure targeted sdb improve measures sleep quality partially normalize sleep respiratory physiology recent randomized trials cardiovascular outcomes sdb either neutral obstructive sleep apnea suggested possibility harm likely increased sudden death central sleep apnea alternative methods treatment sdb explored including implantable technologies studied adequately powered randomized controlled studies international guidelines recommend screening sdb done easily clinical practice may role treatment patients obstructive sleep apnea daytime sleepiness resistant hypertension atrial fibrillation randomised outcome studies required determine whether mask based treatment sdb appropriate patients chronic systolic heart failure obstructive sleep apnea heart failure preserved ejection fraction decompensated heart failure case made longer surrogate endpoints improvement respiratory sleep metrics taken adequate therapeutic outcome measures patients sleep apnea cardiovascular disease
measuring proportion variance explained statistical model relative importance specific predictors semi partial essential considerations building parsimonious statistical model statistic familiar summary goodnessof fit normal linear models extended various ways general models particular generalized linear mixed model glmm extends normal linear model used analyze correlated hierarchical non normal data structures although various statistics proposed consensus statistical literature sensible definition context research aims build upon existing knowledge definitions concisely define statistic glmm derive model semi partial statistic fixed population effects glmm utilizing penalized quasi likelihood estimation method based linearization show proposed statistic generalizes widely used marginal statistic introduced nakagawa schielzeth demonstrate statistics capability model selection show utility semi partial statistics longitudinal data analysis provide software computes proposed statistic along semi partial individual fixed effects software provided adapted sas programming languages
based findings qualitative study northern uganda article explores factors leading gender based violence gbv post conflict african context crisis masculinity becomes crucial understanding women vulnerability gbv crisis stems trauma losing one internal resources socially constructed identity role purpose one external resources wealth productive assets find armed conflict replaces positive male identity household head destructive model masculinity interaction negative masculinities extreme poverty characterises prevalence gbv conditions sur base des conclusions une etude qualitative menee dans nord ouganda cet article examine les facteurs aboutissant violence sexiste dans contexte africain post conflit crise masculinite devient cruciale moment comprendre vulnerabilite des femmes faces violence sexiste cette crise decoule traumatisme entraine pour une personne perte ses propres ressources internes identite role finalite socialement construits ses ressources internes richesses biens production nous constatons que conflit arme remplace identite masculine positive chef famille par modele destructeur masculinite est interaction entre les masculinites negatives pauvrete extreme qui caracterise prevalence violence sexiste dans ces conditions basandose los hallazgos surgidos estudio cualitativo efectuado norte uganda presente articulo examina los factores generadores violencia basada genero vbg contexto africano posconflicto para comprender vulnerabilidad que ven expuestas las mujeres debido vbg crisis masculinidad este tipo contexto adquiere rol crucial esta consecuencia del trauma generado por perdida recursos internos roles identidad finalidad construidos socialmente recursos externos riqueza activos productivos este sentido las autoras identificaron que conflicto armado remplaza positiva identidad masculina como jefe familia por modelo masculinidad destructivo dando lugar que estas condiciones prevalezca vbg generada por interaccion entre las masculinidades negativas pobreza extrema
energy bandgaps observed increase decreasing diameter due quantum confinement quasi one dimensional semiconductor nanostructures nanowires similar effect observed semimetal nanowires sufficiently small wire diameters bandgap induced semimetal nanowire becomes semiconductor demonstrate length scale semimetal semiconductor transition occurs enables use bandgap engineering form field effect transistor near atomic dimensions eliminates need doping transistor source channel drain removing requirement supply free carriers introducing dopant impurities quantum confinement allows materials engineering overcome primary obstacle fabricating sub transistors enabling aggressive scaling near atomic limits
aim explore kaumtua attitudes towards physician aid dying gain clear understanding attitudes may influence shape expectations medical care end life assist health professionals aotearoa new zealand address healthcare needs older mori near end life design kaupapa mori consistent approach undertaken systematic narrative technique employed qualitative data analysis data triangulated independent data coding three researchers two identified mori researchers ensure robust consistent method analysis well adhering kaupapa mori research approach setting participants recruitment participants kaumtua kupenga hauora mori mori leadership within faculty medical health sciences university auckland local auckland marae focus group individual interviews per preference undertaken kaumtua auckland region results five closely interrelated themes identified kaumtua narratives regarding physician aid dying attitudes understandings physician aid dying influence power significance kawa whnau relationships significance wairua conclusion study demonstrated kaumtua medical practices hasten death physician aid dying dying tikanga kawa important processes concepts understand death dying whnau central processes respected involved dying process factors closely intertwined considered separation
parallel computing systems promise higher performance computationally intensive applications since programmes parallel systems consist tasks executed simultaneously task scheduling becomes crucial performance applications given dependence constraints tasks arbitrary sizes bounded resources available execution optimal task scheduling considered hard problem therefore proposed scheduling algorithms based heuristics paper presents novel list scheduling heuristic called noodle heuristic noodle simple yet effective scheduling heuristic differs existing list scheduling techniques way assigns task priorities priority mechanism noodle maintains proportionate fairness among ready tasks belonging paths within task graph conduct extensive experimental evaluation noodle heuristic task graphs taken standard task graph experimental study includes results task graphs comprising tasks per graph execution scenarios core systems report results average schedule length ratio slr obtained producing variations communication computation cost ratio also analyse results different degree parallelism number edges task graphs results demonstrate noodle produces schedules within maximum worst case optimal schedule core systems also compare noodle existing scheduling heuristics perform comparative analysis performance noodle outperforms existing heuristics average slr values
design advanced reliability piezoelectric transducer acoustic emission suggested advanced reliability achieved eliminating main reasons lead failures duplicating backing main operating systems imparting redundant extended technical capabilities transducer design make possible compensate partial complete performance loss antenna group shown given design approach feasible achieve technical characteristics stipulated industrial acoustic emission transducers theoretical estimates transducer reliability presented show combination backing registration channels different versions connection gives ample opportunities governing reliability sensors usage service life
glacial moulins meltwater routed glacier surface base moulins main feature feeding subglacial drainage systems thus influencing basal motion ice dynamics geometry remains poorly known show analysis seismic wavefield generated water falling moulin help constrain geometry present modeling results hour long seimic tremors emitted vertical moulin shaft observed seismometer array installed surface greenland ice sheet tremor triggered moulin water level exceeded certain height associate threshold waterfall hit directly surface moulin water column amplitude tremor signal changed tremor episode close relation amount inflowing water tremor spectrum features multiple prominent peaks whose characteristic frequencies distributed like resonant modes semiopen organ pipe found depend moulin water level consistent source composed resonant tube waves water pressure waves coupled elastic deformation moulin walls along water filled moulin pipe analysis surface particle motions lends support interpretation seismic wavefield modeled superposition sustained wave radiation pressure sources side walls bottom moulin former found dominate wave field close distance latter large distance moulin
cercospora beticola economically significant fungal pathogen sugar beet causative pathogen cercospora leaf spot selected host genotypes contrasting degree susceptibility disease exploited characterize patterns metabolite responses fungal infection devise pre symptomatic non invasive method detecting presence pathogen sugar beet genotypes analyzed metabolite profiles hyperspectral signatures correlation data matrices approaches facilitated identification candidates metabolic markers hyperspectral imaging highly predictive classification accuracy detecting beticola metabolite analysis revealed metabolites altered host part successful defense response dopa hydroxyjasmonic acid beta glucoside pantothenic acid feruloylquinic acid accumulation glucosylvitexin resistant cultivar suggests acts constitutively produced protectant study establishes proof concept unbiased presymptomatic non invasive detection system presence beticola test needs validated larger set genotypes scalable level crop improvement program aiming speed selection resistant cultivars sugar beet untargeted metabolic profiling valuable tool identify metabolites correlate hyperspectral data
dynamics belief knowledge one major components autonomous system able incorporate new pieces information order apply rationality result belief dynamics theory various practical problems generalized two respects first allow certain part belief declared immutable second belief state need deductively closed generalization belief dynamics referred base dynamics presented paper along concept generalized revision algorithm knowledge bases horn horn logic stratified negation show knowledge base dynamics interesting connection kernel change via hitting set abduction paper show techniques disjunctive logic programming used efficient deductive database updates key idea transform given database together update request disjunctive datalog logic program apply disjunctive techniques minimal model reasoning solve original update problem approach extends integrates standard techniques efficient query answering integrity checking generation hitting set carried hyper tableaux calculus magic set focused goal minimality
decidualization endometrial stromal cells important feature implantation pregnancy molecular mechanism underlying decidualization remains unclear particularly regarding microrna mirna mir regulation process present study revealed temporal spatial distribution mmu mir mouse uterus early pregnancy reverse transcription quantitative polymerase chain reaction situ hybridization addition primary stromal cells isolated mouse uterus used explore role mmu mir decidualization results demonstrated mmu mir highly expressed stromal cells pregnancy upregulated implantation sites addition mmu mir strongly expressed decidualization indicates may serve role decidualization stromal cells based existing reports mmu mir participates apoptosis therefore present study investigated effects apoptosis primary endometrial stromal cells results indicated overexpression mmu mir may induce apoptosis stromal cells studies regarding underlying mechanism target genes mmu mir screened bioinformatics analysis confirmed cell lymphoma anti apoptotic gene target mmu mir determined using reporter gene assay conclusion present study suggested mmu mir participates decidualization endometrial stromal cells mice thereby serving key role pregnancy
article demonstrates loss personal control leads increase self regulatory behavior occurs loss control puts consumers deficit relative one major lessons learn childhood control outcomes actions deficit triggers compensatory process focused following lessons consumers believe learned childhood exerting self regulation another major lesson parents emphasize consumers engage self regulatory behavior compensate loss personal control however consumers believe parents emphasized self regulation less strongly childhood believe parents permissive style loss control reduce self regulatory behavior findings implications know effects childhood experiences adult consumer behavior importance individuals beliefs childhood experiences determining adult behavior consequences low personal control antecedents self regulatory behavior
background previous studies patients diagnosed social anxiety disorder sad reported changed patterns resting state functional connectivity network fcn prefrontal cortices prefrontal amygdalar striatal regions using graph theory approach study explored modularity based community profile patterns inter intra modular communication fcn sad methods total sad patients healthy controls functional magnetic resonance imaging fmri data acquired resting state subjected graph theory analysis results within module degree score hub region total hub regions ranked using participation coefficient named left middle temporal gyms impaired sad compared proportional severity clinician scored patient reported functional impairment sad limitations participants included study undergraduate students early mid conclusions study showed importance functional communication left middle temporal gyros opercular insular subcortical regions better objective functioning lesser subjective disability sad
objectives dissipative energy loss derived vector flow mapping represents viscous dissipation turbulent blood flow aimed determine left ventricular energy loss patients end stage renal disease esrd methods patients esrd preserved ejection fraction consisted group receiving peritoneal dialysis group receiving hemodialysis group receiving preparation dialysis initiation examined echocardiography group healthy control participants examined well vector flow mapping analysis performed apical chamber view calculate energy loss diastole systole left ventricle results conventional transthoracic echocardiography energy loss calculations successfully performed cases controls patients esrd significantly higher diastolic energy loss median interquartile range versus higher systolic energy loss versus significant difference diastolic energy loss peritoneal dialysis preparation groups found versus patients esrd log transformed diastolic energy loss significant association peak early diastolic transmitral flow velocity peak early diastolic transmitral flow velocity peak early diastolic mitral annular flow velocity ratio mass index heart rate conclusions impaired blood flow efficiency detected patients esrd using dissipative energy loss derived vector flow mapping energy loss value could novel parameter evaluating ventricular workload uremic hearts terms fluid mechanics
paper presents main approaches marine current turbine emulator development three design phases developed first one based emulated marine current turbine coupled load break replaced electrical generator second phase finally third structure conceived additional active load used inertial tests
study design report new technique objective introduce new method precise correction controlling ankylosing spondylitis kyphosis summary background data exact angle method excellent calculating pedicle subtraction osteotomy angle difficult perform surgery study precise rod bending technique proposed new method precise correction controlling ankylosing spondylitis kyphosis illustrative cases methods preoperative plan using exact angle method exact osteotomy angle level determined prepared using whole spine lateral ray film precise contoured rod imitating predicted spine correction obtained using lateral spine ray film actual size trunk rod model disinfected used precisely controlling kyphosis correction ankylosing spondylitis patients good cervical spine hip joints results four ankylosing spondylitis kyphosis patients successfully corrected using precise bending rod technique mean age years mean operative time minutes min mean volume bleeding average follow period months patients regained sagittal balance ssvl predicted ostetomy degree accurate within degrees compared achieved degree osteotomy site complications occurred surgery conclusions precise rod bending technique simple effective method precise correction kyphosis caused ankylosing spondylitis surgical result corresponded preoperative planning
background previous evidence healthy subjects suggested functional polymorphisms gskb fxr interact regulating mood emotional processing attempted replicate interaction primarily manic depressive dimensions mood disorder patients secondarily schizophrenia patients diagnosis age onset methods symptom dimensions derived comprehensive assessment symptoms history items rated lifetime acute episodes stabilized interepisode intervals patients schizophrenia bipolar disorder eastern quebec kindred study linear mixed effect models symptom dimensions included main interaction fixed effects obtained taqman genotypes polygenic random effect distribution lifetime best estimate dsm diagnosis kindred members studied versus genotype polytomous logistic model results mood disorder patients level mania acute stabilized periods depression stabilized periods positively associated gskb fxr allele carriers bonferroni corrected interaction respectively two polymorphisms explained mania variance interepisode depression variance association observed neither schizophrenia patients psychotic dimension mood disorder patients interaction diagnosis distribution driven decreasing prevalence recurrent major depression also carriers limitations sample size limited power sufficient detect tested interaction effect replication sample conclusions replicate affective patients interaction fxr gskb polymorphisms regulating mood dimensions
one operational amplifier amp negative feedback traditional zero potential circuit could access one element two dimensional resistive sensor array shared row column fashion suffered crosstalk problem non scanned elements bypass currents injected array non scanned electrodes zero potential firstly suppressing crosstalk problem designed novel improved zero potential circuit one amp negative feedback sample total bypass current calculate precision resistance element tested ebt improved setting non scanned electrode zero potential circuit nse zpc given example analyzing verifying performance improved zero potential circuit secondly nse zpc improved nse zpc effects different parameters resistive sensor arrays readout circuits ebt measurement accuracy simulated multisim thirdly part features improved circuit verified experiments prototype circuit followed results discussed conclusions given experiment results show improved circuit though requires one amp one resistor one sampling channel access ebt resistive sensor array accurately
digital low dropout regulator ldo drawn significant attention recently low voltage operation process scalability however tradeoff current efficiency transient response speed limited applications brief coarse fine tuning technique burst mode operation proposed ldo voltage undershoot overshoot detected coarse tuning quickly finds coarse control word load current located large power mos strength high sampling frequency fixed time fine tuning reduced power mos strength sampling frequency regulates ldo desired output voltage takes steady state operation high accuracy current efficiency proposed ldo verified cmos process active area measured voltage undershoot overshoot respectively load steps edge time quiescent current figure merit achieved moreover reference tracking speed
child sexual abuse csa global public health problem major consequences individual child society earlier swedish study showed school nurses initially talk mention csa one form child abuse child receive adequate support disclosure precondition dependent available person prepared listen aim study explore ability school nurses detect support sexually abused children secondary analysis focus group interviews school nurses thematic analysis performed results showed school nurses avoided addressing csa due arousal strong emotions ambivalence complicated disclosure process order detect csa support abused children attentiveness sexual abuse possible cause physical mental illhealth crucial
study objective determine awareness access knowledge proper use emergency contraception pills ecps among uninsured adolescents design anonymous surveys used assess awareness knowledge access ecps setting mobile primary care clinic san francisco bay area participants patients uninsured adolescents aged participants currently homeless past year ethnicity asian hispanic pacific islanders white mixed ethnicity interventions post survey completion patients received one one minute dedicated ecp education main outcome measures awareness knowledge access ecps results study population participants years old years old mean age years women young women reported higher rates hearing emergency contraception young men many incorrectly identified uncertain ecps abortion pill could used regular birth control prevent sexually transmitted infections women men aged older correctly answered could obtain counter know males could receive use partner incorrectly selected infertility side effect false impression taken within day unprotected sex conclusions uninsured adolescents high rates ecp awareness low ecp knowledge adolescents need ecp education alleviate misconceptions increase practical knowledge specifically education male access side effects counter availability young men women hour window use
paper presents new design low cost two channel type thermocouple interface circuit microcontrollers interface circuit enables connecting microcontroller make accurate temperature measurements degree celsius degree resolution usage microcontrollers computational capabilities proposed make adaptive self calibration designed interface circuit capabilities also used solve two major problems associated thermocouple signal measurement thermocouple non linearity problems thermocouple reference junction problems
recent research begun examine impact cultural mixing human psychology conducted four experiments examine influence intrusive cultural mixing implicit intergroup attitudes results indicated intrusive cultural mixing augmented implicit prejudice toward intruding foreign cultural group study heightened implicit prejudice partially mediated boycotting behavior provoked intrusive cultural mixing study cultural identification study multicultural orientation study moderated influence intrusive cultural mixing implicit prejudice individuals highly identified heritage culture exhibited weak multicultural orientation manifested enhanced implicit prejudice findings extend understanding influence cultural mixing
nanostructured cobalt oxide coo regarded great interest catalysis gas sensors energy conversion storage paper reported water vapor assisted thermal oxidation approach scalable synthesis free standing coo nanowires controlled size crystallization spatial density thermodynamic calculation carried understand fundamental mechanism water vapor assisted nanowire formation process first time found incorporation water vapor growth system modified nanowires formation pathway cobalt hydroxide recognized take critical intermediate role growth proposed mechanism verified understanding influence various growth parameters thermal oxidation process product morphology observed feeding rate water vapor type oxygen source critical influence spatial density coo nanowires temperature shows dominant effect product morphology finally representative coo products characterized composition optical magnetic properties study accumulates deeper understanding fundamentals water vapor assisted thermal growth metal oxide nanostructures successfully provides facile approach scale production coo nanowires future applications elsevier rights reserved
review necessary explorations performing surgical procedure stress urinary incontinence sui explorations must meet three objectives affirm diagnosis sui diagnosis sui easy pure half associated overactive bladder symptoms useful indispensable tools affirm diagnosis besides well conducted examination symptom questionnaires usp mhu impact quality life question iciq voiding diary days clinical examination performed good conditions allowing visualize leaks related stress test cough abdominal straining checking absence others urinary disorders may alter indication prognosis low stream often underestimated patient genital prolapse may asymptomatic essential tools evaluate disorders uroflowmetry post voiding residual measure clinical examination check possible genital prolapse urodynamic study case urinary disorders associated sui complex situation specify mechanism incontinence urethral hypermobility urethral mobility cough abdominal straining simulation effect sub urethral tape support test witch positive makes disappear leaks
dual assignment clustering dac recently proposed computer vision shown yield improved accuracy action clustering tasks key idea dac consider another view different original features set samples exploit statistical correlation cluster assignments two views however existing optimization heuristic mainly due difficulty combinatorial optimization hard cluster assignment paper introduce novel dac optimization algorithm based probabilistic soft treatment proposed objective function incorporates goodness clustering view correlation two views principled theoretically sound fashion also propose lower bound maximization technique admits fast per iteration solutions also guarantees convergence local optimum superiority proposed approach existing methods demonstrated several activity video datasets elsevier inc rights reserved
hour code one hour introduction computer science organized code org nonprofit dedicated expanding participation computer science study investigated impact hour code students attitudes towards computer programming knowledge programming sample undergraduate students two universities selected participate participants completed hour code tutorial part undergraduate course electronic questionnaire implemented pre survey post survey format gauge change student attitudes toward programming programming ability findings indicated positive impact hour code tutorial students attitude toward programming however students programming skills significantly change authors suggest deeper alignment marketing teaching content would help sustain type initiative exemplified hour code
professional consultancy services provided construction management consultants cmc important supplements clients management project execution however cmcs services carefully managed bring salient contributions paper aims empirically examine clients delegation cmcs affects client consultant capability integration project management processes based comprehensive literature review conceptual capability integration model developed triangulated approach adopted collect qualitative quantitative data social network analysis sna case analysis provide exploratory evidence capability integration model partial least square based structural equation modeling pls sem analyses tested model hypotheses statistically results suggest clients cmcs capabilities contribute project management processes although clients contributions significant delegating responsibilities cmcs better utilizes capabilities time restrict clients contributions theoretically findings provide empirical support theory temporal project organization map client consultant collaboration interface practice clients better utilize cmcs capabilities designing appropriate responsibility delegation systems based revealed capability integration mechanism american society civil engineers
purpose low testosterone common men renal disease increases risk death dialysis studied serum testosterone transplantation correlated patient graft outcomes materials methods identified serum samples collected frozen time transplantation male recipients primary kidney transplants done years ago institution recipients sufficient serum determine total testosterone analyzed contingency outcomes fisher exact test continuous values student test survival gehan breslow wilcoxon test results mean patient age years range living cadaveric donors recipients diabetes mean serum testosterone range testosterone low less patients age correlate testosterone low testosterone recipients worse year patient survival year patient survival year graft survival year graft survival survival curves showed significantly worse patient survival graft survival low testosterone multivariable analysis low testosterone independently associated patient death graft loss conclusions low testosterone transplantation associated patient death graft loss due causality testosterone therapy may impact survival without causality low testosterone may still marker posttransplant risk
involvement suprafacial intrafacial oxygen species catalytic combustion methane faceted cobalt spinel systematically examined function temperature conversion clear cut coo nanocubes uniform size synthesized using hydrothermal method characterized xrd tem xrf tpsr ssitka techniques experimental results corroborated first principles thermodynamic dft molecular modeling providing rational framework detailed understanding origin different redox comportment catalyst varying temperature mechanistic implications three temperature conversion stages methane oxidation reaction distinguished depending involvement adsorbed lattice oxygen redox state catalyst stoichiometric surface region degrees degrees featured dominant suprafacial langmuir hinshelwood mechanism methane oxidation region slightly defected surface degrees degrees oxygen vacancies partially refilled catalyst significantly reduced methane combusted according mars van krevelen scheme molecular modeling revealed suprafacial ads adoxygen species active delta intrafacial surf surface sites delta oxidation surface state diagrams three distinguished conversion regions constructed elucidate catalyst thermodynamic behavior conditions shown activity cobalt spinel maintained redox autotuning catalyst dynamic adjustment uneven participation suprafacial intrafacial oxygen species methane oxidation actual reaction conditions factors important structural mechanistic consequences catalytic combustion cobalt spinel related systems controlling sustainable versus stoichiometric turnovers also prevalence coexistence langinuir hinshelwood mars van krevelen mechanisms reaction progress
cytoskeleton provides structure active component cell function several neurodegenerative disorders evidence cytoskeletal collapse cytoskeletal proteins specifically implicated pathogenesis parkinson disease degeneration dopaminergic neurons hallmark many factors may determine resilience neurons aging stress report human microtubule actin cross linking factor gene macf downstream target biochemical pathways significantly associated nuclear families significant allelic association observed observed association analysis trend test allelic test observed macfb isoform macfa isoform expressed neurons six human postmortem brains caenorhabditis elegans system used explore effect altered macfb neurons knockdown knockout macfb orthologue vab resulted selective loss neurons validated macf risk candidacy findings strongly suggest macfb may contribute genetic etiology mechanistic causation
vaginal dryness associated symptoms may occur women age frequent burden menopause north american menopause society recommends long acting non hormonal vaginal creams first line therapy new type creams developed remifemina feuchtcreme austria germany hormone free cream contains hamamelis virginiana distillate well established vaginal cream ingredients explored physical function tolerability open interventional clinical trial postmenopausal women years median treated vaginal dryness using cream daily days reported symptoms first last application physician assessed tolerability local physical function patients completed study local physical function significantly improved dryness baseline mean normal moisture level average first last application subjective assessment feeling vaginal dryness showed significant improvement times onset duration feeling moisturized reported min application women reported vaginal dryness baseline patients reported dryness first application end investigation cream seen application site tolerability assessments reveal relevant change time four adverse events patients serious mild intensity urinary urgency diarrhoea mild spotting first application latter caused dry surface applicator avoided moisturizing surface applicator subsequent applications conclusion study results indicate well tolerated long acting function new vaginal moisturizing cream clinical research patients follow
background purpose study determine anti melanogenic anti oxidant properties gaillardia aristata flower extract gae methods melanogenesis inhibition gae investigated cultivated cells human skin model cultivated cells melanogenesis regulatory effect gae evaluated using melanin content intracellular tyrosinase activity anti oxidant characteristics addition expression melanogenesis related proteins determined western blot assay real time pcr results gae reduced amount melanin normal human epidermal melanocyte cells suppressed intracellular tyrosinase activity dose dependent pattern also gae significantly decreased expression melanogenesis related proteins microphthalmia associated transcription factor tyrosinase tyrosinase related protein dopachrome tautomerase real time pcr results revealed regulation mrnas proteins gae possessed anti oxidant characteristics free radical scavenging capacity reducing power three dimensional human skin model gae applied hyperpigmented skin significantly increased degree skin lightening within weeks treatment safety gae human skin confirmed conclusions results indicate potential gae use suppressing skin pigmentation proposed gae new candidate anti melanogenic antioxidant agents could used cosmetic skin care products
authors investigated effects valence arousal memory using dual process model quantifies recollective nonrecollective components recall without relying metacognitive judgments separate results showed valenced words increased reconstruction component nonrecollective retrieval relative neutral words addition authors found positive valence increased recollective retrieval comparison negative valence whereas negative valence increased nonrecollective retrieval relative positive valence latter effect however depended arousal reliable arousal high present findings supported notion emotional valence conceptual gist affected nonrecollective retrieval subjects recall protocols clustered valence results challenge hypothesis valence affects recollection clarify previous inconsistent findings effects emotion memory accuracy brain activity
creep curve geosynthetic assays requires long time socalled conventional tests reduce time used sim teste stepped isothermal method known accelerated test paper presents results accelerated conventional tests assess creep geotextile non woven polyester short fiber compared literature results showed less variability temporal range accelerated creep curves
era rapidly developing network computer network technology attain swift violent development well popularized applied background network security increasingly focused people kinds ways sought people solve network security problems firewall technology technology effectively guarantee network security also internal network security external network defense technology isolate internal security important part network security agencies paper firewall technology parts firewall products studied find problems unique ideas accordingly proposed finally methods changing shortcomings firewall invasion hopefully firewall technology better develop also better protect network security futures
background antenatal maternal cortisol levels associate alterations amygdala structure associated emotion regulation offspring however offspring brain behavior commonly assessed years birth timing maternal influences unclear study aimed examine association antenatal maternal depressive symptomatology neonatal amygdala volume microstructure thus establish evidence transgenerational transmission vulnerability affective disorders prenatal development methods study recruited asian mothers weeks pregnancy assessed maternal depression weeks gestation using edinburgh postnatal depression scale structural magnetic resonance imaging diffusion tensor imaging performed nonsedated day old newborns analyzed extract volume fractional anisotropy axial diffusivity values amygdala results adjusting household income maternal age smoking exposure postconceptual age magnetic resonance imaging birth weight found significantly lower fractional anisotropy axial diffusivity volume right amygdala infants mothers high compared low normal edinburgh postnatal depression scale scores conclusions results reveal significant relation antenatal maternal depression neonatal microstructure right amygdala brain region closely associated stress reactivity vulnerability mood anxiety disorders findings suggest prenatal transmission vulnerability depression mother child interventions targeting maternal depression begin early pregnancy
analysis penalized stokes problem variable viscosity formulation coupled convection diffusion equations presented article models interaction highly viscous fluid variable viscosity immersed moving deformable obstacles indeed quite common couple poisson equations diffusion transport equations plasma physics fluid dynamics vorticity formulations study complex fluids requires consider together stokes problem complex moving geometry convection diffusion equations main result paper shows existence uniqueness solution equations system regularity estimates show solution penalized problem weakly converges toward solution physical problem numerical simulations fluid mechanics computations context also presented order illustrate practical aspects models lung cells surrounding heterogeneous fluid porous media flows among main original aspects present study one highlight non linear dynamics induced coupling tracking time dependence domain
type regulatory cells play pivotal role restraining human cell responses toward environmental allergens protecting allergic diseases still precise molecular cues underlie transcriptional functional specification remain elusive show cytokine activin instructs generation cells express cell associated molecules inducible cell costimulator icos lymphocyte activation gene protein lag cdb exert strongly suppressive functions toward allergic responses induced naive vivo primed human helper cells moreover mechanistic studies reveal activin signaling induces activation transcription factor interferon regulatory factor irf along environmental sensor aryl hydrocarbon receptor forms multipartite transcriptional complex binds icos promoter elements controls gene expression human cells fact irf silencing abrogates activin driven icos regulation impairs suppressive functions human activin induced like act itr cells importantly using humanized mouse model allergic asthma demonstrate adoptive transfer human act itr cells preventive therapeutic protocols confers significant protection cardinal asthma manifestations including pulmonary inflammation overall findings uncover activin induced irf aryl hydrocarbon receptor ahr dependent transcriptional network generates suppressive human cells may harnessed control allergic diseases
robust control technique proposed address problem trajectory tracking autonomous ground vehicle agv technique utilizes fractional order proportional integral derivative fopid controller control non holonomic autonomous ground vehicle track behaviour predefined reference path two fopid controllers designed control agv inputs inputs represent torques used order manipulate implemented model vehicle obtain actual path implemented model non holonomic autonomous ground vehicle takes consideration kinematic dynamic models additional particle swarm optimization pso algorithm used optimize fopid controllers parameters optimal tuned parameters fopid controllers minimize cost function used algorithm effectiveness validation proposed method verified different patterns reference paths using matlab simulink software package stability fractional order system analysed also robustness system conducted adding disturbances due friction wheels vehicle motion obtained results fopid controller show advantage performance technique terms minimizing path tracking error complement path following
neurocognitive impairment found marked feature bipolar disorder also early phase illness longitudinal course neurocognitive functioning however remains sparsely investigated aims study investigate course neurocognitive function degree neurocognitive change stability observed also individual level forty two patients comparable healthy controls assessed baseline one year follow compared healthy control group patients perform significantly poorer baseline follow across neurocognitive domains neurocognitive subtests neurocognitive impairment remained stable patients baseline follow group level investigating individual trajectories indicative relatively stable course neurocognitive functioning early phase
ethnopharmacological relevance phaleria macrocarpa scheff boerl well known folk medicinal plant indonesia traditionally macrocarpa used control cancer impotency hemorrhoids diabetes mellitus allergies liver hearth disease kidney disorders blood diseases acne stroke migraine various skin diseases aim study purpose study determine situ cytotoxicity effect macrocarpa fruit ethyl acetate fraction pmeaf underlying molecular mechanism cell death materials methods mda cells incubated pmeaf cell cycle viability examined using flow cytometry analysis apoptosis determined using annexin assay also fluorescence microscopy apoptosis protein profiling detected raybio human apoptosis array results staining flow cytometric analysis mda cells treated pmeaf showed apoptotic cell death cell cycle analysis flow cytometry analysis revealed accumulation pmeaf treated mda cells phase cell cycle moreover pmeaf exert cytotoxicity increased ros production mda cells consistently stimulated loss mitochondrial membrane potential awm induced apoptosis cell death activation numerous signalling proteins results apoptosis protein profiling array evidenced pmeaf stimulated expression pro apoptotic proteins bax bid caspase caspase cytochrome smac suppressed anti apoptotic proteins bcl bcl xiap survivin mda cells conclusion results indicated pmeaf treatment induced apoptosis mda cells intrinsic mitochondrial related pathway participation pro anti apoptotic proteins caspases phases cell cycle arrest mediated mechanism
backgroundasthma cell driven inflammatory disease major public health concern cis acting element rad hypersensitive site rhs locus control region essential regulation cytokine genes however role allergic airway inflammation underlying molecular mechanisms regulation rhs poorly understood objectivewe sought understand role rhs development allergic airway inflammation molecular mechanism cytokine expression methodswe used ovalbumin induced allergic inflammation model rhs deficient mice examine role rhs process examine molecular mechanism rhs cytokine expression used dna affinity chromatography mass spectrometry quantitative pcr elisa intracellular cytokine staining chromatin immunoprecipitation immunoprecipitation resultsdeletion rhs caused dramatic resistance allergic airway inflammation rhs recruited transcription factors gata satb irf play important roles expression three cytokine genes rhs deficiency caused inhibition transcription factor induced cytokine gene expression conclusionrhs critical regulatory element allergic airway inflammation coordinate regulation cytokine genes recruiting gata satb irf
although patients lower urinary tract symptoms constitute large still growing population understanding bladder detrusor muscle physiology remains limited understanding interactions detrusor smooth muscle cells bladder cell types interstitial cells may significantly contribute coordinating modulating detrusor contractions represents considerable challenge computer modeling could help elucidate properties difficult address experimentally therefore developed silico models detrusor smooth muscle cell interstitial cells coupled gap junctions models include major ion conductances transporters described smooth muscle cell interstitial cells literature model normal detrusor muscle smooth muscle cell interstitial cells coupled gap junctions completely reproduced experimental results obtained detrusor strips presence several pharmacological interventions ryanodine caffeine nimodipine whereas model smooth muscle cell alone without interstitial cells failed reproduce experimental results next model overactive bladder highly prevalent clinical condition men women increasing incidence older ages produced modifying several processes reported previously reduction release ryanodine receptors reduction dependent conductance augmented gap junctional coupling model also able reproduce pharmacological modulation overactive bladder conclusion model bladder detrusor muscle developed reproduced experimental results obtained normal overactive bladder preparations results indicate non smooth muscle cells detrusor interstitial cells contribute significantly contractile behavior bladder detrusor muscle neglected model suggests reduced release ryanodine receptors dependent conductance together augmented gap junctional coupling might play major role overactive bladder pathogenesis
sulphur dioxide important preservative wine presence foods cause allergies given impetus research alternatives aim study reduce levels sulfite wine production using mixtures lysozyme dimethyl dicarbonate examine influence levels volatile biogenic amines vinifications carried using lysozyme dimethyl dicarbonate dmdc mixtures different concentrations results compared control vinification mixing low concentrations lysozyme dmdc reduced concentration biogenic amines histamine tyramine putrescine cadaverine phenylethylamine spermidine spermine general total concentration volatile amines dimethylamine isopropylamine isobutylamine pyrrolidine ethylamine diethylamine amylamine hexylamine higher sample fermented concentrations amines secondary amino groups dimethylamine diethylamine pyrrolidine higher sample fermented fermented dmdc lysozyme mixture preservatives preservative wine total amine concentration biogenic volatile amines higher rest treatments lysozyme lysozyme mixed reduced formation biogenic amines given antioxidant activity use preservative mixture seems advisable
feasibility longer spans relies successful implementation new high strength light weight materials carbon fiber reinforced polymer cfrp first dimensionless equilibrium equation corresponding compatibility equation established develop cable force equation cable displacement governing equation suspension cables respectively subsequently inextensible cable case introduced formula irvine parameter considered physical interpretation well relationship chord gravity stiffness presented influences increment cable force displacement lambda load ratio analyzed respectively based assumptions analytical formulations span suspension cable utilized example verify proposed formulation responses relative increment cable force cable displacement symmetrical asymmetrical loads studied presented case deflections resulting elastic elongation solely due geometrical displacement analyzed lower elastic modulus cfrp finally comparison steel cables influences cable force equation governing displacement equation span rise span ratio analyzed moreover influences static performance suspension bridge span sag ratios also analyzed substantive characteristics static performance super span cfrp suspension bridges clarified superiority characteristics cfrp cable structure demonstrated analytically
drivers claim use cell phones benefits getting work done increase productivity sanbonmatsu strayer behrends medeiros ward watson press however individuals use cell phones driving may likely rely reconstructive processes memory due divided attention making susceptible errors yielding ironic effect multitasking fact may diminish productivity rather increase test possibility present study included three within subject conditions single task driving highfidelity simulator single task memory including encoding retrieval using deese roediger mcdermott false memory paradigm deese roediger mcdermott dual task combination driving memory tasks effects divided attention working memory bidirectional impairing driving episodic memory performance likely due competition limited resources needed successfully maintain task goals related driving memory alone specifically dual task conditions participants became increasingly reliant reconstructive error prone processes memory high levels false recall taken together results indicate productivity illusion associated distracted driving individuals wrongly believe combining cell phones driving make productive results discussed relation theories working memory domain free ability maintain task goals avoid distractions whether interference occurs traditional lab tasks applied settings highlighting value converging evidence sharpening theories attention
inflammatory bowel disease ibd includes set pathologies result deregulated immune response may affect portion gastrointestinal tract prevalent defined forms ibd crohn disease ulcerative colitis although etiology ibd well defined suggested environmental genetic factors contribute disease development interaction two factors trigger pathology diet medication use vitamin status smoking bacterial infections proposed influence contribute onset development disease susceptible individuals infection pathogenic bacteria key factor influence development severity disease present comprehensive review studies performed human mice susceptible ibd supports notion infection bacterial pathogens salmonella could promote onset ibd due permanent changes intestinal microbiota disruption epithelial barrier alterations intestinal immune response infection
construction one hazardous industries study analyzes occupational risk focuses specifically question perception risk based sample construction workers three countries spain peru nicaragua spite sharing language spanish different socioeconomic levels model used study based psychometric paradigm results survey using questionnaire indicate sample population separated two different clusters characterized either high low perception risk authors attempted establish link level perceived risk different socio demographic variables outcome training variable significantly altered perception risk finding well various aspects risk perception different nations discussed conclusions study provide interesting guidelines risk management construction industry example increase number hours worker safety health training nationality workers appear affect worker risk perception
protein function identification remains significant problem solving problem molecular functional level would allow mechanistic determinant identification amino acids distinguish details functional families within superfamily active site profiling developed identify mechanistic determinants dasp dasp developed tools search sequence databases using active site profiling tulip two level iterative clustering process introduced iterative divisive clustering process utilizes active site profiling separate structurally characterized superfamily members functionally relevant clusters underlying tulip observation functionally relevant families curated structure function linkage database sfld self identify dasp searches clusters containing multiple functional families tulip iteration produces candidate clusters evaluated determine self identifies using dasp deemed functionally relevant group divisive clustering continues structure either functionally relevant group member singlet tulip validated enolase glutathione transferase structures superfamilies well curated sfld correlation strong small numbers structures prevent statistically significant analysis tulip identified enolase clusters used dasp genbank searches identify sequences sharing functional site features analysis shows true positive rate false negative rate maximum false positive rate measure performance analysis enolase search results comparison gemma sci phy demonstrate tulip avoids division problem methods mechanistic determinants enolase families evaluated shown correlate well literature results
numerous long span suspension bridges built worldwide past decades ensure safety bridges users bridge service life several bridges equipped structural health monitoring systems shmss measure dynamic bridge responses various loading types site integrating shms damage detection technology condition assessment bridges become new development trend recent studies proven stress influence line sil based damage indices achieve excellent damage detection performance long suspension bridge however accurate prompt manner identifying sil long suspension bridge important facilitate development sil effective damage index identifying sil field measurement data service conditions several advantages traditional static loading test study proposes develops new sil identification method integrating least squares solution weighted moving average wma based measured train information corresponding train induced stress time history efficacy proposed method validated application tsing bridge tmb good agreement identified baseline sils typical diagonal truss member verifies effectiveness proposed method furthermore robustness testing performed identifying sil basis information different trains train induced stress responses identifying sil different types bridge components results indicate feasibility application proposed approach sil identification long span bridges
china setting increasingly ambitious greenhouse gas targets backing wide array policies programmes successful china slowing eventually reversing growth greenhouse gas emissions depend significantly well policy implementation local regional levels article examines climate governance works china multi level governance structure explores chinese leadership taking climate change seriously nature policies programmes introduced steps taken promote local environmental innovation improve policy compliance copyright john wiley sons ltd erp environment
paper presents low power low noise cmos instrumentation amplifier intended use wireless bio potential monitoring system employs capacitively coupled topology achieve high power efficiency order depress noise chopper stabilized technique used transconductance boost technique introduced low noise amplifier lna mos transistors implemented lna biased subthreshold region supply voltage reduce power consumption moreover servo loop dsl implemented realize high pass corner electrode offset cancellation implemented cmos process front end circuit occupies draws capacitively coupled chopper stabilized instrumentation amplifier ccia draws input referred noise rms integrated khz results nef pef respectively whole circuit achieves cmrr psrr total input referred noise front end instrumentation amplifier including dsl rms integrated khz elsevier ltd rights reserved
using measurements valve activity distance two valves populations bivalves natural environmental conditions oysters bay arcachon france algorithm automatic detection spawning period oysters proposed brief spawning observations important aquaculture biological studies detection done visual analysis expert algorithm based fault detection approach works estimation velocity valve movement activity obtained calculating time derivative valve distance summarized description methods used derivative estimation provided followed associated signal processing decision making algorithm determine spawning velocity signal protection false spawning detection also considered analyzing simultaneity spawning study shown spawning population oysters living natural habitat sea automatically detected without human expertise saving time resources fault detection method presented brief also used detect complex oscillatory behavior interest control engineering community
intervention study compare effects health education alone health education plus advance provision emergency contraception pills knowledge attitudes female students university nigeria south east nigeria materials methods structured questionnaire used collect data february female students tertiary educational institution study group control group selected multistage sampling subsequently health education conducted among students addition pack containing tablets pills postinor given students study group three months intervention effects assessed survey using structured questionnaire employed baseline survey results knowledge significantly higher among study group controls post intervention attitudes also favorable post intervention survey among study group variables conclusion recommendation health education plus advance provision pills effectively improved knowledge attitudes among female students tertiary institutions health education alone promoted
aimthe effect health depreciation older people medical care demand well understood tried assess medical care demand length hospitalization impact profits result health depreciation methodsall participants underwent comprehensive geriatric assessment prospective cohort study tertiary hospital total cases september october investigated three sets qualitative response models constructed estimate impact older adults health depreciation multidisciplinary geriatric care services furthermore analyzed factors affecting composite end point rehospitalization within days admission emergency department within days patient death resultsgreater health depreciation elderly patients positively correlated greater medical care demand three major components defined health depreciation elderly adaptation function geriatric syndromes multiple chronic diseases admission better basic living functions shorter length hospitalization coefficient poisson regression coefficient order choice profit model coefficient binary choice profit model major determinants poor outcome male sex middle old age length hospitalization however factors correlated relatively good outcome functional improvement medical care services level disease education conclusionsan optimal allocation system selection cases multidisciplinary geriatric care required limited resources outcomes improve health promotion preventive care services geriatr gerontol int
design kind reducer first stage transmission cylindrical cam secondary stage transmission gear transmission multistage transmission reducer carried design calculation checking basis lateral cylindrical cam lateral transmission mathematical model conducted spiral curve analysis calculation numerical analysis software matlab import spiral curve data solidworks complete modeling cylindrical cam according structural design cylindrical cam complete reducer machine design virtual assembly gearless reducer stress analysis carried cam disk ansys mechanical analysis module solidworks designed meet working conditions conducted physical development based cad cae result showed design fast effective significantly shorten production cycle
introduction invasive fungal infections ifis important complication immunocompromised individuals particularly neutropenic patients hematological malignancies study aimed verify epidemiology diagnosis ifis patients hematologic problems tertiary hospital goiania brazil methods data patients involving cases ifis collected collected data included diagnosis methods demographics clinical characteristics vitro susceptibility different antifungal agents among cases classified proven ifi probable invasive aspergillosis detection galactomannan blood presence lung infiltrates radiographic images logistic regression analysis showed proven probable ifis associated increased risk death statistical analysis demonstrated age sex underlying disease independently associated risk death ifi patients results bloodstream isolates candida spp exhibited low minimum inhibitory concentrations mics antifungal agents tested voriconazole amphotericin lowest mics aspergillus spp fusarium spp fusarium spp showed least susceptibility antifungals tested amphotericin fluconazole itraconazole found inactive vitro acremonium kiliense fungus sensitive voriconazole conclusions considering high number ifi cases crude mortality rate could conclude ifis remain common infection patients hematological malignancies underdiagnosed ante mortem thus ifis monitored closely
spatiotemporal mining framework novel tool analysis marine association patterns using multiple remote sensing images data pretreatment algorithm design association rule mining pattern visualization paper outlines spatiotemporal mining framework abnormal association patterns marine environments including pixel based object based mining models within framework key issues also addressed data pretreatment phase propose algorithm extracting abnormal objects pixels marine surfaces construct mining transaction table object based pixel based strategies mining algorithm phase recursion method construct direct association pattern tree addressed asymmetric mutual information table recursive mining algorithm find frequent items knowledge visualization phase dimension attributes visualization framework used display spatiotemporal association patterns finally spatiotemporal association patterns marine environmental parameters pacific ocean identified results prove effectiveness efficiency proposed mining framework elsevier rights reserved
january severe haze episodes sweep across chinese cities attracted public concern interest home abroad addition physicochemical properties air pollutants bacteria thought responsible spread respiratory diseases various allergies attempted bacterial characterization submicron particles pmo severe haze episodes using high throughput sequencing real time quantitative pcr detecting system based samples collected january march nan china high bacterial concentration piv cells cells cells showed significant negative correlations sufficient sequencing depth phyla classes orders families genera classified bacterial community structure varied significantly different size fractions example holophagaceae acidobacteria showed fold higher abundance moreover functional categories bacterial species lactococcus piscium pseudomonas fragi streptococcus agalactiae pseudomonas cichorii may potentially responsible infections allergies also discovered source track analysis showed ambient bacteria mainly originated soils leaf surfaces feces results highlighted importance airborne microbial communities understanding concentration structure ecological health effects especially submicron particles haze episodes published elsevier
baby factories new systematic abuse structures promoting infant trafficking neo slavery exploitation young women unwanted pregnancies nigeria since practice first described growing rather abating paper reviews scientific literature along media reports critiques phenomenon children rights perspective children born baby factories denied various civil rights also suffer abuse baby factories consequence born places abuse classified immediate long term immediate abuse includes inadequate care repercussions denial birth registration illegal adoption murder long term delayed abuse may exposed includes health related consequences neglect death child labour prostitution sexual abuse organ trafficking recruitment child soldiers various factors thought drive baby factory phenomenon include poverty high infertility rates profitability local inter country adoptions programmes directed addressing root cause problem needed order eliminate infant trafficking also clear laws delineate inter country adoption infant trafficking need enacted importantly baby factories need recognised child trafficking routes copyright john wiley sons ltd
interest permanent magnet synchronous machines equipped fractional slot concentrated winding increasing recent years among others surface mounted machines spm widely selected motor manufacturers particularly attractive spoke type interior ipm machines nowadays machines often selected variable speed applications without precise positioning requirements taking advantage sensorless control algorithms nevertheless capability detect electrical rotor position without sensor also zero speed means techniques based high frequency signal injection enhancing feature requires proper machine design aim paper evaluate impact rotor stator modifications taking commercial motor reference geometry analysis two rotor structures spm ipm well stator tooth geometry variations pointed machine response due injection high frequency voltage significantly affected stator iron saturation finite elements simulations confirmed test two ipm motors manufactured different stator design
multi objective genetic algorithms gas one widely used techniques capability find solution problem multiple conflicting objectives like intrusion tection population based technique capable producing set non inferior solutions exhibit classification trade offs user capabil ity moga exploited generating optimal base classifiers ensembles thereof intrusion tection paper explores various mogas proposed literature along pros cons motivation use moga issues high lighted finally chapter highlights concluding remarks
introduction number genes known associated familial primary brain calcification pfbc causing called fahr disease syndrome scla pdgfb pdgfrb xpr systematic review analyse clinical radiological features reported genetically confirmal cases pfbc additionally reviewed pseudohypoparathyroidism close differential diagnosis pfbc clinical presentation also genetically determined methods performed medline search jan november publications confirmed mutations scla pdgfb pdgfrb xpr found twenty papers eligible cases second search done publications cases pseudohypoparathyroidism pseudopseudohypoparathyroidism found publications eligible cases results slca common gene involved cases included pfbc followed pdgfb pdgfrb statistically significant correlation found presence parkinsonism slca mutations headache pdgfb generalised tonic clonic seizures patients pseudohypoparathyroidism conclusion combine statistical analysis clinical inference suggest diagnostic algorithm based observations study help investigation patient neurological features brain calcification published elsevier ltd
current feedback operational amplifier cfoa allows implement kind circuit useful analogue signal processing applications however limited performance implementing nonlinear circuits way investigation highlights experimental results implementing multi scroll chaotic oscillator using commercially available cfoa chaotic oscillator based saturated nonlinear function snlf series show discuss frequency limitations generate scrolls khz khz finally conclude frequency limitations due nonideal characteristics cfoa based snlf block imposed
developed robust sensor mounting bridges rivers streams bridge mounted river stage sensors bmrss make periodic measurements distance sensor water level properly interpreted measurements provide river stage information data great importance society crucial effective flood forecasting traditional approach river stage measurement installation pipes rivers digging stilling wells construction attendant brick mortar infrastructure cost approach limits deployment larger rivers instances river stage data smaller tributaries even though data greatly enhance quality flood forecasting models outputs contrast bmrss units order magnitude less expensive allow widespread deployment bmrss units incorporate ultrasonic distance measuring module solar panel battery charge controller gps receiver recent years internet access commercial cellular networks become ubiquitous even rural areas bmrss units incorporate cell modems transmit data internet servers iowa flood center data ingested relational databases made available flood forecasting models information systems deployed operated bmrss units across iowa many several years continuously
purpose paper reviews adapts methodology guide methodology carrying cost benefit analysis prepared european commission specifically tailored assessment innovative rail freight service application context number potential service areas principally pan european europe spectrum service innovative rail freight concept transport low density high value ldhv goods methods methodology primarily based guide cost benefit analysis investment projects european commission cost definition takes input life cycle cost analysis applies series conversion factors benefits estimated considering user surplus difference generalised logistic costs glc borne transport logistics operators general freight transport service users using spectrum service glc connected preshift mode road traditional rail difference external costs generated freight transport activities connected externalities air pollution climate change noise accidents externalities stream processes nature landscape biodiversity losses soil water pollution congestion results adapted methodology proven capable representing multiple effects resulting theoretical introduction innovative rail service freight transport sector accounting differential impacts compared baseline scenario solutions logical articulation analysis flexible two specific estimation schemes estimation hoc unit parameters external costs hoc approach using glc proxies users surplus scenario introduction innovative service modifies modal split freight transport different solutions applied territorial contexts may also used evaluate types freight transport services provided unit data retrieved pertain site specific cost infrastructures average speeds rates different transport solutions costs personnel operating costs
spindle rotational accuracy one important issues machine tool affects surface topography dimensional accuracy workpiece paper presents machine vision based approach radial error measurement lathe spindle using cmos camera based image processing system present work precisely machined cylindrical master mounted spindle datum surface variations position captured using camera evaluating runout spindle circular hough transform cht used detect variations centre position master cylinder spindle rotation subpixel level sequence images radial error values spindle evaluated using fourier series analysis centre position master cylinder calculated least squares curve fitting technique experiments carried lathe different operating speeds spindle radial error estimation results presented proposed method provides simpler approach machine estimation spindle radial error machine tools
autism spectrum disorder asd hypothesized arise imbalances excitatory inhibitory neurotransmission imbalance studies demonstrated imbalance individuals asd also corresponding rodent models one neural process thought reliant balance gamma band activity gamma support arising observed correlations motor well visual gamma underlying gaba concentrations healthy adults additionally decreased gamma observed asd individuals relevant animal models though direct relationship gamma gaba concentrations asd remains unexplored study combined magnetoencephalography meg edited magnetic resonance spectroscopy mrs typically developing individuals individuals asd auditory cortex localized phase locked gamma compared resting superior temporal gyrus relative cortical gaba concentrations children adolescents adults children adolescents asd exhibited significantly decreased gaba creatine levels though typical gamma additionally children adolescents lacked typical maturation gaba concentrations gamma band coherence furthermore children adolescents asd additionally failed exhibit typical gaba gamma band coherence association altered coupling childhood adolescence may result gamma decreases observed adults asd therefore individuals asd exhibit improper local neuronal circuitry maturation childhood adolescence critical period gaba involved configuring circuit functioning provocatively novel line treatment suggested critical time window increasing neural gaba levels children adolescents asd proper local circuitry maturation may restored resulting typical gamma adulthood autism res international society autism research wiley periodicals inc
communication training become focus concern recent years veterinary medicine existing literature date indicates colleges veterinary medicine cvms implemented various communication training protocols present study focused evaluation communication training protocol implemented kansas state university ksu sample veterinary medical students across five cohorts protocol includes video review authentic client interactions feedback authentic clients small group communication training findings indicate targeted communication skills improved video review feedback small group communication training communication scores particularly affected students attention improving communication deficiencies second student client video baseline scores first student client video four specific areas using nonverbal communication setting expectations building rapport able clarify predictive overall performance second evaluation based results present study using videos authentic client interactions recommended valuable communication training teaching tool
objective current estimate prevalence rates mental disorder among canadian federal offenders required facilitate treatment delivery service planning method study determined prevalence rates major mental disorders among newly admitted male offenders entering federal correctional system canada data collected regional reception site consecutive admissions month period lifetime current prevalence rates estimated using structured clinical interview dsm axis disorders scid scid axis disorders scid degree impairment estimated using global assessment functioning gaf scale results disaggregated aboriginal ancestry results national prevalence rate current mental disorder highest rates alcohol substance use disorders however half participants met lifetime criteria major mental disorder alcohol substance use disorders antisocial personality disorder thirty eight percent met criteria current mental disorder one substance use disorders fifty seven percent offenders current axis mental disorder rated experiencing minimal moderate functional impairment based gaf indicating participants require intensive psychiatric services conclusions results underscore challenge posed canadian federal corrections providing necessary mental health services assist management rehabilitation significant percentage offender population mental health needs objectif une estimation actuelle des taux prevalence des troubles mentaux chez les detenus canadiens sous responsabilite federale est necessaire pour faciliter prestation des traitements planification des services methode etude determine les taux prevalence des troubles mentaux majeurs chez les detenus masculins nouvellement incarceres entrant dans systeme correctionnel federal canada les donnees ont ete recueillies chaque centre regional reception pour les admissions consecutives durant une periode mois les taux prevalence duree vie actuels ont ete estimes aide entrevue clinique structuree pour les troubles axe dsm scid entrevue clinique structuree pour les troubles axe scid degre incapacite ete estime aide echelle evaluation globale fonctionnement gaf les resultats ont ete desagreges par ascendance autochtone resultats taux prevalence national pour tout trouble mental actuel etait les taux les plus eleves etaient lies aux troubles utilisation substances alcool toutefois pres moitie des participants satisfaisaient aux criteres duree vie trouble mental majeur autre que les troubles utilisation substances alcool que trouble personnalite antisociale trente huit pour cent satisfaisaient aux criteres tant trouble mental actuel que trouble utilisation substances cinquante sept pour cent des detenus souffrant trouble mental actuel axe ont ete estimes presenter une incapacite fonctionnelle minimale moderee apres gaf indiquant que majorite des participants necessitent pas services psychiatriques intensifs conclusions ces resultats soulignent probleme pose aux etablissements correctionnels federaux canada qui concerne prestation services sante mentale necessaires pour aider gestion rehabilitation population des detenus ayant des besoins sante mentale
examine cultural organization collaboration mexican heritage sibling pairs ages videotaped participated puzzle construction activity half families recent connection rural practices limited schooling pueblo families half high schooling families connection middle class practices higher schooling children given previously constructed model parts construct another left alone every coders noted siblings coordinated either jointly engaged checking solo task collaboration organized either verbally nonverbally multiple means children pueblo families engaged jointly used nonverbal multiple means communication children high schooling families often worked solo task used talk communicate results linked practices indigenous american communities children learning observing pitching common elsevier ltd rights reserved
previous studies demonstrated investor sentiment affects trading behavior stock returns correlated seasons weather addition great deal evidence supports main systematic factors fama french three factor model study presents seasonal affective disorder sad model sad model examine influence season weather taiwan stock returns determine whether sad variables affect stock returns sad sad models include additional explanatory variable business cycle factor
understanding molecular interactions immune cells crucial drug development treat cancer autoimmune diseases characterizing molecular interactions use relevant living model system important processes receptor oligomerization clustering influence binding patterns developed protocol enable time resolved analysis ligand binding receptors living suspension cells different suspension cell lines weakly adhering cells tethered petri dishes help biomolecular anchor molecule antibody binding analyzed using ligandtracer protocol assay described report used characterize interactions involving eight cell lines experiments successfully conducted three different laboratories demonstrating robustness protocol various antibodies affinities kinetic rate constants obtained binding daudi ramos cells cell receptor jurkat cells gamma receptor transfected hek cells respectively analyzing binding rituximab cells resulted affinity similar values reported previously living cells however observed heterogeneous behavior rituximab interacting cells knowledge described previously understanding complex interactions facilitated possibility characterize binding processes real time living immune cells provides chance broaden understanding binding kinetics relate biological function
geotextile filters used several geotechnical geoenvironmental applications regarding protection banks slopes erosion caused action waves materials employed revetments armour layers paper presents results large scale tests armoured slopes geotextile granular filters employed wave flume used tests three types nonwoven geotextiles conventional granular layer employed filters armour layer base soil slope armoured slope subjected impacts waves produced wave generator opposite channel slope pore pressures soil slope measured tests soil particles piped though filters entrapped geotextile collected total mass particle diameter measurements results obtained showed geotextile granular filters presented similar performance addition retention criteria available type geotextile filter application provided conservative results findings highlight importance development accurate testing techniques filter criteria designing armoured slopes geotextile filters elsevier ltd rights reserved
starting existing wind energy potential romania possibilities recovery use developing wind power parks farms appropriate areas paper presents research conducted globally also national level developing testing hydrostatic transmissions order use wind power plants instead existing mechanical transmission gear box results showed flexible dynamic behavior energy efficiency possibilities increasing energy efficiency mechanical energy conversion chain wind power electric power hydrostatic transmission offers advantages high power density increased dynamic adaptive capacity strong variation wind turbine speed required quasi constant speed electrical generator
paper present eeg detection system low cost portable popularization realized low cost mass brain health examination mobile phone software networking cloud eeg pattern recognition expert database main functions system include mobile phone control eeg data acquisition established expert system database eeg patterns eeg patterns connected internet matching key technologies portable eeg health examination expert system structured storage eeg data feature extraction construction knowledge database pattern matching also discussed researched paper
reuse programming language development open research problem many authors proposed frameworks modular language development frameworks focus maximizing code reuse providing primitives componentizing language implementations also open debate combining feature orientation modular language development feature oriented programming vision computer programming features implemented separately combined build variety software products however even though feature orientation modular programming strongly connected modular language development frameworks usually meant primarily feature oriented language definition paper present model language development puts feature implementation center describe implementation neverlang framework model evaluated several languages implementations paper state machine language used means comparison frameworks javascript interpreter implementation used illustrate benefits model provides elsevier ltd rights reserved
thermal behavior temperature rise important index electrical machine especially motor electrical vehicle element thermal circuit model electrical machine proposed companion paper paper thermal resistant proposed model derived detail paper prototype machine introduced verify accuracy proposed model items may cause calculation error analysis result shows model presented companion paper suitable use machine design certain accuracy
background american academy pediatrics recommends consideration ability confidence caregiver take care preterm infant discharge objective identify parental self efficacy measured infant care survey ics evolves preterm child neonatal intensive care unit nicu admission identify conditions associated caregiver confidence methods prospective cohort study involving parents infants weeks gestation enrolled days infant life parent infant demographic pregnancy nicu data collected parents responded ics enrollment enrollment ics scores compared one another using paired samples test assess change scores time conditions thought affect self efficacy compared enrollment change total ics scores assess correlations results total ics scores showed significant improvement enrollment comparing caregivers children home parents caregivers without previous children significantly lower ics scores enrollment however ics scores similar result profound improvement self efficacy amongst first time parents child nicu admission conclusion despite stress anxiety child nicu parental self efficacy likely significantly improve child hospitalization evident amongst first time parents suspect parental participation infant care formal educational opportunities contribute improvement confidence time
collection modis land surface temperature lst product publicly available user community compared collection modis lst product modis lst product refined bare soil pixels assessing accuracy modis lst product help facilitate use lst product various applications study present cross satellite comparison evaluate accuracy modis lst product mod bare soil surfaces various atmospheric surface conditions using aster lst product reference comparison modis lst product also used analysis absolute biases differences modis lst aster lst bare soil surfaces approximately two times less differences modis lst aster lst furthermore rmses bare soil surfaces modis lst significantly smaller modis lst results indicate accuracy modis lst product much better modis lst product recommend user community employs modis lst product applications international society photogrammetry remote sensing inc isprs published elsevier rights reserved
issues gender imbalance leadership long significant issue universities case across industries paper explores experiences seven females successfully achieved senior leadership positions regional university australia experiences women differ many ways certainly similarities challenges adversities faced perceptions allowed experience success leadership roles paper provides number recommendations women aspiring leaders higher education committing ongoing development taking opportunities presented developing resilience developing track record seeking support also recommendations institutions
work static corrosion behaviors alo composites without produced mechanical alloying plasma activated sintering pas investigated results showed main corrosion failure mode pitting higher static corrosion resistance alo composites second phase alo addition resulted increase phase interface large difference electron density matrix alo reinforcement made phase interface become corrosion weaknesses addition static corrosion weight loss rate reduced element could improve stability alo passivation film composite surface
patients inflammatory bowel disease constitute population special predisposition develop bacterial viral fungal infections latrogenic immunosuppression frequent contact healthcare facilities surgical interventions risk factors explain infections one main causes morbi mortality disease infections follow subtle paucisymptomatic evolution diagnosis management may become real challenge attending physician screening systematized considered differential diagnosis objective review provide update practical concise perspective knowledge regarding epidemiology prevention diagnosis treatment common infections elsevier espana rights reserved
chinese medicine recognized popular complementary medicine world abundance healing knowledge transmitted enriched generation generation well recorded archive chinese medical knowledge grown developed detailed theory philosophy together comprehensive subtle system diagnosis recently internet quite often used variety applications medical purpose provide real time platform independent access build share knowledge clinical diagnosis experiences knacks diseases treatments even prescriptions respect real need intelligent system chinese medical physician education chinese medicine evolved complex methods diagnosis treatment tailored individual subtle patterns disharmony allows treat fully manifest diseases also assist maintaining health balance prevent illnesses occurring ontologies become important mechanism build knowledge based systems role ontologies capture domain knowledge provide commonly agreed upon understanding domain advantages include sharing use knowledge better engineering knowledge based system respect acquisition verification maintenance paper propose unifying framework intelligent disease diagnosis system named cmds chinese medical diagnostic system medical ontology integrated system development methodologies implementation digestive health cmds uses web interface expert system technology act human expertise diagnose number digestive system diseases besides efficiently elicit knowledge digestive system domain experts construct medical ontology hybrid knowledge acquisition strategy proposed cmds provides truly precise analysis digestive system disease prototype system diagnose types diseases amongst species primary digestive system uses rules images various diseases satisfactory performance system proven could serve educational purpose act consultant role functionality extended whole body health system elsevier ltd rights reserved
two discriminant methods partial least squares discriminant analysis pls fisher discriminant analysis fda combined fourier transform infrared imaging ftiri differentiate healthy osteoarthritic articular cartilage canine model osteoarthritic cartilage developed two years anterior cruciate ligament acl transection one knee cartilage specimens sectioned thickness ftiri pls model developed spectral pre processing spectra extracted ftir images calculated pls discriminant accuracy prior fda principal component analysis pca performed decompose spectral matrix informative principal component matrices based different discriminant mechanism discriminant accuracy pca fda high convenience higher plsda healthy cartilage sample mis assigned two methods mentioned suggested integrated technologies ftiri pls especially ftiri pca fda could become promising tool discrimination healthy osteoarthritic cartilage specimen well diagnosis cartilage lesion microscopic level results study would helpful better understanding pathology osteoarthritics
well known electrostatic discharges ignite mixtures flammable gases air suspensions combustible dust air reason prevention electrostatic discharges essential part measures prevent explosions fires incendive electrostatic discharges occurred five cases various chemical plants incidents involved spark type electrostatic discharges leaking steam pipe spark type electrostatic discharges inside charging chute solid spark type electrostatic discharge whilst transferring solid powder bin led ignition powder propagating brush discharge pneumatic transfer solid caused severe electric shock process operator brush discharge inside electrostatic precipitator caused ignition aerosol hydrocarbon avoid explosions fires important prevent incendive electrostatic discharges occurring industrial facilities help managers chemical plants incidents presented form learning lessons including mechanism generation separation electrical charges mechanism electrostatic discharge root causes incident safety measures necessary avoid repetition published elsevier
recently social class rarely studied psychology taken account rather control demographic variable variable interest aim paper propose integrated review recent research social psychology examines social class influences psychological functioning behavior literature conceptualizes social class context socialization modulates access resources shapes individuals ways thinking feeling acting present three approaches respectively focus three distinct aspects social class context economic symbolic cultural resources describe resources impact attentional focus orientation towards self environment ways define oneself individual review supporting empirical evidence sustaining approaches discuss relevance indicators used measure social class income employment level education perceived rank finally argue experimental social psychology social class particularly needed allows manipulation processes identify mechanisms social class influences psychological functioning behavior
objectives assess knowledge attitude barriers emergency contraception among married women child bearing age methods quantitative cross sectional study conducted month period commencing march family practice clinics king khalid university hospital kkuh riyadh saudi arabia data collected using structured pretested questionnaire analyzed using spss version statistical software result total women enrolled study knowledge two ever used health care professionals least reported source information majority negative attitude toward available counter without prescription common barriers using concerns possible health effects two women considered religious belief major hindrance use conclusion awareness emergency contraception low among women saudi arabia health care professionals least reported source information cause concern findings reveal urgent need educate women keeping view social norms islamic values
parkinson disease progressive movement disorder multiple non motor symptoms although family genetic mutations account small proportion cases mutations provided several lines evidence pathogenesis mitochondrial dysfunction protein misfolding aggregation impaired autophagy lysosome system recently vesicle trafficking defect emerged potential pathogenesis underlying disease rab gtpases serving core regulators cellular membrane dynamics may play important role molecular pathway complex interplay numerous factors related genes might shed new light potential therapeutic strategies review emphasize important role rab gtpases vesicle trafficking summarize interactions rab gtpases different related genes
online multimedia social networks osns popular efficient medium millions users unfortunately wrong hands also effective medium spreading social malware propagation social botnet newly proposed multimedia social network threat stegobot masks crucial information digital image using technique known steganography stegobot works first infecting computer communicates stolen information could login passwords bank account details credit card numbers also efficiently utilizes advantage image steganography hide presence communication within image sharing behavior osns since social bots exhibit unobservable communication channels existing botnet detection mechanisms applied botnets paper present novel host based method detecting differentiating stegobot profiles also proposed method shows ability detect stegobot network traffic inherently different legitimate multimedia social network traffic best performance detection system demonstrated different social networks data set different evaluation metrics multiple aspects multimedia attributes proposed study help explore hidden communication structure botnet stegobot profiles mimic genuine users compromise vulnerable users social network using single view features alone difficult detect bot profiles well stegobot communications hence work multi feature approach considered also work attempts help network security experts forensic analysts understand stegobot communication key profiles inside malicious network
study introduces tool automatic analysis cohesion taaco freely available text analysis tool easy use works operating systems windows mac linux housed user hard drive rather internet interface allows batch processing text files incorporates classic recently developed indices related text cohesion study validates taaco investigating indices related local global overall text cohesion predict expert judgments text coherence essay quality findings study provide predictive validation taaco support notion expert judgments text coherence quality either negatively correlated predicted local overall text cohesion indices positively predicted global indices cohesion combined findings provide supporting evidence coherence expert raters property global cohesion local cohesion expert ratings text quality positively related global cohesion
paper describes vehicle simulation originally designed hybrid battery fuel cell short urban distances used estimate hybrid vehicle battery fuel cell hybrid system systems working together range simulation model function many mechanical physical variables depends vehicle also ground includes simulation elements make ecological scooter much driving system whose main element electric motor energy storage system whose main element acid lead battery fed hydrogen fuel cell analysis energy efficiency operation vehicle made project framed context seeks environmentally friendly alternative current motorcycles order reduce polluting emissions precisely greenhouse gases encouraged kyoto protocol simulation environment tasks performed application numerical model help conceptual design unit sizing real life service battery fuel cell hydrogen hybrid vehicle permits predict vehicle range hydrogen energy consumption results simulations driving cycles real routes test presented aspects emission saving hydrogen consumptions many considered
development science technology demand high quality power supply electrical equipment increasing application analog circuit control research application development power many years already still many shortcomings fpga highly integrated economical high speed low power consumption easy develop maintain significant advantage upgrades like faster integrated versatile advantages stand mcu dsp integrated circuits etc become research application field power electronics control hot spots briefly introduces basic theory digital systems analyze structure model digital systems overview design method digital control system completion selected device selection related development environment tools paper proposes digital power control scheme special surface treatment completion controller hardware software design implementation
background safety biologics important treating patients psoriasis objective sought determine safety ixekizumab psoriasis methods integrated safety data presented week induction period week maintenance period ixekizumab treated patients clinical trials exposure adjusted incidence rates irs per patient years reported results overall patients received ixekizumab total exposure patient years induction period irs patients experiencing treatment emergent adverse event among ixekizumab etanercept treated patients respectively serious aes groups maintenance ixekizumab irs treatment emergent aes serious aes respectively among ixekizumab treated patients trials candida infections irs treatment emergent aes special interest including serious infections malignancies major adverse cardiovascular events comparable ixekizumab etanercept induction period limitations additional long term data required conclusion ixekizumab acceptable safety profile unexpected safety findings ixekizumab maintenance psoriasis
one developed intelligent operating systems mobile devices android taken part cell phone market rapid increase number mobile applications make relevant people daily lives ever due android security mechanism validation lack publishing android apps android malware detection still remains critical issue solve problem paper found statistical information android components mainly activity manifest file ignored based traditional method android permission detection paper new feature vector extracted androidmanifest file combines permission information component information android application combine naive bias classification algorithm propose malicious application detection method based androidmanifest file information experimental results show new method performance better traditional permission detection
aim unit recently shown sacral nerve stimulation sns significantly positive short term effect selected patients diarrhoea predominant mixed irritable bowel syndrome ibs aim present prospective study evaluate medium term efficacy sns ibs establish whether sns could future role treatment ibs method patients ibs previously implanted permanent neurostimulator part randomized controlled crossover study assessed medium term follow primary end point change ibs specific symptom score gastrointestinal symptom rating scale irritable bowel syndrome version questionnaire baseline year follow secondary end point change ibs specific quality life score irritable bowel syndrome impact scale questionnaire baseline year follow results patients eligible year follow median ibs specific symptom score significantly lower year follow range baseline effect observed symptom clusters within score also median ibs specific quality life score significantly improved year follow compared baseline effect observed domains score per protocol patients judged therapeutic successes seventy per cent patients reduction daily ibs symptoms conclusion medium term follow sns continues effective treatment highly selected patients diarrhoea predominant mixed ibs
objectivessacral neuromodulation snm guideline recommended third line treatment option managing overactive bladder current snm devices rechargeable require neurostimulator replacement every years study objective assess potential cost effects payers adopting rechargeable snm neurostimulator device methodswe constructed cost consequence model estimate costs long term snm treatment rechargeable versus non rechargeable device costs considered payer perspective reimbursement levels adverse events therapy discontinuation programming rates based latest published data neurostimulator longevity assumed years non rechargeable rechargeable devices respectively year horizon modeled costs discounted per year total budget impact united states healthcare system estimated based computed per patient cost findings resultsover year horizon per patient cost treatment non rechargeable device versus rechargeable device resulting estimated payer cost savings cost savings found robust across wide range scenarios longer analysis horizon younger patient age longer rechargeable neurostimulator lifetime associated increased cost savings year horizon adoption rechargeable device strategy projected save united states healthcare system billion conclusionsat current reimbursement rates analysis suggests rechargeable neurostimulator snm technology managing overactive bladder syndrome may deliver significant cost savings payers course treatment neurourol urodynam wiley periodicals inc
rate based steady state model absorption amp blended solution presented taking account column hydraulics mass transfer resistances chemical reactions simulation results compared experimental results absorption amp blended solution packed absorption column low high partial pressure conditions model predicts concentration amine concentration chemical enhancement factor liquid temperature profiles along column model good agreement predict concentration profiles along column low partial pressure however found model needs corrected introducing correction factor overall volumetric mass transfer coefficient simulation concentration profiles along column high partial pressure conditions range kpa elsevier rights reserved
many phonetic phenomena occur connected speech classified phonetic periphery anything happen well known convenient way fix phonetic phenomenon using certain symbols transcription current paper aims showing model predicting allophones coordinating number factors determine choice particular allophone visualizing result changing certain letters corresponding ipa symbols free pascal compiler geany editor used programming purposes model created american english tested tap glottal burst latter one three glottalization patterns difference combination factors purely linguistic analysis computer programming explained demonstrate framework integrating separate blocks dealing one phenomenon block tapping almost finalized part block glottalization particularly patterns glottal burst
microgrid low voltage electrical network distributed generations energy storage devices controllable loads paper utilizes artificial neural network ann predict optimum voltages order extract maximum power increment efficiency photovoltaic system regard optimum voltages achieved genetic algorithm optimum values used ann method results ann compared methods verified proposed method high accuracy track maximum power point mpp different insolation temperature circumstances also meet load demand less fluctuation around mpp also increase convergence speed achieve mpp well evaluation fuzzy logic controller flc comparison controller pitch angle wind turbine carried order control output power wind turbine implementing wind speed active power inputs flc faster responses smoother power curves less oscillation aforementioned methods lead improve dynamic responses models developed applied matlab simulink program
background food allergen labeling important tool reduce risk exposure prevent anaphylaxis individuals food allergies health canada released canadian food allergen labeling regulation subsequent update suggesting research needed guide iterations regulation improve food allergen labeling reduce risk exposure objective primary objective study examine consumer preferences food labeling allergy avoidance anaphylaxis prevention secondary objective identify whether different subgroups within consumer population emerged methods discrete choice experiment using fractional factorial design divided ten different versions choice sets per version developed examine consumer preferences different attributes food labeling results three distinct subgroups canadian consumers different allergen considerations food allergen labeling needs identified overall preferences standardized precautionary safety symbols little increased cost emerged conclusion three distinct groups different preferences identified general results revealed current canadian food allergen labeling regulation improved enforcing use standardized precautionary safety symbols educating public use symbols
recent years china gradually consolidating establishment low carbon communities lcc minimize emission greenhouse gasses guangdong province one low carbon pilot provinces also paid great attention building lcc however currently guangdong province even china whole official evaluation system place employed evaluate degree low carbon urban lcc paper aimed establish system evaluating urban lcc guangdong province based actual situations system divided evaluation six categories applied smart criteria select suitable indices set reference values two zones pearl river delta zone prd non prd zone monte carlo ahp combined calculation index weights thus ensuring weight judgment matrixes could pass consistency check addition paper also laid detailed evaluation regulations improve operability system guarantee wide application better generalization finally one typical urban community selected test operability system one time oat method used analyze sensitivity index explore degree influence indices evaluation results results showed three indicators corresponding green building percentage new energy vehicles percentage low carbon public transportation highest sensitivity field test evaluation evaluation system found strong operability high accessibility indicator data system used tool provincial people government guangdong evaluate construction progress degree low carbon lcc also provide reference point experience chinese government draw upon establishing evaluation system lcc national level elsevier ltd rights reserved
background administrative databases increasingly used measure drug exposure perinatal pharmacoepidemiology aimed estimate concordance records prescriptions filled pharmacies self reported drug use pregnancy methods data self reported medication use collected trimester pregnancy among sub sample organization teratology information specialists antidepressants pregnancy cohort women eligible quebec resident provided pharmacist contact information maternal self reports compared prescriptions filled pharmacies transferred pharmaceutical services files quebec provincial health plan database regie asssurance maladie quebec positive negative predictive values ppv npv medications taken chronically antidepressants thyroid hormones acutely antibiotics needed antiemetics asthma medications calculated results among participants mean age years took least one antidepressant pregnancy according self reports according pharmacy records commonly used drugs antiemetics self reported pharmacy record antibiotics asthma medications thyroid hormones ppvs npvs chronic medication antidepressants ppv confidence interval npv thyroid hormones ppv npv acute medication antibiotics ppv npv needed medications antiemetics ppv npv asthma ppv npv conclusion high ppv npv validate use filled prescription data large databases measure medication exposure wiley periodicals inc
estimation method combustion chamber pressure internal combustion engine based processing vibration acceleration signal cylinder head constant speed load conditions presented paper model created based comparison vibration pressure signals around peaks highest vibration preprocessing filtering signal using similar frequency bands sources polynomial regression used selected data points generate resulting model relating pressure vibration average rotational speed per cycle calculated based vibration peaks model tested measurements two spark ignited engine test benches single cylinder engine four cylinder engine resulting model low computational cost provide accurate estimation general shape magnitude pressure trace reflect strongly cycle cycle variations testing normalized root mean square error nrmse best value single cylinder engine scores points vibration peak four cylinder engine values respectively
background cigarette smoking one major preventable causes death diseases qatar study objective test effect structured smoking cessation program delivered trained pharmacists smoking cessation rates qatar methods prospective randomized controlled trial conducted eight ambulatory pharmacies qatar eligible participants smokers years older smoked one cigarettes daily days motivated quit able communicate arabic english attend program sessions intervention group participants met pharmacists four times week intervals participants control group received unstructured brief smoking cessation counseling primary study outcome self reported continuous abstinence months analysis made utilizing data responded also using intent treat principle multinomial logistic regression model fitted assess predictors smoking months analysis conducted using ibm spss version stata version results total smokers randomized two groups intervention control smoking cessation rates higher intervention group months however difference statistically significant similar results observed smaller differences intent treat analysis nevertheless daily number cigarettes smoked relapsed significantly lower cigarettes months respectively intervention group compared control group respectively months difference cigarettes favor intervention group statistically significant years smoking daily number cigarettes predictors smoking opposed quitting months respectively conclusions statistically significant difference smoking cessation rate months groups however smoking cessation program led higher albeit non significant smoking cessation rates compared usual care research conducted identify factors might improve abstinence
background antiretroviral drug discovery formulation design facilitate viral clearance infectious reservoirs although progress realized selected hydrophobic integrase nonnucleoside reverse transcriptase inhibitors limited success seen date hydrophilic nucleosides overcome limitations hydrophobic long acting drug nanoparticles created commonly used nucleoside reverse transcriptase inhibitor lamivudine dideoxy thiacytidine methods step synthesis created slow release long acting hydrophobic conjugation fatty acid created myristoylated prodrug encased folate decorated poloxamer vitro antiretroviral efficacy human monocyte derived macrophages pharmacokinetic profiles mice evaluated decorated nanoformulated drug results stable drug formulation produced poloxamer encasement improved monocyte macrophage uptake antiretroviral activities drug pharmacokinetic profiles native drug formulations conclusions sustained release long acting antiretroviral therapy new therapeutic frontier hiv aids depot formation monocyte derived macrophages facilitated stable subcellular internalization slow drug release
study presents input powered high efficiency interface circuit energy harvesting systems introduces zero standby power design reduce power consumption significantly removing external power supply interface circuit composed two stages first stage voltage doubler uses positive feedback control loop improve considerably conversion speed efficiency boost output voltage second stage active diode adopts common grid operational amplifier amp remove influence offset voltage traditional comparator eliminates leakage current broadens bandwidth low power consumption system supplies harvested energy enables enter zero standby mode near zero crossing points input current thereafter high system efficiency stability achieved saves power consumption validity feasibility design verified simulation results based cmos process minimum input voltage maximum voltage efficiency output current maximum power efficiency output current maximum output power power loss entire interface circuit among amp consumes
energy consumption cellular networks become increasingly important cellular network operators due significant economic ecological influence networks future development alternative energy technologies resulted consideration solar powered base station long term solution mobile cellular network industry reduce operational expenditures footprints cellular networks study addresses deployment operational issues solar powered universal mobile telecommunications system umts third generation mobile cellular system node currently deployed umts node umts node addition study employs hybrid optimization model electric renewable software simulator developed american national renewable energy laboratory four key aspects discussed study optimal solar system architecture energy production cash flow solar powered umts node project economic feasibility solar powered system compared traditional sources simulation results show proposed solution ensures energy autonomy long term energy balance umts node cost effectiveness
detection micro cracks degradation strength materials early stage fracture increasing importance power plants aviation industry methodology detecting micro cracks degradation material using quasi matrix pencil method presented paper damage represented small local elastic modulus reduction response axisymmetric longitudinal guided waves presence modulus reduction studied using finite element method fem axisymmetric damage considered using method calculate dispersion relation excited wave mode small modulus reduction detected using velocity excited guided wave time point calculated dispersion curve changing damage located method used find micro cracks material degradation early stage fracture
professional career builders building supervisors activities accepted especial liability legislator point view every especial liability technical bylaws building control engineering system national building regulations provided ratified necessary sake security protection buildings structures essential basic civil rights analysis relevant laws regulations realize builders supervisors responsibility assumed building fault based liability legislator liability without fault exception fault principle injured party claim compensation loss need prove fault builders supervisors must take utmost caution regard plan complaints aside client third parties buyers passengers entrants construction site owner adjacent sue mentioned persons relatively liable damages life property losses injured persons
myelofibrosis rare haematopoietic disorder commonly diagnosed decade less diagnosed age years retrospective study included patients given diagnosis world health organization defined primary secondary aged years forty three patients median age years included median follow months twenty two harboured jak mutation calr mpl mutations triple negative time diagnosis significant differences existed haematological clinical phenotypes jak calr patients frequency splenomegaly greater jak mutated group compared calr mutated patients whole cohort year probability developing anaemia thrombocytopenia marked leucocytosis respectively finally cumulative incidence thrombotic events progression acute myeloid leukaemia patient year respectively death reported follow findings suggest younger patients may indolent course compared older patients
medical education relies heavily assessment formats require raters assess competence skills learners unfortunately often inconsistencies variability scores raters assign ensure scores assessment tools validity important understand underlying cognitive processes raters use judging abilities learners goal paper therefore contribute better understanding cognitive processes used raters representative findings social judgment decision making cognitive psychology educational measurement literature used enlighten underpinnings rater based assessments particular interest impact judgments referred first impressions thin slices rater based assessments judgments people made quickly based little information narrative review provide synthesis research three literatures social judgment decision making educational psychology cognitive psychology focus underlying cognitive processes accuracy impact first impressions rater based assessments application findings types rater based assessments used medical education reviewed gaps understanding identified suggested directions future research studies discussed
utilizing contraception critical preventing unintended pregnancies among obese women however clinicians obese patients may unclear contraceptive methods optimal review discusses literature weight gain associated contraceptive use contraceptive efficacy among obese women special considerations contraceptive method selection women bariatric surgery review also covers new findings oral emergency contraception obesity
managing aging digital control systems ensures nuclear power plant systems adequate safety margins life cycles software core component execution control logic differs digital analog control systems hardware aging management digital control system similar analog system matured decades study however software aging management still exploratory stage software aging evaluation critical given higher reliability safety requirements nuclear power plants ensure effective inputs reliability assessment paper provides required software aging information life cycle moreover software aging management scheme safety digital control system proposed basis collected aging information
patients superior canal dehiscence scd suffer events dizziness vertigo response sound also known tullio phenomenon present work seeks explain fluid dynamical mechanisms behind accordance called third window theory developed computational model vestibular signal pathway stapes scd based first principles accounts fluid structure interactions arising endolymph perilymph membranous labyrinth simulation results reveal wave propagation phenomenon membranous canal leading two flow phenomena within endolymph close interaction first periodic deformation membranous labyrinth causes oscillating endolymph flow forces cupula oscillate phase sound stimulus second primary oscillations endolymph induce steady flow component phenomenon known steady streaming find steady flow endolymph typically ampullofugal direction flow leads quasi steady deflection cupula increases driving forces steady streaming balanced elastic reaction forces cupula cupula attains constant deflection amplitude lasts long sound stimulus response types observed literature sensitivity study obtain analytical fit well matches simulation results relevant parameter range finally correlate corresponding eye response vestibulo ocular reflex fluid dynamics simplified model lumped system constants results reveal sweet spot within audible sound spectrum find underlying mechanisms lead originate primarily reynolds stresses fluid weaker lower sound frequencies
starting mini micro satellites around become one research focuses space industry different mini satellites developed early ages modern mini micro satellites widely incorporate micro electronics micro mechanisms emphasizing multi functionality system integration result relatively high power volume ratio also reduce fuel consumption application micro electrical propulsion systems mini micro satellites increasing pushes requirement electrical power even higher hard surface mounted solar cells stationary solar arrays widely used micro satellites early ages satisfy elevating power requirements modern mini micro satellites response requirements solar array drive assemblies sada used standard equipments large spacecrafts gradually incorporated mini micro satellites rotate solar arrays maximum sunlight acquisition tremendously reduce size mass solar arrays lately new micro sada integrated mechanisms electronics developed beijing institute control engineering sada features mechanisms electronics integrated one capsule instead separate mechanisms electronic boxes large spacecrafts high torque weight ratio stepper motor high precision mini transmission long life high power weight ratio multi channel slip ring high reliability measures severe mechanical electrical thermal conditions sada gone functional test mechanical tests vibration acceleration shock etc thermal vacuum cycling test electromagnetic compatibility test demonstrated excellent functionality design well development test processes summarized paper
background moseley published randomized controlled trial rct showed difference knee arthroscopy placebo patients osteoarthritis wanted assess impact trial clinical practice united states purpose hypothesis evaluate changes knee arthroscopy practice publication article moseley assess effect landmark rct behavior practicing orthopaedic surgeons hypothesized publication moseley trial overall frequency knee arthroscopy would decrease mean age patients undergoing knee arthroscopy would decrease proportion arthroscopies diagnosis would decrease study design descriptive epidemiology study methods state ambulatory surgery database used analyze cases classified meniscus tear meniscus tear changes age surgery rates case classification evaluated moseley trial using student tests analysis variance results publication trial number knee arthroscopies per year increased mean patient age increased years meniscus tears increased representing approximately additional cases per year decreased representing approximately fewer cases per year meniscus tear increased representing approximately additional cases per year conclusion overall age rates knee arthroscopy increased contrary hypothesis identified decrease rates knee arthroscopy publication moseley trial demonstrating well publicized rcts influence patterns clinical practice
aim current study identify predictors recurrent headache back pain young adults aged years data assessed childhood adolescence years final survey interest whether psychological characteristics contribute risk pain prevalence adult age controlling already empirically supported risk factors parental pain pediatric pain sex study part five wave epidemiological investigation families children aged years addressed first multiple hierarchical regression analysis abovementioned three variables block variables entered first followed five psychological trait variables block variables internalizing anxiety sensitivity somatosensory amplification catastrophizing dysfunctional stress coping find extent model improvement multivariable hierarchical regression analysis confirmed hypothesis block variables significantly enhance risk future pain young adult age none psychological variables thus hypothesis significant surplus predictive effect confirmed amount total explained variance differed strongly headache back pain particular valid prediction back pain possible analyzed separately simple regression analysis psychological variables turned significant predictors however low effect size inclusion block variables model clearly reduced impact psychological variables risk profile discussed context different trajectories headache back pain childhood adult age proposed various studies propose biopsychological characteristic denoted emotional negativity especially regarding self reference might common factor behind selected variables risk research recurrent pain field much multidisciplinary research needed progress expected
paper studies information content chromosomes species first phase scheme inspired dynamical system state space representation developed chromosome state space dynamical evolution shed two dimensional chart plots analyzed characterized perspective fractal dimension information integrated two measures species complexity addressing average variability results close accordance phylogenetics pointing quantitative aspects species genomic complexity elsevier rights reserved
background development performance indicators enable benchmarking organizations important mechanism accountability organizational learning performance improvement province quebec canada rehabilitation organizations developed common set performance indicators interorganizational collaboration purpose aims study describe rehabilitation organizations use common set performance indicators identify factors influencing use approach qualitative survey performed individual semistructured interviews conducted executives working rehabilitation organizations using common set performance indicators thematic analysis factors use performed according consolidated framework implementation research use performance indicators categorized purposeful political passive findings results showed organizations used common set performance indicators four factors identified important rehabilitation organizations explain interest comparative performance indicators need develop performance indicators compatibility performance information organizational needs complexity simplicity performance information support offered common association sixty three percent rehabilitation organizations made purposeful political use performance indicators three main factors contributed typify organizations others perceived quality performance indicators leadership decision makers resources available practice implications results showed use performance indicators support initiation projects improving quality care key recommendations proposed decision makers may enhance performance indicators use
objective aim study identify socio demographic home environmental predictors shorter sleep early childhood examine whether effects mediated timing bedtime wake time methods participants gemini british birth cohort twins included children one randomly selected twin pair parents reported night time sleep duration average age months range months using modified version brief infant sleep questionnaire multiple logistic regression models used identify predictors shorter sleep study results using cut older child watching evening independently associated shorter sleep mediation analyses showed associations education ethnicity evening viewing sleep driven predominantly later bedtimes sex differences driven predominantly earlier wake times boys conclusion sample multiple environmental factors associated shorter sleep young children several operating predominantly later bedtime emphasis importance early consistent bedtime could help promote healthy sleep reduce inequalities child health authors published elsevier
house solution verification dose delivered moving phantom required clinical implementation lung stereotactic ablative body radiation therapy developed superior inferior movement required simulate tumour motion normal breathing cycle achieved via novel use arduino uno low cost open source microcontroller board connected high torque servo motor slow imaging used acquire image set cone beam cbct verified efficacy contoured margins treatment moving phantom treatment fields delivered section cirs anthropomorphic phantom dose verification dynamic phantom gafchromic ebt film using gamma analysis acceptance criteria registered absolute dose pass rate imrt vmat respectively verified ptv received prescribed dose per fraction using dynamic phantom major discrepancy planned measured results due interplay multileaf collimator sequences target motion observed study confirmed use house solution using open source hardware software existing quality assurance equipment appropriate validating new treatment technique
although organizations use variety interventions improve group functioning getting people work effectively remains challenging presence dog shown positive effects mood dyadic interaction expected presence companion dog would also positive effects people work groups one reason companion dog likely elevate positive emotions often promote prosocial behavior study study participants randomly assigned either dogpresent dog absent four person group three friendly companion dogs randomly assigned dog present groups one dog time used given experimental session study groups worked interactive problem solving task participants dog present group displayed verbal cohesion physical intimacy cooperation study identical except participants worked decision making task requiring less interaction participants dog present condition displayed verbal cohesion physical intimacy gave higher ratings trustworthiness fellow group members study examined behavioral indicators positive emotions dog present dog absent groups naive observers rated silent second video clips interaction groups either dog present visible present behavior dog present groups rated cooperative comfortable friendly active enthusiastic attentive discuss areas future research implications findings work educational settings
hard nonlinearity hysteresis effect main obstacle smart material based actuators makes optimal usage impossible thus essential develop comprehensive strategy modeling control order mitigate hysteresis nonlinearity paper investigates viability differential equations based models towards hysteresis characterization control fusion strategy order solve tracking problem piezoelectric based actuators analytical simulation results suggest category model simple use clear physical meanings importantly established bouc wen model ability synthesized directly control design finally control strategy devised based model experimentally verified discrete time domain
growing interest using intranasal oxytocin treat social dysfunction schizophrenia bipolar disorders psychotic disorders treatment results mixed emerging evidence suggests system dysfunction may also play role etiology metabolic syndrome mets appears one third individuals psychotic disorders associated increased mortality examine evidence potential role system shared risk mets psychotic disorders prospects ameliorating mets using several studies demonstrate overlapping neurobiological profiles metabolic risk factors psychiatric symptoms show system dysfunction may one common mechanism underlying mets psychotic disorders given critical need better understand metabolic dysregulation disorders future trials assessing behavioural cognitive outcomes additionally include metabolic risk factor parameters elsevier inc rights reserved
present experiments explored relationship individual differences working memory capacity susceptibility false recognitions accompanying subjective experiences deese roediger mcdermott drm associative lists used elicit false memories remember know judgments used measure recollective experiences accompanying recognition decisions found capacity related false recognitions nonpresented critical lures proportion remember responses given critical lures higher capacity associated lower false recognition rates lower proportions remember responses importantly differences found participants forewarned nature drm task prior encoding exp forewarning absent capacity related false recognitions proportion remember responses given critical lures exp results support controlled attention view suggest subjective experiences falsely recognized lures fluctuate function capacity
paper applied balanced truncation based model order reduction wind farms starting simplified linearized model variable speed wind turbine generator operating maximum power tracking state space representation wind farm considered wind velocities input farm power output hankel singular values computed indicate likely order farm may reduced found reduced model matches well initial cluster centers distribution inertia wtgs present original wind farm reduced order model retains dynamic relationship variation wind speed consequent power output variations accurately wide range frequencies elsevier ltd rights reserved
psychosocial environment especially various psychosocial risks childhood shown predict later negative health behavior health problems study examined whether various psychosocial factor domains childhood adolescence socioeconomic status theemotional family environment parental nurturance life satisfaction parental lifestyle life events child self regulatory behavior child social adaptation associated body mass index bmi trajectories individually domain cumulative score across domains participants nationally representative sample men women fromthe young finns study aged years study entry bmi wasmeasured six study phases parents reported factors related psychosocial environment participants responded questions adulthood socioeconomic status accumulation psychosocial factors childhood main exposure variable findings fromrepeated measuresmultilevelmodeling showed parental lifestyle life events positive cumulative psychosocial factors score associated slower increase bmi follow regression coefficient range conclusion psychosocial environment childhood adolescence particularly parental lifestyle lack stressful life events associated lower increase bmi elsevier inc rights reserved
interesting imagine many diverse places settings nurses serve individuals families communities unique knowledge base nurses working rural areas many challenges opportunities since work isolated areas wide open air limited access healthcare
background prevalence dietary supplements increased japan consequence adverse events associated dietary supplement use become prominent severe adverse events must reported japanese government via public health centers however number cases reported japanese government limited clarify discrepancy conducted internet questionnaire surveyed consumers physicians pharmacists acted patients developed adverse events due dietary supplement use methods study completed consumers physicians pharmacist via internet surveillance november results although consumers developed adverse events including diarrhea constipation stomachache headache nausea vomiting report adverse events public health centers however consumers went hospitals adverse events also surveyed physicians pharmacists acted patients developed adverse events due dietary supplement use physicians pharmacists report cases public health centers unable definitively prove cause effect relationship adverse events furthermore physicians pharmacists know report adverse events conclusions clarified reasons limited number reports adverse events japanese government survey important encourage consumers also physicians pharmacists report adverse events public health centers addition analyzing tool cause effect relationships might helpful physicians pharmacists
autism spectrum disorder asd associated reduced orienting social stimuli eyes results inconsistent known whether atypicalities phasic alerting could play role putative altered social orienting asd show unisensory visual trials children asd slower orient eyes among distractors controls matched age sex nonverbal however another condition brief spatially nonpredictive sound presented visual targets group effect reversed results indicate orienting social versus nonsocial stimuli differently modulated phasic alerting mechanisms young children asd autism res authors autism research published wiley periodicals inc behalf international society autism research
children autism atypical gaze behavior unknown whether gaze differs distinct types reciprocal interactions typically developing children children autism years made similar amounts eye contact examiner conversation surprisingly minimal eye contact interactive play groups gaze behavior stable across weeks children autism lastly gaze behavior conversation play associated autism social affect severity scores ados css social responsiveness scale srs together findings suggests eye contact typical atypical development influenced subtle changes context implications optimizing assessments social communication skills
describe patient hereditary angioedema type patient experienced recurrent abdominal pain around time menstrual period years laboratory examination showed reduced functional antigenic levels inhibitor inh establish diagnosis carried dna analysis patient inh gene determined patient heterozygous single base pair transposition nucleotide exon reported literature patient family history hereditary diseases considered novo mutation
purpose main purpose study provide effective sizing method optimal peak shaving strategy energy storage system reduce electrical peak demand customers cost savings analytical tool developed provide quick rule thumb customers choose appropriate size energy storage various tariff schemes design methodology approach novel sizing method proposed obtain optimum size energy storage commercial industrial customers based historical load profile algorithm developed determine threshold level peak shaving one buildings universiti tunku abdul rahman utar malaysia chosen study three phase energy storage system rated kva developed connected low voltage electrical network building adaptive control algorithm developed implemented optimize peak shaving findings sizing analysis shows customer tariff rate yields highest saving followed experimental results presented indicate proposed adaptive control algorithm effectively optimized peak demand shaved research limitations implications study demonstrates potential energy storage reducing peak demand cost electricity one main challenges real time peak shaving determine appropriate threshold level energy stored energy storage system sufficient peak shaving process originality value originality paper optimal sizing method energy storage system based historical load profile adaptive control algorithm optimize peak demand deduction
modern problems optimization estimation signal image processing pattern recognition etc deal huge dimensional data necessitates elaboration efficient methods processing data idea building low dimensional approximations huge data arrays heart modern data analysis one appealing methods compact data representation statistical method referred principal component analysis however sensitive uncertainties available data presence outliers paper robust versions principle component analysis approach proposed along numerical methods implementation
aim study compare bone variables active overweight obese men sedentary overweight obese men thirty seven active overweight obese men sedentary overweight obese men participated study weight height measured body mass index calculated body composition bone variables bone mineral content bmc bone mineral density bmd geometric indices hip bone strength trabecular bone score measured dxa physical activity level daily calcium intake daily protein intake sleep duration measured validated questionnaires maximum oxygen consumption max determined direct measurement exercising medical treadmill one repetition maximum half squat lower limbs measured using validated protocol body weight body mass index higher sedentary overweight obese men active overweight obese men whole population max liter per minute lean mass one repetition maximum half squat positively correlated bmc bmd geometric indices hip bone strength cross sectional area section modulus femoral neck adjusting body weight using way analysis covariance active overweight obese men displayed higher whole body bmc lumbar spine bmd total hip bmd bmd cross sectional area values sedentary overweight obese men conclusion current study suggests physical activity level positively affects bone variables overweight obese men optimizing lean mass muscular strength lower limbs help prevent osteoporosis overweight obese men
rapid development mobile data acquisition technology volume available spatial data growing increasingly fast pace real time processing big spatial data become research frontier field geographic information systems gis cope highly dynamic data aim reduce time complexity data updating modifying traditional spatial index however existing algorithms data structures based single work nodes incapable handling required high numbers update rates moving objects paper present distributed spatial index based apache storm open source distributed real time computation system using approach compare range nearest neighbor knn query efficiency four spatial indexes single dataset introduce method performing spatial joins two moving datasets particular build secondary distributed index spatial join queries based grid partition index finally series experiments presented explore factors affect performance distributed index demonstrate feasibility proposed distributed index based storm real world application approach integrated information system provides real time traffic decision support
introduction aim study compare effect ramipril canrenone versus ramipril hydrochlorothiazide hctz combination atrial fibrillation recurrence type diabetic hypertensives without cardiac autonomic neuropathy material methods total hypertensive type diabetic patients sinus rhythm least two episodes previous months randomized ramipril plus canrenone titrated ramipril plus hctz titrated amlodipine titrated year clinic blood pressure ecg evaluated monthly patients asked report episode symptomatic perform ecg early possible serum procollagen type carboxy terminal peptide pip carboxy terminal telopeptide collagen type citp evaluated treatment period results blood pressure similarly significantly reduced treatments total patients amlodipine recurrence patients ramipril hctz amlodipine patients ramipril canrenone amlodipine ramipril hctz similar trend found diabetic patients combinations reduced pip increased citp effects ramipril canrenone significantly marked conclusions findings suggest type diabetic hypertensives ramipril canrenone treatment effective ramipril hctz reducing recurrence could related greater improvement cardiac fibrosis
associations found among sexting attachment insecurity emotional dysregulation sexual risky sexual behavior young adults sample young adult women romantic relationships study aimed examine whether emotional regulation might constitute indirect pathway linking attachment sexting potential implications engaging condomless sex findings revealed young adult women romantic relationships attachment anxiety associated sexting difficulty controlling impulses moments emotional distress also sexting directly predicted condomless sex attachment avoidance anxiety associated sexting bivariate correlations findings highlight role digital technology understanding people negotiation needs attachment emotional regulation might lead risky sexual behavior interventions targeting interplay attachment emotional regulation technology use may positively impact relational behavioral health outcomes elsevier ltd rights reserved
china rapid urbanization generated substantial attention throughout world various studies assess china urbanization process without consistent conclusions paper attempts evaluate china urbanization level based global urban development experience urbanization theories addition adopts quadrant plots method assess china regional urbanization level results study show china urbanization rate proceeding normal level consistent northam curve growth theory lewis migration theory chenery theory normal growth also china economic development stage however certain problems challenges remain examined low level coordination china urbanization nonagricultural employment narrow difference urbanization rate industrialization level general eastern provinces show high coordination urbanization economic development whereas provinces low coordination low urbanization rate economic development levels located central western china results advance previous literature also deserve particular attention chinese policymakers local governments pay close attention urbanization quality urban planning support systems upgrading industry structure focusing much urbanization quantity american society civil engineers
background purpose increasing evidence suggests presence demyelination normal appearing white matter nawm patients neuromyelitis optica spectrum disorder nmosd objective determine presence subclinical demyelination nawm patients nmosd using myelin water imaging mwi methods whole brain regions interest rois analyses including centrum semiovale corona radiata genu splenium corpus callosum optic radiation conducted nawm nmosd patients healthy controls hcs using two mwi modalities conventional mwi direct visualization short transverse relaxation time component vista mwi results conventional myelin water fractions mwfs global nawm three rois centrum semiovale corona radiata genu corpus callosum slightly lower nmosd patients hcs although statistically significant hand vista mwf values global nawm rois except genu corpus callosum significantly lower nmosd patients relative hcs particular mwf optic radiation significantly reduced nmosd patients relative hcs mwi methods even patients brain involvement additionally patients optic neuritis showed lower mwf patients without optic neuritis negative correlation identified mwf optic radiation visual functional system score conclusions study identified presence widespread demyelination nawm nmosd patients highlighted optic radiation site marked demyelination
membrane structures lightweight highly optimized structures due constant stress state strength materials used optimally order prevent occurrence large deformations even small external loads membrane structures designed double curved surfaces stabilized applying prestress minimal surfaces zero mean curvature basic advantage stress points directions equal extreme stresses anywhere surface also minimal area given contour weight amount material reduced minimum make suitable application architecture practical realization involve process cutting pattern generation divide surfaces parts developable surfaces patterns assembled prestressed provide three dimensional surface ideally cutting lines follow geodesics lines use geodesics shortest path two points surface article give method finding shortest paths polygonal representations surfaces follows continual dijkstra paradigm conditions give improved accuracy computer despite restriction available memory execution time
background modern gynecology intrauterine device iud levonorgestrel often used method contraception levonorgestrel releasing intrauterine system small shaped slovenia gynecologist may insert cases present clinical cases despite strong evidence perforation occurred insertion iud found outside uterus iud threads visible iud located uterine cavity ray abdomen must performed iud found abdominal cavity outside uterus removal laparoscopy carried conclusion given large number inserted iuds complications associated levonorgestrel releasing intrauterine system quite rare therefore remains one widely used contraceptive methods reprod med
recent efforts revealed numerous natural antisense incrnas play crucial role regulation cancer biology based previous study identified incrna foxc antisense transcript foxc positively regulated doxorubicin resistant osteosarcoma cell lines tissues correlate poor prognosis promote doxorubicin resistance osteosarcoma cells vitro vivo addition foxc foxc mainly located cytoplasm form rna rna double stranded structure overlapping region necessary foxc regulate expression foxc transcription post transcription levels addition transcription factor foxc also contributes doxorubicin resistance inducing expression classical multi drug resistance related abcb gene similar foxc thus concluded incrna foxc may promote doxorubicin resistance increasing expression transcription factor foxc facilitating abcb expression findings demonstrate potential underlying mechanism foxc regulation doxorubicin resistance possibly provide novel reversing target elsevier rights reserved
study attempted examine validity italian version career factors inventory cfi psychometric tool widely used assessment cognitive personal emotional dimensions career indecision among sample italian students attending high school university recurring exploratory confirmatory factor analyses original four factor structure confirmed returned line literature satisfactory reliability indices moreover cfi subscales showed intercorrelations consistent previous studies albeit lower cases subsequently convergent validity four cfi subscales scales via zero order correlation tested confirming previous evidence except need career information conclusion consistent previous studies italian version cfi showed valid reliable instrument evaluation dimensions career indecision
study reports outcomes follow low cost postcard intervention randomized control trial hospital treated self poisoning intervention postcards months plus usual treatment versus usual treatment three binary endpoints months suicidal ideation suicide attempt self cutting significant reduction suicidal ideation rrr nnt suicide attempt rrr nnt non western population however effect self cutting rrr sustained brief contact mail may reduce forms suicidal behavior self poisoning patients post intervention phase
subject study modern sociology increasingly become new social reality associated issue sex gender article presents author materials comparative sociological research main aim study analyze complex process becoming gender education universities petersburg kiev empirical study conducted based content analysis expert interviews questionnaire survey basis results obtained questionnaire survey draw following conclusions teachers reading courses consider meet needs students receive modern education among students attended training courses gender issues number interested students prevailed number disinterested among topics caused students interest attracted themes practical orientation problems work family balance gender roles house work sexuality gender inequality labour market gender education special attention paid process formation development gender studies gender sociology petersburg state university however process gender mainstreaming gender studies sociology gender context sociological education overall positive also contradictory complex dynamics problems associated lack coherent long term state policy field gender education enlightenment insufficiently developed theoretical methodological base state educational standards programs gender studies gender sociology academic disciplines
micrornas mirnas reported critical players osteosarcoma among numerous cancer related mirnas expression level mir potential role investigated showed overexpression mir identified specimens cells compared normal bone tissues high level mir correlated high classification advanced clinical stages patients notably mir highly expressing patients showed notably reduced survival rate vitro experiments showed loss mir inhibited uos cell proliferation cell cycle progression induced apoptosis turn restoration facilitated cell growth suppressed apoptosis experimental nude mice showed mir silencing prohibited vivo growth cells furthermore bioinformatics software predicted box repeat containing protein fbxw direct target mir observed negative regulation mir fbxw expression direct binding verified dual luciferase assays cells forced expression fbxw resulted reduced proliferation cell cycle arrest phase increased apoptosis mir overexpressing cells summary study demonstrates mir probably functions driver tumor progression targeting fbxw highlights potential effects mir prognosis treatment published elsevier
integrated computational materials engineering icme emerging discipline accelerate product development unify design manufacturing paper summarizes icme applications optimizing welding thermal forming processes first application numerical analyses conducted control weld distortion using intermittent welding replace full length double sided fillet welds adapting new low heat input processes hybrid laser arc welding process second application existing software tool validated applied automate thermal plate forming process extensively used shipbuilding industry form curved plates several decades
demonstrate fabrication response smart material combined spiropyran molecules spiropyrans belong class compound constitute molecular switch change color response different stimuli heat light mechanical stress molecules incorporated polythiourethane ptu shape memory polymer observations revealed molecular switches alter physical properties ptu general however spiropyran molecules smart polymer show changes individually exposed heat microscopic mechanisms switching process response external stimuli discussed detail
waxy starches consist almost exclusively amylopectin contain amylose molecules despite extensive knowledge certain applications waxy maize starch former times production use high amylopectin starches increasing review deals physical processing starches via gelatinization gelation extrusion annealing heat moisture treatment chemical biochemical modification acetylation debranching amylopectin hydrolysis great attention paid digestibility products formation nanoparticles usual new food non food uses rice maize wheat barley potato waxy starches referred elsevier ltd rights reserved
problem stereoscopic image quality assessment finds applications visual content delivery dtv investigated work specifically propose new paraboost parallel boosting stereoscopic image quality assessment pbsiqa system system consists two stages first stage various distortions classified types individual quality scorers targeting specific distortion type developed scorers offer complementary performance face database consisting heterogeneous distortion types second stage scores multiple quality scorers fused achieve best overall performance fuser designed based parallel boosting idea borrowed machine learning extensive experimental results conducted compare performance proposed pbsiqa system existing stereo image quality assessment siqa metrics developed quality metric serve objective function optimize performance content delivery system elsevier inc rights reserved
paper seeks investigate impact foreign direct investments fdis industrial pollution bod emissions large sample highly heterogeneous countries using panel data manufacturing fdis france germany sweden united kingdom developing empirical model first second order interaction terms investigate existence conditionality controversial fdi induced effects industrial emissions pollution factor endowments pollution halo hypotheses paper three main findings central hypotheses linking pollution fdi found act simultaneously opposing effects fdis associated pollution reduction predominating pollution halo induced effect countries low average capital labour ratio lax environmental regulation fdis found increase pollution prevailing pollution factor endowments induced effects countries average capital endowments lax environmental regulations well capital abundant countries though smaller magnitude countries strict environmental regulations high skilled labour force specific interesting findings discussed regarding different fdi origin countries fdi host country groups
background protein kinase pkc theta serine threonine kinase involved cell activation proliferation type innate lymphoid cells ilcs resemble cells produce cytokines lack antigen specific receptors mechanism pkc theta drives innate immune cells instruct responses patients allergic lung inflammation remains unknown objectives hypothesized pkc theta contributes ilc activation might necessary ilcs instruct response methods prkcq gene expression assessed innate lymphoid cell subsets purified human pbmcs mouse lung ilcs ilc activation eosinophil recruitment related cytokine chemokine production lung histopathology interferon regulatory factor irf mrna expression nuclear factor activated cells nfat protein expression determined adoptive transfer ilcs wild type mice performed wild type pkc theta deficient pkc theta mice results report pkc theta expressed human mouse ilcs mice lacking pkc theta reduced ilc numbers cell numbers activation airway hyperresponsiveness expression transcription factors irf nfat importantly adoptive transfer ilcs restored eosinophil influx production lung tissue well cell activation pharmacologic pkc theta inhibitor compound administered allergen challenge reduced ilc numbers activation well airway inflammation irf nfat expression conclusions therefore findings identify pkc theta critical factor ilc activation contributes cell differentiation associated irf nfat expression allergic lung inflammation
computer generated holography plays main role contents generation holographic displays digital archiving three dimensional objects fully analytic mesh based computer generated holography finds exact complex optical field triangular mesh three dimensional objects given sampling interval hologram plane without approximation enhancing quality reconstruction mesh based processing rather conventional point based one makes compatible computer graphics techniques efficient especially large objects paper present recent progress fully analytic mesh based computer generated holography techniques including dark line artifact removal continuous shading mesh surface implementation angular reflectance distribution object surface application texture map
aims objectivesto identify nurse leaders view experience opportunities offered one largest global nursing organisations sigma theta tau international backgroundworldwide nursing leadership challenged addressing complex issues impacting care delivery international nursing organisations means bring together individuals promote leadership scholarship nursing practice promote patient safety quality care newly established england chapter sigma theta tau international recent addition society terms nurse leadership europe faces challenges establishes identity seeks interpret organisational vision advance world health nursing leadership scholarship moving forward members views sought goals chapter may enacted designin july chapter members time nominated basis achievement nurse leadership invited participate online survey online questionnaire contained series closed open questions resultsmost respondents joined believed vision networking opportunities sigma theta tau international provides three themes extracted data value networking communication leadership development culturally sensitive organisations need shared scholarship nursing practice conclusionfindings indicate growth effective leadership levels nursing could harnessed successful collaboration keen support robust connections practice education promote quality care relevance clinical practicewhilst challenging globalisation presents opportunity nursing society sigma theta tau international work collaboratively address healthcare issues nursing society explores resolves complex issues actively promoting leadership collaborative scholarship reveals potential empower profession share collective solutions towards enhancing clinical practice
triarchic model psychopathy describes complex condition terms distinct phenotypic components boldness meanness disinhibition brief self report scales designed specifically index psychopathy facets thus far demonstrated promising construct validity present study sought develop validate scales assessing facets triarchic model using items well validated existing measure psychopathy psychopathic personality inventory ppi consensus rating approach used identify ppi items relevant triarchic facet convergent discriminant validity resulting ppi based triarchic scales evaluated relation multiple criterion variables psychopathy inventories antisocial personality disorder features personality traits psychosocial functioning offender nonoffender samples ppi based triarchic scales showed good internal consistency related criterion variables ways consistent predictions based triarchic model findings discussed terms implications conceptualization assessment psychopathy
backgroundfranklin delano roosevelt fatal brain hemorrhage april provides excellent platform study potential causes one famous headaches history impressionthe differential diagnosis thunderclap headache including hypertension melanoma discussed roosevelt health problems context serious diseases leaders tangible effect upon historical interpretation discussiona large body evidence presented support probable cover roosevelt health problems perpetrated doctors close confidantes necessity challenging conventional thinking health leaders fundamental importance understanding health issues also emphasized
palatine rugae development mice cell cluster appeared transiently palatine rugae epithelium characteristics cells examined histologically immunohistochemically anti cytokeratin anti protein gene product pgp antibodies using mice embryonic day postnatal day epithelium palatine rugae located anterior portion inter rugae area consisted cell layers palatine rugae papillae epithelium however palatine rugae located posterior portion cell clusters epithelium cells expressed immunopositive reactions anti although react anti anti immunopositive cell cluster palatine rugae epithelium anti pgp immunoreactivity observed papillae moreover basal cells cell cluster showed anti immunoreactivity cell cluster palatine rugae epithelium disappeared gradually anti immunopositive cells also disappeared however anti pgp immunoreactivity papilla maintained disappearance anti immunoactivity palatine rugae epithelium epithelium palate including palatine rugae stratified keratinized findings suggested cell cluster palatine rugae epithelium may considered taste bud like structure according expression pattern anti may play important role nerve innervation papilla palatine rugae epithelium
evolvable hardware ehw hardware dynamically change behavior architecture interacting environment ehw make use evolutionary algorithms eas optimally synthesize electrical circuits paper five different mutation methods implemented conventional genetic algorithm technique automatically realize digital bit full adder main achievement work comparison techniques terms number iterations required converge required logical structure results demonstrate sequential mutation method smm circular gene method cgm reduce convergence time substantial reduction observed methods combined adaptive group mutation agm method full adder implementation elsevier ltd rights reserved
order realize interactive teaching course machine design foundation use campus network computer aided design software construct network teaching platform platform consists three modules interactive teaching module teacher management module system management module advantage platform realize remote assistance function mechanical drawing design according characteristics course improve communication ability teachers students premise ensuring sharing resources
infections caused acinetobacter baumannii increasingly prevalent nosocomial pathogen associated high morbidity mortality conducted study analyze clinical features outcomes factors influencing survival patients bacteremia retrospectively examined medical records patients developing bacteremia hospital stay tertiary care hospital beirut ninety episodes bacteremia documented eighty five patients univariate analysis showed prior exposure high dose steroids diabetes mellitus mechanical ventilation prior use colistin tigecycline presence septic shock critical care unit stay associated poor outcome high dose steroids presence septic shock significant multivariate analysis crude mortality rate deaths attributed bacteremia acquisition patients septicemia despite high index suspicion initiation colistin tigecycline patients grim outcome could averted patients died within days seven patients transient benign bacteremia three treated removal line remaining four receive antibiotics due withdrawal care died within days acquiring bacteremia signs persistent infection follow prolonged hospital stay frequently associated loss functionality steroid antibiotic exposure factors seem impact mortality bacteremia disease high mortality rate limited therapeutic options
cyanobacteria algae complex photosynthetic systems channelize absorbed solar energy forms energy production food metabolites addition promising biocatalysts used field white biotechnology enhancing sustainable production food metabolites green energy sources biodiesel review endeavor made uncover significance various metabolites like phenolics phytoene terpenoids phytols sterols free fatty acids photoprotective compounds maas scytonemin carotenoids polysaccharides halogenated compounds etc phytohormones cyanotoxins biocides algaecides herbicides insecticides etc apart importance metabolites antibiotics immunosuppressant anticancer antiviral anti inflammatory agent also discussed metabolites obtained cyanobacteria algae several biotechnological industrial pharmaceutical cosmetic uses also discussed review along emerging technology harvesting enhancing production compounds like bioethanol biofuel etc commercial level later sections discussed genetically modified organisms metabolite production also briefly discussed concept bioprocessing highlighting functioning companies engaged metabolites production well cost effectiveness challenges addressed companies
intercultural communicative competence training important task english teaching teachers cross cultural communication ability directly influences training students ability intercultural communication based english teachers intercultural communication ability could meet requirement era quality education present situation study influence factors cross cultural communication ability english teachers intercultural communication competence foundation put forward way english teachers intercultural communication ability specific include expanding global cultural knowledge enhance communication ability combination various training modes improve ability cross cultural communication strengthen teaching college english relationship cross cultural communication research promoting comprehensive cultural quality english teachers nonverbal communication consciousness enhance sensitivity cross cultural communication
morning glory spillways type spillways used pass flood upper lower height types spillways used dam reservoir narrow valleys locations slope reservoir walls high morning glory spillways existence whirlpool could reduce flow rate flow rate index spillway function zigzag spillway introduced proper option compensating problem spillways face passing maximum possible flow rate spillways non linear crown definite width compared spillways straight crown similar height flow rate passing spillway direct present study physical model morning glory spillway developed entrance spillway zigzag spillways installed different parts spillway different flow rate flow rate index examined free flow state results offered diagrams analysis experimental data shows fixed submergence depth increase length spillway number zigzag increase flow rate
work innovative shore marine turbine deployed peculiarity anchoring system consisting rope subjected tensile stress central deflector responsible equilibrium horizontal plane floating stabilizer keeping machine vertical position introduction couple rotors instead one important step machine design rotating opposite direction rotors make machine free torsional effects based experience gained design procedure turbine described considering equilibrium conditions key point design equations horizontal vertical plane obtained horizontal plane equilibrium guaranteed central deflector vertical one guaranteed buoyant stabilizer several calculations simulations carried site punta pezzo messina italy energy output payback time evaluated elsevier ltd rights reserved
indoor positioning techniques considered use within team sports players tracked recorded providing coaching assistance global positioning system gps facto standard employed estimate location players unsuitable accurate indoor positioning due roof wall signal obstruction dozen techniques suggested wireless indoor positioning static moving objects improved methods limiting position estimation errors indoor techniques rely radio frequency signal propagation propagation statistics useful determining path loss signal degradation static indoor propagation knowledge critical design wireless indoor positioning systems ultimately accuracy position estimation signal path propagation losses variations produced shadowing multipath fading scattering diffraction objects hinder designer efforts provide reliable accurate positioning system however sporting indoor environments generally open floor area play conducted free objects apart players elite sporting level indoor play areas designed constructed international specifications consequently static wireless signal propagation knowledge obtained one commonly built play areas applicable hundreds venues around world many indoor sporting areas used variety sports example basketball volleyball indoor cricket indoor soccer netball handball player positioning installation could potentially used sports paper reports wireless signal propagation ghz waist mounted beacon indoor sporting venue play area designed international standards basketball court constructed highly polished wood chosen sample play area propagation models discussed comparisons predicted measured results demonstrate validity technique authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
objectives belimumab first biologic drug approved systemic lupus erythematosus sle aimed investigate effects belimumab clinical serologic outcomes sought identify predictors treatment response three swedish real life settings methods fifty eight patients enrolled initiation belimumab followed longitudinally months surveillance outcomes included sle disease activity index sledai visual analogue scales physician global assessment pga fatigue pain general health systemic lupus international collaborating clinics american college rheumatology damage index sdi assessment treatment response included sle responder index sri lymphocyte stimulator blys levels determined using elisa results sledai median baseline score iqr pga corticosteroid use decreased therapy patients reported improvements fatigue pain general health showed decreased probability prolonged time attain sri response current smokers compared nonsmokers contrast baseline blys levels predicted increased probability shorter time attain sri response conclusions disease activity corticosteroid usage decreased patient reported outcomes improved significant organ damage accrued follow smoking organ damage predicted reduced treatment efficacy findings might contribute better selection patients likely benefit belimumab elsevier rights reserved
myelodysplastic syndrome mds characterized ineffective hematopoiesis production aberrant clones high cell apoptosis rate bone marrow macrophages charge phagocytosis innate immune cells specific cells charge immunosurveillance little known cell recruitment activity aspirate frequently contaminated peripheral blood evidences suggest active role immune cells protection mds secondary leukemia cells directly cytotoxic distinct cytokine signature mds producing tnf alpha ccl ccl tnf alpha fasl trail tools promote apoptosis aberrant cells hand also increase mds related cytopenia myelofibrosis together tgf beta produced stromal cells amplifies cytotoxicity also vicious circle tnf alpha production myeloid derived suppressing cells mdsc increased mds ambiguous role protection progression diseases expressed hematopoietic stem cells mds might potential target biotherapy mds also impact immunity favor chronic inflammation emergence autoimmune disorders site hematopoiesis thus contains complex population cells different stages differentiation stem cells early engaged precursors almost mature cells lineage including erythrocytes megakary ocytes myelo monocytic cells monocyte macrophage granulocytes cells cells monocytes cell finalize maturation peripheral tissues lymph nodes migration blood hand cells develop thymus present mature cells like well vascularized tissues precursors strong proliferative capacity usually associated high risk genetic errors cell dysfunction consequent cell death abnormal cells prone destruction spontaneous apoptosis immunosurveillance needs stay highly vigilant high rates proliferation differentiation failures lead high rate cell death massive release debris captured destroyed numerous macrophages reside charge home keeping high capacity phagocytosis required clearing debris
background aim study establish whether possible make correct diagnosis various types eating disorders basis several variables method group females years age took part study women control group women research group used eating disorder inventory edi socio cultural attitudes towards appearance questionnaire sataq questionnaire behavior towards body selection dependent variable predictors disorder made classification tree developed results people suffering eating disorders differ healthy individuals intensity variable pattern constructing emotional relationships basis lack trust certainty interpersonal relations people suffering various types eating disorders differ besides bmi psychological traits fear gaining weight restrictive strive slim well dissatisfaction body differential diagnosis line decision algorithm correctly identified healthy individuals cases bulimia cases binge eating disorder cases anorexia cases conclusions psychological predictors eating disorders may arranged form classification tree possible make accurate differential diagnosis eating disorders basis results measurements six variables
background qualitative study aimed explore mothers gave meaning experiences raising child autism spectrum disorder asd malaysia methods using interpretative phenomenological analysis semistructured interviews conducted malaysian mothers different ethnic backgrounds chinese malays indian results three themes mothers adaptation wellbeing development identified including problem realisation within context learning spell malaysia living autism resilient overcoming climbing mount kinabalu mothers viewed child asd symptoms behaviour problems hyperactivity sleep difficulties taking toll wellbeing however coping strategies including acceptance proactive mindset character growth spirituality parent support networks fostered wellbeing conclusion intrapersonal interpersonal protective processes important findings suggested seligman perma framework may applicable understanding parental wellbeing clinical policy research suggestions discussed
surface processing characterization needed today nearly engineering disciplines especially nanoscale control testing conditions sample preparation device operations require special techniques undergraduate engineering students general however receive limited training nanoscale surface processing analysis cross disciplinary curricula consisting six courses nano surface engineering nano surfeng developed engineering minor prepare undergraduate students surface processing characterization materials using modern nanotechnologies six courses taught undergraduate students four different engineering departments authors institution effectiveness nano surfeng curricula evaluated using students responses course evaluation survey course kruskal wallis test dunn post hoc test used combination determine impact students major background identify significant majors welch test used evaluating significance difference students high gpa group students relatively low gpa group major engineering background students found critical factor affects students performance acquisition knowledge six nano surfeng students materials engineering background advantage obtain high grade high level courses students gpa different levels impact effectiveness learning nano surfeng courses students high gpa easily accommodated high level courses
previous studies shown capacitance throughput units used source output voltage signal satisfactory hop picking machine throughput control study investigated possibility capacitance throughput sensor integration appropriate location stationary hop picking machine possibility calibration possibility control procedure development performance verification operational conditions capacitance throughput sensor integrated pocket belt conveyor transports freshly picked hop material separation part machine control frequency converter powers electric motor pocket belt conveyor realized simple controller application graphic touch panel serving interface machine operator mathematical model capacitance sensor sensitivity distribution helped better understand function practical application pocket belt conveyor metal pockets linear dependence sensor output voltage wet hop material throughput determined throughput range suitable coefficient determination based calibration results harvesting losses measurement simple mode automatic control algorithm developed functioning control system observed picking hop plants one trailer ordinary harvesting day aim verify performance case throughput automatic control usage periods high material throughput rates higher cause losses occurred six times less comparison situation without control peaks harvesting losses dropped machine operator quickly evaluated situation spontaneously started use automatic control mode control system installed machine
current programming practical classes individual based consequently opportunity missed include collaborative learning environment work sets explore collaborative environment might encouraged one approach achieve use anonymous peer review code peer review needs integrated completion practical seen separate entity game elements potential allow extra work part practical motivating timely relevant manner paper presents web based system game elements computer programming practical lab environment students third level education system locks later parts lab student code reviewed anonymously peers lecturer locking mechanism encourages students review code aim create team atmosphere among students collaboration knowledge sharing important technical completion lab practical user test carried initial findings indicate increase student engagement study consisted class students computer graphics two hour programming practical class six steps complete conjunction students filling feedback form end lab data practical analysed effectiveness approach gauged
background liver hepatocellular carcinoma accounts overwhelming majority primary liver cancers belated diagnosis poor prognosis call novel biomarkers discovered era big data innovative bioinformatics computational techniques prove highly helpful methods big data aggregated cancer genome atlas natural language processing integrated generate differentially expressed genes relevant signaling pathways differentially expressed genes went gene ontology enrichment analysis kyoto encyclopedia genes genomes panther pathway enrichment analysis protein protein interaction network pathway ranked high enrichment analysis investigated selected genes top priority evaluated assessed terms diagnostic prognostic values results list genes generated overlapping genes cancer genome atlas natural language processing three pathways demonstrated top priorities one specific associations cancers pathways cancer analyzed four highlighted genes namely birc ccnei cdkna validated using oncomine detection pool composed four genes presented satisfactory diagnostic power outstanding integrated auc sensitivity specificity birc ccne associated poor prognosis cdkna demonstrated statistically significant differences discussion study illustrates liver hepatocellular carcinoma gene signatures related pathways networks perspective big data featuring cancer specific pathway priority pathways cancer detection pool four highlighted genes namely birc ccnei cdkna investigated given high evidence level diagnosis whereas prognostic powers birc ccnei equally attractive worthy attention
backgroundboth genetic environmental factors implicated etiology attention deficit hyperactivity disorder adhd previously suggested exposure maternal smoking pregnancy msdp may valid basis delineating distinct subtype adhd children exposed msdp present severe clinical picture examine psychopathology parents group better understand etiology adhd methodsusing family interview genetic studies sample families children adhd collected data pertaining lifetime parental psychopathology families stratified based maternal smoking complete gestational period frequency different disorders compared using statistic resultsin group mothers smoked pregnancy parents significantly likely antisocial personality disorder problems alcohol drug abuse mothers significantly higher frequency major depressive disorder mdd fathers showed trend mdd bipolar disorder conclusionsbased pattern psychopathology parents children exposed msdp well earlier reports severe clinical behavioral cognitive phenotype children combined large body epidemiological evidence propose children present distinct subtype adhd comorbid conduct disorder furthermore propose msdp may proxy measure help delineate subtype
development integrated circuits fully integrated continuous time filter focused widely nth order universal filter based current feedback operational amplifier cfoa proposed compared available circuits proposed circuit using less components cfoas capacitors resistors realize universal filter functions without changing circuit configuration operating frequency proposed filter circuit least mhz capacitors proposed circuit grounded another benefit integration point view pspice simulations carried using cmos technology sensitivity analysis proposed nth order low pass filter circuit completed elsevier gmbh rights reserved
background nutritional exposures utero development may long lasting consequences postnatal renal health animal studies suggest specifically maternal dietary protein intake pregnancy influences childhood kidney function objective examined associations total animal vegetable maternal protein intake pregnancy kidney volume function school aged children design study conducted pregnant women children participating population based cohort study early life onward first trimester energy adjusted maternal protein intake assessed food frequency questionnaire child age assessed kidney volume estimated glomerular filtration rate egfr using serum creatinine cystatin concentrations microalbuminuria using urine albumin creatinine ratios results first trimester maternal total protein intake associated higher childhood creatinine based egfr difference min min per gram protein intake association mainly driven vegetable protein intake min min per gram vegetable protein intake associations explained protein intake early childhood first trimester maternal protein intake significantly associated childhood kidney volume cystatin based egfr risk microalbuminuria conclusions findings suggest higher total vegetable animal maternal protein intake first trimester pregnancy associated higher egfr childhood follow studies needed investigate whether maternal protein intake early pregnancy also affects risk kidney diseases later life
comparative effectiveness analysis performed examine risks benefits laparoscopic bilateral tubal ligation compared hysteroscopic sterilization using essure permanent birth control system bayer healthcare whippany existing evidence shows lbtl essure safe effective methods female sterilization high rates efficacy low rates complications although complications occur related essure procedure likely minor nature analysis limited restricted number studies involving head head comparisons approaches aagl rights reserved
objective study investigate frequency traditional risk factors cardiovascular disease calculate systematic coronary risk evaluation score related mortality danish patients psoriatic arthritis psa ankylosing spondylitis compare results patients rheumatoid arthritis settlement psa patients aged years one outpatient clinic invited rheumatology nurse conducted min screening consultation preceded lipid glucose profile high score risk led recommendation follow general practitioners multiple logistic regression analyses adjusted age gender performed compare risk factors risk scores participants female psa female opposed psa patients lower year risk scores mortality patients versus coefficient confidence interval psa versus women psa increased waistline compared women psa versus increased prevalence hypertension seen versus patients traditional modifiable risk factors present psa patients psa patients estimated lower year risk mortality patients according score model adjusted age gender
timing critical trying engage students various engineering career paths many national engineers week programs exist primary middle school students lack hands activities students grades often difficult devise experiments age group interesting juvenile yet crucial years students lost science math engineering engaging students presenting opportunities invention excitement important teen years peer pressure distractions friends social events activities particularly high number open source programming affordable hardware platforms used implement low cost interactive programs promote innovation various age groups paper share work well learnings make workshops effective created various arduino projects customized grade levels ranging grades even college undergraduate students various projects describe paper used interact students different grade levels engage basic elements engineering computer programming classes set work groups promote shared innovation teamwork collaboration peers open source hardware experimenting exposed students various career paths ranging software engineer electronic engineers basic elements various engineering paths paper designed demonstrate promotion engineering profession schools use arduino uno raspberry gemma kits flora kits programs also designed accommodate classroom setting workshops class field trip
pathogenesis alzheimer disease involves multiple pathways macrolevel include decreased proliferation plus increased loss affecting neurons astrocytes capillaries subcellular level involve several elements amyloid amyloid precursor protein presenilins unfolded protein response ubiquitin proteasome system wnt catenin system notch signaling system mitochondria mitophagy calcium tau data presented show intimate anatomical interactions neurons astrocytes capillaries interactions several subcellular factors affecting cells treatments currently available might correct dysfunctions subcellular factors available treatments include lithium valproate pioglitazone erythropoietin prazosin since subcellular pathogenesis involves multiple interacting elements combination treatment would effective administration single drug directed element overall purpose presentation describe pathogenesis detail explain proposed treatments
background aims sitosterolemia displays high plasma total sterols high plant sterols normal high total cholesterol normal moderately elevated low density lipoprotein ldl levels high ldl intermediate density lipoprotein idl low density lipoprotein vldl particles low high density lipoprotein hdl increased non hdl ratios triglycerides hdl increase risk atherosclerosis ezetimibe eze reduce plasma levels sitosterolemia effect lipoprotein subclasses previously reported methods sitosterolemia patients taken eze weeks eze placed eze weeks eze serum lipids measured enzymatically lipoprotein subclasses assessed polyacrylamide gel electrophoresis results eze reduced total sterols ldl sterol sterol mass large vldl vldl remnants large idl compared eze eze affect large ldl subclasses mean ldl particle size angstrom eze increased hdl sterol including intermediate large hdl eze reduced non hdl sterol total sterols hdl hdl conclusions eze improves vldl hdl subfraction distribution thereby reducing atherogenic lipid profile thus providing potential clinical benefit sitosterolemia beyond reduction elsevier rights reserved
surface plasmons metal nanocrystals provide new opportunity converting solar energy chemical energy article outline mechanisms surface plasmons catalytic organic hydrogenation based recent studies efficient conversion solar chemical energy achieved paved way replacing heat based catalysis conventional chemical manufacturing solar energy providing guidance designing plasmonic catalytic materials
multiple sclerosis chronic autoimmune disease demyelination neurodegeneration central nervous system shown regulatory treg cells responsible maintaining tolerance self antigens suppress autoimmune process several animal models experimental auto immune encephalomyelitis eae mouse model recent basic studies demonstrated forkhead box foxp btb domain cnc homolog bach master transcription factors cells playing pivotal role polarization naive cells treg cells current study expression foxp bach genes foxp promoter methylation evaluated cells eae induced mice results study showed prominent significant hypermethylation foxp gene promoter eae induced mice compared sham control groups expression foxp bach genes significantly decreased eae group comparison sham control groups study suggests epigenetic modification foxp gene involved pathogenesis eae could important therapy appropriate logical statement elsevier rights reserved
meinong thought rediscovered recent times analytic philosophy object theory significant consequences formal ontology especially account impossible objects proved decisive wide range fields logic ontology fiction rejecting traditional prejudice favour real meinong investigates peculiar non existing object precisely fictional object exemplifies number properties like sherlock holmes lives baker street outstanding detective without existing way flesh blood detectives fictional objects sense incomplete objects whose core constituent properties completely determined imply hold fictional object may also occur true statements shall deal objections raised russell quine meinong view pointing limits advantages perspectives
critical onsets draw resonance instability occurring two dimensional film casting processes newtonian viscoelastic upper convected maxwell phan thien tanner fluids newly determined using transient frequency response method constant tension condition guarantees always stable operation trajectory transfer function output takeup velocity input tension nyquist plot used indicator finding draw resonance onsets various stability windows newtonian viscoelastic fluids constructed confirming onsets well predicted compared transient responses actual velocity controlled operating systems around onsets interestingly stability patterns along aspect ratio newtonian cases found closely related flow deformation features fluid elements within film width dichotomous stability behaviors extensional thickening extensional thinning fluids well addressed processes elsevier rights reserved
objective examine effect selenium supplementation cell counts viral suppression time antiretroviral therapy art initiation art naive hiv infected patients rwanda methods multicenter double blinded placebo controlled randomized clinical trial conducted eligible patients hiv infected adults years cell count cells art eligibility cells throughout trial willing practice barrier methods birth control patients randomized receive daily selenium tablets identical placebo followed months assessments every months declines cell counts modeled using linear regressions generalized estimating equations effect modification composite outcome art eligible art initiation using cox proportional hazards regression conducted intention treat results participants received selenium women median age years rate depletion reduced confidence interval decrease treatment arm mean cells per month mean cells per month observed composite outcome events treatment arm found treatment effect composite outcome hazard ratio viral suppression odds ratio trial powered composite outcome due lower anticipated event rate adverse events comparable throughout conclusions randomized clinical trial demonstrated month selenium supplementation significantly reduces rate cell count decline among art naive patients copyright wolters kluwer health inc rights reserved
banking reform banks industrial companies italy strongly intertwined terms ownership interlocking directorates using imita large dataset containing data directors italian joint stock companies paper analyzes would happened italian corporate network years german type universal banks directors would test shows new centers system would emerged financial electricity phone companies confirming interconnected nature italian capitalism also analyze two industries textiles iron steel characterized different labor capital intensities check sectoral differences contrary conventional wisdom find local banks important funding industries
paper proposes novel observer controller identification method identifying minimally realised equivalent reduced order mathematical models block observer controller canonical forms unknown open loop system existing feedback feedforward controllers iii observer based available measurements operating closed loop system skipping singular value decomposition procedure without involving model conversion identified model general coordinate block observer controller canonical forms identification process proposed method able directly realise identified parameters minimally realised block observer controller canonical forms simplifies system identification process new procedures enable enhance computational aspects designing self tuning controllers online adaptive control class multivariable systems improve tracking performance considerably result newly proposed compensation improvement approach able compensate undesirable operating controller
recently combination therapy involving cholinesterase che inhibitor neuroprotective agents shown better desirable effect management prevention dementia limited information available effect dietary polyphenols hence study sought assess combined pretreatment effect curcumin major polyphenolic compound turmeric curcuma longa rhizomes donepezil cholinesterase inhibitor cognitive function scopolamine induced memory impairment rats rats pretreated curcumin donepezil via oral administration seven successive days dementia induced end treatment period single injection scopolamine via intraperitoneal administration thereafter changes spatial episodic memory conducted estimation biochemical parameters associated cognitive function determined scopolamine treated rats showed impaired learning memory increased activities acetylcholinesterase ache butyrylcholinesterase buche adenosine deaminase ada lipid peroxidation concomitant decreased levels nitric oxide reduced glutathione gsh superoxide dismutase sod catalase activities compared control however combination curcumin donepezil improves learning memory activity associated inhibitory effect ache buche ada activities compared control addition combined pretreatment significantly decreased lipid peroxidation increased levels antioxidant status compared scopolamine treated rats finding supports concept combination strategy might alternative therapy management prevention neurological disorders thus observed anti amnestic effect could linked inhibitory effect key enzyme cholinergic system associated memory function
background examined association cardiovascular health younger ages proportion life lived free morbidity cumulative burden morbidity average healthcare costs older ages methods cha study chicago heart association detection project industry longitudinal cohort employed men women years age baseline examination baseline measurements included blood pressure cholesterol diabetes mellitus body mass index smoking individuals classified strata cardiovascular health favorable levels factors factors high elevated risk factors high risk factor high risk factors linked medicare national death index data used determine morbidity older age individual cause morbidity score cardiovascular morbidity score calculated international classification disease ninth revision codes year follow results included participants became years age representing original cha participants female white mean age years baseline favorable levels factors risk factors elevated levels high risk factor high risk factors favorable cardiovascular health younger ages extended survival almost years postponed onset cause cardiovascular morbidity years respectively resulting compression morbidity absolute relative terms translated lower cumulative annual healthcare costs favorable cardiovascular health medicare eligibility conclusions individuals favorable cardiovascular health early middle age live longer healthier life free types morbidity findings provide strong support prevention efforts earlier life aimed preserving cardiovascular health reducing burden disease older ages
previous publications widely reported hydroxyvitamin alpha hydroxylase cypb regulated metabolism hydroxyvitamin close association altered activity vitamin vascular calcification reported various human diseases including chronic kidney disease osteoporosis atherosclerosis vascular calcification clinically significant component atherosclerosis may promoted ros associated inflammatory study evaluated effect hydroxyvitamin alpha hydroxylase atherosclerosis disease apolipoprotein apo mice wild type mice also isolated endothelial cell ecs vascular smooth muscle cells vsmcs aortic wild type mice apoe mice respectively investigated parathyroid hormone pth cypb vitamin receptor vdr expressions apoe apoe vsmc higher wide type vsmcs however increased proliferation decreased apoptosis showed vsmc compared cells apo mice moreover index associated vascular calcification intracellular concentration alkaline phosphatase alp activity tested result suggested levels former index improved apoe apoe vsmc got similar conclusions pre treatment elsevier masson sas rights reserved
packet classification core function network security systems hence hardware based solutions packet classification accelerator chips ternary content addressable memory cam widely adopted high performance systems rapid improvement general hardware architectures growing popularity multi core multi threaded processors software based packet classification algorithms attracting considerable attention owing high flexibility satisfying various industrial requirements security network systems high classification speed algorithms internally use large tables whose size increases exponentially ruleset size consequently used large rulesets overcome problem propose new software based packet classification algorithm simultaneously supports high scalability fast classification performance merging partition decision trees search table partitioning based packet classification algorithms show good scalability cost low classification speed algorithm shows high classification speed irrespective number rules small tables short table building time test results confirm proposed algorithm enables network security systems support heavy traffic effective manner
several approaches proposed anonymize relational databases using criterion anonymity avoid disclosure sensitive information identification attacks relational database said meet criterion anonymity record identical least records terms quasi identifier attribute values anonymize transactional database satisfy constraint anonymity item must successively considered quasi identifier attribute process greatly increases dimensionality thus also computational complexity anonymization information loss paper novel efficient anonymization system called pta proposed anonymize transactional data small information loss also reduce computational complexity anonymization process pta system consists three modules pre processing module tsp module anonymity model anonymize transactional data guarantees least anonymity achieved pre processing module traveling salesman problem module anonymization module extensive experiments carried compare efficiency designed approach state art anonymization algorithms terms scalability runtime information loss results indicate proposed pta system outperforms compared algorithms respects
objective rendering algorithm compute photograph simulated reality entails finding paths along light flow set light sources camera purpose article present high level overview underlying physics analyze leads high dimensional integration problem typically handled using monte carlo methods following survey recent work path space markov chain monte carlo mcmc methods compute resulting integrals using proposal distributions defined sets light paths
chapter considers effect poisson ratio lateral deformation longitudinal waves prismatic bars consequent density change non dimensionalization adopted herein dimensionless velocity longitudinal wave constant poisson ratio based non dimensionalization incorporation density correction lateral inertia using strength materials approach gives dimensionless velocity decreases increases poisson ratio tensile compressive loads respectively pivot conditions take place considering density correction considering lateral inertia considering corrections analogy extended case plane waves dilatation density correction required thereafter revisit lateral inertia love rods provides combined effect density young modulus poisson ratio polar radius gyration wave number velocity longitudinal waves love rods
high level unwanted pregnancies among young women urgent public health problem south africa study sought establish awareness utilisation attitude towards use emergency contraception among patients seen commercial city reproductive health clinic durban south africa cross sectional descriptive study conducted means self administered questionnaire among sexually active females ages years two thirds participants heard among used among heard heard clinics two thirds participants knew correct timing taken following sexual intercourse majority indicated used prevent unplanned pregnancy majority participants displayed positive attitude towards use third participants reported cultural beliefs religions majority also indicated recommend women family planning method awareness utilisation good among participants women displayed positive attitudes towards perceived beneficial health professionals inform alert women clients consequences unprotected sex guide make informed choices means adequate information regarding
anti atrial fibrillatory proarrhythmic potentials amiodarone simultaneously analyzed using halothane anesthetized beagle dogs order begin prepare standard protocol clarifying efficacy adverse effects anti atrial fibrillatory drugs intravenous administration amiodarone hydrochloride decreased heart rate mean blood pressure additional administration amiodarone hydrochloride prolonged interval besides effects observed low dose whereas showed times larger prolongation effective refractory period atrium ventricle may explain clinical efficacy atrial arrhythmias however significant change detected either dose early repolarization assessed corrected peak late repolarization done peak end electrocardiogram although former tended shortened reverse true latter lack prolongation early repolarization make feasible better understand amiodarone lacks proarrhythmic potential spite interval prolongation thus results amiodarone obtained current protocol may become guidance assessing efficacy adverse effects new anti atrial fibrillatory drugs vivo
goal study understand characteristics high average low level performing students first year computer programming course investigate whether performance predicted accurately early enough semester timely intervention triangulate data three sources submission steps outcomes automatic marking system provides instant feedback assessment marks semester student engagement discussion forum piazza define extract attributes characterizing student activity performance discuss distinct characteristics three groups using attributes built compact decision tree classifier able predict exam mark accuracy end semester middle semester discuss important predictors analysis used improve teaching learning
background bipolar disorder associated chronic low grade inflammation several medical comorbidities decreased life expectancy metabolic inflammatory changes postulated one main links medical comorbidity although studies exploring possible mechanisms underlying relationship therefore aims current narrative review synthesize evidence metabolic inflammatory changes may facilitate link medical comorbidity discuss therapeutic preventive implications pathways methods pubmed google scholar databases searched relevant studies results identified studies suggested increased risk medical comorbidities autoimmune disorders obesity diabetes cardiovascular disease patients association general medical comorbidities seems bidirectional potentially mediated immune dysfunction targeting metabolic inflammatory mood pathway may potential yield improved outcomes however study needed determine specific interventions may beneficial limitations majority identified studies cross sectional designs small sample sizes limited measurements inflammation conclusions treatment prevention general medical comorbidities mood disorders include preferential prescribing metabolically neutral agents adjunctive lifestyle modifications including increased physical activity improved diet decreased substance abuse addition use anti inflammatory agents could relevant therapeutic target future research
psychoanalytic work help people meaningfully engage aspects psychotic experience feel overwhelming however contact possible offer practice acceptable potential patients family team social groups exist within psychoanalytic community failing partly political terrain also due perceived unapproachability argue type tentative humble positions advocated approaches open dialogue allows psychoanalytic techniques palatable experiencing psychosis especially important given language functions psychosis histories intrusion oppression language interacts clinical material work female patient suffering paralysing visual hallucinations discussed particular emphasis contact possible certain discourse knots deconstructed work requires giving traditional ideas around technique interest serving one disenfranchised client groups
background observational studies osteoporotic fractures patients type diabetes indicate increased incidence compared without diabetes results inconsistent currently type diabetes considered independent risk factor low energy fractures elder subjects aim study assess association type diabetes risk hip vertebral fractures postmenopausal women materials methods searched medline web science cochrane databases articles published september studies assessing fractures women aged diagnosed type diabetes regardless diabetes treatment deemed eligible estimate fracture risk meta analysis random effect model performed results shown odds ratio confidence interval heterogeneity tested using cochrane test significance analyzed measure results total observational studies cohort cross sectional diabetics controls included thirteen papers provided information incidence hip fractures seven vertebral ones meta analysis revealed type diabetes associated higher risk hip fracture vertebral fracture significant heterogeneity hip fracture studies american origin identified potential source heterogeneity conclusions results meta analysis indicate increased risk hip fracture postmenopausal women type diabetes
paper includes comparative analysis environmental energetic financial costs different bus propulsion possibly applied public transport city belgrade considers modern diesel bus trolleybus natural gas bus spark ignition engine electric bus using lifepo battery electric bus ultra capacitor results presented according real data real electro energetic situation serbia dominantly used lignite coal primary fuel model gives exact exhaust emission electric vehicles thermal power plant enables comparison internal combustion engine vehicles result analysis shows natural gas bus cost efficient economical way overall exploitation price per trolleybus economical natural gas powered bus high departures rate higher per workday
background level serum lipids reported associated depression suicidality exact relationship factors remains controversial aim study investigate association lipid levels depression suicidality large sample methods examined association serum lipid levels existence mild depression measured using patient health questionnaire phq national sample korean data men women participated korea national health nutrition examination survey knhnes used serum concentration high density lipoprotein cholesterol hdl low density lipoprotein cholesterol ldl triglyceride total cholesterol dichotomized complex samples logistic regression employed analysis results significant association high level hdl depression adult men high level triglyceride depression adult women middle aged adults year increased level depression suicidality related high level triglyceride respectively depression suicidality furthermore found increased number abnormal lipids level significantly associated increased prevalence depression women middle aged adults limitations study cross sectional design hard investigate causation lipid levels depression assessment suicidality needs validation conclusion findings support significant association high level hdl triglyceride depression large sample data triglyceride highly associated suicidality younger middle aged adults elderly adults assessment could delineate relationship serum lipid levels depression suicidality ethnic groups
paper presents mathematical model find wheel location grinding given helical flute end mill two new setting parameters introduced define relative wheel location workpiece coordinates model allows wheel axis orientation expressed explicitly function design factors machine setting parameters utilizing explicit form wheel orientation analyzing influence setting parameters design parameters new efficient search algorithm proposed performance shows required wheel location found within machine given flute profile moreover rake angle produced precisely compared conventional methods used approximations comprehensive development software designing grinding helical flute end mill presented provides technology good foundation development computer aided design computer aided manufacturing cad cam system manufacturing end mills results experiment simulation design compared order verify proposed method
research investigated baseline impulsivity rejection sensitivity reactions stressors individuals borderline personality disorder compared healthy individuals avoidant personality disorder borderline group showed greater impulsivity avoidant healthy groups delay discounting task real monetary rewards self reported reactions stressors moreover findings could explained occurring substance use disorders distress reactions stressors equally elevated personality disorder groups relative healthy group borderline avoidant groups also reported maladaptive reactions stressor interpersonal versus non interpersonal nature whereas healthy group finally self reported impulsive reactions stressors associated baseline impulsivity delay discounting task greater self reported reactivity interpersonal non interpersonal stressors associated rejection sensitivity research highlights distinct vulnerabilities contributing impulsive behavior borderline personality disorder
utero exposure valproic acid vpa may cause symptoms related autism spectrum disorder asd abnormal serotonergic system implicated etiology asd present study examined expression distribution two early inducers neurons rat embryos elucidate prenatal development neurons vpa exposure embryonic day whole embryo situ hybridization showed expression sonic hedgehog one early inducers neurons reduced around isthmus vpa exposed group furthermore whole mount immunohistochemistry hindbrain quantitative analysis neurons rostral raphe nucleus rrn revealed neuronal distribution caudal part rrn narrower vpa exposed group controls thus early development neurons altered vpa exposure utero observed prenatal alteration may significant etiology autism isdn published elsevier ltd rights reserved
scene text information extraction plays important role many computer vision applications features existing text extraction algorithms applicable one text extraction stage text detection recognition significantly weakens consistency end end system especially complex chinese texts tackle challenging problem propose novel text structure feature extractor based text structure component detector tscd layer residual network chinese texts inspired three layer chinese text cognition model human combine tscd layer residual network extract features suitable text extraction stages specialized modeling chinese characters tscd layer simulates key structure component cognition layer psychological model residual mechanism residual network simulates key bidirectional connection among layers psychological model organic combination tscd layer residual network extracted features applicable text detection recognition humans evaluation text detection recognition models based proposed text structure feature extractor achieve great improvements baseline cnn models end end chinese text information extraction system experimentally designed evaluated showing advantage proposed feature extractor unified feature extractor
dementia global health problem huge impact lives afflicted several distinct diseases classified umbrella term dementia ranging neurodegenerative disorders alzheimer disease chronic infections central nervous system subacute sclerosing panencephalitis sspe rare complication measles virus infection childhood clinical features neuropsychological profiles imaging characteristics various dementia syndromes sufficiently distinct distinguish one another however cases cognitive psychiatric behavioural features sufficiently overlap neurophysiologic testing may help recognized electroencephalogram eeg may special role play diagnosis certain dementing illnesses sspe creutzfeldt jakob disease cjd characteristic eeg changes current research focusses potential utility quantitative eeg one tool armamentarium clinicians dealing patients suffer dementing illness searched pubmed cochrane database january january combining search terms eeg electroencephalography dementia status epilepticus identified papers searches read detail summarized discuss qualitative quantitative eeg findings various types dementia
impulsive behavior underlying brain processes hypothesized central development maintenance pathological gambling inhibition ability differentially impaired pathological gamblers pgs goal cross sectional study compare common inhibition measures discrimination healthy controls performed response inhibition interference inhibition stroop reflective inhibition matching familiar figures mfft tasks augmented total interference response time stroop task eta high number commission errors eta task total number errors mfft eta discriminate pgs slow response time task eta borderline ability number errors incongruent condition total interference terms error rate number omissions task first response time mfft could differentiate significant correlations inhibition measures inhibition measures relevant gambling pgs express rash impulsive behavior quick answer without thinking contrary inhibition impairment related slow inaccurate performance elsevier ltd rights reserved
self definition becomes central task early adolescence youth identify multiple social groups focusing ethnic identification identification salient social ingroups based extracurricular activities examined predictors perceived ingroup membership overlap among ethnically diverse adolescents age female social ingroup overlap remained relatively stable decreased across seventh eighth grade number cross ethnic classmates seventh grade predicted lower overlap eighth grade cross ethnic friendships eighth grade mediated association findings underscore opportunities provided multiethnic middle schools youth connect befriend one another across ethnic lines well foster divergent social identities associated positive intergroup attitudes
humans seem place positive reward value prosocial behavior evidence suggests prosocial inclination driven reflexive tendency share observed sensations emotions behavior others self resonance study examine neural correlates self resonance relate prosocial decision making subjects performed two tasks undergoing fmri observation human hand pierced needle observation imitation emotional facial expressions outside scanner subjects played dictator game players low high income represented neutral expression headshots subjects offers dictator game correlated activity neural systems associated self resonance anticorrelated activity systems implicated control pain affect imitation functional connectivity areas involved self resonance top control negatively correlated subjects offers study suggests interaction self resonance top control processes important component prosocial inclinations towards others even biological stimuli associated self resonance limited findings support view prosocial decision making grounded embodied cognition hum brain mapp wiley periodicals inc
purpose purposes paper investigate schedule performance new retrofitting green building projects identify critical factors influence schedule performance new retrofitting green building projects provide solutions improve schedule performance new retrofitting green building projects design methodology approach questionnaire survey conducted responses received firms experienced green building projects singapore data survey analyzed face face interviews conducted two senior project managers solicit comments survey results findings study identified degree project delay new green building projects retrofitting green building projects singapore result indicated percent singaporean green building projects plagued delay retrofitting projects significantly higher likelihood delay significantly longer extension new projects addition consultant cooperation solve problems influential schedule performance new retrofitting green building projects two project groups agreed overall ranking factors affecting schedule performance research limitations implications may geographical limitation conclusions drawn findings also sample size still small despite relatively high response rate addition majority respondents contractors project players reluctant respond survey practical implications study provides clear understanding schedule performance green building projects well critical factors highlighted constructing green building projects also strategies overcome negative impact factors allow practitioners better deal potential causes delay attain schedule performance originality value although construction delays widely investigated previous studies relating construction management attempted analyze schedule performance new retrofitting green buildings thus study adds significantly existing research green building construction delay
background depression among patients acute myocardial infarction ami prevalent associated adverse quality life prognosis despite recommendations national organizations screen depression unclear whether treatment depression patients ami associated better outcomes aimed determine whether prognosis patients treated versus untreated depression differs methods triumph study translational research investigating underlying disparities acute myocardial infarction patients health status observational multicenter cohort study enrolled patients aged years ami april december hospitals research coordinators administered patient health questionnaire phq index ami admission depression defined phq score depression categorized treated documentation discharge diagnosis medication prescribed depression referral counseling untreated none criteria documented medical records despite phq score one year mortality compared patients ami depression phq reference treated depression untreated depression adjusting demographics ami severity clinical factors results overall patients met phq criteria depression treated comparison patients without depression patients treated depression year mortality rates different versus adjusted hazard ratio confidence interval contrast patients untreated depression higher year mortality comparison patients without depression versus adjusted hazard ratio confidence interval conclusions although depression patients ami associated increased long term mortality association may confined patients untreated depression
objectives although much published demographic clinical characteristics elderly patients overactive bladder oab enrolled clinical trials little known general population elderly americans oab update gap literature using real world data describe population methods used medicare claims medicare current beneficiary surveys identify patients oab describe demographic characteristics functional impairment physical limitations concurrent medical conditions charlson comorbidity index cci scores concomitant medication use patients oab characteristics also described sex age group years also compare characteristics oab non oab patients results identified elderly patients oab average age years female without oab average age years female patients oab reported high levels functional impairment measured activities daily living non oab patients instrumental adl non oab patients physical functioning limitation non oab patients scales elderly patients oab also experienced high levels comorbidity burden measured number medical conditions non oab patients cci non oab patients number non oab related concomitant medications used non oab patients conclusions elderly patients oab general population high levels functional impairment physical limitations comorbidity concomitant medication use characteristics taken consideration managing oab symptoms designing future clinical studies results representative elderly patients oab general population however interpreted light key limitations data used patients may misclassified medical conditions overestimated due artifacts diagnosis coding results generalized patients enrolled medicare parts least continuous months
present study intended examine efficacy safety bendamustine monotherapy patients previously untreated chronic lymphocytic leukemia cll treatment fludarabine flu suitable flu patients relapsed refractory cll intravenously administered bendamustine day days day cycle patients eight previously untreated two relapsed refractory six cycles primary endpoint overall response rate orr partial remission better according international workshop cll guidelines orr confidence interval neither disease progression mortality occurred follow therefore medians progression free survival duration response overall survival estimated exceed months respectively adverse events aes occurred patients grade hematologic aes included lymphopenia neutropenia lymphopenia leukopenia nonhematologic aes included constipation nausea malaise anorexia one case grade infection adenocarcinoma stomach bendamustine showed high efficacy japanese patients previously untreated relapsed refractory cll safety profile acceptable
aim less worlds described plant species assessed iucn red list leaving many species invisible conservation prioritization large scale red list assessment plant species challenge species ranges resolved coarse scale geographic distribution key assessment criterion iucn red list evaluate use coarse scale distribution data predictive models assess global scale drivers extinction risk economically important plant group bulbous monocotyledons location global methods using coarse scale species distribution data train machine learning model biological environmental variables species assessed iucn red list order identify correlates extinction risk predict extinction risk bulbous monocot species best models map predictions identify potential hotspots threat results model achieved classification accuracy threatened species non threatened species accurately predicted model predicted bulbous monocots presently evaluated iucn criteria threatened human impacts key correlate threat spatial analysis identified hotspots threat bulbous monocots yet iucn red list example central chile main conclusions first time machine learning model used determine extinction risk global scale species rich plant group coarse scale distribution data exist many plant groups methods replicated provide extinction risk predictions across plant kingdom approach used low cost prioritization tool targeting field based assessments
focusing relevant information suppressing irrelevant one critical abilities different cognitive processes however functioning scarcely investigated working memory domain healthy pathological conditions present research aimed study abilities aging parkinson disease testing three groups healthy participants young older elderly one patients employing new experimental paradigm results showed transient storing irrelevant information causes substantial interference effects remarkable elderly individuals response latency accuracy interestingly patients responded faster equally accurate compared matched control group taken together findings confirm existence similar mechanisms orienting attention inwards contents outwards perceptual stimuli suggest suitability task assess functioning healthy aging
context solar energy exploitation dye sensitized solar cells dye sensitized photoelectrosynthetic cells offer promise low cost sunlight conversion storage respectively perspective discuss main successes limitations modern computational methodologies ranging hybrid long range corrected density functionals approaches multi reference perturbation theories describing electronic optical properties isolated components complex interfaces relevant devices computational modelling crucial role development dye sensitized solar cells technology theoretical characterization interface structure interfacial processes water splitting devices still infancy especially concerning electron hole transfer phenomena quantitative analysis interfacial charge separation recombination reactions multiple metal oxide dye catalyst heterointerfaces thus undoubtedly represents compelling challenge field modern computational material science
background skin conditions dermatological diseases associated advanced age fungal infection dry skin itch receive increasingly attention clinical practice research cost economic evaluations important sources inform priority setting ressource allocation decisions healthcare economics skin conditions aged populations systematically reviewed far objectives aim mapping review summarize economic evidence selected skin conditions aged years methods mapping literature review evidence summary conducted searches conducted data bases medline embase via ovid cinahl searched using ebsco references lists potential eligible studies reviews guidelines sources screened additional literature evaluation methodological quality full economic analyses consensus health economic criteria chec checklist used results database searches resulted records total articles read full text thirtyfive publications finally included data analysis reporting economic analyses ten cost illness analyses cost effectiveness analyses reporting pressure ulcers skin tears pressure ulcers incontinence associated dermatitis intertrigo contact dermatitis candidiasis treatment prevention onychomycosis testing identified limited evidence indicated low air loss beds cost effective standard beds prevention pressure ulcers standardized skin care regimens seem lower incidence pressure ulcers skin tears iad cost saving effect always observed conclusions findings mapping review indicate paucity high quality evidence regarding economic impact age associated skin conditions diseases substantial heterogeneity terms study design evaluation perspective time period way cost estimation identified overall low methodological quality clear cut conclusions drawn robust large scales economic evaluations skin conditions disease aged populations needed future tissue viability society published elsevier ltd rights reserved
psychopathic individuals identified contemporary instruments vary considerably personality etiological background creates confusion practice inconsistency data goal paper clarify heterogeneity introduce new typology narrow psychopathic subcategories towards end discuss conceptual history psychopathy compare construct validity different psychopathy measures dsm pcl ppi tripm review cluster analytic studies identify homogenous categories line existing literature psychopathic population broadly divided primary secondary category diverge crucially personality reward punishment sensitivity neuroticism impulsivity hostility etiology genetic contributions fronto limbic circuitry serotonergic functioning testosterone cortisol endocrinology secondary psychopathy may situated continuum antisocial borderline personality disorder represents severe qualitatively different form environment contingent emotional disturbance prefrontal cortex malfunctioning serotonin deficiency impaired predictive allostasis whereas primary psychopathy unique condition strongly rooted constitutionally defined emotional deficiency limbic hyporesponsivity serotonin hyperstability dampened reactive allostasis however primary secondary psychopathic samples show high levels withingroup heterogeneity may placed continuum respectively self control affect instability concluding introduce new continuum primary psychopathy controlled disinhibited secondary psychopathy detached unstable discuss subtypes may differ number psychopathy measures personality profiles endophenotypic pathways finally future directions resolving conceptual issues discussed elsevier ltd rights reserved
background psychological stress adolescence natural phenomenon issues related academics parents peers social life personal doubts always created queries young minds times get neglected care givers psychological stress tends unchecked among school students much work done area stress levels interventions among indian adolescents primary objective test effectiveness life skill training program reducing stress among adolescents methods forty two adolescent boys participated study prevalence stress determined administering standardized stress questionnaire intervention program consisted seven daily sessions minutes conducted within school timings life skills stress management modules nimhans model selected address adolescent stressors spss used data entry analysis pre post three month follow assessments conducted results adolescents reported stressed mean stress scores among adolescents underwent intervention program reduced significantly post one month post three month follow conclusion results suggested group based stress management programs conducted regularly would beneficial reduce stress levels positive feedback students suggested activities feasible acceptable
last decades asthma sleep disordered breathing sdb children experienced similar increases prevalence shown airway inflammation leading investigators postulate association asthma sdb however whether relationship causal needs proven manuscript use widely accepted epidemiologic criteria causality bradford hill criteria test step step whether relation asthma sbd children causal found studies supporting criteria strength consistency specificity biological gradient coherence biological plausibility experiment analogy association asthma sdb however find study showing temporality directionality asthma sdb therefore establishing causal association asthma sdb yet possible published elsevier ltd
paper deals approach modelling view control embarked networks described strongly coupled multi sources multi loads systems nonlinear badly known characteristics model representative system behaviour easy handle easy regulators synthesis first step alternator modelled linearized around operating point subdivided two lower order systems according singular perturbation theory rst regulators designed subsystem tested means software test bench allows predicting network behaviour steady transient states finally designed controllers implanted experimental benchmark constituted two alternators supplying loads order test dynamic performances realistic conditions isa published elsevier ltd rights reserved
pkc essential neutrophil macrophage functions required host defense fungal pathogens type lectin receptor dectin integrin mac key roles controlling fungal infection demonstrate dectin mac induced activation protein kinase neutrophils independent card adaptor required reactive oxygen species production intracellular killing upon candida albicans uptake protein kinase also required zymosan induced cytokine generation neutrophils macrophages protein kinase deficiency prevented fungi induced reactive oxygen species generation effect activation tgf activated kinase effector card nuclear factor activation affect phagolysosomal maturation autophagy intracellular albicans killing vivo protein kinase deficient mice highly susceptible albicans aspergillus fumigatus infection partially rescued adoptively transferred wild type neutrophils thus protein kinase activation downstream dectin mac important role neutrophil macrophage functions required host defense fungal pathogens
background accumulating evidence suggests fetal exposure maternal psychiatric symptoms associated future risk psychopathology one potential pathway distress linked constriction uterine umbilical blood flow ubf approximately pregnant women taking antidepressant ecologically valid investigation hypothesis must consider potential concomitant influence pharmacotherapy ubf methods pregnant women lifetime histories mental illness evaluated every weeks gestation mood symptoms medication use women underwent ultrasound examination ubf approximately weeks gestation results associations observed ubf three assessments maternal prenatal depression anxiety acute coincident ubf scan proximal within weeks scan chronic serial symptom ratings chronic acute use bupropion associated reduced ubf even controlling pregnancy complications chronic use atypical antipsychotics also associated decreased ubf associations serotonergic antidepressant use ubf conclusions contrary popular hypothesis depression anxiety associated reductions ubf may pathway risk conferred prenatal development however requiring replication findings suggest prenatal bupropion exposure may associated reductions ubf
angioedema unique clinical presentation unchecked release bradykinin origin clinical presentation either genetic acquired outcome within patient subcutaneous swelling lower layers epidermis symptoms often localized upper airway gastrointestinal tract typical course resolves days patients clinical manifestations exist weeks hereditary rare genetically linked typically patient episodes many years diagnosis episodes acquired may drug induced triggered specific allergen idiopathic angioedema elicit need critical care interventions advanced airway management unnecessary abdominal surgery treatment patients evolving new pharmacological agents developed article addresses subtypes triggers pharmacology information interdisciplinary team planning individualized case management
objectives develop provide validity evidence performance checklist evaluate child abuse screening behaviors prehospital providers methods checklist development developed first iteration checklist review relevant literature basis authors clinical experience next panel six content experts participated three rounds delphi review reach consensus final checklist items checklist validation twenty eight emergency medical services ems providers emt basics emt paramedics participated standardized simulated case physical child abuse infant followed one one semi structured qualitative interviews three reviewers scored videotaped performance using final checklist light kappa cronbach alpha calculated assess inter rater reliability irr internal consistency respectively correlation successful child abuse screening checklist task completion participant characteristics compared using pearson chi squared test gather evidence construct validity results delphi review process resulted final checklist included items classified trichotomous scoring done done applicable overall irr three raters using light kappa indicating substantial agreement internal consistency checklist low overall cronbach alpha participants successfully screened child abuse simulation participants successfully screened child abuse differ significantly failed screen terms training level past experience child abuse reporting self reported confidence detecting child abuse tasks task exposing infant significantly correlated successful detection child abuse conclusions developed child abuse checklist demonstrated strong content validity substantial inter rater reliability successful item completion correlate markers provider experience validated instrument important potential training continuing education research prehospital providers levels training
article method measurement linear frequency response weakly non linear systems described frequency domain estimator developed analyzing output spectra single multitone excitations several types system models complex system one parallel cascade wiener hammerstein type model able represent wide range weakly non linear systems shown output spectrum weakly non linear system expressed polynomial constant coefficients given input signal frequency leads proposed polynomial estimator capable identifying true linear nonparametric frequency response system test special versions either input output noise developed consistency shown considered system models
managing engineering interfaces mass rapid transit mrt projects difficult exhausting work thousands complex interrelated construction interfaces embedded among multiple subworks subsystems interfaces revealed thoroughly preplanned achieve timely execution generate countless disputes among project parties delay overall progress considerably paper discusses stepwise procedure provide empirical comprehensive solution managing engineering interface mrt projects proposed procedure involves four steps identification key interface correlation work scope using work breakdown structure allocation interface scope responsibilities criteria using phase approach preplanning interface work items setting interface organizations using veto authorization proposed method suitable design build design bid build mrt contracts thereby benefiting practitioners interface management relevant field american society civil engineers
output system identification attractive technique implementation simplicity however requires long records validate white noise assumption excitation mainly transient forced vibration alternatively free vibration record segments selected identification process improves accuracy even using less data requires human intervention input recording present paper approach proposed accurate system identification short output records vibration induced transient excitation without human intervention approach based novel heuristic search algorithm find free vibration record segments fully automatic handles possibility free vibration absence tests real life data structural health monitoring shm bridge showed free vibration finding improves accuracy modal parameter estimates ten times compared using record segments starting response peak proposed approach drastically reduces need transmit large amounts data impacts hardware requirements shm implementations elsevier ltd rights reserved
years hydrogeomorphological mapping france considered efficient method flood mapping contributes sustainable land development taking account occurrences extreme events european floods directive requires production maps showing water depths extreme flood events article provides overview numerical floodplain models nfm methodology uses hydrogeomorphological observations lidar dem data produce water depth mapping article focuses nfm realised meurthe river close city nancy france nfm methodology initially charts floodplain hydrogeomorphological mapping uses simple hydraulics validation finally produces water depth maps gis processing resulting nfm shows good agreement historic flood methodology simple complementary solution hydraulics modelling provides better way communicate information extent extreme floods shows importance hydrogeomorphology flood hazard study management elsevier ltd rights reserved
objective study conducted determine effect cognitive behavioral stress management cbt reducing psychological stress diabetic pregnant women method randomized controlled trial applied pretest post test control group conducted eligible women gestational diabetes women stress score randomly assigned intervention control groups intervention group received stress management training within six two hour sessions three weeks stress fbs measured intervention two weeks last session data analyzed using spss version results analyzed using chi square paired test independent sample test results cbt training group stress significantly decreased two weeks training control group stress scores significantly different intervention women significant increase stress scores significant difference two groups stress scores two weeks intervention conclusion cognitive behavioral stress management reduces stress women gestational diabetes reducing stress may also improve pregnancy outcomes especially whose glycemic along stress adequately controlled medication
background functional connectivity density fcd could identify abnormal intrinsic spontaneous activity whole brain seed based resting state functional connectivity rsfc could reveal altered functional network identified brain regions may effective assessment strategy headache research study investigate rsfc architecture changes brain patients medication overuse headache moh using fcd rsfc methods methods structure images resting state functional mri data obtained moh patients episodic migraine patients normal controls ncs fcd calculated detect brain regions abnormal functional activity whole brain seed based rsfc performed explore functional network changes moh results decreased fcd located right parahippocampal gyrus increased fcd located left inferior parietal gyrus right supramarginal gyrus moh compared right caudate left insula moh compared rsfc revealed decreased functional connectivity brain regions decreased fcd anchored right dorsal lateral prefrontal cortex right frontopolar cortex moh left temporopolar cortex bilateral visual cortices compared frontal temporal parietal pattern moh compared conclusions results provided evidence moh suffered altered intrinsic functional connectivity architecture current study presented new perspective understanding neuromechanism moh pathogenesis
cross linked polyhedral oligomeric silsesquioxane poss nanohybrid synthesized schiff base chemistry using octa amino poss building blocks glutaraldehyde dual functional reagent obtained nanohybrid characterized solid state nmr sem tem tga adsorption desorption isotherm results demonstrate successful cross linkage poss molecules forming block like irregular nanoparticles specific surface area novel solid phase adsorbent cross linked poss nanohybrid exhibits selective adsorption properties acidic dyes methyl orange present case strong electrostatic interactions species nanohybrid main driving forces adsorption kinetic data well described pseudo second order kinetic model adsorption isotherm studies demonstrate data well fit langmuir model maximum adsorption capacity obtained thermodynamic studies indicate adsorption spontaneous exothermal along reduced randomness adsorbed species could effectively recovered using methanol naoh viv mol naoh eluent practical application textile wastewater treatment demonstrates cross linked poss nanohybrid appears promising material dye removal field elsevier inc rights reserved
software engineering means applying engineering principles software development way agile software engineering means applying agile approaches software engineering software engineering courses try teach software development life cycle using project based approaches also endeavor include real life issues software engineering courses moreover struggle teach teamwork software development requirement real life software development robotics education competition based learning efficiently used years competitions organized teams real world issues simulated work competition based learning approach applied agile software engineering course increase efficiency teaching software engineering results approach presented real world issues agile software development simulated using competition based setting wiley periodicals inc
report occurrence vibrational resonance piecewise linear non autonomous system especially show optimal amplitude high frequency second harmonic driving enhances response piece wise linear non autonomous murali lakshmanan chua mlc system low frequency first harmonic signal phenomenon illustrated analytical solutions circuit equations characterising system finally compared numerical method enunciated explicitly implementation fundamental nand gate via vibrational resonance numerical analytical solutions addition logical behaviours nand decided amplitude input square waves without altering system parameters elsevier rights reserved
control glass transition temperature functionalized polymers crucial materials engineering pharmaceutical applications tailoring must overcome experimental theoretical issues regarding thermodynamical phenomena involved work study glass transition poly monoitaconate poly diitaconate systems functionalized internal plasticization differential scanning calorimetry dsc raman spectroscopy used determine whereas thermal degradation analysis tga used determinate temperature limit conformers relax independently defined adams gibbs model results show values obtained dsc raman consistent tga used estimate lower bound limit mainly conclude larger steric hindrance carboxylic group side chain backbone increases decreases variation specific heat configurational entropy different domain regions similar behavior observed chlorine atoms substituted phenethyl groups elsevier rights reserved
green planning critically important design phases construction projects continually gets less attention construction project owners planners need understand communication influences green implementation address gap extant research paper presents evaluation results sustainability awareness field supervision personnel impacts successful completion school projects proving communicating sustainability goals vital decision making construction stage project paper uses data collected new school construction projects compare sustainability design goals successful incorporation completed projects seventy one project managers inspectors surveyed assess awareness key high performance sustainability requirements built designs responses two groups compared examine positive negative impacts analysis results show early continuous communication sustainability design goals field supervision personnel significant impact whether goals realized project turned owner occupancy successful implementation sustainability goals provides economic benefits fully exploiting life cycle costs also holds promise providing healthier working environment
modal identification civil engineering structures based ambient vibration measurement widely investigated past decades variety output operational modal identification methods proposed however vibration modes even fundamental low order modes always identifiable large scale structures ambient vibration excitation identifiability vibration modes deficiency modal identification criteria evaluate robustness identified modes applying output modal identification techniques ambient vibration responses scarcely studied study mode identifiability cable stayed ting kau bridge using ambient vibration measurements influence excitation intensity deficiency robustness modal identification investigated long term monitoring data acceleration responses acquired bridge different excitation conditions observed low order modes including second global mode identifiable common output modal identification algorithms normal ambient excitations due traffic monsoon deficient modes activated identified excitation intensity attains certain level strong typhoons reason low order modes fail reliably identified weak ambient vibration excitations relation mode identifiability excitation intensity addressed comparing frequency domain responses normal ambient vibration excitations typhoon excitations analyzing wind speeds corresponding different response data samples used modal identification threshold value wind speed generalized excitation intensity makes deficient modes identifiable determined
oil crisis environment pollution problem become increasingly prominent gaseous fuel internal combustion engines gas engines valued great resources potential feature low pollution gaseous fuel however average efficiency wasting large amount energy exhaust cooling water therefore effective way improving efficiency recover waste heat steam rankine cycle orc organic rankine cycle considered quite suitable methods whr waste heat recovery especially large engines whr system specific large gas engine orc advantages disadvantages gas engine rated power studied object paper according characters waste heat whr systems orc different working fluids including two stage organic rankine cycle dorc built math model compared aspects recovered power thermal efficiency system feasibility provides reference engineering application finally economic performance orc dorc evaluated compared elsevier ltd rights reserved
article describes computer aided design computer aided manufacture cad cam accuracy dental drill guides application guided surgery today availability three dimensional desktop printers allows cost effective production drill guides dental laboratories investigations show accuracy produced guides eliminating influencing factors exist guided surgery workflow investigate accuracy method developed evaluate cad cam production technology apart sources error cone beam computed tomography cbct scans intraoral scans software human error using cad cam milled idealized reference model well cad data scanned dental model integrated reference spheres drill guides different offset values designed using codiagnostix implant planning software bone level roxolid slactive implant system length diameter chosen virtual position relation drill guide reference model determined based planning data exported stl files respectively virtual physical measurements performed center coordinates used drill sleeves sleeve applying defined reference coordinate system rcs dental model drill guide templates printed using fotodent guide dental desktop printer based defined digital workflow insertion respective drill sleeves surgical guides secured reference models using quadrangular fixation thus allowing tactile measurement applying coordinate measurement device determination physical position relation central points drill sleeves coronal apical points planned implant drilling well angular deviation calculated reviewed cad measurements average deviation degrees planned implant detected
augmented augmented reality system making video appear come screen augmented television program viewed camera tablet related content three dimensional computer graphics dcg overlaid displayed tablet provide users age targeted content developed height estimation method based posture estimation method augmented height user estimated elevation tablet ground estimated user height used estimate age public testing carried around elementary school students data acquired used formulate relationship elevation tablet height user age estimation method proposed statistically likely age given height used therefore created table containing statistically likely age given height age user estimated using table evaluated accuracy height age estimations based results public testing error age estimation based height estimation years age rate age estimation case using age estimation method addition developing prototype application confirmed effectiveness methods
despite substantial progress understanding complex bio machinery involved regulation appetite energy homeostasis weight loss drugs currently government approved usa europe acknowledging novel drug monotherapies belviq saxenda review focuses various drug polytherapies currently attracting much research interest unfortunately however dependent variables new studies remain firmly rooted outcome measures reduced food intake bodyweight evidence clearly essential physiological data bearing upon potential target effects new treatment however emphasised many authors profiling matched sophisticated behavioural analysis addressing fundamental process questions reductions intake bodyweight achieved value behavioural analysis exemplified argued process led approach optimise translation preclinical clinical development candidate drugs avoid yet expensive blind alleys elsevier ltd rights reserved
lenalidomide without prednisone active therapy patients myelofibrosis provide update phase study lenalidomide plus prednisone patients median follow years forty patients enrolled study patients evaluable response response treatment reevaluated using iwg response criteria published quality response improved time overall response rate response splenomegaly seen patients anemia response median time treatment failure ttf patients months median duration response months response highly durable patients six patients ttf months years three patients still treatment beyond months years complete partial responses seen one five patients respectively achieving deeper response necessary response durable new clinical studies needed explore safe well tolerated lenalidomide based combination strategies patients elsevier ltd rights reserved
unusual reactions sensory input became part diagnostic criteria autism spectrum disorder dsm measures accurately assessing symptoms important clinical decisions study examined reliability validity sensory behavior questionnaire parent report scale designed assess frequency impact sensory behaviors autistic children scale demonstrated excellent internal consistency concurrent validity better predictor autistic symptoms short sensory profile within group school age autistic children scale also successfully discriminated autistic typical children similar age ability sensory behavior questionnaire potential measure sensory behaviors children autism spectrum
objective neurocognition known impact functioning individuals ultrahigh risk uhr psychosis studies investigating potential mediators relationship scarce building evidence schizophrenia spectrum disorders study tested whether negative symptoms social skills act mediators neurocognition functional outcome uhr individuals methods ultrahigh risk participants underwent neurocognitive testing using brief assessment cognition schizophrenia social skills negative symptoms assessed using high risk social challenge task scale assessment negative symptoms respectively four instruments used assess overall functioning one instrument assessed quality life encompassing social functioning results cross sectional analyses revealed neurocognition related measures functioning negative symptoms mediated relationship neurocognition four five measures functioning find social skills mediate neurocognition functioning conclusion negative symptoms appear mediate relationship neurocognition functional outcome uhr individuals finding needs confirmed extended longitudinal studies underscores importance focusing neurocognition negative symptoms aiming improving functional outcome uhr individuals
background aim iron deficiency anemia ida associated celiac disease although gluten free diet gfd efficient treatment ida remains occasional finding follow correlates inadequate gluten exclusion little known regarding persistent ida despite effective gfd aimed evaluate role small bowel capsule endoscopy sbce setting methods prospectively included consecutive patients undergoing gfd months persistent concomitant ida patients assessed serologically negative underwent endoscopic evaluation results twenty six patients underwent esophago gastro duodenoscopy egd colonoscopy sbce altogether patients resulted positive egd showed mucosal lesions erosive gastritis erosive duodenitis active colonoscopy showed hemorrhoids sbce positive cases erosive jejunitis eventually diagnosed refractory crohn disease angiodysplasias lymphangectasia overlap observed procedures since subjects egd sbce produced significant findings however cases sbce documented severe disease found egd hypoalbuminemia significantly associated positive sbce outcome conclusion sbce yielded significant findings celiacs persistent ida despite adequate gfd associated hypoalbuminemia indicating occurrence severe stages disease editrice gastroenterologica italiana published elsevier ltd rights reserved
background detection celiac disease suboptimal aims hypothesized misdiagnosis leading diagnostic delays examine assertion determining patients increased risk abdominal surgery diagnosis methods biopsy reports sweden pathology departments identified individuals marsh stage using hospital based data inpatient outpatient surgery recorded swedish patient register compared abdominal surgery appendectomy laparotomy biliary tract surgery uterine surgery controls matched age sex county calendar year conditional logistic regression estimated odds ratios ors results individuals controls record earlier abdominal surgery risk estimates highest first year surgery appendectomy laparotomy biliary tract surgery uterine surgery associated later diagnosis note abdominal surgery also common diagnosis hazard ratio conclusions increased risk abdominal surgery diagnosis surgical complications associated may best explain outcomes medical nihilism lack awareness may contributing outcomes editrice gastroenterologica italiana published elsevier ltd rights reserved
study novel waste heat recovery system comprises transcritical carbon dioxide rankine cycle stage reheat stage turbine carried power generation system converts waste heat electric power theoretically applied cooling water scavenge air engine water jacket main engine teu container ship propulsion stand alone type thermodynamic performance depending changes dimensionless turbine inlet pressures investigated results showed heat recovery system could produce maximum net output representative operation condition main engine moreover considering variation seawater temperature ship regular route found maximum output inversely proportional dimensionless temperature seawater based energy analysis cycle system efficiencies maximized respectively respect heat effectiveness based exergy analysis maximum efficiencies exergy system exergy respectively respect exergy effectiveness initial condition energy analysis result detailed analysis importance confirmed optimal output assignment stage turbine considering minimization exergy destruction reheater required order achieve maximum performance present system elsevier ltd rights reserved
fatherhood turning point life many men men lacked father figure growing birth child may catalyst fresh start researchers called qualitative investigations african american fathers parenting beliefs practices consider social contexts within broader research discourse parenthood investigations inform way frame african american fathers research thereby improving theoretical suggestions better supporting black men roles caretakers present case study details experiences young african american man tron participating larger church based intervention program focused strengthening father child relationships among african american families findings highlight tron story serves positive counternarrative prevailing negative stereotype african american men absentee parents thematic coding analysis revealed several major themes current article focuses tron decisions transform experience growing without father dedicated resolve remain actively present son life process author refers intergenerational change finally case study helps mitigate dearth positive research african american fathers challenging deficit based research narratives
comment elson ferguson areas agreement noted terms need thoroughly scientifically document boundary conditions violent video games impact players however argued contrast elson ferguson violent media generally violent video games specifically increase likelihood aggressive behavior desensitization violence linked increases aggressive attitudes beliefs also argued research findings demonstrating violent video game effects must considered terms known impacts types media human thoughts behavior well documented psychological processes empirically demonstrated underlie acquisition types social behavior aggression end evidence provided types media advertising shown clearly impact human psychology psychological mechanisms potentially underlie media violence effects discussed noted clearly evident reasons violent video games impact thoughts behavior less media subject different psychological processes research evidence considered contexts concluded mentioned impacts violent media exposure human thought behavior including violent digital games demonstrated two levels proof balance probabilities beyond reasonable doubt
recent years desired bandwidth class amplifier widened using sampling frequencies low possible example expected application power amplifier vibration generator bandwidth kept khz within load impedance infinity similar omega paper shown demand class amplifier attained adof approximate degree freedom digital controller khz switching sampling frequencies controller implemented fpga shown experiments demand attained enough
article deals ability fractional modeling describe bounded diffusion behavior encountered modern thin film nanoparticles lithium battery electrodes indeed diffusion impedance batteries behaves half order integrator characterized warburg impedance high frequencies becomes classical integrator described capacitor low frequencies transition two behaviors depends particles geometry three considered paper planar cylindrical spherical ones fractional representation proposed gray box model able perfectly fit low high frequency diffusive impedance behaviors optimizing frequency response transition identification results provided using frequential simulation data considering three electrochemical diffusion models based particles geometry furthermore knowing geometry allows estimate diffusion ionic resistance time constant using relationships linking physical parameters structural fractional model parameters finally simulations using randles impedance models including charge transfer impedance external resistance demonstrate interest fractional modeling order identify properly charge transfer impedance also diffusion physical parameters whatever particles geometry elsevier rights reserved
study presents system based passively controlled leading trailing edge flaps designed suppress wind induced instabilities flutter torsional divergence utility approach demonstrated three dimensional bridge model particular emphasis placed early stages deck erection process bridge particularly vulnerable flutter flaps activated deck movements though passive phase compensating mechanisms comprising springs dampers inerters demonstrated optimised compensator parameters optimum hinge locations result substantially improved deck aerodynamic performance particular importance given ensuring controlled system good closed loop robustness properties words controlled system high tolerance parameter variations uncertainties system dynamics practical use nonlinear optimisation algorithm bridge aeroelastic model includes flap dynamics necessitates use reduced order models novel model reduction procedure based retention dominant poles introduced aeroelastic modelling framework multimodal interactions observed various erection stages conclusions drawn regard contributions various modes vibration aeroelastic instabilities main advantage approach lies passive system simplicity ability simultaneously increase flutter torsional divergence boundaries humber bridge chosen study example numerical simulations elsevier ltd rights reserved
osi open system interconnection iec model published two sided point point communication tcp protocol became widely accepted standard building block distributed applications osi standards states transport layer reliable transmission data segments points network including segmentation acknowledgement multiplexing year network reliable named top fallacy distributed computing peter deutsch colleagues understanding two conflicting descriptions seemingly object lasting myth distributed parallel processing investigating myth lens extreme scale computing revealed impossible implement reliable communications face crashes either sender receiver every point point communication channel impossibility theory exposed two unacceptable risks arbitrary data loss increasing probability data losses infrastructure expands size therefore direct use point point protocols distributed parallel applications cause notorious scalability dilemma top fallacy allegation distributed computing supported theory practice scalability dilemma responsible growing planned unplanned downtimes existing infrastructures also responsible reported data service losses mission critical applications makes large scale computation reproducibility increasingly difficult growing instability also linked inability quantify parallel application scalability paper reports statistic multiplexed computing smc paradigm designed solving scalability reproducibility problems preliminary computational results reported support proposed solution
transaction costs occur good service transferred across technologically separable interface include costs drafting negotiating enforcing agreement also costs governance bonding secure commitments complex high risk environment construction project questionable decisions made planning design phase disagreements conflicts disputes change orders claims occur construction phase problems contribute increase transaction costs transaction costs pre contract phase project different transaction costs post contract phase however consensus standard definition transaction costs construction projects study detailed literature review focusing transaction costs construction project management presented factors affect transaction costs identified categorized headings owner contractor roles transaction project management efficiency characteristics transaction environment
coming rest night side comet churyumov gerasimenko rolis camera board rosetta philae lander acquired five images surface lander four aid led illumination different colors images confirm philae perched sloped surface local horizon visible one corner image beyond see coma spent full day surface philae commanded lift rotate final sixth led image acquired change perspective allowed construct shape model surface distance foreground much larger nominal caused stray light rather directly reflected led light dominate image signal complicating analysis images show lumpy surface roughness apparently fractal nature appearance completely different first landing site characterized centimeter meter sized debris mottola recognize neither particles pores image resolution per pixel large color variations absent surface modal brightness distribution interpreted terms degree consolidation hypothesis support experimental evidence propose surface lander consist smooth cracked plates unconsolidated edges similar terrain seen civa images elsevier inc rights reserved
background satiety sweet craving strongly influenced secretion gastrointestinal hormones dependent dietary factors okinawan based nordic breakfast moderately low carbohydrate content high fat protein contents shown increased postprandial satiety along improved endocrine metabolic profile primary aim study estimate degree satiety sweet cravings gastrointestinal symptoms dietary intervention correlate subjective estimates anthropometric metabolic hormonal parameters health related quality life hrqol secondary aim correlate visual analogue scale irritable bowel syndrome vas ibs hrqol questionnaire rand methods thirty type diabetes patients given okinawan based nordic diet weeks blood sampling anthropometric measuring completion questionnaires satiety sweet cravings vas ibs rand performed baseline weeks dietary intervention weeks follow results satiety increased dietary intervention sweet craving decreased without correlations parameters changes persisted throughout study period follow satiety inversely correlated gip social functioning sweet craving correlated leptin levels weight bmi waist circumference vitality less abdominal pain psychological improvement seen dietary intervention gastrointestinal symptom reduction afterwards correlations parameters conclusions diet moderately low carbohydrate content high fiber fat protein contents renders increased satiety reduced sweet craving independently anthropometric hormonal metabolic psychological factors improved psychological well hrqol preceeds reports decreased gastrointestinal symptoms
diabetic ketoacidosis mild hyperglycemia major complication sodium glucose cotransporter inhibitors although use approved patients type diabetes mellitus drug often prescribed hope optimizing metabolic control report years old female hypothyroidism type diabetes consulting vomiting abdominal pain patient used canagliflozin two previous months laboratory showed blood glucose severe metabolic acidosis ketonemia patient successfully treated intensive care unit
objective patients irritable bowel syndrome ibs asia show distinctive differences western world gastrointestinal endocrine cells appear play important role pathophysiology ibs present study aimed studying density chromogranin cga cells large intestine thai norwegian ibs patients methods thirty thai ibs patients control subjects norwegian ibs patients control subjects included standard colonoscopy performed patients controls biopsy samples taken colon rectum biopsy samples stained hematoxylin eosin immunostained cga density cga cells determined computerized image analysis results colon rectum cga cell densities far higher ibs healthy thai subjects norwegians colonic cga cell density lower norwegian ibs patients controls differ thai ibs patients controls rectum cga cell densities thai norwegian patients differ controls conclusions higher densities cga cells thai subjects norwegians may explained higher exposure infections childhood development broad immune tolerance differences intestinal microbiota differing diet habits normal cga cell density thai ibs patients contrast norwegians may due differences pathophysiology
article devoted suitable choice input parameters efficient running self developed code used damage detection code prepared office excel vba used non destructive vibration based method primary aim code determine change bending stiffness using model updating method aim paper determine effect input data bending stiffness calculations code applied numerical model steel bar steel bar simply supported beam span time calculations precision identification investigated values time consumption depend input values desired limit accepted error length step every iteration data experimental model analysed model made wooden plaster boards calculations done accordance suitable input data parametric study
compact low noise inexpensive preamplifier circuit designed fabricated optimally readout common cathode channel sic schottky photodiode array use ultraviolet experiments readout uses operational amplifier capacitor feedback loop parallel low leakage switch channels circuit configuration allows reiterative sample integrate reset sampling technique given remove johnson noise enabling femtoampere level readout noise performance commercial shelf acquisition electronics used digitize preamplifier analog signals data logging acquisition electronics different integration circuit allows bandwidth gain independently adjusted using readout photoresponse measurements across array spectral wavelengths made establish array pixels external quantum efficiency current responsivity noise equivalent power published elsevier
piezoelectric materials long used sensors actuators however use electrical generators less established materials capable converting mechanical vibration energy electrical energy developing piezoelectric generators challenging poor source characteristics high voltage low current high impedance relatively low power output paper presents theoretical analysis design piezoelectric power generation low frequency applications design method obtained piezoelectric equivalent circuit analysis internal stress important considerations designing generators explored including parameter estimation load matching efficiency energy conversion energy storage prototype hand shaking piezoelectric generator proposed used drive wireless switch device driving voltage experimental results show average electrical power hand shaking piezoelectric generator approximated
discrete fluid power systems featuring transmission lines inherently include pressure oscillations experimental verification discrete fluid power power take system wave energy converters shown cylinder pressure oscillate force shifts performed article investigates cylinder pressure oscillations may reduced shaping valve opening trajectory without need closed loop pressure feedback furthermore energy costs reducing pressure oscillations investigated
background postoperative atrial arrhythmias aas common lung transplantation studies mixed regarding impact outcomes therefore performed systematic review meta analysis determine whether aas lung transplantation impede postoperative recovery methods medline embase cinahl cochrane register searched identify studies comparing outcomes adult patients undergoing lung transplantation experienced postoperative aas immediate postoperative period without postoperative aas primary outcome perioperative mortality secondary outcomes length stay los postoperative complications mid term years mortality results nine studies including patients included analysis group postoperative aas patients postoperative aas significantly higher perioperative mortality longer hospital los days frequent requirement tracheostomy higher mid term mortality conclusions aas lung transplantation frequent associated significantly higher mortality longer hospital los requirement tracheostomy given impact recovery prophylactic strategies aas need developed
operant conditioning chamber cornerstone animal behavioral research operant boxes used assess learning motivational behavior animals particularly food drug reinforcers however commercial operant chambers cost several thousands dollars constructed rodent operant bucket robucket inexpensive easily assembled open source operant chamber based arduino microcontroller platform used train mice respond sucrose solution liquid reinforcers apparatus contains two nose pokes drinking well solenoid controlled liquid delivery system robucket run fixed ratio progressive ratio training schedules programmed run complicated behavioral paradigms additional features motion sensing video tracking added operant chamber array widely available arduino compatible sensors design files programming code open source available online others use
advent recommendation itu rec color space ultra high definition television uhdtv development gamut mapping algorithm wide standard gamuts greatly needed wide gamut uhdtv production particularly assumption simultaneous live uhdtv high definition television hdtv broadcast scenarios real time gamut mapping uhdtv hdtv vital designing algorithm requires careful consideration shape size significantly different gamuts paper set requirements gamut mapping uhdtv hdtv propose hue preserved gamut mapping algorithm mapping paths designed cie cielab color space modifications hue prediction based subjective experimental results constant perceived hue prevent excessive chroma reduction lightness gamut colors changed design process mathematical expressions proposed gamut mapping algorithm provided addition demonstrate improvements image quality
objective recent studies suggested autoimmune diseases immune activation play part pathogenesis different neurodevelopmental disorders study investigated association personal history family history autoimmune disease risk developing attention deficit hyperactivity disorder adhd method cohort formed singletons born denmark resulting study population individuals followed information autoimmune diseases obtained danish national hospital register individuals adhd identified danish national hospital register danish psychiatric central register results total children diagnosed adhd study period autoimmune disease individual associated increased risk adhd incidence rate ratio primary analyses associated maternal autoimmune disease adhd offspring incidence rate ratio whereas paternal history autoimmune diseases significantly associated adhd offspring exploratory analyses increased risk adhd observed children family history thyrotoxicosis type diabetes autoimmune hepatitis psoriasis ankylosing spondylitis conclusion personal history maternal history autoimmune disease associated increased risk adhd previously reported association type diabetes adhd confirmed addition specific parental autoimmune diseases associated adhd offspring
complications following anterior cruciate ligament acl injury reconstruction include chronic dysfunction second acl injury posttraumatic osteoarthritis may interrelated stem inability fully restore native acl integrity function loss acl sensory input following injury may significantly contribute joint dysfunction developed novel preclinical animal model assess contributions acl sensory afferents knee joint function health hypothesized acl sensory denervation would manifest knee joint dysfunction development early purpose bred adult research dogs dogs knees underwent arthroscopic surgery create three treatment groups partial acl tear acl denervated whole joint denervated neurotoxin injected directly acl joint space used induce sensory denervation sham procedures done contralateral knees intervention dogs participated regimented exercise program gait analysis clinically relevant functional assessments performed week animals humanely euthanatized arthroscopic gross histologic assessments acl partial tear group demonstrated greatest overall knee dysfunction clinical measures function revealed significant difference acl partial tear acl denervated group significant reduction limb loading experienced acl partial tear group compared controls observed acl pathology severity scores acl partial tear acl denervated groups results study indicate acl sensory loss may contribute joint dysfunction subsequent changes investigation development model important improve clinical therapies optimize patient outcomes following acl injury
background real time reverse transcription polymerase chain reaction pcr routinely used detect viral infections brazil mandatory use nucleic acid tests detect hepatitis virus hcv hepatitis virus human immunodeficiency virus blood banks immunological window use internal control necessary differentiate true negative results consequent failure step nucleic acid test objectives aim study construction virus modified particles based bacteriophage used diagnosis rna viruses methods genome cloned petb plasmid generating petb like particles produced synthesis rna genome rna polymerase particles used non competitive assays rna virus diagnostics addition competitive control hcv diagnosis developed cloning mutated hcv sequence replicase gene petb produces non propagating particle utility like particles evaluated one step format multiplex real time pcr hcv detection findings demonstrated competitive non competitive could successfully used monitor hcv amplification performance including extraction reverse transcription amplification detection steps without compromising detection samples low target concentrations conclusion like particles generated strategy proved useful rna virus diagnosis advantage produced low cost protocol attractive feature system allows construction multicontrol insertion sequences one pathogen increasing applicability diagnosing different rna viruses
recent research overdistribution principle implies episodic memory infected conjunction illusions instances item presented single context list falsely remembered presented multiple contexts list list robust conjunction illusions detected source monitoring designs conjunctive probes bagpipe presented list list added traditional nonconjunctive probes bagpipe presented list experiment levels illusions comparable would expected basis results prior overdistribution experiments experiments conjunction illusions neither eliminated reduced manipulation effects illusions products subjective differences retrieved memory support also conjunction illusions sometimes rose level conjunction fallacies certain conditions subjects thought items likely occurred presentation contexts single context impossible two general approaches explaining overdistribution representational accounts retrieval accounts considered
last decades geotextiles progressively incorporated geotechnical applications especially field coastal engineering geotextile materials often act separator filter layer rocks laid subgrade beneath versatile material gradually substituted traditional granular materials ease installation consistent quality labour cost efficiency however geotextiles often suffer damage installation due high dynamic bulk loading rock placement degrade geotextiles mechanical strength properties considered paper include impact resistance retained strength geotextiles general greater impact energy applied geotextiles greater potential damage results highlight inadequacy using index derived values indicator determine geotextile performance site test results shows geotextiles staple fibre continuous filament better mechanical properties outperform lower mechanical strength materials toughest product cbr index value shows inferior impact resistance compared product least cbr strength given impact energy test results also indicated reduction strength materials much greater compared materials subjected impact energy elsevier ltd rights reserved
meshes deployed wide range application processes transmission compression simplification watermarking inevitably introduce geometric distortions may alter visual quality rendered data hence efficient model based perceptual metrics operating geometry meshes compared recently introduced control predict visual artifacts however since models ultimately visualized screens seems legitimate use images models snapshots different viewpoints evaluate visual fidelity work investigate use image metrics assess visual quality models goal conduct wide ranging study involving several metrics rendering algorithms lighting conditions pooling algorithms well several mean opinion score databases collected data allow determine best set parameters use image based quality assessment approach compare approach best performing model based metrics determine use case respectively adapted conclude exploring several applications illustrate benefits image based quality assessment
propose framework developing comprehensive biophysical model could predict simulate realistic longitudinal mris patients alzheimer disease framework includes three major building blocks atrophy generation brain deformation iii realistic mri generation within framework paper focuses detailed implementation brain deformation block carefully designed biomechanics based tissue loss model given baseline brain mri model yields deformation field imposing desired atrophy voxel brain parenchyma allowing csf expand required globally compensate locally prescribed volume loss approach inspired biomechanical principles involves system equations similar stokes equations fluid mechanics presence non zero mass source term use model simulate longitudinal mris prescribing complex patterns atrophy present experiments provide insight role different biomechanical parameters model model allows simulating images exactly tissue atrophy different underlying deformation fields image explore influence different spatial distributions atrophy image appearance measurements atrophy reported various global local atrophy estimation algorithms also present pipeline allows evaluating atrophy estimation algorithms simulating longitudinal mris large number real subject mris complex subject specific atrophy patterns proposed framework could help understand implications different model assumptions regularization choices spatial priors detection measurement brain atrophy longitudinal brain mris elsevier inc rights reserved
advances geographic information interactive two three dimensional map visualization accompanied proliferation mobile devices location data tremendously benefited development geo educational applications demonstrate limo web based programming environment centered around operations interactive geographical maps location oriented data operations synthetic objects move maps limo materializes low cost open ended environment integrates interactive maps spatial data open streetmap unique advantage limo relates programming concepts interactive geographical maps location data limo offers environment students learn program providing easy program library map spatial operations high quality interactive map graphics example programs introduce users writing programs limo environment
increasing availability multicore systems led greater focus design implementation languages writing parallel programs languages support various abstractions parallelism fork join async finish futures may seem similar abstractions lead different semantics language design implementation decisions significantly impact performance end user applications paper consider question whether would possible unify various paradigms parallel computing end propose calculus called dag calculus encode fork join async finish futures possibly others describe dag calculus semantics establish translations aforementioned paradigms dag calculus translations establish dag calculus sufficiently powerful encoding programs written prevailing paradigms parallelism present concurrent algorithms data structures realizing dag calculus multicore hardware prove proposed techniques consistent semantics finally present implementation calculus evaluate empirically comparing performance highly optimized code prior work results show calculus expressive competes well sometimes outperforms state art
present continuous variable quantum key distribution qkd scheme based quantum teleportation coherent states yields raw secret key made discrete variables alice bob protocol preserves efficient detection schemes current technology single photon detection techniques time efficient error correction privacy amplification schemes due binary modulation key show certain type incoherent attack secure almost value transmittance optical line used alice share entangled two mode squeezed states bob loss limitation characteristic beam splitting attacks present cvqkd protocol works deterministically postselection needed efficient direct reconciliation techniques reverse reconciliation order generate secure key beyond loss case incoherent attack level
deal data structures algorithms bundles binary images represented raster data paper bundle images called multiple layer image purpose introduce algorithms rotation objects included multiple layer binary images addition provide rotation translation binary image time
objective test phenotypic plasticity framework using polygenic approach prospective depression cohort primary care attendees without histories severe childhood abuse methods depressive symptoms assessed baseline annually years post baseline using primary care evaluation mental disorders patient health questionnaire phq among adult primary care attendees twelve polymorphisms nine genes genotyped polygenic phenotypic plasticity allelic load pal calculated linear mixed models assessed differences depressive symptom severity year follow period pal history severe childhood abuse results higher pal conferred greater depressive symptom severity among history severe childhood abuse conferred significantly lower symptom severity among without history importantly interaction withstood adjustments important covariates antidepressant use comorbid anxiety stable years observation conclusions aligned phenotypic plasticity framework depressive symptom severity dependent interaction pal history severe childhood abuse better worse manner measures polygenic phenotypic plasticity may serve trait marker sensitivity negative potentially positive environmental influences
use laser assisted machining lam improve various aspects machinability high strength materials laser used intense heat source decrease strength materials machined prior cut modifying certain parameters power position beam cutting parameters machinability microstructure surface layer often modified beat input laser study undertaken determine optimum cutting parameters quantify influence fatigue strength depending type microstructure created two metals bearing steel aisi aeronautical titanium alloy tialv bearing steel significant increase fatigue resistance observed due transformation surface layer martensite titanium alloy slight reduction fatigue strength found case microstructure residual stress state surface layer less beneficial surface roughness also measured significant variation observed different laser powers material
paper explores perceptions regarding family paid employment expressed university students chile based analysis quantitative data maule region southern chile argue increasing unpredictability labor markets eroded role paid employment historically lynchpin individual particularly men life project altering expectations work family life likewise changes gender roles shaped youngsters ideals family life seems case especially women strongly affirm economic independence personal projects departing traditional family views conclude young people demanding new balance life understood mainly personal family time work also strong affirmation individual project including demand greater gender equality although still level projected visions future findings signal changes way relation work family traditionally organized bringing new challenges public policy
objective purpose study investigate association migraine headache concussion athletes design case control observational study setting university associated combined sports neurology orthopedic sports medicine clinic participants total male female athletes aged years including concussion cases orthopedic controls included study interventions participants completed one page questionnaire recorded age sex reason visit concussion injury concussion history self immediate family member migraine headache history main outcome measures odds previous history migraine headache compared concussion group versus orthopedic controls results controlling group differences age sex significant positive association concussion group status history migraine headache adjusted odds ratio confidence interval however including previous concussion history statistical model relationship failed reach significance adjusted conclusions results suggest association migraine headache concussion athletes cause effect nature relationship determined migraine headache considered modifying factor caring concussed athletes
construction manager general contractor cmgc project delivery rapidly implemented deliver full gamut highway projects across united states one issue must resolved public transportation agency advertise cmgc contract whether include price selection scheme much weight price component carry versus evaluation criteria paper discusses results research topic based analysis experience public transportation agencies cmgc projects states paper finds learning curve mapped change price factor weight time agency gains experience cmgc details finding via case study utah department transportation cmgc program paper concludes non price factors cmgc contractor approach preconstruction phase important price factors carry greater weight evaluation plan also finds weight accorded price factors decreases agency gains cmgc experience finally recommends agencies trying cmgc first time focus selection scheme factors reflect given contractor ability collaborate owner designer preconstruction phases project rather obtaining lowest price
research criteria alzheimer disease recommend use biomarkers diagnosis whether biomarkers improve diagnosis clinical routine systematically assessed aim evaluate evidence use medial temporal lobe atrophy mta biomarker alzheimer disease mild cognitive impairment stage routine clinical practice adapted version phase oncology framework biomarker development literature review visual assessment mta hippocampal volumetry conducted biomarkers addressed parallel reviews ample evidence available phase rationale use phase discriminative ability diseased control subjects phase early detection ability partly achieved evidence derived research cohorts clinical populations short follow validation clinical mild cognitive impairment cohorts required phase practical feasibility addressed visual rating mta rest phase phase yet addressed elsevier inc rights reserved
growing electronic design automation eda industry automated analog circuit design feasible solution demand exploit span nonlinear circuit behaviors devices circuits flexibility optimize numerous competing continuous valued performance specifications order meet desired specifications state art eda tools employed depend upon efficient effective optimization techniques suffice cost designing complex analog systems paper hybrid metaheuristic based pso presented design one prominent design specifications gains two stage cmos operational amplifier circuit simple operational transconductance amplifier circuit subject variety design conditions constraints convergence pso improved advancing local solutions using achieve quality global optimum solution experimental results compared standard optimization techniques show performance proposed hybrid metaheuristic terms optimization quality robustness
important part aggregation simulation model building optimization simulation model paper concept model element correlation introduced reduction algorithm model based genetic rough set algorithm designed algorithm design implementation process described paper correctness algorithm described last applicability algorithm proved example
objective cysteinyl leukotrienes cyslts lipid mediators implicated pathogenesis allergic rhinitis pharmacological studies cyslts indicate two classes receptors cyslt cyslt exist cyslt high affinity ltd receptor lower affinity ltc cyslt antagonist currently used treat asthma allergic rhinitis cyslt binds ltc ltd equal affinity gpr also called gpr previously described oxoglutarate receptor oxgr recently emerged potential novel receptor lte purpose study determine expression localization gpr protein human nasal mucosa methods human turbinates obtained turbinectomy patients nasal obstruction refractory medical therapy gpr protein expression evaluated western blotting specific cells expressing gpr protein identified immunostaining using commercial anti gpr oxgr monoclonal antibody results kda band detected western blots human nasal samples using anti gpr monoclonal antibody find differences gpr protein levels allergic non allergic nasal mucosa immunohistochemical studies revealed antigpr monoclonal antibody mainly labeled vascular smooth muscle cells nasal mucosa conclusion immunohistochemical results suggest gpr may play roles vascular response functional studies necessary clarify biological significance gpr receptor nasal vasculature elsevier ireland ltd rights reserved
primary aldosteronism associated increased urinary calcium excretion osteoporosis prevalence studied long term effect hyperaldosterone fracture risk possible risk mitigation via treatments comparing patients essential hypertension counterparts extracted propensity score match used longitudinal population database taiwan national health insurance used validated algorithm identify patients diagnosed sample included patients including patients aldosterone producing adenoma apa methods assessing excessive fracture risk included multivariable cox regression competing risk regression incidence rate fracture site per person years per person years apa contrast incidence rate fracture site per person years controls per person years controls apa mineralocorticoid receptor antagonist mra treatment might associated higher risk osteoporotic fracture whole female cohort subdistribution hazard ratio shr well female apa patients shr fracture site mra treatment also associated higher risk shr whole female cohort female apa patients tightly associated higher risk bone fracture even case competing risk death controlled particularly female patients treated mra confronted significantly higher risk bone fracture controls american society bone mineral research
pilot study effectiveness feasibility parent child interaction therapy pcit decreasing disruptive behavior evaluated young children autism spectrum disorder asd pcit behaviorally based play therapy targets parent child relationship live coaching play interactions implementation consistent discipline techniques following average sessions disruptive behavior measured multiple indices significantly decreased congruently parents increased positive parental following skills decreased negative parental leading skills across course treatment addition parents reported increased levels child functional communication prosocial behavior high levels parent acceptability intervention also noted effect sizes medium large across measured dependent variables including parent report behavioral observations implications clinical use pcit within asd population future research controlled outcome studies discussed
continuum manipulator compliance enables operation delicate environments challenging actuation control approaches case catheter ablation atrial fibrillation compliance continuum backbone lends inherent safety device inherent safety frustrates attempts precise accurate fast control limiting continuum devices simple static positioning tasks paper develops interleaved continuum rigid manipulation hysteretic nonlinearities encountered tendon actuated continuum manipulators compensated discrete rigid joints located continuum sections rigid joints introduce actuation redundancy interleaved controller may use avoid continuum nonlinearities dynamic excitations prefer particular configurations may improve task accuracy permit greater end effector forces avoid environment obstacles two experimental systems explore potential joints increase manipulator dexterous workspace correct actuation nonlinearities enhance manipulator performance experiments also expose important design control observations apparent general robotic continuum literature
background knowledge software database solution supports large volumes biological time series sensor data efficiently enables data visualization analysis real time existing solutions managing data typically use unstructured file systems relational databases systems designed provide instantaneous response user queries furthermore support rapid data analysis visualization enable interactive experiments large scale experiments behaviour slows research discovery discourages widespread sharing reuse data could otherwise inform critical decisions timely manner encourage effective collaboration groups results paper present sensordb web based virtual laboratory manage large volumes biological time series sensor data supporting rapid data queries real time user interaction sensordb sensor agnostic uses web based state art cloud storage technologies efficiently gather analyse visualize data conclusions collaboration data sharing different agencies groups thereby facilitated
previous study tensile tests ligament fascicle swine hind limbs revealed tangent modulus stress strain curve ligaments stiffness higher fascicles since ligament composite fascicles ground substance whose stiffness almost negligible finding contrary current notion strength materials composite never stronger constituent elements answer puzzling question hypothesized fascicles stiffness uniform along longitudinal axis weaker portions mainly elongated tensile tests stiffness underestimated tensile testing ligament weaker portions fascicles reinforced stronger portions adjoining fascicles study confirm hypothesis hold performed tensile tests fascicles thereby finding fascicles elongate uniformly next developed continuous elastic model taking account fascicle kinematic non uniformity along longitudinal direction mechanical interaction fascicles ground substance simulation results demonstrated inverse characteristics ligaments fascicles furthermore results helped understand ligament failure mechanism ipem published elsevier ltd rights reserved
research examined affective cognitive responses culture fusion specific type culture mixing features blending different cultures parts thereof new entity influenced individual differences need closure nfc two studies showed individuals high low nfc felt less favorable toward culture fusion affective response abstract level society structure models study concrete level food stimuli study addition high nfc individuals tended assign culturally fused stimuli one discrete culture rather acknowledging culturally hybrid cognitive response furthermore mediation analyses showed relationships nfc responses toward culture fusion mediated right wing authoritarianism findings interpreted terms threat epistemic security needs posed culture fusion
worldwide economic impact dementia estimated billion usd without discovery cure effective interventions delay disease progression dementia annual global economic impact expected surpass trillion usd early alzheimer disease leading cause dementia accounting cases toxic accumulation amyloid beta beta either overproduction clearance failure thought underlying mechanism neuronal cell death characteristic though amyloid hypothesis increasingly challenged recent years compelling alternative hypothesis points chronic neuroinflammation common root late life degenerative diseases including apolipoprotein apoe genotype strongest genetic risk factor apoe epsilon proinflammatory individuals genotype accumulate beta high risk developing almost half patients atleast one epsilon allele recent studies suggest bidirectional relationship exists sleep pathology sleep may play important role beta clearance getting good quality sleep poor quality sleep might reduce risk associated neuroinflammation epsilon allele taken together findings particularly important given sleep disruptions commonly associated increased burden disrupted sleep poses caregivers current review aims identify individuals high risk dementia may benefit sleep interventions explore role poor sleep quality plays exacerbating type dementia examine science sleep interventions date provide road map pursuit comprehensive sleep interventions specifically targeted promote cognitive function delay progression dementia
experimental study conducted single cylinder forced air cooled hydrogen fuelled spark ignition generator set converted gasoline fuelled generator set rated power kva rpm study carried various compression ratios base spark timings degrees top dead centre btdc exhaust gas recirculation egr volume furthermore experimental tests conducted engine varied start gas injection various compression ratios order find backfire limiting start injection bfl soi results indicated engine operation higher compression ratio improved brake thermal efficiency reduced backfire occurrence residual gas fraction decreased increased compression ratio however nox emission increased increased compression ratio order reduce nox emission source level engine operated retarded spark timings different egr percentage relative nox emission decreased spark time retarding degrees btdc maximum brake torque mbt whereas decreased volume egr delay gas injection could reduce chance backfire occurrence bfl soi decreased increased compression ratio notable point emerged study hydrogen fuelled spark ignition engine spark time retarding suitable strategy nox emission reduction whereas egr optimum level better strategy could reduce nox emission compared base hydrogen engine without egr copyright hydrogen energy publications llc published elsevier ltd rights reserved
trend towards electrical drivers rather mechanical drivers offshore installation led implementation large electrical systems power generation due offshore environment constraints weight footprint limitations installation remains operated voltage lower leads specific constraints electrical network design paper provides overview implementation pyrotechnic current limiting devices design stage precommissioning commissioning operation case study also developed based fault event occurred fpso floating production storage offloading leading severe damage consequences operation conditions pyrotechnic current limiting devices operated correctly fault occurred damage production losses due causes highlighted
composite data sets measured different objects usually affected random errors may also influenced systematic genuine differences objects experimental conditions individual measurements forming data set quantitative approximately normally distributed correlation coefficient often used compare data sets however relations data sets obvious matrix pairwise correlations since numerical value correlation coefficient lowered random systematic differences data sets work presents multidimensional scaling analysis pairwise correlation coefficients places data sets unit sphere within low dimensional space position given values defined karplus diederichs science radial direction systematic differences one angular directions dimensionality reduction used classification purposes also derive data set relations continuous scale projecting arrangement data sets onto subspace spanned systematic differences surface unit sphere allows irrespective random error levels identification clusters closely related data sets method gains power increasing numbers data sets illustrated example low signal noise ratio image processing application macromolecular crystallography shown approach completely general thus widely applicable
stress adolescence risk factor schizophrenia medial prefrontal cortex mpfc dysfunction proposed interfere stress control increasing susceptibility stress evaluated impact different stressful events adolescence restraint stress footshock combination behaviors correlated schizophrenia rats adults adulthood animals tested anxiety responses elevated plus maze cognitive function novel object recognition test dopamine system responsivity locomotor response amphetamine neuron activity ventral tegmental area vta using vivo electrophysiology adolescent stressors impaired weight gain induced anxiety like responses adults also disrupted cognitive function interestingly combination induced hyper responsivity indicated augmented locomotor response amphetamine increased number spontaneously active neurons confined lateral vta additionally prelimbic mpfc lesions triggered hyper responsivity animals exposed alone adolescence results consistent previous studies showing long lasting changes induced stressful events adolescence impact system activity however seems depend intense multiple stressors data also suggest plpfc dysfunction increases vulnerability stress terms changes system hence stress adolescence could precipitating factor transition schizophrenia stress control vulnerable period may circumvent changes prevent emergence psychosis
paper reports investigation effect fabric substrates coating materials electrical mechanical performance printed antennas inductively coupled antennas printed fabrics using silver ink assure printability protection printing structure configured consisting surface coating conductive printing protective coating order simulate realistic situation three fabric substrates denim broadcloth single jersey selected woven knit fabrics everyday wear three coating materials acrylic polyurethane silicone chosen conventional conformal coating materials printed circuit boards experimental results verified fabric substrates selected fit specific end use application since shown antenna performance significantly affected silicone coating suggested support antenna performance since gave least impairment fabrics mechanical performance
objective purpose systematic review evaluate effectiveness multimodal care management soft tissue injuries lower extremity methods systematically searched medline embase psycinfo cinahl cochrane central register controlled trials random pairs independent reviewers screened studies relevance critically appraised eligible studies using scottish intercollegiate guidelines network criteria included studies low risk bias best evidence synthesis results screened articles six studies low risk bias addressed following plantar heel pain adductor related groin pain patellofemoral pain evidence suggests multimodal care management persistent plantar heel pain may include mobilization stretching exercise intensive clinic based group exercise program strengthening stretching balance agility effective multimodal care management adductor related groin pain male athletes inconclusive evidence support use multimodal care management persistent patellofemoral pain search identify low risk bias studies examining multimodal care management soft tissue injuries lower extremity conclusion multimodal program care management persistent plantar heel pain may include mobilization stretching exercise multimodal care adductor related groin pain recommended based current evidence inconclusive evidence support use multimodal care management persistent patellofemoral pain
dynamic data structures software applications shown large impact system performance paper explore energy saving opportunities interface based dynamic data structures results suggest savings opportunities exist collection propose prototype architecture creating adaptive green data structures applying machine learning tools build model predicting energy efficient data structures based dynamic workload neural network model classify energy efficient data structures based features number elements frequency operations interface set bag semantics fold cross validation result show average accuracy predictions gram model accurately predict energy efficient data structure sequence simulated real world programs average accuracy using bigram predictor greenc prototype demonstrates green data structure implemented simple decision making technique data structure efficiently adapt energy efficiency low overhead actual medians greenc potential energy savings two test computers range elsevier inc rights reserved
proper handling samples analyzed mass spectrometry guarantee excellent results greater depth analysis working quantitative proteomics critical trying assess non traditional sources ear wax saliva vitreous humor aqueous humor tears nipple aspirate fluid breast milk colostrum cervical vaginal fluid nasal secretions bronco alveolar lavage fluid stools intend provide investigator relevant aspects quantitative proteomics recognize recent clinical research work conducted atypical samples analyzed quantitative proteomics reference recent different approaches used non traditional sources allows compare new strategies development novel experimental models hand references help contribute significantly understanding proportions proteins different proteomes clinical interest may lead potential advances emerging field precision medicine
background intracerebroventricular injection beta amyloid beta mice allows investigation acute effects cognitive function cellular pathology aim investigation characterize time course beta induced cognitive behavioural changes detect potential molecular mechanisms methods cannulas implanted lateral cerebral ventricle days surgery mice injected beta phosphate buffered saline pbs starting pbs days injection evaluated cognitive behavioural performance using modified hole board test mhbt determined tumour necrosis factor alpha tnf alpha caspase western blotting days data analysed using general linear modelling kruskall wallis mann whitney test results beta induced decline cognitive performance represented increased total number wrong choices testing period day behavioural parameters comparable mice treated beta pbs difference regarding tnf alpha levels groups compared day caspase levels increased day conclusions application beta lateral ventricle mice associated cognitive impairment declarative memory mhbt interference caused altered behaviour therefore represents valid model acute beta mediated neurotoxic effects although exact mechanisms remain unclear changes levels caspase suggest apoptosis important factor development cognitive dysfunction elsevier rights
background autoimmune involvement pathogenesis asthma chronic obstructive pulmonary disease copd proposed autoantibodies hallmark autoimmunity study aimed compare autoantibody profiles asthma copd relationship auto antibodies features diseases methods recruited asthma patients copd patients prospective study six autoantibody types evaluated antinuclear antibody anti cytoplasmic antibodies rheumatoid factor anti cyclic citrullinated peptide antibody myeloperoxidase anti neutrophil cytoplasmic autoantibody mpoanca proteinase anca clinical data also recorded concurrently results antinuclear antibody titre presented asthma copd eosinophil counts blood negative predictors antinuclear antibody asthma conversely eosinophil counts blood immunoglobulin levels positively associated rheumatoid factor asthma copd relationship antinuclear antibody rheumatoid factor disease severity conclusions possible asthma tends involve autoimmunity associated antinuclear antibody frequently copd asthma robust factor antinuclear antibody positivity antinuclear antibody rheumatoid factor associated eosinophilic responses work biomarlcers disease severity copyright japanese society allergology production hosting elsevier
studies vivo vitro suggested mechanism underlying alzheimer disease neuropathogenesis initiated interaction cellular prion protein prpc amyloid beta oligomers beta prpc beta complex activates fyn kinase turn hyperphosphorylates tau tau resulting synaptic dysfunction neuronal loss cognitive deficits transgenic mice lacking prpc accumulate beta show normal survival loss spatial learning memory suggesting prpc functions downstream beta production upstream intracellular toxicity within neurons since traumatic brain injury tbi linked chronic traumatic encephalopathy tauopathies examined whether similar mechanistic pathways responsible tbi pathophysiologies using transgenic mice expressing different levels prpc studies investigated influence necessity prpc biomarker total tau tau tau gfap levels brain blood measured biochemically following severe tbi form severe closed head injury schi found following schi increasing levels tau tau brain associated prpc expression levels similar relationship prpc expression tau levels following schi found blood absence significant tau changes effect seen gfap increased within following schi progressively decreased day time point regardless prpc expression levels changes levels biomarkers independent gender enhanced expanded quantitation brain biomarkers correlative studies using immunohisochemistry also demonstrate tbi induced calpain hyperactivation required generation tau relationship demonstrated presence absence prpc levels tau cognitive dysfunction studies suggest prpc important mediating tbi related pathology
antibacterial resistance increasing globally recognized major public health threat antibacterial stewardship coordinated effort improve appropriate use antibiotics aim decrease selective pressure multidrug resistant organisms order preserve utility antibacterial agents article describes activities antibacterial resistance leadership group arlg area antibacterial stewardship date arlg focused intensely development rapid diagnostic tests coupled educational institutional initiatives enable robust stewardship needed address current crisis antibacterial resistance addition exploring effectiveness stewardship techniques community hospitals arlg also developed strategy trials assess feasibility reducing antibacterial usage preserving patient outcome
selectins guide traffic activated cells blood stream mediating tethering rolling onto inflamed endothelium way acting beacons help navigate sites inflammation present comprehensive analysis selectin ligands expressed activated human cells identified several novel glycoproteins function selectin ligands specifically compared role selectin glycoprotein ligand psgl known selectin ligands ligand previously characterized selectin ligand activated human cells showed acts functional selectin ligand expressed cells moreover protein carries binding epitope identifying hematopoietic cell selectin ligand hcell furthermore knocking ligands individually together primary activated human cells demonstrated hcell cooperates psgl major selectin ligand additionally demonstrated relevance findings chronic autoimmune disease showing hcell psgl cells isolated psoriasis patients bind selectin
introduction rotavirus leading cause acute gastroenteritis children although clinical complaints associated rotavirus generally gastrointestinal including vomiting diarrhea data suggest also cause symptoms extend beyond gastrointestinal tract case presentations report three pediatric cases rotavirus infection one accompanied encephalopathy two elevated hepatic transaminase activity patients admitted sami ulus maternity children health diseases training research hospital ankara turkey presented patients aspartate aminotransferase ast alanine aminotransferase alt levels date highest reported levels associated rotavirus infections suggest rotavirus cause severe hepatic transaminase elevation conclusions report aimed increase awareness occurrence extra intestinal systemic manifestations rotavirus infection although cases may rare still suggest rotavirus systemic viral infection
schizophrenia highly heritable disorder diverse mental somatic symptoms molecular mechanisms leading genes disease pathology schizophrenia remain largely unknown genome wide association studies gwass shown common single nucleotide polymorphisms associated specific diseases enriched recognition sequences transcription factors regulate physiological processes relevant disease used bottom approach tracked developmental trajectory embryology physiological processes behavior recognized transcription factor homeobox nkx possesses properties particular interest schizophrenia nkx selectively expressed prenatal development adulthood brain thyroid gland parathyroid gland lungs skin enteric ganglia key functions interface brain endocrine immune system developing brain nkx expressing progenitor cells differentiate distinct subclasses forebrain gabaergic cholinergic neurons astrocytes oligodendrocytes transcription factor highly expressed mature limbic circuits related context dependent goal directed patterns behavior social interaction reproduction fear responses responses light homeostatic processes essential development mature function thyroid gland respiratory system involved calcium metabolism immune responses nkx interacts number genes identified susceptibility genes schizophrenia suggest nkx may lie core several dose dependent pathways dysregulated schizophrenia correlate symptoms seen schizophrenia temporal spatial activities nkx order highlight promising future research areas
work presents project teaching innovation subject technology manufacturing developed last five years objective stimulate students training self evaluation system based learning tools agreement guidelines european higher education area ehea system includes methodology perform series evaluations theoretical practical knowledge allows student self learning data obtained proposed system analyzed effect student results discussed evolution time student grades involvement satisfaction project influence final score presented
histone methylation plays important roles regulating chromatin dynamics transcription eukaryotes implication histone modifications fungal pathogenesis however beginning emerge report identification functional analysis putative jmjc domain containing histone demethylase magnaporthe oryzae bioinformatics analysis identified seven genes encode putative histone demethylases containing jmjc domain deletion one gene mojmj belonging jared group resulted defects vegetative growth asexual reproduction appressorium formation well invasive growth fungus western blot analysis showed global hkme level increased deletion mutant compared wild type strain indicating histone demethylase activity mojmj introduction mojmj gene delta mojmjrestored defects pre penetration developments including appressorium formation indicating importance histone demethylation mojmj infection specific morphogenesis however defects penetration invasive growth complemented discuss incomplete complementation detail work mojmj provides insights hkme mediated regulation infection specific development plant pathogenic fungus
several acute chronic inflammatory diseases driven accumulation activated leukocytes due enhanced chemokine expression addition specific protein coupled receptor dependent signaling chemokine glycosaminoglycan gag interactions important chemokine activity vivo therefore gag chemokine interaction explored target inhibition chemokine activity demonstrated cxcl binds high affinity gags competed active chemokines gag binding thereby inhibited cxcl monosodium urate msu crystal induced neutrophil migration joints evaluate affinity specificity cooh terminal part cxcl toward different gags detail chemically synthesized several cooh terminal cxcl peptides including shorter cxcl compared cxcl cxcl showed equally high affinity heparin heparan sulfate lower affinity binding chondroitin sulfate cellular gags correspondingly peptides competed equal efficiency cxcl binding heparin cellular gags addition differences anti inflammatory activity peptides detected vivo cxcl induced neutrophil migration peritoneal cavity knee joint inhibited similar potency intravenous intraperitoneal injection cxcl cxcl cxcl contrast neutrophil extravasation msu crystal induced gout model multiple chemoattractants induced affected cxcl could explained lower affinity cxcl abundant gag joints reduced competition gag binding cxcl abundant elr cxc chemokine gout model mechanistically showed intravital microscopy fluorescent cxcl coats vessel wall vivo cxcl inhibits cxcl induced adhesion neutrophils vessel wall murine cremaster muscle model thus affinity specificity chemokines peptides different gags presence specific gags different tissues determine whether competition occur summary cxcl peptides inhibited neutrophil migration vivo interference gag interactions several animal models shortening cxcl cooh terminus limited gag binding spectrum
paper reports evaluation properties novel structure known oasis designed coventry university enhancement commercially available geotextiles incorporated permeable pavement system pps impact hydraulic behaviour pps analysed study infiltration rate throughout pps time required reach steady state stage behaviour water within pps extreme rainfall intensities corresponding year return period rainfall duration min different parts world result indicated novel structure provides extra benefit incorporated ppss delaying peak flow rainfall event retaining storing great volumes water within structure additional benefits especially important extreme rainfall events
aim authors proposed retrospectively assess incidence ankle sprain relevant risk factors footballers playing teams province parma professional season methods sixty six football clubs province parma associated italian football federation contacted athlete involved filled questionnaire results fifty three athletes suffered case ankle sprain professional season amateurs semi professionals professionals highlighted majority cases ankle sprain caused contact game significant relations distortion period year number weekly training sessions type footwear worn characteristics pitch presence past traumas discussion level sports activity appears important factor injury related risks resumption professional activity august october related higher incidence traumatisms intense training session seems protect traumas incidence sprain appear related role player conclusion different causes ankle sprain footballers reduce incidence traumas advisable apply adequate preventive measures basis frequent risk factors
paper presents distributed approach optimal power flow opf electrical network suitable application future smart grid scenario access resource control decentralized non convex opf problem solved augmented lagrangian method similar widely known admm algorithm key distinction penalty parameters constantly increased weak assumption local solver reliability required always ensure convergence certificate convergence local optimum available case bounded penalty parameters moderate sized networks nodes even presence severe partition network approach guarantees performance close optimum appreciably fast convergence speed generality approach makes applicable convex non convex distributed optimization problem networked form comparison literature mostly focused convex sdp approximations chosen approach guarantees adherence reference problem also requires smaller local computational complexity effort
bace major therapeutic target prevention treatment alzheimer disease developing inhibitors selectively target bace favor proteases especially cathepsin catd presented significant challenges investigate conformational dynamics protonation states bace catd using continuous constant molecular dynamics replica exchange sampling protocol despite similar structure bace catd exhibit markedly different active site dynamics bace displays dependent flap dynamics controls substrate accessibility catd flap relatively rigid remains open range interestingly although protease hydrolyzes peptide bonds protonation states catalytic dyads different within active range acidic basic components bace catalytic dyad clear either aspartic acid catd catalytic dyad could play role acid base finally investigate binding inhibitor developed eli lilly bace catd surprisingly enzyme active range forms stronger salt bridge catalytic dyad catd bace might explain retinal toxicity inhibitor related target inhibition catd work highlights complexity challenge structure based drug design receptor ligand binding induces protonation state change protein inhibitor wiley periodicals inc
maanshan bridge yangtze river china new long span suspension bridge double main spans closed streamlined cross section single box deck flutter performance bridge investigated via wind tunnel test full bridge aeroelastic model geometric scale test conducted smooth simulated boundary layer wind fields various combinations wind yaw inclination angles unique interesting flutter mode transition behavior observed smooth flow wind speed approaches flutter threshold model oscillation first antisymmetric torsional mode transfers alternate torsional oscillation double spans transfers oscillation first symmetric torsional mode violent oscillation occurs mechanism phenomenon unknown may numerical method simulate date one possible reason flutter mode transition nonlinear aerodynamic self excited force acting middle pylon dragged full aeroelastic model soft type flutter inference internal resonance occurred energy transforms two spans modes time american society civil engineers
focusing leak points petrochemical industries paper discusses key factors equipment temperature gas pressure diffusion rate petrochemical industries data sensors petrochemical industries need timely operated time sensitivity hard achieve associated information sensors located production sites end propose three level framework based improved back propagation tlbp real time data streams processed according arriving time input layer time neuron optimizing solution introduced learning process deal redundant invalid neurons thereby accelerating response speed learning reducing prediction time finally propose improved mechanism multidimensional learning factor lower learning error higher convergence rate meanwhile fulfill distributed prediction leak points see one three level data processing unit logic machine multiple operators using assignment scheduling general scheduling problem split common subproblem every operator system overhead reduced processed data obtain relative location diffusion radius leak points well area leak points simulation results show tlbp performs better related algorithms differentmetrics besides adaptability tlbp verified leak points prediction petrochemical equipment processed data
development polycystic ovary syndrome exact pathophysiological mechanism still unclear environmental genetic factors likely play role exposition teratogenic effects prenatal development lead chronic diseases postnatal period finding confirms common familial aggregation well literature search conducted january articles dealing genetic epigenetic factors polycystic ovary syndrome review discuss current understanding genetic basis clinical presentation disease
seismic response wusong bridge analyzed though response spectrum method time history method adopting midas civil analysis results show longitudinal displacement main girder much larger longitudinal seismic input inhibiting device dampers used avoid impacting coupling longitudinal lateral seismic excitations seismic response moment shear force bottom main tower much larger contrary seismic response main beam main cable calculated longitudinal vertical seismic excitations coupling furthermore artificial seismic wave fitting standard response spectrum generated conduct time history analysis results much larger results response spectrum method
work suggests method systematically constructing software level environment model safety checking automotive operating systems introducing constraint specification language osek csl osek csl designed specify usage constraints automotive operating systems using pre defined set constraint types identified international standard osek vdx constraint specified osek csl interpreted either regular language context free language checked finite automaton pushdown automaton set usage constraints used systematically classify universal usage model osek vdx based operating systems generate test sequences varying degrees constraint satisfaction using ltl model checking pre defined constraint patterns full support automation test engineers choose degree constraint satisfaction generate test cases using combinatorial intersections selected constraints cover corner cases classified constraints series experiments open source automotive operating system show approach finds safety issues effectively conventional specification based testing scenario based testing conformance testing
latest developments database technologies becomes easier store medical records hospital patients first day admission previously possible intensive care units icu modern medical information systems record patient events relational databases every second knowledge mining huge volumes medical data beneficial caregivers patients given set electronic patient records system effectively assigns disease labels facilitate medical database management also benefit researchers pathologists paper proposed framework achieve goal medical chart note data patient used extract distinctive features encode patient features apply bag words encoding method chart note data also propose model takes account global information local correlations diseases correlated diseases characterized graph structure embedded sparsity based framework algorithm captures disease relevance labeling disease codes rather making individual decision respect specific disease time global optimal values guaranteed proposed convex objective function extensive experiments conducted real world large scale icu database evaluation results demonstrate method improves multi label classification results successfully incorporating disease correlations
romosozumab romo humanized sclerostin antibody bone forming agent development treatment osteoporosis examine effects romo bone quality mature cynomolgus monkeys cynos treated months post ovariectomy ovx vehicle romo months romo months followed vehicle months serum bone formation markers increased romo first months corresponding increased cancellous endocortical periosteal bone formation rib iliac biopsies months dual energy ray absorptiometry dxa bone mineral density bmd increased lumbar spine proximal femur month corresponding significant increases bone strength lumbar vertebral bodies cancellous cores femur diaphysis neck bone mass remained positively correlated strength sites changes calculated material properties cortical sites bone quality measures also maintained group despite gradual loss accrued bone mass normal bone mineralization confirmed histomorphometry ash analyses radial diaphysis transient reversible reduction cortical bmd observed romo month despite relative improvements bone mineral content bmc high resolution pqct confirmed decline cortical bmd radial diaphysis metaphysis second set ovx cynos administered romo months radial diaphyseal strength maintained metaphyseal strength improved romo estimated finite element modeling decreased radial cortical bmd consequence increased intracortical remodeling increase cortical porosity romo resulted marked improvements bone mass architecture bone strength maintaining bone quality ovx cynos supporting bone efficacy safety profile american society bone mineral research
introduction vulvar vaginal atrophy vva affects two thirds postmenopausal women symptomatic women receive prescription therapy aim evaluate postmenopausal women perceptions vva treatment options symptoms women empower survey methods rose research firm conducted internet survey female consumers provided lightspeed global market insite women least years age reported symptoms vva residing united states recruited main outcome measures survey results compiled analyzed women treatment subgroups results respondents median age years range currently used prescribed vva therapies local estrogen therapies oral selective estrogen receptor modulators whereas former users prescribed vva therapies used counter treatments never used treatment many women aware vva medical condition never users never discussed symptoms health care professional hcp main reason women discuss symptoms hcp believed vva natural part aging something live women spoke hcp symptoms initiated discussion preferred sources information written material hcp office questionnaires fill seeing hcp negative attributes hormonal products perceived risk systemic absorption messiness local creams need reuse applicator overall hcps recommended vaginal estrogen therapy oral hormone therapies women using vaginal estrogen therapy less half women adhered complied posology women extremely satisfied efficacy conclusion women empower survey showed vva continues recognized treated condition despite recent educational initiatives disconnect education communication information hcps menopausal patients remains prevalent copyright authors published elsevier inc behalf international society sexual medicine
paper presents results studying spatial distribution maximum monthly rainfall within kingdom saudi arabia ksa using geographic information systems gis isohyetal maps constructed based long historical rainfall depth data rain gauges processing data using different interpolation methods conversion grid raster six interpolation methods used kriging spline natural neighbor inverse distance weighting idw modified shepard triangulation linear interpolation tin estimations rainfall rain gauges compared observed measurements controls method resulted minimum residuals minimum standard deviation case idw selected study percentage residuals within found idw modified shepard tin natural neighbor spline kriging identifying potential water harvesting sites depends many factors watershed area topography morphology rainfall results study used primary selection water harvesting sites based rainfall important factor
background epidemiological clinical studies demonstrated comorbidity migraine affective disorders however unclear whether chronic migraine lead affective disorders animals methods classical chronic migraine rat model repeated dura mater inflammatory soup infusion used evaluate depression anxiety behaviour via weight sucrose preference test open field test elevated plus maze test results found sucrose preference locomotor rearing behaviours inner zoon distance percent open arm entries percent serotonin dopamine levels prefrontal cortex decreased significantly group compared control group administration low dose amitriptyline ameliorated deficits however differences weight inner zone time percent open arm time percent control groups results used create new depression anxiety scales comprehensively assess evaluate degree affective disorders rats chronic migraine animals showed depression anxiety like behaviors conclusions chronic migraine rats present depression anxiety like behaviors new scales created expected use future studies find potential mechanism affective disorders comorbidity
fundamental study single bubbles rising confined geometries motivated aeration membrane bioreactors parameters channel depth bubble size superimposed liquid velocity rheology liquid newtonian non newtonian varied flow field close bubble negative wake non newtonian liquid discussed data presentation introduced allowing statistical analysis cumulative distribution functions velocity magnitude vorticity strain shear stress extracted flow fields parameter combination except channel depth almost analyzed properties increased increasing bubble size superimposed liquid velocity influence rheology results visible especially shear stress
increased galectin expression currently showed associated poor prognosis hematological malignancies acute myeloid leukemia diffuse large cell lymphoma however little known clinical significance galectin patients acute promyelocytic leukemia apl investigated concentration serum galectin characterized relationship galectin outcome patients apl higher galectin levels detected patients apl compared healthy controls higher galectin levels closely associated older ages medical history psoriasis coagulopathy expression compared patients lower galectin levels higher galectin levels significant shorter overall survival relapse free survival multivariate analysis showed serum galectin independent unfavorable factor relapse free survival patients apl treated trans retinoic acid arsenic trioxide based frontline therapy clinical impact galectin investigated patients apl
background current studies report mixed results health status health behaviors diagnosis cancer aim study investigate potential differences lifestyle factors among cancer survivors cancer free individuals prospective cohort study conducted united states methods using data prostate lung colorectal ovarian plco trial cancer survivors identified compared participants without cancer evaluate differences body mass index bmi smoking nsaid use physical activity results cancer survivors compared cancer free significantly less likely engage physical activity odds ratio compared obese baseline cancer survivors likely normal bmi follow compared cancer free cancer survivors less likely report regular aspirin use compared cancer free population current smokers cancer survivors likely former smokers follow compared cancer free conclusion upon stratification baseline health markers cancer survivors practice healthier lifestyle habits smoking cessation maintenance healthy weight however cancer survivors less likely physically active compared cancer free individuals regardless baseline practices implications cancer survivors cancer survivors reported poor health status behaviors baseline cancer diagnosis may encourage practice healthier lifestyle behaviors
determination accurate plasma horizontal position plasma discharge control system based feedback essential transport safe position near set point design feedback controller usually based primitive modeling plasma using plasma circuits linearized model proportional integral derivative based controllers model power supply vertical coil system values poles analyzed step feedback response overall system tokamak corresponding bode diagrams two cases without plasma resistance eddy currents distribution although experimental validation plasma model also overall system behavior important exercise results predicted simulation give good insight system
paper describes teaching strategies lean project construction management training course organized civil engineering program pontifical catholic university peru school science engineering intention inspiring scholars practitioners explains training course objectives content well principles tools techniques practices lean construction philosophy among others also includes incorporation management system tools techniques complement paper also describes lectures workshops simulations made well feedback obtained students collaborative work routines among others success training course reflected opportunities improvement identified editing publishing made possible feedback collected participants authors published elsevier ltd
report successful treatment hepatitis virus hcv transmitted nucleic acid testing nat negative donor three hcv negative recipients two renal transplants one liver renal recipients underwent standard deceased donor renal transplantation immediate graft function liver recipient underwent standard orthotopic liver transplantation recovered uneventfully donor year old woman terminal serum creatinine high risk bloodborne pathogens based upon history sexual contact hcv infected male partner recipient year old man history end stage renal disease systemic lupus erythematosus recipient year old woman history end stage renal disease caused hypertension insulin dependent diabetes recipient year old man acute liver failure acetaminophen ingestion recipients became hcv polymerase chain reaction positive post transplant follow kidney recipients treated ledipasvir sofosbuvir combination therapy weeks without side effects rejection episodes recipient treated ledipasvir sofosbuvir combination ribavirin weeks without side effects patients achieved sustained viral response weeks considered cured hcv kidney recipients maintained good allograft function serum creatinine respectively renal recipients maintained normal liver function post treatment develop evidence fibrosis liver recipient liver function tests returned normal without incident case report provides evidence successful treatment donor derived hcv transplant recipients
low bone mineral density bmd osteoporosis become public health problem found non hispanic white black asian adults extremely low education personal income likely lower bmd relationship gender specific findings valuable guide bone health interventions evidence limited regarding relationship socioeconomic status ses bone mineral density bmd minority populations usa well relationship ses bmd men study explored examined relationship ses bmd race ethnicity gender data louisiana osteoporosis study los examined including data non hispanic whites non hispanic blacks non hispanic asians general linear models used estimate relationship ses bmd total hip lumbar spine stratified race ethnicity gender adjustments made physiological behavioral factors adjusting covariates men education levels high school graduate experienced relatively low hip bmd counterparts college graduate education addition women reporting personal annual income relatively low hip spine bmd counterparts higher income level establishing conclusive positive negative association bmd ses proved difficult however individuals extreme ses disadvantage vulnerable relatively low bmd study population efforts promote bone health may benefit focusing men low education levels women low individual income
underutilised crops represent important component southern africa agro biodiversity potential contribute region post development discourse reviewed potential underutilised crops respect contribute topical challenges food nutrition security human health well climate change adaptation environment employment creation poor rural communities fact underutilised crops product generations landrace agriculture supports idea resilient adapted needs farmers marginal agricultural environments addition underutilised crops also seen offering economic advantages due uniqueness suitability environments grown low input requirements certain cases underutilised crops associated specific gender roles women seen particularly significant production evidence also suggests inclusion underutilised crops cropping systems contributes dietary diversity improved nutrition context post agenda potential underutilised crops generate income address food security status subset biodiversity links number sustainable development goals sdgs addressing social economic environmental issues
paper use electricity consumption model electric vehicular flow xiao huang tang mod phys lett study effects road conditions electricity consumption electric vehicular flow evolutions shock rarefaction wave small perturbation numerical results indicate road conditions negative influences electricity consumption evolutions shock rarefaction wave electricity consumption increases road conditions become better positive impacts electricity consumption evolution small perturbation traffic flow unstable electricity consumption produces oscillation amplitude decreases road conditions become better
angina pectoris defined substernal chest pain pressure discomfort typically exacerbated exertion emotional stress lasts greater seconds relieved rest nitroglycerin approximately million people united states angina cases diagnosed per year several studies show angina predictor major adverse cardiac events addition angina serious morbidity impedes quality life treated united states pharmacologic therapy angina includes blockers nitrates calcium channel blockers late sodium current blocker ranolazine countries additional pharmacologic agents include trimetazidine ivabradine nicorandil fasudil others revascularization indicated certain high risk individuals also shown improve angina however even revascularization substantial percentage patients return recurrent continued angina requiring newer better therapies treatment refractory angina amenable usual pharmacologic therapies revascularization procedures includes enhanced external counterpulsation transmyocardial revascularization stem cell therapy angina continues significant cause morbidity therapy geared treating risk factors atherosclerotic disease improving survival also aimed eliminating reducing occurrence angina improving ability patients active
background purpose thick corpus callosum tcc associated grave outcome fetuses clinical presentation older children seems markedly different methods corpus callosum defined thick based observations impressions reviewed cases children diagnosed tcc based brain magnetic resonance imaging mri studies pertinent clinical data children collected ccs measured results brain mri images children initially considered showing tcc initial imaging reviewed experienced neuroradiologist confirmed diagnosis children neurofibromatosis epilepsy macrocephaly capillary malformation mcm syndrome autistic spectrum disorder chiari malformation increased head circumference specific neurologic disorder could defined seven children measured thickness children comparable published literature adults conclusions tcc rare brain malformation found neuropathologies apparently diverse pathognomonic mechanisms mcm necessarily associated life threatening conditions instead relatively benign finding different nature reported fetuses
full software radio receiver supposed receive signals wide band within range ghz linearity constraints strong non idealities complex system non idealities generate undesired signals interferers leading degradation reception counteracted compensation paper proposes mixed system wide band linearization consisting analog spectral sensor sasp digital signal processor dsp analog compensation signal generator high level simulation results vhdl ams language exhibits rejection continuous wave interferers
previously identified microdeletion del maternally imprinted peg domain cattle results loss paternal mimt expression causes late term abortion stillbirth mutation inherited sire semilethal progeny mortality precisely delineate deletion describe comparative analyses fetuses carrying deletion wild type siblings global dna methylation analysis cotyledon tissue revealed greater global cpg methylation fetuses deletion gene expression microarray analyses identified increased npsra ilrn nos ilr zdhhc smoc expression fetuses carrying deletion decreased grid plg igf expression involvement npsra ilrn nos ilr genes suggests form restriction related blood supply perhaps hypoxemia may play role pathological mechanism also imprinted genes known play role mammalian prenatal development specifically igf dlk mest ast peg apeg showed differential expression striking difference abundant abnormal expression neuropeptide receptor npsr gene placental cotyledon tissue mimt del fetuses similarity proportion semilethal mortality rate suggests abnormal npsr expression may linked death survival mimt del fetuses npsr expressed two isoforms isoform detected mimt del cotyledons npsra normally expressed placenta role stillbirth phenomenon yet elucidated may provide useful prognostic indicator
context combinatorial testing strategies lately received lot attention result diverse applications simple form combinatorial strategy reduce several input parameters configurations system small set based interaction combination practice input configurations software systems subjected constraints especially case highly configurable systems implement feature within strategy many difficulties arise construction many combinatorial interaction testing strategies nowadays support constraints objective paper presents new strategy construct combinatorial interaction test suites presence constraints method design algorithms provided detail overcome multi judgement criteria optimal solution multi objective particle swarm optimisation multithreading used strategy associated algorithms evaluated extensively using different benchmarks comparisons results results promising evaluation results showed efficiency performance algorithm strategy benchmarking results also showed strategy generate constrained test suites efficiently compared state art strategies conclusion proposed strategy form new way constructing constrained combinatorial interaction test suites strategy form new effective base future implementations elsevier rights reserved
definitive treatment paediatric femoral diaphyseal fractures remains controversial modalities treatment vary mostly according age fracture pattern site lesser impact current evidence reflective variation evidence cited american academy orthopedic surgeons level authors present review date evidence relating treatment fractures age group attempt clarify current trends produced algorithm decision making based experience tertiary referral level major trauma centre
address intermittency solar energy system due unforeseen weather conditions improve dispachability requirement thermal energy storage tes system becoming increasingly inevitable single tank packed bed thermocline tes system potential provide effective solution comprehensive one dimensional non thermal equilibrium model considered solved using method characteristics investigate energy storage single tank packed bed thermocline storage system thermal characteristics including temperature profiles discharge effectiveness different commercially available heat transfer fluids htfs explored analyzed tank size height diameter considered capacity present study effect porosity discharge effectiveness storage tank different htfs investigated porosity epsilon varied found discharge effectiveness consistently drops epsilon value increases htfs two dimensional numerical simulation also carried explore transient temperature distribution inside tank different htfs porosity observed operation time tank increases filler material eventually loses heat adjacent fluid attains equilibrium thermocline moves faster rate solar salt hitec due higher viscosity elsevier ltd rights reserved
objectives present study compare polymorphisms beta muc genes patients burning mouth syndrome bms controls investigate relationships polymorphisms clinical characteristics bms patients forty female bms patients gender age matched controls included genomic dna extracted saliva samples single nucleotide polymorphisms beta variation number tandem repeat vntr polymorphism muc analyzed relationships genotypic polymorphism data clinical characteristics bms patients also analyzed significant differences genotypes beta muc groups significant differences symptom duration intensity bms patients according beta muc genotypes allele beta showed associations psychometry results bms patients paranoid ideation global severity index positive symptom total genotypic polymorphisms beta muc vntr direct associations development bms however allele beta may increase risk bms increasing psychological asthenia genotypic polymorphisms beta may increase risk development bms increasing psychological asthenia
determine current status psoriatic arthritis conducted retrospective survey sending questionnaires newly visited psoriatic arthritis patients accounted confidence interval newly visited psoriasis patients april march institutes additionally questionnaires detailed patients information returned institutes response rate patients psoriatic arthritis identified male predominance mean onset age psoriatic arthritis years mean onset age cutaneous psoriasis years lower arthritis years mean duration patients developed psoriasis prior arthritis years patients preceded arthritis years according moll wright criteria polyarthritis type common followed distal interphalangeal type oligoarthritis type peripheral joint pain back pain lumbago neck pain enthesitis dactylitis observed respectively biologics used psoriatic arthritis patients used disease modifying antirheumatic drugs conclusion ratio psoriatic arthritis japan increasing nearly new psoriasis patients psoriatic arthritis study shows current status psoriatic arthritis japan including several unexpected findings male predominance longer duration onset cutaneous psoriasis arthritis dominance polyarthritis
background depressed anxious patients often combine complementary alternative medicine cam therapies conventional pharmacotherapy self treat symptoms benefits risks combination strategies fully evaluated paper evaluates risk benefit profile cam augmentation antidepressants affective conditions methods pubmed searched available clinical reports published english december data evaluated based graded levels evidence efficacy safety results generally evidence base significantly larger depression anxiety disorder unipolar depression level evidence adjunctive sleep deprivation free easy wanderer plus fewp level exercise yoga light therapy omega fatty acids adenosylmethionine tryptophan bipolar depression level evidence adjunctive omega level level fewp anxiety conditions exercise augmentation level support generalized anxiety disorder panic disorder though mostly well tolerated therapies recommended third line interventions due quality available evidence limitations overall literature limited studies often methodological weaknesses little information long term use potential drug cam interactions many cam studies published english conclusions several cam therapies show evidence benefit augmentation depressive disorders evidence largely lacking anxiety disorders general dearth adequate safety tolerability data encourages caution clinical use elsevier rights reserved
electron content ionosphere important quantity indicates overall ionization measured means propagation effects radio signals penetrate ionosphere europe relevant investigations started launch first artificial satellites soon necessity arose organize international cooperation regional well global geographical distribution ionization parameters important knowledge meaningful geophysical interpretation ionization parameters despite fact international scientific unions committees existed proven usefulness potential private initiatives taken organize cooperation field research based transionospheric propagation effects three international groups joined together form beacon satellite group aof cospar thestill exists working group ursi international union radio science contribution tries summarize european perspective special emphasis long standing cooperation istituto ricerca sulle onde elettromagnetiche iroe firenze institut fur meteorologie und geophysik university graz examples given important results
objective synthesize descriptions periarticular findings metacarpophalangeal mcp wrist joints different types arthritis normal state imaged high resolution peripheral quantitative computed tomography pqct assemble literature reporting ability pqct detect findings relative imaging modalities collate results reproducibility image interpretation methods systematic literature review performed using terms pqct mcp wrist joints using medical literature databases conference abstracts study describing predefined pathology findings comparison another radiographic technique measure reproducibility included limitation disease state results identified studies meeting inclusion criteria articles identified search reported pathology findings including erosions bone microarchitecture bone mineral density variables joint space evaluation osteophyte characterization seventeen studies compared pqct findings either plain radiography ultrasound magnetic resonance imaging microcomputed tomography pqct high sensitivity erosion detection twenty four studies included assessment reproducibility good excellent metrics highlighting critical importance positioning assessing joint space variables conclusion despite high sensitivity erosion detection good reproducibility research required determine pqct applied enhance understanding periarticular bone changes variety arthritis conditions
paper presents systematic development steady state small signal models interleaved dual boost converter operating continuous current mode models derived employing well known signal flow graph method signal flow graph approach provides means directly translate switching converter equivalent graphic model complete behaviour converter easily studied steady state performance small signal characteristic transfer functions derived using mason gain formula bode plots audiosusceptibility input impedance output impedance control output transfer functions determined illustrated using matlab different values load resistances duty ratios small signal frequency responses obtained signal flow graph method validated pspice simulator results validate signal flow graph modelling equations sample steady state experimental results provided copyright john wiley sons ltd
underlying mechanism allergic rhinitis involves ige antibodies attaching allergen causing release inflammatory chemicals histamine mast cells cytokines important process many data suggest systemic shift intensely type dominated immune responses non allergic individuals conversely type dominated responses allergic individuals upon natural exposure grass pollen however studies found chemokine motif ligand cxcl interferon ifn gamma induced protein cxcl monokine induced ifn gamma mig concentrations elevated nasal lavages allergic patients suggesting chemokines may play role chronic allergic inflammation several studies also evaluated effect different immune modulating drugs allergic rhinitis showing local peripheral increase ifn gamma associated reduction symptoms studies needed clarify role helper chemokines pathogenesis allergic rhinitis evaluate role biomarkers disease response treatments
system identification offshore floating platforms usually performed testing small scale models wave tanks controlled conditions still water free decay tests regular irregular wave loading represented however approach may result constraints model dimensions testing time costs experimental activity reasons intermediate scale field modelling offshore floating structures may become interesting well cost effective alternative near future clearly since open sea controlled environment traditional system identification may become challenging less precise paper new approach based frequency domain decomposition fdd method operational modal analysis proposed validated numerical simulations ansys aqwa simple spar type structure results obtained match well numerical predictions showing new approach opportunely coupled traditional wave tanks techniques proves promising perform field site identification model structures
objective assess frequency characteristics oculographic findings usefulness clinical test sensory integration balance ctsib evaluation balance patients psoriatic arthritis psa comparing test computerized dynamic posturography cdp study design series consecutive patients fulfilled moll wright criteria psa matched controls studied setting study performed otolaryngology division tertiary reference center intervention vestibular evaluation including ctsib followed cdp performed patients age sex ethnically frequency matched controls main outcome measure patterns ctsib cdp gold standard assessed compared patients sixty psa patients women matched controls results psa patients higher frequency abnormal oculocephalic response abnormal caloric test controls cases respectively benign paroxysmal positional vertigo bppv diagnosed two patients none controls significantly increased frequency abnormal ctsib test vestibular loss pattern patients compared controls observed significantly increased frequency abnormal cdp also observed psa patients versus controls ctsib yielded sensitivity specificity positive predictive value negative predictive value conclusions study indicates oculographic findings common psa ctsib useful assessing balance disorder screening routine clinical practice patients
hyperphosphorylated tau critical role tauopathies alzheimer disease frontotemporal dementia impairing neuronal function eventually leading neurodegeneration critical role tau supported studies transgenic mouse models express tau mutation found cases familial frontotemporal dementia accumulation hyperphosphorylated tau hippocampus causing reductions hippocampal long term potentiation impairments spatial learning memory however remained unexplored role hyperphosphorylated tau reducing neuronal excitability show two complementary tau transgenic mouse models hyperphosphorylated tau induces depolarized threshold action potential initiation reduces firing hippocampal neurons rescued suppression transgenic tau furthermore using mutagenesis primary hippocampal neuronal cultures reveal reduction neuronal excitability results relocation axon initial segment ais axon tau phosphorylation dependent manner also demonstrate effect microtubule dependent addition pharmacological stabilization found prevent structural functional deficits caused tau hyperphosphorylation finally demonstrate ais neurons tau transgenic mice axon correlates reduction excitability therefore propose reduction hippocampal excitability due tau mediated distal relocalization ais contributes hippocampal dysfunction observed tauopathies
polarization one basic properties electromagnetic waves valuable communication navigation radar detecting important control manipulate polarization states electromagnetic waves paper design fabricate measure broadband reflective metamaterial degrees polarization rotator double split ring resonator dsrr structure composed two layers dielectric metal plate ground explanation physical mechanism polarization rotator presented according anisotropy media theory anisotropic metamaterials cause phase amplitude difference two crossed polarization waves used manipulate polarization states incident waves anisotropic polarization rotator behaves different two orthogonal axes surface current distributions dsrr discussed analyse different characteristics structure along two orthogonal axes dsrr behaves dipole resonator couples electric component along one axes behaves resonance circuit couples electric component thus almost equal magnitude degrees phase difference generated two orthogonal electric components reflected waves polarization states reflected waves rotated degrees incident waves polarized degrees respect symmetric axis rotator retained incident waves circularly polarized simulation results show device work relative bandwidth ghz polarization conversion ratio larger polarization conversion ratio decrease incident angle increases high polarization conversion ratio obtained several frequencies cell prototype polarization rotator fabricated using printed circuit board method substrates experimental results agree well simulation polarization rotator simple geometry operating frequency bands compared previous designs provides route broadband polarization rotation application values polarization control design new antenna stealth technology
rainwater harvesting rwh essential establishment human settlements many dry regions world lacked suitable surface groundwater resources vast fraction south american dry chaco ecoregion still relies rwh support livestock production domestic industrial uses well result water capture storage infrastructure widely disseminated throughout region paper characterized typical rwh systems two contrastingly developed sub regions dry chaco ranging extensive ranching intensive beef dairy production central argentina western paraguay respectively sub region quantified rwh systems density spatial distribution associations landscape features furthermore illustrated daily dynamic water stock typical rwh system contributes assess capture storage efficiency found randomly distributed low sophisticated rwh systems prevailed central argentina clustered distributed high sophisticated ones common western paraguay rwh systems density ten times higher western paraguay units showing exponential association land cleared fraction proximity villages daily dynamic water stock rwh impoundment showed water harvest events exponentially associated precipitation magnitude events annual water losses explained infiltration evaporation fluxes respectively across sub regions rwh accounts less annual precipitation playing minor role regional water balance however local level affect several hydrological fluxes including onset groundwater recharge mitigation extreme runoff events elsevier ltd rights reserved
engine performance varies significantly due variations weather conditions different regions order optimize performance fuel consumption engines calibrated according weather conditions operate paper effects air conditions pressure temperature power fuel consumption engine modeled first comprehensive one dimensional model real engine constructed power validated experimental data actual engine next using model set experiments carried varying pressure temperature humidity incoming air engine speed measuring outputs power bsfc engine two mathematical models developed using mlp neural networks also regression technique estimate outputs terms inputs last estimation ability models shown set new experiments models could used engine calibration shift process near blind one one prior information significant role
external difference families edfs new type combinatorial designs originated cryptography paper constructions edfs presented using gauss sums several classes edfs related combinatorial designs obtained
several studies recently demonstrated volumes specific brain regions reduced children adolescents post traumatic stress disorder ptsd compared healthy controls study investigated potential association early traumatic experiences altered brain regions functions conducted systematic review scientific literature regarding functional magnetic resonance imaging meta analysis structural magnetic resonance imaging studies investigated cerebral region volumes pediatric patients ptsd searched articles psycinfo pubmed medline lilacs isi web knowledge databases data regarding amygdala hippocampus corpus callosum brain intracranial volumes fit inclusion criteria extracted combined meta analysis assessed differences groups meta analysis found reduced total corpus callosum areas reduced total cerebral intracranial volumes patients ptsd total hippocampus left right hippocampus gray matter volumes amygdala frontal lobe also reduced differences significant functional studies revealed differences brain region activation response stimuli post traumatic stress symptoms ptsd group results confirmed pediatric patients ptsd exhibited structural functional brain abnormalities abnormalities occurred different brain regions observed adults
recent research suggests glucocorticoids involved development addiction drugs abuse share role dopamine different signalling pathways transcription factors extracellular signal regulated kinases erk camp response element binding protein creb however relation completely elucidated report characterize role glucocorticoid mineralocorticoid receptor signalling turnover nacc opiate withdrawal induced tyrosine hydroxylase expression erk creb phosphorylation activation nucleus tractus solitarius nts role signalling assessed selective antagonist mifepristone antagonist spironolactone rats implanted two morphine placebo pellets six days later rats pretreated mifepristone spironolactone vehicle min naloxone turnover expression erk creb phosphorylation measured using hplc immunoblotting glucocorticoid receptor blockade attenuated erk creb phosphorylation expression induced morphine withdrawal contrast changes seen blockade finally blockade alter morphine withdrawal induced increase seen turnover metabolite production nacc results show erk creb phosphorylation also expression nts modulated signalling present results suggest therapeutic target improve aversive events associated opiate withdrawal
recent years graphene two dimensional closely packed honey comb carbon lattice attracting much attention field electrochemistry due intrinsic properties merits moreover nickel found extensive use preparation biosensors present study applied simple straightforward approach development nickel nanoparticle graphene sheet ninp modified glassy carbon electrode gce nonenzymatic biosensor applications nanocomposites ninp various concentrations nickel nanoparticles ninps synthesized situ chemical reduction procedure order develop ninp modified gce suspension ninp dispersed deionized water dripped gce surface dried room temperature nanocomposites characterized using scanning electron microscope sem ray diffraction xrd additionally sensing performance evaluated cyclic voltammetry results clearly demonstrated synthesized ninps diameters less well uniformly distributed surface graphene nanosheets graphene sheets characterization data also demonstrated nanocomposite film large surface area enhanced electron transfer rate compared nanoparticles due efficient electrical network ninps direct anchoring surface graphene furthermore sensivity reproducibility prepared electrode better nickel electrodes reported good analytical performance low cost simple fabrication procedure make novel electrode material promising development effective non enzymatic glucose sensor published elsevier ltd
background ultraviolet induced light eruptions ple commonest disease due photosensitivity prevalent globally clinically observed many patients presenting ple either already diagnosed thyroid function abnormality later course developed derangement thyroid function tests tft aim study study association light eruptions thyroid stimulating hormone values materials methods prospective observational study comprising subjects patients presenting dermatological outpatient department opd index medical college indore diagnosed polymorphic light eruptions included study taking informed consent tsh levels analysed observations systematically noted see frequently coexisted results thyroid stimulating hormone level tsh abnormal cases patients polymorphic light eruptions tsh increased individuals decreased cases conclusion study highlights need routinely assess thyroid function tests patients ple early detection subclinical hypothyroidism made suggest larger population based studies detailed thyroid profile evaluation performed establish causal association two
liquid biopsy using digital pcr dpcr widely used screening esr mutations since frequently identified hotspot however dpcr limited known mutations therefore aimed analyze utility next generation sequencing ngs discover novel esr mutations whole exon sequencing esr gene using ngs performed primary recurrent tumor samples plasma samples hormone receptor positive metastatic breast cancer patients functional analyses performed novel mutations detected identified mutations primary tumors six mutations five recurrent tumors including three types known mutations two novel mutations also identified seven mutations five plasma samples including three types known mutations one mutation reported cosmic database nine patients esr mutations treated aromatase inhibitors ais prior sampling mutations frequently detected patients received treatments metastatic setting among three novel mutations showed ligand independent activity three mutant proteins showed nuclear localization relation non genomic pathways although molecular mechanisms mutations remain unclear data suggest utility ngs liquid biopsy metastatic breast cancer patients potential identify novel esr mutations
water shortage karst mountainous areas difficult problem faced worldwide serious surface water leakage karst characteristic puzzled global scientists long time local climate hydrology play important roles water resources occurrence behaviour turn affects surface groundwater management objectives study follows conduct depth analysis major problems current utilisation surface water resources karst areas reveal differences surface hydrogeological structures grew formed control different lithological characters surface water occurrence conditions cyclical rules propose strategies development effective utilisation water resources series technologies karst surface water resource use basis karst hydrogeological features development law proposed technologies include gully section runoff confluence water harvesting technology surface karst spring directional diversion technology sunken geomorphology ecotype cistern design technology road rainwater harvesting effective utilisation technology effective comprehensive utilisation rooftop rainwater harvesting technology surface water resource optimal allocation technologies thus study offers research driven technological solutions ease water shortage facilitate modern agriculture regional economic development karst mountainous areas elsevier rights reserved
minimum energy control problem fractional positive electrical circuits formulated solved sufficient conditions existence solution problem established procedure solving problem proposed illustrated example fractional positive electrical circuit
study investigates major barriers development china green buildings ways overcome barriers survey statistical analysis interview find high incremental cost immature green technologies two major barriers comprehensive balanced development green buildings china analyzing main causes high incremental costs solutions choosing general preferred items different order enhancing incremental cost efficiency green technology proposed moreover show green technology applications still early stage china three strategies improving use green technologies development highly cost effective green technologies also proposed present study provides recommendations overcome barriers could facilitate rapid full scale development green buildings china
backgroundthe aim research paper determine incidence risk factors clinical outcome solid organ transplant sot recipients diagnosed treated cryptococcosis institution methodsretrospective analysis patients sot diagnosed treated cryptococcal infection occurring january december resultsof patients diagnosed cryptococcal infection sot recipients renal transplant accounted cases meningitis annual incidence infection risen significantly greater prevalent renal transplant recipients expected biochemical factors associated meningitis include lower glucose cerebrospinal fluid csf analysis median mmol csf white blood cell median csf protein median serum cryptococcal antigen titers higher meningitis cohort median clinically headache admission odds ratio prolonged length stay median days meningitis cohort significant conclusioncryptococcal infection sot recipients remains rare however marked increase cases since study reveals need increased vigilance potential emerging infectious disease furthermore highlights need ongoing research aid early diagnosis prognostication management screening cost effectiveness
genetic improvement used improve functional nonfunctional properties software paper propose new approach applies genetic programming based genetic improvement trade functional non functional properties existing software paper investigates possibilities opportunities improving non functional parameters execution time code size power consumption median functions implemented using comparator networks general impossible improve non functional parameters median function without accepting occasional errors results optimal implementations available order address issue proposed method providing suitable compromises accuracy execution time power consumption traditionally randomly generated set test vectors employed assess quality individuals demonstrated approach may produce biased solutions test vectors generated inappropriately order measure accuracy determining median value avoid bias propose formally analyze new quality metrics based positional error calculated using permutation principle introduced paper shown proposed method enables discovery solutions show significant improvement execution time power consumption size respect accurate median function keeping errors moderate level non functional properties discovered solutions estimated using data sets validated physical measurements physical microcontrollers benefits evolved implementations demonstrated two real world problems sensor data processing image processing concluded data processing software modules offer great opportunity genetic improvement results revealed even necessary determine median value exactly many cases helps reduce power consumption increase performance discovered implementations accurate well approximate median functions available functions download employed custom application http www fit vutbr research groups ehw median
objectives investigate possible relationships among oral mucosal epithelial muc expression salivary female gonadal hormones stress markers clinical characteristics patients burning mouth syndrome bms design thirty post menopausal female patients bms years included clinical psychological evaluations performed expression level oral mucosal epithelial muc analyzed levels cortisol dehydroepiandrosterone dhea beta estradiol progesterone chromogranin blood contamination determined unstimulated whole saliva uws stimulated whole saliva sws samples results salivary progesterone level significant positive correlations oral mucosal epithelial muc expression level salivary cortisol dhea levels salivary level beta estradiol showed significant positive correlations period symptom duration severity effects oral complaints daily life results psychological evaluations cortisol level uws cortisol dhea ratio uws sws negative correlations severity oral burning sensation significantly severity taste disturbance positive correlations results psychometry significantly conclusion dysregulated psychoendocrinological interactions might affect oral mucosal muc expression severity oral burning sensation post menopausal bms patients elsevier ltd rights reserved
aim study evaluate association gene polymorphisms interleukin interferon gamma ifn gamma genes susceptibility severity hepatitis virus hcv infection among egyptian patients interleukin ifn gamma genotypes determined chronic hcv patients healthy controls using restriction fragment length polymorphism rflp amplification refractory mutation system polymerase chain reaction arms pcr respectively polymorphism genotyping revealed frequency genotype significantly higher chronic hcv patients controls versus regarding polymorphism genotyping higher frequency genotype found chronic hcv patients compared controls versus ifn gamma genotyping showed genotype significantly higher chronic hcv participants controls versus higher frequency allele found cirrhotic patients compared noncirrhotic patients observations suggested ifn gamma polymorphisms strong association susceptibility hcv infection however significant association observed cytokines ifn gamma genotypes profile hcv liver cirrhosis risk studied population except high frequency ifn gamma allele cirrhotic patients
low level radio frequency llrf control system linear accelerator legnaro national laboratories lnl infn upgraded new digital radio frequency controller controller critical keep phase amplitude frequency stability field quarterwave resonator qwr cavities linear accelerator cavities work superconducting condition resonance frequency low beta cavities mhz medium high beta cavities resonate mhz controller control time eight different cavities signals picked cavities sampled adcs digitized signals fed field programmable gate array fpga implements control loop signals processed fpga phase quadrature modulated sent power amplifiers hence cavities main feature new control system digital control loop originates direct sampling antenna signal phase quadrature components obtained suitable choice undersampling frequency control field phase cavity based digital complex phase modulator cpm paper presents fpga firmware acquisition techniques performances new controller
image given measurable data projections important task reconstruct find image provides measured data tomographic problems frequently used theory applications image processing paper memetic algorithms investigated triangular grids reconstruction binary images using three six direction projections algorithm generates initial population using network flow algorithm two input projections reconstructed images evolve towards optimal solution close optimal solution using crossover operators guided mutation operators quality images improved using switching components compactness operator elsevier rights reserved
highbush blueberry vaccinium corymbosum calcifuge acid loving plant responds favorably mulching organic matter recently blueberry plantings northwestern united states grown mulch douglas fir sawdust additional nitrogen fertilizer applied compensate immobilized sawdust decomposition field trial established oct aurora oregon usa evaluate alternative mulches partial full replacement sawdust within certified organic system mulch treatments sawdust alone depth yard debris compost covered sawdust geotextile weed mat treatments applied planting comprised one component factorial trial included two cultivars duke liberty two bed configurations raised flat two fertilizer sources fish emulsion feather meal two fertilizer rates low high organic mulches reapplied weed mat replaced four growing seasons average cumulative yields first years fruit production plant sawdust plant compost sawdust plant weed mat treatment highest cumulative yield regardless mulch liberty fertilized either low high rate feather meal years planting soil compost sawdust sawdust weed mat soil remained optimum range blueberry treatment soil depth higher compost sawdust sawdust weed mat leaf nutrient concentrations including nonresponsive mulch treatments overall study demonstrated application yard debris compost provided large benefit soil maintenance increased soil test effect years tissue nutrient concentrations blueberry leaves
background spleen plays pivotal role rapid clearance parasitized red blood cells patients falciparum malaria artemisinin treatment prolonged parasite clearance found patients splenectomy hemoglobin abnormalities reduced immunity distinguishable artemisinin resistance paper reports case prolonged parasite clearance chinese splenectomized patient falciparum malaria imported nigeria case presentation year old chinese male suffered days febrile illness returning zhumadian city henan province nigeria october main symptoms febrile including highest axillary temperature degrees headache chills peripheral blood smear showed parasitemia asexual parasites plasmodium falciparum patient used chemoprophylaxis malaria nigeria worked construction worker patient three episodes malaria nigeria splenectomy due traffic accident years ago time admitted hospital patient orally administrated total dihydroartemisinin piperaquine days intravenously administrated total artesunate days axillary temperature patient ranged degrees day day blood microscopy revealed falciparum malaria parasitemia asexual parasites day patient afebrile day falciparum malaria parasitemia continuously present gradually decreased next days negative day patient cured left hospital day plasmodium falciparum found blood day day mutation found propeller gene compared pfd propeller gene reference sequence conclusions first reported case china prolonged parasite clearance splenectomized patient imported falciparum malaria artemisinin resistance distinguished prolonged parasite clearance found malaria patient splenectomy
objective describe relationship advancing age persons chronic spinal cord injury sci prevalence low testosterone men sci compared historical normative data able bodied men general population design retrospective cross sectional study two hundred forty three healthy non ambulatory outpatient men chronic sci age years included retrospective analysis results forty six percent men sci identified low serum total testosterone concentrations total testosterone nmol age related decline sci total serum testosterone concentration year compared year massachusetts male aging study third eighth decade life men sci prevalence rate low serum total testosterone higher values reported decade life able bodied men baltimore longitudinal study aging conclusion compared general population low serum total testosterone concentration occurs earlier life men sci higher prevalence decade life age related decline circulating total testosterone concentration greater studies replacement therapy men sci assist determining possible functional clinical benefits reversing low serum total testosterone concentration
using fixed point techniques study existence multiplicity positive radial solutions two classes nonlocal elliptic systems defined bounded annular domains exterior domains end reduce problem second order functional ordinary elliptic systems approach also allows study systems involving various orders serve models suspension bridge equations
tsunami series great waves primarily caused major subduction zone earthquake large scale displacement sea floor initiation submarine landslides many coastal areas western united states subject tsunami hazard infrequent potentially extremely destructive public safety risk partially mitigated warning preparedness evacuation many coastal communities states alaska washington oregon california hawaii insufficient time complete evacuation places higher elevation taller structures could provide life safety community disaster resilience would also require critical essential facilities provide structural resistance collapse towards goal tsunami loads effects subcommittee asce structural engineering institute asce sei standards committee developed new chapter design requirements tsunami loads effects contained edition asce standard minimum design loads buildings structures minimum design loads buildings structures asce tsunami loads effects chapter become first national consensus based standard tsunami resilience use states alaska washington oregon california hawaii purpose paper provide explanation technical basis methodology tsunami resilient design critical essential facilities tsunami vertical evacuation refuge structures multistory building structures asce provisions tsunami loads effects implements unified set analysis design methodologies design maps based probabilistic hazard analysis loads based tsunami physics structural ultimate strength basis design probabilistic offshore tsunami amplitude maps tsunami design zone inundation maps developed using method consistent probabilistic seismic hazard analysis treatment seismic source uncertainties procedures tsunami inundation analysis based using mapped values offshore tsunami amplitude runup inundation limit shown tsunami design zone maps asce tsunami loads effects chapter consistent principles probabilistic hazard analysis tsunami physics fluid mechanics integrated comprehensive set design provisions
modern electronic systems claim analog digital interfaces strong requirements terms resolution frequency among several architectures intent achieve hard specifications time interleaved analog digital converters tiadc arises competitive candidate tiadc offer higher sampling frequency suitable moderate power consumption however architecture introduces mismatch errors affect resolution data conversion calibration methods permit reduce significantly impact errors possible solution insertion additional circuitry conversion system built self calibration bisc bisc system aims compensate imperfections tiadc offset gain timing errors despite benefits carried bisc system also introduces errors overall data conversion system paper proposes case study mixed signal bisc tiadc highlighting strengths weakness using built calibration circuits supplementary calibration methods explored mitigate impact bisc improve conversion performance debate open calibration systems must calibrated
report case rheumatic heart disease severe mitral stenosis cyanosis low oxygen saturation pulse oximetry findings clinical examination low values pulse oximetry inconsistent findings normal partial pressure oxygen oxygen saturation arterial blood gas analysis leading diagnostic dilemma clinical scenario anesthesiologist aware vigilant differential diagnosis low oxygen saturation pulse oximetry
visfatin adipocytokine plays role regulating periodontal inflammation yet identified mechanisms suggested visfatin mediates inflammation via activation nuclear factor kappa kappa phosphatidylinositol kinase pik signaling pathways play role inhibition neutrophil apoptosis aim study investigate expression visfatin kappa kappa kappa pik tumor necrosis factor alpha tnf alpha interleukin beta beta tissue healthy individuals patients periodontitis tissue biopsy samples obtained patients chronic periodontitis gingiva healthy individuals undergoing crown lengthening mrna expression levels visfatin kappa pik tnf alpha beta evaluated quantitative real time pcr qpcr also visfatin protein expression measured immunohistochemistry qpcr immunohistochemistry results revealed visfatin expression higher tissues periodontitis healthy tissues similarly mrna expression levels kappa pik beta higher tissues periodontitis healthy gingival tissues visfatin positively correlated levels kappa kappa pik tnf alpha beta tissues periodontitis results demonstrated increased visfatin associated expression kappa pik may play role pathogenesis periodontitis suggest increased visfatin may contribute inhibition neutrophil apoptosis via kappa pik signaling pathways understanding role visfatin periodontitis enable development new treatment methods inflammation
conservative management trends diverticulitis may lead increased hospitalizations secondary repeated attacks study aimed characterize trends management risk assess patients diverticulitis required multiple admissions identify high utilizers total patients diverticulitis identified new york sparcs database patients hospital admissions stratified across demographics comorbidities insurance status surgical intervention total patients hospital admissions risk factors admissions included younger age white race obesity hypertension pulmonary disease hypothyroidism rheumatoid arthritis depression fifty two percent patients went surgery percentage elective cases increased emergent cases conversely decreased one five patients admitted diverticulitis required two admissions numerous patient factors correlated increased risk readmission factors may used guide treatment decisions help reduce economic burden frequent utilizers trends surgery rates patients could reflect improved treatment options changing clinical practice patterns
light driven synthetic micro nanomotors attracted considerable attention recent years due unique performances potential applications herein demonstrate dye enhanced self electrophoretic propulsion light driven tio janus micromotors aqueous dye solutions compared velocities micromotors pure water times accelerated motions observed aqueous solutions methyl blue cresol red methyl orange respectively determined micromotor speed changes depending type dyes due variations photodegradation rates addition following deposition paramagnetic layer tio layers micromotor precisely navigated external magnetic field magnetic micromotors facilitate recycling micromotors also allow reusability context dye detection degradation general photocatalytic micro nanomotors provide considerable potential rapid detection thefly degradation dye pollutants aqueous environments
paper presents three dimensional model refrigerant oil two phase flow developed aim predicting oil retention evaporators air conditioning systems developed model based two fluid model approach governing mass momentum energy balance equations written phase gas phase refrigerant vapor liquid phase mixture liquid refrigerant oil balance equation oil mass fraction mixture liquid refrigerant included transfer processes vapor liquid interfaces flow channel walls predicted closure laws model solved house computer code based simple type numerical procedure model validated comparing numerically predicted refrigerant mass oil retention data brazed plate fin evaporator typically used automotive applications measured values two sets experiments performed refrigerants ryf mixture pag oil simulated numerical results provide complete picture two phase flow structure evaporator model predicts oil mainly retained bottom header smaller amounts top header parallel evaporating channels upward refrigerant flow developed three dimensional modeling numerical approach advantage reliable prediction oil retention existing one dimensional models elsevier ltd rights reserved
employment solar energy recent years reached remarkable edge become even popular cost fossil fuel continues rise energy storage system improves adjustability marketability solar thermal allowing produce electricity demand study attempted prepare cordierite mullite composite ceramics used solar thermal storage material calcined bauxite talcum soda feldspar potassium feldspar quartz mullite thermal physical performances evaluated characterized xrd sem epma eds found optimum sintering temperature degrees preparing corresponding water adsorption apparent porosity bulk density bending strength mpa residual bending strength specimen sintered degrees thermal shock times decreased mpa lower thermal conductivity samples sintered degrees tested center dot center dotk degrees wrapped pcm phase change materials kso thermal storage density center dot temperature difference ranged degrees prepared cordierite mullite composite ceramic proved promising material solar thermal energy storage
adolescents type diabetes increased risk deteriorating glycemic control poor quality life depressive symptoms stress coping related outcomes adolescents diabetes yet studies examined constructs longitudinally study aimed describe stress coping adolescents type diabetes examine coping strategies predictors adolescent adjustment depressive symptoms quality life glycemic control adolescents type diabetes completed measures diabetes related stress coping symptoms depression quality life baseline months months data glycemic control collected adolescents medical charts adolescents use primary control coping problem solving secondary control engagement coping positive thinking strategies predicted significantly fewer problems quality life fewer depressive symptoms time contrast use disengagement coping strategies avoidance predicted problems quality life depressive symptoms coping significant predictor glycemic control coping mediated effects diabetes related stress depressive symptoms quality life ways adolescents type diabetes cope diabetes related stress predict quality life symptoms depression glycemic control use screening identify adolescent diabetes related stress targeted interventions improve coping strategies potential improve outcomes
objective evaluate patients characteristics associated clinical decision request mri hla patients spa daily practice methods patients referred rheumatology outpatient clinic national referral centre selected patients clinical diagnosis spa according rheumatologist included mri hla available patients rheumatologists ordered tests characteristics associated ordering mri hla identified univariable analyses variables value completeness selected analysis multi variable logistic regression analysis used evaluate determinants related decision perform mri hla odds ratios confidence intervals calculated results total patients spa included cohort men mean age disease duration years patients mri hla tests ordered independently predictive factors ordering mri presence ibp enthesitis number initial symptoms presentation per additional symptom present independently predictive factors hla testing number initial symptoms per symptom uveitis conclusion study strongly suggests rheumatologists use certain clinical clues decide order expensive scarce tests diagnostic work spa patients manifestations may increase efficiency tests clinical practice suggest clinical reasoning follows principles bayesian theory
paper introduces new method clustering documents written language evolving different historical periods example italian language first phase text transformed string four numerical codes derived energy profile letter defining height letters location text line code represents gray level text codified image second phase texture features extracted obtained image order create document feature vectors subsequently new clustering algorithm employed feature vectors discriminate documents different historical periods language experiments performed database italian documents given italian vulgar modern italian results demonstrate proposed method perfectly identifies historical periods language documents outperforming well known clustering algorithms generally adopted document categorization state art text based language models
assessment suicide risk daunting increasingly frequent task outpatient practitioners guidelines depression screening identify individuals risk treatment mental health resources always easily accessible patients identified need formal suicide risk assessment article reviews established risk protective factors suicide provides framework assessment management individuals risk suicide assessment explicitly documented summary relevant risk protective factors individual focus interventions may mitigate risk
structural design compressor pump gas damper pneumohydraulic electrical circuits testing unit studying compressor pump presented comparison indicator diagrams compressor pump chambers along integral characteristics obtained experimentally mathematical modeling presented
investigation paper generalized dimensional coupled burger equation variable coefficients describes lots nonlinear physical phenomena geophysical fluid dynamics condense matter physics lattice dynamics employing lie group method symmetry reductions exact explicit solutions obtained respectively based direct method conservations laws equation also derived furthermore virtue painleve analysis successfully obtain integrable condition variable coefficients plays important role studying integrability equation finally auto backlund transformation well new analytic solutions including solitary periodic waves also presented via algebraic differential manipulation elsevier ltd rights reserved
vacuum impregnation used improve quality attributes fresh cut papayas vacuum pressure kpa applied min calcium lactate pectin methylesterase pme alone combinations calcium lactate plus pme vacuum impregnated fresh cut papaya cubes papaya cubes stored degrees quality fresh cut papaya studied intervals days hardness chewiness levels fresh cut papayas treated calcium lactate pme times untreated fresh cut papayas day respectively vacuum impregnation colour fresh cut papayas changed significantly overall weight loss observed well chelate soluble pectin csp extracted content correlated well texture properties fresh cut papayas qualitative quantitative analyses csp conducted using atomic force microscopy proportion chain widths greater increased fresh cut papayas vacuum impregnated calcium lactate pme end storage results indicate combination calcium ions pme able maximally preserve quality attributes fresh cut papayas extend shelf life
monte carlo method provide high fidelity neutronics analysis different types nuclear reactors owing advantages flexible geometry modeling use continuous energy nuclear cross sections however nuclear reactors complex systems multi physics interacting coupling codes couple depletion solver thermal hydraulics codes simultaneously transport burnup thermal hydraulics coupling calculations mit beavrs typical trans port burnup thermal hydraulics coupling benchmark paper rmc coupled sub channel code cobra equipped fly temperature dependent cross section treatment large scale detailed burnup calculation based domain decomposition rmc applied full core burnup calculations beavrs benchmark hot full power hfp condition numerical tests show domain decomposition method achieve consistent results compared original version rmc enlarging computational burnup regions results hfp rmc agree well reference values beavrs benchmark also agree well work proves feasibility accuracy rmc multi physics coupling lifecycle simulations nuclear reactors elsevier ltd rights reserved
ultraviolet radiation sun essential part process obtaining vitamin human body however prolonged exposure poses risk health skin eyes lead premature aging even cancer moreover quick technological development shows barriers visually impaired users require special help via audio devices order access kind technology reasons paper present wearable sensor prototype integrated audio notification system based smartphone app blind people notification system capable offering appropriate skin care recommendations based ultraviolet index uvi exposure time skin color
study structure fuzzy functions improved function expansion unlike fuzzy conventional rules classical fuzzy function structure includes fuzzy bases linear inputs membership functions fuzzy bases set using fuzzy means fcm algorithm linear parameters computed using least square estimation lse study two main contributions first conventional fuzzy functions structure powered expansion orthogonal trigonometric functions approximation capabilities fuzzy functions increased second widths normalized membership functions determined fuzzy function model optimized using nelder mead simplex algorithm provides enhancement identification performance advantages proposed model shown via offline identification benchmark nonlinear system online identification two real time nonlinear systems
two dimensional model developed thermal stresses elastic strains creep strains creep energy density interfaces short long trilayer assemblies plane stress plane strain conditions linear viscous non linear creep constitutive behavior static cyclic thermal loading modeled layers interfacial stresses strains approximated using combination exact elasticity solutions elementary strength materials theories partial differential equations linearized simple finite difference discretization procedure approach mathematically straightforward extended include plastic behavior problems involving external loads variety geometries model provide input data thermal fatigue life prediction solder adhesive joints typical solder joint demonstrated predicted cyclic stress strain hysteresis shows shakedown rapid stabilization creep energy dissipation per cycle agreement predictions finite element analysis elsevier ltd rights reserved
emergency hormonal contraception ehc available pharmacies without prescription years republic ireland service made available jurisdictions respective regulators included conscience clauses allow pharmacists opt providing ehc religious moral grounds providing certain criteria met effect conscientious objectors must refer patients providers willing supply medicines inclusion clauses leads cycle cognitive dissonance behalf parties objectors convince existence moral difference supply ehc referral another supplier regulators must feign satisfaction form regulation lacking universality lead adverse consequences long term contend whichever two parties truly believes purport must act end unsatisfactory status quo either regulators must compel pharmacists dispense emergency contraception suitable patients request pharmacist must refuse either supply ehc refer patient alternative supplier challenge subsequent sanctions imposed regulator
purpose study investigate influence spirituality religiosity personal beliefs previous contact health issues level empathy medical students jefferson scale empathy student version whoqol spirituality religiousness personal beliefs duke university religion index applied brazilian medical students findings suggest meaning life previous mental health treatment religiosity positively related empathy suggest attention given prevention treatment mental health issues studies needed understand replicate findings
background data regarding cardiac resynchronization therapy crt patients multiple comorbidities limited objectives study evaluated association multiple comorbidities benefits crt implantable cardioverter defibrillator icd alone methods examined madit crt multicenter automatic defibrillator implantation trial cardiac resynchronization therapy study patients left bundle branch block lbbb comorbidities including renal dysfunction hypertension htn diabetes coronary artery disease history atrial arrhythmias history ventricular arrhythmias current smoking cerebrovascular accident adjusted analysis analyzed risk heart failure events death comorbidity group patients patients crt defibrillator crt versus icd examined percent change left ventricular end diastolic volume end systolic volume ejection fraction left atrial volume dyssynchrony year crt patients comorbidity group results inverse relationship comorbidity burden improvements end systolic volume end diastolic volume left ventricular ejection fraction left atrial volume dyssynchrony adjusted model increasing risk death nonfatal events increasing comorbidity burden regardless treatment group absolute risk reduction associated crt icd alone appeared greater seen groups less comorbidity burden conclusions long term follow madit crt study patients lbbb randomized crt differences death risk degree reverse remodeling among comorbidity groups however burden comorbidity appear compromise clinical benefits crt compared icd alone american college cardiology foundation
background concept mental toughness gained increasing importance among groups elite athletes virtue psychological importance explanatory power broad range health related behaviors however study focused far psychological origins therefore aims present study explore extent psychological profiles preschoolers aged five associated scores sleep disturbances age explore possible gender differences method nine years first assessment age five preschoolers total adolescents mean age years females took part follow study baseline parents teachers completed strengths difficulties questionnaire sdq covering internalizing externalizing problems hyperactivity negative peer relationships prosocial behavior followup participants completed booklet questionnaires covering socio demographic data sleep disturbances results higher prosocial behavior lower negative peer relationships lower internalizing externalizing problems age five rated parents teachers associated self reported higher lower sleep disturbances age age relative males females lower scores reported sleep disturbances conclusion pattern results suggests traits adolescence may origins pre school years
objectiveanorexia nervosa serious disorder mortality rate highest psychiatric illness notoriously challenging treat mechanisms illness well understood reward system abnormalities proposed across theoretical models persistence feedback learning important component reward systems shape behavior hypothesized individuals would show poorer learning feedback methodswe administered acquired equivalence task measure learning incremental feedback generalization learning novel stimuli participants individuals intensive weight restoration treatment healthy comparison participants tested twice performance assessed accuracy learning test phases trained novel stimuli relationship task performance eating disorder severity baseline also assessed resultsboth treatment individuals showed reduced learning feedback learning phase lower accuracy test phase compared individuals differ accuracy novel stimuli indicating deficit generalization decreased acquisition feedback learning associated longer illness duration greater eating disorder symptom severity baseline conclusionsindividuals show reduced learning feedback reinforcement may contribute difficulties changing maladaptive behaviors
tuning method controller suggested yunwana seborg could applied system time delay due phase error pade approximiation paper theoretically analyzes phase error find phase error pade approximation time delay major causes suggests novel optimal tuning method solve problems configuration regulators means bilinear transformation based previous study suh
organizational processes prenatal development long term effects individual phenotype early developmental stages sensitive environmental influences mothers unique position alter offspring phenotype differentially allocating resources developing young however prenatal maternal effects difficult disentangle forms parental care additive genetic effects forms maternal inheritance hampering understanding evolutionary consequences used divergent selection lines high low prenatal maternal investment reciprocal line crosses precocial birdthe japanese quail coturnix japonica quantify relative importance genes prenatal maternal effects shaping offspring phenotype maternal paternal origin strongly affected offspring body size survival throughout development although effects maternal egg investment faded time large key life stages additionally evidence forms maternal inheritance affecting offspring phenotype later stages development study among first successfully disentangle prenatal maternal effects sources confounding variation highlights important role prenatal maternal provisioning shaping offspring traits closely linked fitness
inherent economic environmental advantages internal combustion engine fuel make natural gas attractive alternative diesel fuel primary energy source compression ignition engine applications diesel pilot ignition attractive fueling strategy typically requires minimal modification existing engines furthermore strategy makes use highly developed direct injection diesel fuel systems already employed modern engines control dual fuel combustion despite increasing popularity dual fuel engine concept fundamental understanding fuel conversion mechanisms impact fueling parameters still incomplete conceptual understanding relevant physics necessary development fueling pilot ignition strategies address shortcomings dual fuel combustion low load emissions combustion stability experimental facility supporting optical diagnostics via bowditch piston arrangement litre single cylinder research engine ricardo proteus used study consider effect fueling parameters fuel conversion process dual fuel engine fueling achieved port injected diesel direct injection using common rail system simultaneous high speed natural luminosity chemiluminescence imaging used characterize dual fuel combustion influence pilot injection pressure bar bar relative diesel cat ratios pilot ratio noted key operating dual fuel control metrics pilot injection pressure observed significant impact fuel conversion process higher pilot injection pressures auto ignition sites concentrated around piston bowl periphery reaction zone propagated towards center bowl lower pilot injection pressures ignition initiated vicinity pilot fuel jet structures resulted heterogeneous fuel conversion process regions intense natural luminosity attributed particulate matter increase pilot ratio increased diesel fraction resulted aggressive combustion event due larger fraction energy released premixed auto ignition event coupled decrease fraction combustion chamber significant light emission indicating incomplete fuel conversion regions insight dual fuel conversion processes presented work ultimately used develop dual fuel injection strategies well provide much needed validation data modeling efforts
microstrip shunt open stub overlapping shorted slotline presented used design novel wideband dispersive delay line inherent periodic transmission zeros due resonances open stub shorted slotline removed using complementary configuration moreover phase response complementary stub frequency dependant used design dispersive delay line group delay profile complementary stub smooth continuous time maintaining flat magnitude response ultra wide bandwidth several units cascaded obtain desired group delay profile configuration used analog signal processing reduce signal distortion wideband components
fluid mechanics lot authors executing researches obtain analytical solutions navierstokes equations even case compressible gas flow essential deficiency non stationary solutions indeed derivation explore case non stationary helical flow navierstokes equations incompressible fluids given initial conditions velocity fields means open choice space part solution non stationary helical flow proved decreasing exponentially regard time parameter extent time dependent exponential component given coefficient kinematic viscosity multiplied square coefficient proportionality vorticity velocity field elsevier inc rights reserved
method analysis algorithm metrological evaluation interference radio frequency waves distribution network supplying telecommunications facilities consider model electrical circuits supply substation algorithm computing equivalent parameters circuits switching impacts lighting strokes
study examined three potential moderators relations maternal parenting stress preschoolers adjustment problems genetic polymorphismthe short allele serotonin transporter httlpr allele gene physiological indicatorchildren baseline respiratory sinus arrhythmia rsa behavioral indicatormothers reports children negative emotionality total mothers age years sdage reported parenting stress well preschoolers age years sdage boys negative emotionality internalizing externalizing sleep problems results indicated genetic sensitivity variable functioned according differential susceptibility model however results involving physiological behavioral sensitivity factors consistent diathesis stress framework implications prevention intervention efforts counter effects parenting stress discussed
dramatic evolution medical catheter interventions complex surgeries treat children congenital heart disease chd led growing number patients multitude long term complications associated morbidity mortality heart failure patients hypoplastic left heart syndrome predicated functional single ventricle lesions associated increase chd prevalence remains significant challenge pathophysiological mechanisms contributing progression chd including single ventricle lesions dilated cardiomyopathy adult heart disease may inevitably differ although therapeutic options advanced cardiac failure restricted heart transplantation mechanical circulatory support strong impetus develop novel therapeutic strategies lower vertebrates newt zebrafish remarkable ability replace lost cardiac tissue intrinsic self repair machinery early postnatal stage mice confirmed partial ventricular resection although underlying mechanistic insights might differ among species mammalian heart regeneration occurs even humans highest degree occurring early childhood gradually declining age adulthood suggesting advantage stem cell therapy ameliorate ventricular dysfunction patients chd although effective clinical translation variety stem cells adult heart disease remains inconclusive respect improvement cardiac function case reports clinical trials based stem cell therapies patients chd may invaluable next stage therapeutic development dissecting differential mechanisms underlying progressive ventricular dysfunction children adults may lead identify novel regenerative therapy future regenerative technologies treat patients chd exciting prospects heart regeneration general practice
paper presents harmonic instability analysis method using state space modeling participation analysis inverter fed power systems full order state space model droop controlled distributed generation inverter built first including time delay digital control system inner current voltage control loops outer droop based power control loop based inverter model overall state space model two inverter fed system established eigenvalue based stability analysis presented assess influence controller parameters harmonic instability power system moreover harmonic frequency oscillation modes identified participation analysis presented evaluate contributions different states modes reveal system gives rise harmonic instability based participation analysis reduced order model harmonic instability analysis also proposed experimental results presented validating theoretical analyses
background emergency responders frequently incur injuries providing medical fire law enforcement services national surveillance systems provide fragmented perspectives responder injuries omit specific classes workers government volunteers report selected injuries employment information incomplete methods characterized injuries among emergency medical services ems fire fighting police occupations using data national electronic injury surveillance system occupational supplement neiss work injuries treated hospital emergency departments results sprains strains leading injury among ems firefighter police occupations police officers career firefighters highest injury rates injuries per full time equivalent workers respectively conclusions physical demands emergency response area leading cause injuries may benefit similar interventions across occupations assess risk improved exposure data need acquired particularly volunteers ind med published wiley liss inc dagger
aim finding optimal design interior permanent magnet electric motor means sensitivity based topology optimization method gradient based method successfully applied optimization problems form show method improved considering mathematical concept topological derivatives tds tds optimization problems constrained linear partial differential equations pdes well understood whereas little known tds combination nonlinear pde constraints derive optimization problem constrained equation nonlinear magnetostatics illustrate advantages sensitivities used method show numerical results optimization interior permanent magnet electric motor obtained level set algorithm based
objective adolescents conduct disorder high risk developing adult antisocial personality disorder however underlying neuropathophysiology remains poorly understood hypothesized microstructure white matter males may differ healthy control subjects hcs method tract based spatial statistics tbss quantitative tractography used assess microstructural differences teenaged boys demographically matched hcs results group behavioral scale scores significantly higher hcs barratt impulsivity scale strength difficulties questionnaire antisocial process screening device total scales tbss revealed relative hcs group higher fractional anisotropy corpus callosum region bilaterally including genu body well projection fibers region left anterior coronal radiate right superior coronal radiate tractography confirmed higher fibers passing regions significant differences tbss results exploratory analysis revealed impulsivity associated positively fibers group conclusions maturation microstructure subjects differed hcs mainly abnormal maturation structures may play important role impulsivity aggression teenagers
current consensus diagnosis prognosis treatment essential thrombocythemia based experts recommendations however several aspects diagnosis prognosis therapy still controversial delphi method employed expert panel members spanish group negative myeloproliferative neoplasms order identify degree agreement diagnosis prognosis treatment nine leading experts selected total clinical hematologists well known expertise electronic questionnaire used collect questions rated four step scale questions grouped four blocks diagnosis risk stratification goals therapy treatment strategy first round consisting questions second round including additional questions focused recommendations advocated experts european leukemianet analyzed median mean values first second rounds calculated summary conclusions considered representative block questions presented delphi method powerful instrument address current approaches controversies surrounding
latency measured user motion display output causes virtual reality cybersickness decreases task performance however effect small delay investigated sufficiently therefore purpose study reveal effect small latency subjects subjects asked stand force plate one foot length body sway measured several lags ranging experiments showed sway increased linearly latency got longer hmd latency also degraded sense balance compared naked eye limited field view fov hmd difference virtual real worlds content effect result experiment results user stability regarded direct index quality system user
objectives obtain information injuries west end performers methods retrospective survey performers appearing west end productions dramas eight musicals results current productions performers sustained least one injury average injuries per performer lower extremity injuries common dancers injuries actors neck back injuries second common sprains strains common diagnoses performers thought injuries preventable performers consulted nonphysician healthcare providers factors significantly influencing risk injuries performers include female sex history previous injuries missed performances due previous injuries physically demanding roles performing raked tangled stages conclusion west end performers commonly sustain injuries although primary prevention theatrical injuries possible modification raked stages may reduce incidence study may helpful growing number healthcare providers practice performing arts medicine may stimulate additional concern research medical theatrical communities performance injuries professionals amateurs theatrical students worldwide
green roofs proposed efficient practical tool combat urbanisation many countries review paper focuses various benefits associated green roofs research efforts made till date promote green roofs systematic comparison literature review also emphasises knowledge gap prevail green roof technology highlight need local research install green roofs developing developed countries considering growth substrate vegetation drainage layer determine success green roof efforts made consolidate desirable characteristics components suggests methodology construct practical green roofs critical review also explores limitations associated green roofs recommend strategies overcome apart stand alone green roofs huge scope hybrid green roof systems established techniques presented discussed recommendations future study also provided elsevier ltd rights reserved
study estimates impact shear stress solid particles erosion corrosion behaviour spark plasma sintered pure nickel simulated mine water rotating cylinder electrode system employed carry erosion corrosion tests weight loss electrochemical measurements corroded coupons examined aid microscope assess surface morphology gravimetry data inconsistent weight gain weight loss recorded impact hydrodynamic parameters correlated pitting resistance passivation behaviour sintered nickel morphology results showed minimal general attack severe localised corrosion
research present preoperative robotic surgery simulator platform means training raven surgical system simulator employs phantom omni geomagic touch master device control arms simulated model raven virtual environment earlier simulators raven built primarily work debian based linux operating systems first attempt towards development simulator matlab cross platform application allows accessibility simulator broader community surgeons researchers simulator designed provide haptic feedback user results ina realistic emulation surgery environment key features include opening closing surgical tool using pen buttons ofphantomomni freeflow feature surgeon willingly pause motion surgical robot adjust position input device per requirement simulator successfully built tested matlab results simulation satisfactorily verified efficacy proposed system
recent years stylized draw technology attracted eyes non photorealistic rendering paper generation method image chinese ink wash effect based blur edge detection provided implemented programming matlab sdk platform using method platform given color image could converse picture stylized chinese ink wash effect automatically user even painting background experimental results proved methods effective satisfied use simple easy operate learn
paper new compact voltage mode four phase oscillator employing single copy voltage differencing transconductance amplifier vdta grounded passive elements introduced use grounded capacitors resistors makes proposed circuit ideal integrated circuit implementation condition oscillation frequency oscillation independently adjustable passive active sensitivities proposed circuit configuration low experimental measurement results using readily available maxim integrated ics max given prove theory
voltage scaling fundamental technique energy efficient computing field recent studies tackling topic show degraded system reliability frequency scales address conflict subject reliability aware power management rapm extensively explored still investigation heterogeneous computing systems hcs provide high performance potential attracts researchers consider systems unfortunately existing scheduling algorithms precedence constrained tasks shared deadline hcs adequately consider reliability conservation study design joint optimization schemes energy efficiency system reliability directed acyclic graph dag adopting shared recovery technique achieve high system reliability noticeable energy preservation best knowledge first time address problem hcs extensive comparative evaluation studies randomly generated real world applications graphs show scheduling algorithms compelling terms enhancement system reliability energy saving elsevier ltd rights reserved
petroleum coke byproduct oil sands upgrading utilized low cost feedstock value added operations gasification design scale gasifiers oil sands coke demands reliable data intrinsic reaction rates currently missing literature intrinsic gasification rates char char reactions determined canadian oil sands fluid coke four different specific surface area measurement techniques used normalize specific reaction rate calculated weight loss profiles tga bet surface area two micro porosity measurement techniques based density functional theory dft dubinin radushkevich models finally active surface area asa measured chemisorption different levels conversion char conversion specific reaction rates calculated different levels conversion divided different surface areas order find specific surface area results best reduction variability reaction rate using surface area regressor variable overall asa found best regressor deriving intrinsic rates surface areas based bet technique also proven better choice normalizing specific rates compared ones based dft models
detailed analyses slopes arcuate planform morphologies titan equatorial mountain ridge belts consistent formation contractional tectonism however contractional structures ice require large stresses mpa sources likely exist titan cassini spacecraft imagery reveals methane based hydrological cycle titan likely includes movement fluids subsurface crustal liquids may enable contractional tectonic features form groundwater thrust belts earth study show liquid hydrocarbons titan near subsurface lead fluid overpressures facilitate contractional deformation smaller stresses mpa significantly reducing shear strength materials titan crustal conditions enhanced pore fluid pressures favor formation thrust faults related folds contractional stress field thus surface near surface hydrocarbon fluids made stable thick atmosphere may play key role tectonic evolution titan elsevier inc rights reserved
background hypogonadism common patients renal dysfunction always correct following transplantation recent studies show increased mortality dialysis transplant patients low testosterone patients often treated due concerns efficacy complications real imagined surprisingly scant literature supporting use therapy patients wished examine results therapy patients renal failure following transplant methods identified men men health registry treated either dialysis functioning transplant time therapy demographic laboratory clinical outcome data collected electronic medical record results men dialysis functioning transplant mean age years range years mean total serum range bothersome symptoms including fatigue erectile dysfunction mean hematocrit anemic therapy included patches topical gels testopel pellets mean follow months range months mean post therapy range mean hematocrit improved anemic patients improved anemic range cardiovascular infectious complications conclusions symptomatic hypogonadism common dialysis transplant patients replacement therapy safely given improvement values symptoms patients anemia usually improved testopel pellets used immunosuppressed transplant recipients without infectious complications
investigated interrater agreement personality judgment affected perceivers affection dislike regarding targets total perceivers judged personalities targets means adjectives targets public figures pope enabled gathering large number ratings perceivers differing liking shared liking associated strong increases large liking differences associated strong decreases profile correlations shared antipathy also associated lower agreement greater agreement judgments liked targets largely due perceivers characterizing targets positively whereas judgments disliked targets affected shared negativity extent perceivers attitudes toward targets constitute important factor person perception need taken account systematically research studies
politics regarded many parts world especially africa space meant exclusively men therefore women venturing politics made believe misfits idea anathematized strangulated outset supposed encourage women popularly believed natural men rule women considered abnormal unnatural women rule men although different societies one time history ruled queens female warriors least usually seen bizarre societies practice monarchical imperial rule democracy however lot people vehemently oppose idea woman vying political office case africa two factors responsible african people colonial experience bifurcation social sphere public private spaces entrenched gender roles scheme social reality held people people hold certain roles must performed women certain roles exclusively men culture made increasingly difficult achieve parity egalitarianism gender relations contemporary africa achieve meaningful development africa article suggests ideological decolonization way current predicament african women subaltern patriarchal hostile political space contemporary africa
although previous research demonstrated generosity lead status gains converse effect status generosity received less attention significant gap groups society large rely beneficence members especially holding high status positions broadly research psychology status remains largely unexplored striking light attention given forms social hierarchy power current work focuses psychology status explores interactive effects status legitimacy generosity particular hypothesize status decrease generosity status hierarchy perceived legitimate status inflate views one value group sense deservingness contrast hypothesize status increases generosity status hierarchy perceived illegitimate due efforts restore equity one generosity results support hypotheses across studies field study experiments empirically demonstrate effects status legitimacy generosity attributed concerns equity status allocation
solving large scale comparison problems using distributed computing increasingly significant various applications previous efforts implement distributed comparison frameworks treated two phases data distribution comparison task scheduling separately leads high storage demands well poor data locality comparison tasks thus creating need redistribute data runtime furthermore previous methods developed homogeneous computing environments overall performance degraded even used heterogeneous distributed systems tackle challenges paper presents data aware task scheduling approach solving comparison problems heterogeneous distributed systems approach formulates requirements data distribution comparison task scheduling simultaneously constrained optimization problem metaheuristic data pre scheduling dynamic task scheduling strategies developed along algorithmic implementation solve problem approach provides perfect data locality comparison tasks avoiding rearrangement data runtime achieves load balancing among heterogeneous computing nodes thus enhancing overall computation time also reduces data storage requirements across network effectiveness approach demonstrated experimental studies elsevier inc rights reserved
empirical evidence provided show peer effects statistically significant positive impacts diffusion green building certificates application approval records green certificates commercial buildings used challenge self selection addressed usage fixed effects challenge reflection addressed time lag delay building application approval empirical results show additional approved leed certificate within zip code increase probability commercial building zip code apply leed certificate percentage points additional approved energy star certificate within zip code increase probability commercial building zip code apply energy star certificate percentage points
development trusted network research trusted evaluation mechanism user behavior hotpot network security order solve problems subjectivity limitations static traditional trusted network user behavior evaluation models find real time dynamic evaluation method user behavior paper authors construct real time evaluation mechanism based double evidence classification user behavior dec evaluation mechanism includes process classification characteristic classification user behavior evidence makes user behavior evidence time directly involved trust evaluation evaluation result comprehensive accurate simulation experiments evaluated three kinds user behaviors based dec compared two kinds trust evaluation methods user behavior results show proposed methods evaluate user behavior comprehensively accurately dynamically complex network environments results realistic
stock separation highly mobile clupeids sprat sprattus sprattus herring clupea harengus using otolith morphometrics explored analysis focused three stock discrimination problems aim reassigning individual otoliths source populations using experiments undertaken using machine learning environment known weka waikato environment knowledge analysis six feature sets encoding combinations size shape together nine learning algorithms explored assess saliency size shape features half feature sets included size indices remainder encoded shape otolith sample sets partitioned age impact age classification accuracy could assessed method total performed experiments representing comprehensive evaluation otolith morphometrics learning algorithms results show juveniles methods encoding shape performed well included size indices held classification potential however fish age shape encoding methods robust including size information study suggests methods stock discrimination based early incremental growth likely effective automated classification techniques show little benefit supplementing early growth information shape indices derived mature outlines elsevier rights reserved
background increasing dissatisfaction non specificity major depression led many propose specific depressive subtyping models present meta review seeks map dominant depressive subtype models highlight definitions overlaps methods database search medline embase proposed depressive subtypes limited reviews published undertaken four thousand reviews judged potentially relevant provided base present selective meta review results fifteen subtype models identified subtypes could divided five molar categories symptom based subtypes melancholia psychotic depression atypical depression anxious depression aetiologically based subtypes exemplified adjustment disorders early trauma depression reproductive depression perinatal depression organic depression drug induced depression time onset based subtypes illustrated early late onset depression well seasonal affective disorder gender based female depression treatment resistant depression overview considering definition bio psycho social correlates evidence base treatment options subtype provided limitations despite large data base meta review nevertheless narrative focused conclusions subtyping depression promising attempt overcome non specificity many diagnostic constructs major depression relation intrinsic non specificity failure provide treatment specific information subtyping model advanced would need however demonstrate differential impacts causes treatments elsevier rights reserved
majority medications children administered unlicensed label manner paediatricians obliged prescribe using limited evidence available regulation use paediatric drugs means pharmaceutical companies obliged receive incentives contributing paediatric drug data carrying paediatric clinical trials important efficacy adverse effect profiles medicines vary across childhood additionally significant age related changes pharmacodynamic pharmacokinetic activity many drugs may related physiological differential expressions cytochrome enzymes variable glomerular filtration rates different ages example psychological increasing autonomy risk perception teenage years changes increasing numbers children surviving life threatening childhood conditions due medical advances means increasing population risk consequences long term early exposure nephrotoxic agents kidney organ particularly vulnerable damage consequence drugs drug induced acute kidney injury aki episodes children babies principally due non steroidal anti inflammatory drugs antibiotics chemotherapeutic agents renal tubules vulnerable injury concentrating ability high energy hypoxic environment review focuses drug induced aki methods minimise effect including general management plus role child specific pharmacokinetic data use pharmacogenomics early detection aki using urinary biomarkers electronic triggers elsevier inc rights reserved
study objectives maintaining adequate serum levels vitamin may important sleep duration quality however associations well understood examined whether levels serum associated objective measures sleep older men setting participants cross sectional study within large cohort community dwelling older men mros study interventions among men age years older measured total serum vitamin objective estimates nightly total sleep time sleep efficiency wake time sleep onset waso obtained using wrist actigraphy worn average consecutive periods results study population low levels vitamin lower serum vitamin levels associated higher odds short versus lowest quartile confidence interval trend well increased odds actigraphy measured sleep efficiency less trend controlling age clinic season comorbidities body mass index physical cognitive function lower vitamin levels also associated increased waso age adjusted multivariable adjusted models conclusions among older men low levels total serum associated poorer sleep including short sleep duration lower sleep efficiency findings confirmed others suggest potential role vitamin maintaining healthy sleep
social anxiety disorder associated interpersonal dysfunction clear people disorder feel unsatisfied relationships one possibility higher social anxiety could lead changes sensitivity interpersonal traits examined whether social anxiety moderates types interpersonal evaluations people make regarding warmth dominance developed vignettes central characters systematically varied dominance warmth asked two samples participants undergraduate students online workers rate willingness interact social desirability characters participants general reported stronger desire interact warmer less dominant characters rated warmer dominant characters socially desirable people higher social anxiety exhibited greater tolerance colder submissive characters rated dimensions perceived similarity characters accounted bulk effects participants indicated higher desire interact characters similar people higher social anxiety likely rate submissive cold characters like results implications clinical interventions social anxiety disorder elsevier ltd rights reserved
human coronary sinus evolutionary modification terminal part left sinus horn anatomically coronary sinus short broad vessel runs along coronary groove situated diaphragmatic surface heart structure opens right atrium collects blood great cardiac vein veins heart well study assessed growth dimensions coronary sinus fourth eighth months fetal development whole material received nicolaus copernicus university collegium medicum department histology embryology bydgoszcz group specimens male female fetuses presented visible malformations developmental abnormalities results study determined dimension coronary sinus prenatal development sexually dimorphic furthermore following monthly period rapid growth length structure increases length six months gestation finally concluded dimensions coronary sinus obtained autopsy similar determined intravital ultrasound examination diameter coronary sinus best parameter monitoring fetal age growing fetus accordingly suggest best way estimate proper blood drainage heart veins study coronary sinus volume
objective rapid development economic construction requires modern major engineering must implement synergetic management model increase operation efficiency major engineering works also lower risk engineering works raise management ability engineering team methods thesis optimize coordinated management considering stereoscopic structure major projects build synergetic model results article establishes synergetic management model information dimension phase dimension linkage dimension beneficial enrich theoretical connotation major construction management provide maximum guarantee success construction conclusion testing synergetic management major infrastructural project thesis comes synergetic management enriches theories major projects
study ball type centrifugal clutch examined mathematically experimentally experiments depending ball diameter variations transmitted torques measured various gap factor spindle speed levels torque transmitted ball type centrifugal clutch equal total torques transmitted inner two side surfaces smaller ball diameter greater torque transmitted ball type centrifugal clutch used areas running operation electric motor required load clutch saves energy initial operation behaves like safety clutch loading levels sliding maximum transmittable torque adjusted changing mass ball housing
paper presents simple electronically tunable voltage mode first order pass filter realization mosfet technique comparison classical mosfet filter circuits employ active elements including large number transistors proposed circuit composed single two channel mosfet based inverting voltage buffer three passive components one nmos based voltage controlled resistor advantage used electronically control pole frequency filter range khz mhz proposed filter also suitable low voltage operation since supply rails uses two mosfets paper effect load investigated addition order suppress effect non zero output resistance inverting voltage buffer two compensation techniques also introduced theoretical results verified spice simulations using ptm level cmos process bsimv parameters supply voltages used moreover behavior proposed filter also experimentally measured using readily available array transistors cdub texas instruments
improvements overall sustainability include reductions energy consumption remain significant yet largely unexploited opportunities reduce energy consumption commercial buildings investments required green certification help systematically improve sustainability design buildings percentage buildings green certificates increases sustainability overall building sector improved order facilitate diffusion green commercial buildings important understand patterns diffusion key factors influencing buildings decisions applying spatial fraction logit model instrumental variable approach data commercial buildings new york arizona colorado florida paper demonstrates strong spatial correlation diffusion green building certificates also finds split incentive problem building owners renters plays role diffusion findings important implications policy makers analyzing interactions green buildings characteristics green building clusters results useful identification buildings likely adopt green certificates
background major depressive disorder mdd anxiety disorders highly morbid research shown conflicting evidence white matter alteration amygdala volume reduction mood anxiety disorders date studies examined differences structural connectivity anxious depressed non anxious depressed individuals study compared fractional anisotropy density selected white matter tracts amygdala volume anxious depressed non anxious depressed individuals methods direction dti scans collected unmedicated subjects mdd morbid anxiety disorder diagnosis region interest roi tractography methods performed calculate amygdala volume uncinate fasciculus respectively diffusion connectometry performed identify whole brain group differences white matter health correlations computed biological clinical measures results tractography roi analyses showed significant differences bilateral values bilateral amygdala volumes comparing anxious depressed non anxious depressed groups diffusion connectometry analysis showed significant differences anisotropy groups furthermore significant relationships mri based clinical measures conclusion lack group differences could indicate structural connectivity amygdalae volumes anxious depression significantly altered morbid anxiety disorder improving understanding anxiety morbid mdd would facilitate development treatments accurately target underlying networks elsevier ltd rights reserved
study aimed evaluate isoflavone total phenolic contents kefir fermented soymilk storage vitro digestive system simulation dss soymilk fermented kefir culture degrees stored degrees days fermentation storage isoflavone total phenolic contents quantified high performance liquid chromatography spectrophotometry respectively cell viability lactic acid bacteria yeast evaluated fermentation promoted increase approximately log cfu cycles microorganisms storage process alter aglycone isoflavones total phenolic contents content aglycone isoflavones increased fold total phenolic content increased fold therefore kefir fermented soymilk good source aglycone isoflavones phenolics since content substances increased significantly vitro digestive system simulation product elsevier ltd rights reserved
objectives examine extent agreement nursing home residents proxies reports pain presence intensity derived interview questionnaire minimum data set mds nearest interview date design cross sectional comparison data sources pain measurements setting nursing homes included evaluation projects evercare program minnesota senior health options participants nursing home residents grouped based type respondent answering interview questionnaire resident family proxy staff proxy measurements used kappa statistics multinomial logit regression examine agreement interview questionnaire mds pain presence intensity results presence pain reported times often questionnaire depending respondent group agreement presence pain slight fair kappa mds questionnaire slight agreement pain intensity kappa family proxy respondent group showed largest discrepancy questionnaire mds reporting pain presence intensity staff proxy respondent group better agreement pain intensity respondent groups achieved slight agreement kappa conclusions detecting quantifying pain nursing home residents complex pain information best obtained directly residents observations standardized mds revised accordingly
attachment theory promoted impressive body research psychic developmental processes resulting studies typical atypical development much diffusion attachment theory clinical field related design reliable instruments evaluate organization attachment infancy well adulthood recently lack suitable instrument assess attachment middle childhood well adolescence hindered expansion research developmental phases parent child relationship takes different albeit still crucial role child attachment interview cai measure recently designed assess attachment representational level middle childhood adolescence filled measurement gap aim current review summarize previous empirical investigations concerning cai order provide overview state current research identify unanswered questions propose future research directions narrative review conducted map current research findings searching term child attachment interview medline scopus web science psychinfo databases followed search mendeley limits set exclude dissertations chapters books qualitative theoretical papers empirical studies included used cai published english language peer reviewed journals july review ultimately included studies meeting criteria showed cai reliable instrument assess attachment organization clinical non clinical samples thus providing worthwhile contribution investigation influence parent child relationship beyond infancy early childhood nevertheless review pointed number relevant open issues critical concerned cai coding classification system particular relevant questions arose opportune would maintain distinct classification mother father coding challenges regarding father preoccupied disorganized classification finally advantage dimensional categorical approach
transient response model vapor compression refrigeration system developed paper system model contains four sub models representing condenser evaporator compressor electronic expansion valve eev condenser evaporator developed based moving boundary formulation linearization dynamic models transformed state space representation expressed form matrix compressor eev adopt steady models thermal inertia much smaller compared heat exchangers condenser evaporator system model validated experiment terms step change eev opening degree heat load well ramp increase inlet temperature coolant oil condenser results show model simulations good agreement experimental data simulation errors compared experimental data mostly less since model proposed study expressed form state space matrix featured strong portability high computation efficiency allows investigate thermal dynamic characteristics refrigeration system complicated conditions develop excellent control schemes elsevier ltd international institute refrigeration rights reserved
purpose purposes determine contraceptive methods pregnant adolescents intend use postpartum understand factors predispose intention use less effective birth control long acting reversible contraception larc methods participants pregnant minority adolescents prenatal program intention assessed asking following methods preventing pregnancy intend use deliver multinomial logistic regression analysis used determine factors associated intent use nonhormonal contraception male female condoms abstinence withdrawal method short medium acting hormonal smh contraception birth control pill patch vaginal ring injectable medroxyprogesterone acetate compared larc implant intrauterine device postpartum results twenty three percent intended use larc smh method method participants intended use smh contraceptive methods larc significantly likely believe larc effective preventing pregnancy report make decisions help reach goals partners important making contraceptive decisions important factors mother aged years first birth graduated high school experienced prior pregnancy talked parents birth control options perception limited financial resources conclusions distinct profiles factors associated intending use smh contraceptive methods larc postpartum identified may inform future interventions promote use larc prevent repeat pregnancy society adolescent health medicine rights reserved
present embedded system designed enabling telemedicine remote monitoring people progresses physical rehabilitation tasks system consists modular electronics designed interface matrix bendable force sensors piezoresistive piezoelectric assembled flexible pcb implements analog conditioning digital processing sensors readout build pressure map patients activity ksps sampling rate moreover interface integrated microcontroller allows live communication user physician addition standard local logging workout information reduced power consumption live streaming conditions less permits hours autonomy system standard battery supply results demonstrate performance proposed mapping system
eutrophication serious water pollution problem many lakes reservoirs one method understanding causes eutrophication devising strategies address phenomenon watershed modeling integrated model developed paper simulating evaluating water quality protection strategies reservoirs based controlling upstream point non point sources pollution also reservoir operation achieve soil water assessment tool swat model used modeling surface runoff transportation pollutant load watershed area numerical model qual used simulating reservoir water quality models linked simulate transmission distribution water quality variables seimare watershed reservoir system west part iran calibration models different strategies reduction pollution watershed simulated ranked based efficiency reducing pollution load entering reservoir results show completion modernization sewage network wastewater treatment plant kermanshah city long adopting measures direct release municipal wastewater gharehsou river reduce pollution load best short term strategy also found long term period watershed management decreasing local animal husbandry activities effective measure reducing nutrient load entering seimare reservoir thus need considered future watershed management policies programs
first step towards consistent framework individual comparative life cycle assessment lca hydrogen energy systems work performs thorough literature review methodological choices made lca studies energy systems choices affecting lca stages goal scope definition life cycle inventory analysis lci life cycle impact assessment lcia targeted review considers scientific papers published december original case studies hydrogen energy systems found based hydrogen production process case studies classified three technological categories thermochemical electrochemical biological subdivision based scope studies also applied thus distinguishing case studies addressing hydrogen production hydrogen production use mobility hydrogen production use power generation hydrogen energy systems apply cradle gate gate boundaries cradle gate grave boundaries found mainly hydrogen use mobility functional unit usually mass energy based cradle gate gate studies travelled distance cradle gate grave studies multifunctionality addressed mainly system expansion lesser extent physical allocation regarding lci scientific literature life cycle databases main data sources background foreground processes regarding lcia common impact categories evaluated global warming energy consumption ipcc vdi methods respectively remaining indicators often evaluated using cml family methods level agreement trends available hyguide guidelines lca hydrogen energy systems depends specific methodological aspect considered review lca hydrogen energy systems succeeded finding relevant trends methodological choices especially regarding frequent use system expansion secondary data production oriented attributional approaches trends expected facilitate methodological decision making future lca studies hydrogen energy systems furthermore review may provide basis definition methodological framework harmonise lca results hydrogen available far literature
report year old adult case normocytic normochromic regenerative anemia discovered incidentally objectification elliptocytosis accompanied splenomegaly collagen myelofibrosis presence mutation jakvf allowed diagnosis primary myelofibrosis atypical initial presentation causes elliptocytoses discussed
paper effect gas bubbling including slug bubble flows enhancing shear force ultrafiltration process flat sheet module investigated experimentally image processing numerically using openfoam software order study characteristics bubbles slug bubble flows flat sheet module analyzed video system facilitated high speed camera experimental results show average diameter slug flow much larger bubble flow permeate flux slug bubble flows increased respectively compared case gas bubbling numerical results shown good agreement measurements qualitatively quantitatively results simulations also demonstrate although flow patterns increase shear stress increasing velocity gradient vorticity shear stress induced slug flow considerably larger therefore slug flow higher induced shear stress effective enhancement permeate flux process elsevier ltd rights reserved
internal structure asphalt mixture revealed ray computed tomography images provides useful information variety civil engineering applications paper studied two image processing issues commonly encountered asphalt ray images image intensity unevenness caused beam hardening effect unrealistic image segmentation inspired nonuniform illumination correction techniques grayscale morphological method proposed solve image intensity unevenness two modified multilevel thresholding methods developed effectively divide asphalt images three phasesair voids binder aggregates comparisons existing multilevel thresholding methods ones developed study indicate proposed methods provide consistent robust accurate results moreover developed thresholding objective functions enable user easily adjust thresholds match visual examination laboratory test results modifying single parameter developed methods help improve analysis asphalt images various engineering applications american society civil engineers
purpose present study explore degree short term longitudinal change adolescent self regulation attributable maternal parenting mother child relationship quality total mother adolescent dyads provided data waves children national longitudinal survey youth male hispanic african american european american adolescents initial age range years consistent hypotheses longitudinal improvements young adolescents self regulation associated high levels mother child relationship quality low levels maternal discipline association self regulation moderated child sex maternal discipline thus study provides evidence favoring exploration parent child relational context addition discrete parenting behaviors studies self regulation early adolescent years
individuals eating disorders eds often report history early traumatization although great attention paid certain types trauma sexual emotional abuse less known occurrence childhood neglect individuals eds aim present meta analysis provide estimate prevalence childhood emotional neglect physical neglect individuals eds systematic literature search critical appraisal collected studies meta analysis conducted electronic search embase psycinfo pubmed cochrane library inception databases july performed final meta analyzed data set included studies focusing eds eds meta analytic data showed among individuals eds prevalence childhood whereas reported experience childhood preliminary findings confirm high prevalence childhood samples compared general population underline importance systematically screening presence neglect possible traumatic experience individuals eds presence may important consequences therapeutic approach
structural integrity multi component structures usually determined strength durability unions adhesive bonding often chosen welding riveting bolting due reduction stress concentrations reduced weight penalty easy manufacturing amongst issues past decades finite element method fem used simulation strength prediction bonded structures strength materials fracture mechanics based criteria cohesive zone models czms already proved effective tool modelling damage growth surpassing limitations aforementioned techniques despite fact still suffer restriction damage growth predefined growth paths extended finite element method xfem recent improvement fem developed allow growth discontinuities within bulk solids along arbitrary path enriching degrees freedom special displacement functions thus overcoming main restriction czms two techniques tested simulate adhesively bonded single double lap joints comparative evaluation two methods showed capabilities limitations specific purpose elsevier ltd rights reserved
work metal nitride interlayer semiconductor source drain model suggested investigate effect titanium nitride tin tantalum nitride tan specific contact resistivity rho structure sub type finfet work function variation tin tan considered based rayleigh distribution model undoped interlayer undoped heavily doped interlayer included identify effect doping rho structure provides low variation rho well lower rho values similar omega using three dimensional technology computer aided design tcad simulation also investigated impact rho variation device performance showed higher state drive current highly suppressed variation
purpose growing public health concern related rapid increase use multiple tobacco products among adolescents study examined patterns adolescent use cigarettes cigarettes cigars cigarillo hookah waterpipe smokeless dip chewing tobacco population southern california adolescents methods data grade participants southern california children health study collected via self report study participants asked lifetime current past days use cigarettes cigars cigarillos little cigars cigarettes hookah waterpipe smokeless dip chewing tobacco latent class analysis lca used identify patterns tobacco use results hookah waterpipe tobacco use highest current prevalence followed cigarettes prevalence use smokeless dip chewing tobacco lowest adolescents reporting current use lca suggested four distinct classes comprising nonusers sample polytobacco experimenters cigarette hookah users polytobacco users multinomial logistic regression based four classes found males double odds polytobacco users relative nonusers compared females odds ratio confidence interval conclusions identifying naturally occurring configurations tobacco product use teens findings may useful practitioners policymakers identify need tobacco control interventions address specific tobacco products particular combinations polytobacco use lca used identify segments population overrepresented among certain tobacco use classes boys may benefit targeted poly product intervention approaches society adolescent health medicine rights reserved
advent intelligent vehicle technologies holds significant potential alter dynamics traffic flow prior work effects technologies formation self organized traffic jams led analytical solutions numerical simulations mesoscopic scale may yield significant information distribution vehicle cluster size since absence large clusters could offset presence several smaller clusters distribution cluster sizes important presence absence clusters obtain prediction vehicle cluster distribution included work presents statistical mechanics inspired method simulating traffic flow microscopic scale via generalized ising model results microscopic simulations indicate traffic systems dominated adaptive cruise control acc enabled vehicles exhibit higher probability formation moderately sized clusters compared traffic systems dominated human driven vehicles however trend reversed formation large sized clusters qualitative results hold significance algorithm design traffic control easier predict take countermeasures fewer large localized clusters opposed several smaller clusters spread across different locations highway
highway vehicles received level scrutiny highway counterparts relative safety comfort fuel economy automation past decades various active chassis safety control systems architectures schemes researched developed improve stability handling highway vehicles including articulated vehicles tractor trailer applications paper authors investigate yaw stability control system articulated frame steering highway vehicles via novel steer wire technology recently developed high fidelity vehicle dynamics model derived keeping yaw rate decoupled lateral acceleration order separate primary path following task driver secondary disturbance attenuation task controller control algorithm designed two tasks hamper one another automatic controller quickly activated short period time counteract instabilities smoothly relinquishes control back human operator simulation experimental testing results obtained validate vehicle dynamics model control algorithm design new system efficacy counteracting yaw instabilities low friction surfaces using standard vehicle dynamic maneuvers elsevier ltd rights reserved
animal studies led significant advances understanding pain mechanisms intestine could lead altered signaling disorders irritable bowel syndrome however translate human afferent nervous system unclear recent studies demonstrated possible use variety techniques including electrophysiological recordings begin examine concepts humans mini review examines studies explore well animal studies translate humans suffering irritable bowel syndrome highlights advantages technical limitations approaches identifies priorities future studies using human tissues
expanding body research investigated factors influence fathers involvement children generally overlooked role pregnancy intentions men fathering behaviors study authors used nationally representative data men interviewed national survey family growth examine relationships fathers pregnancy intentions multiple aspects parental involvement using propensity score methods control confounding found men less likely live young child mistimed intended pregnancy among nonresident fathers mistimed pregnancies associated lower levels visitation consequently reduced participation caregiving play among resident nonresident fathers mistimed pregnancies also associated lower self appraisals fathering quality compared intended pregnancies nonresident fathers however association moderated involvement
background metformin decreases serum levels monomeric prolactin previous study investigated effect metformin macroprolactin content patients macroprolactinemia methods studied three age sex weight matched groups patients women monomeric prolactin women macroprolactin well women normal prolactin levels coexisting diabetes prediabetes patients treated metformin daily plasma lipids glucose homeostasis markers well serum levels prolactin macroprolactin assessed baseline months metformin treatment results expected metformin reduced plasma glucose triglycerides well improved insulin sensitivity treatment groups moreover drug reduced post polyethylene glycol prolactin levels tended reduce pre polyethylene glycol prolactin levels women monomeric prolactin women macroprolactinemia women normal prolactin levels conclusion obtained results indicate metformin negligible effect macroprolactin levels
golden ring russia considered famous tourist route russia since acts famous umbrella brand also pattern tourism development parts country golden ring sites still keep high tourism recreational attractiveness inbound domestic tourist flows declining last decade route subjected significant changes lead functional spatial transformation article discusses various factors cause changes research methodology based combination systems approach geographical statistical studies spatial construction management research results show original circle route replaced number radial single point routes former multi day tour converted short even single day trips time new tourism attractions new amenities along new forms tourism activities emerge region addition traditional russian historical towns museums innovative tourism clusters appear different parts golden ring area time parts former golden ring route integrated new regional tourism products transformation tourist destinations together changes consumers interests demand notably diversified types tourism golden ring russia formerly route aimed mainly cultural tourism ecotourism leisure family business event types tourism developing necessary differentiate regional tourism destinations working distinct tourism specialization distinguish diversify local tourism brands programs
parkinson disease neurodegenerative disorder characterised loss dopaminergic neurons substantia nigra mutations pink gene result autosomal recessive form early onset pink plays vital role mitochondrial quality control via removal dysfunctional mitochondria aim present study create cellular model using sirna mediated knock pink syy neuroblastoma cells possible protective effects curcumin known many beneficial properties including antioxidant anti inflammatory effects tested model presence absence paraquat additional stressor pink sirna control cells separated four treatment groups untreated treated paraquat iii pre treated curcumin treated paraquat treated curcumin various parameters cellular mitochondrial function measured pink sirna cells exhibited significantly decreased cell viability mitochondrial membrane potential mmp mitochondrial respiration atp production increased apoptosis paraquat treated cells exhibited decreased cell viability increased apoptosis fragmented mitochondrial network decreased mmp curcumin pre treatment followed paraquat exposure rescued cell viability increased mmp mitochondrial respiration control cells significantly decreased apoptosis increased mmp maximal respiration pink sirna cells results highlight protective effect curcumin mitochondrial dysfunction apoptosis pink deficient paraquat exposed cells studies warranted elucidate potential neuroprotective properties curcumin
background harm reduction positive outcomes people using sexual health substance misuse services clinical guidance recommends approaches may appropriately adopted mental health practitioners managing people self harm however little research area methods explored practitioners views harm reduction strategy supporting people self harm self harm antipathy scale shas administered random sample mental health practitioners working wards england semi structured interviews conducted survey respondents results practitioners implemented approach reported positive outcomes including reduction incidence severity self harm perceived increase empowerment service users practitioners experience using harm reduction concerned self harm would increase severity unsure assess manage risk people harm reduction care plan fundamentally disagreed principle harm reduction self harm challenged core beliefs morality self harm ethical potential legal ramifications allowing individuals harm limitations study conducted solely practitioners working inpatient units majority staff interviewed experience harm reduction concerns may reflect challenges encountered practitioners clinical practice conclusions harm reduction used support people self harm within inpatient psychiatry practitioners report potential benefits approach however raises particularly complex practical ethical legal issues research needed assess safety acceptability efficacy approach
objectives explore whether serum urinary advanced glycation end products ages related urinary symptoms bladder dysfunctions diabetic patients methods forty seven patients type diabetes mellitus tdm lower urinary tract symptoms luts enrolled luts evaluation performed ipss international prostatic symptoms score qol quality life oab overactive bladder ici international consultation incontinence short form quaestionneires ultrasound examination evaluation postvoid residual pvr uroflowmetry cystometry pressure flow study pfs performed detect bladder dysfunctions serum urinary ages quantified elisa method results patients divided four subgroups normal detrusor contractility normal detrusor activity impaired detrusor contractility normal detrusor activity iii normal detrusor contractility detrusor overactivity impaired detrusorcontractility detrusor overactivity serum ages men women urinary ages men women serum ages exhibited positive correlation ipss oab scores increased serum ages associated significant reduction parameters reflecting impaired detrusor contractility simultaneous reductions urinary ages greater correlation observed serum ages subgroup conclusions serum ages seem early markers diabetic complications appear related luts bladder dysfunctions
objective describe epidemiology illness sochi winter paralympic games methods total athletes countries monitored daily days sochi winter paralympic games athlete days illness data obtained daily teams without medical support teams athletes teams medical support teams athletes electronic data capturing systems results total number illnesses reported illness incidence rate per athlete days highest reported wheelchair curling illnesses respiratory system eye adnexa digestive system common older athletes years significantly higher younger athletes years conclusions results study indicate paralympic athletes report higher illness incidence rates compared olympic athletes similar competitions highest rates illness reported respiratory digestive systems eye adnexa respectively thus results study form basis identification physiological systems higher risk illness turn inform illness prevention management programmes eventual policy change promote athlete safety future editions winter paralympic games
prolonged internet video game play may multiple complex effects human cognition brain development negative positive ways currently consensus principle effects video game play neither brain development relationship psychiatric comorbidity study adolescents internet gaming disorder igd comparison subjects without igd including subgroups psychiatric comorbid disease major depressive disorder attention deficit hyperactivity disorder adhd included resting state functional magnetic resonance imaging analysis severity internet gaming disorder depression anxiety adhd symptoms assessed young internet addiction scale beck depression inventory beck anxiety inventory korean adhd rating scales respectively patients igd showed increased functional correlation seven pairs regions satisfying false discovery rates light multiple statistical tests left frontal eye field dorsal anterior cingulate left frontal eye field right anterior insula left dorsolateral prefrontal cortex dlpfc left temporoparietal junction tpj right dlpfc right tpj right auditory cortex right motor cortex right auditory cortex supplementary motor area right auditory cortex dorsal anterior cingulate findings may represent training effect extended game play suggest risk predisposition game players connectivity default mode executive control networks may relate psychiatric comorbidity
existing building energy optimization workshop aims provide resilient energy optimization solutions existing buildings stakeholders paper introduces recently developed existing building energy optimization workflow laser building scanning bimbem added order increase productivity time consuming labor intensive conventional energy optimization processes existing buildings paper also demonstrates model calibration suggests feasible ecms exemplary building author intent share lessons workshop use ict tools accelerate active collaboration building service engineers non experts eventually workshop workflow lessons used formulate educational curriculum green building design retrofit classes lastly paper enclosed future research initiatives developing enhanced process harness toward analysis driven retrofit decision making value initiatives found increasing usability formalized expertise appropriate localizations
background costimulatory blockade lymphocytes ctla fusion protein abatacept could effective treatment immune mediated neuroinflammatory disease relapsing remitting multiple sclerosis rrms objective evaluate efficacy safety abatacept rrms methods acclaim cooperative clinical study abatacept multiple sclerosis phase randomized double blind placebo controlled multi center trial planned participants rrms randomized monthly intravenous infusions abatacept placebo weeks ratio switched opposite treatment weeks received final dose study medication weeks enrollment closed early due slow accrual primary endpoint mean number new gadolinium enhancing lesions obtained magnetic resonance imaging mri scans performed every weeks results statistically significant differences observed mean number new mri lesions abatacept placebo groups statistically significant differences observed mri clinical parameters rrms disease activity abatacept well tolerated conclusion acclaim study demonstrate efficacy abatacept reducing number new mri lesions clinical measures disease activity rrms
rainwater harvesting rwh traditionally implemented areas semi arid climates limited access potable water supplies however recent droughts humid southeastern united states led increased implementation rwh systems objectives study twofold present usage characteristics performance results four rwh systems installed humid north carolina compared systems located arid semiarid regions identify system benefits modifications could help improve performance rwh systems installed humid regions world study four rwh systems installed usage monitored least one year compared similar studies results revealed dedicated water uses usage characteristics rwh systems differed previously reported literature two systems studied met potable water demand designated uses animal kennel flushing greenhouse irrigation respectively designated uses yielding greatest potable water replacement often seasonal periodic thus necessitating need identifying implementing secondary objectives systems namely stormwater management otherwise expense effort required implement rwh systems humid areas likely preclude use
child parent violence cpv involves continual cumulative abusive actions perpetrated children adolescents towards parents caregivers abuse produces short term distress ongoing long term harmful consequences parents families practitioners researchers policy makers increasingly challenged identify conceptualize respond form family violence major challenge parents caregivers report abuse lack awareness understanding psychological experiences relation cpv research adopts interpretative phenomenological approach explore psychological experience cpv interviews conducted six new zealand mothers two grandmothers experienced cpv abuse experienced emotional bloody roller coaster unconditional love hatred judgement self blame others blame parenting skills absent father adolescents lives drawn explanation abuse taken together psychological experiences identify silencing cpv related parents conflicting emotions towards children thoughts feelings people view impact absent father figure children everyday lives
present key arguments knowledge translation requires tacit explicit knowledge must introduced organization well simply acquired individuals educating knowledge translation must beyond conveying facts developing capability constructivist collaborative approach education address needs learners knowledge translation online environment appropriately used many useful features supporting constructivist collaborative learning illustrate arguments reference part time online master science course whose learners mostly senior health care professionals engaged knowledge translation
structure damage normally exhibits nonlinear dynamic behaviors time dependent stiffness damping estimating instantaneous dynamic characteristics structures generally useful assessing structural damage real application study presents novel effective approach accurately estimating instantaneous dynamic characteristic structure using time varying autoregressive exogenous tvarx model gabor frame evaluate time varying coefficient matrices time series model proposed procedure applies gaussian based weighted function fourier transform time series model gabor transform based time series formula could obtained dynamic characteristics structure determined coefficient matrices numerical analyses demonstrate proposed approach superior traditional time frequency analysis accurately estimating instantaneous dynamic characteristics structure finally proposed approach applied process measured data steel frame specimen subjected series base excitations shaking table tests
research analyses emotional competence difficulties measured emotional intelligence empathy social communication disorders young victims abuse minors residential care centres protective measures suffering maltreatment neglect relation emotional competence social communication analysed well contribution empathy emotional intelligence predicting social communication results indicate lack emotional competence related predict difficulties social communication study manifests scarcity emotional intelligence affecting attention emotional repair clarity feelings well deterioration affective cognitive empathy minors scarce ability put place others understand others intentions emotional states limits use language social interactions research stresses need set intervention programmes aimed training interpersonal intrapersonal emotional competences encourage social communication
purpose share experience open reduction single screw internal fixation delayed bilateral condylar head fractures fragmentation evaluate feasibility outcomes patients methods study involved males female patients multiple injuries different body sites failed non surgical treatment bilateral condylar head fractures mean period injury operation weeks according preoperative computer aided design clinical manifestations fracture fragments reduced fixed single screw helical scan requested postoperatively check reduction fragments location screws mean follow duration months result malocclusion corrected operation intraoperative passive mouth opening mouth opening months follow transverse fingers last follow one progressive limitation mouth opening months follow conclusions strategy open reduction single screw internal fixation bilateral condylar head fracture fragmentation mandible feasible effective treatment option rare delayed cases failed non surgical treatment european association cranio maxillo facial surgery published elsevier ltd rights reserved
finding developing inhibitors catechol methyltransferase comt natural products highly recommended daphnetin naturally occurring catechol family thymelaeaceae chemical structure similar several potent comt inhibitors reported previously potential daphnetin phase metabolites inhibitors comt investigated human liver cytosol hlc daphnetin methylated metabolite methyldaphnetin found inhibit comt mediated dopamine methylation dose dependent manner values daphnetin similar methyldaphnetin similar little affected changes hlc concentrations kinetic analysis showed differences inhibition type parameters daphnetin competitive methyldaphnetin noncompetitive metabolites including glucuronidated sulfated species showed negligible inhibition comt using vitro vivo extrapolation ive fold increase exposure comt substrates predicted administrated daphnetin high comt inhibiting activity daphnetin could serve lead compound design development new comt inhibitors also much attention paid clinical impact combination daphnetin herbal preparations containing daphnetin drugs primarily cleared comt
paper propose non cooperative differential game theory based resource allocation approach network security risk assessment risk assessment resource used risk assess including response cost response negative cost whole assessment process considered differential game optimal resource control proposed scheme obtained nash equilibrium proved game theory based algorithm applicable optimal resource level achieved based proposed algorithm
background repeated use postcoital hormonal contraception currently recommended due higher risk side effects lower contraceptive effectiveness compared modern methods contraception however emerging evidence indicates renewed interest regular coitally dependent method oral contraception evaluated existing data safety effectiveness pericoital use levonorgestrel hormonal drugs prevent pregnancy objectives determine effectiveness safety repeated use pre postcoital hormonal contraception pregnancy prevention search methods searched september trials tested repeated pre postcoital use hormonal drugs pregnancy prevention databases included central medline popline searched current trials via clinicaltrials gov ictrp initial review also searched embase cinahl lilacs wrote researchers identify trials selection criteria considered published unpublished studies repeated postcoital immediately precoital use hormonal drugs contraception pregnancy outcome data collection analysis two authors independently confirmed eligibility extracted data included studies calculated confidence intervals around individual study pearl indices using poisson distribution presented individual study estimates pooled estimates appropriate main results found trials evaluated pericoital use lng hormonal drugs regular basis prevent pregnancy studies included total participants conducted europe asia americas drugs doses evaluated included levonorgestrel lng studies lng doses trials hormones lng trials outcomes included pregnancy rates discontinuation side effects acceptability pericoital levonorgestrel reasonably efficacious safe pooled pearl index dose lng per woman years pooled pearl index doses lng per woman years hormonal drugs appeared promising studied extensively menstrual irregularities common side effects reported however studies provided consistent evidence relationship bleeding abnormalities either frequency pill intake total dose drug non menstrual side effects reportedly mild tabulated studies women liked pericoital method spite frequent menstrual irregularities authors conclusions studies pericoital lng regimens provided promising results many serious methodological issues reports decades old provided limited information however considered evidence moderate quality large number participants diverse populations low pregnancy rates consistent results across studies rigorous research still needed confirm efficacy safety pericoital use lng primary means contraception among women infrequent intercourse method shown efficacious safe acceptable results may warrant revision current world health organization recommendations marketing strategies
triangle method frequently used regional evapotranspiration evaporative fraction estimation using relationship vegetation index surface temperature simple histogram based orbit estimation algorithm developed determine hot cold edges triangle distribution using remotely sensed data new histogram based estimation algorithm developed compared different options existing hot cold edge algorithms selected algorithms applied year terra modis data products orbit estimations validated using ground truth data southern great plains using numerous iterations among tested algorithms triangle method histogram based hot edge newly proposed cold edge algorithm combinations provide excellent performance ground truth orbit estimations shown histogram based algorithm enhanced correlation mean bias values respectively providing excellent accuracy regional orbit estimations society photo optical instrumentation engineers spie
active iodide transport thyroid extrathyroidal tissues mediated symporter nis thyroid nis mediated uptake plays pivotal role thyroid hormone biosynthesis ths key embryonic postembryonic development critical cell metabolism stages life molecular characterization nis use radioactive isotopes led significant advances diagnosis treatment thyroid cancer provide molecular basis studies aimed extending use radioiodide treatment extrathyroidal malignancies review focuses recent findings homeostasis transport deficiency causing nis mutations well current knowledge structure function properties nis nis regulatory mechanisms also discuss employing nis reporter gene using viral vectors stem cells imaging diagnostic therapeutic procedures
olfactory system represents one suitable models study interactions peripheral central nervous systems developing olfactory epithelium olfactory placode pit gives rise several cell populations migrate towards telencephalic vesicle one cell populations called migratory mass accompanies first emerging olfactory axons olfactory placode fate cells contribution olfactory bulb populations properly addressed asses issue performed ultrasound guided utero retroviral injections embryonic day revealing early source olfactory ensheathing cells later postnatal stages employing wide number antibodies identify nature infected cells described cells generated within belong different cell populations mesenchyma envelop olfactory axons express common glial markers olfactory bulb restricted olfactory nerve glomerular layers thus data reveal existence novel progenitor class within potentially derived olfactory placode gives rise different neural cell population including cns neurons glia olfactory ensheathing cells wiley liss inc
cellular senescence implicated diverse pathologies however conflicting evidence regarding role process tissue fibrosis although dysregulation micrornas key mechanism pathogenesis lung fibrosis unclear whether micrornas function regulating cellular senescence disease study found mir demonstrated greater expression lungs patients idiopathic pulmonary fibrosis mice experimental pulmonary fibrosis primary localization lung fibroblasts importantly mir regulated significantly human mouse lung myofibroblasts found mice mir ablation developed severe pulmonary fibrosis wild type animals fibrotic lung injury mechanistically found mir induced senescent phenotype lung fibroblasts microrna increased senescence associated beta galactosidase activity enhanced expression senescence markers decreased cell proliferative capacities consistently found primary lung fibroblasts fibrotic lungs mir deficient mice diminished senescent phenotype enhanced resistance apoptosis compared wild type animals also identified multiple mir targets likely mediated activities inducing senescence lung fibroblasts conclusion data suggest mir functions negative feedback mechanism restrain fibrotic response lungs promoting senescence pulmonary fibroblasts
dysregulation mitogen activated protein kinase mapk pathway costello syndrome may contribute increased risk autism spectrum disorder asd examined prevalence asd symptoms individuals six females age years molecularly confirmed caregivers completed modified checklist autism toddlers chat ages years social communication questionnaire scq ages older age associated meeting asd criteria younger children met asd cut mchat compared older children scq following medical developmental factors strongly associated asd criteria chat gastrostomy tube time assessment eating solid food walking toilet trained two children met stricter asd criteria significantly lower adaptive functioning physically much impaired among older participants scq subscale scores communication socialization repetitive behavior domains comparable typically developing normative sample asd symptoms highly elevated younger individuals older children differ typically developing samples prevalence asd symptoms individuals may appear fall autism spectrum early childhood due severe feeding orthopedic problems improve age four suggesting many children may eventually emerge asd presentation
forward scattering radars fsrs acquire great interest low radar cross section rcs targets willing detected type radar provides countermeasure stealth technology targets rcs depends size shape silhouette passive radars use transmitters opportunity signal source therefore attractive due inherit low cost advantage considering global navigation satellite system gnss satellites transmitters opportunity high availability satellites offer anywhere earth around eight global positioning system gps satellites continuously view due large number new gnss satellites becoming operational near future american gps russian glonass european galileo system chinese compass satellites expected constantly view provides optimum scenario implementation gnss fsr system paper experimental results gps fsr different target receiver scenarios near nuremberg airport analyzed disturbances signals due diffraction effects take place targets cross receiver satellite baselines discussed evaluated experiments hemispherical antenna used provides promising results future gnss fsr implementation
background preoperative nutritional status physical function important predictors mortality morbidity cardiac surgery however influence nutritional status cardiac surgery physical function progress postoperative rehabilitation requires clarification aims determine effect preoperative nutritional status preoperative physical function progress rehabilitation elective cardiac surgery methods enrolled elderly patients mean age years undergoing cardiac surgery divided two groups nutritional status measured geriatric nutritional risk index gnri high gnri group gnri low gnri group gnri physical function estimated handgrip strength knee extensor muscle strength kems short physical performance battery sppb minute walk test mwt progress postoperative rehabilitation evaluated number days independent walking surgery length stay icu length hospital stay results adjusting potential confounding factors preoperative handgrip strength kems sppb mwt significantly better high gnri group multiple regression analysis revealed low gnri independent predictor retardation postoperative rehabilitation conclusions preoperative nutritional status assessed gnri could reflect perioperative physical function preoperative poor nutritional status may independent predictor retardation postoperative rehabilitation patients undergoing elective cardiac surgery
bedtime problems frequent night wakings common sleep problems infants toddlers affecting young children problems categorized behavioral insomnia childhood bic lead insufficient sleep contributes multiple domains child dysfunction behavioral treatments bic extinction positive routines introduced supporting evidence reviewed critical factors developing successful treatment plan include conducting detailed assessment collaboratively developing plan starts family providing support sessions case year old girl bic illustrates treatment helped develop healthy sleep habits taught sleep independently via graduated standard extinction wiley periodicals inc clin psychol session
frameworks environmental regulations fundamental yet problematic factors achieving climate mitigation adaptation policy goals recent theoretical arguments claim value general legal frameworks enable experimentation contextual adaptation policies however empirical research regarding effects general specific norms practice urban intervention remains limited article empirically discern city governments deal tension control flexibility implementation urban climate change goals argue policies adaptation mitigation face two types implementation problems non adaptive implementation non implementation first stems excessively constraining use rules second derives general undefined regulatory framework analysing two empirical cases amsterdam netherlands boston usa conclude three elements affect way actors deal deficits level scale regulations established degree land ownership provides margin manoeuvre public authorities sense political urgency behind mitigation adaptation
article author presents case chose accept patient facebook friend request describes early model scene lichtenberg shaped patient sense self relationships similar interpersonal dynamic recreated analytic dyad treatment progressed analyst found necessary revisit reconceptualize idea traditional psychoanalytic frame better meet patient developmental selfobject relational needs author elaborates frame changed expansion frame deepened analyst patient bond ways use social media opened new therapeutic opportunities relational possibilities treatment author discusses case illustrates bacal bacal herzog theories optimal responsiveness specificity addresses related topics include implicit mode relatedness nonverbal communication analyst self disclosure self consciousness
paper evaluates biological regeneration ferric solution desulphurisation gaseous streams hydrogen sulphide absorbed aqueous ferric sulphate solution oxidised elemental sulphur ferric ions reduced ferrous ions industrial regeneration nutrients trace minerals usually provided laboratory setup present depletion nutrients may negative impact bacteria responsible ferrous iron oxidation may probably affect oxidation rate study effect nutrients trace minerals ferrous iron oxidation investigated results showed presence nutrients trace minerals affects efficiency bacterial oxidation scanning electron microscopy analysis geotextile support material also conducted results showed iron precipitate deposits appear play direct role bacterial biofilm formation
aim study determine whether participating cross country skiing stage race tour ski tds affects subsequent illness incidence training race performance self reported training illness data male female elite cross country skiers included total years data collected seasons per athlete illness incidence training load performance international competitions calculated athletes participate tds forty eight percent athletes reported becoming ill days immediately taking part tds athletes participate groups illness incidence somewhat lower female athletes male athletes race performance significantly worse weeks following tds weeks tds furthermore female athletes participated tds performed relatively better controls olympics world championships male athletes participated tds typically performed worse subsequent major championships participating tds appears result approximate fold increase risk illness period male athletes appear prone illness also see drop race performance following tds possibly linked differences training load event
study prepared multi functional thin film thermoelectric device small scale energy harvesting self powered light sensing comprehensive optimization conducted terms thermoelectric material device system integration thermoelectric thin films device prepared using sputtering method together post annealing process fresnel lens incorporated thin film thermoelectric device energy concentration addition simulation procedure used facilitate optimization heat sink provide fast heat dissipation mechanical support thin film thermoelectric device electricity generation light sensing performance characterized solar irradiation followed feasibility study sensor application results indicate thin film thermoelectric device exhibits high voltage output greatly enhanced responsivity work presents significant progress toward integrated design applicable multifunctional thin film thermoelectric sensor detecting sunlight intensity
osteoarthritis inflammatory disorder dealing focal degradation articular cartilage oxidative stress inflammation major events present study aimed identifying mechanism potent antioxidant plumbagin protecting hydrogen peroxide induced chondrocyte oxidative stress inflammatory signaling oxidative stress determined measuring reactive oxygen species lipid peroxidation non enzymic glutathione gsh enzymic antioxidant activities gsh glutathione transferase glutathione peroxidase superoxide dismutase catalase expression levels nuclear factor erythroid derived like nrf heme oxygenase nad quinone oxidoreductase nqo nuclear factor kappa kappa cyclooxygenase cox inducible synthase inos determined western blot analysis pro inflammatory cytokine expression levels assessed using elisa results reactive oxygen species generation lipid peroxidation content antioxidant enzyme activities demonstrated plumbagin significantly inhibited oxidative stress status induced chondrocytes addition plumbagin modulated transcription factors involved redox inflammation regulation including kappa nrf nuclear expression plumbagin enhanced antioxidant status increasing expression levels nrf target genes including nqo anti inflammatory effect chondrocyte induced inflammation demonstrated downregulating cox inos pro inflammatory cytokine expression levels tumor necrosis factor alpha interleukin present study identified strong evidence protective role plumbagin induced oxidative stress inflammation chondrocytes modulating redox signaling transcription factors
background experience sensed presence feeling sense another entity individual present despite clear sensory perceptual evidence known occur general population appears frequently religious spiritual contexts seems prominent certain psychiatric neurological conditions may reflect specific functions social cognition body image representation systems brain previous research relied hoc measures experience specific psychometric scale measure experience exists date methods based phenomenological description literature created item sensed presence questionnaire senpq recruited participants general population sample sample including specific selection religious affiliation complete senpq additional measures well schizotypy social anxiety social imagery spiritual experience completed analysis test internal reliability ability senpq distinguish religious non religious participants whether senpq specifically related positive schizotypical experiences social imagery factor analysis also conducted examine underlying latent variables results senpq found reliable valid religious participants significantly endorsing items non religious participants scale showing selective relationship construct relevant measures principal components analysis indicates two potential underlying factors interpreted reflecting benign malign ensed presence experiences discussion senpq appears reliable valid measure sensed presence experience although validation neurological psychiatric conditions warranted
agricultural intensification led use high inputs chemical fertilizers rice cultivated lands nitrogen heavy metals runoff loss land major environmental problem important mitigate nitrogen heavy metal pollution water body nitrogen heavy metal transformation rice field surface water studied applied combined organic inorganic nitrogen fertilizer plus nitrification inhibitor dimethylpyrazole phosphate dmpp sandy loam paddy soil blue clayey paddy soil results showed application dmpp rice field organic inorganic fertilizer combined application models decreased heavy metal average concentration total surface water respectively furthermore sandy loam paddy soil blue clayey paddy soil nitrate nitrite total inorganic nitrogen concentrations decreased rice field surface water dmpp addition organic inorganic fertilizer combined application models rice field respectively dmpp could used effective nitrification inhibitor decline potential nitrogen heavy metals runoff loss combined application models organic inorganic fertilizers rice fields minimizing nitrogen heavy metal transformation risk agricultural fields water body beneficial protecting ecological environment
microcontroller modules introduced life test system apply stimuli stress patterns unit test firmware must evaluate status operational function tested device multitude different applications finite state machine design microcontroller presented configurable via communication bus controller acts according given test plan description various sources trigger events cause transition state machine custom lua script code executed state order control communicate test hardware
paper provides fundamentals integrated motor drive system design knowledge could used basis change existing machine design approach separate machine design tool advanced engineering package various user preferences including motor performances transient rated flux weakening operations along inverter quality studied means competent simulation process utilizes fem matiab simulink packages build framework based magnetic electric electronic devices quantities modeled simulated post processed case study interior permanent magnet motor connected field oriented controlled drive investigated design process concepts developed means comprehensive statistical analysis initial goal reduce search space optimal region shown incorporating inverter effects design process changes idea optimum motor design design parameters also expectations motor performance revised fact integrated motor drive system design process regarding best motor operations transient rated flux weakening modes targeted ultimate goal set practical solutions proposed fulfill motor operations requirement keeping inverter efficiency highest possible level
objective objective assess risk pelvic inflammatory disease among women current asymptomatic undiagnosed cervical infection high risk sexually transmitted infections stis comparing copper bearing levonorgestrel lng intrauterine device iud placed women study design searched pubmed cochrane library articles january january addressing objective assessed study quality using united states preventive services task force evidence grading system results search strategy yielded articles met inclusion criteria two studies provided direct evidence rates women undiagnosed gonococcal chlamydial infection high risk stis initiating iuds versus contraceptive methods level fair poor neither study found difference eight studies provided indirect evidence fair poor one study found difference pid rates initiators versus lng iuds five studies compared algorithms based patient factors laboratory screening predict cervical infection based likelihood ratios none algorithms adequately identified women high risk asymptomatic cervical infection undergo iud placement two studies compared iud placement day sti screening delayed placement screening found difference rates conclusion limited evidence suggests iud placement increase risk pid compared iud placement among women asymptomatic undiagnosed cervical infection high risk stis algorithms based patient characteristics identify women asymptomatic may overly restrictive leading missed opportunities iud initiation historical concerns higher pid risk among women risk stis use iuds may relevant modern devices sti screening treatment practices published elsevier inc
theory chaos chaotic neural networks cnns widely investigated past two decades however researchers area merely focused make full use cnns solve various problems areas pattern recognition classification associate memory cryptography philosophy design cnn seldom discussed paper present general methodology designing cnns appropriately choosing self feedback mechanism also including coupling functions external stimulus succeeded proving dynamical system defined discrete time feedback equations indeed possess interesting chaotic properties best knowledge results presented novel pioneering
objective treatment guidelines published world wide highlighted concerns increased metabolic risks associated second generation antipsychotics sgas aim study evaluate blood glucose monitoring rates sga new users older people aged years study period investigate pre post best practice advocacy centre bpac glucose monitoring recommendation new zealand methods study population based retrospective cohort sga new users days without pre exposure antipsychotics pharmaceutical collections data extracted used identify older people dispensed sgas linked national minimum dataset laboratory claims collection methodology anatomical therapeutic chemical method classification used characterise sgas dispensed results new users dispensed sgas received glycaemic control monitoring least study period monitored baseline monitored glycaemic control within first days glycaemic control monitoring within first days increased half sga new users proportion individuals monitored independent chi pre post bpac recommendation conclusions blood glucose monitoring underutilized new sga users significant improvement glycaemic control monitoring observed bpac consensus statement release baseline days days prescribers must cautioned metabolic risks posed sgas recommend glycaemic control monitoring elsevier rights reserved
background chronic antigen exposure ageing increases frequency box expressed cells bet expressing lymphocytes mice frequency significance cell bet expression chronic hepatitis hcv infection human subjects never described methods healthy controls cirrhotic noncirrhotic hcv infected patients non hcv patients cirrhosis recruited peripheral blood mononuclear cells phenotyped expression bet related markers flow cytometry subset patients underwent antiviral therapy cured hcv infection sustained virological response dynamics bet expression cells monitored cure convalescent cells tested bet expression exposure infected plasma recombinant hcv proteins results forty nine patients including healthy donors hepatitis infected individuals nine liver cancer cirrhosis eight without cirrhosis eight patients cirrhosis due non hcv related cause recruited found cells patients chronic hcv exhibited increased frequency bet cells relative noninfected individuals median significant differences noncirrhotic cirrhotic cancer bearing infected individuals bet cells expressed higher levels cxcr cdc fcrl compared bet cells predominantly exhibit tissue like memory phenotype independent hcv infection bet cells hcv infected patients frequently class switched igd igg resolution hcv infection direct acting antiviral daa therapy leads marked reduction frequency bet cells median pretreatment end treatment svr exposure convalescent cured cells viremic plasma recombinant hcv protein led expression bet conclusion chronic antigenemia chronic hcv infection induces maintains antigen specific bet cell cells share markers tissue like memory cells antigen driven bet expression may critical suppressor cell activation chronic hcv infection
due part gender roles socialization caretakers women health service psychology hsp programs may vulnerable experiencing stressful events negatively impact professional academic functioning two constructs particularly germane understanding stress experienced women hsp programs quality life self care however scant literature exists women hsp programs especially concerning relations among stress self care quality life purpose study address conceptual methodological deficiencies literature empirically testing application health promotion model women hsp doctoral programs investigation tested extent self care activities moderated negative association stress quality life sample women enrolled hsp programs throughout united states salient findings women hsp programs compared populations evidenced substantively higher stress levels lower self care overall stress uniquely inversely though modestly related whereas self care moderating effects self care quality life best conceptualized analyzed multidimensional constructs findings suggest stress levels may significantly larger effect self care women hsp doctoral programs results also suggest self care multidimensional constructs need analyzed implications theory practice research discussed
science computing platforms changing traditional premises computing platforms clouds style research publications also changing movement open science example common researchers bioscience research community publish research papers associated research data internet furthermore demands reproducibility computational experiments increasing conventional method sharing source codes application programs enough guarantee reproducibility computational experiments paper propose overlay cloud architecture building virtual clouds cloud platforms proposed architecture middle ware virtual cloud provider vcp automatically configures computing environments application programs operating systems libraries binaries required reproduce computing results using linux container technology vcp also deploys containers computing environments clouds configures overlay network connecting deployed containers case study considers dna sequencing software shows vcp deployed used reproduce results
functional outcome schizophrenia heterogeneous markers course missing functional outcome associated social cognition negative symptoms gesture performance nonverbal social perception critically impaired schizophrenia tested whether gesture performance nonverbal social perception could predict functional outcome ability adequately perform relevant skills everyday function functional capacity months naturalistic longitudinal study patients schizophrenia completed tests nonverbal communication baseline follow addition functional outcome social occupational functioning well functional capacity follow assessed gesture performance nonverbal social perception baseline predicted negative symptoms functional outcome functional capacity month follow gesture performance predicted functional outcome beyond baseline measure functioning patients gesture deficits baseline stable negative symptoms experienced decline social functioning patients without gesture deficits negative symptom severity decreased social functioning remained stable thus simple test hand gesture performance baseline may indicate favorable outcomes short term follow results support importance nonverbal communication skills subjects schizophrenia
cannabinoid mediated memory impairment concern cannabinoid based therapies caffeine exacerbates cannabinoid receptor cbr induced memory deficits adenosine receptor mediated mechanism evaluated chronic acute blockade adenosine receptors affects long term episodic memory deficits induced single injection selective cbr agonist long term episodic memory assessed novel object recognition test mice received intraperitoneal injection receptor agonist win immediately training tested novelty recognition later anxiety levels assessed elevated plus maze test immediately mice also tested exploratory behaviour open field chronic blockade istradefylline day administered orally days acute blockade aars assessed injection sch administered either together win min test phase involvement assessed using cbr antagonist win caused disruption action absent mice also receiving sch encoding consolidation phase sch ineffective present retrieval effects detected elevated plus maze open field test finding cbr mediated memory disruption prevented antagonism adenosine highlights possibility prevent cognitive side effects therapeutic application cbr drugs desired elsevier ltd rights reserved
research begun explore relationship cancer child abuse thus far work shown child abuse associated higher odds cancer adulthood unfortunately current research plagued three interrelated issues agreement actions constitute abuse abuse types physical sexual emotional abuse distinct interrelated analytic strategies limit types conclusions drawn treat measure abuse related concepts theories exist explain connection abuse cancer issues implications described integrated theoretical framework attempts address current shortcomings proposed going forward abuse research carefully consider measures mechanisms linking abuse disease order test meaningful hypotheses advance theoretical understanding connections
background bright light therapy blt well established treatment seasonal depression last two decades interest blt expanded involve nonseasonal types depression role blt nonseasonal depression remains unsettled view growing number studies area review aimed assess efficacy blt nonseasonal depression methods searched pubmed scopus psychinfo evidence based medicine guidelines cochrane library december standardized mean difference calculated assess efficacy blt nonseasonal depression data subgrouped according different study characteristics heterogeneity assessed examining index results nine trials met inclusion criteria employing conservative random effects model overall model showed significant reduction depressive symptoms blt administration smd particular blt appears efficacious administered weeks smd monotherapy smd limitations overall heterogeneity included trials moderate participants adequately blinded intervention sample size small certain subgroups long term effect blt depression explored conclusions blt appears efficacious particularly administered weeks duration monotherapy obvious need optimize duration intensity exposure timing duration treatment sessions elsevier rights reserved
common finding source monitoring literature greater similarity impairs source discriminability experiments traditionally manipulate similarity overtly describing showing sources explicitly differentiable features however people may also infer source characteristics also affect discriminability two studies examined inferred source characteristics capitalizing group homogeneity effect whereby group members conceptualized diverse group members participants learned two sources described members group group whose actions higher priori association either group source memory superior participants believed sources group members demonstrates people spontaneously include inferred features source representations capitalize features source monitoring interestingly information suggesting membership one group improved performance even sources previously considered group members experiment
large number studies investigating various biomarkers allergy published past decades aim review evaluate biomarkers diagnostic predictive value date single specific biomarker allergy identified allergy one disease collection number allergic conditions plausible combination clinical history clinical readouts diagnostic markers needed
current study measured adults erps interacted character virtual reality paradigm participants believed character controlled human avatar condition others believed controlled computer program agent condition trial participants initiated joint attention order direct character gaze toward target trials character gazed toward target congruent responses trials character gazed different location incongruent response avatar condition character incongruent gaze responses generated significantly larger peaks centro parietal sites congruent gaze responses agent condition effect strikingly absent left occipitotemporal responses significantly smaller agent condition compared avatar condition congruent incongruent gaze shifts data suggest beliefs human agency may recruit mechanisms discriminate social outcome gaze shift approximately mechanisms may modulate early perceptual processing gaze findings also suggest ecologically valid measurement social cognition may depend upon paradigms simulate genuine social interactions
background majority parkinson disease cases sporadic idiopathic suggesting neurodegenerative disorder result environmental genetic factors stress neuroinflammation among factors investigated possible contributions experiments rodents showed severe chronic stress reduce number dopaminergic neurons substantia nigra pars compacta snc cells lost actions least part mediated increased oxidative stress tested hypothesis interleukin receptor alpha cytokine receptor whose activation increases vulnerability dopaminergic neurons oxidative damage participates stress dependent damage neurons methods mice subject daily sessions acute stress weeks days week procedure previously showed induce loss dopaminergic neurons snc source kinetics interleukin endogenous ligand evaluated weeks stress identification producing cell type performed immunofluorescent situ hybridization experiments markers oxidative stress microglia activation number dopaminergic neurons knock animals iira wild type littermates iira evaluated weeks stress weeks following week nonstressed period compared non stressed mice results expressed microglial cells within fraction tyrosine hydroxylase positive neurons snc levels elevated daily stress peaked weeks chronic restraint stress significantly reduced number snc dopaminergic neurons iira mice neuronal loss weeks significantly lower iira mice however loss dopaminergic neurons measured weeks weeks non stress following weeks stress similar iira ilray mice conclusions cytokine previously demonstrated increase susceptibility snc dopaminergic neurons oxidative stress elevated restraint stress lack prevent halted delayed neuronal loss mouse model chronic restraint stress may represent target reduce rate neuronal loss occur severe chronic restraint stress
data structure course important basic course computer programming problems exist teaching process extent affected teaching effect course perspective teaching practice paper puts forward data structure course teaching existing problems put forward solve problems based cdio teaching reform scheme explore face appeared course variety teaching situation whether timely captured data architecture detailed reform explore cdio data architecture organic integration classroom answer students learning life bring certain degree activity open lay solid foundation thinking
ambient assisted living technologies could support people experiencing physical cognitive challenges maintain social identities complex activities daily living although substantial investment developing ambient assisted living innovation less effort devoted understanding evaluate impact ambient assisted living physical mental health taking theory based evaluation approach suggest firstly ambient assisted living technologies rely networks people organizations function secondly analysing changing structure networks bridge gap socio technological change individual level capabilities present conceptual arguments taking network perspective ambient assisted living evaluations illustrated examples group work technology use among older people cognitive impairments discuss different types network based evaluation approaches available theoretical assumptions sort research questions could address
innovative blended learning strategy presented subject laboratory elasticity strength materials based use different tools combining face face methods learning technologies improve learning outcomes mechanical engineering enhanced teaching environment includes upgraded teaching material new self assessment methods video clips providing detailed instructions practical session challenge improve learning method changing model simply presents practical sessions model actively involves students learning process results anonymous student satisfaction survey show improvements well received students consider new techniques useful better understanding subject preparing oral exam rates success demonstrate improvements direct significant impact performance well reducing dropout rate overall conclusion state new techniques effective tools improving learning outcomes degree mechanical engineering
given limitations current therapeutic options postmenopausal osteoporosis need alternatives minimal adverse effects study evaluated effects icaritin ict natural prenylflavonoid osteoclastogenesis vitro ovariectomized ovx rat model investigated underlying molecular mechanism action ict inhibited osteoclast formation two osteoclast precursor models raw mouse monocyte cell line human pbmc ict also inhibited sealing zone resorption pit formation dose dependent manner mechanistically ict inhibited rankl induced mapk pathways suppress gene expression nuclear factor activated cells nfat master transcription regulator osteoclast differentiation ict inhibiting traf src pik pathway suppressed nadph oxidase activation attenuate intracellular ros production downregulate calcineurin phosphatase activity result nfatc nuclear translocation activity suppressed crucially ict promoted proteasomal degradation traf critical adaptor protein transduces rankl rank signaling inhibitory effect ict osteoclastogenesis reversed proteasomal inhibitor ict administration inhibited ovx induced bone loss resorption suppressing osteoclast formation activity consistent cellular studies ict downregulated traf nfatc protein expression cdb low osteoclast precursors isolated ovx rats put together present novel findings ict downregulating traf coordinates inhibition mapk ros signaling pathways reduce expression activity nfatc results demonstrate potential ict treatment postmenopausal osteoporosis point traf promising target novel anti osteoporotic drugs american society bone mineral research
electron density topside ionosphere plasmasphere contributes essentially overall total electron content tec budget affecting global navigation satellite systems gnss signals plasmasphere cause half even gnss range error budget due ionospheric propagation errors paper presents comparative study different plasmasphere topside ionosphere data aiming establishing appropriate database plasmasphere modelling analyze electron density profiles along geomagnetic field lines derived imager magnetopause aurora global exploration image satellite radio plasma imager rpi records remote plasma sounding radio waves compare rpi profiles reconstructions topside ionosphere plasmasphere electron density derived gnss based tec measurements onboard challenging minisatellite payload champ satellite coincidences image profiles champ reconstructions detected region shell general champ reconstructed electron densities image profile densities median champ minus image residuals around additionally comparison made electron densities derived passive radio wave rpi measurements onboard image satellite available period image measurements considered combined data active passive rpi operations cover region within latitude range degrees longitudes shell ranging coincidence regions mainly check agreement available active passive rpi data comparison shows measurements well correlated median residual similar rms std values relative residuals around respectively summary results encourage application image rpi data plasmasphere plasmapause modeling cospar published elsevier ltd rights reserved
paper presents design project innovative concept single point incremental forming spif machine nowadays equipment currently available conducting spif result mostly adaptation conventional cnc machine tools results limited range applications terms materials geometries also limited market supply equipment dedicated incremental sheet forming isf costly considering low batches making unattractive industry factors impairing quicker spread spif large forming times poor geometrical accuracy parts following sections depict development new equipment designed overcome limitations machines currently used allowing development sounding basis studies particular features process equipment described possesses six degrees freedom tool sake improved flexibility terms achievable tool paths extra stiffness provided parallel kinematics scheme brief state art existing spif machines provided support project guidelines
levonorgestrel derivative progesterone effectively protects women unwanted pregnancy emergency contraceptive previous studies successful determining mechanism levonorgestrel acts present study analysed cilia beat action cilia morphology following levonorgestrel exposure vitro vivo using light electron microscopy significant decrease ciliary beat frequency cbf human fallopian tubes mucosal explants bathed mol levonorgestrel bathed medium alone tendency cbf decrease ampulla isthmus differences proliferative secretory phases rat oviducts levonorgestrel produced similar reduction cbf similar compared saline control group histological ultrastructural analysis demonstrated changes percentage ciliated cells classic structure cilia following levonorgestrel treatment either system thus levonorgestrel reduces cbf without damaging cilia morphology decreases cbf may indicate pathological role levonorgestrel transportation ovum zygote fallopian tube
background mobility changes concerning elderly patients cognitive decline given frail older individuals vulnerability injury critical identify contributors limited mobility objective examine whether structural brain abnormalities including reduced gray matter volume white matter hyperintensities would associated limited mobility among individuals cognitive impairment determine whether cognitive impairment would mediate relationship methods thirty four elderly individuals mild cognitive impairment mci alzheimer disease underwent neuropsychological evaluation mobility assessment structural brain neuroimaging linear regression conducted predictors including gray matter volume six regions interest roi white matter hyperintensity wmh burden mobility measures outcomes results lower gray matter volume caudate nucleus associated slower speed functional mobility task higher cerebellar volume also associated slower functional mobility white matter hyperintensity burden significantly associated mobility conclusion findings provide evidence associations subcortical gray matter volume speed functional mobility task among cognitively impaired individuals
leaf economics hydraulic traits strongly influence photosynthesis level coordination among traits differ sets species leaf functional trait coordination within species remains poorly understood furthermore elevated concentrations atmospheric commonly influence expression leaf photosynthetic economics hydraulic traits contrasting ways yet effect variable concentrations atmospheric patterns trait coordination within species remains largely untested examined relationships among key leaf photosynthetic net photosynthesis photosynthetic biochemistry economics water use leaf mass per unit area stomatal conductance hydraulic traits vein density genotypes eucalyptus camaldulensis grown ambient aco elevated eco examined level coordination among leaf traits aco assessed whether growth eco altered coordination found leaf traits related photosynthetic capacity economics water use hydraulics decoupled among genotypes grown aco yet strong relationships generally observed among suites traits within functional group significant responses growth eco observed leaf photosynthetic economics water use traits magnitude direction response varying among traits contrast leaf hydraulics traits unaffected variable growth despite growth eco substantially alter patterns leaf trait coordination observed aco results suggest suites leaf traits associated photosynthetic capacity economics water use hydraulics respectively form independent axes variation among genotypes single species regardless growth although growth eco substantially alter patterns trait coordination decoupling leaf functional traits among genotypes may allow genetically distinct populations produce novel combinations traits may adaptive response changes local environment
paper proposes new cmos based bandgap voltage reference generator bgr circuit using polysilicon resistors cmos technology reference generator uses three stage operational amplifier improved performance previously proposed bgr circuits proposed design simulated synopsys hspice simulator circuit produces output reference voltage room temperature degrees supply voltage analysis shows low temperature coefficient ppm degrees obtained output reference voltage temperature range degrees degrees using poly silicon resistor area reduced without losing much control current consumption
due fact existing database systems increasingly difficult use improving quality usability database systems gained tremendous momentum last years particular feature explaining expected tuples missing result query received attention paper study problem explaining missing answers top queries context sql selection projection join aggregation approach problem use query refinement method given inputs original top sql query set missing tuples algorithms return user refined query includes missing tuples original query results case studies experimental results show algorithms able return high quality explanations efficiently
many decades known tumor dna shed blood consequence technological limitations researchers unable comprehensively characterize circulating dna advent ultrasensitive highly specific molecular assays provided comprehensive profile molecular characteristics dynamics circulating dna healthy subjects cancer patients new tools hand significant interest provoked innovative type tumor biopsy termed liquid biopsy liquid biopsies obtained minimal invasive blood draws cancer patients circulating cancer cells exosomes variety molecules contained within liquid biopsy including cell free circulating tumor dna ctdna serve promising tools track cancer evolution attractive features ctdna ctdna isolation straightforward ctdna levels increase decrease response degree tumor burden ctdna contains dna mutations found primary metastatic lesions consequently analysis circulating dna cancer specific mutations might prove valuable tool cancer detection moreover capacity screen ctdna serial liquid biopsies offers possibility monitor tumor progression responses therapy influence treatment decisions ultimately may improve patient survival focus mutation detection ctdna provide overview characteristics ctdna detection methods ctdna feasibility ctdna monitor tumor dynamics current challenges associate ctdna also discussed
wine estate need demarcate homogeneous within vineyard zones terroirs manage grape production depends vine biological condition studies performing digital zoning terroirs relied recent spatial data scant attention paid ancient geoinformation likely retrace past biological condition vines especially occurrence vine mortality vine mortality characterized recurrent specific patterns patterns related terroir units past landuse study aimed performing historical spatial tracing vine mortality patterns using long time series aerial survey images combination recent data soil apparent electrical conductivity measurements high resolution pleiades satellite images detailed field survey within estate southern rhone valley landuse planting history retraced map missing vines frequency constructed whole time series including pleiades panchromatic band within field terroir units obtained support vector machine classifier computed spectral bands ndvi pleiades images data morphometric data repeated spatial patterns missing vines highlighted throughout several plantings uprootings vine replacements appeared match within field terroir units explained specific soil characteristics vine soil management choices past landuse missing vines frequency spatially correlated topsoil caco content negatively correlated topsoil iron clay total organic contents ndvi retrospective spatio temporal assessment terroir therefore brings renewed focus key parameters maintaining sustainable grape production author published elsevier open access article license
psana photon science analysis software package used analyze data produced linac coherent light source ray free electron laser slac national accelerator laboratory project began written primarily python provides user interfaces python users use python interface code run real time data taken well offline executing many nodes cores using mpi parallelization publicly available installable rhel operating systems
years growing body evidence indicates certain cognitive skills critical determinant leader performance present effort show application skills typically founded case based knowledge subsequently identify nine key skills people leadership positions employ working case based knowledge address leadership problems problem definition cause goal analysis constraint analysis planning forecasting creative thinking idea evaluation wisdom sensemaking visioning individual situational contingencies shaping effective application thinking skills discussed addition implications findings bearing leader thinking skills leader assessment leader development considered elsevier inc rights reserved
cross sectional study conducted group subjects older malaysia aimed determine risk factors associated cognitive impairment older adults focusing trace elements dna damage cognitive decline determined montreal cognitive assessment moca oxidative stress markers malondialdehyde mda superoxide dismutase sod determined dna damage assayed using alkaline comet assay toenail samples taken analyzed using icp determine trace element levels total subjects cognitive impairment subjects cognitive impairment significantly higher levels mda dna damage compared group normal cognitive function mda nmol nmol dna damage tail density tail moment parameters however level sod among subjects cognitive impairment min protein lower level among normal cognitive functions min protein multiple logistic regression revealed predictors cognitive impairment among subjects dna damage adjusted odd ratio confidence interval level trace elements toenails namely lead copper high levels lead copper lead increase oxidative stress levels associated dna damage eventually could associated cognitive decline
performance three geosynthetic clay liners gcls arsenic bearing gold mine tailings examined based series laboratory column experiments conducted two year period gcls examined either untreated polymer enhanced sodium bentonite different carrier geotextiles woven geotextile scrim reinforced nonwoven geotextile woven geotextile laminated polypropylene film months hydraulic conductivity gcl untreated sodium bentonite increased almost order magnitude swell index decreasing exchangeable sodium percentage esp decreasing samples gcl exhumed months moisture uptake cation exchange subjected extreme wet dry cycles experienced increase gcl polymer enhanced bentonite maintained less months virgin experienced less cation exchange esp decreased gcl untreated bentonite gcl extreme wet dry cycles gave cover soil gcl gcl polymer enhanced bentonite carrier geotextile laminated polypropylene geofilm demonstrated best performance even exposure extreme wet dry cycling cases gcl prevented arsenic migration overlying cover soil two year period examined elsevier ltd rights reserved
recent years complement analysis body fluids biopsies going far beyond significantly enhanced understanding disease process expanded complement analysis allows precise differential diagnosis critical monitoring complement targeted therapy changes result growing understanding involvement complement diverse set disorders appreciate importance proper complement analysis important understand role plays disease historically absence complement manifested severe infection noted since complement connected variety inflammatory disorders autoimmune diseases hereditary angioedema role complement rejection renal grafts known longer significant impact complement certain nephropathies led reclassification rare kidney diseases increased role complement analysis diagnosis even unexpected complement also implicated neural ophtalmological dermatological disorders level involvement varied impactful health issues proper complement testing clearly important however analysis complement system varies widely among laboratories except proteins neither well characterized standard preparations calibrated assays available especially true inter laboratory variation tests assess classical alternative lectin pathway function addition need standardization measurement complement activation products critical determining whether clinically relevant complement activation occurred vivo finally autoantibodies complement proteins anti convertases nephritic factor regulatory proteins anti clinhibitor anti factor important defining autoimmune processes diseases based complement dysregulation improve quality complement laboratory analysis standardization commmittee international complement society ics international union immunological societies iuis formed provide guidelines modern complement analysis standards development international testing programs elsevier gmbh rights reserved
objective purpose study determine effect two extraoral computer aided design cad computer aided manufacturing cam systems comparison conventional techniques marginal fit monolithic cad cam lithium disilicate ceramic crowns study design vitro interventional study place duration study study carried department prosthodontics school dentistry prince sattam bin abdul aziz university saudi arabia december april methodology marginal gap lithium disilicate crowns evaluated scanning electron microscopy total pressable lithium disilicate ips max press ivoclar vivadent ceramic crowns fabricated using conventional lost wax technique control group experimental ceramic crowns produced based scan stone model milled using two extraoral cad cam systems cerec group fabricated using cerec cad cam system trios group fabricated using trios cad milled using wieland zenotec cam one way analysis variance anova scheffe post hoc test used statistical comparison groups alpha results mean standard deviation marginal gap group follows control group cerec group trios group one way anova scheffe post hoc test showed statistically significant difference marginal gap groups conclusion concluded current study ceramic crowns fabricated using cad cam system show marginal accuracy acceptable clinical environments trios cad group displayed smallest marginal gap
background salivary cortisol measurement non invasive method suitable use neonatal research mother infant separation birth represents stress skin skin contact ssc numerous benefits aim study measure salivary cortisol mothers newborns ssc order assess effect ssc mothers infants stress estimate efficacy collecting small saliva samples newborns methods salivary cortisol measured mother infant pairs first fifth ssc small saliva samples using high sensitivity quantitative elisa kit nmol low cortisol levels detection samples collected eye sponge minutes results cortisol level mothers decreased ssc highest levels measured lowest ssc differences values significant first fifth ssc first ssc cortisol level decrease detected increase newborns fifth ssc decrease detected increase newborns without confirmed significance difference saliva sampling efficacy using eye sponge conclusions cortisol level decrease mothers proves stress reduction ssc variable cortisol levels infants indicate stress reduction imply need research used sampling method appeared one optimal considering sample volume sampling time efficacy
study examined incidence ptsd psychiatric morbidity among women experienced stillbirth investigated relationship locus control trauma characteristics stillbirth posttraumatic cognitions ptsd morbid psychiatric symptoms following stillbirth fifty women recorded information stillbirth experiences completed posttraumatic stress diagnostic scale general health questionnaire edinburgh post natal depression scale rotter locus control scale posttraumatic cognitions inventory met diagnostic criteria probable full ptsd partial ptsd respectively sixty two percent scored cutoff general health questionnaire postnatal depression respectively women experienced stillbirth reported significantly psychiatric morbid post natal depressive symptoms comparison group groups similar locus control women experienced stillbirth reported negative cognitions self adjusting postnatal depression trauma characteristics significantly correlated posttraumatic cognitions turn significantly correlated ptsd psychiatric morbidity locus control significantly correlated psychological outcomes mediational analyses showed negative cognitions self mediated relationship trauma characteristics psychiatric morbidity women reported high incidence probable ptsd morbid psychiatric symptoms following stillbirth stillbirth trauma characteristics influenced negatively perceived specifically influenced general psychological problems rather ptsd symptoms
high performance applications filter must added auxiliary resonant snubber inverter arsi reduce output current ripple however resonance occurs due additional filter makes traditional closed loop control suitable used directly therefore paper presents double loop digital control based active damping method capacitor current feedback stabilize system studies active damping methods focused grid consideration zero resistance however load resistance neglected drive system therefore load resistance digital control delays considered paper moreover improved loading method proposed improve duty ratio range order verify effectiveness controller prototype developed simulation experimental results demonstrate soft switching realized entire load range maximum duty ratio improved using proposed loading method resonance eliminated using proposed control method
people syndrome high risk developing alzheimer disease relatively young age increased risk observed people intellectual disabilities reasons reason unlikely due non specific effects neurodevelopmental disorder instead direct consequence genetics trisomy given location amyloid precursor protein app gene chromosome amyloid cascade hypothesis dominant theory accounting risk genetic environmental factors modifying age onset course disease several potential therapies targeting amyloid pathway aiming modify course currently investigated may also useful treating however given neuropathology associated starts many years dementia manifests preventative treatment must start well onset symptoms enable trials interventions plasma csf brain retinal biomarkers studied proxy early diagnostic outcome measures systematic review consider prospects development potential preventative treatments population evaluation
current glucose monitoring techniques neonates rely heavily blood glucose monitors require intermittent blood collection skin penetrating pricks heel fingers procedure painful often clinically conducive presents need noninvasive method monitoring glucose neonates motivation study develop vitro method measuring passive diffusion glucose premature neonatal skin using porcine skin model model allow initially test new devices noninvasive glucose monitoring without vivo testing newborns vitro model demonstrated comparing uncompromised tape stripped skin line flow diffusion apparatus glucose concentrations mimic hypo normo hyper glycemic conditions neonate respectively transepidermal water loss tewl tape stripped skin approximately closely mimics tewl neonatal skin days post conceptional age tape stripped skin showed fold increase glucose diffusion compared uncompromised skin small concentrations collected glucose measured highly selective highly sensitive fluorescent glucose biosensor based glucose binding protein gbp demonstrated method glucose determination noninvasive painless makes especially desirable glucose testing neonates children study important step towards vitro model noninvasive real time glucose monitoring may easily transferred clinic glucose monitoring neonates
elevated morbidity mortality among jobseekers may partly explained adiposity previous studies unemployment body mass index bmi usually modelled associations linear produced inconsistent results however underweight obesity associated mortality weight loss weight gain associated stressful environment unemployment associated underweight obesity different subgroups associations may previously masked whilst affecting health divergent pathways investigated whether previously overlooked shaped association unemployment bmi could help explain jobseekers elevated morbidity mortality identify groups vulnerable underweight obesity unemployment used multinomial models simultaneously investigate associations unemployment bmi defined underweight overweight obesity working age adults understanding society ukhls moderating impacts unemployment duration demographic factors smoking explored current jobseekers likely underweight odds ratio confidence interval less likely overweight adjusted gender age education health smoking physical activity unemployed non smokers increased odds obesity underweight overweight associations apparent longer term jobseekers men jobseekers lower income households conclude unemployment associated underweight nonsmokers obesity results show unemployment adiposity relationship properly studied assuming unidirectionality effects suggest unemployment may affect health different groups via divergent adiposity mediated pathways authors published elsevier inc
nowadays demand energy saving green emission construction machinery especially hydraulic excavators highly increased result hybrid system promoted successfully applied automobile industry recently introduced hydraulic excavators aim paper propose new energy saving electro hydraulic circuit design generation potential energy hybrid excavators system power storage component electrical battery combined hybrid electro hydraulic actuator using electric motor electrical generator energy convention component addition control strategy used control hybrid excavator follow commands given driver optimize energy saving process generator battery also proposed paper effectiveness energy saving hybrid excavator clearly proven series experiments test rig including bucket cylinder analyses
background burning mouth syndrome bms chronic pain condition characterized persistent intraoral burning without related objective findings unknown etiology affects elderly females mostly satisfactory treatment bms aimed observe long term efficacy high velanfaxine doses combined systemic topical administered clonazepam particular subgroup bms patients respond current clinical management results eight years old females bms patients fulfilled inclusion criteria treated venlafaxine clonazepam mean months average duration symptoms baseline years overall mean daily pain intensity score vas pain tongue within oral mucosa accompanying oral facial dysesthesia five patients tasting abnormal patients positive history concomitant primary headache average score hamilton rating scale anxiety depression respectively previous ineffective treatments include anticonvulsants anti depressants patients responded decrease vas three months treatment mean vas remarkable adverse events conclusion bms deserves bottomless psychiatric evaluation management current available treatments fail treatment venlafaxine combined topical systemic clonazepam may effective refractory bms cases investigation large scale controlled study needed confirm results
background adults eating disorders show brain volume reductions frontal insular cingulate parietal cortices well differences subcortical regions associated reward processing however little known structural differences adolescents behavioural indications early stage aim first study investigate structural brain changes adolescents newly diagnosed compared healthy controls study whether cognitions correlate structural changes adolescents short duration methods fifteen adolescent females recently diagnosed age matched individuals scanned structural magnetic resonance imaging mri whole brain region interest analyses conducted using voxel based morphometry vbm cognitions measured self report questionnaires working memory performance measured neuropsychological computerized test results conclusions left superior temporal gyrus smaller volume adolescents correlated cognitions concerns eating weight shape working memory reaction time correlated positively insula volumes participants measurements restraint obsession negatively correlated temporal gyrus volumes positively correlated cerebellar striatal volumes thus adolescents recent diagnosis volumetric variations brain areas linked cognitions obsessions working memory findings emphasize importance early identification illness potential long term effects structure behaviour occur
background without neonatal initiation treatment patients glutaric aciduria type develop striatal injury first six years life resulting complex predominantly dystonic movement disorder onset motor symptoms may acute following encephalopathic crisis insidious without apparent crisis additionally called late onset described single patients diagnosed age years aim better characterizing understanding late onset analyzed clinical findings biochemical phenotype mri changes eight late onset patients compared eight control patients age years early diagnosis start treatment results late onset control patient either dystonia striatal lesions mri late onset patients high excretors four eight control patients two eight late onset patients diagnosed age years presenting dementia tremor epilepsy six diagnosed age years three asymptomatic mothers identified following positive screening result newborns three non specific general symptoms one additional mild neurological deficits frontotemporal hypoplasia white matter changes present eight subependymal lesions six late onset patients comparable age greater proportion late onset patients non specific clinical symptoms possibly subependymal nodules compared control patients particular comparison four clinically wise asymptomatic low excreting control patients conclusions clinical findings non specific frontotemporal hypoplasia subependymal nodules characteristic mri findings late onset trigger diagnostic investigation rare disease apart apparent non susceptibility striatal injury despite lack treatment patients late onset categorically different early treated control patients differences late onset patients early treated control patients likely reflect greater cumulative neurotoxicity individuals remaining undiagnosed untreated years even decades well higher long term risk high excretors intracerebral accumulation neurotoxic metabolites compared low excretors
registration concept one important popular aspects digital image processing using suitable computer programming techniques transformation two images new much informative image found paper three important basic medical image registration mir methods namely mir maximization mutual information mir using cross correlation fourier transform approach mir minimization similarity metric proposed accordingly two comprehensive applications performed using mir minimization similarity metric uses sum squared differences metric metric regular step gradient descent optimizer optimizer images two patients brain tumors registered different images patients different time growthiness tumor inside patient brain investigated thought paper provide comprehensive reference source researchers involved mir paper contains powerful explanation three methods medical image registration also provides two experimental results using mir minimization similarity metric
paper presents column level bit two stage analog digital converter adc based pseudo differential operational amplifier designed readout circuit ray sensor array low power hybrid adc employs incremental sigma delta adc cyclic adc achieving good trade accuracy conversion speed two stages share analog circuit reduce area power consumption test chip fabricated cmos technology hybrid adc column performed parallel power consumption simulation result reveals effective number bits enob bits
objective investigate effect exposure virtual reality environment preoperatively patient reported outcomes surgical operations background scarcity well developed quality improvement initiatives targeting patient satisfaction methods performed randomized controlled trial patients undergoing cranial spinal operations tertiary referral center patients underwent randomization immersive preoperative experience standard preoperative experience stratified type operation primary outcome measures evaluation vecu anesthesie generale evan score amsterdam preoperative anxiety information apais score markers patient experience surgical encounter results study period total patients mean age years females underwent randomization average evan score standard deviation standard preoperative experience difference confidence interval exposure immersive experience also led higher apais score difference addition led lower preoperative vas stress score difference higher preoperative vas preparedness difference vas satisfaction difference scores association identified vas stress score difference conclusions randomized controlled trial demonstrated patients exposed preoperative increased satisfaction surgical encounter harnessing power technology hospitals create immersive environment minimizes stress enhances perioperative experience
decades developed world highest rates unintended pregnancy united states finally shows signs improvement progress likely due large part increased use highly effective long acting reversible methods contraception methods placed require maintenance provide years contraception effective sterilization upon removal fertility returns baseline rates article addresses advances software improved use elimination barriers provide methods hardware novel delivery systems devices american society reproductive medicine
background objectivethe cytokine interleukin relatively new discovery however powerful stimulating tumor necrosis factor alpha tnf inflammatory conditions objective research explore fluctuations levels tnf saliva gingival crevicular fluid focus measurements taken clinical treatment chronic periodontitis material methodsfor purposes study total patients chronic periodontitis controls periodontally healthy recruited important clinical periodontal criteria established start research chronic periodontitis group given initial form periodontal care samples saliva gingival crevicular fluid collected exactly preceding following care levels tnf present saliva gingival crevicular fluid recorded via use elisa resultsat baseline levels tnf gingival crevicular fluid saliva significantly higher among patients chronic periodontitis group among patients control group hand baseline levels significantly lower gingival crevicular fluid saliva chronic periodontitis group control group significantly positive link found tnf levels two study groups treatment levels tnf saliva gingival crevicular fluid significantly lower chronic periodontitis group compared baseline readings however levels significantly higher conclusionultimately level present saliva gingival crevicular fluid might useful indicator condition expectations treatment care according results research proinflammatory impact could potentially linked intensity progression periodontitis
since reforming opening china experienced miraculous development investigate transformation upgrading china economy study focuses relationship economic growth electricity consumption secondary tertiary industry china paper captures dynamic interdependencies among related variables using theoretical framework based vector autoregressive var vector error correction vec model using macroeconomic electricity consumption data results show secondary industry unidirectional granger causality electricity consumption gross domestic product gdp however tertiary industry occurs gdp granger causes electricity consumption conclusions verified impulse response function variance decomposition study great significance reveal relationship industrial electricity consumption pattern economic development meanwhile suggests since china joined world trade organization wto trend economic transformation upgrading gradually appeared elsevier rights reserved
oral feeding intolerance ofi common complication patients acute pancreatitis variations blood glucose associated impaired gastrointestinal function date measures glucose variability investigated predict ofi patients investigate usefulness several glucose variability measures predicting occurrence ofi early course prospective cohort study six measures glucose variability calculated prior occurrence ofi multivariate binary logistic regression analyses conducted diagnostic performance accuracy glucose variability measures assessed prospectively enrolled patients developed ofi adjusting confounders admission blood glucose concentration mean blood glucose concentration significantly associated ofi odds ratio confidence interval odds ratio confidence interval respectively admission blood glucose mean blood glucose area curve positive likelihood ratios respectively blood glucose concentration refeeding standard deviation blood glucose concentration coefficient variation mean amplitude glycemic excursions significantly associated ofi hospital blood glucose concentrations associated subsequent development ofi patients particular admission blood glucose mean blood glucose could useful predictors ofi setting
background smoking contributes cardiovascular diseases cvd leading cause death large source healthcare costs western countries examined association income smoking cessation among smokers underwent coronary angiography national institute cardiac surgery interventional cardiology luxembourg methods data derived follow study conducted among patients patients smokers time coronary angiography four logistic regression models applied three models predictor income covariates sex age nationality marital status diagnosis body mass physical activity awareness tobacco cardiovascular risk factor model predictor interaction term composed income awareness tobacco risk factor variables covariates results among patients current smokers baseline current smokers follow quit smoking multivariate logistic models quitting smoking associated income even controlling socio demographic diagnostic behavioural risk factors full model odds quitting smoking among patients two highest income categories remained significant compared patients lowest income category odds ratio confidence interval respectively full model interaction term quitting smoking associated income patients knew tobacco risk factor odds smoking cessation times patients annual incomes sic sic respectively compared patients annual income sic conclusions study highlights influence income behaviours regarding cvd risk factors major cvd event patients highest income groups likely quit smoking although aware tobacco risk factor therefore intervention strategies targeting lower income groups implemented major health facilities
paper presents analyses phase shifter diversity receivers modulates vector constellation diagram system consists three stage programmable gain amplifier pga chain branches design covers full phase range degrees stage programmed amplify incoming signal centre frequency mhz radio frequency signal converted intermediate frequency mhz phase shifting done circuit intended automotive satellite radio receiver sand band thus demand automotive requirements fulfilled supply voltage compared phase shifters power consumption highly energy efficient system includes constant source biasing circuit requirements verified post layout corner monte carlo analysis using virtuoso wicked design takes silicon area cmos technology
objective study examined pocket premium burden mid life asian americans comparing six sub groups asians controlling geographic clustering county state levels method national health interview survey linked community level data analyzed asians ages including asian indians chinese filipinos japanese koreans vietnamese non hispanic whites included comparison group three level multilevel modeling state county individual conducted results koreans vietnamese found vulnerable sub groups considering lower private health insurance rates higher uninsured rates among private insurance asians specifically filipinos paid significantly less non hispanic whites moderate significant variations county state level variance pocket premiums found especially among mid life asians discussion study demonstrates importance examining within group heterogeneity geographic variations understanding premium burden among mid life asians
sufficient dietary fibre supply essential prevent digestive troubles growing rabbit recent recommendations implicated several classes fibre including low digested fibre lignocellulose digestible fibre hemicelluloses pectins moreover agro industrial products brans pulps rich digestible fibre often incorporated rabbit feeding although fibre fraction analysed current routine method therefore present review focuses respective role low digested digestible fibre fractions digestive health growing rabbit weaning gives levels fibre classes including pectins feed ingredients classically used rabbit feeding brief overview characteristics dietary fibre routine methods estimate fibre fractions animal feed ingredients presented elsevier science rights reserved
research seasonality mood long stymied lack data part due prohibitive cost traditional data collection tendency data highly localized recent work using social media data evinced utility psycholinguistic features tracking mood mental illness twitter data nonanonymous short form design almost exclusively subject analysis article present novel corpus within field study comments social network reddit suffer potential limitations find although notable changes mood entire population course year small cohort acutely sensitive changes relative day length relative photoperiod findings corroborate phase shift hypothesis prevailing theory seasonality mood also demonstrate viability reddit comments corpus studies mood broadly mental health
dna origami enables precise fabrication nanoscale geometries demonstrate approach engineer complex reversible motion nanoscale dna origami machine elements first design fabricate characterize mechanical behavior flexible dna origami rotational linear joints integrate stiff double stranded dna components flexible single stranded dna components constrain motion along single degree freedom demonstrate ability tune flexibility range motion multiple joints simple motion integrated higher order mechanisms one mechanism crank slider couples rotational linear motion bennett linkage moves compacted bundle expanded frame configuration constrained motion path finally demonstrate distributed actuation linkage using dna input strands achieve reversible conformational changes entire structure similar minute timescales results demonstrate programmable motion dna origami mechanisms constructed following macroscopic machine design approach
introduction low sexual desire men condition received little attention nevertheless occurs high frequency clinicians need clear guidelines address problem aim develop standardized operational procedures implemented men presenting low sexual desire interest lsd methods review relevant evidence based literature published guidelines integrated expert opinion main outcome operational procedures lsd recommended clinical practice various degrees support published evidence results new classification scheme proposed lsd proposed umbrella term hypoactive sexual desire disorder hsdd subtype following standard operational procedures described detection lsd screening lsd screening lsd patients sexual dysfunctions diagnosis assessment etiology diagnostic criteria lsd assessment depression status assessment relationship status assessment endocrinologic status diagnostic criteria hsdd men iii treatment treatment lsd secondary low testosterone treatment lsd secondary elevated prolactin treatment lsd secondary endocrinologic disorders treatment lsd secondary depressive illness anxiety disorders treatment lsd secondary relationship conflict treatment hsdd diagnostic treatment algorithm presented conclusions lsd common condition identified patients recommended condition actively investigated clinician diagnosis lsd men confirmed thorough search possible causes needs include biological psychological causes treatment etiologically oriented rubio aurioles bivalacqua standard operational procedures low sexual desire men sex med
objective proposed inflammatory cytokine system regulated vagus nerve vagal activation inhibits release inflammatory cytokines therefore inflammation thus loss vagal activation reduced high frequency heart rate variability hrv result greater inflammation evidence date relationship relied animal models resting states humans present study used psychosocial stressor test whether stress induced decreases hrv predict increases circulating inflammatory markers methods thirty healthy young women completed speech stressor hrv assessed stressor circulating plasma interleukin tumor necrosis factor reactive protein assessed hour stressor results consistent neural reflex immunity greater reductions hrv stressor associated greater increases tumor necrosis factor alpha beta interleukin beta reactive protein beta hour stressor conclusions findings expand current literature showing changes hrv predict precede changes circulating inflammatory cytokines humans may implications treatment inflammatory diseases
hybrid energy system used robotic tractors precision weed pest control agriculture evaluated exhaiist emissions compared use internal combustion engine single power source agricultural implements require power hydraulic pumps fans initially provided power take system pto wasting lot energy objectives work design assess hybrid energy system including removal alternators tractor modification agricultural implements replace pto power electric power using small pumps small fans changes improved energy use reduced atmospheric pollution emission internal combustion engine hybrid energy system used original combustion engine tractor combination new electrical energy system consisted hydrogen fuel cell analysis exhaust gases using internal combustion engine single power source using hybrid energy system carried compare results obtained results showed reduction emissions almost best case iagre published elsevier ltd rights reserved
authors propose generalised multi layer architecture phase shifter network psn hybrid analogue digital beamforming provides flexible trade offs performance implementation complexity changing layer number authors adjust complexity psn achievable performance two stage algorithm adopted analogue digital matrices designed separately analogue adaptive second order channel statistics simple iterative algorithm proposed maximise upper bound average rate effective channel analogue digital adaptive effective channel multiuser interference cancellation ideal phase shifters discrete phase shifters limited phase amplitude resolutions considered algorithm design theoretical analysis simulation used demonstrate good performance flexibility proposed technique antenna system use radio frequency chains perform closely full digital fully connected psn achieve performance simple psn also robust limited phase shifter resolution enables select proper performance implementation complexity according requirement capability real systems
electrical conductivity percolation threshold field grading polymer composites intended high voltage applications examined representative elementary volume simulation methods based percolation threshold modeling ptm electrical network modeling enm comparisons made experimental conductivity data sic epdm composites spherical angular particles using different filler fractions electrical field strengths known conductivity filler particles powder simulations could predict percolation threshold composite conductivity functions electrical field wide range sic filler fractions effects morphology dispersion filler shape examined simulations able explain experimental difficulty reaching sufficient reproducibility designing composites filler fractions close percolation threshold ptm composites containing hard core soft shell spheres revealed relationship filler fraction relative soft shell thickness
paper investigate higher order rogue wave solutions kundu eckhaus equation contains quintic nonlinearity raman effect nonlinear optics means gauge transformation kundu eckhaus equation converted extended nonlinear schrodinger equation derive lax pair generalized darboux transformation nth order rogue wave solution extended nonlinear schrodinger equation using gauge transformation two equations concise unified formula nth order rogue wave solution several free parameters kundu eckhaus equation obtained particular based symbolic computation explicit rogue wave solutions kundu eckhaus equation first third order presented figures illustrate dynamic structures rogue waves first fourth order moreover numerical calculations plots show quintic raman effect nonlinear terms affect spatial distributions humps higher order rogue waves although amplitudes time appearance humps unchanged
background patient suicide prevention high priority many countries practice remains poorly understood patients suicidal crisis receive psychiatric care provide valuable insight understanding improving patient safety aim paper therefore summarize qualitative literature regarding suicidal patients patient care experiences following question guided review describe suicidal patients experiences regarding safety psychiatric patient care methods systematic searches conducted medline academic search premier cinahl socindex psycinfo databases identifying qualitative studies suicidal patients psychiatric patient care experiences studies systematically reviewed using preferred reporting items systematic reviews meta analyses prisma guidelines synthesized via thematic analysis subjected quality appraisals results patients described safety feeling safe three components connection protection control vital experiences safety fulfilling needs essential patients recovering suicidal crises feeling safe encounters health care professionals feeling safe suicidal impulses unmet needs connection protection control left patients feeling unsafe increased suicidal behaviour conclusion review addresses importance adopting wider perspective patient safety considering safety solely technical physical terms safety suicidal patient highly dependent patients perceptions psychological safety fulfilment needs three patient identified factors mentioned connection protection control considered integral part patient safety practices form basis future efforts understand safety suicidal patients psychiatric patient care
background possessing correct therapeutic information oral contraceptives important prerequisite provision sound advice women using products objectives study examines egyptian pharmacists knowledge pharmacotherapeutic aspects oral contraceptives well interest developing skills providing counseling oral contraceptive pills setting community pharmacies throughout alexandria egypt methods cross sectional survey self administered random sample community pharmacists alexandria egypt five multiple choice questions likely arise counseling women oral contraceptives constructed questions covered compatibility breastfeeding precautions health risks managing missed pills oral contraceptives using ordered logistic regression model estimated predict pharmacists interest developing skills providing counseling oral contraceptives main outcome measure pharmacists aggregate scores knowledge questions pharmacists interest developing skills providing counseling oral contraceptive pills results approached pharmacists participated twenty one pharmacists know correct answer question answered one two correctly answered three four correctly pharmacist answered five questions correctly pharmacists interest developing skills providing counseling oral contraceptives percentage values answers interested slightly interested somewhat interested interested extremely interested pharmacists interest developing skills providing counseling oral contraceptives significantly associated number women requested advice pharmacists oral contraceptives terms learning method preference percentage values answers attending workshop online course publications distributed pharmacy methods one method ten percent interested developing skills oral contraceptives conclusion study identifies considerable gaps among community pharmacists knowledge oral contraceptives also shows variation willingness choice learning strategies among pharmacists develop skills providing counseling oral contraceptives
study proposes method estimating phytoplankton cell counts associated algal bloom using satellite images coincident situ meteorological parameters satellite images landsat thematic mapper enhanced thematic mapper plus etm operational land imager old charge couple device ccd sensors integrated meteorological observations provide estimate phytoplankton cell counts images atmospherically corrected using second simulation satellite signal solar spectrum atmospheric correction method possible error blue green red near infrared nir wavelengths respectively results showed developed artificial neural network ann model yields correlation coefficient situ validation data sum squared error sse cell mean relative error mre cells bias integration meteorological parameters remote sensing observations provided promising estimation algal scum compared previous studies applicability ann model tested hong kong well lake kasumigaura japan lake okeechobee florida usa algal blooms also reported year red tide occurrence map developed revealed eastern southern waters hong kong vulnerable red tides years red tide incidents associated dinoflagellates group remainder associated diatom group several minor groups developed technology applied similar environments efficient cost saving manner elsevier rights reserved
past decade mechanical characterization data nanoparticle reinforced polymer matrix composites shown significant improvements compressive strength interlaminar shear strength comparison baseline properties synergistic reinforcing influence nanoparticle reinforcement obvious simple rule mixtures approach fails quantify dramatic increase mechanical properties consequently immediate need investigate understand mechanisms nanoscale responsible unprecedented strength enhancements multi scale multi physics simulation approach considered computationally viable since relying single time length scale may require huge amounts computational resources potentially lead inaccurate results proof concept case study involving crack initiation graphene nanoplatelet presented together methodology computing atomistic integral based hardy estimates continuum fields methodology used gain better understanding influence nanoscale phenomena continuum scale mechanical properties polymer nanocomposite envisioned current research contribute towards understanding advanced nanostructured composite materials within context integrated computational materials engineering
despite continually increasing evidence effectiveness psychodynamic psychotherapy general empirical status long term psychodynamic psychotherapy ltpp remains controversial convincing outcome studies ltpp lacking long time article gives overview available systematic reviews addressing evidence ltpp findings suggest ltpp yield large stable effects across variety diagnoses particularly complex mental disorders even tend increase termination treatment comparison shorter less intensive methods psychotherapy ltpp proven significantly superior respect outcome domains first economic analyses suggest ltpp may cost effective long run comparison randomized controlled observational studies revealed significant differences outcome however evidence ltpp frequently challenged proponents therapeutic approaches scientific orientations criticisms repeatedly answered none concerns raised critics identified issue would affected overall conclusions available reviews nevertheless studies urgently required broaden evidence base ltpp order allow refined analyses addressing effects specific forms ltpp specific disorders comparison specific forms alternative therapies
several studies lab others demonstrated age related declines mnemonic discrimination recognition memory paradigm using repeated items similar lures novel foils particular older adults exhibit shift lure discriminability identifying similar lures old items greater rate young adults shift likely reflects deficits pattern separation processing result underlying changes dentate gyrus hippocampus explored whether alterations task design could rescue age related impairment whether ubiquitous one might expect neurobiological mechanisms truly disturbed typical aging despite overt instructions study item details encoding replicated age related deficit mnemonic discrimination established reliable effects short lists stimuli repeated testing altering task design study test continuous recognition paradigm replicated age related shift lure discrimination well modifying task old new response rather old similar new showed effect analysis showed lure items akin target items older adults finally varied test instructions order promote gist veridical responses old new task even overt veridical test instructions ameliorate older adults lure discrimination problems together findings demonstrate robust nature age related deficit support hypothesis typical aging results neurobiological changes underlie impairment
introduction hepatitis virus hcv infects nearly million people worldwide leading cause progressive liver damage cirrhosis hepatocellular carcinoma curative therapies historically relied interferon based treatments limited significant toxicity poor response rates particularly among patients prior treatment failure advanced hepatic fibrosis recent advent direct acting antiviral daa agents target key steps hcv viral life cycle transformed landscape hcv treatment offering highly effective well tolerated interferon free treatments however current therapies genotype specific variable efficacy amongst less prevalent hcv variants areas covered review covers preclinical clinical development sofosbuvir velpatasvir sof vel interferon free daily pangenotypic treatment treatment chronic hepatitis virus hcv infection relevant literature september included expert opinion sof vel offers promise single tablet interferon ribavirin free treatment extremely high efficacy persons chronic hcv infection regardless genotype subtype treatment history fibrosis status expected play major role global scale therapeutic armamentarium ubiquitous threat human health
main aim cross sectional study analyse degree coping may act mediator disability psychosocial loss people relapsing remitting multiple sclerosis participants completed measures psychosocial loss ways coping disability status evaluated attending neurologists coping partially mediated relationship disability psychosocial loss disability leads experience psychosocial loss sole factor determining formation psychosocial loss coping also associated losses multiple sclerosis
virtual reality surgical training presurgical planning require creation virtual models patient anatomy medical scans mri real time head tracking applications allows users navigate virtual anatomy position orientation process interactively rendering highly detailed volumetric data anatomical models dynamically changing observer perspective extremely demanding computational resources propose parallel computing solution problem involving distributed volume graphics rendering system composed multiple nodes concurrently working different frames output stream later integrated form final animation scenario important consider frame losses generated order arrivals output sequence images paper presents study frame losses distributed graphics rendering system consisting multiple gpu based heterogeneous nodes running best effort rendering scheme applying alternate frame rendering technique describe mathematical model frame losses well performance evaluation comparing model predictions experimental results elsevier ltd rights reserved
pseudomonas aeruginosa induced keratitis rapidly progressive ocular infectious disease often leads inflammatory epithelial edema stromal infiltration tissue destruction corneal ulceration vision loss study investigate role tripartite motif trim regulating inflammatory process induced keratitis expression trim increased mouse corneas vitro cultured macrophages infection knockdown expression trim significantly inhibited activation kappa signaling decreased production proinflammatory cytokines vivo vitro infected furthermore investigated potential mechanism found infection trim could promote linked poly ubiquitination transforming growth factor beta activated kinase tak leading activation tak enhanced inflammatory responses taken together demonstrated trim proinflammatory effect induced keratitis suggest trim potential therapeutic target keratitis
visual tracking popular research area computer vision difficult actualize challenges changes scale illumination rotation fast motion occlusion consequently focus research area make tracking algorithms adapt changes implement stable accurate visual tracking paper proposes visual tracking algorithm integrates scale invariance surf feature deep learning enhance tracking robustness size object tracked changes significantly particle filter used motion estimation confidence particle computed via deep neural network result particle filter verified corrected mean shift computational efficiency insensitivity external interference qualitative quantitative evaluations challenging benchmark sequences demonstrate proposed tracking algorithm performs favorably several state art methods throughout challenging factors visual tracking especially scale variation
healthcare organizations becoming increasingly complex need use simulation techniques tool provide consistently safe care mastery learning techniques minimize variation learner outcome thus improving consistency cost effectiveness care today organizations teams decision makers exist within varying states transformation transformational times afford opportunities use mastery learning concepts organizational level affect necessary change evolving technologies including simulation provided mechanisms enhance system performance reducing reliance custom built problem solving solutions individual system needs simulation emerged increasingly necessary organizational tool improving value driven consistent processes care computer based non computer based algorithms healthcares imulations offer distinct advantages improving system performance traditional methods quality improvement simulation process engineering tool integrated mastery learning techniques provides powerful platforms improving value based care
osteoporosis serious health problem worldwide microrna post transcriptional regulator gene expression either promoting mrna degradation interfering mrna translation specific target genes plays significant role pathogenesis osteoporosis first demonstrated mir mir negatively regulated osteogenic differentiation mesenchymal stem cells vitro found mir expression increased cbl mice glucocorticoid induced osteoporosis giop silencing mir signaling protected mice giop promoting bone formation inhibiting bone resorption last showed mir inhibited osteoblastic differentiation bone formation partly directly targeting bone morphogenetic protein bmp vitro giop model together findings identified role mechanism mir negatively regulating osteogenesis inhibition mir might potential new strategy treating osteoporosis bone defects published elsevier
background aligning multiple sequences arises many tasks bioinformatics however alignments produced current software packages highly dependent parameters setting relative importance opening gaps respect increase similarity choosing one parameter setting may provide undesirable bias steps analysis give simplistic interpretations work reformulate multiple sequence alignment multiobjective point view goal generate several sequence alignments represent trade maximizing substitution score minimizing number indels gaps sum pairs score function trade gives practitioner information similarity sequences could analyse choose plausible alignment methods introduce several heuristic approaches based local search procedures compute set sequence alignments representative trade two objectives substitution score indels several algorithm design options discussed analysed particular emphasis influence starting alignment neighborhood search definitions overall performance perturbation technique proposed improve local search provides wide range high quality alignments results conclusions proposed approach tested experimentally wide range instances performed several experiments sequences obtained benchmark database balibase evaluate quality results calculate hypervolume indicator set score vectors returned algorithms results obtained allow identify reasonably good choices parameters approach compared method terms correctly aligned pairs ratio columns correctly aligned ratio respect reference alignments experimental results show approaches obtain better results tcoffee clustal omega terms first ratio
arabinogalactan proteins agps belong class pro hyp rich glycoproteins complex types macromolecules found plants economically important plant species brassica rapa chimeric agps identified date significantly limited understanding functional roles agps plant study agps identified genome rapa including classical agps peptides three lys rich agps syntenic gene analysis rapa thaliana suggested whole genome triplication event dominated expansion agp gene family rapa resulted high retained proportion agp family rapa genome especially least fractionated subgenome phylogenetic motif analysis classified classical agps six clades three orphan genes peptides three clades five orphan genes classical agps faster rate molecular evolution peptides revealed estimation molecular evolution rates however significant differences observed classical agps lys rich agps control conditions response phytohormones treatment complete expression profiling experiment identified five anther specific agps quite number agps responding abscisic acid methyl jasmonate gibberellin study presented bioinformatics approach identify important types agps moreover association function protein structure well evolution expression agp genes investigated might provide fundamental information revealing roles agps rapa
background psoriasis one common dermatological conditions seen daily practice psoriasis known associated lipid profile abnormality increased fasting blood glucose levels increased waist circumference increase blood pressures collectively constitute called metabolic syndrome objectives studyto study serum lipid profile among psoriasis patients attending hospital study serum lipids relation severity psoriasis among patients materials methods study conducted navodaya medical college hospital research centre raichur patients newly diagnosed psoriasis received prior topical systemic treatment randomly selected study matched age sex matched controls complete lipid profile estimated measurement blood pressure collection data blood samples collected obtaining proper consent cases controls serum lipids measured enzymatic method results total consecutive cases psoriasis screened examined recruited detailed history taken thorough examination carried age sex matched controls also recruited blood tests carried assess levels total cholesterol ldl vldl hdl majority patients belonged years age group male female ratio patients mild psoriasis pasi psoriatic arthritis noted patients cases patients concomitant diabetes patients coexistent hypertension amongst various lipid parameters slight elevation found triglyceride values parameters like hdl vldl ldl total cholesterol show significant association correlation abnormality lipid parameters severity disease conclusion study show association psoriasis abnormality lipid profile plenty reports west approving association explained basis increased prevalence obesity abnormal bmi hypertension compared indian patients
capillary electrophoresis method hyphenated tandem mass spectrometry triple quadrupole qqq developed simultaneous determination six selected drugs used crohn disease treatment namely azathioprine thioguanine mercaptopurine mesalazine prednisone allopurinol ammonium acetate adjusted ammonium hydroxide including methanol addition used optimum background electrolyte bge optimum bge provided baseline electrophoretic separation drugs highly compatible connection electro spray ionization esi interface optimized working conditions favorable selective sensitive qqq detection separated compounds according mass charge ratios proposed method validated terms precision rsds repeatability migration times peak areas analyzed drugs less respectively linearity determination coefficient ranged interval limits quantitation sub levels accuracy mean recoveries analytes pharmaceutical matrix ranged interval esi qqq method fast simple selective precise accurate successfully applied highly reliable determination targeted drugs treatment inflammatory bowel disease ibd commercial pharmaceuticals tablet dosage forms
rail transit construction developing leaps bounds china traditional project management model shown discomfort informatization management modern concept project management provides new management model rail transit construction management becomes effective way change shortcomings traditional project management paper bases analysis characteristics requirements rail transit construction management presents informatization management system based integrated management thoughts analyses overall frame operation mechanism virtual reality decision support dynamic control proposes strengthen constructions three aspects including organizational institutional runtime environment informatization platform informatization technology ensure informatization management system rail transit construction running safely smoothly
goal ubiquitous computing create ambience one experiences quality life improved monitoring assisting people using ubiquitous technologies computation coherence continuous advancements involved technologies wireless communications mobile devices sensors imply fast evolution ubiquitous computing environments complexity environments reaching point traditional solutions simply longer work environments need computational techniques deal evolution uncertainty ubiquitous computing environments dynamically automatically artificial intelligence contribute towards satisfying future scenario many ways numerous approaches inspired work planning community already designed ubiquitous computing devote study investigate current progress planning ubiquitous computing analysing approaches rigorously search select relevant literature extract qualitative information using extracted qualities derive generic framework consists aspects important planning ubiquitous computing framework main purpose facilitate understanding aspects classify literature according analyse literature consolidated way identify future challenges planning ubiquitous computing
paper describes development decision support tool positioning sizing vortex flow controls existing sewer systems tool aims prioritise placement vortex flow controls primarily within subcatchments greatest flood consequence rating maximise use unused inpipe volumes critical rainfall events decision support tool intended use catchments opportunities implement suds rainwater harvesting defend flooding limited decision support tool envisaged identify potential strategies could enhance flood resistance sewer systems cost effective manner authors published elsevier ltd
aimsto estimate whether parental socio economic status ses associated adolescent drinking degree possible association may accounted various parental factors design settingcross sectional norwegian school survey response rate participantsstudents aged years years years girls measurementsparents education main ses indicator distinguished low middle high educational level outcomes comprised past year drinking intoxication also applied measures general parenting parents alcohol related permissiveness parental intoxication main analyses conducted using poisson regression findingsparents education statistically significant impact alcohol use among year olds year olds low educated parents elevated relative risk drinking confidence interval intoxication rrs became statistically insignificant including parental factors covariates regression models among adolescents consumed alcohol low parental education related frequent drinking intoxication episodes rrs became statistically insignificant accounted parental factors pattern replicated applied alternative indicator low parental ses conclusionsadolescent drinking norway appears related inversely parents social standing elevated risk low socio economic status vanishes general parenting alcohol related parental permissiveness parents drinking accounted
objectives smoking continues major health concern people history alcohol substance use problems current research aimed describe prevalence smoking residential addictions treatment services compare characteristics people quit smoking methods participants attending residential substance abuse treatment provided australian salvation army programs months length offer range low intensity smoking cessation supports measures smoking substance use clinical characteristics collected baseline three months post discharge treatment results baseline people smokers follow participants smokers baseline quit smoking participants quit smoking follow also reported higher rates abstinence alcohol substances follow people quit smoking conclusions potential smoking cessation better addressed part routine care substance abuse treatment settings future research evaluate provision systematic smoking cessation interventions within settings
smoking endemic drug abuse treatment populations smoking prevalence population appears unresponsive existing tobacco control strategies clinical policy guidelines encourage programs address smoking among clients research identified key barriers report explores practice staff clients smoking together drug treatment programs practice associated tobacco related measures clients surveyed program directors interviewed national sample drug abuse treatment programs affiliated nida clinical trials network clients asked whether observed staff clients smoking together program using program unit analysis measure tested association client level program level tobacco related outcomes higher rates staff client smoking together associated higher staff smoking prevalence lower rates client thoughts quitting next days negative client attitudes toward quitting smoking clients receiving fewer tobacco related services findings illuminate actionable low cost policy intervention address smoking drug abuse treatment prohibit practice staff smoking together clients interest health clients serve counselors program directors state regulatory agencies federal funding agencies act end practice elsevier inc rights reserved
social identity theory suggests people use social categories race gender basis interpersonal judgments demonstrate biases favoring ingroups discrimination groups includes hiring personnel decisions research examines whether context information participants use person religion show typical intergroup biases often seen racial groups one hundred seventy five black christian participants viewed fictional job applicants different religions christian muslim atheist races black white thirty two percent participants explicitly reported using applicant religion seldom reported using race source evaluation showed consistent preference christian ingroup muslim atheist outgroup applicants contrast acknowledge using religion showed racial ingroup bias none religion research implications workplace discrimination hiring practices racial religious group relations western social science association published elsevier inc rights reserved
paper investigates whether female independent directors likely impose high dividend payouts find evidence firms larger fraction female directors board greater dividend payouts finding robust alternative econometric specifications alternative measures dividend payouts female board representation positive effect board gender composition dividends remains employ propensity score matching instrumental variable approach difference differences approach address potential endogeneity concerns furthermore find board gender composition significantly increases dividend payout firms weak governance suggesting female directors use dividend payouts governance device authors published elsevier open access article license http creativecommons org licenses
accurate speedy estimations ppm range uranium thorium geological rock samples useful towards ongoing uranium investigations identification favorable radioactive zones exploration field areas study existing nai detector setup prevailing background time constraints enhanced geometrical setup worked improve minimum detection limits primordial radioelements geometrical setup integrated newly introduced digital signal processing based mca system routine spectrometric analysis low concentration rock samples stability performance long counting hours digital signal processing mca system predecessor nim bin based mca system monitored using concept statistical process control monitored results time span months quantified terms spectrometer parameters compton striping constants channel sensitivities used evaluating primordial radio element concentrations geological samples results indicate stable dmca performance tendency higher relative variance mean particularly compton stripping constants elsevier ltd rights reserved
several stepped spillways built recent decades mostly integrated downstream faces roller compacted concrete dams among changing bottom slopes comprehensive information effect slope change flow features lacking paper reports systematic study air entrainment flow bulking skimming flow along stepped spillways vicinity abrupt slope changes physical modelling conducted using large facility abrupt pseudo bottom slope changes degrees degrees degrees degrees air water flow measurements conducted several flow cross sections upstream downstream slope change results indicate significant influence slope change air pattern flow bulking four main flow sub regions identified describe typical air water flow patterns normalized length influence reach induced slope change found depend mainly critical flow depth regardless slope change step height
aim evaluate risks medical conditions evaluate gastric sleeve narrowing assess hydrostatic balloon dilatation treat dysphagia vertical sleeve gastrectomy vsg methods vsg performed frequently worldwide treatment medically complicated obesity dysphagia common post operatively hypothesize post operative dysphagia related underlying medical conditions narrowing gastric sleeve retrospective single institution study consecutive patients underwent sleeve gastrectomy patients previous bariatric procedures excluded narrowing gastric sleeve includes inability pass gastroscope due stenosis sharp angulation spiral hindering passage results consecutive patients included prevalence dysphagia patients narrowing sleeve sharp angulation spiral stenosis patients underwent balloon dilatation gastric sleeve dysphagia resolved patients patients noted resolution dysphagia two additional dilatations multivariate model medical conditions associated post operative dysphagia include diabetes mellitus symptoms esophageal reflux low whole blood thiamine level hypothyroidism use non steroidal anti inflammatory drugs use opioids conclusion narrowing gastric sleeve gastric sleeve stenosis common vsg endoscopic balloon dilatations gastric sleeve resolves dysphagia patients
paper describes new design reforming system converting hydrocarbon fuels pure hydrogen system based autothermal reforming atr reactor operating elevated pressures followed membrane based hydrogen separation high pressure membrane discharge stream combusted expanded turbine generating additional power process simulation modeling illustrates effect pressure operating parameters system performance demonstrates system reforming efficiency approaching coupled pem fuel cell electrical generator fuel electricity efficiency anticipated benefits system include compact size simplicity control fast start elsevier rights reserved
traveler medical kit essential tool novice expert traveler designed treat travel related illness injury ensure preexisting medical conditions managed appropriately travelers increased risk common gastrointestinal issues travel respiratory illnesses make approximately ailments present returned international travelers approximately travelers experience travel related skin condition first aid treatment minor injuries essential travel medical kits complexity ranges small simple case urban traveler larger extensive case wilderness travel
osteoporosis frequent bone disease without typical early symptoms serious complications low energy bone fractures patients risk factors screened proper diagnosis early possible unfortunately registered medical data often highly imbalanced machine based data processing difficult even impossible considering goal search best method coping problem imbalancing relation analysed data regarding osteoporotic patients therefore checked several paradigms classifiers synergy preprocessing techniques address inner skewed class distribution data source dataset instances related patients without fractures negative cases patients positive cases reported least one fracture alleviate class imbalance examined data level methods fact modify input dataset also ensemble ones strengthen results base algorithms first group sampling methods used random undersampling edited nearest neighbours synthetic minority sampling techniques second one range methods based various subsets training data analysed also various combinations mentioned investigated additionally propose way find balancing level without excessive distortion input raw data give appropriate classification efficiency aim experiment identify undersampling oversampling approach reference simple ensemble based classifiers allows achieve best results outcomes comparative studies concerning imbalancing problem regard dataset showed highest efficiency achieved using synthetic minority sampling technique randomforest classifier far optimal balancing level concerned empirically determined oversampling thesynthetic minority sampling method combined edited nearest neighbours undersampling allowed gain required precision classification elsevier inc rights reserved
twenty five dromedary camel foetuses ranging crown vertebral rump length collected slaughtering evacuation uterus specimens processed stained haematoxylin eosin periodic acid schiff reaction morphological histological examinations mesonephros detected camel foetus reached maximum maturity started degenerate completely generated camel foetus
paper reported activities laboratory manufacturing technology ntua manufacturing engineering focusing onto recent trends developments advanced manufacturing advanced materials mainly emphasizing long standing greek ukrainian russian hungarian scientific cooperation also international involvement worldwide principal research important engineering topics nowadays industrial research academic point view ultraprecision engineering nanotechnology net shape manufacturing high temperature ceramic superconductors elsevier rights reserved
operating voltages low voltage control circuits power plants substations decreased installation digital control equipment increases susceptibility control equipment abnormal surges arise mainly lightning protect control equipment lightning necessary predict lightning surges invading power plants substations design effective lightning protection methodologies compared conventional simulation techniques based circuit theory full wave numerical approaches advantageous handling three dimensional structures transmission line towers grounding structures nonhorizontal wires incoming power lines power plants substations lightning induced effects study apply finite difference time domain fdtd method lightning surge analysis air insulated substation first propose techniques simulating nonlinear breakdown characteristics short air gap arcing horns transmission line surge arresters installed transmission lines fdtd based surge simulations compare breakdown characteristics calculated using proposed techniques measured results validation second example application proposed techniques practical surge analysis confirmed reproduce measured results lightning surges invading air insulated substation case direct lightning strike nearby transmission line tower taking account lightning induced voltages arising lightning current flowing lightning channel transmission line tower commonly ignored conventional circuit theory based simulations multiphase back flashover phenomena effect applied voltages
mortality morbidity attributed asthma remains biggest nightmare worldwide hence study aimed compare cardio metabolic risk factors assessed body mass index bmi waist hip ratio whr serum triacylglycerol uric acid well controlled poorly controlled asthmatics correlate parameters severity asthma case control study conducted subjects segregated well controlled asthmatics poorly controlled asthmatics diagnosed based global initiative asthma management guidelines healthy volunteers centrifuged fasting venous blood samples used biochemical analysis pulmonary function test bmi waist hip ratio whr measured statistical analysis done using spss version significant increase bmi whr lipid profile serum uric acid decrease forced expiratory volume fev forced vital capacity fvc fev fvc poorly controlled asthmatics significant association fev serum uric acid bmi triacylgycerol poorly controlled asthmatics poorly controlled asthmatics greater risk developing cardiometabolic problems serum uric acid used one severity markers asthma assess cardio metabolic risk
derivation input sequences distinguishing states finite state machine fsm specification well studied context fsm based functional testing present three heuristics derivation distinguishing sequences nondeterministic fsm specifications first based cost function guides derivation process second genetic algorithm evolves population individuals possible solutions input sequences using fitness function crossover operator specifically tailored considered problem third heuristic mutation based algorithm considers randomly generated input sequence candidate solution candidate distinguishing sequence algorithm tries find solution appropriately mutating considered candidate experiments conducted assess performance considered algorithms respect execution time virtual memory consumption quality length obtained sequences experiments conducted using randomly generated machines various number states inputs outputs degrees non determinism assess impact varying number states inputs outputs degree non determinism elsevier rights reserved
although aesthetic preferences known important person perception play significant role everyday social decisions effect age observer aesthetic preferences faces different ages yet fully investigated present study investigated whether aesthetic preferences change aging age related bias favoring faces one age group addition examined role age perceptual qualities social attributes faces may influence aesthetic judgements younger older adult observers provided ratings images younger middle aged older unfamiliar faces well attractiveness rating dimensions included perceptual distinctiveness familiarity social competence trustworthiness dominance factors results suggested consistent aesthetic preference youthful faces across ages observers surprisingly evidence age related bias attractiveness ratings older adults tended provide higher ratings attractiveness competence trustworthiness unfamiliar faces consistent positivity effect previously reported also tested whether perceptual factors face familiarity distinctiveness affected aesthetic ratings ratings familiarity distinctiveness positively associated attractiveness faces moreover ratings familiarity decreased increasing age face regard social characteristics faces found age face negatively correlated ratings trustworthiness provided observers competence ratings older observers interestingly older adults provided higher ratings perceived competence trustworthiness younger older faces however results also suggest higher attractiveness ratings together older aged faces led positive evaluations competence results discussed within context age related decline differentiation faces memory findings important implications better understanding age related perceptual factors cognitive determinants social interactions unfamiliar others across adult lifespan
compared total water use livestock production systems water livestock drinking small amount important requirement health productivity animals study carried assess constraints challenges meeting drinking water requirements livestock rural mixed smallholder crop livestock farming districts ethiopian rift valley area data collected individual interviews randomly selected respondents farmer group discussions farmers ranked feed water scarcity two important constraints livestock husbandry although ranking order differed districts villages poor quality water concern communities proximity urban settlements industrial establishments water provision livestock challenging dry season since alternative water sources dried polluted though rainwater harvesting dugout constructions practiced cope water scarcity farmers indicated mismanagement harvested water posing health risks livestock people sustainable water provision livestock area thus depends use different water sources intermittent perennial properly managed industrial establishments adopt environment friendly production minimize pollution water resources used livestock consumption technical support farmers required proper design use existing rainwater harvesting systems investigations recommended effect poor quality water perceived farmers performance livestock
objective collectively assess consumer attitudes towards satisfaction emergency contraception counselling student pharmacists two different locations academic healthcare clinic retail pharmacy methods counselling provided trained student pharmacists utilizing standardized education toolkit participants asked rate counselling end knowledge survey addition descriptive statistics compared self reported attitudes satisfaction counselling two sites key findings majority participants settings rated strongly agree attitude satisfaction statements counselling participants clinic setting rated higher two four statements participants retail setting conclusions participants positive attitudes towards highly satisfied counselling settings counselling encouraged practice settings
immigrant refugee women diverse ethnic backgrounds encounter multiple barriers accessing mental healthcare various settings systematic review prevalence mental health disorders among culturally linguistically diverse cald women australia documented following barriers logistical language communication dissonance participants care providers preference alternative interventions article proposes recommendations policies better address mental health needs immigrant refugee women key policy recommendations include support gender specific research implementation evaluation transcultural policies cultural responsiveness service delivery review immigration refugee claims policies social integration immigrants
recent studies revealed fibroblast like synoviocytes fls pivotal effector cell inflamed joint rheumatoid arthritis patients fls exhibit high proliferation rates constitutive expression cytokines contributing pathogenesis study found expression tripartite motif containing protein trim candidate tumor suppressor gene lower synovial tissue samples patients healthy controls investigated role trim proliferation cytokine secretion primary cultured fls patients enforced expression trim fls led significantly decreased cell proliferation indicated cell counting kit assay reduced secretion tumor necrosis factor alpha tnf alpha interleukin beta indicated enzyme linked immunosorbent assays decreased phosphorylation assessed western blot analysis proteins promoting cell cycles cyclin pcna downregulated protein negatively regulating cell cycle progression upregulated trim overexpression importantly trim knockdown reverse effects cell proliferation suppressed specific inhibitor conclusion current results demonstrated downregulation trim expression synovial tissues importantly trim exerted anti proliferation role fls via signaling pathway
purpose study examine compare teaching behaviour female male preschool teachers concerning teaching style emotional support support exploration gender typed activities additionally study tested association gender roles femininity masculinity teaching styles emotional support provided opportunities exploration results indicated four teaching styles male teaching styles often emotionally reserved comparison female ones female teachers offered often verbal physical emotional support compared male teachers gender differences found regarding support exploration general female teachers offered female gender typed activities compared males warmth support males teaching style positively related femininity psychological pressure males teaching style negatively related masculinity
new compact scheme developed non uniform grid compact scheme developed spatial discretization analyzed conjunction four stage fourth order runge kutta scheme time integration solving one dimensional convection equation space time discretization combination calibrated subjecting system global spectral analysis gsa developed authors group compact scheme obtained using combination two diagonal schemes novel aspect scheme application physical plane directly without necessity mapping transformations typical cases problems acoustics well fluid mechanics studied potential use large eddy simulations les demonstrated solving navier stokes equation lid driven cavity elsevier inc rights reserved
aimby investigating association urodynamics urogenital nerve growth factor ngf levels vaginal mesh surgery may able associate likelihood postoperative lower urinary tract symptoms developing result synthetic mesh implanted pelvic floor reconstructive surgery methodsthirty eight female sprague dawley rats divided three groups mesh sham mesh control urodynamic study ngf analysis urogenital tissues done results compared among groups urodynamic studies mesh sham groups divided days value considered statistically significant resultsall rats survived complications observed post implantation period histological evaluation showed intense acute inflammatory reaction days mesh sham groups compared control mesh group showed larger area inflammation compared sham ngf levels increased significantly mesh sham groups days compared control respectively mesh sham groups shorter voiding interval lower voiding volume days compared control group respectively magnitude increasing ngf level decreasing voiding interval voiding volume significantly mesh group sham group conclusiona higher level ngf early days post transvaginal mesh implantation associated shorter voiding interval smaller bladder capacity represents abnormal lower urinary tract symptoms following transvaginal mesh implantation
demonstrated ivf icsi results perinatal outcomes cost effectivity patients advanced age tertiary centre total patients categorised two groups according age group years group years analysed retrospectively addition subgroup analysis performed according years cut clinical pregnancy rate significantly different groups preterm delivery gestational week low birth weight significantly higher advanced aged women youngsters mean expense per cycle hormonal stimulation ivf icsi usd groups respectively mean expense per pregnancy usd groups respectively study showed perinatal outcomes cost effectivity might adversely affected increasing age
iec standard developed allow modeling design distributed control systems providing advanced concepts software engineering abstraction encapsulation world control engineering introduction standard already existing control environments poses challenges since programs written using widespread iec programming standard directly executed fully iec environment without reengineering effort order solve problem paper presents architecture integrate modules two standards allowing exploitation benefits proposed architecture based coexistence control software two standards modules written one standard interact particular interfaces encapsulate functionalities information exchanged standard particular architecture permits utilize available run times without modification allows reuse software modules utilizes oxisting features standards methodology integrate iec modules iec distributed solution based architecture also developed described via case study prove feasibility benefits experimental results demonstrate proposed solution add substantial load delays system compared iec based solution acting task period achieve performances similar iec solution elsevier rights reserved
water treatment flocculation creates aggregated particles flocs large enough removed downstream processes sedimentation filtration fluidized beds flocs floc blankets sometimes included upflow sedimentation processes significantly improve sedimentation tank particle removal plate tube settlers used overall performance sedimentation tank containing floc blanket influenced characteristics incoming flocs fromthe flocculator floc blankets provide additional opportunity aggregation colloidal particles enables reduction size flocculators improving particle removal efficiency study laminar flow flocculators varying velocity gradient residence time theta tested laboratory scale water treatment systemwith floc blanket results indicate increasing range decreasing residence time maintaining constant theta similar improved particle removal results indicate velocity gradients greater existing design recommendations may used reduce flocculator residence times associated construction costs upflow sedimentation floc blanket overlying lamellar plate tube settlers employed subsequent flocculation reduction residence time resulted settled water turbidity nephelometric turbidity unit ntu varying theta constant apparentminimum settled effluent turbidity ntu observed middle residence time tested theta suggesting long hydraulic flocculator residence times may suboptimal
study energy dispatch power distribution networks pdns coupled urban transportation networks electricity demand charging swapping facility influenced arrival rates charging requests electric vehicles depends spatial distribution traffic flows entire transportation system consider impact road congestion route choices vehicles system level perspective traffic flow pattern steady state characterized wardrop user equilibrium consider pdn load perturbation caused traffic demand uncertainty propose robust dispatch method maintains feasibility alternating current power flow constraints applying convex relaxation nonlinear branch power flow equations proposed model yields two stage robust convex optimization problem implicit uncertainty set moreover decomposition framework proposed first phase determines uncertainty set electricity demand solving two traffic assignment problems associated extreme scenarios second phase solves two stage robust second order cone program following delayed constraint generation framework several issues regarding scalability conservatism elaborated case studies corroborate applicability efficiency proposed method
article draws analogy physical nonverbal gesture textual conventions new social media argue vital nonverbal functions face face communication absent digital media communicative functions typically enacted nonverbally transposed new spaces interaction afforded synchronous near synchronous textual media digital social media text conversational text fulfills phatic needs typical social interaction keeping touch way constitute cultural regression represents fundamental ground human cognition inescapably social technologically dependent analysis examples popular microblogging service twitter serves illustrate gestural functions digital media text including enactment mediated social spaces closing section explores theoretical implications identity agency connecting embodied nonverbal communication digital media communication often erroneously understood implicitly approached disembodied
paper introduces new active element combining useful features differential voltage dual first generation current conveyors new proposed active element utilized introduce new generalized filter topology employing grounded components proposed single active element based topology benefits first order second order filter realization appropriate impedance specialization circuit topology single current input provides two output currents voltages case thorough study proposed active element along extensive simulations carried validate filter topology detailed non ideal study also given support usefulness filter topology higher order filters also realized new active element new filter structure provide advancement existing knowledge scope active element exploited analog signal processing applications general proposed differential voltage dual first generation current conveyor dxcci filtering applications simulated using tsmc technology
determining relevance services intelligent environments critical step implementing reliable context aware ambient intelligent system designing provision explicit indications system effective communicating relevance however explicit indications come cost user cognitive resources work strive create novel pathway implicit communication user ambient intelligence employing user stress feedback pathway intelligent system addition following recent works propose using proven laboratory stressors collect ground truth data stressed states present results preliminary pilot study shows promise creating implicit channel communication well proves feasibility using laboratory stressors reliable method ground truth collection stressed states
dielectric barrier discharge dbd excimer lamps efficient environmentally friendly sources ultraviolet one challenges technology massively adopted optimization effective management overall lamp supply system accordingly methodology study impact operating point performance operation dbd excilamp developed experimentally validated dbd operating point parametrically adjusted means power supply current three independent variables intensity frequency duty cycle methodology allows determination optimal operating point particular excilamp study supplying conditions later achieved means dedicated electrical generator especially designed according specifications found increment current intensity positive impact lamp efficiency also leads existence filamentary discharges also relation energy pulse supplied dbd reactor efficiency established certain levels power energy savings reactor higher attained proper selection operating point
consider random walks associated conductances delaunay triangulations gabriel graphs skeletons voronoi tilings generated point processes suitable assumptions point processes conductances show almost realization point process random walks recurrent transient results hold large variety point processes including poisson point processes matern cluster matern hardcore processes clustering repulsive properties order prove state general criteria recurrence transience apply random graphs embedded elsevier rights reserved
goals goals study investigate postprandial distress syndrome pds epigastric pain syndrome eps gastric electrical activity gastric emptying time together circulating concentrations motilin somatostatin corticotrophin releasing factor neurotensin establish whether genetic variability neurotensin system genes differs categories functional dyspepsia background current classification based symptoms proven completely satisfying high degree symptom overlap subgroups study gastric electrical activity evaluated cutaneous electrogastrography time octanoic acid breast test circulating concentrations gut peptides measured radioimmunoassay nts ntsr snps evaluated pcr endonuclease digestion results fifty four patients female male studied using symptom questionnaire patients classified pds eps although overlap symptom profiles subgroups recorded electrogastrographic parameters postprandial instability coefficient dominant frequency dominant power power ratio significantly different subgroups whereas time differ significantly addition eps characterized different gut peptide profile compared pds finally neurotensin polymorphism shown associated neurotensin levels evidence deserves studies consideration analgesic role neurotensin conclusions analysis gut peptide profiles could represent interesting tool enhance diagnosis overcome limitations due distinction based solely symptoms
glassy carbon foams produced pyrolysis process using polyurethane foam layer phenolformaldehyde resin precursor pyrolysis process conducted vacuum conditions inverted perpendicular pyrolysis conditions determined basis carried thermogravimetric analysis basic mechanical properties like compressive strength carbon foams measured compared theoretical value furthermore glassy carbon foams applied skeleton reinforcement epoxy resin matrix composites analysis mechanical properties revealed values hardness compressive strength materials spatial carbon foam almost two times higher pure matrix applied reference material major factors influenced final mechanical properties quality obtained foams amount carbon material volume moreover proved application carbon foam low mechanical properties led significant increases compressive strength composite materials
interpersonal accuracy correlates modestly across different domains although research explored factors predict accuracy within specific domains interpersonal judgment social attributes whether variables might predict interpersonal accuracy generally across different domains remains question subjective socioeconomic status ses recently emerged important moderator various social cognitions contextual focus empathic accuracy moreover people lower ses tend show greater interpersonal engagement attention thus wondered whether individuals lower subjective ses might exhibit superior interpersonal accuracy multiple domains indeed across four studies found subjective ses inversely correlated accuracy three different domains interpersonal accuracy social attributes situational affect emotion findings therefore demonstrate subjective ses may predict broad interpersonal accuracy abilities suggest despite modest relationships different types first impression accuracy correlates accuracy still operate across domains
control digital transactions steadily risen recent years extent puts question internet traditional openness investigate origins effects change paper formally models historical evolution digital control model economy wide features digital space emerge result endogenous adaptation evolution users preferences culture platform designs technology model shows digital economy exist two stable cultural technological equilibria one intrinsically motivated users low control purely extrinsically motivated users high control opening internet commerce emergence low control intrinsic motivation equilibrium favored specific set norms values formed early culture networked environment opening internet commerce indeed cause transition high control extrinsic motivation equilibrium even latter pareto inferior although early say whether transition actually taking place results call great deal attention evaluating policy proposals internet regulation
paper describes application quasi oppositional harmony search qohs algorithm design scaling factor based fuzzy classical controller pid frequency power control isolated hybrid power system ihps considered ihps model comprised wind turbine generator diesel engine generator energy storage device superconducting magnetic energy storage smes case traditionally membership functions control rules obtained fuzzy logic controllers flcs trial error method obtained based experiences designers optimized traditional optimization techniques extra computational cost overcome problems flcs classical controllers integrated paper flc qohs algorithm applied simultaneously tune sfs tunable parameter flc gains classical controllers tunable parameters smes device minimize frequency power deviations studied ihps system various load demand wind change different considered controller configurations ihps based flc termed fuzzy based flc proportional integral named fuzzy controller based flc proportional derivative abbreviated fuzzy controller based flc proportional integral derivative pid designated fuzzy pid controller simulation results explicitly show performance fuzzy pid controller based ihps superior fuzzy fuzzy fuzzy controller based ihps configuration terms overshoot settling time proposed fuzzy pid controller robust various wide range load changes elsevier rights reserved
background problem solving core ability nursing students develop education need better understand importance problem solving factors related among nursing students objectives study aimed identify role ego resiliency relationship social anxiety problem solving ability korean nursing students methods data collected total nursing students enrolled three nursing programs south korea using self administrated questionnaire data mainly analyzed baron kenny three step regression analysis sobel test results ego resiliency played partial mediating role relationship social anxiety problem solving ability sobel test suggested mediating effect ego resiliency relationship social anxiety problem solving conclusions enhance problem solving ability nursing students nursing educators establish educational strategies decrease social anxiety improve ego resiliency elsevier ltd rights reserved
paper presents approach aimed mining new type pattern data namely analogical proportions analogical proportion expresses equality relationships attributes two pairs structured objects notion investigated database context discovery different forms parallels pairs tuples first give formal definition analogical proportion setting relational databases focus problem mining analogical proportions propose use clustering approach enumerating parallels occurring relation thus discovering analogical proportions
background aims abnormalities thyroid function commonly seen chronic kidney disease ckd patients associated adverse clinical conditions atherosclerosis endothelial dysfunction inflammation abnormal blood pressure variability investigated association thyroid disorders endothelial function assessed flow mediated dilatation fmd carotid intima media thickness cimt cardiovascular events cve ckd patients materials methods observational cohort study included ckd stages patients routine biochemistry including free free thyroid stimulating hormone fibroblast growth factor fgf fmd cimt measured divided patients four groups according thyroid hormone status euthyroidism subclinical hyperthyroidism subclinical hypothyroidism euthyroid sick syndrome fatal composite cve recorded median months results patients subclinical hypothyroidism higher prevalence hypertension diabetes also likely higher values systolic cimt phosphorus intact parathormone ipth fgf homeostasis model assessment insulin resistance lower levels fmd euthyroid patients unadjusted survival analysis subclinical hypothyroidism euthyroid sick syndrome associated increased risk outcome compared euthyroidism hazard ratio confidence interval respectively effects subclinical hypothyroidism euthyroid sick syndrome maintained even fully adjusted models conclusion demonstrated subclinical hypothyroidism euthyroid sick syndrome associated increased cve ckd patients studies needed explore issues
paper explores design ultra light weight power torque dense motor enhance performance light weight electric racing vehicle racing vehicle compete formula student racing events state art powertrain vehicles axial field machines medium speed radial field machines gear paper concerns high speed traction machine radial field design closely considers endurance duty cycle driving cycle race car provides fast acceleration proposed electrical machine designed ultra light weight therefore rpm single gear slot pole brushless highly saturated permanent magnet machine designed active mass around similar account various race events velocity racing tracks closely matched machine output characteristics within paper design load results presented near future following extended tests machine integrated specifically designed single stage gear used drive vehicle using torque vectoring four wheels expect result significant performance gain acceleration endurance handling characteristics university racing eindhoven race vehicle
objectives aim study retrieve data characteristics profile women attending emergency service receive prescription mandatory may emergency contraception methods retrospective study following data collected women requesting january june demographic characteristics time unprotected sexual intercourse usi arrival time last menstrual period usi type prescribed prospective study starting january questionnaire administered requesting following information reasons requiring previous use source knowledge prior contraception age first intercourse results whole study period women requested mean age years italian unmarried still studying high school education reached within usi usi days menstrual cycle levonorgestrel prescribed women ulipristal acetate prospective part study women majority requested condom rupture reported previous use received information subject friends vast majority reported prior use contraception reason using absence relationship conclusion exact profile women requesting help women choice permanent contraception help clinicians counselling women appropriate contraception
quest high performance flexible circuits call scaling minimum feature size thin film transistors tfts although reduced channel lengths guarantee improvement electrical properties devices proper design rules also play crucial role minimize parasitics designing fast circuits letter systematic computer aided design simulations guided fabrication high performance flexible operational amplifiers opamps logic circuits based indium gallium zinc oxide tfts particular performance improvements due use additional third metal layer interconnections estimated first time encouraged simulated enhancements resulting decreased parasitic resistances capacitances tfts circuits realized free standing thick polymide foil using three metal layers despite thicker layer stack tfts shown mechanical stability bending radii moreover opamps logic circuits yielded improved electrical performance respect architecture two metal layers gain bandwidth product increased first one propagation delay decreased latter one
heritable profibrotic differentiation lung fibroblasts key mechanism idiopathic pulmonary fibrosis ipf mechanisms yet fully understood study individual data four independent microarray studies comparing transcriptome fibroblasts cultured vitro normal total ipf total human lung compiled meta analysis following normalization scores one hundred thirteen transcripts upregulated downregulated ipf fibroblasts using significance analysis microrrays algorithm false discovery rate downregulated genes highly enriched gene ontology kyoto encyclopedia genes genomes kegg functional classes related inflammation immunity defense response virus influenza tumor necrosis factor tnf mediated signaling pathway interferon inducible absent melanoma aim inflammasome well apoptosis although upregulated genes enriched functional class select factors known play key roles lung fibrogenesis overexpressed ipf fibroblasts notably connective tissue growth factor ctgf serum response factor srf supporting role drivers ipf full data table available supplement
objective analyze symptomatic treatment patients multiple sclerosis background multiple sclerosis chronic inflammatory disease central nervous system accumulating disability symptoms like spasticity voiding disorders depression pain might occur material methods nationwide german registry initiated guidance german society deutsche gesellschaft study performed interim analysis lay foundation future work topic subcohort patients assessed interim analysis mean age patients years mean edss two third enrolled patients females results frequent symptoms fatigue followed spasticity voiding disorders likelihood treatment highest epileptic disorders spasticity pain depression multivariate regression analysis showed retirement strongest factor predictive antispastic treatment beta conclusion almost patients analysis suffer symptoms due advanced treatment various symptoms differed tremendously likelihood treatment correlated availability effective therapeutic agents clinicians put awareness symptoms symptomatic treatment may improve quality life
manga type graphic novel represent widely popular literary genre worldwide one fastest growing areas publishing arena aimed adolescents united states however knowledge almost empirical research examining content effects reading manga article consists studies study represents content analysis aggressive behavior best selling manga aimed adolescents results revealed aggression common often portrayed ways may influence subsequent behavior study examined relationship reading manga aggressive behavior adolescents manga readers physically aggressive non manga readers also reported peer relationships lonely individuals smaller groups addition reading manga particularly high levels aggression associated physical aggression even controlling media violence exposure media implications regarding findings discussed
new enveloped following method based high order obreshkov integration formula presented new method suitable transient analysis highly oscillatory circuits widely separated time scales addition proposed algorithm capable producing high order numerically stable approximation transient response use high order formulas leads significant reduction computational time compared low order methods allows taking large steps time keeping accuracy
tetrahydroprotoberberines thpb high affinity dopamine receptors may provide novel treatment drug addiction assessed effects thpb govadine acquisition expression extinction reinstatement amphetamine induced conditioned place preference cpp furthermore effects govadine conditioned association contextual stimuli natural reward examined using food induced cpp separate experiments rats received govadine amphetamine injection conditioning expression amphetamine induced cpp extinction session amphetamine induced reinstatement cpp ore placement compartment containing food conditioning although govadine effect acquisition amphetamine cpp treatment govadine acquisition dose dependently extinguished preference amphetamine associated context quickly vehicle treatment moreover govadine treatment facilitated extinction amphetamine cpp given repeatedly throughout extinction phase although expression amphetamine cpp affected govadine administered prior expression test amphetamine induced reinstatement cpp following extinction period blocked govadine intermediate dose govadine blocked acquisition food cpp whereas high dose facilitated extinction preference compared vehicle treated animals therefore govadine attenuates maintenance conditioned associations contextual stimuli amphetamine food reward well amphetamine induced reinstatement drug seeking behaviour govadine may candidate development pharmacological treatment psychostimulant drug dependence elsevier rights reserved
recovery valuable metals complex sulfide concentrates investigated via chlorination roasting followed water leaching reaction process proposed basis previous studies results preliminary experiments process various process parameters studied including roasting temperature addition nhcl roasting time leaching time liquid solid ratio roasted products leach residues characterized ray diffraction vibrational spectroscopy optimum condition recovered addition removal iron studied water leaching stage results demonstrate process provides effective approach extracting multiple metals complex concentrates ores
buildings consume large amounts energy resources significant impact environment buildings accounted total global final energy use energy related ghg emissions energy use related emissions may double potentially even triple mid century china world largest energy consumer emitter process urbanization china entering period great prosperity construction billion buildings constructed year accounts world total new buildings predicted china building energy use related emissions continue increase next years therefore promoting green building development become urgent issue china however green building highly complicated system engineering promotion needs evaluation standards technical support marry countries issued series green building evaluation standards since currently representative green building assessment schemes code sustainable homes csh fully implemented national authoritative standard since leadership energy environmental design leed developed usa revised updated regularly latest version issued china enacted national evaluation standard green building revised standard based introducing latest evaluation standards green buildings china britain united states paper compared standards aspects including energy saving water saving material saving site selection outdoor door environmental quality comparison mainly focuses evaluation methods evaluation indicators three standard systems besides characteristics standard system summarized suggestions improving china evaluation standard green building proposed
social cognition topic enormous interest much research far agreed taxonomy factor structure relevant processes aim review outline briefly known structure social cognition suggest progress made delineate ter dependence core sociocognitive processes focus particular several processes discussed tested together typical atypical notably autism spectrum disorder groups imitation biological motion empathy theory mind consider domain specificity generality core processes social learning reward attention highlight potential relevance dual process theories distinguish systems fast automatic slow effortful processing conclude methodological conceptual suggestions future progress uncovering structure social cognition
based phenomenon change stress temperature cause elastic volumetric strains concept equivalent stress introduced newly proposed thermoelastoplastic model new concept used formulate equivalent subloading yield surface extended void ratio difference corresponding evolution equation natural way consider influences stress temperature proposed model describe properly general mechanical thermal behavior typical geomaterials confirmed laboratory tests results instance increase temperature may increase decrease strength materials depending characteristics materials meanwhile proved proposed model satisfies thermodynamic theorems framework thermodynamics elsevier ltd rights reserved
seek exact double non traveling wave solutions nonlinear partial differential equations compound expansion method firstly proposed paper aid symbolic computation new method applied construct double non traveling wave solutions dimensional painleve integrable burgers equation dimensional breaking soliton equation result abundant double non traveling wave solutions including double hyperbolic function solutions double trigonometric function solutions double rational solutions series complexiton solutions two equations obtained via proposed method exact solutions contain arbitrary functions may helpful explain complex phenomena parameters taken special values double solitary like wave solutions derived double hyperbolic function solutions furthermore time evolutions double solitary like wave solutions discussed detail elsevier ltd rights reserved
pulmonary fibrosis serious medical problem may significantly compromise respiratory functions aim work study effect linagliptin calcipotriol bleomycininduced pulmonary fibrosis explore possible mechanisms underlying effect one hundred twenty male cbl mice divided equal groups follows control group bleomycin group bleomycin carboxymethylcellulose group bleomycin linagliptin group bleomycin calcipotriol group bleomycin linagliptin calcipotriol group lung weight body weight index lung tissue hydroxyproline collagen toll like receptor tlr nuclear factor like nrf heme oxygenase malondialdehyde mda glutathione peroxidase gpx catalase cat measured also bronchoalveolar lavage fluid balf analyzed total differential leucocytic count lactate dehydrogenase tumor necrosis factor alpha tnf interleukin transforming growth factor beta tgf vascular response potassium chloride phenylephrine carbachol well tracheal response carbachol measured also lung tissue subjected histopathological immunohistochemical examination administration linagliptin calcipotriol induced significant decrease lung weight body weight index total leucocytic count balf lactate dehydrogenase activity tnf tgf associated significant decrease lung tissue mda nrf tlr hydroxyproline collagen content significant increase tissue gpx cat improvement pulmonary architecture vascular tracheal response compared bleomycin group effects significant linagliptin calcipotriol combination group compared use drugs alone conclusion linagliptin calcipotriol combination may represent effective therapeutic modality amelioration bleomycin induced pulmonary fibrosis elsevier rights reserved
carbon nanotubes cnts nanomaterials attracted great research interest unique properties promising applications controllable synthesis cnts precondition broad application review consider nanoscale process engineering assess recent progress mass production ultra long inexpensive cnts good alignment well tunability wall number diameter fundamental engineering science applications across multiple scales cutting edge nanoscale process engineering research areas physics chemistry materials engineering ecology social science allow obtain high added value multi functional advanced cnts synthesis cnts controllable chirality good alignment predetermined sizes lengths still presents great challenges multidisciplinary scientific research advanced cnt based materials promote development sustainable society
dialectics exist economic development environmental protection social needs urbanization process however dialectics seldom explored building level dialectics sustainable building denote interdependence among elements complex socio technical systems paper aims examine dialectics drawing dialectical systems theory research carried case study three real life projects china witnessed rapid urbanization process also set ambitious targets promotirig multifaceted interwoven dialectics observed concept methodology value dimensions systems thinking found help recognize dialectics strategies could synergize synthesize elements dialectical systems effective managing dialectics sbs studied considered complex socio technical systems embedded social political geographic contexts led varied articulations dialectics findings contribute contextual factor dialectical systems approach solutions delivering sbs need customised order best address specific dialectics elsevier ltd rights reserved
various applications like instance algorithm design mission planning geo referencing change detection automatic target recognition atr sar data analysis rely simulated synthetic aperture radar sar images however different sar simulation techniques different advantages disadvantages depending needs certain application suitable sar simulation technique used paper compares three sar image simulation approaches raysar cohras sarviz showing similarities differences raysar cohras two ray tracing based sar image simulators raysar based open source software pov ray cohras developed sar simulator scratch third simulator sarviz real time sar simulator based rasterization approach geometrical features three simulators compared differences different applications analyzed authors published elsevier behalf international society photogrammetry remote sensing inc isprs open access article license
previous research relationship executive function source monitoring young children inconclusive studies finding conflicting results whether working memory inhibitory control related source monitoring ability study role working memory inhibitory control recognition memory source monitoring two different retrieval strategies examined children aged participated science activities two sources later given recognition source monitoring test completed measures working memory inhibitory control source monitoring test half participants asked sources serially one whereas half children asked sources parallel considering sources simultaneously results demonstrated working memory predictor source monitoring accuracy conditions inhibitory control related source accuracy parallel condition age controlled relationships longer significant suggesting general cognitive development factor stronger predictor source monitoring executive function alone interestingly children aged years made accurate source decisions parallel condition serial condition older children aged overall accurate younger children accuracy differ function interview condition suggestions provided guide research area clarify diverse results previous studies examining whether executive function cognitive prerequisite effective source monitoring
alzheimer disease common form dementia aged people defined two pathological characteristics beta amyloid protein beta deposition tau hyperphosphorylation although mechanisms development still debated series evidence supports idea metals copper iron zinc magnesium aluminium involved pathogenesis disease particular processes beta deposition senile plaques inclusion phosphorylated tau neurofibrillary tangles nfts markedly influenced alterations homeostasis aforementioned metal ions moreover mechanisms oxidative stress synaptic plasticity neurotoxicity autophagy apoptosis mediate effects metal ions induced aggregation state beta phosphorylated tau development importantly imbalance mechanisms finally caused cognitive decline different experiment models collectively reconstructing signaling network regulates progression metal ions may provide novel insights developing chelators specific metal ions combat elsevier rights reserved
ferritic martensitic dual phase steels deform spatially highly heterogeneous manner strong strain stress partitioning micro scale heterogeneity local strain evolution leads turn spatially heterogeneous damage distribution thus plays important role process damage inheritance fracture understand improve steels important identify connections observed strain damage heterogeneity underlying microstructural parameters ferrite grain size martensite distribution martensite fraction etc work pursue aim conducting situ deformation experiments two different steel grades employing two different microscopic digital image correlation dic techniques achieve microstructural strain maps representative statistics high resolution resulting local strain maps analyzed connection observed damage incidents identified image post processing local stress maps obtained crystal plasticity simulations microstructural area results reveal plasticity typically initiated within hot zones larger ferritic grains lower local martensite fraction increasing global deformation damage incidents often observed boundary highly plastified zones high resolution dic corresponding simulations reveal importance martensite dispersion zones bulky martensite susceptible macroscopic localization full strain hardening capacity material consumed overall presented joint analysis establishes integrated computational materials engineering icme approach designing advanced steels elsevier ltd rights reserved
classification plays critical role false positive reduction fpr lung nodule computer aided detection cad achieve effective recognition nodule many machine learning methods proposed however multiple heterogeneous feature subsets high dimensional irrelevant features well imbalanced distribution nodule non nodule classes typically makes problem challenging solve challenges proposed multi kernel based framework feature selection imbalanced data learning lung nodule cad involving multiple kernel learning ezi norm regularizer heterogeneous feature fusion selection feature subset level multi kernel feature selection based pairwise similarities feature level multi kernel sampling imbalanced data learning experimental results demonstrate effectiveness proposed method terms geometric mean mean area roc curve auc consistently outperform competing methods
children born assisted reproduction tecniques exposed high doses hormones intrauterine period long term health status children exposed high doses hormones especially early prenatal development known however discussed children may risk low birth weight prematurity high blood pressure high blood glucose precocious puberty five subjects born low birth weight using assisted reproduction techniques diagnosed premature puberty presented draw attention relation prenatal exposure hormones precocious puberty turk arch ped
background ability athletic shoes enhancing athletic performance attributed elastic energy storage recovery cushioning system however much remains unclear efficacy wearing athletic shoes influence athletic shoes knee joint biomechanics aim study investigate effects wearing athletic shoes kinematics kinetics knee joint four different athletic movements including walking running jumping sidestepping hypothesis effect athletic shoes knee biomechanics would differ depending type movements methods knee joint kinematics kinetics walking running jumping sidestepping assessed barefoot shod conditions nineteen healthy recreational athletes participated study three dimensional joint force joint angle joint moment calculated using three dimensional motion analysis system variables evaluated study included time stance phase velocity movement ground reaction force peak joint angles peak joint moments sagittal frontal transverse planes biomechanical variables compared barefoot shod conditions using paired test results amplitude velocity ground reaction force significantly greater shod walking running sidestepping knee flexion angle significantly greater shod walking running jumping knee flexion moment significantly greater shod walking running abduction angle abduction moment external rotation moment significantly greater shod sidestepping conclusions athletic footwear changes kinematics kinetics knee joint walking running jumping sidestepping effects athletic footwear knee joint motion vary depend types athletic movements deeper understanding humans adapt altered properties foot ground interface different movement tasks may enhance knowledge mechanisms load regulation human motion
development fluvial systems often described modeled terms principles related maxima minima optima various hydraulic energy parameters generally encompassed principle efficiency selection efficient flow routes tend preferentially selected enhanced however efficiency selection highly localized cumulative effects local events may may produce efficient pathways broader scale illustrated case icicle bend shawnee run limestone bedrock stream central kentucky field evidence indicates paleochannel abandoned downcutting stream relocation analyzed using flow partitioning model bend represents abandonment steeper straighter efficient channel reach scale favor longer currently less steep less efficient flow path apparently occurred owing capture shawnee run flow subsurface karst flow path subsequently exhumed development icicle bend illustrates local nature efficiency selection role historical contingency geomorphic evolution elsevier rights reserved
nonwoven fabric widely used geotextile engineering recent years tensile strength important behaviour since fibre distributions nonwoven fabrics random discontinuous unit cell model nonwoven fabric developed simulate tensile behaviour article presents research using finite element method fem study tensile behaviour nonwoven fabric macro scale based classical laminate composite theory laminate orientation considered orientation distribution function fibres obtained analysing data acquired scanning electron microscopy hough transform model nonwoven fabric developed using abaqus software required engineering constants nonwoven fabric obtained experimental data finally nonwoven specimens stretched along machine direction cross direction experimental stress strain curves compared results simulations approximate agreement proves validity model could used precisely simulate stress relaxation strain creep bending shear property nonwoven fabric
large set decimetric microwave observations solar millisecond radio spikes compared correlated simultaneous hard ray observations kev range recorded hard ray burst spectrometer hxrbs board solar maximum mission satellite radio spikes time scales hard ray bursts rarely show fine structures shorter main conclusions statistical analysis association rate correlation degree relative time delays hard ray radio spike emissions radio spike bursts reveal highest hard ray association rate kind coherent solar radio emission approximately observed events occur mostly impulsive hard ray bursts conversely almost equal hxrbs flares produce radio millisecond spike bursts spike bursts preferentially associated impulsive phase hard ray event half observations closely associated main peak simultaneous ray event find significant temporal correlation spike clusters hard ray events compared events show hard ray time profiles mimic concentration simultaneous radio spikes also holds small fluctuations time scales order seconds durations spike events associated hard ray bursts closely correlate ray bursts somewhat longer radio events radio emission usually delayed respect hard ray bursts typically seconds relative delays seem restricted following rules radio event usually starts peak time hard ray event cases similarly ray burst almost always starts maximum spike burst activity cases shown hold wide range burst durations found convincing relation concerning relative time differences end times however observed delays order several seconds put constraints acceleration propagation particles delays found incompatible build time loss cone distribution maser emission order magnitude population electrons responsible radio ray radiation rather considering smallness radio spike sources proportionality ray flux spike rate spatial spread propagating electron population argued time delays quantization discrete radio events caused operation accelerator
global environmental pollution fossil energy shortage problems getting increasingly serious renewable energy sources res drawing attention china res experiencing rapid development however randomness res volatility power output energy storage technology needed chip peak fill valley promoting res utilization economic performance speak energy storage precondition large scale integration consumption res however china energy storage industry exploration stage far commercialization restricts development res certain extent reason paper concentrate china energy storage industry first summarizes developing status energy storage industry china paper analyzes existing problems china energy storage industry aspects technical costs standard system benefit evaluation related policies finally solutions proposed based problems promote sound development china energy storage industry
asp located server side scripting running environment kind environment user able create run dynamic interactive web server application interactive dynamic web page web information processing web database access analysis asp technology access characteristics web database paper introduces working principle asp asp built objects components emphasizes discuss asp database access components ado based gives realization asp web database access application example manufacturing engineering
recent years number papers treated problem finite time stability stabilization impulsive general switching dynamical linear systems generally works assume sequence switching following resetting times priori known paper remove strong assumption making technique appealing practical control engineering point view first result provided work sufficient condition finite time stability resetting times known certain degree uncertainty condition requires solution suitable feasibility problem based coupled difference differential lmis show uncertainty intervals reduce size condition becomes less conservative becoming necessary sufficient certain case resetting instants perfectly known eventually consider conceptually different situation resetting times totally unknown namely arbitrary switching case analysis results used derive sufficient conditions existence state feedback controllers finite time stabilizes closed loop system three cases mentioned earlier nontrivial example considering finite time control liquid levels three interconnected reservoirs shows effectiveness proposed approach copyright john wiley sons ltd
process priming incidental stimuli environments influence thoughts feelings behaviour may true incidental stimuli online environments adverts websites two experiments showed mere presence advertisements violent content simulated facebook page induced higher levels aggression related cognition comparison non violent adverts subsequent word recognition task participants primed violent stimuli remembered actually unseen violence related words control participants reported recognising violent words actually seen however priming violent adverts effect mood person perception third correlational study examined whether variance extent priming could attributed individual differences aggressiveness participants aggressiveness unrelated scores aggressive cognition measure studies established website adverts violent content could prime aggressive cognitions individuals differed extent experienced priming effect attributable levels trait aggressiveness effects priming found either mood state person perception elsevier ltd rights reserved
aim study determine effects intervention programme based utilisation social learning concept practised social networks among adult women suburban population turkey study performed two disadvantaged neighbourhoods umraniye istanbul one neighbourhoods served intervention control group order document efficacy intervention baseline evaluation surveys carried neighbourhoods widely known hormonal contraceptive method oral contraceptives emergency contraceptives determined least known methods improvement higher least known methods education peer groups shown effective improving knowledge women contraception information transfer peer groups used frequently particularly emergency contraception
jizba arimitsu entropy also called hybrid entropy combines axiomatics renyi tsallis entropy many common properties hand aspects maxent distributions different paper discuss statistical properties hybrid entropy define hybrid entropy continuous distributions relation discrete entropy additionally definition hybrid divergence connection fisher metric also presented interestingly fisher metric connected hybrid entropy differs corresponding fisher metrics renyi tsallis entropy motivates introduce average hybrid entropy understood average tsallis renyi entropy elsevier rights reserved
projection mapping projection technology used turn objects buildings display surface video projection combination sensing technology projection mapping technology interactive performance artistic expression achieved combined technology attracting attention called interactive projection mapping two types interactive performance using projection mapping one performance operation small number people performance lot people simultaneously take part latter requires technology achieve smooth computer graphics video processing enormous number requests audience crowded narrow area kwansei gakuin university conducting performance projection mapping one christmas events since organized large scale interactive performance projection mapping december developed interactive projection mapping system applied performance eventually system realized smooth interactive performance paper present scalable intelligent collaborative architecture large scale interactive projection mapping system show implemented system results performance
paper presents thd audio automatic gain control agc circuits proposed agc based feedback topologies gain digital controlled type resistors network used programmable gain amplifier pga passive feedback device realize gain linearity decibels increase gain accuracy hysteresis comparator eliminate chattering effects output signal peak detector changes rapidly around threshold design implemented cmos occupies active area power consumption agc supply voltage gain pga agc loop ranges step gain error integrated noise audio range similar khz vrms gain set total harmonic distortion thd audio frequencies vpp differential output
computer based control systems especially run general purpose operating systems often exhibit variance scan period processing inputs outputs although fact usually taken account discrete control algorithms used cause worse performance control loop comparison theoretical case paper describe modified discrete control algorithm takes disturbances scan period account partially compensates influence also show controller implemented even low performance hardware platforms equipped sufficient amount memory
environmental sustainability grown importance governments community purpose paper examine environmental sustainability activities reits period global financial crisis using content analysis methodology similar newell annual reports home websites largest reits also constituent asx index analysed determine extent sustainable investment activities green building council australia nabers websites also explored given increasing focus sustainable commercial property study finds reit investment properties rather conservative slow however reits tried lead field even period global financial crisis relatively solid stable returns equity assets appear achieved reits years following crisis
modification classical volume balance models one effective strategies improving design surface irrigation optimal usage water resources agricultural section paper modified volume balance model developed predict advance curve surface irrigation based variable actual depth upstream end furrow simulations suggested structure generated combination different values furrow irrigation variables inflow discharge length furrow infiltration parameters compare different models measured data results show modified volume balance accurate previous equations model efficiency furrow length respectively sensitivity analysis made changing one input parameter including discharge field slope roughness coefficient infiltration parameters time keeping others fixed furthermore inflow rate considerable impact model estimations nevertheless developed model sensitive decreasing inflow discharge amount increasing elsevier rights reserved
introduction modern mental healthcare standards services kingdom saudi arabia ksa resulted gradual shift towards positive perspective mental health issues related services increased demand qualified mental health professionals psychological interventions despite recent advances mental healthcare services psychopharmacology remains main treatment modality majority mental health issues ksa psychotherapy rather slow developmental trajectory ksa provision requires understanding many specific aspects saudi culture dubovsky paper shed light historical development current challenges psychiatric psychological services availability psychotherapy ksa offering explication selection local social phenomena paper attempt explain unique saudi cultural constructs social contexts influence training perception practice psychotherapy country outlining existing challenges well expected future directions
idiopathic interstitial pneumonias comprise clinicopathological entities chronic course various prognosis idiopathic pulmonary fibrosis frequent severe computed tomography important role diagnosis identify corresponding pathological pattern usual interstitial pneumonia percent cases suggest differential diagnosis cases frequently fibrosing nonspecific interstitial pneumonia chronic hypersensitivity pneumonitis imaging features integrated clinical available pathologic data multidisciplinary team meetings involving physicians good knowledge interstitial diseases cases may unclassifiable could later reclassified new data may occur imaging features may change surgical lung biopsy less frequently performed emerging less invasive technique lung cryobiopsy evaluation pleuroparenchymal fibroelastosis distinct entity recently described uncertain prevalence prognosis seems quite often associated another pattern interstitial pneumonia elsevier masson sas rights reserved
contribution deals potential called active knowledge database conjunction agricultural resort authors contribution initially focus attention defining term active databases possible roles expectations associated agriculture czech republic certainly potential initiate qualitative change functioning entire agricultural sector authors also deal possibility creation databases derive principles classical relational databases crucial matters examination relational database technology especially issue database triggers theory measurement evaluation quality software products active database must created principles relational database technology principles must also work proposed principles active databases verified functional prototype generalized basis conclusions specified recommendations significantly increase benefits phenomenon
wind power type clean renewable energy reasonable utilization wind power beneficial environmental protection economic development therefore short term hydro thermal wind economic emission dispatching shtw eed problem presented paper proposed problem aims distribute load among hydro thermal wind power units simultaneously minimize economic cost pollutant emission solve shtw eed problem complex constraints modified gravitational search algorithm based non dominated sorting genetic algorithm iii mgsa nsga iii proposed proposed mgsa nsga iii non dominated sorting approach reference point based selection mechanism chaotic mutation strategy applied improve evolutionary process original gravitational search algorithm gsa maintain distribution diversity pareto optimal solutions moreover parallel computing strategy introduced improve computational efficiency finally proposed mgsa nsga iii applied typical hydro thermal wind system verify feasibility effectiveness simulation results indicate proposed algorithm obtain low economic cost small pollutant emission dealing shtw eed problem elsevier ltd rights reserved
amisulpride substituted benzamide binds selectively dopamine receptors higher affinity limbic compared striatal dopamine receptors vivo low doses amisulpride facilitates dopamine transmission via selective blockade presynaptic receptors amisulpride active antipsychotic compound effective low doses negative symptoms high doses positive symptoms schizophrenia cns profile multiple doses low dosage regimen amisulpride daily days assessed randomised double blind way crossover placebo controlled study carried cut young sleep deprived subjects using eeg various measures psychomotor cognitive functions caffeine slow release used positive reference multiple doses amisulpride daily devoid detrimental effects eeg psychomotor performance cognitive function total sleep deprivation addition amisulpride partially antagonized deleterious effects sleep deprivation eeg subjective sedation shown trends significant increase eeg relative beta power decrease subjective sedation effects pronounced end sleep deprivation suggesting possible alerting effects amisulpride dose level caffeine significantly antagonized detrimental effects sleep deprivation vigilance increase eeg beta waves speed reaction sustained attention reduction subjective sedation conclusion present results demonstrate amisulpride devoid detrimental effects eeg psychomotor cognitive performance sleep deprivation situation well known amplify effects exist moreover data suggest possible alerting effects low dosage regimen amisulpride editions scientifiques medicales elsevier sas
well known initial boundary value problems involving constitutive equations modeling degradation strength materials well posed renders computations questionable overcome issue necessary enhance models incorporating internal length shown enhancement restores objectivity computation spurious mesh dependency avoided however least simple problems one dimensional ones proven uniqueness underlying mathematical problem restored moreover numerical modeling element tests yields several solutions paper demonstrates several numerical solutions obtained also less simple problems namely borehole problems even defect introduced computed problems different numerical solutions found contrary one dimensional problem proof loss uniqueness comes underlying mathematical problem opinion inherent property initial boundary value problems broadly speaking strong degradation mechanical properties modeled case necessary aware issue problems involving constitutive equation modeling strength degradation important try find solutions one obtained using routinely numerical code failure patterns different solutions found however similar experimental observations possible loss uniqueness seen counterpart difficulties encountered attempting reproduce experiments crucial dealing geomaterials elsevier ltd rights reserved
introduction attachment theory widely used order explain anorexia nervosa origin course treatment response nevertheless little literature specifically investigated parental bonding adolescents anorexia well parents bonding intergenerational transmission within family purpose study aims identify specific pattern parental bonding families adolescents newly diagnosed restricting type anorexia comparing families control group patients methods total participants adolescents parents belonging anorexia group control one rated perceived parental styles parental bonding instrument latent class analysis allowed exploration maternal bonding latent variable paternal one results main findings showed careless overcontrolling parental style recalled patients parents particular fathers far adolescents responses concerned patients anorexia seem express differently parental bonding perception participants control group conclusion clinical implications driven results suggest therapeutic intervention working parents attachment representations influence current relationships may help modify actual family functioning thus outcome patients anorexia
background aim weight gain stopping smoking potentially counteracts improvements cardiometabolic risks investigated changes metabolic syndrome mets components homeostasis assessment model insulin resistance homa smokers given dietary counseling quit attempt methods results smokers cigarettes day bmi randomized low carbohydrate low fat diet treated standard course varenicline weeks quitters assessed according russell standard cigarettes quit date validated expired breath carbon monoxide ppm randomized participants completed clinical laboratory assessments weeks changes metabolic risk factors differ dietary groups combined groups compare quitters continuing smokers found similar weight change among validated quitters continuing smokers change waist circumference changes triglyceride concentrations mmol mmol diastolic blood pressure mmhg mmhg favorable quitters changes cardiometabolic risks homa differ quitters continuous smokers energy intake resting metabolic rate conclusion dyslipidemia blood pressure improved early weight gain seen quitters suggesting dietary intervention mitigate effects stopping smoking cardiometabolic risk factors overweight obese smokers italian society diabetology italian society study atherosclerosis italian society human nutrition department clinical medicine surgery federico university published elsevier rights reserved
objective traditional pharmacotherapy undoubtedly improved outcome patients psychiatric disorders partial efficacy poor tolerability persists number subjects among different compounds zonisamide used address unmet needs standard pharmacotherapy purpose present article provide review use zonisamide treatment psychiatric conditions methods research main database sources conducted obtain overview use zonisamide psychiatric disorders associated conditions obesity smoking cessation results available data indicate possible effectiveness zonisamide treatment acute phases bipolar disorder binge eating disorder bed alcohol misuse obesity assessment safety tolerability zonisamide made necessary fact exception bed disorders least data come studies combined pharmacological therapies conclusions zonisamidemay utility especially adjunctive therapy management acute phases weight gain bipolar disorder prevention alcohol misuse preliminary evidence indicates zonisamide candidate compound treatment bed obesity however open label design small sample sizes available studies prevent drawing sound conclusions utility compound psychiatry
background discovery clinical workflows target redesign using methods lean six sigma difficult voip telephone call pattern analysis may complement direct observation emr based tools understanding clinical workflows enterprise level allowing visualization institutional telecommunications activity objective build analytic framework mapping repetitive high volume telephone call patterns large medical center associated clinical units using enterprise unified communications server log file support visualization specific call patterns using graphical networks methods consecutive call detail records medical center unified communications server parsed cross correlate telephone call patterns map associated phone numbers cost center dictionary hashed data structures built allow construction edge node files representing high volume call patterns display open source graph network tool results summary statistics analysis exactly one week call detail records large academic medical center showed calls placed total duration hours approximately half calling called number pairs average call duration seconds average call duration seconds conclusions cross correlation phone calls identified clinical cost center used generate graphical displays clinical enterprise communications many calls short compact data transfers within short calls may serve automation design targets large absolute amount time medical center employees engaged voip telecommunications suggests analysis telephone call patterns may offer additional insights core clinical workflows
reach legislation requires chemicals including petroleum substances put market quantities greater tonnes year tested prenatal developmental toxicity require large numbers animals since prenatal development toxicity testing animal intensive application toxicogenomic technologies might reduce number animals study prenatal developmental toxicity petroleum substances allowing grouping categories toxicological properties substance categorization may supported similarities molecular fingerprints developmental toxicity effects observed oil products likely related polycydic aromatic hydrocarbons pahs high molecular weight however current review indicates even though available studies provide clues regarding hox fox shh pax family genes regulate functions skeleton development single individual genes used biomarkers pahs exposure subsequent prenatal developmental toxicity furthermore considered toxicogenomic technologies applied specific tissues organs testing might lead unreliable results regarding developmental toxicity due induction tissue specific pathways thus approach applies battery vitro tests including zebrafish embryo test embryonic stem cells whole embryo culture suggested would relevant studying developmental effects terms substances categorization elsevier ltd rights reserved
fluid mechanics solve multiple solutions ordinary differential equations always concerned difficult problem improved rna genetic algorithm inspired rna molecular structure operators proposed solving parameter estimation problems multiple solutions described flow fluid porous channel expanding contracting walls paper multiple solutions found changing accuracy search coverage multi iterations computer last ordinary differential equations calculated result great accuracy method practical authors published elsevier ltd
aim study explore association serum uric acid sua metabolic syndrome mets premenopausal postmenopausal women jinchang cohort studied female jinchuan nonferrous metals corporation workers aged years cohort data epidemiological surveys medical exams used mets defined using joint interim society criteria relationship sua mets evaluated using multiple logistic regression adjusting potential confounders mets hyperuricemia prevalent postmenopausal women premenopausal ones versus versus respectively premenopausal postmenopausal women hyperuricemia respectively times odds mets counterparts without hyperuricemia even within normal sua quartiles premenopausal women highest second highest quartile respectively times odds mets lowest quartile even normal range odds ratios mets increased gradually according sua levels women trend conclusion significant correlation sua levels mets association stronger premenopausal women postmenopausal ones
reported higher risk maternal fetal complications women myeloproliferative neoplasms mpn poses challenge pregnancy national prospective study maternal fetal outcomes pregnant women diagnosis mpn undertaken via united kingdom obstetric surveillance system january december fifty eight women diagnosis mpn identified essential thrombocythaemia five polycythaemia vera five myelofibrosis one mpn unclassified live births incidence miscarriage confidence interval perinatal mortality rate live stillbirths incidence maternal complications pre eclampsia post partum haemorrhage post partum haematoma maternal deaths thrombotic events delivery induced women caesarean section rate majority delivered term weeks gestation twenty two percent neonates centile growth required admission neonatal care unit neonatal deaths findings large prospective study suggests women mpn appear successful pregnancies better outcomes would anticipated literature
many low mid power applications critical mode boost power factor corrector converters widely used low switching loss simple control however near zero crossing input line voltage input current distortion low power factor caused delayed switching period negative input currents generally additional time method according input voltage used compensate input current distortion however detailed quantitative analysis exact additional time studied till paper explicit form optimized additional time obtained using quantitative analysis advantage digital control state trajectory net input charge analysis shown optimized time related input voltage also output power also order improve efficiency high input light load condition circulating currents reduced inevitable dead angle gate turning technique using digital control optimized additional time gate turn technique implemented rms input output prototype
geographers technology illustrate software code contexts effects agencies shape urban space everyday life consequences code nature remain understudied political ecologists critiqued remote sensing geographic information systems gis based conservation projects engaged broadly role software contested production circulation application ecological knowledge yet around world data analytics firms conservation nonprofits argue optimizing environmental management faster bigger data collection new techniques data manipulation visualization present case study state oregon illustrating conservationists environmental regulators employ computer programming plan markets entrepreneurs restore stream wetland ecosystem services earn offset credits markets code executed algorithms constituting spreadsheets web maps gis utilities generate relate make sense data define credit commodities argue code tends toward three effects producing landscape defined wetlands modeled value performing social relations associated nature neoliberalization financialization legitimating moves although emphasis performativity code technological objects warranted contexts authored deployed evaluated remain central understanding environmental governance caution seeing technology reducing nature society state capitalist rationalities hesitate differentiate prima facie code work space nature call bridging political ecology geographies technology ways explain code generative environmental knowledge change conflict
work aimed study response growing rabbit caecal ecosystem bacterial community caecal environmental parameters switch control low fibre diet lfd group rabbits fed libitum control diet adf weaning days days age day rabbits switched lfd group adf whereas others control group remained control diet days caecal contents regularly sampled throughout trial rabbits per group bacterial community structure characterized using sscp capillary electrophoresis single strand conformation polymorphism total bacteria quantified using real time pcr redox potential volatile fatty acid vfa measured caecum characterize environmental parameters reduction fibre diet modified sscp profiles diversity index number rrna gene copies total bacteria decreased lfd rabbits compared controls lfd rabbits caecal environment less acid units reductive drier per increase decrease total vfa concentration found significant correlations bacterial community quantity bacteria caecal traits caecal ecosystem indeed groups caecal traits barely constrained total inertia sscp profile set less whereas total bacteria positively related total vfa acetic acid butyric acid levels negatively related microbial environmental modifications occurred day remained stable thereafter results suggest bacterial community growing rabbit caecum able adapt quickly change dietary fibre supply reach new steady state equilibrium
model operational amplifier based vhdl ams proposed according needs simulating total ionizing dose ted radiation effect parameters operational amplifier taken account performance specified operational amplifier model used tid radiation effect simulation completed verifying modeled parameter parameter describing external environment introduced make model combined tid finally example used illustrate tid effect operational amplifier proving validity model
backgroundmany transgender college students struggle identity formation emotional social developmental challenges associated emerging adulthood potential maladaptive coping strategy employed students heavy drinking prior literature suggested greater consumption negative alcohol related consequences arcs transgender students compared cisgender peers little known differing experiences alcohol related blackouts arbs examined level alcohol consumption frequency arbs arcs motivations drinking reported largest sample transgender college students date methodsa web survey alcohol prevention program alcoholedu college assessed student demographics drinking related behaviors experiences motivations newly matriculating first year college students self reported drinking calendar used examine following measures previous days number drinking days total number drinks maximum number drinks single day point likert scale used measure arcs arbs drinking motivations transgender students sexes compared cisgender peers resultsa total students identified transgender day period transgender compared cisgender students likely consume alcohol days total drinks greater number maximum drinks single day transgender students likely report arb cisgender students well negative academic confrontation related social sexual arcs transgender respondents often cited stress reduction social anxiety self esteem issues inherent properties alcohol motivations drinking nearly measures higher values yielded male female female male transgender students conclusionstransgender compared cisgender first year students engage higher risk drinking patterns experience arbs negative arcs broad institutional efforts required address unique circumstances transgender men women reduce negative arcs college students regardless sex gender identity
wildfire size frequency expected increase many forested areas united states organizations involved forest wildfire management could arguably benefit working together sharing information develop strategies adapt increasing risk social capital theory suggests actors cohesive networks positioned build trust mutual understanding problems act collectively address problems actors engaged diverse partners positioned access new information resources important innovation complex problem solving investigated patterns interaction within network organizations involved forest wildfire management oregon usa evidence structural conditions create opportunities collective action learning used descriptive statistical analysis social network data gathered interviews characterize structure network exponential random graph modeling identify key factors formation network ties interpreted findings lens social capital theory identify implications network capacity engage collective action complex problem solving adapt environmental change found tendencies associate others similar management goals geographic emphases attitudes toward wildfire strong mechanisms shaping network structure potentially constraining interactions among organizations diverse information resources limiting opportunities learning complex problem solving needed adaptation particular found organizations fire protection forest restoration goals comprised distinct networks despite sharing concern problem increasing wildfire risk
show lindblad operators generators quantum markov semigroups finite dimensional hilbert space satisfying detailed balance condition respect thermal equilibrium state written gradient system respect relative entropy discuss also thermodynamically consistent couplings macroscopic systems either damped hamiltonian systems constant temperature generic systems
present methodology based matrix factorization gradient descent predict number sessions established access points network according users behavior network considered work monitored controlled software order manage users resources real time may consider cyber physical system interacts physical world access points whose demands predicted according users activity predictions useful relocating reinforcing access points according changing physical environment work propose prediction model based machine learning techniques validated comparing prediction results real user activity experiments collected activity users demanding network sessions one month network composed access points results qualitatively valid regard previous knowledge conclude proposal suitable predicting demand sessions access points devices removed taking account usual activity network users elsevier rights reserved
demonstrated entanglement evolution specially designed quantum state bistochastic channel asymmetric work generalize study quantum correlations including entanglement quantum discord evolution asymmetry various quantum channels found asymmetry entanglement quantum discord occurs special quantum channels behavior entanglement evolution may quite different behavior quantum discord evolution quantum entanglement channels decreases monotonously increase quantum channel intensity channels increase intensity quantum channel decreases first keeps zero time rises quantum discord evolution becomes complex may find evolutes unsmoothly points results illustrate strong dependence quantum correlations evolution property quantum channels
purpose study investigate prevalence hypothyroidism among hospitalized patients type diabetes mellitus related factors assess prevalence macrovascular microvascular diseases among type diabetes mellitus inpatients hypothyroidism euthyroidism total type diabetes mellitus inpatients hospitalized metabolic diseases hospital tianjin medical university january march included study information demographic anthropometric factors additional variables related hypothyroidism collected medical records prevalence rates calculated standardized using direct method based age specific sex specific structure participants data analyzed using binary logistic regression adjustment potential confounders prevalence hypothyroidism among type diabetes mellitus inpatients patients hypothyroidism subclinical hypothyroidism prevalence hypothyroidism increased age higher women men older age odds ratio confidence interval female gender odds ratio confidence interval positive thyroid peroxidase antibody odds ratio confidence interval associated higher odds hypothyroidism among type diabetes mellitus inpatients type diabetes mellitus inpatients hypothyroidism higher prevalence cerebrovascular diseases euthyroidism adjustment age gender prevalence hypothyroidism among type diabetes mellitus inpatients patients subclinical hypothyroidism older age female gender positive thyroid peroxidase antibody could indicators detecting hypothyroidism type diabetes mellitus inpatients
fasting hypertriglyceridemia positively associated morbidity coronary heart disease chd postprandial non fasting hypertriglyceridemia also correlated risk status chd related increase chylomicron remnant lipoproteins produced intestine remnant particles well oxidized low density lipoprotein ldl low density lipoprotein vldl remnants highly atherogenic act enhancing systemic inflammation platelet activation coagulation thrombus formation macrophage foam cell formation cholesterol levels remnant lipoproteins significantly correlate small dense ldl impaired glucose tolerance igt chd prevalence developed assay apolipoprotein apo levels evaluate accumulation remnants fasting apob levels correlate morbidity postprandial hypertriglyceridemia obesity type hyperlipoproteinemia metabolic syndrome hypothyroidism chronic kidney disease igt fasting apob levels also correlate carotid intima media thickening chd prevalence high apob level significant predictor chd risk independent fasting level diet interventions dietary fibers polyphenols medium chain fatty acids diacylglycerol long chain polyunsaturated fatty acids pufa ameliorate postprandial hypertriglyceridemia moreover drugs dyslipidemia pufa statins fibrates ezetimibe diabetes concerning incretins dipeptidyl peptidase inhibitor glucagon like peptide analogue may improve postprandial hypertriglyceridemia since accumulation remnants correlates impaired lipid glucose metabolism atherosclerotic cardiovascular events studies required investigate characteristics physiological activities functions remnants development new interventions reduce atherogenicity
two test sections along newly constructed road embankment peat foundations instrumented investigate performance develop economical means construction method peat deposit study area average thickness one test section embankment geotextile base geotextile timber logs corduroy settlements measured using monitoring plates pins ground temperatures measured using thermistor strings pore water pressures measured using vibrating wire piezometers paper presents monitoring results two fully instrumented sections results show adding timber logs near toe slope reduced settlement peat foundation therefore reducing requirement fill material maintain road elevation
smart environments spaces interact users taking account needs preferences systems manage environments need manipulate context interacting suitable way users one big challenge creating smart environment deal context dynamicity ideally computer supported environments must detect relevant events forecast future situations act proactively mitigate eliminate situations related specific user needs paper proposes framework providing extensible reactive proactive behavior smart environment systems focus present work related specific class smart environments ambient assisted living sense define framework illustrate practical aspects use framework describing home care scenario system observes behavior user time goes detects relevant situations acts reactively proactively preserving user health condition
rapid growth unstructured data last years led emergence new database management systems traditional relational databases despite wide adoption plethora features begin show weaknesses deal large amounts data numerous types databases emerged cloud domain order exploit elasticity cloud environments relaxing typical acid considerations investigating trade offs cap theorem aim paper investigate offerings mongodb cassandra hbase namely based tradeoffs behave deployed virtual environments bonfire facility measured widely used benchmarks ycsb results may helpful potential adopters choose offerings based individual needs specific workloads query structures
paper presents results investigation performance efficiencies silt fence fabrics turbidity sediment concentration removal determination flow rate simulated construction sites real time two silt fence fabrics woven type nonwoven type subjected material index property tests series field scale tests fabrics tested removal efficiency varying rainfall intensities events different embankment slopes tilting test bed collected influent effluent samples analyzed sediment concentration turbidity flow rate fabric evaluated test results revealed woven nonwoven silt fence achieved percent average turbidity reduction efficiency percent average sediment concentration removal efficiency respectively evaluation sediment concentration reduction based percent removal correctly account sediment concentration transported deposited downstream fabric flowrates functions rainfall intensity embankment slope field conditions fluctuates every rainfall event elsevier ltd rights reserved
matrix metalloproteinase mmp disintegrin metalloproteinase thrombospondin motifs adamts thought play critical roles cartilage degradation early phase osteoarthritis aim study examine effect chemically modified mmp adamts small interfering rna sirna alone combination mouse model pathology surgically induced week old male mice via destabilization medial meniscus dmm used chemically modified sirna accell sirnasa mmp adamts well non targeting control evaluated combined individual effects injection dmm model control group injected non targeting sirna normal group undergo surgical induction intra articular injection histological assessment articular cartilage conducted weeks post dmm surgery evaluate progression significant improvement histological score observed weeks dmm three sirna treated groups compared control sirna injected group score combined group significantly lower adamts sirna group significant differences noted mmp sirna group combined group combined intra articular injection mmp adamts sirna resulted almost inhibitory effects mmp sirna alone cartilage degradation early phase
derived rapidly computed analytical solution drawdown caused partially fully penetrating directional wellbore vertical horizontal slant via green function method mathematical model assumes anisotropic homogeneous confined box shaped aquifer dimension box one six possible boundary conditions sides flux one side flux one side constant head sides constant head one side flux one side constant head free boundary conditions solution optimized rapid computation via poisson resummation derivation convergence rates numerical optimization integration techniques upon application poisson resummation method able derive two sets solutions inverse convergence rates namely early time rapidly convergent series solution late time rapidly convergent series solution work able link green function method solution back image well theory solution derived equation defining convergence rate solution solution termed switch time utilizing rapidly convergent solution appropriate time obtained rapid convergence times also shown one may simplify three infinite series three dimensional solution terms still maintain maximum relative error less elsevier ltd rights reserved
aid symbolic computation maple discrete ablowitz ladik equation studied via algebra method new rational solutions four arbitrary parameters constructed analyzing related parameters discrete rogue wave solutions alterable positions amplitude focusing ablowitz ladik equations derived properties discussed graphical analysis might helpful understanding physical phenomena optics
investigation paper discrete dimensional ablowitz ladik equation certain applications nonlinear optics bose einstein condensation employing hirota method symbolic computation obtain bright dark one two three soliton solutions asymptotic analysis indicates interactions bright dark two solitons elastic amplitudes velocities bright dark solitons increase value coupling strength increasing head overtaking interactions bright two solitons well bound state two solitons depicted overtaking interaction dark two solitons also plotted increasing value coupling strength lead increasing amplitudes velocities bright dark two solitons published elsevier
background nitric oxide metabolites nitrate nitrite important regulators linked various diseases studied association fasting serum concentrations nitrate nitrite combined nox without special diet prevalence various chronic diseases methods fasting concentrations nox assayed cohort patients recruited stress aging health russia study represents male female population moscow russia years age chronic diseases recorded based anamnesis additional assays run characterize immune status lipid carbohydrate metabolism odds ratios calculated associate nox concentrations prevalence chronic diseases pooled deciles borderline results nox associated increased prevalence various chronic diseases diabetes type hyperthyroidism coronary heart disease gout thrombosis stroke nox associated lowered prevalence osteoporosis nox levels associated significantly higher number patients abstain consumption alcoholic beverages nox associated cancer conclusions thus fasting concentrations nox serum important diagnostic parameter characteristic specific chronic diseases
relationship autism spectrum quotient schizotypal personality questionnaire spq data consistently shown overlap social interpersonal domains factor analyses spq subscales support overlap emergence shared spq subscale factor largest common element study investigated item level factor structure spq exploratory confirmatory factor analyses conducted spq responses participants aged females males seven factors cumulatively explained data four represented shared traits named odd behaviour relationship disinterest cue interpretation social communication discomfort one specific autistic tendency named fixation details two factors specific psychotic dimension schizotypy named paranoia suspiciousness hallucination delusional experiences findings demonstrate set symptom traits present autism schizophrenia spectra findings study important clinical implications terms future research diagnosis treatment autism schizophrenia spectrum disorders elsevier ltd rights reserved
combustion chamber liquid propellant launch vehicle inner shell chamber copper alloy cooling channels regenerative cooling outer shell steel maintain high pressure inside chamber purpose study find optimum condition diffusion bonding copper steel experimental conditions different pressures temperatures degrees degrees order characterize flow strength materials high temperatures several tensile tests performed several temperatures degrees degrees information used estimate test condition diffusion bonding superplastic forming mechanical properties bonded specimen evaluated single lap joint tests shear tests microstructure bonded layer also observed sem edx shown optimum condition diffusion bonding mpa degrees one hour pressurization test bonded specimen cooling channels performed hydraulic pressure mpa without failure
two proteins bovine serum albumin egg white lysozyme used model adsorbents food industry dairy wastewater multi walled carbon nanotubes mwcnt amine functionalized multi walled carbon nanotubes mwcnt surfaces used adsorbents various effective parameters contact time initial concentration proteins initial levels temperature well investigated optimized using batch adsorption study upon optimization observed increasing initial concentration adsorption proteins also increases equilibrium adsorption data lysozyme using mwcnts mwcnt adsorbents well fitted good agreement type langmuir isotherm model freundlich isotherm model respectively hand serum albumin adsorption using mwcnts mwcnt adsorbents described well fitted good agreement type langmuir isotherm model elsevier rights reserved
low testosterone levels associated metabolic cardiovascular disease risk factor shown predict type diabetes mellitus tdm myocardial infarction cause mortality known associations causal recently shown serum testosterone levels associated single nucleotide polymorphisms snps therefore studied associations one snps sex hormone binding globulin shbg gene tdm cancer death dna prepared men participated fourth survey tromso study registered endpoints tdm cancer death randomly selected control group mortality observation time set endpoints birth endpoint data completed genetic analyses successfully performed men registered tdm cancer died men minor homozygote genotype significantly higher levels total testosterone shbg compared men major homozygote genotype whereas free testosterone levels differ significantly genotypes snp significantly associated tdm cancer mortality thus result support causal relationship total testosterone shbg tdm cancer mortality suggesting low testosterone likely marker poor health
background reduction cost genomic assays generated large amounts biomedical related data result current studies perform multiple experiments subjects bioconductor methods classes implemented different packages manage individual experiments standard class properly manage different omic datasets subjects addition bioconductor packages designed integrate visualize biological data often use basic data structures clear general methods subsetting selecting samples results cover need developed multidataset new class based bioconductor standards designed encapsulate multiple data sets multidataset deals usual difficulties managing multiple non complete data sets offering simple general way subsetting features selecting samples illustrate use multidataset three common situations performing integration analysis third party packages creating new methods functions omic data integration encapsulating new unimplemented data biological experiment conclusions multidataset suitable class data integration bioconductor framework
triclinic phase zinc molybdate alpha znmoo zmo synthesized simple precipitation method degrees crystal structure obtained polycrystalline sample zmo characterized ray diffraction xrd rietveld calculations using space group electrical properties alpha znmoo compacted pellets determined room temperature electrical impedance spectrometry eis temperature range degrees nyquist representations interpreted terms two types electrical circuits involving high frequency bulk component low frequency warburg component analyses frequency dependence real imaginary impedance show non debye type relaxation phase transition corresponding allotropic transformation triclinic monoclinic alpha beta znmoo observed temperature range degrees variation activation energies warburg component discussed terms electrode surface reactions elsevier ltd techna group rights reserved
aim confirm previous conclusions saccharomyces cerevisiae cerevisiae cncm irritable bowel syndrome ibs management methods individual patient data meta analysis per formed two randomized clinical trials studying effect cerevisiae cncm supplementation gastrointestinal symptoms ibs subjects total ibs subjects included outcomes daily likert scale scores abdominal pain discomfort bloating area curve auc weekly means responder status bowel movements stool frequency consistency statistical analyses conducted intent treat itt population ibs subjects ibs subjects abdominal pain discomfort score higher equal baseline ibs subpopulation results cerevisiae cncm significantly improved abdominal pain discomfort bloating second month supplementation auc improvement minimal clinically relevant threshold reduction abdominal pain discomfort itt population compared placebo group observed ibs subpopulation reduction abdominal pain discomfort reduction bloating compared placebo group respectively symptoms significantly decreased supplementation statistical differences reported groups end supplementation period responder status defined subject experienced decrease arbitrary unit abdominal discomfort score baseline least last study significant difference groups reported itt population considering first definition subjects active group higher odds responder reduction abdominal pain discomfort compared subjects placebo group end supplementation period stool consistency active group itt population significantly improved classified normal compared placebo respectively similar results seen ibs subpopulation active group placebo group conclusion meta analysis supports previous data linking cerevisiae improvement symptoms ibs overall population ibs ibs subpopulations
nowadays companies putting emphasis making supply chains leaner leaner supply chain perspective carriers shippers always looking increase profitability container tracking assists reducing costs saves time regarding customer service improvement hand every consignee needs informed last position situation cargo paper different methods cargo tracking shipping companies based satellite radio frequency identifier rfid global system mobile communications gsm discussed eventually end end integrated intelligent tracking method introduced regarding customers requests needs availability cost different methods customer requirements proposed model key parameters according model expedite efficient end end container cargos first stage release shipper last stage return consignee destination considered
covering problems well studied operations research literature assumption set users set potential facilities finite paper address following variant leads mixed integer nonlinear program minlp locations facilities sought along edges network expected demand covered maximized demand continuously distributed along edges minlp combinatorial part edges network chosen contain facilities continuous global optimization part edges chosen optimal locations within edges branch bound algorithm proposed exploits structure problem specialized data structures introduced successfully cope combinatorial part inserted geometric branch bound algorithm computational results presented showing appropriateness procedure solve covering problems small non trivial values elsevier ltd rights reserved
paper introduces simultaneous state topology estimation method able process conventional scada synchrophasor measurements devised extract analog measurements estimates state variables also information concerning underlying network topology accomplished representing selected parts electrical network bus section level using specialized multiobjective optimization framework formulate joint estimation problem multiobjective criterion comprises familiar weighted least squares term additional least absolute value component models switching branch statuses proposed approach seen validation step outcome produced network processors thereby preventing occurrence topology errors results presented paper show joint estimation approach extended allow phasor measurement processing capability whole scheme draw significant benefits extension
highly reconfigurable merged analog baseband mabb tunable bandwidth gain order also reconfigurable power noise linearity proposed multistandard integrated wireless receivers brief mabb could arrange total gain different stages noise linearity tradeoffs introducing merged biquad topology save power operational amplifier opamp proposed mabb reduce gbw long meets gbw requirement different gain order flexible power efficient high gbw opamp adaptive common mode bias circuit also proposed eighth order active mabb proposed mabb covers cutoff frequency range khz mhz whereas gain could tuned proposed highly reconfigurable mabb suitable multistandard integrated wireless receivers
modern days breakthroughs information communications technologies lead devices every imaginable type connected internet also strengthens need protection cyber attacks virtually devices wireless connection could vulnerable malicious hacking attempts meanwhile honeypot based deception mechanism considered one methods ensure security modern networks internet things iot paper address problem defending attacks honeypot enabled networks looking game theoretic model deception involving attacker defender attacker may try deceive defender employing different types attacks ranging suspicious seemingly normal activity defender turn make use honeypots tool deception trap attackers problem modeled bayesian game incomplete information equilibria identified one shot game repeated game versions results show threshold frequency active attackers players take deceptive actions defender mix strategy keeping attacker success rate low
evaluated incidence catheter related bladder discomfort crbd efficacy solifenacin preventing crbd transurethral resection bladder tumor tur patients non muscle invasive bladder cancer incidence rate crbd hours tur respectively solifenacin failed decrease incidence severity crbd background catheter related bladder discomfort crbd secondary indwelling urinary catheter worse transurethral resection bladder tumor tur evaluated incidence crbd efficacy solifenacin preventing crbd tur patients non muscle invasive bladder cancer patients methods present prospective randomized multicenter trial enrolled patients non muscle invasive bladder cancer underwent elective tur general anesthesia patients randomized group group primary outcome evaluable patients included final analysis group received solifenacin orally day day day tur control group group received standard care crbd assessed hours postoperatively pain assessed days starting hours tur using visual analog scale results incidence rates crbd groups hour hours respectively incidence rates severity crbd hours different groups visual analog scale scores postoperative consumption analgesics different groups none patients received solifenacin experienced adverse event conclusion pretreatment solifenacin failed decrease incidence severity crbd tur
integrating computer vision natural language processing novel interdisciplinary field received lot attention recently survey provide comprehensive introduction integration computer vision natural language processing multimedia robotics applications key references tasks survey include visual attributes image captioning video captioning visual question answering visual retrieval human robot interaction robotic actions robot navigation also emphasize strategies integrate computer vision natural language processing models unified theme distributional semantics make analog distributional semantics computer vision natural language processing image embedding word embedding respectively also present unified view field propose possible future directions
paper introduces optimization formulation design residential water systems satisfy water demands housing complex involving rainwater harvesting storage distribution well simultaneous design water networks recycling reusing regenerating storing reclaimed water design task considered multi objective optimization problem one objective minimization fresh water consumption objective minimization total annual cost proposed model accounts variability water demands different hours day different seasons year seasonal dependence rainwater also considered optimization model case study city morelia mexico presented results show significant reductions obtained total fresh water consumption total cost elsevier ltd rights reserved
confabulations offer unique opportunities establishing neurobiological basis delusional thinking regards causal factors review confabulation literature suggests neither amnesia executive impairment sole perhaps even primary cause delusional beliefs though may act concert factors key perspective modern literature many delusions emotionally positive wishful element may serve modulate manage emotional experience authors referred perspective emotion dysregulation hypothesis article review theoretical underpinnings approach develop idea suggesting positive aspects confabulatory states may role perpetuating imbalance cognitive control emotion draw existing evidence fields outside neuropsychology argue three main causal factors positive emotions related global schematic forms cognitive processing positive emotions influence accuracy memory recollection positive emotions make people susceptible false memories findings suggest emotions want feel want feel influence way reconstruct past experiences generate sense self proposition bears unified theory delusional belief states crown copyright published elsevier ltd rights reserved
gut microbiome emerging important factor regulating mental health yet remains unclear target psychiatric treatment aimed elucidate complement gutmicrobiome community individuals bipolar disorder relative controls test relationships burden disease measures compared stool microbiome individuals bipolar disorder control subjects using ribosomal rna rrna gene sequence analysis analysis molecular variance amova revealed global community case control differences amova operational taxonomical unit otu level analysis revealed significantly decreased fractional representation faecalibacterium adjustment age sex bmi false discovery rate fdr correction level within individuals bipolar disorder fractional representation faecalibacterium associated better self reported health outcomes based short form health survey patient health questionnaire phq pittsburg sleep quality index psqi generalized anxiety disorder scale gad altman mania rating scale asrm independent covariates study provides first detailed analysis gut microbiome relationships multiple psychiatric domains bipolar population data support hypothesis targeting microbiome may effective treatment paradigm bipolar disorder elsevier ltd rights reserved
paper presents novel system allows elevating large structures using set lifting towers adequately controlled synchronized operation succeed pulling spatial mesh height stay mounting spatial mesh carried ground easier important safer way also gives rise shorter final time thereby cost reduction paper deals elevation system designed pull mesh specifically focuses electronic system allows controlling movement comments overall control coordinates operation mechanical structures involved also provided
urinary incontinence overactive bladder oab health conditions higher prevalence rates later life lead profound negative effect related quality life evidence lacking effects conservative multimodal physical therapy interventions oab older population case study presents multimodal intervention year old woman oab sessions patient demonstrated improved related quality life significantly decreased urinary symptoms urinary distress index short form udi scores improved pelvic floor muscle performance improved increased strength endurance coordination case supports use multimodal interventions older patients oab
microgrids comprise variety distributed energy resources energy storage devices loads majority sources suitable direct connection electrical network due characteristics energy produced low voltage power fuel cells arrays high frequency power microturbines therefore voltage source converters vscs required interface network microgrids distribution network voltage reference setting vscs operating voltage regulator mode optimal power reference settings remaining vscs working power dispatcher mode must pre determined maintain voltage within desired margins paper problem formulated optimization problem vscs switching conduction losses selected objective function computational intelligence techniques including genetic algorithm simulated annealing based optimization methods employed solve optimization problem results optimal power flow compared conventional power flow
children autism spectrum disorders asds usually diagnose disturbances following domains social relatedness communication play restricted interests activities result interacting communicating children asds intricate lack verbal nonverbal communication skills understanding needs children also challenging task difficulty expressing needs verbally using gestures pointing instead words facilitate social interaction special effort needs made parents caregivers hence educational app children asds developed assist application helps children asds improve social life interacting communicating others helping parents caregivers understand children really needs time application easily customized adding activities needs arise authors published elsevier
functionalized polypropylene nonwoven geotextiles used new eco friendly way trap heavy metals sediments chitosan chosen sorbent ability trap heavy metals natural origin shells low cost first functionalized acrylic acid using low pressure cold plasma process order bring reactive carboxylic functions onto surface chitosan covalently grafted acrylic acid modified functionalized surfaces characterized fourier transform infrared spectroscopy attenuated total reflectance ftir atr ray photoelectron spectroscopy xps evidence chitosan grafting given ability functionalized geotextile trap heavy metals investigated copper chosen model heavy metal artificial solutions cuso prepared experiments sorption studies carried degrees polypropylene grafted acrylic acid chitosan chitosan varying concentration copper polluted solutions evaluate maximum adsorption surface textile chelate copper increasingly function initial copper concentration ppm concentration reaches plateau trapped copper per gram geotextile effects ionic strength adsorption nacl containing solution finally investigated trapping decreases slowly ionic strength increases nacl artificial polluted solution like seawater trapped per geotextile finally optimum trap maximum amount copper determined corresponds optimum chitosan solubility elsevier ltd rights reserved
background radiofrequency ablation rfa relatively new procedure treating benign thyroid nodules purpose study evaluate safety efficacy rfa treating benign thyroid nodules serve reference future clinical practice methods study retrospectively analyzed clinical data patients receiving percutaneous rfa treating thyroid nodules november july medical center one hundred eight patients total nodules received ultrasound guided rfa treating thyroid nodules comparisons volume change thyroid nodules rfa treatment post treatment complication change thyroid function carried afterwards results treatments patients received fine needle aspiration biopsy fna supported diagnosis benign tumor males females included study twenty six cases single nodule cases multiple nodules treatments thyroid functions tsh normal originally adjusted normal range endocrinology treatment preoperative nodules minimum volume maximum volume mean volume volume nodules one month three months rfa respectively addition volume reduction ratio vrr nodules one month three months rfa respectively volume nodules vrr statistically significant differences pre operative post operative comparison thyroid functions normal range treatments serious complications conclusions ultrasound guided rfa treating benign thyroid nodules advantages definite efficacy safety strong control ability incision less damage surrounding normal tissues effect thyroid function used one main treatment methods treating benign thyroid nodules
objectives estimate rates hospitalizations patients within months first rituximab administration methods patients received rituximab either benign malignant conditions identified texas medicare files hospitalization rates patients diagnoses might represent toxicity compared months first infusion rituximab dose response analyses performed basis number doses received weeks initiating rituximab also using cumulative number doses time dependent covariate results patients received rituximab single agent malignant indications received benign indications overall inpatient admission rates differ significantly months rituximab initiation patients benign malignant conditions malignant conditions higher rates hospitalizations cardiovascular infectious pulmonary neurological diagnoses rituximab initiation nonmalignant conditions increase hospitalizations infections neither group patients showed clear dose response relationships toxicity conclusions increased hospitalizations potential toxicities seen patients malignant disease presumably underlying disease process rituximab rituximab appear associated hospitalizations serious toxicity within months first infusion possible exception infection
background disease management programs dmps introduced within german healthcare system aim increase quality chronic disease care due enrollment procedures assumed certain patients actively decide enroll dmp certain patients get recommendation dmp enrollment physician strong assumed effect self professional selection still unclear methods used data cross sectional postal survey linked individual level administrative claims data german sickness fund sample consisted individuals suffering coronary heart disease chd either enrolled respective dmp fulfilled disease related criteria enrollment enrolled applied multivariate logistic regression analyses assess factors patient level associated dmp enrollment results included individuals analyses male sex higher age receiving old age pension higher charlson score diagnosis type diabetes increased odds dmp chd enrollment significantly individuals diagnosed myocardial infarction also likely enrolled dmp chd found significant interaction effect sex indicating association dmp enrollment stronger women men conclusion dmp enrollees non enrollees differ various factors studies analyzing effectiveness dmp chd carefully take account group differences furthermore results suggest dmp chd assessed reaches men better women
european spallation source ess currently construction lund sweden world powerful source neutrons goal deliver neutrons users reach full power sometime middle following decade one key issues ess develop strategy along proper innovative tools efficiently communicate smoothly collaborate divisions groups inside ess outside collaborators called kind contributors ikc technical requirements related scope delivered among important technical information exchanged information exchange facilitated using commercial requirements management database accessible web physics multidisciplinary needs linked engineering integration linaclego tool provides updated lattice data accelerator lattice information gathered utilized control physical positioning mechanical engineering components accelerator precision operation provided dedicated mechanical design skeleton computer aided design cad environment finally realization steps supervised detail continuously evaluated way required ess machine design delivered terms engineering physics aspects
background basophils important effector cells involved pathogenesis inflammatory skin diseases including chronic urticaria associated increased serum levels far effects human basophils unknown objective analyse functional role basophil biology methods expression evaluated skin samples derived chronic spontaneous urticaria patients oncostatin receptor osmr receptor protein expressions analysed human basophils healthy donors basophil responses assessed chemotaxis externalization cdc well release histamine results osmr expressed human basophils strongly expressed skin patients chronic spontaneous urticaria released isolated basophils following either anti ige fmlp stimulation induced chemotaxis release specifically inhibited anti anti osmr conversely effect cdc externalization histamine release conclusions clinical relevance human basophils source activated release pro inflammatory cytokines induction chemotaxis indicating important novel function basophil biology
despite widespread clinical use cryoablation remain questions regarding dosing treatment times may affect efficacy collateral injury dosing treatment times directly related degree cooling necessary effective lesion formation human swine atrial ventricular lung tissues ablated using two cryoablation systems concurrent infrared thermography post freeze thaw samples cultured stained differentiate viable non viable tissue matlab code correlated viability staining applied freeze thaw thermal cycles determine injury thresholds tissue regions classified live injured dead based upon staining intensity lesion margin injury begins rates degrees min degrees non viable tissue requiring cooling rates close degrees min degrees swine significantly greater cooling degrees human tissue similar rates lung tissue injury began degrees human tissue requiring significantly less cooling degrees complete necrosis degrees swine data suggest significant differences swine human myocardial response may differences swine human lung cryothermal tolerance elsevier inc rights reserved
security quantum key distribution qkd relies heisenberg uncertainty principle legitimate users able estimate information leakage monitoring disturbance transmitted quantum signals normally disturbance reflected bit flip errors sifted key thus privacy amplification removes leaked information key generally depends bit error rate recently round robin differential phase shiftqkdprotocol privacy amplification rely bit error rate sasaki nature proposed amount leaked information bounded sender state preparation stage hence independent behavior unreliable quantum channel work apply tagging technique protocol present tight bound key rate employ decoy state method effects background noise misalignment taken account practical conditions simulation results show protocol tolerate channel error rates close within typical experiment setting negligible restriction error rate practice
background anti tnf agents revolutionised rheumatoid arthritis treatment however third patients fail achieve therapeutic responses unexpectedly studies murine human arthritis indicated anti tnf treatment increase circulating helper cells relationship treatment response unclear identify immune correlates anti tnf treatment response conducted longitudinal study using clinical ultrasound cell assessments methods patients studied protocol visits initial weeks anti tnf treatment improvement disease activity score joints das defined treatment responders non responders changes synovial thickening vascularity metacarpophalangeal joints quantitatively assessed grey scale power doppler ultrasound frequency circulating cells determined enzyme linked immunospot assay elispot flow cytometry fluorescence activated cell sorting facs results frequency circulating producing cells increased significantly weeks anti tnf initiation elispot median range specific spot forming cells spsfc increase cells weeks confirmed facs median range increase circulating cells inversely correlated reduction synovial vascularity thickening higher frequencies circulating cells baseline associated poorer anti tnf treatment response defined ultrasonographic measures conclusions results demonstrate link changes circulating cells resolution ultrasonographic features synovial inflammation vascularity anti tnf treatment findings may reflect redistribution cells inflamed joints tnf driven regulation cell production
background traditional sanger sequencing used gold standard method genetic testing clinic perform single gene test cumbersome expensive method test several genes heterogeneous disease cancer advent next generation sequencing technologies produce data unprecedented speed cost effective manner overcome limitation sanger sequencing therefore efficient affordable genetic testing next generation sequencing used complementary method sanger sequencing disease causing mutation identification confirmation clinical research however order identify potential disease causing mutations great sensitivity specificity essential ensure high quality sequencing data therefore integrated software tools lacking analyze sanger ngs data together eliminate platform specific sequencing errors low quality reads support analysis several sample patients data set single run results developed clinqc flexible user friendly pipeline format conversion quality control trimming filtering raw sequencing data generated sanger sequencing three ngs sequencing platforms including illumina ion torrent first clinqc convert input read files native formats common fastq format remove adapters pcr primers next split bar coded samples filter duplicates contamination low quality sequences generates report clinqc output high quality reads fastq format sanger quality encoding directly used stream analysis analyze hundreds sample patients data single run generate unified output files sanger ngs sequencing data tool expected useful quality control format conversion sanger ngs data facilitate improved downstream analysis mutation screening conclusions clinqc powerful easy handle pipeline quality control trimming clinical research clinqc written python multiprocessing capability run major operating systems available https sourceforge net projects clinqc
background medical education highly stressful higher stress documented medical students stepping entirely new environment huge medical course syllabus mastered short period time continuous internal assessments examinations far family social personal issues prone develop negative emotional symptoms newly joined student objective determine prevalence depression anxiety stress among year medical students aims nagar methods cross sectional questionnaire based study conducted among year medical students aims nagar results among students students completed questionnaire response rate female students male students within age group years study students showed depression students showed anxiety students showed stress different grades mild moderate severe severe incidence depression almost similar gender incidence anxiety stress among females conclusion study prevalence anxiety stress medical students females anxious stressful males early interventions timely monitoring done address negative emotional symptoms counselling students workshops stress management daily physical activities could help come health issues
melatonin methoxyindole synthesized secreted principally pineal gland night normal light dark conditions endogenous rhythm secretion generated suprachiasmatic nuclei entrained light dark cycle light able either suppress synchronize melatonin production according light schedule nycthohemeral rhythm hormone evaluated repeated measurement plasma saliva melatonin urine sulfatoxymelatonin main hepatic metabolite primary physiological function melatonin whose secretion adjusts night length convey information concerning daily cycle light darkness body structures information used organisation functions respond changes photoperiod seasonal rhythms seasonal rhythmicity physiological functions humans related possible alteration melatonin message remains however limited evidence temperate areas field conditions also daily melatonin secretion robust biochemical signal night used organisation circadian rhythms although functions hormone humans mainly based correlations clinical observations melatonin secretion evidence melatonin stabilises strengthens coupling circadian rhythms especially core temperature sleep wake rhythms circadian organisation physiological functions depend also melatonin signal instance immune antioxidant defences haemostasis glucose regulation difference physiological pharmacological effects melatonin always clear based upon consideration dose duration hormone message admitted physiological dose provides plasma melatonin levels order magnitude nocturnal peak since regulating system melatonin secretion complex following central autonomic pathways many pathophysiological situations melatonin secretion disturbed resulting alteration could increase predisposition disease add severity symptoms modify course outcome disorder since melatonin receptors display wide distribution body putative therapeutic indications compound multiple great advances field could achieved developing multicentre trials large series patients order establish efficacy melatonin absence long term toxicity elsevier masson sas rights reserved
paper describes low cost small scale spin rig rig housed steel vacuum chamber diameter powered variable speed electric motor small rig developed test experimental procedure data acquisition techniques investigate dynamic characteristics high speed rotating system using rig fan blade fbo experiments carried notched blade releasing mechanism investigated relationship notch depth release speed modified consideration notch concentration factor predicted release speed agreed reasonably well experimental data simple wire trigger method data acquisition developed synchronized high speed video images sensor signals fbo events obtained observed phenomena similar reported using larger spin rigs
present study examined service providers adherence components cognitive behavioral therapy cbt youth anxiety training postworkshop training months weekly consultation adherence measured using role play trained actor examined differences individual adherence cbt components across time relationship number consultation sessions attended adherence ratings consultation findings indicated somatic arousal identification relaxation used treatment components training adherence components cbt increased workshop training except usage problem solving adherence problem solving positive reinforcement identification anxious self talk creation coping thoughts increased consultation usage problem solving remained low compared treatment components overall adherence remained less optimal final measurement point number consultation sessions attended predicted postconsultation adherence identification somatic arousal identification anxious self talk positive reinforcement implications include tailoring future training based baseline levels adherence spending time training consultation underutilized cbt components problem solving limitations present study including adherence measured discussed study adds implementation science literature providing nuanced information changes adherence course training consultation service providers
electronic cigarettes ecigs use electricity power heating element aerosolizes liquid containing solvents flavorants dependence producing drug nicotine user inhalation ecigs evolved rapidly past years changes product design liquid constituents affect resulting toxicant yield aerosol delivery user rapid evolution accompanied dramatic increases ecig use prevalence many countries among adults especially adolescents united states increased prevalence ecigs deliver nicotine toxicants users lungs drives rapidly growing research effort review highlights recent information regarding design ecigs liquid aerosol constituents epidemiology ecig use among adolescents adults including correlates ecig use preclinical clinical research regarding ecig effects current literature suggests strong rationale empirical regulatory approach toward ecigs balances potential ecig mediated decreases health risks smokers use substitutes tobacco cigarettes increased risks nonsmokers may attracted
microelectronic product consumers may already expecting another paradigm shift smarter phones smart phones current status microelectronic manufacturing engineering education mmee universities hardly makes pace fast moving technology paradigm shift purpose mmee educate four year university graduates work microelectronics industry date knowledge self motivation paper present comprehensive curriculum four year university degree program area microelectronics manufacturing three hands experienced based courses proposed along methodology undergraduate students acquire hands experience towards integrated circuits ics design fabrication packaging presented consideration manufacturing engineering education semiconductor device circuit design course junior level designed cover designed circuits progress micro fabrication practicing full customization layout digital circuits hands experienced based semiconductor fabrication courses composed enhance students motivation participate self motivated semiconductor fab activities performing series collaborations finally microelectronics packaging course provides greater possibilities mastered skillsets area microelectronics manufacturing fabrication printed circuit boards pcbs board level assembly microprocessor applications evaluation presented comprehensive curriculum performed students survey students responded strongly agree agree manufacturing related courses development application presented curriculum past six years convinced students confidence obtaining desired jobs choosing higher degrees area microelectronics manufacturing increased confirmed hypothesis inclusion hands experience based courses mmee beneficial enhancing motivation learning
work assessed energy potential alternative usages biogas sludge generated upflow anaerobic sludge blanket reactors laboreaux sewage treatment plant stp brazil two scenarios considered priority use biogas thermal drying dehydrated sludge use excess biogas electricity generation ice internal combustion engine priority use biogas electricity generation use heat engine exhaust gases thermal drying sludge scenario showed electricity generated able supply stp power demand thermal drying process enables greater reduction even elimination final volume sludge disposed scenario electricity generated able supply stp power demand however heat exhaust gases enough dry total amount dehydrated sludge
objectives test impact specific maternal neonatal associated factors human milk macronutrients energy methods study conducted use human milk analyzer hma miris uppsala sweden six hundred thirty samples raw milk samples donor pasteurized milk delivered total mothers results significant inverse correlation fat protein energy content gestational age birth weight established fat energy lower colostrum increased transitional milk decreased day mature milk compared transitional rate protein decline colostrum mature milk lower premature deliveries compared full terms resulting greater contents protein preterm mature milk upmost amounts carbohydrates found mature milk preterm deliveries positive correlation found maternal age fat contents women higher post pregnancy bmi levels greater analogies fat energy presented women suffering diet controlled gestational diabetes lower protein higher fat energy levels found conclusions prematurity maternal age diet controlled high post pregnancy bmi levels found impose statistical significant effect milk macronutrients energy
vertical torsional vibration basic frequency estimation formula suspension bridge wind resistant design specification highway bridges introduced finite element model humen suspension established whole vibration models frequency obtained modal analysis lays foundation developing flutter analysis spectral analysis structure results comparisons specification finite element model show results agree well indicates specification estimation formula accurate reflect dynamic characteristics structure early design specification formulas used estimate fundamental frequency suspension bridge
recent world economic crises accelerated integration women labor force represented new challenge achievement work family balance aim present study analyze extent feasibility conciliate work family influence career choice level women employment mexico spain order achieve data family changing gender roles international research project analyzed using multinomial logistic regression model occupation treated dependent variable socioeconomic characteristics stereotypes gender roles household division labor treated independent variables main findings indicate lack work family conciliation increases likelihood women participation housewives countries international comparison showed gender bias asymmetry household division labor lead extra domestic work however activity consistent traditional gender roles associate women child rearing conclude even though mexico spain share certain cultural canons countries differences way conceptualizing conciliation family work also reflected differentiated regulatory framework
nearest neighbor knn one basic processes behind various machine learning methods knn relation query neighboring sample basically measured similarity metric euclidean distance process starts mapping training dataset onto one dimensional distance space based calculated similarities labeling query accordance dominant mean labels nearest neighbors classification regression issues respectively number nearest neighbors chosen according desired limit success nonetheless two distinct samples may equal distances query different angles feature space similarity query two samples needs weighted accordance angle going query samples differentiate two distances reference angular information opinion analyzed context dependency utilized increase precision classifier point view instead knn query labeled according nearest dependent neighbors determined joint function built similarity dependency method therefore may called dependent demonstrate applied synthetic datasets different statistical distributions benchmark datasets pima indian hepatitis approximate sinc casp datasets results showed superiority terms accuracy computation cost compared employed popular machine learning methods elsevier rights reserved
technical note proposes noise tolerant zeroing neural network ntznn design formula shows recurrent recursive methods solving time varying problems designed viewpoint control ntznn design formula provides control theoretic framework deal convergence stability robustness issues continuous time discrete time models ntznn models derived proposed design formula demonstrate advantages applied solving time varying zero finding problems presence noises
present report describes planning surgery well pitfalls management patient near total mandibular avulsion injury rehabilitated using three dimensional laser printing titanium lower jaw laser sintering involves zapping layers powdered metal recreate implantable skeletal defect process involves using either mirror imaging unaffected side using archival image database healthy individuals year old man presented gunshot injury left near total avulsed mandible patient received state art treatment using laser printed mandible connected muscles mastication functionality inner side titanium jaw filled patient comminuted fractured bones addition harvested iliac crest bone graft covered patient remaining periosteal tissue implantation near total mandible using laser printing fast predictable process selected patients result aesthetically well functionally excellent results authors believe future craniofacial reconstruction employ methods facial bony reconstruction
glutamatergic projections nucleus accumbens nac drive drug seeking behaviors opioids withdrawal modulating glutamatergic neurotransmission provides novel pharmacotherapeutic avenue treatment opioids dependence great deals researches verified transient receptor potential vanilloid trpv channels alters synaptic transmitter release regulate neural plasticity present study whole cell patch clamp recordings adopted examine activity trpv channels regulating glutamate mediated excitatory postsynaptic currents epscs nac rat morphine withdrawal days weeks data showed frequency spontaneous excitatory postsynaptic currents sepscs amplitudes evoked excitatory postsynaptic currents eepscs increased morphine withdrawal applied capsaicin trpv agonist capsaicin decreased paired pulse ratio ppr increased sepscs frequency amplitudes suggesting presynaptic locus action morphine withdrawal effects fully blocked trpv antagonist capsazepine additionally presence receptor antagonist depolarization induced release endogenous cannabinoids activated trpv channels enhance glutamatergic neurotransmission morphine withdrawal functional enhancement trpv channels facilitating glutamatergic transmission recorded dorsal striatum findings demonstrate ability trpv regulating excitatory glutamatergic transmission enhanced morphine withdrawal nac would deepen understanding glutamatergic modulation opioids withdrawal elsevier rights reserved
children must sometimes decide conforming peer behavior right research shows children strong inclination act prosocially help conspecifics need many studies also demonstrate children tend adopt peer behavior two studies investigated whether children would conform antisocial majority whether would right thing even peer pressure results show recipient need year old children act prosocially two different contexts even strong selfish incentive however severity recipient need reduced children conform antisocial group current studies suggest children prosocial motivation sometimes wins selfish drives elsevier inc rights reserved
cytoreductive therapies traditionally standard treatment older patients polycythemia vera history prior thrombosis hydroxyurea frequently used cytoreductive agent however approximately patients treated eventually develop resistance intolerance patients fail increased risk death transformation myelofibrosis acute myeloid leukemia interferon alpha used younger patients capable inducing complete hematologic response significant reductions even eradication jak mutation allele burdens small notable subset patients potential toxicities interferon alpha must weighed disease control benefit case case fashion recently jak inhibitor ruxolitinib demonstrated significant improvement controlling hematocrit splenomegaly versus best available therapy patients failed intolerant currently fda approved setting review discuss novel emerging therapies special focus currently available upcoming treatment options patients fail elsevier ireland ltd rights reserved
strong relationship scientific research technology advancement former generally focuses studying phenomena happening real world latter improves tools basis research perspective information communication technologies allow implementation ever faster tools analyzing data generated experiments aim demogrape project study interaction upper earth atmosphere gnss global navigation satellite systems signals received ground critical environments polar regions paper describes ict infrastructure used manage software applications used analyzed data collected project experimental campaigns taking account following constraints intellectual property applications must protected underlying infrastructure resembles cloud federation iii data sized provide unified vision available resources user available applications experimental data reside leveraging lightweight virtualization system proposed management system copes four constraints case study used show process deploying application proposed system specific node data interest reside
introduction neurologists frequently consulted patients white matter lesions discovered incidentally brain mri performed reasons suspecting demyelinating disease referring physician question person multiple sclerosis mri typical clinical symptoms signs suggestive demyelinating disorder patients diagnosed radiologically isolated syndrome ris areas covered timely review ris focus treatment considerations expert commentary multiple studies tried identify common predictive factors conversion ris clinical strongest thus far asymptomatic cervical spinal cord lesion treatment ris highly controversial early treatment carefully selected patients might improve long term outcome
parent child interaction therapy pcit evidence based family intervention young children disruptive behavior parents children complete pcit show greater immediate long term treatment gains discontinue treatment prematurely pcit time effort intensive treatment parents ambivalent value child ability master treatment skills may discontinue treatment engaging sufficiently experience change motivational interviewing client centered therapeutic method increasing motivation change resolution ambivalence paper describes clinicians may incorporate nit strategies pcit enhance parental motivation signs ambivalence arise vignettes scripted therapy exchanges illustrate use strategies decrease ambivalence pcit improve homework adherence increase parenting self efficacy reduce attrition thereby improving outcomes young children disruptive behaviors families
gut microbiota provides range ecologic metabolic immunomodulatory functions relevant health well gut microbiota responds quickly changes diet dynamic equilibrium may managed prevent treat acute chronic diseases article provides working definition term microbiome uses two examples dietary interventions treatment large bowel conditions emphasize links diet microbiome remains need develop better functional understanding microbiota management clinical utility fully realized
backgroundsleep disturbances well documented among persons irritable bowel syndrome ibs difficulty falling asleep shorter sleep time frequent arousal awakenings non restorative sleep common manifestations sleep disturbances also related higher risk ibs researchers provided evidence positive association poorer subjective sleep quality increased severity frequency gastrointestinal symptoms ibs however findings studies using objective sleep activity measures polysomnography actigraphy inconclusive purposethis systematic review literature evaluates evidence sleep disturbances adults ibs relationship symptoms
work motivated ozone production improvement dielectric barrier discharge supplied high voltage triggered pulsed generator particular attention focused ozone generator cell geometry type electrical generator comparative parametrical analysis two configurations reactor performed annular surface configuration study emphasizes surface discharges coupled ultra short triggered high voltage generators stand efficient process produce ozone large quantities
nanoscale visible light self sensing stress probe would highly desirable variety biological imaging materials engineering applications especially device alter mechanical properties material seeks probe present cdse cds tetrapod quantum dot incorporated polymer matrices via electrospinning situ luminescent stress probe mechanical properties polymer fibers mechanooptical sensing performance enhanced increasing nanocrystal concentration causing minimal change mechanical properties even incorporation tetrapod nanoprobe elastic recoverable undergoes permanent change sensing ability even upon many cycles loading failure direct comparisons side side traditional mechanical tests validate tetrapod luminescent stress probe tetrapod fluorescence stress strain curve shape matches well uniaxial stress strain curves measured mechanically filler concentrations reported
main goal radiotherapy destroy tumor minimizing harm nearby healthy tissue advances digital control enabled planning performing accurate treatments however todays technology unable compensate respiration induced motion therefore ensure sufficient precision one tasks compensating respiratory motion predicting position functional target tumor external marker fraction performance techniques pearson correlation gaussian filters fourries transformation cross correlation linear interpolation partial least squares still leave plenty space improvement reports results work progress experiments applying different types regressions predict motion functional target different external markers results seem promising cases
world engineering congress wec multidisciplinary engineering congress organized jointly faculty engineering universiti putra malaysia federation engineering institutions islamic countries institution engineers malaysia july city kuching sarawak malaysia first major multidisciplinary engineering event ever held country theme engineering innovation sustainability congress attracted technical papers attended delegates representing countries worldwide congress run parallel technical sessions field biological food engineering chemical environmental engineering civil structural engineering electrical electronic engineering engineering education training policy information communication technology manufacturing engineering automation robotics mechanical aerospace engineering common first day keynote papers presentations paper presents overview management organizational structure wec discusses advantages disadvantages multidisciplinary engineering congress appraises effectiveness event means communicating sharing knowledge
embryogenesis tissue maintenance repair adult organism myriad stem cells regulated surrounding extracellular matrix ecm enriched tissue organ specific nanoscale topographical cues adopt different fates functions attributed capability self renewal differentiation types somatic cells stem cells also hold tremendous promise regenerative medicine drug screening however major challenge remains achieve fate control stem cells vitro high specificity yield recent exciting advances nanotechnology materials science enabled versatile robust large scale stem cell engineering vitro developments synthetic nanotopographical surfaces mimicking topological features stem cell niches addition generating new insights stem cell biology embryonic development effort opens unlimited opportunities innovations stem cell based applications review therefore provide summary recent progress along research direction perspectives focusing emerging methods generating nanotopographical surfaces applications stem cell research furthermore provide review classical well emerging cellular mechano sensing transduction mechanisms underlying stem cell nanotopography sensitivity also give hypotheses regard multitude signaling events cellular mechanotransduction may converge integrated core pathways controlling stem cell fate response extracellular nanotopography elsevier ltd rights reserved
development power electronic technology control technology power electronic device becoming complicated switching power supply indispensable component modern power electronic equipment quality size direct impact whole performance electronic equipment digital control technology applications fpga become new research hotspot field power electronics digital control reduce aging device impact temperature drift accuracy convenient paper studies digital switching power supply based fpga points system structure system
seasonal affective disorder sad major depressive disorder recurring fall winter caused reduction light environment depressive symptoms alleviated bright light therapy circadian monoaminergic systems implicated etiology sad however underlying neural pathways light regulates mood well understood present study utilized diurnal rodent model arvicanthis niloticus explore neural pathways mediating effects light brain regions involved mood regulation animals kept constant darkness received light exposure early subjective day time light therapy usually applied time course neural activity following light exposure assessed using fos protein marker following brain regions cells suprachiasmatic nucleus scn orexin neurons perifornical lateral hypothalamic area lha dorsal raphe nucleus drn light induced increase fos expression observed orexin neurons drn scn drn densely innervated orexinergic inputs involvement orexinergic signaling mediating effects light drn tested second experiment animals injected selective orexin receptor type oxr antagonist prior light exposure treatment significantly inhibited fos induction drn results collectively point role orexin neurons mediating effects light mood regulating monoaminergic areas suggesting orexinergic pathway underlies light dependent mood fluctuation beneficial effects light therapy ibro published elsevier ltd rights reserved
background standard replacement therapy addison disease restore normal circadian rhythm periods sub supra physiological cortisol levels experienced patients likely induce disrupted sleep given healthy sleep plays important role memory consolidation novelty current study characterise using objective measures relationship sleep memory patients examine hypothesis poor sleep biological mechanism underlying memory impairment patients methods used within subjects design ten patients matched healthy controls completed standardised neuropsychological tests assessing declarative memory rey auditory verbal learning test procedural memory finger tapping task period actigraphymeasured sleep period waking results relative healthy controls patients experienced disrupted sleep characterised poorer sleep efficiency time spent awake patients also showed impaired verbal learning memory relative healthy controls furthermore whereas healthy controls declarative memory performance benefited period sleep compared waking patients derived benefit sleep regarding procedural memory task analyses detected significant group differences neither group showed significant sleep enhanced performance conclusions demonstrated using actigraphy standardized measures memory performance association sleep disturbances cognitive deficits patients results suggest patients source memory deficits least extent disrupted sleep patterns interfere optimal consolidation previously learned declarative information hence treating sleep disturbances frequently experienced patients may improve cognitive functioning elsevier ltd rights reserved
purpose context first sexual intercourse takes place lasting implications subsequent sexual behavior study examines adolescent disability associates boys age sexual debut relationship first sexual intercourse degree discussion birth control first sexual intercourse contraceptive use first sexual intercourse methods data used national longitudinal survey youth nationally representative survey collected annually united states multinomial logistic regression base sample boys examines likelihood sexual debut ages years first intercourse stranger casual acquaintance dating partner committed relationship undefined relationship level discussion birth control contraception condom use among contracept results compared boys without disability learning emotional conditions likely sensory conditions less likely report early sexual debut boys chronic illness likely sex committed relationship undefined relationship also likely contracept first intercourse boys learning emotional conditions likely discuss birth control less likely use condoms contracept conclusions boys without disabilities boys different types disabilities vary significantly multiple aspects first sexual experiences pertinent sexual health interventions tailored address diversity society adolescent health medicine rights reserved
individuals merely passive vessels whatever beliefs opinions exposed rather attracted belief systems resonate psychological needs interests including epistemic existential relational needs attain certainty security social belongingness jost glaser kruglanski sulloway demonstrated needs manage uncertainty threat associated core values political conservatism namely respect tradition acceptance inequality since far studies psychology left right ideology preceding half century empirical yield helps address lingering questions criticisms identified studies epistemic motivation involving individual participants nearly studies existential motivation involving participants databases much larger heterogeneous used previous meta analyses confirm significant ideological asymmetries exist respect dogmatism cognitive perceptual rigidity personal needs order structure closure integrative complexity tolerance ambiguity uncertainty need cognition cognitive reflection self deception subjective perceptions threat exposure objectively threatening circumstances terrorist attacks governmental warnings shifts racial demography contribute modest conservative shifts public opinion also ideological asymmetries relational motivation including desire share reality perceptions within group consensus collective self efficacy homogeneity social networks tendency trust government one political party power although object notion meaningful psychological differences leftists rightists identification elective affinities cognitive motivational processes contents specific belief systems essential study political psychology political psychologists may contribute development good society downplaying ideological differences advocating swiss style neutrality comes human values investigating phenomena critically even perhaps especially pressure society view uncritically
enactment patient protection affordable care act aca expected improve coverage health insurance particularly related coordination seamless care continuity elder care among medicare beneficiaries analysis longitudinal data rural areas offers unique opportunity examine trends patterns rural disparities hospital readmissions within days discharge among medicare beneficiaries served rural health clinics rhcs eight southeastern states department health human services dhhs region purpose study twofold first examine rural trends patterns hospital readmission rates state year aca enactment second investigate contextual county characteristic organizational clinic characteristic ecological aggregate patient characteristic factors may influence variations repeat hospitalizations unit analysis rhc used administrative data compiled multiple sources centers medicare medicaid services period seven years risk adjusted readmission rates increased slightly among medicare beneficiaries served rhcs however rate declined generalized estimating equation sixteen predictors analyzed variability risk adjusted readmission rates nine predictors statistically associated variability risk adjusted readmission rates rhcs pooled together declined rates associated aca effect georgia north carolina south carolina percentage elderly population county rhc located however increase risk adjusted rates associated percentage african americans county percentage dually eligible patients average age patients average clinical visits african american patients sixteen predictors accounted total variability readmissions study contributes literature health disparities research contextual organizational ecological perspectives analysis longitudinal data synergism multiple contextual organizational ecological factors shown study considered design implementation intervention studies address problem hospital readmissions prevention enhancement disease management rural medicare beneficiaries
recent study corresponding author found peek bearing elements revealed high irreversible surface strains loaded steel sheets since reflects conditions practical application rolling properties dominated surface material detailed analysis highly strained peek required hence fatigue tests high stress tensile regime conducted experiments carried servo hydraulic testing machines tests mechanical response specimens recorded two material modifications peek investigated research untreated peek without heat treatment annealed peek modified using defined thermal conditions analysis recorded test data aimed distinction cumulative material response creep deformation material hardening softening spontaneous material response material hardening softening highest stress levels cumulative response pretended material softening increasing number cycles however examining spontaneous material response became stiffer increasing number cycles shown cumulative softening caused time dependent deformation processes
paper comparative optimal design permanent magnet motors pmms aerospace actuation applications based single double layer fractional slot concentrated winding fscw topologies different motor segmentation strategies undertaken means combined electromagnetic fault tolerance thermal evaluation initially analytical machine equations finite element analysis employed determination motors basic dimensional operating characteristics configurations considered next step optimized regarding mean torque efficiency torque ripple induced electromotive force emf quality motor weight proposed methodology involves appropriate handling mean torque induced emf constraints application particular single objective particle swarm optimization pso technique accounting also multiple motor operating conditions fault tolerance thermal robustness optimized motors also examined single layer double layer fscw pmm optimal configurations present complementary advantages class applications
novel estimator identification continuous time linear time varying systems presented paper estimator uses kernel based regression identify time varying coefficients linear ordinary differential equation based noisy samples input output signals estimator adopts mixed time frequency domain formulation allows formulated solution set algebraic equations without relying finite differences approximate time derivatives since kernel based approach used model complexity selection time varying parameters formulated optimisation problem continuous variables variance bias expressions estimate derived validated simulation example also shown highly noisy environments proposed kernel based estimator provides reliable results oracle based estimator deprived regularisation
first two part simulation study discusses application multimode combustion engine mild hybrid electric vehicle hev torque assist offered electric motor used extend residence time homogeneous charge compression ignition hcci regime returning spark ignition combustion enable multimode operation hev supervisory control strategy maintain battery state charge accounting hcci combustion mode switch study four supervisors discussed extend baseline equivalent consumption minimization strategy mode switching decision elsevier ltd rights reserved
borderline personality disorder bpd severe mental disorder multifactorial etiology development maintenance bpd sustained diverse neurobiological factors contribute disorder complex clinical phenotype factors may identified using range techniques probe alterations brain systems underlie bpd systematically searched scientific literature empirical studies neurobiology bpd identifying articles three broad research areas neuroendocrinology biological specimens structural neuroimaging functional neuroimaging consolidate results studies provide integrative model attempts incorporate heterogeneous findings model specifies interactions among endogenous stress hormones neurometabolism brain structures circuits involved emotion cognition role amygdala bpd expanded consider functions coordinating brain dynamic evaluation relevance emotional stimuli context individual goals motivations future directions neurobiological research bpd discussed including implications research domain criteria framework accelerating genetics research incorporating endophenotypes gene environment interactions exploring novel applications neuroscience findings treatment research
single multilevel cervical corpectomy treatment different diseases many surgical options proposed years single device winged expandable titanium cage wetc developed report use device clinical results months follow prospective series patients underwent single multilevel corpectomy treatment cervical spondylosis thirty four consecutive patients underwent single multilevel cervical corpectomy followed insertion wetc treatment cervical spondylosis department neurology psychiatry sapienza university rome italy may may patients affected cervical spondylosis cervical lordosis degrees included patients affected cervical lordosis degrees osteoporosis cervical diseases excluded mean postsurgical nurick grade significantly lower mean presurgical nurick grade mean postsurgical nurick grade mean presurgical nurick grade four patients presented subsidence respectively months radiological follow postoperative complications occurred five patients case series months follow demonstrates use wetc obtains good clinical results single multiple corpectomy patients affected osteoporosis require cervical lordosis correction insertion device adequate preparation end plates suggested distraction avoided
objective review current literature pathogenesis mucormycosis discuss diagnostic strategies evaluate efficacy polyenes triazoles echinocandins pharmacological treatment options data sources electronic literature search conducted pubmed using mesh terms rhizopus zygomycetes zygomycosis mucorales mucormycosis search terms amphotericin micafungin anidulafungin caspofungin extended infusion amphotericin liposomal amphotericin combination therapy triazole posaconazole isavuconazole diagnosis clinical manifestations study selection data extraction studies written english language january march considered review article search results reviewed relevance article determined authors independently data synthesis mucormycosis rare invasive fungal infection exceedingly high mortality therapeutic options distinct predilection invasion endothelial cells vascular system likely important dissemination disease primary focus infection six distinct clinical syndromes occur susceptible hosts including rhino orbital cerebral pulmonary gastrointestinal cutaneous widely disseminated miscellaneous infection conclusion diagnosis mucormycosis typically difficult make based imaging studies sputum culture bronchoalveolar lavage culture needle aspirate surgical debridement prior dissemination infection improves clinical outcomes surgery combined early high dose systemic antifungal therapy yields greater fold increase survival rates mucorales inherently resistant widely used antifungal agents amphotericin appropriate empirical therapy whereas posaconazole isavuconazole best reserved escalation refractory cases patients intolerant amphotericin
background aims need simple practical tool adapted diagnosis chronic constipation asian population study compared asian neurogastroenterology motility association anma tool rome iii criteria diagnosis asian subjects methods multicenter cross sectional study included subjects presenting outpatient gastrointestinal clinics across asia subjects alert symptoms completed combination diagnosis questionnaire obtain diagnosis based different diagnostic methods self defined investigator judgment anma tool rome iii criteria primary endpoint level agreement disagreement anma diagnostic tool rome iii criteria diagnosis results primary analysis comprised subjects positive diagnosis according anma tool rome iii positive anma positive rome iii negative anma negative diagnoses reported subjects respectively resulting overall percentage agreement diagnostic methods overall percentage disagreement diagnostic methods higher level agreement seen anma tool self defined subjects investigator judgment criteria subjects compared rome iii criteria conclusion study demonstrates anma tool useful asian patients
group recently developed novel covered carotid stent prevent emboli preserving external carotid artery eca branch blood flow however recent vitro side branch eca flow preservation tests covered stents revealed need stent frame design improvements including consideration crimp stent low profile delivery stent system bigger cells hence current work aims design new bare metal stents bigger cell size improve crimpability accommodate slits side branch flow could increased three new stent designs analyzed using finite element analysis benchmarked two commercially available carotid stents terms mechanical performances crimpability radial strength flexibility results indicated new bare metal stent designs matched well commercial stents hence new generation covered stents based designs expected perform better side branch flow preservation without compromising mechanical performances
work part methodological renovation project ingenieria fabricacion innovative education group university las palmas gran canaria developed learning materials courses manufacturing engineering used several degrees first learning material decided take plastic injection mould teaching resource summarized design manufacture plastic injection product whilst developing teaching material aimed explain necessary stages make injection mould well manufacturing processes related work generated lot educational material laboratory practices multimedia abundant information generated used develop interactive electronic publication finally learning material chosen publishing scientific diffusion service university new line work publications educational innovation authors published elsevier ltd
development renewable power generation systems rpgss continually increasing worldwide germany china japan italy usa leaders contributing largest development region due increasing number rpgss connected utility grid power quality safe operation islanding protection rpgss becoming important issues among others one important elements current control technique must meet requirements grid interconnection according international standards practices rpgs must safe highly efficient reliable secure grid interconnection operations paper presents review state art current control techniques three phase grid interconnection rpgss several current control architectures operations including advantages disadvantages discussed performance comparison evaluation several controllers also reviewed elsevier ltd rights reserved
purpose paper review practice theory inventive problem solving triz green supply chain gsc problems identify new research challenges focusing question extent necessary evolve triz tools methods theoretical grounding addressing gsc inventive problems first review past contributions triz based methods gsc problem resolution presented result papers review provide comprehensive understanding limitations areas potential application triz gsc three experiments conducted complete literature review order provide comprehensive answer posed question identify research challenges experiments addressing gsc problems also conducted explore extent mature meta methods classical triz namely ariz related sub methods used gsm problems examples chosen explore types gsc problems yet addressed triz experiment results highlight limitations use triz gsc inventive problems mentioned gsc literature moreover highlights limitation using mature meta methods triz ariz ariz conflict overcome contains two evaluation parameters one action parameter finally research challenges overcome limitations improve use triz gsc inventive problems stated among methods quickly establishing existence classical triz contradictions informing problem solver triz contradictions present given inventive problem gsc proposed methods would permit determining whether ariz could used avoid long fruitless search system contradictions find alternatives algorithms proposed past able establish generalized contradictions inventive problems make evolve meta methods ariz substitute methods address inventive problems treated ariz elsevier ltd rights reserved
performances chloramphenicol cap degradation direct ultraviolet irradiation persulfate oxidation alone irradiation activated persulfate process systematically studied oxidation superior direct irradiation oxidation alone center dot center dot existing system center dot proved primary radical species scavenging tests secondary order reaction rate constant cap center dot estimated cap degradation fitted pseudo first order kinetics well tests higher dosage lower initial cap concentration acid promoted cap degradation maximum toc removal observed min conditions cap last electrical energy per order value system demonstrated kwh order results indicated system potential alternative control water pollution caused emerging contaminants cap elsevier rights reserved
objective determine nursing care missed perceived nursing staff relation nursing care missed identified assessment patients risk pressur ulcers method descriptive correlation study participants nurses patients public hospital misscare survey used combination nursing care assessment form patients risk pressure ulcers analysis descriptive inferential statistics used results nursing staff indicated greater omission skin care position change registration risk factors development pressure ulcers nursing care missed identified assessment related use pressure relief bony prominences drainage tubes interfering patient movements use pneumatic mattresses conclusion high percentage nursing care missed found according staff perception nevertheless assessment nursing care missed much higher significant relation found therefore priority reflect importance objective patient assessments
paper analyse patterns face shape variation due weight gain propose use persistent homology descriptors get geometric topological information configuration anthropometric face landmarks way evaluating face changes boils comparing descriptors computed face scans taken different times applying dimensionality reduction techniques dissimilarity matrix descriptors get space face point face shape variations encoded trajectories space results show persistent homology able identify features well related overweight may help assessing individual weight trends research carried context european project semeoticons developed multisensory platform detects monitors time facial signs cardio metabolic risk
hornik hajkova anisimov rybnicek ctu prague faculty mechanical engineering department materials engineering icdam prague czech republic causes inconel weld cracking problems related welding duplex steel alloy inconel described gtaw welding procedure used root smaw main weld weldment characterized tendency weld metal cracking smaw region bend test microstructural analysis weld performed supplemented nanohardness measurements charpy impact test fractographic analysis carried microstructure weld exhibited presence hard particles mostly oxide region smaw region presence negative effect ductility weld oxide presence probably caused technological discrepancy
background striking gender disparity incidence outcome primary liver cancer plc well recognized mounting evidence basic research suggests hormonal factors may involved gender disparity plc whether hormonal exposures human subjects associated plc risk largely unknown objective rationale whether reproductive factors use menopausal hormone therapies mhts women associated plc risk remains controversial conducted study clarify issue search methods pubmed embase searched july studies published english chinese observational studies cohort nested case control case control provided risk estimates reproductive factors mhts plc risk eligible quality included studies determined based newcastle ottawa quality assessment scale summary risk ratios rrs calculated using random effects model dose response analysis conducted possible outcomes fifteen peer reviewed studies involving plc cases women included overall meta analyses parity plc risk find significant associations however restricting studies plc cases increasing parity found significantly associated decreased risk plc highest versus lowest parity parous versus nulliparous per one live birth increase shaped relationship parity plc risk identified pnon linearity compared never users pooled rrs plc ever users mht ever users estrogen therapy ever users estrogen progestin therapy ept pooled plc oldest versus youngest category menarcheal age oophorectomy significantly associated increased risk plc significant association age first birth spontaneous induced abortion plc risk found meta analysis performed association age menopause breastfeeding hysterectomy menopausal status stillbirth plc risk owing huge methodological heterogeneity limited studies wider implications parity associated plc risk shaped dose response pattern late age menarche ever use mht associated reduced risk plc whereas association ever use ept age first birth spontaneous induced abortion plc risk compared women history oophorectomy history oophorectomy increased risk plc findings provide epidemiological support role hormonal exposures development plc women however findings interpreted much caution limited number studies potential biases need validated studies good design large sample size
smart home field witnessed rapid developments recent years internet things applications smart home heterogeneous continuously increasing number making user management security perspective challenging moreover resource constrained nature devices implies security mechanisms deployed lightweight highly efficient article propose authentication scheme based symmetric key cryptography combined capability based access control system provide different stakeholders residents recurring guests temporary guests end end secure access internet things devices smart home managed home owner anonymous way operations scheme include small number communication phases protect identities entities involved stakeholders end nodes outside entity proposed scheme ensures even stakeholder device internet things device attacked system remains secure
background purposecerebrospinal fluid csf brain compartmentalized two main divisions ventricular csf subarachnoid space sulcal csf changes csf volumetry seen many neurological conditions including multiple sclerosis found correlate clinical outcomes aimed test relation volumetry sulcal ventricular csf cognitive impairment based minimal assessment cognitive function macfims patients material methodsforty six patients underwent macfims battery classified nonimpaired msni cognitively impaired msci borderline msbd patients volumes sulcal ventricular csf along global gray white matter volumes cortical thickness obtained diffusion tensor imaging dti weighted based segmentation measures statistically analyzed associations adjusting age education years lesion load disease duration resultssulcal csf showed strongest correlation cohort whereas ventricular csf along cortical thickness gray matter volume failed show significant correlation group analyses unadjusted multiple comparisons showed significant difference volumes sulcal csf ventricular csf msni msci groups conclusionsulcal csf correlates patients possibly explained cortical atrophy dti based sulcal csf segmentation method might used indirect simple neuroimaging marker monitor patients
parkinson disease progressive neurodegenerative disorder characterized loss dopaminergic daergic neurons substantia nigra gradual depletion dopamine current treatments replenish deficit improve symptoms induce dyskinesias time neuroprotective therapies nonexistent report nuclear receptor related nurr retinoid receptor alpha rxr alpha activation double therapeutic potential offering neuroprotective symptomatic improvement designed brf unique vivo active nurr rxr alpha selective lead molecule prevents daergic neuron demise striatal daergic denervation vivo causing toxins nurr dependent manner brf also protects related genetic mutations patient induced pluripotent stem cell ipsc derived daergic neurons genetic mouse model remarkably besides neuroprotection brf regulates tyrosine hydroxylase aromatic amino acid decarboxylase aadc gtp cyclohydrolase gch transcription increases striatal vivo symptomatic efficacy two postneurodegeneration models without inducing dyskinesias chronic daily treatment combined neuroprotective symptomatic effects brf identify nurr rxr alpha activation potential monotherapeutic approach
shown negative capacitance circuits systematically used improve gain bandwidth product operational amplifiers opamps circuit moves nondominant pole opamp higher frequency decreasing parasitic capacitance critical node impedance input circuits neither purely capacitive negative frequencies design guide presented deriving circuit model conventional circuit investigating extent improvement achieved circuit use circuit model used present design guide widebanding multistage opamps large capacitive loads based proposed method three stage opamp capacitive load designed fabricated cmos process measurements confirm opamp satisfies design target mhz bandwidth power consumption
previously developed bio pick place perfuse bio instrument fabricate large perfusable tissue constructs stacking aligning scaffold free living microtissues integrated lumens bio required actuating mechanism manipulate living microtissues various sizes shapes fragile must remain aqueous environment optical transparency bio gripping device essential provide unobstructed visuals accurate alignment microtissues previously engineered pilot fluid force driven bio gripper pick place microtissue planar position without causing cellular damage pulling culture medium track etched membrane integrated cell culture inserts study invented new flexible bio gripper design maximized bio gripper utilities utilized experimental approaches multivariate analyzes theoretical modeling elucidate membrane characteristics pore size pore density membrane thickness membrane area surface chemistry altered bio gripper robustness flow rate required successful gripping devised two standardized tests synthetic parts mimicked microtissues systematically quantify bio gripper performance thirteen syringe pump driven bio grippers except one successfully gripped released synthetic parts values coincided mathematical simulation fluid mechanics gripping bio gripper could grip synthetic parts various sizes shapes masses demonstrating robustness actuating mechanism multivariate analysis experimental data indicated membrane porosity thickness modulated addition revealed membrane pore density determined membrane optical transparency fabricating large tissue constructs requires repeated stacking microtissues showed one bio gripper could pick place living microtissues thirty times corresponding simulation bio gripper capable stacking aligning twenty microtissues summary successfully engineered robust controllable fluid driven bio gripper efficiently manipulate living microtissues micro objects aqueous environment
genus roseburia consists obligate gram positive anaerobic bacteria slightly curved rod shaped motile means multiple subterminal flagella includes five species roseburia intestinalis hominis inulinivorans faecis cecicola gut roseburia spp metabolize dietary components stimulate proliferation metabolic activities part commensal bacteria producing short chain fatty acids especially butyrate affecting colonic motility immunity maintenance anti inflammatory properties modification roseburia spp representation may affect various metabolic pathways associated several diseases including irritable bowel syndrome obesity type diabetes nervous system conditions allergies roseburia spp could also serve biomarkers symptomatic pathologies gallstone formation probiotics restoration beneficial flora
background acyclovir widely used treat infections caused herpes simplex virus hsv varicella zoster virus vzv common adverse effects drug include nausea diarrhea headache dizziness mental changes immune thrombocytopenia induced acyclovir rare case presentation year old chinese male given acyclovir hourly intravenously treatment vzv infection developed severe thrombocytopenia fist sign oral cavity within days starting using acyclovir patient condition improved stopping using acyclovir supportive treatment acyclovir dependent platelet antibody test showed positive results implicated acyclovir causative agent final definitive diagnosis acyclovir induced immune thrombocytopenia established basing time correlation start using acyclovir onset symptoms thrombocytopenia combining excluding common causes thrombocytopenia conclusion reports acyclovir induced immune thrombocytopenia first case report literature review acyclovir induced immune thrombocytopenia tongue hematoma first sign dentists never overlook rare adverse effect acyclovir rapid appropriate treatment may prevent severe life threatening complications
indigenous first nations people canada high chronic disease morbidity resulting part enduring social inequities colonialism obesity prevention strategies developed first nations people crucial improving health status group research objective develop community relevant strategies address childhood obesity first nations community strategies derived action based workshop based analysis grid environments linked obesity angelo framework thirteen community members wide ranging community representation took part workshop combined personal knowledge experience community specific national research dissect broad array environmental factors influenced childhood obesity community developed community specific action plans focusing healthy eating physical activity children families actions included increasing awareness children health issues among local population community leadership promoting nutrition physical activity school improving recreation opportunities strengthening children connection culture considered paramount improving well thus workshop participants developed programmes included elders teachers reinforced families acquaintance first nations foods activities research demonstrated angelo framework participatory way develop community driven health programmes also demonstrated first nations people involved creation solutions health issues communities may focus decolonising approaches strengthening connection indigenous culture traditions external funds available implement programmes formal follow determine community members implemented programmes future research needs examine extent community members implement programmes whether community action plans implemented lead short long term benefits health outcomes
paper presents full partial load exergy analysis hybrid sofc power plant plant basically consists air compressor fuel compressor several heat exchangers radial gas turbine mixers catalytic burner internal reforming tubular solid oxide fuel cell stack bypass valves electrical generator inverter model accurately described special attention paid calculation sofc overpotentials maps introduced properly scaled order evaluate partial load performance turbomachineries plant simulated full load part load operation showing energy exergy flows trough components thermodynamic properties key point full load operation maximum value electrical efficiency achieved three different part load strategies introduced design operation achieved handling following parameters air mass flow rate fuel mass flow rate combustor bypass gas turbine bypass avoiding use variable speed control system results showed efficient part load strategy corresponded constant value fuel air ratio hand lower value net electrical power nominal load could achieved reducing fuel flow rate constant air flow rate strategy produces electrical efficiency drop becomes elsevier rights reserved
although increasing number hiv infected people accessing antiretroviral treatment many achieve complete hiv viral suppression remain risk aids capable hiv transmission food insecurity identified potential risk factor poor virologic response association factors inconsistently documented literature systematically searched five electronic databases bibliographies relevant studies april retrieved studies met inclusion criteria nine studies conducted north america remaining two studies brazil uganda respectively meta analyzed results indicated experiencing food insecurity resulted lower odds achieving complete hiv viral suppression significant inverse association consistently found regardless study design exposure measurement confounder adjustment methods findings suggest food insecurity potential risk factor incomplete hiv viral suppression people living hiv
military dependent children remain largely unexplored subject particularly early childhood education effort fill gap current literature research study focuses early childhood teachers perceive educational needs military dependent children previous research areas geographic mobility parental separation socioemotional needs reviewed used platform study study includes survey developed researcher used conjunction teacher observation classroom adaptation checklist examine needs children perceptions teachers results study demonstrate early childhood teachers perceive significant difference military nonmilitary dependent children socioemotional domains prosocial behavior concentration disruptive behavior believe difference related stability additionally early childhood teachers noted negative socioemotional academic impact related parental separation negative academic impact related geographic mobility teachers responses indicated mixed beliefs social impact frequent relocations
signal flow graph synthesis procedure generating voltage current mode filters using four terminal floating nullors ftfns presented novel networks realize second order voltage current mode filters given presented circuits element values expressed terms second order transfer function coefficients grounded capacitors elsevier science ltd rights reserved
gromov hausdorff distance two compact metric spaces measure far spaces isometric extensively studied field metric geometry recent years lot attention devoted computational aspects gromov hausdorff distance one prominent applications problem shape matching goal decide whether two shapes given polygonal meshes equivalent certain invariances therefore many methods proposed heuristically estimate gromov hausdorff distance metric spaces induced shapes however computational complexity computing gromov hausdorff distance yet thoroughly investigated show standard complexity theoretic assumptions determining gromov hausdorff distance two finite metric spaces approximated within reasonable bound polynomial time furthermore discover attributes metric spaces major impact complexity instance enables develop approximation algorithm fixed parameter tractable respect corresponding parameters
study presents self testing platform foreground digital calibration technique successive approximation register sar analog digital converters adcs high accuracy digital analog converter dac digital control used proposed self testing platform generate sinusoidal test signal signal implemented using arduino board clock signal generated test adcs addition fast fourier transform recursive discrete fourier transform rdft processors adopted dynamic performance evaluation calibration adcs third harmonic distortion caused non linearity track hold circuit mismatch dac capacitor array direct current offset comparator calculated using processors improve adc performance advantages proposed platform include low cost high integration need extra analogy compensation circuit deal calibration work bit sar adc rdft processor used taiwan semiconductor manufacturing ltd tsmc standard complementary metal oxide semiconductor cmos process sampling rate validate proposed method measurement results show signal noise distortion ratio calibration calibration
involvement tendons tendon sheaths frequently found common inflammatory systemic diseases rheumatoid arthritis spondyloarthritis rheumatoid arthritis tendon manifestations occur tenosynovitis swelling pain tendons mainly hands feet spondyloarthritis involvement tendons presents enthesitis pain swelling directly attachment points tendons bony structures commonly lower extremities pathological alterations tendons normally visualized sonography sometimes magnetic resonance imaging mri scintigraphy furthermore important diagnostics effective therapy detect joints involved means clinical sonographic radiological examination well laboratory parameters inflammation antibody serology anti ccp antibodies hla histopathological alterations tendinopathy rheumatic diseases differ degenerative posttraumatic tendinopathy expression changes however clear differentiation different rheumatic inflammatory systemic diseases histopathologically possible therapeutically systemic medication important part treatment rheumatic diseases local therapeutic measures employed treatment tenosynovitis enthesitis case failure lack efficacy medication conservative therapy tenosynovectomy performed persistent tenosynovitis reconstructive surgical procedures necessary tendon ruptures
side channel attacks emerged nondestructive threats security vulnerability cryptographic hardware paper provides overview protection techniques counter ways utilizing sidechannel information leakage combatting side channel attacks well securing authenticity devices counterfeits even falsification
clinical practice sketches support physicians treatment planning example employed direct annotations medical image data however approach leads occlusions case spatially complex representations anatomical structures vascular systems overcome limitation developed framework enables physician create annotations freely sketching environment solve problem occlusions animated representation original unfolded vascular structure interactive unfolding use semi immersive stereoscopic display stylus ray based interaction techniques
monitoring water quality important control water pollution contamination aquatic system large effect human health environment european water framework directive wfd related directive environmental quality standards eqs field water policy need sensitive reference methods highlighted since tributyltin tbt one wfd listed priority substances method developed capable qualify quantify pollutant required low wfd eqs whole water bodies non filtered water samples dissolved organic carbon suspended particulate matter therefore special attention paid interaction tbt suspended particulate matter humic substances obtain complete representation pollution surface waters different water samples investigated varying content organic dissolved suspended matter quantification performed using species specific isotope dilution ssid gas chromatography inductively coupled plasma mass spectrometry icp different sample treatment strategies evaluated compared process internal standard addition investigated optimized hence equilibrium internal standards matrix primary importance perform accurate ssid samples spiked eqs level analyzed recovery additionally real surface water samples investigated tbt concentration whole water body determined compared conventional routine analysis method elsevier rights reserved
voice commanded electronic wheelchair controller implemented controlled remotely voice commands google speaker independent voice recognition engine gps guiding google map bluetooth communication technology used smart phone programed used remote controller seven voice commands left right forward backward faster slower stop commands used word command increase recognition accuracy information location moved distance chair shown google map command recognition time smart phone one seven commands measured changing number several voice commands recognition time one seven commands measured recognition time forward command phone milliseconds wheelchair controlling module built electric circuit board atmega microcontroller system tested measuring response time system bps bluetooth communication phone wheelchair control module combined time voice recognition response smart phone wheel chair control module milliseconds forward command although google voice recognition engine worked well experiment performed quite environment road condition research required improving recognition error rate noisy road condition avoid dangerous accident misunderstanding commands emergency
background aims mucosal healing important goal patients crohn disease yet incompletely characterised investigated whether differed segments across colon ileum patients received adalimumab maintenance treatment extend study methods double blind study adults moderate severe ileocolonic mucosal ulceration patients received adalimumab induction week week week patients randomised adalimumab placebo every week week post hoc analysis assessed endoscopic index severity cdeis simple endoscopic score ses colonic ileal global histologic disease activity scores cghas ighas results baseline endoscopic severity similar across segments week mean changes cdeis surface involved ulcerated surface rectum sigmoid left colon transverse colon compared right colon ileum favourable shifts week ulcer size ulcerated surfaces per ses pronounced rectum sigmoid left colon transverse colon right colon ileum week cghas ighas healing common colon ileum conclusions analysis suggests differing propensities ileocolonic segments heal endoscopically adalimumab treatment sigmoid left transverse colon higher rates may achieved compared ileum patients moderate severe
background study aimed explore clinical implication chromosome microarray analysis cma genetically etiological diagnosis children congenital heart disease chd methods total children chd without multiple congenital anomalies mca intellectual disabilities developmental delay normal karyotype investigated using affymetrix cytoscan array result pathogenic copy number variations pcnvs identified children detection rates children simple chd complex chd respectively detection rates pcnvs isolated chd chd plus mca chd plus chd plus mca respectively pcnvs rate chd plus significantly higher isolated chd two genomic loci including deletion deletion considered chd locus dvl ski stim ctnna pln identified candidate genes associated chd phenotypes conclusion cma increase diagnostic rate improve etiological diagnosis children chd suggest cma first tier test children chd especially children chd plus
research focused showing physiological reactivity romanian young exposed short terra aggressive news involving blood method participants students faculty psychology educational sciences university bucharest aged males females instruments followings laffayette polygraph platinum series video stimuli recorded romanian news highest rated broadcasting news scheduled hours afternoon results applying wilcoxon nonparametric test dependent experimental groups hypotheses regarding statistically significant differences gsr blood pressure exposure news involving blood aggression confirmed findings provide evidence parents teachers prohibit children watching news involving blood aggression replace educational cultural kind news
objectives current recommendations healthy sleep school aged children predominantly focused optimal sleep duration however given importance routine circadian health stability sleep wake schedules may also important especially daytime behavioral functioning examined relationship short sleep duration sleep schedule instability behavioral difficulties community sample australian children methods children aged years without chronic health psychological conditions recruited primary schools adelaide south australia parent report questionnaire used assess sleep wake behavior behavioral functioning assessed using strengths difficulties questionnaire results children met sleep duration recommendations approximately reporting weekly variability bed rise times reported children multinomial regression analysis revealed sleep duration min bed rise time variability min significantly increased risk scoring percentile behavioral subscales conclusions inconsistent sleep schedules common similar short sleep duration associated behavioral difficulties considering lack study area research needed development new recommendations education sleep health messages elsevier rights reserved
according press release building sector accounts global primary energy consumption energy savings achieved building sector improving building dynamic energy performance terms sustainable construction management urban based built environments referred urban organism study implements concept dynamic approach reflect unexpected changes climate energy environments well energy policies technologies research area significant future building energy environmental industries around world however lack studies perspective dynamic approach system integration thus study designed fill research gap study highlights state art major phases building dynamic energy performance monitoring diagnosing retrofitting phases focusing operation maintenance phase study covers wide range research works provides various illustrative examples monitoring diagnosing retrofitting building dynamic energy performance finally study proposes specific future developments challenges phase suggests future direction system integration development carbon integrated management system large complex system expected researchers practitioners understand adopt holistic approach monitoring diagnosing retrofitting building dynamic energy performance new paradigm urban organism elsevier ltd rights reserved
labor productivity profound impact construction management accurate prediction productivity essential effectively plan operations depend time cost critical success construction project contractor owner however predicting productivity operations challenging due multiple characteristics workers interrelationships workers site conditions impact performance crews affect project goals paper proposes methodology quantify factors affect productivity masonry construction considered three factors compatibility suitability craft standardized data collection techniques used consolidate data three masonry sites mathematically define productivity function relates workers characteristics crews site conditions function increasing arguments determines factors affect masonry productivity factor effects interesting part able identify convexity properties function theoretical interpretation implications impact superintendent decisions forming crews proposed mathematical function enable superintendents better plan schedule manage masonry crews authors published elsevier ltd
around million individuals hepatitis virus hcv represents similar world population including similar million people usa according regional office middle east egypt highest prevalence world prevalence adults effective vaccine hcv combination peg interferon ribavirin least weeks standard therapy failed patients high cost serious side effects recent introduction direct acting antivirals daa resulted major advances toward cure hcv however relapse reduced antiviral efficacy fibrotic cirrhotic hcv patients addition undesired effects restrain full potential combinations need new approaches combinations different daa targeted delivery using novel nanotechnology approaches review role nanoparticles carrier hcv vaccines anti hcv combinations targeted delivery discussed
nonlinear dynamic coupled model hydropower station system contains model water carriage system water turbine system speed governor system generator electromagnetic system grid shaft system hydroelectric generating set well powerhouse established paper firstly simultaneous differential equations coupled hydraulic mechanical electric transient process set based upon theories hydraulics electrical machinery etc coupled structural models shaft system unit powerhouse built means finite element method secondly new method investigating nonlinear dynamic properties structures influenced coupled hydraulic mechanical electric factors different conditions introduced help user programmable features ansys software finally order verify rationality several numerical calculation methods used study starting process hydropower station results indicate model presented paper adoptable simulating specified condition reflect nonlinear dynamic characteristics hydropower station comprehensively addition model also used assess operation safety predict structures reliability hydropower station system provide profitable reference dynamic regulation limited transient conditions hydropower station
monitoring vital signs include breathing often used clinical practice home paper presents novel low power system used control breathing frequency detect apnea uses condenser type humidity sensor supplied input bias current operational amplifier new configuration sensor compensates amplifier saturation state exhalation phase increases breath detection effectiveness presented system energy efficient consumes approx operates wide range supply voltages divided enables detect even weak breathing concept integrated system also presented system work directly digital circuits without converting electric signal presented system characterized simple construction offers new solution field sensor technology use operational amplifiers elsevier rights reserved
pterygoid process undergoes ossification cartilage membrane however studies attempted explore sequential development pterygoid process using histological examination performed morphological observations pterygoid process surrounding tissue icr mice embryonic days postnatal day used morphological observations pterygoid process embryonic day mesenchymal cell condensation forming anlage future medial pterygoid process differentiated osteoid like tissue cartilage embryonic days cartilage cells clearly evident medial pterygoid process medial pterygoid process bone collar evident calcified bone tissue surrounded cartilage point mesenchymal cell condensation formed anlage pterygoid hamulus embryonic days cartilages located along lower posterior border medial pterygoid process metachromatically stained matrix first became detectable around cells located pterygoid hamulus hand embryonic day metachromatically stained matrix already evident space flattened cells lateral pterygoid process embryonic day hypertrophic cell zone clearly formed diaphysis basis present investigation lateral pterygoid process classified primary cartilage whereas medial pterygoid process classified secondary cartilage furthermore found pterygoid hamulus formed latest medial pterygoid process
agility concept practice significant importance managing projects organizations although also risky due degree fuzziness properly defined research defines agility emphasizes need ontologies management creates application measure degree agility inside organization research various definitions agility gathered creation ontology mind map revealing characteristics agility part evolute theory methodology first agility ontology developed well application evaluates degree agility organization application includes statements respondents give opinions concerning current future desired states agility importance evaluative way application proven operate well extensive validation verification tests runs follow
previous research shown rating words relevance survival scenario leads better retention words rating self reference past studies however relied exclusively autobiographical self reference task participants rate easily common noun brings mind personal experience report five experiments comparing survival processing descriptive self reference task participants rated well trait words described rating trait adjectives survival value led higher levels recall recognition rating relevance moving home scenario rating adjectives self reference however led higher levels recall experiments recollection experiment survival rating experiment replaced trait adjectives trait nouns found self reference led greater recognition accuracy survival processing experiment used trait nouns followed tests free recall found memory advantage following self reference influenced imageability stimuli findings discussed terms theories survival processing self reference effects relationship elsevier inc rights reserved
various types long term stable relationships individuals uphold including cooperation competition group members define social complexity vertebrates numerous life history physiological cognitive traits shown affect affected social relationships differences developmental modes altricial precocial spectrum may play important role understanding interspecific variation occurrence social interactions extent case unclear role developmental mode studied directly across species studies sociality words although studies effects developmental mode brain size effects brain size cognition effects cognition social complexity studies directly investigating link developmental mode social complexity surprising developmental differences play significant role evolution example brain size turn considered essential building block respect social complexity compiled overview studies various aspects complexity social systems altricial precocial mammals birds although systematic studies scarce allow quantitative comparison show several forms social relationships cognitive abilities occur species along entire developmental spectrum based existing evidence seems differences developmental modes play minor role whether individuals species able meet cognitive capabilities requirements maintaining complex social relationships given scarcity comparative studies potential subtle differences however suggest future studies consider developmental differences determine whether finding general whether vast variation social complexity across species explained developmental mode would allow detailed assessment relative importance developmental mode evolution vertebrate social systems
background mhealth mobile health services becoming increasingly important form information communication technology ict enabled delivery healthcare especially low resource environments developing countries like bangladesh despite widespread adoption mobile phones acknowledged potential using improve healthcare services adoption acceptance technology among elderly significantly low however little research done draw systematic study elderly intention adopt mhealth services objective aim study develop theoretical model based unified theory acceptance use technology utaut empirically test determining key factors influencing elderly users intention adopt use mhealth services methods face face structured questionnaire survey method used collect data nearly participants age years capital city bangladesh data analyzed using partial least squares pls method statistical analysis technique based upon structural equation modeling sem results study determined performance expectancy effort expectancy social influence technology anxiety resistance change conclusions study confirms applicability utaut model context mhealth services among elderly developing countries like bangladesh provides valuable information mhealth service providers policy makers understanding adoption challenges issues also provides practical guidance successful implementation mhealth services additionally empirical findings identify implications related design development mhealth services influence potential users furthermore due generic approach findings study could easily modified assist developing countries planning take mhealth services elsevier rights reserved
research examines women sexual orientation guides accuracy judgements women one hundred ten judges straight lesbian women watched videotapes targets straight lesbian made judgements targets thoughts emotions personality sexual orientation accuracy scores created judge comparing judgements criterion data gathered targets straight judges significantly accurate judging thoughts marginally accurate judging emotions compared lesbian judges significant differences judging personality straight targets thoughts personality easily assessed lesbian targets lesbians emotions easily judged straight targets lesbian judges accurate judging sexual orientation regardless tendency categorize women lesbian compared straight judges findings support past research accurate perception sexual orientation contribute understanding sexual orientation guides person perception
duchenne muscular dystrophy dmd activated skeletal muscle infancy regardless underlying dystrophin mutation drives inflammation muscle degeneration inhibiting muscle regeneration edasalonexent cat bifunctional orally administered small molecule covalently links compounds known inhibit salicylic acid docosahexaenoic acid dha edasalonexent designed inhibit activated upon intracellular cleavage bioactive components preclinical data demonstrate disease modifying activity dmd animal models three placebo controlled studies adult subjects assessed safety pharmacokinetics pharmacodynamics single multiple edasalonexent doses seventy nine adult subjects received edasalonexent received placebo pharmacokinetic results consistent intracellular cleavage edasalonexent active components food increased plasma exposures edasalonexent salicyluric acid intracellularly formed metabolite salicylic acid pathway proteosome gene expression profiles peripheral mononuclear cells significantly decreased respectively weeks edasalonexent treatment activity inhibited following single dose edasalonexent equimolar doses salicylic acid dha edasalonexent well tolerated common adverse events mild diarrhea headache first human studies edasalonexent safe well tolerated inhibited activated pathways suggesting potential therapeutic utility dmd regardless causative dystrophin mutation well mediated diseases
background objective study determine influence loading frequency failure articular cartilage bone specimens three point bending methods study cyclic three point bending used introduce failure cartilage bone specimens varying loading frequencies sinusiodally varying maximum compressive loads range applied beam shaped cartilage bone specimens frequencies results number cycles failure decreased loading frequency increased normal gait impulsive loading frequencies found specimens reached run loading cycles frequencies respectively however specimens reached run loading frequencies conclusion results indicate increasing loading frequency reduces ability specimens resist fracture bending findings underline importance loading frequency concerning failure articular cartilage bone may implications early onset osteoarthritis
background objectives safety behavior detrimental beneficial effects exposure prevents patients obtaining evidence disconfirms excessive threat beliefs however previous studies showed cleaning exposure contaminant prevent reduction feelings contamination fear contamination danger disgust cfdd aimed directly examine effect exposure contaminant threat beliefs associated cfdd method healthy participants randomly assigned one three groups repeated exposure contaminant whilst abstaining exposure plus response prevention use disinfectant wipes instance exposure exposure plus exposure safety behavior control condition participants identified threat belief associated contaminant rated cfdd degree believed threat belief pre post test results condition resulted larger decrease cfdd threat belief ratings control condition whereas reductions differ condition limitations results obtained nonclinical sample single session exposure conclusion cleaning impede beneficial effects exposure elsevier ltd rights reserved
pulmonary exposure multi walled carbon nanotubes mwcnts may cause fibrosing lesions animal lungs raising health concerns exposure humans mechanisms underlying fibrosis development remain unclear believed involve dysfunction fibroblasts myofibroblasts using mouse model mwcnt exposure found tissue inhibitor metalloproteinase timp gene rapidly highly induced lungs mwcnts time dose dependent manner concomitantly pronounced elevation secreted timp observed bronchoalveolar lavage bal fluid serum knockout timp mice caused significant reduction fibrotic focus formation collagen fiber deposition recruitment fibroblasts differentiation fibroblasts myofibroblasts lungs indicating timp plays critical role pulmonary fibrotic response mwcnts molecular level mwcnt exposure significantly increased expression cell proliferation markers pcna panel cell cycle controlling genes lungs timp dependent manner mwcnt stimulated cell proliferation prominent fibroblasts myofibroblasts furthermore mwcnts elicited significant induction integrin lung fibroblasts leading formation timp integrin complex surface fibroblasts vivo vitro triggered phosphorylation activation erk study uncovers new pathway induced timp critically modulates pulmonary fibrotic response mwcnts promoting fibroblast activation proliferation via timp integrin axis erk signaling
flood protection methods affect erosion process dam breaking determines volume failure dam final profile article focuses experimental models different protection methods dam breaking flood overtopping experiments conducted rectangular tank erodible barrier dam made cohesive sand including five flood protection methods diversion trench side wall diversion trench middle wire box cement protection geotextile waterproof observe investigate erosion processes different water heads reservoir downstream dam time changing contribute various inner destructive mechanisms erosion processes three directions vertical horizontal backward resulted different erosion volumes initial dam breaking erosion process barrier dam related evacuation people downstream area final erosion volume bound coverage area flood well extent damage therefore concentrate analysis initial developmental process total erosion value results show wire box cement protection geotextile waterproof effectively retard growing larger volume flood diversion trench middle cause largest erosion volume dam body erosion processes determined interaction erosion abilities three directions also estimates presented retrogressive erosion velocity transverse broadening velocity vertical incision velocity
mobile edge computing enables deployment services applications content storage processing close proximity mobile end users highly distributed computing environment used provide ultra low latency precise positional awareness agile applications could significantly improve user experience order achieve necessary consider next generation paradigms information centric networking cloud computing integrated upcoming generation networking access cohesive end end architecture proposed fully exploiting information centric networking together mobile follow cloud approach enhancing migration content caches located edge cloudified mobile networks chosen content relocation algorithm attains content availability improvements mobile user performs request compared existing solutions performed evaluation considers realistic core network functional non functional measurements including deployment entire system computation allocation migration resources achieved results reveal proposed architecture beneficial users perspective also providers point view may able optimize resources reach significant bandwidth savings elsevier rights reserved
objectives validate italian version hypomanic personality scale hps non clinical sample young adults materials methods reliability convergent divergent validity discriminant capacity italian hps explored sample including undergraduate students attending italian university males convergent divergent validity tested association marlowe crowne social desirability scale sds short temperament evaluation memphis pisa paris san diego autoquestionnaire temps item general health questionnaire ghq peters delusions inventory pdi extended launay slade hallucination scale lshs discriminant capacity hps tested latent class analysis lca results reliability hps measured ordinal cronbach alpha differences distribution hps scores gender parental education proxy socio economic status age negatively related hps scores pearson scores hps negatively related social desirability expected hps related temps subscales measuring hypomania proneness temps subscales measuring proneness depression anxiety steigers test lower hps revealed stronger association measures delusion pdi hallucination proneness lshs generalist psychological distress ghq steigers test pdi psychometric threshold higher risk psychosis lca identified three classes sample compared baseline class participants people higher risk psychosis likely fall intermediate class greater odds high propensity hypomania class conclusions hps reveals good psychometric properties line studies cross cultural validity hps currently tested german spanish french samples hps suitable measure identify people hypomanic personality promising tool assist identification individuals higher risk bipolar disorder
frailty common associated poorer outcomes elderly role potential cardiovascular disease cvd risk factor requires clarification thus aimed meta analytically evaluate evidence frailty pre frailty risk factors cvd two reviewers selected studies comparing data cvd prevalence incidence rates frail pre frail robust association frailty status cvd cross sectional studies explored calculating pooling crude adjusted odds ratios ors confidence intervals cis data longitudinal studies pooled using adjusted hazard ratios hrs eighteen cohorts total participants meta analyzed using estimates cross sectional cohorts frailty pre frailty associated higher odds cvd robust participants longitudinal data obtained prospective cohort studies median follow years identified increased risk faster onset type cvd frail pre frail robust groups similar results apparent time cvd mortality frail pre frail groups conclusion frailty pre frailty constitute addressable independent risk factors cvd older adults elsevier rights reserved
primary myelofibrosis pmf myeloproliferative neoplasm classified according revision world health organization classification tumors haematopoietic lymphoid tissue ruxolitinib oral inhibitor janus kinase approved usa treatment intermediate high risk pmf approved europe treatment splenomegaly constitutional symptoms disease recently case reports described serious opportunistic infections neoplasm treated ruxolitinib research studies demonstrated immunological derangement compound mainly based dendritic natural killer cell defects purpose review literature analyze relationship among ruxolitinib immune system bacterial viral fungal protozoan infections literature search conducted using pubmed articles published january november efficacy drug patients pmf demonstrated two phase iii studies controlled myelofibrosis study oral jak inhibitor treatment comfort comfort grade neutropenia recognized patients ruxolitinib placebo arm comfort grade neutropenia leukopenia observed ruxolitinib treated patients year follow comfort addition leukocyte subpopulations lymphocyte functions antibody deficiency documented either studies complex interactions ruxolitinib bone marrow immune system infections pmf need investigation robust data randomized clinical trial registry large case series
multiphysics simulation technique based finite element method developed reliability analysis interconnects multiphysics simulation characterizes multidisciplinary including electrical thermal mechanical aspects interconnects well known major bottleneck preventing simulations gaining popularity computational efficiency dealing practically large scale problems address problem proposed multiphysics simulation devised analyzing large scale problems significantly improved computational efficiency utilizing domain decomposition scheme called finite element tearing interconnecting parallel computing localized nature thermal stresses interconnect structures capability efficiency multiphysics simulation demonstrated analyzing large scale interconnect structures including arrays solder bumps bonding wires detailed temperature distributions localized stresses large amplitude obtained proposed simulation highly efficient manner
paper presents local vector control lvc algorithm applicable power electronic systems controller differentiate linear non linear systems operate without change stationary rotating reference frames performance current controller particular emphasis current clamp minimisation paper focus comparison lvc predictive dead beat current controllers pcc presented
context partner services hiv sexually transmitted diseases public health intervention activity recommended centers disease control prevention includes counseling partner notification linkage care referral services objective time study partner services case investigations documented differences times process hiv sexually transmitted disease cases setting cases local regional sites new york participants fifty two partner services disease investigators documented randomly selected cases chlamydial infections gonorrhea hiv syphilis cases assigned june september cases unit analysis represented partner services investigations design cases selected via stratified random sampling infections assigned staff case disease investigators completed standard time study form document time spent specific tasks outcomes kruskal wallis tests continuous variables chi tests categorical variables assessed variation outcomes across infection type main outcome measures outcomes included minutes spent specific tasks medical provider index case outreach travel partner notification days case remained open disposition codes number partners reached results case processing times varied hiv syphilis tasks taking minutes cases staying open days partners notified cases overall notifications syphilis time median spent index cases median partner notification wide range across cases conclusions given chronic resource constraints public health agencies must identify efficient methods allocate resources including infections prioritize documenting workers allocate time across cases essential improving effectiveness efficiency program generating data model return investment
objective little information exists examines epidemiology injuries among adults engage sports recreational activities purpose study examine basketball related injuries among adults presenting ambulatory settings united states design retrospective review medical records setting emergency departments outpatient departments physicians offices united states patients nationally representative sample adults presenting ambulatory care settings united states treatment injuries incurred playing basketball main outcome measures body site injured type injury ambulatory treatment site utilization diagnostic testing results annual average adults treated ambulatory care setting injuries related playing basketball majority patients sought treatment physicians offices females much lower rate visits basketball related injuries males african american males rate times higher white males common injuries sprains strains lower leg ankle region fractures hand wrist fingers specific analyses patients presenting emergency department diagnosed sprain strain injuries lower leg ankle region revealed patients received ray procedure conclusions basketball injuries constitute significant portion ambulatory medical care use united states year particularly among young adult males african american males better surveillance adult participation sports recreational activities needed better identify risk protective factors injuries
clara haskil january december one famous female pianists century life work set new standards piano playing however career beset poor health adversities two world wars lifetime haskil three major disorders juvenile scoliosis requiring treatment adolescence tumor sellar region requiring surgery age years traumatic brain injury causing death age medical history illustrates development surgical methods rehabilitation medicine world war early age spent year nursing home orthopedic diseases due scoliosis years old displayed first symptoms suprasellar brain tumor headache hemianopsia famous surgeon marcel david performed surgery without general anesthesia haskil mentally played mozart piano concerto neuronal representation control memory mental abilities months operation played mozart piano concerto concert began career great interpreter mozart neurologic rehabilitation remarkable highlighted new methods field traveled brussels concert train station stumbled stairs hit head one steps skull fracture intracranial hematoma diagnosed doctors tried operate lost consciousness died haskil created new styles piano playing medical history offers indications new concepts neurosurgery
particles natural volcanic ashes photocatalyst configured packed bed photocatalytic reactor studied photodegradation wastewater pollutants solar light photocatalytic system equipped cylindrical parabolic sunlight concentrator photocatalytic treatment developed continuous flow wastewater sunlight irradiation influence incident radiation amount photocatalyst several configurations photoreactor hydrodynamics studied moreover results obtained compared obtained photolysis adsorption studies good photocatalytic activities observed allows concluding heterogeneous photocatalytic system packed bed effective method wastewater pollutants removal sunny day contaminant removed continuous flow photocatalytic treatment wastewater packed bed reactor sunlight possibility combining renewable energy solar energy photocatalytic technology means sustainable photocatalytic material offers powerful alternative wastewater treatment sector
rationale social cognition influences social interactions alcohol reportedly facilitates social interactions however acute effects alcohol social cognition relatively poorly studied investigated effects alcoholic non alcoholic beer emotion recognition empathy sexual arousal using dynamic face emotion recognition task fert multifaceted empathy test met sexual arousal task sat double blind random order cross study healthy social drinkers also assessed subjective effects using visual analog scales vass blood alcohol concentrations plasma oxytocin levels alcohol increased vas ratings stimulated happy talkative open want others subjective effects alcohol greater participants higher trait inhibitedness alcohol facilitated recognition happy faces fert enhanced emotional empathy positive stimuli met particularly participants low trait empathy pictures explicit sexual content rated less pleasant neutral pictures non alcoholic beer alcoholic beer explicit sexual pictures rated pleasant alcoholic beer compared non alcoholic beer particularly women alcohol alter levels circulating oxytocin alcohol biased emotion recognition toward better decoding positive emotions increased emotional concern positive stimuli support found modulatory role oxytocin alcohol also facilitated viewing sexual images consistent disinhibition actually enhance sexual arousal effects alcohol social cognition likely enhance sociability www clinicaltrials gov show nct reftarget address http www clinicaltrials gov show nct targettype url
purpose know little transgender people create families issues involved decisions qualitative study explored parenting intentions desires self identified transgender individuals want become parents future methods data collected using open ended survey transgender men transgender women regarding want become parents future results found transgender individuals expressed specific desires parenthood biological relatedness barriers parenthood physical limitations lack legal protections influence transgender individuals choose become parents future example many participants described wanting biologically related future child complicated transgender due hormonal treatments surgeries biological means become parent using traditional methods conclusions barriers desires discussed provide invaluable insight parenting intentions reproductive health transgender people study revealed numerous examples healthcare professionals could benefit new knowledge increasing communication patients desires issues related treatment reproduction
sponsored new york academy sciences cincinnati children hospital medical center support national institute environmental health sciences niehs national institute drug abuse nida life technologies fetal programming environmental exposures implications prenatal care preterm birth held june new york academy sciences new york city meeting comprising individual talks panel discussions highlighted basic clinical translational research approaches highlighted need specialized testing drugs consumer products industrial chemicals view unique impacts gestation speakers went discuss many factors affect prenatal development genetics parental diet revealing extraordinary sensitivity developing fetus
background purpose study evaluate mid term results oxford phase unicompartmental knee arthroplasty uka medial arthritis chinese patients methods study included patients underwent minimally invasive oxford phase uka medial knee arthritis patients clinically evaluated preoperatively final follow according clinical functional components knee society score kss hospital special surgery knee score range motion kaplan meier survivorship analysis performed revision surgery end point results mean preoperative clinical ksss increased post operatively mean functional ksss increased post operatively addition mean hospital special surgery scores increased mean active knee flexion increased degrees preoperatively degrees post operatively total six patients six knees required revision surgery time maximum year follow four conversions total knee arthroplasty performed arthritis progression lateral compartment one revision total knee arthroplasty performed aseptic loosening one liner exchange performed wear cumulative survival rates year follow ups respectively conclusion oxford phase uka largely applicable medial arthritis chinese patients however oxford phase medial uka selection criteria young chinese males need exploration obtain best treatment effect
software defined networking sdn supports flexibly routing switching splitting control plane data plane network devices however security resource utilization sdn inefficient especially process routing path construction paper present novel model sdn controller construct secure routing paths based network security virtualization nsv latest network status new scheme considers various security devices functionalities trust different network devices routing path establishment also introduce identity based authentication module ensure legitimacy routing policies sdn implement prototype system nsv guard conduct theoretical analysis performance evaluation results demonstrate approach optimally utilize existing security devices mechanisms sdn addition nsv guard efficiently verify malicious fake routing policies generated unregistered routing applications
article devoted consideration art communicative system example syncretic forms song dance gypsy culture reviewing historical cultural interactions gypsies european peoples analyzing original forms gypsy art author examines levels results intercultural dialogue
objectives patients ankylosing spondylitis elevated risk development coronary artery disease risk cerebrovascular disease among patients remains incompletely understood investigated cerebrovascular risk profiles patients cerebrovascular disease compared profiles cerebrovascular disease patients without methods retrospectively analysed patients ischemic cerebrovascular disease also diagnosed controls without respect patient age gender cerebrovascular risk factors laboratory test results results patients significantly younger control patients study years years respectively logistic regression analysis indicate significant relationships gender cerebrovascular risk factors biochemical risk factors patients significant relationships found erythrocyte sedimentation rate reactive protein biochemical risk factors low frequency large artery atherosclerosis high frequency small vessel occlusion according trial org acute stroke treatment toast classification found patients stroke conclusions among population included study patients sought treatment cerebrovascular disease younger age compared control patients without thus results indicate patients increased risk premature onset cerebrovascular disease premature atherosclerosis may associate patients furthermore high frequency small vessel stroke subtype patients indicates small vessel inflammation may involved pathogenesis vascular diseases patients prospective study samples needed confirm hypothesis
health care services show epidemiological changes increase number consultations due mental causes violence without necessary capacity respond increasing demand objective analyze compare demand hospitalization due psychosocial causes pediatric hospital three different periods materials methods descriptive retrospective study cases children adolescents hospitalized psychosocial causes hospital ninos santisima trinidad cordoba data processed using frequency analysis chi square test results records analyzed hospitalization rate year hospitalization rate psychosocial causes increased years common reasons admission suspected child abuse suicidal behavior suspected sexual abuse substance abuse psychomotor agitation episode psychotic episode showed prevalence psychomotor agitation episode psychotic episode suicidal behavior suspected sexual abuse common women psychomotor agitation episode substance abuse common men conclusions hospitalizations psychosocial causes particularly mental causes children adolescents increased show different behavior according age gender health problems related violence frequent ones
interest systematic study circadian typology relatively recent developed rapidly two last decades existing data suggest individual difference affects biological psychological functioning health also disease present study review current literature concerning psychometric properties validity measures well individual environmental genetic factors influence present brief overview biological markers used define differences groups sleep wake cycle body temperature cortisol melatonin assess implications adjustment shiftwork jet lag also review differences terms cognitive abilities personality traits incidence psychiatric disorders necessary emphasized methodological limitations exist today suggested future avenues work order overcome new field interest professionals many different areas research labor academic clinical review provides state art discussion allow professionals integrate chronobiological aspects human behavior daily practice
open loop unstable systems time delays often encountered process industry often difficult control stable processes paper stabilization pid controller second order unstable processes represented second order deadtime unstable pole sodup second order deadtime two unstable poles sodtup performed via necessary sufficient criteria routh hurwitz stability analysis stability analysis provides improved understanding existence stabilizing range pid parameter three simple pid tuning algorithms proposed provide desired closed loop performance robustness within stable regions controller parameters obtained via stability analysis proposed pid controllers show improved performance derived via existing methods published elsevier ltd behalf isa
present newly fully automated data pipeline solvepol designed reduce analyze polarimetric data optimized imaging data instituto astronomia geofisica cap ncias atmosfericas iag university tildeo paulo usp calcite savart prism plate based iagpol polarimeter solvepol also basis reduction pipeline wide field optical polarimeter execute south pol survey polarized southern sky solvepol written using interactive data language idl based image reduction analysis facility iraf task pccdpack developed polarimetry group present discuss reduced data standard stars fields compare results obtained iraf environment analysis shows solvepol addition fully automated pipeline produces results consistent reduced pccdpack reported literature
thought disorder pernicious nonspecific aspect numerous serious mental illnesses smis related conditions despite decades empirical research thought disorder present understanding poor clinical assessments focus limited set extreme behaviors treatments palliative best applying research domain criteria rdoc framework thought disorder research offers advantages explicate phenotype isolate mechanisms develop effective assessments treatments potential cures commentary discuss ways thought disorder understood within rdoc framework propose operationalizing thought disorder within rdoc construct language using psycholinguistic sciences help objectify quantify language within individuals technologically sophisticated paradigms allow naturalistic behavioral sampling techniques unprecedented ecological validity computational modeling account network interconnected dynamic linguistic cognitive affective social functions also highlight challenges understanding thought disorder within rdoc framework thought disorder likely occur isomorphic dysfunction single rdoc construct rather multiple potential dysfunctions network rdoc constructs moreover thought disorder dynamic time context within individuals sum rdoc useful framework integrate multidisciplinary research efforts aimed operationalizing understanding ameliorating thought disorder
causal attributions mental health problems play crucial role shaping differentiating illness experience different sociocultural ethnic groups aims study analyze older somali refugees causal attributions mental health problems examine associations demographic diagnostic characteristics proxy indicators acculturation causal attributions analyze connections causal attributions manifestation somatic affective cognitive depressive symptoms sample somali refugees aged years living finland asked list top three causes mental health problems depressive symptoms analyzed using beck depression inventory bdi results showed commonly endorsed causal attributions mental health problems jinn jealousy related polygamous relationships various life problems identified five attribution categories somatic interpersonal psychological life experiences religious causes common causal attribution categories life experiences interpersonal causes mental health problems men tended attribute mental health problems somatic psychological causes women interpersonal religious causes age proxy indicators acculturation associated causal attributions participants psychiatric diagnosis treatment history reported somatic psychological attributions participants finally attributed mental health problems life experiences war reported marginally fewer cognitive depressive symptoms guilt results discussed relation biomedical models mental health service use immigration experiences culturally relevant patterns symptom manifestation
heterostructured nanocomposites offer promise creating systems exhibiting functional properties exceed isolated components solar energy conversion combinations semiconducting nanomaterials used direct charge transfer along pathways reduce recombination promote efficient charge extraction however interfacial energetics associated kinetic pathways often differ significantly predictions derived characteristics pure component materials particularly nanoscale emergent properties tio bivo nanocomposite photoanodes explored using combination ray optical spectroscopies together photoelectrochemical pec characterization application methods pure components fully assembled nanocomposites reveals unpredicted interfacial energetic alignment promotes ultrafast injection electrons bivo tio physical charge separation yields extremely long lived photoexcited states correspondingly enhanced photoelectrochemical functionality work highlights importance probing emergent interfacial energetic alignment kinetic processes understanding mechanisms solar energy conversion complex nanocomposites
novel closed loop process demonstrated control deposition microstructure laser additive manufacturing lam real time infrared imaging system developed monitor surface temperatures process feedback signals cooling rates melt pool temperatures recorded real time provide adequate information regarding thermal gradients thus control deposition microstructure affected cooling rates lam using correlations cooling rate traveling speed clad microstructure novel feedback pid controller established control cooling rate controller designed maintain cooling rate around desired point tuning traveling speed performance controller examined several single track multi track closed loop claddings order achieve desired microstructures specific properties results indicate closed loop controller capable generating consistent controlled microstructure lam process real time
management airway may challenging patients undergoing occipito cervical spine fusions ocf changes occipito cervical angle doca fusion surgery may result acute airway obstruction dyspnea dysphagia objectives study review airway management patients posterior ocf determine incidence nature risk factors postoperative airway adverse events aes determine relationship airway aes change doca retrospective cohort patients following extubation operating room complications patients group sixteen patients group airway complications requiring reintubation delayed extubation number vertebral levels fused presence difficult intubation duration surgery significantly associated aes significant difference doca groups versus airway management patients undergoing ocf poses challenge anesthesiology surgical teams incidence aes decision extubate immediately surgery needs individualized factors difficult intubation number vertebral levels fused duration surgery considered significant correlation doca postoperative aes could established risk factors postoperative aes multifactorial prospective evaluation factors indicated elsevier ltd rights reserved
compare thermodynamics catalysis two important exothermic chemical reactions homogeneously catalyzed chain reaction oxidation heterogeneously catalyzed ammonia synthesis important exothermic physical reaction namely proton neutron synthesis elementary particles quarks relativistic neutrinos process known hadronization show surprisingly hadronization several similarities homogeneous autocatalytic chain reactions well heterogeneously catalyzed ammonia synthesis synthesis presence electrical charge namely alkali promoters protons electrons transition metals enhances formation catalytically active intermediate species hadronization free electrons positrons lower activation energy facilitate formation catalytically active bosonic neutrino intermediates entities liberate highly active neutrinos creating via relativistic mass increase strong local gravitational field mass producing properties higgs field main analogies differences electric field effects chemical catalysis electric gravitational field effects hadronization catalysis identified briefly discussed elsevier rights reserved
three dimensional thermal resistance analysis provides rapid simple method estimate power generated waste heat recovery system thermoelectric generators tegs facilitates optimization system system comprises three parts waste heat recovery chamber teg modules cooling system fin structured duct serves waste heat recovery chamber attached hot sides tegs cold sides tegs attached cooling system waste heat recovery chamber harvests energy exhaust heat tegs convert electricity estimation generated power important part system design methods computational fluid dynamics cfd assist analysis improve performance great accuracy great computational duration use method saves much time relative cfd methods thermal resistance analysis node unknown temperature located centroid cell system divided relations unknown temperatures cells based energy conservation definition thermal resistance temperatures inlet waste hot gas ambient fluid known boundary conditions unknown temperatures system solved enabling estimation power generated tegs model system simulated flotherm numerical solution matched solution thermal resistance analysis within power generated system tegs tmh wise life technology taiwan measured experimental result consistent result obtained thermal resistance analysis relative deviation approximately power generated affected many variables positions tegs uniformity internal flow velocity profile internal external flow velocities considered thermal resistance analysis according results positions tegs uniformity internal flow velocity profile taken account maximize power generation varied operational conditions power generated system might sensitive velocity either internal external flow choosing appropriate method makes increasing power generation efficient relations variables power generation readily revealed even varied parameters yielding optimal design waste heat recovery system elsevier ltd rights reserved
due high availability data users frequently overloaded huge amount alternatives need choose particular item motivated increased interest research recommendation systems filter options provide users suggestions specific elements movies restaurants hotels books etc estimated potentially relevant user paper describe evaluate two possible solutions problem identification type item music movie book etc user specifies pull based recommendation recommendation certain types items explicitly requested user evaluate two alternative solutions one based use hidden markov model another one exploiting information retrieval techniques comparing proposals experimentally observe hidden markov model performs generally better information retrieval technique preliminary experimental setup
research suggests humans attentional bias rapid detection emotionally valenced stimuli bias might shaped clinical psychological states current research extends work examine relation body dissatisfaction attentional bias thin idealized body shapes across two experiments undergraduates completed gender consistent body dissatisfaction measure dot probe paradigm measure attentional biases thin versus heavy bodies results indicated men women show attentional bias bodies correspond gender experiment high body dissatisfaction among men women predicts attentional bias thin gender bodies controlling body mass index bmi experiment research provides new direction studying attentional cognitive underpinnings relation body dissatisfaction eating disorders elsevier ltd rights reserved
introduction care individuals alzheimer disease related dementias adrd poses special challenges disease progresses individuals adrd require increasing levels medical care caregiver support long term care lead substantial economic burden areas covered expert review synthesized findings studies costs adrd united states published january february highlighted major sources variation costs identified knowledge gaps briefly outlined directions future research implications policy program planning expert commentary consistent finding studies comparing individuals without adrd average medical non medical indirect costs individuals adrd higher without adrd despite differences methods identifying adrd duration study payer type settings study population economic burden adrd may underestimated many components direct non medical costs home safety modifications adult day care services indirect costs due adverse impact adrd caregivers health productivity included cost estimates
non salient permanent magnet machines considered poor candidates flux weakening operations due inherent low inductance characteristics paper two pole slot non salient machine design proposed utilize winding switching technique achieve wide speed range operation wide speed range operation ratio much demonstrated accomplished simply rearranging winding coils stator periphery moreover control strategy proposed utilizes flux weakening using winding switching also flux weakening using negative axis current maximize speed range machine machine operated two inverters control current machine winding entire speed range model machine also presented analytical simulated experimental results provided validate proposed machine drive system
introduction self medication especially analgesics common practice among undergraduate medical students variation analgesic self medication prevalence pattern often seen due geographical target population differences mutual influence pain sleep quality might persuade students self medication behaviour aim assess analgesic self medication association sleep quality among medical undergraduates materials methods cross sectional questionnaire based study conducted december february among medical undergraduates information socio demographic profile symptoms types analgesics source information reason analgesic self medication collected sleep quality students assessed pittsburgh sleep quality index psqi qualitative variables expressed percentages odds ratio confidence interval also calculated chi square test used results analgesic self medication prevalence prevalence seen among males seniors urban residents students working parents headache common cause paracetamol frequent drug used based knowledge obtained textbook internet mildness symptoms important motivation behind self medication analgesic use among poor sleepers compared normal sleepers conclusion despite easy accessibility expert consultations high prevalence analgesic self medication among medical students association poor sleep quality distressing issue indicates urgent need awareness programmes harmful effects self medication healthy sleep practices
introduction optimal vitamin status promotes skeletal health recommended specific treatment individuals high risk fragility fractures growing body literature provided indirect direct evidence possible extraskeletal vitamin related effects purpose methods members european society clinical economic aspects osteoporosis osteoarthritis reviewed main evidence possible proven benefits vitamin supplementation adults risk overt chronic extra skeletal diseases providing recommendations guidelines future studies field results conclusions robust mechanistic evidence available vitro studies vivo animal studies usually employing cholecalciferol calcidiol calcitriol pharmacologic rather physiologic doses although many cross sectional prospective association studies humans shown low hydroxyvitamin levels nmol simultaneously assess multiple outcomes report overall safety falls thus recommendations made date use vitamin supplementation general parental compounds non hypercalcemic vitamin analogs prevention treatment extra skeletal chronic diseases moreover attainment serum hydroxyvitamin levels well threshold desired bone health recommended based current evidence since safety yet confirmed finally promising findings mechanistic studies large cohort studies small clinical trials obtained autoimmune diseases including type diabetes multiple sclerosis systemic lupus erythematosus cardiovascular disorders overall reduction mortality require confirmation
chitosan family glucosamine acetyl glucosamine polysaccharides poorly understood immune modulating properties functional macrophage responses analyzed response novel library twenty chitosans controlled degree deacetylation dda molecular weight kda acetylation pattern block random specific chitosan preparations kda block dda kda dda either induced macrophages release cxcl ira activated inflammasome release beta pge chitosan induction factors required lysosomal acidification cxcl production preceded lysosomal rupture shown time dependent localization galectin chitosan slowed autophagy flux specifically depended ifn beta paracrine activity stat activation could suppressed pge chitosan induced type ifn paracrine response inflammasome response depending extent lysosomal rupture cytosolic foreign body invasion study identifies structural motifs lead chitosan driven cytokine responses macrophages indicates lysosomal rupture key mechanism determines endogenous release either beta authors published elsevier ltd
technological innovations ubiquitous computing augmented reality telecommunication intelligent appliances robotics bring new possibilities smart home domain led increase number academic publications domain date comprehensive overview clustering core concepts used publications produced based extensive review existing literature smart home paper visualizes state art smart home research systematic way outlines future research challenges business model framework applied helps researchers place work within broader context identify gaps existing body knowledge area order move exploration towards exploitation smart home concepts essential contribute coherent body knowledge technology driven case also pay attention non technological aspects social organizational economical organizational law legislation entrepreneurial topics strategic operational perspective
since passage title female sports participation dramatically increased benefits physical activity including decreased risk heart disease diabetes well improved body image self esteem far outweigh risks however select population adolescent young adult females may experience symptoms related female athlete triad triad refers interrelatedness energy availability menstrual function bone mineral density bmd conditions often manifest clinically disordered eating behaviors menstrual irregularity stress fractures individual may suffer triad components simultaneously complex nature triad treatment challenging requires multidisciplinary approach team members often include physician psychologist psychiatrist nutritionist dietitian physical therapist athletic trainer coach family members importantly patient thorough physical examination primary care physician essential identify organs systems may impacted triad related conditions laboratory tests assessment bone density nutritional assessment behavior health evaluation guide management female athlete triad related conditions treatment triad includes adequate caloric consumption restore positive energy balance often first step successful management triad addition determining cause menstrual dysfunction resumption menses important nonpharmacologic interventions first choice pharmacologic treatment reserved patients symptoms estrogen deficiency infertility lastly adequate intake calcium vitamin critical lifelong bone health review comprehensive search relevant databases earliest dates july performed keywords including female athlete triad adolescent female athlete disordered eating eating disorder low energy availability relative energy deficit anorexia bulimia menstrual dysfunction amenorrhea oligoamenorrhea bone mineral density osteopenia osteoporosis stress fracture stress reaction utilized search relevant articles articles directly addressed assessment management triad components included comprehensive review purpose narrative review provide reader latest terms used define components female athlete triad discuss examination diagnosis triad lastly provide reader latest evidence successfully implement multidisciplinary treatment approach providing care adolescent female athlete may suffering triad related components
imaging spectrometers second orbiting carbon observatory radiometrically calibrated launch instrumentlevel ground testing gain dark responses characterized focal plane array detector element integrating sphere source integrated monitoring spectroradiometer illuminated oco spectrometers many light levels instrument output compared calibrated output source derive gain coefficients source calibrated situ respect national institute standards technology reference standards instrument met absolute performance requirement matching fields view internal monitor detectors external instrument test found particularly important observed results supported modeling temperature dependent dark offsets corrected separate process solar spectra varying neutral density filters used validate linearity spectrometers
interleukin suspected associated response treatment one basic immunological backgrounds liver transplant candidate ltc aimed assess whether genotypes play role therapeutic response advanced stages liver disease total subjects genotyped snps using pcr rflp assay moreover serum level hcv loads genotype performed significant increase observed frequencies unfavorable genotypes chronic hepatitis chc ltc groups case chc group significantly higher frequency unfavorable genotypes compared healthy group serum level also significantly higher healthy group compared chc ltc groups differences distribution genotypes haplotypes responder non responder patients results suggest first time unfavorable genotypes considered one important immunological backgrounds iranian ltc population confirmed lower serum level compared healthy group besides possible association favorable genotypes lower odds susceptibility chc infection support positive association analyzed snps outcome therapy moreover non haplotypes may regarded genetic risk factor increase chance infection hcv progression toward end stage hcv related liver disease
solving large scale sparse linear systems plays key role fluid mechanics simulation design materials petroleum seismic data processing numerical weather prediction computational electromagnetics numerical simulation unclear explosions therefore developing algorithms issue significant research topic paper proposed hyper scale custom supercomputer architecture matches specific data features process key procedure block wiedemann algorithm parallel algorithm custom machine increase computation communication storage performance four optimization strategies proposed paper builds performance model evaluate execution performance power consumption custom machine model shows optimization strategies result considerable speedup even three times faster fastest supercomputer consuming less power
schizophrenia associated heightened stress responsivity adolescence precedes onset psychosis report multiple stressors adolescence normal rats leads deficits adults analogous seen schizophrenia patients moreover impairment stress control lesion prelimbic prefontal cortex adolescence caused previously subthreshold levels stress induce deficit states tested adults thus predisposition stress hyper responsivity exposure substantial stressors adolescence trigger cascade events result schizophrenia like profile adults data provide crucial information respect identifying markers schizophrenia vulnerability early life mitigating impact stressors prevent transition psychosis
huge quantities water wasted daily basis worldwide leakages water transporting infrastructures causing water shortage injuries problem typically worsened lack advanced monitoring systems respect wireless sensor networks wsns revolutionised water monitoring systems providing reliable inspection feasible communication performing applications study presents comprehensive survey software hardware solutions proposed literature water pipeline infrastructure monitoring fact several leak detection localisation techniques like acoustic ultrasound pressure ones studied evaluated several research works tried implement techniques using different types wsn platforms including microcontroller digital signal processor application specific integrated circuit field programmable gate array platforms reviewed discussed highlighting advantages drawbacks finally integrated energy aware system chip solution using high performance hardware proposed achieve optimal reliable results
study question ulipristal acetate upa mifepristone effect ciliary beat frequency muscular contractions human fallopian tube summary answer upa resemblance mifepristone inhibits ciliary beat muscular contraction human fallopian tube probably agonistic effect tubal progesterone receptor known already upa like mifepristone acts emergency contraceptive mainly inhibiting ovulation little known effects tubal function study design size duration vitro experimental study using fallopian tube samples collected women undergoing hysterectomy benign non tubal gynaecological conditions participants materials setting methods tubal epithelium longitudinal smooth muscle fibres isolated cultured treated upa graded concentrations mifepristone graded concentrations respectively treatment ciliary beat frequency determined using photometric method basal tone amplitude frequency muscular contraction recorded force transducer mrna expression progesterone receptor total isoform glycodelin adrenomedullin determined real time quantitative pcr main results role chance overall dose dependent suppressive effect ciliary beat frequency treatment upa concentrations mifepristone basal tone amplitude frequency muscular contractions significantly reduced treatment upa mifepristone upa treatment significantly regulated mrna expression progesterone receptor glycodelin regulated mrna expression adrenomedullin fallopian tube tissue limitations reasons caution whether tubal effect may translate additional mechanisms contraceptive action vivo uncertain wider implications findings clinical relevance upa regard contraceptive activity worthy exploration study funding competing interest study supported seed fund centre reproduction development growth faculty medicine university hong kong authors competing interest declare
modern digital conununications favor ofdm systems advantages spectral efficiency reduced inter symbol interference isi flexibility deployment across various frequency bands little modification air interface one principle challenges ofdm systems cost complexity system implementation recent developments field digital electronics software defined radio opened various possibilities simplified solutions complexities field programmable gate arrays fpga provide perfect platform purpose low cost easy programmability vast resources work presents simplified design fpga implementation ofdm system specified european telecommunications standard institute etsi satellite digital radio etsi using xilinx dsp design tools
paper based prospective scenario development rainwater harvesting rwh given large urban area metropolitan area region perspective new method proposed quantify related potential potable water savings ppws indicator type area adapting reference model usually used building level method based four setting principles gathering definition buildings types municipalities types progressing use intermediate level increasing choice upper estimation prioritizing ranking stakes rwh application paris agglomeration shows possible save total current potable water use rwh also shows residential sector offers important part holds two thirds agglomeration ppws
functional factors responsible fluoride bearing groundwater used drinking well cooking area gummanampadu sub basin guntur district andhra pradesh india discussed study area part archean gneissic complex consisting banded biotite hornblende gneisses proterozoic cumbhum quartzites shales phyllites dolomitic limestones occur chemistry groundwater dominated carbonates hco higher results higher total alkalinity total hardness causing excess alkalinity sodium ion dominated among cations concentration higher desirable national limit prescribed drinking purpose significant positive correlation exists well hco indicates alkaline condition prime conducive factor dissolving bearing minerals effectively leading higher concentration groundwater furthermore positive chloro alkaline index reflects ion exchange oversaturation respect caco indicates evaporation addition negative relation well depth shows effect solubility leaching salts different depth levels factors regulate concentration groundwater hand positive correlation well shows human land use activities namely use chemical fertilizers disposal domestic wastes etc add groundwater significant number residents study area suffer health disorders related fluorosis consequence higher concentration drinking water thus study emphasizes need supply safe drinking water nutritional diet rainwater harvesting structures public education realize health motto world health organization
variation among existing studies labeling defining identifying subtyping cases suspected drug facilitated sexual assault dfsa poses challenges integrating research findings public health purposes descriptive study addressed methodological issues nomenclature dfsa operational definitions improve case identification designed distinguish assault subtypes studied year ethnically diverse cohort patients presented acutely urban rape treatment center rtc abstracted data rtc medical mental health records via chart review assault incidence rates engagement medical forensic mental health services injury sustained weapon use calculated separately assault subtypes compared dfsa accounted half total sexual assault cases involuntary dfsa incapacitating substance administered victims without knowledge increased cases year period dfsa victims presented sooner often attended medical follow psychotherapy non dfsa victims incidence rates indicated increasing risk young males findings indicate dfsa continues growing complex phenomenon suggest dfsa victims greater service needs field would benefit innovations address symptomatology arising novel type trauma unique risks needs male victims well underscoring ongoing need dfsa specific prevention efforts victims perpetrators
current applications complex sensor systems quantified self online markets acquire vast quantities personal information usually end central servers exposed prying eyes conversely decentralized architectures help individuals keep full control data complexify global treatments queries impeding development innovative services article aims precisely reconciling individual privacy one side global benefits community business perspectives promotes idea pushing security secure hardware devices controlling data place acquisition thanks tangible physical elements trust secure distributed querying protocols reestablish capacity perform global computations structured query language sql aggregates without revealing sensitive information central servers article studies secure execution queries presence honest curious malicious attackers also discusses resulting querying protocols integrated concrete decentralized architecture cost models experiments sql asymmetric architecture distributed prototype running real tamper resistant hardware demonstrate approach scale nationwide applications
clergy members suffering burnout face personal professional complications study assessed occupational burnout stress coping mechanisms among ministers affiliated assemblies god denomination received little attention previous burnout related studies cross sectional design employed using two instruments acceptable psychometric properties approximately surveyed either suffering burnout verge burnout statistical differences coping mechanism use found experiencing level burnout results study add existing understanding occupational burnout among clergy members ways burnout may alleviated
paper concerned constructing nodal radial solutions generalized quasilinear schrodinger equations critical growth arise plasma physics fluid mechanics well self channeling high power ultashort laser matter find critical exponents generalized quasilinear schrodinger equations obtain existence sign changing solution nodes given integer
anatase tio widely used support supported vanadium based non vanadium based catalysts scr reaction however lack enough attention brookite rutile tio therefore present work synthesize series tio tio tio used supports prepare ceo tio ceo tio ceo tio catalysts purpose clarifying crystal form effect tio supports physicochemical properties catalytic performance supported ceria based catalysts scr reaction characterization results exhibit consumption responding reduction property acid amounts surface content surface adsorbed oxygen species catalytic performance supported ceria based catalysts give order ceo tio ceo tio ceo tio related interaction ceo tio anatase brookite rutile especially ceo catalyst exhibits optimal catalytic performance scr reaction among supported ceria based catalysts owing excellent reduction property well largest amounts acid sites surface content surface adsorbed oxygen species elsevier rights reserved
cystic fibrosis chronic pulmonary disease associated persistent microbial infection chronic neutrophil infiltration also elevated production pro inflammatory cytokine current study examined inducible receptor subunit neutrophils pseudomonas aeruginosa infected fdel patients time pulmonary exacerbation following intravenous antibiotic treatment neutrophils expressed ila ilrc transcripts protein time pulmonary exacerbation absent following antibiotic treatment sputum induced dependent ilrc expression neutrophils healthy individuals similarly producing neutrophils detected fdel cftr mice infected intranasally aeruginosa sputum subjects percentage producing neutrophils correlated elastase mmp activity therefore population neutrophils may important contributor severity pulmonary disease patients elsevier inc rights reserved
aim danish national chronic myeloid neoplasia registry dcmr population based clinical quality database introduced evaluate diagnosis treatment patients chronic myeloid malignancies aim monitor clinical quality national regional hospital departmental levels serve platform research study population dcmr nationwide coverage contains information patients diagnosed hematology departments january onward including patients essential thrombocythemia polycythemia vera myelofibrosis unclassifiable myeloproliferative neoplasms chronic myelomonocytic leukemia chronic myeloid leukemia main variables data collected using standardized registration forms far four forms per patient consecutively filled online time diagnosis year year follow ups end follow forms include variables describe clinical paraclinical assessments treatment disease progression survival disease specific variables well variables identical chronic myeloid malignancies descriptive data end dcmr contained data patients inclusion rate similar patients year since registry established annual reports shown consistently high national coverage data completeness respectively conclusion dcmr national database used monitoring quality patient care patients chronic myeloid malignancies validation conducted data must used caution however dcmr valuable data source accessible clinicians researchers
common way learn studying written step step tutorials worked examples however tutorials computer programming tedious create since static text based format convey happens code executes created system called codepourri enables people easily create visual coding tutorials annotating steps automatically generated program visualization using codepourri developed novel crowdsourcing workflow learners visiting educational website www pythontutor com collectively create tutorial annotating execution steps piece code voting best annotations since far learners experts using learners crowd potentially scalable way creating tutorials experiments expert judges learners adding raw annotations two pieces textbook python code show learner crowd annotations accurate informative containing insights even experts missed
timely implementation construction works scheduled time vital investor contractor yet construction projects even perfectly planned organized run risk delays despite many tools supporting construction management delays keep occurring construction projects present paper presents findings survey aimed identifying important causes delays construction works client perspective factor analysis performed allow interpret dependencies knowledge helpful minimizing risk delays published elsevier ltd
one factor seems influence individual effectiveness requirements engineering activities knowledge problem solved domain knowledge depth domain knowledge enables requirements analyst understand problem easier fall tacit assumptions fail consider issues believes obvious paper investigates impact domain knowledge requirements engineering activities main research question one form effective team consisting mix domain ignorants domain awares requirements engineering activity involving knowledge domain computer based system whose requirements determined team completeness number factors educational background considered effect teams effectiveness two controlled experiments test number hypotheses derived question including mainly computer based system particular domain team consisting mix requirements analysts ignorant aware domain effective requirement idea generation team consisting analysts aware domain results show significant effect mix effectiveness requirement idea generation however results show surprising significant effects educational background mix combined educational background combining results main conclusion presence domain ignorant computer science software engineering background improves effectiveness requirement idea generation team
unavailability site specific allometric equations estimate forest biomass promoted use general equations tropical moist forests may result errors estimates aim study develop site specific allometric equations estimate biomass trees tropical moist forests cameroon study trees obtained destructive method used develop allometric equations estimation aboveground biomass allometric equations estimate belowground total biomasses developed trees trees respectively trunk crown biomass estimators also developed study using sample trees predictor variables considered diameter tree height wood density crown diameter trees also used develop regressions equations estimate tree height crown diameter respectively remote sensing applications study developed allometric equations estimate aboveground biomass using crown diameter predictor variable comparison biomass data existing models showed equation djomo provided best estimator total mean biomass study contributes site specific allometric equations knowledge belowground trunk crown total biomass lack biomass data tropical moist forests also adding allometric equations application remote sensing study significant input implementation redd central africa elsevier rights reserved
data become important asset many organizations companies individuals thus security relational databases encapsulate data become major concern standard database security mechanisms well network based host based intrusion detection systems rendered inept detecting malicious attacks directed specifically databases therefore imminent need developing intrusion detection system ids specifically database paper propose use random forest algorithm anomaly detection core mechanism conjunction principal components analysis pca task dimension reduction experiments show pca produces compact meaningful set features graphical method likely exploit inherent tree structure characteristic sql queries exhibits consistently good performance terms false positive rate false negative rate time complexity even varying number features
teenage birth rates among young people aged years california usa declined births per per nevertheless counties highest teenage birth rates predominantly rural high proportion latinos conducted interviews key stakeholders focus groups young people five rural communities better understand local migration patterns influence intermediate proximate variables pregnancy interaction role models barriers access contraception migration patterns identified residential mobility due seasonal jobs residential mobility due economic housing changes migration countries california patterns affect young people families interactions school health systems community members creating opportunities barriers prevent risky sexual behaviours rural areas residential mobility migration usa interconnect result young people dually navigate challenges residential mobility also adapting dominant culture important promote programmes support integration immigrant youth reduce sense isolation well assure access sexual health education reproductive health services
wind speed forecasting plays pivotal role power dispatching normal operations power grids however difficult challenging problem achieve high precision forecasting wind speed original sequence includes many nonlinear stochastic signals current conventional forecasting methods suitable capturing linear trends artificial neural networks easily fall local optimum paper proposes model combines denoising method dynamic fuzzy neural network address problems singular spectrum analysis optimized brain storm optimization applied preprocess original wind speed data obtain smoother sequence generalized dynamic fuzzy neural network utilized perform forecasting smaller simpler structure neural network model effectively achieve rapid learning rate accurate forecasting three experimental results cover min min min interval wind speed time series data demonstrate model satisfactorily approximates actual value used effective simple tool planning smart grids elsevier rights reserved
recently much attention paid sustainable development cities quality human life directly related environmental quality many people live cities place social economic cultural relationships certain issues environmental crises energy air noise pollution traffic jams factors alter quality human life therefore order improve quality human life attention sustainable development sustainability cities proposed sustainable building comprehensive significance begins conception negative positive impacts environment several descriptions sustainable green buildings created however pursue one goal create sustainable urban developments protection environment quality indoor environments materials energy consumption water usage impact building construction processes building maintenance factors affect environment sustainability sustainable building attempt relieve minus impacts environment occur building lifetime research investigates important factors relevance green buildings introduces several criteria sustainable housing
introduction skin skin care ssc neonatal period influences immediate breastfeeding outcomes early childhood especially duration exclusive breastfeeding aim investigated influence hours ssc given day one life infant young child feeding iycf practices one year life materials methods follow superiority randomized control trial rct ctri conducted teaching hospital located central gujarat mothers neonates girls boys previous study cohort rct ssc followed survey iycf practices first year life administered end infancy rct neonates received ssc beginning min hour birth average hours day life control group newborn placed next mother conventional care provided significant difference hypothermia incidences groups first two days life results difference groups far duration exclusive breastfeeding number times breastfed per day stoppage night feeds baby either group received bottled feeds received form extra lacteal feeds first months without significant group difference fewer ssc mothers reported difficulties breastfeeding extra lacteal supplementation mothers faced problems contacted physicians advice advised top milk given foods one year life mothers giving less recommended five food servings difference practices related hand washing food preparation storage feeding habits child illness episodes children conclusion iycf practices small group per guidelines positive trends seen fewer ssc mothers facing problems related breastfeeding study underpowered detect differences iycf practices relation ssc
catastrophic circumstances equipment failures electrical networks mostly caused emerging unidentified phenomena resonance ferroresonance phenomena investigated since many years ago manitoba hydro electrical network experienced ferroresonant states several times conditions may occur effect short circuit breaker phase failure transformer energizing load rejection accidental scheduled line disconnection plant outage one significant consequences resonant ferroresonant states apparent mis operation tripping protective devices inaccurate operation instrument transformers paper means pscad emtdc simulation software ferroresonant states analyzed manitoba hydro network ferroresonant states classified adequate modes ferro resonance detection tools furthermore kinds protective relays subjected ferroresonance simulated power network operation relays assessed
network scales rapidly new network applications emerge frequently bandwidth supply today internet could catch rapid increasing requirements unfortunately irrational using network sources makes things worse actual network deploys single next hop optimization paths data transmission best effort model leads imbalance use network resources usually leads local congestion hand multi path routing use aggregation bandwidth multi paths efficiently improve robustness network security load balancing quality service result multi path attracted much attention routing switching research fields many important ideas solutions proposed paper focuses implementing parallel transmission multi next hop data balancing network traffic reducing congestion aimed exploring key technologies multi path communication network could provide feasible academic support subsequent applications multi path communication networking proposed novel multi path algorithm based node potential network algorithm fully use network link resource effectively balance network link resource utilization
feature weighting vital step machine learning tasks used approximate optimal degree influence individual features salience feature changed different queries majority existing methods sensitive enough describe effectiveness features suggest dynamic weights dynamically sensitive effectiveness features order achieve propose differentiable feature weighting function dynamically assigns proper weights feature based distinct feature values query instance proposed weighting function extension previous work suitable single modal multi modal weighting problems hence referred general weighting function number parameters proposed weighting function fewer compared ordinary weighting methods show performance general weighting function proposed classification algorithm based notion dynamic weights optimized one nearest neighbor algorithm experimental results show proposed method outperforms ordinary feature weighting methods elsevier ltd rights reserved
purpose reviewthe purpose review provide update clinical public health economic consequences campylobacter infection recent findingscampylobacter leading bacterial cause food related illness importance enhanced chronic sequelae result acute infection recent advances include new clinical classification system neurological sequelae aim speeding accurate diagnosis appropriate treatment better understanding mechanisms underlying postinfectious functional gastrointestinal disorders emergence campylobacter concisus campylobacter showae potential aetiological agents inflammatory bowel disease new mechanism antimicrobial resistance campylobacters better appreciation economic costs summarycampylobacter infection common lead serious chronic sequelae considerable personal healthcare societal costs
transfer mass slender drop liquid axisymmetric extensional flow zero peclet numbers theoretically studied allow external flow small zero amount inertia problem governed three dimensionless parameters capillary number viscosity ratio lambda external reynolds number shown shape drop first approximation slender spindle suggesting usage bispherical coordinate system applying method presented szego pyne electrostatic capacity spindle analytical solution containing tonal functions obtained results show capillary number reynolds number increase drop becomes thinner longer surface area increases resulting larger mass transfer rates capillary number influential parameter elsevier rights reserved
objectivesthe pathophysiology migraine headaches clearly understood yet dopaminergic system hypothesized involved migraine pathogenesis aim study investigate catechol methyltransferase comt polymorphisms chronic headaches analyzed five single nucleotide polymorphisms snps comt materials methodsthe study population consisted patients migraine aura patients migraine without aura patients tension type headache healthy controls selected polymorphic markers included one causing hishis two non synonymous snps alaser valmet respectively two non polymorphic snps examined resultswe found significant differences genotypes allele frequencies haplotypes among patient groups controls conclusionsour results indicate five polymorphisms comt association migraineurs western japan possibility segments elsewhere gene may contain mutation responsible modifying expression comt activity enzyme important conclusively exclude entire comt gene involved migraine pathogenesis
network operators rely security services protect infrastructures different kinds network security policies defined globally distributed among multiple security middleboxes deployed networks however due complexity security policy inefficient directly employ existing pathwise enforcement approaches paper models enforcement network security policy set covering problem designs computational geometry based policy space analysis psa tool set operations security policy leveraging psa paper first investigates topological characteristics different types policies heuristic information reveals intrinsic complexities security policy guides design enforcement approach paper proposes scope wise policy enforcement algorithm selects modest number enforcement network nodes deploy multiple policy subsets greedy manner approach employed network topologies datacenter service provider efficiencies psa tool enforcement algorithm also evaluated compared header space analysis psa achieves much better memory time efficiencies set operations security policy additionally proposed enforcement algorithm able guarantee network security within reasonable number enforcement network nodes without introducing many extra rules
global navigation satellite systems gnss like gps also galileo glonass beidou represent important infrastructure society provide position timing numerous applications gnss rather complex system consisting around satellites number monitor stations plus control center billions gnss receivers represent user segment receivers monitor stations receive weak satellite radio signal thus susceptible interference like jamming spoofing paper outlines core operation principles satellite navigation describe kind interference analyze impacts different types interference attacks result different effects target receiver attack schemes categorized within paper reported incidents summarized well potential impact gnss vulnerability critical infrastructure well known countermeasures user receiver level system level outlined discussed suitability political socioeconomic context gnss vulnerability described emphasizing large impact potential disruption gnss service
paper graphical user interface gui developed matlab environment educational research purpose field control engineering interactive user friendly software focuses behavior performance analysis linear time invariant control system time well frequency domain user input dynamics system form transfer function state space format gui facility dropdown list user get information poles zeros transient response analysis step impulse input bode nyquist nichols diagrams report regarding controllablity observability system also generated using toolbox toolbox three sections one entering dynamics system state space transfer function form second selecting different performance parameters analyzed last output panel figures reports moreover user simultaneously compare performance two systems
predation seen important source mortality many endangered species including piping plover however predation managed lethal methods birth control excluding predators nests nevertheless managing predator population order protect threatened prey population uncertain outcomes making monetary expenditures required manage predators less appealing developed methodology utilizes stochastic coupled predator prey population viability analysis determine efficacy using predator exclosures protect piping plover nests versus using lethal birth control measures one principal predators red fox found implementing predator exclosures led slightly higher final abundances plovers compared lethal birth control foxes moreover joint effort predator control predator exclosures resulted considerably higher final plover abundance compared either option alone additionally may situations certain demographic data predator population population size age distribution known manager evaluated effect demographics predator control management option chosen found efficacy different management options change depending starting demographics fox population emphasize implementation type model managing predator sake prey order make informed management decisions could save money ensuring better protection endangered species
objectives temporomandibular disorder tmd involves dysfunction temporomandibular joint associated muscles mastication causing pain chewing limitation jaw movement pain exact pathophysiology tmd completely understood thought hyperfunction muscles mastication places stress temporomandibular joint leading degeneration joint associated symptoms hypothesize chemodenervation muscles mastication incobotulinumtoxina xeomin decrease stress temporomandibular joint improve pain associated temporomandibular joint muscle disorder tmjd methods twenty patients randomized incobotulinumtoxina units saline injection masticatory muscles patient reported pain scale recorded week intervals following injection weeks patients received saline injection initially assessed reduction pain first week interval still significant pain rolled incobotulinumtoxina arm results preinjection pain scores similar patients statistically significant reduction pain score placebo group one month overall larger drop average pain scores patients injected incobotulinumtoxina initially patients initially injected placebo crossed incobotulinumtoxina group similar results seen examining composite masticatory muscle tenderness scores significant change usage pain medication conclusions demonstrate utility incobotulinumtoxina treating patients tmd pain despite pain medication usage conventional treatments
melatonin produced pineal gland well many organs including enterochromaffin cells digestive mucosa melatonin powerful antioxidant resists oxidative stress due capacity directly scavenge reactive species modulate antioxidant defense system increasing activities antioxidant enzymes stimulate innate immune response direct indirect actions addition dysregulation circadian system observed related alterations colonic motility cell disruptions due modifications clock genes expression gastrointestinal tract activities melatonin mediated melatonin receptors serotonin cholecystokinin cck receptors via receptor independent processes levels melatonin gastrointestinal tract exceed times blood concentrations also estimated times melatonin gut pineal gland gut melatonin secretion suggested influenced food intake low dose melatonin treatment accelerates intestinal transit time whereas high doses may decrease gut motility melatonin studied adjuvant treatment several gastrointestinal diseases including irritable bowel syndrome ibs constipation predominant ibs ibs diarrhea predominant ibs ibs crohn disease ulcerative colitis necrotizing enterocolitis purpose review provide information regarding potential benefits melatonin adjuvant treatment gastrointestinal diseases especially ibs crohn disease ulcerative colitis necrotizing enterocolitis elsevier inc rights reserved
explored associations torture history physical health symptoms karen refugees newly arrived united states conducted retrospective cross sectional analysis electronic health data collected initial refugee health screening exam unique analysis exploration relationships torture exposure war trauma presenting physical psychological health issues identified unique effects torture physical health beyond trauma exposure overall sample found high prevalence underlying infectious conditions pain hypercholesterolemia regardless torture exposure discuss effects war trauma torture experiences physical exam findings implications future research
paper proposes technique shedding voltage collapse voltage load shedding uvls based optimal power flow procedure opf transient stability constraints transient stability constraints optimal power flow tsc opf solve problem used meta heuristic approach learn method genetic algorithms objective method get shedding tensions necessary limits ensure electrical network operating point away point voltage collapse developed algorithm tested ieee bus network model
malocclusion caused abnormal jaw development muscle overuse mastication results abnormal mechanical stress tissues surrounding temporomandibular joint tmj excessive mechanical stress soft hard tissues around tmj involved pathogenesis inflammatory diseases including osteoarthritis related fibrosis possible cause joint stiffness however cellular molecular mechanisms underlying fibrosis around tmj remain clarified established cell line fibroblast like synoviocytes flss derived mouse tmj examined whether rho associated coiled coil forming kinase rock actin myocardin related transcription factor mrtf gene regulatory axis positively regulates myofibroblast differentiation status flss found flss extensively expressed markers smooth muscle actin sma type collagen inhibitor actin polymerizing agent rock iii actin depolymerizing agent cytochalasin inhibitor mrtf serum response factor regulated transcription ccg clearly suppressed mrna levels sma type collagen flss differentiation attenuator fibroblast growth factor suppressed filamentous actin formation clearly suppressed mrna levels sma type collagen flss results strongly suggest rock actin mrtf axis promotes fibrogenic activity synoviocytes around tmj findings partially clarify molecular mechanisms underlying emergence tmj may aid identifying drug targets treating condition molecular level
hierarchical modulation scheme proposed upgrade existing digital broadcast system satellite satellite radio adding data transmission hierarchical modulation consists basic constellation original system secondary constellation carries additional data upgraded system upgraded system hierarchical modulation backward compatible sense receivers deployed original system continue receiving data basic constellation new receivers designed receive data carried secondary constellation well basic constellation analysis performed show tradeoff bit rate data secondary constellation penalty performance receiving basic constellation
classification based image sets recently attracted increasing interests computer vision pattern recognition community finds numerous applications real life scenarios classification surveillance videos multi view camera networks personal albums image set based face classification highly depends consistency coverage poses view point variations subject gallery probe sets paper explores synthetic method create unseen face features database thus achieving better performance image set based face recognition considering high symmetry human faces multiple synthetic instances virtually generated make missing parts enrich variety database respect classification framework resort reverse training due high efficiency accuracy performance proposed approach synthetic examples based reverse training seat fully evaluated honda ucsd cmu mobo youtube celebrities three benchmark datasets comprising facial image sequences extensive comparisons state art methods corroborated superiority approach
background periodontal disease commonest infectious disorder leads tooth loss linked various systemic diseases including various types cancer aim study provide systematic review meta analysis relationship edentulism pancreatic cancer patients methods initial review references selected eight studies concerning periodontitis edentulism sufficient quantitative information allow examine risk used relative risks rrs hazard ratios odds ratios measure association periodontitis edentulism employed random effects models obtain summary risks also provide measures study differences possible biases results summary periodontitis confidence interval edentulism evidence heterogeneity either variable evidence publication bias studies included reports three continents suggesting association generalizable studies adjusted variables thought associated gender smoking bmi diabetes alcohol conclusions using meta analysis periodontitis edentulism appear associated even adjusting common risk factors yet mechanisms linking oral disease uncertain could related changes oral microbiome area current research
objectivethe interpersonal theory suicide ipts model fully tested clinical eating disorder population methodparticipants completed questionnaires assessing suicidal ideation suicide attempts constructs ipts logistic regressions determined whether thwarted belongingness perceived burdensomeness associated lifetime among endorsed lifetime logistic regressions used determine whether elements acquired capability suicide fearlessness death painful provocative events associated lifetime resultssixty five participants lifetime lifetime thwarted belongingness perceived burdensomeness associated lifetime painful provocative events associated lifetime discussionthe ipts partially supported targeting interpersonal variables may important treating preventing suicidality wiley periodicals inc int eat disord
many industrial applications precise delivery fluid required ratio blending delivery system etc one application petroleum product delivery system price petroleum products increasing day day important deliver exact demanded quantity product customer delivery systems digital control valve used paper deals simulation digital control valve motivation behind know behavior digital control valve develop different control strategies fluid delivery done accuracy precision
backgroundthe extent earlier age onset reflection increased genetic risk major depression still unknown previous biometrical research provided mixed empirical evidence genetic overlap demonstrated relevant molecular polygenic risk incorporation phenotype could enhance future genetic studies methodsthis research estimated snp based heritability china oxford vcu experimental research genetic epidemiology converge case control sample case common single nucleotide polymorphism heritability also examined across high low median split groups best linear unbiased predictor blup scores polygenic risk split halves used predict distributions genetic risk across early late compared presence self reported family history also examined predictor resultsao significantly heritable polygenic risk derived aggregated effects common genetic variants significantly predict analysis modestly significantly lower cases first degree genetic conclusionsfindings indicate associated greater self reported genetic risk cases yet associated common variant polygenic risk future studies early may benefit examination important moderating variables early life events
work attempts experimental studies finite element model updating actual rotor system mounted ball bearings using inverse eigen sensitivity method iesm iesm applied state space representation equations motion used identify bearing stiffness damping shaft material damping parameters non proportional viscous damping model used model bearing shaft material damping experimental identification viscous coefficient shaft material damping found available literature work attempts well updated model validated accuracy comparing predicted frequency response obtained experiments finally shown updated finite element model rotor system efficiently used predict unbalance rotor elsevier ltd rights reserved
dimensionality reduction aims reveal salient properties high dimensional data low dimensional representation space two elements stipulate success approach definition notion pairwise relations spaces measuring mismatch relationships representations data paper introduces new method termed kernel based entropy dimensionality reduction kedr measure embedding quality based stochastic neighborhood preservation involving gram matrix estimation renyi alpha entropy proposed approach data driven framework information theoretic learning based infinitely divisible matrices instead relying upon regular renyi entropies kedr also computes embedding mismatch parameterized mixture divergences resulting improved preservation local global data structures approach validated synthetic real world datasets compared several state art algorithms including stochastic neighbor embedding like techniques approach data driven extension perspective kernel based gram matrices terms visual inspection quantitative evaluation neighborhood preservation obtained results show kedr competitive promising method
exact solution anti symmetric quadratic truly nonlinear oscillator derived first integral nonlinear differential equation governs behavior oscillator exact solution expressed piecewise function including jacobi elliptic cosine functions fourier series expansion exact solution also analyzed coefficients computed numerically also show fourier coefficients decrease rapidly consequently using provides accurate analytical representation exact periodic solution approximate solutions containing two harmonics well rational harmonic representation obtained compared exact solution elsevier inc rights reserved
large scale network graph analysis received considerable attention recently graph mining techniques often involve iterative algorithm implemented variety ways using pagerank model problem look three algorithm design axes work activation data access pattern scheduling investigate impact different algorithm design choices using design axes design test variety pagerank implementations finding data driven push based algorithms able achieve performance standard pagerank implementations graphlab design choices affect single threaded performance well parallel scalability implementation lessons guide efficient implementations many graph mining algorithms also provide framework designing new scalable algorithms
paper presents design evaluation web based collaborative learning environment called educo learning practicing team based exercises computer science software engineering courses educo defining characteristic integrating number services software development activities example project management requirements engineering design programming integrated shared workspaces social networking facilities enhance collaboration among students instructors conducted controlled experiment evaluate effectiveness system three iteration programming project total second year students attended object oriented programming course participated experiment results show system found affect student programming performance improved student engagement satisfaction working teams results imply system shared workspaces social networking services potential enhance learning outcomes students working teams features integrated collaborative learning environments wiley periodicals inc comput appl eng educ view article online doi
introduction enhanced understanding pathogenesis myeloproliferative neoplasms mpn led rapid introduction novel therapeutic agents clinical practice knowledge genetic landscape jak mpl calr commonly mutated genes increasing used model novel effective therapies histone deacetylases hdac heavily involved epigenetic modulation aberrant expression demonstrated vitro vivo various mpn number hdac inhibitors hdaci since developed aim reverse epigenetic dysregulation areas covered role hdaci mpn reviewed detail addition update currently available clinical trial information pivotal importance understand agents fit current therapeutic strategy management mpn expert opinion hdaci certainly role management mpn clarification dosing scheduling required moreover whether agents used sequentially agents jak inhibitors combination area active investigation
conducted three experiments determine engaging self enhancing humor alleviate state anxiety associated anticipated stressful event three experiments participants imagined take stressful math test experiment participants engaged self enhancing humor anticipating taking test experienced less state anxiety engaged self defeating humor humor experiment demonstrated engaging self enhancing humor reduced state anxiety mere instructions adopt non serious humorous outlook stressful situation experiment revealed self enhancing humor alone induced participants adopt humorous perspective stressful math test participants responded least state anxiety also given instructions use humor reframe math test collectively findings corroborate extend previous correlational studies showing self enhancing humor alleviate state anxiety associated stressful event
twenty three percent heart failure patients memory loss objectives characterize major allelic frequency variants apolipoprotein apoe gene patients evaluate differences memory serum brain derived neurotrophic factor bdnf levels based apoe epsilon allele estimate effect sizes ess confidence intervals cis pilot patients enrolled completed recall delayed recall memory measured baseline weeks serum collected baseline weeks seven patients apoe epsilon allele significant differences found recall delayed recall memory serum bdnf levels based apoe epsilon allele ess small medium cis indicated precision small future studies needed fully understand genotypic neuropsychological phenotypic variables influence response computerized cognitive training
paper sets explore possibility citizen led surveys provide better coverage populations specifically hard reach poorer areas international standardized household surveys basis many estimates used assessing progress toward meeting mdgs sdgs hypothesis based argument local volunteer enumerators citizen led surveys likely sensitive specificities local population distribution recent changes centrally trained may effective reaching hard reach groups nomadic groups urban slums test hypothesis results uwezo meaning capability surveys compared regional level contemporaneous dhs surveys kenya tanzania uganda estimates access water electricity overall national level find uwezo estimates access clean water lower statistically significant level dhs differences statistically significant level particular dhs values much higher regions high concentrations nomads urban slums implying uwezo surveys catch poverty suggestion therefore citizen surveys uwezo provide better accurate coverage poorest poor using lowest estimate percentage missing urban slums extrapolating developing countries estimated million missing sampling frames standardized household surveys worldwide important implications leave one behind appeal secretary general data revolution suggestions made progress improved population estimates elsevier ltd rights reserved
overactive bladder oab affects considerable proportion men women united states associated significant costs quality life qol reduction medication remains mainstay treatment increasing interest use alternative medicine form acupuncture reviewed literature role acupuncture managing oab narrative review compiled searching electronic databases pubmed medline scopus embase clinical studies involving acupuncture treating oab databases searched time inception september clinician articles reporting results related use acupuncture oab key search terms acupuncture overactive bladder bladder instability urgency urinary incontinence articles english translated english included initial animal studies suggest several biochemical mechanisms action underlying effect acupuncture oab suppression experience humans includes two case series six comparative trials studies demonstrated subjective improvement oab symptoms reported objective improvement urodynamic studies notably comparative trials showed benefit acupuncture comparable antimuscarinic treatment despite limitations existing studies serve promising foundation suggesting role acupuncture alternative therapy oab well designed studies required investigate optimal technique outcomes
water important element life water pollution common threat concerning public health pakistan order check groundwater quality drinking purpose research conducted lyallpur town industrial area district faisalabad area divided four zones sampling groundwater quality evaluation sixty water samples existing sources along coordinates four soil samples taken understand mobility behavior contaminants paharrang drain passing research area expected main source soil groundwater contamination therefore sampling points drinking water samples selected keeping consideration relative position drain collected samples analyzed physio chemical parameters tds bicarbonates results obtained samples compared guidelines values results represented mapping quality parameters using arcview gis idw used raster interpolation long term trends groundwater quality parameters revealed increasing effect contamination respect time soil analysis study area showed sandy loam soil texture overall consequently showing high rates infiltration soil concluded water partially fit drinking specifically due increased concentration tds chlorine hardness direct use groundwater drinking purpose may cause health issues gastrointestinal illness nausea eye nose irritation etc
paper team cooperative unmanned aerial vehicles uavs maintains desired geometrical formation tracking reference trajectory using new control approach decentralized learning based model predictive control dlbmpc new control technique combines statistical learning along control engineering providing guarantees safety robustness convergence ability proposed dlbmpc controller solving problem formation team cooperative uavs solved simulation designed controller respects general formation constraints known reynolds rules flocking main contribution paper lays stabilization group cooperative uavs desired formation tracking reference trajectory using dlbmpc presence model uncertainties
aim study compare prevalence cardiovascular cvd related comorbidities patients ankylosing spondylitis psoriatic arthritis psa psoriasis primary care matched cohorts matched retrospective cohort study used primary care consultation database three cohorts constructed using patients read code diagnosis psa cohort compared ratio matched cohort prevalence cvd related comorbidities hypertension ischaemic heart disease hyperlipidaemia diabetes mellitus identified first consultation comorbid read code inflammatory condition interest prevalence cvd related comorbidities compared inflammatory cohort matched cohort using fisher exact test ninety four psa patients identified compared matched cohorts prevalent cvd related comorbidity patients hypertension matched also case psa matched differences seen prevalence cvd related comorbidities psa compared matched cohorts findings provide comparisons cvd related comorbidities patients psa alone specifically demonstrating increased prevalence hypertension psa cohorts compared matched cohorts supports argument evidence need screening intervention around cvd comorbidities inflammatory conditions
erectile dysfunction premature ejaculation two forms male sexual disorder psychological physical features cognitive attentional affective components investigated separately lack knowledge role played cognitive attentional syndrome onset maintenance aim present study investigate possible contribution perseverative thinking styles thought control strategies development maintenance authors hypothesized modes processing might constitute cognitive attentional syndrome specific disorders sustained particular metacognitive beliefs semistructured interview administered participants order assess metacognitive beliefs cognitive attentional processes results suggest individuals adopt range cognitive attentional strategies aimed improving sexual performance endorse positive negative metacognitive beliefs thinking responses overall cognitive attentional patterns worsened negative internal states reduced sexual excitement detached bodily sensations hindered sexual functioning preliminary findings suggest perseverative thinking thought control strategies metacognitive beliefs may play key role onset maintenance male sexual dysfunction
effect concentration carbohydrates viscoelastic properties corn rice starch discussed paper texture starch pastes estimated using fractional rheological linear standard solid model rheological parameters model identified changes different values sugar concentrations tested starches discussed practical applicationthe fractional rheological models useful control biomaterial texture needs final product particularly significant point view materials engineering proposed method interpretation results rheological measurements pastes allows comprehensive estimation analyzed biomaterial texture
depression heart rate variability hrv conditions systemic inflammation shown patients experimental animal models hrv suggested early indicator sepsis sensitivity hrv derived parameters severity sepsis however remains unclear study modified clinically relevant porcine model peritonitis induced sepsis order avoid development organ failure test sensitivity hrv non severe conditions anesthetized mechanically ventilated instrumented domestic pigs sexes sepsis induced fecal peritonitis dose feces adjusted antibiotic therapy administered avoid multiorgan failure experimental subjects screened induction sepsis septic animals sepsis hyperdynamic circulation increased plasma levels inflammatory mediators developed within induction peritonitis sepsis progress multiorgan failure spontaneous death experiment despite modest requirement vasopressor therapy animals pronounced reduction hrv elevation heart rate developed quickly within time constant hrv parameter tinn upon induction sepsis maintained throughout experiment frequency domain analysis revealed decrease high frequency component reduction hrv parameters elevation heart rate preceded sepsis associated hemodynamic changes several hours time constant systemic vascular resistance decline pronounced fast reduction hrv occurred setting moderate experimental porcine sepsis without organ failure inhibition parasympathetic cardiac signaling probably represents main mechanism hrv reduction sepsis sensitivity hrv systemic inflammation may allow early detection moderate sepsis without organ failure impact statement pronounced fast reduction heart rate variability occurred setting moderate experimental porcine sepsis without organ failure dominant reduction heart rate variability found high frequency band indicating inhibition parasympathetic cardiac signaling main mechanism heart rate variability reduction sensitivity heart rate variability systemic inflammation may contribute early detection moderate sepsis without organ failure
propose new multi secret images sharing scheme provides high level provable security fast sharing reconstruction procedures uses simple boolean operations conjointly secure stream cipher cryptographic hash function order enable efficient sharing secret images among set different participants approach overcomes security weakness detected existing similar schemes provides additional advantages high sensitivity alterations ability share heterogeneous images diverse resolutions obtained experimental results show effectiveness robustness method compared existing schemes particularly ability ensure higher security level competitive computational performances
mobile adhoc network dynamic nature operates completely infrastructure less environment discovers way routes dynamically reach destination securing dynamic way route known establishing communication always challenge mobile hoc network existing secure routing protocols target evade specific type attacks malicious behaviour nodes networks propose novel secure way routing protocol securing dynamic way routes manet provides unique session key route secure data communication moreover authenticates data packets using asymmetric cryptography secures routing field message using two way asymmetric cryptography proposal implemented tested assessing protocol performance also compared protocol secure routing protocols evaluating performance
aim compare differences contraceptive characteristics knowledge emergency contraception ecp among women used ecp unprotected intercourse sought abortion methods questionnaire survey conducted hungarian university hospital among women ecp prescribed unprotected intercourse well women presented termination pregnancy january november knowledge ecp experience attitudes toward ecp use targeted results availability ecp well known still greatly underutilized applied women resorted abortion primarily ecp group consisted experienced condom failure significantly often odds ratio followed cases ecp applications consequence using kind contraception fewer one third abortion seekers previously used ecp one fifth knew obtain appropriate awareness ecp influenced information obtained health care providers adjusted odds ratio aor school education aor conclusions thorough education needed provide deeper knowledge ecp use contraceptive counseling women seeking abortion including contraceptive mishaps unintended pregnancy prevented ecp
intimate partner violence research focused almost exclusively physical sexual intimate partner violence opposite sex relationships paying little attention intimate partner violence experienced men sex relationships emerging research focusing intimate partner violence among male male couples focused largely physical sexual violence little consideration unique forms emotional violence experienced gay men ten focus group discussions gay bisexual men conducted examine perceived typologies antecedents experiences emotional violence occur male partners participants described emotional violence threatening form intimate partner violence driven largely factors including power differentials gender roles internalised homophobia results indicate gay bisexual men perceive emotional intimate partner violence commonplace better understanding emotional violence within male male relationships vital inform intimate partner violence prevention efforts accurate measurement intimate partner violence gay men
purpose identify incidence risk factors recurrence discontinuation successful antimuscarinic therapy patients overactive bladder oab materials methods prospective multicenter trial patients antimuscarinic agents weeks showed successful response enrolled successful response defined answering benefit patient perception treatment benefit answer lesser points patient perception bladder condition ppbc enrolled patients discontinued antimuscarinics evaluated recurrence ppbc oab symptom score oabss months primary purpose identify recurrence rate secondary purpose reveal risk factors results four hundred forty one patients enrolled patients completed month follow enrolled patients showed points ppbc points oabss points ipss quality life represented successful response using antimuscarinics cumulative rates recurrence months respectively among patients show recurrence months patients followed patients patients showed recurrence months univariate multivariate analyses recurrence oab wet risk factor recurrence months discontinuation conclusions discontinuation antimuscarinic therapy successful treatment resulted high recurrence rate time oab wet independent risk factor recurrence
last years greater interest using computers education particular engineering education software programs great impact studying many physical phenomena otherwise could described using complex mathematical algorithms furthermore computer simulation studied behavior many engineering systems launching production however focus many times exclusively could handicap future engineers different perspective lack real measurement future data manipulation interpretation time experimental stands could often expensive many university laboratories article author presents methodology could compromise use software dedicated programs really electrical systems use electronic simulators releases university laboratory expensive acquisitions put large gap practice theoretical concepts based block system diagram real system constructed electronic simulator using basic operational amplifier structures circuits result electronic system simulator
thermodynamic stabilities four natural prohead packaging rna prna three way junction nanomotifs seven phi prna deletion mutant nanomotifs investigated using optical melting three component rna system data reveal prna wjs stable phi prna stability contributes unique self assembly properties prna thus ultrastable prna motifs suggest new scaffolds prna based nanotechnology present data demonstrating prna wjs differentially respond presence metal ions comparison data free energies predicted currently available rna secondary structure prediction programs shows programs accurately predict multibranch loop stabilities results expand existing parameters used rna secondary structure prediction sequence order better inform rna structure function hypotheses guide rational design functional rna supramolecular assemblies
improved monte carlo method standard less analysis laser induced breakdown spectroscopy libs presented concentrations libs found fitting model generated synthetic spectra experimental spectra current version libs based graphic processing unit gpu computation reduces analysis time several seconds per spectrum sample previous version libs based central processing unit cpu computation requested unacceptably long analysis times minutes per spectrum sample reduction computational time achieved massively parallel computing gpu embeds thousands processors shown number iterations gpu exceeds cpu factor dimentional parameter space yet requires fold shorter computational time improved gpu libs outperforms cpu libs terms accuracy precision analysis time performance tested libs spectra obtained pelletized powders metal oxides consisting cao feo mgo tio simulated products steel industry steel slags demonstrated gpu based libs capable rapid multi element analysis relative error percent sufficient industrial applications steel slag analysis results improved gpu based libs positively compared cpu based libs well results standard calibration free libs based boltzmann plot method elsevier rights reserved
quantum proof randomness extractors important building block classical quantum cryptography well device independent randomness amplification expansion furthermore also useful tool quantum shannon theory known extractor constructions quantum proof whereas others provably gavinsky stoc argue theory operator spaces offers natural framework studying extent extractors secure quantum adversaries first phrase definition extractors bounded norm condition normed spaces show presence quantum adversaries corresponds completely bounded norm condition operator spaces show high min entropy extractors well extractors small output always approximately quantum proof also study generalization extractors called randomness condensers phrase definition condensers bounded norm condition definition quantum proof condensers completely bounded norm condition seeing condensers bipartite graphs find bounded norm condition corresponds instance well studied combinatorial problem called bipartite densest subgraph furthermore using characterization terms operator spaces associate condenser bell inequality two player game classical quantum strategies one one correspondence classical quantum attacks condenser hence get every quantum proof condenser includes particular quantum proof extractors bell inequality violated quantum mechanics
prospective study soccer injuries involving male youth players ages conducted greek soccer clubs course one year total players sustained injuries incidence injuries injuries per soccer time per player common types injuries sprains strains surprisingly found increase injury incidences occurred practice fifty eight injuries required medical assistance majority injuries located lower extremities collision players common activity time injury accounting injuries conclusion study evidence studies suggests youth soccer relatively low risk sport however substantial amount injuries could prevented necessary identify risk factors associated types injuries
depression alzheimer disease two common closely intertwined diseases elderly bio markers early diagnosis would helpful clinicians brain areas involved depression alzheimer disease olfactory processing overlap leading suggestions olfaction could constitute potential marker diseases review literature relevant clinical olfactory fields consider olfactory measures factors could serve markers diseases reported repeatedly alteration odor identification alzheimer disease depression observations provide strong arguments olfactory marker may serve complementary tool early screening patients odor threshold detection odor hedonic aspect may constitute complementary markers efficacy depression therapy however numerous contradictory data innovative methods required investigate whether investigations olfaction usefully contribute routine clinical practice elsevier ltd rights reserved
work presents applications inductive topological approach calculation transfer function cascading network control system method provides versatile effective way counting graphs contribute translating algebraic contribution contributing graphs simple reflect morphology original control system signal flow graph application method results presented cell network derive analytical formula relating omega filter size aeuro broken vertical bar formula used designing preset frequency range self loaded filters varying size also derive general expressions sensitivities use observe sensitivity insensitivity filter transition various frequency ranges relaxation times importantly filter sizes
new type mechanically stabilised earth structure composed geosynthetic tubes filled expanded clay lightweight aggregate backfill geosynthetic reinforcement introduced results study demonstrate alternative solutions expanded clay lightweight aggregates used interaction geosynthetics comparison classical soil new type geosynthetic tubes filled dynamically expanded clay lightweight aggregate tested situ compressive loading geosynthetic tube instrumented load cell transducers characteristic cross section obtained three dimensional scanner measurements loading next simplified engineering formulation geosynthetic tubes compressive loading unloading evaluated including influence volume variation tube based classical approach soil mechanics produces required design tensile force tube dependent geosynthetic stiffness experimental results compressive loading tests compared analytical equations results discussed show influence geosynthetic stiffness behaviour tube terms loading capacity volume variation cross section tube agreement theoretical analyses experimental results reasonably good formally accepted given volume variation geosynthetic tube
study examined college women instrumentality expectations combining work family predicted early career development variables specifically undergraduate women completed measures instrumentality traits ambition assertiveness risk taking willingness compromise career family anticipated work family conflict traditionality career choice leadership aspirations occupational engagement high levels instrumentality associated strong leadership aspirations occupational engagement inverse relationship emerged selection traditional career less anticipation work would interfere time spent family positive relationship emerged high leadership aspirations anticipation family would strain work additionally anticipating work would interfere time spent family positive relationship occupational engagement findings discussed recommendations career counseling young women provided
study examined psychometric properties child adjustment parent efficacy scale developmental disability capes brief inventory assessing emotional behavioral problems children developmental disabilities aged years well caregivers self efficacy managing problems sample parents participated study children ages ranged exploratory confirmatory factor analyses supported item three factor model capes child adjustment items describing behavioral items emotional items problems items describing prosocial behavior three additional items included due clinical usefulness contributed total problem score factor analyses also supported item one factor model capes self efficacy psychometric evaluation capes revealed scales satisfactory good internal consistency well good convergent predictive validity instrument public domain free practitioners researchers use potential uses measure implications future validation studies discussed elsevier ltd rights reserved
purpose reviewthe exposome concept proposes comprehensive assessment environmental exposures prenatal period onwards however determining exposure timing especially prenatal period major challenge environmental epidemiologic studies recent findingsfor decades teeth used estimate long term cumulative exposure metals recently developed high dimensional analytical methods combine sophisticated histological chemical analysis precisely sample tooth layers correspond specific life stages potential reconstruct exposome second third trimesters prenatal development early childhood summarya retrospective temporal exposomic approach precisely measures exposure intensity timing prenatal early childhood development would substantially aid epidemiologic investigations particularly case control studies rare health outcomes
article three objectives first examines whether latest version simcity achieve learning objectives related systems thinking problem solving creativity regional understanding classroom second examines whether game influences student interest planning third considers whether game impacts students perception discipline using instructor observation students game creations surveys find game achieve aforementioned learning objectives increase student interest increase perception planning creative fun results implications instruction student recruitment perceptions field
macrophyte biological index rivers ibmr method describes eutrophication well organic pollution single index value presence hippuris vulgaris water lack thereof may affect ibmr value potential effects water pollution decis containing deltamethrin water sediment plant system objectives research insecticide often occurs soil water contamination therefore aim present study answer question decis stress factor affects growth vulgaris determine persistence deltamethrin water sediment plant system study conducted different trophic levels consecutive years half life deltamethrin water estimated test system found vulgaris demonstrated ability survive water sediment environment contaminated decis despite inhibition plant development presence insecticidal formulation plant growth much slower compared control tolerance index ranged lower values obtained higher concentration phosphorus nitrogen potassium long term studies vulgaris grown different trophic conditions indicate despite plant ability survive contamination decis timing macrophytes assessment crucial assess occurrence development plant ecological status water
given threat environmental degradation land deterioration conventional agriculture modern greenhouse cultivation attracted increasing attention effective alternative however high energy consumption greenhouse systems concerning given need limit environmental impact human activities solar integration agricultural greenhouse form modern solar greenhouse potential simultaneously respond declining availability suitable land imperative minimum emissions review overview china progress towards development modern solar greenhouses well attempts mitigate effects heat loss shadowing poor light condition presented promising prospect shown china modern solar greenhouses present levels performances costs exemplified photovoltaic greenhouses practicable payback period less years additionally application advanced solar technology better thermal storage power generating light utilization balance proved effective promote solar energy utilization modern solar greenhouses
subthalamic nucleus stn globus pallidus internus gpi recently shown encode reward studies performed humans investigated stn gpi encoding reward loss valence humans parkinson disease test hypothesis stn gpi neurons would change firing rate response reward loss related stimuli recorded activity individual neurons participants performed behavioral task task action choices associated potential rewarding punitive neutral outcomes found stn gpi neurons encode valence related information action control proportion valence responsive neurons greater stn compared gpi stn reward related stimuli mobilized greater proportion neurons loss related stimuli also found surprising limbic overlap sensorimotor regions stn gpi overlap greater previously reported findings may help explain alterations limbic function observed following deep brain stimulation therapy stn gpi wiley periodicals inc
satiation satiety key terms come widely used help understand processes involved appetite control satiation considered signals processes bring meal end whereas satiety signals processes following end meal inhibit eating hunger returns protein effective food macronutrient providing satiating effect thus formulating foods increased protein contents help modulate food intake promoting body weight loss body weight maintenance thereafter mechanisms explaining protein induced satiety primarily nutrient specific course mathematically related satiety different proteins cause different nutrient related responses anorexigenic hormones glucagon like peptide glp release evoked high protein meal stimulated carbohydrate content also cholecystokinin cck peptide pyy release stimulated high protein meal sensory cognitive post ingestive post absorptive signals determine jointly feeling satiation satiety oral perception cues also contribute increased expectations satiating capacity oral residence time mouth handling longer laborious present review authors want obtain overview satiating ability dietary protein role satiation satiety could really significant showing food industry path developing protein rich satiating foods response consumer demand elsevier ltd rights reserved
paper presents concept experimental results mixed signal instrumentation system featuring high voltage cmos asic system dedicated operate ofet based gas sensor composed high voltage amplifiers used bias ofet low voltage analog signal processing chain bit adc bit dac digital soc fpga implemented soc controls whole system particular generates specific control signals ofet gate voltage high voltage supply generated chip means dedicated charge pumps
suggested neurotrophins involved etiopathogenesis attention deficit hyperactivity disorder adhd study aimed investigate whether differences serum brain derived neurotrophic factor bdnf glial derived neurotrophic factor gdnf nerve growth factor ngf neurotrophin ntf levels children adhd healthy controls total treatment naive children combined presentation adhd healthy controls aged years enrolled study severity adhd symptoms determined scores conners parent rating scale revised short conners teacher rating scale revised short severity depression anxiety symptoms children evaluated self report inventories serum levels neurotrophins measured using commercial enzyme linked immunosorbent assay kits multivariate analysis covariance mancova revealed significant main effect groups levels serum neurotrophins effect independent age sex severity depression anxiety analysis covariance ancova indicated mean serum gdnf ntf levels adhd patients significantly higher controls however serum bdnf ngf levels show significant differences groups correlations levels serum neurotrophins severity adhd observed results suggest elevated serum gdnf ntf levels may related adhd children
standard replacement therapy addison disease restore normal circadian rhythm fact hydrocortisone replacement patients likely induces disrupted sleep given healthy sleep plays important role improving quality life optimizing cognition ensuring affect regulation aim study investigate whether poor quality life mood alterations memory complaints reported patients associated disrupted sleep patterns sixty patients matched healthy controls completed battery self report questionnaires assessing perceived physical mental health short form mood beck depression inventory sleep quality pittsburgh sleep quality index cognition cognitive failures questionnaire latent variable model revealed although significant direct effect quality life indirect effect sleep significantly greater furthermore although direct effect cognitive functioning indirect effect sleep significant overall model showed good fit comparative fit index root mean square approximation standardized root mean square residual findings suggest disrupted sleep disease per may induce poor quality life memory impairment affect dysregulation patients think improving sleep architecture may improve cognitive affective physical functioning elsevier inc rights reserved
simulate welding induced transient thermal stress deformation large scale models accelerated explicit method acexp graphical processing units gpu parallel computing program finite element method fem developed accelerated explicit method two stage computation scheme employed first computation stage based dynamic explicit method considering characteristics welding mechanical process controlling temperature increment time scaling parameter second computation stage static equilibrium computation scheme implemented dynamic thermal loading obtain static solution transient thermal stress welding deformation demonstrated developed gpu parallel computing program good scalability large scale models million degrees freedom validity accelerated explicit method verified comparing transient thermal stress deformation computed implicit fem finally welding deformation residual stress structure model assembled nine high strength steel plates weld lines efficiently analyzed acexp gpu parallel computing within computed welding deformation agreed well measured results good accuracy obtained
dimensional non linear optical waves coherently excited resonant medium doped erbium atoms described dimensional non linear schrodinger equation coupled self induced transparency equations system via hirota method symbolic computation linear forms one two soliton solutions obtained asymptotic analysis conducted suggests interaction two solitons elastic bright solitons obtained fields dark ones field electric field polarization resonant medium induced electric field population inversion profile dopant atoms head interaction bidirectional two solitons overtaking interaction unidirectional two solitons seen influence averaged natural frequency solitons studied affect velocities solitons amplitudes solitons fields increase decreasing decrease increasing decreasing fields one peak one soliton turns two peak one well interaction type changes interaction two one peak ones one peak one two peak one field influence solitons found results paper might potential applications design optical communication systems produce bright dark solitons simultaneously
one branch stereo matching video stereo matching becomes significant computer vision applications conventional stereo matching methods static images would cause flicker frames worse matching results propose joint motion based square step jmss method stereo video matching motion vector introduced one component support region building raw cost aggregation aggregate raw cost along two directions support region finally winner take strategy determines best disparity hypothesis experimental results show jmss method outperforms state art stereo matching methods test sequences abundant movements also performs well real world scenes fixed moving stereo cameras respectively particular extreme conditions real stereo visions additionally proposed jmss method implemented real time superior state art methods time efficiency also important consideration algorithm design society photo optical instrumentation engineers spie
paper suspension gravity compensation system sgcs modeled corresponding controller designed system servo platform consisting three sub systems micro gravity environment established especially novel zero stiffness suspension sub system creative unconstrained structure proposed system model deduced based lagrange equation pid controller designed using feedback linearization approach simulation results show effectiveness proposed method
paper discusses factors affect longevity durability induction motor various topics include overall construction induction machine major components field operating conditions motor vibration operating temperatures installation practice proper motor selection special environment application conditions sound machine design proper selection motor suit application proper field installation good maintenance key factors essential long term motor reliability performance
jensen weibel vitus article critically discusses contemporary danish policies aimed elimination ethnoracial discrimination drawing policy analyses qualitative interviews local national authorities denmark illustrates questions discrimination racism marginalized legitimized within dominant integration discourse resulting marginalization anti racism policymaking side stepping racism naturalized public policies strategies denial addressing discrimination product ignorance individual prejudice rather embedded social structures authors examine immigration integration anti racism concepts phenomena understood addressed danish public policies discourses despite denials racism denmark jensen weibel vitus show based definitions identities relations continues exist evident public debates policies immigration integration
sexual assault child profound impact child closest research examined ways women react cope sexual assault child within framework role mothers able mother aftermath assault total mothers child sexually assaulted interviewed across state illinois experiences women presented discussed within feminist literature regarding societal role mother
fatty acid synthase fasn key lipogenic enzyme novo fatty acid biosynthesis druggable metabolic oncoprotein activated human cancers evaluated whether driven lipogenic phenotype might represent biomarker sensitivity pharmacological fasn blockade majority clinically positive tumors scored fasn overexpressors series almost patients invasive breast carcinoma reclassification positive breast tumors based fasn gene expression predicted significantly inferior relapse free distant metastasis free survival fasn patients notably non tumorigenic mcfa breast epithelial cells engineered overexpress upregulated fasn gene expression fasn inhibitor abolished induced anchorage independent growth survival furthermore presence high concentrations negative mcf breast cancer cells overexpressing mcf significantly higher levels apoptosis negative cells finally non cytotoxic concentrations significantly reduced capacity mcf cells form mammospheres vitro indicator cancer stem like cells collectively findings strongly suggest fasn lipogenic axis delineates group breast cancer patients might benefit treatment therapeutic regimens containing fasn inhibitors
context debate exists overactive bladder oab treatment response assessment clinical trials nature shortcomings different endpoints used oab clinical research objective evaluate current evidence tools measure oab treatment response clinical trials inform development new multidimensional patient reported outcome pro could used primary endpoint oab trials evidence acquisition conducted narrative review oab literature available pubmed database published january june eighty articles selected full text review evidence synthesis assessment treatment outcomes oab challenging due heterogeneity symptoms reliance pros oab studies report high level placebo effect placebo response poorly understood found significant correlations pro measures bladder diaries evidence several issues bladder diary burden underestimation recall period lack validation trials conditions interstitial cystitis benign prostatic hyperplasia headache restless legs syndrome used symptom scales rather diaries measure treatment outcomes incorporate pro measures primary coprimary secondary endpoints international consultation incontinence research society recommends evaluation satisfaction symptoms health related quality life adverse events conclusions strong evidence shortcomings current approaches measuring oab outcomes clinical trials recognition new simpler approach incorporates symptom health related quality life assessment could provide comprehensive standardized approach oab assessment patient summary overactive bladder urinary syndrome individuals experience different symptoms varying degrees poses difficulties accurately measuring effect treatment review found evidence recommendations propose simpler comprehensive way measure treatment outcomes european association urology published elsevier rights reserved
effective seal breaching major contributor methane seepage deep sea sediments ensures migration gas liquid hydrocarbons buried reservoirs seafloor study shows two giant pockmarks lower slope lower congo basin associated salt tectonic faulting buried pliocene congo deep sea fan progressive burial pliocene fan deposits results mobilization methane gas hydrates base gas hydrate stability zone migrates hemipelagic seal towards seafloor along salt induced faults seal breaching part lower congo basin relies solely salt tectonic faulting contrasting upslope seafloor seepage settings polygonal faulting within hemipelagic seal occurs dedicated seismic acoustic surveying allows detailed reconstruction evolution pockmarks appear active last kyr also show indications modern seafloor depression formed due reduced sedimentation vicinity active seepage presented seafloor seepage features illustrate mode gas release pliocene fan lower congo basin contrasts previously investigated seepage environments upslope elsevier ltd rights reserved
american united states paradigm modernization development within context cold war birth control programs adapted chilean realities programs sought diminish high rates infant maternal mortality also responded american project hemispherical security designed contain potential popular revolutions third world countries
objectives impact wearing lenses visual musculoskeletal complaints vdu workers currently unknown goal study evaluate impact wearing vdu lenses visual fatigue self reported neck pain disability compared progressive lenses measure effect lenses head inclination pressure pain thresholds performance vdu task methods thirty five eligible subjects randomly assigned wear progressive vdu lenses vdu group progressive lenses group enquired visual complaints vfq self perceived pain nrs disability ndi baseline old lenses week months months wearing new lenses addition forward head angle fha ppts assessed vdu task months wearing new lenses short questionnaire concerning satisfaction study lenses completed end study results groups visual fatigue neck pain decreased months follow compared baseline ppts higher second vdu task independent type lenses vdu group reported significantly higher suitability lenses vdu work conclusion concluded little difference effect different lenses visual musculoskeletal comfort lenses adjusted task specific needs habits participant
paper explores large signal small signal dynamics series capacitor buck type converter introduces optimal closed loop control scheme accommodate steady state transient modes opposed conventional buck converter time optimal control realized single cycle buck topology need distribute switching phases satisfy charge balance flying capacitor new control method hybrids voltage mode small signal controller steady state operation non linear state plane based transient mode control scheme load transients detailed principle operation buck converter provided explained average behavioral model state plane analysis operation controller experimentally verified converter demonstrating voltage mode control operation well time optimal response load transients
solving resource constrained project scheduling problems one important tasks project planning process study presents new hybrid approach named artificial bee colony differential evolution handle resource constrained problems abcde proposed algorithm integrates crossover operations differential evolution original artificial bee colony abc balance exploration exploitation phases optimization process furthermore study applies serial method reflect individual vector priorities active schedule calculate project duration abcde algorithm compared benchmark algorithms considered using real construction case study set standard problem available literature experimental results demonstrate efficiency effectiveness proposed model abcde promising alternative approach handling resource constrained project scheduling problems
objective evaluate effectiveness treatment delivered via real time telerehabilitation management musculoskeletal conditions determine real time telerehabilitation comparable conventional methods delivery within population data sources six databases medline embase cochrane central pedro psycinfo cinahl searched inception november literature reported outcomes real time telerehabilitation musculoskeletal conditions review methods two reviewers screened abstracts studies met eligibility criteria methodological quality assessed using downs black checklist measuring quality tool results pooled meta analysis based upon primary outcome measures reported standardised mean differences confidence intervals results aggregate results suggest telerehabilitation effective improvement physical function smd whilst slightly favourable smd control cohort following intervention sub group analyses reveals telerehabilitation addition usual care favourable smd usual care alone whilst treatment delivered solely via telerehabilitation equivalent face face intervention smd improvement physical function improvement pain also seen comparable cohorts smd following intervention conclusions real time telerehabilitation appears effective comparable conventional methods healthcare delivery improvement physical function pain variety musculoskeletal conditions
study examined effects acculturation anxiety stress latino non latino white parents children undergoing outpatient surgery participants included parent child dyads four major children hospitals united states latino parents grew reported higher levels anxiety stress compared parents grew latin american country additionally english speaking latino parents reported higher anxiety stress compared spanish speaking latino non latino white parents whereas spanish speaking latino non latino white parents reported similar levels stress anxiety results current study consistent immigrant health paradox acculturated latino parents reported higher levels anxiety stress less acculturated latino non latino white parents supporting need culturally tailored interventions perioperative environment
objective summarise research evidence impact father infant skin skin contact infant paternal outcomes design integrative literature review data sources pubmed sciencedirect psycinfo cumulative index nursing allied health review methods studies included published english january september primary researches focused fathers providing skin skin contact infants impact infant paternal outcomes joanna briggs institute critical appraisal checklists used appraise scientific rigour studies findings twelve studies quantitative two qualitative included review father infant skin skin contact positive impacts infants outcomes including temperature pain biophysiological markers behavioural response well paternal outcomes include parental role attainment paternal interaction behaviour paternal stress anxiety conclusions father involvement providing skin skin contact seems feasible beneficial infants fathers however scarcity literature exclusively examines fathers involvement perceptions related skin skin contact postpartum period future research examine skin skin contact fathers associated benefits well fathers perceptions father infant ssc among varied populations implications practice father involvement providing skin skin contact promoted postnatal period father infant skin skin contact valuable alternative especially unavailability mothers due special circumstances including medical emergencies caesarean section elsevier ltd rights reserved
compare extent properties simple liquids pertinent short moderate chain alkanes ranging ethane dodecane explicit geometric features bonds angles dihedral potentials currently available models alkanes make systems realistic distinct generalized lennard jones chain fluids study confirms presence flexible geometric constraints completely suppresses energy virial correlation systems however found strong energy virial correlation high density region phase diagram contribution geometric constraints excluded fluids simple liquid like behavior semi quantitative relationships structure dynamics thermodynamics well established range state points explored test applicability relationships alkanes considering collection monomer beads reference state thermodynamic structural entropic measures systematically compared without intramolecular contributions show pair entropy computed explicit intramolecular geometric constraints correlates well thermodynamic excess entropy thermodynamic pair entropy strong isochore dependence reduced diffusivity intermolecular pair entropy correlates well reduced diffusivity role multiparticle correlations highlighted predicting thermodynamic transport properties chain systems triplet correlations addition pair correlations used attempt improve structural contribution excess entropy show three particle contribution included computation structural entropy resulting value overestimates excess entropy elsevier rights reserved
computational techniques tools developed understand hydrogen embrittlement hydrogen induced intergranular cracking based grain boundary engineering help computational materials engineering study help optimize misorientation configurations identifying cases would improve material properties increasing resistance hydrogen embrittlement order understand optimize important understand influence misorientation angle atomic clustered hydrogen distribution impact dilatational stress distributions study number crystal models tilt grain boundary tgb misorientation angles theta ranging degrees theta degrees developed rotation performed axis using numerical microstructural finite element analysis subsequently local stress strain concentrations generated along tgb due difference individual neighbouring crystals elastic anisotropy response functions misorientation angles evaluated crystals subjected overall uniform applied traction finally hydrogen distribution segregations function misorientation angles studied real nickel opposed numerical model geometrically necessary dislocations generated due misorientation generated dislocation motion along tgbs response dilatational mismatch varies depending misorientation angles generated dislocation motions affect stress strain hydrogen distribution hydrogen segregates along dislocations acting traps since dislocation distribution varies depending misorientation angles hydrogen traps also influenced misorientation angles results numerical modelling observed local stress strain hydrogen distributions inhomogeneous affected misorientation angles orientations neighbouring crystal boundary conditions real material opposed numerical model clustered atomic hydrogens segregated traps near tgb due influence dislocations developed effects applied mechanical stress numerical model predicts maximum hydrogen concentrations accumulated tgb misorientation angles ranging degrees theta degrees investigation reinforces importance engineering designing optimizing materials decrease hydrogen segregation arising tgb misorientation angles copyright hydrogen energy publications llc published elsevier ltd rights reserved
fusarium culmorum able cause devastating crown rot disease particularly barley wheat worldwide aim study investigate early physiological molecular changes barley roots response culmorum infection therefore infected day old barley roots highly pathogenic culmorum isolate root length shoot length significantly reduced days infection six widely cultivated turkish barley cultivars based disease index values marta six rowed tokak two rowed selected defense response comparatively assessed measures including production induction stress induced genes six time points infection fungal infection affect membrane integrity root cells osmolality decreased production increased molecular level antioxidant related genes hvcu znsod hvgst hvapx hvbas constitutively strongly expressed unlikely hvcat transcript accumulation slightly detected upon infection differential expression hvmt hvlox hvwrky observed following infection importantly pathogenesis related genes hvpr hvpr hvpr hvpr hvpr induced different time points infection transcript accumulation hvpr highest hvpr expressed minimal levels results showed unexpected cellular responses disruption osmotic adjustment barley roots role genes initial response culmorum attack
quantification interfacial interaction randomly rough surface prerequisite quantitatively understand control interface behaviors adhesion flocculation membrane fouling study found membrane surface randomly rough obvious fractal characteristics randomly rough surface membrane could well reconstructed fractal geometry represented modified weierstrass mandelbrot function novel method combined composite simpson approach surface element integration method approximation computer programming developed using method study provided first realization quantifying interfacial energy randomly rough surface membrane foulant particle calculated interactions randomly rough surface membrane significantly different smooth surface membrane indicating significant effect surface topography interactions proposed method could also potentially used investigate various natural interface environmental phenomena elsevier ltd rights reserved
diabetes mellitus metabolic disorder due irregularities glucose metabolism result insulin disregulation chronic type treated daily insulin injections subcutaneous route daily injections cause serious patient non compliance medication non adherence insulin depots parenteral formulations designed release insulin specified period time control plasma blood glucose level intended duration physiologically pancreas produces secretes insulin basal pulsatile mode blood delivery systems mimicking basal release profiles known open loop systems current marketed products open loop systems future trend open loop systems reduce number injections per week enhancing duration action modifying depot properties next generation technologies closed loop systems mimic pulsatile mode delivery pancreas closed loop systems insulin released response plasma glucose review focuses future trend open loop systems understanding secretion insulin pancreas insulin regulation normal insulin depots recent progress open loop depot technology particularly respect nanosystems elsevier rights reserved
introduction medicaid agencies promoting patient centered medical home pcmh model care givers choose physician practices children hypothesized following healthier childrearing practices likely seek care pcmh method selected children public insurance plans national survey children health used generalized ordinal logistic regression state fixed effects assess association home environments children use pcmhs results children living healthiest homes times likely receive care highest level pcmh states early pcmh implementation odds increased times discussion results show significant sizeable relationship healthier home environments use pcmh children low income families provide implications assessing effect pcmh use health outcomes use patterns
anomaly detection playing increasingly important role network security ability detect process anomalies big data real time difficult task conditions paper presents model combine cloud computing machine learning hadoop widely used open source cloud computing framework big data traffic data stored hdfs processed mapreduce besides machine learning module selected best performance algorithm multiple algorithms called weka interface moreover naive bayes decision tree svm used validate accuracy efficiency finally experimental results demonstrate method good performance detection accuracy
introduction nurse patient communication highly important especially patient child one thing overlooked nursing profession less discussed communicate children design training courses development communication skills considered important step direction study investigated effect training communication skills children nurses role playing materials methods study clinical trial pre test post test done nurses sheikh hospital mashhad iran nurses randomly assigned either intervention control groups nurses communication skills measured using tools calgary cambridge communication skills assessment three weeks intervention one day workshops hours teaching communication skills children given nurses role playing based pre prepared scenarios results results showed significant difference two groups mean score nurses verbal non verbal communication skills intervention verbal non verbal intervention mean score nurses verbal nonverbal communication skills experimental group statistically significant higher control group conclusion due weakness relationship nurse child bedside nurses also receive instruction communication specific skills related children seems essential effect implementation various educational practices examined nurses communication skills
role teachers safeguarding welfare children long acknowledged however recent research ireland found training provided teachers child protection issues lacking buckley mcgarry frequent interactions teachers children expertise terms typical child development place ideal position identifying possible signs abuse yet despite advantage research indicates schools fail report substantial proportion suspected child abuse cases kenny oft cited reasons may conceptualised explicit reasons lack knowledge child abuse issues implicit reasons individual teacher belief system abuse current paper discusses implicit well explicit obstacles teachers engagement consequent barriers responding child protection issues current changes initial teacher education introduction mandatory reporting professionals ireland offer opportune time raise issue highlight need holistic education child protection teachers copyright john wiley sons ltd
current study examined parent heart rate dynamic changing patterns links observed negative parenting emotional unavailability psychological control parent child conflict resolution task among parent child dyads child age ranged years age parent obtained electrocardiogram ecg data collected parent child conflict resolution task negative parenting coded offline based video recording task results revealed emotionally sensitive parents task showed greater increases discussing conflict greater decreases resolving conflict whereas emotionally unavailable parents showed changes however parent psychological control associated dynamics task findings indicated physiological underpinnings parent emotional sensitivity responsiveness parent child interactions potential association baseline levels parenting behaviors also discussed
autism spectrum disorder asd often accompanied gastrointestinal disturbances also may impact behavior alterations autonomic nervous system functioning also frequently observed asd relationship findings asd known examined relationship gastrointestinal symptomatology examining upper lower gastrointestinal tract symptomatology separately autonomic nervous system functioning assessed heart rate variability skin conductance level sample individuals asd relationships occurring medical psychiatric symptoms also examined number participants significant upper gastrointestinal tract problems small sample participants met criteria functional constipation disorder lower gastrointestinal tract heart rate variability measure parasympathetic modulation cardiac activity found positively associated lower gastrointestinal tract symptomatology baseline relationship particularly strong participants occurring diagnoses anxiety disorder history regressive asd loss previously acquired skills findings suggest autonomic function gastrointestinal problems intertwined children asd although possible assess causality data set future work examine impact treatment gastrointestinal problems autonomic function anxiety well impact anxiety treatment gastrointestinal problems clinicians aware gastrointestinal problems anxiety autonomic dysfunction may cluster children asd addressed multidisciplinary treatment plan autism res international society autism research wiley periodicals inc
current adjunctive psychosocial interventions bipolar disorder aim impact illness course via information sharing skill development focus clinical outcomes contrasts emergent recovery paradigm prioritises adaptation serious mental illness movement towards personally meaningful goals aim review encourage innovation psychological management considering three recovery oriented trends literature first importance quality life target recovery oriented clinical work considered second recent staging approach described outline implications psychosocial interventions tailored stage finally review evidence suggesting mindfulness based psycho social interventions potential across early middle late stages concluded humanistic emphasis recovery paradigm provides timely stimulus development next generation psycho social treatments people elsevier ltd rights reserved
degrees beam splitting mirror plays vital role image quality holographic system order study influence environment temperature variation degrees beam splitting mirror holographic system finite element analysis method used simulate anti three seven mirror deformation degrees degrees degrees temperature theory new real time monitoring displaying photoelectric system ambient temperature beam splitting mirror distortion detection designed provide real time temperature change deformation detection made laser speckle interferometer chip temperature sensor two operational amplifier mcu led indicator plane displacement value measured experiment condition temperature correspondingly finally relation equation temperature mirror deformation established method exponential equation fitting provide preliminary theoretical experimental reference research
powerful nonparametric bayesian model infinite mixture model successfully used machine learning computer vision success nite mixture model owes capability clustering density estimation paper propose nonparametric bayesian model single image super resolution specifically combine dirichlet process gaussian process regression estimating distribution training patches modeling relationship low resolution high resolution patches proposed method groups training patches utilizing clustering property dirichlet process proposed method relates low resolution highresolution patches predicting property gaussian process mentioned two points independent jointly learned hence proposed method make full use nonparametric bayesian model first dirichlet process mixture model used obtain accurate clusters training patches second gaussian process regression established cluster directly reduces computational complexity finally two procedures learned simultaneously gain suitable clusters ability prediction parameters inferred simply via gibbs sampling technique thorough super resolution experiments various images demonstrate proposed method superior state art methods
young children negotiate conflicts peers result mutually beneficial resolution peaceful interaction conflict studies suggest children use conciliatory strategies conflict socially adaptive outcomes likely achieved present study explores relative associations types children conciliatory conflict resolution strategies prosocial compliance oriented solution oriented verbal clarification apology conflict outcomes contribute knowledge discrete behaviors might salience conflict resolution training socially adaptive conflict outcomes expected strongly relate children resolution strategies prosocial nature well teacher peer interventions encouraging prosocial behavior empathy sampled conflicts collected field observations ethnically racially socioeconomically diverse four seven year old children logistic regression analyses bootstrap based inference suggested children prosocial behaviors conflict strongly tied mutually beneficial resolution peaceful postconflict interaction controlling relevant covariates conciliatory strategies varied association socially adaptive outcomes hypothesis regarding third party interventions encouraging prosociability empathy could examined due infrequent occurrence insights future research children socially adaptive conflict negotiations discussed
order solve problem designing specific paths air rail network according research method hub median problem hub spoke network mixed integer programming model established direct flight permitted model minimum total transportation cost objective function model solved using shortest path algorithm based traversal search method finally sample cities selected applied model algorithm optimized objective value specific paths calculated different variable parameters air rail network china fourteen cities constructed result shows close relationship among minimum total transportation cost number specific paths number hubs discount factor rho bigger value smaller value rho smaller total transportation cost specific paths vice versa
cerebral palsy common childhood disability worldwide yet biomarkers predicting lacking subjecting peripheral blood samples patients healthy controls affymetrix genechip primeview humangene expression microarray analysis identified novel biomarker cell lymphoma bcl upregulated gene samples gastrodin traditional chinese medicine bioactive compound promotes adductor angle release well gross fine motor performance increasing gross motor function measure fine motor function measure scores gastrodin upregulates mrna expression mgl mrc macrophage markers arginase activity polarization indicator murine raw macrophages moreover effects blocked bcl sirna also abrogated protective effects gastrodin hydrogen peroxide induced apoptosis death raw cells work identified bcl novel biomarker early prediction moreover demonstrated gastrodin stimulated polarization toward like macrophages promote tissue repair also rescued macrophages oxidative stress apoptosis death inducing bcl expression bcl targeted therapeutic strategies promise improving motor performance patients elsevier inc rights reserved
experimental operational modal analysis traditionally requires physically attached wired wireless sensors vibration measurement structures instrumentation result mass loading lightweight structures costly time consuming install maintain large civil structures especially long term applications structural health monitoring require significant maintenance cabling wired sensors periodic replacement energy supply wireless sensors moreover sensors typically placed limited number discrete locations providing low spatial sensing resolution hardly sufficient modal based damage localization model correlation updating larger scale structures non contact measurement methods scanning laser vibrometers provide high resolution sensing capacity without mass loading effect however make sequential measurements require considerable acquisition time alternative non contact method digital video cameras relatively low cost agile provide high spatial resolution simultaneous measurements combined vision based algorithms image correlation optical flow video camera based measurements successfully used vibration measurements subsequent modal analysis based techniques digital image correlation dic point tracking however typically require speckle pattern high contrast markers placed surface structures poses challenges measurement area large inaccessible work explores advanced computer vision video processing algorithms develop novel video measurement vision based operational output modal analysis method alleviate need structural surface preparation associated existing vision based methods implemented relatively efficient autonomous manner little user supervision calibration first multi scale image processing method applied frames video vibrating structure extract local pixel phases encode local structural vibration establishing full field spatiotemporal motion matrix high spatial dimensional yet low modal dimensional complete model used represent extracted full field motion matrix using modal superposition physically connected manipulated family unsupervised learning models techniques respectively thus proposed method able blindly extract modal frequencies damping ratios full field many points pixel number video frame mode shapes line sight video measurements structure method validated laboratory experiments bench scale building structure cantilever beam ability output video measurements identification visualization weakly excited mode demonstrated several issues implementation discussed published elsevier ltd
women less likely men engage sexually agentic behavior initiating sexual encounters despite benefits associated sexual agency kiefer sanchez two studies examined possible explanations related person perception gender differences sexually agentic behavior study participants viewed dating profiles targets either high low sexual agency rated sexually agentic targets desirable also riskier sexual partners previous sexual partners well selfish partners overall participants believed agentic female targets desirable also highest number previous sexual partners study female participants weighed importance consequences sexual agency differently male participants based two studies suggest although men women judged similarly sexual agency women may refrain sexual agency view traits characteristics perceived hand hand sexual agency negatively
foot ankle injuries second common reason young athletes present primary care physician account visits sports medicine clinics population heightened performance expectations placed today young athletes led intense training competition demands increasing rates sport participation among children adolescents important treating physicians understanding evaluation management ankle injuries seen pediatric athlete treating young athletes important keep mind unique developmental anatomic differences skeletally mature skeletally immature ankle differences predispose young athletes unique injuries seen adults include injuries result congenital developmental variations acute injuries overuse type injuries
software integration testing plays increasingly important role software industry experienced major change isolated applications highly distributed computing environments conducting integration testing challenging task often difficult replicate real enterprise environment emulating testing environment one key solutions problem however existing specification based emulation techniques require manual coding message processing engines therefore incurring high development cost paper present suite domain specific visual modeling languages describe emulated testing environments high abstraction level solution allows domain experts model testing environment abstract interface layers layer models transformed runtime environment application testing user study shows visual languages easy use yet sufficient expressive power model complex testing applications
although young adult women consume majority total daily energy intake home food sources decision making processes shape home food environments received limited attention decision making may affected transformative experience motherhood unknown study explore factors influence two key decision making processes food choices grocery shopping use non home food sources whether differences motherhood status depth interviews conducted women aged living southwest georgia thematic analysis used analyze qualitative data stratified whether children present home decision making affected numerous factors differed across groups regard grocery shopping women children frequently discussed influence nutrition preferences children women without children frequently discussed influence taste preferences household members cost convenience weight control pre planning meals emerged salient groups regard use non home food sources convenience taste discussed groups social factors discussed women without children cost eating reason cited eating inside home factor emerged among women children motherhood may important contributor decision making processes shape young adult women home food environments interventions may find success framing messaging emphasize factors identified motivating healthy decisions protecting health children practical strategies may adapted already use pre planning budgeting healthy meals elsevier ltd rights reserved
backgroundirritability frequent complaint children psychiatric disorders reflects increased predisposition anger preliminary work pediatric clinical samples links irritability attention bias threat current study examines association large population based sample methodswe studied children ages using development well assessment dawba childhood behavior checklist cbcl dot probe tasks irritability defined using cbcl items assessed temper tantrums hot temper dot probe task assessed attention biases threat related angry face stimuli multiple regression analysis used assess specificity associations irritability adjusting demographic variables occurring psychiatric traits propensity score matching analysis used increase causal inference matching demographic variables occurring psychiatric traits resultsirritability associated increased attention bias toward threat related cues multiple regression analysis suggests associations irritability threat bias independent demographic variables anxiety externalizing traits attention deficit hyperactivity conduct headstrong hurtful broad internalizing symptoms propensity score matching analysis indicated association found irritable versus nonirritable groups matched demographic occurring traits including internalizing symptoms conclusionsirritability children associated biased attention toward threatening information finding replicated warrants investigation examine extent contributes chronic irritability explore possible treatment implications
objectivethe efficacy mogamulizumab adult cell leukemia lymphoma atll reported previous phase study compared patients clinical trials however patients real life settings demonstrated worse outcomes methodwe retrospectively analyzed patients relapsed refractory atll received mogamulizumab treatment resultsrelapsed refractory atll patients median age years received median five courses mogamulizumab hematologic toxicity skin rash common adverse events manageable patients evaluable efficacy overall response rate median progression free survival pfs overall survival start mogamulizumab therapy months respectively original patients fulfilled inclusion criteria phase study met criteria demonstrated longer median pfs durations months respectively median diagnosis relapsed refractory atll patients receiving mogamulizumab months longer months historical cohort without mogamulizumab conclusionin clinical practice mogamulizumab exhibited antitumor activity patients relapsed refractory atll acceptable toxicity profile mogamulizumab therapy improved atll patients
background elevated blood pressure one main risk factors death globally behavioral neurocardiac training bnt complementary approach blood pressure stress management intended exercise autonomic reflexes improve stress recovery lower blood pressure bnt involves cognitive behavioral therapy paced breathing technique heart rate variability biofeedback bnt limited clinic delivery faces accessibility barrier need clinical oversight use complex monitoring tools objective objective project design develop evaluate wearable electrocardiographic ecg sensor system delivery bnt home setting methods wearable sensor system beat consists ecg sensor mobile app developed iteratively using principles test driven agile development user centered design usability study conducted toronto general hospital evaluate feasibility user experience identify areas improvement results beat sensor designed modular patch worn user chest uses standard ecg electrodes streams single lead ecg wirelessly mobile phone using bluetooth low energy use small low power electronics low device profile tapered enclosure allowed device unobtrusively worn clothing sensor designed operate mobile app guides users bnt exercises train slow paced breathing technique stress recovery bnt app uses ecg captured sensor provide heart rate variability biofeedback form real time heart rate waveform complement reinforce impact training usability testing indicated overall response design user experience system perceived positively participants indicated system positive effect stress management would use home areas improvement identified focused primarily delivery training education bnt app conclusions outcome project wearable sensor system deliver bnt home system potential offer complementary approach blood pressure stress management home reduce current accessibility barriers
objective describe rates patterns causes acute injuries increasingly popular outdoor sport design prospective cohort study setting one winter season ranging november march participants seventy ice climbers different countries various performance levels main outcome measures participants asked complete monthly internet based survey regarding completed hours training competitions eventual sustained injuries results hours ice climbing injuries occurred defined mild moderate severe calculated injury rate injuries per hours sports exposure intermediate ice climbers significantly higher injury risk compared advanced ice climbers odds ratio confidence intervals injuries occurred frozen waterfall icicles icefalls whereas occurred artificial ice walls head injured body part followed knee shoulder common types injuries abrasions contusions joint sprains falling ice main circumstance leading injury athletes head injury wore helmet however mentioned used protective goggles conclusion ice climbing sport moderate risk injury reported injuries minor severity however severe fatal injuries although less common also occur advanced ice climbers greater experience skill level lower overall injury risk
present work undertaken buffalo embryos fetuses starting days days study development different bones forming membranous viscerocranium ossification skull first appeared mandible maxilla malar days early ossification lacrimal squamous temporal tympanic ring evident days ossification palatine first observed days premaxilla vomer showed ossification days early ossification nasal bone observed days vomer contact floor nasal cavity throughout separating two posterior nares completely
background aim long term success rehabilitation chronic low back pain yet established present study examined promoting factors barriers barrier management health promoting behavior among rehabilitative patients method total documents patients inpatient behavioral medicine orthopedic rehabilitation clinics included analysis written survey based open questions free worded statements electronically recorded analyzed content analysis results promoting factors patients implementation healthy life style behaviors included learning techniques pain stress management well increased volition quality life among patients increased depressive symptoms insufficient volition family professional pressures identified barriers finally social support reported facilitate implementing health promoting behavior daily life conclusions results suggest long term rehabilitation success improved treating exercises implement health promoting behavior daily life applying individualized barrier management offering post rehabilitative treatments communities
mild traumatic brain injury mtbi common injury service members recent military conflicts insufficient evidence best treat consequences mtbi randomized clinical trial evaluated efficacy telephone delivered problem solving treatment pst psychological physical symptoms post deployment active duty service members joint base lewis mcchord washington fort bragg north carolina members medically confirmed mtbi sustained deployment iraq afghanistan within previous months received pst education interventions pst group received biweekly telephone calls counselor subject selected problems groups received educational brochures describing common mtbi post deployment problems follow months end pst months months pst group significantly improved measure psychological distress brief symptom inventory bsi compared group post concussion symptoms rivermead post concussion symptoms questionnaire rpq two primary endpoints however effects persist month follow bsi rpq pst group also significant short term improvement secondary endpoints including sleep depression post traumatic stress disorder physical functioning participants preferred pst overeo telephone delivered pst appears well accepted treatment offers promise reducing psychological distress combat related mtbi could useful adjunct treatment post mtbi studies required determine sustain effects trial registration clinicaltrials gov identifier nct https clinicaltrials gov
background voriconazole vrz triazole antifungal used treatment invasive fungal infection life threatening condition therapeutic drug monitoring recommended identifying optimal dose patients hepatic renal impairment reduced function cypc metabolizing enzyme methods one hundred microliters sample plasma extracted protein precipitated acetonitrile containing fluconazole internal standard vortexing centrifugation supernatant dried reconstituted mobile phase acn formic acid ammonium acetate injected column flow rate min retention time min vrz respectively tandem mass spectrometer set multiple reactions monitoring mrm mode following transition vrz results accuracy precision inter intra day less range linearity consistent recovery analyses conclusion method applicable routine monitoring patients vrz plasma level fast accurate runtime assess cypc genotype wiley periodicals inc
framework agreements emerging construction management tool used public authorities achieve value money vfm services research aims assess whether use framework agreements highways maintenance projects result significant improvement performance outcomes production transaction costs construction phase single case study conducted investigate outcomes set within context major county council independent samples tests framework traditional discrete projects proved significant improvements performance outcomes time finish time cost payment accuracy quality defects health safety resulted framework agreements independent samples tests also identified significant improvements total cost engagement performance monitoring without significant changes tender prices conclusions study support use framework procurement local authority public sector clients highways maintenance leading significant improvements performance outcomes cost savings hence vfm services achieve optimal use resources based case study findings informed policy decision made county council adjacent local authorities implement expanded framework agreement cover south east region
increasing penetration distributed resources regulators electricity distribution utilities face greater uncertainty regarding evolution network uses efficient system costs uncertainty threaten revenue adequacy challenges cost service rate return incentive performance based approaches remuneration distribution utilities address challenges paper proposes novel methodology establish allowed utility revenues multi year regulatory period method combines several state art regulatory tools designed overcome information asymmetries manage uncertainty align incentives utilities cost effectively integrate distributed energy resources taking advantage opportunities reduce system costs improve performance use reference network model simulate large scale urban distribution network demonstrate practical application regulatory method illustrate performance face benchmark forecast errors
study examines utility checklists attaining accurate diagnoses context diagnostic decision making mental disorders study also aimed replicate results meta analysis indicating association patients gender misdiagnoses end psychotherapists asked judge three case vignettes describing patients major depressive disorder mdd generalized anxiety disorder borderline personality disorder therapists randomly assigned experimental conditions diagnostic method using diagnostic checklists without using diagnostic checklists gender male female case vignettes subjects design multinomial logistic linear regression analyses used examine association usage diagnostic checklists well patients gender diagnostic decisions results showed checklists used fewer incorrect morbid diagnoses made clinicians less likely diagnose mdd even criteria met additionally checklists improved therapists confidence diagnostic decisions associated estimations patients characteristics expected significant associations gender diagnostic decisions
new zealand earth system model nzesm currently development help inform scientists policy makers climate sensitive sectors economy general public new zealand climate change term climate model generally used describe computer model incorporates physical aspects climate system atmospheric oceanic fluid mechanics thermodynam ics addition earth system models represent aspects biology chemistry marine biogeochemistry atmospheric ozone chemistry development nzesm represents step change model complexity new zealand science major motivation development reduce southern hemisphere specific mod elling problems formation southern ocean sea ice antarctic bottom water atmosphere land surface ocean sea ice components model already available new zealand future additional models representing ample ocean biogeochemistry marine ice sheets also added nzesm framework next years nzesm run produce hindcasts past years projections years future experiments enable new zealanders adapt manage risk thrive changing climate mission statement deep south national science challenge next decade nzesm used earth system science research throughout new zealand terms pure science via communication results new zealanders
carthamus tinctorius safflower annual herbaceous crop belonging family asteraceae cultivated throughout china used traditional chinese medicine previous study revealed anti parkinson disease effects isolated standardized safflower flavonoid extract safe purpose study evaluate potential sub chronic toxicity safe male female sprague dawley rats received three doses safe gavage four weeks body weights measured experiment blood samples collected per week hematological serum biochemical parameters major organs examined execution histopathological analyses performed body weight gain administration groups showed decline compared control group however changes values aspartate transaminase alanine transaminase blood glucose treatments safe influenced parameters related platelets rats receiving safe sexes different dosages histopathological changes observed safe might influence conglomeration platelets transaminases blood glucose safe caused significant toxicity studies may needed ensure safety safe elsevier inc rights reserved
paper proposes approach forming average performance grey modeling use average performance reference model performing evolutionary computation error type control performance index idea approach construct reference model based performance unknown systems users apply evolutionary computation fine tune control systems error type performance index apply approach particle swarm optimization searching optimal gains baseline controller wind turbines operating certain set point region numerical simulation part corresponding results demonstrate effectiveness grey modeling elsevier ltd rights reserved
background objectives literature suggests imagery rescripting imrs effective psychological intervention methods conducted meta analysis imrs psychological complaints associated aversive memories relevant publications collected databases medline psychlnfo web science results search identified trials including seven randomized controlled trials adult patients posttraumatic stress disorder eight trials social anxiety disorder six trials body dysmorphic disorder two trials major depression one trial bulimia nervosa one trial obsessive compulsive disorder one trial imrs administered mean sessions range effect size estimates suggest imrs largely effective reducing symptoms pretreatment post treatment follow overall sample hedges respectively comparison imrs passive treatment conditions resulted large effect size posttreatment finally effects imrs comorbid depression aversive imagery encapsulated beliefs also large limitations analyses involved pre post comparisons findings limited small number randomized controlled trials conclusions findings indicate imrs promising intervention psychological complaints related aversive memories large effects obtained small number session elsevier ltd rights reserved
job assistance programs commonly recommended parents children victimized child maltreatment particularly illicit drugs indicated however relationship employment factors substance abuse risk child maltreatment received limited empirical attention therefore current study examines employment factors sample mothers referred child protective services treatment substance abuse child neglect child maltreatment potential found negatively associated number hours employed self reported happiness employment association child abuse potential personal income participants approached significance results influenced social desirability employment satisfaction significantly contributed prediction child maltreatment potential employment factors control variables findings suggest mothers involved child protective services risk perpetrating child maltreatment may reduced assisted gainful employment personally satisfying happiness employment employment factor correlated inversely substance use biological testing self report participants future directions discussed light results including importance considering employment satisfaction conducting vocational assistance programs population
purpose trajectory health related quality life hrqol children aged years relationship speech language difficulties sald examined using data longitudinal study australian children lsac method generalized linear latent mixed modelling used analyse data three waves lsac across four hrqol domains physical emotional social school functioning four domains hrqol measured using paediatric quality life inventory pedsql examined find contribution sald accounting child specific factors gender ethnicity temperament family characteristics social ecological considerations psychosocial stressors result multivariable analyses one measure sald namely parent concern receptive language negatively associated hrqol domains covariates positively associated hrqol domains included child general health maternal mental health parental warmth primary caregiver engagement labour force conclusion findings suggest sald associated reduced hrqol lsac study children typical speech language skills protective factor positively associated hrqol
introduction family carers people dementia important support practical personal economic terms carers vital maintaining quality life qol people dementia review aims identify factors related qol family carers people dementia methods searches terms including carers dementia family quality life research databases findings synthesized inductively grouping factors associated carer qol themes results total abstracts identified following screening lateral searches quality appraisal studies included synthesis total themes identified demographics carer patient relationship dementia characteristics demands caring carer health carer emotional well support received carer independence carer self efficacy future discussion quality level evidence supporting theme varied need research factors predict carer qol dementia measure authors published elsevier inc behalf alzheimer association
research aims model interactive networks risks associated different stakeholders green building projects gain understanding key risk networks case studies green star accredited office building projects undertaken china australia case data collected focused group workshops face face interviews desktop studies analysed using social network analysis methods results show reputation risk important countries ethical risk assessment experience fairness highlighted crucial chinese context results show government plays important role improving societies knowledge awareness green technology uptake china social network analysis method research improves effectiveness accuracy stakeholder risk analysis demystifying social complexity usually overlooked traditional linear risk impact analysis elsevier ltd apm ipma rights reserved
rendering textures real time environments key task computer graphics paper presents new parallel patch based method allows repeatable sampling without cache create visual repetitions interchangeable patches arbitrary shape prepared preprocessing step patches may lie boundary patches repeating tile compresses example texture infinite texture map small memory requirements suitable gpu ray tracing applications quality textures rendered method tuned offline preprocessing step rendered times comparable wang tiles experimental results demonstrate combined benefits speed memory requirements quality randomisation compared previous methods
biomolecules well known complexation heavy metals wastewater cellulose alginate pectins starches example however less used natural molecules could also efficient chelate heavy metals indeed cells contain polypeptides help detoxifying living organisms containing heavy metals natural detoxification process great interest particularly molecules taking part amino acids composing polypeptides especially cysteine tyrosine histidine used water purification efficiency biomolecules containing aromatic rings heavy metals complexation also investigated biomolecules able chelate heavy metals thanks chemical groups atoms well known efficient chemical groups listed article finally potential environmental applications biomolecules suggested end article
icariin ica pharmacologically active flavonoid glycoside shows promise treatment prevention osteoporosis however mechanisms underlying anti osteoporotic effects ica remain largely unclear present study used quantitative polymerase chain reaction western blot immunohistochemical analysis examine effects ica several key targets notch signaling pathway bone tissue ovariectomized rats observed ica pronounced beneficial effect rats inhibits expression peroxisome proliferator activated receptor ppar ccaat enhancer binding protein ebp fatty acid binding protein fabp mrna addition identified ica downregulates expression notch intracellular domain nicd jagged proteins bone tissue suppresses effect nicd notch mrna expression proposed ica inhibits differentiation mesenchymal stem cells adipocytes inhibiting expression ppar ebp fabp mrna via notch signaling pathway addition proposed ica inhibits expression notch mrna suppressing effect nicd conclusion results provide mechanistic evidence clinical efficacy ica treatment
spray drying process widely applied food industry due reduced operation time low cost use probiotic bacteria non dairy products receiving much attention application dry food products alternative consumption thus aim study evaluate effect gum arabic maltodextrin gelatin survival lactobacillus reuteri fermented jucara pulp dehydration spray drying influence physical properties powders obtained therefrom spray dried powders produced using carrier agents analyses cell viability moisture content sorption isotherms solubility morphological characteristics colour conducted dehydration viability reuteri log cfu tested carriers powders produced gelatin presented higher bacterial survival drying log cfu higher yield solubility obtained gum arabic maltodextrin moisture content around results demonstrate gelatin promising material drying probiotic bacteria however technological properties powders need improved used dehydrated product elsevier ltd rights reserved
purpose leadership significant success factor promoting sustainability practices construction industry sustainability integral part construction industry affects aspects construction business operations purpose paper investigate particular leadership style associated intra organizational leaders within construction organizations charged promotion sustainability practices paper therefore examines effective leadership style sustainability professionals responsible developing sustainable construction strategies design methodology approach qualitative data collected semi structured interview leaders followed industry wide survey intra organizational leaders contractor consultant organizations construction industry findings results showed one best leadership style situation leaders charged role promoting sustainable construction strategic style behaviour originality value although leadership sustainability widely covered separate issues little rigorous research done link leadership sustainability construction management research findings could guide organizational leaders responsibility promoting sustainability practices
construction resources including materials labors equipment extremely cost extensive construction projects management resources complex process significantly affects construction costs quality time several factors identified literature contribute enhancing efficiency resources management life cycle buildings optimizing utilization resources factors referred critical success factors therefore required processes data identified order appropriately address factors commonly referred necessary procedures success procedures depend availability specific processes data essentially needed assessing efficiency resources management design construction operation maintenance buildings life cycle paper aims identifying necessary procedures terms required processes corresponding data associated help improving efficiency resources management research methodology adopted paper includes content analysis comparative analysis identify required processes corresponding data results presented paper include formulation matrix presents identified necessary procedures materials labors equipment related assessing efficiency resources management life cycle buildings matrix articulates nature type required processes corresponding data along specific stages buildings life cycle facilitate assessment resources management efficiency matrix introduces important tool designers managers construction projects utilized conducting assessment resources management efficiency
main objective study configure acquisition analysis low field magnetic resonance imaging mri predict physico chemical characteristics iberian loin evaluating use different mri sequences spin echo gradient echo turbo computational texture feature methods glcm ngldm glrlm glcm ngldm glrlm data mining techniques multiple linear regression mlr isotonic regression moderate good correlation coefficients low mean absolute error found applying mlr method computational texture features mri acquired sequence accurate results obtained applying glcm glcm ngldm glrlm methods considering accuracy methodology also consumed time required resources use sequences mri acquisition glcm method mri texture analysis mlr could indicated prediction physico chemical characteristics loin
diffuse panbronchiolitis dpb asthma obstructive airway diseases former characterized type latter thtype airway inflammation differential diagnosis often problem coexistence rarely reported year old man asthma admitted hospital one month history dyspnoea exertion bilateral diffuse granular shadows also history chronic sinusitis auscultation lungs showed coarse crackles wheezes laboratory data revealed elevated total serum immunoglobulin high titre cold agglutinin bronchoscopic evaluations shadows revealed compatible pathological findings dpb asthma low dose macrolide caused prompt reduction symptoms along improvements radiographic findings pulmonary functions whereas eosinophilic airway inflammation transiently worsened dpb asthma coexist balance immune response may reciprocally altered therapeutic intervention
interdisciplinary universe involves legal incentives sustainable urban construction architectural principles traditionally used construction research aims normative framework eleven municipalities americana campos jordao tiete araraquara barretos ipatinga guarulhos sao vicente goiania camboriu seropedica identify incentives regulated parameters sustainability contemplated research qualitative quantitative approach procedure data collection documentary research surveys found sustainability parameters present legal incentives natural lighting green roof rainwater harvesting solar heating system finally concluded importance legal incentives sustainable construction parameters entered architectural projects meet needs present generation without compromising ability future generations meet needs
paper presents current mode multifunction biquadratic filter multiple inputs multiple outputs using single modified current differencing transconductance amplifier two grounded capacitors proposed circuit provides following advantages low number active passive elements realization lowpass bandpass high pass bandstop allpass filtering functions employment grounded capacitors suitable integrated circuit implementation requirement component matching conditions inverting type input signals electronic control natural frequency low active passive sensitivities pspice simulation using standard cmos technology performed confirm workability proposed universal filter
new class electric airship globally transport passengers freight using feeder cruiser concept powered renewable electric energy considered specific focus given photo electric harvesting primary energy source associated hydrogen based energy storage systems furthermore shown total output may significantly increased utilising cloud albedo effects appropriate power architectures energy audits required life support propulsion ancillary loads support continuous daily operation primary airship cruiser stratospheric altitudes circa also considered presented solution substantially different conventional aircraft due airship size inherent requirement harvest store sufficient energy daylight operation subject varying seasonal conditions latitudes ensure safe continued operation corresponding varying dark hours particularly apparent sizing proposed electrolyser considered size mass increase nonlinearly decreasing day night duty unitized regenerative fuel cell proposed first time study also discusses potential benefits integrating photo voltaic cells airship canopy structures utilising tensairity based elements order eliminate requirements separate inter array wiring transport low pressure hydrogen fuel cells
background epidemiological evidence showing association periodontal disease cardiovascular disease cvd despite evidence star comprehensive review undertaken identify strategies improve oral health people cvd objectives aim review identify current evidence relating oral healthcare management patients cvd methods scoping review undertaken focusing key areas namely impact periodontal treatment cvd current recommendations regarding oral health cvd role nurses promoting oral health available resources support databases searched using combination keywords search terms articles selected results systematic reviews suggest periodontal treatment may improve cvd outcomes reducing systemic inflammation improving endothelial function however insufficient evidence confirm refute findings international guidelines recognize link periodontal disease cvd recommend preventative strategies area non oral health professionals including nurses promote oral health undertaking role areas like aged care pregnancy however aspect nursing care explored cardiac setting relevant training assessment tools available conclusions maintaining oral health among cardiovascular patients important yet appears neglected cardiac care cardiac nurses excellent position promote oral health research required define role develop supporting resources
authors synthesized counseling leadership literature identify themes counseling leadership using inductive approach content analysis authors analyzed empirical articles conceptual articles leadership profiles results yielded emergent leadership themes sorted groups findings pave way comprehensive research counseling leadership allow increased intentionality teaching training practicing counseling leadership
present study tested supposition greater levels couple identity ness increase woman coping self efficacy relation breast cancer turn predicts better psychosocial adjustment women committed relationships completed surveys assessing levels couple identity cancer coping self efficacy aspects psychosocial adjustment specifically depression anxiety functional well one outpatient visits cancer centre predicted women identified relationships lower levels depression anxiety greater functional well relationship mediated coping self efficacy greater identification one relationship predicted greater confidence one ability cope turn predicted better adjustment role intimate relationships play women adjustment breast cancer well directions research discussed
background rise social media proved fertile ground expansion acquired immune deficiency syndrome aids denialist movement form online communities substantial literature devoted disproving aids denialist views lack studies exploring aids denialists online communities interact external environment objective explored three research areas reasons newcomers come aids denialist community patterns interactions community newcomers rhetorical strategies denialists use persuasion veracity views methods studied largest aids denialist community one popular social networking services russia used netnography method collecting data qualitative analysis observed community months least times week netnography periodically downloaded community discussions total downloaded posts comments analysis grounded theory approach used data analysis results users came community following reasons stories fit unitary picture aids disease progression translated popular medical discourse health problems concern hiv positive tests desire dissuade community members false aids beliefs basis strength aids denialist beliefs constructed typology newcomers consisting three ideal typical groups convinced already become denialists coming group doubters undecided truth either human immunodeficiency virus hiv science theory aids denialist theory orthodox openly held hiv science views reception newcomer mainly depended newcomer belief status reception warm convinced cold slightly hostile doubters extremely hostile derisive orthodox identified seven main rhetorical strategies persuasion used denialists undecided conclusions contrary widespread public health depiction aids denialists totally irrational study suggests become aids denialists sufficiently reasonable grounds suspect something wrong scientific theory personal experience contradicts unitary picture aids disease progression odd inexplicable practices aids centers fuel people suspicions conclude public health practitioners practices may play role generating aids denialist sentiments interactions newcomers experienced community members highlighted importance personal autonomy freedom choice decision making consistent consumerist ideology health care study findings suggest health care workers change one size fits mode counseling complex patient tailored approach allowing diversity disease progression scenarios scientific uncertainty
paper unified algebraic transformation approach presented designing parallel recursive adaptive digital filters singular value decomposition svd algorithms approach based explorations algebraic properties target algorithms representations several typical modern digital signal processing examples presented illustrate applications technique include cascaded orthogonal recursive digital filter givens rotation based adaptive inverse algorithm channel equalization decomposition based svd algorithms three examples exhibit similar throughput constraints exist long feedback loops algorithms signal flow graph representation critical path proportional size problem applying proposed algebraic transformation techniques parallel architectures obtained three examples cascade orthogonal recursive filter retiming transformation orthogonal matrix decompositions pseudo commutativity applied obtain parallel filter architectures critical path five givens rotations adaptive inverse algorithm commutativity associativity matrix multiplications applied obtain parallel architectures critical path either four givens rotations three givens rotations plus two multiply add operations whichever turns larger svd algorithms retiming associativity matrix multiplications applied derive parallel architectures critical path eight givens rotations critical paths parallel architectures independent problem size compared proportional problem size original sequential algorithms parallelism achieved expense slight increase svd case algorithms computational complexity
solar selective coatings multi layered materials optimize solar absorption reducing thermal radiation losses granting material long term stability layers deposited structural materials stainless steel inconel order enhance optical thermal properties heat transfer system however interesting questions regarding mechanical stability arise operating high temperatures work full thermo mechanical multiscale methodology presented covering nano micro macroscopic scales methodology fundamental material properties determined means molecular dynamics simulations consequently implemented microstructural level means finite element analyses hand macroscale problem solved taking account effect microstructure via thermo mechanical homogenization representative volume element rve methodology presented herein successfully implemented reference problem concentrating solar power plants namely characterization carbon based nanocomposite obtained results agreement expected theoretical values demonstrating possible apply successfully concepts behind integrated computational materials engineering design new coatings complex realistic thermo mechanical applications
purpose studied sexual reproductive health among self identified bisexual lesbian heterosexual adolescent young women prior research suggested bisexual lesbian young women may greater risk many negative health outcomes including risky sexual reproductive health behavior methods using data nationally representative national survey family growth nsfg examined sexual reproductive health among young women years age function sexual orientation used logistic regression ancova examine differences sexual reproductive health across groups controlling demographic group differences results bisexual lesbian young women reported elevated sexual reproductive health risks bisexual lesbian participants reported younger heterosexual sexual debut male female sexual partners heterosexual participants likely heterosexual young women report forced sex male partner bisexual young women reported earliest sexual debut highest numbers male partners greatest use emergency contraception highest frequency pregnancy termination conclusions overall sexual minority young women especially identified bisexual higher sexual reproductive risk heterosexual peers society adolescent health medicine rights reserved
several studies suggested role bdnf development schizophrenia example post mortem studies shown significantly reduced levels bdnf protein expression brain schizophrenia patients investigated relationship reduced levels bdnf brain regulation prepulse inhibition ppi behavioral endophenotype schizophrenia used bdnf heterozygous mutant rats display decrease mature bdnf protein levels previously observed normal baseline ppi responses dopamine receptor agonist apomorphine rats focused effects nmda receptor antagonist interaction mglur mglur receptors ppi response serotonergic drugs administration caused dose dependent reduction ppi increase startle amplitudes baseline ppi effect significantly altered male female bdnf heterozygous rats although induced increase startle levels reduced treatment mglur agonist mglur antagonist mpep alter effect ppi controls bdnf mutant rats treatment serotonin receptor agonist dpat serotonin receptor agonist doi serotonin releaser fenfluramine induced differential effects ppi startle effects different genotypes results show significant decrease bdnf protein expression lead reduced ppi baseline changes regulation ppi via nmda receptors serotonergic mechanisms findings genetic rat model bdnf deficiency support role similar reductions bdnf levels schizophrenia disruption ppi widely reported endophenotype illness potential implications results understanding changes ppi bdnf expression schizophrenia discussed elsevier inc rights reserved
molecular characterization circulating tumor cells ctcs critical identify key drivers cancer metastasis devising therapeutic approaches particularly inflammatory breast cancer ibc usually diagnosed advance stages progresses rapidly genomic alterations tumor tissue samples studied using foundation one single ctcs isolated using cellsearch followed single cell isolation deparray samples ctcs chosen isolate single ctcs using deparray genomic alterations studied primary tumor metastatic sites ibc patients genes high frequency mutations follows pikca also erbb least treatment ctcs detected patients metastatic ibc two patients locally advanced ibc four patients detectable ctcs per blood fifteen patients ctcs six chosen random isolate single ctcs cells tested presence pikca erbb mutations previously found matching tissue biopsies isolated ctcs showed mutations primary metastatic tumor samples intra patient ctc heterogeneity found presence different ctc subclones ctcs harboring different combinations mutated wild type genes results indicate ctcs could represent non invasive source cancer cells determine genetic markers disease progresses identify potential therapeutic targets ibc patients
industry accreditation bodies around world require graduates able demonstrate specific graduate attributes universities century responded call embedding graduate attributes curricula however individual academics ensure incorporating assessing graduate attributes respective modules form part overall curriculum research question necessitates reflection many academics struggling come terms many graduate attributes really mean entail moreover dearth research publications exists trying define explain graduate attributes purpose article determine extent graduate attributes adopted central university technology embedded curriculum national diploma electrical engineering qualitative case study used data collected using documentary review study guides electrical engineering qualification analysed results study show graduate attributes spread across entire curriculum four dominate graduate attributes found innovation problem solving technical conceptual competence numeracy technological literacy certain graduate attributes clearly discerned learning outcomes others hidden different teaching learning activities key recommendation study academics structure learning outcomes way addresses incorporation assessment key graduate attributes required
optimal biogas system design model obsdm described paper intended used decision making tool increase awareness potential biogas technology different applications sub saharan africa ssa decision making tool identifies suitable biodigester design based user defined inputs including energy fertiliser requirements feedstock type amount rate supply water supply land use area soil type ground water level climate temperature rainfall construction materials available locally priorities based sustainability criteria intended biogas user output model provides recommended design estimates expected costs energy fertiliser production links contact biodigester suppliers order test model data household surveys conducted rural regions kenya cameroon used inputs model innovative fixed dome biodigester design uses stabilised soil blocks instead bricks identified optimal kenyan cameroonian rural households expected performance optimal biogas system design model output consistent survey data existing biogas systems region elsevier ltd rights reserved
background observational studies used measure effectiveness intervention non experimental real world scenarios population level recognised important component evidence pyramid data accrued prospective cohort studies patient registry proven method type study national hepatitis hcv registry established ireland aim monitoring clinical economic outcomes new high cost regimens treatment hcv infection sustained virological response svr weeks following completion therapy interferon containing regimens considered cure non randomisation studies result confounding selection bias propensity score matching one number statistical tools used mitigate effects confounding observational studies methods analysed data patients underwent triple therapy treatment telaprevir tpv combination pegylated interferon ribavirin boceprevir boc june december decision initiate treatment selection treatment regimen discretion physician adjust confounding three approaches propensity score matching assessed adjusted sustained virological response rates svr odds ratios values confidence intervals calculated three matched dataset results prior matching unadjusted sustained virological response rates weeks treatment complete svr telaprevir boceprevir respectively matching adjusted svr rates telaprevir boceprevir respectively conclusion efficacy rates comparable reported pivotal clinical trials real world studies adjusting confounding conclude difference treatment effect matching small sample size limits conclusions made effect matching propensity score adjustment remains tool applied future analysis however suggest possible using larger sample size order reduce uncertainty around outcomes
focus manuscript cognitive systems engineering ecological interface design cse eid role framework may play improving system safety first decision making problem solving literatures reviewed eye towards informational needs required support activities utility two rasmussen analytical tools abstraction aggregation hierarchies conducting work domain analyses identify associated information categories relationships discussed importance designing ecological displays interfaces span informational categories abstraction hierarchy described concrete examples provided potential role ecological interfaces play providing effective decision making preventing accidents problem solving dealing accidents support thereby improving safety socio technical systems explored elsevier ltd rights reserved
nonverbal communication also known body language important form communication nonverbal behaviors posture eye contact gestures send strong messages regard nonverbal communication eye contact one important forms individual use however lack eye contact occurs use video conferencing system disparity locations eyes camera gets way eye contact lock eye gazing give unapproachable unpleasant feeling paper proposed eye gazing correction video conferencing use two cameras installed top bottom television captured two images rendered warping virtual position implement view morphing detected face synthesize face warped image experimental results verify proposed system effective generating natural gaze corrected images
nowadays water energy consumption intensifying every year countries perpetual increase supportable long run making urgently manage resources sustainable way domestic consumptions water electric energy usually related important study relation identifying opportunities use efficient improvement fact without understanding water energy relations water efficiency measures may lead unintentional costs energy efficiency field order take full advantage combined effect water energy water management methodologies necessary collect data ensure efforts directed effective paths paper presents study based characterization measurement analysis water electricity consumption single family house months period order find interdependent relationship consumptions end user level study carried baths divided four different scenarios influence two variables tested flow reducer valve bath temperature data showed presence flow reducer valve decreased electric energy consumption water consumption increased bath duration setting lower temperature water heater decreased electric consumption water consumption bath duration analysing influence flow reducer valve degrees temperature simultaneously concluded significant influence electric energy consumption baths duration influence water consumption author published elsevier
well known use line partial discharge measurements indicator stator winding insulation condition scheduled measurements could used test evaluate quality equipment test results could help diagnose insulation problems motors generators corresponding action failure occurs although number measurement methods exists tests results operating rotating machines influenced conditions humidity temperature terminal voltage load paper describes development imitation mathematical model stator insulation experimental investigation physical model performed adequacy assessment capacitive sensor used online monitoring
solar driven water splitting promises step towards large scale solar energy storage however bottleneck always poor performance used photoanodes particularly capability harvest visible light herein report design visible light active anatase titanium dioxide nanocrystals sub size surface area similar using sol gel method followed hydrothermal treatment relatively low temperature degrees fabricated nanocrystals demonstrate band gap increased amount surface defects overcome negative effects bulk defects revealed positron annihilation measurements prepared nanocrystals notable enhancement solar light harvesting water splitting efficiency compared commercial degussa counterpart photoactivity structural electrochemical behavior synthesized nanocrystals investigated using ray diffraction xrd transmission electron microscopy tem photocurrent measurements photoluminescence ray photoelectron spectroscopy xps positron annihilation doppler broadening analysis elsevier ltd rights reserved
generalized estimating equations gee useful tools marginal regression analysis longitudinal data high number variables along presence missing data presents complex issues working longitudinal context variable selection instance penalized generalized estimating equations systematically developed integrate missing data pgee multiple imputation penalized generalized estimating equations extension multiple imputation least absolute shrinkage selection operator lasso presented pgee allows integration missing data within subject correlation variable selection procedures missing data dealt using multiple imputation variable selection performed using group lasso penalty estimated coefficients variable across multiply imputed datasets considered group applying penalized generalized estimating equations leading unique model across multiply imputed datasets order select tuning parameter new bic like criterion proposed simulation study advantage using pgee compared simple imputation pgee shown usefulness new method illustrated application subgroup placebo arm strontium ranelate efficacy knee osteoarthritis trial study elsevier rights reserved
objective objective article obtain detailed quantitative assessment cerebellar function structure unselected migraine patients controls general population methods total clinically well defined participants migraine aura migraine without aura non migraine controls age range female population based study subjected range sensitive validated cerebellar tests cover functions main parts cerebellar cortex including cere brocerebellum spinocerebellum vestibulocerebellum addition participants underwent magnetic resonance imaging mri brain screen cerebellar lesions positive control cerebellar tests conducted patients familial hemiplegic migraine type fhm age range female carrying cacnaa mutation known affect cerebellar function results mri revealed cerebellar ischemic lesions migraine patients controls always located posterior lobe except one control regard cerebellar tests differences migraine patients aura migraine patients without aura controls purdue peg board test fine motor skills assembly scores block design test visuospatial ability mean scaled scores iii prism adaptation task limb learning shift scores eyeblink conditioning task learning dependent timing peak time body sway test balance capabilities pitch velocity score two legs stance condition among migraine patients cerebellar ischaemic lesions performed worse without lesions assembly scores pegboard task primary outcome measures tasks compared controls non hemiplegic migraine patients fhm patients showed substantially deficits primary outcomes including purdue peg assembly block design scaled score shift prism adaptation peak time conditioned eyeblink responses pitch velocity score stance sway test conclusions unselected migraine patients general population show normal cerebellar functions despite increased prevalence ischaemic lesions cerebellar posterior lobe except impaired pegboard test revealing deficits fine motor skills lesions appear little functional impact contrast cerebellar functions significantly impaired participants fhm
objective schizophrenia associated increase risk homicide suicide objectives study systematically review published articles examined relation neurocognitive deficits suicidal homicidal behaviours schizophrenia identify vulnerabilities suicidal homicidal behaviour may share common pathway schizophrenia methods systematic review literature performed using medline include studies published august results among studies neuropsychological brain imaging studies met selection criteria included final analysis neuropsychological functional neuroimaging studies inconclusive structural imaging studies reported various alterations patients schizophrenia history homicidal behaviour including reduced inferior frontal temporal cortices increased mediodorsal white matter increased amygdala volumes patients history suicidal acts showed volumetric reductions left orbitofrontal superior temporal cortices right amygdala volume increased though findings rarely replicated finally study directly compared neurocognitive markers suicidal homicidal risk conclusion results suggest brain alterations addition associated schizophrenia may predispose patients higher risk homicide suicide particular circumstances moreover alterations may shared homicidal suicidal patients however owing several limitations including small number available studies firm conclusions drawn investigations necessary
crime major public health safety threat many studies suggested early exposure child maltreatment increases individual risk persistent serious crime adulthood despite findings connection child maltreatment criminal behavior paucity empirically based knowledge processes pathways link child maltreatment later involvement crime using community sample young adults ages metropolitan area present study examined role various facets impulsivity linking child maltreatment crime series factor analyses identified three types crime including property crime violent crime fraud structural equation modelings conducted examine associations among childhood maltreatment four facets impulsivity criminal behavior controlling sociodemographic information family income psychological symptoms present study found child emotional abuse indirectly related property crime fraud urgency lack premeditation mediates relationship child neglect property crime child physical abuse directly related three types crime personality traits urgency lack premeditation may play significant role maltreatment crime link preventive interventions targeting impulsivity traits urgency lack premeditation might promising impacts curbing criminal behavior among maltreatment victims elsevier inc rights reserved
background objective preoperative planning bone fractures using information scans increases probability obtaining satisfactory results since specialists provided additional information surgery reduction complex bone fractures requires solving puzzle order place fragment correct position computer assisted solutions may aid process identifying number fragments location calculating fracture zones even computing correct position fragment main goal paper development automatic method calculate contact zones fragments thus ease computation bone fracture reduction methods paper automatic method calculate contact zone two bone fragments presented previous step bone fragments segmented labelled images point cloud generated bone fragment calculated contact zones enable automatic reduction complex fractures end automatic method match bone fragments complex fractures also presented results proposed method successfully applied calculation contact zone different bones ankle area calculated fracture zones enabled reduction tested cases using presented matching algorithm performed tests show reduction fractures using proposed methods leaded small overlapping fragments conclusions presented method makes application puzzle solving strategies easier since obtain entire fracture zone contact area pair fragments therefore necessary find correspondences fracture zones fragments may aligned two two developed algorithms successfully applied different fracture cases ankle area small overlapping error obtained performed tests demonstrates absence visual overlapping figures elsevier ireland ltd rights reserved
objective study explored whether age moderated cognitive symptom functional changes week compensatory cognitive training cct intervention participants severe mental illnesses cct focused cognitive domains attention learning prospective memory executive functioning often impaired population method seventy seven unemployed individuals participants severe mood disorders participants schizophrenia schizoaffective disorder mean age years received cct weeks context supported employment program participants administered cognitive symptom severity functional measures baseline month follow ups well months symptom functional measures mixed effects models controlling diagnosis examined whether age impacted trajectories change following cct results analyses showed several significant time age interactions younger participants improved time category fluency beta financial capacity ucsd performance based skills assessment beta whereas older participants showed greater reduction positive symptom severity positive negative syndrome scale beta less functional decline independent living skills survey beta conclusions implications practice age moderated effects cct time measures cognition symptom severity functioning younger participants improved objective measures verbal processing speed financial capacity whereas older participants showed reduced positive symptom severity less decline self reported daily functioning findings suggest cct may differentially benefit persons severe mental illnesses depending age
paper presents creation network monitoring parameters route cargo vehicles decree law cargo vehicles must contain tachograph device collects records information practiced trip speed distance rpm rotations per minute among parameters data provided tachograph sent network collected interpreted atcan microcontroller sent monitoring station serial communication tracker mtc thus central monitoring company quickly follow route drivers characteristics travel practiced
background vast amount literature exists concerning pharmaceutical adherence osteoporosis however process learning live osteoporosis time remains largely unknown purpose study gain deeper understanding continued process women learn live osteoporosis objective explore characterizes women experiences living osteoporosis first year diagnosis patients prescribed anti osteoporotic treatment without experienced osteoporotic fracture methods forty two narrative qualitative interviews conducted fifteen recently diagnosed danish women longitudinal design chosen since allows investigation perspective time interviews conducted period march august data analyzed using phenomenological hermeneutic interpretation text medical records available researchers information exception score self reported results participants experiences could described two key themes developed analysis become influenced medical treatment consisted two sub themes taking medication discontinuing medication daily life osteoporosis characterized three sub themes interpretation symptoms interpretation scan results lifestyle reflections results highlighted learning live osteoporosis multifaceted process highly influenced medical treatment cases prolonged process take around one year conclusions results suggest need improved support individual women complex process learning live osteoporosis study adds new knowledge useful healthcare professionals taking health oriented stance supporting women self management illness investigations lived experiences time field osteoporosis research therefore needed
background calcitonin gene related peptide provokes migraine attacks patients migraine without aura whether aggregation migraine first degree relatives family load high number risk conferring single nucleotide polymorphisms contributes migraine susceptibility calcitonin gene related peptide infusion migraine patients unknown hypothesized genetic enrichment plays role triggering migraine therefore migraine without aura patients high family load would report migraine attacks calcitonin gene related peptide infusion patients low family load methods allocated previously genotyped migraine without aura patients receive intravenous infusion min calcitonin gene related peptide recorded migraine attacks including headache characteristics associated symptoms information familial aggregation obtained telephone interview first degree relatives using validated semi structured questionnaire results calcitonin gene related peptide infusion induced migraine like attack patients high family load compared low family load addition found migraine response calcitonin gene related peptide associated specific high number risk conferring single nucleotide polymorphisms migraine without aura conclusion found statistical association familial aggregation migraine hypersensitivity calcitonin gene related peptide infusion migraine without aura patients also demonstrated currently known single nucleotide polymorphisms conferring risk migraine without aura additive effect calcitonin gene related peptide induced migraine like attacks
background safety efficacy aerobic exercise heart failure patients atrial fibrillation well evaluated objectives study examined whether outcomes exercise training vary according status methods action heart failure controlled trial investigating outcomes exercise training randomized ambulatory patients ejection fraction conclusions patients chronic associated older age reduced exercise capacity baseline higher overall rate clinical events differential response exercise training clinical outcomes changes exercise capacity heart failure controlled trial investigating outcomes exercise training action american college cardiology foundation
purpose two randomized intra individual comparison studies performed healthy subjects evaluate skin moisturization barrier restoration potential new topical panthenol containing emollient ntp study effect skin microflora study methods study two skin areas one challenged sodium dodecyl sulfate sds solution one unchallenged treated ntp weeks transepidermal water loss tewl skin hydration intercellular lipid lamellae icll organization measured regular intervals study study quantitative bacterial cultures obtained skin area undergoing wash stress sds subsequent single application ntp results study mean auc tewl reduction baseline pronounced ntp compared control ntp use also associated statistically significant improvements stratum corneum hydration increase mean icll length baseline day study ntp use negative impact bacterial viability conclusions ntp use favorable lasting effects barrier function repair well skin hydration without negatively influencing bacterial viability
recent decades biological therapy enabled disease activity control improved quality life patients autoimmune diseases therapies involved immune response modifications change multiple immunological pathways induce incremental risk certain infectious diseases though recent advances risk assessment biological therapy lack data recommendati ons assessing risks populations high prevalence infectious diseases located tropical areas developing countries performed review infections biological therapy well strategies risk minimization areas high prevalence tropical diseases
xml pervasive technology representing accessing semi structured data xpath standard language navigational queries xml documents growing demand efficient processing order increase efficiency executing four navigational xml query primitives namely descendants ancestors children parent introduce new paradigm traditional approaches based efficient traversing nodes edges reconstruct requested subtrees replaced brand new one based basic set operations allow directly return desired subtree avoiding create passing nodes edges solution stems nested sets object hierarchies neastor formal model makes use set inclusion relations representing providing access hierarchical data define memory efficient data structures implement nestor develop algorithms perform descendants ancestors children parent query primitives study computational complexity conduct extensive experimental evaluation using several datasets digital archives ead collections inex wikipedia collection two widely used synthetic datasets xmark xgen show nestor based data structures query primitives consistently outperform state art solutions xpath processing execution time competitive terms memory occupation pre processing time elsevier ltd rights reserved
paracoccidioidomycosis pcm important systemic mycoses latin america describe severe case paracoccidioidomycosis year old boy rapid disease progression fungal strain isolated inoculated cell immunocompromised mice revealed highly virulent strain case report presented herein emphasizes importance considering pcm differential diagnosis patients infectious diseases endemic areas highlights novel isolate
quality function deployment qfd model optimal decision making model applied design special shaped stone machining center establishment design house quality machining center convert users needs requirements improvement machining center engineering measures shape design machining center manufacturing engineering time combine resource consumption various engineering measures implemented resources enterprises together constrains limited resource order make design machining center meet customers needs maximum extent enhance competitiveness machine tool market optimal decision model used select vital engineering measurement designing machining tool
purpose determine prevalence postkeratoplasty fungal infection corneal tissue donors recent medical history oral thrush respiratory urine wound sputum bronchial tracheal throat culture positive fungus identified recovery decontamination corneal tissue povidone iodine flush donors eyes recovery methods prospective analysis corneas donors documented medical history fungus positive fungal culture recovered january november standard aseptic swab donors corneas application povidone iodine solution performed culture results analyzed relationship donors medical history potential posttransplantation infections results eighty four eyes patients swabbed cultures study period seven eyes positive fungal growth treatment povidone iodine whereas positive fungal cultures treatment fifty four corneas study group used corneal transplantation cases fungal infection postkeratoplasty eyes transplanted study group conclusions small study overall prevalence fungal infections corneal transplantation using corneal donor tissue donors fungal positive medical history low corneal fungal contamination donors history fungal infection positive fungal culture significantly reduced povidone iodine flush
bone metabolism affected mechanical genetic environmental factors plays major role osteoporosis nevertheless influence environmental pollution occurrence osteoporosis still unclear controversial context heavy metals important pollutants capable affect bone mass aim study investigate whether heavy metals accumulation bone tissues could related altered bone metabolism architecture osteoporotic patients end analyzed bone head biopsies osteoporotic patients bone head biopsies osteoarthritic patients moreover enrolled patients underwent hip arthroplasty high energy hip fracture osteonecrosis femoral head control group bone head biopsies studied bioquant osteo software scanning electron microscopy energy dispersive ray microanalysis found prevalence lead cadmium chromium accumulation osteoporotic patients noteworthy high levels sclerostin detected immunohistochemistry correlate accumulation heavy metal found bone osteoporotic patients suggesting molecular link heavy metal accumulation bone metabolism impairment conclusion presence heavy metals bone shed new light comprehension pathogenesis osteoporosis since elements could play non redundant role development osteoporosis cellular molecular epigenetic level nevertheless vivo vitro studies need better elucidate molecular mechanism heavy metals participate osteoporosis wiley periodicals inc environ toxicol
purpose controversy exists gender affirmative treatment offered individuals gender dysphoria existing psychosis concerns exist regarding high risk misdiagnosis regret afterward due impulsive decision making deterioration psychotic symptoms case series aims extending sparse literature treatment population identifying challenges diagnosis treatment offering recommendations overcome case series authors present case descriptions two transgender men two transgender women age range years diagnosis schizophrenia related diagnosis undergone treatment minimum follow years gender diagnosis complicated fact feelings shared onset psychosis treatment hampered persistence mild psychotic symptoms despite antipsychotic treatment close communication psychosis treating clinicians proved useful address problems treatment paralleled stabilization psychotic symptoms adherence satisfaction therapy high conclusion case examples show treatment possible safe vulnerable population
new system model based state space representation received signal narrow band interference suppression direct sequence spread spectrum system given model recursively estimates interfering signal presence desired information white gaussian noise improve performance employ mmse criteria estimate transmitted symbols mmse estimate requires low computational complexity code aided techniques simulation results demonstrate technique provides better sinr improvement nonlinear predictor linear predictor kalman bucy predictor input sinr awgn power high interfering signal noise power results clearly show sinr improvement performance exceeds sinr improvement upper bound calculated prediction based techniques besides reducing effect interfering signal technique also reduces awgn noise model also provides better ber performance nonlinear predictor
mechanism early recurrence hepatocellular carcinoma hcc well understood examine whether early intrahepatic metastasis hcc determined reliable molecular characteristics primary hcc focused early stage tumors primary solitary hcc cases proteomic differences investigated two groups early recurrence within months late recurrence within months hcc cases using two dimensional fluorescence difference gel electrophoresis overall upregulated downregulated proteins identified total protein spots detected early recurrent hcc cluster analysis using proteins successfully divided hcc samples exactly two groups multifunctional protein transglutaminase tgm upregulated early recurrence group immunohistochemistry revealed frequent observation tgm positive hcc cells early group tendency tgm positive staining hcc cells adjacent fibrous stroma examine whether two major tgm associated pathways epithelial mesenchymal transition emt integrin signaling activated early recurrence group hcc downstream molecules tgm measured mrna level emt related genes highly positively correlated tgm mrna however cadherin cdh mrna protein downregulated correlation tgm expression phosphorylation fak akt downregulation pten associated quantity tgm therefore tgm might contribute early hcc recurrence signaling pathways related emt integrin signaling proteomics strictly classified hccs would useful characterizing pro metastatic hcc developing new therapeutic target treatment metastasis
gestational diabetes mellitus gdm pregnancy induced complication increased prevalence especially overweight women fatty acid composition tissues reflect dietary fat intake especially essential intake moreover shown profiles blood lipid fractions altered diabetic patients consequently women gdm may also distinctive profile objective review compare profiles different blood lipid fractions influence dietary fat intake women gdm normoglycemic pregnancies results show women gdm saturated less polyunsaturated pufa red blood cell rbc membranes normoglycemic pregnant women moreover studies reported women gdm greater energy intake total fat saturated along lower energy intake pufa compared normoglycemic pregnancies clinical trials showed omega pufa levels rbc membranes gdm women restored dietary intervention research required determine whether profiles altered prior diagnosis gdm prevented diet elsevier rights reserved
people interpret behavior making inferences agents intentionality mind personality past research studied inferences time real life people make inferences simultaneously present studies therefore examined whether major inferences intentionality desire belief personality elicited simultaneously response observed behavior might ordered hierarchy likelihood speed achieve generalizability studies included wide range stimulus behaviors presented verbally dynamic videos assessed inferences retrieval paradigm measuring likelihood speed accessing inferences immediately made online processing paradigm measuring speed forming inferences behavior observation five studies provide evidence hierarchy social inferences intentionality desire belief personality stable across verbal visual presentations parallels order found developmental primate research
nowadays tremendous growth internet things iot applications seen smart environments medical remote care applications crucial due general aging population recent advancements iot based healthcare technologies activity recognition used key part intelligent healthcare systems monitor elderly people live independently homes promote better care recently evidence theory derivates approaches began take place fields activity recognition smart systems however approaches generally inconsistent probability calculus due lower upper probability bounds considering combined evidences overcome challenges get precisely reconcilement evidence theory frequentist approach probability calculus work proposes new methodology combining beliefs addressing disadvantages exhibited evidence theory derivatives methodology merges non normalized conjunctive majority rules proposed rule evaluated numerical simulation case studies involving activity recognition smart home environment results show strategy produces intuitive results favor committed hypothesis
robust precise control piezoelectric actuators quite challenging due existence strong hysteresis nonlinearities paper control strategy proposed based uncertainty disturbance estimator ude improve performance positioning control piezoelectric actuators compared existing hysteresis inversion based robust control strategies ude based controller achieve excellent positioning precision without knowledge bound shape hysteresis simulation results presented illustrate effectiveness ude based controller system dynamics piezoelectric actuator characterized second order linear system preceded symmetric asymmetric generalized prandtl ishlinskii gpi input hysteresis model extraordinary capability ude based controller demonstrated smart material based actuators magnetostrictive shape memory alloys sma hysteresis characterized saturated gpi model
key clinical message case suggests initiation hcv therapy immediately liver transplantation well tolerated oral regimens may achieve virologic cure hcv positive recipients thus preventing post transplant hcv recurrence associated disease progression strategy may broaden utilization hcv positive donor livers potentially including hcv negative transplant recipients
objectives induce disease remission early arthritis patients adhere disease modifying antirheumatic drugs dmard first months diagnosis remains unknown patients non adherent aimed identify patients risk non adherence first months treatment methods adult dmard naive early arthritis patients starting synthetic dmards filled items potential adherence predictors baseline adherence measured continuously non adherence defined opening electronically monitored pill bottle items reduced clustered using principal component analysis discriminating items identified latent trait models used multivariable logistic regression model find non adherence predictors results patients agreed participate adherence high declined time principal component analysis led dimensions subsequent latent trait models analyses led dimensions two dimensions associated adherence one dimension associated nonadherence conclusions information seeking behavior positive expectations course disease associated adherence patients become passive pain risk non adherence practice implications rheumatologists cues identify non adherence may intervene nonadherence implementing shared decision making techniques elsevier ireland ltd rights reserved
sustained interest environmental regulators livestock associations expand use anaerobic digester technology mitigate greenhouse gas emissions however generally profitable practice codigesting farm organic waste could increase nitrogen phosphorus content farm exacerbate nutrient application concerns near large animal operations examine economic feasibility broad set dairy waste management systems composed two technology groups mitigate air water pollution system includes either animal waste input combination animal farm organic waste codigestion input either compressed natural gas cng combined heat power chp output filtration system includes fiber separation nutrient separation water recovery conclude setups without codigestion economically feasible limited conditions scenarios use codigestion potential contribute nutrient application without nutrient separation technology trends cng chp match closely net present value npv greatest cng scenarios estimated npv cng environmental credits million million dairies wet cow equivalents respectively firm sizes addition codigestion contributes million million respectively estimated npv nutrient separation water recovery lead decreases scenario npv codigestion right policies dairy owners may willing adopt nutrient separation published elsevier ltd
brief robust sparse recursive adaptive filtering algorithm called convex regularized recursive maximum correntropy rmc derived adding general convex regularization penalty term maximum correntropy criterion mcc approximate expression automatically selecting regularization parameter also introduced simulation results show rmc significantly outperform original recursive maximum correntropy rmc algorithm especially underlying system sparse compared convex regularized recursive least squares rls algorithm new algorithm also shows strong robustness impulsive noise rmc also performs much better lms type sparse adaptive filtering algorithms based mcc elsevier rights reserved
trees fundamental structure algorithmics paper study transformation arbitrary binary tree vertices completely balanced tree via rotations widely studied elementary tree operation combining concepts rotation distance data structures give basic algorithm performs transformation similar time similar space making log rotations improving known previous results algorithm improved exploiting particular properties finally show tighter upper bounds obtain close lower bound rotation distance zig zag tree completely balanced tree also find exact rotation distance particular almost balanced tree completely balanced tree thus show distance quite large despite similarity two trees
athletes higher risk general population eating disorders risk heightened athletes thin build sports including track collegiate athletes particularly vulnerable disordered eating transition home college environment adds stress performance pressures high demands sport environment male female athletes develop eating disorders share common characteristics yet experiences quite different part consequence sex eating disorders develop recognized acknowledged treated within culture sports case report describes experiences two track athletes one male one female recruited division collegiate track program elite athletes freshmen year experiencing urban college environment experiencing eating disorder characterized restrictive eating significant weight loss injury compromised performance sport received treatment multidisciplinary team professionals athletes achieved weight restoration recovery disorder success sport spite similarities striking differences apparent clinical presentation predisposing features onset symptoms entry points treatment interventions received clinical courses treatment depict sex differences eating disorders present athletes addressed sport environment findings endorse need research inform prevention strategies risk assessment intervention approaches nutrition sports medicine professionals collegiate athletic departments
focus study determine conformational structural vibrational properties methionyl serine dipeptide methionyl serine met ser biological active molecule investigate energetically preferred conformations molecular mechanics methods utilized determine optimal conformations different dihedral angle values backbone side chains found extended backbone shape conformational range stable lmethionyl serine dipeptide conformation kcal mol energy density functional theory dft used determine optimized geometry vibrational wavenumbers modes title dipeptide values basis sets potential energy distribution data used carry assignment bands addition vibrational spectra stable conformer dimer form determined obtained results compared experimental raman spectra solid phase determine presence intramolecular charge transfer molecular dipole moment polarizability hyperpolarizability natural bond orbital nbo homo lumo calculations linear polarizability alpha first order hyperpolarizability fio value analyses investigated molecule carried using dft blyp basis set study aims determine relatively stable conformation antioxidant dipeptide investigate molecular geometry molecular vibrations hydrogen bonding interactions monomeric dimeric forms methiony serine dipeptide elsevier rights reserved
objective propose phylogenetic significance moro reflex remains unexplained since publication hands free end gesture method among videos healthy term newborns filmed research project antenatal education parenthood describe sequence clearly showed successive movements moro reflex report occurrence reflex videos recorded time birth defined moment lies birth thorax pelvis infant results selected sequence showed following succession newborn actions quick extension adduction arms orientation body head eyes towards human person full extension abduction arms spreading fingers crying distressed face moro reflexes time birth found significant association occurrence moro reflex placement newborn birth supine position mother abdomen discussion quick extension adduction arms started sequence may considered startle reflex controlled neural fear system arm extension adduction followed moro reflex characteristics moro reflexes ritualization amplitude duration stereotype gestures evolutionary process turns physiological behavior grasping case non verbal communicative behavior whose meaning request picked arms gestures associated moro reflex crying orientation body head eyes towards human person gestures intention communicate support hypothesis neural mechanism moro reaction probably involves fear separation distress systems conclusion paper proposes first time phylogenetic significance moro reflex ritualized behavior nonverbal communication professionals avoid stimulating newborns fear system unnecessarily triggering moro reflexes antenatal education teach parents respond moro reflexes newborn infant picking arms mother talk elsevier inc rights reserved
objectives referencing self known enhance accurate memory less known strategy affects false memory particularly highly self relevant information older adults prone false memories tested whether self referencing increased false memories age method studies older younger adults rated adjectives self descriptiveness later completed surprise recognition test comprised words rated previously self descriptiveness novel lure words lure words subsequently rated self descriptiveness order assess impact self relevance false memory study introduced commonness judgments control condition participants completed recognition test adjectives rated commonness addition adjectives self descriptiveness condition results across studies findings indicate increased response bias self referencing increased hit rates older younger adults also increased false alarms information became self descriptive particularly older adults discussion although present study supports previous literature showing boost memory self referenced information increase false alarms especially older adults highlights potential memory errors particularly information strongly related self
temporary organizations projects known differ various respects permanent ones argued gender neutral inspired gender research permanent organizations show congruency gender project roles evokes similar mechanisms permanent temporary systems using example cooperative behavior operationalized project citizenship behavior pcb examine temporary organizations reward behaviour cross sectional study conducted project managers workers participating results seven structural equation models reveal though enactment pcb vary gender relationship pcb outcomes men women clearly rewarded differently depending gender congruency project roles elsevier ltd rights reserved
glazing transmittance variation clearness index higher influence incident angle soar energy application work presents variation vacuum glazing transmittance clearness index clearness index transmittance calculated measured one year solar radiation glazing transmittance data dublin ireland clearness index offer single value transmittance whereas clearness index glazing transmittance varies clearness index different azimuthal orientation clearness index associated vertical plane glazing transmittance proposed dublin south facing vertical plane vacuum glazing transmittance clearness index yearly usable single transmitted solar energy solar heat gain coefficient vertical plane south facing vacuum glazing respectively elsevier ltd rights reserved
introduction objective increasing mental load inadequate stress management significantly affect efficiency success safety educational working process adolescents objective study determine extent adolescents compensate school mental load physical activity weekend days thus contribute objective measurement mental load natural working conditions methods cross sectional study conducted september april set different methods employed self administered questionnaire ipaq long questionnaire objective measurements pedometers accelerometers actitrainers distributed students high schools participants mental load assessed based difference intensity physical inactivity heart rate range results participants highest mental load school lessons compensate load weekend days conclusions adolescents need encouraged aware subjective mental load intentionally compensate load weekend days necessary support process adopting habits sufficient physical literacy students well teachers changes school program
hiv stigma inhibit uptake hiv testing antiretroviral therapy well negatively affect mental health efforts reduce discrimination people living hiv lwh contributed greater acceptance infection female sex workers fsw lwh may experience overlapping stigma due work hiv status although poorly understood examined hiv sex work stigma experienced fsw lwh zimbabwe using sapph ire cluster randomised trial baseline survey analysed data fsw self reporting hiv women recruited sites using respondent driven sampling asked five questions assess internalised experienced stigma related working sex worker questions asked reference hiv among fsw reported form sex work stigma associated sociodemographic sex work characteristics rates sex work stigma higher hiv related stigma example reported talked badly lwh compared involvement sex work reported sex work stigma also reported experiencing hiv stigma compared report sex work stigma suggesting layering effect fsw zimbabwe experience stigma role immoral women appears prevalent hiv stigma hiv stigma attenuates forms social stigma associated disease may persist continue pose barriers effective care
work related stress significant socio economic problem widely discussed developed countries today health care professionals among professionals experience high level stress long workdays high case loads working time pressure high expectations others low tolerance error according american psychological association yoga one activities helping manage work related stress classic eastern approach seems useful dealing modern western problem many papers role yoga stress management studies exploring effect yoga stress among health care professionals would like present results single arm pilot study military hospital olomouc could serve basis larger randomized control trial among health care professionals czech republic
constructive nature memory generally adaptive allowing efficiently store process learn life events simulate future scenarios prepare may come however cost flexibly constructive memory system occasional conjunction error whereby components event authentic combination components false using novel recombination paradigm demonstrated details one autobiographical memory may incorrectly incorporated another forming conjunction errors elude typical reality monitoring checks factors contribute creation conjunction errors examined across two experiments conjunction errors likely occur corresponding details partially rather fully recombined likely due increased plausibility ease simulation partially recombined scenarios brief periods imagination increased conjunction error rates line imagination inflation effect subjective ratings suggest inflation due similarity phenomenological experience conjunction authentic memories consistent source monitoring perspective moreover objective scoring memory content indicates increased perceptual detail may particularly important formation conjunction errors
background aim psoriasis accepted systemic disease known associated various disorders including metabolic syndrome high serum uric acid levels also associated components metabolic syndrome study aimed determine serum uric acid levels patients psoriasis association uric acid levels disease activity taking presence metabolic syndrome criteria account since one important factors affect serum uric acid levels materials methods cross sectional study evaluated psoriasis patients healthy individuals matched patients according presence metabolic syndrome evaluated demographic features levels serum uric acid psoriasis area severity index pasi scores presence psoriatic arthritis nail involvement metabolic syndrome criteria patients results serum uric acid levels psoriasis patients significantly higher controls positive correlation pasi scores serum uric acid levels patients conclusion hyperuricemia close relationship psoriasis pasi scores suggest monitoring patients psoriasis serum uric acid levels treatment follow
intraoperative transcranial motor evoked potential monitoring causes contraction masseter muscles may cause injuries oral cavity damage orotracheal tube developed mouthpiece made vinyl silicone impression material prevent injuries purpose study examine efficacy safety twenty two patients undergoing spinal surgery transcranial motor evoked potential monitoring fitted bespoke vinyl silicone mouthpieces dentists surgery induction general anesthesia orotracheal intubation mouthpiece attached upper lower dental arches lateral cervical ray taken end surgery examine condition orotracheal tube incidence endotracheal tube deformation compared historic control group patients conventional gauze bite block previously used induction mouthpiece oral cavity examined dentist day surgery days postoperatively intraoral injuries recorded endotracheal tube deformation found patients fitted new mouthpiece incidence tube deformation none patients significantly lower fitted gauze bite block patients application mouthpiece resulted tongue tooth injuries novel mouthpiece reduced incidence damage endotracheal tube caused intraoperative transcranial motor evoked potential monitoring
public opinion research repeatedly shown religious people generally report prejudice homosexuality however previous research exploring general mechanisms underpin relationship mostly relied christian samples north america studies outside north america number limited forms religiosity address indicators studied far religious quest orientation found one negatively related anti gay sentiments leaves open question whether mechanisms different forms religiosity also found outside north america background research note assesses religious quest orientation self rated religiosity religious behavior authoritarianism related prejudice homosexuality among christian muslim youth aged flanders study first investigates relationship religious quest orientation anti gay sentiments among muslims christians muslims found even taking account wide range social background religious characteristics religious quest orientation related less prejudice toward homosexuality
introduction alzheimer disease neuroimaging initiative adni continued development standardization methodologies biomarkers provided increased depth breadth data available qualified researchers review summarizes publications using adni data methods used standard searches find publications using adni data results structural functional changes including subtle changes hippocampal shape texture atrophy areas outside hippocampus disruption functional networks detectable presymptomatic subjects hippocampal atrophy subjects abnormal beta amyloid deposition beta biomarkers become abnormal order predicted amyloid cascade hypothesis cognitive decline closely linked tau beta deposition cerebrovascular risk factors may interact beta increase white matter abnormalities may accelerate alzheimer disease progression conjunction tau abnormalities different patterns atrophy associated impairment memory executive function may underlie psychiatric symptoms structural functional metabolic network connectivities disrupted progresses models prion like spreading beta pathology along tracts predict known patterns cortical beta deposition declines glucose metabolism new risk protective gene loci identified using biologically informed approaches cognitively normal mild cognitive impairment mci subjects heterogeneous include groups typified classic pathology also normal biomarkers accelerated decline suspected non alzheimer pathology selection subjects risk imminent decline basis one pathologies improves power clinical trials sensitivity cognitive outcome measures early changes cognition improved surrogate outcome measures using longitudinal structural magnetic resonance imaging may reduce clinical trial cost duration advances machine learning techniques neural networks improved diagnostic prognostic accuracy especially challenges involving mci subjects network connectivity measures genetic variants show promise multimodal classification classifiers using single modalities rivaling multimodal classifiers discussion taken together studies fundamentally deepen understanding progression underlying genetic basis turn informs improves clinical trial design published elsevier inc behalf alzheimer association
reports association polymorphisms oral cancer limited also specific site gender hence examined effect polymorphisms ivs ins ivs buccal mucosa cancer bmc tongue cancer risk survival patients relation risk clinical factors gender wise excepting estimating hazards ratio using fisher exact test kaplan meier analysis cox proportional hazards models exonic polymorphism increased bmc risk males fold ivs ins protective bmc genders whereas ivs protected males genotype combinations haplotypes altered risk cancers males females different males aged years females aged years survived better bmc patients ivs ins polymorphism differentially impacted survival female patients exposed tobacco patients lymphovascular spread lvs metastasis exhibited higher patients perineural invasion pni showed lower impact intronic variants along clinical parameters survival estimates varied bmc bioinformatics analysis revealed presence ctcf binding site within gene conclusion polymorphisms altered risk survival bmc gender specific manner varied mode tobacco alcohol use current study therefore underscores strong need research stratified tumor site gender wiley periodicals inc
qualitative analysis focus groups describes neighborhood design encourages active aging nine focus groups conducted residents aged living portland usa content analysis revealed local shopping services traffic pedestrian infrastructure neighborhood attractiveness public transportation influence activity among older adults information useful making policy recommendations relating land use planning transportation assist senior friendly developments neighborhood improvements design effective senior health interventions emphasis neighborhood design influences elsevier ltd rights reserved
background hepatocellular carcinoma hcc one fastest rising causes cancer related mortality united states despite improved hcc screening surveillance guidelines significant race ethnicity specific disparities hepatocellular carcinoma remain disproportionately affecting risk racial minorities current review aims provide updated analysis race ethnicity specific disparities hcc epidemiology focus predisposing risk factors conclusion among different race ethnicities hispanics experienced greatest burden hcc particularly residing south texas important understand underlying etiologies disparities complex multi factorial risk factors developing chronic liver disease include non alcoholic fatty liver disease non alcoholic steatohepatitis alcohol use addition population genetics acculturation ethnic minorities access healthcare may contributing observed disparities hcc increasing awareness improved modalities screening surveillance hcc important guiding future research targeted preventive therapeutic interventions
current logistics transportation systems include heterogeneous fleets consisting common internal combustion engine vehicles well types vehicles using green technologies plug hybrid electric vehicles electric vehicles evs however incorporation evs activities also raise additional challenges strategic planning operational perspectives instance smart cities required provide recharge stations electric based vehicles meaning investment decisions need made number location capacity stations similarly limited driving range capabilities evs restricted amount electricity stored batteries impose non trivial additional constraints designing efficient distribution routes accordingly paper identifies reviews several open research challenges related introduction evs activities including environmental related issues strategic planning operational issues associated standard evs hydrogen based evs paper also analyzes introduction evs systems generates new variants well known vehicle routing problem one studied optimization problems field proposes use metaheuristics simheuristics efficient way deal complex optimization problems
background paucity data describe clinical course hereditary angioedema hae children objective purpose study examine clinical features children hae methods electronic medical records past years cincinnati children hospital medical center outpatient allergy community practice searched icd code deficiencies circulating enzyme exclusion criteria included laboratory data supportive type hae diagnosis age diagnosis greater years chart review performed missing data collected telephone interviews patient families descriptive statistics performed using sas version results twenty one children identified median age years interquartile range iqr male hae family history caucasian median age symptom onset diagnosis iqr years iqr years respectively five children diagnosed asymptomatic three children without family history year delay diagnosis common angioedema attack sites abdominal peripheral laryngeal occurred least respectively children onset symptoms children received demand therapy acute attack whereas children administered either short term long term prophylaxis therapy conclusions pediatric hae population symptom onset diagnosis occurred median age years delay diagnosis without family history abdominal attacks common peripheral attacks population american academy allergy asthma immunology
objectives determine role microrna mir interleukin beta beta induced extracellular matrix ecm degradation nucleus pulposus results mir regulated degenerative tissues beta stimulated cells compared levels normal controls normal tissue specimens patients idiopathic scoliosis bioinformatics luciferase activity analyses showed mothers decapentaplegic homolog smad key mediator transforming growth factor beta signaling pathway directly targeted mir functional analysis demonstrated mir overexpression aggravated beta induced ecm degradation cells mir inhibition opposite effects prevention beta induced ecm degeneration mir inhibitor attenuated small interfering rna mediated knockdown smad addition activation map kinase nuclear factor kappa regulated mir expression regulated smad expression beta stimulated cells conclusions mir contributes ecm degradation intervertebral disc degeneration idd via targeting smad thus providing novel therapeutic target idd treatment
chronic obstructive pulmonary disease complex disease pulmonary systemic manifestations increased risk serious comorbidity mortality although chronic obstructive pulmonary disease often progressive pharmacological non pharmacological interventions significantly ameliorate severity impact symptoms reduce frequency exacerbations stopping smoking pulmonary rehabilitation key interventions mild symptoms managed short acting inhaled bronchodilators one two long acting bronchodilators added symptoms persist role inhaled corticosteroids questioned may benefit patients optimal therapy includes reviewing patients inhaler use ensuring self management plan enables promptly start treatment infection exacerbations future treatment likely combine multidimensional management approach tailored treatment clinical phenotyping
objective equol active metabolite possessing estrogen like activity produced action intestinal flora soy isoflavones increasing evidence regarding efficacy relief menopausal symptoms suppression decreased bone mineral density lipid profile improvement equol producing capacity however seem benefit thus examined relationship equol producer status parameters associated lifestyle related diseases women methods cross sectional study conducted among women average age undergone health screening tokyo midtown medical center given consent participate study relationship equol producer status metabolic parameters assessed results study women equol producers equol producers significantly lower triglycerides higher high density lipoprotein cholesterol levels compared nonproducers equol producing women showed significantly lower body fat level visceral fat area triglyceride levels pulse wave velocity uric acid levels high sensitivity reactive protein levels addition women showed significantly higher levels high density lipoprotein cholesterol multivariate logistic regression women equol production significantly associated lower arterial stiffness uric acid levels high ratio eicosapentaenoic acid arachidonic acid whereas significantly associated lower urinary telopeptides conclusions equol producer status associated favorable metabolic parameters women early phase postmenopause transitional periods noted declining intrinsic estrogen levels
young children share fairly expect others yet little known underlying cognitive mechanisms support fairness investigated whether children numerical competencies linked sharing behavior preschoolers aged participated third party resource allocation tasks split set resources puppets children numerical competence assessed using give task sarnecka carey wynn numerical competence specifically knowledge cardinal principle explained age related changes fair sharing although many subset knowers without knowledge cardinal principle still able share fairly invoked turn taking strategies remember number resources shared results suggest numerical cognition serves important mechanism fair sharing behavior children employ different sharing strategies division turn taking depending numerical competence
background mindfulness based stress reduction mbsr initially used clinical settings also proved effective tool managing work related stress occupational groups inherently exposed certain psychosocial risks aims examine potential work related stress management using mbsr middle level managers considered particularly affected negative effects stress related organizational restructuring methods middle level managers participated randomized controlled study implemented experimental versus control group baseline post treatment study design yielding group comparison participants randomly assigned week intervention group wait list control group results results showed relative control group mbsr intervention significant effects several outcomes subjects including decreases perceived work related stress diff negative affect diff intensity somatic complaints diff sickness absence diff increase self esteem diff positive affect diff effects found frequency somatic complaints conclusions results suggest mbsr effective method managing work related stress bolstering psychological resilience workplace particularly face psychosocial risks global economic nature
design solution bulk driven tunable transconductor capable working extremely low supply consumption rail rail input common mode range presented work proposed transconductor topology consists six bulk driven cmos inverters uses simple biasing circuit transconductance tuning design robustness verified power supplies offering advantages current controlled input transconductance power supply proposed transconductor transconductance tuning range input referred intercept point mhz bandwidth current consumption design robustness tunable transconductor verified means computer simulation using triple well cmos process
background haematopoietic stem cell transplantation curative treatment option many haematological disorders infection following haematopoietic stem cell transplantation one major causes mortality aims investigate outcomes early cessation empirical antibiotic treatment per protocol febrile neutropenia patients undergone haematopoietic stem cell transplantation clinic study design descriptive study methods present study retrospectively evaluated febrile neutropenia attacks haematopoietic stem cell transplantation recipients period june january haematopoietic stem cell transplantation clinic results total febrile neutropenia attacks evaluated patients febrile neutropenia attacks microbiologic cultures revealed positive results culture positive febrile neutropenia episodes single bacterium isolated cases multiple strains isolated patients empirical antibiotic therapy discontinued hours patients clinically stable without evident focus infection negative culture results recurrent episodes observed cessation antibiotherapy patient died result recurrent infection day day post transplantation mortality rates patients febrile neutropenia episodes respectively infection related day day mortality rates respectively conclusion main message study early cessation empirical antibiotherapy seems feasible eligible patients without increasing febrile neutropenia mortality rates
prior research suggested dental students experience high rates stress anxiety mood concerns linked poor academic performance health concerns substance abuse aim study evaluate impact embedded counseling office university iowa college dentistry dental clinics first three academic semesters data gathered students attending appointments two inventories used monitor students counseling progress gather psychological outcomes data counseling center assessment psychological symptoms ccaps outcome rating scale ors three semesters students attended counseling appointments average appointments per student presenting psychological concerns included academic concerns time management test anxiety study skills low self esteem self care interpersonal conflicts anxiety depression stress management sexual concerns substance abuse eating body image concerns work life balance financial issues ccaps data showed initial clinical assessment students experienced moderate levels depression generalized anxiety social anxiety academic distress overall psychological distress showed clinically significant symptoms least one ccaps subscale ors data showed students entered counseling experiencing high levels psychological distress positive relationship found number counseling appointments increased overall functioning results suggest embedded counseling office help dental schools meet needs students
rationale interstitial lung disease ild heterogeneous group acute chronic inflammatory fibrotic lung diseases existing ild registries variable findings little known clinical profile ilds india objectives characterize new onset ilds india creating prospective ild using multidisciplinary discussion mdd validate diagnoses methods adult patients indian origin living india new onset lld centers indian cities march june without malignancy infection included connective tissue disease ctd serologies spirometry high resolution computed tomography chest ild pattern definedby high resolution computed tomography images three groups independently made diagnoses review clinical data including prompted case report forms local site investigators ild experts national data coordinating center ndcc jaipur india mdd experienced ild experts center ild cild seattle mdd cohen used assess reliability interobserver agreement measurements main results total patients recruited final diagnosis hypersensitivity pneumonitis exposure air coolers ctd ild idiopathic pulmonary fibrosis cohen site investigator cild site investigator ndcc ndcc cild conclusions hypersensitivity pneumonitis common new onset ild india followed ctd ild idiopathic pulmonary fibrosis diagnoses varied site investigators cild experts emphasizing value mdd ild diagnosis prompted case report forms including environmental exposures prospective registries likely provide insight etiology management ild worldwide
requirements analysis software engineering stage closest users world also involves tasks knowledge intensive thus use bayesian networks bns model knowledge would valuable aid probabilistic models could manage imprecision ambiguities usually present requirements engineering work conduct literature review focusing bns applied subareas order identify gaps remain uncovered methods might engineers employ incorporate intelligent technique requirements processes scarcity identified studies suggests areas properly investigated literature evidence available adopting bns sufficiently mature yet methods applied easily translatable topics nonetheless enough studies supporting applicability synergistic cooperation bns work provides background understanding current state research encompassing bns functional non functional ilities requirements artifacts enhanced use bns models obtained interacting experts learning databases common criticism point view experts models lack validation whereas requirements engineers point lack clear application method bns lack tools incorporating built help functions
narratives important component culture play central role transmitting social values little known however brain listener reader processes narratives receiver response narration influenced narrator framing appeal values narratives appeal protected values including core personal national religious values may particularly effective influencing receivers protected values resist compromise tied identity affective value moral decision making aspects social cognition investigated neural mechanisms underlying reactions protected values narratives fmri scanning presented american chinese iranian participants real life stories distilled corpus million weblogs reading stories engaged posterior medial medial prefrontal temporo parietal cortices participants believed protagonist appealing protected value signal regions increased compared protected value perceived possibly reflecting intensive iterative search required process material effect strength also varied across groups potentially reflecting cultural differences degree concern protected values
direct torque control dtc employed give fast torque response important traction electric vehicle applications high dynamic performance induction motor drives fast torque response achieved optimizing selection inverter voltage vectors conventional dtc paper introduces method selecting voltage vectors dtc controlled drives achieve fast torque response constant switching frequency also application fuzzy pid fpid control technique improves system speed torque responses simulation results show torque speed responses faster proposed controller conventional dtc
oversuppression bone turnover explained association bisphosphonate use atypical subtrochanteric femur fractures aff could reversed anabolic treatment teriparatide conducted prospective open label study patients previously treated bisphosphonates sustained aff examining response month treatment teriparatide bone mineral density bmd trabecular bone score tbs bone turnover markers btm fracture healing well quantitative histomorphometry studied patients baseline bmd btm tbs varied widely initial bone biopsies patients showed tetracycline labels mineralizing surface bone surface published normal values lumbar spine bmd increased significantly month versus baseline whereas total hip bmd tbs change significantly changes btm occurred reported previously patients without aff treated teriparatide prior bisphosphonate treatment month fractures healed patients showed partial healing unchanged showed nonunion patient two fractures fracture occurred teriparatide treatment reported healed fracture occurred treatment showed partial healing bisphosphonate treated patients sustain aff show heterogeneity bone turnover treatment teriparatide resulted increases btm lumbar spine bmd reported patients without aff significant effect teriparatide hip bmd mineralizing surface bone surface tbs consistent effect fracture healing context patient experienced aff receiving bisphosphonate treatment therapy teriparatide months would expected increase bmd btm probably reduce risk fractures resulting osteoporosis relied aid healing aff american society bone mineral research
observational studies suggest closure patent foramen ovale indications may reduce even eliminate migraine attacks particularly migraine aura first randomized clinical trial patent foramen ovale pfo closure prevention migraine mist trial showed negative results results two completed studies area recently published last year prima premium also negative primary endpoints premium trial show reduction headache days migraine aura subgroup final results subset analysis published may yet undetermined subgroup patients migraine would benefit closure slow recruitment barrier study several potentially life threatening procedure related adverse events occurred clinical trials time recommend offering pfo closure preventive treatment migraine based available observational data patients pfo closure indicated reasons may see improvement migraines
preference learning branch machine learning charge inducing preference models data paper focus task known label ranking problem whose goal predict ranking among different labels class variable take contribution twofold taking basis tree based algorithm lrt described design weaker tree based models learnt efficiently show bagging weak learners improves lrt algorithm also state art one iblr furthermore bagging algorithm takes weak lrt based models base classifiers competitive time respect lrt iblr methods check goodness proposal conduct broad experimental study standard benchmark used label ranking problem literature elsevier rights reserved
study contains examination missing data structures occurring many fields especially livestock also examines processes obtain solution missing data purpose linolenic acid measurements obtained four different anatomic regions two animal species taken dependent variables dependent variable observations deleted ratio creating missing structures missing completely random mcar missing random mar subsequently data sets completed using multiple imputation method generalized estimating equation gee mixed model methods used missing data structures purpose evaluating data completed study obtained almost results obtained gee mixed model missing data structures time found difference methods completed data using method result stated valid results obtained missing data structures used gee mixed model analysis results also compared concluded multiple imputation ratio missing necessary gee mixed model
paper presents modulator active voltage balancing control three phase four level flc converter based electric motor drive applications supplied directly grid describes modulation algorithm drive phase shifted pwm modulation balancing voltage flying capacitor using controllers closed loop proposed control verified experiments carried scale drive prototype rated power kva
osteoarthritis affects large number population incidence showing growing trend increasing life span prevalent joint condition worldwide currently functional cure review seeks briefly overview management knee concerning standardized pharmaceutical clinical approaches well new biotechnological horizons treatment potential biomaterials state art advanced therapeutic approaches cell gene therapy focused primarily cartilage regeneration main subjects review biotechnol bioeng wiley periodicals inc
optimal estimation signal amplitude background level photocenter location crucial combined extraction astrometric photometric information focal plane images particular one dimensional measurements performed gaia intermediate faint magnitude stars goal define convenient maximum likelihood framework suited efficient iterative implementation assessment noise level bias correlation among variables analytical model investigated numerically verified simulation range magnitude background values estimates unbiased well understood correlation amplitude background much lower correlation either location alleviated case signal symmetry two versions algorithm implemented tested respectively independent combined parameter estimation effective provide consistent results latter efficient takes account flux background estimate correlation
background symptom clusters previously explored among individuals atrial fibrillation type objective purpose study determine number symptom clusters present among adults chronic atrial fibrillation explore sociodemographic clinical factors potentially associated cluster membership methods cross sectional secondary data analysis australian community dwelling adults chronic recurrent paroxysmal persistent permanent atrial fibrillation used self reported symptoms agglomerative hierarchical cluster analysis determine number content symptom clusters present results slightly male female participants mean age years three symptom clusters evident including vagal cluster nausea diaphoresis tired cluster fatigue lethargy weakness syncope dizziness dyspnea breathlessness heart cluster chest pain discomfort palpitations fluttering compared patient characteristics among symptoms cluster symptoms cluster none symptoms cluster statistically significant differences age gender use antiarrhythmic medications heart cluster women likely heart symptom cluster men individuals symptoms heart cluster younger years none symptoms heart cluster likely antiarrhythmic medications conclusion three unique atrial fibrillation symptom clusters identified study population
scientific software engineering distinct discipline computational chemistry project support research informatics scientific software engineer deep understanding science drug discovery also desire skills time apply good software engineering practices good team scientific software engineers create software foundation maintainable validated robust done correctly foundation enable organization investigate new novel computational ideas high level efficiency
micrornas mirnas type interfering rnas small similar nucleotides long remain evolutionary conserved reported large number plants including organisms like viruses insects higher vertebrates biological metabolic activities pivotal role gene silencing correlated number diseases therefore mirna prediction important challenging field spite significant medicinal plant specific work done yet micrornas mirnas potential targets cannabis sativa vitro prediction mirnas slow laborious process hard isolate current study well developed faster powerful silico approach est based homology search followed identify potential mirna sativa expressed sequence tag est database cannabis sativa blasted previously identified plant mirnas following series filtration criteria total potential mirnas identified furthermore potential mrna targets tagged sativa genome based complementarity mirnas targeted mrna sequences predicted target genes encode mainly transcriptional regulators including myb transcription factor gras family transcription factor scarecrow protein transcriptional regulator family protein dna binding protein targets specific functions developmental process sativa associated diverse metabolic processes stress management well metabolic functions include leucine rich protein kinase family protein retro element pol polyprotein pectin acetyl esterase set domain protein hxxxd type acyl transferase family protein ankyrin repeat family protein hypersensitivity related protein overall findings study pave way researches sativa mirnas functions elsevier rights reserved
purpose paper investigate flexible structure parabolic shell using photo strictive actuators analysis made know dynamic behavior light induced control forces coupled parabolic shell effects actuator location well membrane bending components control action analyzed considering approximate spherical model parabolic membrane shell accuracy mathematically approximated validated comparing light induced control forces using approximate equivalent spherical shell model parabolic shell kapton smart material photostrictive actuators used formulate governing equation transverse direction kirchhoff love assumptions used obtain governing equation shell actuator mechanical membrane forces bending moments parabolic thin shell actuator used analyze dynamic effect results show membrane control action much significant bending control action photostrictive actuators oriented along circumferential direction actuator give better control effect actuators placed along longitudinal direction actuator slight difference observed spherical parabolic shell surface focal length diameter ratio unity space applications often shape parabolical shells shell revolution due required focusing aiming reflecting performance present approach focused photostrictive actuators effectively control vibration parabolical membrane shell also actuator location plays important role defming control force
increase non linear loads electrical network deteriorates voltage waveform quality one used methods correct quality lack use shunt series mixed topologies active power filters mixed filters compensate loads generate voltage harmonics current harmonics economic investment high commercial shunt filters widespread due design modularity cost although non linear load tracking capability limited aim work improve shunt active filter reference tracking designing variable reactance filter output validity proposed design analyzed matlab simulink platform
decades research demonstrated exposure violence television cause increases aggression recent emergence violent video games raised new questions regarding effects violent media general aggression model gam predicts exposure violent media increases aggressive behavior one three primary pathways arousal cognitions affect past psychophysiological research supported gam limited examining arousal related variables recent advances social neuroscience opened door investigations exposure violent media cognitive affective components neurocognitive underpinnings neuroscience tools potential provide answers new questions posed recent advances media technology
quest developing realistic facial animation ever growing emergence sophisticated algorithms new graphical user interfaces laser scans advanced tools imparted impetus towards rapid advancement complex virtual human facialmodel face face communication natural way human interaction facial animation systems became attractive information technology era sundry applications production computer animated movies using synthetic actors still challenging issues proposed facial expression carries signature happiness sadness angry cheerful etc mood particular person midst large group immediately identified via subtle changes facial expressions facial expressions complex well important nonverbal communication channel tricky synthesize realistically using computer graphics computer synthesis practical facial expressions must deal geometric representation human face control facial animation developed new approach integrating blend shape interpolation bsi facial action coding system facs create realistic expressive computer facial animation design bsi used generate natural face facs employed reflect exact facial muscle movements four basic natural emotional expressions angry happy sad fear high fidelity results perceiving realistic facial expression virtual human emotions based facial skin color texture may contribute towards development virtual reality game environment computer aided graphics animation systems graphical abstract realistic facial expressions avatar graphics
vitamin liposoluble vitamin predominant dietary form phylloquinone vitamin found plants green vegetables whereas menaquinone vitamin endogenously synthesized intestinal bacteria includes several subtypes differ side chain length aside established role blood clotting several studies support critical function vitamin improving bone health vitamin fact required osteocalcin carboxylation turn regulates bone mineral accretion seems promote transition osteoblasts osteocytes also limits process osteoclastogenesis several observational interventional studies examined relationship vitamin bone metabolism findings conflicting unclear systematic review aims investigate impact vitamin plasma levels dietary intake oral supplementation bone health particular interest bone remodeling mineral density fragility fractures elsevier inc rights reserved
paper presents novel control method based predictions neural network coordination conventional pid control improve transient characteristics digitally controlled switching converters power supplies communication systems require achieve superior operation electronic equipment installed especially important improve transient characteristics required conditions since affect operation power supplies therefore converters power supplies need superior control method suppress transient undershoot overshoot output voltage presented method neural network trained predict output voltage adopted modify reference value pid control reduce difference output voltage desired one transient state transient characteristics gradually improved training procedure neural network proceeded repetitively furthermore timing duration neural network control also investigated devised since time delay one main issue digital control methods affects improvement transient characteristics repetitive training duration adjustment neural network performed simultaneously obtain improvement transient characteristics simulated experimental results confirmed presented method realizes superior transient characteristics compared conventional pid control
studies violence digital games investigated effects arousal aggression little attention paid game violence actually perceived evaluated investigate issue conducted two experimental studies participants either played watched violent shooter game reported perceived evaluated violent content results showed playing games led increased awareness game violence also less negative subjective evaluations violent content gaming frequency negative effect perception evaluation game violence suggesting desensitization effect results studies illustrate individual perceptions evaluations violence digital games taken account studying effects implications research system age ratings discussed based findings
parkinson disease characterized loss dopaminergic neurons substantia nigra previous study demonstrated kukoamine exhibit strong neuroprotective effects anti oxidative stress anti inflammation anti excitoxicity present study mpp mptp induced models cell animal used investigate effects kua results demonstrated kua ameliorated cell loss mitochondrial membrane potential mmp loss inhibited bax bcl ratio mapks family induced mpp addition animal experiments showed kua improved motor function neuronal activity increased positive cells tyrosine hydroxylase substantia nigra striatum str moreover kua could decrease expression alpha synuclein brain finally kua exerted apparent autophagy enhancement vitro vivo conclusion kua protected neurotoxin induced due apoptosis inhibition autophagy enhancement suggesting kua treatment might represent neuroprotective treatment elsevier ltd rights reserved
purpose prevalence intimacy substance use among adolescents young adults cancer therapy well described methods resilience adolescents young adults cancer study prospective multicenter mixed methods cohort study english speaking patients years old newly diagnosed cancer invited complete comprehensive survey time enrollment months later intimate relationships health behaviors assessed questions adapted guidelines adolescent preventative services assessment descriptive statistics characterized prevalence sexual substance related behaviors time point results eligible enrolled participants completed surveys respectively mean age years standard deviation male common diagnoses sarcoma acute leukemia third participants reported dating time point sexually active endorsing sexual activity fewer half reported consistent birth control condom use reported first sexual intercourse observation addition reported alcohol use reported illicit drug use despite activities fewer endorsed worry need discuss behaviors oncology providers conclusions intimacy substance use among adolescents young adults common cancer therapy clinical research implications include identification optimal communication patient centered supports society adolescent health medicine rights reserved
energy one important categories green building rating systems world green building building meets energy requirements present low energy consumption investment costs without infringing rights forthcoming generations find needs despite qualified rating system clear system different priorities needs accordingly paper proposes methodology using analytic hierarchy process ahp assessment energy credits studying comparing four common global rating systems british building research establishment environmental assessment method breeam american leadership energy environmental design leed australian green stars pearl assessment system united arab emirates order contribute enhancement egyptian green pyramid rating system gprs results show mandatory optional energy credits considered proposed weights according present future needs green egypt results compared data gathered desk studies results extracted recent questionnaires elsevier ltd rights reserved
buckypapers free standing porous mats entangled cnt ropes cohesively bounded van der waals interactions used monitor manufacturing process glass fiber reinforced composite paper buckypaper fabricated monodispersion multi wall carbon nanotubes via spray vacuum filtration morphology pore size distribution characterized scanning electron microscope nitrogen adsorption desorption resistance sensor obtained using four point probe method resistance changes could related phase changes resin matrix experimental results show sensor embedded glass epoxy composite laminates indicated relative resistance change manufacturing process addition temperature sensitivity pristine sensor sensor embedded composite also characterized results demonstrate effect resin phase changes resistance changes sensor greater temperature composite manufacturing elsevier ltd rights reserved
novel nonparametric system identification algorithm described focusing pid based control loops buck converters effective series resistance esr output filter dithering amplification effects control path exploited steady state converter operation noise injected used stimulate loop reaction identify output filter configuration oversampling dithering features third order delta sigma modulators used increase dpwm resolution converter nominal operation moreover core key compute algorithm modified structure noise shaper used handle resolution algorithm range desired frequencies nonparametric identification algorithm comprises two steps first processing step extracts resonant frequency second extracts esr zero power spectrum density computation control feedback error method validated different buck converter configurations successfully integrated measured digitally controlled buck converters prototype automotive safety application
vitamin antagonists vkas mainstay anticoagulation therapy years vkas mainly used prevention stroke patients atrial fibrillation treatment secondary prevention venous thromboembolism past years four new agents direct factor inhibitors apixaban edoxaban rivaroxaban direct thrombin inhibitor dabigatran collectively known direct oral anticoagulants doacs non vka oral anticoagulants approved indications despite new treatment options vka warfarin currently remains frequently prescribed oral anticoagulant availability doacs provides alternative management option patients especially treating physician hesitant prescribe vka owing associated limitations food drug interactions concerns bleeding complications currently available real world evidence shows doacs similar improved effectiveness safety outcomes compared warfarin treatment decisions doac best suited patient maximize safety effectiveness take account clinically relevant patient characteristics also patient preference article reviews highlights real perceived implications vkas prevention stroke patients non valvular specific reference strengths weaknesses compared doacs
objective describe clinical features dogs diagnosed stromal intracorneal hemorrhage ich animals studiedretrospective case series dogs eyes ich procedures medical records dogs evaluated cornell university ophthalmology service searched identify animals clinical diagnosis ich signalment clinical details including concurrent ocular disease concurrent systemic disease diagnostic tests performed outcome hemorrhage presenting client complaint treatment recorded results intracorneal hemorrhage identified eyes dogs mean standard deviation age dogs years years bichon frise breed older dogs statistically represented relative entire ophthalmology service canine referral population time period concurrent ocular disease present eyes included keratoconjunctivitis sicca cataracts corneal ulcers twenty three dogs suffered concurrent systemic disease frequently diabetes mellitus hyperadrenocorticism hypothyroidism systemic hypertension less commonly life threatening systemic conditions identified dogs ich including immune mediated hemolytic anemia immune mediated thrombocytopenia metastatic neoplasia sepsis intracorneal hemorrhage found corneal locations corneal vascularization present affected eye conclusions intracorneal hemorrhage uncommon condition dogs occurs association corneal vascularization risk ich may increased due certain ocular systemic diseases although uncommon ich may also ocular manifestation severe immune mediated infectious neoplastic systemic diseases dogs
lean design product design philosophy aims drive resource waste factory floor using efficient design munro provides data show lean design greatest impact efficient workings manufacturing operation lean design influences floor space labor raw material quality ultimately profits manufacturing company paper companies pursue lean design utilizing geometric dimensioning tolerancing target manufacturing zero tolerancing maximum material virtual condition mmvc shown although concepts available different places within quality texts connection eludes educators students concepts utilized manufacturing companies strategic tools better communicate product design manufacturing personnel presented important include concepts lean design product design manufacturing engineering curriculum also explained
previous studies posture parkinson disease patients focused pathophysiology severe deformities using mainly subjective estimations goniometric measures aim study investigate risk factors associated flexed posture effects course posture variations one hundred ninety patients definite prospectively evaluated angles spinal inclination upright position extension flexion using mechanical computer assisted hand held device spinalmouse patients underwent clinical examination including background data bone mineral density motor function evaluated updrs back pain rmdq physical activity data collected self report postural measurements repeated months angle upright inclination correlated age older age disease onset longer disease duration higher updrs motor posture score presence back pain osteoporosis correlation upright angle inclination gender disease type side disease onset evaluation posture patients months initial evaluation showed significant deterioration forward bending significantly associated disease duration worsening updrs score right side disease onset presence vertebral fractures lack physical activity older age disease severity duration presence back pain osteoporosis associated postural abnormalities physical activity might slow worsening postural abnormalities
aims study looks connection parents substance abuse years old children somatic psychological health methods retrospective population based cohort study based finnish health care social welfare registers participants children born finland biological parents children followed hospitalisations injuries somatic illness psychiatric disorders association hospitalisations parents substance abuse well living abusing parent estimated using logistic regression findings children hospitalisations reasons prevalent mother father substance abuse problem mother substance abuse increased children risk hospitalisations somatic illness psychiatric disorders father substance abuse increased risk hospitalisation psychiatric disorders risks even higher parents substance abusers conclusions parents substance abuse cause variety harms children may related unsafe environment long standing stress non adequate responding child needs multi professional work substance abusing parents children crucial order reduce children risks poor health
recent field work wax lake delta wld coastal louisiana indicates lateral outflow channels islands upstream receiving basin region delta flow transitions confined unconfined uniform discharge profile nonuniform discharge profile hydraulics transition zone controls exerted vegetation topography river discharge fluctuations analyzed work shallow water equations numerically solved two model domains idealized channel island complex full domain wld domains significant fraction river discharge flows laterally channels deltaic islands reaching receiving basin vegetation roughness within delta islands significantly impacts fraction rate lateral outflow channel river discharge fluctuations limited effect due backwater control subcritical flow presence vegetation islands tends increase velocities within channel except region upstream significant lateral outflow velocity increases decreasing vegetation roughness due lowered water level reduces flow cross section topography establishes lateral water surface gradient channel islands even low vegetation roughness drives lateral flow velocity spreading angle used mark transition confined unconfined flow angle generally increases onset unconfined flow decreases flow approaches receiving basin flow island tends align channel lateral outflow primary channels influences hydraulics flow throughout backwater length transition confined unconfined flow coastal river deltas significant impact flow hydraulics resulting transport dynamics solids solutes american society civil engineers
broad autism phenotype bap individual difference whereby persons exhibit mild characteristics autism spectrum disorder asd including socially aloof rigid personality given individuals high bap rigidity difficulty adjusting change present research examined whether rigid persons report greater concerns death adhere cultural beliefs following mortality salience study found bap rigidity positively associated greater mortality related concerns study high rigid individuals evidenced increased death thought accessibility following finally study found led heightened worldview defense individuals high rigidity decreasing defensiveness low rigidity results provide evidence moderating role individual differences terror management effects specifically asd characteristics young adults particularly area rigidity contribute heightened death concerns greater defensiveness elsevier ltd rights reserved
paper discusses key issues acceptable approaches environmental management construction industry author approach relies cluster analysis structural components construction subject technological specific features construction works providing construction operations form multifaceted set activities construction project unique terms climatic conditions natural environments geographic coordinates front end engineering stage object lifecycle include simulation potential emergency situations apart building computer models target construction object allows evaluating extent environmental impact construction project case accidents may occur construction operation phases structural greening become vital aspect stage building lifecycle structural greening specific flows help deliver environmental compliance indices considered determination duration specific flow construction project whole authors published elsevier ltd
paper embedded control system developed measure yield strength material plate applied load systematic approach proposed handle special requirements embedded control systems different computer based control systems much less hardware resources computational power available efficient control algorithm designed remove cpu burden microcontroller enough power available three step approach proposed address embedded control issue firstly mathematical description whole system studied using theoretical experimental methods mathematical model derived physical models component used experiment retrieved employing levy method least square estimation identify specific parameters system model secondly feedforward plus feedback controller designed simulated preparation embedded system implementation cerebellar model articulation controller cmac chosen feedforward part controller used feedback part train cmac finally proposed algorithm applied embedded system experiments conducted verify identified model designed controller
magnetic shape memory alloys msmas type smart material exhibit large amount recoverable strain subjected applied compressive stress presence magnetic field applied magnetic field presence compressive stress macroscopic recoverable strains result orientation tetragonal martensite variants potential applications msmas include power harvesters sensors actuators applications stress assumed applied axial direction magnetic field assumed applied transverse direction realize full potential msma optimize designs mathematical model predict material response potential loading conditions needed keifer lagoudas developed phenomenological model characterizes response msma axial compressive stress transversely applied magnetic field based thermodynamic principles paper similar thermodynamic framework isused however simpler hardening function proposed based observation orientation phenomenon forward reverse loading well magnetic mechanical loading magnetic domains redefined accurately reflect magnetic field measured experiment ally revised model shown adequately predict magneto mechanical response msma loading axial compressive stress transversely applied magnetic field
important yet untested assumption within personality psychology important person characteristics densely reflected language investigated ratings importance term properties associated one another term frequency use research participants asked provide terms described individuals knew resulted set adjectives terms independently rated importance social desirability observability stateness versus traitness level abstraction base rate terms rated describing important person characteristics fact used often participants sample large corpus online communications close million words frequently used terms positive terms also rated abstract traitlike widely applicable greater base rate discuss implications findings regard person perception general
paper new cmos four quadrant analog multiplier circuit proposed based pair dual translinear loops significant features circuit high accuracy high linearity well body effect free operation owing fact circuit relies new dual translinear topology addition harmonic distortions precisely discussed due conceivable mismatches including transconductance threshold voltage transistors hspice postlayout simulation results presented verify validity theoretical analysis supply voltage bandwidth proposed multiplier mhz corresponding maximum linearity error remains low moreover power dissipation proposed circuit found presented multiplier expected useful design various analog signal processing applications modulators frequency doublers illustrated paper
interleukin anti inflammatory cytokine controls inflammation inhibiting synthesis several cytokines produced cells macrophages association interleukin promoter polymorphisms risk multiple sclerosis remains inconclusive study meta analysis performed assess relationship gene polymorphisms risk nine case control studies selected involving participants association polymorphisms examined pooled odds ratios ors confidence intervals cis allelic homozygote heterozygote dominant recessive genetic models analyzed genetic models pooled ors cis snps calculated based random fixed effects genetic predisposition susceptibility across asian caucasian populations addition assessment based funnel plot egger linear regression test suggests publication bias analyzed genetic models overall results demonstrated polymorphisms may risk factor development populations elsevier rights reserved
emergence cloud computing paradigm greatly enabled innovative service models platform service paas distributed computing frameworks mapreduce however existing cloud systems fail distinguish users different preferences jobs different natures consequently unable provide service differentiation leading inefficient allocations cloud resources moreover contentions resources exacerbate inefficiency prioritizing crucial jobs necessary impossible motivated propose abacus generic resource management framework addressing problem abacus interacts users auction mechanism allows users specify priorities using budgets job characteristics via utility functions based information abacus computes optimal allocation scheduling resources meanwhile auction mechanism abacus possesses important properties including incentive compatibility users best strategy simply bid true budgets job utilities monotonicity users motivated increase budgets order receive better services addition user unclear utility function abacus automatically learns function based statistics previous jobs extensive experiments running hadoop private cluster amazon demonstrate high performance desirable properties abacus elsevier rights reserved
prenatal exposure perfluoroalkyl acids pfaas influences fetal growth long term health however whether pfaas affect offspring dna methylation patterns influence health outcomes yet evaluated assessed effect prenatal pfaa exposure cord blood insulin like growth factor igf long interspersed element line methylation associations birth size mother child pairs hokkaido study environment children health included study perfluorooctane sulfonate pfos perfluorooctanoic acid pfoa levels maternal serum measured liquid chromatography tandem mass spectrometry igf line methylation cord blood dna determined pyrosequencing full adjustment multiple linear regression models igf methylation showed significant negative association log unit increase pfoa partial regression coefficient confidence interval mediation analysis suggested reduced igf methylation explained similar observed association pfoa exposure reduced ponderal index infant birth results indicated effects prenatal pfoa exposure could mediated dna methylation study required determine potential long term adverse health effects reduced igf methylation induced pfoa exposure
energy use efficiency energy consumption rates center pivot irrigation systems utmost importance scientific community numerous studies addressed different approaches achieve greatest energy use efficiency encountered problems due lack detailed field information study introduces approach reduce energy consumption center pivot irrigation varying pump power supply speed using variable frequency drive vfd technology varying frequency power supply minimum required pivot point pressure provided required flow rate position field model developed using high resolution digital elevation model dem datasets geographic information system gis simulate minimum pressure required standard equipped randomly selected pivots located ten nebraska counties variable topography within individual field played important role determining required pressure thus energy consumption resulting energy reduction using variable speed motor approach calculated center pivot irrigated field average pivots cedar county showed largest potential energy reduction also contained largest elevation difference pivot point highest point traversed pivot tower contrast pivots hamilton county showed low potential energy reduction contained smallest average elevation difference determine potential economic benefit variable speed motor approach annual monetary savings calculated installation county pivots custer county would gain greatest annual returns average due relatively long hours operation whereas pivots hamilton county would achieve negligible savings due gentle topography hours operation county average payback period capital cost vfd found exceed economic life vfd ten counties
two stage core analysis method widely used bwr core analysis purpose study develop core analysis model coupled subchannel analysis within two stage calculation scheme using assembly based thermal hydraulics calculation core analysis model changes lattice physics scheme couples subchahnel analysis evaluates thermal hydraulics characteristics within coolant flow area divided subchannel regions order couple two analyses bwr fuel assembly parameters assumed verified developed model evaluated heterogeneous problem without control rod present model especially effective control rod inserted condition present model incorporate subchannel effect current two stage core calculation method elsevier ltd rights reserved
growing body evidence suggesting nonpharmacological interventions appropriate place treatment major depressive disorders mdds stand alone supplemental treatments women may reluctant use psychotropic medications due strong values treatment preferences specific reproductive events clinicians need able offer empirically based alternatives medication review present recent findings studies acupuncture bright light therapy electroconvulsive therapy omega fatty acid supplementation physical activity psychosocial intervention women experiencing depressive symptoms contexts menstruation pregnancy postpartum menopause
achieve neuronal differentiation mouse bone mesenchymal stem cells bmscs neuron like cells explore role mir may regulate box brain tbr expression induction bmscs cultured induced butylated hydroxyanisole retinoic acid basic fibroblast growth factor nerve growth factor vitro cells stained neuron specific enolase nse beta iii tubulin immunocytochemistry immunofluorescence mir may regulate tbr expression predicted bioinformatics identified using dual luciferase assay expressions mir tbr determined real time pcr western blot induction infection mir expressions tbr nse tauons measured bmscs showed short spindle shape uniform distribution days induced cells showed neuronal traits pyramidal appearance targetscan miranda showed mir well complementary target site tbr untranslated region identified dual luciferase assay found mir could inhibit tbr expression binding untranslated region furthermore expressions tbr mrna protein decreased real time pcr western blot overexpression mir downregulated expressions tbr nse tauons mir may negatively regulate tbr expression affect differentiation bmscs neuron like cells copyright author published wolters kluwer health inc
present high voltage cmos neural interface chip multichannel vestibular prosthesis mvp measures head motion modulates vestibular nerve activity restore vision posture stabilizing reflexes application specific integrated circuit neural interface asic chip designed work commercially available microcontroller controls asic via fast parallel interface deliver biphasic stimulation pulses bit programmable current amplitude via stimulation channels chip fabricated onsemi micron high voltage cmos process accommodate compliance voltages stimulating vestibular nerve branches using biphasic current pulses durations short phase asic includes dedicated digital analog converter channel enabling perform complex multipolar stimulation asic replaces discrete components cover nearly half generation mvp mvp printed circuit board reducing mvp system size power consumption physiological tests asic based mvp system mvpa rhesus monkey produced reflexive eye movement responses prosthetic stimulation similar observed using mvp sinusoidal modulation stimulus pulse rate pulses per second frequencies elicited appropriately directed slow phase eye velocities ranging amplitude degrees mvp mvpa eye velocities evoked mvp mvpa showed significant difference test suggesting mvpa achieves performance least good larger mvp
role arboviruses causing acute febrile illness sub saharan africa receiving attention reports dengue tourists published nearly years ago namibia current epidemiology arboviruses unknown surveys mosquito vectors carried since begin addressing knowledge gap prospective cross sectional study conducted using samples volunteer blood donors linked questionnaire serum samples tested using dengue igg indirect elisa measured exposure dengue virus flaviviruses entomological samples collected tires rainy season february march six locations across namibia capital city windhoek among blood donors tested positive dengue virus flavivirus exposure significant risk factor age group high exposure rates among older compared years old larvae pupae aedes aegypti culex pipiens complex accounted samples collected aegypti site demonstrated high variability species composition sampling times significant dengue virus flavivirus exposure rate among years old likely indicative west nile epidemic low exposure among suggests flaviviruses still circulating namibia aegypti pipiens may play role future epidemics significance presence may reduced due short rain periods dry arid cold winters policies social understandings limit non structured storage use tires low income areas future studies characterize circulating arboviruses investigate mosquito ecology nationally map areas higher risk future arbovirus outbreaks elsevier rights reserved
objective computed tomography use among patients present emergency departments eds rhinosinusitis symptoms well described aim describe sinus utilization patterns identify predictors use hypothesize patient symptoms socioeconomic factors gender may influence decision obtain sinus scan study design retrospective review methods nationwide emergency department sample queried patient encounters primary diagnosis sinusitis international classification diseases ninth revision clinical modification codes patient demographics comorbidities disposition obtained factors associated scan use determined univariable multivariable logistic regression results total visits attributed primary diagnosis sinusitis majority patients adult age female computed tomography imaging obtained patients univariable analysis many socioeconomic factors predictive imaging including private insurance metropolitan patient residence higher median household income quartile strongest predictors use multivariable analysis history injury odds ratio confidence interval headache northeast hospital location midwest male gender conclusions several socioeconomic demographic geographic factors associated sinus scan use rhinosinusitis study implications imaging guidelines setting demonstrates need investigation healthcare utilization disparities
parallel version nemo complex ocean circulation model implemented black sea basin results circulation numerical modeling high spatial resolution presented analysis spatial variability performed reconstructed hydrophysical fields resulting simulated spatial variability characteristics sea surface temperature compared available satellite observational data
dodd hristopoulos scharfstein brower hassoun king becker liu wang hassoun rabb interactive effects mechanical ventilation kidney health lung function vivo mouse model physiol lung cell mol physiol first published october doi ajplung hypothesized influence acute kidney injury aki sensitivity lung injurious process varies severity injurious process thus thought aki would exacerbate lung injury low degrees lung trauma attenuate lung injury higher degrees lung trauma cbl mice underwent aki min kidney ischemia sham surgery followed spontaneous breathing mechanical ventilation low tidal volume ltv mechanical ventilation high tidal volume htv compared ltv median bronchoalveolar lavage bal protein leak significantly lower greater htv sham aki mice compared ltv median evans blue dye labeled albumin extravasation lungs ebd also significantly lower greater htv ebd showed significant interaction ventilatory mode kidney health aki attenuated ebd rise seen htv ltv sham mice interaction ventilatory mode kidney health could also seen bal neutrophil number pmn thus aki attenuated bal pmn rise seen htv ltv sham mice data support presence complex interaction mechanical ventilation aki sensitivity lung trauma varies magnitude trauma may involve modification pulmonary neutrophil activity aki
paper presents identification method dynamic systems based group method data handling approach particular new structure dynamic multi input multi output neuron state space representation proposed moreover new training algorithm neural network based unscented kalman filter presented final part work contains illustrative example regarding application proposed approach robust fault detection tunnel furnace
previously developed gelatin silk fibroin microspheres loaded curcumin applied anti inflammatory treatment monosodium iodoacetate mia induced osteoarthritis rat model mia induced rats received single intra articular injection gelatin gelatin silk fibroin microspheres encapsulating curcumin therapeutic effects treatment groups concentration interleukin blood serum radiographic histological grading articular joint compared normal saline treated normal rats result showed microsphere groups reduced level serum week treatment gelatin silk fibroin microspheres encapsulating curcumin delayed cellular destruction articular joint synovial tissue weeks radiographic histological gradings articular cartilage lesion synovial tissue change rats treated gelatin silk fibroin microspheres encapsulating curcumin close normal rats explained slow degrading gelatin silk fibroin microspheres released curcumin extended period showed prolonged anti inflammatory effect compared fast degrading gelatin microspheres delivery system curcumin suggested applied localized treatment anti inflammatory minimal invasion
background abnormal savda munziq asmq traditional prescription uyghur medicine treatment complex diseases tumors asthma proven effective uyghur medical clinical practice efficacy enhancing toxicity reducing properties asmq studied mice transplanted cervical cancer tumors treated fluorouracil work methods investigate synergistic effect asmq cells inhibitory effects cell proliferation determined mtt assay kunming mice randomly divided groups control group model group group combine asmq low dose group combine asmq medium dose group combine asmq high dose group inhibition rate tumor viscera indexes content serum tumor necrosis factor alpha tnf alpha alanine aminotransferase alt aspartate aminotransferase ast determined expression levels transforming growth factor beta tgf beta human papillomavirus type hpv protein assessed western blot pathological changes liver observed result inhibition rates tumors asmq group asmq group asmq group group clearly indicated effects tumor inhibition thymus index spleen index increased serum concentration tnf alpha increased alt ast concentrations decreased tnf alpha protein expression increased tgf beta hpv decreased asmq might improve livers central vein hyperemia interstitial edema preserve radial structure hepatic cords conclusions results suggested asmq might reduce toxicity enhance efficacy chemotherapeutic drug fluorouracil treatment cervical carcinoma
background dermatophytosis common superficial fungal infection keratinised tissues like skin hair nail present study aimed determine clinical pattern dermatophytes north kerala common species prevalent area materials methods laboratory clinical data patients cutaneous infection collected subjected standard mycological techniques results total samples taken showed positive culture tinea corporis commonest clinical type trichophyton rubrum predominant species isolated conclusion prevalence dermatophytosis varies geographical location age group affected aetiological agents also depend upon site infection various factors
introduction depression disorder may become first cause morbidity according world health organization actually one main causes disease handicap children aged major risk suicide whose prevalence estimated france around probably underestimated present discussions prescription antidepressants adolescent depression remain intense psychotherapy becomes first choice treatment propose present one interpersonal psychotherapy ipt remains largely unknown france adaptations adolescent population presentation ipt ipt brief psychotherapy structured twelve sixteen sessions created klerman weissman seventies inspired biopsychosocial model meyer interpersonal theory sullivan attachment theory bowlby divided three parts initial phase intermediate phase termination phase adaptation adolescents ipt adapted adolescents mufson modifications must considered parental implication first indeed parents rather adolescent often ask consultation latter benefits therapy parents may met point therapy example phase end initial phase close adolescent adult therapist must careful employing sick role used adolescent avoid school consequence exacerbate interpersonal deficit intermediate phase focuses one four interpersonal issues complicated bereavement role transition interpersonal role disputes interpersonal deficit complicated bereavement may become problematic prolonged adolescent complicated relations deceased therapist essentially works emotion verbalization role transition common adolescence children become adults pass high school college parents get divorced etc patient therapist work giving old role emotional expression guilt anger loss acquiring new skills identifying positive aspects new role interpersonal role disputes common adolescence parents teachers example determine treatment plan therapist may first determine stage role dispute among impasse renegotiation dissolution work communication mode patient least interpersonal deficit may difficult area work risk psychiatric comorbidity therapist must especially careful anxious disorder may complicate psychotherapy ipt best therapy termination phase focuses new skills abilities works future without therapy ipt one psychotherapies recommended treatment depression disorder international recommendations france psychotherapies considered equally may consensual approach authors wonder best especially motivate research psychotherapy field indications finally ipt developed indications past years many others presently research projects depression pregnancy prevention depression relapse eating disorders attention deficit hyperactivity disorder self harm example conclusion validity simplicity efficacy stimulate psychiatrists residents train ipt encephale paris
method computation inverses given matrix derived based full rank decomposition appropriate matrix corollary new method considering advantages full rank decomposition developed specialized set polynomial matrices therefore algorithm efficient symbolic computation inverses polynomial matrix proposed additional diagonal matrix yields avoiding computation entries containing square roots polynomials therefore increasing algorithm performances implementation details comparative processing times similar methods provided illustrating algorithm efficiency
adjuvant chemotherapy important component treatment gastric cancer patients however patients respond drugs aimed develop practical profile based serum micrornas mirnas used predict patients likely respond treatment microarrays used screen cisplatin resistant sgc ddp cells parental sgc cell lines mirnas related chemotherapy sensitivity correlation expression patterns identified serum mirnas overall survival confirmed patients furthermore also validated signature serum mirnas independent cohort patients screening microarrays focused mir mir mir downregulated mirnas sgc ddp cells mir mir mir upregulated mirnas serum mir mir mir mir useful predicting prognosis patients received adjuvant chemotherapy identified signature four serum mirnas mir mir mir mir combined used risk score overall survival patients higher risk score worse prognosis independent cohort patients signature four mirnas predicted prognosis well data showed risk score derived four serum mirnas closely associated overall survival patients received adjuvant chemotherapy
multiple instance learning aims identifying underlying concept collectively labeled data training sample consists set known bag unlabelled instances bag whole labeled positive least one instance bag positive negative otherwise given training samples goal learn description common instance among positive bags underlying concept responsible positive label work introduce learning scheme based notion partial entropy concept learning partial entropy accentuates intra class information focusing information reflected positive class proportion total entropy maximization equalize likelihoods intra class outcomes among positive class essentially reflecting intended concept coupled distance based probabilistic model learning equivalent seeking concept estimate equalizes intra class distances distance negative bags restrained produces patterns similar least one instance positive bags dissimilar instances negative bags generated patterns optimization process correspond prototypical concepts maximum partial entropy conceptually simple experimental results different datasets demonstrate effectiveness learning explicit representation concept competitive performance applied classification tasks
psychological research prejudice homosexuals distinguishes old fashioned traditional modern contemporary homonegativity differ regard content correlates consequences current research offers evidence validity old fashioned versus modern homonegativity distinction post communist east european context studies respectively polish adaptations non gendered gendered homonegativity scale morrison parriag morrison modern homonegativity scale morrison morrison developed furthermore divergent discriminant validity traditional contemporary anti homosexual prejudice demonstrated old fashioned modern homonegativity exhibited differential relationships social distance support sex couples relational rights
renal ischemia reperfusion one main causes acute kidney injury aki usually occurs clinical surgery autophagy plays important role recovery acute ischemic kidney injury microrna mir reported inhibit autophagy several diseases however molecular mechanism mir autophagy renal still unclear vitro study nrk cells transfected mir mimics subjected results showed mir mimics inhibited cell viability induced cell apoptosis nrk cells expression beclin induced decreased mir mimics inhibited induction pcr western blotting assay showed mir mimics inhibited protein level raba mrna level luciferase activity assay showed mir directly targeted raba raba overexpression attenuated effect mir mimics cell viability cell apoptosis expression beclin increased decreased raba overexpression vivo assay rat model mir level increased renal injury pre treatment mir inhibitor injection attenuated renal injury enhanced expression beclin results showed mir inhibited autophagy targeting raba renal indicating raba might new medical target treatment renal elsevier inc rights reserved
global tractography estimates brain connectivity organizing signal generating fiber segments optimal configuration best describes measured diffusion weighted data promising better stability local greedy methods respect imaging noise however global tractography computationally demanding requires computation times often prohibitive clinical applications present reformulation global tractography algorithm fast parallel implementation amendable acceleration using multi core cpus general purpose gpus method motivated key observation fiber segment affected limited spatial neighborhood words fiber segment influenced fiber segments potentially connected two ends also diffusion weighted signal proximity observation makes possible parallelize markov chain monte carlo mcmc algorithm used global tractography algorithm concurrent updating independent fiber segments carried experiments show proposed algorithm significantly speed global tractography time maintain even improve tractography performance
aimthe aims trial follows compare cost effectiveness turning repositioning system algorithm tailored repositioning usual care improve reposition frequency patients risk compare cost effectiveness standardized incontinence care usual care backgroundpressure ulcers serious common problem hospitalized patients many countries pressure ulcers recognized national health issue governments designate pressure ulcers one important sentinel events health care international guidelines recommend use pressure redistributing support surfaces systematic patient repositioning preventive skin care prevent pressure ulcers interventions patient tailored based thorough assessment patient contextual risk factors lack rigorous research addressing effectiveness turning repositioning system unclear tailor frequency posture specific patient needs designmulticentre cluster three arm randomized controlled pragmatic trial cost effectiveness analysis ward unit randomization methodstailored repositioning use device facilitate patient repositioning optimal procedure incontinence care combined participating wards intensive care units geriatric rehabilitation wards sample size calculation performed power study approved ethics committee february discussiondata collection currently ongoing results expected obtained march
article new formula expressing explicitly squares jacobi polynomials certain parameters terms jacobi polynomials arbitrary parameters derived derived formula given terms ceratin terminating hypergeometric function type cases reduced using well known reduction formulae literature watson pfaff saalschiitz identities cases reduced means symbolic computation particular zeilberger petkovsek van hoeij algorithms hence new squares formulae jacobi polynomials special parameters deduced reduced forms free hypergeometric functions
background multiple epidemiological studies shown low testosterone levels associated predict future development type diabetes mellitus metabolic syndrome aim study show influence testosterone replacement therapy obesity hbac level hypertension dyslipidemia patients diabetes mellitus androgen deficiency methods one hundred twenty five male patients diabetes mellitus screened subjects aged years bmi randomized placebo controlled study also underwent routine physical examination selected free testosterone examination divided patients two groups treatment group used diet physical activity patient antidiabetic therapy testosterone replacement therapy placebo group used diet physical activity patient antidiabetic therapy placebo results months treatment repeated diagnostic assessments lipid profile improved groups first group clinically significant free testosterone level increased groups group clinically significant hbac decreased groups group obtained best result leptin level treatment approximately groups also blood pressure reduced groups results similar conclusions study demonstrated possible break metabolic vicious circle raising testosterone levels diabetic men androgen deficiency instituting physiological levels testosterone study shown important role reducing prevalence diabetic complications
due rise social economic costs depression new antidepressant medication fewer side effects found several studies shown association exists omega polyunsaturated fatty acids omega pufas depression however association clear enough elderly mild moderate depression sixty six inhabitants kahrizak charity foundation participated double blind randomized placebo controlled study participant parts per thousand yen years age mini mental state exam parts per thousand yen scores ranging geriatric depression scale gds months drug group treated daily one gram fish oil capsule containing eicosapentaenoic acid docosahexaenoic acid significant differences noted groups regard level education use antidepressant drugs alcohol tobacco use history chronic diseases age body mass index bmi high sensitive reactive protein crp total cholesterol gds scores baseline adjusting cholesterol bmi history thyroid dysfunctions statistically significant difference seen gds scores groups furthermore treatment omega pufas clinically effective treating depression comparison placebo study low dose omega pufas efficacy treatment mild moderate depression elderly participants
presence emerging contaminants pharmaceuticals natural waters raised increasing concern due frequent appearance persistence aquatic ecosystem threat health safety aquatic life even trace concentrations conventional water treatment processes known generally inadequate elimination persistent contaminants therefore use advanced oxidation processes aops able efficiently oxidize organic pollutants attracted great amount attention main limitation aops lies high operating costs associated consumption energy chemicals fenton based processes utilize nontoxic common reagents potentially exploit solar energy considerably reduce removal cost recalcitrant contaminants disadvantages homogeneous fenton processes generation high amounts iron containing sludge limited operational range prompted much attention use heterogeneous fenton processes review impacts controlling parameters including catalyst dosage solution initial contaminants concentrations temperature type catalyst intensity irradiation reaction time feeding mode removal efficiencies hetero homogeneous fenton processes discussed addition combination fenton type processes biological systems pre post treatment stages pilot scale operations considered reported experimental results obtained using fenton photo fenton processes elimination pharmaceutical contaminants also compiled evaluated elsevier ltd rights reserved
energy prediction machine tools deliver many advantages manufacturing enterprise ranging energy efficient process planning machine tool monitoring physics based energy prediction models proposed past understand energy usage pattern machine tool however uncertainties machine operating environment make difficult predict energy consumption target machine reliably taking advantage opportunity collect extensive contextual energy consumption data discuss data driven approach develop energy prediction model machine tool paper first present methodology efficiently effectively collect process data extracted machine tool sensors present data driven model used predict energy consumption machine tool machining generic part specifically use gaussian process regression nonparametric machine learning technique develop prediction model energy prediction model generalized multiple process parameters operations finally apply generalized model method assess uncertainty intervals predict energy consumed part machine using mori seiki nvd machine tool furthermore model used process planning optimize energy efficiency machining process
background several articles phd trainees basic sciences published past several years little research exists physician investigators social sciences humanities however numbers phds training fields number programs offering training fields increasing particularly within addition accountability public funding phd programs requires knowledge growing population trainees career trajectories aim paper describe first cohorts phds social sciences humanities characterize training career paths better understand experiences training subsequent research practice methods paper utilizes multi pronged recruitment method novel survey instrument examine understudied population phd trainees social sciences humanities many completed degrees without formal programmatic support survey instrument designed collect demographic training career trajectory data well experiences perspectives training career describes routes professional development characterizes obstacles predictors success explores career trends results average length time complete degrees years vast majority completed clinical residency almost engaged research vast majority employed academic institutions several others held leadership positions national international health organizations went private practice survey responses supply recommendations supporting current trainees well areas future research conclusions general phds social sciences humanities careers fit goals agencies providing public funding training physician investigators involved mutually informative medical research clinical practice teaching working improve responses social cultural political determinants health health care findings provide strong evidence continued improved funding programmatic support phd trainees social sciences humanities
based lax representation solve three coupled higher order nonlinear schrodinger equations achievement soliton solution formula means darboux transformation involvement multi parameters actually parameters two soliton solutions investigate soliton excitations collisions alpha helical proteins interspine coupling higher order virtue multi parameter management graphical simulation found elastic inelastic collisions take place suitable parametric conditions additionally exist three kinds shape changing collision patterns among three components inelastic collision single solitons occur two different manners enhancement suppression intensity results multiparameter management analysis may give theoretical support well impetus experimental investigation soliton excitations elastic inelastic collisions alpha helical proteins interspine coupling higher order elsevier rights reserved
borderline personality disorder bpd characterized among symptoms interpersonal dysfunction difficulties empathizing according simulation theory empathy linked activity mirror neuron system mns rhythm desynchronization reflected suppression electroencephalographic alpha frequency bands provides non invasive electrophysiological window mns function analyzed desynchronization twenty two patients bpd twenty three matched healthy controls reward punishment sensitive action observation task addition examined empathy using interpersonal reactivity index bpd patients controls differ regard desynchronization entire time course compared however differences suppression groups occurred goal action became discernible correlations suppression empathy ratings emerged controls patient group findings suggest bpd patients generalized impairment mns activity though associations contextual factors seem plausible elsevier rights reserved
formulas incremental parallel computation second order central moments long known recent extensions formulas univariate multivariate moments arbitrary order developed formulas key importance scenarios incremental results required parallel distributed systems communication costs high survey recent results improve arbitrary order numerically stable one pass formulas extend weighted compound variants also develop generalized correction factor standard two pass algorithms enables maintenance accuracy nearly full representable range input avoiding need extended precision arithmetic empirically examine algorithm correctness pairwise update formulas order four well condition number relative error bounds eight different central moment formulas degree six address trade offs numerical accuracy speed various algorithms finally demonstrate use elaborate among mentioned formulas utilization compound moments practical large scale scientific application
background antibodies citrullinated proteins acpa common patients rheumatoid arthritis acpa appear disease onset target many self antigens citrullinated fibrin fibrinogen represents classical acpa target antigen mass spectrometry synovial fluid reveals elevated citrullinated cit fibrinogen fib peptides compared non controls investigated extent less studied peptides represent autoantibody targets sought visualize corresponding cit fib reactive cells patients methods house elisa established four cit fib alpha subunit peptides cit fib alpha cit fib alpha cit fib alpha cit fib alpha serum patients established disease controls psoriatic arthritis psa ankylosing spondylitis analyzed patients genotyped hla alleles ptpn screened anti ccp cit fib protein antibodies cit fib peptides also used assemble antigen tetramers identify cit fib reactive cells peripheral blood flow cytometry results frequencies autoantibodies different cit fib epitopes patients compared psa patients cit fib alpha psa cit fib alpha cit fib alpha cit fib alpha presence autoantibodies peptides associated presence anti ccp anti cit fib protein antibodies association found hla shared epitope antibodies different cit fib peptides however association observed ptpn risk allele positivity cit fib alpha cit fib alpha cells carrying surface reactive cit fib peptides found peripheral blood tend common ptpn risk allele carriers conclusions data show several cit fib peptides targeted autoantibodies psa implicating due arthritis specific etiology associated anti cit protein response broad many parallel immune responses association cit fib autoantibodies ptpn risk allele supports hypothesis altered cell regulation autoreactive cells evading tolerance checkpoints
objective study examines link marital disruption biological risk asks whether association precarious life event health contingent marital loss duration history method data drawn national social life health aging project poisson regressions presented allostatic load logistic regressions individual biomarkers results currently unmarried distant marital disruptions exhibit higher levels allostatic load currently married primarily driven dysregulation cardiovascular metabolic indicators results also reveal differing ways marital disruption gets skin widowhood associated compromised inflammatory metabolic cardiovascular functioning divorce cardiovascular neuroendocrine markers discussion findings lend support crisis chronic strain models likely reflect normative expectations timing life events decrements marital resources selection processes
epstein barr virus ebv major cause immunosuppression related cell lymphomas hodgkin lymphoma malignancies ebv latent membrane protein lmp lmpa provide infected cells surrogate cell receptor growth survival signals gain insights synergistic vivo roles germinal center cells ebv driven lymphomas arise generated mouse model conditional cell lmp lmpa coexpression lmp lmpa limited effects immunocompetent mice however upon cell depletion lmp caused massive plasmablast outgrowth organ damage death rna sequencing analyses identified ebv oncoprotein effects cell target genes including regulation multiple proinflammatory chemokines master regulators plasma cell differentiation lmp coexpression also regulated key markers including mixed hematopoietic lineage markers collectively results highlight synergistic ebv membrane oncoprotein effects cells provide model studies roles immunosuppression related lymphoproliferative diseases
article discusses development implementation daily money management dmm service within mature health social service agency although increasing recognition need dmm programs major obstacles development include problems securing adequate financial support concerns liability risks inherent providing financial services article describes innovative dmm service model developed senior health peer counseling santa monica california serviced elders first two years operation article explores mission key components organization service model including development multidisciplinary technical advisory group professionally supervised volunteer staff service planning care coordination issues risk management protocols need multiple sources financial support
paper describes implementation second order sliding mode sosm controller practical point load pol power supply realistic values output capacitor equivalent series resistance esr equivalent series inductance esl sosm control presented paper results fast transient responses current limiting feature supports light load operation achieves constant frequency steady state operation experimental results given input output prototype
background given predominance invasive fungal disease ifd amongst non immunocompromised adult critically ill population potential benefit antifungal prophylaxis lack generalisable tools identify high risk patients aim current study describe epidemiology ifd critical care units develop validate clinical risk prediction tool identify non neutropenic critically ill adult patients high risk ifd would benefit antifungal prophylaxis methods data risk factors outcomes ifd collected consecutive admissions adult general critical care units participating fungal infection risk evaluation fire study three risk prediction models developed model risk subsequent candida ifd based information available three time points admission critical care unit end end calendar day critical care unit stay final model time point evaluated three external validation samples results july april admissions critical care units recruited total admissions admitted developed candida ifd candida albicans rate candidaemia per admissions blood common candida ifd infection site initial potential variables final admission model model contained seven variables end calendar day model contained five variables end calendar day model performed best index full validation sample conclusions incidence candida ifd critical care units study consistent reports european epidemiological studies lower suggested previous hospital wide surveillance risk modeling using classical statistical methods produced relatively simple risk models associated clinical decision rules provided acceptable discrimination identifying patients high risk candida ifd
introduction eating disorder examination questionnaire ede widely used tool detect eating disorders aimed identify ede normative data among secondary school students kuala lumpur malaysia methods cross sectional study involving four secondary schools urban area respondents secondary school students selected using stratified sampling results teenagers years age participated study ede mean scores standard deviation total score global score restraint domain eating concern shape concern weight concern conclusion mean values obtained study relatively lower compared western populations shape concern weight concern higher scores compared domains values useful ede interpretation malaysia
introduction water used predominantly food manufacturing process northern morocco agro food industries use different sources water public water wells water main sources water used water main source possible food contaminations alterations study aims assess bacteriological quality water used agro food industries northern region morocco identify different types germs responsible pollution waters establish main causes pollution methods water samples taken taps wells analyzed detect pollution indicator germs total coliform fecal coliform intestinal enterococci revivable microorganisms sulphite reducing anaerobes pathogens salmonella staphylococci pseudomonas aeruginosa enumeration bacteria performed filtration technique incorporation obtained supercooled solid state results results showed public supply waters satisfactory bacteriological quality wells water non compliant water quality standards due presence pollution indicators contrast pathogens particularly salmonellae absent wells water analyzed conclusion well water pollution generally due failure meet hygienic requirements water pumping bacteriological quality wells water could improved adequate protection
paper describes novel sensorless identification method mechanical two mass systems influence varying parameters operation conditions performance identification procedure carried encoderless control drive system based frequency response measurement mechanical setup extended speed adaptive observer structure serves speed estimate calculation bode diagram extension observer structure speed estimation mechanical model allows reliable identification various two inertia systems within two identification steps paper gives overview new identification procedure results investigations toward robustness limitations varying speed load conditions well different parameterizations signal processing method underline applicability presented method
repeated chronic pressure eminent part body cause circulation disorder affected part body lack circulation result damage necrosis tissue phenomenon defined pressure sore due growth aging population chronic disease incidence prevalence rate creasing rapidly leads increased duration hospital stay medical expenditure hence prevention pressure sore appropriate treatment essential order diminish distress patient health care provider prevention pressure sore accomplished frequent position change patient skin care appropriate nutrition care frequent position change known important effective method prevent pressure sore skin care achieved choosing proper dressing material management exu date protection tissue around wound addition appropriate nutrition care order correct protein calorie imbalance also performed necrotic tissue cause inflammation also good source bacterial growth therefore debridement necrotic tissue fundamental essential part treatment pressure sore meanwhile patient candidate surgical treatment due poor general condition many methods dressing performed recently dressing material silver component vacuum assisted closure dressing performed frequently case surgical treatment debridement necrotic tissue reconstruction performed split thickness skin grafting full thickness skin grafting primary closure however majority reconstruction performed flap surgery rotation advancement flap usually performed
frequently asked question regarding types geosynthetics long last paper answers question exposed geotextiles geomembranes assuming properly designed installed furthermore compares new results earlier lifetime prediction results covered geomembrane nonexposed covered lifetime conditions thick high density polyethylene hdpe geomembrane previously evaluated published landfill incubation devices four elevated temperatures degrees used prediction order reach retained strength elongation considering three stages depletion antioxidants induction time iii reduction mechanical properties lifetime extrapolation made degrees reduction value called halflife throughout paper geomembrane conditions approximately years since laboratory incubation times took years nonexposed geosynthetics evaluated supposition covered situation generally moot point geosynthetics customary applications exposed uncovered geosynthetics however situation quite different ultraviolet radiation elevated temperature full oxygen available shortens service lifetime much evaluation situation authors utilized laboratory ultraviolet fluorescent tube weathering devices per astm incubation purposes seven different geotextiles five different geomembranes evaluated material incubated degrees reduction strength elongation occurred data extrapolated degrees laboratory halflife values comparison nonexposed condition ratio nonexposed exposed lifetime hdpe geomembranes approximately seven calculations exposed geosynthetics progressed using site specific radiation obtain equivalent field halflife phoenix arizona conditions illustrated although procedure applicable worldwide halflife predictions geotextiles vary months needle punched nonwovens years monofilaments high antioxidant formulated products results geomembranes vary years hdpe highest exposed halflife results took years laboratory incubation achieve felt interesting presented first time international audience
paper new framework introduced develop coupled active reactive market distribution networks distributed energy resources ders synchronous machine based distributed generations wind turbines offer active reactive powers proposed market considered ders multicomponent reactive power bidding structures introduced based capability curves also hourly speed variations wind turbines considered proposed model distribution company buys active reactive powers wholesale market sells via market demand side active responsive loads aggregators participate market using demand bidding buyback program objective function proposed market minimize active reactive power costs ders distribution companies penalty cost emission cost running demand bidding buyback program effectiveness proposed method examined bus radial distribution test system
aim study aim evaluate progression free survival pfs overall survival patients metastatic clear cell renal cell carcinoma sunitinib everolimus treatment patients methods years enrollment years follow consecutively presenting patients men women treated results total patients died patients survived median pfs treated patients months months median pfs months median months patients treated everolimus conclusion development induced hypothyroidism hypertension neutropenia edema significant predictive prognostic factor
developing imaging laser sensors several years acquire additional information scene range data enhances potential detect unwanted people objects sensors utilized applications safety control security surveillance forth paper focus two types sensors high frame rate type compact type realize high frame rate type system developed two key devices linear array receiver single inalas apd detectors read roic array fabricated sige bicmos process connected electrically roic measures intensity also distance scene high speed analog signal processing addition scanning mirror mechanically perpendicular direction linear image receiver realized high speed operation frame rate number pixels compact type imaging laser sensor development succeeded downsizing transmitter scanning laser beam two dimensional mems scanner obtain wide field view image well angle mems scanner receiving optical system large area receiver needed developed large detecting area receiver consists rectangular detectors output signals detector summed phase original circuit evaluates signal level removes low level signals sums order improve signal noise ratio following paper describe system configurations recent experimental results two types imaging laser sensors
introduction previous studies demonstrated high prevalence cigarette smoking patients presenting emergency department acute asthma despite clinical public health importance recent multicenter efforts characterize patient population aimed update prevalence cigarette smoking among patients asthma exacerbations methods multicenter chart review study eds across states identified patients aged years asthma exacerbations classified patients three groups based smoking status never smoker former smoker current smoker fit multivariable logistic regression models examine independent predictors current smoker results enrolled patients never smokers accounted former smokers current smokers multivariable model demonstrated several independent predictors current smoking older age age years non hispanic white black public insurance asthma specialist conclusion large multicenter study patients asthma exacerbations demonstrated one three patients current smokers burden current smokers changed multicenter findings late persistently high burden suggests inadequacy current measures manage tobacco use high risk patients elsevier ltd rights reserved
objective study obtain design value calculated according limit states design method utilization chinese fir building structure field green building material total specimens tested static compression method normal lognormal distributions selected fit experimental data results indicated reliability index increased nonlinearly live dead ratio resistance partial coefficient increased meet target index beta suggested design values compressive strength chinese fir set mpa grade respectively
superior broadband performance iir frequency planar beam filters relative conventional fir true time delay beamforming recently reported using computational electromagnetics real time emulations antenna test range resulting significant improvements bit error rates bers presence broadband interference massively parallel systolic vlsi circuit polyphase architectures also reported madanayake int circuit theory appl case direct form signal flow graph sfg architecture operating maximum throughput antenna frames per clock cycle mfpcc superior broadband performance iir frequency planar beam filters extended direct form signal flow graph sfg architecture madanayake int circuit theory appl novel differential form sfg architecture order reduce overall complexity proposed method employs differential form polyphase iir frequency planar beam sfg corresponding circuit architecture implement required input output space time difference equation resultant digital hardware significant advantage much reduced multiplier complexity relative direct form structure example look ahead pipelining employed polyphase architectures two three four phases corresponding reductions multiplier complexity respectively proof concept prototype circuit designed implemented xilinx fpga device two phase case operating frame rate million linear frames per second uniform linear array ula corresponding frames per clock cycle circuit clock frequency mhz circuit optimized low critical path delays cpds using look ahead pipelining order three ultra wideband uwb radio frequency implementations fields radio astronomy radar wireless communications custom vlsi versions proposed circuits required
work aimed improve teaching effect practice link water pollution control engineering hereinafter described reform activated carbon adsorption experiment one hand changed traditional data analysis method cod adsorption experiment according practice experience hand added new comprehensive decoloration experiment effects dosage dye kind kind temperature discussed via practice reform proved successful increasing students ability applying theory practice well research interest
give fully dynamic data structure maintaining approximation hausdorff distance two point sets constant dimension standard problem computational geometry solution approximation factor epsilon constant epsilon expected update time logu loglogn universe size number points result paper greatly improves previous exact method required polylogn time worked semi online setting model computation word ram model elsevier rights reserved
order minimize environmental problems caused pollution public private third sector organizations began adopting environmental marketing strategies tool meet growing demand concerned stakeholders environmental crisis among many organizations cause negative environmental impacts regulated environmental agencies stand gas stations thus study aimed characterize environmental marketing actions taken municipal gas station sao gabriel several interviews conducted managers city gas stations found relation environmental issues employees aware environmental problems gas stations reusing water made used car washes rainwater harvesting posts suitable place storage materials waste stored covered places packaging made resistant sealed containers stations contingency plans minimize leakage fuel offering trained staff case situations like explosions accidents normal operations products leak many differences perceptions managers relation environmental issues however results revealed sao gabriel municipality gas stations work within standards set legislation since adopt measures required inspectors environmental context
paper propose innovative quantum private comparison qpc protocol based partial bell state measurement view linear optics enabling two parties compare equality private information help semi honest third party partial bell state measurement realized using linear optical elements experimental measurement device independent quantum key distribution mdi qkd schemes makes believe protocol realized near future security analysis shows participants leak private information
aim study investigate risk factors sensitization preservatives examine extent different preservatives registered chemical products occupational use denmark retrospective epidemiological observational analysis data university hospital conducted patients occupational contact dermatitis consecutively patch tested preservatives european baseline series extended patch test series year period information regarding preservatives chemical products occupational use substances materials registered danish product register database probas obtained frequency preservative contact allergy patients occupational contact dermatitis patients preservative contact allergy significantly frequently facial dermatitis versus age years versus patients without preservative contact allergy whereas atopic dermatitis less frequently observed versus preservative contact allergy frequent painters occupational contact dermatitis compared non painters occupational contact dermatitis mainly caused contact allergy methylisothiazolinone contact allergy formaldehyde analysis registered substances materials probas revealed preservatives occurred several product categories paints varnishes cleaning agents cooling agents polishing agents formaldehyde isothiazolinones extensively registered probas extensive use formaldehyde isothiazolinones chemical products occupational use may problematic worker appropriate legislation substitution employee education prioritized
relationships parents friends important contexts developing romantic relationship skills parents friends may influence timing involvement quality romantic relationships three models joint influence parents friends direct effects model mediation model moderator model proposed present study uses data longitudinal study female caucasian examine attachment friendship quality age years predict romantic relationship involvement quality ages years results supported direct effects model attachment friendship quality uniquely predicting different romantic relationship outcomes findings provide support important influence family friends early romantic relationships
paper presents numerical approximation technique boltzmann equation based moment system approximation velocity dependence discontinuous galerkin finite element approximation position dependence closure relation moment systems derives minimization suitable divergence divergence based closure yields hierarchy tractable symmetric hyperbolic moment systems retain fundamental structural properties boltzmann equation approximation position dependence based discontinuous galerkin finite element method resulting combined discontinuous galerkin moment method corresponds galerkin approximation boltzmann equation renormalized form new moment closure formulation engenders new upwind numerical flux function based half space integrals approximate distribution establish proposed upwind flux ensures entropy dissipation discontinuous galerkin finite element approximation numerical results presented one dimensional test case elsevier ltd rights reserved
current spaceborne synthetic aperture radar systems operated illuminate scene along satellite flying direction however many cases interested areas parallel flying direction innovative smart imaging mode acquired employed illuminating scene along given direction novel three axis attitude steering method proposed smart imaging mode first mathematical model attitude steering built considering restrictive conditions zero doppler centroid requirement position interested area iterative optimisation algorithm designed calculate three axis steering angles finally experiment results using satellite tool kit tool validate proposed methods well especially case coastline imaging
paper presents results long term continuous hydrologic simulation analysis watershed scale residential rainwater harvesting rwh program chollas creek watershed san diego california usa environmental protection agency storm water management model swmm simulated rainfall runoff responses variations rwh network including rwh unit storage size number implementing households amount time unit allowed release captured runoff drain delay time takes unit drain coefficient discharge comparison results found reductions increase linearly capacity implementation maximum long term watershed volumetric reductions observed period analysis range rwh storage sizes barrels cisterns ratio overflow underdrain flow ranging exhibits ability cisterns fully capture majority annual long term events sensitivity analysis found regional precipitation characteristics disconnection rooftop runoff impact long term watershed reduction potential available rwh capacity drain delay control dry duration time increased reduction variability cisterns though long term reductions significantly impacted normalization net present value npv volumetric reductions yielded rwh unit cost per watershed runoff reduced average per year minor variations cost based extent watershed implementation highlights potential incrementally institute rwh programs case study location rain barrel provided greatest cost effectiveness reducing average runoff per dollar invested analysis period elsevier rights reserved
identification potential child maltreatment using reliable valid screening instruments particular importance high risk populations current study investigates psychometric properties brief child abuse potential bcap inventory mothers enrolled opioid substitution therapy bcap risk abuse scale strong internal reliability comparisons valid invalid protocols lie scale random responding failed find systematic differences across variables although faking good profile significantly lower scores psychological well six factor solution obtained conceptually strong subsequent analyses suggested rigidity may independent subscale needs investigation results add evidence potential utility bcap measure child abuse potential replication studies needed ascertain whether subscales derived convergent predictive utility
people develop false memories committing aggressive acts process compare developing false memories victimhood current research used simple false feedback procedure implant false memories committing aggressive acts causing black eye spreading malicious gossip victimhood receiving black eye compared false memories subjects true memories equivalent events false aggressive memories easy implant particularly minds individuals proclivity towards aggression implanted false memories indistinguishable true memories events several dimensions including emotional content implications aggression related memory generally well false confessions discussed elsevier rights reserved
investigate extent people earlier circumstances experiences shape subsequent life courses using longitudinal data provide dynamic analysis employment caregiving histories people years analyse histories sequences using optimal matching cluster analysis identify five distinct employment caregiving pathways regression analysis shows prior embarking pathways people already differentiated life stage gender attitudes towards family gender roles difference differences estimation shows initial differences income subjective health wellbeing widen time others narrow particular following caregiving intensive pathways end poorer also experience relative decline subjective health wellbeing results confirm earlier circumstances exert strong influence later life courses consistent pre determination persistence path dependence elsevier ltd rights reserved
pulse train repetition ratio pulse range dominant factors achieve high treatment high energy density achieving precise control according purpose treatment diagnosis important method controlling action time changing pulse train repetition range used mainly output pulse transcranial magnetic stimulation bits microprocessor grafted achieve safe control circuit operation transcranial magnetic stimulation operated power device control section research carried motion output characteristics transcranial magnetic stimulation according current pulse waveform pulse train stimulation coil result transcranial magnetic stimulation output efficiency reduced transcranial magnetic stimulation output showed regular increase according increase pulse train repetition rate pulse repetition rate increased condenser charged voltage study introduces treatment pulse using transcranial magnetic stimulation changing various bacteria caused rat head one obtain good changing characteristics various bacteria adjusting charging voltage treatment pulse forming magnetic field inducing time
pier scour caused bridge failures catastrophic consequences aim study develop verify mathematical model pier scour predictions new approach taken combines shallow water equations non hydrostatic pressure corrections non uniform mesh horizontal terrain following layers vertical approach significantly improves computational efficiency conventional computational fluid dynamics approach concluded emerging lateral sides pier cylinder scour deepens patterns migrate upstream towards pier upstream nose upstream side scour continues grow bed slope reaches angle repose sediments downstream side scour grows equilibrium reached scour hole shallower downstream upstream pier presence pier causes strong downflow near upstream nose strong vortex foot upstream side weak vortex downstream side predicted flow velocity scour depth agree well measurements terrain following layer feature particularly useful scour computations high efficiency makes model practical field scale applications highly relevant improved design pier foundations pier scour control
single report examined risk factors predict future onset type eating disorder core symptom dimensions crosscut disorders addressed aims advance knowledge regarding risk factor specificity data prevention trials targeted young women body dissatisfaction age collected annual diagnostic interview data year follow combined identify predictors subthreshold threshold anorexia nervosa bulimia nervosa binge eating disorder bed purging disorder negative affect functional impairment predicted onset eating disorders thin ideal internalization body dissatisfaction dieting overeating mental health care predicted onset subthreshold threshold bed positive thinness expectations denial cost pursuing thin ideal fasting predicted onset disorders similar risk factors predicted core eating disorder symptom onset low bmi dieting specifically predicted onset subthreshold threshold low bmi subset factors showed unique predictive effects multivariate models likely due moderate correlations risk factors results provide support theory pursuit thin ideal resulting body dissatisfaction dieting unhealthy weight control behaviors increase risk binge purge spectrum eating disorders suggest youth inherently lean rather purposely pursuing thin ideal risk impaired interpersonal functioning negative affect transdiagnostic risk factors suggesting factors targeted prevention programs general scientific summary findings suggest pursuit thin beauty ideal resulting body dissatisfaction weight control behaviors increase risk developing eating disorders involving binge eating unhealthy weight control behaviors inherently lean young women rather purposely pursuing thin ideal risk eating disorders involving dangerously low body weight findings also suggest negative affect impaired interpersonal functioning transdiagnostic factors increase risk full spectrum eating disorders
conventional normalized subband adaptive filter nsaf using constant step size generally faces inherent trade steady state misalignment convergence rate propose herein variable step size nsaf algorithm minimizing mean square deviation msd optimal weight vector weight vector estimate utilization shrinkage denoising technique estimation error involved step size adaptation subband individually proposed algorithm capable tracking non stationary environments without explicit whitening assumption input signal subband proposed algorithm exhibits low steady state msd even input signal subband colored simulation results validate low misalignment good tracking ability proposed algorithm system identification application elsevier rights reserved
data aggregation recognized key method reducing amount network traffic energy consumption wireless sensor network nodes mobile agent technology represents distributed computing paradigm proposed means increasing energy efficiency data aggregation tasks addressing scalability problems centralized methods nevertheless itineraries followed travelling mas largely determine overall performance data aggregation applications along line article introduces novel algorithmic approach energy efficient itinerary planning mas engaged data aggregation tasks algorithm adopts iterated local search approach deriving hop sequence multiple travelling mas deployed source nodes simulation results demonstrate performance gain method existing multiple itinerary planning methods
paper applied expansion method class volterra integral differential equations viscoelastic fluid solution procedure method help symbolic computation matlab utter simplicity obtained results show expansion method effective
current study tested interactive main effects two key aspects perfectionism personal standards evaluative concerns emotional intelligence based model perfectionism gaudreau data collected online undergraduates moderated regression analyses revealed personal standards positively associated aspects whereas concern mistakes negatively associated aspects except utilization emotions problem solving ueps interactions personal standards evaluative concerns significant according gaudreau recommendations differentiated four perfectionism subtypes pure personal standards perfectionism psp non perfectionism mixed perfectionism pure evaluative concems perfectionism ecp calculated predicted scores aspects results supported four hypotheses model perfectionism gaudreau emotion self regulation ers appraisal emotions others aeo appraisal self emotions aes partially supported model utilization emotions problem solving ueps results interpreted light perfectionism social disconnection model hewitt colleagues hewitt flett sherry caelian elsevier ltd rights reserved
objective study used aim reach effectiveness adoption implementation maintenance framework evaluate promotora led community health program designed latinas ages older sought improve physical activity nutrition stress management method mixed methods evaluation approach administered participant organizational levels focus efficacy adoption implementation maintenance components aim theoretical model results program shown effective improving participants eating behaviors increasing physical activity levels lowering depressive symptoms promotoras felt motivated sufficiently prepared deliver program implementation challenges reported child care opportunities increased focus mental well suggested discussion promotora delivery model promise program sustainability promotoras participants alike expressing interest leading future programs
study critical information maximum current voltage estimation used components mean values semiconductor parts assessment expected power losses half bridge bidirectional buck boost converter equipped filter carried practical model converter derived transfer function duty cycle voltages input output calculated via linearization method signal flow graph converter obtained decrease power losses concept zero voltage switching used explained
recent demands reduce pollutant emissions improve energy efficiency driven implementation hybrid solutions mobile machinery paper presents results numerical experimental analysis conducted hydraulic hybrid excavator hhe machinery study middle size excavator whose standard version modified introduction energy recovery system ers proposed ers layout designed recover potential energy boom using hydraulic accumulator storage device recovered energy utilized pilot pump machinery operates motor thus reducing torque required internal combustion engine ice analysis reported paper validates hhe model comparing numerical experimental data terms hydraulic mechanical variables fuel consumption mathematical model shows capability reproduce realistic operating conditions realized prototype tested field detailed energy analysis comparison standard hybrid excavator models carried evaluate energy flows along system showing advantages weaknesses possibilities improve machinery efficiency finally fuel consumption estimated model measured experiments presented highlight fuel saving percentages hhe model important starting point development energy saving solutions
development printable biomaterial inks critical application printing biomedicine print high resolution structures fidelity computer aided design materials used printing must capable deposited surface maintaining printed structure dual cross linking hyaluronic acid system studied printable hydrogel ink encompassed shear thinning self healing behaviors via guest host bonding well covalent cross linking stabilization using photopolymerization either guest host assembly covalent cross linking used alone long term stable structures formed network relaxation printing dispersion ink filaments prior stabilization respectively dual cross linking hydrogel filaments formed structures greater layers stable month loss mechanical properties printed filament size ranged depending printing parameters needle size speed extrusion flux printed structures functionalized rgd peptide support cell adhesion work highlights importance ink formulation cross linking printing stable hydrogel structures
atm small molecule inhibitor cyclin dependent kinases vitro activity lymphoid malignancies two concurrent phase trials evaluated atm relapsed refractory chronic lymphocytic leukemia cll mantle cell lymphoma mcl using recommended phase dosing twice weekly every weeks primary objective objective response rate orr nineteen patients accrued cll mcl four cll patients achieved stable disease two mcl patients achieved partial response one additional mcl patient subsequently achieved months completion atm tumor lysis syndrome reported conclusion atm safely administered patients relapsed refractory cll mcl cll patients tumor reductions orr low mcl activity noted orr
whether video game play affects social behavior topic debate many argue aggression helping affected video game play whereas stance disputed others present research provides meta analytical test idea depending content video games affect social outcomes data independent studies participants revealed violent video games prosocial video games significant association social outcomes whereas violent video games increase aggression aggression related variables decrease prosocial outcomes prosocial video games opposite effects effects reliable across experimental correlational longitudinal studies indicating video game exposure causally affects social outcomes short long term effects
central aortic blood pressure arterial stiffness sympathetic nerve activity increase age women however unknown age related increase sympathetic activity influences aortic hemodynamics carotid femoral pulse wave velocity cfpwv index central aortic stiffness goal study determine aortic hemodynamics cfpwv directly influenced sympathetic nerve activity measuring aortic hemodynamics cfpwv muscle sympathetic nerve activity msna women autonomic ganglionic blockade trimethaphan camsylate studied young premenopausal older postmenopausal women women differ body mass index mean arterial pressure baseline postmenopausal women higher aortic pulse pressure augmented pressure augmentation index adjusted heart rate beats min wasted left ventricular pressure energy cfpwv young women ganglionic blockade postmenopausal women greater decrease variables comparison young women additionally baseline msna negatively correlated reductions aortic pulse pressure augmented pressure wasted left ventricular pressure energy ganglionic blockade postmenopausal women results suggest aortic hemodynamic parameters influenced sympathetic activity greater extent older postmenopausal women young premenopausal women new noteworthy autonomic ganglionic blockade results significant decreases multiple aortic pulse wave characteristics augmented pressure central pulse wave velocity older postmenopausal women young premenopausal women certain aortic pulse wave parameters negatively influenced sympathetic activity greater extent older postmenopausal women
necessary design system automatic flat wheel brake control control object deformable wheel moves three modes rolling sliding locking purpose control system stop wheel achieve goal specified quality connect braking system pid controller develop control models via matlab simulation software used visualize analyze data using simulink files authors published elsevier
physics combusting flows consists complex interaction chemical reactions fluid mechanics radiation temperature one important parameters processes laser based imaging techniques frequently used assess temperature information reactive systems without perturbing system study verify feasibility temperature measurement tunable absorption spectroscopy technology methane air premix flat flame selected target test combustion stability kind flame temperature measurement distribution radical premix flat flame different operating conditions obtained using planar laser induced fluorescence plif low equivalence ratio radicals distribute uniformly flame adequate oxygen premix gas condition uniform distribution flame selected tunable absorption spectroscopy measurement selection absorption lines measurement spectrum band simulated lifbase considering slope sensitivity snr test transitions suitable temperature measurement flame dye laser pumped frequency doubled yag laser used generated laser dye laser operated mixed dye dcm high conversion efficiency investigate transitions laser tuned similar similar separately step pulses recorded step laser pulses reflected beam splitter collected detector pulses passed flame collected detector signal two detectors recorded oscilloscope acquired computer automatically line shape transitions obtained fitting experimental data voigt function integral ratio fitting results two lines calculated temperature flame could deduced integral ratio temperatures different positions surface burner varied heights flame center obtained measuring integrated absorption ratio two transitions test results method compared report reference temperature burner structure measured ways results two tests agree well shows method potential calibration two dimension thermometry flame two line plif
letter propose change detection method based gabor wavelet features high resolution vhr remote sensing images first gabor wavelet features extracted two temporal vhr images obtain spatial contextual information gabor waveletbased difference measure gwdm designed generate difference image gwdm new local similarity measure defined markov random field neighborhood system incorporated obtain local relationship coefficient variation method applied discriminate contributions different features finally fuzzy means cluster algorithm employed obtain final change map experiments employing quickbird spot images demonstrate effectiveness proposed approach
problem addressed paper achieve robust motion control inertia wheel pendulum iwp specifically trajectory tracking control pendulum iwp assumption uncertain model discussed two new robust algorithms introduced whose design departs model based input output linearization controller control problem firstly solved means adaptive neural network based controller secondly adaptive regressor based controller controllers rigorous analysis respective closed loop system given barbalat lemma used conclude asymptotic convergence pendulum tracking error addition wheel velocity adaptive extension signals shown bounded extensive real time experimental study validates introduced theory performance classical linear pid controller two new adaptive schemes compared
approximately year sedimentary record metal elements sediment core collected huaihe river huainan city anhui province china reconstructed using geochronology copper evaluated enrichment factor indicated minor contamination due water pollution accidents huaihe river occurred lead presented severe pollution among metals studied especially use leaded petrol atmospheric deposition coal combustion flue gases could contributed contamination spite general good quality mean sediment pollution index spi sediment core evaluated spi based principal component analysis worse sediment qualities upper section still observed suggesting intensive human activities causing increasing concentrations metals recent decades
examined associations enrollment medicare part pharmacy benefits changes medication acquisition department veterans affairs pharmacies included women random sample men enrollees years old january alive december used difference differences models propensity score weighting examine changes medication acquisition part implemented part implementation veterans part enrolled veterans meeting inclusion criteria enrolled day medication supplies decreased enrolled veterans increased nonenrolled veterans difference differences reductions day supplies greater among veterans required pay copayments medications used medicare outpatient services
describe design trial run integrated course instruction reading writing computer programming order assess potential synergies learning together twelve pre teen students diagnosed dyslexia took sequence lessons approximately minutes month period addition computer learning activities handwriting word reading word spelling sentence text reading comprehension coding activities using kokopelli world blocks style visual language microworld results suggest potential synergies form integrated instruction written language computer programming include increased student motivation complementary pedagogical affordances increased awareness relationship written language technology
electrochemical impedance spectroscopy eis used monitoring enzymatic pineapple waste hydrolysis process system employed consists device called advanced voltammetry impedance spectroscopy potentiometry analyzer avispa equipped specific software application stainless steel double needle electrode eis measurements conducted different saccharification time intervals partial least squares pls used model relationship eis measurements sugar determination hpaec pad hand artificial neural networks multilayer feed forward architecture quick propagation training algorithm logistic type transfer functions gave best results predictive models glucose fructose sucrose total sugars coefficients determination root mean square errors prediction rmsep determined rmsep rmsep artificial neural networks anns respectively therefore combination eis based technique ann models suggested promising alternative traditional laboratory techniques monitoring pineapple waste saccharification step
duke severity illness checklist dusoi evaluated primary care adult patients using data collected medical providers time patient visit later chart auditor severity scores individual diagnoses determined summing ratings four non disease specific parameters symptom level complications prognosis without treatment expected response treatment mean diagnosis severity scores scale among prevalent diagnoses varied low menopausal syndrome high sprains strains overall severity score calculated combining diagnosis severity scores giving highest weights severe diagnoses provider generated overall severity scores mean auditor generated overall severity scores mean significantly correlated coefficient agreement diagnoses varied individual contribution overall severity score lipid disorder sprains strains separate comorbidity severity scores calculated measure severity patient health problems except diagnosis study example patients menopausal syndrome existing health problems generated high mean comorbidity severity score patients sprains strains low mean comorbidity score dusoi checklist used clinical setting providers auditors produce quantitative severity scores diagnosis overall comorbidity based entirely upon clinical judgment method useful controlling severity illness clinical studies indicating outcome medical care terms reduction severity illness following medical interventions
rna sequencing use high throughput next generation sequencing technology survey characterize quantify transcriptome genome rna sequencing used analyze pathogenesis several malignancies melanoma lung cancer colorectal cancer rna sequencing identify differential expression genes deg mutated genes fusion genes gene isoforms disease states rna sequencing used investigation several colorectal diseases colorectal cancer inflammatory bowel disease ulcerative colitis crohn disease irritable bowel syndrome
estrogen receptor progesterone receptor human epidermal growth factor receptor lacking triple negative breast cancers tnbc leading cause death successful transport chemotherapeutics tnbc receptor mediated targeting image guided treatment serious challenge cancer therapy work folic acid encapsulated nanoscale metal organic framework nmofs developed surface upconversion nanoparticles ucnps targeted responsive anticancer drug carrier construct assembled core shell drug delivery system dds nayf taken ucnps outstanding luminescence properties folic acid encapsulated nmofs based tetravalent metal directly developed ucnps labeled ucnp uio excitingly ucnp nontoxic towards tnbc cells mda normal cell lines niht anticancer drug doxorubicin dox encapsulated ucnp uio high drug loading efficiency dox per nmofs shows responsive drug release dox loaded ucnp successfully enters mda cells folate receptor mediated endocytosis exhibits higher cytotoxicity normal cells flow cytometry nuclear apoptosis studies suggest present dds potential applicable breast cancer therapy reduce side effects elsevier rights reserved
facial hair strongly influences people judgments men sodo sexual attributes however nature judgments often contradictory levels intermediate facial hair growth presented raters stage female raters menstrual cycles might influenced past findings quantified men women judgments attractiveness health masculinity parenting abilities photographs men clean shaven lightly heavily stubbled fully bearded also tested effect menstrual cycle hormonal contraceptive use women ratings women judged faces heavy stubble attractive heavy beards light stubble clean shaven faces similarly less attractive contrast men rated full beards heavy stubble attractive followed closely clean shaven light stubble least attractive men women rated full beards highest parenting ability healthiness masculinity ratings increased linearly facial hair increased effect pronounced women fertile phase menstrual cycle although attractiveness ratings differ according fertility findings confirm beardedness affects judgments male socio sexual attributes suggest intermediate level beardedness attractive full bearded men may perceived better fathers could protect invest offspring elsevier inc rights reserved
brain derived neurotrophic factor bdnf plays important role activity dependent synaptic plasticity altered blood bdnf levels frequently identified people autism spectrum disorders asd however wide discrepancies evidence therefore performed present systematic review meta analysis aimed qualitative quantitative synthesis studies measured blood bdnf levels asd control subjects observational studies identified electronic database searching also hand searching reference lists relevant articles total papers initially identified review eventually twenty studies included meta analysis meta analysis blood bdnf patients asd control subjects demonstrated significantly higher bdnf levels asd compared controls smd addition subgroup meta analyses performed based bdnf specimen present meta analysis study led conclusion bdnf might play role autism initiation propagation therefore considered possible biomarker asd
effective separation electron hole pairs plays key role enhancing photo catalytic performance semiconductors density electrons participating reduction reaction also determines photocatalytic performance report rational design photocatalyst assembly composed type semiconducting two dimensional nanosheets carbon nanotubes cnts plasmonic nanocubes exhibits enhanced density electrons controlled unidirectional change flow promote photocatalytic hydrogen evolution reaction plasmonic nanocubes inject hot electrons conduction band increase density electrons cnts act power pump electrons steer electron flow conduction band reactants photocatalytic performance agid cnts assembly dramatically enhanced evolution water enhanced photocatalytic activity due efficient unidirectional transfer electrons high density efficient separation pairs elsevier rights reserved
clouds play pivotal role surface energy budget polar regions use two largely independent data sets cloud surface downwelling radiation observations derived satellite remote sensing evaluate simulated clouds radiation polar ice sheets oceans state art atmospheric reanalyses era interim modern era retrospective analysis research applications coupled model intercomparison project phase cmip climate model ensemble first show compared clouds earth radiant energy system energy balanced filled cloudsat calipso better represents cloud liquid ice water path high latitudes owing recent explicit determination cloud phase part new release reanalyses climate models disagree widely amount cloud liquid ice polar regions compared observations find significant inconsistent biases model simulations cloud liquid ice water well downwelling radiation components cmip models display wide range cloud characteristics polar regions especially regard cloud liquid water limiting representativeness multimodel mean cmip models cnrm giss gfdl ipsl cmb clearly outperform others enhances credibility projected future cloud radiation changes high latitudes given rapid changes polar regions global feedbacks involved future climate model developments target improved representation polar clouds end remote sensing observations crucial spite large remaining observational uncertainties evidenced substantial differences two data sets
proposed smart single viewing axis optical laser line illumination based shape sensor uses electronically controlled variable focus lens ecvfl optical beamforming specifically novel sensor design deploys laser line illumination scanning camera based spatial image processing target illuminated laser line spot leads faster shape reconstruction versus previously demonstrated point scanned ecvfl based shape sensor proposed sensor experimentally demonstrated using liquid ecvfl transverse direction motion mechanics successfully map depth steep surface profile objects mean measurement error line illumination sensor demonstrates times shorter mapping time per scanned point compared point scan based sensor proposed shape sensor suitable scenarios high transverse resolution inspections required objects holes crevices complex external structures
paper deals use robotic operating system ros educational tool control engineering students software suite fact simplifies required counnunication effort distributed systems networks helping development learning tools robotic control fields particular present tool allows user understand tuning behaviour proportional integral derivative pid controllers used control first order plus dead systems distributed networks ifac international federation automatic control hosting elsevier ltd rights reserved
many control engineering problems desired analyze systems particular frequency intervals interest paper focuses development frequency interval cross gramians linear bilinear systems new generalized sylvester equations calculating frequency interval cross gramians derived order used obtain information regarding controllability observability within single matrix advantage proposed method computationally efficient compared existing gramian based techniques since half number equations need solved order obtain information regarding controllability observability system compared existing techniques numerical examples provided demonstrate computational efficiency proposed method uses frequency interval cross gramians relative existing methods
monitoring human hydration level bhl key factor preventing urinary system disorders paper proposes smart holistic system comprises two components urine colour measurement system installed restrooms mobile app used interact measurement unit track user bhl view statistical data advice main prototype built based low cost embedded internet devices coupled rgb sensors light sources based rgb theory system tested laboratory using liquid mixed food colour different shades results presented mobile app system successfully implemented ubiquitous self test solution raising awareness greener user friendly way
objective hypertension htn obesity low cardiorespiratory fitness crf associated increased risk cardiovascular event enrolling overweight obese individuals htn current study aimed estimate cardiovascular risk cvr vascular age profiles analyzing potential sex differences determine whether higher chronological age whether cvr associated low level crf methods overweight obese non hispanic white participants men women primary htn cvr determined using new pooled cohort risk equations framingham method respectively considering values peak oxygen uptake participants divided tertiles sex results cvr higher men compared women irrespective age irrespective sex higher chronological age age bmi higher low crf group compared groups differences cvr values separated crf groups conclusion pooled cohort equations could underestimate risk suffering cardiovascular event following years overweight obese non hispanic white women htn compared men appears useful tool communicating cvr population irrespective sex crf alone may enough moderate cvr copyright wolters kluwer health inc rights reserved
schiff bases thiosemicarbazones family variable substituents known show enhanced growth inhibitory properties view facts part continuous interest cationic schiff bases developed several schiff base ligands formyl hydroxyphenyl methyltriphenylphosphonium present study compounds characterized various spectroscopic methods infrared spectra nmr nmr hresims ray crystallography three substituents namely tsc tsc tsc exerted strong growth inhibitory properties inhibiting highly metastasis prostate cancer growth thiosemicarbazone ethyl phenyl moiety displayed potent activity cell lines tested mit data obtained analysis establishes phenyl substituent enhances growth inhibitory properties compound result affirms tsc would serve lead scaffold rational anticancer agent development elsevier rights reserved
objective assess diagnostic status sociodemographic health profiles students special educational needs sen public educational system map use educational social services methods sample comprised sen students total students results students established diagnosis prevalent sen condition intellectual disability low percentage use specialized educational services support found neurodevelopmental disorders prevalence data suggest reporting school system conclusion results suggest mismatch diagnostic reports sen condition legally recognized according brazilian law addition reporting specialized service use students disabilities
pathomechanism cluster headache entirely understood central peripheral components suggested recent report showed transcranial magnetic stimulation measured cortical excitability increased hemisphere ipsilalteral pain current study set investigate amplitude resting brain fmri activity find signatures increased excitability high resolution weighted resting state functional mri images acquired seventeen patients pain free period twenty six healthy volunteers patients data normalized inverted along midsagittal axis according headache side independent component analysis modified dual regression approach used reveal differences resting state networks furthermore timecourses decomposed five frequency bands discrete wavelet decomposition also regressed original data reveal frequency specific resting activity maps two identified resting state networks showed alterations data inverted patients headaches left ipsilateral attention network showed increased connectivity frequency band group dataset cerebellar network showed higher functional connectivity range ipsilateral cerebellum data patients headache left inverted right similar increased signal found ipsilateral attention network band cerebellar network showed increased connectivity cerebellum band patients fourier analysis area revealed increased power cases results showed alterations brain functional networks alterations resting state activity found hemisphere ipsilateral pain signifying altered cortical processing pathomechanism
despite proposed benefits applying shared distributed leadership models healthcare studies explored leadership beliefs clinicians ascertained whether differences exist professions current article aims address gaps additionally examine whether clinicians leadership beliefs associated strength professional team identifications online survey responded healthcare workers community interprofessional teams mental health settings across east england differences emerged professional groups leadership beliefs professions reported high level agreement shared leadership positive association emerged professional identification shared leadership participants expressed strongest level profession identification also reported greatest agreement shared leadership association demonstrated team identification shared leadership findings highlight important link group identification leadership beliefs suggesting strategies promote strong professional team identifications interprofessional teams likely conducive clinicians supporting principles shared leadership future research needed strengthen link examine leadership practices healthcare workers
portable devices today used areas life thanks ease use well applications unique features increase number users however also leads increase security threats study examines threats mobile operating systems addressing four mobile operating systems android apple ios symbian java highest number users study provides statistical information features corresponding operating systems areas use study important threats faced mobile operating systems malware vulnerabilities attacks risks posed threats analyzed chronological order future oriented security perspective suggested
fluidic artificial muscles popular robotics function biomimetic actuators pneumatic version widely investigated novel water hydraulic artificial muscle wham high strength developed study whams applied underwater manipulators widely used ocean development environment friendly characteristics high force weight ratio good bio imitability therefore strength whams improved fit requirements underwater environments work pressure water hydraulic components however understanding mechanical behaviors whams necessary whams use work media pressure control different used pneumatic artificial muscles paper presents static dynamic characteristics wham system including water hydraulic pressure control circuit test system designed built analyze drive characteristics developed wham theoretical relationships among amount contraction pressure output drawing force wham tested verified linearized transfer function proposed dynamic characteristics wham investigated simulation inertia load experiments simulation results agree experimental results show proposed model applied control wham actuators
existing studies found restaurant servers sometimes deliver service informed customers race however know considerably less causes underlying discriminatory behaviors within restaurant context study advance literature analyzing data derived survey restaurant servers assess effects working racialized workplace environment characterized racist stereotypical discourse servers reports providing race based service findings reveal strong statistically significant positive relationship observing racialized workplace discourse servers self professed discriminatory behaviors furthermore find effects mediated moderated servers willingness participate discursive spreading racial stereotypes discussing customers race peers conclude identifying suggestions restaurant leaders might consider reduce racial discrimination within restaurant industry
energy conservation emission reduction issues construction phase buildings increasingly important meet challenges sustainable building technological advancement considered one essential driving forces green sustainable construction effective expected anticipated energy conservation efficiency improvement would partially even totally offset energy rebound effect exists paper fills research gap quantitatively investigating impacts technological advancement energy consumption china building construction industry incorporating direct rebound effect first technological advancement rate terms energy efficiency measured constructing energy environmental non radial directional distance function enndf provides strong support porter hypothesis second incorporating asymmetric energy price decomposition framework translog cost function estimated energy savings energy efficiency improvement china construction industry offset due rebound effect based measured results technological advancement rate rebound effect counterfactual analyses find technological advancement contributes million tons standard coal equivalent mtce energy conservation construction industry period mtce energy would saved sector rebound effect empirical findings paper reveal technological innovation well energy pricing reforms tax policies environmental regulations implemented achieve effective energy conservation green building construction elsevier rights reserved
despite great deal feminist work highlighted social construction menstruation seems self evidently natural bodily process yet menstruation defined counts menstruation rarely questioned examining menstruation alongside technologies alter highlights definitional questions article examine menstrual suppression analysis medical journal articles fda advisory committee transcripts paired websites used market menstrual suppression consumers across contexts clinical research fda regulation advertising new definitions menstruation converged distinction bleeding occurs women taking hormonal birth control case menstrual suppression birth control pills provides opportunity study work redefining biological process understood quintessentially natural deeply significant gendered embodiment well challenge consider social material construction gendered bodies
background little information application impact revised criteria diagnosing dementia mild cognitive impairment mci termed major mild neurocognitive disorders ncds dsm evaluate psychometric algorithm diagnosing dsm ncds community dwelling sample characterize neuropsychological functional profile expert diagnosed dsm ncds relative dsm dementia international working group criteria mci methods population based sample adults aged years assessed algorithmic diagnostic criteria used detailed neuropsychological data medical history longitudinal cognitive performance informant interview meeting criteria least one diagnosis data reviewed neurologist expert diagnosis achieved consensus psychiatrist complex cases results algorithm accurately classified dsm major ncd area curve auc confidence interval dsm dementia auc dsm mild ncd auc mci auc compared expert diagnosis expert diagnosis dementia using dsm criteria overlapped dsm dementia cases resulted increase diagnosis relative dsm additional cases less severe memory language impairment instrumental activities daily living iadl impairments compared cases meeting dsm criteria dementia dsm mild ncd overlapped mci cases resulted increase diagnosis additional cases subtly different neurocognitive profile mci cases including poorer social cognition conclusion dsm ncd criteria operationalized psychometric algorithm population setting expert diagnosis using dsm ncd criteria captured cases dsm dementia mci sample included many additional cases suggesting dsm criteria broader categorization
means miedema formation enthalpy model toop model excess free energy enthalpies formation excess entropies activity values components ternary alloy calculated computer programming experimental results show enthalpies formation excess free energy excess entropies ternary alloy negative whole content range minimum values obtained mol mol center dot respectively activity curves show activity values ternary alloy rapidly decrease decrease molar fraction values small molar fraction decreases means strong interaction stable compounds form ternary alloy system
paper study boussinesq equations fractional laplacian dissipation particular prove global regularity smooth solutions boussinesq equations new range fractional powers laplacian main ingredient proof utilization holder estimates advection fractional diffusion equations well littlewood paley technique
ruxolitinib selective potent inhibitor janus kinase jar jak approved treatment patients intermediate high risk myelofibrosis polycythemia vera inadequate response intolerant hydroxyurea investigate carcinogenic potential ruxolitinib administered oral gavage daily rash mice months doses day sprague dawley crl rats years day ruxolitinib effect survival increase incidence neoplastic findings either species exposure auc similar exceeded associated therapeutic use lymphoid depletion decrease extramedullary hematopoiesis spleen occurred rats attributed pharmacologic activity ruxolitinib rash mice increased inflammation nasal cavity observed dose dependent decreases number spontaneous neoplastic preneoplastic lesions observed rats including mammary tumors females adrenal pheochromocytomas males hepatocellular adenomas carcinomas males hepatic basophilic males females eosinophilic males foci peribiliary fibrosis also decreased clear cell foci liver increased females based results studies ruxolitinib considered carcinogenic elsevier inc rights reserved
diagnostic criteria borderline personality disorder bpd include instability identity interpersonal relationships probed whether instability already present bpd patients thoughts others tested bpd patients healthy controls mind wandering task assesses content variability stimulus independent self generated thoughts multi level modeling revealed bpd patients healthy controls mind wander similar extent bpd patients thoughts colored predominantly negatively importantly although thoughts concerned self others much controls fluctuated strongly degree thoughts concerned others also gave extreme ratings self related thoughts extreme also negative valence increased variability supports current conceptualizations bpd may account instability identity interpersonal relationships elsevier ireland ltd rights reserved
introduction assessment central part student learning student involvement peer assessment leads significant improvement students performance supports students learning promotes development evaluation skills encourages reflection aim aim study assess perceptions formative peer assessment fpa initiative within higher education setting undergraduate radiography students methods qualitative action research conducted students allowed anonymously assess assignments using standardized evaluation sheet trained use participants perceptions assessed focus group discussion results findings showed students experiences peer assessment positive students acknowledged received valuable feedback learned assessing peers students recommended need training suggested using one evaluator conclusion fpa initiative study institution believed succeed students positive experience fpa students learnt self assessment implementation promote reflection critical thinking problem solving skills important traits radiography graduate profile radiography clinical practice professional require modify imaging techniques critique images ensure quality care college radiographers published elsevier ltd rights reserved
paper presents optimization formulation designing residential water networks involving harvested rainwater reclaimed wastewater design problem posed multi objective optimization formulation seeks balance objectives total annualized cost fresh water consumption environmental impact life cycle assessment approach undertaken estimating environmental impact seasonal dependence rainwater considered optimization model design approach applied case study city morelia mexico results show significant economic fresh water consumption environmental benefits obtained result proposed approach elsevier ltd rights reserved
novel two dimensional model presented multiaxial thermal stresses elastic strains creep strains creep energy density interfaces solder joints leadless chip resistor lcr assemblies model applicable plane stress plane strain conditions incorporates global local expansivity mismatches interfacial thermal stresses approximated using elementary strength materials theory arbitrary time dependent thermal loading partial differential equations linearized simple finite difference discretization procedure model mathematically straightforward extended include plastic behavior problems involving external loads variety geometries paper presents comparisons finite element results considers mechanics solder creep accumulation stress relaxation predicted model
team currently global technology leader field carbon carbon ultracapacitors hybrid lithium carbon devices main expertise includes material science electrochemistry process engineering manufacturing engineering electrical system design manufacture ultracapacitor electrodes cells modules team participated number international research projects prototypes ultracapacitors hybrids tested institute transportation studies davis jme inc wayne state university labs test results confirm superlative performance devices developed carbon carbon ultracapacitors demonstrate extremely low inner resistance resulting highest power capability efficiency also reduces cooling requirements improves safety parallel hybrid devices demonstrate substantially higher energy power density competing lic technologies order make ultracapacitor technology even attractive automakers new organic electrolytes developed currently testing ionic liquids temperatures degrees voltages
objective examine relationships healthy unhealthy dietary patterns bmi sex age acculturation among mexican americans design cross sectional participants completed culturally tailored healthy unhealthy eating indices multivariable mixed effect poisson regression models compared food pattern index scores dietary intake specific foods bmi sex age acculturation defined language preference generational status setting participants recruited cameron county hispanic cohort study texas mexico border region subjects mexican american males females aged years results participants primarily female overweight obese preferred spanish language first generation status among first generation participants bilingual participants less likely healthy eating pattern preferred spanish speaking participants rate ratio association also found males preferred english speaking females less likely consume healthy foods preferred spanish speaking females among second generation participants preferred english speaking participants likely report higher unhealthy eating pattern preferred spanish speaking participants higher unhealthy eating patterns also found females preferred english females preferred spanish bilingual younger male participants likely higher unhealthy eating pattern bmi diabetes status significantly associated healthy unhealthy eating patterns conclusions acculturation age sex education associated healthy unhealthy dietary patterns nutrition interventions mexican americans tailor approaches characteristics
background prior studies suggested inhibited temperament may associated increased risk developing anxiety mood disorder including bipolar disorder however neurobiological basis increased risk unknown aim study examine temperament symptomatic asymptomatic child offspring parents bipolar disorder obd investigate whether inhibited temperament associated aberrant hippocampal volumes compared healthy control youth methods obd group consisted youth current psychiatric symptoms obd without psychiatric symptoms obd compared youth temperament characteristics measured using revised dimensions temperament survey magnetic resonance imaging used measure hippocampal volumes association temperament hippocampal volumes tested using multiple regression analysis results compared obd group obd group significantly inhibited temperament traits less flexibility negative mood less regular rhythm daily routines contrast obd group likely approach novel situations compared obd groups within obd group inhibited temperament associated smaller right hippocampal volumes conclusions study symptomatic obd characterized inhibited temperament inversely correlated hippocampal volume additional longitudinal studies needed determine whether inverse correlations hippocampal volume inhibited temperament represent early markers risk later developing bipolar disorder
context software process improvement spi one type innovation often formulated address problems uncontrollable costs schedule overruns poor end product quality study investigates spi application knowledge management software project level viewing applied software development complementary spi objective study advances use spi investigating impediments use flow knowledge within individual software development project proposition removal obstacles project level knowledge flow flow enhance spi investigate proposition exploring problems associated project flows seen software project team members method conducted descriptive case study industrial software development project collected data concerning project knowledge sources flows using semi structured interviews using data constructed diagnostic project knowledge map map map analyzed identify flow obstacles potential solutions questionnaires based obstacles solutions formulated probe software engineers perceptions effect solutions spi results findings participant questionnaires reveal software engineers perceive removal mitigation project level flow obstacles generally reduces time perform work helps meet deadlines improves work quality thus resulting spi conclusions study provides support usefulness project level flow obstacle removal spi provides unique project level perspective using input project software engineers also explains supports use mapping identification project level flow obstacles approach practitioners gain insight spi real time project executed insights may help enhance current future spi efforts elsevier rights reserved
modeling usual analysis mechanical structures considered whole structure components accomplish one fundamental conditions strength materials condition continuity homogeneity paper presents modeling techniques useful optimization numerical models order improve structural response impact applications parts damaged material model capable material failure must used differences results obtained using model without failure model failure compared experiments discussed second procedure regarding random distribution thickness properties elements selected area within user specified tolerance procedures implemented custom written code algorithms presented random distribution presented
background understand impact radiotherapy development myelodysplastic syndromes mds acute myeloid leukemia aml among elderly prostate cancer patients methods performed retrospective cohort study elderly prostate cancer patients diagnosed using national cancer institute surveillance epidemiology end results medicare linked database competing risk analyses adjusting patient characteristics conducted assess impact radiotherapy development subsequent mds aml compared surgery results prostate cancer patients underwent radiotherapy received surgery median follow years total prostate cancer patients developed subsequent mds aml median time develop mds aml range years compared prostate cancer patients received surgery patients underwent radiotherapy significantly increased risk developing mds aml hazard ratio confidence interval radiotherapy categorized modalities brachytherapy conventional conformal radiotherapy intensitymodulated radiotherapy imrt increased risk second mds aml observed imrt group conclusions findings suggest radiotherapy prostate cancer increases risk mds aml impact may differ modality additional studies longer follow needed clarify role radiotherapy development subsequent myeloid malignancies better understanding may help patients physicians stakeholders make informed treatment decisions wiley periodicals inc
electric motors power drive systems convert nearly half worldwide electric energy mechanical energy ultimately used final application process overall motor driven system optimization key approach effectively achieve highest system efficiency levels given investment looking individually component may lead cost effective option terms investment part paper overview motor driven system optimization presented looking relevant related standards commercial technologies energy consumption reduction strategies collection practical examples also presented part overview international standards associated high efficiency technologies power drive systems presented part energy savings potential associated output power reduction regeneration addressed
internal combustion engine research alternative fuels gained momentum growing awareness energy security environmental issues worldwide biodiesel offers ideal solution problems excellent partial replacement mineral diesel study karanja biodiesel blended mineral diesel investigated macroscopic spray characterization vis vis baseline mineral diesel varying fuel injection pressures mpa spray developed relatively narrower spray angle injector needle movement energizing real injection durations also compared diesel fuel injection pressures mpa needle movement slightly higher relatively higher viscosity however increasing fuel injection pressure difference reduced showed quite similar results common rail direct injection sport utility vehicle euro diesel engine used experiments engine performance emissions combustion characteristics compared baseline mineral diesel rated engine speed min varying engine loads well rated load varying engine speeds min brake thermal efficiency lower mineral diesel brake specific carbon monoxide carbon dioxide emissions decreased increasing brake mean effective pressure showed increasing trend increasing engine speeds showed emission higher number particles compared mineral diesel engine operating conditions higher oxygen content biodiesel resulted shorter ignition delay slightly higher peak cylinder pressure showed relatively longer combustion duration compared mineral diesel min engine speed
study adopted social ecological perspective exploring perpetration serious physical violence others among arab palestinian adolescents total adolescents aged completed anonymous structured self report questionnaire included selected items several instruments measured variables relating constructs examined study explored association individual characteristics age gender normative beliefs violence perceived ethnic discrimination familial characteristics parent adolescent communication socioeconomic status contextual characteristics exposure community violence neighborhood perpetration serious physical violence others moderation mediation model tested adolescents reported perpetrated serious physical violence others least month preceding study findings also show exposure youth violence neighborhood correlated significantly positively perpetration serious physical violence others similar trend revealed respect personal perceptions ethnic discrimination correlations mediated adolescents normative beliefs violence furthermore correlation direct exposure violence neighborhood normative beliefs violence perpetration serious physical violence others stronger among adolescents poor communication parents among strong parental communication elsevier ltd rights reserved
hybridization heavy highway working vehicles brings considerable energy savings form downsized internal combustion engine ice means reduced load losses paper novel energy saving opportunity working hydraulics end long booms working vehicles proposed traditional highway working vehicles working hydraulics supplied pipes hoses valves hydraulic pump located near main engine significant amount energy lost long pipelines hoses well valve throttles new topology introduced supply power along long boom power hydraulic actuator supplied integrated electro hydraulic energy converter iehec located boom end electrical energy converter supplied electrical cables negligible losses compared conventional fluid power supply long pipelines converter transforms electrical energy hydraulic energy end boom may also recover energy additional energy savings elsevier rights reserved
background goal research establish possible predictive factors subjective externally assessed quality life people chronic schizophrenia methods sixty eight people schizophrenia took part study assessed using world health organisation quality life assessment brief version whoqol bref quality life scale qls positive negative syndrome scale schizophrenia panss global assessment functioning gaf social functioning scale sfs tests correlations multiple regression analysis conducted determine possible predictors quality life results residential environment rural urban diagnosis age onset disorder global functioning social functioning explained total variance based proxies assessment quality life living arrangements social functioning emerged predictor variables subjective quality life explaining total variance conclusions socio cultural factors social integration quality interpersonal relationships influence peoples physical psychological health certain personal factors psychopathology therefore advisable pay attention environment macro systemic variables developing intervention plans improve quality life
study examined effect using ipad students autism spectrum disorder asd self monitoring behaviors class four students asd taught task behaviors watching self modeled video saved application choiceworks ipads collected data behaviors single subject research design abab phases used student behaviors observed using interval recording behavioral occurrences compared across phases results showed participating students task behaviors facing forward looking teacher eye contact working assignment increased ipad used self monitoring
power system monitoring problem asks possible measurement devices put electric power system problem graph theory model involving power dominating set graphs concept power domination first introduced chang discret appl math common generalization domination power domination paper present linear time algorithm power domination block graphs
research work regards design realization absorption spectrophotometer based led light source place usually employed xenon lamp advantage use led technology resides several factors reducing analyte temperature variations thus noise generation occur xenon light source used beside high luminous efficiency reliability operating duration lower maintenance lower power consumption last factor allows supply entire designed apparatus using solar panel thus making system easly portable use even places electricity network absent optical filtering system realized order detect analyte absorption wavelength range selected optical filters interfaced pic based control unit used manage different functionalities required spectophotometer realized tested control unit acquires processes via developed firmware raw data provided different sensors employed system sensors used monitor analyte temperature humidity values control analyte pressure acquire luminous intensity value light beam passing analyte finally realized electronic control unit actuates different mechanical sections stepper motor solenoid valve sincronyzing controlling data exchange hardware sections microcontroller
analyze selection high efficiency windows builders new housing units united states windows among five important technologies impacting energy use structures focusing windows provides insights decisions result energy efficient houses factors affecting decisions muted completely missed looking building ratings aggregated estimates study analyzes large data set continental united states applying least absolute shrinkage selection operator lasso model selection cross validation training set model randomly selected validation data set findings strongly support importance climate energy costs decisions energy efficient housing important smaller effects public policies incentives also find taxing insurance policies increase overall costs construction negative impacts diffusion energy efficient products elsevier rights reserved
present study undertaken investigate influence apneas rem elicited dream reports examine influence clinically successful treatment apneas dreaming thirty three volunteers suffering sleep apnea syndrome sas slept two nights sleep laboratory sixteen treated nasal continuous positive air pressure cpap first night second total awakenings rem sleep without apneas rem sleep apneas apneas dream recall tended higher dream reports significantly longer words words healthy sleep systematic incorporation apnea stimulus dream reports could demonstrated dreams apneas found significantly negative dreams healthy sleep suggests rem elicited dreams basically resistant powerful internal stimulation stress caused apneas exerted global emotional influence manifest dreaming
brain gut axis comprises interactions brain spinal cord sympathetic parasympathetic enteric divisions autonomic innervation digestive tract intestinal microbiome metabolites bidirectional communication enables effective treatment method functional gastrointestinal disorders irritable bowel syndrome functional dyspepsia namely gut directed hypnosis series randomized controlled studies show remarkable long term success even therapy refractory complaints gut directed hypnosis therefore recommended included guidelines treatment irritable bowel syndrome performed individual group settings sessions well integrated treatment concept gastroenterological centers well also indications efficacy children functional bowel diseases preliminary studies indicate hypnosis may additive therapy effect conventional medical treatment inflammatory bowel diseases
paper present novel electromagnetic actuation scheme nanoscale positioning six axis magnetic levitation maglev stage whose position resolution extended travel range plane describe conceptualization actuation scheme calculation forces experimental verification detail actuation scheme enables application forces two perpendicular directions moving permanent magnet using two stationary current carrying coils magnetic flux generated magnet shared two coils one right another one side magnet magnitudes directions currents coils govern forces acting magnet following lorentz force law analyzed calculated electromagnetic forces moving magnet large travel range used feedback linearization eliminate force gap nonlinearity actuation new actuation scheme makes maglev stage simple manufacture assemble also mechanical constraint single moving platen remove assembly three ndfeb magnets used generate actuation forces six axes reduces moving part mass significantly leads less power consumption heat generation entire maglev stage present experimental results demonstrate payload precision positioning capabilities maglev nanopositioner abruptly continuously varying loads potential applications maglev nanopositioner include microfabrication assembly semiconductor manufacturing nanoscale profiling nanoindentation
novel first order pass current mode filter realized employing minimum number discrete ota components introduced paper attractive characteristics proposed topology requirement grounded capacitor high output impedance experimental results confirm correct operation novel pass filter topology
objectivesthe development novel agents ageing population led increasing number patients follicular lymphoma living longer disease health related quality life hrqol priority patients guide clinical decisions myeloma patient outcome scale mypos originally developed myeloma validated cross sectional survey recruiting patients methodscontent construct validity structural validity using confirmatory factor analyses reliability acceptability evaluated resultsthree subscales indicated symptoms function emotional response healthcare support mypos symptom function scores higher worse participants poorer ecog performance status discriminated patients treatment good convergent discriminant validity comparison eortc qlq fact lym demonstrated internal consistency good coefficient total mypos score subscales conclusionthe mypos valid reliable acceptable used support clinical care patients first measurement tool developed specially use clinical practice validated use people longitudinal validation required support use outcome measurement
curriculum wide initiative enrich course content increase student engagement experiential learning adoption new learning modalities underway department mechanical manufacturing engineering miami university projects entail development online learning modules interweave experimental computational analysis modules incorporate multimedia content prepared undergraduate graduate enable easy uploading updating material distinctive feature comex studios thematic linking content allows used multiple classes progressive advancement technical content paper presents details studio model motivation methodology implementation assessment learning modules utilized faculty introduce new lab derived content may related research traditional class course format additional benefits modules include ability independently review specific topics preparation advanced courses research project assessment efficacy modules performed students surveys completed online four external faculty reviewers continuous improvement modules underway
american college cardiology society cardiovascular angiography interventions society thoracic surgeons american association thoracic surgery along key specialty subspecialty societies completed part revision appropriate use criteria auc coronary revascularization prior coronary revascularization auc documents indications revascularization acute coronary syndromes stable ischemic heart disease sihd combined document address expanding clinical indications coronary revascularization align subject matter current american college cardiology american heart association guidelines new auc coronary artery revascularization separated documents addressing sihd acute coronary syndromes individually document presents auc sihd clinical scenarios developed mimic patient presentations encountered everyday practice scenarios included information symptom status risk level assessed noninvasive testing coronary disease burden scenarios fractional flow reserve testing presence absence diabetes syntax score update provides reassessment clinical scenarios writing group felt affected significant changes medical literature gaps prior criteria methodology used update similar initial document employs recent modifications methods developing auc notably alterations nomenclature appropriate use categorization separate independent rating panel scored clinical scenarios scale scores indicate revascularization considered appropriate clinical scenario presented scores indicate revascularization considered rarely appropriate clinical scenario whereas scores mid range indicate coronary revascularization may appropriate clinical scenario seen prior coronary revascularization auc revascularization clinical scenarios high symptom burden high risk features high coronary disease burden well patients receiving antianginal therapy deemed appropriate additionally scenarios assessing appropriateness revascularization kidney transplantation transcatheter valve therapy rated primary objective auc provide framework assessment practice patterns hopefully improve physician decision making
solid modeling technology basic virtual model virtual reality well core element cad system quickly become mainstream thecad technology computational geometry use computer transform synthesize analyze physical geometry information modeling technology divided following three types point line modeling technology plane modeling technology solid modeling technology
deductive logic essential complete understanding computer science concepts thus fundamental computer science education intelligent tutoring systems individualized instruction shown increase learning gains seek improve way deductive logic taught computer science developing intelligent data driven logic tutor augmented deep thought existing computer based logic tutor adding data driven methods specifically intelligent problem selection based student current proficiency automatically generated demand hints determination student problem solving strategies based clustering previous students result student tutor completion amount tutor students completed steadily improved data driven methods added deep thought allowing students exposed logic concepts also gained additional insights effects different course work teaching methods tutor effectiveness
kiribati pacific island country striving high solar electricity national grid order reduce unsustainable dependence imported fossil fuel however pose technical challenges reliable operation small isolated system work technical analysis carried investigate implications planned pipeline grid connected systems kiribati tarawa power system variations output corresponding spinning reserve requirements balance short fall power output analysed utility network modelled using powerfactoty software steady state dynamic analyses carried simulated scenarios major concerns identified times high load high output low system demand high output dispatch constraints identified current grid system sustain maximum capacity load require curtailment load dynamic simulations showed fast negative ramps output lead frequency instability time low demand maximum output system stable curtailed low loads maximum output conditions exist elsevier ltd rights reserved
wind energy seen tremendous growth electricity generation worldwide reached end june according world wind energy association global wind power reach end africa continent possesses huge utilized wind potentials african countries morocco egypt tunisia south africa already adopted wind alternative power generation source energy mix among countries south africa invested heavily wind energy operational wind farms supplying gwh annually national grid however two african countries cameroon nigeria vast potentials currently lagging behind wind energy development nigeria slow implementation renewable energy policy visible operational wind farms cameroon policy plan wind power issues severely hindering direct foreign local investments electricity sector cameroon nigeria huge wind energy potentials similar climatic conditions benefit greatly huge success recorded south africa terms policy implementation research development technical considerations therefore paper reviews wind energy potentials policies future renewable energy road maps cameroon nigeria identifies strength weakness well providing necessary actions future improvement south africa already adopted
weaknesses nature rater judgments generally considered compromise utility workplace based assessment wba order gain insight underpinnings rater behaviours investigated raters form impressions make judgments trainee performance using theoretical frameworks social cognition person perception explored raters implicit performance theories use task specific performance schemas formation person schemas wba used think aloud procedures verbal protocol analysis investigate schema based processing experienced inexperienced raters supervisor raters general practice residency training qualitative data analysis used explore schema content usage quantitatively assessed rater idiosyncrasy use performance schemas investigated effects rater expertise use task specific performance schemas raters used different schemas judging trainee performance developed normative performance theory comprising seventeen inter related performance dimensions levels rater idiosyncrasy substantial unrelated rater expertise experienced raters made significantly use task specific performance schemas compared inexperienced raters suggesting differentiated performance schemas experienced raters raters started develop person schemas moment began observe trainee performance findings understanding processes underpinning judgment decision making wba raters make justify judgments based personal theories performance constructs raters information processing seems affected differences rater expertise results study help improve rater training design assessment instruments decision making wba
crack initiation cantilevered beam subject harmonic excitation near beam second natural frequency determined using nonlinear model tracking nmt health monitoring technique method assumes second order nonlinear differential equation model cubic stiffness nonlinear parameter tracked catastrophic failure using continuous time based system identification previous research shown significant change value nonlinear parameter indicates system transition healthy unhealthy study introduced gaussian noise raw stimulus response data various signal noise ratios results compared original data highlight technique effectiveness determining change system health model robustness also investigated exciting system range frequencies near resonance results test compared results excitation single frequency new methods identifying crack formation beam also implemented raw acceleration response data plotted next nonlinear parameter real time system natural frequency recorded crack initiation
background use cannabis illegal drugs particularly prevalent male young adults associated severe health problems longitudinal study explored variables associated onset cannabis use onset illegal drug use cannabis separately male young adults including demographics religion religiosity health social context substance use personality furthermore explored far gateway hypothesis common liability addiction model line resulting prediction models methods data gathered within cohort study substance use risk factors surf young men aged around years provided demographic social health substance use personality related data baseline onset cannabis drug use assessed months follow samples individuals indicated baseline used cannabis drugs respectively life provided follow data used prediction models hierarchical logistic stepwise regressions conducted order identify predictors late onset cannabis drug use separately results providing oneself siblings depressiveness parental divorce lower parental knowledge peers whereabouts peer pressure low nicotine dependence sensation seeking positively associated onset cannabis use practising religion negatively associated onset cannabis use onset drug use cannabis showed positive association depressiveness antisocial personality disorder lower parental knowledge peers whereabouts psychiatric problems peers problematic cannabis use sensation seeking conclusions consideration predictor variables identified within study may help identify young male adults preventive measures cannabis drug use appropriate results provide evidence gateway hypothesis common liability addiction model point variables like depressiveness practising religion might influence onset drug use
users currently expected benefit concurrent use different computing devices applications personal computers easier content production mobile devices increased mobility context awareness wearable devices transparent health related data acquisitions etc however simultaneous use different devices applications could perceived disruptive unproductive due need additional settings lack integration etc first step overcome problem paper introduce notion continuous interaction coin systems systems intend promote simultaneous use multiple devices applications complete tasks effective flexible easy way achieve goal set human centred design principles figured enable users seamlessly share tasks across multiple devices independently software applications supporting completion case study mobile forensic workspace mfw presented highlight benefits coin systems could bring ambient intelligence ami ubiquitous computing research fields
issue addressed important strategy increasing children physical activity enhance children opportunities school recess physical activities yet little isknown influence school recess physical activitieson children health related quality life hrqol purpose present study explore relationship australian primary school children enjoyment recess physical activities hrqol methods study consisted children two australian primary schools aged years lunchtime enjoyment activity play questionnaire used measure school children enjoyment school recess physical activities pediatric quality life inventory used measure children hrqol researchers applied linear regression modelling stata ver investigate relationship children enjoyment school recess physical activities hrqol results discovered primary school children enjoyment vigorous type school recess physical activities playing range weather conditions associated children improved hrqol conclusion findings study suggest health providers researchers consider providing primary school children opportunities facilities vigorous intensity school recess physical activities key strategy enhance children hrqol considering social ecological model framework key predictors children enjoyment school recess physical activities may provide valuable insight school health providers multiple levels influence children hrqol developing school settings activities school recess
envelope tracking envelope elimination restoration eer techniques gained importance last decade order obtain highly efficient radio frequency power amplifier transmits signals high peak average power ratio study multilevel multiphase buck converter presented solution envelope amplifier used eer presented multiphase buck converter generates multilevel voltage using node duty cycles nonlinear control way multilevel implemented using one simple power stage however complexity multilevel converter implementation shifted complicated power topologies complicated digital control detailed discussion regarding influence design parameters switching frequency output filter time resolution digital control performance proposed envelope amplifier presented design output filter conducted fulfilling constraints envelope slew rate minimum driver pulse reproduced cases two constraints fulfilled may relieved modified control presented experimentally validated finally order validate concept prototype designed integrated nonlinear class amplifier efficiency measurements showed employing eer possible save power losses comparing case supplied constant voltage additionally adjacent channel power ratio measured obtained results showed value higher signals mhz bandwidth without using predistortion technique
high maternal mortality ratios mmrs serve objective indicators poor condition women health country point violations human rights entrenched national regional global laws decade nigeria consistently one top five listed countries highest mmrs world mmr estimated deaths per live births accounting maternal deaths worldwide approximately deaths year accountability preventable maternal deaths injuries essential achieve sustain reduction nigeria high levels maternal mortality present article addresses key human rights strategies securing accountability identifies opportunities healthcare providers leadership roles fulfilment legal ethical obligations preserve women lives
cancer cell metabolism complex dynamic network regulated pathways interrogation network would benefit rapid sensitive techniques adaptable high throughput formats facilitating novel compound screening requires assays minimal sample preparation adaptable lower volume well formats automation describe bioluminescent glucose lactate glutamine glutamate detection assays well suited high throughput analysis two major metabolic pathways cancer cells glycolysis glutaminolysis sensitivity pmol sample broad linear range wide dynamic range fold advantageous measuring extracellular intracellular metabolites importantly assays incorporate rapid inactivation endogenous enzymes eliminating deproteinization steps required methods using ovarian cancer cell lines model system assays used monitor changes glucose glutamine consumption lactate glutamate secretion time homogeneous formats lactate glutamate assays robust could multiplexed real time viability assay generate internally controlled data screening small compound library assays resulted identification inhibitors activators lactate glutamate production
present paper summarizes results numerical calculations carried basis recent wide experimental research calculations performed axisymmetric specimens weakened notches consisting large bulk different shapes specimens subjected multiaxial fracture loading tension torsion stress strain fields whole specimens evaluated herein using finite element method fem special attention paid changing distribution stresses induced loading notch shape taking advantage numerical calculations carried present investigation new non local fracture criterion notched specimens multiaxial loading proposed successfully employed compared data taken recent literature published elsevier ltd
although quality life qol one important considerations patients treated anticancer therapies desirable regimens neoadjuvant chemotherapy including qol locally advanced urothelial carcinoma remain unclear present study evaluated influence neoadjuvant platinum based chemotherapy qol patients locally advanced urothelial carcinoma june march urothelial carcinoma patients received two courses neoadjuvant chemotherapy enrolled prospective observational study neoadjuvant regimens included gemcitabine cisplatin gcis gemcitabine carboplatin gcb therapies primary endpoint assessed qol changes group chemotherapy using quality life questionnaire days cycle secondary endpoints included toxicity safety weight loss renal function decline tumor responses qol analyses performed patients receiving gcis patients receiving gcb appetite loss role functioning nausea vomiting physical fatigue deteriorated baseline gcis group gcb group constipation worsened whereas scores pain emotional items improved groups objective response rates gcis gcb groups respectively gcis gcb regimens feasible terms qol gcb regimen may associated better qol status especially regard gastrointestinal symptoms
paper proposes fractional order pid fopid controller improve positioning ability conducting polymer actuators cpas novel class smart material based actuators controller design process performance requirements constraints crucial precise positioning cpas fast settling time low steady state error overshoot control voltage considered order obtain optimal controller parameters cuckoo search particle swarm optimization pso meta heuristic search methods utilize fractional order model cpa specifically defined fitness function used algorithms compared terms convergence rate success converging optimal solution order test performance fopid controller pid controller also tuned algorithms controllers implemented experimentally cpa results show fopid controller tuned csa provided less overshoot settling rise time tuned pso performance pid control slightly worse fopid controllers terms transient steady state response although search algorithms satisfied control input constraint fopid pid controllers csa tuned pid controller required smallest control signal elsevier ltd rights reserved
epithelial lining gastrointestinal tract major interface external world gut lumen body proper maintenance regulation epithelial barrier function key determinant digestive health host well many enteropathies associated increased gut permeability including inflammatory bowel disease ibd maintaining barrier function epithelium independent whether paracellular transcellular permeation pathways considered energy dependent process present overview impact metabolic stress reductions epithelial atp synthesis permeability characteristics epithelial monolayers show metabolic stress presence commensal flora results significant loss epithelial integrity increase epithelial permeability enhanced presence tumor necrosis factor alpha tnf alpha speculate combination factors vivo would result significant perturbations epithelial barrier function could pathophysiological significance contribute initiation ibd induction disease relapses
present work use sequence two solar photocatalytic processes investigated removal copper iron zinc ethylenediaminedisuccinic acid edds used chelating agent real soil washing effluents removal efficiencies copper iron zinc edds toc achieved outdoor solar photocatalytic treatments using parabolic trough collectors carried naples italy degrees degrees period june july removal efficiencies achieved incident uva solar energy per unit volume calculated taking account irradiated surface area photoreactor estimated present work solar irradiance measurements collected experiments results suggest two step solar process adopted proposed useful solution problem heavy metals chelating organic agents removals soil washing ecotoxicological assessment using different living organisms daphnia magna vibrio fischeri pseudokirchneriella subcapitata lepidium sativum caenorhabditis elegans showed noticeable decrease ecotoxicity soil washing effluents two step photocatalytic process elsevier rights reserved
study intends investigate correlations mir mir clinicopathological features breast cancer patients type diabetes mellitus tdm total patients tdm diabetic group patients without tdm non diabetic group enrolled study blood glucose detected glucose oxidase methods glycosylated hemoglobin hbac measured high performance liquid chromatography fasting insulin fins measured chemiluminescent microparticle immunoassay automatic biochemical analyzer used detect triglyceride total cholesterol high density lipoprotein cholesterol hdl low density lipoprotein cholesterol ldl estradiol detected radioimmunoassay homeostasis model assessment applied assess insulin resistance homa beta cell insulin secretion homa expressions mira mir measured quantitative real time polymerase chain reaction qrt pcr significant differences age ratio menopause body mass index bmi hdl plasma glucose hpg fins hbac homa homa diabetic non diabetic groups diabetic group higher incidence lymph node metastasis non diabetic group mir expression regulated mir expression regulated patients tdm correlation analysis showed mira expression positively correlated hdl negatively correlated age hbac ldl however mir expression negatively correlated hdl positively correlated age hbac ldl conclusion mir mir may correlated clinicopathological features patients tdm mir mir could serve novel biomarkers early diagnosis patients tdm
background purpose awareness demand neurological expertise global health emerged recent years become relevant due increasing numbers refugees developing countries arriving europe study aimed assess provision education opportunities international exchange neurology post graduate training focus europe methods developed questionnaire covering different aspects interest education behalf european association young neurologists trainees residents neurology junior neurologists rjn approached complete survey results completed questionnaires returned rjns women years old total almost one third rjns reported residency programs offered training limited education reported women children health neurological disorders immigrants refugees rjns reported training offered respectively curriculum rarely included coverage global impact neurological disorders definite plans volunteer developing country reported majority participants acknowledged importance training international exchange post graduate education conclusion survey corroborates interest appreciation education european rjns however shortcomings training opportunities international exchange academic neurology international bodies including european academy neurology requested address
background eating disorders eds thought result combination environmental psychological stressors superimposed genetic vulnerability neurobiological basis eds remains incompletely understood recently reported rare missense mutation gene transcriptional repressor histone deacetylase hdac associated risk developing humans methods understand biological consequences missense mutation created transgenic mice carrying mutation introducing alanine threonine mutation position mouse hdac corresponding position human protein bioinformatic analysis identify hdac regulated genes performed using available databases results male mice heterozygous hdac show metabolic behavioral differences contrast female mice heterozygous hdac display several related feeding behavioral deficits depending housing condition individually housed hdac female mice exhibit reduced effortful responding high fat diet compulsive grooming whereas group housed female mice display increased weight gain high fat diet reduced behavioral despair increased anxiety like behaviors bioinformatic analysis identifies mitochondrial biogenesis including synthesis glutamate gamma aminobutyric acid potential transcriptional target hdac activity relevant behavioral deficits identified new mouse model disordered eating conclusions hdac mouse line novel model related behaviors identifies mitochondrial biogenesis potential molecular pathway contributing behavioral deficits
due marked differences material properties combustion characteristics hydrogen carbon based fuels increased heat flux inside cylinder hydrogen fuelled internal combustion engines occurs present study aims simulation model describes wall heat transfer within entire range engine calibration possibilities conducted experiments hydrogen engine equipped temperature sensors provide base present study using surface temperature method highly resolved instantaneous surface heat fluxes identified measurements compared results published heat transfer models originally developed conventional fuels satisfying result models obtained hydrogen engine modified heat transfer model derived validated based experimental data necessary developments characteristic model features lead distinctive model hydrogen engine demonstrated proposed model attains consistently high prediction quality broad range engine calibration variabilities elsevier ltd rights reserved
paper introduces kind receiver receive signal weak level first common mode rejection input differential signal necessary low noise amplifier followed let signal programmable filter whose center frequency selected via pin strapped inputs order get appropriate amplitude signal automatic gain control amplifier needed last signal sampled converters active filter operational amplifier followed agc amplifier actual test low frequency signal receiver high sensitivity introduced paper characteristics high sensitivity stability applied engineering
first fully integrated cmos imaging sensor chip signal processing applications laser doppler blood flow ldbf imaging designed tested obtain space efficient design pixels means standard processing electronics used chip implemented therefore analog signal processing pixel tailored design ldbf signals balanced optimization signal noise ratio silicon area custom made sensor offers key advantages conventional sensors viz analog signal processing pixel level carries signal normalization amplification combination anti aliasing filter allows analog digital conversion low number bits low resource implementation digital processor enables chip processing data bottleneck exists detector processing electronics overcome sensor demonstrates good agreement simulation design stage measured optical performance sensor demonstrated using modulated light signals vivo blood flow experiments images showing blood flow changes arterial occlusion inflammatory response histamine skin prick demonstrate sensor array capable detecting blood flow signals tissue
series sio aluminum mof mil composites different sio loadings synthesized simple mild compositing strategy high efficiency removal aniline evidenced sem tem images well particle size distribution incorporation sio improve dispersity mil composites result smaller particle size pristine mil besides adsorption aniline sio mil physical mixture two materials sio mil composites investigated comparatively demonstrating relatively high adsorption capacity sio mil towards aniline combining ultrafast adsorption dynamics reaching equilibrium within great reusability sio mil shows excellent adsorption performance indicates sio mil composites possess great potential applications kind fascinating adsorbent water pollution protection elsevier rights reserved
paper multiple exp function method employed investigate exact multiple wave solutions dimensional potential kadomtsev petviashvili equation dimensional jimbo miwa equation already known multiple wave solutions recovered also several new general multiple wave solutions obtained elsevier ltd rights reserved
herein report year old japanese woman evolving hypopituitarism due pituitary stalk transection syndrome history short stature treated growth hormone childhood hypothyroidism primary amenorrhea years old levothyroxine replacement recombinant follicle stimulating hormone human chorionic gonadotropin fsh hcg therapy ovulation induction started replacement therapy ghrt resumed years old developed mild adrenocortical insufficiency years old succeeded becoming pregnant delivered twice ghrt partially continued pregnancy stopped end second trimester without complications
work presents novel variable speed generator system double generator system hydropower plants consists two synchronous machines superposition gearbox inverter one synchronous machines coupled directly grid connected inverter stabilization system regulation turbine desired speed achieved control latter synchronous machine due specific construction investment hydropower plants reduced dynamic behavior step responses characterizes system properties firstly equations describe total system presented equations linearized operating point controller designed finally stability system control behavior examined method state space representation
sex linkage predicted evolve response sex specific sexually antagonistic selection line prediction sex linked genes associated reproduction respective sex addition traits directly involved fertility fecundity mediators maternal effects may predisposed evolve sex linkage indirectly affect female fitness effect offspring phenotype test sex linked inheritance key mediator prenatal maternal effects oviparous species transfer maternally derived testosterone eggs consistent maternal inheritance found japanese quail coturnix japonica granddaughters resemble maternal paternal grandmother yolk testosterone deposition pattern resemblance due non genetic priming effects testosterone exposure prenatal development experimental manipulation yolk testosterone levels affect females testosterone transfer eggs later life instead chromosome mitochondrial variation may underlie observed matrilineal inheritance pattern ultimately inheritance mediators maternal effects along maternal line allow fast direct response female specific selection thereby affecting dynamics evolutionary processes mediated maternal effects
technology virtual reality result progress science technology since century embodied computer technology computer graphics multimedia technology sensor technology display technology human body engineering human computer interaction theory latest achievements artificial intelligence fields become latest achievements relay information field multimedia technology network technology widely attention research development application hot spots currently fastest growing multi disciplinary comprehensive technology rapid generating equipment interaction changed past people computer dull stiff passive way communication make man machine interaction become humanized blazed new research field human computer interaction interface provides new interface application intelligent engineering tools kinds engineering provides new description method large scale data visualization also changed way people work lifestyle ideology
background american indian experience historical trauma thought source inter generational trauma responses well potential causative factor long term distress substance abuse among communities aims present study evaluate extent frequency thoughts historical loss associated symptoms influenced current traumatic events post traumatic stress disorder ptsd cultural identification percent native american heritage substance dependence affective anxiety disorders conduct disorder antisocial personality disorder aspd methods participants american indians recruited reservations assessed semi structured assessment genetics alcoholism ssaga historical loss scale historical loss associated symptoms scale quantify frequency thoughts symptoms historical loss stressful life events scale assess experiences trauma orthogonal cultural identification scale ocis results three hundred six american indian adults participated study half indicated thought historical losses least occasionally caused distress logistic regression revealed significant increases often person thought historical losses associated married high degrees native heritage high cultural identification additionally anxiety affective disorders substance dependence correlated historical loss associated symptoms conclusions american indian community thoughts historical losses associated symptomatology common presence thoughts associated native american heritage cultural identification substance dependence elsevier ireland ltd rights reserved
red eye used general term describe irritated bloodshot eyes recognizable sign acute chronic localized systemic underlying inflammatory condition conjunctival injection commonly caused dryness allergy visual fatigue contact lens overwear local infections instances red eye represent true ocular emergency treated ophthalmologist comprehensive assessment red eye conditions required preserve patients visual function severe ocular pain significant photophobia decreased vision history ocular trauma warning signs demanding immediate ophthalmological consultation
introduction effectiveness lantibiotics mdr pathogens progression agents nai nvb duramycin pre clinical clinical trials highlighted potential fight bacterial resistance number known lantibiotics knowledge biosynthetic pathways increased recent years due higher quality genomic data delivered next generation sequencing technologies combined development specific genome mining tools enabling prediction lantibiotic clusters areas covered review author describes increase high quality genomic data increased discovery novel lantibiotics expert opinion novel apparatus ichip enabling isolation uncultable bacteria undoubtedly increase identification rate novel antimicrobial peptides including lantibiotics ability assess lantibiotic clusters via recombinant production synthesis using high throughput method one next challenges developing agents clinical environment
study problem indexing text whenever pattern interval alpha beta come query report pairs consecutive occurrences alpha beta present logn space data structure optimal query time output size elsevier rights reserved
markov random field mrf model attracted great attention field image segmentation however mrf based methods fail resolve segmentation misclassification problems high spatial resolution remote sensing images due insufficiently using hierarchical semantic information order solve problem paper proposes object based mrf model auxiliary label fields capture macro detailed information apply semantic segmentation high spatial resolution remote sensing images specifically apart label field two auxiliary label fields first introduced proposed model interpreting remote sensing images different perspectives implemented setting different number auxiliary classes multilevel logistic model used describe interactions within label field conditional probability distribution developed model interactions label fields net context structure established among model interactions classes within label fields principled probabilistic inference suggested solve proposed model iteratively renewing label field auxiliary label fields different information auxiliary label fields integrated label field iterations experiments different remote sensing images demonstrate model produces accurate segmentation state art mrf based methods prior information added proposed model produce accurate results even complex areas
time resolved particle image velocimetry mie scattering fuel droplets khz used capture simultaneously temporal evolution cylinder flow field spray formation within direct injection spark ignition engine engine operated stratified combustion mode stratified mixtures created triple injection late compression stroke impact geometric variation intake port cylinder flow flow spray interactions investigated focusing second injection since provides ignitable mixtures time ignition subject strong fluctuations rather first injection reproducible flow field statistics conditioned spray shape second injection revealed regions macroscopic cycle cycle flow variations correlated spray recorded cycles flow spray interaction traced back first injection using correlation analysis revealed cycle cycle fluctuations large scale tumble vortex big impact spray shape second injection first injection unaffected indicates origin spray fluctuations may intake despite significant flow modifications due intake port geometry variation fluctuation levels second injection geometries spray fluctuations sensitive geometric change
purpose review psoriasis common chronic inflammatory skin disease driven immune dysregulation involving helper cell pathways psoriasis associated systemic inflammation increases risk joint disease psoriatic arthritis subclinical cardiovascular disease major adverse cardiovascular events especially young patients severe skin disease furthermore vascular inflammation fluorodeoxyglucose positron emission tomography computed tomography fdg pet provides valuable tool utility predicting future cardiovascular events psoriasis provides clinical human model characterize vascular disease non invasive imaging techniques vascular inflammation fdg pet recent findings fdg pet garnered considerable interest multiple completed ongoing cardiovascular psoriasis trials indeed recent studies shown psoriasis associated increased vascular inflammation furthermore dose response demonstrated severity skin disease severity vascular inflammation psoriasis additionally observational studies reported treatment psoriasis decreases vascular inflammation several randomized trials still ongoing emerging data single report demonstrated use fdg pet mri may provide soft tissue localization fdg tracer aorta carotids larger studies underway summary review outlines initial use development current utility fdg pet psoriasis covering cross sectional longitudinal studies examined relationship psoriasis severity skin disease presence joint disease treatment skin disease emerging techniques identify vascular inflammation marker cardiovascular risk psoriasis
consultation competency critical component health services psychology training consultation permeates aspects service delivery despite increasing importance consultation form service delivery school based preservice level consultation training historically lacked rigor many components training may contribute psychology graduates confidence consult schools purpose study investigate contribution specific consultation training components coursework competencies included training field experiences supervision models development confidence consult early career school psychology practice data collected part larger study early career school psychologists consultation training practices bivariate correlations repeated measures analysis variance multiple regression model estimated fulfill purpose study results indicated exposure given consultation models positively correlated confidence consulting different types consultees respondents varying levels confidence consulting different types consultees quantity coursework supervision strategies exposure formal consultation models emerged significant predictors confidence consult graduation recommendations consultation training include coverage systems level consultation team based consultative problem solving increasingly common contexts consultation contemporary schools implementation applied experiences supervision tandem development consulting confidence inclusion formal models consultation consultation training limitations study suggestions future research discussed
study assessed utility brief assessment peabody picture vocabulary test edition ppvt proxy verbal viq large scale studies autism spectrum disorder asd sample proband asd ppvt correlations strong ppvt scores average points higher viq children ppvt scores within one standard deviation viq similarly classified abilities measures distributions ppvt viq novo mutation status highly similar results strongly support utility ppvt proxy viq large scale asd studies particularly genetic investigations
one key aspect synthetic biology development characterization modular biological building blocks assembled construct integrated cell based circuits performing computational functions likewise idea extracting biological modules cellular context led development vitro operating systems principle attracted substantial interest extend repertoire functional materials connecting modules derived synthetic biology respect synthetic biological switches sensors well biological targeting structure modules employed upgrade functions polymers solid inorganic material resulting systems hold great promise variety applications diagnosis tissue engineering drug delivery review reflects recent developments critically discusses challenges concerning vivo functionality tolerance must addressed allow future translation synthetic biology upgraded materials bench bedside elsevier rights reserved
soil erosion become serious problem recent decades due unhalted trends unsustainable land use practices assessment soil erosion prominent tool planning conservation soil water resource ecosystems universal soil loss equation usle applied nyabarongo river catchment drains total rwanda coverage small part southern uganda using geographic information systems gis remote sensing technologies estimated total annual actual soil loss approximately estimated million tons mean erosion rate cropland occupied total catchment presented mean erosion rate responsible total annual soil loss emergency soil erosion control required priority accorded cropland area extremely exposed actual soil erosion rate contributed total extreme soil loss catchment according study terracing cultivation method could reduce current erosion rate cropland areas therefore present study suggests catchment management constructing check dams terracing agroforestry reforestation highly exposed areas suitable measures erosion water pollution control within nyabarongo river catchment regions facing problems
significant high levels available waste tires brazil reached approximately thousand tons offer attractive potential use fuel advanced thermal conversion processes technologies energetic valorization waste tires reviewed two alternatives based updraft gasification modified reactor design proposed first large scale updraft gasifier igcc integrated gasification combined cycle considered gasification derived fuel waste tires capable produce electric energy per derived fuel waste tires fed reactor second alternative considered small scale updraft gasifier feeding internal combustion engine coupled electricity generator production electric energy per derived fuel waste tires fed reactor implementation technologies allow energetic valorization waste tires brazil solving disposal problems creating jobs reducing negative disposal environmental impacts landfills increasing distributed generation electricity
modern governments concerned population management pursue variety policies order deal demographic conditions adequately one countries seriously adopted population policies especially birth control policy late century iran different studies stress population growth policy first half population control policy late iran influenced predicament country found war iraq war well necessity population management renew human resources war perform development reconstruction plans properly war study claims adopting policies due full understanding real situations largely influenced meta forces political ideological discourses governed country fact governing discourses actually determine policies courses rather changes policy makers understanding real conditions society study indicates since islamic revolution different discourses including islamic idealism islamic pragmatism islamic realism principlism governed iran consequently different population policies consistent discourses followed words study tries show discursive attitudes seem account adequately population policies iran positivistic attitudes
considerable research examined association posttraumatic stress disorder ptsd symptoms social support one facet relationship deserves greater attention concerns trauma survivors negative expectations towards social support termed negative network orientation expand understanding negative network orientation current study examined shame possible mediator relationship ptsd symptoms negative network orientation sample female survivors intimate partner violence ipv additionally history child abuse evaluated moderator association shame negative network orientation model path analyses indicated significant indirect effect ptsd symptoms negative network orientation shame indicative mediation history moderated effect women history addition ipv showed significantly stronger relationship ptsd symptoms negative network orientation shame relative women history ipv findings support relevance shame understanding association ptsd symptoms negative beliefs social support highlight role childhood abuse moderator process among ipv survivors elsevier ltd rights reserved
purpose experimental modal analysis requires good knowledge various engineering fields mechanical vibrations transducers used vibration measurement transducers system calibration methods data acquisition systems digital signal processing system identification test facilities constitute key factor improving quality estimated modal model paper aims describe experimental facilities institute aeronautics space iae modal testing laboratory terms associated instrumentation data acquisition system metrological aspects computational resources discussion completed practical application showing ground vibration testing gvt unmanned aerial vehicle uav design methodology approach experimental facilities evaluated typical gvt using three shakers vertical horizontal excitations response measurement points global excitation method used excite desired modes reliability experimental modal model validated auto modal assurance criterion matrix measured modes structure findings experimental facilities successfully used validating dynamical characteristics uav testing originality value modal test facilities modal testing laboratory iae main research center brazilian air force described paper
background electroretinogram erg anomalies occur patients psychiatric disorders represent potential biomarkers diagnosis instance decreased rod erg wave amplitude vmax biological endophenotype young offspring high genetic risk schizophrenia bipolar disorder also decrease cone wave rod wave observed patients however biological underpinning anomalies remains unknown several genetic variants associated enhanced risk activate glycogen synthase kinase isozymes gsk alpha beta examined potential contribution gsk alpha beta modulation erg methods cone rod ergs recorded mice increased prpgsk beta mice reduced gsk beta mice gsk beta expression gska knockout mice results prpgsk eta mice observed decrease rod wave amplitude vmax whereas enhanced wave amplitude vmax found gsk beta mice increase cone wave amplitude vmax rod wave amplitude vmax observed gsk alpha mice conclusions gsk expression modulates erg parameters phenotype observed prpgsk beta mice consistent observations made hrs erg anomalies observed gsk beta gsk alpha mice confirm association rod cone wave amplitude expression gsk isozymes changes gsk expression activity may explain erg anomalies hrs patients thus supporting biological validity erg measurements valuable biomarker psychiatric research
fault detection problem control theory concerns monitoring system identify fault occurred two approaches distinguished signal processing based model based former concerns developing algorithms directly infer faults sensors readings latter uses simulation model real system analyze discrepancy sensors readings expected values simulation model contamination event detection systems edss water distribution systems followed signal processing based relies analyzing signals monitoring stations independently rather evaluating stations simultaneously within integrated network study show model based eds utilizes physically based water quality hydraulics simulation models outperform signal processing based eds also show model based eds facilitate development multi site eds mseds analyzes data monitoring stations simultaneously within integrated network advantage joint analysis mseds expressed increased detection accuracy higher true positive alarms fewer false alarms shorter detection time elsevier ltd rights reserved
study question age type hypogonadism namely hypothalamic primary gonadal defect become established men women prader willi syndrome pws summary answer type hypogonadism becomes established late adolescence early adulthood known already etiology hypogonadism pws heterogeneous clinical expression variable primary testicular failure common pws men combinations ovarian dysfunction gonadotrophin deficiency seen women study design size duration prospective study cohort pws patients followed mean duration years serial blood samples obtained assayed gonadotrophins inhibin anti mullerian hormone amh dehydroepiandrosterone sulfate dheas testosterone males estradiol females results compared normal reference values obtained literature purpose study defined following age groups infants years participants materials setting methods study participants males aged months years females aged month years genetically confirmed diagnoses pws deletions uniparental disomy imprinting center defect followed israel national multidisciplinary pws clinic main results role chance serum levels normal range miu adult men high fsh normal range miu elevated miu normal miu men testosterone low nmol compared normal range nmol reference population men years amh showed normal decrease age despite low testosterone levels inhibin normal infant boys low undetectable adult men hormonal profiles heterogeneous women men estradiol consistently detectable adult women inhibin low undetectable pws females although occasional samples showed levels within normal range vaginal bleeding reported occur first time eight women median age years years one regular monthly menses type hypogonadism primary secondary pws determined age years limitations reasons caution study cohort heterogeneous showing variability bmi cognitive disability medical treatment wider implications findings demonstration natural history reproductive hormone development pws suggests androgen replacement may indicated pws boys mid adolescence recommendations hormone replacement pws women need individually tailored serial measurements inhibin performed contraception considered women may potential fertility
theorists researchers noted overlap individuals bisexually identified queer identified although early definitions bisexuality may predominantly binary attracted women men recent years move toward queer understanding bisexuality attraction one gender beyond women men purpose study examine similarities differences adult women bisexually identified queer identified ages years sociodemographic characteristics two dimensions sexual orientation sexual behaviors attractions fluidity attractions sexual orientation identity identity centrality affirmation online sample mostly united states results indicated women bisexual queer similar terms sociodemographic characteristics exception education women identifying queer educated women identifying bisexual women identifying queer also likely women identifying bisexual report variability sexual behaviors attractions fluidity sexual orientation identity additionally women identifying queer reported higher levels identity centrality affirmation women identifying bisexual considerations sexual minority women health research discussed
extensive evidence perceived internally planned actions common representational basis action observation induce automatic tendency imitate others perceived executed action however based shared representations question arises distinguish self related related representations suggested control shared representations involves neural network centered temporo parietal junction tpj however specific role tpj controlling shared representations still clear conflict situation participants execute action observing action tpj might either facilitate relevant action inhibit irrelevant action mirror response present study used transcranial direct current stimulation tdcs condition neural activity right temporo parietal junction tpj analyzed corticospinal output indexed motor evoked potentials meps induced single pulse tms sptms left primary motor cortex action observation context conflict task results showed tdcs mediated increased control entail attenuation task irrelevant response activation effect motor mirroring suppressed reduced rather facilitating tpj activity via anodal tdcs selectively enhanced instructed motor plan self related representation outcome supports idea tpj plays critical role detecting mismatch self related related representations work enhance task relevant representations
large amounts coffee residues generated coffee processing plants ethiopia residues toxic possess serious environmental problems following direct discharge nearby water bodies cause serious environmental health problems study aimed quantify wet coffee processing waste estimate bio ethanol production study showed wastes potential environmental problems cause water pollution due high organic component acidic nature waste hydrolyzed dilute hso distilled water total sugar content sample determined titrimetrically refractometry maximum value obtained hydrolysis hso ethanol production monitored gas chromatography optimum yield ethanol obtained sample hydrolyzed hso hydrolysis temperature degrees fermentation initial based data concluded reuse main coffee industry wastes significant importance environmental economical view points conclusion study proposed utilize wet coffee processing waste produce bio ethanol provides alternative energy source waste biomass solves environmental waste disposal well human health problem
though advances medical treatment increased lifespans living hiv quality life concerns often remain treated health care providers integration mental health services within hiv medical setting provide comprehensive care patients including brief screening intervention appropriate follow study investigators examined mental health concerns identified behavioral health screens appointments infectious disease clinic compared previously published data setting assess changes patient reported problems results indicated shifts identified problems well demographic changes patient population previous study analyses suggested anger goal setting problems significantly contribute reports psychiatric symptoms suggested adjustment diagnosis depression sleep concerns significantly contribute likelihood engaging mental health consultation findings highlight importance behavioral health screening identify psychosocial concerns integrated hiv care settings
sibutramine may illicitly included herbal slimming foods supplements marketed natural enhance weight loss considering public health legal regulations urgent need effective rapid reliable techniques detect sibutramine dietetic herbal foods teas dietary supplements research comprehensively explored first time detection sibutramine green tea green coffee mixed herbal tea using atr ftir spectroscopic technique combined chemometrics hierarchical cluster analysis pca principle component analysis techniques employed spectral range classification discrimination euclidian distance ward algorithm unadulterated adulterated samples classified discriminated respect sibutramine contents perfect accuracy without false prediction results suggest existence active substance could successfully determined levels range totally green tea green coffee mixed herbal tea using ftir atr technique combined chemometrics elsevier ltd rights reserved
application nanocomposite pour point depressants improve rheology waxy crude oil novel efficient technique receives much attention however effects nano microparticles alone rheology waxy crude oil unclear paper monodispersed pmsq microspheres different sizes successfully synthesized two step solgel route effect pmsq microspheres flow behavior two typical waxy crude oils studied results showed pmsq microspheres disperse well oil phase single spheres small dosage pmsq microspheres significantly decreases gelation point elastic modulus viscous modulus apparent viscosity yield stress two oil samples indicating pmsq microspheres improve flow behavior waxy crude oil temperatures wax appearance temperature flow improving efficiency pmsq microspheres greatly influenced size dosage microspheres moreover adding pmsq microspheres oil samples also inhibits asphaltenes precipitation pmsq microspheres capable adsorbing part asphaltenes however pmsq microspheres little influence exothermic character microstructure two oil samples similar tests model waxy oil confirmed pmsq microspheres participate wax precipitation process change morphology precipitated wax crystals impede interactions precipitated wax crystals spacial hindrance effect inhibits development wax crystal network structure thus improves flow behavior oil mechanism brings new way improve flow behavior waxy crude oil favors development new generation flow improvers based nano microparticles elsevier ltd rights reserved
current rural medical information construction still imperfect large amount medical data related common rural disease used low utilization rate order improve utilization data provide help rural barefoot doctors rural residents developed distributed implied semantic text retrieval model improved weight calculation formula implied semantic text retrieval based implied semantic text retrieval distributed computing technology experiment results indicate retrieval framework shorten time text retrieval improve accuracy text retrieval
present new framework analysis visualization complex networks based structural information retrieved distance graphs matrices construction matrices graphs million edges requires massive breadth first search bfs computations facilitated using new software prepared distributed environments framework benefits data parallelism inherent pair shortest path problem extends cassovary open source memory graph processing engine enable multinode computation distance graphs related graph descriptors also introduce new type matrix constructed using clustering coefficient vertex invariant generated computational effort comparable one required previously known degree matrix delivering additional set information graph structure approach enables efficient generation expressive multidimensional descriptors useful graph embedding graph mining tasks experiments showed new framework scalable specific pair shortest path task provides better performance existing generic graph processing frameworks present developed tools helped analysis visualization real world graphs stanford large network dataset collection copyright john wiley sons ltd
alzheimer disease terminal age related neurological syndrome exhibiting progressive cognitive memory decline however patients addition exhibit ancillary neuropsychiatric symptoms npss include aggression communication provide recent evidence mis regulation small family genes expressed human hippocampus appear significantly involved expression patterns common aggression dna array mrna transcriptome based gene expression analysis candidate gene association genome wide association studies cgas gwas aggressive attributes humans revealed surprisingly small subset six brain genes also strongly associated altered gene expression patterns genes encoded five different chromosomes chr include androgen receptor chrxq brain derived neurotrophic factor bdnf chrp catechol methyl transferase comt chrq neuronal specific nitric oxide synthase nos chrq dopamine beta hydroxylase dbh chrq tryptophan hydroxylase tph chrp tph chrq interestingly expression three six genes comt dbh nos highly variable three six genes comt dbh tph involved serotonin metabolism biosynthesis neurotransmission iii five six genes bdnf comt dbh nos implicated development onset propagation schizophrenia magnitude expression genes implicated aggressive behavior appears pronounced later stages compared mci recent genetic data indicate extent cognitive impairment may bearing degree aggression accompanies phenotype
dramatic technology progress data manipulation induced several attempts baleful illegal processing regard several protection techniques including cryptography steganography watermarking used avoid illegal production distribution data online side attacks still major problem limits effectiveness watermarking techniques geometric attacks involve displacement pixels therefore induce synchronization errors original attacked image complicates watermark recovery process order solve synchronization problem propose use robust meshing technique different geometrical data image correct geometric distortion work propose novel geometrically invariant digital image watermarking approach based geometrical feature cover image defragmented delaunay triangulation respecting three constraints watermarking approaches imperceptibility embedded watermark embedding capacity robustness aim idea work propose blind imperceptible robust digital image watermarking scheme based defragmented delaunay tessellation weber law defragmented triangulation provides best synchronization embedded data attacks application weber law used propose auto thresholding algorithm compute optimal embedding gain factor watermark bit order ensure imperceptibility hidden data firstly invariant features host gray scale image extracted using canny edge detector delaunay tessellation saved keys points set generated defragmented select optimal robust triangles watermark embedding simulation results illustrate imperceptibility embedded data robustness proposed approach intentional unintentional geometrical attacks presented finally section copyright john wiley sons ltd
idiopathic pulmonary fibrosis ipf incurable debilitating disease impairs lung function eventually leads death currently lack effective modifying therapies treatments ipf underlying epidemiological mechanism clearly understood leads difficulty diagnosing managing ipf results high incurment disease associated cost even though ipf poses substantial economic burden lack research available cost triggers healthcare utilization barrier future economic evaluations new medicines ipf aimed conduct systematic literature review slr identify key cost generating events ipf gather related costing information data showed main events triggering high resource use patients symptoms ipf progression along comorbidities lung transplantations events result high economic impact use medications health care professionals hospital stays research needed identify direct indirect relationships ipf events costs generate would help evaluate area need future health technologies understand events targeted reduce global economic burden ipf
team consisting unknown number mobile agents starting different nodes unknown network possibly different times meet node agents anonymous identical execute deterministic algorithm move synchronous rounds along links network initial configuration agents called gatherable exists deterministic algorithm even dedicated particular configuration achieves meeting agents one node configurations gatherable gather deterministically algorithm give complete solution gathering problem arbitrary networks characterize gatherable configurations give two universal deterministic gathering algorithms algorithms gather gatherable configurations first algorithm works assumption common upper bound size network known agents case algorithm guarantees gathering detection existence round gatherable configuration agents node declare gathering accomplished upper bound size network known show universal algorithm gathering detection exist hence harder scenario construct second universal gathering algorithm guarantees gatherable configuration agents eventually get one node stop although tell gathering time first algorithm polynomial upper bound size network time second algorithm polynomial unknown size results important consequence leader election problem anonymous agents arbitrary graphs leader election fundamental symmetry breaking problem distributed computing goal assign common round value leader one entities value non leader others anonymous agents graphs leader election turns equivalent gathering detection hence product obtain complete solution leader election problem anonymous agents arbitrary graphs
background pseudoparalysis defined active forward flexion less degrees full passive motion controversy ideal surgical management massive rotator cuff tear pseudoparalysis purpose hypothesis purpose study prospectively analyze ability reverse pseudoparalysis arthroscopic rotator cuff repair arcr hypothesis absence substantial glenohumeral arthritis preoperative fatty infiltration grade higher acromiohumeral interval ahi less would prevent reversal pseudoparalysis arcr study design case series level evidence methods prospective multicenter study arcr performed preoperative pseudoparalysis conducted minimum follow year mean patient age years pseudoparalysis present mean months preoperatively preoperative radiographic evaluation included plain film evaluation ahi hamada classification mri evaluation fatty degeneration rotator cuff retraction functional outcome determined simple shoulder test sst american shoulder elbow surgeons ases shoulder score visual analog scale vas subjective shoulder value ssv results patients enrolled least year follow mean active forward flexion improved degrees preoperatively degrees postoperatively statistically significant improvements seen sst preoperatively postoperatively ssv ases shoulder score vas pseudoparalysis reversed patients difference rate reversal pseudoparalysis patients ahi less ahi pseudoparalysis reversed patients fatty degeneration grade higher rotator cuff muscles conclusion arcr lead reversal preoperative pseudoparalysis patients minimal preoperative glenohumeral arthritis arcr viable first line treatment patients pseudoparalysis absence advanced glenohumeral arthritis
purpose paper highlight use induced affect collaborative therapeutic assessment components cognitive affective stress management training casmt technique rehearsing cognitive physical relaxation coping skills conditions high affective arousal shown result high levels coping self efficacy provides diary based feedback clients processes underlying stress experiences helps identify affect arousing experiences targeted include descriptions technique online stress coping daily diary well sample transcripts illustrating integrated casmt evokes high affective arousal skills rehearsal illustrate idiographic assessment also describe three treatment cases involving female clients ages anxiety symptoms participated weeks casmt reported daily stress coping experiences following intervention total weeks resulting time series data analyzed using simulation modeling analysis sma revealed clients reported improved negative affect regulation course treatment yet exhibited idiographic patterns change outcome coping skills variables results illustrate may used enhance emotional self regulation time series analyses identify idiographic aspects treatment response would evident group data
well established mammals prenatal exposure exogenous testosterone masculinizing effect female morphology behavior fewer studies however conducted males subject results controversial present study investigated long term effect administering extra prenatal testosterone testosterone proprionate adult male domestic rabbits morphology behavior using two different control groups non treated vehicle injected mothers unexpectedly administering vehicle alone clear masculinizing effect morphological behavioral measures lower body mass smaller anogenital distance smaller chin glands lower chin marking activity greater timidity administration counteracted effect dose dependent manner animals exposed highest dose prenatally showed values morphological behavioral measures equivalent greater non treated control group conclude additional testosterone beyond male fetuses produce utero result increased masculinization thus male fetuses less susceptible prenatally hormonal effects females presumably stress related effects administering vehicle alone resulted masculinization could recovered prenatal administration results may partly account contradictory findings previous studies indicate importance including non treated sham vehicle treated controls future experiments elsevier rights reserved
research shown false memory production enhanced material emotionally congruent mood participant time encoding far research conducted examine influence generic negative affective mood states generic negative stimuli false memory production addition much research limited focuses valence arousal dimensions fails take account comprehensive nature emotions current study demonstrates effect goes beyond general negative positive moods acts discrete emotional level participants underwent standard emotion induction procedure listening negative emotional neutral associative word lists emotions induced negative word lists associated nonpresented critical lures related either fear anger negative valence emotions also high arousal results showed valence arousal controlled false memories likely produced discrete emotionally congruent compared incongruent materials results support spreading activation theories false remembering add understanding adaptive nature false memory production
background myocardial microvascular loss myocardial infarction remains therapeutic challenge autologous stem cell therapy considered alternative however shown modest benefits due impairing effects cardiovascular risk factors stem cells allogenic adipose derived stem cells ascs may overcome limitations low immunogenicity paracrine potential may good candidates cell therapy present study investigated effects allogenic ascs released products cardiac rarefaction post methods pig subcutaneous adipose tissue ascs isolated expanded gfp labeled asc angiogenic function assessed vivo chick chorioallantoic membrane cam model pigs underwent induction days randomized receive allogenic ascs intracoronary infusion conditioned media intravenous infusion ascs pbs placebo control cardiac damage function monitored cardiac magnetic resonance imaging upon infusion baseline cmr weeks thereafter assessed myocardium microvessel density angiogenic markers vegfr vegfr vwf enos collagen deposition reparative fibrosis tgfa tarii collagen differential proteomics ascs performed characterize asc protein signature results cam indicated significant asc proangiogenic capacity pigs pbs placebo animals displayed impaired cardiac function weeks infusion baseline administration ascs significantly enhanced neovessel formation favored cardiac repair post groups molecular markers angiogenesis significantly upregulated transcriptional protein levels silico bioinformatics analysis asc proteome interactome indicated activation coordinated protein network involved formation microvessels resolution rarefaction conclusion coadministration allogenic ascs synergistically contribute neovascularization infarcted myocardium coordinated upregulation proangiogenic protein interactome
focus article cluster grassroots movements networks networks association indonesian migrant workers atki based hong kong using kelly filipino migration transnationalism class identity ari working papers series singapore asia research institute typology four dimensions class position process performance politics framework analysis article shows indonesian migrant domestic workers hold multiple class identities various positions transnational political space organising particular spaces indonesian migrant domestic workers express agency reformulate gender roles identify transnational social class social class identification based awareness transnational nature exploitation migrants experience also framed within wider global perspective root causes neoliberal policies unjust trade agreements accepting class position ascribed domestic workers migrant organisations chose define social class performance generate political capital article adds notion positionality intersectionality approach way social class intersects gender economic status occupation ethnicity transnational status might differ depending position
fodmap fermentable oligo mono saccharides polyols heterogeneous group highly fermentable poorly absorbed short chain carbohydrates polyols dietary fodmaps might exacerbate intestinal symptoms increasing small intestinal water volume colonic gas production intestinal motility recent years low fodmap diet treatment irritable bowel syndrome ibs gained increasing popularity present review aim summarize physiological clinical nutritional issues suggesting caution prolonged use dietary treatment basis existing literature criteria inclusion fodmaps list fully defined although low fodmap diet positive impact symptoms ibs particularly bloating diarrhea quality evidence lower optimal due frequent methodological flaws particularly lack proper control group lack blinding particular remains proven whether regimen superior conventional ibs diets drastic reduction fodmap intake physiological consequences intestinal microbiome colonocyte metabolism still poorly understood low fodmap diet imposes important restriction dietary choices due elimination staple foods wheat derivatives lactose containing dairy products many vegetables pulses several types fruits reason patients may risk reduced intake fiber calcium iron zinc folate vitamins natural antioxidants nutritional risk low fodmap diet may higher persons limited access expensive alternative dietary items included low fodmap diet
low serum testosterone common increasingly prevalent increased age recent studies report epidemic prescribing concern unnecessary treatment investigated number men tested prevalence low serum levels initiation treatment among low levels men treated veterans affairs facilities northwest visn identified male veterans aged years examined yearly proportions men tested found low levels total free bioavailable subsequently treated excluded men treatment year prior men diagnoses prostate breast cancer treatment initiation defined first prescription within year following low test yearly population eligible men visn increased proportion men serum tests increased among tested men percentage men low levels increased however proportion men low levels given treatment within year decreased despite large increases testing detection men low levels slight decrease proportion men low levels treated decrease treatment time period contrasts studies may related higher comorbidity veterans formulary restrictions use transdermal formulations
whenever intrusion happens privacy security system compromised order detect different types attacks happen network intrusion detection system ids plays crucial role network security ids designed order classify activities system abnormal normal machine learning based intrusion detection gaining attention recent years able give better results greater accuracy high detection rate novel attacks paper performance different kernels support vector machine svm evaluated knowledge discovery databases cup kdd data set detection accuracy detection time compared detection time reduced adopting principal component analysis pca curtails higher dimensional dataset lower dimensional dataset experiments conducted research shows gaussian radial basis function kernel svm higher detection accuracy
background quest achieve early hiv treatment goals national hiv treatment programmes dependent international funding dramatically redesigned last years bottlenecks treatment provision conceived health system problems addressed via structural logistical fixes routine hiv testing point care equipment nurse led antiretroviral treatment initiation patient tracking patient perspectives rarely taken account fixes considered patients therapeutic experiences often remain periphery planning stage considered within context monitoring evaluation audits programmes running methods ethnographic research conducted five clinics swaziland participatory approaches used collect data first author trained hiv counsellor order collect observational data continuum care conducted depth interviews interlocutors involved different phases results although recently adopted global hiv strategies proven effective scaling treatment swaziland research demonstrates effort expand services rapidly meet donor targets also undermined patients therapeutic experiences overtaxed health workers counterproductive ultimate goal treatment scale article provides perspective beyond structural elements impede universal treatment explores patient views experiences strategies adopted support treatment expansion particular focus shifting key care logistical tasks expert clients conclusion argue quest achieve universal early access treatment donors states must beyond strengthening health systems strive enhance quality patient experiences take seriously health worker limitations
exogenous cortisol administration used test influence glucocorticoids variety outcomes including memory affect careful control factors known influence cortisol endogenous hormone levels central success research use hormonal birth control hbc known exert many physiological effects including decreasing salivary cortisol response stress unknown hbc influences circulating cortisol levels exogenous cortisol administration determine effects examined role hbc participants cortisol levels receiving synthetic cortisol hydrocortisone two separate studies study healthy women taking hbc healthy men administered body weight intravenous dose hydrocortisone plasma cortisol levels measured study participants women hbc received hydrocortisone pill salivary cortisol levels measured taken together results studies suggest hbc use associated greater cortisol increase following cortisol administration data important methodological implications given controlled dose hydrocortisone cortisol levels may increase dramatically women taking hbc versus women hbc men studies manipulating cortisol levels women hormonal contraceptives investigated separate group
evolution long water waves small amplitude surface waves weak nonlinearity weak dispersion weak perturbation fluid mechanics three spatial dimensions described generalized dimensional variable coefficient kadomtsev petviashvili equation studied paper symbolic computation via truncated painleve expansion auto backlund transformation derived based certain variable coefficient constraints one soliton two soliton homoclinic breather wave rouge wave solutions respectively obtained via rota method graphic analysis shows soliton propagates varying soliton direction change value one equation cause change soliton shape soliton amplitude affected change represents dispersion respectively stand disturbed wave velocities along directions perturbed effects scaled spatial coordinates temporal coordinate soliton direction type interaction two solitons vary change value affected homoclinic breather wave rouge wave respectively displayed rouge wave comes extreme behaviour homoclinic breather wave elsevier ltd rights reserved
efficient procedure calculating electromagnetic fields multilayered cylindrical structures reported paper using symbolic computation spectral green functions suitable numerical implementations determined compact closed forms applications presented structures two dielectric layers
idiopathic pulmonary fibrosis ipf chronic progressive disease increasing prevalence marked poor prognosis limited treatment options activated potassium channels shown play key role aberrant activation responses injury epithelial cells fibroblasts considered key drivers fibrotic process ipf pharmacological inhibition ipf derived fibroblasts able somewhat prevent tgf beta basic fibroblast growth factor dependent profibrotic responses current study investigated whether blockade ion channel vivo selective inhibitor senicapoc able attenuate histological physiological outcomes early fibrosis large animal sheep model pulmonary fibrosis also determined whether treatment targeting profibrotic activity sheep lung fibroblasts senicapoc administered established fibrosis weeks bleomycin instillation drug efficacy assessed weeks treatment treatment senicapoc improved pre established bleomycin induced changes compared vehicle control leading improved lung compliance reduced extracellular matrix collagen deposition reduction alpha smooth muscle actin expression proliferating cells vivo vitro studies show inhibiting kca ion channel able attenuate early fibrogenic phase bleomycin dependent fibrosis inhibits profibrotic behavior primary sheep lung fibroblasts supports previous research conducted human ipf derived fibroblasts suggests inhibiting signaling may provide novel therapeutic approach ipf
immunomodulatory effects vitamin extensively studied context autoimmunity multiple studies demonstrated high prevalence vitamin deficiency autoimmune diseases recently possible protective role vitamin autoimmunity described however function remains controversial studies investigated role vitamin patients sjogren syndrome review compiled main features pathogenesis vitamin immunomodulatory effects possible interaction data suggests vitamin may play role pathogenesis addition vitamin low levels found patients associated extra glandular manifestations lymphoma neuropathy suggesting possible benefit effect vitamin elsevier rights reserved
paper hypothetical district representing typical urban districts hong kong considered district cooling system model designed district mathematical models tailor designed major district cooling system equipment simulate effects changing pumping station configuration energy performance district cooling system measures included use multiple pumping stations unequal number pumps station view vast number pumping station combinations possible analysis hydraulic gradient evaluation method adopted assist quick assessment exploration combinations would technically feasible furthermore energy performance technically feasible combinations evaluated identify optimum design would lead lowest electricity consumption practical application district cooling system one main pumping station distributing chilled water buildings district chilled water flow rate pressure head high adding booster pumping stations help reduce pressure head pump size hence power demand main pumping station paper effects different pumping station configurations energy performance district cooling system investigated configuration could mitigate impacts low delta energy performance district cooling system also identified
background objective primary progressive aphasia ppa clinical syndrome due different neurodegenerative conditions accurate early diagnosis needs supported reliable diagnostic tool individual level study investigated ppa fdg pet brain metabolic patterns single subject level order assess case case variability relationship clinical neuropsychological findings material methods patients semantic variant ppa non fluent variant nfv ppa logopenic variant ppa slowly progressive anarthria spa mixed ppa ppa included clinical neuropsychological information fdg pet data acquired baseline follow months evaluated clinical progression brain metabolism analyzed using optimized validated voxel based spm method single subject level results fdg pet voxel wise metabolic assessment revealed specific metabolic signatures characterizing ppa variant individual level reflecting underlying neurodegeneration language networks notably additional dysfunctional patterns predicted clinical progression specific dementia conditions case nfv ppa metabolic pattern characterized involvement parietal subcortical brainstem structures predicted progression corticobasal degeneration syndrome progressive supranuclear palsy ppa ppa cases progressed alzheimer disease frontotemporal dementia follow presented extended bilateral patterns baseline discussion results indicate fdg pet voxel wise imaging valid biomarker early differential diagnosis ppas prediction progression specific dementia condition study supports use fdg pet imaging quantitative assessment clinical settings better characterization ppa individuals prognostic definition possible endo phenotypes
damage identification problem involves detection localization assessment extent damage structure remaining life could predicted visual nondestructive experimental damage detection methods ultrasonic acoustic emission ones based local evaluation easily accessible areas therefore require certain prior knowledge damage distribution purpose providing global damage detection methods applicable complex structures techniques based modal testing signal processing constitute promising approach damage identification methods examine changes dynamic characteristics structure natural frequencies mode shapes detect structural damage modal parameters including natural frequencies mode shapes damping ratios known essential parameters analyzing dynamic behavior structure paper deals identification modal parameters structures using two step algorithm proposed method free vibration response structure decomposed using wavelet packet transform decomposed signal energy main signal used modal parameter identification using peak picking method performance proposed method verified results experimental benchmark problem
transgenic mice carrying mutations cause autism spectrum disorders asds continue valuable determining molecular underpinnings disorders recently researchers taken advantage models combined cre loxp similar systems manipulate gene expression space time thus clearer picture starting emerge cell types circuits brain regions developmental time periods underlying asds asd causing mutations restricted rescued specifically excitatory inhibitory neurons different neurotransmitter systems cells specific forebrain cerebellum addition mutations induced corrected adult mice providing evidence plasticity reversibility core asd symptoms limited availability cre lines highly specific certain cell types time periods provides challenge determining cellular circuitry bases autism technological advances may eventually overcome obstacle
objectives theoretical basis believing healthy lifestyle interventions improve mental well evidence show mental well protective future health study contributes evidence base examining changes mental well associated one body one life obol healthy lifestyle programme community setting west midlands study design quantitative evaluation methods conducted study lifestyle intervention obol multi component intervention includes exercise healthy eating education mental wellbeing measured warwickeedinburgh mental well scale physical activity fruit vegetable consumption self reported measures collected week intervention three months post completion nonparametric tests used assess differences groups linear mixed models used assess change time results four hundred eighty one attendees adult participants completed valid warwickeedinburgh mental well scale starting obol completed warwickeedinburgh mental well scale immediately post intervention three months mental well levels increased significantly course intervention sustained three month follow baseline median warwickeedinburgh mental well scale score interquartile range completion interquartile range month follow interquartile range change mental well clinically significant accounting age gender changes fruit vegetable consumption physical activity appeared explain variation mental well conclusion found significant improvements mental well among participants directly intervention sustained three month follow findings contribute growing body knowledge contribution lifestyle interventions promoting sustaining mental well authors published elsevier ltd behalf royal society public health
emotional processing complex cognitive function necessary successfully adjust social environments need interpret respond cues convey threat reward signals combatants consistently shown atypical well poor social interactions available reintegration programs aim facilitate adaptation combatants communities however incorporate actions improve enhance cognitive emotional regulation present study aimed evaluating usefulness intervention focused social cognitive training sct designed equip combatants enrolled social reintegration route social cognition skills group combatants mean age men colombian illegal armed groups recruited study invited take part sct continued conventional reintegration intervention groups underwent training sessions period weeks assessed comprehensive protocol included psychosocial behavioral emotion processing instruments scores instruments prior intervention compared within groups groups matched baseline combatants receiving sct experienced significant improvements reduction aggressive attitudes effects observed continuing conventional reintegration intervention first study achieves outcomes population using sct intervention discuss implications results toward better social reintegration strategies
purpose based previous investigations vascular blood supply femoral head technique anatomical reduction slipped capital femoral epiphysis developed technique modification original technique dunn using retinacular soft tissue flap allows visual control epiphyseal vascular blood supply report experience inventor institution critical discussion available literature methods using trochanteric osteotomy surgical dislocation hip retinacular soft tissue flap created containing deep branch medial femoral circumflex artery external rotators capsule femoral epiphysis mobilised safely reduced femoral neck resection almost constantly present reactive metaphyseal callus results institution rate avascular necrosis comparably low dunn original results present cases bleeding already evident reduction epiphysis ten year long term results favorable cases good functional result little progression osteoarthritis however authors reported higher rates avascular necrosis initial experience conclusions experienced hands using correct meticulous surgical technique results favorable regarding rates avascular necrosis functional outcome development radiographic osteoarthritis even acute severe cases avascular necrosis rare observed evidence intra operative femoral head perfusion reduction epiphysis
healthy sleep habits include sufficient sleep regular bedtimes established sleep routines responsibilities paid unpaid work arise daytime assumed haunt night well eventually affecting sleep habits long term comparison sleep duration time diary data shows sleep duration declined large extent generally assumed moreover analyses timing sleep sleep routines using time diary data also show much evidence assumed decline contrary increasing work family responsibilities positively affect regular bedtimes sleep routines
selection facilities replaced building retrofit challenging due conflicting interests budget constraints building minimum requirements human comfort environmental goals order assist decision makers appropriate selection facilities paper presents multi objective optimization model aiming optimizing retrofitting costs energy savings water savings payback period points earned leadership energy environmental design leed rating system work introduces green building certification objective existing building retrofits benefits existing building retrofit green building certification building owner includes reduced operating costs carbon footprint improved air quality developed model considers wide range facilities saving measures retrofitting options energy water efficiency credit categories leed case study hotel south africa presented demonstrate feasibility proposed model optimization approach elsevier rights reserved
growing incidence rate breast cancer coupled cellular chemotherapeutic resistance made disease one prevalent cancers among women worldwide despite recent efforts understand underlying cause resistance due mutation feasible tactics overcome bottleneck issue could addressed concept polypharmacology disguising drugs present pharmacopeia novel purposes drug repurposing note proposed multi modal computational drug repositioning stratagem predict drugs possessing anti proliferative effect results suggest ombitasvir hepatitis nsb polymerase inhibitor could repurposed control prevention beta tubulin driven breast cancers wiley periodicals inc
parkinson disease neurodegenerative disease characterized selective degeneration dopaminergic neurons substantia nigra parkin encoded park ubiquitin ligase frequently mutated gene casually linked autosomal recessive early onset familial tested effect park ethanol induced dopaminergic neurodegeneration park knockout transgenic mice chronic ethanol feeding male park wild type mice weeks old fed lieber decarli diet containing ethanol weeks compared responses found knockout park exacerbates ethanol induced behavioral impairment well dopamine depletion mechanism study found knockout park increased reactive oxygen species ros production mitophagy formation mitochondrial dysfunction expression pro apoptotic proteins decreased expression pro autophagic proteins knockout park also increased ethanol induced activation mitogen activated protein kinase addition ros production mitophagy formation mitochondrial dysfunction expression pro apoptotic proteins increased expression pro autophagic proteins decreased treatment ethanol park sirna transfacted cells moreover exacerbating effects park deletion ethanol induced ros generation mitophagy mitochondrial dysfunction well cell death reduced specific inhibitor vitro vivo park deficiency exacerbates ethanol induced dopaminergic neuron damage kinase dependent inhibition autophagy mitochondrial function
objectives first aim study compare characteristics comorbidities patients eating disorders suffered childhood abuse second aim analyze differences outcome psychodynamic therapy abused abused patients methods twenty six adolescent patients eating disorders assessed adolescent evaluated single expert psychiatrist checklists questionnaires edi scl bis dissociative experiences scale global assessment functioning scid ctq self control according results ctq cut patients divided two groups experienced history abuse underwent psychodynamic psychotherapy assessed months results eleven patients history abuse according ctq score significant differences found abused abused patients demographic clinical comorbid characteristics sex age type eating disorder comorbid impulse control personality addictive disorders abused patients showed significantly higher score many scale psychotherapeutic intervention patients history abuse resulted significant decrease symptom checklist scl psychoticism dimension whereas patients history abuse significant decrease found scl somatization obsessive compulsive phobic anxiety dimensions scl global severity index eating disorder inventory interceptive deficits dissociative experience scale conclusion regarding first aim study proved history abuse significantly related patient comorbidities regarding second aim history abuse related patient improvement psychotic symptoms whereas patients experienced abuse improved variety symptoms thus abuse history considered negative prognostic factor patients eating disorders undergoing dynamic psychotherapy however psychotherapy may role preventing early psychotic disorders patients without history abuse
objective characterize relation established previously unexplored characteristics fertile life cause cause specific mortality design prospective cohort study setting applicable patient total postmenopausal women intervention women fertile lifespan age menarche menopause number children maternal age first last child maternal lifespan interval maternal age first last child postmaternal fertile lifespan interval age last child menopause lifetime cumulative number menstrual cycles unopposed cumulative endogenous estrogen exposure main outcome measure registry based cause cause specific mortality result total women died years follow compared women children higher hazard dying found women child hazard ratio confidence interval became nonsignificant models adjusted confounders late age first last birth associated lower hazard dying longer maternal postmaternal fertile lifespan longer fertile lifespan unopposed cumulative exposure significantly harmful cause mortality findings differed regard direction size statistical significance stratifying cardiovascular disease cancer mortality conclusion overall found late first last reproduction protective cause mortality whereas longer maternal lifespan postmaternal fertile lifespan exposure harmful cause mortality research needed contemporary cohorts larger sample sizes extreme ages birth american society reproductive medicine
background currently college campuses across way address campus cigarette smoking mainly policies restrict smoking campus premises however well understood whether college level anti smoking policies help reduce cigarette smoking among students addition little known policies may impact student smoking behavior study attempted address issues literature review methods systematic literature review performed identify relevant studies following online databases searched using specific keywords ovid medline psycinfo pubmed google scholar studies met exclusion inclusion criteria selected review studies excluded based type anti smoking policy studied results total studies included review majority studies cross sectional design longitudinal rest involved counting cigarette butts smokers studies represented women men whites individuals ethnic racial groups majority studies evaluated smoke free tobacco free campus policies types policies studied included use partial smoking restriction integration preventive education smoking cessation programs college level policies far role campus smoking policies reducing student smoking behavior concerned results cross sectional studies mixed however results two longitudinal studies reviewed promising policies found significantly reduce smoking behavior pro smoking attitudes time conclusion longitudinal studies needed better understand role college anti smoking policies student smoking behavior current data indicate stricter comprehensive policies policies incorporate prevention cessation programming produce better results terms reducing smoking behavior
associations social class prosocial behaviordefined broadly action intended help othersmay vary function contextual factors three studies examined making prosocial actions public versus private moderates association study participation public prosocial campaign higher among upper lower class individuals studies lower class individuals prosocial dictator game scenario private public whereas upper class individuals showed reverse pattern follow analyses revealed importance reputational concerns shaping class differences prosociality specifically higher class individuals reported pride motivated prosocial behavior lower class individuals association partially accounted class based differences prosociality public versus private contexts together results suggest unique strategies connecting relating others develop based one position class hierarchy
ankylosing spondylitis prototype rheumatoid factor negative spondyloarthropathy causes vertebrae fuse making spine less flexible resulting hunched forward posture year old male known case ankylosing spondylitis presented left quadriceps rupture raising right foot lightly hit football fitted knee immobilizer emergency measure extent rupture yet established patient requested leave home right quadriceps ruptured well took immobilizer bathroom report herein extremely rare case ankylosing spondylitis atrophy quadriceps extent causing pathological muscle rupture prolonged period immobilization results muscle wasting leads knee joint instability muscle repaired soon possible
allergies animals multifactorial complex diseases symptoms vary highly species well different types allergic disorders pathogenesis far known similar humans contrast deep knowledge human allergology veterinary field lags far behind however rising field interest comparative veterinary allergology humans big data available central databases accessible animal allergies biggest limitation veterinary field big cohort studies published allowing conclusions impact gender breed regional differences disease another aspect noted sterilization surgery pet animals regularly done dogs cats well male horses may explain isless impact sexual hormones allergies impact difficult analyze review article interesting findings regarding gender aspects companion animals extracted current literature could potential interest animal owners well allergic patients interested human animal comparisons summarize however still lack studies investigating gender predisposition allergies cats dogs horses
background increased clinical political attention towards integrating general psychiatric emergency departments however research psychiatric service users experiences regarding general eds limited aim identify summarize current qualitative evidence regarding service users experiences attending eds secondary aim apply test newly developed cerqual approach summarizing qualitative review findings methods systematic literature review five databases based prisma guidelines yielded unique entries screening title abstract identified studies full text assessment nine studies included included studies critically appraised using casp thematic synthesis applied data extraction identification findings cerqual approach utilized assess confidence findings results results review showed moderate confidence findings service users experience meeting caring judgmental staff waiting times stressful environment integral experiences contrast low low confidence seen findings service users experience symptoms ignored eds used due lack alternatives companion may improve service users experience outcome visits conclusion service users experience stress discomfort service users highly appreciate knowing staff ease discomfort overall results review speak favour integrated eds service users needs likely recognized accommodated
article considers date problems parallel computing systems development russia study describes engineering interface organization high performance system programmable structure partition specific subsystems focused applied tasks solution based concept homogeneous computing systems hcs relying model collective calculators hcs concept formulated institute mathematics ussr leadership evreinov approach particularly relevant terms growing popularity information networks combining numerous personal computers pcs obviously necessary develop software tools integrate disparate calculators system identify required number sub systems specific problem solving interference hardware software parts calculators must avoided software development process programmable structure computer system provided stage unification calculators software subsystem interface called agent dcs experience development interface organization distributed computing systems programmable structure allocation subsystems specific applications software described present document tested experimental organization dcs department computer engineering nstu
epileptiform discharges isolated cortex explored using neural field theory neural field model isolated cortex used consists three neural populations excitatory inhibitory excitatory bursting mechanisms isolated cortex gives rise seizure like waveforms thought underly pathological eeg waveforms deafferented cortex explored shown model reproduces similar time series oscillatory frequencies paroxysmal discharges compared physiological recordings acute chronic deafferentation states furthermore within model ictal activity arises perturbations steady states close dynamical system instability boundary hence distinct corticothalamic seizures observed model intact brain involved limit cycle dynamics results applied experiments deafferented cats
aim service review secondary care advanced nurse practitioner led service background acute hospital based elderly care rehabilitation service evolved year period traditional consultant junior doctor configuration consultant advanced nurse practitioner configuration review evaluated advanced nurse practitioner team role clinical setting constraints experienced result traditions hospital organization evaluation review drew conclusions opinion data collected professionals non professionals within rehabilitation service key issues organizational infrastructure traditions impact service delivery advanced nurse practitioner team demand senior management act developmental constraints conclusions advanced nurse practitioner led rehabilitation service fit purpose emerging model non medical led care however important organizational constraints identified implications nursing management advanced nurse practitioner team working collaboration medical consultants model future service redesign acute hospital setting nevertheless presented challenges senior health care managers current organizational infrastructures
background sexual risk behavior primary vector hiv transmission among substance users united states gender crucial moderator risk behavior objectives purpose study examine gender differences factors age race ethnicity education predict main partner unprotected sexual occasions uso using unique platform two parallel nida national drug abuse treatment clinical trials network gender specific safer sex intervention trials methods baseline assessments male female participants included demographic characteristics past month sexual activity diagnostic assessment alcohol cocaine stimulant opioid use disorders using mixed effects generalized linear modeling main outcome uso two way interactions gender age race ethnicity education evaluated adjusted alcohol cocaine stimulant opioid use disorder results adjusted alcohol use disorder interaction education gender significant men high school greater education significantly associated uso compared men less high school women greater high school education significantly associated less uso compared women high school education none interactions significant adjusted cocaine stimulant opioid use disorder conclusions importance study demonstrates gender differences relationship education alcohol use disorder main partner uso individuals substance abuse treatment underscores importance considering demographic substance use factors hiv sexual risk behavior crafting prevention messages population
paper introduce algorithmic procedure computes abelian subalgebras ideals given finite dimensional malcev algebra computations performed using non zero brackets law algebra input additionally algorithm also computes invariants algebras supporting output list abelian ideals subalgebras maximal dimension returned implement algorithm used symbolic computation package maple performing brief computational statistical study implementation copyright john wiley sons ltd
article discuss implementation polyphase filter real time data processing radio astronomy polyphase filter standard tool digital signal processing well established algorithm describe detail implementation polyphase filter algorithm behaviour three generations nvidia gpu cards fermi kepler maxwell intel xeon cpu xeon phi knights corner platforms implementations aim exploit potential data reuse algorithm offers gpu implementations explore two different methods achieving first makes use texture cache second uses shared memory discuss usability implementations along behaviours measure performance execution time critical factor real time systems also present results terms bandwidth compute gflop type conversions gtc include presentation results terms sample rate processed real time chosen platform intuitively describes expected performance signal processing setting findings show gpus considered performance polyphase filter using lower precision input data limited type conversions rather device bandwidth compare results implementation xeon phi show xeon phi implementation performance greater cpu implementation however insufficient compete performance gpus conclude comparison best performing code two implementations polyphase filter showing implementation faster nearly cases work forms part astro accelerate project many core accelerated real time data processing library digital signal processing time domain radio astronomy data elsevier rights reserved
last years geometric algebra euclidean homogeneous conformal models attracts research interest many areas computer science engineering particularly computer graphics shown produce efficient smooth results algebras paper present inclusive algorithm real time animation interpolation gpu based geometric skinning animated deformable virtual characters using conformal model geometric algebra cga compare method standard quaternions linear algebra matrices dual quaternions blending skinning algorithms illustrate cga gpu inclusive skinning algorithm provide smooth efficient results state art previous methods furthermore elements cga handle transformations cga motors support translation rotation dilation uniform scaling joints single gpu supported mathematical framework avoid conversion different mathematical representations contrast quaternions dual quaternions support rotation rotation translation respectively hence main novelty replacement different types algebras conversions cpu gpu linear algebra matrices quaternions dual quaternions euler angles animation interpolation skinning single mathematical representation cga motors optimally handle composition translation rotation scaling joint transformations interpolations employing latest cga code generators provide sample implementation algorithm running natively vertex shader program modern gpus typical deformable virtual character simulations
background smd amino acid peptide smd major epitope smith antigen specific adult systemic lupus erythematosus sle anti smd antibody exhibited higher sensitivity specificity anti antibody diagnosing adult sle however utility anti smd antibodies remains unclear children sle csle study aimed assess characteristics anti smd antibody diagnosis csle methods samples children different rheumatological immunological disorders including autoimmune diseases sle ankylosing spondylitis nonautoimmune diseases henoch schonlein purpura hsp idiopathic thrombocytopenia purpura hematuria arthralgia collected shanghai children medical center march february seventy age sex matched patients enrolled study negative controls patients sera analyzed anti smd anti anti nrnp anti double stranded dna dsdna anti nucleosome anti ssa anti ssa anti ssb anti scl anti histone antibodies using immunoblotting assay differences sensitivity specificity anti smd anti antibodies compared chi square test correlations anti smd auto antibodies analyzed using spearman correlation analysis value considered statistically significant results thirty six patients csle found positive anti smd patients csle cohort found positive anti compared csle shown anti smd detected patients patients hsp comparison anti demonstrated anti smd higher sensitivity chi lower specificity chi diagnosis csle analysis revealed anti smd antibodies positively correlated anti dsdna anti nucleosome anti histone antibodies csle moreover clearly shown anti smd sensitive anti discriminating autoimmune diseases nonautoimmune disorders patients arthralgia hematuria conclusions measurement anti smd patients csle higher sensitivity marginally lower specificity anti suggested inclusion anti smd testing integrated laboratory diagnosis csle may significantly improve overall sensitivity child populations
precision medicine concept utilizing modern molecular diagnostics effective therapy accurately applied cancer patient improve survival rates treatment triple negative breast cancer tnbc remains challenging issue aim study compare molecular subtypes triple negative breast cancer tnbc taiwanese non asian women geo datasets non asian groups taiwanese groups breast cancer including tnbc acquired normalized cluster analyzed using tnbc cell lines different subtypes namely mda basal like mda mesenchymal stem like msl mesenchymal mda luminal androgen receptor lar immunomodulatory real time pcr triplicate genes signatures performed validate specificity subtypes results showed percentage tnbc subtypes non asian women namely msl lar respectively data taiwanese normalized clustered five tnbc subtypes namely msl lar classified real time pcr validated specificity subtypes besides presence interaction msl subtypes suggests involvement tumor microenvironment tnbc subtype classification data suggested exist different presentations non asian taiwanese tnbc subtypes provides important information selection therapeutic targets designs clinical trials tnbc patients
killer cell immunoglobulin like receptors kirs modulate disease progression pathogens including hiv malaria hepatitis cynomolgus rhesus macaques widely used nonhuman primate models study human pathogens considerable effort put characterizing kir genetics however previous studies relied cdna cloning sanger sequencing lack throughput current sequencing platforms study present high throughput full length allele discovery method utilizing pacific biosciences circular consensus sequencing ccs also describe new approach macaque exome sequencing mes development rhexome adapted target capture reagent includes macaque specific capture probe sets using sequence reads generated whole genome sequencing wgs mes inform primer design able increase sensitivity kir allele discovery demonstrate increased sensitivity defining nine novel alleles within cohort mauritian cynomolgus macaques mcm geographically isolated population restricted kir genetics thought completely characterized finally describe approach genotyping kirs directly sequence reads generated using wgs mes reads findings presented expand understanding kir genetics mcm associating new genes eight kir haplotypes demonstrating existence least one kirds gene associated every haplotype
paper main aspects construction low power cmos pipelined analog digital converters adcs discussed main requirements bit redundant stage pipeline adc defined examples digital analog error correction mechanisms pipelined adc conjunction power reduction mechanisms considered
clean renewable energy wind power gets rapid growth recent years increasing proportion wind power generation fluctuation intermittency wind energy impedes safe stable operation national power grids causes wind curtailment energy waste hindering development wind power industry china solve problem wind heating conversion proposed however long distance transmission wind fields residential areas thermal energy urgent issue wind heating paper presents novel wind heating conversion long distance transmission system simple device utilized wind heating conversion present system thermal energy transported heat demand site latent heat transmission working fluids model novel system built thermodynamics analysis showed maximum transmission distance novel system could extended times typical hot water transmission system novel system also could cut cost greatly reducing pump work pipe diameter addition efficiency circulation ratio almost unchanged wind power density increased elsevier ltd rights reserved
background post operative chylothorax patients congenital heart disease challenging problem substantial morbidity mortality currently etiology chylothorax poorly understood treatment options limited objectives study aimed report lymphatic imaging findings determine mechanism chylothorax cardiac surgery analyze outcomes lymphatic embolization methods conducted retrospective review patients congenital heart disease post operative chylothorax presented lymphatic imaging intervention july august results based dynamic contrast enhanced magnetic resonance lymphangiography intranodal lymphangiography identified distinct etiologies chylothorax patients traumatic leak thoracic duct branch patients pulmonary lymphatic perfusion syndrome plps patients central lymphatic flow disorder clfd latter defined abnormal central lymphatic flow effusions compartment dermal backflow patients traumatic leak plps combined group patients without clfd intact sixteen patients underwent lymphatic intervention including complete embolization patients resolution chylothorax median days intervention chest tube removal days intervention discharge patients clfd considered separate group intact seven patients underwent lymphatic intervention none survived conclusions patients study nontraumatic chylothorax dynamic contrast enhanced magnetic resonance lymphangiography essential determine etiology lymphatic embolization successful patients traumatic leak plps thus considered first line treatment interventions patients clfd successful resolve chylothorax alternate approaches need developed american college cardiology foundation
well established traumatic brain injury tbi associated development psychiatric disorders however impact psychiatric disorders tbi outcome less well understood examined outcomes patients experienced traumatic subdural hemorrhage whether comorbid psychiatric disorder associated change outcome retrospective observational study performed california office statewide health planning development oshpd nationwide inpatient sample nis patients hospitalized acute subdural hemorrhage identified using international classification diseases ninth revision icd diagnosis codes patients coexisting psychiatric diagnoses identified outcomes studied included mortality adverse discharge disposition osphd diagnoses depression bipolar disorder anxiety associated reduced mortality hospitalization tbi trend toward psychosis schizophrenia effect diagnoses psychosis schizophrenia associated increased adverse discharge depression bipolar disorder effect anxiety associated reduced adverse discharge results confirmed using nis analysis revealed novel associations coexisting psychiatric diagnoses tbi outcomes subgroups decreased mortality increased adverse discharge potential mechanisms include pharmacological effects frequently prescribed psychiatric medications pathophysiology individual psychiatric disorders coding psychiatric illness severely injured patients pharmacological mechanisms validated might lead improved outcome tbi patients studies may provide significant public health benefit
socially constructed identities language practices influence ways students perceive learners problem solvers future professionals research conducted individuals identity engineers less written language used engineering problem solving influences students perceptions construction identities learners future engineers study investigated engineering students identities reflected use language discourses engaged engineering problem solving activity conducted interviews eight engineering students large southeastern university approaches open closed ended materials engineering problems modification gee analysis language use used analyze interviews found pedagogical engineering problem solving uses language common participants likely perceive students highlighting practices expectations language associated student rather emerging engineers whose practices affected conditions professional practice suggest problem solving academic setting may encourage students consider alternative discourses related industry professionalism creativity consequently fail promote connections social worlds beyond classroom learning ways language particular settings produces identities shapes problem solving practices educators engineering professionals gain deeper understanding language shapes ways students describe problem solvers make decisions procedures techniques solve engineering problems
increasingly vitamin deficiency associated number psychiatric conditions particular disorders developmental basis autistic spectrum disorder schizophrenia neurobiological plausibility association strengthened preclinical data indicating vitamin deficiency early life affects neuronal differentiation axonal connectivity dopamine ontogeny brain structure function recently epidemiological associations made low vitamin psychiatric disorders typically associated abnormalities brain development depression alzheimer disease preclinical findings revealing vitamin regulate catecholamine levels protect specific alzheimer like pathology increase plausibility link review attempted integrate clinical epidemiology potential vitamin mediated basic mechanisms throughout review highlighted areas think future research focus crown copyright published elsevier inc rights reserved
examined mechanisms involved development easily learned easily remembered eler heuristic three groups young children years years years trial acquisition procedure used evaluate much children judgment learning depended eler heuristic moreover new experimental paradigm composed six phases pretest four training phases posttest employed implicitly influence validity eler association underlies metacognitive rule results revealed eler heuristic develops early years use reduced implicit training furthermore executive monitoring found account smaller changes observed older children years training developmental perspective findings present coherent picture children learning metacognitive heuristics wherein early automatic implicit learning later followed effortful control elsevier inc rights reserved
complexity internet things iot applications difficulty predict behaviour wireless communications make modelling iot units important research topic iot unit considered two node iot model supports directional wireless communications many approaches model security energy awareness however little known synergistic effect factors application level influence environmental factors noise paper introduces modelling framework model security energy environment issues main attributes allow defining quality service qos iot based applications among others healthcare ones regarded predominant model iot units using feature based modelling methodology adopted software engineering domain result modelling set feature models valid configurations describe energy security environment performance relationships possible constraints support various iot applications feature models select configuration best suited given iot application respect qos requirements feature models represent abstract relationships domain factors need additionally provide experiments determine concrete values modelled features describe experimental system measure energy consumption influencing factors models abstract concrete allow reasoning qos iot applications copyright john wiley sons ltd
accurate location eyes facial image important many human facial recognition related applications attracted considerable research interest computer vision however prevalent methods based frontal pose face applying non frontal poses yield erroneous results paper propose eye detection method locate eyes facial images captured various head poses proposed method consists two stages eye candidate detection eye candidate verification eye candidate detection eye candidates obtained using multi scale iris shape features integral image size iris face images varies head pose changes proposed multi scale iris shape feature method detect eyes cases since utilizes integral image computational cost relatively low extracted eye candidates verified eye candidate verification stage using support vector machine svm based feature level fusion histogram oriented gradients hog cell mean intensity features tested performance proposed method using chinese academy sciences pose expression accessories lighting cas peal database pointing database results confirmed superiority method conventional haar like detector two hybrid eye detectors relatively extreme head pose variations elsevier rights reserved
background delirium dementia cognitive impairment common older hospital patients associated serious adverse outcomes despite delirium often preventable frequently recognized hospital settings may hospital nurses received adequate education training recognizing caring however effective way increasing nurses awareness delirium dementia initiating regular patient screening monitoring guide best practices patients hospital settings known hence current project conducted aims redress situation implementing multi component non pharmacological evidence based intervention patients educating mentoring hospital nurses change practice methods development practice change component informed recent findings implementation science focuses facilitation active ingredient knowledge uptake utilization component focuses educating empowering experienced nurses become cognition champions cogchamps across six wards large australian tertiary referral hospital cogchamps turn educate nursing team members effectively care patients hospital leadership team supportive project directly involved selecting cogchamps cogchamps provided comprehensive education evidence based delirium assessment prevention management practice change management skills receive continuing support research education staff raising awareness upskilling staff delirium assessment adoption best practices preventing managing delirium qualitative quantitative data collected multiple time points evaluate process impact outcome provide clarity regarding effective aspects intervention discussion paper describes study protocol implementation multi component evidence based non pharmacological practices designed improve care older hospital patients findings inform subsequent initiatives directed towards enhancing capacity nursing workforce implement best practices providing high quality care growing patient population throughout acute care hospital stay
background visceral leishmaniasis coinfection hiv aids emerged series disease pattern often results unfavorable responses treatment frequent relapses deaths scarce data available regarding prevalence hiv associated factors among visceral leishmaniasis coinfected patients study sought determine prevalence hiv associated factors among visceral leishmaniasis infected patients methods facility based cross sectional study conducted october august northwest ethiopia cluster sampling technique used select visceral leishmaniasis infected patients serologic parasitological test results used diagnose visceral leishmaniasis hiv diagnosis based national algorithm two serial positive rapid test results case discrepancy two tests uni gold used tie breaker structured questionnaire used collect independent variables data entered using excel analyzed using spss version descriptive statistics logistic regression model used analyze data results total study participants included study response rate hiv visceral leishmaniasis coinfection found age years aor urban residents aor daily laborer workers aor significantly associated hiv visceral leishmaniasis coinfection conclusion hiv visceral leishmaniasis coinfection northwest ethiopia found low age residence employment independently associated hiv coinfection northwest ethiopia better design interventions prevent control hiv coinfection productive age groups age daily laborers
microenvironment influences pathogenesis solid tumors plays outsized role understanding stromal response cancers particularly pancreatic ductal adenocarcinoma evolved host defense tumor offense know although factors processes microenvironment support tumor epithelial cells reappraisal roles stromal elements also revealed potential vulnerabilities therapeutic opportunities exploit high concentration stroma glycosaminoglycan hyaluronan together large gel fluid phase pressures generates recently identified primary sources treatment resistance pancreas cancer whereas relatively minor role free interstitial fluid fluid mechanics perfusion tumors long appreciated less mobile gel fluid phase largely ignored historical technical reasons inability classic methods fluid pressure measurement capture gel fluid phase together dependence xenograft allograft systems inaccurately model tumor vascular biology led undue emphasis role free fluid impeding perfusion drug delivery almost complete oversight predominant role gel fluid phase propose hyaluronan rich relatively immobile gel fluid phase induces vascular collapse hypoperfusion primary mechanism treatment resistance pancreas cancers similar properties may operant solid tumors well revisiting characterizing fluid mechanics modern techniques autochthonous cancers may warranted
introduction birth control pill effective coitally independent method contraception public health milestone last century time combined oral contraception coc formulations pill taking regimens evolved improved safety tolerability maintaining contraceptive efficacy addition protection pregnancy use combined oral contraception confers number significant non contraceptive benefits users coc use also associated well studied risks common side effects generally self limiting improve increasing duration use serious adverse events including venous thromboembolism rare among healthy coc users contraceptive decision making include consideration risks benefits given method versus real consequences unintended pregnancy elsevier ltd rights reserved
sleep sensitive indicator well helpful early warning symptom many psychiatric disorders healthy sleep balanced sleep wake rhythm desirable goals salutary conduct life preventive psychoeducational measures take point non organic sleep disorders commonly associated psychiatric diseases major depressive disorder hypomania mania schizophrenia anxiety disorders alcoholism substance related disorders well dementias sleep disturbances often first symptoms psychiatric disorder thus important early warning signs polysomnography useful tool show characteristic patterns sleep disturbances different psychiatric disorders
changes levels three structurally functionally different important thermoprotectant molecules namely small heat shock proteins shsps trehalose lipids investigated upon heat shock schizosaccharomyces pombe alpha crystallin type shsps hsp hsp induced prolonged high temperature treatment different kinetic profiles shsp null mutants display weak significant heat sensitivity indicating importance thermal stress management heat induction shsps different wild type highly heat sensitive trehalose deficient tps delta cells however trehalose level show significant alteration shsp mutants altered timing trehalose accumulation induction shsps suggest disaccharide might provide protection early stage heat stress elevated amount shsps required later phase cellular lipid compositions two different temperature adapted wild type pombe cells also altered according rule homeoviscous adaptation indicating crucial role adapting environmental temperature changes hsp hsp able bind different lipids isolated pombe whose interaction might provide powerful protection heat induced damages membranes data suggest three investigated thermoprotectant macromolecules play pivotal role thermal stress management fission yeast
dopa introduced part pharmacological therapy parkinson disease spite extensive research additional effective drugs discovered treat brings forward question haver new drugs developed consider one problems preventing discovery new drugs still information pathophysiology neurodegeneration neuromelanin containing nigrostriatal dopaminergic neurons currently widely accepted degeneration dopaminergic neurons substantia nigra pars compacta involves mitochondria dysfunction formation neurotoxic oligomers alphasynuclein dysfunction protein degradation systems neuroinflammation oxidative endoplasmic reticulum stress however initial trigger mechanisms nigrostriatal system still unknown reported aminochrome induces majority mechanisms involved neurodegeneration process aminochrome formed within cytoplasm neuromelanin containing dopaminergic neurons oxidation dopamine neuromelanin normal harmless process healthy individuals intact neuromelanin containing dopaminergic neurons interestingly aminochrome induced neurotoxicity prevented two enzymes diaphorase glutathione transferase explains melanin containing dopaminergic neurons intact healthy human brains
hepatitis virus pathogen associated water pollution contaminated drinking water cause hepatitis outbreaks lead economic losses even threaten human lives difficult detect low levels hepatitis virus water virus must concentrated order quantify accurately present simple rapid efficient technique concentration detection hepatitis virus water data showed adding phosphate buffered saline water pre filtering water adding trizol reagent directly filtration membrane significantly improve concentration efficiency three types filtration membranes studied mixed cellulose ester membrane polyvinylidene fluoride membrane nylon membrane concentration efficiency using mixed cellulose ester membrane pore size highest reaching method used concentrate hepatitis virus water samples donghu lake using sybr green real time reverse transcription polymerase chain reaction analysis detection sensitivity method reached copies concentration efficiency reached
application network technology risk network security gradually increasing order predict likelihood network risks real time time varying markov model tvmm real time risk probability prediction proposed real time risk probability prediction method able predict probability network risk future exactly real time updating state probability transition matrix tvmm model used calculate risk probability network different risk levels network attack environment result shows tvmm higher real time objectivity accuracy traditional markov model
experimental studies shown anogenital distance agd birth reflects androgen concentrations prenatal development predicts adult agd male rodents shortened agd associated compromised reproductive function aim study examine associations agd measures semen quality male partners subfertile couples men attending infertility service provided semen sample completed epidemiological questionnaires lifestyle general health two variants agd anus posterior base scrotum agdas cephalad insertion penis agdap assessed men semen parameters semen volume sperm concentration total sperm counts motility morphology determined following guidelines associations agd measures semen quality tested using multiple regression analyses controlling appropriate covariates significant positive associations agdas measures sperm concentration total sperm count total sperm motile count detected values study represents first analysis agd potential infertile european men showing association perineal length semen parameters however still uncertain utility clinical practice therefore studies warranted confirm extent findings
backgroundcarbohydrate accepted principal nutrient affecting blood glucose diabetes however current guidelines unable specify optimal quantity carbohydrate glycaemic control studies exist describe current practice amongst healthcare professionals giving carbohydrate advice type diabetes present study aims improve understanding degree variation current practice registered dietitians rds describing rds advise patients methodsuk rds contacted national networks asked complete online survey analysed using stata version statacorp college station usa three consultations dietitians patients type diabetes observed followed semi structured interviews dietitians resultsin total complete survey responses received dietitians advice varied according expertise training confidence complexity patient blood glucose treatment respondents advised patients restrict carbohydrate intake either occasionally frequently considering total energy carbohydrate realistic expectation overall theme interviews conflicting priorities three sub themes treatment decisions made difference empowerment advice iii contradictory advice disparity existed observed interview data dietitians rationalise type carbohydrate advice provided conclusionsdietitians advice varies number reasons consensus exists areas carbohydrate awareness advice however clear definitions terms lacking clarification interventions may improve consistency approach improve patient outcomes
although content analyses examined portrayal women objectifying demeaning ways many forms media including several genres music little research explored portrayal women country music current study content analyzed lyrics country songs popular united states across almost three decades portrayal female gender roles objectification women findings revealed country songs less likely portray women traditional roles non traditional roles family roles empowered songs popular first half one prior decades songs also likely refer woman appearance women tight revealing clothing women objects women via slang songs one prior decades furthermore results indicate changes portrayal women appear driven changes lyrics songs sung male artists songs sung female artists present research helps lay foundation future work exploring relations exposure country music female gender role stereotypes attitudes behaviors related objectification women
background psoriasis chronic condition negative impact patients quality life often requires lifelong effective safe treatment objective analysis focused effect secukinumab treatment patient reported health related quality life assessed dermatology life quality index dlqi patients moderate severe psoriasis methods proportion subjects achieving dlqi score response week time dlqi score response sustained dlqi score response week compared secukinumab etanercept results subjects received secukinumab received etanercept dlqi score response rates significantly higher secukinumab etanercept week median time dlqi score response significantly shorter secukinumab versus etanercept weeks majority secukinumab treated subjects achieved dlqi score response week sustained week along reduction psoriasis area severity index total score response limitations placebo comparisons limited maintenance period rerandomization week conclusion secukinumab treatment provided faster greater sustained improvements quality life etanercept weeks consistent greater clinical response
criteria schenkerian analysis much discussed discussions generally informed data kirlin kirlin phillipb probabilistic model hierarchical music analysis thesis university massachusetts amherst begun fill vacuum corpus textbook schenkerian analyses encoded using data structures suggested byyust yust jason formal models prolongation thesis university washington machine learning algorithm based dataset produce analyses reasonable degree accuracy work examine musical features scale degree harmony metrical weight significant performance kirlin algorithm
computer programming important skill engineering computer science students however teaching learning programming concepts skills recognized great challenge teachers students therefore development effective learning strategies environments programming courses become important issue address issue study proposes two tier test based learning system enhance students learning outcomes computer programming courses conducted experiment college computer programming course evaluate effectiveness proposed method experimental results show proposed method improves students attitude toward learning programming language also enhances programming skills
major goal patient protection affordable care act reducing healthcare spending shifting focus healthcare toward preventive care preventive services including fda approved contraception must provided patients without cost sharing aca cost contraception shown increase uptake highly effective birth control methods reduce unintended pregnancy abortion however institutions corporations argue providing contraceptive coverage infringes religious beliefs contraceptive coverage mandate evolving due legal challenges already demonstrated success reducing costs improving access contraception
progress biomechanical modelling human soft tissue basis development new clinical applications capable improving diagnosis treatment diseases cancer well surgical planning guidance interventions finite element method fem one popular techniques used predict deformation human soft tissue due high accuracy however fem associated high computational cost makes difficult integration real time computer aided surgery systems alternative simulating mechanical behaviour human organs real time comes use machine learning techniques much faster fem paper assesses feasibility methods modelling biomechanical behaviour human liver breathing process crucial guiding surgeons interventions critical track deformation specific kind biopsies accurate application radiotherapy dose liver tumours purpose different regression models investigated including three tree based methods decision trees random forests extremely randomised trees two simpler regression techniques dummy model linear regression order build validate models labelled data set constructed modelling deformation eight vivo human livers using fem best prediction performance obtained using extremely randomised trees mean error samples error achieved results lay foundation future development real time software capable simulating human liver deformation breathing process clinical interventions elsevier ltd rights reserved
background growing evidence points association daily light exposure mood mood disorders recent studies demonstrated higher illuminance daytime may positively associated hyperthymic temperament lower illuminance daytime may positively associated cyclothymic temperament however possible determine whether hyperthymic cyclothymic temperament induces higher lower illuminance via heliotropism non heliotropism whether higher lower illuminance induces hyperthymic cyclothymic temperament via light effects methods order elucidate questions sought compare bipolar temperaments residents live regions varying levels sunshine japan large islands hokkaido honshu shikoku kyushu sapporo hokkaido oita kyushu located degrees degrees latitude differ significantly mean yearly sunshine investigated data subjects sapporo oita including data temperament evaluation memphis pisa paris san diego auto questionnaire version temps results multiple regression analyses revealed latitude sapporo oita effect predicted significant variance hyperthymic temperament temperaments limitations limitation present study small significant difference age subjects sapporo oita therefore included age multiple regression analysis second several climate factors sunshine significantly different sapporo oita exclude effects completely finally consider factors psychosocial factors might affected bipolar temperaments conclusions present findings suggest relatively lower latitude potentially via sunshine may induce hyperthymic temperament elsevier rights reserved
erasable itemset mining approach mining itemsets low profits large scale product databases order solve financial crises plants manufacturing industries previous erasable itemset mining methods deal static product databases ignore characteristics items values extract erasable itemsets therefore approaches may fail solve financial crises plants iterate significant number mining processes order deal real time product data accumulated plants real world paper propose new tree based erasable itemset mining algorithm dynamic databases finds erasable itemsets considering weight conditions incremental databases proposed algorithm uses new tree list data structures performing mining operations efficiently furthermore proposed algorithm capable reducing number mined erasable itemsets considering different weight information items within product databases also compare proposed approach tree based state art methods performing runtime memory pattern quality scalability comparisons respect various real synthetic incremental datasets show proposed algorithm outstanding comparison previous methods elsevier ltd rights reserved
data centers hosting distributed computing systems consume huge amounts electrical energy contributing high operational costs whereas utilization data centers continues low moreover data center generally consists heterogeneous servers different performance energy failure fully consider heterogeneity servers lead sub optimal energy saving performance study employ game theoretic approaches model problem minimizing energy consumption stackelberg game model system monitor plays role leader maximize profit adjusting resource provisioning whereas scheduler agents act followers select resources obtain optimal performance addition model problem minimizing average response time tasks noncooperative game among decentralized scheduler agents compete one another sharing resources several algorithms presented implement game models simulation results demonstrate proposed technique immense potential improve energy efficiency dynamic work scenarios without compromising service level agreements
continuous flock starlings optimization cfso applied optimization array coils usually used transcranial magnetic stimulation cfso continuous equivalent model flock starlings optimization fso algorithm expressed terms state space representation trajectories cfso particles explore space solutions optimization problem obtained direct application closed forms suitable time windows tws thanks representation terms state equations possible drive trajectories passing convergence divergence vice versa exploration exploitation moreover possible refine solution reducing amplitude tws optimization procedure enhancing performance numerical fso algorithm use closed forms makes cfso easy implemented accurate quality solution validation results presented performances different optimal array coils configurations compared
purpose investigate factors lead willingness try electronic cigarettes among adolescents methods sample year old pupils completed questionnaire results smoking status significantly predicted one third variance willingness try electronic cigarette significantly predicted positive prototype smoker stylish negative prototype electronic cigarette user unattractive moreover tobacco flavored electronic cigarettes less favorable alternative flavors fruit chocolate mint conclusions findings provide evidence flavored electronic cigarettes appealing adolescents smokers non smokers current past electronic cigarette users never users
difficult design simple effective learning algorithm based gradient pid neural networks neurons discontinuous transfer functions new line algorithm proposed according signal flow graph sfg theory paper gradients could calculated directly sfgs pid neural networks method moreover adaptive teaming rate designed guarantee convergence algorithm lyapunov stability theory simulation results show algorithm effective line learning algorithm pid neural networks nonlinear dynamic system identification
childhood trauma associated different psychiatric disorders adulthood disorders often presented comorbidity depression objective establish relationship psychiatric comorbidities childhood traumatic events patients depression chile methods three hundred ninety four patients major depression assessed using mini international neuropsychiatric interview screening childhood trauma results social anxiety disorder associated witnessed domestic violence childhood childhood physical abuse physical injury associated physical abuse sexual abuse non relative posttraumatic stress disorder associated physical injury associated physical abuse sexual abuse relative sexual abuse non relative antisocial personality disorder associated traumatic separation caregiver alcohol abuse family member physical abuse sexual abuse non relative panic disorder associated sexual abuse relative generalized anxiety disorder associated sexual abuse non relative conclusions clinical recognition required patients seeking help depression primary care recognition must take account patient current psychiatric comorbidities adverse childhood experiences
solar energy one popular clean energy sources promising alternative fulfill increasing energy demands modern society solar cells long intensive research attention harvesting energy sunlight high power conversion efficiency low cost however power outputs photovoltaic devices suffer fluctuations due intermittent instinct solar radiation integrating solar cells energy storage devices self powering systems may solve problem simultaneous storage electricity manipulation energy output review summarizes research progress integration new generation solar cells supercapacitors emphasis structures materials performance new design features current challenges future prospects discussed aim expanding research development field
research shown emotional events remembered better neutral events might also elicit increase false memories present study designed disentangle influences valence arousal event memory misinformation paradigm participants shown six types photographs positive high low arousal negative high low arousal ambiguous neutral half exposed misleading information recognition test assessed memory correct false central peripheral details negative ambiguous events elicited fewer correct false memories peripheral details positive neutral events regardless previous exposure misinformation arousal improved memory correct central details negative valence arousal inhibited control participants tendency endorse false central details power emotion overruled power suggestion however latter effect disappeared previous exposure misinformation results discussed light earlier research emotion cognition recent motivational theories implications forensic practice
paper proposes axial flux modulation permanent magnet machine sensorless control strategy wheel application electrical vehicles vernier structure integrated axial flux machine include magnetic gear effect improve output torque sensorless control strategy proposed machine including initial rotor position estimation rotating position estimation proposed flux modulation motors paper initial rotor position estimation based technique rectangular pulse voltage injection rotating rotor position estimation based sliding mode observer smo saturation effect inductances theoretical basis rectangular pulse voltage injection makes stator parameter variation different loads affects smo estimation overcome problem novel online parameter self adjustment procedure smois introduced machine design sensorless control performance verified simulation prototype experiments
background evidence seasonality bipolar affective disorder bad preponderance atypical symptoms bipolar depressive episodes also seen winter type seasonal affective disorder differences seasonal symptoms bad appropriate comparison populations scrutinised small studies methods symptoms described seasonal pattern assessment questionnaire spaq compared patients bad patients consulting general practitioners statistical analyses adjusted differing age gender distributions two groups results compared general practice patients subjects bad reported greater seasonal fluctuations mood one measure bad subjects reported increased seasonal changes social activity greater weight fluctuation year striking differences sleep patterns bad subjects slept significantly throughout year slept mean winter summer versus difference general practice group general practice group bad patients rated seasonal changes well least moderate problem limitations spaq designed screening instrument seasonal affective disorder studies nature reported differences notably social activity weight changes may reflect secondary psychosocial effects bad conclusions seasonal changes notably winter hypersomnia identified patients bad symptoms may respond treatments light therapy used recurrent winter depression elsevier rights reserved
context mass cost mechanical strength materials must jointly optimized necessary experimental data quickly available sufficiently robust make efficient conception choices thermomechanical fatigue standard tests usually allow comparing material temperature strain ranges although differences thermal properties conductivity thermal expansion could make significant deviations thermal flux applied particularly structure forced heat flux operating regimes new protocol proposed order compare specific resistances metallic materials thermomechanical fatigue easily rank materials according lifetime thermomechanical loadings strain range temperature amplitude determined heat flux applied industrial part method based complete numerical analysis determine experimental loading conditions temporal evolution temperature mechanical strain representative thermomechanical loading observed tmf critical areas part tmf tests hollow specimens carried rank materials temperature strain amplitude different alloys whereas heat flux identical materials ranking list based tmf resistance determined according lifetimes heat flux controlled tests method tested exhaust parts demonstrates superiority cast irons others whereas intrinsic isotherm mechanical properties suggested alternative classification obtained ranking confirmed experimental tests industrial structures elsevier ltd rights reserved
accurate monitoring battery cell temperature indispensible design battery thermal management system obtain internal temperature battery cell online adaptive temperature estimation method based kalman filtering equivalent time variant electrical network thermal eent model proposed eent model uses electrical components simulate battery thermodynamics model parameters obtained least square algorithm discrete state space description eent model kalman filtering based internal temperature estimator developed moreover considering possible time varying external heat exchange coefficient joint kalman filtering jkf based estimator designed simultaneously estimate internal temperature external thermal resistance several experiments using hard cased lifepo cells embedded temperature sensors conducted validate proposed method validation results show eent model expresses battery thermodynamics well based temperature estimator tracks real central temperature accurately even poor initialization jkf based estimator simultaneously estimate central temperature external thermal resistance precisely maximum estimation errors jkf based estimators less degrees degrees respectively elsevier rights reserved
according consciousness involvement human learning roughly classified explicit learning implicit learning contrasting strongly explicit learning clear targets rules school study mathematics learning implicit acquire new information without intending research psychology indicates implicit learning ubiquitous daily life moreover implicit learning plays important role human visual perception past years well known machine learning models aimed simulate explicit learning work modeling implicit learning relatively limited especially computer vision applications article proposes novel unsupervised computational model implicit visual learning exploring dissipative system provides unifying macroscopic theory connect biology physics test proposed dissipative implicit learning model dilm various datasets experiments show dilm provides good match human behavior also improves explicit machine learning performance obviously image classification tasks
historical analysis reproductive politics canadian north necessitates careful reading local circumstances regarding feminism sovereignty language colonialism access health services differed regionally culturally features conditioned however international discussions family planning fixated twinned concepts unchecked population growth poverty language debates crept discussions reproduction birth control northern canada producing state logic despite low population density endemic poverty north necessitated aggressive family planning measures
article aeolian sand sample study inner mongolia baotou area determine aeolian sand maximum dry density optimum moisture content basis aeolian sand cohesion internal friction angle measured quick direct shear test aeolian sand optimum moisture content near largest compactness bearing capacity retaining wall model regarded aeolian sand fillers determined bearing capacity change aeolian sand wrapped compared experimental results showed aeolian sand wet compacted state cohesion kpa internal friction angle degrees aeolian sand bearing capacity kpa plate loading test aeolian sand wrapped geotextile bearing capacity kpa aeolian sand research baotou area provides useful reference construction highway railway application wrap reinforced retaining wall new retaining structure region aeolian sand treated special filling material structures
recent research demonstrated impairments social cognition associated multiple sclerosis present work asks whether impairments associated atypical moral judgment specifically assessed whether patients able integrate information intentions outcomes moral judgment appropriateness punishment judgments case third party acts found complex pattern moral judgments patients although moral judgments comparable controls specific types acts accidental intentional harms nevertheless judged behaviors less appropriate endorsed severe punishment across board also likely report others responses would congruent analyses suggested elevated levels externally oriented cognition due occurring alexithymia explain effects additionally found distinction appropriateness punishment judgments whereby harmful outcomes influence punishment judgments greater extent appropriateness judgments preserved despite observed disruptions affective motivational components empathy current results inform two process model intent based moral judgments well possible strategies improving quality life patients
psychiatric disorders linked variety biological psychological contextual causes consequences laboratory studies elucidated importance several key physiological behavioral biomarkers study psychiatric disorders much less known role biomarkers naturalistic settings gaps largely driven methodological barriers assessing biomarker data rapidly reliably frequently outside clinic laboratory mobile health mhealth tools offer new opportunities study relevant biomarkers concert types data self reports global positioning system data review provides overview state emerging field describes examples literature mhealth tools used measure wide array biomarkers context psychiatric functioning psychological stress anxiety autism substance use also outline advantages special considerations incorporating mhealth tools remote biomarker measurement studies psychiatric illness treatment identify several specific opportunities expanding promising methodology integrating mhealth tools area may dramatically improve psychiatric science facilitate highly personalized clinical care psychiatric disorders elsevier ltd rights reserved
fostering students computer programming ability recognized important challenging educational issue highly related process problem solving however existing computer programming instruction mainly focuses training programming language syntax programming skills problem solving concepts often ignored thus study integrated scratch project based learning approach proposed embed problem solving scenarios programming learning tasks test effectiveness proposed approach total secondary school students including average students mathematics gifted students participated project based learning activity experimental results showed proposed learning approach could fitted types students however mathematics gifted students outperformed average students terms problem solving performance learning attitude learning motivation furthermore average mathematics gifted students showed significant progress learning activity implying proposed approach benefited students matter whether tended gifted mathematics
background induced abortion one greatest human rights dilemmas time yet abortion common experience every culture society according world health organization ethiopia fifth largest number maternal deaths unsafe abortion estimated account maternal deaths ethiopia youth disproportionately affected consequences unsafe abortion objective study therefore determine magnitude identify factors associated abortion among female wolaita sodo university students methods descriptive cross sectional study conducted wolaita sodo university may june data collected randomly selected female students using structured pre tested questionnaires results rate abortion among students found per women making three fold national rate abortion ethiopia women aged virtually abortions induced half reported safe students history alcohol use first year enrolled faculties post grade natural science background higher risk abortion counterparts reported sexual experience less half respondents ever heard emergency contraception sexually experienced ever used condom conclusions high rate abortion detected among female wolaita sodo university students half abortions took place initiated unsafe circumstances knowledge students legal safe abortion services found considerably poor imperative improved sexual health education focus safe legal abortion services rendered wider availability youth friendly family planning services realized universities places young men women congregate
paper dynamic model shape memory alloy sma flexinol actuator wire developed simulated model nonlinear hysteresis behavior parameters obtained easily using manufacturer data sheet developed model served investigate sma behavior design control applications simulation results using tlab simulink verified dynamic model behavior affirmed potential modeling procedure results showed flexinol wire powerful actuator large strain high power weight ratio
review explicates past present future theory research concerning audience perceptions media well effects perceptions media audiences sections examine media perceptions media effects perceptions first identify various psychological concepts processes involved generating media related perceptions first section analyze two types media perceptions media trust credibility perceptions bias perceptions focusing research hostile media perception cases address potential consequences perceptions second section assess theory research perceptions media effects often referred presumed influence consequences referred influence presumed influence examples presumed influence evaluate literature persuasive press inference third person perception bodies research media perceptions media effects perceptions featured prominently top journals field mass communication past years bring together one synthetic theoretical review
racial inequalities criminal justice pressing problems policymakers prior literature suggests elected officials promulgate punitive racially disparate criminal justice policies due partisanship racial fears scholarship yet explain elected officials address racial problems criminal processing article introduces framework racial disparity reform policymaking racial disparity reform policy seeks reduce distinctions criminal justice institutions treatment racial groups elected officials pursue policies due ideological beliefs civil rights ideals political interests appearing solve social problems using original database policy enactments article first presents distribution types reform measures adopted elected officials states examines social political explanations state legislatures executives adopt racial disparity reforms policy enactment predicted worsening problems racial disproportion criminal processing democratic control elected branches absence judicial efforts improve racial fairness within state criminal justice system similar dynamics encourage development different measures types within policies ideological problem solving explanations racial disparity reform show potential elected officials forge racially criminal justice practices
first episode psychosis frequently manifest young adulthood impact severely lives affected individuals relatives cases first episode psychosis preceded long term prodromal phase heterogeneous symptomatology considerable functional impairment early identification individuals high risk psychosis enables timely implementation preventive strategies early diagnosis start adequate therapy including pharmacological psychotherapeutic socio therapeutic approaches essential prognosis disease aims best achieved specialised early intervention centres young people experiencing first episode psychosis many countries centres form part standard care provisions german speaking areas remain exception early intervention therapy centre fritz urban offers patient care persons risk psychosis well individuals early phase disease low threshold counselling open supportive attitude part multidisciplinary team availability regular contact persons preservation patient autonomy strengthening patient self esteem peer consultation peer support designed create positive first contact experience psychiatric care system treatment offer pronounced psychotherapeutic orientation early application individual placement support ips strategies seeks reduce symptoms also contribute functional recovery
study focuses parameter identification problems pseudo linear systems main goal present recursive least squares rls estimation methods based auxiliary model identification idea decomposition technique first auxiliary model based rls algorithm given comparison second improve computation efficiency decomposition based rls algorithm presented system identification missing data interval varying rls algorithm derived estimating system parameters furthermore study uses decomposition technique reduce computational cost interval varying rls algorithm introduces forgetting factors track time varying parameters simulation results show proposed algorithms work well
active sonar processing discrimination target versus clutter significant challenge whereas conventional processing often uses target kinematics limit possible target tracks recently shown frequency domain information based waveguide invariant principle also incorporated limit possible target tracks environmentally robust fashion paper presents physics based signal processing methods extract information target track striations target spectrogram formed echo spectra active sonar pulse repetition interval target tracking information formulated post track likeliness statistic extracted sonar data image processing techniques results demonstrated shallow water sonar data collected target reverberation experiment trex expected physics based signal processing algorithms discussed provide enhanced clutter rejection improve tracking performance
tutte embedding one popular approaches computing parameterizations surface meshes computer graphics geometry processing popularity attributed simplicity guaranteed bijectivity embedding relation continuous harmonic mappings work extend tutte embedding hyperbolic conesurfaces called orbifolds hyperbolic orbifolds simple surfaces exhibiting different topologies cone singularities therefore provide flexible useful family target domains hyperbolic orbifold tutte embedding defined critical point dirichlet energy special boundary constraints proved bijective also satisfying set points constraints efficient algorithm computing embeddings developed demonstrate powerful application hyperbolic tutte embedding computing consistent set bijective seamless maps pairs collection shapes interpolating set user prescribed landmarks fast robust manner
increasing number case reports series document safe effective use electroconvulsive therapy ect children adolescents young adults autism spectrum disorder engage severe intractable repetitive self injurious behavior sib without environmental operant function although treatment effective patients typically remain highly dependent frequent maintenance ect ect maintain suppression sib achieved acute course patients receivem ectas frequently every days regimen quite burdensome patient patient family long term effects regimens starting early childhood unknown review explore expanding literature supporting use ect suppressing severe sib associated autismspectrumdisorder also focus possible development alternate nonconvulsive focal forms brain stimulation might replace frequent ector reduce frequently patient needs receive although scarce clinical data currently available supporting latter treatments future studies clearly indicated
aim aim study analyze effects aging viscoelastic properties upper trapezius sternocleidomastoid scm muscle transition lying sitting position materials methods study included older mean age years younger years women tone stiffness elasticity scm measured means myotonometry myotonpro lying sitting position results compared using twoway analysis variance results irrespective position older women presented significantly higher muscle tone stiffness elasticity younger subjects groups transition lying sitting position resulted decrease scm stimulated increase tone stiffness elasticity degree changes study groups similar except absolute value elasticity significantly higher increase older women younger subjects conclusion age contributes increase stiffness tone scm well decrease elasticity muscles female subjects contrast age exerts slight effect mechanical properties muscles transition lying sitting position elsevier ireland ltd rights reserved
epilepsy reported occur individuals autism spectrum disorder asd previous studies across world found prevalence estimates ranging examined parent reported prevalence occurring epilepsy asd recent national survey children health analyses accounted survey weights account complex sampling design overall analytic sample children ages children asd prevalence children epilepsy prevalence epilepsy reported occur asd cases children asd occurrence epilepsy associated increasing child age female gender intellectual disability speech problems lower socioeconomic status
background patients bipolar spectrum disorders bsd frequently report medically unexplained somatic symptoms however prevalence consequences treatment outcome currently unknown methods estimate prevalence somatic symptoms bsd conducted systematic review meta analysis empirical studies published odds somatic symptoms bsd compared unipolar depression upd general population mixed psychiatric controls studies retrieved four electronic databases utilizing boolean operations reference list searches pooled data estimates derived using random effects methods results studies eligible inclusion yielding patients estimated prevalence somatic symptoms bsd estimated prevalence bsd persons somatic symptoms persons bsd higher prevalence somatic symptoms compared population mixed psychiatric controls persons bsd similar prevalence somatic symptoms compared upd controls limitations study correlational thus causal inferences made reporting somatic symptoms likely varies bsd severity subtype studies reported insufficient information regarding comorbid medical conditions medications conclusions persons bsd suffer somatic symptoms rate nearly double general population rate similar persons upd results suggest utility integrated care model primary care specialist physicians collaborate mental health professionals jointly address psychological bodily symptoms elsevier rights reserved
paper presents multi channel multi technique electrochemical instrument size power performance portable applications point care diagnosis wearable sensing toxic chemical detection composed custom analog interface commercial low power microcontroller portable instrument capable dynamically adapting wide input current range exhibited many electrode sensor types observed transient response many electrochemical techniques instrument generate several standard electrochemical stimulus waveforms arbitrary waveform independently parallel multiple channels streaming measurement results usb host portable instrument tested across multiple conditions commercial benchtop electrochemical instrument potassium ferricyanide solution maximum normalized root mean square difference test results commercial instrument less cementing system robustness
cross sectional visualization anatomical structures dicom viewers usually presented parallel slices visualizing inner ear concept unfavourable due spiral shape cochlea radial slicing central axis known midmodiolar view advantageous therefore custom dicom viewer developed allows visualization cochlea midmodiolar slice plane rotates around central axis cochlea always cutting latter radially program written using open source libraries itk vtk gdcm rotation axis defined placing two points modiolus within conventional slice visualization dataset midmodiolar visualization calculated based axis scrolling mouse wheel rotates slice plane around axis displaying midmodiolar slices variable angles measurement options provided well interactive placement marker points whose coordinates exported post processing programs program used multiple applications including determination cochlear dimensions especially length post operative positions cochlear implant electrode carriers computer aided design models cochlea generated exported marker points proposed dicom viewer directly focuses needs cochlear visualization thus making valuable tool related research ease use facilitates future clinical use pre operative selection optimal electrode carrier length based patient cochlear length
chopper chelator cuprizone serves valuable chemical tool induce consistent reproducible demyelination central nervous system however daily preparation fresh cuprizone powder mixed finely ground rodent chow might well particular health problem alternative methods fabrication cuprizone containing pellets available effectiveness method however known present study compared whether intoxication cbl mice cuprizone mixed ground rodent chow induce demyelination similar extent compared cuprizone pellet intoxication protocol found feeding cuprizone ground chow provides strong well defined reproducible demyelination along increased accumulation microglia axonal damage corpus callosum whereas analyzed parameters significantly less distinct mice fed cuprizone containing pellets equivalent concentration cuprizone week even higher concentration cuprizone pellet formulation less potent compared study illustrates established protocol cuprizone intoxication mixed ground rodent chow gold standard method achieve consistent reproducible demyelination cuprizone loses effectiveness pellet formulation needs addressed subsequent studies
individuals problem solving deficits higher levels neuroticism hopelessness increased risk suicide yet little known interrelationships vulnerability characteristics sample low income primary care patients examined potential mediating role hopelessness relation neuroticism suicidal behavior potential moderating role social problem solving ability participants completed self report questionnaires suicidal behaviors questionnaire revised social problem solving inventory revised beck hopelessness scale neo five factor inventory models tested using bootstrapped moderated mediation techniques significant indirect effect neuroticism suicidal behavior hopelessness indirect effect moderated social problem solving ability patients greater neuroticism also manifest greater levels hopelessness turn suicidal behavior relations strengthened lower levels social problem solving interventions increase social problem solving ability reduce hopelessness may reduce suicide risk
paper reports ongoing effort developing new instructional model improve cognitive learning student motivation undergraduate manufacturing engineering education model computer animation simulation program incorporated hands real world experiments paper describes interactive computer program developed animating simulating machining processes undergraduate machining course teach representative example student projects provided demonstrate computer simulation employed new instructional model qualitative quantitative evaluations conducted assess students attitudes toward computer program helps students understand fundamental machining concepts theories evaluation results show developed instructional model positive impact enhancing increasing students cognitive learning machining concepts theories
basis integration dual process models information processing lens model framework person perception conducted two studies investigate whether self perceivers could detect implicit disposition video feedback behavioural cues whether cues used explicit dispositional inferences conditions maximized presumed self perception process using approach differed previous research used following detailed stepwise self perception procedure specific explicit measure compared global explicit measure iii disgust sensitivity domain clear unambiguous cues assumed low self presentation bias results two studies disgust sensitivity provide first evidence assumed process regard bodily reaction cues regard facial expression cues novel findings suggest people get know unconscious selves better supporting conditions met right behavioural cues attended additional boundary conditions self perception process investigated using display rules need closure study copyright john wiley sons ltd
background experts recommend clinicians assess motivational factors initiating care pediatric obesity currently well established clinical tools available assessing motivation youth obesity families represents important gap knowledge since motivation related information may shed light patients might fail complete treatment programs study designed evaluate measurement properties utility readiness motivational interview families rmi family structured interview utilizes motivational interviewing approach assess motivational factors youth parents examine degree motivation motivation related concordance youth parents related making changes lifestyle habits managing obesity youth methods prospective study include youth obesity body mass index bmi percentile years old parents study conducted two primary level multidisciplinary obesity management clinics based children hospitals alberta canada participants recruited enrolled referral clinics prior initiating clinical care youth parent complete rmi family similar baseline months post baseline individual youth parent family level across youth parent responses interview questions scored aspects interview administration fidelity motivational interviewing tenets rmi family also examined test retest reliability youth data collected time point include demography anthropometry lifestyle habits psychosocial functioning health services utilization cross sectional longitudinal associations individual family level interview scores rmi family clinical measures examined discussion measurement tool drawing family centered care motivational interviewing rmi family designed increase understanding role motivational factors pediatric obesity management allowing healthcare providers policymakers manage pediatric obesity effectively efficiently findings help create innovative tailored model health care delivery uses resources judiciously designed best meet families needs
cycling induced automatic control functional electrical stimulation provides means therapeutic exercise functional restoration people affected paralysis cycling induced functional electrical stimulation various muscle groups stimulated according cycle crank angle however kinematic constraints cycle rider system stimulation typically applied subsection crank cycle therefore systems considered switched control systems autonomous state dependent switching potentially unstable modes previous studies included electric motor system provide additional control authority studies considered effects switched control stability analysis motorized functional electrical stimulation cycling system paper model motorized cycle rider system functional electrical stimulation developed includes effects switched control input novel switching strategy electric motor designed provide assistance regions crank cycle kinematic effectiveness rider muscles low switched sliding mode controller designed global exponentially stable tracking desired crank trajectory guaranteed via lyapunov methods switched systems despite parametric uncertainty nonlinear model unknown time varying disturbances experimental results five able bodied passive riders presented validate control design developed control system achieves average cadence tracking error revolutions per minute desired trajectory revolutions per minute note practitioners autonomous systems designed rehabilitation functional assistance people disabilities paralysis potential maximize rehabilitative outcomes improve quality life millions people disorders paralysis drastically reduce person ability complete tasks due loss neuromuscular control functional electrical stimulation activate paralyzed muscles restoring functional ability automated application electric current neuromuscular system applied task cycling rehabilitative empowering however cycling induced functional electrical stimulation limited capability rider muscles electric motor typically added accommodate rider ability support stability response muscle electrical stimulation uncertain time varying nonlinear switching control input across multiple muscle groups rider electric motor make guaranteeing stability performance challenging paper presents novel approach challenge controlling motorized cycling systems functional electrical stimulation considers switching effects guarantees exponentially stable tracking desired crank trajectory experimental results indicate control system may applied rehabilitative cycling task directions future research aimed implementation developed control system patient populations paralysis quantify impact therapeutic outcomes muscle function neuroplasticity
primary headache disorders including migraine common neurological disorders presenting hospital episodic syndromes may associated migraine including recurrent gastrointestinal disturbances abdominal migraine cyclic vomiting often pre date occur onset migraine child risk developing headache condition purpose review evaluate two common episodic syndromes abdominal migraine cyclic vomiting syndrome including pathophysiology common presentations diagnostic criteria differential diagnosis red flag features outlined approach diagnostic work offered finally provide evidence based review management options long term prognosis future research include randomized trials acute preventive treatment disorders well research whether early intervention prevent progression migraine mitigate migraine severity
objective purpose current study identify association polymorphisms insulin like growth factor receptor igf gene insulin like growth factor receptor igf iir gene osteoporosis postmenopausal women han chinese materials methods case control study involved patients postmenopausal osteoporosis age matched controls genotype polymorphisms igf igf iir using restriction fragment length polymorphisms rflp polymerase chain reaction pcr assay bmd values lumbar spine femoral neck forearm measured using dual energy ray absorptiometry serum igf investigated enzyme linked immunosorbent assay results data showed distributions genotype allele igf gene polymorphism significantly frequent osteoporotic women controls conditional logistic regression revealed genotype igf statistically associated osteoporosis adjustment age menopause duration bmi genotype still significantly associated increased risk osteoporosis osteoporotic women genotype igf found lower values serum igf bmd forearm femoral neck compared genotype conclusions results suggested igf gene polymorphism may affect susceptibility osteoporosis postmenopausal women han chinese may change serum igf level
purpose reviewto discuss recent advances medical management glaucoma highlight future medical therapies currently development recent findingsin latanoprost xalatan approved united states new chemical entity new class prostaglandin analogs topical treatment ocular hypertension glaucoma period late additional new chemical entities fixed dose combinations formulation improvements new classes ocular hypotensive medications approved worldwide summarize new pharmacological treatments currently clinical trials new classes new molecules new delivery systems summaryalthough challenges medical treatment glaucoma exist particularly patient adherence medical therapy remains first line treatment almost glaucoma patients new medications glaucoma therapy currently available patients multiple drugs novel mechanisms action new formulations new delivery mechanisms currently development
pyrosequencing targeting hypervariable rdna used investigate bacterial diversity river roof harvested rainwater rhrw used potable purposes rural households luthengele village eastern cape province south africa phylum proteobacteria dominated data set reads reads could classified known phyla probability higher unclassified bacteria class level classes betaproteobacteria reads alphaproteobacteria verrucomicrobiae planctomycetacia sphingobacteria dominated data set samples although class verrucomicrobiae constituted sequences sequences river sample class represented observed sequences sample bacteria community structure clearly showed significant similarities rhrw differences river water control sample suggesting different levels contamination environmental factors affecting various water sources moreover signatures potential pathogens including legionella acinetobacter pseudomonas clostridia chromobacterium yersinia serratia detected proportions legionella relatively higher suggesting potential health risk households using rhrw work provides guidance prioritizing subsequent culturable quantitative analysis ensure potentially significant pathogens left risk estimations
objectivespremenstrual syndrome pms premenstrual dysphoric disorder pmdd involve emotional behavioral physical symptoms however little understanding psychological factors contribute disorders hypothesized rumination form depressive self focused attention related premenstrual distress methodstudy involved women meeting criteria mild pms moderate severe pms pmdd using retrospective self report study involved women meeting diagnostic criteria pms pmdd pmd group healthy controls pmd group following day symptom monitoring participants studies completed questionnaires rumination anxiety sensitivity coping styles resultsrumination strongly related premenstrual disorders using retrospective prospective reports well categorical continuous approaches classification premenstrual distress conclusionsrumination transdiagnostic factor psychopathology may contribute onset maintenance premenstrual distress
performance digital control scheme applied inverters power electronic structures significantly suffer due time delays time delays linear nonlinear example linear delay delay due sampling control calculation application new voltage state results constant delay present control cycle example non linear delay inverter dead time different depending selected switching state direction load current types delays well known addressedin literature time known solutions result significantly complicated hardware software implementations introduction mpc power electronics gives new unique opportunity compensate types delays clear effective way done including delays linear non linear model predictions illustration paper presents mpc based design closed loop current control linear delay compensation voltage source inverters paper also proposes variable rate mpc based voltage modulator combines harmonic suppression inverter dead time compensation main points paper illustrated extensive simulation experimenal results
background retrotransposons comprise ubiquitous abundant class eukaryotic transposable elements members class rely reverse transcriptase activity produce dna copy element rna template however activities retrotransposon encoded polyprotein may differ diverse retrotransposons polyprotein domains corresponding activities may evolutionary history independent reverse transcriptase thus underlying modular view evolution retrotransposons furthermore transposable elements independently evolve similar domain architectures acquiring functionally similar phylogenetically distinct modules convergent evolution retrotransposons may ultimately suggest similar regulatory pathways underlying lifecycle elements results provide new examples convergent evolution retrotransposons species two unrelated taxa green plants parasitic protozoan oomycetes present study first analyzed available genomic sequences oomycete species characterized two groups gypsy long terminal repeat retrotransposons namely chronos archon subgroup non long terminal repeat retrotransposons results demonstrated retroelements three groups independently acquired plant related ribonuclease domains process closely resembles evolution retrotransposons genomes green plants addition showed chronos elements captured chromodomain mimicking process chromodomain acquisition chromoviruses another group gypsy retrotransposons plants fungi vertebrates conclusions repeated strikingly similar acquisitions ribonuclease domains chromodomains different retrotransposon groups unrelated taxa indicate similar selection pressure acting elements thus major trends evolution structural composition retrotransposons characterizing trends may enhance current understanding retrotransposon life cycle
present system called cygnet makes easy use implement media rich interactive cloud services usage simplicity achieved providing simple powerful mechanism makes device first class network accessible resource user dynamically bind service time implementation simplicity achieved providing development runtime environment identical typical linux distribution running local machine cygnet cloud thus transparent developers users latter concern simply choosing devices via wish interact services system supports classes services optimized difficult class requires gpu render content real time designing implementing cloud transparent system class presents number significant technical challenges describe overcame challenges evaluate performance system cloud based gpu rendering
registry databases increasingly used comparative effectiveness research cancer databases reflect real world patient population physician practice thus natural sources comparing multiple treatment scenarios associated long term clinical outcomes registry databases usually include incident prevalent cohorts provide valuable complementary information patients recent diagnoses incident cohort well patients long term follow data prevalent cohort however utilizing data derive valid inference poses two major challenges data prevalent cohort random samples target population may substantial differences baseline characteristics patients treatment arms influences decisions treatment selection cohorts article extend propensity score methodology observational studies involve prevalent incident cohorts assess effectiveness radiation therapy seer medicare patients diagnosed stage breast cancer specifically utilize incident cohort estimate propensity receiving combine data incident prevalent cohorts estimate effect adjusting propensity scores model evaluate proposed method simulations demonstrate proposed propensity score method simultaneously removes sampling bias selection bias several assumptions canadian journal statistics statistical society canada
research examined people ability detect behavior change simulated child targets affected clinical experience assessment method use using summary assessment methods widely employed research clinical practice inexperienced experienced clinical staff detected changes overall frequency targets aggressive behavior uniquely influenced changes targets reactions social events using contextualized assessment methods focused conditional reactions experienced staff showed greater sensitivity novices context specific changes targets aggressive prosocial reactions aversive events experienced staff also showed greater sensitivity context specific changes overall impressions change aggression findings show clinically experienced judges become attuned ifaeuro broken vertical bar thenaeuro broken vertical bar contingencies children social behavior summary assessment methods may hamper detection change processes
synopsis although osteoarthritis traditionally considered disease older age hip knee affect younger adults profound impact psychosocial well work capacity obesity history traumatic knee injury anterior cruciate ligament rupture meniscal tear key risk factors accelerated development knee structural hip deformities including contributing femoroacetabular impingement syndrome strong predictors early onset hip view associations rising rates obesity sports injuries concerning may signal future surge incidence among younger people assessment hip knee younger people focus patient centered history comprehensive physical examination performance based measures patient reported outcome measures enable monitoring symptoms function time referral imaging reserved people presenting atypical signs symptoms may indicate diagnoses nonpharmacological approaches core strategies management hip knee younger people include appropriate disease related education activity modification including work related tasks physical therapist prescribed exercise programs address identified physical impairments weight control weight loss high quality evidence shown benefit arthroscopy knee published clinical trials support use hip arthroscopy referral joint conserving joint replacement surgery considered nonpharmacological pharmacological management strategies longer effective
advances healthcare considerably improved life expectancy human population last century brought new challenges live longer capacity cognitive aging increases consequently noted decline cognitive performance elderly domains reasoning problem solving skills attention processing speed working memory episodic memory significant societal problem despite enormity issue relatively interventions cognitive aging may due current state knowledge biological factors underpin cognitive aging one biological contributors cognitive aging chronic neuroinflammation review provide overview peripheral central mechanisms involved chronic neuroinflammation neuroinflammation may related age associated cognitive decline plant based extracts including herbal nutritional supplements anti inflammatory properties examined relation utility treating age related cognitive decline plant based extracts particular offer interesting pharmacological properties may quickly utilized prevent cognitive aging
number chronic inflammatory diseases associated ige mediated immunologic hypersensitivity including atopic dermatitis chronic rhinosinusitis asthma pathogenetic studies well characterized patient groups allowed investigators precisely define molecular pathways involved diseases specific cytokines chemokines well unique proteins identified common disorders number medications currently development inhibiting actions continual refinement understanding pathogenesis diseases undoubtedly yield increasingly precise potentially effective treatments
planar graph navigation important problem significant implications point location geometric data structures routing networks however whilst number algorithms existence proofs proposed little analysis available properties paths generated computational resources required generate random distribution hypothesis input paper analyse new deterministic planar navigation algorithm constant spanning ratio euclidean distance follows vertex adjacencies delaunay triangulation call strategy cone walk prove given uniform points smooth convex domain unit area start point query point cone walk applied access vertical bar vertical bar root log sites complexity vertical bar vertical bar root log log log probability tending goes infinity additionally show model cone walk log memoryless high probability pair start query point domain positive take special care throughout ensure bounds valid even query points arbitrarily close border wiley periodicals inc
animals domesticated working closely humans dogs shown remarkable adjusting behaviour human attentional stance however little evidence form information perception species domesticated production rather companionship tested domestic ungulates goats ability differentiate attentional states humans first experiment investigated effect body head orientation one human experimenter approach behaviour goats test subjects significantly changed behaviour experimenter turned back subjects take account head orientation alone second experiment goats could choose approach one two experimenters one paying attention goats preferred approach humans oriented body head towards subject whereas head orientation alone effect choice behaviour third experiment goats transferred separate test arena rewarded approaching two experimenters providing food reward training trials subsequent probe test trials goats choose two experimenters differing attentional states like experiments goats show preference attentive person inattentive person turned head away subject last experiment goats preferred approach attentive person compared person closed eyes covered whole face blind however goats showed preference one person covered eyes results show animals bred production rather companionship show differences approach choice behaviour depending human attentive state however results contrast previous findings regarding use head orientation attribute attention show importance cross validating results
integration new technologies learning process became specific research field last years mainly focused information technologies formerly obsolete learning procedures able catch fast progress professional practice framework engineering curricula frequently accepted new procedures new equipment must presented students soon introduced going activity moreover incorporation innovative procedures advanced equipment daily lessons one purposes research activities carried engineering schools benefits specific learning outcomes students knowledge newest technologies considered important contribution modernize industrial networks consolidation research activities private institutions important aspect countries low technological activity addition approach non traditional education procedures works motivating agent students lecturers incorporation research facilities practical learning promotes expansion enhancement student understanding also optimization lecturers knowledge role learning conductors work proposes application laser assisted raman spectroscopy combined traditional testing methods hands learning activity mechanical engineering materials engineering students fundamentals phenomena presented students means interdisciplinary approach materials science applied continuum mechanics analysis stress strain fields polymer samples different loads experimental determination raman spectrum different points allows students realize capabilities limitations non destructive method comparison experimental methods employment strain gages ray diffraction photoelasticity based method use laser assisted raman spectroscopy constitute step forward learning experimental stress analysis work presents discusses design development practical learning activity assisted research technology
objective determine travel patterns patients undergoing gastrectomy cancer identify factors associated patient decision background support regionalization complex surgery grows however little known willingness patients travel care furthermore utilization outcomes data patients hospital selection processes well understood methods analysis california office statewide health planning development database outcome measures included total distance traveled rate bypassing nearest gastrectomy performing hospitals multivariate analyses identify predictors bypassing local hospitals performed results total study population majority patients underwent gastrectomy nearest providing hospitals distance traveled destination hospitals california averaged miles bypassing patients traveled approximately miles beyond nearest hospitals receive care selecting lower volume destination hospitals cases annual gastrectomy volumes nearest destination hospitals averaged cases respectively inhospital mortality rates respectively patients sought care teaching hospitals rural county residence significantly reduced likelihood bypass cases teaching status destination hospitals predictive hospital bypass though significant association mortality rate bypass identified conclusions majority gastric cancer patients underwent gastrectomy providing hospitals nearest home reflecting little regionalization gastrectomy california patients hospital selection appears driven outcomes data
paper presents technique recognize power quality disturbances associated solar energy penetration distribution network voltage signal analysed help stockwell transform transform features utilized recognize power quality events help fuzzy means clustering fcm operations considered assessment include grid synchronization outage solar photovoltaic system events associated sudden change solar insolation also investigated proposed study carried using standard ieee bus test system modified incorporating solar system effect increase solar energy penetration terms power quality assessment also investigated solar systems capacities using proposed power quality index maximum deviations frequency total harmonics distortions voltage current study carried using matlab simulink simulation results compared real time results obtained using real time digital simulator rtds validating effectiveness proposed study elsevier ltd rights reserved
paper presents smpm multi phase electric drive traction application whole drive motor structure converter structure pwm control strategy proposed particular drive control link advantage multi phase structure investigated specific machine design possibility strongly reduce link capacitor stress presented thanks phase shift pwm carriers different converters comparison analysis given motor wounded supplied three different ways also considering fault conditions
purpose compare prevalence attention deficit hyperactivity disorder adhd children normal vision vision problems correctable glasses contact lenses vision problems determined parent report nationwide telephone survey methods cross sectional study included children without intellectual impairment aged years participating national survey children health conducted centers disease control prevention demographic information information regarding vision adhd status obtained parent interview questions asked whether ever told doctor health care provider child vision problem correctable glasses contact lenses adhd intellectual impairment one common chronic conditions childhood follow question asked condition severity main outcome measure current adhd results prevalence current adhd greater among children vision problems compared normal vision odds adhd compared children normal vision greatest moderate vision problems odds ratio confidence interval mild vision problems children severe vision problems similar odds adhd children normal vision perhaps small numbers group multivariable analysis adjusting confounding variables vision problems remained independently associated current adhd conclusions large nationally representative sample prevalence adhd greater among children vision problems correctable glasses contacts association vision problems adhd remains even adjusting factors known associated adhd
introduction young people eating disorders risk harm social emotional physical development life chances although reluctant seek help may access social media information advice support relationship social media youth well emotive subject clearly understood qualitative study aimed explore young people used youth orientated moderated online eating disorders discussion forum run eating disorders charity methods applied netnographic approach involving downloading thematically analysing messages posted augustnovember results data analysis generated five themes taking role mentor online discussion forum safe space friendship within online forum flexible help peer support recovery relapse prevention forum moderation may influenced forum culture discussion findings consistent literature youth preferences mental health self care support young person decision use discussion forum construed pro active self care moderated online discussion forum make positive contribution support youth eating disorders countering negative media perceptions online groups conclusion study adds knowledge young people access support via social media online discussion forums safe acceptable spaces youth access help research could provide insights impact forum moderation
objective primary objectives compare efficacy extracts plant tribulus terrestris marketed tribestan comparison placebo treatment men erectile dysfunction without hypoactive sexual desire disorder hsdd well monitor safety profile drug secondary objective evaluate level lipids blood treatment participants design phase prospective randomized double blind placebo controlled clinical trial parallel groups study included males aged years mild moderate without hsdd randomized placebo patients hypertension diabetes mellitus metabolic syndrome included study trial herbal medicine intervention bulgarian origin used tribestan sopharma tribestan film coated tablet contains active substance tribulus terrestris herba extractum siccum standardized furostanol saponins less patient received orally film coated tablets daily meals week treatment period end month participants sexual function including assessed international index erectile function iief questionnaire global efficacy question geq several biochemical parameters also determined primary outcome measure change iief score weeks treatment complete randomization random sorting using maximum allowable deviation equal number patients sequence used randomization algorithm restriction unequal treatment allocation allowed groups must target sample size patients investigational staff data collectors blinded treatment outcome assessors also blinded group allocation results patients group completed study iief score improved significantly group compared placebo group intention treat itt statistically significant difference change baseline iief scores difference placebo itt population statistically significant difference placebo found intercourse satisfaction orgasmic function sexual desire overall satisfaction well geqresponses favour oftt differences incidence adverse events aes two groups therapy well tolerated drug related serious aes following week treatment period significant improvement sexual function observed compared placebo men mild moderate generally well tolerated treatment elsevier rights reserved
objectives study describe prescribing practices evaluate appropriateness compliance guidelines examine influencing factors conducted cross sectional study antibiotic prescriptions data patients medical surgical emergency department military hospital instruction mohammed rabat period one month data collected means questionnaire including demographic anamnestic data patient history allergies specific clinical examination data paraclinical data detailed antibiotic prescription collected data evaluated referring physician responsible detecting treatment error among infections requiring prescription antibiotics respiratory urinary system diseases forefront commonly used antibiotic families penicillins quinolones cephalosporins prescriptions pertinent compliant versus prescriptions justified nonpertinent prescriptions considered unjustified referring physician due absence infection evaluation existing medical practice rarely conducted health facilities mind case study aims improve appropriate antibiotic prescribing optimize compliance guidelines
objectives present study examines question activation critical lure alzheimer patients deese roediger mcdermott drm like task precisely older adults alzheimer patients performed lexical decision task asked categorize strings letters words nonwords contrary drm paradigm activation inferred production recall lexical decision task require joint use intentional recovery strategies source monitoring processes known particularly impaired alzheimer patients performance lexical decision therefore reflects activation without contamination strategic processes method twenty nine older adults alzheimer patients performed lexical decision task drm lists intermixed neutral words nonwords results analysis indicated older adults well alzheimer patients showed shorter lexical decision latencies cls types words discussion contrary existing literature results suggest activation preserved alzheimer patients mild moderate stages disease
autoinflammatory diseases caused defects genes regulate innate immunity recently scope autoinflammation broadened include diseases result dysregulations protein modifications highly conserved ubiquitin peptides thus far diseases consist linear ubiquitin chain assembly complex lubac otulin deficiencies haploinsufficiency lubac critical linear ubiquitination key signaling molecules immune response pathways deubiquitinase enzymes otulin tnfaip reverse effects ubiquitination hydrolyzing linear met lys moieties respectively conjugated proteins consequently otulin deficient cells excess met chains nemo ripk target substrates lead constitutive activation kappa pathway mutant cells produce elevated levels many proinflammatory cytokines respond therapy cytokine inhibitors patients impairment lubac stability compromised kappa responses non immune cells fibroblasts monocytes hyperresponsive beta discoveries germline mutations enzymes regulate protein modifications define new category autoinflammatory diseases caused upregulations kappa signaling primary aim review summarize latest developments understanding etiology autoinflammation
kinematic effects head flexible vertical pile embedded two layer soil deposit investigated means rigorous three dimensional elastodynamic finite element analyses pile soil idealized linearly viscoelastic materials modelled solid elements without restrictions associated use strength materials approximations system analyzed time fourier approach conjunction modal expansion space constant viscous damping considered natural mode fft algorithm employed switch frequency time domain vice versa natural generalized coordinates scope paper elucidate role number key phenomena controlling amplitude kinematic bending moments pile head propose simplified semi analytical formula evaluating moments provide remarks role kinematic bending seismic design pile foundations results study provide new interpretation interplay interface kinematic moments corresponding head moments function layer thickness pile soil stiffness ratio stiffness contrast soil layers addition role diameter designing kinematic action without presence inertial counterpart discussed copyright john wiley sons ltd
years since holzman introduced special issue schizophrenia bulletin entitled thought disorder schizophrenia pointed editor introduction contrast explosion interest time biological aspects schizophrenia important areas study represented relatively neglected aspects psychopathology schizophrenia namely varieties thinking disorders emphasis added characteristic schizophrenic patients possible underlying mechanisms perhaps presciently ended introduction expressing hope articles included issue would lead intensive study cognitive emphasis added dysfunctions schizophrenia indeed extensive research conducted understanding cognitive dysfunctions schizophrenia considerably less understanding thought disorder
paper using lab view graphical programming environment made number virtual instruments used demo study low power active filters operational amplifiers amp analyzed active first order low pass high pass band pass filters results included two papers first one contains simulation active filters different values passive components feedback input resistor capacitors around amp selected numerical controls type filter effect seen using bode characteristic frequency response curve filter alternating current frequency characteristic best described term bode plot gain plotted log scale vertical axis frequency plotted log scale horizontal axis amp ideal frequency response curve open loop also displayed chart values open loop gain frequency cut also set numerical control validity program done comparing simulation results data obtained calculation using theory program designed modular manner used successfully education training courses
objective paper study bearing capacity loading behavior strip footings geosynthetically reinforced loose sand laboratory loading tests conducted rigid steel strip footing sand box woven geotextile used reinforcement material finite difference program used simulate load settlement behavior footing two constitutive mohr coulomb double yield models utilized loose sand direct shear tests performed obtain parameters needed numerical simulation unreinforced ultimate bearing capacity obtained study ranges theoretical values calculated assuming general local shear failure conditions bearing capacity predicted two soil models match values obtained sand box tests however double yield model outperforms traditional mohr coulomb model simulating loading behavior strip footing
given importance buildings major consumers resources worldwide several organizations working avidly ensure negative impacts buildings minimized green building council usgbc leadership energy environmental design leed rating system one effort recognize buildings designed achieve superior performance several areas including energy consumption indoor environmental quality paper discusses testing hypotheses examining leed certified buildings arizona state university asu campus tempe two different perspectives macrolevel microlevel heating cooling electricity data collected leed certified buildings campus energy use intensity calculated investigate buildings actual energy performance addition indoor environmental quality occupant satisfaction surveys administered investigate users satisfaction space layout space furniture thermal comfort indoor air quality lighting level acoustic quality water efficiency cleanliness maintenance facilities occupy macrolevel perspective results suggest asu leed certified buildings consume less energy regional counterparts exhibit higher occupant satisfaction national counterparts microlevel perspective results data analysis suggest inconsistency leed points earned energy atmosphere indoor environmental quality categories one hand respective levels energy consumption occupant satisfaction hand accordingly paper showcases variation leed certified buildings assessment results approached different perspectives contribution necessitates consideration complementary macrolevel microlevel assessments tandem ensure fair representative leed certification system authors recommend basing awarded leed points actual performance building occupation phase opposed intended performance design construction stages american society civil engineers
aging may enhance oxidative stress bone marrow mesenchymal stem cell msc differentiation adipocytes reduces osteoblastogenesis thus favoring bone mass loss fracture representing important worldwide health issue mainly countries aging populations intake antioxidant products may help retain bone mass density interestingly novel olive pomace physical treatment generate olive oil also yields products rich functional antioxidants thus diet postmenopausal women supplemented two months one products distillate rich squalene treatment serum women showed reduced lipidic peroxidation oxidized low density lipoprotein ldl besides vitamin coenzyme levels increased furthermore culture medium containing serum increased osteoblastogenesis reduced adipogenesis human msc bone marrow therefore highly antioxidant products like may represent relevant source development functional products prevention treatment degenerative pathologies associated aging like osteoporosis elsevier inc rights reserved
context spirodela polyrhiza schleid lemnaceae spirodelae herba known relieve inflammation urticaria skin symptoms including pruritus eczema rash objective effects extract two calcium ion channels orai trpv potential novel therapeutics atopic dermatitis investigated regulatory role orai mast cell degranulation evaluated materials methods dried leaves extracted methanol effects extract hekt cell line overexpressing human orai trpv assessed ion channel modulation transfected hekt cells measured using conventional whole cell patch clamp technique ige antigen complex stimulated mast cell degranulation measured beta hexosaminidase assay morphological observation treatment extract results extract significantly inhibited orai activity orai stim overexpressed hekt cells extract significantly increased trpv activity compared positive control apb induced full activation extract inhibited degranulation ige antigen complex stimulated rbl mast cells decreasing beta hexosaminidase activity respectively conclusion results suggested extract could treat abnormal skin barrier pathologies modulation activities calcium ion channels orai trpv inhibition mast cell degranulation first report herbal effect modulation ion channels associated skin barrier disruption pathogenesis
building design construction require collective effort diverse project participants coordination performance project participants important effective management needs assessed periodically however uncomplicated quantitative way measure coordination measuring coordination cumbersome time consuming particularly project execution phase study proposes easy procedure monitoring coordinative performance project participants degree betweenness closeness centrality measures project participants wayfinding signage project major airport construction project calculated using social network analysis mail communication network participants centrality index defined firm based average three centrality measures firm coordination score also calculated based content analysis sent received mails participants coordination scores found highly correlated centrality indices define coordinative role firm centrality index could therefore measured easily using simple software number direction mails exchanged participants rather performing cumbersome time consuming content analysis exchanges calculate coordination scores
racially motivated hate crimes non criminal bias incidents general forms crime associated structural factors social disorganization powerful structural correlate general crime predict rates hate incidents however tests social disorganization effects racially motivated hate crime yield inconsistent results study uses data pennsylvania human relations commission phrc explore inconsistencies specifically assess effects social disorganization across contexts types bias motivation using bias incidents years results suggest social disorganization particularly residential instability robustly correlated rates hate crime prejudicial conduct interactive effects social disorganization help explain variations incident rates motivation type specifically anti black incidents frequent unstable homogeneous white advantaged communities anti white incidents frequent unstable disadvantaged communities
based inspection tools generally implement probes hypervisor monitor events state kernel guest system important function probe carve information interest memory guest triggered implementing probes closed source demands manually reverse engineering undocumented code data structures kernel binary image furthermore reverse engineering result often non reusable versions even kernel updates due rapid change structures paper propose probebuilder system automating process inference kernel data structures based dynamic execution probebuilder searches data structures matching pointer offset pointer pattern guest memory sequences offsets referred dereferences verified probebuilder instruction evidence traverse experiment windows kernel shows probebuilder efficiently narrows thousands choices kernel level probes dozens finding allows analysts quickly implement probes facilitating rapid development update inspection tools different oses features probebuilder first system capable automatically generating practical probes extracts information dereferences opaque kernel data structures
background genome wide association studies identified orm yeast like protein isoform ormdl gene locus human chromosome highly significant risk factor childhood onset asthma objective sought investigate vivo functional role ormdl disease inception methods ormdl deficientmousewas generated andthe role ormdl generation allergic airways disease fungal aeroallergen alternaria alternata determined adenoassociated viral vector also used reconstitute ormdl expression airway epithelial cells ormdl knockout mice results ormdl knockout mice found protected developing allergic airways disease showed marked decrease pathophysiology including lung function airway eosinophilia induced alternaria alternaria potent inducer cellular stress unfolded protein response ormdl found play critical role driving activating transcription factor mediated arm response xbp downstream activation endoplasmic reticulum associated degradation pathway addition ormdl mediated uric acid release another marker cellular stress knockout mice reconstitution ormdl transcript levels specifically bronchial epithelium resulted reinstatement susceptibility fungal allergen induced allergic airways disease conclusions study demonstrates ormdl asthma susceptibility gene identified genome wide association studies contributes key pathways promote changes airway physiology allergic immune responses
despite improved understanding disease biology use multi agent chemotherapy long term survival adults cell acute lymphoblastic leukemia ranges management patients relapsed group characterized dismal outcomes poses clinical challenge address unmet need novel therapeutics investigated setting relapsed encouraging results important cell antigen expressed cases undergoes constitutive endocytosis antibody ligation making attractive biologic target immunoconjugates inotuzumab ozogamicin targeted antibody drug conjugate demonstrated impressive single agent activity even among heavily pretreated relapsed patients recent randomized phase iii clinical trial demonstrates superiority standard care chemotherapy first second line salvage therapy relapsed review summarize preclinical clinical data available date using relapsed
study investigated various risk protective factors interface child health well population level specifically examined association income social contextual variables indicators health related habits activities children life satisfaction perceived overall health child data collected via self report survey middle years development instrument administered three demographically diverse canadian school districts grade students students complete data included analyses multiple regression mediation analyses conducted examine joint associations social relationships adults peers nutrition sleep habits school sports activities children satisfaction life perceived health results indicate peer belonging relationships adults home school strongest predictors life satisfaction furthermore small association income life satisfaction mediated social relationship variables child reports perceived health predicted peer belonging adult relationships home school neighborhood school team sports nutrition habits small association income health mediated social relationships team sports participation findings discussed light previous research social determinants socio economic gradients children health life satisfaction
focus succinct data structures time space efficient representations trees combinatorial objects dominate memory requirements sophisticated programs systems
article describes accurate steady state analysis stand alone phase self excited induction generator seig analysis based newton raphson algorithm shown system performance greatly affected parameters related availability primary energy load variations excitation capacitor values parameters explain stator voltage fluctuations output frequency decrease avoid interruption excitation process ensure good quality stand alone minigrid three phase voltage regulator tpvr based switched capacitors proposed keep terminal seig voltage constant control algorithm regulation process implemented using microcontroller seig tpvr experimentally developed variable capacitor bank constructed experimental investigations induction machine confirm efficiency whole suggested system
background term cluster tic syndrome used rare ipsilateral occurrence attacks cluster headache trigeminal neuralgia medical treatment combine treatment cluster headache trigeminal neuralgia often unsatisfactory case describe year old woman diagnosed cluster tic syndrome underwent microvascular decompression trigeminal nerve primarily aimed trigeminal neuralgia part pain syndrome venous decompression trigeminal nerve decrease trigeminal neuralgia cluster headache attacks seen however headache disappear completely furthermore reported decrease pain intensity remaining cluster headache attacks discussion case description suggests venous vascular decompression cluster tic syndrome remarkably effective trigeminal neuralgia cluster headache
olive tree traditional plant fruits olea europaea used olive oil production especially mediterranean countries olive oil extraction produces products become major environmental issue recently studies carried residues regarding phytochemical identification biological toxicological evaluation bioactive compounds contained products high antioxidant activity especially oleuropein characteristic fatty acids profile interesting mineral composition indeed taking account composition sustainability issues reuse disposal residues advisable agro industrial products potential used different purposes providing economical advantage particular field skin care products cosmetics may benefit remaining materials bioactive compounds fulfill real cosmetic function activity review presents composition different olive products bioactive compounds possible application wastes cosmetic ingredients critically reviewed elsevier rights reserved
political debate adolescents access emergency contraception available counter going years since levonorgestrel plan one step used united states emergency contraception prescription time fda done years research testing barr laboratories manufacture plan one step make safe females ages fda recommended counter use plan one step ages yet occur pharmacies across nation young women find impossible purchase product whether age politics making choices young females medical evidence long going let continue
communicative act involves presence two persons always involves nonverbal aspect focus article nonverbal situations basis evolution belief narratives pre narrative aspect received much attention narrative research analyses based texts already exist verbalised form however many occasions basis belief narrative nonverbal act triggered witness narrator interpret within framework vernacular belief hence texts contain nonverbal part consist two components description nonverbal occurrence meaning interpretation verbalised narrator within framework topical belief tradition bringing examples estonian belief narratives author points models patterns leap eye texts narrating nonverbal occurrences context described situations types results activities described etc theoretical basis works communication theory vernacular belief research used
crime victims may respond emotionally victimization multitude ways however little known people use victims emotional expressions draw inferences psychological status needs two experiments total participants presented victim reacted crime either anger sadness additionally victim gender experiment presentation modality text video audio experiment manipulated male female victims perceived stronger need social support expressing sadness opposed anger effect mediated fact victims expressing sadness anger perceived warmer moreover effect consistent across presentation modalities results show victim gender differences distinct emotions need taken account understand social consequences victims emotional expressions
camera trapping widely applied method study mammalian biodiversity still gaining popularity quickly generate large amounts data need managed efficient transparent way links data acquisition analytical tools describe free open source package camtrapr new toolbox flexible efficient management data generated camera trap based wildlife studies package implements complete workflow processing camera trapping data assists image organization species individual identification data extraction images tabulation visualization results export data subsequent analyses limitation number images stored data management system system portable compatible across operating systems functions provide extensive automation minimize data entry mistakes apart species individual identification require minimal manual user input species individual identification performed outside environment either via tags assigned dedicated image management software moving images species directories input occupancy spatial capture recapture analyses density abundance estimation example packages unmarked secr computed flexible reproducible manner addition survey summary reports generated spatial distributions records plotted exported gis software single two species activity patterns visualized camtrapr allows streamlined flexible camera trap data management useful researchers practitioners regularly handle large amounts camera trapping data
technical brief problem estimation remote signal generated discrete time dynamical system periodic coefficients subject multiplicative additive white noise perturbations investigated measure quality estimation achieved admissible filter introduced performance criterion described cesaro limit mean square deviation estimated signal remote signal dimension state space admissible filters prefixed state space representation optimal filter constructed based unique periodic solution discrete time linear equation together stabilizing solution suitable discrete time riccati equation periodic coefficients
objective reports show disparities health care persons severe mental illness smi including countries universal health insurance however moderating effect disparities specific mental health legislation yet studied study aimed investigate equality health care people smi country national health insurance comprehensive rehabilitation law persons mental disabilities method case control epidemiological study compared health services laboratory tests visits specialists medications provided users without history schizophrenia bipolar disorder regard subgroup users diabetes addition examined mortality rates study population results service users schizophrenia somewhat less likely meet indexes care controls bipolar disorder differ counterparts yet mortality risk among service users schizophrenia bipolar disorder times higher respectively rates services persons smi comorbid diabetes differ counterparts conclusions israel country national health insurance rehabilitation law persons mental disabilities service users bipolar disorder receive equitable levels general health care users schizophrenia disparities exist health care measures smaller extent countries universal health insurance contrast mortality rates elevated persons smi
stinging nettle urtica dioica medicinal herb commonly used humans role reactive oxygen metabolites cancer etiology known studies antioxidant effects urtica dioica therapy cancer types study aimed investigate effects antioxidant enzyme activities mammary gland cancer induced rats methyl nitrosourea nmu carcinogenesis rats divided four groups untreated group group nmu group group given nmu intraperitoneal injection nmu group group treated control group group fed months rats decapitated mammary tissue blood samples obtained significant respectively increase plasma malondialdehyde mda levels group compared group superoxide dismutase sod activity erythrocytes decreased group groups erythrocyte catalase cat activity significantly increased group compared group respectively number animals palpable tumors group group end week although group lower palpable tumor number group difference statistically significant results showed constituents may effects lipid peroxidation antioxidant enzyme activities may slow formation mammary tumor
purpose purpose paper improve manufacturing prosthetic acetabular shell analyzing main factors leading failure selective laser melting slm additive manufacturing process design methodology approach different computer aided design computer aided manufacturing processes applied fabricate acetabular parts various investigations surface quality mechanical properties microstructure carried scrutinize possible limitations fabrication findings geometrical measurements showed per cent differences designed manufactured prototypes inside outside diameter respectively however resulting studies showed unstable surfaces cracks interruption powder delivery low surface quality main problems occurred process results indicate slm accurate promising method production intricate shapes provided appropriate settings production conditions considered minimize possible limitations originality value contributions paper discussions covering different issues fabrication acetabular shells improve mechanical properties quality durability produced parts
mobility management become core function internet services networks mobile devices widely used capabilities dramatically advanced expected proxy mobile ipv pmipv prominent solution play important role supporting devices mobility protect pmipv networks several authentication schemes presented however due static approach existing schemes failed keep good balance security efficiency motivated authors study adaptive authentication scheme mobile devices pmipv networks particular proposed scheme considers mobile nodes context information decide authentication strength based adaptive authentication performed shown formal security verification example study proposed scheme correct also achieves good trade security efficiency
covering common form data representation covering based rough sets technique granular computing provide effective tool deal type data however many important problems covering based rough sets covering reduction hard algorithms solve greedy ones matroid theory based linear algebra graph theory provides well established platforms greedy algorithms lattice widely used diverse fields especially algorithm design plays important role covering reduction therefore necessary integrate covering based rough sets matroid lattice paper construct three types matroids covering based rough sets investigate modularity moreover investigate characteristics types closed set lattices induced three types matroids relationships among closed set lattices first based covering based rough sets three families sets constructed proved satisfy independent set axiom matroids three types matroids induced covering based rough sets way second characteristics matroids rank function closure operator closed set presented moreover investigate characteristics closed set lattices induced three types matroids modular pair modular element finally relationships among closed set lattices induced three types matroids investigated especially prove three types matroids induced covering based rough sets modular matroids
inflammatory bowel disease irritable bowel syndrome chronic gastrointestinal disorders associated lifelong therapeutic need disease results physical psychological social problems impact partnership sexuality education career thus number patients health care professionals relying traditional complementary medicines especially phytotherapy treatment chronic conditions increasing recent years one traditional herbal medicinal product consisting chamomile flower myrrh coffee charcoal widely used clinical practice within indication area long term experience increasing understanding pharmacological mechanisms substantiate application clinical effectiveness mainly spasmolytic anti inflammatory effects provide rationale therapeutic application addition synergistic effects herbal components contribute overall effect medication
development damage identification methods enable rapid implementation holds great promise assessing structural integrity avoid damage catastrophic failure line model updating approach proposed rapidly simultaneously identify mass stiffness damping properties structural model proposed approach facilitates identification unknown parameters using two steps first energy equilibrium equations used establish relationship structural energy unknown parameters second kalman filter adopted obtain unknown parameters short period time numerical verification conducted degree freedom truss model unknown parameters based real world structure results indicate proposed approach simultaneously identify model parameters mass stiffness damping damaged undamaged structures online also effectively identify stiffness damage mass change even environment noise copyright john wiley sons ltd
humans two splice variants glucocorticoid receptor exist canonical isoform beta isoform shown dominant negative effect hgr alpha previously established occurrence beta isoform zebrafish present study investigated functional role zebrafish beta zgr beta reporter assays cos cells demonstrated dominant negative effect zgr beta effect observed zebrafish pac cells using induction binding protein fkbp gene readout subsequently generated transgenic fish line inducible expression zgr beta transcriptome analysis suggested transcriptional regulation genes zgr beta line validation failed confirm role based results low expression level poor evolutionary conservation suggest zebrafish beta isoform functional role transcriptional regulation elsevier rights reserved
modelling multi million atomic semiconductor structures important predicts properties physically realizable novel materials accelerate advanced device designs work elaborates new technology computer aided design tcad tool nanoelectronics modelling uses tight binding approach describe multi million atomic structures simulate electronic structures high performance computing hpc including atomic effects alloy dopant disorders named quantum simulation tool advanced nanoscale devices tool shows nice scalability traditional multi core hpc clusters implying strong capability large scale electronic structure simulations particularly remarkable performance enhancement latest clusters intel xeon phi coprocessors review recent modelling study conducted understand experimental work highly phosphorus doped silicon nanowires presented demonstrate utility developed via intel parallel computing center project open public establish sound framework nanoelectronics modelling advanced hpc clusters many core base details development methodology exemplary study dopant electronics work present practical guideline tcad development researchers field computational nanoelectronics author published elsevier open access article license
wearable heaters increasingly attracting researchers great interest due efficient utility maintaining warmth thermotherapy nowadays carbon nanomaterials metallic nanowires tend become mainstream heating elements wearable heaters considering excellent electrical mechanical properties though considerable progress made still exist challenging issues need addressed practical applications including bad breathability poor endurance mechanical deformations devise copper nanowire based composite fiber unique hierarchical structure fiber possesses excellent heating performance also fantastic tolerance mechanical impact bending twisting stretching weave fibers wearable heating fabric realize smart personal heating management android phone integrating microcontroller unit two practical applications demonstrated including heating kneepad articular thermotherapy heating coat infant model maintaining warmth
today high technological world scientific discoveries contribute remarkable development human life could also adverse impact mankind among advancements media one inventions aims capturing countless group viewers transmit information via various mediums media violence considered one hampering determinants harms individual psychologically primary goal health professional work maintenance mental health therefore imperative create understanding impact media violence mental health particularly pakistani context violence become major public health problem pakistan main cause violence seems anger frustration due poverty political conflicts lack education overall governance approach country therefore prime need think work neglected area like conducting research increasing public awareness curb media violence
despite popularity javascript client side web applications lack effective software tools supporting javascript development testing dynamic characteristics javascript pose software engineering challenges program understanding security one important feature javascript objects support flexible mechanisms property changes runtime prototype based inheritance making difficult reason object behavior performed empirical study real javascript applications understand dynamic behavior javascript objects present metrics measure behavior javascript objects execution operations associated object object size property type changes also investigated behavioral patterns observed objects understand coding user interaction practices javascript software copyright john wiley sons ltd
application best estimate codes coupled neutron kinetics thermal hydraulics safety analyses research reactors rrs gained considerable momentum past decade application codes largely facilitated high level technological maturity expertise codes allow safety technology nuclear power plants largely driven international atomic energy agency activities present study belongs framework presents development application coupled code thermo analysis protected reactivity insertion accidents loss flow accidents typical standard materials testing reactor plate type fuel elements coupling realized considering neutronic reactivity feedbacks fuel coolant temperatures heat generation model reactor power neutron flux reactor core solved applying point reactor kinetic equations employing radial axial power distributions calculated three dimensional full core model continuous energy monte carlo reactor physics code serpent evolution temporal spatial distributions fuel cladding coolant temperatures calculated fuel channels using finite volume time implicit numerical scheme solving three conservation equation model study additional features critical heat flux ratio prediction decay heat model implemented highly enriched uranium low enriched uranium cores comprehensive comparison thermo results performed codes
planar ads black holes axionic charge finite conductivity due momentum relaxation obtain new family exact asymptotically ads black branes scalar hair carrying magnetic axion charge study thermodynamics dynamic stability well number previously known electric dyonic solutions axion charge scalar hair scalar hair solutions satisfy mixed boundary conditions lead modified holographic ward identities conserved charges free energy relative following standard dirichlet boundary conditions show properly accounting scalar boundary conditions leads well defined first law thermodynamic relations finally compute holographic quantum effective potential dual scalar operator show dynamical stability hairy black branes equivalent positivity energy density
remains incompletely understood whether association transcriptome profiles skeletal muscle blood leukocytes response exercise physiological stressors previously analyzed changes muscle blood neutrophil transcriptome eight trained men cycling running collected muscle blood individuals conditions able directly compare gene expression muscle blood neutrophils applying weighted gene coexpression network analysis wgcna advanced network driven method original data sets enabled compare muscle neutrophil transcriptomes rigorous systematic manner two gene networks identified preserved skeletal muscle blood neutrophils functionally related mitochondria posttranslational processes strong preservation measures summary muscle neutrophil gene networks evident within postexercise recovery period muscle neutrophil gene coexpression strongly correlated mitochondria related network also identified multiple correlations muscular gene subnetworks exercise induced changes blood leukocyte counts inflammation muscle damage markers data reveal previously unidentified gene coexpression skeletal muscle blood neutrophils following exercise showing value wgcna understand exercise physiology furthermore findings provide preliminary evidence support notion blood neutrophil gene networks may potentially help track physiological pathophysiological changes muscle new noteworthy using weighted gene coexpression network analysis advanced bioinformatics method identified previously unknown functional gene networks preserved skeletal muscle blood neutrophils recovery exercise novel preliminary data suggest muscular gene networks coexpressed blood leukocytes following physiological stress step forward toward development blood neutrophil gene subnetworks part blood biomarker panels assess muscle health disease
argued article develop richer models effective pedagogical tools studies exploring relationship mass media young people need foreground media use context young peoples daily lives well context broad social political issues shape specific media forms constructed deployed taken young people focusing primarily major trends media effects tradition dominant paradigm among social scientists article surveys assesses four key themes effects research concerning adolescents heavy media consumption media violence sexuality media young women recent research developments concerning young people new digital media forms also considered arguments media youth culture apolitical economy perspective reviewed briefly
fruit leaves junipers commonly used internally tea pounded fruits eaten lower blood glucose levels anatolia thus aimed evaluate antidiabetic antioxidant potential chemical profile juniperus foetidissima willd sabina study vitro antidiabetic activities leaf fruit extracts examined inhibitory activity glucosidase amylase enzymes vivo antidiabetic activities leaf fruit extracts juniperus species investigated streptozotocininduced diabetic rats additionally antioxidant activities phosphomolybdenum ferric reducing antioxidant power abts radical scavenging activity assays phytochemical screening tests high performance liquid chromatography analysis hplc done vitro enzyme inhibitory effects extracts supported results vivo antidiabetic activity studies phytochemical screening tests indicated presence flavonoids tannins terpenoids carbohydrates extracts amentoflavone identified major compound extracts content amentoflavone determined result juniperus extracts active constituents might beneficial diabetes complications
introduction antimuscarinics used caution older adults overactive bladder oab due anticholinergic adverse events aes systematic reviews meta analyses srmas analyzed safety related outcomes specified risk elderly population highest risk aes aim review explore evaluate aes treatment discontinuations adults older taking antimuscarinics oab methods keywords searched medline embase scopus cochrane central register controlled trials randomized controlled trials rcts along sub analyses pooled analyses compared antimuscarinics placebo another antimuscarinic performed february studies assessing aes treatment discontinuations population adults older included jadad criteria mcharm tool used assess quality trials results total studies met inclusion criteria eighty aes reasons treatment discontinuation described included studies explored anticholinergic aes common antimuscarinics compared placebo incidence dizziness dyspepsia urinary retention fesoterodine headache darifenacin urinary tract infections solifenacin significantly higher compared placebo treatment discontinuation due aes dry mouth higher antimuscarinics compared placebo older adults conclusions treatment overactive bladder using antimuscarinics adults aged older resulted significant increases risk several aes compared placebo including anticholinergic non anticholinergic aes elsevier ireland ltd rights reserved
recent studies revealed memory enhanced information processed fitness related purposes main objective current experiments test developmental trends evolutionary foundation memory using different types stimuli paradigms experiment year olds adults presented neutral negative survival related drm word lists found memory benefit survival related words showed false memories likely elicited survival related word lists lists experiment examined developmental trends survival processing paradigm using neutral negative survival related pictures survival processing advantage found survival related pictures adults negative pictures year olds neutral pictures year olds experiment year olds adults imagine standard survival scenario adapted survival condition pleasantness condition designed reduce possibilities elaborative processing found superior memory retention survival scenarios children adults collectively results evidently show survival processing advantage developmentally invariant certain proximate mechanisms elaboration distinctiveness underlie developmental trends
carleton university rotorcraft research group working development active rotor control system incorporates mechanism helicopter blade pitch dynamic stiffness modulation root active pitch link system overcomes stroke limitations smart material attains superior performance helicopter rotor induced vibration reduction system tested whirl tower facility article reports achievements obtained dynamically similar hinged rotor blade model reduction transmitted loads occurred target rev frequency blade excited transversal jet mimic asymmetric flow helicopter rotor forward flight open loop control algorithm optimized target higher harmonic frequency rotor also minimized impact rotor fundamental cyclic control frequency rev another experiment university sao paulo semi passive control techniques using shunted piezoelectric materials investigated aeroelastic control fixed wings flutter oscillations typical section controlled range airflow speeds finally similarity control techniques discussed recognized based dynamic stiffness modulation control principle
leader follower formation control unmanned vehicles presence limited sensing communication studied assumed follower equipped onboard tracker measure relative kinematic parameters respect leader considering practical measurements obtained onboard tracker state space representation leader follower system obtained employing state feedback controller relative angle relative range regulated desired values modeling tracker mechanism effect tracker dynamics sensor measurement noise formation keeping studied simulation results verify effectiveness proposed leader follower formation control structure
background responsiveness measurement instrument important understanding ability detect changes progression disease examined compared internal external responsiveness item short form health survey item parkinson disease questionnaire pdq patients parkinson disease methods seventy four patients evaluated using pdq baseline one year addition motor signs motor difficulties daily living depressive symptoms assessed external criteria internal responsiveness examined using effect size standardized response mean wilcoxon signed rank test external responsiveness examined using receiver operating characteristic curves correlation analyses regression models results instruments partially sensitive changes year follow able discriminate patients improved versus deteriorated motor signs addition similarly responsive changes motor difficulties daily living appeared sensitive pdq changes depressive symptoms conclusions pdq acceptably internally externally responsive year follow
backgroundif people recognize posttraumatic stress disorder ptsd symptoms may realize suffering disorder likewise people know effective treatments exist may unlikely seek care study examined people ptsd symptoms know ptsd treatment hypothesized military service prior receipt ptsd treatment would associated greater ptsd knowledge methodswe conducted online survey assessing knowledge three domains trauma ptsd symptoms effective ptsd treatments participants adults veterans drawn national research panel screened positive ptsd resultswhen asked identify items list participants better recognition traumatic events items correct ptsd symptoms effective ptsd treatments across domains participants often identified false items true participants thought divorce trauma could cause ptsd drug addiction ptsd symptom support groups effective ptsd treatments prior receipt ptsd treatment associated better symptom recognition military veteran associated better trauma recognition poorer treatment recognition conclusionspeople ptsd symptoms lack knowledge disorder especially regarding effective treatments public education ptsd needed people recognize seek care treatments choose
background exhaled breath temperature ebt new noninvasive method study inflammatory respiratory diseases potential reach clinical practice however studies available regarding validation method mainly derived small pediatric populations thus range normal values well established aim study measure ebt values italian population subjects mean age years male subjects fev fvc selected adult volunteers define reference values healthy subjects analyze influence individual external variables parameter methods ebt measured halo pro device different ambient temperature ranging degrees degrees results report reference values ebt healthy white subjects never smoked ebt values strongly influenced external temperature lesser extent according sex conclusions large population healthy subjects never smoked data provide reference values measuring ebt basis future studies results contribute promotion ebt bench bedside
electrical networks power transmission practically deals bulk transfer electrical energy generating stations situated many kilometers away main consumption centers cities reason long distance transmission cables utmost necessity effective power transfer evidently results huge losses across system reliable electrical network one transports energy minimal power losses losses corona effect represent one causes hinder reaching performance lines either permanent mode transient mode paper present phenomenon corona behavior different climatic atmospheric conditions rain humidity dust sand dry weather one part voltages induced strokes lightning deal paper influence corona different conditions power losses power lines proposal new model three phase line transient corona
solid state drives ssds extensively deployed cache hard disk based storage systems ssd based cache generally supplies ultra large capacity whereas managing large cache introduces excessive memory overhead turn makes ssd based cache neither cost effective energy efficient work targets reduce memory overhead introduced replacement policy ssd based cache traditionally data structures involved cache replacement policy reside main memory memory data structures suitable ssd based cache since cache much larger ever propose memory efficient framework keeps data structures ssd leaving memory efficient data structure new bloom proposed work main memory framework used implement lru based replacement policies negligible memory overhead evaluate proposals via theoretical analysis prototype implementation experimental results demonstrate framework practical implement replacement policies large caches able reduce memory overhead
objectives helicobacter pylori infection acquired early childhood yet role children health still fully clear narrative review focused association pylori infection children growth methods literature search ovid medline till june embase till august databases performed using terms helicobacter pylori growth body height growth disorders child development original studies addressed association pylori infection eradication children growth reviewed risk bias study assessed results existing evidence based observational studies suggests pylori infection may adversely influence children growth findings consistent across studies low risk bias regarding linear growth observational studies repeatedly linked pylori infection slower diminished linear growth yet known whether association causal association pylori infection ponderal growth less consistent scarce evidence exists effect pylori eradication children skeletal growth weight gain indication pylori eradication may benefit nutritional status conclusions pylori infection may impair children growth additional studies especially clinical trials needed elucidate role pylori eradication children growth mechanisms may involved
develop responsive hydrogels isopropylacrylamide nipam grafted chitosan free radical initiation method using azoisobutrylnitrile aibn initiator optimum grafting conditions worked grafting nipam onto chitosan varying one reaction parameter time keeping parameters constant binary monomers grafted five different concentrations comonomers acrylic acid aac acrylamide aam acrylonitrile optimum grafting conditions evaluated gma alone onto chitosan grafted copolymers analyzed ftir tga dta xrd sem swelling studies grafted samples performed various order explore end use sorption ions water system metal ion sorption behaviour polymeric samples studied function time temperature various metal ion sorption parameters percent uptake partition coefficient retention capacity discussed chitosan grafted binary monomers nipam aac nipam aam showed best results sorption three metal ions elsevier rights reserved
molecular modeling electrical double layer edl structure electrosorption ions pores predicts set competitive entropic energetic effects electrosorption capacity mainly determined size exclusion effects rather applied electrical potential classical edl theory predict effects although size exclusion effects used explain discrepancies experimental observations classical edl theory direct experimental validation molecular modeling predictions yet achieved main objective present work devise test model system used experimentally measure size exclusion effects future validation molecular simulations work first attempt bridge gap molecular modeling predictions edl structure experimentally measured macroscopic properties edl highly uniform titanium dioxide nanotubes three pore sizes used model electrodes study interactive effects pore diameter applied potential ion size electrosorption three monovalent alkaline metal cations proportionality edl electrical capacitance ion electrosorption capacity surface area applied potential predicted classical edl theory hold combinations pore sizes applied potentials examined work electrosorption capacity clearly depended pore diameter rather specific surface area hydrated ion radius measured electrosorption capacity trend cases corresponded trend follows hydrated radius size size exclusion effects edl capacitance electrosorption capacity triggered hydrated ion size pore diameter observed work qualitative agreement molecular modeling predictions elsevier ltd rights reserved
development digital information technologies robust watermarking framework taken real consideration challenging issue area image processing due large applicabilities utilities number academic real environments wide range solutions provide image watermarking frameworks one attempted address efficient applicable idea reality traditional techniques sufficient merit realize accurate application due fact main idea behind approach organized based contourlet representation state art materials investigated along integration aforementioned contourlet representation line watermarking framework concentrated able propose novel skilled technique word main process proposed robust watermarking framework organized deal new embedding embedding processes area contourlet transform generate watermarked image corresponding extracted logo image high accuracy fact motivation approach suggested complexity novelty consists contourlet representation embedding corresponding embedding modules performance monitoring including analysis watermarked image well extracted logo image also scrambling module working association levels directions decomposition contourlet embedding mechanism decision maker system designed deal appropriate number sub bands embedded presence series simulated attacks required performance tangibly considered integration peak signal noise ratio structural similarity indices related watermarked image bit error rate normal correlation considered related extracted logo analysis well subsequently outcomes fully analyzed competitive respect potential techniques image colour models including hue tint terms shade saturation amount gray brightness via value luminance also hue saturation intensity representations long performance whole channels concentrated presented performance monitoring outcomes indicate proposed framework significance verified
backgroundwe sought determine relationship childhood eczema climate environmental pollutants methodswe analyzed data national survey children health including representative sample children age years environmental protection agency measurements carbon monoxide nitrate nitrogen dioxide organic carbon sulfate sulfur dioxide particulate matter tropospheric ozone levels national climate data center measurements relative humidity issued index outdoor air temperature precipitation levels resultsin multivariate survey logistic regression models controlling age sex race ethnicity household income birthplace history moving new location eczema associated higher mean annual arsenic nickel lead vanadium zinc lower cadmium copper potassium contrast moderate severe eczema associated higher copper lead zinc lower principal component analysis used identified combinations pollutants climate factors occurring usa associated higher prevalence two associated lower prevalences eczema conclusionspollutants conjunction climate factors may differentially impact eczema prevalence severity apparent harmful effects
large urban jails become collection point many persons severe mental illness connections jail community mental health services needed assure jail care promote successful community living following release paper addresses issue individuals severe mental illness received community mental health services prior jail detention king county seattle washington year time period using unique linked administrative data source logistic regression used determine probability detainee severe mental illness received mental health services jail function demographic clinical characteristics overall persons severe mental illness receive jail mental health treatment small statistically significant sex race differences observed received treatment jail psychiatric unit jail infirmary findings confirm jail central role mental health treatment emphasize need greater information sharing collaboration community mental health agencies minimize jail use facilitate successful community reentry detainees severe mental illness
aims determine prevalence glucocorticoid use adults diabetes whether prevalence associated reduced skeletal health measured fracture history bisphosphonate use methods participants age years cross sectional national health nutrition examination survey diabetes determined self report fasting plasma glucose mmol alc mmol mol prevalences fractures bisphosphonate use determined diabetes status glucocorticoid use logistic regression stratified sex assessed effect glucocorticoid use diabetes associated fractures bisphosphonates results age standardized prevalence glucocorticoid use higher among persons diabetes without diabetes among adults diabetes prevalence fractures significantly higher among taking glucocorticoids prevalences fractures bisphosphonate use generally similar without diabetes stratified glucocorticoid use logistic regression analysis among men combination diabetes glucocorticoid use compared neither highly associated bisphosphonate use adjusting demographic factors among women diabetes glucocorticoid use increased odds fractures adjusting demographic factors menopause conclusions prevalence fractures greater diabetes taking glucocorticoids versus taking glucocorticoids study provides national framework research elucidating associations elsevier inc rights reserved
current study focuses maternal cognitive capacities determinants parenting highly disadvantaged global context children experiences home often opportunity learning intellectual growth large sample biological mothers preschoolaged children rural pakistan examined unique association maternal working memory skills independent related cognitive capacities cognitively stimulating parenting behaviors path analysis revealed directly assessed working memory short term memory verbal intelligence independently predicted greater levels observed maternal scaffolding behaviors mothers poorer families demonstrated lower levels working memory short term memory verbal intelligence however mothers participation early childhood parenting intervention ended years prior study contributed greater levels working memory skills verbal intelligence domains maternal cognitive capacity mediated effect family economic resources maternal scaffolding verbal intelligence also mediated effect early parenting intervention exposure maternal scaffolding study demonstrates unique relevance maternal working memory scaffolding behaviors required continuously monitoring child engagement providing assistance minimizing external distractions results highlight importance directly targeting maternal cognitive capacities poor women little formal education using generation intervention approach includes activities known promote parental executive functioning literacy
applying observable delay game framework developed noncooperative game theory investigate timing problem concerning manufacturer managing dual channel supply chains consisting retail channel direct channel post wholesale price direct price conventionally operational research models describing dual channel supply chains examine price competition retailer manufacturer simultaneously determine retail direct prices respectively contrast conventional setting model demonstrates simultaneous price competition never arises manufacturer retailer choose level price also timing pricing manufacturer sets direct price setting wholesale price retailer retailer accelerates timing retail pricing prior direct price setting manufacturer findings suggest manufacturer post direct price upon setting wholesale price retailer upfront posting direct price constitutes subgame perfect nash equilibrium noncooperative game channel members also maximizes profits manufacturer employing multichannel sales strategies authors published elsevier
paper theoretical experimental analysis polarimetric synthetic aperture radar sar architectures undertaken sea oil slick observation purposes reference made conventional full polarimetric sar contrasted new generation polarimetric sar architectures known compact polarimetric sar two modes considered hybrid polarity modes whose measurements emulated actual band sar data polarimetric sea surface scattering predicted according extended version bragg scattering model bragg order point differences exhibited sar architectures among sar modes theoretical predictions contrasted experiments undertaken actual polarimetric sar data collected well known oil slicks weak damping surfactants results confirm model prediction showing differences mainly apply polarimetric features estimated slick free sea surface using different sar architectures mode behaving closer sar although sar architectures measure subset information content represent interesting operational alternative detecting oil slicks discriminating weak damping surfactants
article describes development fundamentals machine elements assemblies design processes automation using artificial intelligence descriptions structural elements features natural language realization processes conditions uncertainty non repeatable processes aim research develop basis new design processes higher level automation object approach problems application voice communication design engineer data processing systems proposed interactive automated design systems computational artificial intelligence methods allow communication speech handwriting resulting analyses design engineer messages analyses constructions encoding assessments constructions cad system controlling visualizations system equipped several adaptive intelligent layers human biometric identification recognition speech handwriting recognition words analyses recognition messages enabling interpretation messages assessments human reactions
paper presents robotic system called multifunctional robotic crawler cable inspection developed inspection hanger cables suspension bridges robot move hanger cables perform inspections instruments cameras non destructive testing tools etc novel mechanisms robotic system proposed consideration environmental conditions suspension bridges driving mechanism adopts crawler type one driven brushless direct current motors detachable adhesion tool ensures simple quick installation procedures safe landing mechanism emergency situations guarantees retrieval robot preserving safety operators paper presents robot system field test results super long span suspension bridge called yeong jong grand bridge south korea practical applications real environmental conditions suspension bridge fields robot applied discussed
percutaneous image guided tumor ablation minimally invasive surgical procedure treatment malignant tumors using needle shaped ablation probe automating insertion needle using robot could increase accuracy decrease execution time procedure extracting needle tip position ultrasound images paramount importance verifying needle approaching forbidden regions major vessels ribs could also used direct feedback signal robot inserting needle method estimating needle tip previously developed combining modified hough transform image filters machine learning paper improves method introducing dynamic selection region interest images filtering tracking results using either kalman filter particle filter experiments biopsy needle inserted phantom robot conducted guided infrared tracking system proposed method accurately evaluated comparing estimations needle tip positions manually detected physician images results show significant improvement precision reduction percentile error compared previous automatic approaches method runs real time frame rate frames increased robustness accuracy make algorithm usable autonomous surgical systems needle insertion
background guidelines released reducing risk viral bloodborne pathogen transmission organ transplantation eleven criteria described result donor designated increased infectious risk human immunodeficiency virus hiv hepatitis virus hcv transmission risk increased risk donor ird despite negative nucleic acid testing nat likely varies based behavior type timing methods developed monte carlo risk model quantify probability hiv among irds model included nat performance viral load dynamics per act risk acquiring hiv behavior model also quantifies probability hcv among irds non medical intravenous drug use ivdu results highest risk among donors history unprotected receptive anal male male intercourse partner unknown hiv status msm followed sex hiv infected partner ivdu sex commercial sex worker conclusion nat screening estimated risk undetected hiv remains small even day following risk behavior estimated risk hcv transmission ivdu likewise small decreases quicker time owing faster viral growth dynamics hcv compared hiv findings may allow improved organ allocation utilization recipient informed consent
renewable energy plays important role provide electrical energy conventional sources wind power one renewable energy sources used minimize environmental impact conventional plant one fastest growing sources energy world however wind power connected electric grid may cause problems important terms power quality effects power quality measurements active power reactive power variation voltage flicker harmonics electrical behavior switching operations paper study demonstrates power quality problem due installation wind turbine grid paper propose study importance use statcom installed wind farm statcom connected point common coupling mitigate power quality issues simulation studies carried matlab simulink environment examine performance wind farm without statcom improving power quality wind farms connected electrical network
aim investigate prevalence risk temporomandibular disorders tmds patients irritable bowel syndrome ibs including subtype constipation diarrhoea mixed compared general population methods january december enrolled consecutively adult patients diagnosed ibs outpatient clinic university salerno healthy controls without ibs enrollment analyzed patients presence tmds according research diagnostic criteria tmd results enrolled ibs patients ibs ibs ibs study found higher risk tmd compared risk tmd independent ibs subtype multiple regression analysis showed facial pain positively related abdominal pain higher level depression conclusion ibs patients three times greater risk tmd compared risk tmd similar different ibs subtypes ibs patients also fulfilled criteria tmd seem share along chronic facial abdominal pain significant occurrence psychiatric disorders female preponderance
given next generation networks expected populated large number devices need quick deployment evaluation alternative mechanisms cope possible generated traffic large scale distributed data networks sense raspberry popular network node choice due reduced size processing capabilities low cost support widely used operating systems information transport network coding new paradigm fast reliable data processing networking storage systems overcomes various limitations state art routing techniques therefore work provide depth performance evaluation random linear network coding rlnc based schemes raspberry models showing processing speed encoding decoding operations corresponding energy consumption results show several scenarios processing speeds mbps raspberry model mbps raspberry model attainable moreover show processing energy per bit network coding even order magnitude less scenarios
active cancellation stealth smart signal blanking method become important developing direction modern stealth technology order explore active cancellation stealth technology considering detection cancellation receiving transmitting antenna pattern different put forward active cancellation system simulation structure diagram based matlab simulink phased array radar system modelling object established active cancellation stealth system mathematical model based digital radio frequency memory orem radar signal processing system coherent video simulation model based linear frequency modulation radar coherent pulse signal simulation verified rationality validity design active cancellation stealth engineering technology laid foundation elsevier gmbh rights reserved
criminal drug prostitution charges employment levels weekly hours recent substance use past months primary sources income examined among sample women offenders opioid use disorders without methadone histories general linear model tested examine differences relation methadone use history results one way mancova found methadone histories reported significantly higher levels drug prostitution charges without methadone history significant differences terms weekly hours employment recent substance use observed groups women offenders methadone histories reported various sources income beyond employment proportionally women reported prostitution primary source income findings suggest methadone maintenance treatments sufficient meeting needs women offenders
ambient intelligence ami deals new world ubiquitous computing devices physical environments interact intelligently unobtrusively people ami environments diverse homes offices meeting rooms schools hospitals control centers vehicles tourist attractions stores sports facilities music devices paper present design implementation testbed ami using raspberry mounted raspbian analyze performance mean shift clustering algorithm considering sensing data evaluation considered respiratory rate heart rate metrics simulation results show mean shift clustering algorithm good performance
exposure paraquat maneb shown increase risk parkinson disease dopaminergic neurodegeneration substantia nigra pars compacta snpc observed treated experimental animals loss noradrenergic locus coeruleus neurons brainstem common feature shared multiple neurodegenerative diseases including however whether able damage neurons remains undefined study mice treated combined displayed progressive neurodegeneration time course studies revealed activation microglia preceded neurodegeneration mechanistically activation nadph oxidase contributed microglial activation subsequent neurodegeneration found exposure induced activation nadph oxidase shown increased superoxide production membrane translocation phox cytosolic subunit nadph oxidase inhibition nadph oxidase apocynin widely used nadph oxidase inhibitor suppressed microglial activation gene expressions proinflammatory factors furthermore reduced activation nuclear factor kappa kappa pathway observed apocynin treated mice importantly inhibition nadph oxidase apocynin afforded neuroprotection induced neurotoxicity thus findings revealed critical role nadph oxidase mediated microglial activation driving neurodegeneration induced pqand providing new insights pathogenesis environmental toxins induced elsevier rights reserved
integrating direct write devices three dimensional printed parts key continuing innovation engineering applications smart material systems structural health monitoring however integration challenging printing techniques leave rough porous surfaces untreated thermal sintering process required conductive inks could degrade polymeric materials printed parts extensive pause needed process layer layer fabrication may cause weaker interlayer bonding create structural weak points challenges rather common insertion conductive patterns inside printed structures avoidance tactic developed simple print stick peel method transfer device polytetrafluoroethylene perfluoroalkoxy alkanes film onto layer printed object transfer achieved using self adhesion printing materials applying additional adhesive demonstrated method transferring aerosol jet printed strain sensors parts fabricated polyjet printing report provides investigation discussion sensitivity reliability influence embedding sensor mechanical properties
background software product line spl scoping important phase planning product line adoption spl scope specifies extent domain supported product line portfolio products product line list assets developed reuse across family products issue spl scope planning usually based estimates state market engineering capabilities development team one challenge estimates inaccuracies due uncertainty environment accuracy measurement may result issues ranging suboptimal plans infeasible plans objective address propose include uncertainty part spl scoping model plans developed consideration uncertainty would robust possible fluctuations estimates approach paper method incorporate uncertainty scoping optimization application generate robust solutions proposed capture uncertainty part formulation model scoping optimization multi objective problem profit stability fitness functions profit stability feasibility stability considered represent stability concerns results results show compared scope optimization approaches performance stability feasibility stability improved maintaining near optimal performance profit objective also generated results consist solutions trade offs profit stability providing decision maker enhanced decision support conclusion multi objective optimization stability consideration spl scoping provides project managers robust flexible way address uncertainty process spl scoping elsevier ltd rights reserved
objective investigate efficacy safety outcomes combination therapy used optimize etanercept treatment patients psoriasis treated real life clinical practice methods data patients presenting psoriasis treated initially etanercept monotherapy analysed retrospectively patients subsequently treated combination therapy analysed psoriasis area severity index pasi score recorded patients receiving comedication subjective pain score recorded psoriatic arthritis receiving comedication weeks treatment thereafter month intervals results database patients treated etanercept patients male female mean age years underwent combination therapy due lack efficacy patients received mostly short term range weeks comedication corticosteroids cyclosporine methotrexate nonsteroidal anti inflammatory drugs acitretin sulphasalazine significant reductions mean pasi score baseline timepoints also significant reductions mean pain vas score baseline timepoints patients psoriatic arthritis drug survival rate mean duration weeks etanercept treatment safety profile combination therapy satisfactory conclusions short term comedication combination etanercept may optimize treatment options improve long term drug survival patients psoriasis
practice shows best built maintain knowledge based secured personal work experience source expertise carried laboratory theoretical practical experiments study key development system hamper inappropriate use lack tools enable students deal challenge problem phenomenon monitoring experiments entering selecting initial data new technology especially electronic progress important allows development continuing education distance education democratization adapting people different capabilities needs discussed problem creating different type laboratory key novelty virtual laboratory based software tools real remote controlled electronics lab produced simplified conceptual model remote laboratory experiments demonstration article describes real remote laboratory designed applied vilniaus kolegija university applied sciences experimental practical method distance learning
paper presents approach static dynamic visualizations synchronized along source code web based programming environment javelinacode using javelinacode student programmers write java programs directly frontend web browser without software plug installation provided view static state java program uml class diagrams dynamic run time state program stepping forwards backwards program execution case study revealed approach useful particular trace detect object flow anomaly caused method overriding polymorphism preliminary comparison test result also shown web based platform independent environment student programmers freed concern continuous version changes evolutions java language plug ins operating systems
many studies suggest sex differences memory hippocampal size hormone therapy may positively affect measures women however parameters use likely confer benefits debated evaluated impact sex postmenopausal use verbal learning memory hippocampal size cognitively intact women men using analysis covariance controlled age education women better total word learning delayed verbal memory performance men analyses showed non users performed similarly men users performed better men delayed memory regardless whether use current past women larger hippocampal volumes men regardless whether users using univariate linear models assessed group differences predictive value hippocampal volumes verbal learning memory hippocampal size significantly predicted memory performance men non users users lack relationship hippocampal size verbal learning memory performance users suggests use may impact memory extra hippocampal neural systems
parkinson disease movement disorder caused dopamine depletion basal ganglia abnormally synchronized neuronal oscillations basal ganglia implicated motor symptoms parkinson disease however abnormal oscillations generated maintained dopamine depleted state unknown based neural recordings primate model parkinson disease experimental computational evidence hypothesized recurrent circuit subthalamic nucleus stn external segment globus pallidus gpe generates maintains parkinsonian oscillations cortical excitatory input stn amplifies investigate hypothesis computer simulations developed spiking neuron model stn gpe circuit incorporating electrophysiological properties neurons synapses systematic parameter search computer simulation identified regions space intrinsic excitability gpe neurons synaptic strength gpe stn reproduce normal parkinsonian states parkinsonian state reduced firing gpe neurons increased gpe stn inhibition trigger burst activities stn neurons strong post inhibitory rebound excitation usually subject short term depression stn neuronal bursts shaped synchronous oscillations via recurrent interactions stn gpe neurons furthermore show cortical excitatory input stn amplify suppress pathological stn oscillations depending phase strength predicting conditions cortical inputs stn suppressing oscillations
subspace identification techniques popular parametric time domain method extracting modal parameters structure ambient condition techniques simultaneously process large quantity data potentially extract information measurement developed subspace identification techniques however assume white noise input hence used structures earthquake excitation study input output recursive combined subspace identification technique proposed tracking modal parameters time varying structure nonstationary earthquake excitation technique incorporates orthogonal projection instrumental variable approach eliminate effect earthquake input measurement noise respectively iteration subspace tracker applied extract step step structural modal parameters proposed technique validated numerically four degree freedom structure experimentally three degree freedom building model numerical experimental results show proposed technique track structural modal parameters nonstationary earthquake excitation quite well
solving boundary value problems shapes boundary modelled curves widely used computer graphics parametric integral equations system pies curves directly included mathematical formalism simplify way definition modification shape boundary pies spline bezier hermite curves used recent developments computer graphics paid attention therefore implemented pies possibility defining shape boundary using nurbs curves curves allow modeling different shapes precisely paper compare pies solutions applied nurbs solutions existing literature
magnesium sulphate potential treatment acute severe asthma however mechanisms dose response relationships poorly understood first objective study examine whether inhaled magnesium sulphate exerts bronchodilator activity measured bronchoprotection histamine induced bronchoconstriction conscious guinea pigs alone combined salbutamol secondly examined whether inhaled magnesium sulphate inhibits airways inflammation function models neutrophilic eosinophilic lung inflammation induced respectively inhaled lipopolysaccharide inhaled antigen ovalbumin ova airway function measured conscious guinea pigs specific airway conductance whole body plethysmography anti inflammatory activity measured lung inflammatory cell influx induced ova inhalation ova sensitised animals lipopolysaccharide lps exposure non sensitised animals airway function measured ova exposure airway hyperresponsiveness inhaled histamine inflammatory cells bronchoalveolar lavage fluid recorded ova lps challenge histamine induced bronchoconstriction inhibited inhaled magnesium sulphate salbutamol alone combination produced synergistic bronchoprotection lps induced neutrophil influx inhibited days pretreatment magnesium sulphate early late asthmatic responses ova sensitised challenged animals attenuated magnesium sulphate lung inflammatory cells increased ova macrophages significantly reduced magnesium sulphate nebulised magnesium sulphate protects histamine induced bronchoconstriction conscious guinea pigs exerts anti inflammatory activity pulmonary inflammation induced allergen ova lps properties magnesium sulphate explain beneficial actions acute asthma
describe case studies clinically significant changes sedentary behavior older adults captured novel computer vision algorithm depth data unobtrusive microsoft kinect sensor continuously recorded older adults activity primary living spaces tigerplace apartments using depth data period ten months develop context aware algorithm detect person specific postural changes sit stand stand sit events define sedentary behavior robustness algorithm validated minutes data residents manual analysis raw depth data ground truth strong correlation mean error minutes day findings highlighted two case studies sedentary activity relationship clinical assessments functional decline findings show strong potential future research towards generalizable platform automatically study sedentary behavior patterns home activity monitoring system
response call sustainability education construction courses higher education institutions started incorporate sustainability components construction courses extent research aims investigate sustainability embedded construction management courses using queensland university technology case study content analysis course structure unit aims learning objectives lecture materials conducted examine sustainability elements incorporated curriculum results show course incorporates sustainability components existing course structure mainly horizontal integration embedding sustainability general units rather add subject additionally sustainability topics embedded course cover comparatively broad balanced range sustainability categories background knowledge policies regulations environmental issues social issues economic issues well technology innovation although social sustainability aspects need strengthened research addresses need urgency development effective sustainability education framework construction courses expected findings study facilitate improvement sustainability education construction courses generally
past decades distance metric learning attracted lot interest machine learning related fields work propose optimization framework distance metric learning via linear transformations maximizing jeffrey divergence two multivariate gaussian distributions derived local pairwise constraints method distance metric trained positive negative difference spaces built neighborhood training instance local discriminative information preserved show solve problem closed form solution rather using tedious optimization procedures solution easy implement tractable large scale problems experimental results presented linear kernelized version proposed method nearest neighbors classification obtain classification accuracies superior state art distance metric learning methods several cases competitive others
novel label free immunosensor based hyperbranched polyester nanoparticles nitrite groups hbpe synthesized simple one step chemical reaction first developed specific detection fetoprotein afp tumor marker liver cancer obtained hbpe nanoparticles nps characterized proton nuclear magnetic resonance spectroscopy nmr ray photoelectron spectroscopy xps ray diffraction xrd fabricated process immunosensor investigated attenuated total reflection fourier transform infrared spectra atr ftir static water contact angles scanning electron microscope sem cyclic voltammetty electrochemical impedance spectroscopy eis electrochemical performances afp immunosensor studied results indicated prepared hbpe modified immunosensor showed excellent electrochemical properties satisfactory accuracy detection afp real clinical samples attributed properties hbpe nps nanosized structure increase specific surface area unique chemical reactivity loading capacity protein molecules construction biosensors using structure properties hyperbranched molecules offer ideal electrode substrates provided possibilities design biosensor
reducing number satellite images various periods good quality caused changes climate conditions also typhoons rainy seasons various atmospheric changes continuous image production identification changes biophysical characteristics become increasingly difficult remedy production simulated image consider user preferred periods satellite geometric information one alternatives study simulated image generation method uses back project collinearity conditions atmospheric simulation proposed create input data generation simulated image produced spot hrvir satellite image geometric atmospheric corrections processed analysis results similarity simulated image target image show average addition experimental results image application field showed case natural color composite pixels correlation coefficient greater occupied total image results ndvi index frequently used forestry field showed two images results similarity analysis showed land cover classification performed using maximum likelihood classification average similarity per land cover achieved compared target image results verify similarity simulated image target image applicability simulated image
paper investigates discourses defense morality arose around book mademoiselle cinema benjamin costallat first released work brazil biggest publishing success first decades twentieth century came collected police charges offensive moral good customs reason behavior central character far expected girls age seizure book aroused intense debate considered moral immoral even gender roles society article investigate intersection lines aiming demonstrate differences moral consensus arose
cancer incidence patients recurrent unprovoked venous thromboembolism vte much higher first event incidence myeloproliferative neoplasms mpn situation still unknown tested jakvf calreticulin mutants dna samples patients treated vtr among patients carrying jakvf mutation none calreticulin calr mutations among patients vte recurrence vitamin antagonists patients positive jakvf despite identification jakvf mutation three patients diagnosed mpn despite median follow years showed screening jakvf calr mutations helpful indication especially recurrence happened vka therapy
aim study aims identify predictors poor sleep quality associations depression hope sleep sample women breast cancer prior surgery background care treatment breast cancer among important scientific challenges public health sleep disturbances depression important complaint cancer patients however often neglected patients diagnosed breast cancer also experience prejudice fear death suffering mutilation fear lymphedema well feelings social devaluation leading hopelessness several studies point hope effective strategy help patients cope difficulties achieve goals especially patients cancer methods report baseline data extracted longitudinal study data collection tools pittsburgh sleep quality index beck depression inventory herth hope index data analyzed spearman rank correlation test multiple logistic regression analysis results majority women tumors initial stages reported poor sleep quality moderate severe severe depression significant correlations found hope depression spearman sleep quality depression spearman significant associations found poor sleep quality pain symptoms menopause depression depression symptoms menopause independent predictors poor sleep quality conclusion evaluation sleep quality depression hope implemented clinical practice increased hope lessens depression may positively affect sleep quality improves quality life women breast cancer elsevier inc rights reserved
field ambient assisted living best results achieved systems less intrusive intelligent easily integrate formal informal caregivers easily adapt changes situation elderly disabled person paper presents graph based representation context information simple intuitive method situation recognition input results easy visualize understand use experiments performed several aal specific scenarios
work introduced tih mgh composite ball milling improving dehydrogenation performance reactive system according measurements non isothermal dehydrogenation onset temperature hydrogen release mgh tih reduced degrees mgh investigations kissinger method showed activation energy hydrogen desorption mgh tih mol much lower mgh mol leading enhanced dehydrogenation kinetics due tih additive ray diffraction xrd analysis suggests tih catalyzed reaction mgh system dehydrogenation degrees temperatures degrees degrees however tih thoroughly react produced mgal liberate hydrogen overall reaction system may represented mgh tih mgal alti theoretical dehydrogenation capacity agrees well achieved temperature programmed dehydrogenation tpd measurements demonstrating occurrence reaction dehydrogenation enthalpy mgh tih mol proceeding lower hydrogen desorption plateau significantly lowered mgh mol according measurements pressure composition isotherms pci van hoff plots means tih involved end reaction proceeding mgh system believe tih improves dehydrogenation kinetics mgh initially tailors thermodynamics finally elsevier rights reserved
introduction invasive fungal infection among leading causes morbidity mortality economic burden patients acute leukemia induction chemotherapy past decades incidence invasive fungal infection increased dramatically management complicated increasing frequency infection non aspergillus molds mucorales neutropenic patients high risk developing invasive mucormycosis fulminant course high mortality rate case outline presenting case year old male acute monoblastic leukemia patient treated five days hydroxycarbamide day followed cytarabine next days developed febrile neutropenia headache edema right orbital region face computed tomography sinuses revealed shadow sinuses thickening mucosa right paranasal sinuses lavage aspirate sinuses revealed rhizopus oryzae mucormycosis successfully treated amphotericin day followed ketoconazole day two months later patient died primary disease conclusion patients acute leukemia developed aplasia febrile neutropenia pain paranasal sinuses fungal infection taken consideration new non invasive methods taking samples sinuses standardized order establish early accurate diagnosis mucormycosis source paranasal sinuses start early treatment proper antifungal drug clear communication physician mycologist critical ensure proper timely sampling lavage aspirate sinuses correct specimen processing mucormycosis suspected clinically
gaseous helium considered cryogen variety high power density applications capable reaching operational temperature levels low paper presents time efficient method designing modeling high temperature superconducting cable analysis extension previously presented mathematical model volume element method used characterize fluid flow heat transfer conduction convection radiation flexible cable cryostat system ordinary differential equations formulated using fundamental principles thermodynamics computational domain consists volume elements distributed three dimensions account spatial dependence model pressure drop gaseous helium calculated based darcy weisbach correlation additionally temperature distribution solved numerically using adaptive time stepping obtained solutions converge within timescale order seconds minutes steady state results along transient analysis discussed
understanding hydraulic behaviour subsurface flow bioremediation systems pre requisite characterising biogeochemical functioning yet often overlooked using multiple tracers parallel considerable hydraulic insight gained quantitative multi tracer test conducted passive coal mine water bioremediation system bowden close colliery county durham assess hydraulic behaviour four tracers used bromide uranine fluorescein lithium nacl system comprises two parallel treatment streams one receiving min moderately acidic adit drainage one min strongly acidic spoil leachate treatment streams separate raps unit reducing alkalinity producing system effluents eventually mixed single aerobic wetland raps units downward flow porous media mixed substrates limestone gravels compost raps surface area raps aerobic wetland basin mineral soil planted typha latifolia shallow water level two raps units residence times effective velocities deduced terms tracer performance contrast earlier findings bromide fluorescein tracers applied successfully nacl lithium found least useful particularly dilution events caused intense rainfall elsevier rights reserved
recent studies indicate immune system adaptation pregnancy could play significant role pathophysiology perinatal depression aim study investigate inflammation markers late pregnancy plasma sample predict presence depressive symptoms eight weeks postpartum blood samples pregnant women median iqr days delivery days respectively comprising individuals postpartum depressive symptoms assessed edinburgh postnatal depression scale epds mini international neuropsychiatric interview controls analyzed inflammation protein panel using multiplex proximity extension assay technology comprising inflammation associated markers summary inflammation variable also calculated logistic regression lasso elastic net analyses implemented forty markers lower late pregnancy among women depressive symptoms postpartum difference remained statistically significant stam otherwise amsh axin ada sta bonferroni correction summary inflammation variable ranked second best variable following personal history depression predicting depressive symptoms postpartum protein level findings stam sta validated relation methylation status loci respective genes different population using openly available data explorative approach revealed differences late pregnancy levels inflammation markers women presenting depressive symptoms postpartum controls previously described literature despite fact results support use single inflammation marker late pregnancy assessing risk postpartum depression use stam novel notion summary inflammation variable developed work might used combination biological markers future authors published elsevier ltd
image denoising one fundamental essential tasks within image processing medical imaging finding effective algorithm remove random noise images important paper proposes effective noise reduction method brain magnetic resonance images approach based collateral filter powerful method bilateral filter many cases however computation collateral filter algorithm quite time consuming solve problem improved collateral filter algorithm parallel computing using gpu adopted cuda application programming interface gpu nvidia accelerate computation experimental evaluation intel xeon cpu ghz nvidia tesla gpu indicated proposed implementation runs dramatically faster traditional collateral filter believe proposed framework established general blueprint achieving fast robust filtering wide variety medical image denoising applications
background muscle injuries among common sports related lesions athletes however optimal treatment remains obscure extracorporeal shock wave therapy eswt may promising approach context gained increasing importance tissue regeneration various medical fields hypothesis eswt stimulates accelerates regenerative processes acute muscle injuries study design controlled laboratory study methods adult sprague dawley rats divided experimental groups eswt groups eswt groups well uninjured control group group acute cardiotoxin induced injury set quadriceps femoris muscle rats experimental groups single eswt session administered injured muscles eswt groups day injury whereas eswt groups received treatment days injury eswt eswt groups euthanized regenerating lesions excised analyzed histomorphometry immunohistochemistry assess fiber size myonuclear content recruitment satellite cells results size myonuclear content regenerating fibers eswt muscle significantly increased compared eswt muscle fibers days injury similarly time points eswt muscles exhibited significantly higher contents pax positive satellite cells mitotically active cells cells expressing myogenic regulatory factors myod myogenin indicating enhanced proliferation differentiation rates satellite cells eswt mitotic activity days injury doubled eswt compared eswt muscles conclusion eswt stimulates regeneration skeletal muscle tissue accelerates repair processes clinical relevance provide evidence accelerated regeneration damaged skeletal muscle eswt although studies necessary findings support view eswt effective method improve muscle healing special relevance sports injuries
construction safety management improvement could aligned condition workplace aim research identify significant safety practices intervention levels improving behavioral safety performance workers construction industry literature review used identify determine relevance list safety intervention practices take place various levels total safety practices identified questionnaires circulated measure level significant safety intervention practices towards positive behavioral safety performance workers targeted respondents safety personnel middle level personnel construction companies manage differ construction projects oil gas infrastructure building projects data collected least respondents analyzed using structural equation modelling sem determine significant safety practices intervention level first result references develop dynamic model integrated multilevel safety intervention practices construction industry findings expected useful guidance safety construction management order improve behavioral safety performance multinational worker authors published elsevier ltd
day day network internet applications becoming popular sensitive information requires security safety measures security challenging aspect internet network applications encryption algorithm provides necessary protection data intruders attacks converting information normal form unreadable form majority current web authentication built username password password replacement offers security much difficult use expensive deploy security data done technique called cryptography everybody say cryptography developing technology important network security cryptography past used keeping military information secure protect national security however use limited present range cryptography applications expanded lot modern area development communication means cryptography essentially required ensure data protected penetrations prevent practice spying cryptography developing technology important network security study cryptography still developing stages considerable research effort still required secured communication paper talks state art broad range cryptographic algorithms used networking applications
magnetic damper introduced high speed rotating machinery restrain vibration rotor supported active magnetic bearings experimental setup made one rotor two radial active magnetic bearings one axial active magnetic bearing one magnetic damper control system built investigate effects magnetic damper locations dynamic characteristics system theoretical analysis experimental modal analysis actual operation system results show vibration active magnetic bearing system operating modal frequency reduced effectively magnetic damper located far nodes corresponding mode shape
immunodysregulation polyendocrinopathy enteropathy linked ipex syndrome rare linked recessive disease affects regulatory cells tregs resulting diarrhea enteropathy eczema insulin dependent diabetes mellitus ipex syndrome caused pathogenic alterations foxp located foxp encodes transcription factor interacts several partners including nfat kappa necessary proper cellular differentiation tregs although variable vast majority ipex syndrome patients onset disease infancy severe enteropathy five families prenatal presentation ipex syndrome reported present two additional prenatal onset cases novel inherited frameshift pathogenic variants foxp generate premature stop codons ultrasound findings first patient identified echogenic bowel echogenic debris scalp edema hydrops second patient ultrasound findings included polyhydramnios echogenic debris prominent fluid filled loops bowel echogenic bowel cases broaden phenotypic spectrum ipex syndrome describing previously unappreciated prenatal ultrasound findings associated disease
based fuzzy decision theory multi objective fuzzy optimization done three dynamic model scheme self anchored cable stayed suspension bridge combining fuzzy decision method engineering practice using two comparison theory solves problem quantifying qualitative indexes comparison results show reasonable place viscous dampers main tower girder longitudinal displacement mid span girder time method provide reference structure selection practical conceptual design phase
significant role kinesiology classes involving students suffering hearing impairments played communication students aim improve communication skills encouraging use best mode communication creating opportunities socialization integration process games physical therapy lesson others role teacher transmit knowledge pupils specific language due particularities pupils verbal communication class may accompanied nonverbal communication visual symbols expressive didactic communication involves elements teacher attitude way dressing motor behavior facial expression use certain gestures symbols video well use permanent eye contact students throughout classes research aims highlighting types communication verbal nonverbal visual symbols may significance contribute effective communication kinesiology classes authors published elsevier ltd
substrate stiffness known impact characteristics including cell differentiation proliferation migration apoptosis hydrogels polymeric materials distinguished high water content diverse physical properties gradient stiffness hydrogels designed need develop biologically friendly materials extracellular matrix ecm alternatives replace separated narrow ranged hydrogel substrates important new discoveries cell behaviors realized model gradient stiffness hydrogel systems two dimensional three dimensional scale basic clinical applications gradient stiffness hydrogels tissue engineering regenerative medicine continue drive development stiffness structure varied hydrogels given importance gradient stiffness hydrogels basic research biomedical applications clear need systems gradient stiffness hydrogel design strategies applications review highlight past work field gradient stiffness hydrogels fabrication methods mechanical property test applications well areas future study wiley periodicals inc
natural phenomena simulation attracted spurt research attention interest computer graphics virtual reality technology domains water one common phenomena real world acquisition modeling different water movements become one important research topics recent years paper design acquisition system capturing dynamic water surface also present image based method water surface reconstruction goal water surface reconstruction compute coordinates normals dynamic water surface
study examines depiction central female characters cfcs promotional film posters trailers top grossing hollywood bollywood films focusing gender stereotypes sexualization aggression whereas bollywood characters tended sexualized fit less prominent hollywood characters appeared frequently increasingly unrealistic typically occupying role attractive love interests cfcs tended display aggressive behavior time attractive aggressive cfcs may reinforce challenge gender role expectations promoting superwoman ideal findings discussed terms objectification globalization cultivation social cognitive theory
present paper summarizes results experimental trails hcci engine fuelling producer gas substitute engines single cylinder units similar displacement volume original version hcci engine used three cylinder engine two cylinders disabled engine modified hcci operation engine used component commercially available generator engine original intake manifold ignition system rebuild purpose study engines fuelled producer gas substitute simulated real producer gas composition engine charged stoichiometric air fuel mixture hcci engine lean air fuel mixture equivalence ratio main control variable engine operation spark timing initial air preheat temperature equivalent control variable hcci engine trials paper reports engines indicated performance combustion phasing parameters derived based cylinder cycle resolved pressure measurements elsevier ltd rights reserved
shot peening surface process widely used improve fatigue strength materials compressive residual stresses induced surface layers considering mechanical components high responsible applications wear corrosion control currently accomplished use coated materials case chrome plating hard anodizing lower fatigue strength comparison uncoated parts associated high residual tensile stresses microcracks density constant variable amplitude loading microcracks propagate cross interface coating substrate without impediment aim present study analyze influence coating applied hvof process axial fatigue strength aisi steel shot peening effect fatigue performance coated aisi steel also evaluated fractured fatigue specimens investigated using scanning electron microscope order obtain information crack initiation points published elsevier ltd
ethnopharmacological relevance root saussurea costus aucklandia lappa decne aucklandiae radix thuja orientalis tol traditionally used anti inflammatory agents korea however studied efficacy atopic dermatitis treatment chronic inflammatory skin disease investigated efficacy topical applications butyleneglycol extracts tol alleviate symptoms materials methods hacat cells dorsal skin nga mice local exposure house mite extracts dinitrochlorobenzene dncb respectively lesions developed topically applied butylen glycol vehicle control tol tol skin lesions weeks normal control exposed dncb skin thickness mast cell infiltration serum immunoglobulin ige igg gene expressions interleukin ifn gamma dorsal skin hacat cells measured results chlorogenic acid catechin apigenin respectively tol used indicator compounds strength extracts tol decreased expression protease activated receptor icam release tnf alpha hacat cells activated house mite extracts comparison either tol alone nga mice challenged dncb tol synergistically attenuated clinical symptoms erythema hemorrhage edema excoriation dryness dorsal skin better either tol alone histological analysis dorsal skin also showed tol treatment significantly additively decreased inflammatory cellular infiltrate including mast cells eosinophils comparison either tol tol also decreased serum ige igg levels expression ifn gamma mrna dorsal skin dncb treated nga mice conclusion tol relieved symptoms reducing pro inflammatory activity activated immune responses data suggest tol may effective alternative intervention management
application expansion method search exact solutions nonlinear partial differential equations analysed method used burgers fisher huxley equations combined forms equations expansion method used construct periodic wave solitary wave solutions nonlinear evolution equations method developed searching exact travelling wave solutions nonlinear partial differential equations shown expansion method help symbolic computation provides straightforward powerful mathematical tool solving nonlinear partial differential equations
paper optimal lightweight foamed mortar mix suitable proposed facilitating tunnel drainage carried using composite lining method physical performance evaluation pore structure analysis provided order assess performance different lightweight foamed mortar mix proportions various void fractions foam solution concentrations furthermore basis plane permeability test simulated permeation fines soil leaking underground water formation distribution open cell foams measuring outflow characteristics outflow volume mix nonwoven geotextile lightweight foamed mortar existing tunnel drainage materials examined consequently mix employing foaming agent dilution rate showed better drain performance mixes appropriately formed distributed open cell foams key component tunnel drainage words mix dilution rate thought achieved stable closed cell foams decline surface tension foams well optimal formation distribution open cell foams possess excellent permeability cohesiveness foams moreover thickness drainage space approximately times nonwoven geotextile closed cell open cell foams connected like spider web could expected reduce blocking drainage caused fines soil elsevier ltd rights reserved
every cognitive process including conceptualization perceived facts human disease states entails emotional evaluative aspect regarding cross cultural research shown common human value contents therefore human phylogenetic context plausible argue along development language hetero perception self perception specific human states termed descriptively communicate adaptive significance case human states whose properties conceptualized corresponding evaluative emotional component disease since names symbols language designate type object either perceptual conceptual reviewing etymology terms related disease could contribution elucidation consequence equivalent terms spanish word enfermedad reviewed various indo european non indo european languages analyzed denominations conclude different words described perception human conditions weak evil suffering states etc therefore denotative concordance diseased human states revised cultures
purpose review review focuses pathophysiological clinical aspects diabetes mellitus occurring patients cushing disease recent findings insulin resistance impairment insulin secretion involved pathogenesis glucocorticoid induced diabetes correction glucocorticoid excess always resolve abnormalities glucose homeostasis connection hyperglycaemia specifically required fact insulin resistance may persist even correction glucocorticoid excess diabetes needs treated long term hand emerging drugs used treatment novel somatostatin analog pasireotide may direct effects glucose homeostasis regardless control cortisol excess summary diabetes mellitus frequent early complication important diagnostic prognostic therapeutic implications specifically diagnosis patients diabetes may difficult due potential misinterpretation markers cortisol hyper secretion moreover diabetes mellitus often difficult controlled requiring careful dedicated therapeutic approach finally coexistence diabetes may influence therapeutic decision making since drugs used setting may variably influence glucose homeostasis regardless control hypercortisolism
hotfiel swoboda krinner grim engelhardt uder heiss acute effects lateral thigh foam rolling arterial tissue perfusion determined spectral doppler power doppler ultrasound strength cond res foam rolling developed popular intervention training rehabilitation however evidence effects cellular physiological level lacking aim study assess effect foam rolling arterial blood flow lateral thigh twenty one healthy participants age years height body weight recruited medical sports faculty arterial tissue perfusion determined spectral doppler power doppler ultrasound represented peak flow vmax time average velocity maximum tamx time average velocity mean tamn resistive index semiquantitative grading assessed blindfolded investigators measurement values assessed resting conditions twice foam rolling exercises lateral thigh minutes intervention trochanteric region mid portion distal tibial insertion lateral thigh representative data analysis arterial blood flow lateral thigh increased significantly foam rolling exercises compared baseline detected relative increase vmax minutes minutes tamx tamn semiquantitative power doppler scores portions revealed increased average grading intervention minutes compared baseline results may contribute understanding local physiological reactions self myofascial release
prior work true false memory influenced emotion valence arousal often conflated thus difficult say specific effects caused valence caused arousal present research used picture memory paradigm allowed emotional valence manipulated arousal held constant negatively valenced pictures elevated true false memory relative positive neutral pictures conjoint recognition modeling revealed negative valence reduced erroneous suppression true memories increased familiarity semantic content true false memories overall negative valence impaired verbatim side episodic memory enhanced gist side effects persisted even week long delay
geosynthetics proposed use method increasing bearing capacity soil medium footing reducing settlement study load settlement behaviour strip footings investigated experimentally numerically ultimate load centrally eccentrically loaded model strip footings resting reinforced unreinforced sand determined plane strain conditions sand placed tank relative density obtain general shear failure numerical simulation experimental set carried using plaxis software woven geotextile used soil reinforcement mohr coulomb material model utilised model sand load settlement curves obtained numerically using reinforcement caused increase ultimate load numerical simulations laboratory tests effect changes ultimate bearing capacity due load eccentricity investigated using numerical analytical methods
selective laser melting slm process additive manufacturing technology rapid growth biomedical aerospace markets ability manufacture complex designs directly computer aided design cad using materials titanium aluminum alloys although technology allows designers fabricate geometries achievable conventional manufacturing restrictions paper presents technological problems restrictions resulting production structures aluminum alloy slm particular analyzed input file process stl file dimensional limits geometries sharp edges simple parallelepiped square base since understanding limitations help designer creation new components creation function independent design rules easily transferrable individual part designs could allow wide industrial usage better knowledge technologies results presented paper showed choice parameters conversion cad model stl file could restriction software preprocessing part also affects surface roughness moreover slm machine laser beam used possible produce geometries sharp edges size base aluminum alloy
lot research done improve fatigue strength materials creating compressive residual stress field surface layers shot peening present work found relaxed residual stress field varies shot peening intensity affects weight spring steel leaf springs stress approach model weight reduction leaf springs used automotive vehicles experimentally developed simulating industrial environment paper discusses time saving reliable method predicting thickness weight leaf springs various shot peening intensities industrial applications model based experimental results developed predicts weight reduction leaf springs given stress varying shot peening conditions authors published elsevier ltd selection peer review responsibility american applied science research institute
despite multiple risk factors mortality among people inject drugs pwid research warranted examines sub populations within pwid mortality data pwid participating longitudinal hiv prevention research denver obtained colorado department public health environment risk factors cause acute toxicity related mortality analyzed using cox proportional hazards regression two thousand seven individuals interviewed baseline eighty six individuals died time frame study due acute toxicity disabled gay lesbian identified white race ethnicity use shared cooker important adjusted risk factors suggest drug hiv interventions utilize techniques address needs marginalized populations addition hiv drug risk behaviors
dolphins exhibit prosocial behavior across several different contexts however experimental studies investigated psychological mechanisms underlying behavior study investigated mechanisms underlying prosociality bottlenose dolphins tursiops truncatus experiments water shower devices developed environmental enrichment items used two paradigms used measure prosociality first prosocial choice task involving subject typically offered one choice two options first option provided reward take shower subject partner prosocial choice second option provided reward subject selfish choice second paradigm giving assistance task involving subject provided choice providing instrumental help partner prosocial choice nothing observed subjects chose prosocial choices paradigms experiments prosocial choices spontaneously taken without requests partners results indicated dolphins show preference regarding behavior elsevier rights reserved
demonstrated increase glutamate neurocytotoxicity cultured cerebellar cells rat pups subjected lead poisoning prenatal development early lactation period toxic effect glutamate weaker lead applied combination antioxidant comenic acid data discussed view practical use comenic acid therapy brain tissues subjected lead poisoning
backgroundalthough music therapy considered effective intervention young people mental health needs efficacy clinical settings unclear therefore examined efficacy clinical practice methodstwo hundred fifty one child years social emotional behavioural developmental difficulties parent dyads six child adolescent mental health service community care facilities northern ireland randomised weekly sessions plus usual care final analyses usual care alone final analyses follow occurred weeks weeks postrandomisation primary outcome improvement communication social skills improvement system rating scales ssis weeks secondary outcomes included social functioning self esteem depression family functioning resultsthere significant difference child ssis week adjusted difference mean guardian ssis however participants aged intervention group child ssis communication significantly improved guardian ssis overall self esteem significantly improved depression scores significantly lower week significant difference family social functioning week conclusionswhile findings provide evidence integration music therapy clinical practice differences relating subgroups secondary outcomes indicate need study isrctn register isrctn
laser cutting advanced processing technology according computer aided design graphics cut variety shapes surfaces many polymer sheets work aims analyze effect laser power scanning speed processing times surface roughness polymethyl methacrylate microchannels laser lcjg cutting process several experiments designed results analyzed orthogonal experimental method finally optimal power scanning speed processing times obtained optimal case arithmetical mean roughness reach small
reliable knowledge solar radiation essential requirement designing planning solar energy systems thus paper presents novel hybrid model predicting hourly global solar radiation using random forests technique firefly algorithm hourly meteorological data used develop proposed model firefly algorithm utilized optimize random forests technique finding best number trees leaves per tree forest according results best number trees leaves per tree trees one leaf per tree forest three statistical error values namely root mean square error mean bias error mean absolute percentage error used evaluate proposed model internal external validation moreover results proposed model compared conventional random forests model conventional artificial neural network optimized artificial neural network model firefly algorithm show superiority proposed hybrid model results show root mean square error mean absolute percentage error mean bias error values proposed model respectively moreover proposed random forests model shows better performance compared aforementioned models terms prediction accuracy prediction speed elsevier ltd rights reserved
background driver mutations jakvf mplwl calr influence disease phenotype myeloproliferative neoplasms mpns might sustain condition chronic inflammation pentraxin ptx high sensitivity reactive protein crp inflammatory biomarkers potentially useful refining prognostic classification mpns methods evaluated essential thrombocythemia polycythemia vera patients diagnosed according criteria full molecular characterization driver mutations results ptx levels significantly increased carriers homozygous jakvf mutation compared genotypes triple negative patients crp levels independent mutational profile risk haematological evolution death cause fold increased individuals high ptx levels thrombosis rate tended lower high crp levels associated risk haematological evolution death also major thrombosis sequential adjustment potential confounders age gender diagnosis treatments presence jakvf homozygous status high crp levels remained significant outcomes jakvf homozygous status well treatments factors independently accounting adverse outcomes among patients high ptx levels conclusions results provide evidence jakvf mutation influences mpn associated inflammation strong correlation allele burden ptx levels plasma levels crp ptx might prognostic value patients validation future prospective studies needed
research explored relationship executive functions working memory reasoning subtests wechsler adult intelligence scale trail making stroop tests fluency planning tasks wisconsin card sorting test emotional intelligence measured mayer salovey caruso emotional intelligence test patients schizophrenia borderline personality disorder compared control group expected clinical groups performed worse control group executive functions emotional intelligence although impairment greater borderline personality disorder group executive functions significantly correlated social functioning results discussed relation brain circuits mediate executive functions emotional intelligence findings obtained models social cognition elsevier ireland ltd rights reserved
shallow coastal areas oceans seas lakes pose significant remote sensing navigational challenges due transient nature bathymetric features characterize areas shoals shoaling seabed data maps often represent areas white ribbon zones sparse data coverage presents particular challenge defining enforcing sustainable use marine resources given lengthy perimeter coastlines need cost efficient methods producing high resolution maps shallow areas research described compares airborne light detection ranging lidar shipboard acoustic surveys around kvarken archipelago northern baltic sea kvarken archipelago includes unique brackish shallow water marine environment number moraines landscape area characterised fields ridged washboard like geer moraines moraines combined ongoing glacio isostatic uplift typical area lead succession elevated structures seafloor land present seabed structures rise land future ongoing modification environment climatic geologic forces contributes complex geomorphic ecological feedback systems operating range spatial temporal scales airborne lidar provide high resolution remote sensing data shallow coastal areas technology especially effective areas shoal waters like found along finnish coast lidar enables continuous detection topographic elevation bathymetric depth data thus generate continuous maps transition zones continental marine areas environmental conditions water clarity ice cover affect lidar depth detection capabilities conditions require complementary accuracy assessment strategies lidar determine detailed information seafloor surface substrate anything subsurface substrate type geological conditions determined application acoustic seismic methods sediment sampling underwater video data lidar surveys provide detailed topographic bathymetric map study area water depths seabed bathymetry model shows series elevated narrow elongate features appear throughout study area parallel ridges represent uppermost geomorphic features seafloor interpretation acoustic bathymetric surveys indicates ridges geer moraines general orientation moraines differs associated older features northern kvarken archipelago eroded remnants older geer moraines overprinted high angle younger landforms geer moraines study area thus represent two phases deglaciation finally eastward ice sheet ice edge retreat combined approach using lidar acoustic bathymetric data provides new insights past glacial dynamics kvarken archipelago gulf bothnia published elsevier
photometric redshifts photo fundamental galaxy surveys address different topics gravitational lensing dark matter distribution galaxy evolution kilo degree survey kids european southern observatory eso public survey vlt survey telescope vst provides unprecedented opportunity exploit large galaxy data set exceptional image quality depth optical wavebands using kids subset galaxies measured spectroscopic redshifts derived photo using three different empirical methods based supervised machine learning bayesian photometric redshift model bpz iii classical spectral energy distribution sed template fitting procedure phare confirm regions photometric parameter space properly sampled spectroscopic templates machine learning methods provide better redshift estimates lower scatter smaller fraction outliers sed fitting techniques however provide useful information galaxy spectral type effectively used constrain systematic errors better characterize potential catastrophic outliers classification used specialize training regression machine learning models demonstrating hybrid approach involving sed fitting machine learning single collaborative framework effectively used improve accuracy photo estimates
reproductive history exogenous hormonal exposures acknowledged risk factors breast cancer general population women increased breast cancer risk genetic predisposition positive family history data regarding risk factors limited conflicting recommendations categories unclear evaluated characteristics reproductive life women increased genetic familial breast cancer risk attending family cancer center breast cancers brca mutation carriers likely hormone receptor negative diagnosed years multiple lifetime tumors women increased familial risk distribution invasive cancers positive tumors similar different risk groups least one fullterm pregnancy breastfeeding either less one year late age menopause showed protective factors brca mutation carriers women increased familial risk early age first full term pregnancy late menarche showed main protective factors finally entire population combined hormonal contraceptives demonstrated increase breast cancer risk results study suggest women high familial risk mutation carries develop tumors different clinical pathological characteristics consequently influenced different protective risk factors
paper proposes implements new single phase magnetless flux switching machine fsm rooftop wind power generation key integrate outer rotor fsm inner rotor fsm shared stator yoke stator drum windings way proposed machine realize flux switching function regulate magnetic flux effectively also incorporate field armature windings within one stator reduce copper losses improve overall machine efficiency meanwhile structure compact rotors directly driven blades capture wind power machine design guidelines magnetic electric aspects illustrated machine characteristics analyzed using time stepping finite element method system performances evaluated based mathematical modeling simulation prototyping test conducted verify validity proposed machine system
two part paper topological analysis powertrains refuse collecting vehicles rcvs based simulation different architectures internal combustion engine hybrid electric hybrid hydraulic real routes proposed second part three different hybrid electric powertrain architectures proposed modeled architectures based use fuel cells ultracapacitors batteries calculation engine specifically designed estimate energy consumption respecting original performance original internal combustion engine ice presented used simulations component sizing finally overall performance different architectures hybrid hydraulic taken first paper part hybrid electric estimated second part control strategies summarized fuel energy consumption table based table analysis different architecture performance results carried analysis technological evolution vehicles medium long terms proposed
increased anxiety stress frequently found children autism spectrum disorder associated social challenges recently reported changes social competence following peer mediated theatre based intervention purpose study examine impact intervention reducing anxiety stress participants included youth autism spectrum disorder years old randomly assigned experimental waitlist control group pretest adjusted group differences analyzed state anxiety trait anxiety play based cortisol diurnal cortisol pearson correlations conducted anxiety cortisol group play significant pretest adjusted group differences posttest observed trait anxiety state anxiety showing lower trait anxiety experimental group group differences cortisol significant negative correlation group play trait anxiety playground cortisol correlated group play experimental group theatre based peer mediated intervention contributes improvement social competence youth autism spectrum disorder also contributes reductions trait anxiety associated social interaction peers results suggest degree physiological arousal essential social interaction
present study designed examine trajectories personal identity coherence confusion among hispanic recent immigrant adolescents well effects trajectories psychosocial risk taking outcomes personal identity extremely important anchoring young immigrants time acute cultural change sample recently immigrated years less united states baseline hispanic adolescents age years baseline years range miami los angeles girls completed measures personal identity coherence confusion first five waves six wave longitudinal study reported positive psychosocial functioning depressive symptoms externalizing problems baseline time results indicated identity coherence increased linearly across time significant changes confusion time individual differences confusion trajectories higher baseline levels improvements coherence predicted higher levels self esteem optimism prosocial behavior final study timepoint higher baseline levels confusion predicted lower self esteem greater depressive symptoms aggressive behavior rule breaking final study timepoint results discussed terms importance personal identity hispanic immigrant adolescents terms implications intervention
increasing incidence prevalence antibiotic contamination animal derived food drug resistance around world early specific detection antibiotic residues garnered significant attention herein first time devise facile label free portable aptasensor quantitative determination kanamycin kana electrochemical impedance spectroscopy eis accompanying assembly vitro selected single strand dna ssdna anti kana aptamer functionalized screen printed carbon electrodes spces used transducer target detection based specific recognition kana aptamer covalently immobilized spces surface surface morphology electrochemical properties aptasensor characterized using fourier transform infrared spectroscopy scanning electron microscopy sem atomic force microscopy afm cyclic voltammetry eis optimized experimental conditions devised aptasensor exhibited dynamic range ngml linearity ngml limit detection lod kana developed aptasensor endowed good selectivity specificity kana without interference competitive analogues streptomycin gentamicin practical application aptasensor performance verified spiked milk samples acceptable recovery percentage rsd obtained milk samples elsevier rights reserved
present study undertaken study impact surgical menopause oxidant antioxidant status relation estrogen levels months surgery total women undergone total hysterectomy without bilateral salpingo oophorectomy bso included study oxidant status assessed measuring plasma levels malondialdehyde antioxidant status assessed measuring superoxide dismutase catalase glutathione glutathione peroxidase estrogen vitamin levels malondialdehyde level significantly increased women underwent without bso significant increased levels superoxide dismutase observed women underwent bso blood glutathione levels significantly decreased women significantly increased women undergone bso levels estrogen vitamin vitamin significantly decreased women underwent bso catalase gpx vitamin differ significantly groups result suggests surgical menopause associated oxidative stress reiterates fact ovaries retain function even menopause
recent years database technology widely used fields keyword search technology based relational databases require users master knowledge sql grammar database schema users need input keywords conveniently search information via keyword like internet search engines results users pleased use technology paper employee query expansion plan based query sentence propose query expansion method based thesaurus method matches key words thesaurus key word matches word thesaurus words row used synonym key word test results show recall precision ratio system satisfied needs applications
rationale endothelial dysfunction major predictor late cardiovascular events linked severity obstructive sleep apnea osa objectives determine whether treatment mandibular advancement device main alternative continuous positive airway pressure improves endothelial function patients severe osa methods trial randomized patients severe osa overt cardiovascular disease receive months treatment either effective mandibular advancement device sham device primary outcome change reactive hyperemia index validated measurement endothelial function assessed intention treat basis embedded microsensor objectively measured treatment compliance measurements main results total patients males mean age median interquartile range apnea hypopnea index mean epworth sleepiness scale randomized effective mandibular advancement device sham device intention treat analysis effective mandibular advancement device therapy associated improvement endothelial function compared sham device office ambulatory blood pressure outcomes differ two groups effective mandibular advancement device therapy associated significant improvements apnea hypopnea index microarousal index symptoms snoring fatigue sleepiness mean objective compliance night effective mandibular advancement device versus night sham device conclusions moderately sleepy patients severe osa mandibular advancement therapy reduced osa severity related symptoms effect endothelial function blood pressure despite high treatment compliance
efficiency light load converter improved reducing switching frequency load current bifrequency operation bfo using pulse train control achieve spread spectrum using discrete time models paper shows stable periodic bfo generally achievable existing control methods thereafter unified multimode digital control technique proposed voltage mode digital pulse width modulator dpwm used control predefined periodic bfo beside fixed frequency dpwm extra multiplexer considered real time configuration bifrequency pulse frequency modulation control pulse regulation control pulse skipping control smooth transition analysis design methods discussed ensure periodic bfo customize power spectrum predictable ripple parameters buck converter prototype made proposed control implemented using fpga device
recent experiments shown certain fluid mechanical systems namely oil droplets bouncing oil films mimic wide range quantum phenomena including double slit interference quantization angular momentum zeeman splitting investigate learned systems concerning theorems bell kochen specker particular model bell experiment proposed includes variables describing background field medium field mimics surface wave accompanies droplets fluid mechanical experiments appears quite generally model violate bell inequality reproduce quantum statistics even based local dynamics reason measurement independence valid models opens door local background based theories describing interaction particles analyzers background field complete quantum mechanics experiments test ideas also proposed
purpose longitudinal study investigate whether distinct etiological processes explaining dual usage alcohol conventional cigarettes mothers preconception early parenting years data biological mothers drawn early childhood longitudinal study birth cohort ecls representative births general growth mixture model ggmm used empirically identify developmental trajectories maternal smoking drinking year study period six classes defined alcohol consumption cigarette smoking identified included nonsmoking low probability drinking class two drinking classes displaying smoking either moderate escalating high probability drinking additionally two predominantly smoking classes identified one displaying temporary reduction smoking pregnancy low probability drinking one following trajectory persistent heavy smoking declining probability drinking sixth class described temporary reduction smoking pregnancy high probability drinking covariates differentially predicted class membership high school degree education predicted concurrent drinking smoking breastfeeding months protective concurrent use prior conception prenatal care post natal clinical visits whether personal pediatric care screening women reproductive age via characteristics predict heterogeneity smoking drinking trajectories may help guide prevention treatment options
introduction suggested human utero exposure heavy metals selenium reduce prevalence childhood asthma allergic diseases however data topic scarce objective present study assess putative associations maternal selenium level pregnancy risk asthma wheezing allergic rhinitis atopic dermatitis children eden birth cohort age years methods plasma selenium concentrations measured maternal blood mid pregnancy weeks gestation mothers cohort children followed birth years using health questionnaires filled parents asthma wheezing allergic rhinitis atopic dermatitis maternal plasma selenium related childhood outcomes age years results results showed significant negative association high maternal plasma selenium level pregnancy risk wheezing child age years however maternal plasma selenium pregnancy associated prevalence asthma allergic rhinitis atopic dermatitis conclusions results study suggest level fetal exposure maternal selenium could influence risk wheezing infancy potentially risk developing asthma later life
modified thermostatic control strategy applied powertrain control parallel mild hybrid electric vehicle hev improve fuel economy strategy improve fuel economy parallel mild hev operating internal combustion engine ice high efficiency region thus study experiments parallel mild hey conducted analyze characteristics hybrid electric powertrain numerical model developed vehicle based results thermostatic control strategy modified applied vehicle model also battery protection logic using electrochemical battery model applied active usage battery thermostatic control strategy damage battery simulation results vehicle urban driving conditions show thermostatic control strategy improve vehicle fuel economy compared conventional strategy results also suggest trade fuel economy improvement efficient ice operation battery life reduction active battery usage carefully investigated thermostatic control strategy applied parallel mild hev
objective volatile essential oils mint species used cosmetics skin care products study evaluated main chemical components lime mint anti melanogenic properties main components methods essential oil analysed gas chromatography mass spectrometry anti melanogenic effects mint essential oil caryophyllene investigated murine melanoma cells results main components lime mint essential oil found limonene carvone selinene caryophyllene lime mint essential oil reduced melanin production dose dependent manner murine cells caryophyllene one main compounds lime mint essential oil could reduce melanogenesis regulating expression mitf trp trp tyrosinase resulting decrease melanin content decrease conclusion results reveal lime mint essential oil caryophyllene considered valuable potential skin whitening agents
study aimed provide insights perceptions engineering students two educational paths singapore desired graduate attributes employers research questions graduates polytechnic junior college paths similar perceptions regard ranking desirable graduate attributes ways perceptions different literature review review literature employers ranking desirable graduate attributes revealed mismatches employers graduates rankings published study student awareness employability skills singapore particular hence study investigated perceptions final year engineering students two different educational paths ranking graduate attributes methodology students asked rank eight attributes explain ranking employer perspective results findings show communication teamwork problem solving ranked top three desirable attributes groups students however polytechnic students seem reflect greater familiarity confidence tackling workplace requirements compared junior college students implications findings presented
objective hospital acquired pressure ulcers hapus mortality rate costly treat result medicare reimbursement penalties medicare codes hapus according agency healthcare research quality patient safety indicator psi sometimes inappropriately coded objective use electronic health records predict pressure ulcers identify coding issues leading penalties materials methods evaluated hospitalized patient electronic medical records academic medical center data repository data contained patient encounter level demographic variables diagnoses prescription drugs provider orders hapus defined psi stages iii unstageable pressure ulcers present admission secondary diagnosis excluding cases paralysis random forests reduced data dimensionality multilevel logistic regression patient encounters evaluated associations covariates hapu incidence results approach produced sample population patients psi cases greatest odds ratio hapu incidence among patients diagnosed spinal cord injury icd spinal cord injuries properly coded paralysis leading psi flag high ors included bed confinement icd provider ordered pre albumin lab discussion analysis identifies spinal cord injuries high risk hapus often inappropriately coded without paralysis leading psi flags resulting statistical model tested predict hapus hospitalization
paper reports free breathing black blood cine fast spin echo fse technique measuring abdominal aortic wall motion free breathing cine fse includes following techniques variable density sampling fast iterative reconstruction inner volume imaging blood suppression preparation pulse proposed technique evaluated eight healthy subjects inner volume imaging significantly reduced intraluminal artifacts respiratory motion quantitative measurements diameter wall distensibility anterior posterior walls respectively cyclic cross sectional distensibility greater systolic phase diastolic phase conclusion developed feasible cine fse method measure motion abdominal aortic wall enable clinical scientists study elasticity abdominal aorta
background antimicrobially pre treated children systemic inflammation often pose diagnostic challenge physician aimed evaluate additional use septifast multiplex polymerase chain reaction pcr identify causative pathogens children suspected systemic bacterial fungal infection methods prospective observational study children systemic inflammatory response syndrome sirs empiric antibiotic treatment primary outcome rate positive blood cultures compared rate positive septifast results results total samples yielded positive results compared positive blood cultures positive tests considered infection median time positive days time definite result days compared antimicrobial therapy adapted patients positive septifast patients positive best predictive power positive shown receiver operating characteristic demonstrated procalcitonin pct area curve auc compared reactive protein crp auc leukocyte count auc procalcitonin threshold yielded sensitivity specifity children positive septifast result day significantly higher risk require treatment pediatric intensive care unit deceased day odds ratio conclusions additional testing septifast antimicrobially pre treated children systemic inflammation enhances rate pathogen detection influence multiplex pcr clinically relevant outcome parameters evaluated
paper investigates effects different factors performance nonlinear model updating seven story shear wall building model accuracy calibrated models using different data features modeling assumptions studied comparing time frequency responses models exact simulated ones simplified nonlinear finite element models shear wall building calibrated misfit considered response data features models structure minimized refined model test structure calibrated manually match shake table test data used instead real structure performance evaluation study simplified parsimonious models composed simple nonlinear beam column fiber elements nonlinearity infused assigning generated hysteretic nonlinear material behaviors uniaxial stress strain relationship fibers four different types data features combinations used model calibration time varying instantaneous modal parameters displacement time histories acceleration time histories dissipated hysteretic energy observed calibrated simplified models accurately predict nonlinear structural response absence significant modeling errors last part study physics based models simplified casting state space formulation real time identification performed using unscented kalman filter shown performance calibrated state space models satisfactory reasonable modeling assumptions used elsevier ltd rights reserved
integrating knowledge environmental degradation biodiversity change ecosystem processes across large spatial scales remains key challenge illuminating resilience earth systems growing realization manner communities respond anthropogenic impacts ultimately control ecosystem consequences examine response freshwater fishes nutrient excretion key ecosystem process control aquatic productivity human land development across contiguous united states linking continental scale dataset fish species stream locations species functional traits nutrient excretion land remote sensing present four key findings first provide first geographic footprint nutrient excretion freshwater fishes across united states reveal distinct local continental scale heterogeneity community excretion rates second fish species exhibited substantial response diversity sensitivity land development native species tolerant species also species contributing greater ecosystem function terms nutrient excretion third modeling increased land use change resultant shifts fish community composition land development estimated decrease fish nutrient excretion majority ecoregions fourth loss nutrient excretion would greater biodiversity loss random greater nonnative species thus ecosystem processes sensitive increased anthropogenic degradation biotic communities provide multiple pathways resistance resistance varies across space
bycatch mortality significant driver marine mammal population declines however little information available patterns magnitude bycatch mortality many heavily fished asian marine systems south china sea scs address limited knowledge base conducted interviews fishers gather local ecological knowledge marine mammal bycatch around hainan island china gillnets primary fishing gear used local fisheries also responsible majority reported marine mammal bycatch events recent decades bycatch events reported seasons frequent spring might relate seasonal variation fishing activities spatial pattern relative bycatch densities indo pacific humpback dolphins indo pacific finless porpoises unidentified small dolphins varied around hainan neighbouring waters substantial proportion informants respectively reported eaten sold marine mammal meat demonstrating continued existence cultural practices consuming marine mammals hainan responses fishers bycatch events dependent existing attitudes perceptions towards marine mammals sociocultural factors almost half informants agreed marine mammal populations scs decreased declines thought informants caused overfishing water pollution vessel collisions bycatch responsible declines dolphins
within diagnostic process activities digital radiology systems utilised image display devices play important role devices guarantee high performances order maintain diagnostic quality displayed images present observed optimally order ensure appropriate performance users image display device also whole workstation designed properly particular attention paid lighting conditions avoid compromising radiologist ability observe displayed images aim study assess lighting workstations used diagnostic radiology reporting order obtain information visual interaction worker device prevent health risks detailed analysis lighting adjustable nonadjustable workstations used diagnostic radiology reporting carried different rooms radiology department felice lotti hospital pontedera pisa italy analysis carried thanks situ measurements objective analysis submission evaluation questionnaire sample composed radiologists subjective analysis obtained results possible point nonadjustable workstations absence dedicated lighting system often reveals inadequacy general lighting guaranteeing correct lighting conditions radiologists reading diagnostic monitors measure reduce visual fatigue radiologists use supplementary adjustable innovative led backlight system proposed use led backlight system allows complying requirements technical standards mitigate difference luminance field view radiologist due use led backlight system positively perceived examined sample significant part ascribed use reduction visual fatigue elsevier rights reserved
efforts fight diet related diseases raising health consciousness markedly ineffective attempts often paternalistic normative provide less intrusive approaches paper reports five mixed methods studies explore health supportive side effects motives unrelated health qualitative study identifies quality consciousness physical appearance consciousness potential candidates health supportive side effects study applies implicit association test unravel quality physical appearance implicitly associated less healthy foods study corroborates side effects health unrelated motives healthy lifestyles healthy food consumption study demonstrates side effects particularly powerful consumers low health consciousness study study externally validate side effects actual choices shopping cart composition overall side effects provide new avenues nudge food shoppers towards healthier consumption patterns yet avoid unintended negative effects fostering eating disorders emphasizing physical appearance consciousness interventions planned carefully elsevier ltd rights reserved
article deals development application snake robot inspection pipes first step involves introduction design mechanical electrical parts snake robot next analysis robot locomotion introduced curved pipe potential field method used method system able generate path head rear robot linking environment obstacles represented walls pipe subsequently solution potential field method used inverse kinematic model respects tasks obstacle avoidance joint limit avoidance singularity avoidance mentioned approach tested snake robot provisional pipe rectangular cross section research software matlab used control system cooperation control system robot based microcontrollers experiments shown designed robot able pass straight also curved pipe
heroes ubiquitous literature popular discourse yet little known cognitive representations heroes examined lay conceptions heroes using prototype approach compared heroes persons influence studied individuals use hero features identify heroes study participants generated open ended descriptions heroes sorted independent coders meaningful categories study participants rated centrality features subsequently classified feature either central brave moral integrity peripheral humble proactive reaction time paradigm participants study identified central features heroes faster peripheral features study participants remembered central hero features peripheral features surprise recall task study participants strongly identified hero target described central features peripheral neutral features studies participants ratings evidenced prototypical features heroes fit conceptually well role models leaders studies contribute new ideas existing knowledge heroes contribute shared understanding hero means people research thus important step refining heroism scientific concept notion prototypical features heroes provides basis future hero research intervention
mindfulness increasingly important part clinical case conceptualization treatment mental illness although links mindfulness psychiatric symptoms mindfulness functioning well established relatively studies examine unique contributions mindfulness symptoms functioning concurrently moreover found studies examining mindfulness symptoms functioning using faceted measures mindfulness one thousand ninety nine psychiatric outpatients bariatric surgery candidates completed five facet mindfulness questionnaire ffmq medical outcomes study item short form health survey structured clinical interview dsm scid also included items schedule affective disorders schizophrenia sads pearson correlations suggested four five mindfulness facets observe act awareness nonjudge nonreact related consistently psychiatric symptoms functional outcomes psychiatric bariatric samples psychiatric sample act awareness indirect effect functioning nonjudge nonreact indirect direct effects functioning symptoms contrast bariatric sample showed direct indirect effects act awareness nonjudge nonreact symptoms functioning single direct effect observe physical functioning fifth facet describe dropped models taken together results suggest mindfulness facets vary significantly relation psychiatric symptoms functioning results implications conceptualizing mindfulness mindfulness based interventions clinical research settings
objective aimed study characteristics child mother reported parenting styles children attention deficit hyperacitivity disorder adhd association parenting styles mothers demographic clinical variables like adhd symptoms sex age adhd subtype comorbidity method children adhd healthy children included study children assessed schedule affective disorders schizophrenia school aged childrenpresent lifetime version adhd symptom severity assessed conners parent rating scale conners teacher rating scale parenting style inventory psi parental attitude research instrument pari used assess parenting styles mothers results adhd group lower scores two subscales psi acceptance involvement strictness supervision democratic attitude equality subscale pari higher scores strict discipline subscale pari compared control group adhd group higher symptoms oppositional defiant disorder associated higher mother strict discipline scores lower child reported mother acceptance involvement scores conclusion findings supported idea may association parenting attitudes adhd symptoms families child adhd results indicated importance integrated approach adhd diagnosis treatment evaluating child adhd context family environment
objectives sought estimate prevalence eating disorder symptoms large sample college students variations therein across student characteristics methods participants students colleges universities participating healthy bodies study used gender stratified logistic regression estimate bivariate correlates elevated eating disorder symptoms past month objective binge eating past month compensatory behaviors across student characteristics including age degree level sexual orientation race ethnicity first generation status citizenship academic extracurricular characteristics weight status eating disorder outcomes based eating disorder examination questionnaire results observed higher prevalence objective binge eating among females relative males versus similar prevalence compensatory behaviors vdrsus weight status consistent predictor eating disorder risk significantly symptoms seen among individuals overweight obesity compared individuals healthy weight overweight greater eating disorder risk males females binge eating males females use compensatory behaviors males females conclusions study suggests smaller gender difference prevalence eating disorder symptoms previously reported identifies students overweight obesity salient targets campus based eating disorder screening early intervention efforts elsevier ltd rights reserved
natural source electromagnetic methods potential recover rock property distributions surface great depths unfortunately results complex geo electrical settings disappointing especially significant near surface conductivity variations exist settings unconstrained inversion magnetotelluric data inexorably non unique believe correctly introduced information seismic reflection substantially improve inversion cooperative inversion approach automated massively parallel computing make process viable nine inversion strategies including baseline unconstrained inversion new automated semiautomated cooperative inversion approaches applied industry scale located seismic magnetotelluric data sets data sets acquired one carlin gold deposit districts north central nevada usa approach seismic information feeds directly creation sets prior conductivity model covariance coefficient distributions demonstrate statistical analysis distribution selected seismic attributes used automatically extract subvolumes form framework prior model conductivity distribution cooperative inversion strategies result detailed subsurface conductivity distributions consistent seismic electrical logs geochemical analysis cores conductivity distributions would expected provide clues velocity structures could feed back full seismic inversion iterative practical truly cooperative inversion process anticipate aid parallel computing cooperative inversion seismic magnetotelluric data fully automated hold confidence significant practical advances direction accomplished
motions suspension bridge immersed turbulent wind flows including mean stochastic certain conditions lead degradation structure torsional stiffness ensuing aerodynamic torsional divergence atd incompressibility main cables determines effectiveness supporting members limited tension state dropping either one cable tension state could result vanish torsional stiffness contributed whole cable system although physical conception quite explicit evaluation critical threshold atd suspension bridge experiencing stochastic aerodynamic responses complicated deformations towers lateral oscillations deck cables high order modes participating vibration view criterion based tracking length main cables presented study shown numerical example advent atd degradation system stiffness well striking post atd behaviors well explained proposed model tracking cable lengths elsevier ltd rights reserved
background xanthogranulomas uncommon granulomatous entities xanthogranulomas occurring sellar region extremely rare limited number cases reported literature diagnosis management prognosis sellar xanthogranulomas poorly understood methods retrospectively reviewed patients histologically proven sellar xanthogranulomas treated institution january july clinical manifestations radiologic features operative records follow outcomes analyzed results male female patients mean age years clinical manifestations included headache visual deficiencies endocrine disturbances magnetic resonance imaging sellar xanthogranulomas revealed isointensity hyperintensity weighted imaging hyperintensity heterogeneous intensity weighted imaging variable enhancement gross total resection lesion achieved cases subtotal resection achieved cases post operatively headache relieved cases transient diabetes insipidus observed cases procedure related complications mean follow period months visual deficiencies improved cases whereas endocrine disturbances improved cases recurrence regrowth residual lesions observed conclusions sellar xanthogranuloma considered differential diagnosis lesions sellar region radiologic characteristics including hyperintensity weighted imaging heterogeneous hyperintensity weighted imaging variable enhancement absence calcification assist making preoperative diagnosis surgical outcomes favorable
several countries promulgated control measures design guidelines limit proliferation legionella within hot water distribution systems hwds however little information assess improve existing hwds unable maintain water temperatures degrees throughout system year old hot water system story hospital investigated terms temperature distribution legionella pneumophila prevalence concentrations pneumophila correlated maximum temperature reached tap significant decrease observed degrees continuous temperature flow monitoring performed overall hwds characterizing principal secondary horizontal return loops wings detailed investigations secondary vertical return loops completed wing results indicated system inability systematically maintain desired operating temperatures degrees deficient hydraulic distribution root cause poor temperature maintenance throughout secondary loops defective devices also identified playing important role sectorial temperature failure simple stepwise investigative approach developed identify hydraulic deficiencies implementation flow restrictions identified recirculation loops increased pumping efficiency conducted within short period months major system upgrade corrective measures resulted balanced system increased flow velocities result proportion taps achieving degrees within min increased pneumophila prevalence decreased weeks authors published elsevier ltd
wireless data transmissions processes data loss important factor reduces robustness wireless sensor networks wsns many practical engineering applications data loss compensation algorithms required maintain robustness algorithms typically based compressive sensing large memory microcontrollers needed paper presents improved algorithm based random demodulator overcome difficulty microcontroller dependence traditional data loss algorithms newly developed algorithm demonstrates following advantages low space complexity low floating point calculations low time complexity therefore suitable embedded ordinary nodes comparing traditional algorithms paper wsn based wifi also developed verifying effectiveness feasibility proposed algorithm field experiment xinghai bay bridge done experimental results show wsn works properly steady moreover data loss compensated effectively efficiently use present algorithm
introduction neonatal infantile skin diseases frequently encountered clinical practice represent worldwide socioeconomic issue encompass wide range acquired congenital conditions including infections vascular lesions inflammatory diseases present different degrees severity leading cases dramatic complications areas covered paper report recent evidences management common skin diseases neonates infants hemangiomas viral fungal bacterial infections omphalitis atopic seborrhoeic dermatitis napkin disease treated discussed expert opinion majority dermatologic alterations neonates physiological transient require treatment thus parents reassured good prognosis however cases serious conditions must excluded particular neonatal infantile infections promptly recognized properly managed avoid severe complications therapeutic options include traditional although innovative medical treatments carefully taken consideration expert dermatologists paediatricians
real life utility networks smart grids pipelines water networks exposed safety security related risk mitigate risks might result service interruptions users networks countermeasures applied paper decision model proposed assumes edges pipes cables nodes switching connection stations substations electricity network certain probability failing reduced applying appropriate security strategies optimization model developed determines optimal security strategy applied node arc minimize probability disconnected node pairs arise network subject budget constraint metaheuristic approach solve problem proposed metaheuristic calibrated statistical experiment detailed experiments realistic instances confirm performs well
mushroom production one biggest solid state fermentation industries world success mushroom planting depends control temperature humidity parameters paper presents novel method modeling environment mushrooms growth comparing performance two controlling methods fuzzy logic digital control controlling mentioned parameters production rate controllers equipment developed data collection analysis parameters performed using simulink part matlab software precise control parameters involved growth mushrooms caused improve product quality reduced energy consumption results tests mean value obtained two different methods showed fuzzy controlling least standard deviation variance error better digital controlling fuzzy controlling system lowest fluctuation lowest band pass according gradient graph maximum minimum results conclude fuzzy controlling shown better response controlling process based number actuators mode changing systems understood digital control system downtime depreciation energy consumption would higher fuzzy control system elsevier ltd rights reserved
information sources relational databases spreadsheets xml json web apis contain tremendous amount structured data leveraged build augment knowledge graphs however rarely provide semantic model describe contents semantic models data sources represent implicit meaning data specifying concepts relationships within data models key ingredients automatically publish data knowledge graphs manually modeling semantics data sources requires significant effort expertise although desirable building models automatically challenging problem related work focuses semantic annotation data fields source attributes however constructing semantic model explicitly describes relationships attributes addition semantic types critical present novel approach exploits knowledge domain ontology semantic models previously modeled sources automatically learn rich semantic model new source model represents semantics new source terms concepts relationships defined domain ontology given sample data new source leverage knowledge domain ontology known semantic models construct weighted graph represents space plausible semantic models new source compute top candidate semantic models suggest user ranked list semantic models new source approach takes account user corrections learn accurate semantic models future data sources evaluation shows method generates expressive semantic models data sources services minimal user input precise models make possible automatically integrate data across sources provide rich support source discovery service composition also make possible automatically publish semantic data knowledge graphs elsevier rights reserved
paper modified nonlocal means denoising means algorithin proposed rolling element bearing fault diagnosis although nonlocal means denoising widely used image processing algorithm rarely used signal processing present work deals application nonlocal means denoising method enhancement fault signature rolling element bearings parameters means method obtained maximizing kurtosis value bearing vibration signal proposed method compared minimum entropy deconvolution med technique results indicate proposed method performs better bearing fault diagnosis method shown robust various noise levels envelope spectrum bearing vibration signal also used obtain characteristic bearing defect frequencies elsevier ltd rights reserved
theory research psychopathy construct increased dramatically past decades international instrument choice clinical forensic assessment construct basic neuroscience research criminal justice system psychopathy checklist revised pcl hare psychometric properties structure correlates well known article present new findings first order factors pcl interpersonal affective lifestyle antisocial used good effect understanding nature psychopathy predicting variables interest criminal justice system colleagues used variable centered approach structural equation modelling show factors make unique contributions prediction violence treatment outcome institutional behaviour forth used person oriented approach latent profile analysis lpa identify factor profiles among offenders high pcl scores manipulative psychopaths aggressive psychopaths sociopaths view variants psychopathy subtype offender also conducted lpas entire samples offenders high scores across several large diverse samples consistently identified profiles factor scores identified psychopath callous conning offender sociopath general offender finally briefly addressed issues related potential misuse pcl legal context field reliability pcl adversarial allegiance effects associated use
aim paper develop two three dimensional stability charts slopes susceptible translational failure extensive parametric study conducted using slope model designed simulate field conditions respect configurations sliding mass unit weight shear strength involved materials slopes subjected different conditions pore water pressures seismic forces considered study study shows special importance difficulties considering end effects analysis translational slope failures suggests method quantifying incorporating charts presented paper require iterative procedure determining factor safety give practicing geotechnical engineer fast reliable method estimate two three dimensional factors safety slopes susceptible translational mode failure back calculate mobilized shear strength materials involved slope failures following mode numerical examples given illustrate different uses charts
difficulties interpersonal relationships associated wide range psychiatric diagnoses reported trigger suicidal behavior aim study examine relationship interpersonal problems family history suicide suicide attempters describe relevant patterns interpersonal problems patient group study involves patients clinical follow suicide attempt family history suicide assessed using karolinska self harm history interview retrieved patient records inventory interpersonal problems used assess personal style interpersonal context suicide attempters family history suicide significantly often intrusive personal style results remained significant adjustment personality disorder specific interpersonal patterns associated family history suicide may interfere ability create stable long lasting relationships regards treatment personal qualities could cause difficulties alliance health care personnel make harder suicide attempters accept benefit treatment attention suicide attempters interpersonal problems importance lower distress
drawing upon recent resurgence biological criminology several studies highlighted critical role genetic factors ontogeny antisocial violent conduct particular converging lines evidence documented maladaptive manifestations aggression influenced monoamine oxidase maoa enzyme catalyzes degradation brain serotonin norepinephrine dopamine interest link maoa aggression originally sparked han brunner discovery syndrome characterized marked antisocial behaviors male carriers nonsense mutation gene subsequent studies showed maoa allelic variants associated low enzyme activity moderate impact early life maltreatment aggression propensity spite overwhelming evidence pointing relationship maoa aggression neurobiological substrates link remain surprisingly elusive little also known interventions may reduce severity pathological aggression genetically predisposed subjects animal models offer unique experimental tool investigate issues particular several lines transgenic mice harboring total partial loss function maoa mutations shown recapitulate numerous psychological neurofunctional endophenotypes observed humans review summarizes current knowledge link maoa aggression particular emphasize integrated translational strategy coordinating clinical preclinical research may prove critical elucidate important aspects pathophysiology aggression identify potential targets diagnosis prevention treatment elsevier inc rights reserved
article draws historical explorers accounts ethnography organisational approaches examine practices discourses perceptions leadership prototypical indigenous communities west central africa highlights leadership meanings context differ anglo centric thinking writings key contribution unravelling ways historical cultural hegemonies impose particular discursive formations constructed practices mind programming non anglo saxon socio cultural context dramaturgical power arrangement lucid role substitution notion leadership non human emerge dominant themes analysis also featuring significantly representations leadership symbols mythology transcendental metaphysical conceptualisations different predominant anglo saxon writings frequently present leadership linear hierarchies dyadic leader follower relationship acts behaviours heroic figures essentially human action afro centric indigenous concept leadership reflecting context proposed challenges heroism linearity individualism objectivism
use white light based three fringe photoelasticity tfp rgb photoelasticity gained importance recent years recent advances tfp possible resolve fringe orders upto twelve main advantage technique requires single image isochromatic demodulation makes suitable especially problems recording multiple images difficult accuracy isochromatic data obtained using tfp rgb photoelasticity dependent scanning scheme used refine data necessary incorporate fringe order continuity paper existing scanning schemes critically evaluated ability scan entire model domain influence seed point selection noise propagation scanning schemes assessed using four problems increasing level geometric complexity circular disc compression simply connected axially loaded cruciform specimen inclined crack thick ring subjected internal pressure finite plate hole multiply connected elsevier ltd rights reserved
conventional methods obtain solar radiation data weather stations solar radiation models commercial software databases field measurements studies presented compare results four mentioned methods considering new daily diffuse solar radiation models northern china climates first established study solar radiation models compared open access weather station data china meteorological data sharing system cmdss trnsys database data measured data trnsys supplies typical meteorological year data solar radiation models give long term annual average results found combining sunshine duration day year together establish group accurate diffuse solar radiation models good agreements found cmdss newly established solar radiation model calculating daily diffuse solar radiation diffuse solar radiation estimated trnsys bit higher open access website summer half year trnsys supplies highest annual diffuse solar radiation trnsys database high significance solar system performance evaluation solar radiation models used solar system design elsevier ltd rights reserved
osteochondral defects impingement instability ankle common injuries athletes article review diagnoses treatment options focus arthroscopic approaches treatment options continue evolve supported innovation outcome studies article describe advantages disadvantages open arthroscopic treatments using published evidence
current study investigates descriptive prescriptive gender norms communicate work family identities compatible gender identities limit enhance young men womens family career aspirations results show young adults perceived gender norms assign greater compatibility female family identities male work identities vice versa young men women mirror aspirations traditional division tasks spill effects norms across life domains cross effects norms across gender groups indicated young women young men aimed mirroring career ambitions male career model keeping family aspirations high moreover young women opposed traditional role divisions family domain decreasing family aspirations face norms lower family involvement higher career involvement men conversely line traditional gender roles young men showed lower family aspirations face strong male career norms showed increases career aspirations perceiving women take family roles young mens family aspirations however influenced new norms prescribing men invest family suggesting opportunities change together findings show social norms young adults gender identity affects aspirations manage presence work family identities altering norms may provide leverage change allow men women combine multiple identities enriching way
sexual gender norms promoting sexual prowess men sexual modesty women shown negatively affect sexual mental health men women knowledge relationship gender norms sexual cognitions emotions might understanding continued gender norm conformity present study investigated whether gendered sexual attitudes related positive negative sex related emotions via sexual cognitions autonomy body esteem approach avoidance motives sex survey submitted heterosexually identified sexually active dutch central southern regions year olds results moderated mediation model using structural equation modeling revealed women men strongly endorsed traditional gender related sexual attitudes experienced significantly less positive negative emotions result decreased sexual autonomy sexual body esteem well increased avoidance motives sex conclude result negative cognitions associated endorsement traditional gender norms women particular risk experiencing negative emotional outcomes sexual context argue sexual cognitions emotions deserve explicit attention sex positive gender transformative sexuality education proven vital resource achieving increased gender equity sexual romantic relationships
synergy satellite terrestrial mobile networks regarded promising approach delivery broadcast multicast services mobile users paper evolves around hybrid satellite terrestrial system featuring unidirectional satellite component responsible delivery point multi point services proposes systematic approach satellite system capacity partitioning streaming push store services radio bearer configuration within satellite access layer approach takes account service requirements estimates traffic demand popularity individual services preliminary link dimensioning exercises capacity analysis carried end check efficiency approach concluding time feasibility hybrid system solution
volcanosedimentary boron deposits formed specific volcano lake facies deposition environment neogene period characteristic boron bearing stratum containing boron lacustrine sedimentary rocks tuff andesite volcanic rocks interbedded cyclically composed binary sedimentary structure borate mineral deposition occurred late deposition period usually associated tuff clay limestone formed boron deposits characteristics low density low electrical resistivity according characteristic boron deposits employ comprehensive geophysical technology exploration firstly conducted high precision gravity survey xiongba area tibet obtain bouguer gravity anomalies processing analysis gravity data got access fault structures development gravity anomaly changes study area deduced spatial variation characteristics underground lithology delineated favorable mining area volcanosedimentary boron deposits based audio magnetotelluric sounding carried favorable area electrical structure characteristics underground strata study area obtained combining seismic electric fitting electrical data joint inversion gravity electricity data geological data study area analyzed stratum structure fracture system distribution sedimentary rocks relation volcanosedimentary boron deposits predicted distribution volcanosedimentary boron deposits drilling test results basically consistent predicted results
phase transformation induced resistive switching behavior cuse device studied device demonstrate resistive switching behavior room temperature exhibited resistive switching behavior degrees near transition temperature copper selenide cuse degrees cuse known transform monoclinic superionic phase increase ionic conductivity structural variations ordered disordered structure associated phase transformation observed responsible origin switching behavior increase resistance ratio near transition temperature thermodynamic calculations showed reduction gibb free energy nucleation increase migration speed ion associated ionic conductivity order disorder transition cuse transition temperature important factors responsible reduction set voltages degrees
assist rehearsal planning robot assisted partial nephrectomy real time simulation platform presented allows surgeons visualise interact rapidly constructed patient specific biomechanical models anatomical regions interest coupled framework volumetric deformation platform furthermore simulates intracorporeal ultrasound image acquisition using preoperative imaging data source facilitates planning optimal transducer trajectories viewpoints also act validation context manually operated freehand acquisitions reconstructions simulation platform implemented within gpu accelerated nvidia flex position based dynamics framework order validate model determine material properties simulation parameter values porcine kidney embedded fiducial beads scanned segmented acquisitions rest position three different levels probe induced deformation collected optimal values cluster stiffness coefficients determined range different particle radii objective function comprised mean distance error real simulated fiducial positions sequence deformations mean fiducial error deformation stage found compatible level ultrasound probe calibration error typically observed clinical practice furthermore simulation exhibited unconditional stability account use clustered shape matching constraints novel position based dynamics implementation soft tissue deformation shown facilitate several desirable simulation characteristics real time performance unconditional stability rapid model construction enabling patient specific behaviour accuracy respect reference images
twelve single chambered air cathode tubular microbial fuel cells tmfcs filled fruit vegetable residues anodes realized means carbon fiber brush cathodes realized graphite based porous ceramic disk nafion membranes dupont performances terms polarization curves power production assessed according different operating conditions percentage solid substrate water dilution adoption freshwater naci water solution finally effect initial potentiostatic growth tmfcs operated low amendment carried despite harsh environmental conditions tmfcs showed power density ranging waste maximum waste referred cathodic surface cod removal day period remarkably low values well fouling nafion membrane likely limited tmfc performances however scale estimation reactors provides interesting values terms power production compared actual anaerobic digestion plants results encourage studies characterize graphite based porous ceramic cathodes optimize global tmfc performances may provide valid sustainable alternative anaerobic digestion technologies elsevier ltd rights reserved
theories analyzing stresses strain laminated structures assessment strength briefly reviewed actual practice realistic assessment strength many cases still challenge general different failure modes composite laminates compete addition laminate structures situations highly localized stresses frequently occur assessed employing pure stress based strength materials approach sometimes stress localizations along high finite stress concentration sometimes goes along stress singularities within scope elasticity theory means infinitely high stresses promising way predict effective strength cases use hybrid failure criteria within framework finite fracture mechanics approach also considered present article
recent years link diet disease become well established studies increasingly pointing role diet disease prevention well ability prevent chronic diseases affecting children consequence ever functional products specifically targeting children marketed terms benefits conferred children health well potential reducing risk disease current study aims explore factors affecting parents choices suitable ffs children questions addressed paper concern ffs children perceived parents driving factors affect willingness purchase ffs results web survey conducted southern italy sample parents children aged years reveal parents strong interest functional nutrition children even level familiarity products still low furthermore multivariate analysis shows buying frequency ffs targeting children influenced several variables beyond socio demographics generally related parents nutritional knowledge trust familiarity ffs paper provides practical indications policy makers marketers build different strategies improve communication nutritional health benefits ffs children
paper analyses application two fault tolerant control schemes hydroelectric model developed matlab simulink environments proposed fault tolerant controllers exploited regulating speed francis turbine included hydraulic system nonlinear behaviour hydraulic turbine inelastic water hammer effects taken account order develop high fidelity simulator dynamic plant first fault tolerant control solution relies adaptive control design exploits recursive identification linear parametric time varying model monitored system second scheme proposed uses identification fuzzy model exploited reconstruction fault affecting system diagnosis way fault estimation accommodation possible note strategies based identification approaches suggested enhancing application suggested fault tolerant control methodologies characteristics study represent key issues line implementations considered viable application proposed fault tolerant control schemes faults considered paper affect electric servomotor used governor hydraulic turbine speed sensor hydraulic turbine system imposed separately simultaneously moreover complete drop rotational speed sensor also analysed monte carlo simulations also used analysing important issues proposed schemes presence parameter variations moreover performances achieved means proposed solutions compared standard pid controller already developed considered model finally strategies serve highlight potential application proposed control strategies real hydraulic systems elsevier ltd rights reserved
objective many women undergo menopausal transition paid employment effect poor working conditions women experience menopause received scant empirical attention examined associations employment conditions work related stressors menopausal symptom reporting among perimenopausal postmenopausal working women methods data drawn online survey conducted involving perimenopausal postmenopausal women working higher education sector australia survey questions assessed demographics health related variables menopausal symptom reporting employment status presence flexible working hours presence temperature control job autonomy supervisor support results forced entry multivariable regression analysis revealed high supervisor support beta employed full time basis beta control workplace temperature beta independently associated lower menopausal symptom reporting conclusions findings may help inform development tailored occupational health policies programs cater needs older women transition menopause workplace
study aimed evaluate variation following parameters rotation motor pump set power developed electric motor reduction energy consumption pumping set center pivot irrigation system operating two programming levels frequency inverter three positions operation experimental design completely randomized made three replications tested position applied analysis variance followed tukey test two operation conditions tested test constant pressure output motor pump set test variable rotation accordance need pressure system condition operation tested three positions lines collecting incline level slope results showed lateral line position significantly influenced rotation motor pump set consequently power developed engine power consumption mainly test condition showing frequency inverter operating mode
vertical slot fishways structures facilitate energy dissipation using specific pool slot baffle design structures common west china develop effective simple design flow patterns pools must fish friendly assist design optimisation three dimensional computational fluid dynamics cfd model experimental study validating model using equivalent scale physical model conducted paper presents results detailed hydraulic structures including velocity fields flow patterns recirculating flows turbulent structures pool conditions slopes new structure long shaped baffle new structure effectively improve flow patterns fish adopting burst coast mode mainstream velocity decreases average proportion recirculation region decreases compared slope creates omega shaped flow pattern results provide insight flow patterns vertical slot fishways used guide future designs international association hydro environment engineering research asia pacific division published elsevier rights reserved
purpose determine long term outcomes site phacoemulsification combined fornix based trabeculectomy using mitomycin mmc primary angle closure glaucoma pacg primary open angle glaucoma poag asian population methods reviewed records patients poag pacg underwent phacoemulsification trabeculectomy using mmc january december tertiary ophthalmology unit singapore primary outcome measure cumulative success rates defined complete intraocular pressure iop mmhg without medication qualified iop mmhg least medication success results total eyes poag pacg included female mean age years respective year qualified success rates iop mmhg corresponding complete success rates mean year postoperative iop mmhg iop reduction significantly greater pacg poag eyes surgery mean number medications significantly reduced visual acuity significantly improved occurrence postoperative complications higher number topical medications younger age presence diabetes mellitus significant risk factors surgical failure conclusion two site phacoemulsification combined fornix based trabeculectomy using mmc good surgical approach asian eyes concomitant mild moderate primary glaucoma cataracts
currently estimated billion people globally non alcoholic fatty liver disease nafld condition liver fat exceeds liver weight absence significant alcohol intake due central role liver metabolism prevalence nafld increasing parallel prevalence obesity insulin resistance risk factors metabolic diseases however contribution liver fat risk type diabetes mellitus cvd relative ectopic fat depots risk markers unclear various studies suggested accumulation liver fat reduced prevented via dietary changes however amount liver fat reduction would physiologically relevant timeframes dose effect relationships achieving different diet based approaches unclear also still uncertain whether changes liver fat per associated metabolic changes relevant furthermore methods available measure liver fat even individual fatty acids differ sensitivity reliability present report summarises key messages presentations different experts related discussions workshop intended capture current views research gaps relating points
former studies suggest core features psychopathy namely callous unemotional traits associated emotional dysfunction characterized atypical processing people distress using dimensional approach traits current study aims test neural activity performance facial expression recognition task community sample young adults forty one participants females age completed inventory callous unemotional traits functional magnetic resonance imaging data collected measure neural responses fearful happy sad faces compared neutral facial expressions region interest analyses revealed exposure fearful face expressions blood oxygenation level dependent responses negatively associated traits right anterior cingulate gyms accg amygdala findings support traits related unique neural response fearful faces noncriminal population well also highlights importance taking account regions outside amygdala particular acc testing relation traits fear response authors published elsevier ltd open access article license
solar radiation data critical design operation solar energy utilization systems large number models proposed developed estimate solar radiation past ten years however performances models controversial different studies lack systematic comparison among addition studies pay attention time scales practicability models paper focuses solving questions critical literature review authors believe benefit researchers perform investigations solar radiation paper reviews compares models points view time scale estimation type first time furthermore large amount data evaluation metrics root mean square error mean absolute percentage error different studies summarized clarify performances proposed models questions arising processing source data also carefully examined paper presented novel method compare estimation models provided detailed analysis available models results indicate sunshine duration fraction models artificial neural networks similar performances used estimate monthly average daily global radiation daily global radiation work needed study estimation method smaller time intervals mechanisms atmospheric attenuation solar radiation
conducted study clinical presentation outcome patients avoidant restrictive food intake disorder arfid aged years compared group anorexia nervosa group japanese sample retrospective chart review completed patients feeding eating disorders feds analyzing prevalence clinical presentation psychopathological properties outcomes using dsm criteria patients fed met criteria arfid entry patients arfid women terms eating disorder symptoms patients arfid restrictive eating related emotional problems gastrointestinal symptoms however none arfid patients reported food avoidance related sensory characteristics functional dysphagia additionally none exhibited binge eating purging behaviors none reported excessive exercise arfid group significantly shorter duration illness lower rates admission history less severe psychopathology group arfid group reported significantly better outcome results group results suggest patients arm study clinically distinct somewhat different pediatric patients arfid previous studies elsevier ltd rights reserved
parkinson disease neurodegenerative condition caused age related death dopaminergic neurons substantia nigra mitochondrial dna mtdna deletions rise exponentially age humans reach highest levels approaching dopaminergic neurons substantia nigra overlap dying neurons parkin deletion causes parkinsonism humans presumably decrease mitochondrial quality control parkin knockout mice neurodegeneration crossed parkin knockouts twinkle mouse mtdna deletions increased specifically substantia nigra determine effect increased deletion mutagenesis absence mitochondrial quality control double mutant twinkpark mice highest mtdna deletion concentration lowest mitochondria function membrane potential severe neurobehavioral deficits months least dopaminergic neurons lowest dopamine levels parkinsonism mouse model could provide novel insights pathomechanism specific increase mtdna deletions age contribute dopaminergic neurodegeneration parkinson disease published elsevier inc
tetralogy fallot tof one common forms cyanotic congenital heart disease usually managed serial surgical repairs repaired prosthetic valve conduit susceptible life threatening infection fdg pet effective alternative evaluate source infection examinations inconclusive report unusual case infected pulmonary artery conduit tof repair although echocardiogram negative vegetation later confirmed surgery pathology case highlights role fdg pet problem solving tool potential endocarditis cardiac device infection cases complex cardiac surgery
eye tracking extensively used quantify audience preferences context marketing advertising research primarily methodologies involving static images stimuli advertising shelf testing website usability however methodologies generalize narrative based video stimuli specific storyline meant communicated audience paper novel metric based eye gaze dispersion within across viewings quantifies impact narrative based video stimuli preferences large audiences presented metric validated predicting performance video advertisements aired super bowl final particular metric shown explain variance likeability scores super bowl ads measured usa today meter addition comparing proposed metric heart rate variability hrv indices associated metric biological processes relating attention allocation underlying idea behind proposed metric suggests shift perspective comes evaluating narrative based video stimuli particular suggests audience preferences video modulated level viewers lack attention allocation proposed metric calculated narrative based video stimuli movie narrative content emotional content etc thus potential facilitate use stimuli several contexts prediction audience preferences movies quantitative assessment entertainment pieces prediction impact movie trailers identification group individual differences study attention deficit disorders study desensitization media violence
background early life exposure household pets capacity reduce risk overweight allergic disease especially following caesarean delivery since evidence pets also alter gut microbial composition infants changes gut microbiome putative pathways pet exposure reduce risks health investigate impact pre postnatal pet exposure infant gut microbiota following various birth scenarios study employed large subsample infants canadian healthy infant longitudinal development study child cohort whose mothers enrolled pregnancy participating mothers asked report household pet ownership recruitment second third trimester months postpartum infant gut microbiota profiled rrna sequencing faecal samples collected mean age months two categories pet exposure pregnancy pre postnatally compared pet exposure different birth scenarios results half studied infants exposed least one furry pet prenatal postnatal periods exposed pregnancy alone exposure time periods common effect birth scenarios pre postnatal pet exposure enriched abundance oscillospira ruminococcus twofold greater likelihood high abundance among vaginally born infants maternal intrapartum antibiotic prophylaxis exposure streptococcaceae substantially significantly reduced pet exposure fdrp reflecting decreased likelihood high abundance pet exposure pregnancy alone reduced likelihood exposure pre postnatal time periods associations independent maternal asthma allergy status siblingship breastfeeding exclusivity home characteristics conclusions impact pet ownership varies different birth scenarios however common exposure pets increased abundance two bacteria ruminococcus oscillospira negatively associated childhood atopy obesity
woven fabric flexible object specify parameters applying inflexible ordinary methods image processing ever considerable errors regards proposing adaptable method fabric image properties concentrated detect yarns position research flexible algorithm proposed containing two stages first inexact ranges fabric parameters determined preprocessing colored fabric images using wavelet transform clustering methods hybrid genetic imperialist competitive algorithm applied optimize obtained ranges detect yarns position achieve better results parameters hybrid ica calibrated using taguchi method results indicate new method error value detecting structural fabric parameters considerably decreased compared common gray scale projection method proposed method capable detecting exact yarns position colored fabric images uneven color intensity low density weave mean precision value fabric images high density weaves mean precision value
background ability recognize respond appropriately threat critical survival neural substrates subserving attention threat may probed using depictions media violence whether neural responses potential threat differ syndrome known methods performed functional mri scans adolescent adult syndrome typically developing individuals group matched age gender min passive cartoon viewing brain activation auditory visual features violence presence protagonist antagonist compared across cartoon segments fmri signal brain dorsal attention network compared thematic violent events within cartoons syndrome control samples results found typical development brain dorsal attention network active violent scenes cartoons significantly specifically reduced syndrome antagonist screen significantly less activation left medial temporal lobe individuals syndrome scenes represented greater relative threat disparity attentional brain activation syndrome control individuals increased reduction temporal autocorrelation dorsal attention network consistent shortened attention span syndrome individuals syndrome exhibited significantly reduced activation primary sensory cortices perceptual impairments may constrain ability respond complex social cues violence conclusions findings may indicate relative deficit emotive perception violence syndrome possibly mediated impaired sensory perception hypoactivation medial temporal structures response threats relative preservation activity pro social brain regions findings indicate specific genetic differences associated syndrome modulate brain response violence complex emotive ideas
article reviews recent advances developments field wearable sensors emphasis subclass devices able perform highly sensitive electrochemical analysis recent insights novel fabrication methodologies electrochemical techniques resulted demonstration chemical sensors able augment conventional physical measurements heart rate eeg ecg etc thereby providing added dimensions rich analytical information wearer timely manner wearable electrochemical sensors integrated onto textile materials directly epidermis various monitoring applications owing unique ability process chemical analytes non invasive non obtrusive fashion manner multi analyte detection easily performed real time order ascertain overall physiological health wearer identify potential offenders environment profound importance development understanding impact mechanical strain textile epidermal tattoo based sensors failure mechanisms well compatibility substrate employed fabrication process conclude review retrospective outlook field identify potential implications new sensing paradigm healthcare fitness security environmental monitoring domains continued innovation detailed attention core challenges expected wearable electrochemical sensors play pivotal role emergent body sensor networks arena
present paper shows innovative multirotor unmanned aerial vehicle uav able easily quickly change configuration order satisfy feature principal structure made universal plate combined circular ring create rail guide able host arms variable number legs arms adjustable contain avionic motor drivers connect main structure electric motor unique arm design defined one allows classical single rotor configurations double rotor configurations amphibious configurations including inflatable elements positioned bottom arms proposed multi rotor system inexpensive universal pieces needed compose platform allows creation kit modular kit allows modular drone different configurations configurations distinguished among number arms number legs number rotors motors landing capability another innovation feature introduction printing technology produce structural elements manner pieces designed produced via fused deposition modelling fdm technology using desktop printers therefore universal dynamic economic multi rotor uav developed
context global software development gsd presents significant challenges share understand knowledge required developing software organizations expected implement appropriate practices address knowledge sharing challenges gsd growing literature gsd widespread adoption important build body knowledge support future research effective knowledge sharing practices objective aimed systematically identifying synthesizing knowledge sharing challenges practices also intended classify recurrent challenges frequently reported practices different contextual settings method used systematic literature review slr reviewing primary studies selected searching gsd literature published last years september applied thematic analysis method analysing data extracted reviewed primary studies results findings revealed knowledge sharing challenges practices gsd could classified main themes management team structure work processes practices team cognition social attributes technology regard contextual settings found empirical studies mainly conducted offshore outsourcing collaboration model distributed two sites studied organizations large enterprises many studies report information several contextual attributes made difficult analyse reported challenges practices respect respective contexts conclusion conclude higher tendency among researchers report practices challenges knowledge sharing gsd given analysis reported knowledge sharing challenges practices fall theme work practices technology related knowledge sharing challenges least reported discussed available technologies supporting knowledge sharing needs gsd organizational contextual information missing large number studies hence possible investigate potential relations knowledge sharing challenges practices contextual attributes gsd teams assert need exploring knowledge sharing context small medium sized organizations avoid risk findings biased specific empirical setting large enterprises distributed india elsevier ltd rights reserved
continuous auxiliary inputs leakage strong side channel attacks article first propose continuous auxiliary inputs leakage model hierarchical attribute based encryption scheme security model adversary ability gain partial updated master keys updated secret keys continually certain leakage attacks moreover resilient leakage hierarchical attribute based encryption scheme constructed security proof scheme provided standard model furthermore give performance comparison scheme relevant scheme john wiley sons ltd
photocatalytic reduction carbon dioxide one pathways involved carbon dioxide conversion process receiving significant attention scientific community last four decades nevertheless mechanism carbon dioxide reduction still unclear information available sufficient developing large scale applications possibly invariable hurdles associated reduction process reductive photocatalytic conversion involves redox reactions occurring interface semiconductor water splitting hydrogen evolution oxygen evolution photo oxidation reactions reactions radical intermediates overall product yield highly dependent extent competing reactions herein discuss perceptions current status interface reactions involvement fundamental mechanistic aspects photocatalytic conversion
article provides much needed commercial perspective gradual growth consumption birth control appliances england wales drawing underutilized parliamentary sources hitherto neglected business records manufacturers vendors distributors new approach reveals consumption patterns varied terms class gender geographical location scholars generally recognized particular analysis production promotion distribution birth control appliances alongside medical goods intended domestic use period demonstrates importance consumption amongand beyond primary married couple household article aims provide medical historian new analytic tool investigating neglected potentially important sites medical decision making
introduction borderline personality disorder bpd common severe mental illness early detection important reliable screening instruments required date however evidence specific bpd screening tool validated spanish speaking population mclean screening instrument borderline personality disorder msi bpd item self report questionnaire detect presence bpd reliable quick manner aim present study validation msi bpd use spanish speaking population method psychometric properties msi bpd spanish version examined sample participants outpatients possible diagnosis bpd healthy controls results exploratory factor analysis revealed existence factorial structure scale showed high internal consistency optimal test retest reliability icc using logistic regression analyses taking dib reference best cut determined obtaining good sensitivity specificity area curve discriminant analysis showed classification ability conclusions spanish version msi bpd good psychometric properties measure screening bpd ease quickness use make valuable detect presence bpd clinical research settings sep sepb published elsevier espana rights reserved
cognitive reserve shows protective effects alzheimer disease reduces risk dementia despite clinical significance clinically useful diagnostic biomarker brain changes underlying available yet aim develop fully automated approach applied fmri produce biomarker associated subjects increased risk computed resting state global functional connectivity gfc average connectivity strength voxel within cognitive control network may sustain due central role higher cognitive function training sample including mild cognitive impairment mci subjects healthy controls found mci subjects high median years education showed increased frequency high gfc values compared mci summary index capturing surplus frequency high gfc computed called gfc reserve gfc index gfc discriminated mci mci area roc cross validation independently recruited test sample mci subjects showed higher levels gfc index predicted higher years education alternative questionnaire based proxy controlled memory performance gray matter cognitive control network white matter hyperintensities age gender conclusion gfc index captures gfc changes within cognitive control network provides biomarker candidate functional brain changes patients increased risk
purpose microrna mir emerged therapeutic target treatment breast cancer study designed compare responses breast cancer cells non transformed breast epithelial cells combined regimen mir inhibition radiation materials methods mda breast cancer mcf non transformed mammary epithelial cell lines used comparison vitro study stable knockdown mir performed using lentiviral approach response cells monitored irradiation using sham irradiated cells controls response cells established performing various functional assays cell viability cell attachment clonogenic survival cell cycle analysis microtissue formation results knockdown mir induced significant increase apoptosis growth delay mda cancer cells compared non transformed mcf cells combined radiation anti mir treatment mda cells show reduced cell growth viability presented inability form colonies mcf cells sensitive combined treatment also confirmed colony forming assay conclusions cellular response combined treatment anti mir radiation different cancer non cancer cells highly support idea linking mir inhibitor radiation treatment future therapeutic approaches breast cancer
wireless communication widely used node localization various automation domains schemes based time difference arrival tdoa good compromise achievable accuracy implementation effort due restrictions possible reference sensor positions industrial environments geometric conditions reference mobile nodes locations often difficult consequently iterative algorithms fail result high computational effort exact direct methods introduce additional errors result valid pair solutions existing direct methods thus either rely priori information sort one two solutions revert nonexact linearization approaches underlying hyperbolic equations work present direct approach applies exact direct methods resolves ambiguous pairs solutions without priori information divide conquer structure high computational efficiency available exact direct methods makes good candidate fast parallel computing distributed sensor networks performance compared cramer rao lower bound iterative gaussnewton method another direct method new method presented tdoa scheme also applied time arrival range based scheme
paper discusses implementation deformable ring gears multi body simulation models mbs models planetary gearboxes using example wind turbine purpose add mbs software simpack developed tested project partners bosch rexroth institute machine elements machine design rwth aachen university ime presented research includes measurement campaign test rig owned bosch rexroth obtain data validation newly developed add
objectives purpose examine relation social risk factors cumulative burden social risk factors parent reported dental health dental care seeking behavior methods national survey children health data analyzed children title block grant regions multivariate logistic regressions estimated ten social risk factors well cumulative risk index find associations poor condition teeth presence dental caries dental care visits results almost risk factors significantly associated poor condition teeth presence dental caries models associating dental care visits suggested low family income poor maternal mental health high school education less multi racial race significant factors regional variation existed risk factors association outcomes income education poor maternal mental health consistently played significant role adverse outcomes cumulative risk index strongly related poor oral health outcomes weaker relationship dental care utilization conclusions practice children experiencing certain social risk factors low family income high school education less poor maternal mental health likely greater risk poor dental health low levels dental care seeking behavior children experiencing multiple social risks greater risk poor oral outcomes children experience fewer social risks approach involves social determinants health needed address issues
complex software development projects consistent planning communication stake holders crucial effective collaboration across different stages software construction taking view software development maintenance part broader phenomenon software evolution paper argues adoption knowledge management practices software engineering would improve software construction particularly software maintenance research work presents guidance model areas knowledge management software engineering combining insights across corporate software projects means evaluating effects people organization technology workflows processes elsevier ltd rights reserved
context processes central operation many systems organizations process centric systems ranging enterprise workfow systems open distributed service compositions significantly increased number complexity objective designers process centric systems benefit process abstractions including patterns capturing allowing reuse designs frequent operational problems existing process patterns detection techniques efficiency problems difficulties identify partial inexact pattern instances method propose process pattern detection technique based family subgraph matching algorithms algorithms implement surjective graph morphism detection mechanism incorporate semantic similarity computation types attributes process graph elements results efficiency addressed using simplified data structures reducing search space exploration match accuracy time complexity demonstrated experimental study conclusions using process patterns allows business technical processes provided sharable service resources patterns help manage processes configurable resources pattern define family concrete customizable processes
background hyperactive secretion pathogenic effects interleukin iga detected different arthropathies recent evidence revealed cytokines regulate mucosal iga secretion however unknown whether mediates synovial iga production aim investigate connection synovial iga production joint study included synovial fluids patients rheumatoid arthritis spondyloarthritis spa osteoarthritis levels transforming growth factor tgf beta cell activating factor tnf family baff anti lipopolyssacharide lps immunoglobulin investigated enzyme linked immunosorbent assay elisa total iga measured radial immunodiffusion assay synovial fluid derived mononuclear cells sfmc stimulated bacterial antigens conditioned media cytokines iga analyzed supernatants results tgf beta increased spa compared patients concentration correlated disease activity score das anti lps iga levels bacterial stimulated sfmcs spa patients secreted higher vehicle stimulated sfmcs conditioned media containing induced anti lps iga production sfmcs independent activity concentrations synovial tgf beta baff correlated anti lps total iga levels respectively blockade decreased production tgf beta anti lps iga stimulated sfmcs conclusions study reports connection iga secretion joint addition demonstrates enterobacterial antigens trigger synovial production tgf beta baff may mediate effect iga production circuit may contribute pathogenesis inflammatory joint diseases
study introduces efficient procedure estimate structural response suspension bridge real time based limited set measured data unlike conventional techniques proposed procedure employ mode shapes frequencies study proposed technique used estimate response suspension bridge structure based set strain gauge measurements finite element analysis performed set structural parameters namely computed flexibility matrix computed hanger forces matrix response bridge estimated without additional finite element analysis using computed structural parameters measured hanger strains alfred zampa memorial bridge interstate california selected study high fidelity finite element model bridge developed using general purpose computer program adina proposed method proven capability estimate type structural response real time based measured hanger strains provides important part integrated structure health monitoring shm system major bridges
significant proportion patients type diabetes mellitus low testosterone level relative reference ranges based healthy young men small number patients suffer classical hypogonadism result recognizable hypothalamic pituitary gonadal axis pathology cut value serum testosterone level men without obvious hypothalamic pituitary gonadal axis pathology controversial unclear extent low serum testosterone level causally leads type diabetes metabolic syndrome theoretical standpoint complex interactions among hypothalamic pituitary gonadal axis body composition insulin resistance influenced intrinsic extrinsic factors give rise metabolic syndrome glucose intolerance low grade inflammation increase risk cardiovascular disease although low serum testosterone level frequently coexists cardiometabolic risk factors might serve biomarker studies required clarify causal mediating modifying roles low serum testosterone level development adverse clinical outcomes currently insufficient randomized clinical trial data evaluate effects testosterone replacement therapy meaningful clinical outcomes risk benefit ratio testosterone therapy high risk subjects type diabetes also requires elucidation present article aims review current evidence low serum testosterone levels patients type diabetes implications cardiovascular risk factors metabolic syndrome adverse clinical outcomes
aims surveillance geographical variations cardiovascular health important order achieve objectives reducing regional health disparities aimed explore differences cardiovascular disease cvd mortality prevalence cvd diagnoses made primary patient care well risk factor distribution geographic regions urban rural iceland methods nationwide health registers obtained data cvd mortalities primary healthcare cvd contacts hospital cvd discharges well data cvd risk factors national health survey response rate age standardised annual mortality primary healthcare contact hospital discharge rates due cvd calculated per population inside urban outside rural capital area logistic regression used explore regional differences cvd risk factors results observed slightly higher total cvd mortality rates among women outside compared inside standardised rate ratio srr confidence interval particularly due atrial fibrillation srr heart failure srr ischemic heart disease srr reduced mortality risk cerebrovascular disease srr rates hospital discharges primary care contacts diseases well prevalence several modifiable risk factors generally higher outside particularly among women conclusions higher prevalence modifiable risk factors cvd rural areas especially among women calls refined treatment health promoting efforts rural areas
year old boy presented month history high grade fever night sweats without chills rigors examination moderate hepatosplenomegaly multiple enlarged cervical axillary lymph nodes hemogram revealed anemia marked eosinophilia initial investigations negative except anti hcv igg antibodies positive bone marrow aspirate showed single histiocyte containing suspicious intracellular yeast like forms cervical lymph node aspiration revealed heavy load intra extracellular histoplasma spp disseminated histoplasmosis remains unusual cause peripheral eosinophilia diagnosis often rendered fairly easily cytomorphological evaluation case illustrates indian pathologists must maintain high index suspicion unexpected infectious disorders cases eosinophilia
bertholletia excelsa tree produces brazil nuts vast economic importance amazon region export commodity aim study assess presence aspergillus section nigri brazil nut samples different stages production chain verify toxigenic potential fumonisin production isolates along presence mycotoxin brazil nut samples fungal infection ranged different stages harvest processing chain water activity nuts total section nigri strains isolated brazil nuts strains tested ability produce strains producers concentrations ranging strains showed traces less detection limit producers although several samples showed high contamination section nigri sample contaminated
background objective study validate turkish version quick mild cognitive impairment qmci screen methods total patients aged years referred geriatric outpatient clinic memory loss included qmci compared turkish versions standardized mini mental state examination montreal cognitive assessment moca results qmci higher accuracy moca discriminating subjective memory complaints smcs cognitive impairment mild cognitive impairment mci dementia borderline significance adjusting age education qmci also higher accuracy moca differentiating mci smc became nonsignificant adjustment similar pattern shown distinguishing mci dementia test reliability qmci strong conclusion qmci reliable useful screening tool discriminating mci smc dementia turkish population
mucous flow tracheal lumen generated beat motion ciliated cells provide clearance function discharging harmful dust particles viruses due physiological importance cilia generated flow rheological properties mucus investigated intensively effects viscosity cilia generated flow however fully clarified study measured bulk background velocity ciliary flow using micro particle tracking velocimetry method various viscosity conditions mice results showed flow velocity decreased increase viscosity ambient fluid moreover previous study clarified pump power generated cilia provides important information regard understanding molecular motor properties cilia measurements ciliary flow ciliary motion conducted determine cilia pump power results indicated cilia pump effective stroke drive ciliary flow efficiently high viscosity conditions findings necessary resolve clearance function
seismic images composed positive negative seismic wave traces different amplitudes robein seismic imaging review techniques principles merits limitations houten eage association amplitudes together color palette forms complex visual patterns color intensity patterns directly related impedance contrasts higher contrast higher color intensity generally speaking low impedance contrasts depicted low tone colors creating zones different patterns whose features evident automated mapping option available commercial software work workflow semi automatic mapping seismic images focused areas low intensity colored zones may associated geobodies petroleum interest proposed cie color space used perform seismic image processing helped find small significant differences pixel tones process generated binary masks bound color regions low intensity colors three dimensionalmask projection allowed construction structures zones geobodies proposed method applied set digital images seismic cube tested four representative study cases obtained results encouraging interesting geobodies obtained minimum information
local area wireless networking technology widely used different purposes data transmission wireless communication connection often result faster reliable internet access cheap penetration test proactive authorized attempt evaluate security infrastructure safely attempting exploit system vulnerabilities including service application flaws improper configurations even risky end user behavior several operating system distributions like kali linux pentoo taken penetration testing systems require highly skilled technical users approach convert complete automated tool eliminates manual effort provides complete solution assessing security proposed automated tool implemented mobile application would provide handy analysis penetration suite mobile application aims complete advanced toolkit security experts perform network security assessments mobile device issues challenges related proposed mobile app discussed paper
healthy sleep essential human well sleep analysis necessary process majority sleep disorders diagnosis work propose analyze brain activity electroencephalogram analysis order identify sleep stages variation focus classification phase works sleep stages classification based prior experts signal scoring hard task many available unlabeled data remain unused explore data enrich study sleep classification propose hybrid approach based learning classifier systems artificial neural networks effectiveness proposed approach investigated using real eelectroencephalography data good results reached comparing supervised learning methods usually used proposed approach provides also explicit model could analyzed posteriori experts
presence defects modifies stiffness strength materials also changes morphologies latter effect extremely significant low dimensional materials graphene show work graphene swells point defects mono vacancies created finite concentrations distorted geometry resulted areal expansion combination plane softening effect predicts unusual defect concentration dependence stiffness measured supported graphene membrane nanoindentation tests leads defect induced stiffening phenomenon mechanism elucidated analytical membrane model well numerical simulations atomistic continuum levels addition elucidate counter intuitive observations experiments computer simulations findings also highlight role defect modulated morphology engineering applied design nanoscale material structural applications elsevier ltd rights reserved
exact expression effective resistance two vertices cycle graph four nearest neighbors given turns expression written terms effective resistance cycle graph square fibonacci numbers bisected fibonacci numbers consequence closed form formulas total effective resistance first passage time mean first passage time simple random walk cycle graph four nearest neighbors obtained finally closed form formula effective resistance first neighbors removed obtained
early detection alzheimer disease imperative enabling understanding clinical treatment disorder well preventing progression imaging agents specifically targeting beta plaques brain retina may lead early diagnosis among near infrared fluorescent nirf imaging emerged attractive tool noninvasively identify monitor diseases preclinical early stages present study report design synthesis evaluation series new near infrared fluorescent probes probes displayed maximum emission pbs falls goad range nirf probes among showed highest affinity toward beta aggregates excellent targeting ability beta plaques slices brain retina tissue double transgenic mice compounds also found effectively prevent beta fibril formation disaggregate preformed beta fibrils showing promising potential theranostic agents diagnosis therapy
integrating functionality smaller form factor higher performance lower power consumption pushing semiconductor technology scaling limits chip stacking touted silver bullet technology keep moore momentum fuel next wave consumer electronic products additionally complexity digital designs imposes computer aided design algorithms getting harder slower paper introduces framework application implementation onto reconfigurable architectures contrast existing approaches proposed solution customizable according constraints posed application target device order improve performance metrics experimental results highlight effectiveness framework achieve average enhancements terms maximum operation frequency power consumption respectively compared state art algorithms
multi scale computer aided design manufacturing processes magnesium bracket automotive industry main goal present paper tensile tests various deformation conditions temperatures strain rates etc performed obtain flow stress data necessary macro scale finite element analysis digital material representation concept used create micro scale model evaluate influence local microstructural features form twins material behaviour algorithm based cellular automata method capable replicating microstructural morphology twins proposed provide digital material representation model bracket made magnesium alloy formed elevated temperature degrees description study well results obtained two length scales presented paper
introduction chromosomal rearrangements involving gene ros define distinct molecular subset nsclcs sensitivity ros inhibitors recent reports suggested significant overlap ros fusions oncogenic driver alterations including mutations egfr kras methods identified patients institution ros rearranged nsclc undergone testing genetic alterations additional oncogenes including egfr kras anaplastic lymphoma receptor tyrosine kinase gene alk clinicopathologic features genetic testing results reviewed also examined separate database ros rearranged nsclcs identified commercial foundationone assay foundation medicine cambridge results among patients ros rearranged nsclc evaluated institution none harbored concurrent alk fusions egfr activating mutations kras mutations detected two cases one harbored concurrent noncanonical kras mutation unknown biological significance separate ros fluorescence situ hybridization positive case targeted sequencing failed confirm ros fusion instead identified kras mutation concurrent mutations raf proto oncogene serine threonine kinase gene braf erb receptor tyrosine kinase gene erbb phosphatidylinositol bisphosphate kinase catalytic subunit alpha gene pikca akt serine threonine kinase gene akt mitogen activated protein kinase kinase gene mapk detected analysis independent data set ros rearranged nsclcs identified foundationone demonstrated rare cases occurring driver mutations egfr one kras three cases occurring ros alk rearrangements conclusions ros rearrangements rarely overlap alterations egfr kras alk targetable oncogenes nsclc international association study lung cancer published elsevier inc rights reserved
tuning controllers field intrinsic research control automation industry proportional integral derivative pid controllers variant forms much studied automatic controller tuning owing simplicity performance challenge autotuning controllers increased systems involve delay use metaheuristics soft computing methods increasingly dominant autotuning pid controllers paper deals design pid controller smith predictor processes delay algorithm employs stud genetic algorithm search intensified using derivative free search methods namely simplex derivative pattern search implicit filtering resulting algorithms named dfsgstudga dfsgstudga respectively effectiveness discussed schemes compared existing methods controller tuning robustness terms vector gain margin vgm tolerance plant uncertainty
construction process project group full uncertain factors large numbers resources required easy lack certain resources based programming theory project group resource reallocation optimization model established supplied resource quantities insufficient applying programming theory linear programming model including labor material resource reallocation established regards shortest delaying construction period minimum extra increased cost objective function guarantees rational reallocation resources actual example analysis optimize configuration actual project group situation insufficient resources supply occurs vadilated
ontologies becoming popular knowledge representation methods particularly areas semantic web smart environments paper focuses design user behaviour ontologies ambient intelligence ami environment using ontology creation tool sensors installed environment users behaviour sensed stored devices environment stored behaviour data refined formed temporal sequence ontology constructed mapping relations behaviour related temporal sequence work demonstrated different ways ontological representations advantage approach makes cognitive support easier teachers
purpose propose treatment strategy simultaneously discovered non small cell lung cancer nsclc cardiovascular disease cvd methods patients underwent surgery nsclc cvd requiring invasive treatment simultaneously discovered details treatments well short long term outcomes pulmonary resection analyzed results cvd included coronary artery disease patients valvular disease abdominal aortic aneurysm congenital heart disease twenty six patients underwent two stage treatment seven received simultaneous surgery patients whose treatment cvd preceded lung cancer median interval treatments days range days postoperative complications occurred patients underwent stage treatment underwent simultaneous surgery notably patients underwent lobectomy bilobectomy experienced respiratory dysfunction required intubation year overall survival rate patients conclusion outcomes two stage treatment present cohort favorable given experience simultaneous surgery lung cancer cvd therefore selected patients may benefit strategy
pdea camp cgmp phosphodiesterase important signal transduction within medium spiny neurons human striatum gene region associated bipolar disorder via case control linkage studies three studied human pdea isoforms differ termini trafficking within cell pdea found predominantly plasma membrane pdea pdea remaining primarily within cytosol rna sequencing rlm race studies human putamen caudate nucleus revealed new exons novel transcripts pdea predicted produce proteins unique termini novel first exons transcripts highly conserved non human primate species rarely found mammals one hundred eight previously classified intronic snps found within novel pdea exons classified rare variants since rare variants localize utr regions may influence pdea transcription translation mrna stability dysregulation camp signaling proposed cause bipolar disorder pdea inhibitors investigated potential therapeutics schizophrenia understanding mechanisms contributing pdea expression human striatum may provide evidence linking gene phenotypes observed neuropsychiatric disorders elsevier rights reserved
paper considers realization quasi sliding mode control boost type converter atmega microcontroller proposed control law represents combination discretetime sliding mode generalized minimum variance control techniques control design based input output converter model sensed output voltage used generating control signal approach simplifes practical realization boost converter since need current sensors introducing additional discrete time integrator control converter accuracy steady state load input voltage variations enhanced experimental prototype developed several experiments conducted validate functionalities proposed solution maximum load line regulation errors proposed converter respectively
ever increasing nonlinear loads supplies changing dynamics electrical network levels harmonics rise polluting electrical network posing new challenges designers operators maintain present power quality levels improve performance electrical network many control schemes devices like active power filter proposed still improvement required paper proposes five level diode clamped multilevel inverter based distribution statcom mli dstatcom synchronous reference frame based control harmonic mitigation three phase four wire system nonlinear balanced unbalanced load designed simulated matlab simulink performance analysis proposed mli dstatcom results provide evidence restricting harmonic currents load end prevent entering source effectively performance five level three level two level dstatcom compared nonlinear balanced unbalanced load simulation result analysis show superior performance five level diode clamped mli dstatcom controlled using srf
parents children attention deficit hyperactivity disorder adhd oppositional defiant disorder odd often elevated adhd depressive symptoms increase risk ineffective parenting interparental discord however little known whether child adhd odd behavior parent adhd depressive symptoms uniquely synergistically predict quality parenting interparental communication triadic mother father child interactions ninety parent couples including children diagnosed adhd randomly assigned interact year old confederate child male exhibiting either adhd odd like behavior typical behavior parents reported adhd depressive symptoms parents observers rated quality parenting interparental communication interaction actor partner interdependence modeling indicated child adhd odd behavior predicted less positive negative parenting communication independent adult adhd depressive symptoms parent couples including two parents elevated adhd communicated positively managing children exhibiting adhd odd behavior couples managing children behaving typically couples one parent elevated adhd symptoms couples including one parent one parent without elevated adhd depressive symptoms parented less positively negatively communicated negatively managing children exhibiting adhd odd behavior managing children behaving typically taken together depending similarity adhd depressive symptom levels parent couples adults managing children exhibiting adhd odd behavior may parent communicate positively negatively findings highlight need consider psychopathology parents treating children adhd two parent homes
dacomitiniban irreversible pan erbb tyrosine kinase inhibitor tki causes diarrhoea patients dacomitinib induced diarrhoea previously investigated mechanisms remain poorly understood present study aimed develop vitro vivo model dacomitinib induced diarrhoea investigate underlying mechanisms cells treated dacomitinib resistance viability measured using transepithelial electrical resistance teer xtt assays rats treated dacomitinib daily via oral gavage days group weights diarrhoea incidence recorded daily rats administered fitc dextran cull serum levels fitc dextran measured serum biochemistry analysis conducted detailed histopathological analysis conducted throughout gastrointestinal tract gastrointestinal expression erbb erbb erbb analysed using pcr ileum colon analysed using multiplex expression various cytokines cells treated dacomitinib showed alteration teer cell viability rats treated dacomitinib developed severe diarrhoea significantly lower weight gain dacomitinib treatment led severe histopathological injury localised ileum damage coincided increased levels mcp ileum preferential expression erbb region compared regions study showed dacomitinib induces severe ileal damage accompanied increased mcp expression gastrointestinal permeability rats histological changes pronounced ileum also region highest relative expression erbb new dacomitinib hunt kill tumor cells resist chemotherapy drugs receptor family dacomitinib seizes tumor cellsthe erbb familyalso adorn healthy gastrointestinal epithelial cells causing patients suffer dacomitinib induced diarrhea authors sought understand mechanism behind hopes managing rats observed dacomitinib caused severe injury ileum region highest erbb expression gastrointestinal permeability inflammation monocyte infiltration also seems likely contribute damage since observed increased mcp ileum
recent mobile robot researchers focus obstacle avoidance path tracking unknown environment paper presents new algorithm using straight line equation adaptation mechanism makes robotino reaching destination accurately also enable detect avoid static dynamic obstacles using nine infrared sensors brief robotino dynamic description discussed help understanding proposed control algorithm detailed algorithm design procedure evaluated simulation results showed effectiveness proposed algorithm sense avoiding obstacles without collision robotino predefined path
multi proxy signature variant proxy signature allows delegator original signer may delegate signing rights many proxy signers comparing proxy signatures multi proxy signatures effectively prevent proxy signers abuse signing rights also rapid development identity based cryptography identity based multi proxy signature ibmps schemes proposed comparing proxy signature based public key cryptography ibmps simplify key management used applications presently many identity based multi proxy signature schemes proposed constructed random oracle model also existing security model identity based multi proxy signature enough complete according boldyreva work paper present framework ibmps users number proxy signers participating signing show detailed security model ibmps framework present identity based multi proxy signature scheme standard model comparing identity based multi proxy signature schemes proposed scheme complete security
background food addiction model receiving increasing interest scientific community available empirical evidence suggests condition may play important role development course physical mental health conditions obesity eating disorders addictive behaviors however epidemiological data exist comorbidity gambling disorder phenotype occurrence objectives determine frequency comorbid condition assess whether comorbidity features unique clinical profile compared without generate predictive models presence sample method data correspond treatment seeking patients met criteria hospital unit specialized behavioral addictions results point prevalence diagnosis higher ratio found women compared men lower prevalence associated older age patients high scores characterized worse psychological state risk diagnosis increased patients high scores personality traits harm avoidance self transcendence low scores cooperativeness conclusion occurrence treatment seeking patients related poorer emotional psychological states treatment interventions related behavioral addictions consider potential associations problematic eating behavior aim include techniques aid patients better managing behavior
malignant tumors head neck carcinomas sixth common type cancer current systemic therapies cancer show side effects normal tissues short term efficacy due drug resistance consequently much interest identifying new drugs cancer treatment crocin active ingredient saffron shown cytotoxic effects cancer cell lines chemo radiotherapy standard treatment head neck cancer present study cytotoxic effects inducing apoptosis radiation sensitivity crocin evaluated head neck cancer cell line cells cultured dmem medium incubated different concentrations crocin exposed gamma rays cell viability quantified mtt assay apoptotic cells determined using staining dna fragmentation flowcytometry sub peak crocin decreased cell viability cells time concentration dependent manner crocin also induced sub peak flowcytometery histogram treated cells compared control suggesting apoptotic cell death caused toxicity crocin also shown sensitize cells radiation induced toxicity apoptosis simultaneous use crocin radiation therefore increases radiation sensitivity cell death thus study crocin considered potential drug sensitizer cancer treatment
incidence trochanteric fractures rising increasing number senior citizens osteoporosis various modalities reduction internal fixation however incidence complications remains high herein article discuss issues influence fixation outcomes unstable trochanteric fractures moreover results prospective randomised cohort time bound hospital based comparative study presented elsevier ltd rights reserved
current study examined cultural factors religious background religious participation parents views prayer parents concepts god contribute children differentiation capabilities human minds god mind protestant christian roman catholic muslim religiously non affiliated parents preschool aged children interviewed children muslim parents differentiated god mind human minds human minds fallible god children greater differentiation god humans minds parents least anthropomorphic conceptions god additionally unique effect raised religiously non affiliated home degree children differentiation god human minds religious context factors accounted words children religious non affiliates differentiated humans god least differentiation unrelated religious context factors findings delineate ways religious context differences influence concepts god earliest formation
recently revolutionary achievements silicon based conventional terahertz thz millimeter wave wave integrated circuits particularly advancement cmos technology however unlike radio frequency integrated circuits rfics innovative designs lack various circuit techniques still remain unknown thz gap paper multi band thz amplifier presented cmos technology adaptive band selection technique smart amplifier able adjust band operation respect input signal power frequency addition circuit performance adjusted achieve maximum power gain order achieve multi band external neutralization self healing technique vastly utilized means tunable transmission lines ttls proposed smart system contains tunable transmission lines stage amplifier core two successive approximation register based analog digital converters sar adcs digital control core two chip power sensing blocks fabricated amplifier achieves dbm sat dbm power gain ghz frequency range proposed amplifier demonstrates highest operation frequency among published state arts cmos technologies
background much attention given relationship various training factors athletic injuries study examined impact sleep deprivation injury rates young athletes information sleep practices gathered part study designed correlate various training practices risk injury adolescent athletes methods informed consent participation online survey training practices review injury records obtained student athletes combined middle high school grades parents online surveys completed adolescent athletes completion rate including male female athletes mean age years range students responses correlated data obtained retrospective review injury records maintained school athletic department results multivariate analysis showed hours sleep per night grade school best independent predictors injury athletes slept average hours additional grade school athletes times likely injury confidence interval conclusion sleep deprivation increasing grade school appear associated injuries adolescent athletic population encouraging young athletes get optimal amounts sleep may help protect athletic injuries level evidence level iii
labyrinth channels widely adopted emitter designs regulate water flow flow regime head loss labyrinth channels significant impacts hydraulic performance emitters study flow behavior water passing emitter channel observed using micro particle image velocimetry piv head loss flow analyzed emitter triangular labyrinth channel results show flow regime consistent classical theory hydraulics governing straight channels even cross sectional area small small critical reynolds number laminar turbulent flows labyrinth channel approximately range local head loss factor decreases reynolds number increases labyrinth channels smaller cross sectional areas mmx mmx local head loss factor related reynolds number function boundary conditions labyrinth channel reynolds number exceeds approximately cross sectional areas mmx mmx ratio local head loss total head loss ftotal first increases remains nearly constant reynolds number increases labyrinth channel head loss labyrinth channel almost equal local head loss ftotal approximately cross sectional areas greater mmx results used optimizing design emitter channels
paper presents new single phase asymmetrical cascaded multilevel link inverter proposed inverter comprises two stages main stage inverter consists multiple similar cells half bridge inverter consisting two switches single source cells connected cascaded manner fixed neutral point source values made equal increase performance inverter second circuit folded cascaded bridge circuit operating line frequency one main advantages proposed topology modular type thus extended high stages without changing configuration main stage circuit two control schemes namely low switching selective harmonic elimination sinusoidal pulse width modulation employed validate proposed topology detailed approach control scheme switching pulses discussed detail prototype proposed system implemented laboratory verify validity proposed topology
main reasons installation power quality meters distribution transformer substations power quality monitoring global evolution electrical network towards smart grid case measurements meters properly synchronised centralised new possibilities control evaluation network enabled contribution proposes possibility earth fault localisation aid synchronised data recorded low voltage side medium voltage low voltage transformers compensated neutral distribution networks equipped auxiliary resistor short time increasing active part fault current described method uses voltage sags evoked connecting auxiliary resistor locating faulty section proposed method tested help numerical model presents part distribution network
recombinant basic fibroblast growth factor bfgf potent mitogen mesenchymal cells accelerates bone union repair applied locally defect sites however bfgf diffuses rapidly bone defect sites repeated dosing required sustained therapeutic effect previously fused collagen binding domain cbd polycystic kidney disease pkd domain clostridium histolyticum class collagenase colh bfgf demonstrated fusion protein markedly enhances bone formation loaded onto collagen materials used grafting however systemic injection fusion protein consisting parathyroid hormone pth cbd shown accelerate bone formation osteoporosis model rapidly treatment pth pkd cbd fusion protein compared biological properties two collagen binding forms bfgf bfgf cbd bfgf pkd cbd fusion proteins promoted vitro proliferation periosteal mesenchymal cells indicating biological activity similar native bfgf vivo periosteal bone formation assays rat femurs showed bfgf cbd bfgf pkd cbd induced periosteal bone formation higher rates collagen sheet alone bfgf however bfgf pkd cbd markedly enhanced bone formation higher collagen binding ability bfgf cbd vitro protein release assays taken together results suggest pkd domain increases retention bfgf graft sites enhancing collagen binding affinity therefore bfgf pkd cbd collagen composite appears promising material bone repair clinical setting copyright john wiley sons ltd
continuous technical progress smartphone built modules embedded sensing techniques created chances context aware automation decision support home environments studies area mainly focus feasibility demonstrations emerging techniques system architecture design applicable different use cases lacks service customization strategies tailoring computing service proactively satisfy users expectations investigation aims chart challenges take advantage dynamic varying context information provide solutions customize computing service contextual situations work presents rule based service customization strategy employs semantic distance based rule matching method context aware service decision making rough set theory based rule generation method supervise service customization simulation study reveals trend algorithms time complexity number rules context items prototype smart home system implemented based smartphones commercially available low cost sensors embedded electronics results demonstrate feasibility proposed strategy handling heterogeneous context decision making dealing history context discover underlying rules shows great potential employing proposed strategy context aware automation decision support smart home applications
paper reviews quantitative qualitative brazilian research published opinions knowledge attitudes health professionals abortion included publications samples composed professionals degree training papers categorized according methodological characteristics data approach technique instrument data collection professional categories research site sample size sampling technique next categorized main themes research genetic counseling emergency contraception finally categorized results research technical legal knowledge moral perspectives opinions law opinions national health system hypothetical concrete attitudes publications identified suggested broad approval abortion cases currently allowed law high rejection criminalization cases serious fetal malformations articles reported investigated medical professionals obstetricians gynecologists nurses little data social workers psychologists identified instruments providing minimum data validity reliability analysis cross cultural adaptation believe future development instruments qualities could facilitate implementation new research topic including greater coverage diversification professional categories studied
although many aspects ovarian differentiation established comparatively little known prenatal follicle formation differentiation bovine ovaries objective investigation study role surface epithelium development germ cell nests germ cell cords follicle formation fetal bovine ovary associated important proliferation apoptotic features investigated additionally expression pattern protein detected strong increase mitotic figures detected surface epithelium germ cell nests germ cell cords ovaries crown rump length crl oocytes positively stained bovine ovaries fetuses crl staining intensity enhanced parallel increasing oocyte follicle sizes ovary development later stages strong staining observed healthy oocytes contradistinction atretic oocytes expression protein could found conclusion increasing mitosis index surface epithelium cells well oogonia directly beneath surface epithelium combination open surface connection stages crl bovine fetal ovaries could play important role period time ongoing folliculogenesis derivation granulosa cells additionally positive oocytes primordial later follicle stages joined high rate positive index surrounding granulosa cells indicate oocytes protein perhaps useful marker intact oocytes bovine ovaries copyright karger basel
report two experiments supporting theory children understanding ownership rights related notions body rights experiment investigated year olds developing sensitivity physical contact judgments acceptability behaving relation owned objects body parts experiment used simpler design investigate year olds findings confirmed two predictions theory first experiments children judgments ownership body rights similarly affected physical contact second judgments kinds rights yoked development age related changes judgments ownership rights paralleled changes judgments body rights findings additional import theories ownership rights suggest physical contact may crucial factor whether behaviors targeting property judged permissible elsevier inc rights reserved
aim rhoa rho associated kinase arginase implicated vascular complications diabetes study investigated whether rhoa rho associated kinase arginase inhibition protect myocardial ischaemia reperfusion injury type diabetes mechanisms behind effects methods rats streptozotocin induced type diabetes non diabetic rats subjected min myocardial ischaemia reperfusion randomized treatment saline rhoa rho associated kinase inhibitor hydroxyfasudil nitric oxide synthase inhibitor monomethyl arginine monoacetate followed hydroxyfasudil arginase inhibitor omega hydroxy arginine monomethyl arginine monoacetate followed omega hydroxy arginine monomethyl arginine monoacetate given intravenous ischaemia results myocardial arginase activity arginase expression rhoa rho associated kinase activity increased type diabetes rhoa rho associated kinase inhibition arginase inhibition significantly reduced infarct size diabetic non diabetic rats cardioprotective effects hydroxyfasudil omega hydroxy arginine diabetes abolished nitric oxide synthase inhibition rhoa rho associated kinase inhibition attenuated myocardial arginase activity diabetic rats via nitric oxide synthase dependent mechanism conclusion inhibition either rhoa rho associated kinase arginase protects ischaemia reperfusion injury rats type diabetes via nitric oxide synthase dependent pathway results suggest inhibition rhoa rho associated kinase arginase constitutes potential therapeutic strategy protect diabetic heart ischaemia reperfusion injury
paper dimensional nonlinear evolution equation investigated used describe reacting mixtures shallow water waves hirota method symbolic computation bilinear forms backlund transformation derived different existing literature moreover shock wave solutions obtained based shock wave solutions propagation collision shock waves discussed via asymptotic graphic analysis different planes oblique elastic collisions among two three shock waves arise planes parallel elastic collisions exist plane shock waves maintain original directions amplitudes velocities except small phase shifts collision shock wave higher amplitude travels faster moves across slower
using music therapy approach assess emotional communication parent child interaction new field child protection however musical improvisations music therapy long known analogue affect attunement early non verbal communication parent infant called investigation value music therapy within field family assessment family therapy specifically wanted investigate strengthen assessment parenting competencies apc developed scores examined psychometric properties apc revised version quantitative study including small embedded qualitative component total dyads children parents participated residential center address emotional neglect functioned non clinical comparison children aged dyads underwent two video recorded music therapy assessment sessions video analyses focused autonomy relationship turns parental response types producing scores mutual attunement nonverbal communication skills emotional parental response psychometric analyses apc included interrater reliability test test reliability internal consistency concurrent validity concluded apc reliable valid adds existing observational instruments parent child interaction
idiopathic pulmonary fibrosis ipf chronic lethal interstitial lung disease unknown etiology recent studies indicated heat shock protein hsp contributes pathogenesis ipf regulation epithelial mesenchymal transition emt however expression role hsp fibroblasts pulmonary fibrogenesis investigated date least best knowledge study examined expression hsp fibrotic lung tissue fibroblasts bleomycin blm challenged mice human lung fibroblasts treated transforming growth factor beta tgf beta results revealed expression hsp significantly increased fibrotic lung tissue fibroblasts blm challenged mice vitro tgf beta stimulated hsp expression differentiation human lung fibroblasts knockdown smad expression nuclear factor kappa subunit attenuated tgf beta induced increase hsp expression differentiation human lung fibroblasts addition knockdown hsp expression attenuated tgf beta induced activation erk smad inhibited differentiation human lung fibroblasts whole findings study demonstrate hsp expression upregulated lung fibroblasts pulmonary fibrosis subsequently hsp modulates lung fibroblast differentiation smad erk pathways
diabetes mellitus associated distribution cognitive functioning hyperglycemia induced oxidative stress proposed cause memory complications diabetes including cognitive impairment aim study examine total green tea extract tgte potent free radical scavenger spatial impairment streptozotocin diabetic rats eight weeks diabetes induction tgte administrated throught drinking water learning memory behavior evaluated morris water maze task male rats estimation oxidative stress parameters lipid peroxidation lpo total antioxidant capacity frap total thiol groups blood measured total green tea extract showed improved cognitive impairment diabetic groups changes significant also significant increase frap level total thiol groups treated green tea groups control group study demonstrated effectiveness tgte spatial impairment oxidative stress induced diabetes mellitus
effective initial sampling plays important role capturing key details energy surfaces multi component multi sublattice phases purposes accurate convergence toward global minimum energy configuration given system shown using appropriate statistical distribution quasi random pseudo random sampling methods compare well standard uniform grid based technique moreover combination random sampling uniform grid points maintaining sampling performance equilibrium calculations system significantly increases performance fictive component system elsevier rights reserved
failures engineering components traced back cyclic loads cause fatigue material cyclic loads either constant variable influence taken account fatigue analysis aim assure minimum required lifetime component without breakdown simultaneously lightweight design intended reducing size component strength materials cyclic loading essentially lower static loading however cyclic strength importance practical applications components fail cyclic loading static loads regrettably strength cyclic loaded components discovered relatively late first systematic investigations performed century cyclic loadings result mechanic thermal service loads superimposed static loads looking truck chassis loaded dead load vehicle due loading unloading procedures load changed quasi static way additional cyclic loads emerge driving operation addition static loads due braking acceleration cornering physical conditions like bumps roadway air drag additional loading also due resonance vibrations engine gearbox fuel tank spare wheel cyclic loads lead fatigue material hence overstraining crack cracks propagate finally lead failure component
investigation paper dimensional variable coefficient generalized shallow water wave equation bilinear forms backlund transformation lax pair obtained based bell polynomials symbolic computation one two three soliton solutions derived via hirota method one periodic wave solutions obtained via hirota riemann method discussions indicate one periodic wave solutions approach one soliton solutions propagation interaction soliton solutions discussed graphically find soliton amplitudes velocities related variable coefficients phase shifts two soliton solutions differences superposition two one soliton solutions amplitudes two soliton solutions equal sum corresponding two one soliton solutions
better understanding origin differentiation neurons medulla oblongata promote comprehension different neural systems functional importance including hypoglossal nucleus studies addressing histostructure morphometric parameters hypoglossal nucleus human embryos fetuses scientific literature aim establish structure morphometric parameters hypoglossal nucleus nerve cells form embryos human fetuses different gestational age materials methods morphological histological study human embryos fetuses weeks prenatal development carried results prenatal development hypoglossal nucleus weeks gestation neuroblasts changed spherical oval shape weeks polygonal nerve cells showing nucleus composition polygonal nerve cells become dominated week biggest area hypoglossal nucleus determined human fetuses gestational age weeks mean values nerve cells area largest weeks gestational age human fetuses mean values nerve cells nuclei largest weeks gestational age human fetuses conclusions intensive increase area hypoglossal nucleus identified human fetuses gestational age weeks weeks weeks weeks weeks weeks intensive increase mean neuroblasts area detected human fetuses gestational age weeks weeks decrease human fetuses gestational age weeks intensive increase mean area neuroblasts detected human fetuses gestational age weeks weeks
objective patients adhd suggested increased risks allergic diseases without consistent results limited studies association adhd autoimmune diseases noted literature method utilizing taiwan national health insurance research database adhd patients identified compared age gender matched controls results participants identified adhd increased prevalence allergic diseases including asthma odds ratio allergic rhinitis atopic dermatitis urticaria compared control group although comorbidity autoimmune diseases adhd low adhd patients significantly greater prevalence ankylosing spondylitis ulcerative colitis autoimmune thyroid disease controls conclusion results supported association adhd allergic autoimmune diseases studies required clarify underlying mechanisms
paper optimal adaptive robust pid controller based fuzzy rules sliding modes introduced present general scheme control mimo uncertain chaotic nonlinear systems control scheme gains pid controller updated using adaptive mechanism fuzzy rules gradient search method chain rule differentiation order minimize sliding surfaces sliding mode control precisely sliding mode control used supervisory controller provide sufficient control inputs guarantee stability control approach ascertain parameters proposed controller avoid trial error multi objective genetic algorithm employed augment performance proposed controller chaotic system duffing holmes oscillator andan industrial robotic manipulator case studies evaluate performance proposed control approach obtained results study regarding systems compared outcomes two notable studies literature results analysis prove efficiency proposed controller regard mimo uncertain systems challenging external disturbances terms stability minimum tracking error optimal control inputs elsevier rights reserved
shown problem evaluation states object controller arises digital control multi circuit embedded systems time intervals residence system state depends time complexity control algorithm dispatching discipline two simplest disciplines common use investigated cyclic dispatching foreground quasi stochastic one use semi markov process fundamental theory models functioning control programs investigated dispatching disciplines worked mathematical relationships time return state semi markov process time switches obtained parameters obtained essential working efficient regimes data processing embedded systems
objective determine contraceptive practices women surgical repair obstetric fistula assess determinants uptake pregnancy rate first year methods prospective cohort study enrolled women successful surgical repair obstetric fistula center nigeria patients followed year data obtained record review completion semi structured questionnaire results among participants aware contraception used contraceptive methods surgery commonly used methods male condom hormonal injections main reasons non use fear adverse effects women future desire children religious prohibition cultural beliefs partner disapproval risk unplanned pregnancy first year significantly lower among women used contraceptives among relative risk confidence interval conclusion contraceptive uptake birth control fistula repair surgery low socioeconomic reasons religious cultural beliefs myths resulting unplanned pregnancies international federation gynecology obstetrics published elsevier ireland ltd rights reserved
objective estimate health status utility preference weights hereditary angioedema hae attack attacks using data hereditary angioedema burden illness study europe hae bois europe survey utility measures quantitatively describe net impact condition patient life score reflects death reflects full health study design methods hae bois europe cross sectional survey conducted spain germany denmark assess real world experience hae patient perspective survey items overlapped conceptually euroqol dimensions domains pain discomfort mobility self care usual activities anxiety depression manually crosswalked corresponding population based utility weights utilities computed respondent hae bois europe survey acute attacks attacks results overall total hae bois europe participants completed selected survey items thus allowed computation based utilities mean utilities hae attack attacks respectively utilities acute attack dependent severity pain last attack pain mild pain moderate pain severe pain significant differences across countries mean utilities derived study approach compare sensibly disease states acute attacks attacks conclusion impacts hae translate substantial health status disutilities associated acute attacks well attacks documenting detrimental effects hae meaningful patient perspective results consistent across countries regard pain severity comparison similar disease states results used raise awareness hae serious disease wide ranging personal social impacts
background ectoine derivative hydroxyectoine cytoprotectants widely synthesized microorganisms defense detrimental effects high osmolarity cellular physiology growth ectoines possess ability preserve functionality proteins macromolecular complexes even entire cells attributes led description chemical chaperones consequence growing interest using ectoines biotechnological purposes skin care medical applications hydroxyectoine synthesized ectoine region stereo specific hydroxylation reaction mediated ectd enzyme member non heme containing iron oxoglutarate dependent dioxygenases chemical modification endows newly formed hydroxyectoine either superior different stress protecting stabilizing properties microorganisms producing hydroxyectoine typically contain mixture ectoines aimed establish recombinant microbial cell factory hydroxyectoine produced highly purified form secreted growth medium results used escherichia coli strain defective synthesis osmostress protectant trehalose chassis recombinant cell factory expressed strain plasmid encoded ectd gene pseudomonas stutzeri control anhydrotetracycline inducible tet promoter chose ectoine hydroxylase stutzeri cell factory careful comparison vivo performance seven different ectd proteins final set cell factory ectoine provided salt stressed cultures strain pmp ectd ectoine imported cells via osmotically inducible prop prou transport systems intracellularly converted hydroxyectoine almost quantitatively secreted growth medium experiments coli mutant lacking currently known mechanosensitive channels mscl mscs msck mscm revealed release hydroxyectoine osmotic steady state conditions occurred independently microbial safety valves shake flask experiments ectoine completely converted hydroxyectoine within conclusions describe recombinant coli cell factory production secretion chemical chaperone hydroxyectoine free contaminating ectoine
objectives effects air pollution parameters sulfur dioxide particulate matter values respiratory system investigated material methods data obtained daily air pollution classified two groups group coal burning years group natural gas coal burning groups divided two subgroups according months combustion combustible november april noncombustible may october number patients asthma chronic obstructive pulmonary disorder copd recorded results statistically significant difference groups within years values statistically different groups defined month number patients combustible noncombustible subgroups found different every years numbers patients copd asthma changed years strong correlation copd correlation found copd number visits copd asthma statistically different combustible noncombustible subgroups respectively values copd patients respectively contrast respectivley asthma patients conclusion air pollution known increase respiratory disease occurrences decrease usage solid fuel air pollution could reduced may effective preventing respiratory diseases
comes person perception one judge book cover perceivers made judgments liking personality based photograph unknown least month later made judgments following face face interaction person photograph based liking judgments predicted interaction based liking judgments lesser extent photograph based personality judgments predicted interaction based personality judgments except extraversion consistency liking judgments partly reflected behavioral confirmation perceivers favorable photograph based judgments behaved warmly toward target live interaction elicited greater target warmth explained least part consistency personality judgments reflecting halo effect remained robust even controlling perceiver effects target effects perceived attractiveness findings support view even read book one still extent judges cover
aim purpose study examine clients perspectives regarding helpful aspects pluralistic therapy depression method thirty nine clients received psychological treatment multi site study exploring alternative interventions standardised evidence based approaches eighteen consented face face telephone change interview end treatment change interviews aim elicit clients perspective regarding changes noticed therapy also possible causes changes descriptions transcribed analysed thematically using explicit coding themes audited research team findings data categorised three priori domains consisting specific themes first domain constitutes client originated helpful factors including clients positive perspectives therapy clients overall effort change clients contribution decision making process therapy therapists perceived helpful accepting respectful empathic responding clients needs making clients feel comfortable challenging empowering using techniques flexible reassuring treatment outcomes change perspectives behaviour response problems well increased insight also considered helpful factors therapy conclusion findings suggest clients pluralistic therapy active agents change willingness engage treatment crucial helping clients feel comfortable creating safe therapeutic environment challenging dysfunctional patterns associated depression empowering believe change possible reassurance non intrusive guidance considered beneficial
paper quantitatively evaluates performance adaptive gain parabolic sliding mode filter psmf removing noise feedback control mechatronic systems different parameter values noise intensities evaluation results show due nonlinearity psmf four performance measurements transient time overshoot magnitude tracking error computational time vary widely different conditions based evaluation results paper provides practical tuning guidelines psmf balance tradeoff among four measurements effectiveness guidelines validated numerical examples
context obesity major global health problem associated various adverse effects pharmacological interventions often necessary management obesity orlistat fda approved antiobesity drug potent inhibitor intestinal lipases objective current study orlistat evaluated genotoxic potential human lymphocyte cells vitro compared another antiobesity drug sibutramine presently withdrawn market due undesirable health effects caffeine intake may additional burden people using anorectic drugs therefore work needed carried evaluate possible effects caffeine orlistat induced dna damage materials methods human lymphocytes exposed orlistat sibutramine caffeine assess genotoxicity comet assay vitro addition lymphocytes incubated caffeine single concentration orlistat results orlistat sibutramine genotoxic concentrations tested sibutramine genotoxic caffeine found genotoxic concentrations treatment orlistat non genotoxic concentrations caffeine lead decrease dna damage discussion conclusion orlistat induce dna damage human lymphocytes vitro caffeine found reduce orlistat induced genotoxicity
spain need improve chronic hepatitis care among people inject drugs pwid injecting drug use important risk behaviour hepatitis virus hcv infection review sources relevant published literature mapped size addiction hcv population spain experts opioid use disorder oud treatment spain completed consensus define population size hcv prevalence access barriers hepatitis treatment pwid populations spain individuals lifetime history injecting drugs currently individuals spain oud many injected drugs year individuals engage treatment services oud proportion group continues inject drugs high hcv prevalence pwid estimates spain uptake hepatitis therapy pwid spain limited barriers include awareness treatment pathways advocacy regular screening effective joint care urgent need address barriers effective hepatitis care pwid spain practical specific strategies including peer led solutions patient buddy systems joint working models local level make important short term differences copyright wolters kluwer health inc rights reserved
article presents comparative longitudinal analysis situation spanish portuguese italian women since beginning crisis study follows three specific objectives expose female labor market three states analyze women labor participation perspective precariousness analyze position women men gender relations perspective gender inequality research prepared technique documentary analysis secondary sources official statistics conclude crisis affected women southern european countries similar manner greater compliance traditional gender roles time differences observed result different economic structures labor legislation social protection regimes
rituximab monoclonal chimeric antibody approved food drug administration immunotherapy non hodgkin lymphoma bexxar zevalin two approved radiolabeled antibodies radioimmunotherapy non hodgkin lymphoma however murine origin reduces treatment efficacy circumvent efforts made radiolabel rituximab various therapeutic radioisotopes present study effort made optimize conjugation bifunctional chelating agent antibody radiolabeling procedures preparation clinical scale labeled rituximab attempt also made prepare freeze dried rituximab kit easy convenient clinical translation agent clinical scale rituximab mci gbq prepared radiochemical purity using kit biological evaluation rituximab performed vitro cell binding studies raji cell lines showed satisfactory binding degrees degrees pharmacokinetic behavior agent evaluated biodistribution studies normal swiss mice revealed high blood liver uptake initial time points although exhibited slow gradual clearance time study indicates clinical scale rituximab could conveniently formulated using methodology described present article
migraine aura subtype migraine characterized transient neurological disturbances usually precede headache cortical spreading depression csd likely pathophysiological correlate aura phase migraine found common rare forms migraine familial hemiplegic migraine csd depolarization wave propagates across cerebral gray matter transiently suppressing neuronal activity prophylactic treatments migraine topiramate valproate reduce number csd events evaluated changes gene expression rat cortex brainstem inducing csd cortex without prophylactic treatment topiramate valproate csd induction showed similar transcriptomic profiles without treatment cortex involving genes related hormone stimulus apoptosis synaptic transmission interleukin signaling brainstem csd without treatment although lesser extent also induced gene expression changes involving genes related apoptosis half genes altered brainstem csd also differentially expressed direction cortex differences gene expression identified csd consequence treatments neither cortex brainstem perspective results suggest early triggering csd similar consequences seen genetic level without prophylactic treatment gene expression changes induced csd cortex brainstem may help better understand underlying mechanisms identify targets therapeutic approaches american pain society
nightlight new desktop application designed visualize astronomical data primary motivation program apply modern user interface design advancements ubiquitous fits file general sense wish demonstrate usefulness desirability employing modern commercial frameworks use scientific code general description initial version program presented well future development directions
division summation sigma digital control three phase inverters achieve active reactive power injection presented overcome limitation abc frame transformation however sigma control requires four sets control laws cover four quadrant operations namely grid connection power factor similar rectification correction leading similar lagging similar moreover switching sequences four modes also different increasing complexity firmware programming paper improvement control law derivation region selection sigma digital control presented selecting zero crossing points phase voltages region transitions control laws related parameter tables four modes unified general form switching sequences four modes also unified switching pattern grid connectionmode additionally sigma transformation matrix identified simplify derivation procedure division summation sigma obtain control law directly measured results kva phi bidirectional inverter presented confirm improvement
study author uses parametric models predict track geometry induced dynamic behavior vehicle characteristics vehicle dynamics models directly identified spatial opposed frequency domain one former merits identify characteristics vehicle dynamics fewer observed points use spectral analysis making easier obtain fewer data set identification another determine parameters represent dynamic behavior vehicle using statistical criteria models predict vertical acceleration vehicle wheel load well estimate track conditions taking account ride comfort operating safety
paper presents triple mode optimize settling current consumption noise crystal oscillator xtal proposed xtal driver three mode fast settling mode used reduce settling time reduce start time xtal driver internal noise booster inb negative resistance booster nrb proposed simulated start time mhz xtal driver cmos reduced retention mode operated stand reduce total power consumption peak low detection pld proposed stand xtal driver effect load therefore pld blocks input supply voltage hvt signal goes reduces power consumption emi reduction mode proposed reduce output spur noise reduce output spur noise pseudorandom number generator prng used makes bits random signal spread frequency mode controlled digital control block inverter amplifier driver optimized reduce power consumption gets ppm operation changing temperature degrees degrees
teachers students often consider learning programming difficult pursuit face face learning alone provide effective teaching efficient solutions learning case teaching model make students active programming courses even relies solid learning theory pedagogical strategies paper reports study based case teaching model programming laboratory animal system las standalone case management laboratory animals paper includes overview las architectural design user interface presents design implementation evaluation model well implications learning computer programming case method provides interactive learning environment students based survey student feedback students learn programming gain knowledge quickly effectively using case teaching model traditional methods teaching elsevier ltd rights reserved
order better understand hydrodynamics valve trays air water operation industrial scale tower diameter consisting two valve trays studied experimental results clear liquid height froth height average liquid holdup dry pressure drop total pressure drop weeping entrainment investigated empirical correlations presented three dimensional computational fluid dynamics cfd simulation eulerian framework valve tray ansys cfx software done drag coefficient used cfd simulations calculated data obtained experiments simulation results found good agreement experimental data industrial scale objective work study extent experimental cfd simulations must used together prediction design tool industrial trays
backgroundin recent years superior accuracy maternal plasma cell free dna based prenatal screening resulted national decline amniocenteses chorionic villus sampling cvs creating new implications specialist training objectiveto compare annual figures amniocenteses cvs tertiary hospital national population based trends methodsretrospective study examining amniocentesis cvs procedures performed tertiary hospital numbers procedures indications testing type test diagnostic results analysed trends annual numbers procedures compared national population based data medicare benefits schedule database resultsthe annual numbers diagnostic procedures tertiary centre fell study period representing decline significantly smaller corresponding national decline period ultrasound abnormality including nuchal translucency surpassed high risk screening results common indication invasive testing thirty percent procedures performed ultrasound abnormality occurred prior weeks gestation conclusionour tertiary centre experienced relatively smaller decline prenatal diagnostic procedures compared national figures largely due increase testing ultrasound abnormalities results demonstrate increasing contribution first trimester ultrasound detection fetal abnormalities cell free dna era continued viability specialist training invasive procedures
paper presents method determination minimal stable realisation fractional continuous time linear system different fractional orders proposed method digraph based algorithm constructed paper shown perform transfer matrix using electrical circuits consisting resistances inductances capacitances source voltages proposed method discussed illustrated numerical examples
work tcad based optimization channel radius performed considering line edge roughness ler node gate around gaa nanowire fet channel radius scaled confronted seriously reduced driving current due two major factors one small channel carrier density induced quantum effect mobility degradation induced thickness fluctuation surface phonon scattering first time guideline channel radius high performance studied statistical analysis ler performed considering thin layer model tlm covers mobility degradation induced scattering thin layer
solar aided power generation technology low grade solar thermal energy used displace high grade heat extraction steam regenerative rankine cycle power plant feedwater preheating purpose displaced extraction steam expand steam turbine generate power power plant using concentrated solar thermal energy displace extraction steam high pressure temperature feedwater heaters displaced feedwater heaters popular arrangement namely extraction steam low pressure temperature feedwater heaters non displaced feedwater heaters displaced solar thermal energy solar aided power generation plants solar radiation input changes extraction steam displaced feedwater heaters requires adjusted according solar radiation however extraction steams non displaced feedwater heaters either adjusted accordingly following called constant temperature strategy unadjusted following called constant mass flow rate strategy solar radiation input changes previous studies overlooked operation non displaced feedwater heaters also impact whole plant performance paper aims understand reveal impact two different operation strategies non displaced feedwater heaters plant performance paper rankine cycle power plant extraction steam high pressure temperature feedwater heaters displaced solar thermal energy used study case purpose found plant adopting constant temperature strategy generally better adopting constant mass flow rate strategy however rich solar energy available adopting constant mass flow rate strategy achieve better performance elsevier ltd rights reserved
impairments metacognitive capacity core barrier recovery many borderline personality disorder metacognition refers processes enable individuals access understand integrate ideas mental states others use information recognize respond adaptively psychological challenges borderline personality disorder believed amenable psychotherapy established treatment protocols specifically target metacognitive capacity case illustration provides descriptive account individual borderline personality disorder long term institutional setting participated months novel psychotherapy specifically targeted metacognitive processes metacognitive reflection insight therapy vital elements intervention elaborated examples case illustration case conceptualization outcomes potential prognosis also presented discussed
creation network organization firm multifarious task especially large number nodes middle boxes security nodes integrated network paper introduces integration abe algorithm virtual network security called netsecvisor order achieve authentication users involved network confidentiality data transmitted received virtual network redeems administrators network designers complexity reducing number devices required specific workstation take input various policies pertaining packets sent also including various routing rules response techniques malicious attacks attribute based encryption abe algorithm used improve security existing virtual network security called netsecvisor abe algorithm uses attributes known participants involved transmission reception packets helps ease process creation retrieval keys encryption decryption notwithstanding performance security enhanced virtual network
despite intensive research spondyloarthritis pathogenesis important questions still remain unanswered particularly concerning enthesis new bone formation several evidences suggest prevalently occurs endochondral ossification however remains identify factors induce influence initiation progression recent progress achieved animal models vitro genetic association studies led hypothesize several systemic factors adipokines gut hormones local factors bmp wnt signaling well angiogenesis mechanical stress involved critically review summarize available data delineate possible mechanisms involved enthesis ossification particularly spinal ligament level key messages complete understanding spondyloarthritis pathophysiology requires insights inflammation bone destruction bone formation located entheses lead together ankylosis functional disability several factors probably play role pathogenesis bone formation entheses including cytokines also several systemic factors adipokines gut hormones local factors bmp wnt signaling well angiogenesis mechanical stress data available pathophysiology new bone formation spondyloarthritis limited often conflicting future studies needed better delineate develop new therapeutic approaches
contrast enhanced ultrasound ceus sensitive imaging technique assess tissue vascularity particularly useful early detection grading arthritis recent study shown gamma variate accurately quantify synovial perfusion flexible enough describe many heterogeneous patterns however cases heterogeneity kinetics even gamma model properly describe curve high number outliers work apply ceus data single compartment recirculation model scr takes explicitly account trapping microbubbles contrast agent adding single gamma variate model integral scr model originally proposed dynamic susceptibility magnetic resonance imaging solved pixel level within bayesian framework using variational bayes also include automatic relevant determination ard algorithm automatically infer model complexity scr gamma model data demonstrate inclusion trapping best describes ceus patterns pixels best fitted single gamma results highlight necessity use ard automatically exclude irreversible component supported data ard returns precise estimates majority kinetics total percentage pixels limited computational time average min per subject moreover impact additional trapping component evaluated differentiation rheumatoid non rheumatoid patients means support vector machine classifier backward feature selection results show trapping parameter always present selected feature set improves classification
six experiments involving total participants conducted investigate relative effectiveness repeated evaluative pairings rep exposure category members paired pleasant unpleasant images evaluative statements verbally signaling upcoming pairings without actual exposure combination rep shifting implicit social nonsocial attitudes learning modality rep rep varied participants implicit attitudes assessed using implicit association test iat study used fictitious social groups niffs laaps study used novel social groups humans long square faces study used nonsocial stimuli squares rectangles study study used known social groups young elderly american foreign effective rep less superior rep producing implicit attitude change results robust across social nonsocial domains known novel groups study eliminated time intervention levels construal expectancy effects possible explanations findings associative theories implicit evaluation posit implicit attitudes shift piecemeal time yet experiments one shot language based learning led larger shifts implicit attitude exposure stimulus pairings moreover redundancy observed rep suggests attitude acquisition repeated pairings evaluative instructions may rely shared mental representations
internal model control imc based pid controller widely used industrial control problems scheme provides good compromise among set point tracking disturbance attenuation robustness therefore paper propose simple technique design imc pid controller illustrate utility proposed technique different types linear nonlinear second order systems approximated second order models higher order systems simulated proposed approach depicts quick response set point change good disturbance attenuation optimal performances class problems compared conventional imc pid existing popular techniques beauty paper need highly complex mathematical approaches using simple conventional imc approach improved servo regulatory results achieved
paper presents application actor model control braking torques wheels articulated vehicle untripped rollover manoeuvre numerical model articulated vehicle dynamic optimisation used calculate appropriate braking torques wheel order restore stability optimisation problem requires equations motion integrated optimisation step time consuming therefore parallel computing using actor model system proposed actor model system implemented genetic algorithm paper formulation genetic algorithm actor system results obtained dynamic optimisation presented compared
sensitive rapid sandwich immunoassay developed human lipocalin lcn functionalizing koh treated polystyrene microtiter plate multiwalled carbon nanotubes mwcnts dispersed aminoproyltriethoxysilane aptes significantly increased surface area due presence mwcnts led high immobilization density ethyl dimethylamino propyl carbodiimide edc activated anti lcn capture antibodies anti lcn bound mtps stable weeks stored pbs degrees detects lcn limit detection lod limit quantification loq respectively assay offered similar fold lower lod similar fold faster compared commercial sandwich enzyme linked immunosorbent assay kit elsevier rights reserved
proteomic analyses facilitate interpretation molecular biomarker probes helpful diagnosing schizophrenia current study attempt test whether potential differences plasma protein expressions bipolar disorder associated cognitive deficits underlying brain structures forty two plasma proteins patients patients non clinical controls quantified analysed using multiple reaction monitoring based triple quadrupole mass spectrometry approach also computed group comparisons protein expressions patients controls patients well potential associations protein levels cognitive functioning psychomotor speed executive functioning crystallised intelligence well underlying brain volume hippocampus explored using bivariate correlation analyses main finding study apolipoprotein expression differed patients controls alterations disease groups putatively related cognitive impairments well hippocampus volumes however none protein level differences related clinical symptom severity summary altered apolipoprotein expression linked cognitive decline underlying morphological changes disorders results suggest detection molecular patterns association cognitive performance underlying brain morphology great importance understanding pathological mechanisms well supporting diagnosis treatment disorders
polycythaemia vera essential thrombocythaemia primary myelofibrosis pmf represent typical myeloproliferative neoplasms mpn usually characterized specific somatic driver mutations jak calr mpl jak haplotype telomerase reverse transcriptase gene tert single nucleotide polymorphism snp could represent large fraction genetic predisposition seen mpn snp tagging jak haplotype tert snp genotyped mpn patients known jak calr mpl status controls jak haplotype strongly correlated jak positive mpn lesser extent calr positive mpn tert snp strongly correlated mpn regardless phenotype pmf major molecular subtype jak calr positive variants significant contribution nuanced consequences jak predisposing essentially jak positive mpn tert general non specific effect mpn regardless phenotype major molecular subtype
paper presents method evaluate computational cost function embedded systems method uses least squares method useful see sample time choice feasibility control applications work developed method used evaluate computational cost model based predictive control speed control shunt direct current motor method tested using two embedded devices allowing find correct sample time device evaluated
talking energy conservation rebound effect always concerned defined increasing energy consumption relative counterfactual predicted technological progress efficiency induced decrease real price energy services paper try find way figure calculating substitution relations accord definition based trans log cost function considering asymmetric impact energy cost share equation paper applies allen uzawa substitution elasticity establish price oriented analysis diagram fossil energy consumption using time series data applying joint method dynamic ols dols seemingly unrelated regressions sur china electricity generation sector estimated results showed china electricity generation sector allowing asymmetric price effects indicates china power generation sector generally displays feature energy saving
menopause estradiol primarily synthesized peripheral tissues enzyme aromatase encoded cypa cypa variation associates circulating estradiol postmenopausal women variation best represented intronic variant variation appears pleiotropic effects also associates endometrial cancer risk indeed estradiol plays important role development breast endometrial cancer aromatase inhibitor drugs used treatment diseases however response rates ais low currently way identify breast endometrial cancer patients likely receive clinical benefit multiple studies proposed genetic variation cypa effects efficacy eight candidate variant studies sample size greater describe associations cypa variation outcome patients treated ais nominally significant associations patient outcome reported several variants including however association time progression replicated independent study moreover also variant association patient outcome passes multiple testing threshold variant linkage disequilibrium supporting hypothesis associations patient outcome may driven effects circulating estradiol despite preliminary evidence well phenotyped comprehensively genotyped patient sets need studied conclusions drawn effects cypa variation efficacy
many institutions offering online courses part regular schedule provide flexible course offerings students hope cost savings end paper focus examining students ratings comments reported student rating teaching effectiveness srte surveys online introductory programming course past years look issues identified play role srte surveys online course examine teaching several different perspectives include effectiveness appropriateness online courses students paper includes set specific general recommendations address legitimate students concerns believe would make course delivery effective enjoyable students
second three part paper nonfatal occupational injuries united states part focuses injuries back data bureau labor statistics bls used examine injury statistics different regions back including spine spinal column lumbar region injuries multiple back regions injuries different regions back categorized common measures magnitude number incidence rates major industrial classifications different types events exposures contact objects slip fall accidents overexertion injuries etc different natures injuries sprains strains fractures bruises etc different sources injuries parts materials worker motion healthcare patient etc different occupations service technical sales administrative support etc age injured ethnic origin injured gender injured length service injured employer number lost workdays relevance industry paper provides focused specific information injuries united states knowledge back injury trends essential instituting efforts control elsevier science rights reserved
paper novel covert channel called covert behavior channel proposed according behaviors network users solve security efficiency problem traditional covert channel proposed channel operation sequences network protocols used carriers covert information encryption based information embedding scheme designed improve security covert information help markov model capacity proposed covert channel time varying noise derived formulation analyzing covert behavior channel presented channel noise aroused discarding packets introducing corrected entropy based algorithm detect covert behavior channel security channel verified numerical results show proposed covert behavior channel secure covert storage channels achieves better bit rate robustness covert timing channels copyright john wiley sons ltd
global drive low carbon dioxide environment well secure affordable energy supply encouraged nuclear power play core role energy mix landscape today houses eight large nuclear plants reactors reported generate electricity two thirds electricity generation capacity retired need replaced low carbon dioxide reliable power future improve energy security meet commitments carbon dioxide emissions targets cumulative growth nuclear capacity forecast comparison coal oil gas still leaving nuclear share global capacity considerable scope nuclear long term
paper cmos low power high speed low error four quadrant analog multiplier based simple current squarer circuit presented new squarer circuit consists mos transistor operating saturation region resistor proposed multiplier balanced structure composed four squarer cells simple current mirror performance proposed design simulated using hspice software tsmc cmos technology simulation results supply voltages show linearity error bandwidth mhz thd mhz maximum static power consumption respectively monte carlo analysis variations channel width length gate oxide thickness threshold voltage transistors resistance values also performed verify satisfactory robustness reliability proposed work
provide opportunities educational scientific development also poses challenge era traditional teaching methods meet manpower needs new curriculum reform requires renewing teaching ideas changing teaching methods reflect students subjectivity study cultivation students innovative spirit formed awareness capability lifelong learning inquiry teaching cultivate students innovative spirit practical ability objective reflect respond demand education era effective means implementation new curriculum
background prenatal anxiety depression distressing expectant mother adverse effects fetus subsequently child study aimed determine whether listening specially composed songs would effective intervention reducing symptoms prenatal anxiety depression methods pregnant women recruited online randomly assigned one two groups music group daily listening specially composed songs control group daily relaxation weeks self report questionnaires used assess symptoms state trait anxiety spielberger depression edinburgh postnatal depression scale epds trait anxiety measured primary outcome state anxiety depression secondary outcomes participants randomised group participants intervention group participants active control group completed study results music group demonstrated lower trait anxiety effect size state anxiety effect size epds effect size scores week compared baseline paired test changes control group conclusions though pilot study high levels attrition results suggest regular listening relaxing music explored effective non pharmacological means reducing prenatal anxiety depression
introduction change migraine headache preexisting change development novo known potential complications following percutaneous closure atrial septal defect asd consensus causal trigger remains elusive objectives expose potential triggers linked mainly timing occurrence emergence novo change preexisting subsequent percutaneous asd closure pasdc methods literature systematically searched studies available english reporting status pasdc published january november determined number percentage patients experiencing status change within days post procedure cumulative total final follow mdn months results twenty five studies met inclusion criteria accounted total pasdc patients pre procedure prevalence change preexisting occurred total within days pasdc within follow improved resolved persisted novo incidence ranged incipience within days pasdc females accounted gender differentiated cases type distinguished cases without aura aura improved resolved persisted beyond final follow antiplatelet agents effective modulators studies possible adverse predisposing traits scarce larger asd size reported patients experiencing novo preexisting exacerbation short aortic rim reported three novo patients allergic response occluder nickel alloy four patients status change baseline novo preexisting change specified interpretation early intensification status change later amelioration virtually paralleling stages endothelialization relatively high efficacy antiplatelet agents emergence dominant novo type favor proinflammatory triggers status change pasdc
removing child parental care important difficult decision make far reaching consequences child family whilst plethora literature relation child protection practice generally research decision making minimal practice paper present decision making criteria assist practitioners make decisions child removal important child protection practitioners apply set principles consider factors making decisions criteria follows severity abusive incident presence cumulative harm whether perpetrator access child functioning parent whether perpetrator responsible child abuse intimate partner violence past cooperation parent intent perpetrator age child functioning child voice expressed wishes child protective relationships available child statutory requirement cause harm referring criteria assist practitioners clear explicit reach decision result greater consistency outcome children families
internal shear strength geosynthetic clay liners gcls evaluated direct shear testing accordance astm specific set boundary conditions given normal stress order prevent slippage gcl gripping system interface ensure internal shear failure gcl gripping surface made spikes tall mounted rigid substrate recommended standard method commonly used recognized certain boundary effects exist result aggressive gripping system improve hydraulic performance protect bentonite core multi component gcl designed thin membrane film laminated glued one carrier geotextiles necessary investigate boundary effect multi component gcl internal shear strength tests film membrane geotextile interface prone interference rough gripping surface recommended current standard series internal shear strength tests conducted multi component gcl product different gripping conditions found tests using aggressive gripping system yield significantly higher peak shear strength multi component gcl lower residual shear strength large displacements
diffusion solution phenomena heterogeneous atomics binary metallic liquid solid interface wide range applications materials engineering structures properties diffusion solution zone play important influence final product quality therefore study formation mechanism new intermetallic phases interface prediction control structure diffusion solution zone important theoretical practical significance according heat treatment experimental results liquid solid interfaces formation mechanism intermetallic compounds binary metallic liquid solid interface analyzed moreover cohesive energy formation heat stable intermetallic compounds room temperature binary system calculated based empirical electron theory solids molecules prediction criterion new phase formation order interface given predicted results new phase formation order liquid solid interfaces based criterion agree well experimental results
sleep one basic human needs vital role normal development growth however sleep loss prevalent problem among school children adolescents leading multiple academic health consequences children adolescents hong kong greater academic pressure stress found sleep lesser western counterparts several local studies consistently demonstrated hong kong schoolers sleep deprived school days extensive sleep compensation weekends combat prevalent situation sleep education program aiming promoting healthy sleep practices needed paper review rationale efficacy experiences large scale school based sleep education program hong kong summary group conducted clustered randomized school based educational program multilevel multimodal sleep education program including town hall seminar small class teachings slogan painting competitions development sleep education website findings study conducted secondary schools suggested school based sleep education program effective increasing sleep knowledge improving behaviors psychological health well healthy lifestyle practice adolescents improve sleep wake pattern adolescents
monitoring data civil structures mainly include load temperature induced structural responses traditional damage detection methods use vibration based structure responses eliminating temperature effects measured data article new structural damage identification method using temperature induced responses proposed applied long span suspension bridge novelty method derives structural transfer function taking temperature load variation temperature induced strains input output data thus able accurately reveal inherent structural characteristics unlike traditional methods use structural vibration responses ambient testing proposed method temperature induced strain separated measured strain responses ensemble empirical mode decomposition eemd technology euclidean distance based damage index defined uses temperature variations temperature induced strains structural damage detection numerical analysis results successfully verify feasibility proposed method used evaluate condition long span suspension bridge ship collision use monitoring data performance bridge normal operating conditions also evaluated proposed method use long term monitoring data including temperatures strains american society civil engineers
careful examination skin soft tissues routine part forensic autopsy identify characterise traumatic lesions three cases reported benign vascular lesions presented bruises case year old man history epilepsy found dead floor dissection neck revealed haemorrhagic area mmx deep left thyrohyoid muscle case year old man found dead plastic bag head attached opened cylinder nitrogen gas mucosal surface upper lip apparent blue purple bruise case examination back month old girl revealed apparent bruise histological examination three lesions revealed benign vascular lesions absence microscopy lesions would considered traumatic origin raising possibility inflicted trauma
background anticonvulsants considered second line option bipolar disorder known abrupt withdrawal rarely related demyelinated lesions splenium corpus callosum oxcarbazepine used bipolar disorder although stated data sheet clinical case presented case years old woman bipolar disorder treated lithium oxcarbazepine presented manic episode confusional syndrome stopped taking medication magnetic resonance showed restricted diffusion area splenium corpus callosum bifrontal hygromas disappear two weeks later conclusions results study suggest patient presenting mild encephalopathy reversible splenial lesion one consider whether related withdrawal oxcarbazepine
paper exp function method generalized solve first order nonlinear differential equation forth degree nonlinear term result three new exact solutions free parameters obtained first two include generalized hyperbolic function solutions generalized trigonometric solutions special cases third one rational solution shown generalized exp function method help computer symbolic computation provides straightforward effective mathematical tool solving nonlinear differential equations
background forty six percent individuals mental health conditions long term physical illness individuals long term physical conditions mental illness physical psychiatric comorbidities significant concern medical psychiatry primary care services policy strategy literature highlighting need better address interface simulation training proposed tool improve clinicians management physical psychiatric comorbidities study first evaluate interprofessional simulation improving management comorbidity method participants doctors nurses emergency medical psychiatric community services across primary secondary care south london quantitative qualitative measures completed one day interprofessional simulation course addressing clinical care physical psychiatric comorbidities results knowledge confidence attitudes scores showed statistically significant improvements post course large effect sizes thematic analyses highlighted development interprofessional working clinical skills reflective practice leadership teamwork communication skills conclusion simulation training potential improve professional development clinical practice participants reporting increased abilities provide better care patients physical psychiatric comorbidities exemplifying case increased simulation training health care education international nursing association clinical simulation learning published elsevier inc rights reserved
entropy generation due natural convection calculated wide range rayleigh number laminar turbulent flow regimes diameter ratio isothermal vertical cylinder fitted annular fins laminar regime entropy generation predominantly caused heat transfer conduction convection viscous contribution negligible respect heat transfer turbulent regime entropy generation due fluid friction significant enough although heat transfer entropy generation still dominant results demonstrate degree irreversibility higher case finned configuration compared unfinned one deployment merit function combining first second laws thermodynamics tried delineate thermodynamic performance finned cylinder natural convection defined ratio finned unfinned ratio finned unfinned gets minimum value optimum fin spacing maximum heat transfer occurs turbulent flow whereas laminar flow ratio finned unfinned decreases continuously increase number fins
paper proposes systematic approach isolate quantify electromagnetic forces torques two distinct parts electric motor approach based decomposition magnetic field components generated different magnetized current carrying motor parts forces torques exerted field components computed using conventional force torque formulas proposed decomposition applied squirrel cage induction motor permanent magnet synchronous motor examples magnetic fields decomposed according current carrying conductors magnetized iron permanent magnets thereafter torques exerted fields specified results predict part pairs motor produce desired undesired behavior example torque torque ripple respectively
introduce algorithms conceptual circuits nonlinear differential limiters ndls outline methodology use mitigate band noise interference especially technogenic man made origin affecting various real complex vector signals interest limiting performance affected devices services given frequency linear filter affects noise signal interest proportionally linear filter used suppress interference outside passband interest resulting signal quality invariant type amplitude distribution interfering signal long total power spectral composition interference remain unchanged linear filter converted ndl introducing appropriately chosen feedback based nonlinearity response filter ndl may reduce spectral density particular types interferences signal passband without significantly affecting signal interest result signal quality improved excess achievable respective linear filter behavior ndl filter degree nonlinearity controlled single parameter manner enables significantly better overall suppression noise compared respective linear filter especially noise contains components technogenic origin adaptive configurations ndls similarly controlled single parameter suitable improving quality non stationary signals time varying noise conditions ndls designed fully compatible existing linear devices systems used enhancement low cost alternative state art interference mitigation methods
equation oriented approach widely used process simulation optimization nevertheless large scale models consist huge number nonlinear equations make solution procedure challenging time consuming task gradient based numerical algorithms function evaluations dominant step solution procedure parallel computation method developed function evaluations within optimization strategies dividing equations several groups function evaluations calculated using multiple threads parallel hardware platform simultaneously theoretical analysis speedup ratio conducted implementation proposed method multi core processor platform well graphics processing unit gpu platform presented several case studies numerical results compared discussed show multi core processor implementation good computational performance whereas gpu implementation achieves computational acceleration relatively specific conditions elsevier ltd rights reserved
current industrial practice thousands industrial alarms generating millions alarm events built digital control systems typically found power generation facilities power grid communication networks oil refineries petrochemical plants manufacturing plants given increasing complexity systems effective approach managing alarms stream data generate becomes imperative hitherto much alarm management techniques mostly rule based intensive engineering domain expertise requiring understanding underlying physical processes special skills part plant operator paper describes novel graph based data mining approach used analyze industrial alarm data method leverages availability large timestamped historical alarm events datasets using historical datasets developed graph analytics model identifies redundant alarms series alarms associated leading critical events experiments using real world power generation station oil refinery industrial alarm datasets demonstrate proposed method scalable efficient
type collagen peptides prepared hydrolysis type collagen protein different enzyme combinations study found peptides obtained papain pepsin trypsin combination hydrolysis strongest anti ray capability collagen peptides carboxymethyl chitosan cmc cacl microspheres prepared emulsification method used investigate effects mice skin damages vitro vivo vitro experiments indicated cmc cacl microspheres protective effect ray irradiated damages mice thymus lymphocytes mice skin surface texture morphological histomorphological analysis showed consistent result cmc cacl microspheres played certain role prevention irradiated skin damages could also improve ultraviolet prevention ability besides preventive function better repair function possible improve preventive function skin photoaging play better effectiveness cosmetic skin care adding cmc cacl microspheres make cosmetics natural antioxidant resource
biological based bbcam methods complementary alternative medicine cam may interact cancer treatments reduce efficacy enhance adverse effects although cam usage evaluated well cancer entities data melanoma patients still missing aim study determine cam usage melanoma patients using standardized questionnaire identify potential interactions established new systemic melanoma therapies multicenter study carried seven german skin cancer centers routine care contact cam usage former current melanoma treatment assessed melanoma patients probability interaction classified four categories ranging interaction unlikely possible likely iii data questionnaire filled patients eligible evaluation cam usage reported melanoma patients took bbcam vitamins trace elements supplements phytotherapeuticals patients former current therapy used bbcam melanoma treatment included interferon radiotherapy chemotherapy braf inhibitor tyrosine kinase inhibitors ipilimumab basis model likelihood interaction found cancer therapy also using bbcam risk interactions main limitation study reliable comprehensive database clinical relevant interactions cam oncology exists patients receiving melanoma specific treatment using bbcam methods risk interactions raises concerns safety treatment efficacy patients protect melanoma patients potential harm combination cancer treatment cam usage patients systematically encouraged report cam use oncologists trained evidence cam patient guidance saver cam use copyright wolters kluwer health inc rights reserved
autonomy adaptability key features intelligent agents many applications intelligent agents control ambient intelligence environments autonomous intelligent robotic systems require processing information coming many available sensors produce adequate output responses changing scenarios autonomy cases applies ability agent produce correct outputs without human guidance also ubiquity portability low power consumption integrability sense embedded electronic system implementation paradigm applied design autonomous intelligent agents order satisfy mentioned characteristics however processing complex computational intelligence algorithms tight delay constraints resource constrained low power embedded systems challenging engineering problem paper single chip intelligent agent based computationally efficient neuro fuzzy information processing core described system endowed information preprocessing module based principal component analysis pca permits substantial reduction input space dimensionality little loss modeling capability moreover pca module tested means achieve deep adaptability changing environment dynamics endow agent fault tolerance presence sensor failures data driven trials research data set obtained experimental intelligent inhabited environment used benchmark system elsevier rights reserved
virtual reality based learning framework electrical discharge machining edm presented research architecture supports hands exercise precision manufacturing field distance education allows learners practice access edm based virtual environment means internet research open source software tools virtual interactive technology available integrated develop emulated effective learning environment distance education
appreciation key component subjective well may contribute positive mental health studies examined relationships specific aspects appreciation dimensions positive mental health thus aim study identify associations aspects appreciation positive mental health appreciation positive mental health measured korean university students females using appreciation inventory mental health continuum short form results obtained showed focus significantly predicted emotional well focus loss adversity significantly predicted social well focus expression nature daily life significantly predicted psychological well implications results might enable positive mental health enhanced discussed
sessile organisms octocorals avoid threats predation parasitism fungal infections evasive responses instead rely strategies deter reduce impact threats one strategy development hard structures sclerites minute calcium carbonate skeletal elements located top ectoderm within mesoglea gastrodermal tube walls sclerites multiple roles including structural support colony protection predators role sclerites physical barrier deters fungal infection however unknown study examines potential role sea fan sclerites protection fungal infection accomplish four different fungi isolated healthy sea fans inoculated tubes filled culture media sclerites healthy diseased fans placed top determine whether chemical compounds sclerites impact infection sclerites healthy diseased fans extracted several days acetone prior inoculation results showed sclerite layer delayed fungal infection reaching agar compared controls tubes agar sclerites difference tubes healthy diseased sclerites differences among sclerites extracted acetone study suggests addition roles structural support predator deterrence sclerites play role physical chemical barriers fungal infection elsevier rights reserved
shortage common many markets human organs blood problem often difficult solve price adjustment given safety ethical concerns paper study two non price methods often used alleviate shortage human blood first method informing existing donors current shortage via mobile message encouraging donate voluntarily second method asking patient family friends donate family replacement program time shortage using individual donation records across years large chinese blood bank show methods effective addressing blood shortage short run different implications total blood supply long run compare efficacy methods discuss applications different scenarios alleviate shortage published elsevier
fluid flow along semi infinite plate small periodic irregularities surface considered large reynolds numbers boundary layer double deck structure thin boundary layer lower deck classical prandtl boundary layer upper deck aim paper prove existence uniqueness stationary solution rayleigh type equation describes oscillations vertical velocity component classical boundary layer
current research tested utility responsible gambling tool provides players personalized behavioral feedback play hypothesized player estimated monetary loss less actual monetary loss subsequent expenditures reduced end players enrolled casino based loyalty program asked much lost three month period whilst using loyalty card provided player account data results indicated players estimated losses thbse lost money thought time perceive reduced play month follow period however data actual play indicated significantly reduced amount wagered well amount lost follow period given informed decision making raison etre responsible gambling tools results suggest providing players accurate information much spend gambling moderate gambling expenditures authors published elsevier ltd
diisononyl phthalate dinp member phthalate family used plasticize polyvinyl chloride pvc chemical known enhance airway inflammation ova induced asthma model adjuvant effects aggravate allergic dermatitis moreover dinp enhances production interleukin activated cells however effect dinp differentiation naive cells helper cells vitro allergic asthma vivo yet studied study dinp shown suppress polarization enhance polarization naive cells vitro also dinp induced allergic asthma via production ige igg reduction ifn gamma igga finally confirmed exposure dinp induces infiltration inflammatory cells pas positive cells increases expression caspase caspase asthmatic mice conclusion suggest dinp environmental pollutant endocrine disruptor ecd induces asthma via modulation equilibrium production mediated cytokines immunoglobulin elsevier rights reserved
studies intensive mothering suggest fulfilling societal expectations good mother diminishes maternal psychological well however studies tend focus young mothers examine association intensive mothering psychological well using sample mothers midlife drawn national survey midlife development united states intensive mothering measured provision high levels emotional support children high degree thought effort put relationships reduction paid work provide care psychological well measured depressive symptoms self rated mental health positive negative affect ordinary least squares regression results mixed providing high levels emotional support predicts depressive symptoms worse self rated mental health higher negative affect higher investments thought effort predict better mental health
organization members engage moral objection taking principled stand ethically questionable activities help prevent activities persisting unfortunately research suggests also may perceived less warm pleasant nice members comply ethically questionable procedures article draw role theory explore legitimate power influences observers responses moral objection argue individuals expect high legitimate power engage moral objection expect low legitimate power comply ethically questionable practices propose contrasting role expectations influence extent moral objectors perceived warm subjected social sanctions insults pressure unfriendly behavior test predictions experiments study draws participants prior workplace experiences supports first section mediated moderation model negative association actor moral objection compliance observers warmth perceptions weaker actor high rather low legitimate power effect mediated observers met role expectations study online experiment featuring biased hiring task reveals warmth perceptions fostered behavior legitimate power interaction influence observers social sanctioning intentions finally study laboratory experiment exposes participants unethical behavior virtual team task replicates study findings extends results actual well intended social sanctions
recco control algorithm presented article based fuzzy rule based frb system named anya non parametric antecedent part starts zero fuzzy rules clouds rule base evolves structure performing control plant consequent part recco pid type controller used parameters adapted online manner recco require line training type model controlled process differential equations moreover article propose normalization cloud data space improved adaptation law controller due normalization evolving parameters fixed new adaptation law improves performance controller starting phase process control assess performance recco algorithm firstly comparison study classical pid controller performed model plate heat exchanger phe tuning pid parameters done using three different techniques ziegler nichols cohen coon pole placement furthermore practical implementation recco controller real phe plant presented phe system nonlinear static characteristic time delay additionally real sensor actuator limitations represent serious problem control point view besides recco control algorithm autonomously learns evolves structure adapts parameters online unsupervised manner elsevier rights reserved
nitrate pollution severe problem urban aquatic systems especially within megacity undergoing rapid urbanization mostly sewage supposed prevailing source dual isotope approach delta delta applied explore variation isotopic signatures sewage processed wastewater treatment plants wwtps beijing found raw treated sewage owned different isotopic signatures including delta aeuro degrees delta aeuro degrees raw sewage well delta aeuro degrees delta aeuro degrees treated effluents wwtp processing would result enrichment isotopic compositions discharged effluents concentrations increasing besides advanced sewage treatment technology pollutant reduction may raise heavier isotopic compositions isotope value ranges urban sewage manure separated seasonal tighter isotope value ranges supposed improve accuracy source apportionment isotope value ranges conducted study might provide useful information tracing sources towards implementation efficient water pollution control beijing
paper construct general darboux transformation sasa satsuma equation represent iterated solutions terms three component wronskian iterated solution derive breather well single double hump solitons also analyze three types collisions soliton soliton breather breather soliton breather collisions surprising result soliton breather collision may exhibit shape changing phenomena one breather soliton may change soliton breather interacting another breather novel collision phenomena may applied optical information processing optical switching routing optical signals
aims clozapine effective medication treatment refractory schizophrenia however descriptions mental health comorbidity profile care experiences people clozapine routine clinical settings scarce using data australian survey high impact psychosis aimed examine proportion people using clozapine compare clozapine users antipsychotic users demographic mental health adverse drug reaction polypharmacy treatment satisfaction variables methods data describing people diagnosis schizophrenia schizoaffective disorder reported taking antipsychotic medication previous weeks drawn representative australian survey people psychotic disorders contact mental health services previous months compared participants taking clozapine taking antipsychotic medications range demographic clinical treatment related indicators results one quarter participants clozapine participants chronic course illness one third clozapine adjusting diagnosis illness chronicity participants taking clozapine significantly lower odds current alcohol cannabis drug use despite similar lifetime odds metabolic syndrome diabetes common among people taking clozapine chronic pain less common psychotropic polypharmacy differ groups conclusions consistent international evidence clozapine underutilisation large number participants chronic illness high symptom burden taking clozapine lower probabilities current substance use chronic pain among clozapine users warrant study
background observed cases extensive osteolysis femoral head following acetabular fractures even though original fracture involve femoral head neck observation called massive osteolysis femoral head mofh purpose evaluate clinical imaging features mofh gain better understanding patho etiology material methods retrospectively collected cases acetabular fractures seen period years evaluated clinical features imaging characteristics findings compared features complications osteonecrosis rapidly progressive osteoarthritis post traumatic osteolysis results fifteen patients ratio mean age years mofh prevalence motor vehicle collision falls common mechanisms injury time interval developing mofh range months initial injury patterns femoral head osteolysis varied eccentric cases transcervical cases four cases eccentric osteolysis developed high degree osteolysis mofh observed near surgical hardware cases one biopsy specimen reveal typical features osteoarthritis avascular necrosis conclusion mofh appears distinct entity avascular necrosis rapidly progressive osteoarthritis suggested mofh variant post traumatic osteolysis evident subset patients
multi level factors act concert influence child weight related behaviors study examined simultaneous impact variables obtained level home environment mealtime ritualization parent modeling child satiety responsiveness outcomes practicing healthy limiting unhealthy child behaviors phcb lucb respectively low income sample cross sectional study caregivers preschool children caregivers interviewed using validated scales structural equation modeling used examine associations outcomes adjusting study region demographics caregiver body mass index found significant associations phcb higher mealtime ritualizations beta confidence interval parental modeling beta less parental restrictive behavior beta parental covert control beta parental overt control beta less parental permissive behavior beta significantly associated lucb findings suggest synergistic effects mealtime ritualizations covert control environmental level parental modeling overt control restrictive permissive behavior parent level outcomes factors modifiable support multidisciplinary interventions promote healthy child weight related behaviors elsevier ltd rights reserved
background little detailed evidence available integrated policies could impact population health conditions policies could realized aim study assess youth alcohol consumption trends province noord brabant netherlands related development implementation integrated policies methods retrospective multiple case study alcohol policies six municipalities stronger declines youth alcohol consumption cases compared four municipalities weaker declines controls information policy process period obtained semi structured depth interviews policy advisors information implemented interventions extracted policy documents checked interviewees interviews analyzed thematic content results municipalities stronger declines alcohol consumption involved sectors public health started implement interventions use regulatory enforcement strategies involvement facilitated framing youth alcohol consumption safety rather health problem whereby local media played substantial role implementation integrated policies facilitated dedicated leadership sufficient resources conclusions reductions youth alcohol consumption noord brabant stronger municipalities started develop integrated policies results suggest integrated policies framing health problem broader societal problem could positively influence population health
single nucleotide polymorphism snp kbp upstream ilb gene shown influence dynamics cytomegalovirus cmv replication allogeneic stem cell transplant recipients allo sct investigated whether snp effect dynamics cmv specific cell immunity patients cmv ifn gamma cells enumerated flow cytometry patients prior cmv dnaemia group onset cmv dnaemia group donor ilb genotype determined real time pcr plasma levels quantitated elisa cmv specific cell counts plasma levels patients group significantly different among ilb genotype groups patients harboring donor ilb genotype appeared expand cmv specific ifn gamma cells higher level response viral replication counterparts fewer patients group received pre emptive antiviral therapy overall significant inverse correlation observed median levels measured prior cmv dnaemia onset level cmv specific cells enumerated detection cmv dnaemia summary data suggested protective effect attributed snp minor allele could mediated least part eliciting robust cmv specific cell responses wiley periodicals inc
portfolio optimization problem multi objective optimization problem necessary consider benefits also consider risks optimal situation achieve least risk maximum return papers define portfolio optimization problems analyze shortcomings existing portfolio model corresponding solution ideas introduce multi objective genetic algorithm demonstrate feasibility multi objective genetic algorithm application portfolio algorithm design process detailed process constructing building portfolio investment line actual situation put forward five objective optimization model angles reasonable optimized simulation test select algorithm selected number programs better overall performance program
paper analyses discrete hydraulic systems emphasis hydraulic parameter analysis pump turbine power plant developed model could make hydro electric power plants transient behavior studies easy accurate especially complicated systems simulation developed based analog mathematical models transient phenomenon equations hydroacoustic modeling method governing equations transient flows solved based equivalent electrical circuits defined different equipments system using kirchhoff voltage law final equivalent circuit system set nonlinear ordinary differential equations generated unsteady friction loss visco elastic behavior pipe fluid considered pipelines model set nonlinear ordinary differential equations generated using implicit scheme equations nonlinear odes solved using fourth order runge kutta method validation carried experimental values also mathematical model francis pump turbine developed transient behavior two different cases hydraulic systems including pump turbine investigated results logically correct acceptable method efficient overall simulation hydro power plants including turbine generator transformer
based similarities overconsumption food addictive drugs increasing interest food addiction compulsive eating pattern defined using symptoms parallel substance use disorders impulsivity multidimensional construct robustly linked drug addiction increasingly examined obesity determinant mixed findings study sought clarify relations three major domains impulsivity impulsive personality traits discounting delayed rewards behavioral inhibition obesity food addiction based association impulsivity compulsive drug use general hypothesis impulsivity food addiction relation would stronger responsible impulsivity obesity relation using cross sectional dimensional design participants obese completed biometric assessment yale food addiction scale yfas upps impulsive behavior scales nogo task measures monetary delay discounting results revealed significantly higher prevalence food addiction among obese participants stronger zero order associations impulsivity indices yfas compared obesity two aspects impulsivity independently significantly associated food addiction composite positive negative urgency reflecting proneness act impulsively intense mood states steep discounting delayed rewards furthermore results supported food addiction mediator connecting urgency delay discounting obesity findings provide evidence linking impulsivity food addiction obesity suggest food addiction may candidate etiological pathway obesity individuals exhibiting elevations domains elsevier ltd rights reserved
recommendation system useful tool employed identify potential relationships items users electronic commerce systems consequently remarkably improve efficiency business topic enhance accuracy recommendation attracted much attention researchers past decade many methods accomplish task introduced however complex calculations normally necessary achieve higher accuracy suitable real time system hence paper propose weight based item recommendation approach provide balanced formula recommended accuracy computational complexity proposed methods employ newly defined distance describe relationship users items recommendations predictive algorithms developed data analysis based movielens datasets indicates methods applied obtain suitable prediction accuracy maintain relatively low computational complexity
aims objectivesthe aim study evaluate effectiveness therapeutic conversation intervention group caregiver sessions supporting role caregivers backgroundcaregivers people eating disorders known suffer major difficulties great need support unhelpful parental support strategies delay recovery individual eating disorder skill training interventions equip parents skills guidance techniques helping support person making one important links treatment process designthe therapeutic conversation intervention consisted five group caregiver sessions three booster sessions calgary family assessment calgary family intervention models illness beliefs model new maudsley method used theoretical frameworks content intervention consisted work difficult behaviours feelings helpful strategies participants included primary secondary caregivers year old patients eating disorders eight caregivers dropped treatment methodsthis study quasi experimental design one pre two post test measures resultsbetween caregivers rated therapeutic conversation intervention supportive furthermore study revealed significant differences caregiver emotional cognitive support illness beliefs disruptive behaviour quality life negative aspects care giving demands caregiver patient behavioural difficulties intervention follow conclusionstherapeutic conversation intervention caregivers group private sessions proved beneficial relevance clinical practicethis outcome provides information healthcare professionals help primary caregivers supporting role turn improve services healthcare centres psychiatric hospitals
backgroundexercise nutrition psychological interventions may positive impacts frailty sarcopenia however known whether integrated care programme three components beneficial intensity programme also certain study aim determine effectiveness two levels integrated care frailty sarcopenia methodsa randomized control trial conducted two community hospitals taiwan older adults years age scored cardiovascular health study phenotypic classification frailty chs pcf enrolled trial low level care llc participants received education course frailty sarcopenia coping strategy nutrition demonstration study exercise programme educational multimedia material distributed reference home practice monthly telephone follow ups adherences high level care hlc participants addition llc instructions received six sessions site problem solving therapy exercise sessions within months brief nutrition consultation also provided exercise sessions primary outcome improvement chs pcf least one category pre frail robust frail pre frail robust baseline secondary outcomes included changes individual frailty sarcopenia indicators assessments done months trained research assistants blinded randomization status intention treat analysis applied resultsmean age years females entire cohort improvement primary outcome months increased months remained stable months improvement rates similar groups compared llc group hlc participants greater improvements following indices energy expenditure walking walking time dominant hand grip strength timed test one leg stand time mainly month assessments conclusionsthe month integrated care improved frailty sarcopenia status among community dwelling elders high intensity training yielding greater improvements low level care could promoted basic intervention hlc could reserved high risk high motivation
electrochemical biosensing used detect specific analytes fluids bacterial chemical contaminants common implementation electrochemical readout potentiostat usually includes potentiometric amperometric impedimetric detection recently several researchers developed small low cost single chip silicon based potentiostats advances heterogeneous integration technology low power potentiostats implemented paper similar low cost substrates paper deals design low power paper based amperometric front end low cost rapid detection environment amperometric detection voltage signal provided sensor system small current value generated electrochemical redox reaction system measured order measure low current values noise circuit must minimized accomplished pre amplification front end stage typically designed around operational amplifier core appropriate circuit design low power low cost amperometric front end identified taking heterogeneous integration various components account operational amplifier core bare custom cmos chip integrated onto paper substrate alongside commercial shelf electronic components general purpose low power two stage cmos amplifier circuit designed simulated ams process layout design verification submitted multi project wafer manufacturing run simulated results bandwidth mhz common mode rejection ratio power dissipation comparable analytical values
viral load monitoring hepatitis virus hcv necessary diagnose infection monitor response therapy tests involved currently confined specialist institutions need fast accurate assay limited operator input enhance access viral load monitoring evaluated quantification hcv rna serum plasma cepheid xpert hcv viral load assay comparison abbott realtime hcv assay serum plasma samples gathered hcv infected individuals four international sites tested xpert hcv viral load assay results compared quantification abbott realtime hcv assay external quality assessment panel eight samples also tested total samples analyzed study qualitative results agreed two platforms samples analysis samples quantified tests showed strong correlation correlation coefficient across quantifiable range bland altman plot data showing mean difference standard deviation log external quality assessment panel xpert hcv viral load assay results quantified log per milliliter within standard deviation target value one sample also similarly misquantified abbott realtime hcv assay xpert hcv viral load assay performs well compared market leading hcv viral load test considered instances rapid near patient testing required
growing body research teenage motherhood foster care largely focused risks involved mother child yet mothers depict much complex picture experience becoming mothers current study employed interpretative phenomenological analysis explore depth qualitative interviews six participants meaning experience motherhood among teenage mothers foster care years immediately ageing study focused particular dimension motherhood participants efforts break cycle child abuse neglect children two themes emerged characteristic experiences treating children well parenting differently avoiding system reducing isolation enhancing support given increased likelihood children teen mothers particularly maltreated becoming involved child welfare system study findings suggest possible strategies disrupting cycles intergenerational child welfare involvement generated young mothers practice implications addressing possible substance abuse mental health relational parenting needs discussed
type diabetes chronic pro inflammatory autoimmune disease consisting islet infiltrating leukocytes involved pancreatic beta cell lysis one promising treatment islet transplantation however clinical application constrained due limited islet availability adverse effects immunosuppressants declining graft survival islet encapsulation may provide immunoprotective barrier preserve islet function prevent immune mediated rejection transplantation previously demonstrated novel cytoprotective nanothin multilayer coating islet encapsulation consisting tannic acid immunomodulatory antioxidant poly vinylpyrrolidone pvpon efficacious dampening vitro immune responses involved transplant rejection preserving vitro islet function however ability pvpon maintain islet function vivo reverse diabetes tested recent evidence demonstrated modulation redox status affect pro inflammatory immune responses therefore hypothesized transplanted pvpon encapsulated islets restore euglycemia diabetic mice provide immunoprotective barrier results demonstrate pvpon nanothin coatings significantly decrease vitro chemokine synthesis diabetogenic cell migration importantly pvpon encapsulated islets restored euglycemia transplantation diabetic mice results demonstrate pvpon encapsulated islets may suppress immune responses enhance islet allograft acceptance patients elsevier ltd rights reserved
salmonella typhi chronically persist within gallbladder patients suffering gallbladder diseases study intended improve understanding bacterial mechanisms underlying bile adaptation revealed bile bactericidal agent led generation reactive oxygen species typhi salmonella typhi response showed significant increase production anti oxidative enzymes namely superoxide dismutase catalase work reports quorum sensing system typhi regulates level enzymes oxidative stress support observations quorum sensing mutant typhi found sensitive bile significantly lower levels anti oxidant enzymes compared clinical isolates furthermore addition exogenous cell free extracts cfes typhi containing quorum sensing signalling molecule significantly increased levels enzymes within mutant interestingly cfe addition significantly restore biofilm forming ability mutant strain compared wild type presence ciprofloxacin ampicillin typhi formed persister cells increased fold presence bile thus system typhi aids oxidative stress management enhanced persister cell populations could assist chronic bacterial persistence within gallbladder
objective aim study investigate associations serum zinc incident metabolic syndrome components middle aged older finnish men methods prospective follow study conducted among men kuopio ischaemic heart disease risk factor study old baseline main outcome incident metabolic syndrome defined national cholesterol education program ncep criteria outcomes individual components ncep metabolic syndrome fasting blood glucose serum triacylglycerols serum high density lipoprotein hdl cholesterol hypertension waist circumference results average follow men developed metabolic syndrome highest tertile serum zinc higher risk confidence interval trend across tertiles develop metabolic syndrome compared lowest tertile adjustment several potential confounders association serum zinc incident metabolic syndrome attenuated adjustment waist circumference serum hdl cholesterol hypertension serum zinc also directly associated higher waist circumference hypertension inversely associated hdl cholesterol examinations conclusions found direct association serum zinc incidence metabolic syndrome middle aged older eastern finnish men studies warranted explore mechanisms elsevier inc rights reserved
background controversy ability patients alzheimer disease experience remember emotional stimuli study aims assess emotional experience patients existence emotional enhancement memory also investigated influence affective state processes methods sixty pictures international affective picture system administered participants patients controls participants performed immediate free recall recognition tasks positive negative affect schedule used assess participants current affect results patients identified valence unpleasant pictures better others pictures experienced arousing patients controls recalled recognized higher number emotional pictures neutral ones patients discriminated better unpleasant pictures mood congruent effect observed emotional experience memory positive affect associated better immediate recall liberal response bias conclusion patients identify emotional content stimuli especially unpleasant ones emotional enhancement memory preserved affective state explain differences processing memory emotional items patients controls
performance wireless industrial process plant affected wired wireless link reliability recent related works focus mainly wireless link reliability paper focuses wired link reliability controller wireless highway addressable remote transducer wirelesshart node control application process plant fast sampling wired link delay short message transmissions node could occur concurrently resulting packet collision packet dropout thus leading local contention cause process plant critical control application unstable therefore paper proposes effective design exponentially weighted moving average filter mitigate contention effect improve process plant performance order make evident validate existence local contention experiment carried using wirelesshart device experiment controller delay estimated packet dropout simulation results designed filter show significant improvement process performance terms percentage overshoot compared performance process plant using traditionally optimized pid controller
background many healthcare organizations developed disclosure policies large scale adverse events including veterans health administration study evaluated national large scale disclosure policy identifies gaps successes implementation methods semi structured qualitative interviews conducted leaders hospital employees patients nine sites elicit perceptions recent large scale adverse events notifications national disclosure policy data coded using constructs consolidated framework implementation research cfir results conducted interviews insights included handle communication large scale disclosures multiple levels large healthcare organization manage ongoing communications event employees cfir constructs sub constructs assessed seven prominent interviews leaders employees specifically mentioned key problem areas involving networks communications disclosure organizational culture engagement external change agents disclosure need reflecting evaluating policy implementation disclosure patients shared preferences personal outreach phone place current use certified letters interviewees discussed issues execution costs disclosure conclusions cfir analysis reveals key problem areas need addresses disclosure including timely communication patterns throughout organization establishing supportive culture prior implementation using patient approved effective communications strategies disclosures providing follow support employees patients sharing lessons learned
study proposes third person perception tpp viewed type comparative social judgment domain media influence function assimilation contrast anchoring mechanisms process social comparison derived hypotheses tested web based experimental data results showed evidence tpp function assimilation contrast effects also evidence anchoring effects effects tended emerge self anchor implication directions future research tpp discussed
present work proposes novel method detection estimation outliers particle image velocimetry measurements modification temporal coefficients associated proper orthogonal decomposition experimental time series using synthetic outliers applied two sequences vector fields method benchmarked state art approaches recently proposed remove influence outliers compared methods proposed approach offers increase accuracy robustness detection outliers comparable accuracy estimation
paper presents novel method assessing local structural identifiability question general non linear state space model method combination application singular value decomposition parametric output sensitivity matrix created simply integrating model symbolic computation reduced model guided svd results allows confirmation conclusions regarding identifiability obtained first step case lack identifiability symbolic computation quickly results determination exact structure nullspace suitable parametrisation method discussed detail applied three case studies last two considerably large containing parameters identified respectively elsevier ltd rights reserved
adolescents united states known sleep deprived early school start times biological propensity stay late variety wake inducing activities lead teens often sleep enough chronic lack sleep measurable negative effects health well adolescents though research documented adolescent sleep behavior studies addressed perceptions sleep purpose study identify common sources sleep information sample southwestern adolescents examine general message content delivered adolescents source convenience sample adolescents mean age completed semi structured person interview october november tucson arizona high school participant observation brief questionnaire regarding parent behavior used triangulate results parents teachers cases media stressed importance sleep teens friends typically complained tiredness individual experiences sleep reported shape future sleep behavior rationales adequate sleep included value placed alertness health achievement improving sleep adolescents require education sleep messengers negative health consequences inadequate sleep larger cultural shift healthy sleep teenagers conceived prioritized schools families adolescents elsevier ltd rights reserved
innovation involves metabolic health monitor mhm app using self adaptive individualized stochastic mathematical models capture dynamic slow changes trajectories metabolism goal observing controlling fat weight lean body mass insulin resistance notably canonical representation metabolism created expressed daily energy density lean body mass change daily energy density fat mass change ratio lean body mass change velocity fat mass change velocity ratio three parameters serve metrics dynamic changes trend prediction fat mass lean body mass insulin resistance changes allow intra interindividual comparisons make possible self directed therapy optional web based feedback healthy lifestyle team real time feedback predicted dynamic changes metabolic parameters allow user make appropriate modifications diet physical activity realizing adaptive self control dietary exercise regime lifestyle change fight obesity insulin resistance shown control engineering point view canonical representation assures full observability controllability proof concept clinical observability controllability provided simulation studies using clinical trial data first time otherwise difficult measure parameters daily utilized macronutrient energy intake macronutrient oxidation rate daily changes fat weight lean body mass insulin resistance realized minimum error variance supported kalman filter
paper introduces systematic methodology applying mason signal flow graph analysis feedback circuits demonstrate relationships among signals feedback circuits represented intuitive graphical manner utilizing signal flow graphs constructed desired solutions achieved simple inspection signal flow graph thevenin norton equivalent circuits utilized model loading effects feedback network example circuits presented
brca mutation carriers high risk breast ovarian cancer age ranges respectively additionally women brca mutation associated breast cancer also elevated risk secondary malignancies fortunately breast ovarian cancer outcome brca mutation carriers least good non carriers chemoprevention prophylactic surgeries appropriate use therapies therefore identification might mutation important genetic counseling testing screening prevention strategies applied timely manner article reviews impact genetic testing general timing genetic testing diagnosis prior knowledge mutation status brca carriers newly diagnosed breast cancer additionally risk reducing surgeries including prophylactic contralateral mastectomy bilateral salpingo oophorectomy sensitivity brca defective breast cancer cell lines differential chemotherapeutic agents discussed elsevier ltd rights reserved
nondestructive evaluation methods rely prior knowledge expected interaction ultrasonic waves defects inform detection characterization decisions wavefield imaging refers measurement signals originating spatially fixed source rectilinear grid applied visualize effect subsurface scatterer surface measured wave motion obliquely incident shear waves directed far surface plate containing hole using well known anglebeam ultrasonic inspection method laser vibrometer laboratory scanner used record resulting plane motion plate surface vicinity hole far surface corner notch introduced subsequently enlarged waves scattered notch isolated incident hole scattered waves via baseline subtraction wavefields scattered wavefields filtered frequency wavenumber domain separate rayleigh shear longitudinal contributions scattered wavefield filtered wavefields interpolated space obtain radial wavefield slices originating base notch radial slice analyzed quantify scattering function observation direction resulting rayleigh shear longitudinal scattering profiles notch size results compared four different notch sizes two transducer orientations
reliance interdisciplinary health care teams meeting multidimensional needs community becomes greater new interdisciplinary education programmes learning experiences needed educate students health care professionals become better team players joseph community health center sjchc model community based interdisciplinary health care team education developed support mcmaster university educational centre aging health clinical teaching unit without walls sjchc model structured one session week eight consecutive weeks elective learning experience students six eight senior health social science health related students work two group facilitators team discussion theme topics team dynamics role issues professional values collaboration conflict communication leadership power client centred goal oriented care consumerism issues success impact sjchc model measured several primary secondary outcomes outlined charting outcomes educational clinical approaches coeca model
evolution genes related sex reproduction fish shows high plasticity date sex determination system identified species solea senegalensis chromosomes chromosome system sex determination related species show zwsystem next generation sequencing ngs multi color fluorescence situ hybridization mfish techniques bioinformatics analysis carried objective revealing new information sex determination reproduction senegalensis end several bacterial artificial chromosome bac clones contain candidate genes involved processes dmrt dmrt dmrt dmrt sox sox sox sox cypaa amh vasa aqp nanos analyzed compared region related species synteny studies showed localization dmrt dmrt drmt largest metacentric chromosome senegalensis coincident found chromosome cynoglossus semilaevis would potentially make sex proto chromosome phylogenetic studies show close proximity senegalensis oryzias latipes species system sex master gene comparative mapping provides evidence preferential association candidate genes particular chromosome pairs using ngs mfish techniques possible obtain integrated genetic map shows chromosome pairs senegalensis least one bac clone result important distinguishing chromosome pairs senegalensis similar shape size mfish analysis shows following localizations chromosomes dmrt dmrt dmrt dmrt sox thrb aqp sox cypaa fshb igsfb sox lysg sox
metamaterials artificial structures exhibit different electromagnetic properties contrary known materials one features discovered recent years performing perfect absorption incident electromagnetic wave metamaterial absorbers property used stealth technology remote sensing applications significant range electromagnetic spectrum microwave optics according radar cross section relevant targets representing visibility radar reduced coating target metamaterial absorber paper design simulation measurements novel band metamaterial broadband absorber investigated primarily dual band metamaterial absorber obtained depending superposition different neighboring resonant frequencies differently sized unit cells super cell metamaterial absorber demonstrated band due optimization size location unit cell broadband metamaterial absorber designed frequency range ghz observed simulation results good agreement measurements least radar cross section reduction metamaterial absorber compared fully metallic plate comparable dimensions demonstrated numerically experimentally frequency range fire control surveillance radars
carbon emission reduction policies demand tighter building life cycle assessment lca qualification standards however widely believed difficult efficiently reduce carbon emissions buildings fragmentary revision qualification standards reason korean government developed green building index certification system gbi certification system certification framework based primarily upon carbon emissions building currently assessment program tailored gbi certification system purpose study develop building life cycle carbon emissions assessment program begas support korea gbi certification system theoretical consideration gbi certification system building lca qualification standards international green building certification systems analyzed analyses enabled development begas reflects characteristics gbi certification system current state korea construction industry consequently appropriate building life cycle carbon emissions assessment program developed support korea gbi certification system effectively elsevier ltd rights reserved
hanger installation important constructing self anchored suspension bridges installation plan obtained comparative studies concerned information tentative construction steps comparisons generally performed manually using detailed nonlinear finite element method nfem particularly curved cables however procedure complex time consuming thus study proposes efficient method analyze mainly concerned parameters hanger installation plan automatically optimized strategy updating ideal construction steps developed yield plan totally linear coordinate iteration realize indiscrimination coordinate rod model icrm combined coordinate iteration based methods cims proposed modeling construction steps icrm simulates major deformation system total bridge specific rods cims identify equilibrium linear algorithms solve coordinates directly basis nfem avoided design efficiency greatly improved plan effectiveness proposed method demonstrated comparison case studies field test verification application discussion real scale bridge elsevier ltd rights reserved
enteric diseases frequently occur rabbits around weaning leading extensive use antibiotics rabbit breeding context breeders well consumers ask alternative strategies improve health animals maintenance gut health complex relies delicate balance mucosa including absorptive epithelium digestive immune system gut microbiota environmental factors including diet firstly immune non immune mechanisms protection pathogens gut presented relation installation composition gut microbial ecosystem rabbit role health finally several strategies stimulate digestive immune system favour beneficial microbiota exclude enteric pathogens discussed several nutrients including fatty acids fibres implicated development immune response could used improve immune ability animals dietary fatty acids ratio could interest rabbit role dietary fibre digestive health demonstrated weaned rabbits strong relations fibre supply cal microbiota evidenced works also reported influence fibre level diet given young weaning health status rabbits weaning therefore nutritional needs suckling rabbits especially fibre requirements enhance subsequent gut health need thoroughly studied relation needs mothers exogenous flora could also added diet stimulate digestive immune system prevent development enteric pathogens finally vaccines permit protection host specific pathogens elsevier rights reserved
straight back syndrome rare condition usually associated mitral valve prolapse pseudo heart disease caused narrow anterior posterior chest due loss normal dorsal curvature thoracic spine rarely narrowed upper chest may compress trachea causing extrinsic tracheal obstruction severe enough requires operative repair effectively opening upper chest variety techniques allow trachea enough room avoid compression
background violence leads homicide results extreme financial emotional burden society juveniles commit homicide often tried adult court typically spend majority lives prison despite enormous costs associated homicidal behavior serious neuroscientific studies examining youth commit homicide methods use neuroimaging voxel based morphometry examine brain gray matter incarcerated male adolescents committed homicide compared incarcerated offenders commit homicide two additional control groups used understand nature gray matter differences incarcerated offenders commit homicide matched important demographic psychometric variables healthy participants community results compared incarcerated adolescents commit homicide incarcerated homicide offenders reduced gray matter volumes medial lateral temporal lobes including hippocampus posterior insula feature selection support vector machine learning classified offenders homicide non homicide groups overall accuracy conclusions results indicate brain structural differences may help identify highest risk committing serious violent offenses authors published elsevier inc open access article license
background house dust mite hdm allergens common cause allergy allergic asthma comprehensive analysis proteins targeted cells implicated development regulation allergic disease independent antibody reactivity still lacking objective comprehensively analyse hdm derived protein targets cell responses hdm allergic individuals investigate correlation ige igg responses protein function methods proteomic analysis liquid chromatography tandem mass spectrometry hdm extracts identified distinct protein clusters corresponding known allergens novel proteins peripheral blood mononuclear cells pbmc hdm allergic individuals stimulated hdm extracts assayed set similar peptides derived protein clusters predicted bind common hla class types immunoblots made parallel elucidate ige igg reactivity putative function analyses performed silico according gene ontology annotations results analysis cell reactivity revealed large number cell epitopes overall response magnitude frequency comparable known novel proteins antigens nine novel dominating total cell response known allergens dominant cell level also ige reactive expected novel dominant cell antigens ige reactive among known allergens hydrolase activity detectable ige igg reactivity strongly correlated protein function correlates immunogenicity novel proteins total epitopes accounted half total cell response underlining heterogeneity cell responses hdm allergens conclusions clinical relevance herein define cell targets known allergens novel proteins may inform future diagnostics immunotherapeutics allergy hdm
background aim study assess tolerability efficacy novel myrliq ginkgo biloba vitamin based nutraceutical product migraine headache without aura mhwa tension type headache tth methods open label prospective trial conducted adult subjects genders assigned two groups according diagnosis ihs guideline criteria mhwa tth subjects take days event headache attack period months severity pain measured visual analogue scale vas blood drawn determine interleukin tnf plasma levels quality life assessed asking subject fill questionnaire simplified version baseline days treatment subjects asked report recurrences results reduced vas score average two thirds groups mhwa tth improvement pain associated important improvement quality life reduced three cytokines significantly highest reductions recorded tnf consistently pronounced tth subjects recurrence rate mhwa subjects tth subjects adverse events reported conclusions thanks presence myrliq possesses anti inflammatory analgesic anesthetic properties considered alternative therapeutic option two common types headache namely mhwa tth
introduction global plans hiv aids committed reducing number countries punitive laws criminalizing key populations study explores whether punitive laws associated countries performance targets set global plans methods study used chi square tests independence explore associations legal status key population size estimates hiv service coverage countries used data reported countries united nations global aids progress report garpr indicators legal data unaids undp civil society organizations due lack sufficiently reliable legal data men sex men msm could studied study utilized public data aggregated national level correspondence individual experts subset countries stated purpose study responses anonymized results discussion significantly larger proportion countries criminalize sex sexual behaviour reported implausibly low size estimates size estimates msm consistent findings qualitative research msms marginalized reluctant studied countries sex sexuality criminalized size estimates often used denominators national hiv service coverage reports initially countries criminalized sex sexuality appeared higher hiv testing coverage among msm countries criminalized however investigation subset countries reported hiv testing coverage among msm found based implausibly low absent size estimates conclusions criminalization sex sexuality associated implausibly low absent msm size estimates low size estimates may contribute official denial existence msm failure adequately address needs inflated hiv service coverage reports paint false picture success enable measure progress hiv response agencies lead collaborative process systematically independently rigorously gather data laws enforcement
consider problem allocating cost transmission system among load generator entities known instance classical cooperative game theoretic problem solve problem formidable task dealing combinatorial game transferable utilities hard problem therefore suffers curse dimensionality marginal pricing pragmatic alternative solve problem since kirchhoff current law voltage law strictly adhered however generic complexity cooperative game theoretic problems wished away manifests difficulty choosing economic slack bus may even dispersed propose application min max fairness policy solve problem give algorithm run polynomial time network cost allocation min max fairness policy minimizes maximum regret among participating entities step maximum regret measured terms price lexicographic application principle leads fair unique equilibrium price vector results large network demonstrate fairness well tractability proposed approach
image segmentation important processing many applications image retrieval computer vision one successful models image segmentation level set methods based local context methods though comparatively effective segmenting images inhomogeneous intensity considerably computation intensive risk falling local minima convergence active contour energy function address issues propose region based level set method called mlbf based multi scale local binary fitting mlbf kullback leibler divergence first apply multi scale theory local binary fitting model build mlbf energy term measured divergence regions segmented incorporated energy function mlbf mlbf utilizes cluster distance adaptive kernel function selection strategy formulate energy function robust initial location contour classical segmentation models mlbf deal blurry boundaries noise problems results experiments synthetic real images shown mlbf improve effectiveness segmentation ensuring accuracy accelerating minimization energy function
recently rapid development smart phones mobile internet network security important people daily life paper network security scanning system based android wscan proposed aims make sure users mobile terminals secure network environment using devices system composed wifi scanning router tracking port scanning running service detection virus killing real time communication functions integrates java technology eclipse platform sqlite database using nmap toolkit system wscan provide valuable information running services opening ports mobile devices based android
studies whether vitamin insufficiency linked depression healthy young women despite women high rates problems female undergraduates living pacific northwest fall winter spring academic terms completed center epidemiologic studies depression ces scale weekly weeks measured serum levels vitamin ascorbate control variable blood samples collected vitamin insufficiency lower vitamin predicted clinically significant depressive symptoms across beta controlling season bmi race ethnicity diet exercise time outside evidence lower levels depressive symptoms fall participants winter spring explained higher levels vitamin depressive symptoms predict change vitamin levels findings consistent temporal association low levels vitamin clinically meaningful depressive symptoms preventive value supplementation tested elsevier ireland ltd rights reserved
pseudopolyps well described entity literature even though exact pathogenesis formation completely understood considered non neoplastic lesions originating mucosa repeated periods inflammation ulceration associated excessive healing processes occurrence less common crohn disease ulcerative colitis overall prevalence ranges moreover found often colon detected parts gastrointestinal tract well size exceeds arbitrary point classified giant pseudopolyps clinical evaluation differentiate pseudopolyps polypoid lesions dysplasiaassociated mass lesion situation represents ongoing clinical challenge pseudopolyps provoke complications bleeding obstruction management includes medical therapy endoscopy surgery however consensus exists optimal treatment approach patients pseudopolyps considered intermediate risk colorectal cancer regular endoscopic monitoring recommended review literature provide proposed classification characteristics pseudopolyps
background period infancy spanning neonatal stage two years characterized series health challenges affected child concerned parents study conducted odeda local government area ogun state nigeria aimed investigating plants used traditional management infantile dermatitis neonatal skin infections emphasis role spices methods structured questionnaires personal interview administered nursing mothers age range herbsellers age range lga herbsellers prescribed recipes used management general skin diseases including abscess chicken pox eczema flaky skin spots measles rashes ringworm small pox results survey yielded plants belonging families forming polyherbal mono recipes fabaceae rutaceae euphorbiaceae annonaceae poaceae meliaceae amaryllidaceae high species representation trees frequently used plant habit leaves formed frequently used plant part decoction infusion using pure water methods preparation suggested administration ranged drinking extracts teaspoonfuls three times daily bathing warm extracts plants use coconut oil cream traditional black soap shea butter also featured herbal remedy bath cream respectively local sponge preferred bathing conclusion study documented alternative medical approach management infantile skin diseases cultural relevance plants calls sustainable use plant resources research finds application primary health care microbiology cosmetic industries development new improved baby skin care products research conducted confirm claimed ethnomedicinal values well evaluate possible harm crude plant extracts skin structures infants
paper deals losses caused welding fix laminated cores traction motor although number studies performed motor design increase motor efficiency technical studies implement effect manufacturing process welding motor design however losses may significant effect motor performances thus paper welding loss models considering flux densities frequencies stack length number welding passes proposed data measured directly welded ring cores finally effect welding loss models verified comparison measured motor losses
paper proposed designed evaluated novel decentralized self learning framework support high reliability energy efficiency periodic traffic applications wsns autonomous framework comprises three main components estimation identification periodic flows dynamic wakeup sleep scheduling asynchronous channel hopping asynchronous channel hopping frequency hopping pattern determined source node autonomously forwarders identify follow pattern also propose light efficient controller eliminate collision caused multi flow overlap forwarders present design evaluation autonomous framework using realistic trace based simulation results show asynchronous channel hopping solution improves packet reception rate compared single channel solutions without need expensive signaling time synchronization overhead also show scheme average energy consumption yields lower single channel solutions furthermore analyze detail energy consumption characteristics autonomous framework operated popular transceiver chipcon texas instruments msp microcontroller analyze much various factors contribute overall energy consumption insights provide valuable guidance start effort geared towards saving energy
anorexia nervosa highly heritable perspective etiology changed behavioral neurobiological neurodevelopmental view however cortical folding important marker deviations brain development yet rarely explored hence order determine potential cortical folding alterations investigated fine grained cortical folding cohort patients patients recovered regarding weight time point mri measurement mri derived cortical folding computed compared patients healthy controls points per hemisphere using surface based technique freesurfer patients exhibited highly significant increased cortical folding right dorsolateral prefrontal cortex region dlpfc furthermore statistical trend direction found right visual cortex find correlation local cortical folding current symptoms disease conclusion analyses provide first evidence altered dlpfc cortical folding plays role etiology absence correlations clinical parameters implicates relatively independence cortical folding alterations current symptomatology might thus regarded trait characteristic disease potentially related neurobiological features
changes chemical microstructural barrier properties two commonly used commercially available waxes microcrystalline wax renaissance wax microcrystalline carnauba blended wax butcher boston polish amber paste wax prevention corrosion outdoor metalwork investigated waxes applied plain patinated substrates bronze steel properties films measured weathering accelerated weathering performed accelerated illumination condensation outdoor weathering standard south florida exposures portland comparison fourier transformed micro infrared nuclear magnetic resonance spectra enabled characterization chemical functional groups waxes weathered showed relative increases methylene character suggestive cross linking appearance terminal vinyl bands suggestive chain scission evidence oxidative film damage annealing microstructural changes observed thin film ray diffraction showed decrease crystallinity indicates decrease barrier properties barrier properties wax films weathering studied electrochemical impedance spectroscopy equivalent electrical circuits provided insights physical state films electrochemical impedance spectroscopy data showed permittivity weathered waxed panels increased observed decrease coating resistance increase coating capacitance photographic documentation substrates showed extensive visible corrosion upon weathering results demonstrate waxed metal panels exposed outdoors period stability protective qualities film change suggests waxes commonly used protect corrosion barrier properties affected flaws microstructure susceptibility chemical alteration weathering results blind study professional conservators participants presented elucidate rank importance factors gloss working lifetime selecting protective coatings
asynchronous tasks programming tasks executed free context main task therefore asynchronous tasks methods implemented non blocking style permitting main method continue running functional programming programming style express hierarchy components computer code style calculations treated similarly treating computations functions mathematics hence memory states modifiable data structures needed functional programming introduced declarative style coding sense expressions replace programs functional object oriented model paper presents accurate type system asynchronous operations job type system stop undefined functions execution hence aborting programs words type system ensures soundness data types hence avoiding static errors like field defined method defined occurring execution time paper introduces well programming example proposed system
paradigm sustainable development largely influenced architecture projects worldwide green building certifications gbcs become new increasingly mandatory standard project performance numerous studies concentrated influence sustainable development final product building however research still needed order understand gbcs influenced building processes particularly collaboration innovation within architecture projects order fill gap study presents results interviews professionals built environment examines three architecture projects conducted canada received widely popular gbc significantly influenced principles design building process research applies recent frameworks exploring stakeholders interests gbcs collaboration innovation practices developed research results show processes within projects shaped least four tensions either enhance hinder collaboration innovation strategic tactical collaborative competitive participative effective individual collective study highlights importance understanding gbc process final outcome thus better manage tensions contribute product process performance
canadian association gastroenterology canadian digestive health foundation published guidelines colon cancer screening subsequent publication guidelines many advances occurred thereby necessitating review existing guidelines context new technologies clinical knowledge assembled guideline panel recognized three recent american sets guidelines identified seven issues required comment canadian perspective issues included among others role program based screening flexible sigmoidoscopy computed tomography colonography barium enema quality improvement panel also provided context selection fecal immunochemical test fecal occult blood test choice relative role colonoscopy primary screening tool recommendations also provided upper age limit colon cancer screening whether upper endoscopy performed following negative colonoscopy positive fecal occult blood test colon cancer screening resume following negative colonoscopy
last several decades wealth illuminating work processes implicated social cognition much less done articulating learn contours particular concepts deployed social cognition like concept mentalistic agent recent developments learning theory afford new tools approaching questions article describe rudimentary ways learning theoretic considerations illuminate philosophically important aspects mentalistic agent concept maintain mentalistic agent essentialized concept gelman essential child keil concepts kinds cognitive development learning theoretic considerations help explain concept tied particular traits
thermal diode fundamental device phononics various mechanisms thermal rectification different temperature dependent thermal conductivity two ends asymmetric interfacial resistance nonlocal behavior phonon transport asymmetric structures phonon hydrodynamics thermomass theory treat heat conduction fluidic viewpoint phonon gas flowing media characterized balance equation momentum like navier stokes equation fluid mechanics generalized heat conduction law thereby contains spatial acceleration convection term viscous laplacian term viscous term predicts size dependent thermal conductivity rectification appears due mfp supersession phonons convection term also predicts rectification inertia effect like gas passing nozzle diffuser
nonreplicating attenuated poxvirus vector nyvac expressing clade hiv env gag pol nef antigens nyvac showed limited immunogenicity phase clinical trials enhance capacity nyvac vector trigger broad humoral responses balanced activation cells compared hiv specific immunogenicity elicited nonhuman primates immunized two replicating nyvac vectors modified insertion vaccinia virus host range genes express clade trimeric hiv protein gag pol nef polyprotein gagderived virus like particles termed nyvac additionally one nyvac vector generated deleting viral gene inhibitor type interferon response nyvac kappa immunization protocol mimicking phase iii clinical trial used two groups macaques received two doses corresponding nyvac vectors weeks booster doses nyvac vectors plus clade hiv protein weeks two replicating nyvac vectors induced enhanced similar hiv specific cell responses similar levels binding igg antibodies low levels iga antibodies high levels antibody dependent cellular cytotoxicity responses hiv neutralizing antibodies small differences within nyvac group seen magnitude cells induction cytokines neutralization hiv isolates thus replication competent nyvac vectors acquired relevant immunological properties vaccine candidates hiv aids viral molecule exerts control immune functions importance special importance find safe effective hiv aids vaccine induce strong broad cell humoral immune responses correlating hiv protection developed novel replicating poxvirus nyvacbased hiv aids vaccine candidates expressing clade hiv antigens one lacking vaccinia virus protein inhibitor type interferon response immunization nonhuman primates novel nyvac vectors protein component elicited high levels cell humoral immune responses vector containing deletion inducing trend toward higher magnitude cell responses neutralization hiv strains poxvirus vectors could considered hiv aids vaccine candidates based activation potential immune correlates protection
memory altered receipt misleading information misinformation effect first studied almost years ago later studies showed suggestive information could even lead creation new false memories people whereas previous research focused primarily false information passively observed events aimed investigate whether memory one physical performance altered means false manipulated replays events virtual reality displayed first person viewpoint explored possibility using misinformation effect beneficially investigating whether affect feeling competence well subsequent sports performance participants took four series shots goalpost soccer field series shown three different types virtual reality replays performance one accurate representation actual performance two manipulated versions one made performance seem worse negative manipulation one made performance seem better positive manipulation participants rated feeling competence replay rated accurately replay displayed real life shots goal manipulated replays considered equally accurate representations actual performance non manipulated ones also type replay manipulation positively correlated feeling competence influence sports performance present study showed memory one physical performance altered means manipulated virtual reality replays used beneficially elsevier inc rights reserved
present study views contraception relationship variable gender study students faculty humanities university magdalena determined article would provide data sexual risk behaviors students useful prevention problem thus descriptive correlational study conducted using purposive sampling participation students findings support conclusion students pose positive reviews increased use condoms pills also negative opinions abstinence intrauterine devices implants hand relationship gender views contraception also opinion students differ according program
power supplies playing significant role different domains engineering applications converters boost buck boost fly back right half plane zero non minimum phase system hence difficult pid controller exhibit good performance load line variations parametric uncertainty proposed work design implementation type controllers performed using factor approach two different optimisation techniques gravitational search algorithm particle swarm optimisation obtaining better stability performance closed loop switched mode boost converter closed loop control system implemented real time dspace platform comparative closed loop performances boost converter classical optimised pid optimised type type iii controllers produced simulations experimental results provided demonstrate effectiveness optimised controllers proposed converter design implementation optimised type controller switch mode converters reported earlier literature
ethnopharmacological relevance dipsacus asper wall clarke effectively traditional chinese medicine treating osteoporosis bone fracture studies pharmacological mechanism mostly centered cell gene level little known metabolic signatures aim study investigate anti osteoporosis effects crude wine processed global untargeted metabolic profiling rats serum liver kidney derived sham model treated groups method total female wistar rats divided five groups sham group model group crude wine processed treated group treatment rats orally administered beta estradiol crude wine processed extract therapeutic dose daily throughout experimental period sham group model group orally gavaged approximately volume saline solution weeks serum liver kidney samples five groups collected metabolomic alterations monitored gas chromatography mass spectrometry resulting dataset analyzed principal component analysis pca partial least squares discriminant analysis pis identification potential biomarkers performed using reference standard nist library moreover clinical chemistry biomechanical analysis also performed ensure success osteoporosis model validate anti osteoporosis effect crude wine processed results clear separation trend among sham model treatment group observed pca score plot anti osteoporosis effect wine processed indicated pls score plots total metabolite biomarkers identified wine processed treated groups respectively pathway analysis revealed phenylalanine tyrosine tryptophan biosynthesis valine leucine isoleucine biosynthesis methane metabolism glycine serine threonine metabolism galactose metabolism major intervened pathways compared model group levels biomarkers gradually restored normal administration wine processed conclusion anti osteoporosis effect wine processed reliably confirmed metabolomics approach osteoporosis might prevented wine processed via intervening amino acid metabolism carbohydrate metabolism energy metabolism vivo rats
paper presents high voltage integrated circuit driver capable producing analog voltages using dalsa cmos dmos process suitable mems medical systems driver includes operational amplifier amp class output stage analog switches improved isolation performance contrast previous frequency compensation schemes one dominant pole occurs unity gain bandwidth amp employs novel frequency compensation topology three poles two zeros located within unity gain bandwidth capable driving large capacitive loads theoretical analysis isolation analog switches also reported confirms improvement isolation performance
paper deals technique simulation higher order electrical circuits parameters varying randomly principle consists utilization theory stochastic differential equations sde namely vector form ordinary sdes random changes excitation voltage parameters passive circuit elements considered circuit responses analyzed voltage current responses computed represented form sample means accompanied confidence intervals provide reliable estimates method applied analyze responses circuit models optional orders specially consisting cascade connection rlgc networks develop model equations state variable method used afterwards corresponding vector sde formulated stochastic euler numerical method applied verify results deterministic responses also computed help pspice simulator numerical inverse laplace transforms nilt procedure matlab removing random terms circuit model
linear convolution scheme involving first order linear kernels linear bridge aerodynamics first reviewed significance selection proper input parameters emphasized following concept nonlinear indicial response function linear convolution scheme extended nonlinear convolution scheme involving higher order nonlinear kernels treatment nonlinear bridge aerodynamics using peeling onion type procedure utilizing impulse function input comprehensive kernel identification scheme developed numerical example long span suspension bridge investigated verify fidelity proposed nonlinear convolution scheme elsevier ltd rights reserved
study examined risk boys social self efficacy physical activity self efficacy within bandura self efficacy framework total boys aged years attending summer sports camp completed questionnaires assessing social self efficacy physical activity self efficacy prosocial behaviors effort results indicated social self efficacy physical activity self efficacy clearly distinguishable however two constructs strong positive correlation social self efficacy physical activity self efficacy predicted prosocial behaviors significantly social self efficacy stronger predictive power physical activity self efficacy better predictor effort social self efficacy study provides initial empirical evidence supporting bandura conceptualization domain specific features predictive power self efficacy summer sports camp setting thus enables better understanding nature effects self efficacy
lamotrigine ltg antiepileptic drug metabolized via glucuronidation since glucuronidizing enzyme inducible estrogens ltg serum concentrations may fall combined hormonal contraceptives contain ethinyl estradiol little known possible interaction estrogens used hormone replacement therapy hrt ltg available data conflicting data serum samples analyzed ltg therefore retrieved routine therapeutic drug monitoring database users hrt identified matched controls age dose enzyme inducing enzyme inhibiting comedication allowed ltg serum concentration dose ratios cdrs calculated case groups respective control groups compared mann whitney test seventy nine hrt users dose range day users dose range day well matching controls respectively could included users hrt users significantly lower mean ltg cdrs respective matched controls results suggest hrt estrogens may reduce serum ltg concentrations
describe implementations nonadaptive beamforming problems interesting solved fast using general purpose processors field programmable gate arrays xpu configurable massively parallel data flow architecture based automatic data flow synchronization designed data task level parallelism briefly introduce prototype device summarize recent architectural changes emphasize practical programnung aspects particular consider problem often overlooked frequently literature algorithm presented fast solves part problem
rapid development urban areas due population infrastructure growth led increased traffic congestion greater demand residential space environmental issues one solution problems development underground space especially tunnelling however tunnel collapse causes significant damage important understand interactive behaviour soil structure tunnelling urban areas study uses model test investigate behaviour embedded pile surrounding ground due tunnelling soft ground tunnelling simulated volume loss soil deformation observed according using close range photogrammetry image processing data compared numerical analysis
aim special section paper contributes review current trends borderline personality disorder bpd research three major trends identified first marked increase studies attempt locate bpd dimensional latent structure psychopathology second identifying endophenotypic markers associated bpd become focus interest focus one endophenotype form impaired self processing third explosion research developmental aspects bpd specifically focused uncovering complex biology environment interactions development bpd paper discusses trends dimensions biology development challenging nature form bpd know may indicative broader sea change psychiatric nosology
underlying theories control engineering real time systems engineering assume idealized system abstractions mutually neglect central aspects discipline control engineering theory one hand usually assumes jitter free sampling constant input output latencies disregarding complex real world timing effects real time engineering theory hand uses abstract performance models neglect functional behavior derives worst case situations little expressiveness control functionalities physically dominated automotive systems consequence lot potential systematic engineering disciplines increasing design efficiency confidence paper discuss possible approaches engineering current applicability real world problems particular compare simulation based formal verification techniques various construction principles automotive real time control software
aims several alternative cellular approaches using biomaterials host insulin producing cells derived stem cells developed overcome limitations type diabetes treatment exogenous insulin injection however none seem fulfill requirements needed induce pancreatic cells successful colonization scaffolds report polymeric platform adherent native mice pancreas filled human adipose stem cells hascs able induce growth pancreatic parenchyma main methods synthetic polyether polyurethane discs placed adjacent pancreas normoglycemic streptozotocin induced diabetic mice day post implantation hascs injected intra implant groups normoglycemic diabetic mice immunohistochemistry analysis implants performed identify insulin positive cells newly formed tissue addition metabolic inflammatory angiogenic parameters carried mice key findings study provides evidence ability biohybrid device induce growth differentiated pancreas parenchyma normoglycemic streptozotocin induced diabetic mice detected histological analysis glucose metabolism body weight hyperglycemic mice bearing hascs implants improved significance synthetic porous scaffold bearing hasc cells placed adjacent native animal pancreas exhibits potential exploited future cell based type diabetes therapies elsevier inc rights reserved
objective spondyloarthritis spa often diagnosed late course disease improved methods early diagnosis required tested ability genetic profiling diagnose axial spa axspa whole group ankylosing spondylitis alone cohort chronic back pain patients methods patients recruited centres united kingdom germany taiwan canada columbia turkey part asas classification criteria axspa study asas cohort subjects classified according asas axspa criteria modified new york criteria patients genotyped similar immune mediated disease snps using illumina immunochip results first established predictive accuracy genetic data comparing healthy controls cases homogenous international genetics igas consortium immunochip study showed excellent predictive power auc genetic risk scores lower predictive power auc comparing asas cohort axspa cases meeting asas imaging criteria igas controls comparing genetic risk scores showed moderate discriminatory capacity igas asas imaging positive cases auc indicating significant differences genetic makeup exist cohorts conclusion clinical setting referred back pain patients suspected axial spa unable use genetic data construct predictive model better based existing clinical data potential confounding factors include significant heterogeneity asas cohort possibly reflecting disease heterogeneity axspa differences centres ascertainment classification performance
software development process developers often seek solutions technical problems encounter searching relevant questions sites developers fail find solutions sites native language chinese could translate query search sites another language english however developers non native english speakers often comfortable ask search questions english know proper translation chinese technical words english technical words furthermore process manually formulating cross language queries determining weight query words tedious time consuming process purpose helping chinese developers take advantage rich knowledge base english version stack overflow simplify retrieval process propose automated cross language relevant question retrieval clrqr system retrieve relevant english questions stack overflow given chinese question clrqr system first extracts essential information chinese english title description input chinese question performs domain specific translation essential chinese information english formulates query highest scored english words retrieving relevant questions repository java questions english stack overflow evaluate performance proposed approach also propose four online retrieval approaches baselines randomly select java questions segmentfault vex two chinese websites computer programming query chinese questions approach returns top relevant questions given chinese question invite users evaluate relevance retrieved english questions experiment results show clrqr system outperforms four baseline approaches statistical tests show improvements significant
large aperture composite adaptive optics laser applications investigated cooperation institute plasma physic department instrumentation control engineering fme ctu ltd exploring opportunity large size high power laser deformable mirror production using lightweight bimorph actuated structure composite core order produce sufficiently large operational free aperture developing new technologies production flexible core bimorph actuator deformable mirror reflector full simulation deformable mirrors structure prepared validated complex testing deformable mirror actuation response complicated structure investigated accurate control adaptive optics original adaptive optics control system bimorph deformable mirror driver developed tests material samples components sub assemblies completed subscale bimorph deformable mirror prototype designed fabricated thoroughly tested large size composite core bimorph deformable mirror simulated optimized fabrication prototype carried measurement testing facility modified accommodate large sizes optics
although pain one commonly experienced symptoms patients chronic kidney disease recognized severity underestimated treatment inadequate pain management one general primary palliative care competencies medical providers review provides nephrology prokr iders basic skills pain management skills include recognition types pain nociceptive neuropathic syndromes appropriate history taking skills history providers identify clinical circumstances specialist referral beneficial including high risk addiction risk adverse effects medications complicated care needs patients limited prognosis management pain begins development shared treatment plan identification appropriate medications continual follow assessment efficacy adverse effects adequate pain management providers positively affect health individual patients performance health care systems national kidney foundation inc published elsevier inc rights reserved
human respiratory syncytial virus group rsv detected symptomatic hospital attended children central spain continuous time period september april order accurately describe epidemiology virus genetic diversity complete gene clinical manifestations observed jointly analyzed respiratory specimens taken children positive rsv rsv complete gene sequences randomly selected rsv virus identified genotypes emerged sporadically become dominant cases sequences contained duplication clinical diagnosis children genotype bronchiolitis recurrent wheezing asthma exacerbations laryngotracheobronchitis upper respiratory tract infections eight results showed replacement substitution circulating genotype new genotype nevertheless stage none rsv genotypes identified resulted significant clinical differences amino acid composition complete gene sequences demonstrated accumulation single changes related different clinical presentation wiley periodicals inc
background medicare beneficiaries receiving cardiac resynchronization therapy defibrillators crt wide qrs complex duration qrsd outcomes crt patients well established underrepresented clinical trials objectives study examined outcomes patients crt wide qrsd left bundle branch block lbbb versus without lbbb methods medicare patients implantable cardioverter defibrillator registry january april crt confirmed class iia indications crt matched implantable cardioverter defibrillator icd patients without crt despite class iia indications crt mortality heart failure hospitalizations longer years crt versus standard icds based qrsd morphology analyzed results analyzed patients among lbbb patients qrsd greater adjusted survival benefit crt versus standard icd hazard ration death confidence interval compared qrsd crt versus icd associated improvement survival lbbb qrsd adjusted death lbbb qrsd adjusted death conclusions improvements survival heart failure hospitalizations crt greatest patients qrsd without lbbb whereas patients qrsd without lbbb improvement survival crt qrsd lbbb modest improvement published elsevier behalf american college cardiology foundation
adequate elimination diet recommended mainstay food allergy management patients food allergies treated dietician specialized allergies long term elimination diet patients receive information regarding allergy labeling according food information regulations learn possible pitfalls system essential foods deleted menu due allergic reactions must replaced suitable equivalent foods allergic patients provoked regularly intervals order determine whether patient outgrown allergy new allergies emerged
introduction role testosterone supplementation treatment male sexual dysfunction remains questionable aim aim study attempt meta analysis effect male sexual function synergism use phosphodiesterase type inhibitor pdei methods extensive medline embase cochrane search performed main outcome measures randomized controlled trials rcts comparing effect placebo effect add pdeis sexual function included data extraction performed independently two authors isidori corona conflicts resolved third investigator maggi results retrieved articles included study particular compared placebo whereas trials evaluated effect add pdeis able significantly ameliorate erectile function improve aspects male sexual response hypogonadal patients however presence possible publication bias detected applying trim fill method positive effect erectile function libido components retained significance rcts partially completely supported pharmaceutical companies confidence interval respectively addition also report could associated improvement pdei outcome results confirmed placebo controlled studies majority studies however included mixed eugonadal hypogonadal subjects thus imparting uncertainty statistical analyses conclusions plays positive effects male sexual function hypogonadal subjects role uncertain men clearly hypogonadal apparent difference industry supported independent studies could depend trial design publication bias new rcts exploring effect selected cases pdei failure persistently retain low testosterone levels advisable corona isidori buvat aversa rastrelli hackett rochira sforza lenzi mannucci maggi testosterone supplementation sexual function meta analysis study sex med
surface roughness wettability among surface properties determine service lifetime materials mechanical treatments subjected surface layer materials often performed obtain desired surface properties enhance mechanical strength materials paper surface microhardness roughness wettability aisi stainless steel resulting surface mechanical attrition treatment smat discussed smat conducted various processing parameters including duration treatment number diameter milling ball motor speed smat machine result indicates increasing surface microhardness due smat harder surface yielded smat longer duration bigger larger number milling balls higher vibration frequency smat also creates craters steel surfaces correspond increasing roughness values ranging change surface roughness smat depend duration treatment also processing parameters addition wettability aisi surface slightly increases smat seen decreasing droplet contact angle degrees values ranging degrees degrees droplet contact angle reduction related increasing surface roughness smat conclusion study reveals possibility smat used surface properties optimization addition strength enhancement stainless steel elsevier rights reserved
september terrorist attack occurred research psychiatric outcomes focused individual disorders rather broader internalizing int externalizing ext domains psychopathology leaving unknown whether direct indirect exposure differentially impacted domains rather individual disorders whether effects exacerbated earlier childhood maltreatment stress sensitization unknown participants national sample history psychiatric disorders prior assessed using structured person interview structural equation modeling conducted sample endorsed psychiatric history prior indicated indirect exposure media friends family related ext alcohol nicotine cannabis dependence antisocial personality disorder int major depression generalized anxiety post traumatic stress disorder ptsd dimensions psychopathology ext beta int beta whereas direct exposure associated int dimension beta individuals experienced childhood maltreatment risk ext int dimensions associated exacerbated interactions beta beta respectively findings indicate impacted latent liability broad domains psychopathology general population rather specific disorders exception ptsd independent effects beyond int indicated significant improvement modification indices findings also indicated childhood maltreatment increases risk associated adult trauma exposure providing evidence concept stress sensitization published elsevier ltd
reduce fuel consumption internal combustion engines attention paid tribological performance piston ring pack cold start idle operations research numerical model considering cylinder liner deformation piston ring conformability developed predict blow lubrication friction wear piston ring pack different operating conditions gas flow rate inter ring gas pressures minimum oil film thickness frictional force wear load cold start calculated compared warm idle operating conditions results show cylinder liner deformation piston ring conformability together obviously affect blow tribological performance meanwhile found friction loss larger cold start warm idle operating conditions however wear process severe warm idle operation cold start research blow tribological performance piston ring pack cold start warm idle operations understood deeply
research underwater acoustics seen major development past decade due widespread applications domains underwater communication navigation sonar seismic exploration oceanography particular acoustic signatures partially fully buried targets used identification buried mines mine counter measures mcm although exist several techniques identify target properties based sonar images acoustic signatures methods first employ feature extraction method represent dominant characteristics data set followed use appropriate classifier based neural networks relevance vector machine aim present study demonstrate applications proper orthogonal decomposition pod technique capturing dominant features set scattered pressure signals subsequent use pod modes coefficients identification partially buried underwater target parameters location size material density several numerical examples presented demonstrate performance system identification method based pod although present study based acoustic model method easily extended models thereby enables cost effective representations large scale data elsevier ltd rights reserved
manufacture low density paper tissue towel utilizes creping process consists adhesively bonding paper wet state onto surface smooth drying cylinder scraping blade dried paper mechanics materials description creping process presented based upon previous experimental observations mechanism creping process proposed periodic debonding strength materials failure criterion applied buckling sequence elastic thin film numerical calculations show results consistent experimental data known industrial observations crepe wavelength versus creping angle data experiments satisfactorily reproduced reasonable set values input parameters model parametric study shows adhesive shear strength sheet stiffness significantly affect crepe wavelength creping force model provides guidance understanding optimizing creping process produce high quality products doi
objective obesity associated hypogonadism hypothesized due suppressive effect high estradiol increase aromatase activity present abundant adipose tissue hypothalamic pituitary gonadal unit resulting low testosterone production although weight loss found effective reducing estradiol raising testosterone levels studies younger men effect frail obese older men understudied thus objective study determine effect lifestyle intervention hormone levels frail obese older men design randomized controlled trial lifestyle intervention frail obese older men year setting university hospital methods forty frail obese elderly men randomized week study following treatment groups control group diet induced weight loss group diet group exercise training group exercise group diet induced weight loss exercise training group diet exercise group objective achieve similar weight loss months maintain weight additional months physical function assessed modified physical performance testing modified ppt estradiol measured radioimmunoassay testosterone automated immunoassay sex hormone binding globulin enzyme linked immunoassay results months intervention diet alone resulted weight loss diet group diet exercise group resulted significant decrease total estradiol compared baseline among subjects diet diet exercise group free estradiol index also significantly decreased diet pmol nmol diet exercise pmol nmol group total testosterone significantly increased response diet diet exercise resulting values diet diet exercise group however significant increase sex hormonebinding globulin levels diet diet exercise groups free testosterone index changes free testosterone index significant compared baseline regardless changes hormonal levels patients diet exercise diet exercise groups experienced significant improvements modified ppt baseline conclusion weight loss lifestyle intervention resulted significant decreases total free estradiol levels frail obese older men result clinically important increase total testosterone significant increase free testosterone thus alternative forms treatment addition lifestyle intervention may necessary improve hormonal profile among patients nevertheless whether improvement hormonal profile would result better physical performance achieved lifestyle alone subjects remains uncertain
purpose two types bradykinin mediated angioedema hereditary angioedema hae acquired angioedema aae result deficiency dysfunction esterase inhibitor leading overproduction bradykinin lead vascular permeability life threatening angioedema airway objective study review perioperative outcomes series patients hae aae review current knowledge anesthetic complications patients hae aae methods medical records retrospectively reviewed perioperative complications patients hae aae underwent general anesthesia january december institution results twenty four patients hae aae unspecified angioedema underwent instances general anesthesia airway manipulation except received prophylactic therapy one patient year old woman pretreated stanozolol fresh frozen plasma required reintubation postoperative airway edema developed conclusion life threatening episodes angioedema airway occur infrequently occur patients received pretreatment patients previously undergone anesthesia uneventfully anesthesiologists must ready emergently manage difficult airway must familiar recommendations provided consensus guidelines treatment hae aae patients elsevier inc rights reserved
purpose goal study scrutinize psychological processes occur individuals developing identification highly diverse team design methodology approach qualitative theory generating approach following principles grounded theory chosen research design data obtained personal interviews members seven peacebuilding teams liberia haiti teams particularly well suited analyzing dynamics identification processes constitute extreme cases respect team members identity diversity findings analysis reveals four different processes occur individuals develop team identification enacting salient identity sensemaking team experience evaluating collective team outcomes converging identity implications show team members engage individual collective directed sensemaking processes development thereby using internal team members external points reference team external actors ingroup outgroup comparisons moreover study reveals different modes identity convergence active reactive withdrawal associated different types deep structured situated disidentification originality value although team members identification workgroup long considered important effective team functioning knowledge development remained limited largely without empirical footing real world team context study represents first empirical attempt inductively identify processes occur individuals develop
paper second order sliding mode sosm control approach applied synchronous buck converters proposed sosm controller stabilize synchronous buck converters using simple digital state machine structure without requiring current sensing integral term control loop sosm controller results fast step load start transient responses robust parameter uncertainties fast transients current limitation start accomplished adjusting one controller parameter furthermore hysteresis method introduced control switching frequency proposed approach verified experimental results prototype
objectified body consciousness obc appears play crucial role eating body related disturbances typically emerge adolescence item obc scale obcs employed eating disorder research school based adolescent samples evidence psychometric proprieties exists adult nonclinical populations evaluated construct validity reliability item obcs data collected adolescent girls boys community study adolescents genders study whether instrument functions similarly equivalently measures underlying construct across gender samples test measurement equivalence invariance study results upheld three factor structure measurement equivalence invariance item obcs across gender samples obcs subscale scores internally consistent stable week period obcs subscales discriminated community participants high low symptom levels fair accuracy well community participants also associated five constructs closely related obc psychopathology latent mean comparisons across samples gender performed discussed implications directions future research also outlined
phthalates considered dangerous priority pollutants several effects attributed foetal deformations cancers endocrine disruptions activated carbons highly efficient materials adsorption numerous organic molecules use important first determine textural chemical properties study kinetics thermodynamics adsorption understand optimize interactions material molecules aim work study kinetics adsorption isotherms three phthalates dimethylphthalate diethylphthalate diethylhexylphthalate currently found industrial effluents two different activated carbons adsorption molecules synthetic mix complex matrices modeled kinetic study adsorption isotherms dimethylphthalate diethylphthalate monosolute bisolute first investigated followed similar study mix three molecules complex matrices surface water loire loiret rivers near orleans city municipal wastewater treatment plant outflow pseudo second order kinetic model used determine kinetic adsorption parameters langmuir equation used calculate surface occupied results showed non electrostatic interactions predominant phthalate adsorption complex matrices mainly due dispersion forces hydrophobic interactions
nonlinear dynamic model passively cooled small modular reactor smr developed nuclear steam supply system nsss model includes representations reactor core steam generator pressurizer hot leg riser downcomers reactor core modeled combination neutronics thermal hydraulics helical coil steam generator single tube depiction time varying boundaries three regions subcooled boiling superheated adopted pressurizer model developed based upon conservation fluid mass volume energy hot leg riser downcomers treated first order lags finally nsss model incorporated turbine model permits observing mechanical power overall nonlinear system simulated typical perturbations control rod withdrawal increase steam demand detailed analysis results show steady state values full power good agreement design data model capable predicting dynamics smr elsevier ltd rights reserved
emerging world human robot interaction people robots work together achieve joint objectives paper discusses design validation general scheme creating emotionally expressive behaviours robots order people might better interpret robot collaborator succeeding failing work exemplifies unified approach creating robot behaviours two different robot forms based combinations four groups design parameters approach avoidance energy intensity frequency people rated video clips robots performing expressive behaviours emotional expressivity valence arousal dominance dimensions judgement successfulness robots work results discussed terms utility expressive behaviour facilitating human understanding robot intentions design cues basic emotional states
life cycle assessment lca prominent technique assessment environmental impacts products typically operates basis average meteorological ecological conditions whole countries large regions limits representativeness accuracy lca particularly field agriculture production processes associated agricultural commodities characterized high spatial sensitivity inputs mineral organic fertilizers accompanying release emissions soil air water nitrate dinitrogen monoxide phosphate emissions largely determined micro spatial environmental parameters precipitation soil properties slope etc therefore highly context dependent spatial variability vastly ignored unit world assumption inherent lca paper present new calculation framework regionalized life cycle inventory modeling aims overcome inherent limitation framework allows automated site specific generation assessment regionalized unit process datasets demonstrate framework case study rapeseed cultivation germany results research framework generating regionalized data structures first examination significance use cases
previous research demonstrated participants remember significantly survival related information information processed survival relevance recent research also shown survival materials processing result false memories ones adaptive inasmuch prime solutions insight based problems importantly false memories survival related information facilitate problem solving false memories types information present study explores survival advantage using incidental rather intentional memory task participants rated information either context importance survival processing scenario moving new house following participants solved number compound remote associate tasks crats half solution primed false memories generated processing task results showed crats primed false memories incidental task participants solving significantly crats primed unprimed effect greatest participants rated items survival moving processing items survival scenario improved overall problem solving performance even specific problems primed results discussed regard adaptive theories memory
present study investigates relationship violent false memories delinquent aggressive behavior sample adolescents two hundred eleven participants completed measures aggressive delinquent behavior performed modified version deese roediger mcdermott drm paradigm false memory task lists associated words participants presented list ambiguously violent words three lists neutral words list free recall task performed violent false memories significantly associated delinquent behaviors genders whereas significant correlation aggressive behaviors found males multilevel multiple regression showed prediction delinquent behaviors improved entering violent false memories model predictor whereas effect found aggressive behaviors findings indicate significant association violent false memories delinquent behavior adolescents foundation professionals services adolescents published elsevier ltd rights reserved
genetic loci associated risk alzheimer disease reported genome wide significant loci account estimated heritability provide little information underlying biological mechanisms genetic studies using intermediate quantitative traits biomarkers endophenotypes benefit increased statistical power identify variants may pass stringent multiple test correction case control studies endophenotypes also contain additional information helpful identifying variants genes associated aspects disease rate progression onset provide context interpret results genome wide association studies gwas conducted gwas amyloid beta beta tau phosphorylated tau ptau levels cerebrospinal fluid csf participants across nine studies identify novel variants associated five genome wide significant loci two novel associated ptau including loci also associated risk brain related phenotypes two novel loci associated beta near glis beta within serpinb beta also associated risk glis disease progression glis beta age onset ser pinb beta bioinformatics indicate intronic serpinb variant affects expression serpinb various tissues including hippocampus suggesting serpinb influences beta associated mechanism analyses known risk loci suggest clu fermt may influence csf beta respectively inppd locus may affect ptau levels larger studies necessary verify results together findings study used inform future studies
experiment tested whether young children able reduce false recognition rate distinctive encoding implementing strategic metacognitive rule participants children aged years studied two lists unrelated items one lists visually displayed picture condition whereas presented auditorily word condition study phase participants completed recognition tests finally answered questions explicit knowledge distinctive encoding effect results revealed even youngest children sample showed smaller proportion intrusions picture condition word condition furthermore results signal detection analyses consistent hypothesis lower rate false recognitions picture encoding results implementation conservative response criterion based metacognitive expectations distinctiveness heuristic moreover absence correlation children explicit knowledge distinctiveness rule effective use metacognitive heuristic seems indicate involvement memory decisions could mediated implicit mechanisms elsevier inc rights reserved
two studies examined development constructivist theory mind tom late childhood early adolescence study new measure developed assess participants understanding interpretive constructive processes embedded memory comprehension attention comparison planning inference using measure study tested mediational model prosocial reasoning conflict mediated relation constructivist tom behavior problems high school results showed onset constructivist tom occurs late childhood early adolescence adolescents advanced constructivist tom prosocial reasoning conflict turn mediated relation fewer serious behavior problems high school controlling academic performance sex studies girls showed advanced constructivist tom boys high school elsevier inc rights reserved
aim paper present superior transient response digital peak current mode converter order address input voltage fluctuation power feeding system quick response important load fluctuation also input voltage fluctuation since proposed peak current mode control method detect peak current real time transient response improve compared conventional digital voltage mode pid control result convergence time undershoot output voltage suppressed
osteoarthritis chronic progressive disease complicated mechanisms involve inflammation cartilage degradation study investigated anti inflammatory action salvianolic acid sal human chondrocytes mouse model induced destabilization medial meniscus vitro chondrocytes pretreated sal incubated beta production determined griess method pge assessed elisa expression inos cox mmp adamts kappa related signaling molecules tested western blotting immunofluorescence staining used detect nuclear translocation vivo mouse model received intraperitoneal injection either sal saline every day hematoxylin eosin well safranin fast green staining utilized evaluate severity cartilage lesions weeks following surgery sal inhibited production pge elevated expression inos cox mmp adamts reversed sal beta induced chondrocytes addition beta significantly induced phosphorylation kappa signaling phosphorylation response blocked sal immunofluorescence staining demonstrated sal could suppress beta induced nuclear translocation vivo cartilage sal treated mice exhibited less cartilage degradation lower oarsi scores taken together sal possesses great potential value therapeutic agent treatment published elsevier
heterogeneous photocatalysis suitable add process conventional wastewater treatment methods aiming full degradation emerging contaminants contributing water pollution work examines photo degradation two frequently detected emerging contaminants caffeine salicylic acid using titanium dioxide nanotubular films tnts commercial tio nanoparticulate films evonik comparison tnt films prepared electrochemical anodization titanium metal reached lengths high growth rate present open porous structure large specific surface area suitable efficient adsorption contaminants formation large number photocatalytic active sites calcination degrees tnt films obtain anatase crystal structure absorb well range present significant photocatalytic activity high degradation rates examined emerging pollutants furthermore present small variability photocatalytic efficiency big range solutions values consecutive photocatalytic cycles rendering suitable various wastewater treatment conditions elsevier rights reserved
laser based additive manufacturing attracted much attention promising printing method metallic components recent years however surface roughness additive manufactured components considered challenge achieve high performance work demonstrate capability fiber laser polishing rough surface additive manufactured based alloys received surface laser polished surfaces well cross section subsurfaces analyzed carefully white light interference confocal microscope focus ion beam scanning electron microscopy energy dispersive spectrometer ray diffraction results revealed received based alloys surface roughness ism could reduce less laser polishing process moreover microstructure microhardness wear resistance laser polished zone investigated order examine thermal effect laser polishing processing substrate additive manufactured alloys proof concept process potential effectively improve surface roughness additive manufactured metallic alloy local polishing method without damage substrate
background poor sleep frequent complaint persons hiv infection objectives pilot test tailored sleep promotion intervention protocol based principles sleep hygiene convenience sample hiv seropositive women methods baseline week implementing intervention sleep assessed self reports measures wrist actigraphy objective sleep measures include total sleep time number awakenings sleep efficiency well level daytime activity activity rhythm amount sleep day results prior intervention women averaged sleep sample napped min per day allowing week implement sleep hygiene principles promote healthy sleep behaviors significant improvement perception sleep significant change activity rhythm involved activity less napping day discussion although minimal change objective measures nighttime sleep group whole initiation insomnia maintenance insomnia benefited intervention findings support utility tailored sleep promotion intervention women hiv positive address unique form sleep disturbance
aimed test relationships trust god positive negative affect feelings hope sample university students female completed positive negative affect schedule adult dispositional hope scale persian measure trust god muslims results series hierarchical regression analyses indicated trust god positively associated participants scores hope positive affect negatively associated scores negative affect results support relationship trust god indices mental health
children doodle way graffiti completely unconscious might want show emotions graffiti result high degree attention children graffiti appreciation education stimulate potential also promote growth children health happiness article mainly feelings chinese father passport doodled son children graffiti without awareness using appreciation education appreciate understand accept child results properly correctly guide children early paintings
paper deals dimensional nonlinear evolution equation nlee generated jaulent miodek hierarchy nonlinear water waves via hirota bilinear method pfaffian first construct rational solutions general bilinear equations convert target bilinear equations general ones obtain rational solutions pfaffian plays role simplifying computations compared determinant way existing literatures first second order rational solutions obtained higher order solutions derived token figures first second order rational solutions plotted analyzed application rational solutions modified kadomtsev petviashvili equation also constructed method might used nlees construct rational solutions elsevier ltd rights reserved
opioid induced androgen deficiency opiad initially recognized possible consequence opioid use roughly four decades ago long acting opioid use carries risks addiction tolerance systemic side effects including hypogonadotropic hypogonadism consequent testosterone depletion leading multiple central peripheral effects hypogonadism induced direct inhibitory action opioids receptors within hypothalamic pituitary gonadal hpg hypothalamic pituitary adrenal hpa axes well testosterone production within testes studies systematically investigated hormonal changes induced long term opioid administration effects testosterone replacement therapy trt patients opiad clomiphene citrate selective estrogen receptor modulator serm testosterone enhancement treatment upregulates endogenous hypothalamic function review focus pathophysiology diagnosis management opiad including summary literature evaluating opiad treatment trt areas future investigation
study proposes home assembled low cost blue light emitting diode led photometer uses simple low cost hardware software costing wavelength photometer controlled microcontroller chip glucose concentration detection experiments involving enzyme coupling reactions carried verify performance proposed system measurement errors system improved less proposed led photometer used students electronics classes conduct biotechnological tests part electrical electronics vocational high school education help explore basic applications biosensors enhance professional abilities executing fundamental bioelectronics processes pretest post test assessments students knowledge bioelectronics conducted determine efficacy proposed system enhancing students knowledge led photometer modified test various samples biochemistry analytical chemistry also applied various fields electronics chemical engineering biochemistry
paper aim draws together two ideas figured different strands discussion business ethics ideas intuition reflection considered company third complementary idea analysis argued interplay amongst important business ethics relationship amongst three ideas understood reference parts modern cognitive psychology including dual process theory social intuitionist model intuition misleading based fast frugal heuristics reasoning needs social exchange support moral judgment effectively complex institutional environment business reflection analysis underpin social communication feedback develop sound intuition reflection analysis deliberate systematic judgment processes intuition distinguished fact reflection embraces hypothetical thinking imagination analysis careful step step reasoning examples business ethics problems illustrate need processes also suggest enhanced social exchange process underpins development good intuition
purpose present study examine whether repeated exposure cyberbullying bystander impact early adolescents moral evaluations terms decrease empathy shift towards tolerant attitude towards cyberbullying two wave panel study month time interval conducted among sample adolescents aged cross lagged panel analysis used investigate relationships time bystander cyberbullying empathic responsiveness towards distressed others attitude towards cyberbullying taking account involvement cyberbullying victim perpetrator results indicate negative relationship standing time empathic responsiveness time words exposure cyberbullying bystander time predicted subsequent lower levels empathic responsiveness time attitude towards cyberbullying time influenced seeing cyberbullying acts time implications results prevention intervention future research discussed elsevier ltd rights reserved
paper present cmos implementation cell associative content addressable memory acam cmos memory operated either associative cam configured willshaw memory operating sparse data vector matching operation use tunable hit threshold strongest hit selected winner take wta network built row column circuitry perform logic operations contents row column memories operation circuit verified experimentally example computing random vectors
background congenital heart disease chd common birth defect cases occur sporadically mutations key genes responsible cardiac development could contribute chd date genetic causes chd remain largely unknown methods study twenty nine candidate genes chd sequenced patients tetralogy fallot tof using target exome sequencing tes immunoprecipitation luciferase reporter gene assays performed hekt cells wild type mutant mrna zfpm microinjected zebrafish embryos results rare variants key cardiac transcriptional factors jag identified patients four patients carried multiple gene variants novel variant located eighth zinc finger domain fog protein assays hekt cells revealed variant significantly damaged interaction zfpm fog gata luciferase reporter gene assays revealed mutant zfpm protein displayed significantly greater inhibition transcriptional activation gata wild type protein wildtype mrna mutant mrna zfpm injected zebrafish embryos hpf mutant mrna injection group number embryos abnormal cardiac chamber structure loss left right asymmetry increased hpf defects chamber left right asymmetry became obvious conclusions performed tes sporadic tof patients identified rare variants candidate genes chd first validated variant zfpm likely involved pathogenesis chd via gata moreover results suggest tes could useful tool discovering sequence variants chd patients
known machine design time consuming complicated process consequently verification designs machine performances known optimization methods prior fabrication becoming complex expensive relating issue many studies achieved realize optimization analyze dynamic performance designed machines paper optimization short open circuit fault analysis along transient performance designed radial flux permanent magnet synchronous generator rfpmsg stand alone wind turbine studied main feature study use rmxprt dynamic generator model linked ansys simplorer external circuit simulator simulation method used analyze performance generator considered feeding ohmic load method also yields waveforms load voltages load currents different load wind speed conditions along experimental studies hydrogen energy publications llc published elsevier ltd rights reserved
focus paper develop semi parallel control method using inversion identification model magnetorheological fluid damper along smart predictor controller spc damping system using damper electrohydraulic actuator eha order realize real time position force control industrial task requiring interaction environment inverse model fluid damper established base self tuning lyapunov based fuzzy stlf model stlf model designed form center average fuzzy interference system fuzzy rules planted based lyapunov stability condition addition order optimize stlf model back propagation learning rules used adjust fuzzy weighting net meanwhile spc constructed using nonlinear pid controller npid base feedforward neural network smart grey markov predictor sgmp npid controller built drive system desired targets additionally learning mechanism robust checking conditions implemented npid order optimize online parameters respect control error minimization besides sgmp self tuning ability predictor step size takes part first estimating system
volume rendering relevant topic scientific visualization last decades however exploration reasonably big volume datasets requires considerable computing power limited field desktop scenario recent advances mobile graphics hardware motivated research community overcome restrictions bring volume graphics ubiquitous handheld platforms survey presents past present work mobile volume rendering meant serve overview introduction field proposes classification current efforts covers aspects advantages issues mobile platforms rendering strategies performance user interfaces paper ends highlighting promising research directions motivate development new interesting mobile volume solutions
point vortex models frequently encountered conceptual studies geophysical fluid dynamics also practical applications instance aeronautics spherical geometry motion vortex centres governed dynamical system known poisson structure construct poisson integration methods dynamics splitting hamiltonian constituent vortex pair terms backward error analysis method formally known provide solutions modified poisson system correct bracket modified hamiltonian function different orderings pair wise interactions considered also used construction higher order methods energy momentum conservation splitting schemes demonstrated several test cases particular orderings pairwise interactions schemes allow scalable parallelization results linear opposed quadratic scaling computation time system size scaling number processors accordingly elsevier rights reserved
solar tower technology promising way generate sustainable electricity concentrated solar radiation one effective variants technology called volumetric air receiver used convert concentrated radiation heat component consists high temperature resistant cellular material absorbs radiation transfers heat air flow fed ambient recirculated air called volumetric radiation may penetrate volume receiver open permeable cells material way larger amount heat transfer surface supports solid gaseous heat transfer comparison tubular closed receiver finally heated air directed steam generator conventional steam turbine system study advanced cellular metal honeycomb structure designed manufactured tested use open volumetric receiver consists winded pairs flat corrugated metal foils technology based one primarily developed treatment combustion engine exhaust gases number variations pure linear honeycomb structure introduced increase local turbulence radial flow firstly set samples tested laboratory scale experiments determine effective properties solar thermal efficiency results compared theoretical predictions finally three promising materials used test research platform solar tower julich air outlet temperatures degrees achieved efficiencies state art technology currently used main receiver solar tower next lifetime models developed increase overall reliability technology elsevier ltd rights reserved
emergence big data use nosql sql technology rising rapidly among internet companies enterprises benefits include simplicity design horizontal scaling finer control availability nosql databases increasingly considered viable alternative relational databases organizations recognize schema less data model better method handling large volumes structured semi structured unstructured data captured processed today example nosql databases often used collect store social media data paper aims introduce concepts behind nosql provides review relevant literature highlights different nosql database types provide arguments adopting nosql small prototype application developed assess stated nosql benefits illustrate differences sql nosql approaches last section paper offers conclusions recommendations research expand upon research work
paper presents attitude towards parameter estimation problems based binary output observations dedicated context micro electronic devices micro electro mechanical systems mems self testing approach based maximum likelihood estimation logistic regression model finite impulse response fir system binary output data results proposed method compared appropriate approach micro electronic field various scenarios competitive compared one competition becomes bold case powerful signal noise ratio snr system
objectivesto assess prevalence specific headache disorders population older years seeking consultation due memory problems cognitive impairment methodswe verified occurrence headache symptoms impact headaches daily life headaches classified per international classification headache disorders edition ichd patients screened mini mental state examination mmse followed selective reminding test neuroimaging participants severe cognitive impairment dementia excluded resultsa total patients women mean age years screened january december patients suffered headaches common individual diagnoses probable migraine episodic tension type headache episodic migraine chronic migraine probable chronic migraine happened chronic tension type headache affected patients headaches routinely used symptomatic medications mean mmse scores similar patients without headaches different headache diagnoses conclusionsheadache disorders overall frequent headaches headaches requiring treatment commonly seen elderly seeking care cognitive decline properly assessed managed
cardiovascular disease one rampant causes death around world deemed major illness middle old ages coronary artery disease particular widespread cardiovascular malady entailing high mortality rates angiography often regarded best method diagnosis coronary artery disease hand associated high costs major side effects much research therefore conducted using machine learning data mining seek alternative modalities accordingly herein propose highly accurate hybrid method diagnosis coronary artery disease matter fact proposed method able increase performance neural network approximately enhancing initial weights using genetic algorithm suggests better weights neural network making use methodology achieved accuracy sensitivity specificity rates respectively alizadeh sani dataset elsevier rights reserved
although firefighting known engender high rate injury studies examined contribution physical exercise burnout coping strategies firefighting related injuries data collected population based sample male firefighters descriptive study nature site injuries relationships among firefighter injuries physical exercise burnout coping strategies examined sprains prevalent type injury followed tendinitis muscle tears two thirds injuries located ankle weekly hours physical exercise cognitive weariness work social support seeking problem focused coping emotional exhaustion significantly related injuries findings suggest physical exercise cognitive weariness considered risk factors french firefighter injuries whereas problem focused coping seen protective factor research needed explain relationship social support seeking injury elsevier ltd ergonomics society rights reserved
objective long term diabetes mellitus potentially associated occurrence microvascular damage study sought assess whether history prior gestational diabetes mellitus associated long term effects women microcirculation methods within scope long term follow viennese post gestational diabetes project women prior gestational diabetes mellitus well women previous pregnancy history gestational diabetes mellitus controls enrolled cross sectional study microvascular function assessed post occlusive reactive hyperaemia using laser doppler fluxmetry baseline perfusion biological zero peak perfusion time peak recovery time recorded compared groups results microvascular function assessed women prior gestational diabetes mellitus years women previous pregnancy without prior gestational diabetes mellitus years mean period time delivery assessment microvascular function years women prior gestational diabetes mellitus group years controls regarding microvascular function baseline perfusion biological zero peak perfusion time peak recovery time differ women prior gestational diabetes mellitus controls conclusion long term microvascular function appears impaired women prior gestational diabetes mellitus
emissions multiple hydrogen production pathways fossil sources evaluated compared fossil fuel production pathways china using life cycle assessment method considered hydrogen pathways gasoline reforming diesel reforming natural gas reforming soybean derived biodiesel biodiesel reforming waste cooking oil derived biodiesel reforming moreover emissions energy consumption fuel cell vehicles utilizing hydrogen different fossil sources presented compared electric vehicle internal combustion engine vehicle compression ignition engine vehicle results indicate fuel cell vehicles electric vehicle less greenhouse gas emissions energy consumption compared traditional vehicle technologies china based overall performance comparison five different fuel cell vehicles electric vehicle china fuel cell vehicles operating hydrogen produced natural gas waste cooking oil derived biodiesel show best performance whereas electric vehicle worse performance fuel cell vehicles high share coal electricity mix china emissions electric vehicle china level natural gas fuel cell vehicle share coal decreases around share renewable energy increases around electricity mix china copyright john wiley sons ltd
objective hypnotic suggestion empirically validated form pain control however underlying mechanism remains unclear methods thirteen fibromyalgia patients received suggestions alter clinical pain healthy controls received suggestions alter experimental heat pain suggestions delivered hypnotic induction blood oxygen level dependent bold activity measured concurrently results across groups suggestion produced substantial changes pain report main effect suggestion marginally larger changes induction main effect induction patients bold response increased pain report regions previously associated pain including thalamus anterior cingulate cortex controls bold response decreased pain report changes greater induction region interest analysis revealed largely linear patient responses increasing pain report control responses however higher suggestion increase decrease pain baseline conclusions based behavioral report alone mechanism suggestion could interpreted largely similar regardless induction type pain experience functional magnetic resonance imaging data however demonstrated larger changes brain activity induction radically different pattern brain activity clinical pain compared experimental pain findings imply induction important effect underlying neural activity mediating effects suggestion mechanism suggestion patients altering clinical pain differs controls altering experimental pain patient responses imply suggestions altered pain experience via corresponding changes pain related brain regions whereas control responses imply suggestion engaged cognitive control
background platelet rich plasma used frequently promote healing muscle injuries growth factors contained platelet rich plasma accelerate physiological healing processes use factors simple minimally invasive aim study demonstrate efficacy ultrasound guided injection platelet rich plasma muscle strains absence side effects materials methods fifty three recreational athletes enrolled study patients recruited emergency room university hospital parma according pre defined protocol every patient assessed ultrasound imaging evaluate extent degree muscle injuries grade lesions treated three ultrasound guided injections autologous platelet rich plasma every days platelet concentrate produced according standard methods variability platelet count platelet gel clinical use obtained adding thrombin concentrates standardised conditions outcomes assessed pain reduction muscle function recovery return sports activity ultrasound imaging tissue healing relapses local infections side effect treatment results cases muscle lesions healed fully ultrasound imaging pain disappeared muscle function recovery documented return sports activity single patient relapse year treatment discussion platelet rich plasma injected injury site one important factors rendering treatment effective maximise efficacy preliminary ultrasound must done accurately localise lesion guide needle corresponding lesion according current results document full muscle recovery relapse except one case platelet rich plasma ultrasound guided injection represents valid mini invasive treatment muscle injuries
study examines relationship interreligious contact negative attitudes towards religious group uses unique survey data collected authors among christian muslim students maluku yogyakarta indonesia mindanao metro manila philippines even taking self selection effects account interreligious friendships reduce negative attitudes towards religious group however casual interreligious contact increases negative group attitudes also individuals experienced interreligious violence negative group attitudes without experience experience interreligious violence influence effect interreligious friendships deteriorates relationship casual interreligious contact group attitudes perceived group threat important mechanism explaining effects positive negative interreligious contact elsevier inc rights reserved
onsite rainwater harvesting inexpensive water source indoor use also sustainable water management practice since may contribute reduction runoff volume peaks control non point source pollution aim paper provide method sizing rainwater harvesting tanks based local daily rainfall record served family size roof collection area roof type house water uses factors various methods used worldwide presented compared comparative application methods made using daily rainfall record meteorological station near kimmeria village xanthi northeast greece based proposed method optimum tank size computed allowing excess water overflow setting zero use public water supply method may result reduced tank sizes compared methods tested
analysis dna sequences data computational intensive problem therefore requires suitable parallel computing resources algorithms paper describe parallel algorithm dna sequence analysis determines many times pattern appears dna sequence algorithm engineered heterogeneous platforms comprise host multi core processors one many core devices combinatorial optimization use simulated annealing algorithm optimization goal determine number threads thread affinities dna sequence fractions host device overall execution time dna sequence analysis minimized evaluate approach experimentally using real world dna sequences various organisms heterogeneous platform comprises two intel xeon processors intel xeon phi processing device running possible experiments optimization method finds near optimal system configuration dna sequence analysis yields average speedup compared host device execution copyright john wiley sons ltd
xylem resistance cavitation important trait related ecology survival plant species vessel network characteristics vessel length connectivity could affect spread emboli gas filled vessels functional ones triggering cavitation hypothesized cavitation resistance xylem vessels randomly distributed throughout vessel network predicted single vessel air injection svai vulnerability curves vcs would thus affected sample length longer stem samples predicted appear resistant shorter samples due sampled path including greater numbers vessels evaluated vessel network characteristics grapevine vitis vinifera english oak quercus robur black cottonwood populus trichocarpa torr gray constructed svai vcs long segments also constructed vcs standard centrifuge method used computer modelling estimate curve shift expected pathways composed different numbers vessels three species svai vcs aeuro segments rose exponentially vulnerable aeuro segments aeuro curve shapes exponential consistent centrifuge vcs modelling data supported observed svai shifts related path length vessel network characteristics results suggest exponential vcs represent realistic curve shape individual vessel resistance distributions species network level presence vessels higher resistance cavitation may help avoid emboli spread tissue dehydration
data mining intrusion detection one cutting edge researches focus network security database information decision making due emergence new forms attacks intrusion network need new intrusion detection system would able detect new unknown attacks nevertheless complexity diversity network security alarm data ordinarily difficult analyze evaluate network security situation accurately intrusion detection protect network system attacks defend security used machine learning technology intrusion detection system order improve system performance effectively paper studying characteristics network data intrusion put forward intrusion detection system based rough set theory detect anomaly action network method extract detection rule model network connection data dealing incomplete data discrete data exit data mining effectively basic ideas techniques data mining based intrusion detection architecture real time data mining based ids discussed meanwhile mainly analyzed basic structure intrusion detection system application several machine learning methods intrusion detection include bayesian classification based method neural networks based method support vector machine based method svm experiments results show models methods generation framework proposed paper effectively detect network intrusion
studies evaluated whether retina involved migraine evaluation retinal nerve fiber layer rnfl examined ocular coherence tomography oct conflicting results aim case control study evaluate retina choroid migraine patients migraine aura mwa without aura moa chronic migraine evaluated age sex matched normal subjects selected healthy controls patients examined oct rnfl ganglion cell layer gcl foveal thickness choroidal thickness total macular volume tmv calculated right eyes left eyes seventy seven patients women moa mwa enrolled study patients compared significant reduction rnfl gcl thinner patients compared moreover showed reduction rnfl gcl compared migraineurs finally found significant inverse correlation rnfl thickness total number headache attacks per months data suggest involvement retina choroid migraineurs especially group although migraine episodic recurrent disease chronic nature might cause permanent structural abnormalities involving brain also retina
background lifestyle dietary advice typically precedes accompanies prescription statin medications however evidence adherence advice sparse objective compare saturated fat intake exercise alcohol consumption smoking statin users non users australia methods data analysed participants aged years australian diabetes obesity lifestyle study statin use smoking status physical activity self reported saturated fat alcohol intake measured via food frequency questionnaire multinomial logistic regression used compute adjusted odds ratios ors confidence intervals cis associations statin use four lifestyle factors models adjusted age sex education number general practitioner visits body mass index hypertension diabetes prior cardiovascular diseases results total participants used statin statin users less likely within highest quartile versus lowest quartile daily saturated fat intake compared non users statistically significant associations statin use smoking physical activity alcohol consumption conclusions smoking status alcohol consumption exercise level differ users non users statins however statin users less likely consume high levels saturated fat non users found evidence people took statins compensate poor diet lifestyle
objective objective identify predictors adherence hormonal contraceptives female veteran population study design retrospective cohort study female veterans san diego healthcare system study period april march patient followed year index date defined date first contraceptive prescription study time period adherence defined medication possession ratio income estimated using zip code based median household income split quintiles quintile lowest earning group logistic regression used analyze association adherence independent variables results total patients included final analysis majority population white receiving month supply medication following independent variables predictive increased adherence month supply versus month supply odds ratio confidence interval age group versus income quintiles versus quintile reference group following associated decreased adherence new start versus continuing user gyn provider versus primary care provider highest weight group versus lowest weight group conclusion hormonal contraceptive adherence veteran population optimal providing month supplies high value therapies hormonal contraceptives one strategy may improve adherence initiatives target lower socioeconomic status new start populations increase contraceptive adherence also considered implications adherence hormonal contraceptives well studied literature high value therapies identifying predictive variables adherence may implications establishing possible interventions refining benefit structures order increase adherence published elsevier inc
double cable system wide application prospects multispan suspension bridges longitudinal restraint stiffness double cable system tower studied paper two formulas derived calculate longitudinal restraint stiffness double cable system tower load distribution cables respectively mathematical model two span double cable suspension bridge created verify formulas tower top displacement cable force obtained formulas results good agreement results calculated fem effects important design parameters longitudinal restraint studied analysis shows restraint stiffness increases increasing unit weight bridge dead load distribution top cable sag ratio bottom cable elastic stiffness cables effects tower top displacement span length also analyzed suggestions given design double cable suspension bridge
quantum computing promises improve speed scalability computations classical computing hardware early stage quantum computer hardware development software frameworks support rapid prototyping quantum solutions small scale hardware simulators necessary explore application quantum algorithms hard computational problems present software library qxlib incorporates symbolic computation optimization functions quantum annealers one means enable rapid prototyping demonstrate effectiveness integer linear programming integer factorization problems
uses technology delivered mental health treatment options interventions delivered via computer smart phone communication information devices opposed primarily face face interventions proliferating however literature unclear effectiveness preventive interventions higher education students population technology delivered interventions tdis might particularly fitting beneficial meta analytic review examines technological mental health prevention programs targeting higher education students either without presenting problems universal prevention mild moderate subclinical problems indicated prevention systematic literature search identified universal indicated controlled interventions published unpublished involving college graduate professional students hypothesized overall mean effect sizes ess universal indicated interventions statistically significant differed significantly favoring indicated interventions skill training interventions universal indicated significant whereas non skill training interventions significant among indicated programs indicated interventions better outcomes obtained cases participants access support course intervention either person technology email online contact positive findings universal indicated prevention qualified limitations current literature improve experimental rigor future research provide detailed information level achieved implementation describe participant characteristics intervention content explore impact potential moderators mechanisms success collect post intervention follow data regardless intervention completion use analysis strategies allow inclusion cases partially missing data
introduction osteoarthritis one common causes musculoskeletal system ailments prevention disease comprehensive treatment proper health related behavior becomes extremely important factor maintaining optimal health condition aim study assess relationship reported pain disability level health related behaviors undertaken patients well acceptance disease materials methods study group consisted patients diagnosed according acr criteria method used study employed pain vas health assessment questionnaire disability index haq acceptance illness scale ais health behavior inventory izz results average age among respondents years age duration disease years pain experienced movement rest correlated positively physical disability haq studies indicated positive linear correlation age physical disability acceptance disease ais depends mostly age pain motion rest disability levels analysis health related behaviors izz indicates average severity declared behavior statistically significant physical disability haq conclusions acceptance illness significantly reduced age progressive levels disability well severity pain progressive levels disability younger age respondents motivate engage health beneficial behavior
accurate estimates biomass required relating ecosystem functioning atmospheric carbon regulation biomass may directly measured field sampling used calibrate biomass predictions remote sensing modelling field sampling generally entails measuring fresh mass individual trees shrubs estimating moisture contents representative sub samples used calculate dry mass errors estimation moisture content correction translated proportionally biomass prediction individual tree shrub care required ensure estimates unbiased precise possible numerous different protocols currently applied attain differing accuracy bias precision cost implementation dataset ground biomass agb individuals trees shrubs used assess protocols within among individual sampling likely provide cost effective estimates within acceptable bounds accuracy monte carlo analysis used explore key sources error within individual estimation results suggest estimates may based least bole crown components agb bias resulting based stem wood particularly young small individuals little gain accuracy attained intensive sub sampling foliage twig branches bark stem wood components moreover efficiencies may gained applying existing empirical models estimate proportion agb crown based easily measured variables stem diameter thereby avoiding resource intensive process partitioning obtain fresh weights measurements components however minimise bias important undertake sampling study site stratify sampling among individuals appropriate taxonomic grouping plant functional type age class given plant functional type size age strata given site precision coefficient variation average estimate achieved intensive within among individual sampling however precision achievable using recommended less intensive efficient protocol derive average least six individuals individual intensively sub sample bole crown components applied fresh weights components latter estimate may obtained partitioning agb highest efficiency predictions obtained application existing representative empirical relationships partitioning based size individual elsevier rights reserved
improved outcomes individuals autism spectrum disorder asd opened range potential pathways transition adulthood include attending college entering labor force achieving degree independent living less cognitively able individuals may eligible state benefits may enter supported employment programs attending college require careful support planning practitioners need familiar unique needs young adults asd research attempt define priorities individuals families asd making transition clarify value existing supports interventions
age related changes brain structure question interest broad field research structural decline consistently unambiguously linked functional consequences including cognitive impairment dementia one areas considered crucial importance throughout process medial temporal lobe primarily hippocampal region gender also considerable effect volume deterioration subcortical grey matter structures hippocampus influence agexgender interaction disproportionate volume changes might mediated hormonal effects brain hippocampal volume loss appears become accelerated postmenopausal period decline might significant influences neuroplasticity region hippocampus highly vulnerable pathological influences additionally menopause associated critical pathobiochemical changes involved neurodegeneration micro macrostructural alterations consequent functional deterioration critical hippocampal regions might result clinical cognitive impairment especially already decline cognitive reserve capacity several lines potential vulnerability factors appear interact menopausal period eventually leading cognitive decline mild cognitive impairment alzheimer disease focused review aims delineate influence unmodifiable risk factors neurodegenerative processes age gender critical subcortical structures light brain derived estrogen effects menopausal period appears key importance risk cognitive decline representing time special vulnerability molecular structural functional influences offering narrow window potential protective effects
project tackles history women group hoac workers brotherhood catholic action franco dictatorship transitional period democracy spain oral sources necessary methodology order analyze public participation social commitment catholic working women thanks personal experiences hoac members additionally personal stories hoac women essential source study evolution organization also difficulties group suffered considering gender roles defined church regime marked limited field action finally present project sheds light individual evolution many women became aware inequality courses activities organized hoac thanks began participate like male counterparts trade unions social struggles last decades franco dictatorship
proliferation low cost ieee zigbee wireless devices critical infrastructure applications presents security challenges network security commonly relies bit level credentials easily replicated exploited hackers unauthorized access mitigated physical layer phy security measures exploit device dependent emission characteristics sufficiently unique discriminate devices distinct native attribute dna fingerprinting phy based security measure computes statistical features extracted device emissions however dna fingerprints numerous correlated noisy therefore dimensional reduction analysis dra via feature selection therefore interest device classification dra feature subsets evaluated using multiple discriminant analysis mda classifier determining feature relevance mda generally dismissed prior fingerprinting work seldom considered applications mda feature relevance revisited using proposed eigen based mda loadings fusion mlf methodology mda classification models adopted used assess device identification classification verification performance authorized unauthorized rogue devices using claimed versus actual biometric methodology performance compared six dra methods using two sample kolmogorov smirnov test one way analysis variance test statistics wilk lambda ratio generalized relevance learning vector quantized improved relevance randomly selected proposed mlf method quantitative qualitative dimensionality assessment methods compared contrasted establish upper bounds number retained features experimentally collected zigbee emissions considered zigbee device classification verification performance using dra subsets compared full dimensional feature set results show dra via proposed mlf method superior robust competing methods
purpose klinefelter syndrome related testicular insufficiency causes low testosterone levels serum generally sex hormone levels bone mineral density bmd lower patients normal investigated effects testosterone replacement serum testosterone levels bmd patients materials methods december march patients xxy karyotype treated initial intramuscular injections long acting testosterone undecanoate nebido baseline second injections six weeks additional four injections administered intervals weeks second injection bmd measured lumbar spine left femoral neck ward triangle using dual energy ray absorptiometry medical histories physical examinations prostate specific antigen hematology serum chemistry conducted patient addition total testosterone sex hormone binding globulin levels measured results following testosterone replacement mean serum total testosterone increased significantly baseline total testosterone rose normal levels replacement patients mean bmd lumbar spine increased significantly similar increases bmd also observed femoral neck increase significant conclusion findings suggest testosterone replacement therapy may effective treating bmd deficiency men testosterone deficiency especially klinefelter syndrome
rats sign trackers sts prone attribute incentive salience reward cues manifest propensity approach contact pavlovian cues addiction like behavior sts also exhibit poor attentional performance relative goal trackers gts associated attenuated acetylcholine ach levels prefrontal cortex paolone demonstrate cellular mechanism linked ach synthesis accounts attenuated cholinergic capacity sts first found electrical stimulation basal forebrain increased cortical choline transporter cht mediated choline transport gts paralleled redistribution chts synaptic plasma membrane neither increases choline uptake translocation chts occurred sts second consistent uptake translocation alterations sts demonstrated reduced ability support cortical ach release vivo compared gts reverse dialysis elevate extracellular potassium levels third rats significantly likely develop sign tracking behavior treated systemically pavlovian conditioned approach training cht inhibitor consistent proposed mechanisms administration attenuated potassium evoked ach levels prefrontal cortex measured vivo microdialysis propose loss cht dependent activation cortical cholinergic activity sts degrades top executive control behavior producing bias bottom stimulus driven attention attentional bias contributes nonadaptive reward processing thus identifies novel mechanism support psychopathology including addiction
increasing demand electricity caused growing number electric vehicles might challenge future energy systems smooth integration electricity demand comprehensive knowledge characteristics essential analysis charging behavior patterns resulting load profiles become important premises crucial task three electric mobility studies germany southwestern region get eready izeus crome deliver comprehensive data use purpose paper analyze discuss mobility charging characteristics data detail derive empirical load profiles show affected charging management present model simulate loads based statistical characteristics conducted studies resulting charging load profiles show similar patterns studies developed simulation model results see supplementary data available online allow realistic representation demand analyses future energy systems elsevier ltd rights reserved
objective study objectives first evaluate success autologous chondrocyte implantation aci terms incidence surgical intervention including arthroplasty investigate predictors successful treatment outcome second objective derive tool predicting patient arthroplasty risk following aci design level prognostic study aci treated patients males aged years females aged years completed questionnaire surgery knee treated aci years previously factors commonly assessed preoperatively age gender defect location number previous surgery site preoperative lysholm score used independent factors regression analyses results final follow maximum years post aci patients undergone surgical intervention following aci twenty six patients underwent arthroplasty commonly females males cox regression analyses identified factors associated intervention age aci multiple operations aci patellar defects lower pretreatment lysholm scores nagelkerke six predictive items associated risk arthroplasty following aci nagelkerke used develop oswestry risk knee arthroplasty index internal cross validation conclusion single center study identified factors age gender location number defects number previous operations lysholm score aci appear influence likelihood aci patients progressing arthroplasty used information propose formula tool could aid treatment decisions improve patient selection aci
design realization new low cost instrument real time measurement blood flow particularly developed extracorporeal blood circulator systems presented self mixing interferometric technique combined dedicated analog signal processing system adopted perform accurate flow measurement developed system exhibits accuracy lower cost entire measuring system estimated euros
work focused parallel algorithms efficient global optimization firstly multiple points infill criterion named developed adopts entropy precisely measure uncertainty kriging surrogate balances global exploration local exploitation multiple points infill sampling criteria secondly given computational difficulties kriging large size training data domain decomposition optimization strategy proposed ensures small size training data several mathematical functions one engineering problem employed testing examples results show comparing several methods obvious advantage solving complex optimization problems large scale parallel computing environment domain decomposition optimization strategy could improve stability optimization without sacrificing optimization efficiency
due crucial highly consequential task utmost importance understand levers leading effectiveness multidisciplinary emergency management command control emcc teams argue formal emcc team leader needs initiate structure team meetings support organizing work well facilitate team learning especially team learning process constructive conflict sample emcc teams performing realistic emcc exercise including one two team meetings sum coded team leader verbal structuring behaviors events rated constructive conflict external experts rated team effectiveness field experts results show leaders effective teams use structuring behaviors often except asking procedural questions decreasingly time support constructive conflict clarifying making summaries conclude command decision decreasing frequency time
primal dual hybrid gradient method pdhg originates arrow hurwicz method widely used solve saddle point problems particularly image processing areas introduction combination parameter chambolle pock proposed generalized pdhg scheme theoretical numerical advantages analyzed except special case combination parameter pdhg casted proximal point algorithm framework due lack symmetry matrix associated proximal regularization terms pdhg scheme nonsymmetric also sense one variable updated twice updated iteration nonsymmetry features also explain theoretical issues remain challenging generalized pdhg schemes example worst case convergence rate pdhg measured iteration complexity nonergodic sense still missing paper consider generalize pdhg propose algorithmic framework generalized pdhg schemes saddle point problems algorithmic framework allows output pdhg subroutine updated correction steps constant step sizes investigate restriction onto step sizes conduct convergence analysis algorithmic framework algorithmic framework turns include existing pdhg schemes special cases immediately yields class new generalized pdhg schemes choosing different step sizes correction steps particular completely symmetric pdhg scheme golden ratio step sizes included theoretically advantage algorithmic framework worst case convergence rate measured iteration complexity ergodic nonergodic senses established
complementary terrestrial mobile communication systems mobile satellite communication system fill gaps covered terrestrial network provides irreplaceable solution emergency communication disaster pave road future satellite terrestrial integrated communication networks itu invited proposals candidate radio interface technology rit satellite component international mobile telecommunications imt advanced china proposed rit long term evolution lte satellite candidate considered imt advanced satellite technology submitted lte satellite candidate rit specified based terrestrial lte advanced fdd standards developed gpp considering satellite requirements number modifications lte advanced made adapt satellite radio transmission environments paper provides general introduction new characteristics lte satellite
neuroimaging studies anorexia nervosa suggest altered food reward processing may result dysfunction limbic reward cortical control centers brain fmri study aimed index neural correlates food reward subsample individuals restrictive twelve currently ill fourteen recovered individuals sixteen healthy controls participants shown pictures high low calorie foods asked evaluate much wanted eat one following four hour fast whole brain task activated analysis followed psychophysiological interaction analysis ppi amygdala caudate group observed differential pattern activation lateral frontal pole increasing following presentation high calorie stimuli decreasing presentation low calorie food pictures opposite seen healthy control group addition decreased activation food pictures observed somatosensory regions group ppi analyses suggested hypo connectivity reward pathways caudate somatosensory visual processing regions group significant group differences observed recovered group currently ill healthy controls ppi analysis taken together findings understanding neural processes may underpin avoidance high calorie foods might exacerbate development compulsive weight loss behavior despite emaciation
vibration physical phenomenon involving repeated oscillatory movements fluctuations certain frequency typically undesirable many applications since may cause undue failure damage system paper vibration three degree freedom dof model representing short length drive shaft effectively robustly suppressed implementation novel active force control afc used conjunction classic proportional integral derivative pid controller shaft vibration caused support constraint operation simulated using matlab simulink considering number operating loading conditions results proved pure pid controller implemented vibration indeed reduced expense longer execution time producing noticeable frequency oscillation slight offset hand afc loop engaged adding directly series pid controller pid afc produce dof controller without need tune pid controller gains vibration significantly reduced amplitude hovering zero datum without offset yielding extremely low frequency trending penerbit utm press rights reserved
background lateral center edge angle lcea important measurement understanding acetabular morphology multiple interpretations misunderstanding lcea relationship acetabular dimensional morphology may result misdiagnosis poor outcomes purpose determine discrepancy bone edge sourcil edge lcea measurements anteroposterior radiographs determine anatomic location sourcil edge bone edge lcea measurements study design cohort study diagnosis level evidence methods lcea measured radiographs sourcil edge bone edge images symptomatic hips computed tomography coronal slices producing lcea matching magnitude lcea identified coronal slices mapped sagittal image acetabulum divided standard clockface anterior superior identified clockface locations corresponding sourcil edge bone edge lcea measurements paired tests identified differences magnitude location bone sourcil lceas limits agreement calculated differences measures intraclass correlation coefficients iccs assessed inter intraobserver repeatability results radiographs bone edge lcea mean degrees degrees degrees greater sourcil edge lcea sagittal clockface location sourcil edge lcea anterior compared sagittal clockface location maximum bone edge lcea respectively degrees sourcil edge bone edge measurements coronal slice corresponding sourcil edge lcea significantly anterior slice corresponding bone edge lcea significant difference similar location less pronounced hips difference degrees sourcil edge lcea occurred bone edge lcea occurred conclusion sourcil edge lcea represents anterosuperior acetabular coverage bone edge lcea represents superior lateral coverage information used preoperative evaluation perioperative planning hip preservation procedures
investigation magnetic properties microwave resonance phenomena nanocomposites based opal matrices containing particles intermetallide feni feni carried interactions lead resonance changes transmission reflection coefficients determined electromagnetic properties measured millimeter frequency range special attention paid comparison static dynamic magnetic properties nanocomposites frequency dependences magnitude lines resonance features obtained spectra resonance antiresonance studied conditions magnetic antiresonance observed clarified ray phase analysis nanocomposites performed structure studied elsevier rights reserved
paper presents bit folding analog digital converter adc using switched capacitors architecture conversion achieved signal crosses determined voltage level time voltage value added subtracted analog input signal adc proposed consists eight identical stages perform conversion one bit time stage consists amplifier circuit gain using switched capacitor adc designed cmos standard technology supplied proposed adc consumes power presents following results conversion time sndr signal noise plus distortion ratio
study aimed verify prevalence characteristics sports injuries determine association physical activity level perception health related quality life hrqol brazilian basketball master athletes cross sectional study conducted male master athletes years age mean hrqol assessed using medical outcomes study short form evaluated using international physical activity questionnaire information regarding collected using reported morbidity survey poisson regression estimated prevalence ratio used measure association hrqol majority athletes showed high prevalence reported one injury occurred training primarily affected lower limb adjusted regression models showed positive association functional capacity confidence interval physical component hrqol furthermore negatively associated hrqol functional capacity physical aspects pain social functioning emotional aspects mental health domains physical component mental component results highlighted master athletes showed high prevalence primarily lower limbs positively correlates physical hrqol domain whereas may decrease hrqol levels physical mental domains
objective determine whether increase slow wave sleep associated modafinil treatment chronic cocaine users mediates improved clinical outcomes method cocaine dependent participants randomized receive modafinil placebo daily period inpatient treatment followed six weeks outpatient treatment participants underwent polysomnographic sleep recording inpatient treatment prior starting modafinil outpatient treatment consisted weekly cognitive behavioral therapy contingency management used promote participation treatment research demands including thrice weekly visits outpatient phase urine toxicology screens assessments primary clinical outcome percent urine toxicology screens negative cocaine results modafinil treatment associated higher mean percentage cocaine free urine screens increase sleep time change sleep time mediated higher rate cocaine free urine screens modafinil treatment also associated consecutive days abstinent outpatient treatment greater survival abstinence higher daily rates abstinence less sleep degradation typically associated abstinence chronic cocaine use conclusions morning dosed modafinil improves slow wave sleep abstinent cocaine users inpatient setting effect statistical mediator improved clinical outcomes associated continued modafinil treatment high rates abstinence achieved trial suggest promoting healthy sleep physiology inpatient setting may important effective treatment cocaine dependence elsevier ireland ltd rights reserved
paper deals generalization brayton moser network decomposition related structural properties relatively large class finite dimensional strictly causal systems described state space representation form resulting energy metric function defined dissipative systems induced output signal dissipation power demonstrated power oriented approach determines structure system representation well corresponding system state space topology special form physically correct internal structure equivalent state space representation derived natural consequence strict causality state space energy conservation dissipativity assumption state minimality requirement
technologies intermittent cutting problem endpoint cutting problem cutting sheet material belong called resource saving technologies technologies allow overlap contours cut details paper devoted review mathematical models cut lie details technologies algorithms defining cutter route according technological restrictions ifac international federation automatic control hosting elsevier ltd rights reserved
many scientific fields empirical models employed facilitate computational simulations engineering systems example fluid mechanics empirical reynolds stress closures enable computationally efficient reynolds averaged navier stokes simulations likewise solid mechanics constitutive relations stress strain material required deformation analysis traditional methods developing tuning empirical models usually combine physical intuition simple regression techniques limited data sets rise high performance computing led growing availability high fidelity simulation data data open possibility using machine learning algorithms random forests neural networks develop accurate general empirical models key question using data driven algorithms develop empirical models domain knowledge incorporated machine learning process paper specifically address physical systems possess symmetry invariance properties two different methods teaching machine learning model invariance property compared first method basis invariant inputs constructed machine learning model trained upon basis thereby embedding invariance model second method algorithm trained multiple transformations raw input data model learns invariance transformation results discussed two case studies one turbulence modeling one crystal elasticity shown cases embedding invariance property input features yields higher performance significantly reduced computational training costs elsevier inc rights reserved
effects flood induced bed elevation channel geometry changes flood hazards largely unexplored especially case multiple floods site study quantified evolution river channel floodplain geometry repeated series hypothetical extreme floods using full hydro morphodynamic model lhmm experiments designed examine consequences channel geometry changes channel conveyance capacity subsequent flood dynamics results revealed extreme floods play important role adjusting river channel become efficient subsequent propagation floods channel scour sediment distribution greatly improve conveyance capacity channel subsequent floods hypothetical sequence floods response bed elevation net degradation sediment transport successively weakened even floods magnitude changes river channel geometry led significant impact flood hydraulics thereby flood hazards found flood induced channel erosion disconnect channel floodplain resulting reduction floodwater storage thus frequency extent subsequent overbank flows floodplain inundation decreased reduced downstream flood attenuation increased downstream flood hazard combination summary results suggest changes channel capacity due extreme floods may drive changes flood hazard assumption unchanging river morphology inundation modelling therefore open question flood risk management elsevier rights reserved
one important challenges creation intelligent environments specifications intelligent behaviours system exhibit processing situations computationally demanding report advances specification rule based language allows natural expression situations interest occur intelligent environments language focuses quasi real time situations includes new temporal operators allow natural reference time instants intervals explained system implemented system validated within smart office scenario
evolution temperatures internal combustion engines cold start quite important greatly affects fuel consumption vehicle emissions paper advanced thermal management model presented used automotive diesel engine order determine evolution different temperatures warm stage paper focuses complete description engine components coolant circuit lubricant circuit objective calculate heat exchanges thermal masses sub models cylinder head engine block pistons oil sump fluids experiments engine realized order calibrate model heat release friction losses also obtain temperature evolutions transient stage last results used order validate model approach gives possibility determine coolant oil temperature evolution minimum nodes relatively short calculation time evolution coolant temperature vehicle nedc cycle cold start studied good agreement obtained finally model used order study possibilities reduce vehicle mass reduction engine mass elsevier ltd rights reserved
cnidaria symbiotic copepods group invertebrates greatest numbers associates occur hard corals review scattered literature diversity taxonomic composition scleractinian associated copepods hosts revealed total coral species representing genera families serve hosts copepods present copepod species representing genera families three orders recorded associates scleractinian corals total included cyclopoids siphonostomatoids seven harpacticoids within cyclopoida representation species varied greatly among families disproportionate number species belonging anchimolgidae species xarifiidae species data host utilization geographical distribution copepods living symbiotically hard corals synthesized host specificity patterns highlighted prevalence intensity density biodiversity copepod infection colonies reef building coral pocillopora damicornis linnaeus nanwan bay southern taiwan documented july november hypothesized certain environmental factors physiological coral traits density symbiodinium could influence infection parameters analysis revealed ectoparasitic copepods likely infect damicornis asteropontius minutus kim accounted total copepod density july september temperatures high bleaching occurred similar sampled colonies data showed copepod virulence may related life history strategies well symbiodinium density surface area host coral colonies concentration nitrate chlorophyll surrounding seawater tracking abundance diversity performance infectious copepods prior throughout natural bleaching event potential use parasites bioindicators predicting future physiological performance damicornis response environmental change particularly bleaching events may ultimately explored developed maximized humesimyzon kim previously placed asterocheridae tentatively transferred recently resurrected family coralliomyzontidae authorship spelling pseudanthessius thorellii brady corrected
since conventional evacuation drills adequately simulate disaster situations participants feel sense tension evacuation developed game based evacuation drill gbed system focuses situational audio visual realities scenario based interactivity improve visual reality gbed adopt simple augmented reality binocular opaque head mounted display hmd simple represents vague extensive disaster situations rain fog smoke fire superimposing overall disaster situations dynamic three dimensional computer graphics onto real time vision captured stereo camera attached hmd
purpose evaluate effectiveness individual self management occupational therapy intervention program smooth versus relaxation performance satisfaction relevant daily activities individuals multiple sclerosis related fatigue single blind randomized controlled trial patients smooth relaxation randomly allocated three individual sessions focusing pacing prioritizing ergonomics self management smooth stress management relaxation relaxation outcomes blind assessor canadian occupational performance measure copm primary modified fatigue impact scale checklist individual strength short form health measure copm improved smooth relaxation group intervention months later copm performance copm satisfaction nonsignificant group differences showed trend favor smooth modified fatigue impact scale checklist individual strength short form health measure subscales change clinically relevant changes copm performance scores found patients smooth versus relaxation group interventions seem feasible approaches improve performance satisfaction relevant daily activities people sustained effect months neither program altered change fatigue impact quality life future studies larger sample sizes needed copyright wolters kluwer health inc rights reserved
recent advance technology enables researchers gather store enormous data sets ultra high dimensionality bioinformatics microarray next generation sequencing technologies produce data tens thousands predictors biomarkers hand corresponding sample sizes often limited classification problems predict new observations high accuracy better understand effect predictors classification desirable often necessary train classifier variable selection literature sparse regularized classification techniques popular due ability simultaneous classification variable selection despite success sparse penalized method may low computational speed dimension problem ultra high overcome challenge propose new sparse regression based multicategory classifier rec method uses simplex represent different categories classification problem major advantage rec optimization decoupled smaller independent sparse penalized regression problems hence solved using parallel computing consequently rec enjoys extraordinarily fast computational speed moreover rec able provide class conditional probability estimation simulated examples applications microarray next generation sequencing data suggest rec competitive compared several existing methods
interpersonal reality monitoring irm refers ability evaluate whether people memories reflect real imagined events current work examined irm whether affected training feedback found people better chance ability accurately make judgement improved reduced appropriate inappropriate training respectively understanding irm implications applied psychologists interested people evaluate others descriptions past events eyewitness testimony
wood widely used material various applications dimensional stability practical interest design performance wooden materials change geometry wood depends upon environmental conditions relative humidity well internal structure composition wood work presents measurement technique development associated system measurement strain changes wood samples relative humidity developed system capable measuring strain change relative humidity temperature compensation system comprises strain gauge based strain measurement unit sensor related signal conditioning circuit along temperature sensor strain gauge signal conditioning based quarter bridge method high precision resistors excited source whole system centered bit risc microcontroller picfk built bit analog digital converter adc used read strain ambient temperature directly read temperature digital converter using zacwire interface measurement system calibrated using cantilever stainless steel used collecting analyzing data four wood samples uncertainties associated measurements reported paper experimental results obtained wood samples presented elsevier ltd rights reserved
paper presents literature review field summarizing software artifacts focusing bug reports source code mailing lists developer discussions artifacts jan apr numerous summarization techniques approaches tools proposed satisfy ongoing demand improving software performance quality facilitating developers understanding problems hand since aforementioned artifacts contain structured unstructured data time researchers applied different machine learning data mining techniques generate summaries therefore paper first intends provide general perspective state art describing type artifacts approaches summarization well common portions experimental procedures shared among artifacts moreover discuss applications summarization tasks hand achieved summarization next paper presents tools generated summarization tasks employed summarization tasks addition present different summarization evaluation methods employed selected studies well important factors used evaluation generated summaries adequacy quality moreover briefly present modern communication channels complementarities commonalities among different software artifacts finally thoughts challenges applicable existing studies general well future research directions also discussed survey existing studies allow future researchers wide useful background knowledge main important aspects research field
background heart failure disease neurohumoral dysfunction current pharmacological therapies improved mortality rates thus requiring additional new strategies waon therapy patients may complementary strategy peripheral vasodilation via nitric oxide hypothesized waon therapy would improve neurohumoral factors natriuretic peptides renin angiotensin aldosterone system raas methods results plasma samples collected patients enrolled waon chf study waon therapy control treatment type bnp type cnp aldosterone aldo levels measured respective specific radioimmunoassays although clinical parameters significantly improved waon group compared control group bnp aldo cnp levels statistically different groups subanalysis patient variables bnp levels improved waon group treated angiotensin converting enzyme inhibitor angiotensin receptor blocker spironolactone addition aldo levels improved waon group patients diabetes mellitus hypertension inotrope use cnp levels improved waon group patients estimated glomerular filtration rate min changes observed control group conclusions waon therapy may accelerate favorable actions raas modulators waon chf study umin
relationship contaminated drinking water trace elements thyroid diseases hypertension liver functions disorder kidney functions disorder studied research thyroid diseases hypertension liver functions disorder kidney functions disorder due contaminant drinking water trace elements present study concerned water toxicity heavy metals belonging important pollutants strong relationship contaminated drinking water heavy metals stations water shopping hail ksa thyroid diseases hypertension liver functions disorder kidney functions disorder identified study diseases apparently related contaminant drinking water heavy metals kidney functions disorder related contaminate drinking water lead cadmium liver functions disorder copper molybdenum thyroid functions disorder iodide copper cadmium long term exposure lead cadmium zinc iron arsenic drinking water mainly related primarily form thyroid liver kidney functions disorder studies diseases suggest abnormal incidence specific areas related toxic materials groundwater thereby led contamination drinking water areas result study showed increase thyroid hormones liver functions test ast alt enzymes also increase hypertension kidney functions test creatinine uric acid increases due pollution drinking water heavy metals
polydatin natural precursor resveratrol variety biological activities including anti tumor effects however underlying molecular mechanisms anti cancer activity fully elucidated present study demonstrated significantly inhibited proliferation molt leukemia cell line dose time dependent manner using cell counting kit assay also dose dependently increased apoptotic rate caused cell cycle arrest phase molt cells revealed flow cytometry addition dose dependently decreased mitochondrial membrane potential led generation reactive oxygen species molt cells western blot analysis revealed expression anti apoptotic protein cell lymphoma bcl decreased whereas pro apoptotic protein bcl associated increased furthermore expression two cell cycle regulatory proteins cyclin cyclin suppressed note pro apoptotic cell cycle inhibitory effects potentiated janus kinase jak inhibition conclusion results present study strongly suggested promising therapeutic compound treatment leukemia particularly combination jak inhibitors
discharge iodine containing wastewater environment lead water pollution due toxicity radioactivity iodine iodine isotopes versatile adsorbent effectively adsorb iodine high demanded issue work hierarchically porous bismuth oxide layered double hydroxide bio ldhs composites prepared based biological template techniques prepared composites show enhanced iodine adsorption capacity compared ldhs fibers ldhs fibers hierarchical architectures synthesized directly growth nanoscaled ldhs platelets alo fiber surfaces bio ldhs composites sponge like structures prepared desorption bio surfaces ldhs fibers iodine adsorption behavior bio ldhs composites examined sodium iodine aqueous solutions appropriate iodine adsorption obtained neutral maximum adsorption capacity langmuir model successfully describes iodine adsorption isotherms pseudo second order kinetic model better describing iodine adsorption kinetics onto bio ldhs composites since bio ldhs composites show near complete removal iodine ions prepared bio ldhs composites expected practical applications iodine adsorbent wastewater treatment elsevier ltd rights reserved
deficiencies retrograde transport mediated retromer complex described alzheimer disease genetic manipulation retromer modulates brain amyloidosis mice however whether complex altered development like phenotype remains unknown study assayed expression levels vacuolar sorting protein vps vps vps cargo proteins cation independent mannose phosphate receptor sortilin related receptor brains controls ages months cortex showed age dependent decrease vps levels proteins cerebellum unchanged age neuronal cells expressing human amyloid beta precursor protein swedish mutant also reduced retromer complex levels however incubation pharmacological chaperone dose dependently restored levels together reduction amyloid beta study first show transgenic mouse model changes expression levels retromer complex age region dependent complex viable therapeutic target since deficiency restored pharmacologically retromer chaperone elsevier inc rights reserved
introduction neuroinflammation crucial mechanism pathophysiology neurodegenerative diseases pathophysiology cerebrospinal fluid csf ykl indicator microglial activation recently identified proteomic studies candidate biomarker alzheimer disease areas covered review impact csf ykl pathophysiological biomarker neurodegenerative diseases csf ykl concentrations shown predict progression prodromal mild cognitive impairment dementia moreover positive association csf ykl biomarkers neurodegeneration particularly total tau protein reported asymptomatic preclinical stage neurodegenerative diseases albeit preliminary current data support association apoe epsilon status csf ykl concentrations interpreting diagnostic prognostic significance csf ykl concentrations neurodegenerative diseases potential confounders including age metabolic cardiovascular risk factors diagnostic criteria selecting cases controls need considered expert opinion commentary csf ykl represents pathophysiological biomarker reflecting immune inflammatory mechanisms neurodegenerative diseases associated tau protein pathology besides associated tau pathology csf ykl adds growing array biomarkers reflecting distinct molecular brain mechanisms potentially useful stratifying individuals biomarker guided targeted anti inflammatory therapies emerging precision medicine
background people diabetes comorbid severe mental illness smi form growing population risk increased mortality morbidity compared diabetes smi alone increasing interest interventions target diabetes smi order help improve physical health reduce associated health inequalities however lack consensus outcomes important comorbid population trials differing focus physical mental health core outcome set includes outcomes across conditions relevant patients key stakeholders needed methods study protocol describes methods develop core outcome set use effectiveness trials self management interventions adults comorbid type diabetes smi use modified delphi method identify rank agree core outcomes comprise two round online survey multistakeholder workshops involving patients carers health social care professionals health care commissioners experts academic researchers third sector organisations also select appropriate measurement tools outcome proposed core set identify gaps measures exist discussion proposed core outcome set provide clear guidance outcomes measured minimum trials interventions people coexisting type diabetes smi improve future synthesis trial evidence area also explore challenges using online delphi methods hard reach population examine differences opinion outcomes matter diverse stakeholder groups
tumour necrosis factor tnf blocking agents revolutionized treatment psoriasis psoriatic arthritis concerns remain increased susceptibility infection onset malignancies use tnf agents patients hiv infection undergoing immunosuppressant treatment debated report cases severe plaque psoriasis patient hiv infection liver transplant recipient successfully treated etanercept anti tnf agent without notable side effects
although improvements body image shown longer lasting resistance training research short term effects currently lacking present study set test hypothesized beneficial effect single bout resistance training global specific body fat muscularity related body image states male exercisers additionally moderating effect drive muscularity explored controlled crossover study experienced weight trainers received session resistance training session aerobic exercise cycling session magazine reading body image states assessed immediately condition hypothesized resistance training cycling reading led significant increase perceived muscularity silhouette measure body image states exercise conditions led significant decrease perceived body fat resistance training resistance training held true men lower drive muscularity scores returned baseline levels even single bout resistance training yields short term improvements men body image states muscularity fat dimension may act reinforcer exercise behavior present findings might foster understanding body image factors contribute development excessive weight lifting behavior
paper focuses design control active suspension system tubular linear motor integrated spring damper system vehicle spring takes weight vehicle therefore electric linear motor designed compact provide forces adjust damping characteristic design construction active suspension system control strategy validation measurements test bench presented
assessed propensity false memories among patients obstructive sleep apnoea syndrome osas twenty one patients osas controls matched sex age education recruited encoding adaptation deese roediger mcdermott paradigm used induce false memories retrieval participants completed forced choice recognition task distinguish memories based verbatim traces based gist traces task encouraged retrieval based either gist verbatim traces groups performed similarly however task required retrieval based solely verbatim traces osas patients exhibited poor discrimination produced false memories finding osas leads increased propensity produce false memories discussed within framework fuzzy trace theory activation monitoring theory
study explored aged care support workers perceptions health influenced job highlighting similarities differences working community based institution based care support workers working two institution based three community based aged care organisations invited participate semi structured interviews undertaken ten participants open ended questions probed participants perceptions health related work data analysed general inductive approach four central themes identified many related mental opposed physical health love job described various sources satisfaction participants factors commonly overrode negative aspects stress encompassed negative influences aspects health support described positive influences health supported participants job physicality described physical nature job positive negative impact participants health support workers perform numerous tasks often impact upon health aspects job may impact health worker improved communication support management well recognition support workers contribution society could targeted enhance support worker health additional training reduced time pressure may also represent aspects improvement optimise support workers physical health
computation fluid mechanics problems moving boundaries including fluid structure interaction fluid mesh deformation common problem solved automatic mesh deformation technique large deformations fluid mesh presented basis pseudo solid method fluid mesh motion governed equations elasticity two dimensional mathematical model linear elastic body built using finite element method numerical result shows proposed method better performance moving fluid mesh without producing distorted elements classic one step methods
ambient intelligence ambient assisted living systems required provide natural user experience interaction resolved using devices modalities adapted user abilities preferences even environment conditions variety devices technologies diversity scenarios developing interaction systems complicated task paper proposes abstraction framework development ami aal systems effectively improves portability systems different environments allows developers design implement single capable deployed different devices modalities regardless physical location
two experiments explored influence affective state mood inadvertent plagiarism memory failure individuals either misattribute source idea rather true originator simply recall encountered idea claim novel using paradigm participants generate word puzzle solutions later recall solutions created opportunity participants mistakenly claim ownership items fact initially generated computer partner results experiments suggest participants induced sad mood solving word puzzles made fewer source memory errors induced happy mood results experiment also imply sad mood reduces item memory errors implications appraisal theories affect information hypothesis discussed
bioethicists argue conscientious objectors health care justify objectors military provide reasons explain exempt offering services find offensive two versions view literature giving different standards justification show views either permissive would result problematic exemptions based conscience restrictive would produce problematic denials exemption develop middle ground position believe better combines respect conscience healthcare professionals concern duties owe patients claim short insofar objectors justify according standard defend rather according standards others developed
multiphysics based simulation technique developed based finite element method characterization high frequency integrated circuits ics integrated microchannel cooling multiphysics cosimulation includes full wave electromagnetic fluid transient conjugate heat transfer analyses incompressible fully developed flows governing equations fluid flow decoupled temperature velocity field obtained analytically full wave electromagnetic transient conjugate heat transfer analyses coupled temperature dependent material properties efficiency simulation enhanced adaptive time stepping scheme domain decomposition scheme called finite element tearing interconnecting feti feti enabled parallel computing capability efficiency proposed simulation analyzing practical large scale ics demonstrated numerical examples effectiveness heat removal integrated microchannel cooling thermal impact high frequency characteristics designs also demonstrated
past two decades growth renewable energy sources electricity res largely driven market support policies schemes designed drive deployment basis specific subsidies sustained time allow larger costs well limit investor risk policies proven effective way designed date led costly market distortions becoming difficult ignore penetrations reach unpreceded levels context growing concern provide critical analysis design elements res support schemes focusing affect trade promoting efficiently integrating res emphasis structure incentive payment end turns cornerstone efficient integration conclude needed well designed developed capacity based support mechanism complemented post compensations defined reference benchmark plants mechanism currently implemented spain alternative good properties major goal truly market integration approach robust future developments technology cost performance market penetration res
background aim study explore efficacy guizhifulingwan gfw treatment climacteric syndrome women methods design single center randomized placebo controlled parallel group design pilot trial fifty participants climacteric syndrome randomly allocated gfw placebo group ratio participants administered gfw placebo granules three times day weeks followed weeks primary outcome mean change menopause rating scale score weeks randomization secondary outcomes include world health organization quality life bref scores degrees upward movement lower abdominal resistance tenderness blood stasis pattern questionnaire scores results blood tests including assays lipid profile high sensitivity reactive protein follicle stimulating hormone estradiol feasibility outcomes include recruitment completion rates adherence medication discussion results study provide basic data design large scale clinical trial evaluating efficacy gfw treatment climacteric syndrome women
although borderline personality disorder bpd frequently characterized nonsuicidal self injurious behavior nssi suicide attempts suicidal ideation suicide threats unclear whether behaviors precursors bpd adolescence study examined self harm suicide related behaviors development bpd adolescence adulthood psychiatrically hospitalized adolescents participants adolescents consecutively admitted psychiatric hospitalization self harm suicide related behaviors adolescents completed self report questionnaires assessing self harm suicide related behaviors maladaptive familial behavior peer victimization upon admission admission diagnoses history sexual physical abuse abstracted medical psychiatric records five years index hospitalization medical psychiatric records systematically reviewed information diagnoses collected using multivariable logistic regression analyses predicted bpd beyond nssi years later odds ratio confidence interval traditional risk factors bpd predictive bpd year follow suicidal threats important risk factor adolescents engage self harm suicide related behaviors may differentiate adolescents develop bpd adults implications research treatment discussed
paper reports recent advances development symbolic asymptotic modeling software package called memsalab used automatic generation asymptotic models arrays micro nanosystems precisely model partial differential equation asymptotic method approximate another partial differential equation numerically simulated reasonable time challenge consists taking account wide range different physical features geometries thin structures periodic structures multiple nested scales etc main purpose software construct models incrementally model features included step step idea conceptualized name extension combination presented first time user friendly language recently introduced also shortly discussed illustrate mathematical operations need implemented memsalab example asymptotic model stationary heat equation micro mirror array developed astrophysics
recognizing need information sharing implications development line plant databases advocated present article provides details development web enabled bioresource information centre floral resources himachal pradesh western himalaya mysql database presently houses information similar plant species information pertains distribution life form population local name taxonomy image use conservation status alien species twelve tables form backbone repository website creation database interface implemented using wordpress cms written php designing graphic user interface done using html css php javascript jquery site allows basic guided search compatible major browsers operating systems dynamic provides user option sharing information
purpose purpose paper explore engage connections evolving technology internet things iot notions convenience particular concept alpha convenience introduced order articulate broad scope internet everything connectivity called alpha convenience design methodology approach recommendations constructive technology assessment followed order evaluate technology implementation seven value drivers articulated fleisch utilized order envision specific aspects findings three critical aspects relating alpha convenience identified discussed gossiping technology personalization disempowered smartphone user argued extreme forms convenience shift traditional areas human agency onto technology also noted alpha convenience tends develop ubiquitous feature future society making difficult impossible opt research limitations implications paper focusses one powerful concept although iot merely one several terms used deliberate role next generation information technology society notable competitors include semantic web ubiquitous computing pervasive computing ambient intelligence social implications iot predicted intrusive feature everyday life paper identifies important aspects originality value first critical discussion iot convenience paper aims conceptual innovation overall substantial lack critical scrutiny emerging ideas iot
although opportunities women sport usa grown exponentially since title became law areas significant loss persistent stalls women advancement sport papers issue discuss title stepping looking glass suggests need beyond conventional discussions female athletes uncover new directions women sport physical activity countries around world discover future women sport papers special issue presented variety topics including nine papers address gender issues sport microaggessions take place sport women media role reporting status sport women sexual identity sport
across literature review supporting spirituality nursing care older adults dementia concerned supporting religious activity enabling connections nurses reflections spirituality nonverbal communication benefits support spirituality seen reciprocal occur everyday nursing
paper looks two distinct approaches kinetic facades smart building assemblies reminiscent designs institut monde arabe hoberman simon center first approach uses arduino microcontroller guided kinetic components distinct assemblage elements performing dedicated function sensor actuator logical processing unit second approach incorporates custom designed smart materials shape memory alloys smas complement replace need electrically operated sensors actuators also eliminate microcontroller since arrangement material performs computational functions paper discuss case studies use physical computing smart material models vehicles discuss value approach adaptive design architecture building observations paper looks conceptual aspects integrated hybrid system combines computation approaches unique opportunities inherent hybrid designs
independent component analysis ica one basic tools data analysis aims find coordinate system components data independent existing methods based minimization function fourth order moment kurtosis skewness third order moment received much less attention paper present competitive approach ica based split gaussian distribution well adapted asymmetric data consequently obtain method works better classical approaches especially case underlying density symmetric typical situation color distribution images elsevier ltd rights reserved
aims beta carotene natural anti oxidant used treatment cancer cardiovascular diseases recently ameliorating function beta carotene osteoporosis implicated however precise mechanism beta carotene prevention treatment osteoporosis largely unknown present study aimed elucidate beta carotene affects osteoclast formation bone resorption main methods bone marrow derived monocytes macrophages bmm exposed beta carotene followed evaluation cell viability lactate dehydrogenase ldh release receptor activator nuclear factor kappa ligand rankl induced osteoclastogenesis resorption pits formation key factors nuclear factor kappa kappa mitogen activated protein kinases mapk pathways evaluated western blot bmm cells exposed rankl beta carotene effects beta carotene nuclear factor activated cells cytoplasmic nfatc fos cathepsin ctsk expression also evaluated key findings beta carotene significantly inhibited bmm viability promoted ldh release concentrations decrease rankl induced osteoclastogenesis resorption also observed beta carotene treatment beta carotene attenuated kappa pathway activation rankl effect mapk pathway beta carotene suppressed upregulation nfatc fos rankl significance clarified anti osteoclastogenic role beta carotene mediated kappa signaling elsevier inc rights reserved
article explores people sympathetic talk relation european refugee crisis analysis grounded critical discursive psychology also drew concept affective discursive practice data retrieved phone program irish national radio month period refugee crisis debate height shown speakers deployed elaborate sympathetic repertoires ease described normative emotional response plight asylum seekers speakers found problematic present explicit unambiguous unconditional calls inclusive political solidarity asylum seekers advocating increased asylum provision ireland findings discussed light hostile affective discursive environment towards asylum common sense understanding nation states moral right exclude appears constrain talk position ambivalent paternalism
cognitive rehabilitation developed improve quality life activities daily living mood people cognitive impairment voice people cognitive impairment underrepresented study aimed understand experience people living cognitive impairment well caregivers took part cognitive rehabilitation intervention programme twelve individuals cognitive impairment caregivers participated individual qualitative interviews interview data analysed three steps familiarisation transcripts identification themes interpretation refinement integration themes methodological auditors participants living cognitive impairment caregivers valued comfortable environment friendly caring supportive group leaders taught practical tips strategies participants living cognitive impairment enjoyed socialising like others caregivers benefited learning memory problems sharing challenges caregivers participants living cognitive impairment emphasised benefits relational practical aspects whereas caregivers valued informational emotional support conclusion participants living cognitive impairment caregivers found cognitive rehabilitation group useful
estimated million households united states headed young adults aged percent receive housing assistance funded department housing urban development hud research looks evidence american housing survey stigma associated residence hud assisted housing translated low self efficacy try response becoming economically self sufficient majority young householders percent participated labor force household median incomes percent poverty line forty percent householders less good health disability participated labor force vast majority also parenting small families norm estimated children age lived assisted housing headed young millennials children age living households headed single adult labor force participant logistic regression used find whether statistically significant predictors labor force participation level good health disability respondent educational attainment college statistically significant entire sample additional adult household also increased odds labor force participation household head households headed single adult residence midwest census region depressed labor force participation conclude discovery statistically significant predictors suggests stigma living assisted housing create low self efficacy labor force participation avoided assisted housing reduces burden shelters foster care systems well provides significant safety net workers unable earn living wage
purpose purpose paper propose method reduce non linear distortion transistor input output ports aid distortion contribution analysis dca especially needed internal structure device model complex design methodology approach non linear distortion generated non linear sources inside device model reduced transistor ports lmse fitting techniques simulations ldmos power transistor used compare reduced distortion results actual non linear sources findings shown device models current sources split intermediate nodes cause superficial results distortion contributions calculated superposition contributions individual non linear sources proposed iterative fitting technique works research limitations implications non quasistatic effects transfer functions external terminals internal controlling nodes covered practical implications analysis step toward generic non linear distortion contribution simulation tool would aid designers develop linear analog circuits originality value concept dca fairly new paper makes step represent distortion sources canonical way
developed usgbc leed currently widely adopted credit based green building rating program worldwide buildings graded platinum gold silver certified depending number leed credit points achieved selection leed credits important step leed certification planning application relationships leed credit achievement project factors like budget schedule already studied apart climate factors temperature precipitation also affect selection green building technologies therefore leed credits achieved however study relationships leed credit achievement climate building location lacking paper investigates relationship climate factors leed credits using data mining techniques leed credits achieved local climate conditions leed certified existing building projects collected analyzed setting climate factors variables credit achievements targets classification models built using random forests classification algorithm variable importance credit calculated based contribution classification performance models high auc performance high importance climate factors identified discussed results show climate factors diurnal temperature range notable correlation achievement certain leed credits implications contributions results also discussed elsevier ltd rights reserved
background zarit burden interview zbi originally developed assess level subjective burden caregivers people dementia involvement evaluation questionnaire ieq amongst leading scales assess caregiving consequences severe mental illness aimed compare psychometric properties zbi generic tool ieq specific tool assess consequences caregiving schizophrenia related disorders methods secondary analyses week randomized controlled trial psychoeducational intervention primary caregivers patients schizophrenia schizoaffective disorder psychometric properties internal consistency convergent discriminative validity sensitivity change evaluated zbi ieq results internal consistency good similar scales zbi ieq convergent validity relevant similar domains zbi total score ieq tension least moderate rest domains zbi total score personal strain role strain ieq urging supervision discriminative validity psychological distress depressive symptoms good area curve auc zbi ghq ces respectively auc ieq ghq ces respectively aucs reference criteria differ significantly two scales intervention scales showed significant decrease endpoint values similar standardised effect sizes change zbi ieq conclusions zbi ieq shown satisfactory psychometric properties assess caregiver burden sample provided evidence performance zbi general measure subjective burden
introduction depressive symptoms common patients assessed neuropsychologists symptoms effect cognitive functioning discrepancies patient informant reported depressive symptoms found diagnostic groups raising concerns value assessing depressive symptoms via self report alone study aimed examine relationship discrepancies cognitive functioning heterogeneous outpatient neuropsychological sample method sixty two patients variety diagnoses stroke mild cognitive impairment completed measure depressive symptoms battery neuropsychological tests informants also rated patients depressive symptoms completed measure patients functional abilities results patient informant reports depressive symptoms moderately correlated larger differences patient informant reported symptoms associated poorer verbal learning memory greater functional impairments conclusions moderate level agreement found depressive symptoms consistent past studies using specific neuropsychological patient groups studies clinical non clinical populations results highlight utility collecting informant reports depressive symptoms neuropsychological evaluations
describe superconducting quantum interference device squid readout electronics flux locked loop fll mode without integrator one operational amplifier called single chip readout electronics scre weakly damped niobium squid magnetometer large flux voltage transfer coefficient partial derivative partial derivative phi approximate phi scre results simple squid system characterize system demonstrate applicability magnetocardiography mcg measurements using transient electromagnetic tem method scre simplifies readout scheme also improves system stability bandwidth slew rate difference scre conventional readout scheme preamplifier amplifier integrator also discussed
background given risk opioid misuse among chronic pain patients treated longterm opioid pharmacotherapy non pharmacological treatments needed light hedonic deficits population therapies enhance positive affect may useful purpose study examine effects mindfulness oriented recovery enhancement intervention ecological momentary assessments ema pain positive affective experience determine changes pain affect interaction associated opioid misuse post treatment methods study examined unpublished ema data subset participants previously published rct nct versus support group control across weeks treatment patients completed ema measures pain affect multilevel models generalized estimating equations examined effects treatment momentary pain positive affect generalized linear models examined associations pain affect changes opioid misuse post treatment results patients reported significantly greater improvements momentary pain positive affect patients entire course treatment patients significantly likely exhibit positive affect regulation patients finally improvements positive affect pain course intervention associated reduced risk misusing opioids post treatment conclusion may useful non pharmacological treatment pain hedonic deficits among chronic pain patients risk opioid misuse authors published elsevier ireland ltd
closed loop control glucose homeostasis via subcutaneous insulin infusion continuous glucose monitoring system give better living type diabetic patient paper deals real time implementation internal model control imc subcutaneous insulin infusion model based control applied nonparametric model patient identified real time input output data meal simulation model glucose insulin system type diabetic patient based work dalla man considered model constructed hardware platform acts virtual patient data driven nonparametric model virtual patient identified real time computing volterra kernels kernels solved second order using recursive least squares rls algorithm short memory length validation results identified model output actual output shown good fit simulation real time environments frequency domain kernels used internal model control generate insulin dosage control algorithm developed simulation implemented real time hardware loop dspace platform closed loop system yields good meal disturbance rejection less undershoots settling time profoundly smaller requirement insulin infusion compared earlier reported data elsevier ltd rights reserved
background people parkinson disease often visual perceptual disorders goal study learn develop three dimensional percept depends kinetic depth effect viewer ability spatially integrate time images moving along many trajectories methods sixteen patients healthy matched controls presented stimuli comprised circular region randomly placed dots moved orthographic projections sphere normal kinetic depth effect training stimuli appear opaque rotating ball test stimuli appear rotating transparent ball results whereas controls patients reported seeing training stimuli rotating ball patients significantly less likely report test stimuli appearing ball healthy participants instead seven patients often reported bidirectional stimuli appeared flat conclusions study revealed patients impaired spatio temporal integration bidirectional visual motions mechanism accounting loss well patients deficit needs study driver moving vehicle fixates upon stationary target surroundings bidirectional retinal image motions may occur failure perceive structure moving scenes plausibly suspected contribute adverse events auto accidents published elsevier ltd
note addresses problem optimal filtering class continuous time time varying stochastic systems time variation character considered periodic state space representation optimal filter designed based unique periodic solution suitable lyapunov differential equation periodic stabilizing solution suitable generalized periodic riccati differential equation numerical experiments also added show effectiveness proposed method elsevier rights reserved
sexism stressor many women related host harmful psychosocial outcomes including silencing oneself social relationships present study examined relationships among sexist experiences endorsement traditional feminine gender roles commitment social change self silencing among sample women results revealed recent sexist experiences endorsement traditional feminine gender roles significantly positively predicted self silencing whereas commitment social change significantly negatively predicted self silencing addition lifetime sexist experiences associated greater self silencing women low levels commitment social change women average high levels suggesting buffering effect women less committed social change demonstrated higher levels self silencing sexual objectification experiences less frequent women higher levels commitment social change less likely self silence regardless frequency sexual objectification experiences thus important explore women sexist experiences gender roles attitudes locate women self silencing within sexist sociocultural context moreover fostering commitment social change may promising intervention reducing impact sexist events women self silencing
beaver slide near dalton highway road gradient approximately built hill side year soft spots also commonly named frost boils observed starting late april lasting entire summer frost boils resulted extremely unsafe driving condition frequent accident occurrences conventional repair methods effectively solve issue newly developed geotextile high specific surface area installed selected test section mitigate frost boil issue august type geotextile provide high wettability relatively high suction capillary force consequently able laterally transport water high directional transmissivity unsaturated conditions test results initial years proved effectiveness geotextile alleviate frost heave subsequent thaw weakening issue however still concerns regarding long term performance clogging microscopic drainage channels mechanical failures data collected past years used analyze evaluate effectiveness wicking fabric scanning electron microscope used explore interaction wicking fabric situ soils determine condition fabric years installation american society civil engineers
backgroundthe aim investigate role measured intellectual function framing parents unfit child custody deprivation cases methodgrounded theory used analyse national sample custody deprivation cases iceland resultsthe terminology used evaluate describe intellectual developmental status parents child deprivation custody cases served device define shape unfit parent intellect whether low average even average times acts master narrative informs explains manner perceived parental deficiencies conclusionthe intellectual developmental status served yardstick identifying understanding interpreting unfit parent tool achieve end parents framed language culture using underlying belief set make sense events issues
cyanobacteria oxygenic photosynthetic prokaryotes able assimilate using solar energy water metabolic engineering cyanobacteria suggested possibility direct conversion value added chemicals however engineering cyanobacteria limited due lack various genetic tools expression control multiple genes reconstruct metabolic pathways biochemicals thus developed synebrick vectors synthetic biology platform gene expression synechococcus elongatus pcc model cyanobacterium synebrick chromosomal integration vectors provide three inducible expression systems control gene expression three neutral sites chromosomal integrations using synebrick vector laci regulated gene expression led fold induction eyfp reporter gene isopropyl beta thiogalactopyranoside iptg inducer elongatus pcc tetr regulated gene expression led fold induction gfp gene anhydrotetracycline atc inducer used gene expression decreased due degradation atc light rna polymerase based gene expression resulted efficient expression lower iptg concentration previously developed ptrc promoter library promoters used tunable gene expression summary synebrick vectors developed synthetic biology platform gene expression elongatus pcc results accelerate metabolic engineering biosolar cell factories expressing controlling multiple genes interest
study propose adaptive hybrid artificial bee colony aabc algorithm train anfis unlike standard abc algorithm two new parameters utilized solution search equation arithmetic crossover rate adaptivity coefficient aabc algorithm gains rapid convergence feature usage arithmetic crossover applied two different problem groups performance measured firstly performed numerical benchmark functions results show aabc algorithm efficient standard abc algorithm secondly anfis trained using aabc algorithm identify nonlinear dynamic systems application begins randomly selected initial population average rmse obtained four examples considered anfis training train error values respectively computed also test error values examples respectively found although varies according examples performance increase occurs additionally seen aabc algorithm converges bettter abc algorithm examples obtained results compared neuro fuzzy based approaches commonly used literature seen proposed abc variant efficiently used anfis training elsevier rights reserved
objectives present study aimed investigate relationship airflow limitation severity comorbidities comprehensive health examination methods cross sectional study included men women aged underwent lung function test medical checkups defined forced expiratory volume forced vital capacity logistic regression analysis used assess association severity presence comorbidities results compared normal lung function group subjects higher prevalence lung cancer odd ratio confidence interval men hypertension women diabetes hyperglycemia men women men women adjusting potential confounders men lung cancer mets joint interim statement jis significantly associated moderate severe adjustment women hypertension diabetes hyperglycemia mets jis mets japanese committee criteria mets jccms significantly associated mild adjustment hypertension significantly associated moderate severe adjustment women conclusions significant relationships found severity presence comorbid lung cancer men hypertension women diabetes hyperglycemia mets men women knowledge comorbidities associated widely publicized raise awareness chronic obstructive pulmonary disease copd
view special structure isolated grid backtracking algorithm widely used black start path optimization defect time consuming blind optimizing paper minimal spanning tree integrated backtracking algorithm proposed realize path optimization black start firstly paper builds weight factors transmission line unit identify significant nodes optimal black start topology built maximum weight factors transmission line backtracking algorithm introduced calculate specific black start path optimal tree topology target maximize weight factor path optimization algorithm effectively reduce path search space high robustness finally new england unit bus system used example verify effectiveness proposed algorithm
paper edit detection method forensic audio analysis proposed develops improves previous method changes signal processing chain novel detection criterion original method electrical network frequency enf analysis central novel edit detector allows monitoring anomalous variations enf related audio edit events working unsupervised manner edit detector compares extent enf variations centered nominal frequency variable threshold defines upper limit normal variations observed unedited signals enf variations caused edits signal likely exceed threshold providing mechanism detection proposed method evaluated qualitative quantitative terms via two distinct annotated databases results reported originally noisy database signals well versions degraded controlled conditions comparative performance evaluation terms equal error rate eer detection reveals one tested databases improvement eer achieved respectively original new edit detection method signals amplitude clipped corrupted broadband background noise performance figures novel method follow profile original method
deployment internet things embedded systems using microcontroller nowadays threats network incorporating security measure systems highly required unfortunately microcontrollers powerful enough execute standard security programs need light weight high speed secure cryptographic libraries paper port nacl cryptographic library arm cortex microcontroller put much effort fast secure implementation evaluation show implementation achieves times faster avr nacl result reduce half code size
objective study examine whether mother father closest grandparent involvement associated south african adolescents mental health internalizing externalizing problems prosocial behavior substance use sample grade grade learners cape town age years completed structured survey participants female identified colored mixed race hierarchical multiple regression analyses controlling age sex socioeconomic status indicated mother father involvement negatively associated adolescents internalizing externalizing problems whereas mother closest grandparent involvement positively associated prosocial behavior hierarchical logistic regression analyses revealed parent involvement negatively associated past month cigarette use past month alcohol past year marijuana use findings suggest importance considering parents grandparents interventions promote adolescent mental health
indoor smart grids proper operation building environmental systems essential energy efficiency automatic detection classification abnormal conditions important application computational intelligence tools building environmental systems include building automation system bas heating ventilating air conditioning hvac loads used develop automatic building diagnostic tools health monitoring fault detection diagnostics novel health monitoring system hms variable air volume vav unit developed using fuzzy logic detect abnormal operating conditions generate fault signatures various fault types artificial neural network classification technique applied fault signatures classify fault type hms tested simulated data actual bas data system created demonstrated recognize faults accurately classify various fault signatures test faults interest
flux switching permanent magnet machines provide many advantages due superior behavior associated sinusoidal back emf low torque ripple topologies featuring stator teeth rotor poles favored however follows given mechanical rotor speed required electric fundamental frequency ten times conventional two pole machine imposing challenging requirements set power electronics paper fspm machine design investigated since lowest feasible slot pole combination conventional fspm machine design viable design due presence dominant second order harmonic component flux linkage high torque ripple thus split magnet design introduced allows achieving better performance significantly reducing second harmonic component multi objective optimization scenario carried utilizing evolutionary algorithm performing massively distributed finite element simulations computer cluster selected machine design particular torque characteristics analyzed achieved results reveal considering split magnet topologies low slot pole fspm machine configurations unlock potential high speed operation
study examined association psychiatric symptoms diabetes knowledge among adults serious mental illness smi type diabetes relationship glucose control alc also examined hierarchical linear regression greater negative symptom severity lower cognitive functioning predicted lower though cognitive functioning superseded negative symptom severity analyzed simultaneously pearson correlation showed significant relationship although symptom severity cognitive functioning related among population cognitive functioning maybe particularly important published elsevier inc
investigated whether donepezil cholinesterase inhibitor used treat sleep disturbances patients dementia lewy bodies dlb sleep disturbances evaluated sleep disturbances item neuropsychiatric inventory npi actigraph dlb patients normal elderly control subjects presence absence nine kinds sleep symptoms dream enactment also evaluated dlb patients dlb patients given day donepezil weeks evaluated eight dlb patients sleep disturbances taking donepezil actigraphy data indicated average activity count per minute sleep aac reflects body activity night significantly higher total sleep time significantly longer dlb patients subjects npi sleep disturbances score significantly improved number dlb patients sleep disturbances decreased taking donepezil actigraphy results indicate sum wake epochs within sleep period reflects degree fragmented sleep aac decreased dlb patients donepezil treatment results indicate donepezil treatment reduced sleep disturbances dlb patients
paper describes development implantable insertable drug delivery systems idds early stage current stage gives detailed summary non degradable biodegradable systems applications different areas vascular disease treatment birth control cancer treatment eye disease treatment also describes development various implantable pump systems atypical idds challenges future idds elsevier rights reserved
objective physical activity especially moderate vigorous intensity could protect older adults cognitive impairment however literature based self reported limited recall bias light popular among older adults paucity objective longitudinal data considered relationship light cognitive ability examined higher level objectively measured light independent moderate vigorous physical activity mvpa prospectively associated better cognitive ability older adults methods longitudinal study months including community dwelling older adults across regions taiwan undertaken cognitive ability obtained using chinese version ascertain dementia item questionnaire light mvpa captured days accelerometer positioned waist multivariable negative binomial regression adjusted confounders undertaken results participants years male attended follow higher light independent mvpa associated reduced rate decline cognitive ability rate ratio mvpa also associated reduced decline cognitive ability rate ratio light protective cognitive ability sensitivity analyses removing participants activities daily living difficulties depressive symptoms cognitive impairment baseline conclusion data suggest light may offer protective influence future cognitive ability community dwelling older adults promotion light may valuable means maintain cognitive ability older age elsevier inc rights reserved
paper deals vibration control means piezoelectric patches shunted electrical impedances made resistance negative capacitance paper analyses possible layouts negative capacitance built shows common mathematical description possible allows closed formulations found order optimise electrical network mono multi mode control general analytical formulations obtained estimate performance shunt terms vibration reduction particular highlighted main effect negative capacitance artificially enhance electromechanical coupling factor basis performance estimation stability issues relating use negative capacitances especially addressed using refined models piezoelectric patch capacitance furthermore new circuit based couple negative capacitances proposed tested showing better performances provided usual layouts single negative capacitance finally guidelines analytical formulations deal practical implementation negative capacitance circuits provided
backgroundthe nhs intends move current read code system international detailed systematized nomenclature medicine clinical terms snomed facilitate clinically appropriate coding conditions associated risk factors outcomes given concerns coding behaviour general practitioners sought study current coding patterns allergies identify lessons future migration snomed methodsdata primary care consultations patients one potentially allergic diseases anaphylaxis angioedema asthma conjunctivitis drug allergies eczema food allergy rhinitis urticaria venom allergy probable allergic disorders scottish primary care clinical informatics unit research pcciu database descriptively analysed visualized understand read code usage patterns resultswe identified read codes allergic diseases codes used consultations codes never used half usage quality outcomes framework codes asthma despite detailed codes available allergic triggers infrequently used conclusionsthis analysis read codes use suggests introduction detailed snomed isolation improve quality allergy coding scottish primary care introduction snomed accompanied initiatives aimed improving coding quality definition terms codes availability terminology browsers recommended list codes mechanisms incentivize detailed coding condition underlying allergic trigger
quantitative evaluation shear threshold tinctorius cell growth vital bioreactor system design optimization scaled industrial cultivation present research focused investigating effects shear force tinctorius cell growth computational fluid dynamic cfd analysis shaken flasks results revealed specific cell growth rates greatly inhibited shear force increased recovery viability aggregation diameter normal levels could implemented day adaptation large fluctuations physiological state correlation analysis shear force tinctorius growth rate threshold value identified average maximum shear stress approximately according influence cell growth quantitative data shear effects facilitate design industrial processes lead rational scale industrial tinctorius cultivation elsevier rights reserved
tungsten currently deemed promising plasma facing material pfm future power plant demo case accident air get contact pfms air ingress temperature pfms rise degrees due nuclear decay heat case damaged coolant supply heated neutron activated tungsten forms volatile radioactive oxide mobilized atmosphere new self passivating smart alloys adjust properties environment plasma operation preferential sputtering lighter alloying elements leave almost pure tungsten surface facing plasma accident alloying elements bulk forming oxides thus protecting tungsten mobilization good plasma performance suppression oxidation required smart alloys bulk tungsten chroimum titanium alloys exposed together pure tungsten samples steady state deuterium plasma identical conditions linear plasma device psi temperature samples similar degrees degrees energy impinging ions matching well conditions expected first wall demo weight loss measurements demonstrated similar mass decrease smart alloys pure tungsten samples oxidation exposed samples proven effect plasma exposure oxidation resistance alloy demonstrated advantageous fold lower mass gain due oxidation pure tungsten new yttrium containing thin film systems demonstrating superior performance comparison systems pure oxidation rate constant thin film times less pure tungsten however detected reactivity bulk smart alloy humid atmosphere calling improvement
differences people beliefs substantially impact interpretation series events functional mri study manipulated subjects beliefs leading two groups subjects interpret narrative different ways found responses higher order brain areas including default mode network language areas subsets mirror neuron system tended similar among people shared interpretation different people opposing interpretation furthermore difference neural responses two groups moment correlated magnitude difference interpretation narrative study demonstrates brain responses event tend cluster together among people share views
number measures increase quality data recorded improved balzers eldigraph gas phase electron diffractometer discussed beam stop decoupled sector enabling recording current primary beam scattered electrons experiment different beam stops tested use present setup modifications nozzle tip earlier described medium temperature nozzle reported measures lead reduced exposure times reduced amount sample necessary complete data collection
given facts vast area earth covered water average depth oceans issue unknowns beneath water surface challenging questionable one decades since remotely operated vehicles well untethered underwater robots appeared elevated level complex engineering category underwater robots mimic fish aquatic creatures open new horizons article imitating body shape kinematics swimming mechanism batoid fish dasyatidae vessel designed swim acceptable speed limited amount power hull shape based cardioid curve drag force calculated using fundamentals fluid mechanics propulsion robot fish two wings starboard port undulating backward thrust approximated versus shaft speed finally power swimming design speed evaluated compared available data similar orders magnitude
background emergency medical technicians emts paramedics serve primary providers urgent medical care integral components disaster response risk fatal nonfatal injuries activities objectives describe fatal nonfatal injuries occurring emts paramedics methods analyzed data bureau labor statistics bls census fatal occupational injuries cfoi occupational supplement national electronic injury surveillance system neiss work period results identified confidence interval nonfatal injuries treated emergency departments fatal injuries period fatalities related motor vehicle incidents aircraft crashes among compensated emts paramedics rate fatal injuries per full time equivalents nonfatal injuries primarily associated stress part body motion overexertion among nonfatal injuries common diagnosis sprains strains conclusions emergency medical technicians paramedics higher fatal injury rates compared workers reduce fatalities targeted efforts made prevent ground air transportation incidents reducing nonfatal injuries may accomplished developing evaluating interventions prevent bodily stress overexertion injuries
delayed maturation adolescent prefrontal cortex may render particularly vulnerable insults including associated drugs abuse using rat model binge alcohol exposure present study examined effect adolescent intermittent ethanol aie exposure postnatal days aminobutyric acid gaba ergic neurotransmission prelimbic cortex control rats patch clamp electrophysiology acute slices obtained different postnatal ages revealed developmental increase gaba receptor mediated tonic current layer pyramidal neurons change layers iii measured adult slices aie exposed rats amplitude tonic current significantly reduced compared controls tested postnatal days aie induced reduction tonic current found reflect attenuation currents mediated delta subunit containing receptors consistent facilitation tonic current bath application either ethanol allopregnanolone attenuated slices aie exposed adult rats compared control rats however expression facilitation percent amplitude total current mediated delta gaba receptors revealed aie alter sensitivity either agonist lastly immunohistochemistry western blot analysis revealed change expression delta gaba subunits surface expression taken together studies reveal aie exposure results persistent deficits delta gaba tonic currents adult prelimbic cortex may contribute deficits decision making behavioral control adulthood
background recent study found nuvaring vaginal contraceptive ring containing ethinyl estradiol etonogestrel times increased relative risk thrombotic stroke compared nonuse objective studied case series patients well prior published case reports clarify clinical radiological prognostic features methods medical records imaging cases initially systematically reviewed consultation class action lawsuit one case seen personally outside litigation cases entered database detailing clinical radiological prognostic features well potential risk factors literature search identified additional cases results average age stroke years average duration nuvaring use prior stroke months arterial stroke occurred hemorrhagic venous sinus thrombosis present initial imaging hemorrhagic common presenting symptom headache motor weakness hypercoagulable condition present history hypercoagulable disease first degree relative mortality fully recovered discharged rehabilitation conclusions largest case series nuvaring associated stroke date approximately half strokes venous half arterial stroke typically occurred within first year use soon weeks nuvaring initiation
herein present retrospective study concerning provision school meals children food allergies avoid specially selected menus seem essential improve day day quality life children families eighty two children aged years presenting food allergies primarily peanuts cashew nuts partook school meals without specially prepared menus part individualised meal project projet accueil individualise paid following study concerning reading menus conducted help school doctors within region well various bodies responsible school meals based advances knowledge treatment food allergies recent years felt essential able provide personalised school meal service taking account serious nature french dietary habits available data concerning allergic accidents associated school meals elsevier masson sas rights reserved
conventional flight control design autopilot autothrottle systems usually considered separately resulting complex system inefficient integration functions therefore concept aircraft energy control brought solve problem coordinated control using elevator throttle goal study develop optimal energy control system oecs based concept optimal energy fixed wing unmanned aerial vehicles uavs energy aircraft characterized two parameters specific energy distribution rate driven elevator total specific energy rate driven throttle study system identification method employed obtain energy model small uav proposed approach consists energy distribution loop total energy loop energy distribution loop designed based linear quadratic gaussian lqg regulator responsible regulating specific energy distribution rate zero hand total energy loop based simple gain scheduling method responsible driving error total specific energy rate zero implementation oecs successfully validated hard loop hil simulation applied uav
high strain rate loading magnesium alloy carried radial collapse thick walled cylinder technology evolution precipitates solution treated peak aged magnesium alloy high strain rate deformation studied transmission electron microscopy tem first time large number elongated rod like phase precipitated solution treated sample impacting rod like phases peak aged sample experienced shortening thinning finally transformed spherical like phases namely rod like phases preliminarily dissolved matrix based thermodynamics kinetics analyses high strain rate high density dislocation high shear stress adiabatic temperature rise induced explosive impact process make possible precipitates precipitate dissolve preliminarily within elsevier rights reserved
known objectivethe prevalence diabetic nephropathy continues rise remains strong predictor morbidity mortality diabetic patients patients diagnosed diabetic nephropathy actively excluded trials involving diabetic medications important understand prescription patterns subset patients diabetes methodsusing ims health national disease therapeutic index analysed medication prescription patterns six classes medications among patients years older diabetic nephropathy resultsannual office visits increased confidence interval declined sulfonylureas dipeptidyl peptidase inhibitors dpp inhibitors frequently used four classes diabetic medications included study dpp inhibitors use increased gradually used treatment visits last quarter across years angiotensin converting enzyme inhibitors angiotensin receptor blockers aceis arbs prescribed majority treatment visits peaks however periods utilization antihypertensives low new conclusionssignificant increases occurred uptake new diabetic medications dpp inhibitors sglt inhibitors utilization aceis arbs compared findings reported studies increased complexity treatment patients diabetic nephropathy improved continued used medications may beneficial improving patient outcomes
design implementation low cost grid connected kva solar photovoltaic system proposed paper since inverter major component system inverter used paper reduces total cost system order eliminate massive transformer system connected grid igbt switches addition injection active power grid inverter compensate reactive power reduce harmonics nonlinear loads tmsf dsp processor used effective control inverter various features processor enable implementation necessary control algorithms first step system simulated evaluated matlab simulink second step hardware circuits designed implemented based simulation results operation system evaluated balanced unbalanced linear nonlinear loads proves accuracy efficiency
examination photographic processes century present digital age effective means intellectually engage nonscience majors science laboratory course nonscience majors exploring processes described article ionic covalent compounds oxidation reduction reactions precipitation reactions complex ion formation major themes course important themes light color generation color photographic images experiments comprise laboratory component nine involve making photographic prints nearly involve hand coated paper nearly required supplies found ordinary general chemistry laboratory experiments keep chemistry processes foreground letting students exercise creativity figures article exemplify quality images students achieve course enriched intertwined histories chemistry photography work contemporary photographers judging level student participation engagement remains high beginning end course
paper proposes mapping two product quality software processes models used industry certics brazilian national model cmmi dev international model focus mapping technological development competence area certics directs response key question whether software result technological development country results mapping presented step step well mapping review cooperation one expert certics cmmi dev models thus paper aims correlate structures two models order facilitate reduce implementation time costs stimulate execution multi model implementations software development enterprises
membrane based silencer using dielectric elastomer absorbers deas developed explored present study dielectric elastomer soft smart material used fabricate actuator characteristic lightweight high elastic energy density large deformation external direct current alternating current voltages typical acoustic performances membrane based silencer experimentally identified using transmission loss duct acoustic measurement system found resonance peaks membrane based silencer could controlled applying different external voltages maximum resonance frequency shift resonance peaks achieved indicated membrane based silencer could adjusted absorb target noise without addition mechanical part furthermore resonance shift multiple resonances mechanisms using deas proposed discussed aiming achieve multi peaks noise reduction present results also provide insight appropriateness absorber possible use acoustic treatment replace traditional acoustic treatment noise reduction technology elsevier ltd rights reserved
rgb human action recognition active research topic computer vision robotics paper action recognition method combines gradient information sparse coding proposed first leverage depth gradient information distance skeleton joints extract coarse depth skeleton feature sparse coding max pooling combined refine coarse feature finally random decision forests rdf utilized perform action recognition experimental results three public datasets show superior performance method
lhcb detector upgraded next lhc shutdown tracker system major overhaul components replaced new technologies order cope increased hit occupancy radiation environment describe detector made scintillating fibers read silicon photomultipliers sipm view application upgrade technology shown achieve high efficiency spatial resolution integration within lhcb experiment presents new challenges article gives overview status low power asic scintillating fibres tracker pacific chip implemented cmos technology pacific chip channel asic connected sipm without need external component includes analog signal processing digitization first stage current conveyor followed tunable fast shaper approximate gated integrator digitization performed using threshold non linear flash adc operating mhz pacific chip ability cope different sipm suppliers power consumption per channel radiation tolerant lastly simulation test results show proper read sipms pacific chip
background abnormally invasive placenta aip placenta accreta considered numerous adverse maternal fetal neonatal complications detailed study characterize prevalence aip among deliveries mainland china objectives aimed fill gap obtained overall regional estimates aip prevalence via systematic review meta analysis methods systematic review meta analysis totally performed following meta analysis observational studies epidemiology guidelines systematic reviews observational studies preferred reporting items systematic reviews meta analysis statement reporting systematic reviews meta analysis results total articles including included studies focused placenta increta articles none placenta percreta meta analysis overall prevalence aip confidence interval heterogeneous set studies subgroup prevalence respectively stratified analyses found prevalence similar north south lower central inlanders lower prevalence living coastal areas time goes prevalence present higher higher different prevalence also found different maternal age groups conclusions first systematic review meta analysis found prevalence differed among different geographic areas maternal age groups results would useful design abnormally invasive placenta planning implementation adequate health care systems treatment programs mainland china
objectivecognitive remediation therapy crt specialized treatment approach targeting cognitive weaknesses anorexia nervosa regarding follow effects crt studies available adolescents data methodsforty eight adolescents assigned receive either crt treatment usual tau tau alone assessments performed baseline compared assessments month follow outcome measures set shifting central coherence eating disorder general psychopathology resultsthe completion rate higher crt compared tau significant differences neuropsychological clinical variables changes body mass index percentile showed trend towards significance crt dropout analyses revealed significant predictors conclusionsresults provide first insight follow assessments crt adolescent randomized controlled studies needed clarify long term effects crt copyright john wiley sons ltd eating disorders association
seamless secure handover always one important design goals cellular networks handover scheme long term evolution lte wireless networks complex due presence two possible different types base stations lte communication systems normal base station referred enodeb enb increases level complexity system fact kind base stations namely home enodeb henb directly communicate enb lte networks handover scenarios involving henb could result complicated handover procedure besides since key chains used handover processes found lack backward security therefore order handle handover involving henb efficiently security provisioning paper proxy signature based handover scheme proposed proposed scheme works based elliptic curve cryptography ecc algorithm makes computational cost handover process smaller compared handover schemes
background knowledge living childhood cancer trajectory sparse aim aim study follow young children health functioning everyday life cancer trajectory methods data gathered longitudinally group young children parents connected pediatric oncology unit sweden international classification functioning disability health children youth structure used identify difficulties health functioning everyday life interview questionnaire data descriptive statistical analysis performed show patterns difficulty year period diagnosis results difficulties experienced children declined changed time increase difficulties personal interactions others access support health care professionals seen years diagnosis start treatment similar patterns seen within individual children trajectories relation diagnosis individual patterns seen child conclusions clinical implications health care professionals need plan ongoing contact school services information support pathways beyond treatment period person centered philosophy care required throughout cancer trajectory
purpose purpose paper evaluate online teachable moment intervention promote healthy eating overweight food intolerance symptoms design methodology approach study involves factorial design two conditions group weight loss food intolerance condition intervention control intervention aimed generate teachable moment providing knowledge regarding relationship food problem overweight food intolerance focussing negative aspects problem creating behavioural model encouraging hope reinvention participants receiving intervention completed measures dietary behaviour either weight food intolerance symptoms receiving intervention one month later control participants provided measures receive intervention findings significant reductions weight food intolerance symptoms however compared control participants participants intervention conditions reported greater intentions eat healthily improved healthy eating behaviour time following intention treat explanatory analysis practical implications encouraging individuals perceive everyday situation time change adopt healthier behaviour early may prevent future diet related medical events benefits individual health care costs originality value quick easy administer online teachable moment intervention improves dietary behaviour minimally adapted suit individuals differing health needs
empirical evidence suggests increased production false memories advancing age activation monitoring theory proposes strategic monitoring processes influence probability false recall drm paradigm present study examined hypothesis low level inhibition may impair efficient use monitoring processes information retrieval thus increase production false memories aging accordingly conducted study older adults low high levels inhibition performed standard drm task inclusion drm task disables monitoring processes results indicated low inhibitory capacities associated fewer correct recalls increased production critical lures false memories suggesting difficulties using monitoring processes time retrieval findings also showed relationship age production critical lures standard drm task mediated inhibition results interpreted suggesting inhibitory abilities may partly linked impairment monitoring processes elderly
processing results measurements operational amplifier parameters using virtual instrumentations technology labview development environment considered method automated processing operational amplifier parameters measurements results proposed formulas operational amplifier spice model parameters calculations given
tocilizumab humanized anti interleukin receptor antibody treating rheumatoid arthritis pharmacokinetic pharmacodynamic analysis performed week double blind parts randomized controlled trials summacta brevacta summacta compared subcutaneous tocilizumab every week intravenous tocilizumab every weeks whereas brevacta evaluated subcutaneous tocilizumab every weeks versus placebo addition noncompartmental analysis compartment population pharmacokinetic model first order absorption subcutaneous linear michaelis menten elimination used mean observed steady state predose tocilizumab concentrations week subcutaneous every week every week dosing respectively intravenous dosing population model body weight important covariate affecting clearance volume distribution mean population predicted predose concentration patients subcutaneous tocilizumab every week every weeks efficacy lowest subcutaneous every week dosing patients reflecting lower exposure subcutaneous every week regimen recommended patients pharmacodynamic responses comparable every week subcutaneous every week intravenous regimens less pronounced every week subcutaneous regimen trend observed increased adverse events increasing tocilizumab exposure results analysis consistent noninferiority efficacy every week subcutaneous regimen every week intravenous regimen superiority every week subcutaneous regimen placebo results support label recommendations subcutaneous dosing tocilizumab rheumatoid arthritis patients
little known distinct reproductive biology armadillos studies investigated armadillo spermatogenesis data available euphractus sexcinctus dasypus novemcinctus present study analysed male germ cell differentiation large hairy armadillo chaetophractus villosus throughout year describing cycle seminiferous epithelium made eight different stages evaluation testis body mass ratio analysis architecture seminiferous epithelium frequency defective seminiferous tubules allowed identification temporal interruption spermatogenesis period mid may july mid end autumn correlation low testosterone levels overall results suggest spermatogenesis seasonal villosus
although recent scholarship focuses increasing significance processes standardization contemporary social life much less attention given standardization impacts intimate life intimate standards made meaningful interaction article draws participant observation online transgender groups examine medical standardization transsexuality known wrong body model impacts way users understand communicate gendered self show rather simply adopting wrong body model participants use language logic ironic playful ways carve spaces ways knowing self feel authentically case shows intimate standards become part language self ways may unexpected
responding difficulties implementing meta heuristics hybridization paper introduces set scripting language constructs rapid algorithm design development focusing two well known meta heuristics namely particle swarm optimization pso genetic algorithm additionally pso hybrids embedded dynamic parameterization paper compiler specification codes developing scripting language constructs described based several algorithms pso hybrids developed scripting language constructs line codes loc measured order test easiness programming language results show across algorithms scripting language anticipated enable easy programming presented less loc compared java programming language
allowing rats extended access cocaine self administration thought recapitulate several key aspects cocaine addiction humans understanding mechanisms underlie drug induced neuroadaptations persist brain protracted periods abstinence crucial towards goal developing therapeutic interventions disease state employed whole cell voltage clamp extracellular recording technique assess changes neurotransmission long term potentiation ltp stratum radiatum region using rat ventral hippocampal slice preparation rats allowed self administer cocaine daily including long access hours sessions exhibited increase amino hydroxy methyl isoxazolepropionic acid ampa methyl aspartate current ratio enhanced excitatory transmission following weeks abstinence inhibitory transmission also significantly decreased long access animals ampa methyl aspartate ratio measured absence gabaergic blockers greatly enhanced also observed significant reduction ltp magnitude evoked long access cocaine rats findings suggest presence synergistic effects enhanced ampa diminished gamma aminobutyric acid neurotransmission physiological conditions region cocaine taking animals supporting conclusion persisting enhancement ampa mediated transmission inhibition gamma aminobutyric acid mediated transmission promoted chronic state potentiation partially occluded ltp increased output ventral hippocampus limbic areas would among drug induced neuroadaptations persist following abstinence cocaine self administration therefore may contribute disease state addiction
backgroundcontrolling prekallikrein activation inhibitor cinh represents essential mechanism angioedema patient protection cinh function plasma usually measured based residual activity protease involved pathological process hereby proposed alternative enzymatic measurement cinh function based contact phase activation correlation angioedema diagnostic requirements methodsthe contact phase reconstituted using purified components cinh standard plasma sample kinetics amidase activity monitored using pro phe arg pna independently alpha macroglobulin prevented interference possible high plasma kininogenase activity preincubating samples protease inhibitor receiver operating characteristics roc used calculate assay diagnostic performance resultsthe calibration curve built using cinh standard threshold limit pmol cinh function quantified sample reference interval established based healthy individuals men median women median median values female donors lower others due estrogen yet cinh function remained within reference interval roc curve calculation provided following optimum diagnostic cutoff values women area curve auc sensitivity specificity men auc sensitivity specificity conclusionthe performance outcome provided features suitable angioedema diagnostic follow established means kinin formation process assay preferred method based protease target
network security encryption decryption technology complete application layer technology bring computing resources waste energy particularly two resources limited wireless communication system problem use large scale multi antenna technology using beamforming algorithm power spectrum limited conditions maximize mutual information system security simulation results demonstrate ability secure transmission algorithms effectively improve system
million people displaced result conflict exposure lead psychiatric sequelae aims study provide estimates pre emigration trauma post migration stress psychological sequelae immigrants refugees predominantly sub saharan africa immigrated sweden also examined predictors psychiatric sequelae well acculturation within host country total refugees immigrants enrolled using stratified quota sampling battery questionnaires including harvard trauma questionnaire post migration living difficulties scale cultural lifestyle questionnaire hopkins checklist administered descriptive statistics chi square analyses pearson correlations analysis variance logistic linear regression performed test aims study eighty nine percent participants reported least one traumatic experience prior emigration forty seven percent refugees reported clinically significant ptsd reported clinically significant depressive symptoms males reported significantly greater number traumatic events post migration stress females particularly financial discrimination healthcare subscales females reported higher prevalence depressive symptoms compared males shorter duration sweden reported higher rates ptsd greater number traumatic events found significantly associated severity ptsd symptoms using regression analysis variances associated anxiety depression respectively explained gender education religion ptsd post migration stress sixty nine percent variance associated ptsd included education number traumatic events depressive symptoms post migration stress forty seven percent variance acculturation accounted model included age education duration sweden anxiety depression post migration stress predictors also significant employment status exception depressive symptoms multidimensional interventions provide treatments improve psychiatric symptoms combination advocacy support reduce stress financial access health care recommended focus intervention may also modified based gender participants
associations white matter pathway abnormalities antisocial personality disorder adults well replicated evidence association white matter abnormalities conduct disorder adolescents study white matter maturation using diffusion tensor imaging dti examined children aged years selected vary widely numbers symptoms results replicated age related increases fractional anisotropy found previous studies significant association number symptoms symptoms found significantly associated greater axial radial diffusivity broad range white matter tracts particularly girls complementary analyses similar significant differences axial radial diffusivity children met diagnostic criteria healthy children symptoms particularly girls brain structural abnormalities may contribute emergence childhood perhaps playing greater role girls elsevier ireland ltd rights reserved
mri synovitis relies use gadolinium based contrast agent diffusion weighted mri dwi visualises thickened synovium limited use presence joint effusion investigate feasibility diagnostic accuracy diffusion weighted mri intravoxel incoherent motion ivim diagnosing synovitis knee joint children juvenile idiopathic arthritis twelve consecutive children confirmed suspected juvenile idiopathic arthritis girls median age years underwent mri contrast enhanced weighted imaging dwi read segmented multi shot dwi acquired values calculated ivim parameters perfusion fraction tissue diffusion coefficient diffusion weighted images parameter maps post contrast weighted images retrospectively assessed two independent readers synovitis using juvenile arthritis mri scoring system seven children showed synovial hypertrophy contrast enhanced imaging diagnostic ratings synovitis dwi maps fully consistent contrast enhanced imaging diagnostic reference two children equivocal low confidence assessments dwi median synovitis effusion muscle popliteal lymph nodes diagnostic confidence higher based maps three children lower one child compared dwi dwi ivim reliably visualises synovitis knee joint perfusion fraction maps differentiate thickened synovium joint effusion hence increase diagnostic confidence
static diagrams prevalent artifact used visualizing component connector architectures supporting software architecture learning use artifacts exhibits fundamental disconnect dynamic nature software systems deemphasizes importance architectural interactions focus static structure support high degree learner engagement paper presents work addressing challenges developing runtime visualization techniques better support learning use visual vocabularies leverage insights computer graphics human perception also present evaluative data drawn user studies associated insights provide positive indicators work effective supporting target learning outcomes
objective present case distal tibiofibular sprain rare injury among ubiquitous lateral ligament sprains ankle clinical features old recreational hockey player treated ankle sprain demonstrating increased translation drawer test pain inversion stress also pain external rotation dorsiflexion rays demonstrated fractures intervention outcome conventional protocol protect rest ice compress elevate price employed common lateral ankle sprains followed early mobilization proprioceptive training tilt board recovery prolonged ossification ankle syndesmosis seen follow radiographs conclusion management implications outcome sequelae uncommon syndesmotic sprain severe commonly seen lateral ankle sprain simple physical examination procedures useful identifying syndesmotic sprains routine examination injured ankle emphasized include dorsiflexion external rotation stress squeeze test
employing state art automated design optimization techniques field evolutionary computation engineers able discover electrical machine designs highly competitive respect several objectives like efficiency material costs torque ripple others apart pareto optimal good electrical machine design must also quite robust must sensitive regard design parameters would severely increase manufacturing costs make physical machine exhibit characteristics different computer simulation model even using modern parallel distributed computing environment carrying global tolerance analysis electrical machine design extremely challenging number evaluations must performed evaluation requires time intensive non linear finite element simulations present research describe global surrogate models ensembles fast train artificial neural networks created order speed multi objective evolutionary search easily reused perform fast tolerance analysis optimized designs using two industrial optimization scenarios show surrogate based approach offer valuable insights regarding local global sensitivities considered objectives fraction computational cost required based strategy encouraged good performance individual designs also used surrogate approach track average sensitivity pareto front entire optimization procedure results indicate generalized increase sensitivity runs used evolutionary algorithms enter stage discover electrical drive designs trade robustness quality
background little known associations preschoolers health behaviors later psychosocial wellbeing study investigates association year old children physical activity electronic media use later social emotional skills years methods data collected healthy active preschool primary years happy study metropolitan melbourne participants random subsample children follow physical activity objectively measured using actigraph gtm accelerometers electronic media use television viewing sedentary electronic games active electronic games parent proxy reported social emotional skills child reported using bar emotional quotient inventory youth version regression analyses controlled sex clustering center recruitment accelerometer wear time physical activity analyses results sedentary electronic games positively associated intrapersonal stress management skills total emotional quotient computer internet use inversely associated interpersonal positively associated stress management skills conclusions findings suggest physical activity associated children psychosocial health types electronic media use future research investigate contexts preschoolers participate behaviors potential causal mechanisms associations
study objective long acting reversible contraceptives including etonogestrel implants top tier contraceptives adolescents yet remained underutilized study aimed assess awareness attitudes toward etonogestrel implants among adolescent young adult women design main outcome measures cross sectional study distributed original self administered survey convenience sample anonymous subjects survey assessed demographic information pregnancy sexual history general contraceptive preferences awareness implants subjects read brief description implants completing section assessing attitudes toward used chi square test analyses identify factors associated awareness positive attitudes toward implants setting participants women aged attending birth control education group adolescent health center new york city results participants heard etonogestrel implants reported positive attitudes toward implants positive attitudes associated preferences birth control convenience privacy neutral negative attitudes associated preference birth control maintained menstrual regularity experienced least unintended pregnancy age race education associated participants attitudes toward implants conclusions women value convenience privacy likely report positive attitudes toward implants thus may represent especially receptive candidates
study presents class fractional order models system identification thermal dynamics buildings fractional order dynamics found inherent nature heat transfer problems thus instinctive use fractional order models describe overall thermal dynamics building besides fractional time series modeling known long memory effect capability representing high order complicated models lower order compact forms reduction model parameters relieve computational overhead system identification procedure particular significance model based predictive control building energy efficiency particular fractional order autoregressive model exogenous input farx formulated corresponding parameter estimation using least squares technique also provided furthermore farx model validated using simulation data detailed model built via iessoftware compared prediction using traditional arx model found farx model reduce computational time largely retaining prediction accuracy authors published elsevier
numerical model used investigate mechanical behaviour granular embankments reinforced geosynthetics areas prone subsidence overcome shortcomings current design methods ability numerical model consider load transfer mechanisms deflection geosynthetic established comparison experimental data testing two numerical processes demonstrated cavity opening modes great influence shape load distribution transmitted geosynthetic sheet cavity expansion mechanisms soil approximate conical load distribution seems well adapted considering progressive cavity diameter opening process whereas inverted load distribution seems suitable gradual settlement process cases intensity load transfer mechanism approached terzaghi formulation using appropriate value ratio horizontal vertical stresses finally recommendations based experimental numerical results proposed promote better design structures elsevier ltd rights reserved
article preparation befor job blind pipe fixed waterproof plate laying geotextile analysis waterproof board laid preparatory work waterproof board laid process related indicators control offer reference construction tunnel
recent years distributed zero day attacks emerged one serious security threats incomplete knowledge information stand alone intrusion detection system ids one main reasons success attacks collaborative ids cids one solution address problem idss framework share knowledge consult access larger number detection libraries ids configuration along possibility cooperation participants collaborative system lead improved overall performance however larger number libraries collaborative activities increase resource consumption communication overhead may turn reduce system performance large number papers literature utilized game theory describe optimal configuration standalone networked idss paper works extended interactions attackers idss cids framework modeled nonzero sum stochastic game regard solution concept stationary nash equilibrium applied game describe optimal configuration ids cids expected behavior attackers
paper presents new approach based combination particle swarm optimization gradient method solve unit commitment problem proposed strategy optimizes combination production units operations determines appropriate operational scheduling production units satisfy expected consumption well specific duration production unit conducted constraints render problem complex combinatorial nonlinear resolution problem conducted several constraints take account minimum minimum time constraints start cost spinning reserve adopted approach applied ieee electrical network buses containing production units simulation results clearly proven gradient pso method competent optimizing problem comparison existing methods
fault detection induction machines commonly realized motor current signature analysis case wound rotor induction machine rotor faults amplitude inverse sequence harmonic component rotor current space vector monitored order sense variation however motor current signature analysis limited drawbacks fact transient operating conditions efficient fast fourier transform made since slip frequency vary amplitude harmonic component paper new technique based square current space vector signature analysis scssa proposed rotor fault detection wound rotor induction machines operating time varying conditions performance proposed approach confirmed simulation experimental results proposed technique easily embedded digital control system modern wind power plants
paper presents analysis security performance evaluation hardware architecture redundant bit security rbs cryptosystem rbs lightweight symmetric encryption algorithm targets resource constrained rfid devices unlike existing cryptosystems rbs simultaneously provides confidentiality authentication integrity plaintext inserting hash generated redundant bits among already modified plaintext data flexible length hash algorithm optimized hardware architecture allows rbs support different key sizes allows flexibility security level analysis shows resilience rbs powerful well known attacks differential attacks known plaintext attacks compare performance rbs cryptosystem distinguished ciphers developed rfid systems simulation results show rbs results approximately higher hardware efficiencies requiring less energy per bit compared present grain respectively results present confirmatory evidence rbs superior solution providing security resource constrained systems rfid systems especially authentication priority
personalized anticancer therapy requires continuous consolidation emerging bioinformatics data meaningful accurate information streams use novel mathematical physical approaches namely topology thermodynamics enable merging differing data types improved accuracy selecting therapeutic targets describe method uses chemical thermodynamics two topology measures link rna seq data individual patients academically curated protein protein interaction networks select clinically relevant targets treatment low grade glioma lgg show three histologically distinct tumor types astrocytoma oligoastrocytoma oligodendroglioma may share potential therapeutic targets majority patients would benefit individualized therapies method involves computing gibbs free energy protein protein interaction network applying topological filtration energy landscape produce subnetwork known persistent homology determine likely best target therapeutic intervention using topological measure network known betti number describe algorithm discuss application several patients
density viscosity essential physical properties need well known chemical engineering design well process optimization expand potential application ils important know properties ils mixtures widely used work values density dynamic viscosity aqueous dca molarity range mol measured terms jones dole equation viscosity coefficients large positive value obtained implied ionic liquid water structure making values contribution per mole solute free energy activation viscous flow solution delta equal obtained basis feakins theory relationship delta equal temperature linear standard molar activation entropy delta equal enthalpy delta equal obtained constant molality delta equal temperature independent constant implies activation process solute viscous flow aqueous dca isocoulombic reaction according eyring theory semi empirical method predict viscosity aqueous dca put forward predicted values corresponding experimental ones elsevier rights reserved
desire achieve optimal temperature control building energetic performance description one steps followed identify experimentally dynamic model heat transfer building models used heat equations time domain systems multiple inputs outputs equations represented matrix form manner easily obtain state space representation subsequently transfer function representation furthermore model parameters determined easily used example detailed study normal size house number inside outside parameters monitored
western nations slowly emerge recent global recession demand among citizens authorities practice seen practice ethical leadership although conditions favourable research ethical leadership extant research privileges westernized perspectives ethical leadership largely silent meaning practice ethical leadership context big ethical questions consequence research ethical leadership although well meaning offers little guidance imagine implement sustainable ethical solutions systemic problems research note outline proposal reimagine ethical leadership leadership greater good identify three avenues research leadership greater good compliment existing critical perspectives ethical leadership elsevier ltd rights reserved
unruptured vertebral arteries dissecting aneurysms benign clinical course common symptoms compromise headache neck pain dizziness vomiting optimal endovascular treatment option remains controversial reconstructive techniques many advantages deconstructive ones since advent flow diverters pipeline embolization device ped present case successfully treated ped combination radial access advancement marksman catheter contralateral vertebral artery due special angio architecture patient
similarity search related issues current topic databases last ten years papers dealing similarity databases published according web science rising number articles recent years shows research direction still early stage wide range topics related similarities databases one received considerable attention already namely functional dependencies take similarities account main concern paper review critically examine existing work topic elsevier rights reserved
due harmful effects human life aquatic environments designing easy swift yet efficient methodologies remove pollutants water stream one important tasks scientific community among pollutants dyes significant role water pollution presence even low concentration impacts aquatic life preventing photosynthesis process considered toxic chemicals endangering human health study three newly synthesized task specific ionic liquids tsils incorporating different types aromatic group imidazolium ring namely butyl benzoimidazolium bis trifluoromethylsulfonyl imide bzbim ntf butyl phenyl imidazolium bis trifluoromethylsulfonyl imide bphirn ntf benzyl butyl imidazolum bis trifluoromethylsulfonyl imide bnblm ntf employed remove swiftly heavy loads ppm cationic methylene blue dye aqueous solution without adjustment results showed presence additional aromatic groups significant effect extraction efficiency removal enhancement interactions ils aromatic structure conductor like screening model real solvent cosmo used analyse interaction studied systems finally original microbiological method designed assess toxicity aqueous solution extraction process reveal industrial potential methodology also highlight high hydrophobicity new tsils elsevier ltd rights reserved
paper two efficient cryptosystem schemes form permutation substitution based chaotic systems proposed firstly simple efficient box method introduced order use box designed scheme secure color image encryption technique major advantage proposed strategy dynamic aspect keys used chaotic map generate strong boxes secondly efficient color encryption scheme based chaotic maps boxes form permutation substitution network developed experimental results show effectiveness proposed schemes suggested cryptosystems superior performance great potential prominent prevalence cryptographic applications compared previous schemes
first step improving public health assessment vital signs valuable indicators overall health present day number complex albeit expensive instruments measure various parameters accurately however instruments often tend bulky expensive difficult operate hence difficult use instruments isolated locations rural disaster stricken areas bedside monitoring even military camps objective paper introduce concept user friendly modular system used monitor various physiological parameters efficiently proposed system different sensing circuits attached common microcontroller unit mcu updated associated firmware general computing system laptop connected mcu via usb uart bridge connection established controller starts sending data computer javascript run laptop using open source software called processing initiates customized display various parameters using incoming data data logging store serial data text files proof principle measured two parameters namely body temperature using sensor heart rate using photoplethysmography switchable system used tool measure various parameters like oxygen saturation blood pressure ecg etc computer screen
moisture content one main quality parameters evaluating grading dates study intended design develop electronic portable device based dielectric power spectroscopy nondestructive accurate prediction moisture content dates noncontact parallel plate mode device consists main monitor feeding boards along two elliptical parallel electrodes preliminary tests first carried spectrum analyzer function generator acquire dielectric power spectra dates radio frequency range mhz noncontact parallel plates moisture content predictive models developed adopting different data analysis procedures including multiple linear principle components partial least squares regressions following satisfactory results obtained proposed models many six effective frequencies sefs displayed maximum correlations moisture content selected defined microcontroller developed electronic portable device afterward output voltage device collected new sample set used predict moisture content means artificial neural network ann analysis obtained ann topology enabled excellent prediction moisture content coefficient determination prediction standard deviation ratio sdr values respectively results showed strong potential developed device accurate prediction moisture content dates noncontact parallel plate mode elsevier rights reserved
personal mobility vehicle pmv people limited mobility developed pmv propelled kicking ground foot electric motor assist gliding aims assist short distance transportation urban area moving home train station folding mechanism makes possible carry pmv public transportations help extend area user activities paper overview developed pmv simulation model validation according results preliminary experiments mentioned
purpose review aortic valve disease relatively common encompasses congenital acquired forms bicuspid aortic valve bav common type cardiac malformation predisposes development calcific aortic valve disease cavd since description link notch bav cavd approximately decade ago significant advances genetic molecular understanding diseases recent findings recent work defined congenital cardiac phenotypes linked mutations notch addition novel etiologic genes bav discovered using new genetic technologies humans furthermore several mouse models bav described defining role endothelial notch aortic valve morphogenesis whereas others implicated new genes murine models along cell based studies led molecular insights pathogenesis cavd summary findings provide important insights molecular genetic basis aortic valve malformations including bav specifically highlighting etiologic role endothelial cells addition numerous investigations mechanisms cavd demonstrate importance developmental origins signaling pathways well communication valve endothelial cells underlying interstitial cells valve disease onset progression
paper presents numerical study innovative system converting energy waves consists point pivoted body oscillates presence waves system uses linear electrical generator converts floating movements buoyant body electrical power buoyant body floats describing arc means two hinges suitable power take device pto placed buoy support arms fixed structure function convert mechanical power linear oscillating motion connecting piston electrical power design assumption made pto control system pto reaction force assumed linearly dependent piston oscillation velocity given force speed gain coefficient strictly connected electrical generator characteristics value effect power conversion efficiency scaled model system also tested wave towing tank facility department industrial engineering dii university naples federico variety numerical analyses potential flow simulations unsteady reynolds averaged navier stokes urans simulations performed predict system performances numerical experimental analyses included performances baseline geometry free response wave excitation order characterize response system results used understand parameters affect power production finally numerical optimization procedure carried optimize shape converter final objective increasing generated power eventually imposing constraint amount immersed volume way modified configuration predicted higher power output value submerged volume different shape
european industrial countries severe underweight children due malnutrition uncommon case aeuromonth old infant girl hospitalized severe underweight presented child suffered considerable chronic malnutrition severe reduction body weight reduced growth well general retardation hospital infant quickly recovered adequate food supply predisposition disease could clinically excluded cases degree malnutrition well duration food shortage estimated classification acute chronic malnutrition
spontaneous epileptiform activity previously observed lateral amygdala slices derived patients intractable temporal lobe epilepsy present study aimed characterize intranuclear synaptic connectivity test hypothesis differences spread flow neuronal activity may relate spontaneous epileptiform activity occurrence electrical activity evoked electrical microstimulation acute human brain slices containing signals recorded local field potentials combined fast optical imaging voltage sensitive dye fluorescence sites stimulation recording systematically varied following recordings slices anatomically reconstructed using two dimensional unitary slices reference coronal parasagittal planes local spatial patterns spread activity assessed incorporating coordinates electrical optical recording sites respective unitary slice preferential directional spread evoked electrical signals observed ventral dorsal rostra caudal medial lateral regions differences spread evoked activity observed spontaneously non spontaneously active slices basic properties evoked synaptic responses similar two functional types slices including input output relationship paired pulse depression results indicate directed propagation synaptic signals within human spontaneously active epileptic slices suggest lack differences local systemic information processing found confined epileptiform circuits within amygdala likely involving well known epileptic neurons author published elsevier ltd behalf ibro
two studies examine preferences long term partner conforms traditional non traditional gender roles studies demonstrate link benevolent sexism preference traditional partner however study also demonstrates strong preference among women non traditional partner measured ambivalent sexist ideologies introducing participants either stereotypically traditional stereotypically non traditional character opposite sex study women high benevolence toward men reported preference traditional man compared women low benevolence toward men found link hostility toward men study showed men high benevolent sexism preferred traditional woman men low benevolent sexism case hostile sexism studies provide evidence using ambivalence toward men inventory ambivalent sexism inventory demonstrate relationship benevolent ideology partner choice adds literature partner preference date focused preference dimensions attractiveness resources authors published elsevier ltd open access article license http creativecommons org licenses
blinking behavior important part human nonverbal communication signals psychological state social partner study implemented different blinking behaviors humanoid robot pronounced physical eyes blinking patterns implemented either statistical based human physiological data investigated online study influence different behaviors perception robot human users help godspeed questionnaire results showed condition human like blinking behavior robot perceived intelligent compared blinking statistical blinking argue finding represents starting point design holistic social robotic behavior
background radiofrequency catheter ablation atrial fibrillation become important therapy however recurrence rates remain high proposed determine whether aggressive blood pressure lowering prevents recurrent atrial fibrillation catheter ablation patients high symptom burden methods randomly assigned patients aggressive target standard target seconds determined months beyond catheter ablation blinded end point evaluation results median follow months months mean systolic aggressive treatment group versus years age lower primary outcome event rate aggressive hazard ratio confidence interval higher rate hypotension requiring medication adjustment aggressive group versus conclusions study duration aggressive treatment reduce atrial arrhythmia recurrence catheter ablation resulted hypotension
endoplasmic reticulum aminopeptidase erap involved final processing peptide precursors generate termini mhc class restricted epitopes erap thus influences immunodominance cytotoxic immune responses controlling peptide repertoire available cell surface presentation mhc molecules enable critical role antigen processing erap trims peptides unique molecular ruler mechanism turns hydrolysis activity peptide length sequence dependent manner thus unlike aminopeptidases erap could recognize nand termini peptides order read substrate length exemplify validate molecular ruler mechanism carried crystallographic studies molecular recognition antigenic peptide terminus erap report determined angstrom resolution crystal structure intermolecular complex erapi regulatory domain natural epitope terminus displayed fusion protein reveals structural details peptide termini recognition erap erap uses specificity pockets regulatory domain bind peptide carboxyl end side chain terminal anchoring residue time flexibility length sequence middle peptides accommodated kink minimal interactions erap elsevier ltd rights reserved
substance use disorder sud refers detrimental use psychoactive substances related cluster behavioural cognitive physiological dysfunctions indicating individual continues using substance despite significant substance related problems although one prevalent neuropsychiatric diseases affecting society worldwide mechanism underlying vulnerability certain individuals well understood yet widely accepted addition genetic factors environmental adversities critical stages development organism could also considered risk factors contribute sud suggested prenatal stress could play important role causal mechanisms sud since shown leads individuals poor stress management behavioural problems increase risk sud widely accepted gestational stress exposure rats interferes correct progeny development particular research field points development mesocorticolimbic dopaminergic system sensitive disruption exposure early stressors interestingly induces behavioural abnormalities similar observed individuals present sud since dysfunction mesocorticolimbic pathway reported prenatally stressed sud individuals review summarise current knowledge supporting may serve strong candidate explain vulnerability certain individuals develop sud following repeated drug exposure also propose mechanistic hypothesis explain induced changes mesocorticolimbic system
show linear number vertices removed generalized exchanged hypercube surviving graph consists large connected component smaller component containing altogether rather limited number vertices result applied obtain number fault tolerant properties interesting structure elsevier rights reserved
aim study examine effectiveness progressive muscle relaxation pmr part worksite health promotion program self perceived stress anxiety depression among male automotive assembly line workers quasi experimental trial two assembly plants chosen one receiving pmr therapy pamphlets intention treat analysis conducted test effectiveness relaxation therapy stress depression anxiety levels measured using shortened dass questionnaire data analyzed using chi square independent sample test repeated measures analysis variance test significance effects intervention time group measures stress depression anxiety significant favourable intervention effects stress found pmr group effect size compared pamphlet group effect size significant group time interaction effect stress levels depression anxiety levels minimal baseline groups mild reduction levels improvement stress levels showed potential pmr therapy coping strategy workplace research field necessary examine beneficial effects coping strategies workplace
method developed determine fat content different cold meat products image processing using camera mobile phone salchichon chorizo salami cured ham pictures taken meizu mini mobile phone camera fixed lighting conditions light emitting diode flash mobile phone images treated matlab obtain mean pixels average red green blue camera values colours rgb pixels different data pretreatments taken account correlate colour parameters fat content values determined series commercially available samples soxhlet method rgb values used input variable correlation fat content samples studied using partial least squares pls support vector machine svm best correlation fat content rgb colour descriptors found salchichon salami samples using svm relative errors calibration cross validation prediction respectively use smartphone camera provides easy low cost eco friendly rapid method fat content determination cold meat products elsevier rights reserved
risk assessment infrastructure systems plays increasingly important role plan design maintenance retrofit life cycle cost evaluation taking consideration vulnerability natural technological terrorist hazard paper develops mechanistic model seismic damageability concrete bridges form fragility curve way model calibrated empirical fragility curves constructed basis damage data northridge earthquake often observed destructive earthquakes bridges one vulnerable components highway network system subjected earthquake ground motion reason bridge damageability information succinct fragility curve needed pursue seismic risk assessment highway networks consisting large thousands bridges affected high magnitude earthquake near service area network elsevier ltd rights reserved
discharges widely distributed small point sources pollutants septic tanks contribute microbial nutrient loading streams pose risks human health stream ecology espedally periods ecological sensitivity present first comprehensive data compositional variability septic tank effluents ste potential source water pollution different seasons associated links influence stream waters determine ste parameters nutrient variations biological physicochemical properties effluents sampled quarterly septic tank systems investigated concurrent analyses upstream downstream receiving waters study revealed warmer dryer months spring summer effluents similar composition colder wetter months autumn winter however spring summer effluents differed significantly autumn winter concentrations biological oxygen demand bod arsenic barium cobalt chromium manganese strontium titanium tungsten zinc exception bod greater summer spring concentrations parameters greater winter receiving stream waters also showed significant seasonal variation alkalinity bod dissolved organic carbon sulphate sulphur lithium escherichia coli abundance clear significant influence ste downstream waters relative upstream source total suspended solids total particulate ammonium coliforms coli findings study found seasonal variation ste place effluent discharges factor affecting adjacent stream quality call appropriate measures reduce redirect ste discharges away water courses elsevier rights reserved
article proposes idea development novel frequency tunable electromagnetic energy harvester mainly consists frequency tuning system component electromagnetic energy harvesting component magneto rheological elastomer kind smart material utilized design frequency tuning part using unique rheological characteristic shear modulus altered changing strength external magnetic field external excitation provided system tip magnet oscillates relative coil produce electricity stiffness system equivalent torsional spring composed magneto rheological elastomer blocks altered changing gap distance two tuning magnets results shift primary natural frequency system significant improvement energy harvesting efficiency article presents detailed process design simulation experiment fabrication proposed energy harvester experiments numerical simulations also conducted band limited random excitation support validity present system
work comparison three biogas exploitation paths analyzed energetic economic point view main current available combined heat power cup options traditional internal combustion engine ice solid oxide fuel cell sofc compared furthermore biogas upgrading upc analyzed discussed innovative alternative electrical production currently main issues related agricultural biomass plants addressed reduced subsidies electrical production especially case energy crops feeding wasted thermal energy usually find user surroundings emissions traditional internal combustion engines ices usually exceed limits require use post combustor analysis applied typical biogas plant fed agricultural residues piedmont data current biogas production methane content auxiliaries consumption collected electrical thermal load plant also analyzed order calculate net efficiency system results show positive effects sofc system energy point view respect traditional systems advantages terms electrical production low maintenance costs able generate higher incomes yearly basis even high investment costs still generates current scenario higher payback time pet analyzing future scenario target fuel cell costs almost reached countries market grown usa asia investment reaches interesting economic benefits even compared traditional systems bio methane choice analyzed shows interesting investment cost lower net yearly incomes cumulatively generates slow investment recovery time current scenario authors published elsevier lfd open article license
background emotional dysregulation impaired attachment potential contributors development psychopathology adolescence raises question whether oxytocin paradigmatic attachment hormone may beneficial contexts recent evidence suggests intranasal administration increases affiliative behavior including trust empathy may also facilitate social reciprocity attenuating stress response interpersonal conflict date studies investigated effects intranasal oxytocin neurophysiological emotion regulation strategies healthy adolescents particularly parent adolescent interaction understand mechanisms study examine effects emotion regulation adolescents parent adolescent stressful interactions adolescent visual neurophysiological strategies visualizing attachment related pictures hypothesize influence psychophysiological outcomes conditions stress predict momentarily increase feelings safety attenuate stress hostile behavior conflict situations may also enhance attachment security increasing comfort proximity seeking reducing neurophysiological hyperactivation objective objective study evaluate effects insecure adolescents studying behavior discourse disagreement one parents neurophysiological responses pictures eliciting attachment related emotions visual exploration strategies also investigated methods randomized double blind placebo controlled parallel group design healthy male adolescents classified insecurely attached receive international units versus placebo minutes experimental tasks adolescent invited engage experimental conflict discussion one parents conflict session videotaped coded verbal non verbal interaction behavior using goal corrected partnership adolescence coding system gpacs adolescent asked visualize attachment related pictures screen eye tracking neurophysiological responses including electrodermal activity eda heart rate recorded simultaneously continuously attachment related picture viewing besancon affective picture set adolescents baps ado results enrollment study completed may data analysis commenced july study results submitted publication winter conclusions complex molecule many facets yet fully understood experimental protocol increase scientific clinical knowledge emotion regulation skills insecure adolescents assessing impact parent adolescent interaction visual processing attachment related emotions positive results could lead therapeutic uses treat emotion dysregulation adolescence
background aim explore relationships among perceived stress intestinal inflammation inflammatory bowel disease ibd symptoms time methods participants recruited population based registry persons ibd assessed months key dependent measures manitoba ibd index symptom activity cohen perceived stress scale fecal calprotectin stool intestinal inflammation results complete data available participants months provided follow data active symptoms reported crohn disease ulcerative colitis approximately one third consistently fecal calprotectin measures suggestive active inflammation significant proportion participants indications inflammation active symptoms months correlations month perceived stress disease activity measures values months indicated strong temporal stability hierarchical multiple regression analyses month symptom activity thus strong predictor later symptom activity perceived stress predicted change symptom activity months use prednisone comparably month perceived stress strong predictor later perceived stress month symptom activity predicted change perceived stress months conclusions analysis revealed prospective bidirectional relationships perceived stress ibd symptoms relationship perceived stress change intestinal inflammation assessed fecal calprotectin
objectives assess completeness history taking physical examination notes junior doctors king abdulaziz university hospital per approach learned medical school methods retrospective study reviewed admission notes written junior doctors interns residents academic tertiary care medical centre jeddah saudi arabia two month period notes evaluated completeness using checklist developed reference relevant medical textbooks checklist included items related history taking physical examination based review notes checklist items evaluated complete incomplete present applicable according set criteria data analysed summarised information frequency relative frequency types results history items varied completeness high end asking chief complaint duration associated symptoms aggravating relieving factors conducting systemic review marked complete notes respectively low end asking previous episodes allergies medications family history complete notes respectively physical examination items poorly documented especially breast examination present notes conclusions junior doctors history physicalexamination notes often incomplete follow approach taught medical school reasons must studied via focus group discussions junior doctors
local binary pattern lbp simple efficient texture descriptor image processing recently lbp introduced feature extraction hyperspectral imagery specifically lbp codes extracted band images capture spatial correlation among neighboring pixels statistical histogram features bands could estimate underlying distribution local area concatenated together pixel wise classification however since hyperspectral imagery contains rich spectral spatial information actually data cube lbp dlbp model fully exploit joint spectral spatial structure paper dlbp extended lbp dlbp model forming regular octahedral frame characterize spectral spatial relationship order reflect local continuous property hyperspectral data spectral spatial domains ensuring rotational invariance dlbp model code patterns dlbp model divided eight groups including seven groups dense patterns one group nondense patterns based consistency spectral spatial topology structure specifically patterns seven dense groups correspond microstructures domains spots edges flat areas high percentage dlbp patterns rest patterns aggregated treated nondense patterns proposed method thus called dense lbp dlbp model moreover instead taking zero hard threshold slack variable introduced enable difference central pixel neighboring ones varying small interval could greatly decrease impact spectral variability noise discriminative power features boosted slack threshold based dlbp model named dlbp series experiments conducted three real hyperspectral imageries demonstrate effectiveness proposed two dlbp based methods experimental results show performance proposed dlbp significantly superior dlbp also better dlbp model several state art hyperspectral classification methods
whereas question verbal versus nonverbal primacy gained intensive interest considerably less attention devoted parental response children verbal nonverbal incongruence study comprehensively analyzed parental responses children incongruence mutual interactions parent child interactions structured joint game sequences filmed homes analyzed using mixed multivariate design unexpectedly parents related almost equally verbal nonverbal channels analysis wide range social situational contexts including child sex parent sex ses task difficulty highlighted significant effects delineated contexts activated verbal primacy nonverbal primacy incongruent responses study provides composite theoretical framework relative dominance verbal versus nonverbal communication
one component materials unidirectional fibrous structure new class structural materials mechanically similar biological ones contain channel cracks weak interfaces structure result production technologies effect size shear strength contacts fibers investigated three dimensional analysis elastic inelastic shear extensions interface cracked fiber bundle undamaged fibers tension fiber stacking bundle hexagonal fiber cross sections regular hexagons found energy dissipation interface cracked fiber stress intensity factor crack opening displacement crack fiber length interface non zero shear stresses determined product contact cohesive shear strength contact width optimal cohesive shear strength interfaces channel cracks shall prejudice basic strength characteristics material
study examines associations health stress management hsm practices mental health disability claims data salveo study collected within workplaces nested companies located canada quebec insured large insurance company company interviews conducted human resources managers order obtain data hsm practices companies workplaces sorted low claims high claims groups according median rate population insurer corporate clients logistic regression adjusted design effect multidimensional scaling used analyse data controlling company size economic sector task design demands control gratifications physical activity work family balance associated low mental health disability claims rates analyses revealed three company profiles qualified laissez faire integrated partially integrated approaches hsm three integrated profile associated low mental health disability claims rates results study provide evidence based guidance better control mental health disability claims copyright john wiley sons ltd
voiding dysfunction common disease contributes lower quality life increased prevalence elderly population noninvasive objective methods uroflowmetry ufm voiding diaries vds essential exact diagnosis effective treatment condition patients different causes voiding dysfunction complain lower urinary tract symptoms different treatment options determined based diagnosis made symptoms order improve quality ufm vds provide convenient testing environment several advances made previous investigators study investigate history technological mechanisms ufm vds also aim review ufm viewpoint clinical home uses including recently proposed toilet shaped ufm electronic vds
objective objective study evaluate relevance pla risk prediction among coronary heart disease chd patients methods pla activity measured chd patients included bezafibrate infarction prevention bip study results adjusting patient characteristics traditional risk factors standard deviation pla associated hazard ratio confidence interval mortality cardiovascular events pla significantly improve model discrimination calibration result noteworthy reclassification conclusions results support added value pla predicting cardiovascular events mortality among chd patients beyond traditional risk factor
cold exposure appears activate aspects insect immune system however functional significance relationship cold immunity unclear insect success low temperatures shaped part interactions biotic stressors pathogens thus important understand immunity might activated cold explore components immune system activated whether components differ among different kinds cold exposure exposed drosophila melanogaster acute degrees sustained degrees cold measured potential antimicrobial peptide expression phenoloxidase activity haemocyte counts realised survival fungal infection wound induced melanisation bacterial clearance immunity following recovery acute cold increased circulating haemocyte concentration expression turandot diptericin elicited short term decrease clearance gram positive bacteria sustained cold increased expression turandot effect measures potential realised immunity show measures potential immunity regulated cold whereas realised immunity either unaffected regulated thus hypothesize cold activation potential immunity drosophila may compensatory mechanism maintain stable immune function low temperature exposure elsevier ltd rights reserved
several laboratory model tests carried bearing capacity strip footings reinforced soil foundation reinforced slope compared unreinforced cases deformation failure reinforced earth different foundation conditions monitored analyzed order visualize failure mechanism ground reaches state limit equilibrium new numerical procedure proposed assuming elastic perfectly plastic model smeared shear band approach modified initial stress method enable proposed procedure create explicit collapse mode stress yield condition basis development failure mode deformation foundation bearing capacity strip footings significantly increased inclusion geotextile procedure considers stiffness deformation material may applied complex stability problems
danggui buxue tang dbt ancient chinese herbal decoction containing two herbs astragali radix angelicae sinensis radix asr herbal decoction serves dietary supplement women menopause dbt known modulate immune responses polysaccharide proposed one active components however polysaccharide induced signaling immune activation revealed identifying immune activation triggered dbt could mediated polysaccharide cultured macrophages raw cells application polysaccharide enriched extract dbt significantly increased expressions mrna protein levels interleukin interleukin tumor necrosis factor induction much stronger polysaccharide extract generated singly asr simple mixture induced cytokine release cultured macrophage revealed triggered activation nuclear factor kappa signaling including degradation ikba translocation cytosol nuclei iii activation transcriptional elements results verified possible role dbt polysaccharide modulating immune responses copyright john wiley sons ltd
objective work understand use crack women life stories clinical characteristics gender perspective case study qualitative character participant maria pregnant crack user hospital story permeated violence vulnerabilities family difficulties instruments semi structured interviews clinical cognitive screening revealed preserved cognitive functions generalized anxiety disorder episode hypo maniac past antisocial personality disorder prejudice made access treatment difficult requiring social character interventions specific treatments women use crack
paper dynamics half bridge llc resonant converter investigated based small signal model piecewise regulation studied derived simulation small signal dynamics circuit consideration contain many factors may affect regulation accuracy performance digitally controlled regulators load factor specifically addressed objective paper introduce digital piecewise compensation achieve time optimal response external disturbance step load transient
epilepsy affects people ages genders sex differences well known epilepsy seizure susceptibility incidence epilepsy generally higher men women addition gender specific epilepsies catamenial epilepsy neuroendocrine condition seizures often clustered around perimenstrual periovulatory period adult women epilepsy changes seizure sensitivity also evident puberty pregnancy menopause sex differences seizure susceptibility resistance antiseizure drugs studied experimental models improved understanding neuroendocrine basis sex differences resistance protective drugs essential develop targeted therapies sex specific seizure conditions article provides brief overview current status sex differences seizure susceptibility potential mechanisms underlying gender differences seizure sensitivity published elsevier inc
paper qualitative descriptors images qidl scenes qsnd movements qmd proposed applied ambient intelligent systems improving human computer interaction enhancing reasoning capabilities qualitative descriptors align human perception used produce narratives moreover logic descriptions obtained first order logic prolog syntax enables straightforward reasoning capabilities finally use case tests carried cartesium intelligent building spatial cognition centre university bremen provided show flexibility applicability qualitative descriptors results provided discussed terms usability logic framework used integration descriptors
high torque density robust rotor structure outer rotor switched flux permanent magnet sfpm machine excitation proposed emerging candidates replace conventional electric motor direct drive electric vehicle extraordinary excitation coil provides higher generated flux flux control capability suitable various operating conditions concept motor housing inside wheel mechanical transmission conventionally applied centralized drive eliminated paper proposed machine operating principle predicted back electromagnetic force cogging torque torque production based fea validated experimentally developed prototype results obtained show good agreement fea experiments
study online quality measurement system detecting foreign substances fresh cut lettuce developed using hyperspectral reflectance imaging online detection system single hyperspectral camera range able detect contaminants surfaces fresh cut lettuce algorithms developed system detect contaminants slugs worms optimal wavebands discriminating contaminants sound lettuce well contaminants conveyor belt investigated using one way analysis variance anova method subtraction imaging algorithm classify slugs resulted classification accuracy sensitivity specificity ratio imaging algorithm discriminate worms achieved classification accuracy sensitivity specificity rates respectively overall results suggest online quality measurement system using hyperspectral reflectance imaging potentially used simultaneously discriminate foreign substances fresh cut lettuces iagre published elsevier ltd rights reserved
paper design linear quadratic regulator lqr controller stage solid state transformer sst based quad active bridge qab integrate photovoltaic power generation battery energy storage presented gyrator based average model used deriving state space representation plant dynamic performance designed controller verified extensive simulation switching model validated experimental results
steam generator one major components nuclear power plants thus crucial analyze thermal hydraulic characteristics economical safe operation various analytical codes formulated research secondary side however due complex geometry previous analytical codes certain limitations accurately predicting thermal hydraulic characteristics secondary side paper specialized code named thac thermal hydraulic analysis code steam generator developed summarizing main feature widely used steam generator three dimensional thermal hydraulics calculation codes finite volume method used computation two phase flow natural circulation secondary side complex structure simulated porous media model paper takes guangdong daya bay nuclear power station gnps verification model code simulate dynamically varying void fraction pressure temperature secondary side accuracy reliability code validated used thermal hydraulic analysis steam generator various operating conditions elsevier ltd rights reserved
alloparenting defined care provided individuals parents universal behavior among humans shaped evolutionary history remains important contemporary society dysfunctions alloparenting serious sometimes fatal consequences vulnerable infants children spite importance alloparenting still much learn regarding underlying neurobiological systems governing expression review lack alloparental behavior among traditional laboratory species led blind spot understanding critical facet human social behavior relevant neurobiology based known draw model systems ranging voles meerkats primates describe conserved set neuroendocrine mechanisms supporting expression alloparental care review describe neurobiological behavioral prerequisites ontogeny consequences alloparental care lastly identified several outstanding topics area alloparental care deserve research efforts better advance human health wellbeing wiley periodicals inc develop neurobiol
purpose assumptions gender related media research increased female status would accompanied better representation women also expectations increase number women working news media increase positive representation women aim paper critique representation women leaders managers nigerian press assess extent factors influenced representation women west african country design methodology approach using two methods qualitative content analysis interview chapter critiques representation women leaders managers nigerian guardian life vanguard allure period six months last half determine way women leadership management constructed checking frames stereotypes gender roles trivialisation themes editors two publications interviewed consider philosophies behind coverage patterns assess knowledge awareness implications coverage patterns status women sub saharan african country findings discovered nigerian press focusing enforcing traditional gender roles norms rather challenging women leadership management country apply sufficient agency challenging status quo research limitations implications even though information derived study said represent realities africa surely provides good context within issues media representation women leadership management africa better understood assess cultures continent various countries affect realities lives women originality value bulk feminist research situated north much feminist research done south appears inadequate engagement available literature chapter bridges gap presenting much needed information gender media organisation nigeria highly populous multi ethnic multi cultural sub saharan african country even though information derived study said represent realities africa surely provide good context within issues media gender organisation africa better appreciated
day incredible change social media network like mobile communication computer type data audio video images used communication privacy data important issue cryptography one techniques used stopping unauthorized access increasing integrity data research area encryption decryption scheme used based image pixel shuffling transposition security purpose use cipher algorithm generating key using rgb values pixel instead using pixel values purpose proposed system using size image different operations performed proposed system secure compare existing system
problem secure transmission digital image paid attention network paper designs special image encryption scheme image encryption scheme designed based hyper chaos generalized five order henon mapping five order cellular neural network cnn system firstly chaotic sequence regarded initial conditions cnn system generated five order generalized henon mapping another chaotic sequence produced cnn system last cipher image generated transformation random sequence original image toward end paper makes simulation experiment draws conclusion algorithm image encryption strong attack resistance good safety suitable spread network analyzing statistical characteristics image information entropy correlation histogram well key space sensitivity
choice particular material certain product perform certain function task often jumped either choice looks obvious habits convergent thinking lead engineering designer persist usual material application done early stages product development choice materials involves complex decision making processes balancing intricate functional technological economic criteria reflecting function part product manufacturing process production volumes final cost development teams rely basic methods decide materials using engineering properties benchmarks methods seldom address whole problem material function shape process cost environmental impacts paper starts overview existing methods selecting materials moves onto propose new selection procedure materials selection engine overcomes limitations found former methods uses materials engineering properties accommodate technical fitness also considers life cycle cost items environmental impacts create decision space best materials application mapped classified according importance design team wants give economics environment issues upstream downstream life phases informed decisions made case study presented aiming better understanding procedure proposed elsevier ltd rights reserved
municipal wastewater reuse important way enhance water pollution control water conservation china however many pollutants chemical oxygen demand codcr day biochemical oxygen demand bod contained reclaimed water pollute groundwater environment around rivers lakes supplied reclaimed water therefore environmentally friendly method control infiltration purification quite necessary original sediment one potential option therefore study effects sediment thickness studied water infiltration purification processes riverbed media results indicate infiltration efficiency riverbed media reduced sediment formed gradually reached appreciable level thickness kept ranges removal efficiencies bod codcr ammonium nitrogen nitrate nitrogen total nitrogen total phosphorus respectively sediment soil pillar riverbed media removal efficiencies increased increasing sediment thickness final infiltration rates riverbed infiltration remained steady even thickness beyond purification effect obvious ammonium nitrogen removal efficiency riverbed filtration system appear unlimited increase increase sediment thickness generally existence nitrification denitrification interface located sedimentary layer remained anaerobic bottom thickness ammonium nitrogen involved nitrification nitrate nitrogen concentration percolate tended increase beginning experiments adsorption nitrification took place ammonium nitrogen removed riverbed infiltration system attachment sediments experimental results could used references river regulation
testosterone recent years proven essential normal growth maturation small growing follicles concomitantly low functional ovarian reserve lfor characterized small growing follicle pool associated low testosterone levels ovarian adrenal origin study therefore investigated whether peripheral sex steroid precursors testosterone levels potentially reflect adrenal function retrospective cohort study consecutive infertile women presented academically affiliated fertility center new york city investigated series statistical models whether low peripheral sex steroid precursors testosterone associated peripheral cortisol levels reflecting adrenal function determine potential correlations investigated dehydroepiandrosterone dhea dhea sulfate dheas androstenedione total testosterone free testosterone sex hormone binding globulin shbg anti mullerian hormone amh thyroid stimulating hormone tsh series multivariate logistic regression analyses utilizing either continuous variable cut continuous variable practically models demonstrated significant predictability peripheral sex hormone precursors levels dhea demonstrating strongest consistent predictability individual parameter part dheas dhea ratio conclude infertile women peripheral sex hormone precursors especially dhea reflect levels therefore adrenal function infertile women ages low levels sex hormone precursors therefore considered indications adrenal assessments elsevier ltd rights reserved
gut microbiota includes community bacteria play integral part host health biological processes pronounced repeated findings linked gut microbiome stress anxiety depression currently however remains limited set studies focusing microbiota change substance abuse including alcohol use disorder date studies investigated impact vapour alcohol administration gut microbiome research gut microbiota addiction proceed understanding route drug administration affects gut microbiota must first established animal models alcohol abuse proven valuable elucidating biological processes involved addiction alcohol related diseases first study investigate effect vapour route ethanol administration gut microbiota mice adult male cbl mice exposed weeks chronic intermittent vapourized ethanol cie air control faecal samples collected end exposure followed sequencing bioinformatic analysis robust separation cie control seen microbiome assessed alpha beta diversity notable decrease alpha diversity cie results demonstrate cie exposure markedly alters gut microbiota mice significant increases genus alistipes significant reductions genra clostridium xivb dorea coprococcus seen cie mice control findings support viability cie method studies investigating microbiota gut brain axis align previous research showing similar microbiota alterations inflammatory states alcoholic hepatitis psychological stress elsevier rights reserved
background evidence indicates substance related cognitive biases attentional memory approach bias contribute maintenance development substance misuse impulsivity suggested influence cognitive biases contribute substance misuse possibly biasing incentive salience attribution processes however strength moderators relationship impulsivity substance related cognitive biases yet empirically examined methods meta analysis using random effects models completed assessing studies reported quantitative relationship impulsivity measure substance related cognitive bias two component conceptualisation impulsivity impulsivity measurement type gender age assessed moderators results small significant positive relationship observed impulsivity substance related attentional memory approach biases moderators examined significant influence relationship conclusions results consistent incentive sensitisation theories addiction suggests weak synergistic relationship impulsivity substance related cognitive biases relationship holds across different measures components impulsivity results provide support viability impulsivity cognitive bias interaction models may warrant investigation factors relation predicting addiction treatment outcomes crown copyright published elsevier ireland ltd lights reserved
past three decades insights role cerebellum emotional processing substantially increased indeed methodological refinements cerebellar lesion studies major technological advancements field neuroscience particular responsible exponential growth knowledge topic timely review available data critically evaluate current status role cerebellum emotion related domains main aim article present overview current facts ongoing debates relating clinical neuroimaging neurophysiological findings role cerebellum key aspects emotion experts field cerebellar research discuss range cerebellar contributions emotion nine topics topics include role cerebellum perception recognition forwarding encoding emotional information experience regulation emotional states relation motor cognitive social behaviors addition perspectives including cerebellar involvement emotional learning pain emotional aspects speech neuropsychiatric aspects cerebellum mood disorders briefly discussed results consensus paper illustrate theory empirical research converged produce composite picture brain topography physiology function establishes role cerebellum many aspects emotional processing
rna silencing conserved mechanism utilizes small rnas srnas direct regulation gene expression transcriptional post transcriptional level plants utilizing rna silencing machinery defend pathogen infection first identified plant virus interaction later observed distinct plant pathogen interactions rna silencing responsible suppressing rna accumulation movement virus viroid also facilitates plant immune responses bacterial oomycete fungal infection interestingly even plant srna perform different roles encounters different pathogens side pathogens counteract generating srnas directly regulate pathogen gene expression increase virulence target host genes facilitate pathogen infection summarize current knowledge characterization biogenesis host pathogen derived srnas well different rna silencing machineries plants utilize defend different pathogens functions srnas defense counter defense mechanisms regulation different plant pathogen interactions also discussed
ventilation intentional air supply closed space outside essential sake comfortable environment health human beings recent wide spread renewable energy much attention paid natural ventilation natural ventilator classified fixed type venturi type wind turbine type study ventilation rates fixed type ventilator experimentally investigated changing wind velocity additionally condition backflow also examined according experimental results ventilated air flow strongly depended outside wind velocity also intake opening area reverse flow test confirmed reverse flow ventilator occurred wind velocity certain threshold value furthermore reverse flow phenomenon severe obstacle located downstream ventilator
representation curves surfaces basic topic computer graphic computer aided design cad paper focus theoretical practical issues using radial basis functions rbf reconstructing implicit curves surfaces point clouds study conditioning problem give insight problem parameters results taken order achieve meaningful solutions avoid artifacts moreover strategy decreasing conditioning problem suggested general framework preconditioning solving problem even large datasets also provided imacs published elsevier rights reserved
coupling unsteady heat release acoustic perturbations lead self sustained thermoacoustic oscillations also known combustion instability combustion instability occurs pressure oscillations may become intense cause engine structural damage costly mission failure thus need develop real time monitoring control approach enables engine systems operated stably work online monitoring optimization algorithm developed stabilize unstable thermoacoustic systems characterized nonlinear limit cycle oscillations based least mean square method lms performance optimization algorithm evaluated first van der pol oscillator produce nonlinear limit cycle oscillations similar pressure oscillation frequently observed gas turbine engines shown implementing control strategy leads oscillations quickly decayed validate control strategy experimental study conducted rijke tube found approximately sound pressure reduction achieved actuating loudspeaker addition control approach demonstrated able track prevent onset new limit cycle thermoacoustic oscillations resulting changes fuel flow rate present work opens new applicable approach stabilize engine system terms minimizing thermoacoustic oscillations elsevier ltd rights reserved
child maltreatment often occurs within family often expression inability parents cope child needs parental distress results inadequate conscious unconscious never accidental overreactions resulting severe physical psychological sequelae furthermore individual healthcare costs society extensive therefore early identification children adolescents risk paramount importance due position trust relationship families pediatricians play important role recommended preventive medical check ups regular contacts provide opportunity early recognition child maltreatment implementation measures prevent harm knowledge risk factors potential triggers availability community programs resources help affected families indispensable prerequisites
self conscious emotions guilt shame self disgust well self related motives self enhancement self verification influence people perceive evaluate memorize respond self related information influence peoples concepts may also affect behavior social environments current review describe alterations self related processing borderline personality disorder bpd chose bpd example mental disorder impairments self functioning identity constitute major feature since terminology used clinical research self referential processing diverse often confusing start reviewing main concepts area research using conceptual framework provided social psychology studies self referential processing bpd focused descriptions self esteem revealed negative self concept particularly expressed explicitly reported low self esteem moreover self esteem unstable bpd likely reactive self relevant cues bpd patients prone negative emotions respect self disgust shame first data point altered self related motives conclusion although explicit self esteem widely studied global trait like feature bpd strong lack studies take complexity construct self esteem account studies alterations self related processes required deepen understanding impairments self concept bpd enable improvement psychosocial therapeutic approaches
object motocross racing popular sport however impact growing developing pediatric spine unknown using retrospective cohort model authors compared degree advanced degenerative findings young motocross racers findings age matched controls methods patients treated motocross related injury authors institution years age time injury undergone plain radiographic examination spinal region eligible inclusion imaging reviewed blinded fashion physicians degenerative findings including endplate abnormalities loss vertebral body height wedging malalignment acute pathological segments excluded spine radiographs age matched controls similarly reviewed findings compared results motocross cohort consisted riders mean age years male control cohort consisted adolescents mean age years male cervical spine motocross cohort abnormalities segments average abnormalities patient compared abnormalities segments controls average patient student test thoracic spine motocross riders abnormalities segments average abnormalities patient compared abnormalities segments controls average patient lumbar spine motocross cohort abnormalities segments average abnormalities patient compared abnormalities segments controls average patient conclusions increased degenerative changes cervical thoracic spine identified adolescent motocross racers compared age matched controls long term consequences changes unknown however athletes parents counseled accordingly participation motocross activities
quantum key distribution protocol traditional bob proposed recently boyer using single particle state paper semi quantum key distribution protocol described einstein podolsky rosen epr pairs particles utilized generate secret key remote places extends quantum key distribution protocol traditional bob single qubit channel replaced entangled epr pair channel quantum alice able quantum operations preparing quantum states performing quantum measurement traditional bob able prepare measure particle computational basis reflect particles furthermore entanglement states used protocol analysis shows protocol secure avoid beam splitter attack automatically proposed protocol efficient boyers scheme
background diarrhea predominant irritable bowel syndrome ibs functional disorder gastrointestinal tract major ibs symptoms include diarrhea abdominal pain discomfort high density opioid receptors ors tract participation maintenance homeostasis make ors ligands attractive option developing new anti ibs treatments aim study characterize effect methyl orvinol motility secretion mouse models mimicking symptoms ibs methods vitro effects methyl orvinol electrical field stimulated smooth muscle contractility epithelial ion transport characterized mouse colon vivo following tests used determine methyl orvinol effect mouse motility colonic bead expulsion whole transit fecal pellet output antinociceptive action methyl orvinol assessed mouse model visceral pain induced mustard oil results methyl orvinol inhibited colonic smooth muscle contractions concentration dependent manner effect reversed naloxone non selective opioid antagonist beta funaltrexamine selective mop antagonist experiments selective kop receptor agonist revealed methyl orvinol kop receptor antagonist tract methyl orvinol enhanced epithelial ion transport vivo methyl orvinol inhibited colonic bead expulsion prolonged transit methyl orvinol improved hypermotility reduced abdominal pain mouse models mimicking ibs symptoms conclusion methyl orvinol could become promising drug candidate chronic therapy functional diseases ibs institute pharmacology polish academy sciences published elsevier rights reserved
objectives investigate impact obesity response first tnf alpha inhibitor tnfi treatment course patients psa followed routine care methods performed observational cohort study based danish icelandic biologics registries kaplan meier plots cox logistic regression analyses performed study impact obesity bmi tnfi adherence response months according improvement acr criteria eular criteria subanalyses studied impact obesity according gender tnfi type nationality results among psa patients icelandic danish identified registries available bmi obese median follow time years interquartile range iqr obese patients higher baseline disease activity example joint das mean crp median iqr visual analogue scale pain iqr compared non obese patients tnfi adherence shorter obese patients especially among men median tnfi duration years obese non obese patients eular good moderate egom response achieved obese non obese patients months multivariable analyses obesity increased risk tnfi withdrawal hazard ratio reduced odds egom response odds ratio impact obesity significant across genders tnfi types nationality conclusion obesity associated higher disease activity seemed diminish response adherence tnfis psa
study investigates influence viewing situations solovs group viewing interpersonal communication group viewing situation television entertainment field study combining survey video observation entertainment participants watching television alone group entertainment different groups compared assess interpersonal communication watching television group verbal nonverbal communication behavior recorded results suggest presence others influence viewers core enjoyment amount nonverbal communication behavior affect viewers core enjoyment particular topics conversation influenced specific enjoyment qualities conversations indicating involvement television show intensifying viewers empathy conversations indicating emotional experiences watching television decreasing viewers suspense results discussed regarding nonverbal verbal mechanisms underlie entertainment different social conditions
assembly disassembly sequence planning hard combinatory problem assembly parts numbers become important reduce difficulty especially case complex products subassembly identification concept constitute original way aims decompose complex assembly product subassembly entities containing small number parts consequently generation assembly disassembly sequence planning parts becomes subassemblies case determined relatively easily despite prettiness subassembly method identification subassembly computer aided design cad model remains relevant research subject improved paper subassembly identification approach presented proposed approach begins exploration cad assembly data carry adjacency matrix identify subassemblies extracted matrix transformed three steps first step consists idealizing matrix removing connection parts identified feature manager permits reducing size afterward based reduced matrix direction matrix constructed identify base part subassembly third step consists enriching direction matrix mounting conditions construct set subassemblies example cad assembly mechanism presented sections paper order explain discuss steps proposed approach
ankylosing spondylitis complex chronic inflammatory disease high heritage previous study shown involved inflammatory reaction little known single nucleotide polymorphisms snps associated conducted case control study among cases healthy controls china genetic model analysis found genotype associated decreased risk dominant model log additive model genotype significantly associated decreased risk based dominant model log additive model additionally minor allele may also reduce risk dominant log additive model results suggested polymorphisms associated susceptibility chinese han population studies needed characterize functional sequences cause
introduction leptomeningeal metastases lymphoma remain difficult complication oncologist due high incidence morbidity mortality early diagnostic initiation treatment essential prevent neurological deterioration areas covered review several proteomic approaches described order help provide basis identification biomarkers useful early diagnosis also discovery novel targets therapeutic agents fact identification biomarkers high potential detect leptomeningeal lymphoma well predict progression treatment response expert commentary case central nervous system cns lymphoma studies generated first insights utility proteomic analysis biomarker identification demonstrated identifying specific proteins cerebrospinal fluid csf much greater sensitivity detecting comparison standard cytological protocols
advent next generation sequencing ngs vastly increased ability discover novel viruses systematically define spectrum viruses present given specimen studies led discovery novel viral pathogens well broader associations virome diverse diseases including inflammatory bowel disease severe acute malnutrition hiv aids critical success efforts robust bioinformatic pipelines rapid classification microbial sequences existing computational tools typically focused either eukaryotic virus discovery virome composition analysis present virusseeker blast based ngs data analysis pipeline designed purposes virusseeker successfully applied several previously published virome studies demonstrate functionality virusseeker novel virus discovery virome composition analysis
industry model predictive control mpc solutions high computational requirements usually implemented based devices main goal study implement mpc algorithm programmable logic controller plc paper describes initialization part solution represents internal model pre processing algorithm implemented function blocks created plc programming standard iec pre processing algorithm changes model representation form multivariable system mimo continuous transfer function matrix generalized discrete state space model end paper shown created comfortable interface used inserting transfer functions process model parameterization future mpc tuning interface communicating pre processing algorithm running plc allows specify mimo internal model continuous transfer function matrix discrete state space internal model used control created automatically operator use matlab expansive mathematical software creation discrete state space representation widespread mathematical description industry known like continuous transfer function used constants transfer functions usually obtained operator current visualizations plant
purpose neurovascular interventional procedures using biplane fluoroscopic imaging systems lead increased risk radiation induced skin injuries authors developed biplane dose tracking system biplane dts calculate cumulative skin dose distribution frontal lateral ray tubes display real time color coded map graphic patient immediate feedback physician agreement calculated values dose measured phantoms evaluated methods biplane dts consists multiple components including graphic models imaging system patient interactive graphical user interface data acquisition module collect geometry exposure parameters computer graphics processing unit functions determining parts patient graphic skin surface within beam calculating dose dose calculated individual points patient graphic using premeasured calibration files entrance skin dose per mas including backscatter corrections applied field area distance focal spot patient table pad attenuation appropriate agreement calculated patient skin dose spatial distribution measured values evaluated simulated procedure conditions using pmma block phantom head phantom respectively dose values calculated biplane dts compared measurements made phantom surface radiochromic film calibrated ionization chamber also used calibrate dts agreement measurements specifically evaluated variation kvp gantry angle field size results dose tracking system developed able acquire data two ray gantries biplane imaging system calculate skin dose exposure pulse vertices patient graphic determined beam calculations done real time typical graphic update time average vertex separation appropriate corrections applied biplane dts able determine entrance dose within spatial distribution dose within compared measurements ionization chamber film head phantom cumulative dose overlapping fields gantries showed similar agreement conclusions biplane dts provide good estimate peak skin dose cumulative skin dose distribution biplane neurointerventional procedures real time display information help physician manage patient dose reduce risk radiation induced skin injuries american association physicists medicine
urban vegetation influenced prior land use due dynamic nature urban landscape however limited information available strongly land use legacy impacts diversity urban vegetation especially areas rapid urbanization study quantified land use legacy effect taxonomic functional diversity woody plants haikou china collected data land use percentages woody vegetation cover abundance woody plants randomly distributed sample plots influence land use legacy examined analyzing land use history sample plots taxonomic functional alpha beta diversity woody plants relative importance land use percentage woody vegetation cover diversity woody plants analyzed using boosted regression tree model result showed land use legacy effect caused significant divergence taxonomic functional diversity woody plants effect obvious sites lands currently used residential areas remnant trees shrubs possibly shrubs growing seed banks roots contributed legacy effect also found taxonomic functional diversities trees site influenced frequent land use place changed type land use place ended based findings recommend conservation programs rapidly urbanizing regions give attention vegetation residential areas particularly species low utilitarian value elsevier rights reserved
research increasingly suggests moderate vigorous physical activity mvpa essential children health however little known extent different urban environments influence extent children engage mvpa end study explores relationship children mvpa urban land use land cover lulc several temporal subdivisions children weekly routines school school weekends particular location corresponding level physical activity grade students recorded using paired global positioning system gps receivers accelerometers days student gps locations temporally related accelerometry records geographically related categories lulc mixed linear models fitted evaluate extent duration spent lulc category explain individuals time mvpa school school weekends geographic cluster analysis also applied assess whether significant spatial relationships observations mvpa may exist duration exposure vegetated parks open spaces built residential built institutional lulc found significantly increase children time spent mvpa observations mvpa found exhibit significant geographic clustering predominately associated built residential areas particularly near schools indicating importance neighborhoods areas close proximity children households level physical activity authors published elsevier open access article license
brushless bldc motors widely used various low power drive applications owing several advantages conventional motors study describes fuzzy logic based improved loss minimisation technique bldc motor drive system proposed algorithm uses selective harmonic elimination based pulse width modulation optimise converter switching losses along machine core copper losses based speed load dependent fuzzy rule matrix optimum switching angles eliminating lower order harmonics calculated offline stored microcontroller memory online application suitability proposed control well demonstrated simulation experimental results practical bldc machine
deep neural networks image video classification obtained much success various computer vision applications existing deep learning algorithms widely used rgb images video data meanwhile development low cost rgb sensors microsoft kinect xtion pro live high quality rgb data easily acquired used enhance computer vision algorithms would interesting investigate deep learning employed extracting fusing features rgb data paper briefly reviewing basic concepts rgb information four prevalent deep learning models deep belief networks dbns stacked denoising auto encoders sdae convolutional neural networks cnns long short term memory lstm neural networks conduct extensive experiments five popular rgb datasets including three image datasets two video datasets present detailed analysis comparison learned feature representations four deep learning models addition suggestions adjust hyper parameters learning deep neural networks made paper according extensive experimental results believe evaluation provide insights deeper understanding different deep learning algorithms rgb feature extraction fusion elsevier inc rights reserved
present easyhouse system developed allow people disabilities family members control home environment turn light turn using smartphone user interface designed adjustable needs user development easyhouse followed iterative user centered design approach paper based low fidelity prototype built based user requirements first author experience researcher cerebral palsy several design evaluation iterations functional prototype evaluated real context real users preliminary results indicate proposed system suitable people without motor disabilities provides adequate method controlling home appliances family member motor disabilities
evaluated underlying causes differences latent heat fluxes measured two enclosed path eddy covariance systems two measurement levels independent estimates open oak tree grass savannah almost one year estimates well stablished underlying grass replicated weighable tension controlled lysimiters lelye provided robust baseline compare measured ground similarly ecosystem level scaled using independent measurements leupscaled sap flow lysimeter benchmarked derived estimates measured tower ground adjusted close energy balance using bowen ratio method lebowen beta derived energy budget residual leresidual sensitivity correction method applied corrections low pass filtering effects water vapor fluctuations called angle attack correction impact energy balance closure ebc also evaluated comparison heights showed grass dominated annual evaporative loss depending upon spectral correction method applied results revealed substantial underestimation compared lelys mostly occurred growing season however differences remarkably lower likening versus leupscaled suggesting dampening water vapor fluctuations due low pass filtering effects pronounced near surface interestingly diagnostic evaluation errors random forest model showed differences followed quite structured patterns associated certain atmospheric conditions turbulent mixing deficiencies stable atmospheric stratification addition model showed differences increased increasing relative humidity soil moisture results revealed degree ebc highly sensitive flux correction method applied particular correcting flow distortion effects typically turbulent fluxes fell measured available energy slope slope switched abruptly angle attack correction applied slope consistent ebc independent estimates matched well lebowen ebc gap decreased leupscaied used slope use independent estimates together machine learning methods proposed powerful means diagnose complexity behind errors give insights energy imbalance problem addition inherent randomness data accounting uncertainties associated appropriateness correction method applied highly recommended elsevier rights reserved
smoking cessation become real social challenge healthcare domain persuasive technologies combined ambient intelligence figure possible approaches addiction choosing effective persuasive design relies different models principles coming several scientific contexts evaluate triggers defined fogg model different design strategies implementing three experiments first using smoking tools second android application third one using application coupled arduino based ambient device cregrette system proof concept suggests statistics combined ambient device effective notifications mirroring self monitoring approaches article furthermore proposes design strategies research perspectives support research field persuasion ambient device design
study aim aim study twofold first compare incidence injuries male female athletes junior youth divisions competition well identify body parts commonly injured types injury frequently incurred second assess overall incidence injuries relation frequency duration training well supplemental training material methods subjects filipino judokas competing major divisions national competition manila injury rates expressed per athlete exposures confidence intervals around rates computed results difference injury rate boys athlete exposures girls although boys higher risk girls difference significant junior women higher risk girls neither training frequencies sessions per week training durations hours significant predictors injury supplemental training found related occurrence injuries conclusion judo relatively safe physical activity young adults children training variables frequency duration supplemental training influence occurence injury
among potential environmental harmful factors fungi deserve special consideration intrinsic ability actively germinate infect host tissues might determine prominent trigger host defense mechanisms appearance fungi evolutionary history organisms evolve strategies recognize cope existing controversies around dampness mold hypersensitivity syndrome dmhs due great variability clinical symptoms also possible eliciting factors associated mold dampness hypothesis presented evolutionary analysis different response patterns seen dmhs able explain existing variability disease patterns classical interpretation immune responses symptoms addressed within field pathophysiology presented evolutionary analysis seeks ultimate causes vast array symptoms dmhs symptoms interpreted induced direct toxic actions spores mycotoxins fungal metabolites side host initiated response aims counterbalance fight potentially deleterious effects fungal infection individual susceptibility immune reactions confer exaggerated response magnified symptoms explained terms immunopathology ige mediated allergy fits well scenario individuals atopic predisposition suffer exaggerated response mold exposure studies addressing responses evolved could advantageous scarce human history plenty plagues diseases connected mold exposure could explain vulnerability mold allergy likewise multiorgan symptoms dmhs analyzed possible adaptive role defense active infection also evolved mechanisms avoidance potentially harmful environments evolutionary past present setting
last three decades ample research demonstrate instituting multisystemic therapy serious juvenile offenders keeping community intensive intervention significantly reduce recidivism recidivism less severe released incarcerated juveniles multisystemic therapy provides available parental guidance family therapy individual therapy group therapy educational support quite importantly change peer group new york city new mandate juvenile justice initiative implement interventions keep juvenile offenders community rather sending incarcerated however paper aims examine teaching prosocial values early childhood reduce incidence first time juvenile delinquency programs perry school project discussed demonstrate although somewhat expensive innovative programs nonetheless quite cost effective cost society adjudication incarceration victim damages significantly greater along teaching prosocial values renewed interest early identification youth risk developing antisocial personality disorder update given status promising approaches early intervention prevent serious juvenile delinquency hence adult criminality
introduction primary myelofibrosis pmf least common aggressive classic philadelphia chromosome negative myeloproliferative neoplasms survival much shorter pmf polycythemia vera essential thrombocythemia post myelofibrosis clinically indistinguishable pmf approached similarly areas covered current pharmacologic therapy revolves around janus kinase jak inhibitor ruxolitinib dramatically improves constitutional symptoms splenomegaly majority patients improves overall survival however allogeneic stem cell transplantation remains potential cure jak inhibitors continue developed momelotinib pacritinib phase iii clinical trials anemia common initially worsened ruxolitinib momelotinib pacritinib may prove advantageous regard current strategies managing anemia include danazol immunomodulatory drugs erythroid stimulating agents either alone combination ruxolitinib expert opinion number agents representing diverse drug classes various stages development include newer jak inhibitors signaling inhibitors epigenetic modifiers anti fibrotic agents telomerase inhibitors activin receptor ligand traps anemia hopefully novel therapies extend clinical benefits ruxolitinib
osteoarthritis one frequent pathologies affecting temporomandibular joint tmj evidence use intra articular hyaluronic acid treatment disorder achieves positive effects reduction inflammatory mediators systematic review available evidence regarding regulation inflammatory mediators applying osteoarthritis tmj humans performed web science embase sciencedirect medline scopus ebscohost lilacs databases scielo library search engine trip database searched systematically two thousand eight hundred sixty three related articles found two met selection criteria clinical trials evidence level treatment studies two articles represented population patients articles reported application positive effect regulation inflammatory mediators mediators studied plasminogen activator system levels nitric oxide limited evidence available suggests application regulates various inflammatory mediators osteoarthritic processes tmj nevertheless evidence regard required study specific pathologies tmj complementing assessment clinical parameters molecular studies generating good quality clinical studies larger sample sizes
robotic manipulators multi input multi output dynamically coupled highly time varying complex highly nonlinear systems wherein external disturbances parameter variations random noise adversely affects performance robotic system therefore order deal complexities however intriguing task control researchers systems require efficient robust controller paper novel application genetic algorithms optimization approach optimize scaling factors interval type fuzzy proportional derivative plus integral itfpd controllers proposed dof redundant robot manipulator trajectory tracking task five controllers parameters optimized simultaneously procedure selecting appropriate initial search space also demonstrated order make fair comparison different controllers tuning controllers parameters done optimization technique uses time domain optimal tuning minimizing fitness function sum integral multiplication time square error itse joint ascertain effectiveness itfpid controller compared type fuzzy pid tifpid conventional pid controllers furthermore robustness testing developed itfpid controller external disturbances parameter variations random noise rejection also investigated finally experimental study leads claim proposed controller assure best trajectory tracking joint cartesian space also improves robustness systems external disturbances parameter variations random noise elsevier ltd rights reserved
paper investigate optimal control burgers equation optimal distributed neumann boundary control problems dubovitskii milyutin functional analytical approach adopted investigation pontryagin maximum principles systems necessary optimality conditions respectively presented two kinds optimal control problems fixed free final horizon cases four extremum problems moreover free final horizon case assumptions admissible control set convexity non empty interior removed set including interesting case contains finite many points finally remark utilize obtained results also made illustration
evolution cognitive behavioral therapy cbt treatment bulimic disorders described review impacts successive attempts enhance cbt addition exposure response prevention development enhanced cbt broadening treatment bulimia nervosa binge eating disorder considered addition developing advanced forms cbt shortening treatment guided self help first step broadening access treatment use technology computer based therapy recently internet promises broadening access self help therapist guided treatment controlled studies area reviewed balance risks benefits accompany use technology lessened therapist input considered looking future sophisticated forms treatment delivered mobile applications apps may lead personalized efficacious treatments bulimic disorders thus enhancing delivery treatments eating disorders elsevier ltd rights reserved
background assess efficacy safety intradetrusor onabotulinumtoxina onabota injection treatment patients neurogenic lower urinary tract dysfunction nlutd especially patients parkinson disease methods patients refractory oral antimuscarinic participated label use study evaluated prior onabota injection detrusor muscle including trigone changes due treatment evaluated using bladder diaries urodynamics questionnaires statistical analysis comprised wilcoxon rank sum test values presented mean standard deviation results ten patients female male mean age years lutd enrolled patients tolerated treatment bladder diary variables decreased significantly onabota injection compared variables prior injection desire void maximum bladder capacity increased significantly urodynamics maximum detrusor pressure voiding phase normalised detrusor overactivity less often detectable patients voided spontaneously mean post void residual pvr volume postoperatively urinary retention side effects observed treatment mean follow time months range patients requested repeated injection mean period months first second injection conclusions data confirm efficacy safety onabota injection patients neurogenic lutd due risk urinary retention high post urinary residual volumes seems minor onabota injection research needed larger sample size confirm significance findings
strength materials always reduced presence notches cracks phenomenon known notch sensitivity critical structural design good structural materials ductile metals elastomers tend notch insensitive considered optimum behavior report inverse notch insensitivity failure stress notched specimen higher unnotched counterpart achieved polypropylene nonwoven fabrics behavior possible peculiar microstructure nonwoven fabrics fracture interfiber bonds provides source non linear deformation leads change network topology former facilitates crack tip blunting spreading damage ligament orientation fibers perpendicular notch plane strengthens material improves maximum load bearing capability elsevier ltd rights reserved
ionic polymer metal composite abbr ipmc type smart material consisting two layers noble metal ion conducting layer smart terials generally capable actuating sensing mechanical deformation ipmc beam produces electric potential difference order proportional tip displacement electrodes paper sensing capabilities ipmc samples investigated composites manufactured form thin plate cut rectangular samples tests performed separate samples two electrically connected samples response various frequencies tested sample two mechanically electrically coupled samples creating simple sensor array
background component resolved allergen diagnosis allows precise evaluation sensitization profiles patients sensitized felines canines accurate interpretation results allows better insight evolution given patients sensitizations allows precise evaluation prognoses methods patients women men aged average positive feline canine allergy diagnosis included research group patients negative allergy diagnosis included control group total ige levels patients allergies well allergen specific ige feline canine allergens measured specific ige levels canine feline fel fel fel allergen components also measured use immunocap method results monosensitization one canine feline component found patients predicted main feline allergen fel sensitized many patients sensitized felines among patients sensitized least one feline component patients sensitizing feline component fel patients group simultaneously sensitized dogs isolated sensitization feline fel notwithstanding displayed concurrent sensitizations one canine allergen components fel sensitized research group patients sensitized canine components heightened levels specific ige monosensitization group occurred patients sensitization observed among patients conclusions concurrent sensitizations allergic components cross reactive also originating different protein families significant problem patients sensitized animals
friction properties geotextile interfaces play important role stability geotextile encapsulated sand systems coastal protection stabilising action frictional force important oppose sliding along contact surface prevent deformations may lead structural failures paper presents set experiments based large scale direct shear tests performed cyclic loading cyclic displacement conditions examining friction interfaces geotextile specimens sand filled geosystem elements sand layer sand filled geosystem element results presented indicate friction parameters shear strength friction angle derived geotextile specimens obtained sand filled elements suggests using former stability analysis conservative tests carried sand layer surface showed modification shear plane slope likely occur sand filled geosystem element buries sand layer deformation result toe instability ultimately leading progressive damage even collapse entire structure elsevier ltd rights reserved
background asthma incomplete reversibility airway obstruction iraq may often associated smoking induced changes nevertheless high proportion patients showing irao never smoked patients irao often share features patients chronic obstructive pulmonary disease copd although iraq still poorly defined condition associated higher morbidity mortality asthma complete reversibility airway obstruction crao even copd alone high prevalence comorbidities could contribute reported poorer clinical outcome iraq comparison crao copd alone aim determine prevalence past current comorbidities irao patients compared patients crao copd methods retrospective cross sectional study demographic data clinical characteristics predetermined comorbidities documented self report chart review recorded smoking associated iraq iraq non smoking iraq irao crao copd patients results total patients included final analysis mean age years crao group comorbidities three groups difference significant irao group comorbidities prevalence comorbidities iraq sub groups intermediate crao copd significant differences iraq irao hypertension nasal polyps pneumonia typical asthma associated comorbidities tended prevalent iraq patients copd associated comorbidities iraq patients conclusion study prevalence comorbidities superior patients iraq compared crao copd alone prevalence comorbidities two main types iraq patients reflects exposure cigarette smoke asthma related mechanisms published elsevier ltd
goal brief report demonstrate utility quantifying parental discipline practices relative frequencies measuring changes parenting behavior relations child behavior following intervention explored comparisons across methodological approaches assessing parenting behavior via absolute relative frequencies measuring improvements parent reported disciplinary practices increases positive parenting practices response child behavior decreases inconsistent discipline use corporal punishment child behavior problems current study conducted part larger clinical trial evaluate efficacy collaborative care intervention behavior problems adhd anxiety pediatric primary care practices doctor office collaborative care docc participants parent child dyads child age male children eight pediatric practices cluster randomized docc enhanced usual care euc parents reported discipline behaviors child behavior problems treatment related decreases negative parenting found using absolute relative frequencies parenting behaviors results different positive parenting behaviors showed decreases measured absolute frequencies increases measured relative frequencies addition positive parenting negatively correlated child behavior problems using relative frequencies absolute frequencies relative frequencies positive parenting mediated relations treatment condition outcomes findings indicate methods used measure treatment related change warrant careful consideration
study order determine efficiency estimating annual water pollution loads remote sensed land cover classification ground observed hydrological data empirical model investigated remote sensing data imagery national oceanic atmospheric administration noaa advanced high resolution radiometer applied year water quality dataset different rivers japan six water quality indicatorstotal nitrogen total phosphorus biochemical oxygen demand bod chemical oxygen demand cod dissolved oxygen examined using observed river water quality data generated land cover map bod cod loads estimated river basins using empirical model calibration validation results showed proposed simulation technique useful predicting water pollution loads river basins found vegetation land cover larger impact export rivers urban areas small impact export rivers relatively large impact bod export results indicate application land cover data generated remote sensed imagery could give useful interpretation river water quality
background thyroid dysfunction hypertension htn sporadically reported sunitinib sun sorafenib sor determination side effect incidence enhance monitoring management recommendations methods observational cohort study performed using deidentified pharmacy claims data year period evaluate patients prescribed sun sor capecitabine cap comparison group primary outcome time first prescription thyroid replacement htn treatment hazard ratios hrs confidence intervals cis estimated cox proportional hazards models results total patients eligible evaluation thyroid replacement therapy initiated receiving sun receiving sor receiving cap median time initiation months range months total patients eligible evaluation htn therapy initiated sun recipients sor recipients cap recipients median time initiation month range months sor months range months sun conclusion sun sor significantly increased risk clinically relevant hypothyroidism risk least times greater sun sor patients receiving sun sor similar elevated risk clinically relevant htn data provide robust measures incidence time onset clinically actionable adverse events
past half century discourse emphasizing environmental constraints limits informed provided many valuable ways responding complex environmental problems strongly shaped green building practices associated environmental assessment methods paper delineates concept regenerative sustainability net positive approach sustainability rooted notion procedural sustainability particular stream constructivist social theory paper contrasts concept regenerative development design although many commonalities based different philosophical underpinnings since origins regenerative sustainability regenerative design lie primarily social ecological domains respectively understanding relationship importance formulating approaches successful evolution human natural systems paper describes relationship regenerative sustainability regenerative design including discussion key points convergence divergence concludes exploration practical implications regenerative sustainability concept
paper presents new simulator platform basic electric circuits shows operation circuits space simulator first literature makes use advantages graphing generated flash provide interactive work environment user simulator makes two types simulations exclusive results presented nodal voltages branch currents shows magnitudes phases nodal voltages circuit novelty simulator spatial geometry operation electrical circuits advantage presenting results environment able observe analyze quickly nodal voltages branch currents distributed circuit whole well magnitudes phases nodal voltages also expected new form study basic electric circuits open new way facilitate understanding concepts engineering students simulator runs internet browser electrical analysis values pspice
cloud used outsource data storage data computation data computation outsourcing enables move computationally expensive operations outside mobile device many pairing based cryptographic schemes designed enable documents encryption fulfilling defined security requirements practice client applications implemented mobile devices computational capabilities significantly lower standard computers thus advanced cryptographic calculations like bilinear pairing calculation might take much time good user experience paper analyse possibilities securely outsource bilinear pairings computation mobile device possibly dishonest servers several test scenarios implemented also modified one pairing based schemes allows encrypt decrypt documents created secure outsourced version next tested execution times encryption decryption algorithms original scheme outsourced version tests conducted using different outsourcing models execution times showing time spent mobile device server presented discussed tests shown certain conditions outsourcing bilinear pairing calculation speed overall computation time also simplifies implementation different mobile operating systems
electrocardiogram ecg detection patients heart health important technical means load heart added motion heart diseases likely induced signal detection ecg moving state necessary ecg signal weak bioelectrical signal susceptible environmental interference especially state motion ecg includes main interference signals motion jitter interference frequency interference baseline drift capacitively coupled noise electrode line interference paper studies noise signals band stop filter right leg driven circuit band pass filter used analog signal processing wavelet transform algorithm used digital signal processing ecg detected strong movement noise background results show sensor advantages anti interference high fidelity fast response speed good stability
paper discusses important policies regulations supporting decentralized management harvesting utilization rainwater germany measures increasingly applied last decades development implementation specific policies regulations contributed significantly trend also work incentives development advanced technologies businesses well widespread growing implementation measures decentralized rainwater management harvesting utilization public private actors development generally associated environmental economic concerns related required adaptation changes climate demographic structures infrastructures well climate resilience including flood control drought resistance addressed supported measures assigned two focus areas decentralized rainwater harvesting utilization aiming saving precious fresh water resources centrally supplied drinking water well decentralized rainwater retention management aiming flood control protection existing infrastructures ecosystems decentralized management rainwater separation combined sewer systems source generally regarded state art basic condition sustainable municipal wastewater management
groundwater wadi man southeast mecca city high radon content emanated directly bed rock water reservoir analyzed lead polonium comparatively long lived progenies study effect continuous emanation accumulation radionuclides water emanation directly rock water may affected seasonally atmospheric temperature pressure therefore progenies reanalyzed seasonal samples wells obtained results showed activity levels ranging mbq respectively far recorded level parent radionuclide data discussed detail
background cloninger psychobiological model personality extensively applied subjects affected mood disorders mood however studies widely heterogeneous terms sample size methods assessment selection participants methods conducted systematic review literature random effects meta analysis studies comparing least two following groups adults primary mood diagnosis bipolar disorder major depressive disorder mdd unaffected siblings sib healthy subjects reporting quantitative results tridimensional personality questionnaire tpq temperament character inventory tci subgroup sensitivity meta regression analyses also conducted results high harm avoidance low self directedness consistently associated mood sib samples characterized higher scores novelty seeking self transcendence sib mdd age seemed negative effect novelty seeking positive effect harm avoidance cooperativeness self transcendence euthymic mood state associated reduced harm avoidance increased reward dependence self directedness cooperativeness limitations quality included studies varied relatively low moreover publication bias heterogeneity distribution effect sizes may also limited results conclusion high harm avoidance low self directedness may trait markers mood general high novelty seeking high self transcendence may specific future studies needed disentangle state trait effect personality dimension elsevier rights reserved
dark side organic food eskine reported participants exposed organic food became much morally judgmental much less prosocial relative participants exposed neutral comfort foods research sparked tremendous media interest based one experiment small sample size report three attempts replicate eskine using samples conferring high power preregistered analysis plans original materials across two direct replications online conceptual replication found organic food exposure little effect moral judgments confidence interval prosocial behavior mere exposure organic food probably sufficient substantially change moral behavior
rise bioinformatics direct response political difficulties faced genomics quest new biomedical innovation value bioinformatics lies role bridge promise genomics realization form health benefits western scientific elites able use close relationship state control facilitate emergence new domains compatible existing distribution epistemic power within embrace public trust incorporation bioinformatics saviour genomics integrated operation two key aspects governance field definition ownership new knowledge achieved mainly development common standards promotion values communality open access public ownership data legitimize maintain governance power publicly funded genomic science opposition industry advocating private ownership knowledge largely neutered institutions supporting science state concordat however order translation health benefits occur public trust assured genomic clinical data integrated knowledge ownership agreed upon across separate distinct governance territories scientist clinical medicine society tensions abound science seeks ways maintaining control knowledge production negotiation new forms governance institutions values clinicians patients
light recent criticism targeting planned parenthood essay turns planned parenthood comic book escape fear rich historical text considering implications underlying negotiation ideological positions context increasingly conservative society case study contend planned parenthood comic book uses generically familiar romance narrative ways appealing conservative readers situating birth control normative part ideal american however beyond normalizing white middle class heterosexual married women use planned parenthood resources domestication contraception also subtly masked normalization professionalized medicine within contemporary readers wary narrative medicalization women bodies comic book subtle representation expanded female autonomy authority also signals women health organizations might consider advancing feminist politics contemporary conservative era
prior research widely recognized neurocognitive impairment nci depression alcohol use disorders auds important negative predictors health related quality life hrqol among people living hiv plwh studies date however explored neuropsychological factors operate together affect hrqol incarcerated male plwh meeting criteria opioid dependence recruited malaysia largest prison standardized scales nci depression alcohol use disorders auds hrqol used conduct moderated mediation model explore extent depression mediated relationship nci hrqol auds using ordinary least squares regression based path analytic framework results showed increasing levels nci depression negatively associated hrqol effect nci hrqol significantly sobel mediated via depression furthermore conditional indirect effect nci hrqol via depression individuals auds significant suggesting moderated mediation effect findings disentangle complex relationship using moderated mediation model demonstrating increasing levels nci reduced hiv treatment negatively influenced hrqol via depression individuals auds highlights need future interventions target complex interplay neuropsychological factors order improve hrqol among plwh particularly incarcerated plwh auds
oral contraceptive pills ocps important element hepatitis virus hcv treatment women childbearing potential studies evaluated safety pharmacokinetic interactions elbasvir ebr grazoprevir gzr ethinyl estradiol levonorgestrel lng studies open label single site two period fixed sequence one way interaction studies period subjects received one tablet lng period subjects received ebr daily days gzr daily days one tablet lng day gzr group ebr group study enrolled healthy nonsmoking adult females clinically meaningful effect multiple doses ebr gzr pharmacokinetics lng geometric mean ratios gmrs auc max presence absence ebr lng confidence intervals cis contained interval similarly auc max gmrs presence absence gzr lng respectively cis auc lng max contained interval however lng auc slightly exceeded upper bound results suggest ebr gzr administered female patients hcv childbearing potential ocps prevent pregnancy
novel functionalized geotextiles prepared chemical functionalization polyethylene terephthalate pet non woven material chitosan using coating technique sodium tripolyphosphate tpp cross linking agent prepared functionalized geotextiles characterized using different surface analyses show chitosan successfully coated pet non woven materials ability prepared geotextiles remove heavy metals aqueous solution also evaluated
increasing evidence shown mirnas implicated carcinogenesis function cogenes tumor suppressor genes human cancers study confirmed mir frequently regulated cervical cancer compared normal cervical tissues ectopic expression mir suppressed proliferation migration invasion hela cervical cancer cells bioinformatics analysis revealed adp ribosylation factor like arl potential target mir remarkably regulated cervical cancer knockdown arl markedly inhibited cervical cancer cell proliferation migration invasion similarly expression mir indicating arl may function oncogene cervical cancer conclusion study revealed mir acts tumor suppressor via inhibiting proliferation migration invasion cervical cancer cells targeting arl mir arl may serve prognostic therapeutic targets cervical cancer elsevier inc rights reserved
first international definition sustainable development published within report world commission environment development common future widely known brundtland report definition states sustainable development kind development meets needs present without compromising ability future generations meet needs definition serves key element many sectors consider sustainability comes sustainable building principles building principles general definition rather complex key considerations architecture theory aesthetics technologies shape buildings function current function possibility adapt future needs construction materials used sustainability however focuses main areas ecology economics society needs order successfully address elements certain systems tools needed harmonize process building codes standards certification systems construction building complex process requires integrated approach stages project order successfully meet intention comes sustainable building particular various certification tools place help address different aspects environmental protection economy building lifecycle social aspects example accessibility functionality health paper sets overview key focus commonly known international certification systems systems compared basis importance ecology economy social energy health comfort functionality technical design integrated approach aspects analysis different priorities among systems adaptability potential baltic market serve basis research potential develop certification system local market taking account local circumstances goal development local certification system create tool straight forward criteria easily understood consumers developers investors future owners tenants state local government procurers implemented specialists building sector architects designers project managers builders authors published elsevier ltd
objectivehigh levels expressed emotions depressive symptoms often found caregivers patients anorexia nervosa parameters considered influence symptoms patient methodsone hundred seventy adolescent women caregivers assessed admission discharge year year follow evaluate symptoms patient caregivers resultsthe elevated admission decreased treatment criticism part exhibited year follow caregivers severely ill patients reported significantly greater levels mothers affected fathers interrelated conclusioncaregivers adolescent patients suffer elevated levels studies needed examine whether therapeutic interventions reduce caregivers might positive influence treatment outcome copyright john wiley sons ltd eating disorders association
current underground mining scenario inclining towards mechanized drilling blasting since proves advantageous many ways like controlled excavation profile limited ground vibrations better ground control higher rates advance enhanced mine development rates besides maintaining balance overall economics project considering challenges posed varied geological conditionsencountered mining civil engineering excavations application mechanized drilling blasting technique still dominates order meet existing mineral demands development rates need maximized attain development rates increased drill requirement calls uninterrupted consistent reliable drill system place drilling affected uncontrollable parameters like geological properties rock structure situ stresses controllable parameters like thrust rpm feed flushing operator skill working conditions etc different rock drillability models reviewed paper understand influence various key parameters influencing drill rates however interesting note many drillability models consider geology rock drillability machine design operational bit parameters situ stresses working conditions together case study underground hard rock mine presented describing mechanized drilling system development heading dimension width height using rotary percussive electro hydraulic drill jumbo order meet development rate meters per annum single mine drill bits alone costs around lacs apart drilling expenses fact huge capital investment industry stresses detailed research area development comprehensive generalized model accounting key influencing variables
south africa developing country predicted severely impacted physical water scarcity order avert future water crisis country needs find ways reduce reliance conventional surface water schemes based impoundments rivers rainwater harvesting rwh alternative water resource date viability domestic rwh within urban setting adequately considered purpose study thus address omission detailed modelling representative catchment liesbeek river catchment cape town comprising domestic properties suburbs covering area around chosen purpose new computational tool urban rainwater stormwater harvesting model urshm developed take best advantage available data analysis showed rwh economically viable minority property owners climate change likely limited impact performance rwh systems contrary claims rwh unreliable means attenuating peak stormwater flows
paper basis new method diagnosis electric motor presented first model bldc motor developed important steps build presented model considers electromagnetic behavior well mechanical faults theoretical calculation verified fem model finally simulation results presented
challenge developing computer programming visual language sphere interdisciplinary research cybernetics philosophy particular philosophy mathematics philosophy language new area philosophical analysis philosophy information consider aspect language thinking stages developing interaction person information environment means programs set problem concerning necessity find ways constructing software nonprofessionals offer efficient way eliminate distinction system interface software programming language via using visual programming language tool people communicate machine designate prospects using visual programming languages difficulties creation implementation conclude developing cloud technologies opens new opportunities make cross subject tools creating changing software functionality people without professional qualifications programming noted developing using visual languages considerable impact development nano bio info cogno technologies nbic well research field cognitive management artificial intelligence modeling visual thinking research areas recommend understanding use visual programming languages social philosophical psychological aspects
paper proposes design evaluation methodologies remote human machine interface hmi system motor winding machines electric motor interior rotor evaluates system performance motor winding machine degree freedom motion space controlled motion control kernel imp real time data motor winding status crucial ensuring quality reliability detecting malfunction facilitates development control mass production electric motors hence real time monitoring interface essential paper presents labview based hmi transfers winding statuses winding machine remote clients internet web based real time user friendly graphical interface employs lab view transfer medium proposed implement information exchange platform real time experimental results published website examination qualified end users illustrative schemes demonstration video provided comprehensive understanding
nowadays serious games play outstanding role adoption competencies since provide immersion fun motivation high level engagement among user implementation phenomena based learning correct implementation extremely important ensure high level adoption competencies users games focus research oriented achieve correct implementation requirements production short serious games article presents model based upon requirements traceability inspections verify validate correct implementation requirements successful production quality short serious games
paper novel translinear loop based high performance complementary metal oxide semiconductor cmos second generation differential current conveyor dccii introduced using super source follower transistors low equivalent impedances obtained input terminals addition new voltage mode current mode first order pass filters apfs proposed highlight performance designed cmos dccii designed cmos implementation simulated hspice using ams real process parameters consumes power using power supply voltages simulation results proposed cmos dcii circuit experimental results designed apf good agreement theoretical ones
background purpose study designed evaluate effectiveness safety rivaroxaban real world practice compared effectiveness safety dabigatran warfarin stroke prevention atrial fibrillation meta analyzing observational studies methods seventeen studies included searching pubmed studies reporting comparative effectiveness safety rivaroxaban versus dabigatran rivaroxaban versus warfarin stroke prevention atrial fibrillation results overall risks stroke systematic thromboembolism rivaroxaban similar compared dabigatran stroke thromboembolism hazard ratio confidence interval significantly reduced compared warfarin hazard ratio confidence interval major bleeding risk significantly higher rivaroxaban dabigatran hazard ratio confidence interval similar warfarin hazard ratio confidence interval rivaroxaban associated increased cause mortality gastrointestinal bleeding similar risk acute myocardial infarction intracranial hemorrhage compared dabigatran compared warfarin rivaroxaban associated similar risk bleeding mortality acute myocardial infarction higher risk gastrointestinal bleeding lower risk intracranial hemorrhage conclusions systematic review meta analysis rivaroxaban effective dabigatran effective warfarin prevention stroke thromboembolism atrial fibrillation patients major bleeding risk significantly higher rivaroxaban dabigatran cause mortality gastrointestinal bleeding rivaroxaban comparable warfarin major bleeding increased risk gastrointestinal bleeding decreased risk intracranial hemorrhage
paper presents torque model ball joint like three degree freedom dof permanent magnet spherical actuator actuator features ball shaped rotor multiple poles spherical stator circumferential air core coils analytical expression magnetic field rotor obtained based laplace equation based expression properties air core stator coils lorentz force law employed study relationship rotor torque coil input currents using linear superposition expression actuator torque terms current input stator coils obtained matrix form linear expression actuator torque facilitate real time motion control actuator servo system experimental works carried measure actual magnetic field distribution rotor three diamensional space well measure actual motor torque generated actuator coils measurement results coincident analytical study rotor magnetic field distribution actuator torque expressions linearity superposition actuator torque also verified experiments
reflection type artificial dielectric substrate ads microstrip dispersive delay line ddl analog signal processing presented ddl realized nonuniformly alternating conventional ads microstrip sections linearly increasing period linear group delay constant chirp different spectral components modulated signal incur different delays proportional frequency discriminated time design guidelines provided proposed ddl demonstrated theoretically numerically experimentally fully characterized terms reflective level bandwidth group delay chirping coefficient excitation ports ddl demonstrated frequency discriminator finally compared stepped impedance ddl sinusoidal impedance ddl shown exhibit superior symmetry along smaller overall loss due dramatically mitigated radiation thereby leading superior performances various analog signal processing systems impulse delay lines real time fourier transformers compressive receivers
montelukast cysteinyl leukotriene type receptor antagonist exhibits secondary anti inflammatory properties used higher concentrations low molecular weight heparin lmwh evokes pronounced anti inflammatory effects interrupting leukocyte adhesion migration hypothesized inhalable particles containing montelukast plus lmwh release drugs sustained fashion protect lungs allergen induced inflammation large porous particles montelukast lmwh prepared using double emulsionesolvent evaporation method montelukast first encapsulated copolymer based particles using polyethylenimine porosigen resulting particles coated lmwh particles evaluated physicochemical properties respirability release profiles anti inflammatory effect optimized formulation studied ovalbumin sensitized asthmatic sprague dawley rats optimized large porous particles diameter exhibited numerous surface indentations pores showed acceptable drug entrapment efficiency montelukast adsorption efficiency lmwh demonstrated biphasic release patterns escaped uptake rat alveolar macrophages number infiltrating inflammatory cells asthmatic rat lungs treated dual drug particles fewer untreated asthmatic rat lungs similarly airway walls asthmatic animals treated dual drug particles fold thinner untreated asthmatic animals optimized formulation protects lungs methacholine induced airway hyperreactivity overall study demonstrates feasibility loading drugs montelukast lmwh inhalable particulate system establishes novel combination therapy produces sustained drug release elicits robust anti inflammatory response lungs american pharmacists association published elsevier inc rights reserved
paper study well posedness stability analysis set valued lur dynamical systems infinite dimensional hilbert spaces existence uniqueness results established called passivity condition approach uses regularization procedure term involving maximal monotone operator lyapunov stability well invariance properties considered detail addition give sufficient conditions ensuring robust stability system finite dimensional spaces theoretical developments illustrated means two examples dealing nonregular electrical circuits one partial differential equations methodology based tools set valued variational analysis
molybdenum cofactor deficiency rare autosomal recessive disorder may present neonatal period intractable seizures mistaken ischemic encephalopathy describe patient whose prenatal sonography weeks gestation revealed diffuse brain damage multiple subcortical cavities ventriculomegaly dysgenesis corpus callosum hypoplastic cerebellum enlarged cisterna magna magnetic resonance imaging mri later revealed brain atrophy multicystic encephalomalacia hypoplastic vermis cerebellum neurological examination months showed microcephaly profound mental retardation spasticity uric acid low taurine xanthine increased urine sulfite test positive diagnosis molybdenum cofactor deficiency made sulfite oxidase activity fibroblasts undetectable patient found homozygous del mocs gene first description prenatal development severe brain disruption molybdenum cofactor deficiency
syndemics occur populations experience synergistic multiplicative effects occurring epidemics proponents syndemic theory highlight importance understanding social context diseases spread cogently argue biocultural effects external stresses food insecurity water insecurity thus holistic understanding disease social vulnerability must incorporate examination emotional social effects phenomena paper response call renewed focus measuring psycho emotional psychosocial effects food insecurity water insecurity using mixed method approach qualitative interviews quantitative assessment including household demographic illness water insecurity scale household food insecurity access scale hopkins symptoms checklist research explored psycho emotional effects water insecurity food insecurity household illness women men residing three low land districts lesotho conducted february november exploratory study first examined complicated interaction water insecurity food insecurity illness understand quantify relationship occurring stresses context hiv aids second sought separate role water insecurity predicting psycho emotional stress factors food insecurity household illness asked directly water qualitative research revealed water availability access usage amount perceived water cleanliness important dimensions water insecurity creating stress respondents daily lives qualitative quantitative data show water insecurity food insecurity changing household demographics likely resulting hiv aids epidemic associated increased anxiety depression support conclusion water insecurity critical syndemic dimension lesotho together data provide compelling evidence psycho emotional burden water insecurity elsevier ltd rights reserved
aim study investigate first time effects using adipose derived mesenchymal stem cells mscs transfected episomal plasmid encoding fibroblast growth factor fgf mscsfgf providing microenvironment required angiogenic proliferation isolated rat mscs positive mesenchymal negative hematopoietic surface markers adipogenic osteogenic differentiation mscs also occurred proper culture media presence fgf conditioned medium mscsfgf confirmed western blotting pcr used selection transfected cells confirmation presence fgf mrna respectively treatment mscfgf conditioned medium significantly increased nih cell proliferation human umbilical vein endothelial cell huvec tube formation compared conditioned medium nontransfected mscs conclusion mscsfgf efficiently secreted functional fgf promoted angiogenic proliferation using mscsfgf may provide useful strategy cell therapy merge beneficial effects stem cells positive biological effects fgf various disorders especially tissue defects neurodegenerative cardiovascular diabetes endocrine pathologies remain tested preclinical clinical studies
digital proportional integral derivative control systems unknown dynamics data driven output feedback fault tolerant control ftc problem studied paper framework active ftc issue online recursive identification residual generator state observer observability canonical form plant consideration addressed problem reconfiguration data driven fault tolerant compensation controller gain properties also dealt means obtained results prefilter riccati equation related infinity control accommodate faults ensure tracking performance resulting fault tolerant compensation control scheme designed based closed loop systems therefore practical significance existing ftc methodologies developed terms open loop systems finally effectiveness proposed ftc approach validated speed control experiment motor
introductionyouths family history alcohol drug use disorders greater risk developing substance use disorders relative family histories previously reported youths elevated activity supplementary motor area sma dorsal striatum performing tasks reduced frontal white matter integrity better understanding relationships variables would provide insight frontostriatal circuitry altered youths may important contributor elevated risk methodsin study used structural equation modeling sem test interactions activity sma dorsal striatum youths task performance determine whether increased activity regions youths least partially explained reduced frontal white matter integrity indexed anterior corona radiata fractional anisotropy acetylaspartate resultsincreased dorsal striatum activity explained similar elevated sma activity youths combined contributions increased dorsal striatal activity decreased white matter integrity fully explained elevated sma activity conclusionsthese results suggest elevated frontal cortical activity youths driven increased striatal activity via downstream projections reduced white matter integrity frontal cortical projections latter likely increasing frontal cortical activity due increased energy demands required action potential propagation part ongoing longitudinal studies examine howthese frontostriatal alterations relate risk developing substance use disorders
background subclinical hypothyroidism associated adverse obstetric outcomes neurodevelopment disorders iodine deficiency excess associated however data regarding iodine nutrition status pregnant women available study aimed clarify whether iodine deficiency excess associated especially test results anti thyroid autoantibodies negative methods total women women euthyroidism early pregnancy tianjin china investigated serum thyroid stimulating hormone free thyroxine free triiodothyronine anti thyroid peroxidase antibody tpoab anti thyroid globulin antibody tgab urinary iodine uic urinary creatinine ucr concentrations measured thyroid ultrasonography performed determine thyroid echogenicity volume uic uic ucr ratio prevalence tpoab tgab positivity thyroid gland volume compared groups uic ultrasonographic features analysed subjects group negative tpoab tgab results median uic met world health organization criterion iodine sufficiency pregnant women neither uic uic ucr ratio differed significantly groups prevalence tpoab tgab positivity group significantly higher group group significantly higher group percentage subjects negative autoantibodies uic group tended higher subjects group negative autoantibodies difference statistically significant adjusted test level alpha eight subjects group negative results tpoab tgab diagnosed hashimoto thyroiditis means thyroid ultrasonography conclusions women early pregnancy tianjin iodine sufficient still risk iodine deficiency pregnancy progressed uic associated increased risk serological negative autoimmune thyroiditis uic may play role pathogenesis cases negative results autoantibodies
past entity component system ecs pattern become major design pattern used modern architectures realtime interactive systems ris paper introduce high performance wait free hash maps system access components within ecs pattern allows non locking read write operations leading highly responsive low latency data access maintaining consistent data state furthermore present centralized well decentralized approaches reducing memory demand memory intensive wait free hash maps diverse ris applications approaches gain efficiency component wise queues use atomic markup operations fast memory deletion implemented new method current ris results show approach able efficiently reduce memory usage wait free hash maps effectively factor ten still maintaining high performance furthermore derive best practices numerical results different use cases wait free hash map memory management diverse ris applications
modal identification based ambient vibration data attracted extensive attention past decades since excitation ambient vibration tests mainly environmental effects wind traffic loading artificial excitation applied signal noise ratio data acquired plays important role mode identifiability ambient vibration conditions certain modes may identifiable due low ratio paper presents study mode identifiability instrumented cable stayed bridge use acceleration response data measured long term structural health monitoring system recently developed fast bayesian fft method utilized perform output modal identification addition identifying probable values mpvs modal parameters associated posterior uncertainties obtained method likewise power spectral density modal force identified thus possible obtain modal ratio provides efficient way investigate mode identifiability three groups data utilized study first one data sets including six collected normal wind conditions four collected typhoons second one three data sets wind speeds third one blind data first two groups data used perform ambient modal identification help estimate critical value ratio deficient mode identifiable third group data used perform verification couple fundamental modes identified including ones vertical transverse directions respectively coupled directions uncertainty ratio deficient mode investigated discussed critical value modal ratio suggested evaluate mode identifiability deficient mode work presented paper could provide base vibration based condition assessment future
study evaluated clinical significance fdg pet patients interstitial lung disease ild investigating relationships fdg pet parameters clinical indicators evaluating prognostic implications fdg pet results methods ninety patients men women mean age age range ild underwent fdg pet retrospectively analyzed suvmean defined mean suv less affected lung field suvtf adjusted suvmean using tissue fraction ctmean mean attenuation corresponding region interest high resolution suvmean suvtf ctmean compared ild patients age sex matched controls correlations suvmax suvmean suvtf ctmean clinical indicators including estimated percentage forced vital capacity fvc estimated percentage diffusion capacity lungs carbon monoxide dlco sialylated carbohydrate antigen krebs von den lungen surfactant protein reactive protein crp lactate dehydrogenase ldh ild sex age physiology gap index evaluated using spearman rank correlation test tukey kramer test cox proportional hazards model used univariate multivariate analyses factors associated lung transplantation free survival results suvmean suvtf ctmean significantly higher ild patients healthy controls except ctmean patients nonusual interstitial pneumonia pattern suvmean ctmean significantly correlated fvc dlco suvtf significantly correlated dlco ldh suvmax weakly correlated crp univariate analysis showed suvmean suvtf sex fvc dlco ild gap index significantly prognostic lung transplantation free survival multivariate analysis showed suvmean ild gap index independently prognostic lung transplantation free survival higher suvmean indicated poorer prognosis especially patients moderate risk based ild gap index conclusion suvmean significantly moderately correlated clinical indicators providing independent prognostic information patients ild fdg pet may helpful monitoring risk stratification ild patients
letter propose practical non linear energy harvesting model design resource allocation algorithm simultaneous wireless information power transfer swipt systems algorithm design formulated non convex optimization problem maximization total harvested power energy harvesting receivers subject minimum required signal interference plus noise ratios sinrs multiple information receivers transform considered non convex objective function sum ratios form equivalent objective function subtractive form enables derivation efficient iterative resource allocation algorithm iteration rank constrained semidefinite program sdp solved optimally sdp relaxation numerical results unveil substantial performance gain achieved resource allocation design based proposed non linear energy harvesting model instead traditional linear model
background shrimp house dust mite hdm allergies common canadians often allergies occur patient may due homology tropomyosin potentially shared proteins aim study assess frequency house dust mite sensitization shrimp allergic canadian population methods undertook retrospective chart review shrimp allergic patients outpatient allergy clinic kitchener ontario canada primary endpoint assess presence hdm sensitization population patients categorized approximate quartiles assessed severity shrimp reactions correlated shrimp skin test size hdm skin test size measured proportion patients atopic symptoms results identified shrimp allergic patients tested house dust mite patients positive skin test hdm patients shrimp skin test times likely exhibit dust mite skin test patients shrimp skin test odds patient shrimp skin test larger hdm skin test times odds patient shrimp skin test size find correlation shrimp skin test size shrimp reaction symptom grade conclusion canadian patients found large majority shrimp allergic patients sensitized hdm found patients large skin test shrimp likely large skin test hdm compared patients small skin test shrimp find correlation shrimp skin test size shrimp reaction symptom severity patients symptoms rhinitis asthma may caused house dust mite allergy
construction industry subcontracting common practice nowadays general contractors tend sublet large portions construction works subcontractors act construction management agencies words subcontractors carry actual production work general contractors organize coordinate subcontractors control works terms time cost quality construction industry since general contractors responsible owners works carded subcontractors general contractors select appropriate subcontractors work packages constitute entire project literature great number studies focus subcontractor selection practices construction industry studies mainly categorized two groups studies aim identify subcontractor selection criteria importance levels studies aim propose tools techniques methodologies subcontractor selection common point studies second category focus selecting appropriate subcontractor one work package project instance case airport construction project construction car park may one work package study selection subcontractors work packages constniction project made using genetic algorithm technique considering time cost quality performances real life construction project selected case study actual data regarding alternative subcontractors arc collected subcontractors work packages selected successfully using genetic algorithm technique authors published elsevier ltd
background cognitive impairment gradual loss one ability learn remember pay attention make decisions cognitively impaired elderly people challenging patient population dental health care professionals may higher risk developing oral health diseases authors systematically reviewed interventions effective improving dental health patients cognitive impairment described research gaps remaining types studies reviewed comprehensive search multiple databases authors identified studies published english language march authors included studies investigators evaluated oral health measures intervention patients years older cognitive impairment dementia nine full text articles met criteria inclusion results study randomized control trial whereas others lacked appropriate controls investigators studied effects dental treatments battery powered devices oral hygiene training care staff members interventions improved aspect oral health patients dementia results pronounced patients required assistance performing oral hygiene tasks poor oral health baseline conclusions practical implications basic care plan patients dementia minimum match prevention strategies recommended healthy elderly patients dental health care professionals promote oral hygiene education caregivers elderly patients cognitive impairment wide gap knowledge regarding effective methods specifically improve oral health patients dementia
governance become cornerstone addressing complex linkages multiple resources water energy food however contributions governance research interdisciplinary research projects either lacking highly controversial drawing integrated water resources management related experiences german research projects emerging developing countries demonstrate strengthen nexus related governance analyses stronger focus analyses existing useful governance strategies well conditions governance transitions governance analyses refer different types problems instead focusing single cases abstract analyses answers must based elaborate practice inter transdisciplinary research suggestions implemented level single researchers also require incentives institutional level
background recent animal human studies reveal distinct cognitive neurobiological differences opiate stimulant addictions however understanding common specific effects two classes drugs remains limited due high rates polysubstance dependence among drug users methods goal current study identify multivariate substance specific markers classifying heroin dependence amphetamine dependence using machine learning approaches participants included amphetamine mono dependent heroin mono dependent polysubstance dependent non substance dependent individuals majority substance dependent participants protracted abstinence used demographic personality trait impulsivity trait psychopathy aggression sensation seeking psychiatric attention deficit hyperactivity disorder conduct disorder antisocial personality disorder psychopathy anxiety depression neurocognitive impulsivity measures delay discounting stop signal immediate memory balloon analogue risk cambridge gambling iowa gambling tasks predictors machine learning algorithm results machine learning approach revealed substance specific multivariate profiles classified new samples high degree accuracy predictors psychopathy classifier common types addiction important dissociations emerged factors classifying often showed opposite patterns among individuals conclusions result suggest different mechanisms may underlie challenging unitary account drug addiction line work may shed light development standardized cost efficient clinical diagnostic tests facilitate development individualized prevention intervention programs elsevier ireland ltd rights reserved
clostridium difficile serious epidemiological problem particularly dangerous microorganism causing hospital infections currently treatment difficile infections use metronidazole vancomycin however patients recurrent infection difficult treat occurs fecal microbiota transplantation fmt new method used treat recurrent cdi fmt consists infusion fecal suspension healthy donor gastrointestinal tract patient cdi restore natural intestinal microflora fmt safe effective treatment recurrent cdi fmt extensively described around world date two randomized studies confirming effectiveness fmt conducted method also applied treatment diseases pseudomembranous colitis ulcerative colitis crohn disease irritable bowel syndrome review describes procedure fmt current state knowledge effectiveness fmt treatment recurrent cdi
background differentiation bipolar disorders borderline personality disorder bpd challenging owing shared features emotional dysregulation likely principal one aim assess differences emotion regulation strategies alone bpd alone comorbid methods interviewed participants previously receiving bpd diagnosis studying met dsm criteria one conditions results sample comprised bipolar disorder bpd comorbid analyses established linear trends greatest impairment emotion regulation strategies comorbid group followed bpd group lowest group specific deficits comorbid group included impulsivity difficulties goal directed behaviour accessing strategies similar linear profile quantified maladaptive cognitive emotion regulation strategies weighted catastrophizing rumination adaptive emotion regulation strategies superior bipolar group without significant differences observed comorbid bpd groups limitations reliance self report measures combined participants limits generalisability results bipolar sub type use dsm diagnoses risking artefactual comorbidity representation females groups conclusions differences emotion regulation strategies advance differentiation either bpd identify specificity differing strategies condition synergic effect comorbid conditions study findings assist development application targeted strategies either conditions crown copyright published elsevier rights reserved
permanent magnet synchronous motors pmsms widely involved electric aircrafts electric aircrafts cooling strategy pmsm still challenge designers paper proposed novel thermal management approach phase change material pcm pmsm applied actuator systems aircraft simplified model pmsm special casing packaged paraffin pcm built finite element method impact paraffin cavity configurations paraffin types transient cooling effect casings simulated analyzed conditions various heat load duty cycles different ambient temperatures results suggest replacing convectional motor casing paraffin based enclosure effective time pmsm temperature control could prolonged approximate motor works continuous mode peak temperature pmsm could decreased evidently pmsm operates periodic mode elsevier ltd rights reserved
justice research examining gender differences yielded contrasting findings study enlists advanced techniques cognitive neuroscience fmri examine gender differences brain activation patterns response procedural distributive justice manipulations integrate social role information processing justice neuroscience literature posit test gender differences neural subsystems known involved appraisal self relevant events results indicate relationship justice information processing neural activity areas representing subsystems significantly influenced gender greater activation females males consideration procedural distributive justice information addition find evidence gender distributive injustice interact influence bargaining behavior females rejecting ultimatum game offers frequently males results also demonstrate activation ventromedial prefrontal cortex vmpfc ventral striatum brain regions procedural justice evaluation associated offer rejection females males managerial implications based study support gender differences justice perceptions discussed
research addressed effects downscaling cokriging land surface temperature lst estimation actual evapotranspiration aet remote sensing images two procedures followed first applied downscaling cokriging coarse resolution lst product modis outcome daily aet medium spatial resolution obtained using surface energy balance system sebs second downscaled coarse aet map medium spatial resolution procedures resolution modis ndvi product used variable validation carried using landsat images lst derived thermal bands two procedures applied agricultural area traditional irrigation network iran obtained average lst value compared downscaled lst value reference aet estimated sebs using landsat data equal day compared downscaled aet value day rmse reference aet downscaled aet equal day reference downscaled lst study showed aet values obtained two downscaling procedures similar aet showed higher spatial variability obtained downscaled lst concluded lst large effect producing aet maps remote sensing images downscaling cokriging helpful provide daily aet maps medium spatial resolution international society photogrammetry remote sensing inc isprs published elsevier rights reserved
construction process high arch dams extremely complicated therefore optimization construction schedule essential construction management save large amount time investment costs construction simulation important tool construction schedule optimization high arch dams current studies involving construction schedule simulations concurrently consider real time construction situations site managers requirements paper real time interactive simulation proposed could solve problem real time construction process initial condition simulation actual construction parameters basis simulation parameters additionally site managers change simulation strategy dynamically enter requirements based real time construction situations simulation result different schemes optimized entropy weight method method construction simulation track rapid changes construction situations provide reasonable construction schedule increases flexibility construction simulation optimized construction scheme could effective guide site construction three dimensional model time cad model simulation process well expressed case study shows construction schedule established real time useful tool decision making
enormous increase application various heavy metals including lead commercial non commercial purposes also led enhanced occurrence effluents industries domestic discharge creating substantial environmental concerns existing techniques removal contaminants reverse osmosis ion exchange suffer disadvantages hence thrust develop efficient techniques removal ever increasing adsorption based use nanoadsorbents promising cost effective based ease operation present work furnishes detailed overview nanoadsorbents removal lead water various nanoadsorbents covered analysis include alumina anatase carbon nanotubes chitosan copper iron zinc oxide magnetite nanoclay zirconium nanoparticles review also gives insight synthesis characterization nanoadsorbents followed guidelines optimum operating parameters used removal process maximizing extent removal typical optimum conditions established based critical analysis literature contact time min optimum adsorbent dose dependent nanomaterials comparison different nanoparticles revealed titanium oxide hematite nanoparticles best giving removal efficiency lead ions sequestration mainly dependent adsorbent dose kept optimum yield adequate surface area number adsorption sites overall nanoadsorbents established yield efficient removal lead water
background platelet endothelial aggregation receptor pear membrane protein highly expressed platelets endothelial cells plays role platelet contact induced activation sustained platelet aggregation endothelial function previous reports implicate pear variant influencing risk patients coronary heart disease investigated whether genetic variation pear predicts cardiovascular outcome white population methods participants enrolled flemish study environment genes health outcomes women mean age years genotyped tagging snps pear measured baseline cardiovascular risk factors recorded cardiovascular disease incidence snps contrasted cardiovascular disease incidence minor allele heterozygotes homozygotes variant major allele homozygotes reference haplotypes carriers non carriers adjusted analyses accounted family clusters baseline covariables including sex age body mass index mean arterial pressure total hdl cholesterol ratio smoking drinking antihypertensive drug treatment history cardiovascular disease diabetes mellitus results median follow years died experienced major cardiovascular endpoint multivariable adjusted hazard ratios eight pear snps including ranged respectively hazard ratios three haplotypes frequency ranged mortality cardiovascular complications results influenced intake antiplatelet drugs nonsteroidal anti inflammatory drugs values interaction conclusions white population could replicate previous reports experimental studies obtained patients suggesting pear might susceptibility gene cardiovascular complications
computer programming commonly taught geographers part geographic information system gis courses advent neogeography big data open gis means programming skills becoming important encourage teaching programming geographers paper outlines course based around series laboratories aims provide introduction programming methods teaching assessment recommended laboratories use core spatial concepts relevant areas geographic study use open source python approach wider logistical pedagogical benefits
biologic therapy continues revolutionize treatment autoimmune disease especially rheumatology pathophysiology inflammation autoimmune disease becomes better understood therapies designed dampen response inflammatory cascades although first biologic therapies approved many years ago expanding indications new agents continue challenge traditional treatment strategies rheumatic diseases article reviews data supporting current use biologic therapies including label indications subset rheumatic diseases including rheumatoid arthritis lupus inflammatory myositis ankylosing spondylitis psoriatic arthritis vasculitis gout
background presence multiple allergies correlated worse outcomes patients undergoing hip knee arthroplasty effect allergies yet elucidated respect shoulder arthroplasty purpose hypothesis purpose study identify discrepancies shoulder arthroplasty outcomes respect reported drug allergies hypothesized patients multiple drug allergies would inferior outcomes study design cohort study level evidence methods included analysis single surgeon cases primary total shoulder arthroplasty minimum days follow cases fracture indication excluded preoperative postoperative metrics included visual analog scale vas pain forward flexion range motion simple shoulder test sst results postoperative patient satisfaction scores also collected chi square way analysis variance tukey post hoc analyses performed appropriate results total patients included allergies single allergy multiple allergies proportion females greater increasing number allergies allergies single allergies multiple allergies pearson chi preoperatively postoperatively difference found cohorts respect sst score vas score forward flexion also difference postoperative satisfaction cohorts difference cohorts identified comparing pre postoperative change sst scores vas scores forward flexion conclusion presence single multiple allergies correlated worse outcomes primary anatomic total shoulder arthroplasty
paper data aggregation gateway framework constrained application protocol coap group communications proposed framework designed improve throughput performance energy efficiency group communication monitor control multiple sensor devices collectively single user terminal consists four function blocks message analyzer group manager message scheduler data handler three informative databases client database resource database information database performs group management group communication functional block stores resources informative databases employs international standard based data structures provides interoperability heterogeneous devices used various applications implemented using java based open source framework called jcoap evaluate functions performance experiment results showed framework revealed better performance existing group communication methods terms throughput energy consumption
paper uses data life satisfaction individuals european countries study relationship subjective well affordability households electricity heating oil natural gas find energy prices statistically economically significant effects subjective well effect sizes smaller comparable effects important personal factors well effects average found individuals lowest income quartile addition effects strongest times required energy expenditures expected high empirical results consistent prediction greater fuel poverty implies greater effect energy prices well
terms capturing software requirements appropriate elicitation technique must selected mean paper makes comparison researchers software engineers see adequate technique capturing relevant information meet software requirements systematic mapping constructs researchers define good techniques presented compared practitioners opinions study identified constructs finally whittled six software engineers survey showed significant difference constructs work demonstrates divergence views researchers practitioners quality software requirement elicitation techniques results call empirical research define common way measure performance techniques support selection
ulnocarpal impingement syndrome common reason ulnar sided wrist pain athletes clinical history imaging physical examination important diagnosing formulating management plan gymnasts baseball racket playing athletes higher risk ulnocarpal impingement repetitive wrist pronation gripping overloading joint progress ulnar head chondromalacia triangular fibrocartilage complex tears lunotriquetral ligament damage treatment options impingement range rest splinting operative intervention splints limit wrist pronation supination prevent ulna driven distally lunate ulnar shortening osteotomy remains gold standard joint unloading interventions including arthroscopic debridement ulnar wafer procedure effective recovery time complication rates vary operative procedure taken consideration managing athletes elsevier inc rights reserved
background purpose study investigate effect risk factors including international normalized ratio inr well partial thromboplastin time ptt scores several outcomes including hospital length stay los extended glasgow outcome scale gose following tbi elderly population methods data retrospectively collected patients aged admitted post tbi mcgill university health centre montreal general hospital age injury severity score iss glasgow coma scale score gcs type trauma isolated tbi polytrauma including tbi initial scan results according marshall classification inr ptt scores prescriptions antiplatelet anticoagulant agents collected results results also indicated age iss gsc score effect gose score also found taking effect gose outcome effects depends ptt lower odds worse outcome taking agents ptt value goes however effect becomes significant ptt value reaches conclusion age injury severity rather antithrombotic agent intake associated adverse acute outcome gose hospitalized elderly tbi patients elsevier ltd rights reserved
chemical electrochemical formation oxide films aqueous oxalic sulfuric nitric acids concentrations galvanostatic mode different current densities certain formation potential values studied influence formation potential applied current density chemical nature involved electrolyte passivation stability behaviour oxide film capacitance also studied experimental data obtained using electrochemical impedance spectroscopy technique modeled using corresponding equivalent electrical circuits
international telecommunication union radiocommunication sector itu concluded process developing itu recommendation satellite component international mobile telecommunications advanced radio interface set techniques specified recommendation used implement efficient space terrestrial infrastructures high degree spectrum utilization lead variety benefits serve public interest including multimedia broadband service handheld portable terminals public protection disaster relief solutions paper presents standardization procedures describes technical characteristics satellite radio interfaces specified itu recommendation copyright john wiley sons ltd
study establishment complete flight information system provide airport management authorities passengers aboard aircraft departure arrival various kinds information order arrival aircraft help passengers get instant information flight management system capture aeronautical information services system real time rendering filter relevant flight information import system database providing immediate treatment working platform operate aeronautical information services system self development clearing subsystem therefore order obtain information process posted terminal display device system user interface designed easy use grab efficient flight management system database flight management system also allows users obtain authorized purpose setting automatic reception modification aircraft taking landing return flight human way information finally kinds publish messages terminal display billboards study coupled servo system linux sever platform sql database library materials exchange operational mechanism filtering required data stored database use advanced backstage management front display hence construction complete flight management system
plug play solar photovoltaic systems affordable easy install portable grid tied solar electric systems purchased installed average prosumer producing consumer combination recent technical safety analysis trends advanced industrialized nations indicate electrical regulations may allow plug play solar future shift regulations could radically alter current market study provides estimate new market plug play systems regulations updated investigating personal financial decision making americans potential savings prosumer mapped range scenarios results show total potential market represents opportunity sales retailers billion depending capital cost plug play solar systems systems would generate similar mwh year times electricity generated solar distributed solar energy would provide prosumers approximately billion year cost savings would expected increase per year year lifetime systems elsevier ltd rights reserved
operable description parallel mechanisms key automatic derivation structural analysis synthesis conformal geometric algebra introduced describe robot mechanisms paper group basis bivectors infinity infinity infinity established express position orientation characteristics joint axis union joint characteristics serial mechanisms defined via outer product operation intersection limb characteristics parallel mechanisms defined shuffle product operation respectively work new algebraic symbol algorithm end effectors characteristics proposed proved validity via two case studies rrr uru pms suitable computer aided derivation mechanisms position orientation characteristics
present assemble program greatly simplifying preparation molecular dynamics simulations polymeric systems program controlled either via command line intuitive graphical user interface runs major operating systems assemble allows creation desired system polymer chains constituent monomers packs chains box according required concentration returns files needed simulation gromacs illustrate capabilities assemble demonstrating easy preparation monomers long polyisoprene hexane heterogeneous mixture polybutadiene program summary program title assemble catalogue identifier aeze program summary url http cpc qub summaries aeze html program obtainable cpc program library queen university belfast ireland licensing provisions gnu general public license version lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language python computer workstations operating system windows linux mac ram depending molecule database size final system size console mode using gui classification external routines numpy wxpython using gui nature problem preparation complex polymeric systems molecular dynamics simulations gromacs solution method creation polymers collections using monomer units gromacs compatible force field packing multiple polymer copies box according desired concentration additional comments user manual tutorial necessary input files distributed program distribution file program mbytes therefore delivered directly download email requested instead html file giving details program obtained sent running time system dependent typically less seconds elsevier rights reserved
review summarises development emergency contraception methods provides overview currently available options effective safe back methods case non use failure regular contraception copper intrauterine contraceptive device currently effective method countries single dose levonorgestrel first line hormonal given within unprotected intercourse oral anti progestogens mifepristone ulipristal acetate promising alternatives better efficacies wider treatment window post coitus probably resulting diverse ancillary mechanisms actions education part contraceptive counselling improving access providing counter advance would promote abuse encourage risky sexual behaviours may facilitate timely use achieve best efficacy published elsevier ltd
objective medical advice head neck cancer hnc patients shown continue smoke misuse alcohol post diagnosis treatment study aimed better understand barriers facilitators health behavior change hbc hnc patients method conducted nine focus groups following standard protocol eligible patients diagnosed less three years previously primary hnc selected using maximum variability sampling gender age cancer stage smoking alcohol misuse thematic analysis conducted using nvivo software results participants mostly men years age married common law mean time diagnosis months range advanced cancer participants provided larger anticipated definition health behaviors encompassing traditional smoking drinking diet exercise protection hnc related dental hygiene skin care speech exercises using peg gaining weight main emerging theme patient engagement proactive rehabilitation informed medical team optimistic flexible seeking support needed patients primarily motivated stay proactive engage positive health behaviors order return normal life reclaim function rather prevent cancer recurrence barriers patient engagement included emotional aspects anxiety depression trauma demoralization symptoms fatigue pain lack information hbc healthcare providers authoritarian approach counseling hbc found commonalities barriers facilitators according behavior type smoking drinking protection diet exercise significance results study underlines key challenges addressing health behaviors head neck oncology including treatment related functional impairments symptom burden disease emotional toll delicate context requires health promotion strategies involving close rehabilitative support multidisciplinary team attentive many struggles patients treatments longer term recovery period health promotion hnc integrated routine clinical care target traditional hnc related behaviors emphasizing emotional functional rehabilitation key components
implicit measures racial attitudes often assess reactions images individuals infer attitudes toward entire social category however increasing amount research indicates responses individuals highly dependent context idiosyncratic features individual exemplars thus using images individuals assess beliefs whole social category may ideal across three time points predicted using images groups would mitigate influence idiosyncratic features individual targets thus provide better measurement tool assess beliefs category group members belong results revealed implicit measure presented images black white groups greater construct validity test retest reliability predictive validity compared implicit measure presented exemplars individually conclude groups provide window existing beliefs social categories
demand green energy production arising world lot emphasis laid making buildings green even small amount energy savings made contribute saving environment study idea proposed studied extract power high head water pipelines building building height considered study water flowing pipe sufficient energy run micro hydro turbine feasibility producing electrical energy energy pipe water found motivation find feasibility generating power using low cost turbine experimental setup consists micro turbine diameter coupled generator leds resistors employed validate results theoretical calculations presented using fundamental equations fluid mechanics theoretical results validated using experimental numerical results using cfd simulation addition exergy analysis carried quantify irreversibilities process system
chongming current energy system highly import dependent distributed energy system high renewable energy penetration taken consideration paper simulation model based energyplan software reference year developed represent chongming present energy structure four future scenarios propose different energy constructions observed results show reductions primary energy consumption electricity import annual operating costs well emissions realizable switching energy system high share renewable sources combining natural gas chp combined heating power preliminary discussions feasibility different renewable sources penetration analyzed calculating excess electricity production ceep estimated optimal combination generated fraction wind energy fraction moreover analyses taken account several flexible techniques needed order balance supply demand ensure grid voltage frequency stabilities result recommended three techniques excess production avoided far renewable energy input nearly elsevier ltd rights reserved
real time hybrid simulation rths modern cyber physical technique used experimental evaluation complex systems treats system components predictable behavior numerical substructure components difficult model experimental substructure therefore attractive method evaluation response civil structures earthquake wind anthropic loads paper response three story shear frame controlled tuned liquid column damper tlcd subject base excitation considered passive semi active control strategies implemented compared passive tlcd achieved reduction acceleration response main structure comparison structure without control semi active tlcd achieved reduction robust variations dynamic properties main structure addition rths implemented main structure modeled linear time invariant lti system state space representation tlcd control strategies evaluated shake table reproduced displacement virtual structure current assessment measures rths used quantify performance parameters generalized amplitude equivalent time delay target measured displacement shake table energy error using measured force prove rths described paper accurate method experimental evaluation structural control systems
chronic infection helicobacter pylori caga positive strains strongest risk factor gastric cancer caga gene encoded caga protein delivered gastric epithelial cells via bacterial type secretion undergoes tyrosine phosphorylation glu pro ile tyr ala epiya motifs delivered caga acts non physiological scaffold hub protein interacting multiple host signaling molecules notably pro oncogenic phosphatase shp polarity regulating kinase par mark tyrosine phosphorylation dependent independent manners caga mediated manipulation intracellular signaling promotes neoplastic transformation gastric epithelial cells transgenic expression caga experimental animals confirmed oncogenic potential bacterial protein structural polymorphism caga influences scaffold function may underlie geographic difference incidence gastric cancer since caga longer required maintenance established gastric cancer cells studying role caga neoplastic transformation provide excellent opportunity understand molecular processes underlying hit run carcinogenesis
parental mental health related quality life affects ability family cope adapt presence disability family member child therefore understanding variables influence parental mental health related quality life families children autism spectrum disorder important purpose study examine pathways parental mental health related quality life focusing variables parental stress children performance medical support neighbor support variables hypothesized interrelated one another directly indirectly associated parental mental health related quality life samples study parents children autism spectrum disorder aged years united states parents selected respondents interviewed telephone national survey children health item indicators selected survey used construct latent variables investigated variables structural equation modeling used analyze data results showed parental stress children performance medical support neighbor support played important roles pathways implications limitations discussed elsevier ltd rights reserved
although absolute risk pregnancy lower perimenopause due decreased fertility decreased coital frequency unintended pregnancy occurs ratios similar observed young women pregnancies occur high risk maternal complications poor outcomes miscarriage chromosomal abnormalities therefore premenopausal women receive counselling includes discussion sexual habits contraception routine health care encounters majority women age group use permanent contraception methods safe effective non contraceptive benefits contraceptive method contraindicated based age alone however estrogen containing methods reserved women without cardiovascular thrombotic risk factors levonorgestrel intrauterine system lng ius mirena particular benefits perimenopause safe use nearly women lng ius approved treatment heavy menstrual bleeding common concern perimenopause substantial literature supports use lng ius endometrial protection transition contraception hormone therapy although label united states reliable contraception used menopause confirmed either cessation menses years prior age year age two elevated follicle stimulating hormone fsh values hormonal methods least weeks sterility assumed least age spontaneous pregnancies reported women age elsevier ireland ltd rights reserved
shape memory alloys smas commonly used micro electro mechanical systems mems unique shape memory super elastic affects damping capacity smas become important smart material broad range engineering applications last year copper based smas promising alloys based obtaining price good characteristic properties shape memory alloys thin films used fast actuation applications due high surface volume ratio comparing bulk smas paper two shape memory alloys based copper proposed targets different deposition processes obtain mems different chemical composition analyzed scanning electrons microscope sem xrd edax considerations water quenching recovery heat treatments martensite variants dimensioned aspects also analyzed metallic materials metallic phases obtained heat treatment determined compare thermal influenced cases
objectives summarize synthesize growing gene environment gxe research investigating promoter region serotonin transporter gene httlpr eating disorders field overcome common limitation low sample size undertaking systematic review followed secondary data meta analysis studies identified review method systematic review articles using psycinfo pubmed embase undertaken identify studies investigating interaction httlpr environmental psychological factor related outcome variable seven studies identified systematic review complete data sets five community female two clinical female samples combined perform four secondary data analyses mpr traumatic life events predict status httlpr sexual physical abuse predict bulimic symptoms httlpr depression predict bulimic symptoms httlprx impulsiveness predict disordered eating results multiplicative model low function allele httlpr interacted traumatic life events experiencing sexual physical abuse one predict increased likelihood bulimic symptoms respectively however additive model also interaction sexual physical abuse considered independently httlpr interaction traumatic life events gxe interactions significant conclusion early promising results followed continued cross institutional collaboration order achieve large sample sizes necessary genetic research elsevier ltd rights reserved
increase global energy demand depletion fossil fuels environmental issues related current major power generation patterns proven highly effective drivers substantial shift towards renewable energy applications renewable energy sources res wind solar biomass provide reliable energy services direct benefits national local levels nowadays non interconnected islands electricity generation cost extremely high due utilization outdated autonomous power stations apss based oil fuel imports diesel electric generators objective present work investigate possibility achieving energy autonomy small tiny islands based exclusively use res reason small aegean sea island agathonisi faces serious energy water shortage problems investigated proposed system configuration includes commercial wind turbines photovoltaic panels batteries internal combustion electrical generator consuming biogas excess electricity used fresh water production via sea water desalination emphasis given detailed energy analysis basis sustainable development results obtained highlight feasibility competitiveness proposed system configuration comparison current situation international energy initiative published elsevier inc rights reserved
first narcoseries sin tetas hay paraiso las munecas mafia characterized female roles victims telemundo broadcast television network changed image including leading female roles drug dealing seemingly provokes investment traditional gender roles women turn active agent patriarchal world nevertheless protagonists defined means stereotypically feminine elements kindness sacrifice maternity concreted literal metaphorical way two analyzed narcoseries reina del sur camelia texana notwithstanding real subversive act characters order depart gender prototypes abilities analyze decide rather consider victims circumstances assume responsibility life chosen violent acts
construction green buildings differs traditional buildings terms design materials processes barriers development green buildings high cost project delay indicate productivity green building construction needs tackled study aims identify critical factors affecting productivity green building construction projects assessing likelihood impact criticality factors comparisons traditional projects achieve objective factors identified comprehensive literature review interviews industry experts questionnaire survey performed professionals experienced green building projects three postsurvey interviews also conducted results indicated workers experience technology design changes workers skill level planning sequencing work top five critical factors affecting productivity green building construction projects furthermore differences criticality technical factors green traditional projects remarkable draw practitioners attention findings study fill gap project management body knowledge green buildings also help practitioners identify specific adjustments traditional project management processes practices achieving productive delivery green buildings
due high penetration renewables strong trend towards decentralization future energy grids exhibit increasingly emergent behavior consequence new engineering approaches based decentralized decision making proposed agent hygrid project provides framework design development testing energy infrastructures however contrast approaches allows designer consider kinds energy electrical power also gas heat shown small scale scenarios developed software artifacts reusable site systems avoids redundancy otherwise created implementing software different systems closing gap simulation environments hybrid hard software test beds real site applications agent hygrid project intends demonstrate systematic seamless software development processes according tool chain already viable today
baseline holder blh circuits used widely stabilize analog output application specific integrated circuits asics high count rate applications careful design blh circuits vital overall stability analog signal processing chain asics recently observed self triggered fluctuations asic shaping circuits blh circuit feedback loop fact investigations showed methods enhancing small signal stabilities cause even worse situation resolve problem used large signal analyses study circuit stability found relatively small gain error amplifier small current non linear stage blh required enhance stability large signal analysis compromise properties blh findings verified spice simulations paper present detailed analysis blh circuits propose improved version minimal self triggered fluctuations summarize design considerations stability properties blh circuits
paper presents intercomparative study operationally produced large scale datasets describing soil moisture evapotranspiration vegetation characteristics within agricultural regions contiguous united states conus datasets developed using variety techniques including hydrologic modeling satellite based retrievals data assimilation survey field data collection objectives assess relative utility dataset monitoring crop yield variability quantitatively assess capacity predicting end season corn soybean yields examine evolution yield index correlations growing season analysis unique regards number variety examined yield predictor datasets detailed assessment water availability timing end season crop production growing season correlation results indicate conus state level soil moisture indices provide better information forecasting corn soybean yields vegetation based indices normalized difference vegetation index strength correlation corn soybean yields strongly depends interannual variability yield measured given location case study remotely derived datasets examined provide skill comparable situ field survey based data demonstrating utility remote sensing based approaches estimating crop yield
introduction myelofibrosis myeloproliferative neoplasm associated peripheral blood cytopenias marrow fibrosis splenomegaly systemic symptoms evolution refractory form acute myeloid leukemia treatment jak inhibitor significantly improves symptom burden reduces degree splenomegaly jak therapy however results modest prolongation survival halt disease progression reduce risk leukemic transformation novel agents potential alter progressive disease course urgently needed areas covered pre clinical rationale use telomerase inhibitor imetelstat patients advanced essential thrombocythemia reviewed well results initial clinical trials agent expert opinion results single institution pilot study imetelstat therapy reported indicate signal activity approach appears potential reverse bone marrow histomorphologic abnormalities induce molecular responses target malignant hematopoietic stem cell population patients results randomized multi center phase trial ongoing
innovation building information modelling bim technology provides new means predicting managing monitoring environmental impacts project construction development virtual prototyping visualisation technology paper aims provide thought provoking insights shortcomings scope existing green bim literature outlines important directions future research total green bim related papers reviewed compared green bim research centres environmental performance design papers construction stages papers building lifecycles studies concentrated development bim based tools managing environmental performance building maintenance retrofitting papers demolition papers stages suggested one stop shop bim environmental sustainability monitoring management building full life cycle considered future research future green bim tools also include three concept reduce reuse recycle sustainability analysis new development retrofitting projects system offer better integration facility operation maintenance manuals effective low carbon management use cloud based bim technology enable management building sustainability using big data also needed despite potential developments argued lack computer tools complications bim models hindering adoption green bim elsevier rights reserved
epithelial mesenchymal transition emt believed involved lung fibrosis process induced paraquat however molecular mechanism process clearly established present study investigated potential involvement emt poisoning expressions emt markers cadherin alpha smooth muscle actin alpha sma multiple time points exposure different concentrations evaluated western blot analysis following treatment emt induction observed microscopy related fibrosis genes including matrix metalloproteinase mmp matrix metalloproteinase mmp collagens type col type iii col iii also evaluated measuring mrna levels using pcr analysis signaling pathways analyzed using selective pharmacological inhibitors mapk cell migration ability evaluated scratch wound transwell assays data showed induced epithelial rle cells develop mesenchymal cell characteristics indicated significant decrease epithelial marker cadherin significant increase extracellular matrix ecm marker alpha smooth muscle actin dose time dependent manner moreover treated rle ntcells emt like phenotype elevated expression mmp mmp col col iii enhanced migration ability signal pathway analysis revealed induced emt led erk smad phosphorylation activation mapk pathway results current study indicate induced pulmonary fibrosis occurs via emt mediated mapk pathway implies mapk pathway promising therapeutic target alveolar epithelial cells wiley periodicals inc
uniformly distributed uncertainty exists industrial process additive error introduced quantization example able handle additive uniform gaussian measurement uncertainty simultaneously system identification flat topped gaussian distribution considered paper alternative gaussian distribution incorporate type uncertainty maximum likelihood estimation framework explicit form density function necessity work proposes approach obtaining functional structure corresponding parameter estimation flat topped gaussian distribution moment fitting strategy performance proposed approximation function verified comparison flat topped gaussian distributed random variable different gaussian uniform components results numerical simulations industrial applications system identification presented verify effectiveness flat topped gaussian distribution noise distribution handling additional uniform uncertainty
unlike world hiv incidence former soviet union continues rise international labor migration identified potentially important contributor trend attention focused risks male migrants study uses recent household survey data examine hiv related perceptions actions migrants left behind wives armenia multivariate logistic regression analyses show migrants wives significantly likely suspect husbands extramarital sex non migrants wives analyses detect greater worries hiv infection higher likelihood spousal communication hiv matters among migrants wives compared non migrants wives differences largely explained suspicion husband extramarital sex finally difference two categories women probability consistent condom use husbands found findings interpreted within context patriarchal culture unequal gender relations armenian society reinforced male migration implications findings policies increase women awareness hiv risks associated migration ability reduce risks discussed
systematic review rugby union league injuries among players age years carried calculate probabilities match injury player season pooled estimate match injury incidence studies sufficiently similar probability player injured season ranged rugby union rugby league pooled injury incidence estimate rugby union player hours injuries irrespective need medical attention time loss player hours injuries requiring least days absence games equivalent risk injured season study heterogeneity contributed wide variation injury incidence public injury surveillance prevention systems successful reducing injury rates countries system exists
despite documented association intimate partner violence perpetration suicidal ideation studies examined prevalence correlates suicidal ideation men attending batterer intervention programs cross sectional study examined prevalence correlates suicidal ideation males court ordered batterer intervention program twenty two percent sample reported experiencing suicidal ideation within weeks prior entering batterer intervention program multiple linear regression indicated depression borderline personality disorder symptoms intimate partner violence perpetration victimization antisocial personality disorder symptoms accounted significant variance suicidal ideation results suggest symptoms depression borderline personality disorder observed males attending batterer intervention programs warrant thorough suicide risk assessment implications findings limitations study discussed
sludges generated purification water human consumption produced large volumes high environmental polluting potential sludge dewatering technique using geotextile closed systems used reduce sludge volume final disposal system allows encapsulation insulation dewatering disposal sludge allows control input output variables system also known geotextile tubes geotextile containers geotextile bags function size work presents discussion main factors influencing sludge dewatering technique applicability sludges generated water treatment plant study includes tests single filling refilling small geotextile bags equipment constructed simulate control operational conditions flow rate pumping pressure evaluated performance system according parameters proposed literature also presented results obtained indicate efficiency dewatering technique depends characteristics sludge geotextile properties study indicates importance efficiency dewatering technique geotextile closed systems reducing sludge volume final disposal
current paper provides overview history development mental health services special emphasis psychotherapy china recent epidemiological surveys revealed high prevalence rates mental disorders translate huge demand mental health care chinese government responds demand increasing number types mental health professionals delivering mental health interventions one cognitive behavioural therapy cbt due unique chinese cultural values cbt needs adapted values enhance acceptability chinese people furthermore training supervision chinese therapists require cultural adaptation therapist training supervision skills paper concludes providing specific recommendations improving quality accessibility cbt china
earlier demonstrated neurofilament rich plexus axons presumptive human auditory cortex fetal development became adult like infancy elucidate origin axons studied expression vesicular glutamate transporters vglut human auditory cortex different stages development vglut expression predominates intrinsic cortico cortical synapses vglut expression predominates thalamocortical synapses levels vglut mrna higher auditory cortex birth compared postnatal development contrast levels vglut mrna low birth increased postnatal development peak childhood began decrease adolescence vglut vglut proteins present human auditory cortex early immunohistochemistry revealed supra infragranular layers immunoreactive vglut compared layer pattern maintained adulthood vglut mrna vglut synapses increased density prenatal development childhood human auditory cortex appeared undergo attrition pruning adult pattern vglut immunoreactivity dense band vglut positive terminals layer also began appear presumptive heschl gyrus density vglut positive puncta layer increased prenatal development adolescence followed decrease adulthood suggesting thalamic axons innervate human auditory cortex undergo pruning comparatively late development
peroxynitrite induced nitration cellular proteins shown associate various human pathologies expression pancreatic nitrotyrosine cellular source relative insulitis analysed cases increasing duration type diabetes compared non diabetic autoantibody negative positive cases pancreatic tail sections non diabetic autoantibody negative cases group non diabetic autoantibody positive cases group recently diagnosed cases group years diabetes group years diabetes group immunostained sequentially nitrotyrosine insulin leucocytes nitrotyrosine expression observed selective beta cells group percentage insulin positive islets nitrotyrosine ranged group minimally expressed cases present insulin positive islets cases islets case group absent case remaining cases values group nitrotyrosine absent cases positive insulin positive islets cases group values case cases absent cases consistent insulin negativity case analysis shows nitrotyrosine immunostaining independent presence severity insulitis variable nitrotyrosine expression present nonaeurodiabetic cases increased expression beta cells recent onset long standing disease requires studies determine whether beta cell nitration plays pathogenic role
paper analyses exemptions general law prism vaccine waivers united states states legally require vaccination children prior school daycare entry however obligation accompanied system medical religious philosophical exemptions nonmedical exemptions became subject discussion disneyland measles outbreak california unequivocally brought light brewing surface slow steady decline vaccination rates western societies resulting reoccurrence measles outbreaks traced back increasing public questioning vaccines growing anti vaccination movement reaction outbreak public outrage generated several states proposedand already passedbills eliminate nonmedical exemptions analyze two questions first legal exemptions mandatory childhood vaccination schemes parents opposed vaccination still justified second legal exemptions limited religious objections vaccination also granted secular objections although argument paper starts example seeks provide general philosophical reflection question exemptions mandatory childhood vaccination
objectives investigate presence immunoglobulin like transcript ilt costimulatory proteins well tumour necrosis factor tnf production antigen presenting cells apcs patients psoriatic arthritis treatment antitumour necrosis factor therapy adalimumab methods peripheral blood monocytes patients psoriatic arthritis healthy controls cultured ligand cdl stimulate differentiation apcs cell surface phenotype analysed via fluorescence activated cell sorting results cdl stimulation resulted significantly ilt monocytes cultures control subjects patients ilt positivity cdl stimulated monocytes negatively correlated disease activity patients adalimumab treatment resulted significant increases baseline ilt positivity decreases positivity monocytes patients conclusion effect adalimumab monocyte surface phenotype may due modification inflammatory milieu associated therapy induced reduction disease activity psoriatic arthritis
background although metals adversely impact children health distribution exposures many metals particularly among vulnerable subpopulations well characterized objectives sought determine whether neighborhood deprivation associated urinary concentrations thirteen metals whether observed relationships varied race ethnicity methods obtained neighborhood characteristics american community survey demographic information urine samples healthy young girls northern california obtained clinical visit urine samples analyzed metals using inductively coupled plasma mass spectrometry levels corrected creatinine ran analysis variance generalized linear regression models estimate associations urinary metal concentrations neighborhood deprivation race ethnicity stratified multivariable models evaluate possible interactions among predictors metals concentrations results urinary concentrations three metals barium lead antimony varied significantly across neighborhood deprivation quartiles four barium lead antimony tin varied across race ethnicity groups models adjusted family income cotinine race ethnicity neighborhood deprivation associated antimony concentrations neither associated lead barium tin concentrations examining neighborhood deprivation within race ethnicity groups barium levels interaction decreased neighborhood deprivation among hispanic girls trend lead levels interaction increased neighborhood deprivation among asian girls trend conclusions results indicate children vulnerability metals varies neighborhood deprivation quartile race ethnicity differential distributions exposures may contribute environmental health disparities later life published elsevier ltd
according world health organization stress significant problem times affects physical well mental health people various traditional stress detection methods available research area stress detection developed many techniques monitoring human brain used study human behavior however researches stress detection methods stress reduction methods terms technology research proposes novel method detects stress using eeg signals reduces stress introducing interventions system research uses means clustering method measure perceived stress divide subjects different categories estimate stress level proposed method useful developing products human stress reduction success implementation development research expected help reducing time consumed human power determining best solution stress management
background aims idiopathic pulmonary fibrosis ipf fatal disorder without specific treatments although efficacy intravenous immunoglobulin ivig therapy autoimmune diseases reported ipf remains unknown study aims determine efficacy safety ivig ipf methods exploratory multicenter non randomized prospective trial patients progressive ipf enrolled patients treated ivig five consecutive days day ivig monthly five consecutive months month ivig changes vital capacity diffusion capacity lung carbon monoxide dlco min walk test mwt high resolution computed tomography hrct findings evaluated results total patients ipf treated ivig day ivig month ivig group day ivig group treatment effects temporal physiological hrct findings deteriorated three six patients month ivig group changes dlco walk distance mwt months mean standard deviation respectively treatment effects long lasting change months starting ivig smaller months starting ivig cessation ivig ground glass opacities diminished two four patients adverse events mild tolerable conclusion preliminary study shows monthly ivig treatment may effective tolerable patients ipf
community opposition locally unwanted development inherently problematic destructive conflict proponents objectors escalates paper relates mixed methods findings sydney case study opposition planned affordable housing projects widespread uneven five factors identified escalated individual opposition campaigns case public notification procedures sense injustice prejudice strong campaign leadership involvement politicians argue factors likely also escalate opposition planned development forms critical social infrastructure understanding help minimise destructive conflicts proponents host communities
data reservoir parameters production rate water cut considered key parameters control matching production layer intelligent well wellbores owing complicated conditions downhole permanent downhole flowmeter installed current simple intelligent well system onshore oilfields china furthermore necessary real time data reservoir parameters production rate water cut producing layer obtained basis mass conservation equation momentum conservation equation theories heat transfer thermodynamics fluid mechanics porous medium study establishes energy conservation equation fluids tubing annulus using single point real time data pressure temperature tubing annulus temperature gradient producing layer deduced moreover temperature profile data reservoir parameters production rate water cut producing layer calculated approach used solve problem flow measurement producing layer intelligent well systems without permanent downhole flowmeters onshore chinese oilfields according production data intelligent well lei temperature distribution along wellbore analyzed water yield formation diagnosed reservoir parameters production rate water cut producing layer calculated analytic solution method agrees well conventional production logging thus indicating feasibility method realizing dynamic monitoring intelligent wells solving actual problem real time proposed method fills gaps theories intelligent well technology china elsevier rights reserved
purpose main objective study evaluate effectiveness injection plasma rich platelet derived growth factors prgf versus hyaluronic acid following arthroscopic surgery patients diagnosed internal derangement temporomandibular joint tmj osteoarthritis materials methods total patients randomised two study groups group received injection prgf group received injection mean age years range years patients women pain intensity visual analogue scale extent maximum mouth opening procedure statistically analysed results better results observed group treated prgf significant reduction pain months compared treatment regarding mouth opening increase observed groups significant difference conclusions injection prgf following arthroscopy effective injection respect pain patients advanced internal derangement tmj european association cranio maxillo facial surgery published elsevier ltd rights reserved
lightweight multi kernel architectures hpc specialized lightweight kernels lwks run side side linux compute nodes received great deal attention recently due potential addressing many challenges system software faces move towards exascale beyond lwks multi kernels implement limited set kernel functionality rest supported linux example device drivers high performance interconnects operations modern high performance interconnects driven entirely user space memory registration remote direct memory access rdma usually involves interaction linux device driver thus comes price service offloading paper introduce various optimizations multi kernel lwks eliminate memory registration cost particular propose safe rdma pre registration mechanism combined lazy memory unmapping lwk demonstrate two orders magnitude improvement rdma registration latency improvement mpi allreduce large message sizes
excessive mechanical loads induce chondrocyte apoptosis irreversible cartilage degeneration underlying molecular mechanism poorly understood aim study investigate possible role endoplasmic reticulum stress pathway hydrostatic pressure induced apoptosis rat mandibular condylar chondrocytes chondrocytes isolated rat mandibular condylar cartilage subjected cell viability apoptosis assessed cell counting kit flow cytometry assay expression stress associated molecules detected quantitative real time pcr western blot analysis addition expression apoptosis related proteins bax bcl cleaved caspase assessed western blot explore stress function chondrocytes pretreated salubrinal exposure expression type collagen aggrecan mmp adamts evaluated real time pcr results indicated reduced cell viability magnitude time dependent manner induced activation stress pathway increasing expression grp chop caspase perk peif alpha chondrocytes moreover expression bax cleaved caspase increased expression bcl decreased response stress time prolonged addition salubrinal suppressed induced apoptosis upregulated type collagen aggrecan mrna expression downregulated mmp adamts mrna expression response results demonstrate induces apoptosis mandibular condylar chondrocytes stress mediated apoptotic pathway suppression stress salubrinal prevents chondrocytes undergoing apoptosis matrix degradation induced
background use social media website twitter highly prevalent led plethora web based social health related data available use researchers researchers increasingly using data social media retrieve analyze mental health related content however limited evidence regarding people use emerging platform discuss mental health problems first place objectives aim study explore reasons individuals discuss mental health social media website twitter study first kind implement study specific hashtag research therefore also examined feasible circulate analyze study specific hashtag mental health research methods text mining methods using twitter streaming application programming interface api twitter search api used collect organize tweets hashtag whywetweetmh circulated september november tweets analyzed thematically understand key reasons discussing mental health using twitter platform results four overarching themes derived tweets collected sense community raising awareness combatting stigma safe space expression coping empowerment addition associated subthemes also identified conclusions themes derived content tweets highlight perceived therapeutic benefits twitter provision support information potential self management strategies ability use twitter combat stigma raise awareness mental health problems indicates societal benefits facilitated via platform number tweets themes identified demonstrates feasibility implementing study specific hashtags explore research questions field mental health used basis health related research
goal intrusion detection system ids monitor activities detect breaches security policies computer system network paper focuses anomaly detection paradigm ids goal anomaly based ids classify intrusion based system network activities outside normal region paper employ multiple detector set artificial immune system variation artificial immune system classify intrusion based features application layer protocols http ftp smtp etc network data flows result shows multiple detector set artificial immune system achieved detection rate false positive rate mais achieved accuracy
present study aimed determine preventative effects fermented chimonobambusa quadrangularis shoot fcqs activated carbon constipation kun ming mice fcqs loose fiber tissue structure unfermented fresh quadrangularis shoot cqs preferable relieving constipation mice fed fcqs days time consumption first black stool defecation min shorter control group min cqs group min however longer normal min bisacodyl treatment min groups gastrointestinal transit fcqs group increased compared control cqs groups however decreased compared normal bisacodyl groups observing hemotoxylin eosin stained section mice intestine demonstrated fcqs reduced injury intestinal tract resulting constipation alleviated damage caused intestinal villi effects observed cqs group furthermore fcqs also able increase serum levels motilin endothelin vasoactive intestinal peptide acetylcholinesterase compared control group kit stem cell factor scf glial cell derived neurotrophic factor gdnf mrna protein expression levels small intestinal cells fcqs fed mice increased compared cqs fed mice transient receptor potential cation channel subfamily member trpv nitric oxide synthase nos expression levels small intestinal cells fcqs fed mice reduced compared cqs fed mice findings demonstrated fcqs may induce improved preventative effects constipation compared cqs
approach avoidance model social withdrawal asendorpf identifies types social withdrawal including shyness unsociability avoidance appears uniquely associated varying indicators maladjustment emerging adulthood nelson little work done see might linked media use third decade life therefore purpose study examine longitudinally links subtypes social withdrawal connective media mail social networking problematic forms media violent video games used high amounts found linked indices maladjustment media use internalizing externalizing behaviors participants study age range time consisted undergraduate students female recruited large public universities united states completed questionnaires points time separated year results revealed avoidant individuals use problematic forms media average unsociable shy individuals furthermore problematic media use predicted withdrawn behavior time mediated relation avoidance externalizing behaviors time problems found unsociable behavior need differentiate multiple forms withdrawal emerging adulthood links problematic forms media subsequent risk factors discussed
inflammatory bowel disease ibd significant negative impact quality life qol however direct impact ibd several aspects patients lives unknown impact survey conducted europe determine impact conducted impact survey japan compared results subgroups patients ulcerative colitis crohn disease item impact survey questionnaire assessing treatment impact ibd patients lives translated japanese administered ibd patients recruited patient advocacy groups june january japanese ibd patients completed questionnaire including patients half patients satisfied treatment plan half undergone surgery satisfied outcome although patients hospitalized years hospitalized days recent flare patients reschedule appointments ibd moreover patients make adjustments working part time home avoid taking sick days patients felt lost job ibd survey results indicate ibd patients lives social activities affected deterioration qol due ibd symptoms
understanding fractions eludes many students research based knowledge fractions utility linear representation broadly influenced instruction randomized trial lesson study supported mathematical resources assigned educator teams across united states locally managed lesson study supported fractions lesson study resource kit control conditions educators elementary teachers self managed learning month period hlm analyses indicated significantly greater improvement educators students fractions knowledge teams randomly assigned lesson study resource kits results suggest integrating research based resources lesson study offers new approach problem scale combining strengths teacher leadership research based knowledge
number mobile terminals cellular interface interface growing recent years meanwhile multipath tcp mptcp enables simultaneous use multiple paths multiple tcp flows showing one regular tcp connection application standardized ietf drawn attention recently one feature mptcp realized operating system layers supporting multipath communication without modifications application however might difficult install mptcp server operating systems paper propose method applying proxy forwards tcp communication server mptcp communication mobile core network show results evaluation existing equipment
new data driven model developed determine particle size distribution psd measured fbrm chord length distribution cld data structure model consists three steps first measured clds compressed small set parameters second parameters correlated low order moments small number percentiles psd using regression models third psd low order moments used input variables two layer network sub model built predict psd form histogram two key aspects modeling strategy noteworthy namely construction specialized parameterized functions herein called generating functions reduce number parameters needed train model two layer network component well ability model size distribution demonstrate paradigm model used determine psd particles elongated morphology shown even limited data set models could trained predict psd generated laser diffraction minor size psd generated image analysis minor major psd measured image analysis elsevier ltd rights reserved
introduction adalimumab inhibitor tumor necrosis factor alpha tnf systemic non corticosteroid agent approved food drug administration fda treatment non infectious uveitis areas covered aim review summarize research demonstrated effectiveness adalimumab treatment intraocular inflammation helped establish side effect profile ultimately leading fda approval expert commentary adalimumab useful second line agent treatment non infectious uveitis approved united states use intermediate posterior panuveitis adults find effective label treatment pediatric uveitis scleritis well
variety compartment models used quantitative analysis dynamic positron emission tomography pet data traditionally models use iterative fitting method find least squares measured calculated values time may encounter problems overfitting model parameters lack reproducibility especially handling noisy data error data paper machine learning based kinetic modeling method introduced fully utilize historical reference database build moderate kinetic model directly dealing noisy data trying smooth noise image also due database presented method capable automatically adjusting models using multi thread grid parameter searching technique furthermore candidate competition concept proposed combine advantages modeling methods could find balance fitting historical data unseen target curve machine learning based method provides robust reproducible solution user independent voi based pixel wise quantitative analysis dynamic pet data
graft versus host disease represents major cause morbidity mortality allogeneic hematopoietic stem cell transplant patients growing evidence lymphocytes may play role pathogenesis acute graft versus host disease purpose retrospective cohort study evaluate efficacy rituximab containing conditioning regimens decreasing graft versus host disease allogeneic hematopoietic stem cell transplant patients received standardized tacrolimus based graft versus host disease prophylaxis regimens patients divided two cohorts based presence rtx absence rtx rituximab conditioning regimen matched major graft versus host disease risk factors incidence grade acute graft versus host disease different two groups restricting analysis recipients peripheral blood hematopoietic stem cell transplants rtx group higher incidence grade acute graft versus host disease relapse death prior day median time onset acute graft versus host disease different rtx rtx groups days respectively inhibition antigen presentation cells rituximab based conditioning regimens appear reduce incidence acute graft versus host disease allogeneic hematopoietic stem cell transplant recipients
paper present new method tuning controllers symmetric send delta ssod sampling strategy first analyze conditions produce oscillations event based systems considering ssod sampling strategy describing function tool used address problem conditions oscillations established new robustness oscillation performance measure introduced entails concept phase margin one traditional measures relative stability closed loop control systems therefore application proposed robustness measure easy intuitive method tested simulations experiments additionally java application developed aid design according results presented paper isa published elsevier ltd rights reserved
aim study investigate risk ischemic hemorrhagic stroke associated incident benzodiazepine related drug bzdr use among community dwelling individuals alzheimer disease data medalz cohort including community dwelling persons newly diagnosed finland utilized incident bzdr users identified year washout period previous use persons previous stroke excluded resulting final study sample individuals incident ischemic hemorrhagic strokes identified hospital discharge causes death registers risk stroke time bzdrs compared nonuse time cox proportional hazard models follow persons started bzdr use compared nonuse bzdr use associated increased risk stroke adjusted hazard ratio ahr confidence interval ischemic stroke ahr association bzdr use hemorrhagic stroke reach significance ahr drug use associated similar risk benzodiazepine use conclusion bzdr use associated increased risk stroke among older individuals
memory intensive implementations often require access external chip memory substantially slow field programmable gate array accelerator due memory bandwidth limitations buffering frequently reused data chip common approach address problem optimization cache architecture introduces yet another complex design space paper presents high level synthesis hls design aid automatically generates parallel multicache systems tailored specific requirements application program analysis identifies nonoverlap ping memory regions supported private caches regions shared parallel units parallelization supported coherent caches synchronization primitives also decides whether parallelization legal respect data dependencies novelty paper focus programs using dynamically allocated pointer based data structures common software engineering remain difficult analyze beyond scope overwhelming majority hls techniques date second devise high level cache performance estimation find heterogeneous configuration cache sizes maximizes performance multicache system subject chip memory resource constraint demonstrate technique three case studies applications using dynamic data structures use xilinx vivado hls exemplary hls tool show speed parallelization hls implementations insertion application specific distributed hybrid multicache architecture
parabolic trough solar power plants use thermal fluid transfer thermal energy solar radiation water steam rankine cycle order drive turbine coupled electrical generator produces electricity plants heat transfer fluid htf system necessary elements transform solar radiation heat transfer thermal energy water steam exchangers order get best possible performance rankine cycle hence thermal plant necessary thermal fluid reach maximum temperature leaving solar field also mandatory thermal fluid exceed maximum operating temperature htf degrades must noted optimal temperature thermal fluid difficult obtain since solar radiation change abruptly one moment another aim document provide model htf system used optimize control temperature fluid without interfering normal operation plant results obtained model contrasted obtained real plant
background previous small study suggested brain network activation bna novel erp based brain network analysis may diagnostic utility attention deficit hyperactivity disorder adhd study examined diagnostic capability new advanced version bna methodology larger population adults without adhd method subjects unmedicated right handed year old adults sexes without dsm diagnosis adhd collected eeg subjects performing response inhibition task nogo applied spatio temporal brain network activation bna analysis eeg data analysis produced display qualitative measures brain states bna scores providing information cortical connectivity complex set scores fed machine learning algorithm results bna analysis eeg data recorded nogo task demonstrated high discriminative capacity adhd patients controls auc specificity sensitivity condition auc specificity sensitivity nogo condition conclusions bna methodology help differentiate adhd healthy controls based functional brain connectivity data support utility tool augment clinical examinations objective evaluation electro physiological changes associated adhd results also support network based approach study adhd
purpose investigation influence patients age well established predict malignancy potential adnexal masses study conducted evaluate impact women age histopathology malignancy potential adnexal masses materials methods retrospective chart review study patients operated suspected adnexal masses included study malignancy potentials tumors divided benign least borderline univariate multivariate analyses univariate analyses calculations performed according malignancy potential age serum cancer antigen levels menopause status results total women included study median age years patients years times higher risk least borderline tumor compared younger group risk least borderline pathology calculated patients compared others multivariate analyses level years age groups defined independent variables least borderline tumor respectively conclusion study age years detected independent factor least borderline pathology adnexal masses data results might used differential diagnostic tool new combination benign malignant adnexal masses future studies
study answers following questions green buildings gbs communicate green messages occupants lastly influence occupants pro environmental behaviours first two questions answered based ideas persuasive communication two communication channels building identified active instruction face face interpersonal transmission passive instruction building previous studies investigating influences gbs occupants changing pro environmental attitudes behaviours examined lens theory planned behaviour tpb model investigate last research question framework proposed advance current knowledge incorporating tpb theoretical foundation furthermore framework helps better understand role visual persuasion design fill research gap sample questionnaires prepared future adoption
established fact almost every channel offers high level violent content object study check degree acceptance media violence also check cognitive emotional effects viewing different types violence sample subjects aged years madrid spain viewed clip different films film data collected opinion violence three viewing conditions established according degree type violence shown based berkowitz desclee brouwer action without violence socially justified violence socially unjustified violence several anovas carried revealing violence better valued attractive watching film sequences showing wiley liss inc
power grid interconnection gained attention northeast asia nea means effectively utilize abundant renewable resources mongolia paper quantifies potential economic environmental benefits deploying massive wind turbines solar mongolia power exports author uses nea wide multi region power system model formulated linear programming problem analysis considers power systems characteristics seasonal daily electric load curves nea regions simulation results show large scale mongolian renewables contribute significant reductions nea china particular benefits significant reduction coal fired generation however huge investments would required massive renewables cross boundary transmission facilities pushing electricity supply cost relevant planning organizations need carefully consider environmental opportunities economic barriers implementation paper also investigates economic impacts transmission route circuity due avoiding transmission democratic people republic korea dprk results imply modest effects circuity total system cost availability routes dprk would significantly increase benefits nea system integrating massive renewables mongolia author published elsevier ltd
forty years relational databases leading model data storage retrieval management however due increasing needs scalability performance alternative systems started developed namely nosql technology increased interest nosql technology well use case scenarios last years databases frequently evaluated compared necessary find possibilities characteristics non relational technology disclosed papers perform mostly performance evaluation using standard benchmarks nevertheless important notice real world scenarios real enterprise data function solely based performance paper gathered concise date comparison nosql engines beneficial use case scenarios software engineer viewpoint advantages drawbacks surveying currently available literature
study design retrospective observational study objective aim study determine utilization various treatment modalities management degenerative spondylolisthesis within medicare beneficiaries summary background data degenerative lumbar spondylolisthesis condition often identified symptomatic low back pain variety treatment algorithms including physical therapy interventional techniques used manage clinically significant degenerative spondylolisthesis methods study utilized national sample medicare carrier claims cohort beneficiaries new international classification diseases edition icd diagnosis code degenerative lumbar spondylolisthesis identified current procedural terminology codes used identify number procedures performed year specialty cohort results total individuals included analysis average age time initial diagnosis years within study cohort spondylolisthesis prevalent females males caucasians racial demographics beneficiaries underwent least one injection approximately one third participated physical therapy one five underwent spinal surgery one third utilize interventions greater half procedures occurred within years diagnosis ratio focal interventions transforaminal facet interventions less selective interlaminar procedures greater specialty physical medicine rehabilitation specialties anesthesiology interventional radiology neurosurgery orthopedic surgery majority physical therapy dedicated passive treatment modalities range motion exercises rather active strengthening modalities within cohort conclusion interventional techniques physical therapy frequently used treatment modalities symptomatic degenerative spondylolisthesis understanding utilization techniques important determine relative clinical efficacies optimize future health care expenditures
experimental investigations conducted study effectiveness protective coating cashew nut shell liquid cnsl coir cnsl solution applied suitably pretreated coir yarns coating concentrations optimized reduce moisture absorption microbial growth two common cellulose lignin degrading fungi aspergillus niger rhizopus stolonifer taken test organisms qualitative quantitative analyses carried tomeasure fungal growth untreated treated fibers study shows treated fibers inhibit development fugal growth fiber surface reducedmoisture absorption improved hydrophobicity treated yarns also reported increase tensile strength noticed better properties achieved explained basis selection coating methodology also interfacial features coatings coir fiber results indicate possibility future application treated fibers geotextiles better performance compared untreated counterparts
examined relationship seasonal affective disorder sad investor response firm quarterly earnings announcements results show market cumulative abnormal returns associated unexpected earnings sad investors respond negatively earnings announced fall seasons also found asymmetric sad effect significant positive earnings announcements average moreover sad affect evident stocks salient investors elsevier inc rights reserved
extensive small signal analysis voltage mode controlled interleaved dual boost idb converter operating continuous current mode based signal flow graph approach proposed small signal flow graph developed open loop small signal transfer functions derived using well known mason gain formula closed loop small signal input output control output transfer functions also derived frequency response characteristics determined different duty ratios voltage mode compensator designed using factor approach used closed loop operation idb converter load voltage regulation supply voltage load disturbances demonstrated experimental results elsevier science ltd rights reserved
study aims investigate use metacognitive online reading strategies among iraqi students research seeks answer following research questions metacognitive online reading strategies iraqi fourth year undergraduate students read online academic text difficulties faced iraqi fourth year undergraduates read online academic text using quantitative approach study deployed questionnaires administered fourth year students salam university college baghdad iraq response metacognitive online reading strategies among students assessed differently students adopt online dictionaries reading books online journal articles ways increase students reading ability enhance online reading among english foreign language efl students iraq researcher analyzed students metacognitive reading strategies usage problems based quantitative analysis students responses sors questionnaire students showed problem solving reading strategies frequently used strategy followed support reading strategies global reading strategies identified themes provide help students improve reading skills researcher recommends future research examine reading strategies online even print text moreover reading strategies taught english foreign language efl students
behavioral dysexecutive disorders highly prevalent patients neurological diseases explained cognitive dysexecutive impairments fact underlying mechanisms poorly understood given socioemotional functioning underlies appropriate behavior socioemotional impairments may contribute appearance behavioral disorders investigate issue performed transnosological study seventy five patients suffering various neurological diseases alzheimer disease parkinson disease frontotemporal lobar degeneration stroke included study patients comprehensively assessed terms cognitive behavioral dysexecutive disorders socioemotional processes facial emotion recognition theory mind seen cognitive behavioral dysexecutive impairments prevalence socioemotional impairments varied according diagnosis stepwise logistic regressions showed cognitive executive indices predicted hypoactivity apathy abulia theory mind impairments predicted hyperactivity distractibility impulsivity stereotyped perseverative behaviors iii impaired facial emotion recognition predicted social behavior disorders several dysexecutive behavioral disorders associated underlying impairment socioemotional processes cognitive indices executive functioning except apathy results strongly suggest dysexecutive behavioral disorders outward signs underlying impairment socioemotional processes
review prepared aim show role serotonin seasonal affective disorder seasonal affective disorder also called winter depression winter blues mood disorder persons normal mental health throughout year show depressive symptoms winter less commonly summer serotonin important endogenous neurotransmitter also acts neuromodulator least invasive natural researched treatment seasonal affective disorder natural otherwise light therapy negative air ionization acts liberating charged particles sleep environment also become effective treatment seasonal affective disorder
study analyzes carbon footprint internal combustion engine scooter ice four types electric scooters studied namely hydrogen fueled scooter board methanol steam reforming board smr hydrogen scooter methane steam reforming smr plug electric scooter pev hybrid scooter paper also uses sensitivity analysis examine variations fuel prices influence cost benefit using hydrogen scooter research results follows smr board smr smallest carbon pev hybrid scooter ice percentage carbon emissions relative ice scooter ascending order according iso standard capital goods fixed costs accounted total life cycle costs total life cycle costs excluding fixed costs descending order smr ice board smr hybrid scooter pev variation fuel price key factor using hydrogen scooters hydrogen energy publications llc published elsevier ltd rights reserved
present study aimed investigate association two polymorphisms protein cell division control protein rac activated kinase gene susceptibility schizophrenia scz chinese zhuang chinese han populations total patients scz healthy controls recruited polymorphisms genotyped using sequenom technology total patients completed positive negative syndrome scale panss assessment data statistically analyzed using plink version spss version chinese han population genotypic allelic frequencies untranslated region utr genetic variation patients significantly decreased compared controls frequencies significantly associated scz susceptibility additive model padj recessive model padj moreover haplotype constructed polymorphisms remained significantly associated scz risk following adjustment gender age applying bonferroni correction chinese han population adj adjacent utr genetic variation significantly associated total score adj positive scale score adj general psychopathology scale scores adj recessive model chinese han population however polymorphisms significantly associated scz susceptibility panss scores chinese zhuang population conclusion variations pak gene influenced susceptibility severity clinical symptoms scz chinese han population investigated present study
full spectrum dependent types promise enable development correct construction software however even certified software needs interact simply typed untyped programs perform system calls use legacy libraries trading static guarantees runtime checks dependent interoperability framework provides mechanism simplytyped values safely coerced dependent types conversely dependently typed programs defensively exported simply typed application paper give semantic account dependent interoperability presentation relies guided pervading notion type equivalence whose importance emphasized recent work homotopy type theory specifically develop notion partial type equivalences key foundation dependent interoperability framework developed coq thus constructive verified strictest sense terms using library users specify domain specific partial equivalences data structures library takes care sometimes heavy lifting leads interoperable programs thus becomes possible shall illustrate internalize hand tune extraction dependently typed programs interoperable ocaml programs within coq
primary impediment continued improvement traditional charge based electronic devices accordance moore law excessive energy dissipation takes place devices switching bits one promising solution utilize strain mediated multiferroic composites magnetostrictive nanomagnet strain coupled piezoelectric layer magnetization switched two stable states sub nanosecond delay expending minuscule amount energy attojoule room temperature apart devising digital memory logic multiferroic devices also utilized analog signal processing voltage amplifier first briefly review recent advances multiferroic straintronic devices show magnetostrictive nanomagnet possible achieve called landauer limit ultimate limit energy dissipation amount ktln compensating entropy loss thereby linking information thermodynamics
branch bound popular approach accelerate solution optimization problems parallelization graphics processing units gpus challenging irregular data structures poor computation communication ratio contributions paper follows develop two cuda based implementations iterative recursive systems gpus practical application scenario optimal design multi product batch plants particular example chemical engineering system ces propose implement several optimizations cuda code reducing branch divergence exploiting properties gpu memory hierarchy evaluate implementations optimizations modern gpu based system report experimental results
rare earth ions reis playing important roles modern industries however huge amount smelting water containing various types reis difficult separate often lead difficulty recovery reis water pollution environment selective adsorption effective route recover reis smelting water two adsorbents sio sio bwt prepared grafting plant tannins bayberry tannin black wattle tannin onto aminated silica prepared adsorbents exhibited high adsorption capacity four typical reis high selectivity among four reis furthermore used adsorbents easily regenerated mol hno solution indicating superior reusability
ability recursively infer mental states others explain complex behavior ambiguous social situation may called advanced theory mind atom relations two components atom cognitive affective measured behavioral level polish year olds year olds examined role age gender friendship style relations cognitive affective atom explored cognitive atom weakly moderately related affective atom across age groups females scored higher males males atom abilities differ according age scored higher cognitive atom affective tom also different aspects friendship style significant predictors atom abilities implications two atom components within gendered social context discussed foundation professionals services adolescents published elsevier ltd rights reserved
although papers documented benefits group therapeutic activities individuals dementia dearth studies investigated effects group activities persons dementia paper introduces theoretical framework studying group therapeutic recreational activity comprehensive process model group engagement assessment tool group observational measurement engagement gome also report psychometric properties assessment one hundred four persons dementia took part ten different group activities activity conducted twice random order activities observed group participants following group activity research therapeutic recreation staff members used gome assessment independently rate participants individual level measures attendance duration engagement group level measures positive negative interactions among group members reliability validity analyses comparing observer ratings group activity individual level measures attendance engagement showed good psychometric properties different measures collected group level differed respect psychometric quality present theoretical framework understand group engagement present measures could used future research practice
reported prevalence autism spectrum disorder asd increasing rapidly many parts world however data prevalence china largely missing assessed suitability modified chinese version newly developed asd screening tool modified chinese autism spectrum rating scales asrs screening asd chinese children aged years comparison social responsiveness scale srs widely used asd screening recruited parents caregivers typically developing children children asd aged years complete asrs srs evaluated validity scales discriminating children asd developing typically results showed asrs performed well srs sensitivity specificity area curve receiver operating characteristic analysis fair false negative rate results suggest asrs promising tool screening children asd general chinese population
background perinatal depression pnd overall estimated prevalence roughly untreated pnd significant negative consequences health mothers also physical emotional cognitive development children certain risk factors known predict pnd completely safe drug treatments available pregnancy breastfeeding sleep depression strongly related solid reciprocal causal relationship bright light therapy blt well tested safe treatment effective depression circadian sleep disorders methods year longitudinal observational multicentre study women recruited followed early pregnancy gestational week months delivery primary aim present study systematically explore characterize risk factors pnd prospective sleep assessment using wrist actigraphy polysomnography various sleep questionnaires bloodbased analysis potential markers perinatal period life study secondary aims explore relationship specific genetic polymorphisms pnd substudy life investigate effectiveness blt treating pnd substudy life test whether short term trial blt pregnancy prevent pnd substudy life discussion characterization specific predictive risk factors pnd may substantially contribute improve preventive medical social strategies affected women study results expected promote better understanding relationship sleep disorders development pnd confirm large sample women safety efficacy blt prevention treatment pnd
better understand epidemiology accidents affecting wheelchair users evaluated nonfatal wheelchair related accidents reported national electronic injury surveillance system neiss division united states consumer product safety commission neiss used data representative emergency departments across united states period extrapolation sample provided average national estimate wheelchair related accidents per year serious enough cause injured person seek attention emergency department significant upward trend time elderly women likely sustain injury people injured wheelchair users common causes accidents related falls tips incidents associated secondary causes ramp transfers frequently reported location falls home majority resulting injuries contusions abrasions lacerations fractures sprains strains hospitalization required cases results analysis implications rehabilitation professionals regulatory bodies wheelchair manufacturers
adult human skeleton multifunctional organ undergoing continuous remodeling homeostasis bone mass healthy adult requires exquisite balance bone resorption osteoclasts bone formation osteoblasts disturbance balance root cause various bone disorders including osteoporosis develop effective safe therapeutics modulate bone formation essential elucidate molecular mechanisms governing osteoblast differentiation activity due specialized function collagen synthesis secretion osteoblasts expected consume large amounts nutrients however studies bioenergetics building blocks osteoblasts lagging behind growth factors transcription factors genetic studies humans mice past years established wnt signaling critical mechanism stimulating osteoblast differentiation activity importantly recent studies uncovered wnt signaling directly reprograms cellular metabolism stimulating aerobic glycolysis glutamine catabolism well fatty acid oxidation osteoblast lineage cells findings therefore reveal important regulatory axis bone anabolic signals cellular bioenergetics comprehensive understanding osteoblast metabolism regulation likely reveal molecular targets novel bone therapies
caffeine neuroprotective animal models parkinson disease caffeine intake inversely associated risk association may influenced genotype grina encodes nmdaglutamate receptor subunit two placebo controlled studies detected association caffeine intake rate clinical progression except among subjects taking creatine higher caffeine intake associated rapid progression analyzed data subjects dna samples caffeine intake data available placebo controlled study creatine grina genotype associated rate clinical progression placebo group however way interaction grina genotype caffeine creatine time since baseline among subjects creatine group high levels caffeine intake among low caffeine intake grina allele associated rapid progression data indicate deleterious interaction caffeine creatine respect rate progression influenced grina genotype example genetic factor interacting environmental factors illustrates complexity gene environment interactions progression elsevier rights reserved
devise efficient algorithm symbolic calculation irreducible angular momentum spin eigenspaces within fold antisymmetrized tensor product lambda number electrons denotes atomic subshell essential step dimension reduction configuration interaction methods applied atomic many electron quantum systems algorithm relies observation eigenstate maximal eigenvalue also eigenstate equivalently well traversal eigen states using lowering operators iterative application remaining states lambda leads implicit simultaneous diagonalization detailed complexity analysis fixed increasing subshell number yields run time symbolic computer algebra implementation available online
comprehensive investigation environmental conditions carried schoolchildren houses winter summer beijing china houses divided two groups group unhealthy children houses group healthy children houses according field measurement inappropriate thermal environment contributed indoor low temperatures rhs winter dampness summer could affect childhood health beyond standard ppm situations concentration revealed poor ventilation houses group could increase risk children asthma respiratory infections indoor carbonyls vocs levels almost homes exceed guideline however integrated influence compounds noted possible adverse health effects especially child bedroom children spent time dibutyl phthalate dbp ethylhexyl phthalate dehp frequently detected svocs house dust summer average child daily intake phthalates house dust homes group significantly higher group cladosporium spp penicillium spp aspergillus spp accounted indoor airborne fungi airborne fungal levels measured rooms exceeded cfu summer high correlation airborne fungi found consequently children health could affected combined action airborne fungi results helpful evaluate design healthy housing environment schoolchildren elsevier ltd rights reserved
method silencing activity hiv retrovirus tackle extremely high variability hiv sequences mutational escape studied sequence variability vicinity selected rna interference rnai targets isolates hiv subtype russia propose using artificial rnai potential alternative traditional antiretroviral therapy prove using multiple rnai targets overcomes variability hiv isolates optimal number targets critically depends conservation target sequences total number targets conserved probability exceed least combining deep sequencing multitarget rnai may provide efficient approach cure hiv aids
pricing options fast mean reverting stochastic volatility model using singular perturbation method received considerable amount attention last two decades however easy estimate accuracy approximation payoff function smooth bounded case european call options article introduce new novel approach pricing options fast mean reverting stochastic volatility model combinations fourier analysis singular perturbation methods enable estimate accuracy easily also show method allows derive price european bermudan options fast mean reverting stochastic volatility environment jumps elsevier rights reserved
objective aim elucidate relation osteoporosis osteoarthritis arthrosis temporomandibular joint tmj background general epidemiological data support hypothesis osteoporosis inversely correlated conclusively investigated tmj materials methods group representative elderly women men randomised comprehensive population study gothenburg sweden bone mineral density established whole body dual energy ray absorptiometry dxa part health survey addition dental examinations performed including panoramic radiographs exposed overview tmj jaws year old participants women men clinical orofacial examination according rdc tmd system performed results diagnosis osteopenia osteoporosis found statistically different greater proportion women condylar alterations evaluated panoramic radiographs observed significant gender difference significant differences found proportion individuals osteopenia osteoporosis condylar radiographic alteration forty one clinically examined subjects fulfilled criteria rdc tmd diagnosis gender difference participants graded orofacial pain low chronic pain opening capacity denoted higher risk pain temporomandibular system association found clinical diagnosis rdc tmd osteopenia osteoporosis conclusion prevalence osteopenia osteoporosis appears importance radiological clinical findings tmj
programmable dual syringe pump constructed inexpensive materials syringe pump accommodate two syringes different size without modification platform unlike reported open source syringe pumps syringes dispensed independently one another without modification total cost syringe pump roughly including microcontroller roughly without
background implicit biases involve associations outside conscious awareness lead negative evaluation person basis irrelevant characteristics race gender review examines evidence healthcare professionals display implicit biases towards patients methods pubmed psychinfo psycharticle cinahl searched peer reviewed articles published march march two reviewers assessed eligibility identified papers based precise content quality criteria references eligible papers examined identify eligible studies results forty two articles identified eligible seventeen used implicit measure implicit association test fifteen subliminal priming two test biases healthcare professionals twenty five articles employed subjects design using vignettes examine influence patient characteristics healthcare professionals attitudes diagnoses treatment decisions second method included although isolate implicit attitudes recognised psychologists specialise implicit cognition way detecting possible presence implicit bias twenty seven studies examined racial ethnic biases ten biases investigated including gender age weight thirty five articles found evidence implicit bias healthcare professionals studies investigated correlations found significant positive relationship level implicit bias lower quality care discussion evidence indicates healthcare professionals exhibit levels implicit bias wider population interactions multiple patient characteristics healthcare professional patient characteristics reveal complexity phenomenon implicit bias influence clinician patient interaction convincing studies review combine iat method measuring quality treatment actual world correlational evidence indicates biases likely influence diagnosis treatment decisions levels care circumstances need investigated review also indicates may sometimes gap norm impartiality extent embraced healthcare professionals tested characteristics conclusions findings highlight need healthcare profession address role implicit biases disparities healthcare research actual care settings greater homogeneity methods employed test implicit biases healthcare needed
paper deals torque ripple minimization using degree liberty offered doubly fed induction machine employed electrical naval propulsion various strategies carried analysis reduction torques ripples torque ripples reduced either machine design control methods authors introduce new technique decrease torque ripples using control strategy simulation results experimental tests presented discussed
background year placebo controlled phase glatiramer acetate low frequency administration gala study showed glatiramer acetate three times weekly significantly reduced annualized relapse rate arr magnetic resonance imaging mri activity patients relapsing remitting multiple sclerosis patients completing phase invited open label extension objective evaluate effects early start delayed start years methods total patients completing phase received extension patients received throughout patients received placebo phase phase relapse mri disease progression safety evaluated results total patients completed years follow phase patients showed comparable arrs similar numbers gadolinium enhancing new enlarging lesions year patients showed significantly smaller changes gray matter volume patients months mean difference similar trend whole brain volume adverse events mild consistent well established glatiramer acetate safety profile conclusion conferred treatment benefit years sustained low arr lesion activity favorable safety
background primary spinal osseous tumors rare yet represent difficult treatment paradigm complexities tumor resection significant resistance chemotherapy radiation therapy geographic distribution primary spinal osseous tumors throughout world appears quite variable low incidence reported asian countries methods data cases primary spinal osseous malignant benign tumor cases diagnosed year period eastern china analyzed results cases lesion benign malignant commonest primary malignant tumors chordoma cases followed plasma cell myeloma cases common benign tumor hemangioma cases followed giant cell tumor bone cases osteoblastoma cases benign tumors affected men cases women cases malignant tumors affected men cases women mean age mean benign group years malignant group years related symptoms pain radiculopathy cord compression mass pathological fracture deformity weight loss anatomical locations included almost every vertebra spine thoracic spine common location tumors followed cervical spine lumbar spine conclusions compared similar series reported literature countries results obtained developing country different degree large series primary spinal osseous tumors may reflect fairly well real incidence provide sufficiently detailed perspective epidemiologic studies primary spinal osseous tumors eastern china
atopic dermatitis heterogeneous disease many attempts made define subsets patients based clinical characteristics however current characterization patients might adequately reflect pathophysiologic diversity within patients article reviews current biomarkers future perspectives future patients stratified based biomarker expression levels body fluids tissue genetic variants combined biomarker expression patterns new targeted therapies currently investigated clinical trials lead better identification patients benefit highly specific expensive new treatments
study presented determine substituting internal combustion engine ice electric motor powered fuel cell stack viable option increase service ceiling available light unmanned aerial vehicle uav extending first condition stack capable supplying minimum power required horizontal leveled flight altitude function uav total mass second step examines uav transport energy required reach desired service ceiling without exceeding maximum mass loaded considering hydrogen oxygen carried board particularly light pem fuel cell stack proposed suitable power source realistic system described store required amount reactant gases maintaining mass allowable limits results indicate aerodynamic characteristics uav capable ascending described fuel cell gas storage system multivariable maps include service ceiling total payload required power provided perform type analysis copyright hydrogen energy publications llc published elsevier ltd rights reserved
objectives study aims investigate efficiency single repeated greater occipital nerve gon block using lidocaine treatment triptan overuse headache toh whose importance increased lately materials methods study consecutive subjects diagnosed toh evaluated subjects randomized three groups group triptan abruptly withdrawn group triptan abruptly withdrawn single gon block performed group triptan abruptly withdrawn three stage gon block performed patients injected bilaterally total amount lidocaine stage follow number headache days per month severity pain vas number triptans used hscrp levels recorded three times pretreatment period second month post treatment fourth month post treatment compared results statistically significant difference post treatment fourth month comparison pretreatment period group compared group number headache days vas decrease triptan need group statistically significant compared group compared pretreatment fourth month post treatment hscrp levels lower group conclusions opinion repeated gon block addition discontinuation medication significant efficacy toh cases
intergroup case study compared users mental models expert design model water management system green building system incorporates constructed wetland component rainwater collection pond together recycle water use building surroundings sample consisted five building occupants cleaner users two experts involved design water management system users mental model descriptions experts design model derived depth interviews combined self constructed verified diagrams findings study suggest considerable variability user mental models could impact efficient functioning water management system recommendations improvements discussed elsevier ltd rights reserved
relational databases rdb main sources structured data government institutions businesses since databases dependent autonomous hardware software create problems data integration interoperability solutions proposed convert rdb ontology enable sharing reuse integration semantic web however proposed methods techniques remain highly technical lack research focuses empirical application methods techniques information systems domains study develops semantically exploits relational data model south african municipalities information systems service delivery combination qualitative quantitative methods used qualitative part research carried literature review online search relevant resources whereas quantitative analysis done experiments research provides case study empirical application semantic web technologies converting rdb ontology
publication gives short overview current developments modeling simulation hot rolling processes metals institute metal forming rwth aachen university based fundamentals treated part also contained conference issue features applications field fast line models fast multi stage rolling model analytical approach predicting thickness shear distribution presented addition new concept sensitivity analysis automatic differentiation introduced discussed finally applications rolling simulations field integrated computational materials engineering presented focus twip linepipe steels well aluminum
dibromoacetonitrile dban disinfection product classified potential human animal carcinogen study aimed investigating ability myeloperoxidase mpo oxidize dban cyanide vitro detection served marker possible generation free radical intermediates implicated dban induced toxicity optimum conditions oxidation dban characterized respect temperature time incubation well dban mpo potassium chloride hydrogen peroxide concentrations incubation mixtures maximum reaction velocity michaelis menten constant assessed addition sodium hypochlorite reaction mixtures significantly enhanced rate reaction addition mpo inhibitors sodium azide amino benzoic acid hydrazine indomethacin reaction mixtures significantly decreased rate dban oxidation inclusion antioxidant enzyme superoxide dismutase incubation mixtures significantly decreased rate reaction inclusion sulfhydryl compounds reduced glutathione acetylcysteine penicillamine cysteine enhanced rate dban oxidation results demonstrate ability mpo chloride ion system oxidize dban provide insight elucidation dban chronic toxicity
although person perception central virtually human social behavior ordinarily studied isolated individual perceivers conceptualizing socially distributed process opens variety novel issues addressed scattered literatures mostly outside social psychology article examines issues using series multiagent models perceivers use gossip information others social targets improve ability detect targets perform rare negative behaviors model suggests simultaneously protect influenced malicious gossip intended defame specific targets balance potentially conflicting goals using specific strategies including disregarding gossip differs personally obtained impression multiagent modeling demonstrates outcomes produced different combinations assumptions gossip suggests directions research theoretical development
whereas parental involvement consistently linked positive child outcomes throughout development parental involvement developmentally appropriate intrusive style parenting called helicopter parenting problematic child adjustment well helicopter parenting particularly harmful emerging adulthood young adults working toward developmental goals self reliance autonomy purpose study examine sex differences relation helicopter parenting autonomy support college students mental health well secondary aim explore extent ethnic differences non hispanic white hispanic associations parenting college students outcomes examined several domains mental health including dysphoria symptoms social anxiety general well sample undergraduate students mage years female european american completed measures parenting mental health well results showed higher levels helicopter parenting predicted lower levels well females whereas higher levels autonomy support predicted lower levels dysphoria symptoms social anxiety among males ethnic differences found findings highlight parents behavior continues predict child well even emerging adulthood parenting may differentially predict male female college students mental health outcomes
college critical time individuals experience transition stress may experience subthreshold clinical symptoms anxiety depression addition educational contexts offer unique opportunity serve needs diverse group students may experience additional stressors related experiences discrimination acculturative stress financial strain balancing family work school demands therefore college appears ideal time students learn evidence based skills use response anxiety depression however multiple barriers may make less likely evidence based skills services available utilized students including lack funding services available campus well concerns mental health stigma study examines preliminary acceptability effectiveness acceptance based behavioral stress anxiety management workshop university students diverse urban campus results indicate participants found workshop acceptable helpful mixed effect regression models examining symptom impairment measures preworkshop week follow week follow showed significant effect time anxious arousal general anxiety symptoms social anxiety significant effect time impairment implications future directions mindfulness acceptance based approaches educational contexts discussed
data study skin care practices emollient use four african sites collected using depth interviews focus group discussions observations respondents mothers grandmothers fathers health workers birth attendants people selling skin care products analysis included content framework analyses emollient use normative practice sites frequent application early age sites variations type emollients used reasons use similar included improving skin keeping baby warm softening strengthening joints bones shaping baby ensuring flexibility encouraging growth weight gain factors influenced emollient choice varied included social pressure cost availability deep rooted traditional norms massage associated application strong potentially damaging skin sites given widespread use emollients repeated exposure newborns first month life potential impact emollients mortality trials conducted asia needed range african settings
softwarization networks promises cost savings better scalability network functions moving functionality specialized devices commercial shelf hardware generalized computing hardware offers many degrees adjustment tuning affect performance resource utilization one adjustments interrupt moderation techniques implemented modern network interface cards operating systems using administrator optimize either lower latencies lower cpu overhead processing network traffic work analytical model allows computing relevant performance metrics like packet processing time packet loss generic virtualized network functions running commodity hardware developed applicability model shown comparing outcome measurements conducted local testbed featuring vnf acts lte serving gateway sgw based model impact factors like average packet interarrival time interarrival time distribution duration interrupt aggregation interval studied
combined suspended particle device spd vacuum glazing potential adaptive glazing low energy building application glazing transmission essential parameter determine indoor comfort level building due glazing work clearness index strong correlation glazing transmission clearness index atmospheric transmission evaluated south facing vertical plane glazing clearness index isotropic diffuse transmittance dominant one single value glazing transmission found suitable building energy calculation throughout year clearness index south facing vertical plane spd vacuum glazing transmission transparent opaque states respectively
aimthe aim study determine concordance among cockcroft gault modification diet renal disease chronic kidney disease epidemiology collaboration ckd epi equations hypothetical dosing renally cleared medications methodsa total patients prescribed least one renally cleared drugs review included study kidney function estimated using three equations compared actual prescribed dosages drug recommended dosages based kidney function calculated equations applying dosing recommendations australian medicines handbook resultsthere significant difference kidney function values estimated three equations despite good overall agreement renal drug dosing found selected potentially important discrepancies among doses rendered equations ckd epi equation non normalized body surface area greater rate concordance cockcroft gault equation modification diet renal disease equation renal drug dosing conclusionsthere need long term multi centre study diverse population define clinical effects discrepancies among equations drug dosing given greater concordance non normalized ckd epi equation cockcroft gault equation dosing recommendation kidney health australia united states national kidney disease education program dosing based either ecrcl egfr body surface area normalization removed acceptable seems suitable practicable purpose dosing non critical drugs primary care setting
paper deals method simulation stochastic responses multiconductor transmission lines mtl fluctuating parameters via theory stochastic differential equations sde mtl responses formed sets stochastic trajectories completed corresponding sample means confidence intervals mtl model based cascade connection generalized rlcg networks state variable method used formulate basic mtl model equations boundary conditions folded via modified nodal analysis mna enabling consider mtl part arbitrarily complex lumped parameter circuits finally vector stochastic differential algebraic equation sdae formulated implicit euler numerical scheme consistent ito stochastic calculus used partly verify results deterministic responses stated via methods compared mean values stochastic ones simulations performed matlab
recent years green building attracted wide attention academia industry green building projects inevitably plagued risks study attempted assess risks green building projects singapore categorizing list risk factors groups study performed questionnaire survey received responses project managers singapore risk assessment model developed using fuzzy synthetic evaluation approach using proposed model likelihood occurrence magnitude impact risk criticality risk factor group overall risk calculated inaccurate cost estimation top risk factor cost overrun risk critical risk group overall risk criticality high implying risk management still necessary green construction singapore proposed risk assessment model reliable practical professionals green building industry applied risk assessment countries studies focused risks green projects study expands knowledge literature elsevier ltd rights reserved
using person perception paradigm two studies explored interplay target males sociability competence big two personality dimensions gender role sexual orientation study showed sociable men considered likely gay competent men mediated attribution lower masculinity study target sexual orientation considered independent variable stereotype congruent condition gay sociable heterosexual competent gay men rated feminine less masculine heterosexual men whereas stereotype incongruent condition gay competent heterosexual sociable gay targets rated less feminine equally masculine across studies apparent stereotype nice gay guy uncorrelated participants attitudes toward contact gay men results discussed regard gender inversion hypothesis distinction anti gay stereotypes prejudice stereotype content model
objective mixed martial arts mma increasingly popular combative sport involving aggressive techniques present substantial injury risk examined incidence types injuries sustained mma fights compared injuries sustained boxing matches design consecutive case series setting used data post fight medical examinations bouts edmonton canada participants participants mma competitors boxers main outcome measures attending physician conducted mandatory post fight examination fighters documented nature injuries sustained results boxers significantly likely experience injury whereas mma fighters significantly likely experience injury typically contusion bruising boxers likely experience loss consciousness serious eye injury conclusions overall injury incidence mma competitors appears slightly higher boxers mma fighters experience minor contusion bruising injuries boxers likely experience serious injury concussion head trauma involving loss consciousness eye injury retinal detachment
tight gas reservoirs prominent importance among unconventional petroleum reservoirs due complicated flow dynamics gas tight porous media compressibility effects corrections applied darcy equation properly predict gas flow dynamics mean pore diameter tight rocks shales decreases ratio mean free path pore diameter known non dimensional knudsen number rises gas rarefaction effects becomes important condition slip pore surface violated proper treatments complexities attempted using classical continuum fluid mechanics kinetic theory gases approaches well known slip condition correction presented klinkenberg many researchers tried correct extend klinkenberg model beyond slip flow regime research slip condition rarefied gas low permeability simple porous media studied lattice boltzmann method new corrections klinkenberg coefficients investigated corrections allow extension klinkenberg model higher ranges knudsen numbers simulations work performed codes developed authors elsevier rights reserved
noise vibration electrical machines major concern changes machine design improve efficiency lead unacceptable vibrations tools predict vibratory acoustic performance design stage need developed improved finite element model developed analyse vibration behaviour permanent magnet synchronous motor pmsm using finite element software abaqus components subsets machine modelled validated experimental modal analysis ema performed modelling issues overcome accurate enough model reached laminated stator formed pack several steel sheets treated orthotropic material windings considered solid orthotropic part well rotor shaft assembly also verified ema bearings join rotor assembly stator represented radial springs electromagnetic forces applied whole machine model order obtain vibration response forces obtained magnetic air gap flux density obtained finite element model developed flux finally vibration response used calculate radiated noise acoustic model developed lms virtual lab results given acoustic numerical model compared sound power measurements
acute exacerbations idiopathic pulmonary fibrosis ipf defined events clinically significant respiratory deterioration unidentifiable cause carry significant mortality morbidity exact pathogenesis remains unclear possibility remains hidden infection may play role aim pilot study determine whether changes respiratory microbiota occur ipf bacterial dna extracted bronchoalveolar lavage patients stable ipf experiencing ipf hyper variable region ribosomal rna gene rrna amplified quantified pyrosequenced culture independent techniques demonstrate ipf associated increased bal bacterial burden compared stable disease highlight shifts composition respiratory microbiota ipf
provincial wide online survey conducted ascertain frequency use breastfeeding skin skin care ssc sucrose pain reduction heel lance venipuncture maternal newborn units neonatal intensive care units nicus identify barriers using strategies pain reduction invitation link electronic survey emailed nurse managers maternal newborn units nicus ontario canada completed surveys submitted results showed variable infrequent use pain reduction strategies barriers coded health care provider hcp infant parent organizational factors barriers related ssc included preference perform blood sampling without parents parental preference involved blood sampling unit cultures date policies insufficient time knowledge education staff uncomfortable performing blood sampling infants held ssc elsevier inc rights reserved
fully polynomial time approximation scheme fptas class approximation algorithms optimisation problems able deliver approximate solution within chosen ratio polynomial time generalising bird moor thinning theorem property three orderings come datatype generic strategy constructing fold based fptass greedy thinning approximation algorithms thus seen series generalisations components needed constructing fptas often natural extensions thinning algorithm design complex fptass thus made easier resulting algorithms turn simpler previous works elsevier rights reserved
study conducted embryo foeti goat days gestation divided group days group days group iii days group days group days gestation group whole embryo processed serial sections cut whereas rest groups pelvic urethra dissected tissues representative areas used study grossly days gestation pelvic urethra present form smooth cylindrical tube approximately length primordial vesicular gland bulbourethral gland appeared days gestation junction neck urinary bladder pelvic urethra junction pelvic penile urethra respectively length width height circumference pelvic urethra increased increased gestation period however length times circumference times increased maximum group group morphometrical parameters length width height circumference pelvic urethra significantly correlated age weight foetus throughout gestation period colliculus seminalis present form ridge days gestation became distinct days gestation histologically days gestation urogenital sinus present cleft cluster cells days gestation process luminization started wall pelvic urethra started first caudal part proceeded cranially four layers tunica mucosa submucosa muscularis adventitia distinct lumen lined layers stratified epitheliumin group group iii days gestation beyond distinct transitional epithelium present formation cavernous spaces started days gestation number size increased increased gestation period thickness submucosa muscularis adventitia increased advancement age foetus whereas height epithelium decreased
field activated pressure assisted synthesis fapas used prepare tib tic tial functionally gradient materials interfacial microstructure bonding strength materials mainly investigated microstructure phase composition distribution elements interface analyzed sem xrd eds shear strength micro hardness also tested results show particles tib tic composite ceramics prepared fapas fine homogeneous disperse closely metallurgical bonding forms layers mutual diffusion different elements across interfaces maximum shear strength joint reaches mpa fracture occurs interface cermet tial micro hardness sample changes gradually titanium substrate cermet maximum hardness cermet
determine whether monthly supplementation oral vitamin widely used spain calcifediol plus daily exercise could influence survival one four years surgery osteoporotic hip fracture pragmatic randomized partially single blind placebo controlled study patients admitted tertiary university hospital acute hip fracture healthy adult patients undergoing surgery osteoporotic hip fracture recruited january december patients randomized receive either monthly oral doses calcifediol hidroferol choquea placebo months postsurgery patients received calcifediol also given exercise programme placebo group received standard health recommendations primary endpoint survival year year follow also recorded new fractures medical complications anti osteoporotic treatment compliance included total patients aged years mean age years women months patients died non intervention group years surgery died intervention group non intervention group time survival curve analysis showed survival intervention group non intervention group month follow new fractures group non intervention group medical complications significant differences visit visit significant differences groups found regarding treatment compliance monthly oral supplements calcifediol plus daily exercise improved survival one year four year follow surgery osteoporotic hip fracture
physiology adult modified alterations prenatal development driven maternal environment developmental programming established embryo implants uterus affect females differently males mechanism sex specific developmental programming established known present evidence maternal regulatory signals change female embryos differently male embryos particular actions maternally derived cytokine csf day day development affected characteristics embryo day differently females males csf decreased length ifnt secretion female embryos increased length ifnt secretion male embryos analysis limited number samples indicated changes transcriptome methylome caused csf also differed female males thus sex specific programming maternal environment could occur changes secretion maternally derived regulatory molecules alter development female embryos differently male embryos
paper global operating point dependent losses induction machines studied using local transient loss formulation level flux machine operated depends operation mode inverter hence precise loss modeling inverter driven induction machines machine design stage time spatial distribution flux density influence choosing best operating point included loss scaling method developed map iron losses calculated single synchronous frequency frequencies along torque speed map modeled losses operating points compared extensive machine measurements way example effect different electrical steel grades tailored either low losses preferable magnetizability machine performance investigated
obstructive sleep apnea osa highly prevalent disease diagnostic therapeutic purposes osa divided several subgroups positional osa posa frequent subgroup described overall apnea hypopnea index ahi supine ahi least twice high compared non supine ahi aimed investigate frequency ulnar nerve entrapment neuropathy elbow unee osa patients without clinical signs symptoms ulnar neuropathy intended find sleeping position osa impact unee development fifty posa non positional osa nposa patients healthy controls without diabetes mellitus hypothyroidism rheumatic diseases cervical radiculopathy underwent nerve conduction studies found unee highly frequent osa patients significantly frequent moderate severe posa patients mild posa patients furthermore compared non positional ones unee significantly frequent moderate severe posa patients results showed severity osa positional patients correlated increased frequency unee osa patients informed predisposition unee questioned symptoms periodical controls posa patients alerted additional effect sleeping position unee necessity osa treatment emphasized
background aims evidence food components beyond gluten cause symptoms patients gluten sensitivity without celiac disease nonceliac gluten sensitivity ncgs investigated diets nutritional characteristics patients ncgs methods performed prospective observational study patients ncgs seen outpatient clinic celiac disease food intolerances university salerno italy september april study also included control subjects experienced dietitian administered validated food frequency questionnaire european prospective investigation cancer nutrition collect information amounts common foods consumed patients control subjects also completed eating attitudes test diet related disorders patients ncgs completed minnesota multiphasic personality inventory questionnaire differences frequencies patients control subjects calculated using chi square test whereas differences continuous variables calculated using student test tests tailed significance level set minnesota multiphasic personality inventory indicating high level concern health conclusions observational study found patients ncgs eat different foods healthy individuals patients consume lower levels proteins carbohydrates fiber polyunsaturated fatty acids diets routinely analyzed possibly corrected avoid nutritional deficiencies
corrosion tests conducted static conditions degrees various oxygen contents durations single crystal sintered alumina regarded model materials ceramics extremely pure dense sintered alumina exhibited intergranular corrosion identical behavior single crystal corrosion appeared proceed reaction alo dissolved oxygen nao form sodium aluminate naalo sodium aluminate dissolved liquid sodium mechanism still elucidated corrosion morphology equivalent dissolution weight loss measurement linear kinetics found constant dissolution rate degrees low oxygen content ppm significant corrosion rate could measured degrees low oxygen content order reaction kinetics respect dissolved oxygen content found
paper presents experimental setup aiming evaluating magneto mechanical damping properties thermoplastic magnetorheological elastomer mre idea system create controllable conditions similar present vehicles mechanical constructions make possible determine parameters relating mre material test stand based four samples stimulated highly effective halbach arrays upper plate test stand excited use modal shaker assure constant impact force value test enables control impact character allows automation test stand last section paper presents preliminary test conducted find resonance frequency dependence impact force system constant value magnetic field results indicate non linear behavior material therefore exclude use simple kelvin voight model based approach damping properties determination commonly used model description different materials politechnika wroclawska published elsevier rights reserved
background viral hepatitis important global health problem affects humans strategies control hepatotropic virus focused chemotherapy surveillance emerging hcv drug resistant mutants respectively hcv genotype response therapy one major interests aim research study prevalence resistant associated variants ravs naive hcv patient candidate direct acting antiviral daa therapy methods total hcv confirmed patients referred hospitals affiliated iran university medial sciences tehran iran may march enrolled cross sectional study rna extraction rflp nested pcr performed hcv genotyping genotypes strains used amplification nsb gene mutation site purified products sequenced bioinformatics software used analysis sequences results total hcv patients male mean age female mean age isolates showed resistant mutants moreover synonymous point mutation statistical analysis found significant correlation age sex genotype variables conclusion finally concluded resistant mutants hcv genotypes infected patients broader scale studies required area using larger specimens genotype groups stages treatment published elsevier ltd
hoc wireless network set nodes connected wireless links nodes cooperate forward packets source destination geographic routing position based routing become attractive solution networks since reduces routing control overhead flooded network construct routes routes discovery many geographic routing protocols designed guarantee packet delivery networks however protocols consider nodes network trustworthy allows malicious nodes violate network security disrupt packet forwarding paper propose evaluate new security approach secures geographic routing protocols variety attacks approach based use macs allow intermediate nodes verify authenticity integrity forwarded packets uses authenticated acknowledgements prevent packet dropping attacks meet node resource constraints based solution symmetric cryptography solution robust modification dropping attacks even presence compromised nodes network
rapid development computer network technology widely used various fields achieved good results network security become major obstacle affect popularity network based author practice computer network security defense many years author carries detailed analysis problems computer network security characteristics risks focuses analysis main problems viruses hackers faced computer network proposes concrete measures network security protection arrival twenty first century computer network technologies obtained rapid development human society entered age internet information computer network widely used quality life greatly improved however rapid popularization application computer network computer network security become focus many experts scholars especially taking modern internet economy network security caused great impact national economy life easily lead internet security incidents paper based author practical experience computer network security precaution many years author carries detailed analysis problems network security puts forward many measures network security precaution make efforts application computer network security
three dimensional building models essential geographic information systems play important role various urban management applications although several light detection ranging lidar data based reconstruction approaches made significant advances toward fully automatic generation building models process still tedious time consuming especially massive point clouds paper introduces new framework utilizes spatial database achieve high performance via parallel computation fully automatic building roof reconstruction airborne lidar data framework integrates data driven model driven methods produce building roof models primary structure detailed features framework composed five major components density based clustering algorithm segment individual buildings improved boundary tracing algorithm hybrid method segmenting planar patches selects seed points parameter space grows regions spatial space boundary regularization approach considers outliers method reconstructing topological geometrical information building roofs using intersections planar patches entire process based spatial database following advantages managing querying data efficiently especially millions lidar points utilizing spatial analysis functions provided system reducing tedious time consuming computation using parallel computing reconstructing building roof models improving performance
background mutations janus kinase jak myeloproliferative leukemia mpl calr highly relevant philadelphia chromosome negative myeloproliferative neoplasms methods assessing prevalence molecular mutations chinese han patients essential thrombocythemia correlating mutational profile disease characteristics phenotype results subjects studied carried jak mutation calr mutations one carried mpl mutation non mutated jak calr mpl called triple negative mutations jak exon detected patient two patients calr jak mutations comparing hematological parameters patients jak mutations patients calr mutations showed patients calr mutations younger higher platelet counts conclusion genotyping calr could useful diagnostic tool jak mpl negative since data suggest calr much prevalent mpl therefore testing calr considered patients jak negative frequency almost times mpl mutation
background quadriceps tendon autograft known effective graft anterior cruciate ligament acl reconstruction shows similar functional outcome bone patellar tendon bone bptb randomized controlled trials lesser incidence complications studies compared hamstring tendon autograft hypothesis functional outcomes technique least good technique morbidity study design cohort study level evidence methods ninety five patients underwent isolated acl reconstruction january december fifty underwent acl reconstruction surgical technique fixation method postoperative protocol used groups following parameters evaluated surgical revisions functional outcome lysholm knee injury osteoarthritis outcome score koos tegner subjective international knee documentation committee joint stability lachman pivot shift anterior knee pain shelbourne trumper score isokinetic strength descriptive statistics presented variables using student test results eighty six patients reviewed mean follow years minimum follow years reoperations group including acl revision group including acl revisions lysholm koos symptoms koos sport scores significantly better group group terms stability mean side side difference group group based measurements negative lachman component higher group group trend negative pivot shift component higher group group shelbourne trumper score groups difference groups terms isokinetic strength conclusion use graft acl reconstruction leads equal better functional outcomes use graft without affecting morbidity
steady state superconducting tokamak sst consists many distributed heterogeneous plant experiment systems viz water cooling power supplies cryogenics vacuum magnets auxiliary heating sources diagnostics front end electronics fee data acquisition systems data acquisition control systems control monitor central control system ccs machine operation distributed computing interdependent systems essential data event acquired must disciplined precise time base make relation data event various plant experiment systems easy hence important accurate precise time synchronization place two systems fulfill requirement time synchronization sst vme based timing system provides synchronization amongst various experiment systems plasma discharges works discharge control system dcs gps based time synchronization system tss caters requirement synchronization continuous operation various plant systems feeding central clock plant systems paper presents time synchronization system sst results integrated testing engineering validation various sst subsystems elsevier rights reserved
study poly pyrrole anisidine chitosan composite films electrochemically synthesized various monomers feed ratio pyrrole anisidine pyrrole anisidine platinum electrode electrochemical synthesis composite films carried via cyclic voltammetry technique characterized cyclic voltammetry sem micrographs digital images tga dsc techniques sem results indicated particle size composite decreased increasing anisidine ratio films became likely smooth morphology tga results proved film composite ratio showed highest final degradation temperature lowest weight loss compared copolymer composite films composite film higher thermal stability copolymer composite films meanwhile electrochemical studies exhibited composite film good electrochemical stability well elsevier rights reserved
particle filters pfs widely used nonlinear signal processing wireless sensor networks wsns however measurement uncertainty makes wsn observations unreliable actual case also degrades estimation accuracy pfs addition algorithm design works focus improving likelihood calculation method since pre assumed given distribution model paper propose novel method based new likelihood fusion method wsns improve estimation performance firstly use dynamic gaussian model describe nonparametric features measurement uncertainty propose likelihood adaptation method employs prior information belief factor reduce measurement noise optimal belief factor attained deriving minimum kullback leibler divergence likelihood adaptation method integrated pfs use method develop three versions adaptive pfs target tracking system using wireless sensor network simulation experimental results demonstrate likelihood adaptation method greatly improved estimation performance pfs high noise environment addition adaptive pfs highly adaptable environment without imposing computational complexity
project manager balances resource allocation using resource leveling algorithms assigning resources project activities however resource leveling ensure optimized allocation resources furthermore duration cost project may increase leveling resources objectives resource allocation optimization used research increase resource utilization decrease project cost iii decrease project duration implemented three search based software engineering algorithms multiobjective genetic algorithm multiobjective particle swarm algorithm mopso elicit nondominated sorting evolutionary strategy twelve experiments optimize resource allocation performed published case study experimental results analyzed compared form pareto fronts average pareto fronts percent increase resource utilization percent decrease project cost percent decrease project duration experimental results show mopso best technique resource optimization optimization mopso resource utilization increased project cost duration reduced
paper two lossy grounded inductor simulators giss one lossless gis including inverting type current feedback operational amplifier cfoa two resistors capacitor proposed proposed giss easily obtained commercial available active devices ads also need critical passive component matching conditions proposed lossy giss employ grounded capacitor whereas lossless one floating capacitor order show performance proposed giss number simulation experimental test results given
internet protocol spoofing serious problem internet attractive technique adversaries wish amplify network attacks retain anonymity many approaches proposed prevent spoofing attacks however address significant deployment issue filtering inefficiency caused lack deployment incentives adopters defeat attacks effectively one mechanism must widely deployed network however majority antispoofing mechanisms unsuitable solve deployment issue mechanism work separately however defensive power considerably weak insufficiently deployed coordinate partially deployed mechanisms work together demonstrate considerably superior performance creating synergy effect overcomes limited deployment therefore propose universal antispoofing uas mechanism incorporates existing mechanisms thwart spoofing attacks proposed mechanism intermediate routers utilize existing anti spoofing mechanism ascertain packet spoofed records decision packet header edge routers victim network estimate forgery packet based information sent upstream routers results experiments conducted real internet topologies indicate uas reduces false alarms compared case mechanism operates individually
maritime applications marine vessels offshore platforms need adaptive protection power system however adaptive protection yet implemented maritime sector usually adaptive protection implies existence central control unit monitors entire electrical network changes relay settings accordingly approach adequate maritime power systems paper propose decentralized adaptive protection method protection relay able identify network status without need central control unit new adaptive protection method based communication overcurrent relays equipment could affect protection system circuit breakers generators using pscad proposed method implemented test medium voltage maritime power system possess characteristics maritime applications variable generation network reconfiguration
consider variational data assimilation varda problem operational framework namely results employed analysis temperature salinity variations data collected closed semi closed seas present computing approach solve main computational kernel heart varda problem outperforms technique nowadays employed oceanographic operative software new approach obtained means tikhonov regularization provide sensitivity analysis approach also study performance terms accuracy gain computed solution provide validations two realistic oceanographic data sets elsevier inc rights reserved
trazodone antidepressant fda approved treatment depression used mental health primary care providers treatment multiple psychiatric medical conditions review describes trazodone mechanism action formulation dosage adverse effects summarizes beneficial effects trazodone treatment various psychiatric medical conditions major depression well non approved fda indications insomnia anxiety disorders posttraumatic stress disorder obsessive compulsive disorder feeding eating disorders substance use disorders behavioral disturbances associated cognitive dysfunction sexual dysfunction certain pain conditions rehabilitation acute ischemic stroke despite trazodone favorable effects treatment fda unapproved psychiatric medical conditions large randomized controlled clinical trials still needed confirm efficacy treatment multiple conditions often used clinical practice
today advances materials science technology lead better buildings improved energy efficiency indoor conditions particular attention directed towards windows glass facadesjointly known glazingssince current practices often lead huge energy expenditures related excessive inflow outflow energy need balanced energy intensive cooling heating review article outlines recent progress thermochromics deals materials whose optical properties strongly dependent temperature particular discuss oxide based thin surface coatings thin films nanoparticle composites deposited onto glass able regulate throughput solar energy luminous visible properties remain less unaltered another implementation embodies lamination materials incorporating thermochromic nanoparticles thin films nanocomposites based vanadium dioxide able change properties within narrow temperature range vicinity room temperature either reflects absorbs infrared light elevated temperatures whereas reflectance absorptance much smaller lower temperatures review outlines state art thin films nanocomposites particular attention recent developments taken place laboratories worldwide specifically first set scene discussing environmental challenges relationship glazings enters present key properties thin film form nanoparticles next part article gives perspectives manufacturing films particles point properties pure may fully adequate buildings elaborate additives antireflection layers nanostructuring protective coatings employed yield improved performance durability make glazings considerable interest building related applications finally briefly describe recent developments towards light scattering draw final conclusions
purpose investigation sertoli leydig cell tumors slcts ovary rare usually presenting virilization women second third decade life less patients older age authors present series cases sclt managed institution materials methods retrospective review performed cases ovarian slct diagnosed tertiary care institution demographic data clinical presentation pathological findings treatment modalities collected results patients diagnosed sclt year period nine patients postmenopausal time diagnosis median age years iqr years nine patients median interval years iqr since onset menopause hyperandrogenism presenting feature five median age iqr whereas postmenopausal bleeding noted two diagnosis tumor grade varied well poorly differentiated lesions eight patients received adjuvant chemotherapy disease free survival median follow months iqr months without recurrence conclusion present patient population noticeably older described literature majority postmenopausal authors knowledge largest series postmenopausal patients slct hyperandrogenism evident small sub group definitive management slct remains controversial varied prognosis risk recurrence reassuring
agbr biobr composite successfully prepared via one step ionic reaction biobr agno solution characterized multi techniques including xrd raman xps drs transient photocurrent response results indicate synthesized agbr biobr composite actually ternary system agbr biobr displays excellent photocatalytic activity rhodamine degradation due contribution agbr charge separation agbr biobr composite highest photocatalytic efficiency degradation rate min times higher pure biobr elsevier rights reserved
computational models cardiovascular physiology inform clinical decision making providing physically consistent framework assess vascular pressures flow distributions aiding treatment planning particular lumped parameter network lpn models make analogy electrical circuits offer fast surprisingly realistic method reproduce circulatory physiology complexity lpn models vary significantly account example cardiac valve function respiration autoregulation time dependent hemodynamics complex models provide insight detailed physiological mechanisms utility maximized one quickly identify patient specific parameters clinical utility lpn models many parameters greatly enhanced automated parameter identification particularly parameter tuning match non invasively obtained clinical data present framework automated tuning lumped model parameters match clinical data demonstrate utility framework application single ventricle pediatric patients norwood physiology combination local identifiability bayesian estimation maximum posteriori simplex optimization show ability automatically determine physiologically consistent point estimates parameters quantify uncertainty induced errors assumptions collected clinical data show multi level estimation updating parameter prior information sub model analysis lead significant reduction parameter marginal posterior variance first consider virtual patient conditions clinical targets generated model solutions second application cohort four single ventricle patients norwood physiology copyright john wiley sons ltd
background mediastinal thymic seminomas rare male germ cell tumors extragonadal origin appear predominately cystic appearance case presentation year old male referred department investigation mediastinal mass discovered incidentally routine chest ray patient denied symptoms including dyspnea chest pain cough fever dysphagia hemoptysis weight loss weakness past medical history remarkable orchitis undergone bilateral testicular biopsy without latter however indicating presence germ cell tumor premalignant lesion contrast enhanced chest computed tomography revealed lobulated well marginated cystic lesion anterior mediastinum differential diagnosis included mostly multilocular thymic cyst lymphoma seminoma soft tissue tumor resection mass revealed primary thymic seminoma conclusions surgical approach management tumors might reasonable considering extensive sampling mandatory gain appropriate biopsy preoperatively order securely confirm refute presence mediastinal extragonadal tumor orchitis might sign general disorder germ cells might transform time
purpose hypoglycemia diabetes strong predictor cardiovascular events high glucose reported alter connexin expression promote autophagy cardiomyocytes investigated whether low high glucose would influence connexin expression autophagy cells methods cells incubated glucose followed glucose without chloroquine autophagy inhibitor mek inhibitor pik inhibitor cells incubated glucose without inhibitors presence mannitol used controls protein expression assayed western blot apoptosis assayed flow cytometry cell proliferation determined mtt assays cytotoxicity assayed lactate dehydrogenase measurement results cytotoxicity early apoptosis increased cell proliferation decreased exposure low high glucose results reversed chloroquine aggravated connexin expression downregulated time dependent manner accompanied upregulated expression beclin akt mtor erk chloroquine suppressed autophagy reversed downregulation connexin inhibited erk activation decreased autophagy proteins expression increased connexin expression suppressed akt activated autophagy decreased connexin expression interestingly mek inhibition also increased akt expression inhibition pik led erk downregulation conclusion culturing cells low high glucose downregulated connexin promoting autophagy mechanism involving pik akt mtor mek erk signaling pathways
early childhood years period greatest significant developments ones life generally regarded basis upon rest life constructed however early years traditionally received least attention environmental education paper aimed summarize several day day activities conducted educate children early years environment environmental education educational process deals human interrelationships environment uses interdisciplinary problem solving approach value clarification environmental education aimed producing community knowledgeable biophysical environment associated problems aware solve problems enthusiastic work toward solution highlights progress knowledge understanding attitudes skills commitment environmental problems considerations environmental education help children expand ecological worldview promote active care environment explain relationship modern life style current environmental problems several types environmental education identified literature outdoor activities natural outdoor setting school gardening play based learning drawing activities activities characteristics effects children environmental related attitudes behaviors activities unique characteristics tropical coastal areas potentially used facilitate children learn nature environment recommendations childhood education practitioners future researchers discussed
sulphide bearing mill wastes ursk ore processing plant situated kemerovo region russia investigated multipurpose studies ursk mining tailings allowed determine composition wastes pore waters acid mine drainages affected groundwater electrical resistivity tomography ert used trace geoelectric zoning wastes expressed consistent change electrical resistivity zone zone layers low resistivity indicate areas pore spaces filled highly mineralized solutions high concentrations total
purpose diabetes mellitus chronic metabolic disorder often leads complications aimed correlate two complications polyneuropathy hyperactive bladder syndrome using noninvasive measures screening tests methods included female male type diabetic patients prospective study diabetic polyneuropathy evaluations conducted using douleur neuropathique questions overactive bladder oab evaluations performed using overactive bladder questionnaire oab patients also evaluated retinopathy nephropathy diabetic male female patients without oab chosen compared microvascular complications polyneuropathy retinopathy nephropathy results significant correlations oab retinopathy well oab nephropathy among diabetic patients female patients male patients however patients oab significantly likely develop polyneuropathy female patients male patients conclusions diabetic patients oab diabetic peripheral neuropathy significantly correlated correlations demonstrated using short understandable valid reliable disease specific tests without invasive measures using screening tests neurologists urologists easily diagnose complications
anthropological studies based highly polymorphic gene human leukocyte antigen hla provide useful information bone marrow donor registry forensic medicine disease association studies well infertility treatment designing peptide vaccines tumors infectious autoimmune diseases aim study determine hla hla allele frequencies unrelated lak laek individuals lorestan province iran finally compared resultswith previously described iranian population commercial hla type kits bag lich germany company used determination hla hla allele frequencies genomic dna based polymerase chain reaction sequence specific primer pcr ssp assay differences populations distribution hla hla alleles estimated chi squared test yate correction frequent hla alleles frequent hla alleles lak population hla hla least observed frequencies lak population results based hla hla allele frequencies showed lak population possesses previously reported general features iranians still unique published elsevier inc
alkaline water electrolysis awe mature hydrogen production technology exists range economic assessments available technologies advanced awes may based novel polymer based membrane concepts prime importance development comes along new configurations technical economic key process parameters awe might interest economic assessments paper presents advanced awe technology referring three different sites europe germany austria spain focus financial metrics projection key performance parameters advanced awes financial tax parameters financial analysis investor business perspective comprehensive assessment technology comprises cost analysis also financial analysis quantifying attractiveness supply market flexibility therefore based cash flow analysis comprehensible set metrics may comprise levelised cost energy respectively levelized cost hydrogen lch cost assessment net present value npv attractiveness analysis variable cost analysis market flexibility german awe site turns perform best three financial metrics lch npv though slight differences investment cost operation maintenance cost projections three sites major cost impact due electricity cost although investment cost slightly lower labor cost significantly lower spain difference outweigh higher electricity cost compared germany given assumption electrolysis operators customers directly actively participating power markets based regulatory framework three countries special case electricity cost germany lowest however electricity cost profoundly influenced political decisions well implementation economic instruments transforming electricity systems toward sustainability hardly possible improve electricity price forecasts
possibly causal relationship multiple sclerosis chronic cerebrospinal venous insufficiency recently hypothesized studies investigating chronic cerebrospinal venous insufficiency reported conflicting results employed multiple diagnostic imaging modalities across large patient control population study three complementary imaging modalities used investigate chronic cerebrospinal venous insufficiency hypothesis patients multiple sclerosis two age sex matched control groups healthy volunteers patients neurological diseases strictly blinded doppler ultrasound according original chronic cerebrospinal venous insufficiency hypothesis four dimensional flow magnetic resonance imaging venous flow head neck chest contrast enhanced magnetic resonance venography neck chest venous luminography acquired internal jugular vein stenosis evaluation also performed across modalities percentage subjects meeting ultrasound based chronic cerebrospinal venous insufficiency criteria small similar groups group wise pairwise testing four dimensional flow magnetic resonance imaging variables statistically significantly different measurement location contrast enhanced magnetic resonance venography internal jugular azygos veins statistically significant differences observed stenosis scores groups results represent compelling evidence chronic cerebrospinal venous insufficiency hypothesis multiple sclerosis
work deals surface modification lvm stainless steel ion implantation vitro study effect short term corrosion behaviour ion release order achieve high content close surface experimental set designed different implantation doses acceleration voltages angles incidence corrosion tests carried electrochemical impedance spectroscopy eis special feature paper evaluation eis data obtained critical analysis existing equivalent electrical circuits order establish adequate parameters scientific criteria propose classification corrosion response investigated surfaces demonstrated doses ion implantation equal ion acceleration voltages kev enhanced corrosion protection contrast higher ion implantation dose ion acceleration voltage kev produced worse results probably due development strain induced alpha martensite quantity relevant ions released medium determined optimized inductively coupled plasma optical emission spectrometer icp oes method shown better corrosion resistance accompanied reduction amount ions released elsevier rights reserved
effect four different mulches fruit quality quantified either directly via mineral nutrient contributions indirectly increasing nutrient uptake efficiency soil hypothesised fruit nutrient levels would increase organic mulch containing nutrients applied soil smaller increases inorganic mulch applied tree row paper concentrate changes fruit phosphorus concentrations application five treatments clean cultivated control inorganic woven geotextile fabric organic mulches compost wood chips vermi castings wood chips combination trial conducted commercial farm lourensford estate south africa october april adjacent light sandy heavier sandy silt soil mineral nutrient analyses soil leaves mulches fruit performed yield fruit size determined soil temperatures soil water status recorded hourly last two seasons concentrations increase chronologically soil leaves fruit application mulches provided additional soil sporadic increases leaves fruit occurred could always related treatment effects significant consistent increase levels vermi castings treatment heavy soil likely combination reduced irrigation volumes well treatment effect mulches resulted well established buffering soil temperatures soil water content percentage soil carbon based results study feasible apply mulches sole purpose increase levels soil leaves fruit established trees although increases noticed time time addition water temperature modifying effects mulches would differ soil textures depend mulch source increases concentrations may result yield efficiency still primary factor determining income per hectare producer decrease yield resulted mulching conditions still outweigh positive contributions mulches therefore utmost importance first adjust irrigation volumes mulch treatment advantageous properties mulching value
two recent reports melanopsin gene variations associated seasonal affective disorder sad changes timing sleep activity healthy individuals new studies deepened understanding retinohypothalamic tract translates environmental light received retina neural signals sent set nonvisual nuclei brain responsible functions sight including circadian neuroendocrine neurobehavioral regulation pathway mediates seasonal changes physiology behavior mood individual variations pathway may explain approximately north american population develops mood disorders seasonal pattern major depressive bipolar disorders seasonal pattern also known seasonal affective disorder sad components depression including mood changes sleep patterns appetite cognitive performance affected biological behavioral responses light specifically variations gene sequence retinal photopigment melanopsin may responsible significant increased risk mood disorders seasonal pattern may leading changes activity sleep timing winter retinal sensitivity sad hypothesized decreased compared controls decrements winter light levels may combine trigger depression winter outline steps new research address possible role melanopsin seasonal affective disorder including chromatic pupillometry designed measure sensitivity melanopsin containing retinal ganglion cells elsevier ltd rights reserved
investigate differences presence trigger points trps association headache related disability mood disorders people frequent episodic tension type headache tth fetth chronic tth ctth one hundred twenty two individuals tth participated clinical features headache intensity duration frequency recorded headache diary headache related disability assessed headache disability inventory trait state anxiety levels state trait anxiety inventory depression hospital anxiety depression scale trps bilaterally explored temporalis masseter suboccipital upper trapezius splenius capitis sternocleidomastoid muscles sixty two patients classified fetth whereas classified ctth individuals ctth showed higher burden headache depression fetth subjects fetth showed similar number trps total number active trps latent trps ctth total number active trps latent trps number active trps significantly associated burden headache trait anxiety higher number active trps greater physical burden headache trait anxiety level association depression observed presence active trps head neck shoulder muscles similar individuals fetth ctth associated physical burden headache trait anxiety levels independently subgroup tth
purpose review small intestinal bacterial overgrowth sibo proposed cause irritable bowel syndrome ibs however relationship subject controversy review aims provide current perspective sibo ibs hypothesis recent findings case control studies evaluating prevalence sibo ibs healthy individuals shown conflicting results moreover tests available routine clinical practice diagnose sibo valid lack sensitivity specificity hence interpreting effect interventions based tests fraught uncertainty furthermore sibo ibs hypothesis paved way assess antibiotic therapy nonconstipated ibs rifaximin nonabsorbable antibiotic showing modest significant clinical benefit however individuals tested sibo mechanism action rifaximin ibs remains elucidated preliminary data suggest rifaximin decreases microbial richness previous studies noted antibacterial interventions ibs reduce colonic fermentation improve symptoms advent rapid culture independent molecular techniques promising tool seek clarify advance understanding gut microbial function summary sibo ibs hypothesis lacks convincing evidence remains scrutiny mechanism resulting symptom improvement rifaximin treatment ibs individuals requires exploration novel molecular techniques provide exciting challenging opportunity explore host gut microbiota interaction
paper present analysis voltage amplifier needed double differential semg measurements novel simple circuit implementing active electrodes three input amplifier standalone active electrodes require inherently different differential amplifier general knowledge design scarce literature first figures merit amplifier defined decomposition input signal three orthogonal modes analysis reveals mode containing emg crosstalk components electrode reject effect finite input impedance analyzed three terminals minimum bounds interference rejection ratios due electrode input impedance unbalances two degrees freedom obtained finally novel circuit design presented including quadruple operational amplifier passive components design nearly simple branched electrode much simpler three instrumentation amplifier design providing robust emg crosstalk rejection better input impedance using unity gain buffers electrode input interference rejection limits input stage analyzed easily replicable implementation proposed circuit described together parameter design guideline adjust specific needs electrode compared established alternatives sample semg signals obtained acquired different body locations dry contacts successfully rejecting interference sources
background definitive radiation therapy head neck cancer clinically uninvolved cervical lymph nodes irradiated called elective dose order achieve control clinically occult metastases consequence high resolution diagnostic imaging occult tumor volume significantly decreased last decades since elective dose dependent occult tumor volume currently used elective dose may higher necessary bilateral irradiation neck contributes dysphagia xerostomia hypothyroidism dose dependent way dose escalation regions open window opportunity reduce toxicity improve quality life treatment methods upgrade multicenter phase iii single blinded randomized controlled trial patients treated definitive radiation therapy newly diagnosed stage squamous cell carcinoma oropharynx hypopharynx larynx eligible exclusion criteria recurrent disease oncologic surgery head neck area concomitant chemotherapy epidermal growth factor receptor inhibitors total patients randomized ratio treatment arm without escalation elective radiation dose introduction intermediate dose level selected lymph nodes radiation therapy planning fdg pet scans acquired guide risk assessment borderline sized cervical nodes treated intermediate dose level treatment given intensity modulated radiation therapy volumetric arc therapy simultaneous integrated boost using accelerated fractionation schedule fractions weeks primary endpoint normalcy diet year treatment toxicity secondary endpoint actuarial rate recurrence electively irradiated lymph nodes years treatment safety discussion objective upgrade trial investigate whether escalation elective radiation dose introduction intermediate dose level borderline sized lymph nodes treatment head neck cancer result less radiation sequelae improved quality life treatment without compromising recurrence rate electively treated neck
purpose purpose paper numerically solve problem steady mixed convection boundary layer flow past vertical flat plate embedded fluid saturated porous medium filled nanofluid non darcy equation model along mathematical nanofluid model proposed tiwari das used design methodology approach using appropriate similarity transformations basic partial differential equations transformed ordinary differential equations equations solved numerically different values nanoparticle volume fraction mixed convection non darcy parameters using bvpc function matlab stability analysis also performed findings numerical results obtained reduced skin friction heat transfer velocity temperature profiles results indicate dual solutions exist opposing flow case lambda stability analysis indicates opposing flow case lower solution branch unstable upper solution branch stable addition shown regular fluid phi good agreement exists present numerical results reported open literature research limitations implications problem formulated three types nanoparticles namely copper alumina alo titania tio however paper present results nanoparticles analysis reveals boundary layer separates plate beyond turning point possible get solution based boundary layer approximations obtain solutions full basic partial differential equations solved practical implications nanofluids many practical applications example production nanostructured materials engineering complex fluids cleaning oil surfaces due excellent wetting spreading behavior etc social implications nanofluids could applied almost disease treatment techniques reengineering nanoparticle properties originality value present results original new boundary layer flow heat transfer past vertical flat plate embedded porous medium saturated nanofluid therefore study would important researchers working porous media order become familiar flow behavior properties nanofluids
relational web driven database accompanied strength modeling tool developed provide generic flexible information technology tool enable someone fast internet access strength useful properties wide range structural natural artificial damageable materials since many structural plain composite materials usually involved every geotechnical engineering subsurface surface geostructures bolted shotcreted rock slopes tunnels compensation grouting steel glass reinforced plastic tendons soils retaining walls wooden piles contact soils etc following five classes engineering structural materials considered porous pressure sensitive materials like rocks soils concretes ceramics well woods crystalline ductile materials metals alloys amorphous materials like glasses
natural killer cells play critical role tumor cells hematological malignancies activating receptors essential tumor cell killing multiple myeloma patients cell differentiation activation cytotoxic potential strongly impaired leading escape immune surveillance tissues bone marrow mechanisms used affect cell functions mediated release soluble factors expression activating inhibitory cell ligands expression immune check point inhibitors lenalidomide represents efficient clinical approach treatment improve patients survival lenalidomide promotes tumor apoptosis also stimulates cells thereby facilitating mediated tumor recognition killing occurs since lenalidomide acts several critical points stimulates cell proliferation cytokine secretion decreases expression immune check point inhibitor programmed death cells patients decreases expression cells promotes cell death abrogates stromal microenvironment cross talk process known promote cell survival proliferation leads inhibition negative signal induced pdl axis cells restoring cell cytotoxic functions given importance effective immune response counteract progression promising approaches using anti strategies discuss review lenalidomide could represent adequate approach establish recognition exhausted cell
background number people living hiv aids rise problems like renal dysfunction needs addressed study aimed providing data regarding prevalence association certain modifiable non modifiable factors renal function materials methods cross sectional study hiv positive subjects renal function assessed means egfr calculated using cockcroft gault equation proteinuria estimated spot urine albumin creatinine ratio uacr renal dysfunction identified either egfr data analysed based demographic characteristics type duration art height weight body mass index count blood pressure fasting lipid profile renal dysfunction group normal renal function group results study population renal dysfunction sixty percent females higher mean duration art months lower mean counts cells associated renal dysfunction mean height mean weight kgs lower renal dysfunction group significant mean ldl cholesterol serum triglycerides higher among renal dysfunction group different types art regimen bmi blood pressure hdl cholesterol total cholesterol found insignificant association study conclusion every one five hiv positive subjects might renal insufficiency common females lower height lower weight increased duration art therapy associated decreased renal function screened different types art regimen body mass index systolic diastolic blood pressure show effect renal function study decrease count shown positive correlation decrease estimated gfr subjects greater immunosuppression screened frequently high triglyceride levels high ldl levels associated decreased renal function
virtual reality used fields cognitive sciences study participants reactions cases existence avatars virtual environment crucial factor study investigate whether agents social influence participants performing asch conformity experiment immersive virtual environment findings demonstrating participants response times affected judgments agents existing virtual environment
introduction communication improves well quality life people dementia professional family caregivers individualized communication required informed consent procedures psychosocial interventions improve quality life especially ambulatory settings however valid reliable instruments exist enable communication assessed communication behavioral resources identified therefore extended adapted newly developed observational instrument codem use ambulatory settings codemamb methods results reliability validity new instrument studied total patients whereby principal component analysis revealed three important factors relationship aspects verbal communication behavior nonverbal communication behavior codem amb internal consistency interrater retest reliability satisfactory excellent convergent validity indices shown examining correlations similar identical constructs cerad verbal subscales medium high divergent validity index constructional praxis relatively low relationship peer rating remained nonsignificant criterion validity investigated groups patients accordance cognitive status expected verbal communication abilities deteriorate faster relationship aspects communication disease progresses conclusions summary codemamb reliable valid instrument used collect important information ultimate aim supporting communication people dementia
first imaging modality patients suspected distal radioulnar joint pathology conventional radiography exclude diagnose wrist pathology including osteoarthritis rheumatoid arthritis calcium pyrophosphate deposition disease healed fractures impaction syndromes conventional radiography inconclusive high resolution tesla magnetic resonance imaging advised provide broad overview literature regarding use intra articular contrast computed tomography cta magnetic resonance imaging mra conventional arthrography unenhanced computed tomography indicated article discusses useful imaging techniques terms clinical indications patient positioning technical imaging requirements diagnostic performance patients suspected distal radioulnar joint pathology furthermore prevalent pathologies discussed focus imaging characteristics stable unstable distal radioulnar joints
hematopoietic stem cell transplantation carries nutrition related risks therefore nutritional therapy needs initiated transplantation even takes place assessed nutritional risk among patients underwent allogeneic stem cell transplantation assessed nutrient supply calorie supply protein supply chart review assessments made pretreatment phase transplantation end parenteral nutrition patients underwent allogeneic stem cell transplantation shizuoka cancer center compared nutrition related adverse events parameters two groups loss body weight loss body weight correlation observed changes weight skeletal muscle mass group loss body weight group following variables loss body weight nutrient supply calories protein orally ingested nutrient supply calories protein start day oral intake acute graft versus host disease orally ingested calories negatively correlated nutrition related adverse events groups early customized nutritional intervention may optimal patients undergo allogeneic stem cell transplantation ameliorate body weight loss associated nutrition related adverse events
objective peripheral nerve stimulation pns used treatment neuropathic pain many decades despite specific indications pns clinicians often difficulty screening candidates likely good fair outcome given expense permanent implant insurance companies pay implant without successful pns trial since pns recently approved food drug administration many insurance companies pay conventional trial pns objective study describe short low cost method trialing screening patients peripheral nerve stimulator implantation additionally study demonstrates long term efficacy pns treatment chronic neuropathic pain relative effectiveness novel screening method methods records patients undergone trialing implantation pns system chronic refractory pain authors institution year period august july examined retrospective case series search revealed patients undergone novel office ultrasonography guided stimucath screening technique undergone traditional week long screening procedure patients experienced successful pns trial proceeded permanent pns system implantation patients followed mean duration years visual analog scale vas pain scores used assess pain relief short term pain relief average reduction vas score patients attaining fair relief relief still using stimulation therapy among remaining patients stimulator explanted relief excluding explanted cases follow ranged months average months patients good fair relief experienced pain prior implantation average years range years longer duration pain trended toward poorer outcome bad outcome years good outcome years seven patients shorter trial experienced good fair outcome average reduction vas score however bad outcome cases came group three patients longer trial experienced good fair outcome last follow average reduction vas score difference trialing methods proportion favorable good fair outcomes conclusions short ultrasonography guided stimucath trials feasible screening patients permanent implantation pns efficacy similar traditional week long screening noted year follow
abundant dinosaurian tracksites lower cretaceous valanginian barremian broome sandstone dampier peninsula western australia form important part west kimberley national heritage place previous attempts document tracksites using traditional mapping techniques surface overlays transects gridlines combined conventional photography hindered non trivial challenges associated working area including limited remoteness many tracksites occurrence majority tracksites intertidal zone size complexity many tracksites extending several square kilometres using historically significant well known dinosaurian tracksites minyirr gantheaume point show issues overcome use integrated array remote sensing tools combination high resolution aerial photography manned unmanned aircraft airborne handheld high resolution lidar imaging handheld photography enabled collection large amounts digital data models tracksites varying resolutions constructed acquired data encompasses broad scale sub millimetre level details individual tracks multiple kilometre level encompasses discontinuous tracksite exposures large swathes coastline former useful detailed ichnological work latter employed better understand stratigraphic temporal relationship tracksites broader geological palaeoecological context approaches data generate provide means digital conservation temporal monitoring dampier peninsula dinosaurian tracksites occur plans going management tracks area progress analysis data visualization also likely provide important means broader public experience spectacular national heritage listed landscapes
paper presents new active elements namely differential difference transconductance amplifier ddta differential difference current conveyor transconductance amplifier ddccta unlike previously reported papers active elements paper implemented using either commercially available integrated circuits ics techniques cmos bipolar technologies using elements based circuits achieved circuits implemented discrete forms workability proposed circuits confirmed pspice simulators
paper deals nonlinear inverse source problem identifying unknown time dependent point source occurring two dimensional evolution advection dispersion reaction equation spatially varying velocity field dispersion tensor originality study consists establishing constructive identifiability theorem leads develop identification method using significant boundary observations operating classic optimization approach end derive two dispersion current functions main property orthogonal gradients yield identifiability elements defining involved unknown source boundary observations related associated state provided velocity field fulfills called slipping condition required boundary observations reduced recording state outflow boundary flux inflow boundary monitored domain establish identification method uses boundary records localize sought source position unique solution nonlinear system defined two dispersion current functions give lower upper bounds total amount loaded unknown time dependent source intensity function transform identification latest solving deconvolution problem numerical experiments variant surface water bod pollution model presented
objective study formulate evaluate pulsatile drug delivery containing combination domperidone paracetamol treatment migraine used deliver drug specific time per pathophysiological need disease improvement therapeutic efficacy patient compliance domperidone paracetamol core tablet formulated different concentration superdisintegrants microcrystalline cellulose outer shell tablet formulated different weight ratios ethyl cellulose hydroxyl propyl methylcellulose hpmc effects formulation core tablet outer shell press coated tablets drug release lag time investigated formulation optimized based acceptable tablet properties vitro drug release release profile press coated tablet exhibited lag time dependent upon amount hpmc compression coating followed burst release optimized batch prt gave lag time drug release paracetamol domperidone respectively consisted equal amount hpmc based results programmable pulsatile release achieved formulation prt meet demand chrono therapeutic objective
paper presents identification technique characterize contractive pore pressure behavior loose sandy soils seismic excitation technique relies acceleration pore pressure records provided excitation vertical arrays accelerometers pore pressure sensors technique employs non parametric estimates shear stresses strains multi surface plasticity approach used model soil response reduced scale centrifuge model large scale experiment used demonstrate capabilities developed technique technique allows complete interpretation coupled shear volume behavior soil deposit elsevier ltd rights reserved
known approaches parallel data processing relational client server database management systems based inter query parallelism nevertheless possible achieve intra query parallelism consideration request structure implementation mathematical methods parallel calculations equivalent transformation article presents example complex query parallelization describes applicability graph theory methods parallel computing query parallelization optimization
electromagnetic harvesters need designed mechanism amplify coil relative velocity ensure compact size lower weight paper discusses novel technique use fluid link velocity amplification electromagnetic shock absorber incorporation fluid amplification significantly improves harvested power without affecting system dynamics numerical modelling experimentation prototype shock absorber comprising high energy rare earth magnets presented peak coil voltage recorded experimentation prototype experimental simulation results validate incorporation fluid amplification link improves harvested electric power comprehensive design procedure better harvesting efficiency vibration isolation discussed lastly incorporation shock absorber mcpherson strut suspension illustrated real size version able harvest peak power suspension velocities
present three new matrix spectral problems based real special orthogonal lie algebra construct corresponding asymmetric soliton hierarchies akns type type wki type aid symbolic computation maple hamiltonian structures yielding liouville integrability resulting soliton hierarchies furnished trace identity newly presented equations possess infinitely many commuting symmetries conservation laws
instructional strategies helpful facilitating students knowledge construction developing advanced cognitive skills context collaborative learning instructional strategies scripts guide learners engage meaningful interaction previous studies investigated benefits different instructional strategies nonetheless relatively little attention paid illustrating learners cognitive processing behavioral patterns learning process nowadays proliferation information technology behavior interaction learners conveniently documented analyzed aim study propose new approach examining learning process study designed four week collaborative learning activity involving four widely used instructional strategies problem solving peer assessment role playing peer tutoring blogs used support students collaboration total discussion messages retrieved data analysis quantitative content analysis lag sequential analysis employed explore content structure behavioral patterns demonstrated students online discussions results showed students exhibited relatively cognitive process understand peer assessment peer tutoring instructional strategies meanwhile students showed relatively cognitive process create problem solving role playing strategies implications findings suggestions subsequent work discussed
nanoscale resistive memory devices expected fuel dense integration electronic synapses large scale neuromorphic systems realize brain inspired computing chip compact cmos spiking neuron performs situ learning computing driving large number resistive synapses desired brief presents novel leaky integrate fire neuron design implements dual mode operation current integration synaptic drive single operational amplifier opamp enables situ learning crossbar resistive synapses proposed design implemented cmos technology measurements show neuron ability drive thousand resistive synapses demonstrate situ associative learning neuron circuit occupies small area energy efficiency value spike synapse
purpose details regarding risk factors onset outcomes denosumab related osteonecrosis dronj sparse study examines clinical characteristics operative non operative therapeutic outcomes patients dronj previously exposed antiresorptives methods retrospective medical record review conducted data collected including clinical findings management healing outcomes radiologic histologic micro computed tomography analyses results seventeen patients treated denosumab doses dronj onset majority lesions observed sites dental prostheses dental extractions sixteen patients managed non operatively operatively either major minor surgery included follow analysis complete healing significant patients treated major surgery compared non operative group denosumab discontinued non operative patients major surgery patients effect healing histologic findings patients analyzed exhibited decreased number osteocyte lacunae micro patients scanned revealed trabecular thickening conclusion dronj lesions occurred mostly sites prostheses sores mean doses denosumab major surgery demonstrated complete healing non operative management denosumab cessation improve healing outcomes european association cranio maxillo facial surgery published elsevier ltd rights reserved
paper introduce algorithmic process associate leibniz algebras combinatorial structures concretely designed algorithm automatize method obtain restrictions structure coefficients law leibniz algebra determine associated combinatorial structure algorithm implemented symbolic computation package maple moreover also present another algorithm implementation draw combinatorial structure associated given leibniz algebra structure pseudo digraph application algorithms studied pseudo digraphs associated low dimensional leibniz algebras determination restrictions edge weights structure coefficients corresponding combinatorial structures international association mathematics computers simulation imacs published elsevier rights reserved
paper tells story sports coach accused emotional abuse child athlete following investigation club cleared allegation accounts allegations rare research date explored coaches lived experiences stories dangerous remain largely unrecognised undebated represent challenge meta narrative child protection using stance storyteller coach participant story presented monologue crafted using words embellished literary techniques story purposefully largely left open interpretation attempt encourage readers engage cognitively emotionally telling dangerous story aims add narrative repertoires available working field expand understandings child protection sport
introduction although contraceptive options women expanded considerably last decade methods often offered women choices clinicians well informed limiting ability women control fertility areas covered areas covered include use oestradiol instead ethinyl oestradiol improved progestogens utilised hormonal contraceptives new delivery systems enabled development long acting methods require less action part user thereby reduce failure rates effective emergency contraceptive methods become readily available counter however male contraception despite much research still remains elusive expert opinion manuscript provide assessment recent advances controversies contraception make suggestions improved availability
purpose initiative determine effects penicillin skin testing pst antimicrobial stewardship perspective described summary penicillin allergy one frequently reported altergies however self reports penicillin allergy accurate incorrect penicillin allergies therefore significant barrier antimicrobial stewardship important clinical economic implications including increased antimicrobial resistance increased overall cost care increased length stay ultimately increased mortality part antimicrobial stewardship program community health system launched pst initiative order optimize therapy reduce adverse events acquisition costs minimize development antibiotic resistance pst prograit involves use standardized protocol assessment hypersensitivity penicillin patients suspected penicillin allergy among patients completed pst protocol eight month period negative result patients conversion antimicrobial therapy penicillin cephalosporin implemented direct result pst conclusion patients self reported penicillin allergy pst led reduction use carbapenems aztreonam vancomycin broad spectrum agents within health system decrease drug costs documented sample patients switched penicillin cephalosporin pst
chytrid fungus batrachochytrium dendrobatidis one important contributors decline amphibian populations worldwide evidence indicates harmfulness infection depends species life stage fungus strain season environmental factors present paper experimentally investigated susceptibility sensitivity five south american tadpole species rhinella fernandezae scinax squalirostris hypsiboas pulchellus leptodactylus latrans physalaemus fernandezae foreign strain jel response two populations fernandezae native strain mla iii virulence native foreign isolates tadpoles species also evaluated relationship infection loss keratinised mouthparts fernandezae found species except latrans susceptible infection lethal consequences fernandezae sensitive species fernandezae sensitivity infection depended population well strain although relationship found fungal infection loss keratinised mouthparts first experimental study mortality rates south american tadpoles exposed
hepatitis virus hcv hepatotrophic lymphotropic virus causes liver well extrahepatic manifestations including cryoglobulinemic vasculitis frequent studied condition lymphoma neurologic cardiovascular endocrine metabolic renal diseases hcv extrahepatic manifestations hcv ehms may severely affect overall prognosis viral eradication significantly reduces non liver related deaths different clinical manifestations may coexist patient due variety hcv clinical manifestations multidisciplinary approach alongwith appropriate therapeutic strategies required era interferon free anti hcv treatments international recommendations therapeutic management hcv ehms needed implies need define best criteria use antivirals therapeutic approaches present recommendations based qualified expert experience specific literature focus etiological antiviral therapies traditional pathogenetic treatments still maintain therapeutic utility authors published elsevier
present new numerical system using classical finite elements mesh adaptivity computing stationary solutions gross pitaevskii equation programs written toolbox freefem www freefem org free finite element software available existing operating systems offers advantage hide technical issues related implementation finite element method allowing easily code various numerical algorithms two robust optimized numerical methods implemented minimize gross pitaevskii energy steepest descent method based sobolev gradients minimization algorithm based state art optimization library ipopt methods mesh adaptivity strategies used reduce computational time increase local spatial accuracy vortices present different run cases made available configurations bose einstein condensates rotation optional graphical user interface also provided allowing easily run predefined cases user defined parameter files also provide several post processing tools like identification quantized vortices could help extracting physical features simulations toolbox extremely versatile easily adapted deal different physical models program summary program title gpfem catalogue identifier afbd program summary url http cpc qub summaries afbd html program obtainable cpc program library queen university belfast ireland licensing provisions apache lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language freefem free software www freefem org computer mac super computer operating system windows mac linux classification nature problem software computes stationary solutions gross pitaevskii equation rotation main application computation different types vortex states abrikosov vortex lattice giant vortex rotating bose einstein condensates software easily modified take account different related physical models solution method user choice two robust optimized numerical methods direct minimization gross pitaevskii energy steepest descent method based sobolev gradients minimization algorithm based state art optimization library ipopt methods mesh adaptivity strategies implemented reduce computational time increase local spatial accuracy vortices present running time minutes configurations hours cases personal laptop complex cases hundreds vortices may require several days computational time elsevier rights reserved
comparison conventional operational amplifier ring amplifier achieve better power efficiency switched capacitor circuits however cascade inverter architecture ring amplifier may suffer undesirable oscillation great impact transient stability paper presents latched based ring amplifier capable decreasing probability oscillation besides two auto zero schemes employed different pipelined stages reduce common mode voltage offset increase stability prototype adc fabricated cmos technology measured sndr sfdr respectively nyquist frequency input sampled adc consumes
quality context qoc awareness recognized key point success context aware computing time combination internet things cloud computing ambient intelligence paradigms offer together new opportunities managing richer context data next generation distributed context managers dcm facing new challenges concerning qoc management paper presents model driven qocim framework qocim acronym quality context information model show help application developers manage whole qoc life cycle providing genericity openness uniformity usages illustrated design time runtime case urban pollution context qoc aware scenario
sleep problems common chronic disorders like diabetes result poor diet unhealthy lifestyles comprehensive management diabetes entails lifestyle management restoration good habits sleep hygiene maintenance helps persons living diabetes enjoy better quality life restoring normal sleep patterns thereby improving glycaemic control
background systematic adaptation evidence informed interventions increase retention care improve adherence antiretroviraltherapy art essential ending hiv epidemic rural sub saharan africa selected adapted adherence support worker intervention employed malawi use traditional healers rural mozambique given levels trust dependence previously expressed persons living hiv plhiv traditional medicine adapted program engage traditional healers within allopathic health system methods adaption followed theoretically driven approach intervention adaption assessment decision administration production topical experts integration training testing adapt itt model three rounds performance feedback based theater presentations adapted intervention stakeholders idea generation completed groups march july develop final model offered healer support newly diagnosed hiv infected patients results traditional healers acceptable group community health workers assist patient adherence retention traditional healers clinicians interested community members suggested novel strategies tailor adherence support worker intervention revealing local culture hiv denialism aversion health system dislike healthcare providers well preference traditional treatments proposed changes intervention included modifications training language topics expanded community based activities support acceptability hiv diagnosis facilitate partner disclosure accompaniment health facility healers encourage delivery respectful clinical care plhiv healers clinicians deemed intervention socially acceptable focus groups subsequently recruited newly diagnosed hiv infected patients program accepted conclusions systematic translation interventions even regions similar social economic environments important first step successful program implementation efforts previously limited community health workers tailored use traditional healers underutilized often maligned health workforce proved feasible use theater based performances demonstrate delivery intervention low literacy populations generating discussions social norms community concerns merits acceptable strategy improve retention adherence art
long term therapy ifn alpha associated sustained major molecular remissions jak positive efficacy ifn alpha may partly mediated modulation immune cells investigated twenty patients frequency foxp cells significantly increased ifn alpha treatment patients significant expansion bright cells concomitant decrease frequency dim cells also detected myeloid dcs mdcs plasmacytoid dcs pdcs studied nine patients decreased frequencies cell types observed course treatment mdcs pdcs hla abc expression upregulated decreasing expression levels hla detected mdcs expression increased confined pdcs furthermore expression reduced mdc increased pdcs significant correlations found changes immune cells hematological molecular responses achieved cohort patients forth remains revealed whether profound changes circulating immune cells contribute beneficial effects long term ifn alpha treatment patients
background total knee arthroplasty tka frequently performed joint replacement surgery north america patient perspectives tka investigated various ways including finding many tka patients dissatisfied surgical outcomes understanding patient experience tka broadly relation patient satisfaction key gap existing literature methods report qualitative component mixed methods prospective cohort study examining patient experience satisfaction post tka adults british columbia canada data collection consisted depth interviews individuals knee surgery experiences conducted eight months surgery analysis consisted thematic coding multiple coders results participants descriptions tka experiences primarily concerned support provision aid assistance support insufficient expectations support met unmet support expectations led overall negative tka experience support operated three key domains informational support clinical support personal support key sources informational clinical support included pre optimisation clinics surgeons physiotherapists key topics informational support included pain pain management recovery trajectories personal support provided family friends tka patients employers conclusions patient needs expectations support shaped tka surgery patients overall positive tka experience improvement knee pain stiffness functioning post tka major expectations needs support met tka recovery believed significant future expectations needs ongoing support would adequately met contrast patients overall negative tka experience least one major expectation need support met tka recovery even cases good tka outcomes suggested interventions improve experience persons receiving tka include expanded patient navigator model revised pre surgery educational materials particularly around pain expectations management comprehensive sharing patients tka experience
ambulatory senior health clinic developed using chronic care model ccm emphasis interdisciplinary team approach determine effect care model approach nonprofit healthcare system observational longitudinal panel study community dwelling medicare beneficiaries performed examine effect physical function health related quality life hrql participants study recruited community sample eligible medicare beneficiaries informed consent baseline data obtained individuals recruitment response rate complete data across months completion response rate participants receiving care ccm based senior healthcare practice compared patients primary care physicians supported care managers group without care managers self reported data collected telephone measure physical function hrql baseline months multiple group mixture growth model used analyze physical function hrql across months physical function hrql mean scores decreased across time participants moderately correlated wave correlation coefficient two latent growth classes identified class physical function decreased hrql remained stable across time class physical function hrql decreased parallel ninety seven percent intervention group patients class patients comparison groups class despite physical function decline patients senior health clinic care model maintained hrql time whereas patients receiving traditional care physical function hrql decline interdisciplinary team ccm approach appears positive effect hrql population
aims isolated human umbilical vein robust contractile bioassay ligands bradykinin receptor also extendable receptor pharmacology hypothesized freshly isolated vessel also contains traces plasma proteins may confer responses exogenous proteases via formation kinins main methods rings human umbilical veins mounted organ baths containing krebs buffer maintained degrees purified proteases introduced bathing fluid along additional drugs proteins permit mechanistic analysis effects key findings previously described contractile response human recombinant tissue kallikrein klk influenced metabolic inhibitors suggesting dependence preexisting reservoir low molecular weight kininogen active plasma kallikrein apk inactive fresh tissues unless high molecular weight kininogen replenishment applied effects klk apk abolished pretreating tissues icatibant tranexamic acid esterase inhibitor inhibited apk purified plasmin neutrophil proteinase produced small contractions presence tissue plasminogen activator none stimulation pharmacologically evidenced response klk supplied significance pharmacology klk apk human isolated umbilical vein essentially based activity locally generated kinins assaymodels inhibitory action therapeutic agents active angioedema states proteases indirectly generate kinins little activity system elsevier inc rights reserved
room temperature duplex structure duplex stainless steel always metastable suggests non equilibrium phase transformation exploited producing duplex stainless steel chemical compositions phase constitution different microstructures work uses rapid solidification obtained duplex stainless steel expand heat treatment temperature range achieving duplex structure research shows equilibrium state phase constitution duplex stainless steel sufficiently long time annealing establishes non equilibrium kinetics diagram ferrite austenite transition cold rolled duplex stainless steel shown duplex stainless steel austenite phase prepared using different non equilibrium thermal process yield strength elongation vary ranges mpa respectively sample exhibits best combination yield strength mpa elongation attributed bimodal distribution austenite grain size
innovative behaviour animals ranging invertebrates humans increasingly recognized important topic investigation behavioural researchers however constitutes innovation remains controversial difficult quantify drawing broad definition whereby behaviour new component innovation propose quantitative measure call magnitude innovation describe extent innovative behaviour novel allows distinguish innovations slight change existing behaviours low magnitude innovations substantially different high magnitude using mathematical modelling evolutionary computer simulations explored aspects social interaction cognition natural selection affect frequency magnitude innovation show high magnitude innovations likely arise regularly even frequency innovation low long frequency relatively constant selectivity social learning existence social rewards prestige royalties crucial innovative behaviour evolve suggest consideration magnitude innovation may prove useful tool study evolution cognition culture
shore zones transition areas ecotones aquatic terrestrial ecosystems function environment crucial serve buffer zones capture pollutants slow erosion reservoir watercourse banks provided managed properly research shore zone conducted msciwojow retention reservoir innovative water self purification system several years operation increased phosphate concentration main part reservoir reported mapping terrain surface modeling hydrological processes direct catchment area said reservoir done using digital elevation model dem dem created lidar data obtained airborne laser scanning analyses surface runoff led identification surface runoff transport pathways along eroded material cultivated fields discharged directly reservoir surface runoff transport pathways gather eroded material maximum area western part direct catchment eastern part due reservoir management negligence riparian zone designed msciwojow reservoir longer exists percentage natural shore undergoes erosion processes said processes fluctuations water level reservoir well degradation shore zone caused human activity bring limited plant development littoral zone turn lowers reservoir resistance degradation
purpose perform validation brazilian version voice disability coping questionnaire vdcq using procedures according scientific advisory committee medical outcomes trust psychometric analyses determine scales validity reliability methods preliminary procedures vdcq administered patients determine items culturally valid propose possible adaptations vdcq sample study consisted data set individuals vocal complaint comprising men women mean age years without vocal complaint comprising men women mean age years demonstrate validity vdcq scores compared vocal self assessment perceptual analysis determine reliability test retest reproducibility voice patients repeated measurement days first administration results principal component analyses patients vocal complaint yielded four coping strategies venting support seeking minimisation avoidant acceptance subscales questionnaire showed acceptable internal consistency reproducibility values apart minimisation subscale vdcq validity demonstrated relationships perceptual analyses vocal self assessment subscale score differences two groups conclusions vdcq submitted essential steps necessary cultural adaptation validation simple instrument administer shows specific evaluating patients voice problems vdcq important addition voice evaluation patients dysphonia
dynamic pricing network revenue management received considerable attention research practice based data obtained major hotel use large scale numerical study compare performance several heuristic approaches proposed literature heuristic approaches consider include deterministic linear programming resolving three variants dynamic programming decomposition dynamic programming decomposition considered one strongest heuristics method chosen recent commercial implementations remains topic research recent academic literature addition plain vanilla implementation dynamic programming decomposition consider two variants proposed recent literature base scenario generated real data show method based zhang improved dynamic programming decomposition approach network revenue management manufacturing service oper management leads small significant lift revenue compared approaches generate many alternative problem scenarios varying capacity demand ratio network structure show performance different heuristics strongly influenced overall paper shows promise recent proposals academic literature also offers cautionary tale choice heuristic methods practical network pricing problems
schwann cells scs proliferation crucial nerve regeneration following nerve injury study aims investigate effects interleukin scs proliferation vitro well corresponding mechanism rat scs treated rat cell proliferation apoptosis detected using fluorescent staining flow cytometry transcriptome sequencing raw reads filtered mapped reference genome differentially expressed genes degs long non coding rnas delncrnas control groups identified tool cuffdiff functional pathway enrichment analyses performed tool gofunction protein protein interaction ppi network constructed tool string cytoscape furthermore pearson correlations degs delncrnas analyzed regulatory network degs delncrnas transcription factors tfs constructed significantly inhibited proliferation value promoted apoptosis schwann cells totally degs delncrnas identified among ccl ccna hub genes ppi network regulated degs enriched apoptosis related terms whereas regulated degs enriched proliferation related terms delncrnas like nonratt nonratg nonratt correlated multiple degs enriched cell cycle division moreover regulated tfs egr cebpd atf play crucial roles regulatory network nonratg cebpd ccl nonratt nonratt atf ccna nonratt egr aldoc eno serpine regulatory pathways identified scs treatment might influence scs proliferation apoptosis via regulating lncrna gene pathways scs however studies required confirm results
aimcentral efferent afferent neural pathways human urinary bladder well characterized location arborization nerves traverse serosa muscularis urothelial layers clearly defined purpose study create three dimensional map innervation human bladder trigone extrinsic perivesical adventitial nerve trunks urothelium methodsa male female human bladder harvested fresh frozen cadavers fixed formalin bladder neck trigone region serially sectioned every slide stained scanned aligned create maps resultsnerve penetration detrusor muscle occurs highest frequency bladder neck interureteric ridge nerves traveling parallel bladder lumen adventitia beyond outer border detrusor females depth nerve bands uniform luminal surface outer limits include anterior vaginal wall male depth variable owing detrusor hypertrophy minimum depth nerves approximately near interureteric ridge near bladder neck conclusionsmyelinated neural pathways traversing human bladder region trigone discreet regional density map trigonal innervation may provide guidance precisely direct therapies urinary incontinence pelvic pain neurourol urodynam wiley periodicals inc
genomic prediction relies genotypic marker information predict agronomic performance future hybrid breeds based trial records effect markers may vary substantially influence different environmental conditions marker environment interaction effects taken account however may lead dramatic increase computational resources needed analyzing large scale trial data high performance computing solution called needles presented handling data sets needles tailored particular properties underlying algebraic framework exploiting sparse matrix formalism suited utilizing distributed computing techniques enable use dedicated computing cluster demonstrated large scale analyses performed within reasonable time frames framework moreover analyzing simulated trial data shown effects markers high environmental interaction predicted accurately records per environment available training data availability data analysis needles also may lead discovery highly contributing qtl specific environmental conditions framework thus opens path plant breeders select crops based qtl resulting hybrid lines optimized agronomic performance specific environmental conditions
transitional age individuals social media integral component connecting others billion users worldwide users may experience increase perceived social support life satisfaction use may facilitate forming connections among people potentially stigmatizing mental disorders however epidemiologic studies suggest increased use associated conditions depression anxiety sleep disturbance future research examine directionality associations role contextual factors also useful leverage provide mental health care surveillance mental health concerns
water becoming even scarcer resource rainwater harvesting rwh systems becoming increasingly commonplace mechanisms capture store rainwater agricultural domestic use three important engineering considerations associated construction rwh systems capture surface area tank volume required specific demand levels number expected occupants purpose work evaluate engineering design rwh system semi arid texas region using non parametric stochastic rainfall generator based years data provide engineering charts equations future use model rwh system using simulation techniques order estimate requirements building system capable providing family water requirements demand never exceeding available supply demand satisfaction
study evaluated whether metformin might reduce esophageal cancer risk patients type diabetes mellitus diagnosed recruited reimbursement database taiwan national health insurance newly treated metformin ever users metformin antidiabetic drugs never users metformin followed december sensitivity analyses conducted matched pair sample never users ever users hazard ratios estimated cox regression incorporated inverse probability treatment weighting using propensity score risk associated infection helicobacter pylori epstein barr virus hepatitis virus hepatitis virus also evaluated results showed incidence esophageal cancer ever never users per person years respectively overall hazard ratio confidence intervals suggested significantly lower risk among metformin users hazard ratios comparing first months tertile cumulative duration metformin use never users respectively infection helicobacter pylori viral infections significantly increased risk could ameliorated metformin analyses matched sample consistently supported protective role metformin conclusion metformin reduces esophageal cancer risk cumulative duration approximately years
study investigated media exposure affects noncollege women envision futures days prolonged exposure experiment presented childless women aged magazine portrayals females gender congruent mother homemaker beauty ideals gender incongruent professional social roles responses open ended question revealed days media exposure gender congruent roles remained salient exposure homemaker portrayals induced thoughts possible future selves pfss fostered concerns motherhood career roles also produced positive affective valence compared exposure portrayals professional women particularly among women gender congruent life circumstances exposure impacts mediated extent women linked magazine portrayals pfss
cerebellar impairment frequent predictive disability multiple sclerosis nine hole peg test nhpt commonly used assess cerebellar symptoms despite lack specificity cerebellar ataxia eye tracking reliable test identifying subtle cerebellar symptoms could used clinical trials including involving early patients evaluate use eye tracking accuracy nhpt detecting subtle cerebellar symptoms patients clinically isolated syndrome high risk conversion cis twenty nine patients matched healthy controls underwent eye tracking protocol cerebellar impairment defined registration saccadic intrusions least dysmetria saccadic movement recording criteria compared nhpt performance sixteen patients fulfilled saccadic criteria cerebellar impairment nhpt performance significantly increased cis patients versus however nhpt performance differ cerebellar non cerebellar groups nhpt performance dominant hand could differentiate patients particularly cerebellar patients could discriminate cerebellar non cerebellar patients classified according saccadic criteria findings considered future clinical trials involving cis patients
synopsis objectivesto exploit microbial ecology bacterial metabolite production specifically evaluate potential use pigments prodigiosin violacein additives commercial sunscreens protection human skin determine antioxidant antimicrobial activities pathogenic bacteria two pigments methodsprodigiosin violacein used supplement extracts aloe vera leaf cucumis sativus cucumber fruit known photoprotective activity well commercial sunscreen preparations sunscreen protection factors spfs determined spectrophotometrically assays antimicrobial activity carried using well plates quantify growth inhibition staphylococcus aureus escherichia coli resultsfor plant extracts spfs increased order magnitude similar commercial sunscreens increased violacein prodigiosin antioxidant activities prodigiosin violacein approximately ascorbic acid well characterized potent antioxidant violacein inhibited aureus coli whereas prodigiosin effective bacteria values respectively conclusionthe bacterial pigments prodigiosin violacein exhibited antioxidant antimicrobial activities able increase spf commercial sunscreens well extracts two plant species tested pigments potential ingredients new product range indeed represent new paradigm sunscreens utilize substances biological origin discussed biotechnological potential bacterial metabolites use commercial sunscreens need studies mammalian cells determine safety
electrification vehicles drive affected motion dynamics longitudinal transversal directions primarily driving wheels slip acceleration drive wheel slippage due maximum value electric motor driving torque wheels acceleration another problem low frequency vibration mechanical parts propulsion system step changes electric motor torque paper presents algorithm electric drive system interacting motion dynamics electric car
background misuse codeine containing medicines emerging public health issue aims present application liese franz cognitive developmental model substance abuse trajectory legitimate codeine use pain towards therapeutic forms misuse physical psychological dependence illustrates cognitive behavioural analysis experiences codeine misusers surfaces specific beliefs thoughts emotions behaviours group hidden codeine dependent individuals distinct unique opioid dependent cohorts method depth one one interviews codeine misusers dependent individuals ireland south africa analysed applied liese franz cognitive developmental model substance abuse results misuse dependence pathways maintained interplay physiological determinants relating pain withdrawal tolerance psychological influences therapeutic need pre empting anticipated physical pain pleasure dreamy sedative opiate effect codeine relief emotional distress progression towards habitual use misuse therapeutic intoxication purposes appears mediated external environmental triggers pertaining availability internal meta cognitions around physical pain emotional distress increasing importance codeine life user conclusion concept mapping codeine misuse dependence presented could provide psychological therapists working individuals experiencing problems codeine misusing codeine iatrogenic dependence enhanced understanding key concepts involved misuse recovery pathways
trend multimegawatt wind turbines positioning multilevel converters promising solution high power wind energy conversion systems wecss furthermore due high penetration wind energy electrical network rather strict grid regulations development case fault grid power mainly grid codes set low voltage ride lvrt requirements grid connected wecs scenario paper presents novel modelation control strategy fulfil low voltage ride requirements using modular multilevel matrix converter interfacing high power wind turbine
objective identify relationships insulin resistance mitochondrial respiration perinatally hiv infected youth design case control study methods mitochondrial respiration assessed perinatally hiv infected youth tanner stages youth without enrolled pediatric hiv aids cohort study defined homeostatic model assessment value least novel high throughput oximetry method used evaluate cellular respiration peripheral blood mononuclear cells unadjusted adjusted differences mitochondrial respiration markers evaluated correlations mitochondrial respiration markers biochemical measurements results youth similar age sex race ethnicity mean age years respectively group significantly higher mean bmi metabolic analytes fasting glucose insulin cholesterol triglycerides venous lactate pyruvate compared mitochondrial respiration markers average lower compared including basal respiration pmol atp production pmol proton leak pmol maximal respiration pmol spare respiration capacity pmol nonmitochondrial respiration differ status results change adjusted age conclusion hiv infected youth lower mitochondrial respiration markers compared youth without disordered mitochondrial respiration may potential mechanism population
impedimetric aptasensor used study effect charge transfer binding prostate specific antigen psa aptamer full understanding mechanism beneficial improve sensitivity psa detection human semen physiologically relevant concentrations bare gold electrodes spaues gold nanoparticles aunps coated screen printed carbon ink electrodes aunps spces coated aptamer solution various concentrations sensor response increasing psa concentration buffer solution examined aunps deposited onto carbon electrodes cycles aunps spces coated self assembled monolayer sam mercaptohexadecanoic acid prior aptamer immobilization dose results indicate anisotropic aunps spces outperform bare gold electrodes terms decreased amount aptamer bunches well number intermediate psa aptamer complexes formed electrode surface key finding fabricated aptasensor sensitive enough limit detection lod early diagnosis prostate cancer displays linear response physiologically relevant concentration range shown calibration curve relative change electron transfer resistance delta versus psa concentration aptamer sam aunps spces exposed buffer containing psa different concentrations
green entrepreneurs seen key drivers transition green economy however limited depth qualitative empirical research green entrepreneurs date focusing instead typologies categorising certain types green entrepreneur moreover literature rarely situates individual activities within broader concepts green economy contrast suggest current discourses green economy important contextualising ways green entrepreneurs make sense businesses green entrepreneurs thus negotiating varying tensions business activities environmental philosophies wider contexts intersection green economy mainstream economy drawing evidence interviews explore narratives employed green entrepreneurs situate within outwith wider green economy recursive framing mainstream niche green activities provides sense tensions politics play development green economy thus offer new dynamic view evolving nature becoming green entrepreneur rather relying fixed categories espoused previous typologies conclude important policy makers recognise complex contentious nature green entrepreneurship essential view green economy diverse constellation myriad actors rather corporate reinventions business usual
background information processing speed ips prevalent cognitive impairment multiple sclerosis objectives review aims summarize methods applied assess ips theoretical conceptualization pubmed search performed select articles published january december resulting articles included results majority studies assessed ips heterogeneous samples several disease courses studies often report controlling presence neurological disorders age education alcohol history use steroids potential confounding variables recent relapses history developmental disorders visual problems often neglected assessments used study ips heterogeneous ranging simple complex tasks among studies review different tasks used articles defined construct ips discussed ips relation theoretical model future directions challenges upcoming decade include clarification definition ips well theoretical conceptualization consensus assessment based results obtained propose new theoretical model tri factor model ips
neonatal cutaneous mucormycosis ncm rare opportunistic angioinvasive fungal infection high mortality discuss presentation diagnosis management case ncm neonate survived weeks rigorous treatment need local surgical debridement necrotic skin patch systemic antifungals case highlights early diagnosis aggressive treatment essential manage otherwise highly morbid disease
objective evaluate whether climacteric symptoms related pelvic organ prolapse pop postmenopausal women study design cross sectional investigation performed postmenopausal women attending outpatient service menopause university hospital main outcome measures data regarding climacteric symptoms captured greene climacteric scale objective pop retrieved electronic database additional data retrieved age anthropometric measures personal reproductive history use medication drugs coffee smoking state anxiety stai scale score depression zung scale score results score greene climacteric scale higher women without pop multiple logistic regression models score independently related pop whole bladder prolapse uterus prolapse rectum prolapse rectocele conclusions postmenopausal women higher burden climacteric symptoms associated pop underlying mechanisms assessed deserve investigation elsevier rights reserved
structural organization peripheral nerves enables function tolerating adapting stresses placed upon postures movements trunk head limbs exposed combinations tensile shear compressive stresses result nerve excursion strain transverse contraction purpose appraisal review structural biomechanical modifications seen peripheral nerves exposed various levels physical stress followed primary tenet physical stress theory presented mueller maluf specifically level physical stress placed upon biological tissue determines adaptive response tissue thorough understanding biomechanical properties normal injured nerves stresses placed upon daily activities help guide physical therapists making diagnoses decisions regarding interventions
aims snm proven effective treatment refractory uui total costs patient burden due regular battery changes may prevent broad implementation treatment aim achieve minimal improvement incontinence episodes compared pre snm using isnm methods prospective cohort study performed women uui receiving treatment snm minimum months neurostimulator programmed per day weeks prior isnm data collected snm csnm bladder diaries various patient reported outcome measures collected predetermined time points weeks weeks nonparametric tests used statistical analysis results patients showed improvement incontinence episodes isnm compared pre snm bladder diary parameters showed difference pre snm isnm median value incontinence episodes incontinence severity voiding episodes voided volume udi iiq scores also showed significant improvement difference demonstrated isnm csnm conclusions compared pre snm parameters isnm shows improvement objective subjective outcomes specifically difference found isnm csnm indicating isnm could feasible cost effective alternative wiley periodicals inc
organization mammalian genome gene subsets corresponding specific functional classes provided key tools systems biology research created web accessible resource called mammalian metabolic enzyme database https hpcwebapps cit nih gov esbl database metabolicenzymes metabolicenzymedatabase html keyed biochemical reactions represented iconic metabolic pathway wall charts created previous century overall mapped genes pathways representing similar percent protein coding genome illustrate use database apply area kidney physiology created additional database database metabolic enzymes kidney tubule segments https hpcwebapps cit nih gov esbl database metabolicenzymes mapping mrna abundance measurements mined rna seq studies metabolic enzymes renal tubule segments carry bioinformatics analysis enzyme expression pattern among renal tubule segments mine various data sources identify vasopressin regulated metabolic enzymes renal collecting duct
large scale severe natural disturbance events drive spatial temporal patterns forests altering forest structure composition functions bavarian forest national park germany windthrow events led large disturbances caused european bark beetle ips typographus recently assumed initial stage regeneration trees tend form homogeneous stand structure whereas structural heterogeneity attribute later developmental stages yet recent studies provide evidence certain conditions structural heterogeneity arise much earlier stand development combined lidar data forest growth modeling based individual trees develop workflow studying forest development post disturbed areas upper montane regions national park current forest structure derived lidar data individually detected trees set forest structural attributes derived results served input simulate tree development spatio temporally period years several spatial statistics including landscape spatial point pattern metrics calculated assess structural heterogeneity results showed naturally regenerating forests post disturbed sites reveal structural heterogeneity already early seral stage moreover significant portion eventual old growth structural heterogeneity might already determined early successional stages workflow highlights use multi sensor aerial remote sensing provide detailed structural information useful investigation early phase forest dynamics elsevier rights reserved
itch thought represent peculiar response stimuli conveyed somatosensory pathways shared pain activation specific neurons receptors occur association dermatological systemic neurological diseases side effect certain drugs however patients suffer chronic idiopathic itch frequently ascribed psychological distress biomarker available date investigated three multigenerational families one diagnosed joint hypermobility syndrome ehlers danlos syndrome hypermobility type jhs eds characterized idiopathic chronic itch predominantly proximal distribution skin biopsy performed eight affected members revealed six reduced intraepidermal nerve fibre density consistent small fibre neuropathy whole exome sequencing identified two cola rare variants segregating chronic itch eight affected members absent non affected members one unrelated sporadic patient type painless diabetic neuropathy chronic itch two families diabetic patient carried nonsense glu variant another family carried missense argser variant variants predicted likely pathogenic silico analyses two variants rare minor allele frequency healthy controls absent small fibre neuropathy jhs eds patients without itch null allele test cdna patients fibroblasts families carrying nonsense variant demonstrated functional haploinsufficiency due activation nonsense mediated rna decay immunofluorescence microscopy western blotting revealed marked disorganization reduced cola synthesis respectively indirect immunofluorescence showed reduced cola expression skin patients carrying nonsense variant treatment gabapentinoids provided satisfactory itch relief patients carrying mutations findings first revealed association cola gene familiar chronic itch suggesting new contributor pathogenesis neuropathic itch identifying new candidate therapeutic target
rising rate overweight obesity public health crisis united states increasingly around globe rates contraceptive use similar among women weights contraceptive development studies historically excluded women ideal body weight patients providers gap understanding contraceptive efficacy obese overweight women range drug metabolism alterations obesity biologic plausibility changes hormonal contraception effectiveness obese women however pharmacokinetic changes linearly related body mass index weight unknown degree obesity begins affect pharmacokinetic pharmacodynamics processes overall studies higher quality demonstrate difference oral contraceptive pill effectiveness obese compared non obese women however data scant women highest categories obesity differences progestin type incompletely understood effectiveness non oral contraceptives seem compromised obesity exceptions include combined hormonal patch oral levonorgestrel emergency contraception may lower rates effectiveness obese women purpose review summarize evidence contraceptive use women obesity including differences steroid hormone metabolism contraceptive effectiveness safety compared women normal weight body mass index using methods american society reproductive medicine
gui testing essential provide validity quality system response applying development straightforward time consuming requires specialized personnel involves complex activities sometimes implemented manually gui testing tools help supporting processes however integrating software projects may troublesome mainly due diversity gui platforms operating systems use work presents design implementation open hmi tester oht application framework automation testing processes based gui introspection cross platform provides adaptable design aimed supporting major event based gui platforms also integrated ongoing legacy developments using dynamic library preloading oht provides robust extensible basis implement gui testing tools capture replay approach implemented proof concept introspection used capture essential gui interaction data used also simulate real human interaction order increase robustness tolerance changes testing iterations oht actively developed open source community shown paper ready used current software projects
purpose aprepitant parenteral formulation fosaprepitant widely used prevention chemotherapy induced nausea vomiting aprepitant exerts modest inhibitory effect cypa modest inductive effect cypc substrates antineoplastics multiple medications article aimed provide pharmacists healthcare professionals updated summary drug drug interactions aprepitant fosaprepitant implications clinical practice method reviewed publications reporting drug drug interactions aprepitant fosaprepitant medications results coadministration aprepitant antineoplastics opiods may result significant elevations serum levels agents metabolized via cypa best documentation cyclophosphamide ifosfamide erlotinib oxycodone alterations translate adverse outcomes necessitate dosing adjustments levels warfarin significantly decreased aprepitant requiring prolonged monitoring discontinuation aprepitant among direct oral anticoagulants theoretical interaction aprepitant rivaroxaban apixaban exists interactions aprepitant quetiapine diltiazem sirolimus required dose reductions avoid adverse outcomes intravenous route weaker inhibitory effect cypa oral pathway conclusion evidence drug interactions aprepitant medications limited impact therapeutic outcomes remains determined intravenous regimen may preferred option utilization aprepitant expanding practitioners patients need educated potential drug interactions need careful monitoring patients concurrently receiving aprepitant cypc cypa substrates especially narrow therapeutic window
recent years significant technological advances changed understanding dynamic processes clinical psychology particularly important agent change ambulatory assessment assessment individuals daily lives combining twin benefits increased ecological validity minimized retrospective biases benefits make particularly well suited assessment dynamic processes recent advancements technology providing exciting new opportunities understand processes new ways current article briefly detail capabilities currently offered smartphones mobile physiological devices well practical ethical challenges incorporating new technologies research provide several examples recent innovative applications methodology clinical research assessment intervention provide case example data generated study utilizing multiple mobile devices way aim provide sense direction researchers planning studies
maternal immune activation mia pregnancy rodents increases risk offspring develop schizophrenia related behaviors suggesting relationship immune system brain development tested hypothesis mia induced viral mimetic polyinosinic polycytidylic acid poly early late gestation mice leads behavioral neuroanatomical disorders adulthood gestational days gds pregnant dams treated poly saline via intravenous route offspring behaviors measured adulthood considering progressive structural neuroanatomical alterations brain individuals schizophrenia used magnetic resonance imaging mri perform brain morphometric analysis offspring aged one year mia led increased basal locomotor activity enhanced motor responses ketamine psychotomimetic drug reduced time spent center arena suggesting increased anxiety like behavior addition mia reduced glucose preference offspring none treatments altered relative volume lateral ventricles however decrease brain volume especially posterior structures observed one year old animals treated poly compared control groups thus activation maternal immune system different gds lead neuroanatomical behavioral alterations possibly related positive negative symptoms schizophrenia results provide insights neuroimmunonological neurodevelopmental aspects certain psychopathologies schizophrenia isdn published elsevier ltd rights reserved
computer graphics related fields bidirectional texture function btf used realistic predictive rendering btf allows capture fine appearance effects self shadowing inter reflection subsurface scattering needed true realism used rendering algorithms goal current research get surface representation indistinguishable real world developed produced tested portable instrument btf acquisition based kaleidoscopic imaging discuss colour issues experienced initial tests show colour balance applied whole picture spectral response instrument varies position image optical elements inspected contributions spectral behaviour instrument shelf parts either measured manufacturer data considered custom made mirrors spectral reflectivity simulated mathematical model instrument made found way implement contributions image processing pipeline way correct white balance individual pixel image found applied allowing faithful colour representation also proposed optimized dielectric protective layer kaleidoscope mirrors
article explores pre school reform shifting norms parenthood singapore whereas current education reforms many western countries focus improving academic performance pre school reform singapore emphasises academic learning urges parents adopt relaxed parenting practices analysing position parents process show however outcomes reform project highly ambivalent reform makers view parents mindset main obstacle reform parents experience pre school reform prompting inconsistent messages account disorientation creates among parents draw bateson concept double bind john wiley sons ltd national children bureau
substitution box box one significant structures used create encryption strong resistant attacks block encryption algorithms box plays important role data encryption paper presents novel box generation algorithm design based scaled zhongtang chaotic system study new random number generator uses new scaled zhongtang chaotic system complicated interesting dynamic features designed also new effective strong box design algorithm utilizing rng random number generator developed bits generated rng put nist tests passed nist tests non linearity bit independence criteria strict avalanche criteria differential approximation probability performance tests run proposed box produced new box design algorithm proposed box compared studies available literature proved stronger effective
pitched roof buildings make considerable proportion architectural roof styles precise estimation solar energy potential pitched roofs thus crucial sustainable development renewable energy consumption human habitats conventional solar radiation measurements usually adopt light detection ranging lidar data extracted existing buildings relatively little research assessing solar radiation pitched roofs paper develops pixel based approach estimation solar energy potentials pitched roofs based pretext architectural design drawings typical australian house nine roofs chosen implementation case study solar radiation certain cell shadow map mathematically formulated pixel unit yields certain time period calculated considering multiple instantaneous solar irradiances visually presented image processing resulting solar radiation maps especially coloured map reveal roofs radiation distribution including effects objects roofs chimneys radiation contour lines mapped obtain installation ranges solar devices study benefit commercial energy investors residents urban planners efficient use renewable energy sources accurate prediction solar radiation potential identification areas receiving high radiation sloping roofs elsevier rights reserved
contrastive part part presents generalised optimal linear quadratic digital tracker lqdt universal applications discrete time systems includes generalised optimal lqdt design system pre specified trajectories output control input additionally input output direct feed term known estimated system disturbances extra input output signals new optimal filter shaped proportional plus integral state feedback lqdt design non square non minimum phase systems achieve minimum phase like tracking performance new approach computing control zeros given non square systems one learning epoch input constrained iterative learning lqdt design repetitive systems
objective psychiatric symptoms varying degrees accompany hyperemesis gravidarum may continue throughout pregnancy psychological problems may cause morbidity study aimed evaluate relationship psychiatric symptoms first trimester postpartum depression methods two hundred seven pregnant diagnosed healthy pregnant women included prospective study cases assessed scl first trimester postpartum period factors related postpartum psychiatric symptoms investigated bivariate logistic regression analysis results scl scores statistically significant group cases diagnosed postpartum depression rates scl results higher bivariate analysis high rates high scl scores determined related postpartum depression conclusions results show mental health negatively affected pregnancy case psychiatric symptoms may continue even discontinuation
state leaders often promote implementation evidence based practices difficulty sustaining expanding time paper examines activities leaders states successfully implemented sustained expanded evidence based supported employment known individual placement support ips years interviewed state leaders states participating learning community regarding composition leadership team participation learning community interagency collaboration state policy alignment financing training monitoring fidelity outcome assess state level performance implementing sustaining expanding ips services obtained measures sustainment expansion program fidelity employment subsequent year compared priori benchmarks majority states met benchmarks sustainment expansion fidelity employment states varied widely specific actions advance ips established leadership teams participated national learning community built infrastructure supporting ips leaders states participating learning community adopted maintained multiple strategies sustain expand evidence based supported employment high level fidelity good employment outcomes
backgroundpractices facilitate self determination received appropriate attention research concerning parents intellectual disabilities likewise parenting interventions adults intellectual disabilities seldom observed parent child behavioural outcomes methodsthis study evaluated effectiveness parenting intervention embedded self determination facilitation practices two dyads parent intellectual disabilities young child interventions focused increasing parents ability correctly implement steps parenting routine reducing occurrence challenging child behaviour resultsthe results study demonstrated two basic effects correctly completed steps parenting routine reduction challenging child behaviour parents also reported decreased feelings stress routine following completion intervention conclusionsimplications future research replication pilot study discussed
paper presents overview student functions programming education support tool pgtracer utilizing fill blank questions pgtracer runs moodle provides fill blank questions composed program trace table students tool provide questions various difficulty levels program realized changing position blanks program trace table student fills blanks tool automatically evaluates answer tool automatically collects answers time evaluation result student log teacher analyze understanding level students analyzing log
synthetic pyrethroids present numerous commercial insecticide formulations extensive indoor outdoor applications worldwide including agricultural public residential veterinary usages pest control pyrethroid use increased continuously recent years aim review provide updated comprehensive information human exposure potential hazards associated class pesticides initial keyword search pubmed database conducted identify relevant articles taken considerations studies published last decade assessed exposure health effects pyrethroids human populations literature review shows exposure evaluations increasingly focus biomonitoring large number recent epidemiological studies pertain effects pyrethroids male fertility prenatal development main metabolites pyrethroids frequently detected urine samples general population confirming widespread exposure children adults one pyrethroids nonoccupational exposure pyrethroids mainly occurs ingestion residues food ingestion dermal contact contaminated house dust surface adhering particles following domestic use although clinical features resulting acute accidental exposure pyrethroids well described paraesthesiae respiratory eye skin irritation information regarding chronic effects low concentrations limited controversial several recent epidemiological studies raised concerns potentially adverse effects sperm quality sperm dna reproductive hormones pregnancy outcomes early neurobehavioural development utero exposure discussed research needed clarify possible risks associated long term environmental exposure pyrethroids elsevier gmbh rights reserved
maternal weight pregnancy associated offspring neurobehaviour childhood investigated maternal weight prior pregnancy relation neonatal neurobehaviour hypothesized maternal obesity excessive gestational weight gain would associated poor neonatal attention affective functioning participants recruited weighed interviewed third trimester pregnancy pre pregnancy weight self reported validated participants robust agreement medical chart review neurobehaviour measured nicu network neurobehavioural scale nnns administered days postpartum maternal exclusion criteria included severe persistent physical mental health conditions chronic disease diagnoses bipolar disorder psychotic spectrum disorders excessive substance use social service foster care involvement difficulty understanding english infants singleton full term weeks gestation births major medical concerns outcome variables summary scores nnns women obese prior pregnancy gaining excess institute medicine guidelines infants poorer regulation lower arousal higher lethargy main effects maternal pre pregnancy body mass index neurobehaviour women gaining institute medicine recommendations neonates better quality movement additional studies replicate extend results past neonatal period needed results could support underlying mechanisms explaining associations maternal perinatal weight offspring outcomes mechanisms may inform future prevention intervention strategies blackwell publishing ltd
dna possesses characteristics excellent biocompatibility biodegradation molecular recognition ability nanoscale controllability programmability recent decades dna taken assortment diverse roles central genetic molecule biological systems also generic materials nanoscale engineering dna hydrogel combines characteristics dna hydrogel controllable shape high mechanical strength materials delivery hydrogel formation includes chemical method based formation via covalent bond physical method based formation via non covalent bond dna hydrogel combine perssad molecule dna sequence sensitive incitant stimulating factor order expand application dna hydrogel dna hydrogel sensitive stimuli response light temperature small molecules novel dna hydrogels provide natural bridge nanotechnology biotechnology also leads dna hydrogel far ranging real world applications dna hydrogel smart material widely used biosensor drug delivery three dimensional cell culture review summarize classification dna hydrogel give stimuli response dna hydrogel biological application also development prospect dna hydrogel demonstrated
connection rapid increase volume semistructured unstructured data question optimal saving quite important optimal storage important saving convenient format processing resolve issue done review analysis non relational databases applications real example system preservation processing information medicines
integrated starter generator replaces conventional starter alternator one electrical machine handling functions start stop functionality vehicle launch assistance higher speed transient power supplementing enhance vehicle performance lower fuel consumption rate functionality requires electrical machine provide high starting launch assistant torque motoring mode relatively high power capability wide speed range battery charging overall cost system underlining concern crucial part design optimization paper focuses advantages induction machines ims automotive industry approach design cost effective electrical machine belted starter alternator applications design optimization described achieve desired performance including rotor bar count solid conductor bar winding versus stranded winding design rotor bar shape optimization finally performance maps electrical machine including predicted measured results thermal study machine also presented well noise vibration harshness nvh consideration design selection
many studies explored negative outcomes childhood maltreatment including psychopathology risk taking behaviors death suicide male may exacerbate negative symptoms following maltreatment result decreased sense psychological well much remains unexamined exploring factors may buffer negative outcomes maltreatment self compassion suggested aid improvement psychological well recovery traumatic events study examined relationship self compassion psychological well among sample men experienced childhood maltreatment testing model mediation findings reflected self compassion full mediator maltreatment psychological well served partial mediator implications future directions explored
paper presents novel algorithm architecture design band quasi class ansi octave filterbank proposed design several advantages lower group delay lower computational complexity lower matching error technique developed paper summarized follows simple low pass filter lpf discrete cosine transform dct modulation utilized generate uniform band filterbank first elements replaced pass filters obtain non uniform filterbank fast recursive structure variable length algorithm developed efficiently accomplish dct modulation thus spectrum lpf easily spanned flexibly extended location desired central frequency employing multi rate algorithm band non uniform filterbank generated two band sub filterbanks following proposed design steps parameter determinations compared latest liu quasi class ansi design proposed method proposed totally reduction multiplications per sample group delay additions decreased per sample moreover maximum matching error proposed method proposed averagely equal much smaller latest wei design proposed variable length dct modulation adders multipliers multiplexers registers required hardware implementation applying vlsi retiming scheme overall proposed filterbank design would new solution future applications area hearing aids
three decades since emergence environmental justice movement environmental injustices continue unfold across world include new narratives air water pollution well new forms injustices associated climate change energy use natural disasters urban greenspaces public policies adversely affect socially disadvantaged communities future generations focus issue environmental research letters provides interdisciplinary forum conceptual methodological empirical scholarship activism research policy highlights continuing salience perspective understanding nature society linkages letters published focus issue address variety environmental issues social injustices multiple countries across world advance research demonstrating environmental injustice emerges particular policies political processes exploring environmental injustices associated industrialization industrial pollution documenting unjust exposure various environmental hazards specific urban landscapes discourse continues evolve topically geographically hope focus issue help establish research agendas next generation scholarship distributive procedural participatory forms injustices well interrelationships
alzheimer disease common cause neurodegeneration dementia elderly dysregulated chronic activation microglia brain resident macrophages induces release excessive amounts pro inflammatory cytokines implicated early stages pathology therefore suppressing expression inflammatory mediators may decrease delay progression many natural compounds derived plants shown anti inflammatory activity naturally occurring penta galloyl beta glucose pgg polyphenolic compound highly enriched rhus chinensis millplant potent anti inflammatory agent act inhibition many cytokines different experimental models present study investigated role pgg anti inflammatory agent lps ifny activated microglia cells mouse cytokine antibody arrays used assess effect pgg release pro inflammatory cytokines elisa experiments performed validate results arrays results obtained cytoldne arrays elisa assays showed pgg decreased expression monocyte chemotactic protein mcp fold pro matrix metalloproteinase pro mmp fold cytokines upregulated inflammatory process shown involved brain injury inflammation neurodegeneration therefore findings suggest anti inflammatory effect pgg activated microglia involving attenuation mcp pro mmp cytokines elsevier rights reserved
evolution vibration relaxation hydrogen atoms metals close packed lattice high medium temperatures investigated based non equilibrium statistical thermodynamics number using retarded two time green function method accordance main kinetic equation generalized fokker plank kolmogorov equation anharmonism hydrogen atoms vibration potential wells make contribution collision effects influences relaxation processes expense interference fourth order anharmonism single phonon scattering impurity hydrogen atoms therefore total relaxation time vibration energy system metal hydrogen written product two factors relaxation time system harmonic approximation dimensionless anharmonic attenuation quantum hydrogen state
paper proposes novel variable speed control strategy particular phase permanent magnet synchronous generator pmsg healthy faulty modes taking account constraints voltages currents constraints related converter machine design considered faults open circuited phases one phase two adjacent phases two non adjacent phases variable speed control strategy presented including flux weakening operations based analytical formulations numerical computation proposed bring torque speed characteristics method allows determination current references ensure functioning phase pmsg variable speed keeping phase voltages currents limits theoretical numerical experimental results presented results compared order validate proposed approach elsevier rights reserved
background growing global acknowledgement improving child survival rates longer sufficient emphasis shifting improvement health developmental trajectories early childhood screening measurement trajectories low middle income countries difficult however currently rely developmental tests standardised among populations children growing resource rich environments methods paper presents comparison one tool adapted use children living southern africa children united states norway korea spain ages stages questionnaire version asq adapted administered children living south africa zambia results children southern africa found perform significantly better children countries early life especially domains communication gross motor fine motor skills age five children southern africa performing significantly worse peers domains fine motor problem solving conclusion results indicate applicability asq southern africa point importance early interventions protect early good development african children order promote positive life trajectories
advances treatment idiopathic interstitial pneumonia iip represent urgent unmet medical need patients category diffuse parenchymal lung disease iips involve varying combinations fibrosis inflammation unknown cause may associated pulmonary hypertension occurs associated higher oxygen needs greater functional impairment increased mortality however whether maladaptive versus adaptive phenomenon remains determined despite differing prognoses appear iips may follow similar course supervenes therefore may worthwhile explore studies medications iip group rather individual entities broad approach eliminates need nuance specific diagnoses thereby facilitates study recruitment broadens applicability results published elsevier ltd
background clinicians qualitatively described rhythmic delta activity prominent eeg abnormality individuals angelman syndrome phenotype yet rigorously quantified clinical population validated preclinical model sought quantitatively measure delta rhythmicity evaluate fidelity biomarker methods quantified delta oscillations mouse human using parallel spectral analysis methods measured regional state specific developmental changes delta rhythms patient population results delta power broadly increased dynamic angelman syndrome mouse model relative wild type littermates children angelman syndrome relative age matched neurotypical controls enhanced delta oscillations children angelman syndrome present wakefulness sleep generalized across neocortex pronounced earlier ages conclusions delta rhythmicity phenotypes serve reliable biomarkers angelman syndrome preclinical clinical settings
bayesian networks used decision making software engineering many years fields bioinformatics bns rigorously evaluated terms techniques used build network structure learn parameters extend prior mapping study investigate extent contextual methodological details regarding construction reported studies conduct systematic literature review applications bns predict software quality focus detailed questions regarding dataset characteristics techniques used parameter learning techniques used structure learning use tools model validation techniques results ten primary studies show bns mostly built based expert knowledge structure prior distributions defined experts whereas authors benefit tools quantitative data validate models papers authors clearly explain justification choosing specific technique compare proposed bns machine learning approaches also lack consensus performance measures validate proposed bns compared domains use bns still limited current publications report enough details replicate studies propose framework provides set guidelines reporting essential contextual methodological details bns believe framework would useful replicate extend work bns
control systems control loops closed communication network called networked control system ncs research ncs received increased attention recent years due advancement control computation communication technologies ncs makes design implementation control systems reduced complexity due simpler installation easy maintenance however insertion communication network feedback control loop introduces communication parameters packet dropout degrades control system performance also causes system instability paper describes experimental study ncs form motor control via communication network using markovian jump system approach study existence packet dropout network parameter treated state variable underlying markov chain inclusion packet dropout modelling state space representation whole system renders markovian jump system framework furthermore state feedback controller designed closed loop ncs achieves certain performance feedback gains associated controller calculated solving linear matrix inequalities lmi experimental results show setpoint tracking performance provided switching controller depend existence packet dropout experiment observe greater probability transition packet dropout occurs worse control system performance
last years learned much pathogenesis diagnosis management intestinal fibrosis patients inflammatory bowel diseases decade ago intestinal strictures considered inevitable consequence long term inflammation patients respond anti inflammatory therapies inflammatory bowel diseaseslassociated fibrosis seen irreversible process frequently led intestinal obstructions requiring surgical intervention paradigm changed rapidly due antifibrotic approaches may become available review mechanisms diagnosis serious complication inflammatory bowel diseases well factors predict progression management strategies
although increased interest implicit leadership theories ilts last two decades handful studies examined effects ilt congruence among leader follower dyads important research largely suggested effects ilt congruence focused exclusively prototype congruence examined limited number potential outcomes failed examine questions ilt congruence utilizing appropriate statistical approaches examine effects ilt congruence explicit focus possibility congruence supervisors employees prototypes antiprototypes impacts lmx developed within dyads predict lmx turn affects employees opportunities engage developmental activities using sample matched pairs supervisors employees polynomial regression response surface methodology found congruence supervisors employees prototypes positively influenced lmx also found limited evidence lmx explained effects congruence employees engagement developmental activities although found evidence antiprototype congruence effects supervisors rated antiprototypical traits characteristic leaders lower lmx employees elsevier inc rights reserved
advanced modern processors support single instruction multiple data instructions intel avx arm neon massive body research vector parallel implementations modular arithmetic crucial components modern public key cryptography ranging rivest shamir adleman rsa elgamal digital signature algorithm dsa elliptic curve cryptography conducted paper introduce novel double operand scanning method speed multi precision squaring non redundant representations single instruction multiple data architecture part operands doubled compute squaring operation without read write dependencies source destination variables afterwards karatsuba algorithm applied multiplication squaring operations modular multiplication separated montgomery algorithm chosen finally rivest shamir adleman rsa implementations outperform best known results arm neon platforms copyright john wiley sons ltd
application energy storage offshore renewable generation systems allows managing intrinsic uncertainty resources improving utilization factor electrical network optimal storage design algorithms generally evaluate behavior whole system thousands times converging optimal solution reliability results obviously depends quality input data hand utilization simplified storage models design stage reduce simulation time drastically still providing useful information goal paper evaluate applicability methodology sizing energy storage system hybrid wind wave farm based fluid models description performance modeling approach introduced compared standard design procedures based extensive simulations advantages limitations approach underlined impact input data quality discussed
complexity business dynamics often forces decision makers make decisions based subjective mental models reflecting experience however research shown companies perform better apply data driven decision making creates incentive introduce intelligent data based decision models comprehensive support interactive evaluation decision options necessary business environment recently new general explanation methodology proposed supports explanation state art black box prediction models uniform explanations generated level model individual instance support analysis present novel use methodology inside intelligent system real world case business business sales forecasting complex task frequently done judgmentally users validate assumptions presented explanations test hypotheses using presented parallel graph representation results demonstrate effectiveness usability methodology significant advantage presented method possibility evaluate seller actions outline general recommendations sales strategy flexibility approach easy follow explanations suitable many different applications well documented real world case shows solve decision support problem namely best performing black box models inaccessible human interaction analysis could extend use intelligent systems areas far neglected due insistence comprehensible models separation machine learning model selection model explanation another significant benefit expert intelligent systems explanations unconnected particular prediction model positively influence acceptance new complex models business environment easy assessment switching elsevier ltd rights reserved
results interface shear tests sand geosynthetic interfaces examined light surface roughness interacting geosynthetic material three different types interface shear tests carried frame direct shear test setup compared understand effect parameters like box fixity symmetry interface shear characteristics formation shear bands close interface visualized tests bands analyzed using image segmentation techniques matlab woven geotextile moderate roughness geomembrane minimal roughness used tests effect surface roughness geosynthetic material formation shear bands movement sand particles interface shear parameters studied compared visual observations image analyses image segmentation techniques
metamaterials great potential practical applications stealth technology therefore important understand effect geometrical parameters electromagnetic wave absorption paper dependence absorption certain geometrical parameters metamaterial absorber numerically investigated
findings information seeking behavior research inform application development report provide system description spark application based findings serendipitous knowledge discovery studies data structures known semantic predications background information previously published skd model outlining serendipitous knowledge discovery online environments illustrate potential use information seeking behavior application design detailed overview spark system illustrates methodologies design retrieval functionality enable production semantic predication graphs tailored evoke serendipitous knowledge discovery users published elsevier inc
stator winding structure manufacturing permanent magnet synchronous machines pmsm vital part whole machine design important follow particular procedures order keep winding losses acceptable level include resistance loss additional losses due alternative magnetic flux within area stator winding winding transposition using litz wire effective way proximity loss suppression sometimes implemented due challenges assembling cost aspects especially low cost pmsm solutions case important know consequences using straight non twisting windings pmsms relatively high electrical frequency article studies impact number stator winding parallel strands additional losses distribution slot winding located also thermal condition impacts life time insulation winding analyzed different number parallel strands current temperature distributions slot conductors attained finite element method fem total losses caused additional losses winding compared measurements results
purpose whilst neural morphological adaptations following resistance training investigated extensively group level relatively little known contribution specific physiological mechanisms pre training strength individual changes strength following training study investigated contribution multiple underpinning neural agonist emg qemg mvt antagonist emg hemg antag morphological variables total quadriceps volume quads vol muscle fascicle pennation angle quads well pre training strength individual changes strength weeks knee extensor methods twenty eight healthy young men completed weeks isometric knee extensor week isometric maximum voluntary torque mvt assessed pre post simultaneous neural drive agonist qemg mvt antagonist hemgantag addition quads vol determined mri quads mode ultrasound results percentage changes delta mvt correlated delta qemg mvt delta quads vol pre training mvt delta hemgantag delta quads multiple regression analysis revealed total variance delta mvt explained delta qemg mvt delta quads vol pre training mvt conclusions changes agonist neural drive quadriceps muscle volume pre training strength combined explain majority variance strength changes knee extensor similar adaptations agonist neural drive important single predictor short term intervention
paper aims discuss nursing safety silver needle diathermy treatment ankylosing spondylitis nursed patients ankylosing spondylitis treated silver needle diathermy specific nursing focused physical condition evaluation mental nursing treatment observation treatment diet nursing needle eye nursing functional training propaganda education discharged result suggested patients received mental nursing diet guide skin care health education functional training follow visit nurse could endure silver needle diathermy discomfort drug allergy barely found slight scald skin infection nearby needle eye caused fainting acupuncture accidental puncture overheat follow visit showed patient suffered obvious untoward effect pain joint range motion living condition distinctly improved week discharging conclusion treatment ankylosing spondylitis applying silver needle diathermy nursing treatment obviously reduce complication accelerate recovery highly safe
background parents children autism spectrum disorder asd present wellbeing stress problems parents typically developing children however parents present problems problems due dynamic interaction environmental antecedents person antecedents mediating processes understanding factors separately contribute explain parents well stress implications intervention programs aim study explain parents subjective well physiological stress considering whether child asd child negativity environmental antecedents perception child problems person antecedents use reappraisal mediating processes method thirty seven parents children asd parents children reported subjective well physiological stress assessed additionally children negativity observed parents rated perception child problems autistic traits emotion regulation ability lability negativity parents reported use reappraisal results compared parents children parents children asd reported lower subjective well increased physiological stress parents perceptions children lability negativity parents use reappraisal better predictors parents subjective well asd parents perceptions children lability negativity contributed parents physiological stress much asd conclusions prevention intervention programs targeting parental well stress benefit working parents level perceptual constructs reappraisal ability elsevier ltd rights reserved
diseases sex dependent expressions may etiology prenatal sex hormone exposure specifically prenatal androgens study examined relationship prenatal hormone exposure evidenced ratio life stress potential moderator mediator adult depressive physical health symptoms participants undergraduates diverse backgrounds results indicated masculine ratio associated poorer health males ratio seemed little explanatory power female physical mental health males lower ratio masculine ratio linked clinical cutoff scores depression higher levels life stress greater depression scores addition relationship mediated life stress indicating link masculine ratio depression dependent levels life stress ratio also moderated life stress high levels stress masculine ratio associated physical symptoms overall life stress seemed largest impact physical mental health female participants masculine ratio emerged risk factor men strongly governed context reported stress levels elsevier ltd rights reserved
problems lost translation well known yet terms english managerial vocabulary perfectly translatable languages remain untranslated one explanation phenomenon linguistic anthropology call negative semantic resonances semantic resonances focused issue meanings expressed single word different cultures paper based organisational ethnography latin american expatriates working italo latin american multinational corporation tubworld analyse resonances word leader lider director direttore capo guida coordinador caudillo among group expatriates italian spanish multilingual speakers use english second language everyday interactions paper explains different uses contribute create meaning leader someone leads without leading sometimes manager authors italian native speaker learnt spanish childhood use english everyday language spanish native speaker argue italian spanish speakers avoid words duce caudillo vernacular vocabulary leader use due political cultural meaning also word leader lider resonate two violent authoritarian autocratic antidemocratic leadership furthermore word lexical loan english failed encapsulate complexity leading multilingual organisations like tubworld
paper addresses partial synchronization problem interconnected boolean networks bns via semi tensor product stp matrices first based algebraic state space representation bns necessary sufficient criterion presented ensure partial synchronization interconnected bns second defining induced digraph partial synchronized states set equivalent graphical description partial synchronization interconnected bns established consequently second partial synchronization criterion derived terms adjacency matrix induced digraph finally two examples including epigenetic model provided illustrate efficiency obtained results
myelofibrosis chronic myeloproliferative neoplasm characterized bone marrow fibrosis ineffective hematopoiesis splenomegaly constitutional symptoms shortened survival patients often experience multiple disease associated well treatment emergent cytopenias including thrombocytopenia however patients thrombocytopenia therapeutic options little information management patients several janus kinase jak inhibitors developed treatment one ruxolitinib approved however given mechanism action jak inhibitors associated high rates thrombocytopenia patients successfully managed dose modifications little known safety efficacy agents patients thrombocytopenia recent studies jak inhibitors patients low platelet counts mixed results review discusses prevalence prognostic implications management thrombocytopenia different therapeutic options available patient population emphasis current clinical experience targeted therapies well recent findings several clinical studies currently underway
backgroundfunctional bowel disorders fbds irritable bowel syndrome ibs impact quality life health care resources uncertain whether patients functional digestive symptoms similar characteristics different populations population based study assessed prevalence identified risk factors disorders south east china methodsfive communities selected random invitations distributed representative sample block randomization questionnaires completely supervised investigators demographic medical data fbd symptoms rome iii criteria psychological condition life event stress quality life collected key resultsfunctional bowel disorder prevalence completed questionnaires functional constipation bloating diarrhea ibs ibs ibs ibs ibs unspecified similar numbers men women fbds ibs overall male female however female predominance fbds associated greater anxiety depression life event stress lower quality life compared without symptoms logistic regression identified medical morbidity anxiety depression life event stress independent risk factors disorders conclusions inferencesfunctional bowel disorders common south china western populations similar number men women report fbds ibs prevalent females independent risk factors associated fbds included physical psychosocial stressors
quantify spatial temporal aspects urban heat island uhi effect kanpur major city humid sub tropical monsoon climate gangetic basin fixed station measurements used investigate diurnality inter seasonality urban rural differences surface temperature air temperature separately extent spatial variations nighttime investigated mobile campaigns satellite remote sensing respectively nighttime values dominate pre monsoon maximum monsoon maximum however diurnality different higher daytime values pre monsoon little diurnality monsoon nighttime value mainly associated differences urban rural incoming longwave radiative flux pre monsoon monsoon turn causes difference outgoing longwave radiative flux difference may modulate nighttime value suggested significant correlations pre monsoon monsoon magnitude may also modulated advection inversely related urban wind speed combination situ remotely sensed model simulation data used show inter seasonality lesser extent may related change land use rural site pre monsoon monsoon periods results suggest degree coupling may strong function land use land cover
federation internationale football fifa warm program efficacious preventing lower limb injury youth soccer however poor adoption program community purpose study determine utility health action process approach hapa behavior change model predicting intention use fifa sample youth soccer teams coaches year old female players bespoke cross sectional questionnaire measured pre season risk perceptions outcome expectancies task self efficacy facilitators barriers fifa implementation intention coaches players expected program reduce injury risk reported limited intention use player data demonstrated acceptable fit hypothesized model standardized root mean square residual srmr root mean square error approximation rmsea comparative fit index cfi tucker lewis index tli task self efficacy beta outcome expectancies beta positively associated intention risk perceptions beta findings suggest hapa model appropriate use context highlight need target task self efficacy outcome expectancies fifa implementation strategies
article compares multiple types child maltreatment among puerto rican youth seek expand limited knowledge effects multiple types maltreatment depressive symptoms specific latino population emerging studies indicate children exposed one type maltreatment often exposed types study examines predictive strength different multiple types lifetime child maltreatment physical sexual emotional abuse neglect effect youth support parents youth coping youth self esteem place residence depressive symptoms among puerto rican youth secondary data analyses performed using three annual waves data boricua youth study analytic sample consists year old puerto rican youth living new york puerto rico results indicate youth experienced sexual abuse multiple maltreatment types maltreatment physical abuse significant increase depressive symptoms respectively compared without maltreatment place residence exposure violence mental disorders significant risk factors developing psychosocial interventions professionals particularly focus youth report past lifetime experience child maltreatment particular attention given children living bronx new york similar urban low income areas report past lifetime experience multiple types child maltreatment present symptoms diagnosis occurring mental health problems elsevier ltd rights reserved
milestone women lives menopause source worry anxiety cause certain number physiological changes unwelcome symptoms possible prevent manage pharmacy elsevier masson sas rights reserved
hyperspectral unmixing one important techniques remote sensing image analysis recent years nonnegative matrix factorization nmf method widely used hyperspectral unmixing order solve nonconvex problem nmf method number constraints introduced nmf models including sparsity manifold smoothness etc however constraints ignore important property hyperspectral image spectral responses homogeneous region similar pixel vary different homogeneous regions paper introduce novel region based structure preserving nmf nmf explore consistent data distribution region discriminating different data structures across regions unmixed data method graph cut algorithm first applied segment hyperspectral image small homogeneous regions two constraints applied unmixing model preserve structural consistency within region discriminating differences regions results synthetic real data validated effectiveness method shown outperformed several state art unmixing approaches
video tracking simulation platform important algorithm developer order improve efficiency video tracking algorithm design video tracking simulation platform based mfc many buttons right dialog including open image play start tracking close buttons realize corresponding function platform could show position tracking window working time match degree parameters experimental results show platform complete function video tracking help developers simulate performance processing time different algorithm verify feasible algorithm offer reference algorithm transplant engineering
recent years witnessed development large knowledge bases kbs due lack information content schema semantics kbs users often able correctly formulate queries return intended result paper consider problem failing rdf queries queries return empty set answers query relaxation one cooperative technique proposed solve problem context rdf data several works proposed query relaxation operators ranking models relaxed queries none tried find causes rdf query failure given minimal failing subqueries mfss well successful queries maximal number triple patterns named imal succeeding subqueries xsss inspired previous work context relational databases recommender systems propose two complementary approaches fill gap lattice based approach lba leverages theoretical properties mfss xsss efficiently explore subquery lattice failing query matrix based approach computes matrix records alternative answers failing query triple patterns satisfy skyline matrix directly gives xsss failing query matrix also used index improve performance lba practical interest two approaches shown via set experiments conducted lubm benchmark comparative study baseline related work algorithms
paper presents extension classical gradient based extremum seeking control case disturbances responsible changes extremum selected performance function available measurement based additional measurements adaptive extremum seeking disturbance feedforward designed approximates unknown static mapping disturbances optimal inputs purpose orthogonal multivariate tchebyshev polynomials used feedforward enables extremum seeking conducted proximity extremum thus yielding improvements terms accuracy increased convergence speed compared traditional scheme simulation results given turbine driven electrical generator system demonstrate benefits presented design
idiopathic pulmonary fibrosis ipf devastating lung disease median survival ipf deteriorates upon viral bacterial lung infection although pulmonary infection pneumonia healthy lungs rarely induces fibrosis bacterial lipopolysaccharide lps activates tolllike receptor tlr initiating proinflammatory pathways tlr already linked hepatic fibrosis scleroderma investigated role tlr ipf fibroblasts lung tissue sections patients ipf analyzed tlr expression isolated normal human lung fibroblasts ipf fibroblasts ipf exposed lps transforming growth factor beta tgf beta expression analysis receptors profibrotic mediators cytokines tlr expressed fibroblast foci ipf lungs well primary ipf model gramnegative pneumonia nonfibrotic lung ipf coexposed lps tgf beta whereas produced significantly less connective tissue growth factor upon costimulation compared tgf beta stimulation alone ipf showed significantly increased profibrotic markers compared control fibroblasts costimulation although levels antifibrotic prostaglandin elevated costimulation responsible effect however significant downregulation tgf beta receptor type control fibroblasts seems contribute reduced profibrotic response vitro model normal ipf fibroblasts thus differ profibrotic response upon lps induced tlr stimulation
thiem equation radial groundwater flow well years old still commonly used deviations caused simplifications quantified comparing analytical numerical model allows implementation complex geometries assumption horizontal flow thiem equation necessitates uniform inflow entire screen length fully penetrating well found cause deviations actual pumping wells pump placed screen resulting non uniform inflow additional drawdown applies partially penetrating wells inflow peaks additional drawdown occur especially well screened lower part aquifer use thiem equation near field well thus restricted situations screen inflow relatively uniformly distributed covers large portions aquifer thickness presence gravel pack background gradient hand limited importance
molecular mechanisms causing smoking induced health decline largely unknown elucidate molecular pathways involved cause consequences smoking behavior conducted genome wide gene expression study peripheral blood samples targeting genes data smokers never smokers smokers available two population based cohorts netherlands addition data monozygotic twin pairs discordant ever smoking used one hundred thirty two genes differentially expressed current smokers never smokers bonferroni correction significant genes protein coupled receptor leucine rich repeat neuronal smoking related genes enriched immune system blood coagulation natural killer cell cancer pathways taking data smokers account expression genes classified reversible genes slowly reversible genes irreversible genes inconclusive gene expression genes three reversible three slowly reversible confirmed reactive smoking differentially expressed monozygotic pairs discordant smoking cis expression quantitative trait loci gpr rarres downregulated smokers associated increased number cigarettes smoked per day large genome wide association meta analysis suggesting causative effect gpr rarres expression smoking behavior conclusion differential gene expression patterns smokers extensive cluster several underlying disease pathways gene expression differences seem mainly direct consequences smoking largely reversible smoking cessation however also identified dna variants may influence smoking behavior via mediating gene expression
background purpose work determine safety feasibility noninvasive support children acute respiratory failure arf interhospital ground transport methods prospective single center observational clinical study pediatric transport unit tertiary care pediatric hospital included subjects arf transported november march specific noninvasive support protocol used cases transport ventilators used crossvent oxylog interfaces oronasal mask nasopharyngeal tube nasal prongs results total children diagnosed arf transported fifty four subjects transported invasive ventilation cpap niv oxygen cannula nebulization median age months interquartile range months arf mainly due bronchiolitis asthma pneumonia stabilization time defined time arrival parking lot referring hospital departure lower noninvasive support invasive ventilation median min min median transport time min interquartile range noninvasive ventilation oronasal interface use rose progressively study period niv interface one complication observed one subject required intubation transport evolution subjects transferred receiving noninvasive support recorded receptor hospitals subjects intubated continued niv conclusions niv seems safe feasible technique pediatric ground transport careful patient selection adequate material well trained transport team crucial minimize risks patient
according attachment theory bowlby individual differences adult attachment styles based attachments formed infancy primary caregivers adults form secure attachments feel safe secure relationships form insecure attachments according self compassion theory neff supported research self compassion compassionate attitudes behaviors towards oneself associated variety positive psychological outcomes lack self compassion associated psychological distress barnard curry additionally fear self compassion negatively associated self compassion joeng turner current study extend research attachment self compassion examining self compassion fear self compassion mediate two types insecure attachment styles anxious attachment avoidant attachment two indicators emotional distress depression anxiety among korean college students structural equation modeling indicated self compassion independently mediated fear self compassion self compassion serially mediated paths anxious avoidant attachment depression anxiety expected directions results interpreted perspective korean culture including influence confucianism expression self compassion elsevier ltd rights reserved
rapid development country economy per capita level material life improved significantly corresponding power consumption also growing sharply brings severe test stable operation power grid system mainstream trend current power grid construction intelligent substation gathers many advanced technologies wherein communication technology plays significant role ensure communication network security become currently primary work content thus article mainly analyzes communication security technology intelligent substation objectively sets forth structure intelligent substation integrating actual situation puts forward safer reliable technical solution according characteristics ied provide solid guarantee intelligent substation make sure data transmission securer promote healthy sustainable development power utility
nowadays computer network universally used various sectors brings convenience sectors also changes people lifestyle arrival information age people become increasingly dependent computer network therefore security computer network becomes issue worth increasing attention advices improve reliability computer security computer network put forward paper universal application computer network represents cultural progress human society brings convenience people improves working efficiency degree people dependence computer network increasing improvement network information technology therefore people higher requirements security anti interference computer network present security anti interference computer network among important issues researched network developers concerned large number network users speak reliability network security become basic requirement people using computers realize obvious improvement reliability computer network ensure computers provide better services people great significance research
steam injection turbocompouding effective methods engine waste heat recovery fuel saving potential obtained combination two methods clear based turbocompound engine developed previous study impacts pre turbine steam injection fuel saving potentials turbocompound engine investigated paper firstly thermodynamic cycle model baseline turbocompound engine established using commercial software power cycle model calibrated experiment data turbocompound engine achieves high accuracy influences steam mass flow rate evaporating pressure injection location engine performance studied addition impacts hot liquid water injection also investigated results show steam injection turbocharger turbine inlet reduce turbocompound engine bsfc speed conditions largest fuel reduction obtained rpm condition however steam injection power turbine inlet lower bsfc high speed conditions besides found hot liquid water injection exhaust improve engine performance compared conventional turbocharged engine combination turbocompounding steam injection reduce bsfc different speeds elsevier ltd rights reserved
role trough serum infliximab ifx antibodies toward ifx ati maintenance treatment remains unclear children aim present study investigate trough ifx ati identify correlation inflammatory activity clinical response pediatric inflammatory bowel disease ibd cohort investigated ifx trough levels pediatric ibd patients maintenance ifx treatment ninety three blood samples collected demographics reactive protein crp erythrocyte sedimentation rate esr albumin recorded mean ifx trough level mean trough ifx level significantly higher samples taken remission compared active disease trough ifx levels correlated esr crp albumin ifx undetectable eight patients positive ati active disease surprisingly clinical biochemical remission observed visits correlation dose variations changes trough ifx evident line studies adults ifx trough levels correlated response infliximab
background impairment prediction appreciation choice outcomes could contribute several core symptoms asd examined electroencephalography eeg oscillations youth young adults diagnosed autism spectrum disorder asd matched neurotypical controls performed chance based reward prediction task method analyzed previously published erp data larson examined theta band oscillations frontal midline sites within timing window overlaps feedback related negativity frn focused event related changes presentation feedback reward win punitive lose outcomes spectral power inter trial phase coherence results reward prediction task groups medial frontal theta power phase coherence greater following lose compared win feedback however compared controls inter trial coherence medial frontal theta significantly lower overall across feedback types individuals asd results indicate individuals asd sensitive valence reward feedback comparable neurotypical peers reduced synchronization medial frontal theta activity feedback processing conclusions finding consistent previous studies showing neural variability asd suggest processes underlying decision making reinforcement learning may atypical less efficient asd elsevier ltd rights reserved
clinical morphological study myelofibrosis carried patients chronic lymphocytic leukemia debut disease trephinobiopsy specimens ileac bone aspirated specimens bone marrow peripheral blood smears studied patients chronic lymphocytic leukemia associated myelofibrosis different severity cases morphometric analysis trephinobiopsy specimens showed severity histology dissemination myelofibrosis correlated type tumor involvement bone marrow focal tumor involvement bone marrow predominated trephinobiopsy specimens patients without myelofibrosis patients myelofibrosis developed mainly diffuse tumor infiltration associated greatest dissemination initial manifest myelofibrosis myelofibrosis found patients interstitial tumor involvement bone marrow severity initial manifest myelofibrosis directly correlated tumor involvement bone marrow peripheral blood evaluation prognosis showed initial myelofibrosis associated disease standing months manifest condition disease months longer
full scale measurement structural dynamic characteristics vortex induced vibrations viv long span suspension bridge central span conducted different finite element modeling principles separated twin box girder compared evaluated field vibration test results double spine model determined best simulation model certain modification still needs made affect basic modeling parameters dynamic response prediction values corresponding wind tunnel tests based modal analysis results small scaled large scaled sectional model tests carried investigate viv responses probable reynolds number effects scale effect viv responses presented based observed viv modes field measurement viv results obtained sectional model tests converted three dimensional full scale bridge subsequently compared field measurement results indicated large scaled sectional model test probably provide reasonable effective prediction viv response
patent foramen ovale pfo communication across inter atrial septum right atrial septal pouch rasp indentation atrial septum caused incomplete fusion septum primum septum secundum base opening right atrium year old male history two strokes episodes transient neurological deficit diagnosed small right left shunt time pfo closure angiogram atrial septum revealed small pfo associated rasp small pfo crossed straight tipped guide wire closed using gore cardioform septal occluder gore associates hypothesized stagnant blood rasp may generate clot cross pfo cause infarct wiley periodicals inc
background little known anorectal function quality life chemoradiation followed local excision alternative total mesorectal excision selected patients early rectal cancer objective purpose study prospectively assess anorectal function health related quality life patients rectal cancer treated alternative approach design prospective phase trial settings study multicentric american college surgeons oncology group trial interventions patients stage ctn rectal adenocarcinomas treated oxaliplatin capecitabine based chemoradiation regimen followed local excision main outcome measures anorectal function quality life assessed enrollment year postoperatively fecal incontinence severity index fecal incontinence quality life scale functional assessment cancer therapy colorectal questionnaire results compared multivariable analysis performed identify predictors outcome results seventy one patients evaluated enrollment year compared baseline significant differences found fecal incontinence severity index scores year fecal incontinence quality life results significantly worse lifestyle coping behavior embarrassment domains differences functional assessment cancer therapy overall score physical wellbeing subscale significantly worse emotional well improved surgery treatment original chemoradiation regimen predicted worse depression self perception embarrassment scores fecal incontinence quality life male sex predictive worse scores functional assessment cancer therapy overall score trial outcome index limitations small sample size relatively short follow absence information cancer diagnosis study limitations conclusions chemoradiation followed local excision minimal impact anorectal function year surgery overall quality life remained stable mixed effects different subscales information used counsel patients expected outcomes
assess impact child symptoms autism spectrum disorder upon parents anxiety depression mothers boys aged years years years completed asd behaviour checklist gad phq single setting results indicated boys restricted repetitive behaviours strongest relationship mothers anxiety depression followed communication difficulties latter set behaviours significantly add variance predicted restricted repetitive behaviours sons intense reactions stressors powerful asd related contributor anxiety depression experienced mothers several suggestions enhancing parental coping aspect child asd behavioural symptomatology discussed
thermo electric modules tems used convert heat electricity utilizing seeback effect possible buy bite thermo electric modules operate temperatures around degrees however many applications harvesting excess gas turbine heat may occur higher temperatures therefore new materials manufacturing processes need developed produce packaged tems operate maximum operating temperature degrees two critical areas manufacture sige tem choice strength materials used sintered joint material rest module metal used interconnects interconnection material needs sufficiently strong withstand large temperature fluctuations maintaining low contact resistance well compatible nano sintered joint shear force tests sintered thermo electrical leg material showed joints brittle sintered metallized substrates used ductile fracture behavior sintered metallized substrates using nanotach nano silver paste almost joints found brittle using nachtach nano silver paste shear testing sintered joints showed paste joints variable strength stiffness typical young modulus mpa room temperature paste joints stiffer similar strength compared paste joints elsevier ltd rights reserved
attic spaces one dynamic components building envelope engineers designers architects contractors utilize different attic designs materials mechanical equipment attic spaces optimize attic thermal energy performance meet needs home owners codes standards design attic spaces becomes extremely important considering energy usage simple changes often drastically change energy characteristics long term durability performance historically interest focused attic spaces gable ends materials constant thermal properties however recent years seen increasing interest geometrically complex roofs novel materials tailored building envelop modification state art attic simulation software include changes difficult since software developments date back paper discusses development verification fraunhofer attic thermal model fatm fatm numerical predictions verified benchmark thermal problems energy load calculation software fatm several novel features including capability analysis convex non convex attic geometries incorporation temperature dependent material properties temperature dynamics conditioned space careful software engineering informed approach build generic modular flexible numerical framework contributions paper increase applicability framework larger percentage attic spaces around world allow future changes framework easily made introduce methods create modular framework implement whole building simulation programmes newly developed approach determining energy loads attic spaces form attic spaces novel material construction systems easily explored
increasingly expensive polluting sources energy dictate need energy conservation society major energy consumption contribution operation phase modern buildings hvac systems well planned hvac systems may provide healthy comfortable indoor environment poor design may result wastage energy traditionally design systems based constant number occupants situational awareness system ignored paper focuses intelligence hvac system terms knowledge occupants facility real time thermal comfort analysis applied study indoor climate buildings efficient use hvac systems computational fluid dynamics cfd used model simulate indoor conditions building information modelling bim used platform integrate data apply spatial analysis green building standards embedded bim model evaluate building sustainability based results reasonable allocation individual location room provided automatic control lighting air conditioning suggested optimize energy consumption based matching occupants comfort level
background aims insulin resistance associated cluster abnormalities increase cardiovascular disease cvd several indices proposed identify individuals insulin resistant thereby increased cvd risk aim study compare abilities indices accomplish goal plasma triglyceride glucose index plasma triglyceride high density lipoprotein cholesterol ratio hdl metabolic syndrome mets methods results population sample individuals women men years old respectively baseline demographic metabolic variables known increase cvd risk incident cvd compared among individuals defined high low risk hdl mets cvd risk profiles appeared comparable high risk subjects irrespective criteria crude incidence cvd events increased high risk subjects subjects years defined hdl subjects years defined subjects years subjects mets area roc curves predict cvd similar hdl respectively however adjusted age sex multiple covariates hazard ratios incident cvd significantly increased high risk patients classified either hdl ratio mets index conclusion although indices identify cvd risk comparably index seems somewhat less effective predicting cvd italian society diabetology italian society study atherosclerosis italian society human nutrition department clinical medicine surgery federico university published elsevier rights reserved
present study used eyetracking methodology assess whether individuals high external motivation appear nonprejudiced exhibit early bias visual attention toward black faces indicative social threat perception drawing previous work examining visual attention socially threatening stimuli authors predicted high participants lower participants would initially look toward black faces subsequently direct attention away faces participants viewed pairs images consisted one white one black male face desk mounted eyetracking camera recorded eye movements results showed predicted high lower individuals exhibited patterns visual attention indicative social threat perception
propose novel parallel computing framework nonlinear finite element method fem based cell model apply simulate avascular tumor growth derive computation formulas simplify simulation design basic algorithms increment proliferation generations tumor cells fem elements may become larger distorted describe remesh refinement processing distorted large finite elements parallel implementation based message passing interface improve accuracy efficiency simulation demonstrate feasibility effectiveness fem model parallelization methods simulations early tumor growth
mir family involved fibrosis multiple organs including intestine mir facilitates tgf beta mediated regulation collagen mucosal fibroblasts crohn disease patients myeloid cell leukemia mcl member cell cll lymphoma bcl apoptosis family involved liver fibrosis targeted mir via utr cultured cell lines investigate role mcl mir primary intestinal fibroblasts tissue stricturing patients transfection intestinal fibroblasts pre mir resulted significant increase mrna expression mcl isoforms mcl long extra short mcl short although mcl expressed significantly lower levels western blotting predominantly detected anti apoptotic mcl isoform immunofluorescence showed staining localised discrete nuclear foci transfection pre mir anti mir resulted significant increase decrease respectively mcl foci fibroblasts treated inflammatory cytokines upstream mcl increased total mass mcl positive foci furthermore transfection intestinal fibroblasts pre mir resulted increase mrna protein levels finally immunohistochemistry showed reduced mcl protein expression fibrotic samples compared non stricturing controls together findings suggest induction mcl may surmount direct regulation mir via utr propose anti fibrotic mir mcl axis may influence intestinal fibrosis future therapeutic modulation pathway might contribute management fibrosis
background literature suggested adhd may associated increased risk obesity would important clinical implications objective clarify size association adhd obesity evaluate key moderators association including medication gender age psychiatric comorbidity method two preliminary studies presented supply critical additional data meta analysis two year longitudinal study adhd case control sample children aged national survey study families united states using national survey children health formal meta analysis conducted identification procedure yielded studies reporting comparisons effect sizes studying participants overall effect size estimated random effects model pooling within study using modified fixed effects model effect size examined relation medication gender age psychiatric comorbidity results new study children revealed reliable association adhd body mass index age time point national survey adhd associated obesity adolescent girls children boys effect statistically accounted covarying depression conduct disorder meta analysis composite effect size studies provided effects medication controlled yielding composite effect size pooled across age association without covariates reliable females males although males females statistically differ pooled across gender association significantly larger adults years youth conclusions adhd small overall association obesity effect moderate adults effect likely clinical significance children possible clinical significance adolescent girls comorbid disorders clinical relevance adulthood elsevier ltd rights reserved
introduction trem lipid sensing activating receptor microglia known important alzheimer disease whether plays beneficial detrimental role disease pathogenesis controversial methods analyzed risk trem variants nimh genetics initiative study sequencing project compared variant risk functional impact reporter assay finally analyzed expression trem human monocytes results provide evidence increased risk associated several trem variants show variants decreased markedly increased binding trem ligands identify hdl ldl novel trem ligands also show trem expression human monocytes minimal compared monocyte derived dendritic cells discussion results suggest trem signaling helps protect cause harm excess supporting idea proper trem function important counteract disease progression alzheimer association published elsevier inc rights reserved
objective although cognitive behavioral therapy cbt represents first line evidence based psychotherapy bulimia nervosa individuals seeking treatment access specialized intervention compared internet based manualized version cbt group therapy conducted via therapeutic chat group cbtbn treatment conducted via traditional face face group therapy cbtff method two site randomized controlled noninferiority trial tested hypothesis cbtbn would inferior cbtff total adult patients males received sessions group cbt weeks either cbtbn cbtff outcomes compared end treatment month follow results end treatment cbtbn inferior cbtff producing abstinence binge eating purging however month follow cbtbn mostly inferior cbtff participants cbtbn condition cbtff continued reduce binge eating purging frequency end treatment month follow conclusions cbt delivered online group chat format appears efficacious treatment although trajectory recovery may slower face face group therapy online chat groups may increase accessibility treatment represent cost effective approach service delivery however barriers service delivery state specific license ethical guidelines online therapists need addressed karger basel
past research shown rapport cooperation individuals related level nonverbal synchrony achieve interactions study investigates extent staff clients mild borderline intellectual disability achieve interactional synchrony daily social interactions whilst work examining staff adapt verbal communication help achieve better mutual understanding absence work concerning responsiveness staff clients regarding nonverbal behavior nineteen staff members video recorded social interaction one clients client need support recordings analyzed using cross recurrence quantification analysis addition fifteen staff members well clients intellectual disability completed questionnaire quality nineteen video recorded interactions analysis nonverbal patterns interaction showed staff client dyads achieved interactional synchrony synchrony pervasive nonverbal behaviors client observers appeared sensitive synchrony value highly staff raters staff observers sensitive quantitative measures talking staff interactions talked lower quality rating interaction clients talked positively staff observers rated interactions findings implications collaborative relationships clients support workers understood
modern therapeutics chemically synthesized drugs reported causing adverse effects including allergies rashes itches swelling past decades silver nanoparticles agnps widely applied medical domains due antimicrobial wound healing properties present study different concentrations phytosynthesized agnps saturated cotton dress fabrics comparison cotton fabrics treated commercial ointment tested days assess ability speed healing rats burn wounds significant difference body weight observed course treatment compared normal rat group cotton fabrics observed scanning electron microscopy sem confirmed distribution agnps cotton fibers energy dispersive ray analysis edx spectrum also authenticated agnps distribution end experimental period wound healing efficacy dressing containing commercial ointment burn heal slightly lower treatment containing body weight agnps additionally also observed wound contraction area higher positive drug treated group indicates comparatively better quality activity ointments agnps regards burn healing properties histological sem observations showed better fibril alignments repaired skin compared negative positive control groups perhaps due tensile strength comparatively higher concentration nanoparticles groups contained nanoparticles groups showed much better healing properties positive drug treated group altogether increased concentration agnps show increased recovery action comparison positive drug treated group study provides additional insight incorporation agnps wound dressings speedy recovery burn wounds improved human welfare elsevier rights reserved
box plays imperative role designing cryptographically strong block cipher designing box based chaos attracted lots attentions distinct characteristics relevant cryptography paper wing hyperchaotic system investigated sophisticated nonlinear behaviors used generate two pseudorandom bit integer sequences drive iterative two position swap identical map according indicator typical evaluation criteria including nonlinearity differential uniformity strict avalanche criterion output bits independence criterion bijective property preferred box obtained batch generated ones comparison state art chaos based schemes shows obtained box achieves better cryptographical performance
introduction frequency domain nonlinear subspace identification fnsi method constitutes one series recent attempts toward developing realistic first generation framework applicable complex structures method showed promising capabilities applied academic structures still confronted number limitations needs addressed particular removal nonphysical poles identified nonlinear models distinct challenge present paper proposed first contribution operate directly identified state space matrices carry spurious pole removal modal space decomposition state output matrices examined discriminate genuine numerical poles prior estimating extended input feedthrough matrices final state space model thus contains physical information naturally leads nonlinear coefficients free spurious variations besides spurious variations due nonphysical poles vibration modes lying outside frequency band interest may also produce drifts nonlinear coefficients second contribution paper include residual terms accounting existence modes proposed improved fnsi methodology validated numerically experimentally using full scale structure morane saulnier paris aircraft elsevier ltd rights reserved
work proposes novel physics based model fluid mechanics heat transfer associated slug flow boiling horizontal circular microchannels update widely used three zone model thome heat transfer model convective boiling nature predicts time dependent variation local heat transfer coefficient cyclic passage liquid slug evaporating elongated bubble vapor plug capillary flow theory extended incorporate evaporation effects applied estimate bubble velocity along channel liquid film thickness prediction method also considering bubble proximity effects may limit radial extension film included minimum liquid film thickness dryout set channel wall roughness theoretical heat transfer models accounting thermal inertia liquid film recirculating flow within liquid slug utilized heat transfer model compared experimental data taken three independent studies slug flow boiling data points cover fluids rfa rfa channel diameters proposed evaporation model predicts database within demonstrates stronger contribution heat transfer liquid slugs correspondingly less thin film evaporation process compared original three zone model model represents new step towards complete physics based modelling bubble dynamics heat transfer within microchannels evaporating flow conditions elsevier ltd rights reserved
many data pre processing techniques aim enhancing quality classifiers induced machine learning algorithms functional expansions one techniques originally proposed aid neural network based classification despite successfully employed works reported literature use functional expansion expansion size applied attribute describes training data paper argued attribute oriented choosing suitable pair attribute input data representation improves consequence learning algorithms induce better classifiers paper proposes pre processing step learning algorithms method uses genetic algorithm searching suitable pair data attribute aiming producing functionally extended training data experimental results using functionally expanded training sets considering four classification algorithms knn cart svm rbnn confirmed hypothesis proposed method searching pairs attribute oriented fashion yielded statistically significant better results learning original data considering result best pair attributes elsevier rights reserved
functional cognitive framework psychological research implies functional cognitive researchers operate two separate mutually supportive levels explanation functionalcognitive perspective applied psychologists ultimately directed functional level differ way conduct functional research degree seek guidance cognitive models propose taxonomy encompasses four different types applied psychology evaluate merits type also argue applied psychology fortified strengthening functional core thus evolving integrated still diverse discipline psychological engineering finally explore implications ideas applied memory research
human like motion prediction simulation important task many applications fields occupational biomechanics ergonomics industrial engineering study biomechanical systems prevention musculoskeletal disorders computer graphics animation articulated figures prosthesis exoskeletons design well design control humanoid robots among others effort get biomechanical insight many human movements extensive work conducted last decades human motion prediction tasks walking running jumping standing chair reaching lifting literature review focused sts motion llm sts defined process rising chair standing position without losing stability balance ubiquitous torque demanding daily labor closely related capabilities human body llm defined activity raising load generally box low higher position stability maintained task produces high number incidences low back pain injuries many industrial domestic activities order predict sts llm two methods identified obmg method cbmg method
interaction simulations particles structures often performed context combined discrete finite element dem fem method efficient robust accurate contact algorithm challenging contact problems essential three dimensional discrete finite element contact algorithm named zgl proposed research group zang contact algorithm discrete finite element contact problems based penalty function method comput mech despite quite well established zgl algorithm may lack efficiency robustness accuracy certain situations special mesh pattern applied however since cases readily appear practice engineering application algorithm named dzceii developed resolve issues thus significantly applicable challenging contact problems proposed dzcell algorithm includes improved global phase directly find potential segments rather nearest node discrete elements contact counterparts furthermore memory cost time consumption algorithm linear algorithm readily extend parallel computing several numerical examples demonstrate achievable improvements terms efficiency robustness accuracy contact analysis validate capability dzceii algorithm granular science mechanical engineering elsevier rights reserved
crowdsensing attracted attention recent years help companies data demanders collect large amounts data efficiently cheaply crowdsensing system sensing tasks divided many small sub tasks easily accomplished smartphone users companies take advantage data collected smartphone users improve quality services efficient task assignment mechanism design critical crowdsensing realistic constraints however existing studies task assignment issue still many limitations failed consider time budget smartphone users therefore work studies optimal task assignment problem crowdsensing systems maximize task completion rate consideration time budget users also prove optimal task assignment problem hard thus adopt linear relaxation greedy techniques design near optimal crowdsensing task assignment mechanism also empirically evaluate mechanism show proposed task assignment mechanism efficient
plantago ovata forsk annual herb immense medicinal importance seed husk used treatment chronic constipation irritable bowel syndrome diarrhea since ancient times zinc essential metal required plants form important components zinc finger proteins also aid synthesis photosynthetic pigments chlorophyll however excess amount causes chlorosis leaf shoot tissues generate reactive oxygen species present study aimed investigating changes expression levels gene plantago ovata zinc stress data show fold increase expression pomt znso center dot treated sample study also describes alteration gene expressions plantago ovata observed real time pcr qpcr done method study observed upregulation induction pomt gene expression level znso center dot treated samples found saturation increasing dose znso center dot determination phenotypic biochemical changes plantago ovata due exposure zinc stress concentrations revealed oxidative stress enhanced expression gene plantago ovata correlation increased total antioxidant activity increased dpph radical scavenging activity
polybia idwkklldaakqil lytic peptide brazilian wasp venom known anti cancer properties previous evidence indicates phosphatidylserine lipids relevant lytic activity mpl agreement requirement phosphatidylserine lipids translocated outer leaflet cells available binding depending presence liquid ordered domains investigated effect activity lipid reconstituted membranes giant large liposomes different lipid phase states monitoring membrane soluble luminal content giant unilamellar vesicles guvs using fluorescence confocal microscopy able determine pore forming activity membrane level liquid ordered domains phase separated within membrane guvs influenced pore forming activity mpl experiments evaluating membrane binding lytic activity large unilamellar vesicles luvs lipid composition guvs demonstrated synergy liquid ordered domains enhanced activities based findings propose physicochemical properties cancer cell membranes possess much higher concentration normal cells renders susceptible binding lytic pore formation results correlated potent selective anti cancer activity pave way future research develop cancer therapies harness exploit properties elsevier rights reserved
wavelet frames appropriate alternative approach signal approximation especially noise vibration signals paper presents active noise control scheme using various wavelet frames innovative structure structure authors employ nonlinear static mapping cascaded infinite impulse response filter model dynamic part network online dynamic back propagation learning algorithms applied based gradient descent method adjust network parameters simulations carried compare performance filtered least mean square filtered back propagation neural network algorithms proposed method experiments designed conducted evaluate developed algorithms simulation experimental results show superior performance proposed method terms fast convergence rate noise attenuation avoiding curse dimensionality
objective undiagnosed atrial fibrillation patients high risk cardioembolic stroke complications aim study analyze blood volume pulse bvp signals obtained wristband device develop algorithm discriminating normal sinus rhythm nsr arrhythmias arr approach thirty patients arr nsr included study recordings obtained rest empatica wristband device lasted min analysis min segment included spectral variability irregularity analysis performed inter diastolic interval series similarity analysis performed bvp signal main results significance variability parameters highest lowest nsr intermediate arr example pnn values respectively similarity parameters highest nsr lowest intermediate arr example using threshold assessing similarity rhythm classification preceded sampling using synthetic minority sampling technique class arr smallest class features selection performed using sequential forward floating search algorithm identified two variability parameters pnn pnn best selection classification nearest neighbor classifier reached accuracy nsr arr using pnn pnn specificity three rhythms spnsr spaf sparr sensitivity spnsr spaf sparr
system software engineering development unforeseen changes occurring process enactment almost inevitable often poorly managed due lack efficient mechanisms spontaneously handling run time changes proposed change aware process management system allows process actors reporting emergent changes analyzing possible impacts notifying people affected changes end integrated change management component process management system process management system monitors process enactment uses run time process information construct process dependency graph pdg representing dependencies among elements running processes change management component captures change requests sent asynchronously reasons pdg determine impacted elements pdg reflects information process instances therefore uncover intra process inter processes dependencies invisible process models implemented prototype named cape based platform jbpm graph database neoj copyright john wiley sons ltd
endosomal sensing represents key strategy mammalian cells detect parasitization invading pathogens critical control fungal pathogens part phagocytosed effector cells innate immune system despite rapid overall progress understanding endosomal responses recent times relatively little known endosomal sensing system detects fungi ensuing immunological consequences considering many fungal pathogens must overcome evade endosomal killing order survive host understanding key area early innate response crucial understanding fungal infection review present summary current knowledge endosomal sensing within context fungal pathogens focus myeloid compartment
background bright light treatment effective seasonal affective disorder sad although mechanisms action still unknown investigated whether transcranial bright light via ear canals antidepressant effect treatment sad methods four week study period patients females males aged mean age years suffering sad randomized receive min daily dose photic energy one three intensities lumen lumens lumens via ear canals light produced using light emitting diodes severity depressive symptoms assessed hamilton depression rating scale seasonal affective disorder sigh sad hamilton anxiety rating scale hama beck depression inventory bdi cognitive performance measured trail making test tmt within group group changes variables throughout study analysed repeated measures analysis variance anova whereas gender differences baseline within light groups analysed using student tests results patients three groups showed significant decreases bdi hama sigh sad scores response rates least decrease symptoms measured bdi three treatment groups corresponding variations sigh sad hama respectively intensity based dose response relationships improvement anxiety depressive symptoms cognitive performance treatment groups observed approximately one four patients experienced mild adverse effects common headache insomnia nausea conclusions results suggests transcranial bright light treatment may antidepressant anxiolytic effect sad patients self psychiatrist rated depressive anxiety symptoms decreased treatment groups improvements comparable findings earlier bright light studies used conventional devices lack dose response may due saturation effect certain light intensity threshold studies effects transcranial bright light adequate placebo condition needed
reduced energy consumption key aspect green building nonetheless research indicates performance gap predicted actual energy performance buildings occupied implies cost deviation anticipated energy cost performance however cost deviation also might result lower higher energy rates expected appropriate research methodology existing theory testing case study research strategy adopted empirically examine earned value management evm approach measure actual life cycle cost performance energy green buildings slight methodological terminological adaptations found evm approach applied conduct holistic cost performance measurement actual energy consumption green buildings strength earned value approach allows detecting whether energy cost saving overrun results lower higher energy consumption actual energy rate variations earned value approach allows quantifying cost variance independently significant aspect actual energy cost performance measurement green buildings
paper cascade control architecture brake wire system suitable motor racing applications described system composed electromechanical actuator electric motor transmission master cylinder traditional hydraulic brake pipe caliper starting control oriented model cascade control proposed innerloop controls position outer pressure outer loop features adaptation mechanism cope intrinsic timevarying nonlinearity position pressure relationship stability robustness pressure loop proven extensive experimental validation conducted instrumented motorbike test circuit professional rider shows performance system
nowadays securing data become prime concern educational institutes workplaces etc usb drives largely used storing transferring data due large capacity nominal cost high transferring rate portability drives used store data also ability run software programs boot operating systems besides several advantages usb drives misused stealing data injecting viruses trojans malicious software system invent technology runs based auto run facility operating system become possible copy data without owner knowledge paper provides solution safeguard data thefts without using physical methods like using superglue block usb ports without altering registry values without using bios method
background number cancer survivors growing negative physical psychosocial consequences cancer treatment occur survivorship following healthy lifestyle recommendations beneficial increase quality life reduce risk cancer recurrence comorbidities meet individual needs web based interventions supply large population cancer survivors easily accessible personalized information evidence concerning long term effects web based cancer aftercare interventions lifestyle outcomes limited present study evaluates month effects fully automated web based cancer aftercare intervention investigated whether previously determined month effects moderate physical activity vegetable intake maintained months possible moderator effects using specific intervention modules gender age education also explored method two armed randomized controlled trial conducted using online self report questionnaires among survivors various types cancer intervention group access online intervention months control group received access months multilevel linear regression analyses complete cases intention treat conducted explore month effects results significant intervention effect months found moderate physical activity complete cases intention treat age significant moderator intervention effective among participants aged younger years significant intervention effect remained vegetable consumption months complete cases intention treat conclusion online cancer care intervention effective increasing maintaining moderate physical activity long term among early cancer survivors younger years short term increases vegetable consumption sustained long term findings indicate value potential ehealth interventions cancer survivors based study results web based self management interventions could recommended younger cancer survivors years age possible method increase physical activity
non alcoholic fatty liver disease nafld associated obesity insulin resistance type diabetes cardiovascular disease considered hepatic manifestation metabolic syndrome nafld represents spectrum disease relatively benign simple steatosis serious non alcoholic steatohepatitis progress liver cirrhosis hepatocellular carcinoma end stage liver failure necessitating liver transplantation although increasing prevalence nafld developed countries substantial implications public health many precise mechanisms accounting development progression nafld unclear environment early life important determinant cardiovascular disease risk later life studies suggest also extends nafld review data animal models human studies suggest fetal early life exposure maternal overnutrition excess glucocorticoids environmental pollutants may confer increased susceptibility nafld development progression offspring effects may sex specific also consider studies aimed identifying potential dietary pharmacological interventions aimed reducing risk suggest human epidemiological studies needed ensure data animal models relevant human health
objective eating disorders eds serious health problems affecting college students article aimed estimate costs united states dollars stepped care model online prevention treatment among college students inform meaningful decisions regarding resource allocation adoption efficient care delivery models eds college campuses methods using payer perspective estimated costs delivering online guided self help gsh intervention individuals eds including costs stepping proportion expected fail delivering online preventive intervention compared wait treat approach individuals risk applying stepped care model across population students compared standard care results combining results online gsh preventive interventions estimated stepped care model would cost less result fewer individuals needing person psychotherapy receiving less intensive intervention compared standard care assuming everyone need received intervention conclusions stepped care model estimated achieve modest cost savings compared standard care estimates need tested sensitivity analyses model assumptions highlight complexities cost calculations inform resource allocation considerations disseminable delivery model presented efforts needed systematically measure costs benefits stepped care model eds college campuses improve precision efficacy interventions apply calculations non care systems different cost structures
mountainous vegetation recovery major earthquakes important implications preventing postseismic soil erosion geo hazards however regional recovery processes postseismic vegetation spatial patterns thoroughly studied paper examined vegetation recovery processes following wenchuan earthquake using day intervalmodis normalized difference vegetation index time series savitzky golay filter cross correlogram spectral matching used eliminate influences cloud intraannual phenology change vector analysis applied measure postseismic vegetation recovery conditions year find heavily affected vegetation areas mainly located along southern part earthquake surface rupture additionally five major affected vegetation types identified shrubland grassland broadleaf mixed needleleaf plantation shrubland represents largest fraction vegetation type heavily affected area whereas plantation comprises smallest fraction vegetation type heavily affected area analysis indicates changing trend postseismic vegetation conditions first six years grouped three classes recovering fluctuating deteriorating recovering fluctuating classes cover heavily affected areas respectively two dominant postseismic vegetation classes contrast deteriorating recovery class covers affected areas recovering vegetation primarily located around epicenter fluctuating classes located northeast epicenter results demonstrate wenchuan earthquake long term important influences mountain vegetation andmore attention given locations deteriorating fluctuating vegetation following mountain disasters
associated prime number generalized bilinear operators adopted yield extended kadomtsev petviashvili like ekp like equation symbolic computation eighteen classes rational solutions resulting ekp like equation generated search polynomial solutions corresponding generalized bilinear equation elsevier ltd rights reserved
purpose assessed lower urinary tract symptoms lutss clinical outcomes diabetes mellitus patients non diabetic non patients receiving transurethral resection prostate tur methods analysis retrospective cohort study using years claims data taiwan national health insurance research database nhird total patients persistent lutss underwent tur prostate enlargement benign prostate enlargement bpe enrolled divided two groups non groups patients characteristics postoperative clinical outcomes medication records tur compared chi square test used categorical variables independent samples test continuous variables multivariable logistic regression analysis used compare risk postoperative outcomes finally estimated medication free survival rate tur using kaplan meier method compared study groups using log rank test results group patients higher prevalence comorbidities postoperatively group lower rates urinary tract infection uti odds ratio higher rates urinary retention requiring catheterization within month tur higher proportion patients took anti muscarinics within first months blockers months receiving tur overall group patients worse postoperative medicationfree survival compared non group patients confidence interval conclusion patients require higher rates continuing medication tur especially anti muscarinics months postoperatively alpha blocker months postoperatively patients also higher incidence urine retention surgery patients relatively poor treatment outcomes compared free patients
investigated degree toddlers observed emotional states toddlers temperamental traits interaction accounted variance mothers fathers parenting main effects two emotional states positive emotion negative emotion three temperamental traits negative affectivity effortful control surgency well state trait interactions examined relation parental sensitivity positive affect negative affect hypothesis toddlers temperamental traits would moderate association observed emotional states parenting partially supported significant state trait interactions found models predicting probability mothers fathers expressed negative affect toward toddlers parental sensitivity positive affect main effects temperament emotion expression accounted variance parenting elsevier inc rights reserved
pavlovian conditioned stimuli acquire incentive motivational properties phenomenon measured animals using pavlovian conditioned approach behavior drugs abuse influence expression behavior nicotine particular exhibits incentive amplifying effects conditioned approach behavior drug abuse rely overlapping corticolimbic circuitry hypothesize orbitofrontal cortex ofc regulates conditioned approach one site nicotine action ofc reduces cortical output test repeatedly exposed rats nicotine training pharmacologically inactivated lateral ofc performed vivo electrophysioloiical recordings lateral ofc neurons presence absence nicotine experiment animals trained pavlovian conditioning paradigm behavior evaluated inactivation ofc microinfusion gaba agonists baclofen muscimol experiment monitored phasic firing ofc neurons pavlovian conditioning sessions nicotine reliably enhanced conditioned responding conditioned cue inactivation ofc reduced conditioned responding especially sign tracking response ofc neurons exhibited phasic excitations cue presentation goal tracking nicotine acutely blunted phasic neuronal firing nicotine withheld conditioned responding phasic firing ofc returned level controls results suggest ofc recruited expression conditioned responses nicotine acutely influences behavior reducing phasic firing ofc elsevier ltd rights reserved
cell tracking plays crucial role biomedical computer vision areas cells generally frequent deformation activities small sizes microscope image tracking non rigid non significant cells quite difficult practice traditional visual tracking methods good performances tracking rigid significant visual objects however suitable cell tracking problem paper novel cell tracking method proposed using convolutional neural networks cnns well multi task learning mtl techniques cnns learn robust cell features mtl improves generalization performance tracking proposed cell tracking method consists particle filter motion model multi task learning observation model optimized model update strategy training procedure cell tracking divided online tracking task accompanying classification task using mtl technique observation model trained building cnn learn robust cell features tracking procedure started assigning cell position first frame microscope image sequence particle filter model applied produce set candidate bounding boxes subsequent frames trained observation model provides confidence probabilities corresponding candidates selects candidate highest probability final prediction finally optimized model update strategy proposed enable multi task observation model variation tracked cell entire tracking procedure performance robustness proposed method analyzed comparing commonly used methods experimental results demonstrate proposed method good performance cell tracking problem elsevier rights reserved
researchers different backgrounds approached topic violent video games aggression varying assumptions methods goals researchers experimental psychology orientation seek test theories controlled conditions assume children risk harm acting violence gameplay champion policies reduce youth exposure violent game content researchers applied fields public health clinical psychology criminology assume video game effects negative positive vary child circumstance content seek identify high risk patterns via studies real world settings different lenses illuminate ongoing disagreements relationship violent video games harmful aggressive behaviors disagreements could mitigated greater clarity definitions methods example confusion arises researchers fail clearly define aggression treat aggressive thoughts feelings behaviors part continuum view aggression equivalent harmful intent violence studies suggest media violence researchers like humans tend disproportionately seek value evidence supports point view actively searching common ground welcoming new researchers variety disciplines may help move field forward
due increased prevalence chronic diseases older individuals may experience deterioration health condition older ages limiting capacity social engagement turn well later life focusing care provision grandchildren older relatives informal care forms engagement paper aims identify individual characteristics may compensate health deficits enable individuals multimorbidity provide informal care use data share survey individuals aged years european countries logistic regression estimates impact different sets characteristics decision provide care presented separately people without multimorbidity adapting arber ginn resource theory expected older caregivers resources income spouse would facilitate informal care provision greater extent people multimorbidity compared without multimorbidity result confirmed care provision rates lower among individuals suffering chronic conditions factors associated caregiving part differ significantly two groups results however hint reciprocal intergenerational support patterns within families old multimorbidity likely provide care without multimorbidity also traditional gender roles women likely weakened presence health problems highlighted lack gender differences care provision among people multimorbidity
familial adenomatous polyposis fap cancer predisposition syndrome causes early onset polyposis associated increased risk hepatoblastoma currently lack consensus order apc adenomatous polyposis coli gene testing implement surveillance hepatoblastoma online questionnaire completed genetic counselors capture current practices regarding questions extracolonic findings associated fap likely prompt apc testing otherwise asymptomatic year old child negative family history multiple desmoid tumors congenital hypertrophy retinal pigment epithelium chrpe jaw osteomas hepatoblastoma hepatoblastoma screening majority recommend children less age five years known apc mutations interval every months commonly suggested however responses extended screening less annual basis results highlight need investigation genetic counselors recommend apc testing young risk children factors influence views ideal age indication apc testing studies issues would help define best clinical practice model genetic testing hepatoblastoma screening pediatric patients fap
functional electrical stimulation widely used restoration bladder functions spinal cord injury neurological disorders however neuroprostheses bladder control still imperfect due lack feedback information state controlled bladder purpose study develop implantable system allows stimulate nerves record nerve signals related condition bladder proposed stimulator consists three parts digital analog converter dac current driver switch network using current source switch network eliminates need separate current sources anodic cathodic sections reduce need interconnect lines control signals area saved power efficient configuration symmetrical regulated cascode current driver used implement high voltage compliance high output impedance improves ability load amplitude frequency pulse width stimulating current adjusted encoding dac switch sequences respectively addition also present two stage fully differential capacitively coupled amplifiers neural recording neural amplifier parameters carefully chosen according characteristics neural signal meanwhile analyzed theoretically main noise sources especially pseudo resistor feedback path gives little attention previous studies integrated neural stimulating recording frontend bladder control prosthesis designed simulated using tsmc cmos process proposed stimulator provide symmetrical cathodic first biphasic current pulse interphasic gap low headroom voltage corresponding full scale current adjustable pulse width frequency recording amplifier low input referred noise nef low power dissipation gain frequency bandwidth khz circuit analysis simulations presented examine performance proposed designs
paper presents network security laboratory project teaching network traffic anomaly detection methods electrical engineering students project design follows research oriented teaching principle enabling students make discoveries real network traffic using data captured large darkspace monitor operated university california san diego ucsd although darkspace traffic include bidirectional conversations attempts initiate contains traffic related actually perpetrating variety network attacks originating millions internet addresses around world breadth coverage makes darkspace data excellent choice hands study internet attack detection techniques addition darkspace data less privacy critical network traces contains unwanted network traffic legitimate communication lab exercises presented students learn network security challenges search suspicious anomalies network traffic gain experience presenting interpreting findings acquire security specific technical skills also general knowledge statistical data analysis data mining techniques also encouraged discover new phenomena data helps ignite general interest science engineering research vienna university technology austria first implemented laboratory summer semester class students help center applied internet data analysis caida ucsd exercises darkspace data publicly available
aim study investigate economic performance waste heat recovery whr system marine diesel engine four waste heat sources exhaust gas cylinder cooling water scavenge air cooling water lubricating oil marine diesel engine first applied drive transcritical rankine cycle trc ryf rze rfa employed system working fluids effects expander inlet pressure temperature net power output thermal efficiency total cost mass flow rate available efficiency whr system analyzed levelized energy cost used evaluate economic optimizations corresponding optimal parameters whr system results show optimal levelized energy cost rfa excellent lower rze ryf respectively payback period fuel oil saving emission reduction applied assess suitability working fluids furthermore economic optimization correlations terms dimensionless optimal pressures temperature difference ratios proposed system design optimal operating conditions elsevier ltd rights reserved
objective anxiety mood disorders amd frequent mental disorders human population recently shown increasing prevalence commonly disrupt personal working lives objective aim study analyze spectrum circulating steroids order discover differences could potentially markers affective depression anxiety identify steroids could predictive component diseases methods studied steroid metabolome including analytes men depression group men anxiety group healthy controls opls multivariate regression models used statistical analysis results discrimination group controls opls method absolute group controls sensitivity specificity relatively good predictivity also found discrimination group sensitivity specificity conclusion selected circulating steroids including neuroactive neuroprotective useful tools discriminating affective diseases adult men published elsevier inc
study wear mechanisms cnt nanocomposites produced cryomilling mechanical milling cold compacting extrusion studied wear maps showed maximum amount abrasive wear region milling times observed cryomilling samples also maps show abrasive wear region cryomilling mechanical milling maximized milling time cryomilled samples milling time weight loss decreases increasing sliding speed normal loads also abrasive wear mechanism observed conditions cryomilled samples show increased resistance delamination crack initiation wear test
background heterozygous mutations thyroid hormone receptor alpha thra gene cause resistance thyroid hormone alpha rtha disease characterized variable manifestations reminiscent untreated congenital hypothyroidism raised triiodothyronine thyroxine ratio normal thyrotropin levels recently described zebrafish embryos expressing dominant negative form thraa recapitulate key features rtha zebrafish human receptors functionally interchangeable methods study expressed several human thyroid hormone receptor alpha htra variants zebrafish embryos analyzed resulting phenotypes results htra injected embryos showed variable defects including cerebral cardiac edema likely caused aberrant looping heart development anemia incomplete formation vascular network moreover htra injected embryos presented severe defects motorneurons craniofacial development thus affecting autonomous feeding swimming behaviors surprisingly expression htra mutants detectable effect thyrotropin beta thyrotropin releasing hormone transcripts indicating action limited thyroid hormone reception beta targets hypothalamic pituitary level vivo previously described vitro treatment high triiodothyronine doses efficiently revert observed defects embryos injected missense htra variants conclusion injection human thra variants zebrafish embryos causes tissue specific defects recapitulating rtha clinical biochemical manifestations described manipulation zebrafish embryos represents novel vivo model screen functional consequences thra variants rescue potential new therapeutic compounds
brief present subspace system identification framework separable denominator systems deterministic stochastic inputs roesser form advantage proposed framework based computation state matrices opposed current algorithms compute system parameter matrices markov parameters observability matrix require solving specialized toeplitz hankel systems equations computing system parameter matrices addition problem broken two simple oblique projection computations one horizontal direction one vertical direction within framework numerical algorithms subspace state space system identification nsid past output multivariable output error state space moesp canonical variate analysis cva type algorithms obtained simulation results show algorithms accurate provide new alternatives modeling identifying causal recursive separable denominator roesser models
cells critically important pathogenesis iga nephropathy igan present study aimed investigate abundance cell activating factor baff belongs tumor necrosis factor superfamily peripheral blood patients igan different forms baff peripheral blood association clinical features immunological factors analyzed mrna levels baff associated genes peripheral blood mononuclear cells pbmcs patients igan controls analyzed quantitative polymerase chain reaction cellular baff proteins pbmcs plasma soluble baff proteins measured western blot analysis elisa respectively pbmcs patients stimulated streptococcus pyogenes pyogenes exvivo baff secretion assay data demonstrated although mrna levels baff pbmc significantly increased patients igan positively associated proliferation inducing ligand april toll like receptor tlr tlr tlr cellular baff protein pbmcs upregulated plasma baff protein levels patients igan significantly decreased compared controls however plasma baff levels positively associated serum creatinine proteinuria uric acid group streptococcus infection index patients igan patients igan plasma baff concentrations markedly higher severe renal tubular atrophy interstitial fibrosis global glomerulosclerosis furthermore baff production pbmcs patients igan increased following pyogenes stimulation exvivo conclusion plasma baff levels patients igan associated renal function disease activity pyogenes infection closely associated baff production patients igan
article study static stability tunisian electrical network face many current technical constraints maintain security entire system power context present study based modal analysis linearized system study allows determine optimum location power regulators pss iniected input voltage regulator avr based matrix called participation regulators method residues perform calculation parameters
background one third bahraini adult males females use types tobacco prevalence rates cigarette shisha smoking respectively tobacco cessation programs essential help smokers quit objectives study determine quit rates among male attendees quit tobacco clinics qtc bahrain describe related factors methods used cross sectional study design interview male tobacco smokers received care two qtc patients consulted clinics within year preceding study eligible included interviewed using structured pretested questionnaire containing questions tobacco smoking behavior quitting experience results overall quit forms tobacco attending qtc shisha smokers successful quitting cigarette smokers received nicotine replacement treatment along counseling sessions three visits clinics previous quit attempts months duration statistically significantly related successfully quitting types tobacco participants satisfied clinics however majority wanted longer opening hours increase working days clinic physicians referred study population qtc conclusion high tobacco quit rate among smokers seeking treatment qtc encouraging indicates clinics contributed tobacco cessation bahrain counselling sessions frequent visits qtc helped participants successfully quit tobacco
background previous study examining association hyperthymic temperament daily light exposure illuminance compared hyperthymic scores temperament evaluation memphis pisa paris san diego auto questionnaire version temps acquired residents sapporo oita japan located degrees degrees latitude found residents oita significantly higher hyperthymic scores residents sapporo moreover comparison regions rather regions may show dose response relationship hyperthymic temperament illuminance methods japan large islands hokkaido honshu shikoku kyushu sapporo hokkaido oita kyushu location recently collected temps data residents koshigaya located honshu degrees combined data koshigaya residents data residents sapporo oita results mean yearly total sunshine past years sapporo koshigaya oita multiple regression analyses revealed sunshine predicted significant variance hyperthymic temperament dose dependent manner limitations limitation present study lack consideration effects temperature hyperthymic temperament since correlations fairly small factors also work hyperthymic temperament conclusions present findings suggest higher illuminance may maintain hyperthymic temperament via light effects dose dependent manner elsevier rights reserved
vibration exists everywhere especially public railway operation system vibration acceleration key factor monitor evaluate structure health railway equipment paper kind self powered triboelectric nano vibration accelerometer teva presented low frequency spring mass vibration model built calculate vibration sensitive performance electric output teva prototype teva demonstrated characterized railway vibration simulation platform testified teva successfully harvest low frequency vibration energy convert electrical power achieve self powered vibration acceleration monitoring system output current voltage teva also sensitive vibration acceleration linearly hence used self powered nano vibration accelerator fault diagnosis addition generated electricity used charging lithium battery supplies power zigbee module experiment shows charged battery teva support wireless communication zigbee modules temperature humidity sensors embedded temperature humidity train degrees respectively therefore vibration energy harvested stored power supply wireless sensor network nodes near future
insomnia considered hyperarousal disorder several psychophysiological domains including autonomic nervous system ans activated potentially contributing increased risk cardiovascular disease aimed determine whether insomnia develops context transition menopause menopausal transition insomnia mti similarly characterized autonomic arousal also took account modulation ans hormonal changes menstrual cycle factor previously considered studies insomnia twenty one women insomnia controls also menopausal transition overnight laboratory based polysomnographic recordings including electrocardiograph follicular luteal progesterone phases menstrual cycle women recordings phases nocturnal time frequency domain heart rate variability hrv measures calculated heart rate significantly elevated similar bpm mti compared controls follicular luteal phases across hours night including undisturbed periods nrem rem sleep higher tended associated lower frequency time domain vagal hrv indices mti compared controls groups significantly higher total high frequency hrv measures lower luteal phase compared follicular phase addition rem compared nrem sleep characterized increased coupled decreased vagal modulation increased sympathovagal balance insomnia menopausal transition characterized nocturnal autonomic hyperarousal follicular luteal phases menstrual cycle could factor etiology mti well potential risk factor elsevier ltd rights reserved
hilde bruch foundation lecture milestone survey current theory treatment anorexia nervosa bruch described problems body perception emotion processing interpersonal relationships core theoretical aspects illness built theory psychopathology aspects well animal studies attachment also noted many psychological problems result consequence starvation first part paper parse bruch clinical descriptions elements psychopathology disturbances body perception attachment emotion expression perception regulation social comparison interpersonal family therapeutic relationships order assemble update theoretical evidence model illness second part describe extend description three core targets treatment family relationships patient inner confusion nutritional restoration copyright john wiley sons ltd eating disorders association
purpose ketamine induced cystitis among chronic ketamine young abusers increased dramatically brought attention urologists underlying pathophysiological mechanism still unclear therefore purpose study elucidate possible pathophysiological mechanism proteomic techniques experimental design bladder tissues obtained seven patients seven patients interstitial cystitis bladder pain syndrome five control subjects underwent videourodynamic study followed augmentation enterocystoplasty increase bladder capacity based approach functional classifications network analyses used proteomic bioinformatics analyses protein validation carried western blot analysis results among proteins identified bioinformatics analyses revealed several actin binding related proteins cofilin myosin light polypeptide filamin gelsolin lamin involved apoptosis besides contractile proteins cytoskeleton proteins myosin light polypeptide filamin calponin found downregulated bladders conclusions clinical relevance increased apoptosis might mediated actinbinding proteins activated protease rapid detrusor contraction might induced contractile proteins cytoskeleton proteins
work analyses use parallel processing techniques synthetic aperture ultrasonic imaging applications particular total focussing method problem studied work presents different parallelization strategies multicore cpu gpu architectures parallelization processes platforms discussed optimized order achieve real time performance
cerebral ischemia diabetics results severe brain damage different animal models cerebral ischemia used study aggravation ischemic brain damage diabetic condition since different disease conditions diabetes differently affect outcome following cerebral ischemia stroke therapy academic industry roundtable stair guidelines recommends use diseased animals evaluating neuroprotective therapies targeted reduce cerebral ischemic damage goal review discuss technicalities pros cons various animal models cerebral ischemia currently employed study diabetes related ischemic brain damage rational use animal systems studying disease condition may better help evaluate novel therapeutic approaches diabetes related exacerbation ischemic brain damage elsevier inc rights reserved
hybrid electrical vehicles hevs becoming popular nowadays automobile market due virtues energy saving environmental friendly low noise simple mechanical structure called planetary gears widely used hevs allow internal combustion engine ice constantly working high efficiency region save energy decoupling speed ice wheel load despite advantages planetary gears also introduce several problems hev system vibration abrasion mechanical maintenance fee paper novel axial flux magnetic field modulated dual mechanical port dual electricalport mfm dmp dep machine proposed hevs applications replace whole hybrid electric powertrain hevs cooperating magnetic field modulated mfm machine conventional synchronous machine proposed machine capable decoupling speed torque ice wheel load electrically without usage mechanical speed decoupling devices hybrid system mechanical transmission loss could avoided vibration abrasion maintenance fee system could reduced based proposed machine hev system constructed operating modes illustrated firstly machine structure operation principles operation modes introduced torque transmission capability verified quasi fea four models different gear ratio established determine influence gear ratio variation optimization gear ratio
hyperspectral raman images human prostatic cells collected analysed several approaches reveal differences among normal tumor cell lines objective study test potential different chemometric methods providing diagnostic responses focused analysis region owing optimal signal noise ratio main differences spectra two cell lines observed frequency range multivariate analysis identified two principal components positively recognized due protein lipid fractions respectively tumor cells exhibited modified distribution cytoplasmatic lipid fraction mainly localized alongside cell boundary may result useful preliminary screening principal component analysis found provide high contrast well suited image processing purposes self modelling curve resolution made available meaningful spectra relative concentration values revealed increase lipid fraction tumor cell respect control finally univariate approach confirmed significant reproducible differences normal tumor cells elsevier rights reserved
kernel krx detector proposed kwon nasrabadi exploits kernel function obtain better detection performance however still two limits improved one hand reasonable integration spatial spectral information used improve detection accuracy hand parallel computing used reduce processing time available krx detectors accordingly paper presents novel weighted spatial spectral kernel wsskrx detector parallel implementation graphics processing units gpus wsskrx utilizes spatial neighborhood resources reconstruct testing pixels introducing spectral factor spatial window thereby effectively reducing interference background noise kernel function redesigned mapping trick krx detector implement anomaly detection addition powerful architecture based gpu technique designed accelerate wsskrx substantiate performance proposed algorithm synthetic real data conducted experiments
review represents southern ocean community satellite data needs coming decade developed widespread engagement incorporating perspectives range stakeholders research operational designed important community driven strategy paper provides rationale information required future planning investment southern ocean vast globally connected communities require satellite derived data region diverse review includes many observable variables including sea ice properties sea surface temperature sea surface height atmospheric parameters marine biology micro macro related activities terrestrial cryospheric connections sea surface salinity discussion coincident situ data collection recommendations include commitment data continuity increases particular capabilities sensor types spatial temporal improvements dissemination data products uncertainties innovation calibration validation capabilities full recommendations detailed variable well summarized review provides starting point scientists understand southern ocean processes global roles funders understand desires community commercial operators safely conduct activities southern ocean space agencies gain greater impact southern ocean related acquisitions missions
article presents account effectiveness implementing eco initiatives recycle water food waste selected cape town hotels well whether initiatives would successful future endeavour pursue suggests corporate travel policies demand travellers seek environmentally friendly hotels research strategy gathers facts relevant theory article therefore employs multi strategy research approach effective corroborate findings quantitative qualitative data case studies questionnaires interviews utilised article shows earthworm farms convert organic food waste usable compost reduces production waste rainwater harvesting stores captured rainwater future use serves alternative source surface water findings show positive response hotel staff towards implementing initiatives suggests would successful future endeavour elsevier ltd rights reserved
study explore blood material interactions hemodynamics impacted rendering clinical quality jude medical bileaflet mechanical heart valve bmhv superhydrophobic aim reducing thrombo embolic complications associated bmhvs basic cell adhesion evaluated assess blood material interactions hemodynamic performance analyzed without coating results show coating receding contact angle degrees strikingly eliminates platelet leukocyte adhesion surface alternatively many platelets attach activate pyrolytic carbon receding base material bmhvs show performance index increases coated valve relative uncoated valve maximum possible improved performance valves exhibit instantaneous shear stress reynolds shear stress therefore bmhv potential relax requirement antiplatelet anticoagulant drug regimens typically required patients receiving mhvs minimizing blood material interactions minimal impact hemodynamics show first time coated surfaces may promising direction minimize thrombotic complications complex devices heart valves
rainwater harvesting consisting collecting runoff precipitation widely developed stop groundwater declines even raise water tables however expected environmental effect self evident show simple setting success conjunctive use depends whether runoff rate threshold value moreover bigger storage capacity higher runoff rate must obtain environmentally efficient system also extend model include hydrological parameters ecological damages respectively increase decrease environmental efficiency rainwater harvesting
victims violence need special treatment emergency room including exact documentation stand court may happen documentation must made clinician forensic pathologist site aim review provide clinicians guide documenting information victims violence identify potential victims violence presentation selected typical cases discussion basic literature expert opinions victims violence present variety injury patterns attending physician must recognize result violence urgent care needed forensic pathologist available documentation must made clinician particular importance attached exact photo documentation description injuries commonly physicians nurses adequately trained dealing medicolegal situations continuing education field wound documentation words pictures necessary order provide proper documentation cooperation clinicians forensic medicine specialists intensified
vibration energy harvesting converts mechanical energy ambient sources electricity power remote sensors compared linear resonators poor performance away natural frequency nonlinear vibration energy harvesters perform better use vibration energy broader spectrum present hybrid nonlinear energy harvester combines stability internal resonance increase frequency bandwidth two fold increase frequency bandwidth obtained compared stable system fixed magnets harvester consists piezoelectric cantilever beam carrying movable magnet facing fixed magnet spring allows magnet move along beam provides extra stored energy increase amplitude vibration acting mechanical amplifier electromechanically coupled mathematical model system presented obtain dynamic response cantilever beam movable magnet output voltage perturbation method multiple scales applied solve equations obtain approximate analytical solutions effects various system parameters frequency responses investigated numerical approaches long time integration runge kutta method shooting technique used verify analytical results results study used improve efficiency converting wasted mechanical vibration useful electrical energy broadening frequency bandwidth elsevier ltd rights reserved
surface remote sensing aerosol properties provides ground truth satellite model validation important component aerosol observation system due different characteristics background aerosol variability information obtained different locations usually different spatial representativeness implying location carefully chosen measurement could extended greater area study present objective observation array design technique automatically determines optimal locations highest spatial representativeness based ensemble kalman filter enkf theory ensemble constructed using aerosol optical depth aod products five satellite sensors optimal locations solved sequentially minimizing total analysis error variance means observations locations reduce background error variance largest extent location determined algorithm verified larger spatial representativeness arbitrary location addition existing active aerosol robotic network aeronet sites selected optimal locations mostly concentrated regions high aod inhomogeneity spatial representativeness namely sahel south africa east asia north pacific islands places focuses establishing future aeronet sites order reduce uncertainty monthly mean aod observations locations contribute approximately total background uncertainty reduction
background children disabilities often target prejudice peers effects prejudice include harmful health consequences contact hypothesis previously shown promote positive attitudes towards range social groups objective conduct systematic review meta analysis effectiveness school based interventions improving children attitudes towards disability contact people disabilities methods comprehensive search conducted across multiple databases studies included evaluated intervention aimed improve children attitudes towards disability involved either direct person indirect extended contact people disabilities data synthesised meta analysis results twelve studies met inclusion criteria found significant effects six used direct contact two used extended contact two used parasocial media based contact one used guided imagined contact one parasocial contact intervention found significant effects three meta analyses showed direct contact extended contact improved children attitudes evidence parasocial contact conclusions direct extended guided imagined contact interventions effective improving children attitudes towards disability evidence parasocial contact elsevier inc rights reserved
surface layers high water content low bearing capacity far soft clay foundation come reclaimed land project reclamation difficult improve soft clay foundation traditional vacuum preloading new method named surface soft soil improvement presented paper make soft clay foundation improved preliminary forming hard coat layer foundation may reach needs construction construction technology horizontal filter pipe net used instead sand bedding course laying woven cloth non woven geotextile surface reclaimed silt installing pvds manpower becomes possible besides vertical pvds connected horizontal filter pipe net directly makes whole spatial drainage system loss degree vacuum decreased improvement increased thus construction technology reference large scale engineering construction similar projects
study design resident case problem background although rare general population bone soft tissue tumors may frequently encountered patients seeking physical therapy propensity initial symptoms mimic commonly treated musculoskeletal disorders screening tumors requires physical therapist attentive unexpected findings purpose paper describe clinical reasoning screening processes physical therapists facilitated timely recognition bone soft tissue tumors patients referred medical channels diagnosis referral diagnoses lumbar spinal stenosis calcaneal bursitis postexcisional quadriceps weakness comprehensively examined patients either atypical examination findings failed respond physical therapy treatment physical therapists alerted appropriate medical providers examination findings diagnoses high grade osteosarcoma pelvis chondroma knee liposarcoma thigh followed discussion tumors lower extremity initially mimic common musculoskeletal pathology physical therapists must remain alert red flags atypical signs symptoms poor responses treatment even patients referred medical channels particular attention necessary case unusual symptoms lower extremity half primary malignant tumors occur
findings extensive literature survey focusing bridge structural health monitoring shm deployments presented conventional maturing emerging technologies reviewed well deployment considerations new shm endeavors lack published calibration studies quantification uncertainty studies new sensors highlighted major concern area future research currently examples shm systems clearly provided significant value owners monitored structures results literature survey used propose categorization system better assess potential outcomes bridge shm deployments shown shm studies categorized one combination following anomaly detection sensor deployment studies model validation threshold check damage detection new framework aids engineers specifying monitoring systems determine measured hence allowing better evaluate value may delivered relevant stakeholders monitoring investments
older populations improved ready made meal packaging may potentially contribute adequate nutritional intakes turn facilitate maintenance independent living consequently deeper understanding features ready made meal packages important older people step towards goal features ready made meal packaging appreciated current aged years future aged years seniors studied internet survey finland netherlands minor significant differences found two senior groups four packaging features valued finnish dutch consumers easy readability easy disposability recyclability visibility contents easy opening features basically regardless age group gender country older people show interest either multi packages eating meals directly package future senior men frequently using ready made meals identified promising target segment development marketing novel readymade meals generally special attention paid package design age relevant features easy opening easy read information impact culture specific translation features packaging design elsevier ltd rights reserved
skin outermost part body thus inevitably exposed rays environmental pollutants oxidative stress hazardous factors accelerates skin aging induces skin inflammation carcinogenesis aryl hydrocarbon receptors ahrs chemical sensors abundantly expressed epidermal keratinocytes mediate production reactive oxygen species neutralize minimize oxidative stress keratinocytes also express nuclear factor erythroid related factor nrf master switch antioxidant signaling notably fine tuned crosstalk ahr nrf mutually increase decrease activation states many nrf mediated antioxidant phytochemicals capable downmodulating ahr signaling precise mechanisms phytochemicals differentially affect ahr nrf system remain largely unknown warrant future investigation
background recent studies shown longer increased risk suicide patients affected multiple sclerosis objectives describe suicide cases within large french cohort assess whether patients higher risk suicide compared general population methods data derives study long term mortality prevalent cases specialist centres deceased patients january suicides results mean time clinical onset death years standard deviation years none within first years significantly shorter patients died causes mean age death also lower standardized mortality rates around several sensitivity analyses reflecting excess mortality compared general population conclusion findings indicate excess suicide risk may longer true patients highlight changing profile cases occurring later disease course studies population based registries needed confirm explain potential changes treatments impact
report use one dimensional photonic crystals detect clinically relevant concentrations erbb neu cell lysates erbb pivotal breast cancer biomarker targetable oncogenic driver associated aggressive breast cancer subtypes quantitate soluble erbb developed optical platform combines label free fluorescence detection modes platform makes use sandwich assay one dimensional photonic crystals sustaining bloch surface waves tailored monoclonal antibody highly specific biological recognition bsw biochip second step second antibody erbb quantitatively detects bound analyte strategy present approach takes advantage combination label free fluorescence techniques making bio recognition robust sensitive fluorescence operation mode platform attain limit detection erbb cell lysates resolution meets international guidelines recommendations diagnostic erbb assays future may help precisely assign therapies counteracting cancer cell proliferation metastatic spread
wban wireless body area network growing technology preferred medical science wban sensors used monitor postures person posture playing crucial role person life provide significant amount important information nonverbal communication emotional cues recent trend research ban sensors used identify different postures person correctly classify health condition postures could potentially provide valuable clues person health class interaction poses new challenge classifying static dynamic postures triaxial accelerometer required find tilt person respect line passing centre gravity based tilt posture classified paper aims uniquely distinguishing static dynamic postures fall also detected time detailed deployment scenario system architecture suitable algorithm presented illustrate working proposed system
objective gastrointestinal symptoms common cirrhosis impact quality life pathophysiology relation energy intake fully elucidated effect liver transplantation symptoms studied aimed prospectively evaluate symptoms determinants transplantation potential relation energy intake cirrhosis methods total cirrhotic liver transplant candidates completed gastrointestinal symptom rating scale gsrs hospital anxiety depression scale fasting serum glucose insulin measured patients serum thyrotropin free cortisol free testosterone estradiol dehydroepiandrosterone sulfate interleukin tumor necrosis factor alpha measured subgroup patients transplant recipients followed year separate cohort cirrhotic patients underwent high caloric satiation drinking test sdt results symptoms severe cirrhotics compared controls general population regression analysis total gsrs score independently related lactulose anxiety low free testosterone four six gsrs domain scores improved significantly year post transplant total gsrs score remained higher compared controls symptoms predicted ingestion fewer calories sdt compared patients controls conclusions psychological distress lactulose treatment low testosterone predictors symptoms common among cirrhotic transplant candidates also associated decreased energy intake measured sdt symptoms remain concern post transplant
assessments linguistic ability amongst inner city african american children cross cultural assessments problem solving skills amongst participants without formal education several contexts around world demonstrated need investigators distinguish possible existence form competency matter whether evidence competency elicited particular assessment tool previously mentioned cases evidence suggests participants competencies question failed demonstrate least partially result nature assessment context current article takes demonstrations need culturally sensitive assessment point departure argues today development competence understood necessary benefits idea culturally sensitive assessment still relies problematic characterization competencies discrete sets stable underlying dispositions current research dynamic systems perspective psychology suggests intelligent human action involves contextual self organized emergence adaptive behavioral solutions rather expression preplanned latent competencies adequate conceptualization competence must therefore account emergence rather positing competencies hidden latent behavioral performances
study presents new performance analysis criterion called effective ecological power density efecpod application joule brayton cycle jbc turbine effective efficiency effective power cycle temperature ratio turbine volume considered together performance stated unique value developed criterion emissions formation turbine dimensions considered cycle temperature ratio turbine volume respectively turbine volume also related production cost heat engine therefore proposed criterion essential multipurpose optimization furthermore criterion developed applied gas cycles heat engines also performance investigation jbc gas turbine terms effective power density epd carried using new finite time thermodynamics modeling fitm influences engine design parameters cycle temperature ratio cycle pressure ratio turbine speed intake temperature intake pressure equivalence ratio epd efecpod examined results presented essential tool jbc turbine designers elsevier ltd rights reserved
despite growing demand brazilian companies well qualified professionals information technology brazilian educational system able meet demand satisfactory way especially quality vocational training question one way address training problem creation specialized postgraduate courses area focused students already graduated working market facilitate access course working students opted offering distance learning model web based platform hence paper describes structure experiments conducted three offers course sought resolve measure various problems associated distance learning sizing scalability teachers tutors relation number students another problem tackled student isolation dealt proactive attitudes motivating actions tutors teachers tools chat forums faq mails problem student authentication overcome person periodical evaluations plus continuous monitoring monograph thesis development supervising teacher final oral defense thesis
purpose although previous research established moral emotion moral judgment moral identity influence consumer intention engage prosocial behavior donating volunteering circumstances factors reality concurrently influence judgment process therefore important get nuanced understanding combinations factor lead high intention engage prosocial behavior paper aims discuss issues design methodology approach research employs fuzzy set qualitative comparative analysis explore different configurations moral emotion judgment identity lead high consumer intention engage prosocial behavior findings findings indicate four configurations moral emotion moral judgment moral identity lead high intention engage prosocial behavior research limitations implications research focuses case hospital indonesia thus important overgeneralize findings nonetheless methodological standpoint opportunity emerges broaden examinations service cultural contexts practical implications findings research help hospital develop effective combinations advertising marketing strategies promote prosocial behavior among customers originality value paper provides first empirical evidence existence multiple pathways moral emotion judgment identity lead high consumer intention engage prosocial behavior implications research also highlight importance cultural context understanding consumer behavior
contribution investigates social distance immigrants poland four western european cities london birmingham berlin munich particularly polish immigrants distance towards members ethnic religious sexual minorities various social roles presenting unique data first wave longitudinal qualitative study first discuss differential levels social distance polish immigrants place members minority groups city find respondents socio demographic characteristics impact social distance education occupation may less effect place origin poland current place residence work moreover factors work differentially across four cities analysing social distance respect three dimensions difference ethnicity religion sexuality find several different social distancing mechanisms ultimately argue social science needs consider regional local contexts social attitudes towards minorities acquired exercised similarly need reflect group presumed homogeneity unifying visions host society site migrants incorporation
frequent emergency department use public health policy relevant concern previously examined medicare population conducted retrospective claims based analysis nationally representative sample fee service medicare beneficiaries examine frequent use used multinomial logistic regression study relationship frequent use sociodemographic outpatient care clinical characteristics factors strongly associated frequent use included age years compared years relative risk ratio confidence interval mental illness relative risk ratio low versus high continuity care associated greater risk frequent compared non use although clinical demographic characteristics strongly associated frequent use poor continuity care also contributor
substantial research shows early adversity including child abuse neglect associated diminished health across life course across generations less well understood relationship early adversity adult socioeconomic status including education employment income collectively outcomes provide indication overall life opportunity analyzed data states district columbia used adverse childhood experiences ace module behavioral risk factor surveillance system examine association aces adult education employment income compared participants aces higher ace scores likely report high school non completion unemployment living household federal poverty level evidence suggests preventing early adversity may impact health life opportunities reverberate across generations current efforts prevent early adversity might successful broaden public professional understanding narrative links early adversity poverty discuss findings within context structural policies processes may contribute intergenerational continuity child abuse neglect poverty authors published elsevier ltd
novel dynamic radio cooperation strategy proposed cloud radio access network cloud ran consisting multiple remote radio heads connected central virtual base station vbs pool particular key capabilities cloud ran computing resource sharing real time communication among vbss leveraged design joint dynamic radio clustering cooperative beamforming scheme maximizes downlink weighted sum rate system utility wsrsu due combinatorial nature radio clustering process non convexity cooperative beamforming design underlying optimization problem hard extremely difficult solve large network proposed approach aims suboptimal solution transforming original problem mixed integer second order cone program socp applying sequential convex approximation sca derive novel iterative algorithm numerical simulation results show low complexity algorithm provides near optimal performance terms wsrsu significantly outperforming conventional radio clustering beamforming schemes additionally results also demonstrate significant improvement computing resource utilization cloud ran traditional ran distributed computing resources
many researches emphasized importance quality control manufacturing engineering little researches civil engineering field paper pointed possible apply process control method construction quality monitoring based information theory possible build supervision model restrain opportunism agents paper shed light possible application framework process quality control civil engineering
paper assesses different levels geographical disaggregation wind photovoltaic energy resources could affect outcomes energy system model energy system models used policy making typically high technology detail little spatial detail however generation potential integration costs variable renewable energy sources time profile production depend geographic characteristics infrastructure place case study austria generate spatially highly resolved synthetic time series potential production locations wind power regional differences costs wind turbines however smaller cost reductions induced technological learning one modelled decade wind availability shows significant regional differences mainly differences summer days winter nights important solar availability installations homogenous introduce wind data energy system model jrc times different levels regional disaggregation results show point maximum potential reached disaggregating wind regions significantly affects results causing lower electricity generation wind authors published elsevier ltd
conflicting evidence regarding long term effects unilateral nephrectomy cardiovascular diseases excessive increase blood pressure exercise called hypertensive response exercise may sign unborn hypertension increased cardiovascular risk decrease glomerular filtration rate gfr patients unilateral nephrectomy may associated disturbance circadian changes without affecting absolute levels aimed investigate circadian changes hypertensive response exercise normotensive patients preserved renal functions undergone unilateral nephrectomy causes rather organ donation study enrolled patients mean age years male unilateral nephrectomy healthy controls mean age years male patients undergone office ambulatory measurements treadmill stress test median time since nephrectomy years patient group median gfr patient group lower controls without significance respectively significant difference groups terms office measurements night time diastolic systolic mean arterial pressure map night day time ratio map ambulatory measurements results treadmill stress tests hypertensive response exercise ratios also similar groups study revealed increase long term cardiovascular risks one decade unilateral nephrectomy based circadian changes hypertensive response exercise normotensive patients
immigration raids exemplify reach immigration law enforcement lives latino community members yet little research characterizes health effects raids examined health implications immigration raid resulted multiple arrests deportations occurred midway community survey latino population used linear regression following principal axis factoring examine influence raid timing immigration enforcement stress self rated health controlled age sex relationship status years county raid occurred children home nativity participants completed survey raid completing survey raid associated higher levels immigration enforcement stress lower self rated health scores findings indicate negative impact immigration raids latino communities immigration discussions include holistic assessments health
antisliding safety middle saddle key issue design three pylon suspension bridges vehicle load main adverse effect especially unsymmetrical vehicle load general mechanical model saddle sliding behavior reviewed proposed characteristics load responses main cable investigated explore simplified live load computational method based deterministic approach codes reliability based approach antisliding safety middle saddle discussed assessed taizhou yangtze river bridge two symmetrical spans study shows geometric nonlinearity caused dead load big effect load responses main cable must included design maximum difference geometrically linear nonlinear cases due live load whereas conditions balanced static friction coefficient smaller without consideration geometric nonlinearity caused live load means assessment antisliding safety saddles conservative live load geometric nonlinearity included linear superposition principle traffic load influence surface directly applied results based deterministic approach codes indicate antisliding safety factor middle saddle larger ensures sliding middle saddle main cable however results different codes differ different requirements parameters therefore based reliability approach probabilistic model saddle balanced static friction coefficient developed includes effect traffic using weigh motion wim data random synthetic vehicle flow simulation paper maximum static friction coefficient model obtained experimental data cables antisliding safety assessment saddle made different traffic conditions antisliding reliability indices larger indicating saddle good antisliding behavior reserve american society civil engineers
paper develops internet things data highway embracing end sensors sensor nodes databases big data processors web connections high end statistics engines aiming automatic pseudo real time integrative sensor stream processing fully benefitting capability sophisticated statistics packages supporting variety artificial intelligence data mining libraries specifically raspberry nodes capture signals attached sensors via gpio interfaces insert remote mysql database table using connector utility linux machine table entry purged fixed time dumped text file later batch analysis using hadoop package running windows periodically downloads sensor stream database table via implementation library extension invoking relevant operating systems calls space even spatial analysis visualization provided comprehensively
background bipolar disorder costs english economy estimated billion pound year largely incomplete recovery analysis estimated cost effectiveness group psychoeducation ped versus group peer support treating methods week pragmatic randomised controlled trial rct conducted nhs primary care primary analysis compared ped using multiple imputed datasets missing values economic model used compare ped treatment usual tau perspective health personal social services results participants receiving ped used costly health related resources net cost per person pound pound quality adjusted life year qaly gain cost per qaly gained ped may cost effective versus decision makers willing pay least pound per qaly gained ped costs avoid one relapse economic model indicates ped may cost effective versus tau reduces probability relapse reduces probability increases time relapse limitations participants generally inconsistent attending treatment sessions low numbers complete cost qaly data factors contributing pervasive uncertainty results discussed conclusions first economic evaluation ped versus pragmatic trial ped associated modest improvement health status higher costs high level uncertainty data results
body evidence implicated dietary deficiency omega polyunsaturated fatty acids pufa including eicosapentaenoic acid epa docosahexaenoic acid dha pathophysiology etiology recurrent mood disorders including major depressive disorder mdd bipolar disorder cross national cross sectional evidence suggests greater habitual intake pufa associated reduced risk developing mood symptoms meta analyses provide strong evidence patients mood disorders exhibit low blood pufa levels associated increased risk initial development mood symptoms response inflammation etiology pufa deficit may multifactorial pufa supplementation sufficient correct deficit may also antidepressant effects rodent studies suggest pufa deficiency perinatal development recapitulate key neuropathological neurochemical behavioral features associated mood disorders clinical neuroimaging studies suggest low pufa biostatus associated abnormalities cortical structure function also observed mood disorders collectively findings implicate dietary pufa insufficiency particularly development pathophysiology mood dysregulation support implementation routine screening treatment pufa deficiency patients mood disorders elsevier ltd rights reserved
brazilian public software portal spb provides social scientific service software repository given importance service improvement opportunities observed proposals assess quality software residing portal since quality control auditing submissions software aim paper present existing performance issues spb software analyzing performance anti patterns leading process collection analysis proposed process result empirical study based analysis data provided specialized performance measurement tools aims contribute enrich knowledge related performance stored systems spb
impact incontilase procedure lower urinary tract symptoms luts remains unclear aim evaluate effects incontilase procedure urodynamic stress incontinence usi consecutive women usi prospectively underwent incontilase procedure urodynamic studies pad testing luts sexual function questionnaires assessed treatment thirty five women underwent incontilase procedure among women baseline pad weights objectively cured improved among women mild usi baseline pad weight nine cured five improved among ten women baseline pad weight two cured six improved among women complete questionnaire data months seven subjectively cured four improved regarding luts majority domains king health questionnaire female sexual desire function exhibited significant improvements forty percent partners patients felt sexual function improved months nonetheless urodynamic values differ across timeline effect incontilase procedure mild usi moderate month follow effective pad weight moreover improved luts quality life qol sexual function partners studies performed assess long term sustained efficacy
human osteoarthritic chondrocytes hoacs characterized dedifferentiated catabolic phenotype lack ability restoring inherent functions investigated whether extrinsically supplemented mechanical signal via compression loading would affect phenotype hoacs specifically applied cyclic compression loading cultured hoacs collagen constructs measured expression major chondrogenic factors cell matrix interaction molecules matrix degradation enzymes dynamic compression loading stimulates expression nuclear localization sox hoacs reduces catabolic events via downregulated expression collagenases results contribute better understanding towards mechanoregulation hoacs elsevier inc rights reserved
one common aspect traditional software development managing requirements requirements emerge throughout software development process thus needed addressed proper communication integration stakeholders developers documentation agile methodology innovative iterative process supports changing requirements helps addressing changes throughout development process requirements elicited beginning every software development process project product latter prioritized according importance market product one important influencing steps making software product requirements prioritization prioritizing requirements helps software team understand existence importance particular requirement importance use urgency time market many requirements prioritization techniques relative strength weaknesses otherwise many fail take account factors must considered prioritizing requirements cost value risk time market number requirements effect non functional requirements functional requirements several requirements prioritization methodologies aid decision making importantly many lacks account important factors significant influence prioritizing requirements requirement prioritization methodology based several factors time market cost risk etc proposed proposed model expected overcome lack sprints requirements prioritized basis influencing factors cost value risk time market etc effect non functional requirements functional requirements improve overall quality software product included development process scrum requirements prioritized based sprints human decision critically analyzing factors sub characteristics cause product success fail repeatedly thus ensuring consistency right requirements hence right prioritized requirements selected particular sprint time
background secretoglobin family member scgba plays important role secreting lung surfactant protein downstream target thyroid transcription factor material methods investigated whether single nucleotide polymorphisms snps scgba gene contribute susceptibility asthma explore possible association promoter snps missense snp stop codon tested scgba gene asthma patients healthy control subjects snpstats used obtain odds ratio confidence intervals value adjusted age sex covariables logistic regression method model dominant recessive log additive applied analyze genetic data results snp showed monomorphic genotype two promoter snps showed significant association asthma dominant model log additive model dominant model recessive model log additive model conclusions results suggest promoter snps scgba gene may contribute susceptibility asthma korean population
considering transmission capabilities renewable integration zonal regulation spinning reserve requirements discussed handle uncertainty load renewable energy well outage new zonal reserve model proposed paper including reserve dispatched time constraints zonal reserve requirements network security constraints using method chance constrained programming analysis ieee system demonstrates model schedule zonal energy regulation spinning reserve economic way renewable power integrated system authors published elsevier ltd
background cocaine addiction characterized patterns compulsive drug taking including preoccupation obtaining cocaine loss control drug intake lateral hypothalamic hypocretin orexin hcrt system implicated drug taking reinstatement drug seeking evidence suggests hcrt may drive drug seeking activation specific brain regions implicated stress system dysfunction including central amygdala cea role hcrt persistence compulsive like cocaine taking yet fully elucidated methods systemic intra cea microinfusions hcrt receptor antagonist administered rats allowed either short hour sha long hours lga access cocaine self administration animals tested fixed progressive ratio responding cocaine stress induced reinstatement drug seeking addition using electrophysiological techniques vitro slices investigated gamma aminobutyric acidergic gabaergic neurotransmission medial cea sensitivity gabaergic synapses modulation hcrt system sha lga rats results found systemic administration dose dependently decreased cocaine intake specifically lga rats sha rats microinjections nmol bilaterally cea significantly reduced cocaine intake lga rats also observed significant attenuation yohimbine induced reinstatement cocaine seeking intra cea nmol administration finally electrophysiological data indicated enhanced gabaergic neurotransmission within medial cea lga rats blocked mol conclusions findings suggest hcrt neurotransmission within cea implicated compulsive like cocaine seeking
discretely fractured reservoirs found enhanced engineered geothermal systems egs knowledge fracture network important understanding thermal hydraulics fluid flows resulting temporal evolution subsurface temperature purpose study develop analytical model fluid flow heat transport discretely fractured network used wide range modeling applications serve alternative analysis tool computationally intensive numerical codes given connectivity structure fracture network flow system solved using linear system algebraic equations pressure nodes network flow determined temperature fracture solved coupling convective heat transport fracture one dimensional heat conduction perpendicular fracture employing green function derived solution single discrete fracture predicted temperatures along fracture surfaces analytical solution compared numerical simulations using tough reservoir code two case studies showed capabilities analytical model explored effect uncertainty fracture apertures network structure thermal performance sources uncertainty independently produce large variations production temperature uncertainty network structure whenever present predominant influence thermal performance
summary majority patients receive anti osteoporotic treatment following major osteoporotic fracture despite guidelines availability effective anti osteoporotic treatments fight factors limiting diagnosis treatment osteoporosis become priority improve secondary prevention initial osteoporotic fracture purpose despite availability effective anti osteoporotic treatments osteoporosis management currently insufficient main objective study assess prevalence anti osteoporotic treatments introduced initial prior major osteoporotic fracture hospitalization recurring fractures methods conducted observational cross sectional bicentric study included patients aged years hospitalized seen consultation major osteoporotic fracture results one hundred twenty eight two hundred four patients past history major osteoporotic fracture therefore indication treatment based guidelines among patients received anti osteoporotic treatment secondary prevention initial fracture main causes non prescription identified attending physicians ignorance indication treatment ignorance fracture comorbidities failure introduce treatment associated presence comorbidities charlson comorbidity index dementia past history proximal femur fracture conclusions two thirds patients past history major osteoporotic fracture presenting new fracture treated main reason lack treatment seems stem incorrect assessment patient fracture risk although major osteoporotic fracture leads increased risk mortality requires treatment significance patient comorbidities independent risk factor leading non treatment
iron essential nutrient acting catalyst metabolic reactions fundamental cell survival proliferation iron complexed transferrin delivered metabolism endocytosis via surface receptor found transformed cells murine pten deficient cell lymphoma model cell acute lymphoblastic leukemia lymphoma cell lines overexpress consequence cells developed addiction toward iron whose chelation deferoxamine dfo dramatically affected survival induce apoptosis interestingly dfo displayed synergistic activity three specific drugs dexamethasone doxorubicin asparaginase dfo appeared act reactive oxygen species dependent dna damage response potentiated action inhibitor parp pathway dna repair results demonstrate targeting iron metabolism could interesting adjuvant therapy acute lymphoblastic leukemia
development selective sensitive analytical methods ammonium detection important evaluation environmental effects water pollution understanding nitrogen cycling ecosystems current study new nanoparticle microelectrode high selectivity sensitivity accuracy anti interference capacity successfully prepared quantitative measurement ammonia concentration artificial real wastewater samples prepared nanoparticle microelectrode selectively electrochemical catalytic oxidation activity ammonium ammonium oxidation peak current presented linear correlation ammonium concentrations artificial real wastewater samples ammonium response initial value measurements indicating prepared microelectrode reliable stable ammonium sensor lifetime modified microelectrode least days room temperature least repetitive measurements present method simple way preparing ammonium sensor good reproducibility moreover proposed electrochemical method validated comparing obtained results analysis ammonium artificial real wastewater samples obtained spectrophotometry
investigated cardio autonomic psychological effects colored light cycling wavelength ultradian rhythms two consecutive experiments explorative longitudinal test followed randomized crossover design healthy subjects exposed oscillating red green blue light heart rate heart rate variability hrv subjective wellbeing measured significant effects oscillating color light exposure observed heart rate cardio autonomic control rhythms derived hrv effects hrv replicated second experiment comparison similar white light exposure protocol vigilance showed improvement two weeks longitudinal study external color light cycling wavelength blood pressure oscillations appears amplify endogenous autonomic oscillations leads optimization cardio autonomic control effect reflected shortly onset light exposure sessions increase heart rate variability results conclude takes repeated light exposure session foster positive effects psychological aspects observed increase subjectively perceived mood longitudinal study crossover design study results study imply possible health effects color light exposure adjusted min oscillations humans ultradian rhythms novel results show possible applications oscillating visual inputs activation processes connected physiological regulation elsevier inc rights reserved
aeroelastic behavior suspension bridges generic temporal space wind distributions studied employing parametric one dimensional structural model coupled strip based indicial representation unsteady aerodynamic loads aeroelastic response spatially nonuniform gusts also investigated equations motion linearized prestressed aerostatic equilibrium expressed terms incremental kinematic variables aerodynamic loading characteristics deck cross sections runyang suspension bridge yangtze river china evaluated means computational fluid dynamics simulations performed extract aeroelastic derivatives indicial aerodynamic representation obtained aeroelastic equations motion reduced state space ordinary differential form using faedo galerkin approach reduced order bridge dynamics description aerodynamic loading via added aerodynamic states solved simultaneously using time integration numerical scheme dependence flutter condition transient response gusts shown systematic parametric studies elsevier ltd rights reserved
several lines evidence suggest pituitary adenylate cyclase activating polypeptide pacap neuropeptide playing important role neuromodulator indicated pacap associated mental diseases regulation pacapergic signals could potential target treatment psychiatric states schizophrenia recent studies suggested action neuroleptic drugs mediated dopaminergic serotonergic neurotransmission also via neuropeptides may act neurotransmitters neuromodulators present study examines whether currently used neuroleptics influence action pacap receptors whose expression altered schizophrenic patient real time polymerase chain reaction pcr used examine effects haloperidol olanzapine amisulpride expression genes coding pac vpac type receptors glioblastoma cell line example vitro model glial cells pac mrna expression fell incubation haloperidol olanzapine however effect maintained haloperidol even regulated pac mrna expression dose dependent manner examined drugs decreased vpac mrna expression especially incubation haloperidol typical neuroleptic distinctly potent atypical neuroleptic drugs olanzapine amisulpride addition pacap increased pac vpac mrna expression conclusion findings suggest pacap receptors may involved mechanism typical atypical neuroleptic drugs
rainwater harvesting rwh systems increasingly used alternative source water supply however installation often financially feasible feasibility analysis investments carried traditional techniques uncertainty limitations thus objective study describe studies concerning economic feasibility rwh systems conducted thus identifying trends current studies systematic review performed literature search published articles using defined inclusion criteria relevant articles selected noted increase publications issue recent years demonstrate feasibility systems frequently calculated discounted cash flow methods several studies seek incorporate uncertainties analysis sensitivity one study uses real options analysis analyses provide recommendations future studies overview current literature
background patients referred radiofrequency catheter ablation rfca ventricular tachycardia setting structural heart disease early post procedural mortality previously investigated objectives purpose study evaluate catheter ablation scar related methods associations clinical procedural variables within days procedure tested patients structural heart disease undergoing rfca international centers results patients mean age years left ventricular ejection fraction lvef ischemic etiology occurred confidence interval total patients died hospital discharge median days procedure refractory including major procedure related complication multivariable analysis following factors found significantly associated lvef odds ratio per percent decrease chronic kidney disease presentation storm presence unmappable vts recurrent also associated increased risk subsequent death hazard ratio hazard ratio conclusions contemporary cohort patients scar related undergoing rfca occurred cases clinical procedural variables indicating poorer clinical status low lvef chronic kidney disease storm unmappable vts post procedural recurrence may predict identification features may prompt early consideration hemodynamic support care help mitigate later potential complications american college cardiology foundation
significant recent interest sensing systems smart environments number longitudinal studies area typically goal studies develop methods predict one moment time activity activities resident home engaged may turn used determining normal abnormal patterns behaviour health care setting classification algorithms conditional random field crfs typically consider sensor activations features often treated independent general hypothesis learning patterns based combinations sensors powerful single sensors alone exhaustive approach take possible combinations sensors learn classifier weights combination clearly computationally prohibitive show application signal processing information theoretic techniques learn sensor topology home learn adjacency matrix enables determine combinations sensors useful classification ahead time result achieve classification performance better exhaustive approach whilst incurring small cost terms computational resources demonstrate results several datasets showing method robust terms variations layout number residents house furthermore incorporated adjacency matrix crf learning framework shown improve performance multiple baselines
introduction dermatitis bullosa pratensis phytophotodermatitis acute phototoxic reaction caused photosensitizing substances present different kinds plants activated ultraviolet radiation exposure acute phototoxic reaction manifests erythema vesicles even blisters morphology burns objective present case report phytophotodermatitis due heracleum sosnowskyi heracleum sosnowskyi discovered described separate species botanical literature man denova case report case skin lesions coexisted erythema multiforme implemented therapy corticosteroids antihistamines topical medications successful clinical resolution post inflammatory hyperpigmentations observed conclusions appropriate diagnosis phytophototoxic reaction may constitute challenge everyday practice
tocotrienol statins suppressors mevalonate pathway supplementation tocotrienol among statin users could potentially protect osteoporosis study aimed compare effects tocotrienol lovastatin supplementation individual treatments bone dynamic histomorphometric indices bone morphogenetic protein bmp gene expression ovariectomized rats forty eight female sprague dawley rats randomized equally six groups baseline sacrificed upon receipt groups ovariectomized except sham group ovariectomized groups administered orally daily lovastatin day alone tocotrienol derived annatto bean annatto tocotrienol day alone lovastatin day annatto tocotrienol day sham ovariectomized control groups treated equal volume vehicle eight weeks treatment rats sacrificed bones harvested bone dynamic histomorphometry bmp gene expression rats supplemented annatto tocotrienol lovastatin concurrently demonstrated significantly lower single labeled surface increased double labeled surface mineralizing surface mineral apposition rate bone formation rate compared individual treatments parallel increase bmp gene expression rats receiving combined treatment combination annatto tocotrienol lovastatin exerted either additively synergistically selected bone parameters conclusion tocotrienol augment bone formation mineralization rats receiving low dose statins supplementation tocotrienol statin users potentially protect osteoporosis
model updating using measured system dynamic response wide range applications system response evaluation control health monitoring reliability risk assessment paper interested model updating linear dynamic system non classical damping based incomplete modal data including modal frequencies damping ratios partial complex mode shapes dominant modes proposed algorithm identification model based linear structural model mass stiffness matrix represented linear sum contribution corresponding mass stiffness matrices individual prescribed substructures damping matrix represented sum individual substructures case viscous damping terms mass stiffness matrices case rayleigh damping combination former quantify uncertainties plausibility model parameters bayesian approach developed new gibbs sampling based algorithm proposed allows efficient update probability distribution model parameters addition model parameters probability distribution complete mode shapes also updated convergence issues numerical issues arising case high dimensionality problem addressed solutions tackle problems proposed effectiveness efficiency proposed method illustrated numerical examples complex modes published elsevier ltd
estimate likelihood convergence human style intelligence depends understand various mental capacities revive david hume theory motivation action argue common understanding two conventionally recognized components intelligence reason emotion confused say things like reason overcome emotion make statement meaningful forced treat reason compound notion forced unhappy mixture concepts incommensurate alternative parse intelligence different way two sets capacities non affective capacities including logic calculation problem solving affective capacities including wants preferences cares along emotions thus question convergence becomes two questions one affective one non affective capacities likelihood convergence non human lineages ecologies worlds given certain assumptions convergence non affective capacities thinking species seems likely argue convergence affective capacities seems much less likely
initiatives intercultural education frequently involved promotion contact members different groups means improving intergroup relations experience northern ireland suggests however schemes often organised delivered way opportunities sustained high quality contact limited paper considers processes contact one relatively recent initiative shared education involves collaboration separate schools deliver classes catholic protestant pupils mixed groups employing qualitative methods observation interviewing capture participants experiences contact research explores influences quality frequency cross group interaction shared class findings highlighting subject pedagogy teacher approach classroom arrangement key factors study offers suggestions policy practice enhance opportunities contact relationship building mixed classes
dynamic model proposed charlette represents interesting alternative fsd balance equation predict transient growth flame kernel dynamic wrinkling model coupled algebraic flame surface density fsd model boger evaluated first time internal combustion engine configuration preliminary tests enable evidence practical difficulties applying model type complex configuration improvements proposed adapt model engine configuration final simulations performed spark ignition engine configuration using adapted dynamic model equilibrium wrinkling formulation results compared ones obtained robert configuration using ecfm les model solving fsd balance equation dynamic model proves well predict equilibrium values account cycle cycle variabilities model parameter calculated fly contrary results obtained using equilibrium formulation clearly demonstrate flame turbulence equilibrium assumption adapted configurations combustion institute published elsevier inc
purpose overt hypothyroidism affects mostly women increasing prevalence age hypothyroidism associated accelerated atherosclerotic cardiovascular diseases possibly caused higher incidence hyperlipidemia insulin resistance hypertension heart type fatty acid binding protein fabp specific cardiomyocytes sensitive marker myocardial injury purpose study examining effect hypothyroidism fabp levels carotid artery intima media thickness cimt material method measured serum fabp levels patients overt hypothyroidism age gender body mass index matched control subjects patients newly diagnosed hashimoto thyroiditis participants underwent high resolution mode ultrasonography measurement cimt results significant difference serum levels fabp patient group controls respectively cimt level significantly higher patient group control group however homeostasis model assessment insulin resistance fasting insulin levels differ two groups discussion based results study assume fabp useful marker detecting preclinical atherosclerosis patients overt hypothyroidism associated hashimoto thyroiditis however cimt might useful marker detecting early atherosclerosis
paper reliability issues stacked gate gate electrode workfunction engineered gewe silicon nanowire sinw mosfet examined wide range ambient temperatures results obtained simultaneously compared conventional sinw gewe sinw mosfei using technology computer aided design quantum simulation results indicate two temperature compensation points tcp obtained one drain current cut frequency device figure merits foms become independent temperature found gewe sinw comparison devices hence open opportunities wide range temperature applications furthermore significant improvement analog performance gwew sinw observed terms subthreshold swing device efficiency noise conductance noise figure temperature reduces also observed low temperature gewe sinw unveils highly stable linearity performance owing reduced distortions results explain improved reliability gewe sinw low temperatures gewe sinw mosfet elsevier ltd rights reserved
paper present result regarding probability distribution wavelets coefficients extends theorem presented previous work cohen design experiments statistical process control using wavelets analysis control engineering practice include biorthogonal wavelets new control chart called owave orthogonal wavelets proposed order detect mean change process statistic proposed control chart based weighted wavelets coefficients performance study shows owave control chart performs slightly better optimal version ewma control chart ifac international rderation automatic control hosting elsevier ltd rights reserved
today industrial environment common see use pipes vessels transfer mixtures materials products along however measurement amount delivered done one way isolate components first meter weigh measure volume individual component measuring procedure often stalls production rate work implements noninvasive real time monitoring system measure flow concentration velocity distributions two phase liquid gas flow system uses combination specially designed twin plane segmented electrical capacitance tomography ect sensor portable electrodes cross correlation method velocity measurement technique measured values data ect sensor manipulated reconstruct cross sectional image pipeline computer programming images cross correlated obtain velocity profile multiphase flow visualization results deliver information regarding flow regime superficial velocity concentration distribution two phase flow rate measurement system information obtained able improve process equipment design verification existing computational modeling simulation techniques technique possibility promote excellent opportunity build methods measuring velocity field multiphase flow using noninvasive technique cross correlating
attention deficit hyperactivity disorder adhd eating disorders common concerning mental health disorders empirical theoretical support association adhd eating disorders disordered eating systematic review aims summarize extant literature comorbidity adhd eating disorders across lifespan including influences sex age eating disorder diagnosis potential mediators total peer reviewed studies diagnosed adhd eating disturbances identified key research databases twenty six studies supported strong empirical association adhd eating disorders disordered eating systematic review findings suggest children adhd risk disordered eating adolescents emerging adults adults risk eating disorders disordered eating methodological considerations future research clinical implications discussed elsevier ltd rights reserved
background coronary heart disease chd important complication atherosclerosis biomarkers associate chd development potential predict chd risk determine whether genes showing altered expression hyperlipidaemia coronary heart disease chd patients compared controls could chd risk biomarkers methods control chd groups represented atherosclerosis chd development gene profiling investigated peripheral blood mononuclear cells using dna microarrays eight selected genes expressed chd groups validated real time quantitative reverse transcription pcr plasma protein determination results defensin defa defa pro platelet basic protein ppbp beta alpha hemoglobin mrna expression significantly increased chd groups compared controls plasma ppbp defensin proteins correspondingly increased conclusion ppbp defa defa could potential chd biomarkers thai hyperlipidaemia patients
tecarfarin vitamin antagonist vka reduced propensity drug interactions evaluate pharmacokinetic pharmacodynamic safety tecarfarin performed single ascending dose sad multiple ascending dose mad tecarfarin versus warfarin studies human volunteers sad tecarfarin administered subjects received placebo cohorts auc infinity exhibited linearity dose proportionality elimination ranged hours across doses mad tecarfarin administered volunteers cohorts starting dose continued subject inr reached target range dosing titrated achieved elimination ranged doses insignificant effect inr higher doses raised inrs required titration maintain steady state inr dosing inr declined promptly discontinuation comparative study subjects received tecarfarin warfarin dose titrated mean dose achieved range tecarfarin range warfarin similar inr levels concentration coagulation factors vii similar tecarfarin warfarin tecarfarin tolerated well without serious adverse events three studies
background phenotypic studies triticeae shown low temperature induced protective mechanisms developmentally regulated involve dynamic acclimation processes understanding mechanisms important breeding cold resistant wheat cultivars study combined three computational techniques analysis gene expression data spring winter wheat cultivars subjected low temperature treatments main objective construct comprehensive network cold response transcriptional events wheat identify novel cold tolerance candidate genes wheat results assigned novel cold stress related roles wheat genes uncovered novel transcription gene interactions identified genes representing known novel candidate targets associated cold tolerance wheat results also show delays terms activation repression genes across wheat cultivars play key roles phenotypic differences among winter spring wheat cultivars adaptation low temperature stress cold shock cold acclimation conclusions using three computational approaches identified novel putative cold response genes gene interactions results provide new insights complex mechanisms regulating expression cold responsive genes wheat
suites numerical models used simulating climate planet usually run dedicated high performance computing hpc resources study investigates alternative usual approach carrying climate model simulations commercially available cloud computing environment test performance reliability running cesm community earth system model flagship climate model united states developed national center atmospheric research ncar amazon web service aws cloud computing environment amazon com inc starcluster used create virtual computing cluster aws cesm simulations wall clock time one year cesm simulation aws virtual cluster comparable time spent simulation local dedicated high performance computing cluster infiniband connections cesm simulation efficiently scaled number cpu cores aws virtual cluster environment cores standard configuration cesm spatial resolution degrees latitude degrees longitude increasing number cores reduces wall clock running time scaling nearly linear beyond cores communication latency starts outweigh benefit distributed computing parallel speedup becomes nearly unchanged
concepts size scale fundamental importance science engineering technology occupy central place human experience thought size shape crucial properties physical abstract objects scale dimension basic descriptive tools employ compare understanding dependence physical phenomena size scale allows develop predictive tools form core design enable creation artefacts technological systems particular interest situations size dependence turns complex characterized changes transitions behaviour different scales laboratory full scale prototypes nano scale objects opposed macroscopic etc scaling transitions size effects fracture strength materials structures particular significance modern science engineering boundaries scale mechanical phenomena studied devices exploited expanding one hand towards global scale phenomena towards nanometre scale processes circumstances challenge conventional wisdom acquired many decades according laboratory experiments performed engineering scale sub meters provide source material property data used input modelling scale real object deviations accepted scaling laws found new physical deformation mechanisms need proposed identified new modelling approaches developed validated paper review examples non trivial size dependence address fundamental question efficient description size effects scale transitions functional description multi scaling power law regimes considered functional form suitable task identified form applied variety experimental data manifesting size effects including dual failure strength criteria stress toughness fatigue crack growth thresholds kitagawa takahashi diagram applications context fretting fatigue paris fatigue crack growth law hardness coated systems etc
paper cmos operational amplifier presented cmos operational amplifier presented operating power supply microamp input bias current micrometer technology using nonconventional mode mos transistors whose input dependent bias current unique behavior mos transistors sub threshold region allows designer work low input bias current also allows operating low voltage operating device weak inversion results low power dissipation dynamic range degraded optimum balance power dissipation dynamic range results mos transistors operated moderate inversion comparison reported low power low voltage amps micrometer technology amp low standby power consumption high driving capability operated low voltage operating device moderate version good solution also operating device sub threshold region allows lower power dissipation also lower voltage operation achieved proposed amp simple two stage single ended amp input stage amp differential amplifier nmos pair operational amplifiers opa mps commonly called one basic building blocks analogue electronic circuits operational amplifiers linear devices properties required nearly ideal amplification therefore used extensively signal conditioning filtering perform mathematical operations add subtract integration differentiation
physical inactivity reached epidemic proportions modern society abundant evidence points causal link physical inactivity increased risk numerous noncommunicable diseases types cancer heart disease well premature mortality yet despite overwhelming evidence many individuals meet recommended amount physical activity required achieve maximum health benefits primary care physicians advice highly regarded clinicians unique opportunity play important role enabling patients modify behavior point care goal guiding patients adopt maintain active lifestyle current study authors evaluate pertinent literature fields medicine public health economics psychology suggest comprehensive approach physical activity counseling primary care level first examine public health approach physical activity counseling proceed offer insights behavioral economics emerging field combines principles psychology economics application key behavioral economics tools precommitment contracts framing physical activity counseling primary care elaborated cancer clin american cancer society
background hyperekplexia rare disorder characterized excessive startle response acoustic visual stimuli inherited autosomal recessive dominant pattern objective describe clinical genetic features hyperekplexia jordanian patients methods retrospective study includes patients proved genetic diagnosis hyperekplexia presented clinic jordan university hospital january july results total children families included total follow period ranged one eleven years majority patients initially misdiagnosed epilepsy patients excessive startle response since birth tonic apneic spells occurred patients fourteen patients received clonazepam stopping clonazepam three years age failed due reappearance tonic apneic spells recurrent falling due reasons delayed motor development occurred speech delay global developmental delay autism spectrum disorder patient mode inheritance autosomal recessive families mutations glra gene present common mutation mutations glrb gene present patients slca gene patients conclusion clinical presentation hyperekplexia jordanian patients manifested tonic apneic spells homozygous patients persistence apneic spells recurrent falls throughout childhood necessitate continuous treatment surveillance japanese society child neurology published elsevier rights reserved
high penetration micro grid based renewable distributed generators electrical network brought new issues stability transient operation grid however disconnection reconnection local networks may give rise undesired transient overcurrents damage avoided order solve problem paper presents novel synchronization method grid connection synchronization method implemented grid connected power converter acts intelligent connection agent adapts magnitude frequency phase angle voltage point common coupling pcc equal main voltage despite grid frequency voltage variations system simulated using matlab software results discussed order prove performance robustness synchronization technique
context according search reported paper writing may large number papers published area software engineering since inception citations crucial research area position work build work others identification characterization highly cited papers common regularly reported various disciplines objective objective study identify papers area influenced others measured citation count studying highly cited papers helps researchers see type approaches research methods presented applied papers able learn write higher quality papers likely receive high citations method achieve objective conducted study comprised five research questions identify classify top highly cited papers terms two metrics total number citations average annual number citations results total number citations top paper metrics suite object oriented design cited times published average annual number citations top paper qos aware middleware web services composition cited times average annually published conclusion concluded important identify highly cited papers also characterize overall citation landscape field hope paper encourage discussions community towards analysis formal characterization highly cited papers elsevier rights reserved
background various studies experimentally provoked ice cream headache headache attributed ingestion inhalation cold stimulus hics using different provocation protocols aim study compare two provocation protocols methods ice cubes pressed palate fast ingestion ice water used provoke hics clinical features compared results ice water stimulus provoked hics significantly often ice cube stimulus ice water provoked hics significantly shorter latency median range median range difference pain localisation character ice cube stimulation predominantly described pressing ice water stimulation stabbing second hics followed headaches provoked ice water lacrimation occurred significantly often volunteers without hics discussion hics provoked ice water frequent shorter latency different pain character higher pain intensity hics provoked ice cubes finding two subsequent hics attacks volunteers supports notion two types hics exist lacrimation hics indicates involvement trigeminal autonomic reflex
carbon nanopipette cnp comprised pulled glass pipette terminating nanoscale tens hundreds diameter carbon pipe entire inner glass surface cnp coated carbon film providing electrically conductive path carbon tip distal macroscopic end pipette cnp double nanoelectrode enabling electrical measurements carbon lining nanoinjector facilitating reagent injection hollow bore aid lock amplifier measured real time millisecond resolution variations impedance interfacial capacitance cnp penetrated cytoplasm nucleus adherent human osteosarcoma cells microinjection capacitance change associated nucleus penetration average times greater one associated cell membrane penetration experimental data compared favorably agreed theoretical predictions based simple electrical network model proof concept cytoplasm nucleus transfected fluorescent trna enabling real time monitoring trna trafficking across nuclear membrane cnp provides robust reliable means detect cell nucleus penetration trigger injection thereby enabling automation cell injection
aimto identify core antecedents job stress job satisfaction explore potential stress interventions improve job satisfaction backgrounddecreased job satisfaction nurses strongly associated increased job stress stress management strategies might potential improve job satisfaction evaluationcomparative scoping review studies location outcomes within job demands job resources model stress identify commonalities trends discussionmany antecedents phenomena appeared consistently suggesting common mediators others variable appearance emotional demands common antecedent later studies suggests evolving influence changing work environment occurrence shift work common issue later studies points implications nurses psychosocial well conclusionsjob satisfaction problems nursing might responsive stress management intervention improving buffering effectiveness increased resilience prominent perceived job resource issues urgently required implications nursing managementparticipatory psychosocial methods potential raise job resources require high level collaboration stakeholders participative leadership facilitation managers enable better decision latitude support action planning responsive changes
background heart exposure ionizing irradiation cause ischaemic heart disease partial heart volume receiving heartv supposed independent prognostic factor survival radiochemotherapy locally advanced non small cell lung cancer nsclc validation latter hypothesis needed concurrent risks lung cancer patients patients methods espatue phase iii trial recruited patients potentially operable iiia selected iiib nsclc cisplatin paclitaxel induction chemotherapy given followed neoadjuvant radiochemotherapy bid concurrent cisplatin vinorelbine operable patients randomized definitive arm surgery arm therefore treated two different total dose levels radiotherapy heartv mean heart dose mhd obtained radiotherapy plans prognostic value analysed using multivariable proportional hazard analysis results total patients randomized espatue heartv mhd obtained radiotherapy plans male female median age years stage iiia iiib power analysis revealed power dataset detect prognostic value heartv size found rtog multivariable analysis identify heartv independent prognostic factor survival adjusting tumour clinical characteristics hazard ratio without lower lobe tumour location hazard ratio influence heartv death without tumour progression tumour progression pneumonia leading causes death representing observed deaths conclusions heartv could validated independent prognostic factor survival neoadjuvant definitive conformal radiochemotherapy tumour progression predominant cause death
like ester type biodiesel fuel green diesel next generation transportation fuel emerging due need renewable replacement internal combustion engine fuel also fully compatible existing automotive powertrain systems besides limitations main obstacle wider application renewable fuels relatively high production cost depending mainly raw material cost application efficient processing technology green diesel ester type biodiesel produced waste vegetable oil catalytic hydrogenation homogeneous alkali catalysed transesterification supercritical non catalytic transesterification techno economic analysis sensitivity analysis reveal economics production technologies strongly depend process unit capacity cost feedstock green diesel production catalytic hydroprocessing located petroleum refinery appears cost effective option unit capacity close tonnes year conventional ester biodiesel process non catalytic ester biodiesel process supercritical conditions less profitable specified capacity unit capacities investigated processes tonnes year likely result negative net present values years project lifetime elsevier ltd rights reserved
investigate cortical laminar degeneration parkinson disease dementia pdd changes density alpha synuclein immunoreactive lewy bodies lewy neurites lewy grains together surviving neurons abnormally enlarged neurons vacuoles glial cell nuclei measured across cortical laminae frontal temporal cortex fifteen cases pdd using quantitative methods polynomial curve fitting frequently distributed across laminae distributed upper cortical laminae low densities present cases distributed across cortical laminae densities vacuoles glia greatest upper lower cortical laminae respectively gyri spatial correlations densities cortical degeneration frontal temporal lobes pdd affects cortical laminae laminar distributions may result spread alpha synuclein pathology subcortical regions subsequent spread via cortico cortical pathways spread may major factor development dementia
emergency physicians regularly confronted ear nose throat ent emergencies main symptoms bleeding dyspnea dysphagia swelling causes foreign body ingestion injuries infections neoplasms allergies origin localization time interval essential diagnostic therapeutic measures estimated emergency management bleeding dyspnea main triggers acute respiratory distress inflammation abscesses anaphylactic reactions angioedema croup epiglottitis typical causes dyspnea children injuries larynx trachea require specific considerations respect intubation tracheotomy
organic agriculture rely synthetic chemical fungicides alternative pest management strategy chemical fungicides use bioactive natural compounds hordenine dimethylaminoethyl phenethylamine alkaloid found barley although hordenine various pharmacological effects including antibiotic activity microorganisms studies carried investigate inhibitory effects hordenine phytopathogenic fungal infection host plants grape downy mildew strawberry anthracnose suppressed hordenine treatment hordenine effect mycelial growth phytopathogenic fungi whereas plant defense response jasmonate dependent defense pathway enhanced hordenine treated plants concern environmental pollution led introduction new pesticides including bioactive natural compound based pesticide hordenine may used organic agriculture innovative elicitor plant defense response downy mildew anthracnose elsevier ltd rights reserved
paper presents simple efficient encryption scheme based controlled chaotic maps adpcm adaptive differential pulse code modulation coding order secure real time voice communication operating kbps encryption algorithm adopts three main operations one generate chaotic values using two chaotic logistic maps starting independent initial conditions second transform binary words using random encoding tables third execute basic operations substitutions important properties randomness pass nist batteries tests evaluation simulation analysis indicate proposal possesses excellent statistical cryptographic properties provides low correlation adjacent samples encryption speech extremely sensitive encryption keys large key space sufficient protect brute force attack illustrative example application commonly encoder type used communications standard itu presented
objectives evaluate efficacy adverse events flexibly adding oxybutynin patients overactive bladder oab refractory monotherapy first muscarinic antagonist methods total patients refractory oab enrolled prospective open label protocol inclusion criteria persistent symptoms partial response month behavioral therapy optimized dose one antimuscarinic agent baseline weeks oxybutynin day flexibly added assessed oab symptom indexes patient perception bladder condition uroflowmetry post void residual along therapeutic effect tolerability patients continuing combined antimuscarinic therapy followed months results compared baseline oab symptom indexes significantly decreased visits total patients reported successful therapeutic effect weeks respectively twenty four patients discontinued therapy weeks respectively patients continued combined medication months discontinuation combined medication noted patients due due lack efficacy conclusions flexibly adding second antimuscarinic agent effective safe oab patients dissatisfied first antimuscarinic treatment short term period patients dropout rate high long term efficacy combination two antimuscarinic agents limited
recently determining ramsey numbers loose paths cycles uniform hyper graphs received considerable attention shown color ramsey number uniform loose cycle asymptotically conjecture left perpendicular right perpendicular recently case proved authors paper first show conjecture true much shorter proof show fixed conjecture equivalent last equality finally give proof case elsevier rights reserved
background bipolar disorder characterized dysregulation affect impaired integration emotion cognition traits also expressed probands high genetic risk inferior frontal gyrus ifg key cortical hub circuits emotion cognitive control frequently associated studied resting state functional connectivity left ifg participants increased genetic risk methods using resting state functional magnetic resonance imaging compared young participants individuals least one first degree relative risk control subjects performed group analyses functional connectivity left ifg used graph theory study local functional network topology also used machine learning study classification based solely functional connectivity ifg results left ifg functionally dysconnected network regions including bilateral insulae ventrolateral prefrontal gyri superior temporal gyri putamen small network incorporating neighboring insular regions anterior cingulate cortex showed weaker functional connectivity risk control participants constellations regions overlapped frontolimbic regions machine learning classifier selected predicting group membership accuracy significantly greater chance conclusions functional dysconnectivity ifg regions involved emotional regulation may represent trait abnormality could potentially aid clinical diagnosis
chemical cross linking high molecular weight superabsorbent copolymers saps two main causes resistance biodegradation however sap particles colonized microorganisms purposes study dry technical copolymer acrylamide potassium acrylate containing unpolymerized monomers wrapped geotextile incubated unsterile haplic luvisol soil water absorbing geocomposite highest number soil bacteria colonized hydrated sap utilized sole carbon energy source found first month incubation soil equal log cfu water absorbed sap decreased log units within next months time initial sap water holding capacity decreased moreover sap dry mass declined two bacteria rhizobium radiobacter bacillus aryabhattai isolated watered sap found able biodegrade sap pure cultures destroyed technical sap day growth mineral burk salt medium biodegradation activity equal sap protein respectively aryabhattai radiobacter also able degrade ultra pure sap synthetic root exudate medium day growth respectively
global manufacturing companies must implement manufacturing engineering proper consideration given manufacturing process resources appropriate particularities manufacturing site particularly effective enterprise resource planning erp system implementation global manufacturing environment product data management pdm integration product data one important keys success product data integration engineering bill materials ebom needs transformed manufacturing bill materials mbom mbom transformation must done way fit particularities manufacturing site process methodology appropriate integration transformation required paper proposes digital manufacturing key tool data integration pdm erp digital manufacturing technology possessing physical logical computer modeling simulation technique actual manufacturing provides methodology transforming ebom mbom fits particularities manufacturing site based process resource models reflect particularities manufacturing site also provides methodology mbom verification process resource model integration using method mbom process resource data verified appropriate manufacturing site sent erp system
cross laminated timber one widely used engineered wood products thanks numerous advantages among construction speed appreciated clients designers however construction scheduling compression refers exclusively clt structures rest construction process still requires longer phase complete vertical enclosures aim research work presented paper outline advantages brought degree envelope prefabrication tall timber buildings increased results presented two sections first includes definition case study together overview possible technical details entirely prefabricated facade solutions ready installed without need work via scaffolds second deals construction site management analysis case study building determination specific factors influence time costs achieved varying prefabrication degree various facade configurations repeating analysis process main findings research work demonstrate comprehensive facade prefabrication allows consistent compression construction scheduling achieved also immediate protection wooden elements weather agents
paper presents experimental results concerning comparative monitoring lpg liquid petroleum gas petrol fuel combustion supplies electrical generator driven internal combustion system main pollutants monitored consequences cogeneration system shown results indicate even lpg less polluting gas nominal charge engine amount exhaust greenhouse gases increased hand price lpg low cost comparison fossil gasoline petrol advantage
paper improved particle swarm optimization ipso method based standard particle swarm optimization pso changing range genetic algorithm proposed applied form finding analysis suspension bridge installation new method integrated successive iteration method form finding analysis transfers usual iterative process form finding analysis single objective optimization problem computation formulation computer code ipso developed implemented benchmark examples studied test performance ipso method numerical experiments results show ipso used viable solution methodology form finding analysis various initial boundary complicated load conditions overcome limitations conventional newton raphson iterative method furthermore compared pso pso ipso greater accuracy efficiency finally method applied actual form finding analysis multitower suspension bridge yingwuzhou yangtze river bridge validate practicality feasibility ipso based method engineering design case study indicates ipso provides superior convergent solutions analysis considered compared method computation time affordable large scale engineering bridge construction design analysis
finite element model sutong cable stayed bridge scb established based ansys dynamic characteristics bridge analyzed using subspace iteration method based recorded wind data measured spectra expression presented using nonlinear least squares regression method turbulent winds bridge site simulated based spectral representation method fft technique influence key structural parameters measures dynamic characteristics bridge investigated parameters include dead load intensity well vertical lateral torsional stiffness steel box girder addition influence elastic stiffness connection device employed towers girder vibration mode steel box girder investigated analysis shows vertical lateral torsional buffeting displacement responses reduce gradually dead load intensity increases dynamic characteristics structural buffeting displacement response scb slightly affected vertical torsional stiffness steel box girder lateral torsional buffeting displacement responses reduce gradually lateral stiffness increases results provide reference dynamic analysis design super long span cable stayed bridges
background aim study determine whether polymorphisms toll like receptor tlr confer susceptibility rheumatoid arthritis juvenile idiopathic arthritis jia central south chinese han population methods genotyping six well studied polymorphisms tlr gene conducted unrelated patients healthy control subjects well unrelated patients jia healthy control subjects using direct sequencing technique comparisons cases controls alleles genotypes haplotypes carried using fisher exact test results significant genetic associations detected utr rsc adj jia padj addition rsg found significantly associated susceptibility adj jia adj furthermore significant increasing distributions haplotypes jia also found moreover frequency rsc significantly increased positive anti ccp positive subjects anti ccp jia anti ccp conclusions study suggested tlr might contribute might contribute jia pathogenesis central south chinese han population
previous studies show close friends improve lie detection time however improvement due increase ability decode feelings close friends change close friends communicate true deceptive emotions study pairs friends one friend pair sender videotaped showing truthful faked affect response pleasant unpleasant movie clips friend pair judge guessed true emotions friend stranger month months friendship judges better guessing true emotions friends strangers advantage judging friends increased among close friends time surprisingly improvement time due mostly change sender communication rather increase judges ability decode friends feelings
suspended cables including transmission lines suspension bridge cables edge cables roof structures feature high profile large span projects architectural reasons functional efficiency ease construction particularly large spans suspended cable predominantly reacts external loads means axial tension therefore able make full use material strength slenderness suspended cable structural response nonlinear even material property within elastic range mechanics perspective therefore types structure exhibit high levels geometric non linearity reason nonlinear relationships tension force normal displacement external loads need considered aiming determine structural safety suspended cable understand uncertainty features greatest influence relationships written within probabilistic framework article briefly sets analysis suspended cables within context geometrically nonlinear elastic structures corresponding finite element analysis methodologies analytical solutions tension normal displacement suspended cable subjected external loading presented nonlinear performance functions form either cable tension normal displacement stated analytical expressions required gradients performance function suspended cable respect basic variables static loads developed structural reliability suspended cable studied using first order reliability method fosm verified comparison monte carlo simulation mcs monte carlo simulation based optimization principles mcop number examples load cases including wind snow temperature variation included elsevier ltd rights reserved
principle group delay swing enhancement transmission line pass network using combined coupling dispersion boosting properties ferromagnetic substrate proposed full wave verified experimentally demonstrated using ferrite substrates proof concept proposed group delay swing enhanced structures compact size exhibiting larger dispersion per unit area compared alternative techniques dispersion enhancement magnetically tunable group delay swing proposal suppress requirement external magnet discussed based self biased ferromagnetic nanowire substrates expected improvements pointed wiley periodicals inc microwave opt technol lett view article online wileyonlinelibrary com doi mop
taking runyang highway bridge yangtze river main span example structural response bridge horizontal vertical seismic excitations investigated response spectrum time history analysis midas civil software respectively seismic behavior influence structural nonlinearity seismic response bridge revealed considering aspect seismic performance suitability employing suspension bridge super long span bridges investigated compared cable stayed bridge cable stayed suspension hybrid bridge similar main span furthermore effects structural parameters including span arrangement cable sag span ratio side main span ratio girder height central buckle girder support system etc seismic performance bridge investigated seismic response spectrum analysis favorable earthquake resistant structural system suspension bridges also discussed
scientific technological innovation become key component economic growth policies geared towards reinforcing education areas become priority due exponential growth technologies based relaying software one key skills identified basic literacy future computer programming consequence several countries taking steps introduce coding education however speed skill becoming essential demands prompt introduction levels steps taken primary secondary education widely discussed extent computer programming introduced higher education less known universities addressing demand taking design education case study approach questions asking faculty design schools different countries whether respective institutions offer computer programming courses modality laying theoretical framework discussion use mix qualitative interviews questionnaires gather information finally discuss steps taken primary secondary education could serve reference higher education close reflecting upon implications information obtained develop work force capable using technology creating authors published elsevier ltd
introduction low testosterone levels low increase cardiovascular risk men erectile dysfunction levels associated higher risk unknown aim determine prevalence risk factors associated low defined european guidelines contribution low overall different ages methods multicenter cross sectional observational study conducted spain among men aged years visiting urology andrology offices sexual dysfunction anthropometric clinical laboratory data including total values collected men main outcome measures risk factors assessed men nmol two group comparisons made bivariate multivariate logistic regression analyses performed calculate odds ratios low adjusting possible confounding factors results mean age standard deviation years age prevalence risk factors similar men nmol low therefore considered nmol prevalence obesity hypertension hyperlipidemia severe variables strongly associated low obesity middle aged men hyperlipidemia hypertension older men severe risk factor groups hypolipidemic therapy greater effect young men multivariate analysis showed severe obesity strongest predictors low conclusion levels associated increased risk could high nmol men distribution risk factors showing differences according age obesity severe best predictors low related risk
paper describes use domain decomposition methods accelerating wave physics simulation numerical wave based methods provide accurate simulation geometrical methods higher computation cost well context virtual reality quality results estimated according human perception makes geometrical methods interesting approach achieving real time physically based rendering investigate geometrical method based beams rays tracing enhance two levels parallel processing techniques domain decomposition methods coupled classical parallel computing shared distributed memory optic acoustic renderings experimented evaluate acceleration impact domain decomposition scheme speedup measurements clearly show efficiency using domain decomposition methods real time simulation wave physics copyright john wiley sons ltd
literature studies showed ability treat neuropsychiatric disorders using coil developed deep transcranial magnetic stimulation dtms despite positive results clinical studies electric field distributions inside brain induced coil positioned scalp according clinical studies yet precisely estimated study aims characterize distributions due coil brain two realistic human models computational electromagnetic techniques compare ones due figure coil traditionally used tms positioned simulate clinical experiments despite inter individual differences results show dorsolateral prefrontal cortex region preferentially stimulated figure coil placed position scalp according clinical studies broad non focal distribution case coil moreover coil spreads figure coil prefrontal cortex medial prefrontal cortex towards deeper brain structures characterized higher penetration depth frontal lobe work highlights importance knowledge electric field distribution brain tissues interpret outcomes experimental studies optimize treatments ipem published elsevier ltd rights reserved
amyotrophic lateral sclerosis als frontotemporal degeneration parkinson disease may different expressions neurodegenerative disease however association als parkinsonism dementia complex als pdc rarely reported apart cluster detected guam report patient presenting als pdc pathological mutations expansions investigated family members reported symptoms neurological condition case demonstrates als pdc occur sporadic disorder even though coexistence three clinical features one patient suggests single underlying genetic cause known genetic testing preferentially offered patients als affected first second degree relatives however case illustrates importance genetic counseling family members patients sporadic alc pdc order provide education low recurrence risk dicuss ethical psychological practical consequences patients relatives
excessive motions buildings cause occupants become uncomfortable nervous particularly detrimental tenants ultimately owner building respect financial considerations serviceability issues excessive accelerations inter story drifts prevalent today due advancements structural systems strength materials design practices factors allow buildings taller lighter flexible thereby exacerbating impact dynamic responses growing need innovative effective techniques reduce serviceability responses tall buildings current study considers case study real building show effectiveness robustness tld reducing coupled lateral torsional motion high rise building wind loading three unique multi modal tld systems designed specifically mitigate torsional response building procedure developed analyze structure tld system using high frequency force balance hffb test data boundary layer wind tunnel laboratory blwtl university western ontario effectiveness unique tld systems investigated addition parametric study conducted determine robustness systems reducing serviceability responses three practical parameters varied investigate robustness tld system height water inside tanks amplitude modification factor structural modal frequencies
lateral ankle sprains among common sports injuries prevalence injuries least one third individuals develop long term complaints chronic instabilities ankle many cases attributed mechanical insufficiencies joint condition referred functional ankle instability fai impairments sensorimotor control system disturbed proprioception postural control well reduced muscle strength reflex activity suggested contribute aetiology fai review summarises current body literature regarding sensorimotor control individuals fai discuss results context current neurophysiological models development functional joint instabilities
background aims assess prevalence correlates addictive like eating behavior germany methods german version yale food addiction scale yfas used investigate first time prevalence food addiction representative sample aged years results prevalence food addiction measured yfas individuals meeting criteria food addiction higher bmi younger individuals meeting threshold underweight obese individuals exhibited highest prevalence rate food addiction addictive like eating associated sex education level place residence conclusion yfas food addiction met nearly population non linear relationship addictive like eating bmi highest prevalence among underweight obese persons findings suggest food addiction may contributor overeating may also reflect distinct phenotype problematic eating behavior synonymous obesity elevated prevalence yfas food addiction among underweight individuals may reflect overlap eating disorders warrants attention future research author published karger gmbh freiburg
biomedical synthetic biology emerging field cells engineered genetic level carry novel functions relevance biomedical industrial applications approach promises new treatments imaging tools diagnostics diseases ranging gastrointestinal inflammatory syndromes cancer diabetes neurodegeneration cellular technologies undergo pre clinical clinical development becoming essential monitor location function vivo necessitating appropriate molecular imaging strategies therefore created interest group within world molecular imaging society focusing synthetic biology reporter gene technologies highlight recent advances biomedical synthetic biology including bacterial therapy immunotherapy regenerative medicine discuss emerging molecular imaging approaches facilitate vivo applications focusing reporter genes noninvasive modalities magnetic resonance ultrasound photoacoustic imaging bioluminescence radionuclear imaging reporter genes incorporated directly engineered genetic circuits particularly well suited imaging synthetic biological constructs developing provides opportunities creative molecular genetic engineering
article provides overview digital video broadcasting satellite dvb specifications context extension mobility different ways receiving digital television mobile devices summarized overall demonstrator antenna baseband signal processing presented attention paid analog channel selection qpsk frequency demodulation noise issues deeply developed paper finally new technique wipe technique improving noise performances suggested claimed dvb fulfills requirements extend fixed reception toward mobility band large area coverage good quality received signals reduced total network cost low power consumption thanks full analog signal processing channel selection
background studies evaluated effect adherence lifestyle intervention adolescent health outcomes objective study determine whether adolescent parental adherence components health intervention resulted change adolescent body mass index bmi waist circumference scores sample overweight obese adolescents methods total overweight obese adolescents parents participated month health lifestyle intervention week adolescents parents asked login respective website monitor dietary physical activity sedentary behaviours examined participation percentage webpages viewed adolescents number weeks logged parents self monitoring number weeks behaviors tracked rates linear mixed models multiple regressions used examine change adolescent bmi scores predictors adolescent participation self monitoring respectively results adolescents parents completed respectively online component intervention higher adolescent participation rate associated decrease slope bmi score change score association found self monitoring rate change adolescent bmi scores parent participation found moderate relationship adolescent participation weight outcomes conclusions developing strategies engaging promoting supportive interactions adolescents parents needed health context findings demonstrate improving adolescents adherence health lifestyle intervention effectively alter weight trajectory overweight obese adolescents
despite similar roles work home ever men women continue exhibit different travel behavior open question whether remaining gender differences travel differ traditional emergent aspects household structure spouse partner presence parenthood breadwinner status using data american time use survey study offers unique empirical travel time analysis metropolitan workers stratified household structure results show gender differences travel time respond multiple aspects household structure complex interactive ways gender difference work travel time observable spouse partner presence parenthood interact couple households children gender difference household support travel reacts parenthood spouse partner presence gender difference travel time employed females employed males single breadwinner couples different gender difference double breadwinner couples results call policy initiatives research inquiries pay greater attention large gender disparities work travel couple households children large gender disparities household support travel households children including single parent households although incapable ruling influences internalized gender differences preference theory gendered structural contexts labor market segmentation findings provide clear evidence traditional gender roles relations remain operative contemporary households
digestive health expanding area nutrition research due interest food components fiber affect gastrointestinal tolerance stool form defecation frequency transit time gut microbial composition metabolic activity children however digestive health studies intervene dietary fiber limited due legal ethical concerns better understand fiber improves digestive health children literature review conducted answer following research question effect fiber containing foods supplements digestive health outcomes children search pubmed database identified total studies fit inclusion criteria established review evidence children shows beneficial effects partially hydrolyzed guar gum glucomannan bran digestive health outcomes however existing evidence conclusive furthermore limited data exists effect whole grain sources dietary fiber oats additional well designed intervention trials needed determine whether outcomes digestive health stool form gastrointestinal tolerance stool frequency improved increasing fiber content children diets whole grain sources
religious service attendance predicts increased well across number studies clear however whether relationship due religious factors intrinsic religiosity due nonreligious factors social support socially desirable responding purpose present study examine relationship religious service attendance well simultaneously examining intrinsic religiosity social support socially desirable responding potential mediators relationship sample participants female average age completed questionnaires assessing religiosity social support socially desirable responding well path models estimated using maximum likelihood estimation analyze data intrinsic religiosity strongest mediator relationship religious service attendance depressive anxiety symptoms suggests mental health benefits religious service attendance simply result increased social support certain response style questionnaires rather appears relationship least partly result people trying live religion daily lives
atopic dermatitis extremely common condition affecting many children adults particularly distressing symptom pruritus one important aspects inflammation associated increased activity phosphodiesterase pde resulting decreased intracellular levels cyclic adenosine monophosphate turn causes increased production inflammatory cytokines crisaborole developed small molecule boron based selective pde inhibitor used topically clinical trials demonstrated efficacy treating patients mild moderate resulting significant relief pruritus unlike pde inhibitors act systemically crisaborole cause significant gastrointestinal adverse effects common adverse effect temporary stinging burning patients upon application ointment date evidence atrophy telangiectasia hypopigmentation resulting use crisaborole first topically applied pde inhibitor approved fda use
objectives electroconvulsive therapy ect demonstrated efficacy treating core symptoms parkinson disease however widespread use ect limited due concern cognitive burden investigated use newer ect technology known fewer cognitive side effects right unilateral rul ultra brief pulse ubp treatment medically refractory psychiatric dysfunction materials methods open label pilot study included patients assessed motoric cognitive neuropsychiatric domains prior rul ubp ect primary endpoints changes total score ham gds rating scales results patients found improve motoric psychiatric domains following rul ubp ect without cognitive side effects immediately following ect month follow conclusions study demonstrates rul ubp ect safe feasible potentially efficacious treating multiple domains including motor mood without clear cognitive side effects
aim study perform morphometric analysis different structural tissue layers goat stomach study prenatal growth mathematical models fitted morphometric data total embryos fetuses used early stages prenatal life birth growth rate gastric wall slower body length rumen stomach compartment displaying slowest growth three non glandular compartments epithelial layer grew faster gastric wall growth rate abomasal epithelium declined early stages development decline growth rate also observed lamina propria submucosa rumen reticulum early embryonic stages whereas omasum abomasum layers continued grow gestation progressed tunica muscularis displayed consistent growth compartments growing faster gastric wall serosa thickness increased gestation progressed displaying decline growth rate omasum conclusion dynamics gastric wall growth governed growth rate component tissue layers
background prevalence drug resistant tuberculosis xinjiang higher regions china beijing lineage mycobacterium tuberculosis mtb dominant strain mtb xinjiang however information multidrug resistant mdr extensively drug resistant xdr particularly correlation mdr beijing lineage correlation drug resistance beijing sublineage strains limited material methods conducted prospective study describe prevalence mdr xdr beijing lineage sublineage strains xinjiang china mtb underwent drug susceptibility testing first second line anti tuberculosis drugs beijing lineages sublineages detected large sequence polymorphisms polymerase chain reaction results total clinical isolates identified overall percentage mdr xdr cases xinjiang respectively overall beijing lineage mtb mdr patients non beijing lineage mtb mdr patients beijing mtb lineages isolates sublineage isolates sublineage isolates sublineage isolates sublineage none isolates detected sublineage significant differences beijing non beijing strains observed regarding inh emb resistance respectively conclusions prevalence mdr xinjiang remains high imposes challenges control four beijing sublineage isolates observed xinjiang correlation mdr beijing lineage correlation drug resistance beijing sublineage strains surveillance clinical isolates mtb recommended strengthen identification mdr xdr sublineages beijing strains
although decision engage prosocial behavior received research attention literature offers limited understanding fairness uncertainty antecedents propose one encourage prosocial decision making simply invoking notion fairness effects perceived trustworthiness invoking party also elucidate complex role uncertainty prosocial decisions negative effect also serving strengthen positive effect fairness salience ideas tested two prosocial decision contexts including participative pricing pay want charitable giving data archival study naturally occurring event two controlled experiments offer support arguments copyright john wiley sons ltd
background testosterone dehydroepiandrosterone sulphate dheas neurosteroids deficiencies constitute hormone risk factors promoting development depression elderly otherwise healthy men investigated link hypogonadism depression accordance age concomitant diseases men systolic using novel scale previously dedicated elderly population methods analysed prevalence depression severity depressive symptoms population men systolic years compared healthy peers severity depression assessed using polish long version geriatric depression scale gds results men aged years severity depressive symptoms greater nyha classes iii compared nyha classes reference group men aged years depressive symptoms severe nyha class iii compared controls multivariate logistic regression model men aged years advanced nyha class associated higher prevalence mild depression chronic obstructive pulmonary disease copd higher prevalence severe depression men aged years advanced nyha class deficiency related higher prevalence mild depression respectively conclusion deficiency copd advanced nyha class associated higher prevalence depression men systolic
paper introduces technique derive wordlevel abstraction function implemented combinational logic circuit abstraction provides canonical representation function polynomial finite field represent bit output input bit vectors words circuit respectively canonical abstraction utilized formal verification equivalence checking combinational circuits approach abstraction based upon concepts computational commutative algebra algebraic geometry show abstraction derived computing grobner basis polynomials corresponding circuit using specific elimination term order derived circuit topology computing grobner bases using elimination term orders infeasible large circuits overcome limitation describe efficient symbolic computation derive word level polynomial algorithms exploit structure circuit properties grobner bases characteristics finite fields modern algorithms symbolic algebra derive canonical polynomial representation approach employed verify detect bugs large combinational finite field arithmetic circuits contemporary verification techniques known infeasible
multi hop relaying systems many relay stations rss cognitive radio technique improve system performance greatly due efficient resource sharing rss letter performance arq mechanism based multi hop relaying systems studied using markov chain matrix signal flow graph msfg techniques also priority based resource allocation scheme proposed prevent performance degradation caused usage unstable resources acquired technique
examined women aged years mean age years secondary amenorrhea complaining frequent urination years repeatedly unsuccessful treated overactive bladder chronic cystitis rare cause sustained urination disorders young female patients reproductive age established development secondary amenorrhea caused weight loss cosmetic amenorrhea subsequent estrogene deficit urogenital atrophy morphological examination bladder mucosa important clue diagnosis helps identify true cause dysuria urogenital atrophy bladder mucosa secondary cosmetic amenorrhea determine future course etiopathogenic treatment sustained dysuria young women treatment often effective case proper timely diagnosis absence irreversible changes
past years excessive use fossil fuel posed serious problems greenhouse effect environmental pollution threaten human life regarded ideal substitution traditional internal combustion engine low temperature proton exchange membrane fuel cell pemfc converts chemical energy electrode reaction directly electrical energy high efficiency low pollution however main problem behind industrialization pemfc oxygen reduction reaction orr occurring cathode needs precious metal platinum catalyst limited reserve costly owing high activity stability graphenes doped non metal proven excellent alternatives experimentally however relevant theoretical work scarce adsorptions orr intermediates ooh doped graphenes essential cathode reaction also bring difficulties next step reaction therefore paper based density functional theory adsorption characteristics ooh doped doped codoped graphenes studied using first principles calculation code vasp first analyzing adsorption energies bond lengths densities states charge transfers influences different dopants intermediates evaluated orr steps discussed free energy change step given results show doped doped graphenes adsorption energies various intermediates exhibit similar linear relationships adsorption energy ooh doped graphene much larger doped grapheme large adsorption energy doped graphene beneficial fracture reaction bond ooh small adsorption energy doped graphene promote reaction converting water owing synergistic effect graphene codoped possesses better catalyzing ability single doped ones results helpful understanding excellent performances codoped graphenes
increasing applications large diameter long span cables key structural components cable supported structures becoming evident however cables accumulate damage time life cycle damage needs detected avoid detrimental influences serviceability ultimate capacity structure context vibration based damage detection vbdd methods used structures cable structures however exhibit complex vibration patterns namely vertical lateral torsional coupled modes complicate vbdd procedure address matter paper proposes new approach detecting locating damage cables using component specific damage indices dis based modal flexibility method considering modal mass participation application new procedure illustrated two case studies suspended cable three dimensional suspension bridge structure results verify dls based lateral vertical components mode shapes identified modal mass participation factors effective detecting locating damage suspended cables main cables suspension bridge respectively range damage scenarios research outcomes paper confirm modal mass participation factor important signature damage detection structure using vbdd techniques
paper describes basic approach building general purpose miso fita multiple inputs single output rule based system fuzzy logic inference system also discussed classic simplified models inference systems optimization methods architecture fuzzy engine proposed system based simplified mamdani fuzzy inference model implemented sample platform based armv cortex microcontroller performance fuzzy inference system defined time obtain output crisp inference result higher comparable another software hardware solutions proposed system even takes elsevier rights reserved
algorithm design analysis core course computer related professional also comprehensive practical course therefore good teaching effect improve students ability logical thinking also beneficial students improve ability programming practice paper referencing teaching reform achievements algorithm design analysis domestic key universities teacher analyzed teaching situation algorithm design analysis college aiming shortcomings past teaching process organization proposed teaching organization mode framework algorithm design analysis order cultivate students ability programming practice electived algorithm design analysis course implementation organization framework students improve exercise programming practice ability
objectivessome researchers suggest borderline personality disorder bpd characterized elevated negative emotion others argue bpd involves reduced positive increased negative emotion study characterizes emotional experiences individuals bpd symptoms combined university community sample methodparticipants completed clinical interview assessing bpd symptoms self report measures positive negative emotion subset completed measure emotion daily weeks pearson correlations multilevel modeling used examine cross sectional longitudinal relationships bpd symptoms emotions resultsbpd symptoms robustly related increased negative emotion relationship remained accounting positive emotion bpd symptoms weakly related decreased positive emotion relationship longer significant accounting negative emotion bpd symptoms predicted higher levels negative positive emotion days patterns held subscales assessing intensity frequency duration negative positive emotions conclusionfindings suggest individuals bpd features chiefly distinguished elevated negative emotional experience
small electrical generator based vibrations using efficient electromagnetic transduction mechanism presented system using magnetic core made finemet nanocrystalline ribbons specific magnetic properties harvest convert energy vibrations active energy maximum efficiency system consists pair movable magnets attached elastic lamella working cantilever fixed coil subjected vibrations oscillation permanent magnets induces electromotive force coil surrounding magnetic core model simulates behavior small electrical generator proposed model provides information influence different parameters transduction mechanism optimal conversion efficiency reliability system extremely useful properly design energy harvester
water pollution one pervasive problems afflicting people world adsorption impactful method remove organic pollutants water demonstrate facile efficient approach extendable prepare porous polyurea monolith new type adsorbent water purification research order obtain porous polyurea monolith reaction tdi monomer vapor using centrifugally spinning moulding prepared notably results show centrifugally spinning moulding effective method form whole block structure according specific surface area pore size pore size distribution porous polyurea monolith affected different centrifugal speeds porous polyurea monolith continuous interconnected fiber like clusters skeletal structure composed mesopores maropores moreover porous polyurea monolith could adsorb oils organic solvents water fast attribute highly hydrophobic oleophilic properties elsevier rights reserved
background parkinson disease degenerative disorder central nervous system mainly affecting motor functions including voice aetiology dysphonia changes throughout course disease progression objectives study aimed determine laryngeal changes seen early mid late stage parkinson disease thirteen patients parkinson disease presented representing largest series voice patients parkinson disease seen voice clinic literature method age gender severity handicap caused voice disorder possible associated reflux symptoms examined results laryngeal function appeared change gradually progression disease may affected presence pre existing laryngeal pathology conclusion laryngeal function parkinson disease appears series changes may helped therapeutic surgical interventions patients treated within confines voice clinic multidisciplinary model
security essential enable internet things iot key security measures work well traditional internet however necessarily adapt well iot specifically authentication authorization based certificates provided certificate authorities cas current form scale expected billion devices widely used encryption technologies internet require much energy resource constrained devices paper describes secure network architecture key distribution mechanisms using local automated authorization entities architecture provides security guarantees addressing iot related issues including resource constraints evaluation show architecture overhead scales significantly slower rate widely used ssl tls works well resource constrained devices
current study examines whether autonomy supportive controlling parenting related presence absence binge eating purging behavior non suicidal self injury adolescents eating disorder fifty three patients completed validated questionnaires assessing perceived maternal paternal autonomy supportive psychologically controlling parenting total mothers fathers also completed questionnaires patients completed self injury questionnaire treatment related assess non suicidal self injury nssi results showed patients binge eating purging behaviors experienced maternal psychological control compared restrictive patients independently presence nssi paternal psychological control autonomy support differ function subtype presence absence nssi results suggest especially mothers patients engaging binge eating purging behaviors could benefit family interventions support parents diminishing use psychological control
inverted pendulum classical control problem absolutely unstable system characteristics higher order unstable multivariable nonlinear strong coupling varieties methods applied control inverted pendulum system pid control optimal control robust control sliding mode control fuzzy control neural network control human imitating intelligent control paper firstly using principle newtonian mechanics mathematical model inverted pendulum system established differential equations state space representation derived secondly controller designed using linear quadratic regulator lqr cost equation thirdly pid controller designed tuning pid parameters focused finally simulation results show inverted pendulum could balanced controllers
background increasing need exists suitable measures evaluate treatment outcome adolescents core pan theoretical brief questionnaire developed purpose lacks studies different cultures languages aims explore acceptability factor structure reliability validity sensitivity change finnish translation core methods study conducted department adolescent psychiatry helsinki university central hospital finnish translation prepared team professionals adolescents clinical sample patients asked complete form together bdi bai filled forms month treatment analysis included acceptability confirmatory factor analysis internal test test reliability concurrent validity influence gender age criteria reliable change results core well accepted rate missing values low internal consistency test test reliability good results cfa supported one factor model core showed good concurrent validity two widely used symptom specific measures gender moderately strong effect scores effect age evident measure sensitive change showing larger effect size bdi bai conclusions results show translation core finnish successful core good psychometric properties measure could taken wider use clinical settings outcome measurement adolescents
based green building development become inevitable trend promote urban development pattern transformation realize city green ecology sustainable development circumstances becomes important apply green building assessment system scientifically accurately whether green building real energy saving operation stage paper use established poe system environmental performance green residential building make case study green residential building cold region aims verifying scientificity rigor evaluation poe system provides technical support green residential building country related work authors published elsevier ltd
resources environmental issues increasingly becoming focus global global economy moving industrial agricultural economy tertiary industry service economy modern services include consumer services producer services modern logistics industry one major producer services development must depend appropriate logistics professionals building logistics professionals adaptation producing services imperative trend producing services global economy need review modify enrich perfect logistics management professional training scheme teaching course system article first expounds concept producing services relationship logistics producer services discusses construction teachers team construction practical teaching system perspective curriculum system thereby builds logistics management subject construction scheme private colleges modern service industry development trend
paper proposes new operation control strategy power assisted wheelchairs paw using one brushless bldc motor conventional electrical wheelchairs heavy large one person move two electric motor wheels hand proposed paw system small volume easy move due presence single wheel motor unlike conventional electric wheelchairs structure paw control joystick reduce weight volume control wheelchair without joystick special control system algorithm needed proper operation wheelchair proposed paw system uses one sensor detect acceleration direction paw movement using sensor speed control achieved speed control system three kinds operations done speed paw increment paw speed summing external force decrement paw speed subtracting external force emergency breaking evaluating time duration external force validity proposed algorithm verified experimental results
objective relationship urbanisation symptom prevalence asthma rhinoconjunctivitis eczema clear varying definitions urban extent used furthermore global analysis undertaken study aimed determine whether symptom prevalence asthma rhinoconjunctivitis eczema centres involved international study asthma allergies childhood isaac higher urban rural centres using definition urban extent land cover satellite data methods global map urban extent satellite images mod map used define urban extent criterion maps isaac centres digitised merged mod map describe urban percentage centre investigated association symptom prevalence asthma rhinoconjunctivitis eczema percentage urban extent centre results weak negative relationship found percentage urban extent isaac centre current wheeze year age group association statistically significant adjusting region world gross national income relationship found urban extent symptoms asthma rhinoconjunctivitis eczema conclusions study prevalence symptoms asthma rhinoconjunctivitis eczema children associated urbanisation according land cover definition urban extent satellite data comparable standardised definitions urbanisation need developed global comparisons made
computer input output subsystem functioning abstract concepts difficult undergraduate freshmen understand however important freshmen assimilate low level concepts going taught operating systems working architecture layer working directly embedded systems real time systems area humancomputer interaction hci article describes use game console nintendo nds project based learning pbl pjbl environment design game basis project order encourage students get involved computer subsystem abstraction experience reported action research model planning acting observing reflecting followed general procedure specific characteristics achieved results year reported aim study twofold assess learning effectiveness active pjbl educational approach related factors analyze motivation toward subject fostered game console first aim analyzed using scores achieved students second aim analyzed via satisfaction questionnaires
purpose childhood cancer survivors ccs increased risk primary gonadal insufficiency pgi study evaluated prevalence clinical characteristics pgi ccs methods single center retrospective observational longitudinal study characterized ccs pgi attending oncology long term follow ltfu clinic australian university hospital january august cohort ccs males met criteria pgi elevated gonadotropins plus low estradiol amenorrhoea females low testosterone small testicles age males results median age primary diagnosis years inter quartile range iqr years ltfu years iqr years fifty three participants treated known highly gonadotoxic therapies alkylating chemotherapy radiotherapy total body irradiation bone marrow transplantation multimodal protocols primary diagnosis participants tanner stage ltfu participants tanner stage females males treated hormone development therapy hdt half males required pubertal induction significant difference serum luteinizing hormone follicle stimulating hormone fsh testosterone estradiol untreated treated hdt among hdt persistently elevated fshlh low testosterone estradiol six males semen analysis five azoospermic one oligospermic psychological assessment documented participants two thirds reported fertility concerns conclusion pgi evolving phenotype common ccs suboptimal treatment non adherence occur frequently ongoing assessment essential ensure prompt diagnosis adequate intervention promote hdt adherence
recently efforts undertaken develop nanostructured materials enhanced mechanical microstructural properties use various fields materials engineering purpose present study help clarify optimize overall processing parameters high frequency induction heat sintering hfihs process sintering temperatures times pressures heating rates focusing sintering nanostructured powders suitability hfihs process combining high sintering density inhibited grain growth study super fast densification behavior attendant mechanical microstructural features magnesium hydroxyapatite hap bio nanocomposites processed hfihs investigated results indicate nano grained nearly fully dense hap nanostructure small crystal size could obtained optimizing overall processing parameters relative density microhardness compressive strength nanocomposite approximately mpa respectively obtained phase analysis using ray diffraction xrd shows major variations product starting materials elsevier ltd rights reserved
paper presents high polarization wide angle independentmetamaterial absorber based triple hexagonal shaped resonators metamaterial unit cell absorber possesses nearly wide angle perfect absorption incidence wave polarization independence absorption occurred three different frequencies absorptivity high ghz ghz ghz respectively simulation simulation agrees well experiments regarding return loss absorption important features method simple fabrication metamaterial absorber maximum absorption three frequencies proposed metamaterial absorber wide applications thermal detector stealth technology imaging moreover good agreement simulation measurement results observed
understand role tattooists play providing skin care advice conducted online survey based study licensed tattooists new york city survey asked tattooists exposure adverse tattoo events advising tattoo removal correction behaviors regarding preexisting skin conditions aftercare confidence addressing client questions adverse events preexisting conditions prior training skin conditions related tattoos tattooists reported asked clients evaluate adverse tattoo reactions asked tattoo removal asked safety getting tattoo preexisting skin condition half received training skin conditions related tattoos tattooists prior training reported higher rates optimal skin care behaviors higher confidence tattoo related skin conditions reported interest skin care education tattooists play major role skin health clients providing education tattooists may improve skin care populations less likely see dermatologist karger basel
objective estimate time hiv infection linkage care determinants linkage care usually assessed using date hiv diagnosis starting point exposure time however timing diagnosis likely endogenous linkage leading bias linkage estimation design used longitudinal hiv serosurvey data large population based hiv incidence cohort kwazulu natal estimate time hiv infection linked data patient records public sector hiv treatment care program determine time infection linkage defined using date first cell count methods used cox proportional hazards models estimate time infection linkage effects following covariates time sex age education food security socioeconomic status area residence distance clinics knowledge hiv status whether household members initiated antiretroviral therapy results estimated would take average years hiv seroconverters linked care confidence intervals among cohort members linked care median cell count linkage cells confidence interval men participants aged less years found slowest rates linkage care time linkage became shorter calendar time conclusion average time hiv infection linkage care long needs reduced ensure hiv treatment prevention policies effective targeted interventions men young individuals largest potential improve linkage rates copyright wolters kluwer health inc rights reserved
generally speaking hydraulic control systems divided two different driving concepts first one well known valve controlled system second one pump controlled system former possesses feature fast dynamic response however poor energy saving performance major fault contrary pump controlled hydraulic system significant advantage energy saving meets current demand modern machine design paper simulation analysis using matlab simulink dshplus newly developed energy saving hydraulic tube bender conducted instead conventional fixed displacement hydraulic pump new hydraulic tube bender utilizes internal gear pump servomotor driving power source new energy saving hydraulic circuit use conventional pressure relief valve longer necessary since demanded flow rate pressure output precisely obtained continuously changing speed servomotor addition simulation results shown energy saving performance load sensing control scheme somewhat better constant pressure control scheme furthermore simulation results also show newly developed hydraulic tube bender save energy consumption working cycle compared conventional hydraulic tube bender elsevier ltd open access article license
prostatic carcinoma second commonest cancer males common become almost holoendemic advancing age recent demonstration far benign benign pro static hypertrophy likely reaction prostate chronic untreated lower genital tract infection chronic inflammation likely usual precursor frequent occurrence prostatic carcinoma far reaching implications obvious source chronic inflammatory stimulus prostate documented dramatically altered lower female genital microbiota associated menopause hence major hypothesis prostatic cancer may arise due chronic infection inflammation prostate gland consequent upon altered microbiome menopausal female genital tract implications testing diagnosis treatment population health personal hygiene practices suggests male dyspareunia although almost never encountered clinical practice may fact relatively common older males particular diagnosed represents critical opportunity therapeutic intervention interrupt chronic inflammation cancer transformation progression well documented tissues implies coordinated application next generation sequencing microbiome lower genital tracts male female couples including seminal fluid research applications explore sequence well finding application potential population level screening procedure presently done thin prep cervical screening human papillomavirus females moreover insight opens new opportunities chemointervention chemoprevention important clnicopathological progression considerations give rise exciting possibility prostatic malignancy may preventable various methods local hygiene female partner antibacterial method males since long term application oral antibiotics likely limited efficacy indicates need new antimicrobial solutions elsevier ltd rights reserved
research suggests self compassionate myriad benefits including life satisfaction health promoting behaviours improved mental health given possible advantages self compassionate seems critical explore promote general population qualitative study aimed understand responses idea compassionate oneself within general population semi structured interviews conducted north east england october february analysed using thematic analysis part intervention study non clinical volunteers watched psychoeducation video concept self compassion participated one four meditation exercises following participants interviewed responses idea self compassionate three themes identified benefits self compassion self compassionate barriers self compassion participants believed self compassionate would beneficial world believed self compassion would make vulnerable others would judge thus participants afraid first ones self compassionate stated order self compassion acceptable need change perspective western culture findings underscore importance understanding society role person ability self compassionate order reap benefits self compassion need create culture accepts encourages practitioners position lead self compassion encourage leaders promote preventative mental health strategy
intelligent cameras smart cameras often referred appear ubiquitously everyday lives home work pockets bags cars homes experiencing interacting new generation smart cameras far surpass ability merely capture images provide high level descriptions environment analyse see recently researchers montfort university developed low cost low power intelligent camera system incorporates touchscreen fisheye lens capable capturing visual environment data performing algorithms extract metrics wirelessly transmit cloud analysis advantage short focal length wide field view fisheye camera system provide information multidisciplinary audience including image processing camera technology embedded systems support wide variety applications surveillance home monitoring motion analysis facial identification intelligent transportation systems paper describes first generation prototype camera system gathers luminance data capturing high dynamic range hdr imagery comparable data acquired costly cumbersome research equipment paper also explores requirements benefits challenges faced developing even smarter intelligent camera system
study investigated hiv related shame associated health related quality life hrqol older people living hiv plhiv structural equation modeling tested whether hiv related shame associated three dimensions hrqol physical emotional social well whether significant indirect associations hiv related shame three hrqol dimensions via depression loneliness sample plhiv years old results showed depression loneliness key mechanisms depression least partially accounting association hiv related shame emotional physical well respectively loneliness accounting association hiv related shame social well hiv related shame appears important correlate hrqol older plhiv may provide promising leveraging point improve hrqol older plhiv
paper summarizes research potential high resolution imagery downloaded google earth pro detect prehistoric canals hohokam period middle gila river valley arizona potential imagery identify obscured features evaluated means ground truthing reconnaissance well comparative analysis google earth imagery traditionally employed corona landsat etm imagery used analogous studies research presented method based solution utilize remote sensing exploratory archaeological research projects facing budget constraints conclusion research google earth imagery provided best spatial resolution detecting obscured irrigation features compared imagery used results investigation summarized potential research model applicable dryland settings
compact ghz doppler radar module developed paper non contact human vital sign detection ghz radar transceiver chip transmitting receiving antennas baseband circuits microcontroller bluetooth transmission module integrated implemented printed circuit board measurement range developed radar module successfully detect respiration heartbeat human adult
review summary objectives activities gastroenterological society australia given illustrates multidisciplinary multi functional roles society confident active supporting reflecting views members pursuit excellence clinical practice research education various areas digestive health
order reveal high velocity deformation mechanisms aluminum alloy sheets work compares dynamic plastic deformation behavior microstructure evolutions quasi static case scanning electron microscopy sem observations electron back scattering diffraction ebsd analysis transmission electron microscopy tem studies results show dynamic process exhibits different macro fracture shape much similar micro deformation pattern compared quasi static case conditions dislocation slip mechanism works deformation shock effect high velocity deformation much denser dislocations generated tendency cross slip dislocations increases dislocation bands narrow denser shown quasi static case much uniform dislocation configuration also exhibited dynamic loadings addition dynamic conditions existing pre strain introduce accommodated effect dynamically induced dislocations slight reduction density combining higher movement tendency characteristics multi slips homogenization effect dislocations dynamic conditions result much higher plasticity strength materials quasi static ones elsevier rights reserved
paper focused optimisation additive manufacturing process order obtained best quality surface minimum cost fit functional testing researches developed industrial innovative technologies laboratory manufacturing engineering department transilvania university brasov within pladetino platform innovative technological development interdisciplinary platform main purpose work demonstrate additive manufacturing technologies amt effectively applied assembly functional testing one popular amt used worldwide printing printing technologies divided following groups inkjet printing fused deposition modelling polymer jetting polyjet work focused applications polyjet technology
several behavioral models current active elements experimental purposes introduced paper models based commercially available devices suitable experimental tests current mixed mode filters oscillators circuits employing current mode active elements frequently used analog signal processing without necessity chip fabrication proper active element several methods electronic control intrinsic resistance proposed behavioral models discussed predictions theoretical assumptions supported simulations experiments contribution helps find cheaper effective way preliminary laboratory tests without expensive chip fabrication special active elements
like neurodegenerative diseases alzheimer disease prominent inflammatory component mediated brain microglia reducing microglial inflammation could potentially halt least slow neurodegenerative process major challenge development treatments targeting brain inflammation sheer complexity molecular mechanisms determine whether microglia become inflammatory take neuroprotective phenotype process highly multifactorial raising possibility multi target multi drug strategy could effective conventional monotherapy study takes computational approach finding combinations approved drugs potentially effective single drugs reducing microglial inflammation novel approach exploits distinct advantages two different computer programming languages one imperative declarative existing programs written languages implement model microglial behavior input output relationships programs agree data microglia extensive test battery imperative program used efficiently screen model efficacious combinations drugs declarative program used analyze detail mechanisms action efficacious combinations possible drug combinations simulated screen identifies able move simulated microglia least way neurotoxic neuroprotective phenotype subsequent analysis shows efficacious combinations stand superior strength reliability model offers many experimentally testable therapeutically relevant predictions concerning effective drug combinations mechanisms action
paper present different optimization techniques look table based algorithms double precision floating point arithmetic based analysis different look table based algorithms literature engineer basics blocks algorithms multiplier adder facilitate area timing benefits achieve higher performance propose different look table optimization techniques algorithms also analyze trade employing exact rounding ulp unit last place double precision floating point unit based performance extensibility criteria take algorithms proposed wong goto base case validate optimization techniques compare performance algorithms literature improve performance latency area wong goto division algorithm
introduction hereditary angioedema autosomal dominant primary immunodeficiency caused deficiency inhibitor protein characterized recurrent episodes subcutaneous mucosal edema unpredictable frequent crisis angioedema affect quality life individuals suffering kind disorder objective analyze clinical characteristics family index case hereditary angioedema determine impact disease quality life materials methods twenty six members family included trial analyzed complement antigenic functional inhibitor blood levels two instruments kidscreen used evaluate adult health quality children teenagers quality life respectively results eighty three percent individuals reporting symptoms condition exhibited serological criteria hereditary angioedema type low levels complement quantitative antigenic qualitative functional inhibitor relation patients psychological emotional performance quality life significantly affected symptoms hereditary angioedema conclusion study provides evidence first family valle aburra colombia characterized hereditary angioedema type despite use generic instrument negative impact quality life individuals suffering disease also confirmed
introduction crohn disease progressive inflammatory disease affecting entire gastrointestinal tract need definitive stoma considered ultimate phase damage often believed risk disease progression small performed aims goals study establish rate recurrence identify predictive factors recurrence time methods retrospectively reviewed medical records consecutive patients undergone collected clinical data diagnosis phenotype treatment surgery mortality stoma considered definitive restoration continuity possible due proctectomy rectitis anoperineal lesions apl fecal incontinence clinical recurrence defined need introduction intensification medical therapy surgical recurrence defined need new intestinal resection results eighty three patients males females median age years diagnosis included median time diagnosis years median follow years thirty five patients presented median time months patients presented median time months multivariate analysis apl colostomy time associated factors conclusion risk clinical recurrence high synonymous surgical recurrence especially patients apl colostomy
rabies virus rabv neurotropic virus causes serious disease humans animals worldwide reported different rabv strains result divergent prognoses animal model identify host factors affect different infection processes kinetic analysis host proteome alterations mouse brains infected different virulent rabv strains performed using isobaric tags relative absolute quantification itraq liquid chromatography tandem mass spectrometry proteomics approach analysis identified differentially expressed proteins deps pathogenic challenge virus standard cvs strain attenuated srv strain bioinformatics analyses deps revealed autophagy several pathways associated autophagy mammalian target rapamycin mtor signaling psk signaling nuclear factor erythroid related factor nrf mediated oxidative stress superoxide radical degradation dysregulated validation proteomic data showed attenuated srv induced autophagosome accumulation cvs vitro model findings provide new insights pathogenesis rabv encourage studies topic
study addressed moderating role classroom descriptive norms overt relational aggression social withdrawal prosocial behavior academic reputation association behavior social preference popularity early adolescence participants fifth grade students bar age years boys classrooms completed unlimited peer nominations status behavior classroom descriptive norms computed average proportion classroom nominations received different social behaviors multilevel analyses revealed negative association overt aggression social preference attenuated classrooms high norms overt aggression negative association academic reputation social preference enhanced classrooms high norms academic reputation classroom norms moderate associations behavior popularity type behavior type status considered examining classroom descriptive norms behavior status associations
farnesoid receptor fxr activation obeticholic acid oca demonstrated inhibit inflammation fibrosis development liver kidney intestine multiple disease models fxr activation also demonstrated suppress inflammatory response promote lung repair lung injury study investigated protective effects oca treatment day inflammation tissue remodeling fibrosis bleomycin induced pulmonary fibrosis rat model effects oca treatment morphological molecular alterations lung well remodeling alveoli right ventricle also evaluated lung function assessed measuring airway resistance inflation acute phase days bleomycin promoted initial thickening fibrosis lung interstitium upregulation genes related epithelial proliferation tissue remodeling hypoxia days evident increase deposition collagen lungs observed excessive deposition accompanied upregulation transcripts related extracellular matrix tgf snai snai indicating lung fibrosis administration oca protected bleomycin induced lung damage suppressing molecular mechanisms related epithelial tomesenchymal transition emt inflammation collagen deposition dose dependent reduction proinflammatory cytokines well tgf snail expression pirfenidone recently approved treatment idiopathic pulmonary fibrosis ipf significantly counteracted bleomycin induced pro fibrotic genes expression exert significant effects beta oca treatment bleomycin challenged rats also improved pulmonary function effectively normalizing airway resistance inflation lung stiffness vivo results oca similar even superior obtained pirfenidone conclusion results suggest important protective effect oca bleomycin induced lung fibrosis blunting critical mediators pathogenesis ipf elsevier ltd rights reserved
causes homelessness complex poorly understood paper describes homeless population santa clara county california terms adverse childhood events traumatic brain injuries tbis family breakdown respondents reported severely traumatic childhoods grew household person drug alcohol dependence endured psychological abuse child seventy six percent subjects recalled least one tbi loss consciousness nineteen percent foster care children reported someone parent primary caregiver fifty three percent felt moved much children experienced homelessness children santa clara county highest median income highest rate unsheltered homelessness nation leaders community members work together improve lives homeless prevent another generation homeless people
article investigates value adding practices manufacturing engineering integrated new product introduction model representing current practices align support lean integration manufacturing engineering defined results used identify novel set guiding principles integrated manufacturing engineering follows use data driven process build core capabilities develop standard deliver responsive processes align cross functional customer requirements investigation used mixed method approach comprises case studies identify current practice survey understand implementation sample component development projects within major aerospace manufacturer research contribution illustration aerospace manufacturing engineering practices new product introduction conclusions used indicate new priorities new product introduction cross functional interactions support flawless innovative new product introduction final principles validated series consultations experts sponsoring company ensure correct relevant content defined
alternatives hydraulic drives used board ship study italian navy order reduce use oil cause environmental problems high cost hydraulic system drive used onboard ship affected low efficiencies generally require intensive maintenance high encumbrance italian navy commissioned research project construction installation innovative oil free electric drive based permanent magnet linear actuator new electric motor efficient fault tolerant reduces encumbrance ensures greater control
digital image processing methods applied landsat data differentiate different natural land covers urban areas jizan red sea coast saudi arabia computer aided works combined field investigation confirm achieved results false color image bands rgb respectively found useful delineating sabkha non sabkha areas sabkha areas characterized hues light brown color non sabkha areas hues light grey light bluish color false color image bands clearly differentiates mangroves hues red color vegetation hues orange color principal component analysis pca image clearly shows wadi drainage estuary several shades green color coastal sabkha areas hues blue range light blue denoting dry sabkha dark blue denoting wet sabkha sand dunes shown fuchsia color results study identify features urban populated areas land vegetation moisture intensity sediments shallow deep waters reef islands sabkha non sabkha areas salt dome shores tidal flats wadi drainage mangrove habitat width shallow seawater land seawater contacts several maps produced study showing distribution abovementioned features maps useful base reference studies geologists engineering geologists hydrogeologists governmental decision leaders
method analyzing coupled wind vehicle bridge system proposed also considers shielding effect bridge tower triangular wind barriers static wind load buffeting wind load bridge vehicle included shielding effects bridge tower triangular wind barriers incorporated taking surface integral wind load inter history iteration adopted solve vehicle bridge dynamic equations time varying external loads results show installing triangular wind barriers area bridge tower bridge response vehicle safety factors change slightly peak value train car body acceleration significantly reduced wind barrier size increased
objectiveto evaluate whether extent skin redness erythema affects investigator blinding transcranial direct current stimulation tdcs trials material methodstwenty six volunteers received sham active tdcs applied saline soaked sponges different thicknesses high resolution skin images taken min stimulation randomized presented experienced raters evaluated erythema intensity judged likelihood stimulation condition sham active addition semi automated image processing generated probability heatmaps surface area coverage erythema adverse events also collected resultserythema present less intense sham compared active groups erythema intensity inversely directly associated correct sham active stimulation group allocation respectively image analyses found erythema also occurs sham distribution homogenous electrodes tingling frequency higher using thin compared thick sponges whereas erythema intense thick sponges conclusionsoptimal investigator blinding achieved erythema tdcs mild erythema distribution electrode patchy occurs sham tdcs varies according sponge thickness discuss methods address skin erythema related tdcs unblinding
interventions manage weight stress interconception period time immediately following childbirth subsequent pregnancy needed promote optimal maternal infant health outcomes address gap summarize current state knowledge critically evaluate research focused weight stress management interconception period provide future recommendations research area evidence supports importance weight stress management reproductive years impact weight maternal child health outcomes however evidence based treatment models address postpartum weight loss manage maternal stress interconception period lacking problem compounded inconsistent definitions measurements stress recommendations future research include interventions address weight stress tailored women interconception period interventions address healthcare providers understanding significance weight stress management interconception long term follow studies focus public health implications weight stress management interconception addressing obesity stress interconception period via reproductive lens starting point women families live long healthy lives
develop theoretical model security investments network interconnected agents network connections introduce possibility cascading failures due exogenous endogenous attack depending profile security investments agents provide tractable decomposition individual payoffs effect externality also enables characterize individual investment incentives recursively considering network one agent removed time using decomposition provide characterization equilibrium socially optimal investment levels function structure network highlighting role new set network centrality measures shaping levels equilibrium optimal investments attack location endogenized assuming attacker chooses probability distribution location attack order maximize damage similar forces still operate greater investment agent shifts attack parts network equilibrium may involve much investment relative social optimum elsevier inc rights reserved
article elaborates evaluation seven software requirements prioritization methods anp binary search tree ahp hierarchy ahp spanning tree matrix priority group bubble sort based case study local project automation mobilink franchise system experiment conducted students requirement engineering course department software engineering university science technology bannu khyber pakhtunkhawa pakistan parameters measures used experiment consistency indication scale measurement interdependence required number decisions total time consumption time consumption per decision ease use reliability results fault tolerance requirements prioritization techniques evaluated results experiment show anp successful prioritization methodology among available prioritization methodologies
novel stray insensitive realisation switched capacitor filters presented factored state space representation provides means implementing orthogonal filter structures good sensitivity properties factored state space realisation represented regular signal flow graph switched capacitor realisations basic sections signal flow graph proposed four phase implementation provides stray insensitive switched capacitor realisation design example illustrates application novel approach
background intentional relationship model specifically focused relational aspect therapy model describes six therapeutic modes represent different types interaction therapist however preferences therapeutic mode use researched aims study aims describe preferences therapeutic modes undergraduate occupational therapy students well explore factors associated therapeutic modes methods sample occupational therapy students based two different norwegian universities participated study completed norwegian self assessment modes questionnaire along sociodemographic information descriptive analysis bivariate correlation linear regression analysis employed results problem solving mode frequently endorsed generally weak associations variables female sex student education program trondheim associated higher preference collaboration conclusion diversity students preferences modes problem solving mode preferred students need aware mode feel comfortable make sure use modes fit specific client significance occupational therapy education programs need incorporate raising awareness therapeutic modes
inflammatory bowel disease ibd general term describe inflammatory diseases gastrointestinal tract crohn disease ulcerative colitis ibd affects approximately individuals exerts significant health quality life burden patients surgical intervention curative ulcerative colitis currently cure crohn disease since case fact patients often diagnosed young age ibd exerts significant financial burden health care system society whole underlying pathology ibd complex involves combination genetic environmental microbial factors regardless underlying causes condition disease universally characterized disruption protective epithelial barrier separating intestinal lumen mucosal immune system barrier becomes compromised sequence events ensues occur repetitive cycles ensure long term serious damage gut role hypoxia hypoxia dependent signalling pathways increasingly appreciated play role physiology pathophysiology intestine intestinal epithelium normally exists state physiological hypoxia additional tissue hypoxia feature active inflammatory disease furthermore recent pre clinical animal studies clearly supported rationale pharmacologically manipulating oxygen sensitive hypoxia inducible factor hif pathway models ibd thus review discuss contribution hypoxia sensitive pathways pathology ibd finally discuss emerging evidence manipulation hypoxia sensitive pathways treatment ibd institut pasteur published elsevier masson sas rights reserved
background balloon aortic valvuloplasty bav resurging bridge treatment patients severe aortic stenosis dissemination transcatheter aortic valve implantation however significantly high periprocedural mortality complication rates still limit indications bav efforts needed improve safety efficacy bav methods results retrospectively investigated safety efficacy simultaneous biplane mode dimensional transesophageal echocardiography biplane tee guided antegrade transseptal multiple inflation bav gradual upsizing balloon enrolling consecutive patients underwent bav median age years male patients clinical frailty scale society thoracic surgeon score balloon inflated median times improved mean aortic valve pressure gradient mmhg safely performed bav patients without periprocedural death symptomatic stroke although asymptomatic stroke detected patients diffusion weighted magnetic resonance imaging kaplan meier estimates showed survival rate cardiovascular death free survival year conclusions biplane tee guided antegrade multiple inflation bav might potential improve periprocedural survival without increasing complications compared conventional retrograde bav patients severe
objectives aim present study evaluate geriatric outpatient sample frail scale investigate psychometric properties scale characterize different associations subdimensions scale demographic clinical data design cross sectional observational study setting geriatric outpatient center university based hospital sao paulo brazil participants total men women aged years older evaluated march september measurements translated version frail scale used evaluate frailty review socio demographic data medical records medication laboratory data conducted multivariate ordinal logistic regression model used investigate association frailty categories clinical variables exploratory factor analysis parameter logistic item response theory used evaluate psychometric properties frail scale results sample distributed robust prefrail frail older adults participants reported fatigue frailty associated older age depression dementia number medications taken factor model frail scale ambulation resistance namely physical performance fatigue weight loss illnesses namely health status provided independent classifications frailty status physical performance ambulation resistance strongly associated higher age dementia whereas health status fatigue weight loss illnesses associated female sex depression conclusions results suggest existence subdimensions scale suggesting different pathways frailty frailty associated older age depression dementia number medications outpatient sample amda society post acute long term care medicine
benefit using stone columns low strength soil proved efficient method improve load carrying characteristics shallow footings stone column bearing capacity mainly depends circumferential confinement providing native soft soils paper large body laboratory tests performed stone columns diameters length diameter unreinforced encased geotextile reinforced stone columns tested vertical encased stone column vesc considered investigate effect reinforcement footing load carrying characteristics main objective research compare effectiveness vertical encapsulating stone columns conditions various stone column diameters addition tests groups stone columns diameter carried investigate effect presence neighboring columns reference loaded stone column results show stone column bearing capacity increases using vertical reinforcing material increasing length strength reinforcement vesc stone column bearing capacity increases addition stress concentration ratio columns also increases moreover lateral bulging decreases using geotextiles numerical analysis based finite element method fem also conducted study scale effects small stone columns tested expand reinforcement effectiveness large reinforced stone columns elsevier ltd rights reserved
art quantum algorithm design highly nontrivial grover search algorithm constitutes masterpiece quantum computational software article use methods geometric algebra information geometry enhance algebraic efficiency geometrical significance digital analog representations grover algorithm respectively specifically used describe grover iterate discretized iterative procedure exploits quantum interference amplify probability amplitude target state measuring query register transition digital analog descriptions occurs via stone theorem relates unitary grover iterate suitable hermitian hamiltonian controls schrodinger quantum mechanical evolution quantum state towards target state discrete continuos transition completed used interpret grover iterative procedure geodesic path manifold parametric density operators pure quantum states constructed continuous approximation parametric quantum output state grover algorithm finally discuss dissipationless nature quantum computing recover quadratic speedup relation identify superfluity walsh hadamard operation perspective emphasis statistical mechanical considerations elsevier rights reserved
data national survey children health national survey children nonparental care used fit multinomial logistic model comparing three groups never considered adoption ever considered currently planning adoption planning adoption adopted adoption may likely caregiver non kin foster parent foster care agency involved financial assistance available plans adopt adopted may face adoption barriers extreme poverty lower education unmarried
interdiscipline wireless communication control engineering periodical charging issue wireless rechargeable sensor networks wrsns popular research problem however existing techniques periodical charging neglect focus location relationship topological feature leading large charging times long traveling time paper develop hybrid clustering charging algorithm hcca firstly constructs network backbone based minimum connected dominating set built given network next hierarchical clustering algorithm takes advantage location relationship proposed group nodes clusters afterward means clustering algorithm implemented calculate energy core set realizing energy awareness optimize performance hcca hcca proposed transform energy charging process task splitting model tasks generated hcca split small tasks aim reducing charging time enhance charging efficiency last simulations carried demonstrate merit schemes simulation results indicate hcca enhance performance terms reducing charging times journey time average charging time simultaneously moreover hcca improve performance hcca elsevier inc rights reserved
work develops method calibrating crystal plasticity model results discrete dislocation simulations crystal model explicitly represents junction formation annihilation mechanisms applies mechanisms describe hardening hexagonal close packed metals model treats dislocation mechanisms separately elastic interactions among populations dislocations model represents conventional strength interaction matrix split elastic interactions junction formation mechanisms accurately reproduces data results multi scale model better represents lower scale physics fitting procedure employs concepts machine learning feature selection regularized regression crossvalidation develop robust physically accurate crystal model work also presents method ensuring final calibrated crystal model respects physical symmetries crystal system calibrating crystal model requires fitting two linear operators one describing elastic dislocation interactions another describing junction formation annihilation dislocation reactions structure operators final calibrated model reflect crystal symmetry slip system geometry simulations
series novel ferulic acid alkylamines derivatives designed synthesized evaluated multitarget directed ligands alzheimer disease vitro studies displayed synthesized target compounds showed impressive inhibitory activity butyrylcholinesterase buche significant inhibition disaggregation self induced beta amyloid beta aggregation acted potential antioxidants particularly compound one potent buche inhibitor value equine serum buche ratbuche human serum buche found good acetylcholinesterase ache inhibitor electric eel ache ratache human erythrocytes ache result molecular docking provided explanation selective buche inhibitory activity compound also noteworthy inhibitory effects selfinduced beta aggregation found disaggregate self nduced beta aggregation elucidated transmission electron microscopy meanwhile compound showed modest antioxidant activity trolox good protective effect induced cell injury low toxicity moreover compound could cross blood brain barrier bbb vitro significantly compound exhibit acute toxicity mice doses step passive avoidance test showed compound significantly reversed scopolamine induced memory deficit mice taken together results indicated compound promising multifunctional agent treatment alzheimer disease particularly advanced stages elsevier masson sas rights reserved
article introduced system structure imaging principle three dimensional imaging laser radar paper used xckt xilinx chip kintex series used temporal interpolation method measure distance rough side used pll multiplier mhz reached time accuracy method used thin chip delay chains carry resources reach accuracy greatly improved accuracy timing imaging application technique used delay line apd array imaging system channel distance accuracy greatly improved echo signal photoelectric conversion completed apd array detector designed impedance amplifier analog signal processing circuit fpga signal processing circuit complete back end processing timing function fpga array timer clock achieve coarse portion timing delay line technique measuring length time non integer multiple period laser pulse emission moment reception stage delay units delay accuracy sub magnitude achieve precision measuring part timers device close imaging experiments obtaining pixel imaging test results presented improve system accuracy improved method
paper describes control computations distributed computing environment dce basis meta monitoring simulation modeling computations controlled multiagent system given organizational structure resource allocation carried agents use economic mechanisms controlling supply demand controlling actions agents formed basis simulation modeling functional processes dce data dce resources processes collected emergency situations dce nodes detected prevented meta monitoring system environment research results techniques selecting control actions methods intellectual processing effective storage data
formula car state art hybrid electric vehicle power unit composed turbocharged gasoline engine two electric motor generator units connected traction system turbocharger powertrain offers additional degree freedom therefore requires energy management system supervisory controller significant influence vehicle fuel consumption achievable lap time therefore thorough systematic optimization energy management system crucial prerequisite win race complexity system strict regulations make time optimal energy management problem non trivial solve effective implementation solution car difficult achieve ebbesen salazar convex numerical solver designed optimal strategies derived analytically using non smooth version pontryagin minimum principle respectively building results design nonlinear program tune efficient version optimal control policy order precisely match various boundary conditions fuel consumption battery usage allows simple robust implementation time optimal control strategies vehicle guarantees compatibility fia rules simulator used test obtained feedforward controls one race lap barcelona results stand comparison optimal solutions obtained numerical solver validate effectiveness strategy ifac international federation automatic control hosting elsevier ltd rights reserved
background context lumbar fusion common costly procedure united states reimbursement surgical procedures increasingly tied care quality patient safety part value based reimbursement programs incidence adverse quality events among lumbar fusion patients unknown using definition care quality patient safety indicators psi used centers medicare medicaid services cms association insurance status incidence psi similarly unknown lumbar fusion patients purpose study sought determine incidence psi patients undergoing inpatient lumbar fusion quantify association primary payer status psi population study design retrospective cohort study carried patient sample sample comprised adult patients aged years older included nationwide inpatient sample nis underwent lumbar fusion outcome measure incidence one psi validated widely used metric inpatient health care quality patient safety primary outcome variable methods nis data examined cases inpatient lumbar fusion incidence adverse patient safety events psi determined using publicly available lists international classification diseases ninth revision clinical modification diagnosis codes logistic regression models used determine association primary payer status medicaid self pay relative private insurance incidence psi results total adult lumbar fusion procedures recorded nis patients excluded secondary analysis missing listed primary insurance status national incidence psi calculated per patient years observation approximately secondary analysis adjusting patient demographics hospital characteristics medicaid self pay patients significantly greater odds experiencing one psi inpatient episode relative privately insured patients odds ratio confidence interval conclusions among patients undergoing inpatient lumbar fusion insurance status associated adverse health care quality events used determine hospital reimbursement cms source disparity must studied improve quality care delivered vulnerable patient populations elsevier inc rights reserved
braille character recognition one foundational skills required teachers braille prior research evaluated computer programming teaching braille print letter relations scheithauer tiger current study developed program visual braille trainer teach letters also numerals punctuation symbols contractions evaluated program sighted undergraduate participants exposure program resulted mastery braille print relations participant
paper presents analytical calculus long rectangle plate embedded one lengths concentrated load middle uniform load surface using transfer matrix method according strength materials hypotheses method consists discrediting length plate parts unit part beam transfer matrix plate links state vectors left side right side conditions hearings calculate state vector origin general expression deformation
new full precision algorithm solve debye scattering equation developed high performance computing powder diffraction line profiles large scale atomistic models nanomaterials debye function evaluated using pair distribution function computed high accuracy exploiting series expansion error calculated equispace sampled pair distances atoms intensity uncertainty standard deviation computed diffraction profile estimated function algorithm intrinsic approximations coordinate precision atomic positions confirming high accuracy simulated pattern based propagation uncertainty new algorithm provides accurate powder diffraction profile brute force calculation indeed precision floating point numbers employed brute force computations worse estimated accuracy provided new algorithm software application rose implemented parallel computing cpu gpu multi core processors distributed clusters computing performance directly proportional total processor speed devices average speed similar computed pair distances per second measured allowing simulation powder diffraction pattern similar million atom microstructure couple hours moreover pair distribution function recorded reused evaluate powder diffraction profiles system different properties rather theta range step wavelength avoiding additional pair distance computations approach used investigate large collection monoatomic polyatomic microstructures isolating contribution atoms belonging different moieties different species crystalline domains
traditional allergological diagnostics often provide laboratory data seem correspond similar positive results different patients however technological developments introduction molecular diagnostics possible extract highlight differences serological laboratory data obtain detailed specificity various allergen components different clinical settings allergological diagnostics prove increasingly useful accurately distinguishing cross reactivity cosensitization aspect important especially patients traditional diagnosis polysensitized molecular diagnosis allergology expanded range applications thanks ability ige dose specific addition classic total ige serum allergens food inhalants also individual protein components make allergenic source essential establish correct diagnosis order determine appropriate therapy therefore crucial discern whether patient truly allergic presents specific ige molecules species positivity given structural homology different proteins molecular diagnostics emerges valuable tool discrimination allergic patients differentiate true allergies cross reactivity molecular diagnostics used targeted manner accurate assessment diagnosis would also reduce use oral challenges predict severe reactions allergy persistence
medical ultrasonic imaging utilized variety clinical diagnoses many years recently needs portable mobile medical ultrasonic diagnoses development real time medical ultrasonic imaging algorithms embedded computing platforms rising research direction typically delay sum beamforming algorithm implemented embedded medical ultrasonic scanners algorithm easiest implement real time frame rate image quality algorithm high enough complicated diagnostic cases result minimum variance adaptive beamforming algorithm medical ultrasonic imaging considered paper shows much higher image quality delay sum beamforming algorithm however minimumvariance adaptive beamforming algorithm complicated algorithm computational complexity consequently easy implement algorithm embedded computing platform real time frame rate hand gpu well known parallel computing platform image processing therefore embedded gpu computing platform considered potential real time implementation platform minimum variance beamforming algorithm paper applying described effective implementation strategies gpu implementation minimum variance beamforming algorithm performed times faster arm implementation heterogeneous embedded platform furthermore platform power consumptions computation energy efficiency platform cost efficiency experimental heterogeneous embedded platforms also evaluated demonstrated investigated heterogeneous embedded computing platforms suitable real time portable mobile high quality medical ultrasonic imaging device constructions
current antipsychotic medications fail satisfactorily reduce negative cognitive symptoms produce many unwanted side effects necessitating development new compounds cross species experimental behavioural model systems valuable inform development drugs aim current study test hypothesis controlled sleep deprivation safe effective model system psychosis combined oculomotor biomarkers schizophrenia using randomized counterbalanced within subjects design investigated effects night total sleep deprivation healthy participants smooth pursuit eye movements spem prosaccades antisaccades self ratings psychosis like states compared normal sleep control night sleep deprivation associated reduced spem velocity gain higher saccadic frequency elevated spatial error increase direction errors sleep deprivation also increased intra individual variability spem measures addition sleep deprivation induced psychosis like experiences mimicking hallucinations cognitive disorganization negative symptoms turn moderate associations direction errors taken together sleep deprivation resulted psychosis like impairments spem performance however diverging somewhat schizophrenia literature sleep deprivation additionally disrupted control sleep deprivation thus represents promising possibly unspecific experimental model may helpful improve understanding underlying mechanisms pathophysiology psychosis aid development antipsychotic pro cognitive drugs
introduction hereditary angioedema due inhibitor deficiency inh hae type dysfunction inh hae type rare disease characterized recurrent episodes edema estimated frequency global population without racial gender differences study present results nationwide survey inh hae patients referring italian centers italian network inh hae itaca methods italian patients diagnosed inh hae included study diagnosis inh hae based family personal history recurrent angioedema without urticaria antigenic functional inh deficiency results patients female unrelated families included survey since patients diagnosed inh hae died data patients missing analysis performed accordingly minimum prevalence hae italy inhabitants equivalent compared general population patients less represented early late decades life men start reducing decade women median age patients median age diagnosis years inh hae type median age diagnosis type median age diagnosis functional cinh patients antigen cinh type parameter therefore considered initial screening differential diagnosis angioedema
background aimed compare acceptability levonorgestrel yuzpe regimen among iranian women based side effects resulting changes amount pattern menses methods five hundred twenty nine participants aged regular menses one act unprotected intercourse within included double blind controlled trial randomly assigned lng groups receiving levonorgestrel given apart ethinyl estradiol plus levonorgestrel repeated respectively results participants receiving levonorgestrel experienced significantly lower side effects case nausea vomiting dizziness significant difference observed efficiencies treatments conclusion significantly lower side effects levonorgestrel considered greater acceptability translated higher efficiency
attempts made improve mechanical design using nonlinearity rather eliminating especially area vibration control energy harvesting systems need predict dynamic behavior estimate system properties measurements paper concerns experimental investigation simple identification method specific systems behavior known similar duffing type system involves measurement jump frequencies amplitudes displacement frequencies theoretical basis method briefly described experimental investigation beam shaker system results comparable determined restoring force surface method method described article advantage data collected processed easily restoring force surface method potentially suitable engineering community existing identification measures
field emotion understanding replete measures yet lacks integrated conceptual organizing structure identify organize skills associated recognition knowledge emotions highlight focus emotion understanding localized self specific others generalized others introduce conceptual framework emotion understanding recognition knowledge abilities eureka categorize existing methods emotion understanding within framework highlight current gaps future opportunities assessing emotion understanding across lifespan hope eureka model provides systematic integrated framework conceptualizing measuring emotion understanding future research
nowadays due rapid changes developments business life becomes increasingly complex yields many employees lots works together limited time result time pressure job stress negatively affect employee productivity context study examined health sector one today complex sectors success health manpower important element quality health services manner working environment qualified less troublesome health staff patients receive better qualified health services health sector complex industry services provided also different characteristics employees working sector continuously working time pressure concerning human life expose health sector employee high stress experiencing excessive stress adversely affect performance success managements educate employees time management effort cause less stress help jobs effectively study theoretical study domestic foreign literature subject studied detail subsequent studies literature supported field work
paper method automatic tuning fractional pid controller proposed fractional pid controller contains non integer integrations derivatives
ion exchange polymer metal composites known type electro active smart material complex mechanism takes nonlinear characteristic blocks development utilization paper new model electro active smart actuator based non integer order models proposed experimental setup realized study electro active smart actuator non integer behavior algorithm based marquardt least squares recursive identification developed order identify fractional order model electro active smart actuator fractional order simulation model designed comparing integer order model simulation results demonstrate behavior fractional order model much better integer order model fractional order model electro active smart actuator achieve better performance
introduction pathogenesis inflammatory bowel diseases ibd multifactorial interactions genetic environmental factors despite existence genetic factors largely demonstrated epidemiological data several genetic studies findings useful term disease prediction disease progression targeting therapy areas covered review summarizes results genome wide association studies crohn disease role epigenetics recent discovery genetic studies new pathogenetic pathways furthermore focuses importance applying genetic data clinical practice specifically better target therapy predict potential drug related toxicity expert opinion genetic markers identified crohn disease allowed investigators hypothesize cases prove usefulness new specific therapeutic agents however heterogeneity complexity disease far limited daily clinical use genetic information finally study implications genetics therapy either predict efficacy avoid toxicity considered still infancy
ethiopian government working rainwater harvesting rwh three decades despite efforts results expected different barriers posed challenges promoting rwh ethiopia study done identify main problems obstacles reflect potential solutions result absence clear policy definitions lack sustainably implemented projects poor societal perceptions rwh local professionals lacking proper knowledge initial investment costs found major causes poor outcomes considering site specific nature water issues authors propose various management strategies policy oriented promotion formulation design guidelines proactive planning collaborative research integration rwh cost covering practices
doped thin films various contents successfully deposited aqueous sol gel method followed post annealing process derived thin films characterized ray diffraction raman spectra scanning electron microscopy atomic force microscopy besides resistance temperature relationship infrared emissivity waveband analyzed effects doping thermochromic properties thin films studied results show atoms enter crystal lattice transition temperature decreases gradually increasing doping amount emissivity thin films dropped real temperature degrees thermal infrared images also examined different temperature thermal imager results indicate temperature doped thin films begin lower emissivity decreases gradually increasing doping amount doped thin films control infrared radiation intensity actively lower temperature level degrees great application prospects adaptive infrared stealth technology elsevier rights reserved
glucosylceramide gccer various effects skin moisturizing improvement atopic dermatitis enhancement skin barrier function however mechanism glccer skin barrier function remains unclear study effect gccer pineapples glccer dry skin protection intestinal immunity investigated using hairless mice fed special diet vitro culture model consisting intestinal epithelial caco macrophage raw oral administration glccer showed improvement skin barrier function enhancement interleukin mrna expression small intestine expression lps stimulated raw cells enhanced purified glccer glccer furthermore pretreatment caco beta glucocere brosid ase ceramidase inhibitor suppressed enhancement expression sphingosine kinase inhibitor demonstrated giccer intestinal metabolite sphingadienine ameliorated dry skin symptoms elsevier ltd rights reserved
objective several molecules involved pathogenesis new bone formation ankylosing spondylitis aim present study evaluate serum levels semaphorin investigate correlations radiographic damage disease activity function treatment methods patients fulfilled modified new york criteria enrolled study healthy subjects also enrolled control group basdai asdas crp basmi basfi patients physician vas reactive protein erythrocyte sedimentation rate evaluated baseline visit radiographs spine pelvis performed within six months enrolment study collected patients spinal damage assessed using msasss serum concentrations semaphorina assessed baseline four months therapy patients started anti tnf results twenty healthy subjects forty patients enrolled study patients started anti tnf therapy day baseline visit semaphorina serum concentrations median similar patients controls significant correlation found semaphorin serum levels radiographic damage index semaphorin serum levels positively correlated esr values rho disease activity assessed physician vas rho differences found semaphorina serum levels months compared baseline values conclusion results present study could contribute intriguing topic bone remodelling
objective previous research shows migraine general headache symptoms increase traumatic events questions remain whether posttraumatic stress disorder ptsd produces migraine headache symptoms individuals afflicted migraine headache especially likely develop ptsd test whether ptsd symptoms following natural disaster associated higher odds reporting frequent headaches migraines postdisaster decompose ptsd intrusion avoidance hyperarousal symptom clusters examine uniquely related headache migraine postdisaster method use prospectively collected pre postdisaster data explore whether overall ptsd symptoms symptom clusters associated migraine headache sample hurricane katrina survivors account severity hurricane exposure control baseline migraine headache problems reduce probability heightened ptsd susceptibility among already suffered conditions could explain observed associations results ptsd symptoms associated higher odds experiencing frequent headaches migraines standard deviation change ptsd score corresponding twice odds confidence interval trouble frequent headaches migraines post katrina period additional point intrusion subscale sample associated higher odds reporting frequent headache migraine confidence interval found association avoidance hyperarousal symptoms conclusions clinicians disaster planners aware disaster survivors might heightened risk migraine headache episodes experiencing intrusive reminders may affected
performance compacted clay liners commonly used landfill barrier systems subject decline terms hydraulic conductivity left exposed atmospheric conditions extended period time prior placement overlaying layers resulting desiccation cracking lead increased hydraulic conductivity desiccation crack intensity studied three clayey soils commonly used construction landfill barrier system relatively large scale test setup exposed real time atmospheric conditions complete annual cycle white separator geotextile cover presumed capable reducing intensity desiccation cracking absorbing maintaining higher amounts moisture reducing temperature soil surface comparison directly exposed soil surface desiccation cracking monitored using digital imaging technique three compacted clay liners two sets one open air second covered white geotextile crack intensity factor approached relatively stable phase certain cycles corresponding atmospheric dry wet cycles results indicated white separator geotextile capable reducing crack intensity factor throughout experiment including cyclic phase desiccation cracking stable phase maximum reduction crack intensity factor result applying geotextile cover observed soil lowest plastic index clay content therefore lowest magnitude crack intensity factor two soils similar clay content different plastic index showed reductions crack intensity factor cyclic phase covered geotextile elsevier ltd rights reserved
severe poorly controlled asthma still accounts great portion patients affected disease control future risk management identified international guidelines main goals patients asthma need new treatment approaches led reconsider anticholinergic drugs option asthma treatment tiotropium first anticholinergic drug approved children adults poorly controlled asthma currently considered option steps global initiative asthma large randomized clinical trials enrolling patients moderate severe asthma add therapy tiotropium demonstrated efficacious improving lung function decreasing risk exacerbation slowing worsening disease accordingly tiotropium demonstrated non inferior compared long acting beta agonists maintenance treatment along medium high inhaled corticosteroids view numerous ancillary effects acting inflammation airway remodeling mucus production cough reflex along good safety profile broad spectrum efficacy demonstrated different disease phenotypes tiotropium represent beneficial alternative therapeutic management poorly controlled asthma present extensive narrative review presents pharmacological pathophysiological basis guided rationale introduction tiotropium asthma treatment algorithm particular focus conventional unconventional effects finally data tiotropium efficacy safety recent randomized clinical trials performed age categories extensively discussed
background persistent low grade immune inflammatory processes oxidative nitrosative stress hypothalamic pituitary adrenal axis activation integral pathophysiology major depressive disorder mdd microbiome intestinal compositional changes resultant bacterial translocation add new element bidirectional interactions gut brain axis new evidence implicates pathways patho aetiology mdd addition abnormalities gut brain axis associated several chronic non communicable disorders frequently occur individuals mdd including limited irritable bowel syndrome ibs chronic fatigue syndrome cfs obesity type diabetes mellitus tdm methods searched pubmed medline database may studies investigated intestinal dysbiosis bacterial translocation leaky gut pathophysiology mdd occurring somatic comorbidities emphasis ibs cfs obesity tdm results composition gut microbiota influenced several genetic environmental factors diet several lines evidence indicate gut microbiotadiet interactions play significant pathophysiological role mdd related medical comorbidities gut dysbiosis leaky gut may influence several pathways implicated biology mdd including limited immune activation neuroplasticity cascades however methodological inconsistencies limitations limit comparisons across studies conclusions intestinal dysbiosis leaky gut may constitute key pathophysiological link mdd medical comorbidities emerging literature opens relevant preventative therapeutic perspectives karger basel
anorexia nervosa atypical form malnutrition peculiar changes immune system hypothesized different lymphocyte subsets differentially affected malnutrition thus aim investigate influence body mass loss variability lymphocyte subsets patients group adolescent female patients aged years referred first episode either feeding eating disorders elsewhere classified studied upon admission restricting subtype binge purging subtype feeding eating disorders elsewhere classified ninety healthy adolescents served controls white blood cells lymphocyte subsets analyzed flow cytometry relationships body mass index bmi score assessed linear models adjusted diagnostic subtype age leukocyte numbers lower patients controls relative lymphocytosis observed restricting subtype lower memory counts found eating disorder patients compared controls differences found counts naive memory subsets groups negative associations lymphocyte percentage bmi score well cell counts naive percentage counts bmi score found conclusion increased naive lymphocyte subsets associated body mass loss drive relative lymphocytosis observed patients reflects adaptive mechanism preserve adaptive immune response elsevier inc rights reserved
study investigated individuals work family enrichment wfe crosses affect partners marital satisfaction well spills affect marital satisfaction sample chinese dual earner couples drawing conservation resources cor theory broaden build theory person perception literature examined social support social undermining underlying mechanisms responsible transmission processes structural equation modeling analyses showed crossover associations husbands wfe related wives marital satisfaction wives perceptions increased social support whereas wives wfe related husbands marital satisfaction husbands perceptions decreased social undermining spillover associations husbands wfe related marital satisfaction perceiving social support partners whereas wives wfe related marital satisfaction perceiving social support well less social undermining partners findings add literature examining transmission positive experiences marital partners varied patterns social interaction well highlighting perceptions partner behaviors relevant mechanism explain transmission work marriage within individual
laparoscopic sleeve gastrectomy lsg become one popular bariatric surgeries worldwide given good result concerning weight loss long term morbidity surgical technique well standardized specimen extraction still matter controversy surgeons video present simple fast safe reproducible technique specimen extraction laparoscopic sleeve gastrectomy sleeve gastrectomy completed hemostasis specimen introduced retrieval bag stomach specimen orientation important largest specimen part removed firstly held fundus introduced direct vision trocar traction applied simultaneously remove trocar cord bag grasper stomach held kocher outside peritoneal cavity bag opened everted protect wound pneumoperitoneum deflated relax abdominal wall specimen removed abdominal cavity traction hand hand grasping gauze applied technique consecutive patients average body mass index first postoperative visit month none patients experienced wound infection clinical incisional hernia detected one patient hand hand grasping gauze technique simple safe reproducible time saving
aim alzheimer disease patients increasing rapidly every year scholars tend use computer vision methods develop automatic diagnosis system background gorji proposed novel method using pseudo zernike moment tested four classifiers learning vector quantization neural network pattern recognition neural network trained levenberg marquardt resilient backpropagation scaled conjugate gradient method study presents improved method introducing relatively new classifier linear regression classification method selects one axial slice brain image employed pseudo zernike moment maximum order extract features image finally linear regression classification harnessed classifier results proposed approach obtains accuracy sensitivity specificity conclusion method performs better gorji approach five state art approaches therefore used detect alzheimer disease
ethnopharmacological relevance erxian decoction exd empirical chinese medicine formula effectively used clinical treatment menopause related symptoms china previous data group show exd steroidogenic effect natural menopausal sprague dawley rats rats animal model menopause however mechanistic studies steroidogenic effects exd still inadequate hence mechanisms steroidogenic effects exd studied vitro vivo study materials methods menopause causes decline endocrine function series symptoms study month old female rats low serum estradiol level employed endocrine functions treatment exd assessed determination serum estradiol level proteins involved steroidogenic pathway including star beta hsd beta hsd aromatase activation phosphorylated protein kinase akt pkb well estradiol receptor proteins alpha beta exd treatment analyzed kinase inhibition assay conducted confirm mechanism steroidogenic effects exd vitro mcf cells used investigate whether exd stimulated breast cancer cell proliferation results results revealed significantly ameliorated serum estradiol level significantly increased expression ovarian aromatase pkb exd treated rats exd attenuated beta estradiol stimulated proliferation breast cancer cells conclusions results obtained immunoblotting measurements serum estradiol level present investigation revealed exd may relieve menopausal syndrome upregulation ovarian aromatase pkb expression without stimulating growth breast cancer cells
despite significant attention gained three dimensional printing technology many research fields yet found application tyre road friction pavement engineering better understand impact different roughness length scales rubber friction feasibility utilising printing replicating pavement texture strength technology creating customised roughness patterns investigated image stitching algorithm developed common portable optical profiler order obtain large topography asphalt specimen friction experiments printed topography showed replication efficacy wavelength printed samples artificial surface patterns generated random process theory fractal modelling rubber sliding tests implied different frictional behaviour asphalt specimen printed replica mainly attributed severe wear rubber rougher asphalt specimen artificial geometries friction increased hurst exponent increased results also suggested reducing roll wavevector increasing maximum aggregate size reduces friction coefficient fractal surface
intrusion detection systems firewalls security devices provide guarantee safe operation network wide application network virus hackers security incidents increasing security devices send tens thousands warning short period time network management personnel difficult find useful information massive alarms addition increasingly large scale network mobile network data management data related sms mms message service system single security device detect intrusions must consider make equipments work harmoniously paper based problems mobile data network security integrated management system studied research implementation security event management mechanism discussed detail event management proposed paper regarded extension concept network management enriches content five functions network management addition traditional network management system management two independent concepts two management systems combined together event management network security operation improved purpose security event modeling format events different event sources facilitate subsequent processing paper object oriented modeling method adopted scalable time difference kinds events fully considered description model paper uses xml language universal harm computer virus network security management big characteristics computer virus typical symptoms harmfulness analyzed security mobile communication network analyzed proposed system modification virus prevention implementation general security management system mobile data network focus article mainly three aspects audit log management security event monitor account password management mobile data network involving multiple business systems implementation integrated security management system paper adopt rule based hierarchical system architecture coupling degree module relatively loose great flexibility deployment authors published elsevier ltd
cystic fibrosis often associated intestinal inflammation due several factors including altered gut microbiota composition study analyzed fecal microbiota among patients cystic fibrosis years age compared findings age matched healthy subjects participating patients included homozygotes heterozygotes delf mutation heterozygotes presenting non delf mutations used pcr dgge qpcr analyze presence bacteria archaea sulfate reducing bacteria overall findings confirmed disruption cystic fibrosis gut microbiota principal component analysis qpcr data revealed differences homozygotes heterozygotes groups distinct healthy subjects showed higher biodiversity archaea detection limit homozygotes subjects whereas methanogens detected cystic fibrosis heterozygotes healthy subjects qpcr results revealed low frequency sulfate reducing bacteria homozygote heterozygote patients cystic fibrosis compared healthy subjects pioneer study showing patients cystic fibrosis exhibit significant reduction consuming microorganisms could increase hydrogen accumulation colon expulsion gas non microbial routes
civil engineering structures often subjected multidirectional actions earthquake ground motion lead complex structural responses contributions latter multidirectional actions response highly coupled leading mimo system identification problem compared single input multiple output simo system identification mimo problems computationally complex error prone paper new system identification strategy proposed civil engineering structures multiple inputs induce strong coupling response proposed solution comprises converting mimo problem separate simo problems decoupling outputs extracting contribution respective input signals outputs end factorization based decoupling method employed performance examined three factors affect accuracy decoupling result including memory length input correlation system damping investigated additionally system identification method combines autoregressive model exogenous input arx eigensystem realization algorithm era proposed associated extended modal amplitude coherence modal phase collinearity used delineate structural noise modes fitted arx model efficacy arx era method demonstrated identification modal properties highway overcrossing bridge copyright john wiley sons ltd
sexual masochism disorder considered prevalent paraphilia among women however little known etiology clinical correlates involved disorder aimed addressing issue potentially high risk clinical cohort case control study consisted women met dsm criteria borderline personality disorder bpd women personality disorders groups sexual masochism disorder comorbidity assessed structured clinical interview sexual disorders module several etiological psychosexual personality features measured sexual masochism disorder times higher bpd women women personality disorders among bpd women sexual masochism disorder reported child sexual abuse hostile dismissing attachments higher sensation seeking frequently exploratory impersonal sexual fantasies bpd without sexual masochism correlation analysis confirmed significant positive relationship disinhibition sexual masochism severity bpd women findings point bpd women may represent high risk cohort especially higher disinhibition detached attachment childhood sexual abuse may also play predispositional role comorbidity research may help elucidate intriguing relationship disorders
flow downward divergent channel turns interesting experimental setup observation upward floating bubbles appear levitating view observer detailed analysis flow characteristic parameters necessary better understanding phenomenon boundary layer theory used derive velocity field experimental setup actual flow liquid presence bubble studied experimentally measuring position bubble data statistically processed image analysis observation bubble positions distribution showed reasonable assume flat velocity profile liquid channel bubbles tend move boundary layer experiments volume air bubbles floating water bubbles floating aqueous glycerin thus experiment used work suitable reliable determination instantaneous average bubble rising velocities well horizontal vertical oscillations institute chemistry slovak academy sciences
paper present novel technique security two dimensional data help cryptography steganography presented approach provides multilayered security two dimensional data first layer security developed cryptography second layer steganography advantage steganography intended secret message attract attention object scrutiny paper proposes novel approach encryption decryption information form word data doc file pdf document pdf file text document gray scale images rgb images etc using vigenere cipher associated discrete fourier transform dft hiding data behind rgb image steganography earlier developed techniques provide security either pdf data doc data text data image data types two dimensional data existing techniques used either cryptography steganography security proposed approach suitable types data designed security information cryptography steganography experimental results word data pdf document text document gray scale images rgb images support robustness appropriateness secure transmission data security analysis shows presented technique immune cryptanalytic technique provides security decryption check behind rgb color information hidden
article challenge idea one way relationship tourists supposed contribute economic resources freer gender roles development empowerment poor rural traditional women reflecting located gendered embodied position ethnographic fieldwork among women performing bobbin lace coast death galicia spain analyze gender roles stereotypes interact directions leading misunderstandings performances pride resentment behalf craftswomen gender stereotypes associated craftswomen tourist gaze affective fluxes policies economy heritage regimes changing contexts also embodied traditionalizing craftswomen curtailing flexible economic practices transforming crafts bodies something culture
present four band polarization insensitive terahertz metamaterial absorber formed four square metallic rings metallic ground plane separated dielectric layer found structure four distinctive absorption bands whose peaks average mechanism four band absorber attributed overlapping four resonance frequencies mechanism absorption investigated distributions electric field particular frequency absorption peak flexibly controlled varying size corresponding metallic ring proposed concept applicable types absorber structures readily scaled structures working microwave frequency range moreover characteristic design used design five band metamaterial absorber adding one metallic ring proposed absorber potential applications detection imaging stealth technology
bim building information modelling developed powerful solution improve many aspects construction industry current research regarding impact orientation building energy needs seldom tap potential bim study investigates impact orientation energy consumption small scale construction assesses bim used facilitate process methods adopted three fold firstly real life building modelled using revit one leading bim tools secondly green building extensible markup language model exported green building studio one leading energy simulation software thirdly green building studio different building orientations adopted impacts whole building energy investigated based analysis energy consumption corresponding different orientations emerged well orientated building save considerable amount energy throughout life cycle specifically total electricity use difference kwh total gas use difference leading combined energy cost savings pound throughout year period best degrees worst degrees orientations building achieved elsevier ltd rights reserved
fbd function block diagram widely used implement safety critical software plc programmable logic controller based digital nuclear reactor protection systems software developed strictly accordance safety programming guidelines nureg software engineering tools plc vendors enable present structural analyses using fbd programs specific rules pertaining guidelines enclosed within commercial tools specific links guidelines clearly communicated paper proposes set rules structure fbd programs accordance guidelines develop automatic analysis tool fbd programs written plcopen format proposed tool fbd program transformed open format analyzed plc platform independently consider case study fbd programs obtained preliminary version korean nuclear power plant demonstrate effectiveness potential proposed rules analysis tool elsevier ltd rights reserved
myeloproliferative neoplasia mpn associated pulmonary hypertension included group five recent clinical classification mpns heterogeneous group disorders includes disorders primary expression myeloid phenotype disorders characterized expression janus kinase jak mutation latter includes essential thrombocytosis polycythemia vera idiopathic myelofibrosis pulmonary extra medullary hematopoiesis emh refers presence hematopoietic precursor cells lung rare complication associated myelofibrosis present case series highlighting clinical pathological radiological features pulmonary emh underlying polycythemia vera
prenatal alcohol exposure lead behavioral cognitive impairments across multiple domains many brain regions impacted prenatal alcohol exposure also linked olfactory processing odor identification deficits documented certain neurological disorders associated brain regions odor identification following prenatal alcohol exposure well studied compared odor identification children prenatal exposure alcohol typically developing controls con group hypothesized children group would perform poorly children con group san diego odor identification test identification test common household odorants children exposed alcohol prenatal development significantly impaired olfactory identification compared typically developing controls findings confirmed hypothesis prenatal exposure alcohol associated odor identification deficits suggest research warranted identify mechanisms underlying deficits integrity brain areas involved determine whether olfactory performance might contribute better identification children risk behavioral cognitive deficits elsevier inc rights reserved
delivery novel bioactive scaffolds repair bone defects remains prominent challenge worldwide currently osteoporosis disease caused low bone mineral density affects million people worldwide half population experiencing least one fracture within lifetime recently temperature sensitive isopropylacrylamide butyl methylacrylate nanogel pib nanogel scaffolds emerged biomaterial candidate regenerative therapies advantage injected syringes soluble gel form capable delivering growth living progenitor cells yet hardens reaches body temperatures although material demonstrates optimal clinical delivery scaffolds main drawback low osteoconductivity bioactivity recently demonstrated mesoporous bioactive glass mbg loaded strontium able regenerate osteoporotic defects vivo enhance osteoblast differentiation vitro aim study combine advantages two therapies prepare pib nanogel scaffolds containing mbg investigate ability regenerate femur defects created ovarectamized rats results demonstrate groups containing mbg within nanogel formulation significantly higher new bone formation compared modalities demonstrate although nanogel demonstrated poor osteogenic ability addition osteoblasts worked synergistically mbg particles enhance regeneration created femur defects osteoporotic animals conclusion pib nanogel scaffolds viable treatment modality bone tissue engineering may serve carrier scaffold osteogenic cells bioactive scaffolds mbg wiley periodicals inc
background textbooks play important role engineering education influencing instructors pedagogical approaches providing much information students learn research explored students recollections roles textbooks played educational experiences students actually use textbooks remains largely unexplored purpose phenomenological study describes engineering students textbook use problem solving activities study directly examined students employed textbook order generate detailed descriptions students behaviors approaches reflections regarding actual problem solving experiences method ten senior materials engineering students males females asked think aloud solving engineering problems follow retrospective interviews regarding think aloud session conducted gain depth information students textbook use problem solving activities results students used textbook primarily find information related problem constraints explicitly stated problem furthermore textbook example problems exerted strong influence students problem solving processes students also reported limitations textbook contrasting diversity resources available via internet conclusions study provides insight students textbook use engineering problem solving activities students limited application textbook problem solving suggests textbooks may serving intended purposes
calreticulin calr jak gene mutations major genetic mutations patients primary myelofibrosis pmf essential thrombocythemia exert different effects clinical features outcomes diseases analyzed patients pmf respectively determined differences clinical characteristics patients jak compared calr mutations frequency jak calr mutations respectively patients calr mutations younger lower white blood cell count lower rate thrombotic events patients jak mutation neutrophil alkaline phosphatase nap score patients calr mutations significantly lower normal controls mainly due high proportion nap negative neutrophils first report show association calr mutations patients myeloproliferative neoplasms mpn nap score although mechanism unclear nap score could useful reliable biochemical marker discriminate mutational status mpn patients investigation warranted determine whether characteristics contribute pathogenesis mpn nap score
layered monolithic filter consisting nonwoven needlepunched woven monofilament geotextile presented paper two geotextiles mechanically bonded needlepunching process produce hybrid geotextile commercial scale fuzzy woven side geotextile resulting needlepunching process ideally suited lamination geonet although standalone filter application also possible filter press tests geotextile fly ash slurry yielded retention efficiency gradient ratio values hydraulic conductivity ratio values obtained fly ash fgd gypsum four power plants four field basin tests performed ccrs wherein effluent parameters total suspended solids total dissolved solids turbidity conductivity monitored time field tests showed fly ash fgd gypsum contained test basins migrating time elsevier ltd rights reserved
physical education teachers physically demanding job putting considerable risk musculoskeletal injuries structurally develop tailored injury prevention programmes teachers clear understanding extent characteristics underlying factors musculoskeletal injuries compared referents necessary therefore current study prospectively followed teachers non teachers registered musculoskeletal injuries time exposure sports participation one school year pearson tests independent samples tests determined significant differences non teachers regarding demographics variables possibly related injury occurrence teachers non teachers injuries teacher school year difference significantly different adjustment hours spent weekly intracurricular teaching career injury history preceding six months teachers affected body parts knee back teachers extensive injury history higher work sport index practiced sports taught extracurricular sports future injury prevention programmes take account great injury history heavy physical load teachers
introduction clinical settings acute anterior uveitis aau could first presentation ankylosing spondylitis based hypothesis investigate whether aau risk factor developing later using national health insurance research database nhird taiwan materials methods cohort comparison study used longitudinal taiwanese nhird probe relative risk odds aau development consisted patients diagnosed aau icd codes relative risks aau patients controls compared estimating crude hazard ratio logistic regression kaplan meier analysis used calculate cumulative incidence rates developing log rank test used analyze differences survival curves separate cox proportional hazard regressions performed compute free rate adjusting possible confounding factors age sex results crude hazard ratio aau group adjusted hazard ratio aau group observation time free group shorter aau patients compared control group versus days moreover aau patients younger age onset aau less years old would lead earlier diagnosis later median versus days survival group age onset aau greater years old difference statistically significant conclusions aau risk factor identify aau extra articular manifestation crucial early diagnosis treatment containing functional loss accordingly
impairment daily functioning still represents major treatment issue schizophrenia depth knowledge underlying constructs crucial interventions translate better outcomes study aims model factors influencing functional capacity real life behaviour sample outpatients chronic schizophrenia comprehensive assessment including evaluations psychopathology cognitive social cognitive abilities premorbid adjustment family environment early childhood experiences significant correlation observed functional capacity real life behaviour functional capacity significantly predicted real life behaviour significantly predicted empathy affect recognition symptoms functional capacity seems mainly related neurocognition whereas real life behaviour appears complex requiring integration different factors including symptoms major role empathy results thus support divergence two constructs functioning underlying components highlight need target dimensions individualized sequential rehabilitation programs order optimize functional outcome
objective assess performance tirads classification prospective surgical cohort demonstrating clinical usefulness methods june october patients assessed pre operative ultrasound included irb approved study nodules categorised according previously described tirads classification final pathological diagnosis obtained thyroidectomy specimen sensitivity specificity positive negative predictive values likelihood ratios calculated results study included patients nodules average nodules patient median size malignancy tirads tirads tirads subgroups tirads tirads tirads tirads cut point tirads perform fnab obtained sensitivity specificity ppv npv plr nlr malignancy conclusion based tirads classification allows selection nodules requiring fnab recognition low malignancy risk
basal slip dynamic recovery dislocations long assumed main mechanisms accounting sharp texturing magnesium alloys upon dynamic recrystallization high temperature basal slip allows basal plane mitigate stress reorienting axis normal loading direction dynamic recovery allows dislocations rearrange subgrains maintaining basal plane parallel main loading axis phenomena though pertaining unquestionable laws plasticity thermodynamics fully explain preferred selection crystal orientation nucleation growth dynamically recrystallized grains example extrusion basal plane reorients one two directions either theaxis theaxis parallel extrusion direction also grain boundary misorientation relationships established recrystallized parent grains paper electron backscattered diffraction ebsd characterization partially recrystallized microstructures molecular dynamic simulations interfacial defect theory used uncover mechanisms leading phenomena texture formation dynamic recrystallization simulations show grain boundary energy mobility emerge key governing effects experimentally observed preferred orientation selection nucleation growth due low crystal symmetry inherent hexagonal close packed structure magnesium certain grain boundaries possess low interfacial energies high mobilities relative boundaries making prime candidates accommodating subgrain rotation particular new experimentally observed bar twin boundary associated texture formation simulations theory show twin boundary highly mobile disconnectipn wide dislocation core presumably causing affected grains dominate final texture acta materialia inc published elsevier ltd rights reserved
paper candidate satellite radio interface satellite orthogonal frequency division multiplexing sat ofdm satellite component imt advanced presented sat ofdm based long term evolution lte terrestrial radio interface maximum commonality imtadvanced terrestrial radio interface paper deals configuration performance gpp lte based satellite radio interface enhancement satellite specific radio interface addresses possible adaptation gpp lte satellite order maximize performance satellite link
paper result research aim new didactical elements guiding module using tic technologies information communication electrical circuit laboratories faculty electrical engineering universidad costa research begins identifying current laboratories strategies local national international context using descriptive quantitative research methodology work showed need propose guiding module help students develop knowledge even helps autonomous investigate meditate criticize practice role teacher give support proposals module guides research according results required promotion diffusion electrical circuits course using tic get goal significant learning transform traditional teaching methodology noted using tools ensure improvement academicals performance
light exposure regulates several circadian functions normal humans including sleep wake cycle individuals alzheimer disease often regular patterns activity rest rather experience random periods sleep agitation day night bright light day darkness night shown consolidate activity periods day rest periods night patients important characteristics bright light exposure quantity spectrum distribution timing duration achieving results patients yet understood recent research shown moderate similar cornea blue similar light effective suppressing melatonin normal humans hypothesized blue light applied patients retire beds night would measurable impact behavior pilot study conducted days senior health care facility using four individuals diagnosed mild moderate levels dementia four patients exposed arrays blue light light emitting diodes max wavelength two hour sessions hours days control exposed red light max wavelength two hour sessions days prior blue light exposure despite modest sample size exposure blue leds shown affect sleep quality median body temperature peak patients median body temperature peak delayed approximately hours exposure blue leds compared exposure red leds sleep quality improved pilot study demonstrated light especially leds important contribution helping patients regulate circadian functions
experimental studies find strong influence nonverbal signals evaluation political candidates raters asked judge unknown candidates short duration exposures yet viewers exposed candidates verbal nonverbal communication naturally occurring context presence verbal communication make influence nonverbal communication seem attenuated link findings present study uses continuous response measurement uncover relative influence verbal nonverbal communication political opinion formation debate clip lasting minutes analysis suggests nonverbal communication influences candidate evaluations especially beginning presentation verbal communication seems influential remaining time consistent trend study participants post exposure opinions influenced verbal nonverbal communication
background fingolimod slows heart rate due vagomimetic effects might cause additional cardiovascular autonomic changes time course changes well described extent course cardiovascular autonomic changes upon fingolimod initiation yet evaluated study therefore intended assess cardiovascular autonomic changes first fingolimod initiation methods patients relapsing remitting multiple sclerosis rrms recorded respiration resp electrocardiographic interval rri systolic diastolic blood pressure bpsys bpdia rest fingolimod initiation calculated parameters total autonomic modulation rri standard deviation rri rri coefficient variation rri rri total powers mainly sympathetic cardiac modulation rri low frequency powers sympathetic modulation bpsys powers parasympathetic modulation square root mean squared difference successive rris rmssd rri high frequency powers sympatho vagal cardiac balance rri ratios baroreflex sensitivity brs compared parameters eight measurements analysis variance anova friedman test post hoc analysis significance results fingolimod initiation resp bpsys bpsys powers remained unchanged rris rri rri rri total powers rri powers rmssd rri powers brs increased rose peak values occurring respectively bpdia decreased significantly lowest rri ratios decreased nadir conclusions increases parasympathetic overall cardiac autonomic modulation brs seen fingolimod initiation theoretically beneficial patient cardiovascular system however long term studies must show whether effects persist attenuated due receptor regulation upon continued fingolimod therapy
reuse designers knowledge experience solving problems engineering design process holds key increase efficiency decision making future projects important part useful knowledge experience interpretation data information design objects processes well generation new information decision making however previous studies knowledge representation models mainly focused developing structure describe knowledge design objects design processes systematic method effectively integrate knowledge design objects knowledge problem solving strategies still missing fill gap rfbse knowledge representation model capturing useful design knowledge experience future reuse developed evaluated study paper describes key elements model explains rationale using particular elements discusses evaluation model using engineering design example elsevier ltd rights reserved
paper concept multi objective optimization introduced automation placement task analog integrated circuits layout design bridge difficulties found state art works fulfilling proximity constraints cells organized proximity groups implement desired set symmetry proximity requirements innovative archived based multi objective simulated annealing algorithm operating absolute representation proposed optimize placement proximity group contrast traditional single objective placement approaches resulting pareto fronts placements representing tradeoffs optimization objectives group combined bottom design hierarchy final front obtained way problem complexity reduced split multiple executions optimization kernel less design variables also analog designer becomes aware design tradeoffs proposed multi objective hierarchical methodology implemented experimental results prove previous efforts single objective absolute representations match obtained floorplans furthermore obtained pareto fronts contain solutions found recent published topological representations well known microelectronics center north carolina benchmark sets allowed improvement placement area previously optimized folded cascode operational amplifier united microelectronics corporation fabrication process elsevier ltd rights reserved
objective repair cartilaginous lesions within synovial joints still unresolved weighty clinical problem although research activity area indefatigably sustained significant progress made past decade aim educational review heighten awareness amongst students scientists basic issues must tackled resolved hope escape whirlpool stagnation fallen cartilage repair redivivus design articular cartilage lesions may induced traumatically sports injuries occupational accidents pathologically course degenerative disease osteoarthritis review addresses biological basis cartilage repair surveys current trends treatment strategies focussing widely adopted orthopaedic surgeons viz abrasive chondroplasty microfracturing microdrilling osteochondral grafting autologous chondrocyte implantation aci also described current research activities field cartilage tissue engineering therapeutic principle holds promise success experimental approach results conclusions tissue engineering aims reconstitute tissue structurally functionally process conducted entirely vitro initially vitro vivo situ entirely vivo three key constituents usually form building blocks approach matrix scaffold cells signalling molecules proposed approaches none yet advanced beyond phase experimental development level clinical induction hurdles need surmounted ultimate success discussed published elsevier ltd behalf osteoarthritis research society international
semi empirical approach model temperature effects characteristics carbon nanotube field effect transistors cntfets proposed model includes two thermal parameters describing cntfet behaviour terms saturation drain current threshold voltage whose values extracted simulated trans characteristics device different temperature conditions results compared numerical model online available obtaining characteristics comparable lower cpu calculation time
study perceived enjoyment different movie genres online experiment students randomly divided two groups asked estimate much closest friends young people general enjoyed either serious light hearted movies self differences perceived enjoyment serious light hearted movies also assessed function differing individual motivations underlying entertainment media consumption results showed clear third person effect light hearted movies first person effect serious movies third person effect light hearted movies moderated level hedonic motivation participants high hedonic motivations perceive others enjoyment light hearted films differently however eudaimonic motivations moderate first person perceptions case serious films
cryptococcal meningitis important fungal infection among systemic lupus erythematosus patients conducted pooled analysis systematic review describe epidemiological clinical profile cryptococcal meningitis systemic lupus erythematosus patients two hospitals china nine literature databases cases prevalence data collected pooled analysis meta analysis respectively categorical variables cases compared using chi test statistical program sas multiple regression analysis performed ascertain independent predictors significantly correlated prognosis meta analysis conducted statistical program prevalence cryptococcal meningitis systemic lupus erythematosus patients patients predominantly females adults prednisone equivalent day infection associated higher mortality odds ratio patients showed low lupus activity developed crytococcal infection moreover patients misdiagnosed estimated case fatality rate results suggest emphasis placed understand lupus related cryptococcal meningitis develop better prophylaxis management strategies combat condition
objective identify possible gray matter alterations patients chronic migraine using voxel based morphometry vbm background vbm studies demonstrate structural alterations gray matter episodic migraine patients alterations correlate disease duration headache frequency assessed alterations chronic migraine evaluate concept migraine progressive disorder brain methods individually age sex matched subjects without aura healthy controls per group underwent magnetic resonance imaging based vbm results found increase volume gmv amygdala putamen compared controls gmv compared controls differ statistically significantly headache frequency migraineurs correlated positively gmv putamen frontal temporal gyrus negatively left cuneus conclusion associated structural changes brain regions involved pain processing also affective cognitive aspects pain alterations correlated headache frequency assessed findings support assumption chronic pain alters brain plasticity gmv increase may reflect remodeling central nervous system due repetitive headache attacks leading chronic sensitization continuous ictal like state brain chronic migraineurs
background bradykinin mediated angioedema rare disease characterised recurrent angioedema linked acquired angiotensin converting enzyme inhibitor induced hereditary disorders type clinical picture misleading diagnosis disease sometimes difficult bradykinin mediated attack may therapeutic emergency requires access effective expensive treatments prescription must therefore justified specific marker acute bradykinin mediated attacks yet identified facilitate therapeutic decision sought many studies purpose article reviews literature type biomarker comparing candidate bradykinin mediated markers candidate markers mast cell activation conclusion interesting biomarkers linked endothelial stress cadherin selectin endothelin von willebrand factor activity significantly increased attack markers must validated prospective studies determine specificity utility diagnosis
purpose physiological flow dynamics within valsalva sinuses terms global local parameters still fully understood study attempts identify physiological conditions closely possible give explanation different sometime contradictory results literature methods vitro approach implemented testing porcine bio prosthetic valves operating within different aortic root configurations tests performed pulse duplicator physiological pressure flow conditions fluid dynamics established various cases analysed means particle image velocimetry related achieved hydrodynamic performance results configuration associated substantially different flow dynamics significantly affects valve performance configuration closely replicating healthy native anatomy characterised best hemodynamic performance mismatch size position valve root produced substantial modification fluid dynamics downstream valve hindering hydrodynamic performance system worst conditions observed configuration characterised total absence valsalva sinuses conclusion study provides explanation different vortical structures described literature downstream bioprosthetic valves enlightening experimental complications valve testing importantly results clearly identify fluid mechanisms promoted valsalva sinuses enhance ejection closing phases study exposes importance optimal integration valve root operate single system authors published elsevier ltd
study explored experience stereotyped group black south african adolescents participants black adolescents ages females majority ethnicity setswana adolescents participated focus group discussions experience ethnicity based stereotyping others data thematically analysed adolescents reported experience identity compromising stereotyping related gender roles sexual orientation race language gender based stereotypes predominantly related education career opportunities females perceived less educated poorer career prospects male peers racial stereotyping linked discrimination xenophobia different distrusted individuals choose speak english stereotyped culturally superior speak indigenous languages adolescents reported cope stereotyping taking actions contradict stereotypical expectations find common goals increase intergroup cooperation appreciate difference uniqueness people stereotype vulnerability adolescent groups confirmed well stereotypes shape identity outcomes addition importance intergroup contact eradicate stereotypes reiterated
key aspect realizing future smart grid communication solution balanced approach network performance network security network deployment high security communication flow path useful network path support capacity reachability requirements deployment phase communication network facilitate optimal network path focusing network performance network security time paper describe use case smart grid application security network capacity reachability needs optimal successful network operation explain proposed balancing approach network performance network security useful optimal smart grid secure system design
population aging societies requires providing elderly safe dependable assistive technologies daily life activities improving fall detection algorithms play major role achieving goal article proposes real time fall prediction algorithm based acquired visual data user walking assistive system depth sensor lack coupled dynamic model human assistive walker hybrid system identification machine learning approach used autoregressive moving average arma model fitted time series walking data forecast upcoming states hidden markov model hmm based classifier built top arma model predict falling upcoming time frames performance algorithm evaluated experiments four subjects including experienced physiotherapist using walker robot five different falling scenarios namely fall forward fall fall back fall left fall right algorithm successfully predicts fall rate
orthogonal connectors used drawings many types network diagrams especially representing electrical circuits one approach routing connectors compute orthogonal visibility graph formed intersecting vertical horizontal lines projected corners obstacles use search graph however search slow since many routes sense topologically equivalent introduce obstacle hugging routes conjecture provide canonical representative set topologically equivalent routes also introduce new bend visibility graph supports computation canonical routes essentially contains node obstacle corner connector endpoint diagram edge two nodes iff connected using orthogonal connector one bend show use bend visibility graph significantly improves speed orthogonal connector routing
background aims foodborne illness affects population year risk factor irritable bowel syndrome ibs evaluated risk risk factors outcomes ibs infectious enteritis methods performed systematic review electronic databases august identify cohort studies prevalence ibs months infectious enteritis used random effects meta analysis calculate summary point prevalence ibs infectious enteritis well relative risk compared individuals without infectious enteritis host enteritis related risk factors results identified studies comprising individuals enteritis followed months years development ibs pooled prevalence ibs months infectious enteritis confidence interval months infectious enteritis risk ibs fold higher patients infectious enteritis past months risk ibs fold higher individuals infectious enteritis months ago individuals patients enteritis caused protozoa parasites developed ibs patients enteritis caused bacterial infection developed ibs risk ibs significantly increased women odds ratio individuals antibiotic exposure anxiety depression somatization neuroticism clinical indicators enteritis severity considerable level heterogeneity among studies conclusions systematic review meta analysis found patients infectious enteritis develop ibs later risk ibs fold higher individuals infectious enteritis although heterogeneity among studies analyzed women particularly severe enteritis increased risk developing ibs individuals psychological distress users antibiotics enteritis
novel observer based fault accommodation technique linear multi input multi output sampled data systems affected general class actuator faults presence quantization errors addressed paper output signal assumed available direct measurement simulation study three tank system supports theoretical developments copyright john wiley sons ltd
order explain macroscopic radiative behaviour open cell ceramic foam knowledge solid phase distribution space radiative contributions solid phase required solid phase open cell ceramic foam arranged porous skeleton composed interconnected network ligament typically ligaments based assembly grains less compacted exhibit anisotropic geometry concave cross section lateral size one hundred microns therefore ligaments likely emit absorb scatter thermal radiation framework explains experimental investigations scale must developed extract accurate homogenized radiative properties regardless shape size ligaments support development numerical investigation radiative intensity propagation real world ligament beforehand scanned ray micro tomography presented paper radiative transfer equation rte applied resulting meshed volume solved combining discrete ordinate method dom streamline upwind petrov garlekin supg numerical scheme particular attention paid propose improved discretization procedure spatial angular based ordinate parallelization aim reach fast convergence towards end article present effects played local radiative properties three ceramic materials silicon carbide alumina zirconia often used designing open cell refractory ceramic foams elsevier ltd rights reserved
introduction patients essential thrombocythemia vascular complications contribute morbidity mortality better predict occurrence thrombotic events international prognostic score thrombosis essential thrombocythemia ipset thrombosis recently proposed present application score compare results usual classification system method retrospectively evaluated characteristics risk factors thrombosis patients diagnosis seen last years faculdade medicina abc fmabc results thrombosis arterial territory prevalent venous sites observed cardiovascular risk factors hypertension hypercholesterolemia diabetes mellitus smoking also risk factors thrombosis age years presence jak mutation associated occurrence thrombotic events patient classified ipset thrombosis low risk thrombotic event furthermore using ipset thrombosis scale identified two patients thrombotic events follow otherwise classified low risk group traditional classification leukocytosis diagnosis significantly associated arterial thrombosis splenomegaly associated venous thrombotic events conclusion cardiovascular risk factors leukocytosis directly associated arterial thrombosis ipset thrombosis appears better traditional classification identifying lower risk patients need specific therapy
although previous studies reported altered topology brain functional networks patients parkinson disease modular organization brain functional networks patients remains largely unknown using resting state functional mri fmri graph theory examined modular organization brain functional networks unmedicated patients early mid motor stage healthy controls compared controls patients tended show decreased integrity segregation within modules inferred significantly increased intra modular characteristic path length within four modules mpfc smn fpn decreased inter modular functional connectivity mpfc smn decreased intra modular clustering patients intra modular characteristic path length within mpfc showed significantly positive correlation general cognitive ability group receiver operating characteristic roc analysis revealed mpfc highest significant accuracy differentiating patients controls findings may provide new insight understanding pathological changes underlie impairment cognition movement parkinson disease
today uncommon meet someone begin romantic relationship online meeting dating website differs meeting person dating profile created first allows others review potential romantic partners studies examined romantic attraction within online dating context even fewer examined gender roles may influence attraction current study female examined effects gender role congruence physical attractiveness romantic interest college students participants viewed online dating profiles varied physical attractiveness adherence gender role norms results indicated men women preferred attractive gender role incongruent dating partners average looking gender role congruent contrary previous research women differentiated profiles based physical attractiveness men especially gender role congruent profiles men especially interested attractive gender role incongruent profiles physical attractiveness gender role incongruence greatest factor determined interest profile future research may need consider potential seriousness relationship defined expected length relationship influences online profile characteristics affect attraction interest elsevier ltd rights reserved
routinely observe others choices use guide whose choices influence prior work focused effect perceived similarity two individuals self others degree overlap past choices explicitly recognizable group affiliations real world however dyadic relationship part complex social structure involving multiple social groups directly observable suggest human learners beyond dyadic similarities choice behaviors explicit group memberships infer structure social influence grouping individuals including based choices use groups decide whose choices follow propose computational model formalizes idea test model predictions series behavioral experiments experiment reproduce well established finding people choices likely influenced someone whose past choices similar past choices predicted model well dyadic similarity models experiments test set unique predictions model looking cases degree choice overlap individuals equated choices indicate latent group structure apply model prior empirical results infants understanding others preferences presenting alternative account developmental changes finally discuss model relates classical findings social influence literature theoretical implications model taken together findings demonstrate structure learning powerful framework explaining influence social information decision making variety contexts
ros open source robot operating system widely used rapidly developed robotics community however running linux ros provide real time guarantees real time tasks required many robot applications robot motion control paper first time presents real time ros architecture called rtos multi core processors ros provides integrated real time non real time task execution environment real time non real time ros nodes separately run real time linux respectively different processor cores way real time tasks supported real time ros nodes real time non real time ros nodes linux provide functions ros furthermore high performance achieved executing real time ros nodes non real time ros nodes different processor cores implemented ros dual core processor conducted various experiments real robot applications experimental results show ros effectively provide real time support ros platform high performance exploring multi core architecture elsevier rights reserved
background blastocystis group cosmopolitan gastrointestinal parasite humans wide variety animals anaerobic protozoans include specific small subunit ribosomal rna subtypes nine found humans variable geographical distribution study described blastocystis subtypes present saudi arabia methods total faecal samples collected patients gastrointestinal complaints asymptomatic individuals visiting two major hospitals samples analysed diagnostic pcr microscopy culture methods subtypes blastocystis isolates determined sequenced tagged site sts based method results one hundred thirty three positive cases detected diagnostic pcr also positive culture method direct microscopy sensitivities direct microscopy culture method respectively subtype prevalent followed detected study infections significantly predominant among symptomatic patients conclusions knowledge study provides first run information blastocystis epidemiology makkah city revealing rather moderate prevalence presence three subtypes predominant particularly among symptomatic patients
performance bridges strong wind traffic great importance set traveling speed limit make operational decisions severe weather controlling traffic even closing bridge meanwhile vehicle safety highly concerned running bridges highways strong wind past two decades researchers made significant contributions simulation wind vehicle bridge system interactive effects paper aims provide comprehensive review overall performance bridge traffic system strong wind including bridge structures vehicles associated mitigation efforts
purpose investigate agreement associations parent youth acknowledgment home food rules youth eating behaviors measures body composition excess weight methods parent youth dyads completed rules eating home scale active survey reported dietary intake trained research staff obtained anthropometric data linear regression analyses separately evaluated relationships youth parent acknowledgment rules youth reported eating behaviors anthropometric outcomes food rules evaluated item scale individually results score food rule scale positively associated fruit vegetable servings youth acknowledgment beta anthropometric outcomes rule desserts except fruit positively associated fruit vegetable servings youth beta parent beta acknowledgment rules second helpings meals limited fast food positively associated body mass index score youth beta beta respectively parent beta beta respectively acknowledgment similar results waist circumference score percent body fat conclusions inverse associations specific food rules healthful eating behaviors positive associations anthropometric outcomes suggest potentially bidirectional relationships food rule implementation youth weight future studies disentangle food rules guide youth behavior context youth weight status society adolescent health medicine rights reserved
background allergic diseases including allergic rhinitis asthma atopic dermatitis increasing worldwide common medications used treat inflammatory disorders anti histamines corticosteroids limitations short duration severe side effects thus interest complementary alternative medicine continually growing investigate anti inflammatory mechanisms tonggyu tang tgt traditional korean medicine used treat patients allergic nasal disorders methods measured mrna expressions production pro inflammatory cytokines interleukin tumor necrosis factor alpha tnf alpha pcr elisa assays hmc human mast cell line hacat cells immortalized human keratinocytes moreover evaluated effect tgt two major inflammation related pathways mitogen activated protein kinase mapk kappa signaling pathway two cells results results revealed tgt significantly reduced expression production inflammatory cytokines tnf alpha agonist treated hmc hacat cells also found tgt suppressed mapk signaling pathway including extracellular signal regulated kinase erk mitogen activated protein kinase jun terminal kinase jnk well kappa pathway known regulate inflammatory cytokine expression conclusion taken together results demonstrate tgt inhibits expression pro inflammatory cytokines suppressing mapk pathway mast cells keratinocytes suggesting potential use tgt treating allergic inflammatory diseases
unraveling transcriptional heterogeneity labyrinthine nature neurodevelopment probe insights neuropsychiatric disorders noteworthy adult neurogenesis restricted subventricular subgranular zones brain recent studies suggest long non coding rnas lncrnas avant garde class regulators implicated neurodevelopment paucity exists knowledge regarding lncrnas neurogenesis associations neurodevelopmental defects address extensively reviewed existing literature databases well performed relevant silico analysis utilized allen brain atlas aba differential search module generated catalogue similar transcripts specific neurogenic zones including coding non coding transcripts explore existing lncrnas reported neurogenesis performed extensive literature mining identified lncrnas degenerate lncrnas mapped onto aba transcript list leading detection lncrnas specific neurogenic zones dentate gyrus lateral ventricle among showed associations several neurodevelopmental disorders following silico mapping onto brain disease databases like simons foundation autism research initiative autdb lncrnadisease notably using aba correlation module could establish lncrna mrnacoexpression networks candidate lncrnas finally pathway prediction revealed physical biochemical regulatory interactions nine lncrnas addition aba differential search also revealed novel significant lncrnas null set similar conclusively review represents updated catalogue lncrnas neurogenesis neurological diseases overviews field omics based data analysis understanding lncrnome based regulation neurodevelopment
despite health safety legislation ergonomics regulations several years many swedish companies still unable effectively prevent consequences poor ergonomics corrective measures often made late employees complain work related disorders already occurred besides several studies shown poor ergonomics result deteriorated assembly quality reduced productivity late measures often costly studies proven design engineers often unaware design consequences know apply ergonomics principles new product production design therefore purpose study explore required improve situation one way find ask engineers involved product production development thus engineers design manufacturing engineering five swedish companies interviewed ergonomics conditions related quality productivity issues general answers unexpectedly demonstrated fairly good awareness implications poor assembly ergonomics also appropriate product production design methods tools prevent missing respondents thought poor ergonomics could result reduced product quality stated profitability calculations necessary changes poor ergonomic solutions said ergonomics risks accepted due lack appropriate calculation methods altogether many suggestions emerged improve product production design methods tools order achieve complete sustainable manufacturing solutions relevance industry relationship ergonomics assembly quality deserves attention order achieve good working conditions sustainable cost efficient manufacturing solutions assembly ergonomics quality relationships must therefore proactively considered already early design phases new product assembly concepts elsevier rights reserved
partitioning geometric data two sets one corresponding high frequencies low frequencies critical operation second generation wavelet multiresolution analysis geometric point view region high variability within vertex neighborhood certain scale indicates correlation signal frequency dominates scale thus prospect abilities several geometric variability descriptors robustly identify features consider three descriptor families based principal component analysis surface fitting quadric error metrics assess quality descriptor employ lazy wavelet simplification digitized models since usually contain noisy geometric structures multiple scales resolutions inferred difference simplified model highest resolution representation measured objectively using averaged local distance functions
affective coldness one main features machiavellianism recent studies revealed machiavellians emotionally detached affective blunting associated intense feelings emotional instability negative emotions difficulty enduring distress used brain imaging techniques investigate emotion regulation machiavellianism neuropsychological level used situations participants required demonstrate emotional flexibility explore controversy surrounding fact machiavellianism associated cold mindedness emotional instability participants performed reappraisal task emotionally evocative pictures international affective picture system presented different contexts negative positive neutral asked interpret scenario according title reinterpret according another context created new title negatively labeled pictures shifted positively labeled ones task performance machiavellians showed increased activation brain regions associated emotion generation example amygdala insula indicates machiavellian individuals able involved emotionally social situations increased activation temporal parahippocampal regions reappraisal suggests machiavellians use semantic perceptual processes construct alternative interpretations situation enhanced memory emotional stimuli furthermore seem possess intense awareness leads shift attention external internal information detect environmental changes cognitive processes may enable adjust behavior quickly study supports flexibility hypothesis machiavellianism suggests machiavellians approach emotion regulation linked rational mode thinking
although cases child abuse among migrant families often reported social media issue child maltreatment among migrant families china received little empirical attention study investigated prevalence child maltreatment parents among migrant families individual family community level risk factors associated child abuse context survey conducted migrant local adolescents shenzhen south china stratified two stage cluster sampling design logistic regression analysis conducted compare prevalence maltreatment migrant local adolescents also explore risk factors associated psychological physical maltreatment groups results showed parent child abuse prevalent among migrant local adolescents migrant adolescents times likely psychologically physically abused parents local counterparts low academic performance delinquent behavior family economic adversity low parent attachment put migrant adolescents increased risk psychological physical maltreatment neighborhood disorganization significantly related psychological aggression among migrant adolescents findings confirm child abuse perpetuated parents serious problem mainland china especially among migrant families implications policy practice discussed elsevier ltd rights reserved
describe development new methodology focusing labeling sulfonyl carbamates multicomponent reaction comprised sulfonyl azide alkyl alcohol number labeled sulfonyl carbamates synthesized isolated developed methodology applied preparation biologically active molecule target compound obtained isolated radiochemical yield evaluated binding properties tumor cell assay vivo biodistribution imaging studies also performed represents first successful radiolabeling non peptide angiotensin receptor subtype agonist currently clinical trials treatment idiopathic pulmonary fibrosis
purpose renal dimensions important assessment genitourinary tract used evaluate critical aspects renal growth development understanding effect patient position important use interpret parameters prospective study determined effect patient position general body habitus renal length parenchymal area children undergoing renal ultrasound materials methods october january children underwent renal ultrasound prone supine bilateral renal length renal parenchymal area measured pearson bland altman statistical analyses used examine correlations measurement bias degree agreement methods results renal length measurements positions complete right left kidneys parenchymal area measurements complete kidneys children compared individually supine prone measures renal length parenchymal area highly correlated pearson analysis greater greater respectively compared method bland altman analyses differences means showed greater variance representing wide limits agreement poor interrelation neither persistent systematic bias body habitus influenced results conclusions pearson analysis showed high correlation supine prone renal measurements bland altman analysis renal length parenchymal area demonstrated wide limits agreement allowing interchangeable use prone supine measurements renal ultrasound specify standardized positions benchmarks results provide guidance standardize renal ultrasound measurements renal size used indicator kidney health
paper show first comprehensive experimental study mobile rfid reading performance based relatively large number tags making number observations regarding tag reading performance build model depict various parameters affect reading performance model designed efficient algorithms maximize time efficiency energy efficiency adjusting reader power moving speed experiments show algorithms reduce total scanning time percent total energy consumption percent compared prior solutions
previous time series panel studies asthmatics reported respiratory health effects following short term exposure ozone followed children aged years old athens thessaloniki greece weeks academic year recorded daily respiratory symptoms absenteeism peak expiratory flow pef applied mixed models controlling various possible confounders investigate daily associations exposure derived weekly personal fixed school site measurements calibrated using daily values fixed monitoring site nearest child school location pef presence symptom cough stuffy nose well absenteeism tested robustness findings varying modeling assumptions confounders investigated effect modification patterns medication use time spent outdoors prevalence asthma increase personal exposure associated increased odds symptom odds ratio confidence interval largely attributed increase odds stuffy nose pef absenteeism related exposure results robust several sensitivity analyses effects modified medication use presence symptoms also decreases pef mainly reported among non users effect estimates driven asthmatic subgroup children findings indicate short term exposure may associated respiratory symptoms extending previously reported results asthmatics general population
background although varicelliform kaposi eruption well known complication dermatoses widely investigated aim investigate features dermatoses herpes superinfection patients hospitalized dermatology department patients methods performed single centre retrospective study included cases kaposi varicelliform eruptions defined positive pcr unconventional site herpetic recurrence setting active dermatitis record compiled case giving details history clinical laboratory findings therapeutic data outcome results thirty four cases kaposi varicelliform eruptions subjects studied mean age diagnosis years underlying dermatoses follows pemphigus bullous pemphigoid cicatricial pemphigoid atopic dermatitis darier disease dermatoses patients presented skin mucous membrane lesions mostly erosive vesicular bullous often painful pruritic diagnosis undergoing systemic immunotherapy topical corticosteroids pcr positive hsv cases hsv cases indeterminate cases lymphocytopenia seen cases majority patients received treatment nine patients experienced least one relapse conclusion study confirms representation expected dermatoses pemphigus atopic dermatitis also others pemphigoid acute dermatoses results investigated systematic prospective study elsevier masson sas rights reserved
background high prevalence low testosterone levels along conventional risk factors diabetes mellitus type emerged studies conducted worldwide thus purpose present study evaluate relationship type serum testosterone levels material methods study conducted department medicine mlb medical college jhansi period years total diabetic patients controls randomly selected diabetic medicine opd ipd icu taking informed consent history examination free total testosterone levels sent overnight fasting data cases compared controls using student test value considered significant results study showed testosterone deficiency prevalent diabetic subjects comparison controls free testosterone levels significant terms difference means study control groups conclusions results based study carried concluded testosterone deficiency associated type diabetes mellitus also study showed free testosterone level affected total testosterone level type diabetes patients
purpose review increasingly need examining exposure disease associations large diverse datasets understand complex determinants pediatric disease disability recognizing children health research consortia important sources big data crucial pediatric research community knowledgeable challenges opportunities face present review provide examples existing children health consortia highlight recent pooled analyses conducted children health research consortia address common challenges pooled analyses provide recommendations advance collective research efforts pediatric research recent findings formal consortia collective science initiatives increasingly created share individual data set relevant epidemiological studies address common research topic concept joint effort many individual groups accomplish far working alone practical challenges participation investigators within consortia need addressed order work summary researchers access consortia data centers able far beyond initial hypotheses potentially accomplish research previously thought infeasible costly
arrangement proposed four stroke internal combustion engine recover thermal energy products combustion exhaust stroke store energy sensible heat micro channel regenerator matrix transfer stored heat compressed fresh charge flows regenerator succeeding mechanical cycle extra moveable piston locked preferred positions sequence valve events enable regenerator lose heat working fluid one interval time gain heat fluid another interval time paper examines whether scheme cylinder regeneration icr improves cycle thermal efficiency eta models various thermodynamic processes cycle treatments unsteady compressible flow heat transfer inside regenerator developed digital simulations cycle made compared idealized engine cycle devoid regeneration provisions icr seem deteriorate thermal efficiency compression ratio octane engine simulated equivalence ratio eta regeneration eta without study shows previous claims efficiency gains via icr using highly simplified models may misleading elsevier ltd rights reserved
article describes approach experts national research moscow state university civil engineering mgsu construction modern operating systems buildings using bim technology article performed within russian state task
work presents control system suitable high precision pulsed current sources proposed control system based detection events define changes power converter state produce required current waveform good dynamic response additionally control system designed regulate flat top current well defined precision order mitigate effect measurement noise estimation algorithm controlled current incorporated algorithm generates filtered version controlled variable without affecting control dynamics use estimated current allows improve detection events avoid increase number commutations due possible erratic comparisons estimator gains tuned using genetic algorithm techniques optimize root mean square value typical pulse furthermore order independently perform required set tasks proposed control system implemented using digital platform based field programmable gate array additionally due demanding precision applications different considerations regarding implementation digital wordlength binary point position rounding method overflow behavior taken account experimental results obtained application proposed control system laboratory prototype presented
introduction epithelial mesenchymal transition emt relates organ fibrosis malignant behavior cancer pirfenidone pfd anti fibrotic agent idiopathic pulmonary fibrosis one functions may inhibit fibrotic emt study aimed investigate possibility pfd might exert anti tumor effect inhibition emt non small cell lung cancer nsclc cell lines vitro vivo methods nsclc cells nci used evaluate pfd effects tgf induced phenotypic changes possible tgf signaling pathways modulated pfd evaluated effects pfd emt induced anti cancer drug also analyzed impact pfd tumor growth nude mice well emt change vivo also determined results pfd significantly inhibited tgf induced emt smad phosphorylation tgf receptor expression also inhibited translocation smad cytoplasm nucleus carboplatin induced elevation tgf production cancer cells together induction emt suppressed treatment pfd vivo examination pfd alone inhibit tumor progression whereas combination carboplatin significantly decreased tumor growth immunohistological analysis showed pfd suppressed emt change induced carboplatin conclusions pfd could attenuate emt process induced exogenous tgf also paracrine tgf produced nsclc cells pfd may promising new therapeutic agent treatment nsclc regulation emt elsevier rights reserved
one major issues use resonant photoacoustic cell resonance frequency cell frequency stable changes depend mostly temperature gas mixture paper presents new method tracking resonance frequency amplitude phase calculated input samples stimulating frequency adjusted resonance frequency cell based phase method implemented using digital measurement system analog digital converter field programmable gate array fpga microcontroller resonance frequency changed injection carbon dioxide cell theoretical description experimental results also presented
identified neuroprotein collapsing response mediator protein crmp noncanonical osteogenic factor regulates differentiation mouse bone marrow skeletal stem cells bone marrow stromal stem cells mbmscs osteoblastic cells crmp member crmp crmp family expressed mbmscs osteoprogenitors adult mouse human bones vitro gain function loss function crmp murine stromal cells revealed inhibitory effect osteoblast differentiation addition crmp deficient mice crmp displayed increase bone mass increased mineral apposition rate bone formation rate compared wild type controls increased bone mass crmp mice associated enhanced bmp signaling bmp induced osteoblast differentiation crmp osteoblasts obs furthermore crmp obs exhibited enhanced activation rhoa focal adhesion kinase fak signaling led cytoskeletal changes increased cell spreading addition crmp obs exhibited increased cell proliferation mediated via inhibiting cyclin dependent kinase inhibitor kip upregulating cyclin expression targets rhoa signaling pathway findings identify crmp novel negative regulator osteoblast differentiation american society bone mineral research
modular exponentiation important operation public key cryptography common multiplicand multiplication cmm modular exponentiation efficient exponentiation algorithm paper presents novel method speeding cmm modular exponentiation algorithm based modified montgomery modular multiplication algorithm algorithm uses new multi bit scan multi bit shift technique employing modified encoding algorithm algorithm three operations zero chain multiplication required additions nonzero digit multiplication relaxed multi bit shift one binary addition one clock cycle computational complexity analysis shows average number required multiplication steps clock cycles considerably reduced comparison cmm modular exponentiation algorithms
currently storage theory widely adopted rarely used procurement decision making construction especially green landscaping engineering seedlings storage different general products survival rates exert direct impact project quality progress therefore important green landscaping manufacturing engineering companies adopt scientific methods store seedlings article establishes mathematical model seedlings storage depth analysis practical manufacturing engineering problems applies mathematical model providing analysis solutions problem using storage model theory background limited storage capacity finally optimal seedlings procurement strategy set save costs enterprises maximum extent context limited storage capacity conveys application value green landscaping engineering companies make scientific procurement decision
finite element mesh generation major hurdle marine controlled source electromagnetic csem modeling paper present discretization operator fedo automatically converts finite difference model reliable efficient tetrahedral meshes csem modeling fedo sets wireframes background seabed model precisely honors seafloor topography wireframes partitioned multiple regions outer regions wireframes discretized coarse tetrahedral elements whose maximum size large skin depth regions demonstrate coarse meshes produce accurate solutions numerical dispersion errors tetrahedral meshes accumulate oscillates contrast central regions wireframes discretized fine tetrahedral elements describe complex geology detail conductivity distribution mapped meshes volume averaged sense avoid excessive mesh refinement around receivers introduce effective receiver size major advantages fedo summarized follow first fedo automatically generates reliable economic tetrahedral meshes without adaptive meshing interactive cad workflows second fedo produces meshes precisely honor boundaries seafloor topography third fedo derives multiple sets meshes given model mesh optimized different set sources receivers fed subgroup processors parallel computer divide conquer approach improves parallel scalability solution accuracy effectiveness fedo demonstrated various csem examples
medicare currently allows beneficiaries choose traditional medicare privately run plans medicare advantage program enrollment optional conventional observational estimates program impact potentially subject selection bias address issue use discontinuity rules governing mapayments health plans gives greater payments plans operating counties metropolitan statistical areas populations sharp difference payment rates population cutoff creates greater incentive plans increase generosity benefits therefore enroll beneficiaries counties versus cutoff find expansion margin reduces beneficiaries hospital use mortality
recent neuroimaging work identified network regions work concert update impressions people particularly response inconsistent behavior however specific functional contributions regions updating process remain unclear using fmri tested whether increases activity triggered inconsistent behavior reflect changes stored representations people response behavioral inconsistency merely response inconsistency participants encountered series individuals whose behavior either changed attributionally meaningful fashion merely inconsistent immediately preceding behavior observed left ventrolateral prefrontal cortex vlpfc left inferior frontal gyrus ifg preferentially recruited response unexpected immoral behavior whereas separate set regions including dorsal anterior cingulate cortex posterior cingulate cortex temporoparietal junction inferior parietal lobule preferentially recruited response mundane inconsistencies behavior results shed light distributed systems supporting impression updating specifically many regions supporting updating may primarily respond moment moment changes behavior subset regions vlpfc ifg may contribute updating person representations response trait relevant changes behavior
karlsruhe institute technology kit developing continuously working non cryogenic pumping solution torus exhaust pumping demonstration power plant demo including direct internal recycling dir full pumping system consists three pumps namely metal foil pump gas separation linear diffusion pump primary pump liquid ring pump backing pump latter two pumps apply mercury working fluid due perfect tritium compatibility asks baffle system sides pumping train control working fluid vapour avoid mercury propagation machine paper arrangement torus pumps required power plant reactor well corresponding infrastructure effect demo machine design presented discussed full pumping process called karlsruhe liquid metal based pumping process fusion reactor exhaust gases kalpurex process patent pending karlsruhe institute technology published elsevier rights reserved
proven reasonably accurate monitoring current conditions equipment required switching common scheduled maintenance condition based maintenance known instrument solving task vibration diagnostics paper provides typical examples failure diagnostics rotating electric equipment installed existing process facilities considers diagnostics failure caused mechanical defects pump analysis direct vibration spectrum bearing assemblies electric motor enabled revealing progressing defects coupling flanges second type malfunctions rotor equipment connected ball journal bearing defects defect detected spectral vibration analysis paper also describes example diagnostics asynchronous motor rotor timely detection defects squirrel cage rods prevented emergency results vibration diagnostics condition oil pumps transformer cooling system provided methods spectral diagnostics formed basis condition detection paper substantiates vibration characteristic levels determining degree force impacts transformer tank surface considers measuring procedure portable vibration analyzer reporting form
tendon drives widely used robotics compliance tendon drives suits soft robots including soft wearable robots several issues impede use generally tendon always maintain tension prevent derailment spool however soft robots tendon tension induces high friction forces owing absence ball bearings kinematics soft robot basically nonlinear changed deformation structure kinematic difference soft structure spool causes derailment tendon moreover continuously maintained tension soft wearable robots causes safety issues linear actuator option however need increase length linear actuator accommodate excursion length tendon barrier use small scale applications preclude issue slack enabling actuator employs spool proposed space efficiency spool enables mechanism small one way clutch applies unidirectional friction force tendon tighten tendon around spool paper describes design concept slack enabling mechanism design optimization system identification force control
rosmarinus officinalis medicinal herb labiates family reported potential benefit treatment prevention several diseases particular phenolics demonstrated protective effects various types cancer several mechanisms present study aimed determine effects rosemary phenolic extracts human cell functions particular regard anti proliferative properties three cell types caco peripheral blood mononuclear cells pbmcs radical scavenging ferric reducing abilities extracts assessed well cyto toxicity effects cell cycle distribution apoptosis compounds identified dominance rosmarinic acid methanolic extract phenolic diterpens ethyl acetate fraction carnosol carnosic acid methyl carnosate total polyphenolic content important first extract gallic acid equivalent compared methanolic fraction displayed higher antioxidant activity dpphic frap mmol ethyl acetate showed pronounced antiproliferative effects respectively caco cells anti proliferative effect associated cell cycle arrest phase population concomitant decrease phases tested extracts displayed addition early apoptotic effects late apoptosis caco cells obtained data indicate identified phenolics least partially responsible observed cytotoxicity
paper investigates current automatics methods used generate efficient accurate signatures create countermeasures attacks polymorphic worms strategies include autograph polygraph simplified regular expression sre rely network based signature detection filtering content network traffic signature generated methods read intrusion prevention systems firewalls paper also present architecture evaluation method implementation used patterns sre mechanism extract accurate signatures implementation accomplished use needleman wunsch algorithm inadequate manage invariant parts distances restrictions polymorphic worm consequently enhanced contiguous substring rewarded ecsr algorithm developed improve result extraction needleman wunsch algorithm generate accurate signatures signature generation sre found accurate efficient preserves important features polymorphic worms evaluation results show signature contains conjunctions tokens token subsequence produce loss vital information ignoring one byte token neglecting restriction distances furthermore simplified regular expression needs updated accurate compared autograph polygraph methods elsevier rights reserved
paper authors argue video games offer unique pervasive opportunities children develop social dispositions necessary succeed century end discuss design tavcats virtual role playing game aimed engage children ages understanding acting upon coming value caring compassionate authors discussion takes form design narrative explain connections theoretical commitments design decisions specifically review four design elements utilized design work identity claims boundary objects profession trajectories cyclic gameplay authors briefly share observations pilot study children afterschool setting illustrate design work might realized world conclude paper discussion implications work designing educational video games supporting social dispositions well academic learning future directions
paper present new model reference adaptive control mrac flight control fixed wing unmanned aerial vehicle uav uncertainties disturbance beginning new algorithm design combining direct mrac indirect adaptive control called composite mrac cmrac aspect direct mrac substitute luenberger like reference model typical one namely adding error feedback term indirect part use reverse filter filter system input kind combination results smooth transient performance extremely small tracking error addition design adaptive laws sigma modification improve robustness presence disturbances stability closed loop system formally proven using lyapunov theory effectiveness proposed algorithm also illustrated simulations longitudinal dynamics uav
crystallization struvite fluidized bed crystallizer fbc performed treat synthetic wastewaters contain phosphorous optimal conditions molar ratio struvite seed dose total flow rate min reflux min removal phosphate crystallization ratio respectively based thermodynamic prediction supersaturation obtained difference theoretical solubility phosphate concentration predominated crystallization efficiency properties struvite pellets morphology particle size apparent density coexisting ions ppm chcooh ppm ppm sot ppm utilized prepare containing wastewaters ions ppm remarkably reduced capability fbc remove phosphate solution presence chcoo synthesizing tft lcd wastewater synthesizing semiconductor wastewater lower pure water although ultimate differ significantly elsevier ltd rights reserved
renewable energy resources increasingly employed new electric power sources however stochastic uncertain behavior negatively influences power system stability paper hybrid system composed pmsg based wind farm marine current farm used supply network load resources connected nine bus power system line commutated hvdc link new control method proposed enhance damping characteristics power system method based generalized predictive control gpc design inverter current regulator icr hvdc link regard bat search algorithm employed obtaining best solution gpc objective function order demonstrate effectiveness proposed gpc bat method simulations using eigenvalue analysis root loci technique presented investigating efficiency conducted approach pid controller designed controlling icr hvdc link results compared gpc bat method comparisons made three phase short circuit fault multi machine power system matlab software evaluations clearly show effectiveness superiority proposed approach elsevier ltd rights reserved
background excessive bodyweight contributes myriad risk factors chronic diseases multiple reports demonstrated parents influence development children behaviors contribute bodyweight however studies include considerations cultural influences limited methodology considers direct reports young adults parents across cultures exist methods sample young adults parents china recruited completed series questionnaires two cycles correlation multiple regression analyses parents characteristics behaviors parental authority styles examined compared weight related health behaviors bodyweight young adult children additionally similarities differences parental influences two cultures explored results parents body mass indexes bmis dietary behaviors positively associated young adult children mixed culture sample controlling gender high levels authoritarian permissive parental authority relationships young adults parents bmis negative participants positive chinese participants high levels authoritarian parenting relationship young adults parents dietary consumption behaviors negative participants positive chinese participants conclusions study provides evidence development life long health behaviors contribute bmi significantly influenced parents behaviors parenting styles moreover interaction parental characteristics cultural norms indicated
paper integrable higher order nonlinear schrodinger equation density modulated quantum condensate investigated based ablowitz kaup newell segur system infinite number conservation laws obtained introducing auxiliary function derive bilinear forms construct dark soliton solutions help hirota method symbolic computation dark one two three solitons analyzed graphically via asymptotic analysis interactions two dark solitons proved elastic see coefficients equation affect soliton velocity analyze linear stability plane wave solutions presence small perturbation
aim study design navigation system composed human controlled leader vehicle follower vehicle follower vehicle automatically tracks leader vehicle system human driver control two vehicles efficiently agricultural operations tracking system developed leader follower vehicle control follower performed using camera vision system stable accurate monocular vision based sensing system designed consisting camera rectangular markers noise data acquisition reduced using least squares method feedback control algorithm used allow follower vehicle track trajectory leader vehicle proportional integral derivative pid controller introduced maintain required distance leader follower vehicle field experiments conducted evaluate sensing tracking performances leader follower system leader vehicle driven average speed case linear trajectory tracking rms errors straight turning zigzag paths respectively parallel trajectory tracking root mean square rms errors found straight turning zigzag paths respectively navigation performances indicated autonomous follower vehicle able follow leader vehicle tracking accuracy found satisfactory therefore developed leader follower system implemented harvesting grains using combine leader unloader autonomous follower vehicle
shoreline monitoring essential integrated coastal zone management iczm provides necessary information needed manage settlement coastal areas establishes guidelines management socioeconomic activities within coastal areas provides information necessary recovery actions beach regeneration provides reference baseline studies related climate change coastal zones shoreline monitoring methods largely dependent goals costs implementation applicability monitoring short coastal shorelines tens hundreds kilometers global navigation satellite system gnss based methods emerging low cost approaches offer rapid weather independent quickly updatable products could benefit policy makers high costs traditional methods photogrammetry remote sensing concern however various gnss methods applicable shoreline monitoring exist making difficult decision makers choose suitable approach using case study pernambuco state iczm brazil study evaluates three commonly used gnss based shoreline monitoring methods relative kinematic real time kinematic rtk precise point positioning ppp methods also provides comprehensive analysis strengths limitations results highlight issues important considerations choosing economically viable gnss method mapping shoreline changes particularly supporting iczm policies
mitochondrial dysfunction common hallmark aging female reproductive senescence characterized loss ovarian hormones many whose neuroprotective effects converge upon mitochondria functional integrity mitochondria dependent membrane fatty acid phospholipid composition also affected aging effect long term ovarian hormone deprivation upon mitochondrial function putative association changes mitochondrial membrane lipid profile hippocampus area primarily affected aging highly responsive ovarian hormones unknown aim wistar adult female rats ovariectomized sham operated twelve weeks later different parameters mitochondrial function uptake atp production membrane potential respiratory complex activities well membrane phospholipid content composition evaluated hippocampal mitochondria chronic ovariectomy reduced mitochondrial uptake atp production rates induced membrane depolarization active respiration without altering activity respiratory complexes mitochondria membrane lipid profile showed changes cholesterol levels higher levels unsaturated fatty acids higher peroxidizability index mitochondria ovariectomized rats interestingly ovariectomy also reduced cardiolipin content altered cardiolipin fatty acid profile leading lower peroxidizability index conclusion chronic ovarian hormone deprivation induces mitochondrial dysfunction changes mitochondrial membrane lipid profile comparable aging phenotype study provides insights ovarian hormone loss induced early lipidomic changes bioenergetic deficits hippocampus may contribute increased risk alzheimer disease age associated disorders observed postmenopause
novel generic method silica supported catalyst system generation fluid state presented technique based combined flow radiation microwave thermal induced assembly support catalyst precursors forming nano reactors followed catalyst precursor decomposition transformation precursor supported catalyst oxide state controlled seconds several minutes resulting nano structured micro porous silica supported catalyst system surface area approaching ray diffraction xrd based catalyst size controlled range catalyst structure appears lamellar sheets sandwiched catalyst support catalyst characteristics dependent primarily processing history well catalyst studied catalyst support molar ratio typically addition used catalysts evaluation mechanism catalyst generation based extensive xrd scanning electron microscopy sem transmission electron microscopy tem studies micro nano structure catalyst system evaluated found catalyst silica support form extensive thick lamellar sheets planar dimensions lamellae alternate silica support catalyst layer appear form bar code structure lamellae structures pack form walls micro porous catalyst system typically density tentative mechanism catalyst nano structure formation provided based rheology fluid mechanics catalyst support precursor fluid well assembly nano reactor formation processing order achieve structures characteristics catalyst support must form silane coated silica nano particles dispersed water also contains catalyst precursor nitrate salt support catalyst precursor fluid must sufficiently low viscosity high elastic modulus high extensional viscosity form films bubbles exposed processing energy sources microwave thermal ultra sound radiation combination micro nano structures catalyst system essentially formed early stage energy input shown primary particles silica transformed proto silica particle state form lamellar structures catalyst precursor nano structure forming water evaporated leaving highly porous solid support catalyst precursor undergoes decomposition form silica catalyst oxide system final catalyst system obtained catalyst oxide reduction although xrd based catalyst size changes slightly subsequent heat treatments nano structure catalyst system remains substantially unaltered evaluated tem images however catalyst preparation carried without film formation xrd based catalyst size increases substantially factor significant alteration surface area
paper describes use simulation supporting system design improving manufacturing performance ford powertrain operations manufacturing engineering division simulation modelling engine assembly lines carried using ford assembly simulation tool fast excel based front end user interface witness simulation system fast component based simulation system enables engineers non simulation experts develop engine assembly models easily quickly model building also enhanced use specialised sub models witness modules assembly line models automatically built using witness shell imports data excel data sheets produces witness elements populates elements relevant data importance quality input data sources emphasised models generally verified using expected cyclic throughput values validated real manufacturing data shop floor validated models used assess enhance performances engine assembly lines
present study provides norms deese roediger mcdermott drm lists used create false memories native speakers italian word lists reported article based drm lists used extensively examine illusory memories english speakers deese journal experimental psychology roediger mcdermott journal experimental psychology learning memory cognition translated critical lures english drm lists created semantically associated italian word lists normed native italian speakers overall participants recalled list items critical lures word lists developed addition list items critical lures recognized participants present study provides set italian lists used researchers interested evaluating false memories italian speaking participants
study aimed assess levels cell activating factor tumor necrosis factor family baff proliferation inducing ligand april cerebrospinal fluid csf patients anti methyl oaspartate receptor nmdar encephalitis determine correlation clinical outcome baff april concentrations csf serum patients anti nmdar encephalitis controls measured enzyme linked immunosorbent assay elisa compared controls levels baff april csf significantly increased patients anti nmdar encephalitis patients unfavorable outcome higher levels baff april csf favorable outcome baff april levels csf elevated associated clinical outcome patients anti nmdar encephalitis indicating may valuable biomarkers disease elsevier rights reserved
background gestational diabetes mellitus gdm associated short long term adverse health consequences mother offspring aim study prevalence risk factors gdm beijing methods study population consisted pregnant women attending prenatal care hospitals beijing delivered june november weeks gestation participants selected cluster sampling hospitals identified random systematic sampling based number deliveries questionnaire designed collect information results total women diagnosed gdm diabetes pregnancy dip age family history diabetes mellitus prepregnancy body mass index bmi bmi gain weeks maternal birth weight fasting plasma glucose first prenatal visit identified risk factors gdm women birth weight gdm rate significantly higher conclusions one every five pregnant women beijing either gdm dip constitutes huge health burden health services prepregnancy bmi weight gain week important modifiable risk factors gdm ensuring birth weight may help reduce risk future gdm among female offsprings
purpose muscarinic receptor mediated contractions detrusor rely influx voltage gated channels knowledge mechanism linking stimulation mrs activation voltage dependent channels established trpc channels receptor operated cation channels couple muscarinic receptor activation depolarization intestinal smooth muscle cells voltage activated influx contraction investigated whether trpc channels involved cholinergic mediated contractions detrusor materials methods isometric tension recordings made strips murine detrusor intracellular measurements made isolated detrusor myocytes using confocal microscopy transcriptional expression trpc ipr subtypes intact detrusor strips isolated detrusor myocytes assessed using reverse transcriptase polymerase chain reaction results cholinergic stimulation detrusor induced electrical field stimulation exogenous application carbachol neostigmine evoked contractions consisting transient plus tonic response blocked inhibitor trpc channels phasic oscillatory component blocked ipr inhibitor apb carbachol evoked reproducible responses isolated detrusor myocytes consisting initial transient followed oscillations inhibited initial transient whereas apb inhibited oscillations reverse transcriptase polymerase chain reaction experiments showed trpc beta trpc selectively expressed isolated detrusor myocytes control experiments demonstrated affect type current amplitude caffeine induced transients kcl induced contractions detrusor conclusions muscarinic receptor mediated contractions detrusor involve activation trpc beta channels
popularity software defined networks sdn openflow increases policy driven network management received attention manual configuration multiple devices replaced automated approach software based network aware controller handles configuration network devices software applications running top network controller provide abstraction topology facilitate task operating network propose opensec openflow based security framework allows network security operator create implement security policies written human readable language using opensec user describe flow terms openflow matching fields define security services must applied flow deep packet inspection intrusion detection spam detection etc specify security levels define opensec reacts malicious traffic detected paper first provide detailed explanation opensec converts security policies series openflow messages needed implement policy second describe framework automatically reacts security alerts specified policies third perform additional experiments geni testbed evaluate scalability proposed framework using existing datasets campus networks results show attacks existing data set detected malicious source nodes blocked automatically furthermore show policy specification language simpler offering fast translation times compared existing solutions
backgroundanagrelide represents treatment option essential thrombocythemia although place therapy remains controversial aimto assess impact mutational status response rates development adverse events long term use anagrelide methodswe retrospectively evaluated patients essential thrombocythemia treated anagrelide months resultsmutational frequencies jakvf calr mpl mutations anagrelide yielded high rate hematologic responses complete partial without differences among molecular subsets rate thrombosis treatment one per patient years without excess bleeding anemia major adverse event follow frequent calr pmonths higher risk indicating need bone marrow monitoring prolonged treatment conclusionalthough calr patients higher risk developing anemia anagrelide proved effective among molecular subsets indicating mutational status seem represent major determinant choice cytoreductive treatment among essential thrombocythemia therapies
role subclinical infection patients urge incontinence largely ignored aim study test presence intracellular bacteria exfoliated urothelial cells obtained urine patients detrusor overactivity mixed incontinence history uti compare control group patients stress incontinence history infection bacterial cystitis assessed routine microbiology compared microscopic analysis urine wright staining subsequent analysis urothelial cells confocal microscopy performed determine existence intracellular bacteria bacterial cystitis seen patients based routine microbiology wright staining concentrated urothelial cells demonstrated presence bacteria samples filamentous bacterial cells observed patients significantly common patients detrusor overactivity intracellular escherichia coli observed confocal microscopy study supports possibility subset patients urge incontinence may unrecognised chronic bacterial colonisation maintained via intracellular reservoir patients negative routine microbiology application techniques used study revealed evidence infection providing insights aetiology urge incontinence study shows evidence intracellular bacteria cells lining bladder patients urge incontinence providing insights underlying cause condition study shows evidence intracellular bacteria cells lining bladder patients urge incontinence providing insights underlying cause condition
ongoing deployment residential smart meters numerous jurisdictions led influx electricity consumption data information presents valuable opportunity suppliers better understanding customer base designing effective tariff structures past various clustering methods proposed meaningful customer partitioning paper presents novel finite mixture modeling framework based vine copulas cvmm carrying consumer categorization superiority proposed framework lies great flexibility pair copulas toward identifying multidimensional dependency structures present load profiling data cvmm compared classical methods using real demand measurements recorded across households london smart metering trial superior performance proposed approach demonstrated analyzing four validity indicators addition decision tree classification module partitioning new consumers developed improved predictive performance cvmm compared existing methods highlighted case studies carried based different loading conditions different sets large numbers households demonstrate advantages test scalability proposed method
purpose randomized controlled trials claims databases suggest antiepileptic drug aed use may increase risk suicide attempts present case control study explores impact underlying indications potential association methods physicians collected medical history prior month drug use obtained standardized telephone interviews patients association aed use explored using multivariate conditional logistic regression analyses replicated stratification depression neurological disorders epilepsy migraine chronic neuropathic pain results adults incident recruited suicide treatment centers across france socio demographically matched controls primary care settings association aed use odds significant overall odds ratio confidence interval association observed patients neurological disorders opposed patients depression unmeasured confounding suspected conclusions results suggest association observed aed use increased odds non fatal patients either lifetime history depression neurological disorder may explained presence underlying psychiatric disorder accounting underlying indications crucial drug safety studies cause reported association lack thereof misleading may require prospective collection medical data patient level copyright john wiley sons ltd
present study represents connection basic science clinical applied science providing bioanalytical method analysis certain administered drugs used treatment rheumatoid arthritis studied drugs esomeprazole leflunomide ibuprofen proposed bioanalytical method simple reversed phase high performance liquid chromatographic method using micellar mobile phase method conducted using shim pack ods mmx stainless steel column ambient temperature ultraviolet detection micellar mobile phase consisted sodium dodecyl sulfate propanol triethylamine orthophosphoric acid pumped flow rate min calibration curve rectilinear concentration range esomeprazole leflunomide ibuprofen respectively proposed method successfully applied analysis drugs dosage forms method extended vitro vivo determination drugs spiked real human plasma samples
present study investigated effect participants mood true false memories emotional word lists deese roediger mcdermott drm paradigm experiment constructed drm word lists studied words corresponding critical lures reflected specified emotional valence experiment used lists assess mood congruent true false memory participants randomly assigned one three induced mood conditions positive negative neutral presented word lists comprised positive negative neutral words true false memory mood congruent effect negative mood condition effect due decrease true false recognition positive neutral words findings consistent spreading activation fuzzy trace theories drm performance practical implications understanding effect mood memory
paper operational amplifier general purpose presented unified current control model used synthesize standard two stage topology based circuit design procedure discussed thoroughly every step explained details results obtained include open loop gain gain bandwidth product mhz phase margin higher degrees supply voltage temperature coefficients analyzed discussed within paper process variations investigated corner analysis results presented obtained schematic level simulations using spectre simulator cadence design system standard cmos technology process
background giardiasis common enteric parasitic infection united states causes estimated million episodes illness annually published clinical recommendations include readily available giardia specific diagnostic testing antiparasitic drugs investigated sequences giardiasis diagnostic treatment events using marketscan large health insurance claims database methods created longitudinal cohort persons diagnosed giardiasis international classification diseases ninth revision clinical modification icd code analyzed claims occurring days days initial diagnosis evaluated differences number sequence visits diagnostic tests prescriptions age group children years adults years using chi tests data visualization software results among patients claims giardia specific test followed concurrent effective antiparasitic drug without ineffective antibiotics almost two thirds patients antiparasitic antibiotic study window compared children adults often visits diagnosis adults also less likely giardia specific diagnostic test likely antibiotic prescription giardia specific tests antiparasitic antibiotic prescriptions examined pediatric clinical event sequences frequently began giardia specific test whereas adult sequences frequently began antiparasitic prescription conclusions giardiasis care infrequently follows aspects clinical recommendations multiple differences pediatric adult care despite age agnostic recommendations suggest opportunities provider education tailored guidance
paper investigate dimensional toda sasa fukuyama equation interfacial wave two layer liquid elastic quasiplane wave lattice bell polynomials symbolic computation hirota method one two bell soliton solutions derived backlund transformation presented parallel collision two solitons exists soliton directions oblique collision appears two solitons different soliton directions published elsevier ltd
objective evaluate effect guizhi gancao longgu muli tang gglmt decoction prepared herbal medicine traditional chinese medicine sleep disturbances women menopause methods totally participants recruited treatment sleep difficulty february december decoction taken every participant twice daily half hour lunch dinner two weeks sleep quality assessed pittsburg sleep quality index psqi menopausal symptoms quality life evaluated menopause rating scale mrs chinese version world health organization quality life bref final fellow fourth weekend beginning results average scores psqi reduced week gglmt treatment fourth week gglmt improved symptoms patients severe conditions mrs three adver drlig reaction mouth ulcer constipation folliculitis might related gglmt disappeared withdrawals treatment conclusion menopausal women suffering chronic sleep disturbances findings suggest two weeks treatment gglmt safe effective jtcm rights reserved
unique course named introduction engineering design recently developed implemented technion israel institute technology course allows top grade students majoring science engineering experience engineering design end course students plan implement team basis real time control system electric motor course intended increase graduates motivation science engineering develop systems thinking skills train teamwork skills assist future engineering work study described paper examined quantitative qualitative tools degree course first two objectives attained thirty two students participated study findings indicate improvement students intrinsic motivation study science engineering medium effect size systems thinking skills large effect size
light regime variability important limiting factor constraining tree growth tropical forests however considerable debate whether radiation induced green dry season real apparent artifact remote sensing techniques used infer seasonal changes canopy leaf area direct widespread observations vertical canopy structures drive radiation regimes largely absent analyze seasonal dynamic patterns canopy understory layers amazon evergreen forests using observations vertical canopy structure spaceborne lidar discovered net leaf flushing canopy layer mainly occurs early dry season followed net abscission late dry season coincides increasing leaf area understory layer observations understory development lidar either weakly respond correlated seasonal variations precipitation insolation strongly related seasonal structural dynamics canopy layer hypothesize understory growth driven increased light gaps caused seasonal variations canopy light regime variability exists spatial temporal domains better reveal drought induced green phenomenon appears less obvious treating amazon forests whole
non intrusive observations fundamental monitor river flows understand water processes natural systems recently introduction optical methods fostered establishment numerous image based techniques characterizing kinematics water bodies however rgb image based methods still severely affected illumination conditions tracers visibility note integration particle shaped tracers thermal imagery applied characterize surface velocity field natural stream specifically trajectories grams artificially deployed ice dices reconstructed analyzing thermal images particle tracking velocimetry average surface flow velocities agreement benchmark values estimated current meter proof concept experiment demonstrates efficacy thermal imagery hydrological monitoring paves way integration thermal signals standard water gauging systems international association hydro environment engineering research asia pacific division published elsevier rights reserved
water precious resource demand rising rapidly already exceeded supply capacity natural sources many cities airports spread vast areas normally free birds pollution thus offer immense opportunities rainwater harvesting could large extent meet non potable water requirements article reviews rainwater treatment procedures various airports provide valuable resource consumption also prevent entry pollutants directly environment also discusses models approaches assess rainwater harvesting potential airports parameters cost reliability explains stages involved rainwater harvesting systems airports implemented rainwater treatment systems finally identifies gaps various stages discusses possible improvements near future
system identification methods widely used study low frequency electromechanical oscillations development low order dynamic models paper introduces hybrid frequency time domain approach estimate dominant modes contained ringdown responses power systems practical issues solutions encountered application hybrid method discussed performance proposed technique evaluated applying monte carlo method synthetic signals simulated responses large scale power system well measurements recorded microgrid laboratory test facility results cases proved accurate verifying robustness proposed method
paper explore possibilities offered integration home automation systems service robots particular examine advanced computationally expensive services provided using cloud computing approach overcome limitations hardware available user home end integrate two wireless low cost shelf systems work namely service robot rovio home automation system wave cloud computing used enhance capabilities systems advanced sensing interaction services based image processing voice recognition offered
background increasing prevalence childhood obesity worldwide become public health issue many factors involved development obesity stress pregnancy linked adiposity however research involving stressors independent pregnant women socioeconomic psychological characteristics rare present study made use natural disaster quebec ice storm determine aspect women disaster experience objective hardship subjective stress cognitive appraisal associated body mass index levels waist height ratio across childhood adolescence methods measure objective hardship subjective stress cognitive appraisal obtained following quebec ice storm measured height weight waist circumference children ages results results show higher prenatal maternal stress associated higher body mass index levels central adiposity children ages effects prenatal maternal stress anthropometric measurements tend increase children grew older discussion findings study highlight long lasting effect prenatal stress body composition compatible current theory fetal programming hopefully increased knowledge effects prenatal stress fetus lead improved awareness creation early intervention programs ultimately improving women children health future elsevier inc rights reserved
despite progress perceptual tasks image classification computers still perform poorly cognitive tasks image description question answering cognition core tasks involve recognizing reasoning visual world however models used tackle rich content images cognitive tasks still trained using datasets designed perceptual tasks achieve success cognitive tasks models need understand interactions relationships objects image asked vehicle person riding computers need identify objects image well relationships riding man carriage pulling horse carriage answer correctly person riding horse drawn carriage paper present visual genome dataset enable modeling relationships collect dense annotations objects attributes relationships within image learn models specifically dataset contains images image average objects attributes pairwise relationships objects canonicalize objects attributes relationships noun phrases region descriptions questions answer pairs wordnet synsets together annotations represent densest largest dataset image descriptions objects attributes relationships question answer pairs
important pre processing stage many machine learning pattern recognition domains feature selection deems identify discriminate features compact data representation typical feature selection methods lasso variants using norm based regularization received much attention recent years however existing norm based sparse feature selection methods ignore structure information data consider pairwise relationships among samples paper propose hypergraph regularized sparse feature learning method high order relationships among samples modeled incorporated learning process specifically first construct hypergraph multiple hyperedges capture high order relationships among samples followed computation hypergraph laplacian matrix propose hypergraph regularization term hypergraph regularized lasso model conduct series experiments number data sets uci machine learning repository two real world neuroimaging based classification tasks experimental results demonstrate proposed method achieves promising classification results compared several well known feature selection approaches
paper nonlinear systems time delay network control discussed transmission delays packet dropouts networked control system random time delay analyzed paper online delay estimation method obtain delay value delay value input parameter fuzzy adaptive pid controller fuzzy pid temporal adjustment based genetic algorithm particle swarm optimization algorithm optimization objective function three parameters pid adjusted online order improve system stability matlab simulation tool true time shows fuzzy logic control system base pso algorithm promote reduce transmission delays packet dropouts paper also shows superiority fuzzy pid controllers traditional pid ncs applications
modifying bismuth vanadate bivo photoanode secondary component promising strategy improving performance photoelectrocatalytic water oxidation herein investigate polyoxometalates poms molecular doping bivo photoanodes improve photoelectrocatalytic water oxidation performance bivo water oxidation performance bivo poms photoanodes markedly enhanced comparison pristine bivo photoanode moreover improved photoelectrocatalytic performance bivo poms composite photoanodes clearly relevant type amount poms mechanism photogenerated electron transfer bivo poms also revealed photoluminescence spectroscopy surface photovoltage measurements mechanism suggests introduction poms capable facilitating charge separation transport well retarding electron hole recombination elsevier rights reserved
high dimensionality classification imbalanced data sets two interesting machine learning challenges issues independently studied literature order simultaneously explore issues feature selection oversampling efficiently combine two different methodological approaches unified kernel framework specifically proposed novel norm balanced multiple kernel feature selection mkfs designed proximal based optimization algorithm efficiently learning model moreover multiple kernel oversampling mkos developed generate synthetic instances optimal kernel space induced mkfs compensate class imbalanced distribution experimental results multiple uci data two real medical application demonstrate jointly operating nonlinear feature selection oversampling norm multi kernel learning framework mkfsos lead promising classification performance
long non coding rnas lncrnas implicated many tumors find novel targets study diffuse large cell lymphoma dlbcl team performed genome wide analyses lncrna expression dlbcl cell lines using agilent lncrna chip system normal cells five lncrnas validated quantitative reverse transcription polymerase chain reaction differentially expressed lncrnas mrnas identified via false discovery rate fold change filtering potential targets correlated dlbcl recognized via gene ontology pathway analysis establishment expression network done using cytoscape total lncrnas mrnas dysregulated dlbcl cells comparing normal cells results suggested expressions lncrnas consistent chip results several terms including cell cycle apoptosis cell receptor kappa signaling pathways important progression dlbcl chromosome locations lncrnas associated coexpressed genes demonstrated cis regulatory gene analyses results trans analyses showed multiple transcription factors regulated lncrna gene expression outstanding lncrnas group implicated regulation lncrna target gene network study identified set lncrnas differentially expressed dlbcl cells
patients essential thrombocythemia suffer thrombotic complications main source mortality due complex pathogenesis existing single laboratory method able identify patients highest risk developing thrombosis twenty patients essential thrombocythemia diagnosis healthy volunteers patients treated hydroxyurea compared regard certain rotation thromboelastometry parameters clotting time clot formation time cft angle maximum clot firmness mcf assessed using intem extem fibtem natem tests patients essential thrombocythemia diagnosis demonstrated significantly higher mean platelet count markedly lower mean red blood count controls cft readings found markedly lower essential thrombocythemia patients diagnosis control group according extem test patients diagnosis markedly lower values extem fibtem patients hydroxyurea therapy alpha angle values markedly higher essential thrombocythemia patients diagnosis controls according extem fibtem natem tests mcf readings significantly higher essential thrombocythemia patients diagnosis controls according extem intem fibtem natem tests patients hydroxyurea therapy markedly lower mcf values according extem test patients diagnosis patients essential thrombocythemia demonstrate prothrombotic state time diagnosis reflected changes certain rotation thromboelastometry parameters hydroxyurea therapy induces downregulation prothrombotic features seen essential thrombocythemia patients diagnosis copyright wolters kluwer health inc rights reserved
study modern microgrids implicitly comes concern quality power impact electrical network result accumulated impact nonlinear processes many include switching elements perform microgrid studies especially simulations test smart control techniques strategies ideal sinusoidal waveforms valid assumption harmonic components must correctly represented paper intends present voltage current signals based lumped models harmonic electrical loads suitable simulation environment corresponding computations required harmonic powers load also presented calculations done could used obtain quantitative estimation harmonics contexts large built environments microgrids significant nonlinear processes chemical loads
functional connectivity alterations represent key feature alzheimer disease provide useful tool characterize predict course disease alterations also described mild cognitive impairment mci prodromal stage growing interest detecting pathology brain early stages disorder subjective cognitive decline scd could represent preclinical asymptomatic stage little known population present work assessed whether disruptions already present stage share spatial distribution properties mci alterations condition known highly related end measured electromagnetic spontaneous activity meg healthy control elders elders scd mci patients results showed alterations scd mci compared healthy control group interestingly groups exhibited similar spatial pattern altered links hyper synchronized anterior network posterior network characterized decrease decrease pronounced mci group results highlight elders scd present alterations importantly disruptions affected typically related areas showed great overlap alterations exhibited mci patients results support consideration scd preclinical stage may indicate alterations appear early course disease
subject consideration gyroscope mounted gimbal cardan suspension placed immovable foundation field gravity dissipative control torques axes gimbals supposed absent fast rotating rotor action frictional torque device supplied asynchronous electric motor forms driving torque acting axis rotation rotor inner gimbal inner gimbal serves stator motor device family steady motions steady precessions rotor outer gimbal axis steady rotations rotor axis rotation inner gimbal paper global attraction property proved set steady motions means every motion device tends one steady motions time tends infinity outcomes numerical simulation presented give demonstration property
well known multipath effect remains dominant error source affects positioning accuracy global navigation satellite system gnss receivers significant efforts made researchers receiver manufacturers mitigate multipath error past decades recently multipath mitigation technique using dual polarization antennas become research hotspot provides another degree freedom distinguish line sight los signal los multipath composite signal without extensively increasing complexity receiver numbers multipath mitigation techniques using dual polarization antennas proposed report performance improvement single polarization methods however due unpredictability multipath multipath mitigation techniques based dual polarization always effective studies discuss condition multipath mitigation using dual polarization antenna outperform using single polarization antenna fundamental question dual polarization multipath mitigation dpmm design multipath mitigation algorithms paper analyze characteristics signal received dual polarization antenna use maximum likelihood estimation mle assess theoretical performance dpmm different received signal cases based assessment answer fundamental question find dual polarization antenna capability mitigating short delay multipath challenging one among types multipath majority multipath mitigation techniques considering effective conditions propose dual polarization sequential iterative maximum likelihood estimation simle algorithm dpmm simulation results verify theory show superior performance proposed simle algorithm traditional one using rhcp antenna
torque fill capability gearshifts important customer requirement automated transmission systems functionality achieved transmission system layouts based dual clutch technology characterized significant mechanical complexity hence relatively high cost mass paper describes parallel hybrid electric drivetrain concept based integration electric motor drive relatively simple six speed automated manual transmission resulting hybrid electric drivetrain actuates torque fill function control electric motor torque gearshifts engine side drivetrain optimal controller based line computation control gain profiles presented clutch engagement phase novel controller allows computationally efficient consideration clutch energy dissipation clutch engagement phase gearshift performance optimal controller contrasted two conventional clutch engagement controllers along set gearshifts simulated experimentally validated vehicle model authors published elsevier ltd
today data centers supporting internet scale computing input output services increasinglymore network intensive applications deployed network service end critical applications quickly retrieve requests network send responses network facilitate network function operating system usually provides event notification mechanism applications library know network ready supply data read receive data write widely used representative notification mechanism epoll linux provides scalable high performance implementation allowing applications specifically indicate connections events need watched epoll used major systems including key value systems redis memcached web server systems nginx identified substantial performance issue use sake efficiency applications usually use epoll system calls inform kernel exactly events interested always keep information date however system demanding network traffic rigid maintenance information necessary excess number system calls purpose substantially degrade system performance paper use redis example explore issue propose strategy informing kernel interest events manner adaptive current network load epoll system calls reduced events efficiently delivered implemented event polling library named flexpoll purely user level without modifying kernel code evaluation redis shows query throughput improved micro benchmarks even workloads emulating real world access patterns flexpoll generic mechanism thus adopted applications straightforward manner nginx memcached
road authorities developing countries recognize need maintain unpaved roads rural areas using local resource based approaches rather attempting meet international standards authors developed novel road maintenance technique call nou since demonstrated technique asia pacific africa latin america nou classified geotextile used reinforce shear strength soil using plastic crop bags widely available developing countries unskilled local labor modification technique also applied maintenance unpaved roads clayey ground construction retaining walls road embankment flood prone areas demonstrated practical communities maintain unpaved roads rural areas equipped nou technique thereby enhancing community resilience kenyan government recognized donou technique road strategy plan invested training youth technique employment promotion authors published elsevier ltd
background mild hypothyroidism thyroid stimulating hormone tsh less miu induces reversible cognitive dysfunction evaluated event related potentials erp far little known impact subclinical hypothyroidism erp electrophysiological markers cognitive activity aim study follow latencies amplitudes patients subclinical hypothyroidism evaluate influence thyroxine treatment led normalization tsh level serum methods recorded wave using auditory oddball paradigm patients mean age years range years subclinical hypothyroidism normal mean value elevated tsh levels baseline months months healthy control subjects patients treated six months thyroxine normalization tsh patients received placebo results latencies patients subclinical hypothyroidism significantly longer amplitudes significantly smaller control group thyroxine treated patients latency continuously decreased observation period significant difference months compared baseline amplitude showed significant changes time conclusions results show importance event related potentials detection cognitive changes patients hypothyroidism latency stands marker cognitive function recovery treatment thyroxine
article deals attitude russian orthodox church human prenatal development due increase high reproductive technologies application around world including russia russian orthodox church admits necessity stating opinion human embryo value research based analysis hagiographical materials biblical texts liturgical tradition church iconography patristic heritage paper concludes russian church considers human embryo absolute value convincing evidence found hagiography instance life sergius radonezh says god chosen great man faith mother womb patristic heritage many years ago holy fathers taught child leads spiritual life mother womb athenagoras writes embryo mother womb living god care convincing proof russian church always regarded antenatal life human individual liturgical tradition among russian religious holidays holidays like nativity holy mother god john forerunner lord jesus christ also holidays conception lot monasteries cathedrals sanctified honour events biblical basis russian church proof conception beginning human life gospel luke describing meeting lady mary righteous elizabeth book psalms david king prophet says every person god creature known god even mother womb iconographic tradition knows icons conception holy mother god conception ann conception john forerunner thus russian church highly respects human life moment conception assuming embryo formed unformed true human shaped image god proof found liturgical tradition gospel narratives hagiography church iconography
kaposi sarcoma associated herpesvirus kshv latest addition human herpesvirus family unlike alpha beta herpesvirus subfamily members gamma herpesviruses including epstein barr virus ebv kshv cause various tumors humans kshv primarily infects endothelial cells vivo associated least three malignancies kaposi sarcoma two cell lymphomas respectively although kshv readily infects endothelial cells vitro thus pathogenic mechanisms extensively studied cells refractory kshv infection functions kshv genes mostly elucidated endothelial cells context viral infection cells whether kshv oncogenes defined endothelial cells play roles tumorigenesis cells remains open question recently ground breaking studies cell infection models established review models compared contrasted putative mechanisms kshv induced cell transformation discussed
patient female final diagnosis colonic malt lymphoma symptoms epigastric pain medication clinical procedure colonoscopy biopsy specialty gastroenterology hepatology objective rare disease background non hodgkin lymphoma nhl well known hematologic malignancy gastrointestinal tract commonly involved extra nodal site malt lymphomas uncommon accounting nhl gastric mucosa associated lymphoid tissue malt lymphoma prototype seen association helicobacter pylori colonic malt lymphoma rare comprises malt lymphomas etiology treatment well established case report year old hispanic woman presented clinic symptoms chronic epigastric pain past three years pound weight loss past two months patient prior medical conditions systemic examination unremarkable routine labs revealed mild anemia upper endoscopy colonoscopy colorectal cancer screening performed revealing erosive gastropathy duodenal ulcers broad based polypoid mass hepatic flexure respectively computed tomography abdomen revealed round well demarcated mass hepatic flexure colon histopathology immunophenotyping consistent extra nodal marginal zone malt lymphoma stool testing pylori positive patient received two weeks pylori eradication therapy four cycles rituximab repeat colonoscopy completion chemotherapy showed complete resolution malt lymphoma conclusions unlike gastric malt lymphoma treatment colonic malt lymphoma standardized chemotherapy surgical resection utilized successfully treat handful cases reported successful treatment colonic malt lymphoma rituximab monotherapy
objective report introduction impact non medical prescribing initiated improve patient pathways presenting dizziness balance disorders methods southport ormskirk physiotherapy led vestibular clinic sees treats patients dizziness balance disorders referred ent department letters triaged audiologist also performs otological examination hearing test followed assessment independent prescriber physiotherapist ent consultant nearby joint consultation needed diagnoses treatments patient satisfaction studied analysis impact medication management stopping starting medicines patients service results months new patients dizziness balance disorders appointments common diagnoses benign paroxysmal positional vertigo vestibular migraine eighty four per cent patients required self management strategies per cent exercise therapy per cent medication management per cent particle repositioning manoeuvre patient satisfaction high per cent conclusion independent prescriber physiotherapist leading balance clinic reduced number hospital visits onward referrals nearly half patients required medication management part dizziness balance treatment
adsorption liquid solid interface widely used textile industry processes dyeing finishing wastewater treatment many others precipitates nano dimensions formed situ used form coherent usually amorphous films metal oxides sulfides etc solid surfaces including textiles phenomena successfully used polymerize pyrrole surface textile fibers fabrics yarns pyrrole particularly suitable process monomers aniline thiophene may used polypyrrole one environmentally stable conductive materials process successfully used industrial production electrical properties environmental stability product depend number variables concentration chemicals particularly dopants used furthermore environmental stability conductive textiles significantly improved use certain additives polymerization numerous applications found conductive textiles especially field microwave adsorption characteristics highly desirable case military applications like camouflage stealth technology
methanol fuel used diesel engine reduce emissions effectively performance engine keeps unchanged even improved study methanol used diesel engine paid attention experiments conducted cylinder turbocharged direct injection diesel engine fueled diesel methanol dual fuel dmdf experiment methanol injected inlet duct two low pressure injectors directly mixed intake air entering engine diesel fuel directly injected cylinder methanol substitution percent msp intake air temperature engine speed changed investigate unevenness degree ued cylinder cylinder experimental results show ued engine increases increase msp various engine loads covpp increases msp low engine load covpp curves vary little low msp engine load significantly rise appeared msp increases ued gradually increases increase intake air temperature usually less intake air temperatures lower degrees msp suggests helpful decrease ued intake air temperature range degrees msp less addition difference pressure cylinder cylinder decreases increase engine speed considered raising msp high engine speed order gain better engine economy elsevier ltd rights reserved
creation smart environments adaptive responsive context used one strongest ideas ambient intelligence also one areas seems persistent gap initial promises real achievements possible reason challenging context driven interaction systems support highly interdependent rarely designed together paper analyse implications context driven interaction type systems support provided smart environments analysis based study previous work area structured around three main dimensions interaction smart environments physical integration spontaneous interoperation application programming abstractions contributions paper fold characterization system design space according requirements raised context driven interaction identification new alternative paths integration context driven interaction smart environments
skin malignant melanoma aggressive cancer increasing incidence limited therapies advanced stages tumor associated macrophages tams major immune constituent microenvironment contribute toward prognosis tams characterization localization human cancer important understand cancer progression identify molecular personalized therapies tams stage mms associated worse prognostic parameters comprehensive macrophage macrophage intratumoral localization quantification stages skin mms documented clinical significance highlight immune pathways possible early indicators progression evaluated number tams intratumoral distribution large series skin mms double immunostaining mrp inducible nitric oxide synthase macrophages macrophages performed stage skin mms long duration follow accumulation distribution tams intratumoral nests stroma invasive front correlated clinicopathological variables since early stage mms intratumoral macrophages fewer population recruitment rapidly progressively overwhelmed increase tams progression independent intratumoral distribution accumulation tams associated poor prognostic indicators patients survival recruited macrophages shift phenotype early development possibly induced high inducible nitric oxide synthase intratumoral increase peculiarly occurring since initial stages recruited tams overwhelm accumulation stages progression thus favoring neoplastic growth dissemination independent intratumoral distribution prevalent accumulation tams statistically confirmed poor indicator patients outcome potential target immune therapies copyright wolters kluwer health inc rights reserved
purpose study validity medication adherence self report inventory masri use clinical practice treat patients benign prostatic obstruction bpo accompanied overactive bladder oab symptoms methods weeks randomized study patients bpo oab symptoms mean age studied adherence treatment tamsulosin solifenacin trospium using masri external monitoring instruments included brief medication questionnaire bmq visual remaining pill count state prostate gland lower urinary tract monitored using questionnaires pss oab awareness tool uroflowmetry voiding diaries result correlation percentage men non adherent treatment masri percentage patients belief barrier screen bmq number missed doses regimen screen bmq number non adherent patients according bmq results pill count data confirm high validity masri conclusion masri valid tool rapid assessment adherence treatment patients bpo oab receiving tamsulosin antimuscarinic drugs may recommended use clinical practice
background pustular skin disorders category difficult treat potentially life threatening conditions involve appearance neutrophil rich pustules molecular basis pustular skin conditions remained unknown objective sought investigate molecular basis pustular skin disorders generalized pustular psoriasis gpp palmoplantar pustulosis ppp acute generalized exanthematous pustulosis agep methods microarray analyses performed profile genome wide gene expression skin biopsy specimens obtained patients gpp ppp agep healthy control subjects functional enrichment gene network means clustering analyses used identify molecular pathways dysregulated patients disorders immunohistochemistry immunofluorescence used determine protein localization quantitative pcr elisa used determine transcript secreted cytokine levels small interfering rna used decrease transcript levels results molecules pathways related neutrophil chemotaxis emerged common alterations patients gpp ppp agep consistent pustular phenotypes expression two transmembrane epithelial antigens prostate steap proteins steap steap increased patients skin colocalized gamma around neutrophilic pustules steap expression clustered positively correlated family proteins cxcl steap expression activated cytokines suppressed inhibition mitogen activated protein kinase kinase whereas steap expression appeared less prone dynamic regulation importantly steap knockdown resulted impaired induction broad spectrum proinflammatory cytokines including neutrophil chemotaxins cxcl cxcl steap knockdown also reduced ability keratinocytes induce neutrophil chemotaxis conclusion transcriptomic changes pustular skin disorders gpp ppp agep converged neutrophil chemotaxis diapedesis cytokines known drive neutrophil rich inflammatory processes including members family steap steap positively regulate induction proinflammatory neutrophil activating cytokines
hearing voices present prominent symptom serious mental illness however experiences may common non help seeking population leading propose existence continuum psychosis health disease thus far research continuum focused impaired help seeking groups focus protective factors non help seeking voice hearers introduce new study population clairaudient psychics receive daily auditory messages conducted phenomenological interviews subjects well patients diagnosed psychotic disorder hear voices people diagnosis psychotic disorder hear voices matched control subjects without voices diagnosis found hallucinatory experiences psychic voice hearers similar patients diagnosed employed techniques forensic psychiatry conclude psychics malingering critically found sample non help seeking voice hearers able control onset offset voices less distressed voice hearing experiences first time admitted voice hearing reception others much likely positive patients much negative voice hearing experiences likely receive negative reaction sharing voices others first time subsequently disruptive social relationships predict sub population healthy voice hearers may much teach neurobiology cognitive psychology ultimately treatment voices distressing
background purpose physical therapists pts display positive attitudes toward evidence based practice ebp implementing improve patient outcomes reduce costs however barriers lead inconsistent use ebp objectives manuscript describe initiation revisions knowledge translation programme assess staff participation iii evaluate availability internal use external dissemination evidence based recommendations research target setting programme implemented large paediatric hospital employing pts provide services inpatient outpatient developmental sports orthopaedics settings locations development programme programme initiated years ago underwent improvements past years five key revisions included subdivision ebp research coordinator positions area practice increasing structure programme implementing strategies encourage use local recommendations obtaining leadership support emphasize providing staff education outcomes revisions staff participation local recommendation development increased research involvement increased number local recommendations increased overall compliance rate achieved recommendations presented algorithm format external dissemination increased presentations publications discussion revisions programme improved engagement activities increased availability local recommendations encouraged use ebp increased external dissemination information
density functional theory dft calculations performed investigate hydrogen adsorption surfaces different coverages found surface different hydrogen adsorption strength saturated coverages surface weakest adsorption well smallest saturated coverage thermodynamics method applied include effects temperature hydrogen partial pressure stable hydrogen coverage built phase diagram clearly revealed reaction condition dependent concentration surface theoretically predicted hydrogen desorption temperatures nice agreement available experimental results interestingly adsorption hydrogen also found able modify morphology catalyst based wulff constructions calculations provide useful information reaction mechanism calculations especially hydro treating reactions hydrogen coverage surface important roles determining adsorption configurations reactants well final reaction mechanisms elsevier rights reserved
increasing efficiency combustion engines new airpath concepts increased complexity viable case gasoline engines one promising technology two stage turbocharging closed loop control airpath concept investigated paper particular modelbased predictive control approach proposed reveals advantage taking multiple input process behaviour account compensation arising deadtime respecting turbocharger speed limits low demands calibration effort validation proposed control algorithm implemented prototyping electronic control unit tested vehicle present paper results vehicle experiments conducted chassis dynamometer demonstrated
comparison problems represent class big data processing problems widely found many application domains achieve high performance distributed computing problems storage usage data locality load balancing considered data distribution phase distributed environment existing data distribution strategies hadoop one designed problems mapreduce pattern consider comparison tasks result huge amount data must arranged runtime comparison tasks executed degrading overall computing performance significantly addressing problem scalable efficient data distribution strategy presented paper comparison tasks mind distributed computing comparison problems specifically designed problems comparison pattern saves storage space data distribution time also achieves load balancing good data locality comparison tasks comparison problems experiments conducted demonstrate presented approaches shown ideal performance capacity multiple machines achieved using approach presented paper elsevier rights reserved
paper presents results triaxial tests conducted investigation influence geotextiles stress strain volumetric change behaviour reinforced sandy soil tests carried loose sandy soil experimental program includes drained compression tests samples reinforced different values geotextiles layers confining pressure sigma two methods preparation used air pluviation moist tamping test results show geotextiles induce quasi linear increase stress deviator volume contraction reinforced sand method preparation significantly affects shear strength samples prepared air pluviation method mobilized deviator stresses significantly higher prepared moist tamping method geotextiles restrict dilation reinforced sandy soil consequently contraction increases mobilized friction angle increases increasing number layers decreases increasing initial confining pressure samples prepared moist tamping present mobilized friction angles significantly lower prepared air pluviation method samples prepared air pluviation method secant modulus epsilon decreases increasing geotextile layers prepared moist tamping method secant modulus epsilon increases increasing number geotextile layer sand confining pressure axial strain secant modulus increases increasing inclusions geotextile layers
rainwater harvesting hard roofing provide safe water meet basic domestic needs several hundred million people low income countries however rainwater harvesting higher household cost lowtechnology water supplies protected springs storage tank expensive part infrastructure required rainwater harvesting reducing cost enable rainwater harvesting become viable water source many households low income countries paper assesses overall costs different cost components rainwater storage tanks costs compared across selection tanks prefabricated factories uganda kenya constructed situ uganda constructed tanks always found cheaper prefabricated ones tank size important factor found tank cost per litre decreases size increases tank types materials greatest cost
study conducted evaluate quality stored rainwater basic schools tamale metropolis semi arid region ghana experiences persistent water scarcity sixty four stored rainwater samples collected eight rainwater harvesting facilities eight basic schools november december analysed total coliform levels ranged cfu mean cfu microbial load exceeded world health organisation limit potability heavy metal concentrations within standards except cadmium lead drinking stored rainwater deleterious health pupils basic schools studied therefore recommended potable water provided basic schools order meet millennium development goals
fruit lycium chinense miller solanaceae used functional food medicinal herb treating many specific health concerns weight gain induced estrogen deficiency problem post menopausal women around globe present study investigates effects aqueous extract chinense post menopausal obesity female cbl mice ovariectomized fed high fat diet hfd weeks induce post menopausal obesity extract orally administrated weeks continuous hfd feeding ovarian adipose tissues uterus weighed serum triglyceride cholesterol ldl cholesterol fasting glucose levels analyzed expressions adipocyte specific factors estrogen receptors ers investigated additionally lipid accumulation confirmed differentiated adipocytes increased body weight due post menopausal obesity ameliorated treatment respectively treatment reduced serum lipid fasting blood glucose levels adipocyte hypertrophy fatty liver ameliorated treated groups treated adipocyte cells lipid accumulation significantly inhibited expression perilipin adipose tissues decreased addition expression ppar gamma protein regulated adipose tissues differentiated adipocytes glut expression increased adipose tissues treatment moreover treatment regulated expressions alpha beta accompanied increased uterine weight results showed ameliorative effects overweight menopause post menopausal obesity may improved treatment
therapeutic ultrasound beginning applied neurologic conditions potential modality wide spectrum brain applications high engineering advances allow sound waves targeted skull brain region selected real time magnetic resonance imaging thermography using commercial array focused emitters high intensities sonic energy create coagulation lesion similar older radiofrequency stereotactic methods without opening skull led recent food drug administration approval focused ultrasound fus thalamotomy unilateral treatment essential tremor clinical studies stereotactic fus aspects parkinson disease chronic pain refractory psychiatric indications underway promising results moderate intensity fus potential safely open blood brain barrier localized delivery therapeutics low levels sonic energy used form neuromodulation
model based image analysis indispensable medical image processing one key aspect building statistical shape appearance models determination one one correspondences training data set time identification correspondences challenging part methods earlier work developed alternative method using correspondence probabilities instead exact one one correspondences statistical shape model hufnagel work new approach statistical appearance models without one one correspondences proposed sparse image representation used build model combines point position appearance information time probabilistic correspondences derived multi dimensional feature vectors used omit need extensive preprocessing finding landmarks correspondences well reduce dependence generated model landmark positions model generation model fitting expressed optimizing single global criterion derived maximum posteriori map approach respect model parameters directly affect shape appearance considered objects inside images proposed approach describes statistical appearance modeling concise flexible mathematical framework besides eliminating demand costly correspondence determination method allows additional constraints topological regularity modeling process evaluation model applied segmentation landmark identification hand xray images results demonstrate feasibility model detect hand contours well positions joints finger bones unseen test images evaluated model brain data stroke patients show ability proposed model handle partially corrupted data demonstrate possible employment correspondence probabilities indicate corrupted pathological areas elsevier rights reserved
directions speeds motion rain areas estimated type rain fronts using time differences detected rain attenuation band satellite radio wave signals measured osaka electro communication university oecu neyagawa osaka research institute sustainable humanosphere rish uji kyoto observatory kyoto university shigaraki shiga past five years since september directions speeds shown agree well directly obtained motion rain fronts weather charts published japan meteorological agency rain area motion found characteristic directions according rain type cold warm fronts typhoon numerical estimate effects site diversity techniques indicates two sites among three locations oecu rish separated joint cumulative time percentages rain attenuation become lower two sites aligned along directions rain area motion case compared itu recommendations distance required two sites may average reduced conventional predictions
novel dimensionality reduction method named nonlocal local structure preserving projection nllspp proposed used process monitoring nllspp simultaneously preserve nonlocal structure data variance local structure neighborhood relationships data points data set according nonadjacent neighboring relationships different pairs data points nllspp defines nonlocal local similarity weight coefficients pairwise data points basis distances nonlocal similarity weight coefficients force two nonadjacent data points projected far apart local similarity weight coefficients force two neighboring data points projected near way nonlocal local structures data set naturally preserved highlighted lower dimensional space advantage nllspp powerful principal component analysis pca locality preserving projections lpp extracting important data characteristics process monitoring method developed based nllspp algorithm advantages illustrated case study tennessee eastman process results indicate nllspp based method better monitoring performance pca based lpp based methods elsevier rights reserved
wireless network group computer network devices using wireless communication many types jamming attacks affecting wireless communication order avoid jamming attacks flow network communication network security helps manage uninterrupted solution wireless communication using swarm intelligence provide collaborative deductive solution different jamming attacks wireless communication investigation provides security issues wireless sensor networks requirements challenges wireless sensor networks wsn wireless sensor networks provide ordered reliable observation features physical phenomena otherwise difficult scrutinize also instigation right actions based collective information wireless sensor network nodes application swarm intelligence optimization helps several network performance social applications target tracking disaster management field inspection ecological habitation monitoring healthiness application residence automation traffic management pointed
six gear bus traditional internal combustion engine modified hybrid electric vehicle hev uses engine motor power sources vehicle simulation model set avl cruise software simulation platform researching optimizing relevant technical parameters logic threshold control strategy based ruling required torque written control vehicle driving mode torque portion effects different degree hybrid doh vehicle performance studied selected engine matching different motors based results simulation models standard condition road spectrum vehicle performance cost different doh analyzed build multi objective function constraint condition paper also develops new method better performance global search local search algorithm improve quality solutions subgroup self adaptive evolutionary programming novel algorithm evolution cauchy operator gauss operator parallel performed different mutation strategies gauss operator owns ability self adaptation according variation adaptability function algorithm used seek pareto optimal solution multi objective function hev best doh model obtained validity method verified later experiment
paper proposes robust optimization algorithm enabling global optimum tracking construction uncertainty factors handling high speed permanent magnet motor design new robustness criterion introduced considering effectively impact construction tooling uncertainties design variables objective functions adaptive network based fuzzy inference system anfis developed acting surrogate time consuming finite element analyses resulting computationally acceptable electric machine design procedure
mast cells stimulated immunoglobulin ige crosslinking secrete mediators mainly categorized three groups granule contents arachidonate metabolites cytokines mediators play important roles pathogenesis allergic diseases indeed conventional drugs target mediators used clinical practices however drugs yet sufficient enough efficacy blockers single mediators unable prevent simultaneously various reactions caused three group mediators spleen tyrosine kinase syk non receptor protein tyrosine kinase mast cells syk locates almost top signal cascades induced ige crosslinking plays pivotal roles secretion three groups mediators therefore inhibition syk would suppress secretion mediators mast cells promising treatment strategy allergic diseases present study characterized pharmacological profiles jte identified novel syk inhibitor jte inhibited kinase activity syk adenosine triphosphate atp competitive fashion jte also blocked secretion granule contents arachidonate metabolites cytokines mast cells stimulated ige crosslinking similar potencies results suggest jte supposed prevent various allergic reactions caused three group mediators vivo fact oral gavage jte attenuated allergic reaction mediated histamine representative three groups mediators jte expected novel highly efficacious orally available anti allergic drug
review begins discussion nature stress presents functional model primary headache framework conceptualizing complex relationship stress headaches research reviewed stress trigger headaches stress play role developmental psychosocial context headaches clinical management headaches stress perspective considered level trials behavioral interventions broadly fit stress management category additional strategies might useful individual cases based research demonstrating associations stress headaches review concludes suggesting although researchers questioned whether stress trigger headaches overall literature still supportive link advances methodology discussed recent emphasis protective factors welcomed directions future research suggested
nosql databases designed address performance scalability requirements web based application addressed traditional relational databases due contrast priorities architecture conventional relational databases using sql databases referred nosql databases since incorporate lots additional features addition features conventional databases relational databases strongly follow acid atomicity consistency isolation durability properties nosql databases follow base basically available soft state eventual consistency principles survey paper analytical study base features nosql databases elsevier rights reserved
rogers ramanujan identities various analogous identities gordon andrews bressoud capparelli etc form family deep identities concerned integer partitions identities written generating function form typically form product side equals sum side product side enumerating partitions obeying certain congruence conditions sum side obeying certain initial conditions difference conditions along possibly restrictions use symbolic computation generate various sum sides use euler algorithm see actually produce elegant conjectured product sides rediscover many known identities also discover apparently new ones conjectures supported strong mathematical evidence
background high sensitivity cardiac troponin assays enable myocardial infarction ruled earlier optimal approach uncertain compared european society cardiology rule pathway pathway incorporates lower cardiac troponin concentrations risk stratify patients methods patients suspected acute coronary syndrome underwent high sensitivity cardiac troponin measurement presentation hours compared european society cardiology pathway centile presentation hours symptoms hours pathway developed high steacs study high sensitivity troponin evaluation patients acute coronary syndrome population presentation change centile hours primary outcome comparison negative predictive value pathways index type myocardial infarction type myocardial infarction cardiac death days evaluated primary outcome prespecified subgroups stratified age sex time symptom onset known ischemic heart disease results primary outcome occurred patients less centile presentation european society cardiology pathway ruled myocardial infarction presentation hours respectively missing index two day events negative predictive value confidence interval high steacs pathway ruled presentation hours missing index two day events negative predictive value confidence interval comparison negative predictive value high steacs pathway greater european society cardiology pathway overall subgroups including presenting early known ischemic heart disease conclusions use high steacs pathway incorporating low high sensitivity cardiac troponin concentrations rules myocardial infarction patients presentation misses fold fewer index myocardial infarctions guideline approved pathways based exclusively centile
china faces challenge balance future urbanization process resource conservation environmental protection promoting sustainable construction identified chinese government important strategy tackle challenges promote sustainable construction chinese government released large number laws policies regulations paper investigates policy system china aims facilitate transition sustainable construction related laws policies regulations analyzed three main functions identified namely regulation control economic incentives supporting activities results show behaviours various participants construction industry including government developers builders suppliers designers regulated controlled laws regulations subsidy policies award policies economic innovation policies adopted government promote renewable energy applications buildings infrastructure construction key supporting activities sustainable construction include strengthening technology innovation improving standards evaluation establishing demonstration projects publicity two emerging challenges current policy system also identified lack considering social economic dimensions sustainable construction ineffectiveness key policies environmental impact assessment policy paper provides useful reference construction corporations policy makers china facilitate sustainable construction future urbanization process similarly policy makers emerging economies understand sustainable construction promoted china elsevier ltd rights reserved
schizotypal personality disorder spd characterised thought disorders experiences illusions obsessive ruminations bizarre eccentric behaviour cognitive problems deficits social functioning symptoms spd shares schizophrenia efforts undertaken investigate relationship conditions regarding genetics pathophysiology phenomenology however treatment spd antipsychotics received less scientific attention embase pubmed databases searched using known generic names antipsychotics search terms combination following diagnostic terms latent schizophrenia schizotypal disorder latent type schizophrenia spd studies categorised according evidence level basis methodology best worst five hundred nine studies retrieved scrutinised sixteen studies period antipsychotic treatment spd extracted four studies categorised evidence level two level six level three level one study level four randomised double blind placebo controlled trials subjects well defined diagnoses exists amisulpride risperidone thiothixene studied according evidence level result warrants high quality studies effects antipsychotic treatment spd
background mood disorders especially bipolar disorder frequently associated substance use disorders suds well designed trials treatment suds absence comorbid condition however one generalize study results individuals comorbid mood disorders therapeutic efficacy safety tolerability profiles may differ presence comorbid disorder therefore review available evidence needed provide guidance clinicians facing challenges treating patients comorbid mood disorders suds methods reviewed literature published january november using following search strategies pubmed search terms bipolar disorder depressive disorder major exclude depression postpartum dysthymic disorder cyclothymic disorder seasonal affective disorder cross referenced alcohol drug substance abuse dependence disorder possible level evidence determined treatment using framework previous canadian network mood anxiety treatments recommendations lack evidence based literature limited authors ability generate treatment recommendations strictly evidence based recommendations often based authors opinion results even though large number treatments investigated alcohol use disorder aud none sufficiently studied justify attribution level evidence comorbid aud major depressive disorder mdd available data allows generate first choice recommendations aud comorbid mdd third choice recommendations cocaine heroin opiate sud comorbid mod recommendations possible cannabis amphet amines methamphetamines polysubstance sud comorbid mdd first choice recommendations possible alcohol cannabis cocaine sud comorbid second choice recommendations heroin amphetamine methamphetamine polysubstance sud comorbid recommendations possible opiate sud comorbid finally psychotherapies certainly considered essential component overall treatment suds comorbid mood disorders however well designed studies needed order properly assess potential role specific suds comorbid mood disorder conclusions although certain treatments show promise management mood disorders comorbid suds additional well designed studies needed properly assess potential role specific suds comorbid mood disorder
utilizing remote sensing techniques extract soil properties facilitate several engineering applications large scale monitoring modeling purposes earthen levees monitoring landslide mapping road mobility modeling study presents results statistical analyses investigate potential correlations multiple polarization radar backscatter various physical soil properties study conducted approximately long section earthen levees along lower mississippi river part development remote levee monitoring methods polarimetric synthetic aperture radar imagery uavsar used along extensive set situ soil properties following properties analyzed top soil texture sand clay fraction penetration resistance sleeve friction cone tip resistance saturated hydraulic conductivity field capacity permanent wilting point porosity results showed correlation cross polarized radar backscatter coefficients properties soil properties like clay fraction showed similar weaker correlations polarized channels correlations soil properties radar backscatter analyzed separately river side land side levee found magnitude direction correlation soil properties noticeably differed river land sides findings study good starting point scattering modelers pursuit better models radar scattering cross polarizations would include diverse set soil parameters elsevier rights reserved
specific defensive behaviors rodents shaped features eliciting threat stimuli situation threat scenarios confirmed relationships people results substantially replicated additional scenario studies subsequent human studies involve computer games measuring fear flight threat stimuli anxiety alternation two threats stabilometric studies shown reduction sway freezing inescapable gun pointed subject threatening photographs enhanced lateral sway flight attempts escapable threats gun pointed away subject relationships threat ambiguity risk assessment anxiety validated identification videos facial expressions ambiguous threats anxiety systematic biases toward threat stimuli anxious individuals enhanced rumination interpretable unsuccessful risk assessment dynamic component anxiety depression particularly women less experimental work defensive threat attack transdiagnostic fear harm phenotype aggression associated fear suggests component pathological well normal human defensive behavior published elsevier ltd
paper shows methodology design construction aircraft type quadcopter describe aerodynamic effects often presented vehicles mechanical considerations construction instrumentation required operation also shown criteria considered implementation pid controller results obtained application stabilize quadrotor vertical similarly shows flight time obtained selected instrumentation vehicle
developed lymphoproliferative disorder screening tube lpd aim provide comprehensive immunophenotyping lymphocyte subsets minimal need additional testing lpd consists kappa fitc lambda cdecd cdpc cdpc cdapc cdapc cdapc cdpb cdko lpd validated previously used lymphocyte subset panels canada sweden oneflow lst lpd panel implemented clinical practice using dried monoclonal antibody reagents duraclone patient samples sweden samples monotypic cell population found cases final diagnosis could rendered cases remainder additional cell immunophenotyping performed samples aberrant cell population confirmed additional testing samples diagnosed normal reactive lymphoid tissue required additional immunophenotyping mostly due abnormal ratio lpd tube significantly minimizes need additional testing improves turn around time reduces cost lpd immunophenotyping also suitable investigating paucicellular samples cerebrospinal fluid fine needle aspirates
year old somali woman presented features right sided cavernous sinus syndrome confirmed neuroimaging although initial investigations equivocal infectious etiology subsequent investigations led diagnosis tuberculosis cause right sided cavernous sinus syndrome case illustrates although incidence tuberculosis cavernous sinus syndrome reportedly low patients originating tuberculosis endemic regions warrant scrupulous investigations order miss diagnosis effect appropriate treatment elsevier inc rights reserved
total sixteen tacrine curcumin hybrid compounds designed synthesized purpose searching multifunctional anti alzheimer agents vitro studies showed hybrid compounds showed good cholinesterase inhibitory activity particularly potency even beyond tacrine compounds exhibited different selectivity acetylcholinesterase butyrylcholinesterase due structural difference thus structure activity relationship summarized discussed based molecular modeling studies orac mtt assays indicated hybrid compounds possessed pronounced antioxidant activity could effectively protect cells beta induced toxicity moreover hybrid compounds also showed positive metal ions chelating ability vitro suggesting potential halt ion induced aggregation obtained results demonstrated tacrine curcumin hybrid compounds particular compound considered potential therapeutic agents alzheimer disease elsevier ltd rights reserved
paper mathematical models supercapacitors investigated models based electrical circuits form ladder networks elementary cell network may consist resistances capacitances connected series parallel dynamic behavior circuit described using fractional order differential equations properties analyzed identification procedure quadratic performance index performed time domain identify parameters supercapacitor models results numerical simulations compared results measured experimentally physical system addition example automotive industry used experimental evaluation theoretical analysis present perspective applicability approach industrial projects
present study microalga rhizoclonium hookeri effectively applied remove metal ions aqueous solution batch adsorption mode experiments adsorption process influenced several operating parameters initial metal ion concentration contact time particle size adsorbent dose temperature maximum monolayer adsorption capacity found ions respectively optimum conditions calculated thermodynamic parameters illustrated adsorption process found spontaneous endothermic nature experimental data analyzed terms pseudo first order pseudo second order elovich kinetic models results showed removal ions followed pseudo second order kinetics adsorption isotherm data described using two three parameter models results indicate adsorption data best fitted sips isotherm model consequently microalga good adsorbability reusability could used effective adsorbent adsorption ions wastewater
older adults years older racial ethnic populations projected increase comparison whites non hispanics meet demand training ethnically diverse health staff long term care facilities palliative hospice care imperative purpose study evaluate palliative hospice care training staff two nursing homes hawaii evaluate knowledge confidence three time periods compare staff family caregiver satisfaction end program educational frameworks based cultural communication theories fifty two ethnically diverse staff majority asian participated week module training one hour communication skills workshop staff evaluation included knowledge confidence surveys pre post test knowledge tests famcare satisfaction instrument nine asian pacific islander family caregivers completed famcare satisfaction instrument overall staff knowledge confidence results promising staff rated overall satisfaction palliative care services lower family caregivers implications future research practice education palliative hospice care training ethnically diverse nursing home staff include patient family caregiver satisfaction palliative hospice care services evaluation effectiveness cross cultural communication theories palliative hospice care staff training support administration mentorship development services long term care facilities
backgroundthis study addresses children parents intellectual disability norway aim examine impact definitions intellectual disability prevalence whether numbers increasing iii prevalence motherhood fatherhood rates lost custody methodsanalyses national registers mapping four municipalities results children parents recorded intellectual disability increasing wider inclusion criteria number children born parents intellectual disability declining since mid proportion mothers intellectual disability twice fathers parental custody revoked children single mothers particular risk parents intellectual disability accounted custody cases conclusionsthe results show prevalence depends definition intellectual disability decreasing number children need development specially adapted family supports discussed
using senior health professionals interviewers cluster sampling survey carried investigate community perceptions pilia local word jaundice east delhi india persons mostly mothers children aged years interviewed aware pilia illness people knew correct symptoms dangers causes prevention pilia correct responses related faeco orally transmitted viral hepatitis literate respondents significantly aware pilia chi symptoms chi causes chi dangers chi prevention chi however age respondents significant bearing greater equal correctness responses subjects considered pilia treatable illness respectively expressed preference modern indigenous systems medicine treatment contrast respondents said would prefer faith healers treatment pilia although persons aware vaccine pilia hepatitis vaccine virtually agreed children immunized vaccine made available study underscores usefulness pilia lay reporting viral hepatitis epidemiological studies jaundice associated illnesses need educating community causes prevention increase people participation controlling viral hepatitis diseases mainly manifest jaundice
roofers long suffered low back disorders lbds primary nonfatal injury construction ergonomic studies identified several risk factors associated lbds workplaces developed biomechanical models general lbd risk assessments however models directly used assessments roof workplaces designed general tasks without considering roofers posture variance effects working slanted roof surfaces paper examined relationship roofing work related factors lbd risk among roofers using laboratory assessment pitch configurable wood platform built mimic rooftop maximum trunk flexion angle normalized electromyography emg signals measured indicators using motion capture system skeletal muscle signal recording system different settings different roof slopes postures facing directions working paces results indicated measured factors significant effects lbd development revealed unfavorable conditions using stooped posture work low pitch rooftops fast pace work rooftops needs particular attention information useful systematic understanding roofing nonfatal lbd developments among construction professionals may enable development interventions guidelines reducing prevalence lbds roofing jobsites american society civil engineers
previous studies emphasized antisocial personality disorder apd psychopathy overlap highly differ critically several features notably negative emotionality nem possibly amygdala reactivity social signals threat distress examined whether dimensions psychopathy apd correlate differentially nem amygdala reactivity emotional faces testing relationships among healthy individuals dimensions psychopathy apd generated profile matching technique lynam widiger using facet scales neo personality inventory revised amygdala reactivity measured using well established emotional faces task community sample men women higher psychopathy scores associated lower nem lower amygdala reactivity whereas higher apd scores related greater nem greater amygdala reactivity overlapping variance apd psychopathy adjusted statistical model amygdala reactivity mediate relationship apd psychopathy scores nem supplemental analyses also compared measures factors within psychopathy predicting nem amygdala reactivity found factor psychopathy positively related nem amygdala reactivity across measures psychopathy overall findings replicate seminal observations nem psychopathy hicks patrick extend work neuroimaging normative population also suggest one critical way apd psychopathy dimensions may differ etiology opposing levels nem amygdala reactivity threat
ihep institute high energy physics beijing china started high field accelerator magnet technology recently proposed cepc sppc circular electron positron collider super proton proton collider project conceptual design study dipole magnet ongoing common coil configuration model magnet fabricated next two years step process proposed realize common coil model magnet first subscale magnet fabricated nbsn nbti superconductors investigate fabrication process characteristics nbsn coils subscale magnet fabricated nbsn superconductors test stress management method quench protection method nbsn coils final step fabricating common coil dipole magnet hts ybco nbsn superconductors test field optimization method hts nbsn coils characteristics steps introduced paper
background asthma management may involve step treatment symptoms well controlled examined whether budesonide formoterol maintenance reliever therapy mrt effective higher fixed dose budesonide plus needed terbutaline patients requiring step step treatment low dose inhaled corticosteroids stratified baseline reliever use methods post hoc analysis utilized data three clinical trials months duration patients aged years symptomatic asthma uncontrolled despite step treatment included severe exacerbation rate lung function reliever use analysed stratified baseline reliever use occasions day results overall patients included reductions severe exacerbation rate budesonide formoterol mrt versus fixed dose budesonide similar across baseline reliever use levels statistically significant patients using reliever occasions day reliever occasions day occasions day respectively conclusions treatment benefit budesonide formoterol mrt versus higher fixed dose budesonide plus short acting agonist found step patients relatively low reliever use supporting proposal budesonide formoterol mrt may useful asthma uncontrolled low dose inhaled corticosteroid
phase detectors play essential role cdr circuits recover clock data paper operational trans resistance amplifier otra based phase detector circuit proposed proposed circuit simple realize consists two otra based comparators cmos xor circuit integrator spice simulations proposed circuit using cmos process parameters given verify theoretical analysis
recently performance dual fuel strategy multi cylinder engines whole engine map received increasing attention research focuses potential homogeneous charge induced ignition hcii combustion fueled gasoline diesel meeting euro emission standard whole operating range using simple treatment system combustion mode utilizes port injection high volatile fuel gasoline form homogeneous charge direct injection high ignitable fuel diesel near top dead center tdc trigger combustion paper experimental numerical investigation combustion characteristics emission formation hcii multi cylinder heavy duty engine conducted effects gasoline ratio one important parameters dual fuel mode explored analyzed detail recommended better combustion emission performance operating condition paper hcii also turns effective strategy reduce nox soot emissions time furthermore high thc emissions hcii combustion eliminated using diesel oxidation catalyst doc hcii strategy optimized whole operating range showing great potential meeting euro limitations doc treatment device fuel consumption also reduced dual fuel strategy elsevier ltd rights reserved
excessive exposure solar suv related numerous human skin disorders skin inflammation photoaging carcinogenesis lak cell originated protein kinase topk upstream mitogen activated protein kinase jun terminal kinases jnks plays important role suv induced skin inflammation targeting topk already strategy prevent skin inflammation study found expression topk phosphorylation jnks increased human solar dermatitis tissues level phosphorylation jnks increased dose time dependent manner hacat cells cells suv treatment paeonol active component isolated traditional chinese herbal medicines mts dimethylthiazol carboxymethoxyphenyl tetrazdium assay showed toxicity cells microscale thermophoresis mst assay showed paeonol bind topk vivo vitro kinase assay showed paeonol inhibit topk activity vivo studies showed paeonol suppressed suv induced phosphorylation level jnks msk histone hax inhibiting topk activity time dose dependent manner paeonol inhibited secretion tnf alpha hacat cells vivo vivo studies demonstrated paeonol inhibited suv induced increase topk phosphorylation jnks hax secretion tnf alpha babl mouse summary data indicated protective role paeonol suv induced inflammation targeting topk paeonol could promising agent treatment suv induced skin inflammation
despite providing water related services primary purpose urban water system uws relevant activities require capital investments operational expenditures consume resources materials chemicals may increase negative environmental impacts contaminant discharge emissions water air performance assessment metabolic system may require developing holistic approach encompasses various system elements criteria paper analyses impact integration uws components metabolism based performance assessment future planning using number intervention strategies also explores importance sustainability based criteria assessment long term planning two assessment approaches analysed planning water supply system wss part uws planning integrated uws including potable water stormwater wastewater water recycling watermet model used simulate metabolic type processes uws calculate quantitative performance indicators analysis demonstrated problem strategic level planning real world uws optional intervention strategies applied resulting performance assessed using multiple criteria conventional sustainability type optional intervention strategies ranked using compromise programming method results obtained show high ranked intervention strategies integrated uws supporting water supply stormwater wastewater subsystems rainwater harvesting greywater recycling schemes whilst strategies ranked low wss targeting improvement water supply components rehabilitation clean water pipes addition new water resources preferred instead results also demonstrate conventional sustainability type performance indicators necessary strategic planning uws elsevier rights reserved
study design prospective magnetic resonance imaging mri study objective investigate change aortic traversing length patients thoracolumbar kyphosis secondary ankylosing spondylitis closing wedge osteotomy cwo summary background data cwo widely adopted correction thoracolumbar kyphosis caused procedure aorta may elongated instrumented area implies potential risk aortic injury date reports specifically published using mri investigate alteration aortic traversing length patients undergoing cwo methods june july patients thoracolumbar kyphosis mean age years recruited present study patients underwent single level cwo mri examinations performed weeks surgery subject aortic diameter length measured mri radiographic measurements included global kyphosis thoracic kyphosis lumbar lordosis local kyhosis angle fusion levels anterior height osteotomized vertebra height patients also recorded results aortic traversing length significantly increased average surgery significant changes height global kyphosis lumbar lordosis local kyphosis angle fusion levels observed addition correlation analysis revealed significant correlation aortic traversing length changes global kyphosis lumbar lordosis local kyphosis angle fusion levels height conclusion stretch aorta cwo correction thoracolumbar kyphosis quantitatively verified mri investigation present study spine surgeons aware potential vulnerability aortic injury patients undergoing cwo
women engage prenatal physical activity give child advantage women engage prenatal physical activity significant health benefits mothers also great benefits unborn child breastfeeding another important decision parents make affect mother child extensive research benefits prenatal physical activity breastfeeding connection two unclear purpose grounded theory article identify potential connections factors influencing women decisions engage prenatal physical activity breastfeeding among mothers medium sized city tennessee responses mothers revealed numerous themes related prenatal physical activity breastfeeding connections prenatal physical activity breastfeeding addition overarching theme captured women collective experience identified
cnc based hybrid manufacturing systems capable additive manufacturing machining developed metal large thermoplastic components currently cad cam systems seamlessly integrate additive machining tool paths simulation required complete hybrid manufacturing solution tool paths bead based generated simply reversing processing order waterline machining tool paths process planning modules significantly different machining unique process planning challenges related geometry establishing relevant process specific settings thermodynamics tool path planning realistic virtual process simulation discussed support hybrid manufacturing output additive manufacturing simulation must employed stock model subsequent machining paper discusses architecture process data flows bead based processes results presented primarily laser cladding
hidradenitis suppurativa debilitating inflammatory skin disease chronic course often disappointing response treatment though minority persons reports symptom remission pregnancy vast majority experiences relief experience clinical deterioration disease flares also observed post partum pathophysiological basis pregnancy associated fluctuations clinical status currently unknown women require ongoing management throughout pregnancy important evaluate suitability safety current treatment options pregnant women following review outline current management strategies compatibility pregnancy lactation
effects single oral dose liothyronine thyroid stimulating hormone tsh related thyroid system parameters partly understood despite therapeutic use hormone many decades characterize individualized responses hypothalamus pituitary thyroid hpt axis related temporal hormonal profile using electrical network model based thyroid hormone responses blood samples using single oral dose liothyronine healthy persons normal operating euthyroid feedback hpt system derived equivalent electrical circuit model system responses mathematical model tested circuit simulator validated individualized clinical data signal processing technique makes evaluation bioequivalence bioavailability various preparations liothyronine individualized level feasible endeavor clinical application
study ultra low voltage low power operational transconductance amplifier ota proposed dynamic threshold voltage mos dtmos transistors utilized design using low supply voltages efficiently proposed ota circuit employed fourth order band pass filter topology used eeg data processing help spice matlab programs found simulations close agreement theoretical calculations
objective investigate usefulness diffusion weighted imaging dwi comparing clinical features blood parameters traditional short tau inversion recovery stir sequence detecting spinal sacroiliac joint inflammation axial spondyloarthritis axspa patients methods one hundred ten axspa patients recruited clinical radiological blood parameters recorded dwi stir mri performed simultaneously results scored according spondyloarthritis research consortium canada sparcc comparison apparent diffusion coefficient adc values also calculated results dwi correlate clinical parameters blood parameters also lowered sensitivity compared stir sequence correlated well stir sequence joint level weakly spinal level joint level presence inflammation stir sequence dwi associated increase maximum stir dwi mean adc values stir dwi maximum mean spinal adc values also positively associated dwi detected spinal inflammation presence modic lesions showed positive correlation stir sequence spinal adc values conclusion despite dwi correlates stir sequence lower sensitivity however adc values appear independent modic lesions may supplement stir sequence differentiate degeneration
century age information emanated great abilities information flows information technology manufacturing systems modern manufacturing seeking engineering knowledge model virtual means research presents model integrated consideration industrial logistics cost inside manufacturing company simultaneously applies manufacturing engineering new product logistics issues searching minimal cost delivery time managers engineers often neglect industrial logistics possibilities inside company emphasizing endeavors processes facilities tooling potential machinery however often limited companies innovate often machine tools human factor seldom used properly developed model considers links among machine tools operation manufacturing time transport means time lead time products inventory production lines store developed model considers available production alternatives estimating logistics costs integrated manner product process parameters order tasks research helps create target manufacturing cost order wining concluding section paper discusses model implementation peculiarities shows findings consistent patterns
assess occupational health group vulnerable workers southeast asians lowell massachusetts researchers surveyed residents cambodian lao ethnicity regarding working conditions health problems use medical services reported work electronics computer assembly fourth currently employed held temporary jobs workplace hazards included soldering fumes inadequate ventilation prolonged sitting standing awkward postures unguarded machinery shift work long hours pressure produce quickly common work related health problems included sprains strains headache dizziness flu like symptoms less third respondents knew workers compensation household surveys provide otherwise unavailable occupational health data defined populations
objectivesto survey experts headache medicine opinions regarding appropriate non inferiority margins outcomes commonly used migraine research methodsmembers american headache society canadian headache society invited participate non inferiority margins migraine research nimm survey adult child neurologists expertise headache medicine eligible participate survey multiple choice format comprised questions respondent characteristics eligibility well expert opinion non inferiority margins outcomes commonly used trials prophylactic acute interventions migraine resultsninety nine eligible respondents completed survey respondents adult neurologists reported practicing usa following commonly selected non inferiority margins change monthly migraine attacks comparing baseline treatment period attack selecting change monthly migraine days comparing baseline treatment period day change average migraine intensity point scale comparing baseline treatment period percentage participants pain free hours intervention percentage participants migraine recurrence within hours treatment percentage participants sustained pain freedom conclusionsthe results nimm survey describe opinions group experts appropriate non inferiority margins outcomes commonly used migraine clinical trials significant variability responses lack consensus choice non inferiority margins survey incorporate patient perspective validated prior distribution work area required order explore incorporate clinical considerations selection non inferiority margins migraine research
typically developing children frequently refer objects uniquely gesture parents translate gestures words facilitating children acquisition words goldin meadow dev sci ask whether pattern holds children autism syndrome show delayed vocabulary development observed children children parents year children used gestures indicate objects labeling parents translated gestures words importantly children benefited input acquiring words translated gestures translated ones results highlight role contingent parental input child gesture plays language development children developmental disorders
preclinical alzheimer disease characterized amyloid deposition absence overt clinical impairment substantial heterogeneity long term clinical outcomes among amyloid positive individuals yet limited work focused identifying molecular factors driving resilience amyloid related cognitive impairment apply recently developed predicted gene expression analysis predixcan identify genes modify association baseline amyloid deposition longitudinal cognitive changes participants free clinical selected neuroimaging initiative adni baseline positron emission tomography measure amyloid deposition quantified standard uptake value ratio longitudinal neuropsychological data genetic data predixcan used impute gene expression levels across heart brain tissues mixed effect regression models assessed interaction predicted gene expression levels amyloid deposition longitudinal cognitive outcomes predicted gene expression levels two genes coronary artery cntln prok two genes atrial appendage prss prok interacted amyloid deposition episodic memory performance predicted gene expression levels two additional genes tmc basal ganglia hmbs aorta interacted amyloid deposition executive function performance post hoc analyses provide additional validation hmbs prok effects across two independent subsets adni using two additional metrics amyloid deposition results highlight subset unique candidate genes resilience provide evidence cell cycle regulation angiogenesis heme biosynthesis likely play role progression
endometriosis hormone dependent inflammatory disease usually characterized infertility pain symptoms disease mainly occurs reproductive years rarely diagnosed menopause discuss physiopathology condition menopause well treatment options risk malignant transformation occurrence progression postmenopausal endometriosis lesions could related extra ovarian production estrogen endometriosis lesions adipose tissue becomes major estrogen producing tissue menopause postmenopausal women symptomatic endometriosis managed surgically risk malignancy medical treatments used cases pain recurrence surgery aromatase inhibitors act decreasing extra ovarian estrogen production blocking feed forward stimulation loop inflammation aromatase within endometriosis lesions evidence currently insufficient support conclusion optimal hormone replacement therapy women endometriosis question malignant transformation endometriosis response hormone replacement therapy women history endometriosis remains unanswered needs long term follow study evaluate risk adverse outcome studies performed determine optimal management menopausal women endometriosis
background fatigue anesthesiologists may implications extend beyond individual well aim aim present study evaluate impact sleep deprivation reaction time anesthesiologists either overnight call regular working hours moderation effect coping strategies observed methods psychomotor vigilance test used assess reaction time anesthesiologists two time points regular non call day house call student paired test used compare psychomotor vigilance task data two moments change score regression performed determine association coping strategies assessed using coping strategy indicator instrument decline reaction time night call results twenty one colleagues completed psychomotor vigilance test measurements two decided end participation personal reasons post call psychomotor vigilance test mean reaction time decreased average compared regular day reliance specific coping mechanisms indicated coping strategy indicator scale scores included problem solving followed seeking social support avoidance change score regression model found greater reliance avoidance associated greater increase reaction time night call conclusion reaction time increased considerably anesthesiologists night call duty greater subjective reliance avoidance coping strategy associated greater deterioration performance
mirror neuron system mns mooted crucial component underlying human social cognition initial evidence based functional magnetic resonance imaging fmri suggests mns plays role emotion classification confirmation convergent evidence needed study employed electroencephalography eeg examine modulations rhythm associated inference emotions facial expressions hypothesised suppression would associated classifying emotion portrayed facial expressions nineteen participants viewed pictures facial expressions emotion words asked either match stimulus emotion word passively observe activity following stimulus presentation localised using distributed inverse solution compared conditions subtractive logic used isolate specific processes interest comparisons source localisation images conditions revealed suppression associated recognising emotion faces thereby supporting hypothesis analyses confirmed effects due activity associated motor response observation facial expressions offering support hypotheses study provides important convergent evidence involvement mns inference emotion facial expressions
introduction establishment prognostic models crohn disease highly desirable potential guide physicians decision making process concerning therapeutic choices thus improving patients health quality life aim derive models disabling reoperation based solely clinical demographic data methods multicentric retrospectively enrolled cohort patients subject early surgery immunosuppression analysed order build bayesian network models risk matrices final results validated internally multicentric prospectively enrolled cohort results derivation cohort included total patients disabling disease needed reoperation validation cohort included patients similar outcome proportions bayesian models achieved area curve disabling disease reoperation age diagnosis perianal disease disease aggressiveness early therapeutic decisions found significant factors used construct user friendly matrices depicting probability outcome patients various combinations factors matrices exhibit good performance important criteria disabling disease positive post test odds reoperation negative post test odds conclusions clinical demographical risk factors disabling reoperation determined impact quantified means risk matrices applicable bedside clinical tools help physicians therapeutic decisions early disease management
students solve problems developing mental models problem although models many diverse common one used engineering mechanics education consists identifying known unknown variables construction graphical problem representation developing mathematical model derived preceding steps also case courses physics mechanics science electrical circuits model computer based implementation approach problem solving utilizes visual graphic variables identification listing mathematical equation mental models construct students developing stem problem solving skills paper describes students use model solve problems coaching tools paper discusses design objectives intelligent tutor features model applied engineering mechanics course also discusses model may used encourage students develop mental model approaches problem solving assessment model also presented
reduced graphene oxide rgo modified layered wse nanosheets synthesized facile one pot solvothermal reaction compared bare wse nanosheets relatively poor photocatalytic activity wse rgo composite demonstrates significant enhancement photocatalytic degradation organic dye rhb visible light irradiation value wse rgo similar times larger bare wse nanosheets attributed excellent charge separation feature electronic transport ability graphene nanosheets leading highly reduced electron hole pair recombination graphene wse nanosheets thus strongly enhancing photocatalytic performance wse rgo composite promising catalyst photocatalytic degradation organic pollutants solar energy elsevier rights reserved
background adolescents prone sleep problems unique developmental aspects contribute physical emotional behavioural problems aims study evaluated individualized multicomponent intervention considered developmental factors promoted age appropriate autonomy three adolescent females disrupted sleep method adolescents recorded sleep data daily logs nonconcurrent multiple baseline design used evaluate cognitive behavioural intervention including sleep hygiene training bedtime routine development cognitive restructuring relaxation training stimulus control sleep restriction bedtime fading problem solving along clinically indicated individualization results outcomes demonstrated clinically meaningful improvements decreased variability sleep parameters following intervention participant sleep log data indicated improvement maintenance adequate total sleep time tst decreased sleep onset latency sol improved sleep efficiency improvement time sleep onset decreased continued low frequency night awakenings anecdotally adolescents parents reported improvement daytime functioning coping sense wellbeing conclusions cases highlight potential cognitive behavioural interventions facilitate healthy sleep adolescents challenging sleep problems
carrying bilingual teaching professional courses graduate students inevitable trend education development reform also important measure make domestic higher education connect international education basis clarifying concept bilingual teaching necessity feasibility develop bilingual teaching course advanced manufacturing engineering analyzed detail based bilingual teaching practice several years several instruction methods proposed furthermore issues teacher student interactive teaching proportions using english bilingual teaching application multi media courseware bilingual teaching discussed researched comprehensively view making students master professional knowledge improve english skill
silver complexes alkyl sulfonic acide hydrazides newly synthesized homologous series methanesulfonic acide hydrazide ethanesulfonic acide hydrazide propanesulfonic acide hydrazide butanesulfonic acide hydrazide used complexation ions silver complexes obtained mol ratio structural formula iii complexes exhibit distorted linear two fold coordination agl cations uncoordinated nitrates ligands chelated silver ions unsubstituted primary nitrogen hydrazide group complexes characterized using elemental analysis spectroscopic methods magnetic susceptibility conductivity measurements silver complexes optimized using pbepbe lanldz defsv basic set performed dft method gaussian program package geometrical parameters frontier molecular orbitals homos lumos molecular electrostatic potential mep mapped surfaces optimized geometries also determined quantum set anticancer activities silver complexes mcf human breast cancer cell line investigated comparing values antibacterial activities complexes studied gram positive bacteria aureus atcc subtilis atcc cereus nrrl faecalis atcc gram negative bacteria coli atcc aeruginosa atcc pneumonia atcc using disc diffusion method inhibition activities complexes carbonic anhydrase enzyme hca also investigated comparing values biological activity screening shows complex butanesulfonicacidehydrazide highest activity tested breast cancer cell lines mcf gram positive gram negative bacteria carbonic anhydrase hca isoenzyme elsevier rights reserved
terrestrial laser scanners frequently used measurement application particularly documentation restoration studies indoor historical structures acquiring facade reliefs compared photogrammetric method terrestrial laser scanners ability give three dimensional point cloud data directly fast detailed way high data density point cloud data challenging factor texture map operations documentation restoration historical artifacts indoor spaces coordinate information terrestrial laser scanner point cloud data documented seen regular order classification data aim study suggest mathematical filtering algorithm segmentation work towards separation planar surfaces different depths parallel frequently encountered indoor spaces data terrestrial laser scanner filtering function segmentation used based distance point plane algorithm chosen advantage rapid easy results extracting coordinate data texture mapping process matlab interface developed using method analyzing results application detected many different surfaces exist according statistical deviation amount application test data points segmented separating points total four different planes four corner points per plane surfaces four different depths obtained result research included four points segmented surfaces consisting four points facilitate integrated data production integrating vectorial terrestrial laser scanner data raster camera data without need conventional measurements accelerate particularly documentation modeling fields historical indoor areas elsevier ltd rights reserved
accurate evaluation soil dynamic properties essential seismic response analyses sites number studies site properties identified using one dimensional analyses analyses uncouple two dimensional horizontal response soil deposits inherently coupled paper presents system identification technique takes account coupled two directional response soil deposits technique employs non parametric estimates shear stresses derived acceleration records provided vertical downhole array multi yield surface plasticity approach used model multi dimensional stress strain relation identification technique first verified using finite elements computational simulations technique used assess coupled response wildlife liquefaction research site imperial valley california identified shear moduli shear wave velocities found good agreement measured field using crosshole seismic testing
paper presents dynamic viscoelastic properties magnetorheological grease variation magnetic fields magnetic particle fractions tests discern field dependent properties undertaken using rotational oscillatory shear rheometers first step grease developed dispersing carbonyl iron particles grease medium mechanical stirrer experimental data obtained changing magnetic field room temperature degrees found strong payne effect limits linear viscoelastic region grease strains results exhibit high dynamic yield stress equivalent bingham plastic rheological model show relatively good effect high shear rate addition high dispersion magnetic particles good thermal properties proven results presented work directly indicate grease smart material candidate could widely applicable various fields including vibration control
using large survey czech high school students aged years paper explores youth prejudice wide range minority groups family school community contexts taken account general structural equation models used explore determinants prejudice minorities using comparative explanatory framework focus gender differences prejudice minorities examined using three social theories social dominance theory sdt theory gendered prejudice tgp gender role beliefs grb research shows gender plays strong role expressing prejudiced attitudes females express less prejudiced attitudes toward roma black africans gays mental physical disabilities prejudiced attitudes towards homeless vietnamese muslims lesbians gendered pattern explained terms insights sdt tgp grb
background aims several studies demonstrated sleep problems associated functional gastrointestinal disorders fgids irritable bowel syndrome ibs functional dyspepsia etc relationship excessive daytime sleepiness eds fgids systematically studied general population study aims explore relationship eds specific types fgids effect number fgids eds methods sample individuals aged years selected regions china using randomized stratified multi stage sampling method eds measured epworth sleepiness scale gastroesophageal reflux disease gerd fgids assessed reflux disease questionnaire rome diagnostic criteria respectively results survey completed individuals response rate individuals eds eds significantly associated ulcer like dyspepsia diarrhea predominant ibs alternating ibs functional constipation gerd risk eds increased along increasing numbers fgids fgid fgids fgids conclusions fgids ulcer like dyspepsia diarrhea predominant ibs alternating ibs functional constipation gerd significantly associated eds suffered kinds fgids susceptible eds
background defects tmem gene cause type congenital disorder glycosylation affecting golgi glycosylation processes tmem patients exhibit psychomotor retardation important osteoporosis scoliosis irregular epiphyses thin bone cortex tmem protein highly conserved evolution belongs family upf membrane proteins could unique group antiporters regulating homeostasis mainly localized golgi apparatus methods pcr human brain tissues revealed tmem splice transcript variants mrna expression analyzed pcr expression plasmids allowed visualize isoform proteins subcellular localization functions glycosylation achieved looking gel mobility highly glycosylated proteins cells overexpressing isoforms results study highlight previously shown ion channels existence tmem splice transcripts isoforms particular short form long form transcripts leading protein isoform respectively proteins localize endoplasmic reticulum different effects glycosylation compared wild type protein also point expressed low levels human cells tissues checked excepted brain forms homodimer expressed temporal lobe human brain general significance finding numerous splice variants could lead family tmem isoforms family tmem splice transcripts could participate fine regulation tmem isoforms functions localizations elsevier rights reserved
background clozapine antipsychotic used treatment resistant schizophrenia adverse gastrointestinal effects significant associated morbidity mortality however effects defined patterns colonic contractile activity assessed method used novel radial longitudinal spatiotemporal mapping techniques combined monitoring ambient lumen pressure vivo preparations triply singly haustrated portions rabbit colon identified contractile patterns mass peristalses fast phasic ripple contractions directly qualified effects clozapine concentrations mol mol mol norclozapine main metabolite clozapine contractile patterns effects carbachol serotonin naloxone clozapine exposed preparations also determined tetradotoxin used distinguish neurogenic myogenic contractions results mol clozapine temporarily abolished longitudinal contractile components mass peristalsis return significantly reduced number amplitude maximal mass peristaltic pressure effects reversed carbachol mol extent serotonin mol mol myogenic ripple contractions affected mol clozapine similar marked effect mass peristalses longitudinal radial components corresponding maximal pressure greatly reduced mol clozapine suppressed radial longitudinal components mass peristalses min well ripple contractions similar dose related effects observed addition clozapine mid colon mol norclozapine opposite effects clozapine causing increase frequency mass peristalsis slight increases basal tone slightly augmented contractions abolished addition clozapine concentrations norclozapine mol discernible effects conclusion clozapine norclozapine potent effects motility rabbit colon inhibiting neurogenic contractions lower concentrations myogenic contractions higher concentrations likely mechanism serious life threatening gastrointestinal complications seen human clozapine users effects appear mediated cholinergic serotonergic mechanisms spatiotemporal mapping useful directly assessing effects pharmaceuticals particular patterns gastrointestinal motility
supply electrical power requires generator must driven prime mover form mechanical drivetrain electro mechanical system natural resonant modes electrical mechanical subsystems subsystems interfaced electrical generator useful transfer power may also couple unwanted disturbances electrical mechanical domains resulting interaction interaction lead lifetime reduction mechanical components instability electrical network resulting poor reliability wider system predicting occurrence interaction simulation challenging requiring multi domain models operating different time scales paper analyses aircraft auxiliary power offtake produce reduced order mechanical drivetrain model allowing modal frequencies predicted cross domain interactions modelled purpose built electro mechanical test platform used validate model demonstrate electrical disturbances passed generator mechanical system future research use test bed demonstrate strategies avoiding suppressing unwanted interactions
nonlinear least squares regression valuable tool gaining chemical insights complex systems yet success nonlinear regression measured residual sum squares rss correlation reproducibility fit parameters strongly depends availability good initial solution without iterative algorithms quickly become trapped unfavorable local rss minimum determining initial solution high dimensional parameter space needs screened process time consuming parallelized another advantage parallelization equally important determining initial solutions used processors tasked optimize initial guess even several optimizations become stuck shallow local rss minimum processors continue improve regression outcome software package parallel processing based constrained nonlinear regression regressionlab developed implemented tested variety hardware configurations proof principle microalgae environment interactions studied infrared attenuated total reflection spectroscopy additionally light microscopy used monitor cell production shown spectroscopic data sets data points nonlinear model parameters well imaging data data points nonlinear model parameters may investigated constrained nonlinear regression acceleration factors obtained high practical relevance computations take weeks single processor machines solely using parallel processing rss values may improved factor
alternative splicing pattern transcription units influenced genotype neighboring locus termed splicing quantitative trait locus sqtl report comprehensive catalog sqtls discovered public rna seq matched genotype datasets three european ancestries pair rna seq genotype dataset analyzed ivas locally developed bioconductor package sqtl discovery meta analysis applied three result sets reach consensus sqtls fdr among nine independent sqtls overlapped known signals catalog genome wide association studies interestingly six sqtls associated alternative exons whose absence would hamper protein function omitting critical conserved domain altogether report list candidate sqtls might useful explanations trait associated polymorphisms
paper implementation training modules presented teaching support area power semiconductor devices practical learning discipline system composed five modules allow development different applications power electronics including power electric control prototypes developed aim student validate test typical circuits employed topic easy intuitive form
despite formally included dsm disorder internet addiction become worldwide issue broadly defined non chemical behavioral addiction involves human machine interaction pinpoint instrumental form social interaction mediated machines notion appears useful sake possible preclinical modeling features internet use reveals addictive comes expense genuine real life sociability overlap towards hikikomori phenomenon extreme retreat one room due specific neuro developmental plasticity adolescence poses risks youths mental health may likely produce negative consequences everyday life thwarted development adolescents identity self image adaptive social relationships discussed adolescents often suffer loss control feelings anger symptoms distress social withdrawal familial conflicts severe clinical conditions also associated dysthymic bipolar affective social anxiety disorders well major depression paper overviews literature neuro biological psychosocial clinical standpoints taking account recent debates diagnostic criteria nosographic label assessment tools neuroimaging data neurochemical regulations illustrated links pathogenetic hypotheses amenable validation innovative preclinical modeling elsevier ltd rights reserved
proportional integral derivative pid controller tuning area interest researdhers many areas science engineering paper presents new algorithm pid controller tuning based combination bacteria foraging particle swarm optimization bfo algorithm recently emerged powerful technique real parameter optimization overcome delay optimization combine features bfoa pso tuning pid controller new algorithm proposed combine algorithms get better optimization values real time prototype model paper machine designed controlled using pic microcontroller embedded programming language
background investigated prevalence post procedural headache patients undergone thrombectomy ischemic stroke correlated history migraine risk peri procedural complications total patients underwent thrombectomy danish national hospital january december eligible subjects phone interviewed using purpose developed semi structured questionnaire according international classification headache disorders beta version criteria findings among eligible subjects significant decrease migraine within first months evt compared year treatment evident interview time average years evt minority patients experienced headaches first time within months evt migraine tth persisted interview time subjects migraine subjects peri procedural complications history migraine aura conclusion thrombectomy leads significant decrease previously known migraine new onset headache small subset patients history migraine appear predispose peri procedural complications
aviation military police health care personnel particularly interested operational impact sleep restriction work schedules given potential severe consequences making fatigue related errors studies examining impact sleep loss circadian manipulations conducted controlled laboratory settings using small sample sizes study examined whether relationship prior night sleep duration performance psychomotor vigilance task could reliably detected field study healthy police academy recruits subjects medically psychiatrically healthy sleep wake activity assessed wrist actigraphy days subjects performed psychomotor vigilance task pvt min personal digital assistant pda device police academy workday comparable times days mixed effects logistic regression used estimate probability lapse pvt function previous night sleep duration days field testing valid estimates sleep duration obtained nights sleep probability lapse decreased sleep night prior testing overall probability lapse decreased since awakening holding hours sleep constant perceived stress associated sleep duration probability performance lapse findings demonstrate feasibility detecting sleep circadian effects cognitive performance large field studies findings implications regarding daytime functioning police officers author correspondence thomas neylan ucsf edu
article aims extend third person effect research cross cultural context third person perception perceptual gaps media effect self others dissimilar association willingness support regulation media content united states south korea investigated survey results demonstrate larger third person perception among respondents among korean respondents regression mediation analyses reveal different levels third person perception mainly result direct influence nationality cultural values statistically significant accounting third person perception contrast koreans show greater level support censorship violent video games americans national difference behavioral intention direct effect nationality intention support regulation indirect effect cultural values collectivism addition gender age religiosity negative prejudice violent video games collectivism presumption media effects others contributed support preemptive behavioral measures censorship however frequent playing violent video games decreases support regulation addition implications research third person perception intention support media content regulation discussed
background pregnancy related risk factors cataract understudied including possibility preeclampsia increases risk cataract later life objective sought evaluate long term risk cataract extraction following preeclamptic pregnancy study design carried historic cohort study women delivered least infant hospital province quebec canada including preeclampsia cataract extractions categorized preeclampsia onset time severity followed women years delivery calculated incidence inpatient cataract extraction women without preeclampsia used cox proportional hazard models estimate hazard ratios confidence intervals later risk cataract extraction adjusting age first delivery total parity metabolic disease asthma socioeconomic deprivation time period results women preeclampsia higher incidence cataract extraction compared preeclampsia times risk confidence interval women early onset preeclampsia times risk cataract extraction compared preeclampsia confidence interval whereas women late onset preeclampsia times risk confidence interval risk elevated severe mild preeclampsia preeclampsia diabetes associated significantly greater risk hazard ratio confidence interval conclusion women preeclampsia particularly preeclampsia early onset diabetes may greater risk cataract later life underlying pathways linking preeclampsia cataract require investigation
gain boosted operational amplifier designed using positive feedback technique presented paper design differential output differential amplifier merged single output differential amplifier used positive feedback applied appropriately proposed amp designed cmos process using gpdknm library cadence virtuoso analog design environment simulation proposed circuit results gain mhz ugb degree phase margin power consumption monte carlo analysis circuit indicates variation power supply voltage produces minimal effect gain phase circuit
objectives despite recent advances perioperative management postoperative atrial fibrillation flutter poaf remains common complication cardiac surgery therefore important determine related risk factors establish effective management however studies focused patients undergoing coronary artery bypass grafting little known poaf receive aortic valve replacement avr investigated relationship clinical predictors poaf patients undergoing avr methods total patients underwent avr enrolled study relationships poaf incidence perioperative preoperative operative postoperative factors examined results poaf occurred patients univariate analysis older age significantly associated poaf occurrence significantly related prolonged intensive care unit icu stay postoperative stroke also showed patients preoperative beta blocker experienced poaf less frequently without beta blocker multivariate analysis showed preoperative beta blocker usage independent predictor poaf patients received preoperative oral postoperative intravenous beta blocker administrations incidence poaf reduced conclusions poaf frequently occurred patients undergoing avr significantly related prolonged icu stay postoperative stroke findings show advanced age absence preoperative beta blocker usage risk factors poaf furthermore patients undergoing avr perioperative intravenous beta blocker administration may useful prevention
manufacturing industry currently faces big challenges global competition dealing increasing costs energy raw materials one hand increasing quality requirements high product technology innovation expectations customer hand next decade overall progress technology demand new strategies increase international acceptance positive management increasing competition global market paper proposal establish strategic approach advanced intelligent networked measurement technique automated measurement evaluation processes well highest accuracy smallest uncertainty measurement processes research higher education time manufacturing industry using example application development modeling construction implementation experiments inter university network demonstrated thereby cooperation implementation working steps two remote research laboratories namely nanotechnology laboratory aum vienna university technology austria control engineering laboratory utn frba argentina described
aid symbolic computation maple new integrable generalization classical wadati konno ichikawa hierarchy derived corresponding matrix spectral problem associated lie algebra equation resulting hierarchy hamiltonian structure furnished trace identity possesses infinitely many independent commuting symmetries conservation laws elsevier rights reserved
despite extensive literature parental monitoring studies focused father youth solicitation particular none solicitation via communication technology address gap study explored relationships fathers online person solicitation adolescent emerging adult children youth internalizing externalizing prosocial behaviors sample fathers reported solicitation patterns use technology child behaviors results revealed differences demographics inverse trend online person solicitation relation internalizing externalizing prosocial behaviors regression analyses revealed online solicitation information youth friends related greater internalizing externalizing less prosocial behavior findings support research suggesting forms online solicitation may interpreted adolescents emerging adults intrusive violation privacy
central eastern europe huge wastewater treatment wwt developments carried last years include building upgrading wastewater treatment plants wwtps especially extending lifetimes nutrient removal digester gas production hungary example households connected wwt number increased increase currently medium sized wwtps capacity around population equivalent facing development needs especially technical energy efficiency aspects paper presents results comprehensive investigation program included wwtps capacities ranging investigations included evaluation important parameters inflowing wastewater characteristics mechanical biological wwt effluent wastewater quality removal efficiency investigated reference electrical energy consumption extension wwtps anaerobic sludge digestion led possibility producing electricity digester gas prospect currently great interest medium sized wwtps also investigated results also compared international data standards guidelines obtained research basis development strategy main bottleneck areas design operation considered upgrading requirements explored american society civil engineers
paper introduces high frequency soft switching pulse width modulation power converter secondary active rectifier tested current source arc welding applications soft switching converter consists high frequency full bridge inverter high frequency power transformer controlled output rectifier new secondary energy recovery turn snubber circulating currents converter reduced using active rectifier rms values currents primary secondary switches decreased utilizing novel control algorithm experimental results converter working switching frequency khz presented
testes biased genes evolve rapidly important establishment solidification maintenance reproductive isolation incipient species anopheles gambiae complex group least eight isomorphic mosquito species endemic sub saharan africa excellent system explore evolution testes biased genes within group testes important tissue diversification process hybridization species results sterile hybrid males fully fertile females conducted rna sequencing gambiae merus carcass testes explore tissue species specific patterns gene expression data provides support transcriptional repression linked genes male germline likely drives demasculinization chromosome testes biased genes predominately function cellular differentiation show number interesting patterns indicative rapid evolution including elevated values low evolutionary conservation poor annotation existing reference genomes high likelihood differential expression species
article fractional derivatives sense modified riemann liouville exp function method used construct exact solutions nonlinear partial fractional differential equations via nonlinear fractional liouville equation nonlinear fractional zoomeron equation nonlinear fractional equations turned another nonlinear ordinary differential equation complex transform method method efficient powerful solving wide classes nonlinear fractional order equations exp function method appears easier convenient means symbolic computation system
global signal widely used regressor normalization factor removing effects global variations analysis functional magnetic resonance imaging fmri studies however considerable controversy use potential bias introduced applied analysis task related resting state fmri studies paper take closer look global signal examining detail various sources contribute signal part global signal treated nuisance term growing evidence may also contain valuable information also examine various ways global signal used analysis fmri data including global signal regression global signal subtraction global signal normalization furthermore describe new ways understanding effects global signal regression relation approaches
patients masticatory muscle pain migraine typically report intensity pain fluctuates time affected weather changes weather variables ambient temperature humidity may vary significantly depending whether individual outdoor indoor therefore important assess variables individual level using portable monitors everyday life study aimed determine compare temporal patterns pain individuals affected facial head pain investigate relation weather changes eleven patients years chronic masticatory muscle pain twenty years migraine headache asked report current pain level visual analogue scale vas every hour fourteen consecutive days vas scores collected using portable data loggers also used record temperature atmospheric pressure relative humidity vas scores varied markedly time groups pain vas scores fluctuate less group group mean minimum maximum values higher migraine patients pain scores common group perceived intensity pain negatively associated atmospheric pressure group positively associated temperature atmospheric group results reveal patients masticatory muscle pain patients migraine present typical temporal pain patterns influenced different way weather changes
apolipoprotein allele present worldwide despite associations higher risk cardiovascular morbidity accelerated cognitive decline aging alzheimer disease allele especially prevalent tropical regions high parasite burden equatorial populations also face potential dual burden high prevalence combined parasitic infections also reduce cognitive performance examined interactions parasite burden cognitive performance traditional nonindustrialized population amazonian forager horticulturalists test whether protects cognitive decline environments heavy pathogen burden contrary observations industrial populations older adult carriers high parasite burdens either maintained showed slight improvements cognitive performance whereas non carriers high parasite burden showed reduced cognitive performance carrier strongest risk factor date cognitive decline industrial populations associated greater cognitive performance individuals facing high parasite pathogen load suggesting advantages allele certain environmental conditions current mismatch postindustrial hygienic lifestyles active parasite rich environs may critical understanding genetic risk cognitive aging trumble stieglitz blackwell allayee beheim finch gurven kaplan apolipoprotein associated improved cognitive function amazonian forager horticulturalists high parasite burden faseb www fasebj org
recovery waste heat electrical generator water preheating circuit steam thermal power plants stpp method frequently used increase electricity production without additional consumption primary energy however manufacturers turbine generator sets explicitly indicate effect method performances using numerical modeling steam cycle paper presents method effects stpp performances also shows method simple fast enough accurate estimating effects could applied possible recalculate whole cycle
dealing renovation restoration historical building heritage often means facing several difficulties concern ways representing ancient building design ideas also phases site interventions designers must always take account range possible compatible solutions avoid endangering cultural significance historical building traditional methods often time consuming barely efficient related exchange two dimensional paper based support information building information modelling bim may represent answer problems allowing users model three dimensional compounds building link variety information aim article propose innovative approach construction management historical building interventions based bim technologies explore different issues parametric modelling historical buildings starting laser scanner survey lod level detail definition measurement accuracy relation modelling procedures parametric modelling site several phases restoration work fixed schedule dimension graphic representation safety procedures related tools subject case study nome maria church italy built seriously damaged earthquake occurred italy elsevier rights reserved
dementia encapsulates set symptoms include loss mental abilities memory problem solving language reduces person ability perform daily activities alzheimer disease common form dementia however dementia also occur neurological disorders huntington disease many studies demonstrated loss neuronal cell function manifests pre symptomatically thus relevant therapeutic target alleviate symptoms synaptopathy physiological dysfunction synapses approached target many neurological psychiatric disorders including autosomal dominant progressive degenerative disorder clinical manifestations encompass movement cognition mood behaviour one common tandem repeat disorders caused trinucleotide cag repeat expansion encoding extended polyglutamine tract huntingtin protein animal models well human studies provided detailed although exhaustive evidence synaptic dysfunction review discuss neuropathology changes synaptic signalling diseased brain lead symptoms include dementia review discuss mechanisms molecular orchestras synaptic symphonies disrupted neurodegeneration dementia focusing model disease also explore therapeutic strategies currently pre clinical clinical testing targeted towards improving synaptic function elsevier ltd rights reserved
paper study real time implementation position control based electric elevator drive information contained within paper serves framework expand usefulness electric drives addition digital control systems switching power supplies tangible example elevator driven permanent magnet motor position control used relate work apply various mechanical systems tasks accomplished achieve electric elevator drive position control follows determining parameters motor designing control system direct motor desired verifying performance system use computer simulations real time hardware loop hil experimental testing
introduction chronic myeloproliferative disorders cmpd chronic myeloid hematological disorders characterized increased myeloid cell proliferation fibrosis impaired apoptotic mechanisms increased cell proliferation uncontrolled hematopoietic cell proliferation myeloaccumulation may contribute pathogenesis cmpd aim study show possible role fas fasl gene polymorphisms cmpd pathogenesis investigate association clinical parameters susceptibility disease material methods included polycythemia vera primary myelofibrosis pmf essential thrombocythemia cmpd patients diagnosed according classification criteria healthy controls study patients controls investigated fas fasl gene expression allele frequencies phenotype features also fas mrna levels analyzed results chronic myeloproliferative disorders patients showed increased fas genotype distribution compared control group gene polymorphism clinical parameters splenomegaly thrombosis statistically significant difference fasl genotype allele frequency found groups moreover statistically significant difference detected fasl jakvf mutations fas mrna expression fold reduced patients compared healthy subjects conclusions according findings fas fasl gene expression may contribute molecular immunological pathogenesis cmpd investigations needed support data
paper show algorithmic procedure compute abelian subalgebras ideals given finite dimensional leibniz algebra starting non zero brackets law order implement method symbolic computation package maple used moreover also show brief computational study considering computing time memory used two main routines implementation finally determine maximal dimension abelian subalgebras ideals dimensional leibniz algebras dimensional solvable ones
epidemiological genetic studies identified metabolic disorders inflammation risk factors alzheimer disease evidence obesity type diabetes suggests role metabolic inflammasome metaflammasome mediating chronic inflammation peripheral organs implicating ikk inhibitor nuclear factor kappa kinase subunit beta irs insulin receptor substrate jnk jun terminal kinase pkr double stranded rna protein kinase hypothesized proteins expressed brain response metabolic risk factors neocortex participants mrc cognitive function ageing studies analysed immunohistochemistry expression phosphorylated active form ikk pser irs jnk pthr tyr pkr data analyzed investigate whether proteins expressed together relation metabolic disorders dementia alzheimer pathology apoe genotype observed change positive negative association proteins hypertension according dementia status type diabetes negatively related proteins among participants without dementia whereas participants dementia pathology showed positive association jnk significant association ikk jnk participants dementia pathology observed without dementia otherwise weak moderate associations observed among protein loads presence dementia significantly associated jnk negatively associated ikk irs cognitive scores showed significant positive relationship ikk negative irs jnk pkr proteins significantly associated pathology alzheimer participants relationship inverse significant participants without dementia expression proteins related apoe genotype findings highlight role proteins pathophysiology necessarily complex
objective considerable evidence patients schizophrenia neurocognitive social cognitive deficits unclear deficits first episode schizophrenia relate current clinical symptoms method fifty nine patients first episode schizophrenia fes tested using danish version nart premorbid subtests wais iii current global cognition using brief assessment cognition schizophrena bacs neurocognitive test battery social perception tested using film clips everyday interactions tasit theory mind tom tested using silent animations animated triangles task fes subjects experiencing psychotic symptoms several years mean duration years confidence interval fes patients divided clinical subgroups based level positive negative symptoms using sans saps healthy controls matched patients results high levels negative symptoms associated low estimated functional poor neurocognition social cognition sans subscales avolition apathy significant negative impact social cognition effects positive symptoms complex high levels delusions associated higher premorbid presence high levels negative symptoms high levels positive symptoms associated comprehensive deficits social perception absence negative symptoms high levels positive symptoms associated deficits conclusion results suggest social cognitive training need take account mentioned effects symptoms
although hazardous harmful alcohol use impacts response hiv treatment attempts deliver alcohol reduction interventions within south african hiv treatment services first step towards implementing alcohol focused interventions settings explored patients views acceptability brief motivational interviewing problem solving intervention depth interviews conducted patients recruited three hiv treatment sites tshwane south africa completed intervention participants noted intervention acceptable appropriate result intervention participants reported less use alcohol coping mechanism described greater use problem focused emotional coping strategies dealing mutable immutable problems respectively recommendation improving intervention addition booster sessions findings suggest intervention acceptable patients receiving hiv treatment perceived helpful reducing use alcohol
protection critical infrastructures complex virus attacks automated network traffic analysis deep packet inspection unavoidable however even use network intrusion detection systems number alerts still large analyze manually addition discovery domain specific multi stage viruses advanced persistent threats typically captured single alert result security experts overloaded low level technical alerts must look presence apt paper propose alert oriented visual analytics approach exploration network traffic content multiple contexts approach conta contextual analysis network traffic alerts experts supported discover threats large alert collections interactive exploration using selections attributes interest tight integration machine learning visualization enables experts quickly drill alert collection report false alerts back intrusion detection system finally show effectiveness approach applying real world artificial data sets
well functioning hematopoietic system requires certain robustness flexibility maintain appropriate quantities functional mature blood cells red blood cells platelets review focuses cytokine receptor plays significant role thrombopoiesis receptor thrombopoietin tpo also known mpl survey work date understand receptor functions molecular level throughout lifecycle traffic cell surface dimerization binding cognate cytokine via extracellular domain subsequent activation associated janus kinases initiation downstream signaling pathways well regulation processes atomic level resolution structures tpo remained elusive identification disease causing mutations receptor however offered insight structure function relationships artificial means receptor activation tpo mimetics transmembrane targeting receptor agonists engineering dimerization domains recently novel activation mechanism identified whereby mutated forms calreticulin form complexes tpo via extracellular glycosylated domain complexes traffic pathologically cell persistently activate jak downstream signal transducers activators transcription stats pathways pathologic tpo activation associated large fraction human myeloproliferative neoplasms
computational evolution design provides mechanism searching potential solution space according specified fitness function evolutionary design approach design problem solving requirements solutions design evolve separately affect paper devoted new computational evolutionary product design approach undirected graph parameters mechanism proposed model relationships among design parameters shortest path searching vertex undirected graph parameters mechanism also put forward help undirected graph parameters mechanism evolutionary product design process discussed detail iterative interleaved mapping function mechanism concept structure concept detailed structure evolutional design key components cold heading machine given example demonstrates methodology helpful product design
despite great efforts recent years accelerate global illumination computation real time ray tracing fully dynamic scenes support photorealistic indirect illumination effects yet achieved computer graphics paper propose extended ray tracing model readily implemented gpu facilitate interactive generation diffuse indirect illumination quality comparable generated traditional time consuming photon mapping method final gathering method employs three types multilevel grids represent indirect light scene using form facilitates efficient estimation reflected radiance caused diffuse interreflection method includes mathematical tool spherical harmonics rendering scheme performs final gathering step minimal cost ray tracing guarantees interactive frame rates evaluated technique using several dynamic scenes nontrivial complexity demonstrated effectiveness
detailed ige binding epitope analysis key requirement understanding development diagnostic therapeutic agents address food allergies ige specific linear peptide microarray random phage peptide display high resolution mapping ige binding epitopes major soybean allergen gly homologue birch pollen allergen bet combined three epitopes identified mapped resolution four key amino acids allowing rational design production three gly mutants aim abolish reduce binding epitope specific ige elisa binding mutant allergens polyclonal rabbit anti gly serum well ige purified gly reactive soybean allergy patient sera reduced compared wild type allergen basophil stimulation experiments using rbl cells loaded patient ige showed decreased stimulation wild type gly one mutant presented approach demonstrates feasibility precise mapping allergy related ige binding epitopes allowing rational design less allergenic mutants potential therapeutic agents
accurately predict buffeting induced stresses long span cable stayed bridge twin box deck buffeting analyses take account cross sectional distribution aerodynamic aeroelastic forces surface bridge deck also performed accurate multi scale model rather spine beam model bridge paper proposes framework stress level buffeting analysis long span cable stayed bridge twin box deck distributed wind loads methods obtain distributed aerodynamic aeroelastic forces bridge deck introduced proposed framework synthesizes buffeting analysis distributed wind loads multi scale modelling model updating long span bridges proposed framework applied stonecutters cable stayed bridge hong kong responses computed using proposed buffeting analysis framework compared computed using sectional force based traditional method spine beam model comparative results show significant differences stress distribution twin box deck multi scale model yields larger maximum stress responses compared spine beam model elsevier ltd rights reserved
background chronic heart failure chf chronic obstructive pulmonary disease copd frequently coexist concurrent copd chf little investigated design multicentre survey suspirium designed evaluate prevalence copd stable chf chf stable copd diagnostic therapeutic work concurrent copd chf clinical profile patients copd chf predictors copd chf chf copd methods month long cross sectional prospective observational survey conducted cardiac respiratory connected outpatient units results prevalence chf surveyed copd patients confidence interval prevalence copd chf patients confidence interval diagnostic tests suspected comorbidity prescribed copd chf patients respectively patients coexisting chf copd higher incidence hypertension physical inactivity frequently gold score greater compared chf chf copd patients significantly older frequently smokers worse respiratory risk higher new york heart association class conversely hypercholesterolaemia family history ischaemic heart disease fluid retention comorbidities frequent copd chf copd patients multivariate analysis gold score greater chf strongly predicted coexistent copd odds ratio history respiratory diseases history ischaemic heart disease atrial fibrillation sedentary lifestyle predicted coexistent chf copd conclusion high prevalence copd chf calls integrated disease management cardiologists pulmonologists suspirium identifies cardiac pulmonary outpatients screened respective comorbidity
year old spayed female american pit bull terrier dog presented primary complaint chronic refractory ascites dog cbc displayed moderate severe macrocytic hypochromic nonregenerative anemia moderate leukopenia result moderate neutropenia monocytopenia microscopic examination blood smear showed marked anisocytosis mild polychromasia mild acanthocytosis ovalocytosis moderate schistocytosis poikilocytosis metarubricytes wbc abdominal ultrasonography revealed homogenous mild moderately hyperechoic appearing liver well marked amounts speckled anechoic slightly hypoechoic peritoneal fluid cytology ascitic fluid demonstrated sterile transudate evidence chronic inflammatory reaction well erythroid myeloid precursor cells megakaryocytes occasional micromegakaryocytes histologic sections bone marrow spleen liver examined using routine stains well variety immunohistochemistry special stains histopathology bone marrow spleen revealed varying degrees fibrosis erythroid myeloid hyperplasia well multiple small hyperplastic clusters megakaryocytes megakaryocytes displayed many features atypia increased cytoplasmic basophilia occasional abnormal chromatin clumping mitoses histopathologic examination liver disclosed evidence mild extramedullary hematopoiesis case represents first report canine idiopathic myelofibrosis associated peritoneal extramedullary hematopoiesis resulting refractory ascites although idiopathic myelofibrosis relatively rare condition dogs case demonstrates ascites caused peritoneal implants hematopoietic tissue may initial manifestation myelofibrosis
major depressive disorder characterized emotional dysfunction mood states daily life well understood study examined complex explanatory models daily stress coping mechanisms trigger maintain daily negative affect lower positive affect depression sixty three depressed patients completed perfectionism measures completed daily questionnaires stress appraisals coping affect consecutive days multilevel structural equation modeling msem demonstrated across many stressors typical individual depression perceives criticism usual uses avoidant coping experiences higher event stress usual connected daily increases negative affect well decreases positive affect parallel results showed perceived control less avoidant coping problem focused coping commonly operate together daily positive affect increases msem also showed avoidant coping tendencies ongoing stress combination explain people depression higher self critical perfectionism maintain daily negative affect lower positive affect findings advance richer detailed understanding specific stress coping patterns target order effectively accomplish two predominant therapy goals decreasing patients distress strengthening resilience
paper presents accurate design approach two stage cmos operational amplifiers developed based usual design procedure eliminates errors existed design results employing accurate mos model carrying design procedure iteratively specifications amplifier designed approach match exactly user specified values design example cmos technology given illustrate effectiveness proposed design approach
study association weather related mood factors stock index returns order driven market shanghai stock exchange sse china results indicate asset returns unaffected changes mood introduced factors including weather onset recovery sad contrast many variables strongly correlated reduction market turnover liquidity consistent investor mood driving variations market activity overall show order driven market environmental impacts sentiment likely affect trading activities returns elsevier rights reserved
last years focus computer science education cse primary secondary schools shortly reached significant turning point study reviews published papers field computing education order summarize findings guide future studies give reflections major achievements area cse schools peer reviewed articles collected systematic literature search analyzed based categorization main elements programming tools educational context instructional methods main examined categories research results survey show direction cse schools research last years summarized benefits well challenges particular analyzed selected papers perspective various instructional methods aiming introducing enhancing learning using several programming tools educational context cse despite challenges findings suggest implementing computing lessons education could enjoyable effective learning experience addition suggest ways facilitate deep learning deal various implications formal informal education encouraging students create projects solve problems significant part learning process
paper presents highly resolved large eddy simulations les internal combustion engine ice using immersed boundary method ibm describe moving stationary boundaries simple efficient manner novel approach motion valves piston modeled lagrangian particles whilst stationary parts engine described computationally efficient ibm proposed mesh free technique boundary representation simple parallelization suitable high performance computing hpc demonstrate method les results presented flow combustion internal combustion engine favre filtered navier stokes equations solved compressible flow employing finite volume method cartesian grids non reflecting boundary conditions applied intake exhaust ports combustion described using flame surface density fsd model algebraic reaction rate closure simplified engine fixed axisymmetric valve see appendix employed show correctness method avoiding uncertainties may induced complex engine geometry three test cases using real engine geometry investigated different grids evaluate impact cell size filter width simulation results compared experimental data good overall agreement found measurements simulation data presented method particular advantages efficient generation grid high resolution low numerical dissipation throughout domain excellent suitability massively parallel simulations
nowadays many works presented regarding modeling simulation circuit realization different kinds continuous time multi scroll chaotic attractors however works describe experimental realization attractors high maximum lyapunov exponent mle high entropy desirable characteristics guarantee better chaotic unpredictability instance two chaotic oscillators mle values behave different way showing different entropy values way describe experimental realization optimized multi scroll chaotic oscillator high mle entropy first mle optimized applying evolutionary algorithm provides set feasible solutions second associated entropy evaluated feasible solution chapter experimental results shown electronic implementation chaotic oscillator generating scrolls finally experimental results show increasing number scrolls mle associated
growth hormone replacement therapy benefits patients hypopituitarism safety profile regard tumor recurrence progression development secondary malignancies cerebrovascular stroke still area debate comprehensive search multiple databases medline embase cochrane central register controlled trials cochrane database systematic reviews scopus conducted august eligible studies evaluated long term adverse events adult patients hypopituitarism treated growth hormone replacement therapy reported development pituitary tumor recurrence progression secondary malignancies cerebrovascular stroke selected following predefined protocol reviewers independently duplicate extracted data assessed risk bias random effects meta analysis used pool relative risks confidence intervals included studies published reported patients compared non replacement growth hormone replacement therapy adults hypopituitarism associated statistically significant change pituitary tumor progression recurrence relative risk confidence interval development secondary malignancy relative risk confidence interval two retrospective studies higher risk stroke patients receive replacement relative risk confidence interval quality evidence low due study limitations imprecision systematic review meta analysis supports overall safety growth hormone therapeutic use adults hypopituitarism clear evidence increased risk pituitary tumor recurrence malignancy stroke
echo cancellation great potential radar cross section reduction stealth technology techniques developed last decade rely primarily assumption cancellation echo target echo synchronize time domain however cancellation echo may lag behind target echo countering synthetic aperture radar sar cancellation echo generation requires extra processing time sar transmits receives large time bandwidth product signal linear frequency modulation pulses thus cancellation echo target echo cancel perfectly paper develop novel three stage active cancellation method using frequency delay time modulation cancel target echo scenario cancellation echo intentionally lag behind target echo theoretical analyses simulation results verify effectiveness proposed method
advancements information communication sensor technologies led new opportunities medical care education patients general prefer visiting nearest clinic attempt avoid waiting treatment unequal preferences different clinics doctors therefore enable patients compare multiple clinics study proposes ubiquitous multicriteria clinic recommendation system system patients send requests cell phones system server obtain clinic recommendation patient sends information system system server first estimates patient speed according detection results global positioning system applies fuzzy integer nonlinear programming ordered weighted average approach assess four criteria finally recommends clinic maximal utility patient proposed methodology tested field experiment experimental results showed advantageous two existing methods elevating utilities recommendations addition advantage shown statistically significant
helper dependent autoimmune responses develop heart lung transplantation associated fibro obliterative forms chronic rejection however specific self antigens involved typically different associated autoimmune disease investigate basis responses investigated whether removal regulatory cells blockade function reveals similar autoantigen bias found cells specific collagen type col tubulin vimentin present healthy adult peripheral blood mononuclear cells cord blood fetal thymus using synthetic peptides recombinant fragments col triple helical region compared cells healthy donors cells col reactive heart lung patients although latter responded well fragments peptides hla restricted fashion cells healthy persons responded hla restricted fashion fragments peptides col tubulin vimentin preferred targets highly conserved hitherto unknown preexisting response mhc class restricted data suggest autoimmunity heart lung transplantation may result dysregulation intrinsic mechanism controlling airway vascular homeostasis
performance enhancement one important issues high performance distributed computing systems computing systems online users submit jobs anytime anywhere set dynamic resources jobs arrival processes execution times stochastic performance distributed computing system improved using effective load balancing strategy redistribute user tasks among computing resources efficient utilization paper presents multi class load balancing strategy balances different classes user tasks multiple heterogeneous computing nodes minimize per class mean response time wide range system parameters performance proposed multi class load balancing strategy compared random distribution load balancing uniform distribution load balancing strategies using simulation results show proposed strategy outperforms two studied strategies terms average task response time average computing nodes utilization
particleboards generally made three layers using softwood major raw material limitation natural wood resources concerns carbon footprint products created significant interest environmentally friendly green building materials hardwood sawmill residue disposed solid waste investigated authors main raw material producing particleboard rmit university australia physical mechanical properties final particleboard measured analysed original materials process variables density particleboard along thickness direction uniform called vertical density profile vdp dependent upon processing parameters vdp influences particleboard properties including flexural strength dimensional stability fastening capacity important influence formation vdp altering processing variables achieve optimum particleboard properties paper presents attempt develop model predict formation vdp hardwood residue particleboard compared processing parameters using theory experimental design advantages model optimising particleboard properties also discussed
paper reviews results several prior studies highlight concept metal organic framework graphite oxide mof composites developed towards application separation media small molecule gases ambient conditions studies analyzed surface engineering standpoint mof composites developed considering advantages drawbacks composite components mof provided high porosity reactive centers dense array carbon atoms increase dispersive interactions resulting materials showed significant enhancement porosity owing formation pores interface mof crystals oxygen groups identified nucleation sites formation mof crystals heteroatoms like also contributed effect could positively enhance composites structural chemical heterogeneity heterogeneity governed excellent performance composites reactive adsorbents physical adsorbents ambient conditions mof structure collapsed upon exposure toxic gases preserved adsorption indicating recyclability materials systematic studies composite properties showed factors level oxidation flake sizes graphite precursor geometry mof crystals paramount importance dictating final morphology composite properties composites make potentially suitable gas sensing energy harvesting elsevier inc rights reserved
paper highlights magnetic equivalent circuit model wound rotor synchronous machine design model includes provisions calculate performance machines arbitrary number damper windings either axis computational cost model considered several modern computing platforms use within design allows comprehensive accurate exploration design space timeline consistent commercial product development
globalized world establishing successful cooperation people different nations becoming increasingly important present results comprehensive investigation cross societal cooperation one shot prisoner dilemmas involving population representative samples six countries identify crucial facilitators obstacles cooperation interactions involving mutual knowledge players nationalities demonstrate people hold strong transnationally shared expectations stereotypes concerning cooperation level interaction partners countries expectations strongest determinants participant cooperation paradoxically however turn incorrect stereotypes even correlate negatively reality addition erroneous expectations participants cooperation behavior driven shared social preferences vary according interaction partner nationality cross societal context social preferences influenced differences wealth ingroup favoritism well effects specific country combinations spatial distance nations
many studies reverse skyline query processing done various services existing reverse skyline query processing methods based dynamic skylines reverse skyline query processing algorithms based metric spaces location based services existing methods processing reverse skyline query limitation service domains require high costs computation provide various location based services paper propose new reverse skyline query processing method efficiently processes query moving objects addition proposed method processes continuous reverse skyline query efficiently order show superiority proposed method compare previous reverse skyline query processing method various environments result proposed method achieves better performance existing method elsevier rights reserved
binge eating disorder bed currently recognized severe disorder associated relevant psychiatric physical comorbidity marked emotional distress shame specific negative emotion highlighted central eating disorders however effect shame underlying mechanisms binge eating symptomatology severity remained unclear study examines role shame depressive symptoms weight shape concerns eating concerns body image related cognitive fusion binge eating symptomatology severity participated study patients diagnosis bed established clinical intervieweating disorder examination dwho completed measures external shame body image related cognitive fusion depressive symptoms binge eating symptomatology results revealed positive associations binge eating severity depressive symptoms shame weight shape concerns eating concerns body image related cognitive fusion path analysis showed controlling effect depressive symptoms external shame direct effect binge eating severity indirect effect mediated increased eating concern higher levels body image related cognitive fusion results confirmed plausibility model explained severity binge eating symptoms proposed model suggests bed patients perceiving others see self negatively may associated entanglement body image related thoughts concerns eating may turn fuel binge eating symptoms findings important clinical implications supporting relevance addressing shame associated processes binge eating copyright john wiley sons ltd
onabotulinumtoxina btx treatment option patients neurogenic detrusor overactivity ndo idiopathic overactive bladder oab inadequately controlled intolerant oral medications currently approved dosing oab ndo commonly injected detrusor muscle via trigone sparing sites growing evidence suggests efficacy btx may maintained fewer injection sites varying injection depth differing injection locations review focuses recent literature regarding various btx injection techniques treatment ndo oab
background number significant recent research studies used techniques economic modelling demonstrate potential benefits increasing breastfeeding rates overall specifically neonatal care paper complements growing body evidence presenting economic analysis data actual intervention getting right start programme took place north aim increasing breastfeeding kangaroo skin skin care rates neonatal units methods getting right start pragmatic multifaceted programme change delivered auspices regional health innovation education cluster established engaged neonatal units two neonatal networks aim increasing kangaroo skin skin care breastfeeding rates part evaluation programme conducted economic study comparing overall costs benefits intervention results overall economic analysis demonstrated every pound invested intervention increase kangaroo skin skin care breastfeeding rates pound pound benefit generated spread across different healthcare settings timescale realisation benefits vary increases kangaroo skin skin care generated greatest cost savings potential cost savings ranging pound minimum cost assumptions pound maximum cost assumptions increases breastfeeding associated project generated pound pound majority cost savings generated associated reductions cases gastroenteritis necrotising enterocolitis conclusion one first economic evaluations actual intervention increase breastfeeding kangaroo skin skin care neonatal units complements existing economic models demonstrating real intervention clinical practice cost effective well clinically beneficial future interventions similar methodology supported considered likely generate significant cost savings compared outlay economic evaluation frequently included studies practical interventions clinical settings increase breastfeeding
protein subunit important basic unit protein study unravel structure function seed storage proteins faba bean study identified six specific protein subunits faba bean qinghai combining liquid chromatography liquid chromatography electronic spray ionization mass lcesi bio information technology results suggested diversity seed storage proteins faba bean total proteins four groel molecular chaperones plant specific proteins identified specific protein subunits faba bean based peptide sequence also analyzed composition abundance amino acids physicochemical characteristics secondary structure three dimensional structure transmembrane domain possible subcellular localization identified proteins faba bean seed finally predicted function structure three dimensional structures generated based homologous modeling protein function analyzed based annotation non redundant protein database database ncbi function analysis optimal modeling objective study identify seed storage proteins faba bean confirm structure function proteins results useful study protein nutrition achieve breeding goals optimal protein quality faba bean
one important motivation people behaving prosocially want avoid negative obtain positive emotions prosocial behavior literature however motivations avoid negative emotions guilt approach positive emotions warm glow rarely separated sometimes even aggregated single mood management construct aim study investigate whether anticipated guilt helping anticipated warm glow helping influenced similarly differently varying situational factors related personal responsibility help helping scenarios created pilot tests established helping scenario could formulated high responsibility version low responsibility version study participants read high responsibility low responsibility helping scenarios rated either anticipated guilt helping anticipated warm glow helping separate evaluation study similar participants rated anticipated guilt helping anticipated warm glow helping joint evaluation anticipated guilt clearly higher high responsibility versions anticipated warm glow unaffected studies even higher low responsibility versions study studies anticipated guilt warm glow evaluated separately evaluated jointly personal responsibility help manipulated within subjects anticipated guilt constantly higher high responsibility versions many types responsibility manipulations anticipated warm glow higher low responsibility versions results suggest anticipate guilt fulfilling responsibility anticipate warm glow primarily beyond responsibility argue future studies investigating motivations helping measure anticipated negative consequences oneself helping anticipated positive consequences oneself helping
many contemporary engineering problems model uncertainty inherent accurate system identification virtually impossible owing system complexity lack data account availability time cost situation treated assuming true model belongs uncertainty class models context intrinsically bayesian robust ibr filter one optimal relative cost function classical sense prior distribution uncertainty class bayesian sense ibr filters previously found wiener granulometric morphological filtering paper derive ibr kalman filter performs optimally relative uncertainty class state space models introducing notion bayesian innovation process bayesian orthogonality principle show problem designing ibr kalman filter reduced recursive system similar classical kalman recursive equations except effective counterparts effective kalman gain matrix deriving recursive ibr kalman equations discrete time use limiting method obtain ibr kalman bucy equations continuous time finally demonstrate utility proposed framework two real world problems sensor networks gene regulatory network inference
paper presents novel real world application energy savings smart building environment proposed system unifies heterogeneous wireless sensor networks semantic web service middleware two complementary mutually exclusive rule based approaches enforcing energy saving policies proposed reactive agent based production rules deliberative agent based defeasible logic system deployed greek university showing promising experimental results least daily savings although percentage energy savings may seem low greatest merit method ensuring energy wasted constantly enforcing policies elsevier rights reserved
background although coffee consumption tea consumption linked diabetes relation kidney function less clear underresearched objective investigated prospective associations coffee tea consumption estimated glomerular filtration rate egfr design included participants aged doetinchem cohort study examined every coffee tea consumption cups assessed round egfr assessed using chronic kidney disease epidemiology collaboration equation based plasma creatinine cystatin determined association categories coffee tea intake egfr subsequent annual changes egfr using generalized estimating equation analyses results baseline mean egfr min tea consumption associated egfr individuals drank cups coffee min higher egfr drank cups compared absence association egfr changes suggests higher egfr among coffee consumers unlikely result glomerular hyperfiltration therefore low moderate coffee consumption expected concern kidney health general population
objective investigate association sociodemographic factors characteristics rape social support development depression posttraumatic stress disorder months rape method cross sectional survey female survivors rape carried provinces south africa months rape results one hundred female survivors sexual assault interviewed half limpopo western cape kwazulu natal kzn reported high levels ptsd moderate severe depression post rape major risk factors ptsd depression unmarried survivors rape living kzn female survivors rape kzn province times likely experience symptoms depression compared provinces married cohabiting female rape survivors times less likely report symptoms depression compared unmarried female rape survivors conclusion findings add support existing literature ptsd depression common mental health consequence rape also provide evidence survivors socio demographics marital status employment status significant contributors development symptoms depression ptsd rape results research clinical practice relevance ensuring ptsd trauma treatment focuses depth understanding various aspects sociodemographic factors rape characteristics contribute survivors mental state compound stress depression symptoms time post rape victimization
objective aim study investigate depression like behaviors juvenile rats congenital postnatal hypothyroidism methods twenty seven newborn rat pups used first month old wistar albino female rats impregnated methimazole vol given dam rats first day pregnancy postnatal days generate pups congenital hypothyroidism whereas postnatal hypothyroidism group methimazole given control group dam rats fed libitum normal tap water offspring fed breast milk mothers behavioral parameters measured juvenile forced swimming test jfst procedure jfst consisted two sessions two consecutive days minute pre test day minute test day results increased immobility decreased climbing duration observed congenital postnatal hypothyroidism groups decreased swimming duration detected postnatal hypothyroidism group hypothyroidism groups lower body weight gain compared control group congenital hypothyroidism group lowest body weight conclusion results showed hypothyroidism negative effects depression like behavior well growth development congenital postnatal hypothyroidism caused increase immobility time jfst new studies required understand differing results depression like behavior congenital postnatal hypothyroidism
vitamin fat soluble vitamin steroid hormone plays central role maintaining calcium phosphorus bone homeostasis close interaction parathyroid hormone acting classical target tissues namely bone kidney intestine parathyroid glands however vitamin endocrine system regulates several genes human genome involved cell differentiation cell cycle control cell function exerts noncalcemic pleiotropic effects extraskeletal target tissues immune cardiovascular system pancreatic endocrine cells muscle adipose tissue several studies demonstrated role vitamin supplementation prevention treatment various autoimmune diseases improvement glucose metabolism muscle adipose tissue function hence review aims elucidate effects vitamin extraskeletal target tissues investigate potential therapeutic benefit vitamin supplementation among broad group pathological conditions especially regard metabolic autoimmune diseases addition focused best daily intakes serum levels vitamin required extraskeletal benefits even still controversial appear higher widely accepted skeletal effects
paper new approach proposed robust pid controller design load frequency control lfc problem multi area power system different turbines proposed approach based kharitonov theorem stability boundary locus paper first four area power system model lfc problem presented form linear uncertain system fixed lower upper bounds coefficients stability analysis carried using kharitonov theorem lastly robust controller designed control area multi area power system beauty proposed approach fixed pid controller taking care uncertainty control area efficiency efficacy proposed approach tested two examples results compared recently proposed approaches elsevier ltd rights reserved
material design important task game animation industry often requires artist great efforts create elaborate material although several successful material editing systems already exist still hard artists design material since systems usually neither intuitive sufficiently sophisticated material representation artist friendly editing interface paper propose simple material creation flow develop material design system based intuitive material representation system artist bring creativity play designing materials realistic imaginary
dopamine receptor drd diminished patients parkinson disease brain derived neurotrophic factor bdnf responsible regulating expression drd brain previous study showed hydroxysafflor yellow hsya could increase bdnf content striatum mice experiment aimed evaluate whether hsya improve motor dysfunction induced rotenone regulating bdnf trkb drd signaling pathway mice male mice intraperitoneally treated hsya thirty minutes later intragastrically administered rotenone dose pole rotarod open field tests investigated tyrosine hydroxylase substantia nigra observed immunohistochemistry dopamine content detected high performance liquid chromatography expressions bdnf phospho tropomyosin related kinase trkb tropomyosin related kinase trkb phospho phosphoinositide kinase pik phosphoinositide kinase pik phospho protein kinase akt protein kinase akt drd assayed western blotting behavioral tests showed rotenone challenged mice displayed motor dysfunction however treatment hsya improved motor dysfunction induced rotenone hsya treatment increased number containing dopaminergic neurons substantia nigra also dopamine content striatum mice moreover expressions bdnf trkb trkb drd pik pik akt akt significantly increased rotenone plus hsya group results indicated hsya improved motor dysfunction rotenone induced model pharmacological action hsya related regulating bdnf trkb drd signaling pathway least part
occurrence intersex fish male reproductive tissues show evidence feminization found freshwater systems around world indicating potential significant endocrine disruption across species ecosystem estrogens birth control medications wastewater treatment plant effluent cited likely cause research shown endocrine disruption solely predictable based hormone receptor interactions many non hormone pharmaceuticals found effluent concentrations orders magnitude higher estrogens yet little data indicating impacts medications widely prescribed anti diabetic metformin among abundant pharmaceuticals found effluent structurally dissimilar hormones however show exposing fathead minnows pimephales promelas concentration metformin found wastewater effluent causes development intersex gonads males reduced size treated male fish reduction fecundity treated pairs results demonstrate metformin acts endocrine disruptor environmentally relevant concentrations authors published elsevier ltd
last decade china implemented public private partnership ppp projects water sector compared sectors however efficient management risks projects remains problematic many studies examined risks associated ppps china experience local governments risks received little attention literature moreover stages risks significant risks interrelated researched paper examines risks experienced local government perspective manifest across five ppp stages feasibility procurement construction operation transfer interrelationship risks across ppp stages also examined data collected via questionnaire surveys interviews analyzed using quantitative qualitative analysis findings reveal critical risk local governments impacts vary across project stages risks influence risks within across five ppp stages findings provide significant insight dynamic nature risks ppp water projects important implications practitioners developing risk mitigation strategies american society civil engineers
background african american smokers experience disproportionate copd morbidity front line copd behavioral management strategy smoking cessation less prevalent among african american smokers identifying barriers predictors smoking cessation population important bridging disparity methods study predictors enrollment attendance session urban hospital smoking cessation program examined retrospective chart review conducted pulmonary clinic patients smoked referred cessation program june may demographic smoking behavior cardiopulmonary health status variables extracted second qualitative assessment beliefs barriers smoking cessation physical activity examined sub sample population results one hundred forty seven pulmonary subjects enrolled cessation program attended sessions total sample participants copd odds ratio mother cancer odds ratio likely attend program qualitatively pulmonary care patients wanted quit smoking physically active cited strong beliefs inability engage behaviors belief quitting increased activity might exacerbate poor health inability obtain pharmacotherapy barriers adopting behaviors conclusions smoking cessation program attendance sample mostly african american smokers poor increased knowledge cessation benefits access full course pharmacotherapy particularly without copd diagnosis maternal history cancer may high priority targets promote cessation program uptake population increased knowledge access safe forms physical activity may also beneficial
fonsecaea pedrosoi sensu lato major causative agent dematiaceous fungal infection japan recent sequence analysis internal transcribed spacer regions ribosomal rna gene shown species separated three species pedrosoi sensu stricto monophora nubica cell walls dematiaceous fungi including genus fonsecaea contain melanin important virulence polyketide synthase pks enzyme required melanin synthesis study analyzed phylogeny strains pedrosoi sensu lato isolated japan sequencing pks gene regions identifying molecular polymorphism sixty strains morphologically identified pedrosoi isolated worldwide including strains isolated japan analyzed regions ribosomal rna gene part pks gene region amplified yielding sequences approximately respectively polymerase chain reaction products sequenced cluster analysis performed proposed phylogenetic tree based pks sequences closely matched based regions sequencing regions showed isolates japan belonged clade monophora molecular variations japanese strains evaluated assessing pks sequences isolates could divided least seven molecular subtypes combination two molecular markers provides robust method intraspecies subtyping epidemiological study monophora
evidence based preventive interventions adolescent substance use violence mental health issues increasingly adapted disseminated internationally present paper report results effectiveness study part comprehensive initiative coalition health promotion organizations lombardy region italy select culturally adapt implement evaluate sustain evidence based drug abuse prevention program developed usa findings presented large scale effectiveness study life skills training prevention program among students attending middle schools italy prevention program taught drug refusal skills antidrug norms personal self management skills general social skills relative comparison group students students received prevention program less likely initiate smoking post test year follow less likely initiate weekly drunkenness year follow program direct positive effects several cognitive attitudinal skill variables believed play protective role adolescent substance use findings study show drug abuse prevention program originally designed adolescents usa effective sample italian youth rigorous systematic approach cultural adaptation followed incorporates input multiple stakeholders
purpose making right bid bid decision critical success development construction contracting enterprises decision makers personal characteristics risk perception propensity great impact bid bid decisions major concern research purpose paper explore relationship among decision makers risk perception risk propensity bid bid decision making construction projects well factors influencing risk perception propensity design methodology approach total four hypotheses proposed based extensive literature review experimental questionnaires distributed employees working chinese construction contracting enterprises knowledge construction bidding valid questionnaires obtained multivariate statistical analysis spss used analyze acquired data findings data analysis shows context international construction contracting risk perception negative influence bid bid decision making risk propensity produces positive influence probability magnitude potential gain loss significant impacts risk perception probability plays important role originality value research studied bid bid decision making construction projects new perspectives risk perception risk propensity decision makers
objective assess sexual behaviors contraceptive use sample brown university students study design total undergraduate students responded anonymous online survey may survey addressed level sexual activity behaviors contraceptive use female responders compared results surveys conducted results surveyed undergraduates sexually active sexual activity among women similar previous survey years contraceptive pills common primary contraceptive method reported students used dual method contraceptive use sexually transmitted disease std pregnancy prevention observed plateau condom use among women increase use long acting reversible contraception larc uncommon conclusion educational efforts emphasize effectiveness larc dual method contraceptive use reduce risk stds unintended pregnancies
background perceptions appropriateness treatments may differ gastroenterologists gis inflammatory bowel disease ibd patients aim study explore compare gis patients perceptions risks benefits treatments prioritization expected outcomes methods four vignette cases drawn clinical situations used three independent focus groups gis ulcerative colitis crohn disease patients content analysis performed based conversation transcripts results agreed often gis treatment choices often considered asa placebo saw topical asa temporary solution neither comfortable practical professionally active azathioprine considered treatment risks versus benefits perceived highest main risk perceived patients anti tnfs potential loss response divergences observed stop treatment easily concur stopping treatment differed gis expectation patients perceptions prone consider stopping treatment gis perception outcomes physicians focus long term objective goals patients expectations shorter term mainly concerned stress management nutritional advice information treatments effects conclusions overall patients gis agreed perceptions ibd treatments gis seemed concerned objective scientific measures remission whereas patients focused quality life social outcomes came evaluating therapy
incorporation detailed chemistry internal combustion engine ice simulations challenging due large number chemical species wide range chemical timescales involved complicated highly transient nature combustion process performance chemistry acceleration methods situ adaptive tabulation isat deteriorates dramatically ice simulations large variation accessed composition space study dynamic pruning strategy isat automated initial searching species method together adaptive reduction thresholds dynamic adaptive chemistry dac first proposed enhance capabilities isat dac transient ice simulations respectively isat dynamic pruning infrequently accessed tabulated points achieved pruning least recently used tabulated entries observed strategy improve computational efficiency chemistry compression post combustion stages order magnitude dac automated specification searching species based species reactivity characterized species rates change two stage heptane air autoignition illustrates dynamically select species importance according progress combustion process dynamic specification reduction thresholds based local thermodynamic conditions achieve additional reduction species reactions high temperature combustion static adaptive chemistry acceleration approach proposed improve chemistry calculation enhanced isat dac employed different combustion stages based encountered composition inhomogeneity reaction activity specifically isat employed compression post combustion stages dac employed combustion stage composition inhomogeneity significant found compared fixed coupled isat dac approach static adaptive approach improve efficiency chemistry calculations order magnitude compression post combustion stages factor combustion stage simulated hcci combustion primary reference fuel significant composition inhomogeneity proposed static adaptive approach achieves speed factor chemistry calculation species mechanism maintaining accurate predictions pressure temperature species three time efficient fixed coupled isat dac approach demonstrating great potential dynamic chemistry acceleration approaches ice simulations
research examines positive role consumer education diffusing innovative sustainable products isps enhance effectiveness consumer education campaign study explores type message framing best facilitate product adoption among three different approaches positive negative hybrid framing study also investigates consumer traits retailer attributes facilitate deter product adoption empirical application using biofuels shows negatively framed educational message highlighting negative impact gasoline versus biofuels effective leveraging social desirability product adoption economic disadvantages consumertraits positively associated adoption biobutanol environmental consciousness prosocial behavior openness new experiences whereas vertical individualism discourages adoption furthermore retailer choice attributes location payment convenience facilitate adoption retailer choice attributes based price servicescape cleanliness discourage adoption elsevier inc rights reserved
immense complexity mammalian brain largely reflected underlying molecular signatures billions cells brain transcriptome atlases provide valuable insights gene expression patterns across different brain areas throughout course development atlases allow researchers probe molecular mechanisms define neuronal identities neuroanatomy patterns connectivity despite immense effort put generating atlases answer fundamental questions neuroscience even greater effort needed develop methods probe resulting high dimensional multivariate data provide comprehensive overview various computational methods used analyze brain transcriptome atlases
background physical activity may play role preserving kidney health purpose study determine sedentary behavior associated incident chronic kidney disease ckd change kidney function older adults methods health aging body composition study prospective cohort well functioning older adults television watching measured self report serum cystatin used estimate glomerular filtration rate egfr ckd defined egfrml min discrete survival analysis used determine baseline television watching related year cumulative incidence ckd rapid decline kidney function results individuals reported watching television hours day higher risk incident ckd experiencing rapid decline kidney function compared individuals watched television hours day related either outcome conclusions high levels television watching associated declining kidney function mechanisms underlie association need study
fibular grafting impaction bone grafting faibg type minimally invasive hip preserving procedure stable clinical curative effects standard operation procedure however faibg requires difficult technique series complex procedures therefore discovery new methodology surgical guidance could lead accurate safe easily performed surgeries play crucial role promotion application faibg september july one surgeon performed faibg patients males females average age years range years using patient specific surgical guides patients underwent preoperative ray examinations mri scans surgery performed preoperative planning patient specific surgical guides computer aided design cad length bone tunnel bone mass percentage volume percentage surface area measured surgery ten fibular allografts screws placed patients diagnosed arco fhn implants successfully placed using patient specific surgical guides application patient specific surgical guide operating times min average min blood loss volumes average operative incision sizes average mean hospital stay cases followed months average months conclusions patient specific surgical guidance may enable intuitive precise preoperative planning hip preserving procedures
background aims proposed modification leaf size driven epidermal cell size balances leaf water supply determined veins transpirational demand generated stomata acclimation local irradiance aimed determine whether general pattern among plant species contrasting growth habits methods compared observed relationships leaf minor vein density stomatal density epidermal cell size leaf size four pairs herbs woody species families grown sun shade conditions modelled relationships assuming vein stomatal densities respond passively epidermal cell expansion leaf lignin content also quantified assess whether construction costs herbaceous leaf veins differ woody plants leaf mass fraction invested veins key results modelled relationships accurately described observed relationships indicating species ordinated changes density minor veins stomata mediated common relationship epidermal cell size vein density stomatal density little impact stomatal index ordination independent changes leaf size likely adaptive process driven significant proportion biomass invested veins center dot sun leaf dry weight center dot shade leaf dry weight relative costs venation increased shade intensifying selective pressure towards economizing investment vein density conclusions modulation epidermal cell size appears general mechanism among experimental species maintain constant ratio leaf anatomical traits control leaf water fluxes independently habit propose process may ordinate plasticity hydraulic supply demand majority eudicot angiosperms
background improve understanding autism spectrum disorder asd new zealand multi disciplinary research network minds minds created network established cohort self proxy reported individuals family members asd new zealand aim manuscript present new zealand minds minds autism spectrum disorder self reported cohort cohort short provide preliminary insights trends asd new zealand analysis diagnostic sociodemographic information members ages cohort majority carer reported method participants recruited via internet based questionnaire social network analysis used visually analyse mutual interactions cohort results observed well reported gender bias ethnic structure reflects new zealand recent census comorbidity patterns consistent epidemiological literature anxiety disorders depression epilepsy highly prevalent amongst individuals asd families conclusions first national large scale asd research cohort contains ethnic composition unique country anticipated multi disciplinary research approach cohort help inform health policies new zealand contribute international effort better understand asd elsevier ltd rights reserved
three phase common mode inductors widely used electric motor drives means limit ground current shaft voltage electromagnetic interference emission switching frequency power converters keeps increasing help high performance switching devices sic mosfets role inductors becoming increasingly important paper presents comprehensive analysis magnetic design sizing three phase inductors analytical calculation critical parameters leakage inductance stray capacitance flux density losses addressed paper design constraints determine size magnetic cores also shown finally systematic design procedure minimizes inductor size proposed verified
past investigations prenatal craniofacial growth largely relied histological sections studies taken measurements three dimensional representations reconstruction postmortem varying depth levels ultrasound know craniofacial growth studies done cleared stained specimens whole fetal heads study comprised human fetal head specimens cleared stained alizarin red alcian blue stored glycerol represented weeks gestation crown rump lengths ranging specimens cephalometrically analyzed norma frontalis norma lateralis notably included opportunity side side comparison cranial membrane bones progressively approached orbits maxilla mandible gradually grew wider likewise sagittal dimensions maxilla mandible increased continuously synchronically noted side side differences ranging another notable finding concerned inclination maxilla relative cranial base increased right left side first investigation presenting side side comparative measurements human fetal head specimens measurements essential quest toward validating findings imaging techniques mri importantly intrauterine sonography
introduction acquired angioedema rare disorder causing recurrent life threatening angioedema due decreased activity esterase inhibitor case report year old man presented hospital recurrent swelling hands lips tongue scrotum throat lab examination showed presence igm kappa monoclonal antibody additional analysis showed igm fraction autoantibody activity esterase inhibitor present confirmed diagnosis acquired angioedema presence lymphoplasmacytic lymphoma despite standard therapy increase episodes laryngeal oedema therefore decided perform non myeloablative allogeneic haematopoietic stem cell transplantation hla identical brother donor post transplantation course without complications five years following allosct complete remission without symptoms increased esterase inhibitor activity discussion case known treatment options severe acquired angioedema failed first case describing treatment severe acquired angioedema caused lymphoplasmacytic lymphoma allosct
many pid tuning rules available unstable first order plus time delay process however complex work optimal principles used along internal model control imc develop simple tuning rules pid controller tuning rules developed different time delay time constant ratios maximum sensitivity used selection imc tuning parameter different examples considered compare closed loop performances set point tracking disturbance rejection robustness proposed design also carried perturbations process parameters observed present tuning rules provide improved performances compared recently reported methods literature
robust analytical method required determination low molecular weight organic acids potential causes refinery internal combustion engine corrosion ion chromatographic method developed study allows determination acetic acid formic acid diesel oil mixtures motor oil volume fraction hydrophobic matrix automatically removed line matrix elution step organic solvent nonaqueous anion exchange analyte extraction acetic acid formic acid smallest acidic aliphatic naphthenic acids determined gradient anion exchange chromatography high capacity columns combination suppressed conductivity detection allowed selective sensitive determination typical recovery values acid matrices evaluated reproducibility less acid fortified samples
chikungunya virus growing human pathogen transmitted mosquito bite causes fever chills nausea vomiting joint pain headache swelling joints replication propagation depend protease activity chikungunya virus nsp protein cleaves nsp polyprotein replication complex individual functional units terminal segment papain structurally identical chikungunya virus nsp protease hence molecular dynamics simulations performed compare molecular mechanism proteases chikungunya virus snp protease shows conformational changes adopts alternate conformation however terminal segment two proteases identical active site scaffold conserved catalytic diad hence non peptide inhibitors papain used induced fit docking active site nsp assess binding mode addition peptides connect different domains protein chikungunya virus poly protein also subjected docking overall results suggest active site scaffold proteases possibility exists experimentally assess efficacy papain inhibitors inhibit chikungunya virus nsp
objective compare contraceptive knowledge use among women seeking emergency contraception inner city clinic began providing structured counseling offering day intrauterine device iud implant placement women seeking study design months months change clinic policy women aged wanted avoid pregnancy least months asked complete surveys immediately months clinic visit addition abstracted electronic medical record emr data women sought period used chi squared tests assess pre post differences survey emr data results surveys completed women clinic began offering structured counseling women accurate knowledge effectiveness iuds immediately months clinic visit addition women initiated iud implant use survey preintervention emr preintervention fewer contraceptive use survey preintervention emr months seeking emr data indicate day placement offered women received day iud received day iud reported iud use months months conclusions routine provision structured counseling offer day iud placement increases knowledge use iuds months women seek implications women seeking family planning clinics offered counseling highly effective reversible contraceptives option day contraceptive placement elsevier inc rights reserved
modern digital data production methods computer simulation remote sensing vastly increased size complexity data collected spatial domains analysis large spatial datasets scientific inquiry typically carried using gaussian process however nonstationary behavior computational requirements large spatial datasets prohibit efficient implementation gaussian process models perform computationally feasible inference large spatial data consider partitioning spatial region disjoint sets using hierarchical clustering observations finite differences measure dissimilarity intuitively directions large finite differences indicate directions rapid increase decrease therefore appropriate partitioning spatial region spatial contiguity resulting clusters enforced clustering voronoi neighbors following spatial clustering propose nonstationary gaussian process model across clusters allows computational burden model fitting distributed across multiple cores nodes methodology primarily motivated illustrated application validation digital temperature data city houston well simulated datasets supplementary materials article available online
widely accepted amyloid precursor protein app plays central role pathogenesis alzheimer disease addition app proposed functions numerous biological processes including neuronal proliferation differentiation migration axon guidance neurite outgrowth well synapse formation function however germline knockout app yields relatively subtle phenotypes brain development appears grossly normal thought due part functional compensation app family members type transmembrane proteins generated conditional mouse knockout app controlled temporally using creer tamoxifen administration show total cortical expression app reduced following tamoxifen administration embryonic time points critical cortical lamination results displacement reelin positive cells cortical plate concurrent elevation reelin protein levels results support role app cortical lamination demonstrate utility conditional knockout approach app deleted temporal control vivo new tool useful many different applications study app function across mammalian life span
background purpose recently developed total cerebral small vessel disease csvd score might appropriately reflect total burden severity csvd investigated whether total csvd score associated long term outcomes follow patients acute ischemic stroke methods total consecutive patients acute ischemic stroke underwent brain magnetic resonance imaging enrolled calculated total csvd score patient determining burden cerebral microbleeds cmbs high grade white matter hyperintensities hwhs high grade perivascular spaces hpvss asymptomatic lacunar infarctions alis recorded date cause death patients using data korean national statistical office compared long term mortality rate total csvd score using cox proportional hazards models results cmbs found subjects hwhs hpvss alis adjusting age sex variables significant atp univariate analysis total csvd score independently associated long term death causes hazard ratio per point confidence interval ischemic stroke per point hemorrhagic stroke per point fatal cardiovascular events per point conclusions total csvd score potential imaging biomarker predicting mortality follow patients acute ischemic stroke
understanding structural relaxations important task materials engineering biological food polymer pharmaceutical areas number theoretical models describing structural relaxation developed nevertheless complicity real systems requires detailed investigation development appropriate mathematical models present study trehalose wpi system used carbohydrate protein model ratio components varied range intervals experimental part consisted tree main sections sample preparation preliminary analysis water content water sorption freeze drying thermal dsc mechanical dma analyses rheology high water content systems water sorption isotherms plotted glass transition alpha relaxation temperature obtained system based wlf relationship strength parameter defined critical decrease tau logarithmic scale non universal constants wlf equation systems dependence strength parameter composition water content established elsevier ltd rights reserved
presence psychological distress negative impact cancer patients quality life also course disease slower recovery increased morbidity issues particular importance melanoma patients remain risk disease progression many years diagnosis study aimed investigate psychological distress coping strategies possible relationships demographic clinical features patients early stage melanoma follow investigation focused particular whether psychological profile differed patients different melanoma stages data patients melanoma tis stages tis patients melanoma iia iib stages gathered self administered survey compared using cross sectional design results evidenced high percentage anxiety distress symptoms whereas depressive symptoms seemed less frequent psychological distress higher women men patients higher educational level nevertheless significant differences found tis respect coping style patients sample adopted predominantly positive active strategies correlational analyses showed maladaptive coping strategies behavioral disengagement denial self distraction self blame strongly related increased levels psychological distress high presence anxiety distress symptoms relationship use negative coping strategies underline importance psychological distress screening also early stage including long term follow copyright wolters kluwer health inc rights reserved
recent years construction development country parks china rapidly widely gradually aroused people concerns lack country park resources evaluation system would called cpres paper china provide reference process country parks construction development basis studying country parks subtropical region china pearl river delta example combining country park unique properties characteristics authors tried preliminary establish country park resource evaluation system purpose propose reasonable flexible resource evaluation system country parks powerful tool would strengthen pertinence systemic country parks planning design management level would enrich improve country park planning design theory basic principle evaluation system descend resource evaluation several smaller specific evaluation factors according ahp analytic hierarchy process theory structure classification resources various values resources evaluation valuable impact factor core concept evaluation system resource value theory evaluated recreational value ornamental value scientific value ecological value cultural value evaluation result comprises ratings comments system mainly used assisting country park resources survey evaluation apply various country parks resource protection development planning design country park construction management etc
adsorption removal bisphenol bpaf aqueous solutions synthesized activated carbon alginate beads cetyltrimethyl ammonium bromide ctab studied using two ways traditional method two step first synthesized ctab modified ctab used remove bpaf adsorption one step method dispersed ctab wastewater followed removal bpaf accompanied synthesis ctab one step method showed better performance two step method achieving maximum removal bpaf kinetic studies adsorption isotherms indicated adsorption process bpaf one step method could expressed pseudo second order model dubininashtakhov isotherm respectively effects ionic strength inorganic ions bpaf adsorption also investigated furthermore hydrophobic interactions hydrogen bonds electron donor acceptor eda interactions discussed explain enhanced adsorption behavior bpaf ctab findings verified effectiveness removal bpaf wastewater high stability within five regeneration cycles elsevier inc rights reserved
aim study investigate effect newly developed silver nanoparticle aqueous suspensions nanoag nanoag mouse models mimicking ulcerative colitis crohn disease nanoag nanoag synthesized aqueous medium involvement tannic acid elucidate anti inflammatory activity semi chronic mouse models inflammation induced dextrane sulfate sodium addition drinking water intracolonic administration trinitrobenzenesulfonic acid used nanoag nanoag animal daily significantly ameliorated colitis dextrane sulfate sodium trinitrobenzenesulfonic acid induced mouse models colonic inflammation indicated reduced macroscopic ulcer microscopic scores anti inflammatory effect dependent shape diameter silver nanoparticles indicated weaker effect nanoag nanoag addition administration nanoag nanoag modulated colonic microbiota indicated reduced number escherichia coli clostridium perfringens increased number lactobacillus summarizing nanoag nanoag administered effectively alleviate colitis experimental models ulcerative colitis crohn disease mice therefore nanoag nanoag administered potential become valuable agents treatment inflammatory bowel diseases
herein present case years male total absence pulmonary veins pvs potentials beginning first procedure paroxysmal atrial fibrillation demonstrating dormant conduction left atrium pvs revealed adenosine triphosphate provocation relation incidence free atrial arrhythmias year follow complete isolation elimination multiple transient dormant conductions circular mapping catheter guide ablation
paper presents results model predictive controller mpc methodology applied case cooling system internal combustion engine end small spark ignition engine displacement volume equipped electric pump actuated controller independently engine speed goal proposed control achieve faster engine warm effective engine cooling much lower coolant flow rate one usually adopted bringing cooling system operate around onset nucleate boiling developed model predictive control application makes use lumped parameter model predicts heat transfer case single phase forced convection condition presence nucleate boiling performance proposed controller evaluated city driving part nedc homologation cycle replicated engine test rig results show proposed controller robust terms disturbance rejection effective reducing warm time authors published elsevier ltd ibis open access article license
spatial modulation control parameter describes instance major effects rough container boundary rayleigh benard convection threshold value bifurcation homogeneous basic state spatially periodic state provided analytically numerically taking one dimensional cubic quintic complex ginzburg landau equation real coefficients example threshold using poincare lindstedt expansion show quintic term affects stationary nonlinear solution nusselt number elsevier ltd rights reserved
crystal structure metal plays important role relationship macroscopic properties well atomic mechanisms structural change students need ability visualize planar crystal atomic packing features often find difficult thus research question student baseline knowledge misconceptions planar atomic packing features different metal structures measured well instruction promote conceptual change misconception repair answering question provide insight developing effective pedagogy crystal structures multiple choice survey six items developed using misconceptions students pencil paper sketches face centered cubic fcc body centered cubic bcc atoms planes pretests posttests survey administered students spring introductory materials engineering course misconceptions revealed included missing atoms extra atoms misplaced atoms non touching atoms touch touching atoms touch students difficulty solving increased planes bcc fcc structures details survey instrument results described paper
introduction many forms interstitial lung disease ild progress extensive fibrosis respiratory failure idiopathic pulmonary fibrosis ipf generally poor prognosis thoroughly studied past two decades many important discoveries made pertain genetic predisposition epidemiology disease pathogenesis diagnosis management additionally non ipf forms ild radiologic histopathologic manifestations mimic ipf making accurate diagnosis key providing personalized medicine patients pulmonary fibrosis areas covered manuscript discusses current knowledge pertaining genetics epidemiology pathogenesis diagnosis pulmonary fibrosis emphasis ipf material upon discussion based obtained various published texts manuscripts identified via literature searching pubmed expert commentary many genetic variants identified associated risk developing pulmonary fibrosis improved understanding influence genomic epigenomic factors development pulmonary fibrosis rapidly evolving many forms fibrosing ild similar radiologic histopathologic patterns yet different responses therapeutic interventions making accurate diagnosis specific forms pulmonary fibrosis increasingly important
realistic animation expressive human face great challenge computer graphics due human perception human faces complex costly time consuming process requiring great detail many aspects paper three stage method presented simplifies creation realistic facial animations transferring expressions videos onto models joint based system real time basis first stage covers preparation model joint based rig transfer second includes real time tracking human face single camera obtain positions facial landmarks also covers transfer relative movement data animate prepared model moving respective joints last stage covers recording animation using partially automated key framing technique presented method provides fast easy use affordable system produces visually satisfying facial animations
cone beam cbct musculoskeletal imaging would benefit method reduce effects involuntary patient motion particular continuing improvement spatial resolution cbct may enable tasks quantitative assessment bone microarchitecture detail size even subtle sub motion blur might detrimental propose purely image based motion compensation method requires fiducials tracking hardware prior images statistical optimization algorithm cma used estimate motion trajectory optimizes objective function consisting image sharpness criterion augmented regularization term encourages smooth motion trajectories objective function evaluated using volume interest voi single bone surrounding area motion assumed rigid complex motions addressed using multiple vois gradient variance found suitable sharpness metric application performance compensation algorithm evaluated simulated experimental cbct data clinical dataset motion induced artifacts blurring significantly reduced across broad range motion amplitudes structure similarity index ssim static volume used simulation studies quantify performance motion compensation studies translational motion ssim improved compensation compensation motion motion motion similar increase similar reduction artifacts observed benchtop experiment controlled translational motion anthropomorphic hand phantom ssim reconstruction static phantom improved motion application clinical dataset lower extremity showed dramatic reduction streaks improvement delineation tissue boundaries trabecular structures throughout whole volume proposed method support new applications extremity cbct areas patient motion may sufficiently managed immobilization imaging load quantitative assessment subchondral bone architecture
human faces specifically eyes play crucial role social nonverbal communication signal valuable information others therefore surprising studies investigated impact intergroup contexts motivations attention eyes ingroup outgroup members four experiments investigated differences eye gaze racial novel ingroups using eye tracker technology whereas studies demonstrated white participants attended eyes white compared black targets study showed similar pattern attention eyes novel ingroup outgroup faces studies also provided new evidence eye gaze flexible meaningfully influenced current motivations specifically instructions individuate specific social categories increased attention eyes target group members furthermore latter experiments demonstrated preferential attention eyes ingroup members predicted important intergroup biases recognition ingroup outgroup faces race bias study willingness interact outgroup members study implication findings general theorizing face perception individuation processes intergroup relations discussed
satellite remote sensing image often suffers haze degradation deteriorates significantly effect data intelligibility interpretability hence haze removal technique essential inferring high quality images clear visibility improve application value satellite images thin haze removal challenging task since estimation haze component easily affected ground features solve problem paper develops effective haze removal method single visible remote sensing image firstly haze considered additive contamination represented haze thickness map htm ground radiance suppressed htm grs htm proposed precise estimation haze distribution haze component band calculated via grs htm removed recover clear image several visible satellite images different resolutions tested validate effectiveness proposed method evaluation results qualitative quantitative assessments demonstrate proposed method superior traditional methods recover haze free image high quality elsevier rights reserved
paper concerns light electric vehicle application based magnetic transmission magnetic transmission capable offer extended speed range contains wheel motor integrates magnetic gear case magnetic gear multiplying wheel motor speed factor offering possibility high speed light without necessity supply electric motor high frequencies means efficiency improvement expected magnetic gear integrated topology study carried means numerical analysis performances wheel motor integrated magnetic gear evaluated finite element method
narcissists relative non narcissists seem regard narcissistic traits rudeness arrogance positively motivated cultivate traits said expect narcissists regard others narcissistic traits positively study participants completed survey responded measure trait narcissism rated likeability people possessed various narcissistic traits arrogant rude self centered indicated extent possessed narcissistic traits interestingly narcissists generally disagreeable harsh individuals rated others possessed narcissistic traits positively non narcissists furthermore mediation analysis revealed effect narcissism ratings mediated narcissists self reports possessing narcissistic traits thus study provides initial evidence narcissists accepting others narcissistic traits study implications understanding interpersonal intrapersonal consequences narcissism elsevier ltd rights reserved
improve access information patient history case emergency possible future data use emergency stored german electronic health card according wishes insured person basis german medical association developed emergency dataset offers possibility storing information existing diagnoses medications allergies medical implants information relevant emergency present study emergency dataset tested regard usability potential benefits perspective clinicians emergency physicians paramedics test emergency dataset two phase exploratory study conducted phase study primary care physicians completed total emergency datasets phase study datasets evaluated emergency medicine perspective clinicians emergency physicians paramedics basis fictitious emergency scenarios whole validation process performed purely paper clinicians emergency physicians paramedics rated emergency dataset cases reviewed great great benefit data fields medication diagnosis received highest benefit ratings study results indicate high potential benefits emergency dataset real patient care situations contribution optimisation patient safety expected extensive distribution
flow power law fluids include shear thinning shear thickening well newtonian special case networks interconnected elastic tubes investigated using residual based pore scale network modeling method employment newly derived formulae two relations describing mechanical interaction local pressure local cross sectional area distensible tubes elastic nature considered derivation formulae model used describe shear dependent flows mainly viscous nature behavior proposed model vindicated several tests number special limiting cases results verified quantitatively qualitatively model first kind incorporates one major nonlinearity corresponding fluid rheology conduit mechanical properties non newtonian effects tube distensibility formulation implementation performance indicate model enjoys certain advantages existing models exact within restricting assumptions model based easy implementation low computational costs reliability smooth convergence proposed model therefore used alternative existing newtonian distensible models moreover stretches capabilities existing modeling approaches reach non newtonian rheologies
children frequently experience encouragement pressure eat likely exhibit less favorable eating behaviors dietary outcomes siblings encourage pressure eat mealtimes role mothers shaping sibling mealtime interactions understood objective study examine association behavior mothers siblings mealtimes associations maternal presence maternal engagement children mealtimes encouragements eat delivered child sibling examined children aged years videotaped eating routine evening meal home one sibling present encouragement eat delivered index child sibling maternal presence non food related food related maternal engagement coded videotapes poisson regression showed maternal presence associated fewer encouragements eat index child sibling rate ratio confidence interval type maternal engagement independently associated number encouragements eat index child sibling maternal engagement food related associated fewer encouragements eat maternal engagement food related associated encouragements eat future studies may explore sibling interactions may mediate links maternal behavior mealtimes children health related outcomes elsevier ltd rights reserved
background little known mechanistic basis exercise intolerance characteristic patients respiratory disease lack clearly defined distinct patient groups limits interpretation many studies purpose pilot study investigate pulmonary oxygen uptake dot response potential determinants patients emphysema idiopathic pulmonary fibrosis ipf methods following ramp incremental test determination peak dot gas exchange threshold six emphysema years fev five ipf years fev ten healthy control participants years completed three repeat heavy intensity exercise transitions cycle ergometer throughout transition pulmonary gas exchange heart rate muscle deoxygenation hhb patients assessed continuously subsequently modelled using mono exponential dot hhb without time delay results dot phase time constant tau differ ipf emphysema groups significantly slower healthy controls emphysema ipf control slower emphysema relative ipf groups significantly slower controls emphysema ipf control contrast neither hhb tau hhb ratio differed patient groups conclusions slower dot kinetics emphysema ipf may reflect poorer matching delivery utilisation findings extend understanding exercise dysfunction patients respiratory disease may help inform development appropriately targeted rehabilitation strategies
simplify deployment maintenance ambient intelligence solutions important enable large scale deployment maximize use benefit solutions mature ambient intelligence solutions emerge market result intensive investment research research targets mainly accuracy usefulness usability aspects solutions still possibility adapt different environments ease deployment maintenance ongoing problems ambient intelligence existing solutions require expert move site order install maintain systems therefore present paper attempt enable quick large scale deployment discuss lessons learned approach automating deployment process order performed ordinary people also introduce solution simplifying monitoring maintenance installed systems
study sought develop comprehensive measure fitness predictive injury risk used fire service assess individual level health fit duty status retrospective occupational cohort career fire service employees observed years equally weighted score comprehensive fitness calculated based cardiovascular fitness muscular strength endurance flexibility body composition repeated measures survival analyses used estimate risk injury sprain strain exercise related injuries relation comprehensive fitness well distributed comprehensive fitness score developed distinguish three tiers overall fitness status intraclass correlations identified flexibility total grip strength percent body fat resting heart rate reliable fitness metrics push ups sit ups aerobic capacity demonstrated poor reliability general individuals lower comprehensive fitness status increased injury risk injury compared fit individuals risk injury times likely least fit individuals compared individuals top fire fitness category increasing restricted sprains strains year analysis clinical occupational health assessments enabled development relevant metric relating comprehensive fitness risk injury results consistent previous studies focused cardiorespiratory fitness also less susceptible inter individual variability discrete measurements
propose support vector regression approach symbol detection large mimo systems employing spatial multiplexing explore applicability machine learning algorithms particular support vector machines address one recent research problem communications machine learning capability exploited achieve fast detection large dimension systems performance proposed method compared lattice reduction aided detection currently popular choice improvement terms bit error rate demonstrated sparse formulation problem matrix reduces computational complexity enables faster detection proposed detection algorithm tailored address uncorrelated correlated channel conditions well
background vitamin mineral deficiencies affect two million people worldwide based recent scientific evidence low effectiveness current strategies world health organization recommended home fortification foods multiple micronutrients powder mnp new strategy prevent control anaemia childhood systematic review assessed adherence acceptability home fortification multiple micronutrients powder mnp complementary feeding methods adherence assessed based number percentage prescribed sachets consumed acceptability assessed according perceptions caregivers children mnp results summary studies indicated home fortification mnp good adherence ranging prescribed sachets mnp well accepted caregivers caregivers reported side effects children taking mnp many studies diarrhoea vomiting constipation common conclusions home fortification mnp good adherence acceptability infants higher adherence non daily flexible administration regimens characteristics target population increased diarrhoea burden considered planning public health programs long term use mnp acceptability mnp satisfactory use perceived beneficial effects children health considered
serum testosterone reduced men cirrhosis levels falling liver disease advances testosterone important anabolic hormone effects muscle bone hematopoiesis many features advanced liver disease similar seen hypogonadal men including sarcopenia osteoporosis gynecomastia low libido however relative contribution testosterone deficiency symptomatology advanced liver disease well established recently demonstrated low testosterone men cirrhosis associated increased mortality independent classically recognized prognostic factors model end stage liver disease score several small clinical trials examined role testosterone therapy men cirrhosis none resolved issue whether testosterone beneficial however men organic hypogonadism due structural hypothalamic pituitary testicular axis disease testosterone therapy shown improve muscle mass bone mineral density increase hemoglobin reduce insulin resistance despite initial concerns linking testosterone hepatocellular carcinoma recent data suggest risk overstated therefore strong rationale assess efficacy safety testosterone therapy cirrhosis well designed randomized controlled trials
paper presents design development microcontroller based wireless data acquisition system study feasibility different existing methodologies linked field data acquisition remote photovoltaic water pumping systems various existing data transmission techniques studied especially satellite radio global system mobile communication gsm general packet radio service gprs system hardware software application test performance described system used reading storing analyzing information several water pumping stations situated remote areas arid region south tunisia remote communications based gsm network particular short text message service sms integrated system compile complete database different parameters related water pumping systems tunisia data could made available interested parties internet
revisit classic problem spreading piece information group fully connected processors suitably adding small dose randomness protocol gasieniec pelc parallel comput derive first time protocols use linear number messages correct even arbitrary number adversarially chosen processors participate process iii high probability asymptotically optimal runtime least arbitrarily small constant fraction processors working addition protocols require system synchronized processors simultaneously woken time zero fully based push operations need priori estimate number failed nodes protocols thus overcome typical disadvantages two known approaches algorithms based random gossip typically needing large number messages due unorganized nature algorithms based fair workload splitting either time efficient require intricate preprocessing steps plus synchronization
blood glucose levels controlled well known physiological feedback loops high glucose levels promote insulin release pancreas turn stimulates cellular glucose uptake low blood glucose levels promote pancreatic glucagon release stimulating glycogen breakdown glucose liver healthy people control system remarkably good maintaining blood glucose tight range despite many perturbations system imposed diet fasting exercise medications stressors type diabetes mellitus tdm results loss insulin producing cells pancreas beta cells cells serve sensor glucose levels actuator insulin glucagon release control physiological feedback loop although idea rebuilding feedback loop seems intuitively easy considerable control mathematics involving multiple types control schemawere necessary develop artificial pancreas still function well evolved control mechanisms highlight tools control engineering used mimic normal glucose control artificial pancreas constraints trade offs clinical consequences inherent various types control schemes tdm viewed loss normal physiologic controls many disease states reason introduce basic concepts control engineering applicable understanding pathophysiology disease development physiologically based control strategies treatment
work resulted multidisciplinary project supported university porto concerning areas architecture engineering design established two phases project manufacture project includes modelling components design architectural proposes manufacture deals different composite materials engineering expeditious construction solutions phases allowed creating temporary shelter facilities executed resources residual local materials appropriated situations natural catastrophes social action needs
introduction order establish use national registry several hungarian hematology centers collected data myeloproliferative neoplasia patients aim recent publication analysis data registered essential thrombocythaemic patients method online electronic registry established using world health organization diagnostic criteria thrombotic risk evaluated according landolfi stratification results data essential thrombocythaemic patients hungarian hematology centers entered date june used analysis patients followed median years epidemiologic data age gender thrombotic events prior diagnosis similar literature thrombotic events anagrelide treated patient hydroxyurea aspirin treated patients compared major arterial venous events similar groups fivefold less minor arterial venous events anagrelide group thrombotic incidence diagnosis influenced medication thrombotic events diagnosis conclusions anagrelide significantly decreased number patients experiencing minor arterial minor venous thrombosis hydroxyurea aspirin despite treatment risk thrombotic events diagnosis remained high significantly increased patients thrombosis diagnosis
longitudinal case control study acute fracture associated low serum testosterone transient men assessment gonadal status part assessment bone fragility measurement testosterone early period fracture may overestimate prevalence androgen deficiency measurement circulating testosterone recommended evaluation bone fragility men since acute illness transiently decrease circulating testosterone quantified association acute fracture serum testosterone levels case control study conducted involving men radiologically confirmed minimal trauma fracture presenting tertiary referral hospital age matched men without history minimal trauma fracture serving controls follow testosterone levels months baseline available cases controls results expressed median interquartile iqr range compared controls cases lower total testosterone nmol cases treated inpatients lower testosterone levels cases treated outpatients nmol group differences calculated free testosterone cft comparable group differences follow cases median increased nmol nmol shbg remained unchanged cases low testosterone nmol cft pmol presentation reclassified androgen sufficient follow unchanged controls low testosterone levels men presenting acute fracture may least part due acute fracture associated stress response avoid diagnosis evaluation testosterone deficiency deferred recovery acute event
given large amount information encounter often must prioritize information attempt remember although critical everyday functioning relatively little research focused people prioritize encoding information recent research shown people selectively remember information assigned higher relative lower importance however mechanisms underlying prioritization process consequences processes still well understood present study sought better understand prioritization processes whether implementing processes comes cost memory accuracy increasing false memories used modified form deese roediger mcdermott drm paradigm participants studied drm lists list paired low medium high point values experiment encoding higher values led false memories encoding lower values possibly prioritizing information enhanced relational processing among high value words experiment disrupting relational processing selectively reduced false memories high value words finally experiment facilitating relational processing selectively increased false memories low value words findings suggest prioritizing information enhance true memory process concomitantly increases false memories furthermore mechanism underlying prioritization processes depends ability successfully engage relational processing thus prioritize encoding incoming information come cost terms accurate memory
substantial evidence indicates infants expect agents move directly goals obstacles block paths representations articulate expectation robustness characterized across three experiments total month old infants responded novel curvilinear action trajectory basis efficiency accord expectation agent move goal least costly path environment affords infants expected minimally costly action presented novel constraint extended expectation agents previously acted inefficiently infants understanding goal directed action explained alone sensitivity specific features agent actions agents tend move straight paths along supporting surfaces facing goals directly extrapolations agents past actions future ones agent took shortest path object past continue future instead infants reasoning efficiency accords overhypothesis agents minimize cost actions elsevier rights reserved
paper investigates feasibility developing predictive rating method optimize line rating underground transmission lines based weather forecast information transmission lines overhead underground essential indispensable parts electric grid basically transfer energy production point needed line rating defined line maximum capacity transfer electric current power safely reliably certain constraints criteria ensure safe operation rating classically calculated according worst case scenario conductor temperature rise would remain within specified limit unfavorable conditions obviously approach leads conservative results leaving line mostly underutilized throughout life span order optimize line utilization ambient adjusted rating recently dynamic line rating methods developed instance dynamic line rating real time data used determine instantaneous line rating investigated necessity possibility developing predictive model underground transmission lines employing weather forecast information would enable line operators owners anticipate optimized line ampacity maximum rating next days proposed basic model builds upon already developed well documented analogy thermal electrical circuits yet incorporates time varying source account constantly changing ambient temperature deterministic weather forecast information collected environment canada
laboratory elasticity strength materials school engineering barcelona upc gained wide experience pallet rack testing recent years gathered comprehensive set experimental results upright cross sections subject compression twenty different pallet rack steel profiles tested information valuable allows evaluate different methods alternative testing design option paper two alternative methods considered analytical applying european standard traditional method involves effective width determination part section subject compression numerical applying finite element analysis including non linear material geometrical behaviour results methods compared experimental ones research reveals even though european standard accept experimental method perforated sections theses two methods give good accuracy good tools stage design optimization elsevier ltd rights reserved
growing evidence neuroimaging studies suggest emotional cognitive processes interrelated anatomical key structures context dorsal rostral ventral anterior cingulate cortex dacc rvacc however time course activations within regions emotion cognition interactions disentangled present study used event related potentials erp standardized low resolution electromagnetic tomography sloreta region interest roi source localization analyses explore time course neural activations within dacc rvacc using modified emotional stroop paradigm erp components related stroop conflict late negativity analyzed time course brain activations dacc rvacc strikingly different pronounced initial responses rvacc followed increased dacc activity mainly late negativity window moreover emotional valence modulated earlier stage within rvacc region higher neural activations positive compared negative neutral conditions emotional arousal modulated late negativity stage firstly significant arousal congruence erp effect significant higher current density low arousal condition within dacc using sloreta source localization substantial differences activation time courses dacc rvacc could found emotional stroop task suggest late negativity within dacc emotional arousal modulated processing response conflict reflected correlation gaussian current density dacc
supplemental nutrition assistance program snap provides critical nutrition assistance million americans month low income older adults older disabled participants experience additional budgetary constraints high pocket medical expenses recent years states adopted standard medical expense deduction smed senior disabled beneficiaries making easier report medical expenses snap application process conduct descriptive national analysis shows increases benefit levels reporting medical expenses states implemented smed present descriptive findings medicare claims data among sample low income older adults need food assistance georgia average medical expenses among sample approach per month whereas persons diagnosed multiple chronic conditions exceed per month policy implications analysis include need states consider adoption smed alternative estimating approaches leading increases benefit levels neediest beneficiaries decreases administrative burden among state agencies present two possible policy approaches states might take receive approval changes department agriculture
background work families families risk within field music therapy developing last decade diminish risk unhealthy child development families emotionally neglected children need help improve emotional communication develop healthy parent child interactions researchers investigated effect music therapy either parent child study investigated effect music therapy observed interaction parent child within field child protection objective purpose study investigate effect dyadic music therapy intervention observed parent child interaction mutual attunement nonverbal communication emotional parental response self reported parenting stress self reported parent child relationship families risk families emotionally neglected children ages years method randomized controlled trial study conducted family care center denmark eighteen parent child dyads randomly assigned receive weekly music therapy sessions credentialed music therapist treatment usual observational measures parent child interaction self reported measures parenting stress parent child relationship completed baseline months post baseline assessment results results study showed dyads received music therapy intervention significantly improved nonverbal communication mutual attunement similarly parents participated dyadic music therapy reported significantly less stressed mood child significantly improve parent child relationship terms better talking understanding children parents receive music therapy groups significantly improved terms increased positive decreased negative emotional parental response parenting stress stress general significant group differences self perceived autonomy attachment parental competence conclusions dyadic music therapy intervention examined study improved emotional communication parent child interaction sessions considered viable treatment alternative supplement families risk families emotionally neglected children
one major challenges pig production managing digestive health maximize feed conversion growth rates also minimize treatment costs warrant public health great interest development useful tools intestinal health monitoring investigation possible prophylactic therapeutic intervention pathways great variety vivo vitro intestinal models study developed recent years understanding complex system intestinal system study physiology pathology easy task analysis complex system requires use systems biology techniques like proteomics however correct interpretation results maximize analysis performance careful selection model study proteomic platform required study system especially important pig species whose farming requires careful management husbandry procedures regarding feeding nutrition incorrect management pig digestive system leads directly economic losses related suboptimal growth feed utilization appearance intestinal infections particular diarrhea furthermore species suitable experimental model human studies proteomics risen one promising approaches study pig review describe useful models research porcine different proteomic platforms available overview recent findings pig proteomics also provided
software engineering mission command two separate similar fields instances complex problem solving environments ever changing requirements research hypothesis modifications agile software development based inspirations mission command improve software engineering process terms planning prioritizing communication software requirements progress well improving overall software product targeted scrum modification traditional scrum based three inspirations mission command end state line effort targeting inspirations led introduction product design meeting modifications current scrum meetings artifacts tested research hypothesis using semester long undergraduate level software engineering class students developed two software projects one using traditional scrum using targeted scrum assessed well methodologies assisted software development teams planning developing software architecture prioritizing requirements communicating progress also evaluated software product produced methodologies found targeted scrum better assisting software development teams planning prioritization requirements however targeted scrum negligible effect improving software development teams external internal communications finally targeted scrum impact product quality top performing worst performing teams targeted scrum assist product quality teams middle performance spectrum
objective part series papers chronobiology mood disorders malhi kuiper acta psychiatr scand suppl time managed depression emerging role chronobiology malhi acta psychiatr scand suppl examining chronobiology context depression article examines recent western clinical practice guidelines cpgs treatment depression respect recommendations make particular regards chronobiological treatments briefly considers implications methodology approach method five international treatment guidelines published past years identified representing north american european views chosen guidelines reviewed authors relevant recommendations distributed discussion subsequent synthesis results current guidelines address chronobiology detail chronotherapeutic recommendations tentative although agomelatine considered option major depression bright light therapy seasonal affective disorder sleep deprivation routinely recommended conclusion recommendations limited lack reliable therapeutic markers chronotherapeutics current evidence supports use light therapy seasonal depression non seasonal depression insufficient evidence support reliance chronotherapeutics existing treatment modalities
background students problems transitioning nursing education nursing instructors impact transition using active coaching role objectives objective study evaluate early academic coaching intervention helped students progress beginning first nursing semester student perceptions intervention also explored design study followed descriptive non experimental design nonprobability convenience sample used settings four year bachelor nursing program private college central pennsylvania participants sample included first semester students enrolled first nursing course method first five weeks semester students asked meet nursing course instructors five minute check ins students coached time management study skills access resources stress management upcoming assignments grades online survey also sent students regarding check experience results student coaching needs changed throughout five week intervention first students heavily needed time management coaching study skill coaching steady need second fifth week stress management coaching increased last week data collection along time first exams students attended four five weekly visits higher first test scores higher overall course grades majority students reported benefits attending check visits including organization study skills feeling connected instructor conclusions students reported overall benefit attending check visits course instructors able intervene early students academic problems help students gain access resources although check ins brief visits impact instructors time check weeks elsevier ltd rights reserved
mosquito borne diseases threat public health primarily caused lack clean water access poor sanitation way overcome problems sixth goal sustainable development goals sdg imperative improve sanitation practices access clean water supplies safe sustainable way considering weak points current centralized water sanitation systems way achieve sdg finding sustainable approaches alternative unrealistic unreliable uneconomical water supplies dams groundwater bottled water dangerous sanitation practices open defecation essential protect public health recently spreading diseases zika ebola malaria etc case developed novel integrated systems rainwater harvesting systems waterless toilets along self cleaning ponds paper suitable key elements roles new water sanitation management introduced together assessments key system identified public residential zones comparisons current treatment plants using economic analysis discussed reasonable parameters elsevier ltd rights reserved
addicted patients social cognition deficits require therapists special skills ensure treatment success specific remediation techniques teach addicted patients look relevant emotional cues interacting people tested adjunctive treatment
research seeks investigate antecedents government adoption small island developing state extended model comprising unified theory acceptance use technology government adoption model employed results cross sectional survey citizens show performance expectancy facilitating conditions perceived value positively related behavioural intention computer self efficacy shown significant negative relationship behavioural intention resistance change results demonstrate trustworthiness inversely related resistance change small island developing states engage proper awareness campaigns government services offered focusing efforts citizens aged years old obtain critical mass users website design information quality improved paying particular attention security privacy thereby increasing trust reducing resistance change elsevier ltd rights reserved
tested hypothesis changes serum cartilage oligomeric matrix protein comp tumour necrosis factor tnf interleukin high sensitivity reactive protein hscrp concentration regular endurance training running marathon race depend body mass index bmi marathon performance blood samples collected runners varying bmi running experience week marathon training programme immediately marathon race serum biomarker concentrations bmi marathon finishing time measured mean confidence interval changes immediately marathon comp tnf hscrp mean changes immediately marathon comp tnf hscrp bmi affect changes biomarker concentrations differences marathon finishing time explained variability changes serum hscrp variability changes serum comp recovery marathon race slower marathon finishing time higher bmi modulates increases pro inflammatory markers cartilage markers following marathon race
previous studies shown seeing another person live direct averted gaze results enhanced skin conductance responses scrs indicating autonomic arousal greater relative left sided frontal activity electroencephalography asymmetry alpha band power associated approach motivation studies however stimulus persons neutral expression real life social interaction eye contact often associated smile another signal sender approach related motivation smile could therefore enhance affective motivational responses eye contact present study investigated whether facial expression neutral social smile would modulate autonomic arousal frontal eeg alpha band asymmetry seeing direct averted gaze faces presented live liquid crystal shutter results showed scrs greater direct averted gaze effect gaze direction pronounced smiling neutral face however study gaze direction facial expression affect frontal eeg asymmetry although gaze direction found marginally significant correlation degree overall bias asymmetric frontal activity degree direct gaze elicited stronger left sided frontal activity averted gaze
study focuses discrete time hammerstein system investigate identification quantised inputs quantised output observations discussion system identifiability parameterising static non linear function three step algorithm proposed estimate unknown parameters identifiable system strong convergence mean square convergence rate algorithm established shown asymptotic efficiency achieved terms cramer rao lower bound selecting suitable transformation matrix numerical simulation given demonstrate effectiveness algorithm
well known imc pid controller tuning gives fast improved set point response slow disturbance rejection modification proposed imc pid tuning rule improved disturbance rejection modified imc pid tuning rule method developed obtain imc pid setting closed loop mode without acquiring detailed information process proposed method based closed loop step set point experiment using proportional controller gain direct approach find pid controller setting similar classical ziegler nichols closed loop method based simulations wide range first order delay processes simple correlation derived obtain modified imc pid controller settings closed loop experiment method controller gain function overshoot obtained closed loop set point experiment integral derivative time mainly function time reach first peak overshoot simulation conducted broad class processes controllers tuned degree robustness measuring maximum sensitivity order obtain reasonable comparison pid controller settings obtained proposed tuning method show better performance robustness two step tuning methods broad class processes also applied temperature control loop distillation column model result compared open loop tuning method gives robust fast response
persistent genital arousal disorder pgad may coexist restless legs syndrome overactive bladder syndrome share similarities conditions thus new term restless genital syndrome rgs proposed purpose paper present case pgad including description etiology diagnostics treatment disorder described patient meets criteria pgad organic lesions within nervous urogenital system excluded psychogenic background syndrome assumed case patient diagnosed personality disorder predominance dependent personality traits emotional lability failure pharmacological treatment systemic psychotherapy cognitive behavioral elements initiated moderate effect
letter new floating inductance simulator circuit presented proposed structure consists one grounded capacitor without external resistors two different active elements active elements dual output current controlled current conveyor cccii operational transconductance amplifier ota proposed inductance simulator tuned electronically changing biasing current ccciis changing current ota moreover circuit require conditions component matching good sensitivity performance respect tracking errors application proposed inductance simulator used construct fourth order resistively terminated band pass filter theoretical analysis verified spice simulation results elsevier gmbh rights reserved
need ensuring safety energy supply well tendency reduce greenhouse gas emissions led greater use energy efficient technologies renewable energy sources cogeneration combined production heat electricity one high efficiency technologies losses primary energy less losses separate generation heat power consequently member states district heating based cogeneration plants using one renewable energy sources fuel cogeneration plants provide additional advantage technologies provide double carbon reduction benefit biomass suitable using cogeneration technologies based steam turbine gas turbine combined cycle internal combustion engine stirling engine organic rankine cycle biomass one important renewable energy sources serbia various estimations suggest serbia potential ktoe wood biomass ktoe agricultural biomass serbia significant potential use biomass primarily small cogeneration plant ensure energy supply wood processing industry farms parts municipalities level utilization biomass cogeneration plants potential biomass utilization small cogeneration plants serbia well commercially available cogeneration technologies presented paper
well known activity level measurement fusion rule two crucial factors image fusion existing fusion methods either spatial domain transform domain like wavelet activity level measurement essentially implemented designing local filters extract high frequency details calculated clarity information different source images compared using elaborately designed rules obtain clarity focus map consequently focus map contains integrated clarity information great significance various image fusion issues multi focus image fusion multi rhodal image fusion etc however order achieve satisfactory fusion performance two tasks usually difficult finish study address problem deep learning approach aiming learn direct mapping source images focus map end deep convolutional neural network cnn trained high quality image patches blurred versions adopted encode mapping main novelty idea activity level measurement fusion rule jointly generated learning cnn model overcomes difficulty faced existing fusion methods based idea new multi focus image fusion method primarily proposed paper experimental results demonstrate proposed method obtain state art fusion performance terms visual quality objective assessment computational speed proposed method using parallel computing fast enough practical usage potential learned cnn model type image fusion issues also briefly exhibited experiments elsevier
purposes study assess child abuse professionals nonprofessionals knowledge scientific research findings relevant forensic child sexual abuse csa evaluations describe associations child abuse professionals levels research knowledge education experience item multiple choice test administered child abuse professionals nonprofessionals undergraduate college students brazil united states nonprofessionals average percent correct significantly different would expected random guessing professionals average percent correct higher nonprofessionals random guessing average percent correct score sample psychologists higher average score professionals professionals educational level measured highest academic degree obtained positively associated percent correct scores spearman rho controlling educational attainment professional experience measured total number csa evaluations performed weakly associated percent correct scores partial percent correct scores low nonprofessionals professionals participants study uninformed misinformed scientific research findings important conducting optimal forensic csa evaluations making accurate judgments validity sexual abuse allegations elsevier ltd rights reserved
skin dendritic cells patients atopic dermatitis well characterized less known peripheral blood precursors aim study investigate phenotypic features chemokine production myeloid pre dendritic cells patients vivo stimulation staphylococcus enterotoxin thymic stromal lymphopoietin representing like microenvironment expression cell surface markers measured flow cytometry chemokine production monitored chemokine antibody array confirmed enzyme linked immunoassays pre dendritic cells expressed higher levels epsilon maturation activation markers tended altered produced ccl maturation related ccl chemokines higher level controls production ccl ccl significantly higher even without specific stimulation production ccl ccl significantly higher stimulation results indicate circulating pre dendritic cells premature bear atopic characteristics even without tissue specific stimulation suggesting development influenced skin microenvironment even earlier local milieu blood
present work approaches relatively new optimization scheme called quasi oppositional symbiotic organism search qosos algorithm first time find optimal effective solution load frequency control lfc problem power system symbiotic organism search sos algorithm works effect symbiotic interaction strategies adopted organism survive propagate ecosystem avoid suboptimal solution accelerate convergence speed theory quasi oppositional based learning obl integrated original sos used solve lfc problem demonstrate effectiveness qosos algorithm two area interconnected power system nonlinearity effect governor dead band generation rate constraint considered first instant followed four area power system showing consequence load perturbation structural simplicity robust performance acceptability well popular proportional integral derivative pid controller enforce implement secondary controller present analysis success qosos algorithm established comparing dynamic performances concerned power system obtained recently published algorithms available literature furthermore robustness sensitivity analyzed concerned power system judge efficacy proposed qosos approach
review relatively immature field automated image analysis ray cargo imagery increasing demand automated analysis methods assist inspection selection containers due ever growing volumes traded cargo increasing concerns customs security related threats smuggled across borders organised crime terrorist networks split field classical pipeline image preprocessing image understanding preprocessing includes image manipulation quality improvement threat image projection tip material discrimination segmentation image understanding includes automated threat detection atd automated contents verification acv identify several gaps literature need addressed propose ideas future research current literature sparse borrow single view multi view ray baggage domains characteristics common ray cargo
paper present hardware software coattack hijack program flow microcontrollers basic idea skip instructions using multiple fault injection microcontrollers cooperation software attack focus buffer overflow bof attacks together multiple fault injection proposed attack applied program code typical software countermeasure bof attacks attack manipulates program control flowby skipping specific instructions related countermeasure thus subsequent bof attack code successfully executed microcontroller show effectiveness proposed attack experiments using bit avr atmega microcontroller bit arm cortex microcontroller target software equipped countermeasure limiting size user input bof attacks result showed attack overwrite return address stored stack call arbitrary malicious function also propose software countermeasure attack prove validity examining possible instruction skips
food potent natural reward food intake complex process reward gratification associated food consumption leads dopamine production turn activates reward pleasure centers brain individual repeatedly eat particular food experience positive feeling gratification type repetitive behavior food intake leads activation brain reward pathways eventually overrides signals satiety hunger thus gratification habit favorable food leads overeating morbid obesity overeating obesity stems many biological factors engaging central peripheral systems directional manner involving mood emotions emotional eating altered mood also lead altered food choice intake leading overeating obesity research findings human animal studies support two way link three concepts mood food obesity focus article provide overview complex nature food intake various biological factors link mood food intake brain signaling engages peripheral central nervous system signaling pathways directional manner obesity
tig process hot wire addition described process highly productive comparison conventional tig process cold wire achieved large deposition rates low dilution percentages characteristics permit process optimum alternative cladding applications many options electrical circuits configurations heat addition wire tig hot wire process highlighting utilization continuous pulsed current alternating current present paper studied two configurations electrical circuit heat addition materials theory provoke different behaviors welding arc therefore geometrical properties welding bead first analysis done welding arc demonstrate heat wire continuous constant current generated permanent magnetic blow arc according trials made direction intensity magnetic blow depend polarity current value heat wire macrographic analysis weld beads demonstrated best results tests made hot wire achieving dilutions wire velocity min power heat wire using welding velocity min
objective people major depressive disorder mdd may pre onset stage bipolar disorder early identification prevention efforts may feasible aimed identify rates characteristics predictive transition prospective follow studies people mdd methods using systematic search strategy identified studies diagnostic ascertainment mdd adequate standard minimum length follow months examined incidence point prevalence pooled odds ratios baseline predictors results unique publications included nearly quarter adults adolescents mdd followed mean length years developed greatest risk transition first years meta analysis identified transition mdd predicted family history earlier age onset depression presence psychotic symptoms conclusions participants identified risk factors merit closer observation may benefit prevention efforts especially outcomes broader considered
polycomb repressive complex prc critical regulator normal tissue homeostasis well tumorigenesis ezh enzymatic subunit prc histone methyltransferase functions regulation gene silencing ezh overexpression first identified prostate breast cancers associated poor clinical outcome subsequently gain loss function mutations ezh identified various tumors including hematological malignancies implicating ezh either oncogene tumor suppressor gene depending cancer type molecular mechanisms underlying multifaceted function ezh analyzed extensively however ezh dysregulation functionally integrated multiple epigenetic events context dependent manner precise manner ezh dysregulation impacts pathogenesis hematological malignancies remains clarified perspective describe recent findings pathogenic role ezh hematological malignancies may provide insights treatment cancers ezh dysregulation development novel therapies targeting epigenetic regulators
concerns children weight steadily risen alongside manufacture use myriad chemicals one class chemicals known metabolic disruptors interfere human endocrine metabolic functioning specific concern children health development article examines effect residential concentrations metabolic disrupting chemicals children school performance first time census tract level ambient concentrations known metabolic disruptors come environmental protection agency national air toxics assessment measures drawn survey primary caretakers grade children paso independent school district paso usa mediation model employed examine two hypothetical pathways ambient level metabolic disruptors child home might affect grade point average results indicate concentrations metabolic disruptors statistically significantly associated lower grade point averages directly indirectly body mass index findings study practical implications environmental justice research chemical policy reform
pooling designs fundamental tools many applications biotechnology network security many famous pooling designs constructed mathematical structures containing relations recently pooling designs constructed intersecting relation proposed guo wang constructing intersecting relation provides much better error tolerance capabilities study error tolerance capabilities pooling designs constructed intersecting relation combinatorial structures proposed yachkov elsevier rights reserved
investigation paper dimensional korteweg vries type equation describe propagation nonlinear waves shallow water waves surface internal waves virtue bell polynomials symbolic computation auxiliary independent variable bilinear forms backlund transformations soliton solutions obtained solitonic propagation elastic collisions among two three solitons discussed analytically graphically seen collision solitonic shapes amplitudes keep invariant except phase shifts smaller amplitude soliton moves faster overtakes larger
altered sensory perception found patients autism spectrum disorders asd might related aberrant sensory perception thresholds used well established standardized quantitative sensory testing qst protocol german research network neuropathic pain investigate somatosensory parameters including thermal tactile detection pain thresholds asd adults matched healthy controls normal values group differences somatosensory detection pain thresholds two asd patients showed paradoxical heat sensations another two asd subjects presented dynamic mechanical allodynia somatosensory features absent controls findings suggest central mechanisms complex stimulus integration rather peripheral dysfunctions probably determine somatosensory alterations asd
background aims providing preabortion contraceptive counseling method contraception may reduce incidence repeat abortions study aimed compare acceptance continuation rates intrauterine devices iuds combined oral contraceptives cocs condom use abortion women received preabortion contraceptive counseling methods women seeking first trimester abortion prospectively received preabortion contraceptive counseling choice method contraception based counseling related prior methods birth control outcomes included continuation postabortion contraceptive use repeat abortions month follow period results four hundred fifty five women iud group coc group condom group completed month follow abortions sixth month follow patients continued using iud coc condoms contraception respectively higher age married parity previous abortion factors associated frequent selection iud higher education level associated frequent selection coc condoms conclusion continued use cocs abortion low even preabortion contraceptive counseling iud offers reliable birth control lower discontinuation rate cocs condoms karger basel
goal research study effect substitution wheat starch potato starch performance health digestion growing rabbits three experimental diets formulated respectively similar starch contents dry matter basis proteins fibre three diets administered three groups rabbits weaning days slaughter days growth health measurements made another rabbits per diet rabbits age reared similar conditions slaughtered weeks age digesta collected analyse caecal microbial activity volatile fatty acids vfa levels fibrolytic activity starch concentration ileal digesta ages whole tract digestibility coefficients measured rabbits treatment rabbits feed intake days age days increased whole growth period days weight gain similar among diets day whereas feed intake feed conversion increased respectively diet mortality morbidity affected diets starch concentration ileal contents increased addition diet diets respectively starch digestibility percentage units higher diet diet bacterial cellulolytic activity caecum tended higher diet total vfa caecal concentration increased week old rabbits compared mmol protein digestibility ileal starch concentration decreased age weeks hemicelluloses digestibility increased weeks age rabbits showed higher vfa pool mol proportion butyrate lower proportion acetate ammonia level mmol ratio weeks age intake potato starch effect performance caecal microbial activity digestive health growing rabbits
aims proven strategies enhance physical activity cardiometabolic profiles patients type diabetes hypertension examined effects physician delivered step count prescriptions monitoring methods participants randomized active arm provided pedometers recorded step counts year period physicians reviewed records provided written step count prescription clinic visit overall goal steps day increase year individualized rate increase control arm participants advised engage physical activity min day evaluated effects step counts carotid femoral pulse wave velocity cfpwv primary cardiometabolic indicators including haemoglobin diabetes henceforth abbreviated homeostasis model assessment insulin resistance homa participants receiving insulin therapy results total completed final evaluations mean age years participants type diabetes hypertension net increase steps day active control arm participants changes cfpwv inconclusive active control arm participants type diabetes experienced decrease homa also declined active arm control arm assessed participants treated insulin conclusions simple physician delivered step count prescription strategy incorporated routine clinical practice led net increase step counts however steps day targeted increment conclusive effects cfpwv observed improvements insulin sensitivity future studies evaluate amplified intervention increase impact
present study investigated role nucleotide oligomerization domain like receptor family pyrin domain containing nlrp rheumatoid arthritis explored underlying mechanism found mrna protein levels nlrp attenuated synovial tissues fibroblast like synoviocytes fls patients compared patients osteoarthritis also observed pro inflammatory cytokine production decreased nuclear factor kappa activation inhibited nlrp overexpressing fls furthermore found nlrp overexpression promotes transforming growth factor activated kinase binding protein lysosome dependent degradation provide evidence showing nlrp plays role providing docking site facilitate interaction transforming growth factor activated kinase binding protein tripartite motif fls
objective determine pharmacy availability ulipristal acetate upa compare availability levonorgestrel containing emergency contraceptive pills lng ecps methods conducted observational population based study utilizing telephone based secret shopper methodology researchers called unique retail pharmacies hawaii december june representing patients physicians results pharmacies upa immediately available though reported ability order upa contrast reported immediate availability lng ecps significant difference availability reported patients physicians conclusions availability upa limited significantly lower compared lng ecps study period overlap change distributor upa likely capturing disruption supply chain elsevier inc rights reserved
objectivesto develop version montreal cognitive assessment moca administered severely hearing impaired moca assess performance two groups cognitively intact adults age study typetest development followed prospective subject recruitment methodsthe moca converted timed powerpoint microsoft corp redmond presentation verbal instructions converted visual instructions two groups subjects age recruited subjects passed screening questionnaires eliminate undiagnosed mild cognitive impairment first group normal hearing group second group severely hearing impaired group group received either moca moca test six months later subjects administered test moca moca received previously determine equivalency group received moca determine test retest reliability resultsone hundred three subjects recruited group score moca versus moca significant test retest coefficient conclusionthe moca easy administer reliable screening cognitive impairment severely hearing impaired conversion factor required prospectively tested cohort cognitively intact subjects level evidenceb laryngoscope
narcissists really like narcissists although research suggests answer yes current study demonstrates answer question simple study participants completed survey responded measure trait narcissism randomly assigned rate likability people described either narcissistic traits abstract trait description condition behavioral manifestations traits concrete behavior description condition results showed narcissists non narcissists rated narcissistic others significantly positively abstract trait description condition whereas effect non significant slightly reversed concrete behavior description condition interestingly interaction effect modified contextual salience one non narcissistic identity sum present research presents case narcissistic hypocrisy narcissists claim mote forgiving narcissistic traits follow claim led confront manifestations traits finding adds growing body work examining narcissists attitudes toward narcissism elsevier ltd rights reserved
antiplatelet anticoagulant drugs antithrombotics predispose acute chronic subdural hematomas patients drugs higher likelihood presenting larger hematomas severe neurologic deficits standard neurosurgical neurocritical care subdural hematomas involves reversal antithrombosis preoperatively whereas reversing antiplatelet drugs less clear article highlights spectrum antithrombotic agents common use mechanisms action strategies reversal
aim study evaluate changes foot shape women years undergoing breast amputation evaluation foot shape performed using non invasive device computer analysis plantar surface foot obtained results compared feet healthy breast side amputated breast side women aged years breast amputation enrolled case control study weight bearing lower extremity amputated breast side compared healthy breast side showed statistically significant differences patients put weight onto healthy breast side statistically significant difference found regard foot length well beta gamma angles highly statistically significant differences noted respect foot width alpha angle sztriter godunov index higher values observed healthy breast side highly statistically significant differences also noted comparing clark angles higher values observed operated breast side differences foot shape healthy breast side amputated breast side constitute long term negative consequence mastectomy caused unbalanced weight put feet healthy breast side compared amputated breast side
childbirth major life event women fear childbirth goes beyond trepidation towards full blown anxiety panic known fear childbirth foc tokophobia present study authors investigated compared intrapersonal interpersonal factors might associated foc among women previously gave birth parous women cross sectional survey conducted among women parous women women never given birth participants completed self report measures using online survey system questionnaires assessed intrapersonal factors including attitudes toward pregnancy birth body image self esteem life satisfaction well interpersonal factors namely relationship satisfaction multiple regression analyses revealed among parous women age attitudes toward pregnancy birth especially relate body image delivery significantly associated foc among women never given birth attitudes toward pregnancy birth especially relate body image importance pregnancy delivery preference caesarean section significantly associated foc groups satisfaction spousal relationship found associated foc results indicate regarding foc intra personal factors dominant inter personal factors assessing medico psychological fear cognitive aspects also addressed
report longitudinal stability personality traits across average years hawaii personality health cohort relating childhood teacher assessments personality adult self observer reports stabilities based self ratings adulthood compared measured structured interview five factor model siffm trull widiger trait ratings completed interviewers although convergence self reports observer ratings modest childhood traits demonstrated similar levels stability across methods adulthood extraversion conscientiousness generally showed higher stabilities whereas neuroticism showed none agreeableness intellect openness stability highest assessed observer ratings findings discussed terms differences trait evaluativeness observability across measurement methods elsevier inc rights reserved
recent advances development implicit constitutive relations describe response solids fluids greatly increased repertoire modeler ability describe natural phenomena faithfully hitherto possible would exaggeration claim constitutive relations potential lead breakthroughs mechanics provide promising novel means study two important ill understood problems mechanics fracturing solids turbulence fluids addition providing means describe plethora phenomena eluded explanation biomechanics response colloids mixtures etc article describe recent developments within context fluid solid mechanics
reinfections hepatitis virus described subgroups ongoing risk behaviour particular people infect drugs pwid men sex men msm article martinello colleagues describe reinfection incidence per person years mainly hiv infected msm also injecting drug users specific risk behavious counselling mandatory setting
behaviors keyhole weld pool dynamically coupled controlled pulse plasma arc welding used indicate weld quality vision system improved detect geometries keyhole weld pool backside simultaneously whole controlled pulse keyholing period one single ccd camera without auxiliary illumination assistance appropriate optical filter system unchanged aperture exposure time camera also adopted used different current period image processing method proposed extract keyhole boundary open keyhole status weld pool boundary whole welding process influences current waveform parameters welding process studied discussed found dimensions weld pool backside determined heat input plasma arc keyhole duration keyhole moves forward welding process weld pool maximum width backside located behind keyhole center
alcoholism hypothesized caused highly heterogeneous genetic load since many reports used bio psycho social approach subtype alcoholism however subtypes genetically validated reviewed compared major single gene multiple gene gene gene interaction studies alcoholism published past quarter century including many recent studies made contributions subtyping alcoholism four subtypes alcoholism reported pure alcoholism anxiety depression alcoholism antisocial alcoholism mixed alcoholism important studies focused three genes drd maoa aldh therefore review focuses three genes elsevier inc rights reserved
new major version european severe accident integral code astec developed irsn grs support delivered november astec worldwide community main modelling features version summarised paper particular vessel coupling technique reactor coolant system thermal hydraulics module core degradation module strongly engineered remove well known weaknesses former series version also includes new core degradation models specifically addressing bwr phwr reactor types well several physical modelling improvements notably reflooding severely damaged cores zircaloy oxidation air atmosphere corium coolability corium concrete interaction source term evaluation moreover version constitutes back bone cesam project final objective improve astec use severe accident management analysis gen iii nuclear power plants presently operation foreseen near future europe part european project irsn efforts continuously improve code numerical robustness computing performances plant scale well users tools intensified besides astec continue capitalising whole knowledge severe accidents phenomenology progressively keeping physical models state art regular feed back interpretation current future experimental programs performed international frame elsevier ltd rights reserved
microblogging platforms twitter serve important efficient channel sharing information prevalence geo position enabled devices rapidly growing amount microblogs associated geo tags consequently real time analysis geo tagged microblog stream attracted great attentions paper advocate significance keyword occurrence geo tagged microblogs analysis overlooked existing studies occurrence keywords necessary resolve ambiguity event analysis especially different events overlapping descriptions given geo tagged microblog stream formally define problem identifying local top maximal frequent keyword occurrence patterns geo tagged microblog stream namely lfp lkfp query given query region lfp query aims retrieve local maximal keyword patterns frequency exceeding given threshold lkfp query aims identify maximal keyword patterns highest local frequency case users threshold mind handle high volume microblog stream meet requirement large number queries issued develop novel data structures maintain data stream propose efficient algorithms process lfp lkfp queries theoretical underpinnings extensive empirical study real dataset confirms effectiveness efficiency approaches
extensive body research demonstrated patients occurring posttraumatic stress disorder ptsd substance use disorder sud diagnosis high risk wide range negative clinical outcomes including treatment noncompletion however studies date explored effect ptsd sud diagnosis residential sud treatment completion well potential moderators effect consequently goal study examine interactive effect ptsd diagnosis distress tolerance gender residential sud treatment retention participants substance dependent patients consecutively admitted residential sud treatment facility participants administered diagnostic interviews completed laboratory based measure followed throughout course treatment although significant main effects found results reveal significant ptsd gender interaction post hoc analyses indicated among men current diagnosis ptsd low completed significantly lower proportion residential sud treatment compared groups implications study findings identifying ways improve residential sud treatment retention among patients ptsd sud diagnosis discussed
paper presents simple linear control based force feedback gripper scorbot robotic arm scorbot degree freedom dof dexterous robotic arm rigid fingered parallel configuration gripper flexi force force sensitive resistor fsr attached one claws gripper interfaced notebook computer using arduino uno microcontroller force sensor aids robotic arm three different ways one senses object successfully grasped second determine coefficient friction object third prevent damage object grasped gripper along force sensor calibrated prior grasping objects calibration samples object manipulated used establish extents gripper basis grasping force following calibration pattern gripper able grasp objects approximately coefficient friction importantly ensures object grasped damaged applying sufficient amount force based object weight experimental analyses proposed work shown interesting results control scorbot robotic arm force sensor grasping masses strictly conforming safety margin object authors published elsevier open access article license http creativecommons org licenses
background aimsthe baveno guidelines recommend performing upper gastrointestinal endoscopy patients compensated cirrhosis liver stiffness low prevalence varices risk bleeding population aim synthesize available evidence usefulness combined use liver stiffness platelet count identify patients without oesophageal varices methodsmeta analysis trials evaluating usefulness given cut liver stiffness platelet count rule presence oesophageal varices resultsfifteen studies included studies excepting five used baveno criteria compared patients either high liver stiffness low platelet count low liver stiffness normal platelet count lower risk varices risk bleeding low heterogeneity studies also lower risk varices moderate heterogeneity studies patients low liver stiffness normal platelet count pooled estimate rates varices risk bleeding low heterogeneity studies conclusionspatients low liver stiffness normal platelet count lower risk varices either high liver stiffness low platelet count varices risk bleeding found patients liver stiffness kpa platelet count normal
redundant basis multipliers galois field gained huge popularity elliptic curve cryptography ecc mainly negligible hardware cost squaring andmodular reduction paper proposed novel recursive decomposition algorithm multiplication obtain high throughput digit serial implementation efficient projection signal flow graph sfg proposed algorithm highly regular processor space flow graph psfg derived identifying suitable cut sets modified psfg suitably performed efficient feed forward cut set retiming derive three novel multipliers involve significantly less time complexity existing ones also require less area less power consumption compared others theoretical analysis synthesis results confirm efficiency proposed multipliers existing ones synthesis results field programmable gate array fpga application specific integrated circuit asic realization proposed designs competing existing designs compared shown proposed high throughput structures best among corresponding designs fpga asic implementation shown proposed designs achieve savings area delay power product adpp fpga asic implementation best existing designs respectively
world health organization reputation became irrefutably damaged ebola outbreak general consensus global health community fell short leadership responsibilities commentary offers brief synopsis role outbreak suggests disease outbreak demonstrates tension exists organization normative operational roles health crises offer normative leadership ebola outbreak per constitution provide effective operational response yet mandate division normative operational highlighted discrepancy global community expects health emergency able financial organizational constraints finally commentary considers introduction health emergency programme suggests may suffer structural concerns need addressed continue role global health community expects play normative operational leader global disease control article part themed issue west african ebola epidemic data decision making disease control
hyperlipidemia common general population incidence increased recent years evaluation patient presenting lipid disorders essential obtain definite diagnosis prevent complications apply appropriate treatment isolated elevation triglyceride levels may caused primary disorder lipid metabolism like familial hypertriglyceridemia may also arise secondary number conditions like diabetes mellitus alcohol intake hypothyroidism drugs infections nephrotic syndrome herein describe case secondary hypertriglyceridemia leading nonalcoholic steatohepatitis nash young female attributed multiple myeloma significant reduction triglyceride levels starting anti myeloma therapy established relation first case light chain myeloma causing severe secondary hypertriglyceridemia
green building gaining increased acceptance construction industry viable solution meeting growing demand environmentally friendly healthy buildings however uptake technologies apparent paper aims examine criticality various barriers preventing wider adoption technologies results statistical analyses questionnaire survey responses experts around world presented results validated criticality barriers used survey respondents different countries diverse backgrounds displayed broad consensus criticality levels barriers resistance stakeholders change higher cost identified critical barriers implementing technologies generally various groups respondents shared similar views number barriers affecting industry however respondents years experience perceived fewer barriers factor analysis showed barriers technologies adoption could grouped five main interrelated components suggest need holistic integrated strategies overcome barriers findings paper could help policy makers identify specific problems technologies adoption develop suitable strategies wider uptake perspective international experts study contributes body knowledge barriers
maintenance repair highway network system major expenses state budget reason various concerned organizations pointing need developing intelligent efficient pavement performance model prioritize pavement maintenance rehabilitation works models forecast remaining pavement service life pavement rehabilitation needs help formulation pavement maintenance strengthening programmes reduce road agency road user costs flexible pavement performance deterioration models involve complex interaction vehicles environment structure surface pavement performance models relating pavement distress conditions like cracking raveling potholing roughness analyzed developed various researchers models found applicable particular set traffic environment conditions thus highlighting need model work varied conditions satisfactorily paper presents detailed review various pavement performance models examine role factors related pavement materials environmental conditions type traffic volume traffic identify limitations gaps present knowledge models
elevated temperature performances alloy hot extrusion rods two stage homogenization intensive deformation studied measuring elevated temperature enduring strength creep ultimate strength fracture morphology selected samples testing different elevated temperatures observed scanning electron microscopy sem results indicate test temperature increases elevated temperature enduring strength alloy decreases gradually comparison degrees degrees notch enduring strength drops mpa smooth enduring strength drops mpa enduring strength sensitive notch notch sensitivity ratio nsr coefficient range degrees degrees creep test results show test temperature increases degrees degrees creep ultimate strength alloy rods drops gradually mpa
novel envelope following method presented fast accurate transient simulation microwave circuits almost periodic responses targeted circuits contain high frequency components whose amplitudes vary slowly proposed high order method based stable high order obreshkov formula obf use high order formula allows accurate fast analysis keeping accuracy conventional low order integration methods validated presented numerical example
recent years strong evidence emerged suggesting insufficient duration quality timing sleep associated cardiovascular disease cvd various mechanisms association proposed associations may related endophenotypic features sleep homeostat circadian oscillator may state like effects environment review recent literature sleep circadian rhythms cvd specific emphasis differences racial ethnic groups discuss reported differences mainly individuals european african descent parameters related sleep architecture duration quality circadian rhythms period length phase shifting review racial ethnic differences cardiovascular disease risk factors develop hypothesis racial ethnic health disparities may greater smaller degree relate differences parameters related sleep circadian rhythms humans left africa years ago genetic differences different races ethnicities acquired genetic differences proposed possible predictor cvd disparities concomitant differences culture lifestyle different groups may equally explain cvd disparities discuss evidence genetic environmental causes differences sleep circadian rhythms usefulness health intervention targets elsevier ltd rights reserved
objective establish three dimensional finite element model ankylosing spondylitis kyphosis digital platform studies methods year old man kyphosis underwent computed tomography transverse scanning sacrococcyx images imported mimics software establish model posterior spine imported studio geomagic software posterior spine convex geometry established geometric model subsequent optimization image processing unigraphics produced spinal kyphosis surface model modeled calcification ligaments partial resection useless sacral bone added model imported ansys analysis software ligaments added parameters set generate model results conclusion model successfully established providing reliable digital platform subsequent biomechanical analysis
intra abdominal infection iai hepatectomy important morbidity identification risk factors could avoided perioperative period may reduce prevalence iai hepatectomy hepatocelluar carcinoma hcc january december patients hcc underwent curative liver resection evaluated retrospectively long term outcomes compared iai patients non iai patients hepatectomy preoperative intraoperative tumor related factors could independent factors postoperative iai identified patients hcc patients iai hepatectomy median survival survival patients postoperative iai shorter non iai patients pminutes iai hepatectomy affects outcome adversely preoperative weight loss liver cirrhosis operative time minutes independent predictors postoperative iai
objective examine impact sleep duration lung function asthma symptoms adolescents methods ten adolescents asthma female caucasian mean age years range completed week randomized cross sleep manipulation protocol following week self selected sleep duration adolescents randomized five night deficient sleep opportunity bed healthy sleep opportunity bed obtained systematically changing bedtimes wake time remained consistent across weeks including weekends daily reports sleep patterns asthma symptoms actigraphy daily peak expiratory flow rates pefr well weekly spirometry exhaled nitric oxide collected results participants averaged less sleep per night short sleep condition versus long sleep condition decrease overnight pefr reported asthma symptoms interfering activities past short sleep condition long sleep condition significant differences experimental weeks found weekly spirometry exhaled nitric oxide conclusions pilot study demonstrated feasibility cross sleep manipulation protocol adolescents asthma since overnight decrease pefr marker nocturnal asthma associated severity daytime airflow limitation early stage results suggest shortened sleep duration may exacerbate adolescent asthma associated functional impairments wiley periodicals inc
paper new circuit practical emulation floating memristor presented circuit simple flexible built around current feedback operational amplifier avoids use analog digital digital analog converters analog multiplier circuit simpler available similar circuits application proposed floating memristor emulator designing converter confirms functionality proposed circuit experimental results included
rapid proliferation rfid technologies rfid introduced applications inventory sampling inspection conventionally rfid systems reader usually identifies rfid tags interrogation region maximum power however applications may need identify tags specified area usually smaller reader default interrogation region example could identifying tags box ignoring tags box paper respectively present two solutions identify tags specified area principle solutions compared picture taking process auto focus camera firstly focuses target automatically takes picture similarly solutions first focus specified area shoot tags design two solutions based extensive empirical study rfid tags realistic experiment results show solutions reduce execution time percent compared baseline solution identifies tags maximum power furthermore improve proposed solutions make work well complex environments
understanding beliefs values preferences patients tenet contemporary health sciences application motivated analysis multiple partially ordered set poset responses inventory layman beliefs diabetes partially ordered set arises two features data first response options contain know option second two consecutive occasions measurement predicted common sense model illness beliefs diabetes necessarily stable across two measurement occasions instead analyzing two occasions separately studied joint responses across occasions poset response analytic methods exist data structures ordered nominal categories poset responses routinely collapsed analyzed either rank ordered nominal data leading loss nuanced information might present within poset categories paper developed general class item response models analyzing poset data collected common sense model diabetes inventory inferential object interest latent trait indicates congruence belief biomedical model apply item response model poset diabetes inventory proved simple coding algorithm circumvents requirement writing new codes standard irt software could directly used purpose item estimation individual scoring simulation experiments used examine parameter recovery proposed poset model
although total hip replacement thr proven effective effect thr employment ankylosing spondylitis chinese population still unknown aimed demonstrate whether patients returned work following thr factors associated work ability thr performed retrospective study including total number patients undergoing thr presurgery postsurgery data including disease state work status type job time resuming work collected factors associated early return work assessed ordinal regression eighty seven patients employed within year thr returned work surgery among resumed work months postoperation respectively multivariate ordinal regression showed patients unilateral thr younger age lower basfi score employed presurgery low moderate physical demand likely resume work earlier individuals working presurgery returned work thr young patients hip involvement thr effective treatment improving maintaining work ability
background vestibular migraine meniere disease two types episodic vertigo syndromes already observed greek chinese antiquity descriptions first appeared work classical greek physician aretaeus cappadocia lived century huangdi neijing seminal medical source chinese medical classics written century century aim aim paper search aretaeus book causis signis acutorum chronicorum morborum huangdi neijing descriptions vertigo occurring headache ear symptoms resemble current classifications vestibular migraine meniere disease results aretaeus describes syndrome combining headache vertigo visual disturbance oculomotor phenomena nausea resembles symptoms vestibular migraine chinese book huangdi neijing yellow thearch mentions occurrence episodic dizziness ringing noise ears recalls attack meniere disease conclusions descriptions two conditions greek chinese antiquity similar vertigo syndromes currently classified vestibular migraine meniere disease clinical practice may difficult clearly differentiate may also occur
objective introduction health information technology systems electronic health records particular changing nature clinicians interact patients lack knowledge remains best integrate systems exam room purpose systematic review distill best behavioral communication practices recommended literature clinicians interacting patients presence computerized systems clinical encounter weigh evidence recommendation rank evidence based recommendations electronic health record communication training initiatives clinicians methods conducted literature search databases resulting articles included analysis extracted information study setting research design sample findings implications recommendations distilled based consistent support behavioral communication practices across studies results eight behavioral communication practices received strong support evidence literature included specific aspects using computerized systems facilitate conversation transparency exam room spatial organization exam room maintaining nonverbal communication specific techniques integrate computerized system visit engage patient four practices although patient centered received insufficient evidence date discussion conclusion developed evidence base best practices clinicians maintain patientcentered communications presence computerized systems exam room work includes development empirical evaluation evidence based guidelines better integrate computerized systems clinical care
many kinds orbit space robot tasks capturing free floating target using space robot attracts attention researchers however existing researches dynamics control space robot concern planar problem effect flexible panel capturing dynamics system considered paper spatial dynamics control dof space robot flexible panels investigated spatial impact problem considered dynamic model system established single direction recursive construction method jourdain velocity variation principle hertz contact impact theory method computer graphics used establish impact model computed torque control method used design active controller suppress spacecraft drift caused impact numerical simulation results show established dynamic model effective describing dynamics behavior space robot flexible panels big influence impact dynamic characteristics designed controller may effectively control spacecraft drift capture process iaa published elsevier ltd rights reserved
advances vehicular technology resulted controls incorporated cabin designs present system determine vehicle occupant interacting control center console activated enabling full use dual view touchscreens removal duplicate controls proposed method relies background subtraction algorithm incorporating information superpixel segmentation stage manifold generated via diffusion maps process handles large variation hand shapes along determining part hand interacts controls given gesture demonstrate superior results compared approaches challenging dataset
motivated terms mathematical concepts theory electrical networks klein ivanciuc introduced studied new graph theoretic cyclicity index global cyclicity index klein lvanciuc paper utilizing techniques graph theory electrical network theory real analysis obtain results new cyclicity measure including strictly monotone increasing property lower upper bounds nordhaus gaddum type results particular establish relationship global cyclicity index cyclomatic number connected graph vertices edges elsevier rights reserved
mobile hoc network network mobile nodes communicate help wireless links mobile nodes move randomly network without centralized management system manet wireless network security major concern different type attacks manipulate data info transmitted source node destination node network paper presentsthe literature review dsr routing protocol previously proposed approaches plays major role enhancing performance dsr routing protocol paper introduces hashing technique enhance security dsr routing protocol mobile hoc network
background skin fibrosis clinically serious pathological process secondary lymphedema sle detection latent incipient skin fibrosis including early tissue changes using sensitive diagnostic equipment essential skinfibrometer used skin care however ability assess skin fibrosis patients sle lower limb explored methods results study female patients secondary unilateral lower limb healthy female volunteers enrolled skin stiffness values affected healthy limbs measured using skinfibrometer skin samples assayed masson staining circumference interstitial fluid limbs also measured analyzed increasing skin stiffness increasing severity sle lower limb skin stiffness significantly positively correlated stage lower limb sle conclusions results demonstrate skinfibrometer sensitive accurate detecting skin fibrosis edematous limb therefore new instrument promising prospect diagnosis assessment skin fibrosis patients lower limb sle
always challenging reconstruct magnetic resonance images limited set space data due ill posed nature effective way compensate data incompleteness use sparsity based regularisation recent work image processing suggests exploiting structured sparsity may lead improved results study idea explored combination additional support prior images analysis context put differently authors propose highly effective regulariser constraining group sparsity analysis coefficients within pre estimated cosupport two stage iterative algorithm developed proceeds alternatively calling two key components image reconstruction cosupport detection feasibility proposed method demonstrated individual multiple weighted images simulation results show considerable improvement method compared methods using structured sparsity support knowledge synthesis context related reconstruction methods
current philosophy mind two main approaches question personal identity first one claims personal identity based memory several decades known psychological approach problem second one called animalistic approach considers personal identity biological property human beings specific feature bodily continuity experiments creating false memories mice brains recently conducted mit seem shed new light question personal identity taking account fact mouse brain morphologically quite similar brain purpose article clarify question whether mentioned experiments support one approaches psychological animalistic using conceptual instrumentarium contemporary analytic philosophy cognitive phenomenology author differentiates strong weak false memories argues consider conducted experiments supporting animalistic approach
objective benign external hydrocephalus beh enlargement subarachnoid spaces sass seen young children controversial whether children beh predisposed developing subdural hemorrhage sdh without trauma issue clinically relevant finding unexplained sdh raises concerns child abuse often prompts child protection law enforcement investigations methods retrospective study included children months age underwent head scanning accidental fall less feet head scans reviewed cranial findings documented sas measured qualitatively evaluated enlarged sas defined extraaxial space eas greater scans clinical measurements head circumference noted head circumference percentile calculated relationship enlarged sas percentile enlarged sas intracranial hemorrhage ich investigated using bivariate analysis results children included sample eass greater mean patient age months median months thirty four patients ichs including subarachnoid subpial subdural epidural unspecified extraaxial hemorrhage enlarged sas positively associated subarachnoid subpial hemorrhage association enlarged sass either sdh epidural hemorrhage larger sas positively associated larger percentile however percentile independently associated ich conclusions enlarged sas associated sdh associated ichs authors findings support theory beh predisposes children sdh minor accidental trauma
present study examined big five personality ratings target individuals differ function power relation target judge targets employees leadership duties two large organizations targets subordinates peers superiors constituted groups judges targets judges also provided self reports personality subordinate judges showed higher consensus higher self agreement peer superior judges furthermore targets judged extraverted emotionally stable less agreeable less open experience subordinates superiors results suggest observer consensus self agreement assumed similarity varies function real life power effects power mean trait scores mostly congruent previously observed effects power behaviour stereotypes copyright john wiley sons ltd
data limited regarding use direct acting antivirals treatment hepatitis infection post lung transplant especially donor derived infection present case lung transplant recipient donor derived hepatitis successfully treated week regimen simeprevir sofosbuvir case reiterates importance screening recipients increased risk donor organs disease transmission value early therapy
objective advanced statistical tools created opportunity systematically examine effect early trajectories predictors therapeutic change early alliance development patterns outcome date however methods used almost exclusively examine effect development early symptoms later ones development patterns alliance early treatment association treatment outcome received much theoretical attention systematic examinations conducted far method integrated exploratory cluster analysis accumulated theoretical empirical knowledge patterns alliance development identify distinct patterns early alliance development across sessions treatment sample patients receiving psychotherapy results three patterns early alliance development identified early gradual strengthening early repaired rupture early unrepaired rupture gradual strengthening repaired rupture patterns early treatment predicted alliance strengthening later treatment whereas unrepaired rupture pattern early treatment predicted alliance stability later treatment effect early alliance development patterns treatment outcome moderated pretreatment interpersonal problems patients better interpersonal functioning intake gradual strengthening repaired rupture patterns showed better outcomes whereas poorer interpersonal functioning intake early unrepaired rupture pattern showed better outcomes conclusions findings suggest early alliance development patterns affect treatment process outcome
asians highest rates end stage renal disease limited information risk factors chronic kidney disease ckd asian general population risk score incident ckd general population developed framingham heart study fhs offspring cohort score validated caucasians african americans tested asians aimed assess importance fhs risk factors performance fhs risk score predicting incident ckd years thai community based population prospective study evaluate risk factors performance fhs risk score comprising age diabetes hypertension proteinuria gfr predicting incident ckd years employees electric generating authority thailand excluding subjects ckd baseline developed incident ckd defined mdrd equation ckd epi equation diabetes hypertension baseline gfr strong predictors incident ckd proteinuria agreement observed rates rates predicted fhs risk score high mdrd chi ckd epi chi discrimination incident ckd modest auroc mdrd ckd epi although diabetes hypertension baseline gfr important risk factors fhs risk score might sufficiently accurate estimating incident ckd asian general population
paper extend several well known document listing problems case documents contain substring approximately matches query pattern study scenario query string contain wildcard symbol matches alphabet symbol documents match query pattern one wildcard must enumerated describe linear space data structure reports documents containing substring pin vertical bar vertical bar sigma root logloglog docc time sigma alphabet size docc number listed documents also describe succinct solution problem well solution extension problem furthermore approach enables obtain sigma space data structure enumerates documents containing pattern pattern special case differ one symbol published elsevier
chondrogenesis mesenchymal stem cells mscs known regulated number environmental factors including local oxygen levels hypothesis study response mscs hypoxia dependent physical chemical characteristics substrate used objective study explore different modifications polycaprolactone pcl scaffolds influenced response mscs hypoxia pcl pcl hyaluronic acid pcl bioglass scaffolds seeded mscs derived bone marrow cultured days normoxic low oxygen conditions resulting biochemical properties msc laden construct assessed low oxygen tension positive effect cell proliferation macromolecules biosynthesis furthermore hypoxia enhanced distribution collagen glycosaminoglycans gags deposition scaffold hand mscs displayed certain material dependent responses hypoxia low oxygen tension positive effect cell proliferation scaffolds positive effect gags synthesis pcl scaffolds conclusion hypoxia increased cell viability expression chondrogenic markers cell response modulated type scaffold used wiley periodicals inc
overall objectives research work icollaborate mse materials science engineering project measure improvements student learning outcomes student engagement successful course completion possible structure basic materials engineering courses transformed primarily deductive practice information communication technology ict enabled inductive teaching learning environment specific innovations proposed project development mse education applications ipod touch facilitate support collaborative learning opportunities targeting specific student learning objectives known challenging many students basic mse courses studying whether combination specific learning objective targets completed collaborative groups supported conceptually contained data visuals audio information ipod touch lead specific improvements learning outcomes students purpose work progress paper describe initial suite ipod applications created challenges faced development observable differences collaborative experiences students without devices work supported national science foundation ccli grant
environmental hormonal factors implicated dysimmunity multiple sclerosis investigated whether bisphenol prominent contaminant endocrine disrupting capabilities altered susceptibility inflammatory model multiple sclerosis found gestational adult exposure bisphenol increased development experimental autoimmune encephalomyelitis adulthood male female mice suboptimal disease inducing immunization used gestational bisphenol male mice primed macrophages adulthood raised granulocyte colony stimulating factor neutrophil counts activity postsuboptimal immunization neutralizing granulocytecolony stimulating factor blocked susceptibility disease bisphenol mice early life exposure bisphenol may represent environmental consideration multiple sclerosis
aims objectives describe nursing activities primary care patients affected physical chronic disease common mental disorders background patients primary care affected physical chronic disease common mental disorders anxiety depression require care follow based physical mental health condition primary care nurses increasingly expected contribute care follow growing clientele however little known actual activities carried primary care nurses providing service province quebec canada methods qualitative descriptive study conducted data obtained semistructured individual interviews nurses practising among patients physical chronic disease seven family medicine groups quebec canada results participants described five activity domains assessment physical mental health condition care planning interprofessional collaboration therapeutic relationship health promotion conclusion full potential primary care nurses always exploited activities could improved evidence including nurses collaborative care patients affected physical chronic disease common mental disorders shown fully implemented family medicine groups future research emphasise collaboration among mental health professionals primary care nurses family physicians care patients physical chronic disease common mental disorders relevance clinical practice primary care nurses would benefit gaining knowledge common mental disorders identifying resources need contribute managing interdisciplinary team
introduction idiopathic pulmonary fibrosis ipf one common forms interstitial lung disease median survival time two five years patients ipf experience chronic breathlessness closely linked poor perceived quality life significant restriction daily activities therefore effective management distressing symptom major goal patient care areas covered report summarizes physiology ipf rest exercise outlines current concepts mechanisms breathlessness provides physiological rationale optimal management individual patients also examines evidence efficacy number therapeutic interventions currently disposal management breathlessness ipf aim reduce respiratory neural drive reduce worsening mechanical load alter central perception expert commentary current evidence supporting general measures relieving chronic breathlessness weak hence carefully designed prospective studies required
backgroundhydrogen sulfide serves mammalian cell derived gaseous neurotransmitter intestines exposed second source gas sulfate reducing bacteria srb bismuth subsalicylate binds rendering insoluble aim study test hypothesis srb may slow intestinal transit bismuth reversible fashion methodseighty mice randomized five groups consisting live srb killed srb srb bismuth bismuth saline desulfovibrio vulgaris common strain srb administered gavage dose cells along rhodamine fluorescent dye intestinal transit measured minutes gavage euthanizing animals removing small intestine pyloric sphincter ileocecal valve visualizing distribution rhodamine across intestine using imaging system ivis perkin elmer intestinal transit compared using geometric center minimal movement maximal movement concentration also measured small intestinal luminal content allowed generate gas key resultsthe live srb group slower intestinal transit represented geometric center score compared saline killed srb srb bismuth bismuth correspondingly live srb group highest luminal concentration ppb compared ppb srb bismuth group conclusions inferenceslive srb slow intestinal transit bismuth reversible fashion mice results demonstrate intestinal transit slowed srb effect could abolished binding bismuth
despite recent advent various radiographic imaging techniques still difficult correctly distinguish pediatric osteolytic lesion occipital condyle makes complicated decide necessity adequate timing radical resection craniocervical fusions establish legitimate therapeutic strategy deep seated lesion surgical biopsy reasonable choice first line intervention choice surgical approach becomes important sufficient amount histological specimen must obtained confirm diagnosis ideally residual bony structures muscular structures preserved increase craniocervical instability report present experience case solitary langerhans cell histiocytosis lch involving occipital condyle successfully treated minimally invasive surgical biopsy far lateral condylar approach supported preoperative computer graphic simulation year old girl presented neck pain magnetic resonance imaging computed tomography revealed osteolytic lesion left occipital condyle surgery patient placed prone position skin incision made posterior auricular region sternocleidomastoid splenius capitis muscles dissected middle muscle bundle along direction muscle fiber navigation system approached occipital condyle space longissimus capitis muscle posterior belly digastric muscle lateral superior oblique muscle verifying muscle depth surgical field finally obtained sufficient surgical specimen biopsy craniocervical instability worsened chemotherapy performed twelve weeks chemotherapy neck pain gradually disappeared along torticollis showed remission lesion marked regeneration left occipital condyle within knowledge first reported case lch involving occipital condyle although rare case indicated lch alternative differential diagnosis osteolytic lesions craniocervical junction early bone regeneration sufficient cervical stability expected chemotherapy cases pediatric osteolytic lesions initially presented apparent cervical instability craniocervical fusion may possibly become unnecessary series treatments thus effort maximally preserve musculoskeletal structure made histological diagnosis finally confirmed
ensemble weather predictions introduced operation district heating systems create heat load forecast dynamic uncertainties provide new valuable tool time dependent risk assessment related security supply energy markets useful production planning online operation modern district heating system particular light low temperature operation integration renewable energy close interaction electricity markets paper simple autoregressive forecast model weather prediction input used showcase new concept study period performance comparable complex forecast models total uncertainty heat load forecast divided constant model uncertainty plus time dependent weather based uncertainty latter varies much factor depending ensemble spread consequence total forecast uncertainty varies significantly forecast model applied operation three heat exchanger stations applying optimized temperature control significantly lower supply temperatures compared current operation improving temperature control dynamic time dependent weather based uncertainties lower supply temperature reduce heat losses ground potential benefit using dynamic uncertainties larger systems relatively smaller pumping capacities elsevier ltd rights reserved
present study mainly investigates bubble behaviors agitated vessel computational fluid dynamics provides method exploring complex fluid flow agitated vessel stirred tank model transport equation interfacial area concentration force equilibrium equation bubbles multi forces created agitated vessel model considers breakage coalescence mechanism bubbles local gas holdup measured flber optical probe bubble size distributions calculated interfacial area concentration model simulations validated models show good agreement experiments simulation results area gas holdup value greater extends upper circulation region rotation speed increased rad rad however lower circulation gas holdup maintains low level due existence death zone simulations indicate bubble breakage mainly occurs impeller flow region coalescence occurs upper circulation region bubble behaviors lower circulation region bubble coalescence breakage determined flow fleld pattern vessel moreover flcult simulation process converge virtual mass force considered lack effective technology measure led researchers generally ignore force order analyze virtual mass force present study utilizes computer programming based virtual mass force formula obtain force results show positions close impeller tip center upper region virtual mass force value respectively value approximately zero bulk tank hence bubble two signi flcant stages acceleration process vessel
study represents continuation previously performed study sorensen use development online method determining iodine number porcine adipose tissue use near infrared spectroscopy original study fat tissue measured function depth skin thus represent spatial near infrared data measured across porcine carcass represents data pig data structures largely ignored original publication explored multivariate curve resolution massive amount near infrared data spectra unfolded true five way array carcass horizontal position vertical position depth spectral data points two way matrix sample spectra maintaining spatial data separate array multivariate curve resolution applied two component multivariate curve resolution model proved fit data nearly perfectly variance explained concentration highest component found fat second component found water surprisingly latter found vary strongly iodine value fat resulting multivariate curve resolution model folded back original spatial dimension produce maps showing distribution constituent concentrations adipose tissue
proliferation heterogeneous computing platforms presents parallel computing community new challenges one challenge entails evaluating efficacy parallel architectures identifying architectural innovations ultimately benefit applications address challenge need benchmarks capture execution patterns dwarfs motifs applications present future order guide future hardware design furthermore desire common programming model benchmarks facilitates code portability across wide variety different processors cpu apu gpu fpga dsp computing environments embedded mobile desktop server present latest release opendwarfs benchmark suite currently realizes berkeley dwarfs opencl vendor agnostic open standard computing language parallel computing using opendwarfs characterize diverse set modern fixed reconfigurable parallel platforms multi core cpus discrete integrated gpus intel xeon phi processor well fpga describe computation communication patterns exposed representative set dwarfs obtain relevant profiling data execution information draw conclusions highlight complex interplay dwarfs patterns underlying hardware architecture modern parallel platforms
incorporation fluorine atoms functional molecules wide interest synthetic organic chemistry well cognate disciplines particular medicinal chemistry strong desire positively influence physicochemical molecular properties drug compounds introducing fluorine biologically active molecules present targeted fluoro positioning key design principle converting weak matrix metalloproteinase mmp inhibitor potent highly selective selectivity factors mmp inhibitor excellent plasma microsomal stability binding herg channel herg human ether related gene
dysregulation hypothalamic pituitary adrenal hpa axis associated diverse adverse health outcomes making important therapeutic target measurement diurnal rhythm cortisol secretion provides window system present guidelines exist optimal use biomarker within randomised controlled trials rcts aim study describe ways salivary diurnal cortisol measured within rcts health behavioural interventions adults six electronic databases may systematically searched rcts used salivary diurnal cortisol outcome measure evaluate health behavioural interventions adults narrative synthesis undertaken findings relation salivary cortisol methodology outcomes studies fulfilled inclusion criteria included healthy participants included patients physical disease included patients psychiatric disease psychological therapies commonly evaluated substantial heterogeneity across studies relation saliva collection protocols reported cortisol parameters studies calculated rhythm parameter diurnal slope cortisol awakening response car patterns change cortisol parameters inconsistent within across studies low agreement clinical findings salivary diurnal cortisol measured inconsistently across rcts limiting interpretation findings within across studies indicates need validation work along consensus guidelines
recent studies indicate migraine associated increased risk cardiovascular diseases however links autonomic cardiovascular regulation arterial hypertension migraine still little explored study evaluated autonomic regulation migraine patients without hypertension studied patients migraine aged including without hypertension groups respectively control group consisted healthy volunteers matched age sex autonomic regulation circulation examined tilt table test deep breathing valsalva maneuver handgrip test cold stress induced vasoconstriction arterial baroreflex blood pressure variability measurements found migraine patients concomitant hypertension demonstrated reduced arterial baroreflex whereas parameters cardiac autonomic regulation unchanged contrast indicators vasomotor reactivity blood pressure response hand grip valsalva maneuver cold vasoconstriction enhanced migraine patients significant differences migraine patients without hypertension patients groups commonly family history cardiovascular disorders data revealed increased vasomotor reactivity migraine patients without concomitant hypertension associated family history cardiovascular diseases elsevier rights reserved
controlling nonlinear bistable mechanics crucial development advanced bistable devices ranging quantitative mass sensing smart material structures however large amount pre shaped bistable mechanisms one two specific bistable characteristics two switching forces stroke bistable index parameter fulfill special application requirements due complex coupling effects among different bistable mechanical properties really difficult modify one specific bistable character without affecting others modifying structure parameters bistable configuration boundary constraints fixed accurate mechanical analysis mems bistable mechanisms novel optimization based method designing specific bistable characteristic proposed modifying beam local segment geometry optimizing bistable index parameter two switching forces respectively accordingly five bistable compliant mechanisms reconstructed symmetrically asymmetrically achieving different bistable mechanics also sharp change nonlinear force displacement curve induced mode switching analyzed experimental study quasi cosine shaped beam reinforced local segments manufactured hot forming beryllium bronze sheet good agreement numerical simulation experimental results validates effectiveness optimization based bistability design method thus expanding potential application range compliant bistable mechanisms elsevier rights reserved
objectives although consensus sex hormones modulate memory incomplete understanding role remembering forgetting humans continuously update memory forgetting old date information encoding new relevant information updating processes studied list method directed forgetting methods list method directed forgetting task subjects study two lists items study list asked either forget remember list upcoming memory test free testosterone level quantified saliva samples directed forgetting saliva testosterone evaluated young men aged years results following forget cue recall list items reduced recall list items enhanced however recall list items associated free testosterone level following forget cue participants low testosterone levels showed higher recall list items participants high testosterone levels conclusion selective association testosterone level list recall consistent two mechanism accounts memory updating forgetting effect due impaired retrieval enhancement effect improved encoding basis view present results indicate low testosterone levels associated improved binding newly encoded memories context cue
new process oriented approach needed construction management lean construction emphasizes concept flow way understand production construction yet still accepted metric measurement flow quality hampered research practice proposed construction flow index cfi composite measure reflects quality production flow repetitive construction projects incorporates measures work continuity crews processing continuity locations production rate variation amounts work progress interference operation sequence logic expert knowledge acquired establish weights cfi parameters use tested evaluating planned actual production flows number projects project managers use cfi evaluate quality construction plans measure communicate production flow quality status trade crews enabling management improvement production flow cfi also valuable tool construction research cfi challenges traditional construction management measuring flow standard practice measures transformation earned value challenges lean construction practice using last planner system suggesting percent plan complete measure plan reliability insufficient
brownian motion adaptive drift attracted much attention prognostics first hitting time highly relevant remaining useful life prediction follows inverse gaussian distribution besides linear degradation modeling nonlinear drifted brownian motion developed model nonlinear degradation moreover first hitting time distribution nonlinear drifted brownian motion approximated time space transformation previous studies drift coefficient hidden state used state space modeling nonlinear drifted brownian motion besides drift coefficient parameters nonlinear function used nonlinear drifted brownian motion treated additional hidden states state space modeling make nonlinear drifted brownian motion flexible paper prognostic method based nonlinear drifted brownian motion multiple hidden states proposed applied predict remaining useful life rechargeable batteries sets rechargeable battery degradation samples analyzed validate effectiveness proposed prognostic method moreover comparisons standard particle filter based prognostic method spherical cubature particle filter based prognostic method two classic bayesian prognostic methods conducted highlight superiority proposed prognostic method results show proposed prognostic method lower average prediction errors particle filter based prognostic methods classic bayesian prognostic methods battery remaining useful life prediction elsevier ltd rights reserved
mechanism galvanised wire strand fracture suspension bridge main cables still subject fully understood often focus research studies current study presents findings third cable inspection performed forth road bridge scotland extensive test programme included metallographic wire examination tensile testing cyclic fatigue testing carried findings discussion possible mechanisms contributing wire failure provided results showed tensile strength reduction due extremely localised corrosion propagates perpendicular cracks within individual wires directly related general corrosion severity classification used industry required depth propagation cause fracture shown range low radius wire possible mechanisms crack initiation propagation considered include pitting corrosion hydrogen assisted cracking branched cracking corrosion fatigue elsevier ltd rights reserved
extensive application rainwater harvesting rwh projects inhibited challenge posed dry seasons case study mnyundo primary school tanzania performance rwh system evaluated using daily water balance model methodology based defined dry season parameters water days nwds rainwater usage ratio rur water level local water storages system operational methods involve users adopting either fixed constant demand variable demand demand varying respect available water storage tank throughout system utilization additionally cost installing rwh system achieve substantial reduction nwds zero calculated established existing system achieve zero nwds consideration operational methods however greater number tanks lower nwd variable demand operational method better rur achieved mitigating water shortages dry season school adopt rwh two buildings demand scenario demand respective water levels storage tanks yielding rur performance system improved monitoring water levels adhering demand guidelines useful strategies practitioners water supply
objectivesosteonecrosis jaw onj potentially severe adverse effect bisphosphonates although risk onj increases increasing duration treatment currently reliable estimates onj time onset tto objective study estimate tto associated risk factors treated patients subjects methodsretrospective analysis data secondary care centres seven countries relevant patients developed related onj resultsthe median tto years patients treated alendronate years treated zoledronate multivariable cox regression showed dentoalveolar surgery inversely associated use antiangiogenics directly associated tto patients cancer treated zoledronate conclusionsthe incidence onj increases duration therapy notable differences observed respect type potency route administration underlying disease data stratified type time years oral alendronate intravenous zoledronate therapy respectively required patients develop onj stratification disease time years therapy required patients osteoporosis cancer respectively develop onj findings significant implications design future clinical studies development risk reduction strategies aimed either assessing modulating risk onj associated
effectiveness emergency contraception usually estimated comparing number observed pregnancies expected pregnancies unprotected intercourse second generation selective progesterone receptors modulators developed evaluated use among compounds ulipristal acetate upa proven share antiprogestin activity mifepristone mifepristone upa demonstrated effective hours unprotected intercourse upa effective levonorgestrel lng preventing appearance clinically evident pregnancies lng delays ovulation taken beginning fertile period taken later ineffective ovulation proven impair subsequent luteal function effectiveness lng decreases time elapses limited hours unprotected intercourse upa maintains consistent effectiveness days unprotected intercourse effectiveness independent days taken ability upa delay ovulation decreases progressively ovulation approaches null time luteinizing hormone peak days ovulation upa behaves placebo persistent effectiveness drug due antiovulatory action decreases sharply approaches peak level effectiveness likely due dramatic endometrial effects drug produced regardless taken effects consistently present threshold altering endometrial morphology lower threshold altering folliculogenesis
cavitation one important elements influencing performance sea water hydraulic axial piston pump understand working performance sea water hydraulic axial piston pump cavitation effects fully dynamic numerical model developed article taken account fluid compressibility effect dynamic processes gaseous vaporous pseudo cavitation cavitation damage simulation conducted three dimensional computational fluid dynamics code pumplinx cavitation characteristics pump presented set working conditions well cavitation damage power dynamic gas volume fraction vapor volume fraction inside intake piston port plate chamber test rig developed validate computational fluid dynamics simulations case sea water hydraulic axial piston pump comparisons measured simulated instantaneous discharge pressure average flow well vibration characteristics different extents cavitation varying inlet pressure rotational speed pump presented
algorithms exposure signals unknown form offered multidimensional time series subsequent presentation separate time series every mining hole points multidimensional space parameters mining holes means facilities cognitive machine graphic arts mining holes form kappa cognitive characters evidently aberrant behavior parameters mining holes educed case multidimensional terabyte time series
cognitive training allow patients alzheimer disease reinforce individual cognitive abilities present case study investigated generalizability trained cognitive skills novel tasks stability time one patient underwent structured cognitive training using geo geographical exercise cognitive optimization task whereas eight patients underwent control cognitive intervention participants performances geo task similar untrained cognitive task different untrained cognitive task recorded intervention follow trained similar untrained tasks patients controls performance significantly differed one another preliminary evidence shows cognitive training could allow patients improve maintain performance trained task also similar task
indoor visible mold growths known associated allergies respiratory illnesses however question remains compositions diversities using swab sampling high throughput dna sequencing study analyzed taxonomic compositions diversities fungi indoor surfaces laden visible mold growths residential apartments south korea sequencing results showed low species diversities shannon indices ranging mean several allergy related genera detected surface abundant cladosporium mean relative abundance occurred less abundant aspergillus rhodotorula cryptococcus alternaria crivellia diversity analyses showed significant differences fungal communities enclosed balconies indoor areas anosim emphasizing need sample multiple indoor locations assessments made indoor visible mold growths high throughput sequencing powerful characterizing compositions diversities fungal communities future studies examine relationships taxonomic compositions diversities indoor visible molds health outcomes allergies respiratory illnesses residential buildings
aim study investigate possible association single nucleotide polymorphism snp position exon osteopontin gehe opn gene ankylosing spondylitis case control association study performed patients matched controls consented participate study opn gene polymorphism detected polymerase chain reaction pcr direct sequencing frequency genotype opn gene significantly higher frequency allele significantly higher patients controls significant differences opn gene allele phenotype frequencies patients controls opn gene polymorphism appears associated susceptibility chinese patients
generalized partial element equivalent circuit peec method proposed modeling planar circuit thin narrow slot ground approach based coupled mixed potential integral equations problem mixed electric magnetic currents coupled integral equations converted lumped element circuit network using kirchhoff voltage law kirchhoff current law circuit theory full wave green functions grounded dielectric substrate problem used interactions electric current microstrip line magnetic current slot taken account introducing two kinds controlled sources generalized peec model useful signal integrity analysis multilayered circuits validate generalized model three numerical examples consisting microstrip lines slots ground presented results obtained proposed generalized peec model compared obtained commercial electromagnetic simulation software published experimental results good agreement obtained
background cardiac rehabilitation standard care patients coronary heart disease despite considerable epidemiological evidence high stress associated worse health outcomes stress management training smt included routinely component methods results one hundred fifty one outpatients coronary heart disease years age randomized weeks comprehensive comprehensive combined smt smt assessments stress coronary heart disease biomarkers obtained treatment matched sample eligible patients receive made comparison group participants followed years median years clinical events patients randomized smt exhibited greater reductions composite stress levels compared randomized alone effect driven primarily improvements anxiety distress perceived stress groups achieved significant comparable improvements coronary heart disease biomarkers participants smt group exhibited lower rates clinical events compared alone group versus hazard ratio confidence interval groups lower event rates compared group hazard ratio confidence interval conclusions enhanced smt produced significant reductions stress greater improvements medical outcomes compared standard findings indicate smt may provide incremental benefit combined comprehensive suggest smt incorporated routinely clinical trial registration url http www clinicaltrials gov unique identifier nct
adolescents participation intergroup conflicts comprises imminent global risk understanding neural underpinnings may open new perspectives assessed jewish israeli arab palestinian adolescents brain response pain ingroup outgroup protagonists using magnetoencephalography meg one one positive conflictual interactions outgroup member attitudes toward regional conflict oxytocin levels neural marker ingroup bias emerged expressed via alpha modulations somatosensory cortex characterized automatic response pain protagonists followed rebound enhancement ingroup pain adolescents hostile social interactions outgroup members uncompromising attitudes toward conflict influenced neural marker furthermore higher oxytocin levels jewish israeli majority tighter brain brain synchrony among group members arab palestinian minority enhanced neural ingroup bias findings suggest cases intractable intergroup conflict top control mechanisms may block brain evolutionary ancient resonance outgroup pain pinpointing adolescents interpersonal sociocognitive processes potential targets intervention
aimsboth amyloid deposition neuroinflammation appear early course alzheimer disease however progression neuroinflammation relationship amyloid deposition behavioral changes fully elucidated better understanding role neuroinflammation might extend current knowledge therapeutic intervention possibilities methodsthis study systematically characterized changes behavioral abnormalities app transgenic mice brain pathology measures performed post mortem brain tissues mice months resultsapp mice exhibited significant memory deficits months old aggravated later stage life however degree memory impairments reached plateau months early appearance amyloid plaques months linear increase throughout disease course cdb positive microglia glial fibrillary acidic protein gfap positive astrocytes first detected months close association amyloid plaques yet rate changes glial activation slowed months despite steady increase conclusionthese findings provided evidence neuroinflammation might involved development progression cognitive deficits app mice suggesting novel intervention prevention strategies
nonlinearity noise play significant role enormous range subjects across entire spectrum science engineering paper considers several research topics encompass area random dynamical systems rds general overview problems multidisciplinary methods required analysis relevant results achieved rds given particular emphasis developments past years first part paper focuses developing methods unravel complex interactions noise nonlinearities using mix multidisciplinary approaches theory modeling simulation practical applications research results beginning appear across entire spectrum mechanics example vibration absorbers panel flutter variable speed machining processes mixing transport phenomena fluid mechanics second part paper focuses developing new algorithms tools collection assimilation harnessing data threading together ideas ranging random dynamical systems information theory new particle filtering algorithm combines stochastic homogenization filtering theory presented importance sampling control methods used basic flexible tool construction proposal density inherent particle filtering
objectives children special health care needs shcn elevated risk chronic physical developmental behavioral emotional conditions therefore require specialized health care services study examines relationship residential neighborhood amenities physical activity among children shcn methods nationally representative sample children aged years taken national survey children health nsch residential neighborhood amenities defined parent reported presence absence sidewalks parks playgrounds recreation center physical activity measured parent reported number physically active days defined min longer past week negative binomial regressions performed estimate associations residential neighborhood amenities physical activity among children without shcn adjusting various neighborhood detracting condition safety individual characteristics nsch sampling design results approximately young children aged years adolescents aged years shcn number weekly physically active days among young children without shcn among adolescents without shcn respectively among young children shcn neighborhood availability recreation center associated increased weekly physically active days whereas among young children without shcn number weekly physically active days associated availability amenity among adolescents shcn neighborhood availability parks playgrounds associated increased weekly physically active days whereas neighborhood availability sidewalks associated reduced weekly physically active days conversely among adolescents without shcn neighborhood availability recreation center associated increased weekly physically active days conclusions practice vulnerable health status high dependence health care may prevent children shcn physically active provision adequate amenities residential neighborhoods could essential promoting physical activity preventing obesity among children adolescents shcn
paper presents development power electronics needed interaction electrical generator wind turbine isolated micro grid system basically two types receptors energy produced wind turbine loads connected isolated micro grid batteries used store energy basically two states system work one states enough wind power supply loads extra energy used charge batteries state low wind power batteries compensate lack power isolated micro grid enough power supply least priority loads paper presented hardware control algorithm developed system topology previously tested computer simulations using software psim validated implementation laboratory prototype
cocaine dependence frequently occurs personality disorders leading increased interpersonal problems greater burden disease personality disorders characterised patterns thinking feeling divert social expectations however comorbidity cocaine dependence personality disorders substantiated measures brain activation social decision making applied functional magnetic resonance imaging compare brain activations evoked social decision making taskthe ultimatum gamein cocaine dependents personality disorders cdpd cocaine dependents without comorbidities healthy controls ultimatum game participants accept reject bids made another player split monetary stakes offers varied fairness fair offers proposer shares similar percent money unfair offers proposer shares percent money participants told accept players get money reject players lose contrasted brain activations unfair versus fair offers accept versus reject choices evaluation unfair offers cdpd displayed lower activation insula anterior cingulate cortex higher activation lateral orbitofrontal cortex superior frontal temporal gyri frontal activations negatively correlated emotion recognition rejection offers cdpd displayed lower activation anterior cingulate cortex striatum midbrain dual diagnosis linked hypo activation insula anterior cingulate cortex hyper activation frontal temporal regions social decision making associates poorer emotion recognition
purpose review hepatitis virus hcv major cause clinical burden united states worldwide percentage patients develop complications cirrhosis hepatocellular carcinoma recent findings therapy chronic hcv infection previously interferon based advent direct acting antivirals daas dramatic improvement eradicating virus favourable side effect profiles summary emerging data demonstrating new successful agents difficult manage populations review aimed provide brief overview currently accepted therapy well providing new information upcoming therapeutic agents available practioners going forward
myelofibrosis myelodysplastic syndrome mds hematopoietic stem cell disorders associated cytopenias red blood cell rbc transfusion dependence iron overload consequence rbc transfusion dependence effect outcomes formally studied however demonstrated poor prognostic feature patients mds congenital acquired chronic anemias evidence iron chelation therapy ict reduces deleterious effects mds led speculation benefit however data supporting use ict lacking neither disease clear consensus guidelines use ict moreover jail stat inhibition cornerstone treatment often contributes anemia transfusional requirements manuscript reviews known potential implications highlights need prospective clinical investigations ict consideration setting jak inhibitor therapy elsevier ltd rights reserved
characteristic feature idiopathic pulmonary fibrosis ipf accumulation apoptotic resistant fibroblasts myofibroblasts fibroblastic foci caveolin cav null mice develop pulmonary fibrosis hypothesized participating fibroblasts display apoptosis resistant phenotype test hypothesis identify molecular mechanisms involved isolated lung fibroblasts cav null mice examined expression several inhibitors apoptosis iaps flip bcl proteins death receptor fas found significant increase xiap flip constitutive protein expression alteration bcl lower levels fas isolated fibroblasts treated fas ligand fasl induce apoptosis morphological biochemical alterations induced fasl similar wild type cav null mouse lung fibroblasts time course extent alterations greater cav null fibroblasts several salient features cav null fibroblasts response loss membrane potential fragmentation mitochondrial continuum concurrent caspase activation subsequent bid cleavage prior caspase activation detected furthermore antigen formation phosphatidylserine expression dna fragmentation caspase dependent sirna mediated silencing xiap flip individually combined enhanced sensitivity lung fibroblasts fasl induced apoptosis pharmacological inhibition bcl effect together findings support mechanism fas engagement activates caspase inducing mitochondrial apoptosis bid cleavage xiap flip fine tune process cell type specific manner
civil infrastructures subjected various loads lifetime leads structural degradation understand predict dynamic behaviors physical infrastructures many mathematical structural models developed subspace system identification models often require structural responses degrees freedom dofs estimate structural parameters however practice often difficult impossible make measurements owing sensing constraints lack data excessive number dofs large scale civil structures lack measurements space results ill posed problems nonunique solutions address challenge paper presents structural parameter estimation algorithm incorporates spatially incomplete measurements inaccurate prior information structural parameters within subspace system identification framework additional constraints imposed using prior information prior information updated new estimation sequentially update parameters process repeated measurements collected proposed method evaluated using numerical model story shear building two damage scenarios measurement noise structural parameters estimated accuracy spatially incomplete measurements iterative updating improves accuracies american society civil engineers
background pharmacists critical providing timely access emergency contraception knowledge counselling paramount aims describe pharmacy students knowledge attitudes toward behaviours related australian context methods questionnaire distributed five year levels pharmacy students australian university participants asked multiple response true false questions knowledge behaviours point likert scale used determine attitudes results students present survey distribution responded progression pharmacy programme correlated increasing knowledge regarding questions students advanced programme self perception competence counsel increased likely agree available without prescription requisite pharmacist counselling conclusion focused teaching impacts students knowledge intentions comply professional responsibilities supplying counselling
young people live environment sexualises particularly women along traditional gender roles parallel silence positive sexuality policy development means sexual double standards prevail young people lives aim study explore discourses young women men two european countries germany england draw making sense sexual relationships steeped local cultural climate messages study used methodology included german english young people years age six accounts emerged sex responsible intimate shared experience sex joint fun ideal versus reality sex responsible consensual shared caring relationships offer perfect context fulfilling sex equality partners importance cultural context availability specific dominant alternative discourses discussed focus influences young people sense making regard sexuality sexual relationships future directions research highlighted
earthquake behaviour four storey reinforced concrete building constructed investigated recent maintenance retrofitting numerically predicted earthquake behaviour initial structure provisions current greek seismic code demonstrated low resistance building design seismic loads estimate strength existing structural members based specific tests performed situ well laboratory strength materials structures aristotle university retrofitting scheme included strengthening vertical structural elements jacketing well use carbon fibre reinforced plastics cfrp improvement bearing capacity slabs numerically predicted earthquake behaviour retrofitted structure demonstrated sufficient resistance retrofitted building
disclosure sexual gender minority status associated positive negative effects wellbeing studies explored disclosure concealment process young people interviews conducted sexual gender minority individuals aged years male birth sex data analyzed qualitatively yielding determinants effects disclosure concealment determinants disclosure included holding positive attitudes one identity implicit devaluation acceptance society coming shown positive negative effects communication social support associated increases decreases experiences stigma determinants concealment included lack comfort one identity various motivations avoid discrimination concealment also related hypervigilance unique strategies accessing social support results discussed light clinical implications
current research paper endeavour estimate parameters near stall flight data manned unmanned research flight vehicles using conventional neural based methods aircraft undergoing stall aerodynamic model high angles attack becomes non linear due influence unsteady transient flow separation phenomena order address issues kirchhoff flow separation theory used incorporate nonlinearity aerodynamic model terms flow separation point stall characteristic parameters classical maximum likelihood mle method neural gauss newton ngn method employed estimate nonlinear parameters two manned one unmanned research aircrafts estimated static stall parameter break point flight vehicles consideration observed consistent methods moreover efficacy methods also evident consistent estimates post stall hysteresis time constant also inferred considered quasi steady model able adequately capture drag pitching moment coefficients post stall regime confidence estimates significantly enhanced observed lower values cramer rao bounds estimated nonlinear parameters validated performing proof match exercise considered flight vehicles interestingly ngn method involve solving equations motion able perform par mle method
bioinformatics umbrella term body biological studies use computer programming part methodology well reference specific analysis pipelines repeatedly used particularly fields genetics genomics data mining interdisciplinary subfield computer science computational process discovering patterns large data sets involving methods intersection artificial intelligence machine learning statistics database systems overall goal data mining process extract information data set transform understandable structure use common uses data mining bioinformatics include identification candidate genes nucleotides snps paper proposed association rule mining strategy discovery snp cancer sequences
telecare healthcare resource based new technologies services offered attempt help elderly people continue living homes sense first generation telecare services quickly developed europe aim work define profile pattern medication consumption disease frequencies elderly users telecare service cross sectional study involved spanish community dwelling elders total users aged years used telecare service end data collection period data collected march september subjects mean age years majority lived alone female mean charlson comorbidity index score mean number prescribed medications per day frequent diseases hypertension rheumatic disorders consumed medications cardiovascular nervous systems total sample three main determinants polymedication five medications hypertension anxiety depressive symptoms coronary heart disease regardless social elements contributing implementation telecare services specific health characteristics potential users morbidity polypharmacy carefully considered implementing telecare services coming years
association increased serum concentrations perfluoroalkyl substances pfas perfluorooctane sulfonate pfos perfluorooctanoate pfoa early menopause reported knox taylor association may explained fact women underwent menopause longer excrete pfas menstruation objective assess much epidemiologic association pfas altered timing menopause might explained reverse causality extended published population life stage physiologically based pharmacokinetic pbpk model pfos pfoa characterized realistic distributions physiological parameters including age menopause conducted monte carlo simulations replicate taylor population taylor knox population knox analysis simulated data overall showed pattern results comparable reported epidemiological studies example simulated knox population ages odds ratio menopause fifth quintile pfoa compared first quintile whereas reported using model structure substantial portion associations reported explained pharmacokinetics elsevier ltd rights reserved
aim present study compare response sub chronic application methamphetamine adulthood male female rats prenatally exposed drug spontaneous locomotor activity exploratory behavior adult male female rats prenatally exposed saline sal tested laboras apparatus metris netherlands five consecutive days daily sal used challenge prior testing results showed rats prenatally exposed sensitive sub chronic administration adulthood prenatally sal exposed rats however sensitizing effect prenatal exposure manifested differently males females contrast prenatal exposure decreased baseline locomotion females study indicates gender plays important role sensitivity prenatal development adulthood wiley periodicals inc dev psychobiol
retrograded starch known resistant digestion used enzyme kinetic experiments examine retrogradation starch affects amylolysis catalysed porcine pancreatic amylase parallel studies employing differential scanning calorimetry infra red spectroscopy ray diffraction nmr spectroscopy performed monitor changes supramolecular structure gelatinised starch becomes retrograded total digestible starch catalytic efficiency amylase decreased increasing evidence retrogradation purified sample retrograded high amylose starch inhibited amylase directly new findings demonstrate amylase binds retrograded starch therefore consumption retrograded starch may beneficial health depletion total digestible starch therefore metabolisable energy may also slow rate intestinal digestion direct inhibition alpha amylase physiological effects important implications prevention management type diabetes cardiovascular disease authors published elsevier ltd
arthritis vitamin insufficiency prevalent older adults risk factors disability objective study examine effect cooccurring arthritis vitamin deficiency upper lower extremity functional limitations disability older adults examined participants aged years subsample mexican health aging study measures included sociodemographics body mass index comorbid conditions falls physical activity physical function tests functional limitations activities daily living adl vitamin participants categorized four groups according arthritis vitamin status vitamin insufficiency arthritis vitamin insufficiency arthritis arthritis vitamin insufficiency fourteen percent reported arthritis vitamin insufficiency arthritis vitamin insufficiency group associated upper lower extremity functional limitations odds ratio confidence interval respectively adl disability compared vitamin insufficiency arthritis group reference group arthritis group three times likely report upper lower extremity functional limitations adl disability vitamin insufficiency group significantly associated functional limitations adl disability arthritis vitamin insufficiency increased risk adl disability population however effect arthritis vitamin insufficiency upper lower extremity functional limitations higher effect arthritis higher effect vitamin insufficiency alone
mood disorders impact social functioning might contribute experiences like affective distress might result increased cooperative behavior certain circumstances recruited participants history bipolar disorder major depressive disorder healthy controls play well validated behavioral economic trust game task provides well controlled experimental scenario measure cooperative behavior first time across groups remitted mood disordered groups cooperated significantly control group differ one another results suggest contexts history mood disturbance produce enhanced cooperation even absence current mood symptoms discuss clinical significance enhanced cooperation mood disorders point key directions future research general scientific summary individuals mood disorders suffer disruptions social functioning right circumstances might also display prosocial behaviors find individuals remission bipolar disorder major depressive disorder cooperated economic game individuals history results suggest contexts history clinical mood disturbance generates increases forms prosocial behavior even absence current mood symptoms
aim work check possibilities usage beacons find relations members cattle herd relations animals important animals welfare influence animal health productivity early stage research relations animals determined base distance animals described like like like difficult precisely determine animals like distance criterium also time direct behavior experiment carried cowshed dairy cows ble beacons bluetooth low energy beacons attached cows regularly transmitted data cows localisation cowshed smartphones distributed cowshed smartphones android system data sent relational database large amount data database data processed aggregated data transformed geometric form thanks specially developed application geometric data mapped relations written graph database graph databases useful tool analyse show relations animals neoj technology used prepare graph database ict technologies used work sql server visual studio entity framework relational databases still usefull analyse data graph databases especially useful visualize spatial relations objects new technologies allows widen perceptions create new possibilities getting knowledge lot tools connect technoogies requires multidisciplinary approach
harness heterogeneous memory hierarchy advantageous integrate application knowledge guiding frequent memory move replicating migrating virtual memory regions end present memif protected service asynchronous hardware accelerated memory move compared state art page migration linux memif incurs low overhead low latency order redefines semantics kernel interface also overhauls underlying mechanisms including request completion management race handling dma engine configuration implement memif linux server class system chip features heterogeneous memories compared current linux page migration memif reduces cpu usage small pages large pages continuously serving requests memif need request batching reduces latency crafting small runtime atop memif improve throughputs set streaming workloads overall memif opened door software management heterogeneous memory
background inhalation environmental nano particles well persistent herpesvirus infection potentially associated chronic lung disease omnipresent human society coincidence two factors highly likely hypothesized exposure persistently herpesvirus infected cells second hit might disrupt immune control viral latency provoke reactivation latent virus eventually lead inflammatory response tissue damage results test hypothesis applied different cells mice latently infected murine gammaherpesvirus mhv provides small animal model study gammaherpesvirus pathogenesis vitro vivo vitro exposure induced expression typically lytic viral gene orf production lytic virus vivo lytic viral proteins lung increased intratracheal instillation elevated expression viral gene orf could detected cells bronchoalveolar lavage gene expression metabolome analysis whole lung tissue revealed patterns striking similarities acute infection likewise exposure human cells latently infected epstein barr virus also induced virus production conclusions results indicate exposure persistently herpesvirus infected cells murine human restores molecular signatures found acute virus infection boosts production lytic viral proteins induces inflammatory response lung combination might finally result tissue damage pathological alterations
case study siennicki bridge stray current corrosion hazard presented corrosion risk caused incorrectly designed tram line traction goes bridge dielectric insulation running rails bridge steel construction used variety protection methods stray currents described characteristics endangered bridge described impressed current cathodic protection system stray currents proposed designed department electrochemistry corrosion materials engineering gdansk university technology coupon technique measurements potential measurements performed verify effectiveness protection system
investigated telling different types lies may impact memory participants studied pictures objects later lied told truth new objects multiple times describing denying seen forty eight hours later participants tested source memory results revealed participants good memory falsely described never seen object relatively poor memory falsely denied seeing studied object results suggest telling certain types lies may make person likely forget lied addition repeated truthful denials seen picture paradoxically increased false memories seen thus telling truth always prevent possibility memory distortion society applied research memory cognition published elsevier inc rights reserved
atrial fibrillation increasing burden worldwide however prevention emphasized enough clinical practice guidelines paper authors review associations modifiable lifestyle factors including alcohol abuse smoking physical inactivity unhealthy psychological stress risk development authors also review associations cardiovascular risk factors bettermanaged including obesity overweight high blood pressure diabetes dyslipidemia obstructive sleep apnea cardiovascular diseases risk conclusion high proportion prevented combining strategies focusing high risk population better risk factor management emphasizing healthy lifestyle choices whole population coll cardiol published elsevier behalf american college cardiology foundation
industry interest greater control deformations caused welding due geometric dimensional tolerances precise project specifications motivating manufacturing engineering develop stable processes ensure routine production aiming main goal present work analyze much routine situations used automatic aluminum welding influence angular deformations material using alloy automatic welding pulsed gmaw process three types weaving applied throughout length weld butt joints assembled without groove degrees single groove arranged transversely well longitudinally rolling direction plate measurement deformations made three dimensional equipment welding three distinct regions specimens profile weld bead main factor different types deformations found revealed macrographical analysis degrees single groove higher amplitudes deformations joint without groove torch oscillation variable statistically significant influence amplitudes
international conference ieee saso self adapting self organizing systems main forum studying discussing foundations principled approach engineering systems networks services based self adaptation self organization past decade consolidated primary scientific conference sharing ideas algorithms technologies tools applications across wide range scientific fields conference hosted imperial college london united kingdom scientific program comprised full papers short papers poster presentations demo sessions workshops tutorials special issue acm taas champions solid research results saso presenting selected revised extended best articles
data access delay become prominent performance bottleneck high end computing systems key reducing data access delay system design diminish data stall time memory locality concurrency two essential factors influencing performance modern memory systems however existing studies reducing data stall time rarely focus utilizing data access concurrency impact memory concurrency overall memory system performance well understood study pair novel data stall time models model combined effort locality concurrency model effect pure miss data stall time presented models provide new understanding data access delay provide new directions performance optimization based new models summary table advanced cache optimizations presented entries contributed data concurrency entries contributed data locality shows value data concurrency models associated results opportunities introduced study important necessary future data centric architecture algorithm design modern computing systems
early phases product development lifecycle large scale cyber physical systems cpss large number requirements need assigned stakeholders different organizations departments organization review clarification checking conformance standards regulations requirements various characteristics extents importance organization complexity dependencies thereby requiring different effort workload review clarify working industrial partners domain cpss discovered optimization problem optimal solution required assigning requirements various stakeholders maximizing familiarity assigned requirements meanwhile balancing overall workload stakeholder direction propose fitness function takes account mentioned factors guide search algorithm find optimal solution pilot experiment first investigated four commonly applied search algorithms avm together proposed fitness function results show performs significantly better algorithms since optimization problem multi objective empirically evaluated performance fitness function six multi objective search algorithms cellde mocell nsga paes smpso spea together best pilot study baseline terms finding optimal solution using real world case study artificial problems varying complexity results show real world case study artificial problems achieved best performance single objective nsga achieved best performance overall fitness nsga ability solve wide range problems without performance degraded significantly fit problems less requirements therefore recommend project manager interested particular objective used otherwise nsga applied obtain optimal solutions putting overall fitness first priority
introduction unknown risk loci identified genome wide association studies late onset alzheimer disease load linked common molecular mechanisms epistatic effects methods performed genome wide interaction studies five risk variants load followed enrichment analyses find pathways simultaneously interact one variant novel approach applied four independent cohorts cases controls results found enrichment epistasis gonadotropin releasing hormone signaling risk single nucleotide polymorphisms apoe msaa value value vascular smooth muscle contraction pathway also enriched epistasis loci value value msaa risk variant also interacted dilated cardiomyopathy pathway value discussion addition apoe msaa polymorphisms considered hormone trials targeting gonadotropins interactions risk variants neurovascular pathways may also important load pathology alzheimer association published elsevier inc rights reserved
traditional data storage solutions becoming expensive cumbersome support big data processing enterprises starting outsource data requirements third parties cloud service providers however outsourced initiative introduces number security privacy concerns paper homomorphic encryption suggested mechanism protect confidentiality privacy outsourced data time allowing third parties perform computation encrypted data paper also discusses challenges big data processing protection highlights differences traditional data protection existing works homomorphic encryption technically reviewed compared terms encryption scheme homomorphism classification algorithm design noise management security assumption finally paper discusses current implementation challenges future direction towards practical homomorphic encryption scheme securing outsourced big data computation
background canine atopic dermatitis common pruritic skin disease often treated allergen immunotherapy ait ait dogs traditionally begins attempting identify clinically relevant environmental allergens current allergen testing methodologies immunotherapy techniques dogs standardized immunotherapy mixture allergenic extracts selected based regional aerobiology rather intradermal tests serum ige assays described objective study evaluate effectiveness regionally specific immunotherapy dogs atopic dermatitis medical records veterinary dermatology referral clinic searched dogs atopic dermatitis began regionally specific subcutaneous immunotherapy june may overall assessment treatment effectiveness excellent good fair poor assigned based upon changes pruritus severity lesion severity reduction concurrent medication follow period least days baseline characteristics might predict treatment success analyzed spearman correlation kruskal wallis tests results dogs began regionally specific immunotherapy respit year period met inclusion criteria overall response respit classified excellent good fair poor dogs response classification correlated significantly reduction pruritus severity lesion severity dogs baseline characteristics adverse reactions reported treated dogs conclusions conditions study respit safe effective treatment atopic dermatitis dogs
aim study determine extracts selected spices caraway ginger chili sweet peppers anise sesame nutmeg black pepper might harmful people suffering celiac disease wheat allergy non celiac gluten sensitivity spice extracts exhibited reaction antibodies found sera two celiac patients sera rabbits sensitized specific peptides qqqpp pqqq qqqp peptides sequences might included active epitopes celiac disease wheat allergy methodology followed study included elisa sds page immunoblotting observed reactivities suggest spice proteins might produce adverse reactions celiac patients patients various wheat allergies non celiac gluten sensitivity however work would needed elucidate possibility
sensorless control permanent magnet synchronous machines reduces volume overall cost mechanical position sensor required zero speed lower speed range saliency based methods sensorless rotor position estimation place special demands machine electromagnetic design machine design considering typical criteria necessarily meet demands particular load dependent saturation effects often cause critical operating points vanishingly low saliency permitting reliable rotor position estimation design criteria barely investigated yet means modified rotor laminations short circuited rotor coils increasing high frequency saliency quality sensorless rotor position estimation improved specifically approaches consider boundary conditions unchanged torque density motor small increase losses rotor coils especially suitable smaller motors surface magnets lack space tolerating use buried magnets additional flux barriers appropriate design additional losses caused damping non synchronous field components negligibly small
slasher horror film deplored based claims depicts eroticized violence predominately female characters punishment sexual activities test assertion quantitative content analysis conducted examine extent gender differences evident association character survival engagement sexual activities information pertaining gender engagement sexual activities survival coded film characters simple random sample english language north american slasher films released results indicated sexual female characters less likely survive significantly longer death scenes compared female characters engage sexual behaviors
panic patients experience recurrent panic attacks two main neurochemical hypotheses proposed explain vulnerability first suggests panic patients deficient serotonergic inhibition neurons localized dorsal periaqueductal gray matter midbrain organizes defensive reactions cope proximal threats well sympathomotor control areas rostral ventrolateral medulla generate neurovegetative symptoms panic attack second proposes endogenous opioids buffer panic attacks normal subjects deficit results heightened sensitivity suffocation separation anxiety panic patients experimental results obtained rat models panic indicate serotonin interacts synergistically endogenous opioids dorsal periaqueductal gray hta opioid receptors inhibit proximal defense supposedly panic attacks findings allow reconciliation serotonergic opioidergic hypotheses panic pathophysiology also indicate endogenous opioids likely participate panicolytic action antidepressants suggest exogenous opioids may useful treating panic patients resistant conventional pharmacotherapy elsevier ltd rights reserved
first part paper docking method employed order study binding mechanism breast cancer resistance protein bcrp group previously synthesized tps derivatives known potent inhibitors protein get insight drug binding site bcrp explore structure activity relationship compounds molecular docking results showed compounds bind binding site bcrp interface membrane outer environment second part group designed tps derivatives showed good binding energies binding site alpha beta tubulin previous study chosen study binding energies binding site bcrp investigate simultaneous inhibitory effect alpha beta tubulin bcrp results showed compounds bind binding site bcrp relatively suitable binding energies therefore could potential inhibitors alpha beta tubulin bcrp proteins finally virtual consensus docking method utilized aim design new diketopiperazine derivatives significant inhibitory effect alpha beta tubulin bcrp proteins purpose binding energies library diketopiperazine derivatives binding sites alpha beta tubulin bcrp investigated using autodock autodock vina tools molecular docking results revealed group compounds among exhibit strong anti tubulin anti bcrp activity elsevier rights reserved
peer victimization associated several mental health behavioral problems childhood adolescence identifying prospective associations victimization factors known protect problems may ultimately contribute precise developmental models victimization role behavioral mental health study tested prospective associations peer victimization dispositional mindfulness defined non judgmental accepting awareness constant stream lived experience early adolescence hypothesized victimization would predict lower levels mindfulness month period study participants seventh eighth grade students female caucasian hispanic latino african american multi ethnic participating social emotional learning intervention feasibility trial structural equation model tested associations mindfulness victimization covariates baseline mindfulness victimization month posttest hypothesized baseline victimization predicted significantly lower levels mindfulness month posttest baseline mindfulness predict victimization results may reflect victimized youths mindful awareness recurrently diverted away present moment due thoughts prior impending victimization study implications may include implementing mindful awareness practices intervention strategy victimized youth enhance restore promotive factor
introducing demand response aggregator dra smart paradigm small customers actively participate price incentive based demand response programs new matter significantly affect many factors power system transmission network security accordingly notably useful define adjusted framework transmission expansion planning smart environment long term market simulation performed using tri level iterative framework find best expansion decisions transmission company transco pool based market transco investment decisions made merchant approach consistent transmission network security smart environment effects smart environment future network configuration strategic bidding generators market operation contingency analysis considered planning process effectiveness proposed method examined ieee bus system one dra one transco two generation companies independent system operator supervision copyright john wiley sons ltd
nonattachment buddhism rooted construct defined relative absence fixation ideas images sensory objects well absence internal pressure get hold avoid change circumstances experiences present study aimed exploring psychometric properties spanish version nonattachment scale nas delimitating relationship nas measures mindfulness decentering negative emotional symptoms pooling nas data spanish meditators nonmeditators performed exploratory factor analysis estimated fit two competing models one factor model one factor model method effects via confirmatory factor analysis data analyses showed spanish version nas unifactorial nature excellent internal consistency expected high positive significant correlations found nas mindfulness decentering measures well high significant negative relations nas depression anxiety stress scores positive relations also observed nas variables meditation practice large differences among meditative nonmeditative clinical groups patients borderline personality disorder observed regarding nas scores scores nas significant predictors negative emotional symptoms depression anxiety stress especially resilience furthermore nas provided unique contribution regression models going beyond mindfulness facets decentering conclusion spanish version nas psychometrically sound instrument promising future field mindfulness meditation research clinical settings
objective determine differences exist pharmacokinetics levonorgestrel based emergency contraception lng obese normal body mass index bmi users test whether doubling dose lng obese women increases total free active lng serum concentrations study design healthy reproductive age women obese normal bmis received lng orally ecx subsequent menstrual cycle obese group also received lng ecx dosing occurred follicular phase total free lng parameters obtained via serum samples indwelling catheter primary outcome difference total free lng concentration maximum cmax ecx ecx obese group results total women enrolled completed study normal bmi median range obese bmi range total lng cmax obese subjects following ecx significantly lower level observed normal bmi women notably ecx increased cmax significantly approximating level normal bmi subjects receiving ecx free lng cmax followed similar pattern conclusion obesity adversely impacts total free cmax levels lng likely explains lack efficacy obese women doubling dose appears correct obesity related changes additional research needed determine also improves effectiveness obese women implications study demonstrates obesity interferes pharmacokinetics lng doubling dose may effective strategy improve efficacy obese women elsevier inc rights reserved
vagal tone widely believed important physiological aspect emotion regulation associated positive behaviors however inconsistent evidence relations children baseline vagal tone helpful prosocial responses others hastings miller recent work adults suggests quadratic association inverted shape curve baseline vagal tone prosociality kogan present research examined whether nonlinear association evident children authors found consistent evidence quadratic relation vagal tone prosociality across samples children using different measures compared low high vagal tone moderate vagal tone early childhood concurrently predicted greater self reported prosociality study observed empathic concern response distress others greater generosity toward less fortunate peers study longitudinally predicted greater self mother teacher reported prosociality years later middle childhood study taken together findings suggest moderate vagal tone rest represents physiological preparedness tendency engage different forms prosociality across different contexts early moderate vagal tone may reflect optimal balance regulation arousal helps prepare children sympathize comfort share others
objectiveto describe characteristics industrial injury hospitalizations test hypothesis industrial injuries increasingly billed non workers compensation payers time data sourceshospitalization data state inpatient databases healthcare cost utilization project agency healthcare research quality study designretrospective secondary analyses described distribution payer age gender race ethnicity injury severity injuries identified using industrial place occurrence codes logistic regression models estimated trends expected payer principal findingsthere significant increase time odds industrial injury billed california colorado significant decrease new york states markedly different policy histories industrial injuries among older workers often billed non payer primarily medicare conclusionsfindings suggest potentially dramatic cost shifting medicare study adds limited mounting evidence least states burden non payers cover health care industrial injuries growing even related employer costs decreasingan area warrants research
diabetes mellitus bone metabolism affect mesenchymal tissues numerous epidemiological pathophysiological associations common diabetes mellitus affects bone metabolism increases fracture risk pathophysiological mechanims type type diabetes impair bone metabolism bone strength may differ outlined review direct metabolic effects additon centrally controlled endocrine loops exert suppressive effects bone formation may also stimulate bone resorption decreased bone formation combination increased bone resorption strongly increases fracture risk
state art progress structural engineering last years examined three areas spatial idealization structural elements form kinematical assumptions constitutive idealization materials form generalized stresses generalized strains relations computational implications solution strategy form closed form approximate numerical procedures structural level
created novel laminar flow based microbial fuel cell mfc array integrable scalable power sourcefor portable lab chip loc devices microfluidic mfc enabled laminar flow anolyte catholyte streams microchannel without physical membranes device harvested electricity utilizing ion transfers laminar interface acts virtual membrane array prototype incorporated four series connected fuel cells operated two common inlets continuous introduction anolyte catholyte anodic flow region microorganisms oxidized organic media completed respiration transferring electrons anodes protons generated anodic reactions passed liquid liquid interfaces traveled cathodic streams electrons moved across external resistors cathodes combined protons reduced oxidant catholyte array generated maximum power output using load outperformed single laminar flow mfc unit factor approximately series parallel application array structure using microfluidic mfcs integrated single loc device offer potential chip power generation elsevier rights reserved
bryophytes including mosses liverworts hornworts heterogeneous group terrestrial plants comprise species worldwide given various biological activities reported bryophytes huge commercial potential due minute size rather small biomass various ecosystems bryophytes seldom part ethnomedicine rarely subject medicinal chemical analyses still hundreds novel natural products isolated bryophytes bryophytes shown contain numerous potentially useful natural products including polysaccharides lipids rare amino acids terpenoids phenylpropanoids quinones many specialized metabolites additionally different bryophyte extracts isolated compounds shown antimicrobial antiviral cytotoxic nematocidal insecticidal effects smooth non striated muscles weight loss plant growth regulators allelopathic activities bryophytes also cause allergies contact dermatitis effects highlight bryophytes potential source herbal remedies production chemicals used various products
backgroundparenting coparenting important children adjustment interaction little explored using longitudinal design considering two children per family investigated mothers fathers perceptions coparenting moderators associations coercive parenting children disruptive behaviour methodsmothers fathers intact families included twins family behaviour study time child age years months sdchild age months parents reported coercive parenting children disruptive behaviour via questionnaire time child age years months sdchild age months perceptions coparenting marital relationship collected telephone interview questionnaire based reports children disruptive behaviour collected follow child age years months sdchild age months multilevel modelling used examine child specific family wide effects resultsconservative multilevel models including maternal paternal perceptions demonstrated maternal perceptions coparenting overall coercive parenting interacted prediction parent reported child disruptive behaviour specifically accounting perceived marital quality behavioural stability fathers perceptions context perceived higher quality coparenting positive association mother reported overall coercive parenting children disruptive behaviour follow conclusionswhen combined highly coercive parenting maternal perceptions high quality coparenting may detrimental children adjustment
way individuals use humor interact interpersonally associated general personality depression suicidality certain humor styles may moderate risk suicide ideation individuals high specific risk factors thwarted belongingness perceived burdensomeness previous research suggests relationship humor styles borderline personality disorder bpd increased risk suicidality suicide completion individuals bpd participants completed measures bpd traits humor styles hypothesized bpd traits would positively correlated negative humor styles negatively correlated positive humor styles humor styles would significantly moderate bpd traits results showed bpd traits negatively correlated self enhancing humor styles positively correlated self defeating humor styles significantly correlated affiliative aggressive humor styles bootstrapping analyses demonstrated affiliative self enhancing self defeating humor styles significantly moderated bpd traits aggressive humor style
theoretical concern addressing unconscious perception emotion extent participants access experiential properties masked facial stimuli performance two alternative forced choice afc task measure objective awareness compared new measure developed access experiential phenomena target mask transition perceptual contrast change sensitivity pccs measure backward masking paradigm angry happy neutral facial expressions whilst afc performance indicated targets successfully masked pccs values significantly higher happy neutral face condition angry neutral face neutral neutral face conditions experiment furthermore objective measures awareness readily displayed individuals high trait anxiety whereas individuals low trait anxiety showed greater access experiential quality happy faces experiment findings provide important insights methodological considerations involved study non conscious processing emotions respect individual differences anxiety extent certain expressions successfully masked relative others furthermore results may informative work investigating neural correlates conscious versus unconscious perception emotion elsevier inc rights reserved
introduction poor adherence infection control standards among health care professionals widespread putting patients substantial risk basic infection control skills typically learned uniprofessionally outside clinical environment real clinical settings cognitive load associated simultaneously managing challenging clinical problems part interprofessional team compounds difficulties applying infection control standards mixed methods study evaluated interprofessional education infection control module part larger action research project aimed developing interprofessional health education using simulation methods students medicine nursing physiotherapy participated pilot infection control simulation participants completed survey regarding confidence performing infection control skills perceptions interprofessional communication collaboration satisfaction module qualitative feedback obtained facilitators participants results participants reported confidence skills except enhanced precautions found interprofessional simulation based training valuable observers identified instances infection control practices appropriately followed within clinical context noted strong teamwork collaboration amongst team members several barriers learning identified majority participants indicated interprofessional infection control module mandatory health sciences students qualitative analysis revealed recommendations ways make type session effective conclusions pilot project demonstrated feasibility using high fidelity patient simulation reinforce infection control skills promote interprofessional communication teamwork study results support need senior health professional students learn practice infection control skills interprofessional manner incorporate complex clinical scenarios training international nursing association clinical simulation learning published elsevier inc rights reserved
research performed investigate ability transcranial magnetic stimulation tms evoke deeper areas brain minimal impact non target areas reach goal novel core design semi hexagonal shape arrow tips utilized collect magnetic field selected target region addition new circuit topology presented generate stimulative pulses optimal amplitude frequency duration first time research voxel resolution proposed exploited evaluate tms system accuracy study induced potential different parts brain related resolution custom made recording electrode micromanipulator employed provided linear movement rostral caudal dorsal ventral medial lateral orientations arm cortex microcontroller managed stimulation recording sessions performing finite element analysis researcher developed prototype proposed system tested vivo intact wag raj rat results showed spatial resolution could significantly enhanced employing proposed tms concept outcome animal trials raised hopes apply knowledge article clinical contexts
little known health effects school related indoor dampness microbial exposures study investigated dampness dampness related agents homes schools association allergy respiratory health effects danish pupils classroom dampness identified based technical inspection bedroom dampness parents self report classroom bedroom dust analyzed seven microbial components skin prick testing determined atopic sensitization lung function expressed scores forced expiratory volume one second zfev forced vital capacity zfvc ratio zfev zfvc using gli prediction equations parents reported children allergies airway symptoms doctor diagnosed asthma high classroom dampness bedroom dampness negatively associated zfev coef zfvc coef positively wheezing consistent findings found individual microbial components combination microbial components health outcomes among indoor risk factors environmental tobacco smoke ets decreased zfev coef zfev zfvcratio coef increased upper airway symptoms conclusion dampness classrooms may adverse respiratory health effects pupils microbial agents responsible effect remain unknown
metabolic syndrome defines cluster interrelated risk factors cardiovascular disease diabetes mellitus factors include metabolic abnormalities hyperglycemia elevated triglyceride levels low high density lipoprotein cholesterol levels high blood pressure obesity mainly central adiposity context extracellular vesicles evs may represent novel effectors might help elucidate disease specific pathways metabolic disease indeed evs terminology encompasses microparticles exosomes apoptotic bodies emerging novel mean cell cell communication physiology pathology represent new way convey fundamental information cells microstructures contain proteins lipids genetic information able modify phenotype function target cells evs carry specific markers cell origin make possible monitoring fluctuations circulation potential biomarkers inasmuch circulating levels increased metabolic syndrome patients mixed components evs content number evs derived distinct cells origin mode cell stimulation ensuing mechanisms production difficult attribute specific functions drivers biomarkers diseases review reports recent data evs different origins including endothelial smooth muscle cells macrophages hepatocytes adipocytes skeletal muscle finally microbiota bioeffectors message leading metabolic syndrome depicting complexity mechanisms involved functions reinforce hypothesis evs valid biomarkers represent targets harnessed innovative therapeutic approaches
last decade concerns veterinary students stress expressed several studies need student support become evident addition importance professional personal identity development veterinary curricula widely recognized need integrate academic professional skills instruction training personal life balance even though tools student support stress management exist within universities reports active creative practices veterinary education scarce report course organized twice optional part veterinary studies provide students tools everyday life personal development toward future veterinary career students defined learning objectives course reported received tools knowledge especially time management stress control course gave students opportunity step back busy schedules think lives actions even take concrete actions positive effect well rich qualitative material collected pilot course used developing course also development mandatory curriculum
implement bilingual teaching inevitable choice higher vocational colleges geared international standards improve professional competitive advantages practice bilingual teaching computer courses implemented school information guangzhou international economics college concerning foreign affairs foreign nationals paper actual problems bilingual teaching computer programming course emphatically analyzed related countermeasures introduced bilingual course selection improving students enthusiasm mooc flipped classroom step step bilingual teaching model practice teaching material selection aiming promote development bilingual teaching computer courses higher vocational colleges competitive power students workplace
traffic surveillance become important topic intelligent transportation systems itss aimed monitoring managing traffic flow progress computer vision video based surveillance systems made great advances traffic surveillance itss however performance existing surveillance systems susceptible challenging complex traffic scenes object occlusion pose variation cluttered background moreover existing related research mainly single video sensor node incapable addressing surveillance traffic road networks accordingly present review literature video based vehicle surveillance systems itss analyze existing challenges video based surveillance systems vehicle present general architecture video surveillance systems hierarchical networked vehicle surveillance survey different existing potential techniques different methods reviewed discussed respect module applications future developments discussed provide future needs services
paper effects shunt capacitor electrical network integrated renewable energy resources investigated proposes conduct hours load flow analyses ieee buses power system containing intermittent renewable sources modeled hourly generation profiles day using matlab program shunt capacitor connected selected load buses systems power factor changes buses evaluated day
cigarette smoking associated numerous diseases poses serious challenge current healthcare system worldwide smoking impacts innate adaptive immunity plays dual roles regulating immunity either exacerbation pathogenic immune responses attenuation defensive immunity adaptive immune cells affected smoking mainly include helper cells regulatory cells cells cells memory lymphocytes innate immune cells impacted smoking mostly dcs macrophages cells complex roles cigarette smoke resulted numerous diseases including cardiovascular respiratory autoimmune diseases allergies cancers transplant rejection etc although previous reviews described effects smoking various diseases regional immunity associated specific diseases comprehensive updated review rarely seen demonstrate impacts smoking general immunity especially major components immune cells aim systematically objectively review influence smoking major components innate adaptive immune cells summarize cellular molecular mechanisms underlying effects cigarette smoking immune system molecular pathways impacted cigarette smoking involve kappa map kinases histone modification investigations warranted understand exact mechanisms responsible smoking mediated immunopathology answer lingering questions cigarette smoking always harmful rather beneficial even though exerts dual effects immune responses
phase sensitive detection circuit tests signals according correlation reference signal input signal noise eliminated independence reference signal noise signal sensitivity detector improved significantly suppression noise work phase sensitive detection circuit designed seismometer possesses characteristics low input noise variable output gain high sensitivity feasibility phase sensitive detection circuit verified multisim signal noise ratio satisfactory
relevance applying methods energy recovery exhaust gases substantiated principle operation thermoelectric generator described variant design proposed efficiency various design methods heat exchange intensification compared designs compared baseline configuration without heat transfer intensifiers terms coefficients gas dynamic resistance ratio dimensionless criteria results comparative analysis proved applicability methods heat exchange intensification design thermoelectric generators various vehicles
work explicitly show existence two frequency regimes two dimensional hindmarsh rose neural network regimes semi discrete approximation shown described two dimensional complex ginzburg landau equation modulational instability phenomenon two regimes studied consideration given coupling intensities among neighboring neurons analytical solutions also investigated along propagation two frequency regimes waves depending coupling strength identified breathers impulses trains soliton like structures although waves two regimes appear common regions parameters phase differences noticed global dynamics system highly influenced values coupling terms values parameters high frequency regime displays modulated trains waves low frequency dynamics keeps original asymmetric character action potentials argue wide range pathological situations strong interactions among neurons responsible pathological states including schizophrenia epilepsy elsevier rights reserved
purpose study aims establish dynamic process model electromagnetic thermotherapy system ets predict temperature thermotherapy needle design methodology approach model used real time predicting static dynamic responses temperature therefore provide valuable analysis system monitoring findings electromagnetic thermotherapy process nonlinear problem system identification implemented neural network identifier simulate input output relationship real system excellent approximation ability uncertain nonlinear system system identifier ets analyzed selected recurrent neural networks models deal various treatment processes originality value elman neural network enn prediction model ets proposed study easy feasible method comparing two situations inputs fewer data trained present low mean squared error temperature response error appears within per cent enn advantages simple design stable efficacy useful establishing temperature prediction model ensure security thermotherapy
aims work improve knowledge role melanoma proliferation assess vivo therapeutic efficacy histamine clozapine jnj agonist preclinical metastatic model melanoma additionally aimed investigate combinatorial effect histamine gamma radiation radiobiological response melanoma cells results indicate metastatic melanoma cells express histamine inhibits proliferation part stimulation induces cell senescence melanogenesis daily treatment agonists exhibited significant vivo antitumor effect importantly compounds reduced metastatic potential particularly group treated jnj agonist higher specificity expressed benign malignant lesions melanocytic lineage highlighting potential clinical use histamine agonists addition histamine increased radiosensitivity melanoma cells vitro vivo conclude stimulation specific ligands may represent novel therapeutic strategy tumors express receptor furthermore increasing radiation induced response histamine could improve cancer radiotherapy treatment melanoma
study aimed explore extent association classes patterns single multiple drug use psychiatric disorders among recently incarcerated male drug users help formulate drug policies correctional facilities provide adequate treatment incarcerated drug users data recruited male first time incarcerated illicit drug users one detention center taiwan lifetime historical profiles illicit drug use assessed associations current psychiatric disorders compared community controls heroin meth amphetamine commonly used drugs among single combined users heroin users likely exhibit major depression social phobia meth amphetamine users showed psychotic disorder antisocial personality disorder community controls multiple drug users associated two thirds psychiatric disorders study suggests heroin meth amphetamine users require specific treatments may effectively address associated psychopathologic conditions interventions mental disorders detainees also recommended
global software development gsd major direction software engineering interest applying scrum practices distributed projects project stakeholder distribution gsd represented geographical distance generates challenges communication paper written evaluate effect scrum practices mitigating geographical distance based communication challenges also suggest mitigation strategies supported survey respondents study finds scrum provides advantage mitigating geographical distance based gsd communication challenges research reference guide researchers validate extend current knowledge scrum practices used mitigate geographical distance based communication challenges gsd
aim work analysis energetic economic advantage installing air cooling system inlet gas turbine set compressor combustor turbine chp plant two different solutions compared first one absorbption chiller fed heat recovery gas turbine heat exchanger second one traditional cooling system cfc compression cycle electrically fed electrical generator coupled gas turbine
strategic bidding problems electricity markets widely studied power systems often formulating complex level optimization problems hard solve state art approach solve problems reformulate mixed integer linear programs milps however computational time milp reformulations grows dramatically network size increases scheduling horizon increases randomness taken consideration paper take fundamentally different approach propose effective customized convex programming tools solve strategic bidding problem producers nodal electricity markets approach inspired schmudgen positivstellensatz theorem semi algebraic geometry several steps based upon convex optimization mixed integer programming results obtaining close optimal bidding solutions evidenced several numerical case studies besides huge advantage reducing computation time computation time state art milp approach grows exponentially increase scheduling horizon number random scenarios computation time approach increases rather linearly
paper describes collocated numerical scheme multi material compressible euler equations attempts suit parallel computing constraints main features conservativity mass momentum total energy entropy production second order time space context eulerian lagrange remap scheme planar geometry rectangular meshes propose compare remapping schemes using finite volume framework consider directional splitting fully multi dimensional remaps focus definition called corner fluxes also address issue internal energy behavior using conservative total energy remap perturbed duality kinetic energy obtained conservative momentum remap implicitly total energy remap therefore propose kinetic energy flux improves internal energy remap results context copyright john wiley sons ltd
problem solving considered fundamental human skill however large scale assessment problem solving education remains challenging task researchers argued development enhanced assessment approach joint effort multiple disciplines study three stage approach based evidence centered design framework proposed analyze problem solving behavior abilities performance approach applied assess online problem solving students shanghai primary school study reveals four clusters distinctive problem solving behavior abilities performance findings approach also corroborate results programme international student assessment shanghai students problem solving performance implications limitations study also discussed
background united states approximately million people infected hepatitis virus hcv genotypes hcv variably affect disease progression treatment response however relationships hcv genotypes liver disease progression healthcare resource utilization healthcare costs fully explored research design methods retrospective study patients chronic hepatitis chc healthcare claims large health plan used collect data patient demographic clinical characteristics main outcome measures main outcome measures include healthcare resource utilization hcru healthcare costs linked laboratory data provided genotype select measures determine liver disease severity results sample mean age years male included patients genotype descriptive analyses demonstrated variation hcv genotype liver non liver related comorbidities liver disease severity healthcare costs highest percentage patients liver related comorbidities advanced liver disease found among meanwhile patients lower hcru lowest costs patients highest total cause costs differences may reflect differing rates non liver related comorbidities cause care multivariable analyses showed genotype significant predictor costs liver disease severity compared patients significantly likely advanced liver disease patients significantly less likely advanced disease likely lower cause costs limitations results may generalizable patients outside represented commercial insurance plans analysis prevalent population may underestimate hcru costs relative sample treated patients conclusions results suggest liver disease progression varies genotype chc patients appear severe liver disease findings highlight importance effective hcv treatment patients support guidelines treatment high risk patients including
digitize subspaces euclidean ndspace present paper uses khalimsky short danger ambiguity topology adjacency localized neighborhoods points represents set points euclidean space integer coordinates namely given point epsilon paper first develops localized neighborhood epsilon denoted substantially used digitizing subspaces euclidean space recent paper han sostak comput appl math proposes connectedness preserving map short map map paper need continuous map topology develops certain isomorphism isomorphism paper turns map overcomes limitations continuous map khalimsky adjacency map brevity map map isomorphism substantially contribute applied topology including digital topology digital geometry han sostak comput appl math using map localized neighborhood develop notions lattice based map short map lattice based isomorphism brevity isomorphism used digitizing subspaces euclidean space topological approach thus approach contribute certain branches applied topology computer science image analysis image processing mathematical morphology
men testosterone levels decline per year age reduced androgen levels may directly contribute lower urinary tract symptoms bladder dysfunction although mechanisms unclear study examined effect low testosterone testosterone replacement key mechanisms involved local bladder function intraluminal release mediators atp ach response bladder distension measured whole bladders rats weeks following castration whilst bladder contractility assessed using isolated strips human urothelial cells cultured low physiological supra physiological testosterone conditions days stretch induced release atp ach measured phasic contractile activity bladder strips agonist induced reponses carbachol isoprenaline nerve evoked contractions unaffected castration acetylcholinesterase inhibitor neostigmine significantly increased amplitude phasic activity bladder strips following castration prevented testosterone replacement intraluminal ach release following bladder distension significantly reduced following castration whilst atp release unaffected contrast stretch induced atp release urothelial cells significantly enhanced low testosterone conditions whilst ach release unaltered testosterone replacement physiological levels prevented changes whilst androgen deficiency weeks directly affect contractility bladder smooth muscle urothelial mediator release sensitive changes testosterone changes mediator release may early effect decline testosterone could affect sensory pathways longer term contributing urinary symptoms bladder dysfunction seen androgen deficient men
paper fifth order variable coefficient nonlinear schrodinger equation attosecond pulses inhomogeneous optical fiber studied aid auxiliary functions obtain variable coefficient hirota bilinear equations corresponding integrable constraints constraints obtain lax pair conservation laws one two three soliton solutions via hirota method symbolic computation soliton structures interactions discussed one soliton discuss influence group velocity dispersion term alpha fifth order dispersion term delta velocities structures solitons normalized propagation along fiber derive constraint contributing stationary soliton two solitons analyze interactions different values alpha delta derive quasi periodic formulae three cases bound states alpha delta linear functions quasi periodic attraction repulsion lead redistribution energy two solitons ratios among quasi periods derived alpha delta quadratic functions ratios among also obtained alpha delta periodic functions periodic phenomena obtained three solitons including parabolic cubic periodic stationary structures interactions among different values alpha delta presented elsevier rights reserved
current brain computer interfacing bci system used many applications technology also used capturing brain signals form eeg technique intensive applications non invasive technique signal capturing due temporal resolution low set cost easy portability compared techniques eeg technique dealing low frequency signals signals plagued various noise interferences urge designing implementing accurate stabilized system acquiring low frequency signals paper aiming vlsi design testing eeg acquisition system acquire brain signals initially low power high gain generalized operational amplifier designed later suitable filter designed eliminate noise signals produced low frequency operations order capture eeg signals generalized amplifier design system consists differential amplifier followed voltage follower circuit circuit designed using cadence tool facilitates capturing transient response generation virtual layouts every blocks system designed tested individually blocks virtual layouts generated transient response system contains eeg signals different voltage levels frequencies captured
background exposure perfluoroalkyl substances pfass may disrupt reproductive function animals humans although pfass cross human placental barrier studies evaluated effects prenatal pfas exposure fetus reproductive hormones objective explore associations prenatal exposure perfluorooctane sulfonate pfos perfluorooctanoate pfoa cord blood reproductive hormones methods prospective birth cohort sapporo cohort hokkaido study included mother infant pairs recruited prenatal maternal cord blood samples pfos pfoa levels maternal blood second trimester measured via liquid chromatography tandem mass spectrometry also measured cord blood levels fetuses reproductive hormones including estradiol total testosterone progesterone inhibin insulin like factor steroid hormone binding globulin follicle stimulating hormone luteinizing hormone prolactin prl results median pfos pfoa levels maternal serum respectively fully adjusted linear regression analyses male infants maternal pfos levels significantly associated positively inhibin inversely pfoa levels positively associated inhibin levels among female infants significant inverse associations pfos levels prl levels although significant associations pfoa levels female infants reproductive hormone levels conclusions results suggest fetal synthesis secretion reproductive hormones may affected utero exposure measurable levels pfos pfoa elsevier ltd rights reserved
background evidence role gut microbiota post infectious irritable bowel syndrome ibs convincing lactobacillus spp positively affect ibs symptoms although mechanisms probiotics exert beneficial effects largely unknown aim study evaluate role lactobacillus casei postbiotic modulating inflammatory immune response ibs vivo organ culture model methods vivo cultures ileal colonic mucosa ibs diarrhea predominant subtype patients healthy controls treated lps interleukin alpha mrna levels assessed real time pcr toll like receptor tlr protein expression western blotting results baseline alpha mrna levels well tlr protein expression significantly higher mrna levels lower ibs ileum colon significantly reduced mrna levels pro inflammatory cytokines tlr increased lps stimulation protective effect pronounced treatment conclusion attenuate inflammatory mucosal response vivo organ culture model ibs
activated microglia cells mcs able release large amount inflammatory cytokines ischemic stroke exacerbates neuron damage study explored functional involvement long non coding rna incrna snhg potential regulatory mechanism activation mcs mouse model middle cerebral artery occlusion mcao microglia cell model oxygen glucose deprivation ogd made expression snhg mir plaga protein expression determined quantitative real time pcr western blot respectively dual luciferase assay used verify direct binding mir plaga flow cytometry applied measure neurons apoptosis snhg highly expressed ischemic cerebral tissues cells ogd treatment snhg knockdown could remarkably inhibit cells activation induced ogd snhg overexpression significantly promoted cells activation showing increase tnf alpha production neurons apoptosis rate additionally snhg knockdown promoted expression mir reduced plaga contrarily snhg overexpression inhibited mir expression increased plaga moreover mir overexpression also reversed effect ogd cells activation bioinformatics analysis dual luciferase assay supported snhg could bind directly mir mir pbinding site existed utr plaga mir mimic reversed increase plaga reduced high levels tnf cells induced snhg overexpression snhg increased expression plaga inhibition mir resulted activation mcs cerebral infarction ibro published elsevier ltd rights reserved
pro environmental behavioural spillover performing one pro environmental behaviour peb increases likelihood performing another identified possible way increase amount environmentally friendly behaviours individuals perform current research investigated spillover process role chronic environmental motivations goal priming behavioural similarity three studies two conducted students one conducted general australian public provided evidence suggest positive spillover occurs pebs similar terms resources required perform pebs resource dissimilar evidence suggest negative spillover instance performing one peb lessens likelihood subsequently performing another occurred chronic environmental striving seems independently influence performance pebs especially spending time environmentally friendly role priming goals spillover process remains unclear published elsevier ltd
study examines prevalence hiv aids different regions india socio demographic indicators presence hidden population infected hiv secondary data analyzed obtained national international agencies considering prevalence hiv aids india low prevalence regions last decade shown steady increase recent years productive age urbanization male gender lower level education minority religions low income mobile occupations associated hiv pandemic hidden population vulnerable hiv aids street children homeless population refugees observations help map high risk behavior groups formulate targeted strategies curb hiv menace
idiopathic pulmonary fibrosis ipf common lethal idiopathic interstitial pneumonias estimated year survival approximately making accurate diagnosis challenging crucial since following almost two decades disappointing results two compounds pleiotropic mechanisms action pirfenidone nintedanib proven effective slowing functional decline disease progression patients ipf despite major advance patients physicians alike worth remembering available drugs neither stop disease progression improve lung function following massive effort scientists patients industry number new agents high potential identified either currently tested ready clinical trials article seeks provide update diagnosis treatment ipf focusing newly available antifibrotic drugs
tries patricia tries two popular data structures storing strings let denote height trie patricia trie respectively set strings uniform distribution model strings well known logn tries logn patricia tries approaches infinity nevertheless worst case height trie unbounded height patricia trie theta better understand practical performance tries patricia tries investigate two classical data structures smoothed analysis model given set binary strings perturb set adding bernoulli random noise bit every string show resulting smoothed heights trie patricia trie theta logn elsevier rights reserved
schisantherin promising anti parkinsonism natural product however poor water solubility rapid serum clearance impose significant barriers delivery brain work aimed develop nanoparticle formulation extended circulation bloodstream consequently increased brain uptake thus potentially efficacious treatment parkinson disease spherical nanoparticles mean particle size prepared encapsulating methoxy poly ethylene glycol block poly lactic glycolic acid mpeg plga nanoparticles nps encapsulation efficiency similar drug loading similar vitro release nps lasted sustained release pattern using madin darby canine kidney mdck cell model results showed first intact nanoparticles carrying hydrophobic dyes internalized cells dyes slowly released within cells last nanoparticles free dyes externalized basolateral side cell monolayer fluorescence resonance energy transfer fret imaging zebrafish suggested nanoparticles gradually dissociated vivo time nanoparticles maintained intact intestine brain post treatment nps orally administrated rats much higher max auc observed plasma suspension furthermore brain delivery much effective nps suspension addition nps exerted strong neuroprotective effects zebrafish cell culture models protective effect partially mediated activation protein kinase akt glycogen synthase kinase beta gsk beta pathway summary study provides evidence small sized mpeg plga nanoparticles may improve cross barrier transportation oral bioavailability brain uptake bioactivity biopharmaceutics classification system bcs class compound
maximum energy release rate criterion max criterion commonly used crack propagation analysis however fracture criterion based elastic macroscopic strength materials present investigation modification made max criterion implement consideration plastic strain energy criterion extended study fatigue crack growth characteristics mixed mode cracks steel pipes predict crack propagation due fatigue loads new elasto plastic energy model presented new model includes effects material properties like strain hardening exponent yield strength sigma fracture toughness stress intensity factor ranges results obtained compared obtained using commonly employed crack growth law experimental data
background vedolizumab vdz anti integrin monoclonal antibody effective ulcerative colitis crohn disease aim study examine real world efficacy safety vdz large national patient cohort methods patients inflammatory bowel disease treated vdz prospectively followed weeks patients completed induction protocol week discontinued treatment week adverse events aes primary nonresponse included primary outcome induction clinical remission week secondary outcomes included clinical response corticosteroid free clinical remission results total patients inflammatory bowel disease unclassified centers israel included fifteen patients anti tumor necrosis factor naive previous surgery patients responded treatment achieved clinical remission achieved corticosteroid free remission week fourteen patients discontinued vdz week due primary nonresponse aes responded treatment achieved clinical remission achieved corticosteroid free remission week fifteen patients complete induction due primary nonresponse aes aes reported patients combined common nasopharyngitis skin eruptions conclusions large real world israeli cohort anti tumor necrosis factor experienced patients inflammatory bowel disease vdz effective safe induction clinical remission steroid free clinical remission
inadequate treatment pain children emergency department persistent problem health care professionals bound ethical principles provide adequate pain management children may challenging owing cognitive developmental differences lack knowledge regarding best practices barriers studies concluded immediate assessment treatment reassessment pain intervention essential self report behavioral scales available appropriate management includes pharmacologic non pharmacologic interventions specific diagnoses abdominal pain traumatic injuries well studied guidance available maximize efforts managing associated pain
research suggests men included reproductive health decision making help enhance positive health outcomes partners men affect use contraception method used men decisions may affected different factors gender education nature sexual relationship qualitative study conducted explore males experiences perceptions emergency contraception meanings males assign semistructured depth focus groups held men engage heterosexual activity recruited university setting united states participants expressed egalitarian views contraception decision making processes sense responsibility regarding reproductive decision making society negative stigma toward use however lack knowledge regarding copper intrauterine device viewed method exploring role needs men reproductive health care discussions research important growing area recommendations provided health care practitioners policy future research around men
based dynamical modeling robust trajectory tracking control spherical mobile robot proposed spherical robot composed spherical shell three independent rotors act inner driver mechanism owing rolling without slipping assumption robot subjected two nonholonomic constraints state space representation system developed using dynamical equations robot motion main contribution dynamical model based smc sliding mode controller designed position control robot parameters uncertainty unmodeled dynamics decrease chattering phenomena originated sign function well known boundary layer technique imposed smc control gains determined using lyapanov direct method way robustness zero convergence controller tracking error guaranteed wide range computer simulations performed show significant tracking performance proposed smc particular parameters uncertainty white gaussian noises simulation results show significant performance designed nonlinear control system trajectory tracking control spherical robot even presence parameters uncertainty unmodeled dynamics
main contribution paper introduction continuous improvement cycle devising teaching scenarios conducting learning experiences engineering proposed cycle consists seven steps gamification theory abet criteria combined arose adaptation gamification design framework commonly used industry specific context high quality education engineering formulated high level consequently useful practitioners different requirements expectations developed practice following proposed cycle presented discussed evaluated particular proposal applied exemplified scenario teaching introductory concepts computer programming first year course digital game used within gamified learning experience teaching tool however learning process rely solely use game moreover devised scenario purpose beyond edutainment contributing achievement student outcomes continuous improvement approach according abet quantitative qualitative evaluation developed practice performed positive impact students emotional engagement behavior observed result evaluation process
background carpal tunnel syndrome cts musculoskeletal condition often impairs fitness work aim retrospectively evaluate association physical exposures meat processing industry northern italy cts taking account non occupational factors material methods cross sectional study performed include workers males females years old working age years meat processing industries signs symptoms collected compulsory occupational medical surveillance occupational risk factors assessed questionnaire direct assessment investigators adjusted odds ratios oradj factors interest estimated binary logistic regression results diagnosis cts reported subjects incidence person years general signs symptoms cts associated following demographic factors smoking history confidence interval previous traumas upper limb hypothyroidism status case female participants previous pregnancies well personal history oral contraceptive therapy steroidal replacement therapy carpal tunnel syndrome cases associated following occupational factors day forceful hand exertion oradj repeated trauma hand oradj repeated movements wrist oradj conclusions increasing levels hand activity force associated increased cts prevalence among participants recommendations provided order reduce occupational exposure risk factors improve medical surveillance
demand additive processes provide components high technological performance became overriding regardless application area medical applications orthopedics field multimaterial orthoses splint scan clearly benefit direct additive manufacturing using hybrid process instead traditional handmade manufacturing slow expensive inaccurate difficult reproduce ability provide faster better orthoses using innovative services technologies resulting lower recovery times reduced symptoms improved functional capacity result significant impact quality life well citizens purposes work presents integrate methodology includes tridimensional scanning computer aided design modeling direct digital manufacturing multimaterial orthoses splints nevertheless additive manufacturing components functional gradients multimaterial components metal plastic great challenge since processing factors one different paper proposes addition two advanced additive manufacturing technologies selective laser melting stereolithography enabling production photopolymerization polymer voids metal mesh previously produced selective laser melting based biomimetic structures concept mesh subject previous design optimization procedure order optimize geometry minimizing mass involved evidencing increased mechanical strength among characteristics prototype hybrid additive manufacturing device developed flexibility construction geometrical freedom different materials processability demonstrated case study arm orthosis presented work
background continuation interferon ifn beta based therapies important maximum treatment effectiveness patients multiple sclerosis however real world data available discontinuation ifn beta aim cohort analysis estimate real world discontinuation rates years among patients united states taking subcutaneous ifn beta three times week tiw identify whether factors associated discontinuation change time methods patient data pooled marketscan commercial medicare supplemental healthcare claims databases patients multiple sclerosis diagnosis ifn beta tiw naive year continuous eligibility treatment prescription followed first prescription index date date discontinuation switch end observation treatment status analysed exactly years index multivariable models used identify drivers discontinuation results data patients included patients discontinued therapy discontinuation rates year years years greater proportion discontinuing patients poor adherence taking additional medication follow versus overall population factors independently associated discontinuation irrespective time therapy increasing number magnetic resonance imaging scans year adjusted odds ratio confidence interval years years adherence year years years factors associated early discontinuation year sets laboratory investigations versus none anxiolytic use follow factors associated later discontinuation years years antidepressant use follow years greater number relapses years years conclusions potential drivers discontinuation change time improved awareness drivers discontinuation could lead targeted interventions improve adherence
wireless communication systems multipath interference effects degrade snr increase ber received signals antenna arrays beamforming algorithms typically used improve system performance noise immunity non adaptive beamforming signal path gains remain unchanged power dissipation predictable snr ber depend changing statistics received signals hand adaptive beamforming signal path gains changed real time according statistics received signals snr improved ber decreased power dissipation undergoes unpredictable transients gain adaptation process transients especially detrimental battery based power management systems mobile applications paper propose fpga based methodology analysis modeling prediction power dissipation embedded array signal processing systems containing adaptive beamforming components fpga based methodology enables exploration adaptive beamforming design space terms power timing overhead arithmetic precision computational resources distinct feature methodology enables design space exploration real time actual received waveforms describe specific implementation methodology using hardware prototype based xilinx virtex fpga use prototype explore design space four channel least mean squares lms beamformer main result exploration selection adaptive algorithm design point represents best tradeoff parameter convergence machine precision energy efficiency embedded array signal processor
objective assessed knowledge level skills trained ashas providing home based newborn care methods asha two talukas anand district gujarat participated knowledge assessed using structured questionnaire certain skills assessed direct observation mannequins results mean knowledge score participants skills satisfactory asha workers temperature measurement hand washing weight measurement skin skin care respectively large variability observed self reported field performance asha workers conclusions knowledge skills asha workers region inadequate
simulations running parallel processors would synchronize processors maintain correct global order computations done either blocking computation correct order guaranteed speculatively proceeding best guess based local information later correcting errors necessary since gainful lengths speculative forays depend dynamics application software hardware runtime online control system necessary dynamically choose switch blocking speculative strategies paper formulate reversible speculative computing large scale parallel computing dynamic linear feedback control optimization system model evaluate performance terms time cost savings compared traditional forward computing illustrate exact analogy form vehicular travel dynamic delayed route information objective assist making optimal decision computational approach chosen predicting amount time cost savings losing different environments represented different parameters probability distribution functions consider cases gaussian exponential log normal distribution functions control system intended incorporating speculative parallel applications optimistic parallel discrete event simulations decide runtime extent speculative execution performed gainfully
coral reefs xisha islands also known paracel islands english south china sea experienced dramatic declines coral cover however current regional scale hard coral distribution geomorphic ecological zones essential reefs management context global warming ocean acidification well documented analyzed data field surveys landsat images map distribution hard coral within geomorphic zones reef flat ecological zones situ surveys conducted june nine reefs provided complete picture reef status regard live coral diversity evenness coral cover reef health live versus dead cover xisha islands mean coral cover damaged reefs seemed show signs recovery coral cover sheltered habitats lagoon patch reefs biotic dense zones reef flats higher large regional differences low diversity contrast exposed reef slopes high coral diversity along high equal distributions coral cover mean hard coral cover zones total xisha reef system estimated cover emergent reefs covered similar hard corals emergent reefs considered cover biotic dense zone reef flat common zone simple atolls especially broader northern reef flats total cover live dead coral reach zone showing equilibrium live dead coral opposed coral algae information regarding spatial distribution hard coral support inform management xisha reef ecosystems
european society clinical nutrition metabolism espen congress copenhagen denmark september representatives largest global parenteral enteral nutrition pen societies europe espen united states american society parenteral enteral nutrition aspen asia parenteral enteral nutrition society asia pensa latin america latin american federation parenteral enteral nutrition felanpe national pen societies around world met continue conversation diagnose malnutrition started clinical nutrition week austin texas february current thinking diagnostic approaches shared espen suggested grading approach could encompass various types signs symptoms etiologies support diagnosis aspen emphasized parties agree major published approaches espen aspen academy nutrition dietetics subjective global assessment sga propose weight loss key indicator malnutrition felanpe suggested anticipated consensus approach needs prioritize diagnostic method available everybody since resources differ globally pensa highlighted body mass index varies ethnicity race sarcopenia muscle mass evaluation important diagnosis malnutrition core working committee global leadership initiative malnutrition established comprising representatives largest pen societies lead consensus development collaboration larger working group broad global representation using mail telephone conferences face face meetings upcoming aspen espen congresses transparency external input sought objectives include consensus development around evidence based criteria broad application promotion global dissemination consensus criteria seeking adoption world health organization international classification diseases
extraction road networks urban areas remotely sensed imagery plays important role many urban applications road navigation geometric correction urban remote sensing images updating geographic information systems etc normally difficult accurately differentiate road background due complex geometry buildings acquisition geometry sensor paper present new method extracting roads high resolution imagery based hierarchical graph based image segmentation proposed method consists extracting features using gabor morphological filtering enhance contrast road non road pixels graph based segmentation consisting constructing graph representation image based initial segmentation hierarchical merging splitting image segments based color shape features post processing remove irregularities extracted road segments experiments conducted three challenging datasets high resolution images demonstrate proposed method compare similar approaches results demonstrate validity superior performance proposed method road extraction urban areas international society photogrammetry remote sensing inc isprs published elsevier rights reserved
background challenges delivering interventions pregnant smokers poorly documented also process promoting physical activity intervention pregnant smokers previously recorded study describes experiences researchers conducting randomised controlled trial physical activity aid smoking cessation pregnancy explores effectiveness future interventions could improved methods two focus groups independent facilitators conducted six researchers enrolled pregnant smokers leap trial provided interventions administered research measures topics included recruitment retention physical activity intervention pregnant smokers delivered adapted necessary suit women focus groups audio recorded transcribed verbatim subjected thematic analysis results five themes emerged related barriers enablers intervention delivery nature intervention personal characteristics trial participants practical issues researchers engagement participants training support needs researchers perceived participants may deterred intensive generic nature intervention need simultaneously quit smoking increase physical activity women also appeared hampered pregnancy ailments social deprivation poor mental health researchers observed status health professionals valued participants challenging maintain contact participants training support needs identified dealing pregnant teenagers participants friends family post natal return smoking conclusions future exercise interventions smoking cessation pregnancy may benefit increased tailoring intervention characteristics women including psychological profile socio economic background pregnancy ailments exercise preferences delivering effective physical activity intervention smoking cessation pregnancy may require comprehensive training delivering intervention particularly regard dealing teenage smokers smokers friends family well avoiding post natal return smoking
analog signal processing based radar systems enable reduction total system power consumption conventional digital signal processing based radar systems paper detection performance degradation previously proposed system based analog cross correlation due time synchronization addressed analog auto correlation based radar architecture proposed adopting digital radio frequency memory technique accurate tunable delays autocorrelation process realized probability detection performance degradation previously proposed system due mismatch evaluated simulations varying signal noise ratios mismatches matched filter proposed system probability detection performance also simulated versus varying signal noise ratios compared results previously proposed system analysis conditions proposed system beneficial previously proposed system made
determination intra tumor high uptake area using deoxy fluoro glucose fdg positron emission tomography pet imaging important consideration dose painting radiation treatment applications aim study develop framework towards automated segmentation labeling homogeneous heterogeneous tumors clinical lung fdg pet capability intra tumor high uptake region delineation utilized extended fuzzy random walk pet tumor segmentation algorithm delineate intra tumor high uptake areas tumor textural feature analysis used find relationship tumor type values segmentation accuracy evaluated quantitatively utilizing clinical fdg pet lung images patients total solid tumors volumetric analysis dice similarity coefficient dsc hausdorff distance measures extracted respect gold standard manual segmentation multi linear regression model also proposed automated tumor labeling based tfs including cross validation analysis two tailed test analysis tfs homogeneous heterogeneous tumors revealed significant statistical difference size zone variability szv intensity variability zone percentage proposed parameters iii entropy tumor volume dissimilarity high intensity emphasis hie suvmin lower statistical differences observed proposed parameter significant differences observed suvmax suvmean furthermore spearman rank analysis visual tumor labeling analysis depicted significant correlation szv entropy parameters iii tumor volume aerho moderate correlation hie homogeneity dissimilarity parameter suvmin aerho correlations observed suvmax suvmean rho multi linear regression model automated tumor labeling process resulted rmse values respectively generated tumor labeling sensitivity specificity respect baseline random walk segmentation results showed significant mean dsc suvmean error improvements homogeneous tumors heterogeneous lesions addition significant mean dsc suvmean error improvements observed tumor sub volume delineations namely proposed fuzzy method compared segmentation proposed demonstrated automatic framework significantly improved segmentation labeling homogeneous heterogeneous tumors lung fdg pet images
graphics processing unit gpu applied successfully many scientific computing realms due superior performances float pointing calculation memory bandwidth great potential power system applications static security analysis ssa appears candidate application massive alternating current power flow acpf problems need solved however applying existing gpu accelerated algorithms solve ssa problem degree parallelism limited existing researches devoted accelerating solution single acpf paper therefore proposes gpu accelerated solution creates additional layer parallelism among batch acpfs consequently achieves much higher level overall parallelism first paper establishes two basic principles determining well designed gpu algorithms limitation gpu accelerated sequential acpf solution demonstrated next first kind paper proposes novel gpu accelerated batch solver packages massive number tasks formulate new larger scale problem achieves higher level parallelism better coalesced memory accesses improve efficiency solving ssa gpu accelerated batch jacobian matrix generating contingency screening developed carefully optimized lastly complete process proposed gpu accelerated batch acpf solution ssa presented case studies bus system show dramatic computation time reduction achieved compared reported existing gpu accelerated methods comparison umfpack library based single cpu counterpart using intel xeon proposed gpu accelerated ssa framework using nvidia achieves times speedup even achieve four times speedup compared one fastest multi core cpu parallel computing solution using klu library proposed batch solving method practically promising lays critical foundation many power system applications need deal massive subtasks monte carlo simulation probabilistic power flow
storing retrieving data cloud important today environment also adds insecurity data sharing cloud would affected hacking modifying original content data secure data transmission encryption decryption followed methods existing method demands authentication security keys third party considered safe entire network becomes questionable party trustworthy paper proposes method encrypting public keys decrypting private keys would generated cloud node separate trusted authority paper also uses attribute real time parameters taken building security keys requesting nodes time dependent manner since attributes real time parameters changes random deployment add security contributing nodes furthermore parameters like busy state help route data ensure good packet delivery client data storage
employing generalized expansion method symbolic computation obtain new exact solutions dimensional generalized type kadomtsev petviashvili equation include traveling wave exact solutions non traveling wave exact solutions showed hyperbolic function trigonometric function meanwhile interesting physics structure discussed
objective increasing interest neuromodulation addiction methamphetamine abuse global health epidemic proven treatment objective study examine effects intermittent nucleus accumbens shell acbsh deep brain stimulation dbs operant methamphetamine intake methamphetamine seeking stimulation delivered environment different drug use methods eighteen rats implanted intravenous catheters bilateral acbsh electrodes subsequently underwent daily sessions lever active methamphetamine inactive reward operant chambers establish methamphetamine self administration stable responding achieved hours dbs sham treatment administered sham active separate nondrug environment prior daily operant sessions consecutive days immediately following dbs sham treatment rats placed operant chambers examine effects remote stimulation methamphetamine intake days therapy finished rats reestablished posttreatment baseline followed extinction training abstinence day relapse testing assess methamphetamine seeking behavior results decrease total methamphetamine intake rats receiving active dbs versus sham days methamphetamine administration returned baseline levels following cessation dbs therapy compared baseline drug responding methamphetamine seeking reduced dbs group sham group conclusions feasible deliver noncontinuous dbs outside drug use environment resultant decrease methamphetamine intake seeking acbsh neuroanatomical substrate psychostimulant reinforcement may target intermittent neuromodulatory therapies could administered brief periods sobriety
host cardinality defined number distinct peers host communicates network several algorithms proposed monitor network traffic identify high cardinality hosts centralized network operation center noc due massive amounts distributed data limitations transforming processing noc desirable design mergable reversible data structures summarizing traffic measurements distributed network monitoring system mergable data structure summarizes traffic measurements local monitor summaries different monitors merged noc preserving error guarantee without increasing space reversible data structure report interested high cardinality hosts efficiently using compressed information without querying every single host network paper propose new data streaming algorithm identify high cardinality hosts network wide traffic measurements algorithm introduces new mergable reversible data structure distributed network monitoring system designed noisy group testing theoretically analyzed algorithm evaluated real world data sets
discussed paper building process integrated diagnosis system satellites based multi signal model method basic idea follows firstly multi signal flow graph model satellite constructed describe testability character satellite clearly secondly based model real time fault reasoner developed detect faults indicate suspected components satellite based online telemetry data thirdly suspected components isolated activating interactive fault diagnosis process interactive diagnosis diagnostic strategy also acquired multi signal model expressed form bayesian networks achieve self learning ability last integrated diagnosis software platform satellite attitude control system real time diagnosis remote interactive diagnosis abilities developed performance verified simulation actual test data
vasculitis described types inflammatory arthritis best described widely recognised form rheumatoid vasculitis incidence systemic rheumatoid vasculitis declined significantly following general early use methotrexate rare form vasculitis treatment rheumatoid vasculitis conventionally gluco corticoids cyclophosphamide increasing role rituximab similar types vasculitis despite developments mortality rheumatoid vasculitis remains high vasculitis types inflammatory arthritis less well described treatment remains empirical elsevier ltd rights reserved
use hybrid short fibers suitable combination reinforcement cement based materials attracted widespread attention benefits compared mono fiber reinforcement recent years paper provides review recent developments area cement based composites reinforced hybrid short fibers aim paper represent effects hybridization elaborating upon chemical physical mechanical properties fibers performance fiber reinforced concretes frc provides summary existing knowledge successful use different hybrid forms combination steel polymer natural fibers cementitious composites different types hybrid system depending fiber type classified reviewed furthermore physical mechanical properties resultant composites also presented generally inclusion fibers concrete hybrid forms improves many engineering properties toughness ductility energy absorption capacity durability performance comparison mono fiber reinforcement elsevier ltd rights reserved
norm sparsity constraint widely used technique constructing sparse models paper two zero attracting recursive least squares algorithms referred rls rls derived employing norm parameter vector constraint facilitate model sparsity achieve closed form solution norm parameter vector approximated adaptively weighted norm weighting factors set inversion associated norm parameter estimates readily available adaptive learning environment rls computationally efficient rls exploiting known results linear algebra sparsity system proposed algorithms proven converge adaptive sparse channel estimation used demonstrate effectiveness proposed approach
although transpiration aquaporins long identified two key components influencing plant water status recently relations investigated detail present review first examines various facets aquaporin function stomatal guard cells shows involves transport water also molecules carbon dioxide hydrogen peroxide whole plant level changes tissue hydraulics mediated root shoot aquaporins indirectly impact plant transpiration recent studies also point feedback effect transpiration aquaporin function mechanisms may contribute difference isohydric anisohydric stomatal regulation leaf water status contribution aquaporins transpiration control goes far beyond issue water transport stomatal movements involves emerging cellular long distance signalling mechanisms ultimately act plant growth review examines relation aquaporins transpiration two key components influencing plant water status aquaporins transport water molecules carbon dioxide hydrogen peroxide stomatal movements function aquaporins roots shoots also intimately linked transpiration thus aquaporins contribute emerging cellular long distance signalling mechanisms ultimately act plant growth
objective medication adherence patients rheumatoid arthritis typically suboptimal nonadherence associated symptom worsening increased disability systematically reviewed published clinical studies evaluate methotrexate mtx adherence persistence factors associated mtx adherence persistence effect mtx nonadherence clinical outcomes methods medline embase systematically searched inception february using relevant keywords observational interventional clinical studies patients specifically reported adherence persistence mtx included data extracted using predesigned standardized template included study design patient demographics relevant outcomes main outcomes mtx adherence persistence rates patients treated mtx factors associated mtx adherence persistence results references screened articles met inclusion criteria another identified searching reference lists estimates mtx adherence varied study study heterogeneity patient populations duration followup definitions adherence methods assessment rates mtx persistence ranged year years clear trends identified factors influence mtx adherence persistence two studies suggested mtx adherence associated superior clinical outcomes conclusion mtx adherence persistence highly variable patients research necessary determine effect nonadherence health outcomes identify independent predictors nonadherence inform evidence based interventions
new systematic approach state charge sac observer design battery cells presented based purely data driven model nonlinear observer constructed key novelty unified generic framework model generation design experiments nonlinear model structure observer parametrisation presented integral part soc observers hybrid electrical vehicles dynamic battery model describes nonlinear system behaviour cell terminal voltage order enable application proposed concepts type battery chemistry data based modelling approach using architecture local model networks lmns proposed important prerequisite optimal model based experiment design ensures proper excitation system dynamics desired soc operating range covered soc estimation augmented state space representation lmn derived nonlinear observer design presented particular use fuzzy observer beneficial combination lmns since local observers time invariant greatly reduces complexity global estimator proposed concepts validated experimentally means lithium ion power cell elsevier rights reserved
source monitoring paradigm suggests dreams could important source naturally occurring false memories however malleability memories dreams remains investigated purpose study evaluate impact suggestions subsequent dream recall immediate dream recall collected sleep laboratory compared long term recall weeks later standard recall also compared hypnotic recall suggested elements reported participants hypnotic condition showed differential effect also found dreams reported long term recall probably naturally occurring false memories dreams findings suggest situations misinformation easily elicit false memories specific dreams
incontinence associated dermatitis iad condition often encountered dermatologists iad inflammatory skin condition secondary prolonged urine exposureit dermatologic sequela urinary incontinence incontinence dismissed simply age related disorder rather due number pathologic conditions either reversible manageable thus critical identify treat underlying causes urinary incontinence clinical management common medical issue restores normality patients lives also preventing future dermatologic complications article aim provide dermatologists overview iad approach diagnosis initial management urinary incontinence
combined cooling heating power cchp systems attracted substantial interest last years due higher efficiency cost benefits reducing greenhouse gases regard need less pollutant efficient energy generation technologies solar assisted combined cooling heating power scchp system office buildings iran studied four operational strategies following electrical load fel following thermal load ftl cooling demand hybrid supply optimization model studied order find optimum equipment size results hourly thermodynamic simulation one typical day summer one winter show overall system efficiency reach summer considering fel mode emission production reduced day winter considering optimization model optimization model reduce proposed system daily cost comparison strategies daily cost proposed system strategies conventional system elsevier rights reserved
background children autism spectrum disorder asd often experience significant handwriting impairment however influence time pressure overall performance unclear aim current study characterise handwriting profile children asd across non speeded speeded conditions particular focus given spacing difficulties handwriting errors aim explore relationships handwriting intellectual motor skills different task conditions method boys asd matched controls aged years completed modified version speed subtest handwriting performance test allowed ecologically valid relatively simple motoric task participants wrote simple phrase cat dog five times condition results significant group differences identified handwriting errors spacing words either condition however asd group demonstrated greater variability relative controls particularly speeded condition significant negative associations identified motor proficiency handwriting errors non speeded condition conclusions motor processes shown significant role overall handwriting proficiency appears motor ability may influence handwriting process different degrees depending nature task employed lack group differences respect handwriting errors spacing words may suggest children asd ability compensate underlying motor impairment completing well practiced writing task elsevier ltd rights reserved
despite high prevalence impact quality life costs survival still unresolved issues regarding diabetic polyneuropathy dpn lack definite knowledge pathogenesis limited preventive action glycaemic control type diabetes unavailability evidence based effective disease modifying treatment genetics provide tools address gaps ziegler gds group explore novel hypothesis genetic variability transketolase tkt might contribute susceptibility dpn patients newly diagnosed type type diabetes well characterised dpn transketolase diverts excess glycolytic metabolites hexosamine protein kinase advanced glycation endproduct pathways pentose phosphate pathway protective effect hyperglycaemia induced damage moreover thiamine derivative benfotiamine among disease modifying agents still consideration dpn treatment authors find significant associations single nucleotide polymorphisms tkt gene total symptom score thermal thresholds particular male participants type diabetes moreover measure plasma methylglyoxal glycating agent whose availability hindered tkt without however finding relation tkt single nucleotide polymorphisms link found tkt genetic variability nerve function measures considered context dpn genetic studies experimental clinical findings regarding thiamine benfotiamine conclusion available data supports decision maintain focus search dpn genetic biomarkers therapeutic attempts target thiamine tkt methylglyoxal
collaborative applications energy low delay constraints emerging various networked embedded systems like wireless sensor networks multimedia terminals conventional energy aware task allocation schemes developed collaborative applications concentrated energy saving making allocation decisions consequently length schedules generated allocation schemes could long unfavorable situations even tolerated remedy problem developed novel task allocation strategy called beata balanced energy aware task allocation collaborative applications running heterogeneous networked embedded systems beata algorithm aims blending energy delay efficiency scheme task allocations thereby making best trade offs energy savings schedule lengths addition introduce concept energy adaptive window critical parameter beata strategy fine tuning size energy adaptive window users readily customize beata meet specific energy delay trade needs imposed applications furthermore built mathematical model approximating energy consumption caused computation communication activities experimental results show beata significantly improves performance embedded systems terms energy saving schedule length existing allocation schemes
simulating nonlinear behavior complex systems requires significant computational effort despite rapid progress computing technology demand still strong efficient simulation methods diverse structural dynamics fields nonlinear system identification nonlinear system reliability addition efficiency algorithmic stability accuracy must addressed development new simulation procedures paper method treat localized nonlinearities structure efficiently accurately proposed method conditionally stable system equations separated state invariant linear part state dependent nonlinear part considered external pseudo forces act linear system response system obtained fixed point iterations pseudo forces updated convergence addition one time step ahead prediction form novel idea multiple time step ahead prediction proposed effect approach investigated shown increase algorithm efficiency stability perform numerical integration time stepping schemes like exponential first order hold method used advantage efficiency accuracy increase accuracy stability method novel second order hold equivalent derived implemented efficiency stability accuracy method demonstrated numerical examples finally method applied earthquake induced motion story building local nonlinearities elsevier ltd rights reserved
rationale targeted genetic engineering using programmable nucleases transcription activator like effector nucleases talens valuable tool precise site specific genetic modification human genome objective emergence novel technologies human induced pluripotent stem cells ipscs nuclease mediated genome editing represent unique opportunity studying cardiovascular diseases vitro methods results incorporating extensive literature database searches designed collection talen constructs knockout human genes associated cardiomyopathies congenital heart diseases talen pairs designed induce double strand dna break near starting codon gene either disrupted start codon introduced frameshift mutation early coding region ensuring faithful gene knockout observed constructs active disrupted target locus high frequencies illustrate utility talen mediated knockout technique individual genes tnnt lmna tbx myh ankrd nkx knocked high efficiency specificity human ipscs selectively targeting pathogenic mutation tnnt patient specific ipsc derived cardiac myocytes demonstrated knockout strategy ameliorates dilated cardiomyopathy phenotype vitro addition modeled holt oram syndrome ipsc cardiac myocytes vitro uncovered novel pathways regulated tbx human cardiac myocyte development conclusions collectively study illustrates powerful combination ipscs genome editing technologies understanding biological function genes pathological significance genetic variants human cardiovascular diseases methods strategies constructs ipsc lines developed study provide validated readily available resource cardiovascular research
background bipolar disorder phenomenologically biphasic disorder energy availability increased mania decreased depression consort accumulating evidence indicating increased mitochondrial respiration atp production bipolar mania contrasts decreased mitochondrial function patients euthymic depressive phase illness consequently central thesis paper bipolar disorder due phasic dysregulation mitochondrial biogenergetics elements responsible dysregulation may thus represent critical treatment targets mood disorders subject paper discussion many potential mediators mitochondrial function collectively implicated bipolar disorder levels oxidative stress pro inflammatory cytokines intracellular calcium ions higher bipolar mania euthymic depressive phases illness increased levels calcium ions partly account increased oxidative phosphorylation via well documented pathways modulation elements atp synthase likewise increased levels oxidative stress pro inflammatory cytokines lead upregulation ampk sirt sirt nadi directly stimulate oxidative phosphorylation uric acid melatonin also differentially elevated bipolar mania molecules stimulate production atp pro apoptotic neurotoxic mitotoxic effects elevated glutamate dopamine gsk bipolar mania may counterbalanced higher basal levels activity bcl pik akt environment elevated uric acid decreased bdnf summary details pathways discussed explanatory model existence increased atp generation mania also offer model explaining biphasic nature mitochondrial respiration bipolar disorder transition mania depression based increasing levels tnf alpha ros ampk sirt together antagonistic relationship kappa elsevier ltd rights reserved
economic crisis forced entrepreneurs real estate sector construction sector industry whole cleansed educated development think actions development survive future perspectives development considered therefore similar elsewhere europe world latvia appeared sectors new concepts sustainable construction low energy buildings green construction passive house lean construction sustainability related concepts creating high quality environmentally friendly healthy everyday living working space provided economic ecological social sustainability future brings significant benefits country including economy environment society latvia
proportion women obesity increases worldwide understanding influence body weight sexual behavior fertility contraceptive effectiveness critical health care professionals patients although many theorized obese women different normal weight women regarding sexual health behavior current evidence part disproves exception adolescents body image may play role riskier behavior placing greater risk unintended pregnancy given modern contraceptives originally evaluated obese women understanding weight affects contraceptive pharmacokinetics efficacy focus ongoing research evidence reassuring modern contraceptive methods safe effective obese women paper reviews known sexual contraceptive behavior well effectiveness pharmacokinetics modern contraceptives overweight obese women elsevier ltd rights reserved
standard total transfer free energies delta entropies delta amino acids pure aqueous aqueous mixtures salts aqueous organic aqueous ionic liquid non aqueous organic binary solvent briefly described transfer energies determined solubility measurements amino acids different techniques saturated solubility measurement also discussed present review solubilities six amino acids glycine okalanine alpha amino butyric acid valine phenylalanine serine summarized different solvents systems like pure water organic mixed solvents nacl water molality kcl water molality nano water kno water molality etc solubilities found agree mostly within uncertainties literatures reported chemical parts free energies delta entropies delta transfer amino acids computed subtracting cavity effects dipole dipole interaction effects total transfer energies different kind non covalent interactions directly involved solvation amino acids well protein molecules discussed briefly aqueous non aqueous binary solvent system also behavior different amino acids pure aqueous ionic liquid also discussed different field application data future prospect important modern science marked first time summarizing stability interaction amino acids pure well binary solvent system terms standard transfer free energy standard transfer entropy historical steps review elsevier rights reserved
paper presents new high input impedance electronically tunable voltage mode universal filter one input five outputs employing eight single ended operational transconductance amplifiers two grounded capacitors proposed circuit simultaneously realize voltage mode low pass band pass high pass band stop pass filter without inverting type input signals component matching conditions requirements natural frequency quality factor orthogonally controlled natural frequency also electronically tuned active passive sensitivities circuit low simulation results provided demonstrate theoretical analysis
study thermodynamics viscoelastic constitutive model developed describe behaviors typical thermo mechanical cycle experimentations model changes thermodynamic mechanics smps cooling heating process described clearly irreversible deformations calculated new type microstructure smps proposed new definitions phases active phase frozen phase set forth present study new thermodynamics viscoelastic model series two parts mechanical parts thermal parts new transform equation transformation frozen phase proposed transform delay time cooling heating rate considered transform equation transform equation based transformation frozen phase proposed describe change thermal expansion coefficient smps finally typical thermo mechanical cycle experimentation processes calculated using new thermodynamics viscoelastic constitutive model comparison calculated results experimental results rationality accuracy new thermodynamics viscoelastic constitutive model finally verified elsevier rights reserved
background infections usually involved pathogenesis spondyloarthritis spa mannose binding lectin mbl component innate immune system important role microbial defense objective study prevalence mbl deficiency spa patients well influence clinical profile diseases methods studied spa patients healthy individuals paired age gender mbl serum levels measured elisa test individuals levels considered deficient spa patients determination bath ankylosing spondylitis disease activity index basdai ankylosing spondylitis disease activity score asdas crp bath ankylosing spondylitis functional index basfi reactive protein crp erythrocyte sedimentation rate esr review clinical profile results spa patients mbl levels ranging median controls levels ranged median prevalence mbl deficiency spa patients controls association correlation found mbl levels basdai basfi age disease onset asdas crp esr crp presence uveitis hlab peripheral arthritis spa subtype conclusion mbl levels may linked occurrence spa influence phenotype
paper concerned thermoelastic suspension bridge equations memory effects suspension bridge equations without memory many classical results however suspension bridge equations viscoelastic thermal memories studied object present paper provide result global attractor thermoelastic suspension bridge equation past history
hiv human immunodeficiency virus epidemic united states remains serious public health concern despite treatment prevention efforts approximately new hiv cases transmitted year estimates indicate people diagnosed hiv living southern region united states african americans represent united states population however reported new hiv cases diagnosed within ethnic group majority cases diagnosed men united states estimated adults living hiv years older exists limited data regarding well african american men aging hiv disease purpose study explore perceptions experiences older african american men living hiv rural georgia data collected older african american men living hiv using focus groups face face personal interviews qualitative content analysis revealed six overlapping themes stigma fine time coping age related diseases hiv self care family support access resources findings study provide new insights lives rural hiv infected african american men expands understanding manage disease many return remain rural communities
past years major expansions public health insurance low income children united states medicaid children health insurance program chip state based efforts addition many low income parents gained medicaid coverage since affordable care act research date health insurance coverage among low income populations focused effect health care utilization health outcomes much less attention financial protection offers families review growing body evidence public health insurance provides important financial benefits low income families expansions public health insurance low income children adults associated reduced pocket medical spending increased financial stability improved material well families also review potential poverty reducing effects public health insurance coverage pocket medical expenses taken account defining poverty rate medicaid plays significant role decreasing poverty many children families addition public health insurance programs connect families social supports food assistance programs also help reduce poverty conclude reviewing emerging evidence access public health insurance childhood long term effects health economic outcomes adulthood exposure medicaid chip childhood linked decreased mortality fewer chronic health conditions better educational attainment less reliance government support later life sum nation public health insurance programs many important short long term poverty reducing benefits low income families children
historically magnetic resonance imaging mri contributed little study parkinson disease modern mri approaches unveiled several complementary markers useful research clinical applications iron neuromelanin sensitive mri detect qualitative changes substantia nigra quantitative mri markers derived diffusion weighted iron sensitive imaging volumetry functional brain alterations rest task performance captured functional arterial spin labeling perfusion mri markers useful diagnosis atypical parkinsonism track disease progression premotor stages diseases better understand neurobiological basis clinical deficits current research goal using mri generate time dependent models evolution biomarkers help understand neurodegeneration provide reliable markers therapeutic trials article reviews recent advances mri biomarker research high field ultra high field imaging atypical parkinsonism authors movement disorders published wiley periodicals inc behalf international parkinson movement disorder society
national spherical torus experiment nstx currently uses collection analog signal processing solutions coil protection part nstx upgrade nstx entails replacing analog systems software solution running conventional computing platform new digital coil protection system dcps replace old systems entirely also providing extensible framework allows adding new functionality desired development dcps multidiscipline engineering effort fact long trusted yet presently inadequate protection mechanisms replaced first kind system nstx led carefully crafted full featured software design real time concurrent redhawk linux provides deterministic environment software runs software architecture follows unified modeling language design industry standard patterns
objective describe characteristics outdoor soccer injury recovery among dutch soccer players design prospective cohort study setting competitive season weeks participants four hundred fifty six dutch male soccer players amateur teams main outcome measures coaches recorded individual exposure soccer activities paramedics sports trainers collected information occurrence location type circumstances consequences absenteeism medical treatment injuries results total time loss injuries sustained players injury corresponds overall density injuries per player hours training sessions soccer matches almost injuries lasted month reinjuries causing longer absence new injuries injuries given medical treatment common diagnoses muscle tendon joint ligament injuries lower extremities regaining ability fully take part soccer training matches players still reported complaints conclusions two recommendations based mentioned results prevention primarily focus common diagnoses players resuming soccer activities injury given special attention resolve remaining complaints prevent reinjuries
series different volume weights silicate based porous sound absorbing materials cured different methods contain different contents viscosity controlling agent manufactured portland cement way situ assembly sound absorbing characteristics tested devices standing wave compressive strength materials tested wdw microcomputer servo tensile compression testing machine result shows average absorption coefficient porous sound absorbing materials increasing volume weights viscosity controlling agent contents porous sound absorbing materials compressive strength separately increase decrease time different methods cure water cement ratio significantly effects high volume weight porous sound absorbing materials compressive strength
rare earth carboxylates constitute enormous group compounds various structures properties carboxylate group may bonded metal cations several ways structural aspects coordination modes presented discussed statistical point view typical groups carboxylate complexes reviewed data concerning thermodynamics formation lanthanide mostly iii complexes aggregated briefly analyzed electronic spectroscopy lanthanide carboxylates mostly focused analysis hypersensitive transitions discussed simple carboxylates acyclic aminopolycarboxylates dipicolinates exemplary systems elsevier rights reserved
given compact manifold riemannian manifold bounded geometry consider manifold imm immersions subset imm immersions property volume form pull back metric equals first show non minimal elements imm form splitting submanifold submanifold consider levi civita connection various natural sobolev metrics write geodesic equation show local well posedness many cases question natural generalization corresponding well posedness question group volume preserving diffeomorphisms importance fluid mechanics elsevier rights reserved
extensive review literature reveals adolescent male victims peer bullying suffer somatic emotional consequences victimized limited research school shooters found significant number adolescents targets bullies claimed shootings response victimization date profile school shooter although research suggested various dynamics contribute environment predispose community school shooting published nursing research examined relationship bullying school shooter adolescents experience peer bullying despite findings disciplines law enforcement education sociology psychology school nurses need part team recognize bullied teen intervene serious life threatening consequences
frequent inundation become serious problem urban areas world recent years necessary improve rainwater retention infiltration urban watershed purpose study report private rainwater retention harvesting tools facilities spread gradually steadily city smart way responding urban flood disaster risks rainwater harvesting tanks installed intensively rainwater harvesting house constructed city fukuoka japan city experienced flood disaster former enhanced users daily preparedness emergency latter inspired construction rainwater harvesting housing complex adjacent city elementary school construction november another nearby municipality inspired facilities school premises located land reclaimed old irrigation pond thus school needs adapted condition rainwater retained within school premises water used flush toilet water flowers grown pupils amounts retention discharge monitored data utilized science education big cities people tend depend much top mega system involving dredging rivers strengthening drainage systems constructing flood walls etc invites man made impervious surfaces urban areas bottom individual collaborative approaches adopted order achieve multiple purposes preventing mitigating disasters preserving conserving ecosystems nurturing rebuilding communities city authors published elsevier ltd
computer science activities young students widely used particularly visual programming environments investigated use scratch environment teaching concepts middle school students previous article meerbaum salant reported extent concepts successfully learned article look transition studying visual scratch environment middle school studying professional textual programming language java secondary school found programming knowledge experience students learned scratch greatly facilitated learning advanced material secondary school less time needed learn new topics fewer learning difficulties achieved higher cognitive levels understanding concepts although end teaching process significant differences achievements compared students studied scratch furthermore increased enrollment classes students observed display higher levels motivation self efficacy research justifies teaching general visual programming particular middle schools
indispensable constituent premises highly precious control vertical takeoff landing vtol aircrafts parameter identification received increasingly considerable attention academic community practitioners effort tackle matter better herewith put forward pid controlling particle swarm optimizer pso call proportional integral derivative pid controller inspired particle swarm optimizer idso uses novel evolutionary strategy whereby specified pid controller used improve particles local global best positions information empirical experiments conducted analytically unimodal multimodal test functions experimental results demonstrate pidso features better search effectiveness efficiency solving multimodal optimization problems compared recent variants psos performance upgraded adopting proper control law based controllers moreover pidso together least squares method genetic algorithm applied parameter estimation vtol aircraft comparison method pidso effective tool estimating parameters vtol aircraft
subchondral bone scb microdamage commonly observed traumatic joint injuries strongly associated post traumatic osteoarthritis ptoa knowledge three dimensional stress strain distribution within scb tissue helps understand mechanism scb failure may lead improved understanding mechanisms ptoa initiation prevention treatment study used high resolution micro computed tomography act based finite element modelling cartilage bone evaluate failure mechanism locations scb tissue high risk initial failure compression images five cartilage bone specimens average scb thickness used develop five based models models analysed axial compressions approximately mpa applied cartilage surface bone edges constrained strain stress based failure criteria applied evaluate failure mechanism scb tissue excessive compression articular cartilage based models predicted two locations scb high risk initial failure interface calcified uncalcified cartilage due excessive tension trabecular bone beneath subchondral plate due excessive compression based models cartilage bone enabled quantify distribution applied compression transferred articular cartilage underlying scb investigate mechanism mode scb tissue failure ultimately results help understand mechanism injury formation relation ptoa elsevier ltd rights reserved
long term organic blueberry trial planted october aurora oregon usa investigate effect mulch soil plant nutrient status plant growth berry yield irrigation requirements weed control efficacy mulch treatments applied planting weed mat geotextile douglas fir pseudotsuga menziesii sawdust compost sawdust compost applied soil covered sawdust paper addresses mulch treatment effects soil plant nutrient status first two years trial first berry harvest year yard debris compost used field experiment low soluble salt yard debris compost sawdust treatment produced greater berry yields sawdust alone first bearing season relative berry yields weedmat sawdust compost sawdust mulch positive effects compost berry yield observed across two cultivars flat raised beds two organic fertilizer sources fish emulsion feather meal applied two rates soil underlying mulch lowest acidic weed mat highest sawdust compost mulch two years compost increased soil organic matter weedmat sawdust mulch increase soil summary compost maintained soil optimum range blueberry provided plant available cations increased soil organic matter increased berry yield relative sawdust alone mechanism behind compost benefit deserve investigation
paper describes use methodology value stream mapping analysis manufacturing engineering new product introduction processes applicability usefulness technique process improvement domain explored case study production system new component part planned proven analysis enables improvement strategy manufacturing engineering process successfully outlined
potential occurrence internal parametric resonance phenomena recently indicated potential contributory cause appearance critical dynamic states long span suspension bridges time suspension bridges view flexibility prone aeroelastic response vortex shedding torsional divergence flutter paper non linear dynamic model suspension bridge devised purpose providing first attempt toward unified framework study aeroelastic internal resonance instabilities inspired pioneering work herrmann hauger analyses based linearized formulation able represent main structural non linear effects coupling given aerodynamic forces results confirm interaction aeroelastic effects non linear internal resonance leads unstable conditions wind speeds lower critical threshold standard aeroelastic predictions elsevier ltd rights reserved
asphalt shear strength tester developed advantages high precision low cost easy generalize interlayer shear strength testing scheme designed based characteristics vehicle real driving conditions considering different interlayer material types three typical binding conditions selected binding oil without binding oil geotextile binding oil kind binding condition four specimens prepared test shear strength different normal stress states comparing experimental results shear strength formulas three conditions obtained
background sports injuries often described overuse traumatic little known frequency overuse injuries particular vary different types sporting activities purpose identify differences sports relation diagnoses overuse injuries extremities oie anatomical areas likely injured adults compare findings reported youngsters identified previous review methods search made may april pubmed sportdiscus psycinfo web sciences search terms overuse injuries cumulative trauma disorders musculoskeletal injuries extremity limb physical activity sport risk factor exercises inclusion criteria prospective cross sectional study design least population years articles must clearly state reported cases classified traumatic overuse injuries relation particular sports type sample size articles must deal specific occupational subpopulations clinical populations blinded systematic review conducted results reported per anatomical site injury diagnosis different sports results identified articles included studying soccer beach volleyball triathlon general incidence estimates low never practice similar results seen children adolescents incidence estimates diagnoses oie given articles soccer making comparisons sports impossible children adolescents lower limb often affected upper contrary young people injured site adults often knee also differences diagnoses two age groups conclusion literature permit identify clearly difference incidence oie different sports showing well designed surveillance studies needed
different educational didactic papers allow students experimentally validate linear controllers reported however generally papers procedure followed select controller gains discussed lack information renders difficult experimental implementation controllers students general enough experience controller tuning motivated situation paper introduces methodology provides important information select controller gains regulation furuta pendulum methodology allows improving closed loop system performance desired direction differential flatness furuta pendulum property exploited main idea translate linear state feedback control design problem scenario classical tools root locus used example controller design directed toward reduction even elimination limit cycle effects proposal experimentally tested built furuta pendulum experimental results show closed loop system performance improved hence proposed methodology successfully validated
intelligent smart environments usually developed indoor applications like ambient assisted independent living seniors handicapped persons homes users would appreciate intelligent support various human activities also outdoor spaces streets forests elsewhere open nature extensive usage wireless sensor networks combined cloud based services possible wearable equipment seems usable efficient purpose paper sketch vision intelligent knowledge rich outdoor environment illustrated example ski resort knowledge rich outdoor environment ski resort sea resort among others could based exploitation sophisticated wireless sensor networks sending data appropriate cloud mobile access necessary information
research suggests temperamental approach withdrawal subject parenting influences studies explored specific parenting behaviors contextual novelty contribute observed pattern effects present study examined associations infant temperamental approach mother behavior introducing novel objects months temperamental approach withdrawal toddlerhood months sample infants males maternal positive affect predicted toddler approach withdrawal high approach infants maternal stimulation predicted less toddler approach withdrawal low approach infants however patterns varied intensity novelty parenting toddler outcome contexts thus maternal behavior may lead stronger associations earlier later measures approach withdrawal however effects tied contexts measurement elsevier inc rights reserved
organizations intensifying information security levels information security become essential element business management however excessive focus mere reinforcement information security placed employees stress studies confirmed negative effects stress include reduced employee productivity therefore important manage employee stress enforcing information security organization based person environment fit theory study examines employees become stressed factors behind information security stress iss differences managerial technical security oriented organizations results show work overload invasion privacy information security stressors furthermore work overload greater effect iss managerial security oriented organizations invasion privacy exerts greater influence iss technical security oriented organizations addition attitude compliance information security policy mitigates work overload invasion privacy findings used basic reference establishment employee stress management measures evaluation information security stress levels elsevier ltd rights reserved
paper one displacement monitoring technique using smartphone based laser projection sensing method proposed developed means common laser device projection plate structural displacement monitored using smartphone first laser spot centroid recognition method utilized displacement recognition next one displacement monitoring app viewer based android platform developed verify feasibility proposed method static dynamic comparison experiments using two android smartphones conducted finally mid span displacement one suspension bridge model tested using proposed technique results show technique convenient fast low cost structural displacement monitoring method reasonable precision elsevier rights reserved
digital image processing mentioned computer image processing refers process within image signals transformed digital ones computers applied process transformation generate images received human vision receiving devices types mathematics serves base digital image processing primary missions include algorithm design realization algorithm utilization computers multitude image data processed matlab already gained reputation one excellent mathematical application software high competence scientific calculation software assists image processing engineers scientific researchers offering visible reliable development tool named image processing toolbox design image processing system discourse image display paper conducts image drawing picture processing system basis digital image processing environment matlab
background objectives psoriasis common chronic inflammatory hyperproliperative skin disease known infectious agents play role triggering exacerbation disease periodontal diseases chronic inflammatory gum diseases initiated microorganisms dental plaques study intended determine role periodontal diseases chronic infective foci psoriasis materials methods total patients applied faculty medicine department dermatology inonu university diagnosed psoriasis control group consisting dermatologic patients without systemic disease similar age gender included study dental examinations subjects done community periodontal index treatment needs index system using periodontal probe results significant difference identified patients psoriasis control group terms cpi community periodontal index oral hygiene habits frequency tooth brushing flossing respectively positive correlation severities psoriasis dental disease determined difference statistically significant conclusion periodontal disease may affect psoriasis chronic infectious focus probably proinflammatory cytokines order clarify exact role periodontal disease psoriasis issue studied larger series serum cytokine levels
paper two discrete time control schemes presented induction motors ims based discrete time sliding mode technique first controller designed using equivalent control method second controller based discrete time equivalent super twisting algorithm sliding mode dynamics robustified adding integral action non measurable rotor fluxes estimated two observers first observer design based simple copy rotor flux dynamics whereas second observer design based sliding mode technique simulation study carried evaluation closed loop performance different sampling periods compare results discrete time control techniques moreover robust performance closed loop investigated external internal perturbations simulation study predicts closed loop one proposed controllers still performs well sampling time whereas control strategies start lose accuracy real time experiments finally carried good performance proposed strategy verified
purpose study determine whether superior colliculus microbat neurochemical makeup mammals examined organization choline acetyltransferase chat tyrosine hydroxylase immunoreactive fibers cells using standard immunohistochemistry antibodies chat chat fibers observed superficial layers denser deeper layers fibers classified two types small varicose fibers large varicose fibers chat cells predominantly located superficial layers diverse morphologies among well known sources cholinergic fibers mammalian pedunculopontine tegmental nucleus pptn laterodorsal tegmental nucleus ldtn contained strongly labeled chat cells cholinergic structures found parabigeminal nucleus pbg microbat brain immunoreactivity found within fibers within cells density fibers high zonal layer moderate superficial gray optic layers low deeper layers well labeled cells also observed within area locus coeruleus known sources catecholaminergic fibers mammalian although cytoarchitectural variations among species results clearly showed elaborately organized chat fibers cells microbat findings contribute significantly understanding actively constructed microbat visual systems
system identification structures one important aspects structural health monitoring accuracy efficiency identification results affected severely measurement noises especially structure system large bridge structures online system identification required paper least square estimation lse method used combined substructure approach identifying structural parameters cable stay bridge large degree freedoms online numerical analysis carried first dividing bridge structure smaller substructures estimates parameters substructure online using lse method simulation results demonstrate proposed approach capable identifying structural parameters however accuracy efficiency identification results depend highly noise sensitivities loading region loading pattern well element size
concept emulating constant phase element active scheme presented work starting novel setup characteristics element could easily derived emulation constant phase element performed scheme employs differentiator voltage current converter implementation scheme done using operational transconductance amplifiers active elements uses grounded capacitors proposed emulator accurate five decades frequency khz offers independent electronic tunability constant phase element magnitude phase angle iii bandwidth operation constant phase element designs currently available literature rely using fixed passive ladder networks thus lack flexibility tunability behavior proposed design verified post layout simulation results using cadence cmos process design kit provided austrian micro systems
first tool presented paper generic factory cost model estimate various costs multiple levels manufacturing plant model activity based means cost manufacturing operation calculated summed true per hour pound factory cost rate well exact unit cost manufacturing cost unlimited number different components estimated second tool scalable cost model estimates unit cost future integrally bladed disc blisk designs used aerospace industry gas turbine compressors tool multiplies machine cost rates calculated factory cost model operation times derived blisk scaling rules operation times often depend number blades disc diameter design variables many scaling rules based correlation operation times certain design parameters conversely remaining process times constant independent blisk geometry future process times estimated correlation operation times design parameters never perfect operation times uncertainty distributions cascaded model generate probability distribution unit cost interactive exchange detailed cost information manufacturing operation level well extrapolated operation times two cost models facilitate design manufacturing engineering concurrently optimise blisk designs manufacturing processes terms cost elsevier rights reserved
objective rare existance disease pathology background coronary artery embolization exceedingly rare cause myocardial infarction cases association prosthetic mechanical valves reported report case embolic myocardial infarction caused thrombus left atrium deranged coagulation profile patient critical mitral stenosis warfarinization case report year old woman taken catheterization lab early coronary intervention lieu non elevation myocardial infarction electrocardiography showed arrow atrial fibrillation controlled ventricular rate coronary angiography showed total occlusion mid left anterior descending artery thrombus upstream treatment tirofiban apparent thrombus dislodged distally passing bmw wire abnormalities seen intravascular ultrasound study echocardiography revealed critical mitral stenosis left atrial clot mild left ventricular dysfunction coagulation profile revealed sub therapeutic international normalized ratio levels sequential angiographic images normal intravascular ultrasound study presence atrial fibrillation confirmatory coronary embolism cause myocardial infarction anticoagulation treatment acute coronary syndrome initiated referred closed mitral valvulotomy conclusions coronary artery thromboembolism nonatherosclerotic cause acute coronary syndrome rare treatment consists aggressive anticoagulation antiplatelet therapy interventional options including simple wiring possible context primary prevention form patient education optimal anticoagulation oral vitamin antagonist medical advice imminent thromboembolic risks extreme importance
article presents new optical multi functional high resolution axis sensor serves navigate example replace standard joysticks medical devices electric wheelchairs surgical robots medical diagnosis devices light source laser diode affixed movable axis projects random geometric shape image sensor cmos ccd downstream microcontroller software identifies geometric shape center distortion size calculates coordinates processed attached devices depending image sensor use megapixels axis sensor features resolution digits right left digits interpolation values rise factor unique feature exact reproducibility deflection coordinates precise ability return neutral position moreover optical signal processing provides high level protection electromagnetic radio frequency interference sensor adaptive adjustable fit user range motion stroke force recommendation aims optimize sensor systems joysticks medical devices terms safety ease use adaptability
paper presents new converter switched reluctance motor controlling speed using soft computing technique like fuzzy logic controller flc operating modes proposed converter circuit discussed proposed converter capable minimizing torque ripple faster excitation demagnetization nature also improving average torque compared conventional converter circuit fuzzy logic controller becoming important methodology control engineering flc fast response easily modified cheaper implement require mathematical modeling perfect speed tracking peak overshoot compared conventional controller objective paper achieve desired speed response effective controller effectiveness proposed system verified using simulation simulation results carried using matlab simulink corresponding results presented
patient year old healthy female farmer treated terbinafine months primary physician exhibited discoloration thickening right big toenail concomitant paronychia direct microscopy revealed chlamydoconidia hyphae periodic acid schiff stained nail specimen showed septate hyphae basis morphological features gene analysis final diagnosis ungual hyalohyphomycosis caused fusarium proliferatum topical application efinaconazole solution cured disease months
objective assess prevalence psychotic symptoms among youths years age childhood diagnosis attention deficit hyperactivity disorder adhd combined type method participants multimodal treatment study children adhd mta local normative comparison group lncg systematically assessed years original enrollment mean age years trained research assistants administered psychosis screener positive screens referred study clinicians confirm exclude psychosis possible associations screening positive alcohol substance use assessed results data available mta participants original mta sample mean age years lncg participants original sample mean age years year twenty six mta participants lncg participants screened positive least psychotic symptom psychotic symptoms transient prevalence clinician confirmed psychotic symptoms mta group lncg greater cannabis use reported screened positive confirmed positive conclusion evidence adhd increased risk psychotic symptoms adhd normative comparison groups frequent cannabis use associated greater likelihood experiencing psychotic symptoms thus supporting recommendation youth use cannabis
pain communicated nonverbally facial expressions vocalisations bodily movements studies focussed facial display pain whereas little research postural display stimulus sets facial vocal expressions pain developed equivalent body based expressions reported development new stimulus set dynamic body postures communicate pain basic emotions stimulus set designed facilitate research bodily communication pain report phase development validation study first actors performed affective body postures pain well happiness sadness fear disgust surprise anger neutral expressions second observers independently selected best image stimuli based accuracy emotion identification valence arousal ratings third establish reliability accuracy valence rating procedure repeated second independent group participants final set images good reliability established made available results demonstrate pain along basic emotions communicated body posture cluster analysis demonstrates pain emotion recognised high degree specificity addition pain rated unpleasant negative valence expressions associated high level arousal first time specific postures communicating pain described stimulus set provided tool facilitate study nonverbal pain communication possible uses discussed international association study pain published elsevier rights reserved
alzheimer disease neurodegenerative disorder emerging evidence implicates amyloid plays critical role progression study investigated protective effect cerebrosides obtained sea cucumber senescence accelerated mouse prone samp mice vivo also studied effect cerebrosides induced cytotoxicity rat pheochromocytoma cell underlying molecular mechanisms cerebrosides ameliorated learning memory deficits accumulation demented mice decreased content malondialdehyde mda oxo dihydro deoxyguanosine ohdg hydroxy deoxyguanosine oxo nitric oxide enhanced superoxide dismutase sod activity significantly neuroprotective effect sea cucumber cerebrosides scc also verified vitro cerebrosides increased survival rate cells recovered cellular morphology downregulated protein levels caspase cleaved caspase total caspase bax upregulated protein level bcl revealing cerebrosides could inhibit induced cell apoptosis results showed protective effect scc regulated mitochondria dependent apoptotic pathway results provide new approach developing marine organisms functional foods neuroprotection
vera virtual environment reactor applications core simulator coupled neutron transport thermal hydraulics code development conscirtium advanced simulation light water reactors casl approach uncertainty quantification sensitivity analysis vera developed new toolkit created perform uncertainty quantification sensitivity analysis fuel assembly model developed simulated vera uncertainty quantification sensitivity analysis performed fourteen uncertain input parameters minimum departure nucleate boiling ratio mdnbr maximum fuel center line temperature maximum outer clad surface temperature chosen selected figures merit pearson spearman partial correlation coefficients considered figures merit sensitivity analysis coolant inlet temperature consistently influential parameter parameters used inputs critical heat flux calculation correlation shown influential mdnbr maximum fuel center line temperature maximum outer clad surface temperature elsevier ltd rights reserved
idiopathic pulmonary fibrosis ipf attracted extensive attention unexplained progressive lung scarring short median survival unresponsiveness traditional therapies despite extensive studies mechanisms underlying ipf pathoetiologies however remain poorly understood recent advances delineated potential function endoplasmic reticulum stress meeting need fibrotic response pinpointed critical role unfolded protein response upr pathways ipf pathogenesis review highlight effect stress activation upr survival differentiation function proliferation major profibrotic cells lung tissues course ipf discuss feasibility whether targeting upr components could orientation developing effective therapeutic strategies devastating disorder clinical settings
paper presents numerical analysis gas flow annular combustion chamber proto bioenergy micro gas turbine green building applications computational fluids dynamics cfd simulation conducted two dimensions turbulent flow gas phase combustion goal comparing effects different models real conditions two different turbulence models standard std epsilon renormalization group rng epsilon applied simulations fuel used biogas produced animal waste fuel consumption assumed simulations results simulations analyzed compared reference temperature mass fraction distributions gave almost results models therefore models std epsilon rng epsilon could used represent combustion process phenomenon without many significant differences
qualitative research methodology autoethnography used researcher explore lived experience father specifically focusing experiences son playing cricket autoethnography article unfolds first person narrative endeavours connect personal experiences one particular father wider social cultural aspects parent today narrative draws data spanning months explore researcher unknown world cricketing dad
present paper new memristor based oscillator obtained autonomous jerk circuit kengne nonlinear dynamics substituting nonlinear element original circuit first order memristive diode bridge model described continuous time four dimensional autonomous system smooth nonlinearities various nonlinear analysis tools phase portraits time series bifurcation diagrams poincare section spectrum lyapunov exponents exploited characterize different scenarios chaos novel circuit found system experiences period doubling crisis routes chaos one major results work finding window parameters space circuit develops hysteretic behaviors characterized coexistence four different periodic chaotic attractors values system parameters basins attractions various coexisting attractors plotted showing complex basin boundaries far authors knowledge goes novel memristive jerk circuit represents one simplest electrical circuits analog multiplier chip involved capable four disconnected coexisting attractors reported date pspice simulations nonlinear dynamics oscillator laboratory experimental measurements carried validate theoretical analysis elsevier ltd rights reserved
paper presents state space description set solutions rational corona type bezout equation starting stable state space representation given coefficient matrix words describe null space analytic toeplitz operator rational symbol terms matrices occuring realization symbol assuming operator involved right invertible state space version related tolokonnikov lemma also included
positive contact predicts reduced prejudice negative contact may increase prejudice stronger rate current project builds work four ways establishing understanding contact grounded subjective experience examining affective mediators involved negative contact prejudice relationship extending research effects positive negative contact minority groups examining contact asymmetry experimentally study introduced anger mediator relationships positive negative contact prejudice among white americans using contact measure reflected frequency intensity wide range experiences study found contact asymmetry among black hispanic americans study found initial experimental evidence contact asymmetry conclude calling nuanced understanding intergroup contact recognizes multifaceted subjective nature
convertible authentication encryption cae scheme enables signatory send secret message associated signature designated receiver dispute happens receiver ability get ordinary signature converting ciphertext signature receiver solely perform signature conversion without extra computational costs recipient signature prove actual designated recipient incorporate self certified public key scpk systems cae scheme propose cae scheme authentication computationally indistinguishable cae scheme provide robust security apply different online financial applications security analysis reflects cae scheme satisfies security requirements moreover require additional certificate verification public key authentication signature verification done single logical step finally result performance analysis shows presented cae scheme cost efficient existing scheme
study compared dissociations mental representations current ideal normal body sizes current ideal normal women anorexia nervosa group healthy women control group along lines single channel model cornelissen discrepancy current bmi groups adequately described along common linear continuum current mis perception body size mental representations ranked similarly ideal current normal group whilst estimation current much greater among group control group body dissatisfaction better explained current group bmi control group dissociation current participants bmi appears key element seeking understand elsevier ltd rights reserved
existing resource allocation approaches nowadays stochastic networks challenged meet fast convergence tolerable delay requirements present paper leverages online learning advances facilitate online resource allocation tasks recognizing central role lagrange multipliers underlying constrained optimization problem formulated machine learning task involving training operational modes goal learning sought multipliers fast efficient manner end order optimal offline learning approach developed first batch training generalized online setting procedure termed learn adapt novel resource allocation protocol permeates benefits stochastic approximation statistical learning obtain low complexity online updates learning errors close statistical accuracy limits still preserving adaptation performance stochastic network optimization context guarantees queue stability analysis simulated tests demonstrate proposed data driven approach improves delay convergence performance existing resource allocation schemes
objectives aim study determine whether presence depression associated increased likelihood hospital admission among adult patients years diagnosed head neck cancer hnc visiting emergency departments eds united states background head neck cancer associated high morbidity mortality patients cancer depression predictive increased mortality effect remains adjusting comorbidities patients cancer depressed less likely participate treatment decisions seek social support lead worsening overall health outcomes among patients hnc materials methods performed secondary analysis data nationwide emergency department sample neds united states using multivariable poisson regression estimate prevalence ratios prs confidence intervals cis included adults aged years older diagnosed hnc using international classification diseases revision icd codes controlled demographic clinical hospital characteristics multivariable models results final multivariable model adults years male hnc patients depression likely admitted following visit female hnc patients depression likely admitted stratified analysis association strongest males specific hnc oral cavity likely admitted conclusion depression associated hospital admission among adults aged hnc
phytocompounds used cosmeceuticals decades shown potential beauty applications including sunscreen moisturizing antiaging skin based therapy major concerns usage phyto based cosmeceuticals lower penetration high compound instability various cosmetic products sustained enhanced compound delivery beauty based skin therapy overcome disadvantages nanosized delivery technologies currently use sustained enhanced delivery phyto derived bioactive compounds cosmeceutical sectors products nanosizing phytocompounds enhances aseptic feel various cosmeceutical products sustained delivery enhanced skin protecting activities solid lipid nanoparticles transfersomes ethosomes nanostructured lipid carriers fullerenes carbon nanotubes emerging nanotechnologies currently use enhanced delivery phytocompounds skin care aloe vera curcumin resveratrol quercetin vitamins genistein green tea catechins successfully nanosized using various delivery technologies incorporated various gels lotions creams skin lip hair care sustained effects however certain delivery agents carbon nanotubes need studied roles toxicity review broadly focuses usage phytocompounds various cosmeceutical products nanodelivery technologies used delivery phytocompounds various cosmeceuticals various nanosized phytocompounds used development novel nanocosmeceuticals enhance skin based therapy
ground penetrating radar gpr used image detect subterranean objects example landmine detection although full inversion gpr measurements possible simple algorithms backprojection impractical using advanced algorithms involve minimization many algorithms used gpr imaging involve storage online generation huge dictionary matrix created discretizing high dimensional nonlinear model parametric model includes target features need extracted including location object orientation target type parameters added model dimensionality increases uniform sampling done high dimensional parameter space size dictionary complexity inversion algorithms rapidly grow exceeding capability real time processors paper shows strategic structuring dictionary takes advantage translational invariance model reduce dictionary storage several orders magnitude exploit fast fourier transform fast computation previously highly impractical bordering impossible gpr imaging problems
objective detailed analyses clinical characteristics myocardial infarction essential thrombocythemia polycythemia vera related complication far presented mostly case reports therefore aim retrospective analysis evaluate main cardiological hematological characteristics better understanding myocardial complications methods retrospective analysis carried involving patients diagnosed fourteen patients suffered hematological follow clinical characteristics compared patients patients exhibit major thrombotic complications stroke transient ischemic attack venous events hematological diagnosis results fourteen events occurred among patients vascular risk factors found analyzed cases complications developed within months diagnosis coronary angiography findings revealed elevation four cases non elevation significant stenosis coronary arteries requiring percutaneous coronary intervention stent implantation present seven cases three complex stenoses previous grafts stents undergone coronary artery bypass graft operations conclusion results present study suggest early detection consideration individual management vascular risk factors patients also important furthermore better theoretic understanding platelet activation role leukocytes myeloproliferative neoplasm related thrombosis could open new perspectives thrombosis prediction prevention
comorbidity eating disorders eds substance use disorders suds particular concern given high rates mortality relapse poor treatment outcomes associated disorders result growing impetus within field elucidate factors might influence aid treatment comorbidity one factor dispositional mindfulness past literature demonstrated significant relationship mindfulness eds suds however unaware research examined relationship dispositional mindfulness symptoms sample men residential treatment suds medical records men included current study alcohol drug use problems symptoms dispositional mindfulness assessed self report measures hierarchical regression analysis indicated dispositional mindfulness inversely related symptoms controlling alcohol use drug use age although results preliminary continued research area needed findings suggest may potential usefulness targeting enhancing mindfulness among patients residential treatment suds cooccurring psychiatric symptoms eds
cross cultural study examines first whether month olds helping behavior differs cultures second way caregivers socialization goals practices associated toddlers helping behavior helping behavior assessed three reach tasks increasing motivational demands found delhi toddlers helped munster toddlers regarding socialization practices sps delhi mothers compared munster mothers reported provide opportunities help family context praise less fostering toddlers prosocial behavior furthermore delhi mothers reported use punitive practices children follow helping request intra cultural level found helping positively associated punitive practices delhi sample whereas helping negatively related punitive practices providing opportunities help munster basis results first propose culture affects toddlers helping behavior time emergence second year second propose culture specific conceptions prosocial behavior influence sps parents use turn may influence children motivation underlying early prosocial behavior
myxedema psychosis uncommon patients primary hypothyroidism often disease state found patients hashimoto thyroiditis total thyroidectomy chronic hypothyroidism lead insidious onset psychiatric symptoms patients dementia delirium psychosis hallucinations coma year old man unremarkable medical history brought psychiatric emergency department new onset aggression paranoid behavior hallucinations days initial test results showed thyroid stimulating hormone level miu free thyroxin level clinical laboratory abnormalities found diagnosis myxedema psychosis established patient treated tapering doses intravenous hydrocortisone intravenous levothyroxine daily hospital day mental status began improve discharged day myxedema psychosis rarely initial presenting symptom hypothyroidism especially absence abnormal clinical laboratory findings
donald reynolds institute aging university arkansas medical sciences little rock addressing one pressing policy issues facing united states care burgeoning number older adults institute created arkansas aging initiative established seven satellite centers aging across state using million dollars annually state portion master tobacco settlement centers aging assist state population older adults many reside rural areas live poverty suffer health centers provide multiple avenues education community health care providers families caregivers arkansas aging initiative partnership local hospitals also makes geriatric primary specialty care accessible senior health clinics established across rural arkansas older adults made visits clinics sites attracted least one physician holds certificate added qualifications geriatrics one advanced practice nurse team members include geriatric medical social workers pharmacists nutritionists neuropsychologists initiative also addresses policy issues including engaging communities building partnerships programs crucial maximizing limited resources identifying opportunities change reimbursement mechanisms care provided growing number older adults believe type program potential create novel paradigm nationwide implementation
dialysis vascular access management united states changed significantly national kidney foundation kidney disease outcome quality initiative nkf kdoqi clinical practice guidelines first published centers medicare medicaid service adopted guidelines collaboration end stage renal disease networks established fistula first breakthrough initiative ffbi improve rate arteriovenous fistula use arteriovenous graft central venous catheter dialysis population implementation guidelines ffbi led significant increase arteriovenous fistula use prevalent dialysis population guidelines criticized opinion based often impractical past decades patient population undergoing dialysis become older complex comorbidities challenges creating ideal vascular access advancing knowledge access pathophysiology improved treatment options improved process care team approach model point toward diminishing relevance existing guidelines moreover several guidelines remain controversial may leading clinical decisions may unfavorable patients review discusses historical aspect vascular access care united states evolution current practice standards controversies surrounding guidelines current time published elsevier inc
series arylethenyl methylquinolinium derivatives designed synthesized based previous research arylethenylquinoline analogues multifunctional agents treatment alzheimer disease eur med chem results vitro biological activity evaluation including beta amyloid beta aggregation inhibition cholinesterase inhibition antioxidant activity showed introduction methyl quinoline ring significantly improved anti potential compounds optimal compound compound dramatically attenuated cell death glutamate induced cells preventing generation ros increasing level gsh importantly intragastric administration circle hac well tolerated doses could traverse blood brain barrier elsevier masson sas rights reserved
anomalous warm winter lead lowest winter ice extent highlights sensitivity arctic sea ice use year record improved sea ice thickness product retrieved data fusion cryosat radar altimetry soil moisture ocean salinity radiometry measurements examine impact recent temperature trend arctic ice mass balance november march find consistent drop cumulative freezing degree days across arctic negative peak anomaly degree days barents sea coinciding arctic wide average thinning march respect year average particular loss ice volume associated significant decline march first year ice volume reveals due loss multiyear ice previous years arctic ice cover becomes sensitive climate anomalies
bio electrochemical systems bess microbial systems employed produce electricity directly organic wastes along valuable chemicals production medium chain fatty acids acetate butyrate alcohols review recent updates value added chemicals production concomitantly production gaseous fuels like hydrogen methane considered cleaner environment addressed additionally bottlenecks associated conversion rates lower yields aspects mentioned spite infant stage development would future trend energy biochemicals electricity production greener cleaner pathway win win situation organic waste remediation henceforth review intends summarise foster progress made bess discusses challenges outlook future research advances elsevier ltd rights reserved
background developed evaluated feasibility peptide nucleic acid pna based fluorescence melting curve analysis fmca detect common mutations myeloproliferative neoplasms mpns methods set two separate reactions pna based fmca jak calr pleufs set mpl calr plysfs set clinical usefulness validated allele specific real time pcr fragment analysis sanger sequencing bcr abl negative mpns results limit detection lod pna based fmca approximately mutation interference reactions using mixtures different mutations observed non specific amplification observed normal control pna based fmca able detect jak calr leufs lysfs three six mpl mutations detected except three samples low mutant concentration lod jak exon mutations negative without influencing results among six variant calr exon mutations two detected method owing invading probe binding site conclusions pna based fmca detecting common jak mpl calr mutations rapid simple sensitive technique bcr abl negative mpns mutant allele time initial diagnosis elsevier rights reserved
adolescent young mothers transitioning pregnancy postpartum need maintain optimal quality life stress exposure violence intimate partner violence ipv nonpartner violence predictors poor quality life adult women however associations remain understudied among adolescent young mothers urban areas guided social ecological model current study created latent variable urban social stress examine impact urban social environment stressful life events discrimination family stress neighborhood problems quality life adolescent young mothers pregnancy postpartum current study secondary data analysis prospective cohort study expectant young mothers recruited obstetrics gynecology clinics results structural equation multigroup models found higher urban social stress predicted lower mental physical quality life pregnancy associations significantly stronger ipv exposed nonpartner violence exposed mothers postpartum period higher urban social stress predicted lower mental physical quality life associations significantly stronger ipv unexposed nonpartner violence exposed mothers stress reduction programs need help adolescent young mothers urban areas develop stress management skills specific urban social stress pregnancy parenting programs need tailored specific needs young mothers urban areas becoming sensitive role ipv nonpartner violence young women lives
paper electronic implementation fitzhugh nagumo neurons via monolithic microwave integrated circuits mmic based upon resonant tunneling diode rtd nonlinear transmission line nltl using coplanar waveguide cpw considered goals twofold framework electrical equivalent circuit emulating nonlinear active wave propagation effects shown one hand different physical mechanisms responsible time evolution given input signals key result medium supports stable stationary pulse propagation determined parameters rtd nltl independent boundary conditions hand influence specific line elements output signal waveform discussed systematic manner leads first time physical interpretation properties rtd nltl furthermore interesting technical applications multi ghz frequencies picosecond time scales result physically based ways elucidated regarding technical design compact neuromorphic electrical circuits optimized numerical simulations performed using standard mmic technologies
introduction alkaline phosphatase intracellular destruction enzyme periodontium takes part normal turnover periodontal ligament alveolar bone root cementum formation maintenance aim aim case control study evaluate enzyme alkaline phosphatase alp level saliva post menopausal women without chronic periodontitis materials methods study individuals satisfying study inclusion exclusion criteria recruited categorically divided basis gingival index probing pocket depth clinical attachment level two groups group post menopausal women clinically healthy periodontium group post menopausal women generalized chronic periodontitis clinical parameters assessed plaque index gingival index clinical attachment level cal probing pocket depth ppd unstimulated salivary samples obtained alp concentration measured using nitrophenylphosphate amino methyl propanol reagents beckman coulter auto analyser mann whitney test used find statistical difference respect clinical parameters cal ppd salivary alp levels results mean alp saliva found higher group compared group difference statistically significant value conclusion noteworthy increase alp concentration seen saliva study group may due increased periodontal inflammation post menopausal women thus salivary alp taken additional biomarker early diagnosis development progression periodontitis especially among post menopausal women
concrete cracks important representation evaluating bridge health condition conducting take appropriate actions optimize expenditure maintenance rehabilitation paper develop fully automatic machine learning based algorithm extracting cracks concrete bridge images combines modified region based active contour model image segmentation linear support vector machine using greedy search strategy noise elimination practice crack detection challenging problem subtle difference cracks noises inconsistent intensity along cracks possible shadow regions similar intensity cracks solve problems proposed method consists three steps first build high precision image acquisition framework automatically collect image sequences lower bridge slab fuse multiple sensor data computing crack parameters second develop modified region based active contour model combined iterated canny operator concrete image segmentation finally utilize novel feature selection approach based linear support vector machine greedy search strategy noise elimination provide crack width calculation method combined binary image gray scale image information evaluate proposed method collection real bridge images gathered existing bridges various weathers experimental results show proposed method achieves better performance several date algorithms elsevier rights reserved
background nepal use emergency contraceptive pill ecp increasing rapidly recent years little known profile ecp users study assesses increasing role ecp profile ecp users nepal policy programmatic concerns also addressed methods survey interviews undertaken involving women visited five metropolitan medical shops located pokhara seeking purchase ecp use descriptive statistics calculated data analysis results ecp popular among young years old educated women also nearly ecp users described recent sexual relationship infrequent casual overwhelming majority users aware ecp emergency use ecp users also aware options like condoms oral pill injectable contraceptives considerable proportion women using ecp also used methods conclusion ecp filling important unique role reducing unplanned unwanted pregnancy especially among young educated women infrequent sexual relationships
studying patterns hidden gene expression data helps understand functionality genes due large volume genes complexity biological networks difficult study resulting mass data often consists millions measurements order reveal natural structures identify interesting patterns given gene expression data set clustering techniques applied semi supervised classification new direction machine learning requires huge unlabeled data labeled data semi supervised classification general performs better unsupervised classification best knowledge works solving gene expression data clustering problem using semi supervised classification techniques current paper made attempt solve gene expression data clustering problem using multiobjective optimization based semi supervised classification technique aim attain good quality partitions using labeled data order generate labeled data initially fuzzy means clustering technique applied order automatically determine partitioning multiple cluster centers corresponding cluster encoded form string order compute quality obtained partitioning values five objective functions computed effectiveness proposed semi supervised clustering technique demonstrated five publicly available benchmark gene expression data sets comparison results existing techniques gene expression data clustering prove proposed method effective one statistical biological significance tests also carried
understanding immunologic pathways involved pathogenesis skin related diseases constantly advancing several biologic agents play important therapeutic roles management patients chronic urticaria atopic dermatitis psoriasis particularly omalizumab antihistamine resistant chronic urticaria interleukin inhibitors cryopyrin associated periodic syndrome schnitzler syndrome dupilumab recalcitrant atopic dermatitis inhibitors psoriasis therapeutic utility biologic agents patients immune related dermatologic disorders likely expand future article reviews data regarding biologic agents utility management specific skin related disorders
extracting information database system becomes primary obligation forced recognize importance providing easy access information stored database system however existing tools allow users query database using database query languages sql structured query language difficult non experts users wherefore asking questions databases natural language simple method provide powerful improvements use data stored databases paper presents architecture implementation generic natural language interface based machine learning approach relational database advantage interface functions independently database domain automatically improves experience knowledge base
according international recommendations selection biologic disease modifying anti rheumatic drug bdmard rheumatoid arthritis mainly left clinician preference analyzed real life factors influencing first line choice switching strategy focusing prescription abatacept aba tocilizumab tcz compared tnf alpha inhibitors tnfi patients enrolled lombardy rheumatology network lorhen registry january considered bdmard agents available included population divided first second line bdmard included patients first line second line age higher aba tcz tnfi treated patients positive latent tuberculosis screening associated first line aba methotrexate mtx combination therapy lower tcz group type dyslipidemia hypertension pulmonary disease number comorbidities influenced choice towards aba multinomial logistic regression demonstrated second line treatment higher age dyslipidemia pulmonary disease comorbidities extra articular manifestations associated aba compared tnfi tcz associated second line treatment higher age severe disease activity stopping first bdmard due adverse events influenced choice towards aba real life higher age comorbidities influence choice towards aba tcz compared tnfi aba preferred case suspension previous treatments due failing first line tnfi swapping different mechanism action common
security privacy issues magnified velocity volume variety big data user privacy even sensitive topic attracting people attention xcodeghost malware ios emerging late leads privacy leakage large number users studies examined xcodeghost based source code paper describe observations monitoring network activities million iphone users provincial area across days analysis reveals number interesting points example propose decay model prevalence rate xcodeghost find ratio infected devices lot popular applications wechat railway didi taxi youku video also infected duration well traffic volume xcodeghost related http requests similar usual http request makes difficult found besides propose heuristic model based fingerprint web knowledge identify infected applications identifying result shows efficiency model
objectives assess gender related differences cohort patients psoriatic arthritis psa methods consecutively recruited patients included underwent clinical radiological laboratory evaluation using standardized protocol case report forms results women psa higher symptom duration body mass index bmi tender swollen joint counts disease activity score joints das erythrocyte sedimentation rate esr poorer physical activity fatigue men psa psoriasis area severity index pasi higher male patients however quality life physical mental component scores articular pattern extra articular features including uveitis iritis family history psoriasis spondyloarthritis spa psa ankylosing spondylitis quite similar men women conclusions clinical laboratory variables tend different men women psa extent quality life articular pattern seem similar genders men psa likely higher pasi scores longer duration develop arthritis onset psoriasis women likely higher disease activity report fatigue physical activity limitations
paper conduct theoretical research contemporary architecture engineering construction management optimization approach background green architecture recent years concept green environmental protection becoming thorough popular feeling also makes green building arises historic moment become focal point construction projects present stage however process green building design especially design management existed many problems defects needs green building management strictly follow environmental protection design concept strictly quality pass paper comprehensive analysis green building design management order provide reference paradigm development
despite differences human language vocal communication nonhuman primates share many features constitute forms coordinated activity rely many shared neural mechanisms involve discrete combinatorial cognition includes rich pragmatic inference common features suggest evolution ancestors modern primates faced similar social problems responded similar systems communication cognition language later evolved common foundation many distinctive features already present
well known built voltage potential select semiconductor junctions various rectifying devices proposed favorable generating electricity zero bias bias voltage applied presence johnson noise noise originates quantum vacuum koch koch discovery certain solid state devices exhibit measurable quantum noise also recently labeled finding dark energy lab beck mackey tunnel diodes class rectifiers qualified credited conducting quantum fluctuations microwave diodes also good choices since many designed zero bias operation completely passive unamplified zero bias diode converter detector millimeter ghz waves developed hrl labs darpa contract utilizing based backward tunnel diode btd reported true zero bias diode developed field radiometer collect thermally radiated power words night vision diode array mounting allows feed horn antenna functions passive concentrating amplifier important clue noise equivalent power per root hertz noise equivalent temperature difference degrees indicate sensitivity johnson noise lynch also inventions single electron transistors also highest signal noise ratio near zero bias furthermore ultrasensitive devices convert radio frequencies invented operate outer space temperatures degrees zero point degrees devices tiny nanotech devices suitable assembly parallel circuits array possibly produce zero point energy direct current electricity significant power density brenning photovoltaic junction cells also considered possible higher frequency zpe transduction diode arrays self assembled molecular rectifiers preferably nano sized cylindrical diodes shown reasonably provide rectification electron fluctuations thermal non thermal zpe sources create alternative energy electrical generator picowatt per diode range
practice effective exhaust waste heat recovery heat exchanger must exhibit high heat transfer performance reasonable pressure drop achieve high net power output therefore complete numerical thermoelectric generator teg model used engine exhaust gas heat recovery presented paper based common plate type exhaust heat exchanger model considered temperature gradient along fluid flow direction also included fluid heat transfer flow resistance characteristics interaction relationships exchanger scales heat transfer flow resistance characteristics thermoelectric performance mainly studied study numerical simulations using fortran program results show high teg power achieved small cross section area corresponding small optimal module area small height required cross section area constant obtain maximum net power fluid flow resistance optimal cross section area optimal scales height length applied automotive vehicle exchanger scales available wide optimal design range help achieve high net power output scale optimization match met elsevier ltd rights reserved
coalition structure generation problem well known area multi agent systems goal establish coalitions agents maximizing global welfare among existing different algorithms designed solve coalition structure generation problem idp ones smaller temporal complexity analyzing operation dynamic programming improved dynamic programming algorithms identified frequent operations propose optimized method addition study implement method dividing work different threads describe incremental improvements algorithm design first compare performance improved single central processing unit core version obtain speedups ranging describe best resource use multi thread optimized version obtain additional speedup running core machine
delusion central conceptualization definition identification schizophrenia however current classifications presence delusions neither necessary sufficient diagnosis schizophrenia sufficient exclude diagnosis psychiatric conditions partly consequence classification rules possible delusions exist transdiagnostically article evaluate extent happens ways characteristics delusions vary according diagnostic context able examine presence form delusional disorder affective disorder obsessive compulsive disorder borderline personality disorder dementia appreciable presence evidence mechanisms delusion formation least extent shared across disorders transdiagnostic extension delusions argument targeting therapeutically right however dearth research enable rational transdiagnostic deployment either pharmacological psychological treatments
finnish patient data repository nationwide electronic health record ehr system collecting patient data healthcare providers usefulness large amount data stored system depends underlying data structures thus solid understanding structures focus development data repository study seeks improve understanding systematic literature review review takes physician perspective use usefulness data structures articles included review study data structures intended used actual care process secondary use nursing aspects covered separate reviews applying predefined inclusion exclusion criteria articles included review research widespread systems everyday use especially scarce studies concentrated narrow fields majority studies primarily developed specialist use secondary care units structures applications studied early stage development many applications use structured data found improve completeness documented data facilitate automated use however seem applications narrative text easily replaced structured data usability results regarding structured representation conflicting scattered nature paucity research hinders generalizability findings system design implementation point view practical value scientific literature reviewed limited
exoskeleton robots categorized rehabilitating assisting robots could applied applications power augmentation systems haptic systems virtual reality considering increasing number old people suffer physical weakness kinds disabilities need exploiting rehabilitation mechanisms processes one important issues field paper simple upper limb exoskeleton one degree freedom studied developed joint torque estimation corresponding biological movements well safety issues considered kinematic parameters upper limb needed design robot thus mechanism designed derive set data prototype exoskeleton introduced whose mechanical design actuation power transmission method well selection criteria discussed mechanical design section followed electrical circuits devices finally performance robot evaluated using test rig mechanism examines kinematical parameters arm could tracked approach
research analogical thinking devised several ways promoting abstract encoding base analogs thus rendering retrievable later encounters similar situations lacking surface similarities recent studies begun explore ways facilitating transfer retrieval time could facilitate retrieval distant analogs learned within contexts specially directed emphasize abstract structure studies demonstrate comparing target problem analogous problem helps students retrieve base analogs lack surface similarities devise portable ways enhancing analogical transfer experiment replicated kurtz loew enstein memory cognition target comparison procedure additional condition participants compared target nonanalogous problem attempting reach solution although comparing two analogous targets outperformed standard transfer condition promoting analogical transfer comparing nonanalogous problems yield transfer advantage based prior studies showed activity creating analogous problems initial encoding elicits abstract representation base analogs experiment assessed whether constructing second analogous target problem retrieval time helps participants retrieve superficially dissimilar base analogs predicted target invention increased retrieval distant sources experiments found association quality generated schemas probability retrieving distant base analog memory
advanced atherosclerotic changes often resist even aggressive treatment although basic mechanisms origin development known important steps process still waiting detailed explanation therefore addition already proved aggressive lowering ldl cholesterol appropriate timing atherosclerosis treatment essence revealing different stages atherosclerotic process less sensitive treatment primary importance however detection complicated several facts including exactly identifiable periods quiescence progression atherosclerotic process one populations study could add valuable information regarding problem women menopausal transition previously unsuccessful therapy hormone replacement therapy restudied focus time menopause supposed favorable women soon approximately less years menopause addition principle optimal timing intervention traditional cardiovascular risk factors especially lipids could also importance therefore menopausal transition could optimal period intervention women risk however approach proved evidence controlled prospective studies focused lifestyle pharmacological intervention
fractures distal section radius colles fractures occur earlier life osteoporotic fractures therefore interpreted warning signal later deleterious fractures vertebral bodies femoral neck past decade advent pqct allowed detailed architectural analysis distal radius automated time consuming estimation strength linear micro finite element analysis recently second generation pqct scanner xtremect scanco medical switzerland resolution beyond became available even refined biomechanical investigations vivo raises question biomechanical outcome variables compare original new scanner resolution accordingly aim work validate experimentally patient specific homogenized finite element analysis distal section human radius fast prediction colles fracture load based last generation pqct fourteen pairs fresh frozen forearms mean age scanned intact using high low resolution protocols correspond new original pqct systems forearm distal section radius dissected scanned tested experimentally compression failure assessment stiffness ultimate load linear nonlinear hfe models together linear micro finite element models generated based pqct reconstructions predict aforementioned mechanical properties sections precision errors short term reproducibility analyses measured based repeated scans sections calculated failure loads correlated strongly measured experiments accounting donor random factor nonlinear hfe provided marginal coefficient determination high resolution low resolution protocols linear hfe protocols linear predictions ultimate load similar protocols respectively nonlinear hfe strength computation led precision errors higher ones calculated based linear hfe linear protocols respectively computation fracture load nonlinear hfe demanded average cpu time times faster linear computation linear hfe took minutes study delivers extensive experimental numerical validation application accurate fast hfe diagnostic tool help identifying individuals may risk osteoporotic wrist fracture follow pharmacological treatments patients elsevier inc rights reserved
college construction management programs across nation integrating building information modelling bim curricula various forms specific priorities nevertheless common goal cultivate competent workforce possesses desired knowledge skills abilities ksas industry largely embracing bim study explores project based learning pbl pedagogy four year undergraduate curriculum special focus bim implementation sustainable design construction joint course project study examines pbl may improve critical student learning outcomes slos pertaining institutional assessment program accreditation requirements specifically students two upper division elective courses collaborated ongoing campus project roleplay would real project teams major project deliverables included developing leadership energy environmental design leed certification strategy bim project execution plan performing schematic design conducting performance simulation leed credit compliance documenting project information leed submittals formative summative assessments conducted pbl pedagogy joint course experience enhancing students understanding working knowledge bim implementation sustainability domain joint course project also provided instructors opportunities align course redesign program accreditation standards paper outlines strategies implementing managing joint course project shares various metrics tools adopted project evaluation results findings joint course project expected shed light competency based program assessment future bim curriculum innovation
purpose healthcare professionals provide services immediate long term aftermath traumatic events need understand nature frequency traumatic events lives women however research trauma exposure women recently begun assess events intimate partner sexual violence supported direct statistical comparison cross national cross cultural data purpose descriptive correlational study describe compare trauma exposure prevalence type community based samples women united states colombia hong kong design women recruited posted notices community health sites snowball sampling online advertisements life stressor checklist revised total score range used determine type prevalence trauma exposure data collected native language members research team methods descriptive statistics used summarize demographic characteristics trauma exposure total sample community based sample location location differences tested using fisher exact tests categorical measures general linear models pairwise posteriori least squares test continuous measures responses open ended questions translated categorized findings women total sample reported least one traumatic life event mean number traumatic life events per participant ranging although consistency commonly reported trauma exposures across locations rates specific events often differed conclusions historical political geographic cultural factors may explain differences trauma exposure among women four locations studied clinical relevance study offers relevant knowledge providers diverse locations provide services women experienced traumatic events provides evidence need future research enhance knowledge trauma exposure among women effects trauma women lives
stochastic petri nets widely used modeling analysis non functional properties critical systems state space explosion problem often inhibits numerical analysis models symbolic techniques exist explore discrete behavior even complex models block kronecker decomposition provides memory efficient representation stochastic behavior however combination techniques stochastic analysis approach straightforward paper integrate saturation based symbolic techniques decomposition based stochastic analysis methods saturation based exploration used build state space representation new algorithm introduced efficiently build block kronecker matrix representation used stochastic analysis algorithms measurements confirm presented combination two representations expand limits previous approaches
fusarium widely spread fungus affects small cereal grains mostly flowering thrives warm moist conditions fusarium head blight diminishes nutritional physical chemical qualities grains consequently lowers market value mycotoxins toxic secondary metabolites produced fungal infection process eliminated industrial processes milling baking malting ethanol production certain levels mycotoxins toxic effects humans livestock therefore fusarium monitoring extremely important avoid potential mycotoxin production optical techniques recognized one best ways assess batch samples fast non destructive way previous reviews fusarium assessment provided overview possible methods detection others list fusarium one among several known plant diseases provide applicable methods safety inspection food paper reviews current techniques grain quality assessment particularly thorough appraisal optical methods classification algorithms applied identify determine infection level fusarium spp hence work highlights latest literature concerning fusarium deoxynivalenol identification currently used methods determine levels infection
polycythemia vera blood disorder first expression may ischemic stroke stroke mechanism usually attributed hyperco agulability state blood stasis report case patient presenting recurrent ischemic stroke associated development large intracranial stenosis period month stenosis associated microembolic signals detected transcranial doppler one year later hematocrit control stenosis persisted microembolic signals disappeared discuss similar reports literature possible pathophysiological mechanism large vessel damage patients
supervisory control data acquisition scada systems monitor control industrial systems national importance including limited electric power grid oil gas refineries water supply sewage systems gas pipelines integral part nation critical infrastructure reliability availability systems extremely important scada systems running reliably changes hardware software typically avoided result many systems rely upon hardware software systems years even decades age time purpose cost optimization scada systems become increasingly reliant upon commercial shelf cots products many products known vulnerabilities expected patched replaced quite often mitigate potential attacks however frequent patches updates often unfeasible scada system requirements reliability availability may outweigh potential benefits additional security issue order enable remote system management scada systems becoming increasingly connected directly corporate networks well internet thus making easier adversary connect system order exploit known vulnerabilities moving target defense mtd security approach used many common computer systems help make less easily compromised mtd seeks provide additional protection protected programs even programs known vulnerabilities seek fix particular software vulnerability instead seeks make vulnerability difficult exploit security solutions elaborated common computer systems networks frequent software patching might applicable scada systems due specific requirements constraints however much academic discussion applying moving target defenses scada systems analysed several different mtd techniques suitability defense various components scada systems determination several mtd approaches feasible use scada systems
quality essential commodity water compromised contaminants originating anthropogenic sources industrial activities agriculture etc water scarcity severe droughts many regions world also represent significant challenge availability resource domestic rainwater harvesting involves collection storage water rooftops diverse surfaces successfully implemented worldwide sustainable water supplement review focuses chemical microbial qualities domestic rainwater harvesting particular focus sources chemical pollution major pathogens associated water source incidences disease linked consumption utilization harvested rainwater also discussed addition various procedures methods used disinfection treatment harvested rainwater implementation filter systems activated carbon slow sand filtration etc heat treatment chlorination among others also presented
nascent field nutritional psychiatry offers much promise addressing large disease burden associated mental disorders consistent evidence base observational literature confirms quality individuals diets related risk common mental disorders depression case across countries age groups moreover new intervention studies implementing dietary changes suggest promise prevention treatment depression concurrently data point utility selected nutraceuticals adjunctive treatments mental disorders monotherapies conditions adhd finally new studies focused understanding biological pathways mediate observed relationships diet nutrition mental health pointing immune system oxidative biology brain plasticity microbiome gut brain axis key targets nutritional interventions hand field currently limited lack data methodological issues heterogeneity residual confounding measurement error challenges measuring ensuring dietary adherence intervention studies key challenges field replicate refine scale promising clinical population level dietary strategies identify clear set biological pathways targets mediate identified associations conduct scientifically rigorous nutraceutical psychobiotic interventions also examine predictors treatment response conduct observational experimental studies psychosis focused dietary related risk factors treatments continue advocate policy change improve food environment population level author published elsevier open access article license http creativecommons org licenses
resource consumption accounting rca major innovation manufacturing management accounting combines activity based costing marginal cost elasticity germany rca used analysis management production basis budget project provide evidence sub projects sub contract
hip fractures high incidence rates many current groups associated high morbidity mortality considerable expenditure although hip fractures associated significant traumatic events occur age many hip fractures occur older adults date hip fractures reported archaeological skeletal material number hypotheses suggested research presents comprehensive assessment hip fractures archaeological bone adult years skeletons eight urban post medieval sites england dating centuries recorded contemporary medical texts reviewed adult sample included males females well persons undetermined sex ways classifying describing fractures clinical literature reviewed methodology applicable paleopathology determined sample fractures femoral neck intertrochanteric area nine males four females two individuals undetermined sex numbers fractures males interesting likely represent examples accidental trauma well osteoporosis related fractures latter receiving growing awareness recent clinical literature overall age related trend individuals aged years fractures age categories underlying osteoporosis potentially complicating factor five individuals likely associated vitamin deficiency osteomalacia metastatic neoplastic condition two cases fractures occurring close time death healed fractures observed indicating risk mortality following trauma consistent across century sample skeletal historical evidence presented study indicate impact hip fracture injuries varied survival likely linked fracture type copyright john wiley sons ltd
background aim asia pacific cost major concern peginterferon plus ribavirin often remain standard care chronic hepatitis chc treatment direct acting antivirals daas commonly recommended retreatment newer daas achieve sustained virological response svr nearly pan genotypic coverage highly effective daas aimed investigate desirable cost range highly effective daas using hong kong example methods markov modeling performed using reference strategy cost effectiveness highly effective daas compared sofosbuvir first line rescue boceprevir therapies year old genotype hepatitis virus hcv infected treatment naive patient metavir used base case scenario reflect commonest hcv genotype hong kong results use would incur lifetime cost effectiveness quality adjusted life year qaly sofosbuvir first line treatment dominated regimes sofosbuvir rescue therapy used drug cost highly effective daas set cost effectiveness ratio cer qaly compared regions boceprevir still used first line therapy desirable drug cost highly effective daas would achieve cer qaly conclusions desirable costs highly effective daas would sofosbuvir rescue therapy used boceprevir therapy used
extensive diagnostic therapeutic interventions particularly problematic dangerous diabetic patients metabolic derangement cardiovascular renal neurological psychiatric thromboembolic complications uncommon additionally cases inadequate preoperative metabolic adjustment perioperative complications wound healing disorders general infections possible multimorbidity necessary polypharmacy early hospital discharge insufficient training physicians nursing personnel complex disease financial pressures inadequate preoperative preparation patients elective interventions essential reasons average frequency perioperative postoperative complications diabetic patients care adults disease discussed preoperative period discharge detailed recommendations given perioperative management antidiabetic drugs
paper presents novel technique analysis looped linear time invariant electric circuits approach works time laplace domains type elements could hence incorporated circuit elements partitioned twofold classes basic circuit subsidiaries basic circuit spanning tree network subsidiaries include circuit elements hypothetically removed looped electric circuit open loops subsidiaries include suit passive elements might even make interconnected circuit circuit governing equations flow energy conservation manipulated branch currents subsidiaries branch voltages basic circuit considered independent variables calculate passive element properties impedance passive elements directly contrast existing methods technique tailored circuit analysis reverse manner complement conventional circuit analysis techniques method taught undergraduate program offer students alternative tool circuit analysis
arid semi arid areas artificial recharge key technology groundwater resources management reliable estimate artificial recharge necessary sustainable development several methods available estimate artificial recharge however require field data model parameters thus limiting applications overcome limitation presented analytical method estimate artificial recharge monitoring water release piezometer analysing controlling factors artificial recharge hill dam tunisia total measurements water flow streambed recorded gauging stations analysed results indicated average infiltration velocity ranged infiltration index varied pearson correlation coefficient analysis shows infiltration index stream gradient thickness unsaturated zone number infiltration pond stream geometry water flow rate found main factors determining infiltration high correlation coefficients number infiltration pond stream geometry mean number infiltration pond stream geometry influential factors time variations groundwater level used analyze recharge effects piezometry aquifer analysis showed artificial recharge water table increased rate increase limited area surrounding recharge site based results study building infiltration ponds along streambed improving potential rainwater harvesting study area recommended
attack graphs show possible paths attacker use intrude target network gain privileges series vulnerability exploits computation attack graphs suffers state explosion problem occurring notably number vulnerabilities target network grows large parallel computation attack graphs utilized attenuate problem employed online network security evaluation computation attack graphs triggered correlated intrusion alerts received sensors scattered throughout target network cases distributed computation attack graphs becomes valuable article introduces parallel distributed memory based algorithm builds vulnerability based attack graphs distributed multi agent platform virtual shared memory abstraction proposed used platform whose memory pages initialized partitioning network reachability information demonstrate feasibility parallel distributed computation attack graphs show even small degree parallelism effectively speed generation process problem size grows also introduce rich attack template network model order form chains vulnerability exploits attack graphs precisely
although construction industry shown significant improvements safety performance past years falls still leading cause fatalities serious injuries previous studies focused identifying factors affecting risk falls remained silent investigating evidential relationships among factors better prevent fall accidents research proposes bayesian network based approach diagnose accident risk working heights proposed approach consists conceptual generic model protocol assessing risk falls computational module generic model developed basis extensive review evaluation causal factors leading falls computational module developed basis bayes rule inference customize model input job site characteristics results proposed approach provide probabilities associated different states safety risk additionally sensitivity analysis allows practitioners identify appropriate preventive actions safety strategies reduce risk fall proposed approach verified tested construction operation condo hotel project study contributes construction safety body knowledge providing effective quantitative risk assessment tool predict safety risk falls heights researchers practitioners may customize model assess benchmark fall risk different operations construction industry
sustainable construction construction method beginning gain traction among indonesian contractors dearth research knowledge socialization strategic support field many obstacles towards masse adoption indonesia applied effectively become part strategic method concept sustainable construction primarily emphasizes wise use resources primarily natural resources thereby systematically guaranteeing fulfillment future needs however use recycled materials still hampered difficulty field implementation attested low scores attained green building certification study analyze strategies needed support sustainable construction relation supply chain management materials implemented well indonesia whereas highest impact contributing effectiveness sustainable construction aim study analyze supply chain performance materials construction projects measurement used supply chain operations reference scor model perfect order fulfillment overall value risk key performance indicator kpi result study percentage material could used management supply chain kpi fulfilled perfect order fulfillment use material complete support sustainable construction authors published elsevier ltd
mechanics urine transport renal pelvis bladder great interest urologists knowledge different physical variables interrelationship physiologic movements pathologies help better diagnosis treatment objective chapter show physics principles relevant basic relations urine transport bring clinical world explain movement urine peristalsis ureteral obstruction ureter stent explanation based two tools used bioengineering theoretical analysis theory continuous media ffluid mechanics computational simulation offers practical solution scenario moreover review contributions bioengineering field urology physical simulation additive subtractive manufacturing techniques finally list current limitations tools technological development lines future projection conclusions chapter aim help urologists understand important concepts bioengineering promoting multidisciplinary cooperation offer complementary tools help diagnosis treatment diseases
past two decades growing awareness sport may positive experience children example know children experience sexual abuse context organised sport offences often committed trusted adults including coaches club officials however less attention given physical abuse child athletes paper presents study explored children experiences organised sport recounted young people ages years australia study explored experience child physical abuse organised sport including violence overtraining training injured mixed methods research design produced survey responses depth interviews young adults respondents reported positive impact participating sport development third respondents also described experiences overtraining forced train injured direct physical violence drawing upon thematic analysis qualitative data conceptual model developed presented assist understanding dynamic secrecy may facilitate ongoing physical harm children context
mirror neurons mns fascinating class cells originally discovered ventral premotor cortex pmv subsequently inferior parietal lobule ipl macaque become active execution observation actions review first highlight mounting evidence indicating mirroring others actions engages broad system reciprocally connected cortical areas extends well beyond classical ipl pmv circuit might even include subcortical regions basal ganglia present recent findings supporting idea observation one actions might play role ontogenetic origin tuning mns retains particular relevance within adult system finally propose cortical subcortical mechanisms exist decouple activity motor output order render exploitable high order perceptual cognitive even social functions findings reviewed provide original framework envisaging main challenges experimental directions future neurophysiological neuroanatomical studies monkey system
diverticulosis defined presence diverticula due herniation mucosa muscularis mucosa muscularis propria sites vascular penetration colon asymptomatic vast majority affected global differences distribution western industrialized societies common site left colon asia right sided diverticulosis predominates whilst present general population comers endoscopy seen aged years diverticular disease defined clinically significant symptomatic diverticulosis may absence macroscopically overt colitis true diverticulitis macroscopic inflammation diverticula related acute chronic complications whilst overall diverticulitis affects diverticulosis younger patients aged years peaks diverticulosis one common chronic diseases yet research field pathogenesis lagged behind common conditions diabetes mellitus however last decade major advances taxonomy used relate patients outcome treatment medicine surgery shown association age diet drugs smoking genetic studies shown familial association specific gene tnfsf may predict severity disease role microbiome explored microbial metabolomic signatures also important predicting disease severity diverticulosis chronic disease shown mucosal pathology subtle chronic inflammation present asymptomatic diverticulosis inflammation may lead muscular hypertrophy enteric nerve remodeling disordered motility diverticulitis quality life instrument shows condition impacts markedly patients well prevention amelioration complications aim treatment research attain goal needed
article examines whether employment outcomes exoffenders associated employers subjective belief redeemability mediated exoffenders objective desistance signals online factorial vignette survey completed employers examined hiring decisions context exoffender job applicants ols regression serial multiple mediation analyses revealed belief redeemability desistance signals positively significantly predicted employers hiring decisions well exoffenders objective desistance signals mediated association belief redeemability employment outcomes findings highlight importance exoffenders effectively communicate desistance crime employers endeavors obtain employment
extensive abnormal interactions among microglia astrocytes neurons cns observed proteinopathic neurodegenerative dementias elderly thesemulticellular interactions initiated insoluble tangles phosphorylated tau protein plaques amyloid peptides research focused neurotoxic proteins much less known pathogenic roles responding resident recruited neural cells principal interactions among major sets cns cells herein considered several levels relation cellular phenotypic alterations mechanisms cellular communication extent involvement pathogenesis alzheimer disease related proteinopathic dementias remains determined abnormal neurocellular phenomena primary events sufficiently contributory neurodegeneration useful targets therapy senile dementias goetzl miller multicellular hypothesis pathogenesis alzheimer disease
removal dye industrial wastewater one important subjects water pollution regulation successive adsorption desorption cycles basic dye methylene blue internal almond shell olive stone rye straw investigated using fixed bed column experiments study adsorption capacity remove adsorbents regeneration efficiency adsorption breakthrough curves predicted thomas model yoon nelson model wolborska model modified dose response model using nonlinear regressive analysis adsorption capacity values obtained model compared experimental capacity noting error ias respectively errors minimized second cycle respectively results show modified dose response model suitable description breakthrough curves three adsorbents first cycle ias presents highest adsorption capacity best regeneration efficiency conversely presents lower adsorption capacity whereas hardest regenerate
family style dining fsd caregivers encouraged sit children table support promote facilitate conversations fsd considered best practice child care encouraged many early childhood agencies however current research documenting effects fsd mealtime interactions preschool environment purpose current study examine effects fsd social interactions preschool children mealtime subsequent changes rate teacher directives praise statements results demonstrated increases rates initiations target children fsd implemented however increases across children modest also teachers rates directives impacted use fsd teachers rates directives average using using fsd
genus enterovirus poliovirus coxsackievirus rhinovirus picornaviridae family positive strand rna viruses includes many important pathogens linked range acute chronic diseases approved antiviral therapy available targeting step life cycle highly conserved provides attractive strategy developing broad range inhibitors enterovirus infection step currently explored target development antivirals formation replication organelles support replication viral genome build replication organelles enteroviruses rewire cellular machinery hijack lipid homeostasis pathways example enteroviruses exploit pikiiii beta pip osbp pathway direct cholesterol replication organelles uncover ttp known enterovirus replication inhibitor acts pikiiii pip osbp pathway directly inhibiting osbp activity however despite shared mechanism established osbp inhibitors itraconazole osw identify number notable differences compounds antiviral activity ttp extends viruses require osbp namely picornavirus encephalomyocarditis virus flavivirus hepatitis virus authors published elsevier open access article license
objectives television viewing associated greater subsequent attention problems children studies examined possibility similar association video games attention problems none used longitudinal design methods sample middle childhood participants assessed month period parent child reported television video game exposure well teacher reported attention problems another sample late adolescent early adult participants provided self reports television exposure video game exposure attention problems results exposure television video games associated greater attention problems association television video games attention problems middle childhood sample remained significant earlier attention problems gender statistically controlled associations screen media attention problems similar across media type television video games age middle childhood late adolescent early adult conclusions viewing television playing video games associated increased subsequent attention problems childhood seems similar association among television video games attention problems exists late adolescence early adulthood research potential risk factors attention problems expanded include video games addition television pediatrics
multi wavelength generation system using optical spin within modified add drop optical filter known panda ring resonator molecular transport network security proposed using dark bright soliton pair control optical capsules constructed applied securely transport trapped molecules within network advantage dark bright soliton pair components securely propagate long distance without electromagnetic interference operation optical intensity panda ring resonator fed gold nano antenna surface plasmon oscillation soliton pair metallic waveguide established
chronic rhinosinusitis nasal polyps crswnp multifactorial disease pathogenesis crswnp remains unclear study designed investigate role inflammation staphylococcus aureus enterotoxin disease study included total patients crswnp controls serum phadiatop assay conducted detect atopy status serum eosinophil cationic protein ecp total immunoglobulin levels determined using elisa sea seb total ige ecp myeloperoxidase mpo levels nasal tissue supernatant measured using elisa results indicated patients systemic allergies basis ecp mpo ratio patients divided eosinophilic crswnp group non eosinophilic crswnp group total ecp mpo ratio notable bias toward neutrophilic inflammation supernatant ecp mpo levels elevated crswnp group compared control group significant difference serum total ige ecp levels observed crswnp control groups addition non eosinophilic eosinophilic crswnp groups showed significant elevations supernatant total ige sea seb levels compared control group thus may concluded allergy common pathogenesis crswnp neutrophilic inflammation present chinese crswnp patients additionally local indicators reflect inflammatory status accurately serum indicators ses may act infection factor rather superantigen chinese non eosinophilic crswnp patients thus long term antibiotic therapy may option chinese non eosinophilic crswnp patients
delay discounting future oriented decision making process refers whether one willing forego smaller sooner reward sake larger later reward assessed using hypothetical tasks involve choices hypothetical rewards varying amounts delay periods days years experiential tasks involve receiving actual rewards real time delay periods seconds minutes initial studies schizophrenia used hypothetical tasks mixed finding either elevated normal levels one hundred thirty one outpatients schizophrenia healthy controls completed hypothetical experiential tasks involving monetary rewards schizophrenia group retested weeks although groups showed qualitatively similar hyperbolic discounting functions tasks showed quantitative difference schizophrenia showed higher controls experiential task normal hypothetical task pattern attributable range potential confounds including smoking status substance use disorder status neurocognition also attributable differences test retest reliability good tasks schizophrenia group robust pattern altered experiential normal hypothetical task performance points key factors may contribute impaired disorder may include increased valuation small large monetary rewards hypersensitivity costs associated waiting inactively rewards
cell infiltration metastatic melanoma may useful biomarker prediction prognosis response therapy heterogeneous distribution cells within single tumor across different tumors within single patient may complicate quantification infiltration however impact heterogeneity quantified sufficiently address assessed intratumoral heterogeneity cell counts well intertumoral heterogeneity synchronous metachronous metastases tissue microarray containing melanoma metastases patients density cells per sample determined immunohistochemistry mean density coefficient variation calculated tumor rates discordant values determined counts varied widely among different core samples tumors average coefficient variation confidence interval discordance occurring tumors densities similar among pairs simultaneous tumors however significant changes densities observed among pairs metachronous tumors cell density well represented single diameter sample differences cell counts observed clinical trials pretreatment post treatment specimens may explained spatial temporal heterogeneity distribution especially assessed samples small sufficiently large biopsy one several synchronous tumors may representative cell infiltration patient disease copyright wolters kluwer health inc rights reserved
alya multi physics simulation code developed barcelona supercomputing center bsc inception alya code designed using advanced high performance computing programming techniques solve coupled problems supercomputers efficiently target domain engineering particular features complex geometries unstructured meshes coupled multi physics exotic coupling schemes physical models ill posed problems flexibility needs rapidly including new models etc since beginnings alya scaled well increasing number processors solving single physics problems fluid mechanics solid mechanics acoustics etc time made concerted effort maintain even improve scalability multi physics problems poses challenges multiple fronts including numerical models parallel implementation physical coupling models algorithms solution schemes meshing process etc paper introduce alya main features focus particularly solvers present alya performance processors blue waters ncsa supercomputer selected multi physics tests representative engineering world tests incompressible flow human respiratory system low mach combustion problem kiln furnace coupled electro mechanical contraction heart show scalability plots cases discuss aspects simulations including solver convergence elsevier rights reserved
aim study aimed explore association maternal communication style controlling autonomy supportive adolescents motivation change alcohol use well intervening role autonomy relatedness needs frustration coping responses oppositional defiance submission association methods vignette based study conducted adolescents age years randomly assigned controlling condition describing maternal reaction alcohol use episode adolescents reported upon experienced need frustration coping responses motivation change alcohol use findings results indicated adolescents controlling condition felt frustrated needs autonomy relatedness adolescents confronted reaction adolescents experienced frustration regarding autonomy need coped submitting maternal request turn predicted greater motivation change alcohol use however experienced frustration regarding relatedness need engaged oppositional defiance request turn predicted lower motivation change alcohol use conclusions results suggest controlling maternal communication style relates two distinct processes opposing effects adolescents motivation change alcohol use
novel polarization insensitive metasurface angular stability ultra broadband ghz backscatter radar cross section rcs reduction investigated proposed metasurface composed carefully arranged unit cells spatially varied dimension diffuse reflection uniformly avoid reflection specular direction proposed metasurface sample fabricated tested validate rcs reduction behavior predicted full wave simulation software ansys hfss rcs reduction within entire band observed indicating metasurface may potentially applied future stealth technology
neuroleptic drug molindone hydrochloride dopamine receptor antagonist late stage development treatment impulsive aggression children adolescents attention deficient hyperactivity disorder adhd new indication drug would expand target population include younger patients therefore toxicity assessments juvenile animals undertaken order determine susceptibility differences age group adult rats adult rats administered molindone oral gavage weeks dose levels day juvenile rats dosed weeks oral gavage dose levels day standard toxicological assessments made using relevant study designs consultation fda treatment related elevation serum cholesterol triglycerides decreases glucose levels observed age groups organ weight changes included increases liver adrenal gland seminal vesicles prostate weights decreases uterine weights also observed adult females exposed top two doses sufficient exposure juveniles sexual maturity parameters secondary decreased body weights observed reversed conclusion adverse effects noted reproductive tissues adults attributed hyperprolactinemia changes considered relevant humans due species differences hormonal regulation reproduction whole remarkable differences toxicity profile drug two age groups
immunodeficient mice engrafted functional human cells tissues humanized mice become increasingly important small preclinical animal models study human diseases since description immunodeficient mice bearing mutations receptor common gamma chain ilrg null early investigators able engraft murine recipients human hematopoietic stem cells develop functional human immune systems mice also engrafted human tissues islets liver skin solid hematologic cancers humanized mice permitting significant progress studies human infectious disease cancer regenerative medicine graft versus host disease allergies immunity ultimately use humanized mice may lead implementation truly personalized medicine clinic review discusses recent progress development use humanized mice highlights utility study human diseases
impact intercultural workplace relationships local employees scarcely investigated hospitality paper adopts contact hypothesis perspective order explore ways intercultural encounters foreign local hospitality employees influence latter sociocultural organizational terms conceptual model developed tested within cypriot hospitality industry analyzed using structural equation modeling findings support contact hypothesis prior attitudes towards ethnically different influence development intercultural workplace relationships turn influence local employees wider attitudes towards foreigners furthermore importance fair treatment respect work stressed mediate relationship intercultural workplace relationships affective commitment implications hospitality organizations derived suggestions provided elsevier ltd rights reserved
objective objective study analyze impact overall survival addition postoperative radiation without chemotherapy esophagectomy using large hospital based dataset background previous retrospective studies suggested advantage postoperative chemoradiation surgery alone although prospective data lacking methods national cancer data base queried select patients diagnosed stage esophageal carcinoma squamous cell adenocarcinoma treated definitive esophagectomy postoperative radiation chemotherapy analyzed using kaplan meier method compared using log rank test multivariate cox regression analysis used identify covariates associated results patients selected received postoperative radiation patients receiving radiation also received sequential concomitant chemotherapy entire cohort postoperative radiation associated statistically significant modest absolute improvement survival hazard ratio subgroup analysis postoperative radiation associated improved patients node positive disease positive margins chemotherapy usage incorporated sequential chemotherapy associated best survival multivariate analysis revealed addition chemotherapy radiation therapy whether sequentially concurrently strong prognostic factor conclusions hospital based study addition postoperative chemoradiation either sequentially concomitantly esophagectomy associated improved patients node positive disease positive margins
parkinson disease patients higher risk malnutrition prevalence estimated patients reported risk malnutrition date clear explanation malnutrition patients aim study determine prevalence malnutrition analyze factors influence appearance mini nutritional assessment mna used determine normal nutritional status risk malnutrition already malnourished status unified parkinson disease rating scale updrs parts iii hoehn yahr scale scale beck depression inventory bdi mini mental state examination mmse questionnaire impulsive compulsive disorders parkinson disease rating scale eating part quip mini nutritional assessment mna used evaluate factors affecting patient nutritional status patients risk malnutrition already malnourished age scale updrs part iii periods depression influence negatively mna patients periods rigor dominant thyroid gland hormone therapy related malnutrition patients normal nutritional status used ropinirole often pramipexole factors affecting nutritional status age motor symptoms stage severity states rigidity dominant type states thyroid hormone replacement therapy ropinirole exhibited possible protective effect malnutrition elsevier rights reserved
paper describes fuzzy control methodology continuous passive motion equipment cpm methodology combines fields artificial intelligence fuzzy controller development control engineering joining optimization mechanism movement closed loop control following uml marte profile used modeling methodology based system input output set defined rules model plant dynamic behavior control algorithm developed test analysis laboratory prototype experiments demonstrates methodology applicability scenarios time constraints related position feedback stepper motor motor satisfactory
shift operator finite difference time domain fdtd method developed study stealth technology inhomogeneous magnetized plasma paper high accuracy efficiency method verified computing reflection transmission coefficients electromagnetic wave collisional magnetized plasma slab one dimension stealth effect radar targets covered epstein distribution inhomogeneous magnetized plasma studied results show stealth effect radar targets covered epstein distribution inhomogeneous magnetized plasma better radar targets covered homogeneous magnetized plasma elsevier gmbh rights reserved
design computer assisted decision cad systems different biomedical imaging scenarios challenging task computer vision sometimes challenge attributed image acquisition mechanisms since lack control cameras create different visualizations imaging site different rotation scaling illumination parameters requirement get consistent diagnosis cad systems moreover images acquired different sites specific colors making use standard color spaces highly redundant paper propose tackle issues introducing novel region based texture color descriptors proposed texture features based usage analytic gabor filters compensation illumination variations followed calculation first second order statistics filter responses making invariant using trivial mathematical operators proposed color features obtained compensating illumination variations images using homomorphic filtering followed bag words approach obtain typical colors images proposed features used identification cancer images two distinct imaging modalities gastroenterology dermoscopy experiments demonstrate proposed descriptors compares favorably several state art methods elucidating effectiveness adapted features image characterization
perineal streptococcal dermatitis psd largely known caused group beta hemolytic streptococcus gas would like bring cases non gas psd attention dermatologists implications workup therapy report pediatric cases psd caused gas caused group beta hemolytic streptococcus gbs associated group hemolytic streptococcus gcs gbs gcs rarely reported pediatric cases psd literature non gas psd reviewed additionally revealed several instances psd caused group beta hemolytic streptococcus ggs staphylococcus aureus gbs gcs ggs aureus significant causes psd consider particularly among adult patients based encountered cases literature using rapid antigen tests expedite diagnosis gas recommend supplementing lesional swab bacterial culture sensitivity rapid antigen test detect non gas organisms therapy tailored microbiologic cause
objective nowadays smartphone overuse become social medical concern diagnosis treatment clinicians use self report information report data often match actual usage pattern paper examines similarity variance smartphone usage patterns measured data self reported data methods together self reported data real usage log data collected college students metropolitan region northeast asia using android smartphone monitoring application developed authors results unconscious users underestimate usage time spite use actual usage messengers used application regardless self report significant preference sns applications observed addict group actual hourly pattern consistent reported one college students use afternoon free time use pcs significant difference hourly pattern observed measured self report conclusion result shows significant cognitive bias actual usage patterns exists self report smartphone addictions clinicians recommended utilize measurement tools diagnosis treatment smartphone overusing subjects
within last decades performance concrete significantly improved applying different kinds micro nanoparticles applying analytical methods fundamental research disciplines used construction materials atomic force microscopy one prominent result ultra high performance concrete uhpc steel like compressive strength allows slender nevertheless long lasting thus sustainable concrete structures top several research projects performed university kassel contribution likes review aim making concrete impervious ceramic like acid resistant multifunctional smart material added values changing nano microstructure applying reactive coatings ability degenerate air pollutants elsevier ltd rights reserved
recent decades site layout known one challenging problems among researchers field construction management since problem validated complete problem exact method find best solution particular medium large scale problems several researches conducted solving problem using meta heuristics however new meta heuristics may lead accurate solutions less computational time research two new meta heuristics called cbo ecbo employed solve construction site layout problem results show capability solving kind problem two case examples solved show applicability performance proposed methods
impaired insight illness imp ins common among individuals schizophrenia spectrum disorders ssd contributing medication nonadherence poor clinical outcomes caloric vestibular simulation cvs typically used assess peripheral vestibular system function left cold cvs also transiently effective treatment imp ins hemineglect secondary right brain hemisphere stroke possibly imp ins mood stabilization patients ssd participants ssd moderate severe imp ins participated exploratory double blind crossover randomized controlled study effects cvs imp ins participants sequentially received experimental conditions left cold degrees right cold body temperature sham cvs random order repeated measures anova performed compare changes imp ins mood positive symptom severity pre min post cvs significant interaction found cvs condition time body temperature nystagmus peak slow phase velocity pspv imp ins indicating single session left cold cvs transiently improved imp ins right cold cvs may worsened imp ins particularly participants greater vestibular reactivity higher pspv body temperature cvs procedure effectiveness attributed stimulation underactive right hemisphere circuits via vestibular nuclei projections contralateral hemisphere
portable real time facial recognition system able play personalized music based identified person preferences developed system called portable facial recognition jukebox using fisherfaces frj raspberry used hardware platform relatively low cost ease use system uses opencv open source library implement computer vision fisherfaces facial recognition algorithms uses simple directmedia layer sdl library playing sound files frj crossplatform run windows linux operating systems source code written accuracy recognition program reach controlled lighting distance conditions user able train different people many fit gui implemented raspberry system able image capture facial recognition average time
background oral bisphosphonates prescribed widely osteoporosis patients bisphosphonate related osteonecrosis jaw bronj reported major complication little information minor complications objective retrospective study describes post operative complications bronj associated dental extractions patients oral compares outcomes patients oral methods study period ending december prior introduction protocols minimising risks related extractions patients therapy records patients aged years underwent extractions period sydney dental hospital examined post operative complications analysed results participants identified oral therapy available number available files based retrospectively records participants underwent extractions two year period oral group complications compared non oral group relationship remained significant even adjusting age gender operator type site procedure delayed healing exposed alveolar bone required intervention common complications group conclusion prevalence minor post operative complications among participants significantly higher non participants nature complications range pathology familiar treatable general dentist
objective study find optimal combination factors used process wastewater treatment collect suspended rubber content disc cleaning process factors include amount grass waiting time required rubber coagulate study conducted using two sets experiments one find deterministic optimal amount grass waiting time one find whether practical use fiber optic sensor tool indicate sufficient amount grass required results experiments show using fiber optic sensor requires greater amount grass deterministic method since objective function sensor model maximize light intensity wastewater objective function deterministic model maximize percentage achieved rubber contents
propose distributed local search dls algorithm parallel formulation local search procedure attempt follow spirit standard local search metaheuristics applications different operators solution diversification possible similar way variable neighborhood search formulate general energy function equivalent elastic image matching problems specific example application stereo matching experimental results show gpu implementation dls seems method provides increasing acceleration factor instance size augments among eight tested energy minimization algorithms
quantitative detection glucose important issue food industry various biotechnological processes medication metabolic disorders herein reported detection method based doped cdte zns modified nanosensor rapid sensitive detection glucose levels human biological fluids blood urine strategy doped cdte zns quantum dots qds designed direct measurement glucose fluorescence doped cdte zns qds sensitive hydrogen peroxide catalytic oxidation glucose glucose oxidase gox produces extensively quenched qds experimental results showed decrease qds proportional concentration glucose within range detection limit optimized experimental conditions glucose blood urine samples effectively detected strategy comparison commercialized glucose meter indicated proposed glucose assay system simple sensitive also reliable suitable practical application high sensitivity versatility portability high throughput low cost glucose sensor implied potential point care clinical diagnosis diabetes fields elsevier rights reserved
increased brain volume consistent finding young children autism spectrum disorders asd however regional specificity developmental course abnormal brain structure less clear small sample sizes particularly among voxel based morphometry vbm investigations likely contribute difficulty recently established large scale neuroimaging data repositories helped clarify neuroanatomy neuropsychiatric disorders schizophrenia may prove useful asd structural brain images autism brain imaging database exchange abide contains participants analyzing using dartel vbm investigate total brain tissue volumes regional brain structure abnormalities asd two overlapping cohorts analyzed subjects cohort included individuals usable mri data matched samples cohort comprised asd individuals matched within site age sex total brain grey matter volumes enlarged approximately asd however effect reached statistical significance subjects cohort within subjects cohort vbm analysis revealed enlargement left anterior superior temporal gyrus asd significant regional changes detected matched samples cohort non significant reduction correlation tbv asd compared brain structure abnormalities asd individuals age older consists subtle increase total brain volume due enlargement grey matter little evidence regionally specific effects
several researchers reported instructing participants imagine items using deese roediger mcdermott drm paradigm lowers false memory rates foley wozniak gillum however researchers found imagery always lower false memory rates robin investigators examined effects imagery manipulation semantic phonological lists present study presented participants semantic phonological drm lists followed free recall test final recognition test participants received instructions imagine list items study phase facilitate memory others simply told remember list items imagery instructions enhanced correct memories suggested trend decreased false memories test type list type interaction also emerged phonological lists eliciting higher false memories recall semantic lists eliciting higher false memories recognition directions future research discussed
aim study evaluate rate power doppler ultrasound pdus abnormalities entheseal sites patients early psoriatic arthritis psa traditional biologic dmards compare pdus findings clinical examination psa patients early disease traditional biologic dmards consecutively enrolled study patients underwent pdus examination following bilateral entheseal sites common extensor tendon insertion lateral humeral epicondyle quadriceps tendon insertion superior pole patella patellar tendon insertion tibial tuberosity medial collateral ligament proximal insertion achilles tendon insertion calcaneus leeds enthesitis index lei used assess clinical entheseal involvement twenty one early psa patients completed clinical pdus examinations clinical entheseal involvement found pdus abnormalities early psa patients achilles tendon insertion site major entheseal abnormalities active power doppler positive entheseal lesions found patients lateral humeral epicondyle quadriceps tendon patellar tendon insertions achilles tendon insertions respectively concordance clinical lei pdus poor present study confirms pdus allows detecting structural inflammatory abnormalities enthesis early psa patients study shows early disease active abnormalities seem low prevalence
cascade air source heat pump water heater suitable provide high temperature water wide range outdoor air temperature previous studies focused operating characteristics cascade heat pump system performance improvement selection optimal immediate temperature however reported studies control strategies cascade heat pump may identified paper proposed control strategy cascade air source heat pump water heater adjust load variation principle two stage compression ratio approximately used determine intermediate pressure intermediate pressure degree superheat evaporating temperature regulated compressor electronic expansion valves eev evaporator fan low temperature cycle respectively proportion integration differentiation pid controller proportional controller control strategy experimentally tested wide operational range cascade air source heat pump water heater results showed controller developed successfully helped realize control intermediate pressure evaporating temperature terms control accuracy sensitivity elsevier ltd rights reserved
objective investigate possible associations parkinson disease polymorphism depression related genes alpha synuclein snca gene methods consecutive series patients divided depression without patients genotyped four single nucleotide polymorphisms snps four genes previously associated depression well four snps associated snca gene results patients depression univariate analysis revealed significant differences two groups minor allele frequency snp slca gene well frequencies genotypes minor alleles tph gene genotype genotype conclusions among patients depression associated polymorphism previously linked depression results may help clarify pathogenesis depression elsevier rights reserved
paper concerned new proof existence weak solution navier stokes problem based fixed point theory results weak topology setting without assumption smallness data
periosteum serves bone bounding membrane exhibits hallmarks semipermeable epithelial barrier membranes contains mechanically sensitive progenitor cells capable generating bone current paucity data regarding periosteum permeability bidirectional transport properties provided impetus current study ovine femur tibia samples periosteum hydraulic permeability coefficient calculated using darcy law custom designed permeability tester apply controlled volumetric flow phosphate buffered saline periosteum samples based data ovine periosteum demonstrates mechanically responsive directionally dependent anisotropic permeability properties baseline flow rates comparable interstitial fluid flow permeability low exhibit anisotropy contrast high flow rates comparable prevailing traumatic injury femoral periosteum exhibits order magnitude higher permeability compared baseline flow rates addition high flow rates permeability exhibits significant directional dependence permeability higher bone muscle direction vice versa furthermore compared periosteum intrinsic tension pre stress maintained free relaxation tibial periosteum resection significantly increases permeability flow directions hence structure mechanical stress state periosteum influences role bone bounding membrane periods homeostasis periosteum may serve barrier membrane outer surface bone allowing equal albeit low quiescent molecular communication tissue compartments including bone muscle contrast increases pressure baseline flow rates within periosteum resulting injury trauma disease may result significant increase periosteum permeability consequently increased molecular communication tissue compartments elucidation periosteum permeability properties key understanding periosteal mechanobiology bone health healing well elucidate periosteum structure function smart biomaterial allows bidirectional mechanically responsive fluid transport american society bone mineral research
purpose review asthma due cleaning products known years interest topic still large number cleaning workers respiratory problems review sought highlight recent findings relationship exposure cleaning products asthma summarize specific literature published recent findings women confirmed workers exposed cleaning products higher frequency men work related respiratory symptoms diseases many cases asthma due cleaning products occur healthcare occupations increased risk asthma shown related number years job early life disadvantage recent evidence suggests predisposition adult onset asthma may related interaction genes occupational exposure low molecular weight agents irritants evidence irritant mechanism common although several case reports showed animmunologic mechanism disinfectants amine compounds aldehydes fragrances summary review updated recent findings epidemiology cleaning agents mechanism prevention asthma due cleaning agents article provides new information level exposure still high professional cleaners even domestic cleaners frequency asthma professional domestic cleaners irritant mechanism common although immunological mechanism possible especially healthcare workers exposed disinfectants
present preliminary results work low cost multi user immersive virtual reality system enables collaborative experiences large virtual environments proposed setup least three users walk interact freely untethered area required equipment worn body rendering performed locally user minimize latency inside optical head tracking coupled low cost motion capture suit track full body head movements users interactions positions selected real world objects distributed wireless network server client architecture result users see effect interactions objects users real time describe architecture implemented proof concept system
study investigates effects media frames attitudes toward video games perceptions users consequences prior research shown gaming controversial issue media coverage focusing either risks opportunities examine effects portrayals present study used experimental design exposed participants news article framed gaming terms risk opportunity journalistic level level corresponding expert statement examining perceived negative effects games study extends previous research combining framing third person research results showed framing gaming indeed effect participants attitudes framing effect moderated individual video game use despite identifying traditional third person perception regarding negative video game effects found framing significant influence third person perceptions
design principles technical characteristics considered computerized suite providing metrological service wide range radio electrical measuring instruments high degree independence
wide spectrum geotechnical applications materials undergo large deformations large displacements modeling problems lagrangian finite element method mesh become distorted meshing essential past decades considerable efforts made adopt called meshfree methods mitigate problems related mesh distortion one methods material point method mpm represents continuum field lagrangian material points particles move fixed background eulerian mesh paper tensile membrane modeled using coupled fem mpm approach adopts two dimensional triangular elements membrane discretisation free move three dimensional mesh non structured tetrahedral elements apart membrane soil treated classical procedure mpm show potential method presented membrane scheme failure embankment without geotextile presented paper analyses failure mechanism embankment stability using undrained conditions investigated determine critical embankment height corresponding geotextile forces sake comparison plaxis large deformation formulation considered reference solution
recording growth stage information important aspect precision agriculture crop breeding phenotyping practice crop growth stage still primarily monitored eye laborious time consuming also subjective error prone application computer vision digital images offers high throughput non invasive alternative manual observations use agriculture high throughput phenotyping increasing paper presents automated method detect wheat heading flowering stages uses application computer vision digital images bag visual word technique used identify growth stage heading flowering within digital images scale invariant feature transformation feature extraction technique used lower level feature extraction subsequently local linear constraint coding spatial pyramid matching developed mid level representation stage end support vector machine classification used train test data samples method outperformed existing algorithms yielded early medium late stages heading respectively accuracy flowering detection results also illustrate proposed method robust enough handle complex environmental changes illumination occlusion although proposed method applied identifying growth stage wheat potential application crops categorization concepts disease classification
spin logic asl devices provide promising spintronics based alternative boolean logic implementations post complementary metal oxide semiconductor cmos era principle logic functionality implemented asl practice performance asl gate significantly affected layout choices implications adequately explored past article proposes systematic approach building standard cells asl basic building block overall design methodology implementing large asl based circuits first propose new technique reduce magnet count asl majority gate still ensure correct functioning layout optimization methods building physics based analysis build standard cell library diverse functionality characterize library delay energy area perform delay optimized technology mapping iscas benchmark circuits using library approach results circuits faster consume less energy area efficient compared standard cell library incorporate layout based optimization techniques work
paper analyse state art regarding sports injuries sport psychology perspective first section introduce concept definition important variables levels causes types four models explain relationship factors vulnerability level injury presented table second section called historical evolution spain make record main research lines different authors groups field sport psychology spain finally third section papers included monographic introduced contribution first
use smartphone technology increasingly considered state art practice travel data collection researchers investigated various methods automatically predict trip characteristics based upon locational smartphone sensing data trip characteristics studied trip purpose prediction received relatively less attention research develops trip purpose prediction models based upon online location based search discovery services specifically google places api limited set trip data usually available upon completion trip models potential integrated smartphone technology produce real time trip purpose prediction use recent large scale travel behavior survey augmented downloaded google places information trip destination develop validate models two statistical machine learning prediction approaches used including nested logit random forest methods sets models show google places information useful predictor trip purpose situations activity person related information uncollectable missing unreliable even activity person related information available incorporating google places information provides incremental improvements trip purpose prediction elsevier ltd rights reserved
taking account perturbative corrections einstein maxwell gravity study thermodynamical behavior black holes context geometrical thermodynamics consider quadratic maxwell invariant correction maxwell theory electromagnetic viewpoint gauss bonnet gravity correction theory gravitational point view study thermodynamical phase transition show employing weinhold ruppeiner quevedo approaches fails produce desirable results next hendi panahiyan eslam panah momennia hpem metric employed order study solutions show metric capable matching divergence points thermodynamical curvature scalar phase transition bound points moreover effects variation different parameters phase transition points investigated
paper designs implements embedded security gateway based double homed structure composed software hardware parts core hardware platform based two processors one epcf fpga software based reduced linux kernel gateway uses net filter tables firewall ipsec vpn network isolation technologies effectively reduce risk transmitting information public network improve defensive capability applied business high security level
effective software effort estimation one challenging tasks software engineering various alternatives introduced enhance accuracy predictions respect estimation approaches based algorithmic models widely used models consider modeling software effort function size developed project however approaches sharing common thread complex mathematical models face difficulties parameters calibration tuning study proposes using directed artificial bee colony algorithm order tune values model parameters based past actual effort proposed methods verified nasa software dataset obtained results compared existing models literature results indicated proposal significantly improved performance estimations
mast cells effector cells immunoglobulin ige mediated immediate hypersensitivity allergic diseases asthma food allergy mast cells activated aggregation ige bound high affinity ige receptor fceri multivalent antigen activated mast cells secrete proinflammatory mediators histamine serotonin proteases produce cytokines chemokines however reported mast cells activated crosslinking fceri monomeric ige absence antigen recently demonstrated histamine releasing factor hrf involved ige mediated mast cell activation vitro vivo hrf binds subset ige igg molecules hrf reactive antibodies abs fab portions ige igg molecules hrf binding sites terminal residue portions hrf hrf reactive binding sites observed tagged glutathione transferase gst gst gst inhibit interaction hrf hrf reactive abs using acute late phase passive cutaneous anaphylaxis mouse models shown hrf initiates mast cell activation hrf reactive hrf nonreactive ige vivo antigen induced passive cutaneous anaphylaxis inhibited pretreatment gst gst demonstrated pretreatment gst antigen challenge inhibited antigen induced mast cell dependent airway inflammation addition gst partially inhibited aspergillus fumigatus extract induced ige dependent airway inflammation however gst inhibit cell dependent airway inflammation results suggest mast cells target cells hrf initiate ige mast cell dependent airway inflammation
article analyzes association civil conflicts educational achievement studying turkish case combines university entrance exam scores million students newly constructed data set casualties turkish kurdish conflict study association conflict educational achievement turkish students results reveal significant negative association combined already well established positive links education various measures socioeconomic development like economic growth social equality public health results article demonstrate education one channels civil conflicts damage well societies thereby creating conditions perpetuate
paper presents initial findings ongoing research effort focused identifying quantifying ranking essential industry practices successful delivery faster fast track flash track projects research data collection involves literature search engineering procurement construction industry interviews discussions industry expert panel research extensively explored analyzed international practices deeply explored project execution practices industries construction including manufacturing shipbuilding software engineering development methodology employed research entails deployment three round delphi process analytic hierarchy process produce comprehensive list prioritized recommendations essential flash track practices paper contributes body knowledge identifying ranking industry best practices essential successfully manage unique challenges risks inherent flash track projects research finds planning execution organizational practices essential considerations successful flash tracking also highlights central role trusting relationships fully integrated work teams extends earlier studies calling innovative approaches rethinking prevailing practices entertaining new paradigm flash track projects american society civil engineers
objectives olfactory bulb plays pivotal role processing olfactory information aim study investigate volume changes possible associations nasal septal deviation study design cross sectional study setting otolaryngology department bozok university school medicine neurology department yozgat state hospital subjects methods ninety patient cranial magnetic resonance imaging mri studies males females mean age years range years isolated nasal septal deviations recruited study olfactory bulb volumes study subjects evaluated weighted coronal mri images planimetric manual contouring results nasal septal deviation angles found range degrees degrees mean degrees degrees right sided deviations included mild degrees group moderate degrees degrees group severe degrees group iii patients left sided deviations included mild degrees group moderate degrees degrees group severe degrees group iii subjects olfactory bulb volumes calculated right left sided deviation groups patients left sided septal deviations groups iii left volumes groups iii right volumes respectively statistical evaluation right volumes produce significant difference groups authors demonstrated statistically significant differences comparison groups iii groups iii respectively right septal deviation group groups iii mean volumes right volumes respectively left volumes respectively statistically significant difference groups left volumes right sided deviation group statistically significant difference demonstrated groups iii groups iii compartments conclusion study mild moderate septal deviations lacked significant affect volumes severe deviations found significant impact parameter additionally contralateral volumes severe septum deviation group significantly bigger compared ipsilateral volumes multidisciplinary studies required evaluate clinical significance volume changes diagnosis follow several otolaryngologic nonotolaryngologic diseases
aggregate makes high mass fraction asphalt pavements morphological characteristics aggregate shape factors angularity surface texture significantly affect mechanical performance asphalt pavement extensive investigations aggregate morphology conducted coarse aggregate recent years however analysis fine aggregate carried date commonly used methods extrapolate information morphology fine aggregate sand flow test sft uncompacted void content test uvct give general characterization aggregate morphology without allowing differentiated conclusions regarding respective morphological factors study digital image processing dip used determine morphological index values fine aggregate data dip compared results uvct sft means correlation analyses investigate applicability precision respective methods uvct sft found strongly reliable absolute grain size rendering methods less resilient dip well suited determine specific morphological indices fine aggregates useful tool design asphalt mixtures elsevier ltd rights reserved
pic mcc simulation model analysis low temperature discharge plasmas represented takes common leapfrog velocity verlet algorithm particle integration adaptive particle management well parallel computing using mpi account main features model including impact super particle numbers adaptive particle management time step size different integration methods represented investigations performed low pressure capacitively coupled radio frequency discharges helium argon besides code verification comparison benchmark simulation results helium shown adaptive particle management particularly suitable simulation discharges elevated pressures boundary effects processes sheath regions important furthermore pointed velocity verlet integration scheme allows speed pic mcc simulations compared leapfrog method makes use larger time steps accuracy possible elsevier rights reserved
libraries collection implementations behavior written computer programming language providing well defined interface behavior invoked although majority code numerous applications comes libraries risk security vulnerabilities comes libraries often overlooked regard seek assess threat landscape associated software libraries discuss mitigation strategies via security development lifecycle sdl
juvenile idiopathic arthritis common chronic rheumatic disease unknown aetiology childhood predominantly presents peripheral arthritis disease divided several subgroups according demographic characteristics clinical features treatment modalities disease prognosis systemic juvenile idiopathic arthritis one frequent disease subtypes characterized recurrent fever rash oligoarticular juvenile idiopathic arthritis common among young female patients usually accompanied anti nuclear antibodie positivity anterior uveitis seropositive polyarticular juvenile idiopathic arthritis analogue adult rheumatoid arthritis seen less paediatric patients seronegative polyarticular juvenile idiopathic arthritis entity specific childhood appears widespread large small joint involvement enthesitis related arthritis separate disease subtype characterized enthesitis asymmetric lower extremity arthritis disease subtype represents childhood form adult spondyloarthropathies human leukocyte antigen positivity uveitis commonly without axial skeleton involvement juvenile psoriatic arthritis characterized psoriatic rash accompanied arthritis nail pitting dactylitis disease complications vary growth retardation osteoporosis secondary treatment disease activity life threatening macrophage activation syndrome multi organ insufficiency advent new therapeutics past years marked improvement juvenile idiopathic arthritis treatment long term outcome without sequelae treatment juvenile idiopathic arthritis patients involves teamwork including experienced paediatric rheumatologist ophthalmologist orthopaedist paediatric psychiatrist physiotherapist primary goals treatment eliminate active disease normalize joint function preserve normal growth prevent long term joint damage timely aggressive treatment important provide early disease control first line treatment includes disease modifying anti rheumatic drugs methotrexate sulphasalazine leflunomide combination corticosteroids used different dosages routes oral intravenous intraarticular intra articular application steroids seems effective treatment modality especially monoarthritis biological agents added treatment unresponsive patients anti tumour necrosis factor agents etanercept infliximab adalimumab anti interleukin agents anakinra canakinumab antiinterleukin agents tocilizumab cell regulatory agents abatacept shown safe effective childhood patients recent studies reported sustained reduction joint damage even complete clinical improvement paediatric patients compared previous data
ganoderma lucidum species basidiomycetes class attracting international attention owing wide variety biological activities great potential ingredient skin care cosmetics including skin whitening products however little information available inhibitory effect tyrosinase activity therefore objectives study investigate chemical composition lucidum inhibitory effects melanogenesis isolated active compound lucidum using ethanol extraction ethyl acetate fractionation addition assayed inhibitory effects tyrosinase activity melanin biosynthesis melanoma cells study identified bioactive compound ganodermanondiol inhibits activity expression cellular tyrosinase expression tyrosinase related protein trp trp microphthalmia associated transcription factor mitf thereby decreasing melanin production furthermore ganodermanondiol also affected mitogen activated protein kinase mapk cascade cyclic adenosine monophosphate camp dependent signaling pathway involved melanogenesis melanoma cells finding ganodermanondiol lucidum exerts inhibitory effect tyrosinase contribute use mushroom preparation skin care products future
study reports first time full charging state art mobile smartphone using microbial fuel cells fed urine possible employing new design mfc allowed scaling without power density losses although demonstrated past basic mobile phone could charged mfcs present study goes beyond show simply using urine mfc system successfully charges modern day smartphone several energy harvesting systems tested results demonstrated charging circuitry commercially available phones may consume energy top battery capacity study concludes developing mobile phone charger based urine results phone operation outgoing call every charge time little per charge real neat urine authors published elsevier ltd open access article license
concept energy widely employed introductory science courses however term energy defined utilized different ways depending context even within given discipline lens metaphor theory various definitions energy seen metaphors highlight obscure characteristics energy working framework undergraduate students introductory biology chemistry physics courses asked write analogies reflect understanding role energy context ecosystems chemical reactions mechanical systems electrical circuits analogies analyzed qualitatively using metaphor theory gain understanding students conceptualize energy different contexts results study indicate students use seven different conceptual metaphors explain role energy various scientific contexts energy substance accounted energy substance flow change forms carried lost ingredient product energy process interaction result gives teachers framework use evaluating student ideas energy
purposethis study tested effectiveness pressure ulcer prevention bundle reducing incidence pus critically ill patients two saudi intensive care units icus designa two arm cluster randomized experimental control trial methodsparticipants intervention group received prevention bundle control group received standard skin care per local icu policies data collected included demographic variables age diagnosis comorbidities admission trajectory length stay clinical variables braden scale score severity organ function score mechanical ventilation presence staging patients followed every two days admission discharge death maximum days data analyzed descriptive correlation statistics kaplan meier survival analysis poisson regression findingsthe total number participants recruited control participants total days observation intervention participants days observation cumulative incidence significantly lower intervention group compared control group poisson regression revealed likelihood development lower intervention group intervention group significantly less stage stage development conclusionssignificant improvements observed related outcomes implementation prevention bundle icu incidence severity total number pus per patient reduced clinical relevanceutilizing bundle approach standardized nursing language skin assessment translation knowledge practice potential impact positively quality care patient outcome
study sought chart morphological changes taking place goat abomasum prenatal development using histomorphometric immunohistochemical techniques total goat embryos fetuses first stages prenatal life birth differentiation abomasum separate compartment primitive gastric tube observed days prenatal life crl gestation primitive abomasal folds first observed days crl gestation muscularis mucosae visible days crl gestation transformation pseudostratified epithelium simple cylindrical epithelium also observed stage differentiation gastric pits glands first became apparent days crl gestation days crl gestation respectively neuroendocrine cells detected synaptophysin syp days crl gestation glial cell markers glial fibrillary acidic protein gfap vimentin vim observed days crl gestation days crl gestation respectively neuropeptide npy vasoactive intestinal polypeptide vip detected days crl gestation gastrin immunoreactive cells first appeared abomasum days crl gestation conclusion prenatal development abomasum appears take place somewhat earlier goats sheep cattle similar rate reported wild ruminants deer
paper presents perception sensor network psn detect audio based emergency situations human scream psn consists multiple units kinect pan tilt zoom camera audio signals acquired kinect microphone array used sound source classification sound source localization order work multi person scenarios propose audio visual fusion method detect single speaking person among multiple ones psn system demonstrated scenario four persons system able detect localize screaming person send robot location check condition
describing dispersion decreasing fiber variable coefficient nonlinear schrodinger equation hereby investigation three transformations obtained equation known standard cylindrical nonlinear schrodinger equations relevant constraints variable coefficients presented turn general previously published literature meanwhile several families exact dark soliton like bright soliton like solutions constructed also obtain similarity solutions illustrated terms elliptic second painleve transcendent equations
energy conservation crucial wireless sensor networks wsns prolonging sensor node life research attempts gain benefits bayesian classifier development bayesian classifier based energy aware routing algorithm bbear mobile wsns implementing bayesian classifier routing process superior routing algorithm designed intelligent node message rebroadcast decision paper discusses proposed algorithm design presents comparison performance flooding technique bbear workflow described along classifier mechanism allows message routing judgment sensor node based several node message classifying attributes contrast routing schemes developed wsn bbear algorithm incorporates several node attributes including remaining energy nodes distance sink number messages queued node success rate delay received message well number message duplicates received node bbear performance also discussed evaluated terms various measures throughput number duplicates received average delay lifetime nodes simulation study proposed algorithm shows superiority flooding provides gain message throughput four times reduction duplicates gives extension nodes lifetime still maintaining delay delay jitter low levels
several options emergency contraception available united states article describes method including efficacy mode action safety side effect profile availability effective emergency contraceptive copper intrauterine device iud followed ulipristal acetate levonorgestrel pills levonorgestrel available sale without restrictions whereas ulipristal acetate available prescription copper iud must inserted clinician although pills shown reduce pregnancy abortion rates population level important option individual women seeking prevent pregnancy sex
background acotiamide widely used improve symptoms patients functional dyspepsia multiple large scale clinical studies reports drug mechanism action aim study assess effects acotiamide gastric accommodation gastric emptying gastrointestinal symptoms health related quality life qol placebo controlled study methods conducted randomized double blind placebo controlled study fifty japanese patients randomly assigned either placebo acotiamide day weeks baseline weeks treatment evaluated patients gastric motility using scintigraphy determine accommodation emptying values gastrointestinal symptom rating scale gsrs qol anxiety depression scale hads results four patients failed complete medication regimen omitted analysis data placebo patients acotiamide patients analyzed acotiamide significantly increased gastric accommodation compared placebo respectively acotiamide significantly accelerated gastric emptying half emptying time acotiamide significantly improved total gsrs scores compared placebo qol differ significantly two groups acotiamide significantly improved hads anxiety score compared placebo conclusions placebo controlled study demonstrated acotiamide significantly increased gastric accommodation gastric emptying japanese patients acotiamide also improved patients dyspeptic symptoms anxiety score
subclinical hypothyroidism defined elevated serum thyrotropin presence normal free thyroid hormones lipid metabolism influenced thyroid hormone many reports showed lipids status worsen alongwith tsh level subclinical hypothyroidismhas also linked cardiovascular risk factors alteration blood pressure increased atherosclerosis evidences suggested mild dysfunction thyroid gland associated withmetabolic syndrome heart failure thyrotropin level seems best predictor cardiovascular disease particular levels however despite observations clear evidence levothyroxine therapy subjects milder form subclinical hypothyroidism could improve lipid status cardiovascular risk factors review address effect thyroid hormone cardiovascular risk focus lipid metabolism european federation internal medicine published elsevier rights reserved
recent studies integrating vibration control structural health monitoring shm use control devices control algorithms enable system identification damage detection study real time shm used enhance structural vibration control reduce damage newly proposed control algorithm including integrated real time shm semi active control strategy presented mitigate damage seismic response main structure strong seismic ground motion semi active independently variable stiffness saivs device used semi active control device investigation proper stiffness saws device obtained using new developed semi active control algorithm based real time damage tracking structure damage detection algorithm based identified system markov parameters dda ismp method three bay five story steel braced frame structure equipped one saws device story employed illustrate efficiency proposed algorithm obtained results show proposed control algorithm could significantly decrease damage parts structure also dynamic response structure effectively reduced using proposed control algorithm four strong earthquakes comparison passive cases results demonstrate performance proposed control algorithm decreasing damage dynamic responses structure significantly enhanced passive cases furthermore energy consumption point view maximum cumulative control force proposed control algorithm less passive case considerably
installation wireless sensor networks power substations becoming unavoidable developing smart electrical network high voltage equipment power substation may produce impulsive noise happens much troublesome wireless communications conventional white noise indeed choice physical layer communication network easy fits evaluate attentively advantages downsides bound different technologies communication deploying network electromagnetic environment characterized tests performed order estimate communication performances paper presents investigation zigbee ieee ghz narrowband system performance high voltage substations use recorded data measurement campaign identify models substation noise obtained modeled middleton class process recent model using several statistical tests evaluated two models first results show middleton class accurate modeling partial discharges electricity substations model accurate model impulsive noise high voltage substation compare middleton class gaussian models addition ber performances zigbee ghz phy layer studied substation environment results show impulsive noise influence close gaussian noise rayleigh noise according snr
background filaggrin encoded filaggrin gene flg important component skin barrier external environment genetic defects flg strongly associate atopic dermatitis however patients flg mutations objective hypothesized patients might possess defects filaggrin expression processing contributing barrier disruption therefore present novel therapeutic targets disease results describe relationship mechanistic target rapamycin complex protein subunit regulatory associated protein mtor complex raptor serine threonine kinase akt murine thymoma viral oncogene homolog akt protease cathepsin ctsh establish role filaggrin expression processing increased raptor levels correlated decreased filaggrin expression patients keratinocyte cell cultures raptor upregulation akt short hairpin rna knockdown reduced expression protease ctsh skin ctsh deficient mice ctsh short hairpin rna knockdown keratinocytes showed reduced filaggrin processing mouse impaired skin barrier function mild proinflammatory phenotype conclusion findings highlight novel potentially treatable signaling axis controlling filaggrin expression processing defective patients
region based hierarchical image representation crucial many computer vision applications however practice image hierarchy usually dense contains many less informative branches expected hierarchy accurate simplified desirable different applications also saves considerable computational load analysis achieve target paper proposes novel approach unsupervised simplification region based image hierarchies employs global local evolution analyses hierarchy first introduce global evolution analysis scale sets framework provides clues eliminating less informative branches moreover hybrid unsupervised simplification method designed utilizing information global local evolution functions number experiments various images shown proposed approach effective efficient removing less informative nodes averagely whole nodes preserving salient image details retaining accuracy
prominent issues field family psychology term editor journal briefly noted including focus marital issues divorce remarriage family conflict parenting attachment parent child relationships also significant topics period special sections journal focused cultural variations families law families religion family routines rituals several neglected issues need attention future noted include need recognize embeddedness families socioecological contexts importance monitoring impact secular changes families value limitations viewing family psychology separate field topics future agenda include challenge defining family midst changing family forms effects technological change families challenges integrating biological research family psychology agenda multilevel bio social approach family research recommended
hydrogen extracted naturally stored long time different types fuel cells developed generate clean power particularly use vehicles however power demand running vehicle leads unstable irregular loading fuel cells reduces fuel cell lifespan efficiency also affects driving safety slow output response satisfy abrupt increase power demand magnetic flywheels characteristics high energy density high speed charging ability low loss extensively used formula one cars study developed hybrid powertrain magnetic flywheel system mfs integrated fuel cells solve aforementioned problems moreover auto tuning proportional integral derivative pid controller based controls multiple adaptive neuro fuzzy interference system particle swarm optimization designed mfs control furthermore matlab simulink simulations considering ftp urban driving cycle conducted variability improvement approximately fuel cell output achieved elsevier ltd rights reserved
poly adp ribose polymerase parp enzyme contributes nephropathy serious diabetic complication may lead end stage renal disease study aims investigate effect parp activation kidney functions type diabetic rat model study also tests therapeutic use parp inhibitors diabetic nephropathy type diabetes induced adult male rats high fructose high fat diet low streptozotocin dose parp inhibitor aminobenzamide administered daily weeks end urine samples collected measure urine creatinine albumin total proteins parp activity superoxide dismutase sod activity nitrite content measured kidney tissue homogenate glucose fructosamine insulin tumor necrosis factor alpha tnf alpha measured serum furthermore histological studies collagen deposition immunofluorescence nuclear factor kappa kappa transforming growth factor beta tgf beta carried parp enzyme activity significantly higher diabetic group significantly reduced administration diabetic animals clear nephropathy indicated proteinuria increased albumin excretion rate aer significantly decreased parp inhibition addition parp inhibition increased creatinine clearance diabetic animals reduced renal tgf beta glomerular fibrosis moreover parp inhibition alleviated elevated serum tnf alpha level renal kappa nitrite decrease sod activity diabetic animals however parp inhibition significantly affect neither hyperglycemia insulin sensitivity parp enzyme inhibition alleviates diabetic nephropathy decreasing inflammation oxidative stress renal fibrosis
parametric surfaces essential modeling tool computer aided design movie production even though use well established industry generating ray traced images adds significant cost time memory consumption ray tracing surfaces usually accomplished subdividing surfaces fly conversion polygonal representation however fly subdivision computationally expensive whereas polygonal meshes require large amounts memory particular problem parametric surfaces displacement fine tessellation required faithfully represent shape hence memory restrictions major challenge production rendering article present novel solution problem propose compression scheme priori bounding volume hierarchies bvhs parametric patches reduces data required hierarchy factor propose approximate evaluation method require leaf geometry yielding overall reduction ofmemory consumption factor regular bvhs indexed face sets factor established state art compression schemes alternatively compression simply applied standard bvh keeping leaf geometry resulting compression rate current methods although decompression generates additional costs traversal manage complex scenes even memory restrictive gpu competitive render times
study intelligent energy efficient outdoor lighting control system developed could used green buildings well intelligent building functions contribute reduction carbon dioxide emissions using conservation electric energy daylight efficiently intelligent energy efficient lighting control system based expert system one artificial intelligence techniques four functions running real time first function controlling monitoring lamp groups functions fault diagnosis lambs power lines connected lamp groups load estimation lamp groups expert system written two separate computer microcontroller based environments using knowledge based rules rule base real time control monitoring function contains rules education semester operation mode real time control monitoring function implemented average conservation achieved energy consumption system first expert system application expert system used control monitor outdoor lighting well perform load estimate fault diagnosis elsevier rights reserved
extracting critical sections project management documents challenging process active area research project management documents contain certain earlywarnings modelled properly may inform project planners managers advance impending risks via early warnings extraction indicators documents termed text mining active area research context construction project management extraction semantically crucial information documents challenging task turn used provide decision support optimising entire project lifecycle research presents two step modelling clustering methodology exploits capability nalve bayes classifier extract early warnings management text data first step database corpus prepared via qualitative analysis expertly fed questionnaire responses latter stage naive bayes classifier proposed evaluates real world construction management documents identify potential risks based certain keyword usages classifier outcome compared labelled test documents gave accuracy better majority text mining algorithms reported literature
amp activated protein kinase ampk complicated heterotrimer sense cellular energy status maintain energy homeostasis via switching catabolic anabolic pathways ampk also participates regulation many life activities including cell cycle cell polarity autophagy life span therefore ampk widely studied potential drug target treatment type diabetes metabolic diseases cancers cardiovascular diseases similar kinases phosphorylation thr activation loop upstream kinases crucial activation ampk addition binding amp analogues subunit causes allosteric activation makes ampk distinctive kinases give brief introduction domain constitutions mammalian ampk systematically review allosteric activation mechanism structural biochemical view
business life generally percieved male activity energy exhaustive nature consequently organisations expecting work quality taht reflects male standards living terms availability assertiveness led organizations shape leadership model masculine principles values present study examines whether female leadership seen effectice male leadership middle eastern context survey distributed random sample employees wiorking public sector based united arab emirates group informal interviews held investigate quantitaive findings results obtained participants revealed average population see male leaders gain control employees female leaders see male leaders better female leaders making decisions versus see opposite side see female leaders insirational male leaders viewed female leaders better observational abilities male leaders middle east work environment cronbach alpha paper conludes highlight role educaiton building social construction gender forms individuals perception gender roles result stereotypes emerge affecting view leaders regardless ther actual current abilities iase publisher rights reserved
initial teacher education imply preparing student teachers knowing thinking understanding involves supporting student teachers developing understanding order act several specialists recommended case pedagogy initial teacher education arguing help teacher educators overcome shortcomings traditional models teacher education greatly enhance teacher professional development case pedagogy based idea new knowledge constructed connection prior knowledge directly related experience transformable change overtime addition case pedagogy helps student teachers understand complexity teaching encourages experimentation innovation teaching paper maintain case pedagogy encourages critical reflection facilitates understanding theory helps teachers develop problem solving skills linking teaching research professional development
purpose reasons social gradient cancer survival fully understood yet previous studies often able determine socio economic status patients area live individual socio economic characteristics methods multi centre cohort study cancer patients year follow individual socio economic position measured using indicators education job grade job type equivalence income effect survival measured indicator individually adjusting age gender medical characteristics mediating effect health behaviour alcohol tobacco consumption analysed separate models results patients without vocational training increased risk dying rate ratio confidence interval compared patients highest vocational training patients blue collar jobs increased risk compared patients white collar jobs income gradual effect lowest income compared highest adding health behaviour models change effect estimates considerably evidence effect school education job grade cancer survival conclusions patients higher income better vocational training white collar jobs survived longer regardless disease stage baseline tobacco alcohol consumption
past research documents extent discrimination experiences observations undermine people health performance addition discrimination direct consequence targets discrimination implicates morality larger community occurs perceptions community morality could predict community identification turn could predict health performance test serial mediation hypothesis second third year university undergraduates reported frequency discrimination observations experiences students perceptions university community morality mediated relationship discrimination extent identified university turn university identification mediated relationship university morality students academic engagement mental health however university morality reliably mediated relationship discrimination physical health discrimination affect health engagement community members even observers part targeted group
mendae plain abraha atsbaha tigray region northern ethiopia agricultural area drought prone past last decade agricultural development boosted intensive use large diameter wells tap phreatic aquifer pumped water used irrigation long dry season october may since years water harvesting measures implemented mainly form infiltration ponds trenches enhance local infiltration rainfall runoff hillslopes investigate sustainability groundwater exploitation efficiency measures different recharge discharge components water balance data scarce mendae plain identified quantified using different methods diffuse aquifer recharge calculated soil moisture balance based meteorological data chloride mass balance method based groundwater analyses diffuse recharge much higher cultivated land plots non cultivated bare soils rainfall infiltration ponds trenches estimated based inflow catchment derived topography groundwater flow nearby river obtained balancing inflow outflow components year period balance components integrated lumped parameter model run period results show infiltration ponds trenches contributes nearly total aquifer recharge highest values dry years changes aquifer storage time indicator evolution groundwater levels aquifer confirm occurrence two dry periods copyright john wiley sons ltd
paper proposes systematic method allocate power flow loss deregulated transmission systems proposed method developed based basic circuit theories equivalent current injection equivalent impedance four steps used trace voltages currents power flows losses contributed generator sequentially using method real reactive power transmission lines sources destinations calculated loss allocation line produced generator also obtained test results show proposed method satisfy power flow equation power balance equation basic circuit theories comparisons previous methods also provided demonstrate contributions proposed method elsevier ltd fights reserved
background track field one popular high school sports among boys girls epidemiological research sport individual events limited purpose describe injury rates patterns boys girls high school track field study design descriptive epidemiology study methods retrospective epidemiological analysis injury exposure data longitudinal national high school sports injury surveillance system conducted results track field injuries occurred athlete exposures injuries per athlete exposures injury rates higher competition versus practice sexes girls higher injury rates boys overall rate ratio practice rate ratio competition injury rates differ overuse chronic injuries accounted boys girls track field injuries respectively majority injuries lower extremity sprints distance running jumps accounted track injuries boys sustained greater proportion injuries relay events injury proportion ratio fewer hurdle events injury proportion ratio conclusion injury rates varied event sex competition versus practice exposure increase effectiveness targeted strategies injury prevention driven understanding differences many track field injuries overuse chronic across sexes competitions practices coaches athletic trainers adept recognizing early injury symptoms intervene treat minor injuries order prevent severe injuries ensure prompt diagnosis management injuries
relation reentrant activity occurrence cardiac arrhythmias still topic intensive investigation reentries strictly related enhanced complex structure cardiac tissue characterized multi sized electrophysiological spatial heterogeneities however structure function tissue sometimes also promote phenomena spontaneous termination waves role played tissue scenario well understood yet investigation study implemented bidomain formulation phase luo rudy action potential model ischemic conditions investigate size ischemic heterogeneities tissue conduction properties may affect system dynamics drive towards maintenance reentrant activity quiescence main findings show stability waves changes conductivity intracellular space critical alterations extracellular space maintenance self termination pinned spirals strongly dependent size heterogeneities also degree intracellular anisotropy findings confirm extend results obtained previous investigations addition since experimental values conductivity tensors reported literature consistent overview possible scenarios arising broader range assumed anisotropy values provided relation different sizes ischemic heterogeneities perspective simulations shown compare impact different degrees tissue anisotropy wave dynamics authors published elsevier
although theories narcissism describe experience emptiness possible mechanism addictive behaviors compulsive buying link examined empirically study investigated relationships narcissistic grandiosity vulnerability emptiness materialism compulsive buying among adults participants included israeli adults males mage completed battery self reported questionnaires results show narcissistic grandiosity narcissistic vulnerability materialism emptiness negatively related compulsive buying furthermore emptiness mediated relationships narcissistic vulnerability compulsive buying materialism mediated relationships narcissistic grandiosity compulsive buying findings highlight differential associations two facets pathological narcissism compulsive buying lend empirical support importance emptiness experience compensatory behaviors compulsive buying vulnerable narcissist
sustainability become major concern construction industry growing emphasis green buildings last decade renovation critical terms improving energy efficiency building stock paper green building certification process existing buildings developing countries investigated qualitative case study methodology employed gain better understanding critical success factors greening certification process respect six leadership energy environmental design leed certified projects turkey examined framework used analyze components process including drivers resources green implementations barriers enablers benefits impacts unavailability approved materials poor design buildings difficulties documentation process major barriers barriers overcome commitment owners top management support collaborative working among project parties findings study expected guide construction professionals certifying existing buildings effective manner similar studies may conducted existing buildings different countries different regulations conditions exist proposed framework also employed investigate certification process new construction projects american society civil engineers
study system two parabolic nonlinear reaction diffusion equations subject nonlocal boundary condition system nonlinear equations used mathematical modeling biosensors bioreactors integral type nonlocal boundary condition links solution system boundary integral solution within system inner range integral plays important role nonlocal boundary condition general formulation boundary value problem solution boundary points calculated using integral combined proportional integral derivative controller algorithm mathematical model applied modeling control drug delivery systems prodrug converted active form enzyme containing bioreactor delivering body linear exponential stepwise protocols drug delivery investigated corresponding mathematical models prodrug delivery created
use cyanobacteria removal heavy metals wastewater gaining interest due lower cost operation environmentally benign chromium potentially toxic carcinogenic humans removal water wastewater obligatory order avoid water pollution present study capacity living cyanobacterial consortium consisting limnococcus limneticus leptolyngbya subtilis collected east kolkata wetland wetland international importance removal investigated different operating conditions input variables initial concentration inoculum size varied using one factor time ofat analysis range respectively optimum removal achieved days inoculation initial concentration inoculum size scanning electron microscopy sem energy dispersive spectroscopy eds studies ascertained uptake living consortium fourier transform infrared spectroscopy ftir study revealed amine phosphate carbonyl groups involved binding vis vis biosorption increase inoculum size improves percentage removal assess possibility biofuel production cells harvested dry biomass lipid content increase dry biomass lipid content observed living consortium grown contaminated simulated wastewater instead medium regression model developed predict interactive effect four input variables namely initial concentration initial solution inoculum size time three output variables namely dry biomass lipid content percentage removal finally response surface methodology rsm employed optimize process conditions removal optimum condition obtained rsm study initial concentration inoculum size time days predicted percentage removal matches quite well experimental one elsevier ltd rights reserved
switched capacitors commonly used analog circuits increase accuracy analog signal processing lower power consumption take full advantage switched capacitors important achieve accurate capacitance ratios layout capacitor arrays affected systematic random mismatches good capacitor placement common centroid structure highest possible degree dispersion mitigate mismatches several dummy units inserted make placement shape square compact paper proposes simulated annealing based approach mismatch aware common centroid placement constraints pair sequence representation used record placement couple associated operations developed find better solutions experimental results show proposed placements achieve smaller oxide gradient induced mismatch larger overall correlation coefficients higher degree dispersion previous works
purpose aim study investigate homophobic attitudes three european countries italy albania ukraine one thousand forty eight students recruited italian albanian ukrainian university centers methods socio demographic questionnaire homophobia scale administered staff results cross cultural significant differences among italian albanian ukrainian students found homophobia scale italy mean albania mean ukraine mean analysis sociodemographic characteristics revealed male gender emerged main predictor homophobic attitude three countries although also conservative political orientation religious belief predict higher homophobia levels italy albania particularly conclusions study revealed european countries assessed attitudes toward homosexuality different ukrainians display higher levels homophobia albanians italians confirming central role cultural differences homophobic attitudes nevertheless socio demographic aspects identification male similar influence homophobic attitudes assessed populations
background chronic conditions increasing challenge individuals health care system smartphones health apps potentially promising tools change health related behaviors manage chronic conditions objective aim study explore extent smartphone health app use sociodemographic medical behavioral correlates smartphone health app use associations use apps app characteristics actual health behaviors methods population based survey among germans aged years older conducted sociodemographics presence chronic conditions health behaviors quality life health literacy well use internet smartphone health apps assessed questionnaire home visit binary logistic regression models applied results found participants used smartphone compared nonusers smartphone users younger research internet likely work full time likely university degree engaged physical activity less low fat diet higher health related quality life health literacy among smartphone users used health apps app users younger less likely native german speakers research internet likely report chronic conditions engaged physical activity low fat diet health literate compared nonusers smartphone health apps focused smoking cessation healthy diet weight loss common app characteristics planning reminding prompting motivation provision information significant associations found planning health behavior physical activity feedback monitoring physical activity feedback monitoring adherence doctor advice conclusions although many smartphone health app users substantial proportion population engaged findings suggest age related socioeconomic related literacy related health related disparities use mobile technologies health app use may reflect user motivation change maintain health behaviors app developers researchers take account needs older people people low health literacy chronic conditions
past decades coal bed methane cbm become important source energy especially north america methane adsorbed within coal near liquid state open fractures cleats commonly saturated water develop cbm reservoir water fracture coal seam must continuously pumped coal seam reduce pressure desorb gas matrix although operators desire produce hydrocarbon quickly fast dewatering rate irreversibly damage matrix desorption process lead unfavorable ultimate recovery aggressive production rate potentially release coal fines drive pump increases maintenance effort cost even worse watering process fluctuates rock porosity permeability changes resulting brittle coal seam pressure reduction therefore critical adjust pump operating parameters timely manner maintain continuous intermittent production ten cbm wells located remote area makes access wellsites difficult previously engineers evaluate well performance optimize pump site limited monthly basis firstly developed automatic data processing system using advanced echosounders measure water level real time reservoir pressure monitored dynamically interpreting detected water level automatic wireless data transferring system installed site closed loop control program receive process interpret data pump operating parameters changed real time remote control system identifies downhole problems real time also reduces pump maintenance frequency days days statistically numbers trip well site gas production rate averagely improved wells authors firstly developed automation data processing control system favor advanced echosounders based interpreted reservoir pressure avoid aggressive production adjusting pump operating parameters real time eventually results better ultimate recovery developed workflow automatic echosounder data acquisition real filed data transferred central office data processing interpretation simulation computational system adjustment commands operating system especially valuable locations difficult access elsevier rights reserved
human hair valuable contributor biological monitoring information storage point assess effects environmental nutritional occupational sources body human proteins amino acids compounds among key components find sources different effects disorders human body sulfur significant one compounds great affinity metals compounds property sulfur affects human health positively negatively manuscript sulfur determined hair samples autistic age match control group children via molecular absorption using high resolution continuum source graphite furnace atomic absorption spectrometer purpose hair samples appropriately washed dried degrees samples dissolved microwave digestion using hno sulfur determination extraction performed hci hydrolysation incubation hat degrees total protein albumin determination validity method sulfur determination tested using hair standard reference materials results uncertainty limits certified values confidence level finally correlation sulfur levels autistic children hair total protein albumin levels done elsevier rights reserved
purpose study ascertain whether uses music partially mediate link personality music preference undergraduate students completed following scales brief big five inventory uses music inventory short test music preference life orientation test revised beck depression inventory perceived stress scale openness experience positively predicted preferences reflective complex jazz blues intense rebellious rock metal music inversely related upbeat conventional country pop music whereas extraversion positively related preferences energetic rhythmic rap soul genres link trait optimism music preference fully mediated prominent extraversion trait relationship openness experience music preference partially mediated cognitive uses music marginally significant analysis indicating partial mediation emotional uses music openness experience music preference trait neuroticism perceived stress depression scores correlated positively emotional uses music current findings support studying personality contextually alongside uses music investigating music preference shed light negative affect may inform emotional uses music
pillars computer science engineering cse curriculum data structures database management systems languages operating systems algorithms article explains relationship connectivity core courses authors follow pedagogy technique teach data structures considering evolution article focus method providing connectivity building blocks like data containers container iterators algorithms functors data structure explained considering property iterations problems applications three fold method followed teach includes think build discuss phases pedagogy techniques practiced authors revealed many mysteries discussed text books
background mobile technology enables high frequency mood monitoring automated passive collection data actigraphy patients efficiently less intrusively previously possible techniques increasingly deployed research clinical settings however little known approaches experienced patients explored experiences individuals bipolar disorder engaging study involving mood activity monitoring range portable wearable technologies method patients recruited wider sample individuals bipolar disorder taking part automated monitoring symptom severity amoss study oxford sub set patients participated qualitative interview followed semi structured approach results monitoring associated benefits including increased illness insight behavioural change concerns raised potential preoccupation paranoia monitoring patients emphasized need personalization flexibility importance context monitoring mood conclusions mobile electronic health approaches potential lend new insights mental health transform healthcare capitalizing perceived utility approaches patients perspective addressing concerns essential promise new technologies realised elsevier masson sas rights reserved
paper present new method modeling characterization oscillator circuit van der pol vdp model using parameter identification also discussed investigated problem estimation nonlinear system based time domain data approach based appropriate state space representation van der pol oscillator allows optimal parameter estimation using sampled output voltage signal model parameters obtained iterative identification algorithm based output error method normalization issues fixed appropriate transformation allowing quickly global minimum search finally proposed estimation method tested validated using simulation data ghz oscillator circuit gaas technology
high power applications proper gate control strategy insulated gate bipolar transistors igbts increase efficient reliability feed back control strategy key issues control speed control stability paper proposed new feed back control method integrated digital gate driver high power igbt aims controlling current voltage slope suppressing voltage overshoot electromagnetic interference emi switching transient digital gate driver large power igbt detects collector current voltage real time detected analog signal digitally sampled sent digital core board algorithm similar bang bang control deployed forward control loop adjust gate drive resistance control stability robustness guaranteed result whole detection control process accomplished real time hundreds nanoseconds thus proposed control method optimized igbt switching transient high reliability time effectiveness experimental results validate feasibility proposed feed back digital control method
order meet requirement high sensitivity signal noise ratios snr study develops optimizes piezoresistive pressure sensor using double silicon nanowire sinw piezoresistive sensing element first ansys finite element method voltage noise models adopted optimize sensor size sensor output sensitivity voltage noise snr result sensor released double sinw times sensitivity single sinw sensor consistent experimental result result also displays sensitivity snr closely related geometry parameters sinw doping concentration achieve high performance type implantation geometry long sinw piezoresistor cross area thick diaphragm required proposed sinw pressure sensor fabricated using standard complementary metal oxide semiconductor cmos lithography process well wet etch release process sinw pressure sensor produces change voltage output external pressure applied involved experimental results show pressure sensor high sensitivity mpa range kpa nevertheless performance pressure sensor influenced temperature drift finally sake obtaining accurate complete information wide temperature pressure ranges data fusion technique proposed based back propagation neural network improved particle swarm optimization pso algorithm particle swarm optimization back propagation pso model implemented hardware using bit stmicroelectronics stm microcontroller results calibration test experiments clearly prove pso neural network effectively applied minimize sensor errors derived temperature drift
sports injuries treatment become increasingly important recent years due leisure behaviour society besides aspects acute care medical treatment often remains question optimal rehabilitative care return sports overall correct early planning rehabilitation great influence prognosis sports injuries date resumption sporting activities one key aspects consider phase dependent course rehabilitation appropriate therapy focus multidisciplinary interdisciplinary phase dependent individual treatment plan also complies biopsychosocial background athlete must created purpose increasingly relevant also sport psychological support phases rehabilitation including use cognitive behavioral therapy athlete returns sports competition objectified sport specific criteria must met
article describes new approach studying collaborative memory examines people editing processes naturally occurring memory errors approach memories individuals combined via chaining method participant indirectly receives information previous participant participants asked individually study word lists recall many words possible online setting participant completed recall task answers provided next participant suggested answers recall however participant allowed add subtract words provided list suggested answers final answer group aggregate recalled words based answer given last participant chain results showed participants displayed high accuracy recall throughout chain although able replicate entire study list eliminate errors end chain procedure advantage allows examination memory editing processes individuals utilise communicate information indirectly independent social factors arise face face group memory settings
introduction although substance abuse important clinical problem schizophrenic patients little evidence explains patients use drugs alcohol study therefore aimed examine whether premorbid personality disorders affect substance abuse methods sample included male schizophrenic patients male schizophrenic patients without substance use disorder comorbidity applied ankara numune research training hospital participant family member interviewed structured clinical interview addressed premorbid personality disorders results altogether patients group comorbidity group without comorbidity premorbid personality disorder antisocial borderline personality disorders often detected group comorbidity avoidant obsessive compulsive personality disorders less frequently found group comparing group comorbidity premorbid personality types schizophrenic patients premorbid antisocial personality disorder frequently unemployed hospitalized well earlier onset age schizophrenia respectively schizophrenic patients premorbid borderline personality disorder significantly earlier onset age substance use conclusion schizophrenic patients substance use comorbidity variously differ without comorbidity differences may associated premorbid personality disorders
dual channel satellite radio receiver solves deep fading effect specific automotive mobile environment using antenna diversity realized sige bicmos technology tuner power dissipation reduced using second zero dual conversion architecture requires lower adc sampling frequency resolution single pll drives mixers signal paths resulting smaller die area lower power dissipation providing digital baseband output allows implementation channel decode standard digital cmos process reducing overall receiver cost sdars tuner performance includes noise figure image rejection dbm input sensitivity dbm iip min gain agc range current consumption supply dual channel operation die area
intel xeon phi accelerators one newest devices used field parallel computing however comparatively studies concerning performance using existing parallelization techniques one thread level speculation technique optimistically tries extract parallelism loops without need compile time analysis guarantees loop executed parallel article evaluate performance delivered intel xeon phi coprocessor using software state art thread level speculative parallelization library execution well known benchmarks describe internal characteristics xeon phi platform particularities thread level speculation library used benchmark results show although xeon phi delivers relatively good speedup comparison shared memory architecture terms scalability relatively low computing power computational units specific vectorization simd instructions fully exploited makes first generation xeon phi architectures competitive terms absolute performance respect conventional multicore systems execution speculatively parallelized code
people frequently engage counterfactual thinking mental simulations alternative outcomes past events like simulations future events counterfactual simulations serve adaptive functions however future simulation also result various kinds distortions thus characterised adaptive constructive process approach counterfactual thinking examine whether distort memory actual events experiments young older adults imagined experiencing different scenarios participants imagined scenario engaged simulation scenario imagined counterfactual outcome subsequent recognition test participants likely make false alarms counterfactual lures novel scenarios older adults prone memory errors younger adults experiment younger older participants selected performed different actions recalled performing actions imagined performing alternative actions selected actions imagine others participants especially older adults likely falsely remember counterfactual actions novel actions previously performed findings suggest counterfactual thinking cause source confusion based internally generated misinformation consistent characterisation adaptive constructive process
facing increasing environment crisis improve energy efficiency important problem power big data main support tool realize demand side management response promotion smart power consumption distributed clean energy electric vehicles etc get wide application meanwhile continuous development internet things technology applications access endings grid power link leads large number electric terminal equipment new energy access smart grid produce massive heterogeneous multi state electricity data data produce power grid enterprise precious wealth power big data transform valuable knowledge effective operation becomes important problem needs interoperate smart grid paper researched various applications power big data integrate cloud computing big data technology include electricity consumption online monitoring short term power load forecasting analysis energy efficiency based hadoop hbase hive etc realize etl olap functions also adopt parallel computing framework achieve power load forecasting algorithms propose parallel locally weighted linear regression model study energy efficiency rating model comprehensive evaluate level energy consumption electricity users allows users understand real time energy consumption situation adjust electricity behavior reduce energy consumption provides decision making basis user intelligent industrial park example paper complete electricity management therefore future power big data provide decision making support tools energy conservation emissions reduction
high conflict divorce cases emotional toll family unit unquestionably destructive physical mental health children primary focus emotional turmoil high conflict divorce often moves focus away children parents struggle emotionally financially although best interests children always judicial purview repeated lengthy hostile litigation process often associated high conflict dissolution lasting effects physical mental health children similar associated physical abuse neglect child protective services cps must step protect emotional well children high conflict divorce cases
article presents design operational amplifier circuit austria micro systems sige bicmos technology suitable chua diodes construction connecting external passive components became basis chua circuit used example communications cryptography whole design implemented nanometer design kit mentor graphics development kit allows implement pre layout simulations also close reality post layout simulations based accurate models technology processes available manufacturer integrated circuits integrated results obtained presented article
dipyridamole infusion electrocardiographic ecg blood pressure heart rate changes seen tried investigate whether relationship hemodynamic ecg changes dipyridamole infusion gated myocardial perfusion spect findings studied consecutive patients underwent day protocol dipyridamole stress rest tcm sestamibi gated myocardial perfusion spect systolic blood pressure sbp diastolic blood pressure dbp ecg recorded mildly increased sbp dbp mildly decreased dipyridamole infusion statistically significant difference ecg changes well transient ischemic dilation tid ratio normal scans scans ischemia respectively correlation variables summed stress score sss summed difference score sds patients ischemia scans depression dipyridamole infusion also depression frequently seen patients left anterior descending artery disease patients abnormal scan depression dipyridamole infusion patient patient ischemia association tid ratio well ecg changes dipyridamole infusion sss sds coronary artery territory abnormality difference calculated left ventricular ejection fraction using stress rest images significant correlation sss sds depression dipyridamole infusion tid ratio association ischemia sss sds equivocal gated spect findings could useful interpretation
article novel scatter correction approach proposed based klein nishina formulation series deductions formulation principle proposed photon intensity distribution determined attenuation coefficient path length means pencil beams pass objects even attenuation coefficient path length objects different still achieve photon intensity distribution point spread function subsequently novel scatter correction approach established series deductions based principle simulations experiments demonstrated correctness principle comparable correction effect scatter correction approach compared beam stop array method furthermore character method program high parallel computing features dramatically increase computation speed
background low testosterone level men associated increased adiposity insulin resistance dyslipidemia whether low testosterone level associated arterial stiffness endothelial microvascular dysfunction remains unknown investigated study methods serum testosterone measured healthy men aged years endothelial microvascular function assessed brachial artery flow mediated dilation fmd digital reactive hyperemia index rhi respectively arterial stiffness evaluated tonometry derived pulse wave velocity pwv central augmentation index aix results mean total testosterone level nmol subjects low levels nmol testosterone level correlated positively rhi inversely aix fmd pwv indicating impaired microvascular hyperemia arterial elasticity lower testosterone levels multivariate adjustment framingham risk score weight testosterone level remained independent predictor rhi aix beta respectively conclusion men morbidities lower serum testosterone level associated microvascular dysfunction increased pulse wave reflections mechanisms lower testosterone levels may confer increased cardiovascular risk whether normalization low testosterone level improves vascular function needs investigation elsevier ireland ltd rights reserved
study various coatings including stabilized zro ysz films deposited cosb substrate using magnetron sputtering suppress sublimation antimony cosb thermal aging tests microstructure growth films observed using scanning electron atomic force microscopes thermal aging behavior cosb coated various films investigated accelerated experiment weight loss cosb decreased thickness coatings increasing among films ysz film suppress sublimation antimony cosb effectively compared uncoated cosb material degradation thermoelectric properties coated cosb samples decreased slowly accelerated thermal aging test
recently skin detection employed multifarious applications computer vision including face detection gesture recognition etc mainly due appealing characteristics skin color potency segment objects however certain challenges involved utilizing human complexion feature detect faces led inefficiency many methods order counteract factors paper skin segmentation method exploits multi step diffusion algorithm detect skin regions presented method starts conservative extraction skin seeds frame accomplished using fusion ternary based human motion detection modified bayesian classifier feedback mechanism subsequently candidate skin pixels utilized stage diffusion scheme detect skin pixels quantitative qualitative results demonstrate effectiveness proposed system comparison works
allergies various antibiotics reported substantial proportion patients result clinical decision support programming generates frequent warnings prescribing within electronic medical records variety reasons majority warnings may inappropriate improved understanding underlying physiology allergic processes reveals majority cross reacting antibiotic allergies implausible appropriate history taking workup invalidate many warnings electronic medical records ideally permit documentation would facilitate accurate entry eliminate similar future warnings
single phase induction motors used industry commonly induction motors expensive reason use diagnostics faults important prevents financial loss unplanned downtimes causes faults paper authors described fault diagnostic techniques single phase induction motor presented techniques based analysis thermal images electric motor authors measured analysed states single phase induction motor paper original method feature extraction thermal images called moasos method area selection states presented proposed method moasos image histogram used form feature vectors classification obtained vectors performed nearest neighbour classifier gaussian mixture models gmm described fault diagnostic techniques useful reliability single phase induction motors rotating electrical machines three phase induction motors synchronous motors motors elsevier ltd rights reserved
tnf alpha prototype member tnf family ligands pro inflammatory immune regulatory functions make appropriate therapeutic target selective blockade antibody therapy many diseases like rheumatoid arthritis using two models shuffle express cells expressed protein recognized sds page analysis ftir biospectroscopy resulted purified proteins performed mathematical calculations done identification structural conformational differences two products results showed differences disulfide bond formation beta sheet turns two recombinant proteins best knowledge first study compare secondary structure recombinant proteins conventional next generation escherichia coil based expression systems using reliable simple rapid economic atr ftir analysis whether differences might significant effects tnf alpha inflammatory immune regulatory function biological systems might much important need investigations elsevier rights reserved
background aims smooth muscle cells smcs characteristically express serum response factor srf regulates development role srf smc plasticity pathophysiological conditions gastrointestinal tract less characterized methods generated smc specific sri knockout mice characterized prenatally lethal phenotype using ultrasound biomicroscopy histological analysis used small bowel partial obstruction surgeries primary cell culture using cell specific enhanced green fluorescent protein egfp mouse lines study phenotypic molecular changes smcs immunofluorescence western blotting quantitative polymerase chain reaction finally examined srf change human rectal prolapse tissue immunofluorescence results congenital smc specific sri knockout mice died birth displayed severe cardiac defects partial obstruction resulted overall increase srf protein expression however individual smcs appeared gradually lose srf hypertrophic muscle cells expressing low levels srf also expressed low levels platelet derived growth factor receptor alpha pdgfr alpha low smcs grown culture recaptured phenotypic switch differentiated smcs proliferative pdgfr alpha low cells immediate dramatic reduction srf myh mrna expression confirmed phenotypic change human rectal prolapse tissue also demonstrated significant loss srf expression conclusions srf expression smcs essential prenatal development tract heart following partial obstruction smcs regulate srf transition proliferative pdgfr alpha low cells may represent phenotype responsible plasticity findings demonstrate srf also plays critical role remodeling process following injury
background idea undifferentiated spondyloarthritis uspa represents early undifferentiated stage ankylosing spondylitis well defined spa subtypes well known gist study assess rate estimate patients uspa evolved long term follow methods systematic search implemented identify pertinent articles primary outcome rate estimate patients uspa fulfilling diagnosis according modified new york criteria follow rate estimate corresponding confidence interval pooled random effects model stata software meta regression analyses adopted explore sources heterogeneity quality assessment conducted national institutes health quality assessment tool observational cohort cross sectional studies begg test egger test applied assess publication bias results sixteen papers finally included study screening citations pooled rate patients uspa progression synthesized papers subgroup analysis based length follow showed rate time point years follow respectively rate asia europe latin america respectively meta regression analysis indicated length follow alone accounts total heterogeneity nearly half papers scored fair quality none publication bias identified based begg test egger test line chart describes obviously increased trend patients uspa fulfilling diagnosis time conclusion progression rate patients uspa evolved variable different time point variation mostly explained length follow thus studies similar time point follow needed clarify full spectrum uspa
debate association low testosterone levels body fluids occurrence chronic periodontitis aim present systematic review assess whether low testosterone levels body fluids reflect order identify studies relevant focus question relationship low testosterone levels body fluids electronic search without time language restrictions conducted june indexed databases using different keywords periodontitis chronic periodontitis periodontal diseases testosterone gonadal steroid hormones total eight studies included present systematic review number study participants ranged male individuals ages ranging years seven studies measured testosterone levels serum two studies saliva one study gingiva four studies reported negative association serum testosterone levels two studies reported positive association decreased testosterone levels serum increased levels salivary testosterone among patients reported one study whereas one study reported significant difference concentration salivary testosterone patients without one study identified significant increase metabolism testosterone gingiva patients within limits evidence available relationship low testosterone levels remains debatable longitudinal studies control trials needed
paper discuss generate inductive invariants safety verification hybrid systems hybrid symbolic numeric method presented compute inequality inductive invariants given systems numerical invariant given system obtained solving parameterized polynomial optimization problem via sum squares sos relaxation method based gauss newton refinement rational vector recovery used obtain invariants rational coefficients exactly satisfy conditions invariants several examples given illustrate algorithm
dopamine modulate long term episodic memory potential role generation false memories however less well known randomized double blind placebo controlled experiment young healthy volunteers ingested oral dose haloperidol dopamine receptor antagonist placebo taking part recognition memory task haloperidol active study test phases experiment participants haloperidol group produced false recognition responses placebo group despite similar levels correct recognition findings show dopamine blockade healthy volunteers specifically increase false recognition memory
qualification aerospace components long costly process involving material properties material specifications manufacturing process design among others reducing qualification time cost maintaining safety offers large economic advantage enables faster response market demands darpa established open manufacturing program project develop integrated computational materials engineering icme framework aimed rapid qualification rapid qualification requires integration several technologies materials process design models monitoring control non destructive evaluation nde testing among others probabilistic design approach adopted rapid qualification process enable integration technologies single risk based function optimize design process approach directs efforts areas play important roles potentially reducing specimen testing required develop material databases design limits new tests also required validate verify icme framework develop better understanding processing microstructure property relation associated variability processing conditions probabilistic design approach demonstrated rapid qualification actual aircraft engine component constructed via powder bed additive manufacturing process paper summarizes probabilistic rapid qualification design approach application novel manufacturing process goal reducing overall qualification process time qualification process cost
diverse array nucleic acids studied several researchers management several diseases among compounds small interfering rna antisense oligonucleotides attracted considerable attention antisense oligonucleotides synthetic single stranded strings nucleic acids bind rna thereby alter reduce expression target rna sirnas hand double stranded rna molecules hybridize specific mrna sequence block translation numerous genes one main obstacles dermal transdermal delivery compounds low skin permeability review various techniques used enhance delivery molecules across skin described cases correlation enhanced dermal transdermal delivery therapeutic efficacy highlighted elsevier masson sas rights reserved
background newspaper stories impact behaviours particularly relation research participation therefore important understand narratives presented ways received work date assumes journalism transmits existing medical knowledge passive audience study aimed explore newspaper articles present stories medical research people interpret use design qualitative research methods employed analyse two data sets newspaper articles relating rheumatoid arthritis research local national news sources existing transcripts interviews patients rheumatoid arthritis carers results newspapers present positive account medical research simple narrative three essential components innovation offers hope context burden patients frequently feature passive subjects without attributed opinions articles include patients experiences research involvement patients rheumatoid arthritis carers read articles medical research critically often cynicism drawing sources interpretation conclusions understanding simple positive narrative medical research found newspaper articles may enable researchers gain mass media exposure work challenge typical style reporting critical cynical ways patients carers read stories medical research suggest concerns newspaper articles misinforming public may overstated effect research engagement unknown newspaper articles rarely present patients views experiences research conceptualized depersonalization bias
aim study explored researched area whether preterm birth bronchopulmonary dysplasia bpd affected hospitalisation rates allergies health related quality life hrqol methods studied schoolchildren born preterm mean gestational age weeks range matched term born controls mean age years range hospitalisations first discharge recorded skin prick allergy tests performed hrqol assessed parental questionnaire results preterm children hospitalised controls versus mostly two years age adjusted odds ratios two year old preterm born children hospitalised wheezing bpd affected preterm children influence hospitalisations positive skin prick rate similar preterm term born children versus preterm bpd children fewer positive skin prick tests without bpd hrqol lower preterm term children versus conclusion health problems experienced preterm born schoolchildren occurred two years age mainly wheezing disorders bpd decreased atopy influence hospitalisation rates
groundwater reservoirs important water resources world especially utmost significance arid semi arid regions therefore sustainable exploitation reservoirs needs ensured natural exclusive water supplier groundwater reservoirs saudi arabia rainfall characterized sporadic random temporal spatial distributions particularly impacts climate change giving rise uncertainty groundwater recharge quantification although saudi arabia intense frequent rainfall events rare generate significant flash floods huge amounts surface water circumstances simple effective water storage augmentation facility rainwater harvesting rwh structures gain vital importance sustainability water supply survivals arid semi arid regions objective study explore possibility rwh basin western province saudi arabia called wadi lith climate change climatic data obtained ipcc gcms downscaled using regional climate model regcm arabian peninsula domain regcm driven simulate climatic parameters including rainfall grid resolution present climate future climate representative concentration pathways rcp rcp results indicate durable longer wet durations expected increasing surplus rainfall amounts far future climate change impacts consequently future climate scenarios expected enhance floods flash floods occurrences call progressive measures harness rwh opportunity elsevier rights reserved
among children visiting child adolescent mental health care cam prevalence exposure family violence reported exceed prevalence community samples potentially traumatic interpersonal events ipe outside family aim study relate cam patients self reported experiences violence exposure current psychiatric symptoms compare patients exposed violence patients reported exposure asked consecutive year old patients cam current previous exposure violence outside family prevalence exposure kind violence reported exposures ipe children exposed ipe negatively affected events children exposed ipe children ipe group reported mental health symptoms violence group general ipe related outcome measures combination degree violence exposure seemed dose response relationship diagnosis post traumatic stress disorder
trajectories parental involvement time engagement child care across months postpartum associations parents partners psychological adjustment dysphoria anxiety empathic personal distress examined using sample dual earner couples experiencing first time parenthood couples using time diary measures captured intensive parenting moments hierarchical linear modeling analyses revealed patterns associations psychological adjustment parental involvement time depended parenting domain aspect psychological adjustment parent gender psychological adjustment difficulties tended bias parent system toward gendered pattern mother step father step father involvement tended decrease mother involvement either remained unchanged increased response partners psychological adjustment difficulties contrast significant effects found models using parental involvement predict psychological adjustment
purpose paper analyze construction model urban fanning vertical building envelopes support green building development sleman regency special district yogyakarta province indonesia construction vertical buildings sleman district growing rapidly together increasing demand provision housing public facilities rapid physical development sleman caused reduction green land green open space rth agricultural land rice fields developments potentially threaten food security sleman district urban farming method agricultural activities reduce problems agricultural land limitation urban areas like sleman district construction design model urban farming vertical building envelope one aspect green building support efforts vertical farming processes showed method require horizontally ground space effectively used vertical space building envelope including wall building roof features construction fact urban farming construction method contribute productive agricultural activities also support greening urban area well reduce crisis agricultural land issues urban farming construction model vertical building facade includes urban farming construction roof wall balcony authors published elsevier ltd
background children exposed flame retardants built environment brominated diphenyl ethers bde organophosphate based flame retardants opfrs associated poorer neurocognitive functioning children less known however association classes compounds children emotional social behaviors objective study determine flame retardant exposure associated measurable differences social behaviors among children ages years methods examined teacher rated social behaviors measured using social skills improvement rating scale ssis personal exposure flame retardants children aged years attended preschool silicone passive samplers worn days used assess personal exposure compounds using gas chromatography mass spectrophotometer concentrations summed total bde total opfr exposure prior natural log transformation separate generalized additive models used evaluate relationship seven subscales ssis lnsbde lnsopfr adjusting age sex adverse social experiences family context results children exposed mixture flame retardant compounds observed dose dependent relationship sigma opfr two subscales children higher exposures rated preschool teachers less responsible behavior externalizing behavior problems additionally children higher sigma bde exposure rated teachers less assertive conclusions observed cross sectional association children exposure flame retardant compounds teacher rated social behaviors among preschool aged children children higher flame retardant exposures exhibited poorer social skills three domains play important role child ability succeed academically socially
aims characterize clinicopathological genetic features pleomorphic mantle cell lymphoma pmcl morphologically mimics diffuse large cell lymphoma dlbcl methods results screened systematically cell lymphomas morphologically compatible dlbcl using immunohistochemical algorithm three markers cyclin sox ten cases pmcl identified study surprisingly four cyclin negative patients mainly elderly males advanced disease median survival months cyclin positive pmcls tested showed igh ccnd translocation whereas one four cyclin negative pmcls translocation involving ccnd high ccnd mrna level genomewide copy number profiles cyclin positive cyclin dnegative pmcls similar classical mantle cell lymphoma mcl reported previously confirming diagnosis secondary genetic alterations involved oncogenic pathways mcl observed frequently pmcls possibly decreasing dependence driving ccnd translocation accounting common cyclin negativity copy number gains pikca ccdc detected cyclin negative pmcls cyclin positive pmcls additional oncogenic signals may compensate common absence ccnd translocation cyclin negative pmcl conclusion demonstrate first time cyclin negativity surprisingly common pmcl morphologically mimicking dlbcl use simple immunohistochemical algorithm prevent misclassification inappropriate treatment
presence traffic slender long span bridge deck modify cross section profile bridge may influence flutter derivatives turn critical flutter wind velocity bridge studies influence vehicles flutter derivatives critical flutter wind velocity bridges rather rare compared investigations coupled buffeting vibration wind vehicle bridge system typical streamlined cross section long span bridges adopted experimental analytical studies scaled bridge section model vehicle models distributed bridge deck considering different traffic flow scenarios tested wind tunnel flutter derivatives modified bridge cross section identified using forced vibration method results suggest influence vehicles flutter derivatives typical streamlined cross section ignored based identified flutter derivatives influence vehicles flutter stability bridge investigated results show effect vehicles flutter wind velocity obvious
role endocannabinoid system nicotine addiction increasingly acknowledged acute inhibition anandamide aea degradation efficiently reduces nicotine withdrawal induced affective symptoms rats fatty acid amide hydrolase faah degradation enzyme aea proposed possible treatment nicotine addiction however unclear whether chronic inhibition aea nicotine abstinence beneficial deleterious affective side effects using rat model nicotine addiction found abstinence rats injected daily faah inhibitor urb developed depressive like phenotype results show nicotine abstinent rats urb induced low saccharin consumption persistent immobility forced swim test increased corticosterone levels response stress addition urbdecreased receptor binding activity habenula key structure control nicotine related emotional states contrast non treated abstinent rats showed increased receptor activity behaviors comparable controls faah inhibition induced alterations observed animals previous history saline self administration taken together results suggest chronic faah inhibition prevents homeostatic adaptations habenular receptor function necessary recovery nicotine dependence elsevier ltd rights reserved
mycobacterium avium ssp paratuberculosis map causative agent johne disease chronic inflammatory bowel disease cattle characterized intermittent chronic diarrhea addition map isolated crohn disease patients impact map severity clinical symptoms well role yet unknown previously shown map able colonize inflamed enteric tissue exacerbate inflammatory tissue response suwandi present study analyzed repeated map administration influences course dextran sulfate sodium dss induced colitis comparison mice exposed dss map repeated exposure dss treated mice map dss map revealed significantly enhanced clinical score reduction colon length well severe cell infiltration colonic lamina propria functional analysis identified critical role cells map induced disease exacerbation additionally altered immune responses observed closely related mycobacteria species avium ssp avium avium ssp hominissuis administered data reveal specific ability ofmap aggravate intestinal inflammation clinical symptoms overall phenotype compatible similar disease promoting capabilites map
aimsto investigate possible effects food drug administration fda public health notifications regarding surgical trends transvaginal mesh tvm placement stress urinary incontinence sui related mesh revision surgery female pelvic medicine reconstructive surgery fpmrs practice tertiary care academic medical centers united states methodssurgical volume procedures performed primarily fpmrs surgeons eight academic institutions across collected using current procedural terminology cpt codes stress urinary incontinence repair revision surgeries sas statistical software used assess trends data resultsthere decrease use synthetic mesh sling treatment sui academic tertiary care centers past years however statistically significant total number surgical interventions sui remained stable increase utilization autologous fascia pubovaginal slings afpvs number mesh sling revision surgeries including urethrolysis removal revision slings increased almost three fold centers conclusionsthese observed trends suggest possible effect fda public health notifications regarding tvm surgical practice sui academic centers even though specifically warn use synthetic mesh indication indications surgery complications outcomes evaluated retrospective study however data may provide alternative insights reasons observed trends neurourol urodynam wiley periodicals inc
background resveratrol curcumin natural flavones products good therapeutic effect acute chronic inflammation hand tetramethylpyrazine tmp angiogenesis vessel protection effect well anti inflammatory function paper anti inflammatory effect tetramethylpyrazine resveratrol curcumin trc combination acute chronic inflammation reported vivo methods dose combined three natural products optimized based acute paw swelling mouse model uniform design methodology therapeutic effect trc combination chronic inflammation investigated using collagen induced arthritis cia rat model based upon following indexes volume paw swelling arthritis score serum mediators histological examination well immunohistochemical staining levels alanine aminotransferase alt aspartate transaminase ast serum measured pathological sections liver kidney analysed measured based acute oral toxicity aot standard method results best formulation three components combined mass proportion revealed uniform design methodology combination could significantly reduce paw swelling acute paw swelling mouse model could reduce paw swelling alleviate damage joint structural ankle cartilages fibrous tissue cia rat model dose relationship clear cases immunohistochemical staining ankle tissue revealed trc combination able inhibit expression kappa tnf alpha closely related inflammatory process analysis serum mediators revealed trc combination could inhibit production tnf alpha beta serum toxic study revealed formulation low toxic larger level alt ast histopathology liver kidney exhibited distinctions trc combination blank group mortality occurred administered doses conclusions results showed formulation could provide novel potent treatment acute chronic inflammation without side effect like gastric injury occurring nsaids
object detection one important tasks computer vision usually performed evaluating subset possible locations image likely contain object interest exhaustive approaches superseded object proposal methods interplay detectors proposal algorithms fully analyzed exploited although relevant problem object detection video sequences propose connect closed loop detectors object proposal generator functions exploiting ordered continuous nature video sequences different tracking require previous frame improve proposal detection prediction based local motion performed thus avoiding tracking errors obtain three four points improvement map detection time lower faster regions cnn features cnn fastest convolutional neural network cnn based generic object detector known moment
schizophrenia associated severe cognitive deficits including impaired working memory neural mechanismthatmay contribute towmimpairment disruption excitation inhibition balance cortical microcircuits remains unknown however alterations map onto quantifiable behavioral deficits patients based predictions validated microcircuit model spatial hypothesized two key behavioral consequences increased variability wmtraces time reducing performance precision decreased ability filter distractors overlapwithwmrepresentations testmodel predictions studied schizophrenia patients matched healthy comparison subjects hcs performed spatialwmtask designed test computational model specifically manipulated delay duration distractor distance presented delay subjects used high sensitivity joystick indicate remembered location yielding continuous response measure results largely followedmodel predictions whereby patients exhibited increased variance less precision delay period increased relative hcs schizophrenia patients also exhibited increasedwmdistractibility reports biased toward distractors specific spatial locations predicted model finally magnitude thewm drift distractibility significantly correlated indicating possibly shared underlying mechanism effects consistent elevated ratio schizophrenia establishing framework translating neural circuit computational model cognition human experiments explicitly testing mechanistic behavioral hypotheses cellular level neural deficits patients published elsevier
new deterministic model hiv aids incorporates pre exposure prophylaxis prep designed used assess population level impact use prep transmission dynamics disease within msm population conditions effective control elimination persistence hiv aids msm population determined rigorously analyzing model uncertainty sensitivity analysis carried using data relevant hiv transmission dynamics msm community state minnesota determine effect uncertainties parameter values outcome response variable associated reproduction number identify parameters effect disease transmission dynamics numerical simulations show current rate administration antiretroviral treatment hiv infected individuals hiv burden decreases increasing prep coverage furthermore setting study suggests hiv effectively controlled msm population addition current rate administration anti retroviral therapy community least mean susceptible members msm community prep adjusted prep efficacy elsevier inc rights reserved
dual education effective integration control theory practical experience providing ideal start improve professional career students many technical universities important benefits brings students industrial partners practical training industry companies opportunity acquire practical skills modern industrial plants production equipment well feel employed learn requirements culture companies time students great chance offered job still studies paper presents modern form study focus development control methods control structures ict applications different types industrial processes since emergence late mechatronics become well established academic subject researched taught large number worldwide universities research institutions try get heart multidisciplinary engineering mechatronics excellent example point integration disciplines leads new degrees freedom corresponding dual form education connection industrial partners ifac international federation automatic control hosting elsevier ltd rights reserved
reconstructive nature autobiographical memory subject range distortions one distortion involves erroneous incorporation features one episodic memory another forming known memory conjunction errors healthy aging associated enhanced susceptibility conjunction errors laboratory stimuli yet unclear whether findings translate autobiographical domain investigated impact aging vulnerability conjunction errors explored potential cognitive processes underlying formation errors imagination recombination paradigm used elicit conjunction errors young older adults participants also completed battery neuropsychological tests targeting relational memory inhibition ability consistent findings using laboratory stimuli older adults susceptible conjunction errors younger adults however older adults differentially vulnerable inflating effects imagination individual variation conjunction error vulnerability attributable inhibitory capacity inability suppress cumulative familiarity individual details appears contribute heightened formation conjunction errors age
aimthe aim study evaluate management outcomes advanced pelvic organ prolapse pop nulliparous women methodseight nulliparous women diagnosed pop stage january august according pelvic organ quantification system popq reviewed seven managed surgically one managed pessary primary outcome surgical objective cure pop subjective cure defined negative response questions pelvic organ prolapse distress inventory secondary outcomes complications symptoms severity quality life according validated questionnaires resultsa total prolapse patients pop stage managed surgically among seven nulliparous woman least one risk factor associated pop risk factors identified history pelvic trauma obesity menopause chronic cough hard physical labor constipation five patients underwent surgical correction vaginal hysterectomy sacrospinous fixation mesh perigee avaulta two patients uterine preservation without mesh hysteropexy sacrospinous ligament fixation one patient preferred treatment pessary total cure rate objective subjective cure rates surgical reconstructive surgery conclusionmanagement nulliparous advanced pop poses significant challenges regard uterine preservation future pregnancy childbirth conservative management pessary insertion offered followed surgical correction reconstructive surgery mesh may improve prolapse symptoms objectively subjectively
goes without saying use fido based services especially financial areas becoming widespread days fido services adapting variety service areas easy payment money transfer atm withdrawal savings single sign etc fido service uses standard public key cryptography techniques provide stronger authentication securely saves users bio information smartphone registered fido confirms match preenrolled fingerprints one registration process words fido able verify persons identity user register biometric information sites purpose solve problems implementing fido pki technologies adapted current fido service accredited certification system proposed secure biometric authentication framework provides centralized biometric authentication framework fintech environment variety services need interoperability users biometric information order protect users privacy increase convenience customers
permanent community based housing supportive services supported housing numerous favorable outcomes homeless experienced consumers little known however consumers attain subsequently lose supported housing using mixed methods compared persons retained supported housing least year stayers lost supported housing within year move exiters among persons housed supported housing vash program greater los angeles queried homeless registry data identify stayers exiters reviewed medical records randomly selected stayers exiters compare demographics homelessness chronicity era service income presence absence serious mental illness health service utilization subsample purposively selected stayers exiters semistructured qualitative interviews detailed medical record review also performed qualitative interviews focus groups vash staff leadership recursive partitioning identified quantitative variables best differentiated stayers exiters thematic analyses performed qualitative data interrelated factors associated exiting supported housing chronic homelessness low intrinsic motivation unmet needs mental health care substance abuse treatment independent living skills poor primary care engagement frequent emergency department use recent mental health hospitalizations findings suggest value clinical interventions address factors example motivational interviewing social skills training adapted setting context supported housing
objectives evaluate compare efficacy tamsulosin day combinations trospium twice day treatment single small lower ureteral stones patients methods total patients presenting urology outpatient clinics july may single sized lower ureteral stone randomly classified two treatment groups patients group received oral dose tamsulosin daily trospium chloride twice daily patients group received tamsulosin daily placebo twice daily spontaneous passage stones stone expulsion time adverse effects evaluated results significant differences baseline characteristic patients groups stone expulsion observed patients groups respectively average time expulsion days group days group spontaneous stone passage rate ureter significantly higher stone expulsion time faster groups group adverse effects observed groups comparable mild
paper circuit design fractional order proportional integrated derivation pid controller synchronization different chaotic systems described chaotic synchronization control used different applications nonlinear physical systems performance tests controllers chaotic communication systems chaotic systems created synchronization control two systems carried using pid controller total square error minimized order determine parameters orders designed controller circuit results obtained using controller better obtained using classical control systems using pid controller time reach synchronization decreased significantly
background aim non invasive detection monitoring inflammatory bowel disease ibd important clinical challenge stool calprotectin popular among available options necessity stool collection limits acceptability study aimed evaluate biomarker measurement non invasively collected colorectal mucus new tool ibd detection activity monitoring methods calprotectin eosinophil derived neurotoxin edn protein measured colorectal mucus self collected following defecation patients ibd therapy patients irritable bowel syndrome healthy volunteers patients ibd also collected samples days treatment disease activity monitoring results protein biomarker levels significantly higher ibd patients irritable bowel syndrome control groups calprotectin edn effectively detected ibd respective sensitivity specificity calprotectin edn less sensitive calprotectin edn results combined new test caledn sensitivity specificity repeated biomarker measurement ibd treatment demonstrated steady decline calprotectin edn levels well caledn values patients responding applied therapy lack pattern non responders conclusions measuring calprotectin edn non invasively collected colorectal mucus presents simple efficient method ibd detection monitoring excellent performance edn purpose reported first time combining calprotectin edn one test improves ibd detection sensitivity
laser heating technology type potential attractive space heat flux simulation technology characterized high heating rate controlled spatial intensity distribution rapid response however controlled plant nonlinear time varying uncertainty implementing laser based heat flux simulation paper novel intelligent adaptive controller based proportion integration differentiation pid type fuzzy logic proposed improve performance laser based ground thermal test temperature range thermal cycles many instances order improve adaptability controller output scaling factors real time adjusted thermal test underway initial values scaling factors optimized using stochastic hybrid particle swarm optimization pso algorithm validating system established laboratory performance proposed controller evaluated extensive experiments different operating conditions reference load disturbance results show proposed adaptive controller performs remarkably better compared conventional pid pid controller conventional pid type fuzzy pid controller considering performance indicators overshoot settling time steady state error laser based ground thermal test reliable tool effective temperature control laser based ground thermal test chinese society aeronautics astronautics production hosting elsevier ltd open access article license
jellyfish uses jet propulsion achieve diversity propulsion modes water article miniature jellyfish inspired swimming robot designed built capable executing horizontal vertical propulsion maneuvers order imitate jellyfish terms morphology kinematics robotic jellyfish designed comprised streamlined head cavity shell four separate drive units bevel gears soft outer skin encasing drive units combination four six bar linkage mechanisms centrally symmetric adopted driver regulate phases contraction relaxation bell shaped body furthermore triangle wave generator incorporated generate rhythmic drive signals implemented microcontroller independent coordinated control four drive units robotic jellyfish able replicate various propulsion modes similar real jellyfish aquatic tests actual robot verify effectiveness formed design scheme along proposed control methods
implementation anticipating driving styles adaptive cruise control systems promises considerably reduce fuel consumption vehicles drivers accept optimised driving styles systems implement longitudinally automated driving optimisation results deviate strongly average driving behaviour work presents approach optimisation vehicle longitudinal dynamics based predicted average driving profile proposed approach ensures optimisation results meet expectations drivers directly accounting driver preferences weighting travel time fuel consumption relative average driving profile based human decision finding rational intuitive planning decisions modelled cost function represent optimisation constraints approach generally includes information vehicle vehicle vehicle infrastructure communication extension state art study describes optimisation approach presents method determine suitable optimisation parameters order consider driver preferences optimisation approach applied simulated test drive improvements fuel economy analysed finally authors sketch reference system architecture prove feasibility presented approach
understanding spatial temporal characteristics water flux shallow aquifers imperative water resources management eco environmental conservation study spatial variability vertical specific fluxes hydraulic conductivities streambed evaluated integrating distributed temperature sensing dts data vertical hydraulic gradients ensemble kalman filter enkf smoother enks empirical thermal mixing model formulation enkf enks assimilation scheme based discretized advection conduction equation heat transfer streambed first systematically tested synthetic case performed quantitative statistical analyses evaluate performance assimilation schemes real world case evaluated calculate assimilated specific flux initial estimate spatial distributions vertical hydraulic gradients obtained empirical thermal mixing model steady state conditions using constant vertical hydraulic conductivity initial estimate updated repeatedly dividing assimilated specific flux estimates vertical hydraulic gradients obtain refined spatial distribution vertical hydraulic gradients vertical hydraulic conductivities results indicate optimal parameters derived fewer iterations greater simulation effort using enks compared enkf field application stream segment heihe river basin northwest china average vertical hydraulic conductivities streambed varied three orders magnitude specific fluxes ranged near zero vertical hydraulic gradients within range highest variable fluxes occurred adjacent debris dam bridge pier phenomenon likely result heterogeneous streambed hydraulic characteristics areas results significant implications hyporheic micro habitats fish spawning wildlife incubation regional flow hyporheic solute transport models heihe river basin well similar hydrologic settings
paper investigate case ambiguous shape reconstruction two light source photometric stereo based illuminating unknown lambertian surface far problem merely well understood two linearly independent light source directions one illumination assumed overhead already established necessary sufficient condition disambiguate entire shape reconstruction process controlled satisfaction corresponding second order linear pde constant coefficients two independent variables work extends latter arbitrary pair light source directions transforming constraint special nonlinear pde addition similar ambiguity analysis also performed special configuration two light source directions assumed time orthogonal contained vertical plane finally work supplemented illustrative examples exploiting symbolic computation used within framework continuous reflectance map model image irradiance equation applied genuine lambertian surfaces
rating relevance words imagined situation stranded grasslands without survival material leads exceptionally good memory words survival processing effect received much attention promises elucidate evolutionary foundations memory however proximate mechanisms survival processing effect identified informed speculations adaptive function possible test contrast promising accounts survival processing effect according account effect consequence prioritized processing threat related information according account thinking relevance items survival stimulates thinking object function particularly elaborate form encoding experiment showed emotional properties survival scenario manipulated negative positive framing scenario influence recall focus threat encoding led worse recall focus function latter finding replicated experiment showed focusing threat lead memory advantage pleasantness control condition beneficial effect inducing functional focus encoding even surpasses standard survival processing instruction together results support theory thinking function important component survival processing effect
background nurses working northern australia radiation therapy unit advise patients undergoing radiation therapy use readily available nonprescription moisturizing cream minimize severity radiation skin reactions however patients report cream thick difficult use humid tropical climate nurses anecdotally suspect increase severe skin reactions summer months objective article presents protocol randomized controlled trial addressed lack evidence pertaining use topical creams prevent acute radiation skin reactions tropical climate methods two skin care creams used trial trial primary outcome measure incidence moist desquamation treatment month treatment completion secondary outcome participants acceptance allocated cream similar time points results recruitment trial completed findings research reported separate publication conclusions article presents protocol randomized controlled trial addresses lack evidence pertaining use topical creams prevent acute radiation skin reactions tropical climate implications practice protocol adapted researchers conducting practice based research
swipe detector ballon borne mission lspe see contribution bernardis conference intends measure primordial mode polarization cosmic microwave background cmb scope microwave telescopes need sensitive cryogenic bolometers overall equivalent noise temperature range detector spiderweb bolometer based transition edge sensor followed squid perform signal readout contribution concentrate design description first tests front end electronics processes squid output controls squid output first amplified low noise preamplifier based discrete jfet input differential architecture followed low noise cmos operational amplifier equivalent input noise density bandwidth extends least mhz devices jfet cmos amplifier tested liquid nitrogen second part contribution discuss design results control electronics flux locked loop squid slow control chain monitor set system reviewed digital interface control computer presented
article propose novel framework modelling non stationary multivariate lattice processes approach extends locally stationary wavelet paradigm multivariate two dimensional setting framework develop permits estimation spatially localised spectrum within channel interest importantly localised cross covariance describes localised coherence channels associated estimation theory also established demonstrates multivariate spatial framework properly defined suitable convergence properties also demonstrate model based approach successfully used classify range colour textures provided industrial collaborator yielding superior results compared current state art statistical image processing methods
canada faces environmental problems threaten stock natural capital endowment natural resources water forests land atmosphere flow goods services natural capital generates known ecosystem services much literature focuses climate change greenhouse gas emissions many challenges persist including air water pollution risks oil gas extraction water scarcity flooding loss natural areas threatened species toxic spills regulatory responses exist effectiveness questionable relatively little use market based instruments focus challenges associated measuring developing policy sustain natural capital ecosystem services highlight problems identify policy options big ideas may help improve understanding linkages natural capital ecosystem services human well achieve sustainable future
materials assembled layer layer lbl assembly vacuum assisted flocculation vaf similarities systematic study comparative advantages disadvantages missing study needed practical fundamental perspectives aiming better understanding structure property relationships nanocomposites purposeful engineering materials unique properties layered composites polyvinyl alcohol pva reduced graphene made techniques comparatively evaluate structure mechanical electrical properties lbl vaf composites demonstrate clear differences atomic nanoscale structural levels reveal similarities micrometer submicrometer organization epitaxial crystallization suppression phase transition temperatures pronounced pva lbl vaf composites mechanical properties virtually identical assemblies high contents conclude mechanical properties layered assemblies largely determined thermodynamic state pva polymer nanosheet interface rather nanometer scale differences packing high nearly identical values toughness lbl vaf composites reaching observed thermodynamically optimal composition confirm conclusion toughness highest among layered assemblies cellulose clay etc electrical conductivity however higher lbl vaf composites contents electrical properties largely determined tunneling barrier sheets therefore strongly dependent atomic nanoscale organization findings open door application oriented methods materials engineering using types layered assemblies
dynamic tensile strength materials load durations microseconds less studied analyzing spall phenomena shock pulse loading paper devoted discussing methodology capabilities technique measure spall strength error sources spall fracture materials different classes factors governing high rate fracture metals alloys conditions
theorists post capitalism recently argued less inevitable end capitalism assume private accumulation systematically blocked inability capitalist corporations create revenues setting prices lose control reproduction commodities process capitalist labour eventually disappear drawing case study amazon thoughts policies leading digital corporations challenge assumptions key corporate players digitization trying become powerful monopolies partly succeeded using network effects scaling opportunities digital goods building socio technical ecosystems strategies led development part isomorphic structures hence creating situation oligopolistic market competition draw basic assumptions monopoly capital theory argue situation labour process rationalization becomes key corporation competitive strategies see expansion digital control organizational structures applied key corporate players digital economy evidence expansion capitalist labour reduction
snow accumulation ablation runoff mountainous areas critical components hydrologic cycle poorly known passive microwave measurements sensitive snow water equivalent swe even mountain regions vegetation masks microwave signals reduces sensitivity study examines snow signal affected forest density fourteen basins sierra nevada usa series sixteen subsets kern basin varied vegetation density ghz vertical polarization brightness temperature time series basin produced spaceborne amsr operational period water year basin coefficient determination annual minimum concurrent swe calculated evaluate sensitivity swe relationship values forest density analyzed assess vegetation affect swe information observed mean forest coverage modis used represent forest density annual minimum concurrent swe three basins consistent previous studies demonstrated anomalous values many basins apparently due anomalous warm winter rainfall excluding significantly higher basins eight fourteen basins basins average elevation swe correlates well decreases monotonically decreasing elevation basin elevation forest cover highly correlated sierra basin elevation generally coincides forest cover total sierra nevada forest cover corresponds estimated total swe sierra thus swe empirically correlated third swe sierra typically high elevations treeline elsevier inc rights reserved
paper examines long run employment consequences experiencing homelessness childhood rather later life use novel panel data link survey administrative data sample disadvantaged adults homeless risk homelessness estimation approach pays particular attention potential pathways linking childhood homelessness adult employment find experiencing homelessness first time children less likely employed women relationship largely explained lower educational attainment higher welfare receipt general form mental illness related disability payments experiencing childhood homelessness higher rates high school incompletion incarceration explain link childhood homelessness men employment however childhood homelessness continues substantial direct effect male employment rates
objective progressive multifocal leukoencephalopathy pml emerging complication immunosuppressive therapies especially natalizumab multiple sclerosis factors associated functional outcome natalizumab associated pml natalizumab pml sufficiently described methods retrospectively analyzed medical records patients natalizumab pml treated hospital since disability measured expanded disability status scale edss two different time points highest available edss pml last available edss pml diagnosis served functional outcome parameters clinical laboratory imaging data analyzed association functional outcome applying spearman rho multivariate regression analysis results patients survived pml poor functional outcome associated higher age higher initial john cunningham virus jcv copy number cerebrospinal fluid csf extensive pml lesions initial magnetic resonance imaging mri association functional outcome duration natalizumab therapy delayed pml diagnosis observed conclusion study useful neurological practice estimate functional outcome disease severity natalizumab pml primary care settings
becoming responsible teen bart community based hiv risk reduction curriculum shown increase safer sex behaviors among african american adolescents however bart address common barriers sexual health care access may limit program efficacy used community engaged adaptation process maximize program relevance health outcomes incorporating broad ecological perspective adolescent staff advisory boards community based organization recommended modifications delete references kwanzaa update language localize incentives supported inclusion critical site health services sexually transmitted infection testing condom provision conducted trial adapted bart one session week weeks adolescents two community organizations mean age years female reported previous sexual intercourse received site sexually transmitted infection testing condoms adolescents demonstrated significant improvements self efficacy safer sexual practices aids risk knowledge condom knowledge condom attitudes adolescents staff satisfied revised curriculum found site services acceptable based improvements constructs influencing behavior successful delivery services essential optimal health future studies assess efficacy sustainability adapted curriculum appear warranted
aim study evaluation specificity sensitivity skin prick tests spts specific ige atopy patch tests apts atopic dermatitis patients suffering food allergy total patients examined complete dermatological allergological examination performed patients food allergy confirmed peanuts patients egg patients soy patients wheat patients cow milk patients specificity spt specific ige apt considered good sensitivity apt low positive results isolation confirm food allergy however together diagnostic methods clinical history open exposure test tests valuable tool examination food allergy
silkworm infection model potential replace conventional animal models evaluation efficacy toxicity investigational antifungal agents silkworms relatively inexpensive simply grown large numbers easily infected pathogenic fungi including mutant strains antifungal agents injected silkworm either via hemolymph mimic intravenous administration directly gut oral administration antifungal effect evaluated common features regarding mechanisms pharmacokinetics silkworm mammals result consistent therapeutic effectiveness antifungal agents asp promising new antifungal agent discovered using silkworm model conclusion silkworms ethical less expensive alternative standard animal models particularly identification testing new antifungal agents
cerebral wall human fetal brain composed transient cellular compartments show characteristic spatiotemporal relationships intensity major neurogenic events cell proliferation migration axonal growth dendritic differentiation synaptogenesis cell death myelination aim present study obtain new quantitative data describing volume surface area thickness transient compartments human fetal cerebrum forty four postmortem fetal brains aged postconceptional weeks pcw included study high resolution weighted images acquired fetal brain hemispheres images processed using house software mni ace toolbox delineation fetal compartments performed semi automatically registration mri histological sections brains age matched brains zagreb neuroembryological collection growth trajectories transient fetal compartments reconstructed composition telencephalic wall quantitatively assessed pcvv intensity neuronal proliferation decreases drastically relative volume proliferative ventricular subventricular compartments showed pronounced decline contrast synapse extracellular matrix rich subplate compartment continued grow first two trimesters occupying telencephalon reaching maximum volume thickness around pcw developmental maximum coincides period intensive growth long cortico cortical fibers enter wait subplate approaching cortical plate although find significant age related changes mean thickness cortical plate volume gyrification index surface area cortical plate continued exponentially grow last phases prenatal development cortical expansion coincides developmentally transformation embryonic cortical columns dendritic differentiation ingrowth axons results provide quantitative description transient human fetal brain compartments observable mri moreover improve understanding structural functional relationships brain development enable correlation vitro vivo imaging fine structural histological studies serve reference study perinatal brain injuries
minimal mass ultra lightweight high packaging efficiency stowage volume important factors associated space technology hence become attractive traits getting larger bandwidth satellites orbit nowadays maintaining surface shape pre tension membranes instrument precision become challenging problem hence membrane reflectors receiving increasing attention mission architectures need extremely large space deployable antennas paper presents finite element investigation rectangular flat thin membrane using polyvinylidene fluoride pvdf piezo actuated material actuator sensor passive effect pvdf dynamics inflatable space based rectangular shaped structure studied trends natural frequencies various patch areas thickness explored investigation shows rather using various numbers patches practical system controlling vibration behavior single patch appropriate thickness easily control desired vibration behavior therefore concluded discrete sensor actuators devices preferred realize lower weight effective control authority modest values actuator voltages active vibration control practical structures
paper presents weakly coupled formulation electromagnetic thermal fields applying backward differentiation formula bdf theta algorithm adaptive time stepping variable order finite element discretization coupling electromagnetic diffusion equation ede electrical circuit equations also included minimum time step criterion adopted algorithm time step size order selection implemented proposed model programmed language example presented show application formulation
due efficiency revitalized traditional techniques irrigation management scarce water resources suggested way least partially cope present water crises middle east better irrigation management includes using treated wastewater agriculture treated wastewater also used industrial processes thus contributing efficient overall water management however important change leading better water management improving water efficiency agricultural irrigation traditional water management techniques important role many middle east north african mena countries besides bringing water thirsty population also contribute societal awareness recognition great diversity cultural social values water human civilization
temporal logic model checking verification method describe system model verify whether important properties expressed temporal logic formula hold system many model checking tools employ bdds data structure represent sets states empirically observed bdds used algorithms may grow exponentially model formula increase size formally prove kind data structure polynomial size represent set valid initial states models formulae result holds data structures state checked polynomial time therefore holds types bdds regardless variable ordering also powerful data structures rbcs mtbdds adds sdds thus size explosion bdds limit specific data representation structures unavoidable every formalism used way would lead exponential size blow
paper studies stochastic behavior signed variants lms algorithm system identification framework input signal cyclostationary white gaussian process three algorithms studied signed regressor signed error sign sign algorithms input cyclostationary signal modeled white gaussian random process periodically time varying power system parameters vary according random walk mathematical models derived mean mean square deviation behavior adaptive weights input cyclostationarity models used derive new results concerning performance algorithms results surprising monte carlo simulations three algorithms provide strong support theory
surface plasmon grating couplers optimized separately characterizing collection efficiency rescattering transmission effects isolated grating elements finite difference time domain methods using signal flow graph methods assess performance arrays identical elements small bars ridges trenches silver wavelength shown different coupling patterns efficiencies near zero physical width element overall efficiency requires suitable trade coupling surface wave transmission example structure exhibiting equivalent capture length ten wavelengths shown
paper complete sensitivity analysis optimal parameters axial flux permanent magnet synchronous machines working field weakening region implemented thanks presence parameterized accurate analytical model possible obtain required parameters machine two goals ideal design maximize power density density ratio maximal rated speed max inductance related parameter keeping efficiency target speed different slots poles phases combinations studied reveal optimum combination phase paper studied effect ratio number stator slots number rotor poles density max shown low value parameter results better density max effect outer diameter inner outer diameter ratio studied respect two design goals addition comparison finite theoretical infinite speed designs implemented complete finite element validation proven robustness analytical model
purpose review current literature prevalence cataract hispanic females living united states methods review relevant literature cataract eye disease health practices hispanics living results females comprise blind persons worldwide internationally female gender associated lower awareness cataract diseases eye women less likely cataract surgery men low middle income countries conclusion hispanic women receive disparate care compared male counterparts etiology likely multifactorial possible contributors include genetics gender roles personal healthcare decisions interventions address disparity targeted efficient sustainable
drying uniformity one important indicators evaluating drying technique well final quality dried products current study three drying approaches hot air drying microwave vacuum drying mvd combined method mvd applied dehydrate mango slices mvd process time required hot air drying determined terms colour variations hotair drying help hyperspectral imaging conjunction multivariate data analysis image processing moisture content distribution mango slices subjected different drying methods visualised results showed non uniform drying property mango slices dried mvd individually dried samples higher moisture content centre mvd dried samples showed opposite result drying uniformity improved mvd combined produced dried products even moisture distribution mango slice samples dried mvd showed porous structure high percentage colour retention current study led development effective combined mvd technique enhancing drying uniformity industry iagre published elsevier ltd rights reserved
numerous studies reported time perception temporal processing impaired schizophrenia meta analytical review differentiate time perception judgments time intervals basic temporal processing judgments temporal order well effects accuracy deviation estimates veridical value precision variability judgments meta regression approach also included specific tasks different time interval ranges covariates considered publications past years meta analyzed data patients schizophrenia healthy control participants independent tasks interval durations results demonstrate time perception basic temporal processing less precise variable patients hedges whereas effects schizophrenia accuracy time perception rather small task dependent review also shows several aspects potential influences medication yet investigated sufficient detail conclusion results accordance theoretical assumptions notion variable internal clock patients schizophrenia strong effect schizophrenia clock speed impairment temporal precision however may also clock unspecific part general cognitive deficiency schizophrenia
surveying endangered species necessary evaluate conservation effectiveness camera trapping biometric computer vision recent technological advances impacted methods applicable field surveys methods gained significant momentum last decade yet researchers inspect footage manually studies used automated semantic processing video trap data field particular aim study evaluate methods incorporate automated face detection technology aid estimate site use two chimpanzee communities based camera trapping comparative baseline employ traditional manual inspection footage analysis focuses specifically basic parameter occurrence assess performance practical value chimpanzee face detection software found semi automated data processing required time compared purely manual analysis non negligible increase efficiency critical assessing feasibility camera trap occupancy surveys evaluations suggest methodology estimates proportion sites used relatively reliably chimpanzees mostly detected present videos filmed high resolution highest recall rate false alarm rate videos containing chimpanzee frontal face views certainly study first step transferring face detection software lab field application results promising indicate current limitation detecting chimpanzees camera trap footage due lack suitable face views easily overcome level field data collection combined placement multiple high resolution cameras facing reverse directions enable routinely conduct chimpanzee occupancy surveys based camera trapping semi automated processing footage
background lung transplant ltx recipients high risk invasive aspergillus infections iai however randomized controlled trials rct international guidelines antifungal prophylaxis afp ltx population exist methods meta analysis performed determine whether afp reduces rate iai ltx total six eligible observational studies five prophylaxis one targeted prophylaxis three studies including heart lung transplantation total patients included results pooled odds ratio iai ifi intervention arm control group confidence interval pooled studies characterized substantial heterogeneity number needed treat subgroup analyses exclusion heart transplant recipients also showed statistically significant reduction iai afp conclusion study suggests universal antifungal prophylaxes reduces incidence iai ltx however included studies limited small sample size single center structure without randomization mixed population including heart heart lung transplant heterogeneity due variations immunosuppression type duration afp therefore clear need adequately powered rct
patients philadelphia negative chronic myeloproliferative neoplasms mpns anti thrombotic cytoreductive treatment follow may affect evaluation pro thrombotic weight clinical biological characteristics diagnosis order avoid potential confounding effect investigated relationship prior thrombosis prth thrombosis occurred diagnosis treatment characteristics diagnosis thrombocythemic patients mpn reclassified according criteria prth occurred patients similar rates different mpns multivariate analysis prth rate significantly related minor thrombocytosis platelets higher hematocrit hct jak mutation older age cardiovascular risk factors cvrfs highest prth rate associated coexistence minor thrombocytosis leukocytosis note inverse relationship prth rate platelet count consistent hemostatic paradox thrombocytosis conclusion analysis mpn patients disclosed unbiased characteristics diagnosis pro thrombotic effect moreover suggests optimal control blood cells counts cvrfs might utmost importance prevention thrombosis follow elsevier ltd rights reserved
aim spinal trauma one important causes trauma related morbidity worldwide spinal injuries often caused traffic accidents falls sports injuries firearm injuries aim study stress incidence injury mechanism spinal traumas types spinal traumas province retrospectively reviewing patients material method patients applied emergency department neurosurgery clinic elazig education research hospital spinal trauma traffic accidents classified vehicle vehicle accidents falls classified according height follows falls heights height result patients admitted due falls height patients admitted due falls heightr patients admitted due vehicle traffic accidents patients admitted due vehicle traffic accidents patients admitted due sports injuries one patient admitted due assault thirty one patients underwent surgery due neurological deficit radiological instability fifty eight patients managed conservative approach one patient died pre operative period discussion aim study indicate incidence spinal trauma mechanism injury types spinal trauma province epidemiological study
investigated theory mind tom deficits alzheimer disease possible connection autobiographical memory abm patients matched controls evaluated compared using video based tom test autobiographical fluency task neuropsychological test battery found tom deficits positively associated semantic abm clinical group whereas positive relationship appeared tom episodic abm controls hypothesize reflects course disease well semantic abm used tom processing still accessible furthermore assume also less efficient turn leads specific deficit profile social cognition
paper conduct research communication technology complex talent training mode home abroad order adapt development modern science technology training adapt production construction management service first line need moral intellectual physical beauty aspects comprehensive development higher technology applied talents higher education must carry reform teaching methods teaching means reform traditional teaching method extensively absorb apply modern teaching means education teaching methods teaching means reform basis teaching reform cultivate students innovative spirit practice ability learning ability effective ways necessary guarantee improve teaching quality article combines advantages communication technology complex talent training mode home abroad propose novel paradigm enhance effectiveness current research condition
novel aupd bimetallic alloy nanoparticles nps decorated two dimensional bivo nanosheet photocatalysts successfully synthesized via mild wet chemical process facile deposition procedure composite photocatalysts characterized ray diffraction xrd scanning electron microscopy sem transmission electronic microscope tem ray photoelectron spectroscopy xps vis diffuse reflection spectroscopy drs electron spin resonance esr surface photovoltage spectroscopy spv aupd bivo nanosheets showed highest photocatalytic activity degradation rhodamine rhb visible light lamp coupled cutoff filter lambda photocatalytic efficiency improved times compared pure bivo bivo respectively novel aupd bivo composites may make way synthesize semiconductor composites potential applications solar energy conversion environmental purifications elsevier rights reserved
construction automated systems intended control electric power systems requires high speed mathematical tools research aimed developing algorithms construction automated systems control active components electrical network method applied authors describe object control based universal approach mathematical modeling nonlinear dynamic system black box type represented volterra polynomial degree paper presents new algorithm identification volterra polynomial second degree non stationary dynamic systems allow active experiment using test sets input signals makes possible input output characteristics object obtain adequate fast mathematical description results enable assess applicability mathematical apparatus control active components electric power system power quality parameters taken account objective vector
purpose study analyze swing characteristics kicking leg order elucidate technical mechanisms drive curve shot topspin curve shot orientation ankle joint point ball impact closely resembles orientation general curve shot inside shot moreover ankle joint movement point ball impact less mediolateral movement direction compared curve shot movement vertical direction direction based fact angle vertical rotational axis point larger shots likely one factors generating topspin ball therefore believe important fundamental characteristics drive curve shots smaller angle attack larger vertical movement ankle joint point impact compared normal curve shots authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
objectives measure strain fiber groups subscapularis muscle various glenohumeral joint positions determine appropriate shoulder position subscapularis muscle stretching design repeated measures design setting biomechanics laboratory specimens nine frozen thawed glenohumeral joints obtained fresh cadavers interventions applicable main outcome measure strain upper middle lower fiber groups subscapularis measured precise displacement sensors different glenohumeral joint positions results glenolmmeral joint position showed largest strain varied among fiber groups although position showed significantly large strain upper middle fiber groups external rotation degrees degrees degrees elevation abduction flexion horizontal abduction revealed significantly greater strain lower fiber groups additionally except external rotation degrees elevation strain lower fiber group significantly greater upper middle fiber groups external rotation conclusions stretching position fiber group subscapularis differs depending glenohumeral joint position external rotation degrees degrees glenohumeral elevation abduction flexion horizontal abduction significantly stretch lower fiber group subscapularis muscle
increasing demands functional temporal requirements software electric motor controllers demand solutions efficient time space usage providing required functionality embedded software electric motor control must deal control operation protection supervision safety user interfaces concerning need embedded software multitasking architecture combines concept function queues state based code proposed compared standard implementation based rtos proposed solution queue function pointers partitioned several shorter queues one active given state system thus reducing queue management overhead
research ethnicity focused visual cues however accents strong social cues match contradict visual cues examined understudied reactions people whose one cue suggests one ethnicity whereas cue contradicts experiment conducted germany job candidates spoke accent either congruent incongruent german turkish appearance based ethnolinguistic identity theory predicted accents would strong cues categorization evaluation based expectancy violations theory expected incongruent targets would evaluated extremely congruent targets predictions confirmed accents strongly influenced perceptions turkish looking german accented targets perceived competent targets additionally warm findings show bringing together visual auditory information yields complete picture processes underlying impression formation
sorting related receptor type repeats sorla intracellular sorting receptor directs cargo proteins kinases phosphatases signaling receptors correct location within cell activity sorla assures proper function cells tissues receptor dysfunction underlying cause common human malignancies including alzheimer disease atherosclerosis obesity discuss molecular mechanisms govern sorting sorla cargo multiple cell types genetic defects receptor results devastating diseases
traditional chinese medicine encompasses many different practices notably acupuncture moxibustion traditionally modalities used combination augment treatment seldom tested together clinical studies numerous acupuncture studies conducted asia europe united states randomized controlled trials utilizing moxibustion outside east asia limited studies described use moxibustion control placebo procedure methods developing acupuncture moxibustion protocol used randomized controlled trial irritable bowel syndrome diarrhea predominant adults described approach conformed scientific rigor clinical trial consistent foundations traditional chinese medicine
light profound effects mood regulation exemplified seasonal affective disorder sad therapeutic benefits light therapy however underlying neural pathways light regulates mood well understood previous work developed diurnal grass rat arvican niloticus animal model sad following housing conditions either dim light dark dld short photoperiod mimic lower light intensity short day length winter respectively grass rats exhibit increase depression like behavior compared housed bright light dark bld condition furthermore shown orexinergic system involved mediating effects light mood anxiety explore potential neural substrates involved depressive phenotype present study examined hypothalamic dopaminergic somatostatin sst neurons brains grass rats housed dld bld using immunostaining tyrosine hydroxylase sst found number sst cells hypothalamus significantly lower dld groups compared bld group also found treating bld animals selective orexin receptor oxr antagonist significantly reduced number hypothalamic cells present study suggests hypothalamic neurons sensitive daytime light deficiency regulated orexinergic pathway results support hypothesis orexinergic pathways mediate effects light neuronal systems collectively contribute light dependent changes affective state elsevier ireland ltd rights reserved
persistent deficits social behavior motor behavior behavioral flexibility among major negative consequences associated exposure ethanol prenatal development prior work laboratory linked moderate prenatal alcohol exposure pae rat deficits behavioral domains depend upon ventrolateral frontal cortex hamilton manipulations social environment cause modifications dendritic morphology experience dependent immediate early gene expression ventrolateral frontal cortex hamilton may yield positive behavioral outcomes following pae present study evaluated effects housing pae rats non exposed control rats adult behavior rats sexes either paired partner prenatal treatment condition ethanol saccharin opposite condition mixed housing condition four months age similar months housing manipulation commenced social behavior tongue protrusion behavioral flexibility morris water task measured hamilton behavioral effects moderate pae primarily limited males ameliorated housing non ethanol exposed partner unexpectedly social behavior motor behavior spatial flexibility adversely affected control rats housed pae rat mixed housing indicating housing pae rat broad behavioral consequences beyond social domain observations provide evidence moderate pae negatively affects social behavior underscore importance considering potential negative effects housing pae animals behavior critical comparison groups elsevier rights reserved
brazilian institutions involved polymer education grown substantially last decades number quality paper provides panorama current situation presenting view brazilian educational system discussing polymer education evolved country fits within structure given continental dimensions brazil regional analysis presented examining aspects polymer teaching undergraduate postgraduate levels presence specific courses polymer science syllabi chemistry chemical engineering materials engineering programs delivered brazilian institutions considered importance funding agencies sponsoring polymer education research postgraduate level crucial role brazilian polymer associtation abpol promoting aspects polymer education brazil highlighted
ethnopharmacological relevance kai xin san kxs traditional formula chinese medicine used treat dementia aim study present study aimed investigate ameliorating effects beta induced cognitive impairment rats using series novel reward directed instrumental learning tasks determine possible mechanism action materials methods rats pretreated kxs aqueous extract days trained gain reward reinforcement lever pressing meantime thereafter rats received bilateral microinjection beta cal regions hippocampus cognitive performance evaluated goal directed higher response ratio habit visual signal discrimination extinction learning tasks well levels memory related biochemical parameters molecules results findings first demonstrated kxs improve beta induced amnesia rdil via enhancing comprehension action outcome association utilization cue information guide behavior ameliorating effects attributed modulation memory related molecules hippocampus conclusion conclusion icxs potential prevent delay deterioration cognitive impairment
many university level electrical engineering courses continue use textbooks curriculum scaffolds prescribed texts reference volumes textbook reliance even pronounced courses teach foundational principles discipline introductory circuit theory paper reports conceptual coverage introductory electric circuit theory presented textbooks specifically comparative study six texts performed using analytic framework based prior research conceptual understanding organized around multiple criteria ideas conceptual framework conceptual links used identify potential conceptual gaps textbook analysis reveals majority books missing many important conceptual features findings study beneficial authors develop new editions books instructors evaluate select texts use courses study also inform ongoing efforts develop effective instructional materials investigate textbooks affect conceptual understanding
paper describes experimental investigation load settlement behaviour model strip footing resting reinforced homogeneous sand bed several embedment depths medium dense dense states sand reinforcement single layer woven geotextile layer without wraparound ends depth base footing width particular focus study effect wraparound ends reinforcement load bearing capacity experimental results study compared numerical findings finite element analysis carried using plaxis software study shows significant improvement load bearing capacity stiffness sand bed increasing footing embedment depth well provision wraparound ends reinforcement numerical results follow experimental results closely lower settlement values results presented graphical form paper used general guidelines practical conditions similar considered present study
background dietary energy density energy available relation gram intake inform disease risk objective objective study investigate association baseline dietary energy density risk incident type diabetes postmenopausal women design dietary energy density weight status type diabetes incidence prospectively characterized large cohort postmenopausal women participating one clinical trials observational study participants setting study involved postmenopausal women recruited women health initiative observational study clinical trials centers across united states main outcome measures primary outcome incident type diabetes statistical analyses performed association dietary energy density quintiles incident diabetes tested using cox proportional hazards regression results total participants without self reported diabetes enrollment completed baseline dietary assessment followed years risk diabetes developing greater women highest dietary energy density quintile compared lowest adjusting confounders body mass index calculated waist circumference mediated relationship dietary energy density diabetes waist circumference stratified analysis women dietary energy density quintiles waist circumferences greater risk diabetes developing compared women waist circumference conclusions prospective study higher baseline dietary energy density associated higher incidence type diabetes among postmenopausal women overall women elevated waist circumference
sorting related receptor gene sorl defined interesting candidate gene alzheimer disease recently one novel variant within sorl reported related late onset alzheimer disease load caucasians korean japanese aim case control study investigate whether sorl contributes susceptibility load chinese furthermore data along previously studies pooled determining risk polymorphism load polymorphism genotyped independent subjects northern han chinese population including cases age gender matched controls result case control study showed association polymorphism risk load northern han chinese population recessive model odds ratio confidence interval additive model results meta analysis subgroups caucasian asian whole showed minor allele allele within played protective effect risk respectively conclusion allele sorl may protective factor load caucasian han chinese
paper presents convergence analysis seidel method solving power systems automatic tasks condition use programmable logical controllers low capacity hardware algorithm solution based seidel method advantages memory saving however limits seidel method convergence electrical network condition close resonance assurance seidel method converge result made experiments conclude usage relaxation method conjunction convergence control phase plane allows solve network analysis problem nonexpansible hardware
paper concerned design self scheduled current controller doubly fed induction machines design based framework linear parameter varying systems mechanical angular speed considered measurable time varying parameter objective obtain robust dynamic performance variations mechanical rotor speed specified operating range employing benefits digital control continuous discrete time transformation utilized replace continuous time current controller approximating discrete time controller experimental results provided demonstrate performance robustness controlled system respect changes mechanical rotor speed stator voltage dips
purpose study assess effectiveness yoga based social emotional wellness promotion program transformative life skills tls indicators adolescent emotional distress prosocial behavior school functioning participants included students attending inner city school district randomly assigned treatment business usual comparison conditions results suggested students participated tls program demonstrated significant reductions unexcused absences detentions increases school engagement significant concurrent improvements primary engagement stress coping strategies secondary engagement stress coping strategies noted well specifically significant increases student emotion regulation positive thinking cognitive restructuring response stress found effects found measures somatization suspensions academic grades general affect student report treatment acceptability indicated intervention generally well received strategies perceived socially valid participants implications directions future research discussed
objective evaluate socio economic demographic determinants anemia among indian children aged months methods statistical analysis performed cross sectional weighted sample children national family health survey using multinomial logistic regression assess significance risk factors different degrees child anemia anemia diagnosed world health organization cut points hemoglobin level pearson chi squared test applied justify associations anemia different categories study population results prevalence anemia mild moderate severe anemia overall prevalence rate along mild moderate cases showed increasing trend years age decreased rural children higher prevalence rate indian states study states showed high prevalence highest bihar higher birth order high index poverty low level maternal education mother anemia non intake iron supplements pregnancy vegetarian mother increased risks types anemia among children christian population lower risk scheduled caste scheduled tribe backward class categories higher risk anemia conclusion results suggest need proper planning implementation preventive measures combat child anemia economically privileged groups maternal nutrition education birth control measures priorities programs sociedade brasileira pediatria published elsevier editora ltda rights reserved
digital predictive peak current control ppcc employing adaptive slope compensation proposed paper ppcc precisely predicts peak current reference adaptive slope compensation according operation regions load conditions thereby ppcc control peak inductor current significantly reduces total harmonic distortion compared conventional digital average current control duty ratio feed forward widely used addition parts ppcc implemented utilizing internal high resolution ramp generator comparator digital signal processor without external components principle analysis ppcc presented performance feasibility verified experimental results universal input rms similar rms output laboratory prototype
safety remains major challenge construction industry throughout world yet longitudinal quasi longitudinal studies domain paper demonstrates quasi longitudinal study provide insight safety performance comparison made two cross sectional studies questionnaires collected construction workers collected ontario canada data comprised demographic factors safety climate factors three safety outcome categories rates injury stress safety events reduced overall since although change significant events findings show improved consistency safety awareness among participants independent employers suggesting regionwide safety programs effective safety climate factors accounted variance safety outcomes interpersonal conflict work strongly related safety outcome types participants years experience reported highest safety incident rates categories trend observed years earlier safety managers may consider broadening safety programs often target new workers ensure workers reminded safe work practices american society civil engineers
aims objective study examine effect eriodictyol melanogenesis cultured murine melanoma cells antigenotoxic antioxidant potentials primary human keratinocyte phk cells main methods anti melanogenic effect performed via determination melanin content tyrosinase activity antigenotoxicity antioxidant potentials assessed comet cellular antioxidant assays respectively key findings eriodictyol reduced melanogenesis inhibiting tyrosinase activity cells dose dependant manner eventual genotoxicity investigated evaluating capacity induce dna degradation treated cell nuclei genotoxicity detected different tested concentrations ability protect cell dna hydrogen peroxide oxidative effect phk cells investigated using comet assay appears eriodictyol solution suppressed induced genotoxicity addition molecule revealed significant cellular antioxidant capacity reactive oxygen species formation phk cells significance thus eriodictyol could introduced natural skin depigmenting agent skin care products elsevier inc rights reserved
objective determine exercise adherence interventions effective achieving ongoing exercise adherence adults chronic health conditions already completed supervised short term program method search medline ovid medline april embase april cinahl april cochrane central register controlled trials conducted chronic health conditions search terms per chronic disease participation work aihw report included randomised quasi randomised trials observational studies evaluating interventions aimed improve exercise adherence adults chronic health conditions completed supervised exercise program random effects meta analyses random effects logistic meta regression used examine relationships exercise adherence strategy adherence results eleven studies included total participants chronic obstructive pulmonary disease diabetes cardiovascular disease osteoarthritis methods used maintaining adherence categorized post hoc centre based programs home exercise programs telephone follow home exercise programs follow weaning programs transitioned patients independent site exercise program difference proportion participants fully adherent exercise program months centre based follow pooled proportion fully adherent telephone follow pooled proportion fully adherent difference value conclusion interventions centre based exercise programs home exercise programs without telephone follow differentially impact exercise adherence people completed short term supervised program
various intelligent fleet disposition algorithms used allocate mobility requests fleet electric vehicles however none incorporate issue site energy generation company running mixed fleets work presents approach distribute trips mixed fleet conventional internal combustion engine vehicles battery electric vehicles coordination decentralized energy management economic ecologic target parameters maximized includes detailed charging schedule new algorithm based mixed integer linear program developed incorporates variable charging infrastructures mobility profile company different vehicle classes produce optimized usage schedule company main findings new developed model capable analyzing financial ecological potential substituting individual icevs bevs provides customized recommendation optimal fleet composition depending number trips specification vehicles authors published elsevier
network security situation awareness vital important network security supervision order obtain network security situation effectively multidimensional assessment method proposed paper method composed three dimensions different levels namely vulnerability threat basic operation quantitative calculation method index service layer cvss standard adopted assess vulnerability situation simplified dread model chosen threat situation node layer vulnerability situation service layer added weight threat situation service layer accumulated according attack paths based markov model basic operation situation evaluated evidence fusion several host network performance index network layer situation equals weighted summation corresponding situation node layer experimental results show ease use method multi dimensional situation depicts overall safety evolution process network system accurately intuitively
background much research address practical needs stakeholders responsible introducing health care delivery interventions organizations working achieve better outcomes article present approach using consolidated framework implementation research cfir guide systematic research supports rapid cycle evaluation implementation health care delivery interventions produces actionable evaluation findings intended improve implementation timely manner methods present approach describe formative cross case qualitative investigation primary care practices participating comprehensive primary care cpc initiative multi payer supported primary care practice transformation intervention led centers medicare medicaid services qualitative data include observational field notes semi structured interviews primary care practice leadership clinicians administrative medical support staff use intervention specific codes cfir constructs reduce organize data support cross case analysis patterns barriers facilitators relating different cpc components results using cfir guide data collection coding analysis reporting findings supported systematic comprehensive timely understanding barriers facilitators practice transformation approach using cfir produced actionable findings improving implementation effectiveness initiative identifying improvements implementation strategies future practice transformation efforts conclusions cfir useful tool guiding rapid cycle evaluation implementation practice transformation initiatives using approach described systematically identified adjustments refinements intervention could made second year year intervention think approach describe broad application encourage others use cfir along intervention specific codes guide efficient rigorous analysis rich qualitative data
area around ragusa sicily well known exploration petroleum deposits hosted mesozoic carbonate rocks reservoirs overlain less permeable rocks whereas surface geology characterized outcrops oligo miocene carbonate units hosting important aquifers karst springs area used drinking water supplies therefore vulnerable aquifers monitored protected adequately early afternoon may late evening may construction exploitation borehole tresauro drilling fluids lost unknown karst void two days later may water flowing paradiso spring lying borehole lower normally used domestic water supply intensely coloured unfit drinking bulk chemical analyses carried water shown composition similar drilling fluids lost tresauro borehole confirming hydrological connection estimations indicate first signs drilling fluids took flow injection point spring corresponding mean velocity similar paradiso spring recharged well developed underground drainage system also confirmed marked flow rate changes measured spring ranging base flow around flood peaks reflecting source nature initial contamination pollution lasted days water returned acceptable drinking water standards relatively quickly however pollution related heavy mineral fines continues registered flooding spring aqueducts normally shut high turbidity values pollution event offers instructive example hydrocarbon exploitation intensely karstified areas natural springs provide domestic water supplies controlled effectively prevent disasters occurring pollution incident also useful example accidental tracer tests identify rapid karstic flow paths long distances elsevier rights reserved
scholars increasingly interested everyday interactions various places people different ethnic religious background impact inter group relations drawing representative surveys leeds warsaw examine whether encounters ethnic religious minorities different type space associated tolerance towards find leeds favourable affective attitudes associated contact institutional spaces workplace study places socialisation spaces social clubs voluntary groups religious meeting places however case behavioural intentions operationalised willingness friendly minority neighbours encounters socialisation spaces play significant role prejudice reduction warsaw people contacts ethnic religious minorities public streets park public services transport consumption spaces cafes pubs restaurants express positive affective attitudes towards encounters consumption space translate willingness friendly minority neighbours authors published elsevier inc
proposed replacing regular electric motor output shaft seals magnetic fluid seals ensure leak tightness upper bearing assemblies mathematical model takes account interaction magnetic hydrodynamic processes seal gap developed results tests operation magnetic fluid seals reported
background multiple sclerosis patients faced complex risk benefit profiles disease modifying drugs dmds making treatment decisions effective shared decision making patients understand risks benefits dmds make treatment decisions based personal preferences methods inclusive systematic review primarily assess current understanding patients information dmds provided standard healthcare system secondary aim assesses patients preferences specific risks benefits treatments systematic search conducted using pubmed embase google scholar total studies reviewed across aims relevant quantitative qualitative data extracted two authors narrative synthesis conducted due heterogeneity research findings results trend dmd risks generally underestimated dmd benefits generally overestimated patients treatments could potentially offer substantial symptom improvement delay disease progression reduction relapses preferred even expense higher risks conclusions many patients experience information standard healthcare system provide satisfactory understanding risks benefits dmds effective ways communicate risk benefit dmd information making shared treatment decisions needs identified patient preferences dmd risks benefits also taken account elsevier rights reserved
exact function human gasdermin gsdmb regulates differentiation growth epithelial cells yet elucidated human epidermal growth factor receptor positive breast cancer gsdmb gene amplification protein overexpression indicate poor response targeted therapy genome wide association studies revealed correlation gsdmb snps increased susceptibility crohn disease ulcerative colitis asthma terminal domains gasdermins possess lipid binding regulatory activities respectively inflammatory caspases cleave gasdermin interdomain linker gsdmb cleaved terminal domain binds phosphoinositides cardiolipin forms membrane disrupting pores executes pyroptosis show full length gsdmb terminal domain bind nitrocellulose membranes immobilized phosphoinositides sulfatide cardiolipin addition gsdmb terminal domain binds liposomes containing sulfatide crystal structure gsdmb terminal domain reveals structural impact amino acids encoded snps linked asthma inflammatory bowel disease ibd loop carries polymorphism amino acids corresponding healthy individuals gly pro exhibits high conformational flexibility whereas loop carrying amino acids found individuals increased disease risk arg ser exhibits well defined conformation higher positive surface charge apoptotic executioner caspase inflammatory caspases cleave gsdmb dnvd within terminal domain selective sulfatide binding may indicate possible function gsdmb cellular sulfatide transport
training image based geostatistical methods increasingly popular groundwater hydrology even existing algorithms present limitations often make real world applications difficult limitations include computational cost prohibitive high resolution applications presence visual artifacts model realizations low variability model realizations due limited pool patterns available finite size training image paper address issues proposing iterative patch based algorithm adapts graph cuts methodology widely used computer graphics adapted graph cuts method optimally cuts patches pixel values borrowed training image assembles successively time accounting information previously stitched patches initial simulation result might display artifacts identified regions high cost artifacts reduced iteratively placing new patches high cost regions contrast patch based algorithms proposed scheme also efficiently address point conditioning advantage method cut process results creation new patterns present training image thereby increasing pattern variability quantify effect new measure variability developed merging index quantifies pattern variability realizations respect training image series sensitivity analyses demonstrates stability proposed graph cuts approach produces satisfying simulations wide range parameters values applications cases compared state art multiple point methods results show proposed approach obtains significant speedups increases variability realizations connectivity functions applied models transport simulations models used demonstrate pattern continuity preserved
background aim auriculotemporal nerve atn one branches mandibular division trigeminal nerve gives rise many branches retromandibular temporal regions superficial temporal branch occasionally cause migraine headaches auriculotemporal neuralgia purpose study elucidate anatomy superficial temporal branch never described detail methods total sides cadaveric heads used study number superficial temporal branch counted horizontal vertical distances middle tragus branching point measured results three sides two main trunks sides one main trunk duplicated atn already branches two main trunks left retromandibular space number superficial temporal branches ranged two seven vertical horizontal distances middle tragus branching point superficial temporal branch ranged respectively communicating branches occasionally formed loop called ansa double ansa identified one case conclusions data provide surgeons better view course distant branches skin incisions better planned british association plastic reconstructive aesthetic surgeons published elsevier ltd rights reserved
last fifty years mechanical properties ceramic materials greatly improved toughness strength increased scatter strength decreased adequate statistical design procedures brittle materials exist cracking brittle fracture ceramic components still occur often review theory brittle fracture underlying assumptions critically discussed measurement procedures strength reviewed shown strength materials strength specimens strength components often quite different properties three main factors identified order avoid unexpected failure components considered much past hidden stresses stresses caused thermal strain mismatch contact example joints internal stresses quality component surfaces edges iii proper handling ceramic materials components clearly stated mechanical properties many ceramic materials appropriate even applications severe loading conditions bad incomplete mechanical design insufficient surface finish mishandling main reasons unexpected failure ceramic components elsevier ltd rights reserved
paper presents high speed drive used electrically assisted turbo charging internal combustion engine electrification turbo charger system enhance performance reduce dynamic drawbacks affect conventional solutions turbo lag however design electric drive presents challenges especially related thermally aggressive environment high rotational speed therefore system level design approach needs adopted different sub systems drive addressed simultaneously thus paper includes considerations thermal electromagnetic machine design furthermore voltage source inverter featuring wide bandgap sic power devices described sensorless rotor position detection digital control used drive machine finally test setup preliminary experimental results presented
aim aim current study collect clinical normative data clinical impairment assessment questionnaire cia eating disorder examination questionnaire ede adult patients eating disorders eds study also examined unique contributions eating disorder symptoms levels related impairment methods sample patients females males recruited six specialist centres across norway majority sample diagnosed eating disorder otherwise specified ednos bulimia nervosa diagnosed anorexia nervosa results significant differences global ede cia scores females males female sample significant differences found several ede sub scales group ednos group significant differences found diagnostic groups cia male sample significant differences found diagnostic groups ede cia multiple regression analysis revealed variance impairment measured cia accounted symptoms conclusions body mass index eating concern shape weight concern binge eating served significant unique predictors impairment results present study contribute interpretation ede cia scores samples
attempting educate practitioners computer security difficult reason breadth knowledge required today security profession includes widely diverse subfields including cryptography network architectures programming programming languages design coding practices software testing pattern recognition economic analysis even human psychology individual may choose specialize one narrow elements pressing need practitioners solid understanding unifying principles whole created playground network simulation tool used instruction network security course graduate students tool created three specific purposes first provides simulation sufficiently powerful permit rigorous study desired principles simultaneously reducing eliminating unnecessary distracting complexities second permitted students rapidly prototype suite security protocols mechanisms finally equal rapidity students able develop attacks protocols created based observations student reviews believe three features combine create powerful pedagogical tool provides students significant amount breadth intense emotional connection computer security single semester
one variations frequent pattern mining erasable pattern mining discovers patterns benefits lower equal user specified threshold product database although traditional erasable pattern mining algorithms perform mining operations static mining environments suitable dealing dynamic data stream environments dynamic data streams algorithms process immediately one database scan order consider characteristics data stream mining however previous tree based erasable pattern mining methods difficulty processing dynamic data streams need two database scans construct tree structures addition also consider specific information item within product database need conduct mining operations considering additional information items order find useful erasable pattern results reason paper propose weighted erasable pattern mining algorithm suitable sliding window based data stream environments algorithm employs tree list data structures efficient mining processes solves problems previous erasable pattern mining approaches using sliding window based stream processing technique item weight based pattern pruning method compare performance proposed algorithm state art tree based approaches respect various real synthetic datasets experimental results show method efficient scalable competitors terms runtime memory pattern generation elsevier rights reserved
simulation hydratlic behaviour water distribution networks wdn needs develop implement mathematical model able consider wide range control devices complex systems literature overview primarily provided solution procedures steady state simulation nonlinear pipe network hydraulics typical elements pressure regulating valves conceptually described differentiated functional characteristics incorporate hydraulics simulation model explored considering possible topological positions operating states novel efficient methodology using unknown head loss function initially presented hydraulic simulation network flow problems containing static dynamic closed pipes closed pipes mainly obtained distribution networks either turning isolation valves pipe segment result operating state unidirectional control devices depending pressure distribution pipe network thereupon approach extended integrate control elements pipe networks check valves pressure reducing prv safety valves well booster pumping stations iterative numerical algorithm applied solve loop equations using newton raphson method linearised energy equation hardy cross technique locally used correct flow rates loops containing closed pipes iteration procedure developed hybrid approach demonstrated robust fast converging behaviour real world pipe network applications moreover consider variety combinations control devices different network configurations several empirical head loss formulas additionally used combination commonly known equations hazen williams colebrook white head loss formulas application algorithm briefly demonstrated discussing simulation results example real world large scale wdn
order dependencies ods describe relationship order lists attributes relational table ods help understand semantics datasets applications producing applications field query optimization suggesting query rewrites also existence table provide hints integrity constraints valid domain data hand work first describe discovery problem order dependencies principled manner characterizing search space developing proving pruning rules presenting algorithm order finds order dependencies given table order traverses lattice permutations attributes level wise bottom manner comprehensive evaluation show efficient even various large datasets
current scour estimation methods typically predict scour resulting uneconomical design tendency partly due complexity scouring process indicates aspects still well understood also attributed scale effects experiments conducted isolate influence relative coarseness flow shallowness scour depth range present study equilibrium scour depth decreases increasing limiting value approximate furthermore found depend scour influencing parameters held constant revised definition densimetric froude number using velocity along separating streamline shown influential role scour improved scour estimation method employing parameters presented compared current methods
background almost years ago senior united kingdom nurses met heathrow airport discuss challenges opportunities facing nursing one aspect heathrow debate encourage nurses work closer members public resulting report stated nurses effective working outside professional area particular adept working partnership public aim aim paper report study obtain views general practitioners gps community nurses members public public perceive community nursing aim explore perceptions senior health care managers policymakers public involvement primary care methods two stage delphi investigation undertaken community nurses gps members public addition one one interviews carried senior health service managers policymakers findings agreement following issues community nurses must work closely members public lack public understanding roles community nurses specialist nurses public support nurse prescribing preference seeing community nurse opposed people prefer one nurse care rather variety nurses comments managers senior policymakers showed agreement public involved primary care acknowledgement problematic number recommendations outlined
paper conduct research general computer graphics psychology applications animation design digital media art basis digital technology modern communication technologies human rational thinking perceptual thinking art new art form digital media art charm art means application technology performance field digital media art art design vitality development potential success field new media film television animation design extension first choose appropriate way correlation different ways connection determines final product development scale basic content design direction process design also pay special attention new media products relationship original animation use characteristics new media devices create new forms art summary method novel related areas
background extensile open approaches reduce fix intra articular calcaneal fractures associated high levels wound complications avoid complications technique percutaneous reduction fixation screws alone developed study assessed clinical outcomes radiographs postoperative scans operative treatment technique methods consecutive patients intra articular calcaneal fractures reviewed patients assessed early postoperative complications months injury clinical results assessed patients seen minimum year surgery mean follow years patients feet patients preoperative postoperative scans patients feet articular reduction quantitatively analyzed results month follow superficial infections rate screw irritation complications minimum year injury included screw irritation subtalar osteoarthritis requiring subtalar fusion malunion deep infection bohler angle calcaneal facet height width significantly improved postoperatively bohler angle increased average degrees postoperatively loss angle degrees month follow significant improvement posterior talocalcaneal joint reduction postoperative scan residual displacement remained final follow patients reported residual pain level lower conclusion study suggests reasonable early results could achieved percutaneous treatment intra articular calcaneal fractures using screws alone based articular reduction level residual pain level evidence level retrospective case series
aim study explore differences boys girls diagnosis clinical phenotypes autism spectrum disorder asd china mainland children diagnosed asd females retrospectively included analysis children assessed using autism diagnostic interview revised adi autism diagnostic observation schedule ados results showed girls scored significantly higher adi socio emotional reciprocity boys also scored lower adi ados restricted repetitive behaviors rrbs meanwhile proportions girls satisfied diagnostic cut scores adi rrbs domain lower boys results indicated girls asd show greater socio emotional reciprocity boys girls also tended show fewer rrbs boys type rrbs girls differ boys adi found less sensitive girls particularly assessment rrbs domain
substantial increases energy consumption second half last century amplified use fossil fuels various economic sectors mainly power sector also low efficient technologies still adopted many countries mounted losses associated various energy conversion processes substantial levels tasks challenges associated transferring power sectors energy wasting utilities advanced smart grid based utilities discussed article transfer lebanese dilapidated aging electrical power sector modern economically profitable sector adopted two major projects adopted lebanese electrical network control center advanced metering infrastructure article explains outcomes impacts major components two projects article also discusses problems encountered implementation process lebanese electrical network control center several original software packages modified research team properly integrate lebanese electrical network control center aging lebanese power sector finally article describes controlled design project also implemented part lebanese electrical network control center project highlights problems associated upgrading high voltage transmission lines
models crucial engineering design process used optimisation design parameters prediction performance thus models significantly reduce design development optimisation costs paper presents construction process novel equivalent electrical model darrieus type vertical axis wind turbines dtvawts physical concepts theoretical formulations underpinning development model addressed proposed model built mechanical description given paraschivoiu double multiple streamtube model based analogy mechanical electrical circuits highlighting working principle dtvawt step step development model presented assessment purposes simulations aerodynamic characteristics corresponding electrical components performed compared
paper proposes design procedure satisfy steady state stable transient characteristics closed loop poles controller strongly stable generalized predictive control gpc systems strongly stable control system defined system stable poles closed loop systems stable poles controllers strong stability important safety system stable even feedback loop get breakdown accident authors already derived strongly stable controller gpc systems designing strongly stable gpc three characteristics specified poles closed loop system poles controller steady state gain existing strong stable gpc authors extended standard gpc two degree freedom compensators using coprime factorization approach introducing new design parameters extended gpc exist hidden poles brought pole zero cancellation initial condition mismatch sudden change state impulsive disturbances effect hidden poles appears means safety poles including hidden poles stable design safe gpc requires satisfy three characteristics needs complicated trade design parameters paper proposes calculate mathematical expressions using symbolic computation software make trade simple example water level control plant mathematical expressions obtained explicitly using expressions controller designed satisfy three specifications
attention biases sleep related stimuli held play key role development maintenance insomnia biases shown controlled visual displays study investigated whether observers insomnia symptoms allocate attention sleep related items natural scenes recording eye movements free viewing bedrooms participants insomnia symptoms normal sleepers matched visual exploration scenes evidence attention insomnia symptoms captured quickly sleep related stimuli normal sleepers however insomnia group fixated bed regions trials fixated bed also remained longer findings indicate sleep stimuli particularly effective retaining visual attention complex natural scenes elsevier ltd rights reserved
recent research demonstrated participants prefer complete larger series responses exchange longer duration reinforcer access rather completing fewer tasks associated smaller frequent reinforcer access review provides summary line research examines variables contributing participant preference performance different response reinforcer arrangements discusses limitations areas future research
background laparoscopic sleeve gastrectomy lsg restrictive bariatric surgery procedure currently second performed technique worldwide follow data depression stress eating behaviour scarce aim longitudinal study investigate medium term effects lsg mental health eating behaviour influence weight loss using comprehensive interview based assessment methods seventy five individuals undergone lsg university hospital included study symptoms disordered eating assessed using structured clinical interview eating disorder examination three factor eating questionnaire depressive symptoms stress assessed via patient health questionnaire results mean interval lsg follow examination months total body weight loss depressive symptom scores improved pre operative iqr iqr stress scores patients reported loss control eating grazing paralleled increased body mass index stress depressive symptoms prior lsg nine patients fulfilled diagnostic criteria binge eating disorder one conclusions post surgical mental health appears highly relevant terms weight loss maintenance likely surgical outcome could positively influenced patients risk developing mental health issues eating disorders identified monitored order offer targeted interventions
optimal control problems linear nonlinear ordinary differential equations related optimal switching different magnetic fields considered main aim move electrical initial current controllable voltage shortest time desired terminal current hold afterwards necessary optimality conditions derived pontryagin principle formal lagrange technique case linear system principal structure time optimal controls discussed associated optimality systems solved one shot strategy using multigrid software package various numerical examples discussed copyright john wiley sons ltd
ingredients betel chew usually kept special box bowl used exclusively betel chewing tepak sirih reflects life value malay community especially traditional customs codes conduct obvious tepak sirih plays important role everyday life malays however time passes importance tepak sirih confined ceremonial traditional events activities decorated embroidered tepak sirih used ceremonies visit observe adat merisik proposal adat meminang engagement adat bertunang study identifies examines role tepak sirih nonverbal communication marriage customs malay community study conducted kampung seri kedah sungai leman sekinchan selangor finding shown tepak sirih used malay wedding seen symbol opening conversation symbol asking symbol accepting symbol rejecting symbol unity tepak sirih placed front items used wedding malay wedding tepak sirih bertekad made wood embroidered used interior tepak sirih holds small globular covered boxes cembul little cylindrical container sliced areca nut lime gambier cloves cembul must placed according malay customs furthermore malay community believe something bad may occur customs followed addition arranging cembul tepak seen sign educate malay community importance following rules engagement adat bertunang tepak sirih plays seen symbol acceptace live together also promises engagement tie promise man woman get married akad nikah
background prolongation peak end interval wave reported associated ventricular arrhythmias aim study investigate ventricular repolarization using interval ratio qtc ratio patients subclinical hypothyroidism methods studied volunteers patients mean age years healthy subjects mean age years basic biochemical parameters analyzed electrocardiograms ecgs recorded intervals qtc intervals qtc ratios calculated categorical numerical variables compared using chi square test independent test respectively correlations analyzed using spearman pearson correlation tests results found difference qtc intervals groups subjects intervals ratio qtc ratio increased compared healthy subjects also found positive correlations levels thyroid stimulating hormone tsh ratio qtc ratio subjects left ventricular myocardial performance index mpi increased compared healthy subjects although significant conclusions compared healthy subjects patients demonstrated longer intervals higher qtc ratios tsh levels positively correlated interval ratio qtc ratio
sparse wireless sensor network forest fire detection considered assumed two types malicious nodes exist network malicious behaviors assumed concealed statistical behavior lightweight centralized trust based model proposed detect malicious misbehaving nodes assume nodes contribute process gathering statistical data related communication neighbors data periodically sent base station trust functions executed simulation model built evaluate system performance results show proposed model efficient detecting types considered malicious nodes
order take full advantage distributed generators evolution classical power system organization management also necessary aggregator residential urban electrical network considered distribution system operator stakeholder able control cluster local generators loads technical constraints connection remaining distribution grid commercial contracts outer electrical producers paper focused design microgrid central energy management system relies day ahead operational planning online adjustment procedure operation dynamic programming based algorithm derived solve unit commitment problem multiobjective function order reduce economic cost equivalent emissions proposed energy management system implemented supervisory control data acquisition scada tested using hardware loop simulation urban network economic environmental gains evaluated
revisit shift technique applied quasi birth death qbd processes functional form bringing attention existence properties canonical factorizations regard prove new results concerning solutions quadratic matrix equations associated qbd results find applications solution poisson equation qbds imacs published elsevier rights reserved
background establishment consistent bedtime routine activities occur right lights often recommended part healthy sleep habits however studies investigated dose dependent association bedtime routine sleep outcomes especially young children particularly recommended thus aim study examine associations consistent bedtime routine sleep outcomes young children ages large global sample assess whether dose dependent relationship frequency bedtime routine concurrently retrospectively sleep outcomes participants mothers children australia new zealand canada china hong kong india japan korea malaysia philippines singapore thailand united kingdom united states completed brief infant child sleep questionnaire results consistent bedtime routine associated better sleep outcomes including earlier bedtimes shorter sleep onset latency reduced night wakings increased sleep duration decreased parent perceived sleep problems daytime behavior problems also related institution regular bedtime routine furthermore dose dependent relationship better outcomes associated increased doses bedtime routine currently retrospectively found within predominantly asian predominantly caucasian cultural regions conclusions results indicate regular nightly bedtime routine associated improved sleep young children suggests consistently bedtime routine instituted younger started better
present paper schiffs approximation applied study light scattering large optically soft axisymmetric particles special attention cylindrical spheroidal photosynthetic micro organisms approximation similar anomalous diffraction approximation includes description phase functions resulting formulations radiative properties multidimensional integrals numerical resolution requires close attention argued strong benefits expected statistical resolution monte carlo method designing efficient monte carlo algorithms requires development non standard algorithmic tridcs using careful mathematical analysis integral formulations codes develop make available include original treatment nonlinearity differential scattering cross section squared modulus scattering amplitude thanks double sampling procedure approach makes possible take advantage recent methodological advances field monte carlo methods illustrated estimation sensitivities parameters comparison reference solutions provided matrix method presented whenever possible required geometric calculations closely similar used standard monte carlo codes geometric optics computer graphics community calculation intersections rays surfaces opens interesting perspectives treatment particles complex shapes elsevier ltd rights reserved
linear hashing efficient widely used version extendible hashing distributed version stores key value pairs hundreds thousands sites distributed system implements dictionary data structure efficiently using central component allows key based operations insertion deletion actualization retrieval well scan operation use central addressing component clients servers commit addressing error sending request wrong server server forwards message correct server either directly one never one additional forward operation discuss methods avoid double forward rare still might breach quality service guarantees compare methods pushes information changes file structure clients whether active second problem especially relevant high churn environments modern data centers sites suddenly become inaccessible various high scalable reliability versions reconstruct data lost site elsewhere present solution resulting wandering bucket problem allows clients find data new location
water footprint developed within water resources research community volumetric measure freshwater appropriation concept used assess water use along supply chains sustainability water use within river basins efficiency water use equitability water allocation dependency water supply chain purpose integrating life cycle assessment products lca scholars proposed weight original volumetric water scarcity catchment located thus obtaining water scarcity weighted reflects potential local environmental impact water consumption paper provides elaborate critique proposal main points counting litres water use differently based level local water scarcity obscures actual debate water scarcity allocating water resources competing uses depletion global scale neglect green water consumption ignores fact green water scarce well since water scarcity catchment increases growing overall water consumption catchment multiplication consumptive water use specific process activity water scarcity implies resultant weighted process activity affected wfs processes activities purpose environmental performance indicator lca treatment inconsistent environmental footprints defined water stress index cited water scarcity metric lca community lacks meaningful physical interpretation proposed incorporate topic freshwater scarcity lca natural resource depletion category considering depletion global perspective since global freshwater demand growing global freshwater availability limited key measure comparative claim different products globe limited accessible usable freshwater flows author published elsevier ltd
increasingly apparent traditional scene graph fulfilling requirements real time interactive systems use single graph representation current state world means display systems may operate different rates may need predict ahead state need tightly integrated behaviour semantics position paper propose type field called ambient field represents information proximate user senses could sample short time periods fields might represent audio video haptic potentially sensed information display device sample fields necessary construct best representation possible display rate ambient field draws concept ambient optical array gibson light fields computer graphics rendering point based physics simulations
normal rotator cuff tendon bone insertion site recreated repair instead normal fibrocartilaginous transition zone repaired tendons heal layer interposing scar tissue alteration biology makes rotator cuff repairs prone failure various methods proposed biologically augment rotator cuff repairs including platelet rich plasma patches stem cells molecular factors cytokines currently insufficient evidence literature support platelet rich plasma augment rotator cuff repair patches used augment recommend gap spanning instrument stem cells cytokines promising animal data sparse data humans suggestive positive outcomes newer possibilities include combinations methods well gene therapy modifiable patient factors smoking cessation glycemic control diabetics limiting use anti inflammatories may readily available ways improve biology rotator cuff healing goals research build preclinical work successes well find novel ways enhance biology repair site improve healing reduce retears
background objectives numerous randomised controlled trials rcts published first tier medical journals evaluated health effects diets high protein conducted rigorous systematic review rcts comparing higher lower protein diets methods searched several electronic databases july studies focusing patient important outcomes example cardiovascular disease secondary outcomes risk factors chronic disease example adiposity results identified articles reporting trials pooled effect sizes using standardised mean differences smds small moderate favoured higher protein diets weight loss smd confidence interval body mass index waist circumference blood pressure systolic diastolic high density lipoproteins hdl fasting insulin triglycerides sensitivity analysis studies lower risk bias abolished effect hdl fasting insulin reduced effect triglycerides observed nonsignificant effects total cholesterol low density lipoproteins reactive protein hbac fasting blood glucose surrogates bone kidney health adverse gastrointestinal events common high protein diets multivariable meta regression analysis showed significant dose response higher protein intake conclusions higher protein diets probably improve adiposity blood pressure triglyceride levels effects small need weighed potential harms
understanding influence non axisymmetric internal frames vibroa coustic behavior stiffened cylindrical shell high interest naval aeronautic industries several numerical studies shown non axisymmetric internal frame increase radiation efficiency significantly case mechanical point force however less attention paid experimental verification statement paper proposes compare radiation efficiency estimated experimentally stiffened cylindrical shell without internal frames experimental process based scanning laser vibrometer measurements vibrations surface shell transform vibratory field wavenumber domain performed allows estimating far field radiated pressure stationary phase theorem increase radiation efficiency observed low frequencies analysis velocity field physical wavenumber spaces allows highlighting coupling circumferential orders origin increase radiation efficiency elsevier ltd rights reserved
diffusion equationof suspended sediment concentration wide sediment laden stream flow dependent vertical gradient streamwise velocity sediment diffusivity study aims investigating influence streamwise velocity laws suspended sediment concentration distributions resulting solution diffusion equation firstly sediment concentration distributions obtained numerically solution diffusion equationusing different velocity laws compared experimental data found power law approximation produces good computational results concentration distributions accuracy using power law velocity model comparable results obtained classical velocity laws namely log law log wake law stratified log law secondly novel analytical solution proposed determination sediment concentration distribution power law wall concentration profile coupled concentration wake function power law model velocity concentration calibrated using experimental data generalized wake function obtained choosing suitable law developed power law model involving wake function adjusted exponent predicts sediment concentration distributions quite satisfactorily finally new explicit formula suspended load transport rate derived proposed theory numerical computation integrals needed einstein theory avoided
many real world information represented graph set nodes interconnected multiple type relations called edge layers social network biological data edge bundling techniques proposed solve cluttering issue standard graphs efforts done deal similar issue multilayer graphs multilayer graphs scenario clutter induced large amount edges problem also fact different type edges overlap making useless final visualization paper introduce new multilayer graph edge bundling technique firstly produces preliminary edge bundling independently different edge layers deals specificity multilayer graphs one type edges routed bundle proposed visualization tested real world case study outcomes point ability proposal discover patterns present data
paper present framework generates network indicators compromise ioc automatically malware sample dynamic runtime analysis framework addresses limitations manual indicator compromise generation utilises sandbox environment perform malware analysis focus generation network based iocs captured traffic files pcaps generated dynamic malware analysis cuckoo sandbox environment used analysis setup described detail accordingly discuss concept iocs popular formats used currently standard example proof concept framework used chose dridex malware samples evaluated traffic showed used generation network based iocs results system confirm create iocs dynamic malware analysis avoid legitimate background traffic originating sandbox system also briefly discuss sharing application generated iocs number systems used share lastly discuss useful combating cyber threats
objective analyze differences psychopathic traits offender non offender youths similar socioeconomic backgrounds method psychopathy checklist revised pcl scale used identify whether young offenders history mental disorders criteria psychopathy exhibited differences total score specifically factor factor scale compared young people living similar socioeconomic conditions committed offenses results observed statistically significant group differences mean pcl scores mean score offender group non offender group also detected significant group differences analyzed mean factor factor scores separately although groups exhibited statistically significant difference educational attainment group comparison mean pcl scores controlling educational attainment analysis covariance ancova showed difference pcl scores remained statistically significant conclusions conclude sample presence primary interpersonal affective characteristics secondary lifestyle antisocial behavior psychopathic traits differed offender non offender youths even excluding psychopathy mental disorders assessments results suggest need wide ranging interventions restricted socioeconomic aspects management juvenile delinquency
purpose study evaluate effects pharmacological non pharmacological topical controls prevention radiation dermatitis relevant clinical trials identified electronic searching databases cinahl central lilacs pubmed scopus web science handsearching gray literature searches also performed find additional references primary outcomes interest development radiation dermatitis time occurrence radiation dermatitis thirteen randomized clinical trials included review trials published chinese english french pharmacological interventions used trials trolamine aloe vera allantoin lianbai liquid sucralfate sucrose octasulfate olive oil hialuronic acid dexpanthenol non pharmacological topical controls usual care institution routine aqueous cream mild soap water thermal gel placebo intervention strong evidence indicates differences topical pharmacological interventions non pharmacological topical controls prevention acute radiation dermatitis among patients head neck cancer undergoing radiotherapy
paper presents method solving cryptarithms variously known alphametics crypto arithmetics arithmetical restorations verbal arithmetic using microsoft excel along solver add order make suitable classroom presentation elements method introduced incrementally first linear program integer linear program finally integer linear program different variables unlike approaches discussed literature brute force method logic programming parallel genetic algorithms method require knowledge computer programming also introduces users excel often neglected integer alldifferent constraints well increase computational time associated constraints
musculoskeletal complaints mscs among adults several risk factors known important determinant earlier episode mscs research shifted younger ages showing high prevalence mscs among children adolescents purpose evaluate prevalence mscs among growing age explore role several sociodemographic growth development psychosocial lifestyle factors data collected age age ongoing dutch prevention incidence asthma mite allergy piama birth cohort study used analyses included multiple logistic regression analyses using stepwise backward selection year prevalence mscs least month increased age age also found upper extremity complaints back complaints lower extremity complaints mscs found among girls sports injuries sleeping problems daytime tiredness although complaints age far important factor associated mscs age pain sites study showed msc already common early age already age factor strongest association earlier episode mscs sleeping problems tiredness may also play role early development mscs either determinant consequence
purpose investigate effectiveness gradient boosting classify endophthalmitis versus uveitis lymphoma intraocular cytokine levels method patient diagnoses aqueous vitreous levels interleukin retrospectively extracted national eye institute histopathology core database compared kruskal wallis post hoc dunn tests gradient boosted decision tree classifier trained differentiate endophthalmitis versus uveitis lymphoma vitreous vitreous aqueous data sets tested train test split fold cross validation training set results seven endophthalmitis lymphoma uveitis patients included higher endophthalmitis uveitis aqueous vitreous lymphoma aqueous vitreous significantly higher lymphoma uveitis aqueous vitreous three fold cross validation demonstrated predictive accuracy vitreous vitreous aqueous data sets upon validation testing set vitreous aqueous data sets achieved predictive accuracy vitreous data achieved predictive accuracy sensitivity specificity area receiver operating characteristic curve roc auc conclusions limited sample size gradient boosting differentiate endophthalmitis uveitis lymphoma high sensitivity specificity however larger cohort needed validation
purpose paper studies influence information communication technologies human reasoning decision making investigates potential impact ambient intelligence change pedestrian mobility behavior using large city scale scenario methods work establishes interplay social technological aspects awareness augmenting model driven framework realistic information eco system distributed multi agent system developed model real life urban mobility environment model simulated using large scale parallel computing platform results evaluation results revealed quality information ambient assisted environments increases compared without ambient intelligence conclusion conclude positive correlation extent information shared socially inspired information eco systems level collective awareness urban mobility scenario
single nucleotide polymorphisms snps tcfl transcription factor like reportedly affect susceptibility schizophrenia scz examined association tcfl polymorphisms scz susceptibility chinese han population six snps genotyped scz patients healthy individuals associations scz evaluated using chi squared test genetic model analyses observed allele associated increased scz risk odds ratio confidence interval adjusted genotype associated higher scz risk genotype adjustment sex age adjusted addition snp associated fold fold fold increases scz risk dominant recessive additive model respectively adjusted bonferroni adjusted adjusted adjusted respectively results suggest significantly associated increased risk scz chinese han population
work presents novel discrete time chaotic systems known physical system non linearities dynamic behaviors models examined numerical methods arduino microcontroller based experimental studies many new chaotic maps generated form high dimensional chaotic systems obtained weak coupling cross coupling different chaotic maps application chaotic maps realized arduino chaotic pulse width modulation drive electrical machines expected new chaotic maps microcontroller implementations facilitate practical chaos based applications different fields
background historically inpatient protocols adopted relatively conservative approaches refeeding anorexia nervosa order reduce risk refeeding syndrome potentially fatal constellation symptoms however increasing evidence suggests patients tolerate higher caloric prescriptions treatment may result prevention initial weight loss shorter hospital stays less exposure effects severe malnutrition therefore present study sought examine effectiveness accelerated refeeding protocol inpatient atypical sample methods participants youth ages atypical hospitalized medical stabilization retrospective chart review conducted assess changes calories weight status percentage median bmi mbmi indicators refeeding syndrome specifically hypophosphatemia hospitalization weight assessed approximately weeks discharge results cases refeeding syndrome observed though participants evidenced hypophosphatemia treatment phosphorous levels monitored participants prescribed supplemental phosphorous time discharge higher rates caloric changes predictive greater changes mbmi hospitalization rates caloric weight change related increased likelihood admission conclusions results suggest accelerated approach inpatient refeeding youth atypical safely implemented associated refeeding syndrome provided close monitoring correction electrolytes findings suggest approach potential decrease length stay burden associated inpatient hospitalization supporting continued progress hospitalization
background chronic psychosocial stress crucial risk factor development many diseases including obesity neuropeptide npy distributed throughout peripheral central nervous system believed pay role pathophysiologic relationship stress obesity although several animal studies investigated impact obesity interactions npy single nucleotide polymorphisms snps stress remains analyzed humans methods identify npygene stress interaction effects human obesity analyzed interaction four npy snps stress obesity related traits including visceral adipose tissue vat total adult subjects included analysis results snp model without interaction stress significant snps found snp however npy snps stress interaction effects significantly linked body mass index bmi waist circumference vat int even though significant interaction effect bmi identified significant interaction effects also detected interaction results binary traits obesity among obesity traits mean changes vat increased stress levels homozygous risk allele carriers greatest range mean increases four snps min max conclusions study suggests common polymorphisms npy associated human obesity interacting psychosocial stress emphasizing need stress management obesity prevention elsevier ltd rights reserved
backgroundavoralstat potent small molecule oral plasma kallikrein inhibitor development treatment hereditary angioedema hae first human study evaluated safety tolerability pharmacokinetics pharmacodynamics avoralstat methodsthis double blind placebo controlled ascending dose cohort trial evaluated avoralstat single doses multiple doses daily every days resultsavoralstat generally well tolerated signals safety concern serious adverse events aes discontinuations due aes compared placebo notable difference aes four moderate severity aes reported two subjects syncope single dose one subject abdominal pain back pain eczema multiple doses avoralstat one subject multiple dose cohorts incidence gastrointestinal aes highest day dose elimination avoralstat exponential terminal half life inhibition plasma kallikrein observed doses degree inhibition highly correlated avoralstat concentrations mean avoralstat concentrations doses met exceeded plasma kallikrein values throughout dosing interval conclusionavoralstat well tolerated drug exposure sufficient meet target levels inhibition plasma kallikrein based results dose selected evaluation patients hae
microtremor survey kind passive source methods uses ambient ground tremors geological investigation compared traditional geophysical methods flexible cost efficient environmentally friendly currently used geophones expensive bulky therefore inconvenient large scale deployment study cable low cost geophone optimized suit large scale microtremor survey method optimization based following four points first selects sensor analysis self noise meet needs microtremor survey second chooses right operational amplifier conversion module third integrates design entire system without using external module fourth makes low cost design geophone system including selection low cost hardware components reducing amount software code finally optimized geophone used three areas different geological conditions order verify rationality improvement possibilities large scale microtremor survey purpose optimization achieved research cable geophone wrights maximum average power cost exceed entire system costs less rmb important thing optimized geophone record microtremor signal effectively experiments show different geological conditions geophone setup quickly work smoothly reliably results microtremor survey experiments consistent existing geological data new geophone much cheaper existing microtremor survey equipment possible use low cost large scale survey optimized geophone small volume light weight rapidly emplacedinto variety detector arrays emplacement large number geophones easily quickly conduct survey two dimensional three dimensional velocity structure area microtremor survey environment friendly low cost advantages broad application prospects
recent field measurements long span bridges typhoon events captured strong nonstationary features buffeting responses study buffeting responses sutong bridge typhoon haikui recorded structural health monitoring system analyzed represent nonstationary characteristics accurately measured state variable acceleration response main girder first selected evaluate original stationarity different time intervals using run test method acceleration response main girder regarded zero mean nonstationary random process demand extract transient features time frequency domain hence evolutionary power spectral density epsd acceleration responses present local turbulence energy distribution frequency time domains estimated using wavelet based method also average wavelet spectrum obtained averaging square values wavelet coefficients along time axis comparison average wavelet spectrum fourier spectrum shows great conformance indirectly verifies validity obtained evolutionary power spectral density results study exhibit strong nonstationary characteristics existing buffeting responses sutong bridge typhoon haikui essential incorporate nonstationary features winds analysis design long span bridges aerodynamic viewpoint
appraisal research traditionally focused negative emotions addressed issues concerning relationships several positive emotions appraisals daily life extent occurrence positive emotions explained overlap appraisals driven priori hypotheses appraisal emotion relationships study investigated positive emotions appraisal dimensions using ecological momentary assessment results provide strong evidence positive emotions appraisals correlate significantly daily life importantly found positive emotions overlap theoretically relevant compared irrelevant appraisals stronger predictive occurrence furthermore appraisal overlap theoretically relevant appraisals predicted occurrence positive emotions even appraisal pleasantness excluded indicating positive emotions occur virtue shared valence findings affirmed refined appraisal profiles positive emotions underscore importance appraisals accounting commonality differences among positive emotions
background asthma disproportionately affects minority populations associated psychosocial stress racial ethnic discrimination aimed examine association perceived discrimination asthma poor asthma control african american latino youth methods included african american mexican american latino puerto rican islander youth aged years genes environments admixture latino americans study study african americans asthma genes environments asthma defined physician diagnosis asthma control defined based national heart lung blood institute guidelines perceived racial ethnic discrimination assessed experiences discrimination questionnaire focus school medical public settings examined associations perceived discrimination outcome whether socioeconomic status ses global african ancestry modified associations results african american children reporting discrimination greater odds experiencing asthma reporting discrimination similarly african american children faced increased odds poor asthma control experience discrimination counterparts reporting discrimination associations observed among latino children observed heterogeneity association reports discrimination asthma according ses reports discrimination increasing odds asthma among low ses mexican american youth interaction among high ses latino youth interaction conclusions perceived discrimination associated increased odds asthma poorer control among african american youth ses exacerbates effect perceived discrimination asthma among mexican american latino youth
rainwater harvesting seen part solution avoid water shortage future offers sufficient supply economical compare conventional way scarcity water supply becoming concern due growing population human along environment pollutions rainwater harvesting considered accessible source could easily used potable purposes household commercial activities therefore study physical microbiological chemical rainwater quality samples analyzed using membrane filtration technique ele paqualab icp oes hach methods ensure suitability rainwater harvesting domestic consumption study reveals overall quality rainwater quite satisfactory per malaysian standards turbidity total dissolved solids salinity still permissible limits however microbiological parameters total coliform fecal coliform coli chemical found exceeded standards due poor hygienic practices harvesting system concluded rainwater harvesting still safe drink potential alternative source water supply future
game development interdisciplinary concept embraces software engineering business management artistic disciplines research facilitates better understanding business dimension digital games main objective research investigate empirically effect business factors performance digital games market answer research questions asked study game development organizations facing high pressure competition digital game industry business become crucial dimension especially game development organizations main contribution paper investigate empirically influence key business factors business performance games first study domain game development demonstrates interrelationship key business factors game performance market results study provide evidence game development organizations must deal multiple business key factors remain competitive handle high pressure digital game industry furthermore results study support theoretical assertion key business factors play important role game business performance elsevier rights reserved
objective understanding treatments work goal psychotherapy research however strength relationships therapy processes outcomes inconsistent derubeis cohen proposed process outcome relationships moderated patient characteristics patient response patterns prps indicate individuals responsiveness active ingredients treatment given quality therapy one individual may receive benefit another depending prp prognosis moderation hypothesis states prps defined pretreatment prognostic indicators medium prognosis groups pliant like stronger process outcome relationships good easy like poor challenging like groups method individuals received unguided computerized cbt women aged years engagement ccbt program process variable prps defined predicted scores prognostic regression model outcomes bdi scores months easy like pliant like challenging like groups created engagement outcome relationship assessed function group results engagement outcome correlations prp easy like pliant like challenging like pliant like group found moderator engagement outcome relationship results similar months faded conclusions engagement outcome relationship varied function prognosis providing support prognosis moderation hypothesis pliant like group appeared sensitive treatment procedures future research needed refine methods identifying prps
asked pick typical human people likely pick man woman phenomenon reflecting androcentrism social media websites provide relevant context study androcentrism since many websites aim provide users ostensibly gender neutral icon users upload one images first study male female online participants age rated whether actual avatar icons highly trafficked social media websites perceived gender neutral using polar scales woman man participants reported overall icons appeared male typed gender neutral study investigated whether adding female typed icons would discourage promote androcentric thinking online sample male female participants age viewed either avatar icons reflected representation male typed icons included equal number male female typed icons participants asked produce example typical person finally measured political ideology two liberal conservative scales found evidence exposure equal number male typed female typed avatar icons generated reactance among political conservatives thus may constituted ideological threat conservatives saw equal number male typed female typed icons twice likely come man typical person compared conservatives saw representation male typed avatar icons consistent system justification theory findings show male centric thinking also evident seemingly gender neutral online context
clinical animal model studies implicated inflammation peripheral immune cell responses pathophysiology alzheimer disease peripheral immune cells including cells circulate cerebrospinal fluid csf healthy adults found brains patients rodent models blocking entry peripheral macrophages cns reported increase amyloid burden mouse model assess inflammation xfad mouse model first quantified central immune cell profiles deep cervical lymph nodes spleen brains mice activated mhcii high lyc high myeloid derived cdb immune cells decreased cells increased function age relative non mice immunological changes along evidence increased mrna levels several cytokines suggest immune regulation trafficking patterns altered mice levels soluble tumor necrosis factor stnf modulate blood brain barrier bbb permeability increased csf brain parenchyma post mortem subjects mice report vivo peripheral administration xpro novel biologic sequesters stnf inactive heterotrimers reduced age dependent increase activated immune cells mice decreasing overall number cells addition xpro treatment vivo rescued impaired long term potentiation ltp measured brain slices association decreased ala plaques subiculum selective targeting stnf may modulate brain immune cell infiltration prevent delay neuronal dysfunction significance statement immune cells cytokines perform specialized functions inside outside brain maintain optimal brain health extent activities change response neuronal dysfunction degeneration well understood findings indicate neutralization stnf reduced age dependent increase activated immune cells mice decreasing overall number cells addition impaired long term potentiation ltp rescued xpro association decreased hippocampal ala plaques selective targeting stnf holds translational potential modulate brain immune cell infiltration dampen neuroinflammation prevent delay neuronal dysfunction elsevier inc rights reserved
social cognition impaired schizophrenia relatively independent purely neurocognitive domains attention executive functioning may strongest predictor functional outcome disease within motivated reasoning framework tested hypothesis anti inflammatory associated cytokines mdc would correlated behavioral measures social cognitive threat detection bias self referential gaze detection bias theory mind tom bias delusional versus non delusional patients administered schizophrenia patients delusions non delusional patients controls social cognitive task designed sensitive psychosocial stress response waiting room task collected plasma levels inflammatory markers using bead based flow immunoassay results partially supported hypothesis anti inflammatory cytokine associated self referential tom bias delusional cohort predicted non delusional patients healthy controls bias reflects documented tendency schizophrenia patients delusions excessively attribute hostile intentions people environment since cytokine correlated tom bias delusional patients elevated levels cytokine blood may eventually serve useful biomarker distinguishing delusional patients non delusional patients healthy controls
design pays much attention analyzing calculating miller capacitor operational amplifier optimist operational amplifier design bit high speed low power pipeline adc based standard cmos technology power supply results show gain operational amplifier gain bandwidth mhz adc achieve bits resolution samples
phenomena associated entrainment free stream turbulence fst boundary layer flows relevant number subjects believed continuous spectra orr sommerfeld squire equations describe entrainment process thus used specify inlet condition simulation bypass transition however dong dong continuous spectra orr sommerfeld squire equations entrainment free stream vortical disturbances journal fluid mechanics pointed continuous spectra exhibit several non physical features due neglecting non parallelism proposed large reynolds number asymptotic approach showed non parallelism leading order effect even short wavelength disturbance response concentrates edge layer paper asymptotic solution verified numerically studying evolution incompressible boundary layers found numerical results accurately predicted asymptotic solution implying latter adequate moderate reynolds numbers introducing series solutions inflow perturbations bypass transition investigated via direct numerical simulation dns transition processes including evolution streaks amplification secondary instability modes emergence turbulent spots agree experimental observations
billions lines sequential code inside nowadays software benefit parallelism available modern multicore architectures automatically parallelizing sequential code promote efficient use available parallelism research goal time work proposes new approach achieving goal created new parallelizing compiler analyses read write instructions control flow modifications programs identify set dependencies instructions program afterwards compiler based generated dependencies graph rewrites organizes program task oriented structure parallel tasks composed instructions executed parallel work stealing based parallel runtime responsible scheduling managing granularity generated tasks furthermore compile time granularity control mechanism also avoids creating unnecessary data structures work focuses java language techniques general enough applied programming languages evaluated approach benchmark programs ooojava achieving higher speedups cases values close manual parallelization resulting parallel code also advantage readable easily configured improve performance manually
paper introduce real time face recognition announcement system targeted aiding blind low vision people system uses microsoft kinect sensor wearable device performs face detection uses temporal coherence along simple biometric procedure generate sound associated identified person virtualized estimated location approach uses variation nearest neighbors algorithm histogram oriented gradient descriptors dimensionally reduced principal component analysis results show approach average outperforms traditional face recognition methods requiring much less computational resources memory processing power battery life compared existing techniques literature deeming suitable wearable hardware constraints also show performance system dark using depth information acquired kinect infrared camera validation uses new dataset available download videos people containing variation illumination background movement patterns experiments existing datasets literature also considered finally conducted user experience evaluations blindfolded visually impaired users showing encouraging results
good evidence gender specific differences asthma regarding affected areas intra extracellular mediators whole organ structure und functioning lung result complex parts synergistic parts opposing effects especially female sex hormones rather asthma protective effects male hormones include effects cellular immune system additionally gender differences sociocultural origin regarding presentation doctors diagnosis treatment asthma symptoms well undertaken coping strategies concerning female male patients complaints taking account gender specific differences asthma would contribute improved individual diagnosis therapies
background chronic kidney disease common associated increased cardiovascular disease risk currently markers renal tubular injury used routinely describe kidney health little known risk cardiovascular events death associated biomarkers independent glomerular filtration based markers serum creatinine albuminuria study design cohort study cric chronic renal insufficiency cohort study setting participants participants estimated glomerular filtration rate min enrolled june august predictor urine neutrophil gelatinase associated lipocalin ngal concentration outcomes adjudicated heart failure event ischemic atherosclerotic event myocardial infarction ischemic stroke peripheral artery disease death march measurements urine ngal measured baseline step assay using chemiluminescent microparticle immunoassay technology architect isr abbott laboratories results heart failure events person years follow ischemic atherosclerotic events person years follow deaths person years follow cox regression models adjusted estimated glomerular filtration rate albuminuria demographics traditional cardiovascular disease risk factors cardiac medications higher urine ngal levels remained associated independently ischemic atherosclerotic events adjusted highest lowest quintile per unit increase log urine ngal heart failure events deaths limitations urine ngal measured conclusions among patients chronic kidney disease urine levels ngal marker renal tubular injury associated independently future ischemic atherosclerotic events heart failure events deaths national kidney foundation inc published elsevier inc rights reserved
previous experiments demonstrated social isolation caused like tau hyperphosphorylation spatial memory deficits middle aged rats however underlying mechanisms induced spatial memory deficits remain elusive middle aged rats months group isolation reared weeks following initial week period rearing citalopram administered days pathophysiological changes assessed performing behavioral biochemical pathological analyses found could cause cognitive dysfunction decrease synaptic protein synaptophysin psd expression different brain regions associated cognition prefrontal cortex dorsal hippocampus ventral hippocampus amygdala caudal putamen entorhinal cortex posterior cingulate citalopram could significantly improve learning memory partially restore synaptophysin psd expression prefrontal cortex hippocampus amygdala rats moreover decreased number dendritic spines prefrontal cortex dorsal hippocampus ventral hippocampus could reversed citalopram furthermore reduced levels bdnf serine phosphorylated akt active form serine phosphorylated gsk beta inactive form significant changes levels total gsk beta akt dorsal hippocampus posterior cingulate results suggest decreased synaptic plasticity cognition associated regions might contribute induced cognitive deficits citalopram could ameliorate deficits promoting synaptic plasticity mainly prefrontal cortex dorsal hippocampus ventral hippocampus bdnf akt gsk beta pathway plays important role regulating synaptic plasticity rats
number studies aiming establish relationship physical tactical psychological type variables incidence sports injuries aim paper assess influence anxiety self esteem development physical injuries practising sport regard participation football study allowed record assess variables age sports injury field position anxiety state trait measured spielberger gorsuch lusbene questionnaire results yield statistically significant differences sports injuries anxiety state trait variables prove relationship sports field position main conclusion advocate necessity studies elucidation psychological variables may prevent sports injuries
study examines energy use economic growth nexus disaggregating energy use two types energy renewable non renewable energy use sample consists eleven mena net oil importing countries noics period multivariate panel framework used estimate long run relationship panel granger causality tests employed assess causality direction among variables empirical results provide evidence long term equilibrium relationship real gross domestic product gdp renewable energy use non renewable energy use real gross fixed capital formation labor force results provide evidence also positive statistically significant elasticities moreover empirical findings panel error correction model confirm existence bidirectional causality renewable energy use economic growth non renewable energy use economic growth results support feedback hypothesis moreover empirical findings provide evidence two way bidirectional causal association short long run renewable non renewable energy use proves substitutability interdependence two types energy sources policies implications results also proposed discussed
study focuses evolving integrated water management plan iwmp shimla city erstwhile summer capital british india presently state capital himachal pradesh total water demand million litres per day mld system capacity mld present deficit mld may amplify mld resource assessment related watersheds namely ashwani nauti giri pabbar accomplished using remote sensing techniques geographic information system gis based arc swat hydrological model average annual precipitation watersheds years flows runoff groundwater evapotranspiration ungauged watersheds water balance equation considered validation criteria coefficient correlation observed rainfall simulated runoff varies results validated actual measurement inflow lean period one major sources giri river shown good correlation simulated observed stream flow study establishes existing sources sustainable iwmp suggests source augmentation coupled rainwater harvesting reuse wastewater long term strategic measures
automated control systems irrigation recent years made considerable progress offering wide range new options experiment drip irrigation system automatically governed irrigation accordance water level sensing system mini pan help evaporation data acquisition performed electronic circuit processed data sent data microcontroller picf system closed loop control system based sensing water level mini pan used activate irrigation thereby system started irrigation whenever water level mini pan dropped set level performance automated system increased irrigation timing software adjusted according plant growth stages
turner syndrome rare genetic disease due absence one chromosome patients subtle neurological neuropsychiatric problems headache uncommon clinical presentation needs attention report year old child presenting typical cough headache magnetic resonance imaging revealed chiari malformation associated best knowledge chiari malformation associated described literature report first case associated chiari malformation interestingly chiari malformation also associated noonan syndrome close morphological mimicker raising possibility sharing similar pathogenesis conditions
transformation essential thrombocythemia myelodysplastic syndromes acute myeloid leukemia infrequent comprising cases dismal clinical outcome studies prognosis patients leukemic transformation limited large cohort included patients transformation median age years median time diagnosis transformation months median follow time years advanced age myelofibrosis grade leukocytosis time transformation associated inferior transformation given rarity clinical scenario multicenter efforts encouraged elsevier ltd rights reserved
objective determine association new onset atrial fibrillation outcomes including icu length stay survival design retrospective cohort icu admissions found atrial fibrillation using automated detection min classed new onset prior diagnosis atrial fibrillation identified determinants new onset atrial fibrillation using propensity matching characterized impact outcomes setting tertiary care academic center patients total consecutive adult admissions either medical surgical trauma burn icu available continuous electrocardiogram data interventions none measurements main results patient years every minute observations detected atrial fibrillation admissions median burden less atrial fibrillation paroxysmal less admissions always atrial fibrillation new onset atrial fibrillation sub clinical went undocumented icu admissions advanced age acute respiratory failure sepsis strongest predictors new onset atrial fibrillation propensity adjusted regression analyses clinical new onset atrial fibrillation associated increased hospital mortality odds ratio longer length stay new onset atrial fibrillation associated survival hospital discharge hazard ratio hazard ratio respectively subclinical clinical new onset atrial fibrillation conclusions automated analysis continuous electrocardiogram heart rate dynamics detects new onset atrial fibrillation many icu patients though often transient frequently unrecognized new onset atrial fibrillation associated poor hospital outcomes
suicidal behavior associated deficient serotonin neurotransmission likely consequence individual genetic architecture exposure environmental factors interactions factors examined whether interaction child abuse tph tryptophan hydroxylase variant affecting alternative splicing editing tph pre mrnas adarb adenosine deaminase acting rna variants may influence risk suicide attempt psychiatric patients tph genotyped suicide attempters suicide non attempters diagnosed major depressive disorder bipolar disorder schizophrenia genotyping data adarb variants taken previous study child abuse age years assessed using early trauma inventory self report generalized linear models backward selection applied identify main interacting effects environmental genetic factors including psychiatric diagnoses patients gender age covariates childhood general traumas independently associated suicide attempt two way interaction tph general traumas revealed homozygotes history general traumas increased risk suicide attempt three way interaction general traumas tph adarb indicated highest predisposition suicide attempt observed individuals experienced general traumas homozygote homozygote findings suggest risk suicide attempt psychiatric patients exposed adverse childhood environment may depend tph adarb variants
context oxidative stress important factor modulating skin alterations melochia arenosa benth malvaceae brazilian plant antimicrobial activity antioxidant potential objective objective study develop topical formulation containing antioxidant phenolic rich extract arenosa evaluate skin permeation profile materials methods response surface methodology used maximize total phenolic content extract antioxidant activity evaluated diphenyl picryl hydrazyl dpph azinobis ethylbenzothiazoline sulfonic acid abts respiratory burst methods emulsion containing optimized extract developed employed photoacoustic spectroscopy pas determination skin permeation profile morphology skin studied histological sections stained hematoxylin eosin results discussion optimum conditions predicted major extractive efficiency phenolics ethanol led extraction time plant solvent proportion presented gae extract scavenging capacity dpph value abts radicals value production ros neutrophils stimulation phorbol miristate acetate lower present reaction medium endorsing high antioxidant capacity data obtained pas indicated present emulsion permeated distributed whole skin histopathological alterations observed histological analysis conclusion formulation developed promising tool skin care could prevent damage caused oxidative stress
paper presents results laboratory model tests carried embedded square footing supported geotextile reinforced sand bed effect reinforcement geotextile studies series laboratory model tests different size geotextile depth placement footing effects prestressing geotextile strength improvement settlement reduction reinforced sand bed also investigated model steel tank size square footing used study also highlights effect size geotextile placement geotextile footing load settlement characteristics
building energy simulation programs cases solve heat conduction walls considering one dimensional heat flows neglecting thermal bridges paper shows new method implementing dimensional three dimensional heat transfer dynamic energy simulation software allowing great improvement capabilities new procedure starts theory state space representation transfer functions introduces simplifications reducing computational time required cpu sources starting first case study aimed verify achievable correspondence simplified new method compared original one two common thermal bridges deeply analysed comparing proposed methodologies numerical solution based using finite volume methods investigated building structures determine dimensional heat flows discontinuities materials geometry comparing achieved outcomes derived much onerous cfd studies several cases changing grid refinement timestep ambient condition proposed method shows suitability maximum errors never higher also hourly variable outdoor temperature solar radiation elsevier ltd rights reserved
rainwater harvesting systems used households commercial buildings comes independent system disconnected drinking water system directly measured conventional drinking water meters installed pipes public system therefore used volumes properly measured paper presents methodology estimate rainwater loading discharged sewage systems means harvesting practices households estimation indexed drinking water meter toilet flush adopted object analysis results pointed efficiency system varies whose correspond values varying inhab dia keeping fixed reservoir volume inhab ranges per capita consumption sewage represented values lower total demand considering specific roof inhab hand reservoir harvesting systems bigger inhab roof inhab enough plenty supply toilet flush based inhab consumption general terms correction factor proposed estimating wastewater discharge new scenario considering harvesting varies corrigido new ratio given wastewater inlet drinking water varied corrigido
paper analyze security recent image encryption algorithm based improper fractional order chaotic system suggested zhao fatal flaw cryptosystem keystream generated depends neither plain image cipher image another main issue algorithm using key last key keystream encryption equations based points easy recover plain image keystream applying chosen plaintext attack one plain image mathematical analysis experimental results confirm feasibility attack result cryptosystem study suitable cryptography
cloud computing offers possibility store process massive amounts remotely sensed hyperspectral data distributed way dimensionality reduction important task hyperspectral imaging hyperspectral data often contains redundancy removed prior analysis data repositories regard development dimensionality reduction techniques cloud computing environments provide efficient storage preprocessing data paper develop parallel distributed implementation widely used technique hyperspectral dimensionality reduction principal component analysis pca based cloud computing architectures implementation utilizes hadoop distributed file system hdfs realize distributed storage uses apache spark computing engine developed based map reduce parallel model taking full advantage high throughput access high performance distributed computing capabilities cloud computing environments first optimized traditional pca algorithm well suited parallel distributed computing implemented real cloud computing architecture experimental results conducted using several hyperspectral datasets reveal high performance proposed distributed parallel method
gut densely inhabited commensal bacteria metabolize dietary fibers undigested carbohydrates produce short chain fatty acids acetate gpr one receptors sense short chain fatty acids expressed various immune non immune cells acetate gpr signaling shown affect various inflammatory diseases responses nadph oxidase nox derived reactive oxygen species ros generation however study previously explored effects gpr activation psoriasis like inflammation therefore study investigated effect acetate phenylacetamide gpr agonists imiquimod induced skin inflammation mice mice administered phenylacetamide acetate followed assessment skin inflammation noxs nox nox dual oxidases related signaling study showed induction epidermal gpr imiquimod treatment psoriasis like inflammation acetate administration psoriatic mice led increase skin inflammation ear thickness myeloperoxidase activity concurrent increase immune responses epidermal dual oxidase signaling topical application gpr agonist phenylacetamide led enhanced ear thickness concomitant epidermal signaling well dual oxidase upregulation may responsible increased psoriasis like inflammation taken together dual oxidase play important roles gpr mediated skin inflammation current study suggests gpr activation psoriatic patients may lead aggravation psoriatic inflammation elsevier inc rights reserved
protein homeostasis proteostasis requires timely degradation misfolded proteins aggregates protein quality control pqc molecular chaperones essential component compared cell types pqc neurons particularly challenging unique cellular structure long extensions making worse neurons postmitotic dilute toxic substances division thus highly sensitive misfolded proteins especially age failure pqc often associated neurodegenerative diseases huntington disease alzheimer disease parkinson disease prion disease fact many neurodegenerative diseases considered protein misfolding disorders prevent accumulation disease causing aggregates neurons utilize repertoire chaperones recognize misfolded proteins exposed hydrophobic surfaces assist refolding effort fails chaperones facilitate degradation terminally misfolded proteins either ubiquitin proteasome system ups autophagy lysosome system hereafter autophagy soluble substrates associated chaperones hsp ubiquitinated ligases degraded proteasome complex misfolded proteins carrying kferq motif recognized chaperone hsc delivered lysosomal lumen process called chaperone mediated autophagy cma aggregation prone misfolded proteins remain unprocessed directed macroautophagy cargoes collected adaptors sqstm sequestosome delivered autophagosome lysosomal degradation aggregates survived refolding degradative processes still directly dissolved disaggregated chaperones studies shown molecular chaperones alleviate pathogenic symptoms neurodegeneration causing protein aggregates chaperone inducing drugs anti aggregation drugs actively exploited beneficial effects symptoms disease discuss chaperones protectmisfolded proteins aggregation andmediate degradation terminallymisfolded proteins collaboration cellular degradative machinery topics also include therapeutic approaches improve expression turnover molecular chaperones develop anti aggregation drugs
first principle neural network discussed traditional network learning algorithm neural network adaptive learning algorithm researched combining advantages two algorithms distributed neural network self learning algorithm proposed kind intrusion detection algorithm using method distributed learning optimize neural network algorithm using algorithm study test network intrusion data solves problem directly using learning caused training sample size large difficult convergence time sample training time shortened neural network classification accuracy improved secondly based research improved algorithm paper gives specific steps algorithm uses improved algorithm establish mathematical model used analyzing forecasting compared traditional network learning algorithm neural network adaptive learning algorithm verify effectiveness feasibility improved algorithm finally algorithm applied intrusion detection appropriate test method use sample data paper adopted verify example results testing data verifies performance distributed neural network self learning algorithm comes conclusion
osteoarthritis degenerative disease characterized deterioration articular cartilage aim study identify characterize expression microrna mir normal synovial cells determine role pathogenesis first levels mir synoviolin syvn detected among normal mild severe groups use quantitative pcr computational analysis used search target mir luciferase reporter assay system used validate syvn target gene mir syvn expression level cells transfected mir mimics inhibitors estimated using quantitative pcr western blotting finally mtt assay employed estimate effect mir apoptosis enrolled participants consisting normal control mild severe furthermore performed quantitative pcr detect levels mir syvn among groups found mir expressed highest level severe compared normal control mild groups syvn expressed lowest level severe additionally identified syvn target mir using computational analysis luciferase assay transfection mir mimic inhibitor employed investigate effect mir expression syvn synovial cells synovial cell viability apoptosis results showed mir mimics significant decreased expression syvn substantially promoted apoptosis synovial cells mir inhibitors remarkably increased level syvn substantially suppressed apoptosis synovial cells data suggested mirb promoted apoptosis synovial cells targeting syvn gene important implication validating mir potential target therapy
longitudinal stiffness multispan suspension bridges plays important role load resisting systems paper model defined kinematic multispring kms model proposed simulating longitudinal deformation behavior multispan suspension bridges tower springs cable springs constitute series parallel system kms model stiffness formulas cable springs derived basis energy principle elastic elongation cable considered proved nonnegligible especially long span bridges effect inclined angle cables first considered formulas cable elastic stiffness elastic stiffness geometric stiffness cables found relevant compared numerical models kms model proposed paper proven accurate applicable
propose ssketch novel automated framework efficient analysis dynamic big data dense non sparse correlation matrices reconfigurable platforms ssketch targets streaming applications data sample processed storage severely limited framework adaptively learns stream input data updates corresponding ensemble lower dimensional data structures sketch matrix new sketching methodology introduced tailors problem transforming big data dense correlations ensemble lower dimensional subspaces suitable hardware based acceleration performed reconfigurable hardware new method scalable significantly reduces costly memory interactions enhances matrix computation performance leveraging coarse grained parallelism existing dataset ssketch provides automated optimization methodology creating accurate data sketch given set user defined constraints including runtime power well platform constraints memory facilitate automation ssketch takes advantage hardware software design approach provides application programming interface customized rapid prototyping arbitrary matrix based data analysis algorithm proof concept evaluations variety visual datasets million non zeros demonstrate fold speedup hardware accelerated realization ssketch compared software based deployment general purpose processor
original prospective cohort study conducted attempt significantly reduce incidence severity injuries intervention cohort compared two season historical cohort provide recommendations international federation football ifaf pertaining prevention measures make game safer total amateur male mean age years female mean age years players participated study four prevention measures implemented pocket rule self fitting mouth guards ankle braces players recurrent ankle sprains injury treatment information brochure time loss injuries sustained game sessions recorded field medical personnel followed detailed phone injury surveillance questionnaire reduction total number injuries significant reduction incidence rate incidence proportion intervention cohorts compared historical cohort statistically significant reduction number injuries body parts except hand wrist injuries related use pockets well severity mild moderate injuries study provided evidence hand wrist injuries significantly reduced flag football recommendations ifaf include strict enforcement pocket rule use soft headgear comfortable fitting ankle braces mouth guards additionally change game rules concerning blocking
leptin adipocyte derived cytokine secreted mostly adipose tissue serum leptin levels elevated obese individuals correlate positively body mass index bmi interestingly serum leptin levels also elevated patients psoriasis correlate positively disease severity psoriasis associated obesity patients psoriasis higher incidence obesity obese individuals higher risk developing psoriasis additionally obese patients psoriasis experience severe degree psoriasis study hypothesised leptin may link psoriasis obesity plays aggravating role psoriasis investigate leptin role psoriasis applied widely accepted imiquimod imq induced psoriasis like skin inflammation mouse model leptin deficient mice evaluated psoriasis severity moreover stimulated human keratinocytes leptin investigated effect proliferation expression pro inflammatory proteins mice clinical signs erythema infiltration scales dorsal skin inflammation ear skin measured ear thickness attenuated compared mice moreover mrna expression levels well increased epidermal thickness significantly less induced vitro effect leptin stimulation human keratinocytes demonstrated increased proliferation induced secretion several pro inflammatory proteins two hallmarks psoriasis conclusion leptin deficiency attenuated imq induced psoriasis like skin inflammation mouse model leptin stimulation induced pro inflammatory phenotype human keratinocytes thus supporting aggravating role leptin psoriasis
dnaj proteins function molecular chaperone played critical roles plant growth development response heat stress also called heat shock protein based molecular weight however little reported gene family pepper recently release whole pepper genome provided opportunity identifying putative dnaj homologous study total putative pepper dnaj genes cadnaj cadnaj identified using bioinformatics methods classified five groups presence complete three domains domain zinc finger domain terminal domain chromosome mapping suggested segmental duplication tandem duplication occurred evolution multiple stress related cis elements found promoter region cadnaj genes indicated cadnajs might involved process responding complex stress conditions addition expression profiles based rna seq showed cadnajs expressed least one tissue tested result implied could involved process pepper growth development qrt pcr analysis found cadnajs induced indicated could participated pepper response high temperature treatments conclusion results would provide comprehensive basis analyzing function cadnaj members also significant elucidating evolutionary relationship pepper
background evidence suggests relationship personality disorder violence offenders might clarified considering subgroups offenders defined patterns comorbidity aim identify patterns comorbidity associated severe violence defined severity quantity age onset violence index forensic sample offenders methods correlations first computed range personality criminological variables next patients antisocial borderline comorbidity compared patients finally regression analysis conducted identify unique predictors results antisocial deviance factor psychopathy antisocial borderline comorbidity significantly independently associated severe violence patients showing high psychopathy score antisocial borderline comorbidity significantly greater without characteristics conclusion patients high psychopathy occurring borderline antisocial pds show criminal profile characterised high degree serious violence
concept signal noise ratio snr enhancement impulse radio transceivers based phasers opposite chirping slopes introduced shown snr enhancements factors achieved burst noise gaussian noise respectively stretching factor phasers experimental demonstration presented using stripline cascaded section phasers snr enhancements agreement theory obtained proposed radio analog signal processing transceiver system simple low cost frequency scalable may therefore suitable broadband impulse radio ranging communication applications
replacement conventional energy sources renewables solar panels wind turbines requires adequate land impact assessments conducted identify sites exhibiting least conflict current future land uses corresponding ecosystem services assessed electricity potential geographical distribution wind turbines solar panels current land use three swiss land change scenarios future scenario limited construction regulations liberalized market building surfaces increases electricity potential solar panels twh potential current land use regulations future twh increase approximately electricity potential solar panels expected scenario regionalized economy trend scenario wind electricity potential could increase twh trend scenario electricity potential solar panels remains largely unaffected conflicts ecosystem services electricity production wind could reduced much due conflicts ecosystem services depending scenario used low conflict sites solar panels wind turbines could contribute trend scenario scenario swiss energy target generating twh new renewable energy sources includes expected technological developments positive impacts sustainable energy production regional economies moderate lead strong changes regional economic development
nonsuicidal self injury nssi prominent individuals borderline personality disorder bpd abundant evidence affect regulation plays important role nssi majority patients affective variability core feature bpd thus hypothesize nssi affect stabilization function bpd affect stabilization process individuals attempt make affect stable reducing affective variability tested hypothesis participants bpd reported nssi affect using displeasure pleasure valence activation deactivation activation dimension experience sampling study random signals scheduled per day days results indicated individuals engaged nssi show within subject variance valence activation individuals engage nssi however within nssi patients individuals engaged frequently nssi study showed less variance valence activation patients engaged less frequently nssi suggests nssi may reinforced affect stabilization function discussion explore alternative explanations relation nssi affective variability consider clinical implications elsevier ltd rights reserved
identification hammerstein nonlinear models received much attention due ability describe wide variety nonlinear systems novel identification approach based intelligent optimal weighted least squares svm wlssvm proposed hammerstein system new adaptive particle swarm optimization algorithm apso using evolutionary state estimation technique mutation operator applied proposed method fast convergence global optimal solution also good identification results comparison researches carried among proposed method wlssvm lssvm riv methods detail research results show effectiveness proposed apso wlssvm method franklin institute published elsevier ltd rights reserved
significant progress made characterizing biological changes occurring preclinical alzheimer disease cognitive dysfunction viewed however late stage phenomenon despite increasing evidence changes may detected decades preceding dementia absence comprehensive evidence based guidelines preclinical cognitive assessment longitudinal cohort neuroimaging studies reviewed determine temporal order brain biomarker correlates specific cognitive functions episodic memory decline observed salient cognitive function correlating high levels amyloid deposition hypoconnectivity across large scale brain networks prospective studies point early decline episodic semantic memory processing well executive functions predementia period cognitive tests however principally used diagnose dementia new procedures required target finely medial temporal lobe subregions first affected clinically silent pathology alzheimer association published elsevier inc rights reserved
technical advancements manufacturing engineering led development advanced materials improved mechanical properties materials required perform consistently aggressive atmospheres without premature failure ensure reliable performance service life materials subjected different nondestructive tests ndt ensure materials free discontinuities dimensions less critical discontinuity size though conventional film radiography still used ndt industry advanced radiologic techniques explored alternative film radiography phosphor image plate based computed radiography latest development direction image produced using system digital format processed extract information paper describes weld testing using image plate based computed radiography system use image processing evaluation
objectiveindividuals anorexia nervosa restrict fat intake geiselman food preference questionnaire fpq validated self report instrument yields fat preference score high fat preference low fat preference goal study assess utility fpq patients specific aims examine change fat preference scores weight restoration hospitalized patients compare patients scores weight restoration scores healthy participants hps methodthe fpq completed patients hps resultscompared hps patients significantly lower fat preference scores weight restoration fat preference scores increased weight gain normalize discussionacutely weight restored patients continue endorse decreased preference high fat foods fpq may useful metric assess improvements diet treatment study warranted validate fpq observed food intake wiley periodicals inc int eat disord
costimulatory inhibitors abatacept belatacept effectively abrogate lymphocyte activation proliferation shown effective disease control certain autoimmune disorders well preventing allograft rejection kidney transplantation whether immunomodulatory agents may useful control autoimmune flares allograft acceptance avoiding need additional strong immunosuppressants shown report first case year old man affected serious debilitating form psoriatic arthritis presented course third high immunological risk kidney transplantation three years transplantation patient benefited switching tacrolimus belatacept based therapy without additional immunosuppression showing complete regression arthritic symptoms well progression severe radiological lesions leaded recovery disability functional impairment remarkably treatment belatacept association mycophenolate mofetil steroids also provided stable normal allograft function time abrogated development novo circulating donor specific alloantibodies years follow case report describes successful clinical radiological response severe form psoriatic arthritis belatacept conversion highly sensitized kidney transplant patient
objective relationship education usually conceived relationship enhancement currently satisfied couples goal helping couples sustain satisfaction however also might useful brief indicated intervention couples low satisfaction current study evaluated effect couples low high relationship satisfaction method study randomized controlled trial couples randomly assigned book reading control condition control relate online assessment feedback relationship goal setting relate relate couplecare rcc flexible delivery skill based education program couples assessed relationship satisfaction individual mental health year follow results couples high initial satisfaction showed effects satisfaction rcc relate increased satisfaction couples low initial satisfaction effects dissipated months effects mental health conclusion flexible delivery produces immediate effects indicated early intervention couples low relationship satisfaction effects attenuate future research needs seek methods produce better maintained effects
aim article determine experiment large scale models probability direct lightning strikes overhead lines protected wires different model configurations experimental results allowed refute hypothesis absence direct impacts protected wires overhead lines studies conducted suggest lightning defeat overhead lines protected wires substantially lower traditional lines
primary myelofibrosis pmf associated pruritus often severe requires treatment fifty one patients bone marrow proven pmf associated pruritus identified primary cohort patients pmf seen institution conducted retrospective review clinical characteristics severity pruritus type treatment response patients thirty two patients reported severe pmf associated pruritus required total treatment episodes complete response partial response response observed episodes respectively common treatment categories included jak inhibitors anti depressants antihistamines highest rates observed patients treated jak inhibitor immunomodulatory drugs imids emerging targeted therapies may result better symptom control higher response rates patients suffering severe pmf associated pruritus
elementary strength materials core undergraduate engineering course introduces mechanics deformable bodies traditionally focus course analysis recast course apply analysis design order better prepare students become engineers design primary function practicing engineers semester long design project implemented provide opportunity students practice design student teams design playground equipment including conceptual layout material selection load specification design analysis drawings cost estimate final report web site created facilitate administration project provide links data sources give design analysis examples paper summarizes design project tools created ease time burden associated project focus assessment effectiveness project results assessment three semesters penn state positive analysis data indicates students completed course design emphasis better skilled design perform equally analysis relative students completing traditional strength materials course
satellite communications korea driven mainly kcc korea communications commission small scale compared korea space development program organized mest ministry education science technology public civilian satcom sector led mainly etri small medium companies contrary rare investment private sector military sector orchestrated add defense industry coms communication ocean meteorological satellite experimental band payload korea pursues space qualification technology national infrastructure evolution well industrialization space results coms launched space qualified subsequent application experiments new technology like uhdtv entail service industry promotion payload technology expected next korean commercial satellites new obp satellites coms ground control system gnss ground station technologies development coms operation enhanced gnss services along advent galileo respectively satellite broadband mobile vsat based dvb rcs low profile tracking antennas developed trains ships planes apsi developing gmr based thuraya handset functions etri designing imt advanced satellite radio interface satellite terrestrial dual mode handheld communication system like japanese stics universities satellite ofdm researches ghz band higher availability scalable broadcasting technology skylife hybrid satellite iptv technology developed near term korea extend programs upgrade space communication infrastructure universal access digital opportunity safer daily life disaster promote space green industrialization national security space resources sovereign japanese stakeholders invited establish collaborative korea mutual benefit future
study designed path planning method based fuzzy algorithm genetic fuzzy algorithm security patrol robot firstly fuzzy algorithm design path planning introduced included making obstacle avoidance control strategy establishing fuzzy language membership function input output establishing fuzzy control rules path planning carrying fuzzy reasoning defuzzification path planning although fuzzy logic algorithm avoid obstacle well path planning need membership function control rules accurately affecting application fuzzy reasoning therefore genetic algorithm used optimize fuzzy algorithm included description model determining range variation parameter encoding scheme algorithm flow designing fuzzy logic controller based genetic algorithm optimization finally order verify effectiveness designed genetic fuzzy algorithm simulation carried
paper presents dynamic fuzzy stochastic neural network model nonparametric system identification using ambient vibration data model developed handle two types imprecision sensed data fuzzy information measurement uncertainties dimension input vector determined using false nearest neighbor approach bayesian information criterion applied obtain optimum number stochastic neurons model fuzzy means clustering algorithm employed data mining tool divide sensed data clusters common features fuzzy stochastic model created combining fuzzy clusters input vectors radial basis activation functions stochastic neural network natural gradient method developed based kullback leibler distance criterion quick convergence model training model validated using power density pseudospectrum approach bayesian hypothesis testing based metric proposed methodology investigated numerically simulated data markov chain model two story planar frame experimentally sensed data ambient vibration data benchmark structure elsevier ltd rights reserved
background patients migraine often experience balance impairments however relationship clinical features like aura chronicity severity balance impairments well established objective study assess balance impairments different subgroups migraine patients method one hundred five subjects diagnosed according ichd iii recruited study uniformly distributed among three groups migraine aura migraine without aura chronic migraine thirty five controls also recruited study balance impairments assessed subjects via modified sensory organization test limits stability test results four groups compared using ancova tests age bmi presence dizziness level physical activity time migraine onset medication intake covariates results subjects migraine aura chronic migraine groups showed poorer balance control control subjects three four conditions tested using modified sensory organization test firmce foamoe foamce foamoe foamce conditions groups also showed poorer postural control subjects migraine without aura group differences control subjects subjects migraine groups found reaction time movement velocity endpoint excursion maximal excursion parameters conclusion evidence balance control impairments subjects subtypes migraine compared control subjects presence aura frequent migraine attacks reflect negatively postural control performance may significant clinical impact patients migraine addressed appropriate clinical interventions
cylindrical algebraic decomposition cad standard tool symbolic computation paper use compute bound convergence rate numerical method usually merely resolved numerical interpolation applying cad allows determine exact bound given formula large simply plugged hence combination reformulating guess prove splitting subproblems necessary paper work details symbolic local fourier analysis particular multigrid solver applied particular optimization problem constrained partial differential equation pde constrained optimization problem even though proposed approach applicable different kinds problems different kinds solvers approach based local fourier analysis local mode analysis widely used straight forward method analyze convergence numerical methods solving discretized systems partial differential equations pdes analysis requires determine supremum rational function apply cad elsevier rights reserved
hypertrophic pachymeningitis important neurologic complication granulomatosis polyangiitis gpa formerly wegener granulomatosis aim study investigate clinical features radiological findings diagnostic pitfalls gpa related retrospective chart review performed screen patients diagnosed gpa samsung medical center neurologic manifestation laboratory findings neuroimaging data clinical course evaluated patients characteristics patients compared patients without sixty five patients gpa identified twenty five patients central nervous system involvement second common radiologic finding neurologic findings included stroke granulomatous disease patients lower incidences systemic manifestations lung kidney without six patients gpa related mpo anca positive two anca patients presented headache rate similar primary headache disorders migraine tension type stabbing secondary headache disorders postural type meningitis patients rarely neurologic deficits different clinical radiologic features may observed gpa related early recognition accurate diagnosis gpa related needed addition neuroimaging findings
engineering analyses based results numerical simulation enable shortening duration reducing costs development tests equipment models prototypes numerical modeling methods uncertainties experimental verification required literature many examples application numerical modelling thermal processes occurring electric motors experimental methods model validation well described work numerical experimental investigations heat conduction finned housing electric motor comparison results presented geometrical model motor rated imported comsol multiphysics software package defining thermophysical properties housing material heat flows generated motor setting boundary conditions numerical model heat conduction motor housing obtained model allowed calculate steady state temperature distribution housing cross section order validate model investigations temperature distribution carried using flir thermovision camera steady state temperature distribution surface housing motor run idling conditions recorded thermography obtained thermograms found satisfactory quantitative agreement simulated temperature distribution real values temperature differences measured across housing cross section deviated calculated ones research confirmed thermovision camera efficient experimental tool validation numerical models heat transfer phenomena finned housing electric motor elsevier ltd rights reserved
circles support accountability cosa group trained supervised volunteers support sex offender core member circle aim supporting core member transitions toward full desistance prospective multi method design used explore psychological social transitions core members data collected start circle months months qualitative data collected semi structured interviews core members total professionals analyzed kwalitan computer assisted program qualitative data analysis quantitative data assessed self report questionnaires sex offenders mean differences tested repeated measures anovas qualitative results indicated improvements reflective skills openness problem solving skills well social skills agency self regulation quantitative results documented improvements emotion regulation internal locus control positive trends self esteem coping skills due small sample size results must interpreted caution core members well professionals reported unique contribution circles process claim needs confirmation
printing combination printing technology printable smart materials provides potential automating actuation devices paper used modifiedfused deposition modelling printing technology fabricate double layer laminate smart material activated temperature directly electric circuit indirectly double layer laminate mathematical model developed describe bending behaviour caused mismatch strain surface layer basal layer electrocaloric deformation testings performed find different bending rules low cost printed active composite different physical states considerable maximal deformation values deformation force carbon fibre polylactic acid specimens polyether ether ketone specimens paper provide double layer smart material printing method prospective applied biomimetic sensors actuators transducers artificial muscles
analysis software architecture plays important role understanding system structures facilitate proper implementation user requirements despite importance software engineering practice lack formal description verification support domain hinders development quality architectural models tackle problem work develop approach modeling verifying software architectures specified using monterey phoenix architecture description language capable modeling system environment behaviors based event traces well supporting different architecture composition operations views first formalize syntax operational semantics therefore formal verification models feasible second extend support shared variables stochastic characteristics increases expressiveness also widens properties check quantitative requirements third dedicated model checker implemented automatic verification models supported finally several experiments conducted evaluate applicability efficiency approach
useful object commonly made selected engineering materials proper shape dimension selection materials manufacturing processes important criterion towards production useable affordable objects technologies behind knowledge needed acquire study proper education practical training scientific research related materials manufacturing engineering mme allah swt sources power knowledge bestowed guide book holy qur beloved messenger prophet mohammad pbuh mankind allah swt narrated various stories many surahs noble qur related applied science technology paper attempt view integration revealed knowledge science technology based knowledge related engineering materials manufacturing processes finally stresses given acquire knowledge science technology based education understanding disseminate cause humanity
objective objective study investigate fatigue cognitive impairments systemic lupus erythematous sle relation diffuse white matter microstructural brain damage methods diffusion tensor mri used generate biomarkers brain white matter microstructural integrity obtained patients sle age matched controls fatigue cognitive function assessed related sle activity clinical data plasma biomarkers inflammation endothelial dysfunction results fifty one patients sle mean age years included mean diffusivity significantly higher white matter fibre tracts sle patients versus age matched healthy controls fatigue sle higher normal reference range associated lower depression anxiety higher body mass index adjusted analyses poorer cognitive function associated longer sle disease duration higher adjusted analysis higher levels meta analysis studies including present study confirmed patients sle higher controls conclusion patients sle microstructural brain white matter damage age general population explain increased fatigue lower cognition sle association raised worse current cognitive function sle explored larger datasets
objectives inappropriate discipline harsh physical punishment social determinant health objective determine brief parent training intervention teaches discipline strategies culturally sensitive methods english spanish speaking parents year old children viewed multimedia program teaches appropriate discipline strategies intervention play nicely viewed exam room physician visit parents viewed discipline strategies choosing average viewing time min results parents eligible participate completed study black white hispanic least parents racial ethnic group reported program built confidence care child addressed family needs explained things way could understand respected family values sensitive personal beliefs overall parents reported program answered individual questions one parent reported program respect family values conclusions practice discipline education integrated pediatric primary care clinic way family centered culturally sensitive majority parents results implications development implementation population based parenting programs primary prevention child abuse violence
purpose healthcare projects face multiple obstacles achieving sustainability paper aims provide information regarding energy consumption healthcare facilities identify barriers sustainability suggest methods improve effectiveness buildings design methodology approach study investigates sustainability healthcare buildings examining national databases energy use energy savings authors initiate dialogue topic interviewing experts healthcare planning design regarding implications data challenges sustainability potential solutions challenges findings analysis data energy information administration revealed healthcare facilities rank second among building types usa energy use per square foot rank fourth total energy use data green building council showed per cent healthcare buildings registered leadership energy environmental design rating system per cent achieved certification low compared building types research limitations implications research discussion must continue engaging stakeholders interpret data identify transformative solutions facilitate sustainable healthcare design construction operation practical implications important approach sustainability healthcare social economic environmental health related perspectives authors identify five major barriers sustainable healthcare design construction discuss practical solutions originality value given energy demands healthcare buildings facilitating sustainability potential make significant difference national energy use empirical research evidence based design potentially help accelerate sustainability clarifying impacts documenting economic operational returns investment
defined sexually explicit material elicits erotic thoughts feelings behaviours internet pornography prevalent form media may facilitate problematic use craving engagement research suggests superordinate cognitions information processing desire thinking metacognition central activation escalation craving addictive behaviours current study aimed contribute literature testing proposed metacognitive model desire thinking craving sample problematic pornography users revising model incorporating negative affect theoretical perspective environmental cues trigger positive metacognitions desire thinking directly influence desire thinking resulting escalation craving negative metacognitions negative affect participants recruited via online survey screened problematic internet pornography use path analyses used investigate relationships among aforementioned constructs final sample participants consistent previous research results study validated existence metacognitive processes activation desire thinking escalation craving indicating desire thinking potential influence negative affect additionally results supported role significant indirect relationships constructs within revised model metacognition desire thinking psychopathology collectively findings demonstrate clinical value metacognitive conceptualisation problematic pornography use exploring metacognitive mechanisms underpin problematic internet pornography use may give rise development new treatment relapse prevention strategies elsevier ltd rights reserved
paper analyzes basic linear generation algorithm circle generation filling algorithm bezier curve generation algorithm graphics combined achieve algorithm theoretical experimental comparison basic algorithms linear generation paper discusses methods circular regions filling midpoint circle algorithm bresenham algorithm circle equation seed filling algorithm symmetry points algorithm efficiency kinds circle filling algorithm compared experiments according discuss analyze different implementation ways certain guiding significance good students master relevant knowledge improve professional skills
background large scale implementation evidence based psychotherapies ebps cognitive processing therapy cpt posttraumatic stress disorder tremendous impact mental physical health healthcare utilization quality life many mental health systems mhs invested heavily programs implement ebps eligible patients receive ebps routine care settings clinicians appear deliver full treatment protocol many patients emerging evidence suggests cpt ebps delivered low levels fidelity clinical outcomes negatively impacted thus identifying strategies improve sustain delivery cpt ebps critical existing literature suggested two competing strategies promote sustainability one emphasizes fidelity treatment protocol ongoing consultation fidelity monitoring focuses improving fit effectiveness treatments appropriate adaptations treatment clinical setting process data driven continuous quality improvement neither evaluated terms impact sustained implementation methods compare approaches key sustainability outcomes provide initial guidance sustainability strategies propose cluster randomized trial mental health clinics three diverse mhss implemented cpt cohorts clinicians clinical managers participate year fidelity oriented learning collaborative year continuous quality improvement oriented learning collaborative patient level ptsd symptom change cpt fidelity adaptation penetration clinics capacity deliver ebp examined survey interview data also collected investigate multilevel influences success two learning collaborative strategies research conducted team investigators expertise cpt implementation mixed method research strategies quality improvement implementation science input stakeholders participating mhs discussion broad implications supporting ongoing delivery ebps mental health healthcare systems settings resulting products potential significantly improve efforts ensure ongoing high quality implementation consumer access ebps
growth mobile technologies evolutionary progression technology opened revolution computing quicker time frame easy availability extreme mobility rich set applications made smartphones inevitable tool students high time academic domain innovative teaching practices inclusion mobile technologies bridge gap academia industry considerable manner paper aimed introduce innovative approach learning computer programming smartphone platform proposed approach intends introduce new pedagogy teaching programming platform developing applications instead teaching programming language creating applications main premise practice introduction tailored module teach java programming language developing apps leading mobile platform android proposed module appropriate alternative module introduction programming computer science curriculum across globe pilot implementation done one premier higher education centres gulf council country gcc ontology based implementation proposed module ensures consistency delivery future work focus direction published elsevier ltd open access article license
purpose study investigate whether core members social capital associated individually perceived externally evaluated prestige cooperation among hiv aids related civil society organizations csos accomplish cross sectional study using multistage sampling carried eight provinces china data collected core members via questionnaires self evaluated performance respondents evaluated measured interviews conducted core members supervisory staff local centers disease control prevention multivariate logistic regression analysis indicated social support adjusted odds ratio aor organizational commitment aor significantly associated higher odds prestige performance self evaluation furthermore social support aor trust aor organizational commitment aor significantly correlated cooperation performance trust positively associated cooperation performance external evaluation findings may provide new perspective challenges csos face response growing hiv aids epidemic china social capital may increase performance accelerate organizational growth ultimately improving hiv aids prevention care
introduction studies given yet clear answer genetic background suicidal predisposition associations polymorphisms tph httlpr genes violent suicidal behavior revealed least inconsistencies method selected strong candidate genes snps slca acp replication study searched associations precisely described suicidal phenotype affective patients polymorphisms selected neurobiological pathways genes well interactions constitute suicidal risk results results confirm role tph tph hta crhr acp variants risk suicidal behavior limitations study analyzed limited number candidate genes one linked lithium mechanism action data pharmacological treatment investigated patients relation time suicide attempt conclusion results indicate polymorphisms various signaling pathways involved pathogenesis suicidal behavior non genetic factors also involved risk suicidal attempts elsevier rights reserved
frequency compensation multistage operational amplifier amp normally performed solving nodal equations equivalent circuit obtain amp final transfer function process often tedious offers little insight roles selected compensation scheme paper present graphical design approach two stage three stage amps active feedback miller compensation viewing frequency compensation standard feedback problem utilize well known graphical tools root locus bode plot understand effects compensation estimate locations closed loop poles zeros amp intuitive graphical design procedures two stage three stage amps also formulated show effectiveness illustrate design approach design three stage amp standard complementary metal oxide semiconductor cmos process load capacitance post layout simulations show amp achieves low frequency gain phase margin unity gain frequency mhz consuming total bias current supply voltage comparisons published amplifiers show amp achieves figure merits comparable state art copyright john wiley sons ltd
modified international knee documentation committee subjective knee form pedi ikdc widely used patient reported tool ranging scale aimed translate pedi ikdc danish assess reproducibility responsiveness children knee disorders translation complied international guidelines reproducibility assessed children years responding pedi ikdc baseline days analysis responsiveness children years responded pedi ikdc months test retest reliability excellent intraclass correlation coefficient standard error measurement points smallest detectable change sdc points evaluating responsiveness large effect found children reporting improvement compared children reporting deterioration change score correlated external anchor global rating scale consisting answers great deal worse great deal better spearmen rho minimal clinically important changes conclusion excellent test retest reproducibility found group level individual level sdc high pedi ikdc showed adequate responsiveness suitable assessing improvement deterioration children knee disorders
fusarium infection severe fungal infection caused fungi genus fusarium commonly occurs immunocompromised patients malignant hematological comorbidities secondary hematopoietic stem cell transplant classical route contamination inhalation infection may also occur contiguity skin lesion report describes case year old woman developed graft host disease gvhd days receiving allogeneic stem cell transplant sibling donor hodgkin disease day transplant patient presented fever several painful subcutaneous tender red nodules ulcerative necrotic features pelvic region right leg extensive glass infiltrative lesions lungs pansinusitis however patient onychomycosis following skin biopsy culture cutaneous lesions computed tomography scanning lungs scanning magnetic resonance imaging facial sinuses patient diagnosed disseminated fusarium species infection despite intensive treatment voriconazole patient succumbed respiratory insufficiency day transplant case noteworthy patient additional risk associated allogeneic transplant transplant mismatch severe neutropenia prior clinical signs onychomycosis association skin lesions gvhd lesions increased initial immunosuppression delayed diagnosis
paper introduces new concept termed continuous task string consists specific combinations preconstruction planning pcp project execution tasks linked together high probability improving project performance two stage process combinations pcp tasks respectively reduced validated task strings task strings evaluated electrical construction professionals statistically quantify potential influence task strings cost schedule success statistical analysis supported hypothesis task strings viewed important cost schedule success would also viewed critically interdependent hence completion pcp task combination viewed key ingredient project success research reported paper provides strong theoretical foundation studies influence task strings project performance ultimately elucidating relationship preconstruction planning project execution tasks research reported paper help electrical contractors achieve project performance improvement effective task level strategies
simulation models widely used risk analysis study effects uncertainties outcomes interest complex problems often models computationally complex time consuming run latter point may odds time sensitive evaluations may limit number parameters considered article give introductory tutorial focused parallelizing simulation code better leverage modern computing hardware enabling risk analysts better utilize simulation based methods quantifying uncertainty practice article aimed primarily risk analysts use simulation methods yet utilize parallelization decrease computational burden models discussion focused conceptual aspects embarrassingly parallel computer code software considerations two complementary examples shown using languages matlab brief discussion hardware considerations located appendix
multifunctional platform based microhotplate developed applications including pirani vacuum gauge temperature gas sensor consisted tungsten microhotplate chip operational amplifier platform fabricated standard complementary metal oxide semiconductor cmos process tungsten plug standard cmos process specially designed serpentine resistor microhotplate acting heater thermister sacrificial layer technology microhotplate suspended silicon substrate gap chip operational amplifier provided bias current microhotplate platform used develop different kinds sensors first one pirani vacuum gauge ranging second one temperature sensor ranging degrees third one thermal conductivity gas sensor could distinguish gases different thermal conductivities constant gas pressure environment temperature fourth application extra fabrication processes including deposition gas sensitive film platform used metal oxide gas sensor detection gas concentration
study presents automatic generation control unequal four area thermal system appropriate generation rate constraint governor dead band gdb performances several classical controllers single degree freedom proportional integral derivative pid two degree freedom pid dof pid three degree freedom pid dof pid secondary controllers evaluated separately system attempt made apply successful evolutionary optimisation technique named biogeography based optimisation technique simultaneous optimisation several variables controller gains setpoint weights comparison dynamic responses corresponding pid dof pid dof pid reveals dof pid controller outperforms others sensitivity analysis reveals optimum gains parameters optimal controller obtained nominal conditions robust need reset wide changes system condition like system loading system parameters inertia constant synchronising coefficient gdb performance dof pid controller also studied different step load perturbations slps random load perturbations rlps analysis proves dof pid controller performs better dof pid different slps rlps
antisocial personality disorder aspd one whose characteristics high impulsivity great interest field brain structure function however little known possible impairments cortical anatomy aspd terms cortical thickness cth surface area well possible relationship impulsivity neuroimaging study first investigated changes cth aspd patients comparison healthy controls performed correlation analyses measures ability impulse control found aspd patients showed thinner cortex larger several specific brain regions bilateral superior frontal gyrus sfg orbitofrontal triangularis insula cortex precuneus middle frontal gyrus mfg middle temporal gyrus mtg left bank superior temporal sulcus sts addition also found ability impulse control positively correlated cth sfg mfg orbitofrontal cortex ofc pars triangularis superior temporal gyrus stg insula cortex knowledge study first reveal simultaneous changes cth aspd well relationship impulsivity cortical structural changes may introduce uncontrolled callous behavioral characteristic aspd patients potential biomarkers may helpful understanding pathomechanism aspd ibro published elsevier ltd rights reserved
ecological control line system innovation field ecological environment protection china become important strategy national ecological protection ten years passed since first ecological control line shenzhen delimited study examines connotations ecological control line current study status china abroad takes brief description delimitation background existing problems ecological control line shenzhen problem solving strategy gradually transforming extensive management refined management study proposes differential ecological space management model merges space system management system support system implementation paths include following five aspects delimiting ecological bottom lines protect core ecological resources formulating access systems new construction projects strictly control new construction implementing construction land inventory reclamation assisted market means regulating boundary adjusting procedures processes constructing ecological equity products using multiple means implement rights relief finally study illustrates progress implementation discusses rigorousness flexibility problems ecological control line calls promotion legislation management model implementation paths proposed study referential significance developing countries megacities achieve ecological protection sustainable development elsevier ltd rights reserved
objective paper present example matrix functions used solve modern control exercise specifically solution equation state matrix differential equation calculated resolve two different methods presented first using properties matrix functions side using classical method laplace transform
caryophyllata flos clove widely used condiment chinese medicine reportedly helps relieve asthma allergies however underlying mechanisms remain unclear particular mechanism affecting dendritic cells dcs play critical role immune response remains unknown study examine effects caryophyllata flos methanolic extract cfme major compound eugenol functions results showed cfme eugenol significantly inhibited activation maturation ics cfme eugenol approximately respectively cfme eugenol halted cell proliferation contact hypersensitivity responses inhibited mice cosensitized either cfme eugenol demonstrated first time clove major active ingredient eugenol exhibited significant immunosuppressive effect functions revealing clove functional food ameliorate chronic inflammation autoimmunity published elsevier ltd
energy industry striving cost efficient production low emissions efficiency energy conversion processes one important factors affecting path goal paper provides framework monitoring steam boiler operation power stations framework based use historical process data reference real time operation actual boiler efficiency monitored together expected efficiency estimate highest historical efficiency corresponding process state based data driven model presented approach process state defined basis variables strongest correlation boiler efficiency according information theoretic variable ranking boiler performance monitored using statistical process control chart difference expected actual efficiencies framework tested using data circulating fluidised bed boiler corner fired boiler results revealed strongest correlations process variables boiler efficiency substantially consistent cases moreover framework provides novel measure boiler performance enhancement elsevier ltd rights reserved
research collaborative remembering suggests collaboration hampers group memory collaborative inhibition yet enhances later individual memory studies examining collaborative effects memory emotional stimuli scarce especially concerning later individual memory present study female undergraduates watched emotional movie recalled either collaboratively individually followed individual free recall test recognition test replicated standard collaborative inhibition effect line literature collaborative condition displayed better post collaborative individual memory importantly post collaborative free recall centrality information movie plot play important role recognition rendered slightly different results although collaboration rendered correct recognition central details enhance recognition background details secondly collaborative individual conditions differ respect overlap unique correct items free recall yet recognition former collaborators unanimously endorsed correct answers well errors finally extraversion neuroticism social anxiety depressive symptoms moderate influence collaboration memory implications fields forensic clinical psychology discussed
paper improved design high factor cmos active inductor operating mid mhz frequency range introduced analysis equations used gain insight behavior active inductor moreover based equations analysis ways improving quality factor discussed performance improvement based new design coupled use feedback series resistor external capacitor shown analyzed simulation results performance improvement compared contrasted cmos ami process based existing literature cmos active inductors found increasing applications high speed analog signal processing data communications circuits due inability chip spiral inductors scale technology vast range applications includes impedance matching circuits filter circuits oscillators lumped element power dividers
various existing solution solving xor problem artificial neural network even author previous work proposed several solutions problem paper see new solution xor problem author given brief introduction artificial neural network concept discussion linear separablility non linear separability made fixation non linearly separable problem made solution non linearly separable problem xor problem proposed architectural graph signal flow graph proposing final solution problem given mathematical explanation solution given
angioedema rare condition manifests sudden localised non pitting swelling certain body parts including skin mucous membranes vital anaesthesiologists understand condition may present suddenly perioperative period airway compromise identify literature review authors searched pubmed medline embase scopus web science databases english language articles covering year period angioedema either mast cell mediated bradykinin induced older therapies histaminergic symptoms well known anaesthesiologists adrenaline anti histamines steroids whereas older therapies bradykinin induced symptoms include plasma attenuated androgens new classes drugs bradykinin induced symptoms available including anti bradykinin plasma kallikrein inhibitor esterase inhibitors used prophylactically rescue medications anaesthesiologists unique position coordinate perioperative care complex group patients
objective neuromodulation emerged effective therapeutic option treatment oab children however knowledge study yet evaluated results neuromodulation sessionby session basis aim study evaluate rate complete response overactive bladder oab symptoms session transcutaneous electrical stimulation tens protocol sessions therapy method prospective study improvement luts children isolated oab included study children age years complained urinary urgency bell tower shaped uroflowmetry patterns post void residual expected capacity age less patient treated anticholinergic children excluded lower urinary tract symptoms luts secondary urinary tract abnormalities patients underwent parasacral transcutaneous neurostimulation tens development symptoms observed right session using visual analog scale vas means absence improvement represents maximum improvement symptoms results noted complete resolution symptoms urgency urge incontinence frequency holding maneuvers patients starting third session last sessions patients reported complete resolution symptoms complete resolution patients reported symptoms worsened minimum level improvement temporary returned improvement children showed improvement level greater fifth treatment session times likely success last treatment session conclusion found patient experience complete symptom resolution quickly following third session tens complete response rate progressively increases number sessions slowly session rapidly symptom improvement least reported fifth session higher chance patient full resolution symptoms end treatment
recent studies shown patients eating disorder deficits neuropsychological functioning cognitive remediation therapy crt developed improve cognitive deficits objective study apply crt group adolescents eating disorder whose age ranged central coherence cognitive flexibility analyzed means rey complex figure test trail making test clinical measures ten weekly minute sessions designed results study indicated crt outstanding improve central coherence patients eating disorder research needed evaluate efficacy crt clinical population future research may incorporate randomized controlled trials control groups well use transdiagnostic perspective
result low concentration avian influenza viruses samples routine screening separation concentration viruses vital sensitive detection present novel three dimensional printed magnetophoretic system continuous flow separation viruses using aptamer modified magnetic nanoparticles magnetophoretic chip magnetic field fluidic controller magnetic field designed based finite element magnetic simulation developed using neodymium magnets maximum intensity gradient dragging nanoparticle virus complexes magnetophoretic chip designed solidworks fabricated three dimensional printer magnetophoretic channel continuous flow separation viruses using phosphate buffered saline carrier flow fluidic controller developed using microcontroller peristaltic pumps inject carrier flow viruses trajectory virus nanoparticle complexes simulated using comsol optimization carrier flow magnetic field respectively results showed viruses could captured separated concentrated using proposed magnetophoretic system separation efficiency continuous flow separation time min sample volume
seasonal changes photoperiod influence body weight metabolism mice examined effect changes photoperiod expression glucose transporter genes skeletal muscle adipose tissue cbl mice glut expression lower gastrocnemius muscle mice exposed short duration day long duration day accompanying changes glut protein levels although glut expression mouse coleus muscle higher glut protein levels remained unchanged confirm functional significance photoperiod induced changes glut expression checked variations insulin sensitivity blood glucose levels insulin injection remained high suggesting mice exposed showed lower sensitivity insulin exposed also attempted clarify relationship glut expression physical activity mice following changes photoperiod locomotor activity detected via infrared beam sensor lower however facilitated voluntary activity using running wheels rotation wheels similar groups mice although physical activity levels enhanced due running wheels glut expression gastrocnemius muscle remained unchanged thus variations photoperiod altered glut expression mouse skeletal muscle subsequent changes glut protein levels insulin sensitivity effects might independent physical activity elsevier inc rights reserved
author argues media literacy typically overestimates importance theory critique underestimates media production may contribute learning detailed study student violent video author considers informal knowledge evidenced practical work suggests mobilize ways knowing pedagogically
disease specific cytogenetic abnormalities involving bcl gene rearrangement frequently exist cytogenetic abnormalities contributing disease progression follicular lymphoma present study retrospectively investigated prognostic impact bcl unrelated cytogenetic abnormalities consecutively diagnosed patients two independent institutes metaphase spreads tumor cells obtained use banding analysis patients recurrent additional cytogenetic abnormalities included chromosome gains losses associated shorter progression free survival pfs analyzed patients evaluable banding results negative impact evident patients treated using chop like regimen first line treatment contrast predictive shorter pfs patients initially treated chop like regimens without maintenance therapy negative impact evident patients evaluable banding results results suggest presence molecular region chromosome responsible shorter pfs following chop like chemotherapy
bioregenerative life support systems form transparent inflatable greenhouses present economical reliable solution providing consumables astronauts long duration space missions nasa goal place human explorers mars identification cladding materials appropriate optical physical properties withstand high ultraviolet radiation low pressure low temperature martian environment necessary greenhouse design objective study develop methods evaluating effects simulated mars environmental conditions transmissivity mechanical strength candidate greenhouse cladding materials university florida mars simulation chamber utilized expose material samples simulated mars environmental conditions changes control versus exposed material sample transmissivities measured using spectroradiometer range wavelengths material peak yield stresses determined using instron universal testing machine results indicated mars simulated environmental conditions mars equivalent days materials experienced reduction transmission photosynthetically active region decrease material strength short methods developed study provide means evaluating transmissivity strength candidate greenhouse cladding materials mars environmental conditions determination suitability greenhouse design
background countries face significant challenges complex manifestations malnutrition affects one three people globally systematic reviews provide ready use syntheses quality appraised evidence inform decision making actions enhance utility quality future cochrane nutrition evidence described scope quality nutrition systematic reviews cochrane database systematic reviews cdsr methods screened active cdsr records july identify reviews protocols using pre specified eligibility criteria definitions duplicate independent data extraction included criteria inclusion studies completed reviews picos assessed methodological quality amstar use grade mapped reviews global burden disease data categorised paradigm medical lifestyle socio ecological review question analysed results using descriptive statistics results screened records included completed reviews cochrane review groups crgs protocols crgs published crgs reviews completed reviews produced pregnancy childbirth neonatal metabolic endocrine disorders developmental psychosocial learning problems kidney transplant heart crgs reviews searches new studies thereafter supplementation supplement interventions common majority micronutrients followed food interventions reviews included randomised controlled trials included designs used grade median amstar score interquartile range high amstar moderate amstar quality framed questions using medical paradigm top causes years life lost reviews addressed preterm birth diabetes ischaemic heart disease leading risk factors disability adjusted life years targeted childhood undernutrition high body mass index conclusions nutrition reviews comprised active cdsr records widely distributed across nearly crgs reflected double nutrition burden analysis presents comprehensive description scope quality cochrane nutrition reviews identifies gaps future activities support actions address nutrition burden line current nutrition agenda impetus
ptv quantitative flow measurement technique aims track lagrangian paths set particles three dimensions using stereoscopic recording image sequences basic components features constraints optimization tips ptv topology consisting high speed camera four view splitter described discussed article technique applied intermediate flow field circular jet approximate lagrangian flow features turbulence quantities eulerian frame estimated around ten diameters downstream jet origin various radial distances jet core lagrangian properties include trajectory velocity acceleration selected particles well curvature flow path obtained frenet serret equation estimation velocity turbulence fields around jet core axis cross plane located ten diameters downstream jet compared literature power spectrum large scale streamwise velocity motions obtained various radial distances jet core
objectives investigate economic burden running related injuries rri occurred week start run program dutch athletics federation design prospective cohort study methods monetary cost analysis using data prospectively gathered alongside rri registration nlstartrun study rri data collected weekly cost diaries applied two six weeks rri registration collect data regarding healthcare utilisation direct costs absenteeism paid unpaid work indirect costs rri defined running related pain hampered running ability three consecutive training sessions results participants included analysis reported total rris total cost data rris reported participants missing therefore multiple imputation procedure performed economic burden direct plus indirect costs rris estimated sic sic sic per rri sic sic sic per participant direct cost per rri sic sic sic indirect cost per rri sic sic sic indirect cost higher sudden onset rris gradual onset rris mean difference sic sic sic conclusions direct costs rris fold higher indirect costs sudden onset rris presented higher costs gradual onset rris results study important provide information public health agencies policymakers economic burden rris novice runners sports medicine australia published elsevier ltd rights reserved
background stress fractures common overuse injury bone comprising sports injuries resulting pain loss game time consequence repetitive loading forces bone often seen response increase activity training load especially common lower leg athletes involved running jumping sports objectives objective review examine management stress fractures lower leg athletes review discusses pathomechanism etiology management relative rest activity modification use pneumatic leg bracing ultrasound electrical stimulation laser therapy foot orthoses nonsteroidal anti inflammatory drugs nsaids less commonly used approaches surgery review also evaluates specific management individual stress fracture sites major findings stress fractures low risk delayed nonunion relative rest activity modification recommended literature regarding modalities mixed results studies low quality based military populations surgery may necessary stress fractures high risk delayed nonunion respond aggressive nonweight bearing management characteristics specific stress fracture sites need considered throughout rehabilitation conclusions difficult draw conclusions literature regarding many modalities clinically used manage stress fractures research modalities research specific stress fracture sites would useful guide practice
authors present general synthesis method realisation nth order current transfer function using current differencing buffered amplifier easily derived commercially available active component use active component simplifies implementation analogue signal processing filters hence makes proposed circuit attractive elsevier science ltd rights reserved
monitoring various hardware software events energy consumption essential energy management mobile devices however current mobile operating systems lack monitoring functionality provide sufficient information kind paper propose pemos power events monitor mobile operating systems framework power event apis mobile devices provides wide spectrum energy related information enabling depth analysis energy problems pemos provides set well defined apis mobile facility defining various energy related system events power events classified system events application events encompassing extensive fine grained power related events benefits pemos include extensive coverage power events high portability across various platforms efficient api implementation framework structure portable across multiple devices standard ioctl based api implementation enables operations different devices without system modification implemented pemos android platform evaluate efficacy usefulness experimental results case studies confirm pemos effective useful range energy management systems minimal overhead elsevier rights reserved
paper presents mechanical chemical environmental degradation induced recycled construction demolition wastes short term tensile behaviour nonwoven polypropylene geotextile reinforced polyester pet yarns order study chemical environmental degradation damage trial embankment plant constructed using recycled filling material damage caused mechanical actions installation also simulated installation damage laboratory tests wide width tensile tests performed geotextile samples exhumed trial embankment months laboratory damaged samples intact received samples short term tensile behaviour compared scanning electron microscope sem images intact exhumed specimens also presented
acquisition information person affect liking person recent set studies suggests liking decreases people acquire information norton frost ariely test less hypothesis along alternative hypothesis based information integration theory according alternative people average available person information unbiased manner liking person described random sample number traits trait universe approximates degree liking would obtained trait information known correlation liking number traits zero present results computer simulation empirical person judgment studies using bayesian analyses find evidence consistent information integration hypothesis less hypothesis
report intermediate scale plasma irregularities polar ionosphere inferred high resolution radio occultation measurements using gps global positioning system cassiope cascade smallsat ionospheric polar explorer satellite radio links high inclination cassiope high rate signal reception gps attitude positioning profiling receiver cassiope enable high resolution investigation dynamics polar ionosphere unprecedented detail intermediate scale scintillation producing irregularities correspond scales inferred applying multiscale spectral analysis phase measurements using multiscale spectral analysis approach satellite data polar operational environmental satellites defense meteorological satellite program discovered irregularity scales phase scintillations distinct features auroral oval polar cap found large length scales intense phase scintillations prevalent auroral oval compared polar cap implying irregularity scales phase scintillation characteristics function solar wind magnetospheric forcings
aiming solving problems dynamic occlusion complete denture field dental restoration paper presents computerized system viewpoint integration related disciplines firstly displacement matrix mandibular movement hanau articulator established means method direction cosine matrix spatial mechanism secondly programming matlab language technical computing vtk visualization toolkit adopting techniques laser scanning computer graphics computer database digitized model denture reconstructed coordinate data mark points measured basis digitized model computerized simulation system occlusal contacts complete denture developed aid system dynamic occlusive procedure complete denture mounted hanau articulator clearly observed required angle location views addition posit ions occlusal contacts obtained therefore study helpful research dynamic occlusion complete denture improve dental restorative procedures
dalvik virtual machine integral component used execute applications android one leading operating systems mobile devices dalvik interpreter equipped trace based time compiler enhancing execution performance frequently executed paths traces however traces generated dalvik stopped conditional branch method call return means traces usually short lifetime decreasing effectiveness compiler optimizations applied furthermore time compiler applies simple optimizations performance considerations article present traces region framework extends traces regions statically compiles regions native binaries improve execution android applications framework involves three main stages profiling stage run time trace information application extracted compilation stage regions constructed extracted traces statically compiled native binary iii execution stage compiled binary loaded code cache application starts execute experiments performed android tablet demonstrated framework effective improving execution performance applications decreasing size code cache copyright john wiley sons ltd
dishevelled dvl plays crucial role wnt signaling interacting membrane bound receptors downstream molecules pdz domain cxxc one key molecules interacts dvl negatively regulates wnt catenin pathway osteoblast differentiation recently dvl cxxc interaction identified excellent target osteoporosis treatment therefore desirable detailed structural information dvl cxxc interaction although solution structures dvll pdz domain reported high resolution crystal structure would provide detailed sidechain information essential drug development determined first crystal structure dvl pdz domain resolution compared previously reported solution structure dvll pdz domain crystal belonged space group unit cell parameters alpha beta gamma crystal structure dvll pdz shared topology previously reported structure determined nuclear magnetic resonance nmr however crystal structure quite different solution structure secondary structural region ligand binding pocket molecular modeling based nmr ray crystallographic data yielded detailed information dvll cxxc interaction useful designing inhibitors elsevier inc rights reserved
nonsense mediated mrna decay nmd surveillance mechanism ensuring fast decay mrnas harboring premature termination codon ptc quality control mechanism nmd distinguishes ptcs normal termination codons order degrade ptc carrying mrnas nmd connected various cell processes regulate activate specific cell conditions response mutations mis regulations stresses particular cell programs cell processes connections nmd focus review aims illustrate complexity nmd mechanism regulation highlight cellular consequences nmd inhibition
introduction substance use among elderly emerging mental health problem requires modification management approaches systematic literature natural opiates especially among elderly india rather limited materials methods retrospective chart review included elderly subjects aged seeking outpatient treatment tertiary care addiction center north india information pertaining socio demographic profile clinical characteristics treatment seeking extracted records results subjects male mean age years common substance used doda poppy husk mean duration dependence years six subjects used forms apart natural forms opiates common reason initiation opiate use increase work efficiency dependence another substance apart opiate tobacco present seven subjects majority patients never sought treatment previously despite using substance long duration conclusion natural opioid use among elderly distinct profile especially indian setting use sociocultural sanction need research management elderly natural opioid users may pose important clinical challenge future
paper examines impact nonverbal expressions power organizational spokespersons different crisis stages study investigates vocal nonverbal cues express power crises affects perceptions spokespersons results illustrate spokesperson speaks lowered voice pitch expresses power appears competent one raised voice pitch study examines moderating influence crisis stage impact visual nonverbal cues crisis powerful nonverbal behaviors minimize reputational damage increase perceived competence spokesperson aftermath crisis powerless nonverbal behaviors positively affect organizational reputation intermediate effect perceived sincerity spokesperson
mistaken identifications primary cause wrongful convictions though studies examined errors likely occur none specified errors likely affect address oversight arguing type crime committed affects eyewitnesses misidentify study demonstrated people stereotypes perpetrator appearance vary crime committed study showed stereotypes affect identifications stereotype consistent mannerparticipants believed saw target accused stereotypically black crime remembered higher perceived stereotypicality viz afrocentric features participants believed saw target accused stereotypically white crime finding replicated study using different pair crimes studies demonstrate type crime committed systematically affects eyewitnesses mistakenly identify
attraction natural enemies towards herbivore induced plant volatiles well documented phenomenon however majority published studies carried optimal water nutrient regimes one herbivore happens additional levels ecological complexity added presence second herbivore microorganisms abiotic stress interfere plant natural enemy communication communication stable enough withstand disruption additional biotic abiotic factors investigating effects additional levels ecological complexity key understanding stability tritrophic interactions natural ecosystems may aid forecast impact environmental disturbances especially climate change scenarios often associated modifications plant arthropod species distribution increased levels abiotic stress review explores literature natural enemy attraction herbivore induced volatiles besides herbivory plants challenged additional biotic abiotic factors aim review establish impact different biotic abiotic factors plant natural enemy communication highlight critical aspects guide future research efforts
although cognitively impaired frequently included heterogeneous studies problematic sexual behavior epidemiology etiology approach assessment treatment persons dementia intellectual disability distinct general population incidence inappropriate sexual behavior among intellectually disabled however nature tends socially inappropriate violative intent limited sociosexual education large contributor better addressing area offers target prevention treatment thorough clinical assessment problematic sexual behaviors cognitively impaired requires understanding patient internal experience challenging assessment tools validated general population validated population studies assessed treatment approaches specifically among cognitively impaired however research suggest utility habilitative psychotherapeutic pharmacologic approaches validated among general population
research work coupled field finite element model electro active paper energy harvester presented results verified experimentally electro active paper smart form cellulose coated electrodes sides finite element model developed harmonic transient analyses performed using commercial finite element analysis package two aluminum cantilever benders bonded electro active paper tested validate finite element model results displacement voltage generated energy harvester electrode surfaces measured electro active paper energy harvesters excited fundamental resonance frequencies sinusoidal force located free end voltage obtained electro active paper energy harvester finite element model respectively experimental results shown good agreement finite element model direct piezoelectric effect electro active paper shows potential cellulose based eco friendly energy harvester
past years knowledge evidence based psychological interventions pediatric chronic pain dramatically increased overall evidence support psychological interventions pediatric chronic pain strong demonstrating positive psychological behavioral effects variety children range pain conditions however wide scale access effective psychologically based pain management treatments remains challenge many children suffer pain increasing access care reducing persistent biomedical biases inhibit attainment psychological services central focus current pain treatment interventions additionally number evidence based treatments increase tailoring treatments child family particular needs increasingly possible article discuss theoretical frameworks well specific psychological skills strategies currently hold promise effective agents change review summarize trends development well researched outpatient interventions past ten years discuss future directions intervention research pediatric chronic pain
background use biopsies determine kidney health kidney transplantation invasive procedure risk patient consequently noninvasive test transplanted kidney health would provide significant advantage current clinical practice methods urines kidney donors nephrectomy pretransplant patients native kidney disease posttransplant kidney recipients examined protein biomarkers diagnose prognose kidney disease proteins extracted reverse phase affinity analyzed matrix assisted laser desorption ionization time flight mass spectrometry results urine individuals healthy kidneys showed components two ubiquitous saposin glycoisoforms patients kidney disease lacked saposin showed new components two patterns common contained beta microglobulin plus one peaks pattern lacked beta microglobulin contained several degradation products alpha antitrypsin pathologic components included urinary protein transthyretin component conclusions patients acute rejection showed profiles ranged kidney donors advanced kidney disease range patterns may useful analysis transplant patients without complications persons developing kidney disease transplant
background associations obesity incidence heart failure observed causality uncertain hypothesized gastric bypass surgery leads lower incidence heart failure compared intensive lifestyle modification obese people methods included obese people without previous heart failure swedish nationwide registry people treated structured intensive lifestyle program scandinavian obesity surgery registry analyses used inverse probability weights based baseline body mass index propensity score estimated baseline variables treatment groups well balanced terms weight body mass index potential confounders associations treatment heart failure incidence defined national patient register analyzed cox regression results gastric bypass surgery patients average lost weight year years lifestyle modification patients median years surgery patients lower heart failure incidence lifestyle modification patients hazard ratio confidence interval achieved weight loss year related hazard ratio heart failure confidence interval treatment groups combined results robust sensitivity analyses conclusions gastric bypass surgery associated approximately one half incidence heart failure compared intensive lifestyle modification study large nationwide registries also observed graded association increasing weight loss decreasing risk heart failure
long term goal artificial intelligence make machines learn think like human beings due high levels uncertainty vulnerability human life open ended nature problems humans facing matter intelligent machines unable completely replace humans therefore necessary introduce human cognitive capabilities human like cognitive models systems develop new form hybrid augmented intelligence form machine intelligence feasible important developing model hybrid augmented intelligence divided two basic models one human loop augmented intelligence human computer collaboration cognitive computing based augmented intelligence cognitive model embedded machine learning system survey describes basic framework human computer collaborative hybrid augmented intelligence basic elements hybrid augmented intelligence based cognitive computing elements include intuitive reasoning causal models evolution memory knowledge especially role basic principles intuitive reasoning complex problem solving cognitive learning framework visual scene understanding based memory reasoning several typical applications hybrid augmented intelligence related fields given
input output stability theory indispensable tool control engineering however classic results conic sector theorem applied important cases technical note extends original conic sector theorem apply open loop unstable systems negative upper conic bounds incorporates careful treatment degenerate conic systems alterations accounting nonzero initial conditions simulations highlight contributions facilitate robust control challenging circumstances
brief presents two original implementations improved accuracy current mode multiplier divider circuits besides advantage simplicity original multiplier divider structures present advantage small linearity errors obtained result proposed design techniques respectively extended range input currents original multiplier divider circuits permit facile reconfiguration presented structures representing functional basis implementing complex function synthesizer circuits proposed computational structures designed implementing cmos technology low voltage operation supply voltage circuits power consumptions respectively frequency bandwidths mhz respectively
novel dynamic ligament smart material exhibits strongly rate dependent response extension developed characterized devices based elastomeric polymers shear thickening fluids exhibit low resistance extension rates stretched higher resist higher force link shear thickening fluid rheology dynamic ligament tensile performance presented explain rate dependent response future recommendations improving device performance presented along host different potential application areas including safety equipment adaptive braces sporting goods military equipment
background adolescents early young adults ayas cancer high risk poor outcomes positive psychological responses benefit finding may buffer negative impacts cancer poorly understood population objective aimed prospectively describe content trajectory benefit burden finding among ayas develop potential targets future intervention patients methods one one semistructured interviews conducted english speaking aya patients aged years within days diagnosis noncentral nervous system malignancy requiring chemotherapy months later interviews coded using directed content analyses priori schema defined existing theoretical frameworks including changed sense self relationships philosophy life physical well compared content raw counts ratios benefit burden patient time point setting subjects seventeen participants one tertiary academic medical center mean age years sarcoma acute leukemia lymphoma completed interviews hours transcript data results average benefit counts higher average burden counts time point interviews benefit burden ratio positive changed sense self common benefit across time points reported benefits reports physical distress common burden longitudinal analyses suggested perceptions evolved participants tended focus less physical manifestations personal strengths life purpose conclusions ayas cancer identify benefits burdens throughout cancer treatment demonstrate rapid maturation perspectives findings inform communication practices ayas also suggest opportunities interventions potentially improve outcomes
quantum computing synthesis reversible circuits important topic reversible circuit synthesis particularly challenging complexity grows number bits increases date many reversible circuit synthesis algorithms proposed unable find optima within acceptable time traditional methods consider partial interests resulting cost would gates paper proposes novel method called bound oriented algorithm ability find optimal solution high hit rate one greater average moreover prediction optima bound reduce excess calculation improve efficiency addition special library containing toffoli gates used simplifies algorithm design easily converted common library experiment result shows proposed method performs better methods terms solution quality time cost
introduction gesture integrally linked language cognitive systems recent years seen growing attention movements patients schizophrenia date however investigations gesture youth ultra high risk uhr psychosis examining gesture uhr individuals may help elucidate widely recognized communicative cognitive deficits population yield new clues treatment development method study mismatch indicating semantic incongruency content speech given gesture retrieval used pauses speech person appears searching word idea gestures evaluated uhr individuals matched healthy controls cognitive functions relevant gesture production speed visual information processing verbal production well positive negative symptomatologies assessed results although overall frequency cases exhibiting behaviors low uhr individuals produced substantially mismatch retrieval gestures controls uhr group also exhibited significantly poorer verbal production performance compared controls patient group mismatch gestures associated poorer visual processing speed elevated negative symptoms retrieval gestures associated higher speed visual information processing verbal production symptoms conclusions taken together findings indicate gesture abnormalities present individuals high risk psychosis mismatch gestures may closely related disease processes retrieval gestures may employed compensatory mechanism elsevier rights reserved
synthetic glucocorticoids gcs widely used variety dosages treatment premature infants chronic lung disease respiratory distress syndrome allergies asthma inflammatory autoimmune conditions yet adverse effects glucocorticoid induced osteoporosis growth retardation recognized conversely oxoglutarate precursor glutamine glutamate collagen amino acids exerts protective effects bone development aim elucidate effect dietary administered bone loss caused neonatal treatment clinically relevant maximal therapeutic dexamethasone dex dose long bones neonatal female piglets receiving dex dex untreated examined measurements mechanical properties density mineralization geometry histomorphometry histology selected hormones bone turnover growth markers also analyzed neonatal administration clinically relevant maximal dose dex alone led decrease bone mass ultimate strength length femur humerus respectively geometrical parameters decreased compared control dex impaired bone growth caused hormonal imbalance dietary prevented dex influence vast majority assessed bone parameters restored almost control level piglets receiving heavier denser stronger bones higher levels growth hormone osteocalcin concentration preserved microarchitecture trabecular bone compared dex group administered postnatally potential maintain bone structure animals simultaneously treated maximal therapeutic doses dex opinion may open new opportunity developing combined treatment children treated gcs impact statement present study showed first time dietary oxoglutarate administered postnatally potential improve maintain bone structure animals simultaneously treated maximal therapeutic doses dexamethasone dex may open new direction searching developing combined treatment children treated glucocorticoids gcs since growing group children exposed synthetic gcs adverse effects glucocorticoid induced osteoporosis growth retardation recognized currently proposed combined therapies numerous side effects thus study proposed new direction combined therapies utilizing dietary supplementation glutamine derivative impairment caused dex presented long bones animal model prevented dietary supplementation vast majority assessed bone parameters restored almost control level results support previous thesis regulatory mechanism nutrient utilization regulated glutamine derivatives enrich nutritional science
patient reported outcome measures proms standardized validated questionnaires intended completion patients order measure perceptions health condition treatment without interpretation patient response clinician anyone else mayo clinic score mcs crohn disease activity index cdai frequently used end points conventional clinical trials composite instruments fully objective capture impact disease patient perspective difficult apply routine clinical practice complex time consuming european medicines agency food drug administration evaluating composite indices clinical trials product development guidelines ultimate goal support labelling claims improve safety effectiveness medical products proms allied objective measure inflammation happens informally clinical practice proms developed validated according rigorous criteria set become primary end point clinical trials therapy together objective measure inflammation affect future trials design results find place routine care proms easy use acceptable patients healthcare teams able demonstrate added value normal practice supporting decision making level individual patients ideally proms used clinical trials practice avoid current disconnect interpreting results clinical trials translating routine clinical practice
objectives injuries leading cause pediatric morbidity mortality united states interaction child parent environmental factors may contribute injuries study investigates association coping parenthood injuries children age years methods cross sectional observational study analyzed data national survey children health random digit dialing nationally representative telephone survey information obtained caregiver children years age younger parental coping demands parenthood categorized three groups well somewhat well well well injury defined caregiver report injury within previous months required medical attention results study included surveys children years age younger weighted analysis children reported injury caregivers reported coping parenthood somewhat well reported coping well well adjusted odds ratio sustaining injury children parents reported coping somewhat well demands parenthood compared parents coping well conclusions parental report coping parenthood less well associated injury children ages years highlighting importance interaction parent factors childhood injury
performances mesoporous materials removal polycyclic aromatic hydrocarbons pahs hot gases evaluated systematically adsorption desorption natures pahs different aromatic rings naphthalene nap phenanthrene phe pyrene pyr mesosilicas mcm sba mesocarbon cmk studied adsorption equilibria well described langmuir freundlich model giving order adsorption capacity cmk sba mcm pry phe nap temperature programmed desorption exhibited order ease desorption sba mcm cmk along desorption kinetic triplet determined combined model fitting analysis johnson mehl avrami jma rate equation found well describe pah desorption kinetics except phe sba pyr cmk due potential blockage strong binding respectively mcm simple mesoporous structure provided smooth diffusion consistent behavior low adsorption capacity pah sba micropores small mesopores interconnectivity primary mesopores showed high sorption capacities also diffusion advantages desorption cmk great microporosity facilitated adsorption low concentrations due micropore filling surface hydrophobicity rendered high affinities especially bulkier pyr
ability accurately predict traffic loading essential cost effective bridge maintenance repair programs traffic load model currently used united states design long span bridges developed three decades ago meantime vehicle characteristics traffic patterns changed eurocode traffic loading recent calibrated bridges long work weigh motion traffic records different sites across alabama used establish congested traffic loading traffic microsimulation used generate congestion based real traffic data influence lines two typical long span bridges one cable stayed bridge one suspension bridge determined using finite element models used microsimulation model estimate bridge load effects caused congested traffic results extrapolated find characteristic lifetime maximum values used evaluate eurocode load model assess suitability long span bridges similar way current american load model long span bridges commonly known asce model evaluated see accurately reflects congested traffic loading currently found american highways recent research suggested use aashto load model estimate effects traffic loading long span bridges model also evaluated work
paper proposes new topology variable flux pole changing permanent magnet memory machine fractional slot concentrated windings employed stator side increase utilization ratio winding different pole modes neodymium iron boron poles aluminum nickel cobalt alnico poles hybridized rotor side proposed machine features capability pole number switch back forth six poles two poles changing magnetization directions alnico pms via stator winding besides air gap flux flexibly adjusted varying amplitudes magnetization current pulses topology design principle machine described detail electromagnetic characteristics including magnetic field distributions air gap flux density well back electromotive force emf different operation modes computed using finite element method due existence fifth harmonic component back emf torque quality improved injecting fifth harmonic current different magnetized levels alnico pms besides field regulation capabilities pole modes analyzed
hashimoto thyroiditis common autoimmune disease genistein isoflavone immunomodulatory functions various diseases double blind randomized placebo controlled clinical study investigated effects genistein patients total patients recruited genistein treated patients significant increased levels well reduction serum tsh tpoab tgab levels compared receiving placebo furthermore related cytokine ifn gamma changes genistein treatment suggest immune modulating effect genistein mediated regulating function thl cells overall genistein administration effective well tolerated patients results demonstrate immunological effect genistein patients studies warranted determine longer term effects possible chemopreventive effects thyroid cancer patients elsevier gmbh rights reserved
novice programmers exhibit repertoire affective states time learning computer programming modeling frustration important informs need pedagogical intervention student may otherwise lose confidence interest learning paper contextual keystroke features students within java tutoring system used detect frustration student within programming exercise session compared psychological sensors used studies use contextual keystroke logs less obtrusive equipment used keyboard ubiquitous learning environment technique logistic regression lasso regularization utilized modeling prevent fitting results showed model uses contextual keystroke features achieved prediction accuracy level recall measure thus conclude possible detect frustration student distilling contextual keystroke logs within tutoring system adequate level accuracy
recently two dimensional layered materials drawn much attention due unique atomic electronic properties among layered materials transition metal dichalcogenides tmds display metallic semiconducting properties depending structural phase particular mos one tmd stable structure trigonal prismatic phase sizable band gap utilize semiconducting property take advantage nature metal mos contacts many efforts made employ mos electronic devices field effect transistors despite various studies metal mos contacts however understanding contact behavior ferromagnetic metals mos insufficient additionally need understand contact nature metals various tmds various applications report ferromagnetic contacts mox first principles calculations particular study different electronic spin properties mox interfaces depending type chalcogen atoms calculations show fermi level simply aligned work function difference mox representing fermi level pinning occurring metal semiconductor interfaces schottky barrier types varied depending mox interestingly spin splitting occurs conduction band offset valence band offset depending type mox spin magnetic moment induced mox due ferromagnetic nature
critical step metastases formation cancer cell invasion tissue invasion cells change morphology apply forces surroundings previously shown single metastatic breast cancer cells mechanically indent synthetic impenetrable polyacrylamide gel physiological stiffness attempted invasion benign breast cells indent gels solid tumors breast cancers metastases occur predominantly collective cell invasion thus evaluate effects cell proximity mechanical invasiveness specifically changes gel indention gel indentation induced cells respectively adjacent high metastatic potential low benign breast cells double amounts observed single well separated cells single cells exhibited distribution indentation depths adjacent cells also showed second peak deeper indentations second peak included indenting high cells compared low cells illustrating difference invasiveness thus proximity metastatic cells enhances mechanical ability invade demonstrating collective cancer cell migration likely efficient could potentially provide rapid quantitative approach identify metastatic cells determine metastatic potential
years substituted iron nitrides studied various types approaches physical chemical materials engineering experimental theoretical recently substituted iron nitrides studied theoretical models calculation electronic structure presenting advantage economically viable properties compounds potential application recording material also areas resistance corrosion wear changes occurred alloys transformed nitrides still require studies thus electronic magnetic structure irfe irfe alloys changes caused ground state properties nitrogen atoms included stoichiometry turning substituted iron nitrides type irfen irfen investigated study electronic structure compounds modeled using linearized augmented plane waves lapw augmented plane wave apw method slater modification following methodology used study cohesive energy steady state calculated ground state properties charge transfer magnetic moment hyperfine properties density states obtained ground state properties also assessed pressure variation experienced compounds way induced changes alloys caused introducing nitrogen atom obtained study may assist obtaining new better nitrides
automatic voltage regulator avr equipment maintaining terminal voltage generators specific level time load conditions many controllers avr system designed based linearized normal model avr system robust enough uncertainties parameter variation load change system paper gray pid gpid controller designed avr system gpid controller consists two parts conventional pid controller together gray compensation controller gpid controller gray model used estimate uncertainties online gray compensation controller constructed according estimation results eliminate effect uncertainties improve performance gpid controller parameters optimized new evolutionary algorithm imperialist competitive algorithm ica proposed gpid controller effectively deal uncertainties avr system simulation results illustrate effectiveness proposed control scheme
work product designers evolve phase improvements made technology changes regulations work different aspects product technological legal environmental occupational safety implications european directive promulgates safe machine design principles prevent professional risks principles guide machine designers reduce residual risks much technological state art permits special machine designers definition confronted lack specific standards relating priori risk analysis aim paper present original approach help identify hazards upstream also throughout design process approach based fact hazards linked presence energies hazard identification done detection parameters linked energy sources flows approach feeds back information designers potential contacts energies workers highlight need add preventive measures use functional structural model used represent machine energy architecture different steps lifecycle thus possible identify every interface energies circulate interfaces defined two kinds parameter energetic parameters linked energy properties design parameters paper first presents detailed classification energetic parameters also indicators hazards present machine present logical rules processing energetic parameters others order increase accuracy hazard identification performed conclude results obtained using approach industrial design supply line detailed validate pertinence application earliest design stages improved accuracy subsequent design stages authors published elsevier
effective communication health care benefits patients medical veterinary schools responsibility teach communication skills american veterinary medical association avma council education coe requires communication taught accredited colleges veterinary medicine however best strategy designing communications curriculum unclear calgary cambridge guide ccg one many models developed human medicine evidence based approach structuring clinical consultation communication skills model revised radford use veterinary curricula however best approach veterinary educators teach communication remains determined qualitative study investigated one adaptation ccg currently taught midwestern university college veterinary medicine mwu cvm fulfills client expectations constitutes clinically effective communication two focus groups cat owners dog owners conducted total participants identify common themes veterinary communication participants compared communication skills valued taught mwu cvm results indicated ccg skills mwu cvm adopted applicable cat dog owners comprehensive participants expressed need expand skillset include compassionate transparency unconditional positive regard participants also expressed different communication needs attributed species companion animal owned
approach slabs serve transitional system approach road bridge settlement bridge approach slabs supporting backfill reported ten departments transportation throughout united states according current wyoming department transportation inspection reports bridge approach slab settlements occurred existing bridges also newly built bridges recently opened traffic settlements typically create voids ranging base approach slab geotextile reinforced backfill research presents factors causing bridge approach slab settlements provides appropriate design construction recommendations comprehensive literature review pertaining approach slabs performed examine outcomes research conducted states current specifications standards bridge approach slabs corresponding states departments transportation also evaluated nationwide survey conducted fill missing knowledge identified literature review results survey categorized three groups based percentage bridges experiencing approach slab settlements state results survey show total states satisfied current approach slab designs survey results revealed common cause approach slab settlement poor construction practices important finding survey performing situ tests control backfill compaction reduces amount approach slab settlement using lessons learned literature results survey recommendations developed transportation agencies nationwide elsevier ltd rights reserved
effects tissue type harvest maturity genetic factors expression genes related citrus fruit allergies remain poorly understood present study multiplex real time pcr assay developed monitor expression citrus allergen genes individually advantages much fewer sample requirements simultaneously multiple target genes detection gene specific primer pairs taqman probes three citrus allergen genes cit cit cit house keeping gene beta actin designed based gene sequence differences pcr results showed differential expression patterns found ripening process expression levels cit much higher cit cit peel pulp tissues among citrus cultivars data suggested kao phuang pummelo could safely consumed potential low risk allergenicity considering assessing allergenicity one tests food safety assay might also facilitate breeding production allergy friendly citrus fruits
reference architecture supporting secure big data analytics cloud enabled relational databases based previous attribute order preserving free sfs aopf sfs algorithm proposed paper architecture skyline operator acts baseline component building secure big data analytics smoothly algebra like manner provide general concepts functionalities architecture along future research directions secure big data analytics research
optimization isolation system involves trade isolation efficiency isolator displacement ensure optimal performance quite often latter aspect overruled even though large isolator displacements known linked adverse consequences class smart material referred shape memory alloy sma recently proposed supplement conventional isolation bearings shown facilitate trade owing superelastic property recent usage sma supplementing rubber bearing isolate highway bridge notable presently sma employed conjunction lead rubber bearing lrb referred sma lrb isolating multi storied building frame demonstrated sma lrb largely reduces isolator displacement little sacrifice isolation efficiency compared conventional lrb nonlinear random vibration analysis conjunction stochastic linearization sma behavior demonstrate optimal combination sma lrb characteristics strengths essential ensure performance includes minimizing isolator displacement well maximizing isolation efficiency dealt framework objective optimization robustness optimal design verified parametric studies concerning anticipated variations system parameters seismic loading elsevier ltd rights reserved
herein present fully integrated electronic product code epc gen compatible battery assisted passive bap radio frequency identification sensor tag integrated circuit efficient power management key components tag include adaptive radio frequency energy harvester battery access controller bac storage capacitor charger power gated sensor block external energy efficiently harvested using dynamically controlled rectifying stages threshold compensation technique bac tightly controls power path cutting leakage current battery power gated sensor block supports multiplexed sensing operations power efficient manner sensor interface includes chopper amplifier programmable gain amplifier multiplexers bit adc sensing data logging custom designed nonvolatile memory employed via one time programmable memory digital control block based epcglobal gen standard modified support sensing operation tag chip fabricated poly metal standard standard cmos process tag consumes leakage active operation duty estimated lifespan bap tag year
individuals growth mindset believe failures opportunities baseline intelligence talent used continuous improvement individuals fixed mindset believe baseline intelligence talent developed growth mindset associated greater academic success greater resilience face failure stress second year veterinary students completed three surveys determine mindset perceived levels stress life change score students strong growth mindset growth mindset fixed ideas students strong fixed mindset mindset correlated gpa perceived stress level colleges veterinary medicine assist students providing resources training stress management including training develop growth mindset
glucocorticoids play diverse roles almost physiological systems body including anti inflammatory immunosuppressive roles synthetic glucocorticoids one widely prescribed drugs used treatment conditions autoimmune diseases allergies ocular disorders certain types cancers interest investigating glucocorticoid actions cornea eye established multiple cell types mouse corneas express functional glucocorticoid receptor corneal epithelial cells robust expression define glucocorticoid actions cell type specific manner employed immortalized human corneal epithelial hce cell line define glucocorticoid transcriptome elucidated functions corneal epithelial cells genes significantly regulated within dexamethasone treatment genes associated cell movement cytoskeletal remodeling permeability highly regulated real time vitro wound healing assays revealed glucocorticoids delay wound healing attenuating cell migration functional alterations associated cytoskeletal remodeling wounded edge scratch wounded monolayer however glucocorticoid treatment improved organization tight junction proteins enhanced epithelial barrier function results demonstrate glucocorticoids profoundly alter corneal epithelial gene expression many changes likely impact wound healing epithelial cell barrier function published elsevier ltd
objectives disparities exist rates overweight obesity latino non latino populations attention given risk factors may modifiable interventions involving parent child current study sought identify ethnic differences parental health beliefs relation children health behaviors methods latina non latina mothers rural urban clinics health departments completed self report questionnaires key information included beliefs barriers benefits health practices children health behaviors results children latina mothers consumed significantly soda fried foods exercised less children non latina mothers latina mothers significantly likely perceive barriers healthy eating significantly less likely perceive benefits healthy eating physical activity non latina mothers ethnicity mediated relationship maternal views health benefits soda consumption conclusions policy changes needed promote health education increase accessibility healthy foods safe places exercise latino families
aimsto investigate effects combined therapy anticholinergic agent adrenoceptor agonist bladder dysfunction proliferation related molecule expression rats spinal cord injury sci methodsthe spinal cord transected level female sprague dawley rats divided four groups vehicle day oxybutynin day mirabegron combined administration oxybutynin mirabegron drugs administered oral gavage weeks spinal cord transection evaluated urodynamic parameters bladder tissue remodeling factors resultsnon voiding contractions nvcs storage phase cystometrograms tended decreased three treated groups significant reduction group versus bladder compliance improved intercontraction intervals voided volume bladder capacity increased group three treated groups expression hif tgf decreased compared group expression collagen iii bfgf decreased groups total bladder elastin level increased group conclusionsthe combination therapy anticholinergic agent adrenoceptor agonist elevated bladder elastin level reduced nvcs increased bladder compliance effectively monotherapy sci rats thus combination therapy could effective treatment neurogenic bladder dysfunction including bladder remodeling neurourol urodynam wiley periodicals inc
aimsthe lack validated detrusor overactivity severity tool limits clinical value urodynamics management patients overactive bladder syndrome oab aim study identify urodynamic variables correlate validated oab severity measures methodsthis cross sectional study enrolling consecutive women idiopathic urgency episodes score incontinence impact domain king health questionnaire khq used assess severity oab resultsthe study enrolled women idiopathic cystometric capacity compliance threshold volume first involuntary detrusor contraction idc showed statistically significant negative correlation domain khq urgency episodes statistically significant positive correlation amplitude first idc oab severity measures borderline amplitude highest idc statistically significant differences women without leakage per urethram detrusor contraction conclusionscystometric capacity compliance measured threshold volume amplitude first idc could routinely documented everyday clinical practice measures commonly used describing severity leakage per urethram detrusor contraction amplitude highest detrusor contraction limited role confirming complicated interaction detrusor muscle urethral sphincter pelvic floor women neurourol urodynam wiley periodicals inc
commercial silicon powders nitrided constant temperatures ray diffraction results show small amounts sin sino formed nitridation products samples fibroid short columnar sin detected samples formation mechanisms sin sino analyzed initial stage silicon powder nitridation outside sample captures slight amount atmosphere forming thin film sio surface seals residual silicon inside oxygen partial pressure sio film free silicon decreasing gradually passive oxidation transforms active oxidation metastable sio produced sio partial pressure high enough sio film crack infiltrated central section sample cracks generating sino short columnar sin situ time metastable sio reacts form fibroid sin regions oxygen partial pressure high sin oxidized sino elsevier masson sas rights reserved
study climate related aspects power system operation large volumes wind generation data sufficiently wide temporal spatial scope required relative youth wind industry means long term data real systems available detailed aggregated wind power generation model developed republic ireland using merra reanalysis wind speed data verified measured wind production data period model successful representing aggregate power output middle years period total installed capacity reached around variability scales greater captured well model one additional higher resolution wind dataset found improve representation higher frequency variability finally model used hindcast hypothetical aggregate wind production year period based existing installed wind capacity relationship found several production characteristics including capacity factor ramping persistence two large scale atmospheric patterns north atlantic oscillation east atlantic pattern elsevier ltd rights reserved
new method based modified self organizing maps presented reconstruction deep ocean current velocities surface information provided satellites method takes advantage local correlations data space improve accuracy reconstructed deep velocities assumptions regarding structure water column underlying dynamics flow field made using satellite observations surface velocity sea surface height sea surface temperature well observations deep current velocity autonomous argo floats train map able reconstruct realistic high resolution velocity fields depth validation reveals promising results speed root mean squared error similar factor two smaller competing methods direction errors consistently smaller degrees finally discuss merits shortcomings methodology
paper proposes methodology casting forecasting inflation using data sampling frequency higher monthly data modeled trading day frequency factor model missing observations state space representation estimation adopt methodology proposed banbura modugno contrast existing approaches methodology used paper advantage modeling data within single unified framework allows one disentangle model based news data release subsequently assess impact forecast revision results show inclusion high frequency data energy raw material prices data set contributes considerably gradual improvement model performance long data sources included data set inclusion financial variables make considerable improvement casting accuracy international institute forecasters published elsevier rights reserved
hydromechanical systems prone significant oscillations due ability hydraulic oil store potential energy extremely important considering mobile hydraulic machinery especially machines handle large loads oscillations negatively affect stability payload comfort operator overall safety system particular case earthmoving machines several systems designed order alleviate oscillations increase machine operability systems include passive active designs attempt utilize motion payload way cancel effect machine vibrations paper seeks assess potential advantages active oscillation control strategies respect current state art passive strategies reference case vehicle wheel loader presented analyzed order determine typical vibrational behavior simulation model reference machine developed used assessing machine performance effectiveness current passive vibration damping approach respect reducing vibrations perceived operator cabin well affecting payload presented active electrohydraulic control structure presented using acceleration pressure feedback including adaptive controller constructed using extremum seeking algorithm quantitatively compare relative performances various systems appropriate objective function defined simulation results presented considered control strategies performances compared simulation indicates performance active vibration control systems roughly equivalent currently implemented passive control strategies cases active control performance actually two three times effective passive control authors published elsevier ltd
construction roads soft soils often associated design construction difficulties due compressibility nature weak strength road pavements areas subjected traffic loading static dynamic nature experience rapid deterioration base material progressive permanent surface deformation reduce serviceability subsequently design life pavement study reinforcement geosynthetics geogrids geotextiles used reinforcement inclusions within granular base underlying soft subgrade california bearing ratio less steel test box bench scale plate load tests static cyclic conducted diameter circular steel plate two layer system using universal compression machine static loading applied rate min dynamic sinusoidal load superimposed atop static hold force dynamic load linearly increased incremental load every cycles frequency tests settlement failure composite system considered deformation prescribed unpaved roads results showed significant improvement bearing capacity reduction settlement accruing geosynthetic inclusion shown bearing capacity ratio bcr geogrid geotextile geogrid geotextile combinations respectively additionally settlement reduction factor srf geogrid geotextile geogrid geotextile combination resulted also improvement extended pavement life depicted traffic benefit ratio tbr greater reinforced base layers comparing geotextile geogrid reinforced pavements results showed geosynthetic tensile strength governing performance indicator
back ground ventral tegmental area vta containingmesolimbic andmesocortical dopaminergic neurons implicated processes involving reward addiction reinforcement learning associated variety neuropsychiatric disorders electrical stimulation vta medial forebrain bundle projection target nucleus accumbens nac reported improve depressive symptoms patients affected severe treatment resistant major depressive disorder mdd depressive like symptoms animal models depression sought determine neuromodulatory effects vta deep brain stimulation dbs normal large animal model swine combining neurochemical measurements functional magnetic resonance imaging fmri methods animals swine implanted unilateral dbs electrode targeting vta stimulation frequency pulse width amplitude fmri performed following fmri fast scan cyclic voltammetry combination carbon fiber microelectrodes performed quantify vta dbs evoked dopamine release ipsilateral nac subset swine blood oxygen level dependent bold percent change evoked stimulation performed increasing voltages results significant increase vta dbs evoked bold signal found following regions ipsilateral dorsolateral prefrontal cortex anterior posterior cingulate insula premotor cortex primary somatosensory cortex striatum decrease bold signal also observed contralateral parahippocampal cortex dorsolateral anterior prefrontal cortex insula inferior temporal gyrus primary somatosensory cortex bonferroni corrected neurochemical measurements stimulation time locked changes dopamine release recorded nac confirming mesolimbic dopaminergic neurons stimulated dbs parametric study bold signal changes positively correlated stimulation amplitude conclusions study modulation neural circuitry associated vta dbs characterized large animal findings suggest vta dbs could affect activity neural systems brain regions implicated reward mood regulation pathophysiology mdd addition showed combination fmri electrochemically based neurochemical detection platform effective investigative tool elucidating circuitry involved vta dbs
conducted person survey new york city nyc pharmacies assess availability accessibility price counter rapid hiv self test kit nyc pharmacies stratified high moderate low morbidity neighborhoods hiv diagnosis rate neighborhood pharmacy located random sample pharmacies taken high morbidity neighborhoods highmn low morbidity neighborhoods lowmn pharmacies excluded closed survey non retail min walk subway project staff visited pharmacies determine kit availability pharmacy day survey accessibility locked behind counter price marked shelf product pharmacies lowmn highmn kits available accessible difference neighborhood kits often kept behind pharmacy counter common highmn lowmn kits kept solely behind pharmacy counter median price without variability across neighborhoods rapid hiv self test limited availability access retail pharmacies high median price measured suggests cost remained barrier
dysregulated rest activity rhythm rar patterns associated several health conditions older adults study showed later acrophase associated modestly greater risk falls fractures elderly men associations dysregulated rar patterns osteoporosis risk warrant investigation purpose study investigate relationship rest activity rhythm rar patterns risk falls fractures older men hypothesized dysregulated rar would associated incident falls fractures used wrist worn actigraphy measure rar periods men years enrolled multicenter outcomes sleep disorders men mros sleep study men contacted every months report occurrence falls fractures rar parameters included amplitude difference peak nadir activity counts minute mesor activity counts minute acrophase time day peak activity pseudo statistic rhythm robustness evaluated continuous variables associations reported per increase decrease models adjusted confounders logistic regression used estimate likelihood odds ratio recurrent falls year visit proportional hazards models used estimate risk hazard ratio fractures one year visit men recurrent falls later acrophase associated modestly greater likelihood falls years years complete follow men major osteoporotic fracture clinical spine fracture hip fracture consistent significant associations observed rar patterns fractures later acrophase associated modestly greater risk falls association translate higher fracture risk cohort elderly men
construction industry diverse fast paced enormous division economy directly indirectly causes considerable amount annual environmental damage timber material high demand plays major role construction industry fact leads world soft wood consumption production timber currently takes years soft hard woods reach harvesting age result time frame humans consuming timber faster renewed due rapid expansion cities suburban growth agricultural forestry land becoming valuable remain limits growth pressures one solution problem alternative construction material sustainable grown rapidly manufactured locally bamboo many positive construction properties high flexibility low weight high strength low purchasing cost addition bamboo also many positive sustainable properties including fast growth rate rotated annual harvest ability generate oxygen trees water control barrier qualities ability grow marginal agricultural land capability restore eroded lands qualities bamboo potential assimilate large impact timber construction industry however complete system growing processing using bamboo building material exist paper reports results study focuses possibility bamboo used united states construction industry sustainable cost effective material primarily flooring paper also compares production manufacturing transportation costs benefits bamboo flooring material produced black belt region southeastern united states produced imported asia
objectiverapid eye movement rem sleep behavior disorder rbd commonly associated lewy body disease narcolepsy depression contrast relationship rem sleep without atonia rwa hallmark rbd polysomnography clinical characteristics remains unclear purpose study investigate clinical features psychiatric patients exhibiting rwa relevance lewy body disease methodsof consecutive patients underwent polysomnography psychiatric ward patients sleep apnea syndrome excluded patients exhibiting rwa identified clinical profiles compared groups without rwa resultsthe mean age frequency neurocognitive disorders significantly higher patients rwa without five patients exhibiting rwa episodes dream enactment behavior fulfilled clinical criteria rbd two young patients diagnosed narcolepsy middle aged older patients fulfilled clinical criteria parkinson disease dementia lewy bodies idiopathic rbd major depressive disorder mdd patients mdd exhibited constipation olfactory dysfunction moreover neuroimaging examinations patients mdd revealed isolated occipital hypoperfusion three patients mild dopamine transporter deficit one patient conclusionsrapid eye movement sleep without atonia may associated specific clinical profiles even dream enactment behavior absent continued follow patients mdd exhibiting rwa warranted determine represent prodromal parkinson disease dementia lewy bodies copyright john wiley sons ltd
background previous research revealed clear relationship weight gain persons metabolic diseases developing later studies covered short periods lasting years goal collect decades old often life long anthropometric data correlate figures presence hypertension diabetes methods retrospective international study planned organized compare self recorded data lifelong weight gain among year old patients analyze correlation metabolic diseases developed special attention women weight gain around pregnancy delivery menopause primary care settings germany hungary italy slovakia ukraine results recruited participants men women presented required data diabetics genders highest baseline weight years age weight bmi whole study population increased steadily seventies lesser extent fifties compared control group changes decades greatest among diabetics also greater among patients hypertension weight increase first decades year old men year old women significant risk factor development diabetes among patients diabetes hypertension diagnoses set earlier among single morbidity among females weight increase around pregnancy menopause correlated significantly higher odds diagnoses diabetes hypertension irrespective number children conclusions decade long relationship patients family physicians expected identify higher weight gain patients especially among younger generation intervene necessary
automated home applications ease use technology devices around house electronic devices like shutters entertainment products hifi even wifi constantly standby mode consume considerable amount energy standby mode necessary react commands triggered user time device spends standby mode considered long work present receiver attached home appliances allows devices activated completely turned order reduce energy consumed standby mode receiver contains low power wake module reacts addressable acoustic khz sound signal controls home devices connected acoustic wake signal sent kind speaker available commercial smartphones smartphones operate transmitters signals wake receiver consists two parts low power passive circuit connected wake chip microcontroller active micro electromechanical system mems microphone receives acoustic signal duty cycle required reduce power consumption receiver signal reception occurs microphone active current consumption measured sleep mode active mode average wake range using smartphone sender achieved
active electronically scanned array aesa technology enable next generation radars achieve better jamming resistance capability low probability intercept spreading emissions wide frequency range radars systems consist large number transmit receive modules trms electronically scanned tight time synchronized manner requires digital control move closer radio front end antennas emerging technologies cognitive radars mimo radars continue drive need complex timing synchronization high mix digital measurement requirements meet challenges radar engineers need platform based approach delivers capabilities multi channel phase aligned measurements wide bandwidths high throughput streaming paper discusses fundamentals aesa radars trends radar systems analyzes impact trends test system architecture explains advances pxi modular instrumentation meet challenging requirements
bone mass decreases along aging especially women menopause lower estrogen secretion together low calcium intake study conducted study effect eggshell calcium supplementation bone mass postmenopausal vietnamese women living farming area hanoi vietnam sets subjects matched age bone mass bmi calcium intake divided randomly groups subjects group eggshell calcium group administered calcium eggshell calcium carbonate group calcium calcium carbonate placebo group received calcium supplementation bone mass speed sound sos measured beginning baseline middle month end study month single blind method sos eggshell group increased significantly significantly higher placebo calcium carbonate groups conclusion eggshell calcium effective increasing bone mass calcium carbonate postmenopausal vietnamese women
patient report describes simultaneous bimaxillary orthognathic surgery mandibular reconstruction means three dimensional planning printed biocompatible surgical wafers selective laser sintered titanium implant year old male patient presented left mandibular defect secondary trauma whole body mandible left hand side deficient narrow connection remaining left condyle undergone orthodontic treatment months ready undergo bimaxillary orthognathic surgery advanced cranio maxillofacial software used processing cone beam computer tomography scan data casts upper lower dental arches bimaxillary surgery planned fort maxillary impaction mandibular advancement achieve class incisor relationship intermediate final surgical wafers designed following planned movements printed using biocompatible resin deficient left side mandible reconstructed means mirror imaging contra lateral right side deficient left side aim restoring normal facial symmetry biomedical software used designing reconstruction plate connected condylar head mandible following planned bimaxillary surgery mandibular continuity symmetry reconstruction plate printed titanium following state art selective laser sintering technology bimaxillary surgery mandibular reconstruction done simultaneously planned along iliac crest bone graft patient confirms advantages computer aided design computer aided manufacture technologies optimizing clinical outcomes cranio maxillofacial reconstruction especially conducting two simultaneous clinical procedures
although hiv services expanding reached scale necessary support universal viral suppression individuals living hiv purpose systematic review summarize qualitative evidence evaluating public health hiv interventions enhance linkage care antiretroviral drug arv adherence retention care searched databases without language restrictions review collated data three separate qualitative evidence reviews addressing three outcomes along care continuum citations identified studies included evidence review among low middle income countries africa men living hiv decreased engagement interventions compared women lack engagement among men also influenced willingness partners engage services four structural issues poverty unstable housing food insecurity lack transportation mediated feasibility acceptability public health hiv interventions individuals living hiv identified unmet mental health needs interfered ability access hiv services persistent social cultural factors contribute disparities hiv outcomes across continuum care shaping context service delivery among important subpopulations authors published elsevier
functional diversification vertebrate globin gene superfamily provides especially vivid illustration role gene duplication whole genome duplication promoting evolutionary innovation example key globin proteins evolved specialized functions various aspects oxidative metabolism oxygen signaling pathways hemoglobin myoglobin cytoglobin cygb trace origins two whole genome duplication events stem lineage vertebrates retention proto genes ancestor jawed vertebrates permitted physiological division labor oxygen carrier function oxygen storage function gene lineage subsequent tandem gene duplication gave rise proto alpha beta globin genes permitted formation multimeric hbs composed unlike subunits alpha beta evolution heteromeric quaternary structure central emergence specialized oxygen transport protein provided mechanism cooperative oxygen binding allosteric regulatory control subsequent rounds duplication divergence produced diverse repertoires alpha beta like globin genes ontogenetically regulated functionally distinct isoforms expressed different stages prenatal development postnatal life ancestor jawless fishes proto genes appear secondarily lost cygb homolog evolved specialized respiratory function blood oxygen transport phylogenetic comparative genomic analyses vertebrate globin gene superfamily revealed numerous instances paralogous globins convergently evolved similar expression patterns similar functional specializations different organismal lineages elsevier inc rights reserved
electrical stimulation acupoint esa releases several endogenous neuropeptides play important roles management pain inflammation esa low high frequencies shown release different neuropepides suggesting various therapeutic effects pain edema major problems ankle sprain however reports effects esa ankle sprain aimed investigate esa reduce pain edema resulting ankle sprain whether difference therapeutic effects low high frequency esa induce ankle sprain sprague dawley rats ankle right hindpaw overextended direction simultaneous inversion plantar flexion stepping force edema paw sprained ankle measured electronic balance plethysmometer respectively esa groups stepping force increased significantly similar degrees esa produced significant rapid decrease ankle edema study demonstrates esa shows comparable analgesic effects esa facilitate reduction edema caused ankle sprain
specific transcription factors sufficient reprogram fully induced pluripotent stem cells types cells findings raise question whether chemical molecules proteins replace transcription factors alter defined cell fate study treated mouse skin fibroblasts msfs bone morphogenetic protein bmp examined intermediate reprogramming msfs stem like cells putative epidermal stem cells isolated ventral skin epidermis adult mouse used confirm reprogramming activity bmp increased proliferation cells cells formed spheroids treated bmp cultured days following bmp treatment characteristics cells changed expressed oct target transcripts nanog sox alkaline phosphatase confirm stem cell potency cells induced differentiation cardiomyocytes stem like cell derived cardiomyocytes exhibited mrna expression cardiac mesoderm markers transcription factor related locus connexin cardiomyocyte marker troponin differentiated cells exhibited contracting masses results suggest bmp mediated somatic stem cell reprogramming may become alternative approach cell therapy
work simplified method evaluation equilibrium composition plasmas consisted monoatomic species proposed multicomponent gas systems resulting thermal ionization spatially uniform mixtures assumed enough rarefied treated ideal gases even multiple ionization steps method developed calculation equilibrium composition mixtures makes use fundamental principles statistical physics equilibrium concentrations mixture components determined integration distribution functions space momentum summation electronic energy levels functions correspond entropy maximum determine unknown parameters systems equations corresponding normalization conditions derived shown systems may reduced one algebraic equation equilibrium temperature known numeral method solve equation proposed special attention given ionized mixtures generated atoms single chemical species situations gas first first second order ionization possible elsevier rights reserved
paper parallel algorithm nonlinear dynamic analysis three dimensional reinforced concrete frame structures based platform graphics processing unit gpu proposed time integration performed using newmark method nonlinear implicit dynamic analysis parallelization strategies presented correspondingly parallel preconditioned conjugate gradients pcg solver gpu introduced repeating solution equilibrium equations time step frames simulated using fiber beam model capture nonlinear behaviors concrete reinforcing bars parallel finite element program developed utilizing compute unified device architecture cuda accuracy gpu based parallel program including single precision double precision verified comparison abaqus numerical results demonstrated proposed algorithm take full advantage parallel architecture gpu achieve goal speeding computation compared cpu
food insecurity lack consistent access sufficient quality quantity food affects estimated million people around world although household food insecurity generally associated poor child nutrition health usa know less household food insecurity child health developing countries particularly lacking research assessing associations household food insecurity children health outcomes may differ child age among children beyond age years low income settings use data population based sample households children ages years leon nicaragua consider household food insecurity associated three measures child health illness anaemia low height age results provide new evidence even mild household food insecurity detrimental children health child age conditions associations household food insecurity child health find food insecurity especially harmful health early childhood continues significant associations health middle childhood ages years discuss potential implications results future child health research policies low income countries john wiley sons ltd
liking brand facebook cause person view favorably liking simply symptom fond brand authors disentangle possibilities find evidence latter brand attitudes purchasing predicted consumers preexisting fondness brands regardless whether consumers like brands social media addition explore possible second order effects examining whether liking brands might cause consumers friends view brand favorably consumers see friend liked brand less likely buy brand relative learn friend genuinely likes brand offline sense meaningful social endorsement taken together five experiments two meta analyses suggest turning liking improved brand attitudes increased purchasing consumers friends may require click button
background green building systems proliferated health outcomes associated costs benefits remain poorly understood objective compare health families moved new green healthy housing control group traditionally repaired housing design setting mixed methods study chicago housing developments participants public housing low income subsidized households apartments individuals main outcome measures self reported health status visual assessment housing condition indoor air sampling medicaid expenditure diagnostic data medicaid expenditures international classification diseases ninth revision codes modeled using generalized linear model distribution log link results housing conditions self reported physical mental health improved significantly green healthy housing study group compared control group dilapidated public housing residents moved hay fever headaches sinusitis angina respiratory allergy asthma severity measured self reported lost school work days disturbed sleep symptoms improved significantly sadness nervousness restlessness child behavior medicaid data exploratory study inconclusive inconsistent self reported health outcomes visual assessment data housing quality hold promise future investigation possible sources bias medicaid data include older age study group changes medicaid eligibility time controlling medicaid costs urban area increased stress associated moving even move better housing conclusion mixed method approach employed describes complex relationships among self reported health housing conditions environmental measures clinical data housing conditions self reported physical mental health improved green healthy housing health care cost savings medicaid due improved housing could quantified hold promise future investigations larger cohorts longer follow period
scope analysis tune proportional integral derivative pid parameters autonomously controlling moisture content paper industry using genetic algorithm particle swarm optimization pso algorithm pso based pid tuning results compared conventional based pid tuning examine performance time domain specifications hence well suited marine application real time prototype model paper machine designed controlled using pic microcontroller embedded programming language model used measure moisture content level paper
care patients shunted hydrocephalus complicated best assessment provided data available neurosurgery practitioner however data time consuming gather especially setting busy practice trainee environment duty hour restrictions electronic medical record emr specifically designed needs subspecialists reasons complete clinical picture especially historical component sometimes assembled address shortcomings authors created patient level electronic csf shunt history tool leverages power emr concordant united states centers medicare medicaid services meaningful use principles immediately available within emr users patient care contexts outpatient inpatient perk operative emergency remote access centrally located designed capture vast range circumstances inherent hydrocephalus population essential shunt data rapidly acquired may decrease likelihood error diagnosis treatment tool also potential aid practicing neurosurgeon clinical quality improvement research standpoints authors endeavored describe tool manner would allow interested neurosurgeon share publication health information technology professionals facilitate development similar tool within institution emr platform
fbg fiber bragg grating sensors appropriate embedding composites manufacturing engineering influence embedding fbg sensors composites tension compression cai properties studied paper results identified mechanical properties decreased obviously certain volume content optical fibers embedded fbg sensor permits continuous monitoring host material embedded middle degree layer consistent strain gauges sensitivity coefficient fbg sensor embedded almost embedded offers important reference value application fbg sensors aerospace composites
ability set realistic expectations treatment response patients overactive bladder oab impact patient engagement adherence study medication order help set treatment expectations oab physician predictive tool developed based predictive modelling models developed utilizing data eight phase fesoterodine clinical trials models enable prediction individual treatment response subjects oab based various baseline characteristics data utilized covariates hypothesized influence treatment response described model selection development process also outlined final model example results utilizing model presented finally discuss potential benefits limitations predictive tool published elsevier inc
headache important cause minor postoperative morbidity study evaluated association anesthesia surgery occurrence postoperative headache elective surgery patients obtaining ethical approval patients enrolled prospective single centre cohort study participants interviewed preoperatively five days postoperatively regarding appearance headache demographics lifestyle type anesthesia surgery anesthetic drugs administered intraoperative adverse effects recorded multiple logistic regression analysis conducted order identify independent factors associated postoperative headache total sample patients without previous history headache observed overall frequency postoperative headache total sample patients previous history headache frequency postoperative headache history frequency postoperative headache female gender odds ratio sevoflurane administration intraoperative hypotension smoking independently associated postoperative headache patients without previous history female gender sevoflurane administration intraoperative hypotension caffeine consumption presented greater likelihood postoperative headache smoking revealed association female gender sevoflurane smoking intraoperative hypotension documented independent risk factors postoperative headache patients previous history headache caffeine consumption additional independent factor postoperative headache smoking revealed association
propose stronger halo effects trait assessments positive information relative negative information due positive information higher similarity positive information foster indirect global impression traits direct halo effects traits traits negative information relative distinctiveness foster direct halo effects leading weaker halo effects overall four experiments support predictions using agency traits communion traits behaviors supporting predictions halo effects positive information visible within communion agency information communion agency traits across agency communion information communion agency traits fundamental dimensions social perception halo effects negative information visible within dimensions study thereby explains halo effects negative information usually weaker supports different processes underlying halo effects provides case person perception positive information impact negative information
background bipolar disorder one complex mental illnesses characterized interactive depressive manic states contrary symptoms disease states bilateral amygdala prefrontal cortex pfc appear play critical roles however abnormalities seem manifest differently states may provide insight underlying mechanisms methods sixteen participants first episode depressive participants first episode manic states bipolar disorder well healthy control participants underwent resting state functional magnetic resonance imaging fmri resting state functional connectivity rsfc bilateral amygdala pfc compared among groups results compared depressive state participants group manic state participants group showed significant decrease rsfc amygdala right orbital frontal cortex corrected addition rsfc amygdala left middle frontal cortex significantly decreased depressive manic state participants group compared group corrected conclusions findings suggest mood state first episodes may related abnormality hemispheric lateralization abnormalities amygdala left pfc functional connectivity might present trait feature deficits amygdala right pfc functional connectivity might specific manic episode compared depressive episode elsevier rights reserved
microbiological quality drinking water concern consumers water suppliers regulators public health authorities alike monitoring microbiological quality drinking water largely relies examination indicator bacteria coliforms like escherichia coli coli widely used indicator fecal pollution monitoring microbial quality drinking water abundant mammal feces therefore found sewage natural waters contaminated fecal matter human origin wild animals derived agricultural activity paper describes development novel handheld fluorimeter rapid detection coli drinking water based specific cellular biomarker measurement system based photomultiplier tube captures fluorescence signal produced cellular biomarker excited ultraviolet led cellular biomarker also developed consists chimeric protein green fluorescent protein gfp terminal domain specific amino acid sequence terminal domain colicin targets specifically structure microorganism detected instrument simple use lightweight powered either power adapter rechargeable battery making excellent choice rapid detection coli drinking water field studies laboratory measurements
objectives aims study explore relationship baseline levels natriuretic peptides nps outcomes test interaction baseline levels nps effects spironolactone background plasma nps considered helpful diagnosis heart failure preserved ejection fraction hfpef elevated levels associated adverse outcomes levels nps higher certain cutoffs often used inclusion criteria clinical trials hfpef increase likelihood patients select patients higher risk events whether treatments differential effect outcomes across spectrum levels unclear methods topcat treatment preserved cardiac function heart failure aldosterone antagonist trial trial randomized patients hfpef either prior hospitalization elevated natriuretic peptide levels type bnp terminal probnp spironolactone placebo baseline bnp terminal probnp levels available patients enrolled americas elevated stratum topcat results higher levels nps independently associated increased risk topcat primary endpoint cardiovascular mortality aborted cardiac arrest hospitalization analyzed either continuously grouped terciles adjusting region enrollment age sex atrial fibrillation diabetes renal function body mass index heart rate significant interaction effect spironolactone baseline terciles primary outcome greater benefit drug lower compared higher terciles conclusions similar effects irbesartan preserve irbesartan heart failure preserved ejection fraction trial greater benefit spironolactone observed group lower levels nps overall risk topcat elevated nps hfpef identify patients higher risk events may less responsive treatment mechanism apparent interaction disease severity response therapy requires exploration published elsevier behalf american college cardiology foundation
methods polynomial eigenvalue problem sometimes need followed iterative refinement process improve accuracy computed solutions accomplished means newton iteration tailored matrix polynomials computational cost step usually higher cost computing initial approximations due need solving multiple linear systems equations bordered coefficient matrix effective parallelization thus important propose different approaches message passing scenario schemes use subcommunicator strategy order improve scalability whenever direct linear solvers used show performance results various alternatives implemented context slepc scalable library eigenvalue problem computations copyright john wiley sons ltd
study proposes new proportionalintegralderivative pid controller auto tuners using frequency sampling filters fsfs estimation plant frequency response information relay feedback control differs existing auto tuners estimation plant frequency response information utilisation frequency domain based pid controller design desired closed loop time constant selected user scaling factor estimated open loop time constant simulation examples used demonstrate efficacy auto tuner characteristics disturbance rejection reference following indicating auto tuner produces satisfactory closed loop control performance commonly encountered systems process control addition monte carlo simulation studies used demonstrate fsf model based algorithm requires shorter experimental time achieve higher accuracy estimation also provides much improvement traditional fourier analysis based approaches disturbances encountered relay experiments
transmission towers play important role transmitting electricity power grid safely reliably traditional design practice second order delta frame side sway delta member curvature effects joint effects load eccentricities slippage effects semirigid connection commonly ignored analysis great discrepancy frequently noted full scale tower tests numerical simulations using first order linear analysis paper second order direct analysis used slippage bolted joints well semirigid connection behavior taken account member initial bowing frame plumbness imperfections considered present study verified full scale test ultrahigh voltage uhv lattice transmission tower technique semirigid design simulation joint stiffness load eccentricity simple modeling transmission towers meeting requirements direct analysis verification full scale test unavailable literature proposed paper furthermore influences joint slippage deflection load behavior studied towers quantified reported american society civil engineers
grinding employs abrasive product usually rotating wheel brought controlled contact workpiece surface grinding patterning process simulated using computer programming specific user defined parameters predict surface pattern result grinding grooved wheel calculating cam parameters important intention research formulate cam parameters generation surface pattern flat nominal surface grinding wheel prepared special way diamond dresser rounded tip applied prepare helical grooves conventional wheel surface intention extracting cam parameters mathematical model developed grinding patterning process starting unit pattern geometry workpiece plate models characterized process parameters grinding patterning unit pattern geometry dressing parameters wheel geometry grinding conditions well work surface geometry computer program user interface developed using matlab according proposed mathematical model predict surface pattern addition several examples simulation results wheel geometry model corresponding patterned surfaces displayed using proposed cam parameters input formulated cam parameters used control actual grinding process predict ground surface pattern
analysis presents differences acute work injury rates among electric utility linemen perform different work tasks incidence density rate ratios primary measure association based work injury per son time data job title logistic regression used model race age job experience total inservice prior injury time prior injury transmission linemen lower acute injury rate per person work years distribution linemen per person work years apprentice linemen per person work years injuries trunk sprains strains predominant injury categories prior lost time injury increases risk subsequent lost time injury transmission linemen distribution linemen wiley liss inc
china population ages importance determining prevalence cervical disease accurate cervical cancer screening strategies postmenopausal women increasing seventeen population based studies analyzed determine prevalence cervical neoplasia postmenopausal women women underwent hpv dna testing visual inspection acetic acid via cytology testing diagnostic values primary combinations screening methods included sensitivity specificity positive predictive value ppv negative predictive value npv referral rate area curve auc calculated using directed biopsy four quadrants biopsy reference standard premenopausal postmenopausal women equal hpv infection cervical neoplasia rates hpv dna testing cin sensitivity specificity ppv npv referral rate auc respectively via values respectively values via hpv triage respectively via hpv dna test values respectively via sensitivity decreases significantly postmenopausal women compared premenopausal performance hpv dna testing maintains performance pre postmenopausal women accurate primary modality screening postmenopausal populations low resource areas china new study sought investigate feasible screening strategies increasing postmenopausal population china similar disease burden premenopausal postmenopausal women via significant drop diagnostic performance postmenopausal women compared premenopausal diagnostic performance hpv dna testing best sensitivity postmenopausal women significant difference performance pre postmenopausal women
paper explores performance converter based current mode controller photovoltaic simulator emulates output characteristics real module portable simulator prototype examined terms steady state curve matching capacity convergence time corresponding step change current source load voltage source load insolation levels current voltage characteristics module implemented look table lut determines reference output current measured output voltage thevenin equivalent method approach arrays analysis also included order model small signal linearized characteristics extensive simulation results obtained mat lab included show simulator work situations real module preliminary experimental results verify performance current source voltage source loads
examined whether types interpolated tasks retrieval practice via free recall guessing missing critical item improved final recognition related unrelated word lists relative restudying completing filler task retrieval practice guessing tasks improved correct recognition relative restudy filler tasks particularly study lists semantically related however retrieval practice guessing also generally inflated false recognition nonpresented critical words patterns found final recognition completed short delay within experimental session experiment delay experiment experiment task instructions presented randomly list determine whether retrieval practice guessing effects influenced task expectancy processes contrast experiments final recognition retrieval practice guessing equivalent restudy suggesting observed retrieval practice guessing advantages part preparatory task based processing study
lot wind power plants based double feed induction machine technology connected electrical network usually consider reactive power even reactive power consumption generally affect entire network voltage stability cause instability become longer balanced torque paper presents method study relationship active power voltage point common coupling pcc connected wind power plant identify voltage stability limit fundament define permitted operation region complying voltage stability limit pcc connected wind power
aimsthis pilot study evaluate feasibility using diagnostic cardiac electrophysiology catheters recording intrinsic urinary bladder electrical activity electrical pacing capture bladder tissue methodsduring cystoscopy curved quadripolar catheter introduced contact made right left halves dome trigone adult female patients undergoing cystoscopy electrical activity recorded using commercially available cardiac electrophysiologic recording system pacing resultsapparent spontaneous electrical depolarizations detected trigone dome amplitude depolarizations microvolt range pacing local electrical capture noted trigone dome conclusionsspontaneous low amplitude electrical activity detected bladder use commercially available cardiac electrophysiology equipment low level signals could represent noise voltage morphology resemble detrusor muscle action potentials previously seen animal studies pacing induced local electrical capture trigone dome
background task shifting become increasingly popular way increase access health services especially low resource settings research demonstrated task shifting including use community health workers chws deliver care improve population health systematic review investigates whether task shifting low income middle income countries lmics results efficiency improvements achieving cost savings methods using prisma guidelines systematic reviews searched pubmed embase cinahl health economic evaluation database march included original peer review articles demonstrated cost impact task shifting program lmic results identified articles included study found substantial evidence exists achieving cost savings efficiency improvements task shifting activities related tuberculosis hiv aids additional evidence exists potential achieve cost savings activities related malaria ncds ntds childhood illness disease areas especially primary health care community levels conclusions task shifting presents viable option health system cost savings lmics going forward program planners carefully consider whether task shifting improve population health health systems efficiency countries researchers investigate whether task shifting also achieve cost savings activities related emerging global health priorities health systems strengthening activities supply chain management monitoring evaluation
emerging infectious diseases elds always one major threats public health although implementation mandatory testing classical transfusion transmitted infectious human immunodeficiency virus hepatitis virus hepatitis virus syphilis reduced transfusion risk pathogens potential threat various eid agents constantly evolving variants blood safety china fully understood review presents representative eid agents autochthonous epidemic nationally regionally china epidemiologic status distribution eid agents among donors healthy populations summarized potential risks eid agents blood safety discussed review also explores strategies strengthen hemovigilance systems studies evaluate impact eid agents blood safety elsevier inc rights reserved
introduction angioedema localized self limiting edema subcutaneous submucosal tissue hereditary angioedema inhibitor deficiency inh hae best characterized form hereditary angioedema inh hae reduced plasma levels inh cause instability contact system release bradykinin key mediator angioedema inh hae characterized recurrent skin swelling abdominal pain potentially life threatening upper airways obstruction knowledge molecular mechanisms leading inh deficiency angioedema allowed development several therapies areas covered aim review article discuss safety currently available treatments inh hae authors give insight mechanism action safety profile drugs treatment acute attacks short long term prophylaxis evidence systematic reviews clinical trials retrospective studies case reports summarized review expert opinion inh hae disabling life threatening condition lasts life long different therapeutic approaches different drugs provide significant benefit patients safety profiles therapies critical optimal therapeutic decision need known inh hae treating physicians appropriate risk benefit evaluation
objectives objective study investigate factors condom use among sample sexually active chinese college students methods cross sectional survey systematic sampling conducted students interpersonal sexual communication media exposure condom use multiple regression employed analysis results self efficacy peer partner sexual communication parent norms condom usage hiv aids information brochures exposure sexual content books associated variables related condom use conclusions current study underscores importance self efficacy peer partner sexual communication hiv preventive intervention programs promote condom use among young chinese
introduction hyperprolactinemia common serious side effect antipsychotic medications currently used treatment patients schizophrenia pharmacogenetic approaches offer possibility identifying patient specific biomarkers predicting risk side effect investigated possible relationship variants snps genes cytochrome cypd dopamine receptor drd serotonin receptor htrc antipsychotic drug induced hyperprolactinemia patients schizophrenia methods overall russian patients paranoid schizophrenia aged included serum prolactin concentration measured elisa dna analysis genotyping cypd drd htrc genes done steponeplus real time pcr system using taqman snp genotyping assays applied biosystems usa results study showed association cypd htrc gene polymorphism hyperprolactinemia patients schizophrenia background therapy associations identified drd gene polymorphism risk antipsychotic induced hyperprolactinemia patients schizophrenia conclusion study confirms contribution genetic factors antipsychotic induced hyperprolactinemia patients schizophrenia studies required unravel genetic predictors antipsychotic induced side effects develop personalized treatment strategies patients schizophrenia
attempt made study drainage morphometry influence hydrology peddavanka watershed south india drainage networks sub basins derived topographical map shuttle radar topographic mission srtm digital elevation model dem data used preparing elevation slope aspects maps geographical information system gis used evaluation linear areal relief aspects morphometric parameters study reveals srtm dem gis based approach evaluation drainage morphometric parameters influence hydrological characteristics watershed level appropriate conventional methods mean bifurcation ratio entire basin indicate drainage pattern much influenced geological structures viii sub basin high elongation ratio basin relief ruggedness number time concentration indicates erosion peak discharges high basins therefore construction check dams earth dams help reducing peak discharge main channel studies useful implementing rainwater harvesting watershed management
prospective single center observational study compared impedance cardiography electrical velocimetry transthoracic echocardiography tte based trans aortic flow analyzed influence physiological shunts patent ductus arteriosus pda patent foramen ovale pfo measurement accuracy two hundred ninety one triplicate simultaneous paired left ventricular stroke volume lvsv measurements lvsvev tte lvsvtte spontaneously breathing neonates mean weight range included whole cohort mean absolute lvsvev mean lvsvtte resulting absolute bland altman bias limits agreement loa relative bias mean percentage error mpe true precision tpev aggregated data points neonates without shunts mean lvsvev mean lvsvtte bland altman bias loa relative bias mpe tpev neonates shunts pda pfo mean lvsvev mean lvsvtte bias loa relative bias mpe tpev accuracy affected pda pfo significant increase relative difference lvsvev versus lvsvtte subjects without shunts pfo alone pda alone pda pfo physiological shunts pda pfo neonates affect measurement accuracy cause overestimation lvsvev compared lvsvtte
psychostimulants induce stable changes neural plasticity behavior transcription dependent manner stable cellular changes require transcription regulated epigenetic mechanisms alter chromatin structure histone acetylation mechanism typically catalyzed enzymes histone acetyltransferase histone deacetylase hdac activity class ila hdac notable high expression important regions brain reward circuitry neural activity dependent shuttling cell nucleus particular hdac important modulatory function cocaine induced behaviors social defeat stress induced effects although mutation hdac shown cause hypersensitive responses chronic cocaine use whether response worsens chronic early life stress examined yet study exposed mouse pups two different early life stress paradigms social isolation esi social threat est determine whether heterozygous null mutation hdac hdac moderated effects exposure stress early life adult cocaine induced conditioned place preference cpp notably hdac mice exposed esi susceptible developing cocaine induced cpp resistant extinguishing behavior effect observed hdac mice experiencing est suggesting esi induces behavioral changes acting precisely hdac related biological pathways finally analysis fos expression performed discover neurobiological substrates mediated phenotype identified dorsolateral striatum important structure mediates interaction hdac mutation esl data demonstrate decreased hdac function able exacerbate long term behavioral effects adverse rearing environment mouse elsevier inc rights reserved
baby factories baby harvesting relatively new terms involve breeding trafficking abuse infants biological mothers since first described united nations educational scientific cultural organization report nigeria several baby factories discovered years infertile women noted major patrons baby factories due stigmatization childless couples southern nigeria issues around cultural acceptability surrogacy adoption practices contributed growth industry results physical psychological sexual violence victims tackling baby factories involve multifaceted approach includes advocacy enacting legislation barring baby factories infant trafficking harsh consequences patrons also programs educate young girls preventing unwanted pregnancies needed methods improving awareness acceptability adoption surrogacy reducing administrative legal bottlenecks associated options infertile couples explored diminish importance baby factories
relationship cortical grey matter density media violence exposure healthy male adolescents investigated using voxel based morphometry childrens report exposure violence adolescents frequent exposure lower left lateral orbitofrontal cortex density possible risk factor altered socioemotional functioning society adolescent health medicine rights reserved
present work part hand hope project seeks develop low cost robotic hand prostheses aim contributing social labor inclusion people upper limb motor disabilities living developing countries objective work design deploy grasp control system enable robotic prosthesis perform object catch functions purposes evaluating system five grasp elemental functions defined relaxed hand cylindrical grip pinch grip thumb adduction index finger extended design phase estimated compared mathematical model unstable system based two experimental methods model based reference transfer function model based inverse laplace transform output signal implementation phase control function based ziegler nichols closed loop method tuned finally results evaluated prototype robotic hand prosthesis utpl ecuador results obtained within defined control requirements settling time equal seconds overshoot steady state error zero
convergence analysis numerical methods solving partial differential equations finite element methods one arrives certain generalized eigenvalue problems whose maximal eigenvalues need estimated accurately possible apply symbolic computation methods situation square elements able improve previously known upper bound given finite element methods schwab factor precisely try evaluate corresponding determinant using holonomic ansatz powerful tool dealing determinants proposed zeilberger however turns method succeed problem hand solution present variation original holonomic ansatz applicable larger class determinants including one dealing obtain explicit closed form determinant whose special form enables derive new tight upper resp lower bounds maximal eigenvalue well asymptotic behaviour elsevier inc rights reserved
background gold compounds shown promise treatment non communicable diseases rheumatoid arthritis cancer considered value anti microbial agents gram negative gram positive bacteria anti parasitic properties schistosoma mansoni trypanosoma brucei plasmodium falciparum leishmania infantinum giardia lamblia entamoeba histolytica known affect enzymatic activities required cellular respiration processes methods anti amoebic effects phosphanegold thiolates tested clinical isolate castellanii belonging genotype employing viability assays growth inhibition assays encystation assays excystation assays zymographic assays results treatment castellanii phosphanegold thiolates tested effect viability castellanii determined trypan blue exclusion test affect amoebae growth using pyg growth medium iii inhibit cellular differentiation effect extracellular proteolytic activities castellanii conclusion free living amoeba castellanii versatile respirator possesses respiratory mechanisms adapt various aerobic anaerobic environments avoid toxic threats adverse conditions first time findings showed castellanii exhibits resistance toxic effects gold compounds could prove attractive model study mechanisms metal resistance eukaryotic cells
concept microalbuminuria central development clinical practice research area diabetic kidney disease dkd however recent times value paradigm dkd based solely microalbuminuria questioned although absolute level rate change microalbuminuria linked development progression dkd microalbuminuria lacks necessary sensitivity specificity accurately predict kidney outcomes people diabetes development microalbumiuria longer viewed committed irreversible stage dkd spontaneous remission reported common occurrence addition absence microalbuminuria progression proteinuria signify individual patient safe progressive decline glomerular filtration rate gfr furthermore although reductions albuminuria within microalbuminuric range linked slower gfr decline observational studies relationship robustly demonstrated intervention studies conclusions regarding kidney health individuals diabetes continue flawed inappropriate emphasis placed presence absence albuminuria changes albuminuria within microalbuminuric range important implications terms undermining value microalbuminuria surrogate renal end point intervention trials need develop broader models progressive dkd include novel pathways risk markers apart related traditional albuminuric pathway renal impairment
proximal urethra urinary bladder trigone play important roles continence previously shown pgd released guinea pig bladder urothelium suburothelium inhibit detrusor contractile responses presently wished investigate pgd actions guinea pig flow region distribution receptors effects pgd urothelium intact trigone proximal urethra contractility studied organ bath experiments expression receptor proteins analysed western blot immunohistochemistry used identify distribution receptors pgd dose dependent manner inhibited trigone contractions induced electrical field stimulation efs inhibited spontaneous contractions proximal urethra pgd equally trigone slightly less potent urethra compared pge expression receptors found male guinea pig bladder trigone neck proximal urethra trigone proximal urethra receptors found membrane smooth muscle cells weak immunoreactivty observed urothelium receptors distributed widespread weakly evenly urothelium smooth muscles inhibitory effects pgd motor activity guinea pig trigone proximal urethra consistent finding receptors located urothelium smooth muscle cells trigone proximal urethra pgd may therefore modulator bladder flow region possibly function regulation micturition role overactive bladder syndrome
background neurodegenerative disorders deficits learning memory cognition alzheimer disease associated diabetes mellitus brain derived neurotrophic factor bdnf neurotrophic factor known possess anti obesity anti diabetic actions believed role memory alzheimer disease objective investigate whether stz reduce bdnf production rat insulinoma rinf cells vitro decrease bdnf levels pancreas liver brain vivo methods streptozotocin stz induced cytotoxicity rinf cells vitro type wistar rats employed present study cell viability activities various anti oxidants secretion bdnf rinf cells vitro measured using mit assay biochemical methods elisa respectively stz induced type rats plasma glucose interleukin tumor necrosis factor alpha levels bdnf protein expression pancreas liver brain tissues measured addition neuronal count morphology hippocampus hypothalamus areas assessed results stz induced suppression rinf cell viability abrogated bdnf stz suppressed bdnf secretion rinf cells vitro stz induced type rats showed hyperglycemia enhanced plasma tnf alpha levels reduced plasma pancreas liver brain tissues increased oxidative stress compared untreated control hypothalamic hippocampal neuron stz treated animals showed decrease number neurons morphological changes suggesting stz cytotoxicity conclusions results present study suggest stz cytotoxic pancreatic beta cells also hypothalamic hippocampal neurons inducing oxidative stress stz ability suppress bdnf production pancreas liver brain tissues suggests impaired memory learning cognitive dysfunction seen diabetes mellitus could due bdnf deficiency elsevier inc rights reserved
paper devoted design analysis gastroenterology clinic digestive health center dhc university wisconsin health dhc consolidate several existing clinic endoscopy locations single center first work flow current clinic studied markov chain model developed extended non markovian case evaluate patient average length stay staff utilization model validated data observed clinic shown model provide accurate estimation system performance using model design options new clinic dhc studied investigate impact different system configurations analyses carried different patient check processes investigated finally recommendations enhancing service new clinic proposed dhc leadership
accessible summary known subject recently concerns raised well united kingdom national health service nurses care patients level compassion motivational interviewing established approach helping people make positive behaviour changes directive person centred counselling within collaborative relationship clinician recipient based evidence may influence nursing practice positively investigation feasibility training nurses mental health inpatient rehabilitation wards rehabilitation improve patient experience reported paper adds existing knowledge pilot study demonstrates training rehabilitation nurses feasible provides preliminary evidence suggesting larger study examine efficacy warranted including calculation sample size required draw robust statistical conclusions nurses evaluated training highly relevant work patients responded well interviews focus groups support experts experience generally fairly satisfied rehabilitation ward slight improvements experience found following training nurses month follow implications practice rehabilitation nurses may face conflicting demands ensuring patients severe difficulties meet basic needs working develop greater independence qualitative findings question whether nurse patient interactions fully valued nursing interventions inpatient rehabilitation learning might useful way helping nurses think detail interactions patients improve communications patients principles incorporated pre registration training abstract introduction limited research addressing experiences patients inpatient rehabilitation rehabilitation often spend long periods hospital nursing approaches utilized aim based evidence motivational interviewing may improve nursing practice pilot study evaluating feasibility training rehabilitation nurses measuring patient experience method nurses underwent training supervision focusing spirit quantitative qualitative measures taken pretraining months post training months post training expert experience research assistants facilitated patients participation study results study showed training rehabilitation nurses feasible relevant work patients participated interviews focus groups support potential improvements require empirical investigation patient experience found following training discussion pilot study establishes feasibility larger study addressing efficacy tentative qualitative findings question whether interactions nurses patients valued rehabilitation support promising skill set rehabilitation nurses implications practice bringing inpatient rehabilitation provoked reflection nursing practice dilemmas nurses balancing safety promoting autonomy communicating constructively patients emerged important
dance movement intrinsically connected rhythm music fundamental form nonverbal communication present daily human interactions order enable robots interact humans natural real world environments dance robots must able listen music robustly tracking beat continuous musical stimuli simultaneously responding human speech paper propose integration real time beat tracking system state recovery different preprocessing solutions used robot audition application interactive dancing robots proposed system assessed different real world acoustic conditions increasing complexity consider multiple audio sources different kinds multiple noise sources different natures continuous musical speech stimuli effects beat synchronous ego motion noise jittering ego noise overall results suggest improved beat tracking accuracy lower reaction times music transitions still enhancing automatic speech recognition asr run parallel challenging conditions results corroborate application proposed system interactive dancing robots
aim aimed identify clinical characteristics risk factors associated onset high altitude headache hah acute exposure method two hours individuals ascended plane demographic information physiological psychological measurements cognitive function physical work capacity tests profile mood states within one week prior departure within hours arrival examined results hah patients featured significantly higher vertebral artery diastolic velocity heart rate pulmonary artery diameter hah also associated negative mood state including scores tension anxiety depression hostility fatigue confusion well lower vigor values furthermore negative emotions positively related hah severity hah slightly decreased cognitive functioning lack vigor confusion self reported anxiety values independent risk factors hah identified three independent baseline predictors hah including internal diameter left ventricle lvd athens insomnia scale ais confusion score conclusions higher confusion self reported anxiety insufficient vigor independent risk factors hah furthermore higher baseline lvd ais confusion score independent predictors hah
conditions experienced prenatal development long lasting organizational effects offspring maternal carotenoids deposited eggs birds oviparous species play important role fast embryonic growth chick development antioxidant properties however long term consequences variation maternal carotenoid transfer offspring seldom considered since plasma carotenoid levels adulthood known influence testis size yolk carotenoid levels influence ability extract carotenoids later life hypothesized maternally transmitted carotenoids might influence gonad size adulthood showed male japanese quail coturnix japonica originating carotenoid enriched egg smaller testes control individuals adulthood result shows yolk carotenoids long term organizational effects addition given carotenoid intake sexual maturity increases sperm quality decreased testis size associated lower sperm production propose carotenoid exposure embryo development might influence trade ejaculate size sperm quality
paper addresses generation accurate efficient macromodels high speed input output buffers proposed modeling approach extends state art methods currently available yielding modular scalable tool model generation modeling procedure applies single ended differential devices possibly exhibiting rich dynamical behavior due large supply fluctuations internal voltage regulators models defined combination static surfaces described via compact tensor approximations linear dynamical state space relations generated using robust time domain vector fitting algorithm simple effective solution adopted account overclocking operation output buffer models well feasibility strength proposed method demonstrated using real devices complex application test cases signal power integrity cosimulations
generally reservoir simulation results show considerable distance actual behavior system mainly due poor initial estimates model parameters problem improving property estimates using reservoir observations called history matching essential inseparable part reservoir studies recent years promising tool control engineering called ensemble filtering used history matching problems could used quantify uncertainty predictions paper focuses comparison traditional ensemble kalman filter enkf relatively new form ensemble filters called finite size ensemble transform kalman filter small size benchmark model study tries estimate porosity permeability fields assimilating production data time steps weighting approach used modification filter procedure results show traditional ensemble kalman filter localization better performance problem small ensemble superiority comes computational cost elsevier rights reserved
introduction risky sexual behaviours recognized threat sexual reproductive health aim article shows results sportello salute giovani project youth health information desk relation determining large sample university students italy cope preconception health especially domains sexual transmitted infections stis fertility vaccination preventable disease methods twentythree questions sportello salute giovani survey sexual behaviour reproductive health analysed besides results stratified sex age class socio economic status results students first sexual intercourse age female students used emergency contraception sexual active students reported using contraceptives used methods ineffective stis general low coverage rubella measles mumps vaccination revealed men woman never urologic gynaecological examinations discussion overall young adults italy still enough sensitized fertility preconception care high schools universities increase awareness towards preservation male female fertility preconception care
parents children diagnosed disabilities often experience elevated levels stress compared parenting children without disabilities baker ericzen brookman frazee stahmer tomanik harris hawkins increase stress negative impact parent well trute hiebert murphy resulting stress induced dysregulation immune system article issue gouin estrela desmarais baker found increased levels social support served protection dysregulation current study examined nature beneficial components formal support services targeted reducing stress levels parental caregivers children developmental disabilities meta analytic review attempt examine efficacy interventions potential moderators effects reviewing comparison group studies conducted north america parent stress interventions stress outcome measures six studies identified met review criteria reporting overall effect sum stress management interventions found effectively reduce reported stress parents caring children developmental disabilities significant issue identified limited number comparison group studies examined stress management interventions population implications findings need exploration discussed
background result recent advances biotechnology many findings related intracellular systems published transcription factor information although reproduce biological systems incorporating findings describing dynamics mathematical equations simulation results inconsistent data biological observations inaccurate unknown parts constructed system completion systems relationships among genes inferred several computational approaches typically apply several abstractions linearization handle heavy computational cost evaluating biological systems however since approximations generate false regulations computational methods infer regulatory relationships based less abstract models incorporating existing knowledge strongly required results propose new data assimilation algorithm utilizes simple nonlinear regulatory model state space representation infer gene regulatory networks grns using time course observation data estimation hidden state variables parameter values developed novel method termed higher moment ensemble particle filter hmenpf retain first four moments conditional distributions filtering steps starting original model derived literature proposed algorithm sequentially evaluate candidate models generated partially changing current best model find model best predict data performance evaluation generated six synthetic data based two real biological networks evaluated effectiveness proposed algorithm improving networks inferred previous methods applied time course observation data rat skeletal muscle stimulated corticosteroid since corticosteroid pharmacogenomic pathway kinetic dynamics candidate genes partially elucidated incorporated findings inferred extended pathway rat pharmacogenomics conclusions simulation study proposed algorithm outperformed previous methods successfully improved regulatory structure inferred previous methods furthermore proposed algorithm could extend corticosteroid related pathway partially elucidated incorporating several information sources
fact quality water river getting worse especially ciliwung river contaminated non point source pollutant household wastes particularly downstream ciliwung river lied using technology remote sensing integrated information data digital image modeling technology simulation water quality provide easiness observation quality water changes river surface one example use land settlements housing ranges downstream ciliwung river give significant picture seeing factors affected water quality ciliwung river
low digestible carbohydrates represent class enzyme resistant saccharides specific effects human gastrointestinal tract small bowel affect nutrient digestion absorption glucose lipid metabolism protect known risk factors cardiovascular disease colon mainly degraded anaerobic bacteria process called fermentation consequence faecal nitrogen excretion enhanced used clinically prevent treat hepatic encephalopathy low digestible carbohydrates trophic epithelia ileum colon helps avoid bacterial translocation short chain fatty acids important fermentation products evaluated new therapeutics acute colitis considered primary prevention colorectal cancer bifidogenic effect fructo oligosaccharides merits attention unfermented carbohydrates increase faecal bulk play role treatment chronic functional constipation symptomatic diverticulosis possibly irritable bowel syndrome conclusion low digestible carbohydrates may play role maintenance human digestive health however strength evidence differs disease entities
national hiv aids strategy renewed goal increasing access care people living hiv aids plwha called increased focus linkage care efforts many plwha face multiple barriers care live margins society adoption intensive outreach activities necessary engage disenfranchised plwha care ultimately end hiv epidemic bay area network positive health banph comprising agencies established network outreach model linkage care project engage hardest reach populations san francisco bay area years banph agencies conducted street outreach analyzed internal tracking systems identify care individuals individuals experiencing tenuous care surveyed participants using apple ipod touch devices year project banph agencies engaged care plwha linked care average outreach workers made contact attempts client link care sixty three percent participants linked care average days initial contact factors including lack case management lack transportation competing concerns substance abuse hiv stigma significantly associated linkage care outcomes intensive outreach efforts could help reduce barriers care hard reach plwha efforts require tremendous amount time resources network outreach model could help facilitate sharing limited resources increase regional outreach capacity linkage care programs
paper explore new applications exponential rational function method scalar qiao equation kuramoto sivashinsky equation obtained solutions may significance explanation practical physical problems method suitable easy effective handling solution process nonlinear equations physical society republic china taiwan published elsevier rights reserved
recently interest towards electrostatic actuators machinery increased use mems mechatronics renewable energy applications effective electromechanical power conversion using electrostatics requires dielectric liquids whose permittivity breakdown field strength facilitate adequate electric shear stress pressure beyond capabilities media air vacuum paper discusses design points practical electrostatic force production evaluates available shelf dielectric liquids terms electric pressure capability key dielectric properties including pressure breakdown field strength relative permittivity conductivity measured custom test stand measures attractive force two electrodes mounted load cells inside tank filled liquid test measurements demonstrate liquids capable reaching several psi electric pressure correlating analytical finite element models ultimately forming basis electrostatic actuator machine design best liquid candidate vertrel poured proof concept macro scale electrostatic machine demonstrating torque torque measurements verify capability vertrel correlation electric pressure shear stress rotating machine
paper describes squaring square rooting circuits operable low voltage supplies application proposed hereby vector summation four quadrant multiplier circuits circuits make use flipped voltage follower fvf fundamental circuit detail classification basic topologies derived fvf given proposed circuits simple structure wide input range low power consumption well small number devices circuits also examined supported set simulations pspice program circuits operate power supply volts input voltage range squaring circuit volts relative error power dispersion input current square rooting circuit relative error power dispersion vector summation circuit linearity error power dispersion four quadrant multiplier circuit total harmonic distortion multiplier less input signal mhz fundamental frequency experimental result carried confirm operation using commercial cmos transistor arrays circuits highly expected effective application low voltage analog signal processing
purpose study evaluate effect tunas mekar programme student entrepreneurial intention terms personal feasibility starting business objective study identify levels personal feasibility among tunas mekar apprentice involving business identify factors influencing apprentice involve business mean analysis used identify factors influencing apprentice involving business understanding factors level personal feasibility involving business among students give input towards policy makers develop appropriate educational programmes encourage students involve business reduce employability
aim paper assess clinical effectiveness novel ultrasound approach estimation bone fragility total female patients years recruited underwent conventional dxa investigations lumbar spine proximal femur abdominal scan lumbar spine frax questionnaire calculation osteoporotic fracture probabilities acquired data analyzed automatic algorithm calculated fragility score parameter estimates skeletal fragility dedicated spectral statistical analyses showed good correlation reliable fracture risk predictions obtained frax since correlation level frax outcomes much better lumbar bmd one vertical bar vertical bar similar obtained femoral neck bmd vertical bar vertical bar potential become simple non ionizing method bone fragility assessment elsevier ltd rights reserved
objective purpose study examine well flourishing adolescents asthma well factors influencing flourishing adolescents methods secondary analysis data collected national survey children health conducted flourishing adolescents without asthma compared parent coping anger child sex age child flourishing examined adolescents asthma results youth asthma lower flourishing without disease positive parent coping related flourishing parent anger negatively influenced flourishing adolescents asthma interaction terms significant indicating aforementioned variables interacted adolescent age sex conclusions study results point complex relationship parent adolescent level factors adolescent well research needed examine relations among flourishing health outcomes youth asthma
objectives potential use garlic prevention treatment different types headaches suggested several medieval literatures cortical spreading depression csd propagating wave neuroglial depolarization established target anti migraine drugs study designed investigate effect garlic extract csd adult rats methods csd induced kcl microinjection somatosensory cortex effects five different concentrations garlic oil tested different characteristic features csd necocortical slices vivo experiments effects garlic oil electrophysiological morphological changes induced csd investigated results garlic oil dose dependent manner decreased amplitude csd duration velocity neocortical brain slices garlic oil concentration reversibly reduced amplitude field excitatory post synaptic potentials inhibited induction long term potentiation third layer neocortical slices vivo studies systemic application garlic oil three consecutive days reduced amplitude repetition rate csd garlic oil also prevented csd induced reactive astrocytosis neocortex discussion garlic oil suppresses csd likely via inhibition synaptic plasticity prevents harmful effects astrocyte studies required identify exact active ingredient garlic oil inhibit csd may potential use treatment csd related disorders
introduction cardiac effect different pulmonary functions six minute walk distance arterial blood gases saturation interstitial lung disease ild much known study tertiary care hospital experience entails know various factors pulmonary hypertension mentioned causing correlation aim study correlation patients ild spirometry six minute walk test mwt materials methods consecutive patients confirmed diagnosis ild taken period year tertiary care hospital mwt spirometry performed per american thoracic guidelines percent predicted minute walk distance calculated using enright indian reference equation diagnosed using echo spirometry variables mwt correlated mean pulmonary artery pressure results patients echo mean predicted six minute walk distance per indian reference equation pre post exercise pao well desaturation significant correlation spirometry variables forced expiratory volume first second fev forced vital capacity fvc correlate conclusion thus mwt correlated significantly spirometry
aims anti inflammatory effects polyphenol resveratrol patients type diabetes mellitus tdm controversial role pentraxin ptx concentrations human acute phase protein never evaluated aim determine whether two dosage resveratrol supplementation day impact ptx values tdm patients double blind randomized placebo controlled trial variations total antioxidant status tas evaluated methods total tdm patients randomized receive resveratrol day resv arm resveratrol day resv arm placebo months baseline trial end ptx tas values determined results dose dependent increase ptx concentrations resv arm resv arm reduction placebo found adjusted mean differences change versus placebo resv resv arms respectively subgroup analyses lower diabetes duration aspirin alcohol use younger age female gender smoking resv arm female gender aspirin use resv arm associated higher ptx increments dose dependent increment tas values resveratrol arms resv resv respectively reduction placebo arm observed adjusted mean differences change resv resv arms respectively conclusion resveratrol supplementation increased ptx tas levels dose dependent manner tdm patients present potential clinical implications results remain unclear
chemotaxis microorganisms autonomous motility along concentration gradients chemical species important yet often neglected factor controlling transport bacteria saturated porous media example chemotactic bacteria could enhance bioremediation directing motion residual contaminants trapped low hydraulic conductive zones contaminated aquifers aim present work develop accurate numerical scheme model chemotaxis saturated porous media advective dominating flow systems propose model chemotaxis using new class meshless lagrangian particle methods recently developed applications fluid mechanics method based smooth particle hydrodynamics sph formulation ben moussa int ser numer math combined new weighted essentially non oscillatory weno reconstruction technique moving point clouds multiple space dimensions purpose new numerical scheme fully exploit advantages sph among traditional mesh based mesh free schemes overcome drawbacks related use standard sph modeling chemotaxis porous media first test new scheme analytical reference solutions assumption complete mixing darcy scale perform two dimensional conservative solute transport simulations steady state flow conditions show capability proposed new scheme model chemotaxis
geo fencing predicted multi billion dollar market areas retail ambient intelligence entertainment healthcare etc businesses adopting geo fencing technology several platform providers google qualcomm esri urban airship others tools continuing attract application developers however best practices choosing specific performance options within technology still ambiguous example esri provides geo trigger service allows developers send targeted messages users enter exit dwell geo fenced area service also provides ability choose higher levels accuracy battery saving offering different location tracking profiles paper investigated two geo trigger tracking profiles fine adaptive assess performance small outdoor geo fenced areas two profiles accurate vary battery use results show adaptive tracking profile provide reliability average accuracy meters geo fences meter radii addition adaptive tracking profile saved battery life user stationery user moving published elsevier ltd
ultrasound thermometry based measuring tissue temperature impact ultrasound wave propagation study focuses use transducer array channel data beamformed examines layer increased velocity heat induced affects travel times ultrasound backscatter signal based geometric considerations new equation derived change time delay function temperature change resulting expression provides insight key factors link change temperature change travel time shows velocity enters combination heating geometry complementary information needed compute velocity changes travel time using bio heat equation second source information derived expressions feasibility monitoring temperature increase cardiac ablation therapy using channel data investigated intra cardiac ice probe using time delay error approach would feasible trans esophageal array transducer tee transducer might feasible elsevier rights reserved
green village campus delft university technology autarkic water circuit developed aim avoid connections public water supply system sewerage electricity grid cable systems produce drinking water electricity clean organic waste streams sustainable way due strict dutch drinking water regulations one water quality supplied drinking water drinking water produced greywater supplemented rainwater treatment scheme multiple barrier approach used comply dutch drinking water quality standards greywater treatment triple barrier suggested ozonation ultrafiltration disinfection rainwater treatment dual barrier suggested ultrafiltration disinfection separating wastewater streams point origin greywater blackwater replacing conventional toilets low water consumption vacuum systems part water conservation measures possible collect concentrated blackwater stream suitable recovery energy purpose upflow anaerobic sludge blanket reactor suggested proposed water circuit results autarkic water management autarkic energy management
according cognitive theories personality disorders antisocial personality disorder aspd based upon distinct set cognitive behavioral representations aim study examine supposition comparing early maladaptive schemas emss core beliefs young antisocial men set socio demographically matched psychiatrically healthy individuals used schema questionnaire social comparison scale scs identify evaluate subjects emss core beliefs thirty eight antisocial individuals healthy control subjects participated study results scs indicated antisocial patients see unlovable lonely rejected results indicated antisocial patients significantly elevated clinically relevant scores comparison controls following areas emotional deprivation entitlement grandiosity mistrust abuse vulnerability harm illness social isolation general results present study tentatively indicate aspd individuals demonstrate common profile core beliefs unique individuals diagnosed aspd implications findings discussed cognitive behavioral theory treatment aspd
ambient intelligence emerging platform provides advances sensors sensor networks pervasive computing artificial intelligence capture real time climate data result continuously generates several exabytes unstructured sensor data often called big climate data nowadays researchers trying use big climate data monitor predict climate change possible diseases traditional data processing techniques tools capable handling huge amount climate data hence need develop advanced big data architecture processing real time climate data purpose paper propose big data based surveillance system analyzes spatial climate big data performs continuous monitoring correlation climate change dengue proposed disease surveillance system implemented help apache hadoop mapreduce supporting tools
work fractional differential equation electrical rlc circuit studied order derivative considered gamma parts per thousand currency sign keep dimensionality physical quantities auxiliary parameter gamma introduced parameter characterizes existence fractional components system shown relation sigma physical parameters rlc circuit due relation analytical solution given terms mittag leffler function depending order fractional differential equation
soil heavy metal pollution driving force various health problems well reprehensible soil quality landfill leachates one focal sources soil underground water pollution total number soil samples taken three different soil horizons tested heavy metal content physical chemical properties measured approximately leachates released main local stream pour area used agriculture practices olive cultivation designated area located municipality thermi prefecture thessaloniki greece total extractable concentrations seven different heavy metals detected using atomic absorption spectroscopy elucidated slightly average universal allowable concentrations inverse distance weighting interpolator implemented weighted linear combination used assess overall pollution risk different multivariate analyses implemented point relationship experimented heavy metals risk soil heavy metal pollution tagarades incontestable nevertheless underground water tagarades meantime jeopardy underground water pollution threat constantly exists
objectiveprior research suggests body mass index bmi weight suppression highest past weight minus current weight important determining adult anorexia nervosa severity examined associations amenorrhea dsm bmi severity category highest premorbid bmi among patients methodparticipants adult female spectrum patients two residential treatment facilities admission height weight measured participants completed questionnaires assessing menstrual status weight history resultsgreater adjusted bmi associated menstrual function admission first amenorrhea onset occurred normal bmi participants premorbid highest bmi positively correlated bmi amenorrhea onset higher bmi amenorrhea onset associated higher bmi menses resumption discussionthese findings add literature indicating relative absolute weight status dual indicators illness severity preliminarily suggest large proportion adults present treatment initially may shown symptoms starvation normal bmi results underscore need focus weight loss early detection efforts may inform target weight setting treatment
performance bounds maximum likelihood decoding convolutional codes memoryless channels commonly measured using distance weight enumerator also referred transfer function code paper presents efficient iterative method obtain called state reduction algorithm algorithm systematic technique simplify signal flow graphs algebraically manipulate symbolic adjacency matrix associated convolutional code next algorithm modified compute first terms series expansion partial derivativet partial derivativex distance spectra without first computing complete
water shortages widely prevalent developing countries affecting lives people including schoolchildren miss classes fetching water daily use typical case mnyundo primary school tanzania east africa rainwater harvesting rwh system constructed easy adaptability technology purpose study sustainability evaluation evaluation considered construction details level water supply service potential sustainability replication coarse screen first flush tank sedimentation tank included maintaining drinkable water quality particle load reduction water level gauge incorporated enables easy monitoring water usage provided training operational manual practical guide system management users local labor material techniques used recommended capacity building sense ownership cost reduction companies involvement encouraged providing financial support schools corporate social responsibility rwh thus suggested sustainable alternative drinking water supply
parking information release large flow released information timely accurately order solve problems global internet things stereoscopic parking system proposed based timer control parking information system use core technology internet things combination timer elastic pressure switch pressure sensor using electrical circuit realize parking information acquisition storage release reliable accurately experimental result shows electrical circuits better accurately obtained parking information car user uses vehicle terminal search target parking lot receive parking information future gradually extended smart phone board navigator system system alleviate urban traffic improve utilization efficiency urban parking lot future city social development provide better technical support basis
study investigates effect temporary aid needy families tanf program children health outcomes using data survey income program participation period tanf policies credited increased employment single mothers dramatic drop welfare caseload results show policies also significant effect various measures children medical utilization among low income families health measures include rating child health status reported parents number times parents consulted doctor number nights child stayed hospital compare overall changes health status medical utilization children working nonworking mothers find child health status reported parents affected maternal employment status copyright john wiley sons ltd
research internal model based method proposed estimate structural displacements velocities ambient excitation using acceleration measurements structural response assumed within linear range excitation assumed zero mean relatively broad bandwidth least one fundamental modes structure excited dominates response using structural modal parameters partial knowledge bandwidth excitation internal models structure excitation respectively established used form autonomous state space representation system shown structural displacements velocities accelerations states system fully observable measured output contains structural accelerations reliable estimates structural displacements velocities obtained using standard kalman filtering technique effectiveness robustness proposed method demonstrated evaluated via numerical simulations eight story lumped mass model experimental data three story frame excited ground accelerations actual earthquake records
major histocompatibility complex mhc class chain related mica polymorphic non classical mhc class gene humans encodes ligand nkgd group member activating natural killer receptor expressed mainly cells cells single nucleotide polymorphism snp causing valine val methionine met exchange position mica protein specific interest separates mica isoforms bind nkgd high met low affinities val therefore snp investigated associations infections autoimmune diseases cancer systematically review studies analyze view new data functional consequences polymorphism shown recently mica met variant elicits stronger nkgd signaling resulting degranulation ifn gamma production cells faster costimulation cells mica val variant however mica met isoform also downregulates nkgd efficiently mica val isoform downregulation impairs nkgd mediated functions high expression intensities mica met variant features mica met val dimorphism need considered interpreting disease association studies particularly field hematopoietic stem cell transplantation help explain associations snp outcome including graft versus host disease relapse malignancy implications future disease association studies mica met val dimorphism discussed
mceliece goldreich goldwasser halevi ggh cryptosystems two instances code lattice based cryptosystems whose security based hardness coding theoretic lattice problems respectively however cryptosystems number drawbacks make inefficient practice hand low density lattice codes ldlcs practical lattice codes achieve capacity additive white gaussian noise channel also encoded decoded efficiently paper introduces public key cryptosystem based latin square ldlcs relationship attained code lattice based cryptography way exploit efficient properties codes lattices simultaneously improve security efficiency proposed scheme instance security scheme based hard problems related lattices closest vector problem shortest basis problem turn lead increase security level hand exploit low complexity decoding algorithm ldlcs reduce computational complexity moreover property allows using larger values codeword length also use special gaussian vector whose variance upper bounded poltyrev bound perturbation error vector strategies make proposed scheme secure conventional cryptanalytic attacks
hypothesized distinct acute right hemisphere lesions disrupt separate components valuation emotional response winning losing money emotional empathy observing partner win lose money measured skin conductance response scr ratings emotions acute right hemisphere stroke patients healthy controls lost money roulette watched partner win lose results showed percentage damage stroke right anterior insula frontal operculum negatively correlated scr winning losing difference rating wins versus losses
introduction obesity represents major public health problem associated medical psychological impairment obesity frequently studied binge eating disorder bed comorbidity less evidence available non bed obesity spite correlation psychological impairment body image disturbance study explored psychopathological features eating behaviors body image disturbance self identity impairment patients obesity control group patients also studied relation specific eating body features psychopathological symptoms finally explored latent factorial structure describes features material methods clinical sample composed twenty patients suffering obesity without bed females control group included twenty eight healthy normal weight subjects females enrolled general population participants underwent clinical interview filled questionnaires body image psychopathological symptoms statistics student test applied compare obese patients healthy controls psychological dimensions clinical sample gender differences tested multivariate analyses variance manova correlational analyses explored relation specific eating body features psychopathological symptoms lastly principal components factor analysis performed explore existence latent factorial structure emerging assessment evaluation obese population results obese patients reported significantly higher scores healthy controls several psychopathological dimensions somatization obsessive compulsive depression hostility phobic anxiety psychoticism patients also reported higher body uneasiness self identity impairment resulting scores body uneasiness test identity eating disorders questionnaire avoidant behaviours frequently reported men whereas women reported higher body distress dissatisfaction clinical sample questionnaires correlated three factor structure emerged weight body control weakness self identity psychopathological distress discussion present study found obese patients might present several disturbances body image self perception general psychopathological distress clinicians aware issues improve therapeutic strategy treatment obesity
estimation space time dependent earthquake probabilities including aftershock sequences received increased attention recent years operational earthquake forecasting systems currently implemented various countries physics based earthquake forecasting models compute time dependent earthquake rates based coulomb stress changes coupled seismicity evolution laws derived rate state friction early implementations models typically performed poorly compared statistical models recent studies indicate significant performance improvements achieved considering spatial heterogeneity stress field secondary sources stress however major drawback methods rapid increase computational costs present code calculate seismicity induced time dependent stress changes important feature code possibility include aleatoric uncertainties due existence multiple receiver faults finite grid size well epistemic uncertainties due choice input slip model compensate growth computational requirements parallelized code shared memory systems using openmp distributed memory systems using mpi performance tests indicate parallelization strategies lead significant speedup problems different degrees complexity ranging solved standard multicore desktop computers requiring small cluster large simulation run using cores elsevier ltd rights reserved
elastic optical networks eons play important role next generation core networks especially supporting cloud computing however network traffic growing exponentially almost reached physical capacity limit single mode fibers space division multiplexing sdm potentially employed increase fiber capacity multi core fibers mcfs make use sdm aggregate multiple cores together cladding one fiber greatly increase capacity eons incurs new crosstalk constraints anycast flexible compared unicast anycast communications widely used cloud computing distributed computing distributed storage system content delivery networks letter formulates anycast planning problem sdm eons mcfs evaluation results show cvx gurobi tools solve small size problems scale well therefore propose heuristic algorithm efficiently solve problem best knowledge first work considers ancyast routing sdm eons mcfs
background fxii dependent kallikrein kinin system kks tightly regulated serine protease inhibitor serpin inhibitor inh regulation fxii dependent mks fails case hereditary angioedema hae patients consequently experience invalidating edema attacks hae caused mutations inh encoding gene recently demonstrated mutations give rise presence polymerized inh plasma hae patients methods inh polymers corresponding size polymers observed vivo produced using heat denaturation gel filtration ability polymers facilitate fxii activation assessed vitro fxii activation bandshift assay spiking plasma inh polymers kallikrein generation analyzed global kallikrein generation method prekallikrein consumption entire danish hae cohort analyzed using elisa method results inh polymers mediated fxii activation dose dependent kallikrein generation plasma spiked inh polymers increased pre kallikrein consumption observed plasma samples hae patients presenting inh polymers vivo conclusion polymerization inh transforms major inhibitor fxii dependent kks potent activator system general significance inh polymers might play role pathophysiology hae several diseases characterized presence serpin polymers role serpin polymers far remained elusive results indicate polymers play role inflammatory mediators fxii dependent kks elsevier rights reserved
magnetic moment magnetically labeled cells microbubbles microspheres important optimization parameter many targeting delivery separation applications quantification property often difficult since depends type incorporated nanoparticle also intake capabilities surface properties internal distribution describe method determine magnetic moment carriers using microscopic set image processing algorithm contrast works measure diversion superparamagnetic nanoparticles static fluid set optimized achieve homogeneous movement magnetic carriers inside magnetic field evaluation automated customized algorithm utilizing set basic algorithms including blob recognition feature based shape recognition graph algorithm present example measurements characteristic properties different types carriers combination different types nanoparticles properties include velocity magnetic field well magnetic moment investigated carriers adherent suspension cells used nanoparticles different sizes coatings obtain varying behavior carriers
aims objectives investigate prevalence breast related stereotype threat effects symptom cluster consisting anxiety depression fatigue symptom background stereotype breasts sign women femininity results patients breast cancer fearing diminished femininity rejection may induce psychological problems occur symptom cluster design cross sectional study methods total patients breast cancer postmastectomy completed study question measuring breast related stereotype threat hospital anxiety depression scale functional assessment chronic illness therapy fatigue scale used assess breast related stereotype threat symptoms anxiety depression fatigue results patients answered breast related stereotype threat question reported breast related stereotype threat differ significantly social clinical characteristics compared without stereotype report significantly higher levels symptom cluster symptom anxiety depression fatigue odds ratios stereotype significant symptom cluster depression fatigue odds ratios conclusion breast related stereotype threat common patients breast cancer twofold increase risk experiencing symptom cluster symptoms depression fatigue relevance clinical practice clinical practice breast related stereotype threat measured together prevalent symptoms anxiety depression fatigue patients breast cancer findings aid development interventions improving mental health women breast cancer
mesenchymal stem cells mscs multipotent stromal cells immunomodulatory properties emerged promising treatment autoimmunity inflammatory diseases rheumatoid arthritis previous studies demonstrated mscs administered systemically migrate lymphoid tissues associated inflammatory site functional msc induced immune cells regulatory phenotype increased mediating immunomodulatory effects mscs results suggest homing mscs lymphatic system plays important role mechanism action mscs invivo thus hypothesized direct intralymphatic also referred intranodal administration mscs could alternative effective route administration msc based therapy report feasibility efficacy administration human expanded adipose mesenchymal stem cells eascs mouse model collagen induced arthritis cia administration eascs attenuated severity progression arthritis reduced bone destruction increased levels regulatory cells foxp cells cells spleen draining lymph nodes taken together results indicate administration eascs effective modulating established cia may represent alternative treatment modality cell therapy eascs
substance use complex clinical problem characterized emotion dysregulation daily challenges interfere laboratory research thus psychophysiological studies examine autonomic self report measures emotion dysregulation multidiagnostic chemically dependent samples extend work naturalistic settings study used within subject design examine changes respiratory sinus arrhythmia rsa electrodermal activity eda self reported affect across three tasks designed elicit distinct psychophysiological emotional response patterns also examined emotion dysregulation moderator psychophysiological responses participants include women multiple comorbid mental health conditions enrolled substance use treatment many also reported high emotion dysregulation participants assessed treatment setting completed three tasks watching sad movie clip rumination stressful event mindful interoceptive awareness meditation multilevel models used examine changes resting baselines tasks film results indicate significant decrease rsa increase eda rumination task participants showed decrease rsa eda response body awareness task increase rsa decrease eda emotion dysregulation associated differences baseline rsa eda slope response patterns across tasks self reported affect largely consistent autonomic patterns findings add literature emotion dysregulation substance use translation psychophysiological measurements clinical settings complex samples
describe variability rheumatology visits referrals medical specialties patients spondyloarthritis spa explore factors may influence variability nation wide cross sectional study performed randomly selected records patients diagnosis spa least one visit rheumatology unit within previous years audited rates rheumatology visits referrals medical specialties estimated total centres study period multilevel regression used analyse factors associated variability adjust clinical patient characteristics patients records centres reviewed mainly ankylosing spondylitis psoriatic arthritis patients incurred visits rheumatology clinics rate per patient years visits medical specialties referrals rheumatology visits specialised nurse clinics adjusted variability frequenting rheumatology clinics centres observed partially explained number faculties trainees adjusted intercentre variability referrals specialties associated urban settings number procedures existence spa dedicated clinics probability patient spa referred specialist may increase depending treating centre frequenting rheumatology clinics referrals specialists significantly varies centres adjustment patient characteristics
aim investigation study performance twin entry turbine pulsed flow conditions ansys cfx code used solve three dimensional compressible turbulent flow equations computational results compared one dimensional model experimental data good agreement found
miniature thermoacoustic stirling engine simulated designed overall size length height acoustic field generated miniature system described analyzed efforts paid coupling matching miniature thermoacoustic engine extra experimental components constructed analysis experimental results showed obtain better performance engine diameter resonance tube must chosen appropriately according looped tube dimension input heating power provided effective way miniaturize thermoacoustic stirling heat engine experimental results showed engine low onset temperature high pressure amplitude ratio filling helium gas mpa heating power maximal peak peak pressure amplitude pressure ratio reached bar respectively able drive refrigerator heat pump linear electrical generator operating frequency engine steady elsevier ltd rights reserved
article load settlement characteristics unreinforced reinforced two layered soil loading process investigated series bearing ratio tests performed granular soil base layer overlaying cohesive soil subgrade layer three reinforcing conditions unreinforced reinforced nonwoven geotextile reinforced geogrid interface layers four compaction moisture contents cmcs subgrade layer three thicknesses base layer soaked non soaked conditions considered results show cmc subgrade layer significant effect behavior two layered soil swelling amount efficiency reinforcements reinforcing geogrid resulted considerable increase strength soaked samples due adhesion geogrids clayey subgrade layer nonwoven geotextiles strength two layered soil decreased shallow penetration depths due reinforcements penetration increased depth strength also increased also found decreases base layer thickness test variable value cmc type geosynthetic reinforcement significant effects behavior two layered soil
paper consider multi way relay system network coding multi spot beam satellite networks particular focus multiparty video conferencing via satellite proposed protocol uses multicasting routing information number video frame packets generate coded packets proposed protocol ensures reliable transmission multicasting data mobile users using decoding error rate random linear network coding batch minimize delay link layer propose resource allocation scheme multiparty video conferencing satellite communications resource allocation use application information acquired performance enhancing proxy simulation results show achievable rate increased proposed protocol proposed protocol also reduce number packet transmissions resulting efficient usage satellite radio resources furthermore shown proposed protocol ensures reliable transmission multicasting data mobile users using resources saved average peak signal noise video streaming mobile users better conventional system result visual quality video streaming services improved
several studies suggest invertebrate abundance richness disrupted reset confluences thus junctions contribute disproportionately overall aquatic biodiversity river general terms authors reported high abundance diversity due major physical heterogeneity junctions however data still scarce uncertainties plentiful impact great input fine sediments distribution patterns benthic invertebrates river confluence quantitatively analyzed herein junction subtropical bermejo river high suspended sediment load large paraguay river selected study area achieve aim diversity increased slightly downstream junction density richness macroinvertebrate assemblage significantly diminished downstream confluence ind due input fine sediment bermejo river mean fine sediment increased downstream causing negatively impact invertebrate assemblage study highlights ecological importance sediment input effects benthic invertebrates topic still poorly explored river ecology speculated spatial extent impact would dependent upon hydrological sedimentological context highly unequal rivers new hypotheses tested new studies considering different hydrological stages
present thermodynamic model heat conductor allows different temperatures phonons electrons model applied calculate steady state radial temperature profile circular thin layer compatibility obtained temperature profiles second law thermodynamics investigated view requirement positive entropy production nonlocal constitutive equation entropy flux
software project scheduling dynamic uncertain environments significant importance real world software development yet studies schedule software projects considering static deterministic scenarios may cause performance deterioration even infeasibility facing disruptions order capture dynamic features software project scheduling previous work paper formulates project scheduling problem considering uncertainties dynamic events often occur software project development constructs mathematical model resulting multi objective dynamic project scheduling problem modpsp four objectives project cost duration robustness stability considered simultaneously variety practical constraints order solve modpsp appropriately multi objective evolutionary algorithm based proactive rescheduling method proposed generates robust schedule predictively adapts previous schedule response critical dynamic events project execution extensive experimental results problem instances including three instances derived real world software projects show novel method effective introducing robustness stability objectives incorporating dynamic optimization strategies specifically designed modpsp proactive rescheduling method achieves good overall performance dynamic environment
dominant pole placement useful technique designed deal problem controlling high order time delay systems low order controller pid controller paper tries solve problem using decomposition method straightforward analytic procedure makes method extremely powerful easy apply technique applicable wide range transfer functions without time delay rational non rational ones describing distributed parameter systems order control many different processes possible fractional order pid controller introduced generalization classical pid controller consequence provides additional parameters better adjusting system performances design method presented paper tunes parameters pid fractional pid controller order obtain good load disturbance response constraint maximum sensitivity sensitivity noise measurement good set point response also one design goals technique numerous examples taken process industry given decomposition approach compared pid optimization methods show effectiveness isa published elsevier ltd rights reserved
paper reviews studies conducted performance american football helmet preventing concussion review also guide understand problems still exist research directions take throughout history sports injuries limiting career life athletes leading concern sport authorities injuries extensive sports athletes severe contact mild traumatic brain injury concussion widely occurs american football frequent strokes players heads concussion includes several types neurological dysfunctions headache dizziness confusion blurred vision delayed reaction time etc lots studies focused understanding concussion improving protective performance helmet dose injury players reduced researches area classified two major methods experimental studies finite element modeling fem simulations experiments researchers tried torecord head impacts reconstruct severe collisions using game videos laboratory conditions used hybrid iii dummy order study effects different impact parameters direction velocity region head hit etc studies done analyzing dynamic responses head includinglinear acceleration rotational acceleration different head injury criteria like head injury criteria hic gadd severity index gsi mentioned impact parameters also examined using fem simulations researchers applied results experimental tests including linear rotational acceleration order study brain deformation responses different types impacts regards brain deformation responses like maximum principal strain considered analyzed using head injury concussion thresholds authors published elsevier open access article license
understanding basic concepts electronics computer programming allows researchers get equipment found laboratories although number platforms specifically designed general public supported vast array line tutorials subject normally included university chemistry curricula aiming provide basic concepts hardware software article focused design use simple module control series pdms based valves module based low cost microprocessor teensy open source software arduino microvalves fabricated using thin sheets pdms patterned using laser engraving providing simple efficient way fabricate devices without traditional photolithographic process facilities synchronization valve control enabled development two simple devices perform injection stroke mixing different solutions furthermore practical demonstration utility system microscale chemical sample handling analysis achieved performing chip acid base titration followed conductivity detection open source low cost detection system overall system provided reproducible platform perform fluid delivery microfluidic scale
conducted systematic literature review identify critically evaluate studies serious adverse health effects sahes humans using nicotine replacement therapy nrt products serious adverse health effects refer adverse events leading substantial disruption ability conduct normal life functions strength evidence evaluations conclusions also determined identified sahes evaluated epidemiological studies clinical trials relating nrt use cancer reproduction development cvd stroke sahes patients four meta analyses effects healthy populations overall evidence suffers many limitations significant short term exposure weeks follow nrt product use studies common failure account changes smoking behaviour following nrt use sparse information sahes type nrt product used sahe nrt exposure identified increase respiratory congenital abnormalities reported one study limited evidence indicated lack effect nrt exposure sahes cvd various reproduction developmental endpoints cancer stroke sahes evidence inadequate demonstrate association nrt use conclusions agree recent statements authoritative bodies
typical smart grid large number smart meters deployed energy consumers premises report real time usage data control center energy producer although communication model help improve efficiency reliability electricity delivery crucial society also leads several security issues attackers may violate privacy energy consumers attackers may tamper transmitted data benefits purposes deal security issues many researchers proposed different schemes privacy preservation abnormal data detection however existing studies usually address separately paper jointly resolve two major security issues smart grid specifically propose privacy aware data dissemination scheme smart grid abnormal data traceability pdds based bilinear group theory non interactive zero knowledge proof scheme design novel link function verify whether different signatures signed consumer effectively reduces time communication overhead tracing evaluate correctness performance proposed scheme first develop solid security analysis shows proposed scheme efficiently preserve identity confidentiality data integrity conduct extensive simulation experiments demonstrate scheme significantly reduce communication costs elsevier rights reserved
bone remarkable living material comes two forms different porosities different macrostructure highly organised microstructure nanostructure bone accumulates damage removed replaced mechanical demands bone increase bone mass increases reductions loading leads removal bone thus bone considered smart material ongoing replacement old bone tissue new bone tissue called remodelling bone formation repair remodelling controlled produced four types cell namely osteoblasts osteoclasts osteocytes bone lining cells bone remodelling regulated signals cells generated mechanical loading exactly loads transferred bone bone cells sense loads signals translated bone formation removal unknown review structure bone cells responsible maintaining bone described mechanisms cause bone adapt mechanical loading investigated methods employed attempts determine mechanism considered
paper present mathematical knot braid diagram interface exploits computer graphics interactive visualization multi touch technology enhance one intuitive experience mathematical theory knots interaction model based clever simple geometric construction named reide meister moves allows topological manipulations using rather simple moves multi touch interfaces provide natural way interact extra degrees freedom characterize knots mathematical physical arithmetic properties relative specialized mouse driven interface proposed multi touch interface easier intuitive learn pilot study shows knot braid manipulation multi touch much faster efficient combine show interactive computer graphics methods computer interfaces used construct virtual manipulatives meet challenge exploring abstract mathematical worlds
background temporo mandibular joint tmj replacement used clinically years objective study evaluate outcomes achieved patients two different categories tmj prostheses material methods patients tmj replacement tmjr implanted study period included year prospective study procedures performed using biomet microfixation tmj replacement system involved replacing skull base component glenoid fossa mandibular condyle results fifty seven patients females males involving tmjs severe disease requiring reconstruction unilateral bilateral operated consecutively stock prostheses custom made prostheses implanted mean age surgery years stock group years custom made group stock group three years tmjr results showed reduction pain intensity improvement jaw opening custom made group three years tmjr results showed reduction pain intensity improvement jaw opening statistically significant differences two groups detected conclusions results three year prospective study support surgical placement tmj prostheses stock prosthetic custom made systems show approach efficacious safe reduces pain improves maximum mouth opening movement complications tmjr represents viable technique stable long term solution cranio mandibular reconstruction patients irreversible end stage tmj disease comparing stock custom made groups statistically significant differences detected respect pain intensity reduction maximum mouth opening improvement
object segmentation aims simultaneously segment common regions interest multiple images great importance image classification object recognition image retrieval one way extract similar objects shared multiple images construct correlation function image regions paper object segmentation addressed based weakly supervised data fusion first integrate image boundary information weakly supervised clustering adopting efficient image segmentation algorithm proved convergence feature learning well clustering also incorporated proposed algorithm establish unified framework optimal feature subspace clustering oriented methods provided second shared object multiple images regarded procedure search objects heterogeneous data sources formalized data fusion problems using data fusion techniques present novel method evaluate similarity images facilitates use similar objects multiple images finally two proposed object segmentation segmentation algorithms verified publicly available datasets msra icoseg experiments demonstrate algorithms capable achieve superior comparable performance compared state art segmentation methods tested datasets published elsevier inc
present petiga code framework approximate solution partial differential equations using isogeometric analysis petiga used assemble matrices vectors come galerkin weak form discretized non uniform rational spline basis functions base framework petsc high performance library scalable solution partial differential equations simplifies development large scale scientific codes provides rich environment prototyping separates parallelism algorithm choice describe implementation petiga exemplify use solving model nonlinear problem illustrate robustness flexibility petiga solve challenging nonlinear partial differential equations include problems solid fluid mechanics show strong scaling results cores confirm suitability petiga large scale simulations elsevier rights reserved
processes human resources formation development among topical areas research growth national economies china like developing countries building innovation economy considers national human capital key factor growth china greatest amount human resources among countries world largely ensures success global economy however birth control policy factors led emergence several issues may significant impact formation human capital economic growth country purpose present study reveal modern trends formation human resources china considering demographic urban economic aspects paper defines concept national human resources substantiates urgency comprehensive research accumulation human potential populous country china authors consider population dynamics china including able bodied population analyze age structure population level dependency level urbanization specifics spatial distribution population particular emphasis placed problem reduction share working age population assessment role internal migration flows formation human capital cities assessment total economic effect urbanization analysis uneven spatial distribution human resources china impact volume production regions several key indicators presented context major chinese cities provinces
objective current study aimed examine counselors nonverbal communication nonverbal encouragements counselee directed eye gaze conversational contribution verbal dominance interactivity final visit within breast cancer genetic counseling relate counselee satisfaction needs fulfillment anxiety methods breast cancer counselees completed questionnaires measuring satisfaction needs fulfillment anxiety final consultation anxiety initial visit consultations videotaped counselor nonverbal encouragements counselee directed eye gaze coded verbal dominance interactivity measured using roter interaction analysis system rias results counselor nonverbal encouragements higher counselor verbal dominance significantly related higher post visit anxiety furthermore counselor verbal dominance associated lower perceived needs fulfillment significant associations eye gaze interactivity found conclusion research needed relationship nonverbal encouragements anxiety given unfavorable association counselor verbal dominance anxiety needs fulfillment effort could devoted involve counselees dialog reduce counselor verbal contribution consultation practice implications interventions focused increasing counselees contribution consultation may beneficial counselees elsevier ireland ltd rights reserved
two dimensional grain structure polycrystalline foil pure copper studied ebsd compared model polycrystal random grain orientations texture withcrystallographic direction preferentially oriented perpendicular foil surface observed sigma sigma sigma grain boundaries gbs frequent experimental dataset simulated random one planes frequently observed similar enrichment planes obtained simulated set gbs texture foil planes orientation taken account elsevier rights reserved
background many patients dizziness complain type dizziness therefore may coexisting diagnoses objective determine often second third diagnosis present patient dizziness establish common combinations diagnoses study design prospective observational study tertiary center results consecutive cohort patients included study patients second diagnosis present within group third diagnosis present patients common second diagnosis anxiety disorder conclusions patients dizziness frequently present type dizziness caused different diseases study patients dizziness diagnosis anxiety disorder common second diagnosis
work investigates influence electrical circuits tmf total thermoelectromotive force response signals captured rotating workpiece generated tool workpiece thermocouple system turning process considering four different thermoelectrical circuits namely bronze pin aluminum pin graphite brush liquid mercury contact tests carried different cutting conditions multifactorial analysis variance performed using factorial design always considering lower level addition single factor analysis variance performed keeping cutting speed feed rate depth cut doc lubri coolant system lub constants varying order validate results found factorial design results indicated statistical significant difference tmf responses tool workpiece thermocouples well however comparing tmf generated significant difference detected indicating graphite brushes recommended application bronze aluminum pins thought advantageous substitute laborious liquid mercury system elsevier ltd rights reserved
popularity smartphones usage especially android mobile platform increased share global smartphone operating systems market result top attacker target list fact private data low security assurance letting attacker write several malware programs different ways smartphone possibility obfuscating malware detection applications different coding techniques giving energy attacker several approaches proposed detect malwares code analysis severely facing problem code obfuscation high computation requirement propose machine learning based method detect android malware analyzing visual representation binary formatted apk file grayscale rgb cmyk hsl gist feature malware benign image dataset extracted used train machine learning algorithms initial experimental results encouraging computationally effective among machine learning algorithms random forest achieved highest accuracy grayscale image improved tuning various parameters
paper presents novel circuit design input output rail rail cmos second generation current conveyor ccii low voltage low power applications designed circuit structured single stage rail rail operational amplifier amp conventional cmos inverter class amplifier therefore provides high wide range input signal high output current driving capability operation paper new technique automated design script created produce constant trans conductance rail rail amp using open command environment ocean script language proposed rail rail amp based level shifter technique cited input stage script allows design problem cast program therefore offers efficient reliable fast way implement high performance analog integrated circuits moreover physics based characteristic used suitable short channel transistors sub micron processes circuit simulated ibm cmos technology single power supply virtuoso layout editor tool caliber tools mentor graphics used carry layout proposed circuit chip fabricated mosis educational program mep tested evaluate performance proposed circuits measured simulation results indicate good agreement elsevier ltd rights reserved
decade old theory hypothesizes brain exposure androgens promotes involvement criminal behavior general support hypothesis provided studies postpubertal circulating levels testosterone least among males however theory also predicts genders prenatal androgens positively correlated persistent offending idea evidence currently exists present study used indirect measure prenatal androgen exposurethe relative length second fourth fingers right hand test hypothesis elevated prenatal androgens promote criminal tendencies later life males females questionnaires administered college students malaysia college students united states respondents reported relative finger lengths along involvement categories delinquent criminal acts statistically significant correlations commission types offenses ratios found males females even controlling age concluded high exposure androgens prenatal development contributes forms offending following onset puberty
effective data structure regards fast data changing one important demands spatio temporal data spatio temporal data special relationships regard spatial temporal values types data complex terms numerous attributes changes exhibited time data model able increase performance data storage inquiry responses spatio temporal system demanded structure relationships spatio temporal data mimics biological structure hair root spatial values shaft temporal values undergoes growth paper aims show mathematical formulation hair oriented data model hodm spatio temporal data demonstrate model performance measuring storage size query response time experiment conducted using records climate change spatio temporal data implemented implemented object relational database using nested tables data structure operations implemented sql statements related concepts object relational databases performances file storage execution query compared using tabular normalized entity relationship model engages various types queries results show hodm lower storage size faster query response time studied types spatio temporal queries significances work elaborated comparison generic data models experimental results showed proposed data model easier develop efficient elsevier ltd rights reserved
human pose estimation single image important problem computer vision number applications including action recognition scene understanding however still challenging due ill posedness complex non rigid shape variations human body paper use procrustean normal distribution mixture model shape prior propose model transformation method adjusting limb lengths shape prior model proposed method applied novel test image inaccuracies part detections handled selecting diverse set pose candidates considering part model shape model experimental results show proposed method performs favorably compared existing methods despite inaccuracies part detections shape ambiguities elsevier inc rights reserved
nosql graph databases introduced recent years dealing large collections graph based data scientific data social networks among best examples dramatic increase use structures nosql repositories allow management large amounts data order store query data structured predefined schema relational databases could rather composed nodes relationships certain type instance node represent person relationship friendship retrieving structure graph database thus great help users example must know query data identify relevant data sources recommender systems reason paper introduces methods retrieve structural summaries structural summaries extracted different levels information nosql graph database expression mining queries facilitated use two frameworks fuzzys allowing define fuzzy operators operations scala cypherf allowing use fuzzy operators operations declarative queries nosql graph databases show extracting summaries impossible nosql query engines data volume complexity task automatic knowledge extraction novel method based memory architectures thus introduced paper provides definitions summaries methods automatically extract nosql graph databases help memory architectures benefit proposition demonstrated experimental results
background recent studies compared efficacy cognitive intervention compared behavioral techniques treatment different disorders line work empirical study presented examined efficacy behavioral activation cognitive therapy negative automatic thoughts pans elicited situations generating anxiety method based sample students aged took isra bads eros subjects highest scores selected assigned random one two experimental groups control group experimental group given intervention based experimental group based interventions consisted five min sessions results pre post treatment measurement analyses reveal conditions effectively reduced intensity anxiety response however condition showing significant reduction ants conclusions results discussed stressing efficacy exclusively cognitive intervention
background chronic ankle instability cai disabling condition often encountered ankle injury three main components cai exist perceived instability mechanical instability increased ankle ligament laxity recurrent sprain literature evaluating cai heavily focused adults little attention cai children hence objective study systematically review prevalence cai children methods studies retrieved major databases earliest records march references identified articles also examined studies involving participants cai classified authors children considered inclusion papers investigating traumatic instability instability arising fractures excluded two independent examiners undertook stages screening data extraction methodological quality assessments screening discrepancies resolved reaching consensus results following removal duplicates papers screened eligibility inclusion exclusion criteria nine full papers included review symptoms cai evaluated included perceived mechanical ankle instability along recurrent ankle sprain children history ankle sprain perceived instability reported whilst mechanical instability found children history recurrent ankle sprain found children conclusion due long lasting impacts cai future research measurement incidence ankle instability children recommended
laser sintered technology introduced clinical use utilized widely accompanied digitalization dentistry development direct oral scanning devices study performed aim comparing marginal accuracy internal fit alloy copings fabricated casting cad cam computer aided design computer assisted manufacture milled laser sintered techniques total alloy crown copings fabricated implant abutment marginal internal fit evaluated measuring weight silicone material vertical marginal discrepancy using microscope internal gap sectioned specimens data statistically analyzed one way anova analysis variance scheffe test pearson correlation significance level using statistics software silicone weight significantly low casting group laser sintered group showed highest vertical discrepancy marginal occlusal average internal gaps cad cam milled group revealed significantly high axial internal gap moderate correlations vertical marginal discrepancy internal gap variables except silicone weight study laser sintered group achieved clinically acceptable marginal accuracy internal fit
paper work related using webd based technology levels stimulating individuals lifelong learning presented work addressed gap showing longitudinal investigation results referent stimulating young children lifelong learning support emerging digital technologies since levels impact individuals lifelong development based qualitative data collected action research ethnographic techniques natural settings longitudinal investigation described case study presents former student lifelong learning professional development based used scientific knowledge integrated computer science features interactive computer graphics computer programming techniques tools create complex digital environments content dde qualitative result support innovation diffusion theory computational thinking human computer interaction instructional scaffolding former student trajectory showed potential stimulating ones lifelong learning cognitive abilities enhancements using webd technology addition work brought empirical possibilities stimulating cross disciplinary collaborative teachers training teaching service based diffusing advanced scientific dde knowledge innovation promoting sociotechnical development since levels
theoretical studies pollution hypothesis predict differentiated environmental regulation policies result inter country relocation polluting industries paper investigates pollution hypothesis domestic level china using panel data provincial level regions period paper empirically examines extent multiple environmental policies affect intra country relocation polluting industries china found implementation economic policy instrument like pollution discharge fee public participation like letter complaints environmental problems encourages industrial relocation whereas implementation environmental legal policy instrument like laws regulations rules prevents polluting industries relocating regions also found relocation effect environmental policies varies industrial characteristics compared water pollution intensive industry air pollution intensive industry dominated stated owned capitals insensitive legal policy instruments findings suggest validity pollution hypothesis jointly associated type environmental policy well industrial characteristics elsevier ltd rights reserved
water pollution complex problem removal various pollutants along microbes need multifunctional materials make polluted water potable selective removal highly toxic pollutant ions wastewaters area critical significance study report functional material derived vinylformamide nvf highly selective high adsorption capacity ions also acts biocidal agent representative microorganisms gram epidermidis gram typhi bacteria fungus albicans effect different parameters well competing ions ions adsorption capacity studied material reported article represents important advance earlier reported materials elsevier rights reserved
background respiratory syncytial virus hospitalization rsvh rates children dose palivizumab hospitals demographic data collected enrollment rih events recorded monthly infants months age hschd recruited results hschd infants first year mean age months second year life mean age months received prophylaxis baseline demographics day care attendance multiple births enrollment age weight differed groups additionally second year infants complicated neonatal course significantly longer length stay days compared first year rih rsvh rates first year second year cox regression analysis showed similar hazard rih hazard ratio confidence interval rsvh hazard ratio confidence interval conclusions infants first second year life similar rsvh hazard findings suggest infants second year hschd remain unstable equally risk rsvh merit prophylaxis
vehicle induced vibration important consider assessing structural safety bridges issue widely investigated recent years open literature current research studies mainly emphasize effects bridge span vehicle however driving effects driving speed vehicle model parameters driving conditions rarely investigated study researches driving effects vehicle induced vibration long span suspension bridges conducted first typical three dimensional vehicle model multi axils proposed three different road roughness models rated excellent good normal generated power spectral density random traffic flow vehicle types simulated using proposed random traffic flows model generation program next effective finite element model ishikawa beams stiffening girder established investigate driving effects vehicle induced vibration calculations effects vehicle body parameters road roughness driving direction speed performed possible reasons driving effects vehicle induced vibration long span suspension bridges also discussed addition conclusions recommendations future bridge analysis design provided based results study copyright john wiley sons ltd
advanced space borne thermal emission reflection radiometer aster one five sensors nasa terra satellite orbit since december aster consists three radiometers visible near infrared vnir short wave infrared swir thermal infrared tir whose spatial resolutions respectively unfortunately swir image data saturated since april due offset rise caused cooler temperature rise vnir tir taking earth images good quality vnir tir experienced responsivity degradation swir showed little change lamp calibration band decreased among three vnir bands thirteen years vnir electrical calibration mode check healthiness electrical circuits charge coupled device ccd four voltage levels line line input ccd onboard calibration sequence output digital numbers dns detected images input voltages monitored telemetry data stable electrical calibration check stabilities offset gain ratio gain stability electric circuit output level line input close offset level measured observing earth night trend line output compared offset level similar exactly trend even pixel odd pixel saturated offset levels odd pixel corrected using even pixel trend gain ratio trend shows ratio stable ratio values different measured launch difference comes band correct gain ratio applied vicarious calibration result onboard calibration measured normal gain whereas vicarious calibration often measures high gain cause vnir responsivity degradation known one causes might change electric circuit band gain shows decrease whereas gain changes band band responsivity decrease days since launch might controlled electric circuit change
dietary patterns influence various cardiometabolic risk factors including body weight lipoprotein concentrations function blood pressure glucose insulin homeostasis oxidative stress inflammation endothelial health mediterranean diet described dietary pattern characterized high consumption plant based foods olive oil main source fat low moderate consumption fish dairy products poultry low consumption red processed meat low moderate consumption wine meals american diabetes association american heart association recommend mediterranean diet improving glycemic control cardiovascular risk factors type diabetes prospective studies show higher adherence mediterranean diet associated reduced risk developing type diabetes results randomized controlled trials show mediterranean diet reduces glycosylated hemoglobin levels also associated reduced risk cardiovascular events mechanisms mediterranean diet produces cardiometabolic benefits type diabetes anti inflammatory antioxidative increased consumption high quality foods may cool activation innate immune system reducing production proinflammatory cytokines increasing anti inflammatory cytokines may favor generation anti inflammatory milieu turn may improve insulin sensitivity peripheral tissues endothelial function vascular level ultimately act barrier metabolic syndrome type diabetes development atherosclerosis
background children adults lysosomal storage diseases mucopolysaccharidosis mps types live shortened lives permeated chronic pain physical disability current treatments alleviate problems thus critical need understand mechanism chronic pain disability mps order improve way treat patients potential target inflammation hypothesis hypothesized excessive inflammation mediated tumor necrosis factor alpha tnf alpha inflammatory pathway fundamental cause much chronic pain physical disability mps methods patients mps enrolled course year prospective longitudinal natural history study evaluated annually years healthy controls enrolled separate cross sectional study bone energy metabolism tnf alpha measured elisa pain physical disability measured children health questionnaire parent form chq differences log transformed tnf alpha levels associations chq domains evaluated using linear mixed effects model random intercept results tnf alpha levels measured mps age years female controls age years female among mps treated hematopoietic cell transplantation alone enzyme replacement therapy ert alone hct ert tnf alpha levels higher mps compared healthy controls higher tnf alpha levels associated increased pain decreased physical function social limitations due physical health physical summary score tnf alpha levels significantly associated general health score tnf alpha levels change significantly time mps conclusions higher tnf alpha levels implicated pain decreased physical function present individuals mps despite treatment ert hct suggesting tnf inhibition could potentially useful adjunctive therapy investigation role tnf alpha inhibition mps decrease pain improve physical function indicated elsevier inc rights reserved
measurement large deformations represents challenging issue many engineering applications name morphing deployable aerospace structures due intrinsic large deformations require dedicated sensing systems able capture current geometry shape reconstruction detect stress level structural health monitoring conventional sensors one hand due material structural limitations could assure adequate measurement may interfere instrumentation optical fiber technologies present advantages terms channels number wiring needs furthermore specific information carrier light prevents interference onboard systems finally limitations measurement due glass intrinsic fragility may overcome integrating sensors dedicated strain modulation supporting structure paper hand focuses fiber brag grating fbg based sensors conceived modulate large strains transducer design phase illustrated moving specifications design parameters identified optimal configuration assessed preliminary demonstrators manufactured tested allowing comparison numerical outcomes proposed concepts exhibited wide measurement range high level versatility due possibility tuning sensors different measurement conditions work ends critical discussion enhancements achievable activities yet necessary increase readiness level
introduction recent years explosion development medical apps apps available nearly apps allow women track fertility menstrual cycles used avoid achieve pregnancy apps offer convenient way track fertility biomarkers however use evidence based fertility awareness based methods fabms ideal use rates effectiveness similar commonly used forms hormonal birth control since baby preventing pregnancy important responsibilities critical women couples access reliable evidence based apps allow accurately track fertility methods developed tool evaluate rate fertility apps tool specifically designed help couples avoid pregnancy results results showed majority fertility apps based evidence based fabms include disclaimer discouraging use avoiding pregnancy however least app fabm category except symptohormonal methods perfect score accuracy conclusion relying solely app use fabm without appropriate training method may sufficient prevent pregnancy
current studies presented multiple understandings meanings concept agile project management however formal definition agile project management relates underlying theoretical foundation project management agile project management literature study presents various concepts project project management order articulate final research based definition agile project management consequently formal definition agile project management constructed result paper concludes set recommendations research agile project management paper portion ongoing computer information system research effort agile frameworks
paper presents research durability static long lasting life fatigue life selected adhesive composites belzona epoxy adhesives physically modified metallic ceramic fillers tests conducted determining creep curves short term strength lap joints static long lasting life adhesive joints adhesive composites numerical calculations conducted finite element method made order explain basis distribution stress strain phenomena occurring long term load adhesive bonded joint unobservable experimental research regard comparative analysis needs research results gained belzona composites compared results gained adhesive based physically unmodified epidian epoxy composition hardened triethylenetetramine epidian teta
objective investigate clinical characteristics developmental profile child abuse victims assessed child assessment service cas hong kong method retrospective chart review conducted children multidisciplinary case conference concluded child abuse victims assessed cas studied age sex condition matched comparison group also selected comparison results fifty five children boys girls studied developmental delay intellectual disability attention deficit hyperactivity disorder problem two major developmental disabilities identified types abuse included physical abuse neglect sexual abuse multiple abuse abusers parent parents psychiatric problems substance abuse single parenting low income families children sibling developmental problems associated higher risk child abuse conclusions psychosocial risk factors child abuse identified children developmental problems assessed cas support children disadvantaged families important child protection
paper reviews importance device circuit interactions dci consideration designing thin film transistor circuits systems examine temperature process induced variations propose way evaluate maximum achievable intrinsic performance tft aimed determining dci becomes crucial specific application compensation methods reviewed show examples dci considered design amoled displays designs analog front end image sensors also discussed alternate circuits designed overcome limitations intrinsic device properties
human agent societies refer applications virtual agents humans coexist interact transparently fully integrated environment one important aspects kind applications including emotional states agents humans decision making process sense paper presents applicability jacalive jason cartago implemented intelligent virtual environment framework developing kind society specifically paper presents ambient intelligence application humans immersed system extracts analyzes emotional state human group social emotional model employed try maximize welfare humans playing appropriate music every moment
series novel benzo oxazole derivatives synthesized biologically evaluated potential inhibitors acetylcholinesterases ache butyrylcholinesterase bche chemical structures final compounds confirmed spectroscopic methods vitro studies showed synthesized compounds potent acetylcholinester ase butyrylcholinesterase inhibitors among compounds strongly inhibited ache bche activities values respectively docking studies also provided binding modes action identified hydrophobic forces main interaction
number previous studies focused effect sport practice eating disorders substance use studies suggest among students sport practice related low levels health issues like eating disorders substance use however relative dearth evidence relationships previous findings based comparisons people involved sport practice physical activity sedentary largely inactive people present study aims test effects frequency sport practice college students eating disorders substance use also controlling gender effects methods one thousand seventy three first year college students boys girls volunteered participate study participants divided three groups according frequency sport practice students rarely participated sport practice less one hour week every week students boys girls students frequently participated sport practice every week less eight hours week students boys girls students intensive sport practice eight hours week students boys girls alcohol tobacco cannabis use assessed using alcohol smoking substance involvement screening test assist three different categories eating disorders dieting bulimia oral control assessed using eat inventory anovas computed test gender differences across three sport practice groups results results univariate anovas revealed main effects gender sport practice substance use eating disorder variables anova multiple comparisons tamhan test revealed significant interaction effect sport practice gender oral control tobacco use girls oral control tobacco use vary within three groups sport practice whereas boys frequent sport practice lower scores oral control tobacco use oral control boys reported significantly higher scores girls sport practice rare tobacco use boys reported significantly higher scores girls sport practice rare lower scores sport practice intensive conclusion results suggest positive effects sport practice vary gender campaigns promotion physical activity might assist prevention health issues amongst students adapted according gender participants published elsevier masson sas behalf societe francaise psychologie
background evaluated facilitation strategy help clinical sites likely experience challenges implement evidence based primary care mental health integration mhi care models within context department veterans affairs initiative article describes assessment whether implementation facilitation foster development high quality mhi programs adhere evidence sustainable likely improve clinical practices outcomes methods utilizing matched pair design conducted qualitative descriptive evaluation strategy sixteen primary care clinics assess program quality adherence evidence conducted one hour structured telephone interviews two time points clinicians leaders knew clinics programs created structured summaries interviews national mhi experts utilized rate programs four dimensions overall quality adherence evidence sustainability level improvement results first assessment seven eight sites four eight comparison sites implemented mhi program qualitative assessment suggested experts rated sites programs higher comparison sites programs one exception final assessment eight five comparison sites implemented mhi program experts rated sites programs higher matched comparison sites one exception time ratings improved five seven sites two three comparison sites conclusions implementing complex evidence based programs particularly settings lack infrastructure resources support efforts challenging findings suggest blend external expert internal regional facilitation strategies implementation scientists developed tested improve mhi program uptake quality adherence evidence primary care clinics challenges however sites showed improvements successful facilitators likely need least moderate level leaders support including provision basic resources additionally found strength leadership structure may synergistic effect ability implement higher quality evidence based programs
backgroundfew occupational health safety studies focused seafood preparation packaging industry none oregon seafood industry methodsoregon workers compensation disabling claims data analyzed oregon employment department census bureau data used denominators rates resultsduring accepted disabling claims average annual rate claims per workers men experienced significantly higher rate per women frequent incident characteristics circumstances naturetraumatic injuries muscles tendons ligaments joints body partupper extremities eventoverexertion bodily reaction contact objects equipment conclusionanalyzing disabling claims data provides important preliminary information understanding workplace hazards develop control strategies reducing traumatic cumulative injury risk among seafood workers paramount
morbid obesity remains one society significant medical dilemmas rapidly worsening expected affect population year common current bariatric procedures exist include limited adjustable gastric band gastric bypass sleeve gastrectomy although beneficial morbidly obese patients also alter patient anatomy involve resections require maintenance goal trial show new minimally invasive vertical gastric clip technique produces significant weight loss requires resection change anatomy reversible november february prospective collected data patients included gastric clip trial clip consists silicone covered titanium backbone inferior hinged opening separates medial lumen excluded lateral gastric pouch inferior opening allows gastric juices empty fundus body stomach distal antrum weight loss comorbidities evaluated among patients month period excess weight loss seen minimal adverse events average length surgery min average length stay days fifteen originally implanted clips electively removed based original protocol two removed displacement device vertical gastric clip trial shown excellent weight loss achieved without complications seen historical bariatric procedures clip placed without requiring stapling resection malabsorption change anatomy maintenance also easily reversible
coordinated intrusion like ddos worm outbreak botnet major threat network security nowadays continue threat future ensure internet security effective detection mitigation attacks indispensable paper propose novel collaborative intrusion prevention architecture cipa aiming confronting coordinated intrusion behavior cipa deployed virtual network artificial neural net substrate networks taking advantage parallel simple mathematical manipulation neurons neural net cipa disperse lightweight computation power programmable switches substrate programmable switch virtualizes one several neurons whole neural net functions like integrated ids ips allows cipa detect distributed attacks global view meanwhile require high communication computation overhead scalable robust validate cipa realized prototype software defined networks also conducted simulations experiments results demonstrate cipa effective elsevier ltd rights reserved
letter presents single step tunable group delay phaser spectrum sniffing device may seen time filter frequencies suppressed time separation rather spectral attenuation compared multiple step counterpart phaser features higher processing resolution greater simplicity lower loss better channel equalization due smaller channel independent group delay swing two channel example provided illustration
group call major service tetra terrestrial trunked radio networks cases group call conflict occurs paper presents method resolve group call conflict merging users requesting initiate existing group call ongoing call addition paper also comes method shorten call set time setting time delay call clear channel release group call initiated frequently means user experience system performance improved state machine design process design described details experimental test result proven effectiveness method
paper presents educational experience initial course feedback control purpose introduce concepts robust design included regular curriculum problem designing controller simple mechanical system without knowing true value parameters proposed laboratory class task performed real system aid computer aided design freeware combination practice software tools encourages development autonomous learning favours apprehension concepts uncertainty robustness perception survey shows promising results indicating strategy learning well accepted students
year old female presented first case knowledge new daily persistent headache ndph large right benign non toxic multinodular goiter causing carotid vertebral compression complete resolution headache immediately thyroidectomy although may quite rare hypothyroidism hyperthyroidism causing ndph migraine exacerbation pre existing migraine clinicians consider routinely obtaining serum thyroid stimulating hormone tsh free patients new onset frequent headaches exacerbation prior primary headaches
inflammation may play role development epilepsy brain insults binds tspo expressed activated microglia quantified binding epileptogenesis pilocarpine induced status epilepticus model temporal lobe epilepsy nine male rats studied thrice induction session weighted images dti mean diffusivity fractional anisotropy maps acquired followed dynamic pet femoral arterial blood sampled rat specific metabolite corrected arterial plasma input functions aifs multiple derived rois assessed four kinetic models two aifs two using reference region standard uptake values suvs model mean aif models showed large two fold significant tspo binding increases regions expected affected comparatively little change brainstem individuals showed increases aif models yielded consistent increases values decreased recovered increased pet binding biomarker changes could detected nine rats highlighting potential longitudinal imaging studies
report sno quantum dots anchored tio nanospheres tio sno composites synthesized simple one step hydrothermal process employed photocatalyst photodegradation system microstructure tio sno composites reveals sno quantum dots dispersed surface tio nanospheres uniformly photocatalytic behavior prepared samples revealed composites exhibited highly efficient performance degrading methylene orange min completely ultraviolet visible light owning special structure composites tio sno shows vis light absorption either pure tio nanospheres pure sno quantum dots study offers facile method prepare tio sno composites choice greatly extending potential applications water pollution treatment degradation pollutants related fields elsevier ltd techna group rights reserved
contraception important issue matter concern every medical visit adolescent young patients chronic rheumatic diseases narrative review discusses contraception methods adolescents juvenile systemic lupus erythematosus jsle antiphospholipid syndrome aps juvenile idiopathic arthritis jia juvenile dermatomyositis jdm barrier methods safe use encouraged adolescents chronic rheumatic diseases combined oral contraceptives coc strictly prohibited jsle aps patients positive antiphospholipid antibodies reversible long acting contraception encouraged offered routinely jsle adolescent patient rheumatic diseases progestin pills safe majority rheumatic diseases although main concern related use adolescents poor adherence due menstrual irregularity depot medroxyprogesterone acetate injections every three months highly effective contraception strategy although long term use associated decreased bone mineral density coc combined hormonal contraceptive may options jia jdm patients oral levonorgestrel considered emergency contraception method adolescents chronic rheumatic diseases including patients contraindication coc published elsevier editora ltda
representing human knowledge plays important role artificial intelligence science nowadays many effective methods representing knowledge semantic networks conceptual graphs computational networks computational objects knowledge base cokb used represent knowledge many kinds knowledge domain linear algebra analytic geometry direct current electrical circuits however cokb model used represent knowledge solve problems chemical elements efficiently paper propose variation cokb model called che cokb useful tool represent knowledge chemical elements solve kinds problems knowledge domain furthermore algorithms solving problems model built addition proposed model algorithms also applied construct application solving problems chemical elements mobile devices
water pollution permit systems challenging design implement operational systems maintained functionality remains far particularly developing countries present current progress towards developing system nutrient enrichment based water pollution mainly commercial agriculture applied production function approach first estimate monetary value impact pollution used reference point establishing reserve price pollution permits subsequent market making process explained according five steps including permit design terms conditions transactional protocol monitoring system piloting implementation monetary value impact pollution estimated per hectare per year provide management budget filamentous green algae mitigation strategies study area also enabled calculation reserve price filamentous green algae pollution permits estimated per gram filamentous algae per gram preferred state elsevier ltd rights reserved
frequency transformation methods like fast fourier transform algorithms competently used realization discrete fourier transforms galois field broad applications network security digital communication error correcting codes cyclotomic fast fourier transform cfft type fast fourier transform algorithm finite fields method utilizes benefit cyclic decomposition cyclotomic breakdown input data used reduce number operations equally exploited get set set treatment input sequence common subexpression elimination cse useful optimization process solve multiple constant multiplication problems paper common subexpression elimination algorithm cyclotomic fast fourier transform fixed field designed using cse algorithm reduce additive complexities cyclotomic fast fourier transform design cse spot regular patterns present expressions replace single variable using method every regular pattern calculates thus minimizing area cfft architecture required vlsi implementation
infrastructure services essential human development yet drivers service access global scale remain largely unexplored paper presents trends global patterns access water sanitation electricity telephony services using panel data set empirically explore plausible determinants access rates key infrastructure services although per capita gdp correlated access rates access still varies significantly comparable income levels much variation explained differences population density access levels higher urban areas highest water followed sanitation electricity telephony elsevier ltd rights reserved
present article focused computational fluid mechanics study local viscous flow dynamics formation character rotary modes deformation equal channel multiple angular extrusion ecmae polymer workpiece fluid model shaped die parallel slants channel intersection zones present local flow problem experimentally analyzed using physical simulation methods theoretically studied numerical fluid mechanics techniques computational approach grounded numerical finite difference solution boundary value problem navier stokes equations curl transfer form local viscous flow incompressible newtonian fluid shaped rectangular die parallel slants derived research results allow draw conclusion implementation geometric design parallel slants within turn shaped die results localization maximum tangential stresses within workpiece volume vicinity parallel slants ecmae
three crystal phases bipo hbip nmbip mmbip corresponding photocatalysts yalo hbip yalo nmbip yalo mmbip nanocomposite photocatalyst yalo bip prepared hydrothermal ultrasonic dispersion liquid boiling methods prepared photocatalysts characterized ray diffractometer xrd energy dispersive ray spectroscopy edx scanning electron microscopy sem vis diffuse reflectance spectra drs catalytic activity prepared photocatalysts evaluated via photocatalytic conversion rate nitrite ultraviolet light visible light simulated solar light irradiations three photocatalysts exhibited excellent performance simulated solar light irradiation reached conversion rates respectively yalo mmbip yalo nmbip yalo hbip particularly yalo bip also found play high catalytic activity resulting conversion rates respectively ultraviolet light visible light simulated solar light irradiation addition study used times showed prepared photocatalysts effectively recycled without apparent inactivation photocatalytic activity research may provide potential way converting nitrite contaminants utilizing solar energy efficiently korean society industrial engineering chemistry published elsevier rights reserved
application stimuli responsive medical practices emerged sensitive liposomes figure prominently study investigates impact incorporation different amounts sensitive polymer paa poly acrylic acid hydrophobic end group alpha phosphatidylcholine hydrogenated soy hspc phospholipidic bilayers respect biomimicry functionality paa poly carboxylic acid molecule classified sensitive polymer whose sensitivity attributed regulative cooh groups protonated acidic pka similar concern fully characterize biophysical thermodynamical manner mixed nanoassemblies arising combination two biomaterials first quantified physicochemical characteristics physical stability prepared chimeric nanosystems studied thermotropic behavior measurement thermodynamical parameters using differential scanning calorimetry dsc finally loading release indomethacin ind evaluated well physicochemical properties stability nanocarriers incorporating expected thermodynamical findings line physicochemical results also explain loading release profiles ind novelty investigation utilization sensitive chimeric advanced drug delivery nano systems addnss targeted drug delivery relies entirely biophysics thermodynamics designs physiological membranes environment living organisms
introduction olfactory hallucination migraine attack ohm rare phenomenon present considered manifestation migraine aura material methods clinical features ohm collected patients results patients migraine without aura one migraine aura associated ohm mean age onset headache appearance ohm respectively years migraine average frequency attacks month associated ohm temporal pattern ohm maintained characteristics different attacks ohm onset described sudden gradual initially sudden gradual developing seconds cases ohm lasted minutes persisted pain phase hours three patients type perceived smell invariably constant nine patients conclusion ohm features fulfilled ichd iii beta criteria typical aura
simultaneous excitation multiple lateral modes due pedestrian loading observed london millennium footbridge clifton suspension bridge however previous experimental studies aiming determine pedestrian loading laterally oscillating ground focused single mode shortcoming arisen result lack capability previous experimental setups deliver multi mode vibrations consequence existing modelling approaches results tests single mode assumed representative pedestrian behaviour universally therefore uncertainty remains whether predictions dynamic structural behaviour models trusted address problem tests conducted newly developed instrumented treadmill mounted top hydraulically actuated base allowing treadmill motion representing simultaneous motion multiple bridge modes paper presents results tests relates performance inverted pendulum pedestrian model previously shown capable generating destabilising forces structure multiple modes simultaneously
low dose ray computed tomography ldct imaging highly recommended use clinic growing concerns excessive radiation exposure however images reconstructed conventional filtered back projection fbp method low dose acquisitions may severely degraded noise streak artifacts due excessive ray quantum noise view aliasing artifacts due insufficient angular sampling nonlocal means nlm algorithm introduced non iterative edge preserving filter denoise natural images corrupted additive gaussian noise showed superior performance since adapted applied many image types various inverse problems paper specifically reviews applications nlm algorithm ldct image processing reconstruction explicitly demonstrates improving effects reconstructed image quality low dose acquisitions effectiveness applications ldct relative performance described detail american association physicists medicine
background centers medicare medicaid services cms canceled meaningful use replacing advancing care information preserves many elements therefore transitioning stage stage important implications new policy yet quality care provided physicians transitioning unknown methods retrospective longitudinal evaluation quality care delivered outpatient physicians academic medical center transition results measures improved hypertension control influenza immunization tobacco use assessment counseling diabetes control one worsened senior weight screening follow two unchanged chlamydia screening adult weight screening follow conclusion single site study clinicians progressed quality measures improved unchanged worsened analysis national data guide policy decisions content successor
paper examines british women accounts buying wearing lingerie taken depth interviews exploring experiences shopping sex shops lingerie forms one part sexual consumer culture positioned within neoliberal discourse postfeminism women engagement representation lingerie way enact lingerie buying wearing everyday lives ways speak practices show complex often incongruous strategies accommodation negotiation strategies make lingerie pleasurable liveable whilst time expressing forms anxiety ambivalence laughter directed towards performance femininity feminine sexuality required represented lingerie contend precisely often contradictory engagement lingerie strategic counter discourses emerge women resist respectable norms female sexuality women position ambivalent ways relation visual imperative feminine sexuality represented lingerie particularly embodied discourse comfort discomfort playful pleasurable performance non naturalised gender roles
optimization cutting parameters important issues manufacturing engineering slender bar turning operations drum shaped error one important product quality characteristics work artificial neural network model developed firstly describe relationship cutting parameters drum shaped error slender bar turning process based obtained model cutting parameter optimized satisfy specified drum shaped error economics criterion multi pass turning slender bar due high complexity machining optimization problem genetic algorithm employed resolve problem experimental results show proposed optimization method effective efficient slender bar turning operations
research aimed studying possible advantages installing hybrid propulsion aircraft electric motors related propellers dedicated supplementary nacelles innovative solution different configuration already studied regional turboprop chiesa electric motors nacelles internal combustion engines expected offers advantages avoiding mechanical links two units importantly also applied jet aircraft fact main contribution electric motors expected ground operations take descent phases low speed useful integrate propellers even substitute jet engines high speed propellers course configured order reduce drag considering design new airliner concept preliminary design study necessary optimize location supplementary nacelles nacelles hold electrical motor also considered retractable usual rat ram air turbine please note hybrid propulsion context rat function clearly allocated electric motor advantages optimizing drag high speed taking account installation problems
paper introduces main topics related simulation based learning paper outlines advantages education technology explains operation case studies achieved authors
body shape related stimuli used bodyimage studies several limitations lack pilot validation procedures use non body shape related control neutral stimuli therefore developed database computer generated body pictures women wherein bodies methodically manipulated terms fatness versus thinness eighty two youngwomen assessed pictures attractiveness beauty harmony valence ratings body shape assessed thinness fatness axis providing normative data valence body shape ratings first stimuli manipulated fatness versus thinness conveyed comparable emotional intensities regarding valence body shape ratings second different subcategories stimuli obtained basis variations body shape valence judgments fat thin bodies distributed several subcategories depending valence ratings subcategory containing stimuli neutral terms valence body shape identified interestingly descriptive level thinness fatness manipulations bodies curvilinear relationship valence ratings thin bodies judged positive also negative estimated body mass indexes bmis decreased much finally convergent validity assessed exploring impacts body image related variables bmi thin ideal internalization body dissatisfaction participants judgments bodies valence judgments body shape judgments influenced participants levels thin ideal internalization body dissatisfaction participants bmis significantly influence judgments given findings database contains relevant material used various fields primarily studies body image disturbance eating disorders
bug reports one crucial information sources software engineering offering answers many questions yet getting answers always easy information bug reports often implicit processes required extract meaning reports research area employ supervised learning approach classify bug reports required types reports could identified however approach often requires immense amount time effort resources already scarce many projects aim develop automated framework categorize bug reports according grammatical structure without need labeled data framework categorizes bug reports according text similarity using topic modeling clustering algorithm group bug reports labeled new clustering labeling algorithm specifically made clusters topic space framework highly customizable modular approach options incorporate available background knowledge improve performance cluster labeling approach make use natural language process nlp chunking create representative labels experiment results demonstrate performance unsupervised framework comparable supervised learning one also show labeling process capable labeling cluster phrases representative cluster characteristics framework used automatically categorize incoming bug reports without prior knowledge automated labeling suggestion system tool obtaining knowledge structure bug report repository
due exciting catalytic activity selectivity tailoring nano catalysts consisting preferred crystal facets desired structural properties remains forefront materials engineering facile one step nonhydrolytic solvothermal synthesis nanocomposite reduced graphene oxide one dimensional nitrogen doped nbo nbox exposed facet described triethylamine performed dual role nitrogen source capping agent control size unidirectional growth nbo nanocrystallites nano composite showed efficient visible light mediated lambda water splitting photoelectrochemical cell plausible mechanism formation nbox nanorods improved photoelectrochemical efficacy terms oriented growth proposed
algebraic local cohomology classes associated parametric semi quasihomogeneous hypersurface isolated singularities considered context symbolic computation motivations paper computer calculations complete lists tjurina numbers semi quasihomogeneous polynomials isolated singularity new algorithm utilizes parametric local cohomology systems proposed compute tjurina stratifications associated constant deformations weighted homogeneous isolated singularities resulting algorithm gives particular suitable decomposition parameter space depending structure parametric local cohomology systems efficient algorithm computing parametric standard bases relevant ideals also given application parametric local cohomology systems
sliced ready eat traditional meat products presented individual packaging convenience consumer way food industry tries adapt new consumer tendencies current work assessed survival listeria monocytogenes contaminated sliced vacuum packed chourico different sugar concentrations two salt levels presence absence lactobacillus sakei starter culture along storage period two temperatures degrees degrees neither inoculation sakei addition carbohydrates influenced survival pathogen higher amount salt resulted signifi cant reduction monocytogenes storage higher temperature displayed safer product days monocytogenes detected samples study association factors contributing monocytogenes survival logistic regression showed increasing level salt addition reduces odds survival monocytogenes one fifth worthy attention signifi cant reduction odds nding viable monocytogenes samples stored room temperature degrees compared low temperature degrees general indiscriminate use refrigeration meat products might increase risk presence monocytogenes competitive advantage monocytogenes low temperatures potential inhibition lab activity probably reason observed behaviour amount salt important hurdle control monocytogenes growth manufacturing meat products lower salt contents meet demands healthy products might represent risk safety since high levels salt together low keys conservation
present application timepix detector vzlusat nanosatellite timepix compact pixel detector square pixels sensitive hard ray radiation suitable detecting extraterrestrial rays due low noise characteristics enables measuring without special cooling project aims verify practicality detector conjunction lobster eye optics observe celestial sources kev modified usb interface developed ieap ctu prague used low level control timepix additional bit atmel microcontroller dedicated commanding detector process data onboard satellite present software methods onboard post processing captured images suitable implementation constraints low powered embedded hardware several measuring modes prepared different scenarios including single picture exposure solar light triggered exposure long term sky monitoring work done within medipix collaboration satellite planned launch april part project end life expectancy
study compared diagnostic value whole body ultra low dose computed tomography wbuldct spinal magnetic resonance imaging smri identification spinal bone marrow involvement patients multiple myeloma thirty five patients histologically proven underwent wbuldct dedicated smri unenhanced wbuldct performed slice scanner mas smri performed magnet turbo spin echo short tau inversion recovery sequences sagittal plane wbuldct compared smri terms lesion detection pattern bone marrow involvement overall concordance wbuldct smri lesion detection detecting excluding involvement axial skeleton patients wbuldct smri discordant terms axial skeleton involvement concordance spinal distribution lesions cervical dorsal lumbar sacral pattern disease focal combined pattern cohen kappa index assessing excellent agreement wbuldct represents useful diagnostic tool detection spinal involvement patients offering detailed information extra axial involvement could potentially missed dedicated smri
explicit prediction suspended sediment loads rivers streams crucial sustainable water resources environmental systems suspended sediments governing factor design operation hydraulic structures like canals diversions dams recent decades model hydrological phenomena complex nature machine learning models used commonly present study support vector machine svm wavelet transform wasvm employed prediction daily suspended sediment load two south indian watersheds marol muneru using hydrometeorological data year daily observed data used analysis past streamflow rainfall data used model inputs model output using conventional correlation coefficient analysis input output variables best input wasvm model identified reliability svm wasvm models evaluated basis different performance criteria coefficient determination root mean square error rmse normalized mean square error nmse nash sutcliffe coefficient initially day ahead prediction performed using best wasvm model results showed day predictions precise showing close agreement observed data marol watershed muneru watershed testing period wasvm model used prediction higher lead periods nmse value marol watershed found low day ahead prediction increases subsequently day higher leads respectively likewise muneru watershed nmse value found low day ahead prediction increases subsequently day higher leads respectively model evaluated basis capability predicting peak cumulative day leads statistical analysis shows developed wasvm model predict target value successfully day lead suitable higher lead specifically selected watersheds similar hydroclimatic conditions like ones selected study predictions wasvm model found significantly superior ones obtained conventional svm model results revealed wasvm model provides good accuracy predicting used effective forecasting tool hydrological applications
main concern paper investigate stability properties namely aubin property isolated calmness special non monotone variational inclusion provide characterization properties terms problem data show importance design electrical circuits involving nonsmooth non monotone electronic devices like diac diode alternating current circuits devices like scr silicon controlled rectifiers zener diodes thyristors varactors transistors analyzed way
estrogen females conventionally considered cardioprotective influence role estrogen male cardioprotection yet defined estrogen biosynthesis testosterone regulated aromatase aromatase recently shown expressed adult heart although little known involvement regulation myocardial function stress responses goal study determine whether upregulation tissue aromatase expression could improve ischemic resilience male hearts isolated hearts male transgenic aromatase overexpressing arom high estrogen low testosterone mice wild type mice langendorff perfused subjected ischemia reperfusion min ischemia min reperfusion basal systolic function lower arom hearts max mmhg associated augmented akt phosphorylation consistent suppressor action estrogen contractility ischemic contracture attenuated arom hearts mmhg yet arom hearts arrhythmic early reperfusion end min reperfusion arom systolic functional recovery lower left ventricular developed pressure basal diastolic dysfunction accentuated mmhg first study show vivo aromatase upregulation modulates basal cardiac performance response ischemic stress data suggest chronic exposure enhanced estrogenic influence may benefits limiting ischemic contracture severity acute functional recovery reperfusion compromised temporally targeted tissue specific intervention combining aromatase treatment inotropic support may offer therapeutic potential men women
ambient intelligence aml discipline makes environments visit everyday sensitive adding sensors measure surroundings actuators interact environment people problem emerges trying convert space ambient intelligence environment modify one already exists simulator could help arrive optimal set without need expending money installing required devices sure achieved desired configuration paper propose architecture integration social simulation network simulation order create whole ambient intelligence environment simulator
recently demonstrated synchronous reluctance motor well suited electric well hybrid electric vehicles paper deeply investigates capabilities synchronous reluctance motor compares permanent magnet assisted synchronous reluctance motor according typical requirement traction application proper rotor design necessary average torque due rotor anisotropy permeance difference directand quadrature axis achieved means high number flux barriers position flux barrier ends proper rotor asymmetries chosen reduce torque ripple mainly due slot harmonics impact rotor design motor performance presented deeply showing several simulation experimental results carried synchronous reluctance motors different rotor geometries permanent magnets inset flux barriers assist synchronous reluctance motor improving capabilities avoiding use rare earth permanent magnets main advantages permanent magnet assistance increase main torque density power factor evaluated experimentally however drawback adopting permanent magnets possible demagnetization magnets greatly limit maximum overload capability motor salient requirement traction motor
challenge detecting explosive hazards multiple types targets buried different depths highly cluttered environment wide array target clutter signatures exist makes detection algorithm design difficult explosive hazards typically deployed past present war zones pose grave threat safety civilians soldiers alike paper focuses new image enhancement technique hand held ground penetrating radar gpr advantages proposed technique runs real time require radar remain constant distance ground herein evaluate performance proposed technique using data collected army test site includes targets varying amounts metal content placement depths clutter times day receiver operating characteristic roc curve based results presented detection shallow medium deeply buried targets preliminary results encouraging demonstrate usefulness proposed filtering technique
paper reviews key advances understanding hydrodynamics forming section papermaking years period papermaking advanced rather slow speed fourdrinier machines modern high speed twin wire formers advances described context technical problems faced time increase machine speeds improve paper properties scientific work advances machine design contributed greatly marvel modern papermaking includes machines wide operating speeds
new type woven geotextile referred wicking geotextile developed introduced market since wicking geotextile consists wicking fibers wick water unsaturated soils pavement structure thus resulting increase soil resilient modulus enhance performance roadways study physical model test developed evaluate effectiveness wicking geotextile soil moisture reduction roadway applications test box dimension length width heighr used study two hdpe plastic panels used separate box two sections one containing dehumidifier backfilled soil dehumidifier adopted collect water wicked soil wicking geotextile evaporated air test results show wicking geotextile wicked water soil even moisture content close optimum moisture content comparison soil moisture contents rainfall demonstrated wicking geotextile maintained soil moisture contents rainfall close rainfall effective distance soil moisture reduction elsevier ltd rights reserved
system widely considered one promising candidates board hydrogen storage due high reversible hydrogen capacity good reversibility favorable thermodynamics study show hydrogen storage properties linh mgh sample promoted addition onset temperature dehydrogenation linh mgh sample degrees showing reduction around degrees respect linh mgh sample hydrogenation tests indicate dehydrogenated linh mgh sample could fully absorb hydrogen degrees bar hydrogen pressure hydrogen recharged dehydrogenated linh mgh sample degrees bar hydrogen pressure even within investigation structural changes cycling absorption desortion hydrogen also performed moreover thermal conductivity milled linh mgh sample almost doubled addition without loss hydrogen capacity elsevier rights reserved
documentation psychopathology core clinical practice psychiatrist clinical psychologist however initial well training specialization fields particular aspect work receives scanty attention yet past years association methodology documentation psychiatry amdp system existence available tool serve precisely purpose offering systematic introduction terminology documentation psychopathology motivation development based need assessment procedure reliable documentation effectiveness newly developed psychopharmacological substances subsequently amdp system began applied context investigations number methodological issues psychiatry frequency specificity particular symptoms comparison rating scales system became increasingly important also clinical practice today represents used instrument documentation psychopathology german speaking countries europe paper intends offer overview amdp system origins design functionality initial account history development amdp system discussion turn focus system underlying methodological principles transfer clinical skills competencies practical application use research clinical practice finally potential future areas development relation amdp system explored
silicon photonics offers possibility reduction size weight power many optical systems could open ability build optical systems complexities would otherwise impossible achieve silicon photonics emerging technology already inserted commercial communication products technology also applied analog signal processing applications mit lincoln laboratory collaboration groups mit developed toolkit silicon photonic devices focus needs analog systems toolkit includes low loss waveguides high speed modulator ring resonator based filter bank silicon photodiodes components integrated together hybrid photonic electronic analog digital converter development performance devices discussed additionally linear performance devices important analog systems also investigated
paper presents novel effective edge preserving image smoothing method edge aware image manipulation method formulates smoothing problem minimizing convex object function constraint efficient solution optimization problem presented specifically method provides unified framework regularize edge texture pixels optimization geometric edges representing image structures well retained fine edges texture regions removed suppressed qualitative quantitative experimental results natural images computer generated structured images shown efficacy proposed method addition proposed method improve performance many image processing manipulation tasks including edge extraction simplification non photorealistic rendering detail contrast exaggeration hdr tone mapping block based discrete cosine transform bdct artifact removal content aware image resizing demonstrated experiments elsevier inc rights reserved
one main features nodes mobile hoc networks manets cooperation neighbors propagate data misusing feature malicious nodes cooperate normal nodes disrupt network operation reduce efficiency nodes attack network nodes prevent detected nodes using mobility characteristic nodes manets one effective ways detect malicious nodes using game theory focusing issue paper approach presented malicious node detection using games theory data exchange two nodes forms game history successful unsuccessful sending receiving data stored used future decisions malicious nodes detected game components sent received data well information stored different stages experimental results indicate density malicious nodes approximately reaches game repeated four times neighboring nodes proposed approach raises malicious node detection rate however density malicious nodes algorithm detect repeated six times
background study aimed assess relationship leisure time spent watching television computer aggressive violent behaviour children adolescents methods nationwide study school students aged years selected cluster stratified multi stage sampling method provinces iran world health organization global school based health survey questionnaire gshs used results overall children adolescents boys urban residents completed study participation rate risk physical fighting quarrels increased watching day leisure time computer work day total screen time day watching leisure time spent computer total screen time day increased risk bullying spending day watching total screen time increased risk bullied respectively relationship statistically significant leisure time spent computer conclusions prolonged leisure time spent screen activities associated violent aggressive behaviour children adolescents addition duration screen time association likely explained also media content
carbide drill important hole machining tool modern processing solutions set higher requirements accuracy efficiency carbide drill manufacturing paper presents detailed study mathematical models spiral groove conical flank cutter clearance proposes three practical reliable grinding methods using one standard straight wheel spiral groove ground controlling three crucial structure parameters spiral angle core diameter rake angle conical flank ground controlling relief angle chisel edge angle apex angle cutter clearance ground controlling ridge width clearance depth schemes wheel position parameters computed conveniently quickly using computer programming overcoming low calculation accuracy empirical formulae thereby enhancing efficiency using wheel position parameters codes applicable five axis cnc grinders obtained furthermore reliability proposed grinding methods verified cad simulation practical manufacture five axis cnc grinder
paper presents application hidden markov models hmm fixations sequences analysis examination concerns eye tracking data gathered performing simple comparison decision tasks four versions plain control panels panels displayed target current velocity either digital analog clock face speedometers subjects decide whether increase decrease current speed pressing appropriate button obtained results suggest females generally exhibit different covert attention patterns men moreover article demonstrates estimated four hmm three hidden states every examined control panels variant provides discussion outcomes
pediatricians job performance work engagement job satisfaction essential individual physician quality care little patients parents therefore important maintain possibly augment pediatricians individual professional competencies study developed implemented psychosocial competency training pct teaching different psychosocial competencies stress coping techniques investigated influence pct work related characteristics stress perception work engagement job satisfaction explored pediatricians outcomes satisfaction pct fifty four junior physicians working pediatric hospital departments participated training randomized intervention control group beginning follow groups answered self rated questionnaire perceived training outcomes work related factors intervention group showed job satisfaction significantly increased perceived stress scores decreased taking part pct substantial changes observed regard pediatricians work engagement participating physicians evaluated pct high scores training design content received outcome overall satisfaction training conclusion professional psychosocial competency training could improve junior pediatricians professional skills reduce stress perception increase job satisfaction psychosocial skills addition study indicates pct beneficial implemented group training program junior pediatricians work
alteration expression mirnas correlated different cancer types tumour stage response treatments context structurally responsive oligonucleotide based electrochemical impedimetric biosensor developed simple sensitive detection mirna highly specific biotinylated dna lna molecular beacon probe conjugated gold nanoparticles aunps create integrated dual function bio label biotin aunps biorecognition signal generation presence target mirna hybridisation takes place resulting activation biotin event makes biotin group previously protected steric hindrance stem loop structure accessible activated biotin aunps mirna complexes become available capture via supramolecular interaction onto nentravidin modified electrode electrochemical transduction binding event results decrease charge transfer resistance working electrode electrolyte interface biosensor responded linearly range mirna limit detection good reproducibility relative standard deviation rsd high selectivity mirnas mirna mirna sequences detection mirna spiked serum samples clinically relevant levels low range also demonstrated thus illustrating potential biosensor point care clinical applications proposed biosensor design based combination neutravidin transducing surface dual function biotin aunps bio label provides simple robust approach detection short length nucleic acid targets mirnas
opportunity use geostationary satellite radio signals high elevation angles determining parameters hydrometeors rain snow hail clouds discussed attenuation scattering radio waves allow one determine average moisture drop concentration stratocumulus clouds reflection radio waves cumulonimbus clouds provides information intensity hazard cloudbursts etc functional diagram equipment results experimental investigations main forms low middle high level clouds presented method cloud recognizing using geostationary satellite radiation promising equipment environmentally safe simple cheap
therapists potential clients similarly evaluate offices practicing clinicians furnishings therapist office create welcoming environment yet little research examines perceptions furnishings leading focus research previous study color photographs psychotherapists offices students favored clinical settings soft personalized orderly nasar devlin using photographs present studies licensed psychotherapists evaluate quality care comfort setting therapist qualities expected clients experience office judgments therapists thought clients would make high correlations earlier judgments students group composite evaluation improved significantly office became softer orderly brief report concludes recommending features likely create welcoming therapeutic office
introduction posttraumatic stress symptoms pts associated increased risk obstetric complications among pregnant survivors trauma abuse interpersonal violence little known pts affects women actual experiences obstetric care study investigated rate abuse history detected obstetricians whether abuse survivors experienced invasive exams typically indicated routine obstetric care whether psychological distress associated abuse survivors sense self efficacy communicating obstetric care needs methods forty one pregnant abuse survivors completed questionnaires abuse history current psychological distress self efficacy communicating obstetric care needs preferences electronic medical records emrs reviewed examine frequency invasive prenatal obstetric procedures removal clothing external genital examination pelvic exams procedures examine detection rate abuse histories initial obstetric visit results majority participants reported least one past incident violent physical sexual assault obstetricians detected abuse histories less one quarter cases nearly half participants received invasive exams non routine reasons pts depression symptoms associated lower self efficacy communicating obstetric care preferences discussion women risk experiencing distress obstetric visits undergoing potentially distressing procedures may also least likely communicate distress obstetricians results discussed implications improving screening abuse screening distress symptoms well need trauma sensitive obstetric practices
traditionally digital forensics focused artifacts located storage devices computer systems mobile phones digital cameras electronic devices past decade however researchers created number powerful memory forensics tools expand scope digital forensics include examination volatile memory well memory forensic techniques evolved simple string searches deep structured analysis application kernel data structures number platforms operating systems much research remains done paper surveys state art memory forensics provide critical analysis current generation techniques describe important changes operating systems design impact memory forensics sketches important areas research elsevier ltd rights reserved
false memories commonly activate anterior dorsolateral prefrontal cortex dlpfc hippocampus regions assumed work concert false memories would predict positive correlation magnitudes activity regions across participants however dlpfc may also inhibit hippocampus would predict negative correlation magnitudes activity regions present functional magnetic resonance imaging fmri study encoding participants viewed abstract shapes left right visual field retrieval participants classified old shape previously left right visual field followed unsure sure sure confidence rating contrast left hits left misses produced two activations hippocampus three activations left dlpfc participant activity associated false memories right left sure responses two hippocampal regions plotted function activity dlpfc region across participants one region left anterior prefrontal cortex negative correlation magnitudes activity region hippocampus suggests anterior prefrontal cortex might inhibit hippocampus false memories participants engage either anterior prefrontal cortex hippocampus false memories
forest structure stand level plays key role sustainable forest management since biodiversity productivity growth stability forest positively influenced managing structural diversity contrast field based measurements remote sensing techniques offer cost efficient opportunity collect area wide information forest stand structure high spatial temporal resolution especially interferometric synthetic aperture radar insar facilitates worldwide acquisition information independent weather conditions illumination convenient capture forest stand structure study purposes unsupervised two stage clustering approach forest structure classification based height information derived interferometric band sar data performed complex temperate forest stands traunstein forest south germany particular four dimensional input data set composed first order height statistics non linearly projected two dimensional self organizing map spatially ordered according similarity based euclidean distance first stage classified using means algorithm second stage study demonstrated band insar data exhibits considerable capabilities forest structure classification moreover unsupervised classification approach achieved meaningful reasonable results means comparison aerial imagery lidar data elsevier rights reserved
individuals diagnosed borderline personality disorder bpd exposed severe traumatic stressors thus frequently present symptoms posttraumatic stress disorder ptsd severe sleep disturbances often accompany complex cases changes sleep parameters therapy impact sleep treatment response barely studied narrative exposure therapy net evidence based approach treatment trauma related psychological disorders investigate effect net sleep patients bpd comorbid ptsd screened inpatients outpatients met inclusion criteria diagnoses according dsm minimum weeks stable medication patients allocated net treatment usual tau blocks polysomnographies psychological questionares performed directly months last therapy session aim pilot study investigate effectiveness trauma therapy net sleep quantity total sleep time sleep continuity sleep efficiency awakenings patients comorbid bpd ptsd participants net group compared received tau showed increased reduction sleep latency baseline end therapy reduction arousals time patients longer pre treatment total sleep time pre treatment rem sleep duration showed better outcome net respect ptsd symptoms net seems lead change sleep worse therapy seems improve sleep good treatment usual furthermore results provide evidence influence sleep structure baseline treatment success later
cadmium zinc telluride czt based detector system developed goal combining molecular breast imaging mbi magnetic resonance imaging mri address shortcomings modality czt detector system comprised four czt modules tiled array module consists pixels pixels features built asic fpga custom digital readout circuit board designed interface four modules microcontroller data acquisition system placed within bore discovery imaging performance modality evaluated using sequential simultaneous imaging protocols mean energy resolution gamma camera inside outside mri kev maximum increase integral uniformity using gradient echo mri sequence mean differential uniformity inside mri increased spatial resolution varied predictable manner fwhm collimator face collimator performance discovery using channel breast coil array measured without gamma camera present using gradient echo spoiled gradient echo imaging sequence realistic mtc filled breast like phantom containing two lesions lesion background ratio used assess feasibility serial simultaneous hybrid imaging sequential imaging resulted reduction mri snr decrease observed performing simultaneous scintigraphy imaging likely result interference originating czt detector modules associated analog electronics registered scintigraphic mri images display negligible geometric distortion imaged simultaneous serial imaging modes thus indicating feasibility combining mbi breast mri
general tensile forces hanger cables suspension bridge play important role evaluating bridge condition two tensile force estimation methods based string cable equation widely applied estimate tensile forces using measured frequencies hanger cables however methods applicable short hanger cables frequencies short cables severely sensitive flexural rigidity thus study tensile forces hanger cables shorter meters estimated back analysis cable frequencies measured gwangan suspension bridge korea verify feasibility back analysis results back analysis existing methods compared average measured tensile forces completion comparison inferred back analysis results reasonably agree average measured tension short hanger cable completion therefore concluded back analysis applied study appropriate tool estimating tensile forces short hanger cables
objective irritable bowel syndrome ibs common condition general practise affecting population western world clinical picture diarrhoea predominant ibs ibs resembles chronic diarrhoeic conditions microscopic colitis impossible separate clinical examinations lab tests done general practise aim study detect missed diagnoses using symptom based approach diagnosis ibs material methodology examined participants diagnosed ibs rome iii criteria participants underwent full clinical examination lab tests colonoscopy including mucosa biopsies histological examination results histological analysis revealed four cases participants years diagnosed ibs found biochemical clinical markers made possible differentiate ibs found participants diagnosed ibs conclusion long lasting unresolved diarrhoeic conditions present patients years age colonoscopy biopsy performed rule pathologies diagnosing ibs younger patients pronounced watery diarrhoea one consider colonoscopy individually response ibs treatment
present wizz open source user friendly software estimating redshift distributions photometric galaxies unknown redshifts spatially cross correlating reference sample known redshifts main benefit wizz separating angular pair finding correlation estimation computation output clustering redshifts allowing anyone create clustering redshift sample without intervention expert allows end user given survey select subsample photometric galaxies unknown redshifts match sample catalogue indices value added data file produce clustering redshift estimation sample fraction time would take run angular correlations needed produce clustering redshift show results software using photometric data kilo degree survey kids spectroscopic redshifts galaxy mass assembly survey sloan digital sky survey results present kids consistent redshift distributions used recent cosmic shear analysis survey also present results using hybrid machine learning clustering redshift analysis enables estimation clustering redshifts individual galaxies wizz downloaded http github com morriscb wizz
infants become increasingly helpful second year investigated experimentally whether adults explicit scaffolding influences development infants months old participated series simple helping tasks half infants received explicit scaffolding encouragement praise whereas half among younger infants months infants received explicit scaffolding helped twice often infants control group also helped several subsequent trials scaffolding provided predicted older infants affected explicit scaffolding results demonstrate influence social experiences early helping also effects scaffolding may depend developmental level child less explicit forms scaffolding may effective children older
latest time series research conducted madrid reported associations road traffic noise cause specific daily mortality based results research study presents health impact urban noise period number avoidable deaths various cardiovascular respiratory metabolic diseases impact noise cardiovascular mortality exceeds fine particles two population groups considered years age elsevier rights reserved
advances stem cell research development intelligent biomaterials three dimensional biofabrication strategies highly mimicked tissue organs engineered among biofabrication approaches bioprinting based inkjet printing technology promises deliver create biomimicked tissue high throughput digital control capacity single cell manipulation therefore enabling technology great potential regenerative medicine translational applications current advances organ tissue bioprinting based thermal inkjet printing technology described review including vasculature muscle cartilage bone addition benign side effect bioprinting printed mammalian cells utilized gene drug delivery achieved conveniently precise cell placement tissue construction layer layer assembly three dimensional tissues complex structures printed using converted medical images therefore bioprinting based thermal inkjet far optimal solution engineer vascular system thick complex tissues collectively bioprinting great potential broad applications tissue engineering regenerative medicine future advances bioprinting include integration different printing mechanisms engineer biphasic triphasic tissues optimized scaffolds understanding stem cell biology
mri scans brain obtained evaluation primary headaches adults incidental findings commonly present review prevalence incidental findings normal anatomical variants types presented
changing land use due rapid urbanization profound impact runoff urban watersheds spatial analysis urban watersheds felt necessary management surface subsurface water regimes significant increase impervious zones observed nagpur urban watersheds impacts runoff even flash floods observed study presents spatial temporal impacts change urban built area curve number runoff years study also analyzes effect slope values shows increases slope high resolution satellite images used map impervious surface areas isas show increase spearman pearson coefficients generated establish relationship runoff impervious surface areas vegetation index slope runoff coefficient hypothetically assumed rooftop rainwater harvesting considered estimated runoff reduces compared year study suggests increase impervious areas within urban watersheds utilized groundwater augmentation adopting rooftop rainwater harvesting techniques prevent flash floods
single nucleotide polymorphisms snps widely existed human genome associated many diseases traditional pcr based methods snp genotyping require protein enzyme precise control temperature removal resultant products making whole process labor intensive time consuming although quadruplex dnazyme based assays provide many advantages traditional approaches relatively low catalytic activity dnazyme becomes unfavorable factor application process therefore amplification dnazyme determination great desire bioanalysis work developed enzyme free non label dnazyme sensor snp genotyping based target catalyzed hairpin assembly cha dnazyme amplification proposed sensor carried microfluidic chemiluminescence assay sensitively discriminate hotspot snp single nucleotide variation human chromosome associated alzheimer disease absolute detection limit fmol
perceivers extractmultiple social dimensions another face race emotion dimensions become linked due stereotypes black individuals angry current research examined neural basis detecting resolving conflicts top stereotypes bottom visual information person perception participants viewed faces congruent incongruent stereotypes via variations race emotion neural activity measured using fmri hand movements route race emotion responses recorded using mouse tracking behaviorally index individual differences stereotypical associations categorization medial prefrontal cortex mpfc anterior cingulate cortex acc showed stronger activation faces violated stereotypical expectancies intersection multiple social categories race emotion regions highly sensitive degree incongruency exhibiting linearly increasing responses race emotion became stereotypically incongruent acc exhibited greater functional connectivity lateral fusiform cortex region implicated face processing viewing stereotypically incongruent relative congruent targets finally participants stronger behavioral tendencies link race emotion stereotypically categorization showed greater dorsolateral prefrontal cortex activation stereotypically incongruent targets together findings provide insight conflicting stereotypes nexus multiple social dimensions resolved neural level accurately perceive people elsevier inc rights reserved
broadcasting radio programs satellites mobile users operating many years united states canada south korea service generally called satellite radio provided band radio frequencies satellite radio users require near perfect service availability since users mobile automobiles handheld reception antennas receivers little gain necessitating high effective isotropic radiated power eirp satellite provide required availability particularly fading conditions despite using satellite directive transmitting antenna achievement high eirp requires satellite transmitter radio frequency power output typically achieved paralleling traveling wave tube amplifiers twtas configuration usage technical aspects satellite transmitters described satellite transmitters critical satellite radio service performance operating lifetime typically years importance detailed lifetime laboratory testing done twtas reported herein elsevier ltd rights reserved
ulipristal acetate upa mifepristone currently well established agents emergency contraception drugs selective progestogen receptor modulators shown better efficacy widely used levonorgestrel prevention pregnancy however limited information action upa sperm function present study compared vitro biological effects mifepristone upa human sperm functions spermatozoa semen samples normal semen parameters isolated capacitated spermatozoa pre incubated mifepristone upa sperm motility viability dna integrity capacitation spontaneous acrosome reaction spontaneous hyperactivation zona pellucida binding capability intracellular calcium concentration determined effects mifepristone upa progesterone induced acrosome reaction hyperactivation also studied results showed mifepristone upa dose dependently suppressed progesterone induced acrosome reaction hyperactivation concentrations human spermatozoa compounds affect sperm motility viability dna integrity capacitation spontaneous acrosome reaction spontaneous hyperactivation binding capability study demonstrated upa mifepristone modulate human sperm functions acting progesterone antagonists results enable gain better understanding mechanisms mifepristone upa work emergency contraception provide scientific basis clinical application
aromatase inhibitors als area class drugs act blocking production estrogens androgens current review concentrates prenatal developmental toxicity als experimental models available data indicate als may affect pregnancy human therapeutic lower doses window vulnerability ais limited organogenesis also includes preimplantation stage fetal periods decreased embryo fetal survival prominent treatment related effect morphological anomalies noted fetuses exposed als included skeletal anomalies abnormal head morphology increased ano genital distance female fetuses minor urinary tract system anomalies placental enlargement consistently reported rats non human primates maternal treatment several ais conclusion data basic scientific research suggest low intensity exposure als applied wide gestational window profoundly affect prenatal development elsevier inc rights reserved
ability save state running virtual machine later restoration important tool home server virtual desktop cloud vdc environments order achieve optimal balanced hardware utilization guest memory sizes four eight gigabytes norm time space overhead storing checkpoints still prevents effective use technique work presents method fast space efficient checkpointing vms based observation operating systems cache disk blocks memory proposed technique transparently intercepts operations maintains date mapping memory pages disk blocks containing identical data checkpoint memory pages excluded checkpoint image leading significant reduction time space required take checkpoint running broad applicability good performance proposed method demonstrated extensive set experiments implemented technique para virtualized pvhvm fully virtualized hvm guests xen hypervisor comparison unmodified xen hypervisor experiments linux windows guests average achieve percent reduction stored data percent shorter time required take checkpoint pvhvm hvm linux hvm windows guests respectively
objective insufficient sleep risk factor pediatric obesity latino children among groups short sleep duration obesity prevalent therefore study sought explore latino parents views ideal sleep duration sleep related practices preschoolage children urban setting methods october january latino parents year old children interviewed pediatric clinics san francisco calif using semistructured interview guide parents asked describe bedtime routines sleep practices preschool age children including behavioral parental social contextual factors may affect children sleep interviews conducted spanish english parents also completed brief survey demographic information interviews analyzed basis priori emergent themes results latino parents mostly female mean age years foreign born half monthly household income less following themes emerged parents ideas optimal sleep duration preschool age child consistent bedtime routines room sharing bed sharing parent work child school schedules affect children sleep crowded housing neighborhood noise disrupt children sleep conclusions findings increase understanding factors related achieving optimal sleep duration among latino children living urban often crowded housing findings could used inform future research increase parental knowledge healthy sleep practices adequate sleep among latino parents young children
previous studies borderline personality disorder bpd development suggest transgenerational transmission parent child relationship quality may also influenced parents mental health status aim study twofold first aimed investigate transgenerational effect parental bonding experiences development bpd offspring second examined association parents mental health status bpd offspring ninety one female adolescent psychiatric inpatients along mothers fathers enrolled study adolescent bpd assessed structured clinical interview dsm parental bonding parental bonding instrument parents psychiatric symptoms patient health questionnaire found low parental care produced transgenerational effect mother bpd offspring significant associations found paternal psychiatric symptoms adolescent bpd high paternal stress levels mediated association maternal affect reported fathers bpd daughters evidence transgenerational effect parental bonding specifically female adolescents bpd compared clinical control subjects findings highlight importance including parents future research early clinical treatment adolescents bpd
general idea probiotics given links dietary fibre human beings must associated microorganisms skin hundreds grams bacteria although surprisingly gastric tract calculated microorganisms called intestinal flora words faeces dominant genera faeces belonging class anaerobic bacteria including bifidobacteria group includes facultative bacteria numbers relatively low faeces fewest bacteria pathogenic clostridium perfringens coli belong class iii mitsuoka small intestine possesses relatively low numbers bacteria however organ important particular immune trap bacteria peyer patch scattering area large intestine largest house microbes aging known invite significant reduction bifidobacteria beneficial bacteria diet influences intestinal flora balance well probiotic bacteria belong group usually transient bacteria proven give beneficial effects digestive immune systems example bifidobacterium breve strain yakult improved growth preterm infants kitajima lactobacillus casei shirota reported improve constipation koebnick increase natural killer cell activity streamline habitual intake probiotic strain reported reduce risk bladder cancer aso ohashi addition many reports probiotic strains improving digestive health duggan
objective evaluate effect comorbid disease weight loss years roux gastric bypass rygb surgery morbid obesity large nationwide cohort background number patients surgical procedures treat obesity obesity related disease increasing yet population based long term outcome studies methods data individuals women years body mass index bmi undergoing primary rygb may june collected swedish quality registries scandinavian obesity surgery registry prescribed drug registry weight remission type diabetes mellitus hypertension dyslipidemia depression sleep apnea changes corresponding laboratory data studied five year follow eligible individuals comorbid diseases results bmi decreased years corresponding reduction total body weight prevalence type diabetes mellitus hypertension dyslipidemia sleep apnea reduced greater weight loss positive prognostic factor whereas increasing age bmi baseline negative prognostic factor remission use antidepressants increased laboratory status improved example fasting glucose glycated hemoglobin decreased mmol mol respectively conclusions nationwide study gastric bypass resulted large improvements obesity related comorbid disease sustained weight loss year period increased use antidepressants warrants investigation
background awareness chronic kidney disease ckd suboptimal among patients ckd perhaps due poor readability patient education materials pems reviewed suitability readability common pems focused content areas basics ckd risk factors ckd development risk factors ckd progression complications ckd self management strategies improve kidney health methods three reviewers nephrologist primary care physician patient used suitability assessment materials rate pems message content stimulation learning typography visuals layout determined literacy level mean ratings calculated pem content area overall superior adequate inadequate linear regression used determine impact literacy level mean rating results reviewed pems organizations divided content area sections pem sections adequate mean rating inclusion patient centered content opportunities patient interaction associated superior ratings mean ratings similar across content areas basics ckd risk factors ckd development risk factors ckd progression ckd complications self management strategies grade associated point higher mean rating conclusion pems kidney disease adequate outstanding pems shared characteristics patient centeredness low literacy level patient interaction providers aware strengths limitations pems educating patients ckd karger basel
dissemination implementation evidence based behavioral medicine interventions real world practice limited purpose paper discuss specific limitations current behavioral medicine research within context aim framework potential opportunities increase public health impact applying novel intervention designs data collection approaches framework recently emerged alternative approach development evaluation aims optimize multicomponent behavioral bio behavioral interventions smart designs imbedded within framework approach optimize adaptive interventions addition innovative design strategies novel data collection approaches potential improve public health dissemination include mhealth approaches considering environment potential data source finally becoming involved advocacy via policy related work may help improve impact evidence based behavioral interventions innovative methods increasingly implemented may ability increase public health impact evidence based behavioral interventions prevent disease
objective although graphic cigarette warnings important benefits may aid motivating smoking quit attempts discouraging smoking initiation possible negative consequence might psychological reactance graphic warnings reactance warnings might shaped stereotypical views smokers research examined associations positive negative smoker stereotypes perceptions educational value warnings well affective motivational responses method using cross sectional design young adult smokers nonsmokers completed online questionnaire assessing positive negative smoker stereotypes evaluated series graphic plus text text cigarette warnings perceived new knowledge gained warning understandability warning worry consequences smoking elicited warning discouragement smoking elicited warning results negative smoker stereotypes associated warning perceptions negative stereotypes associated higher levels perceived new knowledge perceived understandability worry discouragement smoking positive smoker stereotypes associated perceived new knowledge neither smoking status warning type moderated relationships smoking stereotypes warning evaluations conclusions focusing enhancing negative smoker portrayals rather reducing positive portrayals may effective antismoking campaigns
according gender role theory individuals confirm expectations associated gender roles rewarded judged expectations deviate parental roles strongly tied gender different expectations behaviors mothers fathers study examined mothers fathers behaviors support discourage positive relationship parent perceived terms acceptability two hundred twent eight parents completed online survey assessing perceptions acceptability negative parental alienating positive coparenting behaviors results provided support hypothesis although parental alienating behaviors rated unacceptable acceptable mothers fathers expectancy violation theory explain parental alienating behaviors viewed negatively mothers exhibit fathers
identification ocular tremor small cohort patients parkinson disease lay somewhat dormant recent report pervasive ocular tremor universal finding large cohort however generally absent cohort age matched healthy subjects reported tremor frequency characteristics similar limb tremor amplitude frequency tremor correlate clinical tremor ratings much controversy ensued origin tremor specifically whether pervasive ocular tremor fundamental feature rather compensatory eye oscillation secondary transmitted head tremor thus measure normal vestibulo ocular reflex mini review summarize evidence case pervasive ocular tremor suggest future experiments may help resolve conflicting opinions
background atopic dermatitis caused complex interplay immune barrier abnormalities murine models essential preclinical assessments new treatments although many models used simulate transcriptomic profiles fully understood comparison models human transcriptomic fingerprint lacking objective sought evaluate transcriptomic profiles common murine models determine relate human skin methods transcriptomic profiling performed using microarrays quantitative pcr biopsy specimens nga flaky tail flg mutated ovalbumin challenged oxazolone challenged injected mice gene expression data patients psoriasis contact dermatitis obtained previous patient cohorts criteria fold change greater false discovery rate less used gene arrays results injected nga oxazolone challenged mice show largest homology human meta analysisderived transcriptome respectively similar human robust also activation seen injected nga mice similar weaker inflammation ovalbumin challenged mice oxazolone challenged mice show centered reaction flaky tail mice demonstrate strong polarization flg mutated mice display filaggrin downregulation without significant inflammation conclusion single murine model fully captures aspects profile instead model reflects different immune barrier disease aspects overall among murine models injected mice best simulate human still translational focus investigation determine model applicable
social scientists long debated best measure pregnancy intentions standard measure relies mothers retrospective reports intentions time conception women already given birth time report resulting children health including vital status may influence mothers responses hypothesize women less likely report deceased children unintended pregnancies may explain cross sectional studies shown children unintended pregnancies higher survival despite fact longitudinal studies shown opposite true using demographic health survey data sub saharan african countries confirm mothers less likely report deceased children resulted unintended pregnancies compared surviving children however opposite true unhealthy children mothers commonly report unhealthy children unintended pregnancies compared healthier children results suggest mothers revise recall intentions traumatic experience child death alter reports face face interview study challenges reliability retrospective reports pregnancy intentions high mortality settings thus also current knowledge levels consequences unintended pregnancies contexts
paper presents new approach develop web server remote systems engineering automatic control laboratories based node easy javascript simulations ejss one hand node javascript development runtime platform distribute non blocking data intensive event driven real time applications across different devices used server hosts laboratory web pages support real time communication controller back end application closes control loop plant front end graphical user interface lets students parametrize observe behavior controllers systems study web browser one ejss powerful intuitive graphical tool develop graphical interactive interfaces simulations used generate javascript html controller front end new strategy deployable different operating system linux mac windows different controller back ends application developed twincat programable logic controller labview virtual instrument lightweight versatile solution set friendly remote control laboratory whose experiments accessed students different types devices pcs laptops tablets smartphones ifac international federation antomatic control hosting elsevier ltd rights reserved
objective immune alterations may play role bipolar disorder etiology however relationship overall immune system functioning mood symptom severity unknown methods two comparative effectiveness trials clinical health outcomes initiatives comparative effectiveness bipolar disorder study bipolar choice lithium treatment moderate dose use study litmus similar trials among patients bipolar disorder study entry white blood cell count bipolar mood symptom severity via montgomery aasberg depression rating scale bipolar inventory symptoms scale assessed performed analysis variance linear regression analyses investigate relationships deviations median white blood cell multinomial regression analysis higher lower white blood cell levels analyses adjusted age gender body mass index smoking diabetes hypertension hyperlipidemia results among bipolar choice participants white blood cell deviation overall bipolar inventory symptoms scale severity increased significantly among men coefficient confidence interval among women coefficient confidence interval interaction analyses showed trend toward greater bipolar inventory symptoms scale symptom severity among men coefficient confidence interval among litmus participants higher deviation median white blood cell showed trend toward higher montgomery aasberg depression rating scale scores among men coefficient confidence interval among women coefficient confidence interval combining litmus bipolar choice montgomery aasberg depression rating scale scores increased significantly among men coefficient confidence interval white blood cell deviation whereas found weak association among women coefficient confidence interval lower higher white blood cell levels correlated greater symptom severity specific symptoms varying according gender conclusion deviations overall immune system marker even within normal white blood cell range correlated mood symptom severity bipolar disorder mostly among males studies warranted investigating whether white blood cell count may predict response mood stabilizing treatment
modern missile systems use infrared imaging tracking target detection algorithms development validation processes missile systems need high fidelity simulations capable stimulating sensors real time infrared image sequences synthetic environment extensible multispectral image generation toolset emit modular software library developed mbda germany generation physics based infrared images real time emit able render radiance images full bit floating point precision using state art computer graphics cards advanced shader programs important functionality infrared image generation toolset simulation thermal shadows may cause matching errors tracking algorithms however real time simulations hardware loop simulations hwil infrared seekers thermal shadows often neglected precomputed require thermal balance calculation four dimensions geometry one dimensional time several hours past paper show novel real time thermal simulation emit thermal simulation capable simulating thermal effects real time environments thermal shadows resulting occlusion direct indirect irradiance conclude paper practical use emit missile hwil simulation
summer relatively complete skeleton juvenile excavated ishkeenickh river cave site ksi hlginx river british columbia canada dating approximately years ago individual likely aged years time death displays osteological features consistent chronic arthropathy striking pathological changes spine bony ankylosis present several cervical thoracic vertebrae lesions also observed ribs ilia femora tibia arthritic conditions juvenile onset ankylosing spondylitis juvenile psoriatic arthritis juvenile onset adult type rheumatoid arthritis along klippel feil syndrome possible aetiologies discussed part differential diagnosis presence post mortem damage well missing bones makes absolute diagnosis disease impossible however lesions present skeleton seem consistent juvenile onset ankylosing spondylitis majority published research diseases appears clinical contexts therefore case study represents unique opportunity observe bony changes occur juvenile idiopathic arthritis context palaeopathology elsevier inc rights reserved
racism racialisation framed threat one ontological security article draws qualitative life history interviews conducted aboriginal people part existing longitudinal health study based city brisbane narratives revealed perceptions racism racialisation significant consideration people asked reflect identity wellbeing time though less frequently overt racism often seen perpetrated within one social circle revealing complicated process engaging contesting rejecting ignoring minimising avoiding defining racism findings highlight agency aboriginal people adapting behaviour avoid minimise dread ontological insecurity
need modernization curricula growing development new technologies support teaching changes business strategy universities poland european union development society response changes department civil environmental engineering poznan university technology new english language specialty master studies construction technology management launched march studies based cooperation student industry university allowing students get know specifics construction industry addition poznan university technology involved mbaic project mba construction aimed common study postgraduates synergy achieved implementation two projects enables possibility educate construction managers capable communication english possessing knowledge regarding innovation construction industry well prepared enter labour market possibility subsequent improvement managerial competences
two studies conducted test predictions multi component model distinctiveness based illusory correlation regarding use episodic evaluative information production phenomenon extending standard paradigm participants presented groups decreasing size exhibiting ratio positive negative behaviours study specifically tested role group size distinctiveness including zero frequency cell design consistent predictions drawn proposed model decreasing group size magnitude effect showed linear increase judgments thought based evaluative information study number changes introduced group assignment task double presentation inclusion decoys allowed rigorous test predicted item specific memory effects addition new multilevel mixed logistic regression approach signal detection type analysis used providing flexible reliable analysis previously decreasing group size effects showed predicted monotonic increase measures group assignment frequencies likability ratings thought dependent evaluative information time measures thought based episodic information free recall group assignment accuracy partly revealed predicted enhanced episodic memory smaller groups negative items also supporting distinctiveness based approach additional analysis revealed pattern results judgments though based evaluative information independent interpersonal variation behavioral memory predicted multi component model contrast predictions competing models results discussed terms implications findings proposed mechanisms illusory correlation elsevier inc rights reserved
hereditary angioedema due inhibitor deficiency inh hae autosomal dominant disease caused mutations serping gene jordanian family including individuals inh hae clinical symptoms studied propositus parents serpingi four mutations leading amino acid substitutions two known polymorphic variants valala valmet others newly described one thrlle located terminal domain inhibitor protein segregates angioedema symptoms family alaval belongs serpin domain derives unaffected father dna additional family members screened mutation target gene individuals heterozygous mutation antigenic functional plasma levels inhibitor normal confirming diagnosis type inh hae angioedema symptoms present subjects carrier allele among subjects carrying variation severe frequent symptoms subjects without mutation family based study provides first evidence multiple amino acid substitutions serpingi could influence inh hae phenotype elsevier ltd rights reserved
mobile social networks msns booming gaining tremendous popularity increasing number communications interactions among users taking advantage users msns make decisions via collecting combining trust information different users hence trust evaluation technology become key requirement network security msns msns however community group structures dynamically changing users may belong multiple communities groups therefore trust evaluation plays critical role inferring trustworthy contacts among users paper innovative trust inference model proposed msns multiple dimensional trust metrics incorporated reflect complexity trust infer trust relations users msns complex communities first construct dynamic implicit social behavioral graphs dynisbg based dynamic complex community group structures propose efficient detection algorithm dynisbg fuzzy degree kappa present multi dimensional fuzzy trust inferring approach involves four metrics static attribute trust factor dynamic behavioral trust factor long term trust evolution factor recommendation based trust opinion moreover obtain recommendation based trust opinion indirect connected users discuss trust aggregation propagation along trust path finally evaluate performance novel approach simulations results show compared existing approaches proposed model provides detailed analysis trust evaluation higher accuracy copyright john wiley sons ltd
lymphedema chronic disabling sequel breast cancer treatment treated lymphatico venous anastomosis lva artificial connections venous lymphatic system performed supermicrosurgically prospective study analyses effect lva quality life prospective study performed november july consecutive patients maastricht university medical centre quality life considered primary outcome lymphedema international classification functioning lymph icf questionnaire used discontinuation compressive stockings arm volume using upper extremity lymphedema index uel index secondary outcomes twenty women early stage breast cancer related lymphedema bcrl included mean age years median bmi mean follow months statistically significant improvement quality life achieved total score quality life domains one year follow discontinuation rate compressive stockings use difference mean relative volume show statistically significant decrease lva early stage bcrl resulted significant improvement quality life high rate stocking discontinuation
paper presents ambient intelligence system designed assisted living system processes audio video data acquired multiple sensors spread environment automatically detect dangerous events generate automatic warning messages paper presents distributed perception infrastructure implemented means open source software middleware called nmm different processing nodes developed cooperate extract high level information environment examples implemented nodes running algorithms people detection face recognition presented experiments novel algorithms people fall detection sound classification localization discussed eventually present successful experiments two test bed scenarios elsevier rights reserved
work presents line energy communication aware scheduling strategy saas applications data centers applications composed various services represented workflows workflow consists tasks related precedence constraints represented directed acyclic graphs dags proposed scheduling strategy combines advantages state art workflow scheduling strategies energy aware independent task scheduling approaches process scheduling consists two phases first phase virtual deadlines individual tasks set central scheduler deadlines determined using novel strategy favors tasks less dependent tasks second phase tasks dynamically assigned computing servers based current load network links servers data center proposed approach called minimum dependencies energy efficient dag mind scheduling implemented greencloud simulator outperforms approaches terms energy efficiency keeping satisfiable level tardiness
nocturnal enuresis underreported symptom profound impact quality life primary objective study investigate prevalence association lower urinary tract symptoms luts validated pelvic floor questionnaire electronic personal assessment questionnaire pelvic floor epaq completed women attending urogynaecology clinic year period association overactive bladder oab stress incontinence sui nocturia assessed using logistic regression subgroup analysis performed women undergoing transvaginal tape tvt ethical approval acquired university sheffield statistical analysis performed using spss version overall prevalence reported cohort women reporting significantly associated oab sui nocturia women undergoing tvt reported preoperatively women reported significantly severe symptoms sui oab sixty percent reported improvement cure postoperatively dependent improvement cure sui presence negative predictor improvement symptoms sui following tvt study provides insight commonly reported symptom women attending urogynaecology clinics knowledge first study implicate stress incontinence important aetiological factor women studies required better understand aetiology adult women relate management outcome
three hundred eighty seven participants general population completed suicidality scale detailed assessment posttraumatic stress daps traumatic events survey tes within prior month adults reported degree suicidal ideation reported active passive suicide attempt multinomial logistic analysis indicated compared nonsuicidal participants age childhood physical abuse childhood sexual abuse childhood emotional abuse associated recent suicide attempts whereas recent suicidal ideation without attempts predicted solely emotional abuse contrast adult sexual physical assaults associated recent suicidality form
paper discusses various aspects models boothroyd dewhurst design assembly dfa methodology integrated product development design curriculum dfa methodology involves team includes concurrent engineering disciplines stakeholders success product design phase manufacturing engineers usually play vital role conceptual design phase order educate next generation manufacturing engineers introduced integrated dfa methodology manufacturing engineering technology met curricula minnesota state university mankato msu detailed description model including advantages disadvantages future directions recommendations included paper
women still underrepresented highest management levels think manager think male phenomenon suggests leadership associated male rather female attributes although styling shown influence evaluation women leadership abilities relevant specific features left remarkably unaddressed xxx skirt pants without jewelry loose hair braid without makeup subjects design participants evaluated woman photograph women makeup pants jewelry rated competent women without makeup skirts without jewelry combination loose hair makeup perceived warmest women loose hair likely hired braids sum even subtle changes styling strong impact women leadership abilities evaluated
background childhood trauma important factor adverse mental health outcomes including depression anxiety purpose present study evaluate hypothesized model describing pathway childhood trauma influence psychiatric symptoms patients depressive disorder model childhood trauma positively associated current depression anxiety symptoms mediated cognitive emotional regulation strategy method patients depressive disorder men women completed beck depression inventory bdi state trait anxiety inventory stai childhood trauma questionnaire ctq cognitive emotion regulation questionnaire cerq divided cognitive emotion regulation strategies adaptive maladaptive strategies using cerq subscore employed structural equation modeling sem simple multiple mediation analyses results indirect effect maladaptive strategies significant relationship overall childhood trauma depression anxiety severity whereas mediation effect adaptive strategies limited depressive symptoms respect specific types trauma maladaptive strategies mediated association emotional abuse current depression anxiety mediation effect adaptive strategies limited emotional neglect limitations study cross sectional design allow establishment causal relationships childhood trauma recall bias may possible conclusions findings support hypothesized model childhood trauma associated adulthood depression anxiety symptoms clinical samples mediated emotion regulation strategies results suggest cognitive emotion dysregulation important factor affecting depression anxiety symptoms patients childhood trauma
paper describes memory architecture improve data transfer storage small satellite main objective design stage architecture find good balance power consumption cost reliability data processing capability variables directly impact important achieve suitable balance low power flash memory selected conjunction faster static random access memory improve performance board computer satellite built buffers flash suitably used improve system performance extensive study timing requirements store data memory done comparison performance different voltage levels required minimum done get balance required speed programming memory power consumption highly modular optimized algorithm proposed data transfer storage easily incorporated real time operating system method save power proposed switching flash memory power saving mode usage required
interest child maltreatment research growing last two decades main approach underlying research relied upon self family reports methods may problematic often require conscious awareness generate socially desirable accurate responses biased parents unrealistic expectations misattributions perceptual errors simultaneously research adapting methods social cognition research attempt access implicit spontaneous processes underlying information processing related parent child interactions exploring parental cognitions emotions may constitute important contributions explain abusive neglectful parenting paper review research child abuse neglect using implicit measures using combinations words related child abuse neglect autonomic affective variables assessed implicit measures conducted systematic review studies examined variables explored type measures used results obtained research reviewed points importance assessing parental representations parent child interactions analyzing differences maltreating non maltreating parents specifically physically abusive parents tend show difficulties recognizing children emotions reveal biases perceptions attributions children behave aggressively research maltreating parents namely neglectful using implicit measures still required elsevier ltd rights reserved
partial oxidation hydrocarbons well controlled conditions opens path higher value chemicals natural gas small exergy losses chemical conversion proceeds internal combustion engine polygeneration process gossler relevant reaction conditions kinetics models sufficiently validated due atypical reaction conditions high equivalence ratios pressures purpose study obtain experimental validation data chemical reaction mechanisms used predict polygeneration processes practical applications case methane processes proceed fuel rich conditions yield primarily syngas study partial oxidation methane investigated equivalence ratio phi shock tube plug flow reactor pfr order cover wide temperature range time resolved mole fractions measured shock heated mixtures similar bar good agreement found experiment models yasunaga burke zhao stable reaction products monitored time flight mass spectrometry bar tubular flow reactor reaction times influence dimethyl ether dme heptane addition methane reactivity conversion investigated additives significantly lower initial reaction temperature producing significant amounts results compared simulations serve validation data development reaction mechanisms atypical reaction conditions good agreement found experiment models species combustion institute published elsevier inc rights reserved
chronic exposure arsenic associated dermatological nondermatological disorders consumption arsenic contaminated drinking water results accumulation arsenic liver spleen kidneys lungs gastrointestinal tract although arsenic cleared sites substantial amount residual arsenic left keratin rich tissues including skin epidemiological studies suggest association skin cancer upon arsenic exposure however mechanism arsenic induced carcinogenesis completely understood developed cell line based model understand molecular mechanisms involved arsenic mediated toxicity carcinogenicity human skin keratinocyte cell line hacat chronically exposed sodium arsenite period months observed increase basal ros levels arsenic exposed cells silac based quantitative proteomics approach resulted identification proteins proteins found overexpressed downregulated twofold upon chronic arsenic exposure analysis revealed arsenic induced overexpression aldo keto reductase family member akrc aldo keto reductase family member akrc glutamate cysteine ligase catalytic subunit gclc nad dehydrogenase quinone nqo among others observed downregulation several members plakin family including periplakin ppl envoplakin evpl involucrin ivl essential terminal differentiation keratinocytes mrm western blot analysis confirmed differential expression several candidate proteins study provides insights molecular alterations upon chronic arsenic exposure skin
performance construction projects criticized many years due low productivity rates cost overruns well significant delays increasing number dissatisfied customers compel practitioners reform conventional practices construction management lean construction emerged result efforts industry however limited number studies demonstrate practical benefits lean construction applications aim paper untangle practical applications lean construction reveal benefits methodology developed compare lean non lean scenarios residential building project means monte carlo simulation simulation models generated regular meetings held construction planning experts research findings demonstrate application lean construction principles potential improve performance projects reducing total project duration expected variation addition study revealed utilization practical lean construction principles may result considerable amount time reduction wall construction plastering activities residential building projects although findings study generalized expected encourage practitioners adopt lean construction principles
development assistive technologies means human machine interface turning one attractive areas today research innovation power consumption signal processing wireless communication focus development systems however devices reached mass market yet system incorporates texas embedded processor wireless communication solutions highly customized analog front ends proof concept technology integrates mcv architecture instrumentation amplifiers analog front end single supply quad amp analog signal processing effective manner development cost effective versatile system impact clinical rehabilitative control applications developing countries thus revolutionizing domain
background objective optimal targets persistent atrial fibrillation persaf ablation still debated atrial regions hosting high dominant frequency hdf believed participate initiation maintenance persaf hence potential targets ablation rotor ablation shown promising initial results currently commercially available system offers capability automatically identify phenomena paper describes integrated software platform combining mapping frequency spectrum phase atrial electrograms aegs help guide persaf ablation clinical cardiac electrophysiological studies methods non contact aegs ensite array jude medical collected analyzed per patient qrst removal aegs divided windows overlap fast fourier transform used identification hdf areas identified maximum centers gravity cgs used track spatiotemporal movement spectral organization measurements estimated hilbert transform used calculate instantaneous phase results system successfully used guide catheter ablation persaf patients mean processing time min adequate comparing normal electrophysiological procedure time similar min conclusions customized software platform capable measuring different forms spatiotemporal aeg analysis implemented used clinical environment guide persaf ablation modular nature platform help electrophysiological studies understanding underlying mechanisms elsevier rights reserved
background sexual behavior young people influenced external factors may increase vulnerability objective describe sexual behavior indicators sexual reproductive health among young people years catalonia identify factors associated sexual risk behaviors methods cross sectional study carried online survey panel population factors associated using condom last sexual intercourse evaluated using multivariate logistic regression models results boys girls reported complete sexual intercourse proportion boys girls reported casual partners respectively boys girls reported contacted partners internet using condom first sexual intercourse showed significant association reporting using condom last sexual intercourse boys girls contacted partners internet associated risky sexual behavior boys used emergency contraception times associated girls conclusions differences sexual behavior young people sex condom use first sexual relationship good predictor condom use last sexual intercourse boys show higher number casual partners girls well higher use internet contact sexual partners
whether long non coding rna lncrna single nucleotide polymorphisms snps affect prognosis acute myeloid leukemia aml remains unknown search association lncrna snps aml outcomes thirty tagsnps five lncrnas genotyped aml patients survival analysis indicated gas significantly associated prognosis aml patients rscc genotype showed higher gas expression peripheral blood mononuclear cells pbmcs harbored longer platelets recovery carriers rst allele vitro study indicated gas promoter harboring rsc allele showed marginally increased reporter gene activity promoter activity increased dose dependent manner moreover gas higher expression predict shorter aml overall survival validated geo gse dataset conclusion polymorphism could increase gas expression interacting might aggravate myelosuppression turn lead poor prognosis aml trail registration number chictr ppc
dose emitted dry powder inhalers dpi inhalation flow dependent varies peak inhalation flow pif patient inhalation maneuver dose emission could also affected parameters inhaled volume initial acceleration rate acim adapted compendial method vitro dpi determinations inhalation profiles replace inhalation square profile generated vacuum pump real life patient inhalation profiles measured copd patients inhaled empty placebo symbicort turbuhaler used identify dose emission characteristics fixed dosed combination budesonide plus formoterol turbuhaler isolate inhalation parameter profiles modified provide profiles study influence identify effect acim fine particle dose total emitted dose mass median aerodynamic diameter significantly influenced pif whereas acim vin small effect results show value vivo methodology provide insight dose patient would inhaled real life use elsevier rights reserved
public discussions harmfulness violent media often held aftermath violent felony time know little whether experiencing real life violence impacts way laypersons perceive evaluate debates virtual violence study provided data indicating real life violence violent video games perceived morally threatening people regard nonviolence important moral value pacifists study hypothesized found pacifists perceive threat presence real life violence especially susceptible scientific political claims indicating violent video games harmful findings line value protection model research psychological consequences threat implications present findings discussed regard better understanding violent video games debate general public
objective automated behavioral state classification benefit next generation implantable epilepsy devices study explored feasibility automated awake slow wave sleep sws classification using wide bandwidth intracranial eeg ieeg patients undergoing evaluation epilepsy surgery approach data seven patients age women underwent intracranial depth electrode implantation ieeg monitoring included spectral power features spanning several frequency bands single electrode used train test support vector machine classifier main results classification accuracy normal tissue epileptic tissue across seven subjects using multiple spectral power features single electrode achieved spectral power features electrodes placed normal temporal neocortex found useful accuracy sleep wake state classification electrodes located normal hippocampus spectral power high frequency band features ripple fast ripple showed comparable performance sws classification best performing berger bands alpha beta low gamma accuracy using single electrode contact single spectral feature significance automated classification wake sws prove useful future implantable epilepsy devices limited computational power memory number electrodes applications include quantifying patient sleep patterns behavioral state dependent detection prediction electrical stimulation therapies
introduction article presents scientific evidence merit telemedicine interventions diagnosis management skin disorders teledermatology published literature impetus work derives high prevalence skin disorders high cost limited availability dermatologists certain areas promise teledermatology address unmet needs area materials methods findings based targeted review scientific studies published january april initial search yielded articles google scholar pubmed review abstracts yielded publications met inclusion criteria analysis evidence organized according following feasibility acceptance intermediate outcomes use service compliance diagnostic treatment concordance accuracy outcomes health improvement problem resolution cost savings special section devoted studies conducted veterans health administration results definitions teledermatology varied across wide spectrum skin disorders technologies diagnostic tools provider types settings patient populations outcome measures included diagnostic concordance treatment plans health conclusions despite complexities sufficient evidence observed consistently supporting effectiveness teledermatology improving accessibility specialty care diagnostic treatment concordance skin care provided primary care physicians also reducing cost one study reported suboptimal clinical results teledermatology patients pigmented skin lesions hand confocal microscopy advanced dermoscopy improved diagnostic accuracy especially rendered experienced teledermatologists
international business research predominantly relied value constructs account influence societal culture notably hofstede cultural dimensions parsimonious value approach assumptions consensus values within nations generality stability cultural patterns behavior increasingly challenged review two promising alternatives constructivist approach centering schemas intersubjectivist approach centering norms evidence demonstrates usefulness accounting international differences behavior managers employees consumers propose situated dynamics framework specifying role values schemas norms accounting cultural differences delineating conditions causal mechanism operative values play important role accounting cultural differences weak situations fewer constraints perceived schemas play important role situational cues increase accessibility relevance norms play important role social evaluation salient directions future research based integrative framework implications measurement culture application discussed
alzheimer disease increasing prevalence significant impact caregivers healthcare system one many physiologic process affected circadian system disruption reflected abnormalities sleep wake cycle interaction bidirectional circadian sleep disruption influencing disease progression understanding bidirectional relationship circadian disruption may allow earlier recognition potential develop dementia well improved targeted approaches therapy therapies including melatonin bright light therapy may advantageous improving sleep circadian rhythms preventing progression disease however unfortunately modalities curative additional research needed improve treatment options individuals
deep brain stimulation dbs nucleus accumbens nac applied attenuate drug relapses animal studies clinical treatments however mechanisms dbs produces therapeutic effects remain largely unknown study first combine manganese enhanced magnetic resonance imaging mri dbs explore effects accumbal dbs relapse pathway rats images suggested dbs produced antidromic activation cortico accumbal afferents verify activating effects dbs expression levels protein encoded immediate early gene fos following dbs measured using immunochemical methods intra shell dbs increased fos expression site stimulation well infralimbic prefrontal cortex increased fos expressing gabaergic interneurons activity consistent previous study demonstrating dbs nac shell attenuated cocaine reinstatement via local activation activation gabaergic interneurons medial prefrontal cortex mpfc examination lidocaine microinjected nac shell block fibers dbs reinstatement test inactivation target fibers attenuated effects dbs reinstatement morphine seeking moreover gaba receptor antagonists administered weakened effect dbs gaba receptor agonists microinjected attenuated reinstatement morphine seeking elsevier inc rights reserved
background objectivemannitol challenge testing established tool clinical asthma diagnosis performed outside specialized respiratory laboratories despite applicability clinical non clinical populations different pre test asthma probabilities differences diagnostic properties well explored study aimed quantify diagnostic utility mannitol challenge testing asthma community cohort symptomatic wheezing subset cohort methodsduring year follow western australian pregnancy raine cohort participants males completed mannitol challenge skin prick testing respiratory health questionnaires reporting wheeze past months included wheezing subset resultsresponsiveness mannitol low sensitivity high specificity identify current asthma complete cohort positive negative predictive values ppv npv respectively within wheezing subset sensitivity specificity remained similar ppv increased npv decreased conclusionour findings support previously reported high specificity good ppv mannitol challenge testing symptomatic wheezing populations highlight need caution interpreting mannitol test results non clinical populations mannitol challenge testing asthma increasingly used non clinical populations outside specialized respiratory laboratories study found high specificity good positive predictive value ppv wheezing population low ppv non clinical population caution required interpreting testing non clinical populations
purpose study identify pattern programme outcomes engineering mathematics subjects direct assessment method used evaluating achievement direct assessments involved study data marks final exams tests quizzes assignments projects subject study first semester students two engineering departments universiti kebangsaan malaysia department mechanical materials engineering department civil engineering suitable measurement tools based course outcomes programme outcomes techniqueswere identified main analysis tool attainment targets performance criteria set relevant data collected analysed compared attainment target target value attained suggestions improvement made implemented finally clustering technique called means clustering technique used identifying pattern exists pos found criterion cluster based mean value could produce great indicator identify different types student achieving value reducing need carry much data collection analysis published elsevier ltd selection peer reviewed responsibility ukm teaching learning congress
background authors investigated patients expectations foot ankle surgery study aimed examine relationships patients preoperative expectations demographic clinical characteristics hypothesized patients disability anxiety depressive symptoms would greater expectations methods adult patients scheduled elective foot ankle surgery orthopaedic foot ankle surgeons screened inclusion months preoperatively patients completed hospital special surgery foot ankle surgery expectations survey addition foot ankle outcome score faos short form patient health questionnaire phq generalized anxiety disorder item scale gad pain visual analog scale vas expectations survey contained expectations categories answer choices ranging expectation complete improvement expected scored higher scores indicating expectations differences expectations relating numerous patient demographic clinical variables assessed total patients average age range years enrolled results expectations scores related age average women expected achieve complete improvement often men variables significantly associated higher expectations scores included nonwhite race use cane assistive device greater medical comorbidity worse function quality life assessed faos subscales physical mental components depressive anxiety symptoms higher pain vas scores associated higher expectations scores expectations conclusions results study may help inform surgeons preoperative discussions patients regarding realistic expectations surgery generally patients worse function disability higher expectations surgery addressing patients expectations preoperatively may help improve ultimate satisfaction surgery level evidence level cross sectional study
background medium long term use antimuscarinics alone combination blocker men enlarged prostate still controversial double blind placebo controlled randomized clinical trial aimed investigate efficacy safety medium long term use tolterodine extended release without tamsulosin patients benign prostate hyperplasia bph larger prostate size methods totally patients age years bph international prostate symptom score ipss quality life qol score total prostate volume enrolled study patients randomized four groups receive tolterodine placebo plus tamsulosin placebo tamsulosin plus tolterodine placebo tolterodine plus tamsulosin placebo tolterodine plus tamsulosin daily weeks ipss total storage voiding subscales qol maximum urinary flow rate max postvoid residual volume pvr collected baseline weeks results compared placebo tolterodine plus tamsulosin significantly improved total ipss storage ipss voiding ipss qol max pvr weeks respectively differences statistically significant however gradual increase pvr urinary aes suggestive urinary retention observed conclusion medium long term use tolterodine plus tamsulosin recommended patients bph enlarged prostate volume
point mutations deletions mitochondrial dna mtdna accumulate tissues aging animals humans basis mitochondrial diseases testosterone synthesis occurs mitochondria leydig cells mitochondrial dysfunction induced experimentally mtdna mutator mice carry proofreading deficient form mtdna polymerase gamma leading mitochondrial dysfunction cells types far studied would therefore expected lead low testosterone levels although mtdna mutator mice showed dramatic reduction testicle weight remaining similar decreases number spermatozoa testosterone levels dna mutator mice unexpectedly fully unchanged leydig cell escape mitochondrial damage complex complex remaining show high levels reactive oxygen species ros production fold increased permeabilized cells demonstrated absence normal mitochondrial function nevertheless within intact cells mitochondrial membrane potential remained high testosterone production maintained implies development compensatory mechanism rescuing mechanism involving electronsfrom pentose phosphate pathway transferred via fold regulated cytochrome cytochrome allowing mitochondrial energization suggested thus leydig cells escape mitochondrial dysfunction via unique rescue pathway pathway bypassing respiratory chain dysfunction may relevance regard mitochondrial disease therapy managing ageing general
development information networking technologies conventional network unable meet demands practical applications network users new network paradigm called software defined networking sdn proposed got public attention decoupling forwarding control planes applying specific protocols sdn greatly reduces cost network management moreover sdn empowers network managers program networks high flexibility however many network security issues regard sdn solved order ensure final success sdn paper undertake sdn security survey focus analyzing sdn security problems reviewing existing countermeasures meanwhile identify future research directions sdn security
background antagonism chemoattractant receptor homologous molecule helper type cells crth protein coupled receptor prostaglandin could beneficial treating allergic disorders present findings efficacy safety tolerability crth antagonist setipiprant participants seasonal allergic rhinitis real life setting weeks methods phase trial phase trial conducted seven centers texas usa mountain cedar pollen season prospective randomized double blind placebo active referenced cetirizine studies phase trial assessed setipiprant versus placebo adult elderly participants phase trial assessed setipiprant adolescent adult elderly participants efficacy assessed using daytime nasal symptom scores dnss night time nasal symptom scores nnss daytime eye symptom scores dess results participants randomized phase trial mean age years randomized phase trial mean age years statistically significant dose related improvement mean change baseline dnss observed weeks setipiprant versus placebo phase trial setipiprant significant effect endpoint phase trial total individual nnss dess symptom scores significantly improved setipiprant versus placebo phase phase trial setipiprant showed favorable safety tolerability profile conclusions phase trial first large clinical study assess crth antagonist seasonal real life setting setipiprant dose related efficacy phase trial confirmed phase setipiprant well tolerated studies
propose deterministic fluid model operation two tandem sip proxies overload conditions using model categorize overload scenarios several classes gaining better understanding sip overload use theory lyapunov system stability characterize stabilizing sip overload control schemes state space representation sip server simple lyapunov function utilized build proportional integral derivative pid controller performing overload control tandem system sip servers proposed pid overload control algorithm evaluated using experiments showing successfully restore throughput close maximum system capacity overload furthermore study effect overload detection lag system stability showing even small delay reacting overload postpone system stabilization multiple minutes elsevier rights reserved
present study examined impact reputation information athletes behavioral responses coaches within naturalistic field based setting using group design male soccer players assigned one three experimental conditions experienced reputation inexperienced reputation reputation prior taking part coaching session delivered unknown coach participants behaviors indicative attention coach instruction effort persistence willingness participate demonstrations video recorded throughout coaching session multivariate analyses variance revealed participants experienced reputation condition exhibited significantly greater attention coach instruction greater effort persistence free practice participants inexperienced reputation condition results related participants willingness participate demonstrations failed yield significant differences results provide evidence support contention athletes use reputation information basis initial expectancies coaches expectancies potential influence athletes behavior coach athlete interactions findings also indicate expectancies based positive information may powerful negatively framed expectancies harnessed coaches means developing effective relationships athletes
aim present study evaluate inflammatory oxidative nitrosative stress blood markers possible predictors multiple sclerosis clinical forms study included patients relapsing remitting rrms progressive clinical forms healthy individuals peripheral blood samples obtained determine serum levels albumin ferritin reactive protein crp total protein lipid hydroperoxide tert butyl hydroperoxide initiated chemiluminescence looh carbonyl protein content advanced oxidation protein products aopp nitric oxide metabolites nox total radical trapping antioxidant parameter trap patients showed higher ferritin looh lower albumin trap aopp nox values controls difference observed crp total protein carbonyl proteins patients controls logistic regression age adjusted ferritin looh showed positive association predictors development respectively albumin trap aopp nox negatively associated respectively moreover logistic regression age adjusted showed patients progressive clinical forms lower albumin higher aopp rrms conclusion ferritin albumin biomarkers looh aopp trap nox predictors diagnosis whereas albumin aopp predictors differentiated rrms progressive clinical forms
objective evaluate effectiveness fetal abdominal circumference guided therapy gestational diabetes gdm outpatient population characterized highly prevalent maternal obesity methods data translational retrospective cohort study come medical records fetal abdominal circumference assessed ultrasound late second trimester sex gestational age specific percentiles assigned taking fetal abdominal circumference percentile marker adequacy fetal growth maternal glucose targets set accordingly loose moderate tight associations mother targets neonatal outcomes small gestational age sga large gestational age lga macrosomia neonatal intensive care unit nicu admission neonatal hypoglycemia assessed using unconditional logistic regression controlling pre gravid body mass index bmi gestational weight gain results consecutive pregnancies complicated gdm neonatal outcomes compared favorably previous randomized trials intensive gdm management importantly adverse outcomes observed less often might expected obese gdm population bmi independent effect neonatal outcomes conclusions ultrasound guided therapy gdm general clinic use limit excess macrosomia lga even population significant maternal obesity
suppress speckle noise effectively become one key problems remote sensing image processing problem also restricts development key technology severely especially military applications overcome shortcoming optimal solution image denoising based sparse representation one one mapping original signal space paper propose novel synthetic aperture radar sar image denoising via sparse representation shearlet domain based continuous cycle spinning first shearlet transform applied noised sar image second new optimal denoising model constructed using sparse representation model based cycle spinning theory finally alternate iteration algorithm used solve optimal denoising model obtain denoised image experimental results show proposed method effectively suppresses speckle noise improves peak signal noise ratio denoising sar image also obviously improves visual effect sar image especially enhancing texture sar image
gene encodes acetyltransferase nat enzyme plays crucial role metabolism many drugs xenobiotics located chromosome one convictive susceptibility loci schizophrenia nat genetic polymorphisms lead various enzyme acetylation phenotypes present study six selected nat exonic single nucleotide polymorphisms genotyped independent case control sample northern chinese han population verify possible association nat schizophrenia three rst six single nucleotide polymorphisms showed significant allele frequency differences case control groups rigorous bonferroni correction one protective fast acetylation haplotype nat two risk slow acetylation haplotypes nat nat discovered associated schizophrenia results indicate nat may susceptibility gene schizophrenia chinese han population risk haplotypes might cause impairment nat metabolizing neurotoxic substances copyright wolters kluwer health inc rights reserved
water infrastructure essential functioning modern cities paper analyses conventional models water infrastructure provision emerging alternatives order identify points reform resistance relationship people technology water cities begins review recent academic contributions understanding relationships people technology nature cities analysis urban infrastructure work andrew feenberg critical philosopher technology presented basis analysing technical discursive elements infrastructure feenberg concept technical code used synthesise key insights analysis urban infrastructure technology devise series critical categories comparing changes currently underway urban water infrastructure provision technical discourse water infrastructure used analyse developments desalination wastewater reuse decentralised non potable supply domestic water efficiency water sensitive urban design ecological sanitation planners designers policy makers concerned sustainability wary technical inevitability desalination potable recycling systems reinstate conventional codes domination control nature separation public concern technical rationality decentralised water systems embody assumptions limits water resources also problematic high users energy reinforcing private right water improving efficiency domestic water using technologies appliances unarguably important achieving sustainability moving beyond water efficiency open discussions water using practices cultural norms holds greater potential transforming water consumption water sensitive urban design widely championed designers planners exemplifying sustainable approach urban nature providing useful foundation moving beyond drainage water supply wastewater technology discourse ecological sanitation filling basic necessity developing cities may part longer term transition sustainability developed cities future eliminating water sanitation recovering resources waste holds potential radically reorder relationships bodies urban spaces nature relationships cities technologies water shifting extent balance falls favour sustainability coming decades determined political discourse well technical innovation elsevier ltd rights reserved
performed case control study investigate associations seven single nucleotide polymorphisms snps acylphosphatase acyp gene breast cancer risk han chinese population cases healthy controls included study snps genotyped using sequenom massarray platform logistic regression adjusted age group body mass index bmi menopause status used evaluate associations various genotypes risk statistical analysis revealed associated decreased risk allele odds ratio confidence interval homozygous dominant additive models addition found associated risk correlated recurrence correlated tumor size sum findings reveal significant associations snps acyp gene risk han chinese population
currently deeply distill potential attributes big data become great challenge structured semi structured unstructured data ssu data unified model structured data refers data resides fixed field within record file including data contained relational databases spreadsheets unstructured data refers data text pictures audio video sources fit relational database semi structured data information reside relational database organizational properties make easier analyze xml html documents paper present literature survey framework namely integrated big data ibd aims exploring approaches constructing universal ibd model including representation storage management computation visual analysis firstly present systematic framework decompose big data analytics four modules next present detailed survey numerous approaches four modules main contributions paper summarized two dimensions first propose novel integrated big data framework unified big data representation storage computation visual analysis second present possible future methods realizing framework reviewing methods paper would like point promising research direction unified investigation application big data
background critical illness associated increased risk fragility fracture loss bone mineral density bmd although impact medication exposures bone anti fracture therapy glucocorticoids time remain unexplored objective study describe association time icu admission post icu administration bone anti fracture therapy glucocorticoids critical illness change bmd methods prospective observational study conducted tertiary hospital icu studied adult patients requiring mechanical ventilation least hours measured bmd annually years icu discharge performed mixed linear modelling describe association time post icu administration anti fracture therapy glucocorticoids annualised change bmd results ninety two participants mean age years least one bmd assessment icu discharge women greater loss spine bmd occurred first year critical illness year year anti fracture therapy use associated reduced loss bmd femur spine men anti fracture glucocorticoid use associated change bmd greater decrease bmd occurred second year critical illness year year conclusions women greater loss spine bmd observed first year critical illness anti fracture therapy use associated increase bmd men bmd loss increased second year critical illness anti fracture therapy may effective intervention prevent bone loss women critical illness
background impact presumed consent donation rates widely debated june greece adopted soft presumed consent law organ tissue donation relatives approval sought prior organ removal aims report knowledge attitudes concerns undergraduate students enrolled three health science disciplines regards organ donation presumed consent methods undergraduate junior senior health science students medical nursing medical laboratory students mls recruited higher education settings thessaly greece dichotomous questions previously used adopted assess knowledge attitudes concerns towards organ donation together questions regarding recent presumed consent legislation results three hundred seventy one students participated study response rate mls carried donor card although groups knew possible leave kidneys transplant death considered well informed likely consider opting followed mls respondents likely refuse organ removal upon death expressing one following views opposing system making lawful take kidneys adult died unless forbidden alive odds ratio confidence interval worrying kidneys removed death believing intact body needed death conclusion health science students soon become healthcare professionals demonstrated limited awareness regards newly reformed organ donation system identified knowledge deficits concerns could far reaching implications terms conveying clear message shaping public stand feasibility effectiveness joint inter professional curriculum organ tissue donation issues across three health science disciplines addressing common themes concerns deserves study
paper presents two different types approach mathematical modeling quadcopter kinematics dynamics first one based equations classical mechanics one derived denavithartenberg formalism lagrangian mechanics obtained models used design control quadcopter motion one rotation axis paper also offers details physical software implementation system tests made
expression levels protein tyrosine kinase acki reported dysregulated various cancers involve oncogenesis progression however expression role ackl osteosarcoma remains unknown study found ack evidently upregulated human osteosarcoma tissues cell lines addition clinical data showed high expression level acki closely associated clinical stage positive distant metastasis negatively correlated overall survival bioinformatics prediction luciferase reporter assay indicated acki direct target mir ackl could downregulated mir mrna protein expression levels moreover ackl expression levels inversely correlated mir osteosarcoma tissues furthermore functional assay showed mir significantly suppressed osteosarcoma progression partially mediated inhibiting ackl expression finally western bolt assay revealed mir regulate akt mmps pathway via ackl osteosarcoma cells conclusion study demonstrated suppression mir osteosarcoma metastasis targeting ackl via akt mmps pathways providing novel strategy diagnosis treatment osteosarcoma patients elsevier inc rights reserved
probation officers large caseloads high levels psychiatric morbidity receive minimal training recognising managing mental health problems national screening procedure mental illness among offenders considered effective study aim develop screening system mental personality disorders using offender assessment system seven screens mental disorder developed using items assessments prisoners alcohol misuse drug dependence antisocial personality disorder psychopathy learning difficulties psychosis severe mood disturbance internal validation showed screens performed well across accuracy estimates prevalence mental disorders identified screens test validation samples similar however psychopathy severe mood disturbance screens may effective screening true negatives screens economical method prioritising mental health needs prison probation population using routinely collected data
background two editions international classification headache disorders ichd diagnostic criteria headache attributed intracranial endovascular procedure published despite studies suggested former practical ichd beta contain major changes moreover far consensus exists regarding characteristics headache intracranial endovascular procedure thus need sound suggestions improve ichd beta diagnostic criteria methods using prospective design identified consecutive patients unruptured intracranial aneurysms uias neuroendovascular treatment january december results total patients enrolled patients ultimately completed month follow procedure five patients pre existing headache experienced marked worsening procedure seven patients without prior headache developed new onset headache post procedurally headaches started within hours mean duration hours headaches moderate severe eligibility events considered headaches caused neuroendovascular procedures according ichd beta diagnostic criteria designation far ideal conclusions cases markedly worsening headaches new onset headaches started within hours persisted longer specified ichd beta diagnostic criteria moreover considering items practical ichd beta diagnostic criteria revised light recent literature reports
technical note extends recent results computational complexity globally minimizing error piecewise affine models related problem minimizing error switching linear regression models particular show one hand problem hard hand admits polynomial time algorithm respect number data points fixed data dimension number modes elsevier ltd rights reserved
present study blast furnace slag granulated form used granular fill overlay soft subgrade soil effectiveness geogrid reinforced granular fill overlay soft subgrade soil assessed small scale model tests laboratory evaluating two parameters bearing capacity ratio bcr reduction factor effect bcr strip footing various lengths geogird layers best performing thickness observed best performing thickness granular fill layer found parametric study included paper parametric study performed observe effect length geogrid layers granular fill overlay soft subgrade soil test results indicate substantial improvement terms increase bearing capacity reduction footing settlement due provision geogrid granular fill overlay soft subgrade soil found ratio gives substantial improvement bcr beyond ratio significant improvement bcr authors published elsevier ltd
excellent engineer training program put forward ministry education plays important role china higher engineering education end based euro american models excellent engineering inorganic nonmetal material engineering specialty paper analyzes achievements problems encountered implementation training program finally explores issues excellent engineer training program proposes strategies employed talent development science engineering colleges
million abortions performed annually united states women presenting abortion care often motivated pregnancy use effective contraception also high risk repeat unintended pregnancy reasons abortion represents optimal time initiate effective contraception strong evidence methods contraception including intrauterine devices contraceptive implant initiated time abortion procedure women ovulate within first month abortion provision contraception delayed women less likely use effective contraception likely repeat unintended pregnancy although methods permanent contraception safely performed time abortion federal state laws often restrict procedures performed concurrently contraceptive counseling provision time abortion important strategies decrease rates unintended pregnancy
past relational databases commonly used technology storing retrieving data allowing easier management retrieval stored information organized set tables however today databases larger size query execution time become long requiring servers bigger capacities purpose paper describe analyze cassandra nosql database using yahoo cloud serving benchmark order better understand execution capabilities various types applications environments different amounts stored data experiments cassandra show good scalability performance results database size number nodes affect
last decades witnessed rapid development green building developments global scale measure deal various challenges related climate change especially environmental issues australia exception unusual extra resources cost required developing green buildings compared conventional buildings justify extra upfront resources required green building developments variety tools developed life cycle assessment life cycle costing two tools used projects order evaluate cost benefits green buildings life cycle perspective however uptake life cycle assessment life cycle costing generally slow construction industry paper presents critical review green building evaluation life cycle perspective particular use life cycle assessment life cycle costing green building evaluation australia reviewed knowledge gap presented future research agenda proposed
new joint mechanical electrical simulation platform motion stage reticle wafer stage introduced step scan lithography platform motion stage control object model represented form state space model extracted finite element model inserted control models built matlab simulink form simulation platform state space model stiff body information also mechanical structure modals motion stage hence compared stiff body model theoretic one much closer actual motion stage simulation example reticle stage control system given step scan lithography time frequent performance indices compared stiff body model state space one respectively showed state space model much adapted meet modeling requirements actual motion stage stiff body one
background thyroid autoimmunity major risk factor gestational thyroid disease recently various risk factors identified including maternal age body mass index bmi parity human chorionic gonadotropin hcg important determinant gestational thyroid function yet unknown extent differences hcg concentration affect risk thyroid disease recently shown thyroperoxidase antibody positivity impairs thyroidal response hcg stimulation may suggest mechanism thyroid autoimmunity acts risk factor thyroid disease objective purpose study determine whether hcg risk factor thyroid disease entities whether recently identified risk factors thyroid disease may influence thyroidal response hcg stimulation methods human chorionic gonadotropin thyrotropin tsh free thyroxine measured pregnant women participating prospective cohort association hcg thyroid disease entities association known risk factors thyroidal response hcg stimulation studied using multivariable linear regression models results higher hcg concentrations associated higher risk subclinical overt hyperthyroidism lower hcg concentrations associated higher risk hypothyroxinemia contrast hcg concentrations associated subclinical hypothyroidism analyses showed women hypothyroxinemia high hcg concentrations still suppressed tsh however women subclinical hypothyroidism high hcg concentrations associated higher higher bmi male fetal sex maternal parity associated lower thyroidal response hcg stimulation conclusions human chorionic gonadotropin associated risk subclinical hyperthyroidism hypothyroxinemia risk subclinical hypothyroidism women hypothyroxinemia normal response thyroidal stimulation hcg abnormal women subclinical hypothyroidism known risk factors thyroid dysfunction bmi parity also male fetal sex associated lower thyroidal response hcg stimulation
paper consider inhomogeneous fifth order nonlinear schrodinger equation variable coefficients describes dynamics site dependent heisenberg ferromagnetic spin chain darboux transformation constructed one two soliton solutions represented virtue lax pair give infinite number conservation laws furthermore graphically analyze influence perturbation terms inhomogeneous parameters soliton propagation interactions perturbation terms found induce phase shift soliton affect soliton amplitude inhomogeneous parameters lead increasing decreasing process soliton amplitude change propagation direction perturbation terms inhomogeneous parameters also affect soliton interactions elsevier rights reserved
two decades conventional wisdom high profile day care cases early suggests modern day witch hunts based false allegations made highly suggestible children era society gripped believe children hysteria author ross cheit refutes conventional wisdom conducting exhaustive examination original data dozens cases bearing witch hunt label concludes witch hunt epidemic finding substantial evidence sexual abuse nearly every case reviewed contradicting assertions made cases calls witch hunt narrative cheit examines legacy witch hunt narrative contends exaggerated claims suggestibility children negative effect credibility children today allege sexually abused writer examines cheit conclusions light experience career prosecutor crimes children well involvement high profile day care case encompassed witch hunt narrative setting record straight cases important sake historical accuracy intellectual honesty also witch hunt narrative unwarranted assertions suggestibility children negative effect society perception credibility bringing public attention fallacies witch hunt narrative shining light questionable tactics used academia support contention children highly suggestible ultimately serve strengthen society ability believe child discloses sexual abuse
although main cause degeneration nigrostriatal dopaminergic projection parkinson disease still controversial many reports suggest excessive inflammatory responses mediated activated microglia induce neurotoxicity nigrostriatal system vivo montelukast plays antiinflammatory role used treat patients asthma addition recent studies reported administration could reduce neuroinflammatory activities showing beneficial effects various neuropathological conditions results suggest montelukast may useful drug alleviate inflammatory responses even though reports showing beneficial effects neurotoxicity nigrostriatal system present study results showed treatment montelukast could protect neurons hydroxydopamine ohda induced neurotoxicity administration significantly attenuated production neurotoxic cytokines tumor necrosis factor alpha tnf alpha interleukin beta beta activated microglia substantia nigra striatum following ohda treatment therefore suggest montelukast used potential inhibitor microglial activation protect neurons adult brain neuroreport copyright wolters kluwer health inc rights reserved
open learning movement opens opportunities collaboration institutions educators learners globally enabling meaningful engagement teaching learning massive open online courses moocs one latest internet revolutions boasting tens hundreds thousands participants worldwide hence present intense interest research education community particularly strong interest investigating added value collaborative features enriching development process well quality result purpose research explore perspectives team based methodology implementation moocs paper present methodology team based development moocs illustrating development process computer programming mooc authors published elsevier open access article license http creativecommons org licenses
era big data cloud distributed key value stores increasingly used building blocks large scale applications comparing traditional relational databases key value stores particularly compelling due low latency excellent scalability many big companies facebook amazon run multiple different applications services top single key value store deployment reduce deployment maintenance complexity well economic cost however every application performance requirement current key value store systems designed serve every application request equally design works well single application accesses key value store good emerging concurrent multi application scenario paper present zht flexible qos quality service fortified distributed key value storage system clouds data centers improves overall throughput order magnitude still satisfies different applications latency requirements qos using dynamic adaptive request batching mechanisms experiment results show new system delivers times higher throughput base solution requests latency requirements satisfied
well known linear space data structures orthogonal range counting worst case optimal query time log loglog give log log space adaptive data structure improves query time log log log log log output count bounds match state art orthogonal range emptiness problem chan give log log space data structure approximate orthogonal range counting compute delta factor approximation count log log time fixed constant delta bounds match state art orthogonal range emptiness problem last consider range selection problem query array involves finding kth least element given subarray problem closely related sided orthogonal range counting recently jorgensen larsen presented linear space adaptive data structure query time log log log log log give new linear space structure improves query time log log log exactly matching lower bound proved jorgensen larsen
paper uses documents generated composiciones tierras cuzco peru discuss economic transformation former heartland inca empire impact spanish administrative policies implemented early diverse social environmental landscapes rural areas lying west cuzco provide range local case studies reveal settlement tribute policies viceroy francisco toledo failed produce sustainable colonial towns christian indians detailed records indigenous land repartition area show gender status based patterns individual allocations well ecological differences landholding communities local records indicate continuing importance inca era community identities local leadership maintaining possession community lands contrast documents related composiciones among private landowners reveal vast inequalities land access well rapid growth demand indigenous labor produce important agrarian commodities argue spanish administrative policies accelerated transformation means production rural cuzco creating peasants instead christian indian subjects
objective protein tyrosine phosphatase ptpb extensively implicated regulation body weight food intake energy expenditure role ptpb appears cell brain region dependent results herein demonstrated chronic high fat feeding enhanced ptpb expression central nucleus amygdala cea rats compared rats chow knocking ptpb oligonucleotide antisense aso decreased expression sufficient improve anorexigenic effect insulin akt signaling cea aso treatment reduces body weight fat mass serum leptin levels food intake also increases energy expenditure without altering ambulatory activity changes explained least part improvement insulin sensitivity cea decreasing npy enhancing oxytocin expression slight decline fasting blood glucose serum insulin levels possibly due leanness rats treated aso surprisingly elevated plus maze test revealed anxiolytic behavior reduction ptpb cea conclusions thus present study highlights deleterious role amygdalar ptpb energy homeostasis obesity states reduction ptpb cea may strategy treatment obesity insulin resistance anxiety disorders elsevier inc rights reserved
last trimester human gestation neurons reach final destination establish long short distance connections due difficulties obtaining functional data age characteristics functional architecture onset sensory thalamocortical connectivity humans remain largely unknown particular unknown extent responses evoked external stimulus general already sensitive certain stimuli present study recorded high density event related potentials erps neonates tested ten weeks term weeks gestational age wga average age wga means syllable discrimination task phonetic change voice change male female voice first observed syllables elicited peaks distinct topographies implying progression sensory input along processing hierarchy second repetition induced decrease amplitude repetition suppression peaks latencies topographies remained stable third change stimulus generated mismatch responses precisely time locked event onset case phonetic change case voice change hierarchical parallel functional architecture therefore able process environmental sounds timely precise fashion well term birth elaborate functional architecture onset extrinsic neural activity suggests specialized areas weakly dependent environment present perisylvian region part genetic endowment human species
autism spectrum disorders asds known characterized restricted repetitive behaviors interests impairments social communication interactions mainly including theory mind tom processes cerebellum emerged one brain regions affected asds cerebellum known influence cerebral cortex activity via cerebello thalamo cortical ctc circuits proposed cerebello cortical disconnection could part underlie autistic symptoms used resting state functional magnetic resonance imaging fmri investigate potential connectivity changes cerebellar dentate nucleus ctc circuit targets may contribute asd pathophysiology comparing asd patients controls found decreased connectivity left cerebral regions known components tom network default mode network implicated specific aspects mentalizing social cognition processing higher order emotional processes pattern overconnectivity also detected left supramodal cerebellar lobules associated default mode network presented fmri data provide evidence functional connectivity dentate nucleus cerebral cortex altered asd patients suggests dysfunction reported within cerebral cortical network typically related social features asds may least partially related impaired interaction cerebellum key cortical social brain regions
children experienced repeated event reports experienced details may inconsistently reported across multiple interviews experiments explored consistency children reports instance repeated event long delay exp age years exp age years exp age years experiments children either experienced activity sessions followed relatively short delay days weeks initial memory test following longer delay months year children reinterviewed memory questions analyzed consistency children memory reports across interviews well forgetting reminiscence accuracy defined narrow broad criteria highly consistent pattern observed across experiments children experienced single event appearing consistent children experienced repeated event conclude inconsistencies across multiple interviews expected children experienced repeated events inconsistencies often reflective accurate different recall
curve number hydrologic parameter used describe stormwater runoff potential drainage areas function land use soil type soil moisture study conducted estimate potential runoff coefficient prc using geographic information system gis based area hydrologic soil group land use slope determine runoff volume soil map study area developed using gps data carried identify soil texture used building soil hydrological groups map unsupervised supervised classifications done landsat etm image generate land use land cover map map reclassified four main classes forest grass shrub cropland bare soil slope map baha generated digital elevation model gis technique used combine previous three maps one map generate prc map annual runoff depth derived based annual rainfall surplus runoff coefficient per pixel using raster calculator tool arcgis indication absence reliable ground measurements rainfall product satisfactorily applied estimate spatial rainfall distribution based values obtained annual runoff generation study area ranged total rainfall rainfall distribution study area shows wise use identifying suitable sites rainwater harvesting constructed dams located higher rainfall areas
despite huge amount work devoted treatment time within relational context relevant temporal phenomena still remain addressed one treatment nearly periodic events events facts occur intervals time repeat periodically meeting occurring twice monday possibly regular times nearly periodic events quite frequent everyday life thus many applicative contexts treatment within relational model quite challenging since involves integrated treatment three aspects number repetitions periodicity iii temporal indeterminacy coping problem requires depth extension current temporal relational database techniques paper introduce new data model new definitions relational algebraic operators coping issues ascertain properties new model algebra emphasis expressiveness representation model reducibility property correctness algebraic operators
cirrus important regulator flow radiant energy earth atmosphere system processes scattering absorption radiation order satisfy urgent requirement accurate retrieval cirrus microphysical properties terahertz wave expected best waveband inverting cirrus particle size ice water path terahertz wavelengths order size typical cirrus particles urgent need establishing stable accurate inversion method new retrieval method particle size ice water path developed based multiple lookup tables spaceborne measurements brightness temperature spectrum ghz ghz ghz ghz ghz channels five parameters derived quantify effects particle size ice water path terahertz radiation spectrum due scattering ice clouds manifested brightness temperature difference brightness temperature difference slope etc retrieve cirrus microphysical parameters weighted least square fit matches modeled parameters used analysis retrieval errors conducted simulated data series results compared retrieved two methods difference method slope method results retrieved multiple lookup table method much closer simulated data series two methods indicated method introduced stable valid method inverting particles ice water path compared errors difference featured method slope featured method retrieval errors reduced particle size ice water path analyses retrieval uncertainties show general uncertainties particle size ice water path vary particle size ice water path ice water path uncertainties mainly spread range particle size uncertainties fluctuate within range words small particle size range uncertainties thick clouds thin clouds however large particle size range uncertainties particles larger smaller results helpful developing terahertz wave remote sensing cirrus microphysical parameter technology moreover also important reference improvement cirrus retrieval accuracy
contemporary approaches child protection dominated individualized forensically focused interventions provide limited scope holistic preventative responses children risk provision support struggling families communities however many jurisdictions frequently shown often public inquiries program reviews investigatory removal approaches failing critically important ways particularly regarding reducing inequities underpin neglect abuse consequently increasing calls public health model protection children although often lack clarity exactly entail yet opportunities learn public health approaches successfully used field injury prevention specifically advocate use haddon matrix provides detailed theoretical practical framework application comprehensive integrated public health model guide intervention program design responses child protection risk factors broad overview application haddon matrix principles methods provided examples program intervention design argued framework provides range interventions necessary address complex social structural factors contributing inequity maltreatment children also provides foundation holistic integrated system prevention intervention contribute system level change address child maltreatment
forty healthy geriatric beagles years initially fed control food day pre feeding period blocked age gender body fat percentage dogs randomly assigned foods experimental food royal canin mature medium breed purina dog chow senior eukanuba senior maintenance month testing period blood chemistry microalbuminuria dexa evaluated changes kidney health body composition day body weight increased dogs fed food tended dogs fed food food lost lean day period dogs fed food also gained fat foods maintained fat addition dogs fed food gained bone mineral content bmc dogs fed food lost dogs fed foods higher blood urea nitrogen bun levels dogs fed food bun creatinine ratio dogs fed foods elevated ratios compared dogs fed food dogs fed food greater percentage animals reduced kidney function indicated microalbuminuria analysis compared dogs fed food conclusion geriatric dogs fed experimental food reduced protein phosphorus showed less progression kidney disease compared commercial geriatric foods addition dogs fed experimental food maintained lean bone mass compared commercial formulations
driven current green building standards previous studies focused much energy efficiency especially operation phase greenhouse gas ghg emission reduction life cycle buildings studies adopted life cycle measure assess ghg emission reduction performance green buildings relationship ghg emission reduction defined green buildings remained unclear authors first develop life cycle ghg measure definitions two state art green buildings located china australia studied present relationship low ghg buildings green buildings found although defined green buildings could better ghg emission reduction performance conventional buildings excellent energy performance sometimes even achieve goal net zero emission building green buildings necessarily indicate low ghg buildings life cycle perspective main reason criteria green building rating tools usually include ghg emission performance perusing sustainability authors suggest life cycle ghg emission reduction taken account evaluation green buildings paper outlines suggestions improving green building rating tools encourage ghg emission reduction performance green buildings elsevier ltd rights reserved
based science technology society sts teaching framework ubiquitous situated learning system developed study using emerging man machine interaction technologies ibeacon quick response codes code teach science technology society aspects smart green buildings teaching experiment statistical analyses conducted explore connections among subjects sex prior knowledge levels quiz scores time spent completing quiz confidence knowledge smart green buildings perceived usefulness system learning interest subjects study junior students department architectural design university taiwan twenty six male female according analysis results use system could help significantly improve students learning results regardless differences prior knowledge levels addition interactive learning provided system accepted students could help students effectively improve test scores knowledge confidence learning interest
due potential applications chaotic system recent years research new type chaotic systems chaotic circuits research hot spot however obvious differences real characteristics simulation results devices operational amplifier paper simplified method circuit improvement proposed achieves results multisim software simulation actual circuit implementation meanwhile feedback synchronization method applied complete actual circuit synchronization control compared original circuit proposed method circuit improvement makes minor changes simulation circuits easy implemented applied chaotic systems
construction management china embraced new practice encompassing evaluation criteria green construction thus greenhouse gas emissions produced construction period overlooked anymore greenhouse gas emissions construction projects evaluated based life cycle assessment theory green construction evaluation management techniques procedure assessing greenhouse gas emissions construction projects developed using unit construction process classifying integrating different components construction projects segregation integration method established calculating greenhouse gas emissions construction project mathematical model framework calculate greenhouse gas emissions construction projects established energy consumption carbon dioxide emissions earthwork foundation work masonry reinforced concrete construction calculated based example commercial building large scale residential complex pingshan new district shenzhen city greenhouse gas emissions calculated equivalent carbon dioxide emissions high rise buildings villas highest unit carbon emissions lcg accoupt carbon dioxide emissions produced construction residential community unit carbon emissions construction entire residential community approximately scientific value paper carbon emissions construction stage residential community quantitatively assessed unit carbon emissions buildings construction used calculate unit energy consumption buildings construction useful realising energy savings therefore provide management guidance reducing energy consumption life cycle building especially consumption construction elsevier ltd rights reserved
purpose study determine whether employees ghana banking sector perceive leaders emotionally intelligent based style leadership study cross sectional nature made use structured questionnaires collect quantitative data questionnaires administered returned comprising males females findings study revealed positive relationship exists transformational leadership emotional intelligence whereas negative relationship found transactional leadership leaders study also noted transformational leaders emotionally intelligent thus recommended attribute associated leader effectiveness made part leadership development organizations
hyperfine interactions useful source information finest structural peculiarities various iron containing proteins essential natural variety structure function relationship normal biomolecules well changes case molecular pathology mossbauer spectroscopy high velocity resolution sensitive probe hyperfine interactions demonstrates advances study various hemoglobins ferritins pharmaceutical products bring new information life sciences
numbers women childbearing age pregestational diabetes mellitus diabetes existing pregnancy increasing primarily patients developing type diabetes younger ages teratogenicity associated hyperglycemia early pregnancy well documented tight glucose control minimizes risk congenital malformation preconception planning essential thus contraception worsen complications diabetes desirable addition contraceptives effective treatment elevated blood glucose levels hypertension dyslipidemia women requires consideration unplanned pregnancy summarized literature aid clinicians choosing individualized treatment minimizes risk case pregnancy occurs maximizes benefit preventing complications diabetes women well controlled diabetes without vascular disease contraceptive methods safe intrauterine devices recommended due minimal effects risk factors diabetic complications lack reliance patient adherence efficacy among insulins insulin analogsinsulin lispro insulin aspart insulin detemiroffer patients greater convenience regular insulin nph insulin safe case unplanned pregnancy noninsulin agents glyburide metformin safest pregnancy many agents pose minimal risk long withdrawn early pregnancy risks benefits angiotensin converting enzyme inhibitors women compelling indications must weighed individually hypertensive patients high risk unplanned pregnancy nifedipine considered due literature supporting safety early pregnancy pravastatin recommended women dyslipidemia using effective contraception reports birth defects statin used early pregnancy humans animals
introduction gastrointestinal motility disorders common clinical settings including esophageal motility disorders gastroesophageal reflux disease functional dyspepsia gastroparesis chronic intestinal pseudo obstruction post operative ileus irritable bowel syndrome diarrhea constipation number drugs developed treating motility disorders currently available emerging electrical stimulation methods may provide new treatment options motility disorders areas covered review gives overview electrical therapies developed motility disorders including gastroesophageal reflux functional dyspepsia gastroparesis intestinal motility disorders constipation various methods gastrointestinal electrical stimulation introduced methods nerve stimulation also described including spinal cord stimulation sacral nerve stimulation potentials electrical therapies obesity also discussed pubmed searched using keywords combinations electrical stimulation spinal cord stimulation sacral nerve stimulation gastrointestinal motility functional gastrointestinal diseases expert commentary electrical stimulation area great interest potential treating motility disorders however development technologies devices suitable stimulation extensive clinical research needed advance field bring electrical therapies bedside
increasingly obese ageing population type diabetes tdm osteoporotic fracture major public health concerns understanding obesity type diabetes modulate fracture risk important identify treat people risk fracture additionally study mechanisms action obesity tdm bone already offered insights may applicable osteoporosis general population available evidence indicates lower risk proximal femur vertebral fracture obese adults however risk fractures proximal humerus femur ankle higher significant number fractures occur obese people bmi positively associated bmd mechanisms association vivo may include increased loading adipokines leptin higher aromatase activity however fat depots could negative effects bone cytokines visceral fat pro resorptive high intramuscular fat content associated poorer muscle function attenuating loading effects increasing falls risk tdm also associated higher bone mineral density bmd increased overall hip fracture risk similarities bone obesity tdm tdm seems additional harmful effects emerging evidence suggests glycation collagen may important factor higher bmd higher fracture risk presents challenges fracture prediction obesity tdm dual energy ray absorptiometry underestimates risk standard clinical risk factors may capture relevant information risk recognised clinicians however limited available evidence suggests osteoporosis treatment reduce fracture risk obesity tdm generally similar efficacy patients
background wound complications following total ankle replacement tar potentially lead devastating consequences aim study compare operative demographic differences patients without major wound problems required operative management hypothesized increased tourniquet operative time would negatively influence wound healing methods identified consecutive series primary tars performed december april whose data prospectively collected identified subset patients required secondary surgery treat major wound complications operative debridement split thickness skin grafting soft tissue reconstruction patients requiring second surgery operative wound debridement compared demographics operative characteristics functional scores see differences existed patients without major wound complications clinical outcomes including secondary procedures implant failure rates recorded results twenty six patients total operative procedures treat major wound issues eighteen patients flaps split thickness skin grafts median time operatively treating wound range months index tar median follow time wound procedure range months compared control group patients major wounds significantly longer mean surgery minutes time trended toward longer median tourniquet time minutes patients without wound complications likely posttraumatic arthritis whereas wound complications likely primary osteoarthritis control group trended toward higher mean bmi failures major wound complication cohort including knee amputations conclusion ankle wounds required operative management high failure rates resulted devastating outcomes find increase major wound complications various risk factors identified studies given data recommend limiting operative time correcting hindfoot midfoot alignment important improving patient functionality survivorship implant thought given staging tar multiple pathologies addressed time surgery limit operative time level evidence level iii retrospective comparative series
building integrated photovoltaic bipv trombe wall system provide heating cooling generate electricity simultaneously precedent studies bipv trombe wall system focused two major types one cells attached glass bipvgtw attached mass wall bipvmtw characterized low thermal bipvgtw electric efficiency bipvmtw study presents blind integrated trombe wall system bipvbtw adopting developed models bipvbtw optimum blind slat angles three seasons summer winter mid term seasons time day investigated comparative assessment three bipv trombe wall systems conducted year round hefei weather conditions terms thermal electrical performance results illustrated annual electricity output bipvbtw system similar bipvgtw system times bipvmtw system bipvgtw system superior bipvbtw bipvmtw systems cooling load reduction using pvbtw pvmtw heating load decreased significantly compared using pvgtw combining electricity generation cooling heating load reduction total electricity saving bipvbtw system higher compared bipvgtw bipvmtw systems emissions reduction bipvbtw system times bipvgtw bipvmtw systems elsevier ltd rights reserved
paper proposes wireless photovoltaic visualization monitoring evaluation fault detection system based stmfdiscovery board bluetooth data transmission matlab simulink platform irradiance cell temperature voltage current devices acquired microcontroller based daq board measurements data transferred host computer bluetooth slave module bluetooth master one built laptop measurement data visually displayed form dashboard matlab simulink environment simultaneously input model theoretical simulation functions evaluation fault detection modules practical working conditions conducted displayed software platform proposed system proved sufficient accuracy confidence functions visualization monitoring evaluation fault detection compared well developed ones proposed system advantages reduce cable hardware configuration integrate visualization monitoring evaluation fault detection solely matlab simulink environment elsevier ltd rights reserved
deleterious effects coherent synchrotron radiation csr phase space energy spread high energy beams accelerator light sources significantly constrain machine design performance paper present simple method preserve beam emittance means using magnetized beams exhibit large aspect ratio transverse dimensions concept based combining finite solenoid field beam generated special optics adapter numerical simulations new type beam source show induced phase space density growth csr notably suppressed less bunch charge work elucidates key parameters needed emittance preservation required field aspect ratio given bunch charge elsevier rights reserved
low power technique static random access memory sram based chip arbitrary waveform generator awg proposed two types analog signal processing applications multiresolution spectrum sensing matched filter sram embedded address generator limit operation sequential access mode awg power consumption awg analyzed according operation modes multiresolution multiwaveform spectrum sensing functions low power technique reduces power sram address generator entire awg supply voltage awg fabricated cmos technology demonstrates chirp signal daubechies wavelet dbc spurious free dynamic range cross correlation factor ideal signals
paper shows example computer simulation hybrid vehicle two different driving modes example shows multiple areas operation simulated hybrid electric vehicle hybrid electric vehicle combined type similar toyota prius cars hybrid electric vehicle two types driving power electric motor internal combustion engine increase level efficiency driving assembly reduce air pollution hybrid electric vehicle combines advantages electric motor drive pollution high available power low speeds advantages engine high dynamic performances little pollution high speeds simulation hybrid electric vehicle simpowersystems simdriveline matlab used
background crizotinib tyrosine kinase inhibitor active alk met ros previously reported crizotinib decreases testosterone male patients detailed etiology effect symptomatic significance effectiveness subsequent testosterone replacement previously reported methods male cancer patients treated crizotinib total testosterone levels measured results compared non crizotinib treated patients albumin sex hormone binding globulin shbg follicle stimulating hormone fsh luteinizing hormone tracked longitudinally subset patients free testosterone levels measured hypogonadal screening questionnaire administered patients receiving subsequent testosterone supplementation assessed symptomatic improvement results mean total testosterone levels lower limit normal lln crizotinib treated patients patients lln compared lln non crizotinib treated patients lln levels albumin shbg bind testosterone declined rapidly crizotinib fsh free testosterone suggesting centrally mediated true hypogonadal effect mean free testosterone levels lln patients lln eighty four percent low free levels low total levels symptoms androgen deficiency five patients low testosterone given testosterone supplementation improvement symptoms coincident increases testosterone lln conclusions symptoms androgen deficiency free total free testosterone levels tracked male patients crizotinib consideration testosterone replacement appropriate cancer american cancer society
sarcoidosis idiopathic noncaseating granulomatous disorder wide systemic involvement encountered widely around world affects sexes races age groups lungs eyes skin organs commonly affected constitutional features weight loss fatigue myalgia common symptoms bone involvement rare reported present effected cases commonly seen hands feet compared long bone involvement extremely rare hereby present case diagnosis sarcoidosis multiple bone involvement emphasizing importance differential diagnosis
background close health disparities indigenous non indigenous australians australian government reduced medication copayments indigenous australians living risk chronic disease patients registered incentive general practitioner assess rates hospitalizations chronic conditions among indigenous australians copayment reductions observational time trend study hospitalizations chronic conditions sensitive medication adherence indigenous persons age years older urban regional remote locations population ranged hospitalizations diabetes asthma chronic obstructive pulmonary disease hypertension heart failure cardiovascular events approximately indigenous persons registered medication copayment incentive first months implementation areas rates incentive uptake exceeding age standardized rate hospitalizations chronic conditions among indigenous australians declined areas average uptake incentive observed non significant reductions age standardized hospitalization rates among indigenous australians rate admission acute conditions pneumonia influenza urinary tract infection pyelonephritis dehydration among non indigenous population found substantially lower rates hospitalizations modest declines though make causal inferences results study observed marked declines hospitalizations chronic conditions among indigenous australians following targeted reductions medication copayments population declines largely limited areas higher uptake copayment incentive observed admissions related acute conditions
global fight terror rapidly changing geopolitical situations raise hot debates urgently needed new designs operational modes efficient low cost jet engine steered jes strike drones expected roles future uclass unmanned carrier launched surveillance strike current ucav unmanned combat air vehicles failed perform needed strike missions role jet engine community rapidly unfolding geopolitical situation reviewed main text appendix
paper describes use symbolic methods applied automatic exploration characterisation analogue mixed signal systems topologies architectures developed methodology acquires desired system requirements algorithm level using hdl description employs modified signal flow graph approach pattern recognition techniques synthesis purposes leading complete characterisation sub blocks automatically generated architecture thus allowing synthesis process move higher levels abstraction proposed methodology provides computer based framework systematic uniform treatment various types data conversion systems including search new conversion algorithms new implementing architectures discussion centered developed methodology high level synthesis data conversion systems linear non linear presented methodology might expanded synthesize analogue structures
propose taxonomy psychopathology based patterns shared causal influences identified review multivariate behavior genetic studies distinguish genetic environmental influences either common multiple dimensions psychopathology unique dimension phenotypic level first order dimensions defined correlations among symptoms correlations among first order dimensions similarly define higher order domains internalizing externalizing psychopathology hypothesize robust phenotypic correlations among first order dimensions reflect hierarchy increasingly specific etiologic influences nonspecific etiologic factors increase risk first order dimensions psychopathology varying degrees general factor psychopathology nonspecific etiologic factors increase risk first order dimensions within specific higher order domain furthermore first order dimension unique causal influences genetic environmental influences common family members tend nonspecific whereas environmental influences unique individual dimension specific posit causal influences psychopathology moderated sex developmental processes causal taxonomy also provides novel framework understanding heterogeneity first order dimension different persons exhibiting similar symptoms may influenced different combinations etiologic influences levels etiologic hierarchy furthermore relate proposed causal taxonomy transdimensional psychobiological processes also impact heterogeneity psychopathology dimension causal taxonomy implies need changes strategies studying etiology psychobiology prevention treatment psychopathology
non volatile memory nvm technologies expected replace dram near future new challenges emerged example nvms slow power consuming writes limited write endurance addition nvms data remanence vulnerability retain data long time powered nvm encryption alleviates vulnerability exacerbates limited endurance increasing number writes memory observe current systems large percentage main memory writes result data shredding operating systems process zeroing physical pages mapping new processes order protect previous processes data paper propose silent shredder repurposes initialization vectors used standard counter mode encryption completely eliminate data shredding writes silent shredder also speeds reading shredded cache lines hence reduces power consumption improves overall performance evaluate design run three powergraph applications multiprogrammed workloads spec suite gem based full system simulator silent shredder eliminates average writes initialization graph construction phases speeds main memory reads times improves number instructions per cycle ipc average finally discuss several use cases including virtual machines data isolation user level large data initialization silent shredder used effectively extra cost
according one ocean idea future global commerce weather jobs food supply recreation national defense goals assumed achieved hand future generation vessels fgvs must equipped proper state art technologies latest research results new concepts one ocean one technologies needed considered stealth technology paper new ability building ships stealthy presented typical proposed prototype plan fgvs presented novel calculation method ship radar cross section rcs presented new closed form formulation electromagnetic scattering derived also method rcs increase reduction ships shaping technique presented according method procedure suggested shaping ship structure real three dimensional model given ship surface effect ship ses primary prototype plan analyzed according procedure modified proposed prototype plan acquired primary proposed prototype plans calculated derived formula effectiveness suggested methods studied way typical proposed prototype fgvs presented results paper help shipbuilders make vessels stealthy possible radars also results help rcs specialists researchers apply novel scattering formulation research activities
challenging optimisation problems abundant areas science industry since scientists responded developing ever diversifying families black box optimisation algorithms latter designed able address optimisation problem requiring quality candidate solution calculated via fitness function specific problem algorithms successful least three properties required effective informed sampling strategy guides generation new candidates basis fitnesses locations previously visited candidates mechanisms ensure efficiency example candidates repeatedly visited iii absence structural bias present would predispose algorithm towards limiting search specific regions solution space first two properties extensively investigated however third little understood rarely explored article provide theoretical empirical analyses contribute understanding structural bias particular state prove theorem concerning dynamics population variance case real valued search spaces flat fitness landscape reveals structural bias arise manifest non uniform clustering population time critically theory predicts structural bias exacerbated independently increasing population size increasing problem difficulty predictions supported empirical analyses reveal two previously unrecognised aspects structural bias would seem vital algorithm designers practitioners respectively increasing population size though ostensibly promoting diversity magnify inherent structural bias effects structural bias apparent faced many classes difficult problems theoretical result also contributes exploitation exploration conundrum optimisation algorithm design suggesting two commonly used approaches enhancing exploration increasing population size increasing disruptiveness search operators quite distinct implications terms structural bias elsevier inc rights reserved
objective despite number studies investigating occurring disorders recently occurring disorders criminal offending studies considered samples forensic mental health services present study conducted investigate relationship mental illness substance use disorders antisocial personality disorder offending method prevalence occurring disorders investigated male offenders contact statewide forensic mental health service victoria australia offense histories severity offending compared among participants diagnosed single mental illness mental illness occurring mental illness substance use occurring disorders plus antisocial personality disorder results majority participants occurring mental substance use disorders significant minority met criteria antisocial personality disorder participants occurring mental illness substance use disorders additional diagnosis antisocial personality disorder responsible serious frequent offending mental illness alone conclusions implications practice forensic mental health services must take account effect occurring disorders clients functioning offending work people psychiatric disabilities occurring substance use disorders must ensure substance disorders addressed help ensure recovery mental illness reduce likelihood offending
purpose evaluate effect rheumatoid arthritis choroid retinal nerve fiber layer rnfl foveal thickness using spectral domain optical coherence tomography oct methods fifty patients forty one healthy volunteers enrolled study subfoveal perifoveal choroidal rnfl foveal thicknesses measured spectral domain oct results mean subfoveal nasal temporal choroidal thicknesses individuals significantly higher control group significant correlation found rheumatoid factor subfoveal temporal choroidal thickness conclusion choroidal thickness patients higher healthy participants choroidal thickening showed positive correlation may indicator systemic vasculitis
objective mounting literature suggests parental monitoring risky peer norms future orientation correlate illicit drug use delinquency however studies investigated constructs simultaneously single statistical model low income african american youth study examined parental monitoring peer norms future orientation primary pathways drug use delinquent behaviors large sample african american urban adolescents methods path model tested direct paths peer norms parental monitoring future orientation drug use delinquency outcomes adjusting potential confounders age socioeconomic sexual orientation sample african american youth results greater scores measures risky peer norms associated heightened risk delinquency effect size twice magnitude compared protective effects future orientation regarding substance use greater perceived risky peer norms correlated increased likelihood substance use standardized effect size times magnitude compared protective effects parental monitoring conclusions findings study suggest interventions targeting risky peer norms among adolescent african american youth may correlate greater impact reductions substance use delinquency exclusively targeting parental monitoring future orientation elsevier ltd rights reserved
introduction agents block inflammatory pathways tumor necrosis factor tnf represented new options treating psoriasis recent years involved regulating cells potent activator keratinocyte proliferation targeting alone may promising treatment approach patients moderate severe chronic plaque psoriasis downregulation cell responses blockade required achieve efficacy patients areas covered authors review provide update tildrakizumab humanized igg monoclonal antibody blocks subunit expert opinion total skin clearance important treatment goal measurable clinically meaningful benefits meeting patient needs total clearance inhibitors obtain specific position crowded psoriasis market hand pasi pasi response achieved tildrakizumab phase iii trials less response achieved inhibitors competitors possibly due less intensive dosing regimen although direct comparisons made without head head randomized clinical trial main advantage tildrakizumab dosed maintenance regimen weeks similar ustekinumab likely encourage adherence aid persistence drug
regarding sustainable schemes green building may considered alternative managing energy use developing countries iran investigating green factors systems aim present study propose new set comprehensive factors suits assessing green buildings evaluate iranian context contribute new aggregated rating tool offices therefore major minor stakeholders defined cover required criteria respecting previous studies expert opinions questionnaire forms defined criteria weighted using multi criteria decision methods consisting analytical hierarchy process weighted harmonic mean shannon entropy iranian green building assessment tool igbt consisting five certification levels developed based weighted factors improve environmental social economic aspects construction process aggregating igbt geographical information system gis multi criteria decision methods practical application proposed tool implemented offices case study municipality mashhad iran purpose spatial database land uses prepared determine certification levels office buildings study area assessment procedure applied gis demonstrated five certified office buildings results designing igbt showed energy efficiency water efficiency total score significant factors assessing green office buildings respect vital circumstances energy water conservation also comparing performance sensitivity five representative green building rating systems confirmed reliability suggested tool based measuring criteria deviations outcomes provide valuable reference policy makers iran also could considerable suggestion future studies elsevier ltd rights reserved
study provides understanding influence outside temperature intuitional buildings urban landscape derive heating cooling degree days buildings identifying appropriate choice balance point temperatures perform multiple linear regression seasonally characterize temperature electricity use relations study reveals considerable differences temperature electricity relationships based building use characteristics addition outside temperature weekday effect large influences electricity consumption buildings summer months greater influence outside temperature electricity consumption followed transition months winter increase one cooling degree day cdd increases daily electricity consumption whereas winter one heating degree day hdd increases daily electricity consumption transition months apply two kinds models project electricity demand projected temperature profiles cases strongly suggest higher electricity demand summer months also transition periods spring fall overall electricity demand increases low emission scenario rcp high emission scenario rcp likely put immense pressure united states electric grid system overall increase energy cost elsevier rights reserved
fibromyalgia common chronic pain condition exerts considerable impact patients daily activities quality life objectives main objective present study evaluate kinematic parameters gait functional performance balance women fibromyalgia syndrome methods study included female patients fibromyalgia years according criteria american college rheumatology well pain free women years gait balance parameters extracted video recordings participants performing several motor tasks non linear dynamic body sway time series also analyzed computing hurst exponent addition functional performance clinical pain obtained using standardized motor tests berg balance scale min walking test timed task romberg balance test self report questionnaires fibromyalgia impact questionnaire results walking speed significantly diminished patients compared vain free controls probably due significant reductions stride length cycle frequency analyses balance also revealed significant differences fibromyalgia pain free controls body sway medial lateral anterior posterior axes several parameters gait balance significantly associated high levels pain depression stiffness anxiety fatigue fibromyalgia conclusion data revealed gait balance severely impaired subjective complaints associated could contribute functional disability patients findings suggest optimal rehabilitation fall prevention fibromyalgia require comprehensive assessment psychological responses pain physical impairments postural control gait
total water samples collected key sampling points july four different depths different sites huaihe river anhui china points monitored parameters water temperature toc spatial variability contamination sources health risk trace elements well river water quality investigated results compared national csepa international usepa drinking water guidelines revealing dominant pollutants water body application different multivariate statistical approaches including correlation matrix factor principal component analysis pca assess origins elements huaihe river identified three source types accounted total variance anthropogenic activities considered contribute much via industrial waste coal combustion vehicle exhaust controlled mixed anthropogenic natural sources natural origins weathered rocks crustal materials cluster analysis used classify sample points three groups water pollution high pollution moderate pollution low pollution reflecting influences tributaries power plants vehicle exhaust agricultural activities respectively results water quality index indicate water huaihe river heavily polluted trace elements approximately water huaihe river unsuitable drinking health risk assessment using hazard quotient index recommended usepa suggests river could cause non carcinogenic harm human health elsevier rights reserved
linear isotropic dielectrics constitute important class linear systems paper proposes novel approach assigning suitable structure describe dependence dynamic behaviour linear dielectrics external parameter influence signal flow graph approach adopted arrive general system structure subcases complex plane representation used establish relationship system structure pattern constant frequency variable parameter plots one one correspondence loci patterns system structure provides rational basis selection suitable system structure
although concrete filled steel tube cft column one composite columns frequently used building construction structural performance economic feasibility good space utilization high potential reduce emissions combining two heterogeneous materials relationship among emissions cost structural parameters green construction buildings cft columns yet carried study optimum design model proposed analyze relationship based analysis founded cft circular sections effective square type terms emissions cost respectively square type advantageous aspect space utilization circular section also consideration various strengths materials emissions cost space utilization columns reduced respectively addition proposed model applied construction story real building analysis optimum designs building circular section advantageous square section regarding emission material cost respectively square section occupied smaller space circular section concluded emission cost space utilization column real building reduced respectively optimum section type material strength elsevier rights reserved
background guidelines published children oncology group recommend screening echocardiograms childhood cancer survivors exposed anthracyclines cardiotoxic radiation study aims assess risk factors cardiac late effects evaluating overall yield screening echocardiograms procedure demographics exposures echocardiogram results abstracted medical records survivors diagnosed years therapy exposed anthracyclines potentially cardiotoxic radiotherapy descriptive statistics logistic regressions performed yield screening echocardiograms calculated results patients screening echocardiograms performed patients abnormal echocardiogram overall yield yields somewhat higher frequently screened patients risk factors abnormal result included anthracycline dose adjusted odds ratio aor confidence interval aor well autologous bone marrow transplant sex race age diagnosis cyclophosphamide exposure statistically significant risk factors patient receiving anthracycline dose without concomitant radiation abnormal echocardiogram conclusions dose dependent synergist anthracycline cardiotoxic radiotherapy risks developing cardiomyopathy confirmed however previously identified risk factors including female sex black race early age diagnosis replicated cohort yields showed weak correlation across frequency categories echocardiographic screening recommendations low risk pediatric patients may warrant evaluation
deletion syndrome microdeletion syndrome high phenotypic variability including somatic disorders like congenital heart disease psychiatric disorders schizophrenia anxiety disorders mood disorders clinical observations suggest many patients suffer severe fatigue however best knowledge previous study investigated potential association fatigue twenty nine patients mean age completed multidimensional fatigue inventory mfi measuring severity fatigue results study group compared published population norms addition cross sectional associations fatigue depression beck depression inventory bdi quality life questionnaire patients examined subscales total mfi scores significantly higher adults approximately study group total mfi score mean norms significant correlation depressive symptoms fatigue found fatigue also significantly associated quality life scores specifically general score psychological health environment first report high levels fatigue adults fatigue frequent complaint age group get necessary attention given association quality life depression severity taking account multisystem nature recommend systematic clinical examination exclude underlying somatic psychiatric causes fatigue wiley periodicals inc
piezoelectric unimorph anemovane proposed analyzed measuring precisely variation wind direction speed proposed anemovane various advantages compared general anemovane detect wind direction fabricated small one anemovane designed shape similar sea urchin use cantilevers imitate prickles projected sea urchin sphere wind blows hit cantilever pressure makes voltage signal piezoelectric unimorph bender simulation proposed system performed using fem software comsol multiphysics multi physics analysis fluid mechanics mechanics electrostatics executed considering real boundary conditions based fem analysis new anemovane new structure control method characteristics fluid piezoelectric unimorph bender comprehended possibility proposed anemovane verified fabrication experiment
study aimed elucidate previously observed associations morningness eveningness seasonality analysing distinct aspects separately morning affect time day preference different seasonal types patterns winter summer etc degree seasonality perceived negative impact seasonality students warsaw completed seasonal pattern assessment questionnaire composite scale morningness winter seasonality related lower unrelated time day preference global seasonality score negatively associated winter seasonality seasonality patterns unrelated time day preference associations remained significant controlling sex age season assessment concluded winter seasonality related low time day preference results indicate considered year round indicator proneness winter seasonality eventually seasonal affective disorder results also suggest time day preference analysed separately future research morningness eveningness
policy path updates common causes network instability leading service disruptions vulnerable intermediate states letter propose reverse update update scheme software defined networking guarantees preserve properties flows transition time prove formal model proposal achieves consistent policy updates transit packets always handled next forwarding hops recent policy main contributions relaxation concept per packet consistency data plane software defined networking policy update scheme proved consistent efficient software defined networking simulator developed validated results simulations show proposed reverse update scheme faster lower overhead current two phase update proposed literature
developing countries facing energy shortage impacts social economic development reliable electrical networks absolutely necessary energy supply unfortunately energy access become major problem developing countries electricity available large cities instance grid reliable additionally power cuts power interruptions electricity rationing frequent causing social tensions work focuses solution lighting electricity rationing use dual voltage led lamp alternative solution expensive kerosene candles dual voltage led lamp give light output vac vac vdc proposed design small electrical grid encompassing dual voltage lamps energy storage solution implemented single family homes renewable energy mini grids well whole cities successful trials carried open university cambridge results presented paper authors published elseiver ltd open access article license
considering value water high cost acquisition distribution goal oriented utilization water resources necessary one problems water resources development developing countries low yield use water irrigation networks downstream dams despite vast investments construction networks iran enough attention paid right method operation guarantees success achievement primary goals networks construction therefore irrigation networks operated experimental methods without scientific planned basis considering complex hydraulics water conveyance distribution open networks extensive infrastructures studying aim determination suitable reliable operation method possible physical tests laboratories experimental approaches mathematical models must utilized present study sobek hydrodynamic model employed provision suitable operation method doroodzan irrigation network located downstream doroodzan dam iran best operation scenario based water distribution assessment indicators offered calibrating model vast study available scenarios present operation method water distributed network steady distribution fixed discharge proposed method water distributed continual distribution variable discharge days provide water requirement present cropping pattern elsevier rights reserved
background legionella spp employ multiple strategies adapt stressful environments including proliferation protective biofilms ability form associations free living amoeba fla aim current study identify legionella spp acanthamoeba spp vermamoeba hartmannella vermiformis naegleria fowleri persist harvested rainwater solar pasteurization treatment system methods pasteurized degrees degrees degrees degrees degrees degrees unpasteurized tank water samples screened legionella spp heterotrophic plate count enumerated additionally ethidium monoazide quantitative polymerase chain reaction ema qpcr utilized quantification viable legionella spp acanthamoeba spp vermiformis fowleri pasteurized degrees degrees degrees degrees unpasteurized tank water samples respectively results legionella spp isolated unpasteurized tank water samples legionella longbeachae frequently isolated followed legionella norrlandica legionella rowbothamii additionally positive correlation recorded heterotrophic plate count number legionella spp detected rho heterotrophic plate count number legionella spp isolated rho tank water samples collected solar pasteurization effective reducing gene copies viable vermiformis log fowleri log lower limit detection temperatures degrees degrees respectively conversely gene copies viable legionella acanthamoeba significantly reduced logs log overall respectively organisms still detected pasteurization degrees conclusions results study indicate acanthamoeba spp primarily acts vector aids survival legionella spp solar pasteurized rainwater organisms detected viable high temperatures degrees
background pressure ulcer formation continues problematic acute care settings especially intensive care units icus institution developed program early mobility icu using specially trained nursing aides goal impact hospital acquired pressure ulcers incidence well factors associated icu deconditioning using specially trained personnel perform acute early mobility interventions methods point mobility scale developed used establish patients highest level activity achievable evaluation mobility team created consisting skin care prevention mobility nurses new category worker called patient mobility assistant level corresponding plan care intervention followed adjusted according patient progress nursing evaluation data collection included type interventions encounter mobility skin assessments new hospital acquired pressure ulcer current mobility level braden score rate ventilator associated pneumonia icu length stay hospital readmission staff also surveyed attitudes toward mobilization perception mobility barriers prepilot postpilot survey planned results year study interval patients enrolled medical intensive care unit micu preimplementation micu hospital acquired pressure ulcer rate year employing mobility team statistically significant decrease micu hospital acquired pressure ulcer rate hospital readmission micu patients also significantly decreased mean micu length stay decreased day safety issues directly indirectly associated interventions conclusions use mobility program resulted decrease recalcitrant patients micu corresponds decrease per patient days definitely statistically clinically significant believe lays groundwork work area shown properly trained nonlicensed professionals safely effectively mobilize patients icu setting represent cost effective way introduce early mobility icu setting elsevier inc rights reserved
recent research shown memory illusions successfully prime children adults performance complex insight based problems compound remote associates tasks crats current research aimed clarify locus priming effects like deese roediger mcdermott drm lists selected prime subsequent crats critical lures also solution words subset crats participants attempted solve unique present research recognition memory tests used participants either primed list study phase memory test phase across two experiments primed problems solved frequently significantly faster unprimed problems moreover participants primed list study phase subsequent solution times rates considerably superior produced participants simply primed test together first results show false memory priming encoding facilitates problem solving children adults
background studies demonstrated economic burden migraines terms quality life health care resource use hru costs exists notable paucity data comparing outcomes among migraineurs nausea vomiting without current study aimed address gap methods retrospective study using data national health wellness survey cross sectional internet based survey respondents self reported migraine without along demographics outcomes including depression patient health questionnaire total score phq sleep problems item total score sleep problems hru number physician visits emergency room visits hospitalizations work productivity activity impairment general health scale wpai associated mean annual costs generalized linear models adjusting covariates assessed burden outcomes results among migraineurs female mean age years old reported experiencing adjusting covariates migraineurs without higher mean phq scores mean sleep problems mean visits frequent among migraineurs without difference translated increase estimated mean costs without mean percentage activity impairment higher migraineurs without migraineurs higher work productivity loss costs without conclusion migraine patients reported worse depression sleep problems activity impairment higher visits without migraine also associated increase mean annual visit costs work productivity loss costs study findings suggest unmet needs current treatment options migraine patients
although dysregulation dopaminergic mesolimbic system generally considered central addiction involvement circuits increasingly appreciated interaction locus coeruleus noradrenergic neurons posterior ventral tegmental area pvta dopaminergic system processing drug triggered reward suggested demonstrated behaving animals herein try tease precise role noradrenergic neurons vta circuit mediating reward reinforcement behavior associated ethanol standard two lever active inactive operant paradigm rats trained self administer ethanol pvta subjected pharmacological intervention intra pvta administration phenylephrine alpha adrenoceptor agonist increased ethanol self administration prazosin disulfiram agents reduce noradrenergic tone produced opposite effects degeneration chloroethyl ethyl bromobenzylamine hydrochloride dsp intraperitoneal route silencing lidocaine muscimol via intra route noradrenergic neurons decreased phenylephrine via intra route reinstated ethanol self administration furthermore lidocaine reduced ethanol self administration effect fully attenuated noradrenaline given directly pvta suggests feedback signals pvta necessary sustain ethanol self infusion activity ethanol self administration significantly increased tyrosine hydroxylase immunoreactivity pvta response blocked dsp pre treatment dopamine receptors localized noradrenergic neurons pre treatment sch intra dampened lever press activity suggest two way communications vta regions essential ethanol triggered reinforcement behavior
internet based tool reporting analysing patient reported outcomes pros developed tool enables merging pros blood test results allows computation treatment responses data may visualized graphical analysis may exported downstream statistical processing aim study investigate whether patients myeloproliferative neoplasms mpns willing able use tool fill questionnaires regularly participants recruited outpatient clinic department haematology roskilde university hospital denmark validated questionnaires used european organisation research treatment cancer quality life questionnaire core myeloproliferative neoplasm symptom assessment form brief fatigue inventory short form health survey questionnaires filled parts per thousand yen months online paper according participant preference regularity questionnaire submission investigated participant acceptance evaluated focus group interviews invited patients accepted participation one hundred seven participants preferred use internet based tool enrolled participants submitted pros regularly parts per thousand yen months focus group interviews revealed internet based tool well accepted internet based approach regular collection pros well accepted high participation rate persistency adherence population mpn patients plasticity platform allows adaptation patients medical conditions
paper genetic algorithm optimization technique proposed find optimal sizing location multi distributed generations electrical networks objective function based linearised model calculate real power losses function power generators method based fundamentally strong coupling active power power flow function voltage angles using multi distributed generation units addressed minimize objective function real power loss taking account capacity transmission line capacity voltage profile constraints order demonstrate effectiveness proposed method applied ieee standard systems set maximum minimum capacity multi units based type renewable energy resources results show linear model combined efficient reducing real power losses finding optimal location size units
origami waterbomb base single vertex bistable origami mechanism unique properties may prove useful variety applications also shows promise test bed smart materials actuation straightforward geometry multiple phases motion ranging simple complex study develops quantitative understanding symmetric waterbomb base kinetic behavior done completing kinematic potential energy analyses understand predict bistable behavior physical prototype constructed tested validate results analyses finite element virtual work analyses based prototype used explore locations stable equilibrium positions force deflection response model results verified comparisons measurements physical prototype resulting models describe waterbomb base behavior provide engineering tool application development
study investigated effects depicted character roles wishful identification main character aggression game enjoyment among players violent video games results showed character roles police gangster athlete significant effect post game aggression however significant association among depicted character roles wishful identification game enjoyment implications terms level aggression identification game character game enjoyment discussed
authors present viewpoint regarding quality data used estimating number preventable hospital deaths united states data derived countries nationalized healthcare system well defined near uniform implementation standards may applicable fragmented noncentralized delivery system found united states although studies evaluating preventable mortality based projections small sample size unlikely observation due chance studies evaluating adverse events precursor preventable mortality much larger sample size also report unacceptably high number events addition although estimates involved adult medicare eligible patients may higher incidence events create bias also capture events taken account mortality occurs hospitalization misdiagnoses also important mitigate adverse events patients whose death imminent medicine moral authority place differing values days weeks years life contention approximately preventable hospital related deaths year united states unreasonable hospital systems united states make investment patient safety recently agency healthcare research quality demonstrated decline adverse events hospitals uniform implementation safety standards takes place healthcare system whole may well lag behind industrialized nations
growing interest scientific community production activated carbon using biochar potential sustainable precursors pyrolyzed biomass wastes physical activation chemical activation main methods applied activation process methods could significantly beneficial effects biochar chemical physical properties make suitable multiple applications including water pollution treatment capture energy storage feedstock different compositions pyrolysis conditions activation parameters biochar significant influences properties resultant activated carbon compared traditional activated carbon activated biochar appears new potential cost effective environmentally friendly carbon materials great application prospect many fields review summarizes information current analysis activated biochar multiple applications optimization understanding also offers new directions development activated biochar elsevier ltd rights reserved
dementia friendly communities dfcs policy initiative aims enable people dementia feel supported included within local community current approaches dfc creation rely stakeholder involvement often requiring volunteer assistance though lack evidence examines reality achieving paper critically assesses challenges strategies achieving stakeholder involvement dfcs evidence base drawn inter agency project funded national health service south england seven dfcs developed steering group partners four part time project workers pws data independent evaluation undertaken first year project analysed semi structured interviews focus group examined pws experiences progress key milestones determined monthly progress forms good news stories locality steering group minutes press releases analysis undertaken using directed content analysis method whereby data content locality matched analytical framework drawn alzheimer society guidance challenges achieving stakeholder involvement identified establishing networks including people representative local community involving people affected dementia gaining commitment organisations strategies achieving stakeholder involvement recognised sustainable approach spreading word sharing ideas highlighting challenges approaches used within communities overcome findings form foundation creation dfc initiatives become embedded within communities stakeholder involvement unpredictable changeable therefore reliance approach questions long term sustainability dfcs must considered future policies designed enhance quality life people affected dementia
high sodium high glucose obesity important risk factors age related diseases cardiovascular disease cvds stroke cancer coupling factor released vascular endothelial cells functions circulating peptide inhibits prostacyclin nitric oxide generation intracellular acidosis high glucose elevates activation protein kinase mitogen activated protein kinase whereas causes type diabetes mellitus resulting high glucose vicious cycle low glucose increases inhibitory factor peptide endogenous inhibitor high salt intake increases nuclear factor kappa signaling whereas induces salt sensitive hypertension salt induced congestive heart failure oral administration vitamin cancels salt induced increase estrogen replacement leads delayed onset induced salt sensitive hypertension rescue cardiac systolic dysfunction contributes onset cvds nutritional regulation shed light understanding preventive strategy mechanisms cvds target therapy elsevier inc rights reserved
natural interaction refers people interacting technology used interact real world everyday life gestures expressions movements etc discovering world looking around manipulating physical objects domain cultural heritage research conducted number directions including personalised information museums interactive exhibits interactive games installations museums museum mobile applications museums presence web museum social applications museums target family groups organize family oriented events programs families choose visit particular museums response leisure needs rarely highlighted work exploits possibility extending usage ami technology thus user experience within leisure spaces provided museums cafeterias museum coffee table augmented physical surface physical objects used accessing information artists creations entertainment children facilitated integration popular games surface result entire family seat around table drink coffee complete visit museum acquiring additional knowledge playing games
obesity known major contributing risk factor knee osteoarthritis also believed obese unicompartmental knee arthroplasty uka patients tend poorer outcome possible early failure purpose study investigate early outcome obese uka patients single institution patients underwent fixed bearing medial uka year included study divided four groups based body mass index bmi control overweight obese severely obese functional outcome assessed using knee society score kss oxford knee score oks short form one way anova bonferroni post hoc test used compare four groups quantitative variables patients study significant difference four bmi groups gender side operated knee functional outcome four groups years comparable mean follow range years revision surgeries identified mean duration initial surgery revision surgery months range patients pre operative bmi influence early outcome uka patients however patients higher bmi relatively lower functional score prior surgery tended younger translate early failure functional improvement similar among four groups
gastrointestinal microbiota plays central role host metabolism bile acids deconjugation dehydroxylation reactions generate unconjugated free bile acids secondary bile acids respectively microbially generated bile acids particularly potent signalling molecules interact host bile acid receptors including farnesoid receptor vitamin receptor tgr receptor trigger cellular responses play essential roles host lipid metabolism electrolyte transport immune regulation perturbations microbial populations gut therefore profoundly alter bile acid profiles host impact upon digestive signalling properties bile acids human superorganism number recent studies clearly demonstrated occurrence microbial disturbances allied alterations host bile acid profiles occur across range disease states intestinal diseases including irritable bowel syndrome inflammatory bowel disease ibd short bowel syndrome clostridium difficile infection exhibit concurrent alterations composition gut microbiota changes host bile acid profiles similarly extraintestinal diseases syndromes asthma obesity may linked aberrant bile acid profiles host focus upon recent studies highlight links alterations gut microbial communities altered bile acid profiles across range diseases asthma ibd karger basel
concept mentoring phenomenon critical teaching learning coming know performing art leadership author article discusses mentoring relationship alternative view humanbecoming lens understanding possibilities ethical nurse practice art mentoring humanbecoming perspective illuminated
background vitro animal studies linked neuroinflammation alzheimer disease pathology studies markers inflammation subjects mild cognitive impairment dementia provided inconsistent results hypothesized distinct blood cerebrospinal fluid csf inflammatory markers associated biomarkers amyloid tau pathology older adults without cognitive impairment beginning cognitive decline objective identify blood based csf neuroinflammation marker signatures associated pathology csf biomarker profile investigate associations inflammation markers csf biomarkers amyloid tau pathology neuronal injury design methods cross sectional analysis performed data older community dwelling adults normal cognition cognitive impairment csf tau ptau panel neuroinflammatory markers csf serum quantified least absolute shrinkage selection operator lasso regression applied determine reference model best predicts csf biomarker profile defined priori tau beta ratio compared second model included inflammatory markers either serum csf addition correlations inflammatory markers csf beta tau tau levels assessed results forty two subjects met criteria csf biomarker profile best predictive models included serum csf neuroinflammatory markers related cytokine mediated inflammation vascular injury angiogenesis models improved accuracy predict biomarker profile compared reference model analyses separately performed subgroup participants cognitive impairment adding serum csf neuroinflammation markers also improved accuracy diagnosis pathology results none inflammatory markers correlated csf beta levels six csf markers mcp vegfr sicam svcam vegf correlated csf tau tau levels associations remained significant controlling age sex cognitive impairment apoe epsilon status conclusions identified serum csf neuroinflammation biomarker signatures improve accuracy classification pathology older adults results suggest inflammation vascular injury angiogenesis reflected csf markers closely related cerebral tau pathology elsevier inc rights reserved
current study tested whether participants played violent video game vvg would exhibit increased aggressive inclinations relative played non violent video game nvg participants randomly assigned play vvg nvg prior presumably interacting another non existent participant measured participants aggressive inclinations participants reported many pins would like stick voodoo doll representing interaction partner participants reported likely would actually harm interaction partner detect differences conditions several outcomes amount aggressive inclinations displayed interaction number pins participants chose stick representation interaction partner participants self reported likelihood would harm interaction partner thus hypothesis playing vvg would increase aggressive inclinations supported study exploratory analyses revealed associations participants self reported likelihood aggress perceptions game frustrating difficult gender higher levels pin selection participants self identification gamer lower levels pin selection elsevier inc rights reserved
brief presents integrated optimization framework battery sizing charging road power management plug hybrid electric vehicles framework utilizes convex programming assess interactions three optimal design control tasks objective minimize carbon dioxide emissions board internal combustion engine grid generation plants providing electrical recharge power impacts varying daily grid trajectories optimal battery size charging power management algorithms analyzed find level grid emissions significantly impact nature emission optimal road power management also observe road power management strategy important design task minimizing emissions variety comparative studies
indigenous circumpolar populations experienced profound transitions lifeways past half century result economic development although positive aspects social transformation circumpolar groups today triple burden disease modestly elevated infectious disease level elevated increasing burden chronic conditions obesity cardiovascular disease high rates mental health related challenges health contemporary circumpolar populations easily characterized dramatic regional differences stem socioeconomic disparities among nonindigenous groups individual population histories lifestyle factors environmental pollution underlying biological variation overall health well range excellent among sami sweden norway extremely poor among marginalized native populations northern russia circumpolar groups today threatened continued regional economic development pollution also uniquely vulnerable global climate change
information security achieved using cryptography steganography combination data firstly encrypted using available cryptography techniques hid hiding medium recently famous genomic dna introduced hiding medium known dna steganography due notable ability hide huge data sets high level randomness hence security despite numerous cryptography techniques knowledge vigenere cipher dna based playfair cipher combined dna steganography keeps space investigation techniques coming new improvements paper presents comprehensive analysis dna based playfair vigenere rsa aes ciphers combined dna hiding technique conducted analysis reports performance diversity combined technique terms security speed hiding capacity addition key size data size moreover paper proposes modification current combined dna based playfair cipher technique makes simple fast also provides significantly higher hiding capacity security conducted extensive experimental studies confirm outstanding performance comparison discussed combined techniques elsevier ireland ltd rights reserved
background researchers involved biomedical community based projects rarely seek perspectives community fieldworkers foot soldiers projects understanding effect biomedical research community based field workers could identify benefits shortfalls may crucial success community based studies present study explored perceptions community based field workers effect etiology risk factors interactions enteric infections malnutrition consequences child health development project mal south africa tangible intangible capital together comprise sustainable livelihoods methods study conducted dzimauli community limpopo province south africa january february sustainable livelihoods framework used query community based field workers perspectives tangible assets income physical assets intangible assets social capital confidence skills data collected twenty one individual depth interviews one focus group discussion data analysed using thematic content analysis approach supported atlas version software results field workers indicated benefitted mal south africa project benefits included intangible assets acquisition knowledge skills stronger social capital personal development additionally indicated mal south africa provided tangible assets increased income physical assets observations obtained focus group discussion community based leaders concurred findings depth interviews additionally field workers expressed desire training public relations communication problem solving confidence building conclusions mal south africa biomedical research project positive effects tangible intangible assets compose sustainable livelihoods community based fieldworkers however field workers expressed need acquire social skills enable carry duties efficiently
river discharge critical component understanding hydrological processes sustainable management water resources importance discharge observation increased due potential extreme variation resulting projected climate change stronger variability precipitation temperature large basins however inherent difficulties ground based observations decreasing number gauge stations hinder accurate measurement global river discharge spatio temporal variations various remote sensing methods examined alternatives however require ground measurements convert proxy measurements actual river discharge study estimate discharge obidos station mouth amazon basin using water storage variations derived grace gravity data without relying auxiliary ground observations extract water mass signal along main stem river applying empirical orthogonal function eof water storage variations basin relative water storage variations along main stem derived eof decomposition highly correlated situ discharge obidos however high water season grace based discharge estimated larger situ observations difference particularly significant extreme flood season argue situ river discharge underestimated due missed water volume flow detouring around obidos gauge station high flow event net river discharge amazon basin atlantic ocean also estimated annual discharge larger obidos particular river discharge atlantic oceans estimated gton elsevier inc rights reserved
understanding intestinal enteropathogens cause acute chronic alterations direct animal human health perspectives significant advances made field studies focusing dynamic crosstalk intestinal protozoan parasite model giardia duodenalis host intestinal mucosa concept intestinal barrier function highest importance context many gastrointestinal diseases infectious enteritis inflammatory bowel disease post infectious gastrointestinal disorders crucial function relies biotic abiotic components first commensal microbiota organized biofilm overlaying mucus layer finally tightly structured intestinal epithelium herein review multiple strategies used giardia parasite circumvent components summarize known discuss preliminary observations suggesting enteropathogen directly indirectly impairs commensal microbiota biofilm architecture disrupts mucus layer damages host epithelium physiology survival
results presented study changes characteristics pore structure gas permeability mechanical properties materials upa upa based knitted fabric fillers textiles materials different structures based carbon fibers obtained using oxidized polyacrylonitrile different grades viscose changes characteristics examined relation degree pre compression materials length time undergo compaction pyrolytic carbon graphite
introduction well documented black hispanic dialysis patients overall lower risks death white dialysis patients little known whether lower risks observed cause specific deaths additionally recent research reported younger black patients higher risk death source unclear therefore study examined cause specific deaths among dialysis patients race ethnicity age methods national study included incident dialysis patients united states renal data system five cause specific mortality rates including cardiovascular cvd infection malignancy known causes miscellaneous unknown compared across blacks hispanics whites overall stratified age groups findings multiple adjustments hispanic patients lowest risk mortality every major cause almost ages compared whites blacks lower risk death cvd malignancy miscellaneous causes age groups infection fact blacks higher risk infection death whites ages years years years partially attributed higher prevalence aids nephropathy race ethnicity two thirds infection deaths due non dialysis related infections discussion hispanics lowest risk major cause death blacks less likely die whites causes except infection previously reported higher overall mortality rate younger blacks attributed two fold higher infection mortality mostly non dialysis related suggesting new direction improve overall health status research greatly needed determine social biological factors account survival gap dialysis among different racial ethnic groups
hormone oxytocin plays important role attachment formation bonding humans domestic dogs recent research led increased interest potential applications intranasal oxytocin aid treatment psychological disorders humans studies explored effects intranasally administered oxytocin social cognition social bonding dogs alternative applications yet explored treatment behavioural problems species one potentially important application intranasal oxytocin dogs could treatment separation anxiety common attachment disorder dogs provide overview known role oxytocin human dog bond canine separation anxiety discuss considerations future research looking integrate oxytocin behavioural treatment based recent findings human dog literature
years research shown people favor members ingroup impressions attitudes behaviors propose people also form different mental images minimal ingroup outgroup members test hypothesis differences mental images contribute well established biases arise minimal group categorization study participants assigned groups using classic minimal group paradigm next reverse correlation image classification procedure used create visual renderings ingroup outgroup face representations subsequently sample naive face generation stage rated faces series trait dimensions results indicated ingroup face significantly likely outgroup face elicit favorable impressions trusting caring intelligent attractive extending finding study revealed ingroup face representations elicited favorable implicitly measured attitudes outgroup representations study showed ingroup faces trusted outgroup faces economic game finally study demonstrated facial physiognomy associated trustworthiness closely resembled facial structure average ingroup outgroup face representation together studies suggest minimal group distinctions elicit different mental representations visual bias sufficient elicit ingroup favoritism impressions attitudes behaviors
paper discusses design construction operation low cost small farm scale digester cattle wastes used biogas produced contained volume production quantities qualities measured period six months summer winter biogas used two different systems instant gas water heater used generate hot water farm use modified piston engine driving electrical generator one phase output fuelled directly gas operation systems satisfactory unit used demonstrate technology potential users mostly farm owners
backgroundin parent study analysis patients type diabetes received lixisenatide breakfast main meal day substudy designed examine effect lixisenatide administered breakfast main meal day continuously assessed hour patient glucose profiles methodsa subset patients parent study underwent day periods continuous glucose monitoring cgm start end week study ambulatory glucose profile analysis used measure changes time detailed aspects glucose profiles breakfast group consumed standardized meal cgm periods determine change hour glycemic response resultsdata available patients substudy original breakfast group main meal group baseline end study mean standard deviation total glucose exposure decreased breakfast group main meal group patients included substudy hba decreased approximately groups mean standard deviation hour total glucose exposure fell baseline conclusionsthis analysis demonstrates lixisenatide beneficial effects components hour glucose profile endure beyond meal administered continuous glucose monitoring analysis detects changes captured using hba alone
individuals convinced act climate change widely assumed emphasizing personal responsibility climate change effective increasing pro climate behavior whereas collectively framing causes climate change diffuses responsibility dampens incentive individual action observe opposite result find across three experiments emphasizing collective responsibility causes climate change increases pro climate monetary donations approximately environmental group members general public highlighting collective responsibility amplifies intent reduce future carbon emissions contrast focusing personal responsibility climate change significantly alter donations climate change advocacy intent future pro climate behavior effects replicate persist multiple days treatment
reduced graphene oxide rgo dispersed nanofluids prepared irradiating graphene oxide water one light different times ray photoelectron spectroscopy xps analyses verified reduction rgo irradiation indicated reduction degree increased time zeta potential measurements suggested rgo water nanofluids obtained irradiation time less keep stable elevated temperatures transmittance rgo water nanofluids quite less water one indicating change rgo greatly enhanced optical absorption rgo water nanofluid obtained irradiation possessed higher thermal conductivity less specific heat water one good stability along high optical absorption thermal conductivity make rgo water nanofluid exhibited superior photo thermal conversion efficiency water graphene water ones loading reached degrees degrees revealed rgo water nanofluid prepared water one shows greater promise use working fluid low temperature direct absorption solar collectors
automatic system based thermoelectric cooler tec microfan microcontroller first applied thermal management high power light emitting diodes leds hardware composed microcontroller control core type thermocouples acquisition devices tec microfan heatsink cooling vehicles experiment confirms leds substrate temperature controlled effectively indicates led chips operating reliably specifically high temperature environments degrees system automatically drop low set temperature degrees due thermoelectric effect driven tec heat transfer analysis shows maximum led power cooled system total power consumption automatic cooling system automatic cooling system high cooling efficiency
symptoms sleep apnea sleep fragmentation oxygen desaturation might risk factors subsequent mood disorder associations sleep apnea remain unclear nationwide population based study thus aimed identify risk patients without sleep apnea cohort study used data national health insurance database total patients diagnosed sleep apnea evaluated matched non sleep apnea enrollees included comparison cohort subjects followed cox proportional hazard ratio used investigate relationship sleep apnea controlling covariates comorbidities sleep apnea patients sleep apnea diagnosed follow period comparison individuals without antecedent sleep apnea adjusting selected factors comorbidities found patients sleep apnea fold greater risk comparisons three subcategories major depressive disorder bipolar disorder unspecified sleep apnea highest predisposing risk respect major depressive disorder adjusted bipolar disorder adjusted greater likelihood manifesting patients history sleep apnea health professionals thus advised carefully monitor psychological impacts sleep apnea
paper discusses multi signal flow graph model testability analysis method based model modeling process multi signal model dependency matrix generation method failure test details testability analysis illustrated use several examples results got testability analysis also validated demonstrated testability analysis method based multi signal model easy implemented computer aided analysis helps develop testability analysis software tool future
ontology engineering field key aspects real world business contexts normally taken account one crucial aspects planning scheduling software engineering practitioners use different approaches tools planning scheduling software development projects whereas counterparts ontology engineering encounter many problems create project plans schedules bridge gap created method tool latter called gontt systematizing scheduling ontology development projects context neon methodology paper try explain methodological pillars method tool grounded elsevier rights reserved
objectives many existing healthcare interventions diffused modern evidence based standards clinical cost effectiveness disinvestment ineffective inappropriately applied practices growing priority international health policy improved quality care sustainability resource allocation australian policy stakeholders canvassed assess perspectives challenges nature disinvestment methods senior health policy stakeholders australia criterion snow ball sampled identify opinion leaders participants primed potential disinvestment case study took part individual semistructured interviews focused mechanisms challenges within health policy support disinvestment interviews taped transcribed thematic analysis participant comments identified results ten stakeholders interviewed saturation reached three primary themes identified current focus assessment new emerging health technologies practices lack attention toward existing practices due resource limitations methodological complexity participants considered parallel model australia current assessment process new medical technologies best positioned facilitate disinvestment advance disinvestment agenda requires explicit focus potential cost savings coupled improved quality care iii support financial collaborative needed research advancement methodological underpinnings associated health technology assessment disinvestment specifically conclusions exploratory study stakeholders support notion systematic policy approaches disinvestment improve equity efficiency quality safety health care well sustainability resource allocation
paper design event driven usercentric middleware monitoring managing energy consumption public buildings spaces presented main purpose increase energy efficiency buildings public spaces thus reducing consumption achieve proposed service oriented middleware designed event based also exploiting user behavior patterns people live work buildings furthermore allows easy integration heterogeneous technologies order enable hardwareindependent interoperability moreover heating ventilation air conditioning hvac control strategy developed whole infrastructure deployed real world case study consisting historical building finally results presented discussed
irritable bowel syndrome ibs common therapies unsatisfactory food often suspected cause patients diagnostic procedures apart allergy testing limited based hypothesis non celiac wheat sensitivity subgroup ibs patients tested long term response gluten free diet gfd investigated hla expression diagnostic marker diarrhea dominant ibs mixed type ibs ibs response gfd served reference test hla expression determined index test patients classified responders reported complete considerable relief ibs symptoms least weeks month period gluten free diet established questionnaires ibs quality life ibs qol ibs symptom severity scale ibs sss european quality life dimensions used secondary outcome measures thirty five patients finished study responders classified hla expression specificity sensitivity responders showed improvement quality life symptom scores year follow responders non responders still gfd reported symptom relief using strict criteria recommended ibs studies one third patients ibs ibs wheat sensitive similar proportion ibs types expression hla useful diagnostic marker long term adherence gfd high sustain symptomatic improvement
frequency severity physical abuse influences children outcomes yet little theory based research explored predicts course study examined potential role social information processing sip factors course abuse mothers histories perpetrating physical abuse completed measures sip frequency severity mother perpetrated physical abuse collected child protection services records poorer problem solving capacities significantly related greater frequency physical abuse hostile attributions toward children positively associated abuse severity controlling demographics occurrence neglect sip factors together accounted significant proportion variance frequency physical abuse severity exception unrealistic expectations preliminary evidence supported link maternal sip course abuse perpetration future research directions implications intervention discussed
background philadelphia chromosome negative myeloproliferative neoplasms mpn myelofibrosis polycythemia vera essential thrombocythemia negatively affect patient quality life qol associated increased risk mortality methods mpn landmark survey conducted may july patients active management united states survey assessed respondent perceptions disease burden treatment management included questions overall disease burden qol activities daily living work productivity outcomes analyzed calculated respondent reported prognostic risk score symptom severity quartile results survey completed respondents median respondent age mpn subtypes ranged years median disease duration years many respondents reported experienced mpn related symptoms greater similar year diagnosis respondents also reported mpn related symptoms reduced qol including respondents low prognostic risk scores low symptom severity many respondents including low prognostic risk score reported mpn caused cancel planned activities call sick work least preceding days cancel planned activities call sick conclusions findings mpn landmark survey support previous research symptom burden experienced patients mpns first detail challenges patients mpns experience related reductions activities daily living work productivity
background rate lost time sprains strains private nursing homes three times national average back injuries almost four times national average ohio bureau workers compensation bwc sponsored interventions preferentially promoted nursing homes including training consultation grants equipment purchases methods study evaluated impact bwc interventions back injury claim rates using bwc data claims interventions employer payroll ohio nursing homes using poisson regression subset nursing homes analyzed detailed data allowed estimation impact staffing levels resident acuity claim rates costs interventions compared associated savings claim costs results equipment purchase per nursing home worker associated reduction back injury rate assuming equipment lift years translates estimated reduction claim costs per worker present value discount rate applied results training courses equivocal receiving median hours significant reduction claim rates injury rates generally decline consultation independent equipment purchases although possible confounding misclassification bias due non random management participation clouds interpretation nursing homes available data resident acuity modestly associated back injury risk injury rate increased resident staff ratio acting three terms additional resident per staff member ratio alone nhs expenditure per resident care worker equivalent per employee model also associated reduction injury rate however resident staff ratio greater expenditure associated reduction back claim costs years per employee present value discount rate conclusions expenditures ergonomic equipment nursing homes ohio bwc associated fewer worker injuries reductions claim costs similar magnitude expenditures estimated benefits costs also need considered assessing full health financial impacts ind med wiley liss inc
letter presents gait classification technique identification individuals different gait patterns using simulated micro doppler radar remote sensing data proposed feature parameters classification principal components velocities extracted via micro doppler radar signals generated using motion capture based kinematic data distinct differences found proposed parameters among three groups subjects different gait patterns healthy young elderly adults elderly adults history falls elderly fallers
paper concerns dynamical decoupling feed forward control magnetically levitated planar actuators mlpas moving coils moving stage center mass deviates geometric center based direct wrench current decoupling factors affect continuity current emphatically analyzed stable current control propulsion works converted newton euler dynamic equation inverting system dynamics degrees freedom dof individual control realized system simplified mimo siso based decoupling acceleration feed forward controller pid control designed studying coupling parameter relating feed forward inputs white noise acceleration amplification coefficient achieved pid parameters optimized based comparing actual variance minimum achievable variance last simulation results indicate feed forward compound controller applying mlpas system better performance general pid controller
paper multi scale numerical simulation method used simulate dynamic behaviors nano void metal shock loading method couples molecular dynamics method used local defect domain finite element method used globally using bridge scale function based calculated strain field temperature field atom positions reveal collapse nano void depends yield strength materials shock loading strength compression process void main reason formation local hot spot meanwhile dislocation hot spot induced void collapse lead easy formation local adiabatic shear band
background transition late adolescence early adulthood years represents time exploration self discovery many young people often associated experimentation substance use vocational students particular report high substance use thus aim study examine patterns trajectories substance use behavior methods two occasions interval months investigated students years male vocational schools seven german federal states identified classes substance use trajectories via latent transition analysis controlling gender age socio economic status additionally investigated work related job demands stress satisfaction psychopathological depressive symptoms predictors substance use via multinomial regressions results found three latent stages substance use low use baseline follow mainly alcohol use polysubstance use time alcohol users baseline transitioned polysubstance use follow smaller transition rates stages compared low use polysubstance use follow predicted high job stress aor baseline conclusions high alcohol use associated bidirectional transitions young adults hence future research needs identify mechanisms change identify protective factors regarding vocational practice early stress management seems viable path prevent polysubstance use vocational students elsevier ltd rights reserved
non vitamin antagonist oral anticoagulants noacs favorable benefit risk profile compared vitamin antagonists however lack specific reversal agents made management patients receiving long term treatment noacs problematic emergency situations major bleeding events urgent procedures idarucizumab fully humanized fab antibody fragment binds specifically high affinity dabigatran recently approved use adult patients treated dabigatran rapid reversal anticoagulant effect required clinical experience idarucizumab currently limited report real life clinical cases idarucizumab used multidisciplinary consultation variety emergency situations including severe postoperative bleeding emergency high bleeding risk surgery hip spine surgery neurosurgery invasive diagnostic testing lumbar puncture intracranial bleeding pre pontine subarachnoid hemorrhage lobar intracerebral hemorrhage thrombolysis recombinant tissue plasminogen activator acute ischemic stroke case series illustrates role idarucizumab improving patient safety rare emergency situations requiring rapid reversal anticoagulant effect dabigatran highlighting importance information education availability appropriate use recently approved specific reversal agent
charge sharing fractional collection charge cloud generated detector two adjacent pixels may lead excessive inefficient registration hits comparing number impinging photons depending discrimination thresholds set typical photon counting pixel detector problems particularly exposed fine pixel sizes thick planar detectors presence charge sharing one limiting factors discourages decreasing sizes pixels photon counting mode ray radiation imaging systems currently different approaches tackling charge sharing problem exist medipixrx pixie minivipic pix general idea first reconstruct entire signal adjacent pixels secondly allocate hit single pixel paper focuses latter part process comparison different hit allocation algorithms affect spatial accuracy false registration missed hit probability different hit allocation algorithms simulated including standard photon counting full signal reconstruction algorithm also novel approach based detection patterns significantly limited analog signal processing proposed characterized
change points abrupt variations time series data abrupt changes may represent transitions occur states detection change points useful modelling prediction time series found application areas medical condition monitoring climate change detection speech image analysis human activity analysis survey article enumerates categorizes compares many methods proposed detect change points time series methods examined include supervised unsupervised algorithms introduced evaluated introduce several criteria compare algorithms finally present grand challenges community consider
evaluated first implementation fls greek healthcare setting hellenic air force general hospital athens participation rate moderate needs improvement osteoporosis medication either suggested reviewed patients recruited purpose purpose study evaluate first implementation fracture liaison service fls greece hellenic air force general hospital athens methods single center prospective study may april first year second year follow conducted patients genders aged years old history low trauma fracture willing participate included identification fls nurse following recruitment osteoporosis risk factors assessed frax score calculated treatment naive patients bone mineral density bmd measured dualenergy ray absorptiometry dxa osteoporosis treatment suggested applicable rate participation indication osteoporosis treatment difficulties met evaluated results eligible patients reluctant participate personal reasons initially recruited patients mean age years discontinued participation point various reasons patients concluded study patients assessed osteoporosis risk factors given tailor made exercise education program frax score assessed treatment naive patients patients osteoporosis medication suggested reviewed patients however adherence rate available concluded study conclusions report first implementation fls greek healthcare setting participation rate moderate definitely needs improvement
relationships victimization termination pregnancy top diagnosis sexually transmitted infection sti emergency contraceptive use examined using data survey university students montreal canada female students sexually active past two years least one male partner included victimization experiences assessed logistic regressions performed predict correlates lifetime use emergency contraception top ever diagnosed sti sample reported intimate partner violence ipv reported sexual assault reported ipv factors statistically associated emergency contraceptive use top sti diagnosis older age financial hardship migratory trajectory early sexual initiation dual victimization data indicate reproductive health needs female university students experiencing victimization unmet interventions focus victimization screening enhancing reproductive autonomy
skin constantly encounters external elements including microbes culture based studies identified fungi present human skin linked species certain skin diseases moreover modern medical treatments especially immunosuppressants increased population risk cutaneous invasive fungal infections emphasizing need understand skin fungal communities health disease major hurdle studying fungal flora community level heterogeneous culture conditions required skin fungi recent advances dna sequencing technologies dramatically expanded knowledge skin microbiome culture free methods review discusses historical recent research skin fungal communities mycobiome health disease challenges associated sequencing based mycobiome research
kinin mediated angioedema results accumulation kinins vasoactive vasopermeant peptides vascular endothelium disease characterized sudden episodes swelling subcutaneous submucosal tissues edema may occur spontaneously may precipitated triggering factors physical emotional stress certain medicines characterization kinin formation catabolism systems helps improve knowledge aetiopathogenic mechanisms involved provides basis classification kinin mediated angioedema conditions thus may distinguish angioedenna inhibitor deficiency whether inherited acquired angioedema normal inhibitor activity associated increased kinin forming activity deficiency kinin catabolism enzymes support clinical diagnosis physician may request laboratory investigation functional molecular definition disease laboratory diagnosis based characterization kinin production control inhibitor investigation function antigen levels circulating species kinin production kininogenase activity kininogen cleavage species kinin catabolism enzymes aminopeptidase carboxypeptidase angiotensin converting enzyme dipeptidyl peptidase abnormal biological phenotype supported examination susceptibility genes serping xpnpep mutation segregation families elsevier masson sas rights reserved
background antidepressant drug treatments increase processing positive compared negative affective information early treatment effects hypothesized play key role development later therapeutic responses treatment however unknown whether effects common mechanism action different treatment modalities high density negative ion hdni treatment environmental manipulation efficacy randomized clinical trials seasonal affective disorder sad method current study investigated whether single session hdni treatment could reverse negative affective biases seen seasonal depression using battery emotional processing tasks double blind placebo controlled randomized study results placebo conditions participants seasonal mood disturbance showed reduced recognition happy facial expressions increased recognition memory negative personality characteristics increased vigilance masked presentation negative words dot probe task compared matched healthy controls negative ion treatment increased recognition positive compared negative facial expression improved vigilance unmasked stimuli across participants seasonal depression healthy controls negative ion treatment also improved recognition memory positive information sad group alone effects seen absence changes subjective state mood conclusions results consistent hypothesis early change emotional processing may important mechanism treatment action depression suggest effects also apparent negative ion treatment seasonal depression
shown hypoxia stimulation promotes chondrocytes autophagy partly hif alpha mir bcl progressively mechanism represented connection among hypoxia mir autophagy provides possible therapeutic strategy osteoarthritis however interaction mir bcl still unclear hypoxic environment quantified three reported mir targets two inflammation related targets traf irak reported target chondrocytes smad confirmed regulative function mir hypoxia genes explored bcl expression autophagy level extrinsic regulation three gene separately three genes regulated hypoxia surprisingly traf irak unique smad chondrocytes restored antagomir traf irak reinstated hypoxia mir repressed bcl however adsmad affect bcl hypoxia normoxia autophagy level showed reverse variability compared bcl taken together results provided evidence smad unique reported target mir chondrocytes unusually involved chondrocytes autophagy traf irak new targets mir chondrocytes autophagy
purinergic signaling maintains local tissue homeostasis blood vessels via regulation vascular tone blood platelet aggregation cell proliferation differentiation well inflammatory responses extracellular purines important signaling molecules vasculature purine hydrolysing well phosphorylating enzymes considered selectively govern extracellular nucleotide nucleoside metabolism recent studies provided evidence existence enzymes soluble form human blood secretion extracellular space physiological pathological conditions however comprehensive analysis endothelium derived enzymes involved purine metabolic pathways received attention far presented study vitro cultured human umbilical vein endothelial cells huvec shown abundant source exo nucleotidases comprising nucleotidase exo nucleoside triphosphate diphosphohydrolases exo ntpdase well phosphotransferases represented nucleoside diphosphate kinase exo ndpk adenylate kinase exo attempt also made demonstrate contrast metabolic pattern determined endothelial cell surface exo phosphorylating activities markedly predominate exo hydrolytic ones present first time expression profiles genes encoding isoenzymes belonging distinct nucleotide kinase nucleotidase families genes encoding ndpk ndpk phosphotransferases shown expressed highest level huvec cells data indicate coexistence secreted cell associated factors endothelial origin mediating atp consuming atp generating pathways predominance exo phosphotransferases activity described enzymes contribute regulation purinergic signal duration extent venous vasculature cell biochem wiley periodicals inc
three experiments examined impact excessive violence sport video games aggression related variables participants played either nonviolent simulation based sports video game baseball football matched excessively violent sports video game participants completed measures assessing aggressive cognitions experiment aggressive affect attitudes towards violence sports experiment aggressive behavior experiment playing excessively violent sports video game increased aggressive affect aggressive cognition aggressive behavior attitudes towards violence sports games competitive findings indicate violent content uniquely leads increases several aggression related variables predicted general aggression model related social cognitive models elsevier inc rights reserved
one existing problems information management information security aspects one possible solution divide information group persons authorized manage information information sharing processes allow protect information disclosure paper process division information enhanced biometric identification stage secure information processes biometric identification used manage important strategic data paper presents questions personal cryptography understood combination tasks classifying information biometric techniques used kind tasks techniques biometric data marking present examples data division sharing protocols expanded stages personal identification verification kind solutions presented tasks dividing appropriately shared secret information moreover shall present management process shadow sets parts divided secret information processes secret data management refer tasks cognitive management understood management executed basis understanding meaning processed data
background mch leadership competencies family discipline required elements leadership education neurodevelopmental related disabilities lend programs decade little research published efficacy either programmatic component development next generation leaders advocate care maternal child health mch populations objective test effectiveness integrating family discipline implementation parent led curricula trainees content knowledge skills leadership development family centered care according mch leadership competencies methods one hundred two long term lend trainees completed clinical leadership training program featured intensive parent led curricula supported full time family faculty member trainees rated five basic advanced skill items comprise mch leadership competency family centered care beginning conclusion lend traineeship results compared initial scores trainees rated significantly higher across family centered leadership competency items completion lend traineeship conclusions intentional engagement full time family faculty member parent led curricula include didactic experiential components associated greater identification adoption trainees family centered attitudes skills practices however use mch leadership competencies quantifiable measure program evaluation particularly leadership development limited
background corticosteroid treatment established first anti inflammatory treatment adults children asthma however subset patients fails respond combined systemic inhaled treatment objective study aimed understanding resistance among children severe asthma methods high resolution metabolomics performed urine samples respondent nonrespondent children determine possible urine biomarkers related resistance metabolic phenotypes responders nonresponders analyzed using bioinformatics including manhattan plot false discovery rate hierarchical cluster analysis kyoto encyclopedia genes genomes mummichog pathway analysis results way hierarchical cluster analysis study determined metabolites showing significantly different levels responders nonresponders important metabolites annotated dihydronicotinic acid methoxy hydroxyphenyl ethylene glycol dihydroxy phenylalanine gamma glutamylcysteine cys gly reduced flavin mononucleotide nacl tyrosine metabolism degradation aromatic compounds glutathione metabolism suggested significant pathways relating resistance conclusions high resolution metabolomics promising approach asthma research five candidate markers identified related resistant children severe asthma compounds upon validation may contribute understanding resistance among children severe asthma use ofurine
background toxoplasma deprives host neuron cells cholesterol leads ability potentiate dementia apoe intermediates neuronal transmission cholesterol key constituent axonal development redesigning occasions important education synaptic arrangement development memory repair neuron aim work investigate effect apoe genotypes dementia associated neurodegeneration latent toxoplasma gondii elderly population methods study comprised patients dementia positive toxoplasma igg negative subjects control group without dementia positive toxoplasma igg negative subjected cognitive assessment gondii seropositivity elisa determination apoe allelic forms pcr results apoe genotype distribution shows predominant genotype apoe widely recognized allele patients control divided toxoplasma igg positive group toxoplasma igg negative group apoe non carrier apoe apoe alleles highly significant differences dementia non dementia patients toxoplasma infected patients comparison non infected ones conclusion toxoplasma positive patients risk develop dementia regardless apoe carriage elsevier ltd rights reserved
drought induced xylem embolism serious threat plant survival future climate scenarios hence accurate quantification species specific vulnerability xylem embolism key predict impact climate change vegetation low cost hydraulic measurements embolism rate suggested prone artefacts thus requiring validation direct visualization functional status xylem conduits using nondestructive imaging techniques ray microtomography microct measured percentage loss conductance plc excised stems laurus nobilis laurel dehydrated different xylem pressures compared results direct observation gas filled water filled conduits synchrotron based microct facility using phase contrast imaging modality theoretical plc calculated basis microct observations stems laurel dehydrated different xylem pressures overall agreement hydraulic measurements revealing species suffers loss xylem hydraulic conductance xylem pressures averaging mpa data support validity estimates xylem vulnerability embolism based classical hydraulic techniques discuss possible causes discrepancies data gathered study recent independent reports laurel hydraulics
advent prosperity gps equipped devices reliable location technologies resulted wide growth location based service certain type geo spatial application moving objects fixed networks must sustain high update rate millions devices provide efficient real time querying multi attributes time period arbitrary spatial dimension traditional dbmss support complex index structures effectively cope spatio temporal data however current relational databases encountered ever increasing scale datasets make claim scalability data manage system meanwhile key value store databases designed scalable available distributed without much support data organization including management spatio temporal data paper present novel hybrid index structure organize data combining statistical based tree indexing space applying hilbert curve traversing approaching space key value store insures effective querying response time high insert rates propose rules generating target row key take skewed data handing account cluster hbase consists nodes data volume level millions implementation proves range queries queries sustain response time hundreds milliseconds
jak mutant mediated aberrant signaling pathway hallmark myeloproliferative neoplasms mpns although cytokine inducible src homology protein cis suppressors cytokine signaling socs negative regulators jak stat pathway functional role cis socs family members jak mutant induced oncogenic signaling pathway yet elucidated study found expression cis socs induced activation signal transducer activator transcription stat cells stimulated epo also cells transformed jak mutant cell proliferation tumor formation nude mice induced jak mutant significantly enhanced expression cis silenced using rna interference technique whereas knockdown socs effect enforced expression cis caused apoptotic cell death transformed jak mutant drastically inhibited jak mutant induced tumor formation cis interacted phosphorylated epor critical activation stat erk whereas activation stat erk transformed cells jak mutant increased knockdown cis enforced expression cis reduced activation molecules furthermore anti tumor effects cis required function domain tyrosine phosphorylation herein elucidated mechanism cis functions novel type tumor suppressor jak mutant induced tumorigenesis elsevier inc rights reserved
objective recent research demonstrated strong relationship psychotic experiences suicidal behaviour research date however investigated role borderline personality disorder bpd relationship despite fact bpd highly comorbid common mental disorders associated recurrent suicidal behaviour psychotic experiences paper examined relationship psychotic experiences suicide attempts including interrelationships bpd common mental disorders method used adult psychiatric morbidity study stratified multistage probability sample households england recruited nationally representative sample aged years older participants assessed common mental disorders bpd clinical subclinical suicidal behaviour psychotic experiences results approximately total sample reported psychotic experiences psychotic experiences associated increased odds suicide attempts individuals bpd individuals common mental disorder individuals without common mental disorder individuals neither common mental disorder bpd conclusion psychotic experiences associated high odds suicidal behaviour individuals without psychopathology relationship explained clinical subclinical bpd
paper includes results online survey conducted american society civil engineers asce task committee computing education assess evolution computing architecture engineering construction aec education committee aims understand measure evolution computing civil engineering architecture construction management curricula evaluate current state computing within aec curricula paper contains investigation levels concentrations computer science knowledge versus computer skills curricula addition committee seeks recognize similarities differences architecture engineering construction management programs comparing data associated disciplines paper also includes discussion basic aspects computing education including prerequisites necessary learning survey results provide useful benchmarks decision making regarding research industry collaboration curricula findings study include importance coverage computer skills competence graduates increased past decade computing skills judged important computer science knowledge aec curricula links computer science concepts aec applications computing yet fully recognized computing education sufficient meet demands aec industry share computing courses less educators desire scientific concepts computing important preparing architects engineers unknown future developments information technology american society civil engineers
reversible logic gained importance field low power digital design digital system comparator plays important role determining whether two referenced numbers either equal greater lesser work deals optimization existing reversible comparator designs also proposes new multiplexer based logic design reversible comparator along design methodology bit comparators proposed design optimized multiple performance parameters compared existing state art designs proposed multiplexer based design improvement quantum cost garbage outputs ancilla inputs optimized designs find application predominantly field quantum computing low power signal processing parallel computing memories digital system design multi processing
lately important advances take place dermatological treatment phototherapy one oldest treatment modalities history dermatology fall behind advances contrary still used widely treatment many skin diseases advantages effective safe article aims give practical basic information artificial ultraviolet sources dosimetry calibration standards sources ultraviolet treatment protocols starting history current phototherapy modalities
psychiatric disorders anxiety depression addiction often comorbid brain pathologies thought share common mechanistic biology part cortico limbic circuit nucleus accumbens shell nacsh plays fundamental role integrating information circuit modulation nacsh circuitry alters anxiety depression addiction related behaviors intracellular kinase cascades nacsh proven important mediators behavior investigate glycogensynthase kinase gsk beta signaling nacsh vivo knocked gskbeta expression novel adeno associated viral vector aav assessed changes anxiety depression like behavior cocaine self administration gskbeta knockdown rats gskbeta knockdown reduced anxiety like behavior increasing depression like behavior cocaine self administration correlative electrophysiological recordings acute brain slices used assess effect aav shgskbeta spontaneous firing intrinsic excitability tonically active interneurons tans cells required input output signal integration nacsh processing reward related behaviors loose patch recordings showed tans transduced aav shgskbeta exhibited reduction tonic firing increased spike half width assessed whole cell patch clamp recordings changes mirrored reduction action potential firing accompanied decreased hyperpolarization induced depolarizing sag potentials increased action potential current threshold decreased maximum rise time results suggest silencing gskbeta nacsh increasesdepression addiction related behavior possibly decreasing intrinsic excitability tans however study rule contributions neuronal sub types elsevier ltd rights reserved
gap junctions underlie electrical synaptic transmission neurons generally perceived simple intercellular channels electrical synapses demonstrated functionally sophisticated structurally complex initially anticipated electrical synapses represent assembly multiple molecules consisting channels adhesion complexes scaffolds regulatory machinery trafficking proteins required proper function plasticity additionally electrical synapses often viewed strictly symmetric structures emerging evidence shown components forming electrical synapses differentially distributed side junction propose molecular complexity asymmetric distribution proteins electrical synapse provides rich potential functional diversity wiley periodicals inc
paper presents damage evaluation method estimates damage level buildings using ambient vibration measurement seismic interferometry technique new index named slowness change directly relates reduction story stiffness vibration signal travel time delays propagating waves introduced sensitivity slowness change damage examined ambient vibration testing quarter scale steel frame damage simulated removing steel links member ends slowness changes computed measurement data increased significantly number fractures increased story stiffness decreased results showed strong relationship location amount simulated fractures slowness change paper also discusses signal processing measurement parameters required accurately identify parameters propagating waves error associated signal processing measurement borderline detectable undetectable damage beam fractures column fractures steel frames american society civil engineers
distinctive encoding greatly influenced gist based processes shown suffer highly similar items presented close succession thus elucidating mechanisms underlying presentation format affects gist processing essential determining factors influence encoding processes current study utilised multivariate partial least squares pls analysis identify encoding networks directly associated retrieval performance blocked intermixed presentation condition subsequent memory analysis successfully encoded items indicated significant differences reaction time retrieval performance presentation format despite significant behavioural differences behaviour pls revealed differences brain behaviour correlations mean condition activity brain regions associated gist based distinctive encoding specifically intermixed format encouraged distinctive encoding showing increased activation regions associated strategy use visual processing frontal visual cortices respectively alternatively blocked format exhibited increased gist based processes accompanied increased activity right inferior frontal gyrus together results suggest sequence information presented encoding affects degree distinctive encoding engaged findings extend understanding fuzzy trace theory role presentation format encoding processes
exposures particulate matter diameter less may influence risk birth defects make allergic causes serious harm human health bamboo charcoal adsorb harmful substances benefitto people health order figure optimal adsorbtion condition intrinsic change bamboo charcoal five chemicals adsorbed bamboo charcoal analyzed optimal blast time min naso min naso min naso min min min spectra showed bamboo charcoal five characteristic peaks sas stretch stretch stretch stretch stretch stretch respectively naso peaks achieved maximum min naso peaks achieved maximum min naso peaks achieved maximum min peaks achieved maximum min peaks achieved maximum min peaks achieved maximum min proved bamboo charcoal could remove sulfur powder air restrain sulfur allergies authors production hosting elsevier behalf king saud university
one first steps innovation projects entrepreneurial initiative involves formulating business model describes value creation delivery capturing logic business idea however formulating networked enterprises alignment collective supporting joint service product offer underlying operational processes networked businesses need taken account paper analyses concept business model alignment bma based qualitative case studies two smart living projects finland china begin business model framework stof applied describe high level next value information process vip framework applied analyse bma case studies show analytical framework vip model helps reveal hurdles may undermine bma result obstruct implementation paper contributes existing literature identifying steps necessary move abstract often strategy driven collaborating enterprises towards aligned implemented paper also contributes theory formation identifying issues play role achieving bma
generally speaking confucian study philosophy sphere concerns thoughts notions nowadays often neglects empirical foundations notions however bias modern sight prejudice probably lead kind reductionism example see sacred feelings confucians levels result reduce sacred dimension confucian tradition another kind merely morality sense necessary explore confucian historical experiences viewpoint religious study play important role understand confucian spirituality methodological reflection made article study confucian ritual experience viewpoint religious study example chu hsi experiences sacrificing confucius approach personal life experience confucian history highlighted
progress understanding disease processes provided additional therapeutic targets best exemplified increasing role biologics clinical armamentarium article provides focused review current treatment paradigms pathophysiology asthma atopic dermatitis urticaria well inhibitor deficiency elucidates populations biologics studied aforementioned disease states emphasizing characteristics consider selecting therapy important correctly estimate patient outcome starting therapy based cost analysis treatment decisions need guided appropriate patient stratification based individual underlying phenotype
structural deterioration damage civil infrastructures may results severe losses properties human lives prevent situations structure health monitoring shm technologies developed recent decades one shm technologies called system identification methods aim estimate structural parameters minimizing error function consisting measured calculated responses structure loading condition optimization based algorithms may suffer ill posedness inverse problem may result non uniqueness solutions non stability optimization process paper order avoid issues related ill posedness method based bayesian network technology developed especially probabilistic identification spatial distribution structural parameters utilizing graph theories describes random variables nodes connected links represent conditional probability tables cpt explaining probabilistic relationship linked nodes effective using study proposes graph model employs variate gaussian function shape function describing spatial distribution structural parameter small number parameters parameters gaussian shape function considered nodes describe various spatial distribution patterns using small number parent nodes using modeling approach number nodes affected size finite element mesh thus approach prevents graph growing intractable size even analysis requires smaller meshes improve accuracy structural analysis using constructed information applied loads observed structural responses inference algorithm effectively updates prior distribution spatial distribution parameters posterior distribution proposed method tested demonstrated numerical examples using variety structural deterioration scenarios results proposed method compared maximum likelihood estimation mle updating method test influences measurement errors incomplete missing data performance methods also investigated results show proposed approach stable robust tested methods potentially merits worth investigating future research elsevier ltd rights reserved
background cigarette smoking one common addictions worldwide muslim smokers reduce number cigarettes smoke ramadan due long fasting hours objectives aimed share experience smoking cessation clinic ramadan analyzing efficacy adverse effects daily dosing bupropion varenicline fasting group compared conventional dosing non fasting group methods analyzed patients attended smoking cessation clinic ramadan least one follow visit fasting patients prescribed bupropion varenicline dinner daily maintenance therapy recorded demographic characteristics patients fasting state drugs taken smoking cessation dosage medication first follow visit adverse effects seen treatment recorded conducted telephone interviews months first visits patients learn current smoking status groups results total patients fasting fasting fasting non fasting patients similar sex age smoking pack years marital status educational status mean fagerstrom scores adverse effects quit rates months follow similar fasting non fasting groups conclusion although sample size small found difference rates adverse effects smoking cessation using single daily oral dose bupropion varenicline fasting group non fasting group received conventional dosing
mental well world adolescents decreased last years trend visible also sweden country otherwise considered positive example terms child well sweden students lower secondary school especially exposed salutogenic orientation study qualitatively explored swedish students grades perceptions role happiness school students perceived happiness promoting promoted five aspects learning school engagement appreciation subjects lesson content others happiness prosocial behavior hence five perceived bidirectional crossovers subjective well found compared findings previous research determinants effects happiness students perceptions add new direction future research align several respects decades earlier research
compared prime lenses zoom lenses inherent advantages terms operational flexibility zoom lens camera systems therefore extensively adopted computer vision precise measurement primary objective however variation intrinsic camera parameters respect zoom lens settings poses series calibration challenges inhibited widespread use close range photogrammetry flexible zoom lens calibration methodology therefore proposed study developed aim simplifying calibration process promoting practical photogrammetric application zoom dependent camera model incorporates empirical zoom related intrinsic parameters collinearity condition equations developed coefficients intrinsic parameters solved single adjustment based zoom lens camera model validate approach experiments optical digital zoom lens cameras conducted using planar board evenly distributed circular targets zoom lens calibration performed images taken four different zoom settings spread throughout zoom range lens photogrammetric accuracies achieved mono focal multi focal triangulations evaluated calibration relative accuracies mono focal triangulations ranged two cameras studied whereas multi focal triangulation accuracies ranged order demonstrate applicability approach calibrated zoom lens imagery used render laser scanned point cloud building facade considered alongside experimental results successful application demonstrates feasibility proposed calibration method thereby facilitating adoption zoom lens cameras close range photogrammetry wide range scientific practical applications
three dimensional zno fes materials synthesized top graphene layer using facile cost effective hydrothermal growth method graphene zno demonstrated efficient alternative standard fluorine doped tin oxide fto zno based photoanode dye sensitized solar cells dsscs due larger surface area better charge transport characteristic higher electrochemical activity addition graphene fes nanostructures also revealed efficient replacement conventional counter electrode exploiting synergy components dsscs power conversion efficiency pce demonstrated simulated solar radiation elsevier rights reserved
links media violence exposure favorable attitudes toward interpersonal violence well established studies examined whether associations extend include favorable attitudes toward institutional forms aggression studies topic assessed multiple forms media use statistically controlled individual characteristics likely influence attitudes beyond sociodemographic information study undergraduate students aged years male completed survey assessing media use number hours per week spent playing videogames watching movies shows watching sports attitudes toward interpersonal violence punitive criminal justice policies different types military activities preparedness defense aggressive intervention greater number hours spent watching contact sports associated favorable attitudes toward military preparedness defense aggressive military intervention punitive criminal justice policies among men independently parental education lifetime violence exposure within home community aggressive personality constrained problem solving style greater number hours spent watching violent movies associated favorable attitudes toward military preparedness defense among men favorable attitudes toward interpersonal violence punitive criminal justice policies among women associations became nonsignificant adjusting covariates
simple synthetic wavelength self mixing interferometer proposed precision displacement measurement choosing frequency difference orthogonally polarized dual frequency laser appropriately introduce synthetic wavelength theory self mixing interference principle demonstrate feasible optical configuration simply adjusting optical design self mixing interferometer phase difference two orthogonally polarized feedback fringes observed tiny displacement object measured phase change synthetic signal since virtual synthetic wavelength times larger operating wavelength sub nanometer displacement object obtained millimeter criterion measurement without modulation demodulation complicated electrical circuits experimental results verifies synthetic wavelength self mixing interferometer ability measuring nanoscale displacement provides potential approach contactless precision displacement measurement number scientific industrial applications elsevier rights reserved
paper novel high frequency fully differential pure current mode current operational amplifier coa proposed authors knowledge first pure mosfet current mode logic mcml coa world far fully current mode signal processing avoiding high impedance nodes signal path grant proposed coa outstanding properties high current gain broad bandwidth low voltage low power consumption principle operation block discussed outstanding properties verified hspice simulations using tsmc cmos technology parameters pre layout post layout plus monte carlo simulations performed supply voltages investigate robust performance presence fabrication non idealities pre layout plus monte carlo results current gain phase margin cmrr input impedance output impedance consumed power also post layout plus monte carlo simulation results generally believed reliable practical measuring ones extracted favorably show abovementioned order pre layout current gain phase margin cmrr input impedance output impedance consumed power results altogether prove excellent quality well resistance proposed coa technology fabrication non idealities
paper examines effect divorce law reforms fertility using history legislation divorce across europe introduction liberal divorce laws permanently reduces value marriage relative divorce permanent shocks also affect fertility decisions individuals extent children considered marriage specific capital results suggest divorce liberalization negative permanent effect fertility divorce reforms decreased total fertility rate magnitude effect sizable taking account average total fertility rate declined findings robust alternative specifications controls observed liberalization abortion availability birth control pill among others unobserved country specific factors well time varying factors country level supplemental analysis developed understand mechanisms divorce law reforms affect fertility shows marital wedlock fertility decline impact marital fertility varies depending whether couples married prior divorce law reforms pointing selection effect composition marriages elsevier rights reserved
despite popularity cause related marketing crm socially oriented drivers influence success crm yet investigated empirically hospitality context study investigated effects three factors status motive guilt recognition customers attitudes intent participate crm promotions social media scenario based subjects experimental design used results revealed status seeking individuals exhibited high level prosocial behavior behavior recognized others publicly compared non status seeking individuals addition individuals felt guilt regards crm promotional appeal likely respond promotion positively goodwill observable others considering desire customers goodwill displayed others known conspicuous prosocial behavior study provides important evidence companies wishing develop crm strategies via social media elsevier ltd rights reserved
aim chemotherapeutic regimens chr digitalization project proposal universal structure creation publicly accessible database contemporary chr universal utility communication evaluation contemporary newly defined clinical schedules anti tumor chemotherapy analysis contemporary anti tumor chr standard xml structure proposed enables recording simple chr field chemotherapy solid adult tumors also potential recording complex treatment protocols field paediatric oncology resulting xml documents saved web server publicly accessible chr database constructed total xml documents definitions individual chr first phase linked data store three examples web applications added demonstrate potential uses newly created database
explore mechanism bushen qiangji granule eyene cent bsqj restraining osteogenic differentiation ankylosing spondylitis fifibroblasts hip joint capsules obtained patients receiving total hip replacement healthy hip joint capsules patients hip fracture receiving surgery control finite fifibroblast lines established tissue samples observe effect bsqj suppressing osteogenic differentiation fifibroblasts expression osteogenic marker gene corebinding factor cbfa smad family proteins examined western blot real time quantitative polymerase chain reaction qpcr mrna expression level cbfa significantly higher fibroblasts normal fibroblasts expression psmad psmad smad cbfa fibroblasts also higher demonstrating activation bmp smads signal pathway fifibroblasts bsqj medicated serum restrained mrna protein expression levels cbfa inhibited protein expression level smad also decreased expression quantities psmad psmad bsqj inhibit osteogenic differentiation fifibroblasts vitro suppressing activation bmp smads signal pathway may important molecular mechanism bsqj regulating ossifification
time dependent thermodynamics applied steady state melt flow polyethylene steady state viscosity behavior first normal stress difference examined couple latter measure energy intensity energy per volume time derivative treated rate energy production steady state flow viscosity decreased rate energy production increased increasing shear stress sign rate production steady flow found stable region stress growth leading steady state flow known previous work unstable region may called pseudo stable region constant rate shear deformation shear stress viscosity increased rapidly change steady state flow interpreted fracture point growth normal stress slower shear stress first normal stress difference manifestation deformation volume increase caused shear stress volume increase led fracture
hominin evolution characterized two main trends transition bipedality increase brain size fossil evidence shows trends major impact structure function hominin skull chapter asks evolutionary modification cranial ontogenetic program led morphological reorganization hominin skull ultimately hominin cranial diversity three major mechanisms evolutionary developmental reorganization proposed modified prenatal development cranial base face reflects adaptation bipedality high rates neurocranial growth early postnatal ontogeny essential attain large brain sizes taxon specific modification facial development reflects dietary adaptation genus homo general trend toward neoteny
multi population method widely used solve unconstrained continuous dynamic optimization problems aim maintaining multiple populations different peaks locate track multiple changing peaks simultaneously however make approach efficient several crucial challenging issues need addressed determine moment react changes adapt number populations changing environments determine search area population addition several issues communication populations overlapping search way create populations detection changes local search operators also addressed lack attention challenging issues within multi population methods hinders development multi population based algorithms dynamic environments paper challenging issues comprehensively analyzed set experimental studies algorithm design point view experimental studies based set popular algorithms show performance algorithms significantly affected challenging issues moving peaks benchmark elsevier inc rights reserved
background hereditary angioedema inhibitor deficiency inh hae characterized recurrent attacks swelling affect various body sites attacks frequent cause visits emergency department often treated hospital recent years self administration inhibitor inh concentrates home become increasingly used option positive impact patient outcomes quality life methods observational study months duration patients inh hae referred hae center southern italy patients received three types treatment swelling attacks inh concentrates administered home icatibant administered home inh concentrates administered hospital objectives observational study compare therapy compliance defined proportion treated attacks quality life home hospital treated patients identify factors associated decision use home therapy results overall attacks reported months treated total number reported attacks mean number attacks per patient respectively three groups home based inh home based icatibant hospital based inh differences attack frequency home hospital based treatments statistically significant patient demographic characteristics disease severity score correlate use home therapy compliance therapy significantly better home based therapy treated attacks inh icatibant hospital based therapy quality life showed opposite trend patients hospital based treatment reporting highest quality life conclusions home based therapy associated better compliance compared hospital based therapy choice adopt home based therapy appeared correlate high attack frequency home based therapy valid treatment option patients inh hae offered patients especially high attack frequency
recently wireless charging via magnetic resonance coupling gained attention potential efficient midrange wireless charging functions sensing transmitter wireless communication target essential elements realize standard wireless charging system currently sensing communication protocol hardware high frequency power source antenna configuration compatible wireless charging gaining attention terms cost space reduction due use common components multiple functions however protocol problem narrow effective areas due fact sensing range depends fixed factor antenna overcome problem concept wide area sensing based controllable antenna proposed effectiveness verified theoretical analysis experiment result clarified effective area expanded ratio distance transmitting receiving antennas inner diameter antenna wiley periodicals inc
due increased size complexity power system network stability load frequency control lfc serious concern wide area monitoring system wams obtained signals phasor measurement unit pmu quality services qos communication infrastructure terms signal delay packet loss probability queue length throughput important must considered carefully wams based thermal power system however studies presented includes qos communication infrastructure load frequency control lfc power system paper presents lfc two area thermal power system based estimated time delay packet loss probability using markovian approach delay packet loss probability modeled different math functions normally frequency deviation signal transmitted remote terminal unit rtu control center control center individual control unit plants delay incurred located forward loop pso based pid controller form transport delay verify efficacy controller performance estimated constant delay time varying delay applied controller two area thermal thermal power system without governor dead band gdb generation rate constraints grc various loads conditions study demonstrated time delay compensated order pade approximation results show frequency deviation minimum terms stability transient response elsevier rights reserved
treatment response follicular lymphomas highly variable therefore investigated role cancer associated fibroblasts cafs tumor cell viability particular response treatment cytotoxic drugs stromal cells outgrown patients characterized pure caf populations cultivated cells analyze fibroblast mediated effects cells culture treated abt bortezomib adherent cell population positive fibroblastic markers tested showed increased mrna expression activation marker fap effect cell viability noted cultivating cafs however stromal cells protected tumor cells apoptosis response cytotoxic treatment might explained mrna induction abcc abcg regulation bcll cells finding protective mechanisms mediated cafs pivotal impact studies cytotoxic agents
although animal research demonstrated seasonal changes hippocampal volume reflecting seasonal neuroplasticity seasonal differences human hippocampal volume yet documented hippocampal volume also linked depressed mood seasonally varying phenotype therefore hypothesized seasonal differences day length photoperiod would predict differences hippocampal volume association would linked low mood healthy participants aged university pittsburgh adult health behavior project female scanned mri scanner hippocampal volumes determined using automated segmentation algorithm using freesurfer mediation model tested whether hippocampal volume mediated relationship photoperiod mood secondary analyses included seasonally fluctuating variables sleep physical activity shown influence hippocampal volume shorter photoperiods significantly associated higher bdi scores smaller hippocampal volumes however due lack association hippocampal volume beck depression inventory scores current sample mediation hypothesis supported study first demonstrate association season hippocampal volume data offer preliminary evidence human hippocampal plasticity could associated photoperiod indicates need longitudinal studies wiley periodicals inc
chapter deals methods predicting strength overlap composite joints marine applications ships offshore structures failure loads obtained experimentally presented compared theoretical predictions capacity estimates provided traditional strength materials approaches agree experiments results obtained using recently developed inelastic fracture based analysis method represent measured strength values well
rock detention structures used restoration treatments engineer ephemeral stream channels southeast arizona usa reduce streamflow velocity limit erosion retain sediment promote surface water infiltration structures intended aggrade incised stream channels yet little quantified evidence efficacy available goal year study characterize geomorphic impacts rock detention structures used restoration strategy develop methodology predict associated changes studied reaches two ephemeral streams different watershed management histories one thousands loose rock check dams installed years prior study one structures constructed beginning study methods used included runoff sediment transport geomorphic modelling repeat terrestrial laser scanner tls surveys map landscape change discharge data available event based runoff estimated using kineros one dimensional kinematic wave runoff erosion model discharge measurements estimates used input two dimensional unsteady flow sedimentation model naysdh combined gridded flow transport bed bank simulation geomorphic change comparison consecutive dems potential substitute uncalibrated models analyze stream restoration introduced demonstrate new approach assess hydraulics associated patterns aggradation degradation resulting construction check dams transverse structures notably find stream restoration using rock detention structures effective across vastly different timescales published elsevier
colonoscopy exam images useful identify diseases colorectal cancer one common cancers worldwide computational image analysis machine learning techniques assist experts identify abnormalities images work present evaluate mias aims help experts study analyze colon tissue images system initially extracts features images currently amadasum haralick laws texture descriptors supported described images classified normal abnormal images version nearest neighbor backpropagation based multilayer perceptron naive bayes support vector machine classification algorithms implemented mias developed open source technologies using software engineering approach improve flexibility maintainability work mias quantitatively assessed application set tissue image fragments classifiers built set compared according cross validation contingency table strategies also system qualitatively evaluated using heuristics twelve volunteers health exact sciences issues found categorized according rolf molich severity scale result classifier achieved highest sensitivity reasonable average error qualitative evaluation issues found considered serious assessments suggest mias useful assist domain experts minimum knowledge informatics conduct complete studies medical images identifying patterns regarding different abnormalities published elsevier ltd
objectives adverse childhood experiences aces consistently linked strong graded fashion host health problems later adulthood studies examined proximate effect aces health emotional well adolescence study design nationally representative cross sectional study methods using logistic regression national survey children health examined cumulative effect total ace score health emotional well adolescents aged years investigated moderating effect family functioning impact ace adolescent health emotional well results adolescents higher ace scores worse reported physical emotional well adolescents fewer aces net key demographic socio economic characteristics family functioning moderated negative impact cumulative ace adolescent health emotional well conclusions adolescent well enduring consequences identifying children ace exposure also lower functioning family could also help identify families particular risk royal society public health published elsevier ltd rights reserved
ordinary differential equations polynomial dependent variable derivatives two methods provided find possible reductions first order ordinary differential equations computer codes underlying algorithms also given techniques applied find new explicit solutions relevant equations mathematical physics elsevier rights reserved
purpose purpose study gather baseline data health promoting lifestyle practices rns working six major health care educational institutions southeast pennsylvania community methods descriptive correlational study design used item health promoting lifestyle profile instrument used explore participants self reported health promoting behaviors measure dimensions health responsibility physical activity nutrition interpersonal relations spiritual growth stress management results findings revealed physical activity stress management scores low entire group rns statistically significant differences nurses years age older years age subscales health responsibility nutrition stress management suggesting older nurses concerned health also statistically significant differences nurses years age older years age younger subscale health responsibility sixty seven percent participants reported many competing priorities significantly lower subscale scores spiritual growth interpersonal relations stress management well significantly lower total scores conclusion study findings provided baseline data useful planning health promoting lifestyle interventions participants specific institutions may help guide future research educational initiatives related numerous issues common workforce failure many nurses take adequate care needs better understood addressed individual nurses employers
objective medullary streaks detected fluid attenuated inversion recovery flair imaging considered reflected ischemic regions pediatric moyamoya disease purpose study evaluate medullary streaks clinically radiologically discuss associated pathophysiological concerns methods authors retrospectively reviewed data consecutive pediatric patients moyamoya disease treated april june clinical radiological features postoperative imaging changes analyzed patients hyperintense medullary streaks flair imaging hmsf level centrum semiovale detected results hmsf coincident hyperintense medullary streaks weighted image though completely coincident vasculature either weighted image contrast enhanced analysis revealed significantly higher values terms angiography scores number flow voids basal ganglia presence medullary artery group hmsf without contrast presence white matter damage significantly less frequent hmsf group hmsf disappeared surgery mean apparent diffusion coefficient level significantly reduced postoperatively conclusions although hmsf associated collateral circulation moyamoya disease factors may involved including stagnated cerebrospinal fluid vasogenic edema relevant impaired state white matter findings study provide insight pathophysiological basis perivascular space moyamoya disease
suicidal behavior regarded act person seeks take life aware consequences action review besides describing main introductory aspects concept suicide focus attention main neurophysiological genetical mechanisms relevant extremely difficult manage controversial behavior moreover considering latest interests current literature relevance central oxytocin various superior cognitive behaviors also make short description important effects oxytocin could context suicidal behavior
retinoic acid inducible gene rig functions one major sensors rna viruses ddx encodes rig protein newly identified susceptibility gene psoriasis show activation rig ppp dsrna synthetic ligand directly causes production triggers psoriasis like skin disease mice repeated injections ears failed induce production full psoriasis like skin phenotype either germ free rig deficient mice rig also critical full development skin inflammation imiquimod imq induced psoriasis like mouse model furthermore rig mediated endogenous production mainly confined cdc dendritic cells dcs via nuclear factor kappa kappa signaling stimulated rig expression auto regulatory feedback loop thus data suggest dysregulation antiviral immune responses hosts innate pattern recognition receptors may trigger skin inflammatory conditions pathophysiology psoriasis
although well established hiv related stigma depression lack social support negatively associated health related quality life hrqol among people living hiv plh studies date examined psychosocial factors interact affect hrqol among incarcerated plh therefore incorporated moderated mediation model mmm explore whether depression mediates effect hiv related stigma hrqol function underlying level social support incarcerated hiv infected men opioid dependence recruited hiv units kajang prison malaysia participants completed surveys assessing demographic characteristics hiv related stigma depression social support hrqol results showed effect hiv related stigma hrqol mediated via depression beta beta demonstrated two tailed significance test sobel furthermore association social support hrqol positive beta whereas interaction hiv related stigma depression negatively associated hrqol beta indicated predicted influence hiv related stigma hrqol via depression negative effect hrqol individuals low social support results suggest social support buffer negative impact depression hrqol highlights need future interventions target psychosocial factors order improve hrqol among incarcerated plh
backgroundfew epidemiologic studies examined full range adolescent psychiatric disorders general population association psychiatric symptom clusters pscs dsm alcohol use disorders auds among adolescents well understood methodsthis study draws upon public use data national household survey drug abuse including study sample respondents aged logistic regression exploratory structural equation modeling assess associations pscs dsm auds gender pscs based brief screening scales devised diagnostic interview schedule children predictive scales resultsseveral pscs found significantly associated dsm auds including separation anxiety generalized anxiety depression oppositional defiant disorder conduct disorder among genders panic disorder obsessive compulsive disorder among females consistent literature analysis pscs yields factors identical genders internalizing factors fear anxiety misery externalizing factor adolescents scored higher externalizing factor tended higher levels aud factor female adolescents scored higher internalizing misery factor lower internalizing fear factor also tended higher levels aud factor conclusionsthe associations found pscs auds among adolescents study consistent found among adults studies although gender may moderate associations internalizing pscs auds findings lend support previous findings developmentally stable associations disruptive behaviors auds among adolescents well adults general population
cells recognize antigen using large diverse set antigen specific receptors created complex process imprecise somatic cell gene rearrangements response antigen receptor binding specific cells divide form memory effector populations apply high throughput sequencing investigate global changes cell receptor sequences following immunization ovalbumin ova adjuvant understand adaptive immunity achieves specificity immunized mouse contained predominantly private related set expanded cdr beta sequences used machine learning identify common patterns distinguished repertoires mice immunized adjuvant without ova cdr beta sequences deconstructed sets overlapping contiguous amino acid triplets frequencies motifs used train linear programming boosting lpboost algorithm lpboost classify tcr repertoires lpboost could distinguish two classes repertoire accuracies using small subset triplet sequences present defined positions along cdr results suggest model motifs confer degenerate antigen specificity context highly diverse largely private set cell receptors
present paper establishes homotopy based marcus wyse brevity topology contribute classification digital images topological approach since topology considered euclidean space integer coordinates used studying digital images viewpoints digital topology digital geometry image processing image analysis computer graphics mathematical morphology forth develop homotopy present paper uses two maps continuous map marcus wyse adjacency brevity map features merits besides using homotopy present paper proposes homotopy equivalence contractibility also used classifying digital images finally paper establishes homotopic thinning derived homotopy contribute compression digital images elsevier rights reserved
aimsto present methodological exemplar integrating findings quantitative qualitative review topic provide insight components care contribute supportive care acceptable men prostate cancer backgroundmen prostate cancer likely live long time disease experience side effects treatment therefore ongoing supportive care needs quantitative qualitative reviews published findings yet integrated designintegration quantitative qualitative synthesized evidence data sourcetwo previously published systematic reviews review methodssynthesized evidence supportive care men prostate cancer integrated two previously published systematic reviews narrative quantitative review qualitative review thematic synthesis two streams synthesized evidence synthesized using concurrent narrative summary data reviews used develop set propositions summary components care likely contribute supportive care acceptable men prostate cancer identified resultsnine propositions developed covered men supportive care focusing role health professionals propositions used compose nine components care likely lead supportive care acceptable men prostate cancer components low cost developing empathic personalized approach specific approaches need investigation randomized controlled trials example online support conclusionthis methodological exemplar demonstrates integration quantitative qualitative synthesized data determine components care likely lead provision supportive care acceptable men prostate cancer
integration multibarrel glass capillaries microfluidic flow configuration demonstrated parallel production nanoliter scale droplets multibarrel system supports generation continuous stream single phase dual phase droplets digital control droplet content enabling formation dynamically programmable tunable emulsions multibarrel capillary method allows simultaneous generation multiple droplets parallel droplet generators controlled switching selected dispersed phase continuous phase compositions individual phases emerging capillary outlet may selected yield merged droplets combining continuous phase emitted one neighboring droplet generators capillary emitters configured two dimensional array multibarrel system provides greater flexibility toward producing controlled interactions multiple solutions phases conventional planar microfluidic droplet generators using barrel capillary configuration ability regulate droplet composition particle size individual well combined single merged water oil droplets explored together use two dimensional spatial control within multibarrel array generate higher order emulsions elsevier rights reserved
report young adult female presenting altered mental status chest pain timely review electronic medical record revealed history panhypopituitarism poor medication adherence although unknown time initial evaluation patient required hormone replacement significant fluid resuscitation followed definitive treatment pericardiocentesis discharged home hospital day normalization diminished left ventricular ejection fraction month follow although panhypopituitarism cardiac tamponade rare diagnoses highlight management severe hypothyroidism importance early administration hydrocortisone panhypopituitarism need aggressive volume expansion maintain preload cardiac tamponade
self interested moves manipulation deception interpersonal relationships parties inside outside workplace constitute serious concern management machiavellianism often directly blamed ethical failures generic individual differences linked use chameleon like approaches match immediate cultural social environment external locus control relativistic beliefs may indirect influences chameleon inducing personalities may foster self interested decisions prompting abandonment strict moral codes study investigates machiavellianism potential mechanism personalities relate negatively ethical work intentions results obtained sample banking employees spain reveal external locus control relativistic beliefs relate positively machiavellianism machiavellianism mediates negative influence chameleon inducing personalities ethical work intentions study thus provides novel information managers interested reducing employees machiavellian tendencies offers appropriate strategies deterring unethical work behaviors elsevier ltd rights reserved
purpose develop validate fast sensitive simple liquid chromatographic method coupled tandem mass spectrometry determination potent tyrosine kinase inhibitor ninetedanib ntb plasma utilizing cyclobenzaprine cbp internal standard methods separation two components ntb cbp performed pentafluorophenyl pfp reversed phase column ambient temperature using isocratic elution acetonitrile water containing ammonium formate buffer flow rate min ntb cbp monitored triple quadrupole tandem mass spectrometer electrospray ionization source positive ion mode current method validated following european medicines agency ema guidelines results proposed method allowed rapid specific quantification ntb calibration range determination coefficient intra inter day accuracy precision cases conclusion developed procedure rapid specific reliable validated quantification ntb human plasma thus applied efficiently analysis clinical samples containing ntb
overactive bladder oab symptom driven condition characterized urinary urgency without urinary incontinence common problem significantly affect quality life drugs prevent acetylcholine mediated involuntary detrusor contractions mainstay oab treatment several alternative therapeutic options become established treatments oab mirabegron beta adrenoceptor agonist different mechanism action antimuscarinic agents recently published randomized controlled trials shown mirabegron effective safe drug symptomatic treatment oab patients mirabegron represents valid option patients oab antimuscarinics treatment naive well unresponsive intolerant antimuscarinics intravesical injection botulinum toxin effective treatment oab refractory antimuscarinics treatment botulinum toxin showed clinically relevant improvement oab symptoms health related quality life generally well tolerated patients treatment related complications acceptable however increased risk larger volume post void residual urine noted several patients possibility chronic catheterization requires careful evaluation treatment sum recent options management oab mirabegron intravesical injection botulinum toxin expand treatment options optimal treatment patient
young adults autism spectrum disorder asd experience significant rates unemployment underemployment field needs inexpensive evidence based vocational intervention examined approach developed people serious mental illness ips supported employment young adults asd described pilot ips program young adults asd evaluated first five participants year first five ips participants succeeded competitive employment expanded independence achieved broad psychosocial gains ips could help young adults asd succeed competitive employment relatively low cost
present results analyzing physical morphological properties dimmings transient coronal holes associated flares coronal mass ejections cmes dimming catalog processed semi automated coronal dimming tracker using solar dynamics observatory aia angstrom observations hmi magnetograms instead typically used difference images used coronal hole detection algorithm detect transient dark regions directly extreme ultraviolet euv images allowed study dimmings footpoints cmes contrast larger diffuse dimmings seen difference images represent projected view rising expanding plasma studying footpoint dimming morphology allowed better understand cme structure low corona comparing physical properties dimmings flares cmes also able identify relationships different parts complex eruptive phenomenon found larger dimmings longer lived suggesting takes longer close large open magnetic regions also growth phase smaller dimmings acquire higher magnetic flux imbalance become unipolar larger dimmings furthermore found euv intensity dimmings indicative local electron density correlates much plasma removed energetic eruption studying morphology dimmings single double fragmented also helped identify different configurations quasi open magnetic field
testosterone replacement therapy trt emerged commonly prescribed therapy symptomatic low testosterone conflicting data reported terms efficacy potential adverse outcomes one controversial associations trt cardiovascular morbidity mortality review briefly provides background history trt indications trt data behind trt symptomatic low testosterone specifically delves rather limited data cardiovascular outcomes low endogenous testosterone receive trt available body literature strongly suggests work way clinical trials needs done better understand impact testosterone trt cardiovascular system
past decades dramatic shift understanding personality disorders borderline personality disorder bpd historically viewed entrenched pattern antagonistic interpersonally dependent uncorrectable conduct seen outcome complex yet modifiable developmental processes borderline label inspired harsh opprobrium clinical communities early diagnosis considered taboo increasingly applied adolescents receiving effective treatment desisting borderline trajectory research examining developmental origins early manifestations bpd increasing rapidly making appropriate time take stock current developmental research articulate agenda future identify challenges continue impede innovative research borderline personality development inadequate attention continuity discontinuity across development medical diagnostic systems localize personality pathology within individual lingering belief biological research antithetical contextual interpersonal understandings psychopathology vice versa reluctance reach across disciplinary developmental boundaries identify creative paradigms foster innovative discovery order overcome challenges propose approach future research adolescent borderline pathology integrates developmental psychopathology social affective neuroscience personality theory perspectives intersection developmental neuroscience personality pathology offers theoretical methodological advantages disciplinary isolation fertile ground generating novel hypotheses development prevention bpd
subcutaneous rupture peroneus longus tendon occurring fracture peroneum secondary posterior dislocation uncommon sesamoid bone rare authors report three incidents injury presented either fracture diastasis fragments posterior dislocation whole without fracture cases conservative treatment yielded satisfactory results emphasized cases ankle injury radiologists carefully examine plain radiographs injuries seen images obtained time injury discovered retrospectively fragments separate treating problem early stage may lead instability ankle peroneal compartment syndrome
background little known smoking cessation practices primary care differ patients coronary heart disease chd different comorbidities aim determine association different patterns comorbidity smoking rates smoking cessation interventions primary care patients chd design setting cross sectional study adults chd primary care scotland method details eight concordant physical comorbidities discordant physical comorbidities eight mental health comorbidities extracted electronic health records april march multilevel binary logistic regression models constructed determine association patterns comorbidity smoking status smoking cessation advice smoking cessation medication nicotine replacement therapy prescribed results deprived quintile nearly three times higher odds current smokers least deprived odds ratio confidence interval people chd two mental health comorbidities twice odds current smokers mental health conditions despite two mental health comorbidities less likely receive smoking cessation advice absolute differences small conclusion patterns comorbidity associated variation smoking status delivery smoking cessation advice among people chd primary care deprived areas mental health problems considerably likely current smokers require additional smoking cessation support
introduction availability high quality rigorously validated diagnostic tests broadly implemented necessary efficiently identify patients anaplastic lymphoma kinase alk positive nsclc potentially benefit treatment crizotinib present data recently approved ventana alk cdx assay ventana medical systems tucson immunohistochemistry ihc based assay linked treatment outcome methods nsclc specimens prospectively tested anaplastic lymphoma receptor tyrosine kinase gene alk status flourescent situ hybridization fish profile clinical trial crizotinib versus chemotherapy including alk positive alk negative specimens evaluated using alk cdx assay hazard ratios progression free survival comparing crizotinib chemotherapy alk ihc positive patients alk fish positive patients well concordance enrollment alk fish assay determined results results assays obtained cases percent positive negative overall agreement rates respectively discrepant cases alk fishpositive alk ihc negative alk fishnegative alk ihc positive hazard ratios using observed outcomes alk fish positive alk ihc positive cases alk fish positive cases tested alk ihc versus alk fish positive cases enrolled trial outcome data alk fish negative alk ihc positive cases available analysis reader agreement rates alk ihc involving three independent laboratories exceeded conclusions alk cdx assay stand alone companion diagnostic test identification patients treatment crizotinib automated assay provides effective option accurately rapidly identify patients alk positive nsclc simple binary scoring algorithm results high reader reader precision international association study lung cancer published elsevier inc
background limited evidence support use facemasks preventing infection primary care professionals negative effects communication suggested physician wears facemask communication skills doctor patient relationship essential primary care consultations effects doctor facemask wearing explored method randomised controlled study conducted primary care explore effects doctors wearing facemasks patients perception doctors empathy patient enablement patient satisfaction primary care doctors randomized mask wearing non mask wearing clinical consultations public primary care clinics hong kong patients views gathered using consultation relational empathy care measure patient enablement instrument pei overall satisfaction rating scale effects face mask wearing investigated using multilevel hierarchical modelling results patients randomised doctor mask wearing consultations non mask wearing consultations significant negative effect found patients perception doctors empathy care score reduction value established doctor patient relationship effect doctors mask wearing pronounced care score reduction value conclusion study demonstrates doctors wearing facemask consultations significant negative impact patient perceived empathy diminish positive effects relational continuity consideration taken planning appropriate use facemasks infectious disease policy primary care healthcare professionals national local practice level
developing electronic textbook basic chemistry experiment university students reaction mechanisms shown computer graphics cgs chemical reactions made based empirical molecular orbital calculations cgs include following reactions model walden inversion drastic change structure takes place formation butyl alcohol butyl bromide cgs could simultaneously demonstrates nature reaction structural change space filling model ball stick model addition providing image energy change reaction profile electronic textbook also displays picture apparatus flow chart small scale experiment result preliminary study effectiveness included
occurrence entomopathogenic fungi phylloplanes tilia europaea crowns assessed urban parks prevalence fungal infections ladybirds coleoptera coccinellidae collected tilia europaea assessed determine whether fungi found phylloplanes also occurred infections ladybirds isaria spp abundant phylloplanes mean colony forming units cfu per leaf followed beauveria spp cfu per leaf lecanicillium spp cfu per leaf densities inoculum higher inner crowns decreased height although lecanicillium spp peaked upper phylloplane surfaces harboured higher densities isaria spp beauveria spp lower surfaces whereas lecanicillium spp equally distributed prevalent ladybirds isaria spp harmonia axyridis natives lecanicillium spp axyridis natives fewer beauveria spp infections axyridis molecular identification revealed beauveria bassiana pseudobassiana isaria farinosa lecanicillium muscarium among isolates tree ladybird origin tilia europaea phylloplanes support diverse assemblage entomopathogenic fungal species different prevalence coccinellids compared relative abundance habitat leaves urban trees harbour entomopathogenic fungi tree crowns act reservoir fungal infection invasive alien native ladybirds leaves urban trees harbour entomopathogenic fungi tree crowns act reservoir fungal infection invasive alien native ladybirds
wide variety herbal remedies used traditional australian medicine treat inflammatory disorders including autoimmune inflammatory diseases one hundred six extracts native australian plant species traditionally used treatment inflammation inhibit bacterial growth investigated ability inhibit growth microbial trigger ankylosing spondylitis pneumoniae eighty six extracts inhibited growth pneumoniae leichardtii eucalyptus spp flavescens leptospermum spp quinquenervia petalostigma spp angustifolium spinescens australe forte tasmannia spp extracts effective pneumoniae growth inhibitors mic values generally lanceolata peppercorn extracts potent growth inhibitors mic values low extracts examined non biased headspace analysis comparison compound database notable feature high relative abundance sesquiterpenoids polygodial guaiol caryophyllene oxide monoterpenoids linalool cineole alpha terpineol lanceolata peppercorn methanolic aqueous extracts extracts potent pneumoniae inhibitory activity including lanceolata peppercorn extracts nontoxic artemia nauplii bioassay lack toxicity growth inhibitory activity extracts pneumoniae indicate potential preventing onset ankylosing spondylitis minimising symptoms disease established
paper time dependent one dimensional linear advection diffusion equation dirichlet homogeneous boundary conditions initial sine function solved analytically separation variables numerically finite element method observed advection becomes dominant analytical solution becomes ill behaved harder evaluate therefore another approach designed solution decomposed simple wave solution viscous perturbation shown exponential layer builds close downstream boundary discussion comparison solutions carried extensively offering numericist new test model numerical integration navier stokes equation elsevier ltd rights reserved
recently shown austrians associate car front geometry traits way could related face shape geometry mapping overall suites traits yet possible confounding effects familiarity car models media coverage entertainment could ruled order address current study uses cross cultural comparison adult subjects two countries austria ethiopia asked rate person characteristics standardized front views automobiles various trait scales two countries differ substantially regard experience car models brands well car marketing media coverage geometric morphometrics used assess shape information underlying trait attribution car shapes perceived maturity maleness dominance highly similar countries patterns comparable shape changes facial growth humans relative sizes forehead windshield decrease age growth eyes headlights become slit like noses grilles bigger lips air intakes wider austrian participants attributed various degrees interpersonal attitudes emotions whereas neither austrians ethiopians congruently ascribed personalities morphological correlates personal characteristics discussed person perception overgeneralization inanimate objects cross cultural similarities differences addressed well implications car styling follow studies driving pedestrian behavior fundamental dimensions inference human faces elsevier inc rights reserved
original codes combinatorial geometrical computational schemes presented developed applied finding exact analytical formulas describe probability errorless readout random point images recorded scanning aperture limited number threshold levels combinatorial problems encountered course study associated new generalization catalan numbers formulated solved attempt made find explicit analytical form numbers one hand necessary stage solving basic research problem hand independent self consistent problem
astrocyte dysfunction emerges early alzheimer disease may contribute pathology progression recently voltage gated potassium channel subunit underlies fast inactivating currents recognized relevant pathogenesis emerging new target candidate present study investigated vitro vivo models expression functional activity potassium channel subunits astrocytes primary astrocytes biochemical immunohistochemical electrophysiological studies demonstrated time dependent upregulation expression functional activity exposure amyloid beta oligomers consistently astrocytic expression upregulated cerebral cortex hippocampus cerebellum month old mice confocal triple labeling studies revealed month old mice intensely coexpressed beta nonplaque associated astrocytes interestingly cortical hippocampal regions month old mice plaque associated astrocytes much intensely expressed subunits beta important evidenced selective knockdown expression significantly downregulated glial fibrillary acidic protein levels beta trimers brain month old mice collectively results demonstrate expression function channel subunits precociously upregulated cultured astrocytes exposed beta oligomers reactive astrocytes mice elsevier inc rights reserved
droplet particles evaporates particles deposit substrate surface work show extent gravitational effects particle deposition profile propose new model particle tracing evaporating droplet accounts gravitational effects experimentally compare pendant sessile water droplets polystyrene particles numerically finite element method used create transport model evaporating droplet system particle deposition numerical experimental results excellent agreement show pendant water droplet polystyrene spheres significant separation two particle sizes finally phase diagaram created map different deposition profiles various gravitational peclet numbers ratios peclet number damkohler number american institute chemical engineers aiche
erosita space telescope currently developed determination cosmological parameters equation state dark energy via evolution clusters galaxies furthermore instrument development strongly motivated intention first imaging ray sky survey enabling measurements kev erosita scientific payload russian research satellite srg destination launch lagrangian point observational program observatory divides sky survey pointed observations takes total years instrument comprises array identical parallel aligned telescopes seven focal plane cameras equipped pnccd detector enhanced type xmm newton focal plane detector instrumentation permits spectroscopy imaging rays energy band kev kev field view degree camera development done max planck institute extraterrestrial physics key component camera pnccd chip silicon sensor back illuminated fully depleted column parallel type charge coupled device image area micron thick frame transfer ccd comprises array pixels size micron micron readout signal charge generated incident ray photon ccd accomplished asic called erosita camex provides parallel analog signal processing channels multiplexes signals finally one output feeds detector signals fast bit adc read noise system equivalent noise charge electrons rms achieve energy resolution close theoretical limit given fano noise except low energies example fwhm energy kev approximately complete camera assembly comprises camera head detector key component electronics detector operation well data acquisition filter wheel unit addition chip light blocking filter directly deposited photon entrance window pnccd external filter moved front sensor serves also contamination protection furthermore board calibration source emitting several fluorescence lines accommodated filter wheel mechanism purpose orbit calibration since spectroscopic silicon sensors need cooling degrees mitigate best radiation damage effects elaborate cooling system necessary consists two different types heat pipes linking seven detectors two radiators based tests engineering model flight design developed camera qualification model built tests performance camera presented following conclusion outlook flight cameras given
objectives young adults transition childhood dental care adult dental care without problems however substantial minority leaves childhood dental care considerable fear dental treatment present study hypothesized fear dental treatment young adult influenced memories positive negative childhood experiences dental care specifically predicted emotional impact sense reliving rehearsal belief accuracy negative treatment memory would associated increased dental fear positive treatment memories would show opposite relation methods one hundred thirty six young adults leaving childhood dental care responded online measures dental fear negative positive memory dental treatment symptoms posttraumatic stress disorder results negative memories events involved pain dentist behaviors impatience scolding frequently described significantly associated dental fear symptoms posttraumatic stress positive memories frequent show consistent relationship dental fear conclusions importance negative memories suggests avenue intervention dental fear focuses restructuring memories emphasize positive aspects
inter american court human rights court ruled supreme court costa rica judgment prohibiting vitro fertilization ivf violated human right private family life human right found raise family human right non discrimination grounds disability financial means gender court conclusions violations contrary american convention human rights followed ruling convention vitro embryos persons possess right life accordingly prohibition ivf protect embryos constituted disproportionate unjustifiable denial infertile individuals human rights court distinguished fertilization conception since conception unlike fertilization depends embryo implantation woman body human rights law legal protection embryo conception inapplicable creation fertilization completion implantation utero international federation gynecology obstetrics published elsevier ireland ltd rights reserved
feedback indicating well students performing learning task stimulating study pre post test design effects two types performance feedback learning results compared feedback learning task either stated terms well students performing relative students social comparison feedback relative absolute criterion criterion based feedback thirty four students secondary vocational engineering education randomly assigned one two conditions conditions students worked together small groups groups completed math learning task received either social comparison feedback criterion based performance feedback findings showed type feedback strong effect learning outcomes post test scores gains students social comparison condition significantly higher students criterion based feedback condition
thermodynamic processes complex phenomena understood set successive stages treating processes classical thermodynamics particularly gibbsian formulation predominantly used chemistry pays attention initial final states however reintroducing notion process absolutely necessary get know final state initial state conditions general complex concepts better understood visualization nowadays computer graphics used simulate processes initial final states including interactivity time progression technology report attempts illustrate benefits use computer graphics may provide learning classical thermodynamics work shows interactive graphic animations may used dynamically study thermodynamic processes report illustrates key concepts thermodynamic process reversibility irreversibility easily introduced students visualization interactivity goal tested programming environment called processing widely used context visual arts create images animations interactions processing software development environment four major advantages free charge open source easy use multiplatform oriented get immediate visual feedback programming
backgrounddespite recent advances investigation myeloproliferative neoplasms mpn impact genetic heterogeneity molecular pathogenesis fully elucidated thus study aim characterize genetic complexity korean patients polycythemia vera essential thrombocythemia methodswe conducted association studies using single nucleotide polymorphisms snps patients controls whole genome sequencing performed six patients two jak four wild type jak putative somatic mutations validated patients clinical laboratory characteristics also analyzed resultsseveral germline snps haplotype significantly associated three somatic mutations mpdz iqch calr genes selected validated frequency calr mutation patients carry jak mpl mutations moreover compared jak positive patients calr mutations showed lower hemoglobin hematocrit levels respectively higher platelet counts lower frequency cytoreductive therapy conclusionthis study first comprehensive investigation genetic characteristics korean patients found somatic mutations haplotype contribute pathogenesis korean patients
paper construct lattice based threshold multi stage secret sharing msss scheme according ajtai construction one way functions msss scheme authorized subsets participants recover subset secrets stage secrets remain undisclosed paper secret vector dimensional lattice basis lattice kept private subset participants recover secret using assigned shares using lattice based one way function even secrets revealed computational security unrecovered secrets provided quantum computers scheme multi use sense share new set secrets sufficient renew public information new share distribution longer required furthermore scheme verifiable meaning participants verify shares received dealer recovered secrets combiner using public information
objectives compare role alpha blocker tamsulosin monotherapy anticholinergic tolterodine monotherapy combination drugs versus analgesics improving post ureteroscopy urs lower urinary tract symptoms related double ureteral stent patients methods january june consecutive patients ureteric stones included study tertiary care centers patients randomized groups group received tamsulosin day group received tolterodine day group received tamsulosin tolterodine day group control group received placebo day patients received analgesics demand pre treatment evaluation done followed among groups comparison days including ureteral stent symptom questionnaire ussq urinary symptom index usi pain symptom index psi general health index ghi work perform index wpi need pain killer need analgesia visual analogue scale vas pain quality life qol side effects recorded compared
cosmetic skin care products currently market demonstrate increasing trend toward antiaging products selection right formulation approach key successful consumer acceptance nanostructured lipid carriers nlcs dermal application render added benefits formulation tretinoin derivative vitamin retinoid anti aging anti acne potential present study aimed formulating nlcs tretinoin reducing skin irritation potential increasing drug loading capacity prolonging duration action nlcs optimized using response surface methodology based particle size preliminary study suggested use stearic acid oleic acid tween span solid lipid liquid lipid surfactants respectively formed stable dispersion nlcs tretinoin prepared hot melt microemulsion hot melt probe sonication methods properties optimized nlcs morphology size zeta potential stability vitro drug release investigated tretinoin loaded nlcs carbopol gel showed sustained release pattern isopropyl alcohol receptor fluid compared marketed gel using franz diffusion cells eight prepared gel formulations tested found follow higuchi model drug release stability studies indicated formulations stored refrigeration room temperature showed noticeable differences drug content release profiles vitro period weeks vivo skin irritation test male wister rats indicated irritation erythema application nlcs loaded gel repeated period days compared application marketed tretinoin gel showed irritation slight erythema within days results showed irritation potential tretinoin reduced drug loading increased drug release prolonged incorporation nlcs elsevier rights reserved
rationale objectives process education involves variety repetitious tasks believe appropriate computer tools automate many chores allow educators students devote lot time actual teaching learning paper details tools used automate broad range academic radiology specific tasks mac ios windows platforms tools describe require little expertise time use others require basic knowledge computer programming materials methods used textexpander mac ios autohotkey win automated generation text files resident performance reviews radiology interpretations custom statistical calculations performed using textexpander python programming language workflow automated note taking developed using evernote mac ios win hazel mac automated resident procedure logging accomplished using editorial ios python created three variants teaching session logger using drafts ios pythonista ios editorial drafts used create flashcards knowledge review developed mobile reference management system ios using editorial used workflow app ios automatically generate text message reminder daily conferences finally developed two separate automated workflows one evernote mac ios win one python mac win generate simple automated teaching file collections results beta tested workflows techniques scripts several fellow radiologists expressed enthusiasm tools able use one automate educational activities conclusions appropriate computer tools automate many educational tasks thereby allow educators students devote lot time actual teaching learning
prenatal stress lasting effect women mental health childbirth negative effects may particularly salient women low income ethnic minority backgrounds increased risk postpartum depression however social support may potential attenuate negative impact stress present study evaluated mexican american women ages spanish speaking median income prenatal stress daily hassles family stress partner stress culture specific stress relation depressive symptoms weeks postpartum prenatal social support examined buffer impact prenatal stress partner stress family stress daily hassles uniquely predicted depressive symptoms moderate high levels social support attenuated risk depression due family stressors prenatal interpersonal daily stressors negatively impact mental health women birth social support mitigate effects among mexican american pregnant women effective interpersonal support stress management may associated reduced risk postpartum depression
present refined entanglement concentration protocol ecp arbitrary unknown less entangled four electron spin cluster state exploring optical selection rules derived quantum dot spins one sided optical microcavities ecp parties obtain four electron spin systems partial entanglement two unknown parameters also less entangled two electronspin systems first step utilizing preserved systems resource second step ecp parties obtain standard cluster state keeping robust odd parity instances two parity check gates meanwhile systems rest three instances used resource next round ecp success probability ecp largely increased iteration ecp process moreover coefficients ecp unknown parties without assistance extra single electron spin ecp maybe good applications quantum communication network future
free piston linear generators fplgs attractive application prospects hybrid electric vehicles hevs owing high efficiency low emissions multi fuel flexibility order achieve long term stable operation hybrid system design full cycle operation strategy essential factors considered fplg consisting internal combustion engine ice linear electric machine lem gas spring designed improve power density generating efficiency lem assembled two modular flat type double sided lem units sandwich common moving magnet plate supported middle keel beam bilateral slide guide rails enhance stiffness moving plate convenience operation processes analysis coupling hybrid system modeled mathematically full cycle simulation model established top level systemic control strategies including starting stable operating fault recovering stopping strategies analyzed discussed analysis results validate system run stably robustly proposed full cycle operation strategy effective electric output power reach overall system efficiency
paper presents development wireless flow transmitter using rotameter operational amplifier based signal conditioning circuit rotameter linear gravity based flow measuring device consists display unit directly displays flow rate industrial applications new circuitry required transmit measured flow rate control unit remote areas ferromagnetic wire attached float rotameter acts core inductance pickup coil constitutes flow sensor self inductance coil changes according change flow rate operational amplifier based circuit used measurement self inductance voltage corresponding flow rate finally converted current wireless readout provided using microcontroller unit bluetooth module results show linear relation variation self inductance pickup coil well transmitter output respect flow rate theoretical equations simulation results added paper
background partnership yale university usa kazan state medical university ksmu russia established transitioned western connecticut health network wchn university vermont robert larner college medicine usa goal modernizing medical education ksmu primarily introduction american medical education structure role modeling educational capacity building centered formation select group russian junior faculty members familiar american medical education would initiate gradual change medical education ksmu describe year partnership rooted local capacity building sustainable mutually rewarding international collaboration established addition evaluate program outcomes impact medical education kazan state medical university assess influence russian program participants methods senior residents faculty sent ksmu conduct teaching sessions local faculty trainees responsibilities included familiarizing russian colleagues specific topics clinical medicine importing knowledge basics teaching clinical epidemiology evidence based medicine creating consistency american model clinical teaching team structure integrates patient care clinical education furthermore selected ksmu members including junior faculty clinical phd students interns residents five medical students trained yale wchn one major affiliated community hospitals period months total participant weeks training results thirty individuals trained currently working kazan primarily faculty ksmu among three trainees become heads department eight hold senior faculty positions two clinical educational administrative leadership positions two major clinical departments adopted clinical teaching team structure result collaboration three teaching courses evidence based medicine tropical medicine hiv aids medicine designed incorporated curriculum conclusion partnership instrumental introducing american medical education model expanding medical knowledge faculty residents students ksmu infectious diseases hiv aids tropical medicine renal diseases global health topics capacity building yale wchn ksmu exchange program greatly contributed quality medical education kazan state medical university
bivalve mollusks among aquatic bioindicators commonly used monitoring water pollution studies thanks behavior metabolism directly affected level pollution given site research study biological response gills hepatopancreas muscles indigenous mussels mytilus galloprovincialis used monitoring emissary pollution four polluted sites coastal environment casablanca seasonal variations activity antioxidant defence enzymes catalase cat glutathione transferase gst well lipid peroxidation measured biomarkers within one year period compared mussels unpolluted sampling site study completed analysing series abiotic factors temperature conductivity chemicals heavy metals seawater result showed availability metallic contamination environmental stress conditions causes relatively oxidative stress species station studied pollution level clearly varies according sampling campaign furthermore revealed significant increase gst activities concentrations significant decrease cat activities mussels collected sites industrial contamination negative correlation suggested organisms location exposed relatively higher level oxidative stress first study area confirm variations antioxidant defence enzymes activities concentrations mussels could used prospective biomarkers toxicity environmental monitoring programs elsevier ltd rights reserved
full potential computation electronic magnetic elastic thermodynamic properties cumga alloys performed stable phase equilibrium lattice parameter cucrga cuvga stable state application mbj potential also found energy gap alloys either spin channels hence metallic total partial density states second order elastic constants combinations computed show electronic magnetic stability brittle ductile nature alloys reported first time cauchy pressure pugh index predict cucrga brittle cuvga ductile materials stiff enough break found compounds anisotropic ferromagnetic metallic nature used quasi harmonic approximations study pressure temperature variation thermodynamic properties alloys
paper proposes khn equivalent biquad using third generation current conveyor cciii proposed current mode filter circuit derived adjoint signal flow graph corresponding classical khn filter proposed multi input single output biquad offers advantages khn biquad derived circuit realize five responses low pass high pass band pass pass band stop without need additional active passive component validate circuit workability software simulations done using pspice non ideal analysis sensitivity analysis filter circuit also shown paper
sometimes data belonging relational databases need transferred nosql ones however data conversion process relational nosql databases considered trivial since necessary considerable knowledge data models hand regarding structural heterogeneity underlying problem propose approach named rnosql defines conceptual mappings enhance data conversion process paper present approach implementation experimental results show using defined conceptual mappings obtain consistent target nosql database respect source relational one
objective use different drug patients sports injuries clinical control treatment comparing efficacy drugs methods cases joint motion injury patients randomly divided two groups treatment group exceptional massage garlic essential balm applicator patients injured area control group cases topical applicator safflower oil massage wet injury affected area times day week course treatment efficacy results treatment group control group significant difference treatment group control group conclusion according anti inflammatory analgesic balm garlic scattered gas swelling features reasonable use treatment sports injuries practice unique effect effect significant higher value
paper presents results large scale numerical modeling cellular mattress reinforced fly ash beds overlying soft clay using finite element program cellular mattress honeycomb structure consisting interconnected multiple circular cells influence height diameter tensile stiffness cell width entire mattress pressure settlement response footing surface deformation footing settlement mobilization hoop tension cell walls illustrated results numerical analyses indicate improvement footing capacity approximately times greater fly ash bed inclusion single geotextile separator representing jute geotextile fly ash bed underlying clay cellular mattress fly ash composite bed produced approximately sevenfold increment footing capacity compared unreinforced fly ash bed presence jute separator mattress reinforced beds produced better footing capacity increase height width mattress tensile stiffness cell wall satisfactory acquire optimization height width mattress tensile stiffness cell wall particular mattress width height footing capacity increased reduction cell diameter cell mattress center mobilized maximum hoop tension lesser cells successively toward mattress periphery also hoop tension mobilized increase tensile stiffness cell wall small scale finite element models created using material models properties used large scale modeling validate program laboratory small scale model tests comprising model conditions finite element results found good agreement experimental results
preventing voltage waveform distortion multifrequency current control saturated operation difficult problem far partially solved paper scheme based principle realizable references proposed converter enters saturated operation algorithm recalculates converter current reference unsaturated operation returns converter voltage reference exceed space vector modulation hexagon distortion thereby avoided integrator windup
milling crucial step producing restorations using computer aided design computer aided manufacturing cad cam systems study trueness currently available milling devices evaluated thirty clinical cases ten inlays ten crowns ten onlays milled ceramic blocks using four different milling approaches five axis imes coritec four axis cerec mcxl four axis cerec mcxl five axis inlab mcx milled restorations scanned occlusal inner surfaces compared originally calculated surface using difference analysis software percentile distances calculated analysed using one way anova post hoc scheff test alpha chipping marginal areas visually examined analysed using one way anova post hoc tamhane test alpha inner surfaces milling trueness imes mcxl significantly better mcxl occlusal surfaces mcxl showed significant higher accuracy mcxl imes produced chipping five axis milling devices yield high trueness mcxl competitive may allow chairside fabrication good milling results accurate milling required well fitting restorations thereby requires fewer manual finishing steps yields smaller marginal gaps resistance secondary caries longevity restorations
jumping negative conclusions people traits judged morally bad many people despite across six experiments total find multiple types moral evaluationseven evaluations related open mindedness tolerance compassionplay causal role potentially pernicious trait assumptions results also indicate moralization affects negativebut positivetrait assumptions effect morality negative assumptions explained merely people general nonmoral preferences factors distinguish moral nonmoral traits controllability desirability together results suggest one destructive human tendenciesmaking negative assumptions otherscan caused better angels nature
development addiction associated dysregulation glutamatergic transmission brain reward circuit isoform calcium calmodulin dependent kinase alpha camkii one key proteins regulates structural functional plasticity glutamatergic synapses alpha camkii activity controlled autophosphorylation threonine role autophosphorylation regulation addiction related behaviors proposed still poorly understood using alpha camkii autophosphorylation deficient mutant mice show comparison wild type animals less resistant high doses alcohol show psychostimulant response neither alcohol injections voluntary alcohol drinking mutants also less prone develop alcohol addiction related behaviors including increased motivation alcohol persistent alcohol seeking withdrawal alcohol consumption relapse finally demonstrate alpha camkii autophosphorylation regulates also alcohol induced remodeling glutamatergic synapses hippocampus amygdala conclusion data suggest alpha camkii autophosphorylation dependent remodeling glutamatergic synapses plausible mechanism regulation alcohol addiction related behaviors
objective digestive symptoms reported result wide range dietary components dietary pattern analysis useful method considering entire diet rather individual foods nutrients providing opportunity take interactions account aim present study investigate using dietary pattern approach relationship diet digestive symptoms health related quality life hrqol women reporting minor digestive symptoms methods analysis performed dietary digestive symptoms data collected france women ages reporting bowel movement frequency within normal range stools minor digestive symptoms previous month studied dietary data collected using three recalls means used divide dietary data clusters frequency digestive symptoms abdominal discomfort pain bloating flatulence borborygmi bowel movements evaluated period hrqol also assessed results four dietary clusters identified characterized unhealthy balance healthy convenience differences found frequency digestive symptoms according dietary cluster except flatulence prevalent unhealthy convenience clusters significant differences observed hrqol according dietary clusters conclusions results present study demonstrated even within relatively homogeneous sample french women distinct dietary patterns identified without significant differences digestive symptoms except flatulence hrqol elsevier inc rights reserved
bladder related issues nocturnal enuresis incontinence long part general pediatric practice increasingly clinicians prescribing medications directed variety types bladder dysfunction prior population based data exist used marketscan health care claims data insured children estimate utilization patterns age sex year geographic region united states assess related diagnosis codes approximately children filled antimuscarinic prescription common prescriptions oxybutynin tolterodine rates highest ages years person months higher girls versus boys peaked person months highest midwest person months seventy three percent children prescriptions diagnosis codes genitourinary symptoms codes congenital anomalies research needed regarding comparative effectiveness safety drugs children
synthetic insulin analogues long lifetime current drug targets therapy diabetic patients replacement interchain disulfide diselenide bridge resistant reduction internal bond rotation enhance lifetime insulin presence insulin degrading enzyme ide without impairing hormonal function variant bovine pancreatic insulin bpins successfully prepared using two selenocysteine peptides analogues chains respectively buffer solution spontaneously assembled thermodynamic control correct insulin fold selenoinsulin ins exhibited bioactivity comparable bpins interestingly degradation ins ide significantly decelerated approximate approximate bpins lifetime enhancement could due intrinsic stability diselenide bond local conformational changes induced substitution
leadership energy environmental design leed widely used international green building certification program developed green building council usgbc although need leed certification grown significantly leed managers still face challenges target credit selection green building technology design frequently meet new types projects different project characteristics requirements therefore would helpful leed managers could refer similar certified green building cases planning designing leed projects however supported current studies research paper proposes case based reasoning cbr approach provide case studies similar certified green building projects suggestions target leed credits currently linear formation local global method commonly used retrieval step cbr paper presents non linear formation local global retrieval based artificial neural network ann provide higher accuracy leed new construction leed focus paper leed certified cases collected case base pairwise comparison conducted generate local distance attribute similarity target training ann model proposed non linear cbr approach tested evaluated using recently certified projects results showed prediction accuracy leed credit selection results also compared calculated commonly used linear cbr approaches multiple regression analysis correlation analysis approach accuracy achieved methods lower proposed approach elsevier ltd rights reserved
patient reported outcomes measurement information system promis tools identify health related quality life hrqol domains could differentially affect disease progression cirrhotics highly prone hospitalizations hospitalizations current clinical prognostic models may insufficient thus studying contribution individual hrqol domains could improve prognostication analyze impact individual hrqol promis domains predicting time non elective hospitalizations hospitalizations cirrhosis outpatient cirrhotics administered promis computerized tools first non elective hospitalization subsequent hospitalizations enrollment recorded individual promis domains significantly contributing toward outcomes generated using principal component analysis factor analysis revealed three major promis domain groups daily function fatigue physical function social roles activities sleep issues mood anxiety anger depression pain pain behavior impact accounted variability cox proportional hazards regression modeling used groups evaluate time first hospitalization hospitalization total patients years meld men hepatic encephalopathy enrolled patients followed month mth intervals median mths iqr hospitalized median iqr mths hospitalized mths time first hospitalization predicted daily function promis group independently contrast pain promis group predictive time hospitalization daily function pain hrqol domain groups using promis tools independently predict hospitalizations hospitalizations cirrhotic patients
report experimental elicitation nonbelieved memories childhood events adults study children study using modified false memory implantation paradigm participants received true trip theme park false hot air balloon ride narratives recalled events interviews debriefing adults children reported nonbelieved memories phenomenal ratings higher true nonbelieved memories immediately debriefing month nonbelieved memories behaved true memories also following debriefing adults children retracted false memory claims prior debriefing participants nonbelieved memories likely indicate remembering event whereas participants false memories retracted claim likely endorse believing remembering event research suggests debriefings previous false memory studies lead development nonbelieved memories additional findings regarding correspondence subjective belief subjective memory objective memory judgments prior following debriefing discussed
soluble receptor advanced glycation end products srage decoy toxic ages considered protective factor study aimed evaluate correlation intrafollicular srage levels clinical outcomes infertile women young advanced maternal age ama undergoing vitro fertilization ivf total young women ama women would undergo ivf included prospective study intrafollicular srage concentration measured determine association number retrieved oocytes fertilized oocytes high quality embryos achievement clinical pregnancy young ama women respectively besides correlations srage age follicle stimulating hormone fsh examined found intrafollicular srage levels higher young patients ama patients suggesting srage levels inversely correlated age young patients srage showed correlation number retrieved oocytes fertilized oocytes high quality embryos achievement clinical pregnancy found ama patients retrieved oocytes fertilized oocytes high quality embryos demonstrated higher srage levels prognostic factor getting clinical pregnancy independent age fsh level conclusion srage levels decrease age elevated intrafollicular srage levels indicate good follicular growth fertilization embryonic development successful clinical pregnancy ama women young women role srage may predominant
although many clinical studies shown low testosterone level associated cardiovascular diseases role androgens cardiovascular physiology pathophysiology remains controversial androgens exert various actions target organs androgen receptor widely distributed several tissues including endothelial cells smooth muscle cells fibroblasts vascular system biological activities androgens predominantly mediated transcriptional control target genes interaction multiple signaling pathways clarify molecular mechanisms androgens cardiovascular disease examined pathological model using knockout mice showed androgen system protective effects cardiovascular remodeling cardiovascular stress review focus role androgen system angiogenesis ischemic stress
ever increasing usage internet availability digital data tremendous demand context essential protect ownership data able find guilty user paper fingerprinting scheme proposed provide protection numeric relational database rdb focuses challenges like minimum distortion numeric database usability preservation non violation requirement blind decoding digital data concern numeric nature usability data needs keenly preserved made possible achieving minimum distortion
present innovative image based modeling technique based google earth like algorithms effectively resolve intricate material morphology address computational complexity associated heterogeneous materials sharp volumetric billboard algorithm stems volumetric billboard method multi resolution modeling strategy computer graphics work enhance volumetric billboards sharpening filter reconstruct statistical information heterogeneous systems hierarchy microstructures created high energy ball milled composites analyze first second order statistics microstructures characterize macro micro mechanical material responses furthermore conduct convergence study associated computational results statistical mechanical robustness data compression demonstrated corresponding error analysis elsevier ltd rights reserved
esophagitis dissecans superficialis eds rare desquamative disorder esophagus characterized sheets sloughed squamous tissue normal underlying mucosa present case year old man severe anemia positive fecal occult blood test found features suggestive eds endoscopy however histological features suggestive eds fungal esophagitis knowledge first reported case literature discusses clinical scenario fungal infection possible etiology rather commonly accepted differential diagnosis eds also review clinical features diagnostic criteria treatment eds
ambient assisted living aal technologies potential target challenges aging population however little known motivates older adults adopt new technologies research area relies single cases specific aal application limited number users fill gap content analyses aal reports conducted aim provide comprehensive overview potential incentives using aal technologies data coded using social cognitive theory sct total incentives could identified grouped six categories social incentives health safety incentives activity incentives novel sensory incentives status incentives self reactive incentives within categories social connectedness health safety important incentives results provide comprehensive theoretically grounded understanding motivates older adults adopt aal technologies
purpose limited data available anal squamous intraepithelial lesions asils anal human papillomavirus hpv infection young black populations purpose study examine prevalence relationships asils high risk hpv infection young years age predominantly black men sex men msm population methods results anal cytology hpv dna gathered individuals results forty two percent individuals atypical squamous cells undetermined significance low grade squamous intraepithelial lesion cytology tested positive high risk hpv subtypes conclusion low rates infection hpv types may provide evidence continue vaccinate young black msm hpv
work presents two implementation attacks cryptographic algorithms based two presented attacks thesis shows assessment physical attack complexity error prone hence cryptography rely cryptographic technologies protected implementation attacks already realized development countermeasures require successful execution attack already carried soon principle side channel fault attack understood
stress distribution known rotating flow near ground fluid mechanics indicates horizontal aerodynamic entrainment particles within dust devils attributed friction force rather pressure force expression dust emission rate earth theoretically discussed based simulated flow field current understanding physics aeolian dust seems transition flow vital dust devils mars elsevier inc rights reserved
wilms tumor gene useful marker clonal hematopoiesis shown good marker residual disease reflects response therapy although myelofibrosis characterized mutations jak calreticulin calr mutations useful monitor response therapy study demonstrated patients affected myelofibrosis correlates international prognostic scoring system ipss score diagnosis furthermore good marker response jak inhibitors especially patients without blasts patients develop anemia thrombocytopenia progression therapy related toxicity finally transcript reduction mirror benefit therapy disease burden study demonstrated good marker monitoring response therapy patients affected myelofibrosis
active control based nonlinear model predictive control nmpc methodology applied candidate realistic dual coaxial cylinder wave energy extractor system objective maximizing energy capture range incident ocean wave conditions extractor consists outer cylinder floater moving relative tension tethered inner cylinder driving permanent magnet linear generator pmlg acquire power take pto floater dynamics solved time domain nmpc constrain maximum floater motion simultaneously incorporating pmlg damping capability numerical model coupled floater pto dynamics formulated state space representation mechanical electrical conversion efficiency pmlg experimentally determined function power extraction damping considered numerical simulation nmpc process yields time varying profile generator damping control strategy simulation results indicate strongly time dependent discontinuous generator damping requirements regular irregular incident wave scenarios however nmpc controlled system significantly outperforms passive control constant damping system exhibiting higher peak values energy extraction broader capturing bandwidth thus confirming feasibility success control strategy elsevier ltd rights reserved
article describes development characterization synergistic smart morphing aileron concept leverages properties two different smart material actuators achieve performance exceeds constituent materials utilizing relatively higher work density phase transformation shape memory alloys combined larger bandwidth conformal bending bonded piezoelectric macro fiber composites resultant synergistic morphing design improves range static tip deflections enabling capability hold trim positions long timescales still quickly compensating dynamic loading commanding input full range square waves actuators first order time responses measured characterized using common methodology tracking relative time constant using method aeroelastic effects actuator combined system characterized wind tunnel degrees angle attack flow speeds ranging novel approach characterized large deflection morphing actuation system multiple smart materials operating different timescales combined system achieved additive amplitude tracking faster actuation response macro fiber composite
modeling brain disorders always one key tasks neurobiological studies wide range organisms including worms fruit flies zebrafish rodents used modeling brain disorders however whether complicated neurological psychiatric symptoms faithfully mimicked animals still debatable review discuss key findings using non human primates address neural mechanisms underlying stress anxiety behaviors well technical advances establishing genetically engineered non human primate models autism spectrum disorders disorders considering close evolutionary connections similarity brain structures non human primates humans together rapid progress genome editing technology non human primates indispensable pathophysiological studies exploring potential therapeutic methods treating brain disorders
patient female final diagnosis iliopsoas abscess symptoms fever medication clinical procedure specialty infectious diseases objective rare disease background uncommon iliopsoas abscesses become underlying cause fever unknown origin even cases considered rare iliopsoas abscess extend subcutaneous space case report year old woman history schizophrenia referred hospital high grade fever patient unaware febrile status prior admission previous hospital admission examination revealed non tender mass lower right back patient aware approximately month initially considered subcutaneous abscess however computed tomography detected large mass right retroperitoneum extended adjacent subcutaneous space surgical drainage performed morganii detected fluid evacuated abscess urine culture blood cultures negative repeat enhanced revealed right renal abscess staghorn calculus iliopsoas abscess considered due renal abscess combination minimally aggressive bacterial species absence disease awareness resulted uncontrolled abscess growth case surgical drainage salvage nephrectomy subsequently performed discharged nursing home conclusions morganii lead massive abscess formation without underlying immunocompromised status iliopsoas abscesses surreptitiously extend subcutaneous space therefore abscesses observable surface necessarily subcutaneous origin
article leads concept data visualization huge amounts news data design implements system news data visual system ndvs news gathering analysis structured storage visual analysis system ndvs collects news data schedule time seeds website web spider written java every day structured documents processed analyzed detached parameters url classify news saved distributed database nosql mongodb web visually interactively animate documents means design realization ndvs emphasized article find ndvs good capability lots clients concurrent access believe ndvs become useful tool news media works system follows usability policy helps people find potential tendency news development guide public opinion stage visualization design
well known japan successfully dealt severe water pollution caused rapid economic growth lessons learned japan technological developments emerged policy measures japan devised cope pollution shared widely asian countries face severe water pollution associated economic growth however information basically qualitative nature paper discuss potential using patent data perform analyses substantiate insights data yield order provide quantitative information historical trends development essential technologies field specifically demonstrate approach using patent data verify historical development wastewater sewage sludge treatment technologies past years japan examined relevant patent data onward addressed technological development trends relation societal changes implementation governmental policies period example substantiating analysis applied principal component analysis text mining review trends systematic manner demonstrate emergence developments closely associated societal background factors adoption relevant governmental policies argue kind patent data analysis coupled essential data yield clues evolution relevant technologies past leading useful implications environmental management economically developing nations elsevier rights reserved
background hereditary angioedema hae rare autosomal dominant primary immunodeficiency complement system defect characterized recurrent episodes angioedema involving skin mucosa upper respiratory gastrointestinal tracts objective characterize clinical laboratory data hereditary angioedema iran methods patients probable diagnosis angioedema enrolled study demographic clinical data documented designed questionnaire including history attacks triggering factors laboratory data esterase inhibitor level function results among patients clinically suspicious angioedema males females cases diagnosed hae among hae patients diagnosed hae type five patients diagnosed hae type mean ages hae type type patients years mean age onset hae type group years hae type group years mean diagnosis delay years hae type patients years hae type common clinical manifestation facial swelling presented hae patients followed swelling extremities present patients hae conclusion clinical criteria iranian patients hae consistent known clinical patterns disease
csp solar fields designed lightweight structures nevertheless due size complexity large amounts materials required environmental conditions like wind loads key driver design solar fields including required strength materials therefore mass give solid example structural steel work solar field aperture parabolic trough plant typical plant spain thermal storage amounts approx tons steel due changes european design codes respective loading conditions design wind speed increased increases solar field structural steel mass tons obviously prescribed load conditions tremendous effect steel mass hence cost environmental impact unfortunately load description many tender specifications insufficiently accurate often results confusion even significant errors planning construction higher risks paper describes various environmental loading effects mainly wind parabolic trough heliostat collector fields published elsevier ltd
recognizing construction assets materials equipment labor point cloud data construction environments provides essential information engineering management applications including progress monitoring safety management supply chain management quality control study introduces novel principal axes descriptor pad construction equipment classification point cloud data scattered point clouds first processed downsampling segmentation clustering steps obtain individual instances construction equipment geometric descriptor consisting dimensional variation occupancy distribution shape profile plane counting features calculated encode three dimensional characteristics equipment category using derived features machine learning methods nearest neighbors support vector machine employed determine class membership among major construction equipment categories backhoe loader bulldozer dump truck excavator front loader construction equipment classification proposed pad validated using computer aided design cad generated point clouds training data laser scanned point clouds equipment yard testing data recognition performance evaluated using point clouds construction site well pose variation data set pad shown achieve higher recall rate lower computation time compared competing descriptors results indicate proposed descriptor viable solution construction equipment classification point cloud data american society civil engineers
unintended pregnancies negative consequences mother child focus study utilize perceived behavioral control measures pbc part theory planned behavior identify relevant behavioral determinants birth control use study also tested associations direct indirect pbc measures intention birth control use intention birth control use methods included randomly selected sample patients health care system upper midwest sent self administered survey non pregnant women returning completed surveys participants indicated high level control using birth control significant positive correlation observed direct indirect pbc measures participants also reported high intentions use birth control significant positive correlation observed intention pbc additionally pbc measures intention independently significantly associated behavior pbc remained significantly associated behavior intention added model conclusion compared previous literature study unique examines indirect pbc measures also important role pbc plays actual birth control behavior
wireless sensor networks wsns contain multiple nodes configuration type biggest challenge nowadays communicate heterogeneous nodes different wsns communicate distinct networks application requires generic middleware middleware able translate requests contrary wsns wireless nodes use tinyos contiki operating systems operating systems vary architecture configuration programming model application communicate heterogeneous networks divergent nature paper design implement tinyco generic middleware model wsns overcomes challenges tinyco general purpose service oriented middleware model middleware model identify heterogeneous networks based tinyos contiki allows applications communicate networks using generic request middleware interprets given input signatures underlying networks proposed middleware implemented java tested telosb motes
paper compares vapour ejector electric vacuum pump power consumptions machine learning algorithms using real process data presents novelty guideline selection appropriate condenser vacuum pump system steam turbine power plant machine learning algorithms made using supervised machine learning methods artificial neural network model local linear neuro fuzzy models proposed non linear models designed using wide range real process operation data sets chp system thermal power plant novelty guideline selection appropriate condenser vacuum pumps system expressed comparative analysis energy consumption use specific energy capable work furthermore novelty expressed economic efficiency analysis investment taking consideration operating costs vacuum pump systems may serve basic guidelines selection appropriate condenser vacuum pump system steam turbine elsevier ltd rights reserved
purpose impact interprofessional faculty development fellowship fdf pharmacy graduates careers described summary fdf instructional approach longitudinal acquisition application knowledge skills attitudes fostered clinical care delivery teaching experiences structured reflection giving receiving feedback research scholarly projects leadership development exercises interprofessional fdf fellows teach learn provide care together inpatient outpatient clinical settings part evidence based medicine curriculum providing educational sessions medical students pharmacy students medical residents attending family medicine physicians clinical pharmacy faculty throughout year twenty seven pharmacist graduates fellowship response rate responded electronic survey influence fdf careers overall pharmacy graduates satisfied fellowship fellowship fostered clear pattern continued collaborative learning additional training beyond pharmacy residency program necessary successful clinical career graduates pursued additional training completing fellowship open ended responses motivations completing fdf influences fdf careers fell unforced fdf curriculum domains reinforced belief right areas target development conclusion pharmacy residents participated broad interprofessional faculty development curriculum fostered teaching scholarship leadership professional development clinical skills pharmacist graduates indicated experience significantly influenced careers professional development
previous studies shown female infidelity attachment insecurity male sexual coercion intimate relationships empirically related however mechanisms involved remain poorly understood study aimed examine two mediating models male sexual coercion concerning first sex chinese college students dating relationships perceived female infidelity attachment insecurity mediator male female participants using dyadic data total validly completed questionnaires provided data respondents recruited purposive snowball sampling students attending colleges five china largest cities currently romantic relationship first male female samples perceived female infidelity positively correlated violence threat coercive tactics male sample positively correlated emotional manipulation coercive tactics second male sample male partners attachment insecurity anxiety avoidance positively correlated perceived female infidelity third male partners attachment anxiety fully mediated relationship perceived female infidelity emotional manipulation coercive tactics findings suggest proximate ultimate causes sexual coercion intimate relationships interact implications clinical practice discussed elsevier ltd rights reserved
matrix metalloproteinase mmp important target cancer treatment due critical roles tumor invasion metastasis previous failures compound based broad spectrum mmp inhibitors clinical trials suggest selectivity key successful therapy inherent high specificity monoclonal antibodies mabs therefore arise attractive inhibitors able target particular mmp interest routine screening method enzyme linked immunosorbent assays elisa applied panned phage libraries isolation mabs inhibiting mmp however suboptimal growth conditions insufficient antibody expression associated monoclonal elisa considerable number potentially inhibitory clones might identified taking advantage next generation sequencing ngs monitored enrichment profiles millions antibody clones along three rounds phage panning identified fab inhibitors mmp inhibition values among inhibitory fabs found monoclonal phage elisa particularly fab exhibited inhibition potency excellent selectivity mmp mmp inhibition kinetics epitope mapping suggested competitive inhibitor directly bound vicinity mmp catalytic site study demonstrates deep sequencing powerful tool facilitate systematic discovery mabs protease inhibition functions biotechnol bioeng wiley periodicals inc
actual software project feasibility assessment one foremost challenging vital activities estimating economics software actual development therefore prototyping recent years gradually become approach decide various options possible outcomes real implementation success projects prototype studies software engineering acts good pointer envision reflect upon final product prediction however dearth far detailed economic analysis accountable benefits opportunities risks costs bocr merits arising various influencing factors criteria sub criteria determine final possible outcomes alternatives trade offs bocr models present work attempts close gap modeling performed association two types models analytic network process anp analytic hierarchy process ahp complex relations influencing factors former illustrated bocr anp form control network analysed questionnaire based expert judgement historic data latter bocr ahp strategic hierarchy via real time data collected defect consolidation log data sets linguistic variables proposed authors previous work thus propose investigate prototype dependability model inputs arising expert judgement real time data importantly proposed model realized without constructing actual working model analytical model based inputs past experience model replacement working model smaller medium projects additional inputs strengthen working model larger complex software systems thus paper proposes holistic model assess prototype dependability software prototype level early software life cycle process carried case study examine proposed approach evaluate economic feasibility projects industry
recent years global photovoltaic market expanded rapidly due sharp decline prices increased attention importance sustainable energy northern chile one highest irradiance levels world well one highest electricity rates latin america conditions chile one countries several projects developed without government subsidies consequently industry experiencing rapid growth paper reviews opportunity take advantage market conditions within residential sector modeling arrays across cities chile detailed modeling systems performed achieve accurate analysis energy production electricity cost using local resource data optimal array orientation inclination production losses review net metering net billing affect value production applied comparison using levelized cost electricity lcoe conducted net metering found better policy choice promote systems net billing energy injected electrical network paid complete retail rate however developed countries kind policy unlikely supported economic unfeasibility net billing scheme consumer see advantage energy recorded longer time intervals installing system smaller capacity relative household electricity consumption prevents excess generation injected network would bought utility lower prices retail rate payback periods found low years northern areas high retail rates years areas lower radiation retail rates published elsevier ltd
paper propose nonlinear tensor analysis methods tensor self organizing map tsom tensor generative topographic mapping tgtm tsom straightforward extension self organizing map high dimensional data tensorial data tgtm extension generative topographic map provides theoretical background tsom using probabilistic generative model methods useful tools analyzing visualizing tensorial data especially multimodal relational data given mode relational data tsom tgtm simultaneously organize set topographic maps furthermore used explore tensorial data space interactively visualizing relationships modes present tsom algorithm theoretical description viewpoint tgtm various tsom variations visualization techniques also described along applications real relational datasets additionally attempt build comprehensive description tsom family adapting various data structures elsevier ltd rights reserved
objectives sought investigate incidence atrial fibrillation catheter ablation typical atrial flutter determine predictors symptomatic atrial fibrillation required additional dedicated ablation procedure design patients underwent elective cavotricuspid isthmus ablation indication symptomatic typical atrial flutter occurrence atrial flutter atrial fibrillation cerebrovascular events need additional ablation procedures symptomatic atrial fibrillation assessed long term follow results majority patients manifested atrial fibrillation follow period months significant proportion underwent one multiple atrial fibrillation ablation procedures average months index procedure recurrence typical atrial flutter rare ten patients suffered cerebrovascular events earlier documentation atrial fibrillation previous use flecainide left atrial diameter independently predicted occurrence atrial fibrillation follow combination pre intra procedural documentation atrial fibrillation previous use flecainide independently predicted additional atrial fibrillation ablation discussion atrial fibrillation occurred majority patients ablation typical atrial flutter required additional dedicated ablation procedure pre intra procedural documentation atrial fibrillation together previous use flecainide independently predicted atrial fibrillation occurrence need additional ablation anticoagulation treatment continued high risk patients spite clinical disappearance atrial flutter
background purposewhen evaluating skin care products human skin quantitative test methods need simple precise reliable optical coherence tomography oct provides high resolution sectional images translucent materials depth millimeters technique usually applied medical measurements ophthalmology dermatology study aimed demonstrate application oct main technique monitoring changes skin topography tests wrinkle reduction product humans methodswe used commercial oct apparatus perform clinical examinations skin roughness treated non treated sites periorbital region thirty human voluntaries using anti aging product commercially available natura chronos flavonoides passiflora fps natura cosmeticos brazil measurements performed days treatment equipment software allowed real time recording skin roughness parameters wrinkle depths resultsthe oct measurements allowed monitoring changes skin roughness shown reduction treated sites around obtained depth distributions also indicate reduction occurrence wrinkles deeper verified results consistent typically obtained successful treatment modern anti aging products conclusionby using oct technique possible quantify changes skin roughness distribution depths skin wrinkles adequate sensitivity oct imaging allows direct visualization skin topography resolution micrometers reliable interactive tool clinical use therefore first time demonstrated use oct technique verify efficacy cosmetic products real time
study non darcian flow partially penetrating pumping well leaky aquifer investigated aquifer system composed main aquifer aquitard bounded top aquifer storage aquitard considered study main contribution study horizontal flow main aquifer assumed non darcian vertical flows main aquifer aquitard assumed darcian due relative low velocities non darcian flow described izbash equation linearization procedure associated laplace transform separate variable method used solve non darcian flow model semianalytical solutions laplace domain solutions obtained inverted time domain using stehfest method results indicated power index izbash equation results smaller drawdown late times flow approaches quasi steady state earlier leakage little impact drawdowns main aquifer larger drawdowns quite different different positions even radial distance sensitivity analysis indicated drawdown main aquifer sensitive power index moderately sensitive parameters main aquifer relatively sensitive parameters aquitard american society civil engineers
methyl aspartate nmda receptors fundamental normal function central nervous system cns play important role memory learning activation receptors leads neuronal loss associated major neurological disorders parkinson disease alzheimer disease schizophrenia epilepsy study novel enantiopure bicyclic lactams designed synthesized evaluated nmda receptor antagonists new compounds displayed nmda receptor antagonism promising compound showed value order magnitude memantine nmda receptor antagonist clinical use treatment alzheimer disease biological evaluation indicated compound brain permeable determined invitro assay non hepatotoxic results indicate chlorophenyl hydroxybenzyl tetrahydropyrrolo oxazol one compound potential candidate treatment pathologies associated activation nmda receptors
background aim study compare radiotherapy plans stage nasal natural killer cell lymphoma nnktl using helical tomotherapy volumetric modulated arc therapy vmat fixed field intensity modulated radiotherapy imrt three dimensional conformal radiotherapy crt methods eight patents stage nnktl treated imrt planned vmat two full arcs crt quality target coverage exposure normal tissue efficiency radiation delivery analyzed results showed significant improvement imrt terms cold spot volume homogeneity index planning target volume ptv vmat provided best dose uniformity ptv best dose homogeneity among four radiotherapy techniques ptv vmat obviously reduced treatment time compared imrt mean dose left right optic nerve significantly reduced imrt compared vmat maximum dose left lens vmat increased imrt conclusion unexpected results show vmat achieve higher conformal treatment plans getting worse organs risk oars sparing imrt patients stage nnktl vmat requires shortest delivery time imrt delivers lowest dose oars results could provide guidance selecting proper radiation technologies different cases
study compared subjective fracture risks hungarian women osteoporosis frax based estimates patients previous fracture parental hip fracture low femoral score higher age higher bmi likely underestimate risks patients also failed associate risk factors increased risk fractures purpose main objectives explore associations self perceived year fracture risks women osteoporosis risks calculated frax algorithm identify determinants underestimation risk methods carried cross sectional study centers hungary collected data risk factors considered frax calculator patients estimated subjective year probability major osteoporotic hip fracture numerically percentages also visual analog scale vas compared subjective frax estimates applied logistic regression analyze determinants underestimation risk associations risk factors subjective risk explored using linear probability models results nine hundred seventy two patients included analysis major hip fracture risk frax average subjective estimates significantly higher respectively correlations frax subjective measures weak underestimation major fracture risk associated single previous fracture parental hip fracture femoral score higher age body mass index better general health state find significant associations subjective risk estimates risk factors except previous fractures conclusions hungarian patients fail recognize risk factors fractures thus education patients risk factors would beneficial especially elderly low femoral score parental hip fracture history
today various science gateways created close collaboration scientific communities provide access remote distributed hpc grid cloud computing resources large scale storage facilities however observed still many entry barriers new users various limitations active scientists paper present latest achievements software solutions significantly simplify use large scale distributed computing describe several science gateways successfully created help application tools qcg quality cloud grid middleware particular vine toolkit qcg portal qcg make use hpc grid cloud straightforward transparent additionally share best practices lessons learned creating jointly user communities many domain specific science gateways dedicated physicists medical scientists chemists engineers external communities performing multi scale simulations deployed software solutions reached recently critical mass active users plgrid infrastructure poland also discuss paper changing technologies visual design user experience could impact way design science getaways even develop new attractive tools desktop mobile based applications future finally present information statistics regarding behaviour users help readers understand new capabilities functionalities may influence growth user interest science gateways hpc technologies
introduction emergency contraception offers women important strategy prevent unintended pregnancy following intercourse despite constant improvement availability different molecules techniques already existing yuzpe regimen levonorgestrel intrauterine device emergence ulipristal acetate numbers unintended pregnancies unplanned births could still reduced areas covered review evaluate information potential adverse effects tolerability method putting balance safety effectiveness literature search december performed identify trials studying safety data available concerning expert opinion different means demonstrated generally safe well tolerated data support women information order improve use efficacy
investigation paper dimensional gross pitaevskii equation time varying trapping potential describes dynamics dimensional bose einstein condensate employing hirota method symbolic computation obtain dark one soliton two soliton three soliton breather wave rouge wave solutions respectively graphically study dark solitons time varying harmonic potential scaled scattering length parallel period solitons observed obtain external trapping potential increases time amplitudes dark solitons increase widths solitons become narrower external trapping potential periodic function amplitudes widths dark solitons periodically change decrease scaled scattering length leads narrower solitons widths affect solitons amplitudes breather waves rouge waves also displayed rouge waves emerge period breather waves infinity
conventional hinge designs planar compliant mechanisms limited deformation range high stresses induced deflection improve range motion mechanisms hinges allow large displacement highly desirable paper explores use curved beams large displacement hinges planar compliant mechanisms facilitate design analytic expressions predict deflections different types loads introduced expressions used pseudo rigid link models compliant mechanism designs predictions made analytic expressions compared results fea simulations validate proposed models two planar compliant mechanism designs prepared experimental measurements deflections loads made overall results showed analytic models fea predictions lie within experimental data planar mechanism geometry pseudo rigid motion models apply fea models second case complex mechanism make predictions lie within experimental measurements results ways improve accuracy models designs discussed end article elsevier inc rights reserved
majority farmers india irrigating crops without using irrigation scheduling criteria consequently application excess irrigation water causes water logging wastage precious water resources plant diseases soil salinity well lack water results crop water stress present research work automated wireless gypsum block sensor network system wsn developed automate irrigation scheduling developed gypsum blocks sensors interlinked global system mobile gsm module microcontroller unit sensor performed well range volumetric moisture content sensors reliable range kpa sensors highly correlated coefficient determination slope small relative root mean square error rrmse given soil moisture potential depth microcontroller starts pump soil moisture content reaches field capacity stops field reaches given threshold rage field information received user mobile via transmitters receiver using text messages system saves water average
dynamic development internal combustion engines creates need adopt strategy concerning operational use driving units based knowledge technical condition assessment technical condition belongs tasks technical diagnostics article presents analysis issues concerning vibration diagnostics automatic compensators clearances piston valves combustion engine scientific experiments focused delivering information necessary create also validate diagnostic models enabling assessment technical condition elements combustion engine essential taking account effectiveness durability carried described basis worked diagnostic model algorithm assessment technical condition automatic compensators valve clearance created elsevier ltd rights reserved
objective overview evaluate main findings methodological shortcomings time trends recent psychiatric epidemiology studies turkey well provide areas prone development forthcoming research method pub med turkish psychiatry index screened identify relevant studies epidemiological study general population unique sub population sample included papers results classified depression anxiety psychotic dissociative conversion personality alcohol substance abuse trauma related disorders common geriatric disorders results various epidemiological studies various psychiatric disorders turkey however main shortcomings trends research subsequently stagnate current psychiatric epidemiological research first epidemiological studies mainly conducted academic purposes addressing epidemiological issues issues health policy second studies mainly focused particular fields institutions led non systematic accumulation epidemiological results third although turkey natural laboratory social conflicts disasters studies focus probable outcomes fourth high quality epidemiological studies disseminating results tended decrease even common mental disorders depression fifth epidemiological studies using contemporary designs follow genetic biomarker data general population conclusion although psychiatric epidemiological studies last decade provide suitable ground future challenges current trends research area tended stagnate despite potential unique contributions forthcoming studies researchers may notice novel methodological developments epidemiology growing attention rapid urbanization natural disasters social conflicts migration
decreasing air pollution concentrations internal combustion engine ice especially agricultural machines transporters interested current treatment methods many disadvantages low treatment efficiency high cost complex operation therefore study gas pollution treatment model ice using cold plasma designed manufactured solve problems maha emission testers diesel gasoline center motor vehicle registration hcm city used results evaluation results show treatment efficiency nox respectively model portable xxmm plugin
background basophil activation tests bats promise research clinical monitoring patients allergies however bat protocols vary blood anticoagulant used temperature time storage testing complicating comparisons results various studies objective attempted establish bat protocol would permit analysis blood within hours obtaining sample methods blood healthy donors patients peanut allergy collected edta heparin tubes samples stored degrees room temperature hours performing bats results stimulation anti ige resulted strong upregulation basophil cdc samples collected edta heparin stored degrees analyzed hours sample collection however population basophils observed conditions edta treated samples unless exogenous calcium magnesium added time antiige stimulation contrast blood samples collected heparin tubes adequate quantification upregulation basophil cdc identification population basophils irrespective whether specimens analyzed means conventional flow cytometry cytometry time flight mass spectrometry tests could performed blood stored hours degrees conclusion bats measure upregulation basophil cdc induction basophil population conducted blood obtained heparin tubes stored degrees hours
cancer survivors often experience poor post treatment musculoskeletal health study examined feasibility combined aerobic resistant training cart improving strength skeletal health balance cancer survivors identified convenience sampling los angeles county survivors consenting weeks cart pre post intervention assessments bone mineral density bmd strength flexibility biomarker analysis performed paired test analysis suggested increases lower upper body strength average score bmd femoral neck improved whole body bmd improved baseline follow participants also displayed decreases sway velocity eyes open eyes closed conditions improvement lower body strength associated increases lean body mass lbm inverse association observed sway velocity lbm age time since last treatment related biomarkers anabolic growth igf igfbp bone dpd bap summary observed physiological changes consistent functional improvements suggesting isometric dynamic exercise prescription may reduce risk falls fall related fractures among survivors
propose quantum secret sharing scheme uses orthogonal pair qudit ghz states local distinguishability proposed protocol participants use basis measurement classical communication distinguish two orthogonal states reconstruct original secret also present threshold generalized restricted threshold schemes enable two cooperating players two disjoint groups always reconstruct secret compared existing scheme rahaman parker phys rev proposed scheme general access structure contains authorized sets
document describes development methodology analysis variables water sources particularly river bogota order evaluate test predict rate water pollution proposed raised necessary aspects processing data extracted database car review previous work importance determining measured indices water quality proposed work scope done approach important variables considered research according procedures standard data analysis
parentage data beef calves shown multiple sire pastures disproportionate number calves born single bull investigating accurately quantifying bull behavior within multiple sire pastures begin determine reason variability number calves sired study objective assess accelerometer data various classification algorithms accurately predict bull behavior events multiple sire pasture behavior events interest study included lying standing walking mounting two bulls ten estrous synchronized cows used true behavior events determined daylight hours video analysis matched accelerometer data accelerometers attached ears withers neck bulls accelerometer data recorded every second days accelerometer data used generate algorithms accuracy evaluated compared known video behavioral data prevalence based raw video data lying standing walking mounting random forest classifier highest accuracy compared classifiers random tree decision tree tag location behavior interest accuracies random forest algorithms ranged lying standing walking mounting classification algorithm able accurately predict lying standing event predict walking mounting event lower accuracy research needed determine behaviors bulls affects overall parentage data elsevier rights reserved
multifunctional catalyst electrode mimicking external stimuli responsive property prepared situ growth nitrogen doped nife double layered hydroxide nife ldh nanolayers nickel foam substrate framework electrode demonstrates superior performance toward catalyzing oxygen evolution reaction oer affording low overpotential current density high faradaic efficiency approximate stable operation meanwhile electrode dynamically change color gray silver dark black oer happening coloration bleaching processes persist least cycles rendering useful tool monitor catalytic process mechanism study reveals excellent structural properties electrode conductive framework ultra thickness nife ldh nanolayer approximate high doping content approximate make significant contribution achieving enhanced catalytic performance nife ldh nanolayer electrode main contributor stimuli responsive property reversible extraction insertion electrons nife ldh leading coloration bleaching processes potential application electrode demonstrated integrating air battery device identify charging process electrochemical cycling
background anaplastic thyroid carcinoma atc rare tumor poorly defined oncogenic molecular mechanisms limited therapeutic options contributing poor prognosis aims retrospective study determine frequency anaplastic lymphoma kinase alk translocations identify mutational profile atc including tert promoter mutations methods materials one hundred forty four atc cases collected centers part national french network management refractory thyroid tumors fluorescence situ hybridization analysis alk rearrangement performed tissue microarrays panel genes using next generation sequencing tert promoter mutations using sanger sequencing also screened results fluorescence situ hybridization interpretable cases one case positive alk rearrangement borderline threshold positive cells next generation sequencing results interpretable cases sanger sequencing tert cases total mutations intronic exonic identified alterations frequent forty three percent harbored mutation ras genes mutation braf gene essentially pik akt pathway mutation ras pik pathway mutations pten mutations nearly cases showed mutations ras pik akt pathways mutations alk atm apc cdkna erbb ret smad including mutations yet described thyroid tumors genes encoding potentially druggable targets included mutations atm gene four cases erbb one case met one case alk one case tert promoter alteration found cases including mutations three cases harbor mutations panel genes therapeutic interest conclusion study confirms alk rearrangements atc rare mutational landscape atc heterogeneous many genes implicated follicular epithelial cell dedifferentiation process may explain limited effectiveness targeted therapeutic options tested far
background use electronic health records ehrs dental care effect dental care provider patient interaction studied sufficiently authors conducted study explore dental care providers interactions ehrs patient visits interactions influence dental care provider patient communication providers patients perception ehr use dental clinic setting patient visits methods authors collected survey interview data patients providers three dental clinics health care system authors used qualitative quantitative methods analyze data obtained patients dental care providers results provider survey results showed significant differences perceptions ehr use patient visits across dental care provider groups dentists dental hygienists dental assistants patient survey results indicated patients experienced certain level frustration distraction providers use ehrs visit conclusions provider survey results indicated different perceptions across provider groups ehrs effect computer use communication patients dental assistants generally reported negative effects communication patients owing computer use interview results also indicated dental care providers may feel comfortable interacting ehr without verbal eye contact patients patient dental visit practical implications new design dental operatories locations computer screens within operatories undertaken prevent negative nonverbal communication loss eye contact forcing provider patient sit back back well enhance patient education information sharing
issue testability intended measure solvability parametric fault diagnosis problem analog linear time invariant electrical networks addressed paper independently considered fault location method important metric provides information many components diagnosed reader convenience set appropriate framework main achievements first concern rederive fundamental results concerning analog linear time invariant electrical network testability hinging multifrequency measurements novel algorithm testability analysis proposed straightforward able circumvent main drawbacks formerly proposed methods computational conceptual complexities proneness roundoff errors vulnerability particular cases computer program implements algorithm also described moreover possibility employing simplified versions latter links previously proposed approach discussed rigorous bases finally examples provided show effectiveness robustness new algorithms also means comparison old ones copyright john wiley sons ltd
background many patients emotional stress may exacerbate acne psychological problems social phobias low self esteem depression may also occur result acne presence acne may negative effect quality life self esteem mood affected patients studies undertaken anxiety depression personality patterns patients acne studies done identify specific personality disorders patients acne furthermore dearth data regarding effect personality disorder psychological states patients prompted undertake present study methodology descriptive cross sectional study undertaken tertiary care teaching hospital eastern india consecutive patients suffering severe grade acne attending dermatology outpatient department aged years included study results total patients evaluated mean age years personality disorder present patients diagnosed personality disorders obsessive compulsive personality disorder anxious avoidant personality disorder borderline personality disorder mixed personality disorder patients personality disorder psychiatric comorbidity patients personality disorder higher number anxiety depressive disorders also statistically significant conclusion present study highlights personality disorders psychiatric comorbidities common setting severe acne
verticillium dahliae economically relevant soilborne pathogen causes vascular wilt several crops including pepper capsicum annuum fungal infection usually visualized vascular browning likely due onset phenylpropanoid metabolism also seems play crucial role tolerance pepper varieties current work potential function distinct phenylpropanoid derivatives suberin lignin phenolic compounds pepper tolerance response dahliae investigated histochemical biochemical analyses ruled suberin key player pepper fungus interaction however changes observed lignin composition higher deposition bound phenolics infected stems seemed contribute reinforcement cell walls impairment dahliae colonization importantly first time accumulation hydroxycinnamic acid amide feruloyltyramine reported pepper stems response vascular fungus fungitoxic activity hydroxycinnamate tyramine conjugate demonstrated well elsevier rights reserved
vision declines normal aging alzheimer disease although toxic role amyloid beta established pathogenesis influence aging retina unclear using app swe delta transgenic mice classical model retinal cell function survival assessed electroretinogram erg recordings immunofluorescent stainings strikingly photopic erg measurements revealed retinal response mediated cones preserved aging mice relative controls contrast cortex expression mutated app swe delta allow detect amyloid plaques month old male retinae addition ctf beta ctf alpha ratio significantly lower retinal samples cortical extracts suggesting non amyloidogenic pathway may endogenously limit formation retina male mice collectively data suggest retinal specific processing amyloid may confer protection selectively preserve cone dependent vision aging elsevier inc rights reserved
paper seeks investigate postporgraphic production colombian artist nadia granados character fulminante explores exploits stereotypical representation sexually provocative latino women order generate libertarian artisticinterventions public space performances powerful critics normative gender roles also violence female bodies time work allows think possibility recovering autonomy feminized bodies pleasure sexuality theoretical contributions use analyze work colombian artist studies performance decolonial feminism finally important inscribe granados work part history feminist art performing arts explored women artists visualize violence passes bodies also possibility leakage resistance terms gender sexualities
article analyzes governance health regions contributions two studies one governance model duties management public policies networks former conducted meta analysis case studies literature collaborative governance aimed preparing explanatory analytical model authors identified critical variables influence results previous history conflict cooperation incentives participation power imbalances leadership institutional design also identified key factors face face dialogue trust building development commitment shared vision latter study examined networks public policies analytic tradition perspective governance incorporating concepts field political science economics interorganizational relations order support management public policies networks study identified network management equivalent strategic game involving functions network activation framework relations intermediation facilitation consensus building mediation arbitration combination two reflections provides conceptual reference better understanding governance health regions
objectives injuries responsible global burden disease however epidemiology injury among people living hiv plhiv well elucidated study seeks characterize rates predictors injury among plhiv compared general population british columbia canada design population based dataset created via linkage centre excellence hiv aids populationdatabc methods plhiv aged years older compared random sample adult general population international classification diseases codes used classify unintentional intentional injuries based external cause injury generalized estimating equation gee poisson regression models fit estimate effect hiv status rates unintentional intentional injury identify correlates injury among plhiv results crude incidence rate unintentional injury person years confidence interval among plhiv person years general population among plhiv deaths due injury compared deaths general population adjusted models plhiv likely report unintentional incidence rate ratio intentional injury incidence rate ratio compared general population conclusions identified elevated rates intentional unintentional injury among plhiv injuries largely preventable targeted efforts needed decrease burden injury related disability death among plhiv copyright wolters kluwer health inc rights reserved
sandfish lizard scincus scincus squamata scincidae spends nearly whole life aeolian sand comes surface foraging defecating mating yet understood animal respire without sand particles entering respiratory organs buried thick layers sand work integrated biological studies computational calculations physical experiments understand phenomenon present model upper respiratory system based detailed histological analysis printed version model used combination characteristic ventilation patterns computational calculations fluid mechanics experiments calculating velocity field identified sharp decrease velocity anterior part nasal cavity mucus cilia present experiments printed model validate calculations particles present found area suggested calculations postulate sandfish aerodynamic filtering system specifically characteristic morphology respiratory channel coupled specific ventilation patterns prevent particles entering lungs
isotropic homogeneous cosmological model source dark energy studied source simulatedwith viscous relativistic fluidwith minimal causal correction model restrictions parameters coming following conditions analized energy density without singularities along time scale factor increasing time universe accelerated present time state equation dark energy omega bounded close found conditions satisfied following two cases transport coefficient tau associated causal correction negative additional restriction zeta tau relativistic bulk viscosity coefficient state equation phantom energy sector tau positive essence sector performed exact calculation case equation state constant finding option favored relation entropy always increasing happen
paper presents distributed computing architecture solving distribution optimal power flow dopf model based smart grid communication middleware sgcm system system modeled unbalanced three phase distribution system includes different kind loads various components distribution systems paper fixed loads modeled constant impedance current power loads neural network models controllable smart loads integrated dopf model genetic algorithm used determine optimal solutions controllable devices particular load tap changers switched capacitors smart loads context energy management system practical feeders accounting fact smart loads consumption significantly affected network constraints since number control variables realistic distribution power system large solving dopf real time applications computationally expensive hence reduce computational times decentralized system parallel computing nodes based sgcm system proposed using mapreduce model sgcm system runs dopf model communicates master worker computing nodes sends receives data among different parts parallel computing system compared centralized approach proposed architecture shown yield better optimal solutions terms reducing energy losses energy drawn substation within adequate practical run times realistic test feeder
debates whether rainwater suitable drinking water serious shortcoming debate differences design management rainwater harvesting rwh systems study based performance two rwh systems used drinking purposes kindergarten primary school khe vietnam system comprised painted galvanized iron roof first flush diverter two stainless steel tanks connected series calmed inlet mosquito screens open holes pvc pipelines filter cartridges sterilizer months stored rainwater sampled five times treated rainwater sampled four times twenty three water quality parameters analyzed including total dissolved solids turbidity nitrate nitrite ammonia hardness arsenic iron cadmium nickel chromium manganese mercury selenium lead zinc escherichia coli total coliform found physicochemical qualities stored rainwater prior treatment satisfied world health organization drinking water guidelines physical filtration sterilization parameters including microbiological indicators satisfied drinking water guidelines management strategies stabilize water quality discussed
objective weight restoration anorexia nervosa associated lower relapse risk however rate weight gain percent patients achieving weight restoration bmi discharge vary among treatment programs compared cost pound weight gained cost weight restoration hospital based inpatient partial hospitalization eating disorders program estimates costs residential treatment method adult first admissions program included cost care based hospital charges rates weight gain weight restoration data results compared residential treatment costs extracted national insurance claims database published weight gain data results average charge day program yielding average cost pound gained respectively patients achieving weight restoration based published mean weight gain data conservative cost day estimates residential treatment associated higher cost pound higher cost lower likelihood weight restoration patients discussion key metrics used study recommended comparing costeffectiveness intensive treatment programs patients
purpose purpose paper present impulsive lifestyle counseling ilc program time limited psychoeducational approach increasing patient awareness antisocial personality disorder aspd consequences design methodology approach paper describes ilc program program developed add treatment substance use disorders suds gives examples issues patient counselor interactions ilc sessions findings ilc sessions patients engaged counselors diverse ways reflecting varying levels psychopathology overall functioning barriers incentive lifestyle changes originality value patients sud comorbid aspd receive better care brief counseling focusses antisocial behavior thinking diverse evidence based treatments needed disorder
entropic surfaces represented fluctuating two dimensional membranes predicted desirable mechanical properties unstressed including negative poisson ratio auxetic behavior herein present calculations strain dependent poisson ratio self avoiding membranes demonstrating desirable auxetic properties range mechanical strain finite size membranes unclamped boundary conditions positive poisson ratio due spontaneous non zero mean curvature suppressed explicit bending rigidity agreement prior findings applying longitudinal strain along singular axis system suppresses mean curvature entropic plane fluctuations resulting molecular scale mechanism realizing negative poisson ratio critical strain values significantly negative previously observed zero strain limit infinite sheets find auxetic behavior persists surprisingly high strains smallest surfaces desirable finite size scaling producing surfaces negative poisson ratio wide range strains results promise design surfaces composite materials tunable poisson ratio prestressing platelet inclusions controlling surface rigidity matrix materials
kidscreen developed part cross cultural european union funded project standardise measurement children health related quality life yet research reported mixed evidence hypothesised factor model confirmatory factor analysis cfa conducted instrument children low socio economic status ses across ireland northern republic data study collected part clustered randomised controlled trial total male female year old children low ses took part modified factor cfa models specified using maximum likelihood estimation nested chi square difference test conducted compare fit models internal consistency floor ceiling effects also examined cfa found hypothesised factor model unacceptable fit however modified factor model supported nested chi square difference test confirmed fit factor model significantly better factor model internal consistency unacceptable one scale ceiling effects present one factors future research apply factor model children low socio economic status efforts would help monitor health status population
constructed markov microsimulation model among hypothetical cohorts community dwelling elderly osteoporotic japanese women without prior hip vertebral fractures lifetime horizon compared weekly oral alendronate years denosumab every months years cost saving cost effective conventionally accepted threshold objective study examine cost effectiveness subcutaneous denosumab every months years compared weekly oral alendronate years japan calculated incremental cost effectiveness ratios icers dollars per quality adjusted life year qaly using markov microsimulation model among hypothetical cohorts community dwelling osteoporotic japanese women without prior hip vertebral fractures various ages therapy initiation years lifetime horizon three perspectives societal healthcare sector government denosumab cost saving compared alendronate ages years three perspectives icers denosumab compared alendronate per qaly ages years societal perspective exceed willingness pay per qaly two perspectives deterministic sensitivity analyses results sensitive changes effectiveness denosumab reducing hip fracture clinical vertebral fracture rate ratio non persistence denosumab compared alendronate probabilistic sensitivity analyses probabilities denosumab cost effective compared alendronate willingness pay per qaly among community dwelling elderly osteoporotic women japan denosumab every months years cost saving cost effective conventionally accepted threshold willingness pay ages examined compared weekly alendronate years study provides insight clinicians policymakers regarding relative economic value osteoporosis treatments elderly women
background addictions psychoactive substances tobacco others widely investigated recently interest developing potential nonsubstance addictive behaviors gambling buying playing video games methodology current study sought develop questionnaire obtained yale addictive food questionnaire arabic version compare gold standard tool semi structured icd diagnostic based interview also sought determine prevalence addictive behaviors sample participants displaying addictive behaviors drawn governorates egypt cairo aswan null hypothesis postulated difference within sociodemographic variables regard type nonchemical addictive behaviors results questionnaire sensitivity plausible specificity making good screening tool participants showed addiction like attitude toward concerning behaviors conclusions besides usual psychoactive substance dependence wide ranges behaviors cause lot psychological burden unfortunately spotlight medical services
gallbladder adenomyomatosis benign alteration gallbladder wall found patients characterized gallbladder wall thickening containing small bile filled cystic spaces rokitansky aschoff sinuses ras bile contained ras may undergo progressive concentration process leading crystal precipitation calcification development correct characterization fundamental order avoid unnecessary cholecystectomies ultrasound imaging modality choice diagnosing use high frequency probes precise focal depth adjustment enable correct identification characterization majority cases contrast enhanced ultrasound ceus performed ras clearly identified baseline ras appear avascular ceus independently content magnetic resonance imaging mri reserved cases unclear ceus mri ras identified extremely high sensitivity signal intensity varies widely according content positron emission tomography pet may helpful excluding malignancy selected cases computed tomography cholangiography routinely indicated suspicion teaching points gallbladder adenomyomatosis common benign lesion patients identification rokitansky aschoff sinuses crucial diagnosing gallbladder adenomyomatosis sonography imaging modality choice diagnosing gallbladder adenomyomatosis intravenous contrast material administration increases ultrasound accuracy diagnosing gallbladder adenomyomatosis magnetic resonance problem solving technique unclear cases
conventional integer order proportional integral derivative iopid workhorse control almost industrial processes due structural simplicity application fractional calculus field control engineering fractional order pid controllers gaining popularity since requires slight modification integer order pid controller tuning integer order pid controller parameters well known techniques like ziegler nichols method cohen coon method etc mostly time domain based frequency techniques also available present research work attempt made tune fopi controller using frequency domain specifications frequency domain specifications considered design includes phase margin specification gain crossover frequency specification robustness gain variations proposed control schemes applied three interacting tank process represented third order system verified servo regulatory servo regulatory response robustness conditions comparison time domain performance indices performed guarantee superiority proposed scheme
three studies compared beliefs natural late blooming positive traits acquired personal effort extrinsic rewards medicine young children years older children years adults showed strong bias natural late blooming traits acquired traits age groups except year olds treated natural late blooming traits fixed essences would persist time challenging conditions older children adults viewed traits acquired intrinsic effort similar natural late blooming traits acquired bribes medicine suggesting intrinsic effort comes seen natural mechanism change bias natural may therefore early emerging way evaluating others reinforced ambient culture becomes stronger increasing age
presence congenitally impaired skin barrier followed atopic dermatitis initial step atopic march maintenance acidic stratum corneum suggested therapeutic preventive strategy barrier impairment caused skin inflammation determine whether murine model flaky tail mice inherited filaggrin deficiency could develop airway inflammation repeated topical application followed nasal inhalation house dust mite hdm antigen defined novel atopic march animal model whether maintenance acidic environment continuous application acidic cream could interrupt following atopic march course hdm treatment acidic cream neutral cream applied flaky tail mice twice daily repeated applications inhalations hdm flaky tail mice induced skin lesions followed respiratory allergies maintenance acidity inhibited occurrence respiratory allergic inflammation well like skin lesions collectively novel atopic march model could developed repeated epicutaneous nasal applications hdm flaky tail mice acidification could prevent atopic march respiratory allergy
result development internet ict information centric technology advances including mobile cloud social networking big data multimedia tendency towards digital society management configuration become highly complex challenging time consuming also access high bandwidth extendibility dynamic management critical significance especially network devices vertically integrated hence set unique predefined line commands operating systems firmware used sdn software defined networking structure designed simplifying improving network management high flexibility splitting control plane data plane thus network programmability enhanced turn leads innovation opportunities although sdn regarded new research issue attracted numerous researchers attention industrial academic institutes paper data plane control plane application plane three planes sdn interfaces openflow investigated challenges latest technologies relation sdn examined investigation overview sdn reported paper might used interested future researchers better understand apply sdn real life applications elsevier ltd rights reserved
introductory information non synaptic transmission sympathetic neuroeffector junctions sympathetic nerve cotransmission utilizing noradrenaline atp cotransmitters organzation location sympathetic nerves different sites kidney described including renal arteries juxtaglomerular arterioles renal tubules sympathetic nervous control glomerular filtration rate renin secretion discussed evidence obtained largely experiments animals sympathetic nerve modulation transport water sodium ions collecting duct nephron described finally coverage roles sympathetic nerves renal diseases including hypertension diabetes hypothyroidism ischaemia elsevier rights reserved
study association among different sources individual differences personality cognitive ability risk attitudes trust reciprocate behavior incentivized experimental binary trust game sample females undergraduate students game involves two players player player first stage decides whether trust let decide secure egalitarian payoff players trusts latter choose symmetric payoff double secure alternative discarded asymmetric payoff earns case makes worse main experiment obtained participants scores abstract reasoning risk attitudes basic personality characteristics specific traits psychopathy impulsivity main experiment measured heart rate electrodermal activity eda variation account emotional arousal caused decision feedback processes main findings indicate one hand trust behavior associates positive emotionality specifically extraversions warmth facet addition impulsivity facet positive urgency also favors trust behavior relation trusting behavior found either major personality aspects risk attitudes physiological results show participants scoring high psychopathy exhibit increased eda reduced evoked deceleration moment asked decide whether trust regarding find ability mainly low disagreeable disinhibition favor reciprocal behavior specifically lack reciprocity significantly relates psychopathic highly disinhibited impulsive personality thus present study suggests personality characteristics would play significant role different behaviors underlying cooperation extraversion positive emotionality relevant initiating cooperation low disagreeable disinhibition maintaining
damages asphalt pavement usually observed traffic volume traffic load excessive least two methods improve performance asphalt pavement first method modify asphalt cement polymer additive second method reinforce asphalt pavement geosynthetic reinforcement combined effects two methods interest study series physical models asphalt pavement structure performed investigate behaviours geosynthetic reinforced asphalt pavements two types pavements prepared modelling new pavement repaired pavement overlay pavement normal asphalt cement polymer modified asphalt cement used two types geosynthetic reinforcements geogrid apertures geocomposite geogrid plus geotextile without aperture used reinforce asphalt pavement layer uniform dense sand layer used preparation foundation soil supporting pavement sand box pavements vertically loaded footing photogrammetric analysis performed determine strain field mobilised sand layer found pavement surface settlement decreased maximum shear strain less localised reinforcing effects distortional permanent deformation asphalt decreased improvement asphalt cement used iii geogrid preferable installed inside asphalt aperture would beneficial interlocking geocomposite appropriate installed bottom asphalt pavement elsevier ltd rights reserved
objective evaluate effectiveness safety insulin detemir treatment add therapy real world setting lebanese insulin naive persons type diabetes poorly controlled oral antidiabetic drugs oads methods study prospective observational study representing lebanese arm multinational prospective observational study involving persons across near east countries lebanon pakistan israel jordan effectiveness endpoints changes hbac fasting post prandial glucose fpg ppg weeks treatment insulin detemir eligible persons safety endpoints number hypoglycemic events incidence adverse drug reactions adrs serious adrs adverse events body weight change baseline end treatment results persons included mean age years men glycemic control improved significant reduction mean hbac percentage persons achieved target hbac increased baseline week mean fpg decreased significantly mean ppg rate major hypoglycemic episodes decreased baseline week three adverse events adr serious adr reported body weight decreased conclusions initiating insulin detemir clinical health care setting among lebanese type diabetes mellitus oads improves glycemic control increase hypoglycemia adverse events weight compared baseline
allergic diseases rise western world well known allergy protecting driving factors microbial dietary exposure pollution smoking mediate influence alterations epigenetic landscape review key facts involvement epigenetic modifications allergic diseases summarize critically evaluate lessons learned epigenome wide association studies show potential epigenetic changes various clinical applications diagnostic tools assess tolerance following immunotherapy possibly predict success therapy early time point furthermore new technological advances epigenome editing dnazymes allow targeted alterations epigenome future provide novel therapeutic tools
recent years witnessed development visibility graph theory allows analyze time series perspective complex network paper develop novel time dependent limited penetrable visibility graph tdlpvg two examples using nonstationary time series intervals gas liquid flows provided demonstrate effectiveness approach results first example suggest tdlpvg method allows characterizing time varying behaviors classifying heart states healthy congestive heart failure atrial fibrillation interval time series second example infer tdlpvgs gas liquid flow signals interestingly find deviation node degree tdlpvgs enables effectively uncover time varying dynamical flow behaviors gas liquid slug bubble flow patterns results render tdlpvg method particularly powerful characterizing time varying features underlying realistic complex systems time series elsevier rights reserved
backgroundnd orthopaedic surgeons pivotal role transitioning care orthopedic patients biomedical biopsychosocial rrlodel effort foster transition designed study airried determine surgeonis attitudes practice noticing screening discussing osycholpgical illness patients well making referra address psychosocial issues patients need additionally vve asked surgeons rank order potential barriers reasons referrals psychosocial treatment methods orthopaedic surgeons members science variation group ankle platform completed demographics part survey assessing degree surgeons notice assess screen refer psychological treatments well ranked ordered barriers engaging processes results group surgeons neutral referral psychological treatment formal screening psychological factors somewhat likely notice discuss psychological factors surgeons likely refer psychological treatment engaged research reside south america opposed north america highest ranked barriers screening noticing discussing referring psychological treatment lack time stigma feeling uncomfortable conclusion overall surgeons likely notice discuss psychological factors less likely formally screen refer psychological treatment transition biopsychosocial models focus problem solving barriers teaching surgeons communication skills increase comfort discussing psychoemotional factors associated orthopedic problems use empathic communication helpful normalizing difficulty coping orthopedic condition may facilitate referral
diethylstilbestrol des synthetic estrogen given pregnant women prevent miscarriages preterm labor drug used united states countries des exposure associated significant long term health effects including increased risk breast cancer cervical vaginal clear cell adenocarcinoma reproductive tract abnormalities infertility poor pregnancy outcomes early menopause article reviews potential health risks associated des exposure assess patients risk management recommendations patients exposed des
fluorescence spectroscopy widely used study water pollution fluorescence water natural organic matter classified two groups protein like fluorescence originating aromatic amino acids humic fluorescence originating humic substances actually precise molecular origin protein like fluorescence unknown fluorescence may caused either free amino acids peptides proteins therefore studied molecular origin protein like fluorescence suwannee river natural organic matter fractions obtained size exclusion chromatography polyacrylamide gel electrophoresis fractions analyzed reversed phase high performance liquid chromatography electrophoretic mobilities fractions varied order molecular size opposite order results show protein like fluorescence almost exclusively located high molecular size fraction medium molecular size fraction retention times fluorescence emission spectra authentic free aromatic amino acids tyrosine tryptophan identical retention times emission spectra several chromatographic peaks fractions protein like fluorescence due free aromatic amino acids incorporated water natural organic matter
prior studies documented people general respond others narcissism existing research offers clues whether evaluator narcissism influences judgments traits associated narcissism participants completed narcissistic personality inventory evaluated hypothetical target persons target narcissism conveyed single trait description study list traits study facebook content study narcissistic qualities reliably viewed unfavorably narcissistic participants comparatively less bothered target narcissism less positive judgments targets without narcissistic qualities study symptoms presence absence narcissism less impact social judgments participants narcissistic
migraine headache associated symptoms plagued humans two millennia manifest throughout world affects global population common brain disorder characterized moderate severe unilateral headache accompanied vomiting nausea photophobia photophobia hypersensitive symptoms senses still dear lack understanding neurophysiology beginning understood seems suggest migraine disorder brain sensory processing characterized generalized neuronal hyperexcitability complex symptomatology migraine indicates multiple neuronal systems involved including brainstem diencephalic systems function abnormally resulting premonitory symptoms ultimately evolving affect dural trigeminovascular system pain phase migraine migraineur also seems particularly sensitive fluctuations homeostasis sleep feeding stress reflecting abnormality functioning brainstem diencephalic systems implications therapeutic development grown understanding migraine neurophysiology leading major drug classes triptans calcitonin gene related peptide receptor antagonists htif receptor agonists well neuromodulatory approaches promise come present review discuss current understanding neurophysiology migraine particularly migraine headache novel insights complex neural networks responsible associated neurological symptoms interaction networks migraine pain pathways implications development novel therapeutics elsevier inc rights reserved
study aimed establish norms modified chinese version autism spectrum rating scale asrs participants recruited shanghai harbin guangzhou changsha china parents teachers invited complete chinese parent version teacher version asrs versions boys significantly higher sub scale scores total score score points respectively girls age weak correlations sub scores score ranged reached significance correlations appeared stronger common females score based chinese norms ideally correlated score based united states norms boys girls versions norms chinese version asrs children aged years proposed may helpful screening individuals autism spectrum disorders general population children
next generation networking protocol openflow enhances network performance separating control plane data plane implemented quality service users desiring network resources higher priorities defined system allocated adequate resources besides communication protocol another two elements required complete openflowsystem switch either physical virtual supports openflow controller sends setting packets control switch flow table openflow users restricted functions provided specific switch since standard application programming interface api users define wanted functions instead predefined ones bundled operating systems paper aims create openflow switch monitoring system oversees traffic pass switches controller provides convenient webpage network administrators modify flow priorities effectively manage network
background hypothyroidism due non compliance levothyroxine therapy pseudomalabsorption rare diagnosis considered patients persistent severe hypothyroidism despite treatment large doses levothyroxine intestinal malabsorption drug dietary interference levothyroxine absorption nephrotic syndrome excluded diagnosis pseudomalabsorption demonstrated using oral levothyroxine test showing rapid decrease thyroid stimulating hormone increase thyroxine however data sensitivity specificity test large cohorts hypothyroid patients treatment pseudomalabsorption controversial reports using parenteral intramuscular single weekly oral dosing levothyroxine cases report patients presented persistent clinical biochemical signs hypothyroidism despite replacement therapy high doses levothyroxine pseudomalabsorption diagnosed systematic approach including prior exclusion digestive liver kidney diseases peroral challenge test positive cases patients denied non compliance psychiatric approach elusive two patients treated successfully single supervised weekly administration levothyroxine non supervised weekly administration resulted hypothyroidism confirming pseudomalabsorption conclusions non compliance medical therapy considered patients treatment refractory hypothyroidism supervised weekly levothyroxine treatment safe well tolerated treatment option obviating need parenteral administration drug apart medical treatment also need psychiatric evaluation care european thyroid association published karger basel
purpose study evaluate presence dentinal defects root canal preparation hand instruments two different reciprocating instruments sixty freshly extracted mandibular incisor teeth selected vitro study basis root length mesiodistal buccolingual dimensions teeth allocated three identical experimental groups one control group teeth control group left unprepared groups stainless steel hand instruments waveone primary instruments reciproc instruments reciprocating instruments used reciprocating gentle motion torque limited electric motor appropriate preset mode horizontal sections made apex samples stained methylene blue viewed stereomicroscope presence dentinal defects fractures incomplete cracks craze lines locations investigated two endodontists data analysed statistically fisher exact chi square tests defects observed unprepared group instruments caused dentinal defects significant differences instrument systems experimental groups demonstrated significantly defects level comparison unprepared group levels significant difference experimental groups control group use hand reciprocating instruments could induce formation dentinal defects root canal preparation
paper reviews compelling evidence disrupted circadian rhythms individuals mood disorders major depressive disorder seasonal affective disorder bipolar disorder treatments bright light designed alter circadian rhythms effective treating disorders neurotransmitters brain regions implicated mood regulation exhibit circadian rhythms mouse model originally employed identify circadian gene proven potent model mania evidence suggestive etiological role altered circadian rhythms mood disorders compatible explanations including disrupted circadian rhythms mood disorders effects common cause genes proteins implicated simply pleiotropic effects light paper advances proposal evidence would needed establish direct causal link disruption circadian rhythms mood disorders
paper suggests evolving possibilistic approach fuzzy modelling time varying processes approach based extension well known possibilistic fuzzy means fcm clustering functional fuzzy rule based modelling evolving possibilistic fuzzy modelling epfm employs memberships typicalities recursively cluster data uses participatory learning adapt model structure stream data input idea possibilistic clustering plays key role data noisy outliers due relaxation restriction membership degrees add unity fcm clustering algorithm show usefulness epfm approach addressed system identification using box jenkins gas furnace data well time series forecasting considering chaotic mackey glass series data produced synthetic time varying process parameter drift results show epfm potential candidate nonlinear time varying systems modelling comparable better performance alternative approaches mainly noise outliers affect data available
use surrogate models standard method dealing complex real world optimization problems first surrogate models applied continuous optimization problems recent years surrogate models gained importance discrete optimization problems article takes development consideration first part presents survey model based methods focusing continuous optimization introduces taxonomy useful guideline selecting adequate model based optimization tools second part examines discrete optimization problems six strategies dealing discrete data structures introduced new approach combining surrogate information via stacking proposed third part implementation approach available open source package spot article concludes discussion recent developments challenges continuous discrete application domains elsevier rights reserved
past decades research water acknowledged one main parameters influencing long term performance flexible pavements effect water factor considered designing structural geometrical pavements however unavoidably infiltrates pavement layered structures various mechanisms result additional drainage layers geocomposites considered among solutions available manage excess water flexible pavement structures paper presents analysis drainage structural behaviour full scale experimental pavements built various geocomposite drainage configurations tests conducted outdoor research facility laval university experimental pavement site following increase water table controlled drainage conditions drainage structural response experimental pavement sections measured using volumetric water content transducers falling weight deflectometer ten days overall results suggest lateral vertical drain best performing drainage configuration nevertheless several observations effect various drainage configurations according transversal vertical position pavement made using collected experimental data
present optimization approach employed calculate globally optimal segmentation magnetic system uniformly magnetized pieces segment algorithm calculates optimal shape optimal direction remanent flux density vector respect linear objective functional illustrate approach results magnet design problems different areas permanent magnet electric motor beam focusing quadrupole magnet particle accelerators rotary device magnetic refrigeration
questions people idiopathic parkinson disease week comprehensive home exercise program reduce falls disability improve health related quality life program cost effective design randomised controlled trial concealed allocation assessor blinding participants one hundred thirty three community dwelling adults parkinson disease intervention experimental group completed week home program comprising progressive resistance strength training movement strategy training falls education control group completed weeks non specific life skills training participants groups received weekly therapist guided sessions consecutive weeks weekly self directed home program outcome measures primary outcome rate falls documented month period immediately therapy secondary outcomes disability health related quality life assessed intervention month follow results total falls reported month follow proportion fallers experimental control groups respectively statistically significantly different significant group difference rate falls incidence rate ratio survival analysis participant time first fall show significant group difference log rank test significant group differences occurred mobility disability quality life mean cost delivering experimental intervention aud conclusion home program strength movement strategy training falls education prevent falls applied dose used study arguably dosage therapy insufficient future trials need explore therapy content repetitions duration order optimise outcomes cost effectiveness crown copyright published elsevier behalf australian physiotherapy association
background schizophrenia often characterized cognitive intellectual impairment however much heterogeneity across individuals suggesting different trajectories illness recent findings shown brain volume differences across subgroups individuals psychosis bipolar disorder intellectual cognitive impairments presented evidence early cerebral disruption cognitive intellectual impairments showed evidence progressive brain abnormalities aim investigate relations cognition intellectual functioning brain structure abnormalities sample compared unaffected individuals methods individuals healthy controls part northwestern university schizophrenia data software tool nusdast underwent neuropsychological assessment structural magnetic resonance imaging mri individuals divided subgroups according estimated premorbid crystallized intellectual epmc cognitive performance brain volumes differences investigated across groups results epmc cognitive impairments reduced total brain volume tbv intracranial volume icv tbv corrected icv cortical gray matter volume well reduced cortical thickness insula volumes cognitive impairment intact epmc showed reduced cortical gray matter volume cortical thickness conclusions data provide additional evidence heterogeneity impairments cognition associated reduced epmc related evidence broad brain structural alterations including suggestion early cerebral disruption contrast impaired cognitive functioning context intact intellectual functioning associated cortical alterations may reflect neurodegeneration
ecological vulnerability assessment key approach adaptation mitigation environmental degradation assess ecological vulnerability yinma river basin cold mountain region china ecological vulnerability index evi model established based integrated system dynamic model driving force pressure state impact response management dpsirm framework using multi sources data including meteorological remote sensing basic geographical sample socio economic data values evi calculated assessment results indicated overall ecosystem vulnerability conditions study area experienced degenerating trend extremely heavily moderately vulnerable zones mainly distributed north central southwest parts basin slightly lightly vulnerable areas distributed southeast part basin distribution ecological vulnerability grades administrative regions high rate slightly vulnerable level light vulnerable level appeared shuangyang district panshi city largest area rate moderately heavily extremely vulnerable level distributed dehui city nongan county jiutai district yitong county study demonstrated model could efficiently reflect dynamic mechanism basin ecological vulnerability results gained closely reflected reality study area elsevier rights reserved
cancer stem cell model claims initiation maintenance growth tumor driven small population cancer cells termed cancer stem cells cancer stem cells possess variety phenotypes associated therapeutic resistance often cause recurrence diseases several strategies investigated target cancer stem cells variety cancers blocking one self renewal signaling pathways reducing expression drug efflux atp binding cassette efflux transporters modulating epigenetic aberrations promoting cancer stem cell differentiation number cell animal studies strongly support potential benefits combining chemotherapeutic drugs cancer stem cell targeting agents clinical trials still underway address pharmacokinetics safety efficacy combination treatment mini review provides updated discussion preclinical clinical studies elsevier rights reserved
atrial natriuretic peptide anp increasingly expressed airway inhibits pulmonary arterial remodeling however role anp remodeling respiratory system still unclear role anp airway remodeling possible mechanism explored study human bronchial epithelial hbe cells alveolar epithelial cells stimulated tgf beta anp cgmp inhibitor pkg inhibitor cgmp analogue expressions epithelial markers mesenchymal markers smad assessed quantitative real time pcr western blotting immunohistochemical staining employed assess smad expression silenced sirna hbe cells results showed mrna protein expressions cadherin decreased whereas alpha sma expressions increased induction tgf beta hbe cells cadherin expressions increased alpha sma expressions decreased anp stimulation inhibition cgmp pkg decreased cadherin expression increased alpha sma expression could reversed cgmp analogue moreover phosphorylated smad expression consistent alpha sma expression smad silenced smad mostly expressed cytoplasm instead nucleus non silenced cells epithelial mesenchymal transition emt conclusion anp inhibits tgf beta induced emt hbe cells cgmp pkg signaling targets tgf beta smad via attenuating phosphorylation smad findings suggest potential anp treatment pulmonary diseases airway remodeling elsevier inc rights reserved
energy water important issues environmental impact buildings cities related closely study attempted analyze emission water usages sewage wastes also water saving strategies like installation water saving devices rainwater harvesting gray water system office buildings assess early design stage developed regional water amount regional emission factor water consequently estimated one sample office project korea suggested effective emission reduction plan water sector total amount emission water sector sample office building center dot
traveling virtually large scenes long distances different detail densities render fixed movement speeds impractical however manually adjust travel speed users control additional parameter may uncomfortable requires cognitive effort although automatic speed adjustment techniques exist many problematic indoor scenes therefore propose automatically adjust travel speed based viewpoint quality originally measure informativeness viewpoint user study show technique easy use allowing users reach targets faster use less cognitive resources choosing speed manually
paper focuses application electro hydraulic force tracking controller combined offline designed feedback controller odfc online adaptive compensator order improve force tracking performance electro hydraulic force servo system ehfs proportional integral controller employed parameter based force closed loop transfer function ehfs identified continuous system identification algorithm taking identified system model nominal plant model offline design method employed establish optimized feedback controller consideration performance control efforts robustness ehfs order overcome disadvantage offline designed controller cope varying dynamics ehfs online adaptive compensator normalized least mean square algorithm cascaded force closed loop system ehfs compensated odfc comparative experiments carried real time ehfs using xpc rapid prototype technology proposed controller yields better force tracking performance improvement isa published elsevier ltd rights reserved
longitudinal study aims analyze predictors posttraumatic stress symptoms ptss posttraumatic growth ptg among gender age objective factors disease treatment family environment factors negative emotionality sample consisted childhood cancer survivors girls boys aged years remission seven years four years survivors completed set questionnaires including benefit finding scale children university california los angeles posttraumatic stress disorder index regression correlation analyses performed relation ptss ptg proven higher level ptss associated higher levels negative emotionality higher level ptg connected higher level warmth parenting female gender older age assessment medical variables severity late effects time treatment completion play significant role prediction ptss ptg ptg ptss influenced factors parenting emotional well childhood cancer survivors objective medical data
hydromechanical compensators often integrated piston type pumps produce various control behavior example pressure load sensing power torque control various hydromechanical mechanisms spring forces load pressure found industry ensure desired effect system outputs swash angle discharge pressure input torque following reference inputs companion paper part paper generic linearized state space model derived investigate pump dynamics determine design criteria parameters study state space equations used propose define generic compensating control pump conduct similar strategies hydromechanical pumps different control purposes pressure flow power compensating accomplished manipulating generic regulate inputs given electrical proportional control valve open circuit pump generic controllers proposed generate inputs using one unique mechanical electronic architecture establish various purposes flow pressure torque desired control even control objectives controller developed accordance state space representation following models hydromechanical compensators facilitate correlation verification proposed controllers able offer intelligent cost saving control strategies open circuit piston pumps achieve similar performance hydromechanical compensators implement comparative study control gains settings controller determined ones hydromechanical compensators difference electronic signals swash plate position pressure etc work feedbacks together control gains regulate input signals different control purposes control gains able set conveniently various control operating conditions combining certain feedbacks hardware platform value efficient capable control intelligence paper results predictions made model presented compared experimental data hydromechanical designs work advanced model based control estimation anticipated addressed
background simple parapneumonic effusion pleural effusion associated lung infection pneumonia streptococcus pneumoniae remains common pathogen causing parapneumonic effusions morocco pneumococcal conjugate vaccine valent pcv introduced national immunization program october schedule prevention pneumococcal disease replaced pcv july schedule report case parapneumonic pleural effusions caused pneumoniae serotype child immunized doses pcv case presentation years old previously healthy moroccan female fully vaccinated pcv immunocompetent admitted private medical clinic six months history persistent asthma arrival february febrile degrees brutal flu syndrome chills dry cough serous rhinitis received symptomatic treatment biological assessment done confirmed clinical diagnosis flu seven days presented progressive deterioration general condition onset severe abdominal pain hospitalized second biological assessment computed tomography scans chest radiography done confirmed diagnosis pneumococcal parapneumonia abscess left lower lobe encysted empyema microbiological analysis pleural fluid showed pneumoniae serotype susceptibility intermediate penicillin patient treated antibiotics including amoxicillin cefixime ceftriaxone vancomycin conclusions reported case parapneumonic pleural effusions caused vaccine serotype pneumococcal occurring immunocompetent child immunized doses pcv
regulatory cells regs recognized central mediators maintaining peripheral tolerance limiting autoimmune diseases loss regs function associated exacerbation autoimmune disease however temporary loss regs chronic spontaneous disease model investigated study evaluated role regs novel chronic spontaneous glomerulonephritis model cell lymphoma interacting mediator bim knock mice transient depleting regs bim pro apoptotic member cell lymphoma bcl family bim knock bim mice fail delete autoreactive cells thymus leading chronic spontaneous autoimmune kidney disease found reg depletion bim mice exacerbated kidney injury increased proteinuria impaired kidney function weight loss greater histological injury compared wild type mice significant increase interstitial infiltrate inflammatory cells antibody deposition tubular damage furthermore serum levels cytokines interleukin interferon ifn tumour necrosis factor tnf increased significantly reg depletion bim mice study demonstrates transient depletion regs leads enhanced self reactive effector cell function followed exacerbation kidney disease chronic spontaneous kidney disease model bim deficient mice
phase study performed evaluate efficacy safety jak inhibitor ruxolitinib chinese patients ruxolitinib given twice day bid starting dose based baseline platelet count patients achieved reduction spleen size exhibited significant reduction week significant improvement debilitating constitutional symptoms assessed mfsaf observed patients treated ruxolitinib ruxolitinib treatment generally well tolerated chinese patients although treatment associated increase certain adverse events aes established identified risks anemia thrombocytopenia aes considered manageable clinical setting ruxolitinib provided substantial reductions splenomegaly improvements symptoms well tolerated chinese patients
background prevalence cutaneous adverse food reactions cafrs dogs cats precisely known imprecision likely due various populations studied objectives systematically review literature determine prevalence cafrs among dogs cats pruritus skin diseases results searched two databases pertinent references august among articles respectively found web science science citation index expanded cab abstract databases selected nine articles reported data usable cafr prevalence determination dogs cats respectively prevalence cafr dogs cats found vary depending upon type diagnoses made among dogs presented veterinarian diagnosis prevalence among skin diseases ranged range cafr prevalence similar dogs pruritus type allergic skin disease dogs diagnosed atopic dermatitis cats presented university hospital prevalence cafr less fairly homogeneous cats skin diseases range higher cats pruritus cats allergic skin disease conclusions among dogs cats pruritus suspected allergic skin disease prevalence cafr high enough justify syndrome ruled restriction elimination provocation dietary trial must especially considered companion animals nonseasonal pruritus signs allergic dermatitis
hysterectomy frequently performed major gynecologic surgery women united states procedure often accompanied unilateral bilateral removal fallopian tubes ovaries although overall incidence bilateral salpingo oophorectomy shown decreasing trend recent years possibly common scenarios gynecologic surgeon encounter field minimally invasive surgery continues expand expected surgeries performed using laparoscopic approach fact data support adnexal surgery likely take place laparoscopic hysterectomy compared abdominal vaginal routes article reviews basic surgical principles relevant anatomic relations every pelvic surgeon know aims serve guide effectively proficiently performing salpingo oophorectomy time hysterectomy aagl rights reserved
propose novel vehicle energy system ves integration organic rankine cycle orc vehicle air conditioning considered thermal economic performance system investigated comparing conventional ves ves standalone orc exhaust heat recovery hydrocarbons including propane cyclopentane hydro fluorocarbons including rfa selected working fluids energy system systematically study influences integration vapor compression refrigeration vcr orc subsystems different operating conditions results indicate proposed system holds advantages regarding overall thermal economic performance compared conventional ves proposed system improves overall thermal efficiency reduces diesel consumption compared conventional ves different working fluids considered lead payback periods range efficient working fluid integrated vcr orc subsystem ves operating conditions considered research elsevier ltd iir rights reserved
paper describes approach developed model current return networks installed aboard aircrafts parts made composite materials surface partial element equivalent circuit peec method adopted high fidelity modeling capabilities accuracy low frequency region interest characterization return networks state art peec modeling implemented order allow real life aircrafts modeled special complex mock realized measured numerical results compared measurements assess adequacy
negative features false memories frequently foreground false memory research however become increasingly apparent false memories also positive consequences two experiments examined positive consequences false memories participants visually presented false memory word lists received recognition task modified perceptual closure test participants received degraded visual representations words false true unrelated items became clearer time participants identify fast possible identifications based false memories significantly faster based true memories related items roughly similar pattern observed recognition task used critical lures replaced items experiment results indicate false memories beneficial problem solving tasks counter standard perspective false memories inherently negative nature society applied research memory cognition published elsevier inc rights reserved
background pulmonary arteriovenous malformations pavms present approximately individuals hereditary hemorrhagic telangiectasia hht may isolated often multiple goal study evaluate influence pavms lung mechanical properties methods reviewed files adult patients age years referred center evaluation hht diagnosis hht based curacao criteria presence pathogenic mutation exclusion criteria included chronic cardiac lung disease asthma copd suspicion pulmonary hypertension echocardiography current past smoking pack years history thoracic surgery previous treatment pavms embolotherapy lung infection thromboembolic disease past months pregnancy obesity bmi chest high resolution scan pulmonary function tests performed day patients part routine work results one hundred fifty five patients hht included age yrs mean males eighty eight patients pavm pavms least pavms thirty eight patients unilateral pavms bilateral pavms found statistical relationship number size laterality pavms results lung flows volumes conclusion found evidence pavms significant influence lung mechanical properties measured using routine pulmonary function tests adult patients hht even case numerous macroscopic bilateral malformations
background beckman coulter developed veris hcv assay use new fully automated dxn veris molecular diagnostic system sic hcv viral load monitoring objectives evaluate clinical performance new quantitative veris hcv assay study design comparison performed plasma specimens hcv infected patients tested veris hcv assay cobas ampliprep cobas tagman hcv test specimens tested veris hcv assay realtime hcv assay patient monitoring sample results four time points also compared results average bias veris hcv assay cobas ampliprep cobas tagman hcv test log veris hcv assay realtime hcv assay average bias log bias however consistent across measuring range analysis lower end quantification levels showed predicted bias veris hcv assay versus cobas ampliprep cobas tagman hcv test log veris hcv assay versus realtime hcv assay log patient monitoring hcv viral load time demonstrated similar levels veris hcv assay results cobas ampliprep cobas tagman hcv test samples patients realtime hcv assay samples patients conclusions veris hcv assay use dxn veris molecular diagnostic system represents reliable new tool easy sample result hcv rna viral load monitoring elsevier rights reserved
problem classifying traffic flows networks become important recent times much research dedicated recent years lot interest classifying traffic flows application based statistical features flow information applications used network useful network design accounting management security previous work proposed classification algorithm internet traffic flow classification based artificial immune systems ais also applied algorithm available data set found algorithm performed well algorithms insensitive input parameters makes valuable embedded systems also simple implement generalizes well small training data sets research expanded previous research introducing several optimizations training classification phases algorithm improved design original algorithm order make predictable also give asymptotic complexity optimized algorithm well draw bound generalization error algorithm lastly also experimented several different distance formulas improve classification performance paper shown changes optimizations applied original algorithm functionally change original algorithm making execution faster also show classification accuracy euclidian distance superseded manhattan distance application giving higher accuracy making accuracy algorithm comparable naive bayes classifier previous research uses data set published elsevier
background alcohol use among adolescents widespread growing concern due long term behavioral deficits including altered pavlovian behavior potentially contribute addiction vulnerability tested hypothesis adolescent intermittent ethanol aie exposure alters pavlovian behavior males females measured shift goal tracking sign tracking additionally investigated glt astrocytic glutamate transporter potential contributor sign tracking phenotype methods male female sprague dawley rats exposed aie intragastric water intermittently days days postnatal day around animals began daily sessions pavlovian conditioned approach pca learned cue predicted noncontingent reward delivery lever pressing indicated interaction cue sign tracking receptacle entries indicated approach reward delivery location goal tracking test effects aie nucleus accumbens nacc excitatory signaling isolated membrane subfractions measured protein levels glutamate transporter glt animals completed behavior measure glutamate homeostasis results females exhibited elevated sign tracking compared males significantly lever presses faster latency first lever press greater probability lever press trial aie significantly increased lever pressing blunting goal tracking indicated fewer cue evoked receptacle entries slower latency receptacle entry lower probability enter receptacle trial significant sex exposure interactions observed sign goal tracking metrics moreover found significant effects sex exposure membrane glt expression nacc conclusions females exhibited enhanced sign tracking compared males aie decreased goal tracking compared control exposure findings support hypothesis adolescent binge ethanol shift conditioned behavior goal cue directed pca especially females
purpose review purpose study briefly review molecular mechanisms leads structural damage ankylosing spondylitis defined new bone formation resulting complete incomplete ankylosis spine impact treatment biologics retard process recent findings understanding molecular mechanisms leading new bone formation significantly improved still incomplete availability biologics greatly enhanced treatment patients impact slowing structural damage still matter debate although observational studies shown long term use tnf blockers may slow radiographic progression availability newer biologics targeting shown promising results slowing radiographic progression summary although availability tnf inhibitors greatly enhanced treatment options patients impact slowing structural damage still clearly established however preliminary results using newer biologics targeting axis encouraging longer follow needed
paper report discusses theft prevention system prevent theft also track object system capable tracking vehicle well theft prevention module use exchange information regarding vehicle owner vehicle police control room sos services vehicle track help receiver dtmf based fuel lock attached system cell phone sim card attached dtmf fuel flow vehicle controlled give call cell phone system controlled microcontroller make system cost effective low power consumption effective reliable
urban stormwater runoff management systems usually designed meet performance standards based historical climate data assumed stationary based evidence climate change impact studies near future stormwater management systems within built environment may need meet performance expectations climatic conditions different historical climate considering impacts climate change rainfall intensities stormwater runoff peak flow volumes turn effectiveness mitigation practices urban stormwater management desirable paper presents results climate change impact study urban stormwater runoff bronx river watershed new york city considering impacts climate change watershed runoff potential low impact development lid controls mitigate impacts investigated stormwater runoff lid controls modeled using epa storm water management model version epa swmm simulations driven historical precipitation modified represent future projections using change factor methodology based precipitation coupled model intercomparison project phase cmip using change factor method historical precipitation perturbed obtain future data based three climate scenarios projecting maximum mean minimum values rainfall results frequency analysis performed simulated peak flow rates different recurrence intervals showed noticeable increase frequency occurrence extreme storm events peak values future extreme climate conditions lid control scenario consisting rainwater harvesting porous pavement bioretention designed evaluated using swmm model results showed average increase historical annual runoff volume climate change impacts approximately lid controls could provide average reduction annual runoff volume application lid controls also reduced peak flow rates average lid implementation decreased watershed runoff corresponding year year return periods respectively conclusion retrofits lid controls may provide inherent benefits runoff volume water quality also additional climate impact mitigation benefits stormwater runoff american society civil engineers
acceptance key construct rational emotive behavior therapy rebt acceptance commitment therapy act objectives study assess compare properties act acceptance rebt acceptance predicting emotions sample subjects comprising different educational occupational status completed three measures acceptance rebt act two mindfulness well completing depression anxiety scales act acceptance process rebt acceptance could predict significant act acceptance outcome mindfulness trait also predicted level act outcome acceptance well level rebt acceptance mindfulness process predicted act outcome acceptance results show rebt acceptance act acceptance mindfulness explain anxiety depression different ways results show difference act acceptance rebt acceptance primary concern process acceptance likely due underlying cognitive processing outcome acceptance emotional level similar two conditions future research employ multiple cognitive measurements
view future healthcare sense big changes afoot many revolve around plans repeal replace affordable care act speculate potential areas change context set tenets care older persons address
gut microbiota recently emerged important regulator brain physiology behaviour animals ingestion certain bacteria probiotics therefore appear potential treatment major depressive disorder mdd however conceptual mechanistical aspects need elucidation therefore aimed investigating whether habitual diet may interact effect probiotics depression related behaviour examined potentially involved mechanisms underlying microbe mediated behavioural effects forty male sprague dawley rats fed control con high fat diet hfd ten weeks treated either multi species probiotic formulation vehicle last five weeks independently diet probiotic treatment markedly reduced depressive like behaviour forced swim test furthermore probiotic treatment skewed cytokine production stimulated blood mononuclear cells towards ifn gamma expense tnf alpha addition probiotics lowered hippocampal transcript levels factors involved hpa axis regulation crh crhr whereas hfd increased levels non targeted plasma metabolomics analysis revealed probiotics raised level indole propionic acid potential neuroprotective agent findings clearly support probiotics potential treatment strategy mdd importantly efficacy attenuated intake western pattern diet associated mdd mechanistically hpa axis immune system microbial tryptophan metabolism could important context importantly study lend inspiration clinical trials probiotics depressed patients elsevier ltd rights reserved
purpose currently treatment emergent adverse events teaes clinical study summarized entire study period objective develop validate novel methodology burden therapy quantify presence severity teaes day study methods utilizes patient level safety data derive quantitative estimate burden teaes individual patients experience day clinical study burden estimate day based number severity teaes chart displays total burden experienced patients day throughout study statistical analyses may performed area curve methodology applied two validated published clinical studies statistically analyzed results peripheral neuropathic pain study topical group greater incidence teaes oral anticonvulsant group evaluated using current methodology utilizing teaes topical agent short duration occurred three days application whereas teaes oral agent increased dose titration persisted study end overactive bladder study minimal difference overall teaes groups revealed higher burden related dry mouth antimuscarinic versus adrenergic agonist group conclusions highly sensitive method evaluate comparative burden experienced patients treatment facilitate better informed treatment selection propose new standard analyzing safety clinical studies authors published elsevier inc open access article license
new approach based part diffusive equilibrium developed model dynamic content plsmaspheric magnetic flux tubes called global plasmasphere lonosphere density gpid model aim reproduce main dynamic features complete field line interhemispheric plasma flip model simpler formulation allows rapid computation ions temporal variation magnetic flux tube simultaneously modelling several thousand flux tubes global representation plasmasphere obtained realistic time frame global model allows plasmaspheric contribution total electron content tec measured global position system gps satellite radio signals determined removed hence permitting underlying ionosphere observed paper presents approach used model single magnetic flux tube gpid assumes lonosphere plasmasphere composition includes chemical processes simple diffusive transport almost situations gpid reproduces predictions flip model comparisons gpid refilling fluxes obtained whistler observations generally show good agreement diurnal variations prolonged refilling empty flux tubes comparisons seasonal variations solar maximum show good agreement observations solar minimum variable agreement elsevier science ltd rights reserved
paper tallies links fluid mechanics quantum mechanics attempts show whether links aid beginning build formal template usable economics models time symmetric memory absent present objective paper contemplate whether formalisms allow model information economics novel way
paper presents new design electronic fixed calliper based wedge brake system movement sides brake piston activated wedge block mechanism proposed fixed calliper based electronic wedge brake system class hydraulic free device mechanism consists two sets wedge blocks ball screw drive shaft sliding beam electric motor mechanism rotation shaft electric motor converted linear motion using ball screw drive shaft linear motion drive shaft force sliding beam displaced linearly activate wedge mechanism cause pad displaced tangentially disc brake movement pad pressing disc generate clamping force produce brake torque wheel rotates study mathematical model system generates clamping force identified model based second order transfer function proposed mathematical model validated experimentally using brake test rig installed several sensors input output device performance brake mechanism term rotational input drive shaft clamping force produced brake observed accordingly torque tracking proportional integral derivative pid control system proposed studied simulation experiment comparisons experimental results model responses made found trend simulation results experimental data similar acceptable level error
since establishment people republic china chinese government encountered several catastrophes related transfusion transmitted diseases government increasing attention blood safety prompted initiation series policies measures enhanced level safety blood supply met basic clinical demands blood billion people country blood donation screening strategies china predominantly comprise donor screening donor testing donor screening includes selection low risk blood donors use donor history questionnaire predonation physical examination initial rapid donor testing donor testing includes direct pathogen detection serology tests year marked transformative change blood donor selection screening policies china paid donation predominant mode blood donation donor screening donor testing conducted donation eligible allowed donate ensure safety blood donor testing performed donation implementation blood donation law promote voluntary unpaid donation predonation donor testing eliminated reduce amount waiting time provide convenient donation experience blood donors however national requirement donated blood undergo rounds testing using different equipment reagents conducted different personnel donor selection transitioned paid donation obligatory donation voluntary donation fixed volunteer groups latter mode donation provides lowest risks donations currently screened syphilis hepatitis virus hiv hepatitis virus hbv units previously typed abo routinely tested abo innovations testing technologies methods also brought changes screening parameters instance screening hbv pathogens evolved early use hemagglutination method later use radioimmunoassay independent enzyme linked immunosorbent assay widespread application nucleic acid test nat since chinese government established nat capacity several blood centers government invested million rmb nationwide expansion nat although chinese government worked enhance blood safety many challenges remain concern exists rising rates hiv infection existence occult hbv infection transmission emerging blood borne diseases continue challenge safety blood supply elsevier inc rights reserved
recently death anxiety dread death proposed key transdiagnostic process underlying anxiety disorders depressive disorders somatic disorders trauma stressor related disorders fact argued death anxiety underlies psychopathology fundamental perfectionism process previously considered root mental illness however paucity research examining relationship death anxiety eating disorders although conditions found strongly related perfectionism present study therefore aimed examine whether death anxiety related disordered eating whether death anxiety better predictor disordered eating perfectionism sample participants female average age years years completed online survey comprising background questions age sex diagnosed psychiatric disorder eating attitudes test item version eat almost perfect scale revised aps rosenberg self esteem scale rses death anxiety scale das findings hierarchical multiple regression analysis eat dependent variable age entered step rses aps entered step das entered step showed death anxiety self esteem independent predictors disordered eating step simultaneous multiple regression analysis subsequently run age aps alone predictors eat scores analysis showed perfectionism predictor disordered eating death anxiety self esteem included regression model death anxiety self esteem appear important transdiagnostic processes
wireless sensor networks based structural health monitoring widely researched make better structural health monitoring real time acquisition structural responses indispensable however data large number especially moving structures difficult measured adaptation wireless sensor networks limits structural health monitoring within capacity radio frequency study cochlea inspired artificial filter bank developed technological way efficiently acquire dynamic responses wireless sensor networks based structural health monitoring cochlea inspired artificial filter bank developed article enabled acquire valid dynamic responses compressed size around frequency range interest simulating raw data full regarding time frequency dynamic responses addition digitalized cochlea inspired artificial filter bank also found fix disadvantages analogue filters easy efficient development logics optimization design software real time autonomous execution finally cochleainspired artificial filter bank makes possible compress reduce vast amount real time dynamic responses usually obtained means uniform rate sample manageable size thus expected open new paradigm wireless sensor networks based structural health monitoring civil structures facilitating efficient measurement management data base
segmentation methods evaluation important problems computer graphics many segmentation techniques available literature efficiently evaluate methods important issue paper propose new objective evaluation metric suitable evaluation segmentation methods based dice coefficient dice coefficient similarity coefficient designed compute degree similarity sample data sets extend approach mesh segmentation evaluation since regions segmented mesh seen sample data sets many existing metrics take consideration irregularity meshes proposal integrate surface faces adaptation dice coefficient evaluate segmentation regular irregular meshes experimental results confirm potential proposed metric
contribution propose dynamic gradient damage model phase field approach studying brutal fracture phenomena quasi brittle materials impact type loading conditions several existing approaches account tension compression asymmetry fracture behavior materials reviewed better understanding models provided uniaxial traction experiment give efficient numerical implementation model explicit dynamics context simulations results obtained parallel computing discussed computational physical point view different damage constitutive laws tension compression asymmetry formulations compared respect aptitude approximate brittle fracture copyright john wiley sons ltd
objective aim study examine whether physicians better informed large published hormone therapy trials women health initiative likely prescribe menopausal symptoms methods obstetricians gynecologists primary care physicians completed minute internet based survey knowledge assessed via nine true false statements trials range prescribing practices assessed via six case studies seven point response scale extremely unlikely extremely likely relation treatment options range primary analysis examined correlation trial knowledge likelihood prescribing secondary analyses gauged knowledge prescribing practices based practice type sex years practice results among physicians completed survey representing invited median age female obstetricians gynecologists median practice knowledge mean prescribing mean exhibited statistically significant moderate positive correlation obstetricians gynecologists significantly knowledgeable likely prescribe primary care physicians male physicians likely prescribe knowledgeable female physicians knowledge likelihood prescribing significantly increased function years practice conclusions physicians knowledgeable large published trials likely prescribe menopausal symptoms
article solution problem increasing efficiency drilling bit stage manufacture proposed method solving task offered authors consists integration automatic contactless contact stylus method control elements pairs leg cutter drilling bit production conditions authors give detailed justification offered automatic control methods form special devices schemes descriptions work devices also calculations main characteristics construction device contact stylus control provided algorithm excluding time costs calculations determine group received size roller way leg cutter developed authors managing sorting devices solutions proposed authors used manufacturing engineering also modernization acting facilities requirement receiving selection couple parts roller way
modern times efforts construct sustainable alternative neighbourhood scale developments date isolated voluntary initiatives europe united states since increased rapidly popularity many names ecodistricts ecoquartiers eco cities zero low carbon carbon positive cities ecopolises ecobarrios one planet communities solar cities become framessometimes dominant frameused orient construction new pieces city growing number countries despite numerous standardization efforts field ecourban neighbourhood planning practice lacks consistent cross cultural understanding constitutes meaningful ecourbanism specific economic political ecological social design based terms ecourban neighbourhood projects also respond strictly local challenges opportunities express fragmented ways different contexts article presents original typology ecourbanism integration seven extreme type principles developed typology abductive approach back forth testing observed practices arguments advanced theories sustainable development planning urban studies ecourban neighbourhood developments definition express integrative goals typology permits assessment extent outcomes achieved terms specific principle define present limiting case extreme type principles rather attempting render different standards equivalent across national contexts typology based approach understand outcomes ecourban neighbourhood developments promises means facilitate orienting developments toward higher levels integration within common set principled boundaries developed around world
paper surveys value systems developmental cognitive robotics value system permits biological brain increase likelihood neural responses selected external phenomena many machine learning algorithms capture essence learning process however computational value systems aim support learning also autonomous attention focus direct learning combination unsupervised attention focus learning aims address grand challenge autonomous mental development machines survey examines existing value systems developmental cognitive robotics context examine definitions value used including recent pioneering work intrinsic motivation value well initialisation strategies innate values update strategies acquired value data structures used storing value examine extent existing value systems support attention focus learning prediction unsupervised setting types robots applications value systems used also examined well ways applications evaluated finally study strengths limitations current value systems developmental cognitive robots conclude set research challenges field elsevier rights reserved
self cutting injuries low mortality rate type injuries special clinical significance potential leading devastating disability repeated suicide attempts purpose study analyze nature outcomes wrist cutting injuries retrospective study designed order investigate suicide attempts wrist cutting attended uludag university faculty medicine emergency department june december patients analyzed age gender alcohol intake psychological state prior suicide attempts clinical features injury side injury pattern used tool seen severity wrist cutting injury variates gender age alcohol drug consumption diagnosed psychiatric disorder create higher risk extensive wrist lacerations seen skin lacerations likely repeat act therefore need psychiatric intervention level iii retrospective study
soliton interactions coupled nonlinear schrodinger equations governing propagation envelopes electromagnetic waves birefringent optical fibers investigated symbolic computation based hirota method analytic two three soliton solutions model derived relevant interaction properties discussed stationary bound vector solitons periodic attraction repulsion obtained soliton intensity could reduced nonlinearity optical fibers enlarged soliton period could prolonged group velocity dispersion anomalous dispersion regime optical fibers increases asymptotic analysis two soliton solutions interactions two solitons proven elastic besides parallel soliton transmission systems without soliton interactions presented moreover interactions regular bound vector solitons studied dual complex structures triple soliton bound states presented results could certain value studies soliton control optical switching technologies
demonstrate coherent polarization beam combination two channel picosecond pulses based microcontroller based phase locking method simple low cost technique enables easy programming automatic relocking relative phases two fiber amplifiers total average power combined laser corresponding combining efficiency microcontroller based phase locking method provides competitive solution robust programmable control phases active coherent polarization beam combining system
common non malignant age related disease men benign prostatic hyperplasia bph androgens genetic predisposition play important roles normal prostate growth bph progression however accumulating evidence indicates factors aging obesity also contribute bph etiology management bph includes medical treatment surgery currently drug therapy uses alpha blockers inhibitors alpha reductase enzyme aris latest studies demonstrated fraction patients resistant therapy article reviews new risk factors bph etiology well mechanisms resistance ari therapy
larger scale railway construction china larger scale tunnel projects process tunnel engineering constructions difficult high risk many unpredictable factors may cause safety issues landslides roof caving water bursts threatening construction personnel safety personnel positioning tracking systems studied applied preliminarily railway tunnel construction important know many people underground workers must sign one one tunnel entrances come leave process time consuming sometimes irritating line must exit one one sign active radio frequency identification rfid systems respond transponders personnel helmets jackets quickly identify workers coming going without stopping sign also alert management person enters without transponder indoor moving target recognition tracking internet things popular research application topic recent years paper proposes indoor moving target recognition tracking method based rfid charge coupled device ccd collaborative information fusion first rfid technique proposed extended virtual reference elimination extended virtual reference elimination approach used recognize coarsely locate target second based coarse localization results monitoring sleeping control different ccds realized subsequently background difference method used detect target ccd monitoring image realize precise localization multiple angle view fusion finally weighted average two localization results moving target location obtained method combines advantages rfid fast recognition localization ccd precise localization experiment results indicate proposed collaborative information fusion method effectively improve accuracy real time performance indoor moving target tracking
paper focuses design optimization stand alone hybrid microgrid serving inhabitants community located rural area bihar india investigates potential use wood biomass electricity generation economic performance different power generation configurations evaluated simulating microgrid operation four periods five days representative whole year time step min system operation defined energy management system ems ensures demand different goods community power heating domestic hot water cooling water irrigation domestic use satisfied minimum operational cost thanks proper optimization programmable units scheduling time step cost effective schedule obtained using mixed integer linear programming milp embedded rolling horizon approach considering start penalties battery wear cost ramp limits component operational constraints three different system configurations investigated first one considers combination photovoltaic panels diesel internal combustion engine ice two investigate possibility substitute fossil fuel generator renewable energy dispatchable generator powered wood biomass draft gasifier coupled ice boiler coupled organic rankine cycle orc obtained results show integration renewable energy sources technologies beneficial effect lcoe isolated microgrids introduction panels allows optimal case lcoe reduction comparison system based diesel engine twice much decrease attainable using biomass main energy source gasifier based orc based systems show similar economic performances ensure share electricity generated renewables elsevier ltd rights reserved
recent development nanotechnology resulted growing various nanoplate like structures high attention devoted graphene sheet nanostructure enforced scientist start developing various theoretical models investigate physical properties magnetic field effects nanoplates especially graphene sheets also attracted considerable attention scientific community using nonlocal theory examine influence plane magnetic field viscoelastic orthotropic multi nanoplate system vomnps embedded viscoelastic medium derive system partial differential equations describing free transverse vibration vomnps uniaxial plane magnetic field using eringen nonlocal elasticity kirchhoffs plate theory considering viscoelastic orthotropic material properties nanoplates closed form solutions complex natural frequencies derived applying navier trigonometric method case simply supported nanoplates results obtained analytical method validated results obtained using numerical method addition numerical examples given show effects nonlocal parameter internal damping damping stiffness viscoelastic medium rotary inertia uniaxial plane magnetic force real imaginary parts complex natural frequencies vomnps study useful starting point research design nanoelectromechanical devices based graphene sheets elsevier masson sas rights reserved
ary cube one attractive interconnection networks parallel distributed computing systems paper investigate hamiltonian cycle path embeddings ary cubes based structure faults means faulty element isomorphic connected subgraph connected graph let connected graph show two arbitrary distinct healthy nodes faulty exists fault free hamiltonian path connecting two nodes number faulty element certain number faulty element isomorphic connected subgraph also show exists fault free hamiltonian cycle number faulty element certain number faulty element isomorphic connected subgraph results mean ary cube qnk tolerate faulty nodes still hamiltonian hamiltonian connected denotes faulty set
yellow fever virus yfv replication highly dependent host cell factors yfv nsb reported involved viral replication immune evasion interactions nsb human proteins determined using gst pull assay analyzed using present total proteins confirmed using scaffold software cyclophilin cypa protein shown necessary positive regulation flavivirus replication identified possible nsb partner proteins found significantly increased compared negative control cypa exhibited greatest difference fold change fisher exact test significant proteins value cypa significant ingenuity systems software identified pathways analysis indicated sirolimus mtor pathway inhibitor potential inhibitor cypa immunofluorescence viral plaque assays showed significant reduction yfv replication using sirolimus cyclosporine csa inhibitors furthermore yfv replication strongly inhibited treated inhibitors using reporter bhk rep yfvdlucneolres cells taken together data suggest cypa nsb interaction regulates yfv replication finally present first evidence yfv inhibition may depend nsb cypa interaction
paper new pulse width modulation pwm converter proposed structure converts analog input signal pwm waveform using inverters charge pumps combination passive elements thus proposed pwm converter need operational amplifier added feedback path current used adjust required duty cycle pwm conversion based dynamic range input signal behavior proposed pwm converter formulated simulated cmos technology simulation results proposed pwm converter achieves linearity draws mhz supply process
changing manufacturing environment characterized aggressive competition global scale rapid changes manufacturing processes related technologies requires creation education systems easily upgradable new syllabi functions readily integrated according report next generation manufacturing new environment calls hands experiences laboratories modularity integrability customization open architecture key features also emphasis teamwork innovation leadership part new curricula manufacturing engineering education paper discusses concepts presents ideas design courses labs support new curricula
environmental impact building industry significant construction industry constitutes major part world total energy consumption result building designers constantly urged pay attention energy economics buildings green building practices like passive solar building design advanced construction building operation practices evolved years passive solar architecture basically refers usage structural non structural elements building comfort conditions additional operational costs makes best possible use local geographic climatic conditions measures help decreasing operational costs building increasing thermal comfort occupants often leading enhanced productivity energy efficiency measures also improve building marketability cost operation reduced temperature inside building one factors identity comfort level great extent hence necessary predict internal air temperatures building study attempt made developing mathematical models could predict air temperature inside building works attempts development neural network regression tool predict temperature inside simple construction fed various building specifications input results artificial neural network found close agreement actual site recorded data first time ann used application purpose validation testing data recorded four rooms varying architectural aspects past year taken recordings taken hourly basis
objectives study adds multilevel perspective well researched individual level relationship job resources work engagement addition explored whether individual job resources cluster within work groups shared psycho social environment investigated whether resource rich psychosocial work group environment beneficial employee engagement beneficial effect individual job resources independent variability within groups methods data employees nested work groups obtained baseline employee survey large stress management intervention project implemented six medium large sized organizations diverse sectors variety important job resources assessed grouped overall job resource factor three sub factors manager behavior peer behavior task related resources data analyzed using multilevel random coefficient modeling results results indicated job resources cluster within work groups aggregated group level job resources construct however resource rich environment indicated high group level job resources additionally benefit employee work engagement contrary negatively related conclusions basis unexpected result replication studies encouraged suggestions future studies possible underlying within group processes discussed study supports presumed value integrating work group relevant psychosocial environment motivational process indicates need investigate emergent processes involved aggregation procedures across levels
randall collins interaction ritual theory suggests social solidarity hardwired human neurological capacity rhythmic entrainment yet article suggests theory may benefit tied firmly recent neurobiological research specifically stephen porges polyvagal theory proposes autonomic nervous system functioning basis emotions social behavior perspective theory sufficiently acknowledge human nervous system system involving phylogenetically ordered response hierarchy one subsystem supports prosocial behavior ritual ingredients mutual attention shared mood may moreover specified part social engagement system neurally regulating attention emotional arousal via face heart connection article suggests social engagement system provides part neural basis rhythmic entrainment polyvagal theory furthermore challenges theory reconsider importance individual biological differences ritual success may merely ascribed interactional effects also reciprocal causality situations neurobiological properties ritual participants
studying developing new television system based methodology delivers text based scripts internet representing visual contents instead transmitting visual content format video data text generated system achieved technology called tvml program making language enabling create program like computer graphics animation automatically script one problems development establish scheme program production tvml get quality contents like real broadcast approach problem analyze real program mimic tvml first choose reference program analyze many aspects based acquired knowledge transfer findings production made using tvml make copy original show faithful possible objective attempt reveal essential elements would needed obtain full program quality paper describe mimicking process news show result tvml production comparison original evaluation result conducted testers finally discuss pros cons production applied produce news show shed light problems
limited data regarding influence commissural malalignment aortic pulmonary sinus arterial switch operation compare diagnostic accuracy cardiac echocardiography evaluating commissural malalignment aortic pulmonary sinus children complete transposition great arteries seek potential clinical implication commissural malalignment arterial switch operation patients boys median age days range days complete transposition great arteries tricuspid semilunar valves underwent arterial switch operation degree commissural rotation aortic pulmonary sinus assessed cardiac echocardiography surgical finding reference cardiac compared echocardiography identifying commissural malalignment patients influence height difference semilunar valves measured cardiac identification commissural malalignment cardiac echocardiography evaluated impact commissural malalignment coronary transfer techniques evaluated operative findings commissures semilunar valves aligned patients malaligned surgical findings reference cardiac showed higher statistically significant sensitivity specificity accuracy diagnosis malalignment echocardiography measured height difference semilunar valves affect identification malalignment cardiac echocardiography surgical malalignment group showed higher requirement modified coronary transfer techniques surgical aligned group cardiac echocardiography appear useful evaluating commissural malalignment semilunar valves patients complete transposition great arteries frequently requiring modified coronary transfer techniques arterial switch operation
background atopic dermatitis inflammatory skin disorder severe pruritus despite advancements medicine therapeutic treatments still limited eupatilin dihydroxy trimethoxyflavone one lipophilic flavonoids artemisia umbelliformis lam artemisia genipiweber objective although reported act role improving inflammation action uncertain study examined role eupatilin like skin lesions nga mice methods dinitrochlorobenzene repeatedly applied ear nga mice produce like skin lesions eupatilin day consecutive days week applied topically four weeks evaluation therapeutic effects results eupatilin cream significantly reduced clinical severity score like lesions compared vehicle histopathological analysis revealed eupatilin cream significantly decreased mast cell infiltration well inflammatory cell infiltration compared vehicle showed eupatilin cream significantly reduced expression thymic stromal lymphopoietin tumor necrosis factor alpha interleukin interleukin interferon gamma compared vehicle conclusion considering therapeutic reaction eupatilin like lesions study substance promising adjuvant topical agent control
paper describes modular architecture based dual active bridge dab converter input series output parallel isop connection work focused input voltage sharing ensure proper operation module means active control input output voltages small signal model modular architecture proposed decoupled control loops scheme used implement control strategy experimental setup built order validate model dab converter isop connection proposed control strategy taking different operating conditions constructive parameter values account
selection filter plays important role internal model control imc based controller design per rule minimum phase delay free plant imc based controller obtained augmenting filter suggest use first order filter controller design parameterized conventional pid controller proposed scheme brings filter size reduction closed loop bandwidth enhancement easy formulation pid structure proposed scheme applied class linear nonlinear processes hardware testing velocity control precision modular servo system contains servomotor carried scheme quantitative comparison servo regulatory optimal attributes proposed scheme popular imc pid control techniques depicts sharp reference tracking good disturbance rejection minimum integral error performance
new reference resistance design rrd method recently developed rotter manual dimensioning metal shell structures effectively permits analyst working calculator spreadsheet take full advantage realism accuracy advanced nonlinear finite element calculation method achieves reformulating outcomes vast programme parametric calculations terms six algebraic parameters two resistances representing physical aspect shell behaviour formidable challenge establish parameters resistances important shell geometries load cases systems received far research attention rrd cylindrical shell uniform axial compression uniform bending partial algebraic characterisations required thousands finite element calculations performed across four dimensional parameter hyperspace length radius thickness ratio imperfection amplitude linear strain hardening modulus handling many nonlinear finite element models time consuming quantities data generated overwhelming paper illustrates computational strategy deal issues may help researchers establish sets rrd parameters important shell systems greater confidence accuracy methodology involves full automation model generation submission termination processing object oriented scripting illustrated using code pseudocode fragments authors published elsevier ltd
phat open source library computation persistent homology matrix reduction targeted towards developers software topological data analysis aim simple generic design decouples algorithms data structures without sacrificing efficiency user friendliness provide numerous different reduction strategies well data types store manipulate boundary matrix compare different combinations extensive experimental evaluation identify optimization techniques work well practical situations also compare software various publicly available libraries persistent homology elsevier ltd rights reserved
background volumetric atrophy microstructural alterations diffusion tensor imaging dti measures hippocampus reported people alzheimer disease mild cognitive impairment mci however study date jointly investigated concomitant microstructural volumetric changes hippocampus dementia lewy bodies dlb methods total subjects mci dlb healthy controls recruited multi modal imaging mri dti study included neuropsychological evaluation freesurfer used segment total hippocampus delineate subfields hippocampal segmentations coregistered mean diffusivity fractional anisotropy maps obtained dti images results mci groups showed significantly smaller hippocampal volumes compared dlb controls predominantly subiculum subfields compared controls hippocampal elevated mci dlb characterized volumetric microstructural preservation hippocampus inmci higher hippocampalmdwas associated greater atrophy hippocampus region hippocampal volume stronger predictor memory scores compared within mci group conclusions multi modal integration report novel evidence hippocampus dlb characterized macrostructural microstructural preservation contrary recent suggestions findings support view dti measurements hippocampus superior volumetric changes characterizing group differences particularly mci controls
social deficits core symptom autism spectrum disorder however perturbed neural mechanisms underpinning deficits remain unclear suggested social prediction errors coding discrepancies predicted actual outcome another decisions might play crucial role processing social information gyral surface anterior cingulate cortex signalled social prediction errors typically developing individuals crucial social signal altered individuals autism spectrum disorder importantly degree social prediction error signalling aberrant correlated diagnostic measures social deficits effective connectivity analyses revealed typically developing individuals autism spectrum disorder magnitude social prediction errors driven input ventromedial prefrontal cortex data provide novel insight neural substrates underlying autism spectrum disorder social symptom severity research gyral surface anterior cingulate cortex ventromedial prefrontal cortex could provide targeted therapies help ameliorate social deficits autism spectrum disorder
present easy use sequence search tool antimicrobial resistance sstar combines locally executed blastn search customizable database intuitive graphical user interface identifying antimicrobial resistance genes genomic data although database initially populated public repository acquired resistance determinants arg annot customized particular pathogen groups resistance mechanisms instance outer membrane porin sequences associated carbapenem resistance phenotypes added known intrinsic mechanisms included unique tool ability easily detect putative new alleles truncated versions existing genes variants potential new alleles brought attention user investigation instance sstar able identify modified truncated versions porins may great importance carbapenemase negative carbapenem resistant enterobacteriaceae sstar written java therefore platform independent compatible windows unix operating systems sstar manual includes simple installation guide freely available https github com tomdeman bio sequence search tool antimicrobial resistance sstar importance whole genome sequencing wgs quickly becoming routine method identifying genes associated antimicrobial resistance however many microbiologists use analysis wgs data present substantial challenge developed sstar software graphical user interface enables identification known genes wgs unique capacity easily detect new variants known genes including truncated protein variants current software solutions notify user genes truncated therefore likely nonfunctional makes phenotype predictions less accurate sstar users apply database interest reference comparator manually add genes impact resistance even genes resistance determinants per porins efflux pumps
nursing homes lack information technology supporting clinical work spite potential improve safety quality efficiency nursing home care united states increased attention medical error concern patient safety prompted general recommendations develop sophisticated technologies support clinical decision making point care promote data standards electronic records develop systems communicate however little known applications best support communication risk assessment practices improve resident outcomes nursing homes thus overall aim study evaluate differences sophistication nursing homes impact communication use technology related skin care pressure ulcers used mixed method approach conduct case studies two nursing homes one high sophistication one low sophistication observational analysis social network analysis used identify patterns communication types locations also focus groups conducted explore communication strategies used certified nursing assistants cnas support pressure ulcer prevention practices overall results social network analysis observational data indicate direct interactions cnas registered nurses rns licensed practical nurses lpns frequent low sophistication home occurred centralized locations nursing station compared high sophistication home moreover findings supported focus group results indicate high sophistication home robust integrated communication strategies non may allow interactions throughout facility require less frequent face face interactions cnas rns lpns verify orders report patient status results study provide insight design assessment different forms communication support clinical work nhs relevance industry nurses bear great burdens nursing home care yet issues persist poor quality variable performance caregiving lack implementation proven care interventions one new hope improvement nursing home care introduction improve communication clinical decision making quality care elsevier rights reserved
meta analytic procedures used test effects violent video games aggressive behavior aggressive cognition aggressive affect physiological arousal empathy desensitization prosocial behavior unique features meta analytic review include restrictive methodological quality inclusion criteria past meta analyses cross cultural comparisons longitudinal studies outcomes except physiological arousal conservative statistical controls multiple moderator analyses sensitivity analyses social cognitive models cultural differences japan western countries used generate theory based predictions meta analyses yielded significant effects outcome variables pattern results different outcomes research designs experimental cross sectional longitudinal fit theoretical predictions well evidence strongly suggests exposure violent video games causal risk factor increased aggressive behavior aggressive cognition aggressive affect decreased empathy prosocial behavior moderator analyses revealed significant research design effects weak evidence cultural differences susceptibility type measurement effects evidence sex differences susceptibility results various sensitivity analyses revealed effects robust little evidence selection publication bias
colons harbor trillions microbes including prominent archaeon methanobrevibacter smithii examine contributions archaea digestive health colonized germ free mice bacteroides thetaiotaomicron adaptive bacterial forager polysaccharides consume without smithii sulfate reducing bacterium desulfovibrio piger whole genome transcriptional profiling thetaiotaomicron combined mass spectrometry revealed unlike piger smithii directs thetaiotaomicron focus fermentation dietary fructans acetate whereas thetaiotaomicron derived formate used smithii methanogenesis thetaiotaomicron smithii cocolonization produces significant increase host adiposity compared monoassociated thetaiotaomicron piger biassociated animals findings demonstrate link archaeon prioritized bacterial utilization polysaccharides commonly encountered modern diets host energy balance
resveratrol known inhibit cellular melanin synthesis multiple mechanisms glycolic acid used skin care products excellent skin penetration purpose study examine anti melanogenic effects resveratryl triglycolate rtg novel hybrid compound resveratrol comparison resveratrol resveratryl triacetate rta arbutin resveratrol rtg rta inhibited catalytic activity human tyrosinase tyr potently arbutin cytotoxic anti melanogenic effects examined using murine melanoma cells human epidermal melanocytes hems cytotoxicity rtg similar resveratrol rta rtg decreased melanin levels cellular tyr activities alpha melanocyte stimulating hormone stimulated cells tyrosine stimulated hems rtg also suppressed mrna protein expression tyr tyrosinase related protein dihydroxyphenylalanine chrome tautomerase microphthalmia associated transcription factor mitf hems stimulated tyrosine study suggests like resveratrol rta rtg attenuate cellular melanin synthesis effectively suppression mitf dependent expression melanogenic enzymes inhibition catalytic activity tyr enzyme rtg therefore potential use cosmeceutical ingredient skin whitening
purposethe purpose study assess positive predictive value ppv relative medical chart review international classification diseases icd diagnostic codes identifying opioid overdoses poisonings methodsdata obtained kaiser permanente northwest northern california diagnostic data electronic health records submitted claims state death records oregon washington california linked individual opioid related poisoning codes adverse effects opioids codes combined diagnoses possibly indicative overdoses respiratory depression evaluated comparison chart audits resultsopioid adverse effects codes low ppv detect overdoses assessed charts pursued instead opioid poisoning codes assessed individuals codes present electronic health records period years available information excluded potentially anesthesia related among remaining individuals opioid poisoning codes events accurately identified opioid overdoses miscodes misidentified opioid adverse effects overdoses thus ppv opioid adverse effects overdoses accurately identified events conclusionsopioid poisoning codes predictive value identify opioid overdoses suggesting icd opioid poisoning codes used monitor overdose rates evaluate interventions reduce overdose research assess sensitivity specificity negative predictive value ongoing copyright john wiley sons ltd
today smart mobile devices telephones tablets commonly used due powerful hardware useful features according emarketer report billion smartphone users excluding users tablets world predicted number rise billion thought devices used successfully biomedical applications wireless blood pressure measuring device used together smart mobile device developed study means interface developed smart mobile devices android ios operating systems smart mobile device used indicator control device cuff communicating device bluetooth designed measure blood pressure via arm digital filter used cuff instead traditional analog signal processing filtering circuit newly developed blood pressure measuring device tested patients healthy individuals different ages physician supervision test results compared measurements made using sphygmomanometer shown average accuracy sick individuals accuracy healthy individuals could achieved new device elsevier ireland ltd rights reserved
paper describe control electronics industrial test system based low cost plc developed system hydraulic pulse system generates series high pressure hydraulic pulses max bar based pneumatic hydraulic circuits describe requirements overall concept embedded control system user interface security features network connectivity description software solution describe implementation hierarchical ordered program threads multithreaded program main control state machine conclusion describe calibration method system calibration curves present schematic diagram photo functional prototype system
children early emerging intuitive theories specialized different conceptual domains recently attention turned children concepts social groups finding children believe many social groups mark uniquely social information allegiances obligations another critical component intuitive theories causal beliefs underlie category membership received less attention propose children believe membership groups constituted mutual intentions group members including individual intend individual member group members including individual common knowledge intentions children broad age range applied mutual intentional framework newly encountered social groups early development experiment deploy mutual intentional framework selectively withholding essentialized social categories gender experiment mutual intentionality appears vital aspect children naive sociology elsevier rights reserved
direct gaze salient nonverbal signal social interest intention communicate particular duration another direct gaze modulate perception social meaning gaze cues however poor eye contact deficits social cognitive processing gaze specific diagnostic features autism therefore investigating neuralmechanisms gaze may provide key insights neural mechanisms related autistic symptoms employing functional magnetic resonance imaging fmri parametric design investigated neural correlates influence gaze direction gaze duration person perception individuals high functioning autism hfa matched control group purpose dynamically animated faces virtual characters displaying averted direct gaze different durations evaluated four point likeability scale behavioral results revealed hfa participants showed significant difference likeability ratings depending gaze duration control group rated virtual characters increasingly likeable increasing gaze duration neural level direct gaze increasing direct gaze duration recruit regions social neural network snn control participants indicating processing social salience perceived communicative intent participants hfa however regions social neural network engaged averted decreasing amounts gaze neural response processing direct gaze hfa suggestive social information processing authors published elsevier inc open access license
type interferon ifn system recently suggested play important essential roles pathogenesis myositis however clarification type ifns could function triggering factor pathogenesis myositis yet failed activation type ifn system host defense peptide carries numerous immunomodulatory properties implicated pathogenesis several autoimmune diseases including systemic lupus erythematosus sle expression regulated various endogenous factors including active form vitamin aim study explore potential role relation type ifn system patients polymyositis dermatomyositis compare sle patients healthy controls investigated muscle symptomatic non symptomatic skin biopsies patients short disease duration muscle biopsies patients long disease duration six sle patients symptomatic non symptomatic skin five muscle six skin biopsies healthy individuals served controls tissue specimens immunohistochemically stained neutrophils cdb plasmacytoid dendritic cells bdca myxovirus resistance protein mxa macrophages cdg addition cdb double staining also performed serum levels investigated patients short disease duration healthy controls found expression bdca major producer type ifns mxa interferon inducible protein macrophages higher muscle tissue patients compared healthy controls expression mainly derived neutrophils neutrophils increased symptomatic non symptomatic skin myositis sle patients bdca increased symptomatic skin compared healthy controls moreover expression mxa symptomatic non symptomatic skin sle patients higher compared myositis patients healthy controls difference expression skin myositis sle patients compared healthy controls patients short disease duration low levels compared healthy controls conclusion present study supports hypothesis may activate type ifns could initiate perpetuate inflammatory process prolonged exposure immune system type ifns may eventually break tolerance lead autoimmune myositis elsevier ltd rights reserved
objective understand social care networks children discharged neonatal intensive care unit methods qualitative study conducted home six families seven children data collection authors used triangulation techniques thematic content analysis results family composition nuclear social networks formed support family leisure spiritual ties school hospital institutions families reported challenges caring premature baby main care demands respiratory motor cognitive non effective communication professionals family showed negative impact hospitalization home care conclusion social care networks children discharged neonatal intensive care unit proved disjointed health care children family proved fragmented
paper contains brief description icsitee achievements field power equipment steam boilers steam turbines expansion turbines intended apply thermal power gas pressure resulting flows order produce either mechanical power air blower drive electrical power electrical generator drive equipment applicable romania metal working industry town administration
purpose mass media play important role socialization youth given expanding nature accessibility internet may forefront education however extent internet impact adolescent sexual attitudes behaviors yet known methods total adolescents completed anonymous survey health center new york city cross sectional survey assessed internet accessibility exposure sexually explicit web sites sews sexual behaviors sexually permissive attitudes results participants internet access reported ever visiting sew logistic regression analyses revealed adolescents exposed sews likely multiple lifetime sexual partners one sexual partner last months used alcohol substances last sexual encounter engaged anal sex adolescents visit sews display higher sexual permissiveness scores compared never exposed indicating permissive attitude conclusions exposure internet pornography potential implications adolescent sexual relationships number partners substance use sews serve educational purpose create opportunity adults engage adolescents discussions sexual health consumption internet material longitudinal research needed evaluate exposure sews influences youth attitudes sexual behaviors society adolescent medicine rights reserved
oleuropein well known olive polyphenol shown mediate neuroprotection alzheimer disease cerebral ischemia investigated effects oleuropein pentylenetetrazole ptz induced seizures male nmri mice diazepam standard drug also examined possible involvement opioidergic nitrergic pathways probable effects oleuropein intraperitoneal administration different doses oleuropein significantly increased seizure threshold min prior induction seizure dose dependent manner administration naltrexone opioid receptor antagonist completely reversed anticonvulsant effects oleuropein hand anticonvulsant effect oleuropein blocked non effective dose nonspecific inhibitor nitric oxide synthase nos name selective inhibitor neuronal nos nitroindazole however nitric oxide precursor arginine potentiated anticonvulsant activity oleuropein selective inducible nos inhibitor aminoguanidine change anticonvulsant activity oleuropein seems opioidergic system constitutive neuronal nos may involved anticonvulsant properties oleuropein
background context compromise pedicle screw purchase concern maintaining rigid spinal fixation especially osteoporosis little consistency exists among various tapping techniques pedicle screws often prepared taps smaller diameter exacerbate inconsistency purpose objective study determine whether mismatch tap thread depth thread pitch screw affects fixation tapping osteoporotic bone study design study polyurethane foam block biomechanical analysis materials methods foam block osteoporotic bone model used compare pullout strength pedicle screws nominal diameter tap varying blocks sorted seven groups probe tap tap tap tap tap tap pedicle screw diameter length inserted depth axial pullout testing performed rate min blocks group results significant difference noted groups axial pullout testing mode failure probe group block fracture occurring cases among six groups one screw failed block fracture failed screw pullout conclusions osteoporotic bone model changing tap statistically significant effect axial pullout osteoporotic bone might render tap features marginal findings indicate changing characteristics tap help pullout strength osteoporotic model high rate fracture probe group might imply potential benefit tapping prevent catastrophic failure bone elsevier inc rights reserved
excessive motion makes magnetic resonance imaging mri extremely challenging among children autism spectrum disorder asd medical risks sedation establish need behavioral interventions promote motion control among children asd undergoing mri scans present series experiments aimed establishing tolerance mri environment level motion control would compatible successful mri study evaluated effects prompting contingent reinforcement compliance sequence successive approximations mri using mock mri study used prompting progressive differential reinforcement behaviors dro promote motion control mock mri increasing periods time finally study participants underwent real mri scan detailed session motion analysis informed quality images captured
article presents use transdiagnostic emotion focused treatment young woman nonsuicidal self injury nssi social anxiety disorder generalized anxiety disorder patient also presented subclinical depressive posttraumatic stress eating disorder symptoms unified protocol transdiagnostic treatment emotional disorders barlow cognitive behavioral intervention designed applicable across anxiety depressive related disorders strong emotional components used address range laura presenting concerns individual treatment sessions laura experienced significant reductions nssi urges engage nssi well observable improvements self reported ability respond adaptively intense emotion also reported moderate reductions anxiety disorder symptoms case illustration demonstrates short term transdiagnostic treatment approach flexibly applied variety problems maintained aversive avoidant reactions intense emotion wiley periodicals inc
construction industry experiencing changes tools techniques used planning high productivity safety sustainability changes seen much preconstruction planning pcp stage pcp highly individualistic nature planners contractors use past experience plan project within constraints time cost quality use planning techniques pcp stage subject research development implementation long time however present importance placed use different tools tools like knowledge based systems computer graphics combination two reported literature literature also suggests use geographic information systems gis recent tool pcp stage structure developed becomes important component neighborhood closely related existing facilities surroundings hence construction planned isolation reference locality existing facilities utilities topography pcp stage consideration given surroundings use gis found helpful therefore primary objective present study explore potential application areas gis tool pcp stage present study informs practitioners construction industry application areas gis wider use real life projects finally research areas worthy investigation highlighted american society civil engineers
background struma ovarii literally goitre ovary rare form monodermal teratoma comprises either entirely predominantly thyroid tissue also includes cases mature teratoma less thyroid tissue harboring thyroid associated malignancy study investigate biological feature immunohistochemical features struma ovarii patients methods retrospective study enrolled patients struma ovarii including case papillary thyroid carcinoma cases benign struma ovarii results median age ranged concurrent primary ovarian lesions cases ipsilateral mucinous cystadenoma cases ipsilateral cystic teratomas one case ipsilateral mature cyst teratoma whereas one case contralateral brenner tumor ascitic fluids observed four cases hydrothorax fluids observed two cases nine cases found chance routine physical examination common clinical manifestations lower abdominal discomfort palpable mass menorrhagia acute hypogastralgia congenital ovarian cysts torsion cough polypnea elevated found four cases tumors cases totally intact encapsulation tumor size ranged average greatest dimension twenty multilocular four unilocular cystic masses typically filled light yellow brown amber gelationous tissue clear green yellow fluid microscopically tumors consisted thyroid follicular structure lined flatcuboidal cells filled eosinophilic colloid like material one case epithelium cells exhibited malignant transformation classified follicular variant papillary carcinoma furthermore endometrial polyps found two cases one post menopause two cases initially misdiagnosed ovarian tumors intraoperative frozen section immunohistochemical stains thyroglobulin thyroid peroxidase positive thirteen patients cured without relapse one patient lost follow conclusions struma ovarii rare tumor highly specialized form monodermal ovarian teratoma peak incidence fifth decade life struma ovarii may manifest variant pathologic features presenting thyroid gland diagnosed histological basis thyroid carcinoma immunohistochemical staining thyroglobulin thyroid peroxidase contributed diagnosis disease principle clinical treatment malignant struma ovarii commonly derived experience thyroid carcinoma postoperative adjuvant radiation therapy chemotherapy may recommended perform prognosis generally favorable
background aims subset patients inflammatory bowel diseases ibd continuously active inflammation leading high number complications high direct health care costs diagnostic tests medications surgeries indirect costs reduced employment productivity fewer opportunities activities identifying high risk patients providing effective interventions could produce better outcomes reduce costs used prior year data create ibd risk models predict ibd related hospitalizations emergency department visits high treatment charges year subsequent year methods performed retrospective study medical records patients ibd treated university michigan hospital fiscal years selected clinical variables prior year tested abilities predict adverse outcomes ibd related hospitalizations emergency department visits treatment charges year subsequent year individual patients included data set created multivariate model based randomly selected cohort patients validated model patients logistic regression used bivariate multivariate analyses results factors predicted high cost outcomes included presence psychiatric illness use corticosteroids use narcotics low levels hemoglobin high numbers ibd related hospitalizations validation cohort model predicted ibd related hospitalizations emergency department visits high charges following year receiver operating characteristic curve values respectively conclusions identified factors effectively identify patients ibd high risk hospitalization emergency department visits high treatment charges next year patients closely monitored aggressively managed
electric arc furnace eaf acts source sub synchronous frequencies ssfs electrical network ssfs lead resonance respective matched torsional modes turbine generator shaft excited causing torsional oscillating torques tots amplification may lead gear damage shaft fatigue lifetime reduction severe damages shaft paper presents assessment tots amplification due multiple eaf operations pcc eafs modeled using mathematical model electric arc resistances eafs varied deterministically frequency range comport realistic eaf tots measured without resonant excitation torsional modes eigenvalue analysis fft technique used analyse torsional torques
mechanisms moral disengagement violent video game play recently received considerable attention among communication scholars date however study analyzed prevalence moral disengagement factors violent video games fill research gap present approach includes systematic literature review content analysis moral disengagement cues embedded narratives actual game play top ranked first person shooters findings suggest moral disengagement factors frequently embedded first person shooters prevalence varies considerably violent video games include justifications portrayed violence distorted portrayal consequences dehumanization opponents implications findings research violent games discussed
paper addresses problem preserving nominal performance conventional cascade controller electric motor drives presence parameter uncertainties external disturbances practical reduced order proportional integral observers incorporated predesigned controllers order enhance robust performance current speed controllers unified analysis based singular perturbation theory presented confirm desired approximation augmented system observers nominal closed loop system validity proposed dual observer based control scheme tested via computer simulations experiments using motor system results verify proposed controller used effectively recover nominal performance conventional cascade scheme electric motor drives
fast aging population around world makes ambient intelligence based assistive technologies essential sustainable efficient health care systems aging adults decide live alone home need constant monitoring control health status quality life work introduces new wearable device continuously monitors emotional state elderly electro dermal activity eda used classify aging adults two groups sleepiness stressed results report performance accuracy using exclusively time magnitude features eda events elsevier rights reserved
chronic inflammation caused adaptive immune responses autoimmune allergic conditions driven lymphocyte subset balance treg skewed cellular profiles antigen specific manner however several chronic inflammatory diseases clearly defined adaptive immune mechanisms drive chronicity conditions include affect lung nonatopic asthma idiopathic pulmonary fibrosis comprising significant health problems remodeling extracellular matrix ecm causes organ dysfunction largely generated fibroblasts major cell controlling net ecm potential targets treatment approaches context ecm pathology fibroblast phenotypes contribute ecm inflammatory cell accumulation integrated chronic disease mechanisms including cancer evidence suggests innate cytokine responses may critical nonallergic nonautoimmune disease enable environmental agent exposure mechanisms independent adaptive immunity innate immune cytokines derived macrophage subsets innate lymphoid cell ilc subsets directly regulate fibroblast function also suggest stat activating cytokines sensitize fibroblasts innate cytokine milieu drive phenotypes exacerbate existing adaptive responses review evidence exploring innate cytokine regulation fibroblast behavior
children autism spectrum disorders asd long known deficits performance praxis gestures motor deficits also correlate social communicative deficits date precise nature errors involved praxis clearly mapped based observations individuals asd performing gestures hypothesized simultaneous execution multiple movement elements especially impaired affected children examined school aged participants asd age matched controls performing seven simultaneous gestures required concurrent performance movement elements nine serial gestures elements performed serially indeed group gesture type interaction whereas groups greater difficulty performing simultaneous serial gestures children asd times greater performance decrement simultaneous serial gestures controls results point potential deficit simultaneous processing multiple inputs outputs asd deficits could relate models social interaction highlight parallel processing nature social communication autism res international society autism research wiley periodicals inc autism res international society autism research wiley periodicals inc
modeling used computer graphics various fields since growth gestures virtual reality embodied cognition various new technologies developed either improve modeling efficiency provide nature intuitive experience users paper user experience perspective try compare methods navigation objects virtual modeling environment including simple bare hand gestures tangible user interfaces tui object hand well mouse keyboard primary input based embodied cognition theory hypothesis object hand method might bring better user experience since interaction object hand enhance user cognition navigating model present conceptual design two approaches three design models demonstrate differences user interaction modeling software
background patients chronic hepatitis hcv infection high prevalence vitamin deficiency genomewide association study data showed several genetic variants within vitamin cascade affect vitamin function study aimed determine whether genetic polymorphisms genes vitamin pathway associated treatment responses pegylated interferon peg ifn based therapy patients chronic hcv infection methods study included thai patients university hospitals diagnosed chronic hcv infection treated peg ifn ribavirin patients genotyped functional variants vitamin synthetic pathway including cypr cypb dhcr pre treatment predictors sustained virologic response svr weeks following discontinuation therapy identified using logistic regression analysis results svr achieved patients hcv genotype hcv non genotype hcv genotype infected patients variant dhcr locus significantly associated svr hcv genotype patients dhcr higher rate svr allele hcv non genotype infected patients svr rate differ two groups allele multivariate analysis liver fibrosis stage dhcr allele independent pre treatment predictors svr following peg ifn based therapy hcv genotype patients baseline hcv rna independent predictor svr hcv non genotype patients polymorphisms cypr cypb associated treatment outcome even genotype non genotype hcv infection conclusion dhcr polymorphism may pre treatment predictive marker response peg ifn based therapy chronic hcv genotype infection
production technology highly interdisciplinary field research comprises different production domains cutting welding forming assembly etc industry sectors materials scales moreover production strong interdependencies scientific disciplines product development materials engineering business economics information communication technology social science natural science integrative production technology aims develop deep technology spanning perception offer products matching customer societal demands competitive prices quickly adapt market societal changes assuring constant predictable product properties cluster excellence coe integrative production technology high wage countries initiated special issue present newest results field wider summary results reader may refer recently published book coe brecher zdemir integrative production technology theory applications springer cham
adverse environmental impacts associated high nitrate concentration undesirable due extremely toxicity aquatic species human include also strongly promotion eutrophication different methods developed eliminate water pollution use denitrifying bacteria ideal solution thanks low cost low energy consumption study performed isolation bacteria activated sludge best denitrifying bacteria selected incubated bioreactor containing synthetic wastewater rich nitrate ions griess test zinc powder proved denitrification capacity strain ability complete reduction last stage passing nitrite atmospheric nitrogen gave also reduction percentage significant growth rate finally bacterium tested microscope biochemical gallery
today smartphone operating systems frequently fail provide users adequate control visibility third party applications use private data taintdroid realized android system detect user implicit taint privacy leakage taintdroid inherent defects better detect user implicit taint privacy leakage android platform paper analyzes implicit taint detection proposes automated detection system based dynamic taint tracking called taintchaser monitoring sensitive data taintchaser provides informed use third party applications phone users valuable input smart phone security service firms seeking identify misbehaving applications taintchaser detect behaviors user data leakage android applications fine granularity level system also analyze test massive android software automatic way uses taintchaser automatically analyze popular android applications finds may leak user privacy
paper aims present economic model characterized set axioms consistent laws thermodynamics two new axioms weak disposability weak directional disposability output essentiality introduced satisfy materials balance principle entropy law respectively axiomatic production model compared well known production models account joint production good bad outputs illustrate advantages new modeling approach
efficiency improvement great significance simulation driven antenna design optimization methods based evolutionary algorithms eas two main efficiency enhancement methods exploit data driven surrogate models multi fidelity simulation models assist eas however optimization methods based latter either need hoc low fidelity model setup difficulties handling problems design variables main barrier industrial applications address issue generalized three stage multi fidelity simulation model assisted antenna design optimization framework proposed paper main ideas include introduction novel data mining stage handling discrepancy simulation models different fidelities surrogate model assisted combined global local search stage efficient high fidelity simulation model based optimization framework applied sadea state ofthe art surrogate model assisted antenna design optimization method constructing sadea experimental results indicate sadea successfully handles various discrepancy simulation models considerably outperforms sadea terms computational efficiency ensuring improved design quality society computational design engineering publishing servies elsevier
heterogeneous elastoplastic deformation structural glasses explored using framework random first order transition theory glass transition along extended mode coupling theory includes activated events theory involves coupling continuum elastic theory strain transport mobility generation transport described theory glass aging rejuvenation fluctuations arise generation transport mobility fictive temperature stress treated explicitly examine nonlinear flow glass deformation finite strain rate interplay among fluctuating fields leads spatially heterogeneous dislocation particles glass appearance shear bands type observed metallic glasses deforming mechanical stress
hydro electric barrel turbines used extraction clean energy water flowing velocity sec kinetic energy available flow water converted mechanical energy means barrel helical type projections depressions similar helical milling cutter mechanical energy converted electrical energy means pan type electrical generator output stored battery inverter used specific advantage barrel turbine easy handling environment friendly design thus eliminating need environmental impact assessment studies proposed project consists cad model barrel turbine generated using catia pro softwares analysis cad model performed analysis strength power extraction capabilities shall estimated using ansys fluid dynamics parameters diameter length turbine variation velocity flow shall studied work
pilot study aimed investigate feasibility acceptance effects biofeedback assisted mental training population fifteen year old pupils austrian elementary school participants instructed relaxation techniques using biofeedback intervention weeks active mental training regular instructions teacher time period weeks without instructions attention concentration improved results indicate feasibility good acceptance beneficial effects biofeedback assisted mental techniques austrian elementary school pupils
blockade ifn alpha ifn beta signaling using either antibody selective spr agonist cym prevented type diabetes mouse rip lcmv model first treatment antibody cym limited migration autoimmune anti self cells external boundaries around islets prevented entry islets could positioned engage kill thus remove insulin producing beta cells second cym induced exhaustion signature antiself cells regulating negative immune regulator receptor genes pdcd lag ctla tigit btla thereby limiting killing ability means insulin production preserved glucose regulation maintained mechanism spr immunomodulation described
introduction acquired jak well calreticulin calr mutations involved development philadelphia negative myeloproliferative neoplasms mpn previously showed jak mutation could also found coronary patients patients peripheral arterial disease pad however prevalence calr mutations unknown vascular risk patients evaluation subject present study materials methods determined prevalence calr exon indel mutations cohort angiographied coronary patients including patients pad additionally patients pad without coronary angiography calr mutation analysis performed using pcr fragment analysis jak mutation analysis allele specific real time pcr results included patients individuals tested positive jak mutation calr exon mutations detected patients conclusions conclude calr exon mutations infrequent vascular risk patients routine testing presence calr mutations recommended unselected patients vascular disease future studies warranted define putative pathologic role calr mutations patients without mpn elsevier ltd rights reserved
paper proposes adaptive controller improved high frequency injection method sensorless synchronous reluctance drive systems mathematical model presented show use high frequency injection method takes account effects unequal mutual inductances influence speed reduces rotor position estimation error adaptive speed control algorithm offers improved transient performance comparison typical proportional integral controllers employed sensorless drive systems demonstrate viability proposed adaptive controller modified high frequency injection method implemented using tms digital signal processor control prototype synchronous reluctance motor drive experimental results presented show transient load disturbance tracking responses proposed drive system superior comparison drive uses controller experimental theoretical analyses clearly indicate proposed high frequency injection method adaptive speed loop controller offers improved performance adjustable speed synchronous reluctance drive systems
background various reports published concerning ethical dilemmas nursing midwifery many nurses midwives struggle conflict personal feelings raised abortion duties position studies investigate extent conditions abortion care education registered nurses rns certified nurse midwives cnms japan objectives describe japanese abortion care education programs investigate program directors relevant persons perceptions abortion care education design descriptive study used determine extent abortion care education programs respondents perceptions abortion care education setting japanese nursing midwifery schools invited participate study participants response rate response rate varied program type nursing programs midwifery programs methods confidential survey requesting information curricular coverage ten reproductive health topics related abortion mailed program directors results results show majority cnm programs surveyed offer didactic exposure instruction family planning contraception emergency contraception legal considerations possible medical complications however programs offer clinical exposure topics respondents reported lack time low priority given abortion care education issues curriculum priority educational materials textbooks guidebooks exist abortion care japan educators use general nursing textbooks cover topic conclusion regardless interest intention provide abortion services part practice providers abortion care education need knowledgeable full range reproductive health options including family planning abortion able convey information clients elsevier ltd rights reserved
increasing availability violent video games implication recent school shootings raised volume public debate effects games aggressive behavior related variables article reports experiment designed test key hypotheses concerning short term impact exposure violent video games young women population received relatively little attention research literature results brief exposure violent video game increased aggressive behavior mediational analyses suggested violent video game effect aggression mediated instrumental aggressive motivation partially mediated revenge motivation results suggested violent video game effect aggression might greater game player controls sex violent game character wiley liss inc
optimal design electrical machines important issue automotive industry order reduce cost volume actuator improve performances context use compact machines high power density preferred consequently high speed machines field weakening required addition really optimal design requires dispose sufficiently accurate models main physical phenomena involved electromechanical conversion models need sufficiently fast order suitable optimization process important limitation use internal permanent magnet synchronous machine distributed windings temperatures insides machine especially windings thus internal losses high speed field weakening operation iron losses sensitive flux densities variation iron could really high high electrical frequency linked rotor speed sharp variation flux density waveforms inside iron stator due field weakening operation study electric machine design based first harmonic hypothesis without harmonic currents original mathematical model developed provides fast accurate estimation iron losses particularly field weakening operation even machine supplied sinusoidal currents described paper uses polynomial form iron losses function fundamental electrical frequency take account flux density waveforms yoke teeth use nonlinear iron coefficients linked currents paper present complete method calculating iron coefficients nonlinear magnetic nodal network machine detailed study local flux density waveform harmonic content yoke teeth provided two particular operating points maximal power without field weakening maximal power maximal speed two points require accurate estimation optimal design electrical machine addition local iron coefficients teeth yoke per volume unit provided order study local evolution iron losses field weakening operation show iron losses follow evolution yoke teeth fact flux density distribution teeth sensitive field weakening application model provided calculation iron losses whole operating space specific machine comparison provided fast model finite elements approach international association mathematics computers simulation imacs published elsevier rights reserved
medium voltage power system fault currents subjected uncertainties lines distributed generations uncertainties fault currents power grid introduce system protection problems superconducting cablewith fault current limiting capability used means meet increasing electricity demand resolving issues involving system protection order integrate fault current limiting superconducting cable power grid impedance selection fault conditions needs consider impact power system uncertainties system protection paper expected regret based method proposed determining impedance fault current limiting superconducting cable incorporating uncertainties fault currents results numerical simulations presented show effectiveness proposed expected regret based impedance selection method
applications cmos squaring circuit analog signal processing studied paper circuit based dual translinear loop square law characteristic mos transistor saturation region reconfigurable circuit employed basic analog cell implementation several building blocks including multiplier logarithmic divider exponential function generator circuits proposed solution implamentation analog logarithmic exponential functions easily accessible characteristic cmos technology well integration configurable cell current mode implementation circuits leads straightforward intuitive configurations study performance circuit effects channel length modulation well mismatch threshold voltages thoroughly discussed proposed circuits designed simulated using hspice simulator level parameters bsimv standard cmos technology matlab results validate simulation results obtained hspice
production processes use surfacemount technology smt assembly printed circuit boards automated optical inspection widely employed diagnose component defects however commonly used inspection algorithms hardly meet reliability time efficiency requirements simultaneously especially applied components high density large scale integration ball grid array bga paper novel approach presented inspect bga component defects adaptive thresholding combined modified component segmentation first performed extract grayscale image solder balls line based clustering method proposed recognize ball array simultaneously accurate position orientation bga obtained based recognition results finally ball features extracted diagnose potential defects proposed algorithm implemented host computer samsung smt machine results obtained show proposed approach suitable vast majority bgas different ball arrays also robust interferences caused image segmentation furthermore compared samsung algorithm significant advantages time efficiency high inspection accuracy nonideal lighting conditions
nuclear factor nfi plays pivotal role various cellular processes odontoblast osteoblast differentiation nfic deficient mice showed abnormal tooth bone formation transplantation nfic expressing mouse bone marrow stromal cells rescued impaired bone formation nfic mice studies suggest nfi regulate osteogenesis dentinogenesis concert several factors including transforming growth factor beta kruppel like factor beta catenin review focus function nfi tooth bone formation relevant pathways involve nfi
hybrid solar biomass fluidized bed drying system designed evaluated developed system comprised fluidized bed solar collector biomass furnace solar assisted fluidized bed dryer integrated biomass furnace used investigated drying kinetics paddy average temperature air drying degrees paddy moisture content dried wet basis mass flow rate performance fluidized bed drying system assessed base energy exergy analyses specific energy consumption sec solar fractions biomass fractions thermal exergy efficiencies obtained sec drying times lower hybrid solar biomass fluidized bed drying system compared solar dryers elsevier ltd rights reserved
cell pack tested need low ripple charging current ensure tester accuracy necessary set proper filter excellent filtering characteristic wide input output range inner resistance cell pack small system indefinite filter designed type traditional matched filter flat fading would inevitably occur would reduce power transmission efficiency paper discussed design philosophy non matched filter proposed non matched chebyshev filter design method aimed special resistive capacitive property cell pack method proved correct feasible simulation
mental health services throughout world currently regard evidence based psychological treatments best practice treatment mental disorders aim study analyze evidence based treatments drawn rcts reviews meta analyses guides lists provided national institute health care excellence nice division clinical psychology american psychological association apa cochrane australian psychological society aps relation mental disorders adults total treatments analyzed mental disorders compared determine level agreement among organizations results indicate cases little agreement among organizations several discrepancies within certain disorders results require reflection meaning attributed evidence based practice regard psychological treatments possible reasons differences discussed based findings proposals unify criteria reconcile realities clinical practice scientific perspective analyzed
part year longitudinal study sixth grade students completed engineering based problem earthquakes involving integrated stem learning students employed engineering design processes stem disciplinary knowledge plan sketch construct building designed withstand earthquake damage taking account number constraints testing students redesigned build improved structure using framework design processes report students capabilities planning creating annotated sketches transforming models understanding core stem concepts apparent responses including shape properties stability rigidity balance strength engineering techniques group problem solving involved moving iteratively design phases frequently revisiting problem scoping cognizant problem goal boundaries constraints appreciating design sketches guiding constructions students also observed consider number problem components simultaneously indicating capabilities handling complexity task
introduction deleterious effects letrozole aromatase inhibitor used adjuvant treatment breast cancer postmenopausal women bone well documented represent major drawback clinical use raloxifene selective estrogen receptor modulator clinically approved anti osteoporotic drug recently demonstrated efficacious women breast cancer present study evaluated effects preventive curative treatment raloxifene letrozole induced alterations bone microarchitecture turnover markers chemically induced menopause model mice method swiss strain albino female mice made menopausal inducing ovotoxicity using vinyl cyclohexene epoxide vcd days followed days drug free period confirmed ovarian histology serum estradiol levels effects femoral lumbar bones evaluated micro determination bone volume trabecular number separation thickness connective density trabecular pattern factor bone turnover markers including alp trapb hydroxyproline rankl addition markers wnt signaling sclerostin dickkopf also evaluated rule involvement pharmacokinetic interaction plasma levels letrozole raloxifene measured following drugs alone combination results though bone loss observed vcd treated mice indicated micro measurements enhanced letrozole administration one month particularly epiphysis femoral bones raloxifene whether administered concurrently post letrozole able revert structural alterations changes turnover markers caused letrozole varying degrees estrogen deficiency following letrozole treatment ovotoxic mice associated significant increase sclerostin dickkopf lumbar femur bones attenuated preventive curative treatment raloxifene plasma levels letrozole remained unaffected raloxifene administration vice versa conclusions study indicates potential raloxifene preventing attenuating letrozoleinduced bone loss effects found independent pharmacokinetic interaction two drugs elsevier ireland ltd rights reserved
detection correction document skew one important document image analysis steps icdar document image skew estimation contest disec first contest dedicated record recent advances field skew estimation using well established evaluation performance measures variety printed document images benchmarking dataset used contains images obtained various sources newspapers scientific books dictionaries document images contain figures tables diagrams architectural plans electrical circuits written various languages english chinese greek paper describes details contest including evaluation measures used well performance twelve methods submitted ten different groups along short description method
recycling post consumer pet postc pet technology cross disciplinary practice many fields science involved include polymer chemistry physics process engineering manufacturing engineering paper presents concise background current state knowledge respect postc pet recycling covering disciplines mentioned first section paper brief background presented virgin pet synthesis thermal transitions processing applications second section covers pet recycling process focus contamination ways increase molecular weight recycled pet pet serves introduction section chain extension process described detail section current understanding chain extenders chain extension experimentation variables equipment reviewed reactive extrusion process described section special focus system stability chain extension conditions section covers effect chain extension pet thermal transitions crystallinity section presents injection stretch blow moulding isbm process possible application pet focus preform bottle moulding last section gives description technology detect bottles orientation conformation changes elsevier ltd rights reserved
histoenzymic studies sublingual salivary gland buffalo foetuses ranging cvrl days cvrl full term conducted foetuses categorized three groups based curved crown rump length cvrl cvrl days weak activity phosphatases oxidoreductases observed acinar cells ductular epithelium cvrl days weak moderate diffused granular alkaline phosphatase akpase activity observed mucous acini whereas oxidoreductases showed moderate activity enzyme activity progressively increased advancement gestation period akpase activity lumen acini along intercellular canaliculi cvrl days full term large ducts exhibited strong activity oxidoreductases indicating increased metabolic activity cells
sleep problems pregnancy impair maternal health increase risk adverse pregnancy outcome circadian preference toward eveningness associated sleep problems previous studies studied whether evening type women sleep problems pregnancy compared chronotypes sample consisting pregnant women finnish child sleep birth cohort chronotype assessed shortened version morningness eveningness questionnaire pregnant evening type women reported sleep problems including troubles falling asleep poor sleep quality daily tiredness morning type women even controlling sleep duration sleep deprivation higher scores epworth sleepiness scale basic nordic sleep questionnaire global seasonality score also often smokers also pregnancy reported poorer general health morning type women also reported sleep problems childhood adolescence morning type women results indicate eveningness associated sleep problems unhealthy life habits pregnancy
designing developing scale selection mechanisms generating hypotheses characteristic scales signals essential selected scale levels reflect extent underlying structures signal paper presents theory depth theoretical analysis scale selection properties methods automatically selecting local temporal scales time dependent signals based local extrema temporal scales scale normalized temporal derivative responses specifically paper develops novel theoretical framework performing temporal scale selection time causal time recursive temporal domain necessary processing continuous video audio streams real time modelling biological perception recently developed time causal time recursive scale space concept defined convolution scale invariant limit kernel show possible transfer large number desirable scale selection properties hold gaussian scale space concept non causal temporal domain temporal scale space concept truly time causal domain specifically show temporal scale space concept possible achieve true temporal scale invariance although temporal scale levels discrete novel theoretical construction analysis starts detailed comparison different temporal scale space concepts relative advantages disadvantages leading focus class recently extended time causal time recursive temporal scale space concepts based first order integrators equivalently truncated exponential kernels coupled cascade specifically discrete nature temporal scale levels class time causal scale space concepts study two special cases distributing intermediate temporal scale levels using either uniform distribution terms variance composed temporal scale space kernel logarithmic distribution case uniform distribution temporal scale levels show scale selection based local extrema scale normalized derivatives temporal scales makes possible estimate temporal duration sparse local features defined terms temporal extrema first second order temporal derivative responses dense features modelled sine wave lack temporal scale invariance however constitute major limitation handling dense temporal structures different temporal duration uniform manner case logarithmic distribution temporal scale levels specifically taken limit time causal limit kernel infinitely dense distribution temporal scale levels towards zero temporal scale show possible achieve true temporal scale invariance handle dense features modelled sine wave uniform manner different temporal durations temporal structures well achieve general temporal scale invariance signal temporal scaling transformation scaling factor integer power distribution parameter time causal limit kernel shown temporal scale selection properties developed pure temporal domain carry feature detectors defined time causal spatio temporal spectro temporal domains
objective considering limited data available natural course euthyroidism study designed evaluate progression time euthyroidism subclinical overt hypo hyperthyroidism methods study conducted within framework tehran thyroid cohort study individuals aged years followed six years overall loss follow rate applying exclusion criteria data euthyroid subjects remained analysis six year natural course analysis thyroid function tests clinical characteristics metabolic characteristics assessed baseline every three years results annual incidence rates confidence intervals subclinical overt hypothyroidism per persons respectively thyroid hyperfunction annual incidence rates subclinical overt hyperthyroidism per persons respectively euthyroid persistency years predictive factors conversion thyroid dysfunction thyrotropin free thyroxine thyroid peroxidase antibody levels sex smoking criteria early diagnosis hypothyroidism sensitivity specificity obtained based baseline three year follow ups thyroid function tests thyroid peroxidase antibody early diagnosis hypothyroidism significantly associated impaired glucose tolerance relative risk high cholesterol relative risk obesity relative risk hypertension relative risk conclusion study shows six year follow iodine sufficient area euthyroid subjects found progress thyroid dysfunction particular subclinical hypothyroidism
microct imaging allows noninvasive microstructural evaluation mineralized bone tissue essential studies small animal models bone joint diseases automatic segmentation evaluation articular surfaces challenging present novel method create knee joint surface models evaluation ptoa related joint changes rat using atlas based diffeomorphic registration automatically isolate bone surrounding tissues validation two independent raters manually segment datasets resulting segmentations compared novel automatic segmentation process data evaluated using label map volumes overlapmetrics euclidean distance mapping time trial intraclass correlation coefficients calculated compare methods greater total overlap union overlap mean overlap calculated compare automatic manual methods ranged euclidean distance comparison also performed showed measurable difference manual automatic segmentations furthermore new method times faster manual segmentation overall study describes reliable accurate automatic segmentation method mineralized knee structures microct images allow efficient assessment bony changes small animal models ptoa
optimized design smart post buckled beam actuator pba performed study smart material based piezoceramic stack actuator used prime mover drive buckled beam actuator piezoceramic actuators high force small displacement devices possess high energy density high bandwidth study bench top experiments conducted investigate angular tip deflections due pba new design linear tolinear motion amplification device developed circumvent small displacement handicap piezoceramic stack actuators enhances piezoceramic actuator mechanical leverage factor four pba model based dynamic elastic stability analyzed using mathieu hill equation formal optimization carried using newly developed meta heuristic nature inspired algorithm named bat algorithm utilizes echolocation capability bats optimized pba conjunction generates end rotations order degrees output end optimized pba design incurs less weight induces large end rotations useful development various mechanical aerospace devices helicopter trailing edge flaps micro nano aerial vehicles robotic systems
paper low power low output ripple regulator designed teaching learning based optimization tlbo radio frequency identification applications order decrease power consumption voltage regulator sub blocks supplied elementary stages proposed operational amplifier employed regulator adaptive biasing used bandgap reference regulator totally designed mosfet optimize proposed regulator modeling regulator help neural network tlbo algorithm used outputs tlbo output voltage ripple value power consumption using algorithm output voltage ripple power consumption also quiescent current design decreased chip area layout design cadence software operation frequency circuit mhz simulation done cmos technology
minimum energy control problem fractional positive electrical circuits bounded inputs formulated solved sufficient conditions existence solution problem established procedure solving problem proposed illustrated example fractional positive electrical circuit
classroom observation important part language teacher education kelly grenfell effects could enhanced observation guided analysis video recorded lessons matter fact focus teacher talk specific conversational patterns sinclair sinclair brazil could great benefit teacher education moreover digital data audio video text presenting natural speech context would relevant tool teacher trainers order help trainees develop teaching awareness interaction ability especially data easily freely accessible properly treated new methods computer based multimodal analysis study analysed multimodal approach teacher talk questioning several italian classrooms questioning one common techniques used teachers richards serves principal way teachers control classroom interaction classrooms half class time taken question answer exchanges richards focused two main types questions display questions referential questions usage video recorded lessons transcribed subtitled investigated presence relevance non linguistic patterns match regularity linguistic phenomena particularly examined specific non verbal para verbal activities made speakers tightly linked various types questions noted recurring behaviours used together mentioned linguistic structures express specific communicative didactic scopes functions say build spread knowledge italian classroom
introduction irritable bowel syndrome ibs common condition clinical practice currently objective tests rule disease rather tests rule diseases biomarkers ibs may provide tools needed diagnosis prognosis therapy include identification differences microbial composition immune activation bile acid composition colonic transit alteration sensation subgroups ibs patients areas covered studies included review chosen based pubmed search biomarkers ibs reviewed literature biomarkers appraise accuracy validity whether actionable covered genetic associations biomarkers review expert commentary significant promise usefulness biomarkers ibs promising actionable biomarkers markers changes bile acid balance elevated bile acid stool altered colonic transit however also potential microbial studies mucosal proteases future actionable biomarkers
efficient operation reservoirs relies effective release water flooding requiring good understanding spillways hydraulics series experiments conducted laboratory flume stepped spillway model moderate slope discharges using regular uniform horizontal steps height several new step configurations including inclined horizontal curved steps without reflector blocks flow patterns investigated energy losses horizontal stepped spillway compared obtained number similar previous studies results obtained new step configurations good agreement shown previous results horizontal steps inclined horizontal curved steps dissipated twice much energy horizontal steps results highlight importance considering variety step forms spillway design flows unpredictable energy dissipation important
introduction avulsion fractures anterior inferior iliac spine aiis anterior superior iliac spine asis tuberositas ischii iliac apophysis reflected head rectus occur children apophyseal cartilage failure report present two cases avulsion fractures aiis tuberositas ischii case report two amateur football players years old presented emergency clinic groin pain kicking ball football match passive hip motions normal whereas active hip motions painful right groins painful deep palpation radiological examinations revealed avulsion fracture aiis one patient avulsion fracture tuber ischium patient started analgesic treatment patients lying supine position hip degree flexion patients mobilized weeks elbow crutches four weeks later started active hip motions conclusion avulsion fractures asis tuber ischiadicum rare cases adolescent sportsmen injuries easily overlooked misdiagnosed delay diagnosis may cause hip pain lower performance sportsmen
weight gain primary treatment goal anorexia nervosa however little known heterogeneity weight gain pattern treatment preliminary evidence suggests weight gain trajectory associated treatment outcome study grouped patients using mixture modeling weight gain trajectories compared predictors treatment outcomes trajectory groups women diagnosed subthreshold completed self report measures admission six months discharge integrated inpatient partial hospitalization behavioral specialty eating disorders program gowned weights measured daily three distinct trajectories emerged negative quadratic optimal negative quadratic fast weight gain fast positive linear slower weight gain slow majority patients assigned optimal group trajectory groups differed admission discharge follow variables fast group emerged distinct women group twice likely binge vomit regularly compared two groups likely achieve weight restoration discharge positive weight outcomes short term follow group differences eating disorder behavioral frequencies follow adjusting behavioral severity admission weight gain trajectory may serve personalized treatment marker outcome could inform research moderators mediators treatment response randomized controlled treatment studies utilizing weight gain trajectories determine group membership may help identify subgroups patients differential responses treatment interventions
widely accepted postnatal development trabecular bone adapts prevailing loading environment via modelling however little known mechanisms whether predominantly modelling remodelling controls whether loading influences development fetal bone growth order make inferences factors assessed pattern fetal trabecular development humerus femur via histomorphometric parameter quantification growth development months prenatal trabecular architecture thickness number bone volume fraction compared across upper lower limb bones proximal distal regions sexes data presented indicate prenatal development trabeculae became thicker less numerous whilst bone volume fraction remained constant partly mimics pattern early postnatal development years described researchers thickness reported increase whilst number reduced bone volume fraction decreased perhaps balance bone modelling deposition resorption changes post partum published histological data suggest bone deposition slows birth resorption rates remain constant hence fetal development may characterized relatively high rates modelling particularly bone deposition comparison postnatal respect measures thickness number bone volume fraction prenatal development bone site sex specific whilst postnatally measures architecture diverge despite reported developmental variation frequency speed amplitude fetal movements begin weeks continue birth probably therefore loading induced muscular contractions may prenatal limb bone micro architecture follows generalised predetermined growth trajectory genetic blueprint appears case gross distribution trabecular tissue
bold step forward approach severe enduring anorexia nervosa invites new paradigms research practice provides opportunity explore fault lines communities practice social structures inform paper serves question medical metaphors treatment based favour alternative perspectives resonate clearly lived experience failed invite consideration alternative metaphors disrupt notion heroic patients therapists mediate acts self silencing sensitising radical acts listening beyond randomised trials manuals time listen realities suffering minutiae resistance life still lived
social perception social reality jussim reviews evidence social psychology related fields reaches three conclusions although errors biases self fulfilling prophecies person perception real reliable occasionally quite powerful average tend weak fragile fleeting perceptions individuals groups tend least moderately often highly accurate conclusions based research error bias self fulfilling prophecies routinely greatly overstate power pervasiveness consistently ignore evidence accuracy agreement rationality social perception weight evidence including classic research widely interpreted testifying power biased self fulfilling processes interpersonal expectations relate social reality primarily reflect rather cause social reality case teacher expectations also social stereotypes perceptions groups bases expectations regarding individuals time long overdue replace cherry picked unjustified stories emphasizing error bias power self fulfilling prophecies inaccuracy stereotypes conclusions closely correspond full range empirical findings includes multiple failed replications classic expectancy studies metaanalyses consistently demonstrating small best moderate expectancy effects high accuracy social perception
water clarity trends three upper great lakes lakes superior michigan huron assessed via satellite imagery light attenuation coefficients seawifs aqua modis satellites compared favorably situ measurements significant temporal spatial trends differences noted within three lakes lake wide average lake superior exhibit changes annual values lake huron however showed significant negative trend study period using seawifs modis datasets similarly annual values lake michigan declined offshore waters depth northern lake michigan increase photic depth increased significantly lake michigan similar equal lake huron similar equal comparing annual pre post dreissenid mussel seasonal level significant decreases lakes michigan huron mainly noted spring fall winter mixing periods recent changes water clarity lake wide photic depths lakes michigan huron superseded lake superior thus making lake superior longer clearest great lake several factors filtering activities quagga mussels phosphorus abatement climate change etc likely responsible large changes international association great lakes research published elsevier rights reserved
adaptive learning game studies experienced rapid growth due learning benefits popularity among younger generations computer programming considered challenging subject learners teachers result poor motivation towards studies important know adaptive educational games help enhance student motivation learning perceptions towards programming skills paper discusses concept using educational games learning medium applying following techniques motivation intervention collaboration etc agent based approach reinforce improve students abilities concepts programming present platform whereby instructional content methods customized individual students guide facilitate learning mastering programming concepts
alzheimer disease complex progressive neurodegenerative brain disorder prevalence expected rise next decades unconventional strategies elucidating genetic mechanisms necessary due polygenic nature work input information sources five public dna microarray measures expression levels control patient samples repositories known genes associated alzheimer disease additional data gene ontology finally literature review expert knowledge validate results methodology identify genes highly related disease present integration three machine learning techniques particularly used decision trees quantitative association rules hierarchical cluster analyze alzheimer disease gene expression profiles identify genes highly linked neurodegenerative disease changes expression levels control patient samples propose ensemble decision trees quantitative association rules find suitable configurations multi objective evolutionary algorithm garnet order overcome complex parametrization intrinsic type algorithms fulfill goat garnet executed using multiple configuration settings well known used find minimum accuracy satisfied garnet rerun identify dependencies genes expression levels able distinguish healthy individuals alzheimer patients using configurations overcome minimum threshold accuracy defined algorithm finally hierarchical cluster analysis used validate obtained gene alzheimer disease associations provided garnet results shown obtained rules able successfully characterize underlying information grouping relevant genes alzheimer disease genes reported approach provided two well defined groups perfectly divided samples healthy alzheimer disease patients prove relevance obtained results statistical test gene expression fold change used furthermore relevance summarized volcano plot showing two clearly separated significant groups genes regulated alzheimer disease patients biological knowledge integration phase performed based information fusion systematic literature review enrichment gene ontology terms described genes found hippocampus patients finally validation phase additional data permutation test carried results consistent previous studies elsevier rights reserved
relatively little known patterns school based supportive services youth autism spectrum disorder study describes supportive services correlates cross sectionally retrospectively large sample year old youth assess whether special education designation classroom placement patterns peculiar autism spectrum disorder also conducted analyses comparing youth autism spectrum disorder psychiatric diagnoses higher grades relative quantity three common supportive services received youth autism spectrum disorder decreased total supportive service quantity remained stable time youth autism spectrum disorder likely receive special education designation placed less inclusive classroom settings youth psychiatric diagnoses findings suggest youth autism spectrum disorder reach higher grades changes service provision occur terms time quantity
objectives social anxiety disorder sad common heritable psychiatric disorder however genetic studies sad rare candidate genes implicated far present study investigated whether single nucleotide polymorphisms snps associated psychiatric disorders also contribute toward development sad followed variants associated sad phenotypic level patients methods genotyped total snps german sample sad patients controls carried single marker analyses well quantitative association analyses sad severity harm avoidance results none variants investigated showed association sad case control sample bonferroni correction two snps reached nominal significance showed association allelic direction reported previously snp located within serotonin transporter gene slca primary target selective serotonin reuptake inhibitors used treatment depressive anxiety disorders quantitative association analysis cases available data symptom severity showed four snps nominal significant association among snps showed strongest association located near ank gene addition nominally associated harm avoidance scores conclusion results provide evidence involvement serotonin transporter gene slca etiology anxiety related traits furthermore study implicates genetic variation genome wide associated bipolar disorder locus ank might influence anxiety related personality traits copyright wolters kluwer health inc rights reserved
apart able support bulk student activity suitable disciplines computer programming web based educational systems potential yield valuable insights student behavior use educational analytics dispense preconceptions students consume reuse course material paper examine speed students employ concepts taught semester show wider utility data present basic classification system early detection poor performers show improved including data students use concept first time using improved classifier achieve accuracy predicting poor performers prior completion course
polyphenols ubiquitous secondary products present many plant foods intake associated health benefits ranging reduced incidence cvd diabetes cancers improved neurodegenerative outcomes major dietary sources include beverages coffee teas foods chocolate fruits also major sources berries particular palatable source diverse range polyphenol components number ways polyphenol uptake could increased healthier polyphenol rich foods could produced specific compositions target specific health effects firstly could exploit genetic diversity plants focus berries select varieties enhanced levels specific polyphenols implicated disease mitigation anthocyanins tannins flavonols working variation induced environmental agronomic factors modern molecular breeding techniques could exploit natural variation beneficially alter polyphenol content composition although could relatively long term alternatively could employ synthetic biology approach design new plants overexpress certain genes deploy metabolic effort specific polyphenols however polyphenol plus fruit could prove unpalatable polyphenols contribute sensorial properties astringency tannins however aim produce polyphenol pharmaceutical lifting biosynthetic pathways plants expressing microbial vectors may feasible option secondly could design processing methods enhance polyphenolic composition content foods fermentation teas cocoa beans grapes roasting cocoa coffee beans long used massively influence polyphenol composition potential bioactivity simple methods milling heat treatment pasteurisation juicing pureeing notable effects polyphenol profiles novel extraction methods bring new opportunities encapsulation methods protect specific polyphenols digestion increase delivery gastrointestinal tract target specific health effects lastly could examine reformulation products alter polyphenol content composition enhancing staple apple citrus juices berry juices could double polyphenol levels provide specific polyphenol components reformulation foods polyphenol rich factions recovered wastes could increase polyphenol intake alter product acceptability improve shelf life prevent food spoilage finally formulation foods influence bioavailability potential bioactivity certain polyphenols within constraints certain polyphenols interfere drug effectiveness altered metabolism provides another avenue enhance polyphenol intake potential effectiveness conclusion approaches could developed separately combination produce foods enhanced levels phenolic components effective specific disease conditions
dynamic loads high capacity power grids normal severe conditions concerns system operators dispatchers maintain voltage stability reactive power often drawn loads various generated sources disturbing operational power factor compensating methods used depending load types reactive power patterns continuously monitor correctly counteract fast changes extremely rapid var compensation especially transient conditions using power electronics combining power control engineering facts devises equipped selected power electronic switching appropriate methods respond system variations almost time statcom regulates system voltages based voltage source converters absorbing generating reactive power contrary thyristor based static var compensator svc statcom output current inductive capacitive controlled independent system voltage paper presents design voltage controller analyze validate dynamic behavior facts device statcom riding severe transient imbalance using powerful computer simulation application pscad emtdc statcom modeled phase network various parameters steady state condition short interval system fault regulator provided ride severe transient maintaining sufficient bandwidth perform necessary compensations controller behavior simulated distribution system model subjected severe three phases ground fault rapidly varying three phase load
several studies investigating causes delay projects construction industry conducted worldwide study investigates causes delay construction projects oil gas processing facilities oman serves case study gulf cooperation council gcc countries using questionnaire data collected project managers employed different organizations oil gas industry oman survey results showed high degree agreement among perceptions project stakeholders clients contractors consultants causes project delay evidence suggest causes project delay differ significantly according organization size organizational ownership moreover seven factors identified major causes project delay although six identified elements general factors account delay project industry one thempoor interaction vendors engineering procurement stagesis found unique construction projects oil gas industry findings study could value organizations planning conduct construction projects oil gas processing facilities oman nations similar environments gcc countries
studies shown evening type subjects used stimulating sedative substances presented psychiatric disorders morning type subject however lack data chronotype patients addiction aim study describe chronotype associated factors sample outpatients beginning treatment addiction subjects assessed morningness eveningness questionnaire horne ostberg addiction severity index mini international neuropsychiatric interview subjects addiction comparing multivariate analysis showed significantly associated poly problematic addiction non substance addictions cannabis addiction mood disorders severity addiction associated antisocial personality disorder results suggested chronotype associated specific addiction pattern psychiatric disorders elsevier ireland ltd rights reserved
fuzzy time jit ubiquitous service networked system established study system innovative application mobile commerce ubiquitous computing ambient intelligence intended user traveler must decide best service location along planned route system arranges service user demands user arrives service location required service ready system applies time concept mobile commerce ubiquitous computing ambient intelligence innovation great potential providing better services fields issue determine jit service location path ubiquitous service network critical however data user position inaccurate task difficult tackle difficulty finlp model formulated fuzzy version dijkstra algorithm proposed test system established evaluate feasibility proposed methodology based experimental results proposed jit ubiquitous service networked system able reduce user average waiting time
objectives describe prevalence risk drinking participation health related behaviors practices associations risk drinking health related behaviors practices among older persons completing health risk appraisal elderly hra design cross sectional study using data self administered mailed survey sample settings persons three organizations surveyed american association retired persons large medical group community based senior health center southern california participants persons age years older measurements hra included items health characteristics drinking behaviors including amount alcohol use two alcoholism screening measures cage cut annoyed guilty eye opener short michigan alcoholism screening test geriatric version smast participation selected health related behaviors practices social drinkers defined drank fewer drinks weekly screened negative cage defined two responses smast hazardous drinkers drank fewer drinks weekly screened negative harmful drinkers drank fewer drinks weekly screened positive possible risk drinkers drank drinks weekly screened positive least squares regression models used assess effects haz ardous harmful possible risk drinking health related practices behaviors also conducted analyses using three definitions social possible risk hazardous harmful drinking results respondents social drinkers harmful drinkers hazardous drinkers possible risk drinkers hazardous harmful possible risk drinkers commonly reported driving drinking driven someone drinking respectively harmful possible risk drinkers likely social drinkers smoke less likely use seatbelts regularly findings observed regardless drinking groups defined conclusion groups risk drinkers commonly engaged selected adverse health related behaviors practices social drinkers
nowadays garment industries developing traditional manufacture industry culture creative industry china knowledge employees garment industry facing new challenges work stress high requirements organizational management needed current circumstance article indicated work stress knowledge employees garment industry reached middle level researched discovered different characteristics work stress basis demographic variables empirical research order adhere philosophy people oriented organization strengthen work stress management high value importance improving human resource management also enhancing potentiality knowledge employees expanding organization performance practically time future
magnetorheological elastomers mres kind smart material whose mechanical properties controllable applied magnetic field moreover greater magnetorheological effect mres small strain amplitude attracted attention field microvibration control paper mre isolator shear compression mixed mode developed suppress high frequency microamplitude vibration precision fabrication platform evaluate characterize dynamic behavior mre isolator experiments conducted harmonic load different magnetic fields respectively experiments showed resonance frequency mre isolation system shifted meanwhile relative change equivalent stiffness damping respectively relative change isolator force proposed mixed mode mre isolator effectively isolated vibration high frequency microamplitude
biologics disease modifying antirheumatic drugs bdmard use germany treatment rheumatoid arthritis since usually failure least one conventional synthetic dmard analyzed temporal changes factors influence decision either first bdmard csdmard analyzed data bdmard naive patients german biologics register rabbit switched new therapy three recruitment periods factors influencing therapeutic decision analyzed means machine learning methods logistic regression analysis recruitment periods number previous csdmards high dosages glucocorticoids day higher das significantly associated decision first bdmard time chance receiving bdmard increased patients moderate disease activity moderate glucocorticoid dosages day comorbidities congestive heart failure prior malignancy men higher chance receiving bdmard women first recruitment period private health insurance high education gainful employment significantly associated frequent prescription bdmards recruitment periods time dependent changes impact disease activity concomitant drugs gender comorbidity prescription bdmards mirror increasing therapeutic options growing experience application new substances patients higher risk influence demographic social factors may reflect safety concerns patients increased risk adverse events also need economize drug costs
paper aims find critical factors success ready made garment rmg industry bangladesh especially manufacturing engineering aspects basically garment product must competitive terms quality cost time evaluation index system product strategic aspects constructed paper fuzzy analytical hierarchy process fahp used give evaluation product strategic aspects ready made garment enterprise bangladesh managers adopt effective product strategies
hematopoietic cell transplantation hct rapidly evolving field active preclinical clinical development new strategies patient assessment graft selection manipulation pre post transplantation drug cell therapy new strategies require evaluation definitive clinical trials however hct trials face unique challenges including relatively small number transplantations performed single center diverse indications hct requiring dissimilar approaches complex nature intervention risk multiple complications immediate post transplantation period risk important though infrequent late effects blood marrow transplant clinical trials network bmt ctn established national heart lung blood institute national cancer institute meet challenges years network bmt ctn proven successful infrastructure planning implementing completing trials providing definitive answers questions leading improvements understanding practice hct opened trials one half phase one half phase enrolled patients published papers addressing important issues treatment patients life threatening malignant nonmalignant blood disorders review describes network accomplishments key components success lessons learned past years challenges future american society blood marrow transplantation published elsevier inc
recent biological study shows extremely good efficiency fruit flies finding food despite small brain emerges two distinct stimuli smell visual contrast contrast based fruit fly optimization presented paper first time mimicking fruit fly behaviour developing means efficiently address multi parameter optimization problems assess performance study carried ten mathematical three truss optimization problems results compared obtained using twelve state art optimization algorithms confirm good robust performance sensitivity analysis evaluation performance parallel computing conducted proposed algorithm tuning parameters intuitive multi faceted allowing application complex dimensional design optimization problems elsevier ltd rights reserved
psoriasis chronic inflammatory skin disorder aim study determine potential role microrna mir psoriasis underlying mechanism expression levels mir psoriasis specimens normal skin tissues analyzed mir mimic inhibitor mir control small interfering rna sirna specific serine threonine kinase stk sex determining region chromosome box sox transfected human keratinocyte hacat cells respectively transfection cell viability apoptosis migration determined luciferase reporter assay quantitative reverse transcription polymerase chain reaction western blot performed explore whether stk target mir effects aberrant expressions mir stk sox key proteins jun terminal kinase jnk mitogen activated protein kinase mapk pathway assessed mir levels significantly higher patients psoriasis compared healthy controls overexpressing mir strikingly promoted hacat cell viability migration inhibited apoptosis confirmed stk direct target mir stk involved mir induced cell functions overexpressing mir significantly upregulated sox jun jnk pmapk proteins silencing mir downregulated addition silencing stk alleviated effects anti mir sox expression furthermore silencing sox also decreased levels jun jnk pmapk proteins mir regulates human keratinocyte hacat viability migration apoptosis might direct regulation stk mediated pathway indirect regulation sox mediated downstream jnk mapk signaling pathway
radiofrequency parathyroid ablation noninvasive treatment hyperparathyroidism dogs published data assessing factors associated parathyroid ablation success failure order guide patient selection improve outcome purpose retrospective analytical study determine whether imaging findings biochemical data concurrent diseases associated heat ablation treatment failure inclusion study dogs must clinical diagnosis primary hyperparathyroidism undergone cervical ultrasound ablation abnormal parathyroid tissue must least months follow information available following date ultrasound guided parathyroid ablation dogs grouped based recurrent persistent hypercalcemia without recurrent persistent hypercalcemia following therapy parathyroid nodule size thyroid lobe size nodule location presence concurrent disease recorded recurrence hypercalcemia occurred dogs ablation abnormal parathyroid tissue one patient persistent hypercalcemia following parathyroid ablation nodule width height largest cross sectional area larger dogs recurrent persistent hypercalcemia following ablation hypothyroidism common dogs recurrent disease radiofrequency ablation successful dogs larger parathyroid nodule size concurrent hypothyroidism associated treatment failure dogs underwent ultrasound guided parathyroid nodule ablation american college veterinary radiology
background study assesses accuracy comprehensiveness online public health education materials three australian cities active lead mines smelters broken hill mount isa port pirie methods qualitative content analysis online australian material comparison international best practice possible results materials provided incomplete information health effects lead pathways exposure compared best practice materials inconsistent strategies reduce exposure lead identified among australian cities evidence based best practices included materials normalised environmental lead neglected identify safe level lead primary prevention best strategy protecting children health conclusions health education materials need clearly state health risks lead across developmental stages sensitive populations integrate primary prevention perspective provide comprehensive evidence based recommendations reducing lead exposure around home families rely information provided online public education materials likely inadequately informed importance protecting children exposure lead strategies
background previous research demonstrated influence food safety climate food safety output food companies organizational company level individual level relation food safety climate employees food safety behavior still unraveled therefore conceptual food safety culture model boeck jacxsens bollaerts vlerick expanded introducing food safety behavior composed food safety compliance participation represent obligated food safety related activities achievement additional voluntary food safety related activities knowledge motivation burnout jobstress individual employees organization scope approach present study relationship food safety climate food safety behavior investigated food safety knowledge motivation proposed mediators explaining relationship climate behavior additionally jobstress burnout proposed moderators influencing strength relationship conceptual model tested statistical analysis data collected two belgian vegetable processing companies self assessment surveys key findings conclusions positive relationship food safety climate employees behavior found mediation analysis showed knowledge partial mediator food safety climate compliance participation behavior means knowledge fully explain relationship motivation partial mediator food safety climate compliance behavior moderation effect jobstress burnout confirmed results demonstrate direct without mediation indirect effect motivation knowledge food safety climate employees behavior illustrate key role employees behavior well governing food safety company study suggests human factors might impact implementation follow food safety management system recommends human behavioral approach food safety management food companies elsevier ltd rights reserved
objectives estimate life expectancy years hiv positive people compare life expectancy recent estimates general population education methods patients aged years older enrolled swiss hiv cohort study eligible patients alive matched swiss residents sex year birth education life expectancy age estimated monotherapy dual therapy early combination antiretro viral therapy cart later cart recent cart eras parametric survival regression used model life expectancy results hiv positive patients residents included life expectancy age hiv positive individuals increased years confidence interval monotherapy era years recent cart era differences life expectancy across educational levels emerged cart recent cart period life expectancy age years years compulsory education compared years higher education estimates general population years respectively male sex smoking injection drug use low cell counts enrolment also independently associated mortality conclusion switzerland educational inequalities life expectancy larger among hiv infected persons general population highly educated hiv positive people estimated life expectancy similar swiss residents compulsory education earlier start cart effective smoking cessation programs could improve hiv positive life expectancy reduce inequalities copyright wolters kluwer health inc rights reserved
although idea pulse music may related human pulse ancient recently promoted researchers parncutt snowdon teie ordered delineation characteristics music based sounds womb describe features music based sounds present womb tempo pulse pulse understood regular underlying beat defines meter amplitude contour pulse meter musical notes melodic frequency range continuity syllabic contour melodic rhythm melodic accents phrase length phrase contour number features prenatal development allow formation long term memories sounds womb areas brain responsible emotions taken together features similarities sounds womb elemental building blocks music allow postulation fetal acoustic environment may provide bases fundamental musical elements found music cultures hypothesis supported one one matching universal features music sounds womb regularly heard sounds present fetal environment represented music every culture features music present music cultures traced fetal environment
work demonstrate innovative cleanroom customized dvd fabrication process successfully used mass production biosensors thin film electrodes show silver gold electrodes used impedimetric voltammetric biosensing applications presence absence redox mediator modeled redox non redox electrodes impedance equivalent electrical circuits evaluated transfer function sensitivity one factor time approach using approach introduced new prediction method find equivalent electrical circuit elements contribute transfer function variations experimentally validated predictions measuring electrodes electrochemical impedance spectroscopy responses relevant self assembled monolayer molecules immobilized mch dtsp also assess silver electrodes long term stability impedance spectroscopy measurements period hours proving possible use point care applications finally also prove sensors correctly perform practical case lactic acid biosensor studying optimization biosensor efficiency different enzyme immobilization methods comparing lactate oxidase enzyme direct adsorption covalent binding dtsp self assembling monolayers found covalent binding dtsp boost catalytic current respect obtained direct adsorption enzyme concentration
backgroundspinal cord stimulation scs valuable resource treatment chronic nonmalignant pain persists face maximal medical management recent study demonstrated efficacy cervical scs multicenter registry single center study able delve patient specifics explore outcomes percutaneous paddle implants examine impact patient symptomatology methodswe prospectively collected data subjects underwent cervical scs via numeric rating scale nrs mcgill pain questionnaire oswestry disability index odi beck depression inventory subjects completed battery pre operatively six months one year data analyzed via repeated measures anova bivariate correlation analysis paired tests resultsin consecutive subjects complete data set diagnosis failed neck surgery syndrome complex regional pain syndrome neuropathic pain compared baseline nrs score significantly improved six months one year odi score also improved one year six months one year subjects percutaneous implants reported significantly less disability odi respectively compared received paddle implants difference nrs score outcome measure based type implant diagnosis region pain correlate measure outcome discussionwe demonstrate neck arm pain improved cervical scs six month one year follow ups percutaneous paddle implants benefit tend place percutaneous implants radicular pain retrograde paddles axial pain ineffectively treated trial
background kratom mitragyna speciosa tropical tree long history traditional use parts africa southeast asia kratom also known thom thang biak leaves teas brewed long used people region manage pain opioid withdrawal stave fatigue kratom actually consumed throughout world stimulant effects opioid substitute form tea chewed smoked ingested capsules case reports associated kratom exposure psychosis seizures intrahepatic cholestasis medical conditions deaths clinical manifestations kratom effects well defined clinical studies limited data research suggest stimulant sedative dose dependent effects exist addition antinociceptive antidepressant activity anxiolytic like effects anorectic effects growing concern drug effects safety use resulted national international attention primarily due increase hospital visits deaths several countries believed caused extracts plant dearth double blind controlled studies study aim use existing literature clarify benefits risks kratom well diagnosis evaluation kratom misuse emerging trend western world methods literature review using databases embase medline pubmed cochrane library mendeley evaluated authors analyze current state benefits risks diagnosis evaluation kratom speciosa results data analysis suggested kratom possesses benefits stimulant sedative effects wells antinociceptive effects seems inhibit pro inflammatory mediator release vascular permeability enhance immunity addition may antidepressant anorectic however kratom cause intrahepatic cholestasis seizure arrhythmia impair memory function coma death psychological manifestations described euphoria feeling relaxed severe symptoms aggression hostility psychosis medical manifestations described polyuria dry mouth vomiting jerky movements currently liquid chromatography mass spectrometry ion mobility spectrometry ims suggested promising rapidly screen kratom products providing positive success rate conclusion data analysis determined biochemical benefits kratom may prove outweigh toxicity risks contrary seems potential side effects outweigh benefits severe real health hazards insidiously lead death kratom clinical psychological medical manifestations disturbing kratom speciosa use among multiple compounds leaf appear increasing western world promising methods accurately identify kratom compounds still ongoing
paper presents three dimensional space vector pulse width modulation svpwm technique via orthonormal transformation matrix used new approach controlling three phase four leg voltage source inverter vsi fully optimal digital control scheme closed loop regulation three phase four leg vsi used synthesize sinusoidal waveform help proposed method discrete time modelling phase obtained independently abc reference frame optimal controller designed using predefined performance index dsp based controlled three phase four leg prototype vsi designed verify proposed discrete time modelling control scheme simulations real time experiments show satisfactory results obtained modelling three phase four leg vsi abc reference frame svpwm technique via orthonormal transformation matrix khz switching frequency
descriptive epidemiological information myeloproliferative neoplasms mpns myelodysplastic mds mpns largely derived single institution european population based studies data obtained following adoption world health organization classification haematopoietic neoplasms jak mutation testing sparse using population based data comprehensively assessed subtype specific mpn mds mpn incidence rates irs ratios irrs relative survival united states irs highest polycythaemia vera essential thrombocythaemia except mastocytosis overall irs significantly higher among males irrs evaluable mpns associated lower irs among hispanic whites non hispanic whites nhws exception bcr abl positive chronic myeloid leukaemia cml chronic eosinophilic leukaemia cel juvenile myelomonocytic leukaemia except cel asians pacific islanders significantly lower mpn irs nhws mpn unclassifiable cel irs higher respectively among blacks nhws five year favourable younger younger patients lowest older chronic myelomonocytic leukaemia atypical bcr abl negative cml patients varying mpn mds mpn incidence patterns subtype support distinct aetiologies susceptible populations decreased survival rates compared expected general population associated every mpn subtype highlighting need new treatments particularly among older individuals
rising level electromagnetic pollution recorded recent years represents serious threat reliability electronic devices systems life plenty besides corrupting nominal signals electromagnetic interference emi collected interconnects drive active nonlinear devices integrated circuits made nominal operating region usually results distortion signals harmful effect process generation baseband intermodulation products demodulated emi distinguished nominal signals unlikely point addressed first part paper expression offset induced radio frequency interference mos differential pair derived used show effect emi feedback operational amplifiers techniques obtain higher immunity levels also presented second part paper focuses low offset low noise amplifiers common use sensor signal conditioning circuits usually show high susceptibility emi aiming address issue new technique based dynamic cancelation emi induced errors presented evidences effectiveness provided showing simulation measurement results
herv family human endogenous retroviruses represents group numerous sequences show close similarity genetic composition documented members herv derived expression products supposed play significant role humans pathology multiple sclerosis schizophrenia members family necessary orchestrate physiological processes ervwe coding syncytin engaged syncytiotrophoblast formation therefore assay would allow recognition particular form herv members highly desirable peptide nucleic acid pna mediated technique discrimination multiple sclerosis associated retrovirus ervwe sequence developed assay uses pna probe fully complementary ervwe multiple sclerosis associated retrovirus msrv template shows high selective potential single stranded dna binding protein facilitates pna mediated sequence specific formation strand invasion complex consequently local dna unwinding target dna may excluded analysis downstream process single stranded dna specific exonuclease action finally reaction conditions optimized several pna probes targeted toward distinct loci along whole herv env sequences evaluated believe pna single stranded dna binding protein based application potential selectively discriminate particular herv molecules least suspected play pathogenic role broad range medical conditions psycho neurologic disorders multiple sclerosis schizophrenia cancers breast cancer auto immunologic background psoriasis lupus erythematosus
sensors based ceramic semiconducting substrates flexibility biocompatibility polymer based sensors subject much attention due ability collect molecules sensing surface flexibility beyond polymer based sensors recent discovery cellulose smart material paved way use cellulose paper potential candidate mechanical well electronic applications actuators sensors several different paper based sensors investigated suggested paper review potential cellulose materials paper based application devices suggest feasibility chemical biosensor applications
soybean glycine max merr recognized potent food allergen causing one frequent food allergies worldwide effect high pressure processing hpp prior enzymatic hydrolysis using enzyme preparation flavourzyme degree hydrolysis molecular weight distribution sdspage beta conglycinin gly immunoreactivity soy protein isolate spi studied enzymatic hydrolysis carried atmospheric pressure mpa hpp mpa degrees min pressures higher mpa enhanced degradation gly confirmed sds page analyses immunoreactivity samples assessed vitro sandwich elisa using mouse monoclonal anti gly antibodies depending antibody tested residual immunoreactivity completely inhibited significantly impaired applying hpp hydrolysis mpa means principal component analysis beany green flavors characteristic unprocessed spi could reduced pressure enhanced hydrolysis mpa resulting hydrolysates possessed improved protein solubility foaming activities oil binding capacities improved respectively hpp prior enzymatic hydrolysis mpa constitutes innovative approach production low allergen food ingredients combine good taste enhanced functional properties industrial relevance food allergy emerged last years incidence prevalence rising dramatically enzymatic hydrolysis feasible method mitigate soy allergy however major drawback associated enzymatic hydrolysis incomplete destruction allergenic epitopes formation strong bitter taste research activity demonstrates high pressure assisted enzymatic hydrolysis using enzyme preparation flavourzyme effectively reduces immunoreactivity soy proteins degree hydrolysis analysis sds page mass spectrometry well sandwich elisa mouse monoclonal anti gly antibodies applied analyze destruction allergenic proteins well determine residual immunoreactivity study provides preliminary evidence innovative combination process high pressure enzymatic hydrolysis great potential produce tasty low allergen soy based food ingredients good physicochemical properties protein solubility foamability elsevier ltd rights reserved
paper presents new hybrid structure machine possesses distinct merit multimode fault tolerant operation driving mars rover namely proposed machine designed three operation modes including mode normal operation mode remedial field excited operation mode iii remedial rotor operation obtain operation modes machine design adopts outer rotor structure segmented iron ring special teeth split inner stator way proposed machine capable providing desired torque output low speeds normal fault situations machine design principle corresponding results given verify validity idea furthermore different combinations torque outputs different operation modes four wheel motors mars rover analyzed discussed
prediction bankruptcy financial companies especially banks extensively researched area creditors auditors stockholders senior managers interested bank bankruptcy prediction paper three common machine learning models namely logistic voted perceptron used base learners addition attribute base ensemble learning method namely random subspaces two instance base ensemble learning methods namely bagging multi boosting employed enhance prediction accuracy conventional machine learning models bank failure prediction models grouped following families approaches conventional machine learning models ensemble learning models iii hybrid ensemble learning models experimental results indicate clear outperformance hybrid ensemble machine learning models conventional base ensemble models results indicate hybrid ensemble learning models used reliable predicting model bank failures
network time protocol based ddos attacks saw lot popularity throughout paper shows characterization analysis two large datasets containing packets ntp based ddos attacks captured south africa using series python based tools dataset analysed according specific parts packet headers include source address time live ttl values analysis found top source addresses looked ttl values observed address ttl values used calculate probable operating system ddos attack tool used attacker found ttl value seen address indicate number hosts attacking address indicate minor routing changes time live values analysed whole find total number used throughout attack frequent ttl values found show majority indicate attackers using initial ttl value indicate use certain ddos tool creates packets exact initial ttl ttl values put groups show number addresses group hosts targeting paper discusses work two brief case studies correlating observed data real world attacks observable impact thereof
tla contributes pathogenesis several chronic inflammatory diseases including bowel enhancing responses tla mediates strong costimulation subsets particularly mucosal ccr cells however signaling pathways tla induces different subsets incompletely understood investigated function tla human cells tla together tgf enhanced secretion ifn human memory cells tla induced expression transcription factors batf bet correlated secretion ifn contrast tla alone induced high levels memory cells committed cells however tla enhance expression cells expression transcription factor aryl hydrocarbon receptor regulates expression affected tla transcriptome analysis cells revealed increased expression response tla blocking receptor antibodies abrogated tla induced secretion furthermore tla increased production peripheral cells isolated patients crohn disease data suggest tla differentially induces expression effector cytokines provides potential target therapeutic intervention driven chronic inflammatory diseases
rationale idiopathic pulmonary fibrosis ipf progressive fatal interstitial lung disease ild characterized abnormal extracellular matrix ecm remodeling hypothesized ecm remodeling might result plasma profile proteins specific ipf could distinguish patients ipf idiopathic ilds objectives identify biomarkers might assist distinguishing ipf non ipf ild methods developed panel ecm ecm related lung specific analytes measured plasma patients ipf derivation cohort patients ipf validation cohort comparison groups included patients rheumatoid arthritis associated ild ild patients alternative idiopathic ilds ild healthy control subjects univariable multivariable logistic regression models identified biomarkers differentiated patients ipf ild continuous diagnostic threshold versions biomarkers considered thresholds chosen maximize summed diagnostic sensitivity specificity univariate receiver operating characteristic curve analysis diagnostic score created promising analytes measurements main results plasma surfactant protein matrix metalloproteinase mmp osteopontin significantly distinguished patients ipf patients ild individually combined index odds ratio ipf least one analyte index exceeded threshold confidence interval least two analytes elevated odds ratio ipf increased confidence interval conclusions biomarker index mmp osteopontin enhanced diagnostic accuracy patients ipf compared non ipf ild data suggest biomarker index may improve diagnostic confidence ipf
objective mexico specialized treatment services people occurring disorders limited within public health services private options deemed costly community based residential care facilities risen alternative main source treatment individuals substance use disorders however suboptimal practices within facilities common information clinical characteristics patients receiving care facilities scarce capacity provide high quality care occurring disorders unknown aims study examine prevalence occurring disorders patients receiving treatment substance use community based residential centers assess whether presence occurring disorders associated higher severity substance use psychiatric symptomatology health risks methods study conducted patients receiving treatment substance use disorders facilities located five mexican states recruited patients assessed self report measures substance use service utilization suicidality hiv risk behaviors psychiatric symptomatology psychiatric disorder diagnostic criteria results prevalence occurring disorder sample antisocial personality disorder prevalent followed major depressive disorder presence occurring disorder associated higher severity psychiatric symptoms days substance use current suicidal ideation aor plans aor attempts aor sexual risk behaviors contact professional services aor conclusions occurring disorders highly prevalent community based residential centers mexico associated significantly increased probability health risks highlights need develop care standards population importance clinical research settings
integration cloud mobile device enables users convenient access retrieve file due limitations resources mobile devices shorten search time get accurate target files avoid unnecessary consumption become focus research paper presents efficient searchable encryption scheme based mobile cloud scheme combine nearest neighbor algorithm design initial trap door matching table tmt realizes multi keyword boolean search improve query precision shorten searching time
heat exchanger plays vital role chemical plants withstand wide range pressure temperature heat exchanger transmit heat hot liquid cold liquid order avoid loss heat chemical processes proposed different tuning strategies pid controller control cold water temperature desired set point best controller tuning method found transient response performance error criteria simulation performed using matlab different tuning strategies pid controller model result ensure particle swarm optimization based pid provides efficient control action conventional pid internal model control based pid controller
study experiments aimed analyzing thermally exhaust valve air cooled internal combustion engine estimating thermal contact conductance fixed periodic contacts due nature internal combustion engines duration contact valve seat short much time needed reach quasi steady state periodic contact exhaust valve seat using methods linear extrapolation inverse solution surface contact temperatures fixed periodic thermal contact conductance calculated results linear extrapolation inverse methods similar trends based error analysis accurate enough estimate thermal contact conductance moreover due error analysis linear extrapolation method using inverse ratio preferred effects pressure contact frequency heat flux cooling air speed thermal contact conductance investigated results show increasing contact pressure thermal contact conductance increases substantially addition increasing engine speed thermal contact conductance decreases hand boosting air speed thermal contact conductance increases raising heat flux thermal contact conductance reduces average calculated error equals
release first version iso standard automotive systems demand elicitation safety goals following rigorous method hazard risk analysis companies struggling adoption standard due ambiguities documentation demands alignment standards demands existing processes previously proposed structured engineering method deal problems developed applying action research together oem work evaluate applicable method junior automotive software engineers descriptive study provided method members master course automotive software engineering ase technical university munich participants working automotive industry years parallel studies investigated application method electronic steering column lock system participants applied method first round alone afterwards discussed results groups data analysis revealed participants could apply method successfully hazard analysis risk assessment achieved high precision productivity moreover precision could improved significantly group discussions
nanotechnology application concrete presents innovative approach improve concrete properties based ability manipulate cementitious material atomic scale paper presents review nano materials used concrete literature survey revealed four nano materials often used modify concrete properties include nano silica nano sio nano titanium dioxide nano tio carbon nano tubes cnts carbon nano fibres cnfs four nano materials shown improvement many concrete properties nano tio nano sio reduce bleeding segregation improve mechanical transport properties cnfs cnts tend adversely affect fresh properties due agglomerations overcome surfactant ultrasonic mixer used however cnfs cnts significantly improve mechanical properties concrete paper also discusses concrete durability improved nano materials added concrete addition paper identifies several research needs based gaps current state knowledge using nano materials concrete
rotary drilling rig kind construction machinery used deep pile foundation hole drilling operation recent years significant amount catastrophic plastic hinge type bending failures occurred masks drilling machines major cause leading disaster due sudden breaking drilling pipe lifting wire rope drilling rig experience severe transient dynamic process immediately accidental breaking lifting wire rope current design routine drilling rigs normally based static analyses dynamic processes seldom considered due complexity involved analyses paper parametric finite element model entire machine rotary drilling rig established transient dynamic analyses carried response load case wire rope drilling pipe lifting breaks history stress variation whole machine dynamic response process obtained could used check machine designed safe case drilling pipe lifting wire rope breaks
background internet surveys draw traditionally generated samples provide unique conditions engage adolescents exploration sensitive health topics methods examined awareness unwanted pregnancy abortion behaviour methods attitudes toward specific legal indications abortion via school based internet survey among adolescents aged years three rio janeiro public schools results forty five percent knew peers undergone abortion students disclose abortion method knowledge however girls aor experienced sexual debut aor attending prestigious magnet school aor likely report methods abortion methods reported ineffective obsolete unsafe herbs marijuana tea counter medications surgical procedures foreign objects blunt trauma reported techniques perceived dangerous including methods recommended world health organization majority supported brazil existing law permitting abortion case rape association gender age sexual debut parental education socioeconomic status attitudes toward legal abortion however students magnet school supported twice many legal indications suggesting likely role peers educators shaping abortion views conclusions abortion knowledge attitudes driven simply age religion class rather complex interplay includes social spaces gender prevention abortion morbidity mortality among adolescents requires comprehensive sexuality reproductive health education includes factual distinctions safe unsafe abortion methods
increasing demand machine machine communications internet things iot services necessary develop new network architecture protocols support cost effective distributed computing systems generally iot applications serve large number intelligent devices sensors actuators distributed large geographical areas deploy communication iot sensor nodes cost effective manner large geographical area necessary develop new network architecture cost effective well energy efficient paper presents ieee ieee standards based heterogeneous network architecture support communication services wide geographical area proposed heterogeneous network developed new cooperative carrier sense multiple access collision avoidance csma medium access control mac protocol transmit packets using shared channel ghz ism band one key problems ieee heterogeneous network dense networking environment coexistence problem two protocols interfere causing performance degradation paper introduces cooperative mac protocol utilizes new signaling technique known blank burst avoid coexistence problem proposed mac protocol improves network qos area networks developed network architecture offers significant energy efficiency operational expenditure opex capital expenditure capex advantages cellular standards based wide area networks
computational fluid dynamics cfd rapidly emerging field wastewater treatment wwt application almost unit processes paper provides overview cfd applied wide range unit processes water wwt hydraulic elements like flow splitting physical chemical biological processes like suspended growth nutrient removal anaerobic digestion paper focus articulating state practice research development needs level cfd capability varies different process units high frequency application areas final sedimentation activated sludge basin modelling disinfection greater needs primary sedimentation anaerobic digestion approaches comprehensive generally capable incorporating non newtonian fluids multiphase systems biokinetics broad work done address diversity process designs many units addressed date needs identified throughout common requirements include improved particle aggregation breakup flocculation improved coupling biology hydraulics
increasing integration fluctuating non linear loads main grid introduce problems distribution power system quality study interested micro grid based rdg renewable distributed generator participate system services improve efficiency power electrical system purpose paper investigate multi objective control strategy integration electrical network order ensure simultaneously active power supply reactive power compensation harmonic current damping grid frequency regulation control mainly composed two parts first one loads currents identification system used extract fundamental active current disruptive one order provide required harmonic reactive currents considered loads second one active power transfer frequency control algorithm used manage six operation modes order control fundamental active power flow exchange electrical network making grid frequency allowable range stability elsevier ltd rights reserved
parkinson disease circuit level disorder clinically determined motor subtypes despite evidence suggesting subtype may different pathophysiology neuroimaging studies examined levodopa induced differences neural activation tremor dominant postural instability gait difficulty pigd subtype patients motor task goal functional mri fmri study examine task induced activation connectivity cortico striatal thalamo cortical motor circuit healthy controls patients pigd patients levodopa administration fourteen pigd cognitively intact patients age sex matched healthy controls completed right hand paced tapping fmri paradigm collectively patients medication showed hypoactivation motor cortex relative healthy controls even controlling performance levodopa intake pigd patients significantly increased activation left putamen compared patients healthy controls psychophysiological interaction analysis revealed levodopa increased effective connectivity posterior putamen areas motor circuit tapping patients pigd patients novel levodopa induced difference neural responses motor subtypes may significant implications elucidating mechanisms underlying distinct phenotypic manifestations enabling classification motor subtypes objectively using fmri
objectives prehypertension may precursor hypertension important public health problem community myocardial performance index mpi noninvasive doppler measurement global ventricular function thus aim evaluate left ventricule functions mpi prehypertensive patients normal coronary artery angiography patients materials forty prehypertensive patients women men blood pressures mmhg normotensive controls women men blood pressures mmhg included study patient population comprised underwent coronary angiography typical angina normal coronary arteries mpi calculated compared two groups results statistically significant differences found two groups terms age sex demographic characteristics moreover ejection fraction late diastolic flow deceleration time isovolumetric contraction time ejection time values significantly different two groups however early diastolic mitral inflow velocity ratio isovolumetric relaxation mpi significantly higher patient group control group conclusion mpi increased prehypertensive patients result demonstrates diastolic systolic functions may negatively affected patients prehypertension advantages method follows simple demand special equipment time consuming copyright wolters kluwer health inc rights reserved
amorphous tbfeco material perpendicular magnetic anisotropy currently attracting attention potential applications spintronic devices logic memories systematically investigate magnetic structural thermal optical electrical properties tbfeco alloy films shows plane easy axis films turns plane orientation annealing significant increase saturation magnetization temperature range degrees revealed thermomagnetic measurements occurrence crystallization oxidation high temperatures confirmed ray diffraction measurements pronounced changes optical reflectance sheet resistance observed temperature line structural relaxation change activation barriers crystallization oxidation determined respectively feco rich rich samples better thermal stability crystallization oxidation demonstrated feco rich sample rich type results provide useful information alloy used device fabrication elsevier rights reserved
compared people never engaged nonsuicidal self injury nssi people history nssi report multiple interpersonal problems theories propose interpersonal difficulties play role prompting maintaining nssi cross sectional nature studies area limits understanding day day interpersonal experiences relate global interpersonal impairments observed among individuals nssi vice versa study compared young adults without recent repeated nssi baseline daily measures interpersonal functioning day daily diary study groups differed baseline social anxiety excessive reassurance seeking use support seeking relative coping strategies differ self perceived interpersonal competence terms day day functioning participants without nssi significantly less contact families friends perceived less support following interactions friends less likely seek support cope regardless level negative affect exception contact family members group differences daily interpersonal functioning accounted baseline levels social anxiety use support seeking contrary expectations participants nssi frequent contact romantic partners differ perceptions support romantic relationships report intense negative affect following negative interpersonal interactions study provides novel test recent interpersonal theories nssi using daily reports
recently single nucleotide polymorphism snp abo gene related large artery atherosclerotic laa stroke caucasian populations genome wide association study gwas study aimed determine whether abo gene polymorphisms associated laa stroke chinese han population case control study designed patients laa stroke healthy controls enrolled ten tagging snps tsnps located abo gene genotyped associations genotypes laa stroke analyzed logistic regression model adjustment potential confounders although associated laa stroke genotype adjusted two novel snps genotype adjusted genotype adjusted associated laa stroke haplotype analysis indicated haplotype adjusted block haplotype aca block associated laa stroke multifactor dimensionality reduction mdr analysis single locus model indicated important attributor predicting risk laa stroke significant snp snp interactions among tested snps detected results indicated genetic variants abo gene may influence risk laa stroke chinese han population
addition equiv tfa acetone solution containing dodecaphenylporphyrin hdpp presence meoh resulted selective formation monoprotonated form hdpp sharp contrast protonation hdpp directly affording diprotonated form hdpp acetone absence meoh crucial role meoh selective hdpp formation interpreted hydrogen bonding stabilization hdpp since meoh molecule found form hydrogen bonds proton hdpp crystal selectivity hdpp formation evaluated formation yield hdpp increased elevating portion meoh acetone saturation behavior suggesting hdpp stabilized hydrogen bonding meoh even solution together thermodynamic parameters determined van hoff plot based spectroscopic titration femto nanosecond laser flash photolysis allowed elucidate photodynamics hdpp intermolecular photoinduced electron transfer ferrocene derivatives one electron donors triplet excited state hdpp electron acceptor second order rate constants reactions evaluated light marcus theory reorganization energy determined slightly larger hdpp acetonitrile due larger structural change upon hdpp
rgb data turned useful representation indoor scene solving fundamental computer vision problems takes advantages color image provides appearance information object also depth image immune variations color illumination rotation angle scale invention low cost microsoft kinect sensor initially used gaming later became popular device computer vision high quality rgb data acquired easily recent years rgb image video datasets dedicated various applications become available great importance benchmark state art paper systematically survey popular rgb datasets different applications including object recognition scene classification hand gesture recognition simultaneous localization mapping pose estimation provide insights characteristics important dataset compare popularity difficulty datasets overall main goal survey give comprehensive description available rgb datasets thus guide researchers selection suitable datasets evaluating algorithms
large scale open storage wood mulch common practice wood recycling facilities rain snow melt leachate soluble compounds suspended particles released mulch stockpiles objective study determine quality leachate runoff wood recycling facilities evaluate potential contaminate receiving waterbodies wood mulch leachate runoff samples collected years three wood recycling facilities new jersey usa differences site found constituents tested solid wood mulch samples biochemical oxygen demand range chemical oxygen demand total suspended solids median concentrations leachate runoff samples comparable untreated domestic wastewater total kjeldahl total fecal coliform median values slightly lower typical wastewater values dose response studies leachate runoff samples using zebrafish danio rerio embryos showed mortality developmental defects typically occur even highest concentration tested indicating low toxicity although delayed development occur based study leachate runoff wood recycling facilities released surface waters potential source organic contamination low levels nutrients study runoff controlled drainage area containing wood mulch known properties monitored would allow better assessment potential impact stormwater runoff wood recycling facilities elsevier ltd rights reserved
photosynthetic eukaryotes complex evolutionary history shaped multiple endosymbiosis events required tight coordination organelles rest cell plant ionotropic glutamate receptors iglrs form large superfamily proteins predicted proven non selective cation channel activity regulated broad range amino acids involved different physiological processes sensing resistance fungal infection root pollen tube growth response wounding pathogens present knowledge limited iglrs located plasma membranes however recent studies localized different iglr isoforms mitochondria chloroplasts suggesting possibility play specific role bioenergetic processes work performed comparative analysis glr sequences bacteria various photosynthetic eukaryotes particular novel types selectivity filters bacteria reported adding new examples great diversity glr superfamily highest variability glr sequences found among algal sequences cryptophytes diatoms brown green algae glrs land plants closely related glrs green algae analyzed work glr family underwent great expansion vascular plants among plant glr clade iii includes sequences physcomitrella patens marchantia polymorpha gymnosperms considered ancient clades likely emerged later silico analysis allowed identification sequences putative target organelles sequences predicted localization mitochondria chloroplasts randomly distributed among different type glr suggesting compartment related specific function maintained across species elsevier rights reserved
objectives context pediatric sports injuries epiphyseal apophyseal knee fractures represent rather peculiar lesions frequently involved anatomical area knee peculiar function physis need preserve integrity makes choosing treatment methods employ important objective study assess kind effectiveness suitable treatment apophyseal epiphyseal knee lesions occurring adolescents materials methods treated patients ages diagnosis traumatic knee injury caused sports activities traumatic physeal fractures distal femur proximal tibia anterior tuberosity avulsion intercondylar eminence lesions occurred frequently treatment belonged type lesion closed reduction percutaneous fixation wires screws femoral podalic plaster cast orif wires screws arthroscopic reduction internal fixation using absorbable screws patients given posna questionnaire end follow results follow average years years considered excellent results obtained patients fair patients case result obtained considered poor cases lost follow average posna score end follow early complications recorded following case infection wires days pinning reported compression popliteal neurovascular bundle due displaced tibial physeal fracture discussion since sport childhood adolescence practiced frequently also competitive level kinds fractures children ages occurring often especially male patients sports traumatology knee age group characterized typology injuries particular knowledge anatomy physiology children appropriate diagnostic assessment essential identify appropriate treatment options specific injury nucleus proximal tibial growth plate progressively closes posterior medial side patients years age apophyseal displacement tibial tuberosity always perform exam exclude intra articular physeal fracture
objective compare survival outcomes myositis associated usual interstitial pneumonia uip idiopathic pulmonary fibrosis ipf uip methods adult uip ipf uip patients identified using ctd ipf registries uip cohort included myositis anti synthetase syndrome patients interstitial lung disease manifesting uip high resolution chest lung biopsy revealing uip histology ipf subjects met american thoracic society criteria similarly uip histopathology kaplan meier survival curves compared cumulative pulmonary event free survival event transplant death mauip ipf uip subjects uip biopsy proven uip ipf uip subjects matched age gender baseline forced vital capacity cox proportional hazards ratios compared survival controlling variates results eighty one ipf uip uip subjects identified median cumulative eventfree survival time ipf uip years years respectively cumulative event free survival significantly worse ipf uip uip hazards ratio ipf uip respectively ipf uip event free survival cumulative remained significantly worse uip hazards ratio controlling age interstitial lung disease diagnosis gender ethnicity baseline forced vital capacity respiratory failure common cause death groups sub analysis biopsy proven uip subjects showed similar results conclusion uip patients demonstrated significant survival advantage matched ipf cohort suggesting despite similar histological radiographic findings presentation prognosis mauip superior ipf uip
case study well known method often applied teaching learning mainly graduate level depth implementation method allows using common case study courses semester academic year common case study consistently used since master science planning management civil engineering universitat politecnica valencia goal develop generic competencies well content coordination cohesion step implementation portfolio order improve assessment course competences anyway course provides initial statement explaining additional information required well expected outputs deliverables additional coordination needed order succeed therefore coordination plan define common set contents every course work individualized way every course rubric designed common criteria finally guide indicate steps students follow order solve problem giving clues circumstances guides want show solution problem layout filled student throughout learning process paper also describes contents guides example
background increasing understanding significance early neurodevelopment establishing risk range mental disorders models early aetiology mental disorders complex range potential factors genetic epigenetic environmental influencing neurological psychological development whilst mechanisms fully understood paper provides overview potential biological neurobiological factors might involved method aetiological model presented discussed discussion includes range risk factors mental disorder maternal anxiety disorder presented reviewed example interaction placental epigenetic early parenting factors elevating risk poor neonatal outcome results available evidence points importance utero influences well role early attachment emotional care transgenerational mechanisms impact maternal mental disorder foetal development important models examination early risk maternal anxiety example significant risk factor compromised mental health conclusions development models understanding early origins mental disorder important step elaborating risk reduction strategies comprehensive early identification risk raises possibility preventive interventions
design great infrastructures often complicated presence complex sometimes uncertain geological settings require detailed study geological reference model grm reconstruction purpose however site investigation mainly represented drillholes completed field laboratory tests punctual continuous along project could reveal insufficient especially without sufficient information surface geology useful reconstruction geological reference model cases may accompanied geophysical surveys linear seismic refraction seismic tomography bases surveys act trimming elements geophysical results said occurred design operated design construction management anas road axis sardinia characterized presence long viaduct serra viaduct falling rather complex geological structural situation
agave americana fibers abundant variety tunisia quite important textile potential potential demonstrated studying extraction fibers leaves physical properties fineness density mechanical behavior tensile tests work results mechanical behavior study fibers extracted agave americana plant presented results deal principal mechanical characteristics fibers strain break elasticity modulus rupture facture results permitted situate fibers compared textile fibers materials used technical applications reinforcing composites geotextile order understand mechanical properties fibers correlation study properties already cited fine structure done obtained results showed mechanical properties agave americana fibers closely related individual fibers deformations natural matrix lignin gums linked elementary fibers
paper presents efforts direction teaching computer programming concepts young students kids range years old work innovative attractive romanian primary secondary schools field computer programming authors believe involvement work field could prove beneficial national educational policy consequently turning interest young generations stem oriented careers
background invasive pulmonary aspergillosis ipa fungal infection frequently observed patients immune dysfunction suffering structural lung diseases nevertheless studies assessing ipa combined common respiratory diseases remain scarce particularly regarding immune status patients different structural lung diseases known differently affect patient immune status however mechanisms conferred yet determined thus study aims compare immune status ipa patients structural lung diseases chronic obstructive pulmonary diseases copd interstitial lung disease ild non cystic fibrosis bronchiectasis ncfb methods study performed retrospectively data collected years shanghai pulmonary hospital tongji university included patients whose lower respiratory tract lrt samples tested positive analysis considered blood examinations igg iga igm levels results double positive cells representing cell mediated immunity less abundant ipa patients copd ild ncfb respectively agreement result corticosteroid broad spectrum antibiotic use common individuals copd iga levels indicate humoral immunity lower ipa patients ncfb copd ild respectively conclusions immunity status differs ipa patients different structural lung diseases among ipa patients copd ild ncfb copd lowest cell mediated immunity ncfb lowest humoral immunity
problem discrete time model identification industrial processes time delay investigated iterative separable method proposed solve problem rational transfer function model parameters time delay alternately fixed estimate instrumental variable technique applied guarantee consistent estimation measurement noise noteworthy merit proposed method handle fractional time delay estimation compared existing methods commonly assuming time delay integer multiple sampling interval identifiability analysis time delay addressed correspondingly guidelines provided practical implementation proposed method numerical experimental examples presented illustrate effectiveness proposed method
modern permanent magnet synchronous machines pmsms may also operated regimes significant magnetic saturation occurs classical fundamental wave models incorporate magnetic saturation systematic way mostly heuristic extensions found literature control schemes based models thus often unable achieve given control demands paper proposes flatness based torque control strategy saturated surface mounted pmsm different existing works magnetic saturation considered thorough physically consistent way based calibrated magnetic equivalent circuit model pmsm simplified model suitable flatness based controller design derived proposed dof control scheme inherently accounts mutual coupling phase windings furthermore time varying controller gains obtained pole placement technique contrast majority controllers used pmsm control proposed control scheme formulated stator fixed reference frame hence coordinate transformation necessary flatness based torque controller implemented experimental test bench accelerated run pmsm four times rated torque performed highlight feasibility proposed approach finally flatness based torque controller compared common vector control implementation based model motor
applicable highway light weight railway suspension bridge suspension bridge flexible stiffness small based existing design research reasonable functional stiffness index long span railway suspension bridge presented factors include side span mid span ratio sag span ratio depth span ratio width span ratio analyzed compared factors highway suspension bridge suitable factors railway suspension bridge summarized finally contribution different structure system stiffness exiting problem discussed could reference designers research
department veterans affairs committed preventing ending homelessness among veterans estimates incidence veteran homelessness prospective studies identify predictors homelessness study examines year incidence homelessness among veterans seen specialty mental health clinics identified sociodemographic clinical predictors homelessness using retrospective cohort study design data extracted medical records veterans referred anxiety posttraumatic stress disorder clinics across facilities followed year referral homeless incidence defined new use homeless services documented international classification diseases rev lack housing code year total sample women men experienced homelessness within year referral specialty mental health care veterans unmarried diagnosed drug use disorder twice likely become homeless black annual incomes less one half times likely become homeless together findings suggest notable important percentage veterans seen specialty mental health clinics newly experience homelessness annually monitoring early signs housing vulnerability preventing homelessness vulnerable treatment engaged population may important efforts end veteran homelessness
work present interactive collaborative object manipulation system using shelf mobile devices coupled augmented reality technology allows multiple users collaborate concurrently scene user interested participating collaboration uses mobile device running android desktop laptop working tandem scene visualized user desktop system changes scene viewpoint changes object manipulations performed using mobile device system leverages user knowledge common tasks performed current mobile devices pinching zooming swiping one two fingers object rotation press hold seconds object translation see video built prototype system maze style applied informal user study three experienced researchers users carry cube three square rings along maze resume diagnosed working collaborative way users better easier individual one user registered minutes late individual experience comparing teamwork may happen two player team shared information functions multi perspective view task
background melandrii herba medicinal plant used korea treatment bacterial fungal infection however safety toxicity melandrii herba yet established therefore investigated acute subacute toxicity ethanolic extract melandrii herba mhee crl sprague dawley rats cytotoxicity mhee vitro methods study acute toxicity rats treated mhee single doses administered oral gavage body weight clinical signs mortality observed dosing study subacute toxicity rats treated mhee doses administered day gavage weeks measured clinical signs mortality gross pathological findings body organ weights food consumption serum biochemistry conducted hematology urinalysis cytotoxicity mhee assayed measuring viability prostate cell lines including normal prostate stromal wpmy normal prostate epithelial rwpe benign prostatic hyperplasia epithelial bph cells various concentrations mhee vitro results single oral doses mhee caused significant difference rat clinical signs mortality body weight lethal dose mhee considered daily oral doses mhee weeks result significant changes rat mortality gross pathological findings relative organ weights food consumption hematology serum biochemistry urinalysis mhee day salivation increased male female rats however salivation caused mhee treatment accompanied pathological changes body weight gross pathological findings considered salivation minor symptom therefore adverse effects seen day less mhee showed cytotoxic effects either normal prostate benign prostatic hyperplasia cell lines conclusions administration mhee crl spradgue dawley rats nontoxic safe least month
explored cross sectional relationships beta amyloid beta inferior temporal tau deposition ift tau cognitive performance whether cognitive reserve modifies associations studied participants classified groups clinically normal mild cognitive impairment mci alzheimer disease dementia amnart served proxy cognitive performance assessed using mmse separate linear regression models predicting mmse examined interactions global beta ift tau across participants within group alone whole sample interaction ift tau significant higher participants elevated ift tau better mmse scores compared low participants similar levels ift tau interaction beta status reach significance cross sectional interactions among beta ift tau observed mmse findings imply may protective early processes enable individuals remain cognitively stable despite elevated tau beta burden
inherent broadcast capabilities satellites make attractive solution delivery multimedia services mobile users third generation networks reliable delivery content hostile land mobile satellite channel one key technical system requirements addressed different protocol layers paper focus attention two mechanisms provide non perfect reliability packet level forward error correction technique transport layer power scheduling function satellite radio interface rely end end simulation platform order assess performance gain achieved two mechanisms providing time clear indications achievable benefit system level two mechanisms act ordination rather isolation
purpose review broad spectrum coronary artery anomalies cardiologists may encounter either incidentally evaluation cardiac symptoms anomalies include anomalous coronary arteries arising opposite sinus valsalva acaos coronary fistulae coronary artery aneurysms manuscript outlines unique features diagnostic characteristics treatment considerations lesions recent findings intravenous ultrasound ivus computed tomographic angiography cta magnetic resonance imaging mri becoming sophisticated increasingly used facilitate optimal treatment approach coronary anomalies summary wide variety coronary artery anomalies clinical ramifications range benign potentially fatal coronary anomalies often complex anatomy require advanced imaging modalities comprehensive characterization due heterogeneity lesion characteristics outcomes physicians consider clinical imaging features create individualized management plans along referral adult congenital heart disease centers
hydraulic engineering visualization simulation increases predictability engineering design work engineering design construction reduce costs reasonable arrangements construction projects important guiding significance paper studies three dimensional visual simulation based major water conservancy projects establishment consolidation method describes terrain surface features digital models finally introduced interact three dimensional digital model actual project develop scientific intuitive vividly show construction large water conservancy visualization simulation system proposed water project data acquisition simulation system structure composition data management simulation virtual reality four parts provide basis construction management decisions
since marital distress multidimensional phenomenon research efforts directed identifying meaningful groups individuals common characteristics based dissatisfaction various relationship domains important addition important examine association among white majority group couples also among ethnic groups mexican american couples may differ terms cultural values customs latent profile analysis lpa caucasian mexican american newlyweds self reported marital distress identified four groups groups showed continuum dissatisfaction well varying degrees differences partners views traditional versus nontraditional gender roles classes resulting lpa related individuals mental health individuals found groups higher distress also experienced higher levels anxiety depression individuals found groups lower distress although research clearly needed among larger diverse samples present findings may useful field marriage family therapy may guide prevention intervention efforts field marital distress mental health
study aimed examine individual behavioural home environmental factors associated frequency consumption fruit vegetables energy dense snacks among adolescents adolescents aged years boys completed paper based questionnaire class time included food frequency questionnaire assessing consumption fruit vegetables energy dense snacks items assessing habits self efficacy eating television eating parents parenting practices home availability accessibility foods multiple linear regression analyses showed eating fruit vegetables watching home availability accessibility fruit vegetables positively associated frequency fruit consumption vegetable consumption home accessibility snack foods negatively associated frequency fruit consumption habit eating snack foods front eating snack foods watching home availability snacks positively associated frequency snack consumption study highlighted importance healthy home environment promoting fruit vegetable intake early adolescents also suggests snacking viewing occurs could good opportunity promoting fruit vegetable intake findings likely useful supporting development multi faceted interventions aid knowing advice give parents help help young adolescents develop maintain healthy eating habits authors published elsevier ltd
functional protein homeostasis essential maintenance normal cellular physiology cell growth cell survival proteasome inhibition cancer cells disturb protein homeostasis way synthetic proteasome inhibitors like bortezomib may selectively kill myeloma cells solid cancer cells appear respond less bortezomib may part due rescue mechanism unfolded protein response endoplasmic reticulum stress mechanism leads temporary shutdown protein biosynthesis translational level show proteasome inhibition bortezomib may also interfere general protein biosynthesis already stage nucleolar ribosome biogenesis ultrastructural analysis revealed bortezomib induces conspicuous changes cytoplasmic morphology also pronounced morphological changes nucleolar ultrastructure associated accumulation transcription factor atf nucleolar sites stress induced intra nucleolar atf accumulation observed cancer cells dose time dependent manner ultrastructural studies revealed atf preferentially localized inside dense fibrillar granular component nucleoli furthermore bortezomib affected number nucleoli also volume distribution nucleolar components localization atf granular component nucleoli together association nascent rna transcripts cells undergoing proteotoxic cell stress could suggest new function atf cell stress management elsevier gmbh rights reserved
three phase free piston type double acting stirling engine model proposed validated using experimental results modeling strategy based combination two sub models global thermal model engine deal heat sources coupling detailed equivalent electrical network model accounts gas mechanical dynamic physics engine derived features amplitude frequency compression expansion powers finally obtained model experimentally validated prototype free piston stirling engine mean error amplitude frequency internal temperatures compression expansion powers model considered accurate enough predict performances optimization purpose numerical analysis performed selecting three following critical parameters dead volume chambers natural frequency mechanical oscillators iii thermal conduction hot cold sides smaller dead volume large oscillating mass high insulation sought maximizing performances pressurization bar theoretical useful power reach conservative modification existing prototype moreover energy exergy analyses highlight main losses system thermal leakage gas spring hysteresis well heat transfer viscous dissipation heat exchangers elsevier ltd rights reserved
early years china civil war communist army leadership sought refuge nationalist troops remote western district fujian province known tingzhou three years leaders fledgling communist party including mao zedong zhou enlai occupied city christian hospital church importance period ccp historical lore buildings today national level protected sites promoted red tourism junkets visit sites central revolution despite close connection ccp history church building county town today functioning religious site registered church county town created interesting dynamic local state church sides hope capitalise historic significance christian property article providing brief background tingzhou church suggests case reflects new willingness china acknowledge promote christian history furthermore article argues churches becoming increasingly adept realising value state sees heritage use negotiations governing authorities
objective clarify clonality distinct multisegmental main duct intraductal papillary mucinous neoplasms ipmns using microarray analysis background ipmns represent pancreatic ductal cell field defect causes multiple occurrences lesions addtion speculated ipmns display features monoclonal skip progression methods total rna extracted fresh frozen tissue samples metachronous ipmns nonneoplastic pancreas tissue pancreas two individuals whole human genome microarray analysis performed formalin fixed paraffin embedded tissue specimens distinct ipmns collected patients genomic dna extracted gnas kras mutational status investigated immunohistochemical analysis performed validate expression pattern indicated proteins results microarray analysis revealed metachronous ipmns individual displayed pair wise correlation coefficients contrast ipmns histological grade different individuals displayed coefficients scatter plot analysis revealed metachronous ipmns individual displayed closer linear relationship furthermore heat map hierarchical cluster analyses revealed metachronous ipmns individual classified branch gene expression patterns similar gnas kras mutational statuses distinct ipmns consistent immunohistochemical assessment five specific proteins demonstrated expression pattern two lesions observed samples conclusions findings using molecular analyses indicate mdipmns might display features monoclonal skip progression
background although management invasive fungal infection ifi improved number controversies persist regarding approach invasive fungal infection non neutropenic medical ward patients aims identify essential clinical knowledge elaborate set recommendations high level consensus necessary management ifi non neutropenic medical ward patients methods prospective spanish questionnaire measures consensus delphi technique anonymously answered mailed multidisciplinary national experts specialists intensivists anesthesiologists microbiologists pharmacologists specialists infectious diseases ifi belonging six scientific national societies responded five questions prepared coordination group thorough review literature published last years category selected level agreement among experts category equal greater second round specialists attended face face meeting held extracting recommendations chosen topics validated pre selected recommendations derived algorithm results following recommendations validated included algorithm several elements identified risk factors invasive candidiasis non hematologic medical patients agreement use colonization index decide whether prescribing early antifungal treatment stable patients shock sepsis evident focus risk factors agreement use candida score decide whether prescribing early antifungal treatment stable patients shock sepsis evident focus risk factors agreement initiating early antifungal treatment stable patients shock colonization index sepsis evident focus risk factors agreement performance additional procedures stable patients shock sepsis evident focus risk factors without colonization index high degree suspicion conclusions based expert recommendations algorithm management nonneutropenic medical patients constructed validated algorithm may useful support bedside prescription asociacion espanola micologia published elsevier espana rights reserved
introduction although risk factors lung cancer well documented whether previous radiation therapy treat breast cancer increases incidence second primary lung cancer remains unclear determined overall incidence second primary lung cancer previous clinical stages methods analysis longitudinal health insurance database individuals randomly enrolled cohort analysis women newly diagnosed invasive aged years older without types malignancy follow periods enrolled allocated non groups age comorbidities insurance premium urbanization level location date event hospital care level analyzed hazard ratios parameters calculated cox regression analysis results total individuals met inclusion criteria including patients underwent lung cancer developed contrast lung cancer diagnosed four individuals non group followup period cox regression analysis showed adjusted hazard ratio times higher group non group individuals previous conclusions incidence second primary lung cancer significantly higher group non group individuals previous patients treated extensively surveyed assess incidence subsequent lung cancer international association study lung cancer published elsevier inc rights reserved
congenital cardiac anomalies common anomalies estimated incidence per live births proper perinatal neonatal management dependent upon accurate prenatal diagnosis approximately foetuses cardiac abnormalities identified risk factors hence anomalies occur pregnancies without prenatal risk factors foetal echocardiography allows prenatal diagnosis congenital heart disease serves routine screening tool congenital heart defects advanced technology allowed accurate early detection cardiac abnormalities also improved care outcome selected foetuses severe cardiac malformations arrhythmias also identify patients utero cardiac interventions prenatal diagnosis congenital heart disease allowed better counseling preparation families regarding expected prenatal development foetus well anticipated postnatal management strategy prognosis
transient receptor potential melastatin trpm member protein coupled receptor superfamily novel dual function protein possesses ion channel adenosine diphos phatase ribose adpr hydrolase function trpm involved signaling various cells endogenous redox sensor oxidative stress reactive oxygen species contributes cytokine production insulin release motility entry dependent cellular reactions endothelial hyper permeability apoptosis wide expression trpm might render potentially significant therapeutic target pathological settings including cardiovascular neurodegenerative diseases great relevance drug design feed additives industries discuss trpm gene structure function variants well activators inhibitors provide peptide drug design modulation oxidative stress
background hereditary angioedema hae rare disease characterized esterase inhibitor inh deficiency resulting periodic attacks acute edema life threatening occur upper airway head head comparisons different treatment options acute hae attacks available immediate symptom relief critical potentially life threatening laryngeal attacks important determine treatment option provides optimal treatment response objective review compare data clinical studies evaluated efficacy safety treatments laryngeal hae attacks methods conducted indirect comparison clinical outcomes prospective studies treatment acute laryngeal attacks plasma derived inh concentrate pdc inh fixed doses body weight adjusted dose recombinant inh concentrate fixed dose body weight adjusted dose icatibant ecallantide comparisons included time onset symptom relief need dosing emergency procedures results median time onset symptom relief ranged min approximately shortest body weight adjusted doses pdc inh proportion laryngeal attacks dosing ranged dosing needed treatment single body weight adjusted dose pdc inh attacks conclusions available data suggest among different hae treatments body weight adjusted pdc inh provides reliable treatment response treatment laryngeal hae attacks authors published elsevier inc
purpose post conflict housing reconstruction crucial development peacekeeping however success hindered number problems related lack addressing housing needs purpose paper explore housing needs effectively managed post conflict housing reconstruction sri lanka design methodology approach using grounded theory method research strategy unstructured interviews conducted policy makers practitioners beneficiaries academics sri lanka data analysed using open axial selective coding develop theoretical framework findings study reveals challenges contributing factors strategies addressing housing needs accessibility habitability affordability location facilities cultural considerations security land tenure also identifies gaps recommendations paper establishes links presents theoretical framework formanaging housing needs effectively post conflict housing reconstruction sri lanka practical implications research enhances success post conflict housing reconstruction addressing housing needs effectively contributes sustainable housing development conflicts originality value study combines literature five main areas conflicts post conflict post conflict reconstruction post conflict housing reconstruction housing needs provides better understanding housing needs managed post conflict housing reconstruction developing countries based empirical evidence
construction management practice oriented field course content needs include many elements practice many new developments take place new technologies emerge necessity redefining working dynamics among project stakeholders necessitates construction educators constantly evaluate reorganize scope courses situation justifies necessity bringing research findings classroom paper exemplifies research findings brought major construction course project management course university texas san antonio covers broad range topics fundamental concepts management roles construction industry project delivery contract methods detailed analysis administration different phases construction project demand sustainable projects growing delivery method requires lots input wide range experts far set accepted method sustainable building project delivery coverage project delivery methods instructor brings characteristics sustainable projects comparative analysis made conventional sustainable projects phases sustainable projects include many additional elements early involvement defined tasks phases conventional projects recent research study accomplished author highlights differentiating aspects conventional projects sustainable projects findings obtained research conducted major national firms incorporated future lectures research explored sustainable delivery practices major national construction firms used case study complement theoretical part lecture impact students learning identified students appreciate value knowledge brought outside textbook especially research original accomplished course instructor approach taken example various topics recent aec industry
describe new set interaction techniques allow users interact physical objects augmented reality previously operate smart device physical touch generally needed graphical interface normally involved become limitations prevent user operating device reach operating multiple devices ubii ubiquitous interface interaction integrated interface system connects network smart devices together allows users interact physical objects using hand gestures user wears smart glass displays user interface augmented reality view hand gestures captured smart glass upon recognizing right gesture input ubii communicate connected smart devices complete designated operations ubii supports common inter device operations file transfer printing projecting well device pairing improve overall performance system implement computation offloading perform image processing computation user test shows ubii easy use intuitive traditional user interfaces ubii shortens operation time various tasks involving operating physical devices novel interaction paradigm attains seamless interaction physical digital worlds
paper presents systematic solution kinematics planar mechanism aspect assur groups planar mechanism decomposed assur groups detailed calculating order assur groups unknown solve problem first decomposed assur groups classified three types according calculability lays foundation establishment automatic solving algorithm decomposed assur groups second data structure assur group presented enables automatic solving algorithm input output parameters assur group decomposed assur groups stored component stack parameters stored parameter stacks automatic algorithm detect identification flags assur group component stack corresponding parameters parameter stacks order decide assur group calculable one solved afterward proposed systematic solution able generate automatic solving order assur groups planar mechanism allows adding modifying removing assur groups time two planar mechanisms given examples show detailed process proposed systematic solution
due cost effectiveness rainwater harvesting rwh systems practicing already rural parts bangladesh urban areas paper aimed evaluate potentiality rwh systems south agrabad chittagong city average annual precipitation experiencing water scarcity urban flooding year adopted approach analytic hierarchy process amp based multicriteria decision analysis technique evaluation criteria roof area slope drainage density runoff coefficient geospatial hydrologic modeling extension supported hydrologic model viz hec hms used simulate precipitation runoff process model outcomes showed rwh potentiality could minimize stagnant storm water supplementing city water supply annually liter person day assigning suitable weightage evaluation criteria associated features arcgis study area reasonably divided three potential zones good moderate poor covering total area respectively thus envisaged ahp using hec hms could provide important guidance decision supporting system urban areas also wide sub basin basin context crown copyright published elsevier rights reserved
paper study deterministic blind identification multiple channel state space models common unknown input using measured output signals perturbed additive white noise sequences different traditional blind identification problems considered system autoregressive system rather fir system hence concerned identification problem challenging possibly wider scope application two blind identification methods presented multi channel autoregressive systems cross relation identification method developed exploiting mutual references among different channels requires least three channel systems square stably invertible transfer matrices moreover general subspace identification method developed two channel systems sufficient blind identification however requires additive noises identical variances transfer matrices transmission zeros finally numerical simulations carried demonstrate performance proposed identification algorithms elsevier ltd rights reserved
background mucormycosis uncommon life threatening fungal infection major risk factors infection include uncontrolled diabetes mellitus prolonged steroid therapy persistent neutropenia hematological malignancies autoimmune disorders trauma burns surgical wounds objectives current study aimed determine epidemiology treatment outcome mucormycosis khuzestan province southwest iran methods cross sectional study performed period years april march razi hospital ahvaz southwest iran years demographic data laboratory data clinical features antifungal treatment need surgical debridement outcome collected data summarized using descriptive statistical methods analyzed spss version software results study included patients biopsy proven diagnosis mucormycosis regarding findings mean age years eighty five percent patients uncontrolled diabetes mellitus findings showed cases received amphotericin surgical debridement performed patients prevalent season mucormycosis winter conclusions prognosis patients underwent surgery medical therapy significantly better medical therapy alone patient survival
channel fully depleted silicon insulator fdsoi transistors completely isolated substrate via buried oxide box sides shallow trench isolations results high thermal resistance increases reduction channel length paper proposed compact model geometry temperature dependence fdsoi transistors model validated experimental technology computer aided design tcad data proposed model implemented independent multi gate model bsim img fdsoi transistors elsevier ltd rights reserved
owing ubiquity web applications modern computing server software delivers applications attractive attack vector would malicious actors cyberspace recently moving target defense mtd strategies grown popularity computer security community ability enhance resilience force attackers uncharacteristic behavior mtd prototype discussed paper acts proactive defense strategy offers increased protection attacker ability probe exploit vulnerable web server software testing shows web server diversity mtd reduces ability exploit vulnerabilities web server reduces impacts successfully exploited vulnerabilities increases resilience protected application
study developed examined feasibility model based system identification approach cardiovascular disease diagnosis basic premise approach may possible diagnose cardiovascular disease disease induced alterations arterial mechanical properties manifested proximal distal arterial blood pressure waveforms first individualizes lumped parameter model wave propagation reflection artery using measurement proximal distal arterial blood pressure waveforms employs diagnosis logic form disease specific patterns model parameters referred alpha beta pulse transit time longitudinal change parameters used diagnose presence peripheral artery disease arterial stiffening illustrated feasibility proposed approach testing full scale silico arterial tree simulation results showed approach exhibited superior sensitivity ankle brachial index convenience carotid femoral pulse wave velocity model parameters responded changes peripheral artery disease arterial blockage whereas change ankle brachial index parameters responded changes arterial stiffening pulse transit time changed together development convenient techniques measurement arterial blood pressure waveforms proposed approach may evolve viable alternative state art techniques cardiovascular disease diagnosis
paper investigate nonlinear system describes marginally unstable baroclinic wave packets geophysical fluid based symbolic computation hirota method bright one two soliton solutions system derived propagation collisions solitons graphically shown discussed beta reflects collision wave packet mean flow measures state basic flow group velocity gamma gamma observed affect amplitudes solitons alpha influence solitons traveling directions virtue generalized darboux transformation first second order rogue wave solutions derived properties first second order rogue waves graphically presented analyzed first order rogue waves shown figures alpha effects amplitude wave packet increase alpha amplitude quantity measuring correction basic flow decreases beta chosen differently keep shapes invariant value alpha increasing amplitudes become larger second order rogue wave presented observe alpha increasing amplitude decreases effects collision features alter value beta changing make value gamma larger amplitudes increase
child maltreatment adverse childhood experiences adversely influence population health socioeconomic outcomes knowledge risk factors child maltreatment used identify children risk may represent opportunities prevention examined range possible child parent family risk factors child maltreatment prospective year population based birth cohort australians physical abuse sexual abuse emotional abuse neglect witnessing domestic violence recorded retrospectively early adulthood potential risk factors collected prospectively childhood reported retrospectively associations estimated using bivariate multivariate logistic regressions combined cumulative risk scores higher levels economic disadvantage poor parental mental health substance use social instability strongly associated increased risk child maltreatment indicators child health displayed mixed associations infant temperament uncorrelated maltreatment differences observed across types maltreatment risk profiles generally similar multivariate analyses nine independent risk factors identified including potentially modifiable economic disadvantage parental substance use problems risk maltreatment increased exponentially number risk factors experienced prevalence maltreatment highest risk groups exceeding cumulative risk score based independent risk factors allowed identification individuals high risk maltreatment score incorporated significant risk protective factors provided better identification low risk individuals elsevier ltd rights reserved
background antisocial personality disorder aspd borderline personality disorder bpd share genetic environmental risk factors little known temporal stability etiological factors adulthood method dsm criteria aspd bpd assessed using structured interviews norwegian twins early adulthood approximately years later longitudinal biometric models used analyze number endorsed criteria results mean criterion count aspd bpd decreased respectively early middle adulthood rank order stability aspd bpd best fitting longitudinal twin model included genetic individual specific environmental factors genetic effects shared aspd bpd specific disorder remained completely stable unique environmental effects however changed substantially correlation across time shared effects respectively specific aspd bpd genetic effects accounted stability time aspd bpd respectively genetic environmental correlations aspd bpd respectively time points conclusion aspd bpd traits moderately stable early middle adulthood mostly due genetic risk factors change year assessment period environmental risk factors mostly transient appear main source phenotypic change genetic liability factors large extent shared aspd bpd
growth recovery lines also known growth arrest lines transverse radiodense metaphyseal bands develop due temporary arrest endochondral ossification caused local systemic insults determine growth recovery lines common infants high risk versus low risk abuse reports american college radiology compliant skeletal surveys reviewed clinical records infants low risk abuse skull fracture without significant intracranial injury history fall clinical determination low risk child protection team social work assessment infants high risk significant intracranial injury retinal hemorrhages skeletal injuries clinical determination high risk low risk infants mean months range months high risk infants mean months range months two blinded radiologists independently evaluated skeletal survey radiographs knees lower legs presence least one growth recovery line growth recovery lines scored probably present definitely present prevalence low risk group standard deviation reader reader reader reader high risk group odds ratio growth recovery lines encountered significantly higher rate infants high risk low risk abuse suggests abused infants prone temporary disturbance endochondral ossification result episodic physiological stresses
objectivesoffspring depressed parents increased risk psychiatric disorders although bipolar disorder major depressive disorder mdd found families clear whether transmission offspring mdd tends occur parents mood disorder subtype primary hypothesis offspring parents would increased risk comorbid disorders common anxiety substance use relative offspring parents mdd offspring parents versus mdd also hypothesized greater risk externalizing disorders conduct disorder attention deficit hyperactivity disorder antisocial personality disorder methodsparents mood disorders offspring studied adult offspring administered structured clinical interview dsm axis disorders establish presence psychopathology offspring aged years assessed using school aged schedule affective disorders schizophrenia present lifetime version parents children age ten completed child behavioral checklist data examined using cox proportional hazard regression resultsthere difference hazard mood disorders offspring parents compared offspring parents mdd however number parent offspring characteristics increased risk mood anxiety externalizing substance use disorders offspring including self reported childhood abuse parent offspring offspring impulsive aggression age onset parental mood disorder conclusionsmood disorders highly familial finding appears independent whether parent condition unipolar bipolar suggesting considerable overlap heritability mdd although parental characteristics limited influence risk offspring psychopathology reported childhood adversity parent child harbinger negative outcomes risk factors extend previous findings consistent diathesis stress conceptualizations
paper presents efficient approach optimal designs two analog circuits namely complementary metal oxide semiconductor two stage comparator channel metal oxide semiconductor input driver channel input folded cascode operational amplifier using recently proposed meta heuristic based optimization algorithm named colliding bodies optimization cbo multi agent algorithm depend upon internal control parameter making algorithm extremely simple main objective paper optimize metal oxide semiconductor mos transistors sizes using cbo order reduce areas occupied circuits get better performance parameters circuits simulation program integrated circuit emphasis simulation carried using optimal values mos transistors sizes design parameters validate cbo based design satisfying desired specifications simulation results demonstrate design specifications closely met required functionalities achieved simulation results also confirm cbo based approach superior algorithms terms mos area performance parameters like gain power dissipation etc examples considered copyright john wiley sons ltd
characterizing ubiquitous systems privacy issues gender age goal selected two ubiquitous systems wearable system google glass embedded context system smart office online survey participants included questions people perceive privacy issues related use two different ubiquitous systems conducted results show google glass generates higher degree concern smart office female participants tend worried male independently ubiquitous system considered finally youngest participants years old concerned privacy threats unexpected
recent technological advances enabled dna methylation assayed single cell resolution however current protocols limited incomplete cpg coverage hence methods predict missing methylation states critical enable genome wide analyses report deepcpg computational approach based deep neural networks predict methylation states single cells evaluate deepcpg single cell methylation data five cell types generated using alternative sequencing protocols deepcpg yields substantially accurate predictions previous methods additionally show model parameters interpreted thereby providing insights sequence composition affects methylation variability
image definition influenced alignment errors mirrors optical system consisting hyperbolic parabolic ellipse mirrors major factors alignment errors gravity wind loads heat exchange optical systems like ground based telescopes vibration temperature gradient systems like space telescopes larger telescopes sensitive error sources becomes concerns researchers alignment errors mirrors must corrected time keep systems working best condition order solve problem many methods proposed based detection wave front errors using wave front sensors like hartmann shack however wave front sensors may used cause optical systems complicated example multi fields must tested telescope working one hand wave front sensor used must moved around imaging plane hand wave front sensors used system must complicated new method discussed alignment error correction evaluating quality spot diagrams based using stochastic parallel gradient descent spgd algorithm method considers performance metric like spot diagram radius function control parameters uses spgd optimization algorithm improve performance metric control parameters include positions mirrors iteration process must used right way control position parameters considered problem may come positions spot diagrams may influenced iteration furthermore spot diagrams probably disappear detectors radii spot diagrams correct better way put forward combination center tilt mirrors way ensures position error produced center tilt compensated formula provided paper give relationship based analysis optical system designed verify conclusion spgd algorithm achieved computer programming position mirror controlled hexapod firstly problem verified spot diagram disappear detector normal iteration process new way implemented iteration process spot diagram always center detectors order prove feasibility method three different alignment errors tested give airy disk finally experiment provide reference engineering practice
objective fewer half women urinary incontinence seek care condition objective qualitatively assess themes surrounding treatment seeking behaviors methods conducted focus groups women using purposive sampling stratified racial ethnic group white black latina frequency sessions transcribed coded common themes comparative thematic analysis used describe similarities differences among groups results total white black latina community dwelling women participated focus groups differences treatment seeking themes groups different frequency however certain themes emerged comparing racial ethnic groups women groups shared experiences embarrassment isolation impediments care seeking white black women described discussions close friends family led normalization symptoms prevented care seeking latina women maintained secrecy reported longest delays seeking care women articulated higher likelihood seeking care knowledge treatment options white women likely seek related knowledge compared black latina women physician communication barriers identified groups conclusions despite similar experiences different perceptions care seeking among white black latina women culturally relevant educational resources focus range treatment options may improve knowledge thus improve care seeking behaviors women
accurate reliable identification damage modern engineered structures essential timely corrective measures vibration based damage prediction studied extensively virtue global damage detection ability simplicity practical implementation however due noise damping influences accuracy method inhibited direct peak detection dpd utilized determine resonant frequency shifts research investigates alternative method detect frequency shifts caused structural damage based utilization strongly nonlinear bifurcation phenomena bistable electrical circuits coupled piezoelectric transducers integrated structure shown frequency shift predictions proposed approach significantly less susceptible error dpd realistic noise damping levels distort shifting resonance peaks implemented alongside adaptive piezoelectric circuitry tunable inductance new method yields damage location severity identification significantly robust accurate results obtained following dpd approach
background research shows evidence importance physical emotional closeness infant parent infant parent dyad less known parents experience emotional closeness infants neonatal unit aim study methods qualitative study using salutogenic approach focus positive health wellbeing undertaken three nus one sweden england finland emotional closeness form devised asked parents describe moments situations felt emotionally close infant data parents preterm infants analyzed using thematic networks analysis results global theme pathways emotional closeness emerged data set concept related emotional physical cognitive social influences led feelings emotional closeness parents infants five underpinning organising themes relate embodied recognition power physical closeness reassurance contributing infant wellness understanding present past feeling engaged day day spending time bonding family conclusion findings generate important insights parents feel emotionally close knowledge contributes increased awareness support parents premature infants form positive loving relationships infants health care staff create climate parents emotions emotional journey individually supported
food calorie restriction induces several physiological changes including weight loss metabolic adaptations mineral hormonal changes however effects aldosterone steroidogenesis zona glomerulosa cells elucidated therefore present study designed investigate effects aldosterone secretion involved mechanisms ovariectomized ovx rats ovx rats divided libitum fed control groups rats exhibited decreased body weight water intake urine flow sodium excretion increased plasma aldosterone comparison control rats elevated basal angiotensin stimulated aldosterone secretion cells conversions hydroxy cholesterol pregnenolone corticosterone aldosterone cells group greater control group group higher protein expression steroidogenic acute regulatory star protein cells however different protein expression cytochrome side chain cleavage enzyme pscc cells control groups summary increased activities pscc aldosterone synthase well protein expression star protein cells involved effects aldosterone steroidogenesis ovx rats also suggest increase aldosterone might associated anti diuresis antinatriuresis group results helpful understanding role aldosterone physiological adaptation renal sodium conservation
article presents core elements cross platform tactile capabilities interface tci humanoid arms aim interface reduce cost developing humanoid robot capabilities supporting reuse cross platform deployment article presents comparative analysis existing robot middleware frameworks well technical details tci framework builds existing yarp platform currently tci framework includes robot arm actuators robot skin sensors presents hardware platform independent manner making possible write robot control software executed different robots tci frameworks tci framework supports multiple humanoid platforms article also presents case study cross platform implementation set tactile protective withdrawal reflexes realized nao icub humanoid robot platforms using high level source code
idiopathic pulmonary fibrosis ipf severe progressive irreversible lung disease novel antifibrotic drugs slow disease progression available however many issues regarding patient management remain unanswered choice available drugs use particular subgroups clinical situations time treatment onset termination combination switch nonpharma cologic management guide swiss respiratory physicians evolving field still characterized numerous areas uncertainty swiss working group interstitial rare lung diseases swiss respiratory society provides position paper diagnosis treatment ipf karger basel
breathing vital rhythmic behavior generated hindbrain neuronal circuitry including prebotzinger complex network prebotc controls inspiration emergence prebotc network activity prenatal development described little known regarding inspiratory neurons expressing pacemaker properties embryonic stages combined calcium imaging electrophysiological recordings mouse embryo brainstem slices together computational modeling reveal existence heterogeneous pacemaker oscillatory properties relying distinct combinations burst generating nap conductances respective proportion different inspiratory pacemaker subtypes changes prenatal development concomitantly network rhythmogenesis switches purely nap dependent mechanism combined pacemaker network driven process results provide first description pacemaker bursting properties embryonic prebotc neurons indicate network rhythmogenesis undergoes important changes prenatal development alterations circuit properties biophysical characteristics pacemaker neurons
fundamental ethical issues regarding ambient intelligence concern conditions ethical discourse identity acting individual awareness sphere individual act finally individual choice necessary responsibility augmented reality exacerbates problem loss resistance horizon characterize german term wirklichkeit means hyletic social ideal resistance shape world horizon connected systems guarantees wirklichkeit real concrete given thing always possibility misjudging perception confronted loss horizon act old paradigm embedded technology coming critical point smart systems shape world without possibility control guide shaping autonomous systems capacity incapacitate user
glioma rare brain tumour poor prognosis search modifiable factors intense reviewed literature concerning risk factors glioma obtained case control designed epidemiological studies order discuss influence methodology observed results reviewing association three exposures medical radiation exogenous hormone use allergy critically appraised evidence case control cohort studies medical radiation hormone replacement therapy hrt questionnaire based case control studies appeared show inverse association whereas nested case control cohort studies showed association allergies inverse association observed irrespective study design recommend questionnaire based case control design placed lower hierarchy studies establishing cause effect diseases glioma suggest state art case control study minimum accompanied extensive validation exposure assessment methods representativeness study sample regard exposures interest otherwise studies regarded hypothesis testing hypothesis generating consider holds true questionnaire based case control studies cancer chronic diseases although perhaps extent exposure outcome combination
scope paper present systematic versatile method minimal computational requirements incorporates use new electromagnetic bandgap ebg structures stealth technology grounded structures used ensure zero transmittance resulting angle independence incident radiation possible future realistic scenario simulated experimentally examined metallic plane fully covered ebg structures monostatic radar cross section measured varying angle incidence degrees degrees observed worst case scenario reduction monostatic radar cross section rcs almost finally verify idea rcs metallic cube also fully covered ebg structures examined assets proposed concept applied design different patterns appear potentially beneficial various electromagnetic interference electromagnetic compatibility configurations
article investigates risk cost overruns underruns occurring construction onshore offshore wind farms commissioned countries total projects required billion investment reached installed capacity use original dataset test six hypotheses construction cost overruns related technological learning fiscal control iii economies scale configuration regulation markets manufacturing experience find across entire dataset mean cost escalation per project million per windfarm although projects within sample exhibit cost overruns majority onshore wind farms exhibit cost underruns offshore wind farms results larger spread interestingly significant relationship exists size total per individual turbine capacity windfarm severity cost overrun nonetheless indication risk increases larger wind farms greater distances offshore using new types turbines foundations overall mean cost escalation onshore projects offshore projects amounts much lower energy infrastructure copyright john wiley sons ltd
constrained control unmanned aerial vehicles uavs challenging task due nonlinear underactuacted dynamics brief focuses position control quadrotor uav state input constraints using inner outer loop control structure outer loop generates saturated thrust reference roll pitch angles inner loop designed follow reference angles using traditional pid controller assuming perfect inner loop tracking outer loop nested saturation controller guarantees global asymptotic stability output regulation tracking effect nonideal inner loop tracking closed loop stability analyzed proposed method experimentally validated indoor quadrotor platform
background biologic therapies effective costly conventional therapies treating psoriatic arthritis objectives evaluate cost efficacy etanercept adalimumab golimumab therapies treating active psoriatic arthritis taiwanese setting methods conducted meta analysis randomized placebo controlled trials calculate incremental efficacy etanercept adalimumab golimumab respectively achieving psoriatic arthritis response criteria psarc improvement american college rheumatology score acr base best worst case incremental cost effectiveness ratios icers one subject achieve psarc acr calculated results annual icer per psarc responder best scenario worst scenario best scenario worst scenario best scenario worst scenario etanercept adalimumab golimumab respectively annual icer per acr responder best scenario worst scenario best scenario worst scenario best scenario worst scenario etanercept adalimumab golimumab respectively conclusions taiwanese setting etanercept lowest annual costs per psarc acr responder adalimumab highest annual costs per psarc acr responder
sediment grains bedrock alluvial river deposited within adjacent sediment patch isolated grains bedrock surface previous analysis grain geometry demonstrated arrangements produce significant differences grain entrainment shear stress however analysis neglected potential interactions sediment patches local hydraulics grain entrainment present series flume experiments measure influence sediment patches grain entrainment flume planar bed roughness much smaller diameters mobile grains experiment sediment added either individual grains single sediment pulse flow increased sediment entrained analysis experiments demonstrates individual grains coarse grains entrained higher discharge fine grains sediment patches present different entrainment discharge coarse fine grains greatly reduced sheltering effect patches also increases entrainment discharge isolated grains entire sediment patches break eroded quickly rather progressive grain grain erosion discharge increases tendency patches become elongate flow aligned randomly distributed across bed one implication research critical shear stress bedrock alluvial channels function extent sediment cover another influence sediment patches equalizes critical shear stresses different grain sizes grain locations meaning factors may need accounted research needed quantify interactions sediment patches grain entrainment local hydraulics rougher bedrock surfaces different types sediment supply copyright john wiley sons ltd
cross sectional population based study aimed evaluate relationships muscle mass body fat phenotypes risk cardiovascular disease cvd events eligibility lipid management participants korean adults men women aged free stroke coronary heart disease provided complete data estimating cvd risk body composition fifth korea national health nutrition examination survey four levels combined muscle mass body fat determined using sex specific quintiles appendicular skeletal muscle mass divided height squared sex specific quintiles total body fat percentage ten year cvd risk calculated using pooled cohort equations framingham risk scores lipid lowering medication eligibility determined using american college cardiology american heart association acc aha adult treatment panel atp iii guidelines compared reference group risk cvd events higher men low muscle mass high body fat factors combined cvd risk lower women low muscle mass higher women high body fat nonsignificant women factors participants low muscle mass high body fat higher odds medication eligibility using acc aha guidelines atp iii guidelines higher estimated cvd risk associated combined phenotypes low muscle mass high fat men women also relationship phenotypes lipid lowering medication eligibility guideline specific
introductionthe janus kinase jak gain function mutation hallmark bcr abl negative myeloproliferative neoplasms mpns study analyzed jak mutations patients tested methodsexons jak sequenced samples patients harboring mutations clinically evaluated resultsof patients jak mutations female male local referred additional genetic abnormalities median patient age years one pediatric patient agreement previous reports patients positive jak mutation non jak mutations detected remaining nine patients five mutation one ddel silent edelinsk ndelinsm mutations diagnosis house cases revealed predominance mpn patients cases conclusionjak prevalent mutation detected among patients study non jak mutations identified exons corresponding recently reported mutations except novel ndelinsm
consider problem solving large sparse linear systems coefficient matrix possibly singular equations consistent block two stage methods inner iterations performed using alternating methods studied methods ideal parallel processing provide general setting study parallel block methods including overlapping convergence properties methods established matrix question either matrix symmetric matrix different parallel versions methods implementation strategies without overlapping blocks explored reported experiments show behavior effectiveness designed parallel algorithms exploiting benefits shared memory inside nodes current smp supercomputers civil comp ltd elsevier ltd rights reserved
experimental field evidence indicate positive link social preferences age strikingly elderly young adults however possible seemingly positive link age preferences stems confounds experimental procedure dictator game study find elderly participants indeed transfer higher shares endowments peers standard sample student participants result holds good even treatments accounting wealth differences experimenter demand effects however observe difference behavior compare elderly participants students previously participated economic experiments accordingly possible seemingly stronger social preferences elderly due confounds associated lack experience economic experiments addition comparing incentivized hypothetical transfer decisions observe hypothetical bias treatments take framing treatments standard give framing elsevier rights reserved
introduction biological disease modifying anti rheumatic drugs bdmards often administered combination methotrexate target specific inflammatory mediators transformed treatment rheumatic diseases especially rheumatoid arthritis also spondyloarthritides however high cost drugs many countries restricts patient access many bdmards reached near patent expiration numerous biosimilar drugs development already approved biosimilars generally priced lower reference products rps bio originators prices come hoped patient access drugs increase making safety drugs area major interest areas covered article reviews publicly available safety data biosimilars expert opinion available data biosimilars relate tumor necrosis factor inhibitors tnfi rituximab anti monoclonal antibody biosimilar use around world increases evidence supporting clinical safety biosimilars compared rps also grows date new safety concerns raised studies tnfi rituximab biosimilars treatment safety profiles consistent rps however careful post marketing pharmacovigilance remains necessary
major function lying furniture meet needs one rest sleep fully regenerate body energy correct positioning obtained structural types furniture comply anthropometric measures user physical mechanical properties interaction man bed paper describes results research bed ergonomics function healthy sleep presented ale latest requirements considering relation bed anthropometric requirements use results show shape dimensions lying furniture determined structural shapes materials factors building standards flats furniture types frame structure etc
result integration different methodological tools life cycle assessment dynamics simulation studies evaluate economic cost potential environmental impact alternative water supplies rainwater greywater urban use software program plugrisost pluvials greys sustainability developed modelling tool aims contribute urban water planning smart city development plugrisost simulation model facilitates evaluation rainwater harvesting rwh greywater systems different scales urban planning tool known thus far integrate structural elements sizing storage tanks estimated cost quantitative environmental analysis plugrisost adequate tool design stage provides environmental economic information related rainwater tank sizing estimates conservative tools plugrisost contributes design urban infrastructure low environmental impact infrastructure incorporates use rainwater self sufficiency analysis water cities using plugrisost found singlehouse scale economic viability rwh system would possible price water greater euros environmental analysis would favourable tanks less storage capacity apartment building scale results euros respectively elsevier ltd rights reserved
ambient intelligence concept provides vision society future people find environment intelligent intuitively usable interfaces manuscript applies definition specific environment higher education context czech republic existence called generation characteristics included individuals represent main rationale paper particular sections paper three visions focus intelligent assistance graduation thesis preparation smart lecture halls smart university campuses described related architectures depicted furthermore results survey evaluating three main aspects feasibility willingness use accessibility technologies visions presented
context psychosocial factors impact lung transplant outcomes however currently unknown whether abuse survivorship influences lung transplant survival objective characterize abuse history adult lung transplant patients determine whether history associated mortality patients participants adult lung transplant recipients evaluated main outcome measures main outcome post lung transplantation survival secondary outcomes included demographic transplantation psychological assessment differences history abuse survivorship without results thirty three lung transplant recipients male median age years included history abuse survivorship common associated decreased survival following lung transplantation difference sex marital status smoking history abuse survivors denied victim abuse abuse survivors higher personality assessment screener total score measure maladaptive personality traits conclusion abuse survivorship common lung transplant patients associated increased posttransplant mortality increased maladaptive personality traits preliminary evidence suggests lung transplant patients screened abuse history provided appropriate treatment survivorship issues potentially improve health outcomes transplantation
purpose investigated efficiency simplified comorbidity score scs predicting postoperative complications prognosis elderly patients undergoing video assisted thoracoscopic surgery vats lung cancer methods reviewed patients aged years older underwent pulmonary resection vats lung cancer january december scs assigns different scores patients comorbidities namely smoking diabetes mellitus renal insufficiency respiratory neoplastic cardiovascular comorbidities alcoholism patients divided high scs group scs low scs group comparative analysis differences perioperative factors prognoses results limited resection frequent high scs group low scs group postoperative complications frequent high scs group low scs group logistic regression analysis revealed high scs significantly predictive postoperative complications odds ratio year overall survival rate low scs group high scs group conclusions scs predict likelihood postoperative complications prognosis elderly patients vats treated lung cancers
performance energy consumption fundamental design implement embedded flight controllers unmanned aerial vehicles important challenge faced designers find balance performance small size energy consumption navigation system moreover airship flights unknown environments conventional predefined routes useless intelligent line route planning systems required work evaluates performance energy consumption real time line route planner based particle swarm optimization evaluation carried performance restricted computation systems particular use bit microcontroller systems widely used automatic control small unmanned aerial vehicles results show implementation pso algorithm line route planning bit microcontroller feasible execution times per pso iteration seconds moreover energy consumption vary joules per pso iteration pso iteration comprises whole data processing find next advance point unknown region consider results quite promising sense show feasibility implementing complex optimization algorithm performance restricted computer systems
due cytochrome cypa metabolism clinical trials ibrutinib treated chronic lymphocytic leukemia cll patients prohibited concurrent medications metabolized cypa evaluated concomitant medication use ibrutinib treated cll patients outside context clinical trials seventy five patients medications could increase ibrutinib toxicity drugs could decrease ibrutinib efficacy nineteen patients concomitant cypa inhibitors moderate strong cypa inducers two patients cypa inhibitors inducers although ibrutinib starting dose changed patients cypa interacting medications difference month progression free survival rate ibrutinib discontinuation observed patients routine clinical practice cll patients commencing ibrutinib concomitant medication potential influence ibrutinib metabolism formal medication review pharmacist considered patients initiating ibrutinib
mitochondria important regulators cell death cell survival mitochondrial levels critically involved processes one hand excessive mitochondrial leads induced mitochondrial outer membrane permeabilization thus apoptosis hand mitochondria need order efficiently fuel tricarboxylic acid cycle maintain adequate mitochondrial bioenergetics obtaining mitochondria largely dependent close contact sites endoplasmic reticulum called mitochondria associated membranes inositol trisphosphate receptors responsible release comes surprise release subsequent uptake mitochondria finely regulated cancer cells often modulate transfer mitochondria order promote cell survival inhibit cell death important regulators signals onset cancer cell lymphoma bcl family proteins increasing number reports highlight ability bcl protein family members finely regulate transfer mitochondria healthy cells cancer review focus recent insights dynamic regulation mitochondrial fluxes bcl family members impacts cell survival cell death mitochondrial energy production
consequence position functions iter blanket system subjected significant heat loads nominal reference conditions therefore design cooling system particularly demanding coolant water distributed individually blanket modules bms manifold piping makes highly parallelized system mass flow rate distribution finely tuned meet operation constraints adequate margin burn plasma facing components even distribution water flow among called plasma facing fingers blanket first wall panels high enough water flow rate avoid excessive water temperature outlet pipes maximum allowable water velocity lower manifold pipes furthermore overall pressure drop flow rate shall within fixed specified design limit avoid unduly unbalance cooling among modules analyses carried following computational fluid dynamic cfd approach based finite volume method adopting cfd commercial code assess thermal hydraulic behaviour single circuit iter blanket cooling system paper describes code benchmarking needed determine best method get reliable timely results since experimental tests available iter organization full scale prototypes shield blocks cfd analyses performed investigate fluid dynamic behaviour steady state conditions compare numerical experimental results results obtained presented critically discussed elsevier rights reserved
using method adjoint equations described ref calculated maximum thermal efficiencies theoretically attainable free piston stirling carnot engine generators considering work loss due friction joule heat net work done carnot cycle negative even duration heat addition optimized give maximum amount heat addition situation brayton cycle described previous paper stirling cycle net work done positive thermal efficiency greater otto cycle described previous paper factor compression ratios stirling cycle much better otto brayton carnot cycles found optimized piston trajectories isothermal isobaric adiabatic processes compression ratio maximum volume working fluid three processes facilitated present analysis optimized piston trajectories carnot stirling cycles brayton otto cycles respectively
corona layer macromolecules formed nanoparticle surface vivo substantially change biological identity nanomaterials possibly trigger adverse responses body tissues dissecting role corona development particular disease may provide profound insights understanding toxicity nanomaterials general present study explored capability different silica nanoparticles sinps induce silicosis mouse lung analyzed composition coronas formed particles found sinps certain size surface chemistry could specifically recruit transforming growth factor beta tgf beta intotheircorona subsequently induces development lung fibrosis embedded corona sinps tgf beta remarkably stable free form fibrosis triggering activity significantly prolonged study meaningfully demonstrates specific corona component certain nanoparticle could initiate particular pathogenic process clinically relevant disease model findings may shed light understanding molecular mechanisms human health risks correlated exposure small scale substances
four novel polymers poly decyl carbazole alt benzene pbcz poly decyl carbazole alt bis phenyl phenyl phosphine oxide ptppocz poly decyl carbazole alt phenyl diphenyl phosphine oxide ptppocz poly decyl carbazole alt bis phenyl phenyl phosphine oxide pttpocz synthesized thermal photophysical properties device applications investigated correlate chemical structures photoelectric performance bipolar host materials phosphorescent organic light emitting diodes show high thermal stability revealed high glass transition temperatures thermal decomposition temperatures weight loss polymers wide band gaps relatively high triplet energy levels result spin coating method used prepare green phosphorescent organic light emitting diodes polymers ptppocz ptppocz pttpocz typical host materials green device polymer ptppocz host material shows electroluminescent performance maximum current efficiency center dot maximum external quantum efficiency maximum brightness center dot reduced efficiency roll center dot much better devices hosted polymers pttpocz ptppocz
dynamic model wind flow wind farms developed paper model based spatial discretization linearized navier stokes equation combined vortex cylinder theory spatial discretization model performed using finite difference method provides state space form dynamic wind farm model model provides approximation behavior flow wind farm obtains wind speed vicinity wind turbine afterwards model validated using measurement data energy research center netherlands wind turbine test site wieringermeer netherlands employing outcomes two wind flow models end goal work present wind farm flow model ordinary differential equations applied wind farm control algorithms along load power optimizations copyright john wiley sons ltd
paper describes experience introducing remote laboratories universidad del bio bio ubb remote laboratories common resource practical activities employed universities method offers flexible time access best utilize available laboratory equipment laboratory experiences allow identify control physical devices remotely universities possess expensive equipment may shared people remote access system aim contribution thereby apply experience remote laboratories ubb mainly automation engineer experiments carried demonstrate effectiveness using remote laboratories coupled tanks system feedback instruments company considering remote access coupled tanks system sistema laboratorios distancia sld used
introduction hospitals begun shift toward patient centered care pay performance system established patient protection affordable care act pediatrics needs caregiver pediatric patient taken account pediatric practices shifting toward family centered approach although primary drivers well defined identifying key patient experiences lead higher patient satisfaction would enable meaningful clinical encounter better understand patient experience examined waiting time elements physician patient interaction pediatric neurology predict determining factor patient satisfaction physician patient interaction methods material patient satisfaction surveys sent families via mail mail ambulatory pediatric neurology visit visits took place january december one multiple locations children health system spanning four states likert scale used surveys top box method measuring percent survey questions rated used filter data database statistical analysis using pearson correlation used data analysis likelihood recommend practice dependent variable results five survey questions correlated overall likelihood recommend practice cheerfulness practice staff working together cleanliness practice wait time clinic entering leaving likelihood recommending care provider conclusion pediatric neurologists striving enhance overall patient satisfaction practices work toward providing atmosphere supports office staff cheerfulness teamwork visit efficiency provided clean friendly environment
affine equivalence classification boolean functions significant applications logic synthesis cryptography previous studies classification limited large set boolean functions complex operations affine group although many research affine equivalence classification parts boolean functions recent years results entire set boolean functions best existing result achieved harrison affine equivalence classes variable boolean functions paper presents concise formula affine equivalence classification entire set boolean functions well formula affine classification boolean functions distinct set size respectively method outlined paper greatly simplifies affine group action constructing isomorphism mapping affine group permutation group method compute affine equivalence classes variables experiment results indicate scheme calculating affine equivalence classes variables significant advancement previous published methods
smartphone apps developed complement smoking cessation treatment current study aimed analyze content available apps portuguese two operational systems android ios fifty one apps found itunes google play content evaluation included apps focused smoking cessation total apps ios android app categorized according approach smoking cessation scored according level adherence treating tobacco use dependence smoking cessation treatment guideline nine apps classified calendars information tools calculators cigarette trackers hypnosis apps showed low level adherence guideline mean score recommend available apps revised future apps developed using evidence based practices smoking cessation
article devoted development method diagnosing psychopathy antisocial dissocial personality disorder modern researchers mostly use methods experiment expert assessment clinical interview different combinations personality disorders including psychopathy however nowadays growing need development psychopathy diagnosis method would less labour intensive less expensive objective one recently developed models psychopathy trierarchic conceptualization patrick offers new way operationalize diagnose psychopathy authors tested method russian population including common sample well criminal offender sample consisting individuals suspected accused convicted violent crimes subject current research psychopathic traits measured tested method carried statistical content analyzes data study allowed conclude tested russian version triarchic psychopathy measure effective enough used research purposes however research required order render measure valid practical use
analytical treatment linear elastic isotropic material full space reinforced interfacial thin film axisymmetric normal loading addressed thin film modeled extensible membrane perfectly bonded half spaces virtue love potential function hankel integral transform elastic fields system explicitly written form semi infinite line integrals analytical results verified special cases corresponding surface stiffened half space classical material problem limiting cases reinforced homogeneous full space inextensible membrane presented discussed proposed formulation also applicable studying reinforced auxetic materials negative poisson ratio surface interface effect elastic responses two perfectly bonded half spaces also simulated assigning equivalent surface elastic constant membrane stiffness effects thin film stiffness material properties loading depth surface interface effect studied numerical examples elsevier ltd rights reserved
show longest common prefix lcp array generated product suffix array construction algorithm saca nong algorithm builds fischer proposal fischer wads also runs linear time uses constant extra memory constant alphabets elsevier rights reserved
drawing one year long ethnographic study paper deals parenting strategies polish migrants belfast northern ireland first provides general overview context migration northern ireland introduces theoretical framework study drawing scholarly debates acculturation indicating gaps scholarship polish migration following upbringing strategies polish parents examined particular focus questions transnationalism assimilation next dynamic processual nature strategies emphasized methods used paper depth interviews participant observation
background number program level counselor level factors known impact adoption treatment innovations program leadership considered primary factor importance leadership among clinical staff innovation transfer less known objectives included explore influence two leadership roles program director individual counselor recent training activity relationship counselor attributes training endorsement methods sample included clinical staff treatment programs structural equation model evaluated key hypothesized relationships exogenous endogenous variables related two leadership roles results importance organizational leadership climate counselor attributes particularly counseling innovation interest influence recent training activity supported subset counselors attended developer led training new intervention found training endorsement higher among high innovation interest influence conclusions findings suggest leadership level impacts organization different ways yet promote impede technology transfer
interpersonal youth violence growing public health concern united states high sense school connectedness found protective factor youth violence high school course aims enhance school connectedness developed evaluated investigate students sense school connectedness association violent attitudes behaviors survey data students predominately asian pacific islander student body analyzed assess level school connectedness violent attitudes behaviors analysis variance used identify differences school connectedness violence scores related students demographic characteristics role school connectedness relationship student demographic characteristics violent attitudes behaviors examined structural equation modeling overall students reported moderately high sense school connectedness school connectedness found negatively associated violent attitudes self reported violent behaviors multiple group analyses conducted across ethnic groups found differential associations school connectedness violence variables results highlight value disaggregating asian pacific islander category need future research contextualize clarify relationship school connectedness interpersonal youth violence help inform development evidence based strategies prevention programming focus school connectedness address disparities interpersonal youth violence outcomes
nature consciousness autonomy individual smind focus interest throughout past century inspired many theories models revival studies psychological trauma dissociation remained outside mainstream psychiatry psychology psychoanalysis part past century provided new opportunity revisit intellectual scientific endeavor paper attempts integrate series empirical theoretical studies psychological consequences developmental traumatization may yield insight factors threaten integrity human consciousness paper proposes individual experience distorted reality betrayal precipitates cyclical dynamic individual external world disrupting developmental function mutuality essential maintenance integrity internal world inner world turn regulated vis vis external reality dissociation common factor types post traumatic syndromes facilitated violation boundaries relational omission intrusion represented distinct effects consequences childhood neglect abuse recent research conducted clinical non clinical populations shows bimodal undermodulation overmodulation bipolar intrusion avoidance neurobiological phenomenological characteristics post traumatic response seem reflect parallel distinct structures control separate networks covering sensori motor cognitive emotional systems understanding provides conceptual framework assist explanation diverse post traumaticmental trajectories culminate common final pathway comprised partly overlapping clinical syndromes complex ptsd dissociative depression dissociative identity disorder borderline phenomena crucial theoretical clinical importance thesemaladaptive post traumatic psychological formations regarded processes right rather personality disorder innate individual mental division may perform internal detachment serve preserve genuine aspects subject time reclaimed via psychotherapy paper attempts integrate ideas reference previously proposed theory functional dissociation self sar ozturk
background cryptosporidium spp important intestinal protozoan causing diarrhea humans livestock wild animals cryptosporidium infection remains major public health issue epidemiology humans still unclear particularly rural china study designed determine prevalence risk factors associated cryptosporidium infection rural southwestern chinese community methods community based cross sectional survey conducted among residents small town autonomous prefecture southwest china blood samples examined using broad set quality controlled diagnostic methods hepatitis virus hbv human immunodeficiency virus hiv stool specimens processed using modified acid fast staining method microscopically examined cryptosporidium infection univariable multivariable analyses performed determine risk factors associated cryptosporidium infection results majority participants people poor living conditions unsatisfactory hygiene habits study area low socioeconomic status individuals included analysis hiv positive infected hbv cryptosporidium infection prevalences hiv hbv hiv cryptosporidium hbv cryptosporidium infections respectively prevalence hbv infection higher individuals cryptosporidium infection chi owning livestock poultry important risk factor cryptosporidium infection aor cryptosporidium infection significantly associated hbv infection aor hiv infection aor conclusions prevalence cryptosporidium infection high rural area southwestern china investigated significant association hbv infection cryptosporidium infection investigations needed determine significance cryptosporidium infection patients infected hbv
porcine circovirus type pcv recently reported elicit unfolded protein response upr via activation perk eif alpha rna activated protein kinase like endoplasmic reticulum kinase eukaryotic initiation factor alpha pathway study attempted examine viral protein might involved inducing upr whether cellular event would lead apoptosis cells expressing viral protein transient expression found replicase rep capsid cap proteins pcv could induce stress shown increased phosphorylation perk subsequent activation eif alpha atf activating transcription factor chop ccaat enhancer binding protein homologous protein axis cap expression rep significantly reduced antiapoptotic cell lymphoma bcl increased caspase cleavage possibly due increased expression chop since knockdown perk rna interference clearly reduced cap induced chop expression caspase cleavage apoptotic cell death possibly partially rescuing bcl expression propose connection cap induced upr apoptosis via perk eif alpha atf chop bcl pathway study together earlier studies provides insight mechanisms underlying pcv pathogenesis
bilateral filter edge preserving smoother diverse applications image processing computer vision computer graphics computational photography filter uses spatial kernel along range kernel perform edge preserving smoothing paper consider gaussian bilateral filter kernels gaussian direct implementation gaussian bilateral filter requires sigma operations per pixel sigma standard deviation spatial gaussian fact well known direct implementation slow practice present approximation gaussian bilateral filter whereby cut number operations per pixel arbitrary sigma yet achieve high quality filtering almost indistinguishable output original filter demonstrate proposed approximation orders faster practice compared direct implementation also demonstrate approximation competitive existing fast algorithms terms speed accuracy
international organizations ranging large mncs small born global firms increasingly recognizing multicultural employees help operate across countries across cultures however multiculturals individuals identify internalize one culture diverse group organizations seeking leverage potential benefit deeper understanding resources possess challenges face conducted three studies total participants test relationships multicultural identity patterns personal social task outcomes consistent results across studies indicated individuals cultural identities higher identity plurality social capital higher levels intercultural skills fewer cultural identities individuals integrated cultural identities higher identity integration experienced higher levels personal well separated based results advocate two directions future research multicultural employees moving beyond cognitive mechanisms alone examining monocultural multicultural individuals simultaneously along spectrum identity plurality
aims background describe case woman cured osteosarcoma took part mono institutional study using different questionnaires assess pediatric cancer survivors quality life behavioral features years completing cancer treatment results high levels psychological distress psychopathologic symptoms revealed patient prompted offer specific prolonged support institution since refused seek help psychiatric services woman revealed dysfunctional social family setting borderline personality disorder hospitalized attempting suicide psychological distress previously come light long follow cancer conclusions cancer survivors risk psychological behavioral problems followed time questionnaires standard scales important enough physician patient relationship crucial bring patient psychological issues needs means dedicated resources made available whenever possible
background multiple sclerosis inflammatory neurodegenerative disorder central nervous system cns reliable biomarkers urgently needed diagnosis management clues pathogenesis ebv implicated objective measure igg antibodies ebv nuclear antigen ebna innate inflammation status paired serum cerebrospinal fluid csf samples untreated relapsing remitting rrms patients materials methods anti ebna igg titers beta tnf alpha cytokine levels measured untreated rrms patients healthy controls results found higher serum anti ebna igg levels rrms patients healthy controls interestingly levels relative total protein much higher csf whereas anti ebna antibodies significantly higher sera detailed analysis showed anti ebna antibodies relative total igg also higher serum majority rrms patients compared csf levels anti ebna igg showed strong correlation serum csf conclusion findings newly diagnosed rrms patients imply anti ebna antibody production mainly periphery innate immune responses preferentially cns potential disease biomarkers implications pathogenesis warrant investigation published elsevier
undeclared allergens chocolate products responsible numerous allergen related recalls united states survey conducted determine prevalence undeclared milk peanut dark chocolate bars respectively concentrations milk nonfat dry milk peanut three samples chocolate product determined two milk peanut specific enzyme linked immunosorbent assay kits chocolate bar products milk advisory statement milk concentrations limit quantitation ppm majority concentrations ppm additional chocolate bars traces milk statement contained ppm milk fifteen percent chocolates labeled dairy free lactose free labeled vegan positive milk concentrations ppm even chocolates reference milk label products contained ppm milk survey chocolate products peanuts revealed products advisory statement contained peanut highest concentration ppm nine chocolates bearing peanut free allergen free statement negative peanut chocolates label statement peanut positive peanut concentrations ppm evaluation multiple lots four chocolate products revealed milk consistently present absent products investigated mixed results obtained multiple lots tested peanut study indicates large proportion dark chocolate bars contain undeclared milk type advisory statement absence milk advisory statement products predict amount absence milk protein contrast lower proportion chocolates containing undeclared peanut found consumers food allergies cautious purchasing dark chocolate products particularly advisory label statement
land surface temperature important parameter land surface atmosphere studies set synchronously observed ground truth temperature training data required empirical semiempirical statistical neural network methods retrieving passive microwave pmw remote sensing data provide information choice suitable dataset retrieval pmwremote sensing spatiotemporal comparison moderate resolution imaging spectroradiometer modis meteorologically observed situ themeteorologically observed near surface air temperature situ european center medium range weather forecast reanalysis products era interim era south china season daytime nighttime conducted paper results show large discrepancy modis situ exists whereas discrepancies modis situ era relatively smaller daytime nighttime period differences dataset relatively much smaller modis representative satellite pixel scale smaller spatial scale mismatch pmw data compared situ meteorological observation modis suitable daytime nighttime pmw model calibration synchronously observed almost clear sky condition contrast pmw model calibration within daytime period synchronously obtained situ suitable used training data ground temperature daytime period derived pmw required modis unavailable situ selected ground truth model calibration however noticed inversion results near surface air temperature rather remarkably reanalysis products era presents alternative choice daytime nighttime model calibration modis products situ temperature available comparison example pmw retrieval nighttime period given showing promising performance deriving applicable pmw inversion model based selection appropriate training dataset
order improve economical environmental performances diesel engines present paper aims bring forefront solutions increase efficiency supercharging process carried aggregates comprex type pressure waves one solution drive comprex supercharged engine currently happens motor speed electric motor modified means electronic management system depending speed load diesel engine paper presents experimental results obtained investigation supercharged diesel engine comprex driven type according proposed solution
aims objectives describe tracheostomised patients intensive care experience acts communication better understand experiences context transitions theory background waking intensive care unit unable speak mechanical ventilation challenging communication aids available patients still report difficulties communicating investigating mechanically ventilated patients experience communication context transitions theory might elucidate new ways supporting transitions ventilated design qualitative descriptive design methods eleven patients previously tracheostomised intensive care unit included quality improvement project conducted university hospital norway participants tracheostomised days semistructured interviews conducted june august months hospital discharge transcripts analysed using inductive content analysis results participants reported great diversity emotions experiences attempting communicate tracheostomised one overarching theme emerging analysis experience caring understanding despite uncomfortable feelings due troublesome communication theme consists three categories category emotionally challenging shows patients struggled initially time coping improved revealed category experience changes time despite difficulties participants described positive experiences shown category successful communication conclusion importance patients experiencing caring understanding despite difficult situation constitutes core finding findings suggest participants went different transitions reached end transition experiencing increased stability relevance clinical practice despite challenges communication participants reported caring safety provided health care professionals significant experiences viewed nonverbal communication important
proponents opponents claim mental disorders natural kinds compare mental disorders paradigmatic examples natural kinds inquire set properties achieve three scientific tasks explanation prediction intervention argue comparative strategy fails take intervention related properties mental disorders replace call trilateral strategy strategy guided first person accounts individuals mental disorders relevant clinical scientific work psychopathology illustrate trilateral strategy works focus schizophrenia example used sides debate
individuals seasonal affective disorder sad may decreased retinal sensitivity non image forming light input pathway examined post illumination pupil response pipr among individuals sad healthy controls identify possible differences melanopsin signaling pathway also investigated whether melanopsin gene opn variations would predict variability pipr fifteen sad control participants women mean age years assessed fall winter participants diagnosed based dsm criteria infrared pupillometry used measure pupil diameter prior red blue stimuli response blue light sad group reduced pipr lower pipr percent change relative controls pipr blue stimulus also varied basis opn genotype opn genotype findings may indicate individuals sad less sensitive light input pathway measured pipr leading differences neurobiological behavioral responses alertness circadian photoentrainment melatonin release addition sensitivity may vary based sequence variations opn although larger sample replication needed elsevier ireland ltd rights reserved
time rupture thick high density polyethylene geomembrane aged typical landfill composite liner configuration investigated pressure kpa degrees geomembrane underlain geosynthetic clay liner needle pinched nonwoven geotextile protection layer separating drainage gravel containing leachate seventeen diameter tests conducted addition months required deplete antioxidants stage tests indicated lag period stage months time start degradation rupture stage iii months giving total inferred time rupture months years brittle ruptures per sample million cracks per hectare ruptures predominately oriented machine direction located directly beneath gravel contact side gravel indentation gravel indentations ruptures gravel indentations least frequent largest calculated strains perpendicular rupture direction rupture occurred although average stress crack resistance ruptured geomembrane samples still approximately minimum results indicate importance minimizing tensile strains geomembrane design liner system american society civil engineers
nonlinear acoustic echo cancellation present algorithm estimate threshold clipping effect room impulse response vector suppressing time varying cost function common way suppress time varying cost function pair parameters alternatingly minimize function respect parameter keeping fixed refer adaptive alternating minimization however since cost function threshold nonconvex conventional methods approximate exact minimizations gradient descent updates causes serious degradation estimation accuracy occasions paper exploring fact cost function threshold becomes piecewise quadratic propose exactly minimize cost function threshold closed form suppressing cost function impulse response vector online manner call exact online adaptive alternating minimization proposed method expected approximate efficiently adaptive alternating minimization strategy conventional methods numerical experiments demonstrate efficacy proposed method
aim study investigate efficacy pre emptive early delayed pulsed electromagnetic field pemf treatment cartilage subchondral trabecular bone knee osteoarthritis rats induced low dose monosodium iodoacetate mia seventy five week old male sprague dawley rats assigned five groups pre emptive pemf early pemf delayed pemf control osteoarthritis induced injecting mia rat right knee joint control rats received single sterile saline injection right knee male rats received pre emptive day end week early end week end week delayed end week end week pemf treatment weeks rats sacrificed time point right knees harvested sacrifice micro computed tomography histology biomarker analyses performed found pre emptive pemf treatment preserved subchondral trabecular bone microarchitecture prevented subchondral bone loss mia induced rat model early delayed pemf treatment maintained subchondral trabeculae pemf treatment increased bone cartilage formation decreased bone cartilage resorption pre emptive early pemf treatment moderate effects cartilage degradation time point treatment initiation crucial treating pemf might become potential biophysical treatment modality osteoarthritis wiley periodicals inc
many technological developments contribute progress education system especially engineering education affected latest developments internet technology therefore engineering education system keep developing technology using web based systems work provides convenient method improve students learning outcomes skills real time experiences multidisciplinary engineering education electrical electronics mechatronics control engineering study web based real time laboratory system developed using programmable logic controller connected matlab server via object linking embedding process control developed educational tool accessed internet currently registered students remote accessible real time mechatronic system consists programmable logic controller connected matlab server water level tank servo pneumatic actuator pressure transmitter two real time cameras established system provides real time experience students using real instruments accessible internet developed educational tool used complementary practice engineering courses sensors actuators control systems industrial automation systems
article presents examination mark twain feminist least man considering gender roles awful terrible medieval romance hoax story discusses gender roles well touching women treatment men sexuality bisexuality homosexuality obviously cross dressing work touches relationship appears incestuous author delves areas undefined designated grammatical term gender deliberately complicated plot convey dilemma facing women male dominated society clemens exposes hypocrisy unfairness women confront absurdity behind confusion sexual roles story underscore bizarre situation assumed unacknowledged male attitudes created maintained men expect women accept incompleteness deliberate nonending medieval romance symbolize woman unfinished unfulfilling situation continuing status resolution sight
surface bughole concrete one surface imperfections concrete appearance detection evaluation surface bugholes always difficult problem paper established method detect surface bugholes concrete image analysis put forward evaluation parameters surface bugholes shooting distance affect shooting area detection accuracy image method partition shooting must used ensure detection accuracy according size concrete member based image processing toolbox matlab image gray contrast enhancement otsu image threshold segmentation technology used extract characteristics bugholes concrete surface threshold value shape characteristic coefficient distinguish cracks surface bugholes chosen relationship cib scale area ratio bughole established parameters area ratio maximum diameter bugholes comprehensively evaluate surface quality concrete elsevier ltd rights reserved
significant amount existing research dealt negative effects music people behavior studies shown music prosocial lyrics increase prosocial behavior study focuses positive effects music prosocial lyrics people everyday setting based general learning model field experiment female conducted test whether people exposed music prosocial lyrics engaged prosocial behavior buying fair trade products compared regular products exposed songs neutral lyrics guests cafe randomly assigned either prosocial neutral music condition monitored two observers instructed report prosocial purchase fair trade coffee tipping behavior guests results indicated significant positive association prosocial behavior prosocial lyrics songs played study shows likely music prosocial lyrics influence one prosocial purchase behavior everyday situation underlying mechanisms still poorly researched findings support theoretical assumptions
self seen surprising resurgence recent anthropological theorizing revitalizing interest whether studied ethnographically issues brought fore newly popular psychotherapy technique internal family systems therapy ifs practiced eating disorders clinic clinicians clients negotiate tensions model understanding multiple refracted self managed care companies insistence personal responsibility considering moral pragmatic work ifs clinic new critical anthropology selfhood illuminates vectors economic political commitments become imbricated self ways resist psychologism subjectivism holding productivealbeit sometimes troublingtension
backgroundpolymorphisms receptor advanced glycation end products rage gene studied various autoimmune disorders hashimoto thyroiditis also increased oxidative stress described patients hashimoto thyroiditis aim study investigate possible role two common rage polymorphisms hashimoto thyroiditis parallel studied oxidative stress levels materials methodsa total consecutive euthyroid women examined classified three groups hashimoto thyroiditis treatment hashimoto thyroiditis without treatment controls rough evaluation oxidative stress total lipid peroxide levels serum measured alui mfei polymorphisms rage studied genomic dna resultssignificant association rage system hashimoto thyroiditis found regard prevalence polymorphism levels oxidative stress significantly elevated hashimoto thyroiditis patients treatment analysis demonstrated oxidative stress cut value mol associated increased risk progression hashimoto thyroiditis euthyroidism hypothyroidism risk increased carriers rage polymorphism conclusionsour findings indicate examined risk factors may implicated occurrence hashimoto thyroiditis covers fraction pathophysiology disease
present review examines macromolecular structure functional groups pectin affect functionality particular focus interfacial activity venture description particularly complex pectin structure describe major building blocks properties following section role structural parameter discussed particular attention protein degree acetylation methylation molecular weight branching finally discuss modification extraction conditions could tailored obtain pectin desired emulsification properties proposed pectin protein content range degree acetylation greater molecular weight mol enriched segments likely perform well emulsifier tailor structure aqueous extraction protocol low values strong monoprotic acid hcl one step solvent precipitation selected proposed set extraction conditions could used first step towards rational design pectin desirable interfacial functionality elsevier ltd rights reserved
psoriasis complex inflammatory disorder skin affects people united states associated psoriatic arthritis potentially debilitating inflammatory joint condition psoriatic patients also increased risk lymphoma heart disease type diabetes obesity metabolic syndrome degree patient affected psoriasis vary greatly treatment available patients includes topical products phototherapy traditional systemic medications biologics high cost healthcare united states healthcare providers must consider direct indirect costs psoriasis annual cost psoriasis united states year approximately billion current guidelines utilize evidence based practice recommendations help provide patients cost effective treatment yield best results
green eco friendly technology triboelectric nano generator teng harvest energy human motion generate electricity tengs widely applied wearable electronic devices replace traditional batteries however surface tengs easily contaminated breeds bacteria threat human health report antibacterial composite film based triboelectric nanogenerator acf teng uses exchanged zeolite zeolite polypropylene composite film triboelectric layer adding small amount zeolite excellent antibacterial properties increase dielectric permittivity improve surface charge density composite films enhances output performance acf teng open circuit voltage shortcircuit current transferred charge acf teng pure film based teng respectively silver zeolite acf teng effectively kill escherichia coli fungi used insoles acf teng resist athlete foot fungus effectively work power source light light emitting diodes charge capacitors acf teng wide application prospects self powered medical healthcare electronics
endocrine disruption aquatic wildlife increasingly reported changes gene aromatase expression used indicators however natural fluctuations brain gonadal aromatase expression physiological indexes previously measured fish species jenynsia multidentata throughout complete reproductive cycle biological effects anthropogenic inputs responses accordingly males monthly collected year reference contaminated site physicochemical analyses water samples done reflected strong anthropogenic impact brain aromatase fluctuates along reproductive cycle species noticeably increase brain gene expression begins month delay contaminated site mismatch also evidenced testes weight hepatosomatic index also revealed adverse effects polluted site turn alterations observed biological responses could affecting reproduction fish species
objective systematic review presents loading protocols applied using implants screws orthodontic treatments materials methods clinical trials assessed use implants screws orthodontic anchorage studies involving treatment syndromic patients surgery simultaneous treatments appliances mini plates considered electronic databases medline medline process non indexed citations lilacs pubmed embase web science evidence based medicine reviews searched help senior health sciences librarian abstracts appeared fulfill selection criteria selected consensus original articles retrieved evaluated methodological checklist references also hand searched possible missing articles results eleven articles fulfilled selection criteria established five studies involved use implants six involved use screws orthodontic purposes individual methodological analysis article made conclusions loading protocols implants involve minimum waiting period months applying orthodontic forces loading protocols screws involve immediate loading waiting period weeks apply forces success rates implants average higher screws
lsst camera video processing channels readout large focal plane requires compact readout chain correlated double sampling technique generally used signal readout ccds also adopted application implemented called dual slope integrator method designed implemented asic lsst analog signal processing asic aspic goal amplify signal close output order maximize signal noise ratio send differential outputs digitization others requirements chip process output half ccd channels operate specific back end board designed especially lab test purposes manages clock signals digitizes analog differentials outputs aspic stores data memory contains adcs bits kwords memory usb interface fpga manages signals components board generates timing sequence aspic firmware written verilog vhdl languages internals registers permit define various tests parameters aspic labview gui allows load update registers check proper operation several series tests including linearity noise crosstalk performed past year characterize aspic room cold temperature present aspic back end board ccd detectors integrated perform characterization whole readout chain
human fetal cerebral cortex develops series partially overlapping histogenetic events occur transient cellular compartments subplate zone subplate serves waiting compartment cortical afferent fibers major site early synaptogenesis neuronal differentiation hub transient fetal cortical circuitry thus subplate important hitherto neglected role human fetal cortical connectome subplate also important compartment radial tangential migration future cortical neurons review diversity subplate neuronal phenotypes involvement cortical circuitry discuss complexity late neuronal migration subplate well potential relevance pathogenesis migration disorders cortical dysplasia migratory neurons may become misplaced within subplate easily survive involved early subplate circuitry enhance subsequent survival even immature abnormal physiological activity misrouted connections thus survive adulthood thus better understanding subplate developmental history various subsets neurons may help elucidate certain types neuronal disorders including accompanied epilepsy
compare two approaches construction thermodynamics one dimensional periodic system spinless point bosons yang yang approach new approach proposed author latter elementary excitations introduced one type excitations opposed lieb approach two types excitations particle like hole like weak coupling excitations bogolyubov type equations thermodynamic quantities approaches different solutions coincide shown main result moreover new approach simpler important point thermodynamic formulae new approach values parameters formulae ensemble quasiparticles bose statistics whereas formulae traditional yang yang approach fermi like one particle form
objective international task force recommended disease remission minimal disease activity mda target treatment psoriatic arthritis psa remission mda attained within months initiating medication aim study establish proportion patients psa achieve mda months methotrexate mtx treatment methods patients initiated mtx naive biologics included primary outcome achievement mda months mtx defined presence least following tender joint count swollen joint count sjc psoriasis area severity index pasi body surface area tender entheseal points health assessment questionnaire score patient global disease activity visual analog scale vas score patient pain vas patients identified treated mtx least months sufficient data analysis months results months patients achieved mda patients achieved sjc pasi achieved patient global disease activity criterion lower back pain dactylitis associated lower probability achieving mda conclusion mtx use achieves mda months patients compares unfavorably data tumor necrosis factor inhibitor use
much global canine population overweight adversely affect health lifespan quality life undesirable behaviours also common pet dogs adversely affect welfare well stressful owners however links obesity behavioural disorders never previously explored online survey conducted june august coinciding broadcast national television programme exploring dog health welfare behaviour information gathered included signalment overweight status prevalence range undesirable behaviours fisher exact test used determine associations overweight status owner reported behaviours total responses received data verification final dataset comprised dogs reported owners overweight owners overweight dogs likely see baby allow sleep bed overweight dogs also likely guard food steal food undesirable behaviours commonly reported overweight dogs included barking growling snapping strangers dogs fearful outdoors always coming back called finally owners likely report unsociable behaviours adversely affected dog health overweight status associated number undesirable behaviours dogs studies required explore reasons associations
recent epidemiological evidence reveals patients suffering type diabetes mellitus tdm often experience significant decline cognitive function approximately cases eventually develop alzheimer disease although several pathological processes shared tdm exact molecular mechanisms connecting two diseases poorly understood aggregation human islet amyloid polypeptide hiapp pathological hallmark tdm also detected brain tissue associated cognitive decline development addition hiapp amyloid protein share many biophysical physiological properties well exert similar cytotoxic mechanisms therefore important examine possible role hiapp pathogenesis article introduce basics amyloidogenic protein importantly discuss potential mechanisms hiapp induced development beneficial proposing novel feasible strategies optimize prevention treatment diabetics elsevier ltd rights reserved
blackspot subsurface potato damage resulting impacts harvesting type bruising represents substantial economic losses every year tubers show external symptoms bruise detection potatoes straightforward therefore nondestructive accurate method capable identifying bruised tubers needed hyperspectral imaging hsi shown able detect subsurface defects bruises apples method nondestructive fast fully automated therefore potential non destructive detection blackspot potatoes investigated study two hsi setups used one ranging named visible near infrared vis nir another covering range called short wave infrared swir samples belonging different varieties divided two groups bruises manually induced samples analyzed bruising pca simca pls used build classifiers pls model performed better simca achieving overall correct classification rate hyperspectral setups furthermore accurate results obtained swir setup tuber level allowing identification early bruises within bruising moreover pixel based pls model achieved better results swir setup terms correctly classified samples suggesting possible detect blackspot areas potato tuber high accuracy elsevier ltd rights reserved
cpm pert well established main tools plan control construction projects however planning control construction field operations consider minute minute complexity bringing multiple resources together produce work package level quality resource major effects productivity quality safety rapidly changing dynamic nature site shifting quality critical factors requires new model achieve zero process waste paper presents new construction management model embraces waste based feed forward control methodology designed eliminate process muda waste rather high productivity extends concept seven mudas taiichi ohno include construction specific wastes special interest discussed work waste effect poor communication along supply chain discussing rational model paper highlights results field observations area foundations steel construction wireless cameras used continuous time studies measure productive wasted labor hours changes material supply logistics implemented
sexual transmission hiv aids increasing iran main route infection among women order foster development future hiv prevention interventions women researchers need understand factors influence sexual risk reduction behaviors group aim study explore predictors condom use among women risk hiv develop model condom use sample women risk hiv cross sectionally examined predictors condom use among women risk hiv women recruited drop centers voluntary counseling testing centers tehran condom use among women risk hiv examined using path analysis fit indices showed good fit model condom use self efficacy social support less stereotypic gender roles influenced sexually protective behaviors women risk hiv results provide basis future gender specific intervention programs among women risk hiv researchers practitioners organizations play central role protecting health population make use results benefit sexual reproductive health programs
correlation vitro inhibition cathepsin catk activity vivo suppression collagen biomarkers examined three selective catk inhibitors explore potential translatability animal species human inhibitors exhibited good vitro potencies toward recombinant catk enzymes across species values ranging vivo studies conducted animal species following multiple day dosing catk inhibitors achieve steady state plasma drug concentration time profiles measurement urinary bone resorption biomarkers cross linked terminal telopeptide helical peptide type collagen revealed drug concentration dependent suppression biomarkers values estimated marked improvement correlation vitro vivo catk activities observed application unbound free fraction plasma consistent conditions stipulated free drug hypothesis results indicate vitro vivo translation catk inhibition observed animal species translate humans unbound fraction inhibitor considered interestingly residual levels urinary bone resorption marker detected suppression reached saturation average inhibition apparent phenomenon observed regardless species biomarker compound examined since cathepsin enzymes catk reported catalyze cleavage collagen hypothesized catk mediated degradation collagen bone represents similar overall collagen turnover body
paper proposes bidirectional three level llc resonant converter new pulse width amplitude modulation control method different control signals three different operation modes different voltage gains therefore achieve wide voltage gain range switching among three modes attractive energy storage system applications needing wide voltage variation proposed topology operates constant switching frequency easy implement digital control achieve soft switching switches diodes circuit conventional llc resonant converter performance proposed converter validated experimental results prototype maximum output current
objective hypothalamic gonadotropin releasing hormone pulse generator pituitary gonadotropes ovaries uterus play crucial role female fertility decline reproductive performance represents complex interplay actions levels hypothalamic pituitary ovarian axis recently field female reproductive aging attention drawn carbonyl stress theory advanced glycation end products ages contribute directly protein damage induce chain oxidative stress reactions increase inflammatory reactions highlight mechanisms underlying glycation damage ovary methods searches electronic databases performed articles relevant possible role ages receptor age rage aging ovary summarized interpretive literature review results follicular microenvironment undergoes increase aging data support role ovulatory dysfunction ages well recognized mediators increased rage age modified proteins activated nuclear factor kappa expressed human ovarian tissue suggested accumulation ages products level ovarian follicle might trigger early ovarian aging could responsible reduced glucose uptake granulosa cells potentially altering follicular growth moreover impaired methylglyoxal detoxification causing relevant damage ovarian proteome might one mechanisms underlying reproductive aging conclusions investigation role age rage axis ovarian follicular environment needed results could relate assisted reproduction technology outcomes new measures ovarian reserve
vibrations unknown time varying frequencies significantly affect achievable performance control systems particularly precision engineering manufacturing applications paper provides overview disturbance observer based adaptive vibration rejection schemes studies several new results algorithm design discusses new applications semiconductor manufacturing show construction inverse model based controller parameterization discuss benefits decoupled design algorithm tuning parameter adaptation also studied formulation recursive least squares output error based adaptation algorithms well corresponding scopes applications experiments wafer scanner testbed semiconductor manufacturing prove effectiveness algorithm high precision motion control copyright john wiley sons ltd
increasing emergence ambient intelligence sensors wireless network technologies robotic assistance becomes active area research autonomous intelligent systems robotic systems would integrated environment physical autonomous entities entities able interact independently ambient environment provide services assistance people homes offices buildings public spaces furthermore robots cognitive entities able coordinate activities physical logical entities move feel explore surrounding environment decide act meet situations may encounter cognitive operations part smart network provide individually collectively new features various support services anywhere anytime aim research work build multimodal fusion engine using semantic web multimodal system applied wheelchair manipulated arm help people disabilities interact main tool movement environment work focuses building multimodal interaction fusion engine better understand multimodal inputs using concept ontology authors published elsevier
chronic inflammatory bowel disease ibd increasingly recognized children adolescents particularly countries withwestern lifestyle timely diagnosis therapy significant impact long term outcome disease close cooperation pediatricians pediatric gastroenterologists necessary absence infectious causes ibd must excluded cases chronic recurrent symptoms increased concentrations inflammatory markers feces calprotectin sensitive active ibd specific diagnostic work essentially includes endoscopy small bowel imaging addition pharmaceutical treatment nutritional therapy crohn disease new biologicals immunomodulators available tailor treatment modalities knowledge drug effects potential side effects drug interactions individual risk factors ibd phenotype well disease activity required
increased interest materiality analytical category social sciences provide construction management economics scholar new possibilities better exploit detailed empirical data collected construction industry related fields constructivist idealist theories tended dominate social sciences since least mid sixties social sciences sought release methodological dogmatism hard sciences materiality recognized subject theorizing within different social science traditions article advocates broad engagement materiality within construction management research presents series analytical concepts empirical studies stress built environment human beings inhabit far passive inert stable common sense thinking easily misleads analysts believe image materiality recognizes agential dynamic fluid nature materiality thus arguably conducive intellectually stimulating construction management scholarship
dimensional zakharov equations arising propagation laser beam plasma studied paper analytic soliton solutions obtained means symbolic computation based find vertical bar vertical bar inversely related omega positively related inversely related cope cob positively related envelope high frequency electric field plasma density omega omega plasma electronic frequency frequency laser beam mean density plasma mass ion ion sound velocity plasma respectively head interaction found transformed overtaking one omega increasing decreasing also period bound state interaction decreases omega decreasing considering driving forces laser induced plasma explore associated chaotic motions well effects omega omega omega omega wave number laser beam omega cope represent frequencies driving forces respectively found chaotic motions weakened omega omega increasing omega decreasing periodic motion occur cope reaches critical value chaotic motions independent omega elsevier ltd rights reserved
half pregnancies usa unintended suggesting high incidence either improper nonuse contraceptives emergency birth control ebc provides individuals additional insurance unplanned pregnancy presence contraception failure study first estimate impact switching ebc prescription nonprescription status usa abortions risky sexual behavior measured std rates utilizing state level variation access ebc find providing individuals counter access ebc leads increase std rates effect abortion rates moreover individual level analysis using national longitudinal survey youth indicates risky sexual behavior engaging unprotected sex number sexual encounters increases result counter access ebc consistent state level std findings copyright john wiley sons ltd
chronic kidney disease ckd defined egfr min affects united states population addition estimated approximately population early evidence ckd likely progress end stage renal disease esrd near future esrd common many ethnic minorities african americans highest rates treated esrd closely followed hispanic americans compared non hispanic white persons although african americans ckd likely die non hispanic white persons ckd trends reverse progression esrd established reasons disparities prevalence incidence ckd esrd mortality unclear likely involve complex interaction socioeconomic environmental genetic factors review highlights current data pertaining social economic impact ethnic differences prevalence incidence ckd esrd united stated hoped highlighting current trend kidney related health disparities lead improved understanding issues also informed research agendas ultimately aimed alleviating ethnic differences kidney health outcomes
virtual clothes try recently come researchers focus owing commercial potential used efficient tool online shopping allowing users narrow choices designs sizes study real virtual clothes try system proposed makes possible users see virtual monitor wearing virtual clothes without taking real clothes tool also allows users choose various clothes try important point paper using motion skeleton capture sensor user body measurements computed comparing computed body sizes measurements body size standards user body size estimated via expert system data used proper clothes fitting clothes simulation virtual try system clothes selected hand motion clothing list screen users thus view clothing choice virtually displayed body study contributes current literature offering original approach brings new perspective body scanning body determination virtual clothing simulation clothing sector
leadership energy environmental design leed green building certification program dedicated design sustainable buildings incentivizing reductions energy water building materials consumption time enhancing occupant health overall community connectivity green buildings certified program reduce environmental footprint buildings must also designed resilience withstand external stressors may arise buildings lifetime truly sustainable therefore resilient building able adapt remain functional pressure frequent severe climatic events goal study analyze existing inherent overlaps resilient design principles leed certification system synergistic opportunities together improvements better integrating resilient design leed checklist hence green buildings modifying existing proposing new credits discussed use climate projections instead historical climate data design recommended regional priority credits need specified address unique regional needs project improve resilience light particular region future climate outlook
building stakeholders owners tenants operators designers understand impacts indoor air quality iaq associated energy costs unknown surveyed stakeholders across united states ascertain perceptions current iaq estimates benefits costs well willingness pay iaq improvements respondents perceived iaq scores correlated use high efficiency filters iaq improving technologies elicited estimates impacts ventilation filtration upgrade vfu doubling ventilation rate cfm person person upgrading minimum efficiency reporting value filter compared responses estimates derived iaq literature energy modeling minorities respondents thought vfu would positively impact productivity absenteeism health respondents annual vfu cost estimates mean median per person much higher always per person yearly cost plurality respondents said would pay vfu per person respondents holding green building credentials likely affirm iaq benefits vfu less likely willing pay
purpose aim study increase efficiency enterography using time driven activity based costing methodology methods february multidisciplinary team formed identify personnel equipment space supply costs providing outpatient enterography team mapped current state completed observations performed timings calculated costs associated element process team used pareto charts understand highest cost time consuming activities brainstormed opportunities assessed impact plan study act cycles developed test changes run charts used monitor progress process changes consisted revising workflow associated preparation administration glucagon completed implementation november results time driven activity based costing methodology allowed radiology department develop process accurately identify costs providing enterography primary process modification reassigning responsibility administration glucagon nurses technologists implementation improvements demonstrated success reducing non value added steps cost staff time patient process time saved process time used augment existing examination time slots accurately accommodate entire enterographic examination anecdotal comments captured validate improved staff satisfaction within multidisciplinary team conclusions process provided successful outcome address daily workflow frustrations could previously improved multidisciplinary team necessary achieve success addition use structured problem solving approach american college radiology
inflammation ubiquitous factor accompanying normal aging neurodegeneration recent studies indicate major contribution inducible cyclooxygenase cox downstream prostaglandin signaling pathways modulating neuroinflammatory responses neuronal function previously shown prostaglandin pge receptor suppresses innate immune responses models systemic inflammation investigated role receptor models parkinson disease systemic administration agonist ono neurotoxin methyl phenyl tetrahydropyridine mptp prevented loss dopaminergic neurons substantia nigra pars compacta snpc without significant changes glial activation suggesting potent neuroprotective effect signaling acute model neuronal loss cell specific conditional ablation cdbcre lox lox mice exacerbated mptp associated glial activation cell infiltration snpc consistent anti inflammatory functions microglial signaling vitro primary microglia stimulated oligomeric alpha synuclein receptor activation suppressed generation pro inflammatory oxidative stress factors taken together findings suggest dual neuroprotective anti inflammatory mechanism action receptor models
aim study evaluate role demographic mental health substance use risk factors intimate partner violence ipv data derived wave national epidemiological survey alcohol related conditions eligible participants reported intimate partner year survey clustered survey multivariate multinomial regression methods used assess risk factors episodes ipv ipv victimization perpetration victims perpetrators assessed bivariate analyses indicated african americans hispanics women likely victims perpetrators victim perpetrators compared men whites multivariate analyses suggested marijuana use disorder strongly associated ipv victimization odds ratio victim perpetration post traumatic stress disorder consistently associated ipv typologies depression associated victimization ipv victim perpetration antisocial personality disorder mania related ipv perpetration ors victim perpetration ors results also indicated alcohol use episodes ipv common reported ipv also reported alcohol involved results indicate several substance mental health related correlates ipv addition findings indicate alcohol use victim perpetrator common ipv events policy implications directions future research discussed
paper presents new adaptive mesh refinement strategy offers alternative classic amr methods automatic local refinement needs additional storage good cpu time results makes fine candidate specific studies applied fluid structure interaction problem prediction behavior submerged net fisheries applications fishing companies scientific questioning indeed structure code modeling net already uses lot memory space introduce scheme require data structure original algorithm employs local numbering cells identify neighbor every cell auto adaptive mesh applied fluid model test case describing hydrodynamic behavior netting panel published elsevier ltd
previous research demonstrated critical role communication plays group ability recognize expert members study looks broadly different forms communication might influence expertise recognition considers structural relational communicative factors related individuals success expertise recognized group members addition advance view expertise recognition terms expertise sharing consider circumstances individual self perceived expertise likely match perceptions group members drawing survey data employees financial services company find communication practices structural influences primarily relate group members expertise recognized coworkers findings extend theory views attributions individuals expertise organizations communicative phenomenon emerges work practices
paper deals dissipativity stability chaotic behavior related structural properties relatively broad class finite dimensional strictly causal systems class nonlinear systems consideration described state space representation form system properties investigated new approach based new abstract state energy concept proper generalization well known tellegen theorem form energy conservation principle resulting energy function induced output signal power determines structure proper system representation well corresponding system state space topology state minimality well parameter minimality requirements plays crucial role proposed method several examples solved results simulation shown illustration fundamental ideas basic attributes proposed method
study objectives investigate whether realistic dose shortened sleep relative well rested state causes decline adolescents learning increase inattentive sleepy behaviors simulated classroom setting methods eighty seven healthy year olds underwent week sleep manipulation protocol including two night sleep manipulation conditions presented randomly counterbalanced within subjects cross design wake time held constant bedtimes set induce short sleep hours bed versus healthy sleep hours bed morning end condition participants underwent simulated classroom procedure viewed lecture based educational videotapes completed relevant quizzes behaviors simulated classroom later coded condition blind raters evidence inattention sleepiness results adolescents longer average sleep period hours hours compared scores adolescents scored significantly lower quiz showed behaviors suggestive inattention sleepiness simulated classroom reported adolescents parents inattentive sleepy however impact manipulation quiz scores mediated changes attention sleepiness conclusions although effect sizes modest findings suggest previously reported correlations sleep duration academic performance reflect true cause effect relationships findings add growing evidence chronically shortened sleep experienced many adolescents school nights adversely impacts functioning health
coronary heart disease chd common complex disease resulting interaction multiple environmental genetic factors assess potential relationship vascular endothelial growth factor vegfa polymorphisms chd risk comprehensive meta analysis conducted systematic search embase pubmed online database publications vegfa polymorphisms risk chd carried crude odds ratios ors confidence intervals cis calculated determine association total ten publications including trails involving cases controls included pooled analysis overall results present meta analysis demonstrated significant association vegfa polymorphism increased risk chd stratifying ethnicity chd type association also obtained significant association vegfa polymorphism risk chd also found vegfa polymorphism polymorphism associated risk conclusion findings suggest vegfa polymorphisms risk factors chd future large sample size well designed epidemiologic studies needed confirm conclusions
paper presents sensorless control variable speed wind turbine operating partial load order eliminate direct measurement wind speed proposal estimated aerodynamic torque used determine optimal reference speed control maximum energy conversion maximization efficiency energy conversion minimization detrimental dynamical loads control trade offs considered design optimal discrete time feedback lqg ltr controller wind energy conversion system wecs based optimization quadratic cost function performance proposed control submitted gust step variation wind speed evaluated computational simulations also presented proposals sensorless control electrical generator elsevier ltd rights reserved
backgroundextensive evidence documents geographic variation spending limited research assesses geographic variation quality particularly among commercially insured enrollees objectiveto measure geographic variation quality measures correlation among measures correlation measures spending commercially insured enrollees data sourceadministrative claims truven marketscan database methodswe calculated variation correlations among quality measures across hospital referral regions hrrs adjusting beneficiary traits sample size differences created quality index correlated spending resultsthe coefficient variation hrr level performance ranged correlations among quality measures generally ranged quality modestly positively related spending conclusionquality varied across hrrs modest geographic quality footprint
dramatic consumption reduction integrated circuits related development mobile electronic devices reached past years enabling use ambient energy instead batteries focus transformation ambient mechanical vibrations electrical energy paper compares performances vibration powered electrical generator using pzt piezoelectric ceramics associated two different power conditioning circuits new approach piezoelectric power conversion based nonlinear voltage processing presented implemented using particular circuit theoretical predictions experimental results show new technique may increase power harvested factor compared standard technique power optimization problem particular examined case broadband random vibrations
background project engineered discharge red evidence based strategy reduce readmissions disseminated adapted various health systems across country date little known adapting project red original protocol impacts red implementation sustainability goal study identify characterize contextual factors influencing five california hospitals adapted implemented red subsequent impact red program sustainability methods participant observation key informant focus group interviews individuals five california hospitals implementing red conducted involved hospital leadership personnel responsible project red implementation hospital staff clinicians interview transcripts coded analyzed using modified grounded theory approach constant comparative analysis results internal external contextual factors identified influenced hospitals decisions red adaptation implementation also impacted red sustainability external factors included impending federal penalties hospitals high readmission rates targeting specific diagnoses access external funding technical support help hospitals implement red internal organizational level contextual factors included committed leadership prioritizing project red red adaptations depth accountability influence implementation team sustainability planning hospital culture three five hospitals continued project red beyond implementation period conclusions sustainability red participating hospitals possible hospitals approached red implementation transformational process rather patient safety project maintained high level fidelity red protocol leadership implementation team embraced change failure pursuit better patient care outcomes hospitals unsuccessful implementing sustainable red process lacked components approach
designated confirmer signature dcs introduced chaum eurocrypt used control public verifiability digital signature useful tool many applications require signature remain anonymous unverifiable certain time condition reached paper propose new generic construction anonymous identity based dcs anonymous identity based signature interestingly construction also automatically implies anonymous identity based convertible undeniable signature scheme prove construction secure signer verifier confirmer standard model
statistical data management center sdmc provides antibacterial resistance leadership group arlg statistical data management expertise advance arlg research agenda sdmc active stages study including design data collection monitoring data analyses archival publication study results sdmc enhances scientific integrity arlg studies development implementation innovative practical statistical methodologies educating research colleagues regarding application clinical trial fundamentals article summarizes challenges roles well innovative contributions design monitoring analyses clinical trials diagnostic studies arlg sdmc
experimental modal analysis aims identifying modal properties natural frequencies damping ratios mode shapes structure using vibration measurements two basic questions encountered operating frequency domain mode near particular frequency much spectral data near frequency included modal identification without incurring significant modeling error data high signal noise ratios questions addressed using empirical tools singular value spectrum otherwise generally open challenging modes low sin ratios close modes work questions addressed using bayesian approach focus operational modal analysis output ambient data identification uncertainty modeling error significant control demanding approach leads evidence ratios quantifying relative plausibility competing sets modeling assumptions latter involves modeling situation non trivial resolved systematic consideration alternative models using maximum entropy principle synthetic field data considered investigate behavior evidence ratios interpreted practical applications elsevier ltd rights reserved
study design cross sectional survey objective aim study compare patients physiotherapists views triggers low back pain lbp identify novel factors previously reported summary background data research risk factors lbp guided views clinicians researchers patients consequently potentially valuable information risk factors lbp available suffering condition study aimed compare patients physiotherapists views triggers lbp identify novel factors previously reported methods one hundred two physiotherapists patients sudden acute episode lbp participated study participating physiotherapists asked nominate likely short term risk factors trigger lbp episode similarly patients asked thought triggered onset lbp responses coded risk factor categories subcategories independent researchers endorsement category compared using pearson chi square statistic results patients physiotherapists endorsed biomechanical risk factors important risk factor category respectively similar levels endorsement top subcategories lifting bending prolonged sitting significant differences endorsement awkward postures sports injuries physical trauma unaccustomed activity patients physiotherapists respectively conclusion overall patients physiotherapists views remarkably similar patients physiotherapists endorsed lifting important trigger lbp agreed top lifting bending prolonged sitting new risk factors suggested patients level evidence
cloud computing internet based computing virtual shared servers provide software infrastructure platform resources customer pay use basis cloud computing increasingly becoming popular many enterprise applications data moving cloud platforms however enormous use cloud probability occurring intrusion also increases major need bringing security transparency reliability cloud model client satisfaction one security issues reduce impact type intrusion environment address issue security solution proposed paper provide collaborative framework hybrid intrusion detection system ids based mobile agents virtual firewalls therefore hybrid intrusion detection system consists three types ids namely ids ids ids dispatched three layer cloud computing first layer use ids framework collect analyze detect malicious data using mobile agents case attack collect level second layer malicious data detected first layer generation new signatures using ids based signature generation algorithm sga network intrusion detection system nids finally ids placed third layer new signatures used update database nids belonging ids database nids belonging ids cluster neighboring also ids hardware firewall unable control communication virtual machines hypervisor moreover blind virtual traffic mostly deployed virtual machine monitor level vmm cloud provider control equally mobile agents play important role collaboration used framework investigation hosts transfer data malicious transfer update database neighboring ids cloud technique neighboring ids use new signatures protect area control type attack type close loop control collaborative network security management framework identify address new distributed attacks quickly effectively
nonlinearities dynamical behavior mechanical systems degrade performance damage detection features based linearity assumption article discrete volterra model used monitor prediction error reference model representing healthy structure kind model separate linear nonlinear components response system property model used compare consequences assuming nonlinear model nonlinear regime magneto elastic system hypothesis tests employed detect variations statistical properties damage features analyses conclusions made application volterra series damage detection
backgroundrecommended management attacks hereditary angioedema hae due esterase inhibitor inh deficiency inh hae includes therapy exogenous cinh thrombotic thromboembolic events tee reported plasma derived cinh far none recombinant human cinh rhcinh phase iii randomized placebo saline controlled study evaluated safety rhcinh treatment acute attacks patients inh hae methodsmonitoring tee assessment risk deep vein thrombosis dvt wells prediction rule performed levels fibrin degradation products plasma dimers assessed study drug administration baseline days posttreatment resultsplasma dimer levels elevated patients median percentiles normal higher patients submucosal abdominal oropharyngeal laryngeal attacks compared subcutaneous peripheral facial attacks median plasma dimer levels comparable across treatment groups baseline rhcinh saline postinfusion rhcinh saline median plasma dimer levels decreased day groups rhcinh saline increased risk dvt identified tee reported rhcinh treated controls conclusionelevated plasma dimer levels associated acute inh hae attacks particularly submucosal involvement however rhcinh therapy associated thrombotic events
optical imaging methods significant potential effective intraoperative tools visualize tissues cells biochemical events aimed objective assessment tumor margin guiding surgeon adequately resect tumor sparing critical tissues wide variety approaches guide resection range parameters detect interdisciplinary nature involving biology chemistry engineering medicine suggested need organization could review discuss refine help prioritize methods optimize patient care pharmaceutical instrument development address issues world molecular imaging society created optical surgical navigation osn interest group bring together scientists engineers surgeons develop field benefit patients provide overview approaches currently clinical investigation optical surgical navigation offer perspective upcoming strategies
objective compare united nations programme hiv aids unaids modelled estimates adult mortality sub saharan africa empirical estimates design age specific mortality rates obtained nationally representative sibling survival data recent household deaths vital registration directly compared unaids estimates orphanhood prevalence derived unaids mortality estimates compared survey census reports survival children parents methods age specific mortality rates adults aged years calculated demographic health surveys deaths reported censuses vital registration adjusted underreporting whenever possible proportions orphans extracted censuses surveys children aged years results unaids estimates significantly higher sibling mortality estimates except among men countries high hiv prevalence better agreement rates based household deaths vital registration model outputs sex ratios adult mortality lower unaids estimates modelled orphan prevalence significantly higher surveys censuses exception paternal orphans countries high hiv prevalence ratios paternal maternal orphans lower unaids model surveys censuses among women increases mortality due aids concentrated age range years model outputs compared empirical estimates conclusion discrepancies levels sex ratios age patterns adult mortality empirical unaids estimates call additional data quality assessments improvements estimation methods copyright wolters kluwer health inc rights reserved
atp binding cassette transporter abca expressed hippocampus cortex brain confirmed involved development alzheimer disease previous studies demonstrated abca regulated beta production lipid transport leading characteristic pathological changes however role mechanism abca context needs research augmented expression abca using lentiviral vector carrying abca gene investigate effect abca overexpression mice explored underlying mechanism vitro present study abca expressed successfully hippocampus mice lentiviral vector mediating abca gene showed abca overexpression effectively improve cognitive behavior mice diminished beta production meanwhile abca overexpression significantly relieved neurotoxicity beta promoting cell viability reducing endoplasmic reticulum stress conclusion findings showed abca obvious anti beta effect appeared improve cognitive function mice results provided new thought basic scientific data clinical treatment
background caregiving schizophrenia demanding exhausting activity challenges physical emotional resources family caregivers traditional societies india compounded illiteracy ignorance religious cultural explanations attributed mental illness aims study aimed assess primary caregivers persons schizophrenia terms perceived burden manifestation psychological distress quality life qol methods study used quantitative cross sectional design survey methodology collect data caregivers hospital setting thanjavur india standardized instruments used collect data patients caregivers results high perceived burden lower qol seen majority caregivers also manifested high levels anxiety depression patient characteristics age gender symptoms duration illness influence perceived burden caregivers positive negative symptoms duration illness correlated qol conclusions findings indicate need intervention family caregivers enable cope effectively demands caregiving psychoeducation participation peer support groups advocated low resource effective outcome strategies caregivers india
objectives study aimed compare cost effectiveness botox anticholinergic medications management urgency urinary incontinence uui methods cost effectiveness data analyzed participants anticholinergic versus botox comparison randomized trial daily medication versus intradetrusor botox injection societal costs included following treatment costs patient costs medical nonmedical utilization month trial quality adjusted life years qalys calculated based questionnaire derived utility measures annualized based data collected baseline months also estimated average direct costs treatment months duration time approximately half botox participants maintained adequate symptom control results data analyzed women completed month follow anticholinergic versus botox comparison trial botox mean reduction uui episodes per day significantly different per group cumulative mean direct costs first months also similar group botox group costs exceeding botox costs months groups considerable qaly gains annualizing month trial results month measure botox groups averaged qalys respectively estimates months favored botox showing participants incurred higher cost per month adequate symptoms control compared botox participants conclusions botox medications similar costs effectiveness first months uui treatment costs outcomes considered months botox may significantly lower costs similar uui symptom control
objectives understand women preferences specific features contraceptive methods extent features existing methods match women preferences whether match differs racial ethnic subgroups study design using data women family planning abortion clinics across united states performed analyses racial ethnic differences contraceptive features reported extremely important participants explored preferences vary less effective contraceptive methods results multivariate analysis non hispanic black latinas asian pacific islander women likely report following features extremely important compared non hispanic whites able stop using method time using method intercourse method changing menstrual periods non hispanic black latina women statistically likely report protection sexually transmitted diseases control whether use method able become pregnant stopping use extremely important contraceptive feature preferences racial ethnic minority women study relatively lower match high efficacy methods higher match low efficacy methods compared white women conclusions high rates unintended pregnancy among minority women may due part differences contraceptive features preferences discrepancy preferences features currently available highly effective methods elsevier inc rights reserved
due fact effective rational approximation fractional operator necessary practical application rational approximation order fractional operator constructed take approximation transfer function circuit order fractance intended test performance approximation algorithm designed realized elements fractional control system made fractance given bode diagram nichols diagram illustrated frequency character time domain character initial value problem illustrated state equation system effectiveness good performance proposed method proved calculation example frequency time domain
work place engineering problems recognized complex ambiguous however problems students asked solve degree programs classroom problems studies ambiguity problem solving defined ambiguity characteristic problems interested understanding students interpret engineering problems either creating resolving ambiguity problem solving process research question guides study ambiguity manifested engineering students solve problems study part larger project examining engineering students engineering problem solving across different types engineering problems twenty materials engineering students asked solve four materials engineering problems think aloud session analysis points ambiguity problem solving process identified periods students specifically verbalized uncertainty points ambiguity transcript analyzed script analysis specifically textual instances ambiguity linked three main periods situational categories situation caused ambiguity happened point ambiguity reaction student reaching point ambiguity results indicated students experienced points ambiguity closed open ended problems several motifs common types problems including confusion use given values necessary content knowledge lack self confidence difficulty conceptualizing problem lack constraints inherent open ended problems also caused additional ambiguity among students findings show ambiguity take many forms function problem structure students reach points ambiguity points know next due many factors factors represent aspects academic epistemological development analysis date suggests students need comprehensive training practice prepared facing problems reflect work engineering practice currently examining data identify patterns response ambiguity may help developing pedagogical strategies tools support students ability successfully solve engineering problems
long term studies midurethral sling mus procedure patients preoperative detrusor overactivity debate regarding usefulness preoperative cystometry study designed provide long term efficacy safety data advantage mus compare outcomes patients pure urodynamic stress incontinence usi outcomes patients mixed usi retrospective consecutive case series study patients usi usi group matched consecutive group patients preoperative usi mixed group treated retropubic mus outcomes assessed using king health questionnaire patient global impression improvement questionnaire mean follow years patients usi group described much better much better usi group mixed group quality life improved years baseline groups patients mixed group likely complain urgency likely severe repeat mus procedure needed patients needed surgical removal mus persistent troublesome pain study suggests preoperative diagnosis affects long term patient perceived outcome mus procedure however patients significant long term improvement quality life
objective patients constipation account million physician visits year care costs patients irritable bowel syndrome constipation ibs chronic idiopathic constipation cic compared general public received little study study aim describe healthcare utilization compare medical costs patients ibs cic matched controls community based sample methods nested case control sample ibs cic cases matched controls case group selected olmsted county individuals responding community based survey gastrointestinal symptoms received healthcare participating rochester epidemiology project rep provider using rep healthcare utilization data unadjusted adjusted standardized costs compared year periods prior survey ibs patients controls cic patients controls two time periods chosen conditions episodic long term results outpatient costs ibs cic patients year period prior survey significantly higher controls respectively adjusting morbidities age sex ibs outpatient costs emergency room costs significantly higher controls respectively year period prior unadjusted data analyses cases compared controls demonstrated significantly higher imaging costs ibs cases procedure costs cic cases year period limitations data collected random community sample primarily receiving care limited number providers area conclusions patients ibs cic significantly higher outpatient costs year period compared controls ibs patients also higher costs general population
context carboxymethyl lysine cml results oxidative stress linked cardiovascular disease objective objective study investigate association sleep disordered breathing sdb source oxidative stress cml materials methods participants cardiovascular health study chs studied results women sdb significantly higher cml concentration compared without sdb association significant among men discussion sdb associated cml concentration among elderly women men cardiovascular health study conclusion accumulation cml may adverse health consequence sdb
thiswork molecular dynamics simulationmethodwas introduced compute preassembled system molecular imprinted polymers sulfamethoxazole monomer results revealed ratio sulfamethoxazole template molecule aminopropyltriethoxysilane functional monomer tetraethylorthosilicate cross linker led themost stable template functionalmonomer cluster based result computational simulation cdte sio core shell imprinted polymers cadmium telluride quantum dots layer surface aminofunctionalized sio synthesized fluorescent sensor series measures used characterize structure morphology get optimal sensors concentration range mol molecular imprinted polymers cdte sio sulfamethoxazole fluorescence intensity verify reliability accuracy fluorescent sensor application successfully analyzing sulfamethoxazole pure milk lake water results showed recoveries relative standard deviation fluorescence sensor selective recognition provides alternative solution determination sulfamethoxazole
paper proposes alternative way characterize pore structure cement pastes using innovative non contact impedance measurement methodology based pore fractal theory fractal dimension pore space solved two networks fractal electrical network pore structure network minimal pore diameter pore fractal theory evaluated electrical double layers model applicable scope non contact impedance measurement addressed frequency dispersion mechanism pore fractal theory impedance measurement relationship cumulative pore volume impedance response cement pastes revealed elsevier ltd rights reserved
objective assess year risk cardiovascular disease potential impacting factors among patients undergoing hemodialysis yaounde cameroon design cross sectional study january setting patients recruited dialysis unit yaounde university teaching hospital cameroon participants hemodialysis patients aged years dialyzing unit since least months volunteering enrolled study main outcome measures risk cardiovascular disease assessed using framingham risk score results included patients risk cardiovascular disease ranged less median interquartile range twenty hemodialysis patients low risk cardiovascular disease multivariable linear regression analysis duration dialysis adjusted beta number weekly sessions physical activity adjusted beta fasting serum glucose levels adjusted beta serum triglycerides levels adjusted beta serum urea levels adjusted beta independently impacting patients risk cardiovascular disease conclusion around study population presented moderate high risk cardiovascular disease duration dialysis number physical activity sessions per week fasting serum glucose serum triglycerides serum urea levels may impact hemodialysis patients risk cardiovascular disease
many computer graphics rendering algorithms techniques use ray tracing generation photo realistic images tree popular acceleration data structure ray tracing order avoid inefficient parallel performance tree construction based surface area heuristic sah algorithm using morton code path compression present paper instead building tree layer layer proposed approach performed parallel bottom conceptual perfect binary tree experimental results gpu show work achieves faster tree construction procedure
background canadian network mood anxiety treatments canmat conducted revision guidelines updating evidence recommendations scope guidelines remains management major depressive disorder mdd adults target audience psychiatrists mental health professionals methods using question answer format conducted systematic literature search focusing systematic reviews meta analyses evidence graded using canmat defined criteria level evidence recommendations lines treatment based quality evidence clinical expert consensus complementary alternative medicine treatments fifth six sections guidelines results evidence informed responses developed questions broad categories complementary alternative medicine cam interventions physical meditative treatments light therapy sleep deprivation exercise yoga acupuncture natural health products john wort omega fatty acids adenosyl methionine sam dehydroepiandrosterone folate crocus sativus others recommendations based available data efficacy tolerability safety conclusions mdd mild moderate severity exercise light therapy john wort omega fatty acids sam yoga recommended first second line treatments adjunctive exercise adjunctive john wort second line recommendations moderate severe mdd physical treatments natural health products less evidence may considered third line treatments cam treatments generally well tolerated caveats include methodological limitations studies paucity data long term outcomes drug interactions
aim article explore whether psychologists lawyers psychology students would able predict children behave memory suggestibility experiments ability associated different measures experience participants predict results series published research studies pertaining children memory suggestibility results indicated ability participants predict behavior children overall low unrelated experience concluded professionals able assess children functioning witnesses may able
deforming nickel base superalloys gamma solvus retards dynamic recrystallisation drx hampering grain boundary motion efficient way refining grain size forging hot working processes previously proposed model describing kinetics drx nickel alloys developed account influence gamma intermetallics allowing predicting microstructural evolution subsolvus deformation model incorporates alloy composition initial grain size well temperature strain rate calibrated data supersolvus subsolvus deformation plotting calculated steady state grain size function strain necessary complete drx allows visualising processing compositional trends relevant materials engineering used design shown efficient grain refinement achieved limited amount strain process alloy optimisation alone performed instead appears may reached joint design forming process strain rate temperature composition elsevier ltd rights reserved
present robust vector bioimpedance measurement system longitudinal knee joint health assessment capable acquiring high resolution static slowly varying course hours days dynamic rapidly varying order milli seconds bioresistance bioreactance signals occupying area consuming supplied front end achieves dynamic range omega noise floor omega rms resistive omega rms reactive within bandwidth microcontroller allows real time calibration minimize errors due environmental variability temperature experienced outside lab environments enables data storage micro secure digital card acquired signals processed using customized physiology driven algorithms extract musculoskeletal edema cardiovascular local blood volume pulse features knee joint feasibility study found statistically significant differences injured contralateral static knee impedance measures two subjects recent unilateral knee injury compared seven controls specifically impedance lower injured knees supporting physiological expectations increased edema damaged cell membranes second feasibility study demonstrate sensitivity dynamic impedance measures cold pressor test omega decrease pulsatile resistance associated increased downstream peripheral vascular resistance proposed system serve foundation future efforts aimed quantifying joint health status continuously normal daily life
instrumental test black tea samples instead human panel test attracting massive attention recently study focused investigation feasibility estimation color sensory quality black tea samples using vis nir spectroscopy technique comparing performances models based spectra color information model calibration variables first selected genetic algorithm nonlinear back propagation artificial neural network bpann models established based optimal variables comparison models bpann models spectra data information showed best performance correlation coefficient root mean square error prediction set addition models based spectra information provided better performance based color parameters therefore vis nir spectroscopy technique promising tool rapid accurate evaluation sensory quality black tea samples elsevier rights reserved
ambient intelligence ami active topic research gaining attention characteristics transparency intelligence older people one collectives take advantage use ami systems thanks characteristics ami systems focus older adults real needs satisfy one main motivations adapt technological innovations perceived benefits perhaps everything related healthcare home care perceived valuable beneficial paper presented multi agent architecture mas healthcare ami system treat older people motor impairment problems using specific devices control patient movements way natural relationship ami mas widely exploited ami proposes development context aware systems integrate different devices recognize context act accordingly agents provide effective way develop systems since agents reactive proactive exhibit intelligent autonomous behavior one main differences system provides therapist support design new therapies adapt specific person control execution instead using fixed set exercises
enable efficiency stream processing evaluation query usually performed bounded parts potentially unbounded streams processing windows slide streams avoid inefficient evaluations already evaluated parts stream respect query incremental evaluation strategies applied query results obtained incrementally result set preceding processing state without evaluate input buffers method highly efficient comes cost maintain processing state trivial may defeat performance advantages incremental evaluation strategy context rdf streams problem aggravated hard predict evolution structure rdf graphs time application sub optimal implementation approaches using relational technologies storing data processing states incur significant performance drawbacks graph based query patterns address performance problems paper proposes set novel operator aware data structures coupled incremental evaluation algorithms outperform counterparts relational stream processing systems claim demonstrated extensive experimental results simulated real datasets elsevier rights reserved
wireless sensor networks wsns characterized localized interactions protocols often based message exchanges within node direct radio range recognize protocols work effectively nodes must consistent information shared neighborhoods different types faults however affect information severely impacting protocol performance factor problem existing wsn protocols argue notion neighborhood view consistency nvc embedded within existing designs improve performance end study problem theoretical system perspective prove problem solved asynchronous system using chandra toueg failure detectors introduce new software device called pseudocrash failure detector pcd study properties identify necessary sufficient conditions solving nvc pcds prove presence transient faults nvc impossible solve pcds thus define two weaker specifications problem develop global algorithm satisfies specifications presence unidirectional links localized algorithm solves weakest specification networks bidirectional links implement latter atop two different wsn operating systems integrate implementations four different wsn protocols run extensive micro benchmarks full stack experiments real node wsn testbed results show performance significantly improves nvc equipped protocols example collection tree protocol ctp halves energy consumption higher data delivery
paper reviews concept designing open horizontally scalable distributed information computing environment presented form decentralized resource architecture including computing nodes storage nodes communication channels decentralized computations data management distributed infrastructure divided two main components computational cluster storage cluster management cluster assigned specialized frameworks infrastructure manager network manager computing manager storage manager authorization manager web manager upload manager paper shows results practical study processed meteorological parameters obtained standard ultrasonic weather station developed information computational environment
modeling spatial correlation ground motion residuals caused coherent contributions source path site provide valuable loss hazard information well realistic depiction ground motion intensities geological survey usgs software package shakemap utilizes deterministic empirical approach estimate median ground shaking conjunction observed seismic data shakemapbased shaking estimates used concert loss estimation algorithms estimate fatalities economic losses significant seismic events around globe incorporating spatial correlation ground motion residuals shown improve seismic loss estimates particular park bazzuro baker applications statistics probability civil engineering investigated computing spatially correlated random fields residuals however large scale shakemap grids computational requirements method prohibitive work memory efficient algorithm developed compute random fields implemented using shakemap framework new iterative parallel algorithm based decay properties associated ground motion correlation function shown significantly reduce computational requirements associated adding spatial variability shakemap ground motion estimates demonstrate quantify impact adding peak ground motion spatial variability resulting earthquake loss estimates
numerical control system core technology flexible manufacturing system computer integrated manufacturing system paper fully take advantage surface reconstruction technology optimize tool path planning promote performance numerical control system main idea paper utilize non uniform rational basis spline nurbs numerical control system powerful mathematical model describe curves surfaces based computer graphics next provide novel tool path planning algorithm numerical control system based nurbs curve three steps constructing nurbs curve node vector nurbs curve interpolation optimizing fitting control points nurbs curve fitting finally experimental results demonstrate fitting precision greatly enhanced numerical control program also significantly simplified nurbs curve fitting
context higher education competence may understood combination skills knowledge attitudes values abilities underpin effective superior performance professional area aim work reported design set procedures assess transferable competence problem solving basic learning academic professional life crucial engineering study involved total students enrolled three universities two different stages studies development phases assessment device included analysis competence facets design assessment task development criteria rate student performance analysis basic psychometric properties assessment methods area education conclusion drawn training process elaboration scoring criteria costly necessary objectivity interpretation results guaranteed main achievement project development procedure measures learning outcomes specifically problem solving
background improvement postural control persons multiple sclerosis pwms important target neurorehabilitation although pwms able improve postural performance training neural underpinnings improvements poorly understood objective understand neural underpinnings postural motor learning pwms methods supraspinal white matter structural connectivity pwms correlated improvements postural performance balancing oscillating surface trials retention improvements hours later results improvement postural performance directly correlated microstructural integrity white matter tracts measured radial diffusivity corpus callosum posterior parieto sensorimotor fibers brainstem pwms within corpus callosum genu midbody fibers connecting prefrontal primary motor cortices respectively strongly correlated improvements postural control twenty four hour retention correlated radial diffusivity conclusion pwms exhibited poorer white matter tract integrity connecting cortical hemispheres via corpus callosum showed difficulty learning control balance unstable surface prediction improvements postural control training motor learning via structural imaging brain may allow identification individuals particularly well suited postural rehabilitation interventions
ambient vibration tests analyses long span rigid frame bridge conducted using distributed long gauge fiber optic sensors concept long gauge fiber optic sensor merit reveal local global structural features presented monitoring long span bridge performed using long gauge sensors method calculate structural deformation distribution measured long gauge strains proposed shear deformation effect considered main girder studied bridge deep length depth ratio end middle span modal identification studied bridge using measured long gauge dynamic strains also performed strain displacement mode shapes identified results demonstrate superiority long gauge fiber optic sensors successful application studied bridge american society civil engineers
little known mechanisms smartphone features used sealing relationships psychopathology problematic smartphone use purpose investigate two specific smartphone usage types process use social use associations depression anxiety accounting relationships anxiety depression problematic smartphone use social smartphone usage involves social feature engagement social networking messaging process usage involves non social feature engagement news consumption entertainment relaxation participants amazon mechanical turk intemet labor market answered questionnaires depression anxiety symptoms problematic smartphone use along process social smartphone use dimensions statistically adjusting age sex discovered association anxiety symptoms stronger process versus social smartphone use depression symptom severity negatively associated greater social smartphone use process smartphone use strongly associated problematic smartphone use finally process smartphone use accounted relationships anxiety severity problematic smartphone use elsevier ltd rights reserved
pedagogues art face serious problems comes teaching composition analysis pedagogical practice survey schoolchildren teachers art schools shows skills composition graduating institutions fine arts sufficient successful use composition creative work problem partially solved learning composition improved help subject computer graphics didactic method learning allows use several techniques learning activate composition study process construction model learning process stages applying computer graphics contributes cognitive process composition learning computer graphics activated learning steps capture consciousness use research authir developed tested tasks computer graphics elements composition rsearch indicates teaching composition improves development tasks used lessons computer graphics
objective pervasive weight stigma discrimination led ongoing calls efforts reduce bias despite increasing research stigma reduction strategies perspectives individuals experienced weight stigma rarely included inform research present study conducted systematic examination women high body weight assess perspectives broad range strategies reduce weight based stigma methods women overweight obesity completed online survey evaluated importance feasibility potential impact stigma reduction strategies diverse settings participants reported experiencing weight stigma also completed self report measures assessing experienced internalized weight stigma results participants assigned high importance stigma reduction strategies school based healthcare approaches accruing highest ratings adding weight stigma existing anti harassment workplace training rated impactful feasible strategy family environment viewed important intervention target regardless participants experienced internalized stigma conclusion findings underscore importance including people stigmatized identities stigma reduction research insights provide necessary valuable contribution inform ways reduce weight based inequities prioritize efforts
study role melanopsin expressing retinal ganglion cells mrgcs glaucoma induced depressive behavioral response pattern investigated cfp transgenic glaucoma animal model five age groups used study immunohistochemical labeling quantitative analysis mrgc morphology open field test oft statistical analysis used comparison mice age matched cfp mice significantly elevated intraocular pressure iop observed parallel morphological changes retina including reduction density cyan fluorescent protein cfp expressing cells cells months age months mrgcs months months brnb expressing rgcs months months brn expressing mrgcs months months reduction dendritic field size mrgcs months months cfp mice hyperactive locomotor activity patterns based oft findings total distance traveled number entries center time spent center testing apparatus glaucoma induced hyperactive response pattern could associated dysfunctional mrgcs likely brn positive mrgcs cfp mice
backgroundstigma associated many negative health outcomes research examined perceived internalized stigma individuals irritable bowel syndrome ibs inflammatory bowel disease ibd less done evaluate levels enacted stigma associated conditions aim study evaluate presence enacted stigma toward ibs ibd general population compared adult onset asthma aoa control group methodsparticipants recruited via social media research dedicated website completed measures online participants randomized one six clinical vignettes ibd male ibd female iii ibs male ibs female aoa male aoa female participants read assigned vignette completed measures emotional empathy level familiarity enacted stigma key resultsparticipants reported higher levels enacted stigma toward ibs compared ibd aoa differences stigma found ibd aoa higher levels familiarity strongly correlated reduced ibd related stigma weaker still significant correlations level familiarity ibs aoa higher levels emotional empathy associated reduced stigma ibd ibs aoa conclusions inferencesindividuals ibs experience greater levels enacted stigma compared ibd aoa finding consistent previous research shown greater levels perceived internalized stigma ibs compared ibd
background allergic diseases thought inherited prevalence allergic diseases however increased dramatically last decades suggesting environmental causes development allergic diseases objective studied risk factors associated development atopic dermatitis allergic rhinitis asthma children non atopic parents subtropical country methods birth cohort newborns parents prenatally enrolled validated allergic diseases questionnaire physician verified total specific immunoglobulin ige levels children respectively completed year year follow clinical examination questionnaire blood samples total specific ige children collected follow visit results prevalence respectively children non atopic parents prevalence significantly higher children parents atopic combination cesarean section breastfeeding month showed highest risk infants living homes curtains air filters highest risk male infants non atopic parents living homes without air filters highest risk conclusions breastfeeding affect development gender use curtains air filters affect suggesting control perinatal environment necessary prevention atopic diseases children nonatopic parents
background calorie restriction influences aging processes extends average maximal life spans calerie comprehensive assessment long term effects reducing intake energy phase study first randomized clinical trial examine metabolic psychological effects nonobese humans objective conducted follow study adults underwent libitum control consumption determined whether weight loss acquired behaviors persisted study ended participants determined lifestyle behaviors design prospective longitudinal study assessed differences weight body composition psychological function energy expenditure nonobese body mass index men women control completed calerie study pennington biomedical results participants follow study subjects control completed visits follow months intervention mean sem weight loss observed group weight regained later despite regain weight percentage body fat fat mass remained significantly reduced baseline throughout follow remained significantly less control group follow group retained higher degrees dietary restraint avoidance certain foods conclusion intensive intervention similar induced weight loss maintained later probably result lasting effects acquired behaviors dietary restraint
crop production district kasaragod kerala state india characterized low input low yield concept rain fed agriculture field study conducted western ghat region district develop suitable rainwater harvesting system adoptable hilly terrains test efficacy improving use efficiency harvested water multiple uses cost benefit analysis water harvesting system also carried find affordability farmers water harvesting system developed integrating three components improving productivity coconut component crops cropping units developing multiple water use systems iii conjunctive use harvested water along surface groundwater resources based estimated annual costs returns benefit cost ratio found financial viability criteria irr npv also found favourable investment lined water harvesting tank integrated micro irrigation system fish farming study suggested rainwater harvesting could implemented viable alternative conventional water supply farm irrigation projects considering fact land anywhere used harvest rainwater water use efficiency improved effective harvesting subsequent multiple uses stored water
continuum mechanics based approximation often unsatisfactory solution real material problems especially experimental well computational fatigue applications various methods classical deterministic analyses often produce inconclusive conflicting estimates fatigue life component addition classical griffith irwin orowan concept assumed phenomena based homeomorphism mathematics developed closer experimental results anymore already reached saturation point note discusses fundamental reasons limitations classical fracture mechanics subsequently predicts alternatives application classical fracture mechanics engineering problems discussed along possible alternatives employing probabilistic fractal fracture mechanics materials engineering elsevier rights reserved
objectivesconversion rates trial leads permanent spinal cord stimulation scs systems important implications healthcare resource utilization hcru pain management hypothesized volume outcome effect chronic pain patients visit high volume scs implanters higher trial permanent conversion rates materials methodswe designed large retrospective analysis using truven marketscan database analyzing adult scs patients provider information available without ipg implantation years designed patients divided three provider based groups high medium low volume providers univariate multivariate models identified factors associated successful conversion resultsa total unique trial implants performed providers patients baseline data available progressed permanent scs higher volume providers associated slightly higher conversion rates low volume explant rates medium volume younger age years years medicare medicaid low volume southern region low volume higher charlson comorbidity scores multivariate regression results showed female gender high volume providers associated higher odds successful trial conversion conclusionsin nationwide analysis high volume providers achieved higher trial permanent scs conversion rates lower volume providers study implications training requirements referral patterns delineate minimum implant experience necessary provider proficiency future studies may useful understand hcru differences
research monoracial college students experiences racial microaggressions increases minimal research focuses multiracial college students experiences racial microaggressions manuscript addresses gap literature focusing multiracial college students experiences multiracial microaggressions type racial microaggression utilizing qualitative data study explored different multiracial microaggressions multiracial women experienced historically white institution including denial multiracial reality assumption monoracial identity monoracial enough fit
present study lead free solders used electronics packaging industry reinforced different volume percentages nano size alumina tin oxide particulates respectively synthesize two new sets nanocomposites composites developed using microwave assisted powder metallurgy route followed extrusion effects addition particulates physical microstructural mechanical properties nanocomposites investigated mechanical properties microhardness uts composite systems increase presence particulates best tensile strength realized composite solders reinforced vol alumina vol tin oxide particulates far exceeds strength eutectic solder morphology pores observed one dominating factors affecting strength materials
objective antisocial personality disorder aspd schizophrenia well childhood abuse associated violent behaviour show marked volumetric reduction anterior cingulate brain region implicated regulation violence involvement decision making empathy impulse control emotion regulation present study examined first time authors knowledge grey matter volume relation seriously violent behaviour childhood psychosocial deprivation including physical sexual abuse context mental disorder schizophrenia aspd methods fifty seven men aspd history serious violence schizophrenia history serious violence vsz schizophrenia without violence history nonviolent healthy participants underwent whole brain magnetic resonance imaging rated presence physical abuse sexual abuse neglect extreme poverty foster home placement criminal parent severe family conflict broken home collectively psychosocial deprivation stereological volumetric ratings examined group differences association childhood psychosocial deprivation results higher proportion aspd vsz patients suffered psychosocial deprivation children particular severe physical abuse relative patients healthy participants aspd vsz patients significantly lower volume relative healthy participants volumes correlated negatively total psychosocial deprivation well physical sexual abuse ratings group differences volume became nonsignificant psychosocial deprivation ratings covaried conclusions violent mentally disordered individuals aspd schizophrenia suffer significant volume loss deficit least part explained histories stressful childhood experiences current future therapies aiming reduce violence populations would benefit attending biological correlates childhood abuse
assessing effect new freshman electrical engineering course sequence follow courses one assessments survey distributed sophomores electrical circuits juniors microelectronics courses roughly one half freshman year spent programming matlab problem solving using programming tools observation students consider programming important reasonably good confidence self efficacy solve problems using matlab however asked frequency use tools students report using somewhere week month significant number students report almost usage results consistent across sophomore junior years slight tick frequency use juniors hypothesizing students view matlab tools problem solving yet another item acquire studies plan change instruction sophomore courses problem solving requires programming introduced existing survey used measure future improvement
recent years increased concerns pollution greenhouse gas emissions initiated wave policy change governmental industry non governmental organisations order reduce overall environmental impact ensure sustainable future green building council instance identified construction one emission intensive industries accounting around greenhouse gas production study hybrid life cycle assessment lca technique used analyse plasterboard supply chain commonly used product construction industry one europe leading distributor contractor building materials study demonstrates emission hotspots across lifecycle products identified analysed using different intervention options supply chain attempt reduce greenhouse gas emissions plasterboard supply chain implementation cross docking principles use renewable sources energy warehousing determined major decarbonzation interventions elsevier rights reserved
attachment recently proposed key developmental construct psychosis particular respect interpersonal functioning social cognition current study examined latent structure self report psychosis attachment measure pam relationship lower level perceptual higher order inferential social cognitive processes pam administered psychiatrically stable outpatients schizophrenia alongside battery symptom social cognitive functional measures pam responses analyzed using latent variable measurement models yield evidence coherent two dimensional structure predicted previous literature unidimensional subscale comprising original pam items possessed strongest psychometric properties subscale generally uncorrelated social cognitive measures showed weak correlations symptoms measures community functioning results suggest either pam may measure attachment psychosis may measure attachment anxiety demonstrate little construct validity population results tell cautionary tale regarding making theoretical inferences basis measures without coherent latent structure attachment measures stronger psychometric properties help clarify putative relationships attachment social cognitive processes psychosis elsevier ireland ltd rights reserved
due rapid development renewable energy waste energy recovery absorption energy storage important technology promising future however researches focus working fluid flow rather energy flow used electric power systems hard analyze entire systems whole contribution introduces electrical circuit analogy analyze absorption energy storage systems perspective energy flow turns energy storage release processes corresponding electrical circuits described kirchhoff laws circuitous philosophy instead complex component analysis basis optimization absorption energy storage system converted conditional extremum problem applying lagrange multiplier method offers optimization equations directly obtain optimal structural operating parameters best performance contribution optimized results offer higher power storage release cases respectively compared existing experimental results besides inspired batteries connected parallel series design multi stage absorption energy storage system could store low grade heat provide high grade heat reveals superior newly proposed approach elsevier ltd rights reserved
widespread use smart mobile devices clinical trials online surveys offers promising perspectives respect controlled collection high quality data design implementation deployment mobile data collection applications however challenging several respects first various mobile operating systems need supported taking short release cycles vendors account well second domain specific requirements need flexibly aligned mobile application development third usability styleguides need obeyed altogether turns programming maintaining mobile applications costly time consuming error prone endeavor remedy drawbacks model driven framework empowering domain experts implement robust mobile data collection applications intuitive way realized design end user programming framework based experiences gathered real life mobile data collection projects facets various stakeholders involved projects discussed overall architecture well components presented particular shown framework enables domain experts end users flexibly implement mobile data collection applications overall framework allows effective support mobile services multitude application domains
based qualitative research elite interviews narrative analysis hungarian documents main aim article twofold elucidate transformation jobbik marginal extra parliamentary youth focused movement influential parliamentary party discuss impact jobbik ascension main centre right fidesz pre conclusion argues rise jobbik protest phenomenon simply demonstrates social disenchantment transitional economy jobbik transformation unique post communist political development rooted elements hungarian nationalism national elements include underlying social prejudice roma jews preference paternalistic economic systems even attraction historical narrative mythic turanism debate origins hungarian national identity jobbik manipulates national elements transformation party identity emerging main challenger fidesz published elsevier ltd behalf regents university california
background limited availability maternal child health data limited progress reducing mortality morbidity among pregnant women children global health agencies leaders funders prioritizing strategies focus acquiring high quality health data electronic maternal child health registries eregistries offer systematic data collection management approach serve entry point preventive curative promotive health services due highly sensitive nature reproductive health information careful consideration must accorded privacy access data security third paper eregistries series report current landscape ethical legal governance maternal child health registries developing countries methods research utilizes findings two web based surveys completed targeted public health officials health care providers countries high global maternal child mortality burden sample public health officials countries health care providers countries completed online survey based formative research development eregistries governance guidance toolkit surveys designed investigate topics related maternal child health registries including ethical legal issues results according survey respondents prevailing legal landscape characterized inadequate data security safeguards weak support core privacy principles respondents majority countries indicated health information medical records typically protected legislation although legislation dealing specifically comprehensively data privacy may place health care provider trust privacy health data facilities associated presence security safeguards conclusion addressing legal requirements ensuring privacy data security women children health information protected ethical responsibility must ignored postponed particularly need greatest potential harm unintended consequences inaction serious individuals could impact public trust health registries leading decreased participation compromised data integrity
performed new coupled circuit numerical simulation eddy currents open compact magnetic resonance imaging mri system following coupled circuit approach conducting structures divided subdomains along length width thickness implementing coupled circuit concepts simulated transient responses eddy currents subdomains different locations implemented eigen matrix technique solve network coupled differential equations speed simulation program hand compute coupling relations biplanar gradient coil conducting structure implemented solid angle form ampere law also calculated solid angle three dimensions compute inductive couplings subdomain conducting structures details temporal spatial distribution eddy currents implemented secondary magnetic field calculation biot savart law desktop computer programming platform wolfram mathematica processor intel core duo ghz windows professional memory ram took less min simulate entire calculation eddy currents fields approximately min gradient coil results given time space domain direct cross terms eddy current magnetic fields generated gradient coil also conducted free induction decay fid experiments eddy fields using nuclear magnetic resonance nmr probe verify simulation results simulation results found good agreement experimental results study also conducted simulations transient spatial responses secondary magnetic field induced gradient coil approach fast much less computational complexity conventional electromagnetic numerical simulation methods elsevier inc rights reserved
background thyroid dysfunction common radiotherapy patients head neck cancers attempted discover dose parameters correspond induced thyroid dysfunction methods records patients received reviewed respect thyroid function abnormalities grouped ways none transient permanent overt subclinical results median follow months incidence thyroid abnormality women men permanent dysfunction seen higher incidence women versus men permanent abnormalities strongly correlated also correlated thyroid dysfunction post concurrent chemotherapy increased permanent dysfunction conclusion achieving mean dose planning may decrease incidence whereas female sex concurrent chemotherapy seem increase risk induced hypothyroidism wiley periodicals inc
many recent software engineering papers examined duplicate issue reports thus far duplicate reports considered hindrance developers drain resources result prior research area focuses proposing automated approaches accurately identify duplicate reports however exists studies attempt quantify actual effort spent identifying duplicate issue reports paper empirically examine effort needed manually identifying duplicate reports four open source projects firefox seamonkey bugzilla eclipse platform results show duplicate reports identified within half day duplicate reports identified without discussion involvement people classification model built using set factors extracted duplicate issue reports classifies duplicates according effort needed identify precision recall roc area iii factors capture developer awareness duplicate issue peers duplicates issue textual similarity new report prior reports influential factors models findings highlight need effort aware evaluation approaches identify duplicate issue reports since identification considerable amount duplicate reports appear relatively trivial task developers better assist developers research identifying duplicate issue reports put greater emphasis assisting developers identifying effort consuming duplicate issues
background aims wheat amylase trypsin inhibitors atis nutritional activators innate immunity via activation toll like receptor tlr myeloid cells aimed characterize biologic activity atis various foods effect intestinal inflammation methods selected different gluten containing gluten free products either unprocessed wheat rye barley quinoa amaranth soya lentils rice processed pizza pasta bread biscuits atis extracted biological activities determined tlr responsive mouse human cell lines effects oral atis intestinal inflammation determined healthy cbl mice gluten free ati free diet mice given low level polyinosinic polycytidylic acid dextran sodium sulfate induce colitis parameters innate adaptive immune activation determined duodenum ileum colon mesenteric lymph nodes results modern gluten containing staples levels tlr activating atis much fold higher gluten free foods processed baked foods retained ati bioactivity older wheat variants emmer einkorn lower bioactivity modern hexaploid wheat ati species prevalent activators tlr modern wheat highly resistant intestinal proteolysis ingestion induced modest intestinal myeloid cell infiltration activation release inflammatory mediators mostly colon ileum duodenum dendritic cells became prominently activated mesenteric lymph nodes concentrations atis found normal daily gluten containing diet increased low level intestinal inflammation conclusions gluten containing cereals far highest concentrations atis activate tlr orally ingested atis largely resistant proteases heat increase intestinal inflammation activating gut mesenteric lymph node myeloid cells
paper concerned analyzing data experimental antipodal laser based chaos shift keying communication system binary messages embedded chaotically behaving laser wave transmitted fiberoptic cable decoded receiver using second laser synchronized emitter laser instrumentation experimental system makes particularly interesting able empirically analyze optical noise synchronization error well bit error rate noise error found significantly depart distribution independent gaussian conclusion bit error rate results antipodal laser chaos shift keying system offer feasible approach optical communication non gaussian optical noise synchronous error results challenge current theoretical modeling
background despite concerns rising treatment psychiatric patients psychotropic medications declining treatment psychotherapy actual treatment profiles psychiatric patients largely unknown aims describe patterns treatment patients large psychiatric university hospital department methods descriptive mapping treatment outpatients psychiatric department aarhus university hospital risskov denmark information collected healthcare staff using item survey form value calculated chi squared test considered significant study preceded pilot study patients results month period total consecutive patients assessed hereof included age range years mean men women one hundred eighty eight patients used psychotropic medication monotherapy combination non pharmacological therapy ninety seven psychotherapy social support among inpatients physical therapy electroconvulsive therapy total non pharmacological therapy fifty two patients monotherapy polytherapy mean number treatment modalities used per patient patients inpatients conclusions department polytherapy including non pharmacological modalities applied widely across settings patient categories however psychotropic medication clearly dominates frequently applied treatment
inconclusive results reported studies investigating association brain derived neurotrophic factor bdnf polymorphism migraine present study conducted systematic review meta analysis published data order quantitatively estimate relationship migraine susceptibility comprehensive search performed pubmed web knowledge cochrane databases october pooled odds ratio corresponding confidence interval calculated estimate strength association additive dominant recessive model inheritance total five studies including cases controls identified meta analysis pooled data showed increased risk migraine allelic dominant model statistical significance lost one single study excluded analysis dominant allelic suggesting lack robustness pooled estimates stratified migraine type similar trend association detected statistically significant association reached subtype dominant model present meta analysis supports bdnf may act genetic susceptibility factor migraine nevertheless large scale studies required confirm findings assess potential modifiers relationship migraine
web based learning framework electrical discharge machining edm presented research architecture supports hands exercise precision manufacturing field distance education allows learners practice access edm based virtual environment means internet meanwhile learning website planned constructed order facilitate interactivity support edm research open source software tools virtual interactive technology available integrated develop emulated effective learning environment distance education learning architecture built independently specific hardware software edm configuration paper concludes example implementation phase learning prototype environment
two studies examine need cognitive closure nfc referring individual tendency reduce uncertainty via rigid processing style relates way attentional resources distributed multitasking previous studies show nfc related focused rather distributed attention high nfc individuals thus process tasks serially rather parallel order maintain performance additional task would need shift attentional focus task often low nfc individuals hand able process tasks parallel would maintain performance additional task fewer attentional shifts test hypotheses asked participants perform main additional task simultaneously task performance participants eyes tracked line predictions interest area analysis showed nfc related fixations longer dwell time additional task also associated runs task studies effects stronger difficult compared easy condition study paper first one directly test attention allocation multitasking depending nfc levels elsevier ltd rights reserved
inflammatory bowel disease ibd includes crohn disease ulcerative colitis associated increased prevalence osteoporosis osteopenia aim evaluate use world health organization fracture risk assessment frax tool patients assess risk fracture electronic searches performed key words relating ibd frax medline embase scopus databases summary estimates calculated fixed random effects model used depending heterogeneity search yielded references included research carried adult patients used systematic review quantitative summary significant publication bias noted according harbord test probability hip major osteoporotic fracture adult ibd patients confidence interval respectively patients crohn disease hip major osteoporotic fractures calculated frax increased respectively risks fracture adults ulcerative colitis provided single study frax tool limitedly used patients ibd however evidence currently available shows modest increase risks bone fracture support unequivocally need specific interventions well designed studies needed confirm results obtained systematic review
results reconfigurable pifa using smart materials presented novel approach investigated using pzt materials switch contact using control voltage reconfigure pifa structure hence produce tunable antenna
negative geotaxis climbing assay used efficiently study aging neurodegeneration drosophila make suitable large scale study method called rapid iterative negative geotaxis ring assay established simultaneously photographing climbing multiple groups flies manually tapped test tubes automated assay using well controlled electric motor drive tapping homemade program analyze climbing height flies using automated ring aring assay found climbing ability strain wild type flies males particular declined rapidly day eclosion slowly day also found expression arctic mutant beta accelerated age dependent decline climbing ability flies moreover using aring examined effect third chromosome deficiencies accelerated locomotor decline beta expressing flies isolated suppressors enhancers
background eating disorders lethal heritable however underlying genetic factors unknown binge eating highly heritable trait associated eating disorders comorbid mood substance use disorders therefore understanding genetic basis inform therapeutic development could improve several comorbid neuropsychiatric conditions methods assessed binge eating closely related cbl mouse substrains cross identify quantitative trait loci associated binge eating used gene targeting validate candidate genetic factors finally used transcriptome analysis striatum via messenger rna sequencing identify premorbid transcriptome binge induced transcriptome inform molecular mechanisms mediating binge eating susceptibility establishment results cbl cbl mice showed rapid robust escalation palatable food consumption mapped single genome wide significant quantitative trait locus chromosome logarithm odds missense mutation cytoplasmic fmr interacting protein cyfip validated cyfip major genetic factor underlying binge eating heterozygous knockout mice cbl background showed reduced binge eating toward wild type cbl like level transcriptome analysis premorbid genetic risk identified enrichment terms morphine addiction retrograde endocannabinoid signaling whereas binge eating resulted downregulation gene set enriched decreased myelination oligodendrocyte differentiation expression conclusions identified cyfip major significant genetic factor underlying binge eating provide behavioral paradigm future genome wide association studies populations increased genetic complexity
solar thermal fuels stfs harvest store solar energy closed cycle system conformational change molecules release energy form heat demand aim developing tunable optimized stfs solid state applications designed three azobenzene derivatives functionalized bulky aromatic groups phenyl biphenyl tert butyl phenyl groups contrast pristine azobenzene crystallizes makes nonuniform films bulky azobenzene derivatives formed uniform amorphous films charged discharged light heat many cycles thermal stability films critical metric thermally triggerable stfs greatly increased bulky functionalization degrees able achieve record high energy density solid state stfs improvement compared previous solid state reports furthermore chargeability solid state improved charged charged previous solid state reports results point toward molecular engineering effective method increase energy storage stfs improve chargeability improve thermal stability thin film
impact depression quality life qol social support neither well characterized clinical samples women perimenopausal depression pmd relative contributions depression menopausal symptoms hot flushes declining qol clarified study compared qol measures social support functional disability pmd non depressed perimenopausal women evaluated women aged years presented menstrual cycle irregularity elevated plasma fsh levels met criteria perimenopause structured clinical interview administered determine presence absence major minor depression outcome measures included quality life enjoyment scale questionnaire sheehan disability scale global assessment functioning social adjustment scale duke social support index kruskal wallis tests anovas used compare outcome measures ninety women pmd control women participated study women pmd reported significantly decreased qol social support adjustment increased disability compared non depressed perimenopausal women neither perimenopausal reproductive status alone presence hot flushes significant negative impact qol measures pmd accompanied significant reductions qol social support disability similar depression women stages life pmd may also contribute decreased qol community clinic based samples perimenopausal women remains unclear whether clinical characteristics identified reflect pre existing risk factors depression perimenopause effects current depression future clinical treatment studies perimenopausal women distinguish depressed women outcome measures include qol
agriculture recognized major anthropogenic source surplus loads nitrogen environment losses nitrate via subsurface pathways severely threatening groundwater surface waters study explored capability coupled hydro biogeochemical spatially explicit model simulating nitrogen cycling agricultural soils associated fate excess nitrate subjected vertical lateral displacement towards water bodies different vegetated buffer strips vbs tested nitrate retention capability impacts emissions effectiveness vbs remove nitrate denitrification strongly depends soil characteristics hydrological flow paths simulated emissions vbs high soil moisture twenty fold compared vbs groundwater levels low simulated sneamwater nitrate concentrations without vbs showed decrease vbs elsevier ltd rights reserved
porous media combustion pmc relatively new concept due inherent characteristics high efficiency low emissions found wide applications many practical systems like internal combustion engine engine water heater lpg liquefied petroleum gas stoves etc study concept pmc employed kerosene pressure stove usefulness media consisting alumina alo silicon carbide sic terms efficiency emissions investigated conditions optimum efficiency emission brought systematic analysis different burner geometry exergy calculation major highlight study highest efficiency stove porous media found similar higher average thermal efficiencies stoves available indian market elsevier ltd rights reserved
century researchers used enculturated animals extensively trained reared humans explore effects learning environment capacities linguistic abilities outside human line unfortunately due many controversies findings studies frequently dismissed outright ignored however experimental exploration capacities nonhumans option determine language associated capacities unique humans researchers continue publish findings language projects move understanding forward including descriptions capacities gestural comprehension declarative communication categorization frequently considered specific biological adaptations
weanling pigs underdeveloped intestine immature immune system usually subjected depressed feed intake growth retardation postweaning diarrhea aim study determine growth response weaned pigs supplemental tributyrin potential effects mechanisms modulating immune responses lipopolysaccharide lps challenged piglets total piglets duroc large white landrace weaned age control basal diet supplemented antibiotics supplemented supplemental diets replicate pens piglets pen per diet age male pigs control groups intraperitoneally injected lps saline sacrificed injection collect blood intestine digesta samples biochemical analysis higher feed intake lower percentage negative growth pig lets groups control group first week weaning piglets without lps challenge higher ileal fibroblast growth factor fgf mrna abundance total bile acid concentrations groups control group whereas downregulated fgf expression observed groups lps challenge lipopolysaccharide challenge control group increased plasma tumor necrosis factor concentrations colonic escherichia coli amount decreased observed groups following lps challenge taken together dietary supplementation prevented growth retardation stimulating appetite weaned pigs protected piglets lethal infection via modulation inflammatory cytokines production ileal fgf expression intestinal acetate fermentation
paper wind electrical power generation system distributed site dos applications proposed system developed conceived order guarantee simple installation use service obtaining product easily industrialized put market limited costs field application electrical generation system addressed towards domestic toward condominium applications concerning moreover opportunity working addition combined photovoltaic solar thermal systems enhance renewable energy generation house level dos proposed system hot spot blades shape wind flux canalization system permanent magnet synchronous generator pmsg optimized specific purpose fact proposed system intends search best aerodynamic profile electrical generator ensure slightest encumbrance lowest weight purpose traditional classical tangential wind turbine design equipped large blades overturned favour use numerous little blades peculiarity system expected increase efficiency thanks presence wind flux channelling system elimination part opposing wind thanks adoption specifically designed pmsg
designing implementing agri environmental policies reduce nutrient loss action programmes may falsely address areas nutrient issue agricultural activity currently important likely become future false positive may fail address areas agricultural nutrient issue currently important may likely become future false negative based case study louros watershed greece work identifies database modelling sources false positives negatives proposes decision making process aimed minimizing possibility committing errors baseline well simulated shows louro watershed falls behind good environmental status least marginally simulated mitigation measures show river status upgraded good least concerns nitrates ammonium simulated climate change seem exert important positive negative effect land use changes forecasting considerably less cultivated area significant effect total phosphorous nitrates ammonium concentrations non linearity nutrient disposition inputs nutrient concentration downstream water bodies output many factors affect nutrient disposition transportation concentration chain highlights importance simulating effects mitigation actions future climate land use changes adopting establishing agri environmental measures elsevier rights reserved
backgroundautism spectrum disorder asd neurodevelopmental disorder social communication deficits one core symptoms recently five level model social communication proposed white matter tracts corresponding level model identified given model social communication subserves social language functions hypothesized tract integrity model social communication may reduced asd reduction may related social communication deficits methodssixty two right handed boys asd typically developing boys received clinical evaluations intelligence tests social communication questionnaire scq mri scans generalized fractional anisotropy gfa measured diffusion spectrum imaging indicate microstructural integrity tracts level social communication model group difference tract integrity relationship scq subscales social communication social interaction investigated resultswe found gfa values superior longitudinal fasciculus iii slf iii level frontal aslant tracts fat level decreased asd compared moreover gfa values slf iii fat associated social interaction subscale asd conclusionsthe tract integrity model social communication reduced asd reduction associated impaired social interaction results support reduced tract integrity model social communication might neural substrate social communication deficits asd
smart farming management style includes smart monitoring planning control agricultural processes management style requires use wide variety software hardware systems multiple vendors adoption smart farming hampered poor interoperability data exchange ict components hindering integration software ecosystems recent emerging concept software engineering addresses integration challenges currently several software ecosystems farming emerging guide accelerate developments paper provides reference architecture farm software ecosystems reference architecture used map assess design implement farm software ecosystems key feature architecture particular configuration approach connect ict components developed multiple vendors meaningful feasible coherent way reference architecture evaluated verification design requirements mapping two existing farm software ecosystems using farm software ecosystem reference architecture mapping showed reference architecture provides insight farm software ecosystems describe similarities differences main conclusion two existing farm software ecosystems cad improve configuration different ict components future research needed enhance configuration farm software ecosystems authors published elsevier
iron loss modeling crucial electric machine design however current models feature severe drawbacks complex thus hardly applied require high effort measuring computation accurate paper newmodeling technique introduced calculating instantaneous power loss ferromagnetic materials without taking magnetization history account standard measurement setup specimen shape used considered approach comprises required measurements nonlinear loss modeling extensive verification different flux density waveforms frequencies addition detailed qualitative comparison well known iron loss models given presented technique gives accurate results obtaining model comparably easy moreover calculation instantaneous losses based previous magnetization state material modeling error particular instant time impact subsequently calculated characteristics future model ensure accurate iron loss calculation electric machine designs
pharmaceutical opioid use harms increasing dramatically treatment related stigma may present treatment barrier people use additionally differences social support opioid treatment populations may positively influence treatment outcomes scoping methodology utilised map current knowledge searches performed medline psycinfo embase eligibility criteria required articles related stigma social support treatment use search identified relevant articles stigma themes included individual perceptions opioid dependence community perceptions opioid dependence blame stigmatising factor language surrounding opioid use treatment experience social support themes included family support web based support friends support partners support social network therapy limited literature found focussing specifically stigma social support people use highlighting important area future work
objective one avenue intense efforts treat parkinson disease involves delivery neurotrophic factors restore dopaminergic cell function source neurotrophic factors could used schwann cell peripheral nervous system authors begun open label safety study examine safety feasibility implanting autologous peripheral nerve graft substantia nigra patients undergoing deep brain stimulation dbs surgery methods multistage dbs surgery targeting subthalamic nucleus performed using standard procedures study participants dbs leads implanted section sural nerve containing schwann cells excised unilaterally delivered area substantia nigra adverse events continuously monitored results eight participants implanted dbs systems grafts adverse event profiles comparable standard dbs surgery postoperative images reveal edema hemorrhage significant signal changes graft target region three participants reported patch numbness outside foot sural nerve harvest site conclusions based safety outcome procedure targeted peripheral nerve graft delivery substantia nigra time dbs surgery feasible may provide means deliver neurorestorative therapy
discuss dynamics inextensible thin kirchhoff rod used modeling surgical threads demonstrate efficient scheme simulate motion thread real time per frame also obtain constraint axial forces fed back haptic system numerical scheme based family schemes called geometric discrete variational integrators guaranteeing momentum energy exactly conserved long periods time conservative systems besides report efficient numerical procedure handle inextensibility thread physically based lagrange multipliers well internal dissipation thread performed simulations verify capabilities model conserve momentum energy accurately calculate axial constraint forces along thread haptic feedback capture bending torsion coupling leading formation plectonemes many ideas well known computer graphics community especially hair modeling implemented several improvements specific purpose speeding computations developing physically based haptic interfaces knot tying suturing elsevier ltd rights reserved
blend growing amounts power renewable resources utility operations requires accurate forecasts day ahead planning real time operations power wind solar resources must predicted based real time observations series models span temporal spatial scales problem using physical dynamical knowledge well computational intelligence accurate prediction big data problem requires disparate data multiple models applicable specific time frame application computational intelligence techniques successfully blend model observational information real time deliver decision makers utilities grid operators paper describes example system used utility applications configured meet utility needs addressing big data issues
objective despite concerns exposure violent media data youth exposure violent movies study examined exposure among young adolescents methods used random digit dial survey adolescents aged years fielded using previously validated methods determined percentage number adolescents seen recently released movies report results rated violence motion picture association america british board film classification coded extreme violence trained content coders results violent movies seen median estimated million adolescents aged years popular violent movie scary movie seen million children million years age watching extremely violent movies associated male older nonwhite less educated parents poorly school black male adolescents particularly high risk seeing movies example blade training day scary movie seen respectively sample overall versus black male adolescents violent movie exposure also associated measures media parenting high exposure adolescents significantly likely television bedroom report parents allowed watch rated movies conclusions study documents widespread exposure young adolescents movies extreme graphic violence movies rated violence raises important questions effectiveness current movie rating system
context problem identifying thereafter representing analyzing managing information knowledge organization always crucial achieve business goals efficient flexible way particularly plm context issue information overload growing importance emergent challenge consists providing context driven access federated information knowledge fostering cross discipline collaborations actors improve quality product development paper highlights key issues knowledge definition representation propose bottom approach based user story mapping method usm method user centric leads definition current expected scenarios processes along collaboratively agreed vision common concepts viewpoints therefore derived generalized process merging defined roles activities usages sequences focus product content bottom approach provides federated common understanding information throughout industrial product process lifecycle combined appropriate tools methods questionnaires standards specifications knowledge based approaches etc results definition knowledge network domain therefore improves capabilities sharing reusing knowledge collaborative product development proposed approach applied context european project linkeddesign linked knowledge manufacturing engineering design next generation production based three application scenarios
paper reviews recent developments power loss analysis applicable limited thermal design electrical machines accurate computationally efficient loss prediction essential element thermal analysis electrical machines become increasingly important part machine design development process continuous drive towards electric technologies resulted need comprehensive detailed design approach various multi physics multi disciplinary effects accounted design application methodology relies strongly advancements evolution existing theoretical experimental design techniques satisfy evermore demanding machine design requirements thermal behaviour efficiency power conversion machine performance measures essential elements design application approach overview challenges limitations regarding power loss analysis context thermal design electrical machines provided paper major loss components associated active parts machine assembly discussed
background budd chiari syndrome bcs characterized obstruction blood flow hepatic veins aim study analyze diagnosis etiology management bcs methods analyzed patients females males mean age age treated tips ascites found patients frequent symptom median total follow months non covered bare covered stent inserted patients diagnosis myeloproliferative neoplasm mpn based criteria inherited acquired thrombophilia assessed well therapy bcs regard etiology results etiology bcs identified cases mpn found common risk factor especially polycythemia vera jakvf mutation detected mpn cases second common etiologic factor inherited thrombophilia non covered bare stent group primary patency rates year years tips portasystemic shunt transjugular intrahepatic creation covered stent group year year primary patency rates respectively average year intervention rate per patient procedures bare stent group covered stent group interventions frequent mpn patients patients anticoagulated heparin beginning switched vitamin antagonist top tips anticoagulant vigorous therapy underlying disorder necessary conclusion bcs serious life threatening disorder mpd major cause morbidity mortality therapy requires multidisciplinary approach insertion tips dedicated covered stent effective treatment cases resistant conservative approach lower dysfunction rate number interventions
recent years along rapid development industrial technology development spark erosion technique becomes important plays key role molding processing technology especially situation technology urgently needed based first hand data production site introduced regarding structure working principle hcdk spark erosion machine tool time common faults problems pulse power servo feed system analyzed details proposed solution detailed analysis also given problems like frequent poor discharge reasons diagnosis methods deeply studied well helpful supportive providing evidence minimizing machine design defects making continuous improvement design paper meaningful helping machine tooling design step higher level spark erosion machine tooling improving continuously
ruxolitinib jak jak inhibitor tested approved treatment primary secondary myelofibrosis aim study report safety efficacy ruxolitinib patients affected treated outside clinical trials collected treated consecutively lazio cooperative group negative myeloproliferative diseases males females median age years range forty five patients diagnosed primary secondary seventy seven patients experienced constitutional symptoms baseline patients tested jak mutated overall patients received hydroxyurea firstline treatment patients received chemotherapeutic approaches whereas treated ruxolitinib frontline median time diagnosis start ruxolitinib whole cohort months fifty eight patients required dose reduction first months due hematological toxicity majority cases weeks patients obtained clinical benefit patients patients patients spleen response overall patients disappearance baseline symptoms burden year evaluable patients achieved maintained clinical benefit adverse events special interest grade included anemia thrombocytopenia infections bronchopneumonia fluid retention diarrhea abdominal pain median follow months start ruxolitinib median daily dose decreased bid patients discontinued drug results retrospective multicentric analysis confirmed efficacy ruxolitinib outside clinical trials half treated patients achieving maintaining clinical benefit reporting relief symptoms
individuals family history substance use disorders greater risk developing substance use disorders peers family histories vulnerability proportional number affected relatives density risk developing substance use disorders peaks adolescence early adulthood general population thought related delayed maturation frontocortical frontostriatal functional circuits hypothesized youth young adults impaired myelination frontocortical frontostriatal white matter tracts examined fractional anisotropy data youths years young adults years youths lower values frontocortical frontostriatal tracts well parietocortical tracts including anterior superior posterior corona radiata superior frontal occipital fasciculus moreover values tracts negatively correlated density adults lower values two frontocortical tracts genu corpus callosum anterior corona radiata also significant negative correlations density tracts groups lower values corresponded higher radial diffusivity suggesting reduced axonal myelination interpreted findings evidence impaired myelination frontal white matter proportional density data suggest deficits may partially resolve age paralleling age related decline risk developing substance use disorders hum brain mapp wiley periodicals inc
air pollution become major social problem motor applied traction system traction motor operates wide operation range paper concentrated winding ipmsm presented existing model high speed harmonics motor becomes large becomes problem control side therefore designing vehicle electric motor necessary design motor order reduce load back electromotive force coasting harmonics high speed winding method tendency permanent magnet study improvement satisfy constraints harmonics high speed back electromotive force coasting existing model need improve design satisfy output characteristic get design parameters tendency analysis design final model using design parameters finally verify final model electromotive characteristics using fem
enhancing fidelity quantum state transmission noisy environments significant subject field quantum communication paper improving fidelity deterministic remote state preparation rsp protocol decoherence investigated technique weak measurement weak measurement reversal wmr first construct quantum circuit deterministic remote preparation single qubit state epr state assistance auxiliary qubit analytically derive average fidelity deterministic rsp protocol influence generalized amplitude damping noises acting epr state results show qubit undergoes decoherence channel average fidelity rsp protocol subject generalized amplitude damping noise subject amplitude damping noise moreover analyze optimal average fidelity rsp process introducing wmr found application ofwmand subsequent reversal operation could lead remarkable improvement average fidelity values decoherence parameters
experimental study intended examine whether integration game characteristics opensimulator supported virtual reality learning environment improve mathematical achievement elementary school students pre posttest experimental comparison study data collected fourth graders achievement test math problem solving tasks provided experimental control groups learning setting tasks experimental group involved game characteristics challenges storyline immediate rewards integration game play learning content analysis covariance achievement test results indicated significant effect game based learning gbl environment comparison non gbl environment promoting math knowledge test performance
ionic polymer metal composite abbreviated ipmc smart material consisting two layers noble metal ion conducting layer smart materials generally capable actuating sensing mechanical deformation ipmc beam produces electrical potential difference order proportional deformation ion conducting layer paper sensing capabilities ipmc samples investigated composites manufactured form thin plates cut rectangular samples aging aspect ipmc considered comparison previously used newly acquired samples study fatigue parameters sensing response researched response samples various frequencies tested sample two mechanically electrically coupled samples finally certain applications ipmc proposed based measurements elsevier rights reserved
objective sleep quality significant impact health quality life affected among factors age sex however prevalence problems area general population well known therefore objective study prevalence main characteristics sleep quality adult population sample methods subjects aged years belonging murcia spain twin registry sleep quality measured self report pittsburgh sleep quality index psqi logistic regression models used analyse results results prevalence poor sleep quality stands univariate logistic regression analyses showed women almost twice likely men confidence interval poor quality sleep age directly significantly associated low quality sleep conclusions prevalence poor sleep quality high among adults especially women direct relationship age deterioration quality sleep relationship also appears consistent women sespas published elsevier espafia
previous research demonstrated people preferentially remember reputational information emotionally incongruent expectations left open question generality effect three conflicting hypotheses proposed effect restricted information relevant reciprocal social exchange effect pronounced emotional approach avoidance relevant information effect due general tendency cognitive system attend unexpected novel information regardless emotional content varied type remembered person information across experiments stimulate expectations selected faces whose facial appearance rated pleasant disgusting experiments intelligent unintelligent experiment lawyer farmer experiment faces paired behavior descriptions violated confirmed appearance based impressions source memory association faces descriptions assessed surprise memory tests results show people willing form various social expectations based facial appearance alone support hypothesis classification faces memory test biased schema congruent guessing source memory generally enhanced information violating appearance based social expectations sum results show person memory consistently affected different kinds social expectations supporting idea mechanisms determining memory performance generalize beyond exchange relevant reputational emotional information
whey proteins due high nutritional value generally hydrolyzed reduce allergenicity used ingredients many special products infant formulae geriatric products highly energetic supplements dietetic foods foods produced prevent nutrition related diseases like food intolerances allergies aim work assess applicability innovative technologies high hydrostatic pressure hhp processes assist enzymatic hydrolysis target proteins namely whey protein concentrate wpc order modify antigenicity experiments carried verify effectiveness hhp technology accelerate whey protein hydrolysis reaction selected enzymes chymotrypsin bromelain affect protein allergenic power purpose different hhp treatments carried several pressure levels mpa untreated whey protein samples used control defined enzyme substrate ratio used experiments treatment time changed min min experimental data demonstrated high hydrostatic pressure hhp induced wpc unfolding highest value pressure applied mpa indicated higher exposure free sulfhydryl groups hhp used combination enzymatic hydrolysis degree hydrolysis increased pressure level applied also processing time results suggested even exposure hidden epitopes upon protein unfolding increased antigenicity whey proteins peptide bonds cleavage also took place hydrolysis effect could modify whey proteins antigenic sequences thus antigenic power elsevier ltd rights reserved
purpose objective multicenter cross sectional study investigate relationship nocturnal polyuria patients common lifestyle related diseases overactive bladder special attention hypertension materials methods baseline assessment patients recorded hour urinary frequency volume blood pressure heart rate days stratified groups based mean blood pressure including hypertension controllable untreated uncontrolled hypertension respectively results eligible patients urinary urgency per week nocturnal toilet visits enrolled sites japan patients complete data including hour frequency volume chart collected multivariable analyses showed statistically significant association nocturnal polyuria increasing age gender women men controllable untreated uncontrolled hypertension hypertension however assessed separately men women hypertension heart rate significantly associated nocturnal polyuria women alone respectively lower urinary tract symptoms suggestive benign prostatic hyperplasia significantly associated nocturnal polyuria men alone conclusions current study demonstrates nocturnal polyuria significantly associated age male gender untreated hypertension patients lifestyle related diseases overactive bladder association hypertension nocturnal polyuria significant women alone
present field programmable array analog digital devices fpaadd novel implementation field programmable mixed signal array fpma fpaadd hybrid combination field programmable analog array fpaa field programmable gate array fpga unlike fpmas fpga fpaa portions kept separate architecture closely integrates two fine grained interleaved array instead using hard coded data converters fpaadd synthesizes data converters reconfigurable fabric analog digital portions share common global interconnect floating gate transistors used switch memory elements chip providing better switch performance power traditional static random access memory based approaches precise programmability switches also allows computation take place interconnect key differences make fpaadd much general purpose previous fpma architectures fpaadd consists array digital analog tiles peripheral circuitry die fabricated cmos process contains transistors
individuals psychopathy often characterized emotional processing deficits recent research examined specific contexts cognitive mechanisms underlie abnormalities evidence suggests abnormal features attention fundamental emotional deficits persons psychopathy studies demonstrated neural underpinnings responsible effects use functional neuroimaging examine attention emotion interactions among incarcerated individuals evaluated psychopathic traits using hare psychopathy checklist revised pcl using task designed manipulate attention emotional features visual stimuli demonstrate effects representing implicit emotional processing explicit emotional processing attention facilitated emotional processing vigilance emotional content results confirm importance considering mechanisms attention evaluating emotional processing differences related psychopathic traits affective interpersonal features psychopathy pcl factor associated relatively lower emotion dependent augmentation activity visual processing areas implicit emotional processing antisocial lifestyle features pcl factor associated elevated activity amygdala related salience network regions explicit emotional processing psychopathic traits associated upregulation medial prefrontal cortex insula superior frontal regions isolating impact explicit attention emotional content factor related upregulation activity visual processing stream accompanied increased activity angular gyrus effects highlight important mechanisms underlying abnormal features attention emotional processing accompany psychopathic traits
preferable detect leakage status earliest phase manufacturing process assembly hydraulic components leakage faults avoided integrating usb based microcontroller pressure transducer also environmental safety considerations study developed hydraulic leakage detection system using air lower pressure operation ranges measuring pressure decay signals captured real time pressure decay data collected developed hydraulic leakage detection system hydraulic testing tube installed tight tight threading connections simulate leakage leakage treatments two different system pressure levels statistical analysis found developed prototype system capture visualize pressure decay curve real time two signals pressure drop test start end point pressure drop rate testing period used featured characteristics quickly detect hydraulic leakage components status
introduction adherence poor among patients taking antihyperglycemic agents ahas type diabetes mellitus tdm inadequate adherence linked decreased glycemic control increased healthcare costs hospitalizations examined impact real world adherence glycemic control tdm patients treated canagliflozin methods retrospective study used administrative claims data commercial medicare advantage healthcare enrollees study subjects adult tdm patients baseline hbac pharmacy claim canagliflozin april august outcomes included treatment patterns hbac reductions goal attainment pharmacy costs patient characteristics adherence measured proportion days covered pdc calculated number days canagliflozin availability divided length follow period results analyzed overall compared patients highly adherent pdc versus less highly adherent lha pdc results study population included patients end follow patients overall mean reduction hbac larger reductions hbac lha versus respectively patients achieved hbac goals respectively highly adherent patients likely achieve goals lha less highly adherent patients increased insulin use follow period patients decreased use oral ahas change insulin use conclusions patients hbac reduction months following first canagliflozin fill highly adherent patients achieved greater reduction hbac end follow period likely reach hbac goals highly adherent patients also reductions use oral ahas lha patients saw small increase insulin use
vivo challenge assay increasingly used efficacy endpoint early human clinical trials hiv prevention treatments standard methodology vivo challenge assay although use different data collection methods analytical parameters may impact results reduce comparability findings trials analysis describe impact data imputation methods kit type testing schedule tissue type variability statistical power vivo hiv growth kinetics data antigen measurements collected clinical trials candidate microbicides rectal cervical vaginal tissues challenged hiv bal vivo imputation missing data using nonlinear mixed effect model found provide improved fit compared imputation using half limit detection rectal virus growth period found earlier relatively shorter duration growth period cervical vaginal tissue types average four rectal tissue challenge assays treatment control group would needed find one log difference significant alpha larger sample size predicted needed either cervical vaginal tissue comparisons overall results indicated improvements could made design analysis vivo challenge assay provide standardized powerful assay compare efficacy microbicide products
starting theories prolong mayor influence media agency socialization criticism gender representation media work observed whether image women disney animated films changed time way change happened basic dimensions gender roles heroines placed one influential franchises named disney princesses described essay precisely animated films heroines emerging embraced analysis research close attention given activities heroines committed communications make physical appearance goals also attitude towards marriage sexuality main finding oldest heroines appeared represented accordance expectations patriarchal culture period obedient hardworking woman excluded society getting married life goal latter princesses presented highly different manner independent educated rebellious also analysis showed princesses made appearance last decade various trends appeared turned chosen road emancipation ones show indications retraditionalization
arctic river icings surface ice accumulations area thick commonly impact hydrology geomorphology ecology arctic river environments previous examination icing dynamics arctic alaska found substantial changes extent however use daily time series satellite imagery demonstrate temporal persistence minimum summertime extent large icings part arctic alaska canada declined rapidly identified large ephemeral icings disappearing significantly earlier summer mean trend day fully ephemeral features additionally icings usually persist summer significantly smaller minimum extents declines remarkably rapid suggest arctic hydroclimatic systems generating icings associated ecosystems changing rapidly plain language summary liquid water emerging groundwater flowing arctic rivers winter often freezes large ice features called river icings icings found nearly parts arctic create wide gravelly river channels important habitat animals icings melt summer help keep rivers flowing water sources limited study systematically looked whether features changing response warming temperatures use daily satellite imagery available northern alaska order test whether icings becoming smaller disappearing earlier summer features examined found either becoming smaller persist throughout summer disappearing earlier fully melt summer none becoming larger disappearing later changes may directly related warming temperatures may also happening climate change altering rivers groundwater interact trends continue may see changes form many arctic rivers impacts habitat animals like fish caribou
background combined pulmonary fibrosis emphysema cpfe increasingly acknowledged separate syndrome distinct clinical physiological radiological characteristics sought identify physiologic radiographic indices predict mortality cpfe methods data clinical characteristics pulmonary function high resolution computed tomography hrct treatment compared patients usual interstitial pneumonia uip plus emphysema cpfe group ipf alone ipf group composite physiologic index cpi hrct scores diagnosis follow assessed results cpfe group characterized predominance males smokers less likely viral infection prior diagnosis display basal crackles finger clubbing wheeze compared ipf group hrct cpi scores increased time groups moreover cpfe group poorer prognosis lower year survival rate point increase cpi score per year predictors mortality cpfe group hazard ratio confidence interval respectively conclusion patients cpfe predominantly male smokers exhibited distinct clinical physiological radiographic characteristics poorer prognosis ipf pah point increase cpi score per year predictors mortality patients future studies needed identify optimal treatment approach cpfe
caffeine adjudged world consumed pharmacologically active food component reports potential cognitive enhancing properties caffeine sought investigate caffeine influence anticholinesterase antioxidant properties donepezil selective acetylcholinesterase ache inhibitor used management alzheimer disease vitro investigated effect donepezil caffeine caf various combinations activity ache rat brain homogenate well determined antioxidant properties vivo two rat groups administered single oral dose caf separately three groups received plus either caf three hours rats sacrificed brain isolated results show caf concentration dependently synergistically increased anticholinesterase properties vitro also caf produced significant influence investigated vitro antioxidant properties furthermore rats administered caf produced significant difference ache activity compared rats administered alone however administration either caf lead higher ache activity compared control groups addition caf various combinations augmented brain antioxidant status treated rats conclude low caffeine consumption may improve antioxidant properties donepezil without significant influence anticholinesterase effect moderate high caffeine consumption could also improve antioxidant properties donepezil reduce anticholinesterase effect nevertheless comprehensive clinical trial essential fully explore possibilities human condition
purpose food allergies adverse immune reactions food despite importance studies conducted situations may cause food allergies korean children study aims obtain basic data necessary provide information food allergies patients caregivers methods study survey conducted caregivers patients years old patients situation upon occurrence food allergy examined questionnaire results approximately patients years age younger common allergens eggs milk total cases including multiple responses skin symptoms common time occurrence patients parents exposure place house followed restaurant nursery relative neighbor house exclusive unknown cases common reason exposure caregiver giving food patient reconfirmation conclusion concluded understanding food allergies based research assist management patients food allergies
study eco cultural model parenting keller cultures infancy mahwah erlbaum applied study joint attention behavior children families different socio economic status ses hypothesized infants early communication styles would differ ses reflecting independent interdependent interactions caregivers also hypothesized infants would use types behaviors whether declarative imperative communication goals early social communication scales escs mundy administered typically developing infants months approximately half siblings children autism factor analysis yielding four behavioral factors namely pointing eye contact actions following points confirmed hypothesis infants use behaviors consistently across situations independent communicative intent manovas comprising parental education income revealed higher ses infants showed actions frequently escs whereas lower ses infants followed experimenter points frequently results discussed context presumably differing socialization goals infants divergent contribution parental education income seem additive contribution factors actions following points divergent contributions others pointing eye contact elsevier inc rights reserved
design electric machines hot topic syllabuses several undergraduate graduate courses development hybrid electrical vehicles subject gaining popularity especially electrical engineering courses paper presents computer aided educational tool guide engineering students design process switched reluctance machine step step design procedure detailed user guide interface programmed matlab environment developed purpose shown user guide interface proved useful tool help students validate results obtained lecture assignments aiding achieve better understanding design process electric machines validation educational tool done means finite element method simulations
background altered balance gonadal hormones males gender identity disorders gids may increase multiple sclerosis risk inherently secondary treatment undergoing male female conversion objective investigated association gids analysis record linked hospital statistics method analysis english hospital episode statistics results adjusted rate ratio following gids males confidence interval following gids females conclusion report strong association gids male females supporting potential role low testosterone feminising hormones risk males
purpose studies humans shown acute opioid administration increases aggressive behavior laboratory study yet investigated whether opioid withdrawal produces comparable effects methods study investigated whether mild opioid deprivation affected aggression males females undergoing methadone maintenance therapy aggressive behavior measured using point subtraction aggression paradigm psap trait aggression assessed using buss perry aggression questionnaire behavior psap mood ratings profile mood states questionnaire poms measured two separate days following participant daily methadone dose order counterbalanced across participants results effects opioid withdrawal aggressive responding control response rates monetary reinforced responding self reports mood rates responding monetary reinforced option increased across sessions regardless condition suggesting exposure effect conclusion data suggest mild opioid deprivation occurring hours following methadone administration individuals undergoing methadone maintenance therapy increase aggression least individuals showing low levels aggressive behavior low measures trait aggression participants reported mood changes direct measures withdrawal possible hours methadone deprivation produced withdrawal participants remains determined whether prolonged deprivation might generate significant changes mood changes aggressive behavior
research tries include audience views media violence emphasizing active role audience vis vis media messages much like audience reception research done discourse analysis eight focus groups violence results show structuring quality reality fiction dimension viewers understanding violence also highlighted important moral component discourses moral gaze characterizes audience orientation toward media violence making orientations watch violence acceptable others considered unacceptable connection previous dimension developed around victim real violence around hero fictional violence
orthorexia nervosa described exaggerated fixation healthy food unclear whether students health oriented academic programs highly focused physical exercise prone develop orthorexia nervosa students educational areas aim compare health status physical activity frequency orthorexia nervosa university students enrolled exercise science program business program students completed short form health survey international physical activity questionnaire ipaq orto defines orthorexia nervosa sensitive obsessive behavior towards healthy nutrition showed exercise science students scored worse business students regarding bodily pain better regarding general health students orto score indicating orthorexia nervosa higher proportion exercise science students business students orthorexia nervosa combination high level physical activity often seen men exercise science studies less often women business studies high degree self reporting pain orthorexia nervosa exercise science students may cause problems future since expected coach others healthy living findings may valuable development health oriented academic programs within student healthcare services elsevier ltd rights reserved
introduction engineering technology typical first year course mechanical engineering technology curriculum many institutions course intended introduce students number aspects discipline engineering including design manufacturing engineering ethics team work areas goal motivating students engineering profession means improving instruction better engaging students learning process introduction engineering technology course wentworth institute technology paper presents series hands active learning activities deploy innovative materials techniques supported largely information technology innovative learning activities include use hands lab projects focus interdisciplinary topics leveraging internet resources video tube clips hands projects directly related subject area mechanical engineering field helps students understand feel engineering profession feedback students concerning course positive anecdotal observations indicate innovative learning activities motivated students enhanced learning experience
background medical students face ethical issues throughout lives doctors present study aims investigate medical students opinions controversial ethical issues factors associated opinions methods sbrame spirituality brazilian medical education multicenter study involving brazilian medical schools participants completed questionnaire collected information socio demographic data medical schools characteristics religious beliefs opinions controversial ethical issues participated survey results sample women mean age years general objections prescription birth control adult stem cell use embryonic stem cell use abortion genetic reasons approximately half students objections human cloning withdrawal artificial life support euthanasia abortion failed contraception socio demographic data age gender income little influence opinions hand medical schools characteristics number medical students university year medical school foundation location university type university religious aspects religious affiliation religious attendance non organizational religiousness intrinsic religiousness highly correlated opinions general supportive opinions controversial ethical issues less religious non traditional newer urban public bigger universities conclusion current study reveals different opinions regarding controversial ethical issues noteworthy opinions seem shaped university characteristics religious beliefs socio demographic data
exchanging computer aided design cad model data among heterogeneous cad systems indispensable collaborative product development currently industry mainly uses standardized neutral files based methods implement exchange time application web ontology language owl file underlying semantic web technologies cad model data exchange gaining importance popularity within academia coexistence different types methods generated series controversies questions within industry academia yet neutral files based exchange methods completely implement model data exchange among heterogeneous cad systems challenges addressed date developed cad model data exchange standards owl introduced cad model data exchange cad model data exchange really need owl issues existing neutral files based exchange methods owl file based exchange methods need addressed future studies paper proposes conduct study standardized neutral files based exchange methods owl file based exchange methods depth analysis widely used standard exchange product model data step method newly emerging owl methods first provided paper makes detailed comparison two types methods based analysis finally issues two types methods need addressed future discussed
objective disease related weight loss relatively common patients newly diagnosed multiple myeloma limited data exist regarding effects nutritional status survival aim study assess relationship malnutrition measured patient generated subjective global assessment sga clinical characteristics patients investigate association sga score chemotherapy overall survival patients methods using sga score retrospectively explored effect malnutrition survival asian patients results divided patients three groups based sga scores patients sga scores indicating severe malnutrition requiring specialist nutrition intervention body mass index serum hemoglobin independently associated sga scores multivariate analysis revealed sga scores compared sga scores hazard ratio confidence interval international staging system stage iii compared iss stage autologous stem cell transplantation associated overall survival conclusions higher sga score chemotherapy associated reduced survival among patients nutritional evaluation integral part clinical assessment patients sga score would appropriate tool evaluate nutritional status elsevier inc rights reserved
electrical properties organic field effect transistors ofets usually characterized applying models initially developed inorganic based devices often implies use approximations might inappropriate organic semiconductors approximations brought limitations understanding device physics associated organic materials strategy overcome issue establish straightforward connections macroscopic current characteristics microscopic charge transport ofets kinetic monte carlo model developed goes beyond conventional assumption zero channel thickness gradual channel approximation simulate carrier transport current using parallel computing new algorithm significantly improves evaluation electric potential within device methodology allows simulation micrometer sized ofets current characteristics representative ofet devices well reproduced provides insight validity gradual channel approximation case ofets impact channel thickness nature microscopic charge transport
background patients crohn disease frequently subjected computed tomography emergency department young population higher risk malignancy radiation exposure objectives aimed validate decision tool predicting complications perforation abscess serious finding imaging two sites methods conducted retrospective review outcomes among patients visits two tertiary care centers inclusion criteria abdomen pelvis contrast complete lab data erythrocyte sedimentation rate esr reactive protein crp within hours arrival university michigan university pittsburgh upmc sensitivity negative predictive value npv miss rate avoidance rate calculated results upmc tool sensitivity npv potentially saving miss rate tool sensitivity npv saving miss rate conclusion decision tool using crp esr predicting outcomes among patients performed well external validation allowing providers forgo use low miss rate
features extracted real world applications increase dramatically machine learning methods decrease performance given previous scenario feature reduction required particularly fault diagnosis rotating machinery number extracted features sizable order collect available information several monitored signals several approaches lead data reduction using supervised unsupervised strategies supervised ones reliable main disadvantage beforehand knowledge fault condition work proposes new unsupervised algorithm feature selection based attribute clustering rough set theory rough set theory used compute similarities features relative dependency clustering approach combines classification based distance clustering based prototype group similar features without requiring number clusters input additionally algorithm evolving property allows dynamic adjustment cluster structure clustering process even new set attributes feeds algorithm gives algorithm incremental learning property avoiding retraining process properties define main contribution significance proposed algorithm two fault diagnosis problems fault severity classification gears bearings studied test algorithm classification results show proposed algorithm able select adequate features accurate feature selection reduction approaches elsevier ltd rights reserved
purpose reviewthis review describes evolving concepts recent data relationship serum testosterone levels normal disordered sleep recent findingssex related differences circadian rhythms sleep physiology part due organizational activational effects sex steroids testosterone affects organization circadian rhythms timing duration sleep increasing testosterone puberty leads later bedtimes diurnal variation testosterone depends sleep rather circadian rhythm season pubertal onset heralded well virilization luteinizing hormone level least sleep total sleep deprivation lowers testosterone sleep restriction occurs first half night recovery testosterone sleep disruption impaired old compared young rodents men obstructive sleep apnoea osa low testosterone related obesity rather osa improves weight loss inconsistently continuous positive airway pressure cpap testosterone treatment transiently worsens severity osa need considered contraindication use summarytestosterone treatment unlikely benefit sleep men secondary hypogonadism example due obesity depression contrast management underlying abnormality
spatial patterns land use change due urbanization impact landscape subject ongoing research urban growth scenario simulation powerful tool exploring impacts empowering planners make informed decisions present futures future urban regional environment simulation patch based stochastic multi level land change modeling framework case showing closed inaccessible model benefited integration open source gis describe motivation releasing project open source advantages integrating grass gis free libre open source gis research platform geospatial domain grass gis provides efficient libraries futures model development well standard gis tools graphical user interface model users releasing futures grass gis add simplifies distribution futures across main operating systems ensures maintainability project future describe futures integration grass gis demonstrate usage case study asheville north carolina developed dataset tutorial case study enable researchers experiment model explore potential even modify model applications
internet brought great changes college students lives typical phenomenon students staying late especially freshmen paper intends understand habit staying late university freshmen analyze main influencing factors improve university freshmen healthy sleep habits network era method used self made questionnaire investigate university freshmen universities hangzhou anonymous survey results showed freshmen never stay late freshmen stay late sometimes freshmen always stay late almost freshmen bed vacation freshmen bed results also show freshmen stay late spent time internet staying late becoming common phenomenon among university freshmen network era main reasons include popularity mobile phones convenience internet online social networking lack self control society university freshmen pay attention put efforts together develop healthy sleep habits
density flame retardancy controlled isocyanate based polyimide foam prepared postgrafting method first solution containing prepolymer synthesized dianhydride overdose isocyanates added second solution containing dianhydride derivatives water catalysts surfactants possible reactions preparation discussed obtained fourier transform infrared spectra indicate increased amount imide rings generated increasing molar ratio anhydride isocyanate groups size walls cells became smaller thinner less carbon dioxide escaping air first solution preparation process shown scanning electron microscopy images thermogravimetric analysis curves demonstrated weight loss temperature greater degrees residual weight retention degrees addition differential thermogravimetry curves demonstrated thermal stability decreased byproducts polyimide foams limiting oxygen index increased gradually increasing molar ratio anhydride isocyanate groups meanwhile density obtained polyimide foams ranged molar ratio anhydride isocyanate groups ranged prepared isocyanate based polyimide foams exhibit great flame retardancy lower density wiley periodicals inc
paper presents high resolution voltage reference suitable building high precision magnet power supplies accelerators consists digital signal processor field programmable gate array two digital analog converter dac boards dac board uses two commercial bit converters analog signal processing circuit achieve resolution higher bit proposed voltage reference resolution bit ppm full scale short long term stabilities similar ppm respectively controllability reproducibility output voltage step input similar ppm equivalent bandwidth voltage reference similar khz experimental results show proposed voltage reference may applied many systems require high resolution cost effective voltage reference good long term stability voltage reference interfaced ethernet including epics rsc elsevier rights reserved
backgroundinsomnia comorbid internalizing externalizing psychiatric disorders however extent etiologic influences insomnia common psychopathology overlap unclear limited genetically informed studies insomnia internalizing disorders studies overlap exist externalizing disorders methodswe utilized twin data virginia adult twin studies psychiatric substance use disorders total insomnia internalizing disorders major depressive disorder mdd generalized anxiety disorder gad alcohol abuse dependence aad assessed two time points antisocial personality disorder aspd assessed cholesky decompositions performed openmx longitudinal measurement models run available phenotypes reduce measurement error resultsthe latent additive genetic influences insomnia overlapped significantly females males mdd shared completely gad significant overlap latent unique environmental influences overlap ranging across disorders contrast less genetic overlap insomnia externalizing disorders insomnia heritability shared aad aspd latent unique environmental overlap insomnia externalizing disorders negligible conclusionsthe evidence substantial genetic overlap insomnia stable aspects internalizing disorders suggests may insomnia specific genes investigation unique environmental factors important understanding insomnia development modest overlap insomnia externalizing disorders indicates disorders genetically related largely etiologically distinct
article develops answers question psychiatric processes general psychological predisposition makes nondiagnosed people susceptible media violence consumption way would lead lifelong aggressive behavior authors discuss assumptions make question trying answer review factors known precipitate destructive aggressiveness clarify environmental exposures small part long list precipitants discuss neuroplasticity brain interacts structurally functionally altered environment introduce resilience enables respond functionally trauma others less mention work examining exposure violence within schools impact school climates vulnerable children illustrating importance social factors relating aggression authors conclude reformulating question allowing human psychopathological reactions seen glorious nonparsimonious complexity
aimsmechanisms underlying pain perception afferent hypersensitivity central sensitization may impact overactive bladder oab symptoms however little known associations oab symptom severity pain experience presence comorbid chronic pain syndromes study examined relationships oab symptoms somatic symptoms specific chronic pain conditions central sensitization believed play primary role community based sample adult women oab methodswe recruited adult women oab complete questionnaires assessing urinary symptoms pain somatic symptoms preexisting diagnoses central sensitivity syndromes analyzed effects overall bodily pain intensity general somatic symptoms diagnoses central sensitivity syndromes oab symptom bother health related quality life resultsof women study half stated urge urinate associated pain pressure discomfort participants reported wide range oab symptoms health related quality life significant positive correlation oab symptoms somatic symptoms well overall pain intensity women met diagnostic criteria fibromyalgia yet women demonstrated significantly increased oab symptom burden decreased oab quality life compared without fibromyalgia conclusionwomen severe oab symptoms reported increased general somatic symptom burden increased overall body pain intensity especially women fibromyalgia findings suggest attributes pain morbidity chronic pain conditions may impact experience oab symptoms many women neurourol urodynam wiley periodicals inc
order study dynamic responses long span suspension bridge cfrp cables suspension bridge cfrp cables span designed dynamic responses suspension bridge steel cables cfrp cables analyzed ansys software effects structural design parameters dynamic responses investigated analysis results show basic frequency vertical lateral bending twist suspension bridge cfrp cables increased contrast suspension bridge steel cables applying cfrp cable little effect mode shapes frequencies horizontal bending longitudinal floating stiffening girder central buckle could improve dynamic behavior suspension bridge frequency always increase stiffness main cables increase stiffness suspender relatively little effect dynamic behavior entire suspension bridge
dramatic growth senior population community assessment health needs older adults become increasingly important telephone surveys routinely used assess variety senior issues identified limitations telephone surveys however suggest importance using supplementary methods article reports findings assessment health issues seniors community rapidly increasing population seniors core assessment tool telephone survey randomly selected sample community residing seniors two supplementary methods survey provide regular care seniors focus groups minority aand low income seniors three methods provided valuable information individually collectively findings support assertion made authors supplementary evaluation especially informative subgroups valuable comprehensive characterization health community residing seniors
objectives explored educational gradient mortality atrial fibrillation patients design prospectively followed patients hospitalized primary discharge diagnosis cardiovascular disease norway project average length follow years mortality educational level assessed cox proportional hazard models population attributable fractions paf calculated analyses stratified age years age adjusted age gender medical intervention charlson comorbidity index results patients died end among younger patients low education years confidence interval cause mortality relative college university education similar results observed cardiovascular mortality disparities mortality greater among younger older patients paf confidence interval observed educational level high school vocational school less versus higher education younger patients conclusions increasing educational level associated better prognosis suggesting underlying education related behavioral medical determinants mortality considerable proportion mortality within years following hospital discharge could prevented
within framework eurofusion program dual coolant lithium lead dcll one four breeder blanket concepts investigated candidates demo dcll uses pbli main coolant tritium breeder tritium carrier neutron multiplier main structures including first wall cooled helium program proposed next years consider dcll version limited degrees order allow use conventional materials technologies first year eurofusion activities draft design dcll proposed main blanket performances adapted new specifications cad model demo breeder zone toroidally divided four parallel pbli circuits separated stiffening grid radial walls pbli flow routing designed maximize amount thermal power extracted flowing pbli avoid occurrence reverse flows due volumetric heating thermal hydraulics magnetohydrodynamic neutronics calculations performed first draft design new dcll design employs eurofer alumina eurofer sandwich flow channel insert fci
conformal maps planar domains important tool geometry processing used shape deformation image warping riemann mapping theorem guarantees exists conformal map two simply connected planar domains yet computing map efficiently remains challenging practice one main algorithmic questions correspondence boundaries domains one hand exist number conformal maps two domains thus many potential boundary correspondences yet given full boundary prescription conformal map might exist furthermore approximate boundary fitting enough many applications therefore propose alternating minimization algorithm finding boundary approximating conformal map given initial global alignment two input domains utilize cauchy green complex barycentric coordinates parameterize space conformal maps source domain thus compute continuous map without requiring discretization domain without mapping intermediate domains yields efficient method allows interactively modify additional user provided constraints point point stroke stroke correspondences furthermore show easily generalize setup quasi conformal maps thus enriching space mappings reducing area distortion compare algorithm state art methods mapping planar domains demonstrate achieve less distorted maps inputs finally show applications approach stroke based deformation constrained texture mapping
recently kind renewable fuel low grade biogas researched apply internal combustion engine paper experimental study conducted study influence injection strategies efficient utilization low grade biogas reactivity controlled compression ignition rcci mode port fuel injection biogas cylinder direct injection diesel based modified electronic controlled high pressure directly injected compression ignition engine considered high proportion inert gas biogas four components simulated gas vol selected test fuels simulate biogas effects several injection control parameters pilot injection timing main injection timing common rail pressure pilot injection ratio combustion emissions analyzed detail research demonstrates main injection timing effectively control combustion phase excessive early pilot injection timing leads retard combustion emissions relatively high due homogenous charge biogas nox smoke emissions effectively controlled rcci mode indicated thermal efficiency biogas diesel reach elsevier ltd rights reserved
study qualitative quantitative analysis carbonyl compound emissions exhaust gas homogeneous charge compression ignition hcci spark ignition engines trapped dinitrophenylhydrazine dnph solution investigated hydrazine formed analysed means hplc detected ultraviolet detector standards carbonyl dnph derivatives identified compared engine emissions catalyst emissions compounds formaldehyde hcho acetaldehyde chcho acrolein chcho interest scientific regulatory communities due suspected likely impacts human health frequent exhaust products two engine operation modes acetaldehyde followed acrolein mtolualdehyde benzaldehyde chcho formaldehyde aldehydes exhaust gas observed small percentage contribution carbonyl compounds total hydrocarbon thc emissions study lies hcci stoichiometric hcci lean operation results indicate engine operating conditions appear exert strong influence total mass emissions carbonyls measured catalyst prototype catalytic converter eliminates carbonyls species exhaust combustion modes except acetaldehyde species negative conversion presented engine conditions prototype catalyst showed high efficient conversion aromatic unsaturated aldehyde engine modes published elsevier ltd
background different conflicting data published concerning thyrotropin tsh levels among small gestational age sga appropriate gestational age aga newborns hypothesis study sga preterm infants higher tsh levels underweight methods cross sectional study analyzed tsh levels preterm newborns negative congenital hypothyroidism screening result tsh secondary variables sex birth weight sga aga days life blood extraction maternal origin gestational age twin two multiple linear regression models constructed comparing tsh levels sga aga score birth weight remaining variables results sample including preterm infants obtained male twins sga tsh concentrations sga infants aga infants negative correlation tsh levels score weight newborn multivariate analysis comparing tsh levels sga aga gave following sga latin american mother days life blood extraction gestational age weeks using score weight associations maternal origin north africa days life blood extraction gestational age weeks score weight conclusions multivariate analysis suggests tsh concentrations higher sga infants aga infants taken account establishing reference interval appropriate population clinical relevance remains unknown lines research opened may allow better understanding long term morbidities newborns
hepatitis virus hcv leading cause end stage liver disease europe united states common reason liver transplant absence antiviral therapy recurrent infection norm subsequent graft hepatitis impaired survival whether may better postpone therapy patients higher risk failure toxicity coupled lower chance liver function improvement likely depends several factors including waiting time center allocation policy presence hepatocellular carcinoma local prevalence anti hcv positive donors
background vast diversity microbes colonizes human gastrointestinal tract referred intestinal microbiota microbiota products thereof indispensable shaping development function host innate immune system thereby exerting multifaceted impacts gut health methods paper reviews effects immunity gut microbe derived nucleic acids gut microbial metabolites well involvement commensals gut homeostasis focus recent findings intention illuminate mechanisms microbiota products thereof interacting host immunity well scrutinize imbalanced gut microbiota dysbiosis lead autoimmune disorders including inflammatory bowel disease ibd type diabetes systemic immune syndromes rheumatoid arthritis results addition well recognized benefits gut occupation ecological niches competition pathogens commensal bacteria shown strengthen gut barrier exert immunomodulatory actions within gut beyond realized impaired intestinal microbiota contribute gut diseases also inextricably linked metabolic disorders even brain dysfunction conclusions better understanding mutual interactions microbiota host immune system would shed light endeavors disease prevention broaden path discovery immune intervention targets disease treatment
studies seasonal variability sleep asked participants think sleep quality varies seasons reveals research hypothesis participants date hypothesis seasonal variation sleep tested large population based fully blinded study aim current study investigate monthly variations sleep problems geographic region norway large seasonal differences daytime light using data general health survey authors access information sleep general population collected across seasons years without linking sleep seasonal variation participants mean age years nord trondelag health study referred hunt provided reports insomnia symptoms time bed months except july mean prevalence insomnia symptoms evidence seasonal variation reports insomnia symptoms time bed found null findings marked contrast previous seasonality studies sleep previous studies reporting seasonal variations sleep insomnia might subject publication biases lack blinding research hypothesis
paper presents computationally efficient raychowdhury compact model schottky barrier carbon nanotube field effect transistor cntfet order achieve accurate compact model shot noise sources added assessment circuit performances operational amplifier amp designed using cntfet compact model results compared conventional cntfet
production heat key characteristic machine behavior heat sources come mainly energy losses electrical copper magnetic iron aerolic fans mechanical bearings temperature changes described owing thermal conduction convection radiation equations understand design machine important construct dedicated model know every physical loss aim therefore build static thermal model adapted simulation sizing claw pole car alternators currently cars internal combustion engines generators rotors wire wound doubly excited concentrated winding small permanent magnets self air cooled fans paper proposes nodal model nodes taking heat transfers space directions account thermal characterization machine permitted four physical parameters varying temperature rotating velocity omega shown sufficient deduce model conductances properties follows thermal exchange coefficients due free forced convection air gap cavity thermal exchange coefficient due free superficial convection external surface thermal equivalent conductivity within bearings consistency usefulness model identifications checked numerical studies measurements
background intravenous infusion pmol min pituitary adenylate cyclase activating polypeptide pacap induces migraine like attacks migraine patients without aura conducted pilot study investigated lower doses pacap exert similar migraine inducing abilities methods randomly allocated six patients receive intravenous infusion pmol min pacap minutes double blind three way cross study headache migraine characteristics recorded hospital hours post hospital hours phases results pacap induced migraine like attacks one six patients pmol two six patients pmol three six patients pmol patients reported head pain pmol min whereas five six participants reported head pain pmol min found difference three doses auc headache intensity hour observation period exploratory analysis showed significant difference pmol pmol conclusion trend dose response relationship dose pacap incidence migraine observed suggest pmol min pacap optimal dose induce migraine like attacks
objective investigate possible role phthalate ubiquitous chemical used consumer products pathogenesis uterine leiomyoma design experimental prospective case control study using human samples setting university hospital patient fifty three women histologic evidence uterine leiomyoma surgical controls without leiomyoma intervention human myometrial leiomyoma cells treated thylhexyl phthalate dehp main outcome measure cell viability assay western blot analyses vitro dehp treatment high performance liquid chromatography electrospray ionization tandem mass spectrometry cases controls result vitro treatment dehp led increased viability increased expressions proliferating cell nuclear antigen cell lymphoma protein type collagen myometrial leiomyoma cells urinary concentration mono ethyl carboxypentyl phthalate higher women leiomyoma compared controls conclusion findings suggest exposure phthalate may play role pathogenesis uterine leiomyoma enhancing proliferative activity exerting antiapoptotic effect increasing collagen contents myometrial leiomyoma cells american society reproductive medicine
high end data processing systems databases execution concurrency level rises continuously since introduction multicore processors happens premises cloud systems buffer pool management high scalability plays important role overall system performance scalability buffer pool management largely determined data replacement algorithm major component buffer pool management seriously degrade scalability designed implemented properly root cause use lock protected data structures incurs high contention concurrent accesses common practice modify replacement algorithm reduce contention lock approximating lru replacement clock algorithm partitioning data structures using distributed locks unfortunately modification usually compromises algorithm hit ratio major performance goal may also involve significant effort overhauling original algorithm design implementation paper provides general solution improve scalability buffer pool management using replacement algorithms data processing systems physical premises machines virtual machines cloud instead making difficult trade high hit ratio replacement algorithm low lock contention approximation design system framework called wrapper eliminates almost lock contention without requiring changes existing algorithm wrapper use dynamic batching technique prefetching technique reduce lock contention retain high hit ratio implementation wrapper postgresql adds lines code increase throughput two folds compared replacement algorithms lock contention running tpc like tpc like workloads
histone deacetylases hdacs involved epigenetic modulation aberrant expression demonstrated myeloproliferative neoplasms mpn hdac inhibition shown inhibit jak stat signaling hematopoietic cells mpn nevertheless role hdac expression bone marrow mesenchymal stromal cells msc assessed current work describe hdac significantly expressed msc jak positive mpn compared healthy donors msc using selective hdac inhibitor pci verified subsequent decrease protein mrna expression hdac linked increased apoptosis malignant msc whereas effects normal msc addition hdac inhibition mpn msc also decreased capacity maintain neoplastic hematopoiesis increasing apoptosis cell cycle arrest colony formation jak hematopoietic cells mechanistic studies using different mpn cell lines revealed pci induced apoptosis enhanced cultured jakvf msc decreased colony formation phosphorylation stat stat summary show first time inhibition hdac msc jak mpn patients selectively decreases hematopoietic supporting ability suggesting hdac may potential therapeutic target setting acting hematopoietic cells also malignant microenvironment
background smokers mental illness health care providers often concerned smoking cessation worsen mental health smokers mental illness tend nicotine dependent experience severe symptoms nicotine withdrawal difficult distinguish psychiatric symptoms addition smoking cessation increase blood levels hence side effects psychotropic medications improved monitoring nicotine withdrawal medication side effects may help distinguish temporary withdrawal symptoms psychiatric symptoms facilitate targeted treatment help smokers mental illness manage acute phase nicotine withdrawal objective aim research examine acceptability feasibility quitline counselors implementing structured assessments nicotine withdrawal common medication side effects people mental illness quitting smoking using telephone smoking cessation service methods monitoring involves administering pre cessation contact post cessation minnesota nicotine withdrawal scale assessing eight symptoms anger anxiety depression cravings difficulty concentrating increased appetite insomnia restlessness adverse side effects checklist symptoms example dry mouth increased thirst following day update training mental health quitline counselors asked offer assessments callers disclosing mental illness addition usual counseling group interviews counselors conducted months later examine implementation barriers benefits results barriers included awkwardness integrating new structured practice counseling difficulty limiting callers content new items initial anxieties respond changes symptoms benefits included ability provide objective feedback changes symptoms identified early benefits quitting provided reassurance clients provided opportunity early intervention symptoms worsened conclusions structured monitoring withdrawal symptoms medication side effects able integrated quitline counseling valued counselors clients given evidence benefits limited pilot study recommend considered larger scale adoption quitlines
despite advances women equality perhaps result sexist humor prevalent society research topic lacked realism way humor conveyed participants examined perceptions men women use sexist humor embedded jokes printed facebook profiles present sexist humor participants manipulated gender individual profile man woman type joke presented anti men anti women neutral groups design found men women rated anti women jokes sexist neutral humor women also rated anti men jokes sexist also found men displayed anti women humor perceived less positively men displaying anti men humor women displaying either type humor findings suggest may different gender norms place joke tellers regarding acceptable target sexist humor
gender role set societal norms dictating types behaviors considered desirable appropriate person based sex however socially constructed gender roles lead equal rights genders also severe disadvantages discrimination remarkable variety different countries based social indicators gender statistics women arab region average disadvantaged economically politically socially women regions according banduras social learning theory argue profound knowledge historical contributions ancient egyptian female pioneers science arts even ruling egypt pharaohs improve today gender role egypt middle eastern countries therefore article provides elaborate review gender role women ancient egypt outlining prominence influence admiration ancient societies discusses possible psychological impact knowledge today gender role suggest future empirical research investigate enhancing knowledge women ancient egypt improve today gender role egypt middle east bandura social learning theory outlined possible framework future research
chronic migraine debilitating disorder significant impact patients society nearly migraineurs frequently reported light sensitivity headache attack pituitary adenylate cyclase activating polypeptide pacap plays important role activation trigeminal system migraine pain identify effect chronic ghrelin treatment endogenous pacap associated symptoms migraine experimental chronic migraine model induced intermittent intraperitoneal injection nitroglycerin ntg photophobia anxiety like behaviors determined modified elevated plus maze days light dark box days blood levels pacap cortisol assessed enzyme linked immunosorbent elisa kits chronic injection ntg evoked photophobia anxiety like behaviors treatment ghrelin days effectively attenuated photophobia anxiety like behaviors paradigms found ntg increased blood levels pacap cortisol significantly reduced ghrelin treatment additionally staining hematoxylin eosin revealed ghrelin reduced ntg induced increase number satellite glial cells trigeminal ganglion furthermore first time showed repeated administrations ntg increased white blood cell wbc counts mean platelet volume mpv decreased platelet counts results indicated ghrelin decreased migraine associated symptoms possibly attenuating endogenous pacap cortisol levels therefore ghrelin may hold therapeutic potentialities managing chronic migraine
introduction aberrant misfolded forms prion protein described causative agents rare transmissible spongiform encephalopathies addition proteins associated frequently occurring neurodegenerative disorders alzheimer parkinson shown share prion like properties spread disease brain areas covered interest prion phenomenon crystallized series computational methods aimed uncovering prion like proteins proteome level programs rely identification sequence signatures similar yeast prions whose structural conversion driven specific domains enriched glutamine asparagine residues myriad prion like candidates similar yeast predicted exist organisms across kingdoms life review role prions prionoids prion like proteins health disease special focus algorithms databases developed prediction classification expert commentary computational approaches provide novel insights prion like protein functions regulation role disease
television drama series nowadays one common television formats entertainment program genre one hand heroes heroines series mirror social cultural realities changes whereas offer imitation models shape ideas among things male female means first three decades existence television series predominantly showed stereotypical male female relationships active heroes passive housewives last two decades witnessed changes question stereotypical depiction gender roles television started presenting new main heroines equally courageous independent intelligent violent male partners although continue perpetuate stereotypical depiction terms physical attractiveness sex appeal primarily refers protagonists north american series buffy nikita xena alias revenge rogue etc paper discusses characteristics new heroines leading roles potential redefine female character
due degradation osteoarthritic cartilage post traumatic ptoa tissues challenging study manipulate vitro study chondrocytes isolated either ptoa meniscal release model normal contralateral limb cartilage canine knee joints used form micropellets assess maintenance chondrocyte phenotype vitro media samples micropellet cultures used measure matrix metalloproteinase mmp chemokine cytokine concentrations significant differences matrix synthesis observed function disease chondrocytes generally synthesizing extracellular matrix increasing time culture donor dependent differences detected luminex multiplex analysis pellet culture media showed disease time dependent differences interleukin keratinocyte chemoattractant like protein mmp mmp mmp differentially expressed memory diseased phenotype persists first weeks culture results demonstrate potential use chondrocytes animal model study phenotype alterations progression treatment orthopaedic research society
background knee dislocations resulting multiligament knee injuries mlis usually associated high energy mechanisms motor vehicle accidents sports injuries however obese patients risk mlis simple falls termed ultra low velocity ulv dislocations injuries occur obese patients activities daily living may associated higher associated risks complications hypothesis ultra low velocity knee dislocations occur commonly obese female patients associated higher risks neurovascular injuries significant perioperative complications compared mlis study design case series level evidence methods records consecutive patients mlis identified year period charts reviewed identify cohort patients mechanisms consistent ulv dislocations cohort compared patients mlis additionally ulv patients neurovascular injuries compared without neurovascular injuries results average body mass index bmi significantly higher ulv cohort compared patients mlis injuries occurred commonly female patients ulv cohort compared patients mlis peroneal nerve injuries occurred commonly ulv cohort compared patients mlis vascular injuries respectively postoperative complications common among ulv mli patients regardless neurovascular injury status seventeen patients intact group neurovascular injury group significant complications postoperatively significantly higher overall complication rate noted ulv mli group compared entire mli cohort additionally ulv mli cohort higher reoperation rate wound infection rate deep venous thrombosis rate presence vascular claudication conclusion ultra low velocity knee injuries occur patients greater bmi frequently female patients higher rates concomitant neurovascular injuries compared mlis additionally significantly greater incidence postoperative complications expected ligament reconstruction population compared mlis
although business application data stored relational databases programming languages wire formats integration middleware systems table centric due costly format conversions data shipments faster computation trend push integration operations closer storage representation address alternative case defining declarative table centric integration semantics within standard integration systems replace current operator implementations well known enterprise integration patterns equivalent memory table processing show practical realization conventional integration system non reliable data intensive messaging example results runtime analysis show table centric processing promising already standard single record message routing transformations potentially excel message throughput multi record table messages
article considers ensuring secure data processing distributed computer systems dcss important certain class computing tasks approach resource management dcss proposed makes possible take account according user requirements time spent execution task security level system resources involved execution
one main challenges water management determine current water use condition availability future generations hence sustainability study proposes use water footprint indicator assess environmental sustainability water resources management river basin level current study presents methodology developed applies case study relatively new indicator measures total volume freshwater used production factor application ever growing evaluation water use production processes calculation involves water resources blue precipitation stored soil green pollution grey provides comprehensive assessment environmental sustainability water use river basin methodology based upon simulation anthropised water cycle conducted combining hydrological model decision support system methodology allows assessment environmental sustainability water management different levels ante analysis decisions made water planning process affect sustainability sustainability study carried segura river basin srb south eastern spain srb among complex basins europe given special peculiarities competition use overexploitation aquifers pollution alternative sources among others results indicate blue water use sustainable due generalised overexploitation aquifers also reveal surface water pollution sustainable mainly caused phosphate concentrations assessment future scenarios reveals problems worsen additional measures implemented therefore water management srb environmentally unsustainable short medium term elsevier rights reserved
due low complexity organic rankine cycle considered one best options waste heat recovery low degrees average degrees temperatures technical economic study conducted work order increase efficiency electricity production thus reduce fuel consumption polluting gas emission internal combustion engines purpose two organic rankine cycle sets suggested first one facing deployment water shortage areas organic rankine cycle using cooling tower condensing system another one water supply condenser made urban water net simulated systems able increase electricity production almost toluene working fluid economic analysis based engineering chemical cost plant index model showed financial return implementation organic rankine cycle system occur six years thus noted organic rankine cycle system installed areas water abundance without much yield loss despite appropriate technological solution recover waste heat present internal combustion engines exhaust gas still lacks governmental incentives wide application system elsevier ltd rights reserved
purpose paper seeks examine whether violence embedded stories ads contribute advertising effectiveness along lines well researched elements celebrity endorser physically attractive model specifically paper aims assess whether violent content story adds excitement perceptions overall evaluations attitude toward attitude toward advertised product design methodology approach paper uses experimental approach comprising two studies participants randomly allocated ads different levels violence story findings main finding representations real violence opposed staged violence produced higher levels excitement attitude toward story attitude toward attitude toward advertised product compared violence effects however moderated level congruence story advertised product highest response levels obtained ads violent story content dealing explicitly advertised product originality value finding violent stories ads positive charge consonant assumption violence narrative device may heighten excitement created story also accord observation many consumers appear relish stories violent content yet main finding challenges existing research violent ads violence consists image visually exposed brand questions dominant approach media violence research emphasizes negative effects media violence
gait analysis using wearable wireless sensors economical convenient effective way provide diagnostic clinical information various health related issues work custom designed low cost wireless gait analysis sensor contains basic inertial measurement unit imu used collect gait data four patients diagnosed balance disorders additionally three normal subjects performing dynamic gait index dgi tests wearing custom wireless gait analysis sensor wgas small wgas includes tri axial accelerometer integrated circuit two gyroscopes ics texas instruments msp microcontroller worn subject position dgi tests raw gait data wirelessly transmitted wgas near real time gait data collection analysis order perform successful classification patients normal subjects used several different classification algorithms back propagation artificial neural network ann support vector machine svm nearest neighbors knn binary decision trees bdt based features extracted raw gait data gyroscopes accelerometers range used input feature overall classification accuracy obtained ann svm knn using bdt similar high classification accuracy results also achieved standard deviation values used input features classifiers results show gait data collected low cost wearable wireless gait sensor effectively differentiate patients balance disorders normal subjects real time using various classifiers success may eventually lead accurate objective diagnosis abnormal human gaits underlying etiologies future patient data collected
reciprocating friction characteristics magneto rheological fluid aluminum magnetic field different loads oscillation frequencies studied fluids worked reciprocating motions dampers automobiles surface polishing finishing thus experiments carried evaluate reciprocating friction characteristic fluid aluminum obtained data tests sorted groups depending various loads oscillation frequencies analyze relationship test condition travel cycle surfaces specimens compared measuring surface roughness observing surface images performance reciprocating friction characteristics fluid aluminum evaluated analyzing experiment results
neuraxial labor analgesia initiated via combined spinal epidural cse stand alone epidural pros cons techniques outlined review recent years computer integrated patientcontrolled epidural analgesia pcea programed intermittent epidural boluses pieb developed adding continuous infusion pcea maintenance neuraxial analgesia postdural puncture headache pdph fever occur secondary labor epidural clinical relevance care givers insights mechanism epidural fever treatment strategies pdph outlined due increase obesity specific considerations patient group discussed new data presented remifentanil ultra shortly acting opioid used obstetric analgesia without breaking new data use nitrous oxide especially midwives kind renaissance discussed
previous study demonstrated erythrocyte rich thrombi contain inflammatory cells reflect high thrombus burden leading impaired myocardial reperfusion myocardial infarction aim study investigate utility quantified frequency domain optical coherence tomography oct signal analysis evaluating erythrocyte rich thrombus vivo materials evaluated specimens coronary artery thrombus obtained thrombectomy catheter patients underwent primary percutaneous coronary intervention thrombi immersed saline immediately thrombectomy oct image acquisition performed vivo quantitative analysis contiguous frames performed dedicated automated software oct system software light lab inc maximum thrombus area mean signal intensity msi normalized standard deviation signal nsd evaluated thrombi stained using double staining phosphotungstic acid hematoxylin eosin enable automatic extraction erythrocyte fibrin computer assisted analysis performed using dedicated image processing software winroof mitani corp tokyo japan color identification erythrocyte area erythrocyte rich thrombus defined erythrocyte erythrocyte area total thrombus area showed significantly lower msi cut point prediction erythrocyte rich thrombus defined msi sensitivity specificity area curve respectively present vivo study suggested utility quantified oct signal analysis detection erythrocyte rich thrombus
objective review prenatal development maxillary sinus perspective sinus surgery study design cross sectional study setting basic embryology laboratory subjects methods morphometry morphology maxillary sinus ostium studied stereomicroscopy human fetuses week fetuses obtained fetal collection school medicine universidad autonoma nuevo leon approval granted ethics committee statistics applied results maxillary sinus begins development week week anterior posterior diameter mean ossification medial wall absent floor located attachment inferior turbinate septa recesses temporarily observed variations shape observed however oval shape persisted maxillary sinus hypoplasia found although asymmetry present cases ostium located anterior third ethmoid infundibulum final dimensions length width mean length ostium lamina papyracea nasolacrimal duct one case double maxillary sinus observed significant difference variables accordance age found conclusion knowledge prenatal development maxillary sinus improves perspective sinus surgeon helps understanding postnatal anatomy especially children
simple theoretical framework egalitarian gender role attitudes emerge women participate labor market advanced western nations enjoy relatively gender egalitarian working environments consequently egalitarian gender attitudes east asian counterparts women east asian societies hand said support conditions resulting stagnant female labor force participation traditional attitudes toward gender roles taiwan however women economically active two east asian societies japan south korea even though women three societies favor traditional gender division labor thus taiwan women experiencing inconsistencies active working lives traditional values study hypothesizes inconsistency coexistence old new reflected mind set women using comparative data east asian social survey analyzed gap responses questions gender attitudes relation working conditions general gender role attitudes found significant differences size gaps taiwanese women expressed egalitarian views insofar questions concerned practical economic interests retained basic traditional attitudes towards gender roles homes gap larger taiwan japan south korea
objective park gene encodes parkin component multiprotein ubiquitin ligase complex targets substrate proteins proteasomal degradation park mutations frequently associated parkinson disease structural alterations also described patients neurodevelopmental disorders ndd suggesting pathological effect ubiquitous neurodevelopmental neurodegenerative brain processes present study aimed define critical regions ndd within park materials methods clarify park involvement ndds examined frequency location copy number variants cnvs identified patients sample reported literature relevant databases compared control populations results overall frequency park cnvs higher controls ndd cases however closer inspection cnv location park showed frequency cnvs targeting parkin terminal corresponding ring ring rbr domain responsible parkin activity significantly higher ndd cases controls contrast cnvs targeting terminal parkin including domains regulate ubiquitination activity common cases controls conclusion although park may pathological factor ndds likely variants pathogenic conclusive assessment park variant pathogenicity requires accurate analysis location within coding region encoded functional domains copyright wolters kluwer health inc rights reserved
passive removal stone fragments irrigation stream one characteristics continuous flow pcnl instruments far physical principle called vacuum cleaner effect fully understood yet aim study empirically prove existence vacuum cleaner effect develop physical hypothesis generate mathematical model phenomenon empiric approach common low pressure pcnl instruments conventional pcnl sheaths tested using vitro model flow characteristics visualized coloring irrigation fluid influence irrigation pressure sheath diameter sheath design nephroscope design position nephroscope assessed experiments digitally recorded slow motion analysis deduce physical model tested nephroscope design could observe vacuum cleaner effect increase irrigation pressure reduction cross section sheath sustained effect slow motion analysis colored flow revealed synergism two effects causing suction transportation stone first time model showed flow reversal sheath integral part origin stone transportation vacuum cleaner effect application bernoulli equation provided explanation effects confirmed experimental results widen understanding pcnl conclusive physical model explains fluid mechanics vacuum cleaner effect
paper reports source follower based active filter topology front ends wideband systems proposed active filter noise figure bandwidth improved adopting proposed sub omega source follower replaces conventional operational amplifier based unity gain buffer simply changing location filter applying proposed scheme conventional sallen key filter also improves stopband rejection performance furthermore proposed filter topology ultimately suppresses offset voltage flicker noise unity gain buffer active circuit filter proposed biquad filter implemented cmos measurements exhibit dbm iip dbm input noise figure mhz bit tunable frequency range proposed biquad filter consumes supply chip occupies
music draws body space time relationships offer sacred experience musicking makes personal social emotional spiritual connections people cultural identity formed arts spirituality music medium people explore identities study examines music facilitates holistic development two melbourne born chinese australian christian musicians confucian evolving self model maslow hierarchy human needs music education aims offer conceptualising scaffolds illuminate self discovery interpretative phenomenological analysis used report multiple semi structured interviews undertaken three years study considered interaction various value systems fusion confucianism christian psychological cultures process musical development identity formation fills research gap complements existing approaches understanding social contexts influencing acquisition musical skills musicians occupational choices permissive parenting participants experienced might account able follow career music without familial resistance current findings advocate music education spiritual aspects musical experiences perceived mirror fostering holistic development participants
ray screening systems used safeguard environments access control paramount importance security checkpoints placed entrances many public places detect prohibited items handguns explosives generally human operators charge tasks automated recognition baggage inspection still far perfect research development ray testing however exploring new approaches based computer vision used aid human operators paper attempts make contribution field object recognition ray testing evaluating different computer vision strategies proposed last years tested ten approaches based bag words sparse representations deep learning classic pattern recognition schemes among others method present brief explanation show experimental results database provide concluding remarks discussing pros cons method order make fair comparisons define common experimental protocol based training validation testing data selected public gdxray database effectiveness method tested recognition three different threat objects handguns shuriken ninja stars razor blades experiments highest recognition rate achieved methods based visual vocabularies deep features accuracy strongly believe possible design automated aid human inspection task using computer vision algorithms
objectives existing studies sleep behavioral outcomes mostly correlational longitudinal data limited current longitudinal study assessed sleep duration sleep quality may causally linked daytime functions including physical health physical well daytime sleepiness psychological health mood self esteem academic functioning school grades study effort mediation role mood relationship sleep quality sleep duration daytime functions also assessed methods sample chinese students aged hong kong macau completed self reported questionnaires online across three academic semesters sleep behaviors assessed sleep timing questionnaire sleep duration weekday weekend sleep discrepancy pittsburgh sleep quality index sleep quality physical health world health organization quality life scale brief version physical well epworth sleepiness scale daytime sleepiness psychological health depression anxiety stress scale mood rosenberg self esteem scale self esteem academic functioning grade point average college student expectation questionnaire study effort results structural equation modeling bootstrap resample showed controlling demographics participants daytime functions baseline academic functions physical psychological health predicted duration quality sleep sleep behaviors directly predicted daytime functions others indirect effect daytime functions negative mood anxiety conclusion sleep duration quality direct indirect via mood effects college students academic function physical psychological health findings underscore importance healthy sleep patterns better adjustment college years elsevier inc rights reserved
considerations energy density power calendar life critical effectively develop advanced secondary systems next generation battery applications requiring multiple features including long life large cycle count high energy density high power new strategies needed rational design electroactive materials electrodes article discusses several conceptual approaches exploration examples research group first approach systematic synthesis materials structures facilitating ion insertion deinsertion high voltage energy density control materials properties surface area particle size particular crystallite size second approach investigation novel electrode structures substrates increase energy density capacity retention cycling developed strategies minimizing passive components third approach investigation catalysts metal air batteries cathode active material drawn air rather carried battery electrochemical society japan rights reserved
background estimated prevalence irritable bowel syndrome ibs impact patient reported health related quality life qol university based population aged years bogota colombia methods study cross sectional design students faculty staff aged years pontificia universidad javeriana bogota colombia randomly selected invited complete electronic survey containing rome iii ibs diagnostic questionnaire ibs specific qol instrument ibs qol results total individuals participated study prevalence ibs ibs constipation common subtype overall ibs qol score indicated qol impairment ibs unsubtyped patients highest overall qol constipation diarrhea mixed unsubtyped ibs non consulters higher ibs qol food avoidance scores ibs consulters conclusion ibs prevalent disorder university based population aged years significant impact qol ibs unsubtyped subjects highest qol compared subtypes food avoidance appears key factor seeking consultation
paper prove possible use techniques specific electromagnetic field synthesis study electrical circuits definition circulant network presented system matrix network circular matrix allows analytical evaluation eigenvalues singular values resonance frequencies calculated exactly demonstrated passive active circulant networks
paper procedure null broadening algorithm design respect nonstationary interference proposed contrast previous works first impose nulls toward regions nonstationary interference based reconstruction interference plus noise covariance matrix additionally order provide restriction shape beam pattern similarity constraint enforced design stage adaptive weight vector computed via maximizing new signal interference plus noise ratio sinr criterion subject similarity constraint mathematically design original problem expressed nonconvex fractional quadratically constrained quadratic programming qcqp problem additional constraint converted convex optimisation problem semidefinite programming sdp techniques finally optimal solution found using charnes cooper transformation rank one matrix decomposition theorem several numerical examples performed validate performance proposed algorithm
paper compares activation false memory traces true memory traces control items incidental learning version deese roediger mcdermott paradigm drm used conjunction lexical decision task ldt one hundred participants read drm lists intermixed non word lists delay manipulated experimental conditions immediate minute minute asked classify actually studied items cis new words non words ldt results showed independent delay classification latency cis actually studied words active matched control items moreover results showed delay affects activation true false memories rate overall results seem support hypothesis false memories trace becomes additive traces integrated episodic memory features true memories
present iso epc generation compatible battery free rfid tag designed hazardous material monitoring application tag wirelessly powered sensor device incorporates general purpose microprocessor enable development specialized sensor applications housed ruggedized enclosure incorporates dual polarized dbi antenna mhz uhf rfid band integrates two custom uhf rfid analog front end asics general purpose msp microcontroller fiberoptic tamper detection loop tag power threshold dbm due power requirements fiber optic tamper detection loop measured operating range dbm eirp epc generation reader
recent years green building technologies gbts gradually implemented minimize negative impacts construction industry environment economy society order encourage widespread adoption gbts better deeper understanding drivers implementing gbts necessary study aims identify major drivers gbts implementation methodological framework used consists comprehensive literature review questionnaire survey international green building experts rather experts particular country results statistical analyses expert responses indicate top five drivers implementing gbts energy efficiency reduced environmental impact water efficiency occupants health comfort satisfaction company image reputation results test analysis confirm drivers examined perceived significant kendall concordance test shows though experts different countries diverse backgrounds good consensus reached rankings drivers mann whitney test also verifies absence significant differences among experts ranking drivers findings study contribute deepened understanding major factors greatly drive gbts implementation could also encourage industry practitioners stakeholders aiming achieving better construction sustainability implement gbts future perspective international experts study makes contribution body knowledge gbts implementation drivers important gbts promotion elsevier ltd rights reserved
electricity networks isolated neutral point type commonly used ships mainly caused need ensure continuity supply electrical equipment decides appropriate operation vessel occurrence leakage current values dependent components transverse impedance carries risk fire article presents fire risk occurs ships aspect capacitive leakage currents currently measure protection monitor condition insulation signalization case exceeding limit values article shows system limiting leakage currents ship electricity networks type via active compensation method use controlled current sources
among many factors influence success software project software process model employed essential one improper process model time consuming error prone cost expensive lower quality software therefore choose appropriate software process model important problem software development current works focus selection criteria often lead subjective results paper propose software process model recommendation method help project managers choose appropriate software process model new project early stage development process according historical software engineering data proposed method casts process model recommendation classification problem first evaluates different combinations alternative classification attribute selection algorithms best one used build recommendation model historical software engineering data constructed recommendation model used predict process models new software project data also analyze mutual impacts process models different types project factors help managers locate suitable process model found process models also responsible defect count defect severity software change experiments data sets different development teams different countries show average recommendation accuracy method reaches makes potentially useful practice elsevier inc rights reserved
two interesting problems axe considered enriching curriculum strength materials course light recently developed functionally graded materials fgms characterized smooth variation elastic modulus problems associated buckling columns variable flexural rigidity along axis column simple semi inverse method proposed determining closed form solutions axially inhomogeneous columns order presentation given one package conventional problems also recapitulated along novel ones main approach adopted use second order differential equation instead fourth order one obtained integrating twice physical meaning since could derived based moment equilibrium essentially idea utilized textbook timoshenko gere difference paper develops semi inverse formulation
nonverbal communication using social cues like gestures governs great part daily interactions proposed people autism spectrum disorder asd show deviant processing social cues throughout social cognitive development however social cues always convey intention communicate hence aim study test sensitivity adolescents adults asd neurotypical controls social cues high communicative pointing low communicative values grasping purpose employed spatial cueing paradigm cue types compared saccadic reaction times srts conditions target appeared location congruent versus incongruent direction cue results showed adolescents adults asd slower srts incongruent relative congruent condition cue types reflecting sensitivity cues additionally mental effort processing social cues assessed means pupil dilation analysis revealed individuals without asd required mental effort process incongruent compared congruent cues cues higher communicative value posed processing load asd group findings suggest perception social gestures intact asd requires additional mental effort gestures higher communicative value
study corrosion behaviors carbon steel stainless steel investigated water saturated system examine condition injection wells sequestration enhanced oil recovery eor operations model potential nonisothermal effects resulting injection activities including joule thomson effect heat transfer stream surrounding well rock formation adiabatic compression frictional losses accounted model applied onshore offshore wells using realistic data offshore well depth considered vary power function lateral distance sea floor perforation depending scales injection calculations show corrosion rates tubing wall wellhead bottomhole order carbon steel stainless steel rate obtained results study provide insights material selection injection wells design injection operations well leakage monitoring risk assessment wellbores elsevier ltd rights reserved
potential consequence chemotherapy destruction oocytes resulting primary ovarian insufficiency poi young patients often results secondary amenorrhea necessitates hormone replacement therapy regardless etiology poi chance pregnancy low patient population given extent oocyte depletion dysfunction variable possibility spontaneous ovulation hormone replacement therapy subsequent pregnancy however pregnancy desired contraception always discussed patients etiology poi known treatment patients includes estrogen progesterone therapy ensures development secondary sex characteristics acquisition peak bone mass promotion uterine growth maturation early diagnosis patient education emotional support important mitigate long term sequelae
objective association psoriatic arthritis psa disease activity lipid profiles explored studied association active peripheral arthritis enthesitis daclylitis lipid measurements psa methods conducted cross sectional study psa patients enrolled consortium rheumatology researchers north american corrona registry low activity defined clinical disease activity index cdai presence enthesitis dactylitis results patients psa enrolled corrona registry june october complete data cdai lipid measurements patients cdai enthesitis dactylitis moderate high group included women current smokers patients moderate high disease activity shorter duration disease likely prednisone less likely use tumor necrosis factor tnf inhibitors moderate high peripheral disease activity associated abnormal total cholesterol odds ratio abnormal triglycerides adjusting gender duration psa smoking body mass index diabetes modified heath assessment questionnaire scores well following medications methotrexate non biologic disease modifying anti rheumatic drugs prednisone tnf inhibitors cholesterol lowering medications fish oil presence enthesitis dactylitis irrespective cdai scores associated abnormal conclusion findings suggest association peripheral joint inflammation lipid dysregulation psa studies needed determine treating psa improves lipid profiles cardiovascular mortality elsevier inc rights reserved
fully functional succinct tree representation navarro sadakane supports large number operations constant time using bits however full idea hard implement simplified version lgn operation time implemented shown practical competitive describe new variant original idea much simpler implement worst case time lglgn operations implementation based version experimentally shown superior existing implementations elsevier rights reserved
work presents development kinematic model spur gear pair implementation hydrodynamic bearing multidisciplinary multibody dynamics software models employed simulate behavior planetary gear set typically adopted wind turbines geared transmissions popular choice transmit rotation main rotor electrical generator type turbine compared kinds transmission gearbox compact robust require low maintenance lifetime interesting since turbines usually installed remote places gearbox wind turbine normally composed set spur gears bearings assembled arrangement known epicyclic spur gears generally involute profile allows constant transmission angular speed kinematic constraint gears defined angle surface teeth contact angle known pressure angle design remain constant operation however variation distance gears changes angle also changes direction transmission movement account effect joint described projection absolute velocity contact point gear line action calculated position another important group elements bearings support gear shafts absorb part vibration compensate misalignments teeth surface failures hydrodynamic bearings widely employed turbomachinery due simplicity long life good damping properties features wind turbines benefit hydrodynamic bearing models two dimensional adapted implemented multibody dynamics software development modifications also described work hydrodynamic bearing model easily adapted using procedure finally model wind turbine gearbox presented features using aforementioned elements inside multibody dynamics software highlighted
two experiments examined effects forward associative strength fas backward associative strength bas false recollection unstudied lure items themes constructed four associates strongly related lure item terms fas bas four associates weakly related lure item terms fas bas fas manipulated bas controlled across strong weak associates fas controlled across strong weak associates bas manipulated strong associates presented one font weak associates presented second font test lure items disproportionately attributed source used present lures strong associates compared lures weak associates bas manipulated fas manipulated outcome demonstrates bas fas influence lure item false recollection favours global matching models explanation false recollection explanation offered spreading activation theories
session initiation protocol sip application layer protocol used signaling purposes manage voice connections sip text based protocol vulnerable range denial service dos attacks dos attacks render sip servers sip proxy servers unusable depleting memory cpu time paper consider two types dos attacks namely flooding attacks coordinated attacks detection flooding attacks affect stateless stateful sip servers coordinated attacks affect stateful sip servers model sip operation discrete event system des design new state transition machine name probabilistic counting deterministic timed automata pcdta describe behavior sip operations also identify different types anomalies occur des model appear form illegal transitions violating timing constraints appear number otherwise seen subsequently map various dos attacks sip type anomaly des pcdta learn probabilities various transitions timings delay set nonmalicious training sequences trained pcdta detect anomalies hence various dos attacks sip perform thorough experiment computer simulated sip traffic report detection performance pcdta various attacks generated custom scripts
design solutions addressing climate resilience sustainable development desired policy application yet often encounter friction within design team well designers external community members factors include unfamiliarity issues strategies resistance innovation constraints time budget among others aimed understand design may supported adapting established practice value methodology better address policy goals action research methods adapted standard value methodology process collecting community inputs addressing second law considerations challenges related stakeholder concerns practitioner preferences uncertainty future conditions especially climate change addressed applying multi criteria decision analysis elicit community value expressions absent detailed forecast scenario analysis entropy based qualitative assessment applied proxy resilient approaches adapted value methodology approach applied collaborative innovative design across green buildings net zero military installations regional climate resilient infrastructure systems multi state renewable energy developments examination parties shared inputs indicated general patterns revealing user acceptance cumulative action research across multiple cases study revealed entropy assessment aided systems level problem solving community designer workshops guide problem definition generate designs evaluate alternatives additionally outcomes improved stakeholder input obtained early repeated iteratively main findings drawn practitioner stakeholder responses may provide input shape research practical use field design teams seek practical ways forward complex assignments
single layer pentaband antenna small frequency ratio urban vehicular communication application presented proposed antenna linearly polarized designed cover navigation communication frequencies antenna utilizes square patch radiator loaded inverted slot coupled slot provide resonance navigation frequencies viz ghz communication frequencies viz satellite radio broadcast service srbs ghz mobile services ghz designed antenna exhibits lowest frequency ratio nonoverlapping frequency bands furthermore parametric study carried investigate effect caused change slot parameters antenna aperture theoretical experimental results presented discussed
background autonomic dysfunction implicated range psychological conditions including depression anxiety fragile mental retardation fmr premutation common genetic mutation affects similar women associated psychological vulnerability study examined cardiac indicators autonomic function among women fmr premutation control women potential biomarkers psychological risk may linked fmr methods baseline inter beat interval respiratory sinus arrhythmia measure parasympathetic vagal tone measured women fmr premutation controls women completed anxiety depression questionnaires fmr genetic indices cgg repeat quantitative fmrp fmr mrna activation ratio obtained premutation group results respiratory sinus arrhythmia reduced fmr premutation group relative controls depression symptoms associated reduced respiratory sinus arrhythmia among control women variables unrelated fmr premutation elevated fmr mrna associated higher respiratory sinus arrhythmia conclusions women fmr premutation demonstrated autonomic dysregulation characterized reduced vagal tone unlike patterns observed general population study controls vagal activity depression symptoms decoupled women fmr premutation suggesting independence autonomic regulation psychopathological symptoms atypical potentially specific fmr premutation association vagal tone mrna suggests molecular variation associated fmr plays role autonomic regulation
context data care dtc represents public health strategy using hiv surveillance data link persons living diagnosed hiv infection plwdhi hiv related medical care objective investigate feasibility dtc approach applied partner services program serving geographically diffuse area new york state design disease intervention specialists received training function expanded partner services exps advocates hiv surveillance data identified plwdhi presumed care ooc exps advocates attempted locate reengage ooc individuals hiv related care pilot ran september august setting four upstate new york counties home one third plwdhi upstate new york participants total plwdhi presumed ooc main outcome measures linked hiv medical care cases verified attending hiv medical appointments subsequent case assignment reengaging hiv care hiv laboratory test months following case closure retention hiv care hiv laboratory tests months following case closure results majority assigned cases located located cases confirmed ooc ooc cases successfully relinked care relinkage success differ gender transmission risk major race ethnicity categories however direct relationship age successful relinkage ninety five percent relinked cases reengaged medical care retained care individuals relinked exps advocates likely reengage care individuals interviewed relinked care advocates individuals ineligible exps intervention conclusion dtc effective conducted outside large metropolitan areas closed health care systems also effectively incorporated existing partner services programs however relative priority dtc work must established context
recent advances development sequencing technologies provide researchers unprecedented possibilities genetic analyses review discuss history genetic studies progress driven next generation sequencing ngs using complex inflammatory bowel diseases example focus opportunities also challenges researchers facing working ngs data unravel genetic causes underlying diseases
present research investigates whether spontaneous trait inferences occur conditions characteristic social media networking sites nonextreme ostensibly self generated content simultaneous presentation multiple cues self paced browsing used established measure trait inferences false recognition paradigm direct assessment impressions without asked participants spontaneously formed impressions people whose status updates saw results suggest trait inferences occurred nonextreme self generated content commonly found social media updates experiment nine status updates different people presented parallel experiment although inferences occur free browsing results suggest participants necessarily associate traits corresponding status update authors experiment overall findings suggest spontaneous trait inferences occur social media discuss implications online communication research spontaneous trait inferences
purpose evaluate effects two commercial silicone hydrogel contact lenses cls soaked natamycin fluconazole growth candida albicans vitro eye model methods three printed molds used cast making eye shaped models comprising potato dextrose agar senofilcon lotrafilcon cls incubated either concentration simulate fungal infection eye models coated albicans drug soaked lenses placed top eye models seven experimental conditions examined controlno lens specified time points agar eyes experimental condition removed incubator photographed yeast cells time point also analyzed using light microscopy results considerable growth observed conditions except conditions observed microscope morphology yeast cells condition similar control oval shaped limited hyphae growth observed significant visible hyphae growth group groups cells significantly smaller compared control conclusions limited growth albicans observed eye models even microscope cell morphology differ noticeably testing condition dependent drug lens combinations
study aims compare effects balneological treatments applied consecutive intermittent sessions without interfering daily routine patients knee osteoarthritis randomized controlled single blind clinical trial fifty patients diagnosed knee osteoarthritis included patients divided two groups patients given total ten sessions balneological treatment consisting hydrotherapy mud pack therapy group received consecutive treatment weeks group received intermittent treatment weeks local peloid packs degrees applied min tap water degrees bath evaluations conducted treatment week post treatment pain vas western ontario mcmaster universities osteoarthritis index womac short form balneological treatment regimens knee osteoarthritis statistically significant clinical effects well effects quality life patients well continued months except joint stiffness womac role emotional vitality group mental health groups patient groups improved compared baseline however months treatment well group unable maintained terms role physical parameter well group unable maintained terms pain womac pain physical functions total physical functioning role physical pain role emotional mental health variables compared data obtained immediately treatment study suggests traditional intermittent balneological therapies similar efficacy patients knee osteoarthritis
small emerging contracting companies could possibly flooding construction industry putting strain construction economy stay afloat support sustain participants important organisation deals individuals organisations understand correct ethical codes conduct business environment minimise unethical behaviour industry new contractors need understand apply principles ethical conduct business environments research aimed investigating whether ethical conduct among new entry level emerging contractors contribute ensure sustainable competitiveness south african construction industry research also aimed determining whether education knowledge entrepreneurship business project construction management addition building contracts contribute new entry level emerging contractors ethical conduct sustainable competitiveness literature reviewed results quantitative research among professional consultants south africa formed basis study ethics sensitive topic within construction industry therefore difficult gather data directly contractors reluctant participate fear revealing identities negatively influence personal business credentials unbiased respondents directly linked emerging contractors afraid give objective opinions questioned included architects quantity surveyors consulting engineers project managers construction mentors construction managers study revealed ethics important factor business environment correct application thereof partially contribute sustainable competitiveness new entry level emerging contractors turn promote long term survival business furthermore knowledge good management practices building contracts contribute successfully run business however average new entry level emerging contractor insufficient experience knowledge management construction projects building contracts study valuable construction industry professionals contractors clients provides research information problem area industry
video content stored video event data recorders vedrs used important evidence certain events vehicle collisions occur however sophisticated video editing software assailants easily manipulate video records advantage without leaving visible clues therefore integrity video content recorded vedrs guaranteed number related forensic issues increases existing video integrity detection methods use statistical properties pixels within frame video however methods require ample time check frames individually moreover frame easily replaced forged using appropriate public software solve problem propose integrity checking mechanism using structure ordered fields video file existing video editing software allow users access modify field structures addition proposed method involves checking header information video content much less detection time required compared existing methods examine entire frames store ordered file structure video content signature database using customized automated tool signature appears according video editing software suspected video content compared set signatures file structure matches signature recognize manipulated video file corresponding editing software tested five types video editing software cover video editing software market share furthermore arranged saving options five video editing suites result obtained detection accuracy using stored signatures without false positives collection video files principle method applied video formats elsevier ltd rights reserved
introduction asthma common chronic disease childhood affecting approximately children leading cause hospitalization developed countries paper aimed review evidence chemical pharmacotherapy long term treatment pediatric asthma according latest updates area covered long term treatment essential controlling symptoms reducing future risks including exacerbations decline lung function includes control agents inhaled corticosteroids long acting beta adrenergic agonists leukotriene modifiers recent strategies based use biological drug omalizumab monoclonal antibody directed immunoglobulin ige considered selected patients severe asthma expert opinion near future challenge childhood asthma treatment improve chemical drugs already exist well carefully characterize several different asthma subtypes special regard children severe disease better definition patient features made possible current advanced knowledge pathobiology severe asthma ultimately allow identification specific phenotypes endotypes severe asthma aimed personalize pharmacological treatment
developing new effective therapeutic approach multiple sclerosis always important area research rns bioactive aqueous solution generated subjecting normal saline taylor couette poiseuille flow elevated oxygen pressure recently demonstrated rns administered intraperitoneal injection ameliorated clinical symptoms disease progression experimental allergic encephalomyelitis eae animal model since intravenous route preferred treating chronic condition tested nebulization rns could attenuate disease process adoptively transferred eae mice although could directly image rns nebulization nebulized alexa reached spleen spinal cord different parts brain nebulization rns starting acute phase attenuated clinical symptoms relapsing remitting eae female sjl mice rns nebulization also inhibited perivascular cuffing maintained integrity blood brain blood spinal cord barriers suppressed inflammation normalized expression myelin genes blocked demyelination cns eae mice immunomodulatory front nebulization rns eae mice led enrichment anti autoimmune regulatory cells tregs suppression autoimmune cells together results suggest nebulization rns may used control aberrant immune responses autoimmune disorders
patients essential thrombocythemia often suffer neurological symptoms ever resulting previous thrombotic cerebral events tce reported occurred patients order identify factors influencing related absence tce response therapy overall patients presented reported subjective transient fluctuating without concurrent tce defined related frequency cephalalgia chronic paresthesias dizziness hypotension visual disturbances tinnitus univariate analysis related resulted frequently young people females found higher prevalence jakvf mutation related patients multivariate analysis gender jakvf mutation remained significantly associated development related risk four times higher jakvf mutated patients ninety seven patients related received antiplatelet agent time whereas selected high risk related patients treated cytoreductive drug according published guidelines similarly patients without observed patients related achieved complete response treatment among non responder patients improved introduction cytoreductive therapy therefore addition cytoreductive treatment considered setting
one result globalization rapid growth offshoring outsourcing functions jobs offshore locations usa offshoring progressed point already affects everyday lives cars drive large portion work components outsourced computers typically manufactured offshore shipped back usa electronic diagnostics calls answered overseas phenomenon implications lives jobs engineers scientists assume future something highly developed even lesser developed countries must face consequently growth outsourcing major impact educational objectives engineering programs resultant engineering curricula worldwide paper presents recent data product job offshore migrations discusses various dimensions phenomenon addition potential loss engineering high end technical jobs sociological cultural aspects intellectual property issues strategic planning concerns macro economic issues presented example effects offshoring societal fabric countries recipients manufacturing service center outsourcing china india significant rapid controversial offshoring also begun change way engineering programs countries educate students addition intellectual property issues create major risk companies considering outsourcing certain less developed countries issues broadly categorized robustness strength intellectual property laws degree laws implemented enforced factors currency fluctuations geo political conditions substantially impact outsourcing decisions profitability phenomenon offshoring affecting engineering careers play major role shaping engineering education worldwide next generation engineers need possess ability work seamlessly across cultures outstanding communication skills familiar principles project management logistics systems integration educational models begin address requirements presented elsevier ltd rights reserved
backgroundemotional lability frequent school aged children attention deficit hyperactivity disorder adhd associated frequent comorbidities severe impairment however little research investigated association adhd comorbid symptoms preschoolers study assessed dimensional preschoolers link adhd symptoms hyperactivity impulsivity inattention behavioural emotional problems aggression anxiety methodone hundred fifty four preschoolers aged years old rated questionnaires parents assessed index conners rating scale revised behavioural emotional problems adapted version social behavior questionnaire multiple linear regressions analyses conducted resultshigher associated higher hyperactivity impulsivity inattention anxiety aggression problems controlling behavioural emotional problems sociodemographic variables remained associated hyperactivity impulsivity anxiety conclusionsemotional lability seems potential marker adhd symptoms internalizing problems preschoolers could target diagnosis early interventions finding treated caution study limited low response rate participants consequently small sample size
santiago ramon cajal developed great body scientific research last decade century mainly published manuscripts neuronal theory structure dendrites spines fine microscopic descriptions numerous neural circuits among studies addition numerous cell types neuronal glial described ramon cajal time using reazione nera golgi method among neurons special cells molecular layer neocortex cells also termed cajal cells retzius cells colleagues today cells known cajal retzius cells earliest description several biological aspects fascinating cells analyzed cell morphology physiological properties origin cellular fate putative function cortical development etc review summarize temporal basis emerging knowledge concerning cell population specific attention pioneer studies santiago ramon cajal
purpose review article reviews role neuropeptide npy pathophysiology post traumatic stress disorder ptsd gastrointestinal disorders irritable bowel syndrome ibs ptsd highly comorbid npy low cerebrospinal fluid plasma male combat veterans ptsd correlates negatively sympathetic nervous system sns hyperreactivity ptsd symptoms time recovery npy regulation yet evaluated women ptsd recent findings npy levels bowel tissue low ibs diarrhea ibs versus ibs constipation density ghrelin containing cells gastric oxyntic mucosa markedly increased ibs ptsd relareleaseted sns hyperreactivity may interact substrate increase ghrelin activates receptors lumbosacral spinal cord basolateral amygdala increase colonic motility amygdala hyperreactivity respectively loss function gene polymorphisms adrenergic alpha autoreceptors increased corticotropin releasing hormone observed ptsd also thought contribute ibs summary knowledge shared underlying npy system related neurobiological factors contribute comorbidity ptsd gastrointestinal disorders may help guide research development prescription targeted effective individualized therapeutic interventions
substance use disorders suds adolescence negative long term health effects mitigated successful treatment caregivers play central role adolescent treatment involvement however studies examined treatment motivation pressures enter treatment caregiver adolescent dyads research suggests internally motivated treatment contrast coerced treatment tends lead better outcomes used self determination theory sdt examine intersecting motivational narratives among caregivers adolescents sud treatment relationships motivation interpretation caregiver pressures adolescent autonomy relatedness also explored adolescents sud treatment caregivers dyads interviewed treatment experiences interviews coded treatment motivation including extrinsic motivated punishment introjected motivated guilt identified integrated motivation seeing behavior integral self internalization treatment motivation autonomy support competence caregiver support adolescent decisions relatedness acceptance support also coded four dyadic categories identified agreement treatment motivated adolescent intrinsic agreement treatment motivated caregiver extrinsic agreement treatment motivated shift towards adolescent control mixed transitional disagreement adolescents caregivers claimed motivated treatment conflicting autonomy support relatedness prominent intrinsic dyads least prominent extrinsic dyads mixed transitional group also high autonomy support relatedness extrinsic group characterized caregiver rules unwelcome mechanism behavioral control caregivers groups saw rules way build adolescent competence repair relationships adolescents saw rules indicating care rather control adolescents intrinsic motivations engaged treatment results suggest importance intrinsically motivated treatment highlight autonomy support relatedness mechanisms might facilitate treatment engagement elsevier inc rights reserved
vision based object detection essential multitude robotic applications however also challenging job due diversity environments applications required operate strict constraints apply many robot systems terms run time power space meet special requirements robotic applications propose efficient deep network vision based object detection specifically given image captured robot mount camera first introduce novel proposal layer efficiently generate potential object bounding boxes proposal layer consists efficient line convolutions effective line optimization afterwards construct robust detection layer contains multiple population genetic algorithm based convolutional neural network mpga based cnn module tld based multi frame fusion procedure unlike deep learning based approaches rely gpu line processes system able run efficiently without gpu support perform several experiments validate component proposed object detection approach compare approach recently published state art object detection algorithms widely used datasets experimental results demonstrate proposed network exhibits high efficiency robustness object detection tasks elsevier rights reserved
nowadays cranes widely employed many fields industry utilization represents large financial influence investment cranes example docks mainly associated time required positioning cargos objective experiment develop control system minimize stabilization time load swinging due crane movement using controller created lyapunov function metal structure used pendulum attached linear motor controller designed implemented series experiments done varied conditions mass signal input system moved high speed joystick trigger pressed quickly stabilize pendulum compared traditional methods controlling payload oscillation made evident control method associated use joystick reduce loading time also eliminate need highly experienced driver operating crane authors published elsevier ltd
objective use novel geographic methods large scale claims data identify local distribution pediatric chronic diseases new york city methods using payer emergency claims database identified proportion unique children aged diagnosis codes specific medical psychiatric conditions proof concept compared prevalence estimates traditional health surveys registry data using geographically granular data available addition used home addresses map local variation pediatric disease burden results identified new york city children visited emergency department least though sample included publicly insured uninsured children found moderate strong correlations prevalence estimates compared health surveys registry data prespecified geographic levels strongest correlations found asthma mental health conditions county among younger children respectively moderate correlations neighborhood identified obesity cancer among adolescents correlations health districts strong obesity depression estimates nonsignificant strong negative correlation suicide attempts using satscan also identified local hot spots pediatric chronic disease conclusions conditions easily identified claims data emergency department surveillance may help estimate pediatric chronic disease prevalence higher geographic resolution studies needed investigate limitations methods assess reliability local disease estimates
drastic urbanization taken place china last two decades recently considerable number ghost cities emerged due extensive unreasonable urban expansion far exceeds practical demand order investigate ghost cities proposed feasible framework utilizing multi source remote sensing datasets including nighttime light imagery land cover type products population grid eliminating blooming effect nighttime imagery proposed modified optimal threshold method motm extracting built area land cover type products developed ghost city index gci quantify evaluate intensity ghost city phenomenon yangtze river delta county district level gci established according intrinsic features ghost cities comprising three criteria consistency lit area built area illumination intensity population density explored spatial pattern ghost cities different gci categories ternary contour applied demonstrate key factor among three criteria finding implies ghost cities prominently spatial clustered meanwhile counties new development zones higher risk suffering phenomenon capital cities municipal cities alleviative effect ambient regions besides regions higher intensity phenomenon tend less balanced composition among three criteria results show good consistency previous reports studies providing objective spatial explicit insight ghost city phenomenon findings prove capability monitoring ghost cities using remote sensing data would also beneficial urban planning regional sustainable development elsevier ltd rights reserved
properly selected electric motor fitted power envelope could respond electric vehicle needs avoid overdesign paper proposes iterative algorithm upon designers could define proper motor evaluate impact total mass reduction simplify design two characteristics recognized essential enhance namely constant power speed range cpsr overall efficiency selected driving cycles full battery powered three wheel roadster prototype motor analyzed another sample motor higher cpsr proposed remove part powertrain overdesign limited test data inverse distance weighted interpolation applied extract efficiency electric motor operating point finally based overdesign total efficiency comparison two motors made
semantic dementia behavioral variant frontotemporal dementia bvftd subtypes frontotemporal dementia characterized distinct clinical symptoms neuroimaging features predominant left temporal grey matter atrophy bilateral right frontal atrophy bvftd differential hemispheric predilection may also reflected neuroimaging features brain connectivity study investigated white matter microstructure functional connectivity differences bvftd focusing hemispheric predilection differences eight bvftd patients controls underwent diffusion tensor imaging resting state functional mri whole brain microstructure assessed determine distinct tracts affected bvftd tracts diffusivity measures lateralization indices calculated functional connectivity established regions affected early stage bvftd results direct comparison bvftd reported whole brain microstructure abnormalities pronounced left hemisphere bilaterally slight predilection right bvftd lateralization tract specific abnormalities seen toward left hemisphere functional connectivity disease specific regions mainly decreased bilaterally right hemisphere bvftd bvftd show microstructure functional connectivity abnormalities different regions respectively pronounced left hemisphere right hemisphere bvftd indicates differential hemispheric predilection brain connectivity abnormalities bvftd
background degree liver fibrosis non alcoholic fatty liver disease nafld critical predictive factor patient prognosis study intended perform external validation various fibrosis prediction models assessing advanced fibrosis korean nafld patients methods retrospective study patients nafld confirmed liver biopsy hospitals affiliated koran nafld study group conducted predictive ability existing liver fibrosis prediction models including nafld fibrosis score nfs bard fibrosis compared results among samples liver slides suitable evaluation advanced fibrosis present patient samples univariate analysis found group advanced fibrosis showed low alanine aminotransferase values high aspartate aminotransferase alanine aminotransferase ratios well high incidence diabetes however multivariate analysis showed presence diabetes triglycerides independent risk factors receiver operating characteristic nfs fibrosis bard model nfs found best predicting advanced fibrosis among three prediction models negative predictive value predicts advanced fibrosis using low cutoff applied nfs conclusion negative predictive value using low cutoff value high positive predictive value using high cutoff value low korean nafld cohort using nfs
background context short term readmission rates becoming widely used quality performance metric hospitals data unplanned short term readmission spine fusion deformity pediatric patients limited purpose characterize rate risk factors short term readmission spine fusion deformity pediatric patients study design retrospective cohort study patient sample data obtained state inpatient database newyork utah nebraska florida north carolina years california years outcome measures outcome measures included day readmission rates materials methods inclusion criteria patients aged years primary diagnosis spine deformity primary level lumbar thoracic fusion exclusion criteria included revision surgery index admission cervical fusion readmission rates calculated logistic analyses used identify independent predictors readmission results total patients median age years sixty seven percent girls overall day readmission rates common reasons readmission infection days days wound dehiscence pulmonary complications multivariate analysis predictors day readmission included male sex neuromuscular congenital scoliosis scheuermann kyphosis medicaid insurance length stay days operations year associated reduced risk day readmission confidence interval compared hospitals performing operations year conclusions short term readmission rate pediatric spine deformity surgery driven patient related factors well several risk factors may modified reduce rate elsevier inc rights reserved
article proposes reflection impact postmodern features sense identity mental functioning propose possible explanations identity changes new forms psychopathology revisiting recent literature theme study proposes clinical consideration possible link new forms psychopathology mental suffering particularly suggests changes observed affectivity including increase dysphoria irritability restlessness boredom feeling empti ness behaviour reduction impulse control ability interpersonal skills reflective function etc important indices bigger change involves entire personality indicates shifting towards borderline level personality functioning finally article offers possible explanation shift advances therapeutic questions
mechanisms underlying bupropion efficacy antidepressant smoking cessation aid far fully characterized present study first examine effects bupropion visuospatial task related parietal eeg alpha power asymmetry asymmetry previously found associated severity depressive symptoms depressive symptoms greater alpha power right left parietal area henriques davidson rabe debener brocke beauducel participants smokers none clinically depressed randomly assigned placebo group bupropion group double blind study eeg performance visuospatial task collected days placebo bupropion sustained release capsules relative placebo group bupropion group especially bupropion subgroup positive right versus left parietal alpha power asymmetry pretreatment reduction parietal alpha asymmetry driven largely decrease right parietal alpha power findings support hypothesis bupropion induce changes parietal eeg asymmetry shown previous literature associated reduction depressive states traits
background incidence pregnancy advanced age among women increasing availability assisted reproduction although long term health consequences known objective purpose study determine effect pregnancy advanced age occurrence cardiovascular events large cohort postmenopausal women study design analyzed data women aged years enrolled observational arm women health initiative study determined effect pregnancy advanced age last pregnancy age year risk ischemic stroke hemorrhagic stroke myocardial infarction cardiovascular death mean period standard deviation years using cox proportional hazards analysis adjusting potential confounders results total participants reported pregnancy advanced age compared pregnancy normal age rates ischemic stroke hemorrhagic stroke cardiovascular death significantly higher among women pregnancy advanced age multivariate analysis women pregnancy advanced age likely experience hemorrhagic stroke hazard ratio confidence interval adjustment age race ethnicity congestive heart failure systolic blood pressure atrial fibrillation alcohol use cigarette smoking significant difference risk ischemic stroke myocardial infarction cardiovascular death among women pregnancy advanced age adjustment potential confounders conclusion women pregnancy advanced age higher risk hemorrhagic stroke postmenopausal period
background detection mutated epidermal growth factor receptor egfr non small cell lung cancer nsclc residual cell pellets derived liquid based cytology lbc samples endoscopic ultrasound guided fine needle aspiration validated allele specific polymerase chain reaction aim study validate next generation sequencing ngs technology detecting gene mutations residual cell pellets lbc methods archived dna extracted lbc samples adenocarcinoma stored preservcyt known egfr mutation status retrieved genomic dna multiplex amplified enriched ion ampliseq cancer hotspot panel chemistry onetouch instrument followed semiconductor sequencing ion personal genome machine platform mutation hotspots nsclc related genes braf egfr erbb kras met phosphatidylinositol bisphosphate kinase catalytic subunit pikca analyzed nextgene torrent suite bioinformatics tools results commonly identified egfr sequence changes including mutations exon deletions exon insertion concordance assay platforms less common nsclc variants also found mutation hotspots erbb kras met pikca genes conclusions nsclc mutation analysis using ngs successfully performed residual cell pellets derived lbc samples approach allows simultaneous examination multiple mutation hotspots timely manner improve patient care american cancer society
purpose current work shows approach solve quality service qos multicast routing problem using particle swarm optimization pso problem finding route source node multiple destination nodes multicast minimum cost complete problem steiner tree problem even greater qos constraints taken account thus approximation algorithms necessary solve problem purpose paper present routing algorithm two qos constraints delay delay variation solving routing problem based modified version pso design methodology approach work involved following methodology literature review routing algorithm design implementation designed routing algorithm java programming simulations results findings work authors compared routing algorithm exhaustive search approach results showed algorithm improves execution times percent different topologies research limitations implications algorithm tested three different topologies nodes dense graph topology originality value algorithm implements novel technique fine tuning parameters implemented bio inspired model pso using genetic meta optimizer authors also present simple multi implementation approach using encoding system fits multiple bio inspired models
article examines psychological characteristics children interpersonal interaction childhood youth age building interpersonal relationships significant condition development personality different age periods essential opportunities development formed time children staying recreational institutions adolescence interpersonal interaction great influence formation personality adolescent learns principles collaboration mutual help risk sake means interpersonal interaction communication adolescents becomes deeper meaningful forms interaction friendship love emerge master gender roles social standards values help period interpersonal interaction following three forms intimate personal spontaneous group socially focused result empirical research peculiarities adolescents interpersonal interaction means technique sort testing technique stephenson determined method made possible focus behavioural tendencies adolescent group dependence independence sociability unsociability taking struggle avoiding struggle consideration tendencies provides opportunity educators improve interpersonal interaction adolescents recreational period create conditions correction negative manifestations determination personal grounds interaction helps provide personal approach educational work aimed development adolescents communication sphere tendencies sociability independence contribute interpersonal interaction taking struggle avoiding struggle either improve worsen depending situation people involved adolescents successfully interacting one another characterized sociable kind emotionally stable self confident independent brave etc unsuccessful adolescents described shy indecisive dependent group anxious
channels read front end lhc atlas muon drift tubes detectors presented xafe system composed cascade analog signal processing front end wilkinson perform voltage time conversion time threshold detection sensitivity output analog signal processing chain equivalent noise charge enc similar performing preamplifier rise time performances achieved managing high detector parasitic capacitance front end input similar channel consumes single supply voltage cmos total area occupancy
investigate nonlinear aerostatic stability hutong cable stayed rail cum road bridge ultra kilometer main span fem bridge model established tri component wind loads geometric nonlinearity taken consideration discussed influence nonlinear parameters factors bridge resistant capacity aerostatic instability results show effect initial wind attack angle significant aerostatic stability analysis bridge geometric nonlinearities bridge considerable importance analysis especially effect cable sag instable mechanism hutong bridge steel truss girder spatial combination vertical bending torsion large lateral bending displacement design wind velocity much lower static instability wind velocity structural aerostatic resistance capacity meet requirement
industrial manufacturers required adopt water conservation pollution control technologies increasingly serious water scarcity water pollution especially textile industry effective performance evaluation tool technologies greatly needed textile manufacturers however existing tools textile industry evaluate plant level ignore pollution effect water consumption order help textile manufacturers know water conservation pollution control performance technologies systematically comprehensively developed process level water conservation pollution control performance evaluation tool cleaner production technology textile industry new tool includes three indicators water withdrawal reduction water consumption reduction water assimilation reduction comparison new tool old ones evaluating low pollution concentration effluent reuse technology polyester flannel fabric dyeing printing plant demonstrates new tool help textile manufacturers understand operation mechanism technology specific processes take specific improvement measures different processes optimize water conservation pollution control performance also find indiscoverable disadvantages technology adopt complementary technologies reduce negative effect technology elsevier ltd rights reserved
week course designed funding society manufacturing engineers sme input industry representatives offer upper division engineering students course advanced automation objective provide engineering students theoretical hands practical experience automation technologies prime importance next decade data acquisition instrumentation machine vision motion control paper describes machine vision portion class describes important concepts hands equipment labs developed course well examples student projects spring quarter course laboratory materials evaluated learning effectiveness technical content included paper
background higher levels parental stress long term effects children health could lead dysfunction parent child interaction different background factors predictors high parental stress aim aim study examine parental stress among swedish women identify different factors linked women parental stress method women recruited clinical study followed six months birth data collected two questionnaires women completed swedish parental stress questionnaire spsq findings less good mental health depressive symptoms birth strongly associated parental stress strongest association found post partum depressive symptoms high levels stress subscale incompetence multiparity associated high stress two subscales lower level education protective factor stress nearly subscales conclusions depressive symptoms perceived poor mental health post partum important factors related high parental stress results point importance identifying supporting mothers depressive symptoms since women mental illness increased stress
persistent debate define episodic memory whether uniquely human capacity one hand many animal cognition studies employ content based criteria criterion argue nonhuman animals possess episodic memory hand many human cognition studies emphasize subjective experience retrieval essential property episodic memory distinctly human foresight purportedly enables propose perspectives may examine distinct complementary aspects episodic memory drawing conceptual distinction episodic memory traces mental time travel episodic memory traces sequential mnemonic representations particular personally experienced episodes mental time travel draws traces requires components construct scenarios embed larger narratives various nonhuman animals may store episodic memory traces yet possible humans able construct reflect narratives lives flexibly compare alternative scenarios remote future elsevier ltd rights reserved
current university degrees focused promoting autonomous learning student respect active learning methodologies general technological resources particular play fundamental role process alongside providing undeniable support teaching endeavours aim paper describe set tools computer simulation called virtual laboratories specifically developed support teaching learning related subjects elasticity strength materials subjects ubiquitous many degrees engineering architecture virtual laboratories allow simulating many problems case studies user interface simple direct way teaching learning tools facilitate assimilation underlying concepts every simulation performed virtual laboratories offer ease use great interactivity graphical output authors aforementioned tools multidisciplinary group lecturers departments continuum mechanics theory structures applied mathematics applied physics universitat politecnica valencia experience joint work also constitutes ideal framework cross departmental collaboration turn contributes vertebrate contents engineering degree virtual laboratories available institutional repository riunet universitat politscnica valencia enables access students subject terminal connected network institution intended future increase number virtual laboratories order cover maximum possible number aspects referred subjects furthermore collection opinions users allow feedback process consequent improvement tools
child maltreatment demonstrated many short long term harmful consequences victims whether child abuse associated increased risk peer victimization adolescence unclear study analyzed prospective data children parents participating longitudinal studies child abuse neglect longscan investigate relationships child physical sexual abuse adolescent victimization peers well potential gender moderate relationships results ordinal logit regression models indicated children physically abused prior age based official reports parent reports child reports greater risk experiencing intimidation physical assault peers age history sexual abuse predicted physical assault intimidation evidence gender moderated relationships cases relationship abuse revictimization similar boys girls findings emphasize need provide victims abuse assistance help prevent cycle victimization elsevier ltd rights reserved
quantum key distribution qkd promises unconditionally secure communications however low bit rate qkd meet requirements high speed applications despite many solutions proposed recent years neither efficient generate secret keys compatible qkd systems paper based chaotic cryptography middleware technology proposes efficient universal qkd protocol directly deployed top existing qkd system without modifying underlying qkd protocol optical platform initially takes bit string generated qkd system input periodically updates chaotic system efficiently outputs bit sequences theoretical analysis simulation results demonstrate protocol efficiently increase bit rate qkd system well securely generate bit sequences perfect statistical properties compared existing methods protocol efficient universal rapidly deployed qkd system increase bit rate qkd system becomes bottleneck communication system
top priority medical institutions provide quality patient care services considering healthcare personnel work colleagues various cultures important medical personnel training service training improvement professional knowledge skills ability adapt working diverse team planning employee training service training based strategic targets personnel training needs institution qualification support programmes organised medical personnel improve professional knowledge knowledge skills medical nurses areas primarily related patient care lack training stress management development stress resistance well facilitation collaboration individuals various cultures aim research study assess work stress levels healthcare personnel applied work stress management strategies levels social psychological adaptation personnel ability adapt cultural diversity mutual correlations research questions levels work stress healthcare personnel work stress management strategies applied healthcare personnel levels social psychological adaption healthcare personnel ability healthcare personnel adapt cultural diversity statistically significant correlations personnel work stress applied work stress management strategies levels social psychological adaptation ability adapt cultural diversity personnel exactly included personnel training plan preparing personnel work multicultural environment respondents research study healthcare personnel carrying duties latvia scandinavia simultaneously following surveys used data collection work stress scale stress management survey survey regarding social psychological adaptation cultural diversity self evaluation survey results research study suggest respondents low levels work stress active pro social management strategies frequently used manage stress social psychological adaptation score corresponds medium level result research study authors prepared recommendations human resources department regarding organisation training stress management development stress resistance well fundamentals collaboration individuals various cultures order improve professional personal competences
chromosomal microarray analysis cma unexplained anomalies developmental delay improved diagnosis rates results classified variants uncertain significance vus may challenge clinicians families explored impact results families including parental knowledge understanding interpretation semi structured telephone interviews conducted parents received genetic counseling vus child transcripts analyzed iterative coding process participants demonstrated range recall personal interpretation regarding whether test results provided causal explanation children health issues participants maintained contradictory interpretations describing results answers maintaining little clarification child condition provided reported benefits included obtaining medical services personal validation parents described adaptation coping processes similar occurring positive test results recall terminology including vus precise cma abnormalities poor however demonstrated conceptual understanding scientific uncertainty participants expressed intentions return recommended genetics follow misconceptions would occur results provide insight patient family experience receiving uncertain genomic findings emphasize importance exploring uncertainty communication process highlight areas potential attention improvement clinical encounter
background preservatives added cosmetics consumer products prevent microbial growth product degradation many cosmetic preservatives skin sensitizers frequent causes contact dermatitis use preservatives may vary country region according legislation may reflected differences prevalence rates preservative allergy worldwide objective examine type frequency preservative use cosmetics sold thai markets metropolitan bangkok thailand methods preservatives contained different cosmetics sold thai markets documented analysed based labelling ingredients results cosmetic skincare products sold thai markets international brands small proportion cosmetic products produced thailand international brand cosmetics likely contain non formaldehyde releasing preservatives domestically produced brands isothiazolinone based preservatives responsible current increase prevalence contact allergy found significant frequency domestically produced leave cosmetic products conclusion preservatives cosmetics significantly different according source production type cosmetics
cloud radio access network cloud ran recently proposed one cost effective energy efficient techniques wireless networks moving signal processing functionality single baseband unit bbu pool centralized signal processing resource allocation enabled cloud ran thereby providing promise improving energy efficiency via effective network adaptation interference management paper propose holistic sparse optimization framework design green cloud ran taking consideration power consumption fronthaul links multicast services well user admission control specifically first identify sparsity structures solutions network power minimization user admission control problems call adaptive remote radio head rrh selection user admission however finding optimal sparsity structures turns hard coupled challenges norm based objective functions nonconvex quadratic qos constraints due multicast beamforming contrast previous works convex nonsmooth sparsity inducing approaches group sparse beamforming algorithm based mixed norm relaxation adopt nonconvex smoothed minimization approach promote sparsity multicast setting thereby enabling efficient algorithm design based principle majorization minimization algorithm semidefinite relaxation sdr technique particular iterative reweighted algorithm developed converge karush kuhn tucker kkt point relaxed smoothed minimization problem sdr technique illustrate effectiveness proposed algorithms extensive simulations network power minimization user admission control multicast cloud ran
traditional black box optimization searches set potential solutions optimizing value function whose analytical algebraic form unknown inexistent whose value queried input optimization generalization setting fully evaluating potential solution may require querying function typically large number times case optimization poses unique difficulties designing assessing algorithms generally applicable approach judge optimization algorithm performance via aggregate possible functions problem domain establish formal definitions aggregate performance investigate following questions concerning algorithm design algorithms strictly better others free lunch optimal algorithms exist practical formally define free lunch aggregate optimality optimization algorithms derive generic conditions existence review explain prior free lunch results perspective conditions also show framework used bridge several fields research allowing formalization various problems views performance apply extend generic results context involving particular type optimization called worst case optimization context show exist algorithms aggregately optimal budget allowed number function calls starting point set previously uncovered function call outcomes also non trivially strictly optimal many budgets starting points moreover formalize operation optimal algorithms show certain domains budgets starting points operation equivalent simple procedure tractable implementation first kind result optimization authors published elsevier
effective approach early intervention children families including child maltreatment prevention home based services although several evidence based programs exist often grouped delivered together despite different foci approaches article describes development pilot phases trial evaluating systematic braiding evidence based home based models safecare parents teachers describe methodology braiding model implementation curriculum specifically focusing structured qualitative feedback pilot families providers used create braided curriculum implementation systematic braiding models implementation curriculum levels mechanism potential meet comprehensive needs families risk maltreatment
background thrombotembolic complications leading cause mortality essential thrombocythemia definition thrombotic risk remains far clear objectives aim study evaluate prognostic markers thrombosis identify patients risk material methods forty five consecutive patients studied group divided two subgroups patients without history thrombosis patient tested complete blood count fibrinogen factor viii dimer protein apcr tat jak mutation assessed pcr factor leiden prothrombin genes mutations screened dna sequencing results median age patients years jak mutation found patients history thrombotic events jak positive compared controls patients significantly higher wbc plt counts higher mean platelet volume mpv hgb level rbc count subgroup apart changes seen whole hgb level rbc count hct also significantly elevated interestingly mpv significantly larger subgroup fibrinogen dimers levels significantly higher group controls tat results hemostatic tests markedly differ subgroups apcr found patients factor leiden heterozygous mutation prothrombin gene mutation observed conclusions results suggest mpv serve simple test assessing hypercoagulable state patients confirmed jak mutation leukocytosis independent predictors thrombotic events patients
osteoarthritis marker degeneration within skeleton frequently associated age study quantifies correlation age death investigates utility shoulder forensic age indicator using modern north american sample individuals lipping surface porosity osteophyte formation eburnation percentage joint surface affected recorded ordinal scale summed create composite scores assigned specific phase spearman correlation indicated positive relationship composite score age right shoulder left shoulder transition analysis revealed tendency toward earlier degeneration right shoulder bayesian statistics generated phase related age estimates based highest posterior density regions best age estimates seventh decade percentile proposed method supplements traditional techniques providing age estimates beyond homogenous age cohort
objective study examined sustained efficacy media violence intervention reducing media violence use normative acceptance aggression aggressive behavior adolescents used experimental design evaluate effects intervention period months method german graders assigned week school based intervention reduce media violence use intervention control group media violence use normative acceptance aggression aggressive behavior measured months intervention months post intervention follow ups months intervention article focuses findings follow ups results controlling baseline levels various demographic covariates media violence use self reported physical aggression significantly lower intervention group indirect path intervention aggression via media violence use significant lower media violence use predicted lower normative acceptance aggression among participants lower initial aggression effects nonviolent media use relational aggression observed conclusion findings show short class based intervention produce lasting changes media violence use linked decrease aggression
self determination theory introduces multidimensional view motivation explains different types motivation promoted hindered following gagne purpose study create abbreviated version multidimensional work motivation scale mwms study psychometric properties instrument using data workers three mediterranean countries greece italy spain factorial analyses indicated item scale factor structure across three mediterranean languages reflecting common cultural idiosyncrasies influences convergent discriminant validity indicated intrinsic integrated forms autonomous motivation positive relationship job satisfaction affective normative commitment prosocial behavior perceived organizational support job autonomy leader member exchange controlled forms motivation social material unrelated negatively related variables examined exception continuance commitment positive association lastly amotivation negatively related employee related variables except continuance commitment practical implications suggestions development future research based self determination theory discussed
transition adolescents chronic conditions challenging task study aimed explore experiences needs adolescents chronic conditions transition period apply findings design generic patient education programme data collected sample adolescents chronic conditions northern germany switzerland including broad range views due variation disease management organisation care paediatric adult populations participants interviewed group individual interviews september february data analysed using qualitative content analysis findings revealed interviewees expressed high levels competency management chronic conditions identified gaps healthcare unmet needs transition particular believed would benefit opportunities exchange ideas specific information peers vocational medical issues concerning adolescent health identified themes reflecting adolescent needs used develop transition workshop including modules regarding following transfer adult medicine new role patient orientation within healthcare system vocational issues detachment parents social support contraception substance abuse family planning stress management activation resources developing personal goals workshop content largely generic included condition specific components workshop designed compact day patient education programme group setting adolescents prior transfer adult care guiding principle idea empowerment supporting adolescents various interactive methods develop adequate knowledge skills understanding motivation regarding chronic conditions conclude patient education programmes promoting adolescent self management empowerment increase preparedness transition
paper reports design development evaluation framework implements virtual humans information provision framework used create interactive multimedia information visualizations images text audio videos models provides dynamic data modeling mechanism storage retrieval implements communication multimodal interaction techniques interaction may involve human agent agent environment agent agent communication framework supports alternative roles virtual agents may act assistants existing systems standalone applications even integral parts emerging smart environments finally evaluation study conducted participation people study developed system terms usability effectiveness employed assisting mechanism another application evaluation results highly positive promising confirming system usability encouraging research area
social information processing sip theory parenting risk posits social cognitive neuro cognitive incapacities characterize risk parents cognitive difficulties operate across relational domains study focused highly disadvantaged mothers preschoolers compared mothers histories perpetrating child neglect demographically similar mothers without histories participants completed measures unrealistic expectations children adults social problem solving parenting nonparenting situations executive functioning attributions children adults predicted associations among measures found within across relational domains exploratory factor analysis revealed two distinct clusters distinguished two groups first included measures expectations attributions children adults second included problem solving difficulties group differences examined individual variables mothers histories perpetrating neglect exhibited unrealistic expectations children adults hostile attributions toward children adults poorer performance tests comparisons interpersonal problem solving parenting nonparenting situations failed differentiate neglect group comparisons regression analyses parenting nonparenting social cognition contributed significantly child neglect findings provide support cognitive model parenting risk suggest widespread disturbances parenting nonparenting social cognition neurocognition may play role child neglect
although previous studies inmates forensic psychiatric samples suggest relation childhood trauma suicide behavior well childhood trauma violent delinquency understanding possible underlying mechanisms still fragmentary naturalistic study design tested suicidal attempts violent crimes differently associated adverse childhood experiences levels appetitive aggression male forensic psychiatry inpatients adverse childhood experiences appetitive aggression styles collected means self report measures suicide attempts taken medical history violent crimes appraised official court records data analyzed means generalized linear models results revealed appetitive aggression adverse childhood experiences significant predictors suicide attempts whereas violent crimes associated solely appetitive aggression suicide attempts violent delinquency forensic patients seem positively associated high levels appetitive aggression whereas etiological pathways might differ regard adverse childhood experiences considering interrelations greater extent might improve diagnostics treatment forensic patients elsevier ireland ltd rights reserved
introduction estimating national prevalence child sexual abuse csa association health developmental outcomes first step developing prevention strategies data available many countries less known epidemiology csa japan methods systematic review searched english databases embase ovid medline process non indexed citations ovid medline daily ovid medline ovid oldmedline psycinfo japanese databases cinii stage children rainbow center japan japan child family research institute japanese journal child abuse neglect identify articles published july examining lifetime prevalence csa japan using non clinical samples data extracted published reports results initially identified citations abstract review retrieved publications six studies met selection criteria additional two relevant studies reviewed range contact csa females prevalence type csa males range penetrative csa females males number methodological issues identified including lack validated measures csa low response rates conclusion contrast lower prevalence penetrative csa prevalence contact csa among japanese females may comparable higher relation international estimates future research children perceptions exposure sexual abuse crime exploitation japan discussed elsevier ltd rights reserved
inflammatory chronic structural changes objective signs axial spondyloarthritis sacroiliac joints sijs inflammation sacroiliitis visualized bone marrow edema whereas chronic structural changes visualized fat metaplasia erosions sclerosis ankylosis area sij spine bone marrow edema vertebral bodies represents spondylitis also affect facet costovertebral costotransverse joints arthritis whereas structural changes visualized fat metaplasia sclerosis syndesmophytes ankylosis vertebral edges
multiple sclerosis disease recognize destruction myelin around nerve cells brain spinal cord called oligodendrocytes genetic environmental factors play roles one genes killer cell immunoglobulin like receptor kir expressed surface natural killer cells nks genes loci locus human genome inherit haplotypes results previous studies show different genes kir may affect susceptibility resistance autoimmune disorders pathogenesis still unclear since nks play key roles immune tolerance intend perform meta analysis correlation kir genes used software comprehensive meta analysis data totally patients controls among genes kir human genome lack kirds accompanied kir gene found risk factor studies molecules nks like nkga suggested authors published elsevier inc
direct self injurious behavior dsib become important focus due perniciousness perplexity little known prevalence correlative factors chinese adolescents including data may differ according gender multicenter multistage stratified cluster random sampling used examine previous month prevalence dsib well possible correlates demographics risky behaviors suicidality psychosocial factors associated dsib school based sample students boys girls approximately adolescents sample reported least one incident dsib past month period controlling demographic variables analyses independent relationships dsib risky behaviors suicidality psychosocial factors conducted gender smoking binge drinking running away home suicide ideation suicide plans positive affect physical symptoms identified common factors associated dsib genders final model addition truancy fighting physical inactivity motor impulsiveness depressed affect found related dsib boys whereas suicide attempts somatic complaints found related dsib girls separation anxiety social anxiety associated negatively dsib boys girls respectively dsib found independently relate attention impulsiveness non planned impulsiveness self esteem harm avoidance either genders dsib prevalent chinese adolescents programs intended promote physical mental health adolescents take account gender differences dsib associated factors including risky behaviors suicidality psychosocial factors
sparse representations proven efficiency solving wide class inverse problems encountered signal image processing conversely enforcing information spread uniformly representation coefficients exhibits relevant properties various applications robust encoding digital communications antisparse regularization naturally expressed infinity norm penalty paper derives probabilistic formulation representations anew probability distribution referred democratic prior first introduced main properties well three random variate generators distribution derived probability distribution used prior promote antisparsity gaussian linearmodel yielding fully bayesian formulation antisparse coding two markov chain monte carlo algorithms proposed generate samples according posterior distribution first one standard gibbs sampler second one uses metropolis hastings moves exploit proximity mapping log posterior distribution samples used approximate maximum posteriori minimum mean square error estimators parameters hyperparameters simulations synthetic data illustrate performances two proposed samplers complete complete dictionaries results compared recent deterministic variational fitra algorithm
work performed time resolved micro photoluminescence trpl studies cuznsns czts single crystals grown molten salt order disorder degree czts varied thermal post treatment temperature photoluminescence spectra measured showed asymmetric band peak position partially ordered disordered structures respectively thermal activation energies found mev partially ordered mev partially disordered low activation energy values indicating defect cluster recombination model partially ordered disordered structures trpl measured crystals decay curves fitted stretched exponential function order describe charge carriers recombination dynamics low temperature
open circle sea water hydraulics utilizing surrounding water working medium become popular submersible axial piston pump port valves used frequently open circle water hydraulic system port valve one important parts type pump however literatures effect port valves materials noise characteristic water pump study effect materials noise pump researched experimental theory simulation methods influences three kinds plastics polyetheretherketone peek polytetrafluoroethylene ptfe aliphatic polyamides nylon one kind anti corrosion stainless steel colimared noise pump different materials port valve seat ranges high low order nylon peek ptfe differences would contribute collision valve spool seat identified simulating results experimental results showed difference noise peek ptfe small addition lifespan volumetric efficiency also taken considering peek selected use seawater pump large submersible
background discovery novel photoreceptor retinal ganglion cells highest sensitivity blue light led research effects short wavelength light humans several studies explored efficacy monochromatic blue blue enriched light treatment sad study comparison made effects broad wavelength light without ultraviolet wavelengths compared narrow band blue light treatment sub syndromal seasonal affective disorder sub sad method day design participants suffering sub sad completed minute sessions light treatment five consecutive days participants given bright white light treatment blt broad wavelength light without lux irradiance watt participants received narrow band blue light blue lux irradiance watt participants completed daily weekly questionnaires concerning mood activation sleep quality sleepiness energy also mood energy levels assessed means sigh sad primary outcome measure results day sigh sad ratings significantly lower day blt effect size blue effect size statistically significant differences found main outcome measures conclusion light treatment effective treatment sub sad use narrow band blue light treatment equally effective bright white light treatment
datura metel solanaceae annual herb widely used traditional medicine treatment coughs bronchial asthma rheumatism chemical investigation acidic methanol extract whole plants metel resulted isolation five new steroidal saponins named metelosides four known compounds structures elucidated extensive spectroscopic methods including nmr spectra structures metelosides found unusual among reported spirostane type steroidal saponins due presence acetamide groups molecules compounds shown cytotoxic three cancer cell lines including hepg mcf mel cells furthermore compounds exhibited modest anti inflammatory effects inhibition production lps stimulated cells elsevier inc rights reserved
portable tester accessing human skin status quantitatively home reported interdigital electrode ide contacts directly human skin used sensing element electrode skin model simplified resistance capacitance series using square wave signal excitation impedance ide measured charging discharging way one measurement cycle response voltages two excitation frequencies khz measured successively equivalent resistance capacitance skin resolved measured values numerical experimental simulation results indicate proposed circuit corresponding algorithms work well resistors capacitors performance tester experimentally tested human skin cases different status obvious relationship measured values skin status observed moreover distinctive results obtained hydrating emollient cosmetics smeared skins tester potentially used give quantitative guidance individual skin care cosmetics selection
clinical preclinical studies indicated chronic methamphetamine use associated extensive neurodegeneration psychosis cognitive impairment evidence animal models suggested considerable role excess dopamine glutamate oxidative stress neuroinflammation apoptosis induced neurotoxicity protein kinase delta might mediate interaction among factors addition relatively long lasting recurrent nature psychosis reproduced animals treated various dosing regimens shown behavioral sensitization sociability deficits impaired prepulse inhibition genetic predisposition well dopaminergic glutamatergic alterations might important development psychosis neuroimaging studies identified functional morphological changes related cognitive dysfunction shown chronic users failure task evoked phosphorylation extracellular signal related kinase likely underlies induced memory impairment recent progress suggested certain roles oxidative stress neuroinflammation psychosis cognitive deficits induced repeated low doses review provides comprehensive description pertinent findings human animal studies emphasis current understanding underlying mechanisms neuropsychotoxicity relevance parkinson disease schizophrenia
development therapeutic antibodies represents revolutionary change medical therapy digestive diseases beginning initial studies confirmed pathogenicity cytokines inflammatory bowel disease development application therapeutic antibodies brought challenges insights potential optimal use infliximab first biological drug approved use crohn disease ulcerative colitis lessons learned infliximab include importance immunogenicity influence pharmacokinetics disease response outcomes building foundation therapeutic antibodies achieved approval inflammatory bowel disease many development several digestive diseases review reflect history therapeutic antibodies discuss current practice future directions field
assess standard dose hormone therapy bone mass premature ovarian insufficiency poi women poi using standard estrogen dose women without evaluated underwent bone mineral density bmd evaluation lumbar spine total femur mean age age last period body mass index bmi untreated groups years years respectively women taking standard dose started treatment age years hormone treatment years time bone densitometry examination bmd bmd respectively untreated groups altered bmd osteopenia osteoporosis verified women without treatment using standard dose bmd altered without users conclusion standard dose adequate reduce impaired bone mass spine femur women poi
documentation severity disease patients spondyloarthritis spa represent clinical challenge especially course spa different patients spa often complain symptoms pain fatigue stiffness well limitations mental functions social participation wide range functional impairments could far insufficiently documented one single measurement instrument despite various attempts recent years experts could reach agreement definition severity documentation extent severity starting point development asas health index presented initially focused patients ankylosing spondylitis questionnaire serves document health functional ability patients available since original english version asas health index together accompanying environmental factors set article describes german translation transcultural adaptation asas health index accompanying environmental factors set
although providing care family member friend may provide psychological benefits informal unpaid caregivers also encounter difficulties may negatively affect quality life well mental physical health loneliness one important challenge caregivers face psychological state associated morbidity premature mortality although previous research identified loneliness issue associated informal caregiver paucity evidence attempts understand phenomenon depth study aimed examine informal caregivers reflections accounts experiences loneliness linked caregiving situation part cross sectional qualitative study sixteen semi structured interviews conducted spousal caregivers daughters caring parent mothers caring child children woman looking partner cared persons suffering range mental physical health conditions dementia frailty due old age multiple sclerosis depression autism data analyzed using inductive thematic analysis experiences loneliness described reference context shrunken personal space diminished social interaction caused restrictions imposed caregiving role loneliness also articulated background relational deprivations losses well sentiments powerlessness helplessness sense sole responsibility social encounters also seen generate loneliness characterized form distancing though sources circumstances loneliness caregivers amenable change opportunities respite care services well heightened sensibility social appreciation caregivers valued contributions could help caregivers manage forms loneliness
smart material reinforced non destructive structural health monitoring technique evolving predominated route assessing performance civil structures present study multiwalled nanotubes mwnt suitably incorporated cement matrix act actively embedded sensor monitoring real time flaws structures initially stable homogenous mwnt dispersion prepared using ionic surfactant technique high intensity ultrasonic agitation process since suitable adequate synthesis procedure incorporate mwnt cement matrix essential complicated role amplitude frequency sonication dispersion nanotubes categorically evaluated paper focuses find effect surfactant mwnt dispersion using visible spectroscopy evaluating effective hydro dynamic diameter based micromechanics based analytical model influence interface layer thickness geometrical configuration nanotubes electrical conductivity cement nano composite also analyzed electrical conductivity mwnt incorporated cement system developed present study measured using four probe method piezo resistivity oven dried samples measured evaluate change potential drop cyclic loading regime found efficiency piezo resistive strain sensors greatly depends synthesis process circuit system appropriately proportioned properly synthesized mwnts incorporated cement matrix capable providing consistent steady response variable external stress thus material used embedded sensor health monitoring identifying initiation damage reinforced concrete structure elsevier ltd rights reserved
objective gauge fertility specialists knowledge clinical practices training needs regard eating disorders design cross sectional study settings fertility clinics participants eighty australian new zealand fertility specialists members fertility society australia intervention none main outcome measures responses anonymously completed online questionnaire result approximately doctors correctly identified body mass index relevant anorexia nervosa identified menstrual disturbances anorexia doctors incorrectly nominated maladaptive weight control behaviors characteristic binge eating disorder clinicians agreed important screen eating disorders preconception assessments routinely screened eating disorders indicated clinics clinical practice guidelines management eating disorders minority participants felt satisfied level university training eating disorders doctors felt confident ability recognize symptoms eating disorder indicated need education clinical guidelines items examined knowledge clinical practices regarding eating disorders differ according doctor gender years clinical experience working fertility specialist conclusion knowledge eating disorders context fertility treatment important study highlights uncertainty among fertility specialists detecting features eating disorders findings point importance education training including development clinical guidelines specific fertility health care providers american society reproductive medicine
background dsm criteria insomnia disorder met adult population insomnia severe consequences health society one common treatments provided primary caregivers pharmacological treatment far optimal recommended since consensus report national institutes health recommended treatment cognitive behavioral therapy insomnia effectiveness however still limited studies evaluated effectiveness chronobiological treatments including timed application bright light physical activity body warming another opportunity optimization treatment based idea people suffering insomnia likely represent heterogeneous mix subtypes different underlying causes expected treatment responses present study aims evaluate possibility optimizing insomnia treatment along principles personalized stratified medicine evaluates following relative effectiveness internet supported cognitive behavioral therapy bright light physical activity body warming whether effectiveness internet supported cognitive behavioral therapy insomnia augmented simultaneous prior application bright light physical activity body warming whether effectiveness interventions combination moderated insomnia subtype methods design repeated measures placebo controlled randomized clinical trial included people diagnosed insomnia disorder evaluating relative effectiveness intervention weeks primary outcome subjective sleep efficiency quantified using sleep diary secondary outcomes include complaints sleep daytime functioning health related cost estimates actigraphic objective sleep estimates compliance monitored subjectively objectively using activity light temperature sensors insomnia subtypes assessed using questionnaires mixed effect models used evaluate intervention effects moderation insomnia subtype ratings discussion current study addresses multiple opportunities optimize personalize treatment insomnia disorder
increase environmental health literacy ehl leadership skills latino youth salinas worked members chamacos youth community council ycc outreach arm longitudinal study impacts environmental chemicals children health ycc program provided hands research experiences related endocrine disrupting chemicals edcs cosmetics possible health effects use participatory research principles bloom taxonomy educational objectives describe development ehc leadership youth researchers using data multiple qualitative sources explore youths engagement wide range research action processes promising outcomes including perceptions improved youth self esteem ehl leadership career orientation discussed challenges time constraints high priority youth concerns addressed study implications youth engaged participatory science leadership programs presented
developments technology especially computer science created need storing data variety areas need created term database data stored useful form database data logically integrated file files according relations among one important issues extract knowledge databases hold data useful complete form process called data mining main objective data mining extract implicit useful knowledge huge first glance meaningless mass data stored database multi relational databases ones data stored multiple tables relations relationships tables also stored tables relations database effective commonly known approaches multi relational data mining mrdm based inductive logic programming ilp ilp contains concepts inductive learning logic programming point main purpose mrdm extracting implicit trivial knowledge relational database using ilp approaches techniques approach data represented graph structures graph mining techniques used knowledge discovery concept discovery multi relational data mining aims find relational rules best describe relation called target relation terms relations database called background knowledge study graph based concept discovery method concept discovery presented proposed method namely cds graph based concept discovery system utilizes methods substructure based path finding based approaches hence considered hybrid method cds generates disconnected graph structures target relation related background knowledge initially stored relational database utilizes guide generation summary graph summary graph traversed find concept descriptors set experiments conducted datasets belong different learning problems experimental results show cds capable learning definitions target relations belong different learning problems
psoriatic arthritis psa chronic inflammatory rheumatic disease broad clinical spectrum psa affect axial skeleton peripheral joints entheses synovial sheaths tendons skin nails extra arti cular organs tumour necrosis factor alpha blockers tnf blockers breakthrough development treatment psa identifying predictors response biological therapies patients psa utmost importance especially view costs potential side effects agents aims present study determine baseline predictive factors response biological therapies months psa patients polyarticular involvement without axial involvement data collected rheumatic diseases portuguese register reuma eligible patients anti tnf naive baseline least months follow beginning tnf blocker therapy patients information least one response measures months follow included analy sis univariable logistic regression analysis potential baseline predictors european league rheumatism eular good clinical response eular good moderate response joint disease activity score three variables including erythrocyte sedimentation rate das esr remission health assessment questionnaire haq response performed multivariable logistic regression using forward selection procedure used best fit model obtained taking confounding effects account total patients eligible study mean age years women multivaria ble analysis months females less likely attain good eular response das esr remission moderate good eular response haq response months female gender also less likely achieve good eular response das esr remission haq response study found gender consistent predictor response tnf blocker therapy patients polyarticular psa females lower probability response compared males findings suggest gender related biochemical hormonal psychological factors could play important role response tnf blocker therapy psa
work discusses design construction operation low cost farm scale digester animal wastes used biogas produced contains volume production quantities qualities measured period six months summer winter biogas used two different systems instant gas water heater used generate hot water farm use modified piston engine driving electrical generator one phase one output fueled directly gas operation systems satisfactory unit used demonstrate technology potential users farm owners
background family caregivers people dementia significant unmet needs regard caregiving role despite reluctant utilize services reduce burden aim study examine barriers facilitators service use among family caregivers people dementia method semi structured interviews conducted family caregivers community dwelling people dementia partner caregivers men women offspring caregivers men women interviews transcribed analyzed using thematic analysis results six main barriers three facilitators identified barriers facilitators relevant across many types services supports barriers inability find information relevant services support poor quality mistrust services inflexibility services caregivers beliefs obligations caregiving role resistance care recipient key facilitators good communication care recipient expert point contact beliefs caregiving role enabled use services conclusion given significant changes aged care service system important discuss barriers faced family caregivers people dementia inform development targeted strategies address lack service use among family caregivers
ulcerative colitis chronic intestinal inflammatory disease receptor interacting protein kinase rip reported involved many inflammatory disease however mechanism rip pathogenesis still unclear investigate effects possible mechanism rip pathogenesis rip mice used dextran sulfate sodium dss induced colitis model found dss induced colitis rip mice showed significantly enhanced colitis symptoms including increased weight loss colon shortening colonic mucosa damage severity decreased production interleukin interleukin results showed rip deficiency could ameliorate exacerbate severity colitis mechanism found messenger rna expressions several repair associated cytokines including interleukin interleukin cyclooxygenase epithelial growth factor receptor ligand epiregulin matrix metalloproteinase siginificant decreased rip mice thus rip mice exhibited impaired tissue repair response dss conclusion rip deficiency exerted detrimental effects dss induced colitis partially impaired repair associated cytokines expression
background objective contraceptive pills generally taken orally cause side effects nausea vomiting hypertension vaginal use pills reduce complications objective compare efficacy side effects low dose contraceptive pills oral vaginal route management dysfunctional uterine bleeding dub methods comparative observational study conducted beheshti alzahra teaching hospitals affiliated isfahan university medical sciences one hundred women presented dub randomly assigned two groups equal number receiving low dose oral contraceptive pills oral vaginal route three month amount duration bleeding compared beginning end study side effects two methods compared results results study showed oral vaginal routes effectively reduced duration amount bleeding due dub three courses treatment effect better vaginal method compared oral administration regarding side effects nausea vomiting significantly higher oral group vaginal group vulvovaginitis infection frequent vaginal group oral group conclusion low dose contraceptive pills effective reducing amount time duration bleeding patients dub addition reduction gastrointestinal side effects vaginal route helps use pills patient proper training physicians midwives patients
increasing awareness role played circadian rhythm abnormalities neurodegenerative disorders alzheimer disease parkinson disease characterization circadian dysfunction parallels mounting evidence hallmarks neurodegeneration also affect retina frequently lead loss retinal ganglion cells rgcs different degrees optic neuropathy rgc population subgroup cells intrinsically photosensitive expressing photopigment melanopsin melanopsin containing retinal ganglion cells mrgcs well known drive entrainment circadian rhythms light dark cycles thus correlation pathological changes affecting retina mrgcs circadian imbalance neurodegenerative diseases clearly emerging pointing possibility patients might amenable benefit light therapy currently connection better established scenario may apply neurodegenerative disorders huntington disease review highlights similarities differences retinal circadian rhythm axis neurodegenerative diseases posing working frame future studies
relationship psychopathy antisocial personality disorder apd explored sample australian mentally disordered offenders two hare adult psychopathy measures psychopathy checklist revised pcl psychopathy checklist screening version pcl employed diagnosis apd measured participants secure forensic psychiatric inpatient facility results revealed clear distinctions measurements psychopathy apd patients high psychopathic traits received diagnosis apd patients apd high psychopathic traits denoting asymmetric relationship implications assessment treatment mentally disordered offenders psychopathic traits discussed
immunomodulatory anti inflammatory properties bone marrow derived mesenchymal stem cells mscs considered appropriate candidate treatment autoimmune diseases previous studies revealed treatment mscs may modulate immune responses alleviate symptoms experimental autoimmune encephalomyelitis eae mice animal model multiple sclerosis therefore present study designed examine immunomodulatory effects mscs treatment myelin oligodendrocyte glycoprotein mog induced eae cbl mice mscs obtained bone marrow cbl mice cultured dmem characterized flow cytometry presence cell surface markers mscs following three passages mscs injected intraperitoneally eae mice alone combination rapamycin immunological histopathological effects mscs addition rapamycin mscs evaluated results demonstrated adding rapamycin mscs transplantation eae mice significantly reduced inflammation infiltration demyelination enhanced immunomodulatory functions inhibited progress neurological impairments compared msc transplantation control groups immunological effects rapamycin msc treatments associated inhibition specific lymphocyte proliferation cytolytic activity type cytokine gamma interferon ifn gamma increase cytokine interleukin production addition rapamycin mscs able ameliorate neurological deficits provide neuroprotective effects eae suggests potential rapamycin msc combined therapy play neuroprotective roles treatment neuroinflammatory disorders
lot emphasis theoretical education rather practical ability training programming courses colleges universities giving rise low programming ability students severe impact professional development automatic judgement based online judge system suitable exploration learning collaborative learning paper uses principle blended learning proposes set blended learning modes combine online judge computer programming courses paper first describes design ideas blended learning mode learning environment resource learning content form learning evaluation author takes programming language course example elaborate practical measures blended learning finally comparative experiments show application mode improved significantly knowledge points amount code test scores students traditional methods application blended learning model based online judge system programming courses plays positive role students programming logical thinking research innovation capabilities
new state space approach proposed model time dependence extreme value process generalized extreme value distribution extended incorporate time dependence using state space representation state variables either follow autoregressive process moving average process innovations arising gumbel distribution using bayesian approach efficient algorithm proposed implement markov chain monte carlo method exploit accurate approximation gumbel distribution ten component mixture normal distributions methodology illustrated using extreme returns daily stock data model fitted monthly series minimum returns empirical results support strong evidence time dependence among observed minimum returns elsevier rights reserved
idiopathic pulmonary fibrosis ipf lethal lung disease year mortality rate unknown etiology treatment options remain limited currently two drugs available nintedanib pirfenidone however antifibrotic agents slow progression disease remarkably prolong survival ipf patients hence discovery new therapeutic targets ipf crucial studies exploring mechanisms involved ipf identified several possible targets therapeutic interventions among blood coagulation factor receptors protease activated receptors pars key candidates receptors mediate cellular effects coagulation factors play central roles influencing inflammatory fibrotic responses review focus controversial role coagulation cascade pathogenesis ipf light novel data attempt reconciliate apparently conflicting data discuss possibility pharmacologic targeting pars treatment fibroproliferative diseases
new procedure extract parameters mathematical models describe charge flow phenomena thin dielectrics proposed characterizing undesirable leakage current mechanisms modern mosfets gates procedure basis small signal conductance current ratio characteristics alternative advantages presently used methods extract models parameters slope intercept phenomenon specific linear plots contrast generic method may directly applied characteristics regardless specific leakage mechanism involved procedure inherently reduces one number unknowns needs determined numerical optimization addition require traditional methods prior knowledge exact relationship applied voltage effective internal electric field strength case determined together parameters procedure illustrated three examples different kinds data mathematically synthesized computer aided design simulated experimentally measured leakage characteristics mos capacitors
energy sector worldwide everyday comes new challenges whether find renewable energy source energy source degrade environment efficiency satisfy implementation work energy reuse system cogeneration trigeneration covered tests performed primary source internal combustion engine kva driven natural gas generates electric power synchronous generator coupled motor shaft energy loss exhaust gas recovered absorption refrigeration system first system restructured reuse gases rejected generator absorption refrigeration system order preheat fluid oil used biodiesel plant driven source unit high performance generation classified cogeneration trigeneration depending type arrangement tested meet physical facilities laboratory control instrumentation energy environment mechanical workshop institute sustainable energy ufpb also building recogas study constituent energy power term polygeneration system considering generator engine group main driven source results shown sankey diagram evaluated allowed check whole process beginning burning fuel end electricity production
backgroundresearch led improvements effectiveness interventions substance use disorders sud part progress modest particularly regard longer term outcomes moreover individuals sud seek treatment argument analysisthis paper presents two recommendations improve treatment engagement long term outcomes sud first treatments beyond focus reducing eliminating substance use target greater access time spent experiences enjoyable otherwise rewarding clients secondly must sufficient incentives environment justify effort needed sustain long term abstinence individuals often limited access incentives conclusionsto increase rates long term recovery substance misuse treatments link clients reinforcers make continued abstinence appealing work needs extend beyond interventions focused individual family include local community national policy effort incentivize longer term recoveries strongly
article seeks present necessary context preliminary approach understanding addressing birth control debate colombia covers main conflicting positions period discourses logics permeating arrival north american family planning programs latin america form political control revolutionary movements
major cause fatal construction accidents falls height ffh study human factor analysis classification system hfacs adopted modified assist classifying root causes fatal ffh accidents hong kong characteristics root causes accidents analyzed using frequency analysis associations among causes examined using fisher exact test latent class analysis lca cases apparently share common characteristics certain hfacs factors closely associated according lca results factors cases may placed four classes named ill planning violation hidden hazards created others incapable staffing recommendations made reduce ffh construction accidents based characteristics root causes paper contributes body knowledge construction management developing modified hfacs framework extracting structured information construction accident reports finding general characteristics managerial causes behind ffh accidents using lca identify connections among managerial causes
dielectric actuators utilized convert electrical power mechanical strain considerable potential microrobotic applications however critical challenges need addressed include high voltage interface high conversion ratio light weight small size high power density study proposes high piezoelectric transformer based high conversion ratio interface integrated direct current direct current high conversion ratio boost stage direct current alternating current high voltage driving stage piezoelectric transformer based class zero voltage switching direct current direct current interface controlled hybrid pulse frequency modulation pulse width modulation control strategies obtain desired high step ratio direct current direct current stage half bridge converter special digital control algorithm direct current alternating current stage designed convert high direct current voltage arbitrary unipolar signal driving dielectric actuators prototype interface fabricated experimental validation verify ability drive input dielectric actuator microrobotic applications
carbon based nanomaterials serve type smart material photo triggered disease theranostics inherent physicochemical properties nanomaterials facilitate use less invasive treatments review summarizes properties applications materials including fullerene nanotubes nanohorns nanodots nanographenes photodynamic nanomedicine cancer antimicrobial therapies carbon nanomaterials usually act photodynamic therapy pdt agents owing high hydrophobicity however surface passivated functionalized materials become great vehicles pdt moreover conjugation carbonaceous nanomaterials photosensitizer relevant targeting ligands enhances properties selectivity stability high quantum yield making readily available versatile biomedical applications
acitretin one systemic agents used treatment psoriasis different acitretin dosages resulted therapeutically successful general agreement optimal dose regimen report acitretin efficacy safety real life setting wherein patient tailored dose regimen usually prescribed retrospective analysis evaluating charts plaque type psoriasis patients treated acitretin clinic database performed pasi score improvement well pasi responses assessed throughout observational period overall pasi score reduction satisfactory safety profile detected pasi response achieved respectively treatment consisted mean daily acitretin dose initial dose increased cases decreased prescribing mean daily dose respectively study proposed dose regimen customized clinical response patient needs optimized acitretin benefit
trend toward fiercely competitive strictly environmentally regulated electricity market several countries including china led efforts industry government develop advanced performance evaluation models adapt new evaluation requirements traditional operational environmental efficiency measures fully consider influence market competition environmental regulations thus sufficient thermal power industry evaluate operational performance respect specific marketing goals operational effectiveness environmental performance respect specific emissions reduction targets environmental effectiveness complement operational efficiency measure operational effectiveness measure reflects capacity electricity production system increase electricity generation improvement operational efficiency also reflects system capability adjust electricity generation activities match electricity demand addition complement environmental efficiency measure environmental effectiveness measure reflects capacity electricity production system decrease pollutant emissions improvement environmental efficiency also reflects system capability adjust emissions abatement activities fulfill environmental regulations furthermore environmental effectiveness measure helps government regulator verify rationality emissions reduction targets assigned thermal power industry several newly developed effectiveness measurements based data envelopment analysis dea utilized study evaluate operational environmental performance thermal power industry china efficiency effectiveness evaluated three perspectives operational environmental joint adjustments electricity production system operational environmental performance changes time also captured effectiveness measure based global malmquist productivity index empirical results indicated performance china thermal power industry experienced significant progress study period policies regarding development regulation thermal power industry yielded expected effects however emissions reduction targets assigned china thermal power industry loose conservative elsevier ltd rights reserved
nowadays distributed denial service ddos becomes major challenge network affects network multi level leads traffic overhead wastage bandwidth utilisation order overcome issues ant based ddos detection technique using roaming virtual honeypots proposed technique virtual roaming honeypot along multi level secure architecture used collect information various intruders different levels network ant colony optimisation technique used detect intruders based pheromone deposit considered area multi level log table used detect intruders different levels network affected area found information sent multi level architecture limit spread affected area honeypot information sent honeypot make defence system attackers advantage proposed technique provides full defence ddos multi level without creating traffic overhead
background metabolic syndrome mets collection clinical conditions including central obesity hypertension glucose intolerance dyslipidemia long term inflammatory metabolic dysfunction associated mets may contribute osteoarthritic processes leading total joint arthroplasty tja purpose study investigate levels metabolic biomarkers prevalence mets patients undergoing tja methods irb approval citrated plasma samples collected patients undergoing total hip knee arthroplasty tha tka preoperatively day postoperatively control group consisted healthy human plasma samples female male years old purchased george king biomedical inc overland park usa samples profiled peptide ferritin insulin resistin tnf alpha leptin pai using metabolic biochips purchased randox antrim northern ireland ncep atp iii guidelines used evaluate patients met mets criteria results levels resistin tnf leptin pai significantly elevated patients uridergoing tja compared normal peptide insulin decreased tja compared normal significance found comparing tja normal ferritin tnf alpha significantly lower tja mets compared tja mets biomarkers showed diffbrence tja mets populations insulin peptide showed significant decrease tja mets compared normal levels tja mets patients significantly different controls resistin showed significant increases tja mets normal tja mets normal conclusions overall differing metabolic profile seen patients undergoing tja suggest ongoing metabolic dysfunction insulin peptide patterns among different test groups hint toward complex dysfunctional metabolic process involved leptin underlying insulin resistance playing role increased resistin tja mets tja mets compared normal suggests elevated resistin levels may associated osteoarthritic process levels attenuated mets highly prevalent population increased tnfa tja mets compared tja mets may artifact differing sample populations true complication complex pathophysiology medical regimen seen patients mets lack difference seen remaining biomarkers suggest mets comorbidity contribute elevated levels seen patients undergoing tja
research pain judgement shown several features target influence empathy others pain considering pivotal role morality social judgement investigated whether judgements others social physical suffering vary function target moral status study manipulated moral characteristics unknown found participants ascribed less social physical suffering target depicted lacking moral status rather target high morality study added control condition information target moral qualities provided showed effect morality social pain judgements driven depiction target lacking moral traits study revealed specific role morality information another evaluative dimension competence effects pain judgements study showed social targets perceived lacking moral qualities thought experience less social pain highly moral targets perceived lower level humanity overall findings suggest social physical pain might represent capacity denied social targets perceived low morality
function metformin colorectal cancer crc patients diabetes mellitus remains controversial topic studies increasingly focusing epidemiologic features examined notch hes signaling crc crc investigated alterations signaling caused metformin treatment purpose information pathological characteristics collected patient proliferation epithelium labeled proliferating cell nuclear antigen differentiation goblet cells investigated using immunohistochemistry periodic acid schiff staining respectively factors involved notch hes signaling detected using qrt pcr western blot study found lymphatic metastasis ptnm staging carcinoembryonic antigen level significantly different groups depth crypts rate proliferating cell nuclear antigen positive cells distinctly higher crc patients managed insulin moreover goblet cell differentiation rate decreased crc expression dll notch math rbp increased crc whereas expression dll hes decreased group normal tissue crc tissue expression dll notch clearly higher crc furthermore trend changes aggravated insulin management alleviated metformin treatment conclusion abnormal cell proliferation differentiation observed crc correlated overactivated notch hes signaling potentially relieved metformin treatment
background affordable feasible efficacious interventions reduce neonatal infections improve neonatal survival needed chlorhexidine broad spectrum topical antiseptic agent active aerobic anaerobic organisms reduces neonatal bacterial colonisation may reduce infection objectives evaluate efficacy neonatal skin cord care chlorhexidine versus routine care treatment prevention infections late preterm term newborn infants hospital community settings search methods searched central latest issue cochrane library medline november embase november cinahl november ongoing trials detected searching following databases www clinicaltrials gov www controlled trials com selection criteria cluster individual patient randomised controlled trials chlorhexidine use skin care cord care term late preterm neonates hospital community settings eligible inclusion three authors independently screened selected studies inclusion data collection analysis two review authors independently extracted data assessed study risk bias quality evidence outcome assessed using grade calculated pooled risk ratios rrs risk differences rds confidence intervals cis presented results using grade summary findings tables main results included trials review seven hospital based five community based studies four studies maternal vaginal wash chlorhexidine done addition neonatal skin cord care newborn skin cord cleansing chlorhexidine compared usual care hospitals low quality evidence one trial showed chlorhexidine cord cleansing compared dry cord care may lead difference neonatal mortality moderate quality evidence two trials showed chlorhexidine cord cleansing compared dry cord care probably reduces risk omphalitis infections low quality evidence two trials showed chlorhexidine skin cleansing compared dry cord care may lead difference omphalitis infections none studies comparison reported effects treatments neonatal mortality newborn skin cord cleansing chlorhexidine compared usual care community high quality evidence three trials showed chlorhexidine cord cleansing compared dry cord care reduces neonatal mortality omphalitis infections high quality evidence one trial showed difference chlorhexidine skin cleansing usual skin care neonatal mortality none studies comparison reported effects treatments omphalitis infections maternal vaginal chlorhexidine addition total body cleansing compared intervention sterile saline solution hospitals moderate quality evidence one trial showed difference maternal vaginal chlorhexidine addition total body cleansing intervention neonatal mortality high quality evidence two trials showed difference maternal vaginal chlorhexidine addition total body cleansing intervention risk infections findings one trial showed maternal vaginal cleansing addition total body cleansing results increased risk hypothermia maternal vaginal chlorhexidine addition total body cleansing compared intervention sterile saline solution community low quality evidence one trial showed difference maternal vaginal chlorhexidine addition total body cleansing intervention neonatal mortality moderate quality evidence one trial showed maternal vaginal chlorhexidine addition total body cleansing compared intervention probably reduces risk neonatal infections studies report effect omphalitis authors conclusions uncertainty effect chlorhexidine applied umbilical cords newborns hospital settings neonatal mortality quality evidence effects infection moderate cord application low application skin high quality evidence chlorhexidine skin cord care community setting results reduction incidence omphalitis reduction neonatal mortality maternal vaginal chlorhexidine compared usual care probably leads difference neonatal mortality hospital settings maternal vaginal chlorhexidine compared usual care results difference risk infections hospital settings uncertainty effect maternal vaginal chlorhexidine mortality outcomes reflects small sample sizes low event rates community settings
background data available comparing cardiovascular disease cvd biomarker profiles women men general population analyzed sex based differences multiple biomarkers reflecting distinct pathophysiological pathways accounting differences women men cvd risk factors body composition cardiac morphology methods cross sectional analysis performed using data dallas heart study multiethnic population based study associations sex distinct biomarkers representative pathophysiological categories evaluated using multivariable linear regression adjusting age race traditional cvd risk factors kidney function insulin resistance mri dual energy ray absorptiometry measures body composition fat distribution left ventricular mass results excluding participants cvd study population included individuals mean age years women black significant sex based differences seen multiple categories biomarkers including lipids adipokines biomarkers inflammation endothelial dysfunction myocyte injury stress kidney function fully adjusted models women higher levels high density lipoprotein cholesterol high density lipoprotein particle concentration leptin dimer homoarginine terminal pro type natriuretic peptide lower levels low density lipoprotein cholesterol adiponectin lipoprotein associated phospholipase mass activity monocyte chemoattractant protein soluble endothelial cell adhesion molecule symmetrical dimethylarginine asymmetrical dimethylarginine high sensitivity troponin cystatin conclusions biomarker profiles differ significantly women men general population sex differences apparent biomarkers adiposity endothelial dysfunction inflammatory cell recruitment cardiac stress injury future studies needed characterize whether pathophysiological processes delineated biomarkers contribute sex based differences development complications cvd
purpose vitro study evaluated effects four different cements color attributes zirconia ceramic materials methods zirconia ceramic disk specimens thickness diameter cement space fabricated computer aided design computer aided manufacturing system specimens divided groups specimens cemented composite substrates using four different cements including glass lonomer panavia zinc phosphate tempbond color attributes specimens measured cementation spectrophotometer additionally delta values measured determine color changes groups compared perceptional threshold delta repeated measures anova tukey post hoc bonferroni one way anova one sample test tests used analyze data tests carried level significance results statistically significant differences detected values zinc phosphate tempbond groups however statistically significant differences respect glass lonomer panavia groups means standard deviations delta values glass lonomer panavia zinc phosphate tempbond groups unit respectively conclusion within limitations study concluded zinc phosphate tempbond cements affected color attributes tested zirconia ceramic beyond perceptional threshold however glass lonomer panavia cements created acceptable color changes
work addresses multi scale modeling fluid flow highly complex media based concept representative volume element rve method multi scale virtual power developed authors employed construct coarse scale model standard fluid flow model fine scale kinematic conservation principles duality arguments balance virtual power scales employed set grounds scale transition physical fields allows derive variationally consistent manner fine scale problem solved rve homogenization formulae coarse scale dual quantities namely force like stress like fields examples application flow permeable media presented show potential present approach elsevier rights reserved
objective objective study identification stain hif alpha using image cytometry help count positive cells hif alpha negative cells without hif alpha sample method images renal tissues male rats winstar lineage overall objects cells images analysis acquired images analyzed free softwares cellprofiler version cellprofiler analyst version software cellprofiler anlyst separation classes object using classifier classes class hif alpha class without hif alpha results data obtained score possible calculate percentage cells hifalpha objects sample hif alpha hif alpha data sensibility specificity standard deviation conclusion research shows free software cellprofiler light microscope able identify stains perform machine learning subsequently count separate cells distinct classes without stain hif alpha elsevier rights reserved
modified form sequential function specification method sfsm developed specific consideration given multiple time scales effort avoid overregularization solution estimates authors extend approach solve inverse heat conduction problem ihcp associated application thermal barrier coatings tbc cylinder surfaces internal combustion engine subsurface temperature measurements used calculate surface heat flux profiles modified inverse solver validated situ using custom fabricated radiation chamber solution methodology extended situ evaluate temperature data collected single cylinder research engine operating homogeneous charge compression ignition hcci mode crank angle resolved thermal barrier coating surface temperature heat flux profiles produced enabling correlation thermal conditions gas wall boundary engine performance emission efficiency metrics
study investigated structural behavior long span partially earth anchored cable stayed bridges main span length use new key segment closing method based thermal prestressing technique detailed construction sequence analysis matched free cantilever method fcm performed using three dimensional finite element model partially earth anchored cable stayed bridge new method offers effective way connecting key segments avoiding large movements resulting removal longitudinal restraint owing asymmetry axial forces girders near pylons new method develops new member forces process heating cantilever system installing key segment cooling system continuously installing key segments resulting forces developed thermal process enhance structural behavior partially earth anchored cable stayed bridges owing decreased axial forces girders
introduction medial orbitofrontal cortex involved regulation feeding metabolism little known however role local glucose monitoring neurons processes knowledge also poor characteristics cells aim functional significance chemosensory neurons elucidated method electrophysiology multibarreled microelectrophoretic technique metabolic investigations streptozotocin induced selective destruction chemosensory neurons employed results fifteen percent neurons responded glucose chemosensory cells displayed differential neurotransmitter taste sensitivities acute glucose tolerance test minutes blood glucose level streptozotocin treated rats significantly higher controls plasma triglyceride concentrations also higher streptozotocin treated group conclusions glucose monitoring neurons medial orbitofrontal cortex integrate internal external environmental signals monitor metabolic processes thus indispensable maintain healthy homeostasis
existing writings explore relationship inter korean relations political economy south korea stress role ruling ideology anti communism domestic struggle power hegemony also consider kim dae jung member hegemonic group represented interests bourgeoisie thus contend level inter korean reconciliation presidency product hegemonic group accommodation people nationalist demands arguments however contradictory among things kim one severely damaged hegemonic group ruling ideology drawing gramsci concepts historical bloc hegemonic project attempt resolve contradiction arguing kim member hegemonic group leader counter hegemonic liberal nationalists accordingly article demonstrates kim stance chaebol centred economic structure abortive attempt change token argues inter korean reconciliation hegemonic project realise liberal nationalists vision peaceful unification liberal approach undermine anti communism hegemonic group exercised ideological leadership decades
social cognitive deficits common neuropsychiatric disorders given proximity social cognition everyday functioning many intervention studies including targeted comprehensive broad based approaches focussed aim paper quantitatively meta analyse efficacy interventions adult neuropsychiatric patients databases pubmed psycinfo web knowledge embase searched controlled intervention studies published forty one studies comprising patients schizophrenia autism spectrum disorders acquired brain injury included outcome measures evaluated emotion perception social perception theory mind tom social functioning meta analyses showed interventions effective improving cohen interventions targeting one specific function found effective followed broad based interventions targeting non domains addition comprehensive interventions target multiple processes targeted interventions especially effective improving tom comprehensive interventions able ameliorate tom broad based interventions especially effective improving also showed effects tom
introduction attention deficit hyperactivity disorder adhd anxiety frequently comorbid disorders associated different types abnormal performance neuropsychological tests although studies shown comorbid anxiety alters adhd test performance results inconsistently show improvements worsening different abilities failures replicate across different anxiety disorders alternatively trait anxiety may reflect stable influence adhd test performance various diagnosable anxiety disorders method better understand possible enhancing deleterious effects anxiety adhd cognitive impairments study examined effect individual differences trait anxiety measured multidimensional anxiety scale children masc battery computerized rapid performance tests measuring attention impulsivity related performance diagnostic statistical manual mental disorders fourth edition dsm combined subtype adhd adolescents healthy controls hypothesized trait anxiety would attenuate response inhibition attention deficits adhd results adhd diagnosed adolescents higher trait anxiety performed better indices sustained attention reaction time motor variability altered overall test performance strategy response inhibition affected adhd non adhd conclusions study provides first evidence pathological levels anxiety needed see differences adhd neuropsychological test performance instead mildly elevated trait anxiety confers protective influence reducing degree impairment seen adhd findings suggest better performing adhd adolescents might optimized levels cortical arousal raise new questions best identify neurobiological substrates responsible beneficial effects
paper propose new floor field cellular automaton model considering swapping behaviors pedestrians neighboring pedestrians opposite directions take swapping probability decided linear density pedestrian flow swapping happens simultaneously normal movement introduced eliminate gridlock low density region numerical results show fundamental diagram good agreement measured data model applied investigate counterflow four typical states free flow lane intermediate congestion states found attention paid intermediate state lane formation local congestions switch irregular manner swapping plays vital role reducing gridlock furthermore influence corridor size individual eyesight counterflow discussed detail elsevier rights reserved
estimate prevalence lifetime use crack cocaine assess associations violent sexual behaviors young adults selected general population pelotas southern brazil cross sectional population based study included participants aged years use alcohol substances including crack cocaine assessed using alcohol smoking substance involvement screening test variables included violent behaviors firearm possession sexual risk behaviors frequency antisocial personality disorder also investigated associations analyzed using crude model models adjusted sex social class use snorted cocaine lifetime prevalence crack cocaine use higher among males individuals coming vulnerable social classes final multivariate models lifetime use crack cocaine associated episodes aggression firearm possession well higher chance used condom last sexual intercourse less conservative models crack cocaine use associated violent sexual risk behaviors strong association observed lifetime use crack cocaine different violent sexual risk behaviors underscores relevant characteristics people use crack cocaine improving understanding possible causal chains leading associations priority future studies
photo electro chemical production hydrogen water splitting efficient sustainable method utilization solar energy improve photo electro catalytic activity schottky type barrier typically useful separate excited charge carriers semiconductor electrodes focused studying band diagrams schottky type barrier heights tan one promising materials photoanode water splitting band alignments undoped type tan adsorbents vacuum examined determine impurities adsorbents affect band positions fermi energies band edge positions well density surface states clearly depended density impurities bulk surface regions finally band diagrams type tan water interfaces calculated improved interfacial model include effect electrode potential explicit water molecules observed partial fermi level pinning calculations tan water interface affects driving force charge separation
autoimmune inflammatory syndrome induced adjuvants asia entity includes different autoimmune conditions observed exposure adjuvant patients undifferentiated connective tissue disease uctd present many signs symptoms asia alluding idea exposure adjuvants trigger also uctd aim case control study investigate exposure adjuvants prior disease onset patients affected uctd ninety two uctd patients age sex matched controls malignancy chronic infections autoimmune disease family history autoimmune diseases investigated exposure adjuvants hoc created questionnaire exploring exposure vaccinations foreign materials environmental occupational exposures administered cases controls autoantibodies also analyzed anti nuclear anti extractable nuclear antigens anti double stranded dna anti cardiolipin anti beta glycoprotein uctd patients displayed greater exposure hbv tetanus toxoid vaccinations metal implants cigarette smoking pollution due metallurgic factories foundries compared controls uctd patients exposed major asia triggers vaccinations silicone implants presented frequently chronic fatigue general weakness irritable bowel syndrome family history autoimmunity comparison non exposed uctds asia uctd considered related entities mosaic autoimmunity genetic predisposition environmental exposure adjuvants elicit common clinical phenotype characterized signs symptoms systemic autoimmunity
paper presents novel fixation prediction saliency modeling framework based inter image similarities ensemble extreme learning machines elm proposed framework inspired two observations contextual information scene along low level visual cues modulates attention influence scene memorability eye movement patterns caused resemblance scene former visual experience motivated observations develop framework estimates saliency given image using ensemble extreme learners trained image similar input image retrieving set similar images given image saliency predictor learnt images retrieved image set using elm resulting ensemble saliency given image measured terms mean predicted saliency value ensemble members elsevier rights reserved
introduction psoriasis pso chronic inflammatory skin disease associated morbidities hypertension diabetes dyslipidemia metabolic syndrome typothypical disease affects world population numerous drugs used clinical practice choice drugs depends characteristics patient areas covered apremilast first oral small molecules receive fda approval treatment adults active psoriasis psoriatic arthritis small molecule specifically inhibits activity cyclic amp phosphodiesterase pde several analyses performed data phase iii studies assess apremilast safety efficacy psoriasis psoriatic arthritis psa apremilast could also represent treatment opportunity patients unresponsive systemic biological agents whose treatment contraindicated expert opinion safety profile easy route administration apremilast may offer oral treatment option patients discontinue treatments ineffectiveness intolerability ineligibility currently available drugs
paper presents research work related development wireless sensor networks wsn gathering environmental data surface moon data aggregation algorithms applied reduce amount multi sensor data collected wsn sent moon orbiter later earth particular issue utmost importance space applications energy efficiency main goal research optimise algorithm design wsn energy consumption reduced extensive simulation experiment carried confirms use proposed algorithms enhances significantly network performance terms energy consumption compared routing raw data addition proposed data aggregation algorithms implemented successfully system chip soc embedded platform using xilinx zynq fpga device data aggregation two important effects wsn life time extended due saved energy original data accuracy preserved research could beneficial number future security related applications monitoring phenomena may affect earth planetary security safety well monitoring implementation moon treaties preventing establishment military bases lunar surface
roadmap semi algebraic set curve non empty connected intersection connected components hence kind object introduced canny used answer connectivity queries applications instance motion planning also become central importance effective real algebraic geometry since used higher level algorithms article provide probabilistic algorithm computes roadmaps smooth bounded real algebraic sets output size running time polynomial nlog maximum degrees input polynomials dimension set consideration number variables precisely running time algorithm essentially subquadratic output size even assumptions first roadmap algorithm output size running time polynomial nlog
studying vibration bridge vehicle coupled system researchers mainly focus vertical vibration bridges moving vehicular loads lateral longitudinal vibrations bridges stochastic characteristics traffic flows neglected however long span suspension bridges neglecting bridge three dimensional vibrations stochastic traffic flows cause considerable inaccuracy predicting dynamic performance study mainly focused establishing new methodology fully considering suspension bridge vertical lateral longitudinal vibrations induced stochastic traffic flows varied road roughness conditions new full scale vehicle model degrees freedom dofs developed predict longitudinal lateral vibrations vehicle improved cellular automaton model considering influence next nearest vehicle introduced bridge vehicles traffic flow coupled equations established combining equations motion bridge vehicles using displacement relationship interaction force relationship patch contacts numerical simulations show proposed method rationally simulate vibrations suspension bridge stochastic traffic flows
design test multi processor system chips mpsocs development distributed applications operating systems executed hardware platforms one biggest challenges today system design applies particular short time market constraints impose serious limitations exploration design space use virtual platforms help decreasing development test cycles paper present cloud based environment supporting user designing heterogeneous mpsocs developing distributed applications therefore design environment generates virtual platforms automatically allowing fast prototyping cycles especially software development process exports design hardware flow synthesizing compatible fpga designs extension peripheral models debug information supports developer test debug cycles avoids need adding special debug codes application improves readability portability maintainability produced software additionally paper presents benefits using cloud based design environments engineers trainings educations therefore framework supports testing system including complex software stacks prerecorded data testbenches
increasing habitat connectivity important mitigating effects climate change landscape fragmentation habitat loss biodiversity conservation however modelling connectivity relevant scales threats occur limited computational requirements introduce open source software gflow massively parallelizes computation circuit theory based connectivity software developed high performance computing scales consumer grade desktop computers running modern linux mac operating systems report high computational efficiency representing speedup existing software using high performance computing speedup using desktop computer drastically reducing memory requirements gflow allows large extent high resolution connectivity problems calculated many iterations multiple scales envision gflow immediately useful large landscape efforts including climate driven animal range shifts multitaxa connectivity many developing use cases circuit theory based connectivity
differential evolution research multi objective optimization divided proposals either consider stand alone algorithm see algorithmic component coupled algorithm components general evolutionary multiobjective optimization emo literature contributions latter type shown components greatly improve performance existing algorithms nsga spea ibea however several experimental factors left aside type algorithm design compromising generality work revisit research effectiveness multi objective optimization improving several ways particular conduct iterative analysis algorithmic design space considering environmental selection components factors results show great level interaction algorithm components indicating effectiveness depends combined designs present state art performance confirming effectiveness multi objective optimization
recent evidence suggests type diabetes associated accelerated brain ageing consistent observation increased risk cognitive impairment dementia affected individuals even non diabetic individuals impaired fasting plasma glucose ifg levels shown increased cerebral atrophy compared individuals normal glucose levels tested whether longitudinal rates age related cortical thinning associated fasting plasma glucose levels large sample early old age individuals years scanned magnetic resonance imaging four occasions years higher plasma glucose levels measured three occasions associated increased cortical thinning individuals well ifg similar trend individuals normal fasting glucose nfg levels across groups mmol increase plasma glucose mmol nfg ifg mmol resulted increase annual cortical thinning increased cortical thinning detected insular cortex well posterior cingulate parahippocampus medial orbitofrontal cortex results provide support idea raised plasma glucose levels even normal range associated accelerated age related cortical atrophy
sororities identified placing young women risk body image concerns due focus traditional gender role norms objectification women objective study assessed relationship conformity feminine gender role norms self objectification body image surveillance among undergraduate women participants random sample undergraduates authors examined data sorority nonsorority women methods random sample undergraduate women authors assessed impact traditional feminine gender role norms self objectification body image feedback regarding physical appearance sorority nonsorority undergraduate women results three linear regressions conducted conformity feminine gender role norms contributed significantly regression model conclusions regardless sorority membership conformity feminine gender role norms found significantly contribute increased body consciousness negative body image feedback physical appearance
objective investigate cardiometabolic effects severe hypothyroid state induced withdrawal thyroid hormone replacement radioactive iodine therapy methods patients thyroid cancer scheduled receive radioactive iodine ablation enrolled cardiometabolic parameters measured using blood samples taken immediately levothyroxine withdrawal weeks following withdrawal radiotherapy day weeks following reinstitution levothyroxine results patients age years female severe hypothyroid state induced levothyroxine withdrawal significantly aggravated majority lipid parameters particularly patients greater number metabolic syndrome components fasting plasma glucose levels homeostatic model assessment values insulin resistance beta cell function significantly decreased following levothyroxine withdrawal serum high sensitivity reactive protein fibrinogen cystatin levels significantly decreased homocysteine levels increased severe hypothyroid state changes reversed levothyroxine reinstitution conclusions severe hypothyroid state induced pronounced changes cardiometabolic parameters studies identify long term effects changes parameters cardiovascular morbidity mortality relation thyroid disease
simple accurate scheme modeling microstructures proposed help element trimming combined signed distance function based boundary smoothing accommodate randomly distributed fibers unidirectional composites digital image processing used interfaces multi materials identified introducing signed distance function square background elements crossing interfaces simply trimmed divided represent single material behavior single element element trimming elements polygon shaped two dimensional domain split conventional three node triangle elements six node prism elements three dimensional domain available many commercial software packages present modeling scheme verified benchmark examples terms accuracy efficiency applied modeling unidirectional composites based real microscopic images evaluate equivalent elastic properties elsevier ltd rights reserved
theoretical model proposed specifies lay causal theories behavior supporting experimental evidence presented model basic assumption different types behavior trigger different hypotheses concerning types causes may brought behavior seven categories distinguished assumed serve behavior types explanation types goals dispositions temporary states emotions intentional actions outcomes events stimulus attributes model specifies inference rules lay people use explaining behavior actions caused goals goals caused higher order goals temporary states temporary states caused dispositions stimulus attributes events outcomes caused actions temporary states dispositions stimulus attributes events events caused dispositions preceding events two experiments reported experiment showed free response explanations followed assumed inference rules experiment demonstrated explanations match inference rules generated faster frequently non matching explanations together findings support models incorporate knowledge based aspects process causal explanation results discussed respect implications different stages process activation causal hypotheses subsequent selection well respect social influences process
oncotype dxa breast recurrence score assay validated predict breast cancer recurrence adjuvant chemotherapy benefit select patients lymph node positive hormone receptor positive negative assessed year specific survival bcss patients results seer databases population based study cases seer registries diagnosed linked results assays performed genomic health primary analysis included patients diagnosed including micrometastases per seer negative per pcr primary invasive bcss assessed category number positive lymph nodes calculated using actuarial method proportion patients results disease increased time decreased increasing lymph node involvement micrometastases aeyen lymph nodes five year bcss outcomes ranged micrometastases aeyen lymph nodes similar patterns found patients aeyen group strongly predictive bcss among patients micrometastases three positive lymph nodes overall year bcss excellent patients micrometastases one two positive lymph nodes worsens additionally involved lymph nodes analyses account treatment variables longitudinal updates important better characterize utilization oncotype testing long term survival outcomes
detection embolic sources patients atrial fibrillation important guide anticoagulant therapy two dimensional transesophageal echocardiography tee gold standard study left atrial appendage laa anatomy morphology despite false positive diagnosis hypothesized real time tee rtdtee superior dtee detecting excluding laa thrombi studied patients non valvular males age years referred electric cardioversion transthoracic dtee rtdtee cardioversion tte allowed confident measurement emptying velocity laa laaev patients contrary good quality tee laaev obtained patients dysfunctional laa laaev subgroup patients effective cardioversion presented persistent dysfunction cardioversion laaev values tee post tee allowed observe bilobed shape patients three lobes patients addition besides several additional findings dtee managed detect thrombi certainty patients cases diagnostic doubts thrombi dtee patients addition rtdtee mode allowed discriminate certainty presence pectinate muscles patients rtdtee patients risk embolism feasible accurate showed additional diagnostic capability differential diagnosis selected cases suspected laa thrombi
steel proposed container material electrorefining process pyrochemical reprocessing spent metallic fuels future sodium cooled fast breeder reactors electrorefining process carried using licl kcl ucl molten salt electrolyte degrees argon atmosphere protect electrorefining vessel made steel attack electrolyte yttria stabilized zirconia ysz ceramic coating deposited steel thermal spray process corrosion behavior steel without ysz coating evaluated licl kcl ucl molten salt degrees argon atmosphere various durations results revealed increase exposure time weight loss uncoated steel samples increased ysz coated steel samples exhibited insignificant weight loss sem examination exposed uncoated steel samples showed depletion surface formation chromium based oxides corrosion products corrosion experiment sem eds xrd analyses coated uncoated samples showed presence
metabolic pathways engineered maximize synthesis various products interest advent computational systems biology endeavour usually carried silico theoretical studies aim guide complement vitro vivo experimental efforts clearly counts result vivo terms maximal productivity also robustness environmental perturbations engineering organism towards increased production flux however often compromises robustness contribution review investigate various analytical approaches used metabolic engineering synthetic biology related concepts developed systems control engineering trade offs production optimality cellular robustness already studied diagnostically statically dynamics also matter integration dynamic design aspects control engineering diagnostic aspects metabolic hierarchical control regulation analysis leading new conceptual operational framework required design robust productive dynamic pathways
propose turning light turn hot emotional system across six studies show ambient brightness makes people feel warmer increases intensity affective response including sensation seeking spicy hot foods perception aggression sexiness hotness others generating extreme affective reactions toward positive negative words drinks suggest effects arise light underlies perception heat perception heat trigger hot emotional system thus turning light effortless unassuming may seem reduce emotionality everyday decisions take place bright light society consumer psychology published elsevier inc rights reserved
renewable energy sources including hydropower wind biomass geothermal tidal wave solar energy sources satisfy present future energy demands minor environmental impact respect traditional sources energy solar energy cheapest widely available renewable energy solar cooling systems green cold production technology produce minor emissions due use heat pumps infect absorption refrigeration mature technology proved applicability possibility driven low grade solar energy contest thermal storage systems contribute balance disadvantages intermittent nature solar energy variation cooling demand receiving attention researchers recent years paper presents innovative comprehensive literature review solar systems integrated environmental friendly processes absorption heat pumps thermal energy storages study processes regarding renewable sustainable energy according european policy carried photovoltaic photovoltaic thermal solar systems used purpose promising technologies growing fast recent years researches show one half two effect absorption heat pumps integrated solar systems thermal energy storages attractive alternative cooling systems meeting demands energy conservation environmental protection showing various systems discussion improvement cooling applications respecting environment also presented paper
introduction treatment medial tibiofemoral osteoarthritis high tibial osteotomy hto effective optimal angular correction achieved however conventional instrumentation limited multiplanar correction needed hypothesis use patient specific cutting guides pscgs hto provides accurate correction difference relative preoperative planning materials methods february february patients mean age years range grade osteoarthritis ahlback classification included prospectively reliability safety study patients operated using medial opening wedge osteotomy technique preoperative planning based long leg radiographs scans reconstruction psgcs used align osteotomy cut position screw holes plate desired correction achieved three planes holes plate aligned holes drilled based pscg preoperatively mean hka angle degrees range degrees mean proximal tibial angle degrees degrees mean tibial slope degrees degrees postoperative correction compared planned correction using scan transformations intraoperative postoperative complications assessed minimum follow year results procedure successfully carried patients pscgs postoperative long leg radiographs mean hka degrees degrees scan mean tibial mechanical angle degrees degrees mean tibial slope degrees postoperative hka slope measurements difference planned achieved correction based analysis three planes space case slope instead planned intra class correlation coefficients postoperative planned parameters degrees degrees hka degrees degrees tibial slope surgical site infections one patient postoperative hematoma resolved spontaneously discussion results study showed use pscgs hto procedures helps achieve optimal correction safe reliable manner elsevier masson sas rights reserved
background aims aims study investigate proportion clinical irritable bowel syndrome ibs tertiary hospital china compare rome iii rome criteria regard ibs diagnosis describe agreement rome iii rome criteria identify differences rome positive negative ibs patients methods cross sectional survey performed among outpatients gastrointestinal department tertiary hospital patients categorized ibs using rome iii rome criteria results total patients completed symptom questionnaire among suspected ibs diagnosed ibs using rome iii rome criteria particular patients diagnosed ibs using rome iii criteria patients diagnosed using rome criteria rome ibs patients experienced pain symptoms showed higher ibs severity scores contrast significant differences noted demographic characteristics stool frequency ibs subtype disease course operation history infection history rome ibs patients ibs patients diagnosed rome criteria conclusions rome positive ibs patients represented approximately half rome iii positive ibs patients tertiary hospital china specifically rome positive ibs mainly subgroup rome iii positive ibs serious symptoms
paper deals sliding mode observer smo sensorless control induction motor drive anti windup proportional integral awpi speed controller using speed controller output variables saturated wind phenomenon unstable response often occur especially sensorless electric motor drive order improve high performance smo sensorless vector controlled induction motor drive use anti windup action included controller inner speed loop proposed scheme implemented digital signal processor dsp using dspace controller board experimental results presented show effectiveness algorithm smoothly stably response
full surround augmented reality augmentations spanning entire human field view beyond explored topic since currently hardware support current displays support relatively small fields view applications date employ relatively small point based annotations physical world anticipating change capabilities experiment wide field view annotations link elements far apart visual field built system uses full surround virtual reality simulate augmented reality different field views without tracking artifacts conducted study comparing user performance five different task groups within information seeking scenario comparing two different fields view presence absence tracking artifacts constrained field view significantly increased task completion time found indications task time effects tracking artifacts vary depending age
purpose assess clinical validity visual field archetypal analysis previously developed machine learning method decomposing humphrey weighted sum clinically recognizable loss patterns materials methods previously identified loss patterns archetypes denoted screened reliable vfs select representative patients whose vfs highest decomposition coefficients archetype global indices patient ocular demographic features extracted retrospectively based resemblances archetypes clinically observed patterns hypotheses generated associations certain archetypes clinical features association central island representing severe loss large cup disk ratio cdr distributions selected clinical features compared representative eyes certain archetypes eyes using two tailed test fisher exact test results eyes patients included representative cdr often among eyes representative central island inferior arcuate defect superior paracentral defect inferior paracentral defect eyes cdr often among eyes representative focal defect superior defect also associated ptosis conclusions shared clinical features computationally derived archetypes clinically observed patterns support clinical validity archetypal analysis
study applies multispectral band ratios examine vegetation density vegetation health assess drought conditions nearly years tuy phong district binh thuan province vietnam using sequence landsat imagery oli research area distinctive climate characterized arid semiarid areas adjacent binh thuan coastline drought likely intensified rain shadow effects central highlands part truong son annamese cordillera positioned immediately west province seasonal land surface temperature lst normalized difference vegetation index ndvi calculated derive three indices vegetation condition index vci temperature condition index tci vegetation health index vhi results show approximately two thirds tuy phong district influenced mid severe drought dry season november following april severity drought increased intensively extensively toward north hypotheses testing correlation lst ndvi also revealed significantly negative relationship increasing surface temperature decreasing ndvi validate results applied procedure generating vhi modis data despite absence historical datasets region landsat data shows many advantages monitoring drought remote small areas compared modis research strategies may effective regions without sufficient climatic records conventional climatic analysis
due network alarm data cloud environment characteristics massive redundancy relevance etc traditional growth algorithm memory computing time double bottleneck therefore paper presents improved growth algorithm based sharing path scans cube instead multiple scans entire database adopting structured storage alarm data model sharing path reduce recursive operations using mapreduce framework parallel computing experimental results show algorithm high efficiency good scalability reliability also identify relationship device alarm condition occurs reduce duplication alarms provide basis equipment maintenance network management
background overview meeting explore ways expand access oral health care seniors possibly expanding dental benefit medicare convened arlington santa group four factors motivated meeting need older americans fastest growing segment population medicare excludes dental care retirees lack dental insurance growth social capital groups outside dentistry already working expand access voiced strong support collective action moral imperative agreed senior experience pain poor diet loss self esteem inability pay oral health care improved health economic savings private insurers discovered significant net savings achievable general health costs dental care provided people certain systemic diseases practical implications model medicare dental benefit presented generated much discussion agreement dental benefit must attract participating dentists agreement also reached importance public demonstration projects establish cost savings dental care patients comorbid diseases need collaborate nondental advocacy policy groups establish overall health benefits seniors gained adding oral health care necessity oral health literacy campaigns working directly community level general public others including educators media well policy makers providers health fields levels professional training
osteoporotic femur fractures common fragility fracture account approximately one million injuries per year local intervention intra marrow injection potentially good choice preventing osteoporotic bone loss osteoporotic femoral fracture treated previously shown trace element doped calcium phosphate tecap implants could stimulate osteoporotic bone marrow mesenchymal stem cell activity vitro bone regeneration femoral bone defects osteoporotic animal models hypothesized local intra marrow injection tecap particles could improve bone function tecap sustain release biologically essential inorganic minerals improve bone remodeling osteoporosis tecap cap particles synthesized simulated body fluid without adding silicon zinc strontium ions female rats months ovariectomized ovx sham operated intervened femoral marrow space months old groups include saline water cap particles tecap particles months intervention sham groups showed higher bone mineral density mbd femur tecap group increased bmd ovx groups compressive strength ovx tecap group significantly higher ovx cap group significant differences ovx tecap ovx cap groups found bone mineral microarchitecture bone mineral density trace mineral content feces composition results confirm tecap particles could suppress osteoporotic bone loss local intramarrow injection therefore biomaterial could used next generation combination treatment osteoporotic trauma osteoporosis wiley periodicals inc
passenger travel comfort important analyzing vibration control quarter car model achieve various control strategies employed researchers degree freedom dof quarter car model analyzed travel comfort passenger designing simulating pid controller fuzzy logic controller flc dof quarter car integrated seat suspension driver model testing performance controllers system subjected four types road disturbance individually responses compared along passive system results show flc increases ride quality better pid passive system
fracture assessment tool frax widely used predicting fractures better methods needed aim study determine whether visual assessments mandibular trabecular bone could improve frax predictions three age cohorts women examined twice women women participated examinations information fracture events available bone trabeculation assessed radiographs dense mixed sparse fracture assessment tool values without bone mineral density bmd calculated twice sparse trabeculation frax associated twofold higher risk future fracture younger group three fourfold higher risk future fracture older group frax sparse trabeculation relative risk fracture next younger group older group either frax sparse trabeculation present younger group older group concluded frax without bmd measurements effective fracture predictor mandibular sparse trabeculation substantial additive effect together frax plus mandibular sparse trabeculation predicts major osteoporotic fractures approximately extent frax bmd measurements
study aimed developing optimization approach rainwater harvesting rwh considering three water consumption scenarios wcs scenarios include basic water need bwn pour flush full plumbing connection fpc corresponding litres per capita per day lpcd lpcd lpcd respectively simulated different categories buildings reliability supply determined first obtaining composite surplus deficit rainwater followed optimizing redistribution surplus rainwater harvested deficient buildings results showed total annual rainfall intercepted roof exceeded total demand reliability water supply guaranteed reliability found linear function storage reliability supply possible optimized storage bears inverse exponential relationship roof plan area per capita relationship surplus deficit roof plan area per capita follows one phase decay pattern optimal redistribution surplus water self sufficient buildings deficient ones gave improvement supply reliability basic water need pour flush full plumbing connection
objective describe degree perceived fertility control associated likelihood unintended pregnancy poor pregnancy outcomes among women report intimate partner violence design cross sectional cohort study design setting five domestic violence shelters one district attorney office large urban metropolis united states participants total women reported intimate partner violence reached first time shelter district attorney office assistance methods year prospective longitudinal study began participants overarching study interviewed every months month interview period participants responded one time investigator developed fertility control questionnaire addition ongoing repeated measures results almost one third participants reported least one unintended pregnancy attributed abusers refusal use birth control participants reported least one unintended pregnancy result abusers refusal allow use birth control participants times likely abuse induced miscarriages pregnancies resulted abusers use birth control finally participants times likely report premature births abused use birth control conclusion women abusive relationships reported compromised fertility control associated abuse increased risk unintended pregnancy well adverse pregnancy outcomes premature birth miscarriage
article explore different roles knowledge sharing exploitative learning play employees innovative behaviour investigate different moderating effects employees espoused national cultural values relationship exploitative learning innovative behaviour chinese enabled global service firms different ownerships propose theoretical model characterize antecedents innovative behaviour structured research survey conducted data collected sample full time employees enabled global service firms prc results indicate knowledge sharing positively associated innovative behaviour multinational corporations private enabled global service espoused power distance significant positive moderating effect exploitative learning innovative behaviour relationship state owned private firms espoused collectivism significant moderating effect state owned firms china last explore implications findings theory practice innovation
study magnetic graphite nanocomposite core shell structure prepared chemical vapor deposition cvd process adsorptive removal anionic dyes aqueous solutions characterized xrd hrtem haadf stem ftir raman spectroscopy bet zeta potential measurements applied adsorption two kinds anionic dyes acid red direct orange effect parameters like initial dye concentration solution temperature degrees adsorption process studied pseudo first order pseudo second order kinetic models intraparticle diffusion model used describe kinetic data kinetic study indicated pseudo second order model agreed well experimental data experimental data analyzed langmuir freundlich adsorption models adsorption equilibrium studies showed adsorption followed langmuir model thermodynamic parameters gibbs free energy delta degrees enthalpy delta degrees entropy delta degrees also obtained analyzed elsevier inc rights reserved
summary cannabis use rising usa relationship cannabinoid signaling bone cells implies use could affect bone mineral density bmd population national survey people ages found association self reported cannabis use bmd hip spine introduction cannabis widely used illegal drug usa recreational use recently approved several states cannabinoids play role bone homeostasis aimed determine association cannabis use bmd adults methods national health nutrition examination survey participants years old history cannabis use categorized never former previous use last days light days use last days heavy days use last days multivariable linear regression used test association cannabis use dxa bmd proximal femur lumbar spine adjustment age sex bmi race ethnicity among bmd determinants results sixty percent population reported ever using cannabis former users light users heavy users heavy cannabis users likely male lower bmi increased daily alcohol intake increased tobacco pack years andweremore likely used illegal drugs cocaine heroin methamphetamines association cannabis bmd observed level use conclusions history cannabis use although highly prevalent related risk factors low bmd independently associated bmd cross sectional study american men women
investigate potential involvement fertility treatments conditions becoming pregnant infertility getting pregnant birth control maternal history fetal loss folic acid supplements etiology childhood leukemia estelle study included cases cases acute lymphoblastic leukemia acute myeloblastic leukemia aml diagnosed france population controls frequency matched cases age gender data obtained structured telephone questionnaires administered mothers odds ratios confidence intervals estimated using unconditional regression models adjusted potential confounders associated difficulty becoming pregnant vitro fertilisation use fertility treatment index pregnancy significantly associated becoming pregnant contraception positive association observed third generation oral contraception however result based small numbers folic acid supplementation pregnancy associated inverse borderline association observed supplementation initiated months preceding pregnancy addition maternal histories stillbirth miscarriage associated aml respectively findings suggest infertility fertility treatments risk factors suggest maternal histories stillbirth miscarriage may frequent among mothers cases folic acid supplementation preconception may reduce risk
architects around world search new forms buildings many interesting shapes derived geometry theory surfaces among minimal surfaces discovered heinrich scherk deserve special attention due esthetical values one kind turns especially suitable shaping facades tall buildings present paper makes use weierstrass enneper parameterization construct surfaces explicit formulae selected surfaces implemented symbolic computation software upon exporting models cad system one obtains possibility designing sketches ready use engineering practice authors published elsevier ltd
background dendritic cell derived immunoglobulin domain molecule tim plays critical role initiation helper polarization vitamin vitd involves regulation number immune responses objectives study tests hypothesis vitd regulates tim expression dcs methods peripheral blood samples collected patients allergic rhinitis healthy subjects dcs isolated samples analyzed expression tim results observed levels calcitriol active form vitd sera patients lower healthy subjects peripheral expressed higher levels tim lower levels vdr negative correlation identified data serum calcitriol tim dcs exposure dcs calcitriol culture increased expression vdr also found vdr bound tim promoter locus dcs repress tim gene transcription expression conclusions clinical relevance vitd deficiency may contribute pathogenesis increasing tim expression results suggest regulate serum calcitriol levels expression vdr dcs may necessary taken account treatment
graphics processing units gpus widely used embedded systems manipulating computer graphics even general purpose computation however many embedded systems manage highly restricted hardware resources order achieve high performance energy efficiency number registers one common limiting factors embedded gpu design programs run low number registers may suffer high register pressure register allocation properly designed especially gpu register divided four elements element accessed separately allocating register vector type variable contain values elements wastes register spaces article present vector aware register allocation framework improve register utilization shader architectures framework involves two major components element based register allocation allocates registers based element requirement variables register packing rearranges elements registers order increase number contiguous free elements thereby keeping live variables registers experimental results cycle approximate simulator showed proposed framework decreased register spills total made common shader programs spill free results indicate opportunity energy management space used storing spilled variables framework improving performance geometric mean general shader processors variables spilled memory cycle access latencies respectively furthermore reduction register requirement programs enabled another programs high register pressure runnable lightweight gpu
intrusion detection system using honeypot increasingly used technique intrusion detection recovery data disrupted intruders paper presents survey intrusion detection system different honeypot techniques mostly useful identify zero day phishing attack listed table focus basic ideas based network security tools firewalls ids ids using honeypots honeytokens plays important role finding source attack types attack provide result signature attack investigators prevent kind attacks future
background maternal thyroid disease may complicate pregnancy high frequency abnormal thyroid function test results pregnant women known thyroid disease reported frequency unidentified thyroid dysfunction women first clinically diagnosed thyroid disease pregnancy known methods population based study pregnant women danish national birth cohort dnbc blood sample drawn early pregnancy terminated pregnancy singleton live birth period participants women dnbc registration thyroid disease five years pregnancy nationwide health registers random sample women cohort thyrotropin free thyroxine measured immunoassay sera stored danish national biobank method pregnancy week specific references ranges used classification thyroid function test abnormalities results frequency abnormal thyroid function early pregnancy random sample among women clinically diagnosed thyroid disease blood sampling among women current treatment one third women clinically diagnosed thyroid disease blood sampling unidentified thyroid dysfunction early pregnancy blood sample frequently unidentified hypothyroidism women later diagnosis hypothyroidism conclusions danish pregnant women current treatment thyroid disease thyrotropin free thyroxine outside week specific reference ranges frequency unidentified early pregnancy thyroid dysfunction women clinically diagnosed pregnancy also high
background published human studies investigating whether use allopurinol commonly used medication treatment hyperuricemia gout common type inflammatory arthritis adults beneficial effects ventricular electrophysiology objective study assess whether allopurinol use associated reduction risk ventricular arrhythmias methods used random sample medicare beneficiaries examine new allopurinol use risk incident multivariable cox regression analyses adjusted demographics age race sex comorbidity cardiac medications conditions associated calculated hazard ratios confidence intervals results episodes new allopurinol use associated incident among patients incident male white gout underlying diagnosis mean charlson romano comorbidity score crude incidence per person days declined duration allopurinol use increased days days years years multivariableadjusted analyses compared non use allopurinol use associated lower compared allopurinol non use longer allopurinol use durations significantly associated lower multivariable adjusted days days years years multiple sensitivity analyses adjusting cardiac conditions anti arrhythmic drugs alternate definitions confirmed findings minimal attenuation estimates conclusion allopurinol use use duration months independently associated lower risk future studies need assess pathophysiology potential benefit
significant public health disparities exist surrounding teen unplanned pregnancy united states women color lower education socioeconomic status much greater risk unplanned pregnancy resulting adverse outcomes unplanned pregnancies reduce educational career opportunities may contribute socioeconomic deprivation widening income disparities long acting reversible contraception larc including intrauterine devices implants offer opportunity change default drifting parenthood planned conception larc methods forgettable placed offer highly effective long term pregnancy prevention increasing evidence medical literature demonstrates population benefits use methods however barriers widespread use larc methods persist include educational access cost barriers increasing insurance coverage affordable care act widespread cost coverage methods women choosing intrauterine devices contraceptive implant increasing use highly effective contraceptive methods may provide one solution persistent problem health disparities unplanned teen pregnancies united states improve women children health
knn algorithm remains popular choice pattern classification till date due non parametric nature easy implementation fact classification error bounded twice bayes error paper show performance knn classifier improves significantly use training class wise group statistics based two criteria pairwise comparison features given dataset granger causality employed assign preferences criteria analytic hierarchy process ahp applied obtain weights different features two criteria preferences finally weights used build weighted distance function knn classification comprehensive experimentation fifteen benchmark datasets uci machine learning repository clearly reveals supremacy proposed granger causality driven ahp induced knn algorithm icnn method many different distance metrics various feature selection strategies addition proposed method also shown perform well high dimensional face hand writing recognition datasets
suicidal behavior difficulty regulating emotions hallmarks borderline personality disorder bpd study examined neural links emotion regulation suicide risk bpd individuals bpd female mean age years attempted suicide completed fmri task involving recalling aversive personal memories distance trials assessed ability regulate emotion recalling memories third person objective viewpoint immerse trials assessed emotional reactivity involved recalling memories first person perspective behaviorally groups reported less negative affect distance compared immerse trials neurally two sets findings obtained first reflected differences attempters non attempters immersing distancing attempters showed elevated recruitment lateral orbitofrontal cortex brain region implicated using negative cues guide behavior distancing attempters showed diminished recruitment precuneus region implicated memory recall perspective taking second set findings related individual differences regulation success degree individuals used distancing reduce negative affect observed attempters successfully regulated exhibited precuneus recruitment similar non attempters data provide insight mechanisms underlying suicide attempts bpd future work may examine findings generalize diagnoses also whether prior findings bpd differ across attempters non attempters elsevier ltd rights reserved
paper presents results centrifuge tests performed investigate behavior geotextile reinforced soil walls beyond stress conditions models built using nonwoven fabrics reinforcement layers dry sand backfill digital image analysis techniques used determine displacement sand markers placed along reinforcements models loaded failure increasing centrifugal acceleration movements sand markers used determine strain distributions along reinforcement layers results revealed stresses redistribute among reinforcement layers models approach failure current design methods grs walls found conservative applied predict behavior reduced scale models
word association tasks seek measure implicit attitudes participants may unwilling unable express explicitly analyzing timing responses sequence word matching tasks earlier study used computer based sequence word associations measure differences response time pair word associations categories within pairings realigned found females implicitly demonstrated negative attitude toward mathematics identified male gender domain male counterparts since females continue represented high paying math intensive career important educators informed research may lead improving participation women study mathematics study seeks identify patterns implicit female attitudes mathematics math gender identity based culture background growth environment current physical location results total sample consistent earlier studies significant variations observed subgroups partitioned culture background growth environment identifying types patterns may elucidate paths alter persistent lack female participation math intensive careers
reaction equilibria play important role chemical engineering calculated substance properties compounds involved reaction since substance properties usually come measurements always uncertainty uncertainty input data causes uncertainty simulation results even model perfect effect input uncertainty uncertainty equilibrium calculations studied monte carlo sampling applied accessing uncertainty probability density distribution uncertainty equilibrium conversion high however shape curve equilibrium conversion temperature predicted precisely consequence simulations reaction equilibria still useful temperatures required achieving certain conversion determined comparatively high accuracy probability density distributions obtained equilibria strongly deviate input data cases even become bimodal elsevier rights reserved
paper algorithm based subspace method moesp mimo ouput erreur state space family presented state space identification continuous time fractional commensurate models using samples frequency data compared rational state space representation commensurate differentiation order must estimated besides state space matrices estimated conventional subspacebased techniques using singular value decomposition first method developed multi input multi output system identification fractional models frequency domain
systematic design method grid multiscroll chaotic attractors using staircase nonlinear functions snfs proposed paper equations parameters grid multiscroll chaotic attractors derived consideration dynamic range active device number multiscroll chaotic attractors grid multiscroll chaotic attractors generated method chaotic circuit designed using current feedback operational amplifiers cfoas circuit consists three integrators two nonlinear circuits parameters circuit calculated parameters grid multiscroll chaotic attractors circuit generate grid multiscroll chaotic attractors central frequency circuit higher fewer active devices simpler circuit construction good frequency characteristic port characteristic cfoa numerical simulation results circuit simulation results show method feasible designed circuit correct
background common site fractures patients ankylosing spondylitis cervical spine especially lower cervical spine cervicothoracic junction optimal treatment cervical spine fractures secondary controversial study aimed explore effects posterior pedicle screw fixation alone fractures lower cervical spine patients methods january january total patients lower cervical spine fracture treated using posterior cervical thoracic pedicle screw fixation retrospective study reviewed patients charts assess case histories operations neurological outcomes complications also evaluated postoperative radiographs determine time bone fusion results altogether fractures resulted acute injury chronic injury cases fracture resulted low energy spinal injury cases high energy injury posterior pedicle screw fixation successful patients radiographic fusion confirmed computed tomography average time bone fusion months range months surgery improved american spinal injury association grade patients intraoperative complications occurred none corrections resulted neurological decompensation average postoperative correction degrees conclusions pedicle screw fixation autologous bone grafting single posterior approach lower cervical spine fractures patients could stabilize spine correct kyphosis relieve pressure thus reasonable recommend surgical strategy associated fractures lower cervical spine
unity diversity latin eugenic narratives europe article discusses development latin eugenics europe special focus france belgium italy spain romania period latin eugenics offered progressive programme social medical reform alongside pronatalist campaigns educate population importance large healthy families latin eugenics premised number theories ideas developed since early particularly france italy including puericulture biotypology opposition birth control compulsory sterilization nazi racism considering current revival eugenic studies across europe elsewhere important engage eugenic traditions ones recurrently invoked scholarship history latin eugenics europe provides much needed revision conventional interpretations eugenics focused predominantly anglo american german experiences
article focused construction bim based schedule management system construction industry system exerts bim advantages visualization collaboration management construction schedule management bim model subdivided meet management demand construction phase linking subdivided model time parameters visual manage construction schedule achieved system provided paper enables project participants join schedule management visualization models workers could get corresponding information effectively enhance control project schedule management
repeat surgery restenosis initial nonsyndromic craniosynostosis intervention sometimes needed calvarial vault reconstruction healed surgical bed adds level intraoperative complexity may benefit preoperative intraoperative definitions biometric aesthetic norms computer assisted design manufacturing using imaging allows precise formulation operative plans anticipation surgical intervention printing turns virtual plans anatomical replicas templates customized implants using variety materials authors present technical note illustrating use technology repeat calvarial vault reconstruction planned executed using computer assisted design printed intraoperative guides
study series laboratory experiments performed firstly analyze characteristics pore structure low rank coal poor development mesopores fractal features adsorbed pores seepage pores defined calculated using fractal dimensions respectively positive correlation moisture content positive correlation fixed carbon negative correlation volatile content weaker association ash yield apparent relationship coal macerals indicating coal forming materials environments little influence pore structure fractal characteristics strongly correlation bet surface area average pore diameter proving used characterize pore structure fractal dimension adsorbed pores shows negative correlation langmuir volume apparent relationship langmuir pressure indicating pore structure absorbed pores little effect methane desorption process cbm exploitation weak positive correlation permeability overall fractal analysis beneficial better understanding pore structure methane adsorbability seepage ability low rank coal elsevier ltd rights reserved
scale investment projects increases manufacturing project integrated risk management becomes important content relationship integrated risk manufacturing management framework discussed paper framework composed five parts integration risk management targets total life cycle processes methods organization information system different phase total life cycle depending risk management information system project risk management organization form virtue team promotes risk management loop composed risk identification risk evaluation risk handling risk monitoring iehm achieve project targets integrated risk management framework presented systematic method framework provides basis development integrated risk management
improve constant output voltage accuracy primary side controlled flyback converter study described digital control scheme based accurate sampling cable voltage drop compensation voltage drops output diode cable analysed first two important factors influence accuracy output voltage accurate sampling method eliminate voltage drop output diode proposed output current estimating digital resistance capacitance filter compensation cable voltage drop also designed finally software simulation prototype test results verified proposed scheme constant voltage accuracy prototype achieved approximate
frontal alpha asymmetry proposed underlie balance approach withdrawal motivation associated individual affective style neurofeedback eeg frontal alpha asymmetry represents promising tool reduce negative affect although specific effects left right frontal activity approach withdrawal motivation still unclear present study employed neurofeedback training increase frontal alpha asymmetry right left order evaluate discrete changes alpha power left right sites well positive negative affect anxiety depression thirty two right handed females randomly assigned receive either neurofeedback frontal alpha asymmetry active control training group asymmetry group showed increase alpha asymmetry driven higher alpha right site well coherent reduction negative affect anxiety symptoms pre post training training specific modulation emerged positive affect depressive symptoms findings provide strong rationale use frontal alpha asymmetry neurofeedback reduction negative affect anxiety clinical settings elsevier ltd rights reserved
definitely robustness important feature control system must take account especially considering design usually based low order linear models represent whole controlled process problem include characteristic implies degradation system performance regard previous statement paper concerned design closed loop control system take account system performance load disturbance set point changes robustness variation controlled process characteristics aim achieve good balance multiple trade offs pid control design provided looks robustness increase allowing degradation system combined performance proposed approach complementary work presented arrieta vilanova simple pid tuning rules guaranteed robustness achievement ifac world congress ind eng chem res doi iec arrieta performance degradation driven pid controller design pid ifac conference advances pid control
backgroundangioedema occurs taking angiotensin converting enzyme ace inhibitors upper airway angioedema may potentially require endotracheal intubation cricothyrotomy usually unresponsive adrenaline bradykinin receptor antagonist icatibant proven effective treatment acute attacks hereditary angioedema also reported effective treatment angioedema associated ace inhibitors aimto describe use icatibant ace inhibitor associated airway angioedema methodswe treated consecutive emergency department patients improved adrenaline corticosteroids icatibant subcutaneously ace inhibitor associated upper respiratory tract angioedema according agreed protocol resultsfour patients intubated either receiving icatibant three extubated within treatment eight patients received early icatibant require intubation time onset airway angioedema presentation ranged days median presentation receiving icatibant minutes days median onset symptom improvement icatibant minutes median one patient received second dose icatibant conclusionall patients improved receiving icatibant consistent bradykinin receptor blocking mechanism icatibant rapidly reversed symptoms appeared avert need intubation expedite extubation timely use icatibant ace inhibitor associated angioedema may avert need invasive airway procedures intensive care unit admission
detection moving objects video captured freely moving camera challenging problem computer vision existing methods often assume background approximated dominant single plane multiple planes impose significant geometric constraints utilize complex foreground probabilistic model instead propose computationally efficient algorithm able detect moving objects accurately robustly general scene problem formulated coarse fine thresholding scheme particle trajectories video sequence first coarse foreground cfg region extracted performing reduced singular value decomposition multiple matrices built bundles particle trajectories next motion pixels cfg region reconstructed fast inpainting method subtracting motion fine foreground segmented adaptive thresholding method capable solving multiple moving objects scenarios finally detected foreground refined mean shift segmentation method extensive simulations comparison state art methods verify effectiveness proposed method
incremental computation broadly applied computer software field needs complex algorithm design tough software maintenance develop xquery incremental computation program automatic generation method according characteristics xquery language method implement program transformation generate incremental computation program code automatically light input data modification computation obtain new result based original one execution performance incremental computation program better recomputation
neuroblastoma predominantly characterised chromosomal rearrangements next myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog mycn amplification chromosome gains frequently observed identified neuroblastoma patient regional gain encompassing enhancer zeste homologue ezh gene ezh histone methyltransferase lysine histone hkme forms catalytic subunit polycomb repressive complex hkme commonly associated silencing genes involved cellular processes cell cycle regulation cellular differentiation cancer high ezh expression correlated poor prognosis overall survival independent mycn amplification status unexpectedly treatment ezh high expressing neuroblastoma cell lines imr chp nmb ezh specific inhibitors gsk epz resulted slight arrest despite maximum histone methyltransferase activity inhibition furthermore colony formation cell lines treated inhibitors reduced concentrations much higher necessary complete inhibition ezh histone methyltransferase activity knockdown complete protein three independent shrnas resulted strong apoptotic response decreased cyclin levels apoptotic response could rescued overexpressing ezhaset truncated form wild type ezh lacking set transactivation domain necessary histone methyltransferase activity findings suggest high ezh expression least neuroblastoma survival function independent methyltransferase activity important finding highlights need studies ezh beyond methyltransferase function requirement compounds target ezh complete protein elsevier ltd rights reserved
although vitamin exhibits inhibitory effects viability hepatoma cells hepatoma cells insensitive therefore investigation attempt enhance sensitivity hepatoma cells results showed acted synergistically ethanol etoh inhibit viability smmc cells mainly cytochrome cype activated etoh synergistic effect etoh also observed qgy cells also express cype however hepg cells express cype synergistic effect etoh observed addition demonstrated cype could induced via post transcriptional transcriptional mechanisms results suggest induction cype enhance inhibitory effect viability hepatoma cells cype may attractive target enhanced antitumor effects hepatocellular carcinoma treatment
objective aim present study determine effect imparting planned health education climacteric women beliefs related hot flushes quality life methods research conducted using pretest post test semi experimental models along control group women randomly selected invited participate study five people agree participate study three people also excluded study complete training research sample comprised climacteric women women experimental group women control group years average ages participants experimental group years control group years experienced hot flushes within past month going menopause postmenopause using hormone replacement therapy agreed participate study participants asked complete sociodemographic questionnaire hot flush beliefs scale menopause specific quality life questionnaire three educational sessions week intervals given women experimental group research supported educational booklet prepared researchers training given women control group education experimental group months women groups recompleted data collection forms post test data collected results subscales total hot flush beliefs scale average post test score women experimental group scored lower women control group average post test total score experimental group control group women experimental group developed positive beliefs hot flushes beliefs women control group remained unchanged average post test score subscales menopause specific quality life questionnaire women experimental group lower women control group average post test score experimental group vasomotor subscale psychosocial subscale physical subscale sexual subscale average post test score control group vasomotor subscale psychosocial subscale physical subscale sexual subscale quality life women experimental group showed upward trend women control group remained conclusion found planned health education climacteric period reduced women negative beliefs hot flushes enhanced quality life
two players wishing communicate placed room telephones connecting two rooms players know telephones interconnected round player picks phone says hello hear problem devise algorithm minimising delay establish communication problem called telephone coordination game also termed telephone problem fundamental importance distributed algorithm design paper investigate generalised version among telephones subset establish communication two players interested devising deterministic strategy achieving bounded rendezvous delay minimising worst case rendezvous delay specifically first establish lower bound worst case rendezvous delay characterise structure phone pick sequences guarantee rendezvous without prior coordination assuming player globally unique devise deterministic strategy guarantees rendezvous players regardless telephone labeling functions relative time difference approaches performance bound within constant factor proportional length
purpose reviewmicrobial dysbiosis receiving increasing attention possibly important pathophysiology irritable bowel syndrome review summarize recent literature addressing attempts explore target microbiome patients irritable bowel syndrome recent findingsmanipulation intestinal microbiota irritable bowel syndrome receiving increasing attention traditionally dietary manipulation utilized evidence low fermentable oligosaccharides disaccharides monosaccharides polyols diet able improve symptoms may effect gut microbiota probiotics safe attractive option manipulation microbiota number well designed trials examining efficacy certain strains bacteria even yeasts receiving attention role antibiotics remains controversial seems likely use currently limited individuals small intestinal bacterial overgrowth interest role faecal microbiota transplantation treatment number gastrointestinal conditions intensified irritable bowel syndrome exception summarythe manipulation microbial dysbiosis gaining momentum research however required order identify appropriate treatment option individual patient
background neuroimaging immunologic pharmacologic studies emphasized role hta hta serotonin receptors pathophysiology major depression aim aim study measure relative expression hta hta receptor mrna peripheral blood mononuclear cells pbmcs patients major depressive disorder mdd method hta hta receptor mrna expressions examined pbmcs medication naive patients mdd medication free mdd patients healthy controls hta hta receptor mrna expressions measured using real time quantitative pcr study evaluated patients clinical symptoms using hamilton depression rating scale items hdrs beck depression inventory bdi results relative htra mrna expression significantly higher pbmcs mdd patients compared healthy controls mdd patients showed significant correlations htra mrna expression hdrs scores bdi scores conclusion study showed depressed patients irrespective treatment higher htra mrna levels pbmcs healthy subjects also provided evidence htra mrna levels pbmcs mdd patients could associated severity depression duration illness
examined different kinds rating formats interaction purposes rating administrative developmental induced different performance rating processes consequences rating accuracy two experiments participants rated seven targets presented via videotapes using modes rating giving access descriptive knowledge rating scales target observable behaviors descriptive behavior evaluative knowledge rating scales others behaviors target tended afford evaluative behavior mix two knowledge types rating scales traits indexes discriminability within ratee discriminability accuracy differential elevation differential accuracy collected results showed rating scales led higher ratee discriminability differential elevation modes rating whereas rating scales led higher within ratee discriminability modes results indicate rating scales suited comparing different ratees administrative purpose rating whereas scales suited identifying strengths weaknesses particular ratee developmental purpose experiments first apply dual knowledge descriptive evaluative theory performance appraisal context examine rating purpose interaction two forms person knowledge results consistent theoretical predictions indicate using rating scales different types content function rating purpose produce appropriate performance ratings
last decade witnessed proliferation neuroimaging studies characterising brain changes associated alzheimer disease widespread atrophy signature brain regions implicated parallel prolonged latency period established abnormal cerebral changes beginning many years symptom onset raises possibility early therapeutic intervention even symptoms treatments could greatest effect disease course modification two important prerequisites endeavour accurate characterisation risk stratification monitoring progression using neuroimaging outcomes surrogate biomarker without symptoms develop referred preclinical structural neuroimaging modalities used identify brain changes related risk factors familial genetic mutations risk genes example apolipoprotein epsilon allele family history review summarise structural imaging findings preclinical overall literature suggests early vulnerability characteristic regions medial temporal lobe structures precuneus well white matter tracts fornix cingulum corpus callosum conclude structural markers promising research validation studies needed future secondary prevention trials adopt structural imaging biomarkers either stratification surrogate biomarkers elsevier rights reserved
improved proportional integral derivative pid controller based predictive functional control pfc proposed tested chamber pressure industrial coke furnace proposed design motivated fact pid controllers industrial processes time delay may achieve desired control performance unavoidable model plant mismatches model predictive control mpc suitable situations paper pid control pfc algorithm combined form new pid controller basic characteristic pfc algorithm time simple structure traditional pid controller proposed controller tested terms set point tracking disturbance rejection obtained results showed proposed controller better ensemble performance compared traditional pid controllers isa published elsevier ltd rights reserved
facilitating fish passage fragmented river systems commonly focused commercially important migratory species salmonids increasingly ecosystem based approaches river rehabilitation adopted fishways progressively designed fish assemblages estuarine barriers fish movement received less attention riverine barriers regards refinement fish passage study evaluated fish passage pair hydraulically distinct vertical slot fishways large vertical slot max velocity max turbulence discharge small vertical slot max velocity max turbulence discharge low level estuarine barrier terminus river murray australia paired day samples fishway entrances exits fish species sampled large vertical slot compared fish species small vertical slot small bodied fish large bodied species rare fishways species composition similar species specific abundances varied widely fishways large vertical slot successfully passed broad range species sizes passage several small bodied length species partially obstructed whilst passage efficiency high species entered small vertical slot fishway variation head differential subsequently fishway hydraulics influenced number fish sampled entrance small vertical slot number fish sampled exit large vertical slot unison however fishways facilitated passage diverse migratory fish assemblage across range head differential experienced suggesting application paired vertical slot fishways differing hydraulic characteristics likely viable approach low level estuarine barriers elsevier rights reserved
study conducted compare effects administration coconut oil moringa oleifera oil testicular oxidative stress sperm quality steroidogenesis parameters rats treated mercury chloride hgcl days oral administration body weight body weight along intraperitoneal administration hgcl body weight alone combination found treatment protect hgcl induced poor sperm quality motility count well decreased testosterone level beta hydroxysteroid dehydrogenase beta hsd activity treatment alone decreased glutathione gsh glutathione peroxidase gsh activities increased malondialdehyde mda level rat testis whereas change parameters cotreatment prevented hgcl induced testicular catalase cat superoxide dismutase sod activities poor sperm quality low testosterone level also blocks adverse effect hgcl body weight body weight investigated endpoints conclusion decreased deleterious effects hgcl sperm quality steroidogenesis rats also strengthen antioxidant defence testes therefore beneficial antioxidant hgcl induced oxidative damage
background malfunctioning serotonergic system parkinson disease may contribute non motor symptoms respiratory complications thus aim study investigate role serotonin receptors modulation normoxic breathing hypoxic ventilatory response hvr rat model parkinson disease methods wistar rats lesioned unilaterally double hydroxydopamine ohda injection right medial forebrain bundle mfb lesion two weeks later animals put whole body plethysmography chamber exposed hypoxia hypoxic tests animals received intraperitoneal injections doi ketanserin efficacy lesion confirmed cylinder test assessing limb use asymmetry results degeneration nigrostriatal pathway augmented response tidal volume minute ventilation hypoxia doi administration control lesion state caused significant rise normoxic respiratory rate minute ventilation yet ventilatory response parameters hypoxia attenuated post doi magnitude hvr lesioned state decreased compare pre lesion control subsequent ketanserin injection reverted doi induced respiratory effects demonstrated ohda treatment decreased content serotonin injured striatum sides brainstem leaving concentration noradrenaline unchanged level conclusions observations showed damage nigrostriatal system initiates changes serotonergic system confirmed reduced concentration serotonin striatum brainstem affects magnitude respiratory response hypoxia activation receptors
control based continuation technique tracking solutions bifurcations nonlinear experiments idea apply method numerical continuation feedback controlled physical experiment control becomes non invasive since experiment generally possible set state system directly control target becomes proxy state control based continuation enables systematic investigation bifurcation structure physical system much like numerical model however stability information hence bifurcation detection classification readily available due presence stabilising feedback control paper uses periodic auto regressive model exogenous inputs arx approximate time varying linearisation experiment around particular periodic orbit thus providing missing stability information method demonstrated using physical nonlinear tuned mass damper authors published elsevier ltd open access article license
background westernized lifestyle blamed allergy epidemics one characteristics increased distances frequency travelling early life onwards early life travelling places substantially differ home environment terms climate vegetation food could increase exposure unknown allergens hence promote development allergies epidemiological study investigated speculation methods detailed data travelling first years life well range atopic outcomes along potential confounders age years collected prospectively within two large population based multicentre german birth cohorts giniplus lisaplus farthest travelling destination within germany middle northern eastern europe southern europe outside europe total number trips combination considered exposures six atopic outcomes used doctordiagnosed asthma doctor diagnosed allergic rhinitis nose eye symptoms sensitization food allergens sensitization indoor outdoor inhalant allergens longitudinal associations exposure health outcome pair analysed using generalized estimation equations gees results results longitudinal analyses subjects support research hypothesis travelling abroad different regions europe beyond europe frequency travelling increase prevalence doctor diagnosed asthma allergic rhinitis nose eye symptoms allergic sensitization years age furthermore indication age varying effects conclusions early life travelling seem increase risk atopic outcomes nevertheless could account type visited environment length stay first findings interpreted caution
individuals often hold ambivalent attitudes positive negative attitudes time toward groups social categories aim present research examine differential effects affective cognitive dimensions ambivalence amplification responses towards minority group asked students university perugia read short description fictitious group immigrants expressing affective cognitive attitudes toward target group participants received positive negative supplementary information group discrimination assessed asking participants allocate target group percentage financial support fund poor people italian immigrant living regional area expected found affective ambivalence amplified either negative positive responses toward group
delaying retirement age become international trend recent years worsening situation china population aging ongoing implementation birth control policy scale china economic workforce decelerated pressure national pension payment increased last two years delaying retirement age become cynosure society implementation faced many difficulties essay seeks apply labor measurement indices reference bases participation rate labor force ratio aging population working population dependency ratio draws conclusion china current retirement age system fails accommodate demand growing labor force market therefore delaying retirement age indispensable
iron deficiency continues prevalent micronutrient deficit worldwide since iron involved several processes including myelination dopamine neurotransmission neuronal metabolism presence iron deficiency anemia ida infancy relates long lasting neurofunctional effects scarce data regarding whether effects would extend former iron deficient anemic human adults resting state functional magnetic resonance imaging fmri novel technique explore patterns functional connectivity default mode network dmn one resting state networks deeply involved memory social cognition self referential processes four core regions consistently identified dmn medial prefrontal cortex posterior cingulate retrosplenial cortex left right inferior parietal cortex therefore investigate dmn former iron deficient anemic adults particularly useful approach elucidate long term effects functional brain conducted research explore connection ida infancy altered patterns resting state brain functional networks young adults resting state fmri studies performed participants belong follow study since infancy participants former iron deficient anemic infancy controls mean age years males resting state fmri protocol used data analyzed using seed based connectivity statistical analysis assess dmn found compared controls former iron deficient anemic subjects showed posterior dmn decreased connectivity left posterior cingulate cortex pcc whereas exhibited increased anterior dmn connectivity right pcc differences groups also apparent left medial frontal gyrus former iron deficient anemic participants increased connectivity areas included dmn dorsal attention networks preliminary results suggest different patterns functional connectivity former iron deficient anemic control young adults indeed ida infancy common nutritional problem among human infants may turn important understanding mechanisms cognitive alterations common adulthood
research positive emotion disturbance gained increasing attention yet clear specific positive emotions affected mood symptoms particularly critical period adolescence especially pertinent identifying potential endophenotypic markers associated mood disorder onset course present study examined self reported discrete positive negative emotions association clinician rated manic depressive mood symptoms clinically demographically diverse group outpatient adolescents years age results indicated higher self reported joy contempt associated increased symptoms mania controlling symptoms depression low levels joy high sadness uniquely predicted symptoms depression controlling symptoms mania results independent age ethnicity gender bipolar diagnosis findings extend work specific emotions implicated mood pathology adulthood provide insights associations emotions associated goal driven behavior manic depressive mood symptom severity adolescence particular joy emotion associated depressive manic symptoms across adolescent psychopathology highlighting importance understanding positive emotion disturbance adolescent development
proposed sensorless model control based static model equation converter able change bias value corresponding changes load current input voltage output voltage sensorless model control regulate output voltage hand transient response output voltage improved therefore improvement transient response carried adding transient improvement function changes bias value drastically short time start transient state purpose paper indicate parameter setting transient improvement function improves transient response simulation analysis changing circuit condition
general systematic formulation based finite element method modified nodal analysis multi field system approach presented analysis multiple magnetic field systems electrically interconnected circuit networks frequency domain approach permits simultaneous solution number cartesian axisymmetric problems considering electrical terminals finite element model nonnatural elements modified nodal analysis allowing systematic incorporation global system equations way arbitrary electrical network topologies readily analyzed magnetic systems simple elements circuit system moreover unified building block introduced axisymmetric models leading easy computer implementation effectiveness formulation tested determining electromagnetic behavior double squirrel cage induction motor connected three feeding transformers cartesian finite element model employed three phase motor whereas axisymmetric representation used transformer hence four finite element models simultaneously solved electrically coupled circuit elements lumped circuit parameters model end effects motor squirrel cage stator well associated stator feeding circuits previous work considers coupling cartesian systems formulation expands capabilities quasi finite element modeling systematically coupling axisymmetric finite element models
paper handles proposed algorithm surface air anti stealth technology homeland security paper approach anti stealth theory application using fuzzy logic control anti stealth done exposing stealth wave absorber non lethal pulsed yag electric permittivity enhanced consequently reflection application surface air done determining important parameters borders range creating virtual shape laser beam hunter target expecting degree freedom free space fuzzy logic control control proposed system inserting expected range laser hunter beams finally desired angle obtained get contact points surface visible microwave radar
increased obesity rates evolving food supply overconsumption energy dense foods led increase research exploring addictive eating behaviours study aimed investigate food addiction sample australian adults using revised yale food addiction survey yfas tool associated dietary intake personality traits mental health issues australian adults invited complete online survey collected information including demographics dietary intake depression anxiety stress personality dimensions including impulsivity sensation seeking hopelessness anxiety sensitivity total individuals recruited samples comprising female mean age years range years body mass index bmi food addiction identified participants using yfas tool classified severity food addiction mild cases moderate severe cases predictors severe food addiction female gender odds ratio higher levels soft drink confectionary consumption anxiety sensitivity overall people severe extremely severe depressive symptoms range highest odds severe food addiction variable reduced odds severe food addiction vegetable intake current study highlights addictive food behaviours associated complex pattern poor dietary choices clustering mental health issues particularly depression
one widely used resources electricity however electrical network serious issue uniform distribution electricity paper investigates distributed generation systems electrical network proposes interdisciplinary mechanism effective sharing electricity across electrical sub network proposed mechanism based wireless mesh network micro controller proposed system forms wireless mesh network used exchange information current status predicted status electricity generators mesh nodes wmn information mesh node used micro controller drive electrical devices micro controller responsible controlling direction flow electricity quantity electricity permitted particular part electrical network
aerodynamic aeroelastic flutter driven triboelectric nanogenerators successfully used harvest broadband airflow energy unit component flutter membrane consists thin free standing foil electrodes covered sides electrospun poly vinyl chloride nanofiber structured mats provide advantageous tribo surfaces specifically increase friction area airflow induced triboelectric power generation single unit flutter membrane based triboelectric nanogenerator teng mild airflow condition use multi layered triboelectric nanogenerator fabricated simply stacking single units improve output performance device separate configuration designed novel teng structure mounting aeroelastic flutter belt adapted use fluttermembrane energy harvester rubber belt sandwiched flutter membranes created rapid periodic vibrational mode via aeroelastic fluttering synergistically harvesting triboelectric energy application constant air stream closed channel teng thus flutter membranebased approach creates sustainable cost efficient energy harvesting system collecting broadband airflow energy furthermore aerodynamic aeroelastic teng great potential used numerous areas self powered electronic systems situ wireless sensor applications automobiles aircraft
background early relationships infant care takers significant emotional interactions relationships play important role forming personality adulthood relationships objectives current study aimed investigate relationship attachment styles emotional intelligence marital satisfaction materials methods cross sectional research married people male female selected using multistage sampling method mashhad iran subjects completed attachment styles questionnaire asq bar emotional quotient inventory enrich marital satisfaction questionnaire results results indicated secure attachment style positive significant relationship marital satisfaction also avoidant attachment style ambivalent attachment style negative significant relationship marital satisfaction also attachment styles significantly predict marital satisfaction therefore emotional intelligence components positive significant relationship marital satisfaction thus emotional intelligence intrapersonal adaptability general mood components significantly predict marital satisfaction conclusions according obtained results attachment styles emotional intelligence key factors marital satisfaction decrease marital disagreement increase positive interactions couples
oxytocin vasopressin related systems present invertebrate vertebrate bilaterian animals including humans exhibit conserved neuroanatomical functional properties vertebrates systems innervate conserved neural networks regulate social learning behavior including conspecific recognition social attachment parental behavior individual species level variation central organization oxytocin vasopressin systems linked individual species variation social learning behavior humans genetic polymorphisms genes encoding oxytocin vasopressin peptides respective target receptors associated individual variation social recognition social attachment phenotypes parental behavior psychiatric phenotypes autism describe conserved variable features central oxytocin vasopressin systems context social behavioral diversity particular focus neural networks modulate social learning behavior salience sociosensory stimuli species typical social contexts published elsevier ltd
background metamemory describes monitoring knowledge one memory capabilities patients schizophrenia found less able differentiating correct false answers smaller confidence gap asked provide retrospective confidence ratings previous studies furthermore higher proportions high confident false responses found patient group high knowledge corruption whether biases contribute early pathogenesis psychosis yet unclear study thus aimed investigating metamemory function early course psychosis method patients risk mental state psychosis arms patients first episode psychosis fep healthy controls hcs compared verbal recognition task combined retrospective confidence level ratings results fep patients showed smallest confidence gap followed arms patients followed hcs groups differed significantly regarding knowledge corruption fep patients differed significantly hcs whereas statistical trend revealed comparison arms fep groups correlations revealed metamemory measures positive symptoms working memory performance conclusions data underline presence metamemory bias arms patients even pronounced fep patients bias might represent early cognitive marker beginning psychotic state longitudinal studies needed unravel whether metacognitive deficits predict transition psychosis evaluate therapeutic interventions
tunneling radiation particles black holes lovelock born infeld lbi gravity studied using parikh wilczek method emission rate particle calculated shown emission spectrum deviates purely thermal spectrum consistent underlying unitary theory compared conventional tunneling rate related increment black hole entropy entropy black hole lbi gravity obtained entropy obey area law unless lovelock coefficients equal zero satisfies first law thermodynamics accordance earlier results distinctly shown tunneling framework related thermodynamic laws black hole
multiscale modeling method newly introduced research cable anchorage systems self anchored suspension bridges steel box girders improve reliability conventional modeling methods two kinds boundary conditions bcs hard bcs flexible bcs defined illustrated strategy modeling method cable anchorage system multiscale analysis introduced based proposed strategy multiscale model cable anchorage system developed taohuayu bridge largest self anchored suspension bridge world comparison scale model test carried two elaborate finite element models including traditional scale model full scale model established according traditional scale modeling method full scale modeling method validation full scale whole bridge elaborate model established determined full scale model test complex stress distribution anchor structure newly observed intensive comparison study various models demonstrates fuzzy region exists test model scale model full scale model caused use assumption hard bcs saint venant principle fuzzy region quantitatively determined leading unreliable analysis results large amount trial error work multiscale model complex bcs cable anchorage system accurately simulated flexible bcs influence fuzzy region eliminated results multiscale model matches well full scale model concluded multiscale modeling method suitable modeling method simulate mechanical behaviors cable anchorage system self anchored bridges steel box girders reliably efficiently american society civil engineers
morphological profiles mps efficiently exploited modelling geometrical features structures scene increase discriminability different classes degree processing images depends geometrical structure shape used structure element transformation since geometric structures image whole image use fixed shape may efficient thus proposed extract edge patch image based morphological profile epimp considers ses different shapes different areas image used patch image corresponding shape edge image patch proposed method experimented multispectral hyperspectral images obtained results show proposed method much efficient conventional mps moreover experiments show superiority epimp compared state art spectral spatial classification methods generalised composite kernel multiple feature learning weighted joint collaborative representation multiple structure element non linear multiple kernel learning
stilbenes valuable phenolic compounds synthesized plants via phenylpropanoid pathway stilbene synthase sts directly catalyzes resveratrol pinosylvin formation currently lack information stilbene biosynthetic pathway spruce picea resveratrol piceatannol derivatives detected spruce bark needles roots analyzed seasonal variation stilbene spectrum content needles different ages one tree spruce picea jezoensis hplc analysis revealed presence nine stilbenes cis astringin cis piceid cis isorhapontin piceatannol present amounts dry weight isorhapontigenin resveratrol present traces astringin prevailed stilbenoid compounds stilbenes highest total stilbene content detected one year old needles collected autumn spring previously cloned sequenced full length cdnas four sts transcripts pjsts pjstsb pjss pjsts jezoensis study presents detailed analysis seasonal variations pjsts transcript levels needles jezoensis different ages using qrt pcr pjstsa pjsts transcription higher needles collected autumn spring summer winter pjsts actively transcribed needles ages collected winter spring summer pjsts expression significantly change year depend age needles therefore data show high levels stilbene glucosides pjsts expression present needles jezoensis elsevier ltd rights reserved
aim crohn disease chronic mucosal inflammation affects intestinal barrier function example altering intestinal permeability pilot clinical study investigated impact oral human immunoglobulin ohig treatment permeability characteristics children active luminal crohn disease methods study performed department paediatrics norrkoping hospital sweden intestinal permeability studied three boys aged years active six week treatment programme ohig using different sized polyethylene glycols test molecules three age sex matched children active treated exclusive enteral nutrition een also studied results ohig een resulted virtually similar reductions signs symptoms mucosal inflammation however ohig unlike een appeared normalise mucosal transfer leading normalisation maximum permeation small peg molecules well less restrictions larger peg molecules conclusion study found ohig appeared normalise mucosal barrier suggests could offer new additional versatile treatment paediatric patients minimal risk adverse effects
dicyanoisophorone based probe two photon absorption nir emission developed vivo fluorescence imaging amyloid beta plaques exhibited high selectivity toward beta aggregates intracellular proteins detection limit calculated low vivo imaging studies indicated probe could penetrate blood brain barrier label beta plaques living transgenic mice specific binding cerebral beta plaques confirmed one two photon vivo fluorescence imaging results featured promising application prospects amyloid beta sensing basic research biomedical research elsevier rights reserved
background purpose detection aquaporin igg aqp igg critical diagnostic criterion neuromyelitis optica spectrum disorder nmosd evaluate serostatus nmosd patients based new diagnostic criteria using new house cell based assay cba methods generated stable cell line using internal ribosome entry site containing bidstronic vectors allow simultaneous expression two proteins aqp green fluorescent protein separately rna transcript performed house cba using serum patients nmosd patients diagnosed according new diagnostic criteria without aqp igg high risk nmosd patients presenting core clinical characteristics nmosd fulfilling dissemination space patients neurological diseases including multiple sclerosis serostatus definite high risk nmosd patients also tested using commercial cba kit identical serum evaluate correlation methods assays performed two independent blinded investigators results house assay yielded specificity sensitivities detecting definite high risk nmosd patients respectively comparison commercial cba kit revealed correlation patients correlation present patients seronegative using commercial method seropositive using house method patients seropositive using commercial method seronegative using house method conclusions results demonstrate house cba highly specific sensitive method detecting aqp igg nmosd patients
ultrasonic measurement method developed use characterizing thin surface layer property changes develops polymeric materials exposed long term high temperature environments method involves creating rayleigh surface wave wavelength similar size depth degraded layer similar microns since typical wedge transducers incapable generating rayleigh waves polymers mediator wedge transducer method designed effectively serve line source ultrasonic wave high resolution noncontact signal detection accomplished use laser vibrometer order adequately provide data automated calculations velocity attenuation successive events wave generation detection analog signal processing simulated measurements epoxy specimen explicit finite element method representative mathematical post processing algorithms order better understand measurements application usefulness comparison preliminary simulation data experimental measurements provides useful insights data patterns detected experiments
september women workers kannan devan hills plantation large tea estate munnar kerala launched spontaneous agitation demanding increased wages bonuses staged massive sit munnar town bringing operations tea estate halt unique strike garnered considerable domestic media attention non violent nature distancing party affiliated tea plantation unions paper use interview transcripts community radio program analyze whether strike seen precursor new unionism great mass contractual informal workers india within broader question whether class identity still relevant informal labor global south conclude successful working class movement emerge workers understand roles long convoluted chain profits able universalize situations concrete political action
paper presents new strategy online robust control based fractional order pid controller fpid technique suggests online parameters tuning fpid using fictitious reference iterative tuning frit approach approach enables track desired optimal fpid parameters online using experimental data without plant model identification set optimal non integer orders gains fpid estimated recursive manner using called recursive least squares rlss algorithm forgetting factor cope variation plant characteristics adaptively performances technique compared results already existing literature typical examples results proposed approach show significant performance improvement
paper presents research done towards goal achieving automatic flight control commercial airliners formation flight motivation research ultimately reduce fuel consumption reduction drag follower aircraft result formation flight traditional aerodynamic equations conventional flight fixed wing aircraft expanded include formation flight interactions trim analysis uncovers risks challenges feasible trim regions formation follower maintain regions include potentially risky region sandwiched two untrimmable regions respect maximum aileron setting outside region one untrimmable bound making less risky lower fuel consumption benefit next state space representation constructed allowing linear dynamics analysis poles movement function lateral vertical separation follower aircraft relative leader aircraft shown indicate greater changes flight dynamics due vertical separation lateral separation results trim analysis linear dynamics analysis form basis design formation flight control system
optimal function water distribution network reached consumer demands satisfied using lowest quantity energy maintaining minimal pressure required time one way achieve optimization flow rate injection based use setpoint curve concept order obtain methodology proposed allows assessment flow rate pressure head pumping station provide proper functioning network minimum power consumption kept methodology addressed two ways discrete method continuous method first method finite set combinations evaluated pumping stations continuous method search optimal solution performed using optimization algorithms paper hooke jeeves nelder mead algorithms used hydraulics objective function used optimization solved epanet toolkit two case studies evaluated results application different methods discussed
background spacing permanent birth control methods need hour popularity male sterilization vasectomy low compared female sterilization tubectomy however safe effective cheap less surgical complications scalpel vasectomy nsv emerging good option aims study various demographic behavioural factors nsv acceptors setting design institution based retrospective study conducted department obstetrics gynaecology medical college kolkata time period april march methods material patients accepted nsv family planning analysed respect age residence occupation literacy number issues complications statistical analysis data represented simple proportions percentages graphs using micro soft excel results sterilization operations vasectomies tubectomies couples selected sterilization contraception tubectomies accounted times vasectomies number nsvs percentage total sterilizations rising gradually falling clients years age educated primary education accepted nsv however illiterate acceptors labourers last years trend nsv child conclusion nsv emerging socially culturally acceptable method contraception society
bacteria ubiquitous abundant atmosphere potential pathogens known cause diseases allergies humans however quantities compositions total airborne bacterial community relationships environmental factors remain poorly investigated case study total airborne bacteria collected six cities beijing tianjin hebei bth megalopolis china profiled using quantitative polymerase chain reaction qpcr illumina miseq sequencing qpcr results showed high abundance total airborne bacteria bth ranging cell air averaged cell air six samples classified three groups proteobacteria cyanobacteria actinobacteria firmicutes four dominant phyla common potential pathogens extremely low percentage observed dominated enterococcus faecium escherichia coli plants soil probably main sources bacteria suggested high percentages chloroplast plant associated bacteria rhizobiales sphingomonadales soil inhabiting bacteria burkholderiales pseudomonadales variation partitioning analysis vpa indicated atmospheric pollutants explained variation community structure followed meteorological conditions chemical compositions case study furthers understanding diversity composition airborne bacterial communities bth also identified main factors shaping bacterial communities
rounding education students advanced courses applied electromagnetics incumbent mentors raise issues encourage appreciation certain subtle aspects often overlooked first exposure field one interplay fields potentials latter often seen convenient mathematical artifice useful solving maxwell equations nonetheless practiced application well understood various alternatives use fields potentials available within electromagnetic theory definitions energy density momentum transfer stress energy tensor forth although various options compatible basic equations electrodynamics maxwell equations lorentz force law gauge invariance nonetheless certain alternative formulations lend seen preferable others regard transparency application physical problems interest argue transparency energy density power flux option based potentials alone
background positive psychological constructs optimism associated greater participation cardiac health behaviors improved cardiac outcomes positive psychology interventions target psychological wellbeing may represent promising approach improving health behaviors high risk cardiac patients however study assessed whether positive psychology intervention promote physical activity following acute coronary syndrome objective article describe methods novel factorial design study aid development positive psychology based intervention acute coronary syndrome patients aim provide preliminary feasibility data study implementation methods positive emotions acute coronary events iii study optimization study planned subsumed within larger multiphase optimization strategy iterative treatment development project goal positive emotions acute coronary events iii identify ideal components positive psychology based intervention improve post acute coronary syndrome physical activity using factorial design positive emotions acute coronary events iii aims evaluate relative merits using positive psychology exercises alone combined motivational interviewing assess whether weekly daily positive psychology exercise completion optimal determine utility booster sessions study primary outcome measure moderate vigorous physical activity weeks measured via accelerometer secondary outcome measures include psychological functional adherence related behavioral outcomes along metrics feasibility acceptability primary study outcome use mixed effects model random intercept account repeated measures assess main effects component inclusion motivational interviewing exercises duration intervention inclusion booster sessions full factorial model controlling baseline activity similar analyses performed self report measures objectively measured medication adherence weeks hypothesize combined positive psychology motivational interviewing intervention weekly exercises booster sessions associated superior physical activity results thus far participants enrolled possible exercises fully completed participants conclusion positive emotions acute coronary events iii study help determine optimal content intensity duration positive psychology intervention post acute coronary syndrome patients prior testing randomized trial study novel use factorial design within multiphase optimization strategy framework optimize behavioral intervention use positive psychology intervention promote physical activity high risk cardiac patients
recent socioeconomic changes created intensified paradoxical organizational tensions companies numerous industries including construction sector need address organizing managing activities nature tensions sufficiently explored existing construction management literature thus study analyzes tensions control flexibility different organizational interfaces perceived managers three large infrastructure projects parts two different megaprojects sweden empirical findings highlight several tensions within three types interfaces external intraorganizational interorganizational tensions important project managers project owners understand paper contributes project construction management literature illustrating importance systemic paradox perspective obtained combining paradox literature principal agent theory systemic paradox perspective required understand tensions control flexibility interpreted different parties tensions different organizational interfaces interrelated may addressed avoid suboptimization
glutathione transferases gsts enzymes involved detoxification several endogenous exogenous substances study evaluated effects two glutathione transferase polymorphisms gstm gstt bipolar disorder bpd risk susceptibility tunisian population polymorphisms analyzed healthy subjects patients bpd using polymerase chain reaction statistical analysis performed using spss relative associations gsts genotypes bpd assessed calculating odds ratios ors confidence intervals cls study results demonstrated individuals gstm gstt associated risk bpd whereas significant association found individuals gstm null genotype bpd risk genotyping finding revealed absence gstm gstt activity could contributor factor development bpd elsevier rights reserved
veridical false memories children aged years studied two experiments retrieval induced forgetting paradigm using deese roediger mcdermott drm false memory word lists children reports true false memories showed evidence retrieval induced forgetting differences observed across delays long days following word list presentation lack observation retrieval induced forgetting children false memories provides evidence key assumption theory retrieval induced forgetting cue independence might consistently apply experiments underscore need practical theoretically motivated study true false memories elsevier inc rights reserved
australian undergraduate programs implementing curriculum aimed better preparing graduates work culturally diverse settings remains uncertainty role extant student attitudes towards indigenous australians begin address obtained baseline data student attitudes upon entry tertiary education health science first year students males females completed anonymous class paper questionnaire average students reported positive attitudes towards indigenous australians female students reporting positive attitudes male domestic students positive international hierarchical multiple regression analyses indicated controlling demographic variables interactional diversity experiences attitudes accounted significant variance range measures preparedness work indigenous health contexts knowledge gained inform development alignment curriculum pedagogical approaches leading improved facilitation model educators indigenous studies context
work describes modern methods parallelizing time consuming problems commonly used parallelization methods openmp mpi gpus aimed accelerate solution electromagnetic forward problems revisited comparison technologies constraints benefits complex three dimensional geoelectromagnetic field modeling provided approach configure distributed computing system solve resource intensive geoelectromagnetic problems proposed problem load balancing computational nodes distributed computing system advantages disadvantages different task orchestration approaches considered different approaches building fault tolerant systems create reliable one capable carrying complex three dimensional time consuming problems discussed efficiency proposed method distributed computing shown example solving inverse problems geoelectromagnetic survey geoelectrical imaging medium complex structure structure conductivity three layers located different depths varying lateral depth thickness conductivity restored results computational experiments show high computational efficiency proposed system fault tolerance equipment failures errors computing software
purpose date studies addressed attitudes toward transgender individuals addition little known health care providers hcp attitudes toward sexual minorities aim present study compare attitudes toward homosexual transgender individuals gender dysphoric individuals gds general population controls hcp methods total subjects considered including gds transwomen transmen heterosexual hcp males females participants completed modern homophobia scale mhs attitudes toward transgendered individuals scale atti order assess attitudes toward gay men lesbian women toward transgender individuals respectively addition gds completed gender identity gender dysphoria questionnaire gidyq atti measure respectively gender dysphoria levels internalized transphobia religious attitudes evaluated means religious fundamentalism scale rfs discrimination stigma scale disc used measure perceived discrimination
advent nanotechnology increasingly influenced research fields covering also food area awareness peculiar properties matter nanoscale level stimulated investigations submicron less nanosize appealing possibility evidence interactions among nanostructures foodstuff strictly related functional organoleptic properties food besides common techniques known well advent nanotechnology light scattering electron microscopy nanoparticle tracking analysis nta come almost ten years ago although technique new basic principles rely well consolidated theoretical knowledge stokes einstein dynamic scattering equations aim review provide overview techniques commonly used characterize food structures focusing attention nta therefore literature survey provided taking account many different situations occur food products spanning emulsions protein aggregates individual nanoparticles either added improve food properties derived food contamination comparison nta classical dynamic light scattering dls also included focusing attention strength weakness techniques current increasing interest nta foreseen expand use also food area stimulating research perspective conscious food managing approach elsevier ltd rights reserved
paper dimensional nonlinear evolution equation generated via jaulent miodek hierarchy investigated based bell polynomials hirota method bilinear forms backlund transformations derived one two soliton solutions constructed via symbolic computation soliton solutions obtained backlund transformations get three types choosing different parameters kink bell shape anti bell shape solitons propagation one soliton elastic interactions two solitons discussed graphically interaction two bell shape anti bell shape solitons solitonic shapes amplitudes keep invariant except phase shifts interaction kink soliton anti bell shape soliton anti bell shape soliton turns bell shape one kink soliton keeps shape amplitudes unchanged
introduction gene environment interaction expression genotypes monoamine oxidase maoa adverse childhood experience increases risk antisocial behavior however neural underpinnings interaction remain uninvestigated cortico limbic circuit involving prefrontal cortex pfc amygdala central suppression aggressive impulses modulated serotonin maoa genotypes may modulate vulnerability circuit increase risk emotion regulation deficits specific life events acute tryptophan depletion atd challenges regulation may identify vulnerable neuronal circuits contributing gene environment interaction methods functional magnetic resonance imaging measured restingstate state activity healthy males double blind placebo controlled study cortical maps amygdala correlation identified impact atd interaction low maoa highexpression variants maoa maoa cortico limbic connectivity results across regions interest rois exhibiting atd effect cortico limbic connectivity maoa carriers susceptible atd maoa carriers particular maoa group exhibited larger reduction amygdala connectivity right prefrontal cortex larger increase amygdala connectivity insula dorsal pcc conclusion maoa carriers susceptable central challenge cortico limbic networks vulnerability cortical serotonergic system may contribute emergence antisocial behavior systemic challenges observed geneenvironment interaction wiley periodicals inc
inhaled oligonucleotide emerging therapeutic modality various common respiratory diseases including obstructive airway diseases like asthma chronic obstructive pulmonary disease copd restrictive airway diseases like idiopathic pulmonary fibrosis ipf advantage direct accessibility oligonucleotide molecules lung target sites bypassing systemic administration makes therapeutic approach promising minimized potential systemic side effects asthma copd ipf common chronic respiratory diseases characterized persistent airway inflammation dysregulated tissue repair remodeling although individual disease unique etiology corticosteroids widely prescribed treatment asthma copd ipf however effectiveness corticosteroids anti inflammatory drug limited steroid resistance severe asthma majority copd cases pulmonary fibrosis urgent medical need develop target specific drugs treatment respiratory conditions oligonucleotide therapies including antisense oligonucleotide aso small interfering rna sirna microrna mirna evaluated pre clinically clinically potential therapeutics mechanisms action aso sirna highly target mrna specific ultimately leading target protein knockdown mirna biomarker therapeutic values knockdown mirna antagonist antagomir broader potentially non specific biological outcome review compile current findings oligonucleotide therapeutic targets verified various respiratory disease models clinical trials evaluate different chemical modification approaches improve stability potency oligonucleotides treatment respiratory diseases
paper carries parameter analysis cable deflections gravity stiffness cable stayed suspension bridge previous studies given formulas cable deflections gravity stiffness according formulas three significant parameters examined rise span ratio concentrated load ratio cable stayed length whole span result indicates reasonable parameters selected gravity stiffness cable stayed suspension bridge improved greatly
patient specific algorithm epileptic seizure prediction based multiclass support vector machines svm using multi channel high dimensional feature sets presented feature sets combined multiclass classification post processing schemes aim generation alarms reduced influence false positives study considers patients european epilepsy database includes patients scalp eeg recordings intracranial data strategy tested total inter ictal data including seizures found overall sensitivity false positive rate per hour performance method achieved statistical significance patients patients despite encouraging results previously reported specific datasets prospective demonstration long term eeg recording limited study presents prospective analysis large heterogeneous multicentric dataset statistical framework based conservative assumptions reflects realistic approach compared constrained datasets sample evaluations improvement results definition appropriate set features able improve distinction pre ictal nonpre ictal states hence minimizing effect confounding variables remains key aspect
adult bronchial asthma characterized chronic airway inflammation presents clinically variable airway narrowing wheezes dyspnea cough long standing asthma induces airway remodeling leading intractable asthma number patients asthma increased however number patients die asthma decreased per patients goal asthma treatment enable patients asthma attain normal pulmonary function lead normal life without symptoms good relationship physicians patients indispensable appropriate treatment long term management therapeutic agents elimination causes risk factors asthma fundamental treatment four steps pharmacotherapy differentiate mild intensive treatments step includes appropriate daily dose inhaled corticosteroid varying low high levels long acting beta agonists leukotriene receptor antagonists sustained release theophylline long acting muscarinic antagonist recommended add drugs anti immunoglobulin antibody oral steroids considered severe persistent asthma related allergic reactions bronchial thermoplasty recently developed severe persistent asthma long term efficacy known inhaled beta agonists aminophylline corticosteroids adrenaline oxygen therapy approaches used needed acute exacerbations choosing treatment steps asthma accordance severity exacerbations allergic rhinitis eosinophilic chronic rhinosinusitis eosinophilic otitis chronic obstructive pulmonary disease aspirin induced asthma pregnancy also important issues need considered asthma therapy copyright japanese society allergology production hosting elsevier
social attachment biological affective need need met people experience loneliness loneliness associated impaired social cognition risk factor broad based morbidity across adult lifespan even controlling multiple factors however little known loneliness schizophrenia eighty seven non depressed individuals schizophrenia schizoaffective disorder including inpatients control subjects completed revised ucla loneliness scale social cognition assessed self report questionnaire performance based task social trait perception assessed facial task comorbid medical diagnoses available inpatients patients reported greater loneliness levels controls patients significantly differ patients loneliness associated self report measures social cognition patients loneliness scores predicted diagnosis drug abuse dependence number drugs used hypertension abnormal hemoglobin levels patients experienced higher levels loneliness controls independently objective social isolation loneliness rely psychological processes patients controls loneliness schizophrenia symptom deserves scrutiny particularly relates high prevalence metabolic syndrome population
recent years online social networks become part everyday life millions individuals also data analysts found fertile field analyzing user behavior individual collective levels academic commercial reasons hand many risks user privacy information user may wish remain private becomes evident upon analysis however data anonymized make safe publication public domain information inevitably lost respect original version significant aspect social networks local neighborhood user associated data current anonymization techniques good identifying risks minimizing good maintaining local contextual data relate users social network thus improving aspect high impact data utility anonymized social networks also lack systems facilitate work data analyst anonymizing type data structures performing empirical experiments controlled manner different datasets hence present work address issues designing implementing sophisticated synthetic data generator together anonymization processor strict privacy guarantees takes account local neighborhood anonymizing done complex dataset fitted real dataset terms data profiles distributions empirical section perform experiments demonstrate scalability method improvement terms reduction information loss respect approaches consider local neighborhood context anonymizing elsevier ltd rights reserved
recently scientific communities produce growing number computation intensive applications calls interoperation distributed infrastructures including clouds grids private clusters european shiwa flow projects enabled combination heterogeneous scientific workflows execution large scale system consisting multiple distributed computing infrastructures one resource management challenges projects called parameter study job scheduling parameter study job workflow generally large number input files consumed independent job instances paper propose meta brokering framework science gateways support execution workflows order cope high uncertainty unpredictable load utilized distributed infrastructures introduce called resource priority services tools capable determining dynamically updating priorities available infrastructures selected job instances evaluations show approach implies efficient distribution job instances among available computing resources resulting shorter makespan parameter study workflows
traditionally challenging implement higher order pwm closed loop class audio amplifiers using analog intensive techniques deep submicron low voltage process technologies primarily attributed reduced power supply degraded analog transistor characteristics including short channel effects increased flicker noise random telegraph noise transistor reliability concerns passive component performance paper introduce global closed loop mixed signal architecture incorporating digital control integrate fourth order amplifier prototype cmos systematic approach analyze design compensate feedback loop digital domain also presented versatility implementing loop gain poles zeros digitally attains high gain throughout audio band attenuates residual high frequency ripples around loop simultaneously accomplishing improvements thd psrr overall architecture inherently amenable implementation deep submicron therefore compatible scaled cmos measured prototype achieves high dba snr thd psrr efficiency supplying emulated speaker load performance competitive conventional designs using large feature size precision cmos specialized bcd technologies reports highest output power deep submicron designs
diagnosis pulmonary actinomycosis difficult less cases diagnosed initial presentation actinomycosis always poly microbial flora infection human hand candida parapsilosis emerging fungal pathogen especially immuno compromised patients combined bacterial fungal infection increases frequency severity disease report case candida parapsilosis infection year old male patient pulmonary actinomycosis thereby could guide clinicians towards appropriate therapy
cartilaginous viscerocranium buffalo skull includes meckel cartilage derivatives malleus incus mandibular condyle reichert cartilage derivatives including stapes styloid process temporal tympanohyoid hyoid formation meckel cartilage recognized first days ossification cartilaginous viscerocranium appeared first stylohyoid days bone wise sequence appearance ossification cartilaginous viscerocranium stylohyoid malleus body cornua hyoid incus stapes
among agencies involved population control activities mid twentieth century none scored many early victories latin america pathfinder fund founded procter gamble scion clarence gamble article analyzes style delivery family planning assistance developing world work pathfinder fund peru organization hub south america shows pathfinder personnel collaborated local protestant institutions protestant allies helped pathfinder set manage rapid interventions production pamphlets smuggling contraceptives enrollment physicians advocates use intrauterine devices although rapid interventions helped quickly disseminate information certain technologies among fortunate also weakened legitimate state agencies neglected monitoring safety drugs supplied alienated allies high handed boldness
magnetorheological fluid kind typical smart material whose stability viscosity shear yield stress three important performance indexes study order acquire high performance fluid two kinds coated magnetic particles multiwalled carbon nanotubes mwcnts coated magnetic particles surfactant modified magnetic particles prepared performances density magnetic properties investigated group fluids based mixing coated magnetic particles different mixing ratios coated magnetic particles different volume fractions different dosages thixotropic agent experimented considering sedimentation stability rheological properties shear yield stress results show coated magnetic particles lower density relatively high saturation magnetization benefit antisettlement behavior fluids mixing ratio coated magnetic particles volume fractions dosage thixotropic agent effects properties fluids time initial tilt chain model fluids based mixing coated magnetic particles proposed describe properties fluids microlevel numerical values shear yield stress fit well experimental values
paper propose growing type fuzzy classifier gtfc online rule learning real time data streams batch rule learning training data assumed drawn stationary distribution online rule learning data dynamically change time becoming potentially nonstationary accommodate dynamic change gtfc relies new semi supervised online learning algorithm called growing gaussian mixture model particular used generate type fuzzy membership functions build type fuzzy rules gtfc designed accommodate data online reconcile labeled unlabeled data using self learning moreover gtfc maintains low complexity rule base using online optimization feature selection mechanisms gtfc tested data obtained ambient intelligence application goal exploit sensed data monitor living space behalf inhabitants sensors prone faults noise type fuzzy modeling suitable dealing application thus gtfc offers advantage dealing uncertainty addition self adaptation online manner illustration purposes gtfc also validated synthetic classic uci data sets detailed empirical study shows gtfc performs well various experimental settings
paper deals problem securing configuration phase internet things iot system main drawbacks current approaches focus specific techniques methods lack cross layer vision problem smart environment iot device limited resources often battery operated limited capabilities keyboard consequence network security must carefully analyzed order prevent security privacy issues paper analyze iot threats propose security framework device initialization show physical layer security effectively boost security iot systems
purpose retrospectively compare three dimensional ultrasonography pelvic rays assess position tubal sterilization microinserts material methods forty four patients underwent tubal sterilization essure microinserts institution included microinserts position evaluated three months procedure using pelvic rays placement binary categorized correct incorrect distance two devices reported orientation symmetric deployment microinserts distance proximal parts two devices assessed pelvic rays performance pelvic ray compared using mac nemar test comparison distance two devices measured pelvic rays made paired student test results images showed microinserts eighty six percent correctly positioned pelvic rays significant differences performances two imaging techniques found significant differences distance two devices measured pelvic ray found conclusion simple non ionizing technique appears promising alternate technique pelvic rays assess correct position essure microinserts editions francaises radiologie published elsevier masson sas rights reserved
precision diabetes medicine optimisation therapy using patient level biomarker data stimulated enormous interest throughout society provides hope effective less costly safer ways preventing treating perhaps even curing disease precision diabetes medicine often framed context pharmacotherapy using biomarkers personalise lifestyle recommendations intended lower type diabetes risk slow progression also conceivable least four ways might work helping predict person susceptibility adverse lifestyle exposures facilitating stratification type diabetes subclasses may prevented treated optimally specific lifestyle interventions aiding discovery prognostic biomarkers help guide timing intensity lifestyle interventions predicting treatment response review overview rationale precision diabetes medicine specifically relates lifestyle also scrutinise existing evidence discuss barriers germane research field consider work likely proceed
recent years exists low frequency oscillation lfo events high speed railway multiple electric motor units accessed traction network better deal problem paper regards vehicle grid system cascade system mathematical small signal model vehicle grid system established first norm stability criterion adopted analyze system stability considering impedance specification vehicles grid simulation results show lfo analyzed method presented paper addition effective improvement measure recommended restrain lfo vehicle grid system
independent component analysis ica one popular techniques analysis resting state fmri data several advantageous properties compared techniques notably contrast conventional seed based correlation analysis model free multivariate thus switching focus evaluating functional connectivity single brain regions identified priori evaluating brain connectivity terms brain resting state networks rsns simultaneously engage oscillatory activity furthermore typical seed based analysis characterizes rsns terms spatially distributed patterns correlation typically means simple pearson coefficients thereby confounds together amplitude information oscillatory activity noise ica regression techniques hand retain magnitude information therefore sensitive changes spatially distributed nature correlations differences spatial pattern shape well amplitude network activity furthermore motion mimic amplitude effects crucial use technique retains information ensure connectivity differences accurately localized work investigate dual regression approach frequently applied group ica assess group differences resting state functional connectivity brain networks show ignoring amplitude effects excessive motion corrupts connectivity maps results spurious connectivity differences also show implement dual regression retain amplitude information use dual regression outputs identify potential motion effects two key findings using technique retains magnitude information dual regression using strict motion criteria crucial controlling network amplitude motion related amplitude effects respectively resting state connectivity analyses illustrate concepts using realistic simulated resting state fmri data vivo data acquired healthy subjects patients bipolar disorder schizophrenia
urban rainwater reuse preserves water resources promotes sustainable development rapidly growing urban areas efficiency large number urban water reuse systems operating different climate demand conditions evaluated base new risk analysis approach results obtained probability analysis indicate maximum efficiency low demanding scenarios threshold distinguishing low high demanding scenarios indicates low demanding scenarios significant improvement performance may attained increasing storage capacity rainwater harvesting tanks threshold behaviour displayed tank storage capacity designed match average collected volume average reuse volume low demand limit achieved climate operating conditions characterized disproportion harvesting demand volume
purpose work describe possibility installation wave converter sicily mediterranean sea paper present design buoyant electrical generator particular wave linear permanent magnet generator make wave energy converted electrical energy
recently using compressive sensing cryptosystem drawn attention due compressibility low complexity sampling process however applying cryptosystem images protect privacy image keeping efficiency becomes challenge paper propose novel image coding scheme achieves combined compression encryption parallel compressive sensing framework sampling reconstruction performed parallel way efficiency guaranteed hand security resistance chosen plaintext attack cpa realized help cooperation nonlinear chaotic sensing matrix construction process counter mode operation furthermore defect energy information leakage based cryptosystem also overcome diffusion procedure experimental analysis results show scheme achieves effectiveness efficiency high security simultaneously elsevier inc rights reserved
background best available treatment seasonal affective disorder sad light therapy yet treatment prevent recurrence depression subsequent seasons aim study gain preliminary insight efficacy mindfulness based cognitive therapy mbct prevention sad recurrence methods randomized controlled pilot study sad patients remission randomly allocated individual format mbct control condition treatment usual mkt given may june presence depressive symptoms inventory depressive symplomatology self report ids patients received weekly basis september april used assess moment recurrence severity moment recurrence results sad patients randomized mkt control condition kaplan meier survival curve showed groups differ moment recurrence tests showed group difference mean ids scores moment recurrence limitations results limited small sample size missing data weekly ids assessments conclusion findings pilot rct suggest individual mbct effective preventing sad recurrence offered symptom free period spring elsevier rights reserved
behavioral disturbances common serious symptoms patients dementia currently fda approved drugs purpose case reports small case series use buspirone retrospective study review patients prescribed buspirone treatment behavioral disturbance dementia better characterize efficacy potential side effects patients prescribed buspirone behavioral disturbance due dementia geropsychiatric outreach program reviewed data collected analyzed using spss one hundred seventy nine patients met criteria study mean age alzheimer dementia common dementia followed mixed dementia vascular type behavioral disturbances mainly verbal aggression physical aggression using clinical global impression scale patients responded buspirone moderately markedly improved mean dose buspirone buspirone appears effective treating behavioral disturbances dementia future prospective double blinded studies needed
background although children autism spectrum disorder asd likely exposed harsh parental discipline research issue scarce particular studies examined risk factors harsh parental discipline population responded gap literature testing multiple individual environmental factors potential predictors parental psychological aggression physical assault toward children asd guided developmental ecological perspective hypothesized harsh parental discipline would shaped characteristics child symptom severity parent parenting stress family economic pressure broader context discrimination community method total hong kong parents children asd completed standardized questionnaires hypotheses tested using bivariate correlation multivariate regression analyses results bivariate level child symptom severity parenting stress family economic pressure experienced discrimination positively associated parental psychological aggression moreover child symptom severity parenting stress positively associated parental physical assault multivariate level parenting stress significantly related psychological aggression child symptom severity parenting stress significantly related physical assault mediation analyses demonstrated psychological aggression partially mediated effect parenting stress physical assault conclusions theoretically findings contributed understanding origin harsh parenting practices toward children asd practically findings provided insights ways identify high risk families develop effective child maltreatment intervention programs elsevier ltd rights reserved
understanding brains process sensory signals natural environments one key goals twenty first century neuroscience brain imaging invasive electrophysiology play key roles endeavor also important role played noninvasive macroscopic techniques high temporal resolution electro magnetoencephalography challenges exist determining best analyze complex time varying neural responses complex time varying multivariate natural sensory stimuli long history applying system identification techniques relate firing activity neurons complex sensory stimuli techniques seeing increased application eeg meg data one particular example involves fitting filter often referred temporal response function describes mapping feature sensory stimulus neural response first briefly review history system identification approaches describe specific technique deriving temporal response functions known regularized linear regression introduce new open source toolbox performing analysis describe used derive multivariate temporal response functions describing mapping stimulus response directions also explain importance regularizing analysis regularization optimized particular dataset outline specifically toolbox implements analyses provide several examples types results toolbox produce finally consider limitations toolbox opportunities future development application
aim paper prove global existence weak solutions angiogenesis model proposed tosin bull math biol model consists compressible navier stokes equations coupled reaction diffusion equation describing concentration chemical solution responsible endothelial cells migration blood vessels formation proofs based control entropy term associated entropy solution hyperbolic mass conservation equation adaptation results feireisl dynamics viscous compressible fluids oxford university press lions mathematical topics fluid mechanics vol compressible models oxford lecture series mathematics applications novotny straskhaba introduction theory compressible flow oxford university press inevitable models dealing compressible navier stokes equations use vanishing artificial viscosity method prove existence solution main difficulty passing limit lack compactness due hyperbolic equation usually induces resonance phenomenon overcome using concept compactness effective viscous pressure combined suitable renormalized solutions hyperbolic mass conservation equation
motor function assessments rating scales relation pharmacokinetics levodopa may increase understanding individualize fine tune treatments study aimed investigate pharmacokinetic profiles levodopa carbidopa motor function following single dose microtablet administration parkinson disease single center open label single dose study patients experiencing motor fluctuations patients received individual levodopa equivalent morning dose levodopa carbidopa microtablets blood samples collected pre specified time points patients video recorded motor function assessed six updrs part iii motor items dyskinesia score treatment response scale trs rated three blinded movement disorder specialists auc dose max dose levodopa found higher parkinson disease patients compared healthy subjects previous study respectively mean time maximum improvement sum six updrs items score min mean time trs score maximum effect min mean time onset dyskinesia min population following levodopa carbidopa microtablet administration fasting state max auc dose found higher compared results previous study young healthy subjects large subject variability response duration effect observed highlighting importance continuous individual assessment motor function order optimize treatment effect
water regarded poor absorber solar energy affects efficiency solar thermal systems addition nanoparticles heat transfer fluids used solar thermal systems enhance optical properties new generation heat transfer fluids known nanofluids present study investigates stability optical properties three nanofluids including aluminum oxide titanium dioxide nanofluids stability nanofluids observed photo capturing method zeta potential measurements ultraviolet visible vis spectrophotometer used measure absorbance transmittance prepared nanofluids effect factors type particle type surfactant solution optical properties nanofluids also investigated found titanium dioxide nanofluid better optical properties lower stability compared aluminum oxide nanofluids
low carbon sustainable development becomes important chinese even world author sorted logic green building technology logic digital technology generalizing development type modern green building technology specific experiment object xuzhou fenghua garden residential district planned designed though green digital design means reasonable general plan designed scientifically efficiently though immediate colorful chill sunshine time map repeated adjusted design prove efficiency possibility green digital design bring inspiration deeper level advanced algorithm
highly flexible continuum arms investigated thoroughly materials actuators employed include cables pneumatic muscles also shape memory alloys smas sma smart material applied continuum robot due intrinsic compliance elongate contract applying external forces return original shape given appropriate current however control sma actuated robot still challenge paper takes inspiration octopus neurophysiology designs hierarchical controller sma based continuum robotic arm
aim study explore variability hospital admissions patients spondyloarthritis spa spain centre factors may influence variability descriptive cross sectional study part emar study performed spain health records patients diagnosis spa least one visit rheumatology units within previous years reviewed variables related hospital admissions spa patient centre collected multilevel logistic regression analysis random intercept non random slopes performed assess variability centres centres patients health records reviewed main spa forms ankylosing spondylitis psoriatic arthritis total admissions registered patients adjusted variability hospitalizations centres noted following hospital related factors showed significant association admissions total number admissions centre existence electronic admission availability ultrasound rheumatology however factors explained inter centre variability risk patient spa admitted could double median depending hospital patient managed hospital admissions patients spa varied hospitals due centre characteristics studies needed ascertain specific factors may causing variation studied variables explained less half variability
paper presents electronically tunable versatile multifunction voltage mode biquadratic filter three inputs five outputs employing five operational transconductance amplifiers two grounded capacitors one grounded resistor use grounded capacitors makes circuit highly suitable integrated circuit implementation proposed filter simultaneously realize low pass band pass high pass band stop pass voltage responses appropriately connecting input output terminals natural frequency quality factor orthogonally controlled inverting type input signals required realizing filter responses incremental sensitivities low pspice simulation results given confirm presented theory
borderline personality disorder bpd display altered evaluations regarding reward punishment compared others processing rewards basal operant conditioning however studies addressing operant conditioning bpd patients rare current study operant conditioning task combining learning acquisition reversal used bpd patients matched healthy controls hcs exposed aversive neutral stimuli assess influence emotion learning picture content dissociation aversive tension symptom severity rated error rates measured results showed group interactions aversive versus neutral scenes higher emotional arousal dissociation tension worse acquisition riot reversal scores bpd patients scores borderline symptom list associated errors reversal acquisition phase results preliminary evidence impaired acquisition learning due increased emotional arousal dissociation tension bpd patients failure process punishment reversal phase associated symptom severity may related neuropsychological dysfunctioning involving ventromedial prefrontal cortex conclusions limited due correlational study design small sample size elsevier ireland ltd rights reserved
introduction hiv related stigma hampers treatment prevention efforts worldwide effective interventions counter hiv related stigma greatly needed although contact hypothesis suggests personal contact persons living hiv plhiv may reduce stigmatizing attitudes general population empirical evidence support hypothesis lacking aim estimate association personal contact plhiv hiv related stigma among general population sub saharan africa methods social distance anticipated stigma operationalized using standard hiv related stigma questions contained demographic health surveys aids indicator surveys african countries fitted multivariable logistic regression models country level fixed effects specifying social distance dependent variable personal contact plhiv primary explanatory variable interest results analyzed data women men living sub saharan african countries estimated statistically significant negative association personal contact plhiv desires social distance adjusted odds ratio aor confidence interval sensitivity analysis similar finding obtained model used community level variable personal contact plhiv aor conclusions personal contact plhiv associated reduced desires social distance among general population sub saharan africa contact interventions developed tested reduce stigma hiv
rotor diameter attached precision electric motor used generator make model wind turbine output power generator measured wind tunnel air velocity maximum power power conversion factor kinetic electric energy power law confirmed model illustrates several technically important features industrial wind turbines quantitatively
deliberation concepts father fatherhood literal symbolic meanings makes starting point paper furthermore short historical overview combined selected theories fatherhood serve framework placing issues regarding modern fatherhood appropriate context context concluded rests historical interdependence fatherhood masculine identity political power traditional determinants masculinity aggressiveness emotional detachment represent major obstacle fulfilling positive father child relationship relationship partially discussed relation concept equal parental partnership implying new forms fatherhood new forms masculine identity well unfortunately still many obstacles modern fatherhood important one gender inequality manifested traditional male bread winner female child nearer models subsequently data provided values practices croatian men women regarding childcare collected analysed part international social survey programme issp survey family changing gender roles arising conclusion although many positive changes made croatian society got long way equal parenting gender equality also important note subject political legal controversy fatherhood must considered independently wider gender issues regarding motherhood social status men women well socio economic assumptions fatherhood motherhood
rationale idiopathic pulmonary fibrosis ipf chronic fatal lung disease dismal prognosis cure potential role ubiquitously expressed domain containing tyrosine phosphatase shp therapeutic target studied ipf objectives determine expression mechanistic role potential therapeutic usefulness shp pulmonary fibrosis methods effects shp overexpression inhibition fibroblast response profibrotic stimuli analyzed vitro primary human mouse lung fibroblasts vivo therapeutic effects assessed bleomycin model lung fibrosis shp lentiviral administration transgenic mice carrying constitutively active shp mutation measurements main results shp regulated lungs lung fibroblasts obtained patients ipf immunolocalization studies revealed shp absent within fibroblastic foci loss shp expression activity sufficient induce fibroblast myofibroblast differentiation primary human lung fibroblasts overexpression constitutively active shp reduced responsiveness offibroblasts profibrotic stimuli including significant reductions cell survival myofibroblast differentiation shp effects mediated deactivation fibrosis relevant tyrosine kinase serine threonine kinase signaling pathways mice carrying noonan syndrome associated gain function shp mutation shp resistant bleomycin induced pulmonary fibrosis restoration shp levels vivo lentiviral delivery blunted bleomycin induced pulmonary fibrosis conclusions data suggest shp important regulator fibroblast differentiation loss observed ipf facilitates profibrotic phenotypic changes augmentation shp activity expression investigated novel therapeutic strategy ipf
background standard task pharmacogenomics research identifying genes may involved drug response variability pharmacogenes genomic experiments tended generate many false positives computational approaches based use background knowledge proposed molecular networks biomedical literature used whereas many resources available method propose consume diverse larger set resources using linked data related either genes drugs diseases one advantages linked data built standard framework facilitates joint use various sources thus facilitates considering features various origins propose selection linkage data sources relevant pharmacogenomics including example disgenet clinvar use machine learning identify prioritize pharmacogenes probably valid considering selected linked data identification relies classification gene drug pairs either pharmacogenomically associated experimented two machine learning methods random forest graph kernel results compared article results assembled set linked data relative pharmacogenomics triples coming six distinct resources learning data random forest enables identifying valid pharmacogenes measure folds cross validation whereas graph kernel achieves measure list top candidates proposed approaches provided obtention discussed
future nanoplasmonic interconnects next generation computing platforms dependent development active devices compensating high losses metallic waveguides present investigate gain characteristics electrically pumped nanoplasmonic amplifier design telecommunications wavelength finite difference time domain simulations device shown capable coupled nanoplasmonic interconnect network restoring signal amplitude hundred micrometers propagation ghz pulse repetition rates maintained without significant pulse distortion offering possibility incorporating ultrahigh bandwidth nanoplasmonic interconnects hybrid optical electrical circuits
industry impact manufacturing sector well documented however service sector understudied also facing challenges mass customization digital enhancement smart work environment efficient supply chain aim study fill research gap exploring issues industry service sector cases hospitality industry challenges industry require continuous innovation learning dependent people enterprise capabilities appropriate management approaches play vital role development dynamic capabilities effective learning innovation environment paper proposes framework management practices promote environment innovation learning organization hence facilitate business match pace industry facilitating technology acceptance digital enhancements implementation cyber physical systems cps study integrates literature logical beliefs suggest appropriate management practices industry represents one initial attempts draw research attention towards important role management practices industry recent studies restricted technological aspects semi structured interviews hospitality employees conducted explore management practices suitable meeting challenges industry specifically informing service sector
development advanced manufacturing engineering selecting supplier scientifically makes improving competitive power paper aimed suggest methodology leading effective supplier management processes utilizing information obtained supplier selection processes first evaluative indicator architecture afforded throughout normalizing value indicator processed value looked distribution random variable method confirming indicator weight based theory entropy lies information given model supplier selection build finally simulative example given illustrates method avail select supplier enhance enterprise competence
barad diffractive methodology used explore one man encounter parkinson disease long exposure pesticides home maintenance study moved realist account relevant studies toxicology entomology neurology toward onto ethico epistemological enquiry asked humans insects live work within shared mattering minerals water time constructed memories father later life explored within masculine discourses protection family invading insects intra active reconsideration contradictions involved use poison care harm new materialist theorizing took focus exploration difference experienced one fragile body toward larger engagement material discursive forces ending questions modernism tenaciousness human subjectivities time changing climate movement species around globe
enteral strictures ire frequent indication surgery crohn disease postoperative complications increased patients poor preoperative nutritional status common patient population present year old female longstanding crohn disease admitted digestive health center four weeks increasing abdominal symptoms radiographic evidence smallbowel obstruction caused ileal stricture given poor nutritional status team elected pursue metallic enteral stenting bridge surgical resection two wall stents placed luminal patency subsequently confirmed fluoroscopic study patient tolerated regular diet discharged seen follow remained asymptomatic wished defer surgical intervention indefinitely
objectives conditions adolescents access birth control debated policy makers health officials time given variability fluidity law policy area high stakes described advocates access identifying predictors electorate opinion important methods study utilized national panel data gathered examine associations adults pornography consumption attitudes toward adolescents access birth control results consistent social learning perspective media pornography consumption associated positive attitudes toward adolescents access birth control even accounting birth control attitudes multiple potential third variables consistent wright acquisition activation application model media sexual socialization association stronger morally individualistic adults contrary selective exposure perspective media birth control attitudes predict pornography consumption conclusions findings implications prediction birth control attitudes specifically socializing influence pornography generally
building information modeling bim major upheaval construction industry although bim advantages construction management proved many papers reviewed still many limitations inhibit organizations use bim models efficiently however advancement application programming interface api recent years facilitated employing bim construction industry research contributes state practice construction management developing api codes automate estimation construction developed api automatically filters items related particular discipline within particular work area facilitate systematical quantity take different work areas allows planner define proper work areas estimate required materials man hours different work areas throughout project results developed automated approach compared hand calculated results well results calculated bim software interface special cases finally research validated case study actual petrochemical project
paper devoted studying behaviour small scale wind turbine differential planetary gearbox control torque applied external ring gearbox wind receiving element rigidly joined carrier rotor electrical generator rigidly joined sun gear closed mathematical model mechanical system question constructed find effective control strategies model takes account aerodynamic load upon blades turbine well electromagnetic torque acting rotor generator operation mode mechanical system corresponds steady point model equations performed parametrical analysis dynamical system found set possible operation modes suggested different control algorithms constructed control laws allow mechanical system approach preferable operation mode initial conditions solved control problem piecewise constant control linear feedback control discussed different purposes control mechanical system question
micro particle image velocimetry micro piv quantitative full field technique velocity measurement flows microfluidics flow fields newtonian non newtonian fluids microchannels investigated micro piv velocity profiles various polymethyl methacrylate square microchannels measured polyacrylamide aqueous solutions different concentrations served non newtonian fluids two viscous newtonian fluids also employed serve reference particular validate lattice boltzmann simulation satisfactory flow measurements could realized micro piv technique experimental velocity profile compares well simulation approximate solution experimentally measured velocity profile lead quantification flow index non newtonian fluids inline rheological characterization
background hiv related stigma always major obstacles effective hiv response worldwide effect hiv related stigma hiv prevention treatment particularly serious china study examine stigma attitude towards people living hiv aids plwha among general individuals heilongjiang province northeast china factors associated stigma attitude including socio demographic factors hiv aids knowledge methods cross sectional survey carried heilongjiang province china total general individuals age years four villages rural areas two communities urban areas drawn using stratified cluster sampling standardized questionnaire interviews administered univariate multivariate log binomial regression performed assess factors affecting stigma attitude towards plwha results proportions participants holding stigma attitude towards plwha among rural respondents among urban respondents multivariate log binomial regression analysis among rural participants urban participants showed greater knowledge hiv transmission misconceptions significantly associated lower stigma attitude towards people living hiv among urban participants higher education level high school primary school less middle school primary school less also significantly associated lower stigma attitude towards plwha conclusions level stigma attitude towards plwha higher rural areas urban areas heilongjiang meanwhile individuals better aware hiv aids transmission misconceptions may hold lower stigma attitude toward plwha whether among rural urban residents
alternative splicing provides major mechanism generate protein diversity increasing evidence suggests link dysregulation splicing associated cancer genome wide alternative splicing profiling lung cancer remains largely unstudied generated alternative splicing profiles lung adenocarcinoma wad lung squamous cell carcinoma lusc patients tcga using rna seq data prognostic models splicing networks built integrated bioinformatics analysis total alternative splicing events significantly associated patient survival luad lusc respectively including egfr pikc rras mapkapi fgfr area curve receiver operator characteristic curve prognostic predictor nsclc days overall survival also luad lusc separately interestingly splicing correlation networks uncovered opposite roles splicing factors luad lusc created prognostic predictors based alternative splicing events high performances risk stratification nsclc patients uncovered interesting splicing networks luad lusc could underlying mechanisms elsevier rights reserved
previous studies reported young participants typically date events remember longer believe experienced period childhood present study investigated whether participants aged years dated events related relinquished memories period childhood younger people whether dated events period later life study also compared believed nonbelieved memories respect memory perspective person perspective results indicated majority middle aged older people dated nonbelieved memories period childhood median age years correlation found participants current age age time nonbelieved event occurred addition results showed believed memories likely retrieved person perspective nonbelieved memories elsevier inc rights reserved
purpose examine effect skin skin care ssc stress perception mothers provided ssc late preterm born infants mothers provided blanket holding design methods longitudinal group randomized controlled trial infant mother dyads recruited level neonatal intensive care unit upper midwest outcome measure maternal stress measured using parental stressor neonatal intensive care unit pss nicu scale pre post ssc intervention demographic mother infant covariates extracted medical records physiologic stability measured stability cardiorespiratory system preterm infants scrip score study personnel used daily logs track frequency duration ssc holding sessions results intervention control groups similar pre mean standard deviation ssc holding post intervention mean standard deviation ssc holding overall stress scores hours ssc holding positively correlated change stress scores entire scale infant appearance parent role alteration subscales relationship remained significant controlling infant length stay scrip score implications practice mothers provide ssc may experience stress related facilitated progression mother infant relationship implications research relationship increased stress number hours ssc holding warrants investigation
paper two approaches computation shape diameter function sdf gpu outlined compared sdf scalar function describing local thickness object used consistent mesh partitioning skeletonization first approach reorganized tracing rays well suited rasterization hardware best knowledge first method show compute sdf using rasterization hardware without need acceleration data structures second approach uses parallel ray casting octree traversal using opencl demonstrate first method achieves similar results ray casting using opencl addition faster large meshes simpler implement furthermore extend sdf computation fast post processing using texture space diffusion fast sdf computation used many applications automatic skeleton extraction demonstrate article elsevier ltd rights reserved
reinforcement used soil construction roads soft clay important determine level service road built damage defects road surface indicator level road dropped shows deformation road research analysis carried long term effect trial test road constructed batu pahat soft clay bpsc recess uthm research reinforcement using rawell geosynthetic clay liner rgcl best stability low flow stiffness modulus mpa peak load lower horizontal deformation compared woven geotextile section section without geotextile terms deformation seen clearly physical observations section without geotextile suffered significant damage others settlement road also analyzed longitudinal section plotted based result leveling work settlements visible way right side road trial lab tests conducted indicate coring samples obtained sites section meets specifications set jabatan kerja raya jkr terms stability flow stiffness study trial road built soft soil used test site uniqueness roads three different types reinforcements
substitution boxes boxes fundamental mechanisms symmetric key cryptosystems boxes guarantee cryptosystem cryptographically secure make nonlinear boxes used conventional modern cryptography mostly constructed finite galois field extensions binary field presented novel construction scheme boxes based elements subgroups multiplicative groups units commutative finite chain rings type majority logic criterion mlc applied apprehended boxes owing checked strength
electronic ionic conductivities conducting polymers change function oxidation state yet properties generally considered modeling electrochemistry electrochemically driven actuation materials effects significant particularly large ranges oxidation state long films electrical contact made one end study transmission line model implemented conductivities vary function local oxidation state variation based measured values time domain model based transmission line model implemented using state space representation voltage drop along length film away attachment point variation electronic conductivity state charge along length necessitated use nonlinear model obtain effective predictions response film dimension used general approach demonstrated may applied situation properties vary position oxidation state batteries supercapacitors last step showed successful application model predict actuation polypyrrole linear actuator
point alignment important topic computer vision order implement cross stitch embroidery automatic way grid points raster like pattern desired recognized first paper design algorithm align grid points raster like pattern case checkerboard pattern proposed method used recognize weave holes cross stitch pattern method implemented four steps first vertices boundary extracted via removing inner points next four corner points detected extracted boundary points left lower left upper points positioned finally points alignment implemented starting left lower point bottom top left right comparison experiments demonstrated method robust geometrical distortion pose change method applied align weave holes cross stitch pattern results showed proposed method addressed potential application machine weave cross stitch elsevier gmbh rights reserved
previously proposed schemes use temporary identities mobile users provide unlinkable anonymous authentication mobile users satellite network control center ncc temporary identities picked random session agreed mobile user ncc next session although schemes provide full anonymity computationally efficient common problem strategies adversary able desynchronize temporary identity shared ncc means simple jamming attack certain round authentication protocol results denial future sessions unless registers new identity ncc paper propose new authentication scheme mobile satellite networks avoid using synchronized temporary identities always vulnerable desynchronization attacks also avoid multi round authentication phase order reduce jamming effect instead mobile user able create new blinded version clear identity established session noninteractively allowing anonymously authenticate ncc fully unlinkable fashion moreover milliseconds one move non interactive way able establish session key ncc fully anonymous authenticated way new scheme uses recent advances elliptic curve cryptography hence efficient implementation mobile devices limited resources rigorous security analysis using broadly accepted burrows abadi needham logic informal security analysis simulation formal security verification using widely known automated validation internet security protocols sapplications tool show scheme secure various known attacks john wiley sons ltd
touch primary nonverbal communication channel used communicate emotions social messages despite importance channel still little explored affective computing field much focus placed visual aural channels paper investigate possibility automatically discriminate different social touch types propose five distinct feature sets describing touch behaviours captured grid pressure sensors features combined together using random forest boosting methods categorizing touch gesture type proposed methods evaluated haart gesture types different surfaces cost gesture types surface datasets made available social touch gesture challenge well chance level performances achieved accuracy haart cost testing datasets respectively
solar energy research community realized redundancy image forming collecting concentrating solar energy discovery nonimaging type radiation collection mechanism since various nonimaging concentration mechanisms proven superior collection efficiency imaging counter parts feasibility using nonimaging concentrators successfully stationary applications rekindled interest economic benefits appealing owing elimination tracking costs installation operation maintenance atixiliary energy paper exhaustive review available nonimaging concentrating mechanisms stationary applications mind paper also explores idea coupling nonimaging concentrators passive solar tracking mechanism
ultrathin highly thermally conductive heat spreader fabricated layer layer stacking hydroxylated boron nitride nanosheets hbnns first time hbnns prepared molten hydroxide assisted liquid exfoliation hexagonal boron nitride powder prepared heat spreader hbnns exhibits high thermal conductivity along plane direction enhanced annealing hydroxylation heat spreader thickness possessed excellent thermal stability negligible weight loss wide temperature range degrees resulting promising applications heat dissipation electronic components operated high working temperature
study prototype site cyclic loading experiments carried reinforced cushions constructed geoocell geotextile confirm stability reinforced ground experiment reinforced grounds methods constructed continuously site cycle loading given load vehicle ground results reinforcing effect combination geocell geotextile cushion similar combination geocell geogrid cushion
background days prior ovulation crucial emergency contraception efficacy ulipristal acetate upa levonorgestrel lng capacity inhibit follicular rupture never compared directly time cycle study design raw data three pharmacodynamics studies similar methodology pooled allow direct comparison upa lng lng meloxicam ability prevent ovulation administered orally advanced follicular phase leading follicle results forty eight lng treated cycles lng meloxicam upa cycles placebo cycles compared follicle rupture delayed least days lng lng meloxicam upa placebo treated cycles respectively upa effective lng placebo inhibiting follicular rupture lng administered time cycle different placebo addition meloxicam improved efficacy lng preventing follicular rupture lng placebo non significant upa upa effective preventing rupture days following treatment even administered time luteinizing hormone surge upa lng placebo none treatments effective administered day peak median time treatment rupture days ulipristal cycles days placebo lng lng meloxicam cycles conclusion although treatment effective inhibiting follicular rupture administered late follicular phase upa effective treatment delaying ovulation least days cycles lng different placebo inhibiting follicular rupture advanced phase cycle treatment effective postponing rupture administered day peak elsevier inc rights reserved
direct drive wave energy converter electrical generator directly coupled reciprocating motion waves resulting variable frequency variable voltage output zero power dips within wave cycle variable reluctance permanent magnet machines capable reacting large forces required direct drive wave energy converter suffer low power factor power control strategy presented optimizing die electrical power vrpm machines satisfying grid requirements constant voltage frequency power frequency tuning control wave energy devices using die electrical system demonstrated simulation test rig designed emulate wave energy converter
article study classical single item economic lot sizing problem production cost functions assumed piecewise linear lot sizing problem fundamental lot sizing research applicable wide range production planning models intractability problem related value number different breakpoints production cost functions arbitrary problem known hard florian lenstra rinnooy kan however fixed solved polynomial time koca yaman alcturk far efficient algorithm solve problem complexity number periods planning horizon koca article present improved exact algorithm solving problem complexity reduced center dot log also improves upon computational efficiency solving existing lot sizing problems important special cases model order achieve efficient implementation algorithm makes use specific data structure named range minimum query rmq elsevier rights reserved
children make many decisions whether disclose performance peers teachers parents others previous research found children disclosure declines age older children teenagers preferentially choose peer audience performance disclosure based similar achievement research examines younger children choice disclosure audience whether young children predict people distinguish peers different achievement levels whether younger children expect preferential selections peers performance disclosure one hundred thirty nine children aged years asked character disclosure classroom performance information least age years children predicted significantly greater disclosure failure high achieving peer successful asked predict disclosure success however children age groups discriminate disclosing high achieving low achieving peer evidence suggests young children may show valence matching preferences older children early school ages critical time children begin adopt social norms around disclosure impinge possible help seeking copyright john wiley sons ltd
using genetic mouse model faithfully recapitulates disc genetic alteration strongly associated schizophrenia psychiatric disorders examined impact mutation within prefrontal cortex although cortical layering cytoarchitecture proteome found largely unaffected electrophysiological examination mpfc revealed neuronal hyperexcitability alterations short term synaptic plasticity consistent enhanced neurotransmitter release increased excitability layer iii pyramidal neurons accompanied consistent reductions voltage activated potassium currents near action potential threshold well enhanced recruitment inputs arising superficial layers layer observed reductions paired pulse ratios enhanced short term depression layer synapses arising superficial layers consistent enhanced neurotransmitter release synapses recordings layer iii pyramidal neurons revealed action potential widening could account enhanced neurotransmitter release significantly found reduced functional expression voltagedependent potassium channel subunit substantially contributes excitability short term plasticity alterations observed underlying dysregulation expression attributable camp elevations pfc secondary reduced phosphodiesterase activity present disc deficiency rescued pharmacological blockade adenylate cyclase results demonstrate potentially devastating impact disc deficiency neural circuit function partly due dysregulation leads dual dysfunction consisting enhanced neuronal excitability altered short term synaptic plasticity
determined retinoids liver content male female mice fetuses study possible sex difference prenatal development ascertain vitamin metabolism similar sexes study performed developmental days fetuses collected two main groups control manipulation vitamin administration vitamin developmental day group subdivided sex retinoids analyzed high performance liquid chromatography hplc control group retinol liver sexes fetuses vitamin group began accumulate retinol day sexual dimorphism exhibited retinyl palmitate content control group showed sexual dimorphism developmental days vitamin group differences significant conclusion study showed sexual dimorphism retinoids liver content mice development evidences sex difference vitamin metabolism different capacities store metabolize retinoids
schizophrenia considered disorder abnormal brain connectivity although whole brain maps averaged bivariate voxel correlations successfully applied study connectivity abnormalities schizophrenia maps adequately explore multivariate nature brain connectivity adapt novel method high dimensional regression supervised principal component regression estimate brain maps multivariate non redundant connectivity nrc resting functional magnetic resonance imaging fmri data patients schizophrenia matched controls disorder related differences nrc involved caudate hyper connectivity hypo connectivity several cortical areas dorsal cingulate cuneus right postcentral cortex abnormalities coupled abnormalities amplitude signal fluctuations minor extent differences dimensionality connectivity patterns quantified number supervised principal components second level seed correlation analyses linked observed abnormalities additional set brain regions relevant schizophrenia thalamus temporal cortex non redundant connectivity maps proposed new tool complement information provided already available voxel based whole brain connectivity measures
primary objective study examine disparities childcare infant feeding practices family structure single mother two parent households whether household income level may modify observed associations family structure cross sectional data analysis conducted using nationally representative sample children aged years enrolled national survey children health analytic sample children single mothers children two parents children single mothers used non parental childcare adjusted odds ratios aor confidence intervals especially relative care centre care children two parents lower rates breastfeeding months aor ever breastfed aor reported among children single mothers two parents many observed differences childcare arrangements breastfeeding family structure remained significant low high income households however children low income single mothers last minute changes childcare arrangement aor children low income two parent households children high income single mothers early introduction complementary foods aor children high income two parent households study documented disparities childcare arrangements infant feeding practices family structure regardless income level findings support need comprehensive policies address maternal employment leave childcare support workplace accommodations support breastfeeding children years especially among single mothers regardless income
work presents application power series method psm find solutions partial differential algebraic equations pdaes two systems index one index three solved show psm provide analytical solutions pdaes convergent series form present post treatment power series solutions laplace pade resummation method useful strategy find exact solutions main advantage proposed methodology procedure based straightforward steps generate secular terms depends perturbation parameter
health benefits hop polyphenols well studied present investigation examined antioxidant activity anti nitric oxide production anti adipocyte differentiation polyphenols extracted hops hpp harvested different times years saaz hop variety czech republic used vitro assays twenty three polyphenols quantitatively analyzed using orbitrap liquid chromatography mass spectrometry health promoting effects assayed individually strong effects low concentrations hpp observed three assays significant increase anti adipocyte differentiation activity per unit weight hpp obtained early harvested samples significant difference anti production activity per unit weight hpp observed among different harvest years hpp significantly increased early harvested samples results suggest vitro functional properties hops vary harvest time year dependent different polyphenols elsevier ltd rights reserved
use drugs intrinsic anticholinergic properties widespread among old age persons growing body evidences suggest high anticholinergic burden associated physical cognitive impairment however association anticholinergic drug use functional status still poorly investigated particularly among subjects initial cognitive impairment cross sectional study examining association drug related anticholinergic burden functional status cognitively healthy mild cognitive impairment mci mild alzheimer diseases subjects data gathered regal project rete geriatrica alzheimer geriatric network alzheimer disease large longitudinal italian multicentric clinical based study promoted italian society gerontology geriatrics sigg outpatients older years admitted memory clinics total sample size estimated according global effect size type error power subjects functional status evaluated katz index independence activities daily living adl lawton brody instrumental activities daily living iadl scales drug related anticholinergic burden estimated anticholinergic risk scale ars total population used least one drug anticholinergic properties drug use associated partially dependence adl independently gender number drugs comorbidity index presence clinically relevant neuropsychiatric symptoms adjusted mmse anticholinergic drug use associated ability iadl task male mci subjects significant impairment shopping drug management use medications anticholinergic properties common among older persons cognitively health well cognitive impairment results suggest use anticholinergic drugs associated functional impairment especially old age subjects initial cognitive impairment minimizing anticholinergic burden result maintaining daily functioning especially vulnerable population mci mild
cancer transcriptome analysis one leading areas big data science biomarker pharmaceutical discovery forget personalized medicine yet cancer transcriptomics postgenomic medicine require innovation bioinformatics well comparison performance available algorithms data analytics context value network generation algorithms widely underscored addressing salient questions cancer pathogenesis analysis cancer trancriptome often results complicated networks identification network modularity remains critical example delineating druggable molecular targets network clustering useful depends network topology notably performance different network generating tools network cluster identification little investigated date hence using gastric cancer transcriptomic datasets compared two algorithms generating pathway versus gene regulatory network based ncs showing pathway based approach better agrees reference set cancer functional contexts finally applying pathway based identification transcriptome datasets describe cancer ncs associate candidate therapeutic targets biomarkers observations collectively inform future research cancer transcriptomics drug discovery rational development new analysis tools optimal harnessing omics data
purpose nonmedical pocket cost patients companions office visits routine glaucoma care extensively studied united states evaluate potential key predictors patient expenditures critical assessing cost effectiveness glaucoma health care delivery materials methods total patients responded survey clinics clinical practice settings main outcome measures included average visit yearly expenditures results patients majority female african american median age years median range mean expenditure per patient visit patients companions paid average visit expenditure average visit expenditure retired patients less compared nonretired patients patients living rural suburban area paid per visit respectively compared patients living urban area patients noncommercial insurance paid less average visit expenditure median yearly patient expenditure patients companions paid yearly expenditure without companions whereas retired patients paid less yearly expenditure nonretirees patients noncommercial insurance paid less yearly expenditure conclusions although small part total cost glaucoma care nonmedical pocket costs constitute substantial noncovered medical expense patients united states patients employed come companions live nonurban areas medicare greater expenditures
background fundamental motor skill proficiency essential engagement sports physical play development healthy lifestyle children motor delays without disabilities lack motor skills necessary participate games physical activity tend spend time onlookers peers intervention programs crucial promoting motor skill development children motor delays mastery climate interventions shown positively impact children motor performance unknown impact cognitive strategies used children within climates furthermore although vigorous play seems related development gross motor skills still unknown children without disabilities would benefit exercise play interventions purpose study examined effects interventions motor skill development verbal recall children motor delays sample included children without disabilities research designs one hundred thirty eight children urban public schools referred present study children assessed using test gross motor development second edition tgmd checklist sixty four children disabilities without met inclusion criteria score less fifth percentile tgmd participants randomly assigned week interventions emphasizing gross motor skill practice data collection analysis children assessed pre post intervention groups disability time analyses variance repeated measures last factor conducted change scores test comparisons delta scores cohen also calculated results group demonstrated significant positive changes intervention period group showed superior locomotor object control performance higher recall verbal cues post intervention compared group children without disabilities within showed similar patterns improvement intervention demonstrate significant improvements conclusion children without disabilities showed improvements motor skills exposed incorporating six target structures structures included providing feedback encouragement providing opportunities decision making establishing personal goals including parents recognition children achievements creating opportunities experience leadership self pacing guiding children use verbal cues modeling practicing gross motor skills providing demonstrations teaching children self monitor performance instruction therefore seen critical learning gross motor skills demonstrated findings although opportunities vigorous play within intervention children show improvements motor performance findings suggest new trends teacher education physical education prioritize physical activity good motor skill instruction may advantageous children early years reconsidered
introduction increasing popularity trekking alpine regions drawn attention high altitude associated health concerns case report report case cerebral venous infarction consequence hypercoagulable state induced secondary polycythemia adaptation high altitude conclusions patients present focal neurological symptoms hemiparesis addition symptoms acute mountain sickness high altitude cerebral edema headache nausea vomiting dizziness cerebral venous infarction considered
satellite radio beacons used june probe ionosphere modified radio beam produced eiscat high power high frequency transmitter located near tromso norway amplitude scintillations variations phase mhz signals russian navigational satellites passing modified region observed three receiver sites several papers stressed polar ionosphere thermal self focusing striations ionospheric modification main mechanism resulting formation largescale hundreds meters kilometers nonlinear structures aligned along geomagnetic field magnetic zenith effect also claimed maximum effects caused small scale tens meters irregularities detected satellite signals also observed direction parallel magnetic field contrary studies present paper shows maximum amplitude scintillations correspond strictly magnetic zenith direction high latitude drifts typically cause considerable anisotropy small scale irregularities plane perpendicular geornagnetic field resulting deviation amplitude scintillation peak relative minimum angle line sight satellite direction geomagnetic field lines variance logarithmic relative amplitude fluctuations considered useful quantity studies experimental values variance compared model calculations good agreement found also shown experimental data satellite passes variance maximum occurs minimum phase fluctuations indicating artificial excitation large scale irregularities minimum excitation small scale irregularities maximum
cigarette smoking often associated development several respiratory diseases however diagnosed early changes lung tissue caused smoking may reversible computerised respiratory sounds shown sensitive detect changes within lung tissue measure however unknown able detect changes lungs healthy smokers study investigated differences computerised respiratory sounds healthy smokers non smokers healthy smokers non smokers recruited university campus respiratory sounds recorded simultaneously chest locations right left anterior lateral posterior using air coupled electret microphones airflow recorded pneumotachograph breathing phases detected using airflow signals respiratory sounds validated algorithms forty four participants enrolled smokers mean age years mean fev predicted non smokers mean age years mean fev predicted smokers presented significantly higher frequency maximum sound intensity inspiration lower expiratory sound intensities maximum intensity mean intensity higher number inspiratory crackles median interquartile range non smokers significant differences computerised respiratory sounds smokers non smokers found changes respiratory sounds often earliest sign disease thus computerised respiratory sounds might promising measure early detect smoking related respiratory diseases
first geosynthetic retaining wall brazil constructed instrumented high geotextile reinforced soil wall poorly draining backfill structure showing excellent performance throughout service life even long periods rainfall past excellent performance wall attributed influence soil confinement geotextile strength properties well comparatively high interface shear strength fine soil nonwoven geotextile also evidence beneficial effect internal drainage capacity using nonwoven geotextiles reinforcements order clarify understanding performance pioneer history case wall wall effect nonwoven geotextiles reinforcements fine grained soils full scale laboratory models geotextile reinforced walls tested wetting conditions results instrumentation shown significant positive water pressures relatively small displacements even intense periods precipitation consistency field laboratory investigations provides strong evidence support use nonwoven geotextiles reinforce poorly draining soils
purpose evaluate effect bariatric arterial embolization bae non spherical polyvinyl alcohol pva particles systemic ghrelin levels weight change gastric ulceration risk swine model materials methods march february ten healthy swine used study mean weight range animals randomly assigned two groups embolized group bae performed control group embolized group bae performed selectively infusing pva gastric arteries supplied fundus stomach control group sham procedure performed saline infusion plasma ghrelin levels prospectively obtained baseline every weeks thereafter endoscopy performed weeks bae see whether gastric ulcer occurred determine durability occluded arteries repeated celiac trunk angiography performed weeks bae swine killed necropsies performed results mean post procedure ghrelin value decreased embolized group week mean week mean relative baseline respectively ghrelin levels significantly decreased embolized control groups significant body weight change follows baseline endpoint control embolized groups respectively however difference groups significant endpoint embolized group ulcerations identified three animals recanalization embolized arteries noted follow angiography three animals respectively conclusion bae pva particles transiently suppress ghrelin levels embolized animals levels significantly different compared controls stomach ulcerations identified embolized animals
background aim introduction sofosbuvir revolutionized treatment chronic hepatitis study planned observe whether efficacy tolerability sofosbuvir based regimens demonstrated phase clinical trial results translate real life clinical practice methods prospective non randomized observational study conducted dayanand medical college hospital punjab included consecutive treatment naive patients chronic hepatitis genotypes treated sofosbuvir based regimens response therapy assessed week rapid virological response week end treatment response weeks cessation therapy sustained virological response svr results patients diagnosed chronic hepatitis virus considered treatment direct acting antivirals patients opted treatment age years men genotype genotype genotype viral load high patients cirrhosis decompensated patients genotypes treated triple drug regime pegylated interferon ribavirin sofosbuvir weeks patients genotype treated either dual therapy sofosbuvir ribavirin weeks triple therapy weeks svr achieved svr rates differ among different genotypes higher non cirrhotics conclusion sofosbuvir based treatment regimens achieve high svr rates real life cohort indian patients chronic hepatitis infection including cirrhosis
depression associated decreased engagement behavioural activities wide range activities promoted simulating via mental imagery mental imagery positive events could thus provide route increasing adaptive behaviour depression current study tested whether repeated engagement positive mental imagery led increases behavioural activation participants depression using data randomized controlled trial blackwell clin psychol sci doi participants randomized week positive imagery intervention active non imagery control condition completed via internet behavioural activation assessed five times months follow using behavioural activation depression scale bads bads scores increased time groups initial greater increase imagery condition investigating mental imagery simulation positive activities means promote behavioural activation depression could provide fruitful line enquiry future research
current controller fast transient response satisfactory steady state characteristics required pmsm servo system paper application active disturbance rejection control adrc current loop proposed design proceeding first order adrc controller current loop elaborated taking use adrc controller analysis digital control delay effect improved method focusing delay effects presented taking measures current regulation achieve high performance simulation experimental results verify correctness feasibility proposed method
previous research investigated deleterious effects child maltreatment child development however little research examined development children live caregivers risk maltreatment child development outcomes study utilized self report data caregivers included child abuse potential inventory capi parenting stress inventory short form psi adaptive behavior assessment system edition abas children ages rural appalachian community caregivers lower child abuse potential children used fewer school services older children caregivers lower household income better total adaptive skills caregivers lower child abuse potential children used fewer school services older children better functioning academic skills subscale children used fewer school services older lower family income greater self care skills finally children used fewer school services greater communication skills parent child dysfunction related child development outcomes findings demonstrate educators unique position intervene support children risk maltreatment
paper proposed energy efficient adder employing multistage latency approximate computing technology delay adder decreases critical path adder divided multiple short stages series predictors approximate computing technology exploited make tradeoff output quality energy efficiency proposed design applied discrete cosine transformation dct image processing support vector machine svm algorithm machine learning verify availability simulation results demonstrate proposed approximate adder provides power delay product pdp reduction orders magnitude reduction output error recent counterpart designs compared conventional accurate ripple carry adder rca kogge stone adde ksa proposed design presents pdp reduction cost negligible output quality reduction qualified peak signal noise ratio psnr dct decreases classification accuracy svm decreases
type cyclic nucleotide phosphodiesterases pde major members superfamily enzymes pde involved modulation intracellular signaling mediated camp broadly expressed human tissues present large amounts liver pdes last decade key therapeutic targets several inflammatory diseases recently significant body work underscored involvement different kinds cancer attention paid liver cancer present study investigated effects two pde inhibitors rolipram growth human hepatoma hepg cells treatment inhibitors caused marked increase intracellular camp level dose time dependent effect cell growth concentrations inhibitors halved cell proliferation used cell cycle experiments rolipram produced decrease cyclin expression particular cyclin well increase evaluated western blot analysis changes intracellular localization cyclin also observed treatments addition inhibitors caused apoptosis demonstrated annexin cytofluorimetric assay analysis caspase activity results demonstrated treatment pde inhibitors affected hepg cell cycle survival suggesting might useful potential adjuvant chemotherapeutic chemopreventive agents hepatocellular carcinoma wiley periodicals inc
background three competing theories mechanism mitral coaptation normal subjects evaluated color doppler vector flow mapping vfm beginning ventricular ejection breaking jet diastolic inflow returning diastolic vortices impacting leaflets surfaces methods results analyzed color doppler frames vfm measurements normal subjects coaptation occurred ejection onset color doppler frames larger anterior smaller posterior vortices circle back cases strike ventricular surfaces leaflets first closing begins frame first time vortex velocity normal ventricular surface anterior leaflet aml greater mitral orifice angle attack vortical flow onto aml twice high angle flow onto valve orifice thus moment coaptation begins vortical flow strikes mitral leaflet higher velocity higher angle attack orifice flow thus greater force according breaking jet theory one would expect see novo flow perpendicular leaflets beginning transmitral flow terminates instead returning continuous vortical flow impacts valve builds continuously wave conclusions late diastolic vortices strike ventricular surfaces mitral leaflets contribute valve coaptation permitted concomitant decline transmitral flow
nanowire perovskite chnhpbi successfully grown cheap commercial pet substrate modified two step spin coating procedure chnhi solution small amount dmf used found morphology crystallization behavior nanowire perovskites depended strongly amount dmf interfaced zno thin films nanowire perovskites showed faster extraction electron usual thin film perovskites possibly due larger surface volume ratio better contact zno specific charge injection rate high achieved could potential enhance performance flexible perovskite solar cell elsevier rights reserved
perfect metamaterial absorber realized properties theoretically numerically experimentally investigated microwave frequencies addition polarization incident angle independencies also tested structure theoretical numerical experimental results show proposed model many advantages compared literature perfect absorption polarization incident angle independencies simple design operation sufficiently wide band simple configuration chosen proposed model easily tuned frequency regimes realize new absorbers applications sensors stealth technology
aircraft electric network complex system consisting many different elements integrated form unique entity designed perform well defined mission current state network conceptual design based standards defined aircraft manufacturer consequence electric subsystem suppliers local optimizations fulfill standards separated way mechanistic approach results set optimized subsystems necessarily optimal respect network level overcome problem present design approach called epfm extended pareto front method based separated subsystem optimizations aims finding optimal configuration electrical network system level epfm discussed regard computational cost collaboration requirements aeronautical industrial context compared classical mechanistic approach
background use internet seekers health related information provides convenience accessibility diverse sources variable quality many medical conditions suggestion patients may find empowerment engaging internet health care strategies communities profile consumers online health information knee pain explored objective objective identify characteristics motivations online health information seekers accessing online health community kneeguru study designed obtain respondents sociodemographic profile together main reasons motivations joining community health information seeking behavior extent knee problems general internet usage methods undertook online questionnaire survey offered users website june july mix open closed questions used facilitate inductive enquiry quantitative responses analyzed using univariate analysis qualitative thematic analysis open responses completed conceptual model developed results one hundred fifty two respondents took part response rate mean age years cohort female domestic partnerships employed higher education qualifications white caucasian ethnicity females associated joining order get emotional support users respondents self perception health associated reported quality life facebook users associated joining share experiences post surgery respondents associated joining compare symptoms users three key themes induced condition emotion support respondents expressed distress frustration uncertainty prognosis around various knee conditions users preferring initially observe rather engage conversely strong desire inform support community members stated reciprocation ideas experiences conceptualized filter takes individual condition emotional response condition basis support filter facilitated validation outcome engagement conclusions study line wider literature suggests users online knee specific community typically female middle aged white caucasian married employed attained level higher education users demonstrate pragmatic approach health care information altruistic motivations desire share experiences means validation finding emphasizes means promoting efficient appropriate online health care demonstrates benefits internet viable complement clinical engagement
thermistor widely used sensor temperature measurement due high sensitivity fast response non linearity thermistor gives rise several difficulties chip interface direct digital readout wireless transmission hence effective lineariser needed overcome difficulties study artificial neural network based lineariser developed thermistor connected operational amplifier circuit operational amplifier based thermistor signal conditioning circuit exhibits stable temperature voltage relation range degrees low linearity multilayer perceptron feed forward neural network used non linearity compensation thermistor circuit improve linearity linearity achieved degrees high temperature stability notable feature proposed method non linearity error remains low entire dynamic range thermistor efficacy method established simulation studies practicality demonstrated experimental results obtained prototype unit built tested
burgers huxley equations reduced form vital importance modeling interaction reaction mechanisms convection effects diffusion transports paper applied reduced form differential transform method reduced dtm present previous works abazari borhanifar comput math appl borhanifar abazari appl math comput borhanifar abazari opt commun abazari ganji int comput math abazari abazari commun nonlinear sci numer simul solving burgers huxley equations three reduced equations namely burgers equation huxley equation burgers fisher equation results obtained employing rdtm compared previous semi analytical methods hpm appl math comput ham liao beyond perturbation introduction homotopy analysis method chapman hall crc press boca raton dtm zhou differential transformation application electrical circuits huazhong university press wuhan exact solution important result depicted rdtm results accurate comparison obtained classic hpm ham dtm numerical results reveal rdtm effective convenient quite accurate time dependance kind nonlinear equations predicted rdtm found widely applicable engineering
multi rigid body model contains structure system transmission system bridge crane gearbox established internal excitations time varying mesh stiffness tooth backlash bearing stiffness damping external torque excitation caused electric motor calculate dynamic mesh force gears reaction force bears calculate modes flexibility gearbox afterward vibro acoustic coupling model gear system built taking frequency histories bearing reaction force boundary conditions surface sound pressure radiation noise outer sound field calculated results show peaks dynamic mesh force reaction forces bearings dynamic responses gearbox appear position frequency shaft orders mesh orders harmonic frequency maximum radiated noise appear surface sound pressure outer sound field
link gain directly modulated microwave photonic link based transistor laser derived making use signal flow graph techniques contrast conventional laser diodes three terminal introduces extra microwave port impedance tuning link parameters gain contour simulations using small signal equivalent circuit model indicate potential increased link gain compared links terminated omega ports
please cite paper bustamante danileviciute espinosa gonzalez subirana cordier chevrier chatzi grazuleviciene sunyer ibarluzea ballester villanueva nieuwenhuijsen estivill kogevinas influence fetal glutathione transferase copy number variants adverse reproductive outcomes bjog nested casecontrol association study designed investigate influence maternal fetal copy number variants cnvs reproductive outcomes genotypes ten cnvs encompassing gst cyp genes assessed significant associations found child cnv genotypes particular child gstm insertion allele associated prematurity protection odds ratio whereas child gsttb insertion allele associated increased risk small gestational age odds ratio study highlights role fetal genome prenatal development also need analyse cnvs systematic manner
nowadays thermoelectric materials gained considerable attention due unique ability directly convert waste heat electricity vice versa long time researchers mainly focused developing high performance inorganic materials based alloys etc however inorganic materials various disadvantages high cost heavy metal contamination well relatively poor processability etc compared inorganic materials poly ethylenedioxythiophene pedot great potential used materials due low thermal conductivity low cost low density etc therefore attention focused preparation properties pedot pedot based nanocomposites especially one dimensional pedot pedot based nanocomposites due nanostructures always enhanced properties article presents overview synthesis pedot nanoparticles pedot nanostructures corresponding nanocomposites well properties elsevier rights reserved
immerse world becomes mobile every day ubiquitous connectivity increasing demand mobile services current mobile terminals support several access technologies enabling users gain connectivity plethora scenarios favoring mobility however management network connectivity using multiple interfaces still starting deployed lack smart connectivity management multi interface devices forces applications explicitly aware variations connectivity state changes active interface simultaneous access several interfaces etc paper analyze present state connection management handover capabilities three major mobile operating systems oses android ios windows aim conduct thorough experimental study connectivity management operating system including several versions different mobile terminals analyzing differences similarities moreover order assess mobility handled affect final user perform exhaustive experimental analysis application behavior intra inter technology handover based experience identify open issues smartphone connectivity management policies implementations highlighting easy deploy yet unimplemented improvements well potential integration mobility protocols elsevier rights reserved
aims objectivesto examine disease related stress coping strategies need information support patients inflammatory bowel disease ulcerative colitis crohn disease backgroundpsychological stress important factor ulcerative colitis crohn disease therefore coping strategies support needs considered routine clinical practice designthis qualitative study using descriptive interview based approach methodfifteen patients ulcerative colitis crohn disease interviewed interviews analysed content analysis resultsthe informants largely focused disease related stress access toilet symptoms worries relations people various reactions others social situations behavioural strategies taking actions need making plans prepare adapt social strategies seeking help information sharing feelings disease others emotional strategies distraction positive attitude acceptance adopted cope stress associated disease need information support concerned instrumental support disease related information emotional support talk disease management conclusionfaecal urgency fear losing bowel control important stressors patients inflammatory bowel disease patients handle problem using various coping strategies depending type stressful events instrumental emotional support requested primarily occurred time diagnosis disease flare ups relevance clinical practicepatients ulcerative colitis crohn disease ask information psychosocial support tailored individual needs different stages disease trajectory improve everyday life strengthen self management strategies
source apportionment river water pollution critical water resource management aquatic conservation comprehensive application various gis based multivariate statistical methods performed analyze datasets water quality liao river system china cluster analysis classified months year three groups may october february april november january sampling sites three groups groups based similarities water quality characteristics discriminant analysis determined temperature dissolved oxygen chemical oxygen demand codmn day biochemical oxygen demand bod total phosphorus volatile phenols significant variables affecting temporal variations correct assignments principal component analysis pca positive matrix factorization pmf identified eight potential pollution factors part data structure explaining total variance oxygen consuming organics cropland woodland runoff main latent pollution factor group group main pollutants oxygen consuming organics oil nutrients fecal matter group evaluated pollutants primarily included oxygen consuming organics oil toxic organics
objectives present study gather data prenatal development turkish cats angora van cats examine effects breed prenatal development three angora four van cats ranging age years used present study depending stage pregnancy gestational sac diameter gsd fetal heart diameter fhrtd fetal abdominal diameter fad fetal head diameter fhd fetal gastric diameter fgd fetal width fore fwfp rear footpads fwrp measured freezing images fetus fetal structure screen mean fhrtd value angora cats significantly greater corresponding value van cats third week gestation van cats significantly greater mean value fhd angora cats fifth week gestation significant breed differences fetal measurements result prenatal development angora van cats found similar findings present study may also used aid estimate gestational age domestic cats
impaired cognitive empathy core social cognitive deficit schizophrenia associated negative symptoms social functioning cognitive empathy negative symptoms also linked medial prefrontal temporal brain networks shared behavioral neural underpinnings suspected cognitive empathy negative symptoms research needed test hypotheses two studies evaluated whether resting state functional connectivity data driven networks components referred inter component connectivity predicted cognitive empathy experiential expressive negative symptoms schizophrenia subjects study examined associations cognitive empathy medial prefrontal temporal inter component connectivity rest using group matched schizophrenia control sample assessed whether inter component connectivity metrics associated cognitive empathy also related negative symptoms study sought replicate connectivity symptom associations observed study using independent schizophrenia sample study results revealed groups differ average inter component connectivity medial fronto temporal metric orbito fronto temporal metric related cognitive empathy moreover medial fronto temporal metric associated experiential negative symptoms schizophrenia samples findings support recent models link social cognition negative symptoms schizophrenia wiley periodicals inc
learning programming inherently exploratory activity supporting process trivial task requires resources paper proposes utilisation intelligent exploratory learning environment enhance teaching learning context minimal cost
wind power integration existing power system needs attention due uncertain nature difference creates actual forecasted wind speeds power delivery contract signed generation companies gencos distribution companies discos per forecasted speed gencos may awarded penalized independent system operator iso surplus deficit power supply paper proposes approach assess uncertainties wind speed wind integrated electrical system within completely deregulated environment work twelve spots india chosen randomly application proposed approach verify outcome proposed approach real time data actual wind speed aws forecasted wind speed fws selected spots also considered imbalance cost due mismatch forecasted actual wind speeds evaluating formulation surplus charge rate deficit charge rate modified ieee bus modified ieee bus systems considered analyzing effectiveness proposed approach elsevier ltd rights reserved
brazil cadastro ambiental rural car currently implemented policy aims geo reference properties promote monitoring compliance natural vegetation conservation requirements scholarly efforts policy attention far concentrated possible environmental impacts hereof attention devoted car might affect farmers livelihoods limited paper evaluate potential livelihood impacts car programs facilitate car registration developing conceptual framework using evidence semi structured interviews key stakeholders including farmers governments funding agencies find car programs facilitating car explicit livelihood impact goals nonetheless affect livelihoods positively negatively depending initial amount natural vegetation farmers properties farmers access credit infrastructure changing market conditions argue environmental interventions policies need consider potential livelihood impacts especially policy intervention area high poverty rates authors published elsevier open access article license
background despite proven safety efficacy rates minimally invasive approaches colon cancer remain low usa given known benefits investigating root causes underutilization methods increase laparoscopy warranted goal develop predictive model factors impacting use laparoscopic surgery colon cancer methods premier hospital database reviewed elective colorectal resections colon cancer patients identified icd diagnosis code stratified open laparoscopic approaches icd procedure codes adjusted multivariate logistic regression model identified variables predictive use laparoscopy colon cancer results total patients included laparoscopic open general surgeons performed majority procedures open laparoscopic overall use laparoscopy increased study period patients private insurance likely laparoscopy compared medicare patients adjusted odds ratio higher volume surgeons larger hospitals bed size likely approach colon cancer laparoscopically colorectal surgeons likely approach case laparoscopically general surgeons teaching hospitals hospitals midwest hospitals less beds less likely use laparoscopy conclusions patient provider hospital characteristics identified preoperatively predict undergo surgery colon cancer using laparoscopy however additional patients may eligible laparoscopy based patient level characteristics results implications regionalization increasing teaching mis recognizing addressing variables training recruiting could increase use minimally invasive approaches associated clinical financial benefits
alteration gene expression along pain signaling pathway key mechanism contributing genesis neuropathic pain accumulating studies shown epigenetic regulation plays crucial role nociceptive process spinal dorsal horn present study investigated role enhancer zeste homolog ezh subunit polycomb repressive complex spinal dorsal horn genesis neuropathic pain rats induced partial sciatic nerve ligation ezh histone methyltransferase catalyzes methylation histone resulting gene silencing found levels ezh tri methylated hktm spinal dorsal horn increased rats neuropathic pain day day post nerve injuries ezh predominantly expressed neurons spinal dorsal horn normal conditions number neurons ezh expression increased nerve injury strikingly nerve injury drastically increased number microglia ezh expression sevenfold intrathecal injection ezh inhibitor attenuated development maintenance mechanical thermal hyperalgesia rats nerve injury analgesic effects concurrently associated reduced levels ezh hktm lba gfap tnf alpha beta mcp spinal dorsal horn rats nerve injury results highly suggest targeting ezh signaling pathway could effective approach management neuropathic pain ibro published elsevier ltd rights reserved
background population based information cancer incidence prevalence outcome required inform clinical practice research contemporary data lacking many myeloid malignancy subtypes methods set within socio demographically representative population similar million myeloid malignancy data diagnoses established patient cohort information incidence survival relative overall transformation progression prevalence presented subtypes results median diagnostic age years interquartile range considerable subtype heterogeneity particularly among acute myeloid leukaemias aml medians ranged iqr aml iqr aml recurrent genetic changes five year relative survival estimates varied hugely indolent treatable conditions like chronic myeloid leukaemia couple notable exceptions males experienced higher rates worse survival females age standardized incidence rates several conditions higher males females year subtypes combined males females respectively follow potential minimum years maximum years myelodysplastic syndrome mds progression aml ranged refractory anaemia excess blasts refractory anaemia ring sideroblasts median interval mds aml diagnosis months iqr months conclusions marked incidence outcome variations seen subtype sex age confirm requirement real world longitudinal data inform aetiological hypotheses healthcare planning future monitoring therapeutic change several challenges routine cancer registration identified including need link effectively diagnostic clinical data sources review policies recording progressions transformations authors published elsevier ltd
paper three metaheuristics used solve smart grid multi objective energy management problem conflictive design maximize profits minimize carbon dioxide emissions results compared metaheuristics implemented weighted particle swarm optimization pso multi objective particle swarm optimization mopso non dominated sorting genetic algorithm nsga performance methods use multi dimensional signaling also compared technique previously shown boost metaheuristics performance single objective problems hence multi dimensional signaling adapted implemented proposed multi objective problem addition parallel computing used mitigate methods computational execution time validate proposed techniques realistic case study chosen area northern region portugal considered namely part vila real distribution grid bus assumed grid managed energy aggregator entity reasonable amount electric vehicles evs several distributed generation customers demand response contracts energy storage systems ess considered case study characteristics took account several reported research works projections findings strongly suggest signaling method clearly improves results pareto front region quality
paper presents stability analysis distributed power systems multiple converter controlled loads load converters tightly controlled behaving constant power loads low damped filters dynamic behavior system high frequency range often studied classical tools based conventional averaging techniques however power systems reduced size filter consequently high resonant frequency widely used transportation applications paper stability analysis system established based discrete time model system taking account switching frequency intrinsic nonlinearities system model impacts filter parameters interactions among constant power loads investigated proposed discrete time method moreover active stabilizer developed included dynamic model system order extend stability margin theoretical observations validated experimentally laboratory hardware prototype
sleep disorders among common clinical problems possess significant concern geriatric population importantly around elderly adults sleep related complaints sleep disorders frequently associated morbidities including age related neurodegenerative diseases mild cognitive impairment recently increasing evidence indicated disturbed sleep may serve consequence brain atrophy also contribute pathogenesis dementia therefore significantly increase dementia risk since current therapeutic interventions lack efficacies prevent delay reverse pathological progress dementia better understanding underlying mechanisms sleep disorders interact pathogenesis dementia provide possible targets prevention treatment dementia review briefly describe physiological roles sleep learning memory specifically update recent research evidence demonstrating association sleep disorders dementia plausible mechanisms discussed moreover also evaluate possibility sleep therapy potential intervention dementia
substance abuse mental health services administration samhsa created national grant program project launch linking actions unmet needs children health improve behavioral health developmental outcomes young children incorporation prevention wellness promotion practices key early childhood settings project launch supports states tribal nations territories improve coordination across early childhood systems implement core strategies prevention promotion article focuses lessons learned core strategies integration behavioral health primary care young children paper analyzes experiences sample project launch grantees describing common elements integration approaches exploring challenges promoting health preventing social emotional behavioral problems population level
gas liquid two phase flows widely encountered industry design parameters include two phase pressure drop mixing axial mixing phases effective interfacial area heat mass transfer coefficients currently high degree empiricism design process reactors owing complexity coupled flow reaction mechanism hence focus synthesizing recent advances computational experimental techniques enable future designs reactors rational manner exploring large design space high fidelity models computational fluid dynamics validated high fidelity measurements hot film anemometry hfa laser doppler anemometry lda particle image velocimetry ply etc provide high degree rigor understanding spatial distributions dispersed phases interaction scale key challenges traditionally addressed pilot scale experiments addressed advanced modelling practically complete knowledge fluid mechanical parameters desirable implement direct numerical simulations dns however current computational power permit full dns real bubble columns therefore using simplified turbulence models large eddy simulation reynolds stress epsilon etc need knowledge turbulence parameters estimation parameters currently semi empirical procedures used pending knowledge turbulence formulation governing equations cfd models except dns knowledge interface forces drag lift virtual mass basset etc needed estimations empirical correlations employed pending knowledge fluid mechanics turbulent conditions bubble columns gas liquid dispersions gas sparged form bubbles bubble rise mechanism wake detachment creates turbulence called wake generated turbulence addition energy gets transferred gas phase liquid phase quantitative amounts negligible bubble motion hindered gas liquid dispersion homogenous amounts increase increase extent hindrance however homogenous regime even extreme conditions extent energy transfer bulk gas liquid dispersions volume wake volume fairly limited contrast heterogeneous regime rates energy transfer become sizeable energy received liquid regimes also creates turbulent motion termed bulk generated turbulence turbulent flows compendium eddies flow structures different length time scales contribute towards improved enhanced mixing momentum transfer heat transfer mass transfer transport phenomena hence proper understanding dynamics turbulent flow structures role transport phenomena bring substantial improvement scale design procedures present paper brings current status knowledge bubble generated turbulence published literature experimental measurements dns simulations critically analysed coherently presented elsevier ltd rights reserved
study presents importance disconnectivity dryland area runoff demonstrated manmade water harvesting structures dated greco roman times located coastal strip width along mediterranean coast modern northwestern egypt covering north eastern part region known antiquity marmarica area receives winterly rainfalls south precipitation decreases quickly desert conditions become pronounced bedrocks predominantly calcareous soils loamy stony calcareous shallow except relief sinks sedimentary deposits land rises coast marmarica plateau sequence zonal northsloping plains scarps northern parts dissected drained wadis agriculturally suitable areas comprise coastal zone adjacent tablelands overland flow controls discharge dynamics main source wadi runoff hence agricultural water supply land use pattern scattered cropping areas depend mainly suitability soils generation runoff harvest closely interrelated arid water sediment regime patchiness runoff generation increases south aridity higher topography inhibits greater drainage patterns abundance cisterns many originally greco roman strong evidence tableland overland flows occur frequently disconnected larger drainage systems abandoned ancient rainwater harvesting watershed management systems abundant region incorporate hydrological experience former inhabitants dated osl pottery mainly greco roman times region prospered two millenia ago ancient water management schemes generally abandoned today one outstanding features ancient systems systematic harvesting tableland valley slope overland flow wadi beds part strategy separate remote parts large natural watersheds local parts shallow stone bunds tableland collected tableland overland flow irrigated terraced fields tableland lairum remaining water harvesting areas mainly valley slopes obviously sufficient supply water small tributary wadis large side terraces floodplains large wadis artificial disconnection local runoff areas remote parts northern watersheds hydrologically well adapted runoff dynamics flat landscape northern marmarica protected valleys low frequency high magnitude runoff events generated mainly remote parts large catchments inefficient terms water harvesting terracing water harvesting structures frequently buried well sorted fine grained sediment elsevier rights reserved
paper output error method proposed identification continuous time systems time delay sampled data challenge time delay system identification lies presence nonlinear time delays models starting value based optimization methods may trapped easily local minima order improve convergence performance choice initial parameters several approaches smooth loss function presented shown loss function may possess many local minima data regularly sampled inter sample behavior zero order hold interestingly irregular sampling efficient approach overcome local minima achieve superior convergence performance parametrization approach incorporating low pass filtering technique proposed enlarge convergence region theoretical simulated results presented demonstrate effectiveness proposed method elsevier rights reserved
well established violent media increase levels aggression aim present study wars examine whether cognitive distortions mediate relationship enjoyment violent media frequency people exposed violent media whether exposure violent media mediates relationship cognitive distortions levels aggression eighty six participants completed questionnaires assessing enjoyment frequent exposure film television violence lyrical violence music computer game violence participants also assessed respect frequency aggression moral disengagement mediation analysis indicated partial mediation effects moral disengagement regarding relationship enjoyment violent media frequency exposure violent media full mediation effects moral disengagement frequency exposure violent media aggression relationship study emphasizes role cognitive distortions moral disengagement play digesting violent media making acceptable therefore increasing likelihood higher levels aggression
children developmental dyspraxia express impairments acquisition various motor skills development social cognition abilities although neural bases condition fully understood thought involve frontal cortical areas subcortical structures cerebellum although cerebellar dysfunction typically difficult assess quantify using traditional neurophysiological methods oculomotor analysis may provide insight specific cerebellar patterns aim present study investigate dyspraxic typically developing subjects various oculomotor saccade tasks specifically designed reveal frontal cerebellar dysfunction addition evidence supporting prefrontal dysfunction results revealed increased variability saccade accuracy consistent cerebellar impairments furthermore found dyspraxic patients showed decreased velocities non visually guided saccades closer analysis revealed significant differences saccade velocity profiles slightly decreased maximum saccade velocities markedly prolonged deceleration phases show pattern related decreased state alertness suggestive cerebellar dysfunction however clear predominance pattern non visually guided saccades warrants alternative hypotheses light previous experimental anatomical studies propose unusual pattern may consequence impaired connections frontal areas cerebellar oculomotor structures
background eating disorders eds common amongst women however research specifically investigated lifetime month prevalence eating disorders amongst women mid life fourth fifth decade life relevant longitudinal risk factors aimed investigate lifetime month prevalence eds lifetime health service use identify childhood parenting personality risk factors methods two phase prevalence study nested within existing longitudinal community based sample women mid life total women avon longitudinal study parents children alspac enrolled years earlier participated diagnoses obtained using validated structured interviews weighted analyses carried accounting two phase methodology obtain prevalence figures carry risk factor regression analyses results mid life confidence intervals women met criteria lifetime month prevalence eds childhood sexual abuse prospectively associated binge purge type disorders external locus control associated binge eating disorder better maternal care protective bulimia nervosa childhood life events interpersonal sensitivity associated eds conclusions mid life significant proportion women experience women accessed healthcare active eds common mid life due new onset chronic disorders increased awareness full spectrum eds stage life adequate service provision important first study investigate childhood personality risk factors full threshold sub threshold eds identify common predictors full sub threshold eds research clarify role preventable risk factors full sub threshold eds
gut microbiota lps contributes obesity related chronic inflammation oxidative stress promoting insulin resistance periodontal disease also represents risk factor type diabetes associated obesity study compared effect lps gingivalis periodontopathogen coil enterobacteria inflammatory adipokine secretion redox status adipocytes found lps activated tlr tlr mediated signaling pathways involving myd adaptor nfkb transcription factor leading increased secretion leptin resistin mcp effects partly blocked inhibitors targeting mapk jnk erk moreover gingivalis lps reduced adiponectin secretion lps also enhanced ros production expression nox nox inos genes gingivalis lps altered catalase gene expression collectively results showed lps periodontal bacteria induced pro inflammatory adipokine secretory profile oxidative stress adipocytes may participate obesity related insulin resistance elsevier rights reserved
reliable accurate noninvasive method identifying patients gastroesophageal reflux disease gerd primary care setting needed population based case finding instrument may assist managed care organizations identifying candidates disease management quality improvement programs aim develop validate gerd case finding instrument item gerd screener developed based literature review expert opinion questions heartburn regurgitation frequency severity medication use well demographics exclusion criteria categorical continuous scoring methods without medication use developed priori using telephone interview medical group identified enrolled subjects history gerd like symptoms controls subject completed gerd screener validated gastrointestinal symptom questionnaire digestive health symptom index dhsi evaluated independently two gastroenterologists using structured format agreement two physicians symptoms consistent gerd required intervention considered gold standard subjects classified gerd controls using gold standard kappa scoring method screening instrument using continuous measure gerd symptoms frequency severity weighted medication use resulted area roc using cutoff points measure sensitive specific compared gold standard dhsi gerd subscale area roc gerd screener highly correlated dhsi gerd subscale conclusion gerd screener demonstrated construct convergent predictive validity shorter existing validated instruments practical easily administered may reduce response administrative burden may serve valuable case finding instrument primary care managed care organizations wishing implement programs improve quality efficiency care
article focuses effects operational differences case ascertainment estimates prevalence incidence cognitive impairment dementia alzheimer type experience insights discussed investigators framingham heart study east boston senior health project chicago health aging project mayo clinic study aging baltimore longitudinal study aging aging demographics memory study general consensus single important factor determining prevalence estimates alzheimer disease severity cognitive impairment used threshold define cases studies require level cognitive impairment persons unable provide self care much lower estimates studies aimed identifying persons earliest stages limited autopsy data aforementioned epidemiological studies address accuracy diagnosis etiological subtype namely specification alone combination types pathology however community based cohort studies show many persons mild cognitive impairment also persons without dementia mild cognitive impairment meet pathological criteria thereby suggesting number persons would benefit effective secondary prevention intervention probably higher published prevalence estimates improved accuracy clinical diagnosis anticipated addition molecular structural biomarkers next generation epidemiological studies alzheimer association rights reserved
methane nitrous oxide two potent greenhouse gases highly heterogeneous distributions space time mapping hot spots source areas measuring fluxes different environments far possible local scale using direct measurements developed method simultaneous mapping methane nitrous oxide also including water vapor using ground based remote sensing landscape sized scale utilizing imaging fourier transform spectrometers ifts high spectral resolution imaging rates approach uses calculated libraries transmission spectra spectroscopic resolutions ifts based hitran database spectroscopic lines line line radiative transfer model lblrtm species spectra made resulting combinations column densities using adaptive grid solutions found line sight spectral resolution using full spectral region detector modeling multi layered calculating temperatures background air additional gas layers also accounting reflected cold sky background distances mapped amount water vapor line sight described approach used identify sources quantify gas distributions calculate fluxes visualizations produce gas distribution images well air motion videos used map fluxes using data set without need additional instruments wind measurements elsevier inc rights reserved
due increasing adoption immediate implantation strategies rapid development computer aided design computer aided manufacturing technology therapeutic concept based patient specific implant dentistry recently reintroduced many researchers however little information available designs custom made dental implant systems especially biomechanical behavior influence custom made implant designs biomechanical performance immediate delayed loading protocol maxillary esthetic zone evaluated means finite element method models three dental implants considered state art cylindrical implant two custom made implants designed reverse engineering technology namely root analogue implant root analogue threaded implant von mises stress distributions micro motions around bone implant interfaces calculated using ansys software comparison three implant designs loading protocols favorable biomechanical performance observed use root analogue threaded implant approximated geometry natural anterior tooth maintained original long axis results indicated bone implant interfacial micro motion reduced favorable stress distribution osseointegration achieved
microglia mediated neuroinflammation described common hallmark parkinson disease believed exacerbate progressive degeneration dopaminergic neurons current therapies unable prevent disease progression significant association demonstrated low levels vitamin patients serum vitamin supplement appears beneficial clinical effect herein investigated whether vitamin administered orally methyl phenyl tetrahydropyridine mptp induced preclinical animal model protects glia mediated inflammation nigrostriatal neurodegeneration vitamin significantly attenuated mptp induced loss tyrosine hydrlase positive neuronal cells microglial cell activation iba immunoreactive inducible nitric oxide synthase inos tlr expression typical hallmarks pro inflammatory activation microglia additionally vitamin able decrease pro inflammatory cytokines mrna expression distinct brain areas mptp mouse importantly also assessed anti inflammatory property vitamin mptp mouse upregulated anti inflammatory cytokines tgf beta mrna expression well increasing expression typical hallmarks alternative activation microglia anti inflammatory signalling collectively results demonstrate vitamin exhibits substantial neuroprotective effects animal model attenuating pro inflammatory regulating anti inflammatory processes
ethnopharmacological relevance plukenetia volubilis euphorbiaceae domesticated vine distributed high altitude andean rain forest lowlands peruvian amazon oil cold pressed seeds sold commercial name sacha inchi oil sio actually much favour contains high percentage omega omega hence used dietary supplement sio also used traditionally skin care order maintain skin softness treatment wounds insect bites skin infections tropical context skin frequently damaged aims study study designed order verify whether traditional use sio skin care would impact staphylococcus aureus growth skin adherence aureus involved many skin pathologies impetigo folliculitis furuncles subcutaneous abscesses one main pathogens found skin therefore objective assess sio bactericidal activity interference adherence human skin explants keratinocyte cell line cytotoxicity cells also determined activity sio compared coconut oil coco widely used skin care different unsaturated fatty acids contents materials methods laboratory testing certified oil determined antibacterial activity radio labelled aureus cytotoxic effects measured xtf keratinocyte cells neutral red human skin explants phenol used cytotoxic control adherence assays carried mixing labelled aureus bacteria keratinocyte cells human skin explants incubated oils determine inhibition adherence assimilated preventive effect contact biological material aureus assess detachment bacteria assimilated curative effect residual radioactivity measured washings made possible determine adherence intensity bactericidal effect determined colony counting trypticase soy agar results laboratory assays showed sio coco tested undiluted cytotoxic keratinocytes human explants bactericidal neither sio active antiadherent preventive coco keratinocytes significant difference detachment effects curative oils keratinocytes sio almost times active detachment aureus human skin explants conclusion study concluded use sio dermal cells safe efficient inhibition aureus adherence results tend support traditional use undiluted sio skin care elsevier ireland ltd rights reserved
paper examines recipients social work support millennium cohort study using panel analysis fixed effects models investigates factors lead receipt type social work support individuals young children effects support changes prevalence emotional behavioural problems children find divorce separation episodes homelessness two important factors lead receipt social work support mothers male children also likely receive social work support however find clear evidence social work support effect changes children emotional behavioural problems time implications findings social work research practice policy discussed
single system image computing paradigm number distributed computing resources aggregated presented via interface maintains illusion interaction single system approach encompasses decades research using broad variety techniques varying levels abstraction custom hardware distributed hypervisors specialized operating system kernels user level tools existing classification schemes ssi technologies reviewed updated classification scheme proposed survey implementation techniques provided along relevant examples notable deployments examined insights gained hands experience summarized issues affecting adoption kernel level ssi identified discussed context technology adoption literature elsevier inc rights reserved
building sector accounts substantial portion global greenhouse gas ghg emissions building facilities energy emission intensive construct operate embodied ghg emissions buildings make considerable portion life cycle emissions previous research indicates per cent life cycle emissions minimised careful selection low carbon materials although green building rating tools widely used identify mitigate life cycle environmental impacts building facilities existing tools including leadership energy environmental design leed proven unsatisfactory auditing benchmarking embodied ghg emissions buildings study begins examining limitations current green building rating tools particular means evaluating embodied ghg emissions buildings embodied ghg emissions assessment module existing green building rating tool leed proposed proposed embodied ghg emissions assessment module enable clients design teams minimise carbon footprints buildings assist users general public identifying low carbon building facilities elsevier ltd rights reserved
aim prospectively evaluate postoperative morbimortality weight loss evolution patients underwent laparoscopic sleeve gastrectomy lsg primary bariatric procedure years follow methods since data patients undergoing highly restrictive primary lsg prospectively registered database analysed preoperative morbid conditions operating time hospital stay early late complications rate evolution weight loss years follow analysed results total patients included women mean age years mean body mass index bmi seventy patients presented bmi mortality rate leakage rate total morbidity rate mean follow range mean percent excess weight loss ewl year years years mean percent excess bmi loss ebmil year years years patients preoperative bmi less achieved greater weight loss overall study population diabetes remitted patients hta improved cpap masks withdrawn patients obstructive sleep apnoea conclusion lsg built narrow bougie starting pylorus proved safe highly effective terms weight loss stand alone procedure particularly patients preoperative bmi lower key words sleeve gastrectomy morbid obesity bariatric surgery obesity surgery laparoscopy long term results year results author published baishideng publishing group inc rights reserved
parkinson disease progressive neurodegenerative disease characterized rigidity bradykinesia resting tremor postural instability rigidity defined increased resistance passive movement joint progresses faster motor signs rigidity attributable exaggerated neural reflex altered muscle mechanical properties however little known contributions individual components rigidity evidence regarding effects dopaminergic medication individual components objectives study quantify contributions neural reflexes intrinsic muscle properties rigidity investigate effects medication contributing component joint torque muscle activities wrist patients controls measured externally induced movements subject tested medication states system identification technique applied differentiate quantify neural reflex intrinsic mechanical components mixed model anova performed compare differences two components rigidity groups compare medication states patients results showed reflex intrinsic components comparable enhanced subjects controls medication decreased reflex component rigidity concluded reflex intrinsic factors responsible rigidity present findings clinically significant may provide guidance development effective therapeutic interventions
diagnosis management attention deficit hyperactivity disorder adhd adults complex challenging frequent comorbidity psychiatric disorders symptoms overlapping adhd presence comorbidities create challenges making accurate diagnosis also impact treatment options outcomes review discusses disorders may comorbid adhd adults including anxiety mood substance use disorder antisocial personality disorder borderline personality disorder suggestions recognizing comorbidities distinguishing adhd perspectives possible impact adhd treatment included adjunctive nonpharmacologic modalities may especially helpful case comorbid mood anxiety substance abuse personality disorders
young leaves shoots sibiraea laevigata known liucha used tea tibetans improve digestion meals long term consumption liucha cause weight loss present work reported isolation nmr chemical analysis based elucidation seven new sorbitol caffeic acid ester derivatives named sorbitol esters eighteen known phenolic compounds laevigata isolates evaluated antioxidant alpha glucosidase inhibitory activities among sorbitol ester sorbitol ester sorbitol ester sorbitol ester isoferulic acid methyl caffeate trans hydroxycinnamic acid kaempferol beta coumaroyl glucopyranoside showed potent glucosidase inhibitory activity clinical drug acarbose elsevier ltd rights reserved
equivalent input current noise bandwidth relevant parameters qualifying low noise transimpedance amplifier conventional topology consisting operational amplifier shunt shunt configuration equivalent input noise decreases feedback resistor also sets gain increases unfortunately increases omega required obtaining high sensitivity bandwidth system set parasitic capacitance reduces increases paper propose new topology allows overcoming limitation employing large bandwidth voltage amplifier together proper modified feedback network compensating effect parasitic capacitance feedback resistance experimentally demonstrate prototype circuit proposed approach allows obtain bandwidth excess khz equivalent input noise root corresponding current noise omega resistor part feedback network new approach allows obtaining larger bandwidth respect obtained previously proposed configurations comparable background noise copyright john wiley sons ltd
satellite systems offer several advantages wireless internet communications nevertheless satellite radio links affected two severe problems namely long propagation delays relatively high error rates pose difficult challenge internet protocols particular tcp among potential solutions specifically interested tcp enhancements preserve end end semantics tcp paper authors evaluate performance improvements provided additional features applied tcp west wood tcpw promising transport protocol specifically designed cope errors wireless links enhanced version tcpw compared original tcpw known tcp variants newreno sack hybla considering goodput fairness friendliness performance figures results obtained simulations seem encouraging suggest inclusion proposed additional features future official versions tcpw
borderline personality disorder complex disease model encompasses diversity pathological personality traits psychopathological symptoms surprising therefore often manifested personality disorders across three clusters accompanied mental axis disorders melange makes psychological treatment pharmacotherapy especially challenging paper describes case particularly complex case year old romanian patient history severe deprivation childhood mood substance use disorder association borderline pathology course treatment many sources interventions become clear dependence key component pathology rewarded degree success management copyright john wiley sons ltd
background although meningioma common disease lack understanding underlying molecular mechanisms behind initiation progression used combined mirna mrna transcriptome analysis discover dysregulated genes networks meningiomas methods fourteen fresh frozen meningioma samples one human meningeal cell line analyzed using mirna whole transcriptome microarray chips data filtered analyzed candidate mirnas mrnas selected validation fifty eight patient samples mirna target mrna relationships assessed inhibiting mirna meningioma cells apoptosis viability assays also used functional tests results whole transcriptome microarray genes found dysregulated mirnas found dysregulated result mirna microarray results combined analyzed bioinformatics tools top differential pathways included inflammation cancer cellular growth survival oncosupressor ptx constitutively low meningioma samples moreover ptx negatively correlated mir samples inhibiting mir upregulated ptx level induced apoptosis meningioma cells decreased cell viability cabin mir tmod ptx rpl sparcl rela correlated clinicopathological features patient samples conclusions results present first integrated mrna mirna analysis meningiomas mir ptx inversely correlated tissues meningioma cells hinting ptx regulated mir furthermore determined potential clinicopathological markers
study waste tire powder waste liquid crystal display lcd glass sand used recycled materials fixed water binder ratio use fly ash slag cement replacement materials waste tire powder waste lcd glass sand passed sieve screen size used replace fine aggregates producing lightweight aggregate concrete fresh property test processed accordance aci concrete mix proportion design harden durability tests performed days results showed slump increased decreased addition different types recycled materials still met design slump concrete workability unit weight decreased adding rubber powder concrete replacement rates waste glass sand waste rubber powder increase compressive strength tends decrease days ultrasonic wave velocity normal concrete higher lightweight aggregate concrete lightweight aggregate concrete glass sand provided highest ultrasonic wave velocity lightweight aggregate concretes sulfate resistance tests showed normal weight aggregate concrete better lightweight aggregate mixing two kinds recycled materials also resulted better resistance studies showed adding appropriate amount recycled materials might improve durability lightweight aggregate concrete elsevier ltd rights reserved
practitioners researchers alike face challenge different sources report inconsistent information regarding child maltreatment present study capitalizes concordance discordance different sources probes applicability multisource approach data three perspectives maltreatmentchild protection services cps records caregivers children sample comprised participants early childhood year olds late childhood adolescence year olds two cps sites community oversampled psychosocial risk established three components within factor analytic approach shared variance sources presence maltreatment convergence nonshared variance resulting child perspective caregiver versus cps perspective shared variance sources strongest predictor caregiver self reported child symptoms child perspective caregiver versus cps perspective mainly added predictive strength symptoms late childhood adolescence convergence case emotional maltreatment lack supervision physical abuse contrast convergence almost fully accounted child symptoms failure provide results suggest consistent information different sources reporting maltreatment average best indicator child risk
parents use opioids involved child welfare system less likely retain custody children parents use drugs previous studies described medication assisted treatment mat utilization child permanency outcomes population sobriety treatment recovery team start model child welfare based intervention focused families occurring substance use child abuse neglect issues study examined prevalence correlates mat utilization among parents start program history opioid use compared child outcomes families received mat services individuals history opioid use start program received mat receipt mat services differ gender age county residence drug use though individuals identified white likely participate mat multiple logistic regression model additional months mat increased odds parents retaining custody children address barriers mat results focused educational interventions may needed child welfare workforce well programs improve collaboration decision making child welfare workforce court personnel drug addiction treatment providers elsevier inc rights reserved
netherlands western european countries desirability governability multicultural society topics debate last decade debate increasingly centred second generation migrants focusing high rates crime school drop dutch context however little scholarly research paid attention second generation migrants experiences paper therefore focus perceptions ethnic boundaries held year old second generation migrants negotiate boundaries low income multi ethnic feijenoord area rotterdam study shows young people used living together many different cultures see sides ethnic boundary dutch majority society culture parents however also encounter prejudice discrimination day day lives calls question success multiculturalism
paper presents study accommodate wind power multiple regions simultaneously implementing economic reliable dispatch multi area power system operation focus quantifying operational risk brought wind power uncertainty time accommodating wind power coordinating multi area generation reserve resources reserve requirement area calculated based two indexes namely loss load probability wind spillage probability generation reserve cooptimization dispatch model factors cross regional wind power accommodation proposed transmission margin network security constraints tie lines considered systematically allocate reserve resources areas finally optimality condition decomposition used decompose dispatching model achieve relatively independent regional scheduling get global optimization result reasonableness effectiveness proposed approach validated bus area test system bus interconnected system
sustainability concept gained recognition indonesia contractors slowly implementing principles construction projects assessment model developed tool identify baseline conditions contractors readiness awareness willingness capacity towards sustainability practices model involves parameters indicators derived green building green contractor concepts sustainable construction best practices scoring system parameters indicators set discussions experts using delphi method facilitated ministry public works trial surveys conducted refine model preliminary portrayal existing conditions indonesia assessed using proposed readiness assessment model limited survey indicated large contractors fully aware willing partly implementing sustainability practices process developing model involved experts champions industry stakeholders also led government ministry public works proposed assessment model inherently acceptable industry wide application
purpose purpose paper examine factors influencing defaults exits public works prime contractors small medium sized enterprises japanese construction industry analysing data several years panel data study determines extent influence changes company characteristics defaults exits design methodology approach using construction company evaluation keiei jikou sinsa keisin data employing panel binary logit random effect model study empirically analyses construction industry findings study shows defaulting exiting companies different characteristics result shows financial performance indicators non financial performance indicators keisin scores significantly affect defaults exits particular study finds non financial performance indicators whether firm draws insurance significantly affect likelihood default exit influence varies basis insurance type originality value feature study analysis focuses defaulting companies also exiting companies defined stop operating prime contractors public works otherwise stay business contrast existing research study distinguishes defaults exits analyses factors influence firm following one two outcomes moreover although keisin data usually used determine whether companies qualify enter bids public works applied attribution analysis corporate defaults exits
many graphics also non graphics applications need efficient techniques find nearest neighbors given query point two approaches address problem space partitioning data partitioning present data partitioning error controlled strategy solving nearest neighbor search nns problem using spatial sorting basic building block improve neighborhood grid method extensive study novel spatial sorting strategies bidimensional nns providing significant performance precision gains previous works experiments demonstrate many dense point distributions solution competitive complex traditional techniques trees index sorting also show comparable results case primary contribution dynamic simple implement memory efficient highly parallelizable solution low dimensional approximate nearest neighbor search elsevier ltd rights reserved
obesity metabolic syndrome type diabetes related disorders widespread deleterious effects throughout body one important target damage brain persons metabolic disorders significantly increased risk cognitive decline development vascular dementia alzheimer disease review available evidence epidemiologic clinical basic research suggests neural dysfunction related disease results several underlying mechanisms including metabolic inflammatory vascular oxidative changes relationships neural dysfunction regulated several modifiers emphasize modifiers genetic risk factor apolipoprotein agerelated endocrine change low testosterone factors independent risk factors alzheimer disease may also cooperatively regulate pathologic interactions dementia continued elucidation links metabolic disorders neural dysfunction promises foster development effective therapeutic strategies
cryptococcosis fungal infection caused cryptococcus spp enters body via inhalation ubiquitous yeast gained notoriety opportunistic pathogen immunosuppressed population authors report case previously well adult male presented left sided weakness imaging demonstrated pulmonary mass contrast enhancing intracranial lesions features suggestive primary lung carcinoma brain metastases however investigations confirmed disseminated cryptococcosis without evidence malignancy patient successfully treated course antifungals authors knowledge first reported case dissemintated cryptococcosis immunocompetent adult male simulating primary lung carcinoma brain metastases elsevier ltd rights reserved
proffering context awareness facilities end users long term objective ambient intelligence ami context aware system know context information understand exactly happening particular environment order build provide distinct capabilities users occupants environment however multiple challenges precisely capturing context activity details sensors actuators deployed environment possibilities aggregating wrong data due various reasons different levels sensor network etc several technologies mathematical concepts recommended substantially enhance quality sensor actuator data decisions derived data collected right concept fuzzy finite automata used researchers solve issues trustworthiness timeliness sensor data turned complex affair paper empowered deterministic finite automata dfa threading enable correct decision making data multiple sensors devices environment short considering multiplicity heterogeneity devices personal well professional environments dfa parallelization capability going novelty game changer precision centric context aware computing suggested method verified validated freely obtainable data set results obtained prove simplicity correctness solution approach
computational complexity public key cryptography sensor nodes anymore blocking concern modern devices natively efficiently support elliptic curve cryptography problem rather shifted toward significant airtime consumption required exchange multiple messages certificates perform authentication key agreement letter addresses problem exploiting implicit certificates elliptic curve vanstone specifically propose novel key management protocol kmp suitably integrates implicit certificates standard elliptic curve diffie hellman exchange performs authentication key derivation confirmed proof concept implementation relevant experimental results proposed kmp guarantees maximal airtime savings respect conventional approaches robust key negotiation fast rekeying efficient protection replay attacks
introduction integration patient caregiver input guideline development help ensure clinical care addresses patient expectations priorities needs aimed identify topics outcomes salient patients caregivers inclusion kidney health australia caring australasians renal impairment kha cari clinical practice guideline screening management infectious microorganisms hemodialysis units methods facilitated workshop conducted participants patients caregivers participants identified discussed potential topics inclusion guidelines compared developed guideline working group workshop transcript thematically analyzed identify describe reasons underpinning priorities findings patients caregivers identified range topics already covered scope proposed guidelines also suggested additional topics privacy confidentiality psychosocial care disease notification quality transportation psychosocial treatment patients isolation patient caregiver education engagement patient advocacy five themes characterized discussion underpinned choices shock vulnerability burden isolation fear infection respect privacy confidentiality confusion procedural inconsistencies discussion patients caregivers emphasized need guidelines address patient education engagement psychosocial implications communication provision care context infectious microorganisms hemodialysis units integrating patient caregiver perspectives help improve relevance guidelines enhance quality care patient experiences health psychosocial outcomes
multi vent regulators widely used egypt operation system gates affects characteristics flow downstream multi vent regulators current study aimed toward introducing artificial intelligence technique new modeling tool prediction characteristics flow downstream multi vent regulators management operating systems multi gates specially artificial neural network ann utilized current study conjunction experimental data predict relative length submerged hydraulic jump occured multi vent regulators different cases gates operation results show ann technique successful simulating relative submerged hydraulic jump length occurred stilling basins downstream multi vent regulators better multiple linear regression mlr faculty engineering shams university production hosting elsevier
cosmetopea regards fitchia nutans asteraceae endemic plant previously used skin care ingredient included sacred traditional monai preparation french polynesia led investigate cosmetoceutical properties extract leaves nutans submitted anti ageing activity assays using vivo human skin tests evidenced potential stimulate collagens elastin dermal growth report herein first phytochemical study plant extract showing main constituents sesquiterpenoids including new natural product compound isovaleroyloxydihydrocostunolide phenylpropanoids phenolic derivatives academie des sciences published elsevier masson sas
purpose review progressive ankylosis feared consequence long standing axial spondyloarthritis aim critically review current insights effect therapy molecular pathways involved process present model explaining sequence events recent findings long term follow data suggest successful control inflammation may slow radiographic progression disease axial spondyloarthritis structural effects new therapies interleukin targeting need studied bone loss architectural changes could act driver tissue remodeling process trying maintain spinal stability presence inflammation summary despite progress nature mechanisms new bone formation axial spondyloarthritis still remain incompletely understood however long term control inflammation appears critical avoid progressive disability due structural damage
proportional integrative derivative pid controllers among used industrial control applications classical pid controller design methodologies significantly improved incorporating recent computational intelligence techniques two techniques based particle swarm optimization pso algorithms proposed design pid controllers control design methodologies directed optimize pid controller gains using two degrees freedom control configurations subjected frequency domain robustness constraints first technique proposes single objective pso algorithm sequentially design two degrees freedom control structure considering optimization load disturbance rejection followed set point tracking optimization second technique proposes many objective pso algorithm design two degrees freedom control structure considering simultaneously optimization four different design criteria many objective case control engineer may select adequate solution among resulting optimal pareto set simulation results presented showing effectiveness proposed pid design techniques comparison classic optimization based methods
buffeting response suspension bridge complex terrain studied based full scale data sonic anemometers accelerometers installed lysefjord bridge norway influence topography wind field associated effects displacement response investigated two main wind conditions observed display different characteristics requires case case approach refined description wind coherence identification mode shapes modal damping ratios carried using ambient vibration data verification procedure buffeting response bridge computed frequency domain compared recorded response terms standard deviation power spectral density displacement response overall comparison found satisfactory although discrepancies observed attributed large yaw angles non stationary wind fluctuations caused influence complex topography flow properties elsevier ltd rights reserved
processing time become increasingly major factor computed tomography hence need reconstruction real time diagnostics since filtered back projection algorithm fbp requires significantly intensive computational time amount data becomes increasingly large case computed tomography parallel computing technique used mat lab enables implementation multi tasking exploiting advantage partitioning input data allowing core cluster work sub image therefore fbp algorithm applied simultaneously cores reconstructed sub images sent client order gathered comparison results sequential fbp algorithm parallel algorithm show parallel computing process seven times efficient sequential algorithm voluminous images size otherwise small images results poor workers intercommunications require times comparing sequential algorithm takes short computational time
message middleware important branch middleware provides development distributed application system asynchronous pine programming architecture consistent thought development trend modern software technology widely used industry enterprise application integration distributed computing message bus message middleware kind simple implementation unique advantages wide variety distributed applications development injected strong power greatly promote development application system integration paper mainly focusing key issues involved middleware message bus concurrency model research
multilevel spin toque transfer ram stt ram suitable storage device energy efficient neural network accelerators nnas relies large capacity chip memory support brain inspired large scale learning models conventional artificial neural networks current popular deep convolutional neural networks paper investigate application multilevel stt ram general purpose nnas first error resilience feature neural networks leveraged tolerate read write reliability issue multilevel cell stt ram using approximate computing induced read write failures expense higher storage density effectively masked wide spectrum applications intrinsic forgiveness second present precision tunable stt ram buffer popular general purpose nna targeted stt ram memory design able transform multiple working modes adaptable meet varying quality constraint approximate applications lastly reconfigurable stt ram buffer enables precision scaling nna also provides adaptiveness demand different learning models distinct working set sizes particularly demonstrate concept capacity precision tunable stt ram memory emerging reconfigurable deep nna elaborate data mapping storage mode switching policy stt ram memory achieve best energy efficiency approximate computing
many individuals experience long term quality life qol impairment following anterior cruciate ligament reconstruction aclr factors contributing poor qol psychological health years aclr remain unclear study aimed describe qol psychological health outcomes people knee difficulties pain symptoms functional limitations years following aclr identify factors explaining variability outcomes participants knee difficulties years following aclr completed battery validated patient reported outcomes including knee injury osteoarthritis outcome score koos acl qol assessment qol aqol instrument multivariable linear regression used identify factors explaining variability outcomes one hundred sixty two participants aged mean years completed questionnaires range years following aclr thirty nine percent participants returned competitive sport returned lower level return sportafter aclr returning sport aclr associated worse koos qol mean acl qol aqol scores increased body mass index overweight obese related worse qol depressive symptoms subsequent knee surgery contralateral aclr also associated poorer qol outcomes individuals
phase retrieval problem recovering image fourier magnitudes important issue several algorithms proposed address problem recent efforts exploiting sparsity developed improve performance algorithms reconstruction quality robustness noise convergence behavior paper propose novel sparsity based algorithm adaptively learn orthogonal sparsifying transform reconstruct image simultaneously fourier magnitudes however estimated images early iterations extremely bad training samples images provide much useful information sparsifying transform learning avoid unnecessary updating orthogonal sparsifying transform learning method based transfer learning proposed transfer learning transfer fixed sparsifying transform adaptive one apply new sparsifying transform learning method exploit alternating directions method multipliers admm technique solve formulated problem since learnt sparsifying transform adaptive data favors better sparsity using learnt sparsifying transform image reconstruction improve reconstruction quality low oversampling ratios experimental results show proposed algorithm improve nearly compared recently proposed tihp algorithm terms average psnr peak signal noise ratio oversampling ratio moreover algorithm robust noise better convergence behavior heuristically elsevier inc rights reserved
many companies pay great deal attention existing customers referral intentions attempt attract new customers however little known necessary level satisfaction existing customers understand existing customers likely complete referral mechanism study assumed referral routes established model predicting referral intentions based satisfaction level described disconfirmation expectation theory net promoter score theory routes verified surveying construction management clients using structural equation modeling prediction model tested applying clients using multinomial logistic regression results indicated accuracy rate prediction model model used effectively attract new clients particularly fields long term services provided allows service providers predict customers referral intentions depending satisfaction levels american society civil engineers
paper presents generalized mixed radix decimation time dit fast algorithm computing modified discrete cosine transform mdct composite lengths odd positive integer proposed algorithm merits parallelism numerical stability also needs less multiplications type discrete cosine transform dct type discrete cosine transform dct based mdct algorithms due optimized efficient length modules computation mdct composite lengths realized combining proposed algorithm fast radix mdct algorithm developed combined algorithm used computation length mdct used mpeg layer iii audio coding well recently established wideband speech audio coding standards length mdct used realization inverse mdct imdct obtained transposing signal flow graph mdct elsevier rights reserved
background may link right left shunt rls brain white matter lesions wmls patients migraine study assessed relationship wmls rls japanese migraine patients methods total consecutive patients migraine without aura mwoa included study contrast transcranial doppler ultrasound used detect rls wmls graded using brain magnetic resonance imaging based well established criteria findings prevalence rls significantly increased wmls positive group compared wmls negative group prevalence wmls mwoa patients statistical differences logistic regression analysis adjusted age disease duration migraine identified rls positive status sole determinant presence wmls conclusion study suggests possible link rls wmls japanese patients migraine
shannon cipher system memoryless sources distortion allowed legitimate decoder considered source compressed using secured rate distortion code satisfies constraint compression rate well constraint exponential rate excess distortion probability legitimate decoder secrecy measured exponential rate exiguous distortion probability eavesdropper rather traditional measure equivocation perfect secrecy exponent defined maximal exiguous distortion exponent achievable key rate unlimited reproduction based estimate exponent defined maximal exiguous distortion exponent achievable genie aided eavesdropper knows secret key limited key rate proved maximal achievable exiguous distortion exponent equal minimum key rate plus reproduction based estimate exponent perfect secrecy exponent result generalized fairly general class variable key rate coding rate codes
study done investigate osteoporosis prevalence hip fracture admissions trauma unit assiut university hospitals associated factors understudied locality prevalence female sex older age low body mass index fall ground associated osteoporosis purpose study aims identify osteoporosis prevalence hip fracture admissions trauma unit assiut university hospitals study independent correlates osteoporosis related fracture methods prospective cross sectional study carried hip fracture patients admitted trauma unit assiut university hospitals january december sexes aged years older exclusion criteria polytrauma major accidents history chronic conditions long term medication associated osteoporosis risk increase bilateral hip fractures every patient weight height bone mineral density dual energy ray absorptiometry dexa recorded tests significance non parametric data used questionnaire included sociodemographic characteristics dietary habits lifestyle factors smoking physical activity female obstetric gynecological factors results mean age males obese fall ground fractures osteoporosis femoral neck tscore prevalence univariable analysis significant correlates female gender older age normal bmi fall ground milk cheese daily intake significantly associated lower prevalence osteoporosis multivariable logistic regression model female sex older age low bmi fall ground associated osteoporosis conclusions osteoporosis prevalence high among hip fracture patients associated female sex increase age low bmi fall ground strategies prevent osteoporosis needed decrease hip fracture rates
bilateral eye movements ems shown induce cognitive enhancements episodic memory attention divergent thinking increased interhemispheric interaction suggested possible mechanism behind effect theories including increase attentional control following ems also proposed present research explored whether bilateral effect could extended creativity task draws heavily convergent thinking participants randomly assigned one four conditions bilateral centre control right centre left centre presented compound remote associate problems participants asked make solution non solution judgement target word presented left right visual field bilateral right centre conditions exhibited enhanced performance task bilateral condition demonstrating best performance solution targets right centre condition presenting best performance non solution targets implications findings discussed light neural components creativity theories surrounding effects ems cognition
objectives investigate plasma ghrelin obestatin levels ghrelin obestatin prepropeptide gene polymorphisms sequentially enrolled small gestational age sga infants methods neonates sequentially enrolled study subdivided different groups according different study aims availability study materials consequently plasma ghrelin obestatin levels measured term sga term appropriate gestational age aga term large gestational age lga preterm sga preterm aga neonates levels peptides also measured aga infants different gestational ages term aga neonates different days following birth three ghrelin obestatin prepropeptide gene single nucleotide polymorphisms snps arggln leumet glnleu measured neonates results study involved total cohort neonates neonates term aga term sga term lga preterm aga preterm sga plasma obestatin levels significantly higher term sga versus term lga neonates versus respectively wider cohort significant differences genotypes allele frequencies arggln leumet glnleu snps term sga aga neonates preterm sga aga neonates conclusions ghrelin obestatin prepropeptide polymorphisms found associated sga status neonates however ghrelin obestatin levels may involved growth development studies required understand relationship ghrelin obestatin prenatal development
background patients inflammatory bowel disease ibd irritable bowel syndrome ibs access growing number probiotic products marketed improve digestive health unclear patients make decisions probiotics role expect gastroenterologists play consider using probiotics understanding patients knowledge attitudes expectations probiotics may help gastroenterologists engage patients collaborative discussions probiotics study focus groups conducted patients ibd ibs cleveland clinic mayo clinic johns hopkins university inductive analytic methods used identify common themes draw interpretations focus group narratives results one hundred thirty six patients participated focus groups march august patients viewed probiotics appealing alternative pharmaceutical drugs understood probiotics natural low risk therapeutic option many patients hesitant use without consulting gastroenterologists patients would weigh risks benefits probiotics disease severity satisfaction current treatments considering probiotic use conclusions patients interested probiotics many unanswered questions use findings suggest patients ibd ibs look gastroenterologists clinicians trustworthy advisors regarding utility probiotics alternative supplement pharmaceutical drugs gastroenterologists clinicians care patients diseases prepared discuss potential benefits risks probiotics assist patients making informed decisions use
paper dimensioning details linear electrical machines provided application free piston generator fpg free piston generator integrates functions combustion engine crankshaft connecting rod rotating electrical generator used conventional hybrid schemes single unit promising applications series hybrid vehicles distributed generation units previous work authors investigated surface mounted moving magnet machines synchronous reluctance moving iron machine moving coil linear induction machines continuation work buried magnets moving magnet machines switched reluctance hybrid reluctance moving iron machines moving coil machines field excitation magnets stator investigated found transverse flux machines tfm surface mounted buried magnet designs promising far fulfilment system specifications concerned transverse flux machines finite element verification analytical results always required single pole surface mounted tfm simulated fem found fem results closely follow analytical models verifying promising behaviour tfm however since machines low power factor recommended find measures counter drawback
use ethnic imagery visual identities brands used professional sports franchises long contentious issue american society research investigates oft voiced argument ethnic brand imagery perpetuates negative stereotypes claim subject little empirical scrutiny identifies conditions encountering brand imagery strengthens positive negative implicit stereotypes within context american indian brand imagery two laboratory experiments studies quasi experimental field study study revealed effects ethnic brand imagery stereotypes depend viewer political identity exposure ethnic brand imagery strengthened implicit stereotypes among liberal individuals consistent idea liberals tend hold malleable views findings demonstrate measurable negative effects ethnic brand imagery implicit stereotypes support view use imagery carry detrimental societal consequences society consumer psychology published elsevier inc rights reserved
sflash instance famous multivariate public key cryptographic schemes chosen nessie cryptographic project european consortium candidate signature algorithm used digital signatures limited resource devices recently successful private key recovery attack sflash proposed bouillaguet fouque macario rat uncovering kernel properties quadratic forms central map expensive step attack calculation kernel vectors skew symmetric matrices bivariate polynomial ring bouillaguet proposed two methods accomplish computation methods involve symbolic computation bivariate polynomials first method computes characteristic polynomials matrices polynomials expensive second method involves grobner basis computation complexity difficult estimate paper show critical step calculating kernel vectors done numerical computation field elements instead symbolic computation method uses nondeterministic interpolation polynomial vectors called projective interpolation complexity explicitly evaluated experiments show much faster making total attack sflash times faster critical step times faster first method bouillaguet new method also slighter faster second method
paper describes implementation process domain specific computer programming language building environment rule analysis bera language growing area building information modeling bim need develop highly customized domain specific languages handling issues building models architecture engineering construction aec industry sector bera language one domain specific languages deals building information models intuitive way order ensure quality design assess design programming requirements using user defined rules early design phases accomplish goals bera language provides capabilities effectiveness ease use without precise knowledge general purpose languages conventionally used bim software development furthermore design implementation bera language focuses building objects associated information rich properties relationships paper represents implementation issues bera language associated building information models mapping building data structure instantiation execution addition portability language extensibility platform dependent issues involved bera language implementation implementation described paper based use industry foundation classes ifc given building information models solibri model checker smc ifc engine java virtual machine jvm compilation execution environment
shadow banking entities repeatedly charged breaking recent financial crises paper examines contribution money market funds important part shadow banking entities systemic risk united kingdom using covar methodology adrian brunnermeier using sample money market funds continuously listed investigate impact institutional corporate variables systemic risk results show liquidity mismatch increases average systemic risk whole period decreases risk great financial depression crown copyright published elsevier inc rights reserved
introduction polysubstance use disorder prevalent treatment seeking patients substance use disorder sud higher risk developing comorbid psychiatric symptoms pervasive deficits cognitive functions inferior treatment results present study investigates individuals polysubstance use disorder achieve least one year abstinence show greater improvements satisfaction life executive functions psychological distress compared relapsers controls prospective recovery polysubstance use disorder assessed broad output indicators remains understudied better understanding pattern recovery chosen output indicators could shed light recovery process group patients material methods investigated changes satisfaction life executive functions psychological distress period months patients remained abstinent relapsed subjects polysubstance use disorder recruited outpatient residential treatment facilities healthy controls recruited posters exhibited social welfare offices executive functions assessed behaviour rating inventory executive function adult self report version brief psychological distress symptom checklist scl satisfaction life satisfaction life scale swls substance use assessed self reports alcohol use disorders identification test audit drug use disorders identification test dudit participants categorized relapsers audit score dudit score women men results results indicated abstinent group greatest improvement indicators compared relapsers controls participants successfully quit substance use one year showed improved satisfaction life executive functions psychological distress compared participants relapsed controls conclusions study provides support view clinically statistically significant recovery satisfaction life executive functions psychological distress sud patients following one year abstinence knowledge highlights importance time continued abstinence findings suggest gradual careful step learning requirement adopted sud treatment initially focus stabilizing patient achieving abstinence interventions morbid problems cognitively demanding treatment components likely succeed later treatment sequence authors published elsevier inc
holistic farming systems provide designs whole farm make long term sustainable use nutrients water labour finances energy using organic residues produce energy safely recycling digested residues back farming system biogas digester could central component many holistic systems paper discusses influence environmental socioeconomic cultural constraints use biogas digesters holistic farming systems sub saharan africa higher altitude areas maintenance optimal temperature constrain anaerobic digestion floating drum fixed dome digesters better option flexible balloon digesters less susceptible temperature changes water key constraint rainwater harvesting could used reduce additional labour needed collect water energy limiting resource farming system optimum use organic residues might fuel anaerobic digestion whereas water limiting energy production burning pyrolysis might better option bioslurry anaerobic digestion used fish ponds produce plankton feed fish applied fertile fields fields intermediate fertility biochar pyrolysis better used improve soil infertile fields labour limiting particularly important system design minimises additional labour needed process organic residues daily basis considering trade offs labour resources elsevier ltd rights reserved
sustainable drainage systems suds best management practices increasingly used ecological engineering techniques prevent contamination receiving watercourses groundwater permeable paving suds technique commonplace car parks driveways minor roads one functions improve quality urban runoff however little known water quality benefits incorporating upper geotextile within paving structure review focuses five different categories pollutants organic matter nutrients heavy metals motor oils suspended solids originating street dust chloride paper critically assesses results previous international tests draws conclusions scientific rigour significance data findings indicate studies undertaken address role geotextiles directly indications presence geotextile leads minor water quality improvements example suspended solids held back geotextile solids sometimes contain organic matter nutrients heavy metals however studies inconclusive data often unsuitable statistical analysis long term research industry relevant statistically scientifically sound experimental set ups recommended
aimed examine general health intestinal physiology young old non human primates comparable life histories dietary environments vervet monkeys chlorcebus aethiops sabaeus stable comparable social nutritional environments selected evaluation health phenotype circulating cytokines biomarkers microbial translocation measured subsets monkeys additionally intestinal motility intestinal permeability fecal microbiomes characterized outcomes document age related intestinal changes present absence nutritional stressors known affect gastrointestinal motility microbiome found old monkeys greater systemic inflammation poor intestinal barrier function compared young monkeys old monkeys dramatically reduced intestinal motility changes motility present without large differences fecal microbiomes conclude deteriorating intestinal function feature normal aging could represent source inflammatory burden yet explained disease diet normal aging human primate populations intestinal changes seen independent dietary influences aging within consistent environment appears avoid major microbiome shifts data suggests interventions promote intestinal motility mucosal barrier function potential support better health aging
paper investigates fundamental limits communication electrical multiple input multiple output mimo networks information transmission associated energy exchanges first develop computation shannon capacity mimo wideband frequency dependent time invariant channel gives fundamental equations linking achievable bit rate needed power distribution necessary bandwidth equations specialized general cascade electrical stages detailed tackle case specific lumped elements circuit reference circuit effectiveness method demonstrated addressing simple cases highlight role different kinds coupling electrical paths finally case transmission intra chip buses realized real world silicon technology addressed effect massive parallelism discussed
functional activity cerebral cortex depends number type neurons including synapses transmitters wiring cerebral cortex high importance function prenatal development process genetically controlled environmental factors play important role formed neural circuits networks possess ability reorganization postnatal life formation new synaptic contacts elimination synapses epigenetic factor social interactions produce changes synaptic level play role learning capacity memory behaviour different areas lobes cerebral cortex responsible number different functions motor sensory functions vision auditory information taste olfaction intellect behaviour emotions creative thoughts planning language recognition orientation many others association areas take large part cerebral cortex stimulation brain means active verbal interaction child would develop mental capacity abnormalities cerebral cortex established schizophrenia bipolar disorder unipolar depression possible build better brain adult means daily mind gym mental physical activity intensive social contacts necessary protection cerebral cortex aged individuals brain plasticity starting prenatal development till end life must taken consideration
gambling associated various social behavioral problems previous analyses limited sample bias regarding gambling symptom severity range role antisocial personality disorder aspd study utilized nationally representative data set examined various characteristics behavioral problems aspd among five gambling severity groups participants individuals took part national epidemiologic survey alcohol related conditions nesarc provided information social behavioral problems aspd gambling using dsm criteria derived five gambling groups total sample non gambling low risk risk problem pathological gambling associations problematic behaviors nearly every gambling severity level significant prior adjustment sociodemographic variables aspd following adjustment significant associations persisted exception sexual coercion adjusted model financially oriented behaviors strongest associations gambling gambling severity levels associated increased risk number problematic behaviors social problems comparison non gamblers examination gambling problems financial criminal justice settings recommended elsevier ireland ltd rights reserved
future internet integrate large scale systems constructed composition thousands distributed services interacting directly physical world via sensors actuators compose internet things future internet enable realization smart cities vision urban infrastructure used fullest extent offer better quality life citizens key efficient effective realization smart cities scientific technological research covering multiple layers make internet paper discusses research challenges initiatives related future internet smart cities scope interscity project challenges initiatives organized three fronts networking high performance distributed computing software engineering future internet analysis mathematical modeling future internet smart cities interscity aims developing integrated open source platform containing major building blocks development robust integrated sophisticated applications smart cities future
current therapeutic options major depressive disorder mdd bipolar disorder associated lag onset prolong distress impairment patients antidepressant efficacy often limited currently approved antidepressant medications mdd act primarily monoaminergic mechanisms glutamate major excitatory neurotransmitter central nervous system glutamate cognate receptors implicated pathophysiology mdd development novel therapeutics disorder rapid robust antidepressant effects methyl aspartate nmda antagonist ketamine first observed since nmda receptor antagonists studied mdd demonstrated relatively modest antidepressant effects compared ketamine shown favorable characteristics article reviews clinical evidence supporting use novel glutamate receptor modulators direct affinity cognate receptors non competitive nmda receptor antagonists ketamine memantine dextromethorphan azd subunit glunb specific nmda receptor antagonists traxoprodil nmda receptor glycine site partial agonists glyx metabotropic glutamate receptor mglur modulators azd basimglurant also briefly discuss several theoretical glutamate receptor targets preclinical antidepressant like efficacy yet studied clinically include alpha amino hydroxyl methyl isoxazoleproprionic acid ampa agonists mglur negative allosteric modulators review also discusses promising non glutamatergic targets potential rapid antidepressant effects including cholinergic system scopolamine opioid system alks corticotropin releasing factor crf receptor antagonists others published elsevier ltd
quench fragmentation non explosive process occurs molten magma super cooled glass upon contact ambient water occurs coherent lavas erupted subaqueously flow water magma intrudes water saturated sediments magma water interact explosively phreatomagmatism quench fragmentation also occurs alongside explosive phreatomagmatic activity though products quench fragmentation hyaloclastite sensu stricto discussed qualitatively volcanological literature compared explosive fragmentation processes little known exact dynamics quench fragmentation magma relates rheology physical properties volcanic glass based literature materials engineering present detailed review processes glass forms properties glass fracture mechanics cause fragment non explosively also consider applied understanding dynamics behind volcanological processes situ glass fragmentation quenching wet environments phreatomagmatism important parameters occurrence quench fragmentation temperature difference magma ambient water much ambient water superheated leidenfrost temperature geometry lava magma intrusion thermal conductivity thermal expansion also great importance resistance magma fragmentation increased presence crystals provided thermal expansion crystals greatly exceed glass vesicles opposite effect unless magma highly vesicular overview provides solid basis quantitative study quench fragmentation hyaloclastite formation elsevier rights reserved
surface plasmons electrical charge oscilllations excited metal surface light provide means optical energy converted electrical energy manipulated nanoscale surface plasmons propagate waves waveguide devices exists localised resonances metal nanoparticles plasmonic circuits developed mimic waveguide based optical circuit devices plasmons metal nanoparticles likened excitations electrical circuits although surface plasmons electrical nature preserve phase coherence incident optical fields excite regard surface plasmon devices represent convergence optics electronics paper review work two fields discuss progress towards devices nanoscale control optical signals optical signal processing
paper presents realization fuzzy logic controller concepts using operational amplifiers tool teach students design modeling design flc performed path provides good background student experience complete process approach goes verbal description problem throughout final practical implementation passing process mathematical modeling understanding realization function means basic blocks consist operational amplifier circuits taught first circuit course pushing application little beyond still within reach already acquired background
numerous reasons leading change software changing requirements changing technology increasing customer demands fixing defects etc thus identifying analyzing change prone classes software software evolution gaining wide importance field software engineering would help software developers judiciously allocate resources used testing maintenance software metrics used constructing various classification models used timely identification change prone classes search based algorithms form subset machine learning algorithms utilized constructing prediction models identify change prone classes software search based algorithms use fitness function find best optimal solution among possible solutions work analyze effectiveness hybridized search based algorithms change prediction words aim work find whether search based algorithms capable accurate model construction predict change prone classes also constructed models using machine learning techniques compared performance models models constructed using search based algorithms validation carried two open source apache projects rave commons math results prove effectiveness hybridized search based algorithms predicting change prone classes software thus utilized software developers produce efficient better developed software elsevier ltd rights reserved
propose new controller converters based particle swarm optimization pso new converter controller uses pso optimization method directly control output voltage boost converter order validate qualify proposed converter controller analyzed implemented variants pso algorithm namely standard pso global local best pso proposed converter controller compared variant classic controller anti windup different operational conditions three controllers compared work implemented microcontroller tmsf using code composer studio texas instruments results show proposed controller exhibits better behavior terms settling time overshoot unlike popular converter controllers proposed controller require sort optimal parameter determination elsevier rights reserved
core aspect work review player detection tracing coaches players prepare widely studying opponents attacking self protecting formations plays metrics every game moving object detection one serious problems field surveillance traffic monitoring computer vision player tracking sports video forth detecting objects video tracking movement recognise qualities demanding examination zone area computer image image processing core aspect work review player detection tracking coaches players prepare widely studying opponents offensive defensive formations plays metrics every game tracking player becomes major problem different problems appearance occlusion work offers analysis detection objects segmentation objects tracking objects also provides study comparison diverse methods used player tracking
study investigated whether self compassion emotional invalidation perceiving others indifferent one emotions may explain relationship childhood exposure adverse parenting adult psychopathology psychiatric outpatients path analysis used investigate associations exposure adverse parenting abuse indifference self compassion emotional invalidation mental health controlling gender age self compassion strongly inversely associated emotional invalidation suggesting schema others unsympathetic indifferent toward one emotions may affect self compassion vice versa self compassion emotional invalidation mediated relationship parental indifference mental health outcomes preliminary findings suggest potential utility self compassion emotional schemas transdiagnostic treatment targets elsevier ireland ltd rights reserved
use zeotropic fluid mixtures refrigeration cycles heat pumps widely studied last three decades however past years use zeotropic mixtures power generation applications analysed large number studies mostly low grade heat energy source paper presents review recent research power cycles zeotropic mixtures working fluid available literature primarily discusses thermodynamic performance mixture power cycles energy exergy analyses studies also consider economic aspects investigation capital investment costs thermoeconomic analysis reviewed literature paper divided based various applications solar energy based power systems geothermal heat based power systems waste heat recovery power systems generic studies fluid mixtures used various studies listed along key operation parameters scale power plant order limit scope review studies system level analysis various power cycles considered overview key trends general conclusions various studies possible directions future research also presented elsevier ltd rights reserved
paper presents general frequency domain framework predicting multimode coupled buffeting response long span bridges nonstationary winds within framework wind speed field aerodynamic forces bridge response separated deterministic time varying mean evolutionary random fluctuating components assumption low variation rate mean wind speed time varying mean self excited buffeting forces modeled static force coefficients flutter derivatives admittance functions determined wind tunnel stationary wind consideration nonstationary wind characteristics quasi steady manner time varying mean bridge response calculated static analysis time instant random buffeting response expressed generalized modal displacements governed equations frequency dependent linear time variant ltv system equivalent frequency independent ltv system introduced permits calculation response impulse functions directly system modal properties frozen time formulations presented calculating time varying rms value evolutionary spectrum bridge response extreme value distribution traditional buffeting analysis framework stationary wind excitations special case general framework based analysis framework buffeting responses long span suspension bridge center span approximately various nonstationary winds investigated shed insights general characteristics nonstationary wind load effects long span bridges effectiveness accuracy framework also confirmed time domain monte carlo simulations american society civil engineers
embryonic development homeothermic animals like birds mammals transition ectothermy endothermy occurs especially precocial species taxa based evolutionary aspects development endothermy review focuses prenatal development endothermy thermoregulatory system using precocial bird model final incubation precocial bird embryos prerequisites respond environmental temperature influences nearly appropriate way autonomic neuronal molecular mechanisms underlying development endothermy established transition thermoregulatory system control system without feedback system feedback mechanisms occurs precocial bird embryos endothermic homeothermic incubation temperature decreases normal level seems associated summit metabolism increased incubation temperatures embryos able stabilize body temperature therefore normal temperatures homoeothermy occur limited temperature range elsevier rights reserved
paper presents dual band digitally controlled oscillator dco based ring oscillators topology differential input output ghz proposed circuit two frequency band switches digital mode bit switching two bands dco change delay path power consumption run time new source coupled logic scl based reconfigurable delay element schmitt trigger characteristic used stage bits digital code control current tails power consumption profile frequency band steady regime proposed designs fully differential appropriate low jitter high performance applications proposed dco simulated spice cmos standard supply frequency power consumption jitter lower band mhz mhz mhz mhz upper band mhz mhz ghz mhz sequentially paper also circuit analysis proposed dco delay calculation comparison analytical equation frequency bands obtained also monte carlo pvt test shows acceptable frequency tolerance
awareness energy efficiency buildings increasingly expands algeria legal framework exists promoting utilization regenerative energies however models best practice still relatively contribution paper reports study aims finding best design strategies affordable energy efficient residential buildings focus put mediterranean algiers saharan ghardaia dynamic energy modelling carried using trnsys assess residential house built med enec pilot project simulation executed two sequential stages reconnaissance stage building compared typically non insulated conventional construction assessment stage pilot project already designed low energy standards investigated attempt increase energy efficiency means parametric study efficient passive design measures minimizing heating cooling energy demands delineated dimensioning fixed results confirm easiness save energy comparison local inappropriate conventional building type possible additional energy savings pilot project almost heating required cooling visibly reduced elsevier ltd rights reserved
paper presents new experimental setup aerodynamic section model testing bridge decks rig designed move section model arbitrary motion wind tunnel imitate motions scaled real bridge motion step motion random motion histories close white noise proposed setup enables forces acting section model measured directly considering motions resemble actual bridge motion still fully utilizing benefits forced vibration testing technique excellent performance system testing procedure proved performing state art forced vibration tests extract flutter derivatives hardanger bridge cross section new experimental setup used simulate three degree freedom dynamic system driven white noise investigate whether estimates aerodynamic derivatives sensitive motion considered experimental results demonstrate estimates aerodynamic derivatives sensitive motion considered results indicate principle superposition fully applicable cross section long motions within range considered
purpose study circulation retinal vessels patients blood dyscrasia due myeloproliferative neoplasms using non invasive retinal imaging methods prospective consecutive case series seven treatment naive patients chronic myeloid leukaemia polycythemia vera essential thrombocytosis examined cytoreductive treatment investigated retinal circulation motion contrast imaging retinal oximetry spectral domain optical coherence tomography results retinal venous blood velocity increased retinal arterial oxygen saturation increased follow mean weeks range weeks complete haematological remission achieved cytoreductive treatment abnormal optical coherence tomography reflectivity patterns present baseline patients chronic myeloid leukaemia replaced normal patterns follow retinopathy form cotton wool spots retinal haemorrhages found presentation two patients chronic myeloid leukaemia one patient polycythemia vera retinopathy resolved follow patients conclusion non invasive retinal imaging able demonstrate increased retinal venous blood velocity increased retinal arterial blood oxygenation normalization intravascular reflectivity patterns successful treatment myeloproliferative neoplasms larger prospective studies needed assess prognostic value non invasive imaging methods predicting circulatory complications myeloproliferative neoplasms
economic societal costs urban heat island considered marginal effect temperature increase device efficiency lifespan urbanization virtually synonymous mechanization human comfort systems efficiency systems subject degradation urban heat island simplest way model degradation application ideal device efficiencies results analysis presented considered paper magnitude costs avoidance potential mitigation avenues principal topics work technical underpinnings approach presented supplementary material available online self reinforcing nature economic scale urban heat island effect thus approached first principles thermodynamics available data relevant devices systems global perspective phenomenon presented followed case study phoenix arizona metropolitan area demonstrate scale effects analysis synthesizes thermodynamic economic approaches health policy issues urban heat island particular consideration given planning minimization effects low middle income urban areas study first estimates costs borne today large urban centres highlights risks secondary cities eventually face could potentially mitigate undergo rapid growth densification
abnormal operating conditions timing belt lead cracks fatigue sudden rupture damage engines study intelligent system developed detect classify high load operating conditions high temperature operating conditions timing belts achieve vibration signals normal operating conditions high load operating conditions high temperature operating conditions collected time domain signals transformed frequency domain time frequency domain using fast fourier transform method wavelet transform method respectively data mining stage statistical features extracted different signal domains improved distance evaluation method adopted select best features reduce input space classifier signal features time domain frequency domain time frequency domain fed artificial neural network evaluate accuracy designed procedure detecting inappropriate operating conditions timing belt based features extracted signals time frequency time frequency domains artificial neural network classifier detected classified normal operating conditions high load operating conditions high temperature operating conditions accuracies respectively classification accuracies using features selected improved distance evaluation signals time frequency time frequency domains found respectively results showed developed system capable detecting classifying normal operating conditions abnormal operating conditions timing belt results also suggested combination signal processing feature selection significantly enhance classification accuracy
offenders antisocial personality disorder aspd may characterized lack emotional functioning manifests irritability lack remorse proposed link aspd negative emotionality led question emotional processing anomalies aspd furthermore effect childhood maltreatment abuse emotional processing tested present study violent sexual offenders aspd without aspd healthy non criminal controls compared emotional stroop task est using neutral negative violence related words secondary analyses focused effect psychopathic traits childhood maltreatment offenders aspd showed stronger attentional bias violence related negative words compared controls comparable results obtained grouping offenders high medium low psychopathic subgroups offenders childhood maltreatment specifically showed stronger violence related attentional bias non maltreated offenders data suggest enhanced attention violence related stimuli adult criminal offenders associated adverse developmental experiences delinquency lesser extent antisocial psychopathic traits elsevier ireland ltd rights reserved
background abnormal epithelial mesenchymal restorative capacity idiopathic pulmonary fibrosis ipf recently associated accelerated aging process key point altered wound healing advanced glycation end products ages consequence non enzymatic reactions lipid protein several oxidants aging process receptor ages rages implicated lung fibrotic process alveolar homeostasis however age rage aging pathway explored ipf methods lung samples ipf control patients obtained surgical lung biopsy differences ages rage expression groups evaluated pcr western blot immunohistochemistry effect ages cell viability primary lung fibrotic fibroblasts alveolar epithelial cells assessed cell transformation fibrotic fibroblasts cultured glycated matrices evaluated different experimental conditions results study demonstrates increase ages together decrease rages ipf lungs compared control samples two specific ages involved aging pentosidine carboxymethyl lysine significantly increased ipf samples immunohistochemistry identified higher staining ages related extracellular matrix ecm proteins apical surface alveolar epithelial cells aecs surrounding fibroblast foci fibrotic lungs hand rage location present cell membrane aecs control lungs almost missing pulmonary fibrotic tissue addition vitro cultures showed effect ages cell viability different aecs fibrotic fibroblasts ages decreased cell viability aecs even low concentration fibroblast viability less affected furthermore fibroblast myofibroblast transformation could enhanced ecm glycation conclusions findings suggest possible role increased ratio ages rages ipf could relevant accelerating aging tissue reaction abnormal wound healing lung fibrotic process
well known paper akerlof yellen katz proposed counter intuitive explanation rise non marital births united states emphasized birth control abortion weakened responsibility men unmarried partner pregnancy paper regularly cited social conservatives support measures restrict sex education access contraception abortion argue use paper findings stems specific modeling assumptions types women present reformulation model using reasonable types generates precisely results radically different policy implications
mdsplus data acquisition analysis system used worldwide predominantly fusion research community development began years ago openvms operating system since time many new features added code ported many different operating systems contributions mdsplus development fusion community way feature suggestions feature implementations documentation porting different operating systems bulk development support mdsplus however provided relatively small core developer group three four members given size development team large number users much effort focused providing new features community keeping underlying code documentation date evolving software development standards ensure mdsplus continue provide needs community future mdsplus development team along members mdsplus user community commenced major quality improvement project planned improvements include changes software build scripts better use gnu autoconf automake tools refactoring many source code modules using new language features available modern compilers using gnu mingw create windows distributions migrating modern source code management system improvement source documentation well improvements www mdsplus org web site documentation layout addition comprehensive test suites apply mdsplus code builds prior releasing installation kits community work lead much robust product establish framework maintain stability enhancements features added paper describe efforts either progress planned near future elsevier rights reserved
anthracnose considered important postharvest disease papaya hydrothermal treatment calcium chloride shown effective inhibit anthracnose objective study investigate effect combination development anthracnose papaya fruit inoculated colletotrichum gloeosporioides immersion spore suspension divided two groups one received treatment degrees min combined min used control afterwards fruit stored days degrees allow development fungal infection anthracnose incidence severity estimated visually development disease analyzed light electron microscopy reduced anthracnose incidence severity compared control microscopy analysis showed melted epicuticular wax covered stomata resulted lower mycelial growth fruit respect control samples also induced formation round shaped vesicles corresponded greater accumulation total phenolics observed treated fruit effective delay symptoms anthracnose days storage papaya degrees elsevier rights reserved
seasonal affective disorder subtype affective disorders studied treatment light therapy although second generation antidepressants also option grief reactions normal patients experiencing loss primary care providers pcps aware expected course grief severe symptoms indicate complex grief adjustment disorder time limited abnormal response stressor pcps manage patients adjustment disorder arranging counseling screening suicidality assessing substance abuse ruling psychiatric diagnoses present reliable data suggest medication management
supraglacial rivers greenland ice sheet gris transport large volumes surface meltwater toward ocean yet received relatively little direct research study presents field observations channel width depth velocity water surface slope nine supraglacial channels south western gris collected july august field sites located inland span elevation contain measured discharges larger previous situ study channels wide channels deeply incised near vertical banks hydraulic geometry results indicate supraglacial channels primarily accommodate greater discharges increasing velocity smaller streams steeper water surface slopes typical terrestrial settings yielding correspondingly high velocities froude numbers supercritical flow observed measurements derived manning values larger variable anticipated channels uniform substrate ranging mean value despite absence sediment debris roughness elements ubiquitous micro depressions shallow sections channel bed may explain roughness values however find unobserved sources flow resistance likely contributed elevated manning values future work explicitly consider additional sources flow resistance beyond bed roughness supraglacial channels conclude hydraulic modeling channels must allow subcritical supercritical flow importantly must refrain assuming ice substrate channels exhibit similar hydraulic behavior especially froude numbers manning finally study highlights theoretical empirical work supraglacial channel hydraulics necessary broad scale understanding ice sheet hydrology achieved copyright john wiley sons ltd
space moving object recognition tracking important research topic computer vision broad application prospects space exploration detection traffic flow military field automatic control fields paper aims propose new space target recognition algorithm use algorithm identify motion trajectory simulation certain object universe
background objectives mixed results obtained regarding memory patients borderline personality disorder bpd prior reports anecdotal evidence suggests patients bpd prone false memories assumption put firm empirical test yet methods memory accuracy confidence assessed bpd patients healthy controls using visual variant false memory deese roediger mcdermott paradigm involved negative positive valenced picture results groups differ regarding veridical item recognition importantly patients display false memories controls trend level borderline patients rated items new high confidence compared healthy controls conclusions results tentatively suggest borderline patients show uncompromised visual memory functions display increased susceptibility distorted memories elsevier ltd rights reserved
prevalence type diabetes continues escalate health system reform seeking better patient outcomes new models care aim provide appropriate care needed patients experiences service innovations shed light successes challenges implementing change paper explores patients views new model integrated care patients type diabetes mixed methods randomised control trial evaluated beacon clinic model care complex type diabetes led specialist general practitioners gps primary care settings brisbane australia qualitative sub study conducted may january consenting participants interviewed months using semi structured questions explore experiences new model care interview transcripts analysed thematically first theme organised patient centred care patients appraised structural elements clinic enabling experience included convenience flexibility prompt communication back referring gps preferences minority partly realised tried understand clinical purpose comparison traditional care second theme positioned partners care revealed pivotal role patient clinician relationships patients engagement advice self care found clinicians collaborative approach engaging motivating small minority contextual concerns disappointed focus diabetes struggled engage fully model participants valued model care reflects capacity manage variable complex needs patients referred care however multi level strategies also needed enhance patients engagement care sustainability integrated diabetes care
objectiveto investigate effects light therapy serotonin transporter binding htt bpnd index htt levels anterior cingulate prefrontal cortices acc pfc healthy individuals fall winter twenty five per cent healthy individuals experience seasonal mood changes affect functioning htt bpnd found higher across multiple brain regions fall winter relative spring summer elevated htt bpnd may lead extracellular serotonin loss low mood hypothesized fall winter light therapy would reduce htt bpnd acc pfc sample brain regions involved mood regulation methodin single blind placebo controlled counterbalanced crossover design dasb positron emission tomography used measure htt bpnd following light therapy placebo conditions fall winter resultsin winter light therapy significantly decreased htt bpnd acc relative placebo fall significant change htt bpnd found region across conditions conclusionthese results identify first time central biomarker associated intervention light therapy humans may applied develop treatment prevention seasonal depression
morphological matrix method key legal point view main function program portfolio analysis combination good program list due combination lot number programs therefore difficult compare one one evaluation difficult get best program main problem lies expert system knowledge acquisition reasoning difficult intelligent design car mechanical system actually instance reasoning matching process paper automotive intelligent design system based cbr rbr attempt improve efficiency product design icad system technology artificial intelligence expert system optimization design finite element analysis computer graphics various numerical calculation methods combine respective merits complement aim make computer much possible participate decision making structural design performance analysis graphics whole process
ethnopharmacological relevance ubtan traditional herbal formulation indian system medicine used india subcontinent long time several commercial skin care formulations marketed throughout region name ubtan therefore worthwhile evaluate ubtan respect efficacy skin care formulation aim study present study designed preparation ubtan standardization chromatographic techniques using suitable phyto markers antioxidant sun protection factor spf anti tyrosinase potential explored materials methods four house formulations prepared mixing varied quantity powdered plants turmeric curcuma longa chickpea cicer arietinum sandalwood santalum album optimization formulations made evaluating biological activity vitro assay evaluation physicochemical properties optimized formulation carried analysis flow properties stability moreover rphplc reverse phase high performance liquid chromatography hptlc high performance thin layer chromatography standardization performed quantitative qualitative analysis results ubtan formulations ito showed free radical scavenging ferric reducing potential may due high phenolic flavonoid content statistically significant pearson correlation confirmed positive correlation phenolic content spf formulations tyrosinase inhibition study indicated formulations showed diphenolase monophenolase inhibitory activity among four formulations showed notable biological activity content curcumin ascorbic acid found respectively hplc estimation physiochemical properties exhibited good flow rate aqueous solubility stability studies anticipated stable longer periods microbial load count heavy metal content lead arsenic mercury cadmium formulation also within permissible limit pharmacopeial standard conclusion scientific exploration helps set quality safety standard traditional cosmetic formulation ubtan use herbal skin care product elsevier ireland ltd rights reserved
background childhood cancer survivors high burden chronic conditions related cancer treatment debilitating potentially life threatening much remains learned late effects bone soft tissue sarcoma survivors procedures utah cancer registry used identify survivors bone soft tissue sarcomas diagnosed ages years alive least years diagnosis selected age sex matched comparison cohort hospitalizations extracted utah department health statewide inpatient hospitalization discharge records cox poisson gamma regressions used evaluate risk hospitalization rate admission length stay survivors versus comparison cohort primary icd codes defined common reasons hospitalizations results hazard ratio hospitalization higher survivors reference comparison cohort confidence interval survivors experienced hospital admissions rate ratio longer length stay compared comparison cohort survivors treated chemotherapy three fold higher risk hospitalization compared survivors received surgery radiation alone among hospitalized survivors common reason injury bone tumor neoplasm soft tissue sarcoma conclusion childhood survivors bone tumor soft tissue sarcoma face ongoing risk hospitalization years diagnosis
background robotic training commonly used assist walking training patients affected multiple sclerosis non conclusive results objective compare effect robot assisted gait training ragt conventional walking training cwt gait competencies global ability fatigue spasticity group severely affected patients methods pilot single blind randomized controlled trial conducted severe expanded disability status scale edss score non autonomous ambulant patients experimental group performed sessions ragt whereas control group performed amount cwt primary outcome measures gait ability assessed minutes walking test functional ambulatory category secondary outcomes global ability modified barthel index global mobility rivermead mobility index severity disease edss subjectively perceived fatigue fatigue severity scale results number subjects achieved clinical significant improvement significantly higher ragt cwt primary outcome measures ragt also led improvement clinical parameters global ability global mobility edss fatigue conclusions ragt improved walking competencies non autonomous ambulant patients benefits terms perceived fatigue
ihome monitoring system aims help caregivers take care elderly main module hope system provides intelligent ambient environment employing prediction based elderly daily activity monitor goal ihome non invasively monitor elderly behavior pattern notify caregiver upon abnormality detection fall detection movement pattern enhances safety elderly could live independently technology behind includes arduino based ambient sensors tracking based sensors case based reasoning prediction algorithm pebble wearable application
original analog function synthesizer circuit increased accuracy presented allowing implement multitude important continuous mathematical functions accuracy proposed structure excellent range input variable strongly extended result third order approximation implemented functions circuit performance expected stable process corners functions exclusively depend current ratios great advantages increased modularity controllability associated reduced design costs per function represent immediate consequence multiple functions realized proposed structure function synthesizer circuit designed implementing cmos technology supplied spice simulations confirm estimated theoretical results showing approximating error smaller composing squaring block smaller composing multiplier divider block
follow studies disease event time subject left truncation right censoring furthermore medical advancements made possible patients cured certain types diseases article consider semiparametric mixture cure model regression analysis left truncated right censored data model combines logistic regression probability event occurrence class transformation models time occurrence investigate two techniques estimating model parameters first approach based martingale estimating equations ees second approach based conditional likelihood function given truncation variables asymptotic properties proposed estimators established simulation studies indicate conditional maximum likelihood estimator cmle performs well estimator based ees unstable even though shown consistent special intriguing phenomenon approach cure model provide insights issue find approach improved significantly assigning appropriate weights censored observations ees finding useful overcoming instability approach complicated situations likelihood approach feasible illustrate proposed estimation procedures analyzing age onset occiput wall distance event patients ankylosing spondylitis
male hypogonadism increasing prevalence particularly older male population signs symptoms associated hypogonadism often nonspecific may difficult categorize article discusses parameters screening patients risk reviews establish diagnosis primary secondary male hypogonadism offers important considerations treatment patients hypogonadism
article performance two analytical methods known homotopy perturbation method hpm adomian decomposition method adm solving linear nonlinear boundary value problems structural engineering fluid mechanics compared order compare mathematical models various problems inelastic viscoelastic flows deformation beams plate deflection theory chosen addition results two methods compared exact solutions evaluate precision accuracy numerical methods
duration load dol effect combined influence mechanical loading history climatic history strength materials dol effect one important characteristics wood wood based materials material degradation damage induces strength reductions creep one important effects dol creep phenomenon negatively affects functional compliance behavior strength timber structures extended years exploitation creep phenomenon affected surrounding temperature relative humidity timber moisture content factors study aimed establish correct factor system accurate prediction long term deformations timber structures corresponding environmental conditions timber properties region latvia experimental research made jelgava latvia represents timber beam four point long term loading bending variable cross section height span length ratio uncontrolled climatic conditions timber beams two different span lengths used timber beam cross section dimensions height width timber beams dried moisture content start experiment varied applied load values moisture content fluctuations negative air temperature accelerated creep development intensity prediction final long term deformations rate type timber material service class strength class
primary care critical setting screening management pediatric sleep difficulties review summarizes studies examining prevalence sleep problems primary care settings well current practices screening diagnosis management including behavioral recommendations medications potential barriers effectively addressing sleep also reviewed despite high prevalence pediatric sleep problems primary care rates screening management low primary care providers receive minimal sleep training resulting gaps knowledge confidence parents similarly gaps knowledge many factors contribute identification sleep problematic recommendations improve provision sleep services pediatric primary care made areas research practice education elsevier ltd rights reserved
paper present virtual touch toolkit allows development educational activities mixed reality environment using various tangible elements interconnection virtual world real world enabled main goal virtual touch facilitate installation configuration programming different types technologies abstracting creator educational applications technical details involving use tangible interfaces virtual worlds therefore specially designed enable teachers create educational activities students simple way taking account teachers generally lack advanced knowledge computer programming electronics toolkit used develop various educational applications tested two secondary education high schools spain
certain messages even directly payoff relevant credible form communication light natural social preferences social image concerns regarding preferences interact create incentives communicate one feels people recognizing prevalence incentive communicate one social preferences suggests many social economic phenomena norms etiquette cooperation gift exchange seen part forms signaling behaviors may surprisingly robust material costs yet sensitive context
stressors early life induce anxiety depressive like responses adult rodents siberian hamsters phodopus sungorus exposed short days post weaning also increase adult anxiety depressive like behaviors test hypothesis melatonin exposure stressors early life interact alter adult affective responses administered melatonin either perinatal gestational day postnatal day postnatal day periods also exposed subset dams restraint gestation day days final week injections depressive like behaviors assessed using sucrose anhedonia forced swim tests hamsters exposed prenatal restraint treated melatonin postnatal period increased depressive like responses forced swim test relative groups offspring restrained dams increased number fecal boli produced forced swim test anxiety like response present study prenatal restraint reduced dendritic branching overall perinatal melatonin protected hamsters restraint induced reduction results suggest photoperiodic conditions coincident birth early life stressors important development adult affective responses elsevier rights reserved
although infliximab approved psoriasis efficacy reduced time patients aim phase iii trial evaluate efficacy safety infliximab dose escalation japanese psoriasis patients loss efficacy standard dose therapy patients plaque psoriasis psoriatic arthritis pustular psoriasis psoriatic erythroderma showed loss efficacy standard dose therapy received infliximab dose escalation every weeks weeks loss efficacy defined maintaining reduction psoriasis area severity index pasi achieving pasi efficacy safety evaluated week fifty one patients received dose escalation completed study pasi median improvement rate pasi score week respectively showing efficacy skin symptoms efficacies quality life nail psoriasis joint pain also obtained median serum infliximab level increased less weeks showing positive correlation efficacy serum infliximab level week favorable efficacy observed patients detectable serum infliximab levels baseline incidences adverse events serious adverse events serious infections serious infusion reactions respectively marked difference observed efficacy safety among psoriasis types new safety concerns observed infliximab dose escalation effective well tolerated psoriasis patients loss efficacy standard dose therapy suggesting dose escalation may useful therapeutic option patients
migration key cellular function important implications cell physiology impairment function observed angiogenesis cancer central nervous system development many physiological pathological events serum considered among potent physiological chemotactic stimuli transglutaminase involved mentioned processes suggesting hypothesis may modulate cell movement chemotaxis acting serum factors cell biology biochemistry studies confirmed hypothesis showing human serum contains potent chemotactic signals significantly impaired activated bioinformatics studies indicated one potent serum factor potential substrate dependent transamidation platelet derived growth factor pdgf cell biology immunometric experiments carried umg human glioma cell line showed human recombinant pdgf pre incubated calcium activated lost chemotactic activity antigenicity data indicate pdgf substrate transamidating activity modification may play key role modulation pdgf chemotactic features findings suggest novel point view study extracellular functions understand protein signals growth factors cytokines act extracellular space reach specific targets
detection processing novel information encountered environment crucial proper adaptive behavior learning hippocampus prime structure novelty detection receives high level inputs including context information interest understand mechanisms hippocampus processes contextual information performed vivo microdyalisis order monitor extracellular changes neurotransmitter levels object location memory olm behavioral protocol developed evaluate contextual information processing recognition memory neurotransmitter release evaluated dorsal hippocampus insular cortex olm month old bsf mice found simultaneous release dopamine norepinephrine hippocampus olm neurochemical activity remained unaltered cortex additionally administered hydroxy dopamine ohda neurotoxic compound selective dopaminergic noradrenergic neurons dorsal hippocampus different group mice depletion catecholaminergic terminals hippocampus ohda impaired olm affect novel object recognition results support relevance hippocampal catecholaminergic neurotransmission recognition memory significance catecholaminergic function may extended clinical field reported innervation hippocampus noradrenergic dopaminergic system reduced atrophied aging alzheimer disease brain wiley periodicals inc
dipeptidyl peptidase dpp promising type diabetes mellitus tdm drug target dpp inhibitors prolong action glucagon like peptide glp gastric inhibitory peptide gip improve glucose homeostasis without weight gain edema hypoglycemia however marketed dpp inhibitors adverse effects nasopharyngitis headache nausea hypersensitivity skin reactions pancreatitis therefore still expected novel dpp inhibitors minimal adverse effects scaffolds existing dpp inhibitors structurally diversified makes difficult build virtual screening models based upon known dpp inhibitor libraries using conventional qsar approaches paper report new strategy predict dpp inhibitors machine learning approaches involving naive bayesian recursive partitioning methods built machine learning models based known dpp inhibitors optimized molecular properties topological fingerprints descriptors overall predictive accuracies optimized models greater external test set composed recently reported compounds employed validate optimized models results demonstrated models good predictive ability based different combinations descriptors twenty good twenty bad structural fragments dpp inhibitors also derived models inspiring new dpp inhibitor scaffold design
important characteristic semi supervised learning methods combination available unlabeled data along enough smaller set labeled examples increase learning accuracy compared default procedure supervised methods hand use labeled data training phase work implemented hybrid self trained system combines support vector machine decision tree lazy learner bayesian algorithm using stacking variant methodology performed depth comparison well known semi supervised classification methods standard benchmark datasets finally reached point presented technique better accuracy cases
background purposecerebral atrophy suggested reliable magnetic resonance imaging mri predictor subsequent disability stages multiple sclerosis however accepted methodology routine clinical use exists date sought easy apply fast technique evaluate cerebral ventricular volume patients similar accuracy semiautomatic volumetric method methodsthe study included patients diagnosed clinically isolated syndrome addition healthy controls enrolled physical disability assessed expanded disability status scale cognitive disability multiple sclerosis inventory cognition music test subjects received standardized dimensional imaging scanner third ventricle volume obtained weighted images using semiautomated technique compared planimetric assessment width third ventricle aligned avw unaligned uvw anatomical landmarks resultsavw obtained within seconds excellent intra interrater agreement outperformed volumetric measurements regarding differentiation patients healthy controls avw strongest correlations showed moderate inverse correlation music cognition score conclusionsavw time effective robust biomarker strong correlations volumetric measurements established standard mri quantification central brain atrophy patients early
aim present study prospective analysis neuromonitoring somatosensory evoked potentials ssep transcranial motor evoked potentials tcmep consecutive scoliosis surgeries done tertiary care spine centre materials methods prospective analysis performed consecutive patients undergoing scoliosis correction sseps obtained stimulating median tibial nerves stimulus intensity level tcmeps recorded bilaterally abductor pollicis brevis biceps deltoid upper limb tibialis anterior quadriceps gastrocnemius abductor hallucis lower limb stimulation given form high voltage stimulus alert defined reduction amplitude least ssep least tcmep compared baseline recordings increase latency results mean age patients years years thirty nine patients females males baseline values neuromuscular scoliosis low compared adolescent idiopathic scoliosis ais false negative incidents false positive cases due low blood pressure malfunctioning leads conclusion use upper limb leads could help identifying malposition malfunctioning leads eliminate false positive results combined multimodal intraoperative monitoring helps increasing safety scoliosis corrective surgeries high sensitivity specificity baseline values neuromuscular scoliosis patients possibly lower idiopathic scoliosis patients intraoperative variations must interpreted caution
objective examine respective contributions changes visceral adiposity subcutaneous adiposity liver fat cardiorespiratory fitness crf improvements cardiometabolic risk markers response healthy eating physical activity lifestyle intervention ninety four viscerally obese healthy men completed lifestyle intervention body weight body composition fat distribution assessed anthropometry dexa computed tomography crf adipokines lipoprotein lipid profile oral glucose tolerance assessed crf visceral subcutaneous adiposity significantly improved intervention nadir year partial regain year liver fat estimated insulin hepatic extraction stabilized year year whereas homa isi matsuda index adiponectin continued improve multivariate analysis revealed visceral adiposity estimated liver fat reductions contributed improved isi matsuda index observed three year changes fat mass crf independently associated changes visceral fat adjusted whereas changes crf associated changes estimated liver fat adjusted long term healthy eating physical activity intervention men improves several cardiometabolic risk markers long term despite partial body weight regain observed year year improvement crf contributes visceral estimated liver fat losses long term turn explain benefits lifestyle intervention cardiometabolic risk profile
hydroxyproyl cellulose graft poly isopropylacryamide hpc pnipam copolymers synthesized single electron transfer living radical polymerization set lrp water thf mixture solvent characterized controllability polymerization rate set lrp adjusted water thf ratio mixture solvent monomer conversion rate relatively low solvent low water content thermal responsive property hpc pnipam copolymers aqueous solution depends length graft chains relatively short pnipam side chains repeat units effectively regulate low critical solution temperature lcst hpc pnipam copolymers aqueous solution due hydrophilic properties short pnipam chains work provides approach regulation lcst body temperature region graft copolymerization elsevier ltd rights reserved
order facilitate interaction computermediated communication enrich user experience general introduce novel textual emotion visualization approach grounded generative art evocative visuals approach centered idea affective computer systems able relate communicate evoke human emotions maps emotions identified text evocative abstract animation examined two visualizations based approach two common textual emotion visualization techniques chat emoticons avatars along three dimensions emotion communication emotion evocation overall user enjoyment study organized repeated measures within subject experiment demonstrated terms emotion communication visualizations comparable emoticons avatars however main visualization based abstract color motion shape proved best evoking emotions addition terms overall user enjoyment gave results comparable emoticons better avatars
face sketch photo synthesis technique attracted growing attention many computer vision applications law enforcement digital entertainment existing methods either simply perform face sketch photo synthesis holistic image divide face image regular rectangular patches ignoring inherent structure face image view situations paper presents novel superpixel based face sketch photo synthesis method estimating face structures image segmentation proposed method face images first segmented superpixels dilated enhance compatibility neighboring superpixels input face image induces specific graphical structure modeled markov networks employ two stage synthesis process learn face structures markov networks constructed two scales dilation respectively experiments several public databases demonstrate proposed face sketch photo synthesis method achieves superior performance compared state art methods
present random forest classification regression technique predict intraoperatively unified parkinson disease rating scale updrs improvement deep brain stimulation dbs hypothesized data informed combination features extracted intraoperative microelectrode recordings mers predict motor improvement parkinson disease patients undergoing dbs surgery modified employed rfs account unbalanced datasets multiple observations per patient showed first time five neurophysiologically interpretable mer signal features sufficient predicting updrs improvement finding suggests subthalamic nucleus stn electrophysiological signal characteristics strongly correlated extent motor behavior improvement observed stn dbs
botanical estrogen dietary supplements consumed women substitutes loss endogenous estrogens menopause examine roles estrogen receptor alpha alpha aryl hydrocarbon receptor ahr crosstalk actions bes studied gene regulation proliferation responses four widely used bes genistein daidzein equol soy liquiritigen licorice root breast cancer liver cells bes estradiol acting era stimulated proliferation era chromatin binding target gene expression bes acting ahr bound xenobiotic response element containing chromatin sites enhanced ahr target gene expression cypa cypb tcdd acted quite selectively respective receptors bes acted via receptors ahr activity moderated negative crosstalk ella alpha ahr considered mediators biology pharmacology bes elsevier ireland ltd rights reserved
combination reverse transcription deep sequencing emerged powerful instrument detection rna modifications field seen recent surge activity importance gene regulation recent studies yielded high resolution signatures modified ribonucleotides relying sequence dependent mismatch patterns reverse transcription arrests common alignment viewers lack specialized functionality filtering tailored visualization image export differential analysis consequently community profit platform seamlessly connecting detailed visual inspection signatures automated screening modification candidates coverageanalyzer developed response demand powerful inspection tool freely available three main operating systems sam file format standard input intuitive user friendly tool generally applicable large community biomedical users starting simple visualization rna sequencing rna seq data sophisticated modification analysis significance based modification candidate calling
study presents methodology estimation priori parameters widely used kinematic wave approximation unsteady saint venant equations hydrologic flow routing approach based multi dimensional statistical modeling macro scale spatial variability rating curve parameters using set geophysical factors including geomorphology hydro climatology land cover land use conterminous united states main goal study enable prediction ungauged locations regionalization model parameters results highlight importance regional local geophysical factors uniquely defining characteristics stream reach conforming physical theory fluvial hydraulics application estimates demonstrated hydrologic modeling evaluation deterministic forecasting system performed gauged basins events extracted year simulation considering mean concentration time basins study target application flash flood forecasting skill flow routing simulations significantly high peakflow timing peakflow estimation shows consistency indicated large sample verification resulting priori estimates used hydrologic model employs kinematic wave model flow routing furthermore probabilistic estimates kinematic wave parameters enabled based uncertainty information generated multi dimensional statistical modeling importantly methodology presented study enables estimation kinematic wave model parameters anywhere globe thus allowing flood modeling ungauged basins regional global scales elsevier rights reserved
depressive disorders lack objective physiological measurements characterize affected population facilitate study relevant mechanisms melanopsin mediated light signaling pathway may contribute seasonal variation measured non invasively pupillometry prospectively studied changes melanopsin mediated pupillary constriction participants major depressive disorder mdd control across summer winter solstices melanopsin mediated response measured pupil sustained constriction six high intensity blue light stimulus marginally attenuated mdd relative controls participants mdd unexpectedly showed significantly reduced transient pupillary response low intensity red blue light high intensity red blue light sustained pupillary constriction response high intensity blue light pronounced increasing daylight hours strongly related objectively measured versus estimated light exposure melanopsin mediated impairments pupil response may serve biological marker vulnerability depression low light conditions assessment responses light stimuli response low intensity light may useful study neurobiology mdd related mood disorders
production biofuels process requires adjustment multiple parameters performing experiments parameters changed outputs analyzed imperative cost tests limits number reason important design models predict different outputs changing inputs reducing number actual experiments completed response surface methodology rsm one common methods task machine learning algorithms represent interesting alternative present study predictive performance multiple models built problem data compared production bioethanol lignocellulosic materials four machine learning algorithms including two neural networks support vector machine fuzzy system together rsm method analyzed results show reg corbfn method designed authors improves results alternatives elsevier ltd rights reserved
study designed tested novel type solar energy integrated vacuum membrane distillation vmd system seawater desalination actual environmental conditions wuhan china system consists eight parts seawater tank solar collector solar cooker inclined vmd evaporator circulating water vacuum pump heat exchanger fresh water tank brine tank natural seawater used feed hydrophobic hollow fiber membrane module used improve seawater desalination experiment conducted typical summer day results showed highest ambient temperature degrees maximum value average solar intensity system able generate per membrane module distilled fresh water day retention rate electrical conductivity average salt rejection proposed vmd system shows favorable potential application desalination brackish waters high salt wastewater treatment well
physical design data storage critical administrative factor optimizing system performance improved system performance achieved building indices must noted although indices improve system performance creating many random indices may negative impact system performance result wasted space selecting indices properly fundamental aspect system design optimization often complex task index selection optimization techniques widely studied database management system dbmss however get study mapreduce relational databases paper focuses index selection process hadoop database hybrid systems main contribution utilization data mining techniques develop tool determining optimal index set configurations overall evaluation shows index configurations recommended developed tool achieved average performance gain total analytical tasks performed
linear elastic fracture mechanics lefm implies crack like flaws would intensify stress brittle materials stress intensity scaling square root crack size therefore apparent strength materials tends much smaller theoretical value paper examine stress state nacreous composites find materials crack induced stress intensification dependence crack size suppressed greatly feature nacreous composites attributed unique brick mortar structure synergistic match mechanical properties brick minerals mortar proteins phases findings provide fundamental insight origin excellent mechanical properties nacreous composites high strength high toughness flaw tolerance also great value design synthesis new structural materials superior mechanical properties elsevier ltd rights reserved
gambling disorder frequently underdiagnosed disabling disorder prevalence greatly increased recent decades various reasons small part pathological gamblers seek support making difficult early identification delaying administration appropriate treatment dsm disorder reclassified impulse control disorder elsewhere classified one substance related addictive disorders intention improve diagnosis better targeting treatment stimulating research efforts directed disorder article reviews assessment techniques psychosocial neurobiological factors development pathological gambling treatment strategies
objectives postoperative infections still important problem cardiac surgery especially paediatric population may influence final outcome congenital heart disease treatment postoperative infections fungi uncommon aetiology poorly understood proper diagnosis treatment unclear single centre study frequency invasive fungal disease children underwent surgical management congenital heart diseases determined along risk factors infection treatment options outcomes methods consecutive paediatric patients years age underwent cardiac surgery congenital heart disease september december paediatric cardiac centre poland identified developed invasive fungal disease early postoperative period days identified results cardiosurgical procedures congenital heart disease complicated fungal infection one patient high probability fungal infection diagnosis unproved nevertheless patient successfully treated antifungal treatment five proven invasive fungal disease diagnosed candidaemia undergone cardiopulmonary bypass remaining patients preterm newborn complete atrioventricular septal defect developed rib fungal invasion remaining patient pulmonary atresia ventricular septal defect developed fournier gangrene surgery none patients died due infection early postoperative period however child rib fungal invasion died days surgery result multiorgan failure conclusions fungal infections paediatric patients cardiac surgery may markedly influence morbidity mortality fungal infection prophylaxis specific group children may reduce morbidity whereas early empirical treatment followed targeted approach may improve outcomes hit fast hit hard treatment strategy may best rescue option children develop invasive fungal disease cardiac surgery
density hypothesis states positive information similar negative information resulting higher density positive information mental representations present research applies density hypothesis recognition memory explain apparent valence asymmetries recognition memory namely recognition advantage negative information previous research explained negativity advantage basis valence induced affect predicted positive information higher density impairs recognition performance two old new word recognition experiments tested whether differential density positive negative stimuli creates negativity advantage recognition memory valence induced affect experiment participants better discriminated negative word stimuli less false alarms showed response bias towards positive words regression analyses showed asymmetry function density valence experiment varied stimulus density orthogonal valence discriminability response bias function density valence conclude higher density positive information causes apparent valence asymmetry recognition memory
use alzheimer disease biomarkers supported diagnostic criteria maturity clinical routine still debated evaluate brain fluorodeoxyglucose positron emission tomography fdg pet measure cerebral glucose metabolism biomarker identify clinical prodromal according framework suggested biomarkers oncology using homogenous criteria biomarkers addressed parallel reviews fdg pet fully achieved phase rational use phase ability discriminate subjects healthy controls forms dementia aims phase aims early detection ability partly achieved phase studies routine use prodromal patients ongoing preliminary results extrapolated retrospective observations phase studies quantify impact costs performed results study show specific efforts needed complete phase evidence particular comparing combining fdg pet biomarkers properly design phase prospective studies basis phase evaluations elsevier inc rights reserved
magnetizer introduces variation flux density across sample rotational magnetization variation requires additional energy requirements limits attainable aspect ratios flux density levels stresses supply numerical methodology accounts flux leakage eddy currents proposed analyze uniformity variation four magnetizers analysis done beyond knee magnetization curve numerical results show round magnetizers mitigate variation square magnetizer making mmf sinusoidal equalizing reluctance along airgap addition deeper yokes minimized variation square halbach testers results analysis design mitigates variation combination sinusoidally distributed windings deep yoke proposed magnetizer achieved high flux densities relatively wide frequency range khz respectively
basis theory irreversible thermodynamics elementary model molecular motors converting chemical energy atp hydrolysis mechanical work exerted external force efficiencies molecular motors two different optimization configurations trade figure merit representing best compromise useful energy lost energy calculated upper lower bounds efficiency two different optimization configurations determined found optimal efficiencies two different optimization configurations always larger elsevier rights reserved
paper presents hydraulic actuator tendon drive system specifically designed lower limb exoskeleton provide high power low inertia dynamics actuator tendon system analyzed based exoskeleton system adaptive sliding mode trajectory tracking controller designed drive system stability proof indicates controller globally stable experimental results demonstrated controller provides high tracking accuracy robust external disturbances unmodeled nonlinearities moreover controller less errors conventional pid controller tests included joints exoskeleton conducted verify performance controller
pseudostellaria heterophylla various pharmacological effects include immunologic enhancement anti oxidation however remains unclear whether exerts beneficial effects dermatological diseases present study examined effects dinitrochlorobenzene dncb induced atopic dermatitis mouse model elucidated underlying mechanism action extract applied topically dncb treated dorsal skin mice every day days immunomodulatory effects evaluated measuring skin thickness mast cell infiltration serum levels immunoglobulin ige mrna expression levels helper pro inflammatory cytokines dorsal skin addition cluster differentiation cells detected dorsal skin immunohistochemistry topical application significantly reduced thickness dermis epidermis serum ige production compared dncb group treatment inhibited infiltration inflammatory cells including mast cells cells suppressed mrna expression levels cytokines interferon gamma interleukin beta tumor necrosis factor alpha associated immune response furthermore treatment significantly downregulated protein expression levels nuclear factor kappa phosphorylated inhibitor kappa alpha mitogen activated protein kinases results suggested may potential therapeutic strategy treatment via modulation levels
research heat transfer models geothermal ground heat exchangers ghes ground coupled heat pump gchp system recently advanced greatly however although important optimize design size ghes reducing total length ghes optimization ghes means models little paper describes interior simulation models borehole single tube double tubes buried analytical solutions concerning borehole exterior heat transfer given factors exert influences design size ghes described based results heat transfer models significant parameters consist centre centre distance tube thermal conductivity backfill material distance adjacent boreholes types circulating liquid underground medium arrangement boreholes minimum temperature circulating liquid enters heat pump using simulation models computer programming influence degrees factors discussed terms adoption different values types therefore initial cost economic performance system respectively dropped improved investigation optimization ghes favourable development gchp technology elsevier ltd rights reserved
paper presents reliable machine vision system automatically detect inserts determine broken unlike machining operations studied literature dealing edge milling head tools aggressive machining thick plates centimetres single pass studied cutting head tool characterised relatively high number inserts makes localisation inserts key aspect identification broken inserts critical proper tool monitoring system method propose first localise screws inserts determine expected position orientation cutting edge applying geometrical operations compute deviations expected cutting edge real edge inserts determine insert broken evaluated proposed method new dataset acquired made public obtained result harmonic mean precision recall shows machine vision system present effective suitable identification broken inserts machining head tools ready installed line system
background genetic differences target proteins metabolizing enzymes transporters contribute inter individual differences drug response integrated contemporary drug development programs ayurveda propelled many drug discovery programs albeit search new chemical entities incorporates inter individual variability prakriti development administration drug individualized manner prakriti individual largely determines responsiveness external environment including drugs well susceptibility diseases prakriti also shown molecular genomic correlates highlight integration prakriti concepts augment efficiency drug discovery development programs unique initiative ayurgenomics trisutra consortium methods five aspects carried analysis variability fda approved pharmacogenomics genes snps exomes healthy individuals including predominant prakriti types matched controls north indian indo european cohort establishment consortium network development five genetically homogeneous cohorts diverse ethnic geo climatic background identification parameters development uniform standard protocols objective assessment prakriti types development protocols prakriti evaluation application individuals five cohorts development data sample repository integrative omits pipelines identification genomic correlates results highlight study exome sequencing revealed significant differences prakriti types snps fda approved genes pharmacogenomics relevance viz cypc cypb esr pgr hla eila dqa hla drb ldlr cftr cps variations polymorphic diverse indian world populations included genomes project based phenotypic attributes prakriti identified anthropometry anatomical features biophysical parameters skin types hrv autonomic function tests spirometry vital capacity gustometry taste thresholds objective parameters comparison prakriti phenotypes across different ethnic age gender groups led identification invariant features well require weighted considerations across cohorts conclusion considering molecular genomics differences underlying prakriti relevance disease pharmacogenomics studies novel integrative platform would help identification differently susceptible drug responsive population additionally integrated analysis phenomic genomic variations would allow identification clinical genomic markers prakriti application personalized medicine also integration drug discovery development programs elsevier ireland ltd rights reserved
child abuse global public health problem serious social issue japan social support beneficial parents faced childrearing challenges aim study clarify association social support child abuse potential cross sectional study conducted using structured questionnaire target population mothers children nine public nursery schools bivariate multiple linear regression analysis performed examine effects socio demographic social support psychological distress factors child abuse potential among mothers high child abuse potential score bivariate analysis indicated mothers higher child abuse potential score likely divorced unmarried living single female parent households low perceived economic status low level child care support low multidimensional scale perceived social support mspss score high general health questionnaire score ghq important predictors child abuse potential among mothers surveyed included living single female parent households low perceived economic status low mspss score high ghq score improving approaches help mothers build social support relationships ease child rearing psychologically healthy condition recommended prevent child abuse elsevier ltd rights reserved
study used latent profile analysis develop coping typologies year old mexican american adolescents three typologies identified opposition coping adolescents tended use anger venting emotions support seeking coping adolescents relied seeking support escape opposition coping adolescents relied anger venting substance use coping behavioral avoidance peer support three key parental behaviors support knowledge psychological control mothers fathers adolescent gender examined predictors coping typologies results indicated parental support knowledge particularly mothers predicted membership support seeking coping typology relative two typologies girls likely boys utilize support seeking coping opposition coping gender socialization norms may influenced results discussed
years hiv first recognised usa epidemic continues pose disproportionate threat vulnerable marginalised populations increasing hiv incidence among young men sex men spurred debate around content approach hiv prevention interventions directed towards vulnerable population comprehensive model conceptualising content sexual health education described tailored unique needs experiences young men sex men application social theory vernacular knowledge incorporated manner nesting sexual health messages within shared understandings young men regarding sex sexual practices gender roles expectations community mores conventions shared knowledge sex sexuality critical pedagogy discussed way guiding one pedagogical approach intervention design implementation conducive individual empowerment community solidarity paper concludes strategies turning corner theory practice beginning formative research culminates design relevant community based sexual health education programmes young men sex men
immense endeavor mitigate global warming spite worse paper presents design implementation low power eco friendly refrigeration system using thermoelectric effect conventional refrigerators make use complex mechanisms involves synchronous operation various units namely compressor condensers expansion valves evaporator refrigerant thermoelectric refrigerator exploits principle peltier effect thus avoiding utilization complex components even helps curb release harmful chlorofluorocarbons cfcs atmosphere contributes increase global temperature moreover temperature controlled set required values help microcontroller hence used domestic commercial purposes unit eject harmful gases therefore heat expelled unit tapped heating utilities making use device versatile application thus proposal aims reducing air pollutants contributing also reducing power consumption
stringent emission norms rapid depletion petroleum resources resulted continuous effort search alternative fuels hydrogen one best alternatives conventional fuels hydrogen benefits limitation used fuel automotive engine system present investigation hydrogen injected intake manifold using hydrogen gas injector diesel introduced conventional mode also acts ignition source hydrogen combustion flow rate hydrogen set min load conditions injection timing kept constant top dead center tdc injection duration adjusted find optimized injection condition experiments conducted single cylinder four stroke water cooled direct injection diesel engine coupled electrical generator load maximum brake thermal efficiency hydrogen operation injection timing tdc injection duration degrees compared diesel oxides nitrogen emission hydrogen compared diesel smoke emissions reduced bosch smoke number bsn hydrogen compared diesel bsn hydrogen operation dual fuel mode diesel exhibits better performance reduction emissions compared diesel entire load spectra copyright john wiley sons ltd
paper presents novel single neuron adaptive pid controller system developed utilizing additional error inversed control signal plant output learning mechanism order update neuron connection weights additional error calculated difference inversed control signal inverse neural network input control signal plant actually additional error derived mathematically new quadratic error performance function utilized learning single neuron adaptive pid controller using new quadratic error performance function controller system convergence speed adaptive neuron increased control performance novel single neuron adaptive pid controller system greatly improved control system parameters rise time settling time overshoot system proposed algorithm compared classical single neuron adaptive pid controller system simulation results show control effect novel controller system outperformed classical single neuron adaptive pid controller especially strong robustness better self adaptation characteritics
purpose work examine relationships geographical coordinates prevalence winter depression sad compare sleep characteristics chronotype youths without sad conducted cross sectional study self reported sleep characteristics chronotype winter depression northern european russia two questionnaires munich chronotype questionnaire mctq seasonal pattern assessment questionnaire spaq administered total adolescents aged years males females prevalence sad study population sub sad four variables predicted likelihood sad youths sex higher females odds ratio age increases age latitude higher north position time zone higher west later sleeping waking longer sleep latencies severe sleep inertia shorter total sleep times lower sleep efficiencies observed males females sad influence sad sleep characteristics pronounced school days significant phase delays sleep wake rhythm severe social jetlag difference mid point sleep phase weekends workdays observed females sad males significant differences sleep characteristics chronotype people sad sad demonstrate latitude residence location within time zone significant predictors sad young inhabitants north
new directional solidification technique presented technique employs pyrolytic graphite heat dissipation conduction withdraw cast furnace design presented static solid cooling ssc method heat dissipation model put forward evaluating cooling efficiency calculating total thermal resistance directional solidification total thermal resistance ssc method minimum compared methods solidification process simulated results show axial temperature gradient increases degrees degrees bridgman method growth rate improved min min bridgman method solidification time reduced cooling rate increases dramatically well additionally heat insulation hot cool zones improved substantially ssc method thermal resistance mould reduced well due thin mould besides ssc method employs electrical network control growth rate solidification condition much uniform due position control electrical network elsevier rights reserved
objective gestational diabetes mellitus gdm characterized insulin resistance diagnosed pregnancy although pregnancy diabetogenic state women develop gdm genetic factors together enviromental factors cause maladaptation maternal pancreas diabetogenic state gdm develops adamts recently recognized molecule whose genetic variants risk gdm decreased levels already shown fetal membranes maternal serum levels protein studied yet hypothesized alteration adamts expression cause changes maternal serum levels could help identify disease develop new treatment strategies materials methods prospective case control study consisted pregnancies gdm healthy singleton pregnancies matched matenal age gestational week maternal weight gdm diagnosis made oral glucose tolerance test adamts levels compared groups results adamts levels range gdm group range control group adamts levels affected maternal age gestational age maternal weight conclusion adamts levels significantly lower gdm pregnancies may help understand mechanism gdm pathogenesis future target treatments adamts proteins may help improve severity diabetes pathogenesis
purpose reviewthe purpose study encourage discussion reproduction issues patients fertile age order prevent unplanned ill timed pregnancies patients rheumatoid arthritis recent findingscounselling patients desire children requires consideration relevant reproductive health issues including fertility interaction pregnancy management pregnancy lactation patients disease related restrictions regard contraception need counselled safe birth control particularly treatment potentially teratogenic drugs spite mostly beneficial effects pregnancy active disease aggressive drug treatment impair pregnancy outcomes options drug therapy though limited may help maintain low disease activity pregnancy lactation summarycareful preconception counselling risk assessment important women particular focus preventing unplanned pregnancy information contraception antibody status medications need reviewed pregnancy maintaining low disease activity pregnancy crucial good outcomes preconceptional counselling shared health professionals engaged care patient helps ensure healthy pregnancy outcomes mother child
background purpose sensory hyperreactivity shr patients symptoms airways chest induced environmental irritants like scenting products cigarette smoke characterized increased cough reaction inhaled capsaicin compared healthy controls lung function tests normal asthma medications little effect recent published article patients shr found impaired chest mobility increased pain sensitivity purpose study evaluate physiotherapeutic intervention increase chest mobility shr influence patients symptoms reduce capsaicin cough sensitivity methods forty one shr patients initially randomized groups one training one symptom registration controlled training study consisted daily training programme containing simple movements increase flexibility chest breathing exercise relaxation session well symptom registration chest expansion measured measuring tape thoracic abdominal movement light sensors pain sensitivity assessed using pressure algometry standardized capsaicin inhalation threshold provocation evaluated cough sensitivity results twenty seven patients left analyses weeks patients weeks chest mobility upper thoracic respiratory movements improved feeling chest pressure capsaicin cough sensitivity decreased patients also showed significantly lowered pain pressure thresholds measured algometry compared healthy controls conclusion improvement chest mobility physiotherapeutic intervention indicates patients may acquired dysfunctional breathing pattern regular use training programme structural breathing instructions used improve chest mobility chest symptoms capsaicin cough sensitivity patients shr signs dysfunctional breathing copyright john wiley sons ltd
automata synchronization many important applications mostly conformance testing electrical circuits self correcting codes protocol testing finding shortest synchronizing word done polynomial time assuming equal situations especially large automata finding word almost impossible therefore accept synchronizing word reasonably short calculated short time existing algorithms either polynomial quick optimal exponential exact useless case large automata paper present flexible algorithmic framework synchronization allows user parameterize algorithm obtain desired balance terms trade memory usage runtime optimality also discuss many practical issues affect efficiency implementation particular design new polynomial backward algorithm works significantly better previously used heuristic algorithms finally present detailed results experiments involving automata states compare algorithms various settings known algorithms check impact different parameters results elsevier ltd rights reserved
effects video games children psychosocial development remain focus debate two timepoints year apart children years old male reported gaming frequency tendencies play violent video games game cooperatively competitively likewise parents reported children psychosocial health gaming time one associated increases emotion problems violent gaming associated psychosocial changes cooperative gaming associated changes prosocial behavior finally competitive gaming associated decreases prosocial behavior among children played video games high frequency thus gaming frequency related increases internalizing externalizing attention peer problems violent gaming associated increases externalizing problems children playing approximately per week frequent competitive gaming may risk factor decreasing prosocial behavior argue replication needed future research better distinguish different forms gaming nuanced generalizable insight
anterior cingulate cortex acc implicated different aspects cognition decision making including social cognition several studies suggest region actually formed sub regions concerned distinct cognitive functions acc usually divided rostro caudal axis caudal acc playing major role processing actions rostral acc related social cognition recently suggested acc also functionally divided dorso ventral axis acc gyrus accg acc sulcus accs accg central role processing social information context propose pregenual accg might especially important engaging social interactions discuss previous findings support hypothesis present evidence suggesting activity pregenual accg neurons modulated spontaneous social interactions
mitochondrial ferritin ftmt type ferritin sequesters iron previous studies shown ftmt expressed dopaminergic neurons substantia nigra may involved pathology parkinson disease however functional roles ftmt dopaminergic neurons remain unclear study investigated function ftmt synuclein regulation antioxidant roles dopaminergic cells using human dopaminergic neuroblastoma cells syy physiological conditions ftmt knockdown increased synuclein expression protein level mrna level contrast ftmt overexpression reduced alpha synuclein expression protein level mrna level ftmt enhanced iron levels mitochondria decreased iron levels intracellular labile iron pool found fecl could abolish effects ftmt overexpression synuclein expression oxidative stress conditions induced found treatment induced ftmt synuclein expression mrna protein levels dose dependent manner ftmt overexpression protected cells oxidative stress alleviated enhanced synuclein expression induced posttranscriptional level results indicate ftmt modulates alpha synudein expression posttranscriptional level via iron regulation physiological conditions ftmt expression enhanced oxidative stress conditions ftmt protects cells oxidative stress well plays important role maintaining synuclein levels published elsevier inc
objective aim study investigate relation vitamin levels vertebral defoi functional status quality life acute phase reactants enthesopathy patients psoriatic arthritis psa patients methods fifty two patients psa controls enrolled study routine blood tests serums measured thoracic lumbar vertebrae deformities identified radiographies evaluated radiologist psoriatic arthritis quality life psaqol used evaluating quality life disease activity parameters psa assessed psa patients correlations performed levels pga patient global assessment phga physician global assessment tender joint count haq health assessment questionnaire ondyloarthropathies psaqol mases maastricht ankylosing spondylitis enthesitis score basdai bath ankylosing spondylitis disease activity index values results results showed levels correlated values respectively determined psaqol score positive statistically significant correlation pga swollen crp hgd tender vas pain haq mases basdai values psa patients respectively statistical analyses demonstrated psa patients vertebral deformities higher numbers tender joints prolonged periods morning stiffness higher das esr disease activity score scores higher levels vitamin respectively multiple logistic regression analysis indicated factor effect development vertebral deformities use steroids conclusions result demonstrated psoriatic arthritis considerable effect patient quality life significant factors affecting quality life physical pain disability vertebral deformities significant effect
early androgen exposure known long lasting effects phenotype behaviour even fitness difficulties measuring exposure hinders study importance evolutionary context digit ratios highlighted potential easy measure indicator early steroid exposure suggested reflect steroid mainly testosterone levels prenatal development however evidence digit ratios reflecting early steroid levels weak experimental studies especially wild populations scarce studied association maternally derived yolk androgens digit ratios using correlative data rather high level experimental elevation yolk androgens passerine bird pied flycatcher ficedula hypoleuca also examined whether digit ratios indicator value evolutionary context studying correlations digit ratios reproductive traits secondary sexual traits exploratory behaviour find association digit ratios yolk androgen level either correlative experimental data digit ratios neither related reproductive secondary sexual traits exploratory behaviour measured however sex difference adult birds due second fourth digits shorter females apparent fledglings captivity raised juveniles suggests either sex difference may develop late sexual maturation breeding results indicate species digit ratios reliable markers maternally derived yolk androgen exposure bear little relevance correlates adaptive traits measured
paper conduct research differences uighur han chinese communication etiquette customs psychological characteristics cross cultural environment empathy process cross cultural communication subject adapts good better means communication cross cultural communication must improve sensitivity taboo taboo customs different peoples nations way eliminate communication barriers conflict achieve smooth harmonious language communication article use theory intercultural communication understanding uygur traditional culture dissolve contradictions obstacles communication article two aspects language communication nonverbal communication process cross cultural communication problems enumerated analyzed meaningful
atheists often marginalized discussions religious spiritual pluralism college campuses beyond minority worldview groups atheists face challenges hostile campus climates misunderstanding views present study used large multi institutional sample explore predictors non atheist college students appreciative attitudes toward atheists substantial differences found across identities secular spiritual worldview groups hold positive views whereas christians muslims negative attitudes interactions worldview diversity general religious spiritual engagement consistently predict positive attitudes relationships sometimes vary based students worldviews results suggest colleges universities create inclusive environments atheists constitute sizable minority group today college campuses
analog implementation deep machine learning system efficient feature extraction presented work features online unsupervised trainability non volatile floating gate analog storage utilizes massively parallel reconfigurable current mode analog architecture realize efficient computation leverages algorithm level feedback provide robustness circuit imperfections analog signal processing layer node analog deep machine learning engine fabricated standard cmos process occupying active area processing speed input vectors per second consumes supply achieving operation per second per watt peak energy efficiency measurement demonstrates real time cluster analysis feature extraction pattern recognition fold dimension reduction accuracy comparable floating point software simulation baseline
burgeoning research documented high rates maltreatment first years life early exposure maltreatment related host negative physical developmental mental health outcomes childhood adulthood scientists documented biological embedding maltreatment including alterations structures processes young brain maltreatment complex phenomenon manifests contexts family poverty inadequate parental knowledge skill regarding child development caregiving social isolation parents disruptions parent child relationships compromised parental psychological functioning concrete issues affect parenting capitalizing research young child maltreatment interventions designed ameliorate infant toddler maltreatment buffer young children effects maltreatment promote well maltreated young children growing empirical base interventions address early maltreatment within context public health prevention framework primary prevention programs aim reduce incidence maltreatment related outcomes infants toddlers families implementation population based programs home visiting early care education programs secondary prevention models target families specific risk factors associated maltreatment maternal depression tertiary programs generally entail involuntary services designed prevent maltreatment recurrence improve parenting skills therapeutic approaches targeting parent child dyad empirical knowledge maltreated young children families interventions support inform design delivery child welfare services
paper aims designing nonasymptotic robust pseudo state estimator class fractional order linear systems transformed brunovsky observable canonical form pseudo state space representation unknown initial conditions first form expressed fractional order linear differential equation involving initial values fractional sequential derivatives output based modulating functions method applied former initial values fractional derivatives output exactly given algebraic integral formulae using recursive way used nonasymptotically estimate pseudo state system noisy environment second pseudo state estimator studied discrete noisy case contains numerical error due used numerical integration method noise error contribution due class stochastic processes noise error contribution analyzed error bound useful selection design parameter provided finally numerical examples illustrate efficiency proposed pseudo state estimator comparisons fractional order luenberger like observer new fractional order infinity like observer given
great importance many applications provide stable output power gyrotron traveling wave tube gyro twt long operation time several hours order achieve goal automatic hot test platform gyro twts set power stabilization obtained adaptive scheme proportional integral derivative pid feedback beam current controlled filament heating power cathode anode beam voltage determined operating parameters pid controller adaptively adjust beam current voltage maintain output power target pid controlling process effectively eliminate influence power supply voltage surge cathode emission instability automatic hot test gyro twts shows pid feedback controlling accuracy output power better
order global order strings related unique maximal factorization families umffs generalizations lyndon words order recently proposed alternative lexicographic order computation suffix arrays suffix sorting induced burrows wheeler transform efficient ordering strings thus becomes matter considerable interest paper discover several new combinatorial properties order explore computational consequences particular fast simple line order comparison algorithm requires auxiliary data structures elsevier rights reserved
purpose reviewglutamine abundant amino acid plasma plays key role maintaining integrity intestinal barrier recent findingsexperimental studies showed glutamine able modulate intestinal permeability tight junction protein expression several conditions recent articles underlined putative beneficial role gastrointestinal disorders irritable bowel syndrome summaryglutamine major nutrient maintain intestinal barrier function animals humans depletion glutamine results villus atrophy decreased expression tight junction proteins increased intestinal permeability moreover glutamine supplementation improve gut barrier function several experimental conditions injury clinical situations furthermore preventive effects glutamine experimental models intestinal injuries recently reported despite promising data experimental models studies needed evaluate glutamine supplementation clinical practice
objectives study describe illness representations dementia caregiving examine relationship illness perceptions carers sense coherence illness perceptions assessed brief illness perception questionnaire measured sense coherence symptoms anxiety depression carer burden regression analyses indicated controlling demographic factors burden psychological distress carers illness coherence emotional responses disease independently contributed towards explaining variance carers sense coherence results provide support usefulness self regulation model understanding dementia caregiving
computer programming notoriously difficult learn end regular practice form application reflection important enabler student learning however educators often find first year students readily engage activities providing student programmable robot however could used facilitate application reflection since potentially robots facilitate engaging learning experiences providing immediate intuitive feedback paper explores whether introductory course centered upon programming personal robots preparation end course event day robot olympics help students first engage programming practice frequently second improve quality code survey conducted examine students programming practice behavior students final coursework submissions also reviewed aspects program quality findings cohort compared reference group previous cohort shared similar learning objectives entry requirements focused web programming instead using robots results reveal statistically significant increases programming practice compared reference group furthermore enrolled course culminated robot olympics significant predictor two aspects program quality functional coherence sophistication suggests robot centered courses promote engagement enhance aspects programming practice
order reduce winding temperature furthest adopted method adding micron grade filler base resin prepared three kinds modified high thermal conductivity adhesive specimens class time four kinds performance tests water absorption adhesive strength breakdown strength thermal conductivity done test results showed specimen iii adhesive highest thermal conductivity finally specimen iii adhesive selected testing new insulating system developed consists specimen iii adhesive self made slot wedges insulating paper applied new insulating system motors observed changing results winding temperature load loss results showed winding temperature could decrease load loss also decrease correspondingly meantime motor efficiency increases compared original state improves nearly thus research indicates new high thermal conductivity adhesive class could lower temperature windings improve motor efficiency simultaneously great significance practical application
generalized linear image processing systems developed physical image formation models human visual perception models mathematical models although many papers extension parameterization symmetrization systems lacking unified framework development study systems performed based common ground paper propose conceptual image sensor models light energy converted sensor data proposed sensor model input energy regarded random variable conversion cumulative distribution function based sensor model suggest statistical framework new systems derived existing seemingly unrelated systems studied unified perspective proposed statistical framework provides principled way symmetrizing systems even extension probability distribution function pdf natural way parameterization systems parameters pdf paper demonstrate new applications statistical framework numerical approximation lower incomplete gamma function enhancement dynamic range manipulation sharpness images using scalar multiplication operation parametric system application new system fusion multi exposure images application three new systems correction incorrect exposure
purpose purpose paper present finite element formulation enhanced two node parabolic cable element static analysis cable structures design methodology approach unlike assumed polynomial displacement interpolation functions present approach uses analytical cable dynamic stiffness matrix obtain explicit expression static stiffness matrix inclined sagging cable setting frequency zero newton raphson based iterative method used obtain solution findings demonstrated present results agree well obtained nonlinear analytical theory parabolic cable previous reported methods literature originality value paper proposes two node parabolic cable element comparable accuracy truss element method fewer numbers cable elements needed
long term goal virtual physiological human digital patient projects run simulations health disease processes virtual digital patient use results make predictions real health determine best treatment specifically individual termed personalized medicine intended future healthcare people interact engage virtual selves virtual models used motivate people actively participate healthcare discuss questions describe current efforts integrate realistically embody psychobiological models face face interaction enliven increase engagement virtual humans healthcare overall paper highlights need attention design human machine interfaces address patient engagement healthcare
paper presents actuator based coil placed casing specially prepared connection rods construction allows installation fiber bragg grating sensors inside coil allows measure deformation composite located core coil thanks signal generation use dasylab software possible precisely control frequency value amplitude excitation send signal system use measurement card main goal experiment keep constant value deformation means feedback loop use pid control change initial conditions test change external force system designed return initial settings appropriate control intensity magnetic field thus deformation sample
article presents dynamical modelling novel active aeroelastic structure adaptive torsion wing concept thin wall two spar wingbox whose torsional stiffness adjusted translating spar webs chordwise direction inward towards using internal actuators reduction torsional stiffness allows external aerodynamic loads induce twist structure maintain deformed shape adaptive torsion wing system considered integrated within wing representative unmanned aerial vehicle replace conventional ailerons provide roll control adaptive torsion wing modelled two dimensional equivalent aerofoil using bending torsion shape functions express equations motion terms twist angle plunge displacement wingtip full equations motion adaptive torsion wing equivalent aerofoil derived using lagrangian mechanics aerodynamic lift moment acting aerofoil modelled using theodorsen unsteady aerodynamic theory low dimensional state space representation empirical theodorsen transfer function adopted allow time domain analyses four actuation strategies investigated figures merit including plunge displacement twist angle actuation forces actuation powers quantified discussed scenarios study allows conceptual design sizing internal actuators required drive webs
easy growing artist find poetry smart materials could answer looking new forms art smart material interfaces smi define new interaction paradigm based dynamic modifications innovative materials properties smi applied different domains used different purposes functional communicative creative paper focus experimenting art creative communication domain particular describe results workshop held students fine arts academy venice learned make program smi took advantage new skills design variety interesting creative artifacts
background glutamatergic system abnormalities implicated pathophysiology treatment major depressive disorder bipolar depression bdep subsequent studies demonstrating rapid robust antidepressant effects ketamine methyl aspartate receptor antagonist glutamatergic modulators studied clinical trials mood disorders previous open label study found riluzole administered combination mood stabilizer lithium antidepressant effects methods conducted randomized double blind placebo controlled trial riluzole monotherapy treatment bdep nineteen subjects aged years bipolar disorder currently experiencing depressive episode tapered excluded medications randomized receive riluzole placebo weeks rating scale scores montgomery angstrom sberg depression rating scale hamilton rating scale depression hamilton rating scale anxiety young mania rating scale obtained weekly results significant differences depressive symptoms observed subjects treated riluzole receiving placebo anxiety scores significantly lower placebo group interim analysis conducted resulted stopping study futility subjects achieved treatment response conclusions although found change severity depressive symptoms bdep patients receiving riluzole compared placebo trial limited relatively high number subject withdrawals small sample size thus riluzole monotherapy demonstrate efficacy bdep studies examining riluzole adjunctive therapy disorder may warranted
graphene oxide prepared graphite using hummer method nanoparticles rim average size successfully obtained via situ nanoparticles deposition onto graphene oxide using microwave method finally resulting graphene water uptake increased content nafion composite membrane due hydrophilic nafion composite membrane much lower nafion composite membrane meas fabricated nafion composite membrane show significant enhancement cell performance relative humidify content composite membrane respectively compared casting nafion membrane nafion composite membrane however show sufficient enhancement various rhs attributed poor water retention ability hydrophobic graphene electron loss due formation electrical network much within membrane constant open circuit voltage ocv low indicates graphene could prospective filler low humidifying polymer electrolyte fuel cell elsevier rights reserved
objective examine effects using cognitive reappraisal find positive gains caregivers depressive symptoms burden psychological well method ninety six caregivers persons alzheimer disease randomly assigned receive benefit finding intervention treatment usual conditions namely simplified psychoeducation lectures sim standard psychoeducation std participant received biweekly interventions month period home results results showed benefit finding participants reported lower depressive symptoms treatment compared either sim std participants also reported less role overload compared std participants self efficacy controlling upsetting thoughts mediator treatment effects conclusion finding positive gains effective intervention reduce depressive symptoms among alzheimer caregivers
product design use composite materials steadily growing aircraft industry driven primarily weight lost structural components leads better efficiency fuel consumption closely linked economic issues sustainability manufacturing planning use lean concepts helped aircraft manufacturers better manage production resources leading also efficient sustainable ways fabricate assemble aircraft structures paper describes embraer combining two philosophies development vertical horizontal stabilizers latest product legacy planning construction new composites assembly line evora first analysis automated composites fabrication methods like atl help reduce parts thus reducing weight assembly hours also analysis solutions developed guarantee design assembly design automation concepts going product design manufacturing planning line presents layout monorail allows assembly stabilizers determined rates flexible enough used new products absorb rate changes highly flexible automation robots used panel drilling fastening zero gravity system applied lift heavy components monorails working benches applications result high quality products efficient production methods ultimately generate sustainable way manufacture aircraft components
leak current channel nalcn regulates locomotion respiration intellectual development previous work highlighted striking similarities characteristic movement phenotypes nalcn deficient animals drosophila caenorhabditis elegans major symptoms parkinson disease primary progressive freezing gait discovered novel physiological connections nalcn channels gap junctions mediate regulation locomotion elegans drugs block channels gap junctions activate channels significantly improve movement nalcn deficient animals loss function nalcn creates imbalance ions including interferes normal cycles depolarization repolarization work suggests new therapeutic strategies certain human movement disorders comp neurol wiley periodicals inc
parkinson disease progressive neurodegenerative disorder characterized motor system disorders resulting loss dopaminergic neurons cxc novel tetramethylpyrazine derivative shown strongest neuroprotective effects due antiapoptotic activity however whether cxc protects neuronal damage mechanisms underlying beneficial effects unknown purpose study investigate potential neuroprotective role cxc elucidate mechanism action hydroxydopamine ohda induced mouse model cxc administration improved neurodegeneration mice induced ohda findings confirmed treatment cxc dose significantly inhibited apoptosis decreasing level cleaved caspase bax increasing level bcl ohda lesioned mice meanwhile ohda also decreased amount phosphorylated akt increased gsk beta activity amount phosphorylated gsk beta ser decreased prevented cxc wortmannin specific pik inhibitor dramatically abolished changes induced cxc study firstly demonstrated cxc protected neurodegeneration ohda induced model anti apoptotic properties pik akt gsk beta signaling pathway involved
paper present methods directly model random structure porous media using voronoi tessellations three basic structures generated correspond porous medium geometries intersecting fractures granular interconnected tubes tubular fibers fibrous fluid flow models solved massively parallelized lattice boltzmann code established porosity permeability relations basic geometry models found granular tubular geometries specific surface area critical structural parameter bring porosity permeability relations together unified kozeny carman equation connected fracture network superimposed basic voronoi structure increases dimensionless permeability relative kozeny carman equation isolated large pores vugs hand decreases dimensionless permeability relative kozeny carman equation kozeny carman equation however distinguish heterogeneous structure embedded partially penetrating fracture porosity permeability relation fibrous geometries general agrees established simple cubic body centered cubic face centered cubic models dilute limit however dependence solid fraction weaker voronoi geometries indicating weaker hydrodynamic interactions among randomly interconnected fibers idealized models elsevier ltd rights reserved
article presents design current differencing transresistance amplifier cdtra controlled output voltage gain output terminals offer current voltage signals furthermore circuit theoretically temperature insensitive preferable use temperature variation work pspice simulation results confirm cdtra addition application grounded inductance simulator disclosed total power consumption power supplies authors published elsevier
orthogonal frequency division multiplexing ofdm popular transmission format emerging wireless communication systems including satellite radio various wireless local area network lan standards digital broadcast television single carrier cyclic prefixed sccp modulation similar ofdm frequency domain operations performed receiver systems employing ofdm sccp perform well presence multipath provided channel delay spread shorter guard interval transmitted blocks condition met channel shortening equalizer used shorten channel desired length modestly time varying environments adaptive channel shortener interest existing adaptive channel shorteners require renormalization restrain channel shortener away zero paper study use unit tap constraint rather unit norm constraint adaptive channel shortener use constraint manipulate existing algorithms framework analogous recursive least squares algorithm develop adaptation rules blind semiblind frequency domain equalizers sccp receivers simulations proposed algorithms show order magnitude improvement convergence speed well reduced asymptotic bit error rate
verbal nonverbal communication one important factors socialization therefore teachers place great emphasis development earliest age taking account playing main activity kindergarden teaching activities linked playing interesting games meant raise children interest teacher say wants class game based activities common teaching communication language developing children learn easier remember newly taught words use spontaneously creatively also try communicate fluently clearly games develop imagination creativity paper aims present experiment results obtained sample preschool period weeks subjected game based activities aimed developing language communication parallel results presented control group results demonstrate effectiveness program designed implemented
article argue sustainable development possible without affordable inclusive growth inequality unsustainability linked unless world able look environmental solutions affordable meet needs work
perfectionism personality trait multidimensional nature providing new multidimensional measure perfectionism smith saklofske stoeber sherry developed big three perfectionism scale btps btps shown good psychometric properties yet subjected psychometric analyses across cultures present research aimed translate validate btps iran present investigation examined factor structure btps using exploratory factor analyses well convergent validity facet factor level reliability coefficients study university students structure higher order models btps using confirmatory factor analyses examined study community adults evidence convergent validity community sample also replicated study overall current findings provided support psychometric properties farsi translation btps iranian population consequently newly developed measure may used clinical research settings iran published elsevier ltd
objective boredom defined aversive experience wanting unable engage satisfying activity associated number psychosocial psychopathological problems aim paper test validity italian version multidimendional state boredom scale msbs results investigation indicate italian msbs factor structure similar original msbs furthermore evidence italian msbs strong reliability method total undergraduate students participated research participants male female mean age years range years two studies conducted first study confirmatory factor analysis performed determine whether data italian msbs fit original msbs factor structure second study association italian version msbs several related measures examined related measures boredom proneness scale dissociative experiences scale beck depression inventory beck anxiety inventory eysenck personality questionnaire short version behavioural inhibition system behavioural activation system results study found italian translation msbs administered italian speaking sample yielded factor structure original msbs study found italian msbs demonstrated construct validity italian sample conclusions results present paper demonstrate italian version msbs valid reliable study found italian msbs similar factor structure original english msbs italian msbs factors significantly associated one another italian msbs good reliability study demonstrated msbs valid related number theoretically important constructs
aiming problem fixed radio frequency identification rfid system lightweight cryptography may easily illegally controlled communication authentication protocol based quantum key distribution using decoy state method proposed developed study new rfid system model using quantum key distribution introduced indicates quantum keys distributed rfid tags reader epc information server via weakly coherent photons transmitted optical fiber work mainly presents protocol description detailed theoretical analyses including rfid system initialization transmission reception acquisition random quantum key authentication process epc information server rfid tag reader security analysis protocol finally carried proves proposed protocol prevent various eavesdropper attacks solid security
research addresses three important issues regarding interpersonal expectancy effects communication across various modalities phenomena behavioral confirmation disconfirmation tested original experiment involving participants using computer mediated communication cmc first study tested boundary condition asserted previous theorists whether confirmation disconfirmation could occur communication channels without nonverbal communication secondly shed light important causal variable perceived malleability interpersonal expectancies novel simultaneous test confirmation disconfirmation lastly verified hyperpersonal model cmc demonstrating behavioral confirmation extended model specifying disconfirmation occurs online
paper tests hypothesis association childhood maltreatment adult personality dysfunction least partially attributable insecure attachment attachment style mediates relationship childhood maltreatment adult personality dysfunction associations childhood trauma measured childhood trauma questionnaire ctq anxious avoidant attachment romantic relationships measured experiences close relationships revised ecr five personality domains measured severity indices personality problems sipp examined sample psychiatric inpatients sipp domains included relational capacities identity integration self control responsibility social concordance direct effect childhood trauma sipp domains significant controlling indirect effect attachment regression modeling significant indirect effect childhood trauma via adult attachment style found sipp relational capacities identity integration self control social concordance specifically anxious attachment significant mediator effect childhood trauma self control identity integration relational domains results suggest childhood trauma impacts broad range personality domains large part pathway anxious romantic attachment style
background invasive fungal tracheobronchitis ift severe form pulmonary fungal infection limited immunocompromised patients although respiratory failure crucial predictor death information regarding ift critically ill patients limited methods retrospective multicenter observational study enrolled adults diagnosed ift admitted intensive care unit january december demographics clinical imaging data bronchoscopic histopathological findings outcomes recorded results study included patients diagnosed ift comprising men women mean age years patients developed respiratory failure received mechanical ventilation diagnosis eighteen patients diabetes mellitus chronic lung disease four patients hematologic disease none patients neutropenia twenty five patients diagnosed proven ift remaining patients probable ift aspergillus spp common pathogenic species followed mucorales candida spp diagnoses six patients confirmed bronchial biopsy histopathological examination whereas cultures bronchoalveolar lavage fluid negative fungi overall hospital mortality rate conclusions ift critically ill patients results high mortality rate diabetes mellitus prevalent underlying disease followed chronic lung disease addition aspergillus spp mucorales another crucial pathogenic species bronchial lesion biopsy key diagnostic strategy
objectivethe goal study compare novel wireless phone web based technology record store overactive bladder symptoms oab traditional pen paper micturition chart methodsoveractive bladder symptoms recorded period days using electronic micturition chart emc standard pen paper micturition chart twenty nine men lower urinary tract symptoms luts included study dropout rate patient preference correlation quality life measures qol symptoms recorded emc versus assessed compared resultsof total number patients enrolled study completed full day trial using using emc preferred emc preferred participants using patients forgot record least one episode urgency versus using emc forgot record least one micturition using versus using emc statistically significant correlation found lower severity oab higher qol using recording methods conclusionsin study population recording symptoms emc prove preferable compared however emc provided level accuracy better adherence study protocol
postpartum depression ppd growing mental health concern new mothers fathers purpose study determine predictors depression months postpartum comparing depressed couples couples one depressed partner depressed partner using data alberta pregnancy outcomes nutrition study data mothers fathers collected second trimester months postpartum results showed predictors ppd mothers low household income high prenatal depressive symptoms postnatally low social support higher number stressful life events fathers similar predictors including low household income high prenatal depressive symptoms postnatally low social support smoking compared non depressed couples factors predicted ppd mothers fathers couples included low income high prenatal depressive symptoms mothers low prenatal social support reported fathers
prospective cohort study evaluated relationship hamstring lumbar spine flexibility hamstring injury sixty seven senior male australian rules footballers videotaped performing toe touch test erect standing peak motion measurement system used obtain measurements end range hip flexion lumbar flexion toe touch distance ttd ratio lumbar spine flexion hip flexion following football season eight subjects per cent sustained hamstring strain results showed significant difference hamstring injured uninjured players measured variables variable able predict likelihood injury cohort toe touch test would appear useful screening tool identify footballers risk hamstring strain
subtype microglia defined morphological appearance cells rod shaped little known intriguing cell type case reports describing rod shaped microglia neuropathological literature rod shaped microglia shown recently account substantial proportion microglia cells hippocampus demented cognitively intact aged individuals hypothesized aging could defining feature occurrence rodshaped microglia test hypothesis independent series autopsy cases total cases covered adult lifespan years old included study presence absence rod shaped microglia scored iba immunohistochemically stained slides hippocampus cortex found age one strongest determinants presence rod shaped microglia hippocampus cortex found association presence rod shaped microglia self reported history tbi alzheimer diseaseerelated pathology found influence presence rod shaped microglia parietal cortex hippocampus temporal cortex future studies warranted determine functional relevance rod shaped microglia supporting health neurons aged brain signaling processes regulate formation rod shaped microglia elsevier inc rights reserved
study presented paper discusses developments area anti lock braking control full electric vehicles main contributions paper development experimental validation combined electric hydraulic brake system application continuous anti lock braking system expected effective existing industrial solutions covers topic high performance braking driving comfort direct slip control function research related full electric sport utility vehicle equipped four individual board motors decoupled electrohydraulic brake system brake controller architecture includes functions continuous anti lock braking system strategy brake blending algorithm aimed minimization friction brake torque operational limitations electric brakes developed brake controller subjected different validation procedures within framework paper emergency braking tests wet surface low coefficient friction considered results obtained demonstrate significant improvements braking performance driving comfort control performance continuous anti lock braking control electric vehicle compared diverse vehicle configurations particular sport utility vehicle type equipped internal combustion engine conventional hydraulic brake system
occupational allergies among frequently recorded occupational diseases years skin well respiratory tract may affected estimated adult asthma partially caused work related exposure gender specific differences exposure cause different risks workplace affect health employees also applies exposure working conditions handling sensitizing working substances gender specific analysis presented based german documentation confirmed occupational allergic diseases airways skin reveals clear differences men women numbers diseases also exposure condition working areas
modern experimental setups generate prolonged intense data streams example non contact measurement techniques piv particle image velocimetry based continuous image processing widely used experimental aerodynamics hydrodynamics experimental stereo volumetric velocimetry piv setups able generate long lasting intensive flows images using two cameras high computational complexity image processing algorithms main limiting factor conditions low computational performance piv setups removal limitations moving image processing tasks remote supercomputer using proposed technology distributed piv allow users apply new high precision parallel algorithms real time implement feedback experimental setup paper describes innovative technology high performance processing intensive flows structured data generated experimental setup delivered high speed dwdm backbone directly computing nodes remote supercomputer high bdp bandwidth delay product problem case design protocols tcp respect performance tuning achieve maximum network throughput solved designed middleware elsevier inc rights reserved
whathydraulic information gained remotely sensed observations river surface study weanalyze relationship river bed undulations water surfaces ungauged reach xingu river first order tributary amazon river braided reach crosscut times envisat environmental satellite track extends rating curves based modeled discharge series altimetric measurements used including zero flow depth parameter describes river bathymetry river widths determined jers japanese earth ressources satellite images hydrodynamic laws predict irregularities geometry river bed produce spatial temporal variations water level well slope observation changes goal surface water ocean topography satellite mission final objective determining river discharge first concept hydraulic visibility introduced seasonality water surface slope highlighted along different flow regimes reach behaviors propose new single thread effective hydraulic approach modeling braided rivers flows based observation scales current satellite altimetry effective hydraulic model able reproduce water surface elevations derived satellite altimetry shows hydrodynamical signatures visible areas river bed morphology varies significantly reaches strong downstream control results study suggest longitudinal variations slope might interesting criteria analysis river segmentation elementary reaches surface water ocean topography mission provide continuous measurements water surface elevations slopes reach widths
paper presents applied research fuzzy logic modeling forecast distribution salinity coastal region southern tamil nadu india geoelectrical resistivity data used research apart nominal approach salinity forecasting using geochemical data analysis data collected using vertical electrical sounding ves method fed input fuzzy inverting algorithm evaluate true resistivity thickness subsurface layers inverted resistivity values subjected fuzzy rule based approach salinity forecasting classifications made basis linguistic variables five linguistic terms resistivity range using triangular membership function fuzzy logic purpose find saltwater intrusion coastal region tuticorin district tamil nadu india research work reveals fuzzy logic would effective tool solving complex problems well enhancement integrating multiple features necessary study results overlain surrounding regions mapped threatening zones hence mark pre awareness regions rainwater harvesting system avoidance human anthropogenic activities need implemented
goal current study explore information search processing differences individuals less numerate attempt better understand mechanisms might differentiate choices make using computerized process tracing system known mousetrace presented monetary gambles alternative attribute matrix outcome dollar amount probability information attributes information initially occluded could revealed clicking cell contained desired information beginning nine gambles offering chance gaining losing specified amount participants narrowed options three one using inclusion exclusion strategy consistent previous research inclusion effortful strategy individuals higher numeracy likely select prospects highest expected value process measures revealed individuals expended effort attended sought information processed greater depth exhibited compensatory processing lower numeracy sometimes depended whether one asked include exclude results serve evidence individuals higher levels numeracy often engage elaborative processing decision task tends lead optimal choices however also suggest individuals adaptive specific situation matter copyright john wiley sons ltd
chronic stress precipitating factor disorders including depression basolateral amygdala bla critical substrate interconnects stress modulated neural networks generate emotion mood related behaviors current study shows per day restraint stress days caused mice exhibit long term depressive behaviors manifested disrupted sociality despair levels rescued fluoxetine behavioral changes corresponded morphological molecular changes bla neurons including chronic stress elicited increases arborization dendritic length spine density bla principal neurons molecular level calcium permeable alpha amino hydroxy methyl isoxazolepropionic acid receptors ampars within synaptosome exhibited increased glur glur subunit ratio also observed increased glur phosphorylation ser enhanced cyclic amp dependent protein kinase pica activity bla molecular changes reverted basal state post treatment fluoxetine expression synaptophysin syp postsynaptic density protein psd bla neuronal synapses also enhanced chronic stress reversed post treatment finally chronic stress provoked depressive behavior overcome local blockage ampars bla via stereotaxic injection iem chronic stress elicited depressive behavior may due hypertrophy bla neuronal dendrites increased pica dependent ampar levels bla neurons furthermore fluoxetine reverse chronic stress triggered cytoarchitectural functional changes bla neurons findings provide insights depression linked structural functional changes bla neurons elsevier inc rights reserved
output voltage inverting input voltage inverting amplifier circuit measured conducted disturbance injected power supply pin dpi measurement correlation output voltage inverting input voltage shown
paper presents optimal design electromagnetic vibration based generator using simulated annealing method optimally extract vibrational energy system vibrating specific frequency selected mass spring stiffness resonant vibration required relationship induced energy generator structure permanent magnet height diameter number turns wire diameter single air coil discussed also prototype vibration based electrical generator built tested via shaker excited resonance frequency input amplitude consequently results reveal design parameters permanent magnet height diameter number turns wire diameter play essential roles maximizing electrical power
background neonatal intensive care unit nicu stressful environment infants families healthcare team immediate need neonatal nurses embrace translate new national perinatal association recommendations psychosocial support nicu parents clinical practice demonstrate best practices infants families whole team purpose summarize current evidence based practice recommendations provide suggestions team members develop strategies adopt implement quality improvement projects methods literature reviews conducted original national perinatal association workgroup teams covered levels available evidence qualitative quantitative clinical research guidelines clinical parental expertise evidence synthesized formulate set recommendations published december describe applicability vital role neonatal nurses elucidating projects track measurements change translate recommendations practice results neonatal nurses ideal position transform systems support nicu parents adoption recommendations bedside identify areas enhance implementation implications practice neonatal nurses integral problem solving identifying strategies translating recommendations nicu clinical practice improve parent psychosocial support implications research article disseminates evidence encourages scientific investigation various methods supporting emotional health nicu parents create better health outcomes
aspergillus fumigatus versatile fungus able successfully exploit diverse environments mammalian lungs agricultural waste products among many fitness attributes dozens genetic loci containing biosynthetic gene clusters bgcs producing bioactive small molecules often referred secondary metabolites natural products provide growth advantages fungus dependent environment summarize current knowledge bgcs named product expression profiles vivo bgcs may enhance virulence opportunistic human pathogen furthermore find extensive evidence presence many bgcs similar bgcs distantly related genera including emerging pathogen pseudogymnoascus destructans causative agent white nose syndrome bats suggest bgcs may predictive pathogenic potential fungi article part themed issue tackling emerging fungal threats animal health food security ecosystem resilience
clinical recommendations limit menopausal hormone therapy years yet impact shorter treatment duration cardiovascular health unknown hypothesized short long term estradiol treatment exerts positive lasting effects blood pressure vascular reactivity renal health study designed mimic midlife menopause followed treatment either followed exceeded current clinical recommendations female long evans retired breeders ovariectomized ovx age randomized three groups day vehicle veh veh day vehicle veh comparison veh veh veh groups lower systolic blood pressure enhanced mesenteric relaxation response estrogen receptor alpha stimulation despite reduced blood pressure induced renal cardiac hypertrophy reduced glomerular filtration increased proteinuria interestingly kidneys veh rats significantly fewer tubular casts groups conclusion long term lowered blood pressure exerted detrimental effects kidney health midlife ovx long evans rats whereas short term lowered blood pressure reduced renal damage findings highlight duration hormone therapy may important factor renal health aging postmenopausal women
recent years survivability aircraft put task ever one main reasons increase usage infrared guided anti aircraft missiles especially due availability man portable air defence system manpads terrorist groups thus aircraft signatures gaining importance compared radar visual acoustic signatures exhaust plume ejected aircraft one important sources signature military aircraft use low bypass turbofan engines propulsion focus present work modelling spectral radiation emission exhaust jet typical military aircraft evaluate aircraft susceptibility terms aircraft lock range due plume emission simple case typical surface air missile sam signature due aircraft plume examined holistic manner comprehensive methodology computing signatures affect aircraft lock range elaborated commercial cfd software used predict plume thermo physical properties subsequently house developed code used evaluating radiation emitted plume lowtran code used modeling atmospheric characteristics results obtained models reasonable agreement available experimental data analysis carried paper succinctly brings intricacy radiation emitted various gaseous species plume role atmospheric transmissivity dictating plume signature perceived guided sam
purpose purpose paper examine psychometric properties champion health belief model scales cervical cancer screening among women living hiv methods secondary data analysis conducted using data exploratory cross sectional study convenience sample women living hiv receiving care two hiv ambulatory care clinics florida item adaptation champion health belief model scales administered via paper pencil results authors used internal consistency measures confirmatory factor analysis ordinal item response theory irt techniques examine psychometric properties instrument item instrument adequate internal consistency factor structure however irt analyses suggested instrument could reduced items without loss relevant information conclusion shortened item instrument demonstrated good internal consistency among women living hiv future work include validating properties reduced instrument diverse samples patients conditions elsevier inc rights reserved
carbon nanotubes cnts graphene known good conductive fillers due favorable electrical properties high aspect ratios investigated application stretchable composite conductors stretchable conducting nanocomposite small fraction conductive filler material maintain stretchability demonstrate enhanced electrical networks nanocomposites via use cnt graphene hybrid system using small mass fraction conductive filler cnt graphene hybrid system exhibits synergistic effects prevent agglomeration cnts graphene restacking reduce contact resistance formation cnt graphene interconnection effects resulted nanocomposite materials formed multiwalled carbon nanotubes mwcnts thermally reduced graphene trg polydirnethylsiloxane pdms higher electrical conductivity compared mwcnt pdms trg pdms nanocomposites specific fraction sufficient form electrical network among conductive fillers nanocomposite materials maintained electrical conductivity strained
background study performed determine effectiveness patellofemoral bracing treatment patellofemoral osteoarthritis influenced patellofemoral joint alignment trochlear morphology hypothesized extreme patellar malalignment would benefit bracing methods thirty eight patients received bracing part comprehensive treatment plan patellofemoral osteoarthritis selected study ten measures patellar alignment taken rays alignment measures divided percentile groups tertiles contingency table analysis treatment outcome measured western ontario macmasters universities osteoarthritis index womac scores dichotomised two groups according improved improved according minimum clinically important difference mcid spearman rho test performed continuous variables fisher exact test performed correlation tertile groups mcid categories results thirty eight patients male female ages included study womac scores ranged mean change patients falling improved group global pain function scores respectively found non significant trend shown correlation coefficient bisect offset change womac global indicating trend higher change womac scores increasing bisect offset statistically significant correlations found mean mcid categories womac global function groups analysed percentile groups bisect offset patellar subluxation distance indicating higher percentile groups likely improve six months conclusion higher bisect offset patellar subluxation distance measures associated poorer outcomes however due limited sample size studies required fully examine relationship
need store query set strings string dictionary arises many kinds applications classically string dictionaries accounted small share total space budget natural language processing indexing text collections recent applications web engines semantic web rdf graphs bioinformatics many others handle large string dictionaries whose size significant fraction whole data cases string dictionary management scalability issue paper focuses problem managing large static string dictionaries compressed main memory space revisit classical solutions string dictionaries like hashing tries front coding improve using compression techniques also introduce novel string dictionary representations built top recent advances succinct data structures full text indexes structures empirically compared heterogeneous testbed formed real world string dictionaries show compressed representations may use little original dictionary size supporting lookup operations within microseconds numbers outperform state art space time tradeoffs many cases furthermore enhance representations provide prefix substring based searches also perform competitively results show compressed string dictionaries useful building block various data intensive applications different domains elsevier ltd rights reserved
background assess relationship hours sunlight railway suicide attempts days attempts methods railway suicide attempts causing railway suspensions delays min used linear probability model assess relationship study conducted tokyo kanagawa osaka prefectures japan data collected railway delay incident database japanese railway technical research institute public weather database japan meteorological agency results railway suicides attempts occurred tokyo kanagawa osaka less sunlight days leading railway suicide attempts associated higher proportion attempts sunlight days attempt similar trend difference found sunlight hours clays median iqr without median iqr railway suicide attempts evening finally apparent correlation railway suicide attempts monthly average sunlight hours attempted month month limitations railway suicides main suicidal methods japan conclusions observed increased proportion railway suicide attempts several days without sunlight light exposure blue light bright white light trains may useful reducing railway suicides especially consecutive days without sunshine forecasted elsevier rights reserved
reproductive coercion behavior interferes woman autonomous reproductive decision making may take form birth control sabotage pregnancy coercion controlling outcome pregnancy perpetrators may partners partner family woman family article reviews literature reproductive coercion international settings review research studies findings presented prevalence type reproductive coercion associated factors specific tactics relationship intimate partner violence ipv domestic violence laws particularly implications women reproductive health findings highlight reproductive coercion subset ipv poorly understood especially international settings research needed protective factors interventions capitalize protective factors strategies women use resist reproductive coercion policy implications recommendations discussed particular attention issues related diverse social cultural environments
assembling simultaneously using different types distributed computing infrastructures dci like grids clouds increasingly common situation infrastructures characterized different attributes price performance trust greenness task scheduling problem becomes complex challenging paper present design fault tolerant trust aware scheduler allows execute bag tasks applications elastic hybrid dci following user defined scheduling strategies approach named promethee scheduler combines pull based scheduler multi criteria promethee decision making algorithm multi criteria scheduling leads multiplication possible scheduling strategies propose soft methodology allows find optimal scheduling strategies given set application requirements validation method performed simulator fully implements promethee scheduler recreates hybrid dci environment including internet desktop grid cloud best effort grid based real failure traces set experiments shows promethee scheduler able maximize user satisfaction expressed accordingly three distinct criteria price expected completion time trust maximizing infrastructure useful employment resources owner point view finally present optimization bounds computation time promethee algorithm making realistic possible integration scheduler wide range resource management software elsevier rights reserved
unintended pregnancy important public health problem worldwide unwanted pregnancies may end induced abortion legal illegal safe unsafe childbirth many parts world life threatening even safe abortion distressing concerned unwanted births often lead poor health social outcomes mother child
second part article reports query essential characteristics effective engineering networks current business environments case studies focusing engineering design manufacturing engineering engineering services engineering networks four global leading companies studied refine enrich extend preliminary understandings gained first part article case studies suggested essential characteristics effective engineering networks four main areas including efficient engineering processes effective engineering learning flexible engineering resources digital engineering environment contributes theoretical understanding international engineering operations bridging missing link engineering network theories unique nature engineering expected findings help managers improve performance engineering networks facilitate effective interface management engineering functional areas
chronic kidney disease ckd important global public health problem associated adverse health outcomes high health care costs effective cost effective treatments available slowing progression ckd preventing complications including cardiovascular disease although wealthy nations highly structured schemes place support care people kidney failure less consideration given health systems policy much larger population people non dialysis dependent ckd integrate strategies national international initiatives control chronic noncommunicable diseases ncds merits attention synthesized various approaches ckd control across european countries present findings according key domains suggested world health organization framework ncd control report identifies opportunities strengthen ckd relevant health systems explores potential mechanisms capitalize opportunities across countries studied found number common barriers care people non dialysis dependent ckd limited work force capacity nearly complete absence mechanisms disease surveillance lack coordinated ckd care strategy poor integration ckd care ncd control initiatives low awareness significance ckd common challenges faced diverse health systems reflect need international cooperation strengthen health systems policies ckd care national kidney foundation inc
thyrotropin receptor tshr gene defined highly mutable gene mutations tshr gene result either gain loss receptor function subclinical hypothyroidism clinical condition defined elevated serum tsh level associated normal free thyroxine free triiodothyronine chronic autoimmune thyroiditis frequent cause subclinical hypothyroidism adults rare cases loss function mutation tshr cause present study novel tshr mutation confirmed loss function mutation identified year old chinese woman potential cause patient subclinical hypothyroidism case may provide valuable insight etiology
present research paper deals theoretical study numerical simulation control strategy wind energy conversion system wecs based doubly fed induction generator dfig stator directly connected grid rotor connected electrical network back back converter filter rotor side converter rsc controls power flow stator dfig grid controlling rotor currents dfig grid side converter gsc ensures regulation voltage desired value regulates power flow rotor dfig grid controlling filter currents standard current controllers used regulate gsc rsc output currents simulation results presented show effectiveness proposed control technique wind fluctuation
pumped storage unit psu difficult control compared conventional hydropower generation unit due frequent switching working conditions shaped characteristics pump turbine traditional proportional integral derivative pid controller typically easily provide high quality control overcome difficulties fractional order pid fopid controller designed psu study although fopid controller effective compared traditional pid controller complex optimize parameters controller pump turbine governing system ptgs thus gravitational search algorithm combined cauchy gaussian mutation named cggsa proposed used optimize fopid controller parameters experimental results indicate cggsa shown excellent optimization ability compared popular meta heuristics benchmark functions results also proved fopid cggsa controller shows significant advantages pid type controllers different optimization strategies meanwhile optimally designed controller shown great potential improve control quality ptgs multiple water heads elsevier inc rights reserved
seasonal affective disorder becoming widely recognised prevalent mood disorder adult population however studies investigated link sunlight exposure mood elderly referrals community mental health care older people mhcop hackney city area screened number patients referred depression three separate years order determine whether referrals made service darker months year october march lighter months year april september data three years combined found significant increase number referrals mhcop darker months chi squared value value tailed observed statistically significant seasonal pattern referrals suggests depression older people prevalent darker months year
aimsto determine degree observed benefit textquit accounted psychosocial mechanisms derived quit smoking messaging versus use extra programmatic smoking cessation treatments services designprospective multiple mediation model randomized controlled trial rct settingunited states nation wide participantsa total adult daily smokers participated participants average years age predominantly female white lacked college degree medium nicotine dependence average fagerstrom nicotine dependence score score half made previous quit attempt interventionadult daily smokers browsing web smoking cessation support recruited may july randomized receive smoking cessation support via textquit versus smoking cessation material measurementsmediators changes psychosocial constructs health behavior change use extra programmatic treatment assessed month using single item measures outcome self reported day point prevalence abstinence month follow findingsmediators accounted effect textquit smoking cessation psychosocial mechanisms complete mediational paths increases self efficacy quitting know sense someone cared partially explaining conferred benefit textquit use outside resources including treatments promoted explicitly textquit medication quitline treatments resources promoted textquit online forums self help materials complete mediational paths interaction effect existed medication use suggested participants using medication textquit conferred substantial benefit participants using medication conclusionstext messaging programs smoking cessation appear primarily confer benefit promoting improvements psychosocial processes related quitting rather use extra programmatic smoking cessation treatments services
thermo acoustic generators offer unique means converting thermal energy mechanical energy without moving parts without fluid circulation comparable stirling engine advantage much greater simplicity therefore natural candidates special uses interventions limited problem solve transforming mechanical energy electrical energy mhd generators offer excellent opportunities area particularly using mechanisms induction work concerns combination thermo acoustic generator induction generator new concept obtaining electric current adjustable voltage current strength delivered thermo acoustic wave frequency system subjected numerical simulation however experimental program studied collaboration industrial academic partners exploitation process using solar collector parabolic cylindrically parabolic envisaged aim produce electricity example isolate villages published elsevier ltd selection peer review responsibility name organizer
aim evaluate prevalence recurrent falls risk factors among older men living veterans homes taiwan methods cross sectional study enrolled residents participants received comprehensive geriatric assessment including barthel index mini mental status examination mmse geriatric depression scale questions gds mini nutrition assessment short form mna status urinary incontinence stool incontinence polypharmacy past history falls multimorbidity medication history results overall subjects mean age years males participated study whereas experienced falls past year recurrent fallers comparisons non fallers single fallers recurrent fallers disclosed significantly different following characteristics diabetes mellitus chronic kidney disease coronary artery disease charlson comorbidity index cci barthel index gds mna polypharmacy use hypnotics urinary incontinence stool incontinence trend multiple regression analysis identified gds significantly associated single falls recurrent falls single fallers recurrent fallers besides urinary incontinence independently associated recurrent fallers single fallers conclusion urinary incontinence depressive symptoms independent associated factors falls among older men living retirement communities however urinary incontinence associated recurrent falls single falls intervention study needed reduce recurrent falls management urinary incontinence elsevier rights reserved
security analysis attack defense modeling effective method identify vulnerabilities information systems proactive defense attack graph model reflects attack actions system state changes without considering perspective defenders assess network information system comprehensively show attack defense strategies cost defense graph model proposed compared attack graph model makes improvements defense graph mapped attack defense game model order provide basis active defense policy decision generation algorithm defense graph proposed representative example provided illustrate models generation algorithm
background prevailing perception family planning red flag islam deviant teachings quran hadith assam family planning among muslim particularly among non indigenous muslim inhabitant riverine areas quite unpopular usually poor uneducated various types misconceptions widely prevalent among following extensive awareness programme using different verses quran hadith muslims assam started participating birth control programme family planning myth among muslims assam
multi pump multi piston power take wave energy converter mppto wec proposed use novel renewable energy harvester termed ocean grazer mppto wec utilizes wave motion pump via buoys connected pistons working fluid within closed circuit store potential energy converted electricity via turbines paper introduces mechanical design model based performance prediction single piston pump constitutes basic building block mppto wec results provide preliminary validation aqueous lubrication viable means reducing friction wear suggesting water based hydraulic fluids prohibit solid contact piston cylinder interface reducing volumetric leakage allowing estimation energy extraction efficiency mechanical pumping system pending thorough extended tribological investigations using methodology introduced paper findings suggest overall system efficiency dictated hydrodynamics buoys actuating pumping system elsevier ltd rights reserved
study objective determine whether perioperative landiolol administration suppresses postoperative atrial fibrillation plasma cytokines elevation patients undergoing esophageal cancer surgery design prospective randomized controlled trial setting akita university hospital akita japan april january patients forty american society anesthesiologists grade patients undergoing elective esophagectomy interventions patients randomly divided two groups landiolol group landiolol min control group volume covered saline landiolol saline infused continuously induction anesthesia next morning measurements examined new onset sinus tachycardia measured plasma concentrations cytokines beta tnf alpha surgery end surgery next day days surgery data mean analyzed using two way anova followed bonferroni test post hoc comparison considered statistically significant main results demographic data similar landiolol control groups incidence significantly lower landiolol group compared control group well sinus tachycardia landiolol group control group plasma level end surgery significantly lower landiolol group compared control group plasma cytokines levels similar two groups entire study period conclusions perioperative landiolol administration suppressed incidence new onset well sinus tachycardia plasma elevation patients undergoing esophageal cancer surgery elsevier inc rights reserved
video game industry becoming increasingly important due revenues growing capabilities user experience important factor contributes acceptance video game usually assessed end development process reason difficult ensure adequate level interactive experience computer game players cancelation projects even bankruptcy company caused bad management paper propose game experience management gem method evaluate manage measure track early stages computer game development order compare proposal method comprised conventional approaches teams master degree students formed developing six tower defense games teaching basic multiplication operations surveys conducted compare games setting find games developed gem significantly improve increasing puppetry consequently reducing player frustration
background wildland fires cost billions dollars annually expose thousands firefighters variety occupational hazards little known injury patterns among wildland firefighters methods examined non fatal firefighter injuries among federal wildland firefighters reported department interior years risk disabling injury job assignment controlling demographic temporal variables assessed logistic regression results non fatal injuries slips trips falls frequent injury types sprains strains common injury engine crew workers suffered third injuries handcrews helitak smokejumper assignments increased odds sprains strains common injury overall conclusions injuries equally prevalent job assignment others vary identifying hazards leading injuries essential develop prevention strategies
background studies shown stress implicated cause neck pain objectives purpose study examine effect simple zero cost stress management program patients suffering methods study parallel type randomized clinical study people suffering chronic non specific chosen randomly participate eight week duration program stress management including diaphragmatic breathing progressive muscle relaxation intervention control condition self report measures used evaluation various variables beginning end eight week monitoring period descriptive inferential statistic methods used statistical analysis results end monitoring period intervention group showed statistically significant reduction stress anxiety report stress related symptoms percentage disability due intensity time daily routine satisfaction levels elevated statistically significant difference observed cortisol measurements conclusions stress management positive effects patients
background natural products made plant sources used variety cosmetic applications source nutrition whitening agent flowers cassia fistula family fabaceae used traditional medicine skin diseases wound healing reported possess anti oxidant properties anti aging effect fistula flower extract human skin fibroblast investigated methods butanolic extraction fistula flowers completed active compounds classified cytotoxicity fibroblasts evaluated srb assay purposes selecting non toxic doses experiments collagen hyaluronic acid synthesis measured using collagen kit elisa respectively moreover enzyme activity including collagenase matrixmelloproteinase mmp tyrosinase also evaluated results found flower extract affect skin fibroblast cell growth results show flower extract significantly increased collagen synthesis dose dependent manner flower extract also significantly inhibited collagenase mmp activity furthermore flower extract could inhibit tyrosinase activity causes hyperpigmentation induces skin aging conclusions fistula flower extract displayed preventive effect used anti aging purposes human skin fibroblasts may appropriate choice cosmetic products aim provide whitening effects designated anti aging facial skin care products
objective study develop conceptual model analyze role rice paddy fields water management use model suggest appropriate countermeasure land development rice paddy fields traditionally seen east south east asia particularly areas considerable seasonal variation rainfall resulting flooding drought one advantages fields east asia period rainfall similar period water demand rice paddy study water management functions rice paddy evaluated using rainfall storage discharge rsd modeling rsd system type onsite structure used rainwater management study area rice paddy assumed rice paddy considered perform storage catchment functions rainwater harvesting system rsd system used analyzing outflow rate according rice paddy area peak outflow curves year period effectiveness rsd system reducing final water discharge rate rice paddy evaluated
given continuous evolution hardware capabilities embedded systems idea virtualization becomes practical virtualization embedded systems provides running multiple types applications platform reduction hardware power consumption costs consolidation existing functionality present versatile virtualization framework vmxhal designed implemented deployed embedded systems ranging development boards fully fledged hand held devices vmxhal uses reduced trusted computing base lines code compared xen lines code comprising thin layer microkernel minimal set management applications thin layer design provides versatility allowing baremetal native applications paravirtualized operating systems proof concept built virtualized dual android setup two android operating systems running simultaneously galaxy nexus phone top virtualization framework
introduction neurological complications quite frequent patients solid organ transplantation presenting focal generalized neurologic symptoms well altered mental status posterior reversible encephalopathy syndrome rare cliniconeuroradiological entity characterized headache altered mental status cortical blindness seizures focal neurological signs diagnostic magnetic resonance imaging case report present case year old woman one episode seizures sudden onset altered mental status time person perception accompanied headache thirtieth postoperative day renal transplantation conclusion posterior reversible encephalopathy syndrome although uncommon post renal transplantation complication considered patients several factors surrounding setting transplantation implicated development thus physicians aware condition order establish diagnosis offer appropriate treatment
term smart grid refers modernization electrical network consisting integration various technologies dispersed generation dispatchable loads communication systems storage devices operates grid connected islanded modes result traditional optimization techniques new power systems seriously influenced last decade one important technical economical tools regard optimal power flow opf fundamental optimization tool operation planning fields opf undeniable role power system paper reviews compares opf approaches mainly related smart distribution grids work main opf approaches compared terms objective functions constraints methodologies furthermore computational performances case study networks publication date methods reported finally basic challenges arising new opf methodologies smart grids addressed
land surface albedo essential variable surface energy climate modeling describes proportion incident solar radiant flux reflected earth surface capture temporal variability spatial heterogeneity land surface satellite remote sensing must used monitor albedo accurately global scale however large data gaps caused cloud ephemeral snow slowed adoption satellite albedo products climate modeling community address needs community used number temporal spatial gap filling strategies improve spatial temporal coverage global land surface modis brdf albedo nbar products rigorous evaluation gap filled values shows good agreement original high quality data rmse nir band albedo red band albedo global snow free cloud free modis brdf albedo dataset established offers unique opportunities monitor assess impact changes earth land surface author published elsevier
article introduces novel way transforming linear second order systems first order state space models strictly dissipative realization property extends potential analysis large scale systems many ways allows application efficient methods solution lyapunov equations guaranteed preservation asymptotic stability model order reduction transformation easy implement applicable models high order due negligible computational effort
asthma chronic airway disease pathological mechanisms reversible airway obstruction bronchial hyper reactivity constriction lower airways supraventricular tachycardia svt common arrhythmia originates bundle causing heart rates exceeding beats min svt patients present palpitation chest pain chest discomfort dyspnea hyperventilation lightheadedness occasionally besides extraordinary presentations svt available literature report describe case patient presenting treatment resistant asthma like attacks lasting years suspected svt underlying etiology treated slow pathway radiofrequency ablation
parenting cognitive emotional behavioral endeavor yet limited research investigates parents executive functions emotion regulation predictors parents interact children current study multimethod investigation parental self regulation relation quality parenting behavior parent child interactions diverse sample parents kindergarten age children using path analyses tested parent executive functions inhibitory control lack emotion regulation strategies uniquely relate sensitive responsive behaviors positive collaborative behaviors observed interaction tasks analyses accounted parent education financial stress social support socioeconomic factors likely relate parent executive function emotion regulation skills diverse sample primary caregivers found direct assessment parent inhibitory control positively associated sensitive responsive behaviors whereas parent self reported difficulties using emotion regulation strategies associated lower levels positive collaborative dyadic behaviors parent education financial stress predicted inhibitory control social support predicted emotion regulation difficulties parent education also significant predictor sensitive responsive behaviors greater inhibitory control skills fewer difficulties identifying effective emotion regulation strategies significantly related final path model discuss findings context current emerging parenting interventions
glutamate essential excitatory neurotransmitter regulates brain functions activity tightly regulated glutamate transporters excess glutamate synaptic cleft dysfunction excitatory amino acid transporters shown involved development alzheimer disease precise regulatory mechanism poorly understood using aspartic acid uptake assay found beta oligomers impaired glutamate uptake astrocytes neurons astrocytes process accompanied reduced expression glt glast detected western blot immunocytofluorescence however mrna levels eaats detected qpcr astrocytes neurons altered suggests process post translational localization analysis using immunocytofluorescence showed ubiquitylation glt significantly increased therefore hypothesized beta oligomers induced endocytosis astrocytic glt may involved ubiquitylation addition beta oligomers enhanced secretion beta tnf alpha culture supernatant may correlated inflammatory response altered eaats expression function alzheimer disease findings support idea dysregulation glutamatergic system may play significant role pathogenesis alzheimer disease furthermore enhancing expression function eaats astrocytes neurons might new therapeutic approach treatment alzheimer disease elsevier ltd rights reserved
despite frequency individuals compare benchmark little research examined implications comparisons willingness help others comparisons vary direction suggesting one better benchmark downward comparison worse benchmark upward comparison argue find relatively better people making downward comparisons likely view giving means expressing altruistic values give back better person compared making upward comparisons consequently context highlights instrumentality giving altruistic reasons benefit others willing give making upward comparisons furthermore difference mitigated context highlights instrumentality giving benefit self reversed instrumentality giving benefitting others challenged obtain support account across four studies moderation mediation across monetary nonmonetary comparison domains society consumer psychology published elsevier inc rights reserved
introduction proceedings sharing overview presentations given part skin academy symposium held barcelona spain april skin academy international interdisciplinary dermatology initiative created contribute growth scientific knowledge dealing skin diseases year meeting aimed build bridges latest research everyday clinical practice providing dermatologists important updates common skin diseases well current hot topics
paper presents low power low noise high precision operational amplifier tracking system containing intelligent medical device extended version paper previously published nenadovic proc icecs accuracy tracking system strongly depends accurate amplitude acquisition received signal therefore operational amplifier precise gain control effective temperature compensation designed fabricated operational amplifier provides linear temperature independent signal amplification frequencies khz body temperature amplifier shows measured gain temperature sensitivity low ppm degrees temperature range degrees consumes supply voltage furthermore measured gain temperature sensitivity range degrees ppm degrees simulated linearity signal amplitudes input referred noise khz aehz open loop gain khz bandwidth gain product mhz measured operational amplifier designed ihps sige bicmos technology occupies area
background objective genus salacia celastraceae woody climbing medicinal plant consisting species many endangered species located throughout world tropical areas various parts plant food functional food additive tea extensively used treat variety ailments like diabetes obesity well inflammatory skin diseases present work reviews phytochemical properties pharmacological activities biotechnological strategy conservation safety evaluation valuable genus results conclusion efforts needed isolate new phytoconstituents important medicinal plant mechanism anti diabetic action done molecular cellular levels thus fundamental biological understanding required future applications though safety plant species well documented confirmed many toxicological studies toxicity research clinical trials recommended order sustain harvest conservation agronomic practices cultivation developed establishment efficient protocols vitro propagation necessary approaches like genetic manipulation hairy root culture media standardization use inducers precursors elevation secondary metabolite levels could also attractive
water permeability one important functional characteristics geotextiles mandatorily marked factsheets type trademark geotextile feature found standards denomination flow mathematical modeling water permeability geotextiles examines influence technological parameter quality using graphics may achieve purpose paper considered technological parameters interweaving density depth penetration independent variables huge influence quality analyzed geotextiles
explore modern telescopes equipped larger diameter mirror owing deadweight external force difficult maintain position attitude primary mirror mirror cell hydraulic supporting system optional choice solve problem requires high quality hydraulic oil efficient oil filling paper influence gas content oil bulk modulus discussed oil preconditioning filling machine designed detected using oil particle size detecting instrument preconditioning result shows decreases obviously oiling filling operation also carried primary mirror test rig
one important prerequisites efficient design optimization microwave structures availability fast yet reliable replacement models surrogates multiple evaluations structure hand executed reasonable timeframe direct utilization full wave electromagnetic simulations handling optimization related tasks often prohibitive popular approach construction fast surrogates data driven modeling unfortunately normally requires large number training samples virtually infeasible structures exhibit highly nonlinear responses filters couplers work design oriented modeling technique proposed good accuracy achieved careful non uniform design space sampling accounts nonlinear relationship operating frequency structure geometry parameters well carrying modeling process selected characteristic points structure responses determine satisfaction violation given design specifications approach demonstrated using miniaturized microstrip rat race coupler modeled wide range geometry parameters compared conventional data driven modeling using kriging interpolation design optimization examples also provided copyright john wiley sons ltd
paper shown quantitative qualitative changes drinking water distribution system occurring urban locality inhabitants water consumption past decade reduced relation consumer debts highlighted oscillations related water pressure system residual chlorine concentration pressure zones hydraulic modeling water distribution system performed using computer programming software epanet type program performs hydraulic simulations water quality pressure pipeline network analyzing interpreting results hydraulic simulations performed different operational situations consumption resulted areas residual chlorine levels fall well limits imposed laws regulations force situation required corrective measures water quality reducing eliminating water stagnation increasing velocity water circulation pipe sections affected book useful units operators use water networks areas significant debt fluctuations reducing travel speeds sections pipeline areas residual chlorine drops limits favoring formation ecosystems biological thereby triggering internal processes auto pollution reflected degradation water supplied consumers
paper presents theoretical background implementation details multi domain symbolic analysis program developed emphasis linearized hybrid systems combining classical electrical circuits controllers electro mechanical converters mechanical parts electric drives systems analyzed composed basic elements complex behavioral blocks regulators converters drives etc models defined easily extensible library implemented algorithms equation matrix based symbolic simplification allow obtaining symbolic expressions acceptable complexity even larger systems
background several risk factors associated multiple sclerosis progression may amenable intervention objective systematically review evidence interventions targeting risk factors progression methods searched six databases existing reviews till march consulted experts identify randomized controlled trials rcts interventions targeting risk factors prospero crd results total rcts met inclusion criteria expanded disability status scale edss scores exercise interventions differ compared untreated controls standardized mean differences smds confidence interval seven rcts low quality evidence qoe dietary interventions show statistically significant effect relative risk progression four rcts moderate qoe compared placebo edss scores vitamin supplementation significantly different placebo smd five rcts low qoe conclusion identify risk factor interventions significant effects progression overall qoe limited adequately powered trials needed vitamin supplementation long term exercise smoking cessation
quantitative interpretation large scale controlled source electromagnetic csem data frequency domain requires efficient stable three dimensional forward modeling inversion codes paper present forward modeling scheme frequency domain csem surveys based mimetic finite volume mfv method solves helmholtz equation total electric field important step modeling scheme solve large linear equation system resulting mfv discretization order obtain stable accurate numerical solutions linear equation system solved direct matrix solver namely mumps robust commonly used iterative solvers krylov subspace iterative techniques numerically difficult cases algorithm suitable multi source csem modeling separating solving process single expensive matrix factorization relatively inexpensive forward backward substitutions many right hand sides total field formulation dense gridding vicinity source points usually required mitigate source singularities extra padding cells boundaries needed meet boundary conditions quickly increase size linear equation system solved making computationally expensive direct solutions avoid substantial increase size discretized model source correction technique applied reduce source singularities boundary effects addition considering independence computation different frequencies parallel forward modeling scheme based frequency partition implemented speed simulation multi frequency csem problems numerical experiments carried evaluate performance forward modeling algorithm numerical solutions using algorithm show good agreement quasi analytic solutions layered models numerical errors significantly reduced source correction vicinity source points addition comparison simulated data generated algorithm published data typical marine model validates algorithm besides statistical results demonstrate parallel computing based simple frequency partition approach achieve nearly linear speedup due independence computation frequencies multi frequency csem simulation
power quality disturbances becoming increasingly important concerns network operators customers delivery power voltage dip one disturbances caused different factors mainly unpredictable faults occurring different parts electrical network dips originating parts network may propagate parts network causing huge financial losses industrial commercial customers knowing maximal fault impedance beyond dips detected monitoring equipment helpful grid operator paper mainly focuses influence critical impedance distance measured point common coupling pcc main busbar next ilv transformer fault point monitoring dips typical dutch network analyzed mathematical models developed different fault types taking different grounding techniques account simulations performed using matlab industrial customers connected pcc critical distances corresponding fault types evaluated compared based computer simulations dips missed monitoring device placed appropriate location thoroughly discussed influence different system groundings phase line voltage dips also explained paper moreover transfer dips network impact critical distance fault transfer dips briefly explained
nocturnal rodents play key role sonoran desert ecosystem consumers prey reservoirs disease yet rodent distribution remains poorly mapped use surface temperature extracted landsat thematic mapper thermal infrared band model rodent abundance obtained trapping data organ pipe cactus national monument southwest arizona produce response curves describe effects surface temperature species abundance daytime surface temperature derived images collected june across thirty rodent trapping grids ranged degrees degrees results show peak seasonal surface temperature splits high species abundances two groups merriam kangaroo rat arizona pocket mouse desert pocket mouse southern grasshopper mouse species prefer habitat characterized higher surface temperatures white throated wood rat cactus mouse rock pocket mouse bailey pocket mouse species prefer habitat characterized lower temperatures abundances high low temperature habitat groupings correlate linearly surface temperature respectively surface temperature integrates multiple landscape characteristics topography vegetation cover soil properties define dominant habitats orpi rodents results prove simple models inform complex ecological processes elsevier ltd rights reserved
blow solutions purely elliptic generalized davey stewartson system studied using relaxation numerical method numerical method based implicit finite difference scheme second order accuracy time space stability numerical method analyzed investigating linear stability plane wave solutions evaluate ability relaxation method detect blow numerical simulations conducted several test problems particular attention paid gap interval neither global existence blow result established monotonicity properties blow time coupling parameter also investigated numerically elsevier rights reserved
centers medicaid medicare services cms created novel payment program create incentives physician focus quality care measures report quality performance first time initially termed physician voluntary reporting program various congressional actions including tax relief health care act trhca medicare improvements patients providers act mippa strengthened ensconced program eventually leading quality program termed today physician quality reporting system pqrs result passage affordable care act pqrs program expanded include traditional pqrs reporting program newer value modifier program first time programs designed include pay performance incentives physicians providing care medicare beneficiaries measure cost care recent passage medicare access children health insurance program chip reauthorization act march includes changes payment programs even profound impact emergency care providers describe implications important federal policy changes emergency physicians
detecting different categories objects image video content one fundamental tasks computer vision research pedestrian detection hot research topic several applications including robotics surveillance automotive safety address problem detecting pedestrians surveillance videos paper present new feature extraction method based multi scale center symmetric local binary pattern operator modules foreground segmentation feature pyramid training occlusion handling proposed method introduced details design implementation experiments caviar sequences show presented system detect pedestrians real time effectively accurately surveillance videos
soil moisture distributions high spatio temporal resolution scarce beneficial understanding ecohydrological processes closing water cycle basin scale sensor networks innovative ability capture spatio temporal heterogeneity dynamics soil moisture however used directly derive spatially continuous soil moisture distributions bayesian based upscaling algorithm utilizes modis derived apparent thermal inertia used map daily soil moisture spatial patterns resolution babao river basin china soil moisture observations seven automatic meteorological stations located different elevation zones employed validate mapping algorithm correlation coefficient unbiased root mean square error rmse averaged respectively indicate satisfactory estimation accuracy resolution soil moisture products sampled resolution compared level soil moisture ocean salinity mission smos soil moisture product results show products exhibit strong temporal consistency however due complex topography smos soil moisture generally lower upscaling results semivariograms empirical orthogonal function eof analysis used analyze space time heterogeneities soil moisture scale summer rainfall results soil moisture low spatial variability complex spatial structure rainy season spatial heterogeneity soil moisture affected factors soil texture evapotranspiration topography perspective temporal variation upscaled soil moisture shows well defined seasonal cycle represents effects decreased rainfall august october rain falls summer due mountain microclimate oscillation soil moisture pronounced area compared regions based validation analysis mapping results upscaling method proven feasible upscaled soil moisture used analyze eco hydrological processes validate remote sensing products elsevier inc rights reserved
article presents new topology implementing electronically tunable bandpass filter using current feedback operational amplifier electronic tuning center frequency proposed circuit achieved using externally connected voltage amplifier feedback path without disturbing constituents filter shadow filter proposed circuit used developing undergraduate experiment illustrates operation bandpass filter electronic control center frequency using concept shadow filter experimental results obtained using current feedback operational amplifier included
paravirtualization page table management components guest operating systems properly patched security guarantees hypervisor however none pay enough attention performance improvements results two noticeable performance issues first security patches exacerbate problem execution paths guest page table allocations become extremely long would consequently increase latencies process creations exits second patches introduce many additional iotlb flushes leading extra iotlb misses misses would negative impacts performance peripheral devices paper propose pibooster novel lightweight approach improving performance page table management first pibooster shortens execution paths page table allocations pibooster cache maintains dedicated buffers serving page table allocations second pibooster eliminates additional iotlb misses fine grained validation scheme performs guest dma validations separately instead together implement prototype xen linux guest kernel also evaluate performance effects pibooster firstly pibooster able completely eliminate additional iotlb flushes workload stable environments effectively reduces allocation time page table average expectedly latencies process creations exits reduced average besides specint netperf lmbench results indicate pibooster negative performance impacts cpu computation network disk
compensate limitations optical remote sensing restricted cloud cover worth exploring detect cyanobacterial blooms using synthetic aperture radar sar penetrate clouds satellite ground synchronous experiment conducted lake taihu third largest freshwater lake china lipopeptide biosurfactant detected algal scum layer average content viscosity mpa scum significantly higher scum free water surface tension algal scum decreased sar microwave backscatter reduced indicated cyanobacterial scum could effectively attenuate capillary waves appear dark patches sar images sar potential developed tool remote sensing algal scum lake waters society photo optical instrumentation engineers spie
main aim paper develop four innovative linearization formulas nonsymmetric jacobi polynomials means find coefficients products jacobi polynomials certain parameters general coefficients expressed terms certain hypergeometric functions unit argument employ symbolic algebraic computations algorithms zeilberger petkovsek van hoeij reducing coefficients moreover based certain whipple transformation two new closed formulas summing certain terminating hypergeometric functions unit argument deduced new formulas definite integrals given aid derived linearization formulas
aimed precisely estimate intra tumoral heterogeneity using spatially regularized spectral clustering srsc multiparametric mri data compare efficacy srsc previously reported segmentation techniques mri studies six nmri mice bearing subcutaneous human glioblastoma tumors scanned using dedicated small animal magnetic resonance imaging mri scanner data consisted weighted images apparent diffusion coefficient maps pre post contrast maps following scan tumors excised thin slices parallel axial field view processed histological staining mri data segmented using srsc means fuzzy means gaussian mixture modeling estimate fractional population necrotic peri necrotic viable regions validated fractional population obtained histology aforementioned methods overestimated peri necrotic underestimated viable fractions srsc accurately predicted fractional population three tumor tissue types exhibited strong correlations necrotic peri necrotic viable histology precise identification necrotic peri necrotic viable areas using srsc may greatly assist cancer treatment planning add new dimension mri guided tumor biopsy procedures
article presents results changes urban construction land driving forces urban agglomerations china first urban construction land areas urban construction land areas per ten thousand persons compared jing jin urban agglomeration yangtze river delta urban agglomeration pearl river delta urban agglomeration second dynamic degree model used express changes urban construction land areas different periods present spatial traits changes using geography information system software furthermore cointegrated relationship analysis granger causality test adopted analyze correlation urban construction land area influential factors conclusions periodicity urban construction land area increase three urban agglomerations obvious rate increase higher three urban agglomerations difference dynamic degree significant among different periods dynamic degrees largest beginning total period obvious difference urban distribution higher dynamic degree urban agglomeration three urban agglomerations displayed highly significant correlations urban construction land area influential factors significant differences factor distribution influential direction granger causality certain probability relationship granger causality lag obvious lag
integration solar thermal energy coal fired power station promising technology many coal dependent countries work investigated design performance dual heat source boiler power generation system level modelling approach example study heat solar power tower spt integrated supercritical coal fired power unit two integration schemes considered system level analytical model established coupled transient process heliostat field one tank thermocline thermal energy storage design performance hybrid system one typical year analyzed accordingly results revealed importance seasonal variation direct normal insolation dni thermal energy storage scheme integration methodology quality sunshine amount sun flux could influence solar power efficiency increase storage volume could decrease discharging efficiency maximum capacity dni increasing storage capacity could improve efficiency either integration scheme coal consumption could economized least ton per year maximum solar efficiency scheme solar energy used heat superheat steam could reach also came penalty reduced efficiency thermal receiver minimum storage capacity solar efficiency scheme changed scheme change elsevier ltd rights reserved
influence sleep memory long history sleep role formation false memories less clear moreover virtually nothing known development false memories beyond delays first time assess post sleep development true false memories across longer delay intervals although technically false memory remembering information related theme gist experience considered adaptive process evidence suggests sleep compared wake period increases true gist based false memories deese roediger mcdermott drm task studies returned result studies rule possibility sleep merely protecting information interference opposed actively aiding consolidation equate amount time spent awake asleep across groups assess positioning sleep relative memory encoding impacts retention across longer delays participants encoded drm lists morning wake groups evening sleep groups tested either later time day results demonstrate true memory better participants sleep soon learning sleeping first also increased false memory low performers importantly similar previous studies found negative correlation slow wave sleep sws false memory suggesting sws may detrimental semantic gist processing elsevier inc rights reserved
urban water pollution becomes increasingly serious sewage treatment process becomes much complicated highly complex sewage treatment projects challenge traditional design construction management mode based parameterization visualization simulation collaboration characteristics bim technology paper used core softwares bim building sewage treatment structure models explore suitable way modeling based building information model imported schedule information form model carrying construction simulation model studied application bim technology construction management sewage treatment project
david stoesz offers sweeping critique children bureau social work education claiming existence child welfare cartel also attacks quality social work education research claims poorly invested government funding helped create unmitigated failures american child welfare system however closer examination reveals many claims dramatic actually ill conceived unsupportable attempt clarify inform readers significant aspects field child welfare contemporary responses made federal government partnership social work educators researchers
patterns care following topical testosterone agent tta initiation poorly understood study aimed characterize care following tta initiation compare results patients without serum testosterone assay within days including tta initiation adult men initiating ttas january march identified commercially insured database patients included initiated recommended starting dose rsd months continuous eligibility preinitiation baseline postinitiation study period respectively patients stratified preinitiation assay maintenance dose attainment month determined using unadjusted generalized estimating equations regression compare dose relative rsd month month outcomes included maintenance dose attainment month time stopping index tta refills claim nonindex testosterone replacement therapy trt proportion patients study period assay diagnosis hypogonadism another low testosterone condition compared using chi square wilcoxon rank sum tests categorical continuous variables respectively maintenance dose attained month postinitiation rsd approximately patients preinitiation assay men likely receive diagnosis another low testosterone condition follow assay continue treatment filling nonindex trt less likely stop refilling treatment index tta differences care following tta initiation suggest preinitiation assays guideline based care may helpful ensuring treatment benefits
background aim study reversible cerebral vasoconstriction syndrome rcvs characterized severe thunderclap headache without associated neurological symptoms neuroimaging findings reversible vasoconstriction cerebral arteries puerperium recognized precipitant incidence puerperal rcvs unknown conducted prospective study assess incidence risk factors clinical features rcvs material method nine hundred consecutive puerperae prospectively enrolled within three days delivery past medical history basal demographic anthropometric biological variables recorded trans cranial colour coded sonography tccs performed assess early signs vasospasm brain vessels structured telephone interview planned subjects one month postdelivery results thunderclap headache recorded subjects first visit one month follow interview patients reported least one episode thunderclap headache patients course spontaneously benign one patient presented emergency ward throbbing thunderclap headache three weeks delivery diagnostic work ended diagnosis rcvs outcome favourable conclusion normally coursing pregnancies uncomplicated delivery risk puerperal rcvs negligible way thunderclap headache may occur measurable proportion although vast majority cases benign course transcranial doppler sonography may helpful pick cases neuroradiological investigation warranted elsevier rights reserved
growing electricity demand range sources changes power grid structures open possibility frequent much higher fault current traditional solutions fault difficult satisfy requirement new power grid due many factors high cost additional impact power grid normal loading condition leads research efficient alternative solution interest academia industry superconducting fault current limiter sfcl paper two types low inductance solenoidal coils braid type nonintersecting type built high temperature superconductors current limiting performance recovery characteristics losses types coils tested compared detail experimental results show types coils effectively limit fault current recover several seconds furthermore comparison losses types sfcls shows loss braid type coil lower single tape order magnitude low current regions
deep learning thing tomorrow causing complete drift shallow architecture deep architecture estimate shows computers learning rather processing deep learning fast growing effects area pattern recognition computer vision speech recognition feature extraction language processing bioinformatics statistical classification make system learn deep learning makes use wide horizon machine learning algorithms gene expression data uncertain imprecise paper discuss supervised unsupervised algorithms applied gene expression dataset intermediate algorithms classified semi supervised self taught also play important role improve prediction accuracy diagnosis cancer discuss deep learning algorithms provide better analysis hidden patterns dataset thus improving prediction accuracy
era antiretroviral therapy people living hiv aids live longer subject morbidities affect general population chronic kidney disease increasing number people living hiv aids end stage renal disease candidates renal transplantation prior experience demonstrated hiv positive renal transplant recipients acceptable survival graft survival decreased rejection rates increased possibly due suboptimal management immunosuppressive medications face drug interactions antiretroviral therapy particularly protease inhibitors non nucleoside reverse transcriptase inhibitors integrase strand transferase inhibitors advantageous since avoid drug drug interactions immunosuppressive drugs calcineurin inhibitors report clinical outcomes hiv positive patients underwent kidney transplantations institution cumulative survival one year three year survival integrase strand transferase inhibitor based regimens used nine patients eight survived patients integrase strand transferase inhibitor graft survival two allograft rejection contrast graft failure occurred three patients non integrase strand transferase inhibitor based regimens based study findings previously published data conclude integrase strand transferase inhibitor based therapy preferably instituted prior transplantation preferred antiretroviral regimen hiv positive renal transplantation
oxytocin reduces amygdala responses threatening social stimuli males suggested facilitate approach related processing either decreasing anxiety intensifying salience current administration study tested whether oxytocin either reduces enhances amygdala responses threat approach placebo controlled randomized double blind subjects design healthy males undergoing fmri social approach avoidance task oxytocin decreased amygdala activation threat approach threat avoidance neural effect supports oxytocin social anxiolytic effects provides neuroendocrine mechanism promoting social approach findings may yield clinical implications individuals suffering dysregulations social approach patients anxiety disorders elsevier ltd rights reserved
despite decades research humans biological mechanisms motivate individual help others remain poorly understood order investigate roots pro sociality mammals established helping behavior test paradigm rats faced conspecific trapped restrainer opened outside course repeated test sessions rats exposed trapped cagemate learn open door restrainer thereby helping trapped rat escape ben ami bartal discovery natural behavior provides unique opportunity probe motivation rodent helping behavior leading deeper understanding biological influences human pro sociality determine affective response motivates door opening rats receiving midazolam benzodiazepine anxiolytic tested helping behavior test midazolam treated rats showed less helping behavior saline treated rats rats receiving injection yet midazolam treated rats opened restrainer containing chocolate highlighting socially specific effects anxiolytic determine midazolam interferes helping sympatholytic effect peripherally restricted beta adrenergic receptor antagonist nadolol administered nadolol interfere helping corticosterone response rats exposed trapped cagemate measured compared rats subsequent helping behavior rats greatest corticosterone responses showed least helping behavior smallest responses showed consistent helping shortest latency results discussed terms implications interaction stress pro social behavior finally observed door opening appeared reinforcing novel analytical tool designed interrogate pattern door opening signs rat behavior one session influenced behavior next session results suggest helping trapped rat greater motivational value chocolate sum series experiments clearly demonstrates fundamental role affect motivating pro social behavior rodents need helper resonate affect victim
hepatocellular carcinoma hcc invasive form hepatic cancer arising accumulation multiple genetic alterations study causal role disturbed canonical wnt beta catenin pathway approved hcc driven important gene candidates determined micrornas mirnas small non coding rnas key regulators important cancer genes participation tumorigenesis shown reviewing literature wnt gene functional significance selected approve mirnas new subjects targeted therapy proper fast mirna detection also confirmation role bioinformatics obtaining practical data benefited different bioinformatics tools targetscan miranda diana order use hcc model used hepg cell line luciferase assay applied assess ability selected mirnas targeting wnt utr overexpress selected mirna hepg cell line viral construct prepared quantitative real time pcr performed evaluate selected mirna target gene expression levels mir selected according data concerning various bioinformatics tools mir downregulated wnt gene expression upregulated hepg cell line viral construct transduction mir expression elevated wnt expression notably declined finally introduced wnt gene one important genes hcc also showed mir regulate wnt gene expression moreover study determines potential bioinformatics analyses providing accurate reliable data mirna messenger rna mrna prediction
paper present pmorsya new parallel software package symmetric sparse matrix ordering shared memory systems complete fill minimization problem solved means multilevel nested dissection algorithm modifications vertex separators parallel processing done task based fashion granularity tuning employ threading techniques shared memory using openmp technology opposed message passing interface based approach widely used parallel sparse matrix ordering experimental results symmetric matrices university florida sparse matrix collection matrices finite element analysis three dimensional strength problems show implementation competitive parmetis scotch libraries ordering quality performance pmorsy library publicly available lobachevsky state university supercomputing center web site
humans laboratory animals suffering cerebellar lesions exhibit cognitive well many emotional behavioral abnormalities latter already observed cerebellar mutant mice currently used highlight aspect autism spectrum disorders aim study investigate influence cerebellar related stress response abnormalities spatial learning memory cerebellar deficient lurcher mutant mice exposed water environment without active escape possibility tested spatial learning morris water maze marker stress intensity measured corticosterone urine finally volumes individual components adrenal gland estimated though spatial navigation deficit water maze lurcher mice preserved substantial residuum learning capacity lurcher mutants higher increase corticosterone level exposure water environment wild type mice observe decrease physiological stress marker start end spatial navigation task despite significant improvement behavioral performances furthermore zona fasciculata zona reticularis adrenal cortex well adrenal medulla larger lurcher mice reflecting high stress reactivity conclude genotypes water exposure strong stressor habituation experiment independently increasing controllability stressor ability find escape platform based findings suggest enhanced stress response water exposure main factor explaining spatial deficits cerebellar mutant mice elsevier inc rights reserved
eastern hognose snake heterodon platirhinos species conservation concern especially northeastern portion range remain relatively common cape cod national seashore barnstable county massachusetts usa studied spatial ecology habitat selection radio tracked adult snakes may november yielding relocations conducted use availability analysis investigate patterns microhabitat selection using subset snake locations conducted compositional analysis habitat selection multiple spatial scales within home ranges using high resolution pixel size vegetation cover map study area snakes moved frequently large home ranges relative snake species similar body size exhibited variation home range size among individuals movements peaked different times year sex different sexes fall gravid females movement significantly greater week post oviposition period versus week pre oviposition period estimates home range average daily movements day lower estimates studies eastern hognose snakes possibly greater density resources study area probability snake habitat use increased grass leaf litter decreased open soil compositional analysis revealed strong avoidance open dune areas comparison edge density use random locations within home ranges revealed apparent preference edge habitat recommend resource managers limit recreational disturbance maintain patchy mosaic early successional vegetation abundant edge ensure persistence appropriate habitat species identified timing peak seasonal movements recommend information used help prevent road mortality important population wildlife society
presence micropollutants environment triggered research quantifying predicting fate wastewater treatment plants wwtps since removal micropollutants highly related conventional pollutant removal affected hydraulics aeration biomass composition solids concentration fate conventional pollutants characteristics must well predicted tackling models predict fate micropollutants light current paper presents dynamic modelling conventional pollutants undergoing activated sludge treatment using limited set additional daily composite data besides routine data collected wwtp one year results showed basis modelling removal micropollutants burger diehl settler model found capture actual effluent total suspended solids tss concentrations efficiently takacs model explicitly modelling overflow boundary results also demonstrated particular attention must given characterizing incoming tss obtain representative solids balance presence chemically enhanced primary treatment key predict fate micropollutants
purpose evaluate effect posture repetition filling cystometry urodynamic parameters materials methods seventy one men benign prostatic hyperplasia participated urodynamic study september august randomly assigned supine supine group erect erect group supine erect group erect supine group group patients underwent filling cystometry twice evaluated effect posture effect repetition filling cystometric parameters also evaluated correlation overactive bladder oab detrusor overactivity maximum voided volume mvv maximum cystometric capacity mcc posture filling cystometry time results decrease bladder sensation occurrence increase bladder compliance mcc supine posture group compared erect posture group significant decrease bladder sensation occurrence well increase mcc seen second filling cystometry first one supine posture first filling cystometry showed better correlation oab mvv mcc erect posture conclusions clear effects posture filling cystometry repetition urodynamic parameters supine posture repeated filling cystometry caused bladder less sensitive less overactive supine posture showed better correlation oab symptoms erect posture first filling cystometry
kinship verification interesting challenging problem human face analysis received increasing interests computer vision biometrics recent years paper presents neighborhood repulsed correlation metric learning nrcml method kinship verification via facial image analysis existing metric learning based kinship verification methods developed euclidian similarity metric powerful enough measure similarity face samples especially captured wild conditions motivated fact correlation similarity metric better handle face variations euclidian similarity metric propose nrcml method using correlation similarity measure kin relation facial images better highlighted since negative kinship samples usually less positive samples automatically identify discriminative negative samples training set learn distance metric discriminative encoded negative samples better exploited experimental results show efficacy proposed approach elsevier rights reserved
purpose identify correlates parent daughter communication abortion among nonpregnant adolescents methods nonpregnant african american females aged years attending one three charter schools chicago south side recruited surveyed regarding parental relationship quality attitudes toward sexual health communication sexual health calculated odds ratios ors ever discussing abortion using multivariable logistic regression results adolescents ever discussed abortion parent would voluntarily tell parent abortion plan feared parent would physically hurt punish evict ever communicating abortion significantly associated mother teen pregnancy confidence interval prochoice abortion attitude discussed sexually transmitted infections birth control parent perceived parental approval adolescent sexual activity ever communicating abortion inversely related sexually experienced anticipating supportive parental reactions abortion decision conclusions although almost half sample sexually active majority never talked parents abortion reported fears harm situation arise public policy focus promoting parent daughter communication unwanted pregnancy rather forcing communication occurs society adolescent health medicine rights reserved
mechanisms jak activated prevalent pseudokinase mutation blood cancers remain elusive via structure guided mutagenesis transcriptional functional assays identify community residues helix alpha linker kinase domain mediate induced activation circuit broken altering charge residues along solvent exposed face predicted interact linker mutations remove negative charges add positive charges alter fold shown crystal structure instead prevent kinase domain activation via modulation terminal residues linker results suggest strategies selective jak inhibition preservation wild type function
people defend institution marriage related beliefs committed romantic relationships sometimes stereotype discriminate single people article review research provides answers center role set commonly held beliefs romantic relationshipscommitted relationship ideology particular focus system individual level factors help explain people motivated defense consequential beliefs
transgender people often face prejudice discrimination school employment housing health care affect psychological well although literature prejudice toward transgender people growing limited research examined differences attitudes toward trans women trans men separately specifically current study examined role physical appearance acceptance transgender women men gendered spaces including bathrooms locker rooms residence halls sorority fraternity organizations participants viewed masculine appearing feminine appearing images transwoman transman measurements overall transacceptance gendered space acceptance assessed results indicated general trans women less accepted trans men masculineappearing transwomanwas less accepted gendered spaces compared feminine appearing trans woman images trans men also female participants generally accepting transgender people thanmale participants findings suggest compared trans men discrimination trans women likely especially trans woman physical appearance transgresses traditional gender expectations
study used data life histories non incarcerated incarcerated women examine extent women exposed multiple forms victimization including child abuse intimate partner violence sexual assault traumatic life events assessed effects polyvictimization multiple victimizations women healthrelated outcomes attempted suicide drug alcohol problems well whether prevalence rates effects victimization significantly different subsamples women results indicate incarcerated women experience significantly victimization non incarcerated women polyvictimization associated higher likelihood alcohol problems drug problems attempted suicide among non incarcerated women marginally associated increased likelihood alcohol problems among incarcerated women finally low levels polyvictimization affected alcohol drug problems among incarcerated non incarcerated women differently
important identify effective emotion regulation strategies increase positive emotion experience general population clinical conditions characterized anhedonia indications engaging experiential processing direct awareness sensory bodily experience bolsters positive emotion experience extensively tested memory recall test notion community participants recalled two positive autobiographical memories prior second recall participants either underwent experiential analytical distraction induction per condition subjective happiness sadness ratings heart rate variability hrv response measured recall greater spontaneous use experiential processing first memory associated greater happiness experience unrelated hrv sadness experience inducing experiential processing increased happiness experience relative analytical distraction conditions impact sadness experience significant difference hrv conditions experiential condition led trend significant increase conditions non significant decrease hrv first second memory results suggest engaging experiential processing effective way regulate positive emotion experience positive memory recall authors published elsevier ltd
high speed electric machines gaining attention several different applications development advanced materials electronic components control algorithms pushing ahead technological speed limits electromagnetic sizing machines mechanical thermal involvements tight make necessary deal different aspects time paper aims summarize discuss electrical mechanical aspects involved machine design highlighting main issues tradeoffs designer consider furthermore correlation volume reduction speed increase based commercial high frequency rotor stator units also presented
objective work prepare update imaging methods bone evaluation childhood adolescence text based original review articles imaging methods clinical evaluation bone mass children adolescents years old selected bireme pubmed means following keywords bone density osteoporosis diagnosis densitometry tomography ultrasonography magnetic resonance imaging radiogrammetry published portuguese english last years article organized topics description peculiarities advantages disadvantages imaging method possible clinical applicability despite emergence new technologies dual energy ray absorptiometry dxa remains gold standard method low bone mass diagnosis age groups however interpretation complex children adolescents demands skilled people quantitative computed tomography qct central qct peripheral qct pqct high resolution pqct pqct magnetic resonance imaging mri evaluate real bone density yet available routine use quantitative bone ultrasound qus shows good perspectives use primary prevention actions automated radiogrammetry shows promise method able flag individuals might benefit complete bone assessment clinical value measures still needs established
recent research hutter crisp humphreys waters moffit siebler confirmed combining novel social categories involves two stages hampton hastie schroeder weber furthermore also evident following stage constituent additivity second stage models involves cognitively effortful complex reasoning however current theory research addressed category conjunctions initially represented degree clear precisely first combine bind existing social constituent categories example compose temporarily store coherent representation individual shares membership female blacksmith categories article consider revised multi component model working memory baddeley assist resolving representational limitations extant two stage theoretical models new approach understanding novel conjunctions form new bound composite representations
purposeto determine mid term durability advance sling post prostatectomy incontinence ppi impact prior radiotherapy storage dysfunction methodeighty men undergoing advance sling ppi reviewed pre urodynamics pre post pad usage prior radiotherapy pgi scores recorded resultmean follow months range twelve men radiotherapy pre detrusor overactivity reduced compliance pre mean pad weight mean pads per day ppd early post period months mean ppd mid term follow mean ppd radiotherapy independently predictive poor mid term outcome men radiotherapy using ppd respectively men without factors mid term follow men without radiotherapy using less ppd compared pre operatively radiotherapy men using less ppd respectively pgi score men without radiotherapy much better radiotherapy pgi score difference conclusionthe advance sling provides mid term improvement men ppi however men radiotherapy significantly poorer outcomes mid term results indicating return baseline degree incontinence caution taken considering advance sling men pre urodynamics men radiotherapy overactive bladder may important considering men advance sling neurourol urodynam wiley periodicals inc
smart people detection systems nowadays using heterogeneous cameras paper proposes architecture focused robustly detecting people infrared visible video fusion smart environment architecture covers levels provided int horus framework initially designed perform monitoring activity interpretation tasks indeed int horus used development environment approach starts image segmentation infrared visible spectra results fused enhance overall detection performance paper describes detail int horus levels selected implement new architecture acquisition segmentation fusion identification tracking levels
one important goal developing country establish provide electric power citizens endeavor initiated government bangladesh many years ago renewable energy key component development bangladesh already made significant strides reaching country population urban rural areas renewable energy projects initiated government helping private sector non governtnent organizations ngos micro finance institutions expand solar energy program terms sustainability commercial viability projects increasing awareness among consumers suppliers benefits correct use solar home systems study therefore investigates whether solar business industry implement common strategy position country authors outline benefits using solar energy possibilities regarding solar energy system bangladesh well problems relating sector data collected via questionnaire systematic random basis results indicate significant business potentials solar energy sector perception towards renewable energy product measured terms convenience country made perception whole enhance comfort society extent also contribute economy proper sales service given consumers authors recommend initiation motivational awareness policy developers bangladesh achievement sustainable growth production renewable energy
background coronary computed tomography angiography cta allows evaluation coronary plaque volume low attenuation lipid rich component plaque vulnerability assessment purpose determine effect iterative reconstruction coronary plaque volume composition material methods consecutive patients without coronary artery disease prospectively enrolled slice images reconstructed filtered back projection fbp hybrid algorithm idose philips levels coronary plaques assessed according predefined hounsfield unit attenuation intervals total plaque interval volumes results fifty three patients mean age years included noise significantly decreased signal noise ratio snr contrast noise cnr significantly improved levels comparison fbp plaque characterization performed patients total plaques total plaque volume ranged low attenuation plaque component statistically significant differences levels fbp respectively conclusion improved image quality total low attenuation plaque volumes similar using either fbp
investigation paper coupled generalized nonlinear schrodinger cgnls equations cubic quintic nonlinearity describe effects quintic nonlinearity ultrashort optical pulse propagation fields optical fiber lax pair darboux transformation equations obtained via modified first second order vector rogue waves analytically presented variation coefficient rho relevant quintic nonlinearity time retarded induced raman process nonlinear dispersion rogue wave rotation happens rho effect wave peaks cores two different patterns second order vector rogue waves cgnls equations analyzed graphically one pattern one peak surrounded four tails pattern including three separated equal peaks finally condition modulation instability given elsevier gmbh rights reserved
quantum secure direct communication transmit secret message directly quantum channels without first generating shared secret key existing protocols quantum secure direct communication possible communicating participants quantum capabilities happens either party two participants classical capabilities paper propose semiquantum secure direct communication protocol einstein podolsky rosen photon pairs classical sender bob transmits secret message quantum alice directly checking security quantum channels bob encodes secret message alice code sequence quantum alice extracts bob secret message measuring home qubits received code qubits respectively addition demonstrate security proposed protocol individual eavesdropping attacks efficiency analysis shows protocol provide higher efficiency
currently new energy power generation booming wind energy clean renewable energy relatively low investment cost compared new energy sources therefore wind power generation broad market prospect development potential considering construction management budget conventional power plants difficulties estimation facing traditional project cost include high intensity quota query poor intelligent computing capacity low accuracy estimation conducted often combination use quota bill quantities defects one hand dynamics project cost taken account current market prices materials inflation hand fuzzy membership features contrast newly built typical project sample determined bears large subjectivity pace greatly reduced therefore necessary study proper estimation method project cost power plants compared methods neural network enjoys higher adaptability better fault tolerance fastercalculation speed andbetter solving complex nonlinear modeling problems etc efficient effective dealing multifactorial nonlinear problems papergives detailed introduction forwind power generation estimation perspectives cost estimation method traditional projects quantitative description engineering sample mode estimation models based neural network system etc
semiconductor industry demands pumps handle aggressive fluids high temperatures important step towards higher process speeds increased yield semiconductor etching applications paper presents thermal electrical mechanical design bearingless pump operating temperatures degrees without active cooling detailed thermal analysis machine presented allows prediction thermal stress critical components machine design based prediction internal temperatures hydraulic specifications pump furthermore hallsensorless observer based control rotor angle presented necessity control scheme arises high temperatures prevent usage conventional angle measurement systems
reinforcements change mechanical characteristics liquefaction resistance soils main purpose study realise behaviour static liquefaction saturated silty sand reinforced different arrangements geotextile layers several series undrained triaxial tests conducted reinforced unreinforced saturated sand sand mixed varying amounts silt factors silt content arrangement number geotextile layers discussed paper results indicate increasing silt content static liquefaction resistance decreases reinforced unreinforced silty sand increases silt content liquefaction resistance increases also found geotextile inclusion increases liquefaction resistance saturated sand silt contents examined results study limited use sand silty sand reinforced one type nonwoven geotextile
background safety warnings health authorities currently intended limit use antipsychotics aps dementia related conditions treat neuropsychiatric symptoms disturbing delusional behaviors aim study investigate prevalence correlates trends prescribing among people dementia french population methods prescribing associated factors among individuals mixed dementia vascular dementia french national alzheimer database analyzed using multivariate generalized estimating equations models results people dementia prescribed compared increase use multivariate analysis showed linear increase risk prescription adjusted odds ratio confidence interval compared factors associated prescribing male gender severe cognitive decline living long term care facilities older age higher education protective toward prescribing type dementia influence prescribing conclusion increase prescribing among individuals dementia french specialized settings last years occurred despite safety warnings phenomenon suggests alternative solutions management behavioral psychiatric symptoms populations still urgently needed
paper presents proposal implementation run function blocks icaru multiplatform environment capable running function blocks defined iec architectures computational resources virtual machine designed implemented perform networks function blocks bit platforms minimal resources also reported run bit computer two case studies performed order verify compliance iec case studies verified possible meet requirements standard configurability interoperability portability case studies also demonstrated ability environment reconfigure software runtime
extent core periphery hierarchical trade patterns significantly changed emergence asia remains debated paper addresses debate examining spatial patterns mobility asian countries global solar energy trade based network analysis shows japan singapore malaysia emerged core countries early asian core expanded six countries including japan south korea china singapore china particular moved steeply upward spatial hierarchy united states also experienced considerable vertical mobility germany stable core rise east southeast asia however decrease economic inequality internationally rather new patterns network inequality may observed within asia globally less developed southeast south asiacambodia laos myanmar pakistanexperienced marginal mobility
muscle regulatory factors mrfs play major role muscle growth development thus considered candidate genes meat production traits pigs basic helix loop helix bhlh paired box transcription factors together bone morphogenetic proteins regulate myogenesis initiate formation muscle fibers regulate transcription muscle specific genes objective study investigate mrna abundance transcription factor genes myod myf myog pax pax bmp bmp adult skeletal muscle longissimus dorsi divergent duroc high meat fat ratio pietrain low meat fat ratio pig breeds purpose purebred duroc pietrain animals breed used mrna expression study highest gene expression observed myog followed bmp lowest gene expression observed pax moreover statistically investigated differences expression profiles genes duroc pietrain breeds among seven genes myf pax showed different expression duroc pietrain breeds duroc showed higher myf pax mrna abundance compared pietrain breed although pax gene lowest expressed results suggest duroc breed may skeletal muscle regeneration potential compared pietrain breed
aluminum foam characterized architecture solid phase microstructure aim link foam morphological microstructural features mechanical properties thanks ray tomography finite element approach combining ray tomography different resolutions image processing modeling developed take account influence intermetallics foam fracture first samples scanned local tomography specimen placed close ray source images allowed observing intermetallics situ tensile test performed tomograph follow sample deformation low resolution images obtained local tomography processed create one low resolution image initial sample including details high resolution done series thresholding scaling high resolution images image used generate mesh input file obtained thanks java programs associating elements phases local scale calculated stress distribution images struts analysed work confirms presence inclusions explain fracture struts elsevier ltd rights reserved
questions remain regarding potential negative effects dietary high protein kidney health particularly context obesity risk renal disease already increased examine whether variability effects kidney health may due source protein obese zucker rats given energy protein diets containing either casein soy protein mixed source animal plant proteins weeks control lean obese rats given diets containing casein normal protein energy protein levels body weight blood pressure measured markers renal structural changes damage function assessed obesity alone resulted mild renal changes evidenced higher kidney weights proteinuria glomerular volumes obese rats increasing protein level using single mixed protein sources resulted higher renal fibrosis compared lean rats mixed protein group also lower levels serum monocyte chemoattractant protein even though diet increased kidney glomerular size soy mixed protein diets also resulted small number damaged glomeruli soy compared mixed protein diet delayed increase blood pressure time since obesity confers added risk renal disease diet mixed protein sources enables weight loss fewer risks renal health may advantageous
axial flux electrical machines afem shaped disk structure increases power weight ratio using hts materials introduction permanent magnets rotor disk superconducting coils stator disk instead conventional field armature winding respectively allows development lighter compact performing afem paper report electromagnetic properties hts coil double pancake configuration measured temperature also simulation studies means finite element constant lumped models reported commercial grade rebacuo rare earths rebco tape epoxy resin used coil winding combination experimental simulation results allow losses hts coils used superconducting machine design estimated
smart grid introduces new communication demands well multitude new hardware software asset types increase demand reliable secure asset management software paper explores database design implementation smart grid asset management application relational databases provide excellent platform upon build software focus paper object oriented database management system oodbms provides excellent model real life challenges asset management furthermore object oriented database readily converted software class models one database table makes easier develop software target database design
electric vehicles replaced many gasoline vehicles urban environments magnitude vibrations emissions electric vehicles less conventional gasoline powered vehicles however electric vehicles still mechanical vibrations created power system vehicle acceleration driveline vibration prominent work focuses vehicle vibration caused electric powertrain electric vehicles rapid acceleration deceleration gear shifting since dynamic response electric motor rapid driving torsional vibration arising acceleration deceleration gear shifting typically transmitted driveline vehicle body adversely affecting driver comfort work presents novel effective control logic reduces vibrations electric driveline system system controls electric motor suppress driveline torsional vibration transmitted driver seat effectively reducing vertical vibrations enhancing driver comfort work conducts simulations hardware tests development driveline motor control logic adaptive modeling environment simulation analytical software applied create driveline system model model structural vibrations hypermesh used dyna applied simulate free vibration forced vibration analytical results free vibration compared empirical data analytical results driveline dynamics applied input finite element model analyze forced vibration vibrations electric driveline move motor mount frame driver seat track simulation results demonstrate control logic strategy applied electric bus motor controller effectively reduces fluctuation driveline torque acceleration gear shifting reduction vibration driver seat track fixed gear acceleration maximal reduction gear shifting
validate thai language version psoriasis epidemiology screening tool pest early arthritis psoriatic patients questionnaire earp well also develop new tool screening psoriatic arthritis psa among psoriasis patients cross sectional study patients visiting psoriasis clinic siriraj hospital recruited completed earp pest full musculoskeletal history examination radiography evaluated psa diagnosed rheumatologist evaluation fulfillment classification criteria psoriatic arthritis receiver operator characteristic roc curves sensitivity specificity used evaluate performances tools siriraj psoriatic arthritis screening tool sipat contained questions relevant peripheral arthritis axial inflammation enthesitis selected multivariate analysis total patients prevalence psa roc curve analyses thai earp pest sipat respectively sensitivities sipat thai earp pest respectively specificities respectively screening questionnaires showed good diagnostic performances sipat could considered screening tool desirable properties higher sensitivity taking less time thai pest earp could possibly sequentially administered people positive test sipat reduce number false positives
conoscopy visualisation birefringence materials using depolarisation light passing broad range incident orientations recent years conoscopy become important optical tool science soft materials liquid crystals polymers widely applied materials engineering development example technologies ranging display optics plastic food packaging paper reports fisheye lens conoscopy fundamentally new broadly applicable optical approach conoscopy particularly appropriate study soft materials capabilities illustrated using fisheye lens system characterise birefringent polarising polymer films liquid crystal test cells addition birefringence measurement fisheye conoscopic determination emission characteristics commercial light emitting devices liquid crystal displays transmission topographically patterned light control films presented demonstrating fisheye methodology broadly applied determine angular dependence light emission transmission advanced optical technologies applications
visual system development depends neural activity driven intrinsic light sensitive mechanisms examined effects retinal function due exposure summer winter like circadian light cycles development adulthood retinal light responses visual behaviors dopamine content retinal morphology gene expression assessed mice reared seasonal photoperiods consisting light dark cycles respectively mice exposed short winter like light cycles showed enduring deficits photopic retinal light responses visual contrast sensitivity transient changes observed scotopic measures dopamine levels significantly lower short photoperiod mice dopaminergic agonist treatment rescued photopic light response deficits tyrosine hydroxylase early growth response factor mrna expression reduced short photoperiod retinas therefore seasonal light cycles experienced retinal development maturation lasting influence retinal visual function likely developmental programming retinal dopamine
social interactions play important role overall well current practice monitoring social interactions questionnaires surveys inadequate due recall bias memory dependence high end user effort however sensing capabilities smart phones play significant role automatic detection social interactions paper describe method detecting interactions people specifically focusing interactions occur synchrony walking walking together subjects important aspect social activity thus used provide better insight social interaction patterns work rely sampling smartphone accelerometer sensors analyse accelerometer data separately combine detect walking synchrony results show seven days monitoring using seven subjects real life setting achieve accuracy precision recall detection rates combining modalities
comment witch hunt narrative twhn cheit first hypothesis twhn argues famous ritual child abuse cases really witch hunts response criticize twhn definition witch hunt overly narrow idiosyncratic based scholarly literature propose criteria identifying witch hunt rate four well known ritual child abuse cases criteria show classic witch hunts second hypothesis twhn argues defendants child ritual abuse cases guilty probably guilty response point many instances twhn omitted mischaracterized important facts ignored relevant scientific information running contrary hypotheses conclude twhn often factually inaccurate tends make strong assertions without integrating relevant scholarly scientific information scholars approach book caution
background speech language impairments well established individuals amyotrophic lateral sclerosis als however knowledge particular aspects social communication everyday conversational abilities limited aims investigate self informant report ratings social communicative abilities als participants matched healthy controls methods procedures thirty two participants als controls completed trobe communication questionnaire lcq participants nominated close provide informant report lcq demographic clinical information also collected outcomes results informant ratings indicated greater difficulties conversational initiation effectiveness partner sensitivity als participants compared controls als participants rate social communicative abilities poorer controls self reports differed informant ratings control group lcq scores significantly correlated clinical functional variables conclusions implications social communication reduced als individuals may lack insight difficulties order understand provide targeted interventions difficulties clinical speech language assessment incorporate social communication assessment including self informant report format
growing computational power modern cpus allows increasingly complex signal processing applications successfully implemented executed general purpose processors operating systems regard application architecture design operating system integration directly affect maximal achievable processing bandwidth paper present alternative driver architectures signal processing applications differ distribution processing stages kernel space user space using processing ads air traffic radio signals civil aviation case study evaluate performance design alternatives linux system quantify strengths weaknesses respect data overhead usage vector units applicable compiler optimizations cache behavior based results determine best design choice derive guidelines development efficient signal processing applications
propose many giver recipient discrepancies gift giving literature explained least partially notion evaluating quality gift givers primarily focus moment exchange whereas recipients primarily focus valuable gift owned review summarize variety errors givers make critically position errors within newly developed framework hope framework provide single point reference interested gift giving spur novel predictions causes consequences miscalibrated gift choice
memory thought constructive process cortical regions associated processing event features reactivated retrieval although evidence non detailed cortical reactivation retrieval memory visual auditory information reactivates visual auditory processing regions respectively limited evidence memory reactivate cortical regions associated processing detailed feature specific information evidence critical understanding mechanisms episodic retrieval present functional magnetic resonance imaging fmri study assessed whether lateral occipital complex loc region preferentially processes shape associated retrieval shape information encoding participants presented colored abstract shapes either intact scrambled retrieval colored disks presented participants indicated whether corresponding shape previously intact scrambled assess whether conscious retrieval intact shapes reactivated loc conducted conjunction shape perception encoding accurate versus inaccurate retrieval intact shapes produced many activations loc determine whether activity loc specific intact shapes conducted conjunction shape perception encoding intact versus scrambled shapes also produced many activations loc furthermore memory intact shapes hemifield produced contralateral activity loc memory left visual field intact shapes activated right loc reflects specific reinstatement perception encoding activity present results extend previous feature specific memory reactivation evidence support view memory constructive process elsevier rights reserved
posttraumatic stress disorder ptsd one psychological conditions predict suicidal behavior among think suicide many patients ptsd present clinically elevated suicide risk expert consensus practice guidelines recommend trauma focused treatments patients elevated suicide risk however research aimed understanding common mechanisms underlie association ptsd suicide risk led several advances effective care suicidal patients diagnosed ptsd based results various combinations sequences suicide focused treatments risk management procedures trauma focused treatments implicated
investigate roles plasma vascular endothelial growth factor vegf level vegf gene polymorphisms ankylosing spondylitis susceptibility plasma vegf level measured using enzyme linked immunosorbent assay vegf gene polymorphism analyzed matrix assisted laser desorption ionization time flight mass spectrometry data indicated average plasma vegf concentration patients markedly higher controls stratification analysis indicated significant correlation elevated plasma vegf level patients sex age hla reactive protein crp grade sacroiliac joint also found vegf associated decreased risk significant differences found vegf genotypes elevated plasma level patients compared controls however find significant association plasma vegf level different genotypes patients controls sum serum vegf levels significantly associated inflammatory process study suggests vegf involved immunological inflammatory process european federation immunological societies published elsevier rights reserved
wide array social decisions relies social comparisons decisions require fast access relative information therefore expect signatures comparative process observable electrophysiological components early stage information processing however date little known neural time course social target comparisons therefore tested hypothesis electroencephalography eeg studies using social distance effect paradigm distance effect capitalizes fact stimuli close certain dimension take longer compare stimuli clearly differing dimension manipulated distance face characteristics regarding levels attractiveness study trustworthiness study essential social dimensions studies size comparisons served nonsocial control condition study distance related effects apparent vertex positive potential vpp stimulus onset attractiveness comparisons study trustworthiness comparisons took effect already likewise carried event related remarkably observed similar temporal pattern social attractiveness trustworthiness nonsocial size dimensions results speak favor early encoding comparative information emphasize primary role comparison social information processing
serum derived bovine immunoglobulin protein isolate sbi oral nutritional therapy efficacious diverse diarrheal diseases open label study patients irritable bowel syndrome diarrhea ibs evaluated effects sbi twice day weeks safety bowel function abdominal pain tryptophan metabolism ratio intestinal permeability mannitol lactulose excretion bile acid synthesis fasting serum fgf duodenal stool microbiome expression genes related inflammation immune function tight junctions duodenal mucosa statistical analysis paired tests baseline treatment based intention treat itt principles one caucasian patients age bmi withdrew without completing studies improvements stools day decrease ease passage evacuation sbi therapy worst pain severity numerically reduced last weeks treatment duodenal mucosal mrna expression serum fgf ratio small bowel colon permeability stool microbiome significantly different sbi therapy compared baseline duodenal brushings considerable microbiota structure difference diversity analysis unifrac taxonomic analysis increased abundance proteobacteria burkholderiales firmicutes catonella unclassified genus organisms sbi therapy thus sbi therapy weeks ibs patients associated improved bowel function mechanism benefit unclear though microbiota structure differences duodenal brushings studies patients low grade inflammation intestinal barrier dysfunction baseline indicated
vinyl methyl oligosiloxane resin synthesized hydrolytic sol gel reaction vinyltriethoxysilane dimethyldiethoxysilane hydrochloric acid added catalyst promote hydrolysis silane monomers form highly condensed siloxane resin condensation degree vinyl methyl oligosiloxane hydrogen methyl oligosiloxane resin cured thermal hydrosilylation reaction minimal platinum catalyst content ppm increased cross linking density improved thermal decomposition temperature lowered weight loss high temperature fabricated methyl siloxane hybrid material hybrimer shows superior thermal stability decomposition temperature degrees good long term thermal resistance degrees transparency visible ultraviolet ranges based characteristics methyl siloxane hybrimer applied various applications including thermally stable optical materials graphics
kidneys exhibit age associated deterioration function via loss kidney mass particularly renal cortex increased fibrosis oxidative stress found mediate age associated renal cell injury cell death particularly apoptosis oxidative stress results imbalance levels free radicals generated aerobic metabolism inflammation infection safe breakdown species endogenous exogenous scavengers factors may influence pathologies example growth hormone caloric restriction shown influence life span although neither method prolonging life likely find general acceptance humans genetic knockout models offer promise example knockout isoform shc gene mice increases life span appetite size fertility retained whether increase life span via increased kidney health yet clear decreasing age related renal pathologies doubt aid increasing life span health general review looks role modulation factors influence life span particular modulation oxidative stress particular relevance age related renal pathologies national kidney foundation inc
objective disparities tobacco use persist despite successful policies reducing use within united states particular prevalence tobacco use rural certain minority communities significantly higher compared counterparts work examine impact rurality mental health racial discrimination tobacco use methods data come california health interview survey modified poisson regression models adjusted age sex race ethnicity birth origin education income insurance marital status results compared urban residents rural residents significantly higher risk smoking adjustment reported experienced racial discrimination also significantly greater risk smoking compared additionally reported higher stress significantly greater risk smoking evidence interaction rurality race ethnicity rurality gender conclusion residing rural areas associated increased risk smoking beyond sociodemographics significant differences across rural urban environments relationship stress tobacco use indication impact stress discrimination buffered exacerbated environmental characteristics potentially found either location mechanisms explain rural urban tobacco use disparities need explored smoking cessation programs policies tailored target factors within rural communities
amyloid beta precursor protein app normally cleaved alpha secretase also cleaved secretase bace produce fragments endoplasmic reticulum membrane subsequently cleaved amyloid beta beta aggregation known cause alzheimer disease therefore removing preventing disease selenoprotein sels membrane protein participating endoplasmic reticulum associated degradation erad one stages resolving stress misfolded proteins accumulated erad postulated one processes degrade however remains unclear degradation depends sels study investigated effect sels degradation observed sels colocalized membrane fraction mouse neuroblastoma neuroa cells level sels increased stress level decreased however despite induction stress change amount sels knock cells interaction vcp essential component erad complex occur sels knock cells ubiquitination decreased sels knock cells also found extracellular amount beta relatively higher sels knock cells control cells results suggest sels required degradation erad resulting inhibition beta production elsevier inc rights reserved
flow ree eyring casson non newtonian fluids investigated using variational principle optimize total stress variationally obtained solutions compared analytical solutions derived weissenberg rabinowitsch mooney equation results found identical within acceptable numerical errors modeling approximations
study examined parent offspring communication disgust related information effects children feelings disgust fear towards animal mothers instructed provide information novel animal children studying secrecy either disgusting neutral attributes allegedly characteristic animal first mothers instructed nonverbal way also allowed use verbal utterances results indicated nonverbal communication disgust mothers failed produce effects offspring subjective evaluations animal however verbal information transmission differential impact children feelings disgust fear children mothers verbally communicated set disgusting specimens displayed higher levels disgust cohen also exhibited higher levels fear cohen towards novel animal compared children mothers verbally communicated neutral specimens effect fear mainly due fact children verbal neutral information exhibited clear decline fear whereas children mothers provided verbal disgust information maintained similar level fear towards animal implications results familial transmission disgust fear discussed
objective sexual assaults women global health crisis alarmingly high rates south africa however know little circumstances aftermath experiences limited information factors specific rape fighting back versus specific individual potentially modifiable influence mental health outcomes study examined situational characteristics rape well individual situational factors confer risk symptoms depression posttraumatic stress disorder ptsd dysfunctional sexual behavior month follow method two hundred nine south african women recruited rural rape clinics limpopo province north west province nwp south africa interviews conducted baseline within months rape incident months trained staff clinics english women native languages women interviewed services provided private room results one hundred thirty two women lost follow months resulting women interview data time points undermining survivor social support system increased belief myths rape associated increased dysfunctional sexual practices symptoms depression conclusions findings demonstrate need interventions address pervasive effects rape time behaviors increase risks revictimization reduce psychological well aftermath rape
overview given work laboratory nuclear energy systems eth zurich ethz laboratory thermal hydraulics paul scherrer institute psi switzerland tight lattice bundles two phase flow subchannels tight triangular lattice studied experimentally computational fluid dynamics simulations two adiabatic facilities used vertical channel modeling pair neighboring sub channels arrangement four subchannels one subchannel center first geometry equipped two electrical film sensors placed opposing rod surfaces forming subchannel gap recorded liquid film thickness distributions domain measuring points time resolution khz bubbly slug flow regime information bubble size shape velocity residual liquid film thickness underneath bubbles obtained second channel investigated using cold neutron tomography allowed measurement average liquid film profiles showing effect spacer grids vanes results reproduced large eddy simulation volume fluid outlook novel nonadiabatic subchannel experiment introduced driven steady state dryout refrigerant heated heavy water circuit allows application cold neutron tomography copyright published elsevier korea llc behalf korean nuclear society
goal study find moderating role type industry different levels management respect elearning perception elearning advantages use elearning stress management study tried find relationship perceptions elearning elearning advantages perception using elearning corporate training specifically stress management cross sectional survey conducted structured questionnaire collect data managers working different levels including manufacturing sector services sector results study show positive relationship perception elearning elearning stress management relationship significantly stronger services industry positive relationship elearning advantages elearning stress management relationship significantly stronger manufacturing industry study also revealed positive relationship elearning perception elearning stress management relationship significantly stronger senior management middle management
aim assess plasma levels cortisol cytokines cocaine dependent women without childhood maltreatment history cocaine detoxification treatment method assessed immunoendocrine clinical parameters crack cocaine female users weeks inpatient detoxification treatment healthy women obtain reference values women without history identified answering childhood trauma questionnaire ctq blood samples clinical assessment collected lunch first second third week post treatment admission flow cytometry used assess tnf alpha ifn gamma plasma levels elisa assay used measure plasma cortisol levels results baseline lower thl related cytokines levels higher cytokines levels observed crack cocaine users compared reference values cytokines levels cocaine dependents gradually became closer reference values along detoxification treatment however groups compared increased levels tnf alpha across time observed group additionally immune imbalance observed within group negatively correlated severity crack withdrawal finally loading trauma exposure severity immunoendocrine clinical parameters factor analysis identified three clusters observed variables detoxification systemic immunity trauma exposure pro inflammatory immunity behavior conclusion results suggest existence immunological phenotype variant associated exposure crack cocaine detoxification women elsevier ireland ltd rights reserved
grey water constitutes largest fraction domestic wastewater causes environmental sanitation pollution problems managed well treated grey water resource variety uses pilot system constructed february treat grey water four member household sub surface irrigation local vegetables hydraulic loading rate hlr organic loading rate olr bod implemented multi media filter gravel charcoal geotextile mulch charcoal predominant layer operated batched type system hour retention time system operated months showed remarkable removal efficiencies hours chemical oxygen demand cod biochemical oxygen demand bod respectively faecal coliforms removal efficiencies hours total nitrogen total phosphorus tot total suspended solids tss total dissolved solids tds respectively plant response sub surface irrigation treated grey water largely masked rainy season effluent limited effect soil
mental health needs common among community corrections offenders many enrolled form supervised mandated treatment one category mental health problem may germane treatment completion recidivism among legally supervised treatment diagnosis personality disorder systematic review reports sixteen studies comprised full mixed legally supervised samples offender community based treatment examines impact pds treatment completion studies difficult compare differences program setting definition treatment completion definition method assessment type treatment among variables impact antisocial personality disorder treatment common focus pds rarely assessed relevance dsm categories offender management community corrections well limitations current diagnostic categories discussed
electrochemical impedance spectroscopy eis label free method molecular detection particular interest biomedical applications aim create hand held easy use eis measurement device biomolecular detection electrochemical cyclic voltammetry systems help millions diabetics monitor blood glucose levels times per day use limited due poor lower limit detection eis technique used detect much larger array biomolecules low concentration eis system generates magnitude phase impedance test samples via matlab provides real imaginary components impedance circuit integrated single chip fabricated standard cmos technology hand held eis measurement system built using chip arduino uno measure randles circuit equivalent frequency range khz measurement simulation results show excellent agreement
ability read mental states subtle facial cues important part theory mind contribute children daily life social functioning mental state reading performance influenced specific interactions applied familiarity characteristics interactions person enhance performance aim research gain insight context effect mental state reading children assessed reading mind eyes rme task originally consists pictures adults eyes differences children adults roles development frequency interaction children familiar mental state reading children therefore expected children mental state reading depends whether assessed children adults eyes new item version rme children constructed pictures children instead adults study task used compared original child rme year olds study year olds study children groups performed better new rme original rme item level findings new rme line previous findings task test test reliability subgroup older children adequate suggests rme children eyes assess children daily life mental state reading supplement existing tom tasks
individuals bipolar disorder high rates nonadherence medical illness premature mortality analysis reexamined correlates poor adherence nonpsychiatric medication patients medical comorbidities majority female african american mean age years mean duration years mean years education mean proportion days missed doses past week sex age education race living alone correlate adherence medications severe psychiatric symptoms correlated worse adherence specifically poor adherence correlated retardation vegetative factors montgomery angstrom sberg depression rating scale affect factor brief psychiatric rating scale among poorly adherent patients medical comorbidities number medications tension anxiety somatic symptoms depression related worse nonpsychiatric medication adherence
cachexia frequent manifestation pancreatic cancer limit patient ability take chemotherapy associated shortened survival developed model predict early onset cachexia advanced pancreatic cancer patients patients newly diagnosed untreated metastatic locally advanced pancreatic cancer included serum cytokines drawn prior therapy patient symptoms recorded using anderson symptom inventory mdasi primary endpoint either weight loss death within days start therapy twenty seven patients met primary endpoint either lost body weight died within days start treatment univariate analysis smoking history symptoms pain difficulty swallowing high levels cxcl tnf low correlated endpoint used recursive partition fit regression tree model selecting four variables cxcl pain swallowing difficulty important predicting cachexia model two cytokines cxcl demonstrated better sensitivity specificity outcome respectively individual cytokine tumor marker cachexia frequent pancreatic cancer one three patients met endpoint weight loss death within days inflammatory cytokines better conventional tumor markers predicting outcome recursive partitioning analysis suggests model cxcl may offer better ability individual cytokines predict outcome
loosely coupled applications composed potentially large number tens thousands even billions tasks commonly used high throughput computing many task computing paradigms efficiently execute large scale computations exceed capability single type computing resources within expected time able effectively integrate resources heterogeneous distributed computing hdc systems clusters grids clouds paper quantitatively analyze performance three different real scientific applications consisting many tasks top hdc systems based partnership distributed computing clusters grids clouds understand application resource characteristics show practical issues normal scientific users face course leveraging systems experimental study shows performance loosely coupled application significantly affected characteristics hdc system along hardware specification node impacts performance vary widely depending resource usage pattern application devise preference based scheduling algorithm reflect characteristics resource usage patterns various loosely coupled applications running top hdc systems experimental study preference based scheduling algorithm allocate resources different hdc systems loosely coupled applications based preferences applications hdc systems evaluate overall system performance various preference types using trace based simulations determined based different factors cpu specifications application throughputs simulation results demonstrate importance understanding application resource characteristics effective scheduling loosely coupled applications hdc systems
new photochromic diarylethene bearing naphthyl unit synthesized efficiently photochromic properties fluorescence property examined hexane solution pmma film concentration effect hexane solution investigated also results indicated photochromic diarylethene good photochromic property exhibit remarkable fluorescence switching property concentration mol fluorescence peak maximum
almost cancers attributable preventable cancer risk factors related behavior health professionals must take account respective weight different causes cancer enforce effective cancer prevention involvement needed several levels primary prevention vaccinations detection support withdrawal addiction also greater consideration patients cancer risk behavioral factors involvement essential care monitoring patients cancer thus enhancing patient compliance cancer prevention tips stopping smoking reducing alcohol consumption practice physical activity physical inactivity reduction reduction overweight adopting diversified balanced diet appears new challenge personalized care oncology aims reduce incidence cancer also reduce risks morbidity long term mortality
nirk gene encoding copper containing nitrite reductase cunir key catalytic enzyme environmental denitrification process helps produce nitric oxide nitrite molecular mechanism denitrification process definitely complex case theoretical investigation conducted know sequence information amino acid composition active site cunir enzyme using various bioinformatics tools fasta formatted sequences retrieved ncbi database domain disordered regions identification phylogenetic analyses done sequences comparative modeling protein performed modeller program visualized pymol tools validated protein models deposited protein model database pmdb pmdb active sites nirk encoding cunir enzyme identified castp server procheck showed significant scores four protein models favored regions ramachandran plot active sites cavities prediction exhibited amino acid namely glycine alanine histidine aspartic acid glutamic acid threonine glutamine common four predicted protein models present silico study anticipates active site analyses result pave way research complex denitrification mechanism selected species experimental laboratory published elsevier ltd
china quickly installing advanced metering infrastructure ami could provide tremendous opportunities developing utilizing demand response resources demand response may potentially create profitable industry contribute efficiency improvement cost reduction pollution mitigation entire electricity sector however china lags behind developed world utilizing demand response institutional barriers including lack competitive electricity market resistance state grid corporations preventing commercialization demand response order fully realize potential smart grid china needs push forward reforms toward establishing open access electricity market pollution free demand response resources may compete power generators leveled field elsevier rights reserved
elevated concentrations plasma fatty acids transition dairy cows significantly associated increased disease susceptibility poor lactation performance main source plasma fatty acids throughout transition period lipolysis adipose tissue depots time plasma fatty acids serve source calories mitigating negative energy balance prompted copious milk synthesis limited dry matter intake past research demonstrated lipolysis adipose organ complex process includes activation lipolytic pathways response neural hormonal paracrine stimuli also important changes structure cellular distribution tissue process known adipose tissue remodeling process involves inflammatory response immune cell migration proliferation cellular components stromal vascular fraction changes extracellular matrix review summarizes current knowledge lipolysis dairy cattle expands new field adipose tissue remodeling discusses biological processes affect transition cow health productivity
fields smart materials still demand material featuring high modulus low density large strain carbon materials catch enormous scientific attention since carbon fibers used high performance composite structures scientific attention moves macroscale nanoscale paper focuses adaptive point view one carbon allotropes carbon nanotubes cnts beside excellent electromechanical properties another interesting feature first mentioned active behavior paper like mats bucky papers made cnts cnt papers electrically activated using double layer interaction ions provided electrolyte charged high specific surface area paper formed carbon nanotubes detailed mechanism behind strain force generation cnt based architectures unknown clarification principle reveals potential carbon tubes resilient smart material order use strong covalent carbon bonds instead weak van der waals force tube linking paper presents investigations composition cnt papers performance contrast vertical aligned cnt arrays using actuated tensile test set better comparison experiments specimen types carried dry wet wet charged conditions especially case cnt arrays essential preload specimens curly cnt structure superimposes vertical orientation cnt paper tested aqueous solution one molar sodium chloride hydrophobic character cnt arrays requires ionic liquid electrolyte found mechanical properties cnt papers drop significantly wetting controlled charging indicates electrostatic dominated effect contrast cnt arrays show identical results regardless test conditions furthermore active reversible behavior tube elongation charging results indicate strongly quantum mechanical effect reason cnt array actuation
brushless motor bldc widely used many industrial applications high efficiency high torque low volume paper focuses speed control bldc motor using soft computing technique problems related control systems undesirable overshoot longer settling times vibrations going one state another overcome maximum overshoot longer settling times pid self tuning fuzzy pid control techniques used closed loop controller architecture speed control bldc motor simulated using matlab simulink results obtained simulation results revealed proposed self tuning fuzzy pid controller provides better performance conventional controller prototype model bldc motor presented speed response bldc motor observed lcd display
numerically robust approach steady state calibration nonlinear dynamic models presented approach based explicit formulation constraints validity internal model signals set inequalities constrained optimization feasible iterates guarantees model never evaluated invalid internal signals overcomes numerical difficulties often encountered dealing highly nonlinear models approach uses large number slack variables distributed least squares algorithm proposed robustness approach demonstrated steady state calibration turbocharged diesel engine model starting grossly inaccurate initial estimates elsevier ltd rights reserved
healthy sleep characterized several stages deep sleep light sleep rem sleep show sleep stages lead different autonomic regulation breathing using detrended fluctuation analysis fourth order find breath breath intervals breath volumes separated several breaths long range correlated rem stages wake states contrast non rem stages deep sleep light sleep long range correlations absent behaviour similar correlation behaviour heart rate night may related phase synchronization heartbeat breathing found recently speculate differences caused different cortically influenced control autonomic nervous system elsevier science rights reserved
statelessness functional computations facilitates parallelism fault recovery faults non uniform communication topologies key challenges emergent large scale parallel architectures report hdph hdph pair haskell dsls designed address challenges irregular task parallel computations large distributed memory architectures dsls share api combining explicit task placement sophisticated work stealing hdph focuses scalability making placement stealing topology aware whereas hdph delivers reliability means fault tolerant work stealing present operational semantics dsls investigate conditions semantic equivalence hdph hdph programs conditions topology awareness transparently traded fault tolerance detail dsl implementations realise topology awareness fault tolerance report initial evaluation scalability fault tolerance core cluster cores hpc platform
considering role prosocial behaviors oxytocin suggested diminish levels aggression nevertheless recent findings indicate oxytocin may broader influence increasing salience social stimuli may therefore certain circumstances increase antisocial behaviors aggression controversy led following speculations indeed oxytocin promotes primarily prosocial behavior administration expected diminish levels aggression however oxytocin mainly acts increase salience social stimuli expected elevate levels aggression following provocation order test assumption used social orientation paradigm sop monetary game played fictitious partner allows measuring three types responses context provocation aggressive response reducing point fictitious partner individualistic response adding point oneself collaborative response adding half point partner half point oneself current double blind placebo controlled within subject study design participants completed sop task following administration oxytocin placebo results indicated among subjects naive procedure oxytocin increased aggressive responses comparison placebo results support saliency hypothesis oxytocin suggest oxytocin plays complex role modulation human behavior elsevier inc rights reserved
research focuses using analytical fluid mechanics determine whether mitral regurgitation patient echocardiogram reading trusted assess severity mitral regurgitation occurs mitral valve inlet separating left atrium left ventricle fully close ventricular systole allowing regurgitant blood flow backwards left ventricle left atrium clinicians knowing severity hack flow important preventing eventual heart failure coanda effect phenomenon particular patient believed cause discrepancies echocardiogram results leading clinicians sometimes incorrectly diagnose patient severity propose generate tool reading undebatable solid geometries echocardiogram using judge prevalence wall effect distort fluid jet read using control volume analysis regurgitant jet mitral valve analytical solution expected flow profile based wall effects around regurgitant jet derived using turbulent ansys model detailed velocity momentum mappings blood flowing backwards mitral valve left atrium obtained believe first steps towards understanding wall effects determining level trustworthiness echocardiogram reading severity
development network technology brought convenience people life also provides convenience virus trojan destructive programs attack network computer network security becoming dangerous accurately scientifically predict risk network effectively prevent risk reduce loss caused problem computer network security computer network security early warning problem multi index system traditional linear forecasting method accurately describe impact index evaluation results accuracy prediction results low order improve prediction accuracy computer network security paper presents new forecasting method computer network security firstly evaluation index computer network security selected expert system weight evaluation index determined expert scoring method secondly put index weight neural network use neural network learn parameters neural network optimized improved particle swarm optimization algorithm paper uses method based fibonacci method principle find number hidden layer node best fitting ability finally use algorithm predict network security certain enterprise next six months score close actual value network security
small urbanized areas uas defined census environmental protection agency epa population population density least people per square mile phase national pollutant discharge elimination system storm water managers uas must preserve predevelopment hydrology compliance qualitative regulations often impracticable task given limited resources municipal authorities diffuse hydrologic impacts urbanization objective paper assist storm water managers providing geographic information system gis workflow supported python scripting produces geographic database storm water infrastructure subsequently used create fully parameterized hydrologic hydraulic model guidance calibrating model provided suggestions measuring discharge storm sewer systems application objectives demonstrated watershed blacksburg virginia unique municipal academic partnership fostered development work finally improvements research ideas suggested storm water management small uas american society civil engineers
study examined objective quality life work academic success living situation relationships support system subjective quality life sense coherence short form health survey adult sample males mean age years asperger syndrome diagnosed childhood followed prospectively two decades association long term diagnostic stability autism spectrum disorder comorbid psychiatric disorders quality life also examined results showed great variability regards quality life subsample longer fulfilled autism spectrum disorder full time jobs studies independent living reported two friends stable autism spectrum disorder group full time job studies lived independently reported two friends significant minority specialized employments lived support government friends academic success positively correlated majority total group scored average sense coherence scores mean short form health survey average regarding psychical health average regarding mental health stability autism spectrum disorder diagnosis associated objective subjective quality life psychiatric comorbidity associated subjective objective quality life
rapid analytical approach assay resveratrol red wines based paper spray mass spectrometry multiple reaction monitoring mrm described assay involves use stable isotope dilution method analytical parameters calculated analyzing fortified samples confirm reliability proposed approach accuracy values lod loq values calculated respectively furthermore recovery quantitative analyte reproducibility rsd checked different days wine always highlighted consistency methodology elsevier ltd rights reserved
background increasing trend incidence mumps observed developing countries recent years presenting major threat children health studies examined relationship meteorological factors mumps inconsistent findings methods daily data meteorological variables mumps obtained jining temperate inland city china generalized additive model used quantify association meteorological factors mumps based exposure response relationship results total mumps cases included study found nonlinear relationship daily mean temperature sunshine duration relative humidity mumps approximately linear association mean temperature degrees excess risk degrees increase confidence interval current day relative humidity increase lag day sunshine duration higher per increase lag day found linear effects daily wind speed lag day conclusions study suggests meteorological factors might important predictors incidence mumps considered control prevention elsevier rights reserved
detailed discussion genesis determinant algorithmic method harmonic distortion switched capacitor integrator switched capacitor based second order sigma delta modulator presented many instances people make harmonic distortion analysis signal expanding periodic signal fourier series making fourier transformation non periodic signal respectively actually due complexity transient response switched capacitor integrator output expression second order sigma delta modulator loop filter also trivial great trouble traditional method employed harmonics analyzed calculated way fact noteworthy matter complicated output response second integrator modulator harmonic expression functional form whether whole time domain discrete time moments turn harmonic analysis continuous time transient response another thing namely computing harmonic coefficients transient response discrete time moments least square method adopted process calculation developing output expression second order sigma delta modulator following point clarified harmonic distortion dominated first switched capacitor integrator owing suppression resulted closed feedback harmonic distortion second stage much greater first stage addition avoided harmonic distortion brought feedback signal calculation way first additive harmonic error model utilized get transfer function second replaced gain model form power series feasibility simplicity analysis mathematical derivation enhanced effectively
atomic layer deposition ald enabling technology provides coating material features significant advantages compared existing techniques depositing precise nanometer thin two dimensional nanostructures cyclic process relies sequential self terminating reactions gas phase precursor molecules solid surface ald especially advantageous film quality thickness critical offering ultra high aspect ratios ald provides digital thickness control atomic level depositing film one atomic layer time well pinhole free films even large complex areas digital control extends sandwiches hetero structures nano laminates metal oxides graded index layers doping perfect conformal coating challenging electrodes various functional devices technique capabilities presented example ald developed ultra thin tungsten oxide large area standard substrates discussed advantages ald enable endorse employment technique development hetero nanostructure semiconductors unique properties elsevier rights reserved
paper presents two within subjects studies exploring different combinations visual auditory feedback influence perceived realism virtual self perception experience safety walks virtual platform suspended canyon first study frequency factor footstep sounds altered visual appearance changed newly built wooden bridge old bridge weaker structure broken planks second study sounds creaking wood added footstep sounds half trails compared footsteps without creaking sounds moreover frequency factor frequency controls footsteps also manipulated trails visual appearance bridge limited model old broken bridge
photocatalytic water splitting generation clean hydrogen energy received increasingly attention field photocatalysis study tao heterojunctions successfully fabricated via simple one step heating strategy photocatalytic activity prepared photocatalysts evaluated water splitting hydrogen evolution visible light irradiation lambda compared pristine obtained heterojunctions exhibited remarkably improved hydrogen production performance found heterojunction presented best photo catalytic hydrogen evolution efficiency times higher pure moreover sample also displayed excellent photochemical stability even photocatalytic test experimental study enhanced photo catalytic activity mainly attributed significantly improve interfacial charge separation heterojunction tao work provides facile approach design based photocatalyst develops efficient visible light driven heterojunction application solar energy conversion published elsevier ltd behalf hydrogen energy publications llc
patients anorexia nervosa strong ability limit food intake thus dysfunctional approach avoidance behaviors towards food evident applied approach avoidance task aat patients controls either approached pull avoided push high low calorie food pictures based solely presented picture format landscape portrait tested hypothesis opposition controls displaying approach bias towards food cues patients would show avoidance bias measured different response times towards food explicit ratings food cues also performed found significant interaction group direction anovas performed two groups separately showed main effect direction motion controls patients two groups differ reaction times rts regard push however rts regard pull significantly different groups controls show clear approach bias expressed significantly faster rts pull compared push independent calorie content food stimuli approach bias absent group patients indicative global loss incentive value food implicit trainings add psychotherapy patients asked elsevier ltd rights reserved
despite infant weaning one challenging aspects parenting uncertainty right time start research aimed understand impact newspaper reporting weaning parents particular focussing coverage scientific report published british medical journal using media analysis weaning articles national newspapers mumsnet internet discussion forum analysis able explore forum members reacted reporting embellished communication weaning issue adding personal advice experience case study shows role discussion forums science communication provide new arena studying audience effects
background objectives dialectical behaviour therapy dbt trains participants use behavioural skills managing emotions study aimed evaluate whether skills use associated positive treatment outcomes independently treatment processes common across different therapeutic models method use dbt skills three common treatment processes therapeutic alliance treatment credibility self efficacy assessed every months year individuals borderline personality disorder receiving dbt mixed multilevel modelling used determine association factors frequency self harm treatment dropout results participants used skills less often timepoint likely drop dbt subsequent two months independently self efficacy therapeutic alliance perceived treatment credibility frequent use dbt skills higher self efficacy independently associated less frequent concurrent self harm treatment credibility alliance independently associated self harm treatment dropout limitations skills use measure could applied control group receive dbt sample size insufficient structural equation modelling conclusion practising dbt skills building increased sense self efficacy may important partially independent treatment processes dialectical behaviour therapy however direction association variables self harm requires evaluation elsevier ltd rights reserved
multiple sclerosis immune mediated disease affecting central nervous system cns magnetic resonance imaging mri long recognized important tool diagnosis increasingly recognized addition role diagnosis mri play key role noninvasive tool prognostication disease monitoring assessment treatment efficacy safety monitoring disease modifying therapies dmts confluence factors including increased availability mri development improved mri techniques increased availability dmts contributed expanding role mri clinical care clinical use mri expands important mri protocols amongst clinical centers standardized summarize recent evidence supporting use mri clinical practice summarize various clinical guidelines recommendations use mri disease monitoring provide recommendations standardized mri protocols
non invasive techniques quantifying early biochemical biomechanical changes articular cartilage may provide means precisely assessing osteoarthritis progression goals study determine relationship rho magnetic resonance imaging relaxation times changes cartilage composition cartilage mechanical properties synovial fluid biomarker levels demonstrate application trho imaging evaluate cartilage composition human subjects vivo femoral condyles synovial fluid harvested healthy porcine knee joints sagittal trho relaxation images condyles acquired regions joints exhibited increase trho relaxation times compared non regions furthermore regions cartilage sgag content aggregate modulus decreased percent degraded collagen water content increased joints synovial fluid concentrations sgag decreased concentrations increased compared healthy joints trho relaxation times negatively correlated cartilage synovial fluid sgag concentrations aggregate modulus positively correlated water content permeability additionally demonstrated application vitro findings study human subjects specifically demonstrated walking results decreased trho relaxation times consistent water exudation increase proteoglycan concentration vivo loading together findings demonstrate cartilage imaging synovial fluid biomarkers provide powerful non invasive tools characterizing changes biochemical biomechanical environments joint elsevier ltd rights reserved
background among adolescent pregnancies unintended greater use highly effective contraception reduce unintended pregnancy although multiple studies discuss adolescent contraceptive use consensus regarding use long acting reversible contraception first line contraception option objective performed systematic review medical literature assess continuation long acting reversible contraceptives among adolescents study design ovid medline cochrane databases embase databases searched using key words relevant provision long acting contraception adolescents articles published january august selected inclusion based specific key word searches detailed review bibliographies inclusion articles must provided data method continuation effectiveness satisfaction least long acting reversible contraceptive method participants months long acting reversible contraceptive methods included intrauterine devices etonogestrel implant studies english language included guidelines systematic reviews clinical reviews examined additional citations relevant points discussion articles initially identified selected full review articles met criteria inclusion studies selected full review extracted multiple reviewers inclusion determined consensus among authors studies similar outcomes forest plots combined effect estimates created using random effects model meta analysis observational studies epidemiology guidelines followed primary outcomes measured continuation method months expulsion rates intrauterine devices results review included studies including retrospective cohort studies prospective observational studies randomized controlled trial studies included women age years intrauterine device users implant users month continuation long acting reversible contraceptive device confidence interval intrauterine device continuation confidence interval implant continuation confidence interval among postpartum adolescents month long acting reversible contraceptive continuation rate confidence interval pooled intrauterine device expulsion rate confidence interval conclusion adolescents young women high month continuation long acting reversible contraceptive methods intrauterine devices implants offered adolescents first line contraceptive options
community editing effective tool improving contributions peer production communities like wikipedia question answer communities however mechanisms behind edits well understood previous studies focused effectiveness editing emergent hierarchies editing communities unknown editing executed system contains gamified motivations contributing edits paper examine participants editing unfit questions stack overflow large computer programming community combination community reputation system dynamics unfit questions allows examine different actors behave find early edits come high reputation users participate questioner answerer indicating users work retain certain questions results suggest high reputation user actions used identify bad questions archival quality
gender central axis around transformation radical right forces taking place new type movement emerging excessively masculine latvia experiencing increase women participation radical right latvian national front lnf vivid example development lnf influenced jean marie pen national front whose representatives visited latvia article provides detailed look women participation lnf nuanced view activities although gender equality issues priority right wing radical movements increased participation women socio political developments women increased financial independence changed gender proportion radical movements traditional gender roles lnf case suggests relations gender radicalism dynamic contextual determining factor lnf attitude towards gender issues idea woman mission explained lens esotericism
paper focuses problem probabilistic optimal day ahead scheduling energy resources active distribution networks adns resources include dispersed energy storage systems desss volatile renewable embedded generators technical constraints related energy resources electrical network modeled taken account proposed optimization problem paper first proposes convex formulation specific optimal power flow opf used compute resources schedule objective function aims achieving minimum following quantities network desss losses energy cost imported external grid deviations day ahead scheduled power flow external grid addition ability using substation transformer tap changer incorporated problem suitable cost function initial opf formulation enhanced thanks use mixed integer second order cone programming approach order formulate stochastic opf uncertainties problem due forecast errors generation load consumption energy prices applicability effectiveness proposed scheduling approach tested using modified version ieee buses test feeder
paper propose innovative approach enables two users manipulate object collaboratively goal benefits wide variety todays devices therefore solution based asymmetric collaboration pattern different scales users benefit suited points views interaction techniques according device setups indeed user application adapted thanks plasticity mechanisms system provides efficient way manipulate object within irregular narrow courses taking advantages asymmetric roles synchronous collaboration moreover aims provide way maximize filling courses object moves path
paper presents flexibility technology fpga implementation automatic control systems digital structure level hardware regulator action designed built vhdl standard also java graphical interface developed monitoring control experiments performed mechanism position control consisting motors encoder checking agile response different reference values graphing results embedded java application real time
three factor design varying aggressive behavior subtraits physical aggression low high hostility low high exposure film content innocuous violent imagery respondents exposed film segments thereafter engaged teaching task involved administration noxious feedback unproductive efforts learner display informed respondents intensity delivered feedback instructions provide feedback often required intensities deemed appropriate however respondents also told refrain using extremely high intensities intensities would hurtful learner none three independent variables exerted appreciable influence frequency use recommended feedback contrast frequency use disallowed hurtful feedback markedly affected independent exposure film content men scoring high hostility used impulsive aggressive responses frequently men scoring low subtrait within subtrait physical aggression however degree trait manifestation proved inconsequential impulsive aggression exposure violent film segment resulted frequent use impulsive aggressive responses exposure innocuous film segment elsevier inc rights reserved
effects exogenously added cacl photopigments photosynthetic evolution antioxidative enzyme activity membrane damage expression two heat shock genes groel groes apoptotic features anabaena heat stress degrees investigated heat stress lowered level photopigments however supplemented cultures showed low level reduction chl induced accumulation carotenoids phycocyanin heat stress photosynthetic evolving capacity maintained higher level cells supplemented medium among antioxidative enzymes superoxide dismutase activity unaffected presence absence contrast increases catalase ascorbate peroxidase glutathione reductase activities cells grown supplemented medium lower levels lipid peroxidation recorded anabaena cells grown supplemented medium comparison cells deprived medium target cells grown deprived medium developed apoptotic features early stages heat shock application seemed interfere apoptosis cells showed features heat exposure indicating role maintaining cell viability heat stress also continuous regulation two important heat shock genes groel groes supplemented cultures exposed heat shock indicating role stress management elsevier gmbh rights reserved
ankle bracelets anklets imposed law track convicted individuals used many countries alternative overloaded prisons many different systems monitoring individuals wearing devices electronic anklet monitoring systems commonly detect violations circulation areas permitted holders spite able monitor individual localization systems identify grouping activities monitored individuals although kind event could represent real risk offenses planned individuals order address problem help monitoring systems able proactive approach paper proposes sensor data fusion algorithms able identify groups based data provided anklet positioning devices results proposed algorithms applied support risk assessment context monitoring systems processing performed using geographic points collected monitoring center result produces history groups members timestamps locations frequency meetings proposed algorithms validated various serial parallel computing scenarios correspondent results presented discussed information produced proposed algorithms yields better characterization monitored individuals adapted support decision making systems used authorities responsible planning decisions regarding actions affecting public security
weibull distribution discovered rosin rammler sperling bennett context particle measurement weibull found distribution little later investigating strength materials years finally showed distribution potential wide applications statistics however justify name used denote important probability distribution neutral technical name like powered exponential distribution might suitable paper discusses papers rosin rammler sperling bennett well weibull work
use electric generators convert solar energy seems next twenty years least good solution compared photo voltaic systems considering higher efficiency paper presents full design low medium power electric solar collector stirling engine driven electric generator solve four main issues optimization geometry dimensions parabolic solar concentrator thermal modeling heat receiver two rectangular coordinates sun tracking system choice appropriate stirling engine model electrical generator driving system designed specific weather conditions annual solar radiation characteristics transylvanian plateau
long noncoding rnas lncrnas transcripts low protein coding potential occupy large part transcriptional output roles include regulating gene expression epigenetic transcriptional post transcriptional level cellular homeostasis however lncrna studies still infancy functions vast majority lncrna transcripts remain unknown generally known function human nervous system largely relies precise regulation gene expression various studies shown lncrnas significant impact normal neural development development progression neurodegenerative diseases review focused recent studies associated lncrnas neurodegenerative diseases including alzheimer disease parkinson disease huntington disease amyotrophic lateral sclerosis als multiple system atrophy msa frontotemporal lobar degeneration ftld glaucoma glaucoma caused unexplained ganglion cell lesion apoptosis labeled chronic neurodegenerative disorder therefore discussed association lncrnas glaucoma well illustrate role specific lncrnas may provide new insights understanding etiology pathophysiology neurodegenerative diseases mentioned
objective present work evaluate whether oral intake resveratrol ameliorates overactive bladder high fat fed mice male cbl mice fed standard chow high fat diet induce obesity received two week therapy resveratrol given daily gavage weight metabolic profile together cystometry vitro bladder contractions evaluated measurements gpphox sod mrna expressions reactive oxygen species ros bladder tissues serum tbars performed obese mice exhibited increases body weight epididymal fat mass significantly reduced oral treatment resveratrol cystometric study obese mice showed increases non voiding contractions post voiding pressure voiding frequency reversed resveratrol treatment likewise vitro bladder overactivity response electrical field stimulation carbachol normalized resveratrol gpphox sod mrna expressions bladder tissues markedly higher obese mice compared lean group addition ros levels bladder tissues serum lipid per oxidation tbars assay markedly higher obese compared lean mice reduced resveratrol treatment lean group resveratrol effect parameter evaluated results show two week therapy obese mice resveratrol reduces systemic bladder oxidative stress greatly ameliorated cystometry alterations vitro bladder overactivity resveratrol treatment could option prevent obesity associated overactive bladder elsevier rights reserved
introduction clomiphene citrate employed label men low testosterone restoration sperm counts men used exogenous testosterone clomiphene mixture two diastereoisomers zuclomiphene enclomiphene evaluated enclomiphene citrate men secondary hypogonadism aim aim compare oral enclomiphene citrate alternative topical testosterone main outcome measures blood levels total testosterone estradiol follicle stimulating hormone fsh luteinizing hormone sex hormone binding globulin thyroid stimulation hormone prolactin insulin like growth factor igf measured certain times treatment agent sperm parameters determined visits free testosterone calculated methods proof principle randomized open label fixed dose active control two center phase iib study men secondary hypogonadism treated previously topical testosterone results discontinuation topical testosterone morning values averaged months significant rise men receiving enclomiphene citrate gel sustained months months levels groups receiving gel enclomiphene citrate respectively men enclomiphene citrate group demonstrated increased fsh decreased one month posttreatment pretreatment values enclomiphene citrate elevated sperm counts seven seven men months six six men months sperm concentrations range gel ineffective raising sperm counts five men months raised counts two five men months follow enclomiphene citrate treatment associated elevated sperm counts conclusions enclomiphene citrate increased testosterone sperm counts concomitant changes fsh suggest normalization endogenous testosterone production restoration sperm counts hypothalamic pituitary testicular axis
manufacturing engineering important task assess conformance manufactured part design specification task usually carried measuring manufactured part using coordinate measuring machine provide set coordinate data software used fit design surface data closeness data fitted surface examined determine manufactured part within tolerance result process strongly depends correctness software used fitting validate software one often uses pre generated reference datasets reference dataset associated reference solution compared solution returned software test referred test solution real world applications datasets represented stored using finite numbers digits using finite precision software test processes dataset test solution generally differs reference solution paper present method determining numerical uncertainty reference solution used comparison test solution reference solution results applying method fitting data geometric elements presented
present instrumentation results spectroscopic remote sensing atmospheric levels based recording spectra visible solar radiation scattered zenith sky carried central part petersburg data obtained qualitatively agree results simultaneous analogous measurements suburb petersburg petrodvorets also data closest satellite measurements
result application technique multistep processes stochastic models construction range models implemented self consistent differential equations obtained partial differential equations master equation fokker planck equation stochastic differential equations langevin equation however analytical methods always allow research equations adequately proposed use combined analytical numerical approach studying equations purpose numerical part realized within framework symbolic computation recommended apply stochastic runge kutta methods numerical study stochastic differential equations form langevin approach program complex basis analytical calculations metasystem sage developed model verification logarithmic walks black scholes two dimensional model used illustrate stochastic predator prey type model used utility combined numerical analytical approach demonstrated
commissions inquiry frequently used venue alteration mechanisms investigate depoliticize local government reforms application leadership identity framework examines judgments commission chairs make course inquiry article explores roles commission chairs play interpretive authorities judgments commission chairs make scope stakeholder engagement whether adjust agenda inquiry generate four types leadership identity conservator consolidator advocate catalyst leadership identity framework applied two commissions conducting inquiries proposed structural reform local government two subnational systems northern ireland new south wales application framework reveals commission process leads shift conservator consolidator leadership identity systems despite different distinctive historical social political contexts
voices mothers color affected child welfare system typically marginalized largely left unheard yet attending experiences may yield wealth strategies system change women change path avoid child welfare system involvement altogether using augmented qualitative analytic methods two phenomenological studies utilized life histories approach current study lifts voices women color past child welfare involvement foster youth many mothers study findings highlight experiences within two broad themes immense insecurity resilience across domains lives child welfare affected women mothers study share insights aftermath complex trauma substance abuse within families particularly relational housing financial insecurity wreaked well garnered resilience perseverance faith empathy establishing stable homes implications practice policy future research discussed published elsevier ltd
one crucial issues regarding storm sewer system ability avoid sediment depositions pipe invert study mean flow velocity limit sediment deposition conditions partially filled circular storm sewers evaluated use support vector machine svm model coupled firefly algorithm ffa aforemetioned velocity defined velocity limit deposition parameters upon depends nondimensionalized using buckingham theorem therefore dimensionless parameters identified six different functional relationships terms dimensionless groups obtained effects functional relationships dimensionless velocity limit deposition defined densimetric particle froude number limit deposition analyzed using respectively svm ffa model svm model genetic programming model artificial neural network ann model five statistical indices used evaluating performance model training test phases later comparing performance different models finally predicted densimetric particle froude number values obtained proposed svm ffa model compared obtained three different dimensionless equations velocity limit deposition results indicate svm ffa predicts densimetric particle froude number limit deposition fairly accurately american society civil engineers
number european countries germany austria switzerland czech republic finland etc use resonant earthed system effectiveness arc suppression coils closing events network improved improvement automated control systems arc suppression coils task realized use mathematical models electrical network arc suppression coils adequately reflecting processes results presented paper aimed improving accuracy simulation radial network steady state mode arc suppression coils based asymmetry power lines mathematical model used detailed analysis steady state modes radial network arc suppression coils model includes assessment voltage quality indicators arcing validation arc suppression coils adjustment formation reliable initial conditions calculating overload single phase earth faults
background glycogen synthase kinase gsk inhibition lithium well established vitro proof biochemical effect mediates lithium beneficial action patients bipolar disorder lacking studied whether lymphocyte gsk activity measured indirectly lithium valproate vpa treated euthymic patients bipolar disorder different controls methods lymphocyte total ser phospho gsk inactive levels measured western blotting forty seven patients bipolar disorder age sex matched control subjects studied results significant differences found lithium vpa treated patients controls phospho gsk total gsk ratio conclusions data support concept vivo chronic treatment bipolar illness gsk inhibited either lithium vpa
reliance sales taxation increased states counties study aggregated county level data empirically explored associations state local sales taxes economic activity industry types county governments period results revealed negative associations sales tax rates economic activity especially manufacturing industry findings provided spatial dependence economic activity across counties form possible spillover study suggests policymakers pay attention manufacturing retail industries respond changes sales tax rates business activity
objectives suboptimal sleep duration considered increase risk stroke incidence thus aimed conduct dose response meta analysis examine association sleep duration stroke incidence methods searched pubmed web science cochrane library identify prospective studies evaluating association sleep duration nonfatal fatal stroke incidence restricted cubic spline functions piecewise linear functions used evaluate nonlinear linear dose response association results included total prospective studies enrolling participants stroke events nonlinear dose response meta analysis showed shaped association sleep duration total stroke lowest risk observed sleeping considering people sleeping reference long sleepers higher predicted risk total stroke short sleepers pooled risk ratios confidence intervals nonlineanty short sleep durations significantly associated nonfatal stroke total stroke subgroups structured interview non asian countries additionally found slightly decreased risk ischemic stroke among short sleepers piecewise linear trends compared every increment sleep duration led increase pooled risk ratios confidence intervals risk total stroke conclusion nonlinear piecewise linear dose response meta analyses long sleep duration significantly increased risk stroke incidence elsevier rights reserved
paper presents development validation implementation innovative comprehensive project performance metric specifically developed architecture engineering construction aec projects project quarterback rating pqr combines key performance metrics project single number provide basis quantifying project success combined performance areas include customer relations schedule budget compliance quality safety statistics financial metrics communication among different project stakeholders existing literature analyzed identify key performance metrics data collection instrument developed used gather quantitative performance data recently completed projects data collected industry professionals across united states multivariate data analysis techniques used validate model pqr compare overall performance different aec projects addition performance various project delivery systems paper pqr scores calculated projects completed different delivery systems results clearly show differences performance projects delivered design bid build dbb construction management risk cmr design build integrated project delivery ipd paper offers three major contributions construction engineering management literature presents development validation comprehensive performance model provides first comparison project delivery systems single comprehensive metric offers evaluation emerging ipd system demonstrating superior overall performance compared delivery systems american society civil engineers
insulation failure large industrial motor stator winding occur due electrical stresses generated transient voltages voltage distribution motor winding transient wave impulse type steep fronted type non linear consequently turns stressed others thus higher probability failure turns highly stressed estimation turn turn turn ground voltages done considering motor system equivalent electrical network aim paper evaluate internal voltage distribution winding due changes capacitance self inductance well mutual inductances voltage magnitude application impulse voltage terminal paper one industrial motor winding modeled simulated electro magnetic transient program emtp voltage distribution along first coil inter turn voltage distribution presented incoming wave standard non standard shapes
background flux analyses including flux balance analysis fba metabolic flux analysis mfa offer direct insights cell metabolism widely used characterize model non model microbial species nonetheless constructing mfa model performing flux calculation demanding new learners require knowledge metabolic networks carbon transitions computer programming facilitate standardize mfa modeling work set publish user friendly programming free platform wuflux flux calculations matlab results constructed open source platform steady state mfa using guide graphical user interface design environment matlab built user interface allows users modify models based experimental conditions wuflux capable directly correcting mass spectrum data tbdms tertbutyldimethylsilyl methyltrifluoroacetamide derivatized proteinogenic amino acids removing background noise simplify mfa different prokaryotic species software provides several metabolic network templates including chemoheterotrophic bacteria mixotrophic cyanobacteria users modify network constraints analyze microbial carbon energy metabolisms various carbon substrates glucose pyruvate lactate acetate xylose glycerol wuflux also offers several ways visualizing flux results respect constructed network validate model applicability compared discussed flux results obtained wuflux mfa software also illustrated model constraints cofactor atp balances influence fluxome results conclusion open source software mfa wuflux user friendly interface easy modify templates available http www cmfa org http tang eece wustl edu tooldevelopment htm continue documenting curated models non model microbial species improving wuflux performance
electron beam induced current ebic model implemented technology computer aided design simulations model uses carefully designed charge carrier generation profile describes electron beam induces charge carriers semiconducting device drift diffusion equations solved determine resulting current simulation provides map ebic signal compared experimental profiles comparison used fit parameters surface recombination rate otherwise difficult fit completed devices additional experimental data fits obtained performing experiments different electron beam energies thereby generating carriers different depths sample experiments performed cross sections silicon photodiodes varying surface preparations strong influence surface preparation method charge carrier diffusion observed
valerie andrews reviews artemis indomitable spirit everywoman jean shinoda bolen recent contribution feminine psychology bolen views artemis atalanta emerging role models noting popular culture embraced new brand heroine one fiercely committed cause motto never give never give artemis bolen invokes stories artemis atalanta illuminate gains feminist movement shifting gender roles well woman drive protect disenfranchised act advocate others result compelling portrait women activists today contrasts models feminine development exemplified myth psyche review highlights shifts women represented archetypally time illuminated bolen many books well reviewer experiences grassroots women movements women sports writing film workshops professional women life transition
biologic drugs infliximab anti tumor necrosis factor monoclonal antibodies transformed treatment immune mediated inflammatory conditions crohn disease ulcerative colitis collectively known inflammatory bowel disease ibd however complex manufacturing processes involved producing drugs mean use clinical practice expensive recent impending expiration patents several biologics led development biosimilar versions drugs aim providing substantial cost savings increased accessibility treatment biosimilars undergo expedited regulatory process involves proving structural functional biological biosimilarity reference product also expected clinical equivalency comparability demonstrated clinical trial one sensitive population requirements fulfilled extrapolation biosimilar approval indications approved permitted without need clinical trials long scientifically justifiable however justification requires mechanism action question similar across indications also comparable biosimilar clinically tested population likewise pharmacokinetics immunogenicity safety similar across indications comparable biosimilar clinically tested population date anti tumor necrosis factor biosimilars tested trials recruiting patients rheumatoid arthritis concerns raised regarding extrapolation clinical data obtained rheumatologic populations ibd indications review discuss issues surrounding indication extrapolation focus extrapolation ibd
standard economic theory presumes invariant preferences refute presumption chronobiological grounds documenting impact seasonal affective disorder investors demand initial public offerings ipos found seasonal mood substantially influences short long run ipo performance examining ipo first trading days indicates short run stocks issued short decreasing photo periods days associated depressing daylight conditions earn lower returns stocks issued long increasing photoperiods cheerful days quarter year stocks cum initial returns equated implying short run initial excess returns stocks issued cheerful periods fully absorbed subsequent performance long run stocks issued cheerful periods continue underperform year half subsequently years possibly revert grand average ipo underperformance average initial return differential ipos issued depressing cheerful days sizable order offering approaching relatively less publicly exposed firms assessed using database ipos average gross proceeds million
amount quality energy converted photovoltaic system connected grid evaluated experimental monitoring computer simulation solar energy laboratory ufrgs developed simulation software analysis grid connected photovoltaic systems fvconect order perform reliable simulation required implementation suitable mathematical models describe behavior system component inverter equipment responsible converting manufacturers provide technical parameters inverters however electrical thermal characteristics require mathematical models coefficients must obtained specific tests work presents methodology analysis thermal behavior inverters analysis requires experimental determination two thermal coefficients energy losses due inverters overheating calculated proposed methodology providing accurate simulation determined photovoltaic system proposed methodology tested several inverters providing good results
capnography end tidal carbon dioxide etco monitoring variety uses pediatric intensive care setting ability continuously measure exhaled carbon dioxide provide vital information airway breathing circulation critically ill pediatric patients capnography diagnosis specific applications pediatric patients congenital heart disease reactive airway disease neurologic emergencies metabolic derangement modality allows noninvasive monitoring become standard care article reviews basic principles clinical applications etco monitoring pediatric intensive care unit
cryptographic algorithms secret keys generated randomly security system depends key therefore generation random sequences vital randomness testing done means statistical randomness tests work show probabilities overlapping template matching test nist test suite valid specific template need recalculated templates calculate exact distribution bit templates propose new randomness tests namely template matching tests new tests applied sequence minimum length whereas overlapping template matching test nist test suite applied sequences minimum length moreover apply proposed tests biased nonrandom data observe new tests detect nonrandom behavior generator even bias whereas template matching tests nist detect bias
providing optimal mechanical ventilation critically ill children remains challenge patient ventilator dyssynchrony results frequently numerous deleterious consequences patient outcome including increased requirement sedation prolonged duration ventilation greater imposed work breathing currently used ventilators real time continuously displayed graphics pressure volume flow versus time scalars well pressure flow versus volume loops clear understanding graphics provides lot information mechanics respiratory system patient ventilator interaction dynamic fashion using information facilitate tailoring support provided manner provided best suit dynamic needs patient paper starts description scalars loops followed discussion information obtained graphics review follow common types dyssynchronous interactions detected ventilator graphics final section discusses graphics used optimize ventilator support provided patients
nowadays open archive information system oais model widely adopted hospitals manage data related doctors patients however archival storage systems hospitals typically based old relational database management systems rdbms makes hard management patients data especially health level format fact data continuously parsed order stored relational databases sent hospital systems considering also interoperable scenarios data continuously grow management patients information become hard paper discuss oais system able manage big data particular considering case study glucose observations json format demonstrate scalable scenario archival storage big data processing convenient hospitals traditional archival storage systems
monolayer expansion generated great interest model system study collective cell migration expansion culture front often develops fingers recently modeled using proposed feedback curvature monolayer leading edge outward motility edge cells show model able explain puzzling observed increase collective cellular migration speed monolayer expanding thin stripes well describe behavior within different confining geometries recently observed experiments comparisons give support model emphasize role played edge cells edge shape collective cell motion
atmospheric corrosion behavior aluminum alloy exposed industrial marine atmosphere environments months investigated weight loss test tensile strength test ray photoelectron spectroscopy xps scanning electron microscope sem optical microscope results weight loss tensile strength showed compared industrial atmosphere environment presented higher corrosion susceptibility marine atmosphere environment xps analysis indicated major constituents corrosion products formed industrial atmosphere environment aluminum hydroxide aluminum oxide aluminum sulfate marine atmosphere environment corrosion products mainly contained aluminum chloride aluminum hydroxide aluminum oxide surface morphologies analysis revealed corrosion products formed industrial atmosphere environment agglomerated uneven corrosion products formed marine atmosphere environment presented polygon shape revealed broad cracks cross section morphologies analysis manifested suffered pitting attack types atmosphere environments intensity pitting attack marine atmosphere environment much serious industrial atmosphere environment
depending two dimensional structure woven geotextiles analytical solutions proposed predict pore size characteristics woven slit film geotextiles certain uniaxial tensile strains strained per cent open area poa equivalent pore size expressed functions tensile strain physical properties woven geotextiles mass per unit area geotextile density size slit films used predicting strained pore size characteristics woven slit film geotextiles influence uniaxial tensile strain pore size characteristics two woven slit film polypropylene geotextiles evaluated image analysis several pore size parameters corresponding different strains measured including poa pore size distribution psd comparison made analytical experimental results experimental data previous studies used confirm validity analytical solution addition image analysis results show poa increase uniaxial tensile strain psds move towards direction large open sizes increasing levels stain elsevier ltd rights reserved
aim randomized pilot study investigate effects short training programme loving kindness compassion meditation lkm patients borderline personality disorder patients allocated lkm mindfulness continuation training control group patients lkm group showed greater changes acceptance compared control group remarkable changes borderline symptomatology self criticism self kindness also observed lkm group mechanistic explanations therapeutic implications findings discussed highlights three weeks loving kindness compassion meditations increased acceptance present moment experience patients borderline personality disorder significant improvements severity borderline symptoms self criticism mindfulness acceptance self kindness observed lkm intervention lkm promising complementary strategy inclusion mindfulness based interventions dialectical behavioural therapy treating core symptoms borderline personality disorder copyright john wiley sons ltd
paper describe novel proposal field smart cities using ontology matching algorithm guarantee automatic information exchange agents smart city smart city composed different types agents behave producers consumers information smart city proposal data context obtained sensor device agents users interact smart city means user system agents knowledge agent well smart city knowledge semantically represented using different ontologies open city fully accessible agent therefore provide enhanced services users need ensure seamless communication agents city regardless inner knowledge representations ontologies meet goal use ontology matching techniques specifically defined new ontology matching algorithm called ontophil deployed within smart city never done ontophil tested benchmarks provided well known evaluation initiative ontology alignment evaluation initiative also compared matching algorithms although algorithms specifically designed smart cities additionally specific tests involving smart city ontology different types agents conducted validate usefulness ontophil smart city environment
double sided liquid cooling yag disk oscillator working pump repetition rate demonstrated output energy realized corresponding opticaloptical efficiency slope efficiency pump pulse width laser pulse width instead damped signal output laser comprises undamped spikes periodic intra cavity loss found numerical analysis frequency component near eigen frequency relaxation oscillation resonance effect induce amplified spikes even though loss fluctuates small range shark hartmann sensor used investigate wavefront aberration induced turbulent flow temperature gradient according wavefront fluid mechanics analysis considered periodic intra cavity loss attributed turbulent flow temperature gradient
trends higher education indicate women earning advanced degrees men male students female concentrated programs experience barriers academic success study investigated male graduate students experience female concentrated university four focus groups participants conducted mid atlantic university united states data analyzed using grounded theory methodology participants identified wide range masculinity norms focused academic pursuits tied fulfilling traditional gender roles worker provider breadwinner traditional gender norms pursuit status achievement oriented participants experienced academic support faculty peers tied sense connection specific academic program perceived academic support programmatic connection contributed desire stay university complete degree practical considerations close graduation high cost transferring also reported factors retention current research suggests aspects traditional masculinity high academic motivation may linked male graduate students suggestions future research potential programmatic implications male students female concentrated university considered
electronic countermeasure ecm attack emerging threat radar network recent years necessary design secured radar network ecm attack paper prove radar network conventional measurement fusion schemes insecure deceptive ecm decm attack new measurement fusion scheme proposed shows better security performance decm attack happens numerical simulations presented demonstrate effectiveness proposed measurement fusion scheme copyright john wiley sons ltd
paper class fast adaptive fourier based transforms used spectroscopic data compression transforms based adaptive modification cooley tukey signal flow graph adaptive versions cosine cosine haar cosine walsh transform various degrees taken base experiments transform kernels modified according reference vectors representing given class processed data results obtained using transforms gamma gamma ray coincidence spectra compression presented compared results obtained use classical transforms classical adaptive transforms used line well line compression elsevier rights reserved
background hydroxyurea among commonly used cytoreductive treatments polycythemia vera previous research clinical experience suggest patients respond optimally consistently durably treatment study investigated patterns use impact disease control among patients real world clinical practice united states methods oncologists hematologists recruited april july reported data patient charts treatment history disease symptom comparisons subgroups performed using chi square tests one way analyses variance categorical continuous variables analyses performed using descriptive statistics results overall physicians participated provided data patients male mean age years mean time since diagnosis years patients stopped common reasons discontinuation assessed treating clinician inadequate response intolerance disease progression among patients currently significant proportion elevated blood cell counts hematocrit values platelet levels wbc counts two thirds patients elevated count elevated counts counts elevated common related signs symptoms among patients fatigue splenomegaly conclusions although many patients benefit therapy continue suboptimal control disease evidenced persistence abnormally elevated blood cell counts continued experience disease related manifestations signs symptoms data denote significant medical need patients currently previously treated
switched reluctance machine srm offers advantages topologies low torque density high torque ripple use non standard power converter limitations paper develops drive configuration facilitates operation six phase srm using standard three phase inverter order address limitations focus paper investigation electromagnetic design aspects two candidate srm topologies six phase context pure electric hybrid electric vehicle type application advances made understanding electromagnetic design suitable srms conventional srm demonstrated preferred topology parametric fea design studies reference given specification initial laboratory test results prototype machine presented demonstration drive concept verification machine design
heart rate measurements based camera visible light used detect non contact mode great application prospects clinical application home health care however cmos sensors equipped rolling shutters distinguishes different lines per frame become light sensitive different moments time stylized dithering image acquisition imaq time caused different computer programs running background greatly influence accuracy measured paper analyze phase error caused cmos sensor system error introduced system sampling clock jitters according derivation propose two methods amplitude frequency superposition cubic spline interpolation reconstruction method based actual schedules widely utilized computer vision overcome camera phase error sampling time fluctuation error amplitude signal analyzed processed amplitude frequency domain method amplitude frequency superposition ignores signal phase thus eliminate phase error effectively cubic spline interpolation reconstruction method based actual schedules reconstructed non uniform sampling images uniform ones eliminate system error involved system clock jitters properties methods tested applying simulation experiments real measurements simulation amplitude measured signal improved relative amplitude measured without method amplitude frequency superposition root mean square error signal frequency detected cubic spline interpolation reconstruction method based actual schedules reduced real measurements amplitude raised relatively based amplitude frequency superposition accuracy raised approximately method cubic spline interpolation reconstruction method based actual schedules therefore simulation experiments real measurement proof effectively eliminate camera phase error based amplitude frequency superposition extraction method cubic spline interpolation based timetable method effectively reduce random error imaq due system clock jitters methods widely used dynamic signal detection based machine vision
background nurse family partnership nfp home visiting program serving first time low income mothers area focus healthy early childhood development previous foundational trials program effect breastfeeding immunizations shown mix neutral positive results present evaluation investigates effects following program scale using large contemporary cohort clients methods nurse family partnership client breastfeeding immunization status compared national survey children health data national immunization survey data respectively sample differences demographic covariates adjusted using logistic regression results nurse family partnership clients significantly likely ever breastfed adjusted prevalence ratio apr maintain breastfeeding apr apr months less likely exclusively breastfeed months apr nfp clients significantly likely date immunizations apr apr apr months age reference cohort significant difference months discussion nurse family partnership clients beneficial breastfeeding immunization outcomes children mothers demographically similar profiles however exclusive breastfeeding months lags behind reference sample represents potential area improvement
several studies show connection religion prosociality saroglou investigate whether causal relationship two variables growing number scholars employed priming religious concepts measure influence prosocial behavior pichon boccato saroglou recent development religious priming ritter preston argued different primes agent prime spiritual abstract prime institutional prime may also varying influence prosocial behavior specifically helping ingroup outgroup target mind social categorization target help agent prime institutional prime spiritual prime experiment conducted directly investigate hypothesis results suggest priming religious concepts especially spiritual prime increase prosocial behaviors however significant effect found social categorization implies filipino participants elicit prosocial behavior regardless social categorization ingroup outgroup target help present study findings contribute literature religious priming influence prosocial behavior
absolutely secure communication implemented one time pad proposed shannon requires physical random numbers rates matched associated communication systems used secret keys wide application wdm technology optical communication single channel rate current digital communication system exceeded developed towards ensure absolute security large capacity communication large number real time secure random numbers needed secure random numbers commonly produced utilizing physical random phenomena called physical random number generators however conventional physical random number generators limited low bandwidth applied entropy sources thermal noise photon counting chaotic electrical circuits thus typical low bit rates order recent years chaotic lasers attracted wide attention due generation secure reliable high speed random number sequences due coherent merits high bandwidth large amplitude fluctuation ease integration lots schemes based laser chaos high speed random number generation execute random number extractions associated laser chaos electrical domain thus generation rates faced well known electrical bottleneck hand optical random number generation rng methods signal processes optical domain efficiently overcome rate limitation great potential generating ultrafast random numbers several dozens hundreds however experimental report realization rng one obstacles way rng achievement implement fast real time optical sampling entropy signals laser chaos paper present principal experimental demonstration feasibility optical sampling chaotic light signal constructing toad based optical sampler polarization independent semiconductor optical amplifier soa specifically experimentally generate chaotic laser signals using optical feedback semiconductor laser finally complete gsa real time high fidelity optical sampling chaotic laser bandwidth ghz experimental results show whether optical sampling period proportional external cavity feedback time great effect weak periodic suppression chaotic signal proportion weak periodicity original chaotic signal effectively eliminated favorable generation high quality physical random numbers best knowledge first time realize optical sampling chaotic signal experiments
background study aimed explore relationship body mass index bmi bone mineral density bmd lumbar vertebra femoral neck postmenopausal females material methods september september healthy postmenopausal females underwent physical examinations women children health care hospital linyi enrolled study subjects divided groups underweight group normal weight group overweight group addition age stratifications years old dpx type dual energy ray bone densitometry american lunar company used measure bmd lumbar vertebra femoral neck recruited subjects pearson test used correlation analysis results bmds scores lumbar vertebra femoral neck proximal femur ward triangle region among groups ranked follows underweight group normal weight group overweight group significant differences body weight bmi among underweight normal weight overweight groups scores examined anatomic locations showed significant differences underweight group normal weight group well underweight group overweight group scores lumbar vertebra significant differences normal weight group overweight group bmds anatomic components study showed statistical differences age stratifications overweight group underweight group well overweight group normal weight group stratified years old bmds lumbar vertebra showed statistical differences normal weight group underweight group various factors could ranked according absolute values correlation coefficients body weight bmi height age body weight bmi height positively correlated bmds examined anatomic locations however age negatively correlated various components body lumbar vertebra femoral neck proximal femur ward triangle region conclusions study provides evidence body weight bmi important factors affecting bmd postmenopausal females low bmi likely osteopenia likely develop osteoporosis bmi used important index prevent osteoporosis
thyroid disease neglected tropical disease common noncommunicable disease developing world overlooked diagnosed inadequately managed spectrum thyroid disorders developing world qualitatively different found industrialized countries qualitative difference resulted limited access clinical laboratory imaging resources necessary care patients thyroid disease management thyroid disease developing world comparable care provided disorders thyroid north america fifty years ago article reviews public health clinical aspects developing world medical surgical thyroid disease topics covered include iodine deficiency disorders congenital hypothyroidism goiter thyroid cancer hyper hypothyroidism review concludes description programs based smartphone technology improve availability affordability quality thyroid disease care
background adolescents obese high risk developing obstructive sleep apnea osa although clear evidence associating osa metabolic dysfunction adults evidence less clear cut adolescents purpose review determine association sleep apnea dyslipidemia insulin resistance cardiovascular disease risk nonalcoholic fatty liver disease difficulty weight loss adolescents methods systematic literature review using pubmed scopus cinahl google scholar psycinfo performed articles screened reviewed priori protocol results sixteen articles included qualitative synthesis included meta analysis results meta analysis indicate osa adolescents associated greater risk dyslipidemia insulin resistance hypertension conclusions although obesity leads increased metabolic risk osa appears independently increase metabolic impairment adolescents obesity frequently screened osa determine need treatment reduce metabolic burden
problem data representation fundamental efficiency search algorithms traveling salesman problem tsp computational effort required perform tour operations traversal subpath reversal considerably influence algorithm design performance propose new data structure level satellite tree representing tsp tour discussion properties framework general tour operations level satellite tree representation shown significantly efficient predecessors large scale instances
purpose purpose paper explore robustness emerging body knowledge collaborative supply chains context engineered order eto manufacturing engineering project systems design methodology approach paper uses evolutionary classification technique build evolutionary history industry case study french eto machine design industry findings evolutionary history shows collaborative forms governance used industry era failed transactional market based governance industry however abandoned collaborative forms governance return historical roots towards vertical integration research limitations implications findings relevant context investigated industry practical implications certain industrial settings managers consider promise collaboration trust cautious originality value data set supports williamson rejection trust mode governance calls careful delineation conditions recourse trust managerial situations
order reduce excessive longitudinal vibration suspension bridge induced vehicle braking forces one possible dynamic loadings earthquake excitations mixed control methodology using magnetorheological dampers developed study firstly corresponding preferred controls subjected vehicle braking forces earthquake excitations separately obtained simulation analyses seven control strategies mixed control system established obtain best control efficiency reduce energy consumption dampers based displacement responses changing rate accelerations finally system applied reduce longitudinal vibration responses pingsheng bridge numerical results show passive control semi active fuzzy control corresponding preferred controls subjected vehicle braking forces earthquake excitations respectively mixed control good agreement corresponding preferred controls four dynamic loadings including vehicle braking forces pingsheng bridge earthquake wave centro wave takochi oki wave verifies reliability effectiveness system mixed control good performance applicability different loading combinations composed vehicle braking forces earthquake excitations
evaluate effects mulching ridge furrow widths soil temperature moisture crop growth yield water use efficiency wue series field experiments conducted potato field inner mongolia china four treatments flat plot without mulching plastic film mulched ridge mrf plastic film mulched ridge furrow mrf non mulched conducted widths ridge furrow two additional non mulching treatments ridge furrow width ridge furrow width tested results indicated mulching practices increased topsoil temperature compared non mulching treatments emergence stage compared soil water storage furrows increased average mrf treatment respectively plant leaf area index dry biomass values potato growth stage also increased treatment produced greater effects crop productivity increased total yield marketable yield compared three non mulching treatments treatment produced highest total yield marketable yield compared wue total yield marketable yield increased respectively elsevier rights reserved
objective investigated year pregnancy rates emergency contraception users selected copper intrauterine device iud oral levonorgestrel lng study design prospective study followed women year choosing either copper iud oral lng study powered detect difference pregnancy rates within year presenting results women presented agreed participate trial met inclusion criteria chose copper iud chose oral lng iud group nulligravid iud insertion failed women year follow rate iud users contacted year still iuds place year cumulative pregnancy rate women choosing iud choosing oral lng hazard ratio confidence interval type method actually received corresponding values copper iud users oral lng users multivariable logistic regression model controlling demographic variables demonstrates women chose iud fewer pregnancies following year chose oral lng conclusion one year presenting women choosing copper iud half likely pregnancy compared choosing oral lng implications compared users choose oral levonorgestrel select copper iud lower rates pregnancy next year greater use copper iud may lower rates unintended pregnancy high risk women elsevier inc rights reserved
multimodal neuromonitoring neurocritical care increasingly includes electrocorticography measure epileptic events spreading depolarizations spreading depolarization causes spreading depression activity isoelectricity electrically active tissue depression long lasting spreading depolarizations occur still isoelectric tissue activity suppressed spreading depolarizations termed isoelectric assumed indicate energy compromise however experimental clinical recordings suggest long lasting spreading depolarization induced depression isoelectric spreading depolarizations often recorded outside actual ischemic zones allowing remote diagnosis delayed cerebral ischemia aneurysmal subarachnoid hemorrhage analyzed simultaneous electrocorticography tissue partial pressure oxygen recording aneurysmal subarachnoid hemorrhage patients multiple regression showed peak total depression duration per recording day mean baseline tissue partial pressure oxygen independent predictors outcome moreover tissue partial pressure oxygen preceding spreading depolarization similar differences tissue partial pressure oxygen responses spreading depolarization subtle isoelectric spreading depolarizations spreading depressions supports similar clustering spreading depolarizations long spreading depolarization induced periods isoelectricity useful detect energy compromise remotely valuable exact location future developing pathology unknown time neurosurgeon implants recording devices
laminar radial flow two parallel disks fundamental nonlinear fluid mechanics problem described navier stokes equation unsolved exact solution found even extensive references unclear radial flow remains laminar high reynolds numbers paper first presents exact velocity distribution solutions developed radial inflows outflows proving flows described brief jacobi elliptic sine squared functions different characteristics inflow stable velocity distribution forms outflow velocity distribution may inflection point inducing flow instability separation velocity distributions become classic parabolic law low reynolds numbers uniform similar turbulent velocity distributions high reynolds numbers furthermore pressure boundary shear stress follow inverse square law friction factor invariant results instructive studying nonuniform open channel flow nonlinear inertia importance american society civil engineers
paper concerned parameter output estimation industrial processes described finite impulse response model presence randomly missing output measurements statistical models describing estimation problems given prior distributions unknown parameters variables constructed estimation problems incomplete dataset formulated variational bayesian framework problems randomly missing measurements overfitting high sensitivity parameter estimate noise handled simultaneously iterative formulas estimate posterior distributions missing output data unknown parameters based available process data derived simulation example hybrid tank system experiment performed demonstrate effectiveness proposed method
walking complex motor behavior special relevance clinical neurology many neurological diseases parkinson disease stroke characterized gait disorders whose neurofunctional correlates poorly investigated indeed analysis real walking standard neuroimaging techniques poses strong challenges studies motor imagery walking observation performed far functional near infrared spectroscopy fnirs becoming important research tool assess functional activity neurological populations special tasks walking allows investigating brain hemodynamic activity ecological setting without strong immobility constraints systematic review following prisma guidelines conducted fnirs based examination gait disorders twelve initial yield articles included review lesson learnt studies suggest oxy hemoglobin levels within prefrontal premotor cortices sensitive compensation strategies reflecting postural control restoration gait disorders although field study relative infancy evidence provided encourages translation fnirs clinical practice offers unique opportunity explore depth activity cortical motor system real walking neurological patients also discuss extent fnirs may applied assessing effectiveness rehabilitation programs
aims clinical relevance urethral pressure variations upv pathophysiology active bladder syndrome oab remained controversial date studies report association oab detrusor activity recently international consultation incontinence research society recommended new clinical research performed subject provide systematic review literature specify recommendation methods literature search performed pubmed embase web science cochrane central cinahl academic science premier science direct wiley online using sensitive search string combination authors independently reviewed scored full text papers consensus methodological quality obtained according oxford level evidence loe results four hundred eighty seven abstracts screened papers met predefined inclusion selection criteria incidence figures upv varied studies poor methodological quality oxford loe scores measurement methods techniques show large variety mentioned association oab upv however frequently reported conclusion exists phenomenon upv apart may separate entity within oab syndrome large variation measurement techniques patient populations hinders fundamental research well clinical progress clinical relevance upv consequences treatment therefore yet established future prospective research well defined patient population standardised urodynamic measurement techniques needed results standardized objective evaluations compared clinical signs symptoms validated questionnaires wiley periodicals inc
biogas could provide sustainable energy source wood fuels rural households sub saharan african however functioning biogas digesters limited areas low water availability water required approximately day cow day pig providing manure digester day person household using digester volume capita consider potential domestic water recycling rainwater harvesting aquaculture supply water needed digestion different countries sub saharan africa domestic water recycling found important every country usually insufficient meet requirements digester households countries need collect additional water rooftop rainwater harvesting also important role iron roofs effective thatched roofs collecting water however even iron roof size roof commonly found sub saharan africa small collect sufficient water requiring extra area person rainfall local market fish stocking pond tilapia fed plankton growing bioslurry digester could provide important source additional income hold water required digester areas rainfall low seasonal fishpond might stocked rainy season allowing pond covered dry period reduce evaporation evaporative losses exceed rainfall extra catchment area needed maintain water level pond equivalent approximately person household
extreme learning machine elm variants effective many machine learning applications imbalanced learning big data learning however unable solve imbalanced large volume data learning problems study addresses problem applications distributed weighted elm elm algorithm proposed based mapreduce framework confirm feasibility parallel computation first fact matrix multiplication operators decomposable illustrated improve computational efficiency improved elm algorithm idw elm developed using one mapreduce job successful operations proposed elm idw elm algorithms finally validated experiments
face high partial complete disk failure rates untimely system crashes executions low priority background tasks become increasingly frequent large scale data centers however existing algorithms reactive optimizations exploit temporal locality workloads reduce user requests low priority background tasks address problem paper proposes intelligent data outsourcing ido zone based proactive data migration optimization significantly improve efficiency low priority background tasks main idea ido proactively identify hot data zones raid structured storage systems normal operational state leveraging prediction tools identify upcoming events ido proactively migrates data blocks belonging hot data zones degraded device surrogate raid set large scale data centers upon disk failure crash reboot user requests addressed degraded raid set serviced directly surrogate raid set rather much slower degraded raid set consequently performance background tasks user performance background tasks improved simultaneously lightweight prototype implementation ido extensive trace driven experiments two case studies demonstrate compared existing state art approaches ido effectively improves performance low priority background tasks moreover ido portable easily incorporated existing algorithms raid structured storage systems
patients burn trauma risk infections caused antibiotic resistant bacteria abr subsequent increase morbidity mortality part swedish strategic program antibiotic resistance intensive care icu strama surveyed distribution species abr isolates patients admitted swedish burn center linkoping university hospital international comparison strama successful reducing antibiotic consumption among animals humans primary care aim study investigate antibiotic consumption pressure resistance rates swedish burn unit methods microbiology data total body surface area tbsa patient days mortality collected hospital database patients admitted burn center university hospital linkoping april december results total patients admitted mean annual admission rate patients range microbiology cultures approximately per patient collected study period positive approximately per patient annual mean total body surface area tbsa range annual mortality rate range mrsa incidence corresponds mrsa incidence admission days tad corresponding figures escherichia coli resistant generation cephalosporins esbl phenotype tad klebsiella spp esbl phenotype tad carbapenem resistant pseudomonas aeruginosa tad carbapenem resistant acinetobacter spp tad conclusions results show sustained low risk mrsa high although increasing risk carbapenem resistant aeruginosa elsevier ltd isbi rights reserved
widely accepted reinforcement made polyethylene polypropylene susceptible creep soil hydraulic conductivity varies void ratio however unfortunately available sensitivity analysis time dependent embankment behaviour taking either reinforcement viscosity time varying hydraulic conductivity subsoil consideration influence geosynthetic reinforcement viscosity decreasing hydraulic conductivity consolidation time dependent performance embankments floating columns investigated using fully coupled model embankment working height corresponding post consolidation polypropylene geotextile strain shown assumption constant hydraulic conductivity failure consider viscous behaviour geosynthetic reinforcement underestimate time dependent embankment deformations including differential crest settlement horizontal toe movement effects factors including foundation soil reinforcement stiffness column stiffness column spacing column type floating fully penetrating construction rate time dependent behaviour column supported embankments explored elsevier ltd rights reserved
present first phase behaviour study south australian nau nontronite clays exfoliated water orientation response varying magnetic fields also describe novel route grafting water soluble thermo responsive polymers onto edges nanoclay platelets
background direct oral anticoagulants doacs share many indications warfarin require less frequent follow monitoring limited data available prescribing doacs appropriate laboratory monitoring real world clinical setting objective determine patients receiving care university florida health internal medicine clinics prescribed doacs according food drug administration fda approved labeling secondary objectives determine percentage patients receiving appropriate baseline laboratory tests prior doac initiation frequency laboratory monitoring methods retrospective chart review evaluated patients enrolled health internal medicine practices within health system prescribed doac april april adherence fda approved dosing recommendations baseline laboratory tests compared previously published data study approved institutional review board results total patients met inclusion criteria ninety six patients doac prior data collection patients started doac data collection patients prescribed doacs per fda approved labeling obtained complete blood count serum creatinine liver function tests prior doac initiation conclusions prescribing practices significantly better published data however patients prescribed doac according fda approved labeling less half patients started doac obtained recommended labs prior medication initiation
online vector quantization method successfully applied kernel adaptive filters kafs curbing linearly growing radial basis function rbf network thereby generating family quantized kafs qkafs however existing qkafs based mean square error mse criterion actually good choice non gaussian signals paper new quantized kernel adaptive filter called quantized kernel maximum correntropy qkmc developed robust large outliers impulsive noises mean square convergence analysis qkmc conducted sufficient condition guaranteeing convergence therefore obtained filtering accuracy qkmc also proved higher representative quantized kernel least mean square qklms addition make full use information hidden input output spaces propose modified qkmc based bilateral gradient qkmc limit final network size qkmc qxmc fixed budget qkmc also developed simulation results cases gaussian non gaussian noises presented validate proposed qkmc qkmc qkmc elsevier inc rights reserved
structure represented one several oscillators couple one dimensional transmission environment vibrating string mechanical case lossless transmission line electrical case turned attractive research field complex structures complex behavior due fact structure represents generalization various interconnection modes lumped parameters oscillators hand lossless distortionless propagation along transmission lines generated several research electrical thermal hydro control engineering leading association functional differential equations basic initial boundary value problems present research performed crossroad aforementioned directions shall associate starting models functional differential equations cases neutral type make use general theorems existence stability forced oscillations functional differential equations challenges introduced analyzed problems general theory emphasized together implication results various applications
paper studies use usb interface achieve communication sunplus mcu ordinary personal computer design entire system aspects including circuit design protocol host computer programming design lower computer program driver program written using simple character signal transmission microcontroller computer done information transmitted successfully using usb protocol
objectives research role sport context acculturation young migrants mainly focused migrant populations considering acculturation two way process involving migrant host populations research investigating perspective hosts enhance understanding acculturation process purpose present study explore acculturation attitudes perceptions adolescents host population function sport participation furthermore adolescents participating sport role sport motivational climate relation acculturation attitudes investigated design method cross sectional quantitative design adopted participants girls greek high school students years age among girls athletes competing individual team sports participants completed measures acculturation attitudes athletes additionally completed measures motivational climate basic need satisfaction controlling coaching behavior results athletes scored higher non athletes attitudes towards multicultural contact analysis structural models revealed motivational climate characterized mastery climate supportive needs autonomy competence relatedness positively linked attitudes favoring migrants maintenance culture development interaction host culture whereas motivational climate characterized performance climate controlling coaching behavior negatively linked attitudes conclusion findings provide useful insights concerning perspectives host population regarding migrants acculturation role motivational climate play promoting integration elsevier ltd rights reserved
background acetylserotonin methyltransferase asmt enzyme converting melatonin melatonin catalyzes final reaction melatonin biosynthesis tryptophan metabolism pathway high expression asmt gene evident ppts presence abnormally high levels asmt pineal gland could serve indication existence pineal parenchymal tumors ppts brain neuropathol exp neurol different levels melatonin used trait marker prescribing mood disorders seasonal affective disorder bipolar disorder major depressive disorder addition melatonin levels also used calculate severity patient illness given point time methods seventy three melatoninergic inhibitors docked acetylserotonin methyltransferase order identify potent inhibitor enzyme chemical nature protein ligands greatly influence performance docking routines keeping fact view critical evaluation performance four different commonly used docking routines autodock vina gold flexx fred performed evaluation criterion based binding affinities docking scores experimental bioactivities results conclusion results indicated hydrogen bonding hydrophobic interactions contributed significantly ligand binding compound selected potent inhibitor minimum binding affinity maximum goldscore minimum flexx energy correlation value may useful selection correct docked complexes based energy without prior knowledge active site may lead understanding structures reliability biomolecular activity especially connection bipolar disorders
aim evaluate prevalence depression using different measures patients schizophrenia study relationship depression schizophrenia cognitive insight clinical insight disability socio occupational functioning methods total patients schizophrenia evaluated depression cognitive insight socio occupational functioning results patients included study one fourth found depression per mini international neuropsychiatric interview mini prevalence depression assessed calgary depression scale schizophrenia cdss hamilton depression rating scale hdrs depressive subscale positive negative syndrome scale panss respectively among different scales cdss highest concordance clinician diagnosis sensitivity specificity positive predictive value negative predictive value cdss also higher noted hdrs panss without depression per clinician diagnosis compared depression found significantly higher scores positive negative syndrome scale panss positive general psychopathology subscales panss total score participation restriction assessed scale lower level functioning assessed global assessment functioning gaf significant difference noted negative symptom subscale panss clinical insight assessed item panss disability assessed indian disability evaluation assessment scale ideas socio occupational functioning assessed social occupational functioning assessment scale sofs terms cognitive insight depression significantly higher score subscales self reflective self certainty subscales well mean composite index score conclusion results suggest one fourth patients schizophrenia depression compared hdrs panss cdss highest concordance clinician diagnosis depression presence depression related cognitive insight
oxygen vacancies play important role many photocatalytic reaction attracted enormous attention scientists engineers surface bulk oxygen vacancies different function photo reaction process herein three different tio nanoparticles possessing surface oxygen vacancies bulk single electron trapped oxygen vacancy setov fabricated dehydration reduction different titania precursors three kinds tio nanoparticles characterized systematically xrd tem raman xps esr vis drs techniques photocatalytic reduction results indicated bulk setovs surface oxygen vacancies contributed enhancement light absorption surface vacancies facilitated separation photo generated charge carriers contrast bulk setovs acted recombination center existence surface bulk oxygen vacancies exhibited synergistic effect improve photoreduction efficiency adjusting ratio surface bulk oxygen vacancies analyzing positron lifetime relative intensity positron annihilation photoreduction efficiency improved increase ratio surface oxygen vacancies bulk setovs elsevier rights reserved
paper describes main features state art monte carlo solver radiation transport implemented within coolfluid world class open source object oriented platform scientific simulations monte carlo code makes use efficient ray tracing algorithms axisymmetric arbitrary unstructured meshes described detail solver accuracy first verified testcases analytical solutions available validated space entry flight experiment fire comparisons experiments reference numerical solutions provided flexible design physical models ray tracing parallelization strategy fully reusing mesh decomposition inherited fluid simulator implementation made efficient reusable program summary program title coolfiuid catalogue identifier aezg program summary url http cpc qub summaries aezg html program obtainable cpc program library queen university belfast ireland licensing provisions gnu general public license version lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language computer desktops large hpc distributed systems operating system mac linux code vectorized parallelized parallelized mpi ram depending problem size megabytes several gigabytes classification external routines mpi boost petsc parmetis cmake nature problem radiative processes play fundamental role countless science engineering contexts including combustion astrophysics atmospheric space entry experiments plasma facilities shock tubes arc jets problem interested computation radiative heat transfer arbitrarily complex geometries particular characterize thermal loads acting surface space vehicles solution method code implements flexible efficient monte carlo algorithm making use state art ray tracing techniques designed validated arbitrary unstructured meshes code organized collection dynamically linked libraries connected computational kernel open source coolfluid platform monte carlo method parallelized mesh decomposition reusing partitioned mesh associated data structures fluid dynamics equations solved unusual features radiation transfer code coolfiuid offers unique combination ray tracing algorithms suitable handling axisymmetric simulations arbitrary unstructured grids parallelization strategy scalable based domain decomposition overall object oriented design allows easy integration new models algorithms plugged dynamically self registration techniques additional comments code part much larger set coolfluid libraries fully available github https github com andrealani coolfiuid include multiple numerical solvers physico chemical models processing algorithms interfaces third party scientific software cpc distribution also includes state art fully implicit finite volume solver euler navier stokes systems used produce flow solution radiative transport algorithm described paper aerothermodynamic solver used final testcase fireii paper based core finite volume modules different physico chemical radiation models latter made available cpc library since rely third party libraries mutation version parade version distributed due nda distribution file program mbytes therefore delivered directly download email requested instead html file giving details program obtained sent running time depending size computational grid number processors used running time vary seconds hours days testcases included version code using relatively small meshes run cpu cores user however totally free run cases different number cores less according convenience elsevier rights reserved
electrochemical properties alloy nanoparticles prepared arc discharge method studied nanoparticles serve anode materials ion batteries libs among alloy electrodes electrode best initial specific capacity maintains mah within cycles intermetallic compounds nanoparticles characterized thermodynamics analysis introduced elucidate energy balance formation mechanism electrochemical behaviours various alloy nanoparticles different conclude present intermetallic compounds eventually determine lithium ion storage ability well cyclic stability lithiation delithiation process elsevier rights reserved
background cumulative burden importance cardiovascular risk factors changed past decades specifically obesity rates increased among younger people whereas cardiovascular health improved elderly little known regarding changes impacted incidence mortality rates heart failure therefore aimed investigate age specific trends incidence year mortality rates following first time diagnosis heart failure denmark methods included danish individuals years age first time hospital diagnosis heart failure data collected nationwide danish registries annual incidence rates heart failure year standardized mortality rates calculated assumption poisson distribution results identified individuals first time diagnosis heart failure annual incidence rates per person years declined among older individuals rates versus versus individuals years versus individuals years versus individuals years increased among younger versus individuals years versus individuals years versus individuals years proportion patients incident heart failure years age doubled sex age adjusted incidence rate ratios versus confidence interval years age confidence interval among individuals years increased among younger years individuals observations may portend rising burden heart failure community
piezoelectric fiber composite emerging smart material exhibits much broader applications traditional piezoelectric ceramics especially light weight curved structures piezoelectric fiber composites different fiber thickness volume fraction fabricated effects structural parameters different fiber thickness volume fraction strain properties actuation performance piezoelectric fiber composites investigated different excitation voltages frequency results indicated free strain tip displacement decreased increasing thickness piezoelectric fiber voltage applied free strain tip displacement composite fiber thickness epsilon respectively much higher composite fiber thickness piezoelectric fiber composites exhibited orthotropic actuation properties higher free strains larger fiber volume fraction longitudinal transverse free strains composites fiber volume fraction times magnitudes composites fiber volume fraction respectively transverse effect coefficient ratio transverse longitudinal free strains decreased fiber volume fraction decreased
purpose study determine modeling school classroom effects necessary estimating passage reading growth across elementary grades longitudinal data students classrooms reading first schools used study obtained progress monitoring reporting network maintained florida center reading research oral reading fluency orf assessed four times per school year five growth models varying levels data student classroom school estimated order determine structures necessary correctly partition variance accurately estimate standard errors growth parameters results illustrate modeling higher level clustering inflated lower level variance estimates cases led biased standard errors authors recommend practice including classroom cross classification school nesting predicting longitudinal student outcomes
backgroundin healthy individuals absorption fructose excess glucose solution enhanced addition glucose present study aimed assess effects glucose addition fructose fructans absorption patterns genesis gastrointestinal symptoms patients functional bowel disorders methodsrandomised blinded cross studies performed healthy subjects functional bowel disorder patients fructose malabsorption area curve auc determined breath hydrogen symptom responses six sugar solutions fructose solution glucose sucrose fructose fructose glucose fructan fructan glucose whole foods fructose foods containing fructose excess glucose given without additional glucose intake fermentable short chain carbohydrates fodmaps fermentable oligo monosaccharides polyols controlled resultsfor fructose solution study patients functional bowel disorders breath hydrogen reduced glucose added fructose compared fructose alone mean auc versus ppm respectively glucose effect breath hydrogen response fructans six healthy controls showed breath hydrogen patterns similar functional bowel disorders differences symptoms experienced addition glucose except nausea glucose added fructose fructose foods study glucose addition whole foods containing fructose excess glucose nine patients functional bowel disorders nine healthy controls significant effect breath hydrogen production symptom response conclusionsthe absence favourable response symptoms support concomitant intake glucose foods high either fructose fructans patients functional bowel disorders
introduction disturbances circadian rhythms sleep play important role various types mood disorders like major depressive disorder mdd bipolar depressive disorder bpd seasonal affective disorder sad malfunctioning scn pineal melatonin link suggested main cause disorders rhythm regulating factor hormone involved regulation sleep melatonin essential control mood behavior areas covered melatonin involvement various mood disorders reviewed based studies undertaken patients mdd bpd sad chemistry metabolism newly introduced antidepressant agomelatine melatonin receptor agonist htc antagonist brain areas involved mood regulation also discussed clinical role mood regulation agomelatine efficacy safety tolerability also reviewed expert opinion agomelatine melatonergic antidepressant rapid onset action shown effective various types mood disorders mdd bpd sad studies find superior common antidepressants ssris snris clinical use today agomelatine efficacy good tolerability safety profile suggest may become preferred antidepressant near future
study empirical metrics software source code predict performance verification tools specific types software metrics comprise variable usage patterns loop patterns well indicators control flow complexity extracted simple data flow analyses demonstrate metrics powerful enough devise machine learning based portfolio solver software verification show portfolio solver would hypothetical overall winner international competition software verification comp three consecutive years gives strong empirical evidence predictive power metrics demonstrates viability portfolio solvers software verification moreover demonstrate flexibility algorithm portfolio construction novel settings originally conceived comp construction works well comp considerably verification tasks comp considerably candidate verification tools
functional movement screen fms aimed assessing fundamental movements often used identify players injury risk purpose study determine whether fms used predict injuries veteran footballers aged years eighteen veteran football teams recruited prospectively followed months players years performed fms start study period players exposure hours injuries recorded difference fms overall score injured uninjured players significant points mann whitney test players scoring score mean found analyses potential risk factors suggest higher age lower body mass longer football career risk factors injuries findings study suggest suitability fms injury prediction veteran footballers limited
healthy sleep essential children cognitive behavioral emotional development however remarkably little known influence sleep disorders different memory processes childhood data could give deeper insight effect sleep developing brain memory functions relationship sleep memory changes childhood adulthood present study examined effect sleep disorder declarative non declarative memory consolidation testing children sleep disordered breathing sdb characterized disrupted sleep structure used story recall task measure declarative memory alternating serial reaction time asrt task assess nondeclarative memory task enables measure two aspects non declarative memory namely general motor skill learning sequence specific learning two sessions learning phase testing phase separated offline period sleep data showed children sdb exhibited generally lower declarative memory performance learning testing phase however sdb control groups exhibited retention previously recalled items offline period showed intact non declarative consolidation sdb group sequence specific general motor skill findings suggest sleep disorders childhood differential effect different memory processes online offline give insight sleep disturbances affects developing brain
chidamide new highly selective histone deacetylase inhibitor displaying significant single agent activity peripheral cell lymphoma ptcl little known synergistic effect chemotherapy purpose study explore synergistic effect molecular mechanisms combination doxorubicin ptcl cells found showed dose time dependent inhibition effects ptcl cell meanwhile synergistic effect significantly observed combination treatment lower drug concentration doxorubicin lower drug concentration induced weak apoptosis ptcl cells combination treatment doxorubicin promoted significant apoptosis combination treatment doxorubicin significantly changed mitochondrial membrane potential acetylated level resulting regulating dna damage protein gamma hax apoptosis proteins including cleaved caspase cleaved caspase cleaved parp regulating anti apoptosis protein bcl word doxorubicin could increase induced inhibition effects ptcl cells suggesting combination doxorubicin doxorubicin based chemotherapy drugs might new therapy approach ptcl patients elsevier ltd rights reserved
self avowed members counterculture often based west coast rocky mountain west eschewed critics stereotypical notions stoned indolent hippies struggled build alternative economic system rejecting corporate capitalism consumer acquisitiveness built new enterprises new institutions new organizational forms new practices gave proof possibility creating economically sustainable alternative lives practices especially building one home repairing one vehicle promised free practitioners working wages order afford consumer goods even diy culture often promoted traditional gender roles many counterculture attempts escaping employee consumer nexus failed short lived succeed outlining alternative approach production consumption continuing impact american capitalist development
paper presents novel method detect free surfaces particle based volume representation contrast particle based free surface detection methods perform surface identification based physical geometrical properties derived underlying fluid flow simulation proposed approach demands spatial location particles properly recognize surface particles avoiding even use kernels boundary particles identified hidden point removal hpr operator used visibility test method simple fast easy implement robust changes distribution particles even facing large deformation free surface set comparisons state art boundary detection methods show effectiveness approach good performance method also attested context fluid flow simulation involving free surface mainly using level sets rendering purposes
paper considers robust low rank matrix completion presence outliers objective recover low rank data matrix small number noisy observations exploit bilinear factorization formulation develop novel algorithm fully utilizing parallel computing resources main contributions providing two smooth loss functions promote robustness two types outliers namely dense outliers drawn elliptical distribution sparse spike like outliers small additive gaussian noise efficient algorithm provable convergence stationary solution based parallel update scheme numerical results show proposed algorithm obtains better solution faster convergence speed benchmark algorithms synthetic real data scenarios
seasonal affective disorder sad characterized recurrent depression occurring generally fall winter numerous pieces evidence indicate association sad decreased brain neurotransmitter serotonin system functioning tryptophan hydroxylase tph key rate limiting enzyme synthesis brain paper concentrates relationship tph activity mood disturbances association human tph gene expression risk affective disorder application tryptophan sad treatment animal models sad main conclusions review follows brain deficiency contributes mechanism underlying sad tph involved regulation kinds genetically defined affective disorders iii activation synthesis exogenous tryptophan alone combination light therapy could effective sad treatment synergic effect combined treatments several advantages compared light tryptophan therapy alone first effective treatment patients resistant light therapy secondly tryptophan treatment prolongs antidepressant effect light therapy
gastrokine gkn highly expressed gastric tissue secreted stomach expressed gastric cancer gkn belongs brichos domain family plays major role maintaining gastric mucosa integrity previously demonstrated recombinant human gkn protein able interact amyloid precursor protein app endowed antiamyloidogenic property inhibited polymerization beta peptide released app upon partial hydrolysis report gkn act physiological suppressor beta production gastric cancer cells gkn blocked access gamma secretase app thereby facilitating cleavage app alpha beta secretases gkn directly interacted app terminal fragments addition affect gamma secretase activity gastric cancer cells alter notchl processing gkn mediated inhibition app processing might represent new approach prevention therapy alzheimer disease elsevier societe francaise biochimie biologie moleculaire sfbbm rights reserved
increasing interest simultaneously optimizing many objectives typically three objectives problems leads emergence various many objective algorithms evolutionary multi objective optimization field however contrast development algorithm design assess many objective algorithms received scant concern many performance indicators designed principle number objectives practice invalid infeasible used many objective optimization paper explain difficulties popular performance indicators face propose performance comparison indicator pci assess pareto front approximations obtained many objective algorithms pci evaluates quality approximation sets aid reference set constructed points reference set divided many clusters proposed indicator estimates minimum moves solutions approximation sets weakly dominate clusters pci verified analytic comparison several wellknown indicators empirical test four groups pareto front approximations different numbers objectives problem characteristics
aims megakaryocyte expansion myeloproliferative neoplasms mpns due uncontrolled proliferation accompanied dysregulation proapoptotic antiapoptotic mechanisms investigated intrinsic extrinsic apoptotic pathways megakaryocytes human mpns define mechanisms involved methods megakaryocytic expression proapoptotic caspase caspase diablo antiapoptotic survivin proteins investigated bone marrow specimens mpns controls using immunohistochemistry megakaryocyte percentage positivity assessed light microscopy correlated mpn entity jak calr mutation status platelet count results proportion megakaryocytes mpns expressing caspase caspase diablo survivin significantly greater controls greater proportion myeloproliferative megakaryocytes expressed survivin relative reciprocal inhibitor diablo differences seen myelofibrosis polycythaemia vera essential thrombocythaemia caspase calr mutated cases greater megakaryocyte positivity compared jak mutation proapoptotic caspase expression showed positive correlation platelet count marked myelofibrosis calr mutated cases conclusions disruptions targeting intrinsic apoptotic cascade promote megakaryocyte hyperplasia thrombocytosis mpns progressive dysfunction apoptosis evidenced marked reduction proapoptotic caspase accumulation myelofibrosis dysfunction caspase necessary proplatelet formation may mechanism excess thrombocytosis associated calr mutations survivin seems key protein mediating megakaryocyte survival signature mpns potential therapeutic target
introduce mobile agents mobile crowdsensing crowdsensing campaigns designed different roles implemented mobile agents role based tasks mobile agents include collecting data analyzing data sharing data campaign mobile agents execute control campaign autonomously multi agent system migrate opportunistic network participants devices mobile agents take account available resources devices match participants privacy requirements campaign requirements sharing task results real time facilitates cooperation towards campaign goal maintaining selected global measure energy efficiency discuss current challenges crowdsensing propose mobile agent based solutions campaign execution monitoring addressing data collection participant related issues present software framework mobile agents based crowdsensing seamlessly integrated web set simulations conducted compare mobile agent based campaigns existing crowdsensing approaches implemented evaluated small scale real world mobile agent based campaign pedestrian flock detection simulation evaluation results show mobile agent based campaigns produce comparable results less energy consumption number agents relatively small enables network data processing sharing data task results insignificant overhead
purpose recent times progression technology growing demands customers substantially influenced services sector introduce fast real time mechanisms providing mark services meet requirements organizations going change end user operating systems success rate change low purpose paper address one practitioners complaint one tells uncovers indirect effects knowledge management strategies personalization codification toward organizational change via organizational learning change readiness current study also highlights organizational learning change readiness helpful reduce detrimental effects organizational change cynicism toward success change process design methodology approach temporal research design used get appropriate responses targeted population two stages pre change time post change time cumulative responses obtained banking sector pakistan findings results current study promising stated strategies indirect effect successful organizational change organizational learning change readiness moreover change cynicism weakening effect change process managed effective learning orientation employees developing readiness change organizations research limitations implications change agents use optimal mix personalization codification strategies develop learning environment readiness change organizations beneficial implementing change successfully moreover change readiness organizational learning context change equally beneficial reduce organizational change cynicism well originality value study introducing unique model initiate change help strategies organizational learning readiness change
purpose aim research evaluate reliability aboriginal children health well measure achwm methods two cohorts children wiikwemkoong unceded territory recruited study child completed achwm independently computer tablet running customized survey app data first second cohorts used estimate internal consistencies using cronbach alpha subgroup second cohort completed survey twice within day data subgroup used evaluate test retest reliability using random effects intra class correlation coefficient icc results participants first cohort participants second cohort repeated measures subgroup comprised participants second cohort internal consistency statistic cronbach alpha first second cohorts test retest reliability icc achwm summary scores based repeated measures subgroup conclusions results establish internal consistency test retest validity achwm important finding enable aboriginal communities use measure confidence promote voices children reporting health achwm essential data gathering tool enables evidence based health care aboriginal communities
background evidence quantitative studies suggest tai chi produces variety health related benefits qualitative studies investigated older adults perceive benefit tai chi objective current study qualitatively evaluate perceived benefits tai chi practice among community older population methods study conducted participants trial examining effects week tai chi training ischemic stroke risk community older adults total participants randomly selected convenience sample participants completed week tai chi training interviewed regarding perceived benefit physical mental health whether tai chi exercise suitable elderly results participants agreed tai chi training could relax body make comfortable thought tai chi training could promote physical health including relieving pain enhancing digestion strengthening immunity enhancing energy improving sleep quality enhancing mental emotional state improving mood reducing anxiety improving concentration promoting interpersonal relationship participants also agreed tai chi exercise appropriate community older people three primary themes emerged content analysis improving physical health enhancing mental emotional state conforming request elderly conclusion findings indicate regular tai chi exercise may positive benefits terms improved physical health mental state among community elderly population may useful feasible body mind exercise community elderly population positive effects advantages
background transition adulthood gradual change roles responsibilities identified challenging time adolescents young adults physical disabilities including cerebral palsy health care education employment independent living community engagement identified areas concern however relatively little research done understand experiences perceptions needs individuals cerebral palsy transition toward adulthood objective objective study explore transition experiences perceptions needs young adults cerebral palsy living one state southeastern united states methods focus groups nine young adults cerebral palsy years conducted focus group interview explored preparation transition experiences navigating adulthood audio recorded groups transcribed analyzed using thematic analysis results young adults cerebral palsy identified numerous challenges associated navigating adulthood main themes thrust adulthood navigating systems services understanding managing body dealing stereotypes prejudice conclusions findings highlight need holistic approach transition focus building capacity empowerment navigate complex systems care navigators facilitators needed additionally practitioners service providers adult systems need education cerebral palsy elsevier inc rights reserved
present study concerned impression formation context information others limited time private nature examined accuracy judges ratings target individuals basic personality traits affective traits assertive self presentation tactics based natural stream thought latter furthermore explored moderating role self presentation accurate evaluations others group participants recorded natural stream thought served basis judges ratings participants also completed self report measures basic personality traits affective traits assertive self presentation tactics results partially confirmed possible judges form accurate impression target individuals personalities context judges possess small amount relatively private information target individuals even possible judges detect target individuals self presentation tactics particularly self promotion addition individuals use self promotion exemplification private context often viewed differently less often
paper deals estimation neuronal activation unmeasured physiological information using blood oxygenation level dependent bold signal measured using functional magnetic resonance imaging fmri propose use observer based approach applied balloon hemodynamic model latter describes relation neural activity bold signal balloon model expressed nonlinear state space representation states parameters input neuronal activation unknown study focuses estimation hidden states neuronal activation model first linearized around equilibrium observer applied linearized version numerical results performed synthetic data presented
objective inflammatory bowel disease ibd entails high economic burden society aimed estimate current future impact introduction biosimilars infliximab ibd related health care costs methods designed stochastic economic model simulate introduction biosimilars ibd using year time horizon based dutch situation prevalence data ulcerative colitis crohn disease ibd related health care costs data used input assumptions made price reductions anti tumour necrosis factor tnf therapy increase anti tnf prescription rate development hospitalization costs base case scenario included gradual decrease prices biosimilars gradual decrease prices original anti tnf compounds annual increase anti tnf prescription rate compared introduction biosimilars sensitivity analyses performed results base case cost savings total years average sic per patient sic per patient yielding sic million total cost savings reduction netherlands results predominantly determined price reduction anti tnf therapy threshold price reduction physicians switch patients towards biosimilars extent switching take place conclusions introduction biosimilars infliximab expected major impact cost profile ibd economic impact depend local pricing procurement policies physician willingness switch patients biosimilars
osteoporosis hypertension two widespread diseases share many risk factors advanced age early menopause smoking physical inactivity aim study examine association fragility fractures anti hypertensive drugs subgroup according anatomical therapeutic chemical classification system atc diuretics subgroup blocker subgroup calcium antagonist subgroup renin angiotensin aldosterone system regulator subc drugs administration osteoporosis among osteoporotic population region southern italy retrospectively studied hospital discharge data hdd apulian database period find fragility fractures treated hospitalization men aged years women aged years checked database drug prescriptions identify patients taken least one osteoporosis drug within latter group based hospital admissions prescription records identified patients affected hypertension observed apulia patients hospitalized diagnosed fragility fractures prevalence hypertension patients apulia period estimated region period prevalence patients fragility fracture also hypertension percentage fracture lowest female population aged years highest women aged years observed hypertensive patients frequent site fracture femur cases least frequent tarsus metatarsus cases combined patients took angiotensin converting enzyme ace inhibitor diuretic drugs presented higher number fragility fractures calcium antagonists beta blockers atc anti hypertensive drugs linked reduced incidence lesions hypertension associated increased fracture risk apulia population bone demineralization effect disease taken account management patients different distribution fragility fractures relation anti hypertensive treatment warrants investigation
understanding members research team cooperate identifying possible synergies may crucial organizational success using data driven approaches recommender systems may able find promising collaborations publication data yet outcome scientific endeavors publications produced sparingly comparison forms data online purchases order facilitate data augmenting research cooperation suggest combine data driven approaches text mining topic modeling machine learning interactive system components interactive visual recommendation system system leads augmented perspective research cooperation network interactive visualization analyzes cooperation could intensified due topical overlap allows reap benefit worlds first utilizing computational power analyze large bodies text second utilizing creative capacity users identify suitable collaborations machine learning algorithms may fall short
universal high frequency three phase electricmotor model used design process electric motor drive systems proposed model combined models filter cable inverter form complete drive system allows common differential mode high frequency analysis studying bearing currents electromagnetic interference overvoltages motor windings caused high frequency reflections model phase symmetrical meaning beginning end phase equal central part inserted enables modeling delta star winding connections three phases equations used calculate model parameters presented based common differential mode impedance measurements model simplified considering electric discharge machining bearing currents affected common mode states simplified model used delta winding connection also presented model calculated common differential mode impedances compared impedances measured outer rotor brushless direct current motor paper ends providing obtained simulation measurement results common differential mode currents bearing voltages studied three phase delta winding connected electric motor
systems thinking holistic approach puts study wholes parts study explores systems thinking among school middle leaders teachers management responsibility team teachers aspect school work interviews held school coordinators among year heads heads departments evaluation coordinators instruction coordinators information communications technology coordinators data analysis revealed systems thinking among school middle leaders consists four characteristics seeing wholes using multidimensional view influencing indirectly assessing significance findings study expand existing knowledge systems thinking school leadership discussing practical implications well research avenues
background objectives developmental coordination disorder dcd prevalent childhood movement disorder impacting ability perform movement skills age appropriate level although differences grey matter volumes found related developmental disorders evidence linked dcd date cross sectional study assessed structural brain differences children without dcd methods high resolution structural images acquired children aged years including children dcd percentile mabc structural voxel based morphology analysis performed determine group differences focal volumes results children dcd found significant large right lateralised reductions grey matter volume medial middle frontal superior frontal gyri compared controls addition motor proficiency covariate explained group volume differences suggesting volumes motor regions reflective level motor proficiency positive correlation motor proficiency relative volume also identified left posterior cingulate precuneus conclusions volume reductions premotor frontal regions may underlie motor difficulties characteristic dcd possible intervention approaches targeting motor planning attention executive functioning processes associated regions reduced volume may result functional improvements children dcd isdn published elsevier ltd rights reserved
water pollution major environmental problem united states improve surface water quality coulee baton watershed louisiana collaborative nonpoint source pollution control study initiated conservation measures best management practices bmps including cross fencing pasturelands irrigation land leveling grade stabilization structures two irrigation water pipeline livestock well covering total agricultural land repair replacement septic systems watershed voluntarily implemented landowners homeowners water samples collected seven monitoring sites rain events september august laboratory determinations water samples included total suspended solids tss total dissolved solids tds total solids five day biological oxygen demand bod nitrate nitrite nitrogen soluble reactive phosphate srp total phosphorus total kjeldahl tkn chloride fluoride sulfate fecal coliform counts surface water temperature dissolved oxygen turbidity conductivity determined field using ysi sonde ysi incorporated yellow springs ohio watershed bod concentrations fecal coliform count ranged respectively ppm probable number mpn per months march april june september showed average higher concentrations tds fecal coliform count srp respectively compared ongoing bmps post bmps tss srp bod concentrations average lower respectively developed land use types failed septic systems identified major sources fecal coliform pollution results suggest comprehensive strategies necessary effective nonpoint source pollution control agricultural watersheds
paper presents integrated model risk management electricity traders integrates unit commitment problem provides power generation units dispatch electricity price forecasting power system artificial neural network ann models provide electricity price forecasting neighbouring power system incorporating clustering algorithm integrated model extended estimate traders profitability risk incorporating risk provisions integrated model applied directional trading italian greek day ahead electricity markets neural network models provide forecasts wholesale electricity price greece italy respectively model attributes confidence level price forecasts depending data clustering forecasting performance model integrated model identifies periods high price margins trading power flow aligned forecasting confidence risk level integrated model provide price signals profitability traders useful insights risk traders elsevier ltd rights reserved
present palirria self adapting work stealing scheduling method nested fork join parallelism used estimate number utilizable workers self adapt accordingly estimation mechanism optimized accuracy minimizing requested resources without degrading performance implemented palirria linux barrelfish operating systems evaluated two platforms core non uniform memory access numa multiprocessor simulated core system compared state art observed higher accuracy estimating resource requirements leads improved resource utilization performance par better executing fixed resource allotments copyright john wiley sons ltd
although quality preschool supports young children health safety quality defined diversely enough delivery varied among kindergarten teachers current study first examine compare perceptions school safety urban rural kindergarten teachers sixty seven hong kong teachers urban region china yunnan teachers rural region china rated perceived knowledge attitudes regarding child safety perceived school safety young children results showed although yunnan teachers rated schools safety less favourably hong kong teachers rated better knowledge stronger attitudes child safety hong kong teachers age total teaching experience yunnan teachers perceived knowledge significantly predicted perceived school safety young children implications quality multi level construct relation quality teacher education discussed
traditional tools found occupational risk assessments preliminary hazard analysis checklists based isolation particular activity entire process created application specific environments manufacture strategy makes results evaluations distant real situations construction complex endeavor involve multiple contractors groups working contractor work occurs constant change varying demands context workers move daily journey health safety often threatened activities carried contractors groups study utilizes functional resonance analysis method fram aims describe function couplings may combined way variability performance rather failure poor functioning creates occupational risk study also contributes evolution fram proposing application analytic hierarchy process investigate relative importance criteria alternatives identification phenotypes performance variability well aggregation variability
light initiated generation energetic carriers attracted considerable attention paradigm photocatalysis solar energy conversion use noble metal nanoparticles support localized surface plasmon resonances widely explored medium realizing paradigm recently shown composite nanostructures enabling interplay dielectric scattering resonances broadband absorption small metal nanostructures phenomenon termed scattering mediated absorption used mediate energetic carrier transfer selective photochemistry low intensity light completely circumventing plasmon resonance work develop multiscale modeling approach elucidating hot carrier dynamics initiated scattering mediated absorption calculations reveal unique hot carrier distributions dynamics arise scattering mediated absorption compared plasmon excitation also suggest variety circumstances scattering mediated absorption may lead efficient hot carrier generation compared plasmon resonance external illumination conditions results important first step understanding phenomena scattering mediated hot carrier generation potential expanding palette materials utilized hot carrier mediated photochemistry beyond plasmonic metals enabling unique pathways photocatalytic transformations graphics
fruits reduced harvesting period high degree perishability results short shelf life therefore order extend shelf life foodstuffs maintaining low level microbial spoilage deterioration reactions occur fresh fruits treated obtaining semi finished products products commonly used starting materials food industries like jams gelatines marmalades ones due extension productions throughout whole year among possible techniques southern italy industry study uses three different techniques produce package preserve semi finished fruits one based individually quick freezing one low pressure superheated steam drying far infrared radiation one ohmic aseptic treatment last years food industries focused attention towards high quality products also towards environmental friendly productions therefore aim work use life cycle assessment lca approach compare environmental emissions three different production preservation techniques used industry study environmental impacts evaluated using detailed lca analysis normalizing consumptions emissions functional unit one apricots dry basis data analysed using simapro software whereas ecoinvent database information collected chosen industrial site used life cycle inventory according reference standard lca iso elsevier ltd rights reserved
succession events revegetation rarely studied plant consortium good initial development may come inadequate later resulting exposed soil susceptible weathering forces objective study monitor characteristics associated vegetative stabilization long term appearance new cover forms soil exposure response planting grasses legumes steep road slope alongside highway four years recovery new forms soil cover exposure observed experimental plots called typologies described brachiaria grass cover legume plants gordura grass invasive species geotextile decomposing residues microphytic crusts soil crust exposed soil erosion rock outcrops characteristics typologies quantified two surveys rainy season addition different typologies experimental plot mapped maps used analyze dynamics spatial distribution frequency competition among typologies identified two surveys total typologies vegetation species microphytic crusts relevant revegetation microphytic crusts important initial stage ecological succession resulting rapid stabilization reclamation degraded surfaces favoring appearance invasive species seasonal variation two surveys showed erosion soil exposure decreased increase vegetation cover microphytic crust development
cricket system typical multivariable uncertainty strong coupling nonlinear dynamics underactuated system two dimensional extension club system many scholars home abroad study nonlinear control system experimental platform usually fuzzy adaptive control method applied uncertain nonlinear systems practical engineering common multivariable nonlinear system control matrix irreversible lacked certain applicability process cricket uncertain nonlinear system control gain matrix determinant equal zero namely control matrix irreversible ball control therefore design supervise system stability supervision state variable changes hierarchical controller great significance paper controller divided two layers upper layer supervision optimization lower combined adaptive rule sliding mode theory advantages intelligent algorithm design controller
order reduce time complexity situation element acquisition cope low detection accuracy small class samples caused imbalanced class distribution attack samples wireless sensor networks situation element extraction mechanism based deep auto encoder network proposed mechanism deep auto encoder network introduced basic classifier identify data type hierarchical training auto encoder training method based cross entropy loss function back propagation algorithm proposed overcome problem weights updating slow traditional variance cost function momentum factors added improve convergence performance meanwhile stage fine tuning classification deep network active online sampling algorithm proposed select sample online updating network weights eliminate redundancy total samples balance amounts sample types improve classification accuracy small sample simulation analysis instance data scheme good accuracy situation factors extraction
configuration options widely used customizing behavior initial settings software applications server processes operating systems distinctive property option processed defined described different parts software project namely code configuration file documentation creates challenge maintaining project consistency evolves also promotes inconsistencies leading misconfiguration issues production scenarios propose approach detection inconsistencies source code documentation based static analysis approach automatically identifies source code locations options read location retrieves name option inconsistencies detected comparing results option names listed documentation evaluated approach multiple components apache hadoop complex framework options tool orplocator able successfully locate least one read point documented options within four hadoop components comparison previous state art technique shows tool produces accurate results moreover evaluation uncovered previously unknown real world inconsistencies documented options source code
great attention paid nitrogen oxides particulate matter emitted compression ignition engines adoption methane dual fuelled diesel could contribute reduction pollutants paper aims investigate combustion phenomena occurring premixed methane air charge ignited direct injection diesel fuel research activity performed production compression ignition engine three cylinder equipped common rail injection system order operate diesel methane dual fuel mode intake manifold engine modified set electronic port fuel injector suitable gaseous fuels different engine speeds loads tested engine condition small part total energy provided direct injected diesel fuel remaining methane thermodynamics analysis combustion process performed conventional measurement involving cylinder pressure acquisition endoscope based optical techniques carried combustion visualization high spatial distribution temporal evolution two colour pyrometry method applied flame images evaluate temperature soot concentration method allows achieve better insight pollutant formation experimental results revealed combustion occurs lower temperature soot formation diesel operation thus leading lower nitrogen oxides particle emissions exhaust elsevier rights reserved
paper automated twistlock handling robot system proposed aim perform tedious danger works safe efficient operations proposed robot system composed unmanned ground vehicle human friendly lightweight robot manipulator robot gripper three fingers kinect sensor object recognition segmentation algorithm developed models elaborated different twistlocks library built automatic object recognition registration purposes architecture design software module introduced full cycle twistlock handling operation illustrated simulations reported order evaluate feasibility operation performances system
century condom united states cheap useful largely unmentionable product federal state statutes prohibited advertising open display condoms distribution mail across state lines sale purpose birth control states even owning using condoms illegal end world war condoms increasingly acceptable prevention sexually transmitted disease unique dual function disease prevention contraception created ongoing ambiguities sellers consumers distributors well legal political health moral leaders condoms emerge shadows join personal hygiene products open drugstore supermarket shelves national advertisements came aids despite rise ronald reagan radical right demonization condoms initial reluctance condom merchants market gay constituencies hiv aids epidemic slowly inexorably propelled condom top prevention agenda condom journey lewd device global superstar fitful colorful comstock act prohibiting birth control information devices created vast underground operation periodically illuminated however arrests protests legal proceedings media coverage essay chronicles one moment illumination legal battle legitimacy legality trojan brand condom trademark unusual series advertisements produced youngs rubber corporation makers trojans dramatize ethical economic issues trademark battle culminating youngs rubber corporation lee inc court appeals second circuit landmark case trademark law established right trojan brand condom despite ambiguous dual function protection federal trademark seek show youngs antipiracy series illuminates paradox visibility illuminating paradox binary division establish one depends inevitably invoking making visible even suppress essay case study negotiation dialectic
effect weight loss long term mild calorie diets mcd plasma metabolites unknown study examine whether mcd induced weight reduction caused changes extended plasma metabolites overweight obese subjects aged years consumed mcd approximately kcal day deficit weight maintenance diet control randomized controlled design three year clinical intervention period plasma samples analyzed using uplc ltq orbitrap mass spectrometry three year mcd intervention resulted weight loss significant decreases homa three year follow mcd group showed reductions following metabolites leucine phenylalanine lysopcs three year mcd group follow identified increases palmitic amide oleamide considering age related alterations identified metabolites mcd group showed greater decrease leucine phenylalanine compared control group overall change delta bmi positively correlated delta delta homa delta leucine delta delta homa positively correlated delta delta leucine delta phenylalanine delta weight loss resulting three year mild caloric restriction lessens age related increase reduces leucine phenylalanine overweight obese subjects changes coupled improved insulin resistance clinicaltrials gov nct
aims aim study develop models aid decision prolong dual antiplatelet therapy dapt requires balancing individual patient potential benefits harms methods results using population based electronic health records ehrs caliber england patients evaluated year acute myocardial infarction developed patients validated prognostic models cardiovascular cardiovascular death stroke events three different bleeding endpoints applied trial effect estimates determine potential benefits harms dapt net clinical benefit individuals prognostic models cardiovascular events index bleeding index well calibrated year risk cardiovascular events overall lowest highest risk individuals major bleeding lowest highest risk patients every patients treated per year estimated cardiovascular events prevented major bleeding events caused highest risk patients cardiovascular events prevented major bleeding events caused lowest risk patients net clinical benefit prolonged dapt patients depending benefits harms weighted conclusion prognostic models cardiovascular events bleeding using population based ehrs may help personalise decisions prolonged dapt year following acute
traditional design testability dft arduous time consuming iterative process testability assessment design modification improve dft efficiency dft process based test point allocation proposed process set optimal test points automatically allocated according signal reachability constraints testability criteria thus iterative dft process completed computer test engineers released concentrate system design rather repetitive modification process perform test point allocation dependency matrix signal potential test point matrix defined based multi signal flow graph genetic algorithm adopted search optimal test point allocation solution based matrix last experiment carried evaluate effectiveness algorithm
paper contributes growing literature economics green buildings merging auction theory hedonic regression analysis investigate relationship market concentration price premiums american market eco certified real estate assets auction theory used model price formation eco investors may differ valuation assets controlling large number features empirical results provide evidence significant positive relationship investors eco certified market share prices eco certified space contributing recent debate nature green premium find eco investors creating clientele effects may subject green winner curse
objectives assess desensitization parents repeated exposure violence sex movies methods national sample parents living least target child age groups years old viewed random sequence pairs short scenes either violent sexual content popular movies unrestricted youth audiences rated unrated restricted age years without adult supervision rated parents indicated minimum age would consider appropriate view film predictors included order presentation parent child characteristics parent movie viewing history results exposure successive clips progressed parents supported younger ages appropriate exposure starting age years confidence interval violence age years sex declining age years violence years sex parents also reported increasing willingness allow target child view movies exposures progressed desensitization observed across parent child characteristics violence toward human non human victims movie rating frequently watched movies readily desensitized violence conclusions parents become desensitized violence sex movies may contribute increasing acceptance types content parents raters employed film industry
paper conduct research modern virtual interactive products dynamic presentation mode based computer graphics scene modeling based image modeling based core issue image geometric modeling studies recover image object scene geometry information build geometric model said rendering editing interactive virtual reality technology new comprehensive technology system user necessary equipment natural way interaction core objects virtual environment research integrates state art techniques propose novel virtual interactive products showing platform meaningful
background reproductive lifestyle factors influence breast cancer risk prognosis might breast cancer subtype subtypes defined immunohistochemical hormone receptor markers gene expression signatures used predict prognosis breast cancer patients based tumour biology investigated association established breast cancer risk factors gene prognostication signature breast cancer patients patients methods standardised questionnaires used obtain information established risk factors breast cancer dutch patients mindact trial clinical pathological genomic information obtained trial database logistic regression analyses used estimate associations lifestyle risk factors tumour prognostic subtypes measured gene mammaprint signature low risk high risk tumours results breast cancer patients included low risk high risk tumours current body mass index bmi age menarche age first birth age menopause hormonal contraceptive use hormone replacement therapy use associated manunaprint parous women higher parity associated lower risk confidence interval longer breastfeeding duration higher risk developing high risk tumours risk estimates similar within oestrogen receptor positive disease stratifying menopausal status associations remained present post menopausal women conclusion using prognostic gene expression profiles indications specific reproductive factors may associated prognostic tumour subtypes beyond hormone receptor status elsevier ltd rights reserved
order improve azithromycin antibacterial activity acidic medium monomethoxy poly ethylene glycol block poly aspartic acid graft imidazole copolymer synthesized allylation free radical addition ring opening polymerization amidation reactions methoxy poly ethylene glycol raw material drug loading capacity encapsulation efficiency azithromycin loaded micelles prepared via thin film hydration method respectively drug loaded micelles showed dependent property respects particle size zeta potential range could control drug vitro release demonstrate higher release rate vitro antibacterial experiment indicated activity azithromycin loaded micelles aureus superior free azithromycin medium using fluorescein substitute dependent fluorescence decrease property laser confocal fluorescence microscopy analysis confirmed cellular uptake micelles improved due protonation copolymer imidazole groups enhanced cellular uptake release drug caused activity enhancement acidic medium compared free drug micellar drug delivery system potential application field bacterial infection treatment elsevier inc rights reserved
research linear electrical generator wave energy farm utilizing resonance power buoy system studied mechanical resonance characteristics buoy wave analyzed maximize kinetic energy relatively small wave energy area wrps operated research chose analog model linear electrical generator size one hundredth actual size wprs wave energy farm utilizing resonance power buoy system prior verifying characteristics actual model linear electrical generator wrps addition finite element analysis conducted using commercial electromagnetic analysis software named maxwell examine electric characteristic linear generator finally verification dynamic electric characteristics linear generator prototype manufactured experiments measure displacement output electric power performed
binding doxorubicin dox cross linked pluronic paa egdma paa egdma microgels different alpha alpha salt concentrations investigated using isothermal titration calorimetric itc optical scanning electron microscopic techniques sem seek elucidate mechanisms interaction release dox cross linked microgels composed pluronic poly acrylic acid itc results indicated high binding affinity dox microgel function salt concentrations due impact electrostatic shielding dox binding process applying polyelectrolyte theory allows decoupling gibbs free energy binding describes role non electrostatic interaction dox microgel presence dox within microgel resulted collapse microgel due charge shielding interactions self association polymer bound dox molecules diffusion dox microgel controlled dissociation coo dox coupling pairs elsevier rights reserved
paper aims provide road map future works related reverse engineering field expertise reverse engineering mechanical context relates process working bottom fashion namely goes lower level concept product closer final product higher level one closer ideation step nowadays manufacturing industry facing unprecedented increase data exchange data warehousing comes new issues work explore store data efficient manner stored nonetheless trend also creates new opportunities manage integrate data expertise workflows paper cover possibilities offered machine learning succeed challenge also present first major step road map order achieve research goals plan design metric quantify well precise perform specific reverse engineering tasks detection segmentation classification mechanical parts imagery data aspire open metric make freely widely available researchers industry order compare effectiveness robustness preciseness existing future approaches
herein present case anaphylaxis multiple family members ingesting silkworms asian delicacy food allergies including anaphylaxis unfortunately common previous reports multiple family members suffering anaphylactic reaction eating silkworms addition family members required multiple doses epinephrine eventually epinephrine infusion improve blood pressures interventions including epinephrine infusions started emergency medical services ems line medical direction reaction required treatment extensively documented medical literature
rainbow trout farming automatic measuring classification open problem small farms work done manually within laborious process achieving inaccurate measurements research present state art results rainbow trout oncorhynchus mykiss length estimation within water flow using image processing purpose designed implemented evaluated novel measuring prototype allows fish swim throughout channel order measured classified taking advantage rainbow trout instinctive behaviour swimming water flow prototype provided vision component able detect measure rainbow trout online capturing processing downward view images fish passes camera fish detected system crosses control point event recalls measuring process measure approximate third order regression curve fish body estimate length experimental evaluation achieving mean absolute error mae estimating rainbow trout lengths encouraging result allows draw different venues future work based experimental findings elsevier rights reserved
fluorescence situ hybridisation fish molecular cytogenetic technique regularly applied formalin fixed paraffin embedded ffpe tissue sections variety cancers assess chromosomal aberrations however high quality fish requires optimal enzymatic digestion insufficient digestion noted hybridisation signals evaluated fluorescence microscope consequence fish results may unreliable experiment might repeated solve problem developed new method real time evaluation enzymatic tissue digestion termination enzyme activity proper time facilitates successful hybridisation experiments repeated first performed fish ffpe samples pepsin digested different times revealed distinct morphological changes within nucleus perinuclear space detectable light microscopy observations suggested presence intact clear bare nuclei surrounded translucent perinuclear space might serve indicator adequate digestion developed protocol assessment indicator based morphological features applied collection tissue samples partly breast cancer partly different types lymphoma prior fish fish success rate significantly higher conventional method successful cases morphological signs adequate digestion paralleled easily interpretable fish signals new method real time assessment digestion quality improved success rate fish addition simple rapid
high efficiency method proposed suppress magnetic core imbalance phase shifted full bridge psfb converters compared conventional solutions controlling peak current mode pcm adding blocking capacitance proposed method several advantages lower power loss smaller size additional current sensor blocking capacitor removed time domain model secondary side built analyze relationship transformer core imbalance cathode voltage secondary side rectifiers approximate control algorithm designed achieve asymmetric phase control reduces effects imbalance prototype built verify proposed method experimental results show numerical difference primary side peak currents two adjacent cycles suppressed approximately meanwhile compared pcm solution efficiency psfb converter slightly improved
point care tools needed sub saharan africa ssa improve pediatric burkitt lymphoma diagnosis treatment evaluated plasma epstein barr virus pebv dna pediatric biomarker malawi prospectively enrolled children compared classical hodgkin lymphoma chl nonlymphoma diagnoses pediatric patients received standardized chemotherapy supportive care pebv dna measured baseline mid treatment treatment completion assessed children pebv dna detected chl nonlymphoma proportions higher versus nonlymphoma similar versus chl detected median pebv dna log copies log copies chl log copies nonlymphoma higher levels versus chl trend toward higher levels versus nonlymphoma pebv dna declined treatment cohort overall increased several children clinical relapse twelve month overall survival cohort overall children baseline pebv detected survival worse baseline pebv dna log copies versus log copies also pebv dna persistently detectable mid treatment versus undetectable among children baseline pebv dna detected viremia significant risk factor death months multivariate analyses adjusted hazard ratio per log copies quantitative pebv dna potential utility diagnosis prognosis response assessment pediatric ssa new burkitt lymphoma frequent childhood cancer sub saharan africa although highly curable resource rich settings outcomes much worse region point care tools needed improve diagnosis treatment epstein barr virus ebv causally associated common endemic form disease first study systematically assess plasma ebv dna pediatric diagnosis prognosis response assessment sub saharan africa results show plasma ebv dna may implementable biomarker facilitate diagnosis risk stratified response guided therapy challenging population region
recent decades compressive sensing popular theory studying inverse problem widely used synthetic aperture radar sar image processing however computation complexity based methods limits wide applications sar imaging paper propose novel sparse sar imaging method using multiple measurement vectors model reduce computation cost enhance imaging result based using structure information matched filter processing new sar imaging method applied high quality high resolution imaging sub nyquist rate sampling advantages saving computational cost substantially time memory results simulations real sar data experiments suggest proposed method realize sar imaging effectively efficiently
study objectives examine association race ethnicity sleep curtailment infancy mid childhood determine extent socioeconomic contextual factors explain racial ethnic differences independently associated sleep curtailment methods studied children longitudinally project viva pre birth cohort study months years age main exposure child race ethnicity main outcome sleep curtailment score months years score ranged indicated maximal sleep curtailment indicated never curtailed sleep results mean standard deviation sleep curtailment score points adjusted models beta black points hispanic points asian points children lower sleep scores white children adjustment sociodemographic covariates attenuated racial ethnic differences sleep scores black hispanic children strengthened differences asian children adjustment environmental behavioral variables substantially change differences independently low maternal education living households incomes viewing child bedroom associated lower sleep scores conclusions chronic sleep curtailment infancy mid childhood prevalent among black hispanic asian children differences partially entirely explained socio contextual variables independently children lower socioeconomic status greater exposures also greater sleep curtailment
purpose veterans post traumatic stress disorder ptsd high lifetime rates smoking often substantial difficulty quitting however relatively little research focussed use veterans health administration vha intensive tobacco cessation counseling services veterans ptsd characteristics veterans ptsd use services paper aims discuss issues design methodology approach present study analysis national vha administrative data fiscal year identified utilization rates vha intensive tobacco cessation counseling among veterans diagnoses ptsd tobacco use disorder tud correlates tobacco cessation counseling use findings altogether veterans ptsd diagnosed tud used vha tobacco cessation services percent veterans ptsd used tobacco cessation counseling services likely homeless comorbid drug use disorder used vha services frequently counterparts access tobacco cessation counseling use outpatient mental health substance use services strongest correlate tobacco cessation counseling use veterans sample notably veterans ptsd tud hiv likely engage tobacco cessation services originality value study demonstrates future efforts focus increasing provider veteran awareness accessibility vha intensive tobacco cessation counseling veterans ptsd
use cloud database service daas gradually increasing private government organizations organizations considering outsourcing local databases cloud database servers minimize operational maintenance expenses time users apprehensive confidentiality breach vital data cloud database achieve complete confidentiality data outsourced databases required keep data alwaysencrypted form entire life cycle rest transition operation premises cloud database services searchable encryption scheme allows users perform encrypted keyword search encrypted data stored database server directly without decrypting many applications requires access database multiple users data written different users using different encryption keys paper propose schemes multi user multi key encryption search cloud relational databases mes supports search operation data encrypted different keys multiple users using trusted proxy data may stored shared table one column database server best knowledge proposed schemes mes practical first time proposed databases
recent large scale remote sensing studies shown glacier mass loss south eastern tibet specifically eastern nyainqentanglha range exceeds average high asia however detailed studies individual glaciers scarce drivers behind observed changes poorly constrained date employing feature tracking techniques terrasar data periods found measurable surface velocities glacier terminus positions five debris covered glacier tongues contrary debris covered glaciers parts high asia stagnant glacier tongues common feature tracking results period suggest average deceleration compared published landsat velocities period estimated surface elevation changes five glaciers recently released one arc second resolution elevation data obtained shuttle radar topography mission interferometrical derived tandem elevation model year average rate confirm strong surface lowering region despite widely discussed insulation effect debris cover beside influence thermokarst processes delayed response times debris covered glaciers highlight abundant monsoonal summer rainfall might contribute significantly pronounced negative mass balances study region elsevier rights reserved
mobile old friendly low cost intelligent aal platform designed meet needs elderly users purpose assist old people daily activities maintaining physical cognitive fitness maintaining connection close ones increasing safety autonomy self confidence mobility paper considers main scenarios emphasized interviews conducted elders caregivers med medicine designed monitoring vital parameters assessing situation person forgets take medicine order improve condition rem reminder scenarios focused problems related cognitive ageing vsm vital sign monitoring activity analysis monitoring vital parameters using medical expertise observed behaviors pat physical activity trainer consists recommendations performing additional exercise detects low level physical activity solution elder centered taking account individual particularities illness level acceptance usability
investigate solitons optical waveguides bose einstein condensates becs governed dimensional gross pitaevskii system describes propagation electromagnetic waves optical waveguides ground state wave functions becs use symbolic computation hirota method derive analytic bright one two soliton solutions certain conditions soliton amplitude width amplification influence time modulated dispersion bright soliton shape studied via graphic analysis analysis bright solitons optical waveguides becs find amplitude width bright solitons become larger propagation certain choices time modulated dispersion shape bright soliton also affected time modulated dispersion time modulated dispersion different obtain bright parabolic like periodic type solitons
nature nonlinear molecular deformations homeotropically aligned nematic liquid crystal nlc presented start basic dynamical equation director axis nlc elastic deformations adopt space curve mapping procedure analyze dynamics nlc governed integro differential perturbed nonlocal nonlinear schrodinger equation solve using jacobi elliptic function method aided symbolic computation construct exact solitary wave solution order better understand effect nonlocality director reorientations nematic liquid crystal constructed component forms director axis using darboux vector transformation intriguing property result relation coherence breather like solitary deformation nonlocality reveals strong need deeper understanding theory self localization nlc systems elsevier rights reserved
stereotypes accurate inaccurate summarize evidence stereotype accuracy one largest replicable findings social psychology address controversies literature including long standing continuing unjustified emphasis stereotype inaccuracy define assess stereotype accuracy whether stereotypic individuating information used rationally person perception conclude suggestions building theory future directions stereotype accuracy research
objectiveproeating disorder pro communities online encourage harmful weight loss weight control practices study examined association exposure pro content online subjective well swb among adolescents young adults four countries methodcross national data collected germany finland internet users aged years male questionnaire assessed swb exposure harm advocating websites online activity prior victimization social belonging ordinary least squares ols regression models assessed relationship swb pro exposure adjusted number confounding factors resultsof participants exposed pro content germany finland exposure pro content online negatively associated swb germany finland also adjusting confounding factors offline social belonging moderated association pro swb discussionparticipants visited pro websites reported lower swb others potentially harmful impact visiting sites buffered strong offline social belonging given observed similarities across countries important families health professionals educators stay abreast online communities possible contra recovery influences able discuss internet contents way increases treatment motivation wiley periodicals inc int eat disord
article aims add relatively small body literature online hatred particular focuses role social networking sites may play development polarisation exploring online users respond explicit online hate materials specifically article discusses ways self selected sample youtube users responded via posting online comments video clip white female train passenger called emma could seen racially abuse passengers thematic analysis youtube comments identified four main themes making sense emma encapsulated posters attempts find explanations emma behaviour meeting hatred hatred described posters attempts oppose emma racism means resorting aggressive hateful language versus encapsulated posters tendencies categorise posters outgroups based particular stance racism contesting britishness expressed posters attempts articulate contest means british whilst current analysis provides evidence hateful web content fuel aggressive hateful responses many comments analysed emphasised common group membership alongside people right claim membership particular social category britishness current evidence therefore suggests least specific context study hateful web content may necessarily lead automatic endorsement escalation hatred
sexual dysfunction common side effect antipsychotic medications may partly caused dopamine antagonism elevation prolactin qualify randomized study aripiprazole monthly aom dopamine receptor partial agonist showed noninferiority subsequent superiority versus paliperidone palmitate dopamine receptor antagonist heinrichs carpenter quality life scale qls patients schizophrenia aged years sexual dysfunction arizona sexual experience scale serum prolactin levels also assessed odds sexual dysfunction lower aom versus week adjusted odds ratio confidence interval men women patients aged years among patients shifting sexual dysfunction baseline none week trend toward greater improvement qls total score mean prolactin concentrations decreased aom miu increased miu men women six treated patients experienced prolactin related adverse events addition greater improvement qls patients lower risk sexual dysfunction prolactin elevation aom versus qualify
objectivedisparities epilepsy treatment uncommon therefore examined population based estimates initial antiepileptic drugs aeds new onset epilepsy among racial ethnic minority groups older medicare beneficiaries methodswe conducted retrospective analyses medicare administrative claims random sample beneficiaries augmented minority representation new onset epilepsy cases international classification diseases ninth revision icd icd aed seizure epilepsy claim codes aeds preceding days examined aed use concordance quality indicators epilepsy treatment quiet monotherapy initial treatment day first prescription concomitant aeds prompt aed treatment first aed within days diagnosis logistic regression examined likelihood prompt treatment demographic race ethnicity gender age clinical number comorbid conditions neurology care index event occurring emergency room economic part coverage phase eligibility part low income subsidy lis zip code level poverty factors resultsover year follow new epilepsy cases one aed whites american indian alaska native levetiracetam commonly prescribed aed whites second common phenytoin asians quiet concordance whites received prompt aed therapy whites race ethnicity significantly associated aed patterns monotherapy use prompt treatment significancemonotherapy common across racial ethnic groups older adults new onset epilepsy older aeds commonly prescribed treatment frequently delayed studies reasons treatment delays warranted interventions developed tested develop paradigms lead better care
paper apply blind source separation model scope extracting information workpiece process made given manufactured workpiece may think carrier information built process made using recent inspection technologies stylus profiler able generate signals workpiece analyze signals using independent component analysis ica various formulations develop convolutive version ica overcome technical metrological problems arisen using convolutive modification ica able demix recorded signal recover technological fingerprint simulations nist benchmarks included well case study turned workpiece elsevier ltd rights reserved
interlinking knowledge sources enable information exchange basic means build enriched knowledge based systems gains importance spread internet inconsistency however arises easily systems least due heterogeneity also due independent design makes developing methods consistency management systems pressing issue important aspect many relevant cases information individual sources may amenable change order resolve inconsistency like case autonomous management sources thus aim analyzing inconsistency system means interlinking sources changes thereof concretely consider powerful framework multi context systems decentralized heterogeneous system parts interact via possibly nonmonotonic bridge rules information exchange nonmonotonicity potential cyclic dependencies pose additional challenges call suitable methods inconsistency analysis thus provide two approaches explaining inconsistency characterize inconsistency terms bridge rules different ways pointing rules need altered restoring consistency finding combinations rules cause inconsistency show duality modularity properties notions give precise complexity characterizations provide algorithms computation implemented prototype means called hex programs results provide basis inconsistency management heterogeneous knowledge systems different orthogonal works explicitly addresses knowledge interlinks order restore consistency elsevier rights reserved
introduction strong pharmaceutical development agents targeting pathway treatment psoriasis psoriatic arthritis psa lung cancer accounts cancer related deaths worldwide roughly patients newly diagnosed non small cell lung cancer nsclc present metastatic disease poor prognosis around months therefore high unmet medical need development new potent systemic treatments deadly disease emergence immunotherapies anti anti pdl candidate therapies non small cell lung cancer nsclc indicates targeting critical immuno modulatory cytokines including within axis may proven benefit treatment lung cancer areas covered review describe current evidence aberrant settings cancer particularly regard targeting axis nsclc discuss current agents pharmaceutical development could potentially target axis discuss current limitations areas concern regarding use lung cancer expert opinion current evidence suggests moving forward agents targeting pathway may novel new oncoimmunology indications treatment paradigm nsclc
decision support methodologies precision agriculture integrate different dimensions composing added complexity operational decision problems special attention given adequate knowledge extraction techniques making sense collected data processing information assessing decision makers farmers efficient sustainable management field focusing weed management integration operational aspects weed spraying open challenge modeling farmers decision problem identifying satisfactory solutions implementation automatic weed recognition procedures objective paper develop decision support methodology detecting undesired weed aerial images building image based viewpoint consisting relevant operational knowledge applying precision spraying way possible assess potential herbicide cost reductions increased precision spraying device selecting appropriate weed precision spraying technology findings study indicate potential gains marginal cost reductions herbicides decrease significantly increased precision spraying
subplate zone transient cytoarchitectonic compartment fetal telencephalic wall contains population subplate neurons main neurons fetal neocortex play key role normal development cerebral cortical structure connectivity subplate zone disappears perinatal early postnatal period numerous subplate neurons survive remain embedded superficial gyral white matter adolescent adult brain called interstitial neurons fetal adult brain subplate interstitial neurons belong two major classes cortical cells projection glutamatergic neurons local circuit gabaergic interneurons interstitial neurons remain strategically positioned cortical white matter interface various cortical afferent systems enter deep cortical layers probably serve auxiliary interneurons involved differential gating cortical input systems widely accepted prenatal lesions alter number surviving subplate neurons number interstitial neurons nature involvement cortical circuitry represent important causal factor pathogenesis least types schizophrenia subgroup patients cognitive impairment deficits frontal lobe functions abnormal functioning cortical circuitry schizophrenia becomes manifest adolescence increased demand proper functioning prefrontal cortex review describe developmental history subplate zone subplate neurons surviving interstitial neurons well presumed consequences increased number gabaergic interstitial neurons prefrontal cortex propose increased number gabaergic interstitial neurons leads increased inhibition prefrontal cortical neurons inhibitory action gabaergic interstitial neurons facilitated strategic position cortical white matter interface limbic modulatory afferent pathways enter prefrontal cortex thus enlarged population inhibitory interstitial neurons even represent minor fraction total neuron number cerebral cortex may alter differential gating limbic modulatory inputs well cortical subcortical inputs cause functional disconnectivity prefrontal limbic cortex adolescent brain conclusion fetal subplate neurons surviving postnatal interstitial neurons important modulators cortical functions normal schizophrenic cerebral cortex isdn published elsevier ltd rights reserved
nonlinear multiplicative langevin equations complete set slow variables equilibrium systems generally derived basis separation time scales form equations universal equivalent obtained green equation nonlinear friction term brownian motion turns example general results key method derivation use different discretization schemes path integral formulation corresponding langevin equation also leads consistent understanding apparently different expressions path integral previous studies
backdrop disposing energy crisis climate change development smart grid technology considered strategy decision making countries around world meanwhile china set upsurge grid smart smart grid construction full swing paper direct process smart grid construction assesses smart grid construction two aspects management standard project management level take construction smart grid province china example paper uses expert evaluation method comprehensive weighted method make empirical analysis management level makes comprehensive objective evaluation
ability exploit emerging exascale computational systems require careful review redesign core numerical algorithms implementations fully exploit multiple levels concurrency hierarchical memory structures heterogeneous processing units become available computational platforms paper presents unite conquer approach solve linear systems equations eigenvalue problems extreme scale computing indeed two ways optimize execution restarted method large scale distributed system first one optimize number floating point operations per restart cycle maximizing concurrency inside restart cycle minimizing latencies second way accelerate improve rate convergence given computational scheme unite conquer restarted approach focuses decreasing number restart cycles coupling either synchronously asynchronously several restarted methods called also methods end restart cycle method locally gathers available results collaborating methods selects best one order create restarting information consequently permits global reduction number cycles convergence unite conquer restarted methods heterogeneous fault tolerant support asynchronous communications present big potential load balancing due properties well adapted large scale multi level parallel architectures show relevant programming paradigms allow multi level parallel expression methods software engineering technology contribute significantly achieving high scalability present experiments validating approach unite conquer restarted krylov methods several parallel distributed platforms elsevier rights reserved
designed nontoxic nonhemolytic residue peptide navrwslmrpf inhibits aggregation amyloid beta beta protein also disaggregates preformed oligomers mature beta fibrils thereby reducing associated toxicity nmr experiments provide evidence ability inhibit fibril formation primarily interaction terminus region well central hydrophobic cluster beta micromolar binding affinity toward monomeric aggregated species efficient clearance toxic aggregates vitro results future development next generation peptidomimetic therapeutic agent amyloid disease may possible
objective patient physician communication essential patient centered health care physicians concerned electronic health records ehrs negatively affect communication patients study identified framework understanding communication functions influence patient outcomes conducted systematic review literature organized within framework better understand known method comprehensive search three databases cinahl medline psycinfo yielded articles analysis results results indicated ehr use improves capture sharing certain biomedical information however may interfere collection psychosocial emotional information therefore may interfere development supportive healing relationships patient access ehr messaging functions may improve communication patient empowerment engagement self management conclusion rigorous examination ehr impacts communication functions influences patient outcomes imperative achieving patient centered care focusing role communication functions patient outcomes future ehrs developed facilitate care practice implications training alone likely insufficient address disruptions communication processes processes must improved ehrs must developed capture useful data without interfering physicians patients abilities effectively communicate elsevier ireland ltd rights reserved
aim study assess relationship socially prescribed perfectionism spp aggressiveness according components physiological emotional anger motor physical verbal aggression cognitive hostility sample included children year primary school years child adolescent perfectionism scale aggression questionnaire used assess respectively spp components aggressive behaviour anger hostility physical verbal aggression mean difference analysis showed students high levels spp scored significantly higher sub scales aggression questionnaire compared peers lower levels spp moderate effect sizes obtained cases except hostility magnitude differences small logistic regression analysis revealed dimensions aggression questionnaire predicted significantly positively high scores spp ranging results showed close relationship spp manifestations aggression european journal education psychology published elsevier espana open access article license
idiopathic pulmonary fibrosis ipf progressive disease dysregulated wound healing leading unremitting scarring loss lung function predominant symptoms dyspnea exertion persistent dry cough patients ipf cough bothersome significant negative impact quality life marker disease severity progression etiology cough ipf unclear may due architectural distortion lungs increased sensitivity cough reflex airway inflammation changes mucus production clearance also may overlap ipf cough cough due common etiologies asthma gastroesophageal reflux disease upper airway cough syndrome medications approved therapies specifically treat ipf cough recently approved medications ipf evaluated cough clinical trials focused treatments ipf cough date one randomized placebo control therapeutic study ipf cough thalidomide significantly reduced ipf cough improved quality life two additional cohort studies report interferon alpha prednisolone also decrease ipf cough however medication approved treat ipf cough currently mainstay therapy ipf cough standard cough suppressants limited efficacy often intolerable side effects future studies needed determine effective therapy alleviate particularly debilitating symptom improve overall quality life patients suffering ipf elsevier ltd rights reserved
people living hiv aids grief bereavement typically refer loss life felt hiv community however changes hiv treatments allow care providers view hiv grief way considers physical social emotional loss well loss life previously pictured kubler ross model bereavement presented way conceptualize clients living hiv dealing grief bereavement addition popular bereavement counseling approaches relevant clients hiv discussed case illustration provided
several years trend learning study spread levels education benefits trend undeniable studying using learning materials students connected internet therefore able trace quickly easily additional information given text explained adequately positive impact students development independence creativity cases possible student even notice educating course method disadvantages health problems frequent sitting computer problems social skills communication etc despite method teaching certainly indispensable future certainly replace existing system partly even completely unfortunately implementation trend simple faces many obstacles levels education theoretical fields philosophy human sciences creation learning materials easier lecture notes taught form long texts written blackboard form dictation lectures redesigned electronic form supplemented simple interactive elements used test students studies technical fields machine design automotive industry metallurgy machining etc face problems course teaching must combine theoretical information practical principles industrial practices merging theory practice creates big problem developing electronic interactive study materials identical feelings students gain real example therefore department machine design university west bohemia focused problem conducted research software tools used create educational materials sought inspiration online also colleagues universities industry paper describes tools processes including advantages disadvantages used inspiration colleagues also focusing problem
pneumonia lower respiratory tract infection causes dramatic mortality worldwide present study aimed investigate pathogenesis pneumonia identify microrna mirna biomarkers candidates targeted therapy rna peripheral blood plasma participants pneumonia severe non severe controls isolated paired end sequencing performed illumina hiseq system following processing raw reads sequences aligned genome reference consortium human genome assembly reference genome using bowtie software reads per kilobase transcript per million mapped read values obtained limma software package used identify differentially expressed mirnas mirs mir targets predicted subjected enrichment analysis addition protein protein interaction ppi network predicted targets constructed analysis identified key mirs pneumonia samples including upregulated mirnas including hsa mir hsa mir downregulated mirnas including hsa let mirs kept upregulation downregulation pattern control non severe pneumonia severe pneumonia samples predicted target genes mirs subjects non severe pneumonia control subjects severe pneumonia non severe pneumonia group markedly enriched adherens junction wnt signaling pathways kalrn ras homolog family member rhoa catenin ctnnb rna polymerase subunit polrk amyloid precursor protein app determined encode crucial proteins ppi network constructed kalrn predicted target hsa mir rhoa ctnnb polrk app predicted targets hsa let results present study demonstrated hsa let may serve role development cancer notch signaling pathway conversely hsa mir may inhibitor pneumonia pathogenesis furthermore hsa mir might promote pneumonia via targeting kalrn
determining factors governing investment immunity critical understanding host pathogen ecological evolutionary dynamics studies often consider disease resistance context life history theory expectation investment immunity optimized anticipation disease risk immunity however constrained context dependent fitness costs costs immunity vary across life history strategies yet considered pea aphids typically unwinged produce winged offspring response high population densities deteriorating conditions example polyphenism strategy used many organisms adjust environmental cues goal study examine relationship fitness costs immunity pathogen resistance strength immune response across aphid morphs differ life history strategy genetically identical measured fecundity winged unwinged aphids challenged heat inactivated fungal pathogen found immune costs limited winged aphids hypothesized costs reflect stronger investment immunity anticipation higher disease risk winged aphids would resistant due stronger immune response however producing wings energetically expensive guided alternative hypothesis investing resources wings could lead reduced capacity resist infection measured survival pathogen load live fungal infection characterized aphid immune response fungi measuring immune cell concentration gene expression found winged aphids less resistant mount weaker immune response unwinged aphids demonstrating winged aphids pay higher costs less effective immune response results show polyphenism understudied factor influencing expression immune costs generally work shows addition disease resistance costs immunity vary individuals different life history strategies discuss implications findings understanding organisms invest optimally immunity light context dependent constraints
parliamentary websites become one important windows citizens media follow activities legislatures hold parliaments account therefore parliamentary institutions aim provide new multimedia solutions capable displaying video fragments demand plenary activities paper presents multimedia system parliamentary institutions produce video fragments demand website linked information public feedback helps explain content shown fragments prototype implementation developed canary islands parliament spain shows traditional parliamentary streaming systems enhanced use semantics computer vision video analytics semantic web technologies used make search capabilities parliamentary websites available users retrieve video fragments demand accurate timely information addition video analytic techniques enable automation identifying representative keyframes annotated parliamentary experts result parliaments able enhance citizens access information ensure institutions open andaccountable websites time labor intensive tasks parliamentary experts considerably reduced
fair exchange resources provides basis developing morality yet research rarely examined role group processes central children world article describe new perspective well research demonstrating group processes play key role fair allocation resources among children adolescents contend children allocate resources group processes moral judgments relevant developmental shift occurs children ability coordinate moral group concerns group processes contribute intergroup bias regarding allocations also efforts consider status disadvantaged groups perspective informs efforts reduce prejudice well increase fairness equality situations group processes relevant allocating resources fairly
characteristic issues surrounding parents youth sport include examples negative verbal non verbal behaviour demonstrated competition numerous studies done well highlight parents possess great potential positively influencing sport experience also exert considerable negative influence engaging range non preferred inappropriate behaviours certainly need understand nature sport parenting paradigm given encouraging supportive parental involvement critical factor promoting enjoyment intrinsic motivation among participants particularly important given children preferred parental behaviours temporally dependent different types parental involvement preferred competitive sport however one aspect parental involvement youth sport largely overlooked post game setting drawing qualitative data derived focus groups individual interviews parents children involved junior australian football paper reveals aspect sport parenting role enhance undermine youth sport experience specifically reveals intriguing insight way parents engage debriefing children performancesrepresenting challenge parents strive engender positive supportive influence youth sport concept sport parenting receives much attention within competitive setting paper argues order enhance quality parental involvement youth sport much learnt exploring happens game
based structural reliability theory extreme wind speed forecast method used establish reliability model analyzing aerostatic instability long span suspension bridge limit state equation reliability analysis model function conversion factor critical wind speed aerostatic instability gust factor extreme wind speed bridge site paper method based first order second moment reliability theory used calculate reliability indices aerostatic instability suspension bridge results indicate probability assessment reliability analysis aerostatic instability suspension bridge stochastic wind loading based bayesian theory precise practical valuable engineering application
space debris special kind fast moving near earth objects also considered interesting topic time domain astronomy optical survey main technique observing space debris contributes much studies space environment however due motion registered objects image degradation critical optical space debris observations affects efficiency data reduction lowers precision astrometry therefore image restoration form deconvolution applied improve data quality reduction accuracy promote image processing optimize reduction image degradation across field view modeled statistically principal component analysis efficient mean point spread function psf derived raw images used image restoration test efficiency reliability trial observations made low earth orbital high earth orbital objects positions targets measured using novel approach compared reference positions performance image restoration employing estimated psf compared several competitive approaches proposed image restoration outperformed others influence image degradation distinctly reduced resulted higher signal noise ratio precise astrometric measurements
background visual effects illusions occur prolonged viewing visual displays motion effect mae example illusory impression motion viewing moving displays subsequently stationary displays appear drift opposite direction effects used extensively basic vision research clinical settings enhanced migraine objective objective article assess associations mae duration visual symptoms experienced migraine headache attacks visual stimuli reported migraine headache triggers methods mae elicited viewing motion seconds mae duration tested three test contrast displays high medium low participants also completed headache questionnaire included migraine headache triggers results test contrast mae prolonged migraine mae duration associated photophobia visual triggers flicker striped patterns migraine headache frequency conclusions group differences various visual tasks attributed abnormal cortical processing migraine hyperexcitability heightened responsiveness lack intra cortical inhibition results consistent hyperexcitability simply general lack inhibition alternative multi stage models discussed suggestions research recommended including visual tests clinical assessments clinical trials
mechanomutable asphalt binders able modify mechanical behavior activated magnetic field effect magnetic field binders increase stiffness perform elastically magnetic field removed material recovers original visco elastic properties fact smart materials could offer wide range interesting engineering applications one use could incorporation structures required support cyclic loading asphalt pavements punctually activated minimize impact traffic loads based considerations paper studies mechanical performance mechanomutable asphalt binders cyclic loads similar occurring real pavements service life purpose magneto rheometer used carry different multiple stress creep recovery tests different magnetic field strength results obtained show spite fact binders significant recovery capacity reduce cumulative permanent deformations produced due effect cyclic loads effect magnetic field elsevier ltd rights reserved
pair programming two developers share computer work together developing one piece code test pair programming effects students behavior middle eastern society interaction restrictions found devised empirical study carried entire academic year consists two semesters study targeted two sections per semester advanced computer programming course students one sections worked pairs lab sessions applying pair programming rules techniques section students worked individually norm programming labs video recordings recorded throughout lab sessions studied analyzed preliminary results revealed pair programming potential increase students confidence enjoyment course improved course completion rate
fluctuation conductivity experimentally studied genuine critical region near superconducting transition ybacuo delta ybacu delta bacuo delta single crystal samples two fluctuation regimes electrical conductivity diverges power law reduced temperature systematically observed first regime farther critical temperature transition behaves predicted thermodynamics three dimensional universality class characteristic second order phase transition asymptotic regime closer power law regime characterized much smaller exponent observed smallest value ever reported fluctuation conductivity exponent high superconductors obtained doped systems suggest regime beyond crossover towards weakly first order transition induced internal magnetic excitations elsevier rights reserved
geotextiles placed subbase subgrade order enhance bearing capacity soft subgrades concentrated forces perpendicular plane geotextile result subgrade surface irregularities impart axi symmetric loading geotextile study simple model axi symmetric tensile strength anisotropic hybrid needlepunched nonwoven geotextiles proposed relating plane tensile properties obtained wide width tensile tests weaker direction range hybrid geotextiles produced blend polypropylene viscose fibers defined weight proportions validate model axi symmetric tensile strength general good correlation observed theoretical experimental results axi symmetric tensile strength hybrid needlepunched nonwoven geotextiles elsevier ltd rights reserved
background children autism often present myriad possible sensory processing deficits sensory based subtypes proposed means better understand unique sensory qualities clinical population purpose systematic review synthesize information sensory based subtypes reported literature children autism methods prisma guidelines informed review process included articles published last years specific children autism ages years old articles meeting eligibility full text review matched final inclusion criteria results findings indicate sensory based subtypes children autism developed using primarily parent report instruments assess differences sensory responsivity several different subtyping schemes presented suggesting three five subtypes appropriate fit encompass different patterns sensory responsivity seen children autism several studies suggest subgroup population typical sensory functioning subgroup exists significant global sensory differences mixed results found children fall specific versus global differences responsivity hyper hyporesponsivity sensory seeking within specific sensory domains conclusion literature consists small number descriptive studies little consensus subtypes initial findings indicate service providers may able consider variable presentations sensory processing differences approach treatment intervention planning research indicated elsevier ltd rights reserved
versatility fuel cells enables wide range applications usually fuel cells combined stacks reactant supply single cells achieved via pipe branching system manifold overall performance significantly depends cell flow rates related fluidic interaction manifold cells computational fluid dynamics cfd simulations often used find suitable design lack experimental flow data validation numerical results enable flow measurements within small geometries manifold provide reliable velocity information inside real fuel cell stack low coherence laser doppler anemometer lda applied uses multi mode laser light achieve spatial resolution use fluorescent particles backward scatter mode make sensor highly suitable application small manifold geometries like fuel cell stacks sensor measurement technique validated simplified stack models applicability air flows demonstrated finally first time velocity profiles high spatial resolution inside operated fuel cell stack presented serve benchmark cfd find optimal geometry elsevier rights reserved
objectives purpose study investigate whether motivational climates differential impact adolescent psychological physiological stress responses salivary cortisol important investigate relationship psychological stress stress responsive hormones implicated variety biochemical processes deleterious mental physical health although youth consistently respond positively caring task involving physical activity settings ego involving climates remain prevalent youth sport contexts design middle school students separated gender randomly assigned either min instructional juggling session method salivary cortisol measured four times study including one baseline min juggling session start three response measures min psychological stress motivational responses also examined including anxiety affect enjoyment effort individual items utilized substantiate stress perceptions assess psychological responses results results revealed climate procured significant rise salivary cortisol greater humiliation self consciousness shame negative affect anxiety relative group adolescents group responded favorably greater effort enjoyment conclusions findings suggest motivational climate differentially impact adolescents stress responses climates eliciting physiological psychological stress responses youth contrast climates may buffer performance related stressors accompany group achievement settings yield protective response elsevier ltd rights reserved
test generation still problem design testability fault diagnosis analog circuits paper approach sensitivity analysis based signal flow graph sfg presented analyzed firstly design technique testability studied detail terms approach furthermore prototype system testing design using prolog matlab presented approach design system verified classical band pass filter circuit signal condition circuits dynamic tuned gyroscope dtg experimental results show efficiently used design testability kind analog circuits
article describes application object called smart lamp control thermal comfort real working conditions implemented following diy approach using microcontroller low cost sensors printer idea beyond smart lamp concept smart environments sensors actuators interact aim improving human well device upgrades smart way commercial desk lamp usually available offices allows optimize indoor thermal comfort energy consumption interacting directly heat pump order evaluate person office thermal comfort energy consumption improvements due better management cooling system smart lamp tested results showed application device effectively optimized thermal comfort energy consumption authors published elsevier ltd
development gnrh neurons differentiate extracerebraly nasal placode migrate vomeronasal organ forebrain along vomeronasal terminal nerves numerous studies described influence different molecules migration gnrh neurons however role microenvironment cells remains poorly understood study used gfap gfp transgenic mice detect glial cells early developmental stages using nasal explant cultures comigration glial cells gnrh neurons clearly demonstrated vitro approach showed glial cells began migrating explants gnrh neurons remained ahead gnrh migratory front stopped migrating gnrh neurons association glial cells axons combined gene expression analysis gfap gfp sorted cells enabled identified olfactory ensheathing cells oec immunohistochemical analysis revealed presence multiple glial cell type markers showing several oec subpopulations surrounding gnrh neurons moreover oec expressed genes whose products involved migration gnrh neurons nelf semaphorin situ data confirmed majority gnrh neurons associated glial cells along vomeronasal axons nasal septum terminal nerves nasal forebrain junction early overall data demonstrate oec microenvironment migrating gnrh neurons mouse development fact glial cell type precedes gnrh neurons encodes molecules involved nasal migration suggests participates gnrh system ontogenesis wiley periodicals inc wiley periodicals inc
analytical methods usually applied tuning fractional controllers present paper proposes empirical method tuning new type fractional controller known pid fractional order filter fof pid indeed setpoint overshoot method initially introduced shamsuzzoha skogestad adapted tuning fof pid controller based simulations range first order time delay processes correlations derived obtain pid fof controller parameters similar obtained internal model control imc tuning rule setpoint overshoot method requires one closed loop step response experiment using proportional controller controller highlight potential method simulation results compared obtained imc method well pertinent techniques various case studies also considered comparison revealed proposed tuning method performs good imc moreover might offer number advantages imc tuning rule instance parameters fractional controller directly obtained setpoint closed loop response data without need model plant controlled isa published elsevier ltd rights reserved
literature children internal body knowledge consistently indicated knowledge body develops orderly sequence increasing age much children currently know internal organs however may influenced increase health body information available school education programmes little recent research area present study aimed provide update australian children currently understand anatomy corroborate developmental trends found previous research one hundred eighty nine school children aged years asked draw interior body body outline provided subset children also interviewed understanding anatomy developmental trends found study broadly consistent reported existing literature children inside body knowledge similar documented children human figure drawing namely children body knowledge understanding increased age although awareness integration internal body parts amongst children present study seemed developed suggested previous studies availability educational resources influencing children knowledge internal organs remains equivocal nevertheless research relevance involved children health awareness education well direct implications paediatric health care procedures
background previously described rover dna variant caller identifies genetic variants pcr targeted massively parallel sequencing mps datasets generated plex protocol rover permits stringent filtering sequencing chemistry induced errors requiring reported variants appear reads overlapping pairs certain thresholds occurrence rover developed tandem plex used successfully screen genetic mutations breast cancer predisposition gene palb rover applied mps data bam format therefore relies sequence reads mapped reference genome paper describe improvement rover called undr rover unmapped primer directed rover accepts mps data fastq format avoiding need computationally expensive mapping stage taking advantage location specific nature pcr targeted mps data results undr rover algorithm achieves stringent variant calling predecessor significant runtime performance improvement one indicative sequencing experiment undr rover fastest mode required fold less sequential computation time rover pipeline fold less sequential computation time variant calling pipeline based popular gatk tool undr rover implemented python runs popular posix like operating systems linux requires input tab delimited format file containing primer sequence information fasta format file containing reference genome sequence paired fastq files containing sequence reads primer sequences end reads associate read pairs targeted amplicon thus expected corresponding coordinates reference genome primer intervening sequence read compared reference sequence location variants identified using algorithm rover specifically variant called must appear location overlapping reads user defined thresholds minimum number reads proportion reads conclusions undr rover provides rapid accurate genetic variant calling predecessor greatly reduced computational costs
photosynthesis research employs several biophysical methods including detection fluorescence even though fluorescence key method detect photosynthetic efficiency applied adapted single cell confocal microscopy measurements examine photosynthetic microorganisms experiments photosynthetic cells may require automation perform large number measurements different parameters especially concerning light conditions however commercial microscopes support custom protocols time controller offered olympus experiment designer offered zeiss often unable provide special set ups connection external devices irradiation new system combining arduino microcontroller cell finder software developed controlling olympus confocal microscopes attached hardware modules software hardware solution offers text file based macro language control imaging functions microscope programmable control several external hardware devices light sources thermal controllers actuators imaging via arduino microcontroller cell finder software ergonomic user environment fast selection method biologically important cells precise positioning feature reduces unwanted bleaching cells scanning laser cell finder downloaded http www alga cellfinder system applied study changes fluorescence intensity synechocystis pcc cells long term illumination thus able describe kinetics phycobilisome decoupling microscopy data showed phycobilisome decoupling appears slowly long term exposure high light
bacterial community structure diversity assessed scale rotating biodisk procedure semiindustrial pilot plant well salmonella community particularly monitored effects ultraviolet bacterial community studied identification dominant bacteria revealed presence beneficial useful species could play important role process wastewater purification several species enterobacter agglomerans cronobacter sakazakii pantoea agglomerans known bioremediation activities revealed majority biofilm samples common detection salmonella community provides evidence system seriously affect salmonella furthermore investigation inactivation whole bacterial community secondary treated wastewater showed variable resistance results salmonella detection registered dose around since total disappearance salmonella recorded
paper present novel error measure compare computer generated segmentation images volumes ground truth measure call tolerant edit distance ted motivated two observations usually encounter biomedical image processing errors like small boundary shifts tolerable practice errors tolerable application dependent explicitly expressible measure non tolerable errors corrected manually effort needed reflected error measure measure minimal weighted sum split merge operations apply one segmentation resembles another segmentation within specified tolerance bounds contrast commonly used measures like rand index variation information integrate small tolerable differences additionally ted provides intuitive numbers allows localization classification errors images volumes demonstrate applicability ted segmentations neurons electron microscopy images topological correctness arguable important exact boundary locations furthermore show ted limited evaluation tasks use loss function max margin learning framework find parameters automatic neuron segmentation algorithm show training minimize ted minimize crucial errors leads higher segmentation accuracy compared learning methods published elsevier inc
whereas significant advances made understanding exposure early adversity gets skin children result long term changes developmental outcomes processes positive social relationships become biologically embedded remain poorly understood aim study understand pathways maternal infant social environments become biologically embedded infant cortisol reactivity two hundred seventy two pregnant women infants prospectively assessed pregnancy months postpartum serial mediation analyses higher perceived social support partners pregnancy associated lower infant cortisol reactivity larger decreases cortisol response stressor months age via lower self reported prenatal maternal depression higher mother infant interaction quality findings add understanding perinatal social relationships become biologically embedded child development
technology monitoring operating state architecture construction always hot topics civil engineering paper attempts using nitisma film ferroelectric ceramics pzt composite materials function force electricity conversion introduced design structural safety monitoring system sensing materials based function force electricity conversion directly perceive stress changes architectural structure vibration loads monitoring state changes internal cracks architectural structure results show safety monitoring system architectural beam structure sense nitisma film ferroelectric ceramics pzt composite materials possesses reaction speed milliseconds response frequency suitable monitoring damage status cracks architecture construction
purpose combined intraoperative monitoring iom transcranial electric motor evoked potentials tce meps somatosensory evoked potentials sseps safe effective spinal cord monitoring scoliosis surgery however literature data regarding reliability spinal cord monitoring patients neuromuscular scoliosis conflicting need confirmed methods reviewed iom records consecutive patients neuromuscular scoliosis related central nervous system cns pts peripheral nervous system pns patients diseases underwent posterior fusion instrumentation surgery spinal deformity multimodalitary iom sseps tce meps performed results spinal cord monitoring using least one modality attempted patients falsenegative results present either group relatively high incidence false positive cases noted cns group two patients cns group one patient pns group presented transient postoperative motor deficits true positive related surgical manoeuvres two cases malposition one conclusions multimodalitary iom safe effective detect impending spinal cord peripheral nerves dysfunction neuromuscular scoliosis surgery however interpretation neurophysiological data may challenging patients rate false positive results high pre operatory motor deficits severe
aims objectives evaluate caregiver burden factors influence burden among caregivers patients alzheimer disease china background long term care reduce quality life caregivers result mental physical exhaustion however little known caregiver burden associated factors china design study quantitative cross sectional design methods total caregivers patients included study patients cognitive psychological functional status caregivers burden sleep quality mental state evaluated descriptive analyses single factor regression stepwise factor regression used determine effects various factors caregiver burden results older females spouses still play important role providing family care dementia caregivers sole full time caregiver little time sleepiness common physical problem caregivers moderate severe depression anxiety lower functional status patient associated higher caregiver burden poorer physical status compared caregiving began lower life satisfaction higher degrees depression anxiety associated higher caregiver burden conclusion depression anxiety sleep problems main challenges faced family caregivers patients alzheimer disease caregivers functional status lower life satisfaction depression anxiety influenced caregiver burden caregiver burden related severity patient dementia personal factors caregivers relevance clinical practice provide information caregivers current status caring patients alzheimer disease understand caregiver burden related factors professionals work alzheimer disease pay attention caregiver burden especially mental physical problems
background cutaneous adverse events important negative influence quality life compliance affected patients palmoplantar erythrodysesthesia ppe hand foot syndrome cutaneous toxicity associated chemotherapeutic treatment necessitates treatment interruption dose reduction severe cases case report pegylated liposomal doxorubicin induced ppe shows influence mechanical stress development skin lesions various locations importance patient education compliance case report present case year old female patient diagnosed ovarian cancer undergone surgical chemotherapeutic treatment development extensive grade ppe affecting numerous areas body particularly exposed mechanical pressure necessitated dermatological treatment combination local application antioxidant containing ointment patient compliance made possible continue chemotherapy without interruption dose reduction conclusion development ppe often limits use chemotherapeutic agents case report provide possible therapeutic preventive strategy affected patients
landslides move slowly intermittently downslope others liquefy early stages motion leading runaway acceleration high speed runout across low relief terrain mechanisms responsible disparate behaviour represented two phase depth integrated landslide dynamics model melds principles soil mechanics granular mechanics fluid mechanics model assumes gradually increasing pore water pressure causes slope failure nucleate weakest point basal slip surface statically balanced mass failure spreads adjacent regions result momentum exchange liquefaction contingent pore pressure feedback depends initial soil state importance feedback illustrated using model study dynamics disastrous landslide occurred near oso washington usa march alternative simulations event reveal pronounced effects landslide mobility bifurcation occurs initial void ratio water saturated soil equals lithostatic critical state void ratio also show tendency bifurcation increases soil permeability decreases bifurcation implies difficult discriminate conditions favour slow landsliding favour liquefaction long runout
prma packetized multiple access scheme transmitting short range radio channels promising scheme implement cellular system prma requires little central control allows hand overs minimal base station intervention however mobile voice terminals move one cell another forfeit slots reserved addition encounter hand delays leading dropping voice packets main problem mobile terminal lose packets even secured reservation paper use path enumeration technique using signal flow graphs combined equilibrium point analysis analyze effect terminal mobility performance prma cellular environment
objective aim study assess association polyunsaturated fatty acids pufas inflammatory biomarkers among patients secondary prevention cardiovascular disease cvd methods cross sectional substudy balance program trial collected data patients established cvd twenty four hour dietary recalls plasma concentrations analyzed estimate intake inflammatory biomarkers measurement consisted interleukin beta reactive protein adiponectin tumor necrosis factor alpha log transformation inflammatory biomarkers multivariate adjusted general linear model used examine effect intake association adjusted body mass index waist circumference energy smoking status age total cholesterol low density lipoprotein cholesterol physical activity calcium channel blockers results pufas inversely associated reactive protein levels beta increase kcal pufas omega omega reduces average respectively mean concentration beta conclusion omega omega intakes inversely associated inflammatory biomarkers among cvd patients additional studies omega omega intake relation inflammatory biomarkers patients secondary prevention cvd needed particularly regarding dietary patterns rich sources pufa elsevier inc rights reserved
phenylpropanoid pathway plants responsible biosynthesis huge amount secondary metabolites derived phenylalanine tyrosine flavonoids lignins synthesized end diverse metabolic pathway well many intermediate molecules whose precise biological functions remain largely unknown diversity molecules increased action udp glycosyltransferases ugts leading production glycosylated hydroxycinnamates related aldehydes alcohols esters glycosylation change phenylpropanoid solubility stability toxic potential well influencing compartmentalization biological activity glycosylation therefore represents extremely important regulation point phenylpropanoid homeostasis article review recent knowledge enzymes involved regulating phenylpropanoid glycosylation status availability different subcellular compartments also examine potential link monolignol glycosylation lignification exploringco expression lignin biosynthesis genes phenolic glycosylation genes different biological roles linked particular chemical properties phenylpropanoids often correlated plant stress management strategies also regulated glycosylation ugts instance influence resistance plants infection microorganisms involved mechanisms related environmental changes impact flavonoid glycosylation color flowers leaves seeds fruits also discussed altogether paper underlies fact glycosylation deglycosylation powerful mechanisms allowing plants regulate phenylpropanoid localisation availability biological activity
paper provides information improvement weak clay soil geotextile encased stone columns paper presents materials relevance technology applying perm region russia article presents overview analysis existing experimental studies subject allows identifying area current study aim applying technology improve weak bases foundations buildings structures geological condition perm region also paper considers problem estimating deformations improves soil base experimental studies consist tests use triaxle equipment stamp tests big scale models geotextile encased stone columns conclusions effectiveness geotextile encased stone columns made base results experimental studies analysis existing materials also paper presents areas possible cost effective application technology results numerical simulation test cases using finite element method
paper deals constructing general exact solutions coupled higgs equation using expansion expansion methods obtained solutions expressed three types functions hyperbolic trigonometric rational functions free parameters shown suggested methods productive used solve nonlinear partial differential equations applied mathematics engineering throughout paper calculations made aid maple software
syndrome common chromosomal disorder causing mental retardation worldwide average prevalence cases per births study aimed determine comorbidities associated coverage health care services developmental interventions livebirths southern thailand total livebirth infants recruited prospective birth defects registry system provinces southern thailand regularly followed every months data collection form included infants demographic data associated congenital anomalies developmental interventions infants born average gestational age weeks average birth weight length head circumference congenital heart diseases gastrointestinal defects congenital hypothyroidism found cases respectively percentage infants received developmental interventions current study significantly greater previous study covering years early stimulation program speech training program respectively infants study began intervention programs significantly earlier years years respectively congenital heart disease common comorbidity associated coverage health care services developmental interventions children generally improved southern thailand one hundred percent coverage health services interventions children special needs expected near future
tobacco smoking risk factor several cancers yet roles putative etiologic exposure poor prognostic factor breast cancer less clear altered dna methylation contributes breast cancer development may provide mechanistic link smoking gene expression changes leading cancer development progression using cancer focused array examined methylation cpgs invasive breast tumors carolina breast cancer study determine whether methylation patterns differ exposure tobacco smoke multivariable generalized linear regression models used compare tumor methylation profiles smokers never smokers overall stratified hormone receptor status modest differences cpg methylation detected breast tumors current ever smokers compared never smokers stratified analyses tumors smokers exhibited primarily hypomethylation compared tumors never smokers hypomethylation similarly detected within homogeneous basal like subtype current smoking associated cpg loci exhibited methylation levels former smokers intermediate current never smokers exhibited progressive changes methylation increasing duration smoking among former smokers restoration methylation toward baseline never smoking levels observed increasing time since quitting moreover smoking related hypermethylation stronger breast tumors blacks whites results suggest breast tumor methylation patterns differ tobacco smoke exposure however additional studies needed confirm findings
inverted pendulum control problem classical benchmark control theory amongst approaches developing control programs inverted pendulum evolution artificial neural network ann based controllers received attention authors previously shown evolutionary robotics successfully used evolve inverted pendulum stabilization controllers simulation controllers transfer successfully simulation real world robotic hardware process use made robotic simulators constructed empirically collected data based anns current work aims compare method simulator construction traditional method building robotic simulators based physics equations governing robotic system consideration order compare ann based physics based simulators evolution inverted pendulum controllers real world wheeled inverted pendulum robot considered simulators based anns well system ordinary differential equations describing dynamics robot developed two simulation techniques compared using simulation based evolution controllers evolution process effects injecting different levels noise simulation furthermore studied encouraging results obtained controllers evolved using ann based simulators realistic levels noise outperforming evolved using physics based simulators
objectives examine independent associations television computer video game use physical violence youth methods study population consisted representative cross sectional sample canadian youth grades year longitudinal sample youth grades number weekly hours watching television playing video games using computer determined violence defined engagement physical fights previous year perpetration monthly episodes physical bullying logistic regression used examine associations results cross sectional sample computer use associated violence independent television video game use video game use associated violence girls boys television use associated violence controlling screen time measures longitudinal sample video game use significant predictor violence controlling screen time measures conclusions computer video game use screen time measures strongly related violence large sample youth
light profound effects mood exemplified seasonal affective disorder sad beneficial effects bright light therapy however underlying neural pathways light regulates mood well understood previous work developed diurnal grass rat arvicanthis niloticus animal model sad leach utilizing dim light dark dld paradigm simulates lower light intensity winter showed animals housed dld exhibited increased depression like behaviors forced swim test fst sweet solution preference ssp compared animals housed bright light day bld objective present study test hypothesis light affects mood acting brain orexinergic system diurnal grass rat model sad first orexin immunoreactivity oxa examined dld bld grass rats results revealed reduction number oxa neurons hypothalamus attenuated oxa fiber density dorsal raphe nucleus animals dld compared bld group animals bld treated systemically selective orexin receptor oxr antagonist led depressive phenotype characterized increased immobility fst decrease ssp compared vehicle treated controls results suggest attenuated orexinergic signaling associated increased depression like behaviors grass rats support hypothesis orexinergic system mediates effects light mood ibro published elsevier ltd rights reserved
collecting representative data sensitive issues long problematic challenging public health prevalence investigation non suicidal self injury medical research drug habits social issue studies history child abuse interdisciplinary studies premarital sexual intercourse alternative data collection techniques adopted study sensitive questions validly become important necessary alternative famous warner randomized response model non randomized response triangular model recently developed encourage participants provide truthful responses surveys involving sensitive questions unfortunately randomized non randomized response models could underestimate proportion subjects sensitive characteristic respondents believe techniques protect anonymity result authors hypothesized lack trust noncompliance highest among lose least use anonymity provided using techniques researchers noticed existence noncompliance proposed new models measure noncompliance order get reliable information however proposed methods based randomized response models require randomizing devices restrict survey face face interview lack reproductivity taking noncompliance consideration introduce new non randomized response techniques covariate required asymptotic properties proposed estimates sensitive characteristic well noncompliance probabilities developed proposed techniques empirically shown yield accurate estimates sensitive noncompliance probabilities real example premarital sex among university students used demonstrate methodologies
distributed systems big data management often face problem load imbalance among nodes address issue exist almost many load balancing strategies different systems designing scalable distributed system geared towards handling large amounts information often easy anticipate kind strategy efficient maintain adequate performance regarding response time scalability reliability time based observation describe generic api implement experiment strategy independently rest code prior definitive choice instance show existing load balancing strategies used famous systems could implemented api also present work helped implement load balancing distributed system modify behavior strategy lines code led easily perform various experiments determine efficient scheme system paper extension work presented workshop parallel distributed computing big data applications wpba detail experiments extend use api broad class big data storage systems copyright john wiley sons ltd
present supervised machine learning approach markerless estimation human full body kinematics cyclist unconstrained colour image approach motivated limitations existing marker based approaches restricted infrastructure environmental conditions obtrusive markers using discriminatively learned mixture parts model construct probabilistic tree representation model configuration appearance human body joints learning stage structured support vector machine ssvm learns body parts appearance spatial relations testing stage learned models employed recover body pose via searching test image pyramid structure focus movement modality cycling demonstrate efficacy approach natura estimation cycling kinematics using images challenging human interaction bicycle causing frequent occlusions make assumptions relation kinematic constraints model appearance scene technique finds multiple quality hypotheses pose evaluate precision method two new datasets using loss functions method achieves score mean probability correct keypoint pck measure average precision keypoints apk measure frontal sagittal datasets respectively conclude method opens new vistas robust user interaction free estimation full body kinematics prerequisite motion analysis elsevier ltd rights reserved
arctic antarctic latitudes personnel deprived natural sunlight winter continuous daylight summer light sufficient intensity suitable spectral composition main factor maintains period human circadian rhythms thus status circadian system interest moreover relatively controlled artificial light conditions winter conducive experimentation different types light treatment hormone melatonin metabolite sulfatoxymelatonin amts provide probably best index circadian seasonal timing frequent observation delay circadian system winter skeleton photoperiod bright white light morning evening restore summer timing single pulse light morning may sufficient people desynchronize day free run show intrinsic circadian period usually regard general health polar regions intermittent reports describe abnormalities various physiological processes point view daily seasonal rhythms positive health outcomes also published true winter depression sad appears rare although subsyndromal sad reported probably concern numerous reports sleep problems prompted investigations underlying mechanisms treatment interventions delay circadian system normal working hours implies sleep attempted suboptimal phase decrements sleep efficiency latency duration quality also seen winter increasing intensity ambient light exposure throughout day advanced circadian phase associated benefits sleep blue enriched light slightly effective standard white light effects performance remain fully investigated base personnel adapt circadian system night work within week contrast temperate zones complete adaptation rarely occurs similar situation occurs high latitude north sea oil installations especially working lack conflicting light exposure social obligations probable explanation many problems returning day work showing circadian desynchrony timed light treatment helped restore normal phase sleep small number people postprandial response meals compromised periods desynchrony evidence insulin resistance elevated triglycerides risk factors heart disease small numbers subjects studied intensively polar regions however observations suggest suboptimal light conditions deleterious health apply equally people living temperate zones insufficient light exposure author correspondence arendtjo gmail com
research discusses recent developments applications high strength prefabricated parallel wire strand ppws tensile strength mpa cost efficiency high strength ppws cables briefly reviewed performance requirements newly developed wire ppws cable proposed referring existing specifications building codes acceptance tests performed wire ppws cable specimens results confirmed ppws cables sufficient strength used main cables ulsan harbor bridge long span suspension bridge currently construction korea mass production system ppws cable recently implemented korea outlined describing notable aspects equipment manufacturing process believe high strength ppws combined efficient mass production system described study provide economical solution aspects concerning main cables long span suspension bridges
door face ditf sequential message strategy investigated threestudy analysis existing experimental findings current study predicted would positive relationship concession size compliance rates ditf studies study included comparisons size concession quantifiable measured percentage reduction initial target request ditf condition study data relied panel undergraduate students provide index concession size additional observations third study validated panel procedure rating concession size also provided additional independent observations pool published studies ditf results study indicated positive relationship concession size effect size respectively study findings provide support reciprocal concessions explanation ditf effects
past decades witnessed surge interests learning distance metrics various image processing tasks however facing features multiple views metric learning methods fail integrate compatible complementary information multi view features train common distance metric information thrown away single view methods affects performances severely therefore fully exploit information multiple views construct optimal distance metric vital importance challenging address issue paper constructs multi view metric learning method utilizes divergences integrate features multiple views minimizing divergence features different views lead consistency multiple views enables mml exploit information multiple views various experiments several benchmark multi view datasets verified excellent performance novel method elsevier rights reserved
stress plays important role major depressive disorder mdd one state dependent factors suicidal behavior dysfunctional hypothalamic pituitary adrenal axis common feature disorder involvement environmental factors added additional complexity understanding depression suicidal behavior regard epigenetic regulation considered mechanistic interface environmental stress stimuli altered functioning underlying gene network may increase susceptibility depression suicidal behavior present study examined whether epigenetic modifications stress related genes associated mdd whether differences epigenetic marks depressed individuals without serious suicidal ideation using medip analysis genomic dna isolated peripheral blood mononuclear cells pbmc healthy controls mdd patients without serious suicidal ideation studied methylation stress associated genes brain derived neurotrophic factor bdnf nuclear receptor subfamily group member nrc binding protein fkbp corticotropin releasing hormone binding protein crhbp corticotropin releasing hormone receptor crhr addition determined transcript levels rnas isolated pbmc found bdnf fkbp crhbp nrc gene promoters significantly hypermethylated mdd patients without suicidal ideation also found concomitant reductions expression bdnf fkbp transcript variants nrc genes patients suggesting promoter hypermethylation genes may functionally associated observed downregulation mdd patients secondary analysis methylation genes compared mdd patients without serious suicidal ideation controls mdd serious suicidal ideation significantly different controls mdd without although mdd without suicidal ideation different likely owning relatively small sample size thus findings underline importance epigenetic modifications stress associated genes depression possibly suicidal behavior future needs confirmed larger patient population elsevier ltd rights reserved
triboelectric generators directly transform energy living environment electricity self powered component wearable devices flexible transparent triboelectric generators fttgs high output power densities urgently needed wearable electronics introducing graphene indium tin oxide ito transparent electrodes optimizing electrode structure fttg polyimide polyethylene terephthalate pet friction layers graphene ito top bottom electrode obtained large output power density wcm four times larger previously reported fttgs wcm moreover output voltage graphene based fttg large exhibits excellent cycling behavior effects electrode structure performance fttg analyzed corresponding mechanism discussed light emitting diodes led easily powered fttg suggesting potential application harvesting electrical energy human activities using flexible transparent devices
computational thinking gaining new impetus academic community level education scratch visual programming environment utilized teach learn introductory computing concepts studies investigating effectiveness scratch level education however studies conducted collegiate level especially context preservice computing teacher education rare present study aimed investigate effect scratch based instruction preservice teachers understanding basic programming concepts attitudes toward programming present study mixed method design utilized first phase study data collected using achievement test practice test computer programming attitude scale second phase study data collected semistructured interview results study indicated preservice teachers scratch based instruction significantly better understanding basic computing concepts qualitative data indicated scratch based instruction useful constructing meaningful learning environment preservice teachers results study implications researchers preservice computing teacher educators designing introductory computing course
new molecularly targeted therapeutics changing dermatologic therapy janus kinase signal transducer activator transcription jak stat intracellular signaling pathway upon many different proinflammatory signaling pathways converge numerous inflammatory dermatoses driven soluble inflammatory mediators rely jak stat signaling inhibition pathway using jak inhibitors might useful therapeutic strategy diseases growing evidence suggests jak inhibitors efficacious atopic dermatitis alopecia areata psoriasis vitiligo additional evidence suggests jak inhibition might broadly useful dermatology early reports efficacy several conditions jak inhibitors administered orally used topically represent promising new class medications use jak inhibitors dermatology reviewed
objectives reported obtaining adduction abduction strength ratio adduction strength equal uninjured side suitable clinical milestones return sport following groin injury little known hip adduction abduction strength profiles australian footballers study aimed compare isometric hip adduction abduction strength profiles preferred non preferred kicking legs elite sub elite amateur australian footballers design cross sectional study methods elite sub elite amateur australian footballers mean age years respectively included maximal hip isometric adduction abduction strength measured using hand held dynamometer external belt fixation results significant differences isometric hip adduction abduction strength adduction abduction ratio preferred non preferred kicking legs regardless playing level elite players significantly greater isometric hip adduction abduction strength sub elite mean difference adduction abduction amateur players mean difference adduction abduction significant difference adduction abduction ratio playing levels conclusions significant differences found preferred non preferred kicking legs across playing levels isometric hip adduction abduction adduction abduction ratio may implications developing groin injury prediction return sport criteria australian footballers sports medicine australia published elsevier ltd rights reserved
real time simulation smoke sense reality hotspot difficulty research field computer graphics based improved particle system method carried real time simulation smoke joined stable role wind article improved method map smoke strong sense reality improve efficiency achieved requirements
impact simulated embodied agent emotion explored short term studies work date examined impact longer interactions involve multiple interactions agents present embodied agent rachael simulates health professional attempts help people improve fruit vegetable consumption emotional unemotional versions agent developed examine user perceptions agent changed intervention period days turn influenced fruit vegetable consumption results found whilst participants consumed daily portions fruit vegetables intervention period reduced consumption gains post intervention significant difference consumption gains time interacted emotional unemotional agents qualitative feedback however highlighted strong preference emotional agent novelty effect also observed agents perceived positively initially less time
identification nonlinear spatiotemporal dynamical systems given partial differential equations attracted lot attention past decades several methods searching principle based algorithms partially linear kernel methods coupled lattice methods developed address identification problems however existing methods restrictions sampling processes sampling intervals usually small uniformly distributed spatiotemporal domains actually applicable practical applications paper tackle issue novel kernel based learning algorithm named integral least square regularization regression ilsrr proposed used effectively achieve accurate derivative estimation nonlinear functions time domain technique discretization method named inverse meshless collocation developed realize dimensional reduction system identified thereafter novel inverse meshless collocation model ilsrr multiple kernel based learning algorithm multistep identification method systematically proposed address identification problem spatiotemporal systems pointwise nonuniform observations numerical studies benchmark systems necessary discussions presented illustrate effectiveness advantages proposed method
research aims discovering traits abilities characterize ideal leaders minds employees iranian context employing strategy phenomenology reach components ideal leadership tenured middle managers employees possessing decent management knowledge context interviewed theme analysis global basic organizing themes extracted results showed whole themes could categorized two groups prototypes anti prototype five themes prototypes labeled charismatic humane oriented employee servant emotionally mature decisive three anti prototype labeled selfish deceptive narrow minded although components implicit leadership theories ilts generalizable context produce distinct features ilts research tried discover implicit leadership theories iranian context according available themes literature ilts employee servant emotionally mature decisive three novel prototypes deceptive narrow minded new anti prototypeanti prototype moreover first study using interview discover ilts inclusion data retrieved participants semantic memory
insufficiency current energy sources elevated costs global climate worriment distinctive factors making renewable energy issue boosting consideration concern solar energy viewed indefinitely environmental friendly carbon free beneficial nature appreciated cost potentials witnessing fast progressing following horizon climate energy package volume gases emitted greenhouses cut european union member countries order enhance energy performance raise renewable energy rate solar energy building roofs plays crucial aspect renewable sustainable energy consumption high density human habitats merest energy allocated provide hot water service solar sources european norms new buildings spanish technical building code similarly european regulation achievement objectives climate zone overall demand hot water building regulate minimal amount needed manuscript use new methodology automatic detection geometric patterns aerial space images using hierarchical temporal memory htm algorithm way automatic method identification building roofs order assess opportunities available install solar thermal systems small urban areas developed case study village inhabitants analyzed south spain maximum overall accuracy obtained among different classifications made avoiding problems related use images high spatial resolution salt pepper noise effect approach contributes reducing generated carbon ghg emissions open new perspectives energy savings strategies optimize energy efficiency buildings case study implementing solar thermal systems would come saving tons per inhabitant elsevier ltd rights reserved
paper new chaos based partial image encryption scheme based substitution boxes box constructed chaotic system linear fractional transform lft proposed encrypts requisite parts sensitive information lifting wavelet transform frequency domain based hybrid chaotic maps new box proposed encryption scheme characteristics confusion diffusion accomplished three phases block permutation substitution diffusion used dynamic keys instead fixed keys used approaches control encryption process make attack impossible new box constructed mixing chaotic map lft insure high confidentiality inner encryption proposed approach addition hybrid compound box chaotic systems strengthened whole encryption performance enlarged key space required resist brute force attacks extensive experiments conducted evaluate security efficiency proposed approach comparison previous schemes proposed cryptosystem scheme showed high performances great potential prominent prevalence cryptographic applications elsevier ltd rights reserved
dynamic particle swarm optimization learning strategy dpso proposed key parameter estimation permanent magnet synchronous machines pmsms voltage source inverter vsi nonlinearities taken account parameter estimation model estimated simultaneously machine parameters dpso algorithm novel movement modification equation variable exploration vector designed effectively update particles enabling swarms cover large areas search space large probability thus global search ability enhanced moreover gaussian distribution based dynamic opposition based learning strategy developed help pbest jump local optima proposed dpso significantly enhance estimator model accuracy dynamic performance finally proposed algorithm applied multiple parameter estimation including vsi nonlinearities pmsm performance dpso compared several existing pso algorithms comparison results show proposed parameters estimation method better performance tracking variation machine parameters effectively estimating vsi nonlinearities different operation conditions
irritable bowel syndrome ibs like symptoms uncommon patients quiescent inflammatory bowel disease ibd gluten free diet applied patients reported interventional studies low fodmap diet hand efficacy similar seen patients ibs three unblinded observational studies ibd cohorts well controlled inflammatory disease one small randomized cross study fodmap intake patients ibd elevated one study fructan intakes lower patients crohn disease controls clear relationship level fodmap intake intestinal inflammation risk compromising nutritional status restrictive diet must seriously considered especially nutrition already common patient population effects fodmaps gut microbiota patients crohn disease mimic ibs balance prebiosis addition fodmaps loss prebiosis reduction undernutrition common ibd use restrictive diets supervised dietitian thus low fodmap diet viable option ibs like symptoms carefully supervised mitigate risk
main idea structure preserving method preserve intrinsic geometric properties continuous system much possible numerical algorithm design geometric constraint multi body systems one difficulties numerical methods proposed multi body systems also regarded geometric property multi body systems based idea symplectic precise integration method applied paper analyze kinematics problem folding unfolding process nose undercarriage lagrange governing equation established folding unfolding process nose undercarriage generalized defined displacements firstly constrained hamiltonian canonical form derived lagrange governing equation based hamiltonian variational principle finally symplectic precise integration scheme used simulate kinematics process nose undercarriage folding unfolding described constrained hamiltonian canonical formulation numerical results concluded geometric constraint undercarriage system preserved well numerical simulation folding unfolding process undercarriage using symplectic precise integration method
improve actual performance internal combustion engine ice transient behaviors cylinder combustion heat work conversion processes ice investigated optimization method proposed based advanced turbocharged gasoline direct injection tgdi engine steady state bench test load step test constant speed vehicle road test carried basis cylinder combustion heat work conversion processes vehicle engine load step vehicle driving conditions compared steady state results means deviations ice transient performance steady state values demonstrated also impacts revealed research results show satisfactory consistency ice performance especially ignition advance angle load step steady state conditions however vehicle driving conditions operating control parameters gravely deviate steady state values large fluctuations ignition advance angle retarded largely sharp deceleration conditions imep bar ignition advance angle seriously deviates steady state values results large fluctuation combustion characteristic parameters finally leads decrease heat work conversion efficiency moreover fluctuation excess air coefficient one main reasons instability ice transient performance accurately control ignition timing low load decrease fluctuation excess air coefficient effective way improve ice performance vehicle driving conditions elsevier ltd rights reserved
reliability significant performance index electrical equipment industry especially electric motor driven emd systems modelling reliability emd system difficult challenging task however based field data dominant failure modes motor system parts used develop simple credible reliability model study proposes failure rate prediction model emd system currently use hydrocarbon industries addition fault tree model designed identify root causes failures failure mechanism dominates failure modes emd systems accomplish study objectives existing failure databank failures emd systems collected surveyed field historical information failure rate models collected electric motors investigated used model prediction model emd system three competing failure modes found dominate motor life bearing failures winding failures shaft failures mathematical model failure modes dominant variables developed risk failure model established
false memory rejection enhanced individuals rely memorability based inferences remember event well must happened present study investigated whether year olds adults could trained engage memorability based inferences reject false highly familiar increased imagination confabulation events across two experiments participants enacted imagined confabulated series actions differing expected memorability two weeks later half participants received memorability based training administered old new recognition test asked endorse enacted actions thus imagined confabulated actions rejected face high familiarity results indicated adults children exhibited increased rejection false events high memorability following training procedure explained functioning memorability based inferences experiment children rejection familiar events improved training procedure closely mimicked demands retrieval test experiment theoretical practical implications discussed elsevier inc rights reserved
mhz spectrum sensing system designed implemented using cmos technology cognitive radios uhf band based envelope detection system employs converter digitally controlled oscillator low pass filer lpf rectifier comparator digital control unit realize spectrum sensing bit frequency representation variable gain function lpf signal strength measured presented bit signal strength index
study question ulipristal acetate upa used emergency contraception interfere human embryo implantation process summary answer upa dosage used affect human embryo implantation process vitro known already single pre ovulatory dose upa acts delaying inhibiting ovulation recommended first choice among emergency contraceptive pills due efficacy compound also demonstrated dose dependent effect endometrium theoretically could impair endometrial receptivity direct action human embryo implantation yet studied study design size duration effect upa embryo implantation process studied vitro endometrial construct human embryos randomly added cultures cultured days upa vehicle alone record attachment embryos participants materials setting methods endometrial biopsies obtained healthy fertile women cycle day stromal epithelial cells isolated three dimensional vitro endometrial culture system constructed mixing stromal cells collagen covered layer epithelial cells cultured progesterone containing medium confluence treatment group received upa healthy viable human embryos placed control treatment cultures five days later cultures tested attachment embryos endometrial constructs analysed endometrial receptivity markers real time pcr main results role chance significant difference embryo attachment rate upa treated group control group human embryos exposed upa embryos control group attached endometrial cell surface known receptivity genes studied genes hbegf significant regulation genes namely hand opn calcr fgf regulated exposure upa compared control group limitations reasons caution proof concept study conducted human embryos availability limited although model used study well established artificial endometrial luminal epithelium shown express progesterone regulated markers endometrial receptivity still vitro model lacking cell types constitute receptive endometrium vivo wider implications findings study provides new insights mechanism action upa human embryo implantation demonstrating upa dosage used affect embryo viability implantation process embryo progesterone receptor modulators prms hold potential attractive estrogen gestagen free contraceptives thus may made available larger proportion women globally due findings
objective study examines socio demographic clinical characteristics influence suicide risk among large urban sample children ages younger receiving psychiatric emergency services pes methods bivariate binomial logistic regression analyses employed analyze data sample urban children presenting pediatric pes results approximately patients presented history suicidal thought behavior despite larger number black children presenting pes found significant difference suicide risk across ethnic group though prevalence rates increasingly higher whites latinos black respectively presenting suicidality diagnosed behavioral disorder diagnosed mood disorder psychotic disorder another disorder one ten suicidal cases admitted prior child abuse furthermore patients admitted hospital suicidality likely female mood disorder appropriately discharged inpatient setting following initial hospital care conclusions study points importance screening publically insured medicaid urban children experiencing psychological distress regardless ethnicity age suicide risk clinicians consider findings working children psychiatric crisis published elsevier ltd
background spondyloarthritis often affects young people typically working years aim study investigate work productivity relationship disease activity physical functioning italian patients axial spondyloarthritis axspa chronic back pain cbp months years onset years age methods baseline absenteeism presenteeism work productivity loss assessed work productivity activity impairment questionnaire wpai disease activity assessed bath ankylosing spondylitis disease activity index basdai ankylosing spondylitis disease activity score asdas functional ability assessed bath ankylosing spondylitis disease functional index basfi patients axspa rheumatologist diagnosis included italian section spondyloarthritis caught early space cohort collected multivariate linear regression analysis used evaluate associations work productivity disease activity physical functioning results absenteeism patients axspa low decrease work productivity related increase disease activity disease activity strongly correlated absenteeism presenteeism work productivity loss addition decreased work productivity related decrease functional ability physical functioning correlated absenteeism presenteeism work productivity loss months years onset years age
forthcoming directives european commission force homologation altitude approach standards actual driving conditions order reduce gap regulated real life emissions work presents use dedicated atmosphere simulator analyse impact altitude performance emissions turbocharged diesel engine presented equipment provides engine intake exhaust pressure reproduce high altitude conditions main advantages related cost savings respect round robin testing campaigns ensuring controlled ambient conditions different altitudes paper shows main features altitude simulator steady state transient operation ability control temperature time pressure according international standard atmosphere isa specifications experimental results highlight need specific testing facilities perform calibration tasks key tool comply future emission standards cost effective manner particular regulated emissions measured altitude shown clearly exceed permitted sea level emphasizing need explore new dedicated engine control strategies pollutant abatement altitude operation
clean high energy efficient microwave drying system gained popularity wide variety food preservation processing bio commodities main advantage acceleration drying process quite limited comparing conventional hot air drying system however microwave drying process pressure temperature increase continuously might cause undesired side effects degradation physical damages order eliminate mentioned problems enhance higher performance control system flexibility paper design multi stage phase controlled converter microwave drying system proposed objective multi stage power control track drying characteristics microwave drying process different power level depending stage drying cycle period control approach achieved controlling triggering events appropriate phase angle triac based predefined power profiles varying pulse width average power output magnetron controlled focus paper hardware design component selections discussed system flowchart control algorithm based microcontroller arduino mega also presented details experimental results proposed multi stage phased control converter investigated discussed
chronic stressors generally considered disrupt reproduction inhibit mating test hypothesis chronic stressor specifically social isolation facilitate adaptive changes enhance accelerate reproductive effort general monogamous species display high levels prosociality delayed sexual maturation greater parental investment fewer higher quality offspring compared closely related polygynous species predicted chronic social isolation would promote behavioral neurochemical patterns prairie voles associated polygyny male female prairie voles isolated four weeks changes mating behavior alloparental care estrogen receptor expression tyrosine hydroxylase expression brain regions regulating sociosexual behavior examined males isolation accelerated copulation increased alpha medial amygdala meapd bed nucleus stria terminalis bstpm reduced expression meapd bstpm effect alloparental behavior females isolation resulted rapid estrus induction reduced expression meapd bstpm effect estradiol sensitivity era expression results support hypothesis era expression meapd bstpm critical determinant male copulatory behavior mating system lack change alloparental behavior suggests changes prosocial behavior selective regulated different mechanisms results also suggest meapd bstpm may play critical role determining mating behavior sexes elsevier ltd rights reserved
study question association need medical puberty induction diagnosis treatment received girls undergone cryopreservation ovarian tissue fertility preservation summary answer clear association intensity treatment received requirement medical puberty induction association diagnosis known already although predicted girls become infertile develop premature ovarian insufficiency poi following intensive chemotherapy irradiation patients high risk poi offered ovarian tissue cryopreservation otc includes girls planned receive either high doses alkylating agents conditioning regimen stem cell transplantation sct total body irradiation tbi high radiation doses craniospinal abdominal pelvic area study design size duration retrospective cohort study total danish girls years age otc performed period years overview girls diagnoses mean age otc well number deceased presented girls died girls still younger years pubertal development evaluated yet girls otc performed years age incidence poi evaluated group girls younger years otc association diagnosis received treatment requirement medical puberty induction examined participants materials setting methods need medical puberty induction assessed girls prepubertal time otc main results role chance indications otc allogeneic sct leukaemia myelodysplastic syndrome benign haematological disorders autologous sct lymphoma sarcoma irradiation pelvis spinal axis mean age otc girls years two prevalent diagnoses girls malignant tumours malignant haematological diseases among prepubertal girls received high dose chemotherapy either tbi prior sct irradiation pelvis abdomen spinal axis received high dose alkylating agents irradiation prior sct six received alkylating agents part conventional chemotherapy one patient genetic metabolic disorder receive gonadotoxic treatment among girls undergo puberty spontaneously thus received medical puberty induction among nine girls went spontaneous puberty four received high dose alkylating agents five received conventional chemotherapy limitations reasons caution information retrieved retrospectively patient records thus information available wider implications findings otc recommended young girls present high risk developing ovarian insufficiency infertility following high dose chemotherapy irradiation
telehealth offers innovative approach improve heart failure care expands beyond traditional management strategies yet use telehealth heart failure infrequent several obstacles fundamentally evidence inconsistent across studies telehealth interventions heart failure limits ability cardiologists make general conclusions encouraging evidence exists logistical challenges broad scale implementation result insufficient understanding transform telemedicine strategies clinical practice effectively ultimately implementation reasonable application efforts remains hampered regulatory reimbursement policy issues primary aim paper describe challenges outline path forward apply telehealth approaches heart failure conjunction payment reform pragmatic research study design published elsevier behalf american college cardiology foundation
background genome wide association studies assumed additive model inheritance may result significant loss power strong departure additivity general regression model grm allows performing assumption free test association testing additive effect deviation additive effect may appropriate association tests additionally grm allows testing underlying genetic model compared power grm association test additive cochran armitage trend cat tests simulations applying grm large case control sample bipolar welcome trust case control cohort data simulations performed two sets case control samples using large panel genetic models four association tests grm additive recessive dominant cat tests applied replicates results showed grm power detect association similar greater additive cat test particular case recessive inheritance gain power grm analysis genome wide bipolar disorder welcome trust consortium data cases controls showed significant association region identified using additive cat test expected fitted non additive recessive model conclusions grm provides increased power compared additive cat test association studies easily applicable
backgroundcardiovascular cvd complications stemming vascular dysfunction widely explored setting preeclampsia however impact abruption strong indicator microvascular disturbance risk cvd mortality morbidity remains poorly characterised methodswe designed cohort analysis women delivered singletons denmark linked national patient registry registry causes death danish birth registry ascertain cvd events estimated cvd risks relation abruption cox proportional hazards regression following adjustments confounders resultswith person years follow women least one delivery pregnancies complicated abruption median interquartile range follow non abruption abruption groups years respectively cvd mortality rates women without abruption per person years respectively adjusted hazard ratio confidence interval corresponding cvd morbidity complication rates per person years respectively increased risks evident ischaemic heart disease acute myocardial infarction hypertensive heart disease non rheumatic valvular disease congestive heart failure conclusionsthis study shows increased hazards cvd morbidity mortality relation abruption better understanding pathogenesis distorted placental microvasculature needed appears harbinger cvd later life
observation parallels memory distortion persuasion literatures leads quite logically appealing notion people persuaded change memories indeed numerous studies show memory influenced distorted variety persuasive tactics theoretical accounts commonly used researchers explain episodic autobiographical memory distortion phenomena generally predict explain persuasion effects yet despite empirical theoretical overlaps explicit reference persuasion attitude change research memory distortion literature surprisingly rare paper argue stronger theoretical foundations needed draw memory distortion persuasion literatures together productive direction reason theoretical approaches remembering distinguish false beliefs occurrence events false memories events compatible source monitoring approach would beneficial end approaches argue would provide stronger platform use persuasion findings enhance psychological understanding memory distortion
growing interest description short lived patterns spatiotemporal cortical activity monitored via neuroimaging traditional analysis methods designed estimate relatively long term brain dynamics always appropriate capture patterns introduce novel data driven approach detecting short lived fmri brain activity patterns exploiting density peak clustering rodriguez laio approach reveals well localized clusters identifying grouping together voxels whose time series similar irrespective brain location even short time windows similar volumes used method call coherence density peak clustering cdpc first tested simulated data compared standard unsupervised approach fmri analysis independent component analysis ica cdpc identifies activated voxels essentially false positives proves reliable ica troubled number false positives comparable true positives reliability method demonstrated real fmri data simple motor task containing brief iterations movement clusters identified found regions expected involved task repeat synchronously paradigm methodology proposed especially suitable study short time brain dynamics single trial experiments event task interest repeated subject happens instance problem solving learning decision making gui implementation method available download https github com micheleallegra cdpc wiley periodicals inc
second paper two part series presents application developed state space model extraction methodology applied brayton cycle based pcu power conversion unit pbmr pebble bed modular reactor goal investigate state space extraction methodology cope larger complex thermohydraulic systems part state space model extraction methodology purpose control described detail state space representation extracted tube system illustrate concept paper order nonlinear state space representation terms different energy domains extracted state space representation solved responses number important states compared results obtained pbmr pcu flownex model flownex validated thermo fluid simulation software package results show state space model closely resembles dynamics pbmr pcu kind model may used nonlinear mimo multi input multi output type control strategies however still need linear state space models since many control system design analysis techniques require linear state space model issue also addressed paper showing linear state space model derived extracted nonlinear state space model linearised state space model also validated comparing state space model existing linear simulink model pbmr pcu system elsevier ltd rights reserved
secondary metabolites fungi responsible allergies therefore identification compounds produced organisms important fungi produce large amounts secondary metabolites belong groups chemicals dicarboxylic acids hydroxy acids alcohols hydrocarbons esters fatty acids sterols amino acids mycotoxins presence compounds human proximity contributes many diseases therefore aim study qualitative quantitative analysis hydroxy dicarboxylic acids produced fungi occurring student hostel poland province pomerania following species fungi subjected extraction aspergillus niger aspergillus fumigatus aspergillus candidus rhizopus geotrichum candidum penicillium chrysogenum mixture ethyl acetate methanol used extraction obtained extracts analyzed gas chromatography mass spectrometry samples fungi presence total acids including dicarboxylic hydroxy acids confirmed acids different acids identified fumigatus acids identified mycelium candidum niger acids identified samples mycelium hydroxydocosanoic acid hydroxytetracosanoic acid adipic acid abundant compounds hydroxydocosanoic acid fumigatus candidus rhizopus candidum chrysogenum succinic acid niger experiments needed understand physiological role hydroxy dicarboxylic acids hope results important contribution studies human health
recent evidence emerged indicating maternal immune response substantial deleterious impact prenatal development croen biol psychiatry maternal immune response largely sequestered fetus maternal antibodies specifically immunoglobulin igg passed fetus provide passive immunity throughout much pregnancy however protective pathogenic autoantibodies equal access fetus goines van water curr opin neurol mother underlying autoimmune disease reactivity fetal antigens autoantibodies produced pregnancy target tissues developing fetus one tissue fetal brain blood brainbarrier bbb developing fetal period allowing maternal antibodies direct access brain gestation diamond nat rev immunol braunschweig neurotoxicology proposed brain injury circulating brainspecific maternal autoantibodies might underlie multiple congenital developmental disorders lee nat med review discuss current state research area maternal autoantibodies development autism wiley periodicals inc develop neurobiol
objective aim study determine effectiveness voiding dysfunction symptom score vdss evaluation children nocturnal enuresis materials methods four hundred children nocturnal enuresis included study evaluated vdss physical examination urinalysis day voiding diary children nocturnal enuresis symptoms treated desmopressin urotherapy however children overactive bladder symptoms also treated anticholinergics treatment success change vdss compared assessed different treatment methods results two hundred forty five children male female mean age years range mean vdss children nocturnal enuresis concomitant daytime symptoms children vdss nine majority children treated anticholinergic therapy vdss questionnaire could help determine treatment success children non monosymptomatic nocturnal enuresis however children treated urotherapy desmopressine showed significant difference vdsss according treatment response conclusion vdss shown decrease treatment children mono symptomatic nocturnal enuresis treatment strategies checked modified vdss decrease proper therapy would increase success treatment
meta analysis investigates extent people leisure reading may produce better social cognitive abilities researchers hypothesized experiences fiction nonfiction improve readers empathy theory mind capture size effect aggregated correlations measures lifetime reading habits fiction nonfiction measures empathy theory mind consistent previous evidence fiction reading larger correlation social cognitive measures compared nonfiction reading however effects small magnitude heterogeneity analyses indicated effect sizes consistent across studies also examined gender publication status design moderators however none moderators reached significance suggest results meta analysis sanction shift research agenda toward understanding causal mechanisms
paper presents application small hydropower plant shp embedded hydraulic system surge tank relatively low water volume maintain stable surge tank water level author used precisely designed type controller analytical design method called root locus used work new identification method uses step response identify parameters real system described proposed method analytical models hydraulic system turbine well water level controller implemented tested real grid connected shp utilizing treated water wastewater treatment plant results tests conducted substantial variations water flow confirmed stable operation controller maximum water level fluctuations normal operation
effectiveness five global thresholding techniques accurately segment different geomaterials evaluated work ray images taken two phase pervious concrete glass bead silica sand specimens analyzed evaluating five chosen methods core algorithms methods coded using matlab programming language packaged standalone application software three hundred thirty five image slices provided pervious concrete specimen cropped size specimen approximately diameter method proposed kapur yielded best results qualitatively quantitatively laboratory image pro measured void ratios respectively eleven image slices analyzed diameter glass bead specimen method proposed kapur gave best results void ratio compared image pro void ratio ten image slices cropped diameter used analysis silica sand specimen otsu method successful image segmentation technique yielding void ratio image pro results said single image segmentation technique performs well wide range material performance image segmentation technique varies depending type state analyzed media elsevier ltd rights reserved
objective aim study evaluate usefulness mac binding protein glycosylation isomer mbpgi prediction post hepatectomy liver failure phlf hepatocellular carcinoma hcc patients summary background data mbpgi novel serum marker liver fibrosis usefulness mbpgi prediction phlf evaluated methods clinicopathological data analyzed hcc patients underwent liver resection august november phlf evaluated according definition international study group liver surgery performance preoperative parameters predicting phlf determined using receiver operating characteristic roc analysis results serum mbpgi level correlated metavir fibrosis score mbpgi levels hepatitis virus hcv positive patients significantly higher hcv negative patients even fibrosis stage phlf grade developed patients area roc curve auroc mbpgi prediction phlf grade multivariate analysis mbpgi odds ratio confidence interval platelet count resection rate significant factors associated phlf grade auroc phlf index defined factors notably patients hcvinfection predictive ability mbpgi phlf auroc best among preoperative parameters conclusions mbpgi useful predictor phlf especially patients hcv infection
new approach control electro magneto mechanical system proposed paper conventionally systems controlled based maxwell system model via pid control technique displays acceptable performance low frequency region high frequency region position control performance greatly degraded order improve performance newly developed virtual order system modeling technique ssid adopted complex electro magnetomechanical system study technique states unknown system exposed random disturbance unknown intensity identified terms virtual order system model via inverse process certain stochastic analysis typical hybrid system solenoid valve used target electro magneto mechanical system study modeling virtual order system order confirm performance proposed control strategy autotuning pid controller pwm mode utilized simulations based conventional maxwell system model control via bang bang autotuning pid proposed virtual order system model approaches conducted using matlab simulink performance three systems low high frequency bands also compared simulation results reveal control performance virtual order system model much improved compared maxwell system model autotuning pid bang bang controls low high frequency regions error drastically reduced approximately original value
mindfulness meditation simply mindfulness ancient method attention training arguably developed originally buddha practiced buddhists years part spiritual training popularity mindfulness soared recently following adaptation mindfulness based stress management jon kabat zinn mindfulness often compared hypnosis assertions accurate article primer delineates similarities dissimilarities mindfulness hypnosis terms specific facets including putative neuroscientific findings also provides case example illustrates clinical integration two methods
agreement literature time onset progress vertebral column ossification aim present study determine precise sequence ossification neural arches vertebral centra histological radiographic studies performed human foetuses aged weeks found ossification vertebrae commences foetuses aged weeks ossification centres appear first neural arches cervical upper thoracic vertebrae end week present thoracic lumbar neural arches vertebral centra foetus weeks ossification found lower thoracic first lumbar vertebrae end week ossification present lower cervical thoracic lumbar sacral vertebral centra study indicates ossification neural arches proceeds craniocaudal direction whereas vertebral centra progresses lower thoracic vertebrae directions different shapes ossification centres also described
ovarian cancer sixth common cancer among women prognosis favorable diabetes mellitus hypothesized associated higher mortality ovarian cancer patients evidence inconsistent thus aim investigate associated long term cause long term cancer specific mortality ovarian cancer patients synthesizing available epidemiologic evidences used electronic databases pubmed embase web science scopus search eligible articles title abstract screening full text review data extraction quality assessment performed reviewers independently meta analysis studies reporting risk ratio hazard ratio investigated association mortality patients synthesized random effect model subgroup sensitivity analyses performed certain stratification restrictive rules publication bias assessed funnel plots egger test statistical heterogeneity evaluated squared value chi squared test cochrane statistic twelve cohort studies involving outcome measures included overall meta analysis synthesized cause mortality without substantial statistical heterogeneity cochrane synthesized cancer specific mortality substantial heterogeneity cochrane publication bias observed results suggest associated higher cause cancer specific mortality ovarian cancer patients future studies done examine association type ovarian cancer mortality
paper propose novel techniques reduce total cost peak load factories customer point view control energy storage system ess minimize total electricity bill korea commercial industrial kci tariff considers peak load time use tou kci tariff average peak load maximum among average power consumptions measured every min past months determines monthly base cost thus peak load control extremely critical aim leverage ess peak load reduction based load prediction well energy arbitrage exploiting tou however load prediction inevitably uncertainty makes ess operation challenging kci tariff tackle apply robust optimization minimize risk real environment approach significantly reduces peak load total cost compared case consider load uncertainty also consider battery degradation cost validate practical use proposed techniques
part syndrome behavioral phenotype significant impairment expressive communication begins early impairments verbal imitation requesting observed infants syndrome contrast social interaction relative strength replicated intervention procedures using social reinforcement prompting feeley teach infants syndrome imitate sounds engage increasingly sophisticated forms social instrumental requests examined generalization collateral changes intelligibility problem solving infants learned imitate verbalizations make requests showed generalization imitating novel sounds requesting different toys semi structured assessment infants also showed verbal imitation intelligible naive listener improvements problem solving suggesting intervention may broader effects requesting verbal imitation
location based social network lbsn flourishing location check records offer sufficient information resource relative mining among locations visited user attracting relatively visits user serve support mining improvement location based services therefore great significance lies partition visited locations based user visiting frequency aim paper partition locations individual users utilizing classification machine learning categorizing location user makes initial check feature extraction initial check record evaluate contribution three feature categories results show contribution different feature categories varies classification social features appear offer least contribution last final test whole sample comparing results two baselines based majority voting respectively results largely outperform baselines general demonstrating effectiveness classification elsevier rights reserved
virtual blended learning use virtual environments education already delivered utility number cases article presents concept prototype environment used current semester employ new medium programming education universities concept brings gamification aspects well interaction mechanisms social media virtual environment thereby aims reduce large number student dropouts due failing programming modules motivating less capable students alike increased participation practical exercises concluded concept applicable much broader spectrum exercise tutorial settings
large body research documented exposure images thin fashion models contributes women body dissatisfaction present study aimed experimentally investigate impact attractive celebrity peer images women body image participants female undergraduate students randomly assigned view either set celebrity images set equally attractive unknown peer images control set travel images images sourced public instagram profiles results showed exposure celebrity peer images increased negative mood body dissatisfaction relative travel images significant difference celebrity peer images effect mediated state appearance comparison addition celebrity worship moderated increased effect celebrity images body dissatisfaction concluded exposure attractive celebrity peer images detrimental women body image elsevier ltd rights reserved
background giardia intestinalis commonly reported human intestinal parasite united states increased incidence chronic gastrointestinal complaints reported giardiasis outbreaks examined relationship giardiasis diagnosis irritable bowel syndrome ibs diagnosis methods used marketscan commercial insurance database persons least giardiasis diagnosis individually matched age group sex enrollment length months persons without giardiasis diagnosis persons diagnosed ibs date study entry excluded calculated crude incidence rates irs developed cox proportional hazards models results matched cohort included persons giardiasis persons without giardiasis one year incidence ibs higher persons giardiasis person years person years unadjusted hazard ratio confidence interval attenuated slightly adjusting anxiety depression healthcare utilization conclusions large insurance database individuals diagnosed giardiasis likely subsequent ibs diagnosis despite accounting confounders future research risk factors ibs among giardiasis patients pathophysiology postinfectious ibs needed
paper newly developed thermal hydraulics code coupled state art neutronics deterministic code agent arbitrary geometry neutron transport presented coupled system called agent scheme neutronics agent code uniquely combines method characteristics moc function geometrical modeling solve neutron transport nuclear reactors current future designs commonly cross sections prepared using scale code system implementation code agent enables coupled thermal hydraulic neutronics analysis providing average reactor fuel temperatures allows accurate overall power profiling within reactor system affects reactor coolant temperature neutron flux associated reactor parameters two main types lwrs boiling water reactors bwrs pressurized water reactors pwrs bwrs operate lower pressures pwrs results higher void fraction fraction coolant flow vapor versus liquid performances pwrs higher operating pressure may obtained using homogeneous equilibrium mixture hem model assumes slip relation equal one coolant liquid vapor phases account higher void fraction bwr coolant bwrs properties assessed based drift flux model thermal hydraulics drift flux model developed part code address two phase flow associated two phase heat transfer including subcooled nucleation saturated boiling found bwr systems accomplished based drift flux equations steady state conditions permits fast computation times without sacrificing final accuracy code benchmarked reactor simulation code trace single pin assess thermal hydraulics capabilities drift flux model fluid void fraction flow quality pressure saturation temperature mixture temperature along axial height pin drift flux thermal hydraulics module coupled agent using radial heat transfer model taking account heat transfer fuel centerline bulk fluid fuel temperatures calculated code used update cross sections scale code system account thermal feedback reasonable agreements obtained agent trace presented benchmark examples elsevier ltd rights reserved
use levonorgestrel lng taken day coitus women relatively infrequent sex efficacious safe acceptable contraceptive method typical use lng taken pericoitally within sexual intercourse provides contraceptive efficacy pregnancies per women years primary evaluable population pregnancies per evaluable population lng effective emergency contraception following unprotected intercourse users take repeatedly means regular contraception prospective open label single arm multicentre phase iii trial study women infrequent coitus days month woman follow visit months admission pregnancy occurs sooner decided interrupt participation study conducted january november total healthy fertile women aged years risk pregnancy reported sexual intercourse days month recruited four university centres located bangkok thailand campinas brazil singapore szeged hungary use lng pericoitally coitus primary method contraception participants instructed take one tablet every day sex without taking one tablet period maintain paper diary recording date time every coital act ingestion study tablet use contraceptive methods vaginal bleeding patterns anaemia assessed haemoglobin evaluation pregnancy tests performed monthly pregnancies occurring product use assessed ultrasound month final visit months acceptability questions administered women included evaluable population includes eligible women enrolled woman years observation rate confidence interval pregnancies per typical use reflects use study drug main contraceptive method also includes possible use contraceptives admission end study pregnancies per sole use primary evaluable population includes eligible enrolled women years old rate pregnancies per typical use pregnancies per sole use three reported severe adverse events mild adverse events common headache nausea abdominal pelvic pain high recovery rate vaginal bleeding patterns showed slight decrease volume bleeding number bleeding free days increased time one case severe anaemia found final visit method considered acceptable participants would choose use future would recommend others single arm study small sample size without control group designed proof concept study explore feasibility type contraception larger clinical study evaluating pericoital contraception lng feasible data show method would acceptable many women study received partial financial support undp unfpa unicef world bank special programme research development research training human reproduction hrp department reproductive health research rhr world health organization gynuity bill melinda gates foundation bmgf provided financial support project monitoring hra pharma donated lng product initial project manager hrp employed hra pharma distributes lng emergency contraception authors declare conflicts interest study registered anzctr trial actrn october january
hyperlipidemia one major health problem people suffering throughout world also major risk factor chronic heart disease lead death current study designed investigate antihyperlipidemic hepatoprotective effects selenium modified exopolysaccharide lachnum selep high fat induced mice model nitric acid sodium selenite hno naseo method used selenize pure lep nmr results confirmed modification lep selep main structure selep similar original structure native lep group attached position lep oral administration lep selep notably reduced serum liver lipids atherogenic index enhanced activities antioxidant enzymes hyperlipidemic mice aswell improved histopathological status hepatic tissues hence selep showed better effects lep doses selep demonstrated promising lipid lowering liver protecting activities may considered novel compound treat hyperlipidemia also act hepatoprotective agent published elsevier
purpose paper aims present experimental results gasoline fuelled engine operation crankcase scavenged two stroke cycle engine used unmanned air vehicle uav unmanned air system application cross correlate computational fluid dynamic modelling results design methodology approach computational modelling engine system conducted using wave software supported experimental research development via dynamometer testing spark ignition uav engine construct validated computational model exploring range fuel delivery options findings experimental test data computational simulation allowed assessment potential advantages applying direct cylinder fuel injection practical implications ability increase system efficiency offers significant advantages terms maximising limited resources extending mission duration capabilities computational simulation validation via experimental test experience provides means assessment possibilities costly explore experimentally offers added confidence able investigate possibilities development similar future engine designs originality value software code used applied crankcase scavenged two stroke cycle engines provides valuable facility simulation twin cylinder horizontally opposed design offer system optimisation exploration future possibilities
closed form solution upper lower bounds dual bounds slow indentation rigid ball increasing normal load rigid plastic solids presented solutions enlarge theoretical background familiar brinell hardness tests used assessing strength materials add new features new features mainly constructing lower bound solution ball indentation closed form estimation dual bounds prescribed frictional shear along indenter solid contact iii providing dual bounds two different situations material response removed material falling bulk akin indentation brittle like materials removed material piled along indenter face akin indentation ductile like materials dual bound solutions indenting mean ball pressure material cases seem capture properly well material constrain local plastic indentation effect interfacial friction bounds simultaneously despite unavoidable deviation provide much informative results single bound comparisons suggested bounding analysis experiments taken tabor tabor hardness metals oxford clarendon press johnson johnson contact mechanics cambridge cambridge university press new edition others numerical fem solutions mesarovic fleck mesarovic sdj fleck spherical indentation elastic plastic solids proceedings royal society london others self made measurements favorable elsevier ltd rights reserved
since proposal fast learning algorithm deep belief networks deep learning techniques drawn ever increasing research interests inherent capability overcoming drawback traditional algorithms dependent hand designed features deep learning approaches also found suitable big data analysis successful applications computer vision pattern recognition speech recognition natural language processing recommendation systems paper discuss widely used deep learning architectures practical applications date overview provided four deep learning architectures namely autoencoder convolutional neural network deep belief network restricted boltzmann machine different types deep neural networks surveyed recent progresses summarized applications deep learning techniques selected areas speech recognition pattern recognition computer vision highlighted list future research topics finally given clear justifications
important manage precise power flows closed small power networks reliable operations paper describes method managing instantaneous power flows local area power network order provide instantaneous power load power bus without disturbing modules adaptively adjust power flow keep balance instantaneous power tool balancing use power flows based tellegen theorem kirchhoffs voltage law determine network states uniquely
background purpose sensory hyperreactivity shr patients symptoms airways chest induced environmental irritants like scenting products cigarette smoke characterized increased cough reaction inhaled capsaicin compared healthy controls lung function tests normal asthma medications little effect recent published article patients shr found impaired chest mobility increased pain sensitivity purpose study evaluate physiotherapeutic intervention increase chest mobility shr influence patients symptoms reduce capsaicin cough sensitivity methods forty one shr patients initially randomized groups one training one symptom registration controlled training study consisted daily training programme containing simple movements increase flexibility chest breathing exercise relaxation session well symptom registration chest expansion measured measuring tape thoracic abdominal movement light sensors pain sensitivity assessed using pressure algometry standardized capsaicin inhalation threshold provocation evaluated cough sensitivity results twenty seven patients left analyses weeks patients weeks chest mobility upper thoracic respiratory movements improved feeling chest pressure capsaicin cough sensitivity decreased patients also showed significantly lowered pain pressure thresholds measured algometry compared healthy controls conclusion improvement chest mobility physiotherapeutic intervention indicates patients may acquired dysfunctional breathing pattern regular use training programme structural breathing instructions used improve chest mobility chest symptoms capsaicin cough sensitivity patients shr signs dysfunctional breathing copyright john wiley sons ltd
current paper provides overview cultural religious background pakistan current situation mental health pakistan special emphasis cultural adaptation cognitive behaviour therapy cbt pakistan context sufism islamic mindfulness interesting note easy explain concepts cbt therapists clients pakistan process culturally adapt cbt pakistani culture based patience generating evidence group taken responsibility far successful endeavours pertaining research service development described paper
synthesize optically active terbutaline anti asthmatic drug recyclable catalytic asymmetric transfer hydrogenation rcath various chloroketones prepared rcath performed products exhibit moderate high enantioselectivity particular hydrogenation acyl substituted substrates yields chiral secondary alcohols good yield enantioselectivity furthermore terbutaline synthesized one step resulting secondary alcohol without racemization
objective evidence regarding age autism spectrum disorder asd identified essential improving early detection yet many extant studies applied time event analyses account statistical biases arise sampling cross sectional surveys adjusting child age time parental report objective estimate age distributions first identification asd national parent surveys using time event analyses method conducted time event analyses responses identical questions national survey children health national survey children special health care needs results parents surveys reported minority asd cases identified age years one third one half cases identified years surveys majority parents described child asd severity mild parents reported oldest age identification mean years contrast parents described child asd severe reported earlier age identification mean years time event analyses yielded older estimates age identification analyses based raw distributions conclusion two national surveys majority parents children asd reported identification years eligibility early intervention services expires many reported identification asd school age later identification children milder symptoms highlights need early screening sensitive forms asd regardless severity
fast fourier transform fft based digital calibration method bit stage pipeline analog digital converter adc proposed paper capacitor mismatch finite gain operational amplifier opamp overcome proposed calibration method given capacitor mismatch finite opamp gain cause radix stages bit stage pipeline adc become unequal fft processor adopted evaluate actual radixes stages generate new digital output compensate error caused non ideal effects moreover capacitor mismatch finite gain opamp compensated low gain opamp used high performance adc reduce power dissipation small capacitor adopted save space example bit bit stage pipelined adc bit circuit performance implemented tsmc cmos process circuit measurement result reveals signal noise distortion ratio improvement calibration achieved sample rate mhz copyright john wiley sons ltd
green building developed towards direction low energy consumption high efficiency less pollution paper focused analysis design process application ecological energy saving technique gymnasium weifang medical university view discussing green low carbon energy saving design strategy university gymnasium cold area
recent energy policy favored massive introduction renewable energy sources electricity markets greatly impacted performance first electricity price decreased consequence called merit order effect another relevant effect associated intermittent nature renewable energy increased cost ancillary services third important aspect less addressed literature induced change strategic behavior conventional electricity producers principle entry new generators concentrated market would make competitive change strategic behavior incumbents test hypothesis spanish wholesale market find significant change behavior nuclear hydropower coal change observed combined cycle bidding strategies entry renewable generators analysis shows massive entry renewable energy sources made generators behavior competitive short run effect persistent
conventional algorithm perturb observe widely applied due simplicity low cost easy implementation however suffers instabilities rapid changes weather oscillation around maximum power point mpp steady state instabilities occur due incorrect decision taken conventional algorithm first step change duty cycle rapid change radiation reason steady state oscillation continuous perturbation tradeoff step sizes convergence time study presents modified algorithm overcome drawbacks uses constant load technique help conventional algorithm recognising cause power change enable taking right decision first step change duty cycle rapid change weather proposed algorithm simulated using single solar photovoltaic module boost converter validated experimentally implemented within embedded microcontroller experimental setup presents proposed model based design methodology uses measurements data mpp tracking systems design combines hardware loop simulation prototype testing using actual weather measurements simulation experiments show excellent results
paper presents dynamic model superheat solar steam receiver electricity generation receiver mono tube cavity boiler mounted focal point paraboloidal dish concentrator australian national university dynamic model derived physical principles mass energy conservation uses moving boundary formulation coupled switching approach represent outlet flow ranging sub cooled liquid superheated steam method compute outlet mass flow rate three receiver outlet flow conditions included modelling approach results compact state space representation receiver useful development model based control strategies operation receiver concentrator plant model implemented trnsys validated experimental data australian national university dish system elsevier ltd rights reserved
circular rnas circrnas type non coding rna molecules lack terminal cap terminal poly tail large number circrnas identified biological experiments computational methods high throughput sequencing circrna sequence composition determines given circrna exonic intronic retained intronic circrnas abundant stable linear mrnas expression step location specific circrnas mediate transcriptional post transcriptional regulation gene protein expression circrnas regulate cancer development via multiple mechanisms including mirna sponges modulating wnt signaling pathway epithelial mesenchymal transition depth study circrna provide better understanding carcinogenesis assist developing clinical diagnostic therapeutic strategies elsevier rights reserved
purpose study aimed explore underlying action mechanism tou decoction wtd rheumatoid arthritis network pharmacology prediction experimental verification methods chemical compounds human target proteins wtd well related human genes obtained tcm database taiwan pubchem genbank respectively subsequently molecular networks canonical pathways presumably involved treatment wtd generated ingenuity pathway analysis ipa software furthermore experimental validation carried mip beta induced cell model collagen induced arthritis cia rat model results ccr signaling pathway macrophages shown top one shared signaling pathway associated cell immune response cytokine signaling addition protein kinase pkc delta pathway treated target proteins wtd vitro experiments indicated wtd inhibited mip beta induced production tnf alpha mip alpha rantes well phosphorylation ccr pkc delta cells wtd treatment maintained inhibitory effects production tnf alpha rantes mip beta induced cells ccr knockdown vivo experiments demonstrated wtd ameliorated symptoms cia rats decreased levels beta tnf alpha mip alpha mip rantes serum cia rats well mrna levels mip alpha mip rantes ankle joints cia rats furthermore wtd also lowered phosphorylation levels ccr pkc delta ankle joints macrophages ankle joints cia rats conclusion demonstrated research wtd played role inhibiting inflammatory response closely connected modulation effect wtd ccr signaling pathway macrophages
article describes efficient methods visualize results finite element analysis implementation methods post processing results work based premise computer memory performance limited amount data processed complex finite element analysis enormous therefore kind simplification approximation resulting data used multigrid method inspiration research work development post processor stored data finite element analysis discrete values paper deals several ways replacing continuous functions suitable representation computer graphics different approximation functions used finite element method special attention devoted approximation errors difference functions finite element mesh decomposed sub domains respect approximation errors ways creating mesh hierarchy described details also possibilities nodal value interpolations simplified mesh discussed text besides approximation data space also approximation time used pseudo code approximation algorithm key parts shown various types approximation functions investigated reach lowest approximation error highest compression factor results summarized article elsevier ltd rights reserved
aims study aimed develop test feasibility acceptability initial effectiveness three session psychosocial group intervention reduce hepatitis risk behaviours increase hepatitis transmission knowledge among women inject drugs five european cities towns methods uncontrolled field effectiveness study psychosocial group intervention hepatitis virus hcv transmission knowledge sexual drug risk behaviours depressive symptoms assessed baseline one month post intervention intention treat analyses conducted findings one month post intervention significant increase reported hcv transmission knowledge number new unused needles syringes used inject significant reductions sharing spoons containers mixing used someone else sharing filters cookers spoons water someone hepatitis positive use alcohol swabs following injection conclusions intervention showed promising results reducing hepatitis injecting risk behaviours increasing hepatitis transmission knowledge among women inject drugs preliminary findings suggest feasible deliver intervention drug treatment settings intervention acceptable participants staff
objectiveneurosurgical interventions deep brain stimulation surgery globus pallidus internus gpi play important role treatment medically refractory parkinson disease require high targeting accuracy variability laterality gpi across patients well characterized aim report identify factors may contribute differences position motor region gpi materials methodsthe charts operative reports patients following deep brain stimulation surgery males aged years representing gpi retrospectively reviewed data extracted subject include age gender anterior posterior commissures distance third ventricular width multiple linear regression stepwise regression relative importance regressors analysis performed assess predictive ability variables gpi laterality resultsmultiple linear regression target third ventricular width gender distance age significant normalized linear regression coefficients respectively third ventricular width gender distance age account value respectively effect size calculation significant change gpi laterality per ventricular width per distance per year age increase male gender conclusionthis variability highlights limitations indirect targeting alone argues continued use mri well intraoperative physiological testing account factors contribute patient specific variability gpi localization
schizothorax prenanti prenanti one important endemic commercial fish china mainly distributing upstream river yangtze tributaries wild population facing serious challenges germplasm degeneration due overfishing water pollution construction hydropower stations therefore urgent develop genetic resource prenanti protect wild population study used illumina hiseq sequencing develop single nucleotide polymorphism snp markers prenanti unigenes functional annotation putative snps identified among snps immune related genes randomly selected loci exhibited significant polymorphisms genotyping sequenom massarray far best knowledge first report snp markers development prenanti based illumina rna sequencing snp markers useful population conversation also construction genetic linkage map economic performance improvement prenanti
background three dimensional acetabular orientation fundamental topic orthopedic surgery computed tomography allows measurement native acetabular orientation substantial radiation dose eos imaging system developed perform kind evaluation validated indication specific attention acetabulum therefore performed prospective study using eos assess reproducibility acetabulum orientation measures normative asymptomatic acetabular morphology standing position according side gender relationship acetabular anteversion pelvic incidence hypothesis low doseeos imaging system reproducible method measuring acetabular orientation standing position patients methods previous prospective study spine sagittal balance asymptomatic volunteers examined whole body eos biplanar ray appropriate images pelvic acetabular analysis equal sex ratio female male eos images reviewed using stereos software allowing automatic measurement acetabular parameters anteversion inclination pelvic parameters pelvic incidence pelvic tilt sacral slope anatomical anterior pelvic plane app functional reference plane patient vertical plane pvp results intra inter observer analysis showed good agreement icc bland altman plot distributions good acetabular anatomical anteversion inclination relative app aaapp aiapp respectively significantly greater women men effect side right aaa women degrees degrees men degrees degrees right aiapp women degrees men degrees degrees left aaapp women degrees degrees men degrees degrees left aiapp women degrees degrees men degrees degrees differences men women observed measurements related pvp pelvic incidence subgroup degrees correlated significantly functional acetabular orientation standing position pvp functional anteversion decreased relative app anteversion incidence degrees discussion use stereos software prototype version reconstruction native acetabulum standard eos ray shown reliable reproducible method innovative method enabled reference values acetabular orientation standing position measured first time results reinforced concept hip spine relationships involved low radiation dose elsevier masson sas rights reserved
background frequency severity injury beach soccer unknown purpose estimate incidence rates characteristics risk factors injuries associated beach soccer study design cohort study level evidence methods sports physician examined recorded injuries incurred japanese national beach soccer championships posttournament follow made injuries match exposure player recorded video review examine individual risk factors results total injuries recorded matches overall injury rate time loss injury rate per player hours foot toe frequently injured area followed lower leg thigh ankle injury frequent injury type contusions followed lacerations abrasions sprains ligament injuries injuries resulted days time loss adjusting age previous history severe injury longer experience beach soccer significantly associated injury risk conclusion time loss injury rate study comparable rates reported matches soccer futsal tournaments however greater incidence foot toe injury lacerations abrasions well lower incidence ankle injury distinguished beach soccer soccer futsal possibly related specific playing conditions barefoot sand surface
international contest strongly influenced historiography demographic policies romania bulgaria former yugoslavia national regimes justified severe birth control policies necessary productive system healthcare time western scholars considered expression attempt extend widespread control aspects society peculiarity demographic policy yugoslavia far liberal romania bulgaria considered proof heterodoxy regime end cold war dramatic events nineties former yugoslavia fostered development new domestic historiography actively supported policies population growth promoted region particularly serbia contrary exception anthropological sociological works interest declined concerns many states former soviet bloc
piezoelectric actuators used successfully enable locomotion micro robot micro air vehicle flapping wings however use piezoelectric actuators presents major challenge power electronic design input capacitance devices makes use delicate instantaneous power may much greater average effective power due challenge conventional drive circuits especially inductor become bulky inefficient low mass applications work describes converter suitable drive kind actuators low inductor moreover converter provides recovery energy stored actuator capacitance back primary power supply actuator supply proposed converter structure capable producing square unipolar voltage design auxiliary shunt circuits connected actuator signal flow graph modeling analysis design scheme presented experimental validations demonstrated effectiveness proposed technique recovery energy
two experiments conducted investigate effects coaction saccadic manual responses participants performed experiments either solitary condition group coactors performed tasks time experiment participants completed pro antisaccade task required make saccades towards prosaccades away antisaccades peripheral visual stimulus experiment participants performed visual discrimination task required making saccade towards peripheral stimulus making manual response reaction stimulus orientation results showed performance stimulus driven responses independent social context volitionally controlled responses delayed presence coactors findings line studies assessing effect attentional load saccadic control dual task paradigms particular antisaccades prosaccades influenced type social context additionally number coactors present group moderating effect saccadic manual responses results support attentional view social influences
article proposes automatic image processing method effective diagnostic tool detect grade severity diabetic retinopathy computer vision based algorithm imitates logic medical sense used ophthalmologist detecting abnormality location image grading severity disease detection based finding abnormalities exudates red lesions grading based location abnormalities image referred distance macula accordingly entire image divided regions occurrence abnormalities regions indicates severity disease methodology stresses two major factors accuracy results computation time found design parameters nicely achieved proposed method experimental results indicate overall accuracy achieved proposed method also significantly reduce computational complexity region based approach
vegetarian diet thought health benefits including reductions type diabetes hypertension obesity evidence date suggests vegetarians tend lower mortality rates compared non vegetarians studies population based healthy lifestyle factors may confounded apparent protective effects aim study evaluate association categories vegetarian diet including complete semi pesco vegetarian cause mortality large population based australian cohort study cohort study men women aged years new south wales nsw australia vegetarian diet status assessed baseline questionnaire participants categorized complete vegetarians semi vegetarians eat meat week pesco vegetarians regular meat eaters cause mortality determined linked registry data mid cox proportional hazards models quantified association vegetarian diet cause mortality adjusting range potential confounding factors among participants mean age years men deaths mean years follow following extensive adjustment potential confounding factors significant difference cause mortality vegetarians versus non vegetarians also significant difference mortality risk pesco vegetarians semi vegetarians versus regular meat eaters found evidence following vegetarian diet semi vegetarian diet pesco vegetarian diet independent protective effect cause mortality elsevier inc rights reserved
digit ratio sexually dimorphic trait men relatively shorter index fingers compared ring fingers women evidence suggests masculine ratios influenced higher prenatal testosterone levels testosterone aggression related accordingly evidence suggests male related physical aggression bailey hurd female related reactive aggression benderlioglu nelson shown violent media impact aggressive behavior predict relationship aggression stronger exposed aggressive non aggressive music video accordingly show aggression measured two different measures related exposure aggressive video suggest future research focus plausible interactions context cues rather linear relations elsevier ltd rights reserved
relying quantitative survey semi structured interviews conducted explore british nationals romanian turkish migrants attitudes tolerance factors influencing current socio political context quantitative data reveal role younger age diverse networks higher education attachment city region supranational identifications open attitudes towards diversity qualitative findings illustrate diverse three groups attitudes tolerance affected position status british attitudes show tolerance reflect diverse forms acceptance ethnic cultural differences also draw lines terms civic values opposing contribute society versus live parasites turks favour diversity expectation receiving civic rights facing less prejudice romanians tend ambiguous relation diversity given position stigmatised migrants analysis reveal inclusive exclusive people sub supra national identities frame attitudes tolerance
study videotaped two min free play interactions coded speech acts sas peer talk preschoolers asd typical interacting friend versus non friend partners groups matched maternal education verbal nonverbal compared sas group asd typical partner friendship status friend non friend partner disability status main results yielded higher amount diversity sas typical asd group mainly assertive acts organizational devices object dubbing pretend play yet categories among others showed better performance friends versus non friends overall nuanced perception pragmatic deficit asd adopted highlighting friendship important context children development sas
part paper introduce useful analysis leads simple signal flow graph sfg captures fet circuit action completely across wide range design parameters part focuses analysis single path fet circuit signal transfer characteristics gives guidelines sample hold passive sampling mixer designs part extends analysis multi path fet circuit configurations complex qpassive mixer common applications noise driving point impedance analyses carried provide valuable insights practical designs
currently matlab simulink used simulation tool dynamic systems modeling large dynamic systems wind energy conversion systems implies wide range blocks wind model turbine model generator model power electronics model transformer grid model blocks implement differential equations models requires different simulation steps electrical generator power converter smallest simulation step therefore blocks determine simulation speed paper present important aspects regarding different implementations induction machine model increase simulation speed increased application simulation wind turbine
research biosocial correlates antisocial behavior revealed importance integrating sociological findings evidence flowing genetics neuroscience present study represents step toward integration offering depth overview neurocriminology study brain affects antisocial behavior consider role brain antisocial criminal behavior well drug use abuse highlight various regions systems brain identified targets intervention areas need study knowledge equips foundation think translationally promote mental health adaptive behavior well among drug using criminal offenders
previous paper phys essays introduced relativistic electromagnetic force law theory relativity alternative lorentz force law special relativity demonstrated existing experimental evidence convincingly distinguish two force laws addition proposed uniform circular motion experimental test distinguish two force laws present paper first emphasize important distinctions two force laws next propose linear motion experimental test two force laws complementary previously proposed test experimental test proposed less expensive practical carry previously proposed test
aimed problem cold resulted sleeping fidget infants paper explored mechanism sleeping fidget presented relational model sleeping fidget temperature humidity changes authors developed data acquisition system temperature humidity based digital sensor acquired lots data temperature humidity corresponding fidget degree designed neural networks model construct analyzing relation among three kinds data basis model trained experimental data based matlab toolbox model verification shows sleeping fidget model effectively implement sleeping fidget monitoring
objective determine survival success rate cad cam fabricated monolithic lithium disilicate crowns supported zirconia oral implants years material methods twenty four patients need single tooth replacement received zirconia implant finally restored single crowns scs ground precrystallized lithium disilicate blanks restorations adhesively cemented evaluated using modified united states public health service usphs criteria case clinically relevant defects could repaired acceptable level scs regarded surviving restorations minor chippings small area roughness empty set slightly soundable marginal gaps minimal overcontours tolerable color deviations vitashade regarded success kaplan meier method log rank tests used success survival analyses calculation potential group differences gender location jaw additionally several patient reported outcome measures proms evaluated results twenty three patients seen years implant placement replaced resulting survival chippings observed one showed major occlusal roughness kaplan meier success rate mean observation period months group differences could calculated compared pre treatment surveys proms showed permanently improved perception function esthetics sense speech conclusion monolithic lithium disilicate scs supported zirconia implants showed promising survival success rates observation period years remains seen whether observation period confirms positive results
jill lepore secret history wonder woman reads like historical detective story story creation wonder woman really three intersecting stories origins feminism birth control movement unusual life wonder woman creator william moulton marston lepore teaches history harvard staff writer new yorker reaches beyond history popular culture reveal treasure chest secrets wonder woman creator uncommon historically significant family lepore wise lucid deeply researched book rewarding blend cultural history psychology sociology told zest novelist command narrative
current study examines effect status information neural substrates person perception event related fmri experiment participants presented photographs faces preceded information denoting either low high financial status earns earns low high moral status tobacco executive cancer research participants asked form impression targets instructed explicitly evaluate social status building previous brain imaging investigations regions interest analyses performed brain regions expected support either cognitive intraparietal sulcus emotional ventromedial prefrontal cortex components social status perception activation intraparietal sulcus found sensitive financial status individuals activation ventromedial prefrontal cortex sensitive moral status individuals implications results towards uncovering neural substrates status perception broadly extended network brain regions involved person perception discussed elsevier ltd rights reserved
focusing mechanism important part zoom lens production manufacturing engineering order meet reading detection anti counterfeiting label laser anti counterfeit platform paper presents principle method using linear driving mode focusing introduces focusing mechanism consists stepping motor linear guide rail rail screw gear rack dsp controller contrast test verifies location precision ball screw type focusing mechanism similar higher design requirements suitable use laser anti counterfeit authentication system production manufacturing engineering
schizotypy term refers continuum personality characteristics emerging mental states ranging organized normal unorganized disordered latter tending include individuals high schizotypal scores well diagnosed schizotypal personality disorder evidence psychophysiological studies found relative weakness inhibitory functioning including prepulse inhibition ppi sensory gating antisaccade eye movement aem schizotypy schizophrenia schizotypy schizophrenia spectrum understanding nature sensory motor inhibitory weakness associated schizotypy optimize prevention intervention schizotypy schizophrenia populations review aims examining deficits sensory gating saccade control prepulse inhibition schizotypy examining relationship three measures schizotypal symptoms traits examining effect nicotine three measures examining relevant brain regions three measures searched multiple databases medline pubmed psychinfo google scholar using combinations keywords schizotypy schizotypal personality disorder prepulse inhibition sensory gating antisaccade articles published english since found three measures ppi aem associated major schizotypal symptoms suggesting three measures could used predict disease etiology prognosis secondly three measures modulated nicotine administration certain level providing potential tool study role nicotine cognition symptom improvement schizotypy thirdly brain imaging studies localized activity brain regions associated sensory gating saccade control prepulse inhibition narrowing search brain regions target treatment prevention schizotypy overall three measures suggested valuable tool study inhibitory deficits schizotypy maybe used tool prevention treatment schizotypy well published elsevier
vlsi technology adopted widely nowadays biomedical applications improve healthcare diagnosis monitoring cure analog devices converters biomedical applications modest precision need energy efficient order operate decades cntfet future alternative used various high performance low power devices paper presented low power cntfet based two stage amp biomedical converters sample hold circuit also implemented using cntfet based amp used biomedical adcs simulation results cntet based circuits compared mosfet circuits results indicate improvement power consumption proposed circuit simulations carried hspice concluded cntfet based circuits prime choice low power applications
paper new control structure presented extract maximum power wind regime novel approach discrete time higher order sliding mode controller designed observer construct reference value extractable power based condition operates possible tracking optimal tip speed ratio manipulating voltages rotor doubly fed induction generator dfig configuration presented structure improves performance abrupt changes wind speed used type optimum active power tracking algorithms simulations show significant improvement performance nonlinear discrete time backstepping controller utilizing technique
work designed visitor counting machine vcm terms power efficient circuit using family three different standards lvttl mobile ddr hsul three different standards compared basis clock power logic power signal power ios leakage power total power consumption search power efficient one order find efficient circuitry collected data power consumption three standards compare analysed circuitry different frequencies ghz ghz ghz ghz experiment power saving ghz used place ghz using mobile ddr also concluded replace lvttl hsul ghz frequency power saving achieved design energy efficient visitor counting machine using verilog hdl xilinx ise simulator artix fpga
data exist adverse drug reactions adr elderly people group pharmacotherapy represents challenge regard comorbidities drug interactions compliance aim article highlight characteristics adr elderly patients addition literature review present first data leipzig research center civilization diseases life total subjects aged years randomly included population based age sex standardized investigation inhabitants leipzig germany special emphasis placed allergies including questions regard adr subjects data allergies available subjects female gender comorbidities use multiple drugs significantly associated increased risk adr women also reported adr significantly frequently men subjects reported suffering form adr result medications reaction occurred within previous months less life patients adr possession document giving details adr occurrence adr significantly contributes morbidity elderly patients prevention adr knowledge patient related factors underlying diseases drug characteristics drug interactions necessary
physical examination swelling first step making diagnosis many times see patient spherical swelling usually cyst interpretation physical signs based sound principles physics present paper explain physical characteristics swelling cyst using principles fluid mechanics
robot software combines challenges general purpose real time software requiring complex logic bounded resource use physical safety particularly dynamic systems humanoid robots depends correct software general purpose computation converged unix like operating systems standardized posix portable operating system interface devices cellular phones supercomputers modular multi process design typical posix applications effective building complex reliable software absent posix however interproccess communication mechanism prioritizes newer data typically desired control physical systems address need ach communication library provides suitable semantics performance real time robot control although initially designed humanoid robots ach broader applicability complex mechatronic devices humanoid otherwise require real time coupling sensors control planning actuation initial user space implementation ach limited ability receive data multiple sources remove limitation implementing ach linux kernel module enabling ach high performance latest message favored semantics within conventional posix communication pipelines discuss posix interfaces design principles apply robot software present case study using ach kernel module communication baxter robot
research efficacy yoga improving mental emotional physical behavioral health characteristics school settings recent growing field inquiry systematic review research school based yoga interventions published peer reviewed journals offers bibliometric analysis identified publications studies publications conducted primarily united states india since majority studies conducted onward half publications studies elementary schools conducted within school curriculum also implemented formal school based yoga program high degree variability yoga intervention characteristics including overall duration number duration sessions published research trials preliminary nature numerous study design limitations including limited sample sizes median range relatively weak research designs randomized controlled trials uncontrolled trials would expected infant research field nevertheless publications suggest yoga school setting viable potentially efficacious strategy improving child adolescent health therefore worthy continued research
flow vectoring pair synthetic jets suitable modification global flow characteristics practical applications active flow control adaptive heat convection interaction pair synthetic jets separation distance stroke length reynolds number investigated numerically using computational fluid dynamics cfd experimentally using particle image velocimetry piv achieve realistic calculation flow induced synthetic jets full unsteady rans simulation performed internal flow two cavities well external jet flow using dynamic mesh technique results intricate flow vectoring phenomenon show reasonable quantitative agreement piv measurements maximum deviation piv measurements stream wise centreline velocity effect phase difference pair jets vectoring merged jet investigated delta phi degrees degrees degrees merged jet vectored direction cavity leading phase similar trend shown experimental numerical results instantaneous time averaged vortical structures leads better physical understanding fluid mechanics adjacent synthetic jets enhance theoretical basis needed promote practical application elsevier ltd rights reserved
objective translate evaluate psychometric properties arabic language version depression anxiety stress scales dass method items translated back translated refined tested australian immigrant sample results confirmatory factor analysis showed arabic dass discriminates depression anxiety stress lesser degree english dass factor loadings items comparable english dass indicating items appropriately translated adapted analysis exploratory items suggested arabic speaking mental health professionals failed reveal new items psychometrically adequate theoretically coherent analysis bilingual sample indicated english norms appropriate arabic dass conclusion results support universality depression anxiety stress across cultures provide initial support psychometric properties arabic dass
test well functioning housing system wellbeing occupants may therefore seem encouraging jurisdictions dominated mortgage backed home ownership owner occupiers traditionally report better physical mental health renters however era financial crisis wellbeing edges ownership came strain using data two national panel surveys survey household income labour dynamics australia british household panel survey successor understanding society track wellbeing households sustained one spells home ownership decade estimate log log regression models mental wellbeing country documenting appropriate range controls effects tenure transitions ownership renting associated financial transactions anchored mortgage debt find wellbeing premium associated outright ownership debteffect among mortgagors wellbeing deficit among drop owner occupation partial recovery exit enduring leavers especially wellbeing cost equity borrowing cross national differences institutional explanation similarities relating character regulation mortgage markets striking
given high rates trauma exposure south africa mental health practitioners often need deliver interventions trauma survivors local trauma intervention studies extensive international evidence base provides rich resource draw article reviews evidence based treatments posttraumatic stress disorder complex posttraumatic stress disorder current weight evidence supports use trauma focused cognitive behavioural therapy approaches treatment posttraumatic stress disorder use multimodal phase based interventions treat complex posttraumatic stress disorder also long standing though less extensive evidence base psychodynamic therapy treatment conditions well number emerging treatment approaches require study limitations transferring approaches south african context current evidence base provides valuable guidelines local practitioners seeking develop competencies treating posttraumatic stress disorder complex trauma based presentations
paper describe mechanism bonding coated wires alloy casting medium socket terminations prefabricated parallel wire strands ppwss used main cable suspension bridge single wire pullout tests conducted using various design conditions investigate effects embedded length cavity angle cleanliness wire casting temperature hot casting socket terminations full scale cable pullout tests also conducted clarify bonding mechanism real cable sockets test results revealed bonding resistance socket termination considered study comparable traditional galvanized wire casting sockets confirmed new combination could effectively used main cable suspension bridge elsevier ltd rights reserved
recent advancements wireless sensor network wsn basis many advanced technologies like lots constraint full wsn support operating systems like tinyos contiki mantis sos nanork etc popular highly documented among many tinyos tinyos limitations terms cpu scheduling realtime applications support etc nonpreemptive first come first serve policy tinyos emergency jobs get quick responses node throughput decreases eradicate major limitation tinyos many researchers proposed better scheduling mechanisms first fold paper aims briefing main additional features tinyos second fold different scheduling techniques proposed different authors reviewed
authors often convey meaning referring imitating prior works literature process creates complex networks literary relationships intertextuality contributes cultural evolution paper use techniques stylometry machine learning address subjective literary critical questions latin literature corpus marked extraordinary concentration intertextuality work term quantitative criticism focuses case studies involving two influential roman authors playwright seneca historian livy find four plays related distinct seneca main writings differentiated rest corpus subtle important stylistic features offer literary interpretations significance anomalies providing quantitative data support hypotheses use unusual formal features interplay sound meaning second part paper describes machine learning approach identification analysis citational material livy loosely appropriated earlier sources extend approach map stylistic topography latin prose identifying writings caesar near contemporary livy inflection point development latin prose style total results reflect integration computational humanistic methods investigate diverse range literary questions
emulation modelling successfully applied many environmental applications reduce large computationally demanding process based models low order surrogates used place original model problems involving hundreds thousands model simulations typical examples include optimal planning management data assimilation sensitivity analysis study describe identification dynamic emulator hydrodynamic reservoir model subsequent use within real time control framework dam operation particular adopt novel data driven approach combines many advantages data driven modelling representing complex non linear relationships preserves state space representation typical process based models particularly effective designing controller approach demonstrated marina reservoir singapore recently reclaimed sea transformed freshwater storage constructing barrage dynamic emulator salinity evolution control point near dam identified used combination model predictive control design real time operation barrage results show salinity levels due saline intrusion groundwater seepage dropped drinking water standards embedding emulator real time controller
background major depressive disorder mdd often resistant treatment usual approaches patients mdd shown hypofunction frontotemporal cortex verbal fluency test vft related near infrared spectroscopy nirs methods examined whether reactions drug treatment treatment naive patients mdd could predicted nirs outcomes initial investigation subjects underwent psychological testing determine levels anxiety depression vft used examine functioning frontotemporal lobes administered selective serotonin reuptake inhibitors ssris weeks subjects included patients mdd response ssris response group response non response group age sex education years matched healthy controls results found frontotemporal region hemodynamic responses significantly smaller patients response non response groups treatment also found medial frontal region hemodynamic responses significantly larger patients response groups patients non response group treatment patients mdd scored significantly higher anxiety depressive states several measures response non response groups also higher scores future denial threat prediction self denial past denial interpersonal threat sections anxiety cognition scale dacs according stepwise regression analysis one variable determined independent predictors response confusion post poms limitations number patients healthy controls relatively small increase number participants future studies nirs reduced spatial resolution confuses identification measurement position using nirs alone conclusion cognitive vulnerabilities associated predictors ssri treatment response different hemodynamic activities frontotemporal cortex predict response ssri treatment mdd
paper concerned problem model reduction neutral type control system given stable neutral type control system attention focused construction reduced order model approximates original system well robust performance also translated linear lower dimensional system sufficient condition proposed asymptotic stability error performance error system model reduction problem solved using projection approach casts model reduction subject linear matrix inequality constraints employing cone complementary linearization algorithm moreover extending results model reduction special structures obtained neutral type model numerical simulation example provided demonstrate effectiveness applicability proposed controller design approach
background high levels stress identified medical students increasingly health profession student population groups stress affect psychological well interfere learning clinical performance clear argument universities include health professional student well outcome core curriculum mindfulness training potential construct manage stress enhance academic success objectives aims systematic review assess effectiveness mindfulness training medical health professional student population groups compare effectiveness different mindfulness based programs data sources literature search completed using cochrane library medline cinahl embase psychinfo eric proquest electronic databases inception june randomized non randomized controlled trials included potential articles met inclusion criteria study selection participants interventions studies focused medical nursing social work psychology medical plus health students interventions based mindfulness data extraction studies included participants meta analysis performed evaluating effect mindfulness training mindfulness anxiety depression stress mood self efficacy empathy effect mindfulness academic performance discussed data synthesis conclusions mindfulness based interventions decrease stress anxiety depression improve mindfulness mood self efficacy empathy health profession students due range presentation options mindfulness training relatively easily adapted integrated health professional training programs
work novel application ant lion optimizer alo presented adaptive identification infinite impulse response iir filters alo nature inspired population based gradient free meta heuristic algorithm works based interaction antlions ants uses roulette wheel selection fitter antlions catching ants iterative process optimization performance best antlion iteration compared elite antlion ensured optimum solution demonstrate filter modeling efficacy alo four iir benchmark systems different orders considered equal reduced ordered identifications modeling performance assessed using mean square error mse actual identified model performances mean square deviation msd actual identified iir filter coefficients rate convergence alo outperformed two recent meta heuristic algorithms cuckoo search algorithm csa gravitational search algorithm gsa recently used filter modeling assess robustness obtained solutions fifty independent identification trials conducted mse msd values analyzed statistically standard deviations means addition statistical test mse values alo offered least standard deviations indicating robust solutions test higher positive values indicated significant superiority alo csa gsa iir filter modeling
radar imaging satellite mission terrasar requires precisely determined satellite orbits validating geodetic remote sensing techniques since achieved quality operationally derived reduced dynamic orbit solutions limits capabilities synthetic aperture radar sar validation effort made improve estimated orbit solutions paper discusses benefits refined dynamical models orbit accuracy well estimated empirical accelerations compares different dynamic models orbit determination modeling aspects discussed paper include use macro model drag radiation pressure computation use high quality atmospheric density wind models well benefit high fidelity gravity ocean tide models sun synchronous dusk dawn orbit geometry terrasar results particular high correlation solar radiation pressure modeling estimated normal direction positions furthermore mission offers unique suite independent sensors orbit validation several parameters serve quality indicators estimated satellite orbit solutions include magnitude estimated empirical accelerations satellite laser ranging slr residuals slr based orbit corrections moreover radargrammetric distance measurements sar instrument selected assessing quality orbit solutions compared slr analysis use high fidelity satellite dynamics models approach shown clearly improve orbit quality compared simplified models loosely constrained empirical accelerations estimated empirical accelerations substantially reduced tangential direction working refined dynamical models likewise slr residuals reduced slr derived normal direction position corrections reduced obtained period radar range bias reduced updated orbit solutions coincides reduced standard deviation slr residuals improvements mainly driven satellite macro model purpose solar radiation pressure modeling improved atmospheric density models use state art gravity field models
selection optimal parameters design electric motor multivariable multimodal optimization problem requires considerable amount computational calculation time solve type problem paper proposes novel multimodal optimization algorithm assisted surrogate model using newly developed compressed sensing theory effectiveness confirmed comparing optimization results test functions results conventional optimization methods results show proposed method rapid accurate convergence characteristics conventional approaches verify feasibility application electric motors wheel motor designed using proposed algorithm
exposure data available children europe worldwide aim study assess exposure cosmetic products used children aged years using recent consumption data generated french population exposure assessed using probabilistic method products including cleanser skin care fragrance solar bottom products exposure data obtained study children aged years higher values fixed sccs common products liquid shampoo face moisturizer cream toothpaste shower gel body moisturizer cream exposure assessed first time many products sunscreens eau toilette massage products new french exposure values useful safety assessors safety agencies elsevier ltd rights reserved
study hyperspectral reflectance hysr data derived handheld spectroradiometer used assess water status three grapevine cultivars two sub regions douro wine region two consecutive years large set potential predictors derived hysr data considered modelling predicting predawn leaf water potential psi different statistical machine learning techniques three hysr vegetation indices selected final predictors computation models season time trend removed data using time predictor vegetation indices selected normalized reflectance index wavelengths nri water index wavelengths index associated rate reflectance increase wavelengths vegetation indices covered green red edge near infrared domains electromagnetic spectrum large set state art analysis statistical machine learning modelling techniques tested predictive modelling techniques based generalized boosted model gbm bagged multivariate adaptive regression splines mars generalized additive model gam bayesian regularized neural networks brnn showed best performance predicting psi average determination coefficient ranging rmse varying mpa cultivar touriga nacional used training models cultivars touriga franca tinta barroca testing independent validation models performance good particularly gbm rmse mpa additionally comparison psi observed predicted showed equitable dispersion data various cultivars results achieved show good potential predictive models based vegetation indices support irrigation scheduling vineyard elsevier rights reserved
background many japanese infants food protein induced enterocolitis syndrome fpies show eosinophilia thought characteristic food protein induced proctocolitis fpip methods elucidate characteristics eosinophilia japanese fpies patients infants non ige mediated gastrointestinal food allergy due cow milk enrolled classified fpies fpip results percentage peripheral blood eosinophils increased fpies patients median comparable fpip patients among fpies patients highest patients vomiting bloody stool diarrhea simultaneously lowest patients diarrhea alone showed significant positive correlation incidence vomiting cramer bloody stool cramer significant difference found early days fpies median production peripheral blood cells stimulated cow milk protein early onset fpies significantly higher late onset fpies showed significant positive correlation conclusions study demonstrated two types eosinophilia japanese fpies infants conspicuous mild eosinophilia early late onset fpies patients respectively conspicuous eosinophilia early onset fpies suggested caused abnormally high production copyright japanese society allergology production hosting elsevier
plug hybrid electric vehicle phev independent internal combustion engine acts auxiliary unit mostly electric drive system main flux switching permanent magnet machine fspmm studied terms structure operation principle analyzed achieve higher torque corresponding high power density lower torque ripple fspmm slots poles slots poles according investigations optimized based objective functions moreover analyzes several typical performance curves cogging torque flux linkage back emf finally torque corresponding power efficiency rotor mechanical strength analysis optimized designed obtained results indicate fspmm viable candidate phev also good mechanical robustness strong flux weakening ability
attacks network caused variety serious problems intrusion detection network still immature technology important network security timely detect anomalies rapidly response many intrusion detection methods proposed simple sophisticated techniques literature among context based intrusion detection cbid algorithm excellent however cbid method relying personal experience clear way determine context window size paper propose novel scheme solve problem using chaos theory select parameter intrusion detection algorithm evaluate scheme using traffic traces real network namely caida dataset experiment results show proposed method higher true positive lower miss rate contrast cbid
introduction several contraceptive methods prevent pregnancy reversible well nonreversible ones sexual satisfaction couples affected many types contraceptives used aim aim study evaluate prospectively effect vasectomy sexual life satisfaction couples methods seventy six couples took part evaluation filled respective questionnaires vasectomy questionnaires evaluated statistically differences respective sexual domain scores main outcome measures standardized questionnaires used international index erectile function iief well postoperative pain score completed men female sexual function index fsfi completed female partner statistical analysis square test used results average age couples chose vasectomy procedure years women years men contraception method frequently used prior vasectomy birth control pill male partner iief showed significant change respective domains couples males female partners would recommend vasectomy postoperative pain score scale postoperative complications reported best improvement sexual function noticed female partners fsfi showed significant improvement domains desire arousal orgasm lubrication satisfaction conclusion first report best knowledge showed positive impact vasectomy sexual satisfaction couples vasectomy safe operation minimal complication rates mohamad ali shamloul ramsauer bella scrinzi treu jungwirth effect vasectomy sexual life couples sex med
objective evidence suggest one ability delay gratification associated lower body mass index bmi slower overall weight gain less known role broader set self regulatory skills including attention focusing inhibitory control impulsivity might play fostering healthy weight also better overall health health related behaviors sleep method participants national institute child health human development study early child care youth development followed birth age beginning self regulation assessed children years old whereas health related outcomes assessed regularly toddlerhood adolescence structural equation modeling used test direct associations self regulation either physical health sleep childhood adolescence results findings suggest long term benefits self regulation indexed multiple dimensions children health related outcomes children better self regulatory skills demonstrated smaller increases standardized bmi scores maintained greater mother reported health across childhood adolescence furthermore better self regulation predicted fewer sleep problems longer sleep duration children conclusions early self regulation marked numerous skills appears long term benefits children health related outcomes findings provide evidence targeting childhood self regulatory skills improvement may help reduce poor health related outcomes later life offer important insight potential avenues intervention
previous research documented preservice teachers psts struggle understanding fraction concepts operations misconceptions often stem understanding referent whole study expands research psts understanding wholes investigating pictorial strategies psts constructed multistep fraction task multiplicative context results show many psts able construct valid pictorial strategies strategies widely diverse respect made sense unknown referent whole fraction multiple steps represented wholes drawings order multiple steps type model used area set based wide range pictorial strategies discuss potential benefits psts construction representations word problem developing problem solving skills elsevier inc rights reserved
material flow analysis essential engineering task effective production requires large amount information related products processes resources plants due lack systematic framework supporting system engineers related manufacturing information resources many simulation engineers actually wasted time cost redundant tasks simulation driven modeling simulation system plm suggested implemented paper purpose data structure defined simulation model generation middleware application developed based object oriented model finally concurrent material flow analysis system developed applied area flow analysis case study developed methodology systems driven modeling simulation practically applied automotive press shops based results proposed methodology systems paper useful terms reducing time cost material flow analysis via simulations also possible perform effective engineering tasks simulation material flow analysis via integrated environment relevant data simulation extracted plm system automatically data compatible actual planned shop floor lead seamless implementation manufacturing engineering processes effective decision making processes furthermore concurrent material flow analysis possible early stages product development production elsevier rights reserved
background expression quantitative trait loci eqtl databases represent valuable resource link disease associated snps specific candidate genes whose gene expression significantly modulated snp investigation previously identified signal inhibitory receptor leukocytes sirl powerful regulator human innate immune cell function constitutively high expressed neutrophils monocytes sirl surface expression varies strongly individuals underlying mechanism regulation genetic control well potential clinical implications explored yet methods whole blood eqtl data chinese cohort used identify snps regulating expression vstm gene encoding sirl genotype effect validated flow cytometry cell surface expression correlated electrophoretic mobility shift assay emsa chromatin immunoprecipitation chip bisulfite sequencing methylation functional impact studied inhibition reactive oxygen species ros results found significant association single cpg snp rst located promoter vstm flow cytometry analysis confirmed primarily monocytes protein level sirl strongly associated genotype snp monocytes allele snp facilitates binding transcription factors latter recently shown act docking site modifiers dna methylation line notion rst associates complete demethylation vstm promoter correlating allele specific upregulation sirl expression monocytes upregulation strongly impacts iga induced production ros cells targeted association analysis found significant meta value association atopic dermatitis conclusion low expression sirl monocytes associated increased risk manifestation inflammatory skin disease thus underlines role cell subset inhibitory immune receptor maintaining immune homeostasis skin notably genetic regulation achieved single cpg snp controls overall methylation state promoter gene segment
nontoxic natural products useful skin care cosmetics considerable interest tyrosinase rate limiting enzyme inhibitor useful developing whitening cosmetics pyracantha koidzumii hayata rehder endemic species taiwan exhibits tyrosinase inhibitory activity find new active natural compounds koidzumii performed bioguided isolation studied related activity human epidermal melanocytes total compounds identified koidzumii present study including two new compounds dihydroxy dimethoxy dibenzofuran dihydroxy methoxybiphenyl glucopyranoside well known compounds new compound exhibited maximum potency inhibiting cellular tyrosinase activity protein expression cellular tyrosinase tyrosinase related protein well mrna expression paired box microphthalmia associated transcription factor concentration dependent manner enzyme kinetic assay new compound acted uncompetitive mixed type inhibitor substrate dihydroxyphenylalanine value substrate calculated using lineweaver burk plots taken together findings show compound exhibits tyrosinase inhibition human melanocytes compound may potential candidate use cosmetics
introduction walnut leaf contains large amounts antioxidants phenolic compounds flavonoids beneficial effect compounds treatment diabetes shown study investigated effect cyclohexane ethanol extract walnut leaf activity sorbitol dehydrogenase sdh enzyme methods fifty six adult male sprague dawley rats divided seven groups treated days follows control diabetic control received sesame oil vehicle control cyclohexane control ethanol received body weight cyclohexane ethanol extracts respectively diabetic cyclohexane received cyclohexane extract diabetic ethanol diabetic ethanol received ethanol extract respectively diabetes induced single injection streptozotocin body weight blood glucose recorded weekly last day treatment animals sacrificed whole blood collection directly heart activity sdh measured serum elisa method results oral administration cyclohexane extract walnut leaf dose diabetic group improved blood glucose significantly compared diabetic groups administration extracts reduced activity sdh compared diabetic control group significantly significant difference body weight treatment groups diabetic control group end treatment period conclusion cyclohexane extract walnut leaf decreased blood glucose significantly extracts reduced activity sdh significantly diabetic animals
power distribution grid exhibits characteristics weak grid owing existence scattered high power distributed power generation devices grid impedance affects robust stability grid connected inverters leading harmonic resonance even instability system therefore study stability grid connected inverters high grid impedance based impedance analysis presented paper output impedance modeling lcl type single phase grid connected inverter derived effects pll loop digital control delays output impedance characteristics taken account enhance stability grid connected inverters different grid impedance novel impedance phased compensation control strategy proposed increasing phase margin grid connected inverters specifically detailed implementation parameter design impedance phased compensation control method depicted finally impedance phased dynamic control scheme combined online grid impedance measurement introduced also verified experiment results
prototype bio catalyzed electrogenic system integrated biological treatment process sbr bet evaluated study specific function anoxic condition electrogenic activity multiphasic approach employed influence bio electrogenic activity optimized initially later optimal anode cathode inter electrode distance enumerated amongst four electrode distances evaluated showed higher power output bioelectrokinetics analysis used validate system performance experimental variation studied redox behavior showed increase cathodic catalytic activity increase inter electrode distance spatiometabolic distribution depicted microbial stratification anode electrochemically active bacteria present anode surface inner outer layers biofilms showed relatively uniform diversity compared suspension culture elsevier rights reserved
flexural bending analysis perfect imperfect functionally graded materials plates hygro thermo mechanical loading investigated present paper due technical problems fgm fabrication porosities micro voids created inside fgm samples may lead reduction density strength materials investigation fgm plates assumed even uneven distributions porosities plate cross section modified rule mixture used approximate material properties fgm plates including porosity volume fraction order elastic coefficients thermal coefficient moisture expansion coefficient plate assumed graded thickness direction elastic foundation modeled two parameter pasternak foundation equilibrium equations given number examples solved illustrate bending response metal ceramic plates subjected hygro thermo mechanical effects resting elastic foundations influences played many parameters investigated
self esteem generally regarded important indicator adolescents mental health assessed self report questionnaire school sample subjects assessed time points years years age within zurich psychology psychopathology study zapps cross lagged panel analyses longitudinal data zapps indicated self esteem predictive internalizing problems impact internalizing symptoms analyses adjusted coping behavior efficiency social networks impact stressful life events self esteem also stable within observed age range controlling prior levels predicted variables findings support impact self esteem mental health indicate importance addressing self esteem prevention intervention programs
purpose review non suicidal self injury nssi common mental health threat among adolescents review aims present current literature epidemiology etiology therapeutic approaches focus period adolescence recent findings nssi widespread among adolescents community well clinical settings lifetime prevalence rates recent studies influenced multiple factors including social contagion interpersonal stressors neurobiological background well emotional dysregulation adverse experiences childhood summary still lack studies regarding psychotherapeutic well psychopharmacological treatment nssi adolescence furthermore sufficient evidence prevention programs missing
among response signals external auditory canal evoked stimulating sounds oaes signal intensity low generally lower bbspl stimulus artifact relatively much stronger stimulus artifact suppression always important thorny issue oaes detection article studies oaes detection algorithm comprehensive application current signal processing method embedded hearing diagnosis system get good effects artifact removal
recent research suggests prosocial outcomes sharing games arise prefrontal control self maximizing impulses used continuous theta burst stimulation ctbs disrupt functioning two prefrontal areas right dorsolateral prefrontal cortex dlpfc dorsomedial prefrontal cortex dmpfc used ctbs right control area tested subjects prosocial inclinations unsupervised dictator game allocated real money anonymously low high socioeconomic status ses players ctbs two prefrontal sites made subjects generous compared specifically ctbs dlpfc increased offers high ses players ctbs dmpfc caused increased offers low ses players data first demonstrate effect disruptive neuromodulation costly sharing suggest dlpfc mpfc exert inhibitory control prosocial inclinations costly sharing though may different ways dlpfc may implement contextual control dmpfc may implement tonic form control study demonstrates humans prepotent inclination toward prosocial outcomes cognitive control reduced even prosocial decisions carry strategic benefit concerns reputation minimized
hydrogen sulfide third gasotransmitter plays important roles cancer biological processes endogenous exerts pro cancer functions inhibition production cancer cells may provide new cancer treatment strategy achieved via regulation function cystathionine beta synthase cbs one main metabolic enzymes synthesizing enzyme plays important roles development progression colon ovarian cancer primarily regulating mitochondrial bioenergetics accelerating cell cycle progression present study firstly investigated role cbs system human hepatoma cells inhibitory effect quinolone indolone conjugate qic system cbs overexpressed human hepatoma hepg smmc cells inhibition endogenous cbs significantly reduced viability growth rate well proliferation smmc cells meanwhile cbs knockdown caused multiple effects including apoptosis smmc cells increase bcl associated protein bax cell lymphoma leukemia bcl ratio activation caspase polyadp ribose polymerase parp compared scramble sirna sirna transfected groups heme oxygenase microsomal enzyme expression significantly decreased reactive oxygen species ros level increased cbs sirna transfected smmc cells qic significantly reduced smmc cell viability dose dependent manner showed lower toxicity human normal liver cells relative positive controls sunitinib doxorubicin dox compound also inhibited cell proliferation induced cell apoptosis smmc cells analysis indicated qic downregulated cbs system decreased protein glutathione gsh levels increased ros level activated caspase cascade collectively results demonstrated cbs system plays important roles human hepatoma cells qic significantly inhibited cell growth via downregulation system
purpose paper analyze concept transformative pedagogy physical education sport pedagogy pesp research order provide alternative perspective freedom justice limits transformation although limits already pointed literature limits presented though originating resolved socio cultural political contexts attempt redirect attention social personal paper points possibility limits also within critical pedagogues researchers analyzing three barriers self consciousness knowledge two viable methods developing transformation provided
possible detect pathology alzheimer disease many years symptoms signs otherwise become manifest biomarkers disease include evidence amyloid tau cerebrospinal fluid neuroimaging instance allows amyloid brain visualized thus preclinical state possible identify alzheimer pathology long clinical evidence disease much research focuses preclinical state seems likely treatments effective disease established means researchers discover alzheimer pathology years person risk developing condition memory clinics people may present early prodromal symptoms yet amount dementia syndrome mild cognitive impairment yet biomarker evidence dementia highly likely develop problematic people required consent disclosure findings indicate uncertain risk alarming disease carried scoping review issues arise connection diagnosis preclinical dementia identified four themes literature stigma ethical issues psychological burden language shall discuss themes related issues emerge meaning medicalization virtues values research required understand issues detail emphasis breadth research must biopsychosocial ethical elsevier rights reserved
aim paper demonstrate applicability effectiveness computationally demanding stereo matching algorithm different low cost low complexity embedded devices focusing analysis timing image quality performances various optimizations implemented allow deployment specific hardware architectures decreasing memory processing time requirements reduction color channel information resolution input images low level software optimizations parallel computation replacement function calls loop unrolling reduction redundant data structures internal data representation feasibility stereo vision system low cost platform evaluated using standard datasets images taken infra red cameras analysis resulting disparity map accuracy respect full size dataset performed well testing suboptimal solutions
remarkable advances made treatment inflammatory bowel disease since introduction anti tumor necrosis factor alpha agents especially patients refractory tolerate conventional therapies currently infliximab adalimumab golimumab available east asian medical market agents shown effective inducing maintaining long term remission inflammatory bowel disease despite clinical benefits anti tumor necrosis factor therapy also lead increased vulnerability infections development autoimmune diseases malignancy decreased immunogenicity vaccinations infectious diseases tuberculosis hepatitis influenza remain major health problems east asia cautious use biologics needed improve treatment efficacy safety close monitoring inflammation regular surveillance malignancy regularly scheduled vaccinations needed treatment strategies biologics customized meet needs different patients
introduction increasingly imperative retain new graduates order meet growing health workforce needs australia ageing population concurrently need prepare graduates work effectively interprofessional teams providing interprofessional educational opportunities tertiary level although skills knowledge competencies delivered interprofessional context point contention limited attention given identification crossprofessional gaps entry level work readiness graduate health professionals could subsequently addressed extent interprofessional education methods qualitative responses collected department health western australia employees using survey tool open fields respondents recent graduates across range health professions responses analysed identify significant self reported gaps graduate work readiness impact results gaps entry level work readiness across multiple professions identified included caseload time management clinical administration skills employability lack experience high risk patients emergencies insufficient practicum transform theory practical knowledge conflict management stress management reality shock conclusion gaps identified current graduate work readiness across range health professions inform focus future interprofessional training paper could play role ensuring graduates work ready also provide ideas building interprofessional skills future workforce
due strict discussions regarding energy saving goal reduce emissions specified year bumd strong demand lighter lightweight design automotive structures support energy saving targets view holistic approach prospectively meet requirements automotive sector economic production orientated aspects well joining technologies within scope multi material design must also considered achieve great leap towards medium large scale production accomplish goals comprehensive method urban vehicle concepts electric powertrain necessary vehicle structures presented dimensions packaging presented vehicle based demands future urban vehicle four passenger capacity includes baggage steerable front system wheels rear axle electric powertrain beginning method relevant user requirements space occupants baggage range urban vehicle defined addition input variables discharged state art electric vehicles step important consider additional requirements crash requirements requirements electrical components vehicle design defined requirements package urban car defined two paths determined geometrically simulative way simulative consideration limited vehicle longitudinal dynamics thus rough dimensioning drive components derived outputs simulation performance measures converted components overall model dimension example electric motor battery geometric design phase begins positioning occupants passenger compartment ergonomic layout based conception complete vehicle various fem optimisations topology topography size carried body white order construct structures individual functional components modules top approach gives opportunity obtain constructive innovations must integrated within early concept phase also reduce costs aiming develop series product holistic approach load specific optimised structural design generated virtually evaluated outlook dynamic loads crash behaviour also given focus potential innovations definition novel package alignments combination useful application multi material design methods resulting light modular vehicle structure published elsevier
often touted attractive attributes printed organic electronics mechanically flexible form factor low cost green demand printing scalability low power operation intelligence signal processing ideally creation intelligent lightweight electronics printed simple ubiquitous printing processes integrated new ways exploit mechanically flexible form factor printed organic electronics industry right recognized one key technological enablers internet things largely complementary silicon printed transistors slow printed elements large sanguine projected growth market today assumes intelligence analog mixed signal digital signal processing would realizable nevertheless many said attributes printed organic electronics remain challenge paper exemplify comprehensive critical review tabulation state art printed digital analog mixed signal circuits review application space printed organic electronics supply chain including classifications delineate associated challenges constituent chain challenges largely unresolved indeed formidable discussed critical circuits systems perspective review depicts contemporary design philosophies methodologies silicon largely inadequate printed organic electronics end discuss esoteric analog digital design philosophies methodologies emphasis design optimization different constituent supply chains may potentially circumvent said formidable challenges discuss associated penalties thereto
necessary sufficient conditions single output system state equivalent nonlinear observer canonical form found krener isidori paper give new necessary sufficient conditions form algorithm suitable computer programming proof constructive state transformation also nonlinear observer canonical form contained also sufficient part proof rely frobenius theorem
work describes fermentation simultaneous production rhamnolipids ethanol exploded sugarcane bagasse esb using saccharomyces cerevisiae pseudomonas aeruginosa crude enzyme complexes cecs cecs produced aspergillus niger solid state fermentation ssf using different levels esb rice bran corn cob substrates best results rhamnolipids emulsification index surface tension ethanol obtained fermentation esb degrees using cec ssf esb water also observed fermented bagasse approximately calorific value bagasse nature could used potential source energy findings suggest fermentation using aeruginosa cerevisiae esb used successful production rhamnolipids ethanol recovery energy present fermented bagasse elsevier ltd rights reserved
study aims conduct nonlinearity analysis shading effect technical economic performance building integrated photovoltaic blind bipb designed preliminary study evaluate feasibility bipb implementation first terms technical performance bipb shading effect due blind slat bipb nonlinear effect amount electricity generation per unit area aegunit bipb particularly width panel increases aeg unit bipb tends decrease second terms economic performance bipb feasibility bipb depends type investment values specifically width panel increases npv net present value year tends increase however sir saving investment ratio year tends decrease npv determined highest width panel sir determined highest times width panel main findings study used clearly define design specifications bipb implementation ensure meet client expectations various objectives technical performance aeg unit bipb economic performance npv sir elsevier ltd rights reserved
exploratory study carried determine expression levels hepatocyte growth factor hgf insulin like growth factor thyroid stimulating hormone tsh leptin serum tumor samples patients uveal melanoma investigate potential association expression levels disease progression patient survival seventeen patients including nine nonmetastatic eight metastatic included study eighteen healthy individuals served controls levels four proteins serum tissue samples determined enzyme linked immunosorbent assays immunohistochemical staining respectively associations protein levels survival disease progression clinicopathological factors analyzed statistically serum levels hgf significantly higher tsh levels lower uveal melanoma patients healthy individuals level neither protein differed significantly metastatic nonmetastatic groups four proteins tested serum tsh significantly associated patient survival correlation observed tissue serum levels protein levels hgf serum may markers uveal melanoma development prognostic predictive values potential markers need determined larger cohort
harmonic response interaction unified power flow controller electrical network presented paper upfc model harmonic studies presented model incorporates basic operating characteristics existing fundamental frequency upfc models offer active reactive power regions however harmonic model offers richer information harmonic distortion regions upfc model given form equivalent impedance connected system perform harmonic propagation resonance prediction analysis resorting modularity upfc model obtained connection two voltage source converters system model used study harmonic response upfc interaction transmission lines copyright john wiley sons ltd
paper presents summary doctoral dissertation author addresses task context based reasoning ambient intelligence
study proposes novel method eliminate limit cycle caused low resolution analogue digital converter adc digitally controlled converter reduced state kalman filter proposed get optimum estimate output voltage noisy measurement provided low resolution adc proposed scheme simulated bit resolution adc validation performed different resolutions using prototype model implemented bit digital signal processor results show proposed scheme eliminates limit cycle oscillation completely computationally efficient
many global identification approaches described literature estimating linear parameter varying lpv discrete tin time state space models affine dependence scheduling parameter suffer heavily curse dimensionality making identification moderate sized systems computationally intensive infeasible paper present novel two step approach estimate lpv models based single data set varying scheduling signal combining lpv correlation analysis deterministic lpv realization scheme step includes estimation sub markov parameters system using correlation analysis involved signals subsequently step paper presents novel basis reduced exact kalman like realization scheme uses sub parts extended hankel matrix therefore computational complexity significantly reduced compared full scheme demonstrate basis reduction lead loss performance simulation study provided ifac international federation automatic control hosting elsevier ltd rights reserved
veterans affairs largest integrated health care system united states responsible care population disproportionately high rate ckd ensuring access kidney health services imperative one facet strategy reduce ckd leverage use teletechnology expand outreach veterans kidney disease wide array teletechnology services deployed pull veterans push kidney health services veterans preferred health care venue teletechnology thus expands veteran choice facilitates access care furthers goal delivering patient centered kidney specialty care demonstrated feasibility virtual delivery kidney specialty care services education via synchronous asynchronous approaches challenges ahead include determining relative health care value kidney telehealth services identifying veterans likely benefit specific technologies optimizing adoption effective kidney telehealth services providers patients alike ensure optimal timely kidney health care delivery
comprehensive mathematical model proposed calculate optimal leg length cross section area teg unit maximize peak output power model shows teg unit exists optimal ratio leg length leg cross section area corresponding maximum peak output power convective thermal boundary condition optimal leg length cross section area calculated based optimal ratio mathematical model also validated paper corresponding error within reasonable range moreover effects leg length leg area peak output power peak output power density efficiency teg unit different thermal boundary conditions also discussed study provide guidance structure design optimization teg unit elsevier ltd rights reserved
depression often associated weight gain underlying mechanisms unclear study assessed whether three psychological eating styles emotional eating external eating restrained eating act mediators depression weight gain used structural equation modelling test hypothesized mediation models sample fathers mothers assessing self reported eating styles dutch eating behavior questionnaire depressive feelings depressive mood list body mass index bmi baseline bmi five years model emotional eating also assessed moderation effect httlpr genotype sub sample caucasians analyses performed separately two sexes although overall effect depression weight gain statistically non significant sexes causal chain depression emotional eating weight gain mothers depressive symptoms related higher emotional eating emotional eating predicted greater increases bmi independently depression moreover indirect effect via emotional eating depression bmi change significant beta mediation effect found independent httlpr genotype mediation effect found fathers external eating restrained eating act mediators depression weight gain either sex finding emotional eating acted mediator depression weight gain mothers suggests obesity interventions take emotional eating account elsevier ltd rights reserved
new approach unified treatment frictional contact orthotropic plasticity finite strains using semi smooth newton methods presented contact discretization based well known mortar finite element method using dual lagrange multipliers facilitate handling additional lagrange multiplier degrees freedom exploiting similarity typical inequality constraints plasticity friction involved discrete inequalities reformulated nonlinear non smooth equations using complementarity functions resulting set discrete semi smooth equations solved efficiently variant newton method additionally introduced variables condensed global system linear system consisting displacement degrees freedom solved iteration step contrast classical radial return mapping methods computational plasticity plastic constraints required hold every iterate nonlinear solution procedure convergence relaxation pre asymptotic behavior results increased flexibility regarding algorithm design potentially higher robustness compared radial return mapping algorithms presented elasto plasticity algorithm includes arbitrary isotropic hyperelasticity anisotropic hill type yield function isotropic kinematic hardening plastic spin appropriate finite element technology nearly incompressible materials therefore well suited modeling sheet metal forming similar processes several numerical examples underline robustness proposed plasticity algorithm efficient treatment elasto plastic contact problems elsevier rights reserved
infrahumanisation studies shown people use ability experience secondary emotions compared primary emotions characteristic discriminates outgroups result widely supported extensive range research work however still know certain conditions tendency mitigated aim study twofold one hand determine whether solidarity intergroup context results human representation outgroups hand verify infrahumanisation bias mitigated purpose three vignettes elaborated first included description outgroup german people emphasising laboriousness charm second described taking refugees balkan war finally text dealing solidarity general without specific reference german people presented two step experimental design first participants attribute secondary primary emotions outgroup answer lexical decision task registered strength association secondary emotions ingroup outgroup results show vignettes intergroup solidarity contribute humanising representation outgroup reduce infrahumanisation bias
background clinical trial data shown apremilast oral phosphodiesterase inhibitor efficacious safe treatment psoriasis however little real world experience using apremilast community setting documented objectives many patients psoriasis often unresponsive various treatment modalities including topical systemic biologic medications aim chart review assess overall patient experience using apremilast treat psoriasis methods retrospective chart review electronic medical records conducted patients prescribed apremilast community dermatology practice results patients prescribed apremilast patients took least dose patients apremilast improved clinical disease severity patients achieving body surface area treatment generally well tolerated caused serious adverse events commonly reported side effect resulting discontinuation treatment apremilast nausea vomiting conclusions overall apremilast safe well tolerated treatment significant clinical improvement patient population
background postoperative delayed paradoxical depression pdpd psychiatric condition described patients without history mood disorders undergo major surgery without complications become clinically depressed pdpd recognized major surgical interventions including coronary artery bypass surgery sought determine incidence potential factors associated pdpd surgical treatment unruptured intracranial aneurysms methods cohort patients derived prospective observational data set consecutive cases intracranial aneurysms accrued starting patients pdpd identified psychiatric treatment outcomes documented incidence pdpd baseline characteristics analyzed multivariate logistic regression performed analyze associations variables pdpd patients preoperative depression bipolar disorder excluded results patients found newly diagnosed major depressive disorder surgical treatment intracranial aneurysms univariate multivariate analysis significant difference groups full return daily activities odds ratio confidence interval result cause pdpd patients pdpd recovered fully psychotherapy pharmacotherapy without intervention conclusions pdpd uncomplicated unruptured aneurysm surgery surprising neurosurgeon patient promptly identified addressed achieve full recovery pdpd interpreted mild variant post traumatic stress disorder
study proposes hybrid controller combining proportional integral derivative pid control model reference adaptive control mrac named pid mrac controller convergence performances pid control mrac hybrid pid mrac also compared simulation matlab results show convergence speed performance mrac pid mrac controller better pid controller addition convergence performance hybrid control better mrac control
new delivery mode integrated project delivery ipd relies highly trust based collaboration among project parties thus selecting appropriate parties important successful ipd although traditional selection methods primarily based lowest tender price multiple criteria price help select parties complete integrated project completely suitable ipd trust collaborative relationship among project parties considered improve upon shortcoming established methods new method based concept interorganizational transactive memory system tms established paper tms drives group members mutually trusting cooperatively integrate professional knowledge reflects idea collaboration underlies ipd study party selection ipd achieved via two processes first study developed tms rating scale conducted questionnaire based analysis verify reliability validity quantitatively second study selected appropriate combination seven combinations party candidates addition study analyzed appropriate combination using social network analysis sna results suggest project parties low tms degree engage frequent interaction foster mutual cognition trust improve team collaboration ipd american society civil engineers
osteoarthritis one common chronic diseases characterized degradation articular cartilage previously reported xanthan gum injection preparation high molecular weights ranging could enhance viscosity synovial fluid protect joint cartilage rabbit therapeutical effect significance difference existing clinical medication sodium hyaluronate injection frequency weekly weeks herein prepared injection preparation low ranging evaluated therapeutical effect therapy every weeks weeks weekly weeks reference model induced using anterior cruciate ligament transection aclt rabbit vivo also using sodium nitroprusside snp cell culture vitro results showed could also protect cartilage damage decrease concentration nitric oxide synovial fluid reverse amplification knee joint width similar previously reported cellular level promotes proliferation decreases apoptosis chondrocytes mechanistically molecular level effects elicited via regulation protein levels caspase bax regulation protein levels bcl cartilage vivo vitro results showed maybe become excellent candidate long acting drug treating published elsevier ltd
failure detector approach solving distributed computing problems celebrated modularity approach allows construction algorithms using abstract failure detection mechanisms defined axiomatic properties building blocks minimal synchrony assumptions communication enable implement failure detection mechanism studied separately synchrony assumptions typically expressed eventual guarantees need hold point time forever deterministically practice never synchrony assumptions may hold probabilistically temporarily paper study failure detectors realistic distributed system asynchrony inflicted probabilistic synchronous communication address following paradox implementation consensus probability possible without using randomness algorithm implementation lozenge probability impossible achieve lozenge weakest failure detector solve consensus problem many equivalent problems circumvent paradox introducing new failure detector lozenge variant lozenge probabilistic temporal accuracy prove lozenge implementable provide optimal lozenge algorithm interestingly show lozenge replace lozenge several existing deterministic consensus algorithms using lozenge yield algorithm solves consensus probability fact show result holds decisive problems consensus also failure detector lozenge lozenge resulting algorithms combine modularity distributed computing practices practicality networking ones
work aims evaluate potential effects amino butyric acid gaba fortified barley bran chronic stress induced sprague dawley rats animals divided four groups based diet control group stress treatment str stress plus dietary panax ginseng positive control group str stress plus gaba fortified barley bran str days stress biomarkers liver toxicity biomarkers measured stress biomarkers adrenocorticotropic hormone acth corticosterone decreased str group compared str group similar results obtained liver toxicity biomarkers aspartate transaminase alanine transaminase high density lipoprotein cholesterol higher str group str group results suggest gaba fortified barley bran potentially used manage stress related disorders rodents practical applicationsgaba neurotransmitter known various medicinal properties reduces anxiety depression insomnia also antihypertensive anticancer activity therefore development gaba fortified food great interest study investigates anti stress effects gaba fortified barley bran sprague dawley rats animals supplemented gaba fortified barley bran exhibited fewer stress effects study sheds light potential functional foods nutraceuticals enriched cereals stress management results study could serve foundation research fortified cereals promote consumption fortified cereals large scale
paper examines water depth variations vertical slot fishways vsfs without central baffle three experimental models built research results show adjoining pools fore aft elevation difference prevent obvious fluctuation water depth instead uniform along fishway water depth affected upstream downstream water levels fluctuations water levels exert impact dozen pools end fishway water line characteristics different downstream water depth greater smaller normal conditions working condition backwater water depth increases uniformly pools backwater section condition drawdown depth falls faster pools closer end fishway two flow profiles obtained vfs analyzed bakhmeteff chow method findings help enhance understanding hydraulic design fishway improve efficiency vsfs
human interaction communication verbal messages also nonverbal behavior nodding paralanguage rhythmically related mutually synchronized among speakers synchrony embodied rhythms unconsciously enhances sense unification causes interaction activated communication nonverbal behaviors body movements speech activity increase embodied interaction activated paper propose concept estimation model interaction activated communication based heat conduction equation characteristics precipitous speed fluctuation develop model estimates degree interaction activated communication using speech input evaluate developed model estimating period interaction activated communication avatar mediated communication results demonstrate developed model effective estimating interaction activated communication
monotremes unique group mammals whose young incubated leathery shelled egg fed milk teatless areolae hatching soon hatch monotreme young must able maneuver around nest maternal pouch locate areolae stimulate milk ejection present study embryological collections museum fur naturkunde berlin used follow development monotreme cerebellum incubation lactational phases determine whether cerebellar circuitry able contribute coordination locomotion monotreme hatchling correlate cerebellar development behavioral maturation structure developing monotreme cerebellum arrangement transitory neuronal populations similar reported fetal neonatal eutherians time course key events later cerebellar development spread much longer period expansion rostral rhombic lip formation nuclear cortical transitory zones occurs time hatching end first post hatching week deep cerebellar neurons begin settle definitive positions purkinje cell layer distinguished granule cell formation also prolonged many post hatching months external granular layer persists weeks hatching findings indicate cerebellar circuitry unlikely contribute coordination movements monotreme pen hatching period activities likely controlled spinal cord medullary reticular formation circuitry copyright karger basel
background aims nursing homes complex healthcare systems serving increasingly sick population nursing homes must engage patients advance care planning inconsistently video decision support tools improved advance care planning small randomized controlled trials pragmatic trials increasingly employed health services research although commonly nursing home setting well suited report presents design rationale pragmatic cluster randomized controlled trial evaluated real world application advance care planning video program two large nursing home healthcare systems methods pragmatic trial video education nursing homes conducted nursing homes intervention control owned two healthcare systems month implementation period intervention facilities instructed offer advance care planning video program patients control facilities employed usual advance care planning practices patient characteristics outcomes ascertained medicare claims minimum data set assessments facility electronic medical record data intervention adherence measured using video status report embedded electronic medical record systems primary outcome number hospitalizations person day alive among long stay patients advanced dementia cardiopulmonary disease rationale approaches facility randomization recruitment intervention implementation population selection data acquisition regulatory issues statistical analyses discussed results large number well characterized candidate facilities enabled several unique design features including stratification historical hospitalization rates randomization prior recruitment control intervention facilities ratio strong endorsement corporate leadership made randomization prior recruitment feasible participation facilities randomized intervention arm critical regulatory issues included minimal risk determination waiver informed consent determination nursing home providers engaged human subjects research intervention training implementation initiated january using corporate infrastructures new program roll guided standardized training elements designed research team video status reports facilities electronic medical records permitted real time adherence monitoring corrective actions centers medicare medicaid services virtual research data center allowed rapid outcomes ascertainment conclusion must rigorously evaluate interventions deliver patient focused care increasingly frail nursing home population video decision support practical approach improve advance care planning pragmatic trial video education nursing homes potential promote goal directed care among millions older americans nursing homes establish methodology future pragmatic randomized controlled trials complex healthcare setting
among patients years new antiosteoporosis medications aom primary care year cessation higher men smokers patients missing lifestyle data normal bmi lower aged recent fractures anti osteoporotics suggesting non severe osteoporosis less risk awareness purpose low compliance anti osteoporosis medications aom previously reported aimed estimate year cessation rates different aoms used spanish healthcare settings identify associated risk factors methods cohort study performed using primary care records data bifap patients entered cohort aged years year data available identified incident users aom year washout participants divided six cohorts alendronate oral bisphosphonates selective oestrogen receptor modulators strontium ranelate teriparatide denosumab patients followed therapy initiation earliest cessation day refill gap switching alternative aom loss follow death end one year therapy cessation estimated using life tables hazard ratios cessation according age sex lifestyle factors morbidity medication estimated stepwise backwards selection results total aom users identified women mean age one year cessation overall highest strontium ranelate lowest denosumab cessation probability higher men fold smokers patients missing bmi smoking data overweight obese underweight fold increase compared normal weight patients aged years recent fracture drugs used osteoporosis better persistence conclusions half patients initiating aom stopped therapy within first year initiation described risk factors cessation could proxies non severe osteoporosis disease risk awareness could inform targeting high risk patients monitoring interventions aimed improving persistence
presence joints fractures rocks strongly influences behavior rock mass dividing media smaller units structures intensify potential instability besides development sliding rotational movements assumption discontinuum media changes whole analysis conditions relation continuum analysis acquisition geometrical structural discontinuity data alongside mechanical properties paramount importance rock mass analysis orientation spacing expansion geometrical characteristics rock mass relative geometrical position studied projects influence pattern potential failure therefore inevitably first step involved analysis rock mass geometric data collection discontinuities crucial step analysis study traditional data collection methods structural discontinuities disadvantages reviewed discontinuity data collection based digital image analysis developed applied case study several walls choghart iron ore mine results obtained show method good accuracy assessing fine structures also collects data much shorter time study therefore suggests proposed method used practical approach
objective objective investigation assess potential effect obesity effectiveness hormonal contraceptives hcs study design meta analysis conducted using individual participant data directly phase clinical trials combination oral contraceptives cocs rather extracting summary data literature trials selected reviewed food drug administration fda conducted north america six day cycle equivalents exposure readily retrievable participant level data contraceptive effectiveness measured pearl index number pregnancies per woman years women aged risk unintended pregnancy incidence rate ratio irr ratio pis obese women defined body mass index bmi compared non obese women bmi calculated cox proportional hazard regression model fixed random effects used estimate hazard ratios hrs unintended pregnancy obese women compared non obese women results seven clinical trials cocs obese non obese women met inclusion criteria meta analysis trial varied obese non obese women pooled estimated using direct weighted average method obese non obese women pooled irrs estimated using direct weighted average mantel haenszel adjustment methods comparable respectively overall meta analysis suggested higher pregnancy rate coc use obese women adjusting age race implications statement obesity may increase risk unintended pregnancy women using cocs data obese women ongoing future phase clinical trials necessary allow evaluation topic conclusions results meta analysis suggest obese women may higher pregnancy rate coc use compared non obese women future analysis assess differences pharmacodynamics compliance could potentially account observed difference unintended pregnancy rates published elsevier inc
background advancement high throughput technologies enrichment popular public databases research focuses bioinformatics research computational integration network gene expression profiles extracting context dependent active subnetworks many methods subnetwork searching developed scoring searching algorithms present range computational considerations implementations primary goal present study comprehensively evaluate performance different subnetwork detection methods eleven popular methods selected comprehensive comparison results first taking account dependence genes given protein protein interaction ppi network simulated microarray gene expression data case control conditions method applied simulated data subnetwork identification second large microarray data set prostate cancer used assess practical performance method using simulation studies real data application evaluated performance different methods terms recall precision conclusions jactivemodules pinnaclez wmaxc performed well identifying subnetwork relative high precision recall bionet performed well precision none methods outperformed methods overall users choose appropriate method based purposes studies
ballasted railroads form integral part modern transportation infrastructure australia however subjected large stresses especially mixed traffic lines heavy freight trains operated adverse operational conditions ballast progressively degrades contributing overall track deformations frequent maintenance maintaining geometry ballast embankments necessary improve safety efficiency railway operations use artificial inclusions geosynthetics shock mats well recycled discarded ballast track economically viable options order gain insight cgre conducted extensive field trials two rail lines bulli singleton new south wales supported sydney trains australian rail track corporation respectively studies different types geosynthetics geogrid geotextile geocomposite shock mats installed beneath ballast layer constructed varying subgrade conditions relative advantages different geogrids studied traffic induced stresses ballast breakage transient permanent deformations routinely monitored using precise instrumentation schemes paper discusses details track construction instrumentation monitoring processes results field studies
paper presents various experimental tests sensorless capability induction motors intentionally created saliency introduced rotor allow rotor position estimated means high frequency injected signal stator winding experimental measurements carried three prototypes two saliency third without saliency reference critical aspects prototype realization discussed paper suggestion solve machine design point view included rotor saliency measured means injection steady state performance measured together mechanical characteristic three prototypes analysis used predict variation parameters rotor position results compared achieved measurements
present approach scalable long term preservation data stored relational databases rdbs rdf implemented saq semantic archive query system proposed approach suitable archiving scientific data used scientific publications desirable preserve parts rdb data specific set experimental artefacts database approach long term preservation rdf selected parts database specified archival query extended sparql dialect sparql query processing based automatically generating rdf view relational database archive called view sparql provides flexible selection data archived terms sparql like query view result archival query data archive file containing rdf triples representing relational data content preserved system also generates schema archive file sufficient meta data saved allow archived database fully reconstructed archival query usually selects properties values sets subjects makes property triple patterns unknown call queries properties unknown unbound property queries achieve scalable data preservation recreation propose query transformation strategies suitable optimizing unbound property queries query rewriting strategies implemented evaluated new benchmark archival queries called abench abench defined set typical sparql queries archiving selected parts databases generated berlin benchmark data generator experiments saq optimization strategies evaluated measuring performance sparql queries selecting triples archival abench performance equivalent sparql queries related systems also measured results showed proposed optimizations substantially improve query execution time archival queries
use internet among adolescents opportunity personal development also potential source problems risks social cultural aspects related gender could priori determine patterns internet social networks usage well resulting consequences aim present study explore possible gender differences regarding internet usage habits reasons use online risky behaviors problematic internet use piu parental role achieve goal sample spanish compulsory secondary school students aged analyzed results obtained confirmed relevant gender differences reasons using social networks mobile phone instant messaging use differences prevalence piu risky practices cyberbullying parental role also detected findings allow discussing interpretative keys gender perspective
paper presents results pilot scale study consisting pre treatment granular activated carbon gac filter followed membrane filtration detailed characterisation rainwater tanks highlighted turbidity dissolved organic carbon doc heavy metals particular lead compliant australian drinking water guidelines adwg organic matter present water causes membrane fouling leads carcinogenic compounds upon chlorination gac filter used first step remove dissolved organic matter measured terms doc particular also reduce concentration turbidity lead membrane filtration remove remaining solids reducing concentrations turbidity microorganisms study pilot scale rainwater treatment system consisting gravity fed gac filter membrane filter ultra flo operated period days performance system assessed terms membrane flux improvement water quality measured australian drinking water guidelines determination flux especially later stages membrane operation important able size filters manner meets expected demand treatment system gac filter membrane filter effective reducing turbidity doc heavy metals system reduced turbidity levels ntu adwg limit ntu concentration doc reduced australian drinking water guidelines limit concentration lead reduced less adwd limit concentrations heavy metals well within adwg limits gac filter removed majority organic substances raw rainwater collected roof initial flux decline stable flux achieved consistently final days experiment
hepatocellular carcinoma hcc among common types cancer liver transplantation surgical resection primary surgical treatment options hcc aim study assess mortality within years postdiagnosis among patients hcc according treatment modalities examined data surveillance epidemiology end results seer medicare database seer registries collect demographics cancer stage historical types treatments medicare claims include diagnoses procedures survival status beneficiary patients hcc identified using international classification disease oncology third edition site code histology code treatment modalities nonsurgical treatment total cases included age diagnosis years male white hcc patients underwent younger years sicker presence decompensated cirrhosis less likely die within years compared patients multivariate analysis older age stage hcc local treated independent predictors mortality within years furthermore presence decompensated cirrhosis alcoholic liver disease increased within years mortality mortality within years postdiagnosis hcc significantly higher patients treated
classifying measurement data become core problem photogrammetry computer vision since rise modern multiview geometry techniques combined affordable range sensors introduce markov random field based approach segmenting textured meshes generated via multi view stereo urban classes interest input mesh first partitioned small clusters referred superfacets geometric photometric features computed random forest trained predict class superfacet well similarity neighboring superfacets similarity used assign weights markov random field pairwise potential account contextual information classes experimental results illustrate efficacy accuracy proposed framework published elsevier behalf international society photogrammetry remote sensing inc isprs
paper deals low offset operational amplifiers shows innovative approach design operational amplifier opamp combines two different techniques make able handle technological radio frequency interference rfi induced offset
purpose review middle east north africa witnessed dramatic transformation last years caused rapid urbanization modernization significant changes diet lifestyle review attempts highlight recent data regards ischemic heart disease risk factors region recent findings ischemic heart disease leading cause death region age presentation myocardial infarction acute coronary syndrome appears significantly younger global averages increased rates major risk factors including diabetes hypertension hyper lipidemia smoking obesity sedentary lifestyle noted specifically significant changes dietary habits growing epidemic use alternative tobacco products noted summary review article highlights growing epidemic ischemic heart disease region led dramatic increases incidence risk factors epidemic require multipronged approach address varied issues mitigate growing prevalence disease
paper examines cytotoxic effect nine compounds spiropyrazoline structures determines reaction mechanism diazomethane selected benzylideneflavanones lipophilicity binding ability human serum albumin cytotoxic effect determined two human leukaemia cell lines nalm melanoma cells well normal human umbilical vein endothelial cells huvec highest cytotoxicity exhibited compound found less three cancer cell lines five fold lower sensitivity normal cells huvec compounds exhibit comparable affinity energy human serum albumin binding kcal mol vary binding sites depending substituent ray crystallography two derivatives confirmed synthetic pathway structures carefully examined elsevier rights reserved
outbreak acute hepatitis recently occurred nursing home zhejiang province china objectives study confirm outbreak identify aetiology source transmission patterns residents staff near nursing home period october may investigated regarding hygiene epidemiological information including water food eating meat especially pork products serum stool specimens collected detection hepatitis virus hev antibodies using elisa rna using pcr samples rna positive genotyped senior residents staff nursing home laboratory confirmed cases outbreak cases patients three deaths symptomatic jaundice common clinical symptom hepatitis infection hev strains isolated three cases formed single cluster within genotype case control study conducted investigate potential risk factors outbreak results revealed cases often washed dishes rinsed mouths using tap water controls based hygiene investigation meteorological information likely hev infected sewage faeces contaminated water network rainy days collectively results suggest outbreak hev genotype infection likely caused contaminated tap water rather food
combination electric motors internal combustion engines hybrid electric vehicles hev considerably improve fuel efficiency compared conventional vehicles order use full potential predictive intelligent control system using information impending driving situations developed determine optimal gear shifting strategy torque split combustion engine electric motor increase fuel efficiency vehicle velocity used additional degree freedom development predictive algorithm calculating good choices degrees freedom time necessary paper optimization based algorithm combined energy management economic driving limited horizon proposed results compared results offline calculation determine overall fuel savings potential use discrete dynamic programming algorithm elsevier ltd rights reserved
psychopathy research plagued enigma psychopaths reliably act immorally also accurately report whether action morally wrong current study revealed cooperative suppressor effects conflicting subsets personality traits within construct psychopathy might help explain conundrum among sample adult male offenders ranked deserved punishment crimes psychopathy checklist revised pcl total scores linearly correlated deserved punishment task performance however null results masked significant opposing associations task performance factors psychopathy pcl interpersonal affective manipulative callous factor positively associated task performance pcl social deviance impulsive antisocial factor simultaneously negatively associated task performance relationships qualified significant interaction interpersonal affective traits positively associated task performance social deviance traits high social deviance traits negatively associated task performance interpersonal affective traits low interaction helped reveal significant nonlinear relationship pcl total scores task performance individuals low high pcl total scores performed better middle range pcl total scores results may explain enigma individuals high psychopathic traits groups antisocial individuals usually normal moral judgment laboratory settings still behave immorally especially contexts social deviance traits strong influence
increasingly requirement able determine mechanical properties materials micro scale form surface coatings iii nanoscale microstructures consequence micro scale testing important tool developed aid evaluation mechanical properties materials work cantilever beam specimens typically size prepared gallium ion milling deformed situ within fei helios dual beam workstation latter achieved using force probe geometry suitable loading micro scale test specimens thus force displacement measured together observing deformation fracture individual specimens paper considers evaluation mechanical properties particular elastic modulus yield strength fracture strength materials result relatively large deflections micro scale cantilever beams two materials considered first linear elastic single crystal silicon elastic plastic nanocrystalline nickel results discussed respect reproducibility method mechanical testing evaluated properties compared derived alternative procedures
motor driven electric scooters highly eco efficient high performance convenient air pollution free offer certain powerful solution global environmental energy problems paper presents newly developed super rapid charging electric motor driven scooter electric scooter incorporating edlc stack change power source described practical design criteria edlc stack based electric scooter zcs high frequency link converter experimental result running operation performance furthermore pulse power ultracapacitor edlc charger home use proposed practical point view
interaction carthamin human serum albumin hsa investigated multiple spectroscopic analyses surface plasmon resonance spr isothermal titration microcalorimetry itc molecular docking studies fluorescence lifetime measurements implied carthamin quenched intrinsic fluorescence hsa formation new complex via static mode binding affinities regarding interaction obtained spr analysis results demonstrated carthamin could form complex hsa binding affinity high temperature unfavourable interaction itc analyses molecular docking results illustrated hsa shaped proper cavity site embed whole carthamin molecule complex formed depending intermolecular forces including hydrophobic interaction hydrogen bonding electrostatic force moreover circular dichroism fluorescence demonstrated carthamin slightly disturbed microenvironment amino residues affected secondary structure hsa elsevier ltd rights reserved
backgroundyouths family history alcohol drug use disorders greater risk developing substance use disorders peers family histories increased risk may related impaired maturation forebrain circuitry individuals shown altered forebrain activity rest performing cognitive tasks however fully understood forebrain activity altered individuals ultimately alterations may contribute substance use disorder risk methodsin study tested youths performing task examined activations blocks trials blocks trials nogo contrast blocks resultsfh youths significantly greater cerebral activations nogo blocks youths regions including posterior cingulate precuneus bilateral middle superior temporal gyrus medial superior frontal gyrus significant group differences subtraction nogo blocks additionally youths moderately slower reaction times trials blocks conclusionsour findings suggest global activation increase youths modulated density specific inhibitory components task pattern increased activations youths may least partially due impaired forebrain white matter development leading greater activations less efficient neural communication task performance
studies suggest age differences false memories may related deficits frontal lobe functioning flf butler mcdaniel dornburg price roediger psychonomic bulletin review addition research demonstrated item specific encoding reduce false memories younger adults arndt reder journal experimental psychology learning memory cognition present study examined whether younger older adults perform poorly tests designed assess frontal function would less likely benefit item specific encoding false memory paradigm three experiments participants studied categorized word picture lists encoding manipulations designed emphasize either item specific relational processing younger adults high flf older adults showed reduction false memories item specific processing implemented however low flf older adults showed reduction false memories relational processing impoverished results suggest frontal function directly influences engagement distinctive encoding processes
one class classification basic problem machine learning unlike existing typical one class classifiers designed angle probability geometric paper attempts study problem bionics point view using continuous cognition characteristic starting point propose new framework one class classifier named multiple regression model seen natural extension multiple regression one class classification problem paper applies least squares support vector machine lssvm example show modeling process proposed method corresponding one class classifier named one class least squares support vector machine lssvm various simulation real life datasets used test performance proposed lssvm existing popular one class classification methods including parzen kernel density estimation support vector data description gaussian mixture model also applied order achieve comprehensive comparison results show lssvm achieved best performance simulation real life datasets due good robustness highlights efficacy lssvm elsevier rights reserved
high degree uncertainty associated emission inventory china tends degrade performance chemical transport models predicting concentrations especially daily basis study novel machine learning algorithm geographically weighted gradient boosting machine gbm developed improving gbm building spatial smoothing kernels weigh loss function modification addressed spatial nonstationarity relationships concentrations predictor variables aerosol optical depth aod meteorological conditions gbm also overcame estimation bias concentrations due missing aod retrievals thus potentially improved subsequent exposure analyses gbm showed good performance predicting daily concentrations rmse even partially missing aod data better original gbm model rmse basis continuous spatiotemporal prediction concentrations predicted population lived areas estimated annual mean concentration higher population exposed days gbm accurately predicted continuous daily concentrations china assessing acute human health effects elsevier ltd rights reserved
introductionto explore meaning meanings thinking reason contraceptive risk taking among women illuminate phrase actually means used women explanation contraceptive risk taking methodsforty five depth semistructured interviews conducted sexually active women college campus interviews transcribed coded thematically using nvivo resultsi thinking multiple meanings major themes women explanations meaning pushed back minds think would get pregnant think due impairment resulting alcohol use would deal possibility pregnancy later think contraception pregnancy responses based erroneous risk calculations led women believe likely experience pregnancy discussionreasons women give noncontraceptive use may deeper meanings important clinicians researchers think possible underlying meanings acknowledge may different face value statement future clinical questioning women noncontraceptive use research reasons noncontraceptive use take account variability thinking include appropriate follow questions clarify meaning
describe spectrum splitting solar module design approach using ensembles subcells bandgaps optimized spectrum device physics calculations experimental data determine radiative efficiency parameters iii compound semiconductor subcells enable modification conventional detailed balance calculations predict module efficiency retaining computational speed wide search design space accounting nonideal absorption recombination rates due realistic material imperfections allows identify minimum subcell quantity quality electrical connection configuration concentration required module efficiency realistic optical losses modeled contact resistance losses predict module efficiency greater possible electrically independent subcells spectral splitting optic suns concentration assuming optical efficiency electrical efficiency provided subcells achieve average external radiative efficiency short circuit current least ideal examining spectrum splitting solar cells series connected electrically independent subcells identify new design trade independent challenges fabricating optimal bandgap combinations series connected ensembles single set electrical contacts less sensitive lumped series resistance losses ensembles subcells contacted independently contrast ensembles electrically independent subcells achieve lower radiative losses subcells designed good optical confinement distributing electrically independent subcells concentrating receiver module allows flexibility subcell selection fabrication achieve ultra high efficiency conventional iii cell technology
aims postural tachycardia syndrome pots represents autonomic disorder predominantly affecting females years age pots chronic disorder months characterized excessive heart rate increment standing beats min presence characteristic symptoms cerebral hypoperfusion sympathetic activation patients clinically noted describe lower urinary tract symptoms luts although urologic symptoms methodically assessed pots population herein present data pilot study designed identify quantitate overactive bladder oab patients diagnosed pots methods patients admitted vanderbilt autonomic dysfunction center june october evaluation potential diagnosis pots completed validated standardized questionnaire oab oab presentation symptom score subscale analyses conducted subscale health related quality life hrql scores transformed scale higher scores reflecting superior hrql data presented meansd results thirty two females presented evaluation symptoms consistent pots twenty nine women subsequently diagnosed pots patients completing oab questionnaire response rate average age years symptom severity transformed score patients meeting clinical criteria diagnosis probable clinically significant oab nocturia bothersome symptom followed increased daytime frequency urgency conclusions pilot study describes bothersome lower urinary tract dysfunction patients presenting pots assessed patient reported questionnaire data nocturia demonstrated greatest negative impact health related quality life hrql social interaction least affected hrql domain patients dysautonomia data provides critical baseline mechanistic insight disease specific global pathophysiology nocturia oab neurourol urodynam wiley periodicals inc
young carers increased risk developing mental health social problems objective pilot camp based resilience building programme young carers twelve young carers years recruited carers queensland attended day resilience building camp adapted resourceful adolescent program one month camp carers participated semi structured telephone interview thematic analysis used analyse data two key themes emerged first coping self efficacy included subthemes affect regulation interpersonal skills recognition strengths coping ability second key theme social benefits included opportunities respite social engagement overall participants reported enjoying camp would recommend young carers yet able provide suggestions improve future camps implementing integrative resilience building program resourceful adolescent program camp format shows promise way engaging benefiting young carers well selective populations generally
hofmann submitted proposal using timed mating farrowing system program reproductive dates sow herd thus direct breeding production cycle taut developed system periodic farrowing operated thuringia first farms successfully introduced work coincided beginning called industrial methods production eastern livestock first porcine semen collection centers emerged proportion inseminated sows increased total sow population made possible realize nationwide uniform hybrid pig breeding program parallel developed reproductive technology practice establish starting oriented natural sexual cycle grouping sows system periodic farrowing methods cycle synchronization young old sows birth control developed filed either practice production cycles sows producing farms combination sows managed according principle group farrowing system east germany across farm size categories
hidden markov model hmm consisting controlled markov chain binary output considered binary output reports occurrence certain state versus state markov chain transition matrix markov chain depends control vector chosen minimize discounted infinite horizon cost function information provided decision making entire history binary output presents incomplete knowledge markov chain consequence leads stochastic control problem partial observations solution problem control policy consisting two components estimator derive posterior probability distribution markov chain observation set nonlinear control law map estimate control vector paper introduces nonlinear state space representation estimator develops analytical expressions control law presents numerical methods efficient computation optimal control application results optimal management class inventory systems discussed performance optimal control application examined numerical simulations
despite huge health economic burden migraine headache medications approved prophylactic treatment potentially induce serious adverse effects coenzyme coq supplement shown preliminary benefits migraine prophylaxis aimed assess effect adult population open label parallel add match controlled trial eighty patients diagnosed migraine headache based international headache society criteria allocated receiving current preventive drugs current preventive drugs plus coq daily matching baseline characteristics assessed frequency severity attacks reduction attack frequency per month thirty six patients analyzed coq control groups respectively number attacks per month dropped significantly coq group mean decrease among coq control groups respectively significant reduction also evident severity headaches mean decrease among coq control groups respectively reduction frequency attacks per month number needed treat calculated side effects coq observed study suggests coq might reduce frequency headaches may also make shorter duration less severe favorable safety profile
paper describes development nonlinear state space predictive controller based distributed fuzzy neural model presented approach assumes state space representation order obtain compact form model without statement great number parameters needed represent nonlinear relations increase flexibility network set fuzzy inferences used estimate current system states well construct simple predictor needed update future system behavior along defined horizons sampling period optimization task performing quadratic programming minimization assuming imposed constraints system parameters solved performance proposed controller assessed simulation experiments modeling control nonlinear systems complicated dynamics
people small birth poor infant growth increased risk adult cardiovascular disease osteoporosis type diabetes particularly restricted early growth followed increased childhood weight gain relations extend across normal range birth size graded manner reduced size prerequisite addition larger birth size associated risks obesity type diabetes associations appear reflect developmental plastic responses made fetus infant based cues environment influenced maternal characteristics including diet body composition stress exercise levels responses involve epigenetic processes modify offspring phenotype vulnerability ill health results environment infancy childhood later life mismatched phenotype induced development informed developmental cues mismatch may arise unbalanced diet body composition mother change lifestyle factors generations insights offer new possibilities early diagnosis prevention chronic disease
novel integrated fault diagnosis method bit digital analog converter dac circuit presented paper circuit based one presented ieee international test conference itc gain waveforms faulty faults free golden circuits well internal node voltages two stage cmos operational amplifier used detect faults assembled fault detection procedure introduced along localization percentage detectable faults estimation using hspice matlab type test defined minutely accurate effectiveness detecting faulty circuit evaluated
paper active modeling approach pneumatic artificial muscle pam considered pam nonlinearity hysteresis time varying characteristics cause difficulties modeling behavior designing high performance controllers generalized three element model pam proposed obtain reference model reference mode given small pressure range equivalent state space representation reference model obtained applying linearization approach model error introduced equivalent state space model joint estimation adopted estimate system state model error simultaneously experimental studies conducted demonstrate existence model error verify necessity introducing model error reference model evaluate effect proposed active modeling approach changing modes given pressure range
autism spectrum disorders asd schizophrenia spectrum disorders ssd share clinical genetic components long recognized two disorders occur frequently would predicted respective prevalence suggesting complex multifactor association involved however dsm maintains distinction asd core social communication impairments ssd including schizophrenia scz hallucinations delusions thought disorder essential features asd ssd common biological underpinnings may emerge early development unfold time one hypotheses supporting similarities social cognitive disturbances asd ssd relates abnormalities ratio excitatory inhibitory cortical activity imbalance imbalance neurodevelopmental disorders could consequence abnormalities genes coding glutamatergic gabaergic receptors synaptic proteins followed system derangements ssd asd characterized polygenic disorders onset progression disease triggered interactions among multiple genes mammalian target rapamycin signaling intense investigation convergent altered pathway two spectrum disorders current understanding shared divergent patterns asd ssd molecular clinical aspects still incomplete may implemented research domain criteria approach
study objectiveto evaluate time achieve therapeutic activated partial thromboplastin time aptt values occurrence bleeding based standard unfractionated heparin ufh weight based dosing recommendations compared aggressive weight based ufh dosing strategy using higher maximum doses infusion rates obese nonobese patients presented non segment elevation myocardial infarction unstable angina nstemi atrial fibrillation designretrospective cohort study settingacademic medical center patientsa total adults included admitted nstemi atrial fibrillation cardiac indications received least hours continuous ufh infusion patients treated standard ufh dosing unit bolus maximum units followed infusion units hour maximum units september february patients received aggressive ufh dosing strategy unit bolus maximum units followed infusion units maximum units october march patients standard dosing aggressive strategy cohorts classified body mass index status normal overweight obese morbidly obese weight status measurements main resultsa time event analysis achievement therapeutic aptt range sec assessed significantly higher proportion patients treated aggressive strategy achieved therapeutic aptt within hours delay failure achieve therapeutic anticoagulation particularly evident obese patients standard dosing group mean initial infusion rate units hour standard dosing group versus units hour aggressive strategy group occurrence supratherapeutic aptt values highest aptt achieved similar two dosing groups respectively bleeding events reported either group conclusionpatients higher ufh maximum bolus doses infusion rates achieved therapeutic anticoagulation rapidly without increased bleeding doses adjusted obese well nonobese patients however despite use higher doses patients achieved therapeutic aptt values within hours suggesting even higher bolus dose infusion rate may still warranted
glucosinolates gis constitute major group natural metabolites represented three major classes aliphatic indolic aromatic chemical structures previous work soluble proteins metabolites arabidopsis mutants deficient aliphatic myb indolic gis cypbb analyzed focus investigating changes level membrane proteins mutants analyses tandem mass tag tmt labeled peptides derived cypb myb relative wild type resulted identification proteins membrane proteins fold changes statistical analysis showed increased decreased cypb increased decreased myb shared protein changes mutants one protein increased eight decreased bioinformatics analysis changed proteins led discovery three cytochromes glucosinolate molecular network gmn cytochrome atg cytochrome atg probable cytochrome atg cypa cypb may play role hydroxyl indolic gis production addition flavone methyltransferase represents interesting finding likely participate methylation process hydroxyl indolic gis form methoxy indolic gis analysis also revealed additional new nodes gmn related stress defense activity transport photosynthesis translation processes gene expression protein levels found correlated cypb myb
several powerful trends contributing aging much world population especially economically developed countries mitigate negative effects rapidly ageing populations societies must act early plan welfare medical care residential arrangements senior citizens manpower associated training needed execute plans paper describes development ambient intelligent community care platform aiccp creates environment ambient intelligence use sensor network mobile agent technologies aiccp allows caregivers quickly accurately locate charges access update share critical treatment wellness data automatically archive records aiccp presented paper expected enable caregivers communities offer pervasive accurate context aware care services
originated aerospace area smart material structures research hotspot application engineering structural health monitoring within context civil engineering research high performance sensing units important one piezoelectric materials belonging smart ones polyvinylidene fluoride pvdf widely regarded property advantages low cost good mechanical abilities high sensibility corrosion resistance paper validation pvdf sensors sensing units bridge structural local monitoring wireless experimental systems pvdf sensor structural local monitoring bridge model beam built firstly based operating mechanism measurement circuit characteristics pvdf introduced secondly system framework pvdf sensor local monitoring proposed bridge model built wireless sensor kits developed finally bridge damage monitoring experiments done structural local health monitoring using pvdf sensors experimental results show pvdf sensor handle structural impact response monitoring damage detection civil engineering developed wireless sensor experimental system easily implemented use practical monitoring engineering
paper presents public health rationale multipurpose prevention technologies mpts sexual reproductive health srh based regional trends demographic srh indicators distils important lessons gleaned introduction contraceptive reproductive health products past several decades order inform development future introduction mpts srh principal results comparison current demographic public health regional data clearly revealed greatest confluence women srh concerns occurs sub saharan africa south west asia regional overlaps srh risks outcomes present strong rationale developing mpts designed simultaneously protect unintended pregnancy hiv stis information acceptability marketing operations research female condom emergency contraception pills intravaginal rings identified key product characteristics socio behavioral issues considered development introduction mpts product characteristics formulation duration action presence magnitude side effects prescription status counter prescribed provider type training user perspectives contributed varying degrees provider user bias subsequent uptake family planning methods underlying socio behavioral issues including risk perception ambivalence social costs also contributed demand use early identification target populations critical market shaping demand creation defining appropriate service delivery channels mpts ultimately knowledge attitudes perceptions practices users partners drive success failure product introduction conclusions mpts provide compelling response multiple reinforcing srh risks faced women key regions world specific product characteristics socio behavioral correlates must taken account early development process successful introduction new mpts require solid understanding socio behavioral correlates effective demand generation appropriate integration health service delivery systems quality counseling proper use active engagement public private sectors article based presentation product development workshop hiv multipurpose prevention technologies held arlington virginia february forms part special supplement antiviral research elsevier rights reserved
current research explores whether momentary changes power shift professional interview outcomes two experiments manipulated power asking applicants recall time lacked power prior writing job application letter experiment interviewed admission business schools experiment independent judges unaware applicants experimental condition even existence power manipulation significantly preferred written face face interview performance powerful applicants powerless experiments power neutral applicants experiment addition judges preference power primed applicants mediated perceptions applicant persuasiveness overall merely asking participants remember personal experience power dramatically affected impressions interviewers findings illustrate power far reaching effects potentially important implications understanding psychology job interviews elsevier inc rights reserved
hiv aids known risk factor development pulmonary tuberculosis ptb however association less clear hiv extrapulmonary tuberculosis eptb conducted systematic review determine association hiv eptb searched electronic databases medline embase relevant conference literature using defined search terms eptb hiv publications english studies reporting adjusted estimates included search criteria include restriction age geographic location study participants qualitative quantitative analyses including test heterogeneity performed sixteen studies cross sectional case control conducted included final analyses screening articles conference abstracts qualitative analysis showed heterogeneity study design study population characteristics along medium high risk bias majority studies individual studies showed increased odds eptb compared ptb among hiv infected individuals provide overall pooled estimate value high cross sectional studies association hiv eptb observed individual studies high heterogeneity risk bias studies highlight need well designed prospective cohort studies assess true risk eptb hiv infected patient population
examine relationship unemployment life satisfaction affective well depending family status within couples employment status one partner data collected using day reconstruction method show unemployment negatively related life satisfaction affective well living partnership strengthens loss life satisfaction men weakens women unemployment person partner associated smaller loss life satisfaction unemployed men larger loss women argue findings reflect large extent changes cognitive well closely related identity utility unemployed feeling identity appears affected traditional gender roles
contact system plasma protease cascade initiated factor xii fxii activates proinflammatory kallikrein kinin system procoagulant intrinsic coagulation pathway anionic surfaces induce fxii zymogen activation form proteolytically active fxiia bacterial surfaces also ability activate contact system proteins indicating important role host defense using cooperation inflammatory coagulation pathways recent research shown inorganic polyphosphate found platelets activates fxii vivo induce coagulation pathological thrombus formation experimental studies shown interference fxii provides thromboprotection without therapy associated increase bleeding renewing interest fxiia driven intrinsic pathway coagulation therapeutic target review summarizes contact system acts cross road inflammation coagulation innate immunity
currently limited supportive reliable commercial software packages gnss ins data processing shortage compatible gnss ins data processing software become bottleneck development position orientation systems pos survey mapping applications thus paper introduces gnss ins data processing software called cinertial recently developed china open definitions data format parameters algorithm design software described detail including realisation ins mechanisation kalman filtering backward smoothing developed software tested evaluated comparing mainstream commercial software processing field test datasets precise feasible comparison procedure proposed paper evaluate quality new pos software efficient convenient cost effective way procedure applied compare new software two well known commercial software packages processing airborne terrestrial datasets respectively results show new software achieve level accuracy current commercial software market reflects new progress pos development china
background aims autonomic nervous system imbalance associated metabolic diseases including diabetes glibenclamide antidiabetic drug acts stimulating insulin secretion pancreatic beta cells widely used treatment type diabetes since scarce data concerning autonomic nervous system activity diabetes aim work test whether glibenclamide improve autonomic nervous system activity muscarinic acetylcholine receptor function pre diabetic obese male rats methods pre diabetes induced treatment monosodium glutamate neonatal rats monosodium glutamate group treated glibenclamide body weight day weaning days age control group treated water body weight food intake lee index fasting glucose insulin levels homeostasis model assessment insulin resistance omeostasis model assessment beta cell function fat tissue accumulation measured vagus sympathetic nerve electrical activity recorded insulin secretion measured isolated islets challenged glucose acetylcholine selective muscarinic acetylcholine receptor antagonists radioimmunoassay technique results glibenclamide treatment prevented onset obesity diminished retroperitoneal epididymal fat pad tissues addition glibenclamide treatment also reduced parasympathetic activity glycemia monosodium glutamate treated rats insulinotropic effect unaltered cholinergic actions islets monosodium glutamate groups increased conclusion early glibenclamide treatment prevents monosodium glutamate induced obesity onset balancing autonomic nervous system activity
using thermoelectric elements harvest energy heat great interest last decade paper presents direct current direct current boost converter maximum power point tracking mppt scheme low input voltage thermoelectric energy harvesting applications zero current switch technique applied proposed mppt scheme theoretical analysis converter circuits explored derive equations parameters needed design boost converter simulations experiments carried verify theoretical analysis equations prototype designed converter built using discrete components low power microcontroller results show designed converter achieve high efficiency low input voltage experimental efficiency designed converter compared commercial converter solution shown designed converter higher efficiency commercial solution considered voltage range
background aim comparative study evaluate clinical radiological outcome open treatment acute anterior glenoid rim fractures analyze influencing factors complications patients methods study included patients average age years range years surgery mean period follow years range years average extent glenoid fracture involvement range three fixation techniques applied bioresorbable pins small fragment screws bioresorbable suture anchors results mean score values points absolute constant score points normalized constant score points rowe score points oxford shoulder score points simple shoulder test points shoulder pain disability index subjective shoulder value fixation technique show significant influence however multi fragment fractures associated significantly inferior absolute points normalized constant scores points subscapularis insufficiency internal rotation deficit found patients posttraumatic osteoarthritis occurred patients conclusion open fixation yielded good excellent shoulder function patients clinical outcome primarily depended underlying type fracture significantly inferior outcomes expected patients multi fragment fractures main complications subscapularis insufficiency posttraumatic osteoarthritis
introduction psoriasis chronic inflammatory skin disease autoimmune mechanism participates triggering accelerated keratopoiesis etiology unknown environmental factors trauma infections involved aim paper present correlation index severity psoriasis quality life patients psoriasis methods cross sectional study patients psoriasis older years old agreed participate study applied dermatology life quality index psoriasis severity index descriptive statistics measures central tendency dispersion correlation measures used results patients male female mean age years education bachelor degree housework occupation duration disease years psoriasis plaques occurred psoriasis severity index mild result impact quality life moderate effect difference degree involvement disease impact quality life correlation quality life degree psoriasis conclusion quality life independent degree disease patients psoriasis
purpose subclinical atherosclerosis defined endothelial dysfunction coronary calcification increased carotid intima media thickness related cardiovascular events independent blood pressure data showing possible relation low vitamin levels subclinical atherosclerosis study aimed find relation vitamin level intima media thickness presence atherosclerotic plaques materials methods fifteen male female subjects essential hypertension aged included study intima media thickness measured presence plaque evaluated real time mode ultrasonography mylab xvg esaote spa genoa italy using mhz linear probe serum parathormone measured chemiluminiscence immunoassay vitamin level radioimmunassay results eighty patients plaques seventy three patients severe vitamin deficiency defined level insufficiency vitamin levels similar plaque groups intima media thickness positively correlated age fasting glucose hemoglobin correlation intima media thickness vitamin level ldl conclusion find relation vitamin level andintima media thickness hypertensive subjects lack significance may due high prevalence vitamin deficiency
background social media become outlets patients voice opinions ask questions since suffering rosacea isolating experience disease poorly understood patients use social media expand knowledge condition objective understand rosacea patients online health information seeking habits obtain better insight educational needs methods ten percent posts online rosacea forum composed members posts discussing patient viewpoints concern selected stratified random sampling three hundred nine queries directly categorized patients seeking advice two investigators qualitatively analyzed results patients primarily sought advice treatments triggers diet skin care special presentations disease questions frequently pertained adverse effects efficacy target therapy posts respectively conclusion proactively providing reliable resources comprehensive explanations treatments triggers diet skin care could helpful reducing patients confusion rosacea enhancing rosacea patient physician relationships
uncertain systems actuated smart material based actuators systems exhibit hysteresis nonlinearities corresponding control becoming challenging task especially magnetostrictive actuators dominated asymmetric hystereses common approach overcoming hysteresis effect inverse compensation combining robust adaptive control focusing asymmetric hysteresis phenomenon asymmetric shifted prandtl ishlinskii aspi model inverse developed corresponding analytical expression inverse compensation error derived prescribed adaptive control method applied mitigate compensation error simultaneously guaranteeing global stability closed loop system prescribed transient steady state performance tracking error without knowledge system parameters effectiveness proposed control scheme validated magnetostrictive actuated platform elsevier ltd rights reserved
background increasing number options atrial fibrillation stroke prophylaxis several medication related factors consider study aimed gain better understanding preference factors influence patient decisions selecting stroke prophylaxis objective determine factors influence patient stroke prophylaxis decisions preferred therapeutic options methods questionnaire stroke prophylaxis medication options distributed participants risk preferences elicited ranking rating medication preference factor statements selecting least preferred treatment options results reduced stroke risk lowest risk intracranial haemorrhage ich highest median preference factor ranking iqr stroke reduction ich risk reducing stroke risk availability lab test assess drug effect availability antidote preference factors highest ratings apixaban preferred treatment option blinded drug name unblinded treatment least preferred option blinded unblinded conclusions reducing stroke risk limiting ich risk important medication factors participants high inter participant preference variability suggests importance including patient decision making selecting stroke prophylaxis
dna emerging smart material construct nanovehicles targeted drug delivery programmability watson crick base paring enables construction defined dynamic dna nanostructures almost arbitrary shape dna readily functionalized variety molecular modules applications dna nanostructures still infancy one high expectations deliver solutions targeted therapy nucleic acids however easily enter cells unassisted biological barriers harsh nucleolytic conditions human body must also overcome highlight recent strategies dna nanostructures drug delivery dna nanovehicles facilitate targeting crossing biological barriers light discuss future solutions challenges dna nanovehicles unravel great potential facilitate targeted drug delivery elsevier rights reserved
advantages nasal high flow oxygen therapy nhf include allowing talking also eating drinking therapy however effect nhf swallowing reflex remains unclear present study aimed assess effects nhf swallowing reflex nine healthy adult japanese male volunteers history dysphagia diseases may cause dysphagia stroke parkinson disease evaluated participants received one four levels nhf intervention control min oxygen nhf system nasal cannula swallowing induced administration bolus injection distilled water polyethylene catheter level oxygen flow primary end point latency period swallowing reflex bolus injection defined time start bolus injection onset electromyogram emg burst first swallow mean latency times swallowing reflex min nhf significantly shorter control conditions study demonstrates nhf may enhance swallowing function increasing levels nhf reducing latency reflex nhf may allow continuation oral intake without aspiration oxygen therapy
background various medical fields rely detailed anatomical knowledge distal radius current studies limited two dimensional analysis biased varying measurement locations aims generate shape models distal radius investigate variations shape generate assess morphometrics standardized cut planes test model classification accuracy methods local radiographic database screened scans intact radii data sets segmented surface models generated statistical shape models computed overall gender side separate shape variation assessed evaluating number modes anatomical landmarks assigned used define three standardized cross sectional cut planes perpendicular main axis cut planes generated mean shape models individual radius cut plane following morphometric parameters calculated compared maximum width depth perimeter area overall shape model utilized evaluate predictive value leave one cross validation gender side identification within study population results eighty six radii left female years included overall side gender specific statistical models successfully generated first mode explained overall variance left radii higher shape variance number modes female male compared right radii number modes female male standardized cut planes could defined using anatomical landmarks morphometric parameters decreased distal proximal male radii larger female radii significant side difference overall shape model combined median classification probability side gender conclusions statistical shape models distal radius generated using clinical data sets models used assess overall bone variance define analyze standardized cut planes identify gender unknown sample data highlight potential shape models assess anatomy anatomical variance human bones
self healing technology new field within material technology represents revolution materials engineering changing way materials behave incorporating self healing technology road design process potential transform road construction maintenance processes increasing lifespan roads eliminating need road maintenance decreasing unnecessary premature ageing asphalt pavements self healing asphalt reduce amount natural resources used maintain road networks decrease traffic disruption caused road maintenance processes decrease emissions road maintenance process increase road safety addition environmental savings self healing materials potential deliver significant cost savings road network maintenance across three main self healing technologies available asphalt pavement design nanoparticles induction heating rejuvenation chapter reviews three options outlines future development self healing asphalt technology
automotive field brake wire bbw systems electronically regulated actuators capable applying desired braking torque vehicle wheel specifically electrohydraulic technology widely used commercial vehicles offers good tradeoff terms size weight cost however control bbw actuators configuration challenging problem many reasons among critical dead zone due fluid reservoir input saturation limits electric motor moves pump paper complete control architecture accounting nonlinear behavior presented main components linear controller dead zone compensator antiwindup block designed cascade fashion configuration achieved equilibrium point guaranteed globally asymptotically stable overall system shows robust respect variations position pressure curve simulation experiments production prototype proposed show effectiveness proposed strategy
zonulin considered biomarker increased intestinal permeability elevated levels found celiac disease primary aim study examine association serum zonulin levels gastrointestinal symptoms secondarily zonulin levels anthropometric metabolic factors offspring participants malmo diet cancer cardiovascular cohort mdc invited anthropometric clinical examination fasting plasma glucose levels measured questionnaires lifestyle factors medical history completed along visual analog scale irritable bowel syndrome vas ibs zonulin levels measured serum elisa neither symptoms diseases influence zonulin levels higher zonulin levels associated higher waist circumference diastolic blood pressure glucose levels higher zonulin levels associated increased risk overweight obesity hyperlipidemia detect altered zonulin levels among individuals reporting symptoms diseases higher zonulin levels associated higher waist circumference diastolic blood pressure fasting glucose increased risk metabolic diseases
higher education understood essential enabling social mobility research policy centred access university recently attention turned journey social mobility costs long distance extreme social mobility journeys particularly require analysis paper examines journeys first family university students especially high status degree medicine interviews students australian medical school three themes discussed roots participants social mobility journeys sociocultural difference experienced negotiated within medical school participants think professional identities futures students described getting medical school hard way emphasised different backgrounds attitudes wealthier peers many felt like imposters using self deprecating language highlight lack fit privileged world medicine however language also reflected resistance middle class norms served create solidarity community origin importantly patients rather narratives loss students stories reflect tactical refinement self incorporation certain middle class attributes alongside appreciation worth difference brings new destination medical profession
backgroundrecent treatment advances greatly improved prognosis patients multiple myeloma however newer effective treatments intensive expensive use remains low particularly among black patients methodsin current study authors reviewed use patterns stem cell transplantation bortezomib using surveillance epidemiology end results seer medicare linked database resultsafter controlling overall health potential access barriers black patients found less likely undergo stem cell transplantation less likely treated bortezomib moreover authors found underuse treatments associated increase hazard ratio death among black patients conclusionseliminating health disparities current focus public policy highly complex illustrated results current study patients multiple myeloma treatment disparities completely explained potential access barriers additional factors structural barriers health care system individual decision making among black white patients must explored fully explain disparity cancer american cancer society patients multiple myeloma treatment disparities completely explained potential access barriers additional factors must explored fully explain disparity
shape memory polymer snip attracted lots attentions recently kind smart material thermally induced smps remember two different shapes combined functions polymer molecular architecture morphology specific multi step processing technology named shape memory creation programming paper aims analyze polyurethane shape memory properties based viscoelastic theory first polyurethane creep relaxation performances simulated using maxwell weichert model simulated results relaxation process found good agreement experimental results later model used describe polyurethane shape memory effects strain controlled situation results show polyurethane shape recovery ratios almost whereas shape fixing properties relatively poor moreover shown simulated results recovery time different recovery temperatures recovery time shortens along increase recovery temperature
higher mode vertical vortex induced vibrations viv observed several steel box girder suspension bridges different vertical modes selectively excited turn wind velocity accordance strouhal law understanding relationship viv amplitudes different modes vibration important wind resistant design long span box girder suspension bridges study basic rectangular cross section side ratio used investigate effect different modes viv amplitudes section model tests section model flexibly mounted wind tunnel variety spring constants simulating different modes vibration non dimensional vertical amplitudes determined function reduced velocity two lock ranges observed onset reduced velocities approximately cases second lock range induced conventional vortex shedding consistently gives larger responses first one normalized maximum non dimensional responses almost different spring constants first lock range vibration frequency approximately two times vortex shedding frequency probably result super harmonic resonance frequency demultiplication main conclusion drawn section model study central higher mode viv suspension bridges viv amplitude different modes provided number modes identical
recently growth interest novel skin care formulations containing active ingredients low molecular weight peptides paper present new skincare formulations hydrogels oil water emulsions water oil emulsion containing tetrapeptide acetyl pro pro tyr leu formulations characterized terms physicochemical parameters viscosity stability particle size distribution additionally diffusion parameters peptide obtained formulations calculated based einstein smoluchowski equation furthermore order determine penetration tetrapeptide membranes release kinetics investigated basis release curves release rate constants determined results proved properties formulations strongly determined release rate tetrapeptide higher viscosity semisolid slower permeation membrane elsevier rights reserved
hostile attribution bias tendency interpret intention others hostile ambiguous social contexts associated impulsive aggression adults results mixed complete sequence hostile inferential processes leading aggression investigated yet goal event related brain potentials erps study track neural activity associated violation expectations hostile versus nonhostile intentions aggressive nonaggressive individuals examine neural activity relates self reported hostile attributional bias impulsive aggression real life end scenarios hostile versus nonhostile social context followed character ambiguous aversive behavior presented readers erps critical words specified hostile versus nonhostile intent behind behavior analysed thirty seven aggressive fifty nonaggressive individuals participated study presentation critical word violated hostile expectation caused response significantly larger aggressive nonaggressive individuals results also showed enhanced late positive potential like component aggressive individuals hostile intention scenarios took place nonhostile context associated impulsive aggression real life even controlled effect self reported hostile attributional bias hostile expectancy violation paradigm evaluated study represents promising tool investigate relationship online processing hostile intent others impulsive aggression aggr behav wiley periodicals inc
eyewitness reports become less accurate exposure inconsistent information phenomenon diminishing accuracy occurs among cowitnesses termed memory conformity social contagion effect present study set provide rigorous test underlying mechanisms particular emphasis investigating whether genuine false memory involved end conducted earwitness experiment participants exposed discrepant cowitness information provided recollections repeatedly different conditions additionally examined impact cowitness intimacy using random assignment procedure aspect previously studied regard underlying processes findings clearly argue informational rather normative influence plays dominant role moreover highly accurate source attributions indicated participants aware drawing recollection counterparts consequently obtain evidence false memory regard cowitness intimacy results inconsistent call research
type functional variable method used private type nonlinear fractional differential equations main property method demonstrate flexibility ability solve nonlinear equations accurately efficiency conveniently fractional derivatives described modified riemann liouville sense three examples presented show application present technique result periodic hyperbolic solutions obtained
purpose study develop health work survey insat examine validity discomfort rating scale data collected portuguese workers six economic sectors support health work survey insat inquerito saude trabalho insat self administered questionnaire assessing working conditions health wellbeing provide information occupational health systems organisations survey instrument validation rasch partial credit model pcm used analyse item fit statistics application pcm person separation reliability obtained value considered good statistical analysis overall model fit information given outfit mean square infit mean square meaning productive measurement acceptable fit overall insat items generate predictable response patterns recommend insat discomfort rating scale items reviewed future works event tool proves useful assessing relationship work health evaluating key main risk factors helping prevent problems improving occupational health systems
paper presents novel hybrid ant colony optimization approach aco vns solve permutation flow shop scheduling problem pfs manufacturing systems industrial process main feature hybrid algorithm hybridize solution construction mechanism ant colony optimization aco variable neighborhood search vns also embedded aco algorithm neighborhood search improve solutions moreover hybrid algorithm considers solution diversification solution quality finally experimental results benchmark pfs instances shown hybrid algorithm efficient solve permutation flow shop scheduling manufacturing engineering compared best existing methods terms solution quality
paper concerned existence result periodic solutions class fourth order ordinary differential equations involving extended fisher kolmogorov swift hohenberg equations suitable growth condition nonlinear term one proves existence result applying mawhin continuation theorem elsevier ltd rights reserved
nowadays manufacturing facing critical challenges various aspects including trend moving towards new era industrial analytical predictive driven production thinking smart factory effectively embed necessary processes analytics new way modeling process flows essential realize goal predictive lean production reach objectives paper presents novel process modeling approach analytics vital practitioners industries analysis smart factory theme includes statistics data mining operation research approaches based various management improvements prediction objectives proposed process modeling analytics extends xml extensible markup language also commonly used software engineering purpose using streamline latter integration analytical processes among software systems play key part factory knowledge management continuous optimization
big data potential research area receiving considerable attention academia communities digital world amounts data generated stored expanded within short period time consequently fast growing rate data created many challenges paper use structuralism functionalism paradigms analyze origins big data applications current trends paper presents comprehensive discussion state art big data technologies based batch stream data processing moreover strengths weaknesses technologies analyzed study also discusses big data analytics techniques processing methods reported case studies different vendors several open research challenges opportunities brought big data similarities differences techniques technologies based important parameters also investigated emerging technologies recommended solution big data problems elsevier ltd rights reserved
parabolic current control attractive current control method fast transient response constant switching frequency due good dynamics parabolic current control employed voltage source inverters improve system performance minimizing distortion current waveforms voltage waveforms implement parabolic current control current sensor required associated current conditioning circuit parabolic carrier generators since parabolic current control based real time information inductor current phase delay propagation delay sensor conditioning circuitry limited resolution parabolic carrier generators could impact current control performance since parabolic current control compares analog signals generate required control signals noise control board impacts control precision well paper explore solutions problems first inductor current voltage source inverter analyzed parabolic current control strategy studied sensorless parabolic current control method proposed new sensorless parabolic control method utilizes current emulator rebuild inductor current microcontroller avoid offset side output voltage caused current emulator additional control loop current emulator added effectiveness proposed methods experimentally verified use bridge voltage source inverter
objectivethe pathogenesis borderline personality disorder bpd well understood examined microstructure white matter patients bpd methodtreatment naive young adult bpd young adult healthy controls hcs subjected diffusion tensor imaging dti microstructural parameters analyzed via tract based spatial statistics tbss post hoc tractography resultstbss analysis revealed relative group bpd group significantly lower fractional anisotropy values genu body corpus callosum right superior corona radiate right anterior corona radiate well higher radial diffusivity left anterior thalamic radiation tractography showed values fiber bundles passing fornix significantly reduced bpd group relative hcs significant correlations observed clinical symptom dti indices bpd group fdr corrected conclusionfocal microstructural alterations found bpd group mainly limbic system present findings support fronto limbic disconnectivity hypothesis suggest abnormal maturation white matter structures may play important role mechanism bpd
violent behaviors cause concern among people policy makers politicians educators social workers parents associations etc different fields perspectives measures taken try solve problem violence institutional communication campaigns violence publication news related violent events often actions used policy makers literature data shown effectiveness always exactly expected even anti violence messages opposite effect reinforce attitudes thought violence necessary hypothesis people assume problem core message anti violence campaigns key issue problematic individuals likely violent precisely address communications could react anti violence message violent way tragic paradox anti violence message could increase predisposition violent behavior would case literature called boomerang effect article highlights need detailed empirical studies certain effects media desensitization imitation accessibility reactance could help explain emergence boomerang effect
study objective aimed determine prevalence contraceptive methods identify factors associated use contraception greek female higher education students design cross sectional epidemiologic survey factors determining use contraception among higher educational students subject female students years age main outcome measures used primary individualized data drawn survey carried among female college students greece dependent dichotomous variables responses yes question last months contraceptive method generally used sexual intercourses methods male condoms oral contraceptive use ocs emergency contraception independent variables analysed survey socio demographic characteristics variables related lifestyle variables associated sexual habits results condom widely used variables associated independently significantly greater likelihood use condoms condom use first sexual intercourse occupational status higher educational level parents ocs relationship sexual lifetime partners ever visited gynecologist likely use use older relationship smokers sexual lifetime partners likely use method conclusions condom used contraceptive method among female higher educational students greece followed variable strongly associated use ocs gynecologist visit factors associated use sexual partners smoking stable sexual partner
phylogenetic analysis achieved extraordinary results domains like species delimitation evolutionary biology essential element behind success introduction high performance computing techniques step estimating phylogenetic likelihoods paper describes design implementation distributed cpu gpu based heterogeneous computing system parallelizing analysis parallelization implemented state art version mrbayes widespread phylogeny reconstruction program benchmarked method another two gpu based methods using distributed computing nodes tianhe experimental results indicate proposed method outstrips beagle nmc method speedup factors respectively comparison serially implemented mrbayes peak speedup finally achieved using tesla gpus proposed method publicly available facilitate research phylogenetic analysis
purpose reviewrunner diarrhea acute exercise induced diarrhea usually pathological situation affect performance review focuses discussion main causes runner diarrhea nutritional recommendations prevent recent findingsalthough based limited data multiple transportable carbohydrate intake exercise instead glucose alone recommended preventing urge defecate possibly diarrhea additionally avoiding ingestion fermentable oligosaccharides disaccharides monosaccharides polyols fodmaps related lower incidence reported gastrointestinal problems however still study associates fodmaps runner diarrhea gluten free diets seem impact exercise induced intestinal damage evidence recommend diet prevention diarrhea nonceliac athletes summarythe main causes diarrhea runners ischemic mechanical nutritional factors prevention diarrhea recommended dehydration ingestion fiber fat protein high concentrated carbohydrate beverages fodmaps caffeine bicarbonate nonsteroidal anti inflammatory drugs avoided however causes diarrhea nutritional strategies prevent based limited research studies definitely needed
paper design testing interfaced pic based control unit used manage absorption spectrophotometer employing white led light source described led technology allows perform absorption measurements reducing analyte temperature variations thus noise generation occur xenon light source usually employed used also thanks led technology system results low cost easy use low power consumption realized spectrophotometer used atmospheric industrial pollutant detection indoor air monitoring hospital rooms able detect particulate matter pesticides volatile organic compounds well pollution produced heavy metals realized system manages different required functionalities acquisition processing via firmware raw data provided sensors actuation mechanical devices stepper motor solenoid valve synchronizing controlling data exchange hardware sections microcontroller hardware software sections designed carrying appropriate tests verify proper operation results confirm correct system functioning interaction via terminal user realized control unit
hoc networks subject multiple challenges particularly problem limited resources energy vulnerability terms security indeed nodes subject various attacks malicious actions thus mobile confronted dilemma cooperate ensure security case node spend part energy cooperate allows save energy making security network vulnerable work develop approach takes account two conflicting objectives contribute network security reducing energy consumption approach based alternating two steps clustering evolutionary game clustering step performed algorithm takes account energy constraint election cluster heads interactions pair cluster heads exchanging data contribution security network modeled evolutionary game second step proposed approach
countries still suffering problems excessive fluoride containing water greater fluoride groundwater reported villages china order meet challenge drinking water defluoridation engineering high efficiency affinity defluoridation adsorbent ppy tio composite designed synthetized situ chemical oxidative polymerization fourier transform infrared spectroscopy ftir ray diffraction investigator xrd ray photoelectron spectroscopy xps thermogravimetric analysis isotherm analysis scanning electron microscopy sem zeta potential analysis conducted characterize surface textural properties prepared ppy tio possibility fluoride adsorption carefully estimated adsorption isotherm kinetic studies characterization investigations demonstrate uniqueness surface textural properties suitable specific surface area abundant positively charged nitrogen atoms indicate composite suitable material fluoride adsorption adsorption isotherms kinetics follow better langmuir pseudo second order model respectively maximum adsorption capacity reaches degrees according langmuir model particular interest ability reduce concentration fluoride drinking water within min moreover adsorbent easily recycled without loss adsorption capacity six cycles greatly highlighting outstanding affinity fluoride low cost novel used purification fluoride containing water drinking furthermore adsorption mechanism extensively investigated discussed ftir investigation batch adsorption studies including effect surface potential thermodynamics adsorption confirmed spontaneous exothermic process decreasing entropy prominently conducted electrostatic attraction ionic exchange chelation may also involved hydroxyls positively charged nitrogen atoms play important roles adsorption elsevier inc rights reserved
work attempts reduce component count low high pass active filters also uses lower order filter achieve results higher order ones terms frequency response optimizers used nelder mead pso filters transformed small signal analysis nodal analysis used translate circuit matrix form three different examples presented illustrate effectiveness approach results revealed computer program lower order operational amplifier filter used achieve results higher order one also pso achieve best results regard frequency response three examples followed nelder mead worst result
hypothesis changes weather influence symptom severity meniere disease background unpredictable condition significantly impacts quality life suggested fluctuations weather especially atmospheric pressure may influence symptoms however date limited research investigated impact weather methods longitudinal study mobile phone application collected data individuals females males average age reporting consultant diagnosed daily symptoms vertigo aural fullness tinnitus hearing loss attack prevalence gps locations collected data linked met office weather data including atmospheric pressure humidity temperature visibility wind speed results symptom severity attack prevalence reduced days atmospheric pressure higher atmospheric pressure hectopascals risk attack confidence interval humidity risk attack confidence interval conclusion study provides strongest evidence date changes atmospheric pressure humidity associated symptom exacerbation improving understanding role weather environmental triggers meniere may reduce uncertainty associated living condition significantly contributing improved quality life
prospective memory refers ability remember execute future intentions taking medication dinner although prior research prospective memory errors focused omission errors failures perform intention response target cue recent surge research commission errors erroneous performance finished intention existing studies examined factors retrieval lead commission errors present study extends research investigating impact encoding strength found relative standard encoding implementation intention encoding doubled risk commission errors laboratory paradigm young older adults novel finding demonstrates impact encoding strength commission errors documents potential challenges deactivating effects implementation intentions upon completion prospective memory task
electric power consumption sanitation companies represents second largest operating cost item explained many electric motors operate facilities electric motor electric device capable transforming electrical energy mechanical energy devices responsible electricity consumed world machines fail consequently repairs needed many companies choose outsource repair service broken electric motors capital cities many suppliers selecting classifying suppliers groups fulfill strategic goals significant challenge paper presents model classify businesses provide electric motor repair services model used pre qualify suppliers end promsort multicriteria classification method applied classify suppliers non compensatory way according evaluation criteria applied method enabled classification evaluated companies four groups based attributes related facilities professionals experience results showed model effective application applied contexts also related classification problem
following recent rapid development researches utilizing magnetorheological fluid smart material magnetically controlled change apparent viscosity instantaneously lot applications established exploit benefits advantages using fluid one important applications fluid devices valve uses popular flow valve mode among available working modes fluid valve widely applied lot hydraulic actuation vibration reduction devices among dampers actuators shock absorbers paper presents review valve discusses several design configurations mathematical modeling valve therefore review paper classifies valve based coil configuration geometrical arrangement valve focusing four different mathematical models valve bingham plastic herschel bulkley viscous herschel bulkley pre yield viscosity hbpv models calculating yield stress pressure drop valve design challenges opportunities application fluid valve also highlighted review hopefully review paper provide basic knowledge design modeling valve complementing reviews fluid applications technologies
purpose study determine impact unofficial pocket payments satisfaction education countries former soviet union mongolia linear indicates pocket payments weaken satisfaction factor biprobit indicates pocket payments lessen satisfaction percentage points time interaction model demonstrates negative impact paying unofficial pocket payments declines quality education improves quality education deteriorates negative impact paying unofficial pocket payments grows considerably authors published elsevier ltd
approval new drugs increasingly reliant surrogate endpoints correlate imperfectly predict clinical benefits proponents argue surrogate endpoints allow faster approval critics charge provide inadequate evidence develop economic framework addresses value improvement predictive power quality surrogate endpoints clarifies quality influence decisions regulators payers manufacturers example framework shows lower quality surrogates lead greater misalignment incentives payers regulators resulting drugs approved use covered payers efficient price negotiation marketplace help align payer incentives granting access based surrogates higher quality surrogates increase manufacturer profits social surplus early access new drugs since return better quality shared manufacturers payers private incentives invest higher quality surrogates inefficiently low author published elsevier
living beings programmed death due aging age related processes aging normal process every living species cells inevitably progressing towards death many disease processes accelerate aging process leading senescence pathologies alzheimer disease parkinson disease multiple sclerosis amyotrophic lateral sclerosis huntington disease cardiovascular disease cancer skin diseases associated deregulated aging healthy aging delay onset age related diseases genetics epigenetics reported play large roles accelerating delaying onset age related diseases cellular mechanisms aging age related diseases completely understood however recent molecular biology discoveries revealed micrornas mirnas potential sensors aging cellular senescence due mirnas capability bind untranslated region utr mrna specific genes mirnas prevent translation specific genes purpose article highlight recent advancements mirnas involvement cellular changes aging senescence article discusses current understanding cellular senescence interplay mirnas regulation contribute disease processes elsevier rights reserved
background fragile associated tremor ataxia syndrome adult onset disorder associated premutation alleles fmr gene disorder characterized progressive action tremor gait ataxia cognitive decline fragile associated tremor ataxia syndrome pathology includes dystrophic white matter intranuclear inclusions neurons astrocytes previously demonstrated transport iron brain altered fragile associated tremor ataxia syndrome therefore also expect alteration iron metabolism brain areas related motor control iron essential cell metabolism uncomplexed iron leads oxidative stress contributes development neurodegenerative diseases investigated potential iron modification putamen structure participates motor learning performance fragile associated tremor ataxia syndrome methods used samples putamen obtained fragile associated tremor ataxia syndrome control cases study iron localization using perl method iron binding proteins using immunostaining results found increased iron deposition neuronal glial cells putamen fragile associated tremor ataxia syndrome also found generalized decrease amount iron binding proteins transferrin ceruloplasmin decreased number neurons glial cells contained ceruloplasmin however found increased levels iron transferrin ceruloplasmin microglial cells indicating attempt immune system remove excess iron conclusions overall found deficit proteins eliminate extra iron cells concomitant increase deposit cellular iron putamen fragile associated tremor ataxia syndrome international parkinson movement disorder society
software cybernetics aims improving reliability software introducing control theory software engineering domain systematically key issue software verification improve reliability software inspecting whether software achieve expected behaviors paper thought software cybernetics applied process verification address issue nested control system established proposed method verifies functional requirements dynamic environment constantly changing user requirements program serves controlled object verification strategy determined software behavioral model sbm serves controller main contribution paper includes sbm established software design phase concern based construction approach proposed starts obtaining software expected functionality extracted requirement text program abstract relationship model parm constructed basing process gradual abstract controlled object feedback form intermediate code generated process verification proposed method validated case study elsevier inc rights reserved
prostate specific antigen psa era prevalence male stress urinary incontinence sui continues rise prostatectomies performed treatment male sui multifactorial decision depending bladder sphincteric function also patient choice due economic burden strain quality life procedures devices developed help patients alleviate symptoms mainstays treatment include conservative management biofeedback kegel exercises periurethral bulking agents surgical procedures male urethral sling artificial urinary sphincter proper evaluation important bladder dysfunction form detrusor overactivity detrusor underactivity poor bladder compliance occur independently coexist intrinsic sphincter deficiency thus important clearly define patient symptomatology optimize outcomes
aim study determine wearing wrist guard snowsports impacted fracture site wrist participants presenting two australian resort medical centres wrist fractures one month peak season invited participate differences mean distance ratio fracture site wrist determined guard wearing non guard wearing populations using analysis variance mean distance wrist fracture sites forearm wrist joint times radius diameter individuals reported using guards non guard wearers times radius diameter significant difference found distance fracture wrist joint two groups authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
globalization brings new cultural experiences choices people choose musical culinary literary activities cultures also choose experiences mix cultures together propose preference culturally mixed experiences hinges preconceptions cultural differences diversity ideologies namely colorblindness multiculturalism polyculturalism study measured participants endorsement three diversity ideologies preferences culturally unitary versus mixed experiences results showed polyculturalism mindset cultures interact contribute positively associated liking culturally mixed experiences study experimentally induced three mindsets found polycultural mindset heightened preferences culturally mixed experiences study replicated positive effect polyculturalism preference cultural mixes kinds mixes effect polyculturalism people choice cultural mixes mediated purity concerns discuss implications psychology globalization elsevier inc rights reserved
front end planning arguably impactful activity management construction projects small projects oftentimes minimal planning completed prior start design construction much detriment project success paper summarizes research efforts develop front end planning tool specifically small projects namely project definition rating index small industrial projects pdri sip set specific elements relevant planning sips developed five separate workshops held industry professionals evaluated prioritized proposed elements tool validated completed ongoing sips statistical analysis showed projects better scope definition significantly improved cost schedule performance projects lesser scope definition comparison front end planning practices small large industrial projects showed planning project execution project feasibility significantly important small projects paper contributes body knowledge detailing development novel front end planning tool designed use prevalent project type industrial construction sector depth analysis front end planning practices small large industrial construction projects american society civil engineers
paper presents review current denial service dos attack defence concepts theoretical practical point view seriousness dos attacks tangible present one significant threats assurance dependable secure information systems growing importance rapid development new increasingly sophisticated attacks requires resourcefulness designing implementing reliable defences focus providing fresh relevant state art reference included different perspectives economicdos edos offensive countermeasures cyber space considering elaborated dos mechanisms state art review considerations main challenges discussed directions proposed future research considered required defending dos threat evolving potentially major disruptive factor global security models levels
deterioration highway system received significant attention scholars industry practitioners policymakers last several decades growing interest encouraged production multiple reports highlighting challenges enhancing system conditions long term government agencies sufficient resources take care roads timely manner deterioration worsens available funds primarily used previously deferred maintenance rehabilitation activities current work seeks gain insight dynamics capital investments maintenance expenditures road infrastructure based system dynamics model authors argue highway system stuck capability trap failure achieve sustained improvements authorities tend promote short term reactive efforts long term proactive actions study contributes existing literature highlighting feedback mechanisms connect maintenance rehabilitation expenditures aging deterioration processes building counterfactual analysis research reveals incentivizing preventive practices enhances system conditions also reduces major rehabilitation expenses long term frees resources capacity expansion conclusions point difficulties associated escaping trap impacts implementing reactive proactive policies throughout highway system american society civil engineers
solar energy universally accepted potential alternative power source due inexhaustible availability diverse conversion technology environmental friendly nature hybrid photovoltaic thermal system optimized solar energy system produces electricity thermal energy simultaneously physical profile basic problem hybrid collector removal transfer heat efficient way article system novel design thermal collector excluding absorber plate introduced resolve mentioned problem parallel plate thermal collector without absorber plate attached directly module backside means thermal paste performance evaluated numerically validated experimental data different operating conditions numerical analysis system performed using finite element method fem based software comsol multiphysics outdoor experimental investigation done typical climatic condition malaysia elevation head water employed ensure passive cooling module numerical simulation results found well agreement experimental measurements thermal performance without absorber plate found almost good absorber plate numerical experimental values maximum overall efficiency system found respectively irradiation level inlet ambient temperatures degrees developed simulation model extended designs thermal collector using different materials published elsevier ltd
paper presents original approach designing analog signal processing circuits based using functional core implementing multitude circuit functions signal gain theoretical null distortions signal squaring voltage multiplying good linearity simulation perfect linear resistor positive negative equivalent resistance great advantages increased modularity controllability reduced design costs represent immediate consequence multiple functions realized proposed structures important circuit complexity concentrated implementing core multifunctional structure circuit area power consumption per realized function strongly reduced using method especially multifunctional structures able implement important number functions proposed circuits designed low voltage low power operation supplied consuming depending implemented function
recent advancements machine learning algorithms transformed data analytics domain provided innovative solutions inherently difficult problems however training models scale large data sets remains daunting challenge one problem detection overlapping communities within graphs example social network modeled graph vertices edges represent individuals relationships opposed problem graph partitioning clustering individual part multiple communities significantly increases problem complexity paper present evaluate efficient parallel distributed implementation stochastic gradient markov chain monte carlo algorithm solves overlapping community detection problem show algorithm scale process graphs consisting billions edges tens millions vertices compute cluster nodes best knowledge first time problem deducing overlapping communities learned problems large scale
harmonising metadata format alone solve issue efficient access relevant information heterogeneous environments different systems use different content contextual semantic concepts certain entities one type heterogeneous systems also current research information systems cris store data primarily local relational databases using different formats various local concepts article study possibilities propose new ontologically supported semantic search engine ossse addition harmonisation metadata format among local cris systems also ensures meaning data concepts belong various metadata entities also harmonised special model ontological infrastructure designed dedicated test ontology created alongside new simplified algorithm creating ontology basis distinction new already existing classes terms content finally evaluated proposed ossse model using simulation search process base real searches within sicris obtained results show regardless search situation proposed ossse always least efficient search without ontological support terms precision recall remains improvement shown statistically significant high confidence interval proposed ossse model able solve issue harmonizing data different heterogeneous systems use different content contextual semantic concepts case many advanced expert systems manner search carried based properties described supporting ontology infrastructure help searcher proposed concepts ontological infrastructure designed semantic search engine may well help improve search precision several information retrieval systems elsevier ltd rights reserved
enterprise network security solution optimization complex challenging problem given large number components involved paper describes project ultimate goal providing optimized solutions enterprise network security describe approach implementing optimized security assessment using genetic algorithm dynamic nature enterprise network security analysis tools devised network need function dynamic mode well incorporated fuzzy logic controller flc fine tune optimization algorithm run time flc takes consideration exploration exploitation aspect calculates appropriate adjustments control parameters selection crossover rate possible attack paths identified evaluated based attack graph representing network study attack paths satisfy certain optimization criteria selected presented possible components security solution also carried comparative study performance adaptive used problem conventional results shows attack graphs analyzed adaptive yields significantly better solutions
backgroundonychomycosis principally caused dermatophyte species nondermatophyte molds yeasts also involved causing different clinical manifestations aim investigation determine clinicomycological epidemiological profile etiologic agents onychomycosis methodsthe study population included suspected cases onychomycosis referred medical mycology reference laboratory isfahan iran nail clipping collected sterile petri dishes direct microscopic examination culture clinical isolates identified using phenotypic tests molecular techniques resultsof total cases clinical suspicion onychomycosis comprised present study patients positive direct microscopy age range patients years housewives commonest infected population candida albicans prevalent species isolated patients study followed trichophyton interdigitale aspergillus flavus conclusionthe pattern causative agents clinical signs onychomycosis altering region region repeated epidemiological surveys onychomycosis seems fundamental present study provides novel appropriate epidemiologic data onychomycosis better prevention treatment fungal infection
thought provoking experimental evidence suggests perinatal light exposure may imprint circadian clocks lasting effects alignment stability circadian rhythms later life assuming exposure light early life could determine stability individual circadian system later life present hypothesis proposes time year location birth season latitude thus differential zeitgeber strengths may key contributors person susceptibility developing mood disorders like seasonal affective disorder sad common internal cancers breast prostate consequently people born might critically predispose mood disorders internal cancers may affect onset course illnesses paper develops causal framework presents suggestions rigorous tests associated corollary predictions escape attention links perinatal zeitgeber strength light effects stability circadian systems later life could role play affecting long term health beyond cancer mood disorders mostly adults also children
investigation letter dimensional generalized breaking soliton equation describes dimensional interaction riemann wave propagating along axis long wave along axis singularity analysis carried shown generalized equation admits painleve property one set parametric choices integrable properties corresponding pain leve integrable equation bilinear form soliton solution bilinear backlund transformation lax pair infinite conservation laws derived binary bell polynomials elsevier ltd rights reserved
engineering whether form product development manufacturing processes often drives selection creation new materials order meet performance requirements conversely development new materials new ways process materials lead new engineering capabilities turn lead new products improved product performance interplay materials engineering dynamic ongoing critical success many new products industries article take examples interplay four technology companies different industries developing widely different materials systems example demonstrates critical role materials play creating new products new manufacturing methods even new design methodologies examples come polymer microfluidic devices silicon nonsilicon based microelectromechanical systems metals additive manufacturing
gas sensors play vital role many aspects society gained much progress propelled development nanoscience nanotechnology regard metal oxides heterojunctions attracted tremendous attention owing enhanced gas sensing properties herein belt tooth shape zno ino nano heterostructures achieved chemical vapor deposition process gas sensor fabricated prepared nano heterostructures exhibits superior sensing performances gas low operating temperature degrees moreover decorated zno ino nano heterostructures zno ino exhibit enhanced sensing properties higher response less response time better selectivity smaller deviation ideal value power exponent significantly response gas maintained well days indicating good long term stability addition potential barrier controlled carrier transport model combining surface depletion model unique properties presented describe gas sensing mechanism zno ino study offers innovative methodology design novel gas sensing materials enhance gas sensing performances elsevier rights reserved
background congenital hypothyroidism common endocrine disease important cause mental retardation purpose study investigate probable role season climatic factors incidence kerman province iran methods incidence data collected screening program files kerman province number infants included study climate data collected meteorological office relations tested chi test pearson correlation negative binomial regression results overall incidence kerman province per births significant difference monthly seasonal incidence significant weak correlation climatic factors incidence regions results inconsistent conclusions seems like clear relation incidence climate factors kerman province however incidence highest october autumn lowest june summer
mechanical vibrations therapy widely used non conservative safe physical method patients diagnosed osteoporosis postmenopausal women sportsmen training also athletes recovery rehabilitation phase paper main goal assessing benefic effects whole body vibration wbv therapy applied professional sportsmen complementary alternative training improve sport performance quality life experiment applied group ten volunteers athletes university ages years appropriate weight height signed statement self agreement participate study wbv trial performed via proper dynamic vibration installation two months subjects sitting bed upper limbs thighs inferior limbs extended provide support spine fixed support installation comprised vibration bed direct control vibration signal electronic analyzing system acquisition interpretation vibration data allowing automat control rotation frequency alarm safety system visualization line measurement process electric motor vibrating bed generate predictable vibration values three axes used two types tri axial vibration sensors one accelerometer fixed bed second implant accelerometer anterior face thigh evaluated subject mechanical vibration training session performed frequency minutes consisted eight series seconds one minute breaks evaluation data made assessing values subjects recorded initial stage final therapy supposed control objective parameters standing long jump standing high jump intensity exercise performed physical efforts results vibration trial stressed subjects significant increase sport performances vibration training parameter assessing means wbv viable alternative method used sportsmen improve athletic performance quality life
paper suggest hierarchical control scheme applicable engine control chosen setup facilitates simultaneous control emissions torque top level standard pid controller installed setting injection quantity order reach demand torque prerequisite follow given load profile second level dedicated emission control apply dynamic matrix control dmc specific form model predictive control dmc stands simple way modeling controlled process represented step responses constraints absolute values maximum rates change applied manipulable system inputs cope given hardware limitations moreover incorporate called operational constraints thus constraining input variables certain polytopic operating regions thereby areas high emissions excluded advance furthermore include predefined demand torque input dmc known impact transient torque changes emissions dmc act optimal way respect given load profile cope nonlinearities combustion engine apply network several dmcs scheduled engine speed load well manipulable actuators also propose procedure reduce amount modeling data introducing parameterized formulation measured step responses proposed control concept evaluated realistic physically based engine model several representative driving sequences amongst well known new european driving cycle nedc highly dynamic worldwide harmonized light duty test cycle wltc advantages dmc conventional pid control finally summarized demonstrated typical load step
article presents strength analysis toroidal pressure tank using fem purpose analysis estimation proposed models respection time arrangements fem mesh realization calculation toroidal lpg tank subject research
cigarette smoking regulates innate adaptive immunity causes numerous diseases including cardiovascular respiratory autoimmune diseases allergies cancers transplant rejection therefore smoking poses serious challenge healthcare system worldwide epidemiological studies always shown one major risk factors transplant rejection even though smoking plays redundant roles regulating immune responses complex roles smoking immunoregulation likely due molecular functional diversities cigarette smoke components including carbon monoxide nicotine especially shown induce immune tolerance although shown impact transplantation causing complications subsequent rejection overlooked whether interferes transplant tolerance previously demonstrated cigarette smoke exposure reverses long term allograft survival induced costimulatory blockade given impacts adaptive innate immunity hinders long term transplant survival perspective impacts transplant tolerance review impacts major immune cells critical transplant outcomes propose cellular molecular mechanisms underlying effects alloimmunity transplant survival investigations warranted fully understand exerts deleterious rather beneficial effects transplant survival even components immunosuppressive
aimthis study determined effect physician champions two main components kangaroo mother care kmc skin skin care breastfeeding methodskmc practices among retrospective cohort infants admitted rural indian neonatal intensive care unit nicu january october studied kmc champions identified based performance evaluation examined effect withdrawing physician champions overall use time initiation intensity skin skin care breastfeeding using separate models resultsin comparison kmc champions present absence associated decrease odds receiving skin skin care confidence interval decrease rate initiation skin skin care average less hours skin skin care breastfeeding practices similar across different champion environments conclusionwithdrawing physician champions nicu setting associated decline skin skin care breastfeeding training health care workers community stakeholders become champions could help scale maintain kmc practices
paper presents experimental study laboratory tests conducted investigate different interlayers pavement surface slabs bases could improve performances vibration response anti erosion bases tests vibration response bases geotextile rubber sheet used interlayers micro seismic testing system employed characterize vibration response bases concrete pavements beneath different interlayers impact loading vibration test results indicated impact loading compared bases without interlayer atop vector sum maximum vibration velocity bases beneath rubber sheet interlayer two layers geotextile interlayer decreased respectively vector sum maximum vibration displacement decreased respectively laboratory tests anti erosion bases geotextile emulsified asphalt slurry seal interlayer atop tested performances resisting water erosion via self made testing apparatus anti erosion test results indicated conditions compared bases without interlayer atop erosion rate min testing bases geotextile emulsified asphalt slurry seal interlayers atop decreased respectively interlayer effects damping vibration resisting water erosion pavement base
continual advances information communication technologies ict revolutionizing virtual education bringing new tools market provide virtual solutions range problems nevertheless nonvirtual experimentation using computer aided control system design tools still fundamental future engineers paper describes control course laboratory element designed teach electronic control engineering students use networked control system steer drive electric car prototype multidisciplinary nature laboratory allows students take advantage previous academic training model plant open loop test contrast simulated behavior experimental results obtained prototype goal work students across multiple engineering disciplines able integrate knowledge acquired throughout degree studies evaluation students grades perception course conducted confirmed educational benefits approach
cloud based platforms possess security vulnerabilities additional security challenges container systems stem sharing host among independent containers malicious application break root container daemon could gain root access host kernel thereby compromising entire system could create denial service attack user applications rejecting service applications paper propose quantum network security framework cloud devise means quantum particles denoted entangled bell pairs routed network nodes enables teleportation quantum information source destination root privileges required application secure quantum channel works use policy key data easily copied regenerated spoofed without detection network framework multiple pre staged channels devised illustrate policy network routing entangle particles formulated multi tenant teleportation network capable disseminating key data servers hosting docker container applications framework achieve provably high levels security capable integration cloud data center securing applications using docker containers also describe quantum network layer protocols cloud container security leverage unique properties quantum entanglement resolve security concerns layer would control access application container daemon thereby facilitating restricted communication proper authentication
background perfectionism strongly associated obsessive compulsive disorder ocd cognitive behavioural therapy perfectionism cbt found result reductions range symptoms individuals anxiety disorders depression eating disorders aim pilot test efficacy group cbt perfectionism participants ocd elevated perfectionism method participants randomized receive immediate week group cbt week waitlist followed cbt results reliable reductions large effect size indicated cbt associated improvements perfectionism ocd severity post test however changes clinically significant drop high resulting small final sample conclusions cbt may effective reducing perfectionism disorder specific ocd symptoms however high drop rate lack clinically significant findings suggest research needs conducted determine efficacy cbt perfectionism ocd
introduction organ dysfunction failure major health issues affecting millions patients many desperate organ transplantation tissue regeneration aims providing alternative solutions innovative application cell biology materials engineering clinical practice biomaterials play critical role tissue engineering interface cell biology surgical procedures injectable stem cell carriers represent promising platform harvest therapeutic effects cells simplify surgical process areas covered review focused injectable cell carriers expected improve therapeutic outcomes also facilitate easy surgical process cell carriers include situ gelling hydrogel injectable supramolecular hydrogels microcarriers expert opinion current design hydrogels microcarriers achieve biocompatibility biodegradability provide desirable features enhance biological response overall systematic understanding stem cell behaviors synthetic microenvironment well advancement materials sciences needed design injectable biomaterials provide critical guidance full course tissue regeneration
present jump practical system capturing high resolution omnidirectional stereo ods video suitable wide scale consumption currently available virtual reality headsets system consists video camera built using shelf components fully automatic stitching pipeline capable capturing video content ods format discovered analyzed distortions inherent ods used display well introduced capture method show small enough make approach suitable capturing wide variety scenes stitching algorithm produces robust results reducing problem one pairwise image interpolation followed compositing introduce novel optical flow compositing methods designed specifically task algorithm temporally coherent efficient currently running scale distributed computing platform capable processing hours footage day
background psychological distress caregivers children autism spectrum disorder asd shown vary according characteristics care recipient especially behaviour problems trait emotional intelligence tei linked subjective reports distress familial caregivers also shown predict behaviour problems care recipient study believe first examine whether tei might moderate effect child behaviour problems cbp caregivers psychological functioning method sample parents children clinically verified asd asked complete online survey assessing tei cbp perceived stress scores pss spss process macro model bootstrapping used determine whether cbp though interaction tei might predict caregivers pss results data yielded direct relationship cbp tei caregivers pss however interaction effect observed data reflect fact caregivers children behaviour problems greater risk psychological distress caregivers lower tei relationship cbp pss however differentially affected caregivers tei conclusions findings implicate lower tei greater cbp risk factors psychological maladjustment caregivers children asd might inform design delivery tailored stress management interventions elsevier ltd rights reserved
thrombopoietin posited exist cloned ensuing two decades learned great deal physiology pathology primary regulator thrombopoiesis paper review role hormone receptor product mpl proto oncogene health disease including many unexpected effects normal neoplastic hematopoiesis amongst unexpected properties non redundant effect hematopoietic stem cells critical role three acquired chronic myeloproliferative neoplasms well gain function loss function mutations congenital acquired states thrombocytopenia thrombocythemia
dte energy electric company began pilot project use power quality monitors locate faults numerous trunk lines tie lines systems fault measurements captured meters downloaded automatically integrated relational database processed reactance calculations reactance calculations combined detailed subtransmission circuit models geographic information system data build estimated fault location tables web based map displays systems integrated company intranet used real time numerous groups within dte energy including system supervisors field operations system planning algorithm used waveform processing distinguish single phase faults multi phase faults subcycle faults feeder energizing magnetizing inrush system integrates measurements power quality monitors circuit breaker operations stored scada historian paper present overview parameters practices finding faults place every day detroit edison
ultrasonography useful tool evaluation sinovial vascularization proliferation rheumatoid arthritis accordingly resistive index spectral doppler provides quantitative analysis vascular inflammation utility evaluation activity established objective determine association parameters synovitis clinical disease activity established patients positive power doppler included prospective cross sectional study disease activity disability evaluated using disease activity score joints das health assessment questionnaire haq respectively gray scale synovitis analyses performed one two examiners wrists second third metacarpophalangeal proximal interphalangeal joints joint joint scores mean calculated weighted kappa values employed assess interobserver reability correlations tested using spearman coefficient ninety five patients median duration disease years mean das included values real time synovitis significant correlations joint joint das joint counts haq tests patients remission mean similar high disease activity versus respectively addition score seem improve performance patients established
uptake radiopharmaceutical fdg visualized pet imaging reflect abnormal myocardial inflammation utilized conjunction imaging modalities echocardiography pet fdg imaging help distinguish active cardiac sarcoidosis etiologies nonischemic cardiomyopathy present case year old man nonischemic cardiomyopathy ventricular tachycardia underwent echocardiogram suggestive cardiac chagas disease subsequent fdg pet demonstrated abnormal hypermetabolism diagnosis confirmed positive serologic examination results
background social anxiety disorder sad comorbid avoidant personality disorder apd high prevalence associated serious psychosocial problems high societal costs patients suffer sad apd dutch multidisciplinary guidelines personality disorders advise offering prolonged cognitive behavioral therapy cbt recently increasing evidence effectiveness schema therapy personality disorders borderline personality disorder cluster personality disorders since addresses underlying personality characteristics maladaptive coping strategies developed childhood treatment might particularly effective patients sad comorbid apd knowledge studies comparing cbt particular group patients superiority trial aims comparing effectiveness treatments additional goal predictors underlying mechanisms change explored methods design design study multicentre two group randomized controlled trial rct treatment effect group cognitive behavioral therapy gcbt compared group schema therapy gst semi open group format total patients aged years old enrolled patients receive sessions gcbt gst period approximately months primary outcome measures liebowitz social anxiety scale self report lsas social anxiety disorder newly developed avoidant personality disorder severity index avpdsi avoidant personality disorder secondary outcome measures mini section sad scid section apd schema mode inventory smi inventory depressive symptomatology self report ids world health organization quality life bref whoqol bref difficulties emotion regulation scale ders rosenberg self esteem scale rses acceptance action questionnaire aaq data collected start halfway end treatment followed measurements months post treatment discussion trial increase knowledge effectiveness applicability treatment modalities patients suffering diagnoses
objectives low serum bdnf levels found depressed patients study systematically investigated whether individual symptoms symptom profiles within depressed population contribute low bdnf levels found depressed subjects methods patients past month diagnosis major depressive disorder netherlands study depression anxiety nesda included composite international diagnostic interview cidi inventory depressive symptoms ids items tested individually separate multiple regression analyses serum bdnf level dependent cidi ids item independent variable subsequently compared bdnf levels patients seasonal affective disorder based seasonal pattern assessment questionnaire melancholic depression atypical depression moderate depression based latent class analysis analyses adjusted confounders results one item significantly associated serum bdnf levels namely cidi item loss interest beta counterintuitively presence symptom associated higher bdnf levels items comparison different types depression reveal significant differences conclusions decreased serum bdnf levels depression attributed specific symptom symptom cluster
paper propose workflow detect track mitotic cells time lapse microscopy image sequences order avoid requirement cell lines expressing fluorescent markers associated phototoxicity phase contrast microscopy often preferred fluorescence microscopy live cell imaging however common specific image characteristics complicate image processing impede use standard methods nevertheless automated analysis desirable due manual analysis subjective biased extremely time consuming large data sets present following workflow based mathematical imaging methods first step mitosis detection performed means circular hough transform obtained circular contour subsequently serves initialisation tracking algorithm based variational methods sub divided two parts order determine beginning whole mitosis cycle backwards tracking procedure performed cell tracked forwards time end mitosis result average mitosis duration ratios different cell fates cell death division division two daughter cells measured statistics cell morphologies obtained tools featured userfriendly matlab graphical user interface mitosisanalyser authors published elsevier inc
paper three dimensional drug model constructed investigate impact media coverage spread control drug addiction dynamical behavior model studied using basic reproduction number drug free equilibrium globally asymptotically stable results demonstrate media effect human population change stabilities equilibria affect number drug addicts sensitivity analyses performed seek effective control measures drug treatment numerical simulations given support theoretical results elsevier rights reserved
study examined role children trust beliefs trustworthiness development prosocial behavior using data four waves longitudinal study large ethnically diverse sample children switzerland mean age years time prosocial behavior directed towards peers measured assessment points teacher reports children trust beliefs trustworthiness peers assessed calculated social relations analysis first assessment point using children reports extent classmates kept promises addition teacher reports children trustworthiness assessed four assessment points latent growth curve modeling yielded decrease prosocial behavior time peer teacher reported trustworthiness predicted higher initial levels prosocial behavior peer reported trustworthiness predicted less steep decreases prosocial behavior time autoregressive cross lagged analysis also revealed bidirectional longitudinal associations teacher reported trustworthiness prosocial behavior discuss implications findings research role trust development children prosocial behavior
study presents conceptual understanding mentorship experienced participants mentorship program university students autism spectrum disorder interviewed participants autism mentorship initiative simon fraser university grounded theory approach used systematically organize data interviews documents reveal themes salient mentees students autism mentors neurotypical students following five main themes identified interrelated core theme mentee centered approach natural progression relationship supportive mentor meeting process identifying implementing goals learning together depth analysis mentorship process described
parkinson disease enhanced beta rhythm closely associated akinesia bradykinesia rigidity increase beta oscillations within basal ganglia nuclei proliferate throughout cortico basal ganglia loop uniform fashion rather subdivided two distinct frequency bands lower beta upper beta computational model excitatory inhibitory neural network focuses population properties proposed explore mechanism underlying pathological beta oscillations simulation results show several findings upper beta frequency originates high frequency cortical beta emergence exaggerated lower beta frequency depends greatly enhanced excitation reciprocal network consisting globus pallidus externus gpe subthalamic nucleus stn also transition mechanism upper lower beta oscillatory activities explore impact self inhibition within gpe relationship upper beta lower beta oscillations shown increased self inhibition within gpe contributes increased upper beta oscillations driven cortical rhythm decrease self inhibition within gpe facilitates enhancement lower beta oscillations induced increased excitability work provides analysis understanding mechanism underlying pathological synchronization neurological diseases elsevier ltd rights reserved
purpose little known regarding therapeutic role exercise risk high fat diet hfd alzheimer disease like cognitive deficits study aimed investigate therapeutic effect treadmill running hfd induced progression neuropathology cognitive impairments tripletransgenic xtg mice methods xtg mice assigned chow diet control hfd hfd combined exercise hfd group mice hfd fed fat diet hfd mice additionally subjected treadmill running results compared control mice hfd mice impaired brain insulin signaling exacerbated neuropathology defects synaptic stability plasticity apoptotic neuronal cell death conjunction exacerbated cognitive deficits affected brain regions significantly alleviated hfd mice conclusion current findings suggest treadmill running protects like disease progression cognitive deficits caused hfd xtg mice
objective hippocampal sclerosis aging aging common cause dementia older adults tested variability cerebrospinal fluid csf proteins associated previously identified aging risk single nucleotide polymorphisms snps methods alzheimer disease neuroimaging initiative cohort adni data combining multiplexed proteomics csf genotype data used assess association csf analytes risk snps four genes snps grn tmemb abcc kcnmb controls non aging snps apoe mapt also analyzed total tau csf analytes results grn risk snp status correlated variation csf proteins risk allele associated increased levels axl receptor tyrosine kinase axl tnf related apoptosis inducing ligand receptor trail vascular cell adhesion molecule vcam clusterin clu bonferroni correction trail correlation significant meta analysis additional dataset snp status associated increased csf tau protein marker neurodegeneration data remarkable since grn snp found risk factor multiple types dementia related brain pathologies elsevier inc rights reserved
previous studies indicated parenting styles important influencing factors development children well known mass migration cities china affect family relations however studies focused relationship parenting styles adolescents mental health migrant families thus study aimed investigate parenting styles could affect adolescent social anxiety migrant families total number adolescents migrant families four non government funded junior middle schools guangdong province formed research sample parenting styles measured using short form egna minnen betraffande uppfostran social anxiety evaluated using social anxiety subscale self consciousness scale results showed emotional warmth overprotection rejection significantly often perceived mothers fathers significant group differences high social anxiety group low social anxiety group found father rearing styles mother rearing styles furthermore migrant families paternal emotional warmth could decrease adolescents social anxiety whereas maternal overprotection could increase
sls selective laser sintering sls technology directly manufacturing complex structure however due limitation manufacturing engineering factor surface quality dimension accuracy green part still outstanding problem experimental methods adopted study effect part orientation machining accuracy part orientation significantly affects outline part due stair stepping phenomenon affects surface quality dimension accuracy experimental samples different part orientations including degree fabricated results indicated stair stepping phenomenon significantly affected part orientation part orientation degree dimension accuracy best part orientation mean stair stepping phenomenon smallest part structure complicated important structure dimension chosen orientation degree
work devoted investigate process electrochemical deposition antimony antimony oxychloride solution presence tartaric acid aqueous media kinetics mechanism electrodeposition process electrode surface studied proposed aid cyclic linear sweep voltammetric chronoamperometric characterization methods found process affected presence tartaric acid factors electro reduction process results also show temperature potential sweep rate concentration antimony great influence achievement electrodeposition process important parameters calculated activation energy electrochemical reaction diffusion coefficient number saturated nucleation sites electrodeposited film examined using xray diffraction scanning electron microscopy energy dispersive spectroscopy elsevier rights reserved
first semester university critical students learning process along university degrees important students get necessary habits achieve needed skills society demands one time graduate additionally known good relation success students study habits unfortunately often study habits developed entering university enough consolidated handle first year university good suitable way detection difficulties associated inappropriate study habits already detected first semester university important point improvement study habits early stage learning process contribute positively good academic progression students aim get information student profile study habits present communication results pools carried beginning end semester focused attention fundamental chemistry course mandatory first semester course belonging chemical materials engineering degrees university barcelona study analysed data correspond students enrolled course academic year information related student profile obtained basis parameters motivation preference given chemical materials engineering degrees selection process priority given university studies among activities compatibility external jobs among others concerning study habits parameters considered analysed level difficulty course compared previous chemistry courses participation classroom discussions dedication university studies distribution study time along semester among others data correlated grades obtained students university access test final exam
caring positive social act result negative attitudes towards cared towards others wider social group based intergroup contact theory tested whether care workers cws positive negative contact old age care home residents chrs predicts prejudiced attitudes towards group whether generalises older people fifty six cws surveyed positive negative contact chrs blatant subtle attitudes humanness attributions towards chrs older adults tested indirect paths contact chrs attitudes towards older adults via attitudes towards chrs results showed neither positive negative contact generalised blatant ageism however effect negative positive contact denial humanness chrs generalised subtle ageism towards older adults evidence practical implications management cws work experiences theoretical implications suggesting negative contact subgroup generalises attribution humanness superordinate groups difficult identify challenge subtle prejudices dehumanisation may especially important reduce negative contact authors journal community applied social psychology published john wiley sons ltd
objective help clarify effect gender bidirectional relationship alcohol use strenuous physical activity college students participants five hundred twenty four female college students recruited august followed april april respectively methods participants reported alcohol use strenuous physical activity occasions baseline follow spaced approximately years apart results females alcohol use quantity baseline associated increased strenuous physical activity year follow ups alcohol use frequency baseline associated decreased strenuous physical activity year follow males alcohol use frequency baseline predicted decreased strenuous physical activity year follow conclusions gender differences may explained eating disorders perspective women use physical activity compensatory strategy combat potential weight gain calories consumed alcohol use
preliminary evidence immune system cytokines may impact adhd children nevertheless studies exploring possible role pro inflammatory cytokines adults adhd lacking study aimed assess differences serum tnf alpha patients controls possible relationship resting cortisol adults adhd dsm inattentive combined age ranging years healthy controls included major psychiatric disorders organic comorbidities excluded serum samples tnf alpha salivary samples assess cortisol awakening response collected day analysis variance applied study differences tnf alpha groups pearson correlations used study associations tnf alpha car significant differences serum tnf alpha levels patients controls combined inattentive patients negative associations tnf alpha cortisol awakening response found inattentive subtype whereas association seen combined subtype negative correlation cortisol also present control group peripheral pro inflammatory markers tnf alpha appear primarily involved adhd adults although role inflammatory markers ruled differences regarding association tnf alpha morning cortisol response suggest possible underlying neurobiological differences inattentive combined patients merit studies elsevier ltd rights reserved
paper examines university student perceptions gender differences regards visual tactile interaction involved corporal expression activities study based content analysis work experience diaries students years university zaragoza spain data processed using nvivo software results showed activities require higher level emotional involvement engender higher perception gender differences women perceived expressive men iii visual preference opposite sex men fearful touching women results lead conclusion didactic intervention involves tactile visual interaction sequenced tasks lesser greater emotional commitment incorporate actions instructions facilitate rupture gender attributions impede expression
super tall buildings temperature one significant factors affect structural response however studies conducted temperature effects super tall buildings due large size complicated configuration long term structural health monitoring shm system consisting sensors types implemented canton tower tube tube super tall structure real time monitoring construction service stages one part sophisticated shm system temperature sensors deployed cross sections inner outer tubes respectively real time temperature measurement point could collected system still difficult obtain temperature distribution whole tower limited measurement points paper model typical section inner tube one column outer tube constructed investigate temperature distribution heat transfer analysis verify effectiveness model simulated results compared field monitoring data simulated results show good agreement measurements temperature distribution obtained integrating simulated measured results served input model canton tower calculate temperature induced deformation force
objective aim study investigate effects global postural education gpr treatment spinal disorders performing systematic review meta analysis design medline scopus pedro databases searched without language publication date restrictions data pain function used evaluate effectiveness gpr randomized controlled trials controlled clinical trials analyzing effectiveness gpr spinal disorders selected standardized mean difference smd corresponding confidence interval calculated meta analysis performed using comprehensive meta analysis software results seven randomized controlled trials controlled clinical trials included meta analysis results showed medium improvement pain smd function smd gpr treatment positive effect greater patients ankylosing spondylitis followed low back pain neck pain significant intermediate follow immediately treatment conclusions meta analysis provides reliable evidence gpr may effective method treating spinal disorders decreasing pain improving function
background epigenetic mechanisms provide interface environmental factors genome known play role complex diseases obesity mechanisms including dna methylation influence regulation development differentiation establishment cellular identity employ two approaches identify differential methylation two white adipose tissue depots obese individuals gastric bypass significant weight loss analyse genome wide dna methylation data using traditional paired tests identify significantly differentially methylated loci bonferroni adjusted observed changes dna methylation subcutaneous adipose omentum changes clinical trait particular cpg sites within pitx fasting glucose four cpg sites within isl hdl single cpg site atpc gave strong tissue separation validation independent subcutaneous omental adipose samples conclusions first study report genome wide dna methylome comparison subcutaneous abdominal omental adipose weight loss combinatorial approach utilised powerful tool identification methylation loci strongly differentiate tissues study provides solid basis future research focused development adipose tissue potential dysfunction obesity well role dna methylation plays processes
levonorgestrel lng dedicated emergency contraception product available counter china although lng considered effects developing fetus contraceptive fails pregnancy occurs studies specifically examining issue purpose study compare physical mental development children born lng failure cohort children born mothers history exposure lng teratogenic substances group children exposed lng mothers conception cycle study group matched group children without exposure lng control group physical mental development children evaluated compared period four congenital malformations study group three control group respectively follow period statistically significant differences two groups respect children weight height head circumference intelligence scores values parameters groups similar national standards summary lng effect physical growth mental development occurrence birth defects children born pregnancies failed
electric propulsion emerged one efficient propulsion arrangements several vessel types last decades even though examples found history end century century modern use electric propulsion started along development semiconductor switching devices used high power drives drives later drives development opened full rpm control propellers thrusters thereby enabling simplification mechanical structure however main reason using electric propulsion commercial ship applications potential fuel savings compared equivalent mechanical alternatives except icebreakers performance electric powered propeller superior combustion engine powered propeller fuel saving potential lies within fact applicable vessels highly varying operation profile seldom run full power favors power plant principle electric power produced time optimum running prime movers diesel engines turning units depending power demand propulsion vessel loads icebreakers among first vessels take advantage technology later followed cruise vessel offshore drilling vessels operating dynamic positioning converter technology rapidly developing soon drives replaced drives period electric propulsion emerged basic standard large cruise liners operated drilling vessels also found way segments shuttle tankers ferries special vessels time podded propulsion introduced electric motor mounted directly propeller shaft submerged degrees steerable pod adding better efficiency improved maneuvering reduced installation space cost benefits electric propulsion future trends focusing optimization efficiency allowing multiple energy sources independent operation individual power producers energy storage various applications power back peak shaving emission free operation short voyages
growth large scale data management capabilities successful care patients congenital heart defects coincidentally paralleled last three decades participation multicenter congenital heart disease databases registries fundamental component cardiac care manuscript attempts first time consolidate one location relevant databases worldwide including target populations specialties web sites participation information since least cardiac surgeons cardiologists began leveraging burgeoning technology create multi institutional data collections addressing variety specialties within field pediatric heart diseases particularly well suited methodology individual care location access relatively limited number diagnoses procedures given calendar year combining multiple institutions data therefore allows far accurate contemporaneous assessment treatment modalities adverse outcomes additionally data used develop outcome benchmarks individual institutions measure progress field whole focus quality improvement efforts directed fashion increasing utilization combining clinical research efforts within existing data structures efforts ongoing support better collaboration integration across data sets improve efficiency utility data collection infrastructure information collected enhance return investment participating institutions
objective questionnaires often used assess results nasal septoplasty response rates vary widely possible bias caused non responders evaluated determine validity questionnaire results methods post operative questionnaires employing visual analogue scales nasal obstruction mailed patients non responders per cent contacted telephone per cent contactable responded orally questionnaire results non responders younger different responders regard gender smoking habits allergies post operative visual analogue scale obstruction scores slightly statistically higher non responders however non responders pre operative scores lower obstruction scores improved less responders main reason responding forgetfulness would preferred electronic version questionnaire conclusion although post operative obstruction scores differ groups nasal obstruction scores improved among responders non responders thus low response rates may cause bias
part incentives government set ambitious environmental targets relating energy consumption including reduction carbon emissions use various technologies help meet targets well providing secure energy source future research took case study investigated reduction measures suited reduce energy consumption paper presents review current state art domestic technology available particular solar energy heat pumps phase changing materials pcms micro combined heat power micro chp systems aiming identifying research development opportunities energy saving fields furthermore financial well environmental aspects assessed two key considerations typical household typical house design including floor plan created use computer aided design cad software house design gives payback period years best years worst
aims aim investigate autonomic nervous system imbalance hypertrophic cardiomyopathy hcm combining echocardiographic morphological functional parameters analysis autonomic responses orthostatic stress methods min tilting test transthoracic echocardiogram focused ventricular septal systolic wave diastolic function isovolumic relaxation time performed low frequency high frequency ratio variation variation beat beat intervals response passive orthostatism used measures sympathetic reflex activation delta delta drr respectively brain natriuretic peptide measured results total hcm patients categorized two groups group sympathetic response less group parasympathetic response patients group higher new york heart association class frequent history atrial fibrillation versus syncope versus increased septal isovolumic relaxation time versus categorization made according lowest quartile drr drr least group sympathetic response drr less group parasympathetic response group patients older advanced new york heart association class higher history atrial fibrillation conclusions autonomic response passive orthostatism hcm appears correlated specific functional features hypertrophic heart altered neural afferent traffic localized area segmental hypertrophy resulted autonomic changes blunted sympathetic response inappropriate vagal activation especially patients history atrial fibrillation syncope
system measuring dielectric properties cereal grains mhz coaxial sample holder presented signal flow graph model used determine permittivity several polar alcohols full two port parameter measurements lowest frequencies mhz phase measurements less accurate lumped parameter model used predict dielectric loss factor values system calibrated measurements air decanol verified measurements octanol hexanol pentanol standard error polar alcohols used verification dielectric constant dielectric loss factor although measurements taken static samples sample holder designed accommodate flowing grain
concept green building integrates variety strategies design construction operation building projects use green building materials represents one crucial strategy design construction building recycling green building materials refer building materials reproduced materials namely reclaim waste discarded materials produce building materials taiwan gypsum boards widely used building industry facing materials walls ceilings due good mechanical thermal properties well fire endurance goal study develop new recycling green building material could reuse daily waste materials color changeable give inspiration improve characters green building materials study six waste materials daily lives mixed allochroic powder gypsum powder create thermochromic face bricks experiment modules groups mixed allochroic powders different specifications findings showed group significant rgb variation terms value group variations six materials wood chips newspaper concrete fallen leaves iron powder silt conclusion allochroic faced bricks applied interior exterior walls different types buildings future thus buildings different colors different temperatures times cater changeful effects future architectural appearances regarding landscape building interior designers construct artistic creations shell collages elsevier ltd rights reserved
design pole inner rotor permanent magnet synchronous machine buried shaped ndfeb magnets power contin short term overload maximum speed described use medium sized hybrid electric car double drive range extender based specifications vehicle two stage transmission two identical electrical machines one synchronous machines designed electromagnetically mechanically thermally high power weight ratio via intensified liquid jacket cooling led construction prototype machine thoroughly tested test results load load conditions discussed effectiveness chosen cooling system verified temperature measurements tests show prototype machine certain reserve final machine design done cheaper compact
article analyzes problem complicity wrongdoing case healthcare practitioners particular roman catholic ones refuse perform abortions nonetheless required facilitate abortions informing patients option referring willing colleague although solution widely supported literature also widely represented much legislation argument fails safeguard well patients protect moral integrity healthcare practitioners finally article proposes new solution problem based desirable ratio conscientious objectors non conscientious objectors hospital given geographic area
introduction pregnancy anxiety important psychosocial risk factor may strongly associated adverse birth outcomes measures stress better understanding upstream predictors causes pregnancy anxiety could help identify high risk women adverse maternal infant outcomes objective present study measure associations five past pregnancy outcomes live preterm birth ptb live term birth miscarriage weeks stillbirth weeks elective abortion pregnancy anxiety three trimesters subsequent pregnancy methods analyses conducted using data cohort study canadian birth cohort data maternal demographic characteristics pregnancy history known previous pregnancy collected via interviewer administered questionnaires study entry pregnancy anxiety index study pregnancy measured prospectively self administered questionnaire following three prenatal study visits results participants study least one previous pregnancy linear regression analyses adjustment confounding variables prior live term birth associated lower pregnancy anxiety three trimesters whereas prior miscarriage significantly associated higher pregnancy anxiety first trimester prior stillbirth associated greater pregnancy anxiety third trimester prior elective abortion significantly associated higher pregnancy anxiety scores first second trimesters association similar magnitude observed third trimester discussion findings suggest outcomes previous pregnancies incorporated along demographic psychosocial characteristics conceptual models framing pregnancy anxiety
data hiding wide field helpful secure network communications common many data hiding researchers consider improving increasing many aspects capacity stego file quality robustness paper use audio file cover propose reversible steganographic method modifying sample values using modulus function order make reminder particular value secret bit needed embedded addition use location map locates modified sample values reversible data hiding needs exactly recover secret message original audio file stego file experimental results show method measured correlation algorithm able retrieve exactly secret message audio file moreover made significant improvement terms following capacity since sample value carrying secret bit quality measured peak signal noise ratio psnr signal noise ratio snr pearson correlation coefficient pcc similarity index modulation sim proven quality stego audio relatively high
physical physiological changes elderly people make difficult perform control basic house works people lose progressively autonomy independence moreover probability total partial abandonment increasingly high limiting adequate monitoring person health could prevent many problems typical aging generating alerts appropriate actions order mitigate problems work solution based ambience intelligence proposed idea provide assistance elderly people everyday actions system includes automation home processes use information gathered daily activities person order operate multi agent system central intelligent component utilizes registered information make decisions oriented wellbeing person based analysis behavior patterns
objectives temporomandibular disorders may associated dental facial malformations aim study record prevalence tmds patients scheduled orthognathic surgery reporting development tmds symptoms entire period treatment demonstrating benefits team effort population materials methods assessment temporomandibular status performed using rdc tmd criteria prior orthodontic therapy months surgery post therapeutic cycle months postoperatively total participants included study patients underwent surgical treatment bilateral sagittal split osteotomy condylar position devices fort bilateral sagittal split osteotomy condylar position devices results evaluated paired sample test segmentation analysis results forty seven patients affected tmds patients experienced tmj pain muscular pain suffered headaches disc dislocation reduction affected disc dislocation without reduction thirty five patients occlusal signs parafunctions reported tinnitus dizziness tmj pain changed muscular pain changed headaches improved disc dislocation segmentation analysis highlighted improvement therapy patients considered recovered improved none considered stable whereas patients demonstrated worsening presented disc dislocation surgery patients considered completely recovered improved conclusions data indicates beyond doubt functional status pain levels related tmds significantly improved multi disciplinary approach concluded surgeon intervention need modified presence presurgical tmds
study consists validation scale analysis violent behavior adolescents cross sectional observational study total adolescent students public private schools city recife pernambuco state participated study responding questionnaire semantic content validation performed followed dimensionality reliability discriminant trust convergent analysis extraction method principal component analysis varimax rotation kaiser normalization analysis resulted scale assessment aggressive behavior teenagers items seven factors selected cronbach total alpha discriminant analysis revealed groups items distinguish subjects high low level violent behavior groups items revealed positive correlation among items reliability instrument confirmed retest scale revealed evidence validity tool assessing violent behavior among adolescents
alternative fuel become significant important role play spark ignition compression ignition engines need trim dependency gasoline fuel economic aspects emerged reason prime importance various investigations carried primarily focused using alternative fuel see diminishing effect fuel consumption aim review study analyze range opportunities future prospects introducing blend gasoline ethanol gasoline alcohol derivative subsequent alternative fuel varying percentage ratios existing engines diagnosing various aspects air fuel ratio operating cylinder pressure ignition timing compression ratio related performance parameters
background parenting style may important determinant individual future weight status however reviews evaluate relationship parenting style weight related outcomes focused prospective studies methods systematically searched pubmed embase psychinfo studies published evaluated prospective relationship parenting style experienced childhood subsequent weight outcomes results identified prospective cohort studies among eight studies categorized parenting style distinct groups authoritative authoritarian permissive neglectful five provided evidence authoritative parenting associated lower body mass index gains among six highest quality studies four suggested protective role authoritative parenting style adverse weight related outcomes however one study controlled comprehensive set confounders small number studies conducted within certain age groups precluded ability ascertain critical periods parenting style strongly related child weight conclusions present literature supports idea authoritative parenting may protective later overweight obesity although findings mixed prospective cohort studies longer durations sophisticated methods examine age varying relationships control comprehensive set confounders needed
conducted interpretive phenomenological investigation order understand within cambodian sociocultural context lived experiences women infected hiv husbands navigated tasks discovering disclosing dealing diagnosis using open ended interview protocol interpretive phenomenological approach data analysed women aged years self identified hiv transmission coming spouses using qualitative inductive analysis able identify three main themes finding oneself hiv positive encountering hiv accepting unwelcomed guest going public dealing fear discrimination participants consistently delayed testing hiv receiving hiv positive diagnosis deal painful emotions discrimination within social network complexity gender roles sociocultural status women acted behavioural determinants responses hiv transmission spouses
interconnections national power systems developed parallel networks country originally interconnections used get outside help case failure could affect security country national electricity supply electrical power networks small oscillations appear time time oscillations concern quantities determining equilibrium point system following system stability system behaviors influenced improve system behaviors dynamic stability necessary minimize transient states objective study first check static stability high voltage power small perturbations electrical network context present study based modal analysis linearized system results analysis allow obtain optimal placement power regulators pss injected input voltage regulator avr based matrix participation calculation parameters performed regulators method residues paper study structured around one main objective real interconnection tunisia libya stable efficient solider operation
humans use multiple senses navigate social world sense smell arguably underestimated one intriguing aspect sense smell social communicative function research shown human odors convey information range states emotions sickness traits individuality gender yet underlies communicability states traits via smell fill explanatory gap framework highlights dynamic flexible aspects human olfactory communication particular explain chemical profiles associative learning systematic occurrence chemical profiles state trait related information top contextual influences could interact shape human odor perception model helps integrate past research human olfactory communication also opens new avenues future research fascinating yet date poorly understood field
people unconsciously unintentionally make inferences others personality traits based behaviours study classic memory phenomenon proactive interference first time used detect spontaneous trait inferences occur lists behaviour descriptions implying trait remembered switching new trait produce release proactive interference rpi results two experiments supported predictions rpi effects consistent interactive activation competition model person perception mcneill burton exp psychol predicts categorical organization social behaviours based personality traits advantages model discussed
objective study investigate whether clinical laboratory data birmingham vasculitis activity score bvas five factor scores ffs diagnosis could predict relapse patients polyarteritis nodosa pan follow duration months reviewed medical charts patients pan obtained clinical laboratory data diagnosis compared two groups based relapse optimal cut values bvas ffs diagnosis predict relapse extrapolated mean age patients men years mean follow duration months nine patients experience relapse remission patients relapse showed higher frequency weight loss ocular symptoms less frequency diastolic hypertension multivariate logistic regression analysis weight loss independent predictor relapse cox hazard model analysis statistical significance disappeared mean initial bvas ffs patients relapse group higher patients relapse group patients initial bvas ffs exhibited significantly higher risk relapse respectively however initial bvas remained significant kaplan meier survival analysis conclusion bvas diagnosis independent predictor relapse pan
study objective describe clinical characteristics patients referred domestic minor sex trafficking dmst improve identification intervention design retrospective cohort study setting lawrence aubin child protection center hasbro children hospital patients evaluated child abuse pediatricians outpatient emergency department inpatient settings participants total patients younger age years referred evaluation dmst involvement august march interventions main outcome measures collected demographic social environmental medical psychiatric variables medical records patients referred evaluation self disclosed reported evidence histories place high risk dmst involvement results children frequent contact medical providers seen year referral dmst childhood maltreatment family dysfunction identified sexual abuse parental substance abuse patients children medical problems sexually transmitted infection psychiatric needs acute suicidality least previous psychiatric admission substance use although runaway lived group home placement currently lived home presented parent guardian relative conclusion children referred dmst present frequently physicians complex medical psychiatric needs medical providers increased awareness health issue would inform victim identification intervention
integrated engineering subject many specialists concerned problem integrated engineering depends way cad capp stages solved also way information transfer phases ensured present paper focused phase process planning presents innovative original capp system system strongly related product design cad concept constructive technological entity applied facilitates capp stage present paper presents system structure working
objective identify characteristics retinal vessels associated recurrent cerebral infarction establish predictive model recurrent cerebral infarction study methods patients cerebral infarction included study including patients new onset cerebral infarction patients recurrent cerebral infarction retinal vessel characteristics patients analyzed reported automated retinal image analysis system retinal clinical characteristics compared recurrent new onset subjects multivariate logistic regression used identify risk factors associated recurrent ischemic stroke within year initial stroke onset results every unit increase vessel caliber measures central retinal artery vein equivalent found give coronary heart diseases additional times confidence interval risk stroke recurrent whereas every increased unit arterial venous angles would associated times increase risk among atrial fibrillation subjects measures bifurcation coefficient arterioles showed opposite effects interacted different clinical factors negative integrations found venous asymmetry index various factors atrial fibrillation odds ratio confidence interval coronary heart diseases odds ratio confidence interval bifurcation coefficient arterioles odds ratio confidence interval indicating decreased recurrent risk among subjects venous asymmetry level increases conclusions retinal vessel characteristics interacted well traditional clinical risk factors affecting risk stroke recurrence national stroke association published elsevier inc rights reserved
novice programmers misconception programming early stages learning programming flowchart based programming environment fpe developed research aim introducing early stages learning programming clarify matters attempt made introduce basic programming algorithms prior surface structure using automatic text flowchart conversion approach order improve students problem solving skills thus system allows students focus less language syntax solution designing form flowchart development main objective study support problem solving ability designing activities exactly fpe employs text flowchart conversion visualization based approach provide students final flowchart subsequent stages programming discussed paper proposed system evaluated using first year undergraduate students taking first introductory courses programming called programming university malaya gave positive feedback awarding finding automatic text flowchart conversion approach applied fpe successfully motivated almost participants problem solving activities consequently results suggest development text flowchart conversion approach form multi agent system mas future order make early stages learning programming encouraging students
although early sexual initiation linked negative outcomes unknown whether effects causal study use propensity score methods estimate causal effect early sexual initiation young adult sexual risk behaviors health outcomes using data national longitudinal study adolescent adult health found early sexual initiation predicted two partners males females sexually transmitted infection past year females predict depressive symptoms past week either gender results underscore importance continued programmatic efforts delay age sexual initiation particularly females
background research conducted investigate effects nursing supportive program anxiety stress levels family members patients admitted intensivee care unit icu cardiac surgery methods research quasi experimental study control group intervention group comprised family members post cardiac surgery patients admitted icu studied intervention group received nursing supportive program initially hours patients entered icu day thereafter days control group received routine information demographic variables adjusted depression anxiety stress scales dass used assess anxiety stress levels family members patients results demographic variables dass scores statistically significant differences stress levels groups intervention however intervention mean score stress level intervention group dropped significantly comparison control group anxiety levels groups reduced intervention however although statistically significant difference observed groups hours icu admission icu day significant difference icu day conclusions light findings present study nursing supportive program aimed providing information emotional mental support reassurances family members post cardiac surgery patients hospitalized icu able decrease stress levels extent anxiety levels
objective explore validity assessment tool development emotional inferencing stories test eist measure designed assess ability people traumatic brain injury tbi make inferences emotional state others solely contextual cues methods procedures study stories presented healthy young adults data two versions eist eist eist created study version administered group participants moderate severe tbi eist group participants eist group participants participants also completed facial affect recognition danva test participants facial affect recognition impairment returned weeks later administered tests main outcomes participants tbi scored significantly lower healthy group mean eist eist eist scores eist group significantly lower eist group danva scores significantly correlated eist scores eist eist test test reliability scores eist adequate conclusions versions eist found sensitive deficits emotional inferencing development eist may provide clinicians valuable information intervention planning
study examined whether sleep disturbance predicted moderated responses psychotherapy participants participated step national multisite study examined effectiveness different treatment combinations bipolar disorder participants received either brief psychosocial intervention called collaborative care intensive psychotherapy study based pharmacotherapy participants defined current past week short sleepers hours night according reported average nightly sleep duration week randomization sleep disturbances predict likelihood recovery time recovery depressive episode difference recovery rates versus normal sleepers medium effect sizes observed differences short long sleepers study sleep play major role predicting moderating response psychotherapy bipolar disorder
power system minimizing power loss transmission lines minimizing voltage deviation load buses controlling reactive power referred optimal reactive power dispatch orpd paper presents improved evolutionary algorithm based oppositional krill herd algorithm okha obtaining optimal steady state performance power systems article also proposes effect upfc location steady state analysis demonstrate capabilities upfc controlling active reactive power flow within electrical network verify effectiveness kha okha two different single objective functions minimization real power losses improvement voltage profile multi objective function simultaneously minimizes transmission loss voltage deviation studied standard ieee bus bus test systems results reported study results show proposed kha okha approaches feasible efficient elsevier ltd rights reserved
introduction fatigue acknowledged safety risk diverse operational settings result growing interest developing implementing activities improve alertness performance safety real world operations fatigue factor methods comprehensive alertness management program amp included education alertness strategies scheduling healthy sleep implemented commercial airline operational evaluation conducted flight crewmembers first flying standard schedule without amp components standard condition compared full amp implementation included flying innovative schedule incorporated physiological sleep alertness principles intervention condition evaluation included objective measures sleep quantity actigraphy psychomotor vigilance task pvt performance subjective reports daily activities sleep results results showed educational improved pre education test scores average correct post education average alertness strategies showed minimal changes though daily diary allow refined evaluation duration frequency timing use intervention condition associated significantly sleep min trip period compared standard schedule performance metrics showed significantly better performance intervention condition trip schedule compared standard condition discussion first ever evaluation comprehensive amp showed significantly improved knowledge support use alertness strategies increased sleep performance actual operations robust consistent findings support use amp approach effectively manage fatigue operational settings
objectives use intrauterine devices iuds women low despite suitability women reproductive age variety clinical contexts study examined obstetrician gynecologists practices opinions use iuds adolescents nulliparous women patient groups well emergency contraception design survey questionnaire sent computer generated sample fellows reflective american college obstetricians gynecologists college membership results exclusions returned surveys response rate eligible questionnaires analyzed almost obstetrician gynecologists reported providing iuds considered nulliparous women considered adolescents appropriate candidates even among obstetrician gynecologists recalled reading college publication iuds considered nulliparous women adolescents appropriate candidates respectively respondents recommended copper iud emergency contraception agreed copper iud could used emergency contraception total respondents agreed inserted immediately abortion miscarriage fewer agreed rid inserted immediately postpartum provide services respectively staying informed practice recommendations long acting reversible contraception associated broader provision iuds conclusions although obstetrician gynecologists offer iuds many exclude appropriate candidates iud use emergency contraception long term use despite evidence based recommendations implications study shows obstetrician gynecologists still offer iuds appropriate candidates nulliparous women adolescents rarely provide copper iud emergency contraception elsevier inc rights reserved
root zone water balance model used simulate soil moisture storage maize zea mays rice oryza sativa fields rainfed uplands eastern india simulation study revealed short duration days rice fields uplands remained ponding condition period days entire growing season based ponding depth requirement rice fields excess ponding found seven days days ponding contrast maize field similar length growing season days topographic condition could produce harvestable runoff days furthermore rice crop remain moisture stress eight days mid season stage whereas maize found without stress entire growing season sowing winter crops soil moisture seeding zone determined depleted germination soil moisture years years simulation rice maize fields respectively implies second crop following withdrawal monsoon possible without pre sowing irrigation three five years rainfed uplands thus complete substitution rice maize uplands would create better scope rainwater harvesting alternatively partial replacement rice could viable option meeting rice demand people harvesting adequate rainwater supplemental irrigation crops rainy winter seasons iagre published elsevier ltd rights reserved
nowadays serious security problems imperfection implementations network protocols imperfection bring lot vulnerabilities could allow malicious user attack systems remotely using network protocols internet developers value software security phases involving review code risk analysis testing penetration fuzzing case fuzz testing main aim find vulnerabilities software application sending inputs expected target monitor situation target many applications internet things iot http wikipedia org wiki internet things http wikipedia org wiki internet things targettype environments working file transfer protocol ftp based applications study present fuzzing framework applied test network protocol implementations extendable man middle smart mostly deterministic tool like autofuzz gorbunov rosenbloom autofuzz automated network protocol fuzzing framework department mathematical computation sciences university toronto mississauga canada ability learn given protocol implementation building finite state automaton records communication traces client server additionally tool ability learn syntax individual messages lower level using techniques bioinformatics beddoe network protocol analysis using bioinformatics algorithms http www tphi net awalters pdf last framework fuzz given server protocol specification changing communication traces server client applied multiple implementations ftp server result finding new known vulnerabilities
product related service key element service oriented manufacturing system paper presents methods capture standardization knowledge european integrated project manufacturing service engineering msee goal initiate development standards domain manufacturing engineering services purpose project internal survey performed identify areas potential standardization lead future standards survey coordinated follow within project subsequent external promotion foreseen early involvement standardisation process explored since normal standardisation process usually starts completion development project due lack funding supported developers
using portable field device fourier transform infrared spectroscopy ftir partial least squares regression plsr method developed rapid min prediction major minor fatty acid concentrations marine oil omega dietary supplements calibration models developed gravimetrically prepared samples models tested using independent validation set dietary supplements fas analyzed included eicosapentaenoic acid epa docosahexaenoic acid dha sums saturated branched chain monounsaturated fas trans polyunsaturated spectral ranges provided reliable predictions components neat oil products standard error prediction residual predictive deviation simple nondestructive quantitative method rapid screening tool time cost saving alternative gas chromatography verifying label declarations quality control
filtering control mathematical engineering areas common use model based approach splits problem two steps model identification model based design despite success model based approach shortcoming design objective taken account identification step model optimized intended use technical note proposes approach data driven filtering control combines identification model based design one joint problem signal interest modeled missing part trajectory data generating system subsequently missing data estimation problem reformulated mosaic hankel structured matrix low rank approximation completion problem local optimization method based variable projections principle used numerical solution missing data estimation approach solution method proposed illustrated filtering smoothing examples
aim current study evaluate role gamma amino butyric acid gaba insulin disturbance hyperglycemia associated brain oxidative damage streptozotocin treated rats streptozotocin stz administered male albino rats single intraperitoneal dose body weight gaba body weight day administered daily via gavages weeks stz treated rats male albino rats sprague dawley weeks old body weight divided groups rats treated parallel control group received distilled water gaba group received gaba stz group stz treated rats received distilled water stz gaba group stz treated rats received gaba rats sacrificed fasting period next last dose gaba results obtained showed stz treatment produced hyperglycemia insulin deficiency similar type diabetes changes associated oxidative damage brain tissue notified significant decreases superoxide dismutase catalase activities parallel significant increases malondialdehyde advanced oxidation protein products levels histopathology reports also revealed stz treatment produced degeneration pancreatic cells administration gaba stz treated rats preserved pancreatic tissue improved insulin secretion improved glucose level minimized oxidative stress brain tissues could concluded gaba might protect brain oxidative stress preserve pancreas tissues adjusting glucose insulin levels diabetic rats might decrease risk neurodegenerative disease diabetes
aim aim present study compare positive negative urgency well sleep quality among patients borderline personality disorder bpd antisocial personality disorder aspd sample method causal comparative study sample included patients diagnosed aspd patients diagnosed bpd well healthy controls subjects selected based availability instruments used lynam impulse control scale pittsburgh sleep quality index results results show mean negative urgency significantly higher bpd patients aspd patients whereas mean positive urgency significantly higher aspd patients bpd patients dimensions sleep quality bpd aspd patients significantly higher healthy controls discussion significant difference exists among bpd aspd patients healthy controls positive negative urgency sleep quality conclusion found bpd aspd patients manifest reckless behaviours due negative urgency experiencing negative emotional situations due positive urgency experiencing positive emotional situations patient groups show lower sleep quality diagnostic therapeutic implications
purpose paper analyze dynamic characteristics proposed digital peak current mode converter waveforms output voltage reactor current derived small signal analysis compared simulation results assuming actual large amplitude operation confirmed tendency transient response indicated based analysis results experimental result proposed method shows validity proposed method gradual response obtained improvement stability converter consequently proposed method solution implementing peak current mode control digital
kidneys play critical role homeostasis body fluid tonicity effective circulating volume renal homeostatic mechanisms frequently challenged acutely ill people fluid depletion causing hypovolemia may result renal hypo perfusion left untreated may lead acute kidney failure populations notably older people neonates less tolerant extremes fluid loading deprivation similar established chronic kidney disease risk kidney injury fluid depletion increased medications including diuretics nonsteroidal antiinflammatory drugs renin angiotensin system blockers consistent evidence indicating lower average fluid intake cause chronic kidney disease accelerate progression established kidney disease increasing consumption sugar containing beverages however major concern kidney health precursor obesity diabetes evidence high dietary protein intake cause chronic kidney disease accelerate progression established kidney disease idiosyncratic adverse renal responses described creatine supplements clinical conditions high fluid intake considered include recurrent kidney stones urinary tract infections possibly polycystic kidney disease
although alzheimer disease criteria promote use biomarkers maturity clinical routine still needs assessed light oncology framework conducted literature review measures used assess delayed recall impairment due medial temporal lobe dysfunction free cued word list recall tests ample evidence available phases rationale use discriminative ability early detection ability many tests routine use evidence phase performance real world phase quantify impact costs yet come administration procedures standardized cutoff scores well validated large alzheimer disease mild cognitive impaired series aspects different task formats however hamper comparability results among different populations reproducibility laboratories definite guideline use thus proposed moment accordingly maturity markers yet sufficient requires future investigation promote proper use memory measures clinical settings elsevier inc rights reserved
glycosylation many proteins revealed closely related food allergies screening structural analysis related glycoproteins glycoallergens essential studies field herein describe detailed glycoform analysis glycoprotein fractions soybean protein isolate spi separated sodium dodecyl sulfate polyacrylamide gel electrophoresis sds page disclose structural features glycan moieties soybean glycoproteins spi fractionated sds page generated protein bands recovered subjected gel glycan release labeling using one pot method newly developed group followed detailed analysis electrospray ionization mass spectrometry esi online hydrophilic interaction liquid chromatography coupled electrospray ionization tandem mass spectrometry hilic esi result found seven bands mainly containing oligomannose type glycans two mainly contain core alpha facosylated glycans six glycans study first report discovers core alpha fucosylated glycans bands discloses bands glycoproteins glycoforms therefore expand knowledge soybean protein glycosylation provide significant structural reference research soybean allergens
study investigated response inhibition individuals psychopathic traits examined cortical source localization nogo stimuli nogo task employing standardized low resolution electromagnetic tomography sloreta using eeg fifteen psychopathic trait subjects control subjects performed nogo task statistical analysis elicited nogo stimuli indicated psychopathic trait group showed significantly reduced nogo amplitudes control group frontocental area wisconsin card sorting test psychopathic trait group showed significantly higher perseverative responses control group compared control group cortical sources reduction elicited nogo psychopathic trait group found left superior frontal gyrus bilateral anterior cingulate right precentral gyrus right inferior parietal lobule results suggest individuals psychopathic traits difficulties inhibiting response reduced frontal function elsevier rights reserved
last years research activities regarding software environmental impacts could find way field green thus researchers became aware fact software one drivers energy consumption ict however awareness aspects could much higher especially non scientific area one side software developers aware green strategies software engineering side using products need responded effects using ict products onto environment one idea transfer environmental effects software social issue create eco label software products next defining criteria label could laid methods evaluate software products seems helpful identify aspects influencing acceptance certification green software products context acceptance means taking eco label account searching new software hence following paper aims identifying aspects applying technology acceptance model tam specific case labelling green software products present first version acceptance model label green software products still work progress needs evaluated next step generally aim create tool used develop eco label software products strongly accepted
joint industry academia projects regional industry influenced creation florida first coast manufacturing innovation partnership development collaboration primary goals project centered innovations technology transfer training regional workforce relevance industry sustainability technology transfer creation high technology jobs providing experiential education manufacturing systems automation design undergraduate engineering curriculum engineering students better prepared upon entering workforce initial projects leading development manufacturing innovation partnerships outlined followed description structure expand scope experiential project centered engineering education design manufacturing systems engineering
numerous studies shown exposure media violence increases aggression though mechanisms effect remained elusive one theory posits repeated exposure media violence desensitizes viewers real world violence increasing aggression blunting aversive reactions violence removing normal inhibitions aggression theoretically violence desensitization reflected amplitude component event related brain potential erp associated activation aversive motivational system current study violent images elicited reduced amplitudes among violent compared nonviolent video game players additionally reduced brain response predicted increased aggressive behavior later task moreover effects held controlling individual differences trait aggressiveness data first link media violence exposure aggressive behavior brain processes hypothetically associated desensitization elsevier inc rights reserved
article presents cognitive agent based software tool teaching software change control decisions tool simulates cognitive processes software professionals involved software change decision allows students assess reasoning comparison agent one experimental results proved proposed tool well accepted students wiley periodicals inc
background brain thrombin activity increased following acute ischemic stroke may play pathogenic role protease activated receptor par order better assess factors obtained novel detailed temporal spatial profile thrombin activity mouse model permanent middle cerebral artery occlusion pmcao methods thrombin activity measured fluorescence spectroscopy coronal slices taken ipsilateral contralateral hemispheres following pmcao mice respectively spatial distribution determined punch samples taken ischemic core penumbra confirmed using enzyme histochemistry technique levels par determined using western blot results two hours following pmcao thrombin activity stroke core already significantly higher contralateral area thrombin activity continued rise linearly expand ischemic hemisphere beyond ischemic core reaching deleterious levels mean sem basal ganglia ischemic cortex respectively peak elevation thrombin activity ischemic core confirmed fluorescence histochemistry good correlation infarcts areas par levels ischemic core decreased stroke progressed thrombin activity increased conclusion conclusion time space related increase brain thrombin activity acute ischemic stroke closely related progression brain damage results may useful development therapeutic strategies ischemic stroke involve thrombin par pathway order prevent secondary thrombin related brain damage
objective methotrexate mtx effective used treat chronic inflammatory diseases also induces apoptosis nasal polyps nps increasing evidence suggests fas fas ligand fasl interactions activate multiple pathways involved regulation immune inflammatory cell functions aim present study identify pathways activated fas signaling nps treated mtx methods nasal polyps tissues cultured using air liquid interface organ culture method cultures maintained absence presence mtx hours authors used reverse transcription polymerase chain reaction method western blotting identify pathways activated fas nps treated mtx results fas mrna expression ratio unchanged upon mtx treatment fasl mrna expression ratio significantly higher mtx treated nontreated polyps addition expression levels fas fasl proteins significantly higher polyps treated mtx compared nontreated polyps conclusions methotrexate induces apoptosis nps via fas pathway future studies explore topical use mtx control methotrexate may useful alternative steroid sparing agent treatment nps
demand side response dsr recognised potential bring economic benefits various electricity sector actors energy retailers transmission system operators tsos distribution network operators dnos however dsr provided large industrial commercial consumers little research directed quantification value small commercial residential end users could accrue providing dsr services particular suitable models studies needed quantify potential business cases dsr small commercial residential end users models studies consider technical physical characteristics power system demand resources together economic conditions power market addition majority research focuses provision energy arbitrage ancillary services little attention dsr services network capacity support accordingly paper presents comprehensive techno economic methodologies quantification three capacity based business cases dsr small commercial residential end users case study results applied context indicate appropriate regulatory framework put place services capacity support dnos tsos result potentially attractive business cases dsr small end users minimum impact comfort level elsevier ltd rights reserved
prospective study examined injury incidence injury type causative factors effect playing status injuries occurring among soccer players invitational tournament injury incidence player hours mild contusions sprains strains predominating player player contact player ground contact accounted injuries females higher incidence injuries results support studies show soccer relatively safe sporting activity youth implications continued safety may include adjustments playing conditions females proper preparation playing surfaces education coaches safe coaching practices consistent refereeing
microscale mechanical networks prevalent lab ona chip systems rapidly expanding biological chemical physical research systems nano liter volumes fluids manipulated precise control flow individual segments within complex network often desirable one paradigm control suggests adjusting hydraulic resistance segment relying fact like electrical circuits fluid flow depended upon relation potential drop pressure difference resistance transmitting conductor current solutions control hydraulic resistance rely intricate fabrication processes often characterized high biased error generally produce limited range resistance computer aided design six bit digitally controlled adjustable hydraulic resistor features five linear ranges resistance small footprint presented design rapidly embedded within microfluidic network real time control fluid flow
perinatal trends presented article based recent topics conferences journals media well input perinatal nurses trends patient care influenced evidence known decades new research emerging innovative concepts healthcare patient family preferences media trends discussed article rethinking due date birth outside hospital setting obstetric hospitalists birth attendants nitrous oxide pain childbirth hydrotherapy waterbirth hospital setting delayed cord clamping disrupters optimal infant microbiome skin skin care cesarean surgery breast sleeping breast feeding dyad addition authors developed implications perinatal nurses related trend goal stimulate reflection evidence supports support current practice stimulate future research discussing current trends may influence care perinatal nurses provide birthing year
objectives age related changes expression hormonal receptors well examined fallopian tube herein report effect menopause hormone receptors ampullae fts afts comparison cortical inclusion cysts cics ovary methods total afts fimbriae fts obtained premenopausal postmenopausal women postmenopausal cics immunohistochemically studied expression estrogen receptor alpha alpha progesterone receptor pra apoptotic cells identified using tunel assay results postmenopausal afts showed significantly lower labeling index apoptosis pra premenopausal afts significant correlation immunohistochemical markers found premenopausal afts pra positively correlated inversely postmenopausal afts expression immunohistochemical markers closely correlated ampullae fimbriae signature detected five postmenopausal afts mean age years detected cics immunohistochemical profile low expression apoptosis pra high expression expression pra cics significantly higher afts conclusion expression pra significantly lower postmenopausal afts premenopausal afts whereas expression pra well preserved postmenopausal cics
parental mentalizing parent ability envision child smental states desires thoughts wishes argued underlie parent ability respond sensitively child emotional needs thereby promote advantageous cognitive socio emotional development mentalizing typically operationalized terms parents talk infants work extends research mentalizing operationalizing parental mentalizing exclusively terms nonverbal bodily based interactive behavior namely parental embodied mentalizing pem purpose current researchwas twofold establish reliability validity pem coding system evaluate whether measurement predicts infant child cognitive socio emotional functioning assessing mother infant dyads months using coding pem proved reliable valid including predicting child attachment security months language abilities academic skills behavior problems social competence months many cases even taking consideration traditional measures parenting namely maternal sensitivity conceptual empirical clinical implications discussed
cell cll lymphoma protein bcl multi functional factor wnt signaling induced carcinogenesis well promoting tumor progression metastasis chemo resistance colorectal cancer crc however mechanisms increased bcl expression crc well understood report hypoxia hallmark solid tumors induced bcl mrna expression human crc cells analysis bcl promoter revealed two functional hypoxia responsive elements hre hre specifically bound transactivated hypoxia inducible factors hif alpha hif alpha consistently ectopic expression hif alpha hif alpha transcriptionally induced bcl expression levels cells knockdown endogenous hif alpha hif alpha sirna largely abolished induction hif hypoxia furthermore strong association hif alpha expression bcl expression human crc specimens summary results study demonstrated hypoxia induced bcl expression human crc cells mainly hif alpha could important underlying mechanism increased bcl expression crc
optimization defined operation finding best solution problem operation performed changing initial parameters using existing data various optimization algorithms solve kinds problems however expected optimization algorithms offer proper effective solution optimization problems therefore necessary select proper algorithm using similar benchmark functions problem determine best parameter values selected algorithm study test tool run devices using windows android ios operating systems developed eight different optimization algorithms genetic artificial immune differential evolution particle swarm optimization simulated annealing tabu search artificial bee colony ant colony optimization algorithms six hump camel back rastrigin shubert schwefel drop wave preferred benchmark functions special user defined special functions also permitted developed test tool tested optimization algorithms different platforms spite small differences running times results show tool easily used windows android ios devices wiley periodicals inc
malignant melanoma one dangerous skin cancer originating melanocytes thus early proper melanoma diagnosis influences significantly therapy efficiency melanoma recognition still difficult generally relies subjective assessments particular lack quantitative methods used melanoma diagnosis monitoring tumour progression one method atomic force microscopy afm working force spectroscopy mode combined quartz crystal microbalance qcm applied quantify molecular interactions study compared recognition mannose type glycans melanocytes hema melanoma cells originating radial growth phase lung metastasis glycosylation level surfaces probed using lectin concanavalin con canavalia ensiformis interactions con surface glycans quantified afm qcm techniques revealed presence various glycan structural groups cell dependent manner con mannose glucose type glycans present cell surface rather short less ramified cells con binds long branched mannose glucose types oligosaccharides elsevier rights reserved
contracts feel misunderstood especially higher order soul software engineers appreciate contracts tools articulating interface components functional programmers desperately search types meaning completely forgetting pragmatics gem presents novel analysis contract systems applied higher order kind analysis reveals large clearly unappreciated software engineering potential three sample applications illustrate kind exploration may lead
big temperature rising principle problem constrains application permanent magnet synchronous motors high power density electric aircrafts electric aircrafts paper proposed novel conception hybrid temperature control method using phase change material permanent magnet synchronous motors design models hybrid cooling casing cylinder shape developed prototype case optimized paraffin phase change material built set experimental equipment constructed verify thermal managing performance hybrid cooling method impacts different heat loads various working duty cycles cooling effectiveness casing analyzed experimentally parametrically results indicate hybrid temperature control method performs well extending duration work time decreasing temperature rising motor design models developed paper could suitable designing parallel systems elsevier inc rights reserved
purpose previous studies primarily assumed dysfunctional effects cultural distance joint ventures paper elucidates positive organizational scholarship perspective perceived cultural distance advance firms new product development within non equity alliances purpose paper explain perceived cultural distance stimulates task discourse supports alliance partners employees recognizing applying culture related differences complementary problem solving potentials due lower integration level non equity alliances compared joint ventures paper assumes positive effects outweigh negative effects cultural distance design methodology approach study applies structural equation modeling test hypothesized effects sample international alliances manufacturing industry findings analysis mainly supports hypothesized model unravels positive effects emerge perceived cultural distance practical implications findings provide managerial implications alliance managers note cultural distance positive negative effects thus barrier per alliances firms benefit cultural distance able leverage culture specific complementarities task discourse among partners alliances originality value manuscript uses unique data set international alliances global manufacturing industry manuscript published elsewhere
acquired brain injury abi becoming epidemic problem society especially among older adults known silent epidemic people abi demand solutions research offer relearning process recover physical skills also cognitive abilities context inherent characteristics ambient intelligence ami transparency intelligence turned one best approaches square impairment abi cause ami proposes development context aware systems integrate different devices recognize context act accordingly systems react promptly needs people abi carry rehabilitation process moreover explbitation multi agent architecture emerges natural solution develop ami systems since agents reactive proactive exhibit intelligent autonomous behavior therefore paper multi agent architecture mas healthcare aml systems presented contributes treat people abi using specific devices control patient movements physiological responses variation heart rate rehabilitation process way natural relationship ami mas exploited finally system used design execute therapies people abi presented
hill classical cipher generally believed resistant ciphertext attack paper using divide conquer technique first shown hill key matrix broken computational complexity english language much less publicly known attack brute force complexity using chinese remainder theorem shown computational complexity proposed attack reduced using information theoretic approach shown minimum ciphertext length required successful attack increases factor respectively two attacks comparison brute force attack serious attack hill since invention elsevier rights reserved
background biomembrane force probe approachable experimental technique commonly used single molecule force spectroscopy experiments biological interfaces technique operates range forces experiments typically repeated many times conditions often optimal captured video unstable lose focus makes efficient analysis challenging box non proprietary solutions freely available results dedicated tool developed integrate simplify image processing analysis videomicroscopy recordings bfp experiments novel processing feature allowing tracking pipette incorporated address limitation preceding methods emphasis placed versatility comprehensible user interface implemented graphical form conclusions integrated analytical tool implemented provide faster simpler convenient way process analyse bfp experiments
batch processes great importance process industry however control algorithm design difficult constraints stability recursive feasibility along directions time batch guaranteed simultaneously paper stable model predictive control strategy zero terminal state constraints proposed stability recursive feasibility along two directions guaranteed proved simulation results given show effectiveness algorithm ifac international federation automatic control hosting elsevier ltd rights reserved
study introduces concept chronic repeated cumulative mediated exposure political violence investigates effects aggressive behavior post traumatic stress pts symptoms young viewers embracing risk matrix approach effects studied alongside childhood risk factors influence maladjustment longitudinal study conducted sample youth experience israeli palestinian conflict firsthand hypothesized higher levels chronic mediated exposure longitudinally related higher levels pts symptoms aggression peers independently exposure violence contexts case aggressive behavior structural equation analysis sem analyses suggest likely causal effects directions bigger effect probably exposure violence stimulating aggression aggression stimulating exposure violence longitudinal effects aggression pts symptoms especially strong among youth demonstrated initially higher levels type maladjustment results support conceptualization relation media violence behaviors reciprocally determined downward spirals highlight contribution risk matrix approach analysis childhood maladjustment
background quantified impact lifestyle dietary modifications chronic kidney disease ckd estimating population attributable fractions pafs study design observational cohort study setting participants middle aged adults type diabetes without severe albuminuria ongoing telmisartan alone combination ramipril global endpoint trial ontarget factors modifiable lifestyle dietary risk factors physical activity size social network alcohol intake tobacco use diet intake various food items outcomes primary outcome ckd ascertained moderate severe albuminuria annual decline estimated glomerular filtration rate egfr years competing risk death considered paf defined proportional reduction ckd mortality within years would occur exposure risk factor changed optimal level results baseline median urinary albumin creatinine ratio egfr iqr mmol iqr min respectively years participants developed albuminuria annualegfrdecline died physically active every day pafs ckd death among food items increasing vegetable intake would largest impact population health considering diet weight physical activity tobacco use size social network exposure less optimum levels gives pafs ckd death million middle aged americans diabetes improving lifestyle behaviors optimal range could reduce incidence progression ckd years number deaths within years limitations ascertainment changes kidney measures precisely match definitions incidence progression ckd conclusions healthy lifestyle diet associated less ckd mortality may substantial impact population kidney health kidney dis authors published elsevier inc behalf national kidney foundation inc open access article license
ambient intelligent systems home building automation systems hbas becoming evermore accepted capable actuating automatically behalf users fulfil requests enable activities however multiple users interact systems requirements activities often interfere resulting conflicting actuations hbas ought automatically detect resolve yet despite recent advances hbas ambient intelligent solution reported adequately grounded knowledge analysis contributions article twofold first reviews relevant literature ambient intelligence conflict detection conflict resolution knowledge representation hbas second proposes validates ontological framework conflict detection resolution backed knowledge based analysis effectively proposed solution performs automatic environment actuations maximizing users comfort energy efficiency elsevier ltd rights reserved
sporadic familiar forms non histaminergic angioedema normal inhibitor encompass group disorders possibly caused bradikinin aimed study subgroups hereditary angioedema fxii mutation fxii hae unknown genetic defect hae idiopathic non histaminergic acquired angioedema inh aae screened locus cohort delineated clinical laboratory genetic features four families carried thrlys mutation gene haplotyping confirmed hypothesis common founder six families affected hae patients sporadic inh aae levels significantly lower fxii hae inh aae fxii hae group none attacks exclusively high estrogenic states acute attacks treated icatibant prophylaxis tranexamic acid reduced attack frequency patients study provides new data diagnosis clinical features treatment non histaminergic angioedema underlying role screening mutations elsevier inc rights reserved
paper present framework managing qualitative spatiotemporal patterns framework designed large scale monitoring systems systems generate huge amount real time data various formats end users interested finding significant data configurations based expertise attempt leverage large amounts data generated acquisition systems several software tools proposed help users achieve goals however available solutions mostly based relational databases use sql queries support functionalities systems allow real time detection situations interest also called patterns domain due weak expressiveness sql queries present novel approach based complex event processing real time detection situations interest based events states spatial objects leverage rich semantics qualitative pattern representation model present complete solution qualitatively represent patterns detect instances event cloud thanks approach user able react detected patterns instead trying identify mine patterns databases proposed current approaches
purpose icatibant bradykinin receptor antagonist approved treat acute hereditary angioedema attacks adults date thorough investigation clinical pharmacokinetic parameters icatibant primary metabolites reported present results two phase clinical studies icatibant healthy human volunteers methods single multiple dose plasma pharmacokinetics icatibant characterized healthy volunteers icatibant concentration time profiles parameters derived single dose three doses given hour intervals results maximal plasma concentrations doses achieved hour postdose total plasma icatibant exposure doses respectively elimination half life values hours respectively conclusions single subcutaneous administration icatibant exhibited dose proportional appreciable accumulation upon repeated doses administered hour intervals
harnessing nonlinear optical effects photonic chip scale proven useful number key applications optical communications microwave photonics also benefit adoption technology creating new concept nonlinear integrated microwave photonics discuss potential chip nonlinear processing towards creation robust multifunctional microwave photonic mwp processors also highlight key recent results field including frequency agile mwp filters ultrawideband signal generators
ultrasound technology hormone assays provided better understanding folliculogenesis ovulation south american camelids last two decades females exhibit waves ovarian follicular growth induced ovulators therefore exhibit oestrous cycles manner spontaneously ovulating species sheep cattle much variation inter wave interval among camelid species alpaca llama days vicuna days within species within individual animals range phase follicular growth wide ovulation occurs mating luteolysis occurs approximately days later conception fails occur elsevier rights reserved
normalization tumor microenvironment selectively targeting components tumor extracellular matrix recently proposed potential decompress tumor blood vessels increase vessel perfusion thus improve drug delivery efficacy cancer therapy therefore need identify safe well tolerated pharmaceutical agents able remodel microenvironment solid tumors enhance chemotherapy study repurposed pirfenidone clinically approved anti fibrotic drug treatment idiopathic pulmonary fibrosis investigate possible role tumor microenvironment normalization using two orthotopic mammary tumor models demonstrate pirfenidone reduces collagen hyaluronan levels result significantly increases blood vessel functionality perfusion improves antitumor efficacy doxorubicin reduction extracellular matrix components mediated via tgf beta signaling pathway inhibition due downregulation tgf beta cola cola expression levels findings provide evidence repurposing pirfenidone could used promising strategy enhance drug delivery solid tumors normalizing tumor microenvironment
active matrix organic light emitting diode amoled display driver enabling real time thin film transistor tft nonuniformity compensation presented hybrid driving method satisfy fast driving speed high tft current accuracy high aperture ratio proposed hybrid column driver drives mobile uhd amoled panel one horizontal time scan frequency simultaneously senses tft current back end tft variation compensation due external compensation simple pixel circuit employed pixel accurate current sensing high panel noise immunity guaranteed proposed current sensing circuit reusing hybrid column driver circuitries driver embodies bit current mode adc measure oled transfer characteristic oled luminance degradation compensation measurement results show hybrid driving method reduces maximum current error two emulated tfts threshold voltage difference gray level error gray level bit gray scales gray level circuit reused current mode adc achieves lsb dnl lsb inl
introduction mucinous cystic neoplasm mcn solid pseudopapillary neoplasm spn pancreas uncommon hormone related pancreatic tumors hrpts clear predominance young women trial aims investigate possible association hrpts development males phenotypic sex hormone alterations methods performed retrospective analysis database february february risk factors sexual dysfunction considered exclusion criteria investigated secondary sexual characteristics development sex hormone level overall sexual dysfunction degree according international index erectile function questionnaire iief results initially identified patients mcn spn follow patients lost resulted dead excluded according exclusion criteria finally enrolled patients mcn spn puberty occurred within physiological age patients whereas delayed cases three patients revealed mild moderate sexual dysfunction along low testosterone level two cases one patient presented hormonal alteration normal iief score discussion study first literature similar aim hormonal sexual dysfunction present patients affected hrpt rarity lesions makes trials needed reliable conclusions surgical associates ltd published elsevier ltd rights reserved
background numerous studies demonstrate even use statins many patients unable meet ldl goals study examined modifications statin ezetimibe therapy among patients hyperlipidemia prior history cardiovascular events commercially insured population methods adults age years initiating statins ezetimibe january december identified healthcore integrated research database index date initiation date statins ezetimibe patients medical claims related myocardial infarction unstable angina ischemic stroke transient ischemic attack coronary artery bypass graft percutaneous coronary intervention within months prior index date treatment modifications statins ezetimibe initiated index date index therapy included permanent discontinuation lipid lowering therapy llt rechallenge switching subtraction augmentation dose changes results among patients around initiated statin monotherapy followed statin ezetimibe combination years years ten percent less initiated high intensity statins common treatment modifications rechallenging index therapy years years switching years years permanent discontinuation llt years years patients groups underwent dose escalation conclusions real world evidence indicates high risk patients initiate therapy high intensity statins patients underwent rechallenge switching despite high cvd risk profile approximately patients permanently discontinued llt key limitations pharmacy claims provide information whether patients pharmacy fill actually took medication prescribed unknown whether rechallenge simple delay filling prescription actual rechallenge index therapy reasons treatment discontinuations modifications unavailable claims data
influenza virus infection causes acute highly contagious respiratory illness triggers cell death infected cells airway epithelial destruction rip key regulator cell death responses growing number viral microbial agents study aimed investigate role rip inflammation influenza virus infection rip knock rip mice littermate wild type mice infected intranasally influenza virus fujian determine contribution rip inflammatory response influenza virus infection found rip mice infected virus showed higher survival less weight loss compared wild type littermate mice addition rip mice fewer regions edema infiltration inflammatory cells alvelolar collapses secretions beta rantes mip balf significantly decreased days compared mice moreover caspase beta signaling found invovled rip associated imflammation influenza virus rip mlkl dependent necrosis conclusion results indicated rip deficiency protect mice infection influenza virus downregulating caspase beta signaling provided edivence rip invovled necroptosis independent manner
paper describes improved parallel mpi based implementation vbarms variable block variant parms preconditioner proposed solving general nonsymmetric linear systems parallel vbarms solver detect automatically exact approximate dense structures linear system exploits information achieve improved reliability increased throughput factorization novel graph compression algorithm discussed finds approximate dense blocks structures requires one simple use parameter complete study numerical parallel performance parallel vbarms presented analysis large turbulent navier stokes equations suite three dimensional test cases elsevier rights reserved
paper presents platform distributed computing developed using latest software technologies computing paradigms enable big data mining platform called clowdflows implemented cloud based web application graphical user interface supports construction execution data mining workflows including web services used workflow components web application clowdflows platform poses software requirements used modern browser including mobile devices constructed workflows declared either private public enables sharing developed solutions data results web scientific publications server side software clowdflows multiplied distributed number computing nodes developer perspective platform easy extend supports distributed development packages paper focuses big data processing batch real time processing mode big data analytics provided several algorithms including novel ensemble techniques implemented using map reduce paradigm special stream mining module continuous parallel workflow execution batch mode real time processing mode demonstrated practical use cases performance analysis shows benefit using available data learning distributed mode compared using subsets data non distributed mode ability clowdflows handle big data sets nearly perfect linear speedup demonstrated elsevier rights reserved
security implications social bots evident consideration fact data sharing propagation functionality well integrated social media sites existing social bots primarily use really simple syndication osn online social network application program interface communicate osn servers researchers profiled behaviors well proposed various mechanisms defend predict web test automation rootkit wtar prospective approach designing malicious social bots paper first present principles designing wtar based social bots second implement three wtar based bot prototypes facebook twitter weibo third validate new threat analyzing behaviors prototypes lab environment internet analyzing reports widely used antivirus software analyses show wtar based social bots following features connect osn directly therefore produce network flows log osns easily perform variety social activities iii mimic behaviors human user osn finally propose several possible mechanisms order defend wtar based social bots copyright john wiley sons ltd
pax functions nodal point neural stem cell maintenance differentiation using bioinformatics methods identified pax potential regulator beta tubulin iii tubb gene transcription results indicated pax might involved neural stem cell nsc differentiation orchestrating expression cytoskeletal proteins present study reported pax could inhibit differentiation nscs expression tubb using luciferase electrophoretic mobility shift assays demonstrated pax could bind promoter region tubb inhibit tubb transcription finally confirmed pax could bind promoter region endogenous tubb native chromatin nscs findings indicated pax pivotal factor targeting various molecules differentiation nscs vitro elsevier inc rights reserved
article studies application multiobjective evolutionary algorithms solving energy aware scheduling problem workflows distributed system composed federation datacenters nowadays energy efficiency major concern using large distributed computing systems including novel grid cloud computing facilities researchers system planners looking accurate methods used planning execution large workloads consume large amounts resources direct implications energy consumption system operational costs approach proposed article study application multiobjective evolutionary algorithms combined low level backfilling heuristics finding efficient mappings workflows resources order maximize several metrics related quality service reducing energy required computation experimental evaluation performed considering medium large workloads model realistic high performance computing applications modern distributed computing infrastructures experimental results demonstrate proposed multiobjective evolutionary approaches compute accurate schedules significantly outperforming traditional round robin load balancing schedulers set combined list scheduling heuristics accounting problem objectives previously applied problem
simulation becomes important aspect within digital factory planning virtual commissioning automated plants production industry promising method ensure quality adherence delivery dates process however building simulation models often paired high efforts stand benefits paper shows effort minimized automatic generation simulation models
present study copolymerization ethyl acrylate guar gum induced microwave irradiation presence catalytic amount initiator potassium persulfate kps maximum percentage conversion found microwave power min exposure copolymerized guar gum graft poly ethyl acrylate pea characterized using ftir spectroscopy sem analysis effect capacity pea copolymers reduce hardness water investigated leading effective removal ions solutions calculated values coefficient determination respectively showed equilibrium isotherm data followed freundlich isotherm model pseudo second order model suitable modelling kinetic data predicting adsorption capacities min min respectively synthesized pea adsorbent could therefore recommended reduction water hardness
exercise inducible laryngeal obstruction eilo recognized rare respiratory problem youth practicing sports aim study test mechanosensitivity larynx identify factors affecting group youth proven eilo laryngeal sensory testing performed adolescents young adults eilo laryngeal mucosal alterations assessed according reflux finding score rfs data concerning diseases possibly affecting upper airway findings previously performed flexible videolaryngoscopy exercise rfs score compared participants laryngeal hyposensitivity normal sensitivity participants isolated vocal folds adduction eilo attack compared demonstrated supraglottis collapse testing revealed increased threshold mechanical stimuli participants among participants hyposensitivity significantly participants dysphagia eilo attacks among participants normal laryngeal sensitivity hyposensitivity group significantly higher rfs score compared group isolated vocal folds approximation observed participants participants younger asthma frequently compared others participants eilo state symptoms related gastroesophageal reflux decreased mechanosensitivity detected majority participants suggesting laryngopharyngeal reflux important etiological factor problem breathing difficulties sport activities youth also associated disproportionate growth respiratory tract copyright wolters kluwer health inc rights reserved
paper provides selective eraser curvature extrema spline curves introduced extension standard least squares method approximating series points using spline extension consists adding constraints produce segments curve monotone increase decrease curvature primal dual interior point method used solve constrained optimization problem method requires gradients computed using spline symbolic operators therefore algorithm relies arithmetic differential properties splines variation diminishing property splines also exploited apply constraints application examples consist producing fair curves measured points airfoils data come publicly available uiuc database data contains fair amount noise airfoils especially circumstances fixed number segments monotonic variation curvature hold great promise produce curves general uncompromising oscillations elsevier ltd rights reserved
organisms including humans developed daily rhythms almost every aspect body surprising rhythms also related affect health disease present review present data demonstrate evidence significant interactions circadian rhythms affect human studies animal models research number lines evidence obtained human animal models research clearly demonstrate relationships depression circadian rhythms including daily patterns depression seasonal affective disorder connections circadian clock genes depression relationship sleep disorders depression antidepressant effect sleep deprivation antidepressant effect bright light exposure effects antidepressant drugs sleep circadian rhythms integration data suggests relationships circadian system depression well established underlying biology interactions far understood suggest important factor hindering research underlying mechanisms lack good animal models propose additional efforts area made one step direction could attempt develop models utilizing diurnal animals might better homology humans regard circadian rhythms article part special issue entitled anxiety depression elsevier ltd rights reserved
recent contributions framed linear system identification nonparametric regularized inverse problem relying type regularization accounts stability smoothness impulse response estimated approaches shown competitive classical parametric methods paper adopting maximum entropy arguments derive new penalty exploit structure hankel matrix thus controlling time complexity measured mcmillan degree stability smoothness identified models special case recover nuclear norm penalty squared block hankel matrix contrast previous literature reweighted nuclear norm penalties kernel described small number hyper parameters iteratively updated marginal likelihood maximization constraining structure kernel acts hyper regularizer helps controlling effective degrees freedom estimator optimize marginal likelihood adapt scaled gradient projection sgp algorithm proved significantly computationally cheaper first second order shelf optimization methods paper also contains extensive comparison many state art methods several monte carlo studies confirms effectiveness procedure elsevier ltd rights reserved
research interaction emotional expressions social category cues face processing focused whether specific emotions associated single category identities thus overlooking influence intersectional identities instead examined quickly people categorise intersectional targets race gender emotional expression experiment participants categorised black white faces displaying angry happy neutral expressions either race gender emotion influenced responses men versus women gender made salient task similarly emotion influenced responses black versus white targets participants categorised race experiment participants categorised faces emotion neither category salient predicted responses black women differed black men white women thus examining race gender separately insufficient understanding emotion social category cues processed
canadian digestive health foundation initiated scientific program assess incidence prevalence mortality economic impact digestive disorders across canada current article presents updated findings study concerning pancreatitis
context technical debt metaphor describes effect immature artifacts software maintenance bring short term benefit project terms increased productivity lower cost may paid interest later much research performed propose mechanisms identify debt decide appropriate moment pay important investigate current state art order provide researchers practitioners information enables research activities well technical debt management practice objective paper following goals characterize types technical debt identify indicators used find technical debt identify management strategies understand maturity level proposal identify visualization techniques proposed support technical debt identification management activities method systematic mapping study performed based set three research questions total studies dated evaluated results proposed initial taxonomy technical debt types created list indicators proposed identify technical debt identified existing management strategies analyzed current state art technical debt identifying topics new research efforts invested conclusion results mapping study help identify points still require investigation technical debt research elsevier rights reserved
auranofin used clinic treatment rheumatoid arthritis repurposing anticancer drug finished phase clinical trial developmental toxicity remains obscure study focused developmental toxicity using zebrafish embryos zebrafish embryos exposed different concentrations post fertilization hpf hpf hpf two major developmental defects caused found namely severe pericardial edema hypopigmentation embryos exposed concentrations higher biochemical detection oxidative stress enzyme combined expressions series genes related oxidative stress cardiac metal stress pigment formation subsequently tested superoxide dismutase activity decreased malondialdehyde content accumulated treatment expression oxidative stress related genes sod gpxa gst pigment related genes mitfb trp one metal stress related gene ctr decreased exposure expressions cardiac related genes amhc vmhc one metal related gene hsp found significantly upregulated exposure findings indicated potential developmental toxicity zebrafish early development copyright john wiley sons ltd
debate representation brain nature cognitive system going decades paper examines neurophysiological evidence primarily single cell recordings get better perspective issues initial review basic concepts paper reviews data single cell recordings cortical columns category selective multisensory neurons neuroscience columns neocortex cortical columns understood basic functional computational unit paper reviews fundamental discoveries columnar organization finds reveals massively parallel search mechanism columnar organization could extensive neurophysiological evidence widespread use localist representation brain paper also reviews studies category selective cells evidence category selective cells reveals localist representation also used encode complex abstract concepts highest levels processing brain third major issue nature cognitive system brain whether form purely abstract encoded single cells provide evidence single cell based purely abstract cognitive system paper reviews findings related multisensory cells appears widespread usage multisensory cells brain areas sensory processing takes place plus evidence abstract modality invariant cells higher levels cortical processing overall reveals existence purely abstract cognitive system brain paper also argues since evidence dense distributed representation since sparse representation actually used encode memories actually evidence distributed representation brain overall appears abstract level brain massively parallel distributed computing system symbolic paper also explains grounded cognition theories brain fully compatible localist representation purely abstract cognitive system
background empathy personality feature play major role predicting emotional social functioning adolescents jolliffe farrington recent research confirms existence two fundamental dimensions embedded within construct affective empathy experiencing congruent emotional response another person cognitive empathy understanding rationally emotions another person basic empathy scale jolliffe farrington date instrument reported satisfactorily measure two dimensions method used sample adolescents males females aged completed spanish adaptation bes results confirmatory factor analysis showed spanish adaptation scale factorial structure original cfi adaptation also showed satisfactory reliability cronbach alpha coefficient discriminant convergent validity regard measurements narcissism psychoticism agreeableness females found higher scores males affective cognitive empathy subscales show direct significant correlation age conclusions evidence suggested revised scale possessed good psychometric properties evaluating empathy spanish young people
aluminum absorbed digestive system water drinks food contains natural traces processed food food cooked aluminum cookware studies show people exposed high levels aluminum may develop kidney bone brain diseases aluminum foil alfesi daily used packaging food drugs stored refrigerator electric motor induces magnetic field microteslas purpose work study corrosion behavior various aluminum packaging foils effect weak magnetic field morphology corrosion kinetics mass fractions nacl solutions mean results various aluminum packaging foils show localized corrosion controlled electrochemical potentials different phases constituting aluminum foil concentration precipitates phases morphology corrosion kinetics aluminum packaging foil mass fractions nacl solutions different without application weak magnetic field electrochemical tests applied cheese packaging paper show introduction magnetic field decreases polarization resistance potential passivation value open circuit potential beginning corrosion however passivation current density increases beginning corrosion values open circuit potential without weak magnetic field thirty days corrosion
transceivers architectures integrate concept sotware radio case mobile terminal hard constraints imposed factor mobility low power complex circuits claimed telecommunication industry classical architectures sufficient challenge goal new systems thus proposed concept software defined radio sdr step roadmap toward software radio paper presents state art sdr circuits explores application analog signal processor chip
study problem designing data structure reports positions distinct iota majorities within range array without storing iota majority range iota element occurs iota times show omega inverter right perpendicular log iota inverter left perpendicular bits necessary data structure able count number distinct iota majorities range design structure using inverter right perpendicular log iota inverter left perpendicular bits returns one position iota majority iota log log iota log time ram machine word size output position iota majority occurs omicron additional time finally show remove log factor time adding omicron log log bits space structure
several reports described presence antibodies alzheimer disease associated hyperphosphorylated forms tau serum healthy individuals characterize specificities found interrogated peripheral igg memory cells asymptomatic blood donors reactivity panel phosphorylated tau peptides using single cell screening assay antibody sequences recovered cloned expressed full length iggs total somatically mutated tau binding antibodies identified corresponding unique clonal families forty one antibodies recognize epitopes proline rich terminal domains binding antibodies strictly phosphorylation dependent thirteen antibodies showed inhibitory activity lysate seeded vitro tau aggregation assay two antibodies cbtau cbtau bind proline rich terminal regions tau respectively characterized detail cbtau recognizes epitope similar murine anti phf antibody different phospho requirements cbtau cbtau detect pathological tau deposits post mortem brain tissue cbtau reveals similar ihc distribution pattern immunostaining pre tangles threads neuritic plaques cbtau shows selective detection neurofibrillary changes ihc taken together results suggest presence ongoing antigen driven immune response tau healthy individuals wide range specificities tau suggests human immune repertoire may contain antibodies serve biomarkers exploited therapy
supervised classification large training data common decision trees widely used however bottlenecks memory restrictions time complexity data complexity many supervised classifiers including classical tree directly handle big data one solution problem design highly parallelized learning algorithm motivated propose parallelized decision tree algorithm based mapreduce tree parallelized methods build tree nodes first information entropy based parallelized attribute selection method several subsets tree proposed confirm best splitting attribute cut points data splitting method parallel presented partition training data subsets last introduce tree learning algorithm grows top recursive way besides depth constructed decision tree number samples maximal class probability tree node used termination conditions avoid partitioning problem experimental studies show feasibility good performance proposed parallelized tree algorithm
measurement bone strain key factor bone biology studies understand changes structure bone mass helpful improvement treatment process patients suffered due bone diseases system design bone strain requires components include sensors amplifiers analog digital converters adc filter processing unit whenever bone loaded creates small adjustment bone mass measurement bone strain system requires accuracy minimum variation structure bone mass strain gauge sensors used sense change interconnected plates bone mass strain strain minimum value range micros desires processed get original value strain processing signal easier digital signal compared analog signal hence voltage signal sensor measuring strain transmitted transmitted signal amplified operational amplifier analog signal converted digital using comparator circuit operational amplifier comparator circuit designed using complementary metal oxide semiconductor cmos technology reduce power consumption simulated help mentor graphics system takes long time measure strain system power consumption low thus analysis strain useful treatment orthopedic diseases
paper present evaluation dbd reactor generates energy per pulse order inactivate coli atcc cfu order concentrations cloacae cdbb cfu order concentrations volume water flowing continuously particularly experimentation focused atmospheric pressure dbd reactor coupled peristaltic pump type cooling jacket containers water treatment cooling fluid systems monitor experimental conditions implementation experiments carried three different fluid flow rates time required carry cycle treatment corresponded respectively dbd application water flowed continuously recirculation mode promoting continuous oxygen injection three established fluid flow rates efficacy treatment reached inactivation coli bacteria order concentrations end first cycle treatment cfu order concentration complete inactivation coli bacteria achieved end fourth cycle treatment meanwhile cloacae bacteria showed inactivation end first cycle treatment order concentration order concentration increased efficacy process depended fluid flow rate survival end first cycle treatment nevertheless highest additional cycle required
speed control motor critical industrial systems accuracy protection essence paper presents simulations proportional integral derivative controller pid bit pic series microcontroller speed control motor presence load torque pid gains tuned linear quadratic regulator lqr technique implemented microcontroller using mplab finally simulated speed control motor proteus virtual system modeling vsm software proteus built feature add load torque motor simulation results presented three cases speed motor controlled without load torque load torque load torque three cases pid effectively controls speed motor minimum steady state error
firms today average forecasts collected multiple experts models cognitive biases strategic incentives structure machine learning algorithms forecasts often overfit sample data overconfident little known challenges associated aggregating forecasts introduce theoretical model examine combined effect overfitting overconfidence average forecast combined effect mean median probability forecasts poorly calibrated hit rates prediction intervals high low respectively consequently prescribe use trimmed average trimmed opinion pool achieve better calibration identify random forest leading machine learning algorithm pools hundreds overfit overconfident regression trees ideal environment trimming probabilities using several known data sets demonstrate trimmed ensembles significantly improve random forest predictive accuracy
headache disorders occuring symptoms human population basis successful therapy headaches definite diagnosis needs turn valid criteria graduation headaches corresponding classification international headache society ihs especially relevant questions patient history clinical examination lead diagnosis
background aimas best estimates functional gastrointestinal disorders fgids prevalence expected community studies scanty asia evaluated prevalence risk factors fgids rural indian community methodshouse house survey undertaken trained interviewers using translated validated rome iii hospital anxiety depression questionnaires resultamong subjectsyears old villages uttar pradesh participated finally analyzed subjects age years male vegetarian non vegetarian socioeconomic classes upper upper middle lower middle upper lower lower using prasad classification fgids dyspepsia irritable bowel syndrome ibs dyspepsia ibs overlap rome iii criteria subjects dyspepsia epigastric pain postprandial distress syndromes eps pds eps pds overlap ibs often diarrhea constipation predominant subtype univariate analysis chewing tobacco aerated drink tea coffee disturbed sleep vegetarianism anxiety parameters presence dyspepsia predicting occurrence ibs associated fgids multivariate analysis chewing tobacco aerated soft drink tea coffee vegetarianism anxiety parameters presence dyspepsia predicting ibs significant conclusionfunctional gastrointestinal disorders particularly dyspepsia ibs overlap common rural indian population risk factors included chewing tobacco aerated soft drink tea coffee vegetarian diet disturbed sleep anxiety dyspepsia predicting occurrence ibs
objective investigate association perception expressed emotion psychopathology school going adolescents non clinical sample methods cross sectional field study conducted kocaeli turkey comprised high school students school years data collected using information collection form strengths difficulties questionnaire shortened level expressed emotion scale spss used data analysis results subjects girls boys overall median age inter quartile range years significant positive relationships scales terms emotional problems behavioural problems attention deficit hyperactivity disorder peer relationship problems also negative significant relationship pro social behaviours expressed emotion conclusion concept perceived expressed emotion non clinical adolescents useful alarming clinicians preventing mental disorders
investigated association five factor model personality traits neuroticism extraversion openness agreeableness conscientiousness risk dementia cognitive impairment dementia cind conversion cind dementia large national cohort participants health retirement study completed personality scale cognitive status tracked years using modified telephone interview cognitive status ticsm adjusting age sex education race ethnicity lower conscientiousness agreeableness higher neuroticism independently associated increased risk dementia associations remained significant adjusting risk factors dementia including income wealth smoking physical inactivity obesity diabetes hypertension blood biomarkers associations modified age sex race ethnicity education suggesting associations personality risk dementia similar across demographic groups neuroticism conscientiousness also associated risk cind low conscientiousness predicted conversion cind dementia using brief assessments personality cognition found robust evidence personality associated risk cognitive impairment dementia large national sample elsevier ltd rights reserved
time triggered architectures form important component many distributed computing platforms safety critical real time applications avionics automotive control systems tta flexray ttcan examples time triggered architectures popular recent times architectures involve number algorithms synchronizing set distributed computing nodes meaningful exchange data among algorithms include startup algorithm whose job integrate one nodes group communicating nodes startup algorithm runs every node system powered failure occurs critical issues need considered design startup algorithms example algorithms robust reasonable assumptions failures nodes channels safety critical nature applications algorithms used demands rigorous verification algorithms numerous attempts use formal verification techniques purpose paper focuses various formal verification efforts carried ensuring correctness startup algorithms particular verification different startup algorithms used three time triggered architectures tta flexray ttcan studied compared contrasted besides presenting various verification approaches algorithms gaps possible improvements verification efforts also indicated
background current development sequencing technologies towards generating longer noisier reads evidently accurate alignment reads play important role downstream analysis similarly reducing overall cost sequencing related time consumption aligner tradeoff accuracy speed main challenge designing long read aligners results propose meta aligner aligns long long reads reference genome efficiently accurately meta aligner incorporates available short long aligners subcomponents uses statistics reference genome increase performance meta aligner estimates statistics reads reference genome automatically meta aligner implemented runs popular posix like operating systems linux conclusions meta aligner achieves high recall rates precisions especially long reads high error rates also improves performance alignment case pacbio long reads comparison traditional schemes
background role speckle tracking echocardiography assessment chronic aortic regurgitation established load dependency may encumber interpretation strain measurements chronically overloaded left ventricle aim study investigate mechanisms left ventricular contraction patterns asymptomatic patients moderate severe preserved ejection fractions methods prospective cross sectional study patients moderate severe elite endurance athletes healthy control subjects examined using three dimensional speckle tracking echocardiography global circumferential strain gcs global longitudinal strain gls end systolic circumferential wall stress essc end systolic meridional wall stress essm wall stress ratio essc essm measured results end diastolic volumes similar athletes patients significantly larger healthy control subjects values gls control subjects athletes patients respectively control subjects athletes patients whereas values gcs respectively athletes control subjects patients essc essm ratio lower patients adjusted essm gls remained impaired patients compared control subjects athletes hand gcs better patients adjusted essc conclusions compensated relatively high gcs compensates reduced gls manner consistent preserved ejection fractions observed patients
restoration channelized streams returning coarse sediment stream edges wetted channel become common practice sweden yet restoration activities always result return desired biota study evaluated restoration project vindel river northern sweden practitioners increased channel complexity previously restored stream reaches placing large boulders trees salmonid spawning gravel adjacent upland areas channels one reach restored basic methods another enhanced methods selected ten different tributaries main channel geomorphic hydraulic complexity enhanced chemical composition riparian soils communities riparian plants fish exhibit clear responses enhanced restoration measures first years compared reaches restored basic restoration methods variation collected data among streams instead types restored reaches conclude restoration disturbance immigration potential varies across landscapes biotic recovery processes boreal river systems slow suggest enhanced restoration apply catchment scale approach accounting connectivity availability source populations low intensity monitoring performed several decades evaluate restoration outcomes
metaphyseal changes rickets child abuse related fractures may difficult distinguish therefore important follow standardized procedure order detect mineralization defects skeleton differentiate healing fractures present typical post mortem case rickets year old boy different diagnostic tools applied confirm condition autopsy rachitic rosary seen vitamin insufficiency found laboratory analyses metaphyseal fraying radiography accumulation non mineralized bone osteoid undecalcified histological preparations led correct diagnosis case shows appropriate methodology use undecalcified bone preparations paramount importance detect mineralization defects moreover case involved combination rickets child abuse situation often complex neglect abuse may lead vitamin insufficiency
background people multiple sclerosis high risk osteoporosis fractures poor vitamin status risk factor vitamin supplementation recommended prevent progression maintain bone health methods assessed effect vitamin weekly compared placebo biochemical markers bone metabolism persons relapsing remitting multiple sclerosis results serum levels hydroxyvitamin doubled vitamin group parathyroid hormone decreased vitamin group compared placebo group week week however effect bone formation measured procollagen type propeptide pinp bone resorption measured terminal cross linking telopeptide type collagen ctx neither pinp ctx predicted bone loss baseline week conclusions findings corroborate previously reported lack effect weekly high dose vitamin supplementation bone mass density patients suggest vitamin supplementation prevent bone loss persons vitamin deficient
work extended version alam lou tillich eds international workshop coding cryptography wcc proposed first code based group signature new group signature scheme present numerous advantages existing post quantum constructions even competes terms properties pairing based constructions allows add new members lifetime group dynamic plus appears scheme might extended traceable signature according definition kiayias cachin camenisch eds advances cryptology eurocrypt kty model handling membership revocation security based relaxation model bellare topics cryptology rsa bsz model verifying properties anonymity traceability non frameability main idea scheme consists building offset collision two syndromes associated two different matrices random one enables build random syndrome chosen small weight vector trapdoor matrix syndrome decoding problem permits find small weight preimage previous random syndrome fixed syndrome added two small weight vectors constitute group member secret signing key whose knowledge proved thanks variation stern authentication protocol applications consider case code based cfs signature scheme nicolas advances cryptology asiacrypt courtois finiasz sendrier one denotes number group members cfs leads signatures public keys sizes along work also introduce new kind proof knowledge testable weak zero knowledge twzk implicitly covered short version paper alam lou tillich eds international workshop coding cryptography wcc twzk proofs appear particularly well fitted context group signature schemes allows verifier test whether specific witness used without learning anything proof random oracle model rom ensure security scheme defining one syndrome decoding problem new code based problem related syndrome decoding problem berlekamp ieee trans inf theory
objective paper assess potential energy savings water sewerage services means site integratedwater sewage management strategies low income households florianopolis brazil site water efficiency measures include reclamation gray water rainwater use thewater energy saving potential strategies studied energy intensities compared centralized water sewerage services furthermore water consumption pattern low income households empirically determined using smart meters rainwater supply estimated using computer program netuno water supply sewage reduction potential graywater systemswere determined using theoretical method average gray water rainwater supply capacities equivalent total water consumption households respectively regard energy savings rainwater harvesting energy intensive strategy kwh followed centralized systems kwh whereas gray water energy efficient strategy kwh findings suggest alternative water sewerage services may promote energy savings comparison centralized ones concomitant reduction sewage production achieved
china central government released ambitious plan tackle nation water pollution crisis however inhibited lack data particularly groundwater compiled analyzed water quality classification data publicly available government sources revealing scale extent crisis also compiled nitrate data shallow deep groundwater range literature sources covering china groundwater systems comprehensive national scale assessment yet nitrate pollution levels exceeding epa maximum contaminant level occurs percentile shallow aquifers deep karst aquifers isotopic compositions groundwater nitrate delta delta values ranging parts per thousand parts per thousand parts per thousand parts per thousand respectively indicate many nitrate sources including soil nitrogen agricultural fertilizers untreated wastewater manure locally show evidence nitrification data clear contaminated groundwater ubiquitous deep aquifers well shallow groundwater surface water deep aquifers contain water recharged tens thousands years present long widespread anthropogenic nitrate contamination groundwater therefore likely contaminated due rapid bypass flow along wells conduits addressing issue well condition urgently needed stop pollution china deep aquifers china important drinking water sources china new point water pollution plan addresses previous shortcomings however control remediation deep groundwater pollution take decades sustained effort published elsevier ltd
background seasonal affective disorder sad subtype recurrent depression involving major depressive episodes fall winter months remit spring central public health challenge management sad prevention winter depression recurrence light therapy established best available acute sad treatment however long term compliance daily first symptom spontaneous springtime remission every fall winter season poor time limited alternative treatments effects endure beyond cessation acute treatment needed prevent annual recurrence sad methods design nimh funded level randomized clinical trial test efficacy novel sad tailored cognitive behavioral group therapy cbt head head comparison next winter outcomes project designed test clinically meaningful difference cbt depression recurrence next winter primary outcome concurrent two arm study randomize currently symptomatic community adults major depression recurrent seasonal pattern cbt weeks treatment initial winter participants followed subsequent summer next winter two winters later key methodological issues surround timing study procedures predictably recurrent time limited disorder focus long term outcomes discussion chosen design answers primary question whether prior exposure cbt associated substantially lower likelihood depression recurrence next winter design test relative contributions cognitive behavioral treatment components nonspecific factors cbt outcomes adequately powered test differences equivalence cells treatment endpoint alternative designs addressing limitations would required patients increased costs reduced power detect difference primary outcome
essay analyzes link mobilization tribalism developed anbar awakening anbar awakening exposed anbari tribal structure deeply entrenched complex network deployed mobilize support generate behavior would achieve advantageous strategy position fight qaeda although description supports david kilcullen tribal society model rules awakening movement restored tribal network hardly explored counter insurgents value opportunity essay therefore draws narratives anbari sheikhs analyze properties tribalism culture identity problem solving non linear social network demonstrates paradigm mobilization anbari tribesmen valid indicator security link mobilization tribalism anbar awakening therefore strategically develops intervene social life address security locally
background drought stress tolerance crop improvement important goal worldwide drought complex trait vital understand complex physiological biochemical molecular mechanisms drought tolerance tackle effectively osmotic adjustment oxidative stress management osm cell membrane stability cms major components cellular tolerance drought stress current study explored molecular basis osm drought tolerant rice variety nagina compared popular drought sensitive rice variety drought imposed reproductive stage understand parental polymorphisms correlate superiority nagina tolerant bulk populations drought results generated recombinant inbred lines ril contrasting parents nagina focussed spikelet fertility terms correlation osm important component drought tolerance nagina based drought stress correlations yield related traits used superoxide dismutase sod glutathione reductase ascorbate peroxidase apx activity assays establish relationship osm genes tolerant sensitive lines among osm enzymes studied significant positive correlation single plant yield spy drought stress also positively correlated apx negatively sod interestingly none enzyme morphology correlations significant irrigated control genome wide snp analysis genes encoding osm enzymes identified functional polymorphisms parents identified superior alleles using network analysis osm genes rice identified genes central osm network conclusions biochemical morphological data snp analysis superiority nagina spikelet fertility drought stress superior alleles sod sod sodcc soda grcp rather apx superior allele apx nagina bypass apx directly interacting soda nine genes present central network nagina superior alleles propose nagina tolerance could mainly soda reactive oxygen scavenger mitochondria directly associated spikelet fertility
objective research crime victimisation mentally ill focused middle aged cohorts long standing illness functional disability rates correlates victimisation young cohorts largely unknown methods participants aged years attending headspace centres australia consented clinical interview provided self reported data regarding lifetime victimisation results quarter sample reported crime victimisation including experienced violent victimisation mainly physical sexual assault non violent crime forms victimisation associated illicit substance use sexual orientation young adult age male gender specifically associated non violent victimisation participants reported violent victimisation significantly impaired functionally clinically reporting non violent victimisation victimisation conclusions young people mental ill health vulnerable criminal victimisation particularly violent assaults although lifetime rates victimisation substantially lower observed older cohorts serious mental illness effective early intervention address modifiable factors may reduce risk victimisation
incremental forming new metal forming process used great success manufacturing sheet metal parts complex shapes suitable special manufacturing process automotive industry knowledge provided graduate level manufacturing engineering programmes usually lacks integrated approach order train specialist incremental forming graduate level special chapters introduced specific courses paper presents details competences required manufacturing engineers manage industrial implementation incremental forming process provided students lucian blaga university sibiu
triarchic model psychopathy patrick fowles krueger comprises phenotypic domains meanness disinhibition boldness ongoing controversy surrounds relevance boldness conceptualization assessment psychopathy current study undergraduate students completed triarchic psychopathy measure patrick examine association boldness host theoretically relevant external criteria boldness generally unrelated either prosocial harmful criteria boldness rarely provided incremental value interacted meanness disinhibition respect external criteria curvilinear effects boldness rarely emerged findings suggest boldness might central construct definition psychopathic personality disorder implications edition diagnostic statistical manual mental disorders american psychiatric association psychopathic specifier discussed
background perspective users taken account evaluation web based health interventions assessing users satisfaction intervention receive could enhance evidence intervention effects thus need valid reliable measures assess satisfaction web based health interventions objective objective study analyze reliability factorial structure construct validity client satisfaction questionnaire adapted internet based interventions csq methods psychometric quality csq analyzed user samples separate randomized controlled trials evaluating web based health interventions one depression prevention intervention sample stress management intervention sample first underlying measurement model csq analyzed determine internal consistency factorial structure scale measurement invariance across groups tested multigroup confirmatory factor analyses additionally construct validity scale examined comparing satisfaction scores primary clinical outcome results multigroup confirmatory analyses scale yielded one factorial structure good fit root mean square error approximation comparative fit index standardized root mean square residual showed partial strong invariance across samples scale showed good reliability indicated mcdonald omegas sample sample significant correlations change depressive symptoms perceived stress demonstrated construct validity scale conclusions proven internal consistency factorial structure construct validity csq indicate good overall psychometric quality measure assess user general satisfaction web based interventions depression stress management multigroup analyses indicate robustness across different samples thus csq seems suitable measure consider user perspective overall evaluation web based health interventions
introduction sacral neuromodulation snm remains one effective treatments refractory bladder bowel dysfunction however snm associated frequent need surgical intervention many cases failed battery rechargeable snm system manufacturer reported battery life years entered post market clinical testing europe yet approved clinical testing united states areas covered review existing neuromodulation technologies treatment lower urinary tract bowel dysfunction explore limitations available technology addition discuss implantation technique device specifications programming rechargeable snm system detail lastly present existing evidence use snm bladder bowel dysfunction evaluate anticipated trajectory neuromodulation technologies next five years expert commentary rechargeable system snm welcome technological advance however surgical revision related battery changes uncommon therefore rechargeable system would expected reduce costs eliminate ongoing maintenance associated neuromodulation matter apparent benefits new technologies require extensive post market monitoring ensure safety efficacy
irrigation service provided agricultural crops order improve yields also rare situation location costumers roots known heterogeneity water delivery system soil effects water distribution non uniformity soil plant conditions agricultural field complicates decision making parameters regarding irrigation management place sensors many sensors needed much irrigate many aspects non uniformity studied past decades including soil hydraulic properties tillage history irrigation method sensor location measured volume one aspect relatively neglected plant roots affect variability work focus effect growing roots variability tensiometer measurements corn seeds sown pre designed experimental plot consisted three distinct soils sand sandy loam clay create high variation investigated conditions subsurface drip irrigation installed plot drippers center line wrapped geotextile create geotextile drip interface gdi volume preferred conditions root growth tensiometers installed gdi gdi treatment away drip lines treatment matric head monitored throughout season weekly averaged coefficient variation gdi treatment decreased corn plants grew soil type entire plot time passed corn plants grew peaks due irrigation duration high decreased increasing influence root water uptake fluxes measured volume harvest returned initial values tensiometers showed higher values gdi tensiometers last week growth harvest tensiometer measurements decreased contrary trend gdi tensiometers results point major influence roots matric head variability first decreasing variability time second effect tensiometer location since gdi tensiometers located volumes high root density influence major consequences regarding methodology tensiometer measurements represent agricultural field might provide means global guidelines tensiometer placement irrigation management elsevier rights reserved
background internet become major tool patients search health related information communicate health currently lack data patients psychiatric disorders access use internet search information mental health study aimed assess patients followed psychiatric disorder schizophrenia bipolar disorder mood anxiety disorder substance related addictive disorders eating disorders prevalence internet access use patient expectations needs regarding use internet search mental health information depending psychiatric disorder methods conducted cross sectional study may july patients receiving psychiatric care hospitals region centre france used multivariate logistic regression adjusted age gender socio educational level professional status compare use expectations needs regarding internet based information patient psychiatric disorder items self administered questionnaires function psychiatric disorders identified patients clusters multiple correspondence analysis ascending hierarchical classification results although population accessed internet home prevalence internet access varied depending type psychiatric disorder much related limited access computer low income lack interest internet patients used internet interested access reliable internet based information health used internet search internet based health information psychiatric disorder found important differences terms expectations needs depending patient psychiatric disorder higher interest internet based information among patients bipolar disorder substance related addictive disorders eating disorders identified three clusters younger patients depressive anxiety disorders higher internet access internet use older patients low socio economical status low internet access internet use patients receiving long term care schizophrenia low internet access internet use conclusion patients psychiatric disorders reported average use needs expectations internet based health information comparable overall population however internet use needs expectations internet based mental health information differed patients depending psychiatric disorder internet based information communication mental health designed specifically psychiatric disorder elsevier masson sas rights reserved
article presents results experiments carried discover impact memory effect computing time series runs conducted execute sequential parallel algorithm solving system linear equations sle steepest descent method quantitative evaluation parallel algorithm realization exponents different ranks sle solving given dependences factors impact computing time detected parallel computing implemented distributed computing system programmable structure novosibirsk state technical university computer engineering department
uncontrolled studies show fatigue anorexia depression mortality associated low testosterone men cancer testosterone replacement improves quality life diminishes fatigue patients non cancer conditions primary objective evaluate effect testosterone replacement fatigue hypogonadal males advanced cancer functional assessment chronic illness therapy fatigue subscale facit fatigue day randomized double blinded placebo controlled trial outpatients advanced cancer bioavailable testosterone edmonton symptom assessment scale eligible intra muscular testosterone sesame seed oil placebo administered every days achieve levels sixteen placebo testosterone treated subjects evaluable statistically significant difference found facit fatigue scores arms placebo testosterone sexual desire inventory score performance status improved testosterone group fatigue subscale scores significantly better treated testosterone day four weeks intramuscular testosterone replacement hypogonadal male patients advanced cancer significantly improve quality life larger studies longer duration warranted
accurate segmentation bone human skeleton useful many medical disciplines results bone segmentation could facilitate bone disease diagnosis post treatment assessment support planning image guidance many treatment modalities including surgery radiation therapy medium level medical image processing task accurate bone segmentation facilitate automatic internal organ segmentation providing stable structural reference inter intra patient registration internal organ localization even though bones images visually observed minimal difficulty due high image contrast bony structures surrounding soft tissues automatic precise segmentation individual bones still challenging due many limitations images common limitations include low signalto noise ratio insufficient spatial resolution indistinguishable image intensity spongy bones soft tissues study novel automatic method proposed segment major individual bones human skeleton upper legs images based articulated skeleton atlas reported method capable automatically segmenting major bones including vertebrae ribs traversing hierarchical anatomical tree using rigid deformable image registration degrees freedom femora humeri modeled support patients different body limb postures segmentation results evaluated using dice coefficient point surface error pse manual segmentation results ground truth results suggest reported method automatically segment label human skeleton detailed individual bones high accuracy overall average dice coefficient average pses mandible cervical vertebrae thoracic vertebrae pelvis bones
importance chronic hepatitis infection significant world population infected least one extrahepatic manifestation hcv patients makes prognosis mortality worse pathomechanisms included cryoglobulin production immunmechanisms direct viral effects authors summarize main extrahepatic manifestations well treatment possibilities aim draw attention colourful infection order improve recognition era new effective direct antiviral agents
much attention given estimating cement related emissions china however scant explicit systematical exploration done regional national emission volumes aim work therefore provide improved bottom spatial integration system relevant emissions factory level allow accurate estimation emissions cement production based system sampling data cement production lines integrated regional national level information integration results showed ton clinker produced process fuel electricity emissions accounted respectively volume emissions clinker cement production reached respectively discrepancy identified clinker emission factors relevant two main production processes new suspension preheating pre calcining kiln nsp vertical shaft kiln vsk probably relevant energy efficiency two technologies analysis spatial characteristics indicated spatial distribution clinker emission factors mainly corresponded nsp process discrepancy spatial pattern largely complied economic population distribution pattern china study could fill knowledge gaps provide role players useful spatial integration system facilitate accurate estimation carbon corresponding regional mitigation strategies china
background contemporary descriptions classical hodgkin lymphoma chl lacking sub saharan africa human immunodeficiency virus hiv epstein barr virus ebv prevalent methods describe prospective chl cohort inmalawi enrolled patients received standardized treatment evaluation including hiv status ebv testing tumors plasma results among patients confirmed chl themedian agewas years range years male sixteen patients stage iii symptoms performance status impairment twenty three patients symptoms months received empiric antituberculosis treatment anemia common median hemoglobin range improved treatment children adults werehiv allhiv patients antiretroviral therapy median months range months median count cells range cells four undetectable hiv ebv present tumor specimens including hiv hiv baseline plasma ebv dna detected patients median viral load range logcopies subsequently declined patients months overall survival confidence interval progression free survival baseline plasma ebv dna persistent viremia treatment associated poorer outcomes conclusion chl malawi characterized delayed diagnosis advanced disease cases ebv associated one third adults hiv despite resource limitations month outcomes good
theory methods obtain reduced order models moment matching input output data presented algorithms estimation moments linear nonlinear systems proposed estimates exploited construct families reduced order models models asymptotically match moments unknown system reduced conditions enforce additional properties matching prescribed eigenvalues upon reduced order model provided discussed computational complexity algorithms analyzed use illustrated two examples compute converging reduced order models linear system describing model building provide exploiting approximation moment nonlinear planar reduced order model nonlinear converter author published elsevier ltd
background paucity literature direct physicians prescribing immunomodulators patients severe atopic dermatitis objective survey systemic agent prescribing practices severe childhood among clinicians united states canada methods treatment severe atopic dermatitis children taskforce treat canada project pediatric dermatology research alliance pedra developed online multiple response survey assess clinical practice gather demographic information details systemic agent selection identify barriers use patients recalcitrant pediatric results total members society pediatric dermatology completed survey used systemic treatment severe pediatric first line drugs choice cyclosporine methotrexate mycophenolate mofetil commonly used second line agents methotrexate mycophenolate mofetil azathioprine commonly cited third line agent main factors discouraged use systemic agents side effect profiles perceived risks long term toxicity limitations investigation sequence systemic medications combination systemic therapy limited recall bias may affected results conclusion great variation exists prescribing practices among american canadian physicians using systemic agents treatment pediatric
depression major health problem oxidative stress inflammation inextricably connected pathophysiology coenzyme coq important anti oxidant compound anti inflammatory neuro protective properties study designed investigate hypothesis coq anti oxidant anti inflammatory potentials alleviate depressive like behavior restoring balance tryptophan catabolites kynurenine serotonin toward serotonin pathway regulation hippocampal indoleamine dioxygenase ido depressive like behavior induced chronic unpredictable mild stress cums protocol including food water deprivation cage tilting reversed light cycle etc male wistar rats randomly divided five groups control cums cums coq day respectively groups coq effects different behavioral biochemical tests analyzed coq showed significant antidepressant efficacy evidenced significantly decreased stress induced changes forced swimming challenge open field test well attenuating raised corticosterone level adrenal glands weight anti oxidant effect coq exhibited ability significantly reduce hippocampal elevated malondialdehyde hydroxynonenal levels elevate reduced glutathione catalase levels coq significantly reduced different pro inflammatory cytokines levels including interleukin beta tumor necrosis factor alpha suppressed hippocampal ido subsequent production kynurenine enhanced hippocampal contents tryptophan serotonin immunohistochemical analysis revealed coq able attenuate elevated microglial elevate astrocyte glial fibrillary acidic protein compared cums group coq exhibited antidepressant like effects rats exposed cums could attributed ability reduce ido leading shift balance kynurenine serotonin toward serotonin pathway
aim study show presence small quantity konjac glucomannan kgm potato starch suspension increased stability carvacrol trapping purpose several freeze thaw cycles used accelerate ageing product consequently drastically destabilize gels induce syneresis stability carvacrol trapping evaluated quantification carvacrol syneresis liquid stability starch gel structure studied microscopic macroscopic scale moment addition carvacrol presence kgm effect stability carvacrol trapping structure gel kgm promoted amylose retrogradation slowed amylopectin retrogradation stability potato starch gels improved addition small quantity kgm showed cryo protectant behaviour new method characterize micro macrostructure sem images processing also proposed processing microscopy images done using generalized fourier descriptors allowed characterization sample carvacrol addition lowered physical stability gel larger pores increased syneresis contrary kgm addition increased size pores prevented formation large pores reduced syneresis stable system obtained addition carvacrol end heating konjac glucomannan potato starch gel elsevier ltd rights reserved
considerable overlap symptoms patients borderline personality disorder bpd schizotypal personality disorder stpd complicates personality diagnostics yet little known level psychodynamic functioning personality disorders psychodynamic assessment procedures may specify personality characteristics relevant differential diagnosis treatment planning cross sectional study explored differences similarities level personality functioning psychodynamic features patients severe bpd stpd total patients bpd patients stpd compared regarding level personality functioning general assessment personality disorder current quasipsychotic features schizotypal personality questionnaire psychodynamic functioning developmental profile interview developmental profile inventory dpi questionnaire groups patients showed equally severe impairments level personality functioning presence current quasipsychotic features assessed interview significant differential psychodynamic patterns found primitive levels functioning moreover subjects bpd significantly higher scores adaptive developmental levels however self questionnaire dpi able elucidate differences conclusion study found significant differences psychodynamic functioning patients bpd stpd assessed interview complicated diagnostic cases personality assessment psychodynamic interviewing enhance subtle essential differentiation bpd stpd
lymphoma eyelid constitutes ocular adnexal lymphoma previously published cases lymphomas eyelid cell origin cell origin frequent cell lymphomas extranodal marginal zone lymphoma cases diffuse large cell lymphoma cases cell lymphomas frequently mycosis fungoides cases extranodal natural killer cell nasal type lymphoma cases primary cutaneous anaplastic large cell lymphoma cases distribution differs distribution ocular adnexal lymphoma cutaneous lymphoma majority subtypes occur elderly patients except lymphoblastic lymphoma cell cell origin burkitt lymphoma occur children adolescents several subtypes male predominance including peripheral cell lymphoma burkitt lymphoma lymphomatoid papulosis female predominance signs cell cell lymphomas tumor swelling eyelid ulceration erythema occur frequently among patients cell lymphoma radiotherapy without surgery treatment choice low grade solitary lymphomas whereas chemotherapy without adjuvant treatment treatment choice high grade disseminated lymphomas majority subtypes especially low grade subtypes good prognosis recurrences progression subtypes including mycosis fungoides poorer prognosis extranodal natural killer cell lymphoma nasal type exceedingly poor prognosis elsevier inc rights reserved
differences noise density values mdct images obtained using ultra low doses fbp asir mbir may possibly affect implant site density analysis aim study compare density noise measurements recorded dental implant sites using ultra low doses combined fbp asir mbir cadavers scanned using standard protocol four low dose protocols scans reconstructed using fbp asir asir mbir either bone standard reconstruction kernel density mean hounsfield units hus alveolar bone noise levels mean standard deviation hus recorded datasets measurements compared paired tests two way anova repeated measures significant differences density noise found reference dose fbp protocol almost test combinations maximum mean differences bone kernel standard kernel noise bone kernel standard kernel decreasing radiation dose increased density noise regardless reconstruction technique kernel effect reconstruction technique density noise depends reconstruction kernel used aeuro cent ultra low dose mdct protocols allowed reductions dose aeuro cent decreasing dose generally increased density noise aeuro cent effect irt density noise varies reconstruction kernel aeuro cent accuracy low dose protocols interpretation bony anatomy known aeuro cent effect low doses accuracy computer aided design models unknown
study guided research question personality traits character traits situational factors interaction necessary explain helping behavior undergraduates scores agreeableness scale big five inventory kindness scale values action inventory examined conjunction experimentally induced positive neutral negative mood via false feedback bogus intelligence test number spilled pencils participants helped retrieve mishap measure helping kindness significantly predicted helping behavior neither feedback condition agreeableness significantly related helping interactions kindness agreeableness feedback conditions non significant results highlight stronger contribution helping behavior trait kindness trait agreeableness situational factors elsevier ltd rights reserved
histamine biogenic amine synthetized released mast cells acts vasodilator several pathologic processes namely allergies conjunctivitis role cancer fully understood high levels histamine associated bivalent behavior regulation several tumors cervical ovarian vaginal uterine vulvar colorectal cancer melanoma promoting inhibiting growth histamine receptors present vast group cells including tumor cells making sensitive histamine variations work review role mast cells histamine cancer development possibility use antihistamines clinical management disease elsevier inc rights reserved
increase violence children diagnosed social problem costa rican society article focuses presence ideological bias opinion writings local newspapers nacion diario extra explains visions sources ideological contribute end violence effective promotion childrens human rights order avoid violence must develop pro children cultural change complex multi institutional social networking children autonomy critic family institution
objectives aimed improve limitations encountered previously published studies compare mortality patients acute myocardial infarction ami treated either fibrinolysis primary percutaneous coronary intervention ppci methods embase medline cochrane databases searched trials comparing fibrinolysis ppci patients ami endpoint assessed analysis cause mortality therefore hospital short term mid term long term mortality analyzed whereby odds ratios confidence intervals cis calculated using revman results total patients obtained studies involving trials included results analysis showed fibrinolytic therapy associated significantly higher hospital mid term mortality respectively short term long term mortality also significantly higher fibrinolytic group respectively compared ppci conclusion analysis patients showed significantly higher mortality rate associated fibrinolysis compared ppci patients ami hence compared fibrinolysis ppci expected preferred method revascularization patients ami especially pci capable centers copyright wolters kluwer health inc rights reserved
years research numerous studies shown injection drug use associated wide range adverse health outcomes drug overdoses drug related suicidal behaviours comorbid psychiatric disorders blood borne pathogens infectious diseases traumas review explores new trends prominent issues associated injection drug use dynamic nature injection drug use underlined examining recent trends changing patterns canada high income countries three research topics could contribute development comprehensive prevention intervention strategies aimed people inject drugs also discussed risk behaviours associated injection prescription opioids binge injection drug use mental health problems determinants injection risk behaviours
background sublingual immunotherapy slit house dust mites hdm preparation recently proven beneficial treating allergic rhinitis asthma however report regarding efficacy safety slit korean patients atopic dermatitis objective intended investigate efficacy safety slit korean patients methods total patients immunoglobulin ige proven hdm sensitization class recruited eczema area severity index easi score total serum ige level specific ige assays dermatophagoides pteronyssinus farinae adverse effects recorded follow responder defined patient improvement easi score slit results twenty three patients continued slit months whereas patients dropped exacerbation dermatitis patients lost follow average duration slit treatment months range similar months easi scores reduced significantly months treatment compared baseline total patients determined responders slit months total specific ige serum levels significantly reduce slit patients experienced serious adverse events exception two patients developed transient lip tongue swelling conclusion study demonstrated slit hdm extracts effective tolerable korean patients controlled long term trials required reinforce current results
application speed control using adjustable speed drives asds industrial applications contain fans pumps enables improved energy efficiency conservation offers improved process control however success application terms energy conservation improved process control depends upon tempering enthusiasm disciplined logic order maximize benefits done understanding requirements process understanding use asd within process understanding potential risk success outcome use speed control necessarily equate energy savings improved process control judicious application speed control provides successful outcome paper consider proven methodologies may used selecting suitable applications asds
aims determine prevalence international normalized ratio inr findings outside normal range hospital emergency department patients vitamin antagonists vkas identify factors associated abnormal anticoagulant levels patients methods observational cross sectional multicentric study hospital emergency departments included convenience sample patients vka treatment inr levels record sought emergency care complications unrelated anticoagulant treatment results included patients mean age years women atrial fibrillation found inrs outside reference range multivariate analysis showed changes patients long term medications independently associated nontherapeutic inr results odds ratio conclusions patients vka treatment come hospital emergency departments complaints unrelated anticoagulant therapy inr values outside normal range changes patient usual medications significantly associated nontherapeutic inr findings
background sex chromosome aneuploidies occur approximately one live births frequent abnormalities turner syndrome xxx triple xxy klinefelter syndrome xyy prevalence males one extra sex chromosome xxyy xxxy less common however literature provides little information cognitive behavioural phenotype natural history disease report clinical neurocognitive social cognitive psychiatric characterization patient xyyyy syndrome case presentation patient presented complex phenotype including particular cognitive profile intellectual deficiency autism spectrum disorder asd limited interests moreover social anxiety disorder selective mutism separation anxiety disorder observed dsm criteria mini assessment conclusion admitted xyyyy unique medical neurodevelopmental behavioural characteristics interestingly asd common groups chromosome aneuploidy clinical report suggests understanding cognitive social functioning patients may provide new insights possible therapeutic strategies cognitive remediation social cognitive training
vision integrated computational materials engineering icme revolutionize advancement new materials integrating materials information process structure properties performance captured multiscale materials modeling product development life cycle enabling complex vision requires development cyberinfrastructure acts global knowledge base providing plethora disparate materials mechanics research information community large recent years many web portals developed including engineering virtual organization cyber design evocd effort form global cyberinfrastructure icme furthermore equally important well challenging educate engineering workforce order able collaborate exchange materials knowledge leveraged developed global accomplish vision icme therefore propose new learning methodology follows traditional learning approach teaching theoretical concepts icme paradigm simultaneously engaging modem collaborative approach teaching practical aspects multiscale modeling modular fashion using resources accessible online icme evocd methodology used formulating new course taught part fall graduate coursework mississippi state university goal methodology embraced course provide students basic skills take advantage computational tools state art software artifacts provided evocd conducting simulations bridging procedures quantifying structure property relationships materials multiple length scales successful completion assigned projects students published multiscale modeling learning outcomes icme wiki facilitating easy assessment student achievements embracing qualities set abet engineering accreditation board
background aim study investigate contraceptive non use associated factors socio demographics sexual behaviour internal assets mental health among undergraduate university students countries methods using anonymous questionnaires data collected undergraduate university students mean age universities countries results total sample undergraduate university students reported sexually active past months sexually active reported never among male among female students using contraceptives past months multivariate regression analysis among men women younger age religious affiliation hindu among women muslim intrinsic religiosity sexually protective behaviour associated contraceptive non use lack internal assets among men low life satisfaction lack personal control among women low personal mastery among women depressive symptoms among men ptsd symptoms associated contraceptive non use conclusion low contraceptive use found several factors identified associated contraceptive non use may help guide intervention efforts
functional dyspepsia common significantly impairs quality life symptoms considered originate gastroduodenal region classified rome criteria disorders brain gut interaction without structural alteration however apparent number syndromes epigastric pain syndrome bothersome epigastric pain epigastric burning postprandial distress syndrome bothersome postprandial fullness early satiation wide ranging symptoms severity origin troublesome symptoms considered result disrupted gastroduodenal neuropathophysiology complexity syndrome indicates must different triggers supported limited efficacy many treatments available current research based evidence association suggests duodenal contents including duodenal microbiome pathogens allergy may triggers recent studies also shown systemic responses increased circulating lymphocytes elevated proinflammatory cytokines subtle inflammation duodenum may accompany onset persistence symptoms inflammatory phenotype characterized innate inflammation eosinophil infiltrate duodenum postprandial distress syndrome routine histopathology practice quantify cells status yet appreciated inflammatory condition thus functional becoming inflammatory breakthrough understanding functional necessarily mean subtle pathology may improve therapeutic options currently aimed symptom relief rather targeted underlying pathology
objective patient family centered care pfcc recognizes family integral partner high quality clinical decision making important improving children health care studies examining pfcc disparities general pediatric population however sparse use methodology might mislead readers overestimate effect sizes high prevalence high quality pfcc address issues using improved statistical modeling conceptually grounded disparity domains recent data methods study examined children medical expenditure panel surveys pooled cross section least health care visit previous year eligible pfcc questions used robust adjusted multivariable poisson regression estimate prevalence rate ratios closer estimates true risk ratios highly prevalent outcomes measures high quality pfcc composite measure results overall pfcc quality prevalences high ranging across pfcc measures parents reporting composite measure multivariable analyses lower prevalence high quality pfcc consistently observed among publicly insured children relative privately insured prevalence rate ratios ranging across pfcc measures composite children living families poverty line children poverty line times prevalence high quality pfcc across pfcc measures composite conclusions although prevalence rate ratio methodology revealed smaller perhaps clinically insignificant disparities children pfcc quality previously portrayed nonetheless several statistically significant disparities remain consistent disparities identify vulnerable pfcc quality publicly insured impoverished children
objective evaluate efficacy safety biosimilars anti tumor necrosis factor tnf alpha agents compared reference agents immune mediated diseases methods electronic databases searched randomized controlled trials rcts assessing efficacy safety biosimilars anti tnf alpha agents compared reference agents patients various immune mediated diseases outcomes rates clinical response adverse events among patients treated biosimilars compared reference agents additionally occurrence anti drug antibodies use biosimilars compared reference agents results nine studies reporting outcomes patients rheumatoid arthritis ankylosing spondylitis identified infliximab adalimumab etanercept rcts diseases found biosimilars infliximab showed similar rates clinical response compared reference agent frequency anti drug antibody adverse events similar except slightly significantly higher risk upper respiratory tract infections biosimilar confidence interval biosimilar adalimumab showed differences among outcomes compared reference agent biosimilars etanercept showed differences clinical response frequency adverse events showed significantly lower rate anti drug antibodies weeks conclusion present study biosimilars anti tnf alpha agents overall comparable efficacy safety profile compared reference agents supporting use conditions elsevier ltd rights reserved
background aim study develop minimally invasive hydrogel system release strontium ions element shown increase osteoblast proliferation prohibit bone resorption controlled manner methods srco selected salt choice due potential acid neutralization reaction srco degradation products methoxy polyethylene glycol poly lactic glycolic acid mpeg plga namely lactic acid glycolic acid srco incorporated mpeg plga hydrogel system assessed gelation properties drug release biocompatibility results srco incorporation hydrogel srco ratios compromise thermosensitivity mpeg plga hydrogels furthermore incorporation srco ratio prevented copolymer self catalysis decreased hydrogel weight loss vitro days day time frame zero order strontium release observed correlated hydrogel degradation acidity addition srco also improved vivo hydrogel biocompatibility due moderation acidic microenvironment amelioration flammatory response conclusions results showed described system suitable extended release strontium exhibits potential localized treatment osteoporosis bone void filler
work present interactive collaborative object manipulation system using shelf mobile devices coupled augmented reality technology allows multiple users collaborate concurrently scene user interested participating collaboration uses mobile device running android desktop laptop working tandem scene visualized user desktop system changes scene viewpoint object manipulation performed using mobile device object tracking multiple users collaborate object manipulation using laptop mobile device system leverages user knowledge common tasks performed current mobile devices using gestures built prototype system allows users complete requested tasks performed informal user study experienced researchers validate system
background many patients complain abdominal symptoms dairy products however clinical psychosocial factors associated self reported lactose intolerance sli assessed large studies particular data lacking lactase deficient populations prospective cohort study assessed prevalence risk factors sli chinese patients attending gastroenterology clinic methods consecutive patients completed questionnaires assess digestive health rome iii psychological state hads life event stress les food intake quality life representative sample completed genetic studies hydrogen breath testing hbt clinically relevant dose lactose key results sli present clinic patients functional abdominal symptoms genotype subjects small number novel snps lactase promoter region identified including appeared confer lactase persistence half patients completed lactose hbt reporting typical symptoms positive negative predictive values sli abdominal symptoms hbt respectively psychological state stress associated sli clinic patients sli impacted physical quality life associated reduced ingestion dairy products legumes dried fruit conclusions inferences lactase deficient population approximately half patients attending clinic functional gastrointestinal symptoms reported intolerance dairy products however sli predict findings lactose hbt independent psychosocial factors sli impacted quality life impacted food choices restrictions limited dairy products
background management allergic patients population becoming difficult increases complexity prevalence although general practitioners gps expected play important role care allergic patients often feel ill equipped task therefore aim study develop allergy management support system amss primary care methods literature review interviewing testing secondary primary care patients allergy history questionnaire constructed allergists dermatologists gps researchers based primary care specialists allergy guidelines clinical knowledge patterns amss questionnaire responses specific immunoglobulin sige test outcomes used identify diagnostic categories develop corresponding management recommendations validity amss investigated comparing specialist gold standard amss diagnostic categories results two page patient completed amss questionnaire consists mainly multiple choice questions symptoms triggers severity medication based amss questionnaires sige test outcome patients approximately diagnostic categories allergic rhinitis asthma atopic dermatitis anaphylaxis food allergy hymenoptera allergy allergies identified corresponding management recommendations formulated agreement allergy specialists assessments amss conclusion using systematic approach possible develop amss allows formulation diagnostic management recommendations gps managing allergic patients amss thus holds promise improvement quality primary care increasing group patients
motion sensors getting light weighted low priced growing appetite accelerometer based approaches efficiently monitoring human activities paper proposes original feature selection approach based spectral distances given signal activity model new technique evaluated compared existing techniques literature study also investigates improvement classification performances brought heart rate data addition accelerometer data experimental dataset composed acceleration recordings eight volunteers performing five ambulation activities four wearable sensor units including ecg node employed response system three widely used classifiers nearest neighbors naive bayes decision tree reported along classification rates results reached overall recognition accuracy higher using single sensor acceleration data data results demonstrate spectral distances approach adopted accurately classify activities joint processing acceleration signals together signals increase classification accuracy compared case processing acceleration signals alone elsevier ltd rights reserved
molecular dynamics simulation uniaxial tension along performed study influence various surface defects initiation plastic deformation fracture gamma tial single crystals results indicate brittle fracture occurs perfect bulk surfaces edges detrimental strength materials provide dislocation nucleation site defects surfaces edges cause weakening various effects depending defect type size position orientation edge dimples influential gamma tial rods surface dimples dislocations nucleate edge rod dimples small dimple dislocation nucleation occurs dimples larger strain rate dependent critical size dislocations nucleated upon tension super dislocations burger vectors containing four partials effects surface scratches orientation shape sensitive scratches parallel loading direction little influence sharp ones perpendicular loading direction may cause crack thus avoided simulation also shows type surface defect would lower strength cause crack cases may facilitate dislocation nucleation improve ductility tial well controlled copyright editorial office journal materials science technology published elsevier limited
days three degree freedom dof cranes considered backbone industries mostly used picking placing heavy objects one place another place common part mostly cranes jib system two main tasks jib system movement trolley loading unloading payload safety crane mostly depends upon sub tasks cases number unwanted vibrations due undesirable initial jerks trolley results uneven operation crane jerks usually happened acceleration start deceleration end crane operation desirable develop control technique tries reduce theses initial trolley jerks providing reasonable input trolley moreover reduction jerks reduce payload vibrations results smooth operation crane research work implemented control technique payload vibration trolley position control jib system three dof crane gains controllers found two methods namely lqr pole placement performance controllers investigated matlab simulink results shows effectiveness tune lqr compared tune pole placement context settling time rise time trolley position payload vibrations former technique also helpful reduction payload vibrations payload load anti swing also improved overshoot trolley
dielectric properties spent adsorbent zinc sulfate investigated cavity perturbation technique mhz degrees approximately degrees two weight loss stages observed spent adsorbent thermogravimetric differential scanning calorimeter dsc analysis zinc sulfate decomposed zno znso zno degrees degrees microwave absorption capability znso increases increasing temperature declines zno generation account poor dielectric properties dielectric properties spent adsorbent dependent apparent density noticed interestingly linearly relationship room temperature three parameters increase gently degrees degrees sharp increase real part imaginary part found subsequently due volatiles release regeneration carbon material conductivity improved contributes electron conduction appearance relationship penetration depth temperature elaborate spent adsorbent excellent microwave absorber microwave absorption capability order zinc compounds zno znso znso zno heating characteristics suggest heating rate related dielectric properties materials pore structures spent adsorbent improved significantly surface smoother microwave regeneration elsevier rights reserved
clinicians make variety assessments clients judging personality traits making diagnoses variety methods available ranging observations structured interviews large body work demonstrates brief glimpse another nonverbal behavior variety traits inner states accurately perceived additionally thin slices behavior even future outcomes predicted accuracy certain clinical disorders parkinson disease facial paralysis disrupt nonverbal behavior may impair clinicians ability make accurate judgments certain contexts personality disorders anxiety depression suicide attempts outcomes detected others nonverbal behavior additionally thin slices predict psychological adjustment divorce bereavement sexual abuse wellbeing throughout life thus certain traits disorders judgments thin slice could provide complementary tool clinician toolbox
memories serve database self people often produce distorted memories support self concepts one surprisingly untested possibility cognitive dissonance may one mechanism people may misremember past tested hypothesis using induced compliance paradigm participants either chose forced write counterattitudinal essay supporting tuition increase afforded opportunity reduce dissonance via attitude shift denial responsibility reported memories experimental instructions initial attitudes assessed two days prior laboratory session participants chose write essay exhibited predicted attitude shift effect likely misremember initial attitudes experimental instruction forced write essay overall results provide evidence cognitive dissonance may yield memory distortion filling significant gap motivated cognition memory literatures
present theoretical experimental analysis model diffusion engineering innovations recently proposed cao yang particular mild realistic assumption innovation coefficients show unique solution defined whole set positive times always exist moreover numerical method solve model cao yang developed whose convergence proven theoretically shown direct simulation accurate fast finally experimental assessment model performed considering case satellite radio market analysis highlights model cao yang useful predict dynamics firms already present market well time evolution new start ups
present research examined effect starting turning performances subsequent swimming parameters comparing starting turning velocities swimming parameters emersion mid pool segments relating individual behaviour swimmers start turns subsequent behaviour swimming lap one hundred twelve performances fina world swimming championships analysed image processing system inthepool point start emersion swimming parameters elite swimmers substantially greater mid pool parameters except breaststroke races hand diminution swimming parameters observed turn emersion mid pool swimming except butterfly backstroke male races changes surface swimming kinematics generally related starting turning parameters although male swimmers develop faster starts seem achieve faster velocities emersion race analysts aware transfer momentum swimmers emerge underwater implications subsequent swimming kinematics especially male swimmers employ underwater undulatory techniques
paper dimensional sawada kotera model studied hirota bilinear method gauge transformation symbolic computation based alternative bilinear representation model bilinear backlund transformation three arbitrary constants derived via applying gauge transformation choosing suitable constant parameters three sets bilinear bts constructed among last set treated new bilinear denoted btiv hereby finally performing perturbation technique new bilinear namely btiv multisoliton solutions iteratively achieved example one two three soliton solutions explicitly given note formulas soliton solutions obtained hereby solving btiv different previous ones literature
objective methods correlation total testosterone levels exercise capacity metabolic echocardiographic parameters studied male subjects coronary artery disease cad different stages glucose tolerance results testosterone level lowest among diabetics compared prediabetics controls total abdominal adiposity highest subjects lowest testosterone independent adiposity fasting glucose insulin leptin higher among diabetic control groups lowest hbac values higher among diabetics lowest highest testosterone tertile controls prediabetic subjects lowest testosterone levels lowest hdl cholesterol levels controls also highest triglycerides association low testosterone level low maximal exercise capacity observed diabetics controls independent adiposity metabolic parameters low testosterone levels associated highest septal wall thickness among diabetics conclusion negative correlation low testosterone dysmetabolic features observed independent metabolic status low plasma testosterone seems indicator impaired maximal exercise capacity cardiac hypertrophy among cad patients type diabetes
sheppard mitchell psychol provide interesting data perception empathy focus cue validity could usefully expanded look cues used whether multimodal properties perception empathy relates first impressions
understanding expenditure patterns hospital emergency department use among individuals dementia crucial controlling medicare spending analyzed health retirement study data medicare claims stratified beneficiaries residence proximity death estimate medicare expenditures cause potentially avoidable hospitalizations visits analysis limited medicare fee service population age older compared people without dementia community residents dementia higher average expenditures hospital services nursing home residents dementia lower average expenditures cause hospitalizations decedents dementia lower expenditures without dementia last year life medicare expenditures individuals without dementia vary residential setting proximity death results highlight importance addressing needs specific population dementia many initiatives reduce hospital admissions focus people dementia
wake oscillator model considered proper semi empirical model qualitatively even quantitively assessing vortex induced vibration structure design stage however complexities parameter determination limit usage real engineering fields moreover kind model traditionally used describe experimental phenomena two dimensional cross section models gaps results two dimensional cross section model tests prototype responses three dimensional real structures filled paper detailed study wake oscillator model firstly presented demonstrates influences model parameters viv features described wake oscillator model new method conveniently identifying model parameters wake oscillator model proposed besides new procedure based wake oscillator model interpreting wind tunnel test results real structures also proposed results validated wind tunnel tests compared field measurements elsevier ltd rights reserved
data sharing information exchange among medical institutions requirement convenient effective data availability healthcare professionals patients paper characteristics medical data studied two mainstream technologies data storage medical information compared three strategies medical documents storage described detailed advantages disadvantages semi structured storage technology easier deploy much promising promote wider range structured methods combination central distributed data storage practical regional data sharing analysis suggests semi structural data storage technology combination central distributed data storage efficient fit well current situation china
purpose background although second generation antipsychotics used treat manage symptoms several psychiatric disorders data adverse effects developmental age limited aimof prospective observational study verify cardiovascular metabolic risk sample antipsychotic naive children adolescent patients starting risperidone therapy methods twenty two patients younger years recruited assessment included anthropometric data cardiovascular parameters blood tests ultrasonographic abdominal study results average follow period months statistically significant increases mean values waist circumference body mass index bmi bmi percentile bmi score total cholesterol prolactin found cardiometabolic parameters showed upward trend time subjects pubertal postpubertal stage female patients susceptible developing cardiometabolic changes moreover significant correlations changes anthropometric several metabolic parameters found tendency change constitution liver parenchyma distribution abdominal fat mass ultrasonographic abdominal study also evident conclusions sample several metabolic parameters showed sensitivity risperidone treatment parameters age dependent metabolic syndrome criteria used adults inappropriate children adolescents periodic clinical instrumental evaluations guidelines monitoring metabolic laboratory instrumental complications necessary perspective even long time second generation antipsychotics treatment children adolescents
lateral diffusion compartmentalization plasma membrane proteins tightly regulated cells thus studying processes reveal new insights plasma membrane protein function regulation recently space image correlation spectroscopy kics developed enable routine measurements diffusion coefficients directly images fluorescently tagged plasma membrane proteins avoided systematic biases introduced probe photophysics although theoretical basis analysis complex method implemented nonexperts using freely available code measure diffusion coefficients proteins kics calculates time correlation function fluorescence microscopy image stack fourier transformation image reciprocal space subsequently circular averaging natural logarithm transform linear fits correlation function yields diffusion coefficient paper provides step step guide image analysis measurement diffusion coefficients via kics first high frame rate image sequence fluorescently labeled plasma membrane protein acquired using fluorescence microscope region interest roi avoiding intracellular organelles moving vesicles protruding membrane regions selected roi stack imported freely available code several defined parameters see method section set kics analysis program generates slope slopes plot space time correlation functions diffusion coefficient calculated slope plot step step kics procedure measure diffusion coefficient membrane protein using renal water channel aquaporin tagged egfp canonical example
present study designed monitor predict land cover change lcc addition characterizing lcc dynamics baha region kingdom saudi arabia utilizing remote sensing gis cellular automata model markov moreover determine effect rainwater storage reservoirs driver expansion irrigated cropland eight landsat etm images analyzed ultimately utilized categorizing maps classified four main classes bare soil sparsely vegetated forest shrub land irrigated cropland quantification lcc analyzed categories showed bare soil sparsely vegetated largest classes throughout study period followed forest shrubland irrigated cropland processes lcc study area constant varied one class another two stages bare soil change increase stage decline stage construction rainwater harvesting dams region turning point bare soil change greatest increase observed irrigated cropland expense three categories effect extensive rainwater harvesting practices losses evident forest shrubland sparsely vegetated land first stage total area covered total area second stage forest shrubland witnessed significant increase irrigated cropland underwent greatest growth entire study period agriculture expansion reached zenith markov simulation predicts continuing upward trend irrigated cropland forest shrubland areas well downward trend bare soil sparsely vegetated areas spatial distribution prediction indicates irrigated cropland expand around reservoirs mountain areas validation result showed model successfully identified state land cover agreement actual projected cover output study would useful decision makers land use planners saudi arabia similar arid regions
background possible relationship periodontitis juvenile idiopathic arthritis jia mostly unknown common characteristics two diseases purpose study evaluate etanercept enbrel effects periodontal conditions children affected jia methods study three group patients selected first one represented jia subjects pharmacologic therapy etanercept enbrel second one composed subjects pharmacologic therapy drugs third one healthy subjects twenty subjects group selected subject two periodontal scores taken plaque index bleeding probing order check reliability method second registration performed groups one month statistic kruskal wallis test performed results average plaque index first group second group control group average bleeding index first group second group control group conclusions etanercept seems reduce periodontal inflammation children affected jia therapy
diet low poorly absorbed fermentable short chain carbohydrates fodmaps effective strategy manage symptoms irritable bowel syndrome ibs diet gained traction since original description australia years ago internationally accepted dietary management strategy ibs randomized controlled trials raised profile low fodmap diet become viable first line therapy ibs implemented dietitian guidance importantly diagnosis ibs confirmed commencement dietary approach skill set dietitian paramount success diet experience gastrointestinal disorder management consideration symptom types severity baseline fodmap intake overall nutritional content meal pattern vital assessment patient strict low fodmap diet deemed necessary initial period weeks research suggests strict long term low fodmap diet may negatively impact intestinal microbiome initial strict period follow dietitian conducted achieve overall goal relaxed fodmap restriction enables inclusion prebiotic fodmaps still maintaining symptom relief diet effective vast majority patients fails fodmaps reintroduced diet dietary non dietary approaches considered
sustainable water management crucial reduction water pollution floods new techniques investigated order avoid present future problems flood drought water contamination purpose low impact development best management practice lid bmp recently come stage storm water management vegetative swales green roofs bioretentions storm water wetlands rain barrels permeable asphalts pavements among lid bmps bioretention type lid implemented diminish adverse effects urbanization flood reducing peak flows surface thus managing storm water runoff aim study investigate hydrological performance bioretentions developing hydrological model based data obtained using experimental setup called rainfall watershed bioretention rwb hydrological model rwb rwb consists two main components rainfall runoff model kinematic wave theory used simulation surface runoff generated drainage area reaches bioretention inflow runoff bioretention flow model green ampt method unsteady rainfall employed improved incorporating effect ponding depth bioretention simulation outflow exit bioretention observed results hydrological model developed herein good agreement measured data obtained rwb experimental setup
enormous growth industrial applications using internet communication secure network prime objective survival organization network monitoring defence systems become integral part network security identifying preventing potential attacks intrusion detection prevention systems idps network based defence systems combines intrusion detection system ids firewall contrast ids idps proactive technique provides quick reactions potential threats attacks network well preventing attacks entering network current generation idps limitations performance effectiveness studies proven modern idps difficulties dealing high speed network traffic meeting current network requirements exist several research approaches find efficient idps nevertheless serious security privacy breaches still occur every day creating absolute necessity provide secure safe information security systems survey provides date comprehensive review state art idps based different accelerating techniques different detection algorithms types hardware optimizing algorithms match demand requirements high speed network detailed overview high performance ids idps along pros cons individual techniques given paper also highlights discusses requirement developing new idps detect known unknown threats
purpose intrinsically photosensitive retinal ganglion cells iprgcs mediate nonimage forming visual functions pupillary constriction circadian photoentrainment optimizing daytime nonimage forming photostimulation health benefits aimed enhance iprgc excitation using flickering instead steady light methods human subjects tested three dimensional matrix flickering stimuli three photon counts log photons three duty cycles seven flicker frequencies steady state pupil constrictions measured results among stimuli containing log photons one flickering duty cycle evoked greatest pupil constriction greater evoked equal intensity log photons continuous light frequency duty cycle also best log photons stimuli inducing constriction caused equal intensity log photons constant light log photons stimuli duty cycle flicker optimal although evoked constriction best log photons flicker conclusions pupillary constriction depends flicker frequency duty cycle besides intensity among stimuli tested one lowest photon count inducing maximal response log photons flickering duty cycle data could guide design healthier architectural lighting better phototherapy devices treating seasonal affective disorder jet lag
paper examines pattern extent energy development steppe landscapes northeast colorado united states compare landscape disturbance created oil gas production wind energy inside pawnee national grasslands eastern side high steppe landscape consists mosaic federal state private lands dominant economic activities include ranching agriculture tourism oil gas extraction wind energy generation utilizing field surveys remote sensing data geographic information systems techniques quantify map footprint energy development landscape level findings suggest oil gas wind energy development resulted relatively small amount habitat loss within study area footprint stretches across entire zone fragmenting mostly grassland habitat futhermore third feature landscape non energy transportation network also found significant impact combined three features fragment entire pawnee national grasslands eastern side leaving large intact core roadless areas primary objective ongoing work create series quantifiable replicable surface disturbance indicators linked energy production semi arid grassland environments based future results aim work industry regulators shape energy policy relates environmental performance aim reducing footprint thus increasing sustainability extractive activities
paper presents short overview today unstable environment communication implies serious actions regarding development new solutions ensures confidential communications mobile devices paper analyzes cryptography steganography performances mobile platforms used smartsteg project test performances different types operating systems devices take consideration functionality time needed process information security
traditional visual secret sharing vss scheme encodes secret binary image shares random pattern shares printed onto transparencies secret image visually revealed subset transparencies stacked together otherwise nothing revealed progressive visual secret sharing pvss also allows decryption secret image stacking physical transparencies clarity contrast decoded secret image increased progressively number stacked shares existing researches pvss suffer common problems like space inefficiency pixel expansion noise like shares paper proposes novel pvss scheme four number space efficient well meaningful shares achieve efficient preprocessing approach basis matrix creation algorithm also proposed paper also addresses many avoidable encryption limitations like explicit requirement codebook restriction number shares etc experiments show contrast reconstructed secret image easily decrypted human visual system without cryptographic computation
objectivesto determine cross sectional association cerebral amyloid beta deposition gait designcross sectional settingpopulation based cohort study olmsted county participantscognitively normal individuals aged years enrolled mayo clinic study aging concurrent pib pet imaging gait assessment participants history stroke alcoholism parkinson disease subdural hematoma traumatic brain injury normal pressure hydrocephalus excluded measurementspib pet suvr measured prefrontal orbitofrontal parietal temporal anterior cingulate posterior cingulate motor specific regions interest rois gait parameters speed cadence stride length double support time intra individual stance time variability measured using gaitrite instrumentation linear regression models adjusted age sex body mass index education apoe epsilon allele charlson comorbidity index depression secondary analyses additionally adjusted neurodegeneration hippocampal volume fdg pet suvr cortical thickness associated regions resultsin fully adjusted models including neuroimaging measures neurodegeneration higher pib pet suvr across rois associated slower gait speed except parietal roi lower cadence longer double support time except motor roi greater stance time variability sex stratified analyses association higher pib pet suvr across rois measures gait present among women conclusionpib pet suvr across rois independent general measures associated neurodegeneration associated poorer performance multiple gait parameters among cognitively normal women aged years longitudinal studies needed determine whether predicts gait decline women men
objective explored whether children adhd deficit relational reasoning skill subtending acquisition many cognitive abilities social rules method analyzed performance group children adhd transitive inference task task requiring first learn reciprocal relationship adjacent items rank ordered series second deduct relationship novel pairs items never matched learning results main result observed children adhd impaired performing inferential reasoning problems deficit relational reasoning found related difficulty managing unified representation ordered items conclusion present finding documented novel deficit adhd contributing improving understanding disorder
numerous health legislations concerning child mortality maternal health life threatening diseases polio tuberculosis crafted health sector pakistan critical assessment health legislations points effective sub optimal implementation engaging concept public law strong relationship public health health legislations basic purpose health legislations craft enforce essential health legislations improving public health examination health legislations across pakistan indicate extensive health engagement facing certain challenges indicating traditional health practices enforcement constraints arising due political compulsions complexities systematic problems health sector reflecting issue governance focus group discussions depth interviews held policy makers senior health officials private health entities parliamentarian tasks forces millennium development goals study engages health sector legislations focuses problematic health sector interventions observed unless overarching legislative framework shift programmatic approach human rights approach adopted targets millennium development goals would remain track pakistan
background interstitial lung disease ild frequent complication systemic sclerosis ssc mixed connective tissue disease mctd disease heterogeneous outcome unpredictable patients severe progressive deterioration ild leading cause mortality aimed determine whether serum levels krebs von den lungen surfactant protein correlate ssc mctd associated ild activity methods retrospectively analyzed medical records patients ssc mctd associated ild patients ssc patients mctd measurement serum levels pulmonary function tests high resolution computed tomography hrct performed parallel reviewed results serum correlated positively diffusing capacity lung carbon monoxide dlco predicted disease extent hrct changes serum levels significantly related changes forced vital capacity fvc ssc mctd associated ild hand multivariate logistic regression analyses calculation area curve receiver operating characteristic curve suggested higher serum level significant predictor fvc decline ssc mctd associated ild conclusions study suggests serum useful monitoring tool ssc mctd associated ild activity contrast serum may significant predictor potential fvc decline short term
volume variety data published semantic web constantly increasing growing number entities stakeholders expressing data form owl rdfs ontologies however large amount data still maintained relational databases recent developments sparql endpoints server constitute important step towards introduction relational databases semantic web however underlying models tightly linked data structure controlled terminologies employed hence pose serious barrier accessing data using different languages previous work presented ontology alignment tool bridging gap among terms two ontologies based instantiation one ontology patterns paper analytically describe novel approach accordingly designed system enabling users access data residing relational databases using different models vocabularies ones supported sparql endpoint approach based specification consumption correspondences particular focus sparql query rdf data rewriting mechanisms responsible making necessary changes queries optionally results retrieved sparql endpoint taking account models vocabularies used side
paper conduct research modern architecture planning design patterns green low carbon background nowadays development national green building although big progress order realize true sense green building one hand also need pay attention feature architectural design operation concept sustainable development green building long term development leave progress science technology efforts construction industry green building save resources reduce energy consumption paper combines state art theoretical ideas propose modification terms promoting current status meaningful
patients already taking blood pressure lowering therapy hospital admission acute stroke individual patient data meta analysis randomized controlled trials undertaken determine effect continuation versus temporarily stopping preexisting antihypertensive medication acute stroke key databases searched trials following inclusion criteria randomized design stroke onset hours investigating effect continuation versus stopping prestroke antihypertensive medication follow weeks two randomized controlled trials identified included meta analysis individual patient data patients hours acute stroke risk bias study low adjusted logistic regression multiple regression analyses using random effects found significant association continuation prestroke antihypertensive therapy versus stopping risk death dependency final follow odds ratio confidence interval significant associations found continuation versus stopping therapy secondary outcomes final follow analyses death dependency prespecified subgroups revealed significant associations continuation versus temporarily stopping therapy exception patients randomized hours difference favoring stopping treatment met statistical significance found significant benefit continuation antihypertensive treatment acute stroke period therefore urgency administer preexisting antihypertensive therapy first hours days stroke unless indicated comorbid conditions
increasingly strict requirements control speed system performance unavoidable time delay becomes serious problem fractional order feedback constantly adopted control engineering due advantages robustness strong noising ability better control performance paper dynamical characteristics autonomous duffing oscillator fractional order feedback coupling time delay investigated first first order approximate analytical solution obtained averaging method equivalent stiffness equivalent damping coefficients defined feedback coefficient fractional order time delay found fractional order feedback coupling time delay functions delayed velocity feedback delayed displacement feedback simultaneously comparison analytical solution numerical one verifies correctness satisfactory precision approximately analytical solution three parameter conditions respectively effects feedback coefficient fractional order nonlinear stiffness coefficient complex dynamical behaviors analyzed including locations bifurcation points stabilities periodic solutions existence ranges periodic solutions stability zero solution stability switch times found increase fractional order could make delay amplitude curves periodic solutions shift rightwards stabilities periodic solutions stability switch times zero solution changed decrease feedback coefficient makes amplitudes ranges periodic solutions become larger induces stability switch times zero solution decrease stabilities periodic solutions keep unchanged sign nonlinear stiffness coefficient determines stabilities bending directions delay amplitude curves periodic solutions bifurcation points stability zero solution stability switch times changed could concluded primary system parameters important influences dynamical behavior duffing oscillator results helpful design analyze control kind system analysis procedure conclusions could provide reference study similar fractional order dynamic systems time delays
rolandic epilepsy benign epilepsy childhood centrotemporal spikes bect frequent idiopathic partial epilepsy syndrome childhood idiopathic implies genetic predisposition although long presumed genetic component clinical genetic studies shown complex inheritance pattern furthermore underlying major genetic influence challenged recent reports twin studies meanwhile many genes loci shown associated atypical spectrum higher frequency causative variants however full understanding genetic basis common forms spectrum remains elusive british epilepsy association published elsevier ltd rights reserved
child abuse various types physical emotional sexual neglect document throughout history however mid century inflicted injuries children overlooked part children often viewed property according world health organization children victims homicide year paper present skeletal radiological manifestation physical abuse fatal neglect provide recommendations assess child maltreatment past populations pediatric biomechanical factors healing discussed important keep mind children small adults skeletal radiological indicators nonaccidental inflicted injuries reviewed literature inflicted injuries presented based specificity identify child abuse addition skeletal indicators could help assess fatal starvation also reviewed metabolic diseases proposed potential evidence neglect recent child homicide presented used illustrate difficulty assessing child maltreatment present day clinical child abuse protocols used provide recommendations assess child abuse bioarchaeological context clin anat wiley periodicals inc
abusive head trauma aht suspected child dilated eye examination ophthalmologist essential part medical workup presence pattern retinal hemorrhages high positive predictive rate abusive head injury article proposes review clinical presentation pathophysiology natural history sequelae differential diagnosis retinal hemorrhages ocular lesions associated aht
objective functional gastrointestinal disorders affect females often changes colonic motility may etiological factors clinical symptoms aim present study analyze influence gonadal hormones colonic contractile activity methods vitro measurements colonic contractile activity longitudinal smooth muscle strips female male lewis rats performed organ chamber experiment administration gonadal hormone estradiol est progesterone prog testosterone test ethanol solution control stimulation acetylcholine ach inhibition norepinephrine performed results compared smooth muscle strips male rats significantly higher spontaneous colonic contractile activity scca observed female animals increasing doses ach showed progressive stimulation scca whereas rising doses resulted stepwise inhibition scca respectively est superfusion displayed inhibitory effect scca sexes inhibited ach effect female rats similarly acute superfusion high dose prog inhibited scca females acute test superfusion inhibited scca males led significant higher colonic contractile activity males following subsequent stimulation ach female rats inhibitory effect reduced prior exposure test conclusion vitro study acute exposure colonic smooth muscle tissue gonadal hormones led sex dependent changes scca translated modified response smooth muscle strips pro contractile anti contractile neurotransmitters
backgroundautomated peripheral blood image analyzers usually underestimate total number blast cells mixing reactive normal lymphocytes therefore able discriminate myeloid lymphoid blast cell lineages objective proposed work achieve automatic discrimination reactive lymphoid cells rlc lymphoid myeloid blast cells obtain morphologic patterns feature analysis methodsin training stage set blood cell images selected patients myeloid acute leukemia lymphoid precursor neoplasms viral infections classification used support vector machines testing different combinations feature categories feature selection techniques validation implemented using selected features images new patients five corresponding category resultsbest discrimination accuracy training obtained feature selection whole feature set selected features showing significant differences mean values different cell groups nucleus cytoplasm ratio important feature cell classification color texture features cytoplasm also important validation stage overall classification accuracy true positive rates rlc myeloid lymphoid blast cells respectively conclusionthe methodology appears able recognize reactive lymphocytes well especially reactive lymphocytes lymphoblasts
web linked data growing rapidly due potential facilitate data retrieval data integration time relational database systems store vast amount data published web current linked data web mainly read allows integration navigation consultations large structured datasets still lacks general concept reading writing paper proposes specification entitled semantic data services sds restful web services provide data access provide linked data read write capacity sds proposes mechanism integrity checking analogous used relational databases sds implements semantic restful interface serin specification serin uses annotations classes ontology describing semantic web services available manipulate data work extends serin specification adding annotations allow adoption data access integrity constraints
polymeric heart valves phv engineered serve alternatives existing prosthetic valves due higher durability hemodynamics similar bioprosthetic valves purpose study evaluate effect geometry phvs coaptation hemodynamic performance two geometric factors considered stent profile leaflet arch length varied across six valve configurations three models created height diameter ratio three models designed altering arch height stent diameter ratio particle image velocimetry experiments conducted phv characterize velocity vorticity turbulent characteristics effective orifice area regurgitant fraction study revealed presence arches well higher stent profile reduced regurgitant flow peak systole downstream velocity reduced reynolds shear stress values reduced earlier reattachment forward flow jet observed phvs leaflet arches findings indicate although geometric factors help diminish commissural gap diastole leaflet arches induce larger jet opening yielding earlier flow reattachment lower energy dissipation
context climate change effect poverty previous studies shown productivity shocks agriculture rainfall variability affect wages adversely none studies however consider heterogeneity impact shocks agricultural wages gender feature studied demand shocks urban labor markets developed countries using national sample survey data india district level panel dataset created examine rainfall shock affects gender wage gap study shows female male wages positively related rainfall shocks hence future studies must study impact labor market shocks rural areas female male wages separately also finds female male wage ratio significantly positively associated rainfall shock regions rainfed rice cultivated low high rainfall reduces increases female male ratio study demonstrates result due positive association demand female labor rainfall rainfed rice growing regions finding consistent greater marginal value female labor rice cultivation also crop highly sensitive rainfall variability rainfed conditions paper concludes effect rainfall shock gender wage gap depends upon gender roles underlying technology production varies across cropping systems elsevier ltd rights reserved
cognitive radio emerging technique improve efficiency spectrum resource utilization networks selfish behavior secondary users sus considerably affect performance primary users pus accordingly game theory considers game players selfish behavior applied design networks existing studies focus network design network perspective improve system performance utility throughput however users experience service simply reflected quality service largely ignored user perceived multimedia quality service different actual received multimedia quality thus important consider network design better serve network users quality experience qoe adopted measure network service users perspective help improve users satisfaction network service networks require lot data storage computation spectrum sensing spectrum sharing algorithm design cloud computation comes convenient solution provide massive storage fast computation paper propose design user oriented cloud network multimedia applications user satisfaction reflected cloud network design proposed framework game formulated stackelberg game particular refunding term defined users utility function effectively consider reflect network users qoe requirement contributions twofold game based cloud network design multimedia transmission proposed network user qoe requirement satisfied design existence uniqueness stackelberg nash equilibrium proved design optimal simulation results demonstrate effectiveness game user oriented cloud network design
prostate cancer cells typically show increased expression prostate specific membrane antigen psma visualized psma pet aim study assess intensity psma uptake primary tumour metastases patients biopsy proven prior therapy determine whether correlation exists primary tumour related psma accumulation gleason score prostate specific antigen psa level ninety patients transrectal ultrasound biopsy proven median psa referred psma pet retrospectively analysed pet images analysed visually semiquantitatively measuring maximum standardized uptake value suvmax suvmax primary tumour pathologic lesions suspicious lymphatic distant metastases compared physiologic background activity normal prostate tissue gluteal muscle suvmax primary tumour assessed relation psa level eighty two patients demonstrated pathologic tracer accumulation primary tumour exceeded physiologic tracer uptake normal prostate tissue median suvmax tumours showed significantly lower psma uptake median suvmax respectively compared patients median suvmax exhibited significantly higher uptake psa levels median suvmax versus
sampangine azaoxoaporphine alkaloid interesting biological activities elucidating mode action sampangine topic continuous research recently reported cell based data indicated heme dysfunction subsequent reactive oxygen species production responsible biological activity natural product using vitro biochemical assay ability sampangine produce reactive oxygen species confirmed production reactive oxygen species occurred upon mild chemical reduction sampangine absence cellular components additional structure activity relationship study utilizing synthesized analogs sampangine identified iminoquinone scaffold key motif observed reactive oxygen species production assess ability sampangine induce dna damage direct binding sampangine calf thymus dna measured using visible spectroscopy dna binding observed sampangine tested calf thymus dna ratio observation rules direct involvement sampangine dna binding damage
backgroundopioid induced depression sex hormones common finding chronic pain patients receiving long term opioids oral parenteral even intrathecal routes administration hypothalamic suppression opioids leads hypogonadal state low testosterone levels males subsequent low bone mineral density bmd methodswe studied effects intrathecally administered opioids bmd group male chronic pain patients addition studied effects supplementary testosterone bone metabolism see adverse effects intrathecal opioids reversed resultseleven patients supplementary testosterone previously diagnosed hypogonadal low serum testosterone duration testosterone supplementation greater years patients serum total free testosterone levels higher patients supplementary testosterone patients receive treatment patients testosterone supplement low serum testosterone levels nmol low osteoporotic scores within group low free testosterone associated low bmd scores persisted correcting age eight patients testosterone supplement normal bmdt scores three low osteoporotic scores age corrected bmdz scores significantly greater patients testosterone supplements bmd scores patients conclusiontestosterone supplementation found largely correct effects intrathecal opioids testosterone levels bmd
paper deals research advanced hierarchical graph structures developed knowledge representation computer aided design robotics complex real life engineering problems still need useful graph based models new approach represent models preserving intrinsic nature problem structures using graphs many hierarchies proposed different types hierarchical dependencies geometrical functional etc design parts expressed one structure moreover possibility selecting problem related hierarchies reduces number data analysed process reasoning considered designs approach illustrated applying multi hierarchical graph structures represent complex data used robot control algorithms elsevier rights reserved
two dimensional incompressible boussinesq equations model geophysical fluids play important role study raleigh bernard convection mathematically system retains key features navier stokes euler equations vortex stretching mechanism issue whether boussinesq equations always possess global time classical solutions difficult partial dissipation dissipation paper obtains global regularity two partial dissipation cases proves several global priori bounds two prominent partial dissipation cases results take one step closer complete resolution global regularity issue partial dissipation cases involving boussinesq equations elsevier inc rights reserved
paper tip tracking control problem timoshenko micro cantilever beam investigated beam actuated piezoelectric layer laminated one side beam dynamic equations beam piezoelectric layer found using hamilton principle employing galerkin projection method state space representation system derived cascade control loop used tracking control beam tip cascade control structure consists inner loop stabilizer outer loop proportional integral derivative controller stabilizer linear feedback form whose states obtained linear observer based beam tip displacement measurement stability analysis inner loop stabilizer performed study effects higher controlled modes performance controlled system simulation results show effectiveness proposed control method
background selenium essential trace element humans animals needed broad variety physiological functions including thyroid hormone metabolism protection oxidative stress immunity associated functions human nutritional deficiencies associated neuropsychiatric diseases like alzheimer disease parkinson disease obsessive compulsive disorder stroke epilepsy well depressive behaviours study examined antidepressant anxiolytic like activity inorganic form sodium selenite investigated whether influence locomotor activity mice methods antidepressant like anxiolytic like activity assessed using forced swim test fst elevated plus maze test epm respectively spontaneous locomotor activity measured using photoresistor actimeters results sodium selenite administered doses reduced immobility time fst exerting antidepressant like activity epm test sodium selenite doses produced anxiolytic like effect doses active tests affect locomotor activity indicating effects specific conclusions potential antidepressant anxiolytic like effects require detailed experimental study using animal models approach clear conclusion regarding potential mechanism observed effect published elsevier behalf institute pharmacology polish academy sciences
paper presents result teaching methodology first year engineering subject materials processes improve overall grade associated pass rate students borderline university entrance shown great difficulty first year engineering degree program smoothing school graduates first year transition period second year first intensive engineering form study university system teaching learning strategies common first year subject materials processes implemented past years improve grades student pass rate approach taken many universities accept students lower entrance scores fill quotas engineering increasing employment prospects pick first year subject student academic results increased overall grade cohort pass rate results series student surveys indicate significant positive student feedback teaching learning approach resulted grade improvement results encouraged continuation similar approaches first year subjects
introduction well established childhood maltreatment detrimental impact brain particularly hippocampus however hippocampus functionally structurally heterogeneous region little known maltreatment might affect hippocampal subregion development throughout important periods plasticity study investigated whether childhood maltreatment associated development hippocampal subregion volumes early late adolescence also investigated associations onset psychiatric disorder hippocampal subregion volume development methods one hundred sixty six male adolescents took part three magnetic resonance imaging assessments adolescence mean age assessment years years years provided self report childhood maltreatment assessed axis psychopathology results childhood maltreatment associated development right total left cornu ammonis volumes early late adolescence early late onset psychopathology associated development right presubiculum right cornu ammonis volumes respectively maltreatment findings appeared specific males whereas psychopathology findings appeared specific females conclusions findings provide evidence possible deleterious effects childhood maltreatment early onset psychiatric disorder development different subregions hippocampus altered development right hand might precede development late adolescent onset psychopathology results highlight importance considering development research examining associations stress mental illness hippocampal morphology
background childhood cancer survivors risk recurrence primary cancer well secondary site cancers survivors also increased risk long term effects chronic illnesses health promoting lifestyles therefore especially important childhood cancer survivors purpose study describe health promoting behaviors childhood cancer survivors determine whether behaviors associated demographic clinical characteristics descriptive comparative study took place oncology follow clinic israel sample seventy seven childhood cancer survivors tools health promoting lifestyle profile questionnaire interpersonal relationships spiritual growth physical activity nutrition health responsibility stress management smoking alcohol consumption demographic clinical questionnaire mean item score moderate high survivors scored highest interpersonal relationships spiritual growth lowest scoring activities physical activity nutrition survivors abstained smoking alcohol consumption women opposed men likely higher scores related nutrition interpersonal relationships singles opposed married found higher scores related spiritual growth conclusions health behaviors associated interpersonal relationships spiritual growth likely performed compared physical activity good nutrition decreased smoking alcohol consumption special attention placed promoting physical activity good nutrition among survivors childhood cancer
background primary objective study characterize changes cerebral blood flow measured using transcranial doppler children central nervous system infections hypothesized children central nervous system infections abnormal cerebral blood flow associated greater frequency complications poor neurological outcome methods conducted single center retrospective study children admitted neonatal pediatric intensive care unit central nervous system infection undergoing transcranial doppler part routine care march july results total children central nervous system infection underwent transcranial dopplers mean age years including boys eight girls common infection meningitis remainder comprising encephalitis meningoencephalitis abscess empyema bacterial viral sources common one fungal infection three unknown presumed viral etiology patients underwent transcranial doppler days intensive care unit admission mean cerebral blood flow velocities overall increased compared reference values age healthy children critically ill children mostly hyperemia vasospasm hypoperfusion cerebral blood flow velocity normal value least one vessel associated morbidity intubation vasoactive medications neurosurgery cardiac arrest mortality two patients increased intracranial pressure hyperventilation safely achieved transcranial doppler monitoring avoid ischemia serial transcranial dopplers used guide blood pressure management conclusions transcranial doppler used children central nervous system infection tool assess cerebral blood flow retrospective study cerebral hypoperfusion associated increased morbidity mortality transcranial doppler guide medical therapy management cerebral blood flow children central nervous system infections results need validated prospective studies homogenous population children encephalitis meningitis
network security becoming important lot anomaly traffic information websites online education order detect anomaly traffic effectively use cloud computing tools hadoop sake good performance hadoop need performance tuning paper mainly focused two aspects performance tuning paper deeply researched phases hadoop like map reduce effective hadoop greatly improved help performance tuning paper pointed compressed trie algorithm replace hash table map phase solved problem low efficiency
since birth european higher education area ehea higher education institutions european countries involved complex process designing curricula according new educational criteria oriented convergence contents methodologies teaching university curricula according principles pursued named bologna process present work focused description experiences accumulated authors adaptation courses manufacturing engineering previous stage complete formulation study plans engineering programmes taught escuela tecnica superior ingenieria industrial etsii universidad politecnica cartagena strategies followed enhancement interest students towards theoretical practical teachings promotion traverse specific competences specially associated courses explained work well academic results provided new educational methodologies assumed teaching learning process
article presents new method optimally partition geometric domain capacity constraints partitioned regions important problem many fields ranging engineering economics known capacity constrained partition obtained power diagram squared metric present method super linear convergence computing optimal partition capacity constraints outperforms state art order magnitude demonstrate efficiency method context three different applications computer graphics geometric processing displacement interpolation function distribution blue noise point sampling optimal convex decomposition domains furthermore proposed method extended capacity constrained optimal partition respect general cost functions beyond squared euclidean distance
horsley gantt joseph brady laid rich foundation understanding concept emotion derived prominent traditions physiology psychology classic conditioning operant conditioning respectively framework guided fierce interest motivation general interaction reward stress began john hopkins thesis work guidance drs zoltan annau solomon synder joseph brady among many others using study neurobiology addiction framework argue drug addiction involves positive reinforcement associated rewarding effects drugs abuse also involves another major source reinforcement specifically negative reinforcement driven negative emotional states termed dark side addiction excessive activation brain reward systems leads antireward decrease function normal reward related neurocircuitry persistent recruitment brain stress systems may neurobiologically linked understanding neuroplasticity neurocircuitry comprises negative reinforcement associated addiction key understanding negative emotional states general pathophysiology
fluid flow micro nanofluidics utmost importance analyzing mechanical biological medical systems biological liquids often electrolytes produce spontaneous electrokinetic effects flowing pores channels streaming potential resultant electrokinetic phenomenon drives ions channel move direction opposite pressure driven flow causes resistance fluid flow along channel simply similar case viscosity fluid slightly increased expected lower flow rate presence electroviscous effects however understanding effects thermal transport characteristics would interesting present study attempts present theoretical investigation electroviscous effects heat transfer nanofluidics based continuum fluid mechanics boundary slip assumed walls results show presence electroviscous effects remarkably enhance heat transfer rate elsevier ltd rights reserved
fully take advantage external charging conditions reduce fuel consumption extended range electric vehicles charging management based intelligent control strategy proposed intelligent control strategy applied different driving patterns based various characteristics urban roads vehicle driving arterial roads constant power control strategy applied driver decides charging station extender time determined based current state vehicle distance charging station vehicle driving expressway power follower control strategy applied range extender engine controlled work wide variety regions obtain optimum fuel economy simulation results indicate vehicle arrives charging station proposed charging management based intelligent control strategy made state charge reach lowest permissible level driver made decision charge charging station therefore driver charge vehicle much clean electric energy possible charging station
paper velocity tracking controller hydrostatic drive transmissions developed solution based state dependent model incorporates nonlinear characteristics system full state feedback controller devised gains scheduled measured speed pressures together approximated volumetric flow effects uncertainties especially related equilibrium values pressures eliminated utilizing called implementation technique eliminates need equilibrium values model based thus uncertain demonstrate efficacy controller solution implemented ton wheel loader comparison purposes constant gain state feedback controller integral action devised also linear pid controller tuned results show benefits devised controller significant compared two controllers moreover controllability machine maintained every situation
background although patient preference core value within context patient centered models care little attention paid determining patient preference instructional media nurses traditionally used verbal face face instruction mainstay patient education written materials used extensively teaching guides supplement verbal instruction instructional reinforcement however advances technology made possible adding video instruction nurses repertoire instructional media objectives purpose study determine patients media preferences verbal video written receiving instructional reinforcement self care needed prevent radiation dermatitis methods current study conducted secondary analysis data process improvement initiative parent study patients received multimedia education related skin care prevent radiation dermatitis secondary analysis examined patient preference verbal video written education reinforcement treatment weeks findings results suggest given choice verbal video reinforcement preferred written reinforcement
aircraft electrical energy storage systems eess used support sources mission phases order ensure energy availability also used electrical smoothing devices order guarantee required levels reliability stability quality embedded electrical network paper deals association two eess supercapacitors secondary battery exhibit complementary properties paper sizing method eess developed taking account hybridization characteristics capacity depth discharge minimize global storage system weight moreover energy management based frequency approach implemented dispatch power sources influence management sizing studied indeed cut frequency low pass filter used setting parameter sizing algorithm finally sizing validity assessed discussed according temperature constraints although battery performances reduced low temperature sizing determined algorithm degrees still valid temperature range thanks adaptation energy management parameter elsevier rights reserved
work describes development environmental friendly functionalized polypropylene nonwoven geotextile order trap heavy metals sediments sludges chitosan chosen sorbent ability trap heavy metals natural origin shells low cost first functionalized acrylic acid using cold plasma process order bring reactive carboxylic functions onto surface chitosan covalently grafted acrylic acid modified polypropylene functionalized surfaces characterized ftir fourier transform infrared chitosan thus proven grafted ability functionalized textile trap heavy metals investigated copper chosen model heavy metal artificial solutions cuso prepared experiments sorption studies among concentration copper polluted solutions degrees carried chitosan polypropylene grafted acrylic acid chitosan order evaluate maximum absorption surface textile chelate copper increasingly initial copper concentration ppm reaches plateau effects ionic strength absorption nacl containing solution finally investigated trapping decreases slowly ionic strength increases seawater like nacl concentration textile still chelates finally optimum trap maximum amount copper determined corresponds optimum solubility chitosan
paper illustrates development prototype stage electromechanical actuation system medium voltage vacuum contactor development carried using multi domain simulation based mechatronic approach developing coordinated sub models mechanism linking actuator movable parts interrupter rotational electromagnetic actuator power control electronic circuit supplying actuator governing system via digital control unit preliminary analysis modeling design check parts via coordinated simulations presented prototype system manufactured validate design procedure finally presented
background mass gatherings present enormous challenges emergency preparedness planners must anticipate prepare communicable non communicable disease outbreaks illnesses injuries participants crowd control disaster responses unforeseen natural man made threats hajj largest annually recurring mass gathering event earth attracts million pilgrims countries assemble mecca week period methods literature review conducted using medline ovid searching published data concerning human stampedes crowd control measures implemented prevent human stampedes review extended include media reports published numbers reports hajj saudi arabian government english arabic languages results millions pilgrims undertake religious ritual within strict constraints term space time rigour strictness led series large crowd disasters several years thus putting pressure authorities past years government saudi arabia put enormous effort solve difficulty using state art innovative scientific means use crowd simulation models assessment best ways grouping scheduling pilgrims crowd management control engineering technologies luggage management video monitoring changes construction transport system event conclusions large gathering hajj still holds increasing risk future disasters international collaboration continued vigilance planning efforts remains integral part annual preparations development educational campaigns pilgrims regarding possible dangers also crucial lessons gleaned experiences hajj may influence planning mass gatherings kind worldwide elsevier ltd rights reserved
problem synchronous fractional sample rate conversion fsrc digital signal coprime integers revisited based novel approach two different efficient causal block implementations fsrc concurrently derived compared computational load structures performed lti mimo subsystem subnyquist rate identical group delay always different column row shifts matrix representation mimo subsystem possible transform structure arbitrary implementation changed group delay moreover shown structural manipulation signal flow graph mimo subsystem implementations ultimately require amount computation storage spite different group delay finally using nyquist filters maximum number input samples fsrc retained output elsevier science rights reserved
paper presents gray box equivalent circuit model ecm order predict performance direct methanol fuel cell dmfc unit ecm composed electronic components ranging operational amplifier resistors diodes current voltage profiles current power profiles ecm validated simulation results comsol model afterward influences methanol concentration operating temperature oxygen concentration performance single passive dmfc validated experimentally validations show ecm provides good approximation behavior dmfc addition simulated application circuit system employing ecm explained simulated result validated experimentally research makes possible analyze behavior dmfc real applications
procrastination refers delay postponement task decision often conceptualised failure self regulation recent research suggested procrastination could delineated two domains intentional unintentional two study paper aimed develop measure unintentional procrastination named unintentional procrastination scale ups test whether would stronger marker psychopathology intentional general procrastination study community sample participants completed questionnaire consisted several items pertaining unintentional procrastination derived theory previous research clinical experience responses subjected principle components analysis assessment internal consistency study community sample participants completed newly developed scale along measures general intentional procrastination metacognitions procrastination negative affect data ups subjected confirmatory factor analysis revised accordingly ups validated using correlation regression analyses six item ups possesses construct divergent validity good internal consistency ups appears stronger marker psychopathology pre existing measures procrastination used study results regression models suggest negative affect metacognitions procrastination differentiate general intentional unintentional procrastination ups brief good psychometric properties strong associations negative affect suggesting value research clinical tool
polymorphisms human circadian genes potential genetic markers affect diurnal preference several populations study evaluated whether four polymorphisms circadian genes clock arntl per gnb associated diurnal preference korean population healthy subjects genotyped four functional polymorphisms clock arntl per gnb composite scale morningness csm applied measure phenotype patterns human diurnal preference addition three subscale scores morningness activity planning morning alertness extracted csm significant associations observed csm scores clock genotype allele carrier status csm scores arntl allele carrier status csm scores gnb genotype allele carrier status however total csm scores scores subscales significantly associated per genotype total morningness activity planning respectively allele carrier status total morningness activity planning respectively best model result obtained performing multifactor dimensionality reduction analysis chi indicated interaction among single nucleotide polymorphism snp arntl snp gnb snp per synergistically affected risk associated diurnal preference toward eveningness results suggest circadian gene per associated diurnal preference healthy korean population although polymorphisms arntl gnb significantly associated diurnal preference interactions polymorphism per may synergistically increase risk diurnal preference toward eveningness
recent years green building booming important component environmentally friendly building composite wall insulation system attracted lot attentions paper widely used extended finite element method xfem adopted analyze heat conduction problem composite wall numerical study practical case demonstrates validity xfem thermal diffusion heterogeneous walls
recent years natural ventilation technology extensively used order improve indoor environment quality reduce power consumption air conditioning systems green buildings however effect natural ventilation fires needs evaluated carefully make energy saving buildings safe topic worth studying study uses fire dynamics simulator fire safety enhancement measures existing green building without installation smoke exhaust system since building located school campus require smoke exhaust system according taiwan fire regulations referential results obtained series improvement strategies tested show kiln natural ventilation generate comfortable air flow unfortunately due stack effect hot air fatal smoke blown evacuation route area behind room fire occurs findings showed two feasible improvement measures controlling state air inlet setting exhaust port rear room effectively resolve fire safety issues construction undertaken reasonable cost
nih sponsored patient reported outcomes measurement information system promis gastrointestinal symptoms scales developed assess patients symptoms clinical settings assess responsiveness change provide minimally important difference mid estimates promis symptoms scales sample outpatients self administered eight promis symptoms scales gastroesophageal reflux disrupted swallowing diarrhea bowel incontinence soilage nausea vomiting constipation belly pain gas bloating flatulence two visits patient self reported physician reported assessments subjects overall condition employed change anchors addition prospectively assessed change visits using symptom anchor gastrointestinal symptom rating scale gsrs responsiveness change assessed using statistics minimally changed group somewhat better somewhat worse retrospective anchors changing one category modified gsrs slight mild discomfort moderate moderately severe discomfort responsiveness change statistically significant promis scales using self report anchor scales using physician reported anchor scales using corresponding gsrs scales anchors mid estimates scales improvement worsening using gsrs anchor generally larger magnitude change group responsiveness mid estimates provided promis symptoms scales aid scale score interpretation clinical trials observational studies
singularity traditional spherical polar coordinate system poles major factor lack scalability atmospheric models massively parallel machines overset grids yin yang grid introduced kageyama sato offer potential solution problem paper three dimensional compressible non hydrostatic atmospheric model developed tested yin yang grid building ideas previously developed authors solution elliptic boundary value problems conservation overset grids using several tests literature shown model highly stable even little centering accurate highly efficient terms computational cost model also incorporates highly efficient accurate approaches achieve positivity monotonicity conservative transport paramount requirements atmospheric model parallel scalability model using excess million unknowns processors also discussed shown compare favourably highly optimised latitude longitude model terms scalability actual run times crown copyright published elsevier inc rights reserved
backgroundsuicide become serious worldwide mental health problem including asian countries suicidal ideation happens prior actual suicidal behaviour thus identifying roots suicidal ideation vital study investigated relationships parental closeness self efficacy suicidal ideation among adolescents malaysia mediation effect self efficacy relationship parental closeness suicidal ideation also examined methoda total school going adolescents aged years old recruited via multistage cluster sampling bivariate analysis conducted using pearson correlation analysis mediation model tested using spss macro developed preacher hayes resultsthe results showed mother closeness father closeness self efficacy significant negative correlation suicidal ideation specifically self efficacy emerged partial mediator relation mother closeness suicidal ideation self efficacy also fully mediated relationship father closeness suicidal ideation conclusionsthe findings implied mother closeness stronger correlation adolescents suicidal ideation compared father closeness self efficacy plays important role relationship parental closeness suicidal ideation prevention intervention efforts practitioners dealing adolescents mental health issues specifically suicidal ideation seriously consider providing skills enhance mother adolescent relationship self efficacy
background smart home technologies comprising environmental sensors wearables video attracting interest home healthcare delivery development technology usually justified basis technology potential increase autonomy people living long term conditions studies ethics smart homes raise concerns privacy consent social isolation equity access studies investigated ethical perspectives smart home engineers exploring views engineering researchers large smart home project sought contribute dialogue ethics engineering community methods either face face using skype conducted depth qualitative interviews early midcareer smart home researchers multi centre smart home project asked describe experience reflect broadly ethical considerations relate smart home design participants consent interviews audio recorded transcribed analysed using thematic approach results two overarching themes emerged privacy researchers indicated paid close attention negative consequences potential unauthorised information sharing current work however discussing broader issues smart home design beyond confines immediate project researchers considered physical privacy lesser extent even though physical privacy may manifest emotive concerns watched monitored choice researchers indicated often saw provision choice end users solution ethical dilemmas researchers indicated choices end users may need restricted technological reasons ethical standpoints restrict choice usually assumed embedded design conclusions tractability informational privacy may explain greater attention paid however concerns physical privacy may reduce acceptability smart home technologies future end users attention choice suggests links privacy may misidentify sources privacy risk unjustly burdening end users problems resolve separating considerations choice privacy may result satisfactory treatment finally engagement researchers participants study demonstrates relevance bio ethics critical partner smart home engineering
common mode differential mode impedances crucial emc networks modeling filter design particular paper propose original analytical model common mode differential mode input impedances converter including major parasitical elements model synthesized using basic laws electrical circuits analysis converter circuit achieved switching function modeling nonlinear behavior assess model performance pspice online simulations common mode differential mode input impedances achieved devices operating results obtained agree analytical model wide emc regulation frequency range cispr furthermore carried online experimental test bench means capacitive injection technique results obtained confirm validity analytical model highlight impedance switching effect offline measurement also conducted using impedance analyzer agilent
article examines nature shifting gender roles liberia postconflict reconstruction process specifically investigates ways political authority gendered agency women politics employ justify participation attempt reduce gender inequalities institutional level argue intervention international community instrumental providing space resources gender mainstreaming however absence depth intersectional analyses gender dynamics unintended consequences peacebuilding policies could hinder sustainability long term peace article based qualitative research country study conducted author rural urban liberia following election ellen johnson sirleaf discussion key findings exemplified excerpts key informant interviews focus group discussions seek give voice cross section liberians contribute ongoing debate gender mainstreaming postconflict societies bridge gap local international discourses
objectivesomatic mutations asxl seem negative prognostic impact patients several myeloid neoplasms including myelofibrosis aim work determine prevalence profile asxl mutations methodswe analyzed mutations asxl consecutive patients spanish hospitals means sanger sequencing well jak calr mpl mutations resultsasxl mutations found cases commonly glytrpfsx mutations frameshift mutations asxl wild type patients least one single nucleotide polymorphism snp triple snp tsnp patients overall survival probability tsnp patients asxl patients conclusionasxl mutations found cases glytrpfsx frequent mutations found individual cases previously reported pattern also seen series fifty percent asxl patients combination three specific snps might prognostic correlation needs determined larger series
elaborated intrusion theory desire proposes craving two stage process whereby initial intrusions desired target subsequently elaborated mental imagery present study tested whether craving reduction strategies cognitive defusion guided imagery could differentially target intrusion elaboration stages respectively thus differentially impact craving process participants randomly assigned cognitive defusion guided imagery mind wandering control condition pre post intervention chocolate related thoughts intrusiveness thoughts vividness imagery craving intensity chocolate consumption compared experiment recruited general sample young women whereas experiment recruited sample chocolate cravers wanted reduce chocolate consumption across experiments cognitive defusion lowered intrusiveness thoughts vividness imagery craving intensity guided imagery reduced chocolate related thoughts intrusiveness vividness craving intensity chocolate cravers experiment general sample experiment group differences chocolate consumption either experiment results add existing evidence supporting elaborated intrusion theory desire food domain suggest acceptance imagery based techniques potential use combatting problematic cravings elsevier ltd rights reserved
background male involvement antenatal care promoted important intervention increase positive maternal new born health outcomes despite active promotion stimulate male involvement antenatal care men tanzania accompany women antenatal care visits study aims understand perceptions attitudes behaviour men regarding role involvement pregnancy antenatal care visits rural district tanzania methods data collection took place magu district september march using mixed method approach included observations six government health facilities nine focus group discussions total participants semi structured interviews participants included convenience snowball sampling additionally questionnaire distributed among women attending antenatal care regarding partners involvement pregnancy qualitative analysis done coding themes based three delays framework descriptive analysis used quantitative data results male involvement pregnancy antenatal care magu district low although men perceived antenatal care important pregnant women husbands passive attitude concerning involvement barriers male involvement included traditional gender roles lack knowledge perceived low accessibility join antenatal care visits previous negative experiences health facilities conclusion although several barriers impede male involvement antenatal care men internal motivation attitudes towards role pregnancy generally positive increasing community awareness knowledge importance male involvement increasing accessibility antenatal clinics reduce barriers
hybrid photoelectrochemical microbial fuel cell hpmfc constructed simultaneous utilization solar energy bioenergy installing tio photoanode next bioanode shares cathode microbial fuel cell mfc connecting photoelectrochemical pec circuit results enhanced cathode potentials mfc based differences power output characteristics mfc pec alone improved power production mfc accompanied relatively small decline power density pec yielding overall enhancement power output hpmfc
background negative body image risk factor development relapse eating disorders many patients continue dissatisfied body shape weight treatment study presents qualitative analysis written reflections body image patients negative body image acceptance commitment therapy group treatment specialized unit method treatment participants answered questionnaire open ended questions thoughts body image data analyzed conventional content analysis results body image meant different things different participants evaluate body whereas others focused whether body image realistic emphasized relationship body described body image strongly related global self esteem different views concept body image affected participants descriptions body image wanted change body image considered state fluctuated day day treatment participants described changes body image instance perceiving oneself less judgmental towards one body shift focus important things life conclusions participants different views body image wished change thus treatment interventions targeting negative body image needs address various aspects complex construct
purpose study evaluate possibility early detection pulmonary fungal infections lung scan chronic granulomatous disease cgd retrospective study patients affected cgd total infectious episodes performed revision clinical data scan analysis treatment performed presence lung nodules evaluated infectious episodes patients total nodules scans identified identification infectious agent biopsy vitro culture resulted positive cases remaining cases received clinical radiologic diagnosis suspected pulmonary fungal infection cases introduction empirical antifungal treatment resulted reduction size complete resolution pulmonary lung nodules patients affected cgd lung scan allows early detection pulmonary fungal infection cgd pulmonary nodules single multiple uni bilateral without halo sign may represent first radiologic sign pulmonary fungal infection cgd
soil steaming preventive non chemical weed control method designed studied new prototype band steaming machine tests conducted growing cycle organically cultivated carrot real field conditions order study effect different steam doses crops natural weed seedbank throughout whole growth cycle prototype steam generator applies steam soil bands wide steam mixed soil mean apposite rotary cultivator four biological steam doses applied combination cao prior sowing crop log logistic models used describe responses temperatures weed density time required hand weeding weed dry biomass harvest carrot yield band steaming application based experimental data economic margin evaluated find optimum application dose overall responses influenced steam dose results showed maximum temperature degrees depth observed steam dose dose operative time approximately total fuel consumption estimated mean steam dose could able provide similar yield hand weeding times responses highest steam dose applied thus reducing operative time fuel consumption machine iagre published elsevier ltd rights reserved
historical environmental cultural contexts intersect aging sexuality gender across communities generations scholarship investigates health well life course across marginalized communities including lgbtq lesbian gay bisexual transgender queer midlife older adults native communities experiencing cardiovascular risk families china living hiv order balance realities unique lives contemporary society probing intersection age sexuality gender analysis informed personal professional experiences death partner occurring time profound invisibility silence hiv aids found life sync experiencing loss without name life thrust paradox relationship defined world refused recognize essay provides opportunity weave together critical turning points life helped shape approach gerontology gerontology informed work life reflecting journey illustrate ways historical structural environmental psychosocial biological factors affect equity health promoting adverse pathways health well across marginalized communities although gerontology discipline historically silenced lives marginalized older adults much learn communities growing increasingly diverse older adult population provides unique opportunities better understand cultural variations shared experiences aging life course
background patients borderline personality disorder bpd experience auditory verbal hallucinations avh however impact hallucinations suicidal ideation suicide attempts crisis service interventions hospital admissions unknown methods cross sectional design data collected psychotic symptom rating scales psyrats mini international neuropsychiatric interview plus well medical records convenience sample outpatients fulfilling dsm criteria bpd results included patients experienced avh latter group presence avh associated significantly higher incidence suicidal plans attempts month prior study participation hospitalisations shorter interval hospitalisation subscales psyrats correlated positively suicide plans phenomenological emotional subscales also correlated positively suicide attempts moreover higher scores emotional subscale associated hospital admissions conclusions avh experienced patients bpd might constitute risk factor suicide plans attempts hospitalisation finding emphasises population requires adequate clinical attention well effective treatment avh elsevier masson sas rights reserved
confounded signal hypothesis maintains facial expressions anger happiness order efficiently communicate threat nurturance evolved forms take advantage older gender recognition systems already attuned similar affordances two unexplored consequences hypothesis facial gender automatically interfere discriminations anger happiness controlled attentional processes like working memory may able override interference particular expressions gender discrimination issues explored administering garner interference task along working memory task index controlled attention results show good attentional control able eliminate interference expression gender decisions interference gender expression decisions trials stimulus attributes systematically correlated also revealed strategic facilitation participants high attentional control
next generation internet also known internet things iot ubiquitously integrate trillions computing devices kinds shapes sizes ubiquity materialize key aspect certainly interoperability capability different technologies different communication protocols horizontal vertical levels different hardware platforms different operating systems fixed mobile nodes etc talk understand major enabler interoperability use standard commercial shelf technologies communication protocols hardware platforms operating systems ipv become facto communication technology internet lowpan recently started paving way extending internet low power low cost wireless devices however mobility support requirement least beneficial many applications contexts support mobile nodes default lowpan rpl protocol leads excessive packet loss delays work show interoperability fixed mobile nodes successfully achieved use appropriate hand topology management techniques propose mobility management framework dubbed mrpl unifying two hand models hard hand mobile node break link finding new link soft hand mobile node selects new link disconnecting current one importantly mrpl integrated lowpan rpl stack backward compatible manner simulation results indicate network mobile nodes packet delivery ratio mrpl nearly rpl achieves best case hand process disconnected period milliseconds hand delay rpl experiences seconds disconnection node mobility elsevier rights reserved
carbonaceous stationary phases gained much attention peculiar selectivity robustness herein report fabrication application graphene coated polymeric stationary phase anion exchange chromatography graphene coated particles fabricated facile evaporation reduction method hydrophilic particles proven appropriate substrates grafting hyperbranched condensation polymers hbcps make pellicular anion exchangers new phase characterized zeta potentials fourier transform infrared spectroscopy thermogravimetry scanning electron microscope frontal displacement chromatography showed capacities anion exchangers tuned graphene amount hbcps layer count chromatographic performance graphene coated anion exchangers demonstrated separation inorganic anions organic acids carbohydrates amino acids good reproducibility obtained consecutive injections indicating high chemical stability coating published elsevier
advance reservation connections becoming increasingly important requirement many emerging commercial bandwidth scientific computing users however studies area focused scheduling algorithm design addressed implementation challenges larger realistic networking environments particularly multidomain result paper develops detailed solution distributed multidomain networks novel link state routing extensions update triggering policies introduced exchange inter domain bandwidth timeline state information distributed path scheduling algorithms designed leverage state schedule user requests across domains based upon various traffic engineering policies proposed solutions analyzed detail using network simulation
one world significant public health challenges low middle income countries hiv aids deserves treated appropriate medicines however spared counterfeiting developed screening specific hplc methods analyze antiretroviral medicines arv major excipients design experiments design space methodology initially applied arv excipients prediction thanks monte carlo simulations focusing rapidity affordability thus using short column low cost organic solvent methanol gradient mode buffer solutions ammonium hydrogen carbonate two specific methods dedicated arv liquid solid dosage formulations also predicted optimized checked ability one method analysis fixed dose combination composed emtricitabine tenofovir efavirenz tablet formulations satisfying validation results obtained applying total error approach taking account accuracy profile decision tool validated method applied test two samples coded claimed contain tested arv assay results satisfying sample elsevier rights reserved
large numbers british american reservists deployed operations iraq afghanistan little known impact deployment combat exposure violent behavior reservists purpose study determine prevalence self reported violent behavior among representative sample united kingdom reservists risk factors associated violence impact deployment combat exposure violence study used data large cohort study randomly selected military personnel included reservists service time sampling data collected questionnaires asked socio demographic military characteristics pre enlistment antisocial behavior deployment experiences post deployment mental health self reported interpersonal violent behavior prevalence violence among reservists deployment found risk factor violent behavior even adjustment confounders association violence similar deployed either combat role non combat role violence also strongly associated mental health risk factors ptsd common mental disorders alcohol misuse study demonstrated higher levels self reported post deployment violence reservists served either iraq afghanistan deployment irrespective role associated higher levels violent behavior among reservists results also emphasize risk violent behavior associated post deployment mental health problems aggr behav wiley periodicals inc
huge difference among universities located brazil happens mainly different development stage local industry well amount money invested local colleges particularly true courses demanding expensive laboratories well trained professors many brazilian states graduate opportunities offers engineering local community possible choice ones wish attend engineering master doctorate program move another city means sometimes travelling around brazil manaus capital amazonas state one distant cities lack advanced courses opportunities order solve problem one local school engineering institute education science technology amazonas ifam proposed two different programs together two best engineering schools brazil first one aimed one master degree mechanical materials engineering developed federal technological university parana based curitiba city second doctorate program electrical engineering together federal university minas gerais based belo horizonte paper goal present developed work discuss model education finding ways improve programs
paradigmatic system societal abuse occurs totalitarian state systems relational systems subjugation maintain states terror must necessity destroy authentic civic space individuals flourish similar dynamics characterize child abuse within families survival requires use varied strategies extreme dissociative nature result marked distortions developmental trajectories across psychological domains dynamics mirrored dissociative systems absence intervention perpetuate trauma non recognition subjugation self objectification omnipotent denial others subjectivity abusive systems facilitated bystanders whose awareness disavowed always partial resulting state knowing knowing dynamics shift bystanders may behave like victimspassive helpless frightened frozen like perpetratorstaking vicarious voyeuristic pleasure abuse actively aiding abetting abusers
paper describes development validation coupling methodology best estimate system thermal hydraulic code relap cfd code fluent conceived high fidelity plant scale safety analyses pool type reactors computational tool developed assess impact three dimensional phenomena occurring accidental transients loss flow lof research reactor myrrha currently design phase belgian nuclear research centre sck cen partitioned implicit domain decomposition coupling algorithm implemented coupled domains exchange thermal hydraulics variables coupling boundary interfaces numerical stability interface convergence rates improved novel interface quasi newton algorithm compared paper previously tested numerical schemes developed computational method assessed validation purposes experiment performed test facility tall operated royal institute technology kth sweden paper details results simulation loss forced convection test showing capability developed methodology predict transients influenced local three dimensional phenomena elsevier ltd rights reserved
objectives article describes translation evaluation star community consultants program star evidence based dementia caregiver training program within oregon department human services method staff two regional area agencies aging aaas trained implement aspects star including screening recruitment caregiver care receiver dyads treatment delivery mailed assessments caregiver depression burden care receiver mood behavior quality life collected pre treatment post treatment month follow results one hundred fifty one dyads entered program completed week intervention significant positive post treatment effects obtained caregiver depression burden reactivity behavior problems care receiver depression quality life month follow improvements caregiver reactivity care receiver depression maintained caregivers reported high levels satisfaction program discussion star successfully effectively implemented participating aaas recommendations replication including training recruitment assessment procedures provided
design horizontal axis wind turbine hawt blades involves several geometric complexities result modeling blades commercial computer aided design cad software easily accomplished present paper hawt blade divided structural aerodynamic surfaces continuity imposed connecting region widely used method skinning employed throughout current work surface approximation addition ensure compatibility section curves novel approach developed based redistribution input airfoil points order evaluate deviation errors hausdorff metric used fairness surfaces quantitatively assessed using standard strain energy method mentioned algorithms successfully integrated matlab program enhance optimization applications final surfaces created procedure developed present study exported using iges standard file format directly interpreted commercial cad software society computational design engineering publishing servies elsevier
distribution networks operated isolated neutral point capacitive earth fault current flows point fault case single phase earth fault magnitude current depends used type line scope network many reasons determining values capacitive earth fault current one important reasons distribution networks operation safety single phase earth fault necessary adhere allowed values touch voltage article written based knowledge long time experience acquired processing measurements distribution network described method verified real operation based results special purpose automatic system measurement capacitive earth fault current network isolated neutral point developed
paper parallel computing implementation multiagent coordination optimization mco algorithm introduced using parfor built matlab function novel variation particle swarm optimization pso mco algorithm demonstrated significant performance improvement terms accuracy efficiency solving real time optimization problems compared pso however ability handle large scale optimization problems use particles algorithm limited sequential implementation original mco algorithm numerical evaluation parallel mco algorithm conducted using supercomputers high performance computing center texas tech university based results evaluation determined performance parallel mco superior pso highly efficient reduces computational time parallel binary mco bmco algorithm presented well combining parallel mco parallel bmco algorithms new parallel mixed binary nonlinear programming mco solver proposed finally load balancing coordination problem multiagent formation control problem power system vulnerability analysis problem solved using corresponding parallel mco algorithm note practitioners optimization based techniques viewed great success industrial engineering applications rapid growth requirements optimization algorithms faster convergence higher accuracy heuristic optimization algorithms attracting attention proposed multiagent coordination optimization algorithm novel heuristic optimization algorithm created merging multiagent coordination swarm intelligence together accelerate search optimal solution moreover parallelization technique described paper greatly reduces computational time algorithm large scale optimization problems significantly benefits demand faster convergence higher accuracy solving complex large scale industrial problems load balancing coordination multiagent formation control power system vulnerability analysis
background ring chromosome syndrome rare chromosomal disorder characterized early onset refractory epilepsy intellectual disability autism spectrum disorder number diverse health issues results aim work provide recommendations diagnosis management persons affected ring chromosome syndrome based evidence literature experience health professionals different medical backgrounds followed several years subjects affected ring chromosome syndrome literature search performed original papers meta analyses reviews books guidelines reviewed final recommendations reached consensus conclusion conventional cytogenetics primary tool identify ring chromosome children terminal deletion chromosome ascertained molecular karyotyping cgh snp array tested secondarily conventional cytogenetics presence ring chromosome early diagnosis pursued order provide medical social assistance multidisciplinary team clinical investigations including neurophysiology epilepsy performed diagnosis within follow following diagnosis patients relatives caregivers receive regular care health social issues epilepsy treated onset anticonvulsive therapy likewise feeding difficulties treated according need nutritional assessment recommended patients nutritional support malnourishment include gastrostomy feeding selected cases presence autistic traits carefully evaluated many patients ring chromosome syndrome nonverbal thus maintaining ability communicate always essential every effort made preserve autonomy
refractive index crucial determining detailed nature propagation electromagnetic waves medium growing demand high resolution measurement refractive index newly synthesized materials usually small optical devices elements metamateirals miniaturized addition inhomogeneous broadening effects organic materials described mathematical dielectric models essential extract refractive index conventional spectroscopic measurements present novel method called surface plasmonometry extracts complex refractive index material using surface plasmons without dielectric models changing length nanoslot antennas various plasmon modes excited coupled target material becomes unique characteristic refractive index since optical parameters extracted wavelength machine learning algorithm mathematical dielectric models necessary furthermore table top fourier transform infrared source detector achieve times enhancement lateral resolution compared conventional ellipsometry owing extreme locality surface plasmon normal incidence geometry also successfully demonstrate label free detection protein bilayer surface plasmonometry opens exciting new biosensing platform
work assesses potential energy recovery byproducts biogas sludge produced laboreaux wastewater treatment plant wwtp itabira integrated uasb reactors trickling filters sludge dehydration unit filter press byproducts biogas sludge quantitatively production qualitatively composition calorific value characterized monitoring period months two scenarios energy recovery byproducts considered priority use biogas sludge thermal drying excess biogas used power generation internal combustion engine ice primary use biogas power generation heat engine exhaustion gases used sludge thermal drying biogas burning conditions combustion chamber internal combustion engine well mass energy balances scenario assessed chemcad software study analysed potential use byproducts sources renewable energy use wwtp offered third party scenario electricity generation lower fulfilling wwtp energy demand thermal drying allows greater reduction sludge volume disposed entire elimination final disposal dry sludge moisture content used fuel third party scenario electricity generation sufficient supply wwtp energy demand nevertheless heat contained exhausted gases enough dry whole dehydrated sludge configuring lower reduction sludge amount disposed mass reduction depending moisture reduction alternative chosen
paper discusses thermal influence long distance noncontact measurement suspension bridge three dimensional displacement use optical system composed digital camera infrared active targets computational support type measurement method optical propagation path light air range making measurement accuracy strongly dependent atmospheric refraction turbulence phenomena linked vertical temperature gradient camera targets addition adopted measurement geometrical configuration lead height difference two elements camera targets paper describes experimental setup procedure followed determination local temperature vertical gradients april bridge lisbon portugal optical measurement system applied obtained thermal measurements presented applied evaluation systematic refraction vertical deviation based appropriate mathematical models mentioned paper identification stable unstable observation thermal conditions related turbulence
susan hurley argued well known argument freedom speech argument autonomy basis two hypotheses violence media aggressive behaviour first hypothesis says exposure media violence causes aggressive behaviour second humans innate tendency copy behaviour ways bypass conscious deliberation argue first hurley successful setting aside argument autonomy second show empirical data irrelevant statutory regulation media violence yield sufficiently strong correlation exposure media violence non autonomously copied criminal violence yield way ante individuate viewers affected media violence
platycodon grandiflorum root derived saponins changkil saponins cks reported many pharmacological activities latest research cks proven significant osteogenic effect however detail molecular mechanism cks osteoclastic differentiation fully investigated administration cks considerably reduced ovx induced bone loss ameliorated reduction plasma levels alkaline phosphatase calcium phosphorus observed ovx mice cks also repressed deterioration bone trabecular microarchitecture interestingly platycodin abundant major pharmacological constituent triterpenoid cks inhibited receptor activator kappa ligand rankl induced activation kappa erk mapk ultimately repressing osteoclast differentiation ovx induced bone turnover attenuated cks possibly via repression osteoclast differentiation platycodin active component cks platycodin regarded antiosteoporotic candidate treatment osteoporosis diseases wiley periodicals inc
paper presents integrated bandgap reference circuit addressing low current consumption wide supply voltage range using current mode structure embedded sophisticated power management unit pmu gnss receiver bandgap reference output reach temperature coefficient ppm degrees range degrees degrees supply voltage power psrr frequency occupying chip area bandgap reference implemented cmos technology globalfoundries successfully validated lab
feminisms work correct social gender imbalance necessitating women continued self identification feminist several reasons noted women choosing identify exposure feminist beliefs education personal influences strong feminist role models awareness gender discrimination current research literature feminism largely omitted dynamic contextual factors may influence decision study sought fill gap utilizing qualitative methodology evaluate reasons contemporary women choose self identify feminist overall data indicate general desire equality empowerment freedom make choices instrumental decision making process exposure feminism education personal role models also led self identification implications findings well suggestions continuation feminist movement discussed
technological advances embedded computing exposed humans increasing intrusion computing day day life smart devices cooperation autonomy mobility made agent promising mechanism embedded devices work aims present new model embedded agent designed implemented smart devices order achieve parallel tasks distribute environment validate proposed model case study developed medical image segmentation using cardiac magnetic resonance image mri first part paper focus implementing parallel algorithm classification using means method embedded systems propose new concept distributed classification using multi agent systems based jade raspberry devices
based research conducted western australia part phd thesis article looks shifting boundaries gender roles australian muslim households highlights islamic stance biological differences men women basis understanding gender roles responsibilities also uncovers ideal influences contemporary muslim gender roles interplay social economic factors impact upon australian muslim households acculturation liberal western setting order capture nuances perceptions accounts participants research perceive providing caring roles household unit primary research uses narrative enquiry part methodology findings show variance textual injunctions contextual realties muslim women also become providers household shows congruence mainstream australian society also implications gender equality economic empowerment women approached diverse society like australia
heat transfer entropy generation magnetohydrodynamic flow alo water nanofluid porous vertical microchannel nonlinear radiative heat flux investigated numerically combined effects nanoparticle volume fraction hydrodynamic slip magnetic field suction injection thermal radiation heat transfer entropy generation studied dimensionless governing equations solved numerically applying runge kutta integration method together shooting technique study accuracy numerical results verified comparing predictions exact solutions model without radiation effects buoyancy force different previous literature heat transfer subject nonlinear thermal radiation joule heating viscous dissipation solved analyzed using conjugate convective radiative heat transfer boundary surfaces moreover influences pertinent parameters nanofluid velocity temperature local global entropy generation nusselt number discussed detail illustrated graphically based numerical results proved global entropy generation decreased nanoparticle volume fraction suction injection reynolds number increased grashof number buoyancy force intensity radiation parameter conduction radiation parameter addition possible determine optimum values slip flow minimum values global entropy generation rate nusselt number also calculated explored different conditions way optimum values grashof number maximum heat transfer heated left plate derived elsevier ltd rights reserved
parent report strengths difficulties questionnaire sdq widely used scale assesses children adolescents strengths difficulties present study applied scale italian adolescents compared current results previous chinese findings united kingdom norm participants italian parents adolescent children parents adolescents answered parent report self report sdq respectively results showed five factor first order model better competing models cronbach alpha emotional problems conduct problems hyperactivity peer problems prosocial behavior total difficulties respectively mother report measure respectively father report measure parent adolescent agreements ranged low medium whereas mother father agreements large parents rate boys girls well early adolescence mid adolescence differently italian parents rated adolescent children lower levels hyperactivity peer problems total difficulties higher levels prosocial behavior chinese parents italian mothers rated adolescent children lower levels hyperactivity united kingdom parents conclusion current findings suggest strengths inadequacies sdq italian adolescents
previous research reported serotonin receptor gene htra polymorphisms associated memory however unknown whether genetic variants associated true false memories current study han chinese subjects tested single nucleotide polymorphisms snps within htra gene potential associations true false memories false memories assessed using deese roediger mcdermott drm paradigm people falsely remember semantically related unpresented words found snps within htra gene associated true memory associations true memory seven adjacent snps still significant multiple testing corrections haplotype based association analysis revealed true memory positively associated haplotype seven adjacent snps still significant multiple testing correction one snp associated false memory significant multiple testing correction study replicates asian population genetic variation htra associated episodic memory also suggests association restricted true memory elsevier inc rights reserved
angioedema rapid swelling skin tissue typically triggered complex biochemical processes disrupt original steady state filtration liquid tissue swelling stabilizes new steady state achieved tissue significantly increased liquid content processes controlled events molecular cellular length scale describing consequences organ level length scales useful invoke consolidated continuum mechanics treatments within generalized hyperelastic framework describe challenges associated modeling demonstrate use context tracheal angioedema trachea modeled two layered cylindrical tube inner layer outer layer represent soft mucosal tissue stiffer cartilaginous tissue respectively axially oriented fibers contribute anisotropy inner layer swelling largely confined layer boundary value problem formulated existence uniqueness verified numerical solutions track airway constriction function mucosal swelling
background aims patients double temporary enterostomy may suffer intestinal failure parenteral nutrition gold standard treatment surgical reestablishment intestinal continuity chyme reinfusion technique consisting extracorporeal circulation chyme aims determine whether could restore intestinal absorption decrease needs improve nutritional status plasma liver tests feasibility home methods patients consecutively referred patients technical feasibility effectively treated included collected prospectively daily stomal fecal outputs coefficients nitrogen cnda fat cfda digestive absorption weight loss body mass index bmi nutritional risk index nri plasma albumin citrulline liver tests results patients temporary double enterostomy exposed enterocutaneous fistulas reduced intestinal output day improved cnda cfda normalized plasma citrulline concentration mol stopped patients within nutritional status improved weight bmi plasma albumin nri proportion patients plasma liver tests abnormalities decieased home feasible without serious complications selected patients conclusions corrected intestinal failure restoring intestinal absorption allowing weaning patients contributes improve nutritional status reduce plasma liver tests abnormalities feasible home elsevier ltd european society clinical nutrition metabolism rights reserved
many patients moderate severe mitral regurgitation subjected surgical therapy due multimorbidity patients mitraclipa implantation therapeutic alternative aim article present recommendations treatment mitraclipa procedure purpose selective literature review carried based current literature notably national international guidelines mitraclipa procedure rehabilitation indicated underlying heart failure well treatment heart valve optimization drug therapy implementation standardized heart failure training initiation strength endurance training psychosocial support initiated patients briefed endocarditis prophylaxis lasting least six months furthermore according current guidelines treatment ace inhibitors beta blockers aldosterone antagonists optimized special feature anticoagulation currently empirically accounted performed sinus rhythm typically four weeks dual antiplatelet therapy aspirin clopidogrel followed monotherapy aspirin atrial fibrillation lifelong oral anticoagulation indicated combined platelet aggregation inhibitor four weeks particular echocardiographic control rehabilitation clinic cardiologists focused residual atrial septal defect transmitral gradient residual mitral regurgitation
phosphodiesterase inhibitors sildenafil increase intracavernosal cyclic guanosine monophosphate levels results corporal smooth muscle relaxation penile erection determined effects sildenafil administration hypothalamic pituitary gonadal axis men erectile dysfunction low testosterone levels testosterone erectile dysfunction trial clinicaltrials gov nct initially administered optimized dose sildenafil men aged years erectile dysfunction low serum total testosterone nmol free testosterone pmol weeks sex steroids gonadotropins measured baseline sildenafil optimization longitudinal study without separate control group serum testosterone dihydrotestosterone dht oestrogens measured using liquid chromatography tandem mass spectrometry administration optimized dose sildenafil associated mean increases nmol pmol total free testosterone levels respectively accompanied parallel increases serum dht nmol oestradiol pmol significant suppression luteinizing hormone change units levels suggesting direct effect testicular level androstenedione oestrone increased nmol pmol respectively supporting possible effect sildenafil adrenal steroidogenesis conclusion sildenafil administration associated increased testosterone levels likely ascribable direct effect testis
investigated proposal ankylosing spondylitis associated unusual erap genotypes erap haplotypes constructed cases rheumatoid arthritis controls using family data haplotypes generated five common erap single nucleotide polymorphisms snps haplotype frequencies compared using fisher exact test erap haplotypes imputed international genetics consortium igas immunochip study also studied family study identified four common erap haplotypes vrnqe mkdrq mrdre mkdre cases controls apart two rare previously unreported haplotypes examples unusual erap haplotype combination previously reported others cases expected bearing haplotypes increased family study control due particularly increase mkdrq haplotype control trend replicated imputed immunochip data two bearing haplotypes mkdrq controls mkdre controls erap association therefore predominantly attributable common erap haplotypes haplotype combinations
inverse relation serotonin human aggression often portrayed reliable strong well established despite decades conflicting reports widely recognized methodological limitations systematic review meta analysis evaluate evidence serotonin deficiency hypothesis human aggression across methods assessing serotonin cerebrospinal fluid levels hydroxyindoleacetic acid csf hiaa acute tryptophan depletion pharmacological challenge endocrine challenge results across independent samples total participants heterogeneous aggregate revealed small inverse correlation serotonin functioning aggression anger hostility pharmacological challenge studies largest mean weighted effect size csf hiaa studies smallest potential methodological demographic moderators largely failed account variability study outcomes notable exceptions included year publication effect sizes tended diminish time self versus reported aggression reported aggression positively correlated serotonin functioning discuss possible explanations pattern findings unreliable measures ambient correlational noise unidentified higher order interaction selective serotonergic effect finally provide recommendations bringing much needed clarity important area research acknowledge contradictory findings avoid selective reporting practices focus improving reliability validity serotonin aggression measures test interactions involving personality environmental moderators revise serotonin deficiency hypothesis account serotonin functional complexity
problem bus system testability modeling character bidirectional information transmission put forward method testability modeling bus system based multi signal flow graph basis analyzing bus topology information transmission mechanism fault mode bus construct multi signal flow graph model bus system modeling redundancy bus structure multi dimension function attribute definition multi work mode test item definition finally analyzing example proved effectiveness multi signal flow graph constructed paper
present first public release open source gadget dataframe library gadfly aim package leverage capabilities broader python scientific computing ecosystem providing tools analyzing simulation data astrophysical simulation codes gadget gizmo using pandas thoroughly documented open source library providing high performance easy use data structures quickly becoming standard data analysis python gadfly framework analyzing particle based simulation data stored hdf format using pandas dataframes package enables efficient memory management includes utilities unit handling coordinate transformations parallel batch processing provides highly optimized routines visualizing smoothed particle hydrodynamics data sets
embryonic liver unique external morphology quantitative morphometry based magnetic resonance imaging data human embryos kyoto collection human embryos liver morphogenesis strongly affected adjacent organs tissues left ventricle develops left medial caudal side results formation depression left medial region prominence bilaterally cranial surface liver carnegie stage imprint stomach formed dorsal left medial region liver became marked development depression induced umbilicus formed ventral region liver indentation caused right adrenal gland formed dorsal caudal region liver surface morphometric analysis revealed volume liver increased exponentially liver developed preferentially along dorsoventral axis right left axis along craniocaudal axis directions several important developmental phenomena differentiation diaphragm extension body axis embryo physiologic herniation intestine umbilical cord may affect morphometric data data contribute better understanding liver development well morphogenesis adjacent organs temporally spatially serve useful reference fetal medicine prenatal diagnosis anat rec wiley periodicals inc
backgroundstudies male combat veterans suggested posttraumatic stress disorder ptsd associated shorter telomere length examined cross sectional association ptsd women exposed traumas common civilian life methodsdata substudy nurses health study ptsd subclinical ptsd assessed trauma exposed women using diagnostic interviews array health behaviors conditions assessed dna extracted peripheral blood leukocytes collected telomere repeat copy number single gene copy number determined quantitative real time pcr telomere assay used linear regression models assess associations examine whether range important health behaviors cigarette smoking medical conditions hypertension previously associated might explain ptsd association examined whether type trauma exposure interpersonal violence associated whether trauma type might explain ptsd association resultsrelative ptsd women ptsd diagnosis shorter log transformed confidence interval adjustment health behaviors medical conditions attenuate association trauma type associated account association ptsd conclusionsour results add growing evidence ptsd may associated rapid cellular aging measured telomere erosion moreover association could explained health behaviors medical conditions assessed study type trauma exposure
substance use depression prevalent among mothers enrolled home visiting programs significant risk factors child maltreatment yet home visiting programs staffed workers lack training clinical skills address risks emanating one state network interest advancing practice area current study surveyed home visitors current practices training knowledge perceived self efficacy perceived system client level barriers regarding client substance use depression home visitors reported managing maternal depression extensively substance use though overall management risk areas low training associated extensive management risk domains greater home visitor knowledge self efficacy implications development strategies improve home visitor management client behavioral health risks including enhanced skills based training supervision discussed
negative impact overactive bladder chronic pelvic pain syndrome quality life patients well known neurostimulation posterior tibial nerve tens validate therapeutic approach treatment overactive bladder chronic pelvic pain syndrome good results despite lack evidence high level study absence side effect allow common use context pathology taken multiple load elsevier masson sas rights reserved
paper describes experimental study workers responses proximity warnings static safety hazards construction sites using location based proximity warning system named proactive construction management system pcms method evaluating workers responses proximity warnings proposed method consists six variables warning time distance time minimum distance hazard worker receives warning dangerous time distance time minimum distance hazard worker comes close hazard response time distance difference dangerous time warning time difference dangerous distance warning distance finally whether worker responds warning evaluated two second threshold two meter threshold terms response time distance respectively experiment conducted workdays participation workers resulted warnings real life construction project shanghai china workers responses analyzed respect two factors building trades priori risk levels research found workers responded proximity warnings actively slightly differently across selected building trades carpenters longer response latency hazardous areas ironworkers response percentages high hazardous areas high risks results also show evidence pcms potential improve workers safety performance limitations present study future research directions also addressed elsevier ltd rights reserved
hereditary neurodegenerative diseases present psychiatric prodrome overlaps psychiatric symptoms primary diseases individuals present predictive testing experiencing symptoms clinicians including genetic counselors must proceed caution evaluate situation case case basis legitimate reasons may exist moving forward testing additionally predicting consequences testing unrealistic clinicians must best prepare patients positive negative results multidisciplinary team following huntington disease protocol remains gold standard care predictive testing patients discuss case histories demonstrate complex nature genetic counseling testing presence psychiatric symptoms whether emanating disease results living affected family
necrotizing scleritis severe destructive form scleritis vision threatening sequelae divided inflammation without inflammation scleromalacia perforans adalimumab tumour necrosis factor tnf inhibiting anti inflammatory medication licensed treatment rheumatoid psoriatic arthritis ankylosing spondylitis inflammatory bowel disease usa report two cases necrotizing scleritis successfully treated adalimumab
surveillance plays crucial role day day life typical surveillance system continuously monitors vicinity stores surveillance data locally may end lots memory energy wastage moreover surveillance records security threat surveillance system seized damaged intruders paper new design surveillance using smartphone along passive infrared pir sensor microcontroller unit mcu proposed pir sensor attached smartphone mcu detect motion video captured motion detected short message services alert sent user straight away overcome memory restrictions smartphone ensure safe storage surveillance records uploaded cloud link sent user email proposed intelligent surveillance system offers cost effective storage effective energy efficient secured solution uses computation communication capabilities smartphone storage capabilities cloud
aim paper describe method analysing test data recorded hopkinson bar bending test three point dynamic bending test designed testing strength materials dynamic loads carried specimen consisting beam placed two supports subjected impact use hopkinson bar supports makes possible determine forces displacements points analytical solution transient response long beam subjected transverse impact used determine impact force displacement procedure applies first instants motions generated impact yet reached supports mechanical state specimen identical unsupported beam suitable use quasi brittle materials failure occurs beginning test material strength determined time failure characterised sudden decrease bending moment results test quasi brittle material loaded failure presented analysed outlined results obtained confirm relevance present method elsevier ltd rights reserved
background investigated identifying patients mild cognitive impairment mci progress alzheimer disease mci converter mci mci progress mci non converter mci based resting state fmri fmri new method graph theory machine learning approach utilized predict progress patients mci using fmri eighteen mci converts average age years male age matched mci non converters average age years male included study trained tested support vector machine svm classify mci mci using features constructed based local global graph measures novel feature selection algorithm developed utilized select optimal subset features results using subset optimal features svm classified mci mci accuracy sensitivity specificity area receiver operating characteristic roc curve respectively furthermore results statistical analyses used identify affected brain regions comparison existing method best knowledge first study combines graph measures constructed based fmri machine learning approach accurately classify mci mci conclusion results study demonstrate potential proposed approach early diagnosis demonstrate capability fmri predict conversion mci identifying affected brain regions underlying conversion elsevier rights reserved
background prevalence type diabetes mellitus diabetes nursing home residents nhrs increasing concurrently obesity comorbid conditions nhr would benefit greatly antidiabetic medications would improve glycemic control give lower risk hypoglycemia contribute weight gain obese individuals objective examine prescription patterns nhrs diabetes including use newer injectable therapies glucagon like peptide glp receptor agonists methods treatment patterns diabetes nhr analyzed using minimum data set records prescription claims omnicare senior health outcomes data repository may september results prevalence diabetes population nhrs among nhrs diabetes prescription claims data prevalence obesity multiple comorbidities high approximately nhrs diabetes aged followed oral agents glp receptor agonist use low associated poor treatment persistence conclusion considerations glycemic control may drive prescribing decisions contrary recommendations american diabetes association american medical directors association european association study diabetes
recovery movement paradigm shift mental health care recognizes individuals diagnosed even debilitating long standing disorders may still lead meaningful fulfilling lives symptom reduction part recovery process article discuss principles recovery recommendations concerning application principles treatment individuals trauma related difficulties improve hope meaning overall quality life conclude identifying diagnostic treatment approaches consistent principles recovery discuss practitioners incorporate recovery principles evidence based care planning
paper presents developed methodology detection bovine milk adulteration applying electrical impedance measurements parameter allows characterizing samples raw ultrahigh temperature milk adulterated different proportions drinking water deionized water hydrogen peroxide sodium hydroxide naoh formaldehyde cho samples electrically analyzed applying electrical impedance spectroscopy measurements dedicated microcontroller system developed application cases measures allowed classifying milk quantitatively enabling development real time monitoring systems fraud detection milk composition classification results proposed nearest neighbors algorithm allows quantitatively qualify samples pure adulterated milk
study reports assessment vibrational serviceability performance parallel cable stayed bridge subjected vortex induced vibration viv identifying modal damping ratios operational monitoring data obtained natural excitation technique next combined eigen realization algorithm era applied output modal analysis parameters regarding next era procedures determined sensitivity analysis identified damping ratios multiple tuned mass damper mtmd installed center main span mitigate viv modal damping ratios installation mtmd also compared several sets operational monitoring data collected various windy conditions used develop relationship identified damping ratios corresponding viv level bridge basis findings performance bridge enhanced regarding vibrational serviceability american society civil engineers
rapid urbanization dramatically changes local environment hybrid classification method designed applied multi temporal landsat images ancillary data obtain land cover change datasets support vector machine svm classifier used classify multi temporal landsat enhanced thematic mapper plus etm images collected pixel level images also segmented mean shift method impervious surface refined based combination segmented objects svm classification results changed areas determined comparing thematic mapper etm images via weighted multivariate alteration detection transformation method images masked changed areas input svm classifier land cover maps produced combining unchanged area new classes changed areas land cover change continuously accelerated since remarkably arable land decreased impervious surface area significantly increased
purpose study evaluate choroidal thickness patients psoriasis using enhanced depth imaging optical coherence tomography edi oct determine relationship psoriasis activity indices prospective study edi oct images obtained consecutive patients psoriasis age gender matched healthy individuals comprehensive ophthalmic examination edi oct evaluation performed measured subfoveal area correlation analyses performed identify relationship disease duration clinical disease activity score total individuals evaluated study psoriasis controls mean disease duration patients psoriasis years years difference groups respect age gender respectively five patients psoriasis anterior uveitis none patients psoriasis signs posterior uveitis significantly higher psoriasis group control subjects mean central foveal thickness comparable groups also significant correlation edi oct disease activity score disease duration choroidal thickness increased psoriasis patients large serial comparative studies necessary evaluate edi oct examination may helpful understanding effects psoriasis eye pathophysiology
field weapon system systems wsos simulation various indicators widely used describe capability wsos always difficult describe comprehensive capability wsos quickly intuitively visualization multi dimensional indicators method machine learning visualization proposed display analyze capabilities different wsos two dimensional plane analysis comparison comprehensive capability different components wsos realized method consists six parts multiple simulations key indicators mining three spatial distance calculation fusion project calculation calculation individual capability density calculation multiple capability ranges overlay binding simulation experiment collaborative analysis six indicators possible kinds red wsos achieved experimental results show method effectively improve quality speed capabilities analysis reveal large number potential information provide visual support qualitative quantitative analysis model
paper tribute tercentenary leibniz death aristotle one impressive original accomplishments building rational knowledge nature found leibniz dynamics furthermore science motion occupies prominent place thought addition theoretical developments leibniz designed calculating machine performed four arithmetic operations worked mining engineer harz germany design construction windmills paper leibniz contributions machine science namely dynamics machine design presented discussed
objectivesto investigate effect descending serotonergic noradrenergic pathways nociception lower urinary tract lut methodsfemale sprague dawley rats used following intraperitoneal administration vehicle milnacipran one serotonin noradrenaline reuptake inhibitors snri infused bladder normal spinal cord injury sci rats consciousness fos stained using immunohistochemistry spinal cord spinal areas associated lut resultsin sci rats positive fibers observed spinal cord many positive fibers normal rats total number fos positive cells significantly increased sci rats compared normal rats normal sci indicated interruption supraspinal modulation enhances nocieptive transmission lut regarding effect milnacipran administration number fos positive cells significantly decreased region spinal cord normal rats reduction observed sci rats result demonstrated administration snri attenuates nocieptive transmission lut indicating noradrenaline work mediators endogenous analgesic mechanisms supraspinal descending pain pathways conclusionssupraspinal projections descending serotonergic noradrenergic pathways lower lumbar spinal cord modulate nocieptive transmission lut administration snri attenuates nocieptive transmission lut could result enhancement modulating descending serotonergic noradrenergic pathways
paper addresses day ahead network constrained thermal unit commitment problem uncertainty problem electrical network considered power flow model phase angles represented directly model associated flow limit constraints dynamically introduced iterative process uncertainty regards stochastic demand supplied thermal plants possibly due configuration high wind penetration two main contributions presented first new compact mixed integer formulation unit commitment constraints minimum times defining multi node constraints comprise integer variables related nodes given sub trees original scenario tree second application local branching strategy instead standard branch cut algorithm solve problem computational experiments carried ieee buses system assuming severe constraints transmission lines capacities two scenarios trees hour period
wireless technologies combined advanced computing changing industrial communications industrial wireless networks improve monitoring control entire system jointly exploiting massively interacting communication distributed computing paradigms paper develop wireless cloud platform supporting critical data publishing distributed sensing surrounding environment cloud system designed self contained network interacts devices exploiting time synchronized channel hopping protocol tsch supported wirelesshart iec cloud platform augments industry standard networking functions handles delivery publishing latency throughput critical data implementing cooperative multihop forwarding scheme addition supports distributed sensing functions consensus based algorithms experimental activities presented show feasibility approach two real industrial plant sites representative typical indoor outdoor environments validation cooperative forwarding schemes shows substantial improvements compared standard industrial solutions distributed sensing functions developed enable autonomous identification recurring cochannel interference patterns
paper describes flexible scalable architecture remote laboratories developed students experimentation educational institutions research labs technology companies framework procedures multi remote labs environment explained development lab client software rich internet application ria described utilization low cost hardware software packages provide interface labs equipment shown deployment web services communication medium lab server lab client presented case study remote lab microcontroller kit remote ide carried student connect remote lab performs experiment watching equipment execution via webcam feed whole lab accessible connected internet
study designed compare pull strength simple suture stitches human supraspinatus tendons respect position rotator cable fifty four tests performed intact human supraspinatus tendons assess cutout strength simple suture configuration different positions medial lateral within rotator cable tendon thickness measured correlated positioned suture suture positioning lateral rotator cable showed significantly lower suture retention properties compared positioning suture medial cable tested specimens central stitch row medial rotator cable provided optimum retention properties mean even correcting tendon thickness study shows desirable identify rotator cable pass sutures medial close middle tendon provided highest possible suture retention properties
following multivariant analysis demonstrated children adolescents burkitt lymphoma deletion significant decrease event free survival efs despite identical short intensive multi agent chemotherapy however deletion region associated significant decrease efs children adolescents largely unknown gene deleted lymphocytic leukemia dleu located region report dleu expression implicated regulation programmed cell death cell proliferation expression apoptotic genes transcription activator like effector nuclease talen induced dleu knockdown dleu overexpressing cell lines furthermore nsg mice xenografted dleu knockdown cells significantly shortened survival whereas xenografted dleu overexpressing cells significantly improved survival following treatment rituximab cyclophosphamide data suggest dleu may part function tumor suppressor gene confer chemoimmunotherapy resistance children adolescents
context subacute thyroiditis sat transient inflammatory disease occurs often upper respiratory tract infection permanent hypothyroidism ratio reported sat patients objective study tried compare treatment options permanent hypothyroidism sat patients design retrospective study medical records sat patients analysed subjects methods medical records patients analysed demographic data laboratory clinical course treatment year outcome patients classified steroid nonsteroidal anti inflammatory drugs nsaid steroid nsaid groups results male female ratio similar female domination demonstrated groups steroid nsaid groups pretreatment thyroid function tests diagnosed hyperthyroidism steroid nsaitd group diagnosed hyperthyroidism beginning groups thyroid function tests normal levels one year later groups erythrocyte sedimentation rate esr reactive protein crp levels increased pretreatment period decreased treatment total right lobe involvement thyroiditis detected permanent hypothyroidism observed steroid nsaid steroid nsaid groups respectively conclusion study treatment drug option affect permanent hypothyroidism one year sat patients
neurotrophin receptor pntr low affinity receptor capable binding neurotrophins two different pntr knockout mouse lines available either deletion exon iii pntr exiii exon pntr exiv pntr exiii knockout mice full length pntr deleted whereas pntr exiv knockout mice full length well truncated isoform receptor deleted deletion pntr shown affect among others septohippocampal cholinergic innervation pattern neuronal plasticity within hippocampus hypothesize deletion pntr also alters morphology physiology key structure limbic system amygdala results indicate deletion pntr also increases cholinergic innervation basolateral amygdala adult well aged pntr exiii pntr exiv mice pntr exiv mice display altered long term potentiation ltp basolateral amygdala compared age matched control littermates however pntr exiii mice display stronger ltp basolateral amygdala compared age matched controls bath application trk antagonist inhibit induction ltp basolateral amygdala reduced level ltp pntr exiii mice levels seen respective controls moreover pntr exiii mice display altered behavior dark light box thus deletion pntr mice leads physiological morphological changes amygdala altered behavior linked limbic system
aim determine functional role mir mast cell proliferation apoptosis mast cell tryptase par signal pathway methods generation lentivirus vector systems containing enhanced green fluorescent protein egfp ruisai inc shanghai china acts reporter gene used construct mmu mir lentivirus expression vector pegfp antagomir lentivirus vector pegfp negative used negative control stably transfected mast cell line constructed gfp positive cells successfully transfected cells determined expression mir mast cells transfection using quantitative real time pcr qrt pcr addition transduction lentivirus vectors role mir mast cell proliferation apoptosis investigated using cck assay flow cytometry respectively mrna levels tryptase par detected qrt pcr protein levels detected western blot results inhibition mir expression promoted apoptosis inhibited proliferation mast cells mrna levels tryptase par significantly increased transfection compared control group tryptase normal null sirna normal sirna null par sirna null normal null sirna normal protein levels tryptase par slightly higher sirna group control group difference statistically significant conclusion mir plays vital role pathogenesis irritable bowel syndrome affecting mast cell proliferation apoptosis regulation mir mrna level mast cell tryptase par increased protein level increased difference statistically significant
accurate simulation fuel properties influence performance internal combustion engines complex subject combines many physical chemical concepts combustion phenomena chemical kinetics fluid dynamics turbulence thermodynamics order circumvent complexity concepts many simulations packages engine performance usually consider standard surrogate fuels might enough new fuel developments cases study aims evaluate influence different formulations gasoline behavior flexible fuel engine relating physicochemical properties fuels performance efficiency gaseous emissions based experimental dataset metamodels generated using different radial basis functions kriging techniques order accurately predict torque fuel consumption specific fuel consumption global efficiency emission twelve blends iso octane heptane toluene ethanol different engine speeds load conditions leave one cross validation procedure applied automatically select best metamodel case metamodels able estimate experimental results five fuels within confidence intervals prediction residuals lower elsevier ltd rights reserved
clinical guidelines recommend addressing adolescent alcohol use primary care ask advise assess assist arrange may useful model intervention audio recorded visits physicians adolescents compared alcohol disclosure rates encounter survey analyzed conversations use relation adolescent reports drinking months encounter physicians asked clear nonleading questions drinkers likely disclose alcohol use visits alcohol discussed physicians used one frequently ask physician used among drinkers association physicians partial use adolescent alcohol consumption months physicians learn effective ways ask alcohol use increase disclosure drinking comprehensive counseling
developmental dysplasia hip ddh common musculoskeletal disorder characterized mismatch acetabulum femoral head mechanical force plays important role occurrence development abnormities acetabulum femoral head study established mechanical force model named cyclic compressive stress ccs analyze effect ccs ddh detected special genes chondrocytes osteoblasts results showed ccs downregulated chondrogenesis adtc concentration dependent manner moreover mrna level scinderin scin considerably increased established lentivirus scin scin transfect hbmscs treated different ccs levels result showed overexpression scin upregulated osteogenesis osteoclastogenesis contrast expression chondrocyte specific genes including acan col sox decreased molecular investigation demonstrated scin promoted osteogenesis osteoclastogenesis activation smad kappa mapk signaling pathways well stimulated expression key osteoclast transcriptional factors nfatcl fos moreover scin induced osteogenesis outweighed osteoclastogenesis defective femur vivo results analysis micro confirmed findings overall ccs influenced development ddh promoting osteogenesis cartilage degradation addition scin played vital role development ddh elsevier inc rights reserved
objective cognitive remediation programs often larger effects cognition compared everyday outcomes compared changes across cognitive functional competence vocational domains cognitive remediation programs method sequential enrollment nonrandom design individuals serious mental illnesses psychotic mood disorders community vocational rehabilitation program action based cognitive remediation abcr new program combines traditional cognitive training techniques simulated workplace situations goal setting engaging cognitively demanding activities completers compared traditional cognitive remediation tcr completers groups met twice weekly sessions weeks repeated measures analysis variance used examine effects pre posttreatment weeks treatment univariate analysis variance chi square tests used compare work outcomes months intervention results significantly abcr participants retained intervention compared tcr reported greater increases perceived competence cognitively challenging tasks eta abcr effects significantly larger tcr functional competence eta smaller nonsignificant differences social cognition eta neurocognition eta abcr participants marginally likely competitively employed among employed abcr participants experienced less job related stress eta conclusions implications practice cognitive rehabilitative programs serious mental illness rely computer based training neuroplasticity ensure opportunities active skill development therapist supported techniques overcome challenges generalizing cognitive effects everyday outcomes
dry forests latin america among dynamic deforestation frontiers world important carbon biodiversity reservoirs knowledge spatial patterns deforestation proximate drivers remains partial though used full landsat image archive reconstruct deforestation post deforestation dynamics entire paraguayan chaco deforestation rampant recently classification resulted reliable land use change maps highlighting drastic forest losses almost equaling deforestation rate yearly predominantly grasslands likely represented new pastures making pasture expansion dominant proximate cause deforestation cropland expansion contrast played minor role proximate deforestation cause paraguayan chaco deforestation doubled similar compared similar due leakage effects deforestation ban paraguayan atlantic forests interestingly grasslands expanded paraguayan chaco cattle numbers decreased time period though strongly increased since apparent decoupling area change land use intensity may indicate paraguayan chaco experienced amplification period followed intensification period since thus results highlight need detailed monitoring post deforestation dynamics land systems perspective order understand deforestation frontiers thus ultimately identify strategies better balance production conservation goals
last years wide variety automatic network layout algorithms developed fast heuristic techniques suitable networks hundreds thousands nodes others multi stage frameworks higher quality layout smaller networks however despite decades research currently algorithm produces layout comparable quality human give new human centred methodology automatic network layout algorithm design intended overcome deficiency user studies first used identify aesthetic criteria algorithms encode algorithm developed informed criteria finally follow study evaluates algorithm output used new methodology develop automatic orthogonal network layout method hola achieves measurably better user study layout best available orthogonal layout algorithm produces layouts comparable quality produced hand
alternating flows ground detrimental effect internal stability ground bottom bodies water offshore structures coastal protection structures revetments test apparatus alternating flow constructed purpose investigating various problems relating alternating flow ground used conduct investigations stability granular filters offshore wind turbines subjected high levels alternating hydraulic loads design criteria granular filters subjected oscillating loads must considerably stringent granular filters subjected unidirectional flow also possible demonstrate hydraulic loads due waves significant effect filter stability area relevant offshore structures
significant advances health social wellbeing led linear gains life expectancy accompanying increase burden imposed age related morbidities complex alterations hormonal networks regulate homeostasis survival may underlie poor adaptation later life exemplified increased fracture risk amongst post menopausal women beyond overt overactivity hormonal axes changes concentrations regulatory hormones may also impact health disease subclinical hyperthyroidism disorder characterised normal thyroxine levels presence decreased thyroid stimulating hormone instance independently associated increased risk atrial fibrillation amongst elderly populations menopause subclinical thyroid disease demonstrate difficulty reversing endocrine changes later life minimal impact thyroxine therapy subclinical hypothyroidism multiple reports harm resulting hormone replacement therapy peri post menopausal women given findings strategies locally regulate hormone bioavailability altering pre receptor metabolism may offer greater therapeutic potential fight age related disease review aims provide overview ageing endocrine system potential impact health disease elderly postulate strategies coordinate pre receptor hormone metabolism greater understanding putative hormonal longevity pathways may offer key new drug targets fight ageing argue applying conventional endocrine maxim block replace hormonal changes seen ageing karger basel
galloping tensioned orthotropic saddle closed membrane structure theoretically investigated paper aerodynamic force acting membrane surface determined potential flow theory fluid mechanics thin airfoil theory aerodynamics based von karman large amplitude theory alembert principle interaction governing equations wind structure coupling established applying bubnov galerkin method complicated interaction equations transformed second order nonlinear differential equation constant coefficients judging stability second order nonlinear differential equation critical wind velocity obtained parametric analysis analytical examples conclude great significance consider orthotropy geometrical nonlinearity prevent aerodynamic instability saddle membrane structures arch span ratio epsilon span ratio main control parameters critical wind velocity formula critical wind velocity obtained paper provides accurate theoretical solution aerodynamic stability saddle membrane structures previous studies
primary european car makers agree embedded supply support growing current load requirements modern vehicles functionalities required starter generator engine start launch assistant torque regenerative braking battery charging early fuel cut dynamic load profile harsh environment working conditions make thermal issues key challenge machine design paper presents simulation experimental test results belt driven starter generator mini hybrid powertrains particular double three phase induction machine selected suitable candidate application detail authors illustrate experimental calibration validation steady state thermal model well thermal characterization liquid cooled prototype finally paper deals temperatures prediction motor working different load conditions
microevolutionary mechanisms resistance bacterial pathogen explored population greater wax moth galleria mellonella selected fold increased resistance entomopathogenic bacterium bacillus thuringiensis compared non selected suspectible line defense strategies resistant susceptible insect lines compared uncover mechanisms underpinning resistance possible cost survival strategies uninfected state resistant insects exhibited enhanced basal expression genes related regeneration amelioration toxin activity midgut addition insects also exhibited elevated activity genes linked inflammation stress management immune defense fat body following oral infection expression genes elevated fat body midgut lines greater extent resistant line susceptible line gene expression analysis reveals pattern resistance mechanisms targeted sites damaged insect placing greater emphasis tissue repair revealed elevated expression genes fat body midgut epithelium unlike susceptible insects infection significantly reduced diversity richness abundance gut microbiota resistant insects observations suggest resistant line intact midgut secreting antimicrobial factors gut lumen mitigate activity also affects viability gut bacteria remarkably resistant line employs multifactorial adaptations resistance without detected negative trade since insects exhibited higher fecundity
recently introduced concept power domination generalizes domination power domination latter concept used monitoring electric power system power domination problem determine minimum size vertex subset graph setting iteratively adding vertices neighbour neighbours yet get paper power domination number sierpia ski graphs determined propagation radius introduced measure efficiency power dominating sets propagation radius sierpia ski graphs obtained cases
use language signal flow graph representation digital filter structures solve three purely mathematical problems including fast inversion certain polynomial vandermonde matrices deriving analogue horner clenshaw rules polynomial evaluation quasiseparable basis computation eigenvectors quasiseparable classes matrices algebraic derivations possible using elementary operations specifically flow reversal signal flow graphs provides unified derivation reveals connections systems theory etc elsevier inc rights reserved
objectives ineffective contraceptive use among young sexually active women extremely prevalent poses significant risk unintended pregnancy ineffective contraception involves use withdrawal method inconsistent use types contraception condoms birth control pills investigation examined violence exposure psychological factors related ineffective contraceptive use among young sexually active women materials methods young nonpregnant sexually active women recruited urban family planning clinic participate longitudinal study tablet based surveys measured childhood violence community level violence intimate partner violence depressive symptoms self esteem followup surveys measured type consistency contraception used months later multivariate logistic regression models assessed violence psychological risk factors main effects moderators related ineffective compared effective use contraception results multivariate logistic regression model showed childhood sexual violence low self esteem significantly related ineffective use contraception adjusted odds ratio aor confidence interval aor respectively although self esteem moderate relationship childhood sexual violence ineffective use contraception aor depressive symptoms related ineffective use contraception multivariate model conclusions interventions reduce recognize long term effects childhood sexual violence address role low self esteem ability young sexually active women effectively consistently use contraception prevent
background prognostic value heart failure specific global health status left ventricular assist device lvad implantation usual care setting well studied methods included continuous flow lvad patients intermacs registry health status measured pre operatively months post lvad using kansas city cardiomyopathy questionnaire kccq euroqol visual analog scale vas primary outcomes mortality rehospitalization inverse propensity weighting used minimize bias missing data results pre operative global heart failure specific health status poor kccq median iqr vas median interquartile range iqr health status measures improved months lvad placement kccq median iqr vas median iqr pre operative health status associated death unadjusted lowest highest score quartiles kccq vas rehospitalization unadjusted kccq vas three month kccq associated mortality unadjusted vas three month kccq added incremental discriminatory value heartmate risk score death stat vas stat three month health status associated rehospitalization unadjusted kccq vas add incremental discriminatory value stat respectively conclusions real world data suggest pre operative health status limited association outcomes lvad however persistently low health status surgery may independently signal higher risk subsequent death study needed determine clinical utility routinely collected health status data lvad implantation
paper reports findings exploratory qualitative study using implementation wenger communities practice learning meaning identity cambridge cambridge university press wenger communities practice social learning systems organization theory communities practice develop accounting community practice acop pedagogy students eight accounting courses participated narratives surveys used data practice develop critical real world professional accounting competencies linking three structural foundations accountability joint enterprise mutual engagement shared repertoire communal resources competencies promoted aicpa core competency framework entry accounting profession retrieved http www aicpa org edu corecomp htm aicpa core competency framework entry accounting profession retrieved http www aicpa org edu corecomp htm international federation accountants ifac international education standard professional skills retrieved www ifac org ifac meeting future expectations professional competence consultation iaesb future strategies priorities retrieved www iaesb org icaew added value professionals chartered accountants england wales london author professional bodies include problem solving leadership project management interaction acop strategy effective maintaining dynamic learning environments increasing students awareness trust open communication creative thinking meaning knowledge owned acop focus class shifts instructor students study adds limited empirical research communal forms learning accounting
background several studies documented lower scores momingness eveningness questionnaire meq associated higher global seasonality mood gss modern man artificial lighting predominantly extends evening activity exposure light evening bright light phase known delay circadian rhythms chronic exposure could potentially lead lower momingness well higher gss aim study investigate meq gss relationship holds old order amish lancaster county population use network electrical light methods old order amish adults women average age years completed seasonal pattern assessment questionnaire spaq assessment gss meq associations gss scores meq scores analyzed using linear models accounting age gender relatedness including relationship matrix model random effect results gss inversely associated meq scores adjusted limitations include potential recall bias associated self report questionnaires actual light exposure measurements conclusion confirmed previously reported inverse association meq scores lower seasonality mood first time population use home network electrical lighting result suggests association byproduct exposure network electric light calls additional research investigate mechanisms momingness negatively associated seasonality published elsevier
induction electric motor develops transient processes significant sized electromagnetic torques several times exceeding rated starting even maximum ones torques reason occurrence dangerous mechanical stresses elements kinematic chain electromechanical system considered assessing reliability operation electric drive nature flow transient processes electrical machine often determines behavior entire system element machine paper deals transient processes starting powerful electric drive pump unit influence supply voltage total torque inertia electric drive arising impact torques currents starting time investigated
novel hybrid nanostructures nanocomposites receiving increasing attention due newly evolved properties work alpha feo anchored graphene oxide nanosheet alpha feo synthesized facile hydrolysis process photo catalytic performances dtlrability heterogeneous fenton system fully evaluated decolorization rates methylene blue alpha feo system within wide range approximately fold classical degussa tio fold alpha feo enhanced decolorization methylene blue alpha feo system attributed unique incorporation catalyst mediated morphology active sites alpha feo nanoparticles also offered high electron conductivity electrostatic attraction negatively charged positively charged high efficiencies degradation achieved various surface charged organic pollutants around cationic compounds rhodamine rhb anionic compound orange oii orange neutral compounds phenol nitrophenol endocrine disrupting compound beta estradiol dominant reactive oxygen species ros responsible decolorization hydroxyl radicals circle superoxide anion radicals circle generated activation surface alpha feo detected quantified free radical quenching methods possible degradation mechanism involved rupture phenothiazine ring desulfurization rupture phenyl ring due attack ros analyzed reduction intermediates consistent decreasing trend acute toxicity towards luminous bacteria increasing irradiation time results lay foundation highly effective durable photo fenton technologies organic wastewater within wider ranges conventional photo fenton reaction elsevier rights reserved
addition anorexigenic properties neuroendocrine regulation hunger satiety mounting evidence indicates role nucb nesfatin regulation emotional stress responses seems occur sex specific way present study investigated association nucb nesfatin plasma levels anxiety depressiveness perceived stress obese men women alterations inpatient treatment expected decrease nucb nesfatin levels female increase male patients reporting relevant alleviation anxiety analyzed inpatients female male body mass index mean range mean age years hospitalized due morbid obesity mental necessarily anxiety disorders somatic comorbidities nucb nesfatin plasma levels measured elisa anxiety gad depressiveness phq perceived stress psq concurrently determined patient reported outcomes measurements carried initiation inpatient treatment clinically meaningful improvement anxiety achieved points gad missed point nucb nesfatin positively correlated anxiety scores women beginning inpatient treatment men significant negative correlation observed following treatment outset treatment trend observed unexpectedly neither women beginning treatment men improved anxiety scores displayed significant changes nucb nesfatin plasma levels although direction change expected decrease women increase men addition change nucb nesfatin explained course anxiety women men conclusion women men showed inverse association nucb nesfatin anxiety positive correlation women negative correlation men although correlation statistically significant men beginning treatment however significant change nucb nesfatin following improvement anxiety observed might due short observation interval due small anxiety improvements associated low baseline anxiety levels elsevier ltd rights reserved
use computers complex software pervasive archaeology yet role analytical pipeline rarely exposed researchers inspect reuse limits progress archaeology researchers easily reproduce work verify extend four general principles reproducible research emerged fields presented archaeological case study described shows principle implemented using freely available software costs benefits implementing reproducible research assessed primary benefit sharing data particular increased impact via increased number citations primary cost additional time required enhance reproducibility although exact amount difficult quantify
traditional power grid demand side management dsm techniques centralized mainly focus industrial consumers ignorance residential commercial sectors dsm activities degrades overall performance conventional grid therefore concept dsm demand response via residential sector makes smart grid superior traditional grid context paper proposes optimized home energy management system ohems facilitates integration renewable energy source res energy storage system ess also incorporates residential sector dsm activities proposed ohems minimizes electricity bill scheduling household appliances ess response dynamic pricing electricity market first constrained optimization problem mathematically formulated using multiple knapsack problems solved using heuristic algorithms genetic algorithm binary particle swarm optimization bpso wind driven optimization wdo bacterial foraging optimization bfo hybrid pso hgpo algorithms performance proposed scheme heuristic algorithms evaluated via matlab simulations results illustrate integration res ess reduces electricity bill peak average ratio par respectively moreover hgpo algorithm based home energy management system outperforms heuristic algorithms reduces bill par
paper describes method determining first two moments response basic components electrical circuits resistors inductors capacitors paper goal obtain closed form formulae moments describing voltage current stochastic processes assumed element parameters resistance inductance capacitance could random variables deterministic functions stochastic processes excitations second order stochastic processes moreover two cases dependence random parameters excitation stochastic processes considered obtained results enable determination exact solutions first two moments without application numerical algorithms
introduction hypothesis mixed urinary incontinence mui challenging condition manage describe protocol design rationale effects surgical treatment enhanced exercise mixed urinary incontinence esteem trial designed compare combined conservative surgical treatment approach versus surgery alone improving patient centered mui outcomes months methods esteem multisite prospective randomized trial female participants mui randomized standardized perioperative behavioral pelvic floor exercise intervention phis midurethral sling versus midurethral sling alone describe methods four challenges encountered design phase defusing study population selecting relevant patient centered outcomes determining sample size estimates using patient reported outcome measure designing analysis plan accommodates mui failure rates central theme design patient centeredness guided many key decisions primary outcome patient reported mui symptoms measured using urogenital distress inventory udi score months secondary outcomes include quality life sexual function cost effectiveness time failure need additional treatment results final study design implemented november across eight clinical sites pelvic floor disorders network february total targeted participants randomized conclusions describe esteem protocol methods reaching consensus methodological challenges designing trial mui maintaining patient perspective core key decisions trial provide information directly impact patient care clinical decision making
background sacral nerve stimulation sns surgical treatment fecal urinary incontinence consists inserting stimulating electrode one sacral holes addition benefit sns treatment incontinence recent studies showed sns effective treatment irritable bowel syndrome well bladder pain syndrome aim study evaluate effect sns visceral mechanosensitivity cross organ sensitization rat model methods hypersensitive model obtained instillation acetic acid bladder rats minutes minutes start experiments visceral sensitivity assessed monitoring change mean arterial pressure response graded isobaric colorectal distension series decipher mechanisms underlying sns effect rats administered intravenously either nonselective opioid receptor antagonist naloxone nitric oxide synthesis antagonist name neuronal activation dorsal horn sacral spinal cord measured counting fos immunoreactive cells response colorectal distension nms key results intravesical acetic acid instillation increased mean arterial pressure variation response colorectal distension compared saline group sns reduced variation arterial pressure colorectal distension induced rise fos immunoreactive cells dorsal horn spinal cord effect reduced sns conclusions inferences sns reduces visceral mechanosensitivity cross organ sensitization model
muscle injuries lower limb common among professional football players classification made according severity diagnosed radiological assessment grade minor strain minor injury grade partial rupture moderate injury grade iii complete rupture severe injury tetrapolar localized bioimpedance analysis bia khz made phase sensitive analyzer used assess damage integrity muscle structures fluid accumulation injury injuries quadriceps hamstring calf diagnosed magnetic resonance imaging mri aim study identify pattern change bia variables indicators fluid resistance cell structure integrity reactance phase angle according severity mri defined injury difference compared non injured contralateral muscle also measured injury respectively grade grade grade iii showing greater significant decrease greatest relative changes grade iii injuries however decreases indicate fluid distribution proportional severity injury disruption muscle structure demonstrated localized determination increased severity muscle injury significant changes injury sizeable decrease indicates pattern disrupted soft tissue structure proportional severity injury
chrysophanol extracted plants rheum genus possesses various pharmacological effects including anti inflammatory activity purpose present study evaluate protective effects underlying mechanisms ovalbumin ova induced asthma mice fifty mice randomly assigned five experimental groups control group model group dexamethasone group groups number eosinophil cells production interleukin beta tumor necrosis factor alpha bronchoalveolar lavage fluid balf measured addition pulmonary histopathology airway resistance raw helper cells frequency ror gamma expression evaluated study demonstrated effectively decreased eosinophil count inflammatory cytokines production balf addition treatment significantly inhibited raw percentage ror gamma expression ova induced animals compared model group histological studies also demonstrated significantly suppressed ova induced eosinophilia lung tissue compared model group findings supported prevent allergic asthma mouse model
quercetin polyphenolic flavonoid found many plants used nutritional supplement reported biological properties may play important role prevention human diseases cancer cardiovascular diseases diabetes ulcer cataract allergies research solidified floating organic drop microextraction coupled high performance liquid chromatography used extract determine quercetin rosa canina growing different areas lorestan province iran effect important experimental variables type volume extracting organic solvent extraction temperature time effect ionic strength extraction recovery investigated optimized optimum extraction conditions linear response obtained range relative standard deviation rsd enrichment factor found respectively proposed method applied successfully determination quercetin calycles fruit canina samples results showed good agreement compared obtained validated standard method
arbitrary fractional order integrator designed method constructing rational approximation function form continued product paper takes half order integrator example exhibit design process circuit made level active operational amplifier network size equal order rational function since rational approximation function form continued product consists several first order damp elements first derivative elements greatly simplify design process fractional integrator needs four different resistors series regular capacitors thanks properties fractional integrator easily manufactured industrial production commercial purpose shows designed fractional integrator based proposed method rational performance simulations comparison methods test multisim
transportation sector responsible greenhouse gas emissions united states implying plays important role achieving sustainability goals slowing impact climate change understand influence road roughness vehicle fuel consumption researchers recently proposed stochastic pavement models combined mechanics based vehicle model study energy dissipated vehicle suspension solutions obtained frequency domain computational effort increases rapidly complicated vehicle types surface profiles considered paper proposes new formulation solution procedure estimating energy dissipation tire suspension vehicles traversing rough nondeformable pavements herein filtered white noise model road roughness combined quarter car model vehicle yield augmented state space representation lyapunov equation governing covariance responses solved obtain energy dissipation vehicle subsequently examples provided illustrate efficacy flexibility proposed approach american society civil engineers
many resource allocation problems formulated constrained maximization utility function network utility maximization num applies optimization techniques achieve decomposition duality primal dual method several important problems example joint source rate control routing scheduling design optimized using framework work introduce important network security concept trust num formulation integrate nodes trust values optimization framework trust values based interaction history network entities community based monitoring objective avoid routing packets though paths large percentage malicious nodes also add end end delay constraints traffic flows delay constraints introduced capture imposed quality service qos requirements traffic flow
evaluate efficacy golimumab severe frequent recurrent anterior uveitis patients hla positive ankylosing spondylitis study eyes hla positive patients resistant anterior uveitis received subcutaneous golimumab gol per month due frequent uveitis recurrences analyzed retrospectively may october assessment criteria uveitis activity number recurrence uveitis visual acuity systemic corticosteroid drug requirement maintenance remission twelve patients eyes hla positive ankylosing spondylitis anterior uveitis treated golimumab month remission uveitis observed eyes malign hypertension developed one subject second dose golimumab therefore treatment stopped subject excluded study median follow time months interquartile range uveitic reaction seen except patient stopped treatment topical systemic steroid necessity needed except two cases oral systemic maintenance visual acuity significantly increased golimumab may new effective choice maintaining remission prevention recurrences severe resistant anterior uveitis patients hla positive ankylosing spondylitis
linux operating system los sophisticated man made system one ubiquitous operating systems however little research structure functionality evolution los prospective networks paper investigate evolution los network major releases los ranging versions modeled directed networks functions denoted nodes function calls denoted edges found size los network grows almost linearly clustering coefficient monotonically decays degree distributions almost degree follows exponential distribution degree undirected degree follow power law distributions explore functionality evolution los network observed evolution functional modules shown sequence seven events changes succeeding including continuing growth contraction birth splitting death merging events means statistical analysis events top largest components arch drivers net shown continuing growth contraction events occupy events work exemplifies better understanding describing dynamics los evolution elsevier rights reserved
combat related posttraumatic stress disorder ptsd common among returning veterans serious debilitating disorder highly effective treatments involving trauma exposure exist difficulties engagement early drop may lead sub optimal outcomes mindfulness training may provide method increasing emotional regulation skills may improve engagement trauma focused therapy examine potential neural correlates mindfulness training vivo exposure non trauma focused using novel group therapy mindfulness based exposure therapy mbet afghanistan iraq oif combat veterans ptsd oif combat veterans ptsd treated mbet comparison group therapy present centered group therapy pcgt ptsd symptoms assessed pre post therapy clinician administered ptsd scale functional neuroimaging fmri therapy examined responses emotional faces angry fearful neutral faces patients treated mbet reduced ptsd symptoms effect size effect significantly different pcgt improvement ptsd symptoms pre post treatment treatment groups correlated increased activity rostral anterior cingulate cortex dorsal medial prefrontal cortex mpfc left amygdala mbet group showed greater increases amygdala fusiform gyrus responses angry faces well increased response left mpfc fearful faces preliminary findings provide intriguing evidence mbet group therapy ptsd may lead changes neural processing social emotional threat related symptom reduction
intensive economic shipping activities singapore strait caused singapore coastal waters high risk water pollution nested three dimensional unstructured grid suntans model applied singapore coastal waters simulate flow pollutant transport small domain similar resolution singapore coastal model nested within large domain similar resolution regional model nested model able predict water surface elevations velocities high values respectively model results delineate characteristics circulation pattern singapore coastal waters northeast southwest monsoons pollutants modeled passive tracers released six key sailing locations points singapore coastal waters named passive tracers respectively results show rate dispersionis twice large northeast monsoon compared southwest monsoon due differences large scale monsoons small scale local winds volume averaged concentration vac diminishes faster local flushing time shorter northeast monsoon southwest monsoon dispersion coefficients vac decreasing rate maximum tracers shortest local flushing time due strong surrounding currents abrupt bathymetry changes near senang john islands dispersion coefficients vac decreasing rate minimum tracer due weak currents induced semi enclosed coastline near tuas found lateral dispersion coefficient compound dispersion coefficient obey law defines linear correlation dispersion coefficients power selected length scale elsevier ltd rights reserved
objective one quit attempt varenicline found cost effective smoking cessation intervention purpose study analyze varenicline cost effectiveness patients relapse first treatment comparison made treatment schema varenicline treatment schema bupropion nrt unaided cessation treatment varenicline finnish context methods two quit version benesco markov model used follow cohort smokers making two quit attempts lifetime abstinence rates interventions derived cochrane review gender age specific data incidence prevalence five smoking related diseases included model quality adjusted life years total expected costs lifetime cumulative incidence smoking related morbidities mortality primary outcomes evaluated results study cohort comprised smokers willing make quit attempt lifetime simulation treatment varenicline yielded extra quitters depending comparator among quitters possible prevent additional cases smoking related diseases deaths attributable smoking treatment varenicline resulted cost savings million euros treatment varenicline dominated smoking cessation interventions used analysis sensitivity analysis supported robustness base case results limitations analysis consider adverse events included five major smoking related diseases conservative approach probably leads estimation cost effectiveness cessation interventions furthermore assumptions constant relative risks smoking related diseases smoking status proxy values used efficacy estimates second quit attempts interventions varenicline limitations conclusions second quitting effort varenicline economically justifiable
demonstrate pressure sensor matrix weight distribution feet influenced body posture small cheap carpet equipped low precision pressure sensor matrix already sufficient detect subtle activities identity person carpet matrix bit pressure sensors achieve accuracy test subjects performing subtle activities open different drawers cabinet doors accuracy recognizing performed activities thus see potential using single carpet unified approach houses detect inhabitants interact furniture without attaching different sensors onto single furniture
apicomplexan parasite sarcocystis neurona causes equine protozoal myeloencephalitis epm degenerative neurological disease horses due host range expansion neurona emerging threat requires close monitoring apicomplexans protein kinases pks implicated myriad critical functions host cell invasion cell cycle progression host immune response evasion used various bioinformatics methods define kinome neurona phylogenetic relatedness pks apicomplexans identified putative pks clustering within various eukaryotic kinase groups although containing universally conserved pka agc group neurona kinome devoid pkb pkc moreover kinome contains six conserved apicomplexan cdpks camk group several opk atypical kinases including ropks identified notably neurona devoid virulence associated ropks well alpha rio kinases two three neurona enzymes high sequence similarities toxoplasma gondii tgck tgck plasmodium pfck experimental studies neurona putative pks identified study required validate functional roles pks understand involvement mechanisms regulate various cellular processes host parasite interactions given essentiality apicomplexan pks survival apicomplexans current study offers platform future development novel therapeutics epm instance via application inhibitors block parasite invasion development host
unique depth scientific knowledge allowed physical metallurgy lead development successful computational materials design methodology grounded system fundamental databases expansion approach embrace acceleration full development qualification cycle resulted first fully computationally designed qualified material reaching flight stage example high performance alloys provides template general methodology computational design materials acta materialia inc published elsevier ltd rights reserved
flood hazard modeling important task decision making flood management aiming preventing human material losses therefore pressing need reliable predictive tools order identify flood prone areas recently increase cheap computational power studies context use one two dimensional deterministic hydraulic models provide estimates flood extent depth satisfactory accuracy reduced time models however capture relatively small fraction active processes simulating flood without consideration morphological change hydro morphodynamic solutions realistic considering influences channel floodplain morphologies simulate inundation flow research seeks assess suitability landscape evolution model lem simulate adequately hydraulics flood events real case scenario opted use model cellular automaton evolutionary slope river caesar originally lem recently undergone real evolution integrating hydrodynamic flow routing algorithm lisflood caesar lisflood caesar reduced complexity depth integrated storage cell model simulates flow sediment transport response hydrological inputs area urban reach river bouregreg morocco large swampy floodplain complex topography performance reduced complexity model caesar flood mapping investigated benchmarked one dimensional hydraulic model hydrologic engineering center river analysis system hec ras combined climate hydrologic modeling used generate input flow data hydraulic models results approaches agree well show relative good consistency estimating flood extent magnitude differences occur easily explained result unavoidable differences concepts implementation
background oxygen recommended treatment acute cluster headache attacks however available worldwide methods international headache society performed survey among national member societies availability restrictions oxygen treatment cluster headache results oxygen reimbursed countries responding additional restrictions reimbursement facial mask respect age conclusion oxygen treatment cluster headache attack reimbursed worldwide headache societies pressure national public health authorities reimburse oxygen cluster headache countries
background intravenous infusion pituitary adenylate cyclase activating polypeptide pacap provokes migraine attacks migraine without aura patients investigated whether pacap infusion causes changes endogenous production pacap vasoactive intestinal polypeptide vip calcitonin gene related peptide cgrp tumour necrosis factor alpha tnf alpha calcium binding protein neuron specific enolase pituitary hormones migraine patients methods allocated previously genotyped patients receive intravenous infusion pacap pmol minute minutes recorded migraine like attacks sixteen patients carriers risk allele mefd confers increased risk may regulate pacap expression non carriers collected blood samples baseline minutes start infusion control group six healthy volunteers received intravenous saline results pacap infusion caused significant changes plasma concentrations vip prolactin difference changes biochemical variables patients without mefd associated gene variant conclusion pacap infusion elevated plasma levels vip prolactin tsh cgrp tnf alpha development delayed migraine like attacks presence mefd gene variant associated preictal changes plasma levels neuropeptides tnf alpha pituitary hormones
despite advantages promising features ionic polymer metal composite ipmc smart material drawbacks eliminated much possible improving ipmc performance one important drawbacks back relaxation step input voltage applied ipmc bends toward anode unwanted slow bending ipmc back toward cathode several techniques based using feedback control loop proposed eliminating effect however techniques effective bending displacement ipmc small paper propose nonfeedback method restraining ipmc effect even large bending displacement proposed technique based fast reciprocating motions free water molecules nafion membrane anode cathode purpose used local gaussian disturbance specifically patterned ipmc described idea conceptually validated several experimental results
attempt made first part paper review history reactor safety draw conclusions trends could avoided directions could lead robust reactor designs would susceptible severe accidents second part progress reactor thermal hydraulics observed reviewing list conference sessions finally report made recent work two computational problems prediction departure nucleate boiling potential spatial coupling computational multifluid dynamics methods achieve multiscale high resolution simulations
group projects help students develop certain generic skills sought employers current paper presents results peer reviews lecturer assessments professionalism engineering built environment course involved first year students department mechanical materials engineering sessions aforementioned tools used measure performance student current study aims determine individual weaknesses strengths group relate group performance based individual presentation mark also studies relationship two tools findings show peer review lecturer assessment used tools determining performance students team relationship two tools small published elsevier ltd selection peer reviewed responsibility ukm teaching learning congress
fusarium oxysporum melonis snyd hans race fom virulent yield limiting pathogen melon cucumis melo worldwide current information suggest resistance race controlled multiple recessive genes strongly affected environment rna seq analysis used identify candidate resistance genes dissect early molecular processes deployed melon fom interaction resistant doubled haploid line nad susceptible genotype charentais cht post inoculation hpi transcriptome analysis nad fom interaction identified differentially expressed genes degs hpi hpi respectively susceptible combination cht fom degs recovered hpi hpi respectively overall expression profile suggests prompt activation defense responses nad due basal defense related machinery allows early pathogen recognition gene ontology enrichment analyses revealed total terms shared genotypes consistent response fungal infection classes named chitinase activity cellulase activity defense response incompatible interaction auxin polar transport emerged major factors resistance fom data indicated nad reacts fom fine regulation mediated signaling pathways cell wall reorganization hormone crosstalk jasmonate ethylene auxin abscissic acid several unannotated transcripts recovered providing basis exploration melon resistance genes degs belonging fom genome also detected planta resource identification potential pathogenicity factors work provides broader view dynamic changes melon transcriptome triggered fom highlights resistance response nad mainly signaled jasmonic acid ethylene pathways mediated aba auxin role candidate plant fungal responsive genes involved resistance discussed
mapping relational data linked data rdbrdf essential prerequisite evolving world wide web web data propose methodology evaluate quality mappings set objective metrics methodology whose key principles approved survey among rdbrdf experts applied evaluate automatically manually performed mappings regardless representation main contributions paper assessing quality requirements mappings relational databases rdf proposing methods measuring well given mapping meets requirements showcase usage individual metrics illustrative examples real life application additionally provide guidelines improve given mapping regard specific metrics
internet things iot makes smart objects ultimate building blocks development cyber physical smart pervasive frameworks iot variety application domains including health care iot revolution redesigning modern health care promising technological economic social prospects paper surveys advances iot based health care technologies reviews state art network architectures platforms applications industrial trends iot based health care solutions addition paper analyzes distinct iot security privacy features including security requirements threat models attack taxonomies health care perspective paper proposes intelligent collaborative security model minimize security risk discusses different innovations big data ambient intelligence wearables leveraged health care context addresses various iot ehealth policies regulations across world determine facilitate economies societies terms sustainable development provides avenues future research iot based health care based set open issues challenges
recent work baez fong author introduced framework describing markov processes equipped detailed balanced equilibrium open systems certain type open markov processes serve building blocks complicated processes paper describe potential application framework modeling biological systems open systems maintained away equilibrium show non equilibrium steady states emerge open systems type even rates underlying process detailed balanced equilibrium permitted shown non equilibrium steady states minimize quadratic form call dissipation circumstances dissipation approximately equal rate change relative entropy plus correction term hand prigogine principle minimum entropy production generally fails non equilibrium steady states use simple model membrane transport illustrate concepts
people commonly question whether highly psychopathic offenders treatable little scientific research addressed question despite key developments last years two relevant areas reliable measurement psychopathy effective treatments reducing criminal antisocial behavior offenders one obstacle progress confusion defining psychopathy necessary preliminary step advancing intervention outlining principal definitional issues review past recent research psychopathy treatment concluding handful newer well designed studies suggest grounds optimism psychopathy treatability although psychopathy characteristics along indices criminal risk signal responsivity challenges well conceived programs higher risk offenders reduce recidivism highly psychopathic offenders appear reducing dynamic risk factors clear indications yet whether pcl psychopathic offenders differ high risk offenders ability respond treatments questions whether psychopathy responds treatment forms treatment might take yet addressed conclude suggesting advances come use divergent measures psychopathy particular dynamic measures psychopathy traits allow document whether change occurring elsevier ltd rights reserved
present study aimed verify body weight could influence self perception terms body image mood states dissatisfaction physical appearance risk eating disorders particular evaluated differences women normal weight overweight obese delicate phase puerperium verify different emotional structures linked bmi thirty two women normal weight overweight obese belonging department obstetrics gynaecology university hospital individually interviewed body uneasiness test eating disorder inventory edi profile mood states poms used evaluation findings showed bmi puerperium significantly correlated mood states body perception furthermore significant differences emerged eating attitudes behaviours specific aspects related weight gain phobia body shape perception symptoms classically associated risk developing eating disorder
memory reactivation activation latent memory trace reminded past experience strengthens memory also contribute distortions new information present reactivation integrated existing memory previous study young adults found quality memory reactivation manipulated using principle encoding specificity indexed recollection ratings modulated subsequent true false memories events experienced museum tour study examined age related changes quality memory reactivation subsequent memory memories museum stops young older adults reactivated immediately followed presentation novel lure photo alternate tour version reactivation plus new information increase subsequent true memories reactivated targets subsequent false memories lures followed reactivated targets compared baseline target lure photos however influence reactivation subsequent memories reduced older adults data reveal ageing alters reactivation related updating processes allow memories strengthened updated new information consequently reducing memory distortions older adults compared young adults
purpose review social media great impact aspects life throughout world utilization social media occupational lung disease however much limited article summarizes recent literature concerning social media occupational lung disease identifies areas additional use recent findings social media used six relevant areas information dissemination peer peer communication survey research data collection participatory research exposome data acquisition assessing public concerns knowledge generation clear advantages information dissemination experts workers peer peer basis although variable credibility accuracy concerns persist research social media used acquiring data posted nonresearch purposes efficiently collecting information specifically research benefits efficiency democracy large data sources may counterbalance concerns inadequate specification recruitment strategies limited control data quality summary potential benefits using social media lung health workplace interactions much greater limited current utilization
background aim since skin moisturization may achieved actives chosen carrier plant stem cells squalene natural alkyl polyglucoside emulsifier may potential components contemporary cosmetic products aim study vivo evaluation skin irritation potential efficacy alpine rose stem cells incorporated liposomes olive oil squalene ingredients moisturizing creams respect novel emulsifier used creams stabilization methods employment noninvasive skin biophysical measurements skin hydration transepidermal water loss tewl erythema index viscoelasticity measured healthy volunteers first phase skin irritation hour occlusion long term efficacy creams day study healthy skin evaluated phase study focused cream efficacy assessment day treatment sodium lauryl sulfate irritated skin results hour occlusion significant changes tested sample second phase study significantly altered cream containing squalene application active samples resulted significant reduction tewl phases study increase recorded especially squalene containing cream conclusion due lack skin irritation skin barrier impairment along marked hydration effect could said investigated actives incorporated alkyl polyglucoside emulsifier stabilized creams may safely applied ingredients tailor made cosmetic moisturizers intended normal dry skin care whereas olive oil squalene could used treatment irritated sensitive skin well
activated pik delta syndrome refers recently described primary immunodeficiency syndrome consisting recurrent sinopulmonary infections lymphadenopathy mucosal lymphoid aggregates increased susceptibility epstein barr virus cytomegalovirus increased incidence cell lymphomas variants pikcd encodes phosphatidylinositol bisphosphate kinase catalytic subunit delta isoform enhance membrane association kinase activity resulting increased signal transduction pik akt pathway whole exome sequencing revealed pathogenic pikcd variant patient history immunologic impairment recurrent sinopulmonary infections lymphoid hyperplasia presenting intussusception case illustrates lymphoid hyperplasia secondary immunodeficiency often unsurprising non threatening present emergency like intussusception
innovative highly efficient random vibration series algorithms pseudo excitation method pem effective applications bridge dynamics presented pem transforms stationary random vibration equations simple harmonic vibration equations transforms non stationary random vibration equations ordinary equations motion structures subjected deterministic time history loading therefore solution processes considerably simplified also computational effort greatly reduced numerical results remain highly accurate method widely used chinese engineering community adopted recommended chinese official guidelines seismic design highway bridges also described detail vibration shock handbook crc press bridge engineering handbook crc press means pem flutter buffet cqc based analysis successfully performed main span xihoumen bridge second longest suspension bridge world located well known typhoon region zhou islands east china sea addition pem also become widely used research design tool vehicle engineering china including vehicle bridge dynamic interaction problems finite element model power spectral analysis high speed train coach degrees freedom presented along brief introduction pem presentation also show number practical engineering examples successfully used pem related research design
photovoltaic arrays means convert solar power electricity significant way generate renewable clean energy efficient photovoltaic must generate constantly maximum possible power different environmental conditions finding maximum generated power known issue industry using methods classic control theory good results however solutions case specific resulting increased set effort work proposes universal rlmppt control method based reinforcement learning method tracks adjusts maximum power point photovoltaic source without prior knowledge markov decision process mdp model maximum power point tracking mppt photovoltaic process defined algorithm proposed evaluated number photovoltaic sources proposed rlmppt control method advantage applicable different sources minimum set time evaluate rlmppt control method performance number simulations run different environmental operating conditions comparison conventional method perturb observe performed results show quick response close optimal behavior without requiring prior knowledge elsevier ltd rights reserved
objectives acquired immunodeficiency syndrome aids disease human immune system caused human immunodeficiency virus hiv people aids much vulnerable infections including opportunistic infections tumors people healthy immune system objective study correlate oral lesions associated hiv aids immunosuppression levels measuring clusters differentiation cell counts among patients living middle western regions ghana materials methods total patients visited hiv clinic komfo anokye teaching hospital regional hospital sunyani ghana consecutively enrolled prospective cross sectional study referred patients baseline counts obtained medical records patient received initial physician assessment intraoral diagnoses based classification diagnostic criteria eec clearinghouse initial assessment extra intraoral tissues enrolled patient examined data analyses carried using simple proportions frequencies chi square tests significance results study included patients comprised males females ranging age years sex specific mean ages years males years females patient count values ranged cells mean baseline count cells males cells females mean baseline count entire sample cells patients examined observed least one hiv associated intraoral lesion intraoral lesions oral candidiasis periodontitis melanotic hyperpigmentation gingivitis xerostomia common oral lesions conclusion total nine oral lesions six lesions included oral candidiasis periodontitis melanotic hyperpigmentation gingivitis xerostomia oral hairy leukoplakia significantly correlated declining counts
ingaas variant appears promising channel material high performance low power scaled cmos applications due excellent carrier transport properties however mos transistors made suffer poor electrostatic integrity work consider underlap ultra thin body utb inas insulator channel mos transistor study effect varying gate source drain underlap length analog performance device help technology computer aided design tcad simulation calibrated schrodinger poisson solver experimental results underlap technique improves gate electrostatic integrity turn improves analog performance develop non quasi static nqs small signal equivalent circuit model device used study performance increase underlap length unity gain cut frequency degrades maximum oscillation frequency improves beyond certain value underlap length study gain frequency response common source amplifier using nqs model spice simulation observe voltage gain gain bandwidth improves elsevier ltd rights reserved
enormous genetic plasticity malaria parasite challenges developing potential malaria vaccine candidate highest efficacy still remain study incorporated bioinformatics based screening approach explore potential vaccine candidates plasmodium falciparum proteome systematic strategy defined screen proteins malaria parasite metabolic pathways mpmp database basis surface exposure non homology host proteome orthology related plasmodium species mhc class binding promiscuity approach reported pfd putative metabolite transporter protein novel vaccine candidate raptorx server used generate model protein validated procheck furthermore predicted cell cell epitopes highest score subjected energy minimization molecular dynamics simulation examine stability within solvent system results study could facilitate selection proteins entry vaccine production pipeline future
nuclear energy considered important part long term energy mixture china accompanying development nuclear power program extensive research development activities initiated nuclear thermal hydraulics recognized key subject development nuclear technology target nuclear thermal hydraulics remove heat safely fuel thermal hydraulics activities china cover three main areas namely reactor core thermal hydraulics safety related thermal hydraulics fundamental thermal hydraulics paper gives brief summary ongoing activities three areas focus selected topics transversal mixing nonuniform heat transfer distribution fuel assemblies two phase distribution external reactor vessel cooling conditions heat transfer supercritical fluids state art ongoing works challenging aspects presented discussed
work ultrasound based measurement method used monitoring suspension velocity build magnetic material inside wet low intensity magnetic separator process used beneficiation magnetite ores today available option monitor material transport unit operations flow rate solids concentration particle size distribution suspension flow pipes measured online using standard equipment acoustic backscatter system fitted tank separator used monitor internal flow method called ultrasonic velocity profiling used capture internal velocity profiles simultaneously backscatter signal intensity used get indications local solids concentration flow build magnetic material methods evaluated realistic conditions effect varying factors relevant machine performance investigated included factors slurry feed rate slurry solids concentration magnet assembly angle drum rotational speed presented method gives useful information internal material flow inside separator velocity measurements capture sometimes complex internal flow patterns example presence velocity recirculating flow dewatering zone additionally keeping balanced material loading concentrate dewatering zone important separator performance using signal backscatter intensity possible qualitatively monitor material loading generally direct measurements aid improvements machine design process optimization process control elsevier ltd rights reserved
flow viscous fluid cochlea induces shear forces could provide benefit clinical practice example guide cochlear implant insertion produce static pressure cochlear partition wall research standpoint studying effects viscous fluid cochlea provides data better understanding cochlear fluid mechanics however cochlear perfusion viscous fluid may damage cochlea work studied physiological anatomical effects perfusing cochlea viscous fluid gerbil cochleae perfused rate min artificial perilymph sodium hyaluronate healon four different concentrations different concentrations applied either sequentially cochlea individually different cochleae perfusion fluid entered round window withdrawn basal scala vestibuli order perfuse entire perilymphatic space compound action potentials cap measured perfusion perfusion increasing concentrations order increasing viscosity cap thresholds generally increased threshold elevation perfusion small almost zero borderline case higher concentrations significantly elevated cap thresholds histology cochleae perfused showed intact reissner membrane cochleae perfused torn thus cap threshold elevation likely due broken likely caused shear stress produced flow viscous fluid results analysis indicate cochlea sustain without significant cap threshold shift shear stress beside finding perfusion cases temporary cap threshold shift observed perhaps due presence clearance viscous fluid within cochlea temporary position shift organ corti perfusion short latency positive peak appeared cap waveform might due change cochlea traveling wave pattern distortion cochlear microphonic elsevier rights reserved
background treating patients experience residual psychotic symptoms remission schizophrenia remains one challenging problems mechanisms underlying symptoms differ acute hallucinations delusions receptor antagonists considered promising agents treatment residual psychotic symptoms cognitive dysfunction aim study assess efficacy selective inhibitor avisetron reduction residual psychotic symptoms patients schizophrenia stable antipsychotic therapy methods eighty clinically stable outpatient subjects schizophrenia residual psychotic symptoms randomized double blind manner weeks avisetron placebo ratio subjects received avisetron placebo top stable antipsychotic treatment standard clinical scales cognitive tests used endpoint assessment primary efficacy endpoint mean reduction total positive negative syndrome scale score weeks treatment results significant differences primary secondary endpoints found groups however based subgroup analysis significant improvement total positive negative syndrome scale score residual psychotic symptoms observed female patients conclusions negative study unexpected benefits drug females hypothesized role patients sex impact treatment response serotonergic drugs general suggest possible synergistic interaction estrogen avisetron means modulating effect estrogens serotonergic system future studies targeting sex related effects serotonergic drugs warranted
relationship customers suppliers remains challenge agile software development two trends seek improve relationship increased focus value move towards continuous deployment special section continuous value delivery describe emerging research themes show increasing interest topics time discuss implications future research authors published elsevier
newborns infants highly depending successfully communicating needs crying facial expressions although growing interest mechanisms possible influences recognition facial expressions infants heretofore exists validated database emotional infant faces present article introduce standardized freely available face database containing caucasian infant face images infants months old development validation tromso infant faces tif database presented study adults categorized photographs seven emotion categories happy sad disgusted angry afraid surprised neutral rated intensity clarity valance order examine relevance tif present first application study investigating differences emotion recognition across different stages parenthood found small gender effect terms women giving higher intensity clarity ratings men moreover parents young children rated images clearer groups parents rated neutral expressions clearly intense results suggest caretaking experience provides implicit advantage processing emotional expressions infant faces especially difficult ambiguous expressions
background high percentage biventricular biv left ventricular pacing cardiac resynchronization therapy crt devices associated superior clinical outcomes however percent ventricular pacing reported crt devices simply indicates number paces device delivered proportion pacing captured effectively objective purpose study determine whether beat beat evaluation effective pacing would provide accurate evaluation crt delivery methods automatic electrogram egm based algorithm classifies pace effective ineffective based detection morphology unipolar egm pacing developed validated egms recorded hour hotter crt patients postprocessed percent effective crt crt pacing calculated dividing time spent crt pacing total time recording results crt cohort average pacing significantly overestimated crt pacing significant minority subjects discrepancy least percentage points pacing crt pacing mean conclusion current device pacing diagnostics overestimate amount crt pacing actually delivered new algorithm quantifies ineffective crt pacing enables clinicians identify patients issue address reasons behind suboptimal crt delivery
purpose research indicates family therapy courses gender studies affect female male students degree female students experience gender focused family therapy class yet explored qualitative study focused self identified cis female students experiences ten week course gender family therapy purpose study present female students critical reflections taking clinical training course dedicated gender studies method using transcendental phenomenology analysed reflections student participants regarding perceived gendered new information transformed thoughts actions thematic analysis data inductive read reread reflections generated several main themes results participants challenged revisit gendered assumptions significant insignificant concerns development organized women self reports four domains affect identity empowerment action conclusions summary addressing gender related topics classroom impacted students intra personally interpersonally processed internally began reshape relationships additionally planned become agents change therapy room practitioner points therapists recognize gender related power differences gender roles societal familial systems ways unequal gender relations affect relationships therapists address position women cultures also social environment reproduces positioning within ranks educators ensure pedagogies therapeutic practices constantly reflect gender aware practices order culturally competent
background irritant sodium lauryl sulfate sls known cause decrease stratum corneum level natural moisturizing factor nmf associated changes corneocyte surface topography objective explore phenomenon allergic contact dermatitis methods patch testing performed patients previously positive patch test reactions potassium dichromate nickel sulfate methylchloroisothiazolinone mci methylisothiazolinone phenylenediamine moreover control pet patch irritant sls patch applied days stratum corneum tested sites collected nmf levels corneocyte morphology expressed amount circular nanosize objects quantified according dermal texture index dti determined results among allergens mci reduced nmf levels significantly sls furthermore mci caused remarkable changes microscopic level corneocytes hexagonal shaped pronounced cell borders smoother surface dti increased sls exposure allergen exposure conclusions mci significantly decreased nmf levels similarly sls altered corneocyte morphology suggests skin barrier damage plays role pathogenesis mci contact allergy dti seems differentiate reactions sls allergens tested sls agent caused dti increase
roughly past ten years working creating using virtual remote laboratories science engineering education providing number software tools facilitate creation virtual laboratories simulations used promote active role students studying certain phenomena remote laboratories add extra value using real hardware typically distant location shows students additional issues appear using real equipment pedagogical benefits particularly effective laboratories designed used using interactive engagement approach work received gift collaboration many people interested improving education particular physics control engineering taught features software platforms required create virtual remote laboratories review lessons learned past ten years successful outcomes apply lessons prepare integration computers tablets mobile devices platform independent cloud based computing laboratories ifac international federation automatic control hosting elsevier ltd rights reserved
golden mussel limnoperna fortunei filter collector macroinvertebrate species originating southern china easily invades water transfer tunnels attaches onto tunnel walls structures extremely high density resulting biofouling pipe clogging structure corrosion decrease water transfer efficiency water pollution become prevalent problem caused concern world however effective environment friendly method controlling golden mussel invasion yet approved study aimed propose measures preventing golden mussel invasion biofouling water transfer tunnels east river water source project erwsp transfers water east river shenzhen southern china million people long term samplings observations east river water performed study golden mussel invading pattern flume experiments done study golden mussel attachment different materials performance turbulent flows integrated ecological prevention pool designed constructed based flume experimental results preventing golden mussel invasion scale model tunnels erwsp major technology ecological pool preventing golden mussel entering tunnels attracting veligers attach geotextile cloth attracting mussels attach bamboo killing veligers high frequency turbulence eight month application experiment showed ecological pool successfully controlled golden mussel invasion biofouling scale model tunnels mussel density attachment materials decreased sharply distance materials pool entrance increased turbulence effective killing veligers escaped attachment materials mussel found model tunnels thus integrated ecological prevention pool recommended successful measure controlling golden mussel invasion biofouling water transfer tunnels international association hydro environment engineering research asia pacific division published elsevier rights reserved
background several immune mediated inflammatory disorders rheumatoid arthritis psoriatic arthritis systemic lupus erythematosus linked increased risk venous thromboembolism vte however data ankylosing spondylitis limited methods conducted systematic review meta analysis observational studies reported odds ratio relative risk hazard ratio standardized incidence ratio comparing risk vte possible pulmonary embolism patients versus non participants pooled risk ratio confidence intervals calculated using random effect generic inverse variance method dersimonian laird results potentially relevant articles three studies met inclusion criteria thus included data analysis pooled risk ratio vte patients confidence interval statistical heterogeneity study high conclusion study demonstrated statistically significant increased vte risk among patients
upper digestive tract routinely scoped several causes malabsorption number duodenal biopsy specimens increased notably last years gluten sensitive enteropathy gse autoimmune disease shows increasing prevalence worldwide requires joint clinico pathological approach classical histopathology gse partial total villous blunting well recognized classification gse straightforward moreover several mimickers gse intraepithelial lymphocytosis identified last years drug interactions medical comorbidities adding conundrum review report normal duodenal mucosa clinical presentation laboratory diagnosis gse duodenal intraepithelial lymphocytes immunophenotype gse associated lymphocytes gse mimickers differences across oceans among guidelines diagnosing gse use synoptic report reporting duodenal biopsies children adults century
study thermodynamics cloud point two non ionic surfactants polyoxyethylene iso octylphenyl ether polyoxyethylene lauryl ether brij investigated different electrolyte concentrations measurements cloud point temperatures visible spectrophotometer used instead visual observation liso naso kno kso kpo used electrolytes thermodynamic parameters calculated cloud point values nonionic surfactant electrolyte mixtures values presence kno obtained extrapolation straight line results energetics clouding showed standard gibbs free energy triangle positive enthalpy triangle entropy triangle negative cases furthermore enthalpy entropy compensation relationship estimated compensation temperature values values found brij respectively published elsevier
causal attributions social events crucial understanding emotional responses aim study identify appraisal processes response social exclusion borderline personality disorder bpd social anxiety disorder sad twenty five patients bpd patients sad healthy controls played cyberball virtual ball tossing paradigm experimentally induces social exclusion causal attributions subjective feelings action tendencies response social exclusion assessed clinical groups showed internal attributions less control attributions control group reported higher increase self focused negative emotions along escape tendencies less intent engage pleasant activities bpd group reported higher hostile intent attributions aggressive action tendencies compared healthy controls elsevier ltd rights reserved
many identity based proxy signature ibps schemes proposed proved secure using random oracle model attracted considerable criticism cao cao proposed ibps scheme using standard model scheme shown insecure could resist delegator attack order overcome weakness proposed new ibps scheme uses standard model also provided detailed security model ibps however study demonstrate scheme still vulnerable delegator attack order correct problem propose improvement ibps scheme described also present efficiency analysis scheme detailed security proof based computational diffie hellman assumption
entire himalayan region prone disasters many people vulnerable hydroclimatic threats extreme rainfall driven floods glacial lake outburst floods glofs landslide lake outburst floods llofs landslides triggered rainfall landslides floods related former cause lakes burst floods undercut slopes cause landslides past years landslides floods caused llofs garhwal himalaya occurred disastrous event terms loss life economic impact occurred june result extreme rainfall higher himalaya breaching moraine dammed lake short lived llofs rainfall induced runoff landslides outmigration area result event caused anxiety future economy also concerns security state international border contribution planning reconstruction secure livelihoods local people entice migrants return paper identifies zones mandakini valley susceptible landslides using weights evidence approach roles climate geology geomorphology valley also given attention explain reasons disastrous event june results research presented may important input disaster governance elsevier rights reserved
letter presents image processing technique based theory hilbert transform determine coastal bathymetry marine radar image sequences use hilbert transform enables difficulties complications inhomogeneous image analysis avoided addition number steps complex computations avoided using numerical algorithm hilbert transform hilbert transform suitable monocomponent signals first applied image procedure decompose irregular wave patterns different single wave period images analysis simulated wave field radar image sequences demonstrated high correlation estimated depths reference depths causes errors bathymetry estimations also discussed
effects essential oil eucalyptus camaldulensis flowers oil melanogenesis oil antioxidant characteristics investigated assays mushroom cellular tyrosinase activities melanin content mouse melanoma cells performed spectrophotometrically expression melanogenesis related proteins determined western blotting possible signaling pathways involved essential oil mediated depigmentation also investigated using specific protein kinase inhibitors results revealed camaldulensis flower essential oil effectively suppresses intracellular tyrosinase activity decreases melanin amount mouse melanoma cells essential oil also exhibits antioxidant properties effectively decreases intracellular reactive oxygen species ros levels volatile chemical composition essential oil analyzed gas chromatography mass spectrometry chemical constituents essential oil predominately oxygenated monoterpenes followed oxygenated sesquiterpenes monoterpene hydrocarbons sesquiterpene hydrocarbons results indicated camaldulensis flower essential oil inhibits melanogenesis antioxidant properties regulating mitogen activated protein kinases mapk protein kinase pka signaling pathways present study indicates essential oil potential developed skin care product
comprehensive approach real time simulation power converters using state space representation covered paper systematic formulations state space equations well new switch model presented proposed switch model exhibits natural switching behavior valuable characteristic real time simulation power converters thereby allowing individual treatment switching devices irrespective converter topology successful implementations proposed switch model field programmable gate array fpga device reported two alternative approaches precomputing network equations switch state combinations solving network equations chip using gauss seidel iterative method two level three phase voltage source converter implemented using first approach time step switching frequency khz ideal nonideal boost converters also implemented fpga using second approach time step switching frequency khz comparison spice models shows proposed switch model offers satisfactory accuracy precision
resonate fire models introduced account many phenomena occurring biological neurons showing sub threshold oscillations membrane potential information technology basis chaotic spiking oscillators csos exploitable pulse coupled neural networks pcnns paper illustrates paradigm also used testing analog signal processing structures specifically filters extending oscillation based test obt framework rich dynamics model used encode block test features faults pulse trains directly processable digital level means achieve precise characterization firing times provided used parametric testing considerations trade testing times accuracy provided together practical example simulation data copyright john wiley sons ltd
lapatinib novel oral dual tyrosine kinase inhibitor blocking pathways presented beneficial effects breast cancer positive however efficacy largely limited occurrence acquired drug resistance study aimed explore underlying molecular mechanisms lapatinib resistance using bioinformatics strategies gene expression profile skbr acquired lapatinibresistant skbr lapatinib sensitive cell line downloaded gene expression omnibus database differentially expressed genes degs selected using dchip software furthermore gene ontology pathway enrichment analyses carried using david database finally protein protein interaction network constructed hub genes network analyzed using string database total degs hspa maplca rassf screened functional enrichment analysis showed genes associated cell membrane component related stimulus related binding related items kegg pathway analysis indicated three dysfunctional pathways including ppar signaling pathway cytokine cytokine receptor interaction pathways cancer enriched protein protein interaction network construction revealed hub genes pparg tgfbi tgfbr timp ctgf uba jun might association lapatinib resistance present study offered new insights molecular mechanisms lapatinib resistance identified series important hub genes potential targets treatment lapatinib resistant breast cancer
within last two decades incidence invasive fungal infections significantly increased characterized high mortality rates often caused candida albicans aspergillus furnigatus increasing number infections underlines necessity additional anti fungal therapies require extended knowledge gene regulations fungal infection micrornas regulators important cellular processes including immune response analyzing regulation impact target genes novel therapeutic diagnostic approaches may developed examine role micrornas human dendritic cells fungal infection dendritic cells represent bridge innate adaptive immune systems therefore analysis gene regulation dendritic cells particular significance applying next generation sequencing small rnas quantify microrna expression monocyte derived dendritic cells infection albicans fumigatus well treatment lipopolysaccharides lps identified micrornas differentially regulated infection fungi lps three five specific fungal infections respectively validated interactions mir mir immunological relevant target genes fkbpb klf spn rna protein level results indicate micrornas fine tune expression immune related target genes fungal infection beyond identified previously undiscovered micrornas validated three novel micrornas via qrt pcr comparison known micrornas revealed possible relations mir family mir two third one features unique sequence resemblance known micrornas summary study analyzes effect known micrornas dendritic cells fungal infections proposes novel micrornas could experimentally verified
present study focuses time averaged turbulence characteristics highly spatially heterogeneous gravel bed time averaged streamwise velocity reynolds shear normal stresses turbulent kinetic energy higher order moments velocity fluctuations length scales turbulent bursting measured gravel bed array larger gravels observed turbulence characteristics vary significantly crest level array compared array nondimensional streamwise velocity decreases considerably decrease depth array array reynolds shear stress rss deviates gravity law rss distributions turbulence intensities reduce crest level gravel bed third order moments velocity fluctuations increase crest level gravel bed give clear indication sweeps predominating event verified quadrant analysis plots turbulent length scales values change significantly crest level gravel bed
little known mental health female sex workers women living hiv aids dominican republic impedes hiv prevention testing treatment project estimates prevalence depression identifies key contributing factors outcome female sex workers women living hiv aids comparison group participants female sex workers women living hiv aids comparison group hiv negative women sex workers dominican republic participants completed questionnaires assessing demographic characteristics depression female sex workers women living hiv aids completed additional questionnaires ascertaining hiv sex work related internalized stigma depression prevalent among female sex workers women living hiv aids comparison group adjusted logistic regressions showed internalized stigma associated depression female sex workers women living hiv aids permanent income associated outcome female sex workers comparison group
psychiatric disorders often associated disturbed sleep poor sleep attenuate emotional control including regulation aggression thus may increase risk impulsive aggressive acts cross sectional study aimed investigate potential contribution sleep problems subjective objective aggressiveness impulsivity forensic psychiatric population questionnaires sleep quality pittsburgh sleep quality index chronic severe insomnia sleep diagnosis list aggressiveness aggression questionnaire impulsivity barratt impulsiveness scale completed forensic psychiatric inpatients admitted two forensic facilities netherlands obtain objective measurements aggression impulsivity observational scores professional instrument assess risk future aggression historical clinical future reported aggressive incidents collected files results showed worse sleep quality higher insomnia scores significantly associated self reported aggression impulsivity clinician rated hostility involvement aggressive incidents within facility whether participant professionally judged impulsive could predicted sleep quality insomnia score large extent results study support hypothesis poor sleep related impulsive aggressive behavior forensic psychiatric patients worthwhile examine protective effect treatment sleep difficulties aggressive reactivity forensic psychiatric populations elsevier inc rights reserved
social pressure exerted urban development increase erosion many coastal stretches rise sea level due climate change last decades led governments increase investment coastal protection turn reduction costs increases ease construction rate implementation led sand filled geotextile elements bags tubes containers becoming alternative supplement traditional coastal defence materials rubble mounds concrete coastal zones appropriate sand filled geotextile structures coastal defences article analyses suitable zones locating geotextile bag revetments protect coasts storm erosion concludes least suitable zones surf zone open coast slightly protected coast deep water open coast except suitable reinforcement carried demand makes necessary build kind defence
paper optimized backlight power saving algorithm using joint power peak signal noise ratio psnr characteristics among multiple frames proposed existing state art methods optimal decision clipping point made consideration current frame target frame psnr set frames therefore power psnr performance proposed work show better power psnr performance achieved assigning different target frame psnr different frames proposed algorithm decisions clipping points associated frames made inefficiency ratio clipping point evaluated put algorithm design optimization problem formulated solution search procedure proposed compared state art methods proposed work performs better aspects power psnr psnr power proposed work methods better every tested video psnr power high average power low average
electronic devices using piezoelectric effect contain piezoelectric materials often crystals many cases poled ferroelectric ceramics piezoceramics polymers composites one hand materials exhibit non negligible losses dielectric also mechanical piezoelectric work made simulations effect three types losses piezoelectric materials impedance spectrum resonance analyze independently type loss show differences among hand electrical electronic engineers include piezoelectric sensors electrical circuits build devices need electrical models sensor element frequently material scientists engineers use different languages characteristic material coefficients straightforward translation specific electrical circuit components connect fields study propose use accurate methods characterization impedance measurements electromechanical resonance lead determination types losses alternative current standards introduce simplified equivalent circuit model electrical parameters account piezoceramic losses needed modeling design industrial applications
conventional electrical grid transforming smart grid evolutionary solution satisfy rapidly emerging vibrantly changing requirements utilities customers intelligently leveraging telemetry concepts instrumentation control engineering form communication technology network infrastructure paper presents analogy smart grid industrial process communication technology infrastructure instrumentation telemetry automated metering infrastructure monitoring automation substations power network monitoring home automation network han demand response integration solar identified critical applications reliability scalability interoperability congestion energy efficiency latency security identified critical parameters review recent works presented segment elsevier ltd rights reserved
mood regulation known affected change seasons recent research findings suggested mood regulation may influenced function circadian clocks addition activity brown adipocytes hypothesized contribute mood regulation overarching link mood disorders might circadian clock protein nuclear receptor subfamily group member
citrus greening huanglonbing hlb thought caused candidatus liberibacter asiaticus clas devastating citrus industry worldwide one symptom hlb disease excessive pre harvest fruit drop recently higher incidence lasiodiplodia theobromae diplodia found hlb symptomatic orange calyx abscission zones non symptomatic fruit infection positively correlated reduction fruit detachment force fdf suggesting diplodia infection may involved hlb related pre harvest fruit drop verify hypothesis conducted two experiments experiment conducted shaking hlb affected hamlin valencia orange trees harvest season twice hamlin valencia fruit dropped trees upon shaking collected fruit retained trees shaking harvested fruit ethylene production measured levels diplodia clas fruit analyzed results revealed significantly higher levels diplodia compared fruit ethylene produced half fruit none fruit ethylene production positively correlated diplodia level fruit experiment preliminary trial effect fungicide quadris top application incidence diplodia infection fruit drop investigated experiment conducted commercial grove essentially trees hlb symptomatic included five citrus cultivars early gold orange midsweet orange murcott tangor navel orange ray ruby grapefruit diplodia levels lower fdf significantly higher fungicide treated compared non treated early gold midsweef murcott fruit consequently fruit drop reduced non sprayed controls respectively navel ray ruby fruit significant change sprayed non sprayed controls level diplodia fdf fruit drop results consistently showed positive correlation diplodia infection fruit drop hlb affected fruit indicating possible involvement fungus hlb related excessive fruit drop suggests control diplodia fungal infection field may reduce hlb associated pre harvest fruit drop published elsevier
result loss financial resources need optimize projects academics politicians construction industry become increasingly aware challenges presented frequent time cost overruns reduced quality construction projects purpose study analyze factors project managers experience greatest effect time cost quality discover whether effects factors significantly different questionnaire factors identified interviews sent full population publicly employed project managers factors ranked using relative importance index tested significant differences using friedman test wilcoxon test used post hoc analysis findings determined influential factor time unsettled lack project funding cost errors omissions consultant material quality errors omissions construction work main conclusion research project schedule budget quality level affected significantly different ways therefore project manager handle critical issues focusing schedule budget complications assume time cost quality equally affected american society civil engineers
purpose purpose study compare cutaneous surface parameters lesional non lesional skin psoriatic patients corresponding areas control subjects methods sixty six psoriatic patients grade severity without arthritis without therapy systemic biologic drugs healthy controls enrolled observational case control study exclusion criteria current past sebo psoriasis seborrheic dermatitis pustular erithrodermic psoriasis treatment immune suppressive agents retinoids ultraviolet phototherapy last months topical treatment last weeks corneometry sebumetry phmetry evaluated non lesional skin forehead cheek chin volar region forearm psoriatic plaque elbow neighboring areas controls areas considered results corneometry values significantly lower psoriatic plaques elbows controls sebumetry showed significantly higher values non lesional forearm skin plaques psoriatic patients corresponding areas controls significantly lower areas psoriasis differences found patients treated biologics without arthritis conclusion evaluating surface skin parameters psoriasis useful better understand etiopathogenic mechanism could suggest new therapeutic approaches
essay examines print literature targeting american mothers infants turn twentieth century analyzing text excerpts baby books spanning six decades providing background illuminating texts authors books authored benjamin spock arnold gesell john watson reviewed along work less well known widely read authors emmett holt herman bundesen others changes recommended feeding toilet training practices sleeping arrangements behavioral expectations babies well variation style tone experts advice traced period studied parent advice publications grew popularity changing family structures removed traditional sources information support mothers public came highly regard scientific information seek expert guidance aspects lives previously governed traditional wisdom included publications federal children bureau discussion agency role advising parents printed literature findings review assert despite advice givers presentation recommendations universal scientific writings accurately serve chronicle changing patterns beliefs attitudes middle class society rather empirical body knowledge infant growth development
structure universal micromodule base variety electrical circuits integrating scanning frequency converter isfc offered universal micromodule performed frameless operational amplifiers individually attached components create number secondary resistive sensors output frequency signal provided certain set elements arranged housing universal micromodule communication elements structure generalized block diagram isfc presented component units described structure developed universal isfc module shown schemes inclusion conversion functions output characteristics converter realized basis universal isfc micromodule given results isfc computer schematic modeling presented work device explained formulas graphs dependences output signal frequency measured parameters illustrated timing diagrams recommendations creating secondary converter sensors physical quantities temperature pressure force acceleration humidity etc use isfc universal micromodule given
paper investigates class linear multi agent network systems nodes coupled dynamic edges sense edge dynamic system attached well outputs edge dynamic systems form external inputs node dynamic systems termed neighboring inputs representing coupling actions nodes outputs node dynamic systems inputs edge dynamic systems several cooperative output regulation problems posed including output synchronization output cooperation master slave output cooperation output cooperation specified making neighboring input weighted sum edge outputs track predefined trajectory cooperation node outputs distributed cooperative output regulation controllers depending local states neighboring inputs presented designed combining feedback passivity theories internal model principle simulation example cooperative current control electrical network illustrates potential applications analytical results crown copyright published elsevier ltd rights reserved
background growth development skeletal muscle directly impacts quantity quality pork production chinese indigenous pig breeds exotic species vary greatly terms muscle production performance traits present transcriptome profiles skeletal muscle samples tongcheng yorkshire pigs developmental periods days gestation weeks age using digital gene expression solexa illumina genome analyzer platform investigate differences prenatal postnatal skeletal muscle two breeds results muscle morphological changes indicate importance primary fiber formation dpc days post coitus secondary fiber formation dpc screened differentially expressed genes log ratio probability cluster analysis showed different gene expression patterns pigs transcripts annotated terms gene ontology related muscle development found genes cxcl eifb psma fbxo loc played vital roles muscle regulatory networks breed whereas genes sgcd eng thbd aqp btg played dominant roles breed genes showed breed specific development dependent differential expression patterns furthermore genes identified myogenesis heat map showed significantly enriched pathways fdr stage specific functional regulatory mechanisms finally differentially expressed genes sequencing results confirmed real time quantitative polymerase chain reaction conclusions study detected many functional genes showed differences molecular mechanisms skeletal muscle development pigs pigs showed slower muscle growth complicated genetic regulation pigs many differentially expressed genes showed breed specific expression patterns data provide better understanding skeletal muscle developmental differences valuable information improving pork quality
transactional sex refers commodification body exchange shelter food goods needs transactional sex associated negative health outcomes including hiv infection psychological distress substance use abuse compared body research examining transactional sex among women less known prevalence correlates transactional sex among men using data cross sectional survey young men sex men ages living detroit metro area hiv infected black white latino race multivariate logistic regression analyses examined association transactional sex regular casual partners key psychosocial factors race ethnicity education poverty relationship status hiv status prior sexually transmitted infections stis mental health substance use residential instability previously identified transactional sex literature forty four percent current sample reported engaging transactional sex transactional sex associated age employment status relationship status anxiety symptoms stratified transactional sex regular partner associated age educational attainment employment status relationship status anxiety alcohol use transactional sex casual partner associated homelessness race ethnicity employment status hard drug use implications findings hiv sti prevention discussed including notion efforts address hiv stis among young men sex men may require interventions consider experiences transactional sex psychosocial contexts may increase likelihood
objectivesinterpersonal emotion regulation plays significant role individuals meet others emotional needs shape social interactions key initiating maintaining high quality social relationships given individuals borderline personality disorder bpd asperger syndrome exhibit problems social interactions aim study examine use different interpersonal strategies compared normative control participants methodsthirty individuals bpd age gender education matched control participants completed battery measures assess interpersonal assessed extent participants tended engage interpersonal affect improvement worsening extent used different strategies completing measures groups screened disorders axis axis structured clinical interview dsm axis axis disorders resultscompared controls individuals bpd engaged less affect improvement differences found affect worsening individuals reported use less adaptive attention deployment cognitive change maladaptive expressive suppression interpersonal strategies compared individuals bpd control participants differ conclusionsthe obtained results suggest need develop tailored interventions clinical groups studied furthermore highlight need study potential differences intrapersonal interpersonal clinical populations practitioner points individuals asperger syndrome borderline personality disorder bpd engaged significantly less healthy controls interpersonal affect improvement individuals bpd differ healthy controls use interpersonal strategies individuals reported use maladaptive less adaptive strategies bpd individuals healthy controls understanding differences interpersonal emotion regulation individuals bpd normative controls might help practitioners develop better interventions
background last fifteen years possibility delivering psychoeducation programs internet based platforms explored studies evaluating programs shown good acceptable retention rates context developed smartphone application simple collecting information mood symptoms offering personalized psychoeducation messages main aims study evaluate feasibility acceptability satisfaction smartphone application methods study conducted march august participation study proposed consecutive sample adult patients attending outpatient mental health clinic sociodemographic data clinical functional assessments alongside smartphone ownership uses collected baseline months follow item likert scale satisfaction questionnaire also employed results participants initially enrolled study remained actively using application months whole sample interacted application mean days days completed daily tests participants agreed experience using application satisfactory limitations diversity smartphones operating systems led moderate although representative sample number additionally subjective data reporting narrow time frame use stability patients could affected results conclusions results confirm particular intervention feasible represent satisfactory acceptable instrument self management bipolar disorder add usual treatment future clinical trials must still probe efficacy elsevier rights reserved
paper examines political activity coptic diaspora united states support coptic minority egypt analysing strategy reveals years focused lobbying united states international bodies order raise international awareness coptic minority status using strategy framed struggle copts rights manner contradicts egyptian unity narrative strategic choices struggling paper shows understanding limitations strategy alongside change structure opportunities egypt led change pattern activity diaspora activists alongside lobbying international involvement developed additional strategies including strengthening influence homeland even direct action vis vis egyptian authorities paper emphasises pattern action diaspora activists represent minorities directs attention structure opportunities homeland variety relationships diaspora homeland effect ability diaspora activists become significant force shaping life minority
risk analysis security threats computer networks one challenging fields network management security risk analysis usually done security experts although utilize analysis tools scanners analyzers need expert still inevitable reduce need security expertise network administrator yet performing security risk management paper proposes uml models represent expert security information propose uml class diagram built necessary classes security analysis networks classes building blocks needed estimation probability effects security threats model created represents security information needed analysis analyze network needed objects instantiated provided classes objects form security model network threats risks specified instantiate objects network security model information needed information usually available documents network obtainable via automated scanners show applicability proposed model test network result security model network contains security threats also risks obtained
ammonia best hydrogen carrier safety efficiency transportation engines proposed using ammonia may used single combustion fuel internal combustion engine however difficult fuel concern combustion faster complete combustions may achieved working dual fuel promising alternatives offered using either diesel injection ignition plus port direct injection jet ignition gasoline like fuel gasoline plus port direct injection opportunity diesel injection ignition plus direct injection considered simulations show prospect achieve diesel like power densities efficiencies load control quantity fuel injected critical component prototyping high pressure fuel injection systems specifically developed hydrogen energy publications llc published elsevier ltd rights reserved
tryptophan trp precursor serotonin one investigated amino acids trp supplementation increase levels brain reason numerous studies investigated whether administration trp positively influence social behavior relies serotonergic function review available studies trp clarify circumstances trp supplementation might modulate social behavior trp supplementation seems improve control social behavior patients individuals suffering disorders behaviors associated dysfunctions serotonergic functioning contrast healthy humans trp supplementation seems promote social behavior although research needed disentangle understand relations individual differences trp effectivity functioning social interactions context conclude trp promising tool modulating social behavior elsevier ltd rights reserved
last years motor imagery electroencephalogram eeg based brain computer interface bci systems received significant amount attention various areas including medicine engineering common spatial pattern csp algorithm commonly used method extract features motor imagery eeg however csp algorithm limited applicability small sample setting sss situations rely covariance matrix addition large differences performance depend frequency bands used address problems band eeg signals divided nine subbands regularized csp csp applied individual subbands fisher linear discriminant fld applied features csp extracted individual subbands results obtained foregoing connected subbands make fld score vector furthermore principal component analysis applied use fld score vectors inputs classifier least square support vector machine proposed method yielded classification accuracy five subjects respectively bci competition iii data set iva using channels vicinity motor area cerebral cortex proposed method offers particularly excellent performance sss situations
background knee osteoarthritis common evidence regarding effectiveness braces orthoses patients knee osteoarthritis inconclusive according english language literature english language reviews date included japanese language studies objectives study aimed collect synthesise japanese language randomised controlled trials investigating effectiveness braces orthoses patients knee osteoarthritis study design systematic review methods eight databases systematically searched inception july japanese language randomised controlled trials included risk bias assessed using physiotherapy evidence database scale meta analysis appropriate due heterogeneity included studies results seven randomised controlled trials low high risks bias included six seven included studies conducted author group limited evidence supported positive effects short lever elastic knee braces improve pain functional disability specific outcomes evidence found support use foot orthoses laterally wedged insoles medial arch support metatarsal arch pad conclusion systematic review found conclusive evidence effectiveness braces orthoses patients medial knee osteoarthritis future japanese language studies address methodological flaws exposed review strengthen international evidence base
advanced medical devices exploit advantages embedded software whose development subject compliance stringent requirements standardization certification regimes due critical nature systems paper presents initial results lessons learned ongoing project focusing development formal model subsystem software controlled safety critical active medical device amd responsible renal replacement therapy use formal approaches development amds highly recommended standards regulations motivates recent advancement state art related methods tools including event rodin applied paper expected presented model development approach specification high confidence medical system contribute still sparse experience base available disposal scientific practitioner community formal methods software engineering
modern operating systems use hardware support protect control flow hijacking attacks code injection attacks typically write access executable pages prevented kernel mode execution restricted kernel code pages however current cpus provide protection code reuse attacks like rop aslr used prevent attacks making addresses unpredictable attacker hence kernel security relies fundamentally preventing access address information introduce prefetch side channel attacks new class generic attacks exploiting major weaknesses prefetch instructions allows unprivileged attackers obtain address information thus compromise entire system defeating smap smep kernel aslr prefetch fetch inaccessible privileged memory various caches intel also leaks translation level virtual addresses intel armv build three attacks exploiting properties first attack retrieves exact image full paging hierarchy process defeating user space kernel space aslr second attack resolves virtual physical addresses bypass smap bit linux systems enabling retdir attacks demonstrate unprivileged user programs linux inside amazon virtual machines finally demonstrate defeat kernel aslr windows enabling rop attacks kernel driver binary code propose new form strong kernel isolation protect commodity systems incuring overhead
maternal history childhood maltreatment thought potent risk factor child abuse neglect yet extent continuity across generations unclear studies reporting vastly different rates intergenerational transmission disparate findings may due lack attention nature maltreatment experiences generation sought expand current literature examining role maltreatment type perpetrator identity substantiation status reports child protective services cps intergenerational maltreatment among adolescent mothers children found mothers least one report childhood maltreatment substantiated odds maltreated children increased compared mothers maltreated odds considerably lower limited analysis substantiated reports maternal history substantiated neglect multiple type maltreatment neglect physical sexual abuse associated increased risk child maltreatment yet likelihood children experiencing multiple maltreatment perpetrated mothers identified perpetrators increased mothers childhood history multiple maltreatment elsevier ltd rights reserved
singular point dae ivp fails unique solution hence numerical integration methods provide reasonable results unfortunately common error control strategies always detect circumstances arbitrary solutions may given user without warnings kind automatic algorithmic differentiation opens new possibilities realize analysis daes monitor assumptions required existence uniqueness ivps show diagnosis singular points performed structured quasi linear daes index approach uses projector based analysis daes employing resulting method illustrated several examples particular emphasis simple electrical circuits containing controlled sources
paper proposes novel state space matrix interpolation technique generate linear parameter varying lpv models starting set local linear time invariant lti models estimated fixed operating conditions since state space representation lti models unique similarity transformation state space matrices need represented common state space form needed avoid potentially large variations function scheduling parameters state space matrices interpolated due underlying similarity transformations might degrade accuracy interpolation significantly underlying linear state coordinate transformations set local lti models extracted computation similarity transformation matrices means linear least squares approximations matrices used transform local lti state space matrices form suitable achieve accurate interpolation results proposed lpv modeling technique validated pertinent numerical results elsevier ltd rights reserved
mental health issues increasingly recognized public health problems globally burden projected increase next several decades additional therapies mental problems urgent need worldwide due limitations costs existing healthcare approaches essential oil aromatherapy provide cost effective safe treatment many mental problems pilot study observed effects bergamot essential oil inhalation mental health well measured positive negative affect scale mental health treatment center located utah usa fifty seven eligible participants women age range years included analysis fifteen minutes bergamot essential oil exposure improved participants positive feelings compared control group higher unexpectedly participants participated experimental periods rather control periods suggesting even brief exposure essential oil aroma may make people willing enroll clinical trials study provides preliminary evidence efficacy safety bergamot essential oil inhalation mental well mental health treatment center suggesting bergamot essential oil aromatherapy effective adjunct treatment improve individuals mental health well authors phytotherapy research published john wiley sons ltd
hospital based outpatient interdisciplinary clinics financially viable alternative caring burgeoning population older adults america although highly popular high patient satisfaction rates among older adults families senior health clinics shcs expensive operate limited quantifiable health outcomes study analyzed three geriatric hospital based interdisciplinary clinics rural arkansas examining patient profiles revenues expenses closely examined effects downstream revenue using multiplier effect acknowledged factors weigh heavily success shcs care older adults findings highlight similarities differences three clinics operating financial structures addition clinics providers productivity analysis presents evidence based illustration shcs break even lose large amounts money
objective violent media exposure associated aggressive behavior suggested child health professionals counsel families limiting exposure effective violence prevention counseling requires understanding norms regarding parental attitudes practices influencing factors theories reasoned action planned behavior emphasize subjective norms attitudes affect people perceptions intended behavior data exist violent television viewing monitoring cross section families understanding spectrum parental attitudes community sensitive interventions violence prevention developed objective study assess attitudes monitoring violent television viewing perspective parents methods anonymous self report assisted survey administered convenience sample parents guardians visited child health providers sites urban children hospital clinic urban managed care clinic suburban private practice parent questionnaire included questions child rearing attitudes practices sociodemographic information results total adults accompanied children health visits recruited study surveys completed participation rate total respondents parents complete child data respondents questions television viewing included survey focus analysis seventy five percent families reported youngest child watched television reported always limiting violent television viewing although believed children viewed television violence least time week among television viewers reported usually always limiting viewing sexual content television reported usually always watching television youngest child among children watched television parents reported spent average hours per day watching television limitation television violence associated female parents younger children conclusions variability attitudes practices regarding television violence viewing monitoring among parents attitudes practices varied basis age child gender parent
detecting latency related problems production environments usually carried application level custom instrumentation enough detect high latencies instrumented applications provide information required understand source latency dependent manually deployed instrumentation abnormal latencies usually start operating system kernel contention physical resources locks hence finding root cause latency may require kernel trace trace easily represent hundreds thousands events per second paper propose evaluate methodology efficient algorithms concurrent data structures detect analyze latency problems occur kernel level introduce new kernel based approach enables developers administrators efficiently track latency problems production trigger actions abnormal conditions detected result study working scalable latency tracker efficient approach perform stateful tracing production copyright john wiley sons ltd
location aware service systems hot topic diverse research fields including mobile commerce ambient intelligence remote sensing ubiquitous computing however timeliness efficiency systems two issues rarely emphasized reason study tries establish location aware service system timeliness efficiency service provision addressed end innovative treatments used proposed methodology first uncertainty detecting user location using global positioning system considered modeling location speed user fuzzy numbers subsequently fuzzy integer nonlinear programming model formulated address problem finding dynamic time service location path user help solve problem maximum entropy weighting function basic defuzzification distribution badd method applied defuzzify fuzzy variables addition enhance efficiency solving problem fuzzy parallel processing scheme also proposed decomposing problem smaller pieces handled separate processing modules illustrative example used illustrate proposed methodology finally effectiveness proposed methodology confirmed experiment according results using proposed methodology waiting time could reduced
xylem embolism one main processes involved drought related plant mortality although consequences plant physiology already well described embolism formation spread poorly evaluated modelled especially tracheid based species aim study assess embolism formation spread pinus sylvestris case study using ray microtomography hydraulics methods also evaluated potential effects cavitation fatigue vulnerability embolism micro morphology bordered pits using scanning electron microscopy sem test possible links xylem anatomy embolism spread finally novel model developed simulate spread embolism anisotropic cellular structure results showed large variability formation spread embolism within ring despite differences observed intertracheid pit membrane anatomical traits simulations model showed highly anisotropic tracheid tracheid embolism spreading pattern confirms major role tracheid tracheid air seeding explain embolism spreads scots pine results also showed prior embolism removal samples reduced resistance embolism xylem could result overestimates vulnerability embolism
certain conditions traction machines short axial length relatively large diameter required space constraints allow conventional machine design low number poles distributed winding machine higher number poles tooth coil winding possible solution consequence also lamination steel winding copper skewing machine adapted taking account special properties type machine traction generator short axial length high power density built
billions birds migrate long distances either reach breeding areas spend winter benign places migration passerines frequently stop rest replenish fuel reserves date know little regarding decide ready continue journey physiological signals tell bird brain fuel reserves sufficient resume migration network hormones regulates food intake body mass vertebrates including recently discovered peptide hormone ghrelin show ghrelin reflects body condition influences migratory behavior wild birds measured ghrelin levels wild garden warblers sylvia borin captured stopover site manipulated blood concentrations ghrelin test effects food intake migratory restlessness found acylated ghrelin concentrations garden warblers larger fat scores higher birds without fat stores injections unacylated ghrelin decreased food intake increased migratory restlessness results represent experimental evidence appetite regulating hormones control migratory behavior study lays milestone migration physiology provides missing link ecologically dependent factors condition timing migration addition offers insights regulation hormonal system controlling food intake energy stores vertebrates whose disruption causes eating disorders obesity
background long term care ltc employees high risk cardiovascular disease despite documented benefits worksite health promotion whp programs employees employers potential benefits residents ltc facilities ltc employees rarely offered whp programs purpose purpose intervention described article reduce cardiovascular disease risk factors among ltc workers using physical activity nutrition stress management whp implemented paid work time ltc staff members methods article describes month physical activity nutrition stress management whp intervention delivered paid work time reduce cardiovascular disease risk employees working ltc intervention rooted social ecological model social cognitive theory intervention based formative research evidence based practice recommendations specifically designed reduce barriers intervention participation inconsistent break times unpredictable resident care needs enhance motivators program participation enhanced social support results intervention ongoing measures described conclusion employers offer whp programs important programs tailored meet specific employee groups work environments article operationalizes whp research protocol ltc employees applied reduce cardiovascular disease risk ltc employees similar employee groups similar work environments
aimed compare digital tomosynthesis dts radiographs assessment spinal bone damage patients ankylosing spondylitis study comprised patients underwent dts radiographs cervical lumbar spine day spinal bone damage assessed using modified stoke ankylosing spondylitis spinal score msasss presence facet joint damage wilcoxon signed rank test mcnemar test used compare spinal bone damage two modalities patients mean years disease duration mean msasss radiographs dts grade erosion sclerosis squaring score msasss system higher dts radiographs grade syndesmophyte grade bridge scores particular grade score higher dts radiographs cervicothoracic thoracolumbar junctions regard facet joint damage erosion sclerosis facet joints better depicted dts radiographs cervical lumbar spine dts depicted subtle damage spinal vertebrae patients radiographs moreover erosion sclerosis facet joints better detected dts radiographs
paper analyze asymptotic covariance models causal single input single output linear time invariant systems expressions asymptotic variance system properties estimated using prediction error method derived expressions delineate impacts model structure model order true system dynamics experimental conditions connection results frequency function estimation established also simple model structure independent upper bounds derived explicit variance expressions bounds provided common system properties impulse response coefficients non minimum phase zeros illustration insights expressions provide used derive conditions input spectrum make asymptotic variance non minimum phase zero estimates independent model order model structure elsevier ltd rights reserved
work presents method characterising pipeline defects using small number radiographs taken different angles around pipe method relies knowledge setup geometry use multiple images require calibration objects included setup aimed use situations access difficult subsea pipeline inspections given set radiographs background subtraction method used extract defects images using ray tracing algorithm knowledge experimental setup range possible locations defect space calculated constraints applied potential defect shapes positions refine defect range method tested simulated experimental flat bottomed hole defects simulated corrosion patch defects lateral axial sizes ranging thickness results demonstrate good consistent ability calculate lateral axial defect dimensions within true size defect thickness calculations difficult errors significant cases defect thickness calculated within actual value often closer errors thickness due overestimation meaning calculation could used place maximum limit potential defect size rather actual estimate thickness would still useful example deciding whether defect requires investigation
background hepatocellular carcinoma hcc common liver malignancy worldwide however present studies multiple gene interaction cellular pathways still could explain initiation development hcc perfectly find key genes mirnas well potential molecular mechanisms hcc microarray data gse gse gse analyzed methods microarray datasets gse gse gse including mrna mirna profiles downloaded geo database analyzed using geor functional pathway enrichment analyses performed using david database protein protein interaction ppi network constructed using cytoscape software finally mirdb applied predict targets differentially expressed mirnas dems results total differentially expressed genes degs found hcc including regulated genes regulated genes gene ontology kyoto encyclopedia genes genomes kegg pathway enrichment analyses david showed regulated genes significantly enriched chromosome segregation cell division regulated genes mainly involved complement activation protein activation cascades carboxylic acid metabolic processes oxoacid metabolic processes immune response ppi network nodes highest degree screened hub genes among esr found close interactions foxo cxcl gnao addition total dems identified included regulated mirnas regulated mirnas esr potentially targeted five mirnas including hsa mir hsa mir conclusions roles dems like hsa mir hcc interactions degs esr cxcl may provide new clues diagnosis treatment hcc patients
fuzzy current regulation permanent magnet synchronous generator pmsg designed implemented paper system configuration dynamic model first introduced design fuzzy current regulation demonstrated moreover stability analysis proposed pmsg drive system accomplished control algorithms realized microcontroller renesas rxt performance proposed current regulation verified experimental results
background aims immature platelet fraction ipf represents quote younger larger sized circulating platelets potential marker platelet reactivity major cardiovascular events aimed assess relationship ipf levels prevalence extent coronary artery disease cad patients undergoing coronary angiography methods cohort consecutive patients undergoing coronary angiography single centre included significant cad defined least vessel stenosis severe cad defined left main three vessel disease ipf levels measured admission routine blood cells count sysmex results included patients divided according quartiles values ipf ipf levels directly related active smoke non acute coronary syndrome indication angiography higher levels haemoglobin uric acid respectively lower platelet count angiographic features significantly differ according quartiles values ipf lower degree timi flow patients higher percentage reticulated platelets higher rate lesions involving bifurcations ipf levels affect prevalence cad adjusted severe left main three vessel cad adjusted conclusions present study shows among patients undergoing coronary angiography immature platelet fraction ipf associated prevalence extent coronary artery disease therefore overlooked marker coronary atherosclerosis elsevier rights reserved
efficiency analysis different configurations electric propulsion systems epss presented paper particularly three different permanent magnet synchronous machines pmsms considered electric motor characterized different speed operating ranges constant power speed regions addition four transmission systems arc introduced briefly described single gear multi gear continuously variable magnetic gear transmission among suitable one chosen pmsm accordance inherent features subsequently four epss designed based specific vehicle traction power requirements proposed eps configurations tested three driving cycles order assess efficiency different driving conditions
objective cigarette smoking pregnancy increases risks poor pregnancy outcomes including miscarriage stillbirth pregnancy loss effect smoking pregnancy loss among hiv infected women explored investigated impact smoking risk pregnancy loss among hiv positive hiv negative women estimated potential impact realistic smoking cessation interventions risk pregnancy loss among hiv positive women design analyzed pregnancy outcomes hiv positive hiv negative participants women interagency hiv study methods estimated effects current smoking immediately pregnancy pregnancy loss controlled confounding using regression approaches estimated potential impact realistic smoking cessation interventions using semi parametric formula approach results analysis examined pregnancies among women effect smoking pregnancy loss differed dramatically hiv status adjusted confounding risk difference comparing current smokers current nonsmokers confidence limit hiv positive women confidence limit hiv negative women results robust sensitivity analyses estimated would need offer realistic smoking cessation intervention women prevent one pregnancy loss conclusion smoking highly prevalent exposure important consequences pregnancy hiv positive pregnant women united states even presence potent highly active antiretroviral therapy evidence supports greater efforts promote smoking cessation interventions among hiv positive women especially desire become pregnant author published wolters kluwer health inc
paper investigates research productivity health economists past five years careers date examine quantity overall publications well quantity within categories journals study unique data survey health economists members international health economics association health economics interest group academyhealth basic descriptives indicate senior health economists considerably greater five year research productivity less senior researchers roughly third health economists employed economics departments report publishing non economics journals recommended promotion tenure regression models indicate factors associated greater productivity include hours spent per week research experience type academic unit findings reported offer insight heterogeneity health economists contribute understanding productivity academic economists generally
formation suitable defects levels crucial optical performance electron trapping materials provide wide range applications initial civil uses life sciences energy environmental engineering srgao possessing one dimensional chain structure cations along crystal direction exhibits self activated blue long persistent luminescence lpl related intrinsic defects different trap depths generated forming successive defect structure three dimensional framework srgao containing channels occupied ions introduced captured carriers shallow traps spontaneously released room temperature recombine luminescence center eventually causing characteristic emission deeper traps critically important prevent thermal fading carriers room temperature therefore lpl achieved srgao phosphor furthermore photo stimulated luminescence psl originated ions realized srgao phosphor induced laser diode releasing carriers trapped deeper traps room temperature results infer existence successive defect structure multiple traps incorporation shallow deep ones conducive thermal stability srga phosphor could provide potential application rigorous environment higher thermal energy room temperature solar energy utilization vivo imaging elsevier rights reserved
psychopathy mental disorder marked deficient emotional responses lack empathy poor behavioral controls commonly resulting persistent antisocial deviance criminal behavior accumulating research suggests psychopathy follows developmental trajectory strong genetic influences precipitates deleterious effects widespread functional networks particularly within paralimbic regions brain traditional therapeutic interventions commonly administered prisons forensic institutions notoriously ineffective combating outcomes alternative strategies informed understanding specific neuropsychological obstacles healthy development target younger individuals nascent symptoms psychopathy promising review recent neurobehavioral neuroimaging literature informs understanding brain systems compromised psychopathy apply data broader understanding developmental course ultimately promoting proactive intervention strategies profiting adaptive neuroplasticity youth
catchbasins also known gully pot australia used receive surface runoff drain stormwater storm sewers recent interest catchbasins improve effectiveness removing sediments stormwater experimental study conducted examine hydraulic features sediment capture efficiency catchbasins without bottom sump sump basin found increase sediment capture efficiency significantly effect inlet control devices commonly used control amount flow downstream storm sewer system also studied devices increase water depth catchbasin increase sediment capture efficiency equations developed predicting sediment capture efficiency catchbasins
aim campos rupestres species rich tropical mountain grasslands southeast brazil threatened mining quarrying eight years following strong disturbance quarrying gravel exploitation asphalting highway spontaneous succession occur degraded areas study therefore designed test restoration technique hay transfer means enhancing seed dispersal reference ecosystems degraded areas location campo rupestre grasslands serra cipo minas gerais brazil methods nine degraded areas representing three kinds substrate latosol sandy stony selected hay transfer carried using hay collected two kinds grassland campos arenosos campos pedregosos year round order maximize seed pool collected hay distributed quadrats among three types substrate without geotextile according following protocol hay campo arenoso grasslands spread types substrate hay campo pedregoso grasslands used stony substrate results seedlings emerged within treatment application despite large number seeds contained hay indicating hay transfer may useful method restoring degraded areas campos rupestres seedlings emerging degraded areas mainly belonged ruderal species therefore suggest although poor soil conditions could limit seedling establishment germination issues campo rupestre species first limitation restoring degraded campos rupestres using hay transfer conclusion results highlight inherent difficulty restoring degraded areas campos rupestres protection must made high conservation priority
analog signal processing applications settling performance employed operational amplifiers opamps usually great matter low voltage environment modern technologies transistors allowed stacked three stage amplifiers gaining interest unfortunately design optimization three stage opamps based settling time still suffer lack comprehensive analysis settling behavior closed form relations settling time error parameters paper thorough analysis settling response three stage nested miller compensated opamps including linear non linear sections presented analysis leads design methodology determines circuit requirements desired settling time error based settling time allows optimizations power consumption area copyright john wiley sons ltd
approach performing linguistic summaries graph datasets particular focus usage ontologies presented paper well known mining technique based fuzzy set theory used model natural language words many tall result generates natural like sentences describing data although intensely developed work method applied relational databases data available graph model special case graph datasets semantic web ontologies provide meaning therefore enabling advanced machine learning paper analyze problem generating linguistic summaries graph data case method directly applied associated ontologies key element ontologies concept hierarchies core work firstly due heterogeneity lack schema propose use ontological concept including sub concepts hierarchy subject summaries extract attributes neighboring vertexes show ascending ontological concept hierarchies attribute based induction obtain additional generalized summaries showthis process summarizers qualifiers propose extension respective imprecision measures perform two experiments dbpedia one summary subject artist second musical album latter show optimized process obtaining truth values using bottom approach
present study tested whether children play feminine toys related social abilities girls typically excel measured gender typed toy play empathy comforting skill grade children years old hong kong china toy play assessed standard observational paradigm empathy empathy quotient child questionnaire comforting skill infant cry paradigm requiring generation comforting strategies predicted boys girls differed preferences play masculine feminine toys gender neutral toys importantly toy play related comforting skill girls scored higher comforting task girls played feminine toys boys played gender neutral toys generated comforting strategies regression mediational analyses also suggested stronger role gender typed play comforting way round contrary hypothesis gender difference empathy relationship empathy toy play results extend previous understandings link play development suggest early gender typed experiences may long term consequences development social skills
hatred terrorists obstacle implementation effective counterterrorism policies invites indiscriminate retaliation whereas many greatest successes counterterrorism come understanding terrorists personal political motivations drawing psychological research traditional prejudice reduction strategies generally well suited task reducing hatred terrorists instead studies explored education potential ability reduce extreme negative attitudes toward terrorists study compared students college course terrorism treatment wait listed students measuring prosocial attitudes toward hypothetical terrorist initially students reported extremely negative attitudes however end semester treatment students attitudes significantly improved study replicated effect within sample treatment control classes drawn universities across united states present work part ongoing research project focusing foreign policy perceived threat terrorism thus classes explicitly aim reduce prejudice making effect treatment somewhat surprising one possibility learning terrorists crowds initial pejorative associations label terrorism may ultimately call information mind diluting initial negative associative links alternatively students may learn challenge label terrorist applied either case learning terrorism decrease extreme negative reactions evokes desirable one wishes implement effective counterterrorism policies
paper process program model universal microelectromechanical systems data extracting update mechanism different relational databases nosql database mongodb described
reported one developed green building markets country wide success must start success different local markets many important local green building markets areas became important answers provide useful implications developing countries like china better promote green building markets explore question numerical way study therefore collected data green building projects clustered important regions analyzed numerical patterns behind based different features covering demography economy education climate policy non linear machine learning algorithms help find economic factors educational factors one influential features discoveries also implemented china suggest areas focus developing chinese green building market elsevier ltd rights reserved
background across cancers decision pursue genetic testing influenced subjective objective factors however skin cancer prevalent visual multifactorial many malignancies may offer different motivations pursuing testing objectives primary objective determine factors influencing decision receive genetic testing skin cancer risk secondary objective assess impact priming health questions decision receive testing methods distributed anonymous online surveys researchmatch org assess participant health demographics motivations interest pursuing genetic testing skin cancer risk two surveys identical questions different question ordering used assess secondary objective results received responses response rate desired testing subjective factors including curiosity perceptions skin cancer anxiety statistically significant determinants decision pursue testing followed history sun exposure odds ratio history skin cancer odds ratio age family history skin cancer influence decision participants increasingly chose testing first queried health behaviors limitations decision pursue hypothetical testing may differ clinic decision making self selected online participants may differ general population surveys may subject response bias conclusion decision pursue genetic testing skin cancer primarily determined subjective factors anxiety curiosity health factors including skin cancer history also influenced decision making priming consideration objective health factors increase desire pursue testing
agomelatine first approved antidepressant mediates activity melatoninergic pathway rather monoaminergic system meta analysis aims summarize date report efficacy agomelatine major depressive disorder archives published results pubmed cinahl cochrane library embase psycinfo databases searched randomized double blind trials comparing agomelatine placebo antidepressant major depressive disorder change severity depression result intervention main outcome measure data necessary compute standardized mean difference smd outcome additional sample parameters likely influence main outcome extracted selected studies summary effect sizes various groups subgroups computed smds agomelatine control placebo antidepressants arms nine trials involving severe cases depression agomelatine either placebo antidepressants agomelatine stood superior placebo small margin smd superiority agomelatine dose antidepressants paroxetine fluoxetine sertraline venlafaxine even smaller smd although evidence superiority agomelatine placebo selected antidepressants questionable whether magnitude effect size clinically significant sample characteristics relevant general patient population major depressive disorder
much media violence research occurred principally united states based fundamental epistemological error correlation variables consumption media violence acted aggression inferred many researchers causal relationship article suggests scholars infer causation correlation miss important point propose rescue deeply flawed literary corpus applying statistical principles account theoretical methodological disarray much media violence literature disarray invalidates probabilistic calculations article suggests rather argue causal hypothesis productive untangle conceptual methodological confusion bobbles study area product could dissolution causal argument putative causal relationship society consumption media violence social aggression may disappear
characterization land displacement induced long term overexploitation groundwater necessary ensure sustainable water supply beijing china northern part beijing plain important water source area also designed groundwater recharge south north water diversion project aim depict process characterizing land displacement complex hydrogeological geological context region using remote sensing geographic information system interferometric synthetic aperture radar time series analysis used detect land displacement statistic linear regression equations groundwater level land displacement built based linear consolidation principle spatial difference pearson correlation coefficient slope discriminated quantify response land displacement groundwater level change results show two major displacement cones annual rates year negative positive correlation increasing land displacement respectively larger reflects groundwater level closer relation occurrence land displacement weak correlation due delay propagation pressure drawdown fine sediment layers lens pumped aquifers pressure measured thick compressible layer potential land displacement results study necessary clarify land displacement characteristics make full use abundant spatial temporal dataset ultimately support hazard prevention mitigation decisions
despite widespread applications tetravalent cerium compounds organic synthesis catalysis coordination organometallic chemistry cerium complexes well explored due part high oxidizing power using chelating donor supporting ligands stable tetravalent cerium complexes bearing various ligand functionalities isolated thus making possible investigate reaction chemistry cerium complexes systematically review summarizes recent developments coordination chemistry cerium complexes bearing donor ligands special attention directed cerium complexes supported tripodal oxygen ligand elsevier rights reserved
psoriasis common chronic inflammatory disease helper helper cells play important role pathology formula psori novel formulated chinese medicine used psoriasis therapy demonstrated previously psori serum contained formula psori pcmocs could improve psoriasis inhibiting epithelial hyperplasia psori affects inflammatory cytokine chemokine dermis still unknown study found psori pre treated days imq painting could ameliorated imq induced mice skin lesion pasi score apparently reduced related cytokine ifn gamma related cytokine used induce inflammatory models human keratinocyte cell line hacat vitro respectively pcmocs significantly reduced ifn gamma induced mrna expression cxcl reduced cxcl release hacat supernatant stimulation significantly upregulated expression ccl mrna expression hacat cells pcmocs significantly inhibit cytokines expression mrna protein levels finally pcmocs could obviously inhibit nuclear kappa expression activated ifn gamma stimulation thus new findings reveal formula psori may possess therapeutic action psoriasis inhibiting inflammatory within skin environments published elsevier
paper show apply grobner bases compute drazin inverse matrix multivariate rational functions entries coefficients rational functions depend parameters give sufficient conditions drazin inverse specialize properly addition extend method weighted drazin inverses present empirical analysis shows good timing performance method elsevier inc rights reserved
paper performance radial fuel shuffling sodium cooled breed burn reactor core investigated neutronics depletion calculations carried mcore based endf vii data library thermal hydraulic analysis performed based self developed parallel channels model steady state code sast first assembly parameters optimized neutronics thermal hydraulics results show assembly fuel rods pad best design secondly core critical features radial power peaking factors inward outward fuel shuffling strategy different fuel shuffling periods carried results show eff beginning equilibrium cycle boec end equilibrium cycle eoec inward outward fuel shuffling strategy parabolically vary fuel shuffling period power peaking factor inward fuel shuffling strategy decreases increase fuel shuffling period exponentially outward fuel shuffling strategy increases fuel shuffling period exponentially outward fuel shuffling strategy shuffling period days performs better core critical features radial power peaking factors reactivity coefficients optimized core calculated finally preliminary thermal hydraulic analysis optimized core performed results show maximum cladding interface temperature maximum fuel temperature within acceptable limits elsevier ltd rights reserved
comprehensive analysis framework study green building incremental cost given paper perspective whole life cycle discuss concept characteristics incremental cost providing overall process whole stage full range recognition quantitative based overall analysis factors build framework cost whole life cycle provide important theoretical practical significance study development green building
rapid growth population becomes difficult control huge amount residual materials generated enormous industrial activities residuals recycled reclaimed reused constitute wastes get released environment wastes assimilated environment become hazardous environment quality ensure pollution paper expresses concern two industrial wastes used plastic water bottles fly ash present study emphasizes reuse used waste plastic water bottles civil engineering applications regard discusses previous work dutta mandal two different type plastic water bottles different diameter tensile stiffness chosen prepare perforated cells different heights wrapped jute geotextile inner side fine infill materials escape perforations laboratory strain controlled compression tests carried cells rested rigid base filled compacted fly ash stone aggregates test results showed significant load carrying capacity composite cells fly ash infill material though fine fly ash appeared effective infill material use coarse stone aggregates infill material produced better load carrying capacity composite cells also observed reduction cell height rigid base load carrying capacity composite cells got increased study confirmed plastic bottles suitable infill material act ideal compression member authors published elsevier
sex parties environments men sex men msm opportunity sex multiple partners brief period time dim lighting nonverbal communication characteristics sex parties make sexual communication challenging report qualitative data msm attended sex parties new york city participants responded distinct hypothetical scenarios involving use color coded wristbands communicate condom use preferences sexual position top bottom human immunodeficiency virus hiv status sex parties majority positive neutral attitudes toward color coded wristbands indicate condom use preference sexual position hiv positive hiv negative respectively men cited wristbands would facilitate process pursuing partners similar interests also avoiding discomforts verbal communication contrast hiv positive hiv negative men expressed unfavorable attitudes using wristbands communicate hiv status men cited potential hiv status discrimination well suspicions around dishonest disclosure although participants receptive utilizing color coded wristbands sex parties convey certain information may unfeasible use wristbands communicate hiv status
localization tracking recognition objects humans basic tasks high value applications ambient intelligence sensing floors introduced address tasks non intrusive way recognize humans moving floor usually first localized set gait features extracted stride length cadence pressure profile footstep however recognition generally fails several people stand walk together preventing successful tracking paper presents detection tracking recognition technique uses objects weight continues working even tracking individual persons becomes impossible inspired computer vision technique processes floor pressure image segmenting blobs containing objects tracking recognizing contents mix inference combinatorial search result lists probabilities assignments known objects observed blobs concept successfully evaluated daily life activity scenarii involving multi object tracking recognition low resolution sensors crossing user trajectories weight ambiguity technique used provide probabilistic input multi modal object tracking recognition systems
many neurodegenerative diseases characterized formation microscopically visible intracellular protein aggregates synuclein key aggregating protein parkinson disease characterized neuronal cytoplasmic lewy body inclusions previous studies shown relative sparing neurons parkinson disease dementia lewy bodies positive vitamin dependent calcium buffering protein calbindin synuclein aggregates excluded calbindin positive neurons recent cell culture studies shown synuclein aggregation induced raised intracellular free demonstrated raised intracellular calcium oxidative stress act synergistically promote synuclein aggregation hypothesized calcipotriol potent vitamin analogue used pharmaceutically may able suppress calcium dependent synuclein aggregation inducing calbindin expression immunofluorescence western blot analysis showed calcipotriol potently induced calbindin dose dependent manner syy human neuroblastoma cells calcipotriol significantly decreased frequency synuclein aggregate positive cells subjected treatments cause raised intracellular free potassium depolarization kcl combined treatment rotenone dose dependent manner increased viability suppression calbindin expression calcipotriol treated cells using calbindin specific sirna showed significantly higher synuclein aggregation levels indicating calcipotriol mediated blocking calcium dependent synuclein aggregation dependent induction calbindin expression data indicate targeting raised intraneuronal free brain promoting expression calbindin transcriptional level using calcipotriol could prevent synuclein aggregate formation ameliorate parkinson disease pathogenesis
objective innate adaptive immune responses contribute onset chronic inflammation spondyloarthritis spa association spa inflammatory bowel disease ibd enteropathic spa espa largely established suggests shared pathophysiology evidence innate lymphoid cells ilc involved pathogenesis spa ibd evidence reported date espa aimed analyse first time frequency cytokine expression ilc peripheral blood espa patients compared ibd healthy subjects correlations immunophenotyping disease activity also explored methods espa patients prospectively enrolled healthy controls ibd patients served control groups peripheral blood interferon ifn gamma interleukin expressing non cells well ilc subsets ilc ifn gamma ilc natural killer characterised flowcytometry correlations cells spa disease activity analysed results espa patients showed higher levels ror gamma expressing non cells respect controls producing non cells higher positively correlated ifn gamma expressing cells levels well spa disease activity espa showed higher levels ilc ilc ibd ifn gamma expressing cells higher espa conclusion preliminary findings indicate peripheral blood espa patients enriched expressing ilc distinguishes blood compartment ibd increased production ilc indicates novel role ilc espa
using human cathepsin targeting inhibitor screen new leupeptin analogue leupeptazin containing unprecedented piperidinotriazine moiety isolated liquid culture soil streptomyces collected northern italy structure leupeptazin established using hresims well nmr data inhibitory activity compound towards collagenase cathepsin tested vitro reveal moderate activity inhibition constant elsevier ltd rights reserved
objective infection deep brain stimulation dbs hardware significant impact patient morbidity previous experience suggests infection rates appear higher implantable pulse generator ipg replacement surgery novo dbs procedure study authors examine effect change practice dbs ipg replacements institution methods starting january patient screening methicillin resistant staphylococcus aureus mrsa necessary eradication performed prior elective dbs ipg change moreover topical vancomycin placed ipg pocket surgery authors prospectively examined infection rate patients undergoing dbs ipg replacement center year period least months follow results total incidence infection prospective consecutive series ipg replacement procedures mean follow duration months significantly lower authors previously published historical control group prior implementing change practice infection rate ipg replacement procedures conclusions study suggests change clinical practice significantly lower infection rates patients undergoing dbs ipg replacement simple measures minimize unnecessary surgery loss benefit chronic stimulation costly hardware replacement improving cost efficacy dbs therapies
purpose previous studies shown prenatal testosterone affects development reproductive organs also brain even glucose metabolism whether prenatal testosterone influences kidney development largely unknown analyzed whether testosterone modulation prenatal development would affect renal function number nephrons adult offspring materials methods pregnant rats treated olive oil testosterone androgen receptor blocker flutamide testosterone plus flutamide via daily intramuscular injections gestation day delivery renal histology functional parameters assessed male female adult offspring macerated kidneys used nephron counting results prenatal testosterone administration increased proteinuria male rats similar effect female rats statistically significant effect prevented flutamide administered male rats prenatal testosterone increased blood urea nitrogen female rats flutamide increased creatinine clearance male rats prenatal testosterone flutamide led higher lower respectively interstitial collagen deposition adulthood conclusions prenatal testosterone induces proteinuria adulthood effect mediated via androgen receptor additional effects seem sex specific studies focus timing dosing testosterone well applicability human development
urinary incontinence common heterogeneous among women limited knowledge progression prognosis evidence based clinical epidemiology help better understand natural history examine challenges definition subtypes impact quality life health seeking behavior review proposed pathophysiology subtypes known risk factors relate current knowledge disease state finally emphasize role epidemiology process acquiring new insight improving knowledge translating information clinical practice stress common overall mixed prevalent older women three subtypes common risk factors others unique remains significant gap understanding develop although pathophysiology stress somewhat understood urgency remains mostly idiopathic whereas mixed least studied complex subtype moreover exists limited information progression symptoms time disproportionate health seeking behavior identify areas exploration epigenetics urinary microbiome offer new insights better understanding relationship among subtypes develop integrated construct natural history future epidemiological strategies using longitudinal study designs could play pivotal role better elucidating controversies natural history pathophysiology subtypes leading improved clinical care
manning empirical formula conjunction strickler scaling widely used predict hulk velocity hydraulic radius roughness size slope energy grade line uniform channel pipe flows high bulk reynolds numbers despite importance science engineering manning strickler formulations waited decades finding theoretical explanation provided first time gioia bombardelli phys rev lett vol labelled using phenomenological arguments perhaps remarkable finding link strickler kolmogorov scaling exponents latter pertaining velocity fluctuations inertial subrange turbulence spectrum presumed universal work analysis first revisited showing employed several hoc scaling assumptions turbulent kinetic energy dissipation rate although implicitly mean velocity gradient adjacent roughness elements similarity constants arising scaling assumptions presumed independent inconsistent well known flow properties near wall region turbulent wall flows dependence similarity constants existing theory requires validity strickler scaling cancel dependence constants rirh arrive strickler scaling manning formula approach corroborated using spectral budget csb model wall shear stress formulated cross roughness sublayer log region assuming simplified shape spectrum vertical velocity proposed csb model subject another simplifying assumption production balanced pressure velocity interaction allows manning formula derived substantiate approach numerical solutions csb entire flow depth using different spectral shapes carried wide range results analysis support simplifying hypotheses used derive manning equation derived equation provides formulation agrees reported values literature seven decades variations none investigated spectral shapes allows recovery strickler scaling numerical solutions csb reproduce nikuradse data fully rough regime thereby confirming strickler scaling represents approximate fit friction factor granular roughness
paper effect hydrogen addition ethanol monorotor wankel engine wide open throttle position ultra lean operating regime experimentally investigated aim variation hydrogen enrichment levels ethanol engine performance emissions considered experiments carried constant engine speed rpm fixed spark timing degrees btdc test results showed hydrogen enrichment improved combustion process shortening flame development flame propagation periods reducing cyclic variation furthermore reduction burn duration increase hydrogen fraction enhances thermal efficiency reducing brake specific energy consumption well reducing unburned hydrocarbons emissions wankel engine elsevier ltd rights reserved
background aimscannabis alcohol commonly used licit drugs world wide compared effects cannabis alcohol use within person changes impulsivity hostility positive affect momentary daily levels occurred daily life designobservational study involving ecological momentary assessments collected via electronic diaries six random times day consecutive days settingout patients everyday life contexts columbia usa participantsninety three adult psychiatric patients female mean years old borderline personality depressive disorders reported using cannabis alcohol least study period measurementsreal time standard self report measures impulsivity hostility positive affect impacted momentary reports cannabis alcohol use findingscannabis use associated elevated feelings impulsivity day level confidence interval increased hostility momentary person level alcohol use associated elevated feelings impulsivity momentary day levels increased positive affect momentary day levels conclusionscannabis alcohol use associated increases impulsivity hostility cannabis positive affect alcohol daily life effects part separate processes operate different time scales momentary versus daily
daily return realized volatility simultaneously modeled stochastic volatility model leverage long memory dependent variable stochastic volatility model logarithm squared return error distribution approximated mixture normals addition logarithm realized volatility incorporated measurement equation assuming latent log volatility follows autoregressive fractionally integrated moving average arfima process describe long memory property efficient bayesian estimation method using markov chain monte carlo method mcmc proposed implemented state space representation model comparisons performed based marginal likelihood volatility forecasting performances investigated using stock index returns elsevier rights reserved
background iliac crest bone graft harvesting routinely performed upper extremity orthopedic procedures despite high complication rates associated sensory nerve injury hematoma chronic pain fracture description technique cancellous bone graft harvested proximal tibia using medial approach minimizing donor site morbidity patients methods retrospective review undertaken patients underwent cancellous proximal tibia bone graft harvesting augment healing wrist reconstruction months minimum follow report donor limb tourniquet time time union visual analog scale vas pain score complications patients also contacted phone administer retrospective questionnaire record experiences harvesting technique results average donor site vas immediate postoperative period average tourniquet time minutes average time union recipient site days one patient experienced delayed union corrective osteotomy attributed osteoporosis two patients underwent hardware removal operative wrist unrelated bone graft harvesting one patient history chronic neuropathy foot drop developed dysesthesia allodynia ipsilateral ankle asymptomatic proximal tibia donor site ankle symptoms resolved weeks postoperatively patient reported residual donor site difficulties months postoperatively conclusion consideration minimal complication rate favorable clinical parameters excellent patient tolerance advocate proximal tibia bone graft harvesting opposed iliac crest harvesting wrist reconstruction moderate amount autogenous cancellous graft needed
inherited disorders platelet granules clinically heterogeneous prevalence underestimated patients undergo complete diagnostic work lack genetic diagnosis limits ability tailor management screen family members aid family planning predict clinical progression detect serious consequences myelofibrosis lung fibrosis malignancy timely manner set change introduction high throughput sequencing hts routine clinical diagnostic test hts diagnostic tests available affordable allow parallel screening dna samples variants known bleeding thrombotic platelet genes increased genetic diagnosis curation variants turn improving understanding pathobiology clinical course inherited platelet disorders understanding genetic causes platelet granule disorders regulation granule biogenesis work progress significantly enhanced recent genomic discoveries high powered genome wide association studies genome sequencing projects era whole genome epigenome sequencing new strategies required integrate multiple sources big data search elusive novel genes underlying granule disorders
subcritical flow short expansion tends become detached sidewalls create turbulent eddies phenomenon cause undesirable losses flow energy channel erosion paper numerically investigates effects triangular hump fitted bottom expansion flow separation reduction results validated using available experimental data paper reports quantitative details velocity field eddy structures flow streamline separation expansions different divergence angles various conditions froude number results show flow water separate along either two sidewalls possibly due bistability use appropriate humps effectively reduce separation turbulent eddies force flow accelerate hence create favorable pressure gradient results paper useful optimal design expansions important part irrigation water systems
psychosocial function adherence antiretroviral regimen key factors human immunodeficiency virus hiv disease management alexithymia trait deficit ability identify describe feelings emotions bodily sensations structural equation model used test whether high levels indirectly relate greater non adherent behavior hiv disease severity via psychosocial dysfunction blood draws hiv viral load lymphocyte along psychosocial surveys collected hiv positive adults aged years structural model supports significant paths non active patient involvement psychological distress lower social support psychological distress non active involvement non adherent behavior non adherence greater hiv disease severity cfi rmsea srmr second model confirmed intermediary effect greater patient assertiveness path social support non active patient involvement cfi rmsea srmr altogether indirectly linked hiv disease management association poor psychosocial function however greater patient assertiveness buffers negative impact relationship quality healthcare providers members one social support network
introduction diffuse large cell lymphoma dlbcl common histotype non hodgkin lymphoma peak incidence sixth decade standard treatment elderly fit dlbcl patients rituximab chop unfit frail patients chemotherapy reduced intensity considered areas covered article review use standard therapies new drugs investigated immonomudulating agents imids bruton tyrosine kinase btk fit unfit frail elderly dlcbl patients expert commentary chop fit dlbcl patients still standard care elderly unfit patients reduction doses cytotoxic drugs schemes avoid antracycline considered comprensive geriatric assesment based age comorbidities functional abilities daily living important tool elderly order discriminate fit unfit frail patients novel drugs represent valid therapeutic options relapsed refractory setting continued participation clinical trials encouraged
premise study dna metabarcoding broad ranging applications ecology aerobiology biosecurity forensics bioinformatics pipeline recently published identification using comprehensive database one common plant dna barcoding markers however corresponding database rbcl primary marker used plants methods using publicly available data compiled reference library rbcl sequences trained databases use utax rdp classifier algorithms used reference library along existing bioinformatics pipeline reference library identify species artificial mixture nine species pollen made database publicly available multiple formats allow use multiple bioinformatics pipelines future results using rbcl database addition database succeeded making species level identifications eight species family level identification ninth species improvement sequence alone discussion reference library described assist identification plant species using rbcl making another gene region available standard barcoding increase resolution accuracy identifications
capillary electrophoresis important analytical separation method used study wide variety samples including biological origin capillary electrophoresis may covered classroom especially advanced analytical courses many students exposed gel electrophoresis biology biochemistry laboratories capillary electrophoresis commonly found undergraduate lab curricula published lab experiments incorporate capillary electrophoresis include analysis caffeine beverages cations water samples biological samples peptide mixture paper introduces peptide separation based capillary zone electrophoresis qualitative quantitative describes separation four small peptides two analytes similar migration times forcing students think best identify peak corresponds analyte exposing bioanalytical application capillary electrophoresis
magnetically levitated planar motor new generation motion device modern precision industry advanced motion controller design still main concern paper learning adaptive robust control larc motion controller proposed magnetically levitated planar motor developed laboratory achieve good tracking performance planar motor consists halbach permanent magnetic array stator levitated platen containing four groups three phase windings mover based lorentz force law mover placed magnetic field subjected vertical force levitation horizonal force planar motion dynamics decoupling current allocation larc control scheme containing adaptive robust control arc term iterative learning control ilc term serial structure proposed magnetically levitated planar motor achieve high performance tracking even exist parametric variations uncertain disturbances comparative experiments traditional lead arc ilc proposed larc carried planar motor track sinusoidal point point planar circular motions respectively experimental results consistently validate proposed larc control strategy outperforms controllers much possesses good transient steady state tracking performance also parametric adaptation ability uncertain disturbance robustness proposed scheme actually provides practically effective technique motion control magnetically levitated planar motors industrial applications
paper presents fine grain parallel version delaunay kernel procedure using openmp open multi processing api set points taken input initially sorted along space filling curve two points close insertion order also close geometrically sorted set points divided subsets equal size multithreaded version delaunay kernel inserts points time triangulation openmp barriers provide required synchronization needed multiple insertion order avoid data races simple approach exhibits two standard problems parallel computing load imbalance parallel overheads two issues addressed using two level version multithreaded delaunay kernel tests show triangulations billion tetrahedra generated core machine intel xeon ghz memory less minutes wall clock time speedup compared single threaded implementation published elsevier ltd
objective study aims determine whether emergency contraceptive pills ecps less safe effective women obesity compared without obesity study design searched pubmed articles november regarding safety effectiveness ecps ulipristal acetate upa levonorgestrel lng combined estrogen progestin among obese users assessed study quality using united states preventive services task force evidence grading system results identified four pooled secondary analyses quality poor fair two examined upa three examined lng formulations three analyses pooled overlapping data total three primary studies demonstrated significant associations obesity risk pregnancy ecp use one analysis reported fold increased risk pregnancy among women obesity bmi compared women within normal underweight categories bmi use lng ecps odds ratio confidence interval analysis lng data found approximate weight rate pregnancy rose estimated pregnancy probability without contraception weights less rate pregnancy less two analyses examining upa suggested approximate fold increased risk pregnancy among women obesity compared either normal underweight women nonobese bmi women respectively cis wide finally fourth secondary analysis pooled data three separate randomized controlled trials lng ecps found increase pregnancy risk increasing weight bmi found consistent association pregnancy factors adjusted covariates conclusion data limited poor fair quality findings suggest women obesity experience increased risk pregnancy use lng ecp compared normal underweight women obesity may also experience increased risk pregnancy compared women without obesity use upa ecp though differences reach statistical significance providers counsel women risk unintended pregnancy including obesity effectiveness full range emergency contraception options order understand options receive advanced supplies emergency contraception needed understand access emergency copper intrauterine device desired published elsevier inc
green building incentives important promoting green building however lacks systematic review existing knowledge paper aims elicit common themes studies green building incentives systematic review found common research areas green building incentives incentive categorisation effectiveness promoting green building development criticism current green incentive implementation strategies improving green building incentives green building incentives categorised external internal incentives external incentive forced choice whereby beneficiaries required fulfil specified conditions requirements benefitting internal incentive allows beneficiaries incentivised volition appeal benefits green buildings external incentives largely provided government divided financial non financial incentives found owners incentivised non financial incentives terms effectiveness external internal incentives important instruments promoting green building although clear effective furthermore review uncovered criticisms external green building incentives mainly focus shortcomings administering incentives government strategies improving green building incentives also found important need government redirect approach providing incentives owners encouraged pursue green building review findings signify importance government relation green building incentives research areas could expand knowledge green building incentives also recommended elsevier ltd rights reserved
background international study asthma allergies childhood isaac reported highest prevalence symptoms severe asthma found low middle income countries lmics including nigeria exposure biomass fuel use may important risk factor development asthma association asthma symptoms severity well established aim study extend spectrum environmental risk factors may contributing towards increasing asthma morbidity especially asthma symptoms severity rural schoolchildren nigeria examine possible asthma underdiagnosis among population methods authors conducted cross sectional survey three rural communities nigeria asthma symptoms defined according isaac criteria information types household fuel used cooking used determine household cooking fuel status asthma symptoms severity defined based frequencies wheeze day night time symptoms speech limitations logistic regression analyses used explore associations results total nigerian schoolchildren participated study overall diagnosed asthma possible asthma asthma related symptoms diagnosed asthma children biomass fuel households higher proportion possible asthma symptoms severe asthma adjusted analyses biomass fuel use associated increased odds severe symptoms asthma odds ratios possible asthma conclusion rural nigerian children asthma symptoms use biomass fuel cooking associated increased risk severe asthma symptoms additional evidence rural children might underdiagnosed asthma
digital stabilization unstable equilibria linear systems may lead small amplitude stochastic like oscillations show vibrations related deterministic chaotic dynamics induced sampling quantization detailed analytical proof chaos presented case controlled oscillator shown exists finite attracting domain phase space largest lyapunov exponent positive existence smale horseshoe also pointed corresponding two dimensional micro chaos map multi baker map consists finite series baker maps
larger number individuals born congenital heart disease living adolescence young adulthood comes responsibility counsel patients regarding sexual reproductive health study utilizes representative data national health nutrition examination survey compare sexual measures including percentage sexually active age first sexual activity number sexual partners condom use history sexually transmitted diseases without congenital heart disease total patients without congenital heart disease congenital heart disease included study likelihood sexually active age first sexual intercourse condom use differ significantly two groups multivariate analysis incidence sexually transmitted disease differ two groups multivariate analysis except genital warts major differences sexual measures without congenital heart disease absence significant differences sexual measures congenital heart disease compared general population places group individuals increased health risk known occur pregnancy
thyroid hormones vital control multiple body functions including correct performance brain multiple diseases associated thyroid gland functioning including hypothyroidism date little known regarding effects establishment condition young age brain function evaluated effect hypothyroidism early postnatal stage cognitive abilities focus hippocampus model hypothyroidism induced young rats days age using propyl thiouracil ptu weeks reaching significantly lower levels control ptu following induction hypothyroidism several cognitive tasks assessed investigate effects hypothyroidism cognition performance determined hypothyroidism triggers significant dysfunction learning memory processes observed morris water maze latency times higher ptu rats controls ptu cognitive impairment correlated reduction hippocampal plasticity respect long term potentiation ltp control ptu depression ltd control ptu furthermore decrease rate glucose utilization control nmol protein ptu nmol protein observed along increase oxidative stress decrease map marker hippocampus findings suggest induction hypothyroidism young rat model alters numerous functions level hippocampus published elsevier
objective superoxide dismutase sod omim one major antioxidant enzymes plays vital role clearance reactive oxygen species genetic polymorphism insertion deletion ins del promoter region sod reported aims present study evaluate influence polymorphism sod mrna levels human peripheral blood cells association risk heroin dependency methods present study consisted healthy students shiraz university south west iran investigating association ins del polymorphism expression level sod also total heroin dependent healthy controls included case control study investigating association study polymorphism risk dependency heroin quantitative sod mrna expression levels investigated using quantitative real time pcr results statistical analysis revealed significant difference study genotypes del allele study polymorphism decreased approximately sod mrna levels gene heterozygote individuals statistical analysis indicating genders neither ins del del del genotypes associated risk heroin addiction conclusions present study indicating although ins del polymorphism sod associated sod expression levels polymorphism associated risk dependency heroin
determining dimensions geosynthetic lining system important knowledge behaviour anchorage geotextile sheets order optimise geometry structures question reduce area taken anchorage anchorage solutions using trenches varying forms sometimes used paper focuses two types anchors simple run wrap around first author previously performed pull tests using anchorage bench controlled conditions using three types geosynthetics two types soil results obtained study showed optimum length upper part geosynthetic wrap around anchorage detailed analysis describes behaviour geosynthetic wrap around anchorage influence geosynthetic soil types presented herein
used data cambridge study delinquent development prospective longitudinal survey males united kingdom followed age age investigate intimate partner violence ipv association psychopathy investigated differences psychopathy scores men convicted violence involved extra intra familial violence committed ipv also considered whether generally violent men poorer life success overall regard drinking drug taking depression mental disorders findings suggest men violent within outside home generally violent men distinguished commit violent crimes outside home involved ipv within home differences appear degree kind findings discussed focus whether specific interventions required commit ipv whether early intervention focused violent behavior general
sensitivity analysis performed gain fundamental insights system behavior usually reproduced model identify relevant input variables whose variations affect system model functional response reliability analysis passive safety systems nuclear power plants npps models best estimate thermal hydraulic codes predict system functional response normal accidental conditions paper ensemble three alternative invariant methods innovatively set code input variables ensemble aggregates input variables raking orders provided pearson correlation ratio delta method beta method capability ensemble shown code passive containment cooling system pccs advanced pressurized water reactor loss coolant accident loca whose output probability density function pdf approximated finite mixture model fmm basis limited number simulations elsevier ltd rights reserved
aim adiponectin abundant adipokine may play key role interplay obesity inflammation insulin resistance metabolic syndrome mets thus large population based cohort investigated whether adiponectin baseline decrease adiponectin follow associated prospectively risk incident mets methods using prospective study design development mets examined healthy participants community plasma adiponectin measured study entry median follow years iqr follow participants developed mets presented least two components mets results follow adiponectin decreased participants developed mets whereas adiponectin increased develop mets low adiponectin levels quartile baseline increased risk developing mets compared high levels quartile adjusting confounding variables low adiponectin levels baseline remained independently associated mets similarly participants decrease adiponectin follow also increased risk mets association persisted multivariable adjustments including baseline adiponectin finally adiponectin levels follow inversely associated increase number components mets geometric mean adiponectin levels participants components four five components conclusions interpretation low plasma adiponectin levels baseline decreasing adiponectin levels follow associated increased risk mets elsevier masson sas rights reserved
three reliability based design optimization methods namely reliability index approach performance measure approach sequential optimization reliability assessment applied long span suspension bridge probabilistic flutter constraint uncertainties extreme wind velocity well flutter derivatives obtained wind tunnel considered rbdo problem presented research seeks minimize bridge girder weight varying thicknesses girder plate satisfying structural reliability level flutter order solve problem three rbdo methods mentioned programmed matlab code calls abaqus finite element models obtain structural responses flas code developed research group calculate flutter velocity proposed messina bridge used application example methods prior solve rbdo problem reliability analyses performed order obtain safety level original design results obtained different rbdo methods compared accuracy computational efficiency elsevier ltd rights reserved
inflammation driving force brain injury patients multiple sclerosis objective present study delineate serum cytokine profile patients progressive southern brazilian population compared healthy controls patients relapsing remitting rrms associations disease progression disability included patients progressive rrms healthy controls patients evaluated using expanded disability status scale edss magnetic resonance imaging mri gadolinium serum interleukin beta tumor necrosis factor tnf alpha interferon ifn gamma levels assessed using enzyme linked immunosorbent assay beta tnf alpha ifn gamma levels higher progressive controls increased beta ifn gamma decreased levels found progressive compared rrms patients progressive disease progression presented higher tnf alpha ifn gamma levels without disease progression patients progressive disease progression showed higher frequency positive gadolinium enhanced lesions mri higher tnf alpha ifn gamma levels decreased levels compared rrms patients progression significant inverse correlation levels edss score patients progressive results underscore complex cytokine network imbalance exhibited progressive patients show important involvement tnf alpha ifn gamma pathophysiology progression disease moreover serum levels inversely associated disability patients progressive
borderline personality disorder bpd regarded one difficult clinical presentations treat psychotherapy provides best outcomes suffering bpd dialectical behavioral therapy dbt schema focused therapy sft two common evidenced based treatments borderline pathology treatments often used individually theorists argue blended approaches care could provide benefit clients one treatment package alone present case study illustrates blended approach treatment bpd specifically dbt sft used consort treat luisa year old biracial woman caucasian hispanic descent struggled longstanding interpersonal distress emotional lability identity disturbance treatment course described detail implications approach care discussed
using two waves longitudinal data utilized family stress model economic hardship test whether family socioeconomic status related adolescent adjustment substance use academic achievement parental knowledge adolescent self regulation behavioral self control delay discounting participants included adolescent male bar age years wave bar age years wave primary caregiver dyads results structural equation modeling revealed significant three path mediation effects low family socioeconomic status wave associated low parental knowledge wave turn related low academic performance high substance use wave mediated low adolescent behavioral self control wave results illustrate parental knowledge influenced family economic status may play important role development adolescent behavioral self control adjustment
reconfigurable analog mixed signal ams platforms scaled cmos technology nodes gaining importance due increased design cost effort shrinking time tomarket similar field programmable gate arrays fpga digital designs programmable analog device array panda provides flexible versatile solution transistor level granularity reconfiguration capability rapid prototyping validation analog circuits paper presents design synthesis methodology panda design cmos technology consisting cell array reconfigurable interconnect configuration memory serial programming interface implement ams circuits panda platform paper proposes cad tool technology mapping placement routing configuration bit stream generation several representative building blocks ams circuits amplifiers voltage current references filters successfully implemented panda platform dynamic reconfiguration capability panda demonstrated input offset cancellation operational amplifier using fpga closed loop initial measurement results panda implemented circuits demonstrate potential methodology rapid prototyping hardware validation analog circuits
background sacroiliac joint spine seen abdominal computed tomography may show structural lesions part spondyloarthritis purpose determine prevalence features spondyloarthritis patients crohn disease material methods retrospective study structural lesions spondyloarthritis abdominal performed sacroiliac joints spine patients studied study group consisted patients known inflammatory back pain group involved patients without inflammatory back pain group iii consisted patients without known joint inflammatory bowel disease recorded features included sclerosis erosions ankylosis sacroiliac joint enthesopathy spinal syndesmophytes costovertebral joint lesions results showed structural lesions sacroiliac joints patients inflammatory back pain sclerosis erosions ankylosis patients without inflammatory back pain sclerosis erosions ankylosis patients without known joint bowel disease sclerosis ankylosis syndesmophytes exclusively seen group conclusion abdomen patients inflammatory back pain shows structural lesions sacroiliac joint entheses spine almost half patients awareness knowledge findings may guide referring clinician clinical evaluation imaging biomarker evaluation disease
digital signal processing techniques employed investigate joint use charge division risetime analyses resistive anode coupled microchannel plate detector mcp contrast typical approach using relative charge corner joint approach results significantly improved position resolution conventional charge division analysis utilizing analog signal processing provides measured position resolution fwhm using correlation risetime position able obtain measured resolution fwhm corresponding intrinsic resolution fwhm single stack mcp detector elsevier rights reserved
measurement programs large software development organizations contain large number indicators base derived measures monitor products processes projects diversity number measures causes measurement programs become large combining multiple needs measurement tools organizational goals measurement program effectively support organization goals scalable automated standardized flexible robust paper present method assessing robustness measurement programs method based robustness model developed collaboration seven companies university purpose method support companies optimize value obtained measurement programs cost evaluated method seven companies results applying method company quantified robustness programs reflecting real world status programs pinpointed strengths improvements programs elsevier inc rights reserved
project delivery system pds key means owner creates preconditions successful realization project thus worthwhile finding systems used different instances paper aims increase general knowledge area first introducing results analysis data forty thousand new building construction projects launched finland annual shares different pdss determined separately residential industrial business premises well buildings mainly public service buildings paper also sheds light changes market structure extent influence use different pdss order discover key factors could possibly hamper making conclusions general trends impact economic situation selection pds project results study shows separate contracts method used share construction management smallest house construction design build traditional comprehensive contract systems used whose shares fall two extremes changes market structure time likely influence use different pdss housing construction authors published elsevier
purpose aim study evaluate case control study esthetic functional clinical performance ceramic inlays used covering screw access hole single monolithic lithium disilicate full contour crowns bonded computer aided design computer aided manufacturing cad cam prefabricated titanium abutments order eliminate drawbacks alternative restorative methods materials methods twenty eight patients missing teeth lateral areas premolars molars received screw retained implant restorations half restorations composite fillings used seal access hole control group half sealed ceramic inlays test group determine restoration occlusal wear impressions obtained restorations finalized year years follow casts scanned scanner design system recording anatomical surfaces white model replicates wear amounts calculated maximum loss height occlusal surface clinical evaluation carried using kit specifically designed assessing fdi criteria statistics performed using analysis variance anova results total restorations delivered years follow wear values control group ceramic inlay group one way anova showed significant differences among vertical loss two groups clinical outcomes according fdi score assessing dental restorations revealed substantial deterioration within years follow conclusion use ceramic inlays appears predictable esthetic successful method sealing screw holes screw retained implant restorations
cmos charge amplifier due low power consumption good noise performance great interest analog signal processing fields particle physics nuclear physics beta ray detection simulation environment eldo using ami american microsystems inc technology provided mentor graphics corporation used noise optimization low power cmos charge amplifier using simulation tools designed simulated output charge amplifier calculated power consumption band width gain equivalent noise charge enc circuit also studied factors noise amplifier depends resulted noise performance enc electrons detector capacitance power consumption per channel due low noise low power consumption kind new charge amplifier widely used research fields particle physics nuclear physics ray detection
part circulating ghrelin bound immunoglobulins protecting degradation preserving functional activity review summarizes data ghrelin desacyl ghrelin reactive igg conditions altered appetite energy balance plasma levels affinity kinetics igg compared patients obesity anorexia nervosa animal models obesity including mice high fat diet induced obese mice obese zucker rats well mice chronic food restriction activity based anorexia rats methotrexate induced anorexia show plasmatic igg obese humans animals characterized increased affinity ghrelin contrast patients anorectic rodents show lower affinity ghrelin desacyl ghrelin reactive igg respectively changes observed non anorectic chronically starved mice also show affinity ghrelin reactive igg correlate plasma levels ghrelin data point common mechanisms underlying modifications affinity kinetics properties ghrelin reactive igg chronic alterations energy balance humans rodents support functional role autoantibodies ghrelin mediated regulation appetite
past decade salient object detection attracted lot interests computer vision although many models proposed detect salient object arbitrary image problem still plagued complex backgrounds scattered objects address issue paper explore information cross features via diversity induced multi view regularization hilbert schmidt independence criterion hsic based diversity term new matrix decomposition based model proposed salient object detection furthermore regularizer introduced constrain background part regularizer make background much cleaner saliency map group sparsity induced norm imposed salient part order involve potential spatial relationships image patches method solved augmented lagrange multipliers method high level priors also integrated boost performance experiments four widely used datasets show method outperforms state art models
background patients psoriatic arthritis psa experience functional impairment reduced quality life thus patient global assessment psa explained mainly physical also psychological aspect disease assess prevalence minimal disease activity mda spanish patients psa examined characteristics association mda impact disease assessed psa impact disease psaid questionnaire methods cross sectional multicenter study carried patients fulfilled classification psoriatic arthritis caspar criteria least year disease duration treated biological conventional synthetic disease modifying anti rheumatic drugs dmards according routine clinical practice spain patients considered mda met least mda criteria association mda recently developed psaid questionnaire also recorded results patients included mda state antitumor necrosis factor anti tnf monotherapy csdmard monotherapy anti tnf alpha combination csdmard using multivariate logistic regression analysis male gender odds ratio sedentary lifestyle familial history psa reactive protein crp level use corticoids considered features related mda mda patients significantly lower impact disease according psaid mean total score mda non mda conclusions nearly spanish psa patients achieve mda routine clinical practice mda remains one useful therapeutic targets psa since patients reached state also significantly lower impact disease according psaid
agricultural practices jiangnan water towns historically identified maintaining balance human activity local environment significant local source water pollution using multi methods approach study deduces environmental impact traditional practices socially desired conditions successfully reintroducing critical ones oral histories farmers tianshanzhuang village south yangtze river order chart changes farming practices four historic periods used estimate nitrogen phosphorus burdens per acre findings show use lan river muddredged mud fertilizerwas key producing positive impact abandoned four criteria hindering reintroduction traditional practices identified potentially useful fragmented emerging local candidate practices considered recent practices japan propose cooperation several stakeholders various related government departments china could lead portfolio effective policy changes studied include new methods uses lan river mud integration aquaculture leisure tourism industries agriculture production organic produce well planned internet linked sales delivery coordination mechanisms
present economic assessment impacts demand response pricing schemes conditions distributed solar photovoltaics focus individual households optimization model developed minimizes electricity cost individual households option dispatching loads appliances hydronic heating electrical water heating space heating hot water investigated well effects applying monthly hourly net metering pricing scheme selling excess generated electricity tax reduction scheme electricity sold grid show swedish conditions monthly net metering pricing scheme would result largest installations per household median rated capacity wpihousehold use tax reduction scheme reduces installation per household kwp household installation profitable larger fraction households furthermore tax reduction scheme retains incentive engaging use hydronic support installations sizes tax reduction scheme whilst appliance shown low impact profitability installation elsevier ltd rights reserved
property material essentially determined microstructure numerical models increasingly focus modern engineering helpful tools tailoring optimization custom designed microstructures suitable processing alloy design huge variety software tools available predict various microstructural aspects different materials general frame integrated computational materials engineering icme approach microstructure models provide link models operating atomistic electronic scales models operating macroscopic scale component processing view improved interoperability different tools highly desirable establish standardized nomenclature methodology exchange microstructure data scope article provide comprehensive system metadata descriptors description microstructure presented descriptors limited mere geometric description static microstructure complemented descriptors properties numerical representations kinetic data others future attributes descriptor data origin data uncertainty data validity range defined ongoing work proposed descriptors intended independent specific numerical representation descriptors defined article may serve first basis standardization simplify data exchange different numerical models well promote integration experimental data numerical models microstructures hdf template data file simple three phase microstructure based defined descriptors complements article graphics
children autism spectrum disorder asd experience internalizing externalizing problems higher rates typically developing children could worsen social impairment present study compared impairment scores social responsiveness scale edition srs scores children years male asd either without heightened levels anxiety adhd symptoms per parent report children heightened anxiety problems showed higher scores four srs subscales social cognition social communication social motivation restricted interests repetitive behavior children heightened adhd traits showed higher scores two subscales social communication social awareness findings suggest similarities differences social deficits asd may worsen anxiety adhd symptoms
science gateways provide scientists tools creating executing monitoring scientific experiments multiple resource infrastructures apache airavata abstracts interactions gateways distributed computing infrastructures like extreme science engineering discovery environment international grids campus clusters airavata consists several component services api server orchestrator workflow interpreter credential store application factory addition airavata uses third party software including rabbbitmq messaging mysql production database management apache zookeeper internal communications paper discuss initial experiences leveraging open source technologies manage airavata dependent components deploy detect restart failed components auto scaling platform capabilities allow airavata services deployed wide area large virtual machine based cluster developer laptop emerging technologies cloud computing big data address needs following docker marathon apache mesos docker linux based lightweight container allows different applications run isolated safely share machine resources docker images applications published registries retrieved execution target infrastructures marathon provides cluster wide init control system services including docker containers mesos provides cluster wide framework schedule tasks based fine grained resource needs mesosphere provides packages scripts web interface ease use technologies present design experience lessons learned integrating mesos docker marathon apache airavata copyright john wiley sons ltd
study uses qualitative analysis semi structured interviews explore adjustment challenges encountered international graduate students study universities protective factors associated successful adjustment nine students china korea taiwan attending midwestern university participated study language barriers discrimination primary challenges reported factors associated successful adjustment personal perception social support strong mentoring relationships religious belief use campus services implications providing effective assistance international graduate students discussed
objective retention hiv care particularly among postpartum women challenge national antiretroviral therapy programs retention estimates may underestimated unreported transfers explored mobility clinic switching among patients considered lost follow ltfu design observational cohort study methods women initiating antiretroviral therapy pregnancy public clinics johannesburg south africa ltfu visit months manually searched women south african national health laboratory services database assess continuity hiv care used geographic information system tools map mobility new facilities results one third women showed evidence continued hiv care ltfu continued care province origin clinic compared traveled outside province care province clinic shoppers stayed care longer median days interquartile range iqr days iqr lower cell count entry median cells iqr cells iqr considering women additional evidence care engaged care cohort ltfu dropped conclusions found evidence continued care ltfu identified local national clinic mobility among postpartum women laboratory records show clinic visits manual matching may overestimated national health database linked unique identifier necessary improve reporting patient care among highly mobile populations
nursing history comes impetus grounding current voice gender trans dialogue modern nursing struggled way restrictive unjust oppressive social structures many obstructions constraints nurses nursing leaders faced shared general populace women yet nurses different women nurses worked outside home caring strangers including unrelated men period women otherwise confined home nurses fought women suffrage child labor laws welfare factory workers garment workers unionization vaccination housing reform humane treatment mentally ill persons access birth control amelioration panoramic terrain terrible social injustices control nursing education registration practice years nursing intrinsically practically politically feminist hard fought gains would eventually position nursing tension emerging trans issues yet history exactly situates nursing fruitful participation developing trans discourse address issues transinvisibility unjust social health structures impede dignified respectful health care
complement activation major importance numerous pathological conditions therefore targeted complement inhibition promising therapeutic strategy esterase inhibitor inh controls activation classical pathway lectin pathway however conflicting data exist inhibition alternative pathway inh inhibitory capacity inh potentiated heparin glycosaminoglycans data exist current study investigates effects inh presence absence different clinically used heparinoids furthermore combined effects heparinoids inh coagulation investigated inh heparinoids combinations analysed dosedependent fashion presence pooled serum functional complement activities measured simultaneously using wielisa kit activated partial thrombin time determined using automated coagulation analyser results showed three complement pathways inhibited significantly inh heparinoids next individual effects complement activation heparinoids also enhanced inhibitory capacity inh significantly significant potentiation inh heparinoids found however restricted certain concentration ranges low concentrations effect blood coagulation combining heparinoids inh minimal conclusion study shows significant potentiating effects heparinoids inhibition complement pathways inh therefore combined use promising potentially cost effective treatment option complement mediated diseases
smoking potential risk factor age related cognitive decline date study examined association smoking cognitive decline men living human immunodeficiency virus hiv aim present study examine whether smoking status severity midlife associated rate decline cognitive processing speed among older hiv seropositive hiv seronegative men sex men data older hiv seropositive hiv seronegative men sex men multicenter aids cohort study examined participants information smoking history collected age years least years follow age smoking history categorized never smoker former smoker current smoker cumulative pack years calculated raw scores three neuropsychological tests trail making trail making symbol digit modalities tests log transformed trail making used linear mixed models determine associations smoking history least subsequent year decline cognitive processing speed significant differences rates neurological decline among never smokers former smokers current smokers findings similar among hiv seropositive participants however increase pack years statistically significantly associated greater rate decline trail making test score composite score beta respectively found significant association smoking treated categorical variable never smoked former smoker current smoker small change every increase pack years measures psychomotor speed cognitive flexibility optimize healthy aging interventions smoking cessation tailored men sex men
musculoskeletal manifestations child maltreatment represent common presentations emergency department recognition child maltreatment essential role practicing emergency physician directly prevent serious injury orthopedic trauma children presents differently adults understanding unique properties pediatric bone well developmental capabilities children relation injury mechanism essential interpretation injuries children younger years vulnerable bony injury child maltreatment common presenting findings include complex skull fractures rib fractures long bone fractures metaphyseal corner fractures skeletal survey remains mainstay detection injuries recent work also elucidated role modalities fracture detection management include proper orthopedic interventions along mandatory reporting possible maltreatment local child protective services equivalent agency
gratitude promotes well prompts prosocial behavior examine novel way cultivate beneficial emotion demonstrate different types consumption material consumption buying sake experiential consumption buying sake differentially foster gratitude giving studies show reflecting experiential purchases travel meals tickets events inspires gratitude reflecting material purchases clothing jewelry furniture thinking experiences leads subsequent altruistic behavior thinking possessions studies use within subject subjects designs test main hypothesis people grateful done study finds evidence effect real world setting online customer reviews consumers likely spontaneously mention feeling grateful experiences bought material goods bought final studies show experiential consumption also makes people likely generous others participants contemplated significant experiential purchase behaved generously toward anonymous others economic game contemplated significant material purchase thus appears shifting spending toward experiential consumption improve people everyday lives well lives around
background influenza infection result severe disease debilitating complications young children highest rate influenza hospitalisations various factors influencing influenza susceptibility severity objectives study aimed determine disease burden assess risk factors severe hospitalised influenza south australian children years age methods influenza admissions tertiary paediatric hospital south australia identified data laboratory confirmed influenza cases collected including infecting influenza strain infections prematurity pre existing medical comorbidities potential risk factors predictors high level care assessed using logistic regression results total children laboratory confirmed influenza hospitalised admissions occurred children without underlying medical risk factors eighteen children required high level care underlying medical risk factors deaths reported majority children unimmunised influenza infections identified children influenza associated requirement higher care history food allergies iron deficiency anaemia conclusions influenza severe illness even children without underlying medical conditions identification influenza strain history food allergies iron deficiency anaemia predictors severity hospitalised cases warrants investigation may important implications preventative strategies reduce burden childhood influenza
background syndrome transient headache neurologic deficits cerebrospinal fluid lymphocytosis handl self limited benign disorder unclear pathogenesis diverse clinical manifestations cases report two unusual presentations entity first case developed catastrophic picture characterized acute elevation intracranial pressure necessitating emergency life support second case presented hyperacute onset mixed aphasia facial droop masquerading acute ischemia middle cerebral artery territory patients made full recoveries conclusion possibility handl considered individuals presenting unusual patterns headaches transient neurological symptoms report expand spectrum disorder help physicians recognize unusual manifestations rare disorder also consider potential therapeutic interventions
background aims thyroid disease common comorbidity individuals syndrome historical studies multiple limitations assessed thyroid abnormalities large cohort children methods retrospective records review single institution calculated prevalence common thyroid abnormalities associations common comorbidities results among patients thyroid related diagnosis majority elevated thyrotropin treated levothyroxine kaplan meier estimate projects thyroid disorder adulthood hypothyroidism diagnosed age months tested approximately positive antithyroid antibodies though rate overt hypothyroidism association congenital acquired hypothyroidism common comorbidities conclusion thyroid disease common occurs earlier general population often transient thyroid disease unrelated gender obesity comorbidities apart overt hypothyroidism much hypothyroidism appears unrelated autoimmunity recommend checking antithyroid antibodies select cases additional screen thyroid disease newborn screen month well child visit detect early cases hypothyroidism passed newborn screen karger basel
electrical instrumentation control systems eics built documentations copper mine found possess significant errors omissions hindered asset owner ability undertake effective efficient operations maintenance systems information model sim used retrospectively create connected system ensure physical equipment associated connections constructed modelled object orientated database creating sim existing errors omissions built documentation quantified cost savings could achieved future planned copper mine similar design identified limitations using conventional computer aided design cad design document eics discussed recommended retrospectively creating sim provide owners operators significant productivity benefits well ensure asset integrity case study presented provides asset owners operators empirical evidence challenge conventional thinking surrounding design engineering documentation eics using cad alternatively consider use sim elsevier ltd rights reserved
knowledge coproduction practitioners scientists offers promising opportunities emerging research field geography sustainability transitions drawing experiences international research project urban green building transitions article explores potentials challenges interactive collaborative knowledge generation methods understanding sustainability transitions results show ongoing engagement local experts practitioners interactive world cafe workshops follow exchanges allows better understanding research context knowledge exchange participants involved research process
analyze popularization obstacles lcc technology green building put forward lcc technology modular promotion mechanism based percolation theory paper builds permeability model lcc technology application propose generation rules lcc module combined lcc technical process principle module partition decompose lcc process form lcc module build lcc technology expert system research aims promote popularization application lcc technology green building
background taxanes anthracyclines considered fundamental drugs treatment broad range cancers several side effects may limit usage drug induced nail pigmentation dhnp reported one striking dermatological side effect taxanes doxorubicin objective study aimed evaluate compare pigmentary side effects taxanes doxorubicin help onychoscopy methods forty one consecutive patients women men diagnosis cancer gastric cancer breast cancer prospectively enrolled period six months patients categorized according chemotherapy regimens administered docetaxel received group docetaxel day cisplatin day fluorouracil days every weeks paclitaxel received group paclitaxel every days without trastuzumab zoledronic acid doxorubicin received group doxorubicin cyclophosphamide every days patients asked whether diabetes mellitus peripheral neuropathy weeks chemotherapy patient fingernails toenails evaluated clinical dermoscopic examinations nail pigmentation dermoscopic examination performed using videodermatoscope descriptive statistics computed means standard deviations frequencies chi square test fisher exact tests used statistical analysis significance threshold results patients demonstrated clinical signs nail pigmentation nail pigmentation observed patients received doxorubicin patients received taxanes docetaxel paclitaxel statistically significant relationship nail pigmentation type chemotherapeutic regimen administered fisher exact test addition statistically significant results observed nail pigmentation fisher exact test nail pigmentation peripheral neuropathy fisher exact test conclusions dhnp may cause considerable distress patients dermoscopy noninvasive imaging method increases diagnostic accuracy pigmented nonpigmented lesions typical dermoscopic features dhnp consist homogeneous brownish gray coloration background thin longitudinal gray lines allow examiner clearly make correct diagnosis studies needed assess clinical dermoscopical findings dhnp
paper presents development mobile application android systems devices helps control system design task application allows compute parameters pid type controllers controlled process represented first second order plus dead time model application tunes dof degree freedom pid controllers servo regulatory control operation dof pid controllers using methods presented alfaro vilanova shown use application tool possible evaluate benefits control systems undergraduate students taking account spread use pid controllers industrial applications important engineering undergraduate students get necessary skills handle kind control problems sense developed tool helps teaching learning process achieve knowledge tool used significant quantity students receiving positive feedback
paper autonomous hybrid power system consisting wind turbine generator wtg dieselengine generator deg fuel cell aqua electrolyzer studied deg acts slack generator whose output power controlled real power balance system keep frequency deviation within limit paper proposes new control scheme incorporating pid controllers control output power deg keep real power frequency balance system pid controller introduced make frequency deviation zero steady state disturbance controller incorporated damp oscillations system frequency disturbance detail analysis effect pid controllers system mode presented using participation factor sensitivity system modes variation controller parameters investigated simulated responses isolated operation presented show proposed control strategy capable maintaining power frequency balance system following disturbance mathematical model interconnected system developed one feedback loop added existing pid controller area reduce tie line power loss grid connected distribution system connected operation hybrid power system also investigated elsevier ltd rights reserved
purpose aim prospective study compare non asian subjects pharmacokinetics pharmacodynamics safety tolerability two short acting cardioselective beta adrenergic antagonists landiolol esmolol administration three different bolus dosages materials methods conducted single center prospective double blinded randomized study three cross periods healthy subjects women men mean age years receiving three doses landiolol either newly developed concentrate formulation rapibloca concentrate lyophilized formulation three doses esmolol formulation brevibloca parameters safety tolerability assessed findings results two landiolol formulations reported previously similar landiolol concentrate formulation esmolol maximum blood concentrations rapidly reached mean max ranged min landiolol min esmolol parent drugs disappeared fast blood stream minutes minutes low doses landiolol esmolol respectively despite comparable injection rates landiolol esmolol respectively onset significant heart rate reduction occurred earlier response landiolol min response esmolol min addition significantly lower heart rate values obtained every dose level landiolol comparison esmolol compounds reduced systolic blood pressure comparable degree especially highest dose duration blood pressure reduction longer esmolol compared landiolol seven mild moderate adverse events occurred administration landiolol five occurred administration esmolol serious adverse events reported study
aging associated increase circulating inflammatory factors one cytokine stromal cell derived factor sdf cxcl critical stem cell mobilization migration homing well bone marrow stem cell bmsc osteoblast osteoclast function sdf pleiotropic roles bone formation bmsc differentiation osteoblasts osteocytes osteoprogenitor cell survival objective study examine association plasma sdf participants cardiovascular health study chs bone mineral density bmd body composition incident hip fractures chs participants sdf plasma levels significantly associated increasing age male gender race multivariable adjusted models higher sdf levels associated lower total hip bmd however significant association sdf hip fractures summary circulating plasma levels sdf associated increasing age independently associated lower total hip bmd men women findings suggest sdf levels linked bone homeostasis
study new structural identification method proposed simultaneously evaluate parameter partial external excitation external excitation decomposed linear combination orthogonal bases problem time variant excitation identification transformed identification constant decomposition coefficients new constrained unscented kalman filter ukf proposed identify structural parameters coefficients excitation decomposition based measurement acceleration response proposed filter retain physical meaning structural parameters identified three storey hysteretic nonlinear shear building investigated numerically structural parameter external force accurately identified proposed filter results simulation studies using constrained ukf compared conventional ukf shown parameters identified conventional ukf may lose physical meaning proposed constrained ukf retain physical meaning presence measurement noise structural parameters dynamic load still accurately identified using proposed constrained ukf indicates stability identification process
objective early victimization elevates children risk developing psychopathology recent findings suggest disruptions developmental processes related symptoms posttraumatic stress pts may partially account association early victimization subsequent psychopathology present study prospectively tested temporal sequencing associations using multiinformant measurements large diverse sample children high risk victimization method study measured victimization direct indirect familial nonfamilial violence pts externalizing internalizing problems among children girls boys participated longitudinal studies child abuse neglect longscan results structural equation modeling revealed addition directly impacting psychopathology childhood victimization contributed escalations internalizing externalizing problems children transitioned middle late childhood indirectly pts mediational role pts largely similar girls boys investigated early reports maltreatment identified early risk victimization conclusions study delineated role pts development psychopathology following early victimization findings highlight importance carefully assessing underlying trauma symptoms considering diverse presentations psychopathology among youth victimized
present paper examines use natural gas small four stroke engine internal combustion used movement small alternative generator electrical generator functioned without load different loads using fuels gasoline natural gas tests observed emissions every fuel load condition use natural gas fuel result emissions decrease different load flow natural gas regulated load behavior engine aspect efficiency gasoline means engine rpm every electrical load fuels gasoline natural gas tests consumption gasoline natural gas recorded noticed increased electrical load increased far consumption natural gas concerned noticed gives behavior engine aspect power engine rpm manufacturer gives use gasoline
fully automate regulatory compliance checking construction projects regulatory requirements need automatically extracted various construction regulatory documents transformed formalized format enables automated reasoning address need authors propose approach automatically extracting information construction regulatory textual documents transforming logic clauses could directly used automated reasoning paper focuses presenting proposed information transformation itr methodology corresponding algorithms proposed itr methodology utilizes rule based semantic natural language processing nlp approach set semantic mapping sem rules conflict resolution cor rules used enable automation transformation process several syntactic text features captured using nlp techniques semantic text features captured using ontology used sem cor rules bottom method leveraged handle complex sentence components consume generate mechanism proposed implement bottom method execute sem rules proposed itr algorithms tested transforming information instances quantitative requirements automatically extracted international building code logic clauses algorithms achieved precision recall respectively testing data american society civil engineers
background linked lymphoproliferative disease type xlp caused mutations shda gene characterized mainly hypogammaglobulinemia abnormal response epstein barr virus high predisposition cell non hodgkin lymphoma development observations article describe experience centers belarus russia follow male patients diagnosed xlp lymphoma development treatment three novel mutations insa kkfsx found males patients xlp two signs immunodeficiency cell non hodgkin lymphoma development conclusions propose shda mutational screening considered male patients without hypogammaglobulinemia received rituximab treatment lymphoma recover immunoglobulin year depleting therapy
study introduces automatic classification system uses electroacoustic analyzer measure frequency response earphones system designed using pro package improved via testing system controller used study microchip picf microcontroller controller connected electroacoustic analyzer various motor drives control process classification system divided two parts first part placement earpiece matrix tray two electric tables linear rail adopted build two axis table device introduced onto table moves earpiece correct point drops matrix tray second part classification mechanism according results frequency response earpieces organized eight classes receiving classification results frequency response measuring device controller plot shortest path moving earpiece thereafter specified class number recovered coordinates table reset study proposes establish automatic classification system earphones earpiece appropriately dropped correct position within classified matrix tray frequency response classification complete message forwarded controller
heterogeneous parallel distributed computing systems frequently must operate environments uncertainty system parameters robustness defined degree system function correctly presence parameter values different assumed environment execution time given task may fluctuate substantially due factors content data processed determining resource allocation robust uncertainty important area research study define stochastic robustness measure facilitate resource allocation decisions dynamic environment tasks subject individual hard deadlines task requires input data start execution environment tasks meet deadlines dropped discarded define methods determine stochastic completion times tasks presence task dropping stochastic task completion time used definition stochastic robustness measure based stochastic robustness measure design novel resource allocation techniques work immediate batch modes goal maximizing number tasks meet individual deadlines compare performance technique several well known approaches taken literature adapted environment simulation results study demonstrate suitability new technique dynamic heterogeneous computing system elsevier inc rights reserved
study aims investigate year hand bone loss hbl year early rheumatoid arthritis patients treated methotrexate mtx intra articular triamcinolone treat target strategy adalimumab determine hblmonths associated radiographic progression years clinical trial opera treatment naive early patients bone mineral density bmd estimated hand radiographs digital ray radiogrammetry dxr baseline months follow baseline year radiographs scored according sharp van der heijde method baseline characteristics hblmonths months changes dxr bmd investigated predictors structural damage univariate linear dagger total sharp van der heijde score tss dependent variable logistic radiographic progression dagger tss dependent variable regression analyses variables early patients treated methotrexate based treat target strategy majority patients increased hbl year irrespective adalimumab hblmonths independently associated dagger tss years
sarcopenia prevalent patients distal radius fracture drf age sex matched controls lower appendicular mass index men weaker grip strength men women increase likelihood drf introduction sarcopenia core component physical frailty predisposes older people falls negatively impacts activities daily living objectives study compare prevalence sarcopenia patients drf age sex matched controls without drf evaluate association sarcopenia occurrence drf methods prospectively recruited patients years age sustained drf due fall age sex matched controls without drf definition sarcopenia based consensus asian working group sarcopenia sarcopenic components including appendicular lean body mass grip strength gait speed compared two groups factors assessed occurrence drf age gender body mass index bmi lumbar hip bone mineral density bmd values conditional logistic regression analysis conducted evaluate associations sarcopenia occurrence drf results total drf patients sarcopenic whereas controls within sarcopenic criteria patient group significantly lower lean body mass weaker grip strength control group however significant difference gait speed two groups according regression analysis lower appendicular mass index men associated increased incidence drf odds ratio confidence interval weaker grip strength lower total hip bmd values associated occurrence drf men respectively women respectively conclusions sarcopenia prevalent patients drf age sex matched controls lower appendicular mass men weaker grip strength lower hip bmd men women increase likelihood drf
recursions quite important mathematical tools since many systems mathematically modelled ultimately take equations rather easy algebraic natures fit computer programming needs quite well many circumstances produce solutions however generally desired find asymptotic behaviour general term relevant sequence convergence therefore practicality issues one general tendencies find general term asymptotic behaviour ordering number grows unboundedly integral representation generating function depend individual sequence elements tried done almost types recursions even though linear cases gain importance others effectively investigated using many linear algebraic tools despite may seem somehow rather trivial lot theoretical fine tuning issues construction true integral representations true intervals real axis paths complex domains work devoted focus issue starting scratch better understanding matter example cases chosen best illuminate situations get information future generalization even though work considered somehow introductory level
viewpoint outlines likely impact election republican government donald trump president children youth families focuses primarily impact undocumented mixed status families briefly addresses impacts children health services juvenile justice education
background age related sarcopenia cause various forms physical disabilities investigated sarcopenia affects degenerative lumbar scoliosis dls lumbar spinal canal stenosis lscs methods subjects comprised elderly women mean age years spinal disease whose chief complaints low back pain lower limb pain included cases dls mean years cases lscs mean age years performed whole body dual energy ray absorptiometry dxa analyze body composition including appendicular trunk skeletal muscle mass index smi lean mass height bone mineral density bmd diagnostic criterion sarcopenia appendicular smi degrees sagittal vertical axis sva sarcopenia prevalence correlations spinal alignment bmd clinical symptoms appendicular trunk smis correlation spinal alignment clinical symptoms investigated results dls cases significantly lower body weight bmi lean mass arm total lean mass lscs cases sarcopenia prevalence rates cases lscs cases dls revealing high prevalence dls appendicular smis dls lscs trunk smis dls lscs showing dls significantly lower values lscs spinal alignment correlations revealed appendicular smi negatively correlated trunk smi found significant negative correlation sva vra trunk smi found significant positive correlation bmd clinical symptoms rdq negatively correlated appendicular smi positively correlated conclusions sarcopenia complications noted lscs patients much higher percentage dls patients appendicular trunk smis lower dls suggesting sarcopenia may involved scoliosis appendicular skeletal muscle related posterior pelvic tilt trunk muscle affected stooped posture posterior pelvic tilt lumbar scoliosis vertebral rotation decreases trunk muscle mass also associated osteoporosis moreover rdq negative correlation appendicular skeletal muscle mass positive correlation suggesting sarcopenia may associated low back pain result posterior pelvic tilt research reveals first time sarcopenia involved spinal deformations suggesting decreases pelvic lumbar support structures trunk appendicular muscle mass may involved progression spinal deformities increased low back pain
aim study compare clinical manifestations disease activity functional capacity spinal mobility radiological findings men women multicenter multiethnic ibero american cohort patients spondyloarthritis spa observational cross section study included consecutive spa patients fulfilled modified new york criteria ankylosing spondylitis demographic clinical radiologic data evaluated categorical data compared chi fisher exact tests continuous variables anova post hoc tests primary diagnosed patients psoriatic spondylitis spondylitis associated inflammatory bowel disease ibd patients overall male patients significantly younger longer diagnostic delay lower disease activity worse spinal mobility better quality life severe radiologic damage dactylitis enthesitis well swollen joint count significantly common among women primary marked male predominance among patients psoriatic spondylitis male predominance lower also associated worse spinal mobility severe radiologic damage total population male patients primary referred higher permanent work disability although difference observed psoriatic ibd spondylitis according gender among ibero american spa patients differences clinical radiological manifestations men showing structural damage whereas women active disease data suggest phenotype spa differs genders influence subsequent diagnostic approach therapeutic decisions
background family sequence similarity member fama variants associated susceptibility chronic lung diseases recent genome wide association study shown association polymorphism fama idiopathic interstitial pneumonias caucasian population however relationship polymorphism prognosis idiopathic interstitial pneumonias investigated methods sixty five patients idiopathic pulmonary fibrosis ipf japanese healthy volunteers enrolled study genomic dna extracted subjects genotyped commercially available assay correlations polymorphism survival occurrence acute exacerbation evaluated results frequency minor allele significantly higher ipf patients controls major allele associated lower diffusing capacity carbon monoxide values higher composite physiologic index adjustment age sex smoking respectively kaplan meier analysis allele carriers showed significantly increased mortality compared non carriers multivariate cox proportional hazards analysis allele independently associated poor survival hazard ratio confidence interval conclusions fama gene polymorphism showed significant association susceptibility ipf severity lung function impairment poor prognosis elsevier ltd rights reserved
important applications platinum alloys related platinum group metals phases complete phase diagrams systems important materials engineering currently accepted phase diagram system questionable disagreement earlier experiments claim lone ordered structure characterized contradicts computational predictions analogy isoelectronic system complete examination system computational experimental means suggests phase diagram similar isoelectronic system unknown compound claimed found structure acta materialia inc published elsevier ltd rights reserved
shallow water wave equation increasing use many applications success eliminating spurious oscillation widely studied paper investigate dimensional generalized shallow water equation system based expansion method variable separation method choose epsilon suppose undetermined function instead constant different previous literatures aid symbolic computation obtain family exact solutions dimensional generalized shallow water equation system forms hyperbolic functions trigonometric functions parameters take special values addition traveling wave solutions also get nontraveling wave solutions using method obtained solutions possess abundant structures figures corresponding solutions illustrated show particular localized excitations interactions two solitary waves expansion method general powerful tool lead insights improvements nonlinear models
mobile devices widely used uploading downloading media files audio video images remote servers devices limited resources required offload resource consuming media processing tasks clouds processing migration tasks means media services provided clouds need authentic trusted mobile users existing schemes secure exchange media files mobile devices clouds limitations terms memory support processing load battery power data size schemes lack support large sized video files suitable resource constrained mobile devices paper proposes secure lightweight robust efficient scheme data exchange mobile users media clouds proposed scheme considers high efficiency video coding hevc intra encoded video streams unsliced mode source data hiding proposed scheme aims support real time processing power saving constraint mind advanced encryption standard aes used base encryption technique proposed scheme simulation results dearly show proposed scheme outperforms aes decreasing processing time increasing data size approximately proposed scheme readily applied real time cloud media streaming elsevier inc rights reserved
use biomarkers bms accurate diagnosis alzheimer disease proposed recent diagnostic criteria however maturity sufficient grant implementation clinical routine proper diagnostic process requires confirmation disease also exclusion similar disorders entering differential diagnosis like dementia lewy bodies dlb review aimed evaluating clinical validity ioflupane brain single photon emission tomography mibg cardiac scintigraphy imaging bms dlb purpose used adapted version phase oncology framework bms development review literature conducted using homogenous search criteria bms addressed parallel reviews results literature search showed rationale use bms differential diagnosis dlb strong phase allow good discrimination ability phase studies investigating bms distribution antemortem postmortem pathology lacking moreover thresholds test positivity defined mibg bms yet assessed early phases dlb phase phase phase studies far carried review highlights priorities address future investigations enable proper use ioflupane mibg differential diagnosis dementia elsevier inc rights reserved
present research vibration instability analysis viscoelastic shaped single walled carbon nanotube conveying fluid carried surrounding viscoelastic medium simulated various models kelvin voigt maxwell standard linear solid reissner nonlocal models size effects considered based modified couple stress theory order achieve accurate results fourth order beam theory utilized surface stress effects considered based gurtin murdoch theory addition effects asymmetry shaped single walled carbon nanotube also taken account regarding fluid structure interaction equations motion well boundary conditions derived using hamilton principle solved means hybrid analytical numerical method regarding temperature changes visco pasternak foundation effects different surrounding medium models discussed detail overall results indicated stability vibration characteristics shaped single walled carbon nanotube conveying fluid strongly dependent damping coefficient results work hoped useful design manufacturing nanodevices shaped nanotubes act basic element
due increase number internet users electronic commerce grown significantly last decade electronic auction auction one famous commerce applications even security robustness auction schemes still remain challenge requirements like anonymity privacy bid value threat attackers auction protocol must leak anonymity privacy bid value honest bidder keeping requirements mind firstly proposed controlled traceable blind signature scheme ctbss auction schemes able trace bidders using ctbss blind sealed bid electronic auction scheme proposed bsea incorporated notion blind signature auction schemes moreover schemes based upon elliptic curve cryptography ecc provides similar level security comparatively smaller key size discrete logarithm problem dlp based auction protocols analysis shows bsea fulfills requirements auction protocol total computation overhead lower existing schemes
paper analyzes specialties satellite radio communication systems discusses basic elements frequency spectrum management analyzes familiar types produced cause interference well reducing measures satellite communication systems puts forward calculation means electromagnetism interference gives kind spectrum management model based emc
paper presents systematic review effectiveness prevention early intervention harm reduction including treatment substance abuse among adolescents tobacco alcohol illicit drugs taxation public consumption bans restriction advertisements minimum legal age consumption effective measures reduce use tobacco alcohol school based prevention skill training interventions effective tools reduce substance use among adolescents social norms intervention reduce substance use adolescents strong evidence effectiveness road side testing reduction injection related harm effective however research needed support moreover available research evidence comes western countries questionable applicability indian setting research needed increase evidence base interventions aim reduce high burden substance use adolescents india
texture analysis major task many areas computer vision pattern recognition including biological imaging indeed visual textures exploited distinguish specific tissues cells biological sample highlight chemical reactions molecules well detect subcellular patterns evidence certain pathologies makes automated texture analysis fundamental many applications biomedicine accurate detection grading multiple types cancer differential diagnosis autoimmune diseases study physiological processes due specific characteristics challenges design texture analysis systems biological images attracted ever growing attention last years paper perform critical review important topic first provide general definition texture analysis discuss role context bioimaging examples applications recent literature review main approaches automated texture analysis special attention methods feature extraction encoding successfully applied microscopy images cells tissues aim provide overview state art well glimpse latest future trends research area authors published elsevier
prior studies identified key factors influence recycling intention however studies rarely pay attention interaction attitude subjective norm influences recycling intention study applied conceptual model extending theory planned behavior tpb addressing gap study collected responses street survey hong kong findings revealed two interaction terms experiential attitude subjective norm instrumental attitude subjective norm influenced recycling intention implies subjective norm plays crucial role motivating recycling behaviors moreover subjective norm could increase likelihood recycling people exhibiting positive experiential attitude motivate people possess limited knowledge recycling benefits practicing recycling behaviors policy implications drawn findings limitations study future research direction also discussed elsevier ltd rights reserved
report vestibular prosthesis signal processor realized using experimental field programmable analog array fpaa completing signal processing functions analog domain processor designed help replace malfunctioning inner ear sensory organ semicircular canal relying angular head motion detected inertial sensor signal processor maps angular velocity meaningful control signals drive current stimulator demonstrate biphasic pulse control omega resistive load placed across bridge circuit connected supply biphasic current maintained stimulation frequencies pulsewidths sec interphase gaps ranging sec
new method obtaining strong boxes based chaotic map teaching learning based optimization tlbo presented paper method presents eight rounds round contains two transformations row left shifting columnwise rotation vectors transformations different one round another controlled two keys logistic map two keys optimized using tlbo aims construct strong box satisfies criteria set advance test following criteria bijectivity nonlinearity strict avalanche criteria equiprobable inputs outputs xor distribution analyzed additionally provide many comparisons boxes test sensitivity keys results performance test show proposed design boxes presents good cryptography proprieties resist several attacks
objective systematic review aims identify evaluate literature investigating protective factors eating disorders eds establish known factors family systems could considered protective development disordered eating methods systematic review literature conducted five databases using search terms related disordered eating protective factors studies systematically screened included made reference protective factor within family system explored associations quantitative measure disordered eating behaviours included studies evaluated study quality results twenty five studies met criteria inclusion ten papers made use longitudinal prospective designs appropriate identify factors potentially protecting development disordered eating difficulties papers report cross sectional associations family factors disordered eating outcomes studies looked aspects family relationships family practices around food eating particular research focus potential protective role regular family meals conclusions implications many potential protective factors identified family support connectedness may non specific eating difficulties promoting general adaptive development range positive development outcomes factors family environment around food eating weight frequent family meals avoiding comments weight may specific disordered eating issues methodologies used severely impact ability draw conclusions whether factors protective
background randomized clinical trials showed improved overall survival advanced gastroesophageal adenocarcinoma gea patients treated second line taxane irinotecan however data irinotecan efficacy setting come large asian trials retrospectively analyzed clinical effectiveness toxicity irinotecan cohort patients advanced gea treated department methods advanced gea patients received least one cycle second line irinotecan eligible inclusion irinotecan administered every weeks initial dose body surface area subsequent gradual every dose escalation case good treatment tolerance estimated using kaplan meier method multivariate cox regression analysis used examine association clinical laboratory parameters survival results total patients identified median months confidence interval multivariate analysis age years baseline total lymphocyte count tlc presence peritoneal metastases associated shorter adverse events grade included anemia leukocytopenia neutropenia nausea vomiting diarrhea anorexia fatigue febrile neutropenia occurred three patients nine patients experienced toxicity grade kind conclusions retrospective analysis confirms clinical effectiveness manageable toxicity second line irinotecan unselected cohort advanced gea patients age years baseline tlc presence peritoneal metastases independent prognostic factors associated shorter
light potent stimulus regulating circadian neuroendocrine neurobehavioural responses humans light therapy effective treating select affective circadian sleep disorders past decade discoveries show biological behavioural effects light mediated newly discovered photoreceptor eye distinct classical rods cones vision findings providing basis major changes lighting advanced habitats space exploration well everyday buildings earth
study uses conjuring investigate effects suggestion social influence paranormal belief upon accuracy eyewitness testimony ostensibly paranormal event participants watched video alleged psychic seemingly bending metal key power psychokinesis half participants heard fake psychic suggest key continued bend put table half additionally participants exposed either negative social influence stooge witness reporting key continue bend social influence positive social influence stooge witness reporting key continue bend participants exposed verbal suggestion significantly likely report key continued bend additionally participants reported key continued bend positive social influence condition compared two social influence conditions finally believers paranormal likely report key continued bend non believers
today economic globalization cultural creative industries boomingly became one promising industries great growing potential recognized internationally twenty first century achieve enormous economic benefits social benefits although many scholars matter domestic abroad undertake discussing different point view still many problems shortcomings especially areas around beijing tianjin hubei province cultural creative industry also ignore problems solved urgently
parallel development nucleotide sequencing equally important interest describing sequence terms function arose latter represents current bottleneck overall research question sequencing transcriptome allows determination expressed nucleotide sequences using mass spectrometry allows sequencing protein level approaches sequence subset existing transcripts moreover example post translational modification events determined proteomics level therefore essential combine proteomics genomics purpose proteogenomics data analysis pipelines described describe novel proteogenomics workflow encompasses everything acquisition data result visualization konstanz information miner knime state art workflow management data analytics platform amended knime number processes like peptide consensus prediction peptide mapping database equalizing well result visualization enabled construction new workflow entitled pgminer includes data analysis steps highly customizable rather cumbersome existing pipelines furthermore burdensome installation processes performed making pgminer user friendly tool available elsevier inc rights reserved
minimal research explores impact dementia dementia diagnosis families unique vantage senior health professionals participants study eight senior aged care professionals provided unique interpretative insights family dynamics sense making journey dementia role journey positive negative perspectives sought data semi structured interviews analysed using interpretative phenomenological analysis ipa one superordinate theme dementia naivete redefined intimacy overarched embarrassed shame maintaining hope redefining model intimacy redefined relational intimacy growth within themes participants shed light hurtful embarrassment shame experienced families associated diagnostic label given loved one label perceived either trigger separation hurt immobility ignorance precipitate frenzy naive yet hopeful energy seeking elusive cure participants saw role one enacting new way connecting could thus modelled advocacy integral care relational intimacy validation came witnessing redefining intimacy many families able embrace holistic empathic approach shifting presentation dementia psychological well observed occur families embraced growthful domains acceptance hope relational closeness altruistic concern families implications future care models discussed
central behavior cognition way sensory stimuli represented neural systems distributions stimuli enjoy rich structure however brain captures exploits regularities unclear consider different sources perhaps prevalent form structure namely hierarchies one prevalent cases namely representation images review experimental approaches across range subfields spanning inference memory recall visual adaptation investigate constrain hierarchical representations also discuss progress building hierarchical models representation images potential clarify structure world reflected biological systems suggest need closer embedding recent advances machine learning computer vision design interpretation experiments notably utilizing understanding structure natural scenes creation hierarchically structured synthetic stimuli
state art modal identification civil structures limited estimation mode shapes low spatial resolution modal coordinates identified location sensors fixed particular locations structure increasing number sensors structure alternative increase spatial resolution unfortunately increases cost instrumentation data transmitted processed another common alternative use numerical algorithms expand modal coordinates nonmeasured degrees freedom however mode shape expansion techniques could introduce errors identified modes paper presents formulation evaluation validation methodology ambient vibration based modal identification using mobile sensors mims methodology uses two sensors one mobile one stationary sensor identify spatially dense modes vibration methodology experimentally verified using uniform simply supported steel beam results show mims able identify dense mode shapes using fraction sensors data compared traditional modal identification techniques american society civil engineers
digital dual mode linear quadratic regulator lqr feedforward optimal controller presented allows voltage control boost converter wide load range condition whether continuous conduction mode ccm discontinuous conduction mode dcm based conventional lqr method proposed controller designed makes following two improvements first order eliminate phase error caused right half phase zero emerged non minimum phase boost converter feedforward controller implemented zero phase error tracking control technique inverse non minimum phase system unstable second since models converter ccm dcm different proposed control strategy allows boost converter autonomously operate ccm dcm controller utilising mode detector proposed mode detector greatly enhances control performance operating modes finally proposed controller implemented voltage control boost converter simulation experimental results show proposed controller offers better performance transient response frequency response conventional lqr controller
background aim study investigate cerebral endothelial dysfunction patients reversible cerebral vasoconstriction syndrome rcvs methods prospectively recruited patients rcvs age matched controls episodic migraine age matched healthy controls samsung medical center apr jul participants underwent transcranial doppler evaluation breath holding maneuver evaluation bilateral middle cerebral arteries mcas posterior cerebral arteries pcas basilar artery breath holding index bhi used measure cerebral endothelium dependent vasodilation follow bhis recorded selected patients rcvs months results total subjects recruited study group rcvs episodic migraine healthy control mean age years rcvs group showed lower bhis basal arteries comparison healthy controls bilateral mcas bilateral pcas compared migraineurs rcvs patients lower bhis anterior circulation bilateral mcas bilateral pcas patients follow bhis months showed complete normalization three conclusions cerebral endothelial function impaired widespread distribution rcvs role pathogenesis clinical outcome rcvs determined studies
hydraulic free piston engine integrates internal combustion engine hydraulic pump piston hfpe connected crankshaft piston movement determined forces act upon features optimize combustion make higher power density efficiency increase paper detailed thermodynamic energy saving analysis performed demonstrate fundamental efficiency advantage hfpe thermodynamic results show combustion process optimized ideal engine cycle experimental results show hfpe combustion process nearly constant volume process efficiency approximately piston displacement velocity curves cycle frequency even maximum velocities value high low frequencies similarly pump output flow influenced frequency independent cyclic characteristics hfpe determine work higher frequencies vehicle runs japanese road conditions indicates higher working frequency lead starting frequency hfpe lower frequency decrease pressurized pressure hydraulic accumulator elsevier ltd rights reserved
although research shown interventions within educational contexts based direct face face contact effective reducing prejudice may difficult implement recent research demonstrated also indirect contact useful strategy improve intergroup relations present work focus three forms indirect contact received consistent attention social psychologists recent years vicarious contact extended contact imagined contact interventions reviewed support indirect contact strategies effective flexible means reducing prejudice within schools final part article discuss theoretical practical implications literature review provide suggestions future research
objective study explore gender constructed english ethiopia student book grade four order find discursive actions representations identifications unpacking employed genre discourse style respectively case study conducted using fairclough three dimensional model critical discourse analysis despite ethiopia gender sensitive education training policy findings revealed texts book manifestation struggle discourse tries maintain existing social order gender construction one hand attempts change status quo discursive actions identifications characters promote egalitarian gender construction activity attribute based representations characters reproduce existing stereotypical gender constructions society fall line functionalists perspective gender roles
purpose study analyze association sport personal factors incidence injuries frequency severity according individual swimming tennis athletics team sports basketball handball football sample comprised athletes non injured males non injured females non injured recruited sports clubs valencia study design quantitative descriptive cross sectional correlational injuries evaluated self report results indicated greater number total injuries higher injury rates associated athletes younger age experienced athletes team sport athletes gender unrelated injuries practical applications results mentioned conclusions study indicated
child sexual abuse csa serious public health problem increases risk physical mental health problems across life course young adolescents responsible substantial portion csa offending yet knowledge validated prevention programs target csa perpetration youth exist existing efforts address csa rely reactive criminal justice policies programs teach children protect neither approach well validated given high rates desistance sexual offending following youth first csa related adjudication seems plausible many youth could prevented engaging first offense goal article examine school based universal prevention programs might used prevent csa perpetrated adolescents review literature risk protective factors csa perpetration identify several promising factors target intervention also summarize literature programs effective preventing adolescent dating violence serious problem behaviors finally describe new csa prevention program development early evaluation make recommendations program design characteristics including unambiguous messaging parental involvement multisession dosage skills practice bystander considerations
homelessness serious consequences youth heighten need mental health services however individuals face significant barriers access new models intervention delivery required improve dissemination mental health interventions tailor services unique challenges faced homeless youth purpose study better understand homeless youths use technology mental health experiences needs willingness engage technology supported mental health interventions help guide development future youth facing technology supported interventions five focus groups conducted homeless youth female urban shelter youth years old current periods homelessness ranging days years transcripts focus groups coded identify themes homeless youth reported using mobile phones frequently communication music social media indicated lack trust history poor relationships mental health providers despite recognizing need general support well help specific mental health problems although initial feelings toward technology share information provider mixed reported acceptance tracking sharing information certain circumstances based results provide recommendations development mental health interventions population focusing technology based treatment options
isolate metarhizium anisopliae used commercial hybrids bombyx mori larvae evaluate biological effect symptomatological analyses showed typical signs fungal infection histopathology revealed presence large numbers hemocytes hemocoel sixth dpi bodies insects appeared colonised fungus isolate pathogenic larvae mori therefore death insects caused colonization fungus epidermal mesodermal tissues
renin angiotensin system important component cardiovascular control regulated various conditions including hypertension menopause aim study evaluate effects swimming training estrogen therapy angiotensin ang induced vasoconstriction angiotensin ang induced vasorelaxation aortic rings ovariectomized spontaneously hypertensive rats animals divided sham ovariectomized ovx ovariectomized treated ovariectomized plus swimming osw ovariectomized treated plus swimming groups entailed administration beta estradiol three times per week swimming undertaken sixty minutes day five times per week training initiated seven days following ovariectomy forty eight hours last treatment training session animals systolic blood pressures measured blood samples collected measure plasma ang ang levels via radioimmunoassay aortic rings vascular reactivity ang ang assessed expression ang aortic wall analyzed immunohistochemistry results showed exercise increased plasma ang levels despite attenuating systolic blood pressure ovariectomy increased constrictor responses ang decreased dilatory responses ang reversed swimming independently moreover observed apparent increase ang content aorta groups subjected training exercise training may play cardioprotective role independently may alternative hypertensive postmenopausal women elsevier inc rights reserved
continuous monitoring chemicals environment important control fate protect human health flora fauna perfluoroalkyl acids pfaas detected frequently different environmental compartments last years drawn much attention environmental persistence omnipresence bioaccumulation potential water important source transport present study distributions pfaas river water wastewater treatment plant wwtp effluent tap water eastern part germany western part kenya investigated eleven perfluorocarboxylic acids pfcas five perfluorosulfonic acids pfsas analyzed using liquid chromatography tandem mass spectrometry sum mean concentrations eight pfaas detected drinking tap water leipzig dominated perfluorooctanoic acid pfoa sums mean riverine concentrations pfaas detected plei beta white elster saale elbe germany respectively annual flux pfaas river saale estimated effluent wwtp halle found contain four times higher levels pfaas river water dominated perfluorobutane sulfonate pfbs times higher concentration riverine level advocates wwtps point source contaminating water bodies pfaas short chain pfaas substituting long chain homologues sums mean riverine concentrations pfaas sosiani kenya samples sparsely populated densely populated areas respectively indicating population directly affected emissions pfaas surface waters discussion includes thorough review comparison recently published literature reporting occurrence pfaas aqueous matrices
posterolateral tibial plateau fractures uncommon diagnosis easily missed treatment technically demanding easily lead malunion posterolateral tibial plateau fracture describe innovative intra articular osteotomy treatment posterolateral tibial plateau fracture malunion patients posterolateral tibial plateau fracture malunion treated trauma center patients referred instability knee pain instability confirmed physical examinations preoperatively depression malunion lower limb alignment evaluated rays computed tomography scans posterolateral tibial plateau fracture malunions treated innovative intra articular osteotomy via extended anterolateral approach mean follow months range months posterolateral osteotomy healed average weeks depression malunion corrected patients preoperatively months postoperatively average lysholm knee society score visual analog scale scores respectively loss reduction nonunion wound infection observed innovative intra articular osteotomy via extended anterolateral approach effective treatment posterolateral tibial plateau fracture malunion treatment achieved satisfactory functional results knee stability restoration
consider nanopore network simple connectivity demonstrating two dimensional circuit full wave rectifier ensembles conical pores acting nanofluidic diodes bridge nanopore network fed input potential signal fluctuating polarity fixed output polarity obtained full wave rectification characteristics demonstrated square sinusoidal white noise input waveforms charging load capacitor located two legs bridge demonstrates nanofluidic network effectively coupled electronic element results relevant energy transduction storage procedures nanopores immersed electrolyte solutions individual nanofluidic resistances modulated chemical electrical optical signals balanced bridge circuit also useful miniaturize nanopore based sensing devices elsevier rights reserved
development advanced manufacturing engineering selecting supplier scientifically makes improving competitive power evaluative architecture afforded method confirming supplier evaluation indicator weight based theory entropy lies information given model supplier selection build finally example given illustrates method avail select supplier enhance enterprise competence
immense work presented paper high frequency sinusoidal oscillator using positive second generation current controlled conveyor cccii minimum passive components cccii implemented using single current feedback operational amplifier cfoa single operational trans conductance amplifier ota frequency time period cccii tuned maximum mhz using external bias current performance proposed circuit practically verified using ics cfoa ota results inciuded topology suitable monolithic fabrication
many cryptosporidium species genotypes considered infectious humans realistic estimations seasonal infection risks could made using human infectious species genotype information inform quantitative microbial risk assessments qmra cryptosporidium oocyst concentration species genotype data collected three surface water surveillance programs two river basins south nation river grand river ontario canada evaluate seasonal infection risks main river stems tributaries agricultural drainage streams water treatment plant intakes waste water treatment plant effluent impacted sites sampled qmra employed two sets exposure data compute risk one assuming observed oocysts infectious humans based fraction oocysts hominis parvum dominant human infectious forms parasite viability considered relative infection risk evaluated using single hypothetical recreational exposure many sample site groupings river systems significant seasonality cryptosporidium occurrence concentrations occurrence concentrations generally highest autumn autumn summer mean risk values probability infection per exposure sites combined river system roughly order magnitude lower avg considering parvum hominis oocysts relation mean infection risk per exposure assuming oocysts infectious humans seasonality mean risk targeted human infectious oocysts strongly evident spring summer differences important qmra used quantify effects water safety quality management practices inputs vast array fecal pollution sources readily occur cryptosporidium seasonality water appears match seasonality human infections cryptosporidium study regions study highlights importance cryptosporidium species genotype data help determine surface water pollution sources seasonality well help accurately quantify human infection risks parasite crown copyright published elsevier ltd rights reserved
past decade lean manufacturing reshaped manufacturing processes numerous corporations even organizations already conscious quality cost delivery benefited tremendously principles foundation lean manufacturing elimination non value added elements waste three important value streams realization product engineering value stream manufacturing value stream information management value stream paper focuses engineering value stream methods lean manufacturing applied waste elimination engineering dissemination lean manufacturing principles engineering would multiply significant benefits already derived embracing lean manufacturing part enterprise little attention given systematic method lean engineering aims reducing engineering lead time also identifying measuring eliminating waste engineering processes engineering organizations lack basic methodology waste elimination paper proposes systematic ten step method engineering waste elimination systematic method help engineering organizations systematically identify measure eliminate engineering wastes engineering processes systematic method used demonstrate elimination waste engineering application manufacturing equipment installation manufacturing engineering process today competitive world ability bring better products market faster become focal point competition use systematic method engineering waste elimination holds significant promise organizations wanting outperform competitors quality cost delivery
objective building recent models anorexia nervosa emphasize importance impaired social cognition development maintenance disorder present study aimed examining whether women difficulties inferring people emotional nonemotional mental states healthy women method social cognition assessed adult women age matched healthy women overcome limitations previous research social cognition processing social information examined complex ecologically valid manner movie assessment social cognition masc reflects complex real life social interaction allows disentangling emotional non emotional mental state inference well different types errors mentalizing results women showed poorer emotional mental state inference whereas non emotional mental state inference largely intact groups differ undermentalizing overly simplistic theory mind overmentalizing overly complex interpretative mental state reasoning performance masc independent levels eating disorder psychopathology symptoms depression anxiety discussion findings suggest associated specific difficulties emotional mental state inference despite largely intact nonemotional mental state inference upon replication larger samples findings advocate stronger emphasis socio emotional processing treatment wiley periodicals inc
shaking smothering response infant crying life threatening child abuse parental childhood abuse history known one robust risk factors abusing offspring addition childhood abuse history adverse childhood exposures aces need considered due occurrence however studies investigated impact aces caregivers shaking smothering infant study aims investigate association aces shaking smothering among caregivers infants japan questionnaire administered caregivers participating four month health checkup september august chiba city japan assess aces parental death parental divorce mentally ill parents witness intimate partner violence physical abuse neglect psychological abuse economic hardship shaking smothering toward infants logistic regression analysis used examine cumulative individual impacts aces shaking smothering analyses conducted total reported experienced least one ace childhood found witness ipv significant association shaking infant total number aces associated either shaking smothering findings suggest shaking smothering response crying occur regardless aces population based strategies target caregivers prevent shaking smothering infants needed elsevier ltd rights reserved
kidney diseases well lower urinary tract diseases occur relatively often pigs especially sows occasionally acids used sow feeding prevent urinary tract diseases lowering urine systemically acting acidification influences acid base mineral homeostasis possibly also kidney health animals laboratory diagnostic especially metabolite analyses urine pigs value scope herd management urine samples quite easily obtained using spontaneously emicted midstream urine representative group sows immediate measuring sensory assessment sample well measuring nsba laboratory proven useful parameters depending investigated issue following parameters analyzed protein creatinine density ggt sediment erythrocytes leukocytes epithelial cells well bacteriological molecular diagnostic methods pathogen identification values mentioned parameters vary depending feeding watering management least use acids therefore preliminary standard values given evaluate particular parameters based two case reports implementation urine analyses sows demonstrated encourage veterinarians use urine sampling pig herd management
set simple models proposed study measure cost direct effects water pollution human resources inductive reasoning used developing applying models hypothetical case demonstrate feasibility practicability proposed models testing validity applicability proposed models professional accountant may recognize accounting transactions tangibly financial statements polluted companies improve quality companies financial reporting
paper proposes system design weighted pendulum type electromagnetic generator harvesting energy rotating wheel different traditional energy harvesting device natural frequency suitable weighted pendulum oscillates due periodic change tangential component gravitational force match rotational frequency wheel speed addition pendulum oscillates large angle angular velocity generate large amount power physical model pendulum first constructed equation motion derived via lagrange method models power generation derived using faraday law induction lorentz force law nonlinear dynamic behaviors discussed considering characteristic length variable electromagnetic damping wheel rotation speed finally experimental rig constructed verify correctness numerical results suitable weighted pendulum combined coils magnets demonstrated power generation several hundred micro watts experiment
clustering data continues highly active area data analysis resemblance profiles incorporated ecological methodologies hypothesis testing based approach clustering multivariate data however new clustering techniques rigorously tested determine performance variability based algorithm assumptions underlying data structures use simulation studies estimate statistical error rates hypothesis test multivariate structure based dissimilarity profiles disprof concurrently tested widely used algorithm employs unweighted pair group method arithmetic mean upgma estimate proficiency clustering disprof decision criterion simulated unstructured multivariate data different probability distributions increasing numbers objects descriptors grouped data increasing overlap overdispersion ecological data correlation among descriptors within groups using simulated data measured resolution correspondence clustering solutions achieved disprof upgma reference grouping partitions used simulate structured test datasets results highlight dynamic interactions dataset dimensionality group overlap properties descriptors within group overdispersion correlation structure relevant resemblance profiles clustering criterion multivariate data methods particularly useful multivariate ecological datasets benefit distance based statistical analyses propose guidelines using disprof clustering decision tool help future users avoid potential pitfalls application methods interpretation results
oropharyngeal candidiasis opc caused predominantly candida albicans prevalent infection patients advanced aids defects immunity head neck cancer characteristic feature opc fungal invasion oral epithelial cells one mechanism albicans hyphae invade oral epithelial cells expressing als ssa invasins interact epidermal growth factor receptor egfr epithelial cells stimulate endocytosis organism however signaling pathways function downstream egfr mediate albicans endocytosis poorly defined report albicans infection activates aryl hydrocarbon receptor ahr leading activation src family kinases sfks turn phosphorylate egfr induce endocytosis fungus furthermore treatment oral epithelial cells interferon gamma inhibits fungal endocytosis inducing synthesis kynurenines cause prolonged activation ahr sfks thereby interfering albicans induced egfr signaling treatment immunosuppressed immunocompetent mice ahr inhibitor decreases phosphorylation sfks egfr oral mucosa reduces fungal invasion lessens severity opc thus data indicate ahr plays central role governing pathogenic interactions albicans oral epithelial cells opc suggest receptor potential therapeutic target importance opc caused predominantly fungus albicans invade oral epithelium several mechanisms one mechanisms induced endocytosis stimulated fungal invasins bind epithelial cell receptors egfr receptor binding causes rearrangement epithelial cell microfilaments leading formation pseudopods engulf fungus pull epithelial cell discovered ahr acts via sfks phosphorylate egfr induce endocytosis albicans finding small molecule inhibitor ahr ameliorates opc mice suggests strategy targeting host cell signaling pathways govern epithelial cell endocytosis albicans holds promise new approach preventing treating opc
study authors propose novel method encrypt colour image use logistic mapping double random phase encoding firstly use logistic mapping diffuse colour image red green blue components result scrambled replacement matrices generated logistic mapping secondly utilising double random phase encoding encrypt three scrambled images one encrypted image experiment results reveal fact proposed method achieve good encryption result also key space large enough resist common attack
background incorporating evidence based integrated treatment dual disorders typical care settings challenging especially among serving veterans homeless paper presents evaluation effort incorporate evidence based dual disorder treatment called maintaining independence sobriety systems integration outreach networking veterans edition mission vet case management teams serving veterans homeless using implementation strategy called getting outcomes gto methods hybrid type iii cluster randomized controlled trial assessed impact gto mission vet implementation usual conditions received standard mission vet training manuals gto group received implementation manual training technical assistance data feedback study occurred teams three large medical centers years within team existing sub teams case managers veterans serve clusters randomly assigned trial assessed mission vet services delivered collected via administrative data implementation barriers facilitators via semi structured interview results case managers group initiated mission vet gto group seven percent veterans case managers gto group received least one mission vet session case managers appreciated mission vet materials felt gto planning meetings supported using mission vet case manager interviews also showed mission vet could confusing little involvement leadership initial agreement participate data feedback system number difficulties case managers resources implement aspects mission vet conclusions project shows gto like support help launch new practices multiple implementation facilitators needed successful execution complex evidence based program like mission vet
analysis paired cerebrospinal fluid csf serum samples isolectric focusing ief yield different patterns aid differential diagnosis central nervous system cns disorders rarely single csf restricted igg band included within patterns detected association inflammatory disorders multiple sclerosis however diagnostic meaning abnormality still uncertain main aim multicenter study establish frequency disease associations single csf igg bands differences csf profiles diseases follow patterns also evaluated medical records patients underwent csf analysis included ief year period retrospectively scrutinized participating centers used similar ief techniques one hundred fifty one csf reports showed single csf restricted igg bands patients definite diagnosis cns inflammatory demyelinating diseases frequent tumours inflammatory peripheral nervous system diseases miscellaneous diseases follow patients repeated csf analysis developed oligoclonal band pattern findings indicate single csf igg bands tend associate diseases characterized involvement intrathecal humoral immune responses strongly support notion abnormality regularly reported thus alerting clinicians possible inflammatory disorders cns
airborne lidar bathymetry alb effective rapidly advancing technology mapping characterizing shallow coastal water zones well inland fresh water basins rivers lakes ability light beams detect traverse shallow water columns provided valuable information unmapped often poorly understood coastal inland water bodies world estimating alb survey results varying water clarity depth conditions essential realizing project expectations preparing budgets accordingly remote locations world situ water clarity measurements feasible possible using multiband satellite imagery effective tool estimating addressing considerations purpose studied classified reflected electromagnetic energy selected water bodies acquired rapideye sensor correlated findings alb survey results study focused accurately measuring depth optical bathymetry rather using multiband satellite imagery quickly predict alb survey results identify potentially turbid water bodies limited depth penetration study constructed house algorithm confirm alb survey findings using bathymetric waveform information study findings expected contribute ongoing understanding forecasting alb survey expectations unknown varying water conditions especially remote inaccessible parts world elsevier rights reserved
paper devoted study statistical mechanics trapped gravitons obtained trapping spherical gravitational wave box consequence discrete spectrum dependent legendre index similar harmonic oscillator one obtained statistical study performed mean energyresults sum two discrete planck distributions different dependent frequencies important application derive semiclassical bekenstein hawking entropy formula static schwarzschild black hole requiring black hole internal energy provided adm rest energy without invoking particular quantum gravity theories seriously suggests interior black hole composed trapped gravitons thermodynamical temperature proportional factor similar equal horizon temperature elsevier rights reserved
study carried hamlin wynn bloom provided concrete evidence infants young months capable social evaluation displaying early preference agents performing prosocial behavior since development early social abilities judge behavior topic growing body research present paper reviews studies conducted experimentally examined infants social evaluation abilities testing preference agents acting prosocially performed detailed analysis corpus research studies including experimental results scrutinizing methods findings identifying convergent divergent features analysis showed preference agents perform prosocial behaviors opposed antisocial neutral present majority infants conflicting results also reported rich interpretation infants endowed mature socio moral evaluation abilities really sufficiently discussed order deepen debate assessed studies explored infants understanding social value behaviors many studies provide evidence young infants manage identify prefer prosocial agent taking account context agents mental states beyond behavior study two specific areas assessed studies previously explored social evaluation abilities beyond basic preference prosocial behavior current theories attempt explain preferences could exist early infancy future directions research social evaluation abilities infants also discussed well review literature elsevier inc rights reserved
background many studies reported significant changes intestinal microbiota irritable bowel syndrome ibs patients based quantitative real time pcr analysis aims aimed review alterations intestinal microbiota methods online search june conducted systematic review meta analysis included differential expression intestinal microbiota patients ibs versus healthy controls hcs subgroup analysis assessed quality included studies using original assessment tool results total articles involving ibs patients healthy controls included quality assessment scores articles ranged significant differences expression ibs patients observed lactobacillus smd bifidobacterium smd faecalibacterium prausnitzii smd bacteroides prevotella group escherichia coli genera species subgroup analysis showed diarrhea predominant ibs patients significantly different expression lactobacillus smd bifidobacterium smd conclusion regulation bacterial colonization including lactobacillus bifidobacterium prausnitzii observed ibs patients particularly diarrhea predominant ibs ibs microbiota changes participate pathogenesis ibs may underlie efficacy probiotic supplements editrice gastroenterologica italiana published elsevier ltd rights reserved
cryptanalysis refers finding plaintext given cipher text problem reduces finding correct key set possible keys basically search problem many researchers put lot effort accomplish task efforts used conventional techniques however soft computing techniques like genetic algorithms generally good optimized search though applicability techniques cryptanalysis still contentious point work carries extensive literature review cryptanalysis techniques finds gaps order put proposed technique perspective work also finds applicability cellular automata cryptanalysis new technique proposed verified texts around words text encrypted times decrypted using proposed technique work also compared employing genetic algorithm experiments carried prove veracity technique paves way cellular automata cryptanalysis paper also discusses future scope work
background declining sharply many years prevalence smoking remained fairly stable past decade one possible explanation increase prevalence barriers cessation like depression among remaining smokers objectives estimate changes prevalence depression among current former never smokers united states population overall age gender income methods data drawn national household survey drug use nsduh annual cross sectional study persons ages prevalence past month depression examined annually among current past month former past month lifetime nonsmokers data analyzed stratified age gender household income adjusted demographics results depression appears significantly increased united states among current former never smokers depression prevalence increased among current smokers overall increase among former never smokers even prominent striking temporal changes emerged age gender income specifically depression increased significantly among current smokers aged value prevalence consistently twice high never smokers depression increased among male smokers value depression increased significantly among smokers highest income group value throughout period prevalence depression among current smokers consistently twice high among former never smokers discussion public health efforts aimed decreasing prevalence smoking take depression account common modifiable barrier whose treatment may help increase successful smoking cessation future work needed disentangle role smoking factors lead increases depression population elsevier rights reserved
work presents high voltage operational amplifier opa opas widely used signal conditioning circuits industrial applications integrated circuits ics particularly applications like bms battery management system signal conditioning circuits always used transfer voltage signal domain low voltage domain notably voltage domain could high tens volts might cause damages regular silicon based transistors nevertheless since resolution signal conditioning circuits depends output range operation range determined input range input output ranges signal conditioning circuits key issue applications propose rail rail opa resolve issues proposed design implemented using poly metal bcd process core area gain unit gain bandwidth proposed railto rail opa measured mhz respectively finally proposed rail rail opa proven silicon receive signals transmit signal range elsevier ltd rights reserved
article presents ongoing research project development content relation cognitive theory multimedia learning previously literature review conducted content development models cognitive theory multimedia learning problems encountered learning computer programming work new framework proposed development content experiment conducted jubilee centre excellence education among secondary school students order assess value proposed framework uses cognitive theory media learning study sample divided two groups one group studied computer programming using content based behavior change techniques using proposed framework bpf group studied computer programming based content based proposed framework nbpf students performance assessed pre test grading scale post test analysis made using statistical package social sciences spss results showed students studied computer programming bpf achieved better scores students studied computer programming nbpf therefore applying cognitive theory multimedia learning properly conditions applied study educational process significantly reduce cognitive overload associated learning multimedia elements improve student achievement
simple design optically pumped flip flop using two gaas algaas based optical microring resonator omrr introduced nonlinear property gaas algaas based ring resonator explored use optical switch high intensity optical pump pulse used switching operation omrr theoretical model proposed flip flop circuit developed applying delay line signal process approach domain model circuit explored analyze performance various performance parameters contrast ratio extinction ratio ratio ton amplitude modulation determined simulation results obtained matlab optimum values ton calculated proposed model confirms feasibility flip flop society photo optical instrumentation engineers spie
article designed bandgap voltage reference source low temperature drift high power supply rejection ratio tcxo chips design sensitive reaction thermal protection circuit used protect tcxo chips structure self biased current source differential operational amplifier used bandgap reference temperature protection circuit controlled oscillator npn transistor detection circuit current simulation results show range voltage output temperature changes power supply rejection ratio circuit high oscillator turned temperature greater degrees restart temperature less degrees turn needs less restart needs less circuit provide stable reference good temperature protection effect great practical value tcxo chip
purpose study examine whether hox transcript antisense rna hotair polymorphisms associated genetic susceptibility rheumatoid arthritis chinese population total participants enrolled study including patients healthy controls hotair polymorphisms detected ligase detection reaction polymerase chain reaction ldr pcr technology significant difference genotype distribution patients healthy controls found difference allele frequencies patients controls also non significant versus odds ratio confidence interval versus versus also evaluated relationships mentioned polymorphisms risk dominant model recessive model non significant evidence found significant evidence detected relationships hotair polymorphisms risk different serotypes results indicated hotair polymorphisms might involved genetic background chinese
paper investigates synergetic effect rooftop solar photovoltaic generation owned residential prosumers power producers consumers reducing distribution substation transformer aging caused charging plug electric vehicles pevs unlike previous work considering surveys based internal combustion engine based vehicle data national household travel survey nhts used estimating charging demand pevs work considers actual pevs charging data based canadian plug electric vehicle survey cpevs work quantifies resultant aging seen substation transformers internal combustion engine based national household travel survey data compared plug electric vehicle driving data canadian plug electric vehicle survey moreover comparison substation transformer aging performed based varying plug electric vehicle charging levels results scenarios shown substation transformer loss life found least higher vehicle data based plug electric vehicle studies versus conventional internal combustion engine vehicles penetration twice high penetration studies shown grouped plug electric vehicle charging using results twice transformer aging seen versus plug electric vehicles charging beginning upon returning home finally results shown effect rooftop solar owned residential prosumers found reduce substation transformer loss life case plug electric vehicle charging penetration added system reduction due decrease transformer winding hot spot temperature caused generation despite non coincidence peak charging demand plug electric vehicles peak power generation rooftop solar photovoltaic elsevier rights reserved
first kind pilot scale redox based thermochemical storage system set operated near realistic conditions inside solar power tower plant storage unit made inert honeycomb supports cordierite coated redox active material cobalt oxide experimental campaign carried consisting thermochemical charge discharge cycles heat absorbed released chemical reaction became clearly evident temperature evolution inside reactive material allows store release energy constant temperature crossing respectively reduction oxidation temperature coo coo pair storage performance factor defined evaluate experiment approaches ideal behavior complete campaign measurable cycle cycle degradation observed system average capacity close ideal case advantage thermochemical storage could quantified comparing storage capacity sensible storage unit made uncoated cordierite honeycombs thermochemical system offered almost double storage capacity volume sensible case elsevier ltd rights reserved
paper reports recent advances development symbolic asymptotic modeling software package memsalab used automatic generation asymptotic models arrays micro nanosystems first asymptotic model stationary heat equation micro mirror array developed astrophysics presented together key elements derivation illustrates mathematical operations need implemented memsalab principle operation software construct models incrementally model features included step step idea conceptualized name extension combination presented first time recalled general functioning principles friendly user language recently introduced also shortly discussed
image inpainting dynamic field different image processing computer graphics applications existing image inpainting methods lead significant results different applications fail difficult situations high local structural variations paper structure based image inpainting algorithm proposed image structure layer represented analyzed using structure tensor field structure layer image first inpainted adapting efros leung algorithm specificities structure tensor obtained tensor field used help image inpainting process results show using proposed method relevant local information better inpainted comparing initial intensity based approach consider structural information inpainting process
memory reports usually provide evidence determinative guilt innocence criminal proceedingsincluding serious proceedings capital murder trials thus memory research bedrock science comes reliability legal evidence expert testimony research linchpin verdicts principle illustrated capital murder trial several powerful forms memory distortion present phantom recollections robust interrogation methods stimulate false self incrimination key question jury whether regard defendant confession true false turned theoretical principle used explain memory distortion laboratory verbatim gist distinction research showing possible create false memories embody gist experience scientific testimony focused instances false gist memories created controlled conditions lost mall receiving surgery fictitious injury well real life examples false memory gist experience recovered memories sexual abuse alien abduction memories defendant found innocent capital murder
present study used functional magnetic resonance imaging investigate mother experience neglect childhood associated neural response infant distress cues scanning high risk primiparous mothers exposed month old infant cry sound control sound mothers continuous neglect subscale scores childhood trauma questionnaire examined predictor neural response infant cry control sound mothers reported high levels neglect childhood showed regions hyperactivation infant cry relative control sound anterior posterior cingulate cortices insula well specific prefrontal precentral gyrus parietal posterior supramarginal gyrus areas results may suggest important early life experiences future parenting responses behaviors
constant supply epithelial cells dental epithelial stem cell desc niches cervical loop enables mouse incisors grow continuously throughout life elucidation cellular molecular mechanisms underlying unlimited growth potential broad interest tooth regenerative therapies fibroblast growth factor fgf signaling essential development mouse incisors maintenance prenatal development however fgf signaling descs controls self renewal differentiation cells well understood herein report fgf signaling essential self renewal prevention cell differentiation descs well desc spheres inhibiting fgf signaling pathway decreased proliferation increased apoptosis cells desc spheres suppressing fgfr downstream signal transduction pathways diminished lgr expressing cells promoted cell differentiation desc spheres furthermore disruption fgf pathway abrogated wnt signaling promote lgr expression descs vitro vivo study sheds new light understanding mechanism homeostasis expansion differentiation descs regulated
purpose investigate chromatic characteristics intensity response function light induced reflex lacrimation correlation melanopsin driven postillumination pupil response pipr methods eleven visually normal participants completed experiment lacrimation measured one eye placing calibrated filter paper strip conjunctival sac minute interval schirmer test participants received either light stimulation baseline trial one flash blue red light stimuli presented binocularly ganzfeld stimulator pupil response recorded simultaneously fellow eye using eye tracker light stimulation trials presented alternating fashion seven incremental intensity steps postillumination pupil response defined mean pupil constriction seconds post illumination results amount lacrimation response blue light significantly greater baseline increased monotonically increasing light intensity red light induce significant reflex lacrimation brightest stimulation positive linear correlation pipr lacrimation response blue light red light conclusions chromatic characteristics intensity response light induced lacrimation highly consistent features melanopsin phototransduction finding first vivo evidence humans supporting hypothesis light induced reflex lacrimation mediated primarily melanopsin photoactivity provides new insight putative mechanisms photophobia
thermotropic liquid crystals often referred mesogens containing transition metals metallomesogens specifically lanthanides lanthanidomesogens would benefit rational correlations microscopic variations introduced chemists molecular structures planned macroscopic properties temperature domain existence viscosity supramolecular organization novel concept cohesive free energy density cfed allows building pseudo phase boundaries connect chemical perturbations usually measured help arbitrary structural parameters quantitative pressure increments relevant found pressure temperature phase diagrams help novel toolkit cyanobiphenyl based dendrimeric tridentate ligands used proof concept exploring consequences successive methylation polyaromatic termini complexation luminescent europium carriers iii statistical doping structural defects thermodynamic parameters control phase transitions elsevier rights reserved
objective purpose study examine association asthma diagnosis obesity among adolescents exposed environmental tobacco smoke ets methods sample included adolescents years old national survey children health nsch study design nsch cross sectional telephone survey included least one child ages years residing household time interview descriptive statistics used describe sample characteristics assess prevalence asthma among adolescents obesity exposed ets logistic regression models built assess effect obesity asthma diagnosis within context ets exposure results prevalence asthma among adolescents obesity adolescents obesity exposed ets within home significantly likely asthma diagnosis compared non obese residing similar households adjusted odds ratios showed adolescents obesity times likely asthma exposed ets inside homes conclusion findings indicate adolescents obesity likely diagnosed asthma exposed ets household important association obesity asthma examined within context environmental risk factors future studies may shed light underlying mechanisms two serious public health issues
recently various feature extraction techniques variations proposed computer vision however techniques sensitive images acquired uncontrolled environment illumination expression occlusion face images result random error entries days matrix representing face techniques principal component analysis pca handle entries explicitly paper proposes two dimensional whitening reconstruction twr pre processing step coupled pca algorithm combined method would process illumination expression variations better standalone pca technique compared state art two dimensional whitening reconstruction twr pre processing method final results clearly indicate reason better performance twr twr histograms plotted algorithms show twr makes smoother frequency distribution twr proposed method indicated increased recognition rate accuracy increasing number training images images images training images
polytechnic education type higher education singapore focuses technical industrial oriented education observed recent student enrolment significant increase number overseas students enrolling polytechnic rising concern among educators potential differences approach learning differences lead difficulties student engagement academic material design student performance assessment name difference schooling cultural traditions lead difference understanding learning actually differences lead students different strategies behaviours regulate learning example general asian students traditional educational concept emphasis rote memorization way learning tend contrast strongly acceptance independence thought verbal assertiveness learning development meaning generally promoted desirable behaviours among european students recent years rapid development information communication technology ict played increasingly important role education adoption technology teaching learning become next step towards enhancing learning experience polytechnic students introduction technology enhance learning experience invariably leads explosion new ideas creative ways engaging students nanyang polytechnic school information technology teaching community already started introduce online tools material repository dissemination online learning assessments project group collaboration discussion work means students different cultural educational background adopt technology based online learning environment polytechnic education research therefore aims study interaction international polytechnic students diverse cultural educational backgrounds solve range problems form computer programming tasks within online learning environment using eye tracking technology preliminary findings led suggest students different educational foundations different countries shown significant differences learning progress performing tasks within online learning environment findings thus help educators promote learning among diverse group students personalised differential learning models
paper shows method developed van steenwijk generalized calculate resistance two vertices symmetrical polytope whose edges identical resistors method applied number structures considered earlier archimedean polyhedra duals three dimensions regular polytopes four dimensions hypercube number dimensions
urinary tract dysfunction older patients multifactorial aetiology uniform clinical condition changes due physiological ageing well comorbidity polypharmacy produce several dynamic conditions urinary incontinence urinary retention lower urinary tract symptoms increase age sexes major problem older patients due medical psychosocial consequences reasons assessing urinary dysfunction older patients consider external circumstances polypharmacy poor mobility affective cognitive disorders also accessibility housing elsevier espana rights reserved
paper discusses concepts current trends structure wholesale electricity markets additionally reviews structure electricity markets world also reviews experience around system operation market operation well main processes handled european american markets review shows various designs markets converging depending needs structures trends turn around presence tso iso market operator well operation derivatives markets
objectives examine hierarchical visuospatial processing children neurofibromatosis type single gene disorder associated visuospatial impairments attention deficits executive dysfunction methods used modified navon paradigm consisting large global shape composed smaller local shapes either congruent incongruent different global shape participants instructed name either global local shape within block reaction times interference ratios error rates children typically developing controls compared results typically developing participants demonstrated expected global processing bias evidenced vulnerability global interference naming local stimuli without cost congruence naming global stimuli participants however experienced significant interference unattended level naming local global levels stimuli conclusions findings suggest children demonstrate typical human bias processing visual information global perspective
paper introduces two voltage controlled memristor based reactance less oscillators analytical circuit simulations two different topologies discussed function reference voltage generalized formulas oscillation frequency conditions oscillation topology derived effect reference voltage circuit performance studied validated different examples using pspice simulations memristor based voltage controlled oscillator vco introduced application proposed circuits nano size efficient compared conventional vcos copyright john wiley sons ltd
prevalence atopic dermatitis increased substantially previous studies focused mostly pediatric patients epidemiological investigation adult limited aim study determine prevalence clinical features adult outpatients dermatitis eczema china mainland multicenter cross sectional study conducted among outpatients eczema dermatitis tertiary hospitals provinces china july september patients adult compared adults types dermatitis mean age years onset age years adult younger mean disease duration longer years adult involved body locations higher adults types dermatitis lower pediatric adolescent history asthma allergic conjunctivitis common adult pediatric adolescent suspected bacterial infection frequently adult adults types dermatitis pediatric adolescent severe itching observed adult higher adults types dermatitis highest lowest prevalence adult degrees degrees degrees degrees latitude region substantial part adult outpatients eczema dermatitis adult middle age body location involvement suspected bacterial infection severe itching main clinical feathers adult geographical environment economic situation work synergy adult
researchers investigated association among food addiction difficulties emotion regulation mentalization deficits sample italian adults general population participants administered italian versions yale food addiction scale yfas difficulties emotion regulation scale mentalization questionnaire binge eating scale michigan alcohol screening test respondents reported high food addiction symptoms symptoms food addiction yfas bivariate analyses high food addiction symptoms associated difficulties emotion regulation mentalization deficits multivariate analysis high food addiction symptoms remained independently associated mentalization deficits difficulties emotion regulation data suggest mentalization may play important role food addiction making difficult individual understand inner mental states well mental states others especially powerful emotions arise
intelligent material new marginal subject developing world today belongs frontier research field intersection multi subjects characteristics inherent smart materials therefore important application value paper discusses concept intelligent materials two kinds new intelligent materials basic properties smart material actuator application intelligent control compared traditional materials compared smart materials exhibit superior quality
thermal energy storage height popularity harvest store save energy short term long term use new energy generation systems forecasted global thermal energy storage market cross million revenue highest growth expected europe middle east africa followed asia pacific region thermal energy storage become inevitable component fluctuant renewable energy systems due significant role increasing efficiency quality service qos currently one major research stream systems improving efficiency heat exchangers heat carriers hence studying thermal behavior thermophysical properties heat storages great importance study review common well known problem supercooling phase change materials pcm supercooling thermophysical property pcms problematic thermal storage applications review looks supercooling another point view investigates applications specialized thermal storage applications put supercooling operation achieve development techniques increase state stability designing reliable stable supercooled heat storage systems investigated study look thermal energy storage supercooled liquids degree measurement supercooling furthermore factors influence degree supercooling effect output capacity discussed looks supercooled material four major categories looks mechanisms triggering crystallization supercooled liquids applications including solar thermal storage discussed details results discussed review researchers identify gain insight supercooling control techniques necessary developing efficient heat exchangers also essential promoting adoption sustainable renewable energies
objective review critically examines structural neuroimaging evidence psychotic illness focus longitudinal imaging across first episode psychosis ultra high risk psychosis illness stages methods thorough search literature involving specifically longitudinal neuroimaging early illness stages psychosis conducted evidence supporting abnormalities brain morphology altered neurodevelopmental trajectories discussed context clinical staging model results general grey matter lesser extent white matter declines across multiple frontal temporal especially superior regions insular parietal regions first episode psychosis steeper trajectory age matched healthy counterparts although ultra high risk psychosis literature considerably mixed evidence indicates certain volumetric structural aberrations predate psychotic illness onset prefrontal cortex thinning abnormalities present ultra high risk psychosis populations potentially non psychosis specific hippocampal volume reductions conclusion highlight advantages longitudinal designs discuss implications studies clinical staging provide directions future research
polyacrylonitrile fibers panf covalently modified lysine pan lys facilely synthesized carefully characterized critical factors affecting adsorption aqueous solution exploited initial contact time concentration temperature adsorption process strongly dependent solution excellent adsorption capacity high affinity toward process extremely rapid equilibrium reached within min thermodynamics kinetics strictly evaluated addition hypothetical adsorption mechanisms proposed moreover adsorption behavior low concentrations simulated seawater also investigated therefore pan lys potentially utilized efficient removal seawater elsevier rights reserved
illustrate algorithm starting image representation strictly bounded real system computes minimal balanced state variable minimal balanced state realization readily obtained algorithm stems iterative procedure compute storage function based technique solve generalization nevanlinna interpolation problem
need green energy increases particularly solar energy perovskite based devices become promising alternative complex costly semiconductor based photovoltaic devices major advantage perovskite based devices relatively facile fabrication thin film fairly low temperatures tunable optoelectronic properties chemical composition perovskite structures solvent heat treatments used processing additives deposition methods produce films different morphologies ability used organic inorganic subcells makes useful component efficient cost effective approach harvest solar energy review presents latest approaches considerations fabrication architecture performance perovskite based solar cells various perovskite device architectures discussed well effects environmental conditions performance degradation
paper stability local bifurcation rotating blade high temperature supersonic gas flow investigated using analytical numerical methods based obtained four dimensional averaged equation case internal resonance primary resonance two types critical points bifurcation response equations considered points characterized double zero two negative eigenvalues two pairs purely imaginary eigenvalues respectively type steady state solutions stability region obtained aid center manifold theory normal form theory find hopf bifurcation solution indicates blade flutter summary numerical solutions whose initial conditions chosen stability region agree analytic results elsevier inc rights reserved
study novel auditory version single category implicit association test iat developed investigate valence adults associations infant cries laughs moderation implicit associations gender empathy robustness implicit associations controlling auditory sensitivity eighty adults females administered two iat empathy quotient weinstein noise sensitivity scale adults showed positive implicit associations infant laugh negative ones infant cry implicit associations infant laugh negatively related empathy scores gender differences observed finally implicit associations infant cry affected noise sensitivity iat useful evaluate valence implicit reactions infant auditory cues could provide fresh insights understanding processes regulate quality adult infant relationships
vulvovaginal candidiasis vvc common fungal infection affects healthy women ages least women develop one infections lifetime individuals developing recurrent infections view context study sought evaluate antifungal potential isolated citronellal associated therapeutic agents clinical importance enantiomer solubilized tween dimethylsulfoxide dmso posteriorly diluted sterile distilled water concentration minimum inhibitory concentration mic product determined microdilution rpmi obtaining dilutions minimum fungicidal concentration mfc determined sabouraud dextrose agar sda depletion technique aliquots mic mic mic mic mfc values albicans strains respectively susceptibility test albicans presented high resistance fluconazole itraconazole strains however ketoconazole miconazole resistance strains respectively combination testing ketoconazole miconazole resistance completely reverted fluconazole itraconazole resistance reverted strains respectively presented fungicide activity mfc mic combination ketoconazole fluconazole itraconazole miconazole increased inhibition zones antifungal drugs reducing resistance albicans
system rice intensification sri based modifications management practices rice cultivation utilized many countries although without controversy one reason cited non adoption disadoption sri difficulties water management rainfed conditions unreliable aberrant rainfall distribution causes either flooding long dry spells constraints could dealt tapping groundwater resources capture use rainwater runoff diversification farming system year field experiment conducted odisha india evaluate sri rainfed conditions also explore options enhancing economic productivity land water conditions four rice cropping systems evaluated conventional rice cultivation rainfed conditions sri methods adapted rainfed cultivation iii rainfed sri methods drainage facilities supplementary pump irrigation integrated sri isri rainwater runoff harvested stored aquaculture horticulture crops also providing supplementary irrigation rice crop rice crop grown adapted sri practices rainfed condition showed significant improvements plants morphology physiology phenotypic changes included greater plant height tillering number leaves expanded root systems changes accompanied changes plants physiological functions like greater xylem exudation rate light interception canopy increased chlorophyll content leaves higher light utilization photosynthetic rates flowering factors responsible improved yield contributing characteristics higher grain yield compared crops grown conventional production methods comparing yield rainfed conventional sri methods drought normal rainfall years indicated latter methods drought tolerant productive greatly expanded active root systems sri important contributing factors introducing drainage supplementary irrigation improved grain yield water productivity rainfed sri integrating aquaculture horticulture sri management rainwater harvesting increased rice yield net water productivity integrated system found raise net income per unit water fold compared conventional rainfed rice cultivation option looks promising improving food security smallholders erratic diminished rainfall conditions elsevier rights reserved
background angioedema vascular reaction involving lower dermis subcutis submucosal tissue causing temporary localized swelling part body many health care professionals diagnosis presents ongoing challenge several disorders may manifest subcutaneous submucosal swelling falsely assumed angioedema clinicians emergency department immunology allergy clinics must skilled recognizing features angioedema differential diagnosis methods review based literature search specific indexing terms pubmed review bibliographies authors clinical experience results essential diseases mimic angioedema called pseudoangioedemas discussed illustrated clinical photos pointing key features help clarify diagnoses differentiate classic angioedema conclusions variety dermatologic conditions cause swelling resembles angioedema potentially fatal outcome misdiagnosed knowledge pseudoangioedema fundamental emergency setting handling patients edema kept mind assessing atypical angioedema case karger basel
background data psychological harm multiple endocrine neoplasia type men scarce objectives aim study assess anxiety depression quality life coping long standing men patients patients methods patients adults age years clinical genetic diagnosis men long term follow years range years cross sectional study qualitative quantitative psychological assessment using semi directed interviews hads eortc qlq mini mac scales adopting clinical criteria ata guidelines men biochemical cure persistence recurrence stable chronic disease medullary thyroid carcinoma mtc scored pheochromocytoma affected patients previous adrenalectomy results overall anxiety mean score range anxiety defined score depression mean score range depression defined score symptoms frequent patients transmitted ret mutations child higher scores weakness discouragement anxious preoccupation lower scores cognitive emotional physical functioning feelings guilt present patients mutation positive children lower mean score values depression anxiety higher scores role cognitive emotional functioning noticed patients well informed disease fighting spirit frequently found patients multiple surgical procedures controlled chronic adrenal insufficiency patients men elated stress inducing factors lower scores fighting spirit cognitive functioning higher scores insomnia dyspnea eleven patients required sustained psychotherapeutic treatment mean global health status relatively good men cases cured group higher physical functioning conclusions psychological distress likely chronic men patients study identified diverse men related factors degree information disease mutation positive children number surgeries comorbidities stress inducing factors cure interfering positively negatively results psychometrics scales active investigation factors applied psychological assessment protocol useful identify men patients requiring psychological assistance
pricing hedging exotic options using local stochastic volatility models drew serious attention within last decade nowadays became almost standard approach problem paper show framework could extended adding model stochastic interest rates correlated jumps three components also propose new fully implicit modification popular hundsdorfer verwer modified craig sneyd finite difference schemes provides second order approximation space time unconditionally stable preserves positivity solution still linear complexity number grid nodes
background teacher knowledge continues topic debate australasia parts world many attempts mathematics educators researchers define knowledge needed teachers teach mathematics effectively plethora terms mathematical content knowledge pedagogical content knowledge horizon content knowledge specialised content knowledge used describe aspects knowledge purpose paper proposes model teacher knowledge mathematics embraces develops aspects earlier models focuses notions contingent knowledge connectedness big ideas mathematics enact described powerful teaching involves teacher ability set provoke contingent moments extend children mathematical horizons model proposed considers various cognitive affective components domains teachers may require enact powerful teaching intention validate proposed model empirically future stage research sources evidence contingency described rowland knowledge quartet ability respond children questions misconceptions actions able deviate teaching plan needed notion horizon content knowledge ball key aspect proposed model provoked discussion article students mathematical horizons might comprise together deep mathematical content knowledge sensibility students mathematical horizons ideas form foundations proposed model main argument follows deeper level knowledge might enable teacher respond better plan anticipate contingent moments taking considering teacher knowledge dynamic paper suggests instead responding contingent events powerful teaching provoking contingent events necessarily requires broad connected content knowledge based big mathematical ideas sound knowledge pedagogies understanding common misconceptions order able engineer contingent moments conclusions order place genuine problem solving heart learning paper argues idea planning contingent events provoking setting proposed model attempts represent process anticipated new model become framework empirical research project undergoes validation process involving sample primary teachers
preferences scope relational databases allow modeling user wishes queries soft constraints different frameworks database preferences including commercially available systems slightly vary semantics expressiveness common preferences induce strict partial orders given data set present paper study expressiveness preference operators available implementations particularly search decompositions strict partial orders fundamental preference constructs study preference operators operands necessary express strict partial order finally present two decomposition algorithms show correctness
current study examines barack obama presidency lens racialized news framing symbolic racism racial prejudice often manifests subtle symbolic racism called postracial america supporting beliefs racial minorities gained undeserved advantage longer discriminated even counter stereotypic leaders president obama racial ethnic minority groups elected positions authority subject tokenism heightened visibility racialized scrutiny media ways reinforce cultural stereotypes current study uses participants experiment examine exposure positive versus negative news frames obama differential effects white participants symbolic racist beliefs priming perspective exposure negative frames president obama likely activate underlying prejudicial feelings lead biased evaluations african americans whole using path analysis present study builds causal chain relationships reveals exposure negative news frames obama compared positive ones activates readers anti black affect turn increases symbolic racist beliefs implications findings race ethnic studies political communication journalism discussed
long term levodopa therapy patients parkinson disease associated motor complications including motor fluctuations levodopa induced dyskinesias lid time appearance lid apparently related timing duration levodopa therapy highly variable performed retrospective analysis levodopa treated patients explore effect time onset levodopa initiation time lid used cox multivariate regression model stratifying patients four quartiles according time levodopa initiation data patients males age onset years time levodopa treatment months included analysis early levodopa administration associated shorter time diagnosis lid hazard ratio develop lid time diagnosis respectively population found delaying levodopa administration associated longer time appearance motor complications diagnosis disease duration important determinant onset motor complications delaying levodopa could prolong complication free period
dietary potassium may neutralize acid load reduce calcium loss bone leading beneficial effect bone mineral density nationwide korean population study dietary potassium intake associated improved bone mineral density older men postmenopausal women nutrition major modifiable factor affects bone health accompanying anion dietary potassium may act alkaline source neutralizing acid load reducing calcium loss bone aimed evaluate association dietary potassium intake bone mineral density bmd korean population analyzed total men aged years postmenopausal women korean national health nutrition examination survey knhanes lumbar spine total hip femur neck bmd measured using dual energy ray absorptiometry daily food intake assessed using food frequency questionnaire divided participants tertiles based intake potassium intake highest potassium intake tertile group showed significantly higher total hip femur neck bmd compared lower tertile groups day across tertiles total hip day femur neck postmenopausal women highest potassium intake tertile group showed significantly higher lumbar total hip femur neck bmd compared lower potassium intake tertile groups day across tertiles lumbar spine day total hip day femur neck dietary potassium intake positively associated bmd men aged years postmenopausal women indicating beneficial effects dietary potassium intake bone health
retrospective study designed investigate incidence clinical characteristics prognosis corneal perforation patients fungal keratitis clinical data patients diagnosed fungal keratitis air force general hospital obtained retrospective study participants divided corneal perforation non perforation groups pathogenesis etiological characteristics admission date clinical symptoms statistically compared two groups clinical prognosis patients presenting corneal perforation retrospectively analysed incidence rate corneal perforation patients fungal keratitis statistical significance noted two groups terms history corneal trauma contact lens wear ocular surface diseases proportion patients topically administered glucocorticoid chi complicated diabetes mellitus chi considerably differed two groups type pathogenic fungus duration onset admission significantly differed two groups fungal keratitis patients administered glucocorticoid complicated diabetes mellitus higher risk corneal perforation compared counterparts type pathogenic fungus admission date size infiltration depth corneal lesion hypopyon probably served risk factors incidence corneal perforation patients diagnosed fungal keratitis
automatic detection salient objects images gained popularity computer vision field usage numerous vision tasks recent years depth information plays important role human vision system underutilized existing two dimensional saliency detection methods letter multistage salient object detection framework via minimum barrier distance transform saliency fusion based multilayer cellular automata mca proposed first independently generate spatial prior depth bias rgb produced depth induced saliency maps next two saliency maps weighted depth bias obtain two initial maps adopt saliency optimization step generate precise depth induced saliency map moreover initial rgb produced optimized depth induced maps fused spatial prior finally utilize mca fuse saliency maps generated previously obtain final saliency result complete salient object proposed method evaluated publicly available benchmark dataset rgbd compared several state art depth aware approaches experimental results demonstrate effectiveness superiority method accurately detect salient objects rgb images satisfactory overall performance
paper presents improved version wireless device embedded smart pzt sensor detect flaws structural defects selected investigated structure smart pzt sensors used actuator sensor coupled two xbee one signal generator chip programme execution transmitting receiving ultrasonic guided wave via pzt sensor written matlab developed source code basically receive serial data one xbee another remote xbee attached investigated structural system refined waveform response utilised prognosis true structural status simulated holed one aluminium structural plate benchmarked pristine condition validating effectiveness developed shm wireless module results showed wave even non defected area disrupted affected area ultrasonic waves increase continuously non destructive evaluation structural health monitoring various structural applications guided wave propagate long distances reach difficult access regions inspecting porous non porous materials ultrasonic waves attenuate fast useful recent advances ultrasonic wave application model results discussed paper
paper compares performance popular adaptive refinement technique finite element method fem adaptive version recently presented operator customized wavelet basis ocwb new method combination second generation wavelet theory hierarchical basis multi resolution basis applied fem solution split different levels detail levels also referred scales composed compactly supported functions allowing detail added chosen regions although strategy reduces total system dimension sufficiently small error scales naturally coupled means interactions functions composing different detail levels coupling forces whole multi resolution system recomputed detail added kind redundancy also occurs method using second generation wavelet theory functions custom designed decouple system means interactions functions different levels eliminated possible solve detail independently previous scales property significantly increases performance algorithm conversely formulation consequently algorithm design complexity also increased reason applications subject like method adaptive ocwb programmed various strategies since results shown terms processing time regular algorithms developed similar structures
carbon nanotubes dispersed polymer matrix aligned form fibers interconnects cured electrically light conductivity effective semiconductor tunneling reverse forward bias field designed differentiable current voltage response fiber channel current voltage response function strain applied fibers along axial direction biaxial shear strains correlated differentiating signals aligned fibers channels using small doping magnetic nanoparticles composite fibers magneto resistance properties realized strong enough use resulting magnetostriction state variable signal processing computing various basic analog signal processing tasks addition convolution filtering etc performed preliminary study shows promising application concept combined analog digital computation carbon nanotube based fibers various dynamic effects relaxation electric field dependent nonlinearities hysteresis output signals studied using experimental data analytical model
employment embedded cameras navigation guidance unmanned aerial vehicles uav attracted focus many academic researches particular multirotor uav camera widely employed applications performed indoor environments gnss signal often unreliable electromagnetic interference concern literature images mostly adopted position velocity estimation rather attitude estimation paper proposes attitude determination method multirotor aerial vehicles using pairs vector measurements taken downward facing strapdown camera method composed three modules first one detects identifies visible landmarks processing images second module computes vector measurements related direction camera landmarks third module estimates attitude vector measurements last module version multiplicative extended kalman filter mekf sequential update proposed estimation method overall method evaluated via monte carlo simulations showing effective determining vehicle attitude revealing properties
last decades increasing attention environmental issues come fore due looming issue climate change growing demand energy coupled increasing greenhouse gas ghg emissions forced study development energy plants use renewable energy sources res electricity generation one major contributors anthropogenic emissions small hydropower plants particular interest potential assumed high aim study provide comprehensive assessment environmental impacts small hydropower plants shps using life cycle assessment lca methodology main parameter set simplified lca model weight components used construct operate plant concrete aggregates steel lca air pollutant externalities associated life cycle shps accomplished applying needs framework results given per impact type human health loss biodiversity crop yield material damage climate change spearhead study environmental cost must parameter total investment cost may affect indexes financial evaluation project
efficient way construction industry approach sustainability reuse waste materials products industrial activities research lower oxford clay loc combined pulverised fly ash pfa target materials stabilised lime portland cement blended binders comprising lime blended ground granulated blast furnace slag ggbs technological economic well environmental advantages potential utilising pfa industrial product coal industry ggbs product steel industry development eco friendly clay pfa building bricks need sustainability reduction material processing costs reduction firing costs well established within construction industry recycling ggbs pfa admixtures nowadays much alternative reducing costs view huge demand building bricks along non availability suitable soil need explore alternative raw materials energy efficient technologies making bricks whose final pricing relatively low results based pilot industrial commercial trials research illustrated key parameters compressive strength environmental properties within acceptable engineering standards masonry units environmental sustainability analysis results unfired loc pfa brick shown energy efficiency suggests remarkable economical alternative firing building materials new technologies invention enhanced waste management use eco friendly building materials great contribution concept green building elsevier ltd rights reserved
backgroundno consensus exists regarding use radiotherapy conjunction high dose chemotherapy autologous stem cell transplantation hdc asct patients relapsed refractory classical hodgkin lymphoma objectives current study characterize practice patterns assess efficacy toxicity major transplantation centers methodseligible patients underwent hdc asct using combination either carmustine bcnu etoposide cytarabine melphalan beam cyclophosphamide bcnu etoposide cbv resultsfor cohort patients year overall survival rate progression free survival rate local control rate used within months asct patients given often disease early stage primary refractory fluorodeoxyglucose fdg avid time hdc asct disease recurrence occurring hdc asct associated primary refractory disease fdg avidity time hdc asct found associated progression free survival overall survival univariate analysis model incorporating primary refractory fdg avid disease time hdc asct found associated decreased risk local disease recurrence hazard ratio patients primary refractory fdg avid disease time hdc asct year rate versus without one case common terminology criteria adverse events grade related toxicity acute grade pancytopenia conclusionsin patients undergoing asct relapsed refractory peritransplantation used often disease early stage primary refractory fdg avid salvage conventional dose chemotherapy associated improved high risk localized disease well tolerated modern techniques cancer american cancer society multi institutional cohort patients underwent autologous stem cell transplantation relapsed refractory hodgkin lymphoma peritransplantation radiotherapy used often disease early stage primary refractory fluorodeoxyglucose avid salvage conventional dose chemotherapy radiotherapy associated improved local control high risk localized disease well tolerated modern techniques
smartphones become ubiquitous society large number users spending time sharing personal data devices would beneficial gain understanding data security paper presents different security issues regarding applications android systems one popular mobile operating systems research also sheds light public feels number privacy security issues related permissions whether additional factors play individual understanding application permission framework
load balancing algorithms task scheduling one important tasks parallel application design implementation proper task assignment processor cores minimize execution time increase performance parallel application paper propose combined load balancing algorithm based mixture well known domain decomposition master slave algorithms proposed algorithm minimizes load imbalance communication independent tasks proposed algorithm improved parallel efficiency using task rescheduling confirmed simulation results
report dft studies perylene based dyes electron transfer properties solar cell applications study involves modeling different donor acceptor type sensitizers perylene donor furan pyrrole thiophene bridge cyanoacrylic group acceptor effect different bridges various substituents perylene donor evaluated terms opto electronic photovoltaic parameters homo lumo energy gap lambda max light harvesting efficiency lhe electron injection efficiency empty set inject excited state dye potential dye reorganization energy lambda free energy dye regeneration delta dye regen effect various substituents dye interaction hence recombination process also evaluated found furan based dimethylamine derivative exhibits better balance various optical photovoltaic properties finally evaluated overall opto electronic transport parameters tio dye assembly anchoring dyes model tio cluster assembly
space cooling buildings responsible substantial portion energy consumption greenhouse gas emission order reduce building energy consumption reflective coatings adopted extensively since effectively minimize undesirable solar energy absorption paper functional additives titanium dioxide hollow glass beads used improve reflective insulation properties thermal coating materials thermal impact upon application different reflective coatings concrete panels experimentally examined experimental results shown coating containing titanium dioxide hollow glass beads leads drop interior surface temperature degrees implying coating effectively reduce heat absorption cooling load buildings finite difference time domain simulation fdtd simulate propagation electromagnetic waves used investigate reflection electromagnetic waves explore working principles additives numerical simulations demonstrate reflective behavior coating material showing embedded tio nanoparticles significantly improve reflective performance coating films envisioned nontoxic coating high level reflectance insulation characterized working principles different additives revealed elsevier rights reserved
referential integrity one three inherent integrity rules enforced databases using foreign keys however many real world applications referential integrity enforced since foreign keys remain disabled ease data acquisition important applications anomaly detection data integration data modeling indexing reverse engineering schema design query optimization benefit discovery foreign keys therefore profiling foreign keys dirty data important yet challenging task raise challenge diverting previous research null markers ignored propose algorithms profiling unary multi column foreign keys real world different semantics null markers sql standard state art algorithms perform well absence null markers shown perform poorly presence extensive experiments demonstrate algorithms perform well real world state art algorithms perform idealized special case null markers ignored
background despite claims millennium development goals mdg targets access safe drinking water met many millions people still access challenge remains provide people especially young children safe drinking water method report longitudinal study designed assess effectiveness intervention based provided treated drinking water containers self reported diarrhoea children intervention fontaines pour demain non governmental profit organization created based caluire france helps local entrepreneurs treat package sell safe drinking water cases controls chosen village household level propensity score matching participants visited twice month six months asked complete diarrhoea health diary results total follow visits completed participants homes diarrhoea reported children visit equating incidence rate estimate episodes per child per year confidence interval compared drinking water children drinking surface water drinking protected ground water drinking bottled water likely report diarrhoea children drinking harvested rainwater similar rates diarrhoea children drinking water conclusion study suggests water provides safer alternative groundwater surface water furthermore study raises serious concerns validity assuming protected groundwater safe water purposes assessing mdg targets contrast study provides addition evidence relative safety rainwater harvesting
background interpersonal stress generation important maintaining factor major depression however little known psychological mechanisms undermine interpersonal functioning study investigated role deficits person perception regard method depressed patients healthy controls completed false recognition task measured participants tendencies make spontaneous trait inferences stis spontaneously ascribe personality traits people participants reported interpersonal daily hassles one week following task results tendencies make stis significantly higher depressed patients particularly history childhood trauma degree participants made stis significantly related depression severity predicted occurrence interpersonal daily hassles follow across within groups conclusions results suggest depressed patients show characteristic biases person perception may contribute generation interpersonal stress
geosynthetic reinforced soil walls accepted technology solution earth retaining problems due cost savings easy quick construction associated environmental benefits additional savings reduction environmental impact realised using recycled construction demolition waste rcdw backfill material paper describes two structures built full scale instrumented one walls reinforced woven polyester geogrid wall wall relatively extensible nonwoven polypropylene geotextile walls constructed using rcdw backfill material built foundation soil prone fabric collapse due increased stress increase moisture content monitoring period walls subjected rainy season followed induced inundation foundation trigger soil fabric collapse results showed foundation soil collapse influenced wall behaviour geosynthetic type exception similar performance local face bulging greater wall geotextile extensible reinforcement unconfined conditions wall geogrid expected moving formwork construction method however directly behind wall face reinforcement material types confined horizontal displacements similar addition locations beyond half wall base length strain distributions low less walls practical conclusion study wrap face appearance end construction concern large bulging wall performance unaffected choice reinforcement types used investigation
magnetic resonance enterography mre accurate examination assessing activity crohn disease various mre indices developed purpose directly compared aim study compare diagnostic accuracy three mre indices detecting grading disease activity using endoscopy gold standard mre ileocolonoscopies performed within month patients analyzed magnetic resonance index activity maria clermont london indices colonic segment terminal ileum calculated simplified endoscopy score ses considered gold standard two hundred twenty four intestinal segments included analysis according established cut points detecting active disease using maria clermont london indices sensitivity index specificity respectively sensitivity detecting ulcerations maria clermont indices respectively specificity auroc curve maria clermont london indices detecting active disease detecting ulcerations maria clermont index three mre based indices evaluated current study high diagnostic accuracy assessment disease activity maria index best operational characteristics detecting disease activity also grading severity supports use clinical studies clinical practice
widely adumbrated patterns parallel computation communication algorithmic skeletons introduce viable solution efficiently programming modern heterogeneous multi core architectures equipped traditional multi core cpus also one programmable graphics processing units gpus systematically applying algorithmic skeletons address complex programming tasks arguably possible separate coordination computation parallel program therefore subdivide complex program building blocks modules skids components independently created used different systems drive multiple functionalities exploiting systematic division feasible automate coordination addressing extra functional non functional features application performance portability resource utilisation component level heterogeneous multi core architectures paper introduce novel approach exploit inherent features skeleton based applications order automatically coordinate heterogeneous cpu gpu multi core architectures improve performance systematic evaluation demonstrates one order magnitude speed heterogeneous multi core architectures
peptide nucleic acid fluorescence situ hybridization pna fish highly specific molecular method widely used microbial identification nonetheless due detection limit technique time consuming preenrichment step typically required identification developed lab chip device concentrate cell suspensions speed identification process yeasts pna fish protocol optimized target saccharomyces cerevisiae common yeast relevant several types food industries several coinsized microfluidic devices different geometries developed using computational fluid dynamics cfd modeled hydrodynamics inside microchannels selected promising options structures fabricated based selected designs used produce polydimethylsiloxane based microchips soft lithography result integrated approach combining microfluidics pna fish rapid identification cerevisiae achieved improve fluid flow inside microchannels pna fish labeling oxygen plasma treatment applied microfluidic devices new methodology introduce cell suspension solutions microchannels devised strong pna fish signal observed cells trapped inside microchannels proving proposed methodology works intended microfluidic designs pna fish procedure described easily adaptable detection microorganisms similar size
purpose traditionally since neer humeral side shoulder arthroplasty consisted stemmed component real need stem fixation total shoulder arthroplasty tsa barely investigated current study evaluated clinical radiological outcomes stemless tsa methods forty seven patients female male patients average age selected four orthopaedic centres four year period implanted humeral head prosthesis three fin design titanium coating aetiologies primary osteoarthritis fracture sequelae avascular osteonecrosis minimum follow two years range months patients evaluated constant score radiological exams results two patients revision implants one persistent pain one secondary massive rotator cuff tear final follow mean average gain parameters improved foremost pain relief mean satisfaction rate average anterior active elevation degrees gain radiologic evaluations showed stable implants cases however cases demonstrated radiolucent areas particularly superior lateral implant neither decreased increased time revisions related humeral component loosening conclusions stemless tsa provides results compared tsa humeral stem still unsure nature lucent zones continuing investigation better understand radiological phenomenon
clinical laboratory identification underlying risk respiratory illness athletes proved problematic aim study determine whether clinical data combined immune responses standardised exercise protocols genetic cytokine polymorphism status could identify risk respiratory illness symptoms cohort highly trained athletes male endurance athletes max min underwent clinical evaluation known risk factors physician comprehensive laboratory analysis immune responses rest two cycling ergometer tests min max long min intervals max intense blood tests performed determine epstein barr virus ebv status dna genotyped panel cytokine gene polymorphisms saliva collected measurement iga detection ebv dna athletes followed months self reported episodes respiratory illness confirmation underlying cause sports physician associations risk respiratory illness identified parameter assessed clinical evaluations laboratory parameters associated increased risk respiratory illnesses highly trained athletes cytokine gene polymorphisms high expression ifn gamma expression ebv dna saliva low levels salivary iga concentration genetic risk score developed cumulative number minor alleles cytokines evaluated athletes prone recurrent respiratory illness likely immune disturbances allow viral reactivation genetic predisposition pro inflammatory cytokine responses intense exercise
purpose study evaluate current literature use weighted vests individuals autism spectrum disorder asd literature review using standards recommended works clearinghouse conducted studies included review met following criteria use single case research design inclusion least one individual asd examination effects particular dependent variable publication english peer refereed journal past years results review show use individuals asd evidence based practice elsevier ltd rights reserved
chronic obstructive pulmonary disease copd major health problem increasing morbidity mortality growing literature regarding extra pulmonary manifestations copd significant impact symptom burden disease progression anaemia one recently identified morbidities prevalence varies depending patient characteristics diagnostic criteria used systemic inflammation seems important factor establishment repeated bursts inflammatory mediators copd exacerbations could inhibit erythropoiesis however renal impairment malnutrition low testosterone levels growth hormone level abnormalities oxygen supplementation theophylline treatment inhibition angiotensin converting enzyme aging additional factors could associated development anaemia present review evaluates published literature prevalence significance anaemia copd moreover attempts elucidate reasons high variability reported investigates complex pathophysiology underlying development anaemia patients
autism spectrum disorder asd characterized impairments social communication well restricted repetitive behaviors evidence suggests individuals asd cognitive impairments related weak central coherence hyperrestricted processing reducing noradrenergic activity may improve aspects network processing thus improve cognitive abilities verbal problem solving individuals asd present pilot study explores effects acute administration beta adrenergic antagonist propranolol verbal problem solving adults adolescents asd within subject crossover design participants asd received single dose propranolol placebo one two sessions double blinded counterbalanced manner verbal problem solving assessed via anagram task baseline measurements autonomic nervous system functioning obtained anxiety assessed baseline following drug administration participants solved anagrams quickly propranolol condition compared placebo condition suggesting potential cognitive benefit agent additionally observed negative linear relationship response propranolol anagram task two measures baseline autonomic activity well positive linear relationship drug response baseline anxiety relationships propose potential markers treatment response propranolol influences autonomic functioning anxiety investigation needed expand present single dose psychopharmacological challenge explore observed effects propranolol serial dose setting
research development novel software support production management construction requires testing application impact crew leaders task allocation decisions given difficulties isolating cause effect field experiments inadequacy discrete event simulations dess purpose evaluating crew leaders experience performance novel experimental approach sought would provide benefits des would nevertheless allow observation behavioral aspects hybrid virtual construction site vcs system devised implemented construction crew leaders immersed virtual reality automated virtual environment worked des controlled site without prototype system object research vcs proved efficacy allowing researchers observe record analyze decision making behavior human subjects controlled environment high accuracy relatively short times american society civil engineers
malformed young satsuma mandarin citrus unshiu marc fruits found xunwu county jiangxi province china common disease symptoms include slightly curled backward twisted spring leaves cracked deformed leaf edges thickly grown spring twigs twisted slightly bent shoots malformed young fruits groovelike depression forms upper portion resembles pumpkin basis morphological characteristics sequencing results phylogenetic analysis infected plant identified disease citrus yellow vein clearing caused citrus yellow vein clearing virus cyvcv knowledge study first report cyvcv infecting satsuma mandarin
tracing allows analysis task interactions operating system locating performance problems trace trivial large size furthermore deep knowledge components observed system required decide whether observed behavior normal introduce tracecompare framework automatically identifies differences groups executions task user space kernel levels many performance problems manifest variations easily identified framework comparison algorithm takes account threads affect completion time analyzed executions differences correlated application code facilitate correction identified problems performance characteristics task executions represented new data structure called enhanced calling context tree ecct demonstrate efficiency approach presenting four case studies tracecompare used uncover serious performance problems enterprise open source applications without prior knowledge codebase also show overhead tracing solution percent depending type application
aims normal tissue complication probability ntcp model severe acute mucositis would highly useful guide clinical decision making inform radiotherapy planning aimed improve upon previous model using novel oral mucosal surface organ risk oar place oral cavity oar materials methods predictive models severe acute mucositis generated using radiotherapy dose oral cavity oar mucosal surface oar clinical data penalised logistic regression random forest classification rfc models generated oars compared internal validation carried iteration stratified shuffle split cross validation using multiple metrics assess different aspects model performance associations treatment covariates severe mucositis explored using rfc feature importance results penalised logistic regression rfc models using oral cavity oar performed least well models using mucosal surface oar associations dose metrics severe mucositis similar mucosal surface oral cavity models volumes oral cavity mucosal surface receiving intermediate high doses strongly associated severe mucositis conclusions simpler oral cavity oar preferred mucosal surface oar ntcp modelling severe mucositis recommend minimising volume mucosa receiving intermediate high doses possible royal college radiologists published elsevier ltd
purpose aim study explore breast cancer survivors experience weight loss intervention identify potential facilitators barriers initiating maintaining weight dietary physical activity changes method fourteen women randomised completing month weight loss intervention completed semi structured interviews months intervention completion inductive thematic analysis conducted whereby interviews independently coded themes identified results women mean years months post diagnosis study baseline four themes emerged perceived motivation participate intervention facilitators challenges maintenance weight loss behaviour changes women noted impact social family environments either facilitate support family members impede major family event changes structure support intervention particularly accountability coach also seen facilitating formation habitual physical activity facilitated dietary changes dietary change strategies perceived facilitate weight loss reducing energy intake dietary self monitoring increasing vegetable intake portion control challenges included breast cancer specific issues post diagnosis weight gain treatment related side effects psychological issues around readiness change self regulation diminished accountability following intervention completion impacted maintenance weight loss behaviour changes notably dietary self monitoring conclusions results suggest formal involvement support person family member friend referring women ongoing community based services maintain patient perceived accountability may particularly useful strategies future weight loss intervention trials targeting women breast cancer
scheduling lithium ion batteries energy storage applications power systems requires accurate estimate state charge soc coulomb counting method popular industry remains inaccurate paper presents intelligent technique soc estimation lithium ion batteries model developed offline using adaptive neuro fuzzy inference systems anfis considers cell nonlinear characteristics supplied manufacturer provide relationship cell soc open circuit voltage ocv different temperatures manufacturer data used model cell characteristics anfis order yield cell soc arbitrary ocv temperature within given range pack soc accordingly estimated purposes comparison coulomb counting method used cell level rather pack level estimate soc battery laboratory experiments conducted kwh battery module measured soc compared coulomb counting computations cell pack levels results show distinct superiority proposed anfis technique traditional coulomb counting method elsevier ltd rights reserved
aim investigate relationship anomalous self experiences duration untreated psychosis sample patients first episode schizophrenia spectrum disorders methods anomalous self experiences assessed means examination anomalous self experience manual patients referred first adequate treatment schizophrenia diagnoses symptom severity functioning childhood trauma assessed using structured clinical interview positive negative syndrome scale premorbid adjustment scale social functioning scale childhood trauma questionnaire substance misuse measured drug use disorder identification test alcohol use measured alcohol use disorder identification test duration untreated psychosis measured accordance standardized procedure results high levels anomalous self experiences significantly associated longer duration untreated psychosis association held correcting variables associated long duration untreated psychosis conclusions field early detection psychosis need additional clinical perspectives make progress improved understanding assessment anomalous self experiences may help clinicians detect important phenomena provide earlier help thus reduce treatment delay
significant progress contraception particular emergency contraception made past decade emergency contraception first introduced stand alone prescription interaction politics medicine meant tumultuous course drug becoming available counter article reviews emergency contraception works effectiveness different methods pros cons history emergency contraception
building upon previously published life cycle assessment lca methodologies conducted lca commercial rainwater harvesting rwh system compared municipal water supply mws system adapted washington eleven life cycle impact assessment lcia indicators assessed functional unit rainwater municipal water delivery system toilets urinals four story commercial building employees assessment shows benchmark commercial rwh system outperforms mws system categories except ozone depletion sensitivity performance analyses revealed pump pumping energy key components categories guides lcia tradeoff analysis respect energy intensities tradeoff analysis revealed commercial rwh performed better mws ozone depletion rwh energy intensity less mws least kwh benchmark mws energy usage kwh rwh also outperformed mws metal depletion freshwater withdrawal regardless energy intensities kwh auxiliary commercial rwh system mws reduced ozone depletion showed increase impacts still lower benchmark mws system impacts current models transferrable commercial rwh installations locations published elsevier ltd
traditional training program assessment requirements evaluation criteria already meet requirements college students new era characteristics course mechanical engineering control base course abstract subject highly crossed basis study current situation college students characteristics course summary training program evaluation method course trinity training model combining closed book exam matlab computer examination school homework study presented paper mode develops useful discards changes way students learn course simple understanding practice cognition plays certain role promoting students learning enthusiasm interest cultivation application ability construction knowledge system
mouse collagen induced arthritis cia commonly used animal model investigate underlying pathogenesis autoimmune arthritis demonstrate therapeutic efficacy novel drugs autoimmune arthritis conventional read outs cia clinical score histopathology several limitations including subjected observer bias longitudinal therapeutic efficacy new drug determined thus robust non invasive vivo drug screening tool currently unmet need assessed utility fluorodeoxyglucose positron emission tomography fdg vivo screening tool anti inflammatory drugs using mouse cia model radiotracer fdg pet scanner employed monitor cia disease activity murine anti tumour necrosis factor tnf alpha antibody cnto therapy mouse cia model radiotracer concentration derived pet images individual limb joints per limb basis spearman correlation coefficient rho determined clinical score histology affected limbs cnto improved arthritis efficiently evidenced clinical score histopathology pet showed increased uptake fdg progression disease significant decrease post treatment group fdg uptake patterns showed strong correlation clinical score rho histopathology rho study demonstrates potential fdg pet tool vivo drug screening inflammatory arthritis monitor therapeutic effects longitudinal setting
parkinson disease dementia lewy bodies dlb multiple system atrophy msa three major synucleinopathies characterized alpha synuclein containing inclusions brains patients cell types brain structures affected vary markedly disorders patients different clinical manifestations addition overlapping symptoms basis differential diagnosis cognitive impairment depression associated hippocampal dysfunction frequently observed disorders various alpha synuclein containing inclusions found hippocampal formation increasing evidence supports small alpha synuclein aggregates oligomers may real culprit causing deficits neurotransmission neurogenesis hippocampus related brain regions constitute major mechanism hippocampal dysfunctions associated neuropsychiatric manifestations synucleinopathies
sleep complaints reported menopausal women poor sleep risk factor cardiovascular disease diabetes obesity effect menopausal hormone therapy sleep quality unclear systematic review meta analysis conducted summarize efficacy menopausal hormone therapy self reported sleep quality electronic databases pubmed scopus ovid medline embase ebm reviews central psycinfo searched october randomized trials assessing effect menopausal hormone therapy minimum follow weeks included titles abstracts full texts screened independently duplicate primary outcome included sleep items within questionnaire scale diary standardized mean differences across trials pooled using random effects models search identified articles trials included seven trials moderate high risk bias enrolling women pooled meta analysis menopausal hormone therapy improved sleep quality women vasomotor symptoms baseline standardized mean difference moderate quality evidence difference noted women without symptoms analyzed separately combined across sleep quality questionnaires daytime dysfunction evaluated sleep domain menopausal hormone therapy improves sleep women concomitant vasomotor symptoms heterogeneity trials regarding study population formulations sleep scales limit overall certainty evidence future menopausal hormone therapy trials include assessment self reported sleep quality using standardized scales adhere reporting guidelines
gasification promising alternative polymeric waste valorization mechanical recycling unfeasible account heterogeneity partial contamination simply yields product lower quality market requires apart application electricity generation waste derived syngas shows great potential chemical waste recycling synthesis hydrogen methane natural gas methanol spite effort devoted far experimental demonstration processes enable technology access commercial stage still necessary develop detailed models process allow precise prediction resulting syngas composition well tar formation global efficiency process research work presents development polyolefin gasification model fluidized bed reactors model details behaviour primary pyrolysis homogeneous reactions oxidation steam reforming aromatization thermal cracking accomplish adopts new modelling strategies definition primary tar species order reflect twofold nature aliphatic aromatic well describe kinetics stoichiometry involved thermal cracking processes tar species model able successfully predict generation volume composition heating value syngas final tar generation global efficiency process elsevier ltd rights reserved
paper analyzes impacts flexible demands day ahead market outcomes system significant wind power production use two stage stochastic market clearing model first stage represents day ahead market second stage represents real time operation one hand flexibility demands beneficial system whole since flexibility reduces operation cost hand shifts demands peak periods peak periods may influence prices way demands may willing provide flexibility specifically investigate impacts different degree demand flexibility day ahead prices number scenarios modeling uncertainty associated wind production operation stage nonconvexities due start costs generators minimum power outputs taken account
job scheduling strategy rendering studied according scheduling model heterogeneous cluster rendering system work proposed job scheduling strategy heterogeneous cluster rendering follows definition load balancing measurement influencing factors model construction job scheduling model based cluster rendering dynamic algorithm design based genetic algorithm heterogeneous cluster rendering system achieved effective scheduling algorithm load balancing simulation results showed algorithm good load balancing work proposes theoretical basis new idea resource scheduling cluster system cloud platform well support effective use resources great significance
objectives evaluate whether sling position associated particular types complications patients undergoing suburethral sling placement stress urinary incontinence methods data women diagnosed evangelical hospital hagen haspe complications suburethral sling insertion analyzed patients underwent pelvic floor ultrasound assess urethral length sling location relation urethral length sling distance longitudinal smooth muscle complex urethra sling longitudinal smooth muscle distance results shortest median sling longitudinal smooth muscle distance observed patients recurrent urinary tract infections urinary retention overactive bladder respectively women persistent stress urinary incontinence sling erosion sling longitudinal smooth muscle distance respectively persistent stress urinary incontinence connected position sling relation bladder neck patients sling closer bladder neck conclusions sling location plays pivotal role occurrence certain complications sling position proximal part urethra middle proximal urethra appears connected high rate unsuccessful stress urinary incontinence treatment sling longitudinal smooth muscle distance often connected sling complications overactive bladder urinary retention recurrent urinary tract infections
introductionemergency contraception must followed use effective method contraception order reduce future risk unintended pregnancies provision long acting reversible contraception larc highly effective regard aim study compare use effective method contraception months following insertion copper intrauterine device iud intake ulipristal acetate upa emergency contraception material methodswomen presenting need outpatient midwifery clinic chose either iud upa according preference follow months later telephone interviews primary outcome use effective contraceptive method month follow secondary outcomes included use effective contraceptive method months follow acceptability iud resultsa total women opted iud used effective contraceptive method months first visit compared women opted upa iud group still using iud months stated would recommend iud others method conclusionsignificantly women chose iud used effective method contraception month follow results study support increased use iuds
paper presents features functions software tool called fatigue prediction utility abaqus cae fpu designed plugin abaqus commercial code allowing fatigue predictions based results abaqus analyses also contains interface data transfer abaqus pragtic standalone fatigue post processor program contains simple intuitive graphical interface makes preparation fatigue analysis straightforward fpu fatigue solver may executed multiple cpu cores independently abaqus cae allows large scale problems solved server machines reasonable time overview functionality plugin available prediction models concept data exchange abaqus pragtic given illustrative examples given appropriate order introduce features tool possible ways adapting code interconnection solver abaqus discussed elsevier ltd rights reserved
objectives primary risk factors necrotizing enterocolitis nec preterm birth enteral feeding gut colonization unclear whether feeding colonization induce excessive expression immune genes lead nec using pig model hypothesized reduced gestational age would upregulate immune related genes cause bacterial imbalance birth methods preterm gestation near term gestation pigs delivered cesarean section euthanized birth days infant formula bovine colostrum feeding results birth preterm delivery reduced intestinal genes related nutrient absorption innate immunity relative near term pigs whereas genes upregulated preterm birth also reduced vivo intestinal glucose leucine uptake failed increase cytokine secretions intestinal explants relative near term birth days formula feeding nec incidence increased preterm versus near term pigs total genes related immunity tlr ilb permeability cldn ocln absorption sglt decreased pretermpigs without affecting gram negative bacteria related responses tlr ikba nfkb tnfaip pafa bacterial abundance tended higher preterm versus near term pigs whereas composition unaffected conclusions preterm birth predisposes nec reduces nutrient absorption induce upregulation immune related genes cause bacterial dyscolonization neonatal period excessive inflammation bacterial overgrowth may occur relatively late nec progression preterm neonates
serotonin widely studied neurotransmitter plays important role development proper functioning organism throughout life appearance system early ontogeny suggests hypothesis plays regulatory role neurodevelopment study investigated effect administration tryptophan deficient diet prenatal development morphology cell population dorsal raphe experimental diet containing balanced amounts carbohydrates lipids proteins provided time mated group rats gestational day delivery control groups fed experimental diet formulation tryptophan added mixture regular chow diet delivery five pups per dam euthanized body brain weight measured brain sections processed immunohistochemistry tryptophan hydroxylase trph whole brain analysis sections containing dorsal raphe photographed light microscope trph positive neurons quantified brain weights tryptophan deprived group showed difference compared controls body weights reduced total numbers serotonergic neurons dorsal raphe prenatal tryptophan deficient pups reduced regional analysis dorsal raphe indicated marked cellular reduction medial caudal sections nucleus contains majority serotonergic neurons tryptophan deprived condition quantitative analysis showed brain concentration similar among conditions conclusion gestational tryptophan deprivation exerts adverse effects development system particularly dorsal raphe manifested decreased numbers serotonergic neurons well altered topography important nucleus isdn published elsevier ltd rights reserved
background hormone therapy widely provided control menopausal symptoms used management prevention cardiovascular disease osteoporosis dementia older women updated version cochrane review first published objectives assess effects long term least year duration mortality cardiovascular outcomes cancer gallbladder disease fracture cognition perimenopausal postmenopausal women cessation treatment search methods searched following databases september cochrane gynaecology fertility group trials register cochrane central register controlled trials central medline embase psycinfo searched registers ongoing trials reference lists provided previous studies systematic reviews selection criteria included randomised double blinded studies versus placebo taken least year perimenopausal postmenopausal women included oestrogens without progestogens via oral transdermal subcutaneous intranasal route data collection analysis two review authors independently selected studies assessed risk bias extracted data calculated risk ratios rrs dichotomous data mean differences mds continuous data along confidence intervals cis assessed quality evidence using grade methods main results included studies involving women derived nearly data two well conducted studies whi participants postmenopausal american women least degree comorbidity mean participant age studies years none studies focused perimenopausal women relatively healthy postmenopausal women generally fit without overt disease combined continuous increased risk coronary event year use per per venous thromboembolism year use per per stroke years use per per breast cancer years use per per gallbladder disease years use per per death lung cancer years use plus years additional follow per per oestrogen increased risk venous thromboembolism years use per per years use per per stroke years use per per gallbladder disease years use per per reduced risk breast cancer years use per per clinical fracture years use per per increase risk coronary events follow time women years age relatively healthy taking continuous combined showed increase incidence dementia years use per per among women cardiovascular disease use combined continuous significantly increased risk venous thromboembolism year use per per women taking significantly decreased incidence fracture long term use risk fracture outcome strong evidence showed clinical benefit derived years use combined per per years use oestrogen per per researchers found strong evidence clinically meaningful impact incidence colorectal cancer one trial analysed subgroups relatively healthy women years age taking combined continuous taking oestrogen versus similar sized placebo groups significantly increased risk reported venous thromboembolism women taking combined continuous absolute risk remained low less however differences risk excluded study designed power detect differences groups women within years menopause studies risk bias low domains overall quality evidence main comparisons moderate main limitation quality evidence women years old baseline age women likely consider vasomotor symptoms authors conclusions women intolerable menopausal symptoms may wish weigh benefits symptom relief small absolute risk harm arising short term use low dose provided specific contraindications may unsuitable women including increased risk cardiovascular disease increased risk thromboembolic disease obesity history venous thrombosis increased risk types cancer breast cancer women uterus risk endometrial cancer among women uterus taking oestrogen well documented indicated primary secondary prevention cardiovascular disease dementia prevention deterioration cognitive function postmenopausal women although considered effective prevention postmenopausal osteoporosis generally recommended option women significant risk non oestrogen therapies unsuitable data insufficient assessment risk long term use perimenopausal women postmenopausal women younger years age
interest robust automatic modal parameter extraction techniques increased significantly last years together rising demand continuous health monitoring critical infrastructure like bridges buildings wind turbine blades study novel multi stage clustering approach automated operational modal analysis aoma introduced contrast existing approaches procedure works without user provided thresholds applicable within large system order ranges used small sensor numbers place limitations damping ratio complexity system investigation approach works parametric system identification algorithm uses system order sole parameter data driven stochastic subspace identification ssi method used measurements wind tunnel investigation composite cantilever equipped fiber bragg grating sensors fbgss piezoelectric sensors used assess performance algorithm highly damped structure low signal noise ratio conditions proposed method able identify physical system modes investigated frequency range individual datasets using fbgss challenging signal noise ratio conditions better signal conditions two sensors elsevier ltd rights reserved
paper performance geogrid geotextile asphalt overlay delay rate reflective crack propagation studied based response surface methodology rsm tried investigate effect temperature crack width type geosynthetics polypropylene nonwoven glass grid interactions parameters reflective crack propagation accordance obtained results rsm equations presented predict high accuracy service life vertical crack growth rate initial strain using quadratic polynomial regression model addition new relationship initial strain temperature assembled based obtained results identified glass grid best effect improving overlay performance elsevier ltd rights reserved
paper contributes better understanding installation damage geosynthetics affect soil geosynthetic interaction pullout inclined plane shear effects installation damage induced field trials woven geotextile woven geogrid studied results indicated installation accumulation layer fine particles geosynthetic reduce skin friction available particularly sheet materials installation damage induce premature tensile failure pullout tests along unconfined portion geosynthetic causing significant reduction corresponding coefficient interaction contribution bearing members coefficient interaction pullout estimated using equations literature estimates optimistic installation damage induced little influence soil geosynthetic coefficient interaction inclined plane shear test different relative movements soil geosynthetic pullout inclined plane shear well deformation reinforcements pullout enabled different mobilisation interface strength comparable conditions tested coefficient interaction inclined plane shear tests larger measured pullout tests reduction factor installation damage obtained tensile tests overestimated effects installation conditions soil geosynthetic interface pullout inclined plane shear tests
hepatitis virus hcv infection major health problem egypt nation bears highest prevalence rate worldwide necessitated establishing novel model care moc contain epidemic deliver patient care ensure global treatment access review describe process development egyptian model future strategies sustainability although magnitude hcv problem known many years hcv moc came establishment national committee control viral hepatitis nccvh set implement national control strategy disease causes viral hepatitis strategy outlines best practices patient care delivery applying set service principles identified clinical streams patient flow continuums egyptian national viral hepatitis treatment programme considered one successful effective public health programmes date one million patients evaluated received treatment umbrella programme since nccvh successful establishing strong infrastructure controlling viral hepatitis egypt established nationwide network digitally connected viral hepatitis specialized treatment centres covering country map enhance treatment access practice guidelines suiting local circumstances issued regularly updated applied affiliated centres review illustrates model successful egyptian experience sets exemplar states organizations policy makers setting programmes care management people hepatitis
purpose examine complications arthroscopic knee surgeries conducted sports medicine knee center hospital subjects methods prospective study total patients men women underwent arthroscopic knee surgeries center january march years months studied ages surgery ranged years mean years arthroscopy conducted sports injuries patients main diagnoses included meniscal injury patients discoid meniscus patients anterior cruciate ligament injury knees posterior cruciate ligament injury knees loose body knees intraarticular fracture knees arthroscopic procedures included meniscectomy knees meniscal suture repair knees anterior cruciate ligament reconstruction knees intraoperative postoperative complications cases investigated results rate complication cases intraoperative complications comprised three cases intraarticular instrument breakage one case meniscal injury postoperative complications consisted two cases septic arthritis one case superficial infection reoperation necessary two cases septic arthritis neural vascular ligament injuries surgery complex regional pain syndrome symptomatic deep vein thrombosis pulmonary embolism observed conclusion arthroscopic knee surgeries considered minimally invasive conducted relatively safe low complication rates series however seven cases complications occurred including two cases septic arthritis furthermore symptomatic thromboembolism reported occur also arthroscopic surgery risk severe complications acknowledged
background dry skin xerosis cutis increasingly recognized relevant health problem daily life health nursing care use bath additives oils common reduce dry skin empirical evidence supporting practice limited objectives aim study investigate effectiveness using bath oil additive improving skin barrier function ameliorating dry skin comparison non oil containing skin cleansers bathing showering design single centre randomized observer blind pragmatic parallel group trial settings outpatient community care participants volunteers showing clinically mild moderate dry skin recruited city berlin methods healthy children adults randomly assigned use either commercially available bath oil continue using regular non oil containing skin cleansers every day study period days skin barrier parameters severity dry skin assessed baseline two follow visits study centre transepidermal water loss primary outcome results sixty participants randomized completed trial median age iqr years end study mean transepidermal water loss intervention group statistically significant lower compared control group mean difference stratum corneum hydration statistically significantly higher intervention group end study skin surface roughness comparable groups remained unchanged groups showed trend improvement dry skin symptoms conclusions pragmatic trial provides empirical evidence regular use investigated bath oil effective improving skin barrier function children adults mild dry skin used routine skin care supports use basic element management broad spectrum dry skin conditions elsevier ltd rights reserved
background rostral prefrontal cortex rpfc involved reflective thought processes self knowledge person perception hypothesized childhood emotional abuse disruptive emotional regulation would differentially impact neurometabolite concentrations rpfc related neocortical areas adults generalized anxiety disorder gad versus healthy controls methods gad patients females medically healthy volunteers assessed using childhood trauma questionnaire ctq specifically emotional abuse category proton magnetic resonance spectroscopy imaging examined regions interest roi rostral slice duyn multivoxel imaging modality rostral prefrontal cortex premotor cortex secondary somatosensory associated parietal cortex meta bolites included acetyl aspartate creatine choline results gad patients reported higher emotional abuse scores versus controls omnibus general linear model including roi metabolites laterality dependent variables revealed significant diagnosis ctq emotional abuse score interactive effect controls roi metabolites sides demonstrated significant inverse relationship emotional abuse scores none significant gad patients limitations major limitation uneven distribution emotional abuse scores controls gad patients gad patients reporting higher scores conclusion unlike controls gad patients appear compromised forming molecular representation reflective magnitude childhood emotional abuse neurometabolites gad patients appear non aligned childhood emotional abuse suggesting potential consequences normative theory mind processes emotional function certain anxiety disorders elsevier rights reserved
provide experimental basis clinic treatment observing effects simple acute hematoma cartilage synovium improvement hyaluronic acid damage twenty four new zealand white rabbits randomly divided groups according killed time hematoma group group control group rabbits killed days weeks respectively knee articular cartilage synovium obtained detect histology histochemistry chondroitin proteoglycans morphologies cartilage synovium control group normal cartilage cells detected hyperplasia activation layer disorganized hematoma groups days weeks compared control group concentrations days weeks groups significantly reduced significant difference detected weeks group control group morphology recovered normal weeks compared hematoma group morphology histochemistry improved group time frame simple acute hematoma lead temporary change morphology biochemistry application reduce damage hemarthrosis cartilaginous shorten cartilage recovery time
lipid transporter atp binding cassette class abca highly conserved multi membrane spanning protein plays critical role regulation pulmonary surfactant homeostasis mutations abca increasingly recognized one causes inherited pulmonary diseases monogenic disorders produce familial lung abnormalities pathological presentations ranging neonatal surfactant deficiency induced respiratory failure childhood adult diffuse parenchymal lung diseases specific treatment modalities remain limited abca mutations reported date approximately three quarters patients presenting compound heterozygotes recent advances understanding molecular basis underlying normal abca biosynthesis processing mechanisms alveolar epithelial cell dysregulation caused expression mutant forms beginning emerge insights role environmental factors modifier genes discussed context considerable variability disease presentation observed patients identical abca gene mutations moreover opportunities afforded enhanced understanding abca biology targeted therapeutic strategies addressed
children radiography performed diagnose vertebral fractures dual energy ray absorptiometry dxa assess bone density adults dxa assesses aimed establish whether dxa replace spine radiographs assessment paediatric vertebral fractures prospectively lateral spine radiographs lateral spine dxa children performed day independently scored three radiologists using simplified algorithm based qualitative technique blinded results modality consensus radiograph read second read random images performed diagnostic accuracy inter intraobserver intermodality agreements patient carer experience radiation dose assessed average sensitivity specificity confidence interval diagnosing one vertebral fractures requiring treatment respectively dxa radiographs fleiss kappa interobserver average kappa intraobserver reliability respectively dxa radiographs average effective dose dxa radiographs image quality similar given comparable image quality non inferior diagnostic accuracy lateral spine dxa replace conventional radiographs assessment vertebral fractures children aeuro cent vertebral fracture diagnostic accuracy lateral spine dxa non inferior radiographs aeuro cent rate unreadable vertebrae dxa lower radiographs aeuro cent effective dose dxa significantly lower radiographs aeuro cent children prefer dxa radiographs aeuro cent given dxa replace radiographs paediatric vertebral fracture assessment
three dimensional computer graphics technology widely used various areas causes profound changes information carrier models becoming increasingly important use models greatly helps improve cartographic expression design models visually efficient quicker easier understand express detailed geographical information however hard efficiently precisely fuse models local systems purpose study propose automatic precise approach fuse models geographic information systems gis basic premise subsequent uses models local systems attribute searching spatial analysis basic steps research pose adjustment principal component analysis pca silhouette extraction simple mesh silhouette extraction silhouette merger size adjustment position matching finally implement methods system automotive intelligent chart aic electronic chart display information systems ecdis fusion approach propose common method calculation step carefully designed approach solves problem cross platform model fusion models source may stored local cache retrieved internet may manually created different tools automatically generated different programs system kind gis system crown copyright published elsevier ltd rights reserved
alpha virus oncolytic virus targets zinc finger antiviral protein zap defective cancer cells may useful treatment hepatocellular carcinoma hcc hcc patients hepatitis need long term antiviral medication thus necessary clarify whether anti virus medicines influence oncolytic effect examined effect drugs used treat hepatitis mediated oncolysis vitro vivo interferon ifn alpha induces expression antiviral ifn stimulated genes isgs hcc cells moderate sensitivity virus leads reduced replication blocking mediated apoptosis antagonistic effect ifn alpha positively related expressive level isgs also examined population hcc patients total patients low zap expression liver tissues relative adjacent tissues among patients positive hepatitis positive hepatitis combination virus ifn avoided patients hbv hcv infection zap expression low isgs expression moderate conclusion study provides basis anti viral regimens hcc patients hepatitis given oncolytic virus
gnss based navigation technology lunar mission earth still lack relevant research simulation paper chang one lunar mission used three stages orbiting earth earth moon transfer around moon detailed analysis feasibility autonomous navigation using gps galileo navigation system alone combination sidelobe signals given number visible satellites gnss receiver receive dop value receiving signal level dynamic etc analyzed autonomous navigation algorithm design different observation conditions also considered seen theoretical analysis simulation results use gnss signals fully meet user needs realize autonomous navigation around earth earth moon transfer around moon three stages considered foundation future engineering applications
early embryonic stages pluripotency modeled epigenomic studies primarily human embryonic stem cells esc induced pluripotent stem cells ipscs analysis dna methylation however escs ipscs accurately reflect dna methylation levels found preimplantation embryos whole genome bisulfite sequencing wgbs approaches revealed presence large partially methylated domains pmds covering genome oocytes preimplantation embryos placenta contrast escs ipscs show abnormally high levels dna methylation compared inner cell mass icm placenta show dental pulp stem cells dpscs derived baby teeth cultured serum containing media pmds mimic icm placental methylome closely ipscs escs principal component analysis dpsc methylation patterns similar two neural stem cell types human derivation epi ncsc luhmes placenta ipscs escs human cell lines syy lymphoblast imr test suitability dpscs modeling epigenetic differences associated disease compared methylation patterns dpscs derived children chromosome maternal duplication dupq controls differential methylation region dmr analyses revealed expected dupq hypermethylation imprinting control region well hypomethylation snord novel dmrs genes including several autism candidate genes together data suggest dpscs useful model epigenomic functional studies human neurodevelopmental disorders
imaginative resistance refers perceived inability unwillingness enter fictional worlds portray deviant moralities gendler easily imagine dragons exist many people feel incapable imagining fictional worlds morality works differently although phenomenon received much attention philosophers one attempted operationalize construct self report scale study developed imaginative resistance scale irs investigated relationship theoretically related constructs confirmed structure reliability alpha large sample study asked participants rate scenarios expected provoke imaginative resistance predicted ratings irs validity measures irs scores accounted variability ease imagining scenarios gender political orientation three related measures results discussed terms theories imaginative resistance directions future research elsevier ltd rights reserved
background early stage cerebellar hemorrhage present nausea vomiting absent neurological symptoms signs potentially leading incorrect diagnosis gastroenteritis sought determine frequency gastroenteritis like presentations delayed missed diagnoses among patients spontaneous cerebellar hemorrhage methods retrospective case control analysis atraumatic primary cerebellar hemorrhages derived systematic search surgical pathology autopsy databases two large urban academic medical centers hospital visit clinical symptom data abstracted electronic paper medical records included patients delayed missed diagnoses defined least one previous visit relevant clinical symptoms days prior correct diagnosis confirmed results among records captured search filter identified cases pathologically proven primary cerebellar hemorrhage four patients misdiagnosed initially three gastroenteritis one hypertension small sample misdiagnosed patients presented often normal mental state nausea vomiting although patients deteriorated clinically initial misdiagnosis potentially dangerous diagnostic tests treatment strategies instituted result misdiagnosis none misdiagnosed patients died suffered major permanent harms due diagnostic delay conclusions study limited small number identified cases nevertheless appears patients cerebellar hemorrhages present relatively unimpressive clinical findings without obvious neurological manifestations individuals sometimes misdiagnosed gastroenteritis benign disorders initially possibly neurologic examination particularly gait testing omitted abridged careful search subtle cerebellar signs including dysarthria limb ataxia nystagmus tandem gait instability absent true gastroenteritis cases could potentially reduce misdiagnosis
thermal hydrodynamic concepts vital importance therefore assessments unavoidable purpose hydraulic systems present study implements practical updated knowledge expertise hydraulic thermal fields expert system model implemented order improve performance hydraulic system considering thermal effect hydraulic system operation accordingly computer program hydraulic system calculations designated hsc implements visual basic language microsoft visual studio software built regardless design requirements code capable deal possible connection types actuators series parallel arrangements suggested code provides designer number choices different kind connections resolve problem hydraulic oil overheating may arise continuous operation hydraulic unit result hsc able minimize human errors effort time cost hydraulic machine design
properties changes emulsion mayonnaise affected replacement long chain fatty acid oil medium chain fatty acid oil studied different ratios coconut oil cno rice bran oil rbo blended oil base study highest replacement rbo cno emulsion could achieved minimal change sensory properties emulsion stability index oil phase crystallisation temperatures mayonnaise rbo alone cno replacement change stored degrees weeks droplet size mayonnaise containing rbo increased possibly due droplet coalescence contrast droplet size mayonnaise cno rbo change storage
planet gradually moving towards urbanized world modern urban agglomerations tend turn nowadays advanced information hubs supporting smart management dynamic urban systems currently popular notion smart cities aims provide new perspective sustainable high performance strategies city stakeholders urban century context digital information technology provides new tool efficient effective management planning urban space inter alia field transportation environment public facilities advanced service provision citizens paper aims offer first concise overview emerging opportunities information communication technology ict smart urban policy digital technology particular appears provide novel pathways modern planning strategies smart cities background paper sketches complex force field global urbanisation phenomena highlights data information needs strategic planning cities using inter alia framework called urban piazza strategy framework secondly various new decision support tools currently emerging offer new promising scope handling complex urban management issues instance accessibility congestion safety sustainability briefly presented finally potential digital data systems urban management policy concisely illustrated means recent applications area smartphone data systems paper concludes discussion challenges ahead urban policy inter alia paying attention institutional governance aspects big digital data management urban systems elsevier ltd rights reserved
may june studied denning ecology barren ground grizzly bears ursus arctos equipped satellite radio collars within study area centered northeast yellowknife northwest territories canada dens located well drained slopes bar degrees choice den aspect nonrandom chi shrubs betula glandulosa salix root structures supported ceilings dens selection denning habitat bears significantly different random bonferroni confidence intervals indicated esker habitat selected expected chance den entrance occurred primarily last weeks october majority bears emerged dens week may
objective today esophageal cancer become one common cancer types china therefore new drug therapeutic strategies urgently needed improve postoperative survival rate patients food additive several lines evidence shown citric acid served glycolysis suppressor inhibit growth tumor cells however little known effect organic acid growth human esophageal carcinoma cell line materials methods experimental study cell proliferation rate determined using mtt assay apoptotic morphological changes evaluated fluorescent microscopy using hoechst staining cell apoptosis rate mitochondrial membrane potential mmp detected using flow cytometry effect citric acid cellular membrane permeability assessed measuring lactate dehydrogenase ldh activity using ldh assay kit results compared control group marked decrease cells proliferation cells treated higher citric acid concentrations typical apoptotic morphology cells observed upon treatment citric acid chromatin condensation appearance apoptotic body cell apoptotic indexes significantly increased treatment citric acid concentration extracellular ldh activity loss mmp treated groups significantly higher control dose dependent manner conclusion results suggest citric acid prevents cell growth inhibiting cell proliferation inducing apoptosis perhaps offers theoretical guidance application treatment
work studies morphological changes taking place goat omasum prenatal development using scanning electron microscope light microscopy immunohistochemical analysis total goat embryos fetuses used first stages prenatal life birth differentiation omasum separate compartment primitive gastric tube observed days prenatal life crown rump length crl gestation days crl gestation omasal wall comprised three layers internal epithelial layer middle layer pluripotential blastemic tissue external layer serosa omasal laminae appeared following order primary days crl gestation secondary days crl gestation tertiary days crl gestation quaternary days crl gestation neuroendocrine cells detected synaptophysin syp days crl gestation glial cell markers glial fibrillary acidic protein gfap vimentin vim observed days crl gestation days crl gestation respectively sympathetic parasympathetic nerve fibers nerve bodies detected via neuropeptide npy vasoactive intestinal polypeptide vip days crl gestation conclusion prenatal development omasum like rumen appears take place somewhat earlier goats sheep cattle similar stage reported deer
aim paper present development proposal use model mechanical electrical simulating system heart teaching tool teaching learning electrical circuits grade eleven secondary education methodology following phases developed design didactic model planned activity class work based constructivist methods knowledge previous ideas testing laboratories mechanical movement heart confrontation ideas experimental process adaptation educational model circuit application teaching model electric circuits classroom teaching academic practice conducted students educational institution city florencia caqueta dominic savio results application teaching tool allows better understanding physical concepts electrical circuits especially circuits strengthening theoretical elements student use models similar issues studied concluded study actual situations everyday life complemented realization experimental practices contributes greatly understanding scientific issues
internships becoming overall part engineering curricula cooperative learning initiative attractive bridge students enter labor market stakeholders role analyzed interactions outlined order raise main drivers preference factors every participant process disparity assessment internship source disaffection reducing priori attractiveness stage potential contribution students learning based different scales values aims analytic hierarchy process ahp partially used put rationale frequently contradictory objectives stakeholders new concept alignment helps simulated case study illustrates use methodology potential applications internship management process proposed authors published elsevier ltd
depression linked long term risk variety physical health ailments including coronary heart disease chd little known resilience factors may attenuate relationship current study assessed whether social support moderates long term risk chd associated disorder data drawn americans changing lives study nationally representative longitudinal survey adults united states participants unweighted completed initial assessments functional social support body mass index recent history major depression chd hypertension diabetes participants assessed chd follow assessment years later social support found moderate relationship depression occurrence chd years later specifically among individuals low social support depression prospectively associated chd contrast depression prospectively associated chd among individuals high social support results indicate social support may function resilience factor long term cardiovascular risk associated depression clinical interventions focusing development social support systems important addressing depression also associated long term physical health outcomes
pumice breccia natural material available vast deposit volume indonesia especially yogyakarta area main characteristics type rock lightweight low thermal conductivity pumice breccia utilization expected support implementation green building concept minimizing electrical power needs may required setting room temperature air conditioning system aim study evaluate effect pumice breccia utilization fine aggregate various compositions thermal conductivity compressive strength mortar study conducted using experimental method determine thermal conductivity compressive strength variation mortar two types mortar investigated research first type normal mortar using sand fine aggregate mixture compositions variations portland cement sand labeled second type mortar pumice breccia mortar utilizing pumice breccia material fine aggregate mixture compositions variations portland cement pumice breccia named composition mortar mixtures prepared based volume ratio test results show using pumice breccia fine aggregate mortar mixtures thermal conductivity normal mortar reduced nearly considerably even though reduction compressive strength observed compositions mortar mixtures based sni still pumice breccia based mortar classified type mortar used partition walls protective decorative purposes authors published elsevier ltd
automatic fast efficient estimation physical characteristics mass volume agricultural products improves postharvest processes sorting storage document presents computer vision system automatically estimate characteristics passion fruit visible aspects digital images color texture size shape correlated actual measurement defining model estimating mass volume pca principal component analysis lda linear discriminant analysis used like statistical data analysis ann artificial neural network estimation tool methods applied sample set consisting images passion fruit used training validation results greater terms correlation coefficient typical error less compared sample standard deviation two variables
past decade researchers humanities design science engineering collectively working towards realization ambient intelligence vision thematic issue records evolution field fosters scientific debate research issues reflection progress ambient intelligence future
colorectal cancer incidence paralleled increases human development across countries yet marked decreases incidence observed countries attained high human development thus study explored relationship human development colorectal cancer incidence particular assessed whether national transitions high human development linked temporal patterns colorectal cancer incidence analyses utilized human development index hdi annual incidence data regional national cancer registries truncated years age standardized incidence rates calculated yearly incidence rate ratios hdi ratios transitioning high human development also estimated among countries investigated colorectal cancer incidence observed decrease reaching high human development threshold countries decreases also observed five countries age standardized incidence rates remained higher observed threshold declines stabilizations likely due colorectal cancer screening populations well varying levels exposure protective factors summary appears threshold human development predicts stabilization decline colorectal cancer incidence though pattern observed countries assessed future cancer planning must consider increasing colorectal cancer burden expected countries transitioning towards higher levels human development well possible declines incidence among countries reaching highest development level new lifestyles associated westernization increasingly predominant countries social mobility economic growth rise incidence colorectal cancer crc likewise risen countries though areas high human development experiencing alternate trends crc incidence found decreased countries attained high levels human development though evident countries analyzed data suggest existence threshold crc incidence stabilizes declines according human development index
chinook salmon oncorhynchus tshawytscha external fertilizers display sneak guard alternative reproductive tactics larger hooknose males dominate mating positions smaller jack males utilize sneak tactics achieve fertilization although poorly understood previous studies suggested differences spermatozoa quality may play critical role sperm competition considering seminal plasma strongly regulates spermatozoa quality processes critical fertilization success employed label free quantitative mass spectrometry utilizing ion mobility separation coupled cross species bioinformatics examine seminal plasma proteome chinook salmon total proteins identified biological replicates analyzed including many established seminal plasma proteins may serve future biomarkers chinook salmon fertility sperm competition moreover elucidated statistically significant protein abundance differences hooknose jack male tactics proteins involved membrane remodeling proteolysis hormonal transport redox regulation immunomodulation atp metabolism among proteins reproducibly identified different levels represent putative factors influencing sperm competition jack hooknose males study represents largest seminal plasma proteome teleost fish first reported chinook salmon significance chinook salmon oncorhynchus tshawytscha males represent example male alternative reproductive tactics diverse reproductive strategies thought increase sexual selection seminal plasma shown play important regulatory role sperm competition many species little known protein composition seminal plasma salmon therefore seminal plasma isolated two alternative reproductive tactics chinook salmon small sneaky jacks large dominant hooknoses analyzed label free quantitative mass spectrometry employing data independent acquisition ion mobility separation yielded largest proteome data set seminal plasma salmon first examine protein abundance differences male alternative reproductive tactics quantitative proteomic data provides insight possible unique mechanistic aspects chinook salmon alternative reproductive tactics utilized sperm competition fertilization success elsevier rights reserved
sports injury refers injuries process sports many reasons injuries divided direct causes incentives direct causes include lack attention ideologically lack reasonable warming technical errors heavy sports load bad physical functions mental states improper methods organizations rough sports violation rules defects venues equipment influence bad weather incentives include two aspects technical features various sports physiological characteristics local anatomy therefore pay attention prevention sports injuries paper author carries analyses researches discussion causes prevention sports injuries important significance improvement sports training organization kinds sports competitions
individuals ultra high risk uhr psychosis transition frank illness nevertheless many poor clinical outcomes impaired psychosocial functioning study used voxel based morphometry investigate baseline grey white matter brain densities identification uhr associated functional outcome medium long term follow participants help seeking uhr individuals underwent magnetic resonance imaging baseline functional outcome assessed average years later primary analysis showed lower baseline grey matter density white matter density bilateral frontal limbic areas left cerebellar declive associated poorer functional outcome social occupational functioning assessment scale sofas findings independent transition psychosis persistence risk mental state similar regions significantly associated lower self reported levels social functioning increased negative symptoms follow exploratory analyses showed lower baseline grey matter densities middle inferior frontal gyri significantly associated decline global assessment functioning gaf score follow association baseline grey matter density positive symptoms followup current findings provide novel evidence poorest functional outcomes lowest grey matter densities identification uhr regardless transition status persistence risk mental state replication validation findings may allow early identification poor functional outcome targeted interventions
introduction reactive arthritis rea undifferentiated spondyloarthritis uspa belong group autoinflammatory diseases called spondyloarthritis spa hypotheses proposed relationship intestinal mucosa inflammation joint tissues role immunoglobulin iga secretory immunoglobulin siga inflammatory clinical activity patients spa remains poorly understood objective evaluate status total iga siga association among levels siga iga iga anti chlamydia trachornatis anti shigella spp disease activity measures erythrocyte sedimentation rate esr reactive protein crp levels compared cohort patients rea uspa healthy subjects methods cross sectional study serum concentrations siga iga anti trachornatis anti shigella spp total iga measured disease activity measured patient means bath ankylosing spondylitis disease activity index basdai ankylosing spondylitis disease activity score asdas statistical analysis include bivariate evaluation comparisons student test kruskalwallis test mann whitney test multivariate evaluation principal components analysis pca correlation analysis carried using pearson correlation coefficient linear regression models analysis made using stata version windows statistical significance defined value results patients men mean age years controls men mean age years included study mean serum levels siga higher spa patients healthy subjects siga levels correlated disease activity basdai asdas crp asdas esr negative correlation siga activity indices higher hla positive patients basdai asdas crp asdas esr pca showed three factors first component constituted variables referred clinical activity measures second include serological activity markers last component compounded age symptoms time conclusion elevated serum levels siga found related low disease activity patients rea uspa
electro optical transceivers implemented employing analog signal processing order achieve low values power consumption latency paper shows spectral efficiency solutions increased combining orthogonal multicarrier techniques shelf microwave components real time gbit experiment performed emulating wavelength division multiplexing wdm system composed five optical channels optical carriers provided externally injected gain switched optical frequency comb optical channel transmitted gbit orthogonal subcarrier multiplexing scm signal modulated demodulated electrical domain without requirement digital signal processing net data rate remained higher gbit taking account forward error correction overheads use orthogonally overlapping subchannels achieves unprecedented spectral efficiency analog real time broadband wdm scm links
currently use large ontologies various areas knowledge increasing since ontologies present overlapping content identification correspondences entities becomes necessary different tasks example data integration data linkage matching large ontologies challenge since involves excessive number comparisons entities leads high execution times requires considerable amount computing resources work proposes fine grained load balancing technique applied partition parallel based ontology matching ppom approaches ppom approach partitions input ontologies sub ontologies executes comparisons entities parallel instance using mapreduce sense fine grained load balancing technique aims guide even distribution comparisons among nodes cluster infrastructure experimental results indicate proposed load balancing technique able reduce overall execution time ppom approaches elsevier rights reserved
learning program computer code considered one pillars contemporary education benefits reach well beyond skills required computing industry creativity self expression nevertheless execution computer programs usually takes place traditional desktop computer limited repertoire input output interfaces engage user hand pedagogy emphasized physical representations tangible interactive objects benefit learning especially young students work explore benefits learning code ubiquitous computers robots wearable computers comparison programming desktop computer purpose thirty six students participated within groups study involved three types tangibility target computer platform desktop scratch wearable arduino lilypad robotic lego mindstorms regardless target platform employed desktop visual programming environment mit scratch modkit enchanting measured emotional engagement assessed students programming skills found students expressed positive emotions programming robotic rather desktop computer furthermore tangible computing platforms affect dramatically students performance computational thinking
dominant discourses immigrant value taiwan across asia distinguish marital immigrants desirable professional immigrants assumed contribute talents economic productivity new home article examines national anxieties compromised value marital immigrants illustrates strategies adopted immigrant spouses carve new means producing value productive reproductive labors focusing mainland chinese spouses taiwan article argues contested political relations taiwan china foster immigration policies construct chinese marital immigrants familial dependents whose material desires suspect political commitments held check identification reproductive care labors article asks complex devaluation system affects life strategies comparatively elite marital immigrants chinese women men postsecondary degrees former professional careers china article analyzes immigrants maneuver around policies restrict access skilled employment yet without necessarily rejecting reproductive contributions taiwanese society elite spouses experience new forms precariousness produced intersection intimate life decisions heteronormative gender roles aspirations self fulfillment insecurities immigrant status
automotive application strong need compact multifunctional microwave antennas example cellular phones gps usa satellite radio mutual coupling antennas leads alterations antenna pattern particular antenna sdars satellite system accepted providers paper shown impact two phone antennas sdars antenna reduced negligible amount
background rate premarital sexual activity unwanted pregnancies illegal abortions remain higher among university students calls understanding knowledge contraceptive use sexual behaviours among high risk group incidence unintended pregnancy illegal abortions high sexual risky behaviour minimized study aimed assess ssexual behaviour contraceptive knowledge use among female undergraduates students muhimbili dar salaam universities tanzania methods cross sectional analytic study conducted among undergraduate female students two universities located dar salaam region tanzania study period june october self administered questionnaire given students retrieved giving response rate data analyzed using statistical package social science spss windows version descriptive statistics summarized chi square test used examine relationship various sociodemographic sexual behaviours variables contraceptive use value less considered statistically significant results results showed majority students sexual intercourse participants knowledge contraception half sexually active women reported ever used contraception current contraceptive users majority sexually active group started sexual activity young age years condom pills known contraceptive methods popular method contraception used condoms withdrawal periodic abstinence main sources information contraception friends radio school respectively forty women pregnancies unwanted pregnancies among induced abortion marital status age first sex ever sex ever pregnant unwanted pregnancies associated use contraception conclusions student knowledge contraception however rate contraception use still low majority respondent sexually active majority started sexual activity young age needs advocacy adolescence reproductive health education promote use available contraceptive services amongst university students
aims objectives assess acceptability usability standardised communication tool nurses background significance communication key health care daily hourly basis nursing staff inundated new information regarding tools resources practice changes work environment however currently standardised messaging delivery method effectively communicate new information even plethora communication tools flyers posters emails unit huddles unit meetings means guarantee attendance crucial information design descriptive cross sectional online survey implemented nonacademic suburban hospital nurses methods clinical chatter online tool developed nursing leadership standardise messages regarding organisation new tools resources professional development recognition unit updates delivered nurse weekly basis followed administration acceptability usability scales results clinical chatter tool adequate acceptability usability method communication among nurses hospital organisation sociodemographic variables age years experience statistically significant association perceived acceptance usefulness tool conclusion findings indicate clinical chatter tool used standardised communication tool deliver key information among nurses working hospital organisation nursing leadership must establish support clear communication system enhance patient care outcomes improve nursing job satisfaction relevance clinical practice communication vital advancing health care lack communication among nursing linked unsafe patient care medication errors unhealthy work environments decreased nurse retention rates clinical chatter effective communication tool presentation institutional information nursing personnel
kinds internet security incidents serious malicious code increasingly serious problem caused malicious code make enterprises users suffered huge economic losses also makes network security facing serious threat paper based analysis malicious code detection technology detection system author designs implements unknown malicious code detection system based network behavior analysis test results show detection system distinguish three kinds arp attack produce normal alarm information achieve desired results time network behavior analysis method needs improved order achieve better analysis results provide reliable results detection system
number neonatal intensive care units nicus designed meet basic criteria green design increasing organizations however reluctant embark program sustainability resistance typically due cost concerns lack knowledge accomplish goals sustainability paper evaluates availability quality information regard sustainable nicu design sources information provided including leed leadership energy environmental design system authored green building council recommended standards newborn icu design among topics explored via literature review green nicus sustainable materials equipment energy water conservation recycling waste disposal nature access daylight also identified contributors sustainability role biophilia innate affiliation humans nature nicu settings also discussed elsevier inc rights reserved
background short form international physical activity questionnaire ipaq validated questionnaire used assess physical activity healthy adults commonly used apparently healthy adults cancer patients however ipaq previously validated cancer patients undergoing oncologic treatment objective present study compare ipaq objective measures physical activity cancer patients undergoing chemotherapy methods present study part month prospective individualized lifestyle intervention focusing diet stress management smoking cessation cancer patients undergoing chemotherapy first two months lifestyle intervention participants wearing activity monitor sensewear armband swa five consecutive days receiving chemotherapy completing ipaq swa moderate vigorous intensity mvpa bouts min compared self reported mvpa ipaq analyses included excluded walking mvpa ipaq results extrapolated wearing time seven days results sixty six patients completed ipaq wore swa five days mean difference limit agreement ipaq swa including walking min analyzing time spent different intensity levels separately ipaq reported significantly higher levels moderate min vigorous min compared swa conclusions cancer patients participating lifestyle intervention chemotherapy reported higher mvpa level past seven days using ipaq compared objective measures ipaq appears insufficient assessing level cancer patients undergoing oncologic treatment activity monitors objective tools alternatively considered assessing population
although past research documented effects diverse types media content male body image effects violent media content remain unexamined experimental study college age men exposed either violent nonviolent narratives accompanied either muscular ideal nonmuscular images men exposure violent narratives predicted lower self perceived physical attractiveness greater body anxiety greater endorsement body modification methods though last effect moderated self monitoring exposure muscular ideal images also predicted increased body anxiety body modification endorsement violence muscularity interaction effects observed mediation analyses indicated effect violent narratives body image mediated activation stereotypical masculinity suggesting either direct cognitive links violence appearance yet unidentified process
large flexible engineering structures long span bridges tall buildings susceptible quasi static dynamic deformations caused different loadings thus accurate displacement measurements desirable assess integrity reliability structure study integrated system includes global positioning system gps accelerometer anemometer developed obtain responses long span bridge extreme wind loadings spectral analysis based fast fourier transform fft algorithm first carried detect dominant frequencies middle pylon noisy gps displacement measurements accelerometer data noised using vondrak filter low frequency disturbance separated gps displacement time series least squares based displacement reconstruction scheme using noise mitigated accelerations employed tikhonov regularization scheme optimal selected regularization factor used alleviate ill posedness last adaptive recursive least squares rls filter adopted separate slow varying movements total displacement enhanced measurement accuracy obtained combined quasi static high frequency dynamic displacements field monitoring data set collected erqi yangtze river bridge three tower cable stayed bridge located wuhan china used validate effectiveness proposed integration processing scheme gps accelerometer anemometer installed center supporting tower used characterize interaction responses ambient wind loadings results demonstrate proposed technique significantly improve measurement accuracy pylon displacement strong winds deformation accuracy amplitude several millimeters successfully detected spectrum pylon response obtained gps data accelerometer data reveals identified first dominant frequency middle pylon elsevier ltd rights reserved
despite improved survival due combination antiretroviral therapy cart youth perinatallyacquired hiv phiv show cognitive deficits developmental delay increased rates hiv affects brain critical periods development brain may persistent reservoir hiv due suboptimal blood brain barrier penetration cart conducted structural magnetic resonance imaging smri cognitive testing phiv youth mean age years recruited nih pediatric hiv aids cohort study phacs part first generation phiv youth surviving adulthood historical current hiv disease severity substance use measures also collected total regional cortical grey matter brain volumes compared group typically developing hiv unexposed uninfected youth frequency matched age sex pediatric imaging neurocognition genetics ping study mean age years phiv youth smaller total regional grey matter volumes hiv unexposed uninfected youth smallest volumes seen among phiv youth higher past peak viral load recent unsuppressed phiv youth worse cognitive performance correlated smaller volumes pattern smaller grey matter volumes suggests phiv infection may influence brain development underlie cognitive dysfunction seen population among phiv youth smaller volumes also linked substance use alcohol use marijuana use study collection substance use information limited phiv cohort future studies also collect substance use information controls address interactions hiv substance use brain volume elsevier inc rights reserved
purpose purposes study describe baseline data implementation evidence based clinical practices among health center partners part community wide teen pregnancy prevention initiative identify opportunities health center improvement methods health center partner baseline data collected first year program implementation year community wide teen pregnancy prevention initiative needs assessment health center capacity implementation evidence based clinical practices administered health centers partners communities united states high rates teen pregnancy results health centers reported inconsistent implementation evidence based clinical practices providing reproductive health services adolescents approximately offered day appointments infrastructure reduce cost barriers offered school appointments prescribed hormonal contraception without prerequisite examinations testing approximately three quarters provided visual audio privacy examination rooms counseling areas fewer offered wide range contraceptive methods took sexual health history every visit reported quick start initiation hormonal contraception emergency contraception intrauterine devices always available adolescents conclusions assessment highlighted opportunities health center improvement strategies build capacity health center partners implement evidence based clinical practices may lead accessibility quality reproductive health services adolescents funded communities published elsevier inc behalf society adolescent health medicine
new research field translational neuroscience opened result recognition since spreading depression tilde detected many patients acute brain injury whether vascular spontaneous traumatic origin well many individuals experiencing visual sensorimotor aura migraine review trace first description rabbits detection study migraine injured human brain personal perspectives evolution understanding importance spread mass depolarisations cerebral grey matter detection spontaneous depolarisations occurring spreading periphery penumbra experimental focal cortical ischemic lesions adverse effects cerebral cortical microcirculation tissue glucose oxygen pools led clearer concepts ischaemic traumatic lesions evolve injured human brain seek improve clinical management outcome recognition likely fundamental significance spreading depolarisations wide range serious acute encephalopathies humans provides powerful case fresh examination neuroprotection strategies
purpose risk problematic internet use arpiu associated impairment multiple domains including psychopathology present study examined relationship arpiu disordered eating large community sample methods participants completed online survey health behaviors two thresholds arpiu disordered eating examined results arpiu sub subthreshold eating disorders groups reported greater depressive symptoms poorer self control control group sub group reported greater impulsivity control group arpiu sub groups significantly differed key features related condition finally occurrence arpiu sub associated greater depression second set analyses based stringent thresholds problematic internet use piu groups differed measures compared control group piu groups also differed key features related condition differ measures impulsivity self control occurrence piu associated greater depressive symptoms either piu independently conclusions arpiu sub share links depression poor self control may represent possible therapeutic targets across internet use disordered eating behaviors occurring piu either lenient stringent thresholds associated greater depression future studies examine temporal nature associations extent targeting depression internet use disordered eating may lead improvements across domains elsevier ltd rights reserved
study compares degree creativity forty two conceptual designs proposed solutions two innovative design problems developed face face virtual collaborative environments solutions obtained evaluated three experts applying moss metric considers level usefulness level unusualness average values trends data obtained analysis variance also performed determine whether environment influences degree creativity results show proved level creativity influenced working face face virtually whether information communication technologies used effect final result
healthcare associated infections hcai represent major risk patient safety infections preventable international save lives clean hands campaign announced annually may hand hygiene particularly hand disinfection dependent time execution disinfection procedure well efficacy substance used alcohols represent valid safe substances however adequate skin care must also addressed appropriate actions include preparing skin hand protection plan necessary performing occupational health check
image set representation classification important problem computer vision pattern recognition area widely used many computer vision applications paper new image set representation classification method proposed main contributions paper twofold new image set representation model called attributed covariate relation graph acrg proposed image set representation modeling acrg aims represent image set attributed graph model involves image features spatial structure simultaneously new graph data based sparse representation classification method called graph sparse representation classification gsrc proposed achieve acrg classification experimental results several datasets demonstrate benefits proposed acrg representation gsrc classification
paper present system capture animate highly realistic avatar model user real time animated human model consists rigged mesh texture map system based kinectv input captures skeleton current pose subject order animate human shape model additional high resolution rgb camera used capture face updating texture map frame combination image based rendering computer graphics achieve photo realistic animations real time additionally approach well suited networked scenarios low per frame amount data animate model consists motion capture parameters video frame experimental results demonstrate high degree realism presented approach
background cyclooxygenase cox expressed female reproductive organs therefore inhibitors cox may affect reproductive function evaluated effect extended administration meloxicam ovulation menstrual cycle hypothesis meloxicam administered menstrual cycle day could interfere follicular rupture without disrupting menstrual cycle could potential non hormonal contraceptive method methods study conducted healthy sterilized women onset treatment end treatment participants observed control cycle ensure progesterone serum levels nmol consistent ovulation participants treated days three consecutive cycles randomized day menstrual cycle monitored serial ultrasound hormone assays blood results fifty six volunteers completed study cycles treated day cycles treated day observed dysfunctional ovulation defined follicular rupture preceded earlier peak preceded blunted peak nmol ovulation observed women lower dose group higher dose group respectively differences two doses parameters measured serious adverse events adverse events different doses control treated cycles conclusions although administration meloxicam menstrual cycle days resulted dose dependent inhibition ovulation subjects normal ovulation highest dose elsevier inc rights reserved
paper discusses magnetic drag force resulting relative motion permanent magnet moving along finite dimensional conducting plate image method imaginary eddy currents investigated boundary conditions established ensure eddy currents vanished boundaries conducting plate magnetic drag force computed based eddy current distributions using lorentz force law test system built demonstrate magnetic brakes arose electromagnetic interactions
grey wolf optimization algorithm proposed design proportional integrative derivative controllers using two degrees freedom control configuration control system designed order achieve good set point tracking disturbance rejection performance design accomplished minimizing aggregated cost function based time weighted absolute error integral subjected robustness constraints control system robustness levels prescribed terms vector margin maximum complementary sensitivity function values simulation results presented several common systems dynamics compared ones obtained particle swarm optimization algorithm
research treatment nervous system challenged many physiological barriers posing major hurdle neurologists cns protected formidable blood brain barrier bbb limits surgical therapeutic diagnostic interventions hostile environment created reactive astrocytes cns along limited regeneration capacity pns makes functional recovery tissue damage difficult inefficient nanomaterials unique ability interface neural tissue nano scale capable influencing function single neuron ability nanoparticles transcend bbb surface modifications exploited various neuro imaging techniques targeted drug delivery tunable topography nanofibers provides accurate spatio temporal guidance regenerating axons review attempt comprehend progress understanding obstacles posed complex physiology nervous system innovations design fabrication advanced nanomaterials drawing inspiration natural phenomenon also discuss development nanomaterials use neuro diagnostics neurotherapy fabrication advanced nano devices use opto electronic ultrasensitive electrophysiological applications energy efficient parallel computing ability human brain inspired design advanced nanotechnology based computational systems however extensive use nanomaterials neuroscience also raises serious toxicity issues well ethical concerns regarding nano implants brain conclusion summarize challenges provide insight huge potential nanotechnology platforms neuroscience elsevier ltd rights reserved
data available long term outcomes increased physical activity end inpatient treatment patients anorexia nervosa hence assessed association physical activity measured objectively sense wear armband swa body mass index bmi menses resumption one year follow females anorexia nervosa restored normal body weight end specialist inpatient treatment combined logistic regression models used evaluate relationship variables discharge bmi resumption menses one year follow revealed significant association bmi one year follow physical activity patterns inpatient discharge however total daily steps inpatient discharge significantly lower patients resumed menstruation confirmed logistic regression analysis small reduction daily steps inpatient discharge steps found increase probability menses resumption one year follow data provide preliminary indications potential usefulness assessing daily steps predict resumption menses one year follow patients anorexia nervosa restore body weight end inpatient treatment although confirmation larger samples urgently required
background school nurses provide direct services children asthma educate reinforce treatment recommendations children families coordinate school wide response students asthma emergencies unfortunately school based health services today depend unreliable patchwork funding limited state local funds lead extremely low nurse student ratios resulting missed opportunities prevention care asthma health conditions methods carried nonsystematic review legal government private health foundation medical literature results many health services asthma conditions provided school settings services typically covered medicaid children health insurance program chip offered settings however complex reimbursement rules questionable policy guidance establishing free care rule barriers limited ability schools seek medicaid chip reimbursement services recent legal developments may help overcome barriers new flexibilities medicaid law bring opportunities increased reimbursement school based health services conclusions policymakers call centers medicare medicaid services abandon free care rule issue guidance would enable schools appropriately obtain medicaid reimbursement nursing services
aberrations gene methylation stool dna sdna effective biomarker non invasive colorectal cancer diagnosis however challenging accurately quantitate gene methylation levels sdna due low abundance degradation sdna study digital quantification strategy proposed combining emulsion pcr empcr hydrogel immobilized bead array assay includes following steps bisulfite conversion sdna pre amplification pcr specific primers containing universal sequences empcr pre amplicons beaded primers achieve single molecular amplification identification hydrogel embedding beads coated amplicons sensitivity specificity method high enough pick methylated targets unmethylated dna background successful detection hypermethylated vimentin gene clinical stool samples suggests proposed method potential tool non invasive colorectal cancer screening
year old male heterotaxy left isomerism dextrocardia composed single ventricle absent inferior vena cava bilateral superior vena cava svc common atrioventricular valve received orthotopic heart transplantation htx long waiting period status reconstructions bilateral svc hepatic vein route successful without use prosthetic material donor heart placed left mediastinum spite satisfactory early recovery patient expired months transplantation mainly fungal infection developed following humoral rejection htx adult patients complex congenital heart disease demanding technical well pre post transplant management indication critically determined
research increasingly pointing importance extending focus childhood obesity intervention include fathers fathering figures members child primary parenting network advances communication technology making possible achieve aim within current resources using modalities text messaging web based resources apps extend intervention parents attendance face face interactions however published research often unclear parent targeted engaged whether interventions planned influence behaviours capabilities across family systems achieved childhood obesity research employing information technology engage family systems takes hold becoming important researchers clearly describe engage hope achieve pathways influence aim activate paper integrates extant knowledge family systems thinking parenting efficacy parenting family intervention way parents represented reported childhood obesity research paper concludes recommendations terminology used describe parents parenting figures future studies
principal component analysis widely used various fields research bioinformatics medical statistics etc especially high dimensional data analysis although crucial components selection vital matter principal components analysis relatively little attention paid issue existing studies principal component analysis based hoc methods method cumulative percent variance average eigenvalue propose novel method selecting principal component based type regularized regression modeling order effectively perform principal component regression consider adaptive type penalty based singular values components propose adaptive penalized principal component regression proposed method perform feature selection incorporating explanation power components high dimensional predictor variables also response variable sparse regression modeling choosing regularization parameter crucial issue since feature selection estimation heavily depend selected regularization parameter derive model selection criterion choosing regularization parameter proposed adaptive type regularization method line generalized information criterion monte carlo simulations real data analysis demonstrate proposed modeling strategies outperform principal component regression modeling
present exact closed form solution two coupled homogeneous well inhomogeneous first order difference equations variable coefficients solution obtained using graph theoretic discrete path formalism central parameters solution crossing index crossing number transition enumerative graph theoretic solution closed form combinatorial solution made possible isomorphism paths signal flow graph tuplets binary numbers
comprehensive bird view research note combines state art brief presentation history original solutions position like views prospective future developments one relevant interesting areas related use fuzzy logic database management systems notably querying component extent broader issue data information management briefly summarize roots new applications fuzzy logic relevant proposals development context fuzzification basic relational database model generalizations particularly focus fuzzy querying human consistent friendly way retrieving information due real human intentions preferences expressed natural language represented via fuzzy logic possibility theory mention extensions notably fuzzy queries linguistic quantifiers point close relation linguistic summaries newer prospective developments mainly focus bipolar queries accomodate users intentions preferences involving sort required desired mandatory optional etc conditions show various ways handling queries conclude brief position statements view relevant promising directions challenges elsevier rights reserved
aim study show proportion workplace accidents related materials transfer decide whether serious kinds workplace accidents research material study statistics data available finland regarding workplace accidents fatal accidents twenty five percent studied fatal accidents related materials transfer workplace accidents finland workplace accidents related materials transfer half workplace accidents related materials transfer caused disabilities lasting days accidents related materials transfer occurred men aged years common types injuries dislocations sprains strains
epstein barr virus ebv infection closely related carcinogenesis various cancers also associated development drug resistance cancer stem cells however ebv positive cancer cells mechanistic details downstream signaling connection pik kappa pathway development drug resistance remain controversial diffuse large cell lymphoma dlbcl multiple myeloma cells infected ebv display drug resistance related proteins mdr mrp mrp stem cell markers oct sox ebv infected ebv ebv cells activated delta expression downregulated expression alpha beta combination cal delta specific inhibitor bortezomib treatment ebv cells synergistically suppressed proliferation reduced levels drug resistance related proteins activated caspase cleavage recovered expression alpha beta additionally treatment cal bortezomib attenuated expression oct sox via inhibition activated kappa treatment cal bortezomib also attenuated drug resistance kappa activity ebv infected cells results provide supportive evidence clinical application cal bortezomib treat ebv infected hematologic cancer
paper deals study process allows use waste sulphates drywalls plasterboards cement chemistry without affecting resistance cement since cement industry important sulphate consumer role recycling temperature obtain recycled calcium sulphates rcs contents rcs used set retarders cements also studied gypsum drywalls plaster paris plasterboards heated three recycling temperatures degrees degrees degrees partially dehydrated obtain rcs chemical composition purity rcs natural gypsums determined compared via xrd dsc setting time compressive strengths microstructure cements rcs used set retarder studied main products formed cement hydration determined xrd microstructure observed sem edx internal porosity different blends area per diameter distribution determined image processing computer aided design cad software sem images cements rcs plasterboards set retarder higher content higher amount hemihydrates preheated degrees mechanical strengths according cement standards show denser microstructure lower porosity homogeneous matrix final setting cements rcs drywalls selection suggested waste sulphates preheating process allow using recycled sulphates debris cement industry according standards elsevier ltd rights reserved
recent research community involvement points importance agentic advancing self communal motives serving others key predictors though studies examined simultaneously time research identified generativity defined concern future generations legacy self particularly relevant community involvement moreover generativity involves agentic communal motives meaning advancing personal goals caring others integrated construct therefore purpose study examine individual differences attributes pertaining self others specifically self esteem initiative empathy related generativity community involvement sample adolescents female mage sample young adults female mage completed survey including measures community involvement generativity generative concern fully mediated associations individual differences self esteem initiative empathy community involvement suggesting early generativity role fostering capacities contribution youth developmental indicators pertaining self others link actions benefit community desire benefit future generations
study proposes adaptive neuro fuzzy inference system anfis based rotor position controller brushless direct current bldc motors improve control performance drive transient steady state conditions dynamic response bldc motor proposed anfis controller considered standard reference input effectiveness proposed controller compared proportional integral derivative pid controller fuzzy pid controller proposed controller solves problem nonlinearities uncertainties caused reference input changes bldc motors guarantees fast accurate dynamic response outstanding steady state performance furthermore anfis controller provides low torque ripples high starting torque detailed study includes matlab based simulation experimental prototype illustrate feasibility proposed topology
government sierra leone cut national budget allocation health sector civil society organizations planned nationwide health budget advocacy campaign coinciding general elections hold future leaders account financing women children health part campaign evidence action produced district health budget tracking scorecards scorecards presented ministry finance data allocation disbursement health funds district data communicated using simple non technical language citizens could understand key messages take action total scorecards shared district electoral forums attended political candidates community members health activists since election proportion total government budget allocated health increased however transforming politicians commitments pledges implementation challenging confirming accountability long term process international federation gynecology obstetrics published elsevier ireland ltd open access article license
activities project center nanotechnology advanced engineering nae manufacturing engineering reported focusing onto recent trends developments advanced manufacturing advanced materials important engineering topics industrial research academic point view nanotechnology nanostructured materials ultraprecision engineering net shape manufacturing mainly powder processing shock loading applications various fields science engineering machine tool industry biomedicines energy conservation transport namely automotive aircraft industry etc
objectivesthe department health england developed welcome framework comprising criteria health services seeing year olds improve quality coverage reduce access inequities date however welcome criteria considered within community pharmacy service development policy aim article assess relevance welcome criteria community pharmacy examine ways currently met met guide future service development methodsthe project employed three methods checklist guided observations face face semistructured interviews staff members undertaken eight community pharmacies across england scotland purposively selected known focus provision young people services complemented cross sectional online survey completion pharmacy staff across wider range pharmacies recruited targeted local pharmaceutical committees lpc study instruments designed gather information relevant welcome criteria key findingseight pharmacies took part observations interviews six lpcs posted online survey link website returned respondents results demonstrate applicability welcome criteria community pharmacy services highlighting particular strengths community pharmacy services young people accessibility well opportunities priorities service development meet specific needs staff training engagement integration local service provision conclusionsthe welcome criteria applied community pharmacy services without adaptation providing appropriate framework guide service development promote young people friendly pharmacy services
obesity affects social classes making necessary develop effective products aid weight loss help prevent weight gain objective work study anti obesity effects structured lipids obtained enzymatic interesterification based olive oil soy oil fully hydrogenated crambe oil twenty four mice distributed four experimental groups according diet consumed control diet structured lipids diet sld high fat control diet hcd high fat structured lipids diet hsld animals fed sls presented smaller weight gain despite larger intake diet lowest weight gain reflected reduced amounts adipose tissue lower liver weight significant increase lipids excreted animals feces observed despite sign toxicity presence diarrhea animals consumed hsld presented lower total ldl cholesterol increased hdl cholesterol increased hepatic arachidonic acid docosahexaenoic acid levels addition develop hepatic steatosis study therefore showed sls could play major role combating preventing obesity resultant diseases without producing side effects elsevier ltd rights reserved
present study evaluated consistency reliability determinants two real world measures adherence prescription schizophrenia non schizophrenia patients treatment resistant schizophrenia trs additionally diagnosed schizophrenia patients patients screened clinical severity cognitive functioning adherence item drug attitude inventory dai adherence therapy att clinician rated tool developed group dai att scores showed significant correlation rho compared dai scale higher number variables associated att schizophrenia trs patients substance abuse significant predictor lower dai score respectively lower att score significantly associated first generation antipsychotic use positive symptoms impaired verbal fluency problem solving att dai score correlated score personal social performance scale overall att score predicted pharmacological psychopathological cognitive factors predictive psychosocial functioning therefore att measure may represent convenient practical tool evaluate schizophrenia patients adherence
article deals professional identity teachers arts contribute development analyze professional competences teachers importance communication emphasizing relevance reflective practice significant learning collaborative environmentthat take account social interaction negotiation knowledge arts disciplines promote social tools allow people build identities verbal nonverbal communication critical thinking exchange experiences
health related consequences stress hospital workers associated costs absenteeism high turnover increased need programs targeting stress population caring caregivers multimodal approach stress reduction designed address multidimensional nature stress hospital staff integrates five components cognitive somatic dynamic emotive hands flexible eight month format significant improvements demonstrated participants compared controls pre post scores maslach burnout inventory job related tension index perceived stress scale productivity scale general health questionnaire positive negative affect schedule visual analogue scales stress associated symptoms together significant reduction upper respiratory infections family doctor visits results suggest providing hospital staff multiple techniques addressing commonly encountered work stressors impacts positively health well significantly reduces stress burnout population
study concerned faithful maiden cult china offers perhaps compelling evidence regarding women involvement china reform women poetic laments provide rare glimpse emotions understanding roles identities meanings taiping rebellion taking yuan shou lamenting poem examine author challenges gender role shouldering household responsibilities male responding political unrest due outer world disrupted women laments challenge persistence ideology confucian womanhood also illustrate distinction women conception social reality thus study suggests ongoing consistent effort redefine limits women space results construction separate space private public domains represents arena public space private space overlap words privately managed space functions public domain writing immediate experience chaotic times women writing reflects transformation definition one often recognized sometimes neglected paper redefines understanding gender roles wartime literature promotes alternative strategy reading women literature
purpose purpose paper demonstrate assessment design used enhance students critical thinking subject concerned business enterprise systems study shows positive results favorable perceptions merit approach design methodology approach case study approach used examine problem based assessment task redesigned enhance students critical thinking study documents post graduate accounting students achievements including comparison results earlier version task data collected using surveys anonymous student comments findings case study reveals merit assessment design lay presenting students new material generated cognitive dissonance resolved rather applying subject knowledge new scenario requiring students assimilate harmonize materials encouraged think critically prior learning applied problem originality value congruent widespread calls employers professional bodies renewed focus importance developing critical thinking skills integral part higher education courses whilst achievement usually realized interdependently communication problem solving analysis critical thinking must fostered context specific professional knowledge study contributes knowledge students critical thinking may fostered added difficulty context involves focus role value technology
background multiphase steady state imaging contrast music acquires high resolution volumetric images beating heart uninterrupted ventilation aim evaluate diagnostic performance clinical impact music cohort neonates infants congenital heart disease chd methods forty consecutive neonates infants chd age range days years weight underwent cmr ferumoxytol enhancement single institution independently two readers graded diagnostic image quality intra cardiac structures related vascular segments music breath held cmra images using four point scale correlation cmr findings surgery imaging modalities performed patients clinical impact evaluated consensus referring surgeons cardiologists one point given five key outcome measures change overall management change surgical approach reduction need diagnostic catheterization improved assessment risk benefit planned intervention discussion parents accurate pre procedural roadmap results cmr studies completed successfully safely without adverse events four point scale average music image quality scores intra cardiac structures coronary arteries intra cardiac morphology vascular anatomy well visualized good interobserver agreement correspondence findings music surgery correlative imaging autopsy excellent average clinical impact score five patients discordant findings echo music catheter angiography music findings music shown accurate autopsy surgery decision undertake biventricular univentricular repair amended patients based music findings plans surgical approaches would involved circulatory arrest amended two surgical cases cases requiring procedural intervention music provided accurate dynamic roadmaps confident risk benefit assessments proposed interventions conclusions music cmr high clinical impact providing accurate high quality simple safe dynamic imaging cardiac vascular anatomy neonates infants chd findings influenced patient management positive manner
enduring misconceptions physical effects fiber gut led misunderstandings health benefits attributable insoluble soluble fiber review focus isolated functional fibers fiber supplements whose effects clinical outcomes readily assessed well controlled clinical studies review also focus three health benefits cholesterol lowering improved glycemic control normalizing stool form constipation diarrhea reproducible evidence clinical efficacy published small bowel clinically meaningful health benefits cholesterol lowering improved glycemic control highly correlated viscosity soluble fibers high viscosity fibers gel forming fibers glucan psyllium raw guar gum exhibit significant effect cholesterol lowering improved glycemic control whereas nonviscous soluble fibers inulin fructooligosaccharides wheat dextrin insoluble fibers wheat bran provide viscosity dependent health benefits large bowel two mechanisms drive laxative effect large coarse insoluble fiber particles wheat bran mechanically irritate gut mucosa stimulating water mucous secretion high water holding capacity gel forming soluble fiber psyllium resists dehydration mechanisms require fiber resist fermentation remain relatively intact throughout large bowel fiber must present stool mechanisms lead increased stool water content resulting bulky soft easy pass stools soluble fermentable fibers inulin fructooligosaccharide wheat dextrin provide laxative effect fibers constipating wheat dextrin fine smooth insoluble wheat bran particles making recommendations fiber supplement essential recognize fibers possess physical characteristics required provide beneficial health effect fiber supplements supported reproducible rigorous evidence one clinically meaningful health benefits
background common physicians work sick therefore important understand reasons behind previous research shown women men differ health health related behavior study examine gender differences among general practitioners work sick methods general practitioners working outpatient care swedish city participated study women response rate data obtained large web based questionnaire health organization within primary care two questions sickness presenteeism going work sick included life long past months five questions reasons controlled general health work family conflict demographic variables results female physicians reported sickness presenteeism often male physicians work family conflict mediated association gender sickness presenteeism women reported reasons related concern others workload strongly men men reported reasons related capacity money strongly women differences likely effects gender stereotyping different family responsibilities conclusions gender socialization gender stereotypes may influence work health related behavior sickness presenteeism related negative effects individuals organizational levels important managers health organizations understand reasons gender roles may influence prevalence sickness presenteeism reasons female male gps give behavior
view importance development field advanced technology transmission human life smart materials draws attention many researchers contribution interested synthesizing new smart material ceramic type based pzt doped site site solid solution pure oxides synthesized samples thermally treated degrees techniques ray diffraction xrd sem scanning electron microscopy used characterize microstructure crystallographic phase densities obtained samples determined weights volumes effect sintering temperature microstructure properties studied
electrodermal activity examined measure physiological arousal within naturalistic play context year old toddlers without autism spectrum disorder toddlers autism spectrum disorder found greater increases skin conductance level typical peers response administered play activities autism spectrum disorder group positive relationship observed restrictive repetitive behaviors skin conductance level increases response mechanical toys whereas opposite pattern observed passive toys preliminary study first examine electrodermal activity levels toddlers autism spectrum disorder play based naturalistic settings highlights potential electrodermal activity measure individual variability within autism spectrum disorder early development
paper presents novel development lower limb exoskeleton named caswell repetitive learning control design movement assistance caswell five degrees freedom per leg two driven linear single rod electrohydraulic actuators first mechanical structure embedded electronic system constructed respectively second incorporating systems rigid body electrohydraulic actuators complete dynamics caswell analyzed modeled third framework back stepping design repetitive learning control scheme presented address periodic tracking control lower limbs exoskeleton learning convergence closed loop system proved rigorously lyapunov way finally proposed controller implemented embedded electronic system via bit microcontroller tested developed caswell experimental results given demonstrate performance whole exoskeleton system
purpose productivity worldwide problem efforts made last three decades explore ways increase rate productivity construction sites purpose paper investigate state art productivity research present findings survey factors impair productivity site design methodology approach literature review structured five general headings pre construction activities activities construction managerial leadership issues motivational factors organizational factors total determinants extracted headings assessed main contractors findings literature review revealed advancement developing techniques tools improving productivity site need done invest technology innovation interview survey indicated factors associated pre construction activities namely experience selected site project managers design errors buildability design project planning communication leadership style procurement method critical factors influencing site productivity highly ranked factors mismanagement material work environment research limitations implications survey based main contractors thus generalized cover sectors building team designers engineers practical implications outcome research used provide professionals contractors guidance focussing acting upon controlling significant factors perceived influence construction labor productivity clp site originality value first reviewed state art trends construction productivity research second primary survey industry experts rank relative importance factors influence clp site
hereditary angioedema hae caused deficiency functional inhibitor cinh becomes clinically manifest attacks angioedema cinh main inhibitor contact system poor control local activation process system site attack believed lead formation bradykinin increases local vasopermeability mediates angioedema interaction receptor endothelium however several observations patients hae difficult explain pathogenic model claiming local activation process site angioedema attack therefore postulate alternative model angioedema attacks patients hae assumes systemic fluid phase activation contact system generate breakdown products interaction peptides endothelial receptors locally expressed affected tissues rather receptors constitutively expressed endothelium throughout whole body explains systemic activation process results local manifestations attack particular receptor induced endothelium inflammatory stimuli kinins cytokines meets specifications involved receptor pathogenic model discussed also provides explanation angioedema occur multiple sites attack hae attacks respond well modest increases circulating cinh activity levels inhibition fluid phase factor xiia kallikrein requires lower cinh levels inhibition activator bound factors
improving quality learning teaching always interest instructors fields study tremendous efforts end article learning teaching modules enhanced computer technology introduced approach based concept questioning scenario building aided interactive animation simulation rich graphical content modules engineering mechanics course covering fundamental topics statics strength materials dynamics prepared using proposed approach examples prepared modules presented design course module evaluation student perspective discussed based evaluations using questionnaires students inferred approach teaching learning helps students increase capacity understand instructors convey ideas conveniently wiley periodicals inc comput appl eng educ view article online wileyonlinelibrary com journal cae doi cae
automated systems based programmable logic controllers plc still applied discrete event systems des controlling monitoring industrial processes signals plc based control systems characterized physical input output signals coming going sensors actuators respectively direct contact production manufacturing process input subsystem plc consists sensor wiring physical inputs module present two kinds faults short circuit open circuit one signals process physical inputs causes faults control control algorithms behavior ladder diagram one five programming languages supported international electrotechnical commission iec iec standard remains used industry control algorithm design plc based systems paper proposes simulation validation control algorithms developed using petri nets order deal possible fault options short circuit open circuit physical inputs subsystem plc based control system one control algorithms analyzed order show advantages proposed approach
manufacturing engineering especially machining process definition reference plane first essential step within overall process reference plane applied component features processed reference basic plane process component clamped order resist processing forces several clamping systems available pneumatic magnetic systems magneto rheological systems depending stiffness component deformed due clamping forces stresses introduced effect neglected components high stiffness nearly rigid body behaviour however deformation low stiff components clamping forces sheet metals relatively large range addressed accuracy machining process due introduced elastic clamping stresses component reconfigure clamping phenomenon known springback focus work design clamping system flexible bodies order reduce springback enable high precision processing clamping system consists set supports adjust surface body without introducing stresses causing springback machining process number arrangement supports optimized function intensity position milling force geometrical mechanical properties body well functional unit clamping system cylindrical bodysliding nearly frictionless within pipe numerical simulation used configuration optimization developed clamping systems also used process freeform shaped bodies
poster must sufficiently informative convey suitable message reflects genuine characteristics topic social poster design deals social issues instantaneous events existing dynamic society therefore social poster design represent continuous consequences due social incident march magnitude earthquake hit east coast japan caused deaths missing injuries japanese prefectures reported national police agency japan dunbar though earthquake aftershocks tsunamis ended unfinished tragedy due continuous exposure radioactive contaminated water fukushima daiichi plant highly contaminated water accumulated roofs keeps flowed pacific ocean rains mccurry study aims present ongoing impact radioactive materials society social poster animated graphic randomly created background patterns within poster symbolize unfinished radioactive leaking circulation environment hence poster dynamically changing rather static graphic poster much like continuous changes occurring within environment due fukushima event middle red solid circle reflects japanese flag also symbolizes contaminated earth background patterns generated random motion oblique lines computer programming using processing open source programming language randomly generated graphic processing referred animated graphic exhibits unexpected radioactive exposures due fukushima daiichi nuclear disaster red circle represented japan earth suffered ongoing contamination depicted transparent red symbol patterns overlapped coexist noted printed version poster captured digital work found https dropboxusercontent com ulcosh dpmxw index html animated graphic shown dynamic poster informs audience ongoing social issue radioactivity leaking ocean since fukushima daiichi nuclear disaster unlike traditional static print poster raises audiences awareness empathy understanding tragedy using dynamic data affecting different reaction
analysis framework vehicle bridge dynamic interaction system turbulent wind proposed based relevant theory wind engineering dynamics considering fluctuating properties wind field stochastic wind velocity time history simulated auto regressive method terms power spectral density function wind field bridge represented three dimensional finite element model vehicle multi rigid body system connected springs dashpots detailed calculation formulas unsteady aerodynamic forces bridge vehicle derived addition form selection wind barriers applied windbreak measures newly built railways northwest china studied based suggested evaluation index suitable values height porosity rate wind barriers studied taking multi span simply supported box girder bridge case study dynamic response bridge running safety indices train traveling bridge without wind barriers calculated limit values train speed respect different wind velocities proposed according allowance values design code
novel titled cleft doris lessing reverses creation myths depicting women first humans although lessing presents women first humans close reading novel displays writer uses great extent traditional gender stereotypes gender roles aim paper discuss patriarchal implications cleft determine writer views concerning gender role development theories last decade life novel writer presents three periods beginning history humans first period laziness clefts first women emphasized presentation second third periods reader witnesses establishment gender roles gender role differentiation gender role differentiation presented consequence different innate natures females males characteristics females males depicted novel patriarchal gender stereotypical traits lessing may indicated gender stereotypical traits roles culturally constructed learned inherent characteristics females males may imply lessing may adopted sociobiological accounts gender role development least last decade life span
given relentless growing number mobile devices researchers pointed distributed computing environments clusters even computational grids could increase available resources scavenging devices capabilities however negatively impacts batteries study centralized job schedulers aim exploiting clusters mobile resources rather stable devices terms connection time schedulers outperform previous centralized scheduler finishing jobs amount energy also show schedulers perform competitively compared schedulers based job stealing difficult implement consume network resources hence energy elsevier rights reserved
consensual guidelines exist regarding management early effects radiotherapy preventive curative care strategies could adapted aim delay erythema limit complications improve patients comfort prevention involves encouraging patients take care skin avoid moisture frictions sun exposition dry soap rules seem insufficient products dressings solution cream could prescribed according individual risk patient preventive measures accentuated radiodermatitis appears topics indicated wound healing could applied care education dressing observation needs multidisciplinary approach improvements radiotherapy treatments methods techniques effective evolution radiodermatitis societe francaise radiotherapie oncologique sfro published elsevier masson sas rights reserved
studies examined relationship csf structural biomarkers cognitive function mci examined relationship cognitive function hippocampal volume cerebrospinal fluid csf beta tau patients mci patients assessed cognitive tasks cambridge neuropsychological test automated battery cantab geriatric depression scale functional activities questionnaire hippocampal volume measured using magnetic resonance imaging mri csf markers beta tau tau also measured worse performance wide range memory sustained attention tasks associated reduced hippocampal volume higher csf tau tau increased tau beta ratio memory tasks also associated lower ability conduct functional activities daily living providing link biomarkers memory performance functional outcome results suggest biomarkers tau strongly related cognitive performance assessed cantab implications early detection characterization incipient elsevier inc rights reserved
content creation realtime interactive systems difficult problem game development content creation pipelines major portion code base content creation major portion budget research environments choice rendering simulation systems frequently driven need easy use content authoring tools visualization problem compounded widely varying types data users desire visualize present visualization application creation framework incorporated visualization system enables measurement quantitative analysis tasks desktop immersive environments diverse input data sets
internal combustion engines inherently demand startup assistance perform autonomous functioning nevertheless common solution one century electric starter motor otto diesel cycles dynamic coupling system defined herein mechanical connection internal combustion engine starter motor evolved considerably since intermittent pinion ring gear interface adopted paper reviews conceptual design behind starting systems developed far focusing functional analysis proposes innovative concept preliminary study dynamic simulation using lumped parameters model implemented amesim also discussed potential aid proposed design based decision matrix method possible evaluate proposed design state art promising alternatives find real cost effective alternative existing concepts couple electric motor internal combustion engine patented dynamic coupling system proposed herein demonstrates potential evolve cost effective solution implement start stop systems worldwide contributing reduction pollution caused automotive vehicle emissions
rotor locations year outcomes firm ablation introductionpulmonary vein isolation pvi currently gold standard catheter ablation atrial fibrillation mechanism maintenance still controversial concept rapidly activating spiral rotors perpetuating led development several rotor mapping systems present experience focal impulse rotor modulation firm using electrode basket catheter computational system evaluate feasibility conjunction pvi treat methods resultstwenty five patients underwent firm mapping ablation treat paroxysmal basket catheter used rotor identification within right atrium left atrium radiofrequency energy applied around rotor core seconds rotor mapping ablation repeated rotors eliminated circumferential pvi performed three rotors identified per patient predominantly note left sided rotors located antrum twelve patients either termination termination conversion another rhythm cycle length prolongation rotor ablation single procedure patients free atrial tachyarrhythmia follow period months conclusionearly results suggest firm ablation terminate significant number patients rotors frequently identified pvs antrum supporting pvi cornerstone ablation
use remote sensing proton aurora image fuv imager magnetopause aurora global exploration far ultraviolet spectrographic imaging instrument radar measurements ionospheric convection superdarn super dual aurora radar network facility estimate open magnetic flux earth magnetosphere reconnection rates dayside magnetopause magnetotail intervals steady magnetospheric convection smc find smc intervals occur relatively high open magnetic flux average similar gwb standard deviation similar gwb often found nearly steady magnetic flux opening closure rates approximately balance around average standard deviation find residence timescale open magnetic flux defined ratio open magnetospheric flux flux closure rate roughly smcs interestingly number approximately deduced discussion length tail published dungey assuming solar wind speed similar also infer enhanced convection velocity tail driving open magnetic flux nightside reconnection site compare results previously published studies order identify different magnetospheric modes ordered increasing open magnetic flux reconnection rate quiet conditions smcs substorms important overlap last two sawtooth intervals
chronic cancer pain serious complication malignancy treatment currently comprehensive universally accepted cancer pain classification system exists clarity classification common cancer pain syndromes would improve clinical assessment management moreover evidence based taxonomy would enhance cancer pain research efforts providing consistent diagnostic criteria ensuring comparability across clinical trials part collaborative effort analgesic anesthetic addiction clinical trial translations innovations opportunities networks acttion american pain society aps acttion aps pain taxonomy initiative worked develop characteristics optimal diagnostic system establishment characteristics working group consisting clinicians clinical basic scientists expertise cancer cancer related pain convened generate core diagnostic criteria illustrative sample chronic pain syndromes associated cancer bone pain pancreatic cancer pain models pain related tumor treatment chemotherapy induced peripheral neuropathy systematic review synthesis conducted provide evidence dimensions comprise cancer pain taxonomy future efforts subject diagnostic categories criteria systematic empirical evaluation feasibility reliability validity extension cancer related pain syndromes perspective acttion aps chronic cancer pain taxonomy provides evidence based classification prevalent syndromes namely malignant bone pain pancreatic cancer pain chemotherapy induced peripheral neuropathy taxonomy provides consistent diagnostic criteria common features comorbidities consequences putative mechanisms potentially serious cancer pain conditions extended applied cancer related pain syndromes authors published elsevier inc behalf american pain society
servo velocity sensors svs provide reliable accurate velocity acceleration measurements civil infrastructures bridges buildings however svss communicate data processing unit wired cable impedes time continuous monitoring applications using svs study mote integrated converter module designed implemented bridge svs wireless sensor networks wsn proposed wsn enabled svs verified comparing measured results purchased commercial system bridge scour experiment applied corridor bridge vibration measurement employed suspension bridge vibration test several guidelines deployment installation wsn enabled svs vibration monitoring application carefully addressed suggested optimized deployment scheme reduce packet loss efficiently wsn enabled svs applied continuous monitoring applications definitely
ecco topical review european crohn colitis organisation ecco focuses epidemiology pathophysiology diagnosis management outcome two common forms inflammatory bowel disease crohn disease ulcerative colitis elderly patients objective reach expert consensus provide evidence based guidance clinical practice
recent years pollution receiving water induced urban stormwater runoff gained considerable attention meanwhile rainwater also potential valuable water resource may effectively mitigate increasing water shortage present study distributions transport nutrients heavy metals different stormwater runoff two residential communities site effect drainage systems discussed detail site combined drainage system located old district featured lot big manufacturing chemical factories suburb differently site separate system situated new district occupied small shops residential quarters results indicated air quality significant influence factor reference index decision making rainwater harvesting reuse nutrients anthropic activities contributed adequately ammonia nitrogen total phosphorus road runoff sewer overflows especially site combined drainage system however roof runoff presented highest event mean concentrations emc nitrate nitrite nitrogen probably due high runoff coefficient roof low interference human activities dry deposition concentrations showed similar variation pattern although small differences owing erosion metal materials rooftops street lamps compared standards drinking water quality china direct rainfall site could harvested utilized potential drinking water supply perspective studied parameters site least must removed reuse results obtained research would provide important assistance support urban rainwater reuse well runoff pollution control
suffix arrays fundamental full text index data structures importance broad spectrum applications fields bioinformatics burrows wheeler transform based lossless data compression information retrieval work propose implement two massively parallel approaches graphics processing unit gpu based two classes suffix array construction algorithms first parallel skew makes algorithmic improvements previous work deo keely achieve speedup work second hybrid skew prefix doubling implementation first kind gpu achieves speedup osipov prefix doubling skew implementation large datasets implementations rely two efficient parallel primitives merge segmented sort theoretically analyze two formulations suffix array construction algorithms show performance comparisons large variety practical inputs conclude novel use efficient segmented sort prefix doubling competitive skew gpu also demonstrate effectiveness methods implementations burrows wheeler transform parallel full text minute space index pattern searching copyright john wiley sons ltd
background aim study assess premorbid moderates association measures clinical severity neurocognitive psychosocial functioning euthymic patients bipolar disorder methods one hundred nineteen outpatients forty healthy controls included length illness number previous hypo manic depressive episodes episode density history psychosis assessed clinical severity performances verbal memory attention executive functions well level psychosocial functioning used outcomes results negative relationship number hypo manic episodes performance executive functions decreased function higher values premorbid influences premorbid found association clinical severity measures neurocognitive psychosocial functioning conclusions premorbid might moderate relationship number hypo manic episodes executive functioning bipolar disorder possible interpretations finding discussed
alterations general intellectual ability social cognition schizophrenia core features disorder evident illness onset persistent throughout course however previous studies examining cognitive alterations siblings discordant schizophrenia yielded inconsistent results present study aimed investigate nature association facial emotion recognition general applying genetically sensitive cross trait cross sibling design participants total patients unaffected siblings controls assessed using benton facial recognition test degraded facial affect recognition task dfar wechsler adult intelligence scale iii patients lower altered facial emotion recognition comparison groups healthy siblings controls significantly differ dfar performance siblings exhibited intermediate angry facial expression recognition cross trait within subject analyses showed significant associations overall dfar performance participants within trait cross sibling analyses found significant associations patients siblings overall dfar performance suggesting familial clustering finally cross trait cross sibling analyses revealed familial covariation facial emotion recognition siblings discordant schizophrenia indicating familial etiology traits important phenotypes genetic studies potential early clinical markers schizophrenia spectrum disorders elsevier ireland ltd rights reserved
faces voices isolation prompt consistent social evaluations however human interactions involve seeing talking another person main goal investigate facial vocal information combined reach integrated person impression study asked participants rate faces voices separately perceived trustworthiness attractiveness dominance previous studies relied stimuli extra vocal information verbal content prosody may confounded voice based effects prevent unwanted influences used brief neutral vowel sounds voices like faces led formation highly reliable impressions voice trustworthiness correlated voice attractiveness mirroring relation face trustworthiness attractiveness correlate voice dominance inconsistent possibility face voice evaluations indicative real character traits found positive correlations judgments trustworthiness dominance based faces judgments based voices also correlation face attractiveness voice attractiveness study asked participants evaluate male targets seeing faces hearing voices faces voices contributed equally judgments trustworthiness combined produce significant interaction effect attractiveness faces given weight voices possibly due predominantly visual character attractiveness concept interaction effect dominance reverse pattern true voices larger effect faces final judgments case auditory cues may perceived reliable strong links voice pitch masculinity dominance
estimated youth primary care exhibit behavioral symptoms may underdetected screeners identify risk base symptoms alone irrespective functional impairment address issue pediatric symptom checklist psc widely used symptom screener combined functional impairment current behavioral services enrollment items form pediatric behavioral health screen pbhs assessed compared full child behavior checklist cbcl total youth years age administered screener cbcl areas receiver operating curves approached exceeded analyses reflecting excellent classification accuracy almost false negatives observed among currently untreated cases functional impairment differential item functioning found performance psc pediatric primary care behavioral health screener supported previous research additional functional impairment items form pbhs appeared useful particularly interpreting borderline range scores
efficient simplified method proposed time domain design industrial proportional integral derivative pid controllers lead lag compensators high order single input single output siso systems proposed analytical method requires trial error steps lead lag compensator design time domain using root locus method practical pid controller design method obtained based corresponding lead lag compensator give required time domain specification simulation studies carried illustrate control performance controllers proposed method proposed pid controller lead lag compensator directly satisfied time domain control specifications damping ratio maximum overshoot settling time steady sate error without trial error steps suggested algorithm easily integrated toolbox commercial software matlab
analyze large scale real world data various attributes many real world data network traffic logs web data social networks knowledge bases sensor streams multiple attributes represented multi dimensional arrays called tensors analyzing tensor tensor decompositions widely used many data mining applications detecting malicious attackers network traffic logs source destination port number timestamp finding telemarketers phone call history sender receiver date identifying interesting concepts knowledge base subject object relation however current tensor decomposition methods scale large sparse real world tensors millions rows columns fibers paper propose haten distributed method large scale tensor decompositions runs mapreduce framework careful design implementation haten dramatically reduce size intermediate data number jobs leading achieve high scalability compared state art method thanks haten analyze big real world sparse tensors handled current state art discover hidden concepts
compelling evidence gender differences authoritarianism self esteem mental disorders found psychology literature however researchers yet identified etiologies traumatology perspective proposes gender discrimination contributes differences promotes internalized male superiority enhanced self esteem increase authoritarianism impact men behavior promotes internalized gender inferiority women decreased self esteem predicting internalizing disorders samples sample women sample men using path analysis tested perspective men sample externalizing accounted variance predicted internalized male superiority increased externalizing addiction psychoticism authoritarianism selfesteem decreased internalizing women sample predicted increased internalized female inferiority internalizing lowered self esteem internalizing accounted variance results identified etiologies dynamics contribute gender differences discussed implications findings advocating gender equality
evidence centrality loss event well reduced self concept clarity involved emotional problems death loved one one issue still unexplored relative importance two concepts predicting bereavement outcome current study examined degree concepts contribute emotional distress loss concurrently longitudinally data available individuals bereaved within previous half year completed measures prolonged grief posttraumatic stress depression inclusion study months later loss centrality self unclarity associated three outcome measures cross sectional analyses longitudinal analyses indicated loss centrality predicted symptom levels prolonged grief self unclarity predicted symptom levels depression loss centrality self unclarity associated posttraumatic stress months baseline implications findings discussed
objective studywas explore relationship menopausal status attitudes toward menopause aging identified bengali hindu women aged years early perimenopausal late perimenopausal early postmenopausal late postmenopausal west bengal india information attitudes toward menopause aging collected march july using ten agree disagree statements three positive four negative restwere neutral used positive negative statements analyses participants given three response options statement agreed disagreed felt neutral agreement positive statements disagreement negative statements scored converse responses scored neutral responses scored thus total attitude score participant ranged additionally data sociodemographic reproductive variables menopausal symptoms perceptions toward menopause also collected multivariable analyses ancova showed postmenopausal women positive attitudes toward menopause aging perimenopausal women providing balanced information menopause aging might help foster positive attitudes toward menopause
optimal digital autopilot needed control roll aircraft arbitrary unmeasured disturbances addressed paper autopilot achieve desired lateral motion control via minimizing upper bound absolute value difference given true roll angles ensured means two digital optimal controllers type main result consists establishing fact controller robust presence parametric nonparametric uncertainties
meet specific requirements standard training knowledge capability excellence engineers mechanical design manufacturing automation major advanced concepts including farther training professional ability project teaching adopted construct systems core professional knowledge module theory teaching course system practical teaching system cultural professional quality training systems whole framework curriculum system corresponding credit requirements etc substituted post exercitation training plan senior specific requirements graduation design stated finally order cultivate abundant advanced manufacturing technology high ranking engineering technology talents awareness project effective approaches organize teaching team double teacher structure analyzed
reconfigurable integrator differentiator circuits based current follower presented essential realizing configurable analog blocks cabs field programmable analog arrays fpaas proposed circuits provide functional reconfigurations components reuse functions provide flexibility area filter design within cab architectures circuits based current follower potential operate higher frequency ranges offer improved linearity counterparts based operational amplifier transconductance amplifier respectively switches used signal path order avoid degrading frequency response proposed circuits cmos current follower realization compatible implementation proposed designs adopted experimental results obtained standard cmos process provided elsevier ltd rights reserved
hadamard haar transform emphasized research attention application spectral analysis bandwidth compression digital filter design paper modelling hadamard haar transform developed multistage interconnection network min based architecture signal flow graph existing algorithm analysed flow graph mapped possible implementation omega connected multiprocessor modified computational distribution suggested improved efficiency parallel domain modified transform modelled omega network performance comparison carried original modified algorithm modelling results compared results obtained mapping algorithm shared bus mesh connected architecture results expressed closed form formulae published elsevier science
microrna short non coding rna mediator post transcriptional regulation gene expression addition uncoupling proteins ucps regulate thermogenesis metabolic energy balance decrease reactive oxygen species production microrna ucp expression altered cancer cells low power laser wavelength frequency fluence emission mode deternube photobiological responses basis low level laser therapy studies mirna ucp mrna levels low level laser exposure cancer cells work evaluate micrrna mir mir ucp mrna levels human breast cancer cells exposed low level lasers mda human breast cancer cells exposed low level red infrared lasers total rna extracted cdna synthesis mrna levels real time quantitative polymerase chain reaction evaluated data show mir mir relative levels altered ucp mrna relative levels increased mda human breast cancer cells exposed low level red infrared lasers fluences used therapeutic protocols
background occurring borderline personality disorder bpd features marked impact treatment patients mood disorders overall high neuroticism childhood traumatic experiences tes insecure attachment plausible aetiological factors bpd however relationship bpd features specifically among patients mood disorders remains unclear investigated relationships among unipolar bipolar mood disorder patients methods part helsinki university psychiatric consortium study mclean screening instrument msi experiences close relationships revised ecr short five trauma distress scale tads filled patients mood disorders psychiatric care correlation coefficients total scores scales dimensions estimated multivariate regression mra mediation analyses conducted results spearman correlations strong rho total scores msi neuroticism moderate rho msi tads well msi ecr attachment anxiety mra young age neuroticism tads predicted scores msi ecr attachment anxiety mediated relationships tads msi limitations cross sectional questionnaire study conclusions found moderately strong correlations self reported bpd features concurrent high neuroticism reported childhood traumatic experiences attachment anxiety also among patients mood disorders independent predictors bpd features include young age frequency childhood traumatic experiences high neuroticism insecure attachment may partially mediate relationship childhood traumatic experiences borderline features among mood disorder patients
hereditary angioedema resulting inhibitor deficiency inh hae rare autosomal dominant disorder characterized recurrent attacks edema formation management pregnant patients inh hae often challenge physician limited experience novel therapies plasma derived nanofiltered inh pnfc inh recommended therapeutic option pregnancy year old female patient type inh hae pregnancy confirmed sixth week gestation period patient received bradykinin receptor antagonist icatibant five occasions acute treatment experienced attacks received vials pnfc inh pregnancy patient gave birth healthy baby side effects detected either treatment reports published date multiple dosing icatibant first trimester pregnancy therapy proved effective free maternal fetal adverse effects
growing body research suggests bipolar spectrum disorders bsds associated high aggression however little research prospectively examined aggression may affect time onset hypomanic manic versus major depressive episodes longitudinal study tested hypothesis aggression would prospectively predict shorter time onset hypomanic manic episodes longer time onset major depressive episodes based behavioral approach system theory bsds young adults diagnosed cyclothymia bipolar disorder bipolar disorder otherwise specified followed every months average years participants completed measures depressive manic symptoms family history mood disorder impulsivity aggression baseline followed prospectively semistructured diagnostic interview assessments hypomanic manic major depressive episodes treatment seeking mood problems cox proportional hazard regression analyses indicated overall physical verbal aggression predicted longer time major depressive episode onset even controlling baseline depressive manic symptoms family history mood disorder treatment seeking mood problems impulsivity aggression however significantly predict time onset hypomanic manic episodes controlling covariates findings suggest approach related behaviors may utilized delay onset major depressive episodes among people bsds
monoamine oxidase maoa gene important candidate gene human behavior encodes enzyme regulating metabolism key neurotransmitters regulatory mechanisms maoa gene dogs yet elucidated measured maoa gene transcription analyzed vntr genotype methylation status gene promoter region different dog breeds determine whether maoa expression correlated maoa genotype epigenetic modification dogs found brain specific expression maoa gene different transcription levels different dog breeds including beagle sapsaree german shepherd also robust association dna methylation gene promoter mrna levels however tandem repeats observed near transcription start site variable indicating correlation canine maoa activity results show differential dna methylation maoa promoter region may affect gene expression modulating promoter activity moreover distinctive patterns maoa expression dna methylation may involved breed specific individual behavioral characteristics aggression behavioral phenotypes related different physiological neuroendocrine responses elsevier rights reserved
objective previous survey research indicates women men experience reduced sexual pleasure using condoms especially compared nonbarrier family planning methods study seeks explore experiences reduced pleasure depth affect contraceptive method decisions use study design depth interviews men women ages years united states contraceptive decisions use analyzed results men women complained way condoms interfered sexual pleasure several women men complained condoms actually hurt majority couples least one member reported disliking condoms hormonal methods intrauterine devices general side effects usually one important reasons women continued discontinued methods sexual side effects reported conclusions interfering sexual pleasure appears important reason men women use condoms public health practitioners recognize limitations condoms contraceptive technology despite problems general side effects women men prefer hormonal methods condoms implications study provides depth descriptions showing young adult men women united states use condoms less condoms interfere sexual pleasure although women often say experience general negative side effects hormonal birth control usually perceive sexual side effects hormonal birth control since young heterosexual adults usually perceive much greater risk pregnancy sexually transmitted infections mostly perceive hormonal birth control greatly superior contraceptive option compared condoms elsevier inc rights reserved
urologic kidney problems common women across life span affect daily life including physical activity sexual relations social life future health urological health women still understudied underlying mechanisms female urological dysfunctions fully understood society women health research swhr recognized need roundtable discussion researchers clinicians would define current state knowledge gaps recommendations future research directions transform women urological health report summarizes discussions focused epidemiology clinical presentation basic science prevention strategies efficacy current therapies experts around table agreed set research education policy recommendations potential dramatically increase awareness improve women urological health stages life
domestic violence children dvac interferes psychological development leading sequels manifest persist adulthood physical evidences domestic violence easily observed orofacial complex becoming eventually detected dentists present systematic literature review aimed investigate perception knowledge attitude dentists towards detection management dvac cases systematic search performed data bases pubmed sciencedirect lilacs scielo googlescholar opengrey cross sectional articles assessing perception knowledge attitude dentists facing potential cases dvac selected restriction language time publication status considered search resulted articles fit eligibility criteria knowledge detecting cases dvac obtained undergraduation course classified dentists articles insufficient suspecting cases involving domestic violence dentists articles considered reporting competent authorities however dentists sure authorities articles attention must given forensic education dentistry specifically proper training necessary support dentists detection management pediatric patients domestic violence elsevier ltd faculty forensic legal medicine rights reserved
first impressions profoundly influence attitudes behavior toward others however little known whether degree cognitive processes underlie impression formation depend domain available information target person investigate neural bases influence verbal compared nonverbal information interpersonal judgments identified brain regions bold signal parametrically increased increasing strength evaluation based either short text vignettes mimic gestural behavior verbal stimuli increasing strength subjective evaluation correlated increased neural activation precuneus posterior cingulate cortex pcc similar effect observed nonverbal stimuli amygdala findings support assumption qualitatively different cognitive operations underlie person evaluation depending upon stimulus domain processing nonverbal person information may strongly associated affective processing indexed recruitment amygdala verbal person information engaged pcc related social inferential processing elsevier inc rights reserved
individuals apply different processing strategies deal situations encounter one central question social cognition research refers factors determine reliance different processing strategies parting functional perspective holds processing strategies need adjusted requirements situation argue individuals mood carries information benign versus problematic nature situation thus mood regulate cognitive processing focusing mental abstraction propose positive mood contributes processing style characterized reliance prior knowledge form general knowledge structures whereas negative mood elicits processing style characterized attention details consideration new situation specific information
field hydrological modelling global automatic parameter calibration hot issue many years among automatic parameter optimization algorithms shuffled complex evolution developed university arizona sce successful method stably robustly locating global best parameter values ever since invention sce profession suddenly consistent way calibrate watershed models however computational efficiency sce significantly deteriorates coping big data complex models purpose solving efficiency problem recently emerging heterogeneous parallel computing parallel computing using multi core cpu many core gpu applied parallelization acceleration sce original serial proposed parallel sce compared test performance based griewank benchmark function comparison results indicated parallel sce converged much faster serial version optimization accuracy serial version promising application prospect field fast hydrological model parameter optimization
purpose study investigate therapeutic effect denosumab anti rankl monoclonal antibody treatment bone loss indolent systemic mastocytosis ism patients intolerant bisphosphonates four patients underwent upon informed consent treatment denosumab administered subcutaneously every months regimen used postmenopausal osteoporosis bone mineral density bmd measured lumbar femoral sites baseline year terminal telopeptide collagen type ctx bone alkaline phosphatase balp tryptase serum level determined baseline months fasting blood samples withdrawals bmd increased significantly sites months patients important decrease serum ctx lesser extent balp serum levels denosumab treatment decrease serum tryptase level observed patients adverse events new fractures occurred denosumab seems valid alternative treatment bone loss ism rankl might key importance pathogenesis ism bone involvement
racial stereotyping found handicap african american latino candidates negative ways less clear racial stereotypes may change fortunes asian candidates paper explores candidacies asian americans experiment run amazon mechanical turk well real world evaluations asian american candidates using cooperative congressional elections study experiments find asian candidates significantly better white candidates across different biographical scenarios conservative liberal foreign find contrary expectations asian candidates significantly disadvantaged immigrant foreign born experimental results mirror observational results show asian democrats significantly advantaged even compared whites results indicate asian candidates america face set racial political stereotypes unique racial subgroup
white matter microstructures axonal density average diameter crucial normal function central nervous system cns closely related axonal conduction velocities conversely disruptions microstructural features may result severe neurological deficits suggesting noninvasive mapping could important step towards diagnosing following pathophysiology whereas diffusion based mri methods proposed map features typically entail application powerful gradients rarely available clinic extremely long acquisition schemes extract information parameter intensive models study suggest simple time efficient multi gradient echo mge mri used extract axon density susceptibility driven non monotonic decay time dependent signal show theoretically simulations non monotonic signal decay occur multi compartmental microstructures axons extra axonal spaces used simple model microstructure axons parallel main magnetic field axonal density extracted experimentally demonstrate vivo rat spinal cords different tracts characterized different microstructures clearly contrasted using mge derived maps quantitative results compared ground truth histology reflect axonal fraction though bias evident bland altman analysis well extra axonal fraction estimated results suggest model oversimplified yet time evidencing potential usefulness approach map underlying microstructures using simple time efficient mri sequence show simple general linear model predict average axonal diameters four model parameters map average axonal diameters spinal cords clearly modelling theoretical developments necessary conclude salient microstructural features extracted simple snr efficient multi gradient echo mri paves way towards easier estimation microstructure vivo elsevier inc rights reserved
background aim epicardial adipose tissue eat easily quantifiable visceral adipose tissue closely associated cardiometabolic disease including heart failure preserved left ventricular ejection fraction body fat distribution metabolism different men women evaluated sex difference eat thickness relationship cardiac function methods results total consecutive patients men mean age years enrolled conventional echocardiography performed eat thickness measured perpendicularly right ventricular free wall end systole mean eat thickness patients eat thickness associated patient age body mass index presence hypertension eat thickness different sex patients younger years men women however among patients aged years older eat thickness significantly greater women men men women function represented significantly related eat thickness women beta lateral beta conclusion eat thickness greater women men years old relationship function significant women greater increase eat thickness elderly women menopause might partially account difference italian society diabetology italian society study atherosclerosis italian society human nutrition department clinical medicine surgery federico university published elsevier rights reserved
allergic rhinitis long considered predominantly involve actions cells relatively small contributions cells recent years discovery regulatory treg cells rendered balance paradigm complex expanded understanding pathogenesis key cytokine produced cells known induce allergen specific cell activation eosinophil neutrophil accumulation serum ige production asthma features may play important roles best knowledge studies assessed feasibility using antagonists treat thus principal objectives present study first determine status treg cells nasal mucosa mouse model second investigate effects cells therapeutic efficacy anti antibodies abs context anti abs given intranasally challenge balb mice ovalbumin ova induced measured numbers nasal rubbing motions sneezes eosinophil neutrophil levels treg parameters nasal mucosa anti abs markedly reduced number nasal rubbing motions sneezes decreased eosinophil neutrophil infiltration reduced responses increased treg response anti treatment protects results improve understanding pathogenesis may lead development novel therapeutic approaches management condition
ability solve problems critical skill undergraduate engineering curricula students capacity problem solving complicated fact higher level reasoning skills including capacity abstraction innate person mid twenties later results exploratory study looked students episodes reasoning solving problems sophomore level electrical circuits course presented students problem solving attempts analyzed using representation mapping framework developed hahn chater based store representations knowledge applied framework distinguishes similarity rules based cognitive processes accounts memory bank rules based similarity based prototype types reasoning students asked think aloud solving specific problems selected course instructor interviews recorded transcribed analyzed detail identify types reasoning degree abstraction students problem solving attempts study demonstrated representation mapping useful framework studying students problem solving skills electrical engineering
deterministic boltzmann model equation solver called dugksfoam developed framework open source cfd toolbox openfoam solver adopts discrete unified gas kinetic scheme guo shakhov collision model validated simulating several test cases covering different flow regimes including one dimensional shock tube problem two dimensional thermal induced flow three dimensional lid driven cavity flow solver features parallel computing ability based velocity space decomposition different physical space decomposition based approach provided openfoam framework two decomposition approaches compared two three dimensional cases parallel performance improves significantly using newly implemented approach speed two orders magnitudes observed using cores small cluster program summary program title dugksfoam program files doi http doi org zwntcfw licensing provisions mit license programming language external routines libraries openfoam http www openfoam org nature problem solving boltzmann equation shakhov model explicitly solution method discrete unified gas kinetic scheme dugks restrictions symmetric boundary condition applied walls parallel axis directions elsevier rights reserved
analytical solution realm two dimensional linear elasticity theory presented soil reaction around laterally loaded cylindrical pile segment surrounded annular zone soft elastic material plane strain conditions end seminal model extended account different boundary conditions interfaces separating annular zone pile outer material analytical closed form solutions derived stiffness system stress strain fields annular zone following combinations shear boundary conditions perfectly bonded interfaces perfectly smooth interfaces perfectly bonded inner perfectly smooth outer interface perfectly smooth inner perfectly bonded outer interface shown thin thick soft zones stiffness system becomes independent shear boundary conditions predictions model compared two models based strength materials theory three dimensional effects numerical simulation aspects discussed american society civil engineers
reactive traits sensitivity punishment sensitivity reward assumed involved development eating disorders eds studies examine whether levels traits differ diagnoses without taking variables account however vulnerability theories psychopathology posit risk psychopathology depends interaction reactive traits self regulatory traits effortful control present objective examine moderating role association eating styles restrained eating emotional eating external eating possible precursors adolescents obtain objective community sample adolescents female years old recruited self report questionnaires used measure level eating styles subsample female colour word stroop task conducted additional behavioural measure hierarchic linear regressions performed separately boys girls examine interactions well gender differences interactions evidence interactions reactive regulative traits explaining restrained emotional eating girls also several main effects found boys eating styles girls restrained eating implications findings future research screening prevention programs discussed elsevier ltd rights reserved
mekong delta vietnam piped water supply stations intensively built reach millennium development goal mdg provide safe clean drinking water resources communities however studies focusing effectiveness supply stations reaching goals scarce date water samples water supply stations collected june october water samples analyzed general parameters salinity nutrients metal loid microbial indicator bacteria compared world health organization vietnamese drinking water guidelines addition household interviews conducted investigate connection rate piped water people perceptions regarding piped water supplies results show water guidelines exceeded min turbidity max ftu max max microbial indicator bacteria max total coliform cfu moreover half interviewed households access piped water supply use supply source drinking water due high connection fees preference water sources iii perceived poor quality quantity study shows maintenance distribution water supply stations significantly improve order piped water become reliable drinking water source additionally alternatives rainwater harvesting decentralized treatment facilities also considered
understanding thermal hydraulics basic phenomena application nuclear power plants vital safe well efficient design operation thermal hydraulics two phase flow heat transfer nuclear applications studied roughly years current body knowledge extensive yet remain safety issues licensing new light water reactor designs new analysis methodologies rarely simple due state art reactor thermal hydraulics well perspective regulator case nuclear regulatory commission nrc toward field study paper discusses state art nuclear thermal hydraulics regulator unique role perspective view current challenges discussion meant point regulator perspective shaped hopefully provide guidance fulfilling research needs future applications may need nrc review
high speed machine design becoming important due advantages high power density small size flux switching permanent magnet fspm machines simple rotor design without windings pms makes apt high speed operation low pole topology fspm machine desirable keep operational frequency minimum lowest slot pole combination three phase fspm machine stator slot rotor pole topology research aims investigating analyzing cause unbalance flux linkage back electromotive force waveforms fspm machine influence rotor pole width stator tooth width magnet length analyzed find optimum design variable results useful making low pole fspm topology amenable high speed operations
objective determine feasibility reliability validity nails ultrasonography psoriatic arthritis outcome measure methods pilot prospective single centre study eight ultrasonography parameters mode power doppler concerning distal interphalangeal dip joint matrix bed nail plate intraobserver inter observer reliability evaluated seven quantitative parameters icc kappa correlations ultrasonography clinical variables searched assess external validity feasibility assessed time carry examination percentage missing data results twenty seven patients psoriatic arthritis age years disease duration years included presented nail involvement ultrasonography physical examination seven quantitative parameters except synovitis dip joint mode synovitis dip joint revealed ultrasonography correlated total number clinical synovitis doppler nail matrix bed doppler matrix correlated vas pain asdas crp clinical enthesitis significant correlation found nail thickness conclusion feasibility reliability ultrasonography nail psoriatic arthritis appear satisfactory among eight parameters evaluated power doppler matrix correlated local inflammation dip joint bed vas pain could become interesting outcome measure provided also sensitive change societe francaise rhumatologie published elsevier masson sas rights reserved
screen climate graphic violence commonly excoriated social effects increasingly matter violent computer graphics cgi article returns christian metz landmark essay trucage trick effects rethink terms post filmic mode digitage rather traditional montage
infant vocal capacity develops significantly first year life research suggests early measures pre speech development canonical babbling volubility differentiate typical versus disordered development study offers new contribution comparing early vocal development infants fragile syndrome typical development results suggest infants fragile syndrome produce fewer syllables significantly lower canonical babbling ratios compared infants typically developing furthermore particular measures babbling strong predictors group membership adding evidence regarding possible utility markers early identification
objectives examine association family factors oral health behaviors children compare permanent residents migrant children methods total children grades elementary schools parents beijing guangzhou china selected multistage stratified cluster random sampling questionnaires constructed study self completed children parents collect information children oral health behaviors cohb parents modeling behaviors pmb parents direct controlling behaviors pdcb parents indirect controlling behaviors picb parents oral health knowledge attitudes pohka children oral health knowledge attitudes cohka correlation analysis path analysis used explore correlation cohb pmb well effects family factors socioeconomic status ses pmb pdcb picb pohka cohb results considering participants rates behavioral similarities parents children showing statistical significance family factors included pmb ses picb pohka demonstrated positive relationships cohb standardized coefficients residents migrants respectively family ses associated cohb directly indirectly similar degree migrants relationship cohka cohb greater pmb cohb cohb scores higher younger children residents relationship pmb cohb greater cohka cohb cohb scores slightly higher older children indirectly influenced increases cohka conclusions parents behaviors shared relatively high similarities cohb family factors associated cohb greatly relationship pmb cohb less cohka cohb migrants association family factors cohb disadvantaged populations considered designing children health education programs
flood area mapping integral part disaster management operation gets value details inundated region made available real time mode well much required temporal information shared disaster mitigation authorities right time challenges real time flood area mapping operations met spaceborn synthetic aperture radar sar technology capable capturing critical information large hard reach territories weather time situations mapping flood related information sar images require much attention pixels associated inundated regions exhibit similar reflectance major part pixels associated high altitude region shadow runway broad road networks challenges addressed worldwide researchers help image processing functions many sar image based flood area mapping models take advantages various image classification approaches well integrating multiple image processing functions mainly differentiate inundated pixels pixels exhibits similar reflectance mapping accuracy enhanced paper dedicated understanding documenting various significant sar image based flood area mapping models highlighting strengths significant sar image bases flood area mapping models discussed respective references used young researchers interested willing work sar image based flood area mapping techniques
abnormalities large scale brain networks recently reported dyslexia however remains unclear whether abnormalities congenital due dyslexia per arise later development structural magnetic resonance imaging data chinese reading disabled age matched typically developing children used construct cortical thickness sensitive postnatal development surface area sensitive prenatal development networks thickness network compared showed reduced nodal network properties degree betweenness left hemisphere along enhanced nodal properties mainly right hemisphere surface area network compared demonstrated lower nodal properties posterior brain regions higher nodal properties anterior brain regions furthermore hubs thickness surface area networks distributed frontal areas less distributed parietal areas whereas showed opposite pattern altogether findings indicate aberrant structural connectivity dyslexic individuals due late developmental effect reflected altered thickness network may also congenital effect prenatal development reflected altered surface network elsevier inc rights reserved
fast discovery association rules millions transactions variety large databases become major challenge data mining domain frequent itemsets frequent closed itemsets key sources mining association rules association rules mined efficiently lattice itemsets non redundancy accuracy time efficiency memory usage factors need considered developing algorithms order extract meaningful association rules paper propose efficient bit vector approach exploits dual properties tidset superset information item set order mine frequent closed itemsets lattice structure introduce new memory efficient data structure called dynamic superset bit vector establish relationship among frequent closed itemsets lattice novelty approach effectively uses dual data structures called dynamic bit vector dynamic superset bit vector jointly order reduce search space eliminate generators non closed itemsets proposed approach efficiently builds subset superset relationship among closed itemsets lattice structure bottom manner extensive experiments using real life datasets pervasive performance comparison existing works prove efficiency scalability proposed approach elsevier ltd rights reserved
ethylene refrigeration system light olefins production plant investigated using conventional advanced exergoeconomic analyses advanced analysis investment exergy destruction costs system components divided endogenous exogenous avoidable unavoidable parts improve knowledge refrigeration system results exergoeconomic analysis represent total cost column compressor compressor multi stream heat exchanger mshe larger components results advanced exergoeconomic analysis reveal total costs components endogenous reduced column compressor increasing efficiency two components investment exergy destruction costs decreased large amounts endogenous exergy destruction cost components represent interactions components main reason exergy destruction therefore appropriate strategy enhancement system efficiency profitability improve performance based results column compressor highest priority improve performance sensitivity analysis parameters important operating variables also investigated elsevier ltd rights reserved
parents important source support facilitating physical activity children youth disabilities cywd approximately parents report using internet search information regarding children health study examined theoretical content physical activity information contained publicly available web sites targeting parents cywd web sites amassed using google combination various search terms predetermined inclusion criteria web sites coded analyzed using content analysis approach theory specified persuasive educational communication half total web site content targeted knowledge based information messages concerning outcome expectancies web sites infrequently included messages concerning self regulation furthermore majority web sites accumulated using generic term disability research highlights gaps theory practice emphasizing need better knowledge translation practices
algorithms extracting hydrologic features properties digital elevation models dems challenged large datasets often fit within computer ram depression filling important preconditioning step many algorithms present new linearly scaling algorithm parallelizes priority flood depression filling algorithm subdividing dem tiles using single producer multi consumer design new algorithm works equally well one core multiple cores multiple machines take advantage large memories cope small ones unlike previous algorithms new algorithm guarantees fixed number memory access communication events per subdivision dem comparison testing results new algorithm running generally faster using fewer resources previous algorithms moderately sized tiles algorithm exhibits similar strong weak scaling efficiencies cores linear time scaling across datasets ranging three orders magnitude largest dataset run algorithm trillion cells cores processing required wall time compute days test three orders magnitude larger previously performed literature complete well commented source code correctness tests available download repository elsevier ltd rights reserved
paper describes creation cyberinfrastructure facilitate collaborative materials research laboratory environment supports discovery development sustainment materials processing solutions infrastructure provides web based interface supporting group project spaces within researchers easily organize share collaborate results experimental computational efforts seamlessly connects researchers experimental computational resources easy generation collection storage digital data provide instant access results intermediate transfers persistent identifiers metadata tagging used ensure historical research data discoverable interpretable reusable architecture designed modular agile based federation applications data central service bus brokers transactions comprised number open source commercial non commercial software packages provide specific functionality needed meet large number system requirements collaborative environment essential enabling large research organization conduct research program consistent discipline integrated computational materials engineering allowing seamless connection experiment model pedigreed digital data complete provenance
substantial body research suggests neuropeptide oxytocin promotes social affiliative behaviors wide range animals including humans however antiaggressive action unequivocally demonstrated male laboratory rodents primary goal examine putative serenic effect oxytocin feral strain wild type groningen wtg rats generally show much broader variation higher levels intermale aggression commonly used laboratory strains rats resident animals intracerebroventricularly icv administered different doses synthetic oxytocin oxytocin receptor antagonist alone combination order manipulate brain oxytocin functioning assess behavioral response intruder data clearly demonstrate acute icv administered oxytocin produces dose dependent receptor selective changes social behavior reducing aggression potentiating social exploration antiaggressive effects stronger offensive rats hand administration oxytocin receptor antagonist tends increase nonsignificantly aggression low medium aggressive animals results suggest transiently enhancing brain oxytocin function potent antiaggressive effects whereas attenuation tends enhance aggressiveness addition possible inverse relationship trait aggression endogenous oxytocinergic signaling revealed overall study emphasizes importance brain oxytocinergic signaling regulating intermale offensive aggression study supports suggestion oxytocin receptor agonists could clinically useful curbing heightened aggression seen range neuropsychiatric disorders like antisocial personality disorder autism addiction
quantum gravity effects based generalized uncertainty principle minimal measurable length incorporated black hole physics klein gordon dirac equations get modified using modified equations investigate tunneling scalar particles fermions event acceleration horizons accelerating rotating black holes obtain modified hawking temperature quantum gravity effects see hawking temperature depends black hole parameters well quantum numbers emitted fermions quantum corrections slow black hole evaporation leave black hole remnant contradicts complete evaporation black hole presaged standard temperature formula black holes modified hawking temperatures presented appropriate limits consistent previous results literature
present work investigated biochemical thermo kinetic stability lipases immobilized biocompatible polymeric material immobilization lipase candida rugosa crl carried biocompatible blend poly vinyl alcohol pva chitosan chy support via entrapment glutardehyde glu cross linking method produce pva chy crl pva chy glu crl robust biocatalyst immobilized lipases characterized various physico biochemical characterization techniques later thermal solvent stability polymer immobilized lipase determined term half life time values enthalpy delta degrees entropy delta degrees free energy delta degrees deactivation different temperatures various solvents thermodynamic deactivation stability trend found cross linked lipase crl entrapped lipase crl free lipase crl moreover kinetic parameters max catalytic efficiency also determined understand kinetic features polymer immobilized enzyme reused investigate economic viability developed biocatalyst
objective purpose study examine associations sleep disturbances pregnancy cesarean delivery preterm birth methods prospective study healthy women singleton pregnancy selected three hospitals chengdu china self report questionnaires including sleep quantity quality well exercise habits recent month administered weeks gestation data type delivery gestational age neonates weight recorded delivery controlling potential confounders serial multi factor logistic regression models performed evaluate whether sleep quality quantity associated cesarean delivery preterm birth results women cesarean deliveries delivered preterm women poor sleep quality first second third trimester high risk cesarean delivery women poor sleep quality second third trimester well short sleep time third trimester high risk preterm birth conclusions sleep disturbances associated increased risk cesarean delivery preterm birth throughout pregnancy obstetric care providers advise women childbearing age practice healthy sleep hygiene measures
aim subtotal colectomy stc well established treatment complicated refractory ulcerative colitis laparoscopic approach offers potentially improved outcomes aim study report experience stc single large centre method january may consecutive patients undergoing stc retrospectively analysed prospectively managed database patients known crohn disease undergoing one stage procedures excluded demographics perioperative outcomes second stage procedures analysed results study period stcs performed emergency elective acute severe colitis refractory therapy common indication overall laparoscopic open stcs performed conversion rate mortality morbidity rates respectively whilst operative time shorter open stc min fewer complications shorter hospital stay days following laparoscopic stc fewer complications shorter hospital stay also observed elective stc patients undergoing laparoscopic stc likely undergo restorative second stage procedure open stc conclusion laparoscopic stc feasible safe even emergency situation laparoscopic approach may offer advantages terms lower morbidity reduced length stay elective resection may offer similar advantages best performed whenever possible
lightweight devices smart cards rfid tags limited hardware resource could weak cope asymmetric key cryptography would desirable cryptographic algorithm could optimized order better use hardware resources paper demonstrate identity based encryption algorithms bilinear pairing optimized hardware resources saved notice identity based encryption algorithms bilinear pairing literature must perform elliptic curve group operations multiplicative group operations consume lot hardware resources manage eliminate need multiplicative group operations encryption significant discovery since hardware structure simplified implementing pairing based cryptography experimental results show encryption algorithm saves percent memory ram bits fpga implementation
three factor mutually authenticated key agreement protocols multi server environments gained momentum recent times due advancements wireless technologies associated constraints several authors put forward various authentication protocols multi server environment past decade wang recently proposed biometric based authentication key agreement protocol multi server environment claimed protocol efficient resistant prominent security attacks careful investigation paper shows wang protocol users sharing personal identifiable information application servers registration authentication process nature disclosing credentials leads severe threats particularly insider attacks user impersonation attacks server impersonation attacks remedy aforementioned problems paper proposes novel biometric based mutually authenticated key agreement protocols multi server architecture based elliptic curve cryptography prove proposed protocol achieves secure mutual authentication property using broadly used burrows abadi needham logic formal security proposed protocol verified using widely accepted automated validation internet security protocols applications tool show protocol withstand active passive attacks including replay man middle attacks proposed protocol robust efficient compared existing related protocols
belle experiment start physics data taking superkekb factory search new physics beyond standard model flavor physics channels belle data acquisition daq system consists large number subsystems handle high trigger rate huge data bandwidth subsystem considered network accessible component distributed control network software control monitoring system belle experiment newly developed manage data flow subsystems slow control system handles operations daq subsystems including parameter management relational databases data quality monitor system analyzes event sample online data flow monitor status detector data taking graphical user interfaces also developed software systems report designs slow control dqm system results operation beam test prototypes belle detector components desy test beam facility january
axial spondyloarthritis axspa patients divided structural damage joint visible rays termed radiographic axspa earlier phase disease without structural damage joint termed non radiographic axspa tnf blockers shown highly effective treatment active axspa interestingly conventional dmards also non tnf blocker biologics targeting cells abatacept effective recent interest focused cytokines potential treatment targets axspa open label trial ustekinumab showed good efficacy patients two placebo controlled phase trials mab blocking secukinumab showed good reduction disease activity similar shown tnf blockers probably triggered inflammation new bone formation another hallmark potentially important treatment target however previously reported inhibitory effect nsaid treatment could confirmed recent nsaid trial
associative memories data structures allow retrieval previously stored messages given part content thus behave similarly human brain memory capable instance retrieving end song given beginning among different families associative memories sparse ones known provide best efficiency ratio number bits stored bits used recently new family sparse associative memories achieving almost optimal efficiency proposed structure relying binary connections neurons induces direct mapping input messages stored patterns nevertheless well known nonuniformity stored messages lead dramatic decrease performance paper show impact nonuniformity performance recent model exploit structure model improve performance practical applications data necessarily uniform order approach performance networks uniformly distributed messages presented theoretical studies twin neurons introduced assess adapted model twin neurons used real world data optimize power consumption electronic circuits practical test cases
modified novolac epoxy resins furan pendant groups prepared novolac epoxy resin furfuryl alcohol crosslinked bifunctional maleimide via diels alder chemistry obtain thermally reversible self healing novolac epoxy resins prepared crosslinked novolac epoxy resins characterized nmr tga dma results indicate novel crosslinked novolac epoxy resins present higher storage modulus gpa degrees excellent thermal stability degrees mass loss furthermore thermal reversible self healing properties studied detail dsc sem thermal solution gel solution gel transition experiments results reveal crosslinked novolac epoxy resins based reaction used smart material practical application electronic packaging structural materials wiley periodicals inc appl polym sci
show statistical thermodynamics formulated situations metaequilibrium metastability cases supercooled liquids glasses respectively analogy phenomenological thermodynamics primary quantities considered heat absorbed work performed system interest defined energy exchanges occur system put contact thermostat barostat whole system dealt global hamiltonian dynamical system coefficients fundamental form turn expressions closure form manifest gives first principle step performed making use time reversibility provides new expressions coefficients second principle form clausius also manifest coefficients expressed terms time autocorrelations suitable dynamical variables way analogous fluctuation dissipation theory equilibrium states results independent ergodicity properties global dynamical system
sustainable infrastructure development long identified key enabler socio economic growth poverty reduction societies globally twenty one years young south african democracy economic prospects fragile unemployment statistics high according trading economics gdp growth rate south africa averaged national development plan government responded instituting presidential infrastructure coordinating commission picc direct national growth drive job creation effecting long term infrastructure investment programme commission mandated cabinet coordinate integrate accelerate implementation individual social economic infrastructure plans civil infrastructure development sector increased urbanization compelling governments public sector expand safe reliable public amenities availability real estate construction congested cities challenge within mining infrastructure construction industry safe rapid efficient mine extraction strategies imperative realize increased production business hurdle rates stakeholder expectations asset owners stakeholders obliged consider advanced mechanized underground excavation support technologies order present feasible solutions timeously engineering design procurement construction management epcm perspective tunnelling technology boring applications distinct advantage conventional excavation techniques solutions may enhance commerce transportation expanding infrastructure concentrations national economic activity providing crucial linkages rural areas cities across international borders paper explores contribution mechanized tunnelling technology boring applications applied conjunction digital automation technologies compared conventional methodologies technological expertise combined paradigm shift delivery project objectives promote economic growth aid recovery economic downturn improve social development
background alzheimer disease common type dementia objective paper propose novel method identify differential pathways hippocampus material methods proposed combined method merging existed methods firstly pathways identified four known methods david neagui package pathway based expressed method pathway network approach differential pathways evaluated setting weight thresholds subsequently combined pathways rank based algorithm called method combined method finally common differential pathways across two five methods selected results pathways obtained different methods also different combined method obtained pathways differential pathways included pathways gained four existing methods hence novel method solved problem inconsistent results besides total common pathways identified metabolism immune system cell cycle conclusions proposed novel method combining four existing methods based rank product algorithm identified significant differential pathways based differential pathways might provide insight treatment diagnosis hippocampus
study two aims first investigate efficacy contribution intermittent pneumatic compression pump management lymphedema second evaluate correlation measurement methods study designed controlled clinical trial physical medicine rehabilitation department ataturk university faculty medicine thirty one patients upper extremity lymphedema following mastectomy participated study patients divided two groups complex decongestive physical therapy cdt group group received allocated treatment including skin care manual lymphatic drainage compression bandages compression garments exercises group cdt combined intermittent pneumatic compression pump group groups treated five times week weeks total sessions patients assessed according circumference measurements landmarks limb volume difference dermal thickness ultrasonography usg pain observed significant differencse groups comparing therapy baseline median volume difference group therapy group beginning median volume difference therapy however significant differences observed two groups terms mentioned parameters concluded pneumatic compression pump contribute reduction lymphedema addition gauging dermal thickness using usg may prove useful measurement method evaluation lymphedema
background long term consequences cancer treatments young women especially fertility issues gaining attention survival rates increase breast cancer frequent malignancy women reproductive age aim purpose review describe serum anti mtillerian hormone amh level diagnosis evolution chemotherapy women reproductive age treated breast cancer second impact taxanes amh association amh amenorrhea comparison amh hormonal markers ovarian reserve studied methods systematic pubmed search conducted articles published april related amh women suffering breast cancer using following key words amh mullerian inhibiting substance ovarian reserve ovarian function breast cancer gonadotoxicity ovarian toxicity amenorrhea chemotherapy menopause results amh levels rapidly fall undetectable levels women chemotherapy generally persist low levels women treatment taxanes seem impact negatively ovarian function data ovarian reserve scarce amh predictor occurrence chemotherapy related amenorrhea relevant hormonal marker ovarian reserve conclusion serum amh relevant tool ovarian reserve assessment follow treatment premenopausal women breast cancer large prospective studies necessary determine predictive interest post treatment residual fertility eventually use fertility preservation counseling treatment initiation elsevier ltd rights reserved
changes emotional processing shown following acute administration range monoaminergic antidepressants may represent important common neuropsychological mechanism underpinning therapeutic effects tianeptine agent challenges traditional monoaminergic hypothesis antidepressant action though exact mode action remains controversial healthy volunteers randomised receive single dose tianeptine placebo subsequently completed battery tasks measuring emotional processing including facial expression recognition emotional memory attentional vigilance well working verbal memory tianeptine treated subjects less accurate identifying facial expressions though valence specific tianeptine group also showed reduced positive affective memory reduced attentional vigilance positive stimuli effects emotional categorization non emotional cognition negative biases aspects emotional processing observed following acute tianeptine administration variance positive biases generally seen acute administration conventional antidepressant drugs despite tianeptine putative antidepressant efficacy intriguing finding context lack consensus regarding tianeptine mechanism action however may consistent reported ability acute tianeptine increase uptake serotonin
constructing structures receiving high vertical horizontal force port facilities caissons breakwaters soft ground sea seashore important increase strength ground inhibit excessive settlement recently numerous studies method wrapping outer wall granular piles geotextile geogrid certain level tensile strength since geotextile increases strength granular piles confinement effects confined granular piles advantages conventional sand compaction piles scp terms bearing capacity settlement furthermore method consumes less aggregate compared conventional sand compaction pile scp gravel compaction pile gcp method study proposed determine characteristics mechanical behaviors bearing capacity stress concentration ratio composite ground improved using scps reinforced geotextile geotextile encased sand pile gesp alternative conventional scp method purpose several loading tests conducted artificially sedimented clay grounds reinforced using conventional scps gesps geotextiles three different tensile strengths various replacement ratios based results study bearing capacity soft clay ground reinforced gesps larger soft ground reinforced conventional scps failure mode gesps buckling different bulging scps tensile strength geotextile little effect bearing capacity buckling failure gesps
insulin pump therapy subcutaneous insulin pump therapy csii currently physiological form insulin delivery patients type diabetes benefit improvement hbac levels hba glycohemoglobin type reduced rate hypoglycemia reduced glucose fluctuations thereby improved glucose control reduce risk long term diabetic complications sensor augmented pump therapy csii optimal basis used combination continuous glucose monitoring systems cgm sensor augmented pump therapy sap relevant first step towards soon available closed loop system artificial pancreas
performance magnetic resonance imaging mri equipment typically monitored quality assurance program program includes various tests performed regular intervals users may execute specific tests daily weekly monthly exact interval measurements varies according department policies machine setup usage manufacturer recommendations available resources experience single image acquired first patient day offers low effort effective system check daily check repeated identical imaging parameters phantom setup data used derive various time series scanner performance however daily manual processing quickly become laborious multi scanner environment fully automated image analysis results output positively impact process decreasing reaction time improving repeatability offering novel performance evaluation methods study developed daily mri workflow measure multiple scanner performance parameters minimal manual labor required daily system built around phantom image taken radiographers beginning day image acquired consistent phantom setup standardized imaging parameters recorded parameters processed graphs available everyone involved mri process via web based interface presented automatic mri system provides efficient tool following short long term stability mri scanners
paper considered hybrid power system hps wind turbine generator diesel engine generator deg storage device capacitive energy storage paper presents comparative study frequency power control studied isolated wind diesel hps four different classical controllers pitch control wind turbines speed governor control deg classical controllers considered integral proportional integral integral derivative proportional integral derivative pid controller quasi oppositional harmony search qohs algorithm proposed tuning controller gains comparative dynamic simulation response results indicate better performance may achieved choosing pid controller among considered classical controllers subjected different perturbation stability sensitivity analysis presented paper reveals optimized pid controller gains offered proposed qohs algorithm quite robust need reset wide changes system perturbations elsevier rights reserved
objectives present study designed evaluate attitude toward mouthguard utilization among year old athletically active schoolchildren ludhiana punjab india materials methods cross sectional survey conducted among schoolchildren aged years sexes attending private schools ludhiana punjab india children questioned perceptions regarding protective role mouthguards reasons behind using mouthguards data summarized analyzed using statistical software statistical package social sciences spss version results prevalence mouthguard use found however children believed mouthguards could protect injuries hand majority children using mouthguards said would willing play without mouthguard children using mouthguards reported problems children using dentist made mouthguards reported expensive children wearing boil bite mouthguards reported several problems difficulty speaking interference breathing conclusion deduced usage mouthguards age group inadequate dentists need targeted recommendation properly fitting custom made mouthguards parents susceptible children positive behavior toward mouthguards reinforced
group delay engineered noncommensurate transmission line two port pass network analog signal processing applications presented analytically modeled experimentally demonstrated network consists transversally cascaded sections distributed implementations bridged equalizer lumped circuit obtained interconnecting alternate ports adjacent lines port coupled transmission line network transmission line sections modeled using multiconductor transmission line theory per unit length capacitance matrix inductance matrix allowing different sections network exhibit different lengths generalized group delay engineering procedure proposed quasi arbitrary group delay responses achieved combining group delay responses sections different lengths computer design approach based genetic algorithms applied synthesis consists determining structural parameters different section groups using approach noncommensurate networks group delay engineered edge coupled stripline technology gaussian linear quadratic group delay responses realized theoretical results validated experiment finally two application examples analog signal processing tunable impulse delay line real time frequency discriminator using proposed dispersive noncommensurate pass networks presented
purpose although previous studies demonstrate associations adverse perinatal outcomes developmental disabilities dds study population impacts limited methods computed relative risks adjusted arrs sociodemographic factors component summary population attributable fractions pafs associations low birth weight vlbw preterm births moderately low birth weight mlbw preterm mlbw term normal birth weight nbw preterm seven dds cerebral palsy autism spectrum disorder asd intellectual disability behavioral conduct disorders attention deficit hyperactivity disorder adhd learning disability developmental delay among children aged years national survey children health results vlbw preterm mlbw preterm nbw preterm strongly moderately associated arrs respectively significant also associated asd developmental delay arr ranges vlbw preterm mlbw preterm nbw preterm summary pafs preterm birth lbw asd developmental delay less adhd behavioral conduct disorders findings similar whether assessed dds independent outcomes within mutually exclusive categories accounting occurrence conclusions preterm birth sizable impact child neurodevelopment however relative associations population impacts vary widely type elsevier inc rights reserved
paper extension author already done paper see one solution xor problem using minimum configuration mlp ann model proposed solution proved mathematically paper problem non linear separability addressed paper architectural graph representation proposed model placed also equivalent signal flow graph represented show proof proposed solution non linear activation function used hidden layer minimum configuration mlp logistic function authors published elsevier
investigated implicit attitudes chinese youth towards second generation rich relationship explicit attitudes participants undergraduate students men women using semantic differential measure feeling thermometer scale examined participants explicit attitudes used implicit association test assess implicit attitudes toward second generation rich results showed participants show negative implicit attitude towards second generation rich however participants exhibited negative explicit attitude toward second generation rich results consistent previous research suggests second generation rich take advantage findings project positive image people china
paper development novel controller bidirectional buck boost converter studied implement active capacitance end averaging method used obtain nonlinear state space model converter continuous conduction mode ccm buck boost configurations separately models combined state space representation whole range operation using obtained model controller designed track desired input current based applied input voltage circuit exhibits capacitive effect input terminals converter along proposed control method suitable replacement commonly used electrolytic capacitors different applications simulation results presented demonstrate performance proposed current control method experimental verification currently investigation
cocaine addiction chronic persistent become major social health problem many countries existing studies shown cocaine addicts often undergo episodic periods addiction moderate dependence swearing cocaine given reversible feature cocaine use formulated stochastic process transits one state another impacts various factors treatment received individuals psychological problems cocaine use may vary across states article develops hidden markov latent variable model study multivariate longitudinal data concerning cocaine use california civil addict program proposed model generalizes conventional latent variable models allow bidirectional transition cocaine addiction states conventional hidden markov models allow latent variables dynamic interrelationship develop maximum likelihood approach along monte carlo expectation conditional maximization mcecm algorithm conduct parameter estimation asymptotic properties parameter estimates statistics testing heterogeneity model parameters investigated finite sample performance proposed methodology demonstrated simulation studies application cocaine use study provides insights prevention cocaine use
paper presents novel method analysis nonlinear financial economic systems modeling approach integrates classical concepts state space representation time series regression analytical numerical scheme leads parameter space representation constitutes valid alternative represent dynamical behavior results reveal business cycles clearly revealed noise effects common financial indices elegantly filtered results
aim research determine effects model ensure misconceptions towards scientific ideas effect change persistence simple electrical circuits research carried three different groups grade students mamak cagribey anatolian high school ankara research pre post test control group quasi experimental design applied misconception test consisting three tier questions used data collection tools lesson taught using model based constructivist approach experimental group researcher control group course taught using direct instruction question answer method researcher control group course taught using direct instruction question answer method another physics teacher according findings study shown model significantly contribution conceptual change retention
early prediction success green building projects important challenging issue aim study develop model predict cost schedule performance green building projects based level definition pre project planning phase end three step process proposed pre processing variable selection prediction model construction data certified green buildings used develop models balancing data set respect proportion cases outcome categories pre processing number input variables reduced cost schedule performance prediction respectively using relieff variable selection method cost schedule performance prediction models constructed using selected variables four different classifiers support vector machine svm back propagation neural network bpnn decision tree algorithm logistic regression classification performance four models compared assess applicability svm models exhibited highest accuracy sensitivity specificity predicting cost schedule performance green building projects results study empirically validated cost schedule performance green building projects highly dependent quality definition pre project planning phase elsevier ltd rights reserved
multiple proteases system hydrolyze target substrates recent evidence indicates proteases degrade proteases well cathepsin hydrolysis cathepsin one example interactions may uni directional change expected kinetics explore potential protease protease interactions silico program developed users input two proteases protease ase hydrolyzes substrate protease program identifies putative sites substrate protease highly susceptible cleavage protease ase using sliding window approach scores amino acid sequences preference protease ase active site culled merops database call pacmans protease ase cleavage merops analyzed specificities test validate algorithm cathepsins pacmans cumulative likelihood scoring identified sites cathepsin subject cathepsin hydrolysis mutations made locations tested block hydrolysis validate pacmans predictions cathepsin mutants significantly reduced cathepsin hydrolysis validating pacmans unbiased identification sites interfamilial protease interactions cathepsin mmp mmp tested predictions pacmans confirming utility systems well pacmans unique compared putative site cleavage programs allowing users define proteases interest target also employed non protease substrate proteins well short peptide sequences
objective effective treatment schizophrenia requires continuous antipsychotic maintenance therapy however poor persistence treatment common among patients schizophrenia objective study compare persistence hospitalization rates among patients schizophrenia treated long acting injectable lai antipsychotics paliperidone palmitate risperidone enrolled patient information program program cohort patients treated oral antipsychotics oas enrolled patient information program nonprogram cohort research design methods using quasi experimental design data chart reviews program patients medicaid claims nonprogram patients analyzed patients eligible months pre index data months post index data hospitalization index main outcome measures persistence hospitalization rates assessed months post index propensity score matching used control observed differences demographics baseline clinical characteristics odds ratios ors calculated using generalized estimating equation models adjusted matched pairs propensity score results total program patients matched nonprogram patients similar baseline characteristics adjusted ors indicated persistence rate months significantly higher program cohort versus nonprogram cohort month post index hospitalization rate program cohort significantly lower versus nonprogram cohort adjustments limitations data program nonprogram patients two different independent data sources healthcare claims chart reviews respectively results based relatively small number program lai patients conclusion program patients treated lai antipsychotics higher persistence rates significantly lower adjusted hospitalization rates compared nonprogram patients treated oas
paper proposes lyapunov based model reference adaptive pid controller satellite launch vehicle slv systems slv open loop unstable plant time varying characteristics general handled help gain scheduling controllers improve tracking performance lyapunov based adaptive pid controllers designed model reference adaptive control structure performances compared existing gain scheduling pid controller particular show adaptive pid controller outperforms presence unmodelled dynamics wind disturbance conditions elsevier masson sas rights reserved
background fiveworkers plantmanufacturing concrete wall panels beams referred department suspected occupational dermatitis patch tested workers reacted potassium dichromate four workers reacted ethylenediamine dihydrochloride without obvious exposure owing high proportion workers recent onset skin disease investigation workers plant initiated objectives investigate prevalence occupational dermatitis contact allergy workers plant methods workers plant underwent clinical investigation patch tested results four cases allergic occupational contact dermatitis cases irritant occupational contact dermatitis diagnosed contact allergy potassium dichromate found workers also reacted ethylenediamine dihydrochloride amines present additives cement conclusions chromate contact allergy still found concrete workers despite legislation regulating amount hexavalent chromium chromate cement occupational contact allergy amines found workers exposed cement concrete amines tested workers
paper devoted obtain stabilizing optimal nonlinear controller based well known control lyapunov krasovskii functional clkf approach aimed solve inverse optimality problem class nonlinear time delay systems determine sufficient conditions bellman equation solution system consideration clkf inverse optimality approach considered paper comparison previous results scheme allows obtain less conservative controllers implying energy saving terms average power consumption specific thermoelectrical process sufficient delay independent criteria terms cut obtained closed loop nonlinear time delay system guaranteed local asymptotically stable illustrate effectiveness theoretical results comparative study industrial pid controller tuned ziegler nichols methodology robust pid tuned using partition method presented online experimental tests atmospheric drying process time delay dynamics isa published elsevier ltd rights reserved
insomnia common among elderly people nearly adult population also suffer insomnia pharmacological treatment insomnia include use benzodiazepine non benzodiazepine drugs like zolpidem zaleplon zopiclone although drugs improve sleep usage also associated number adverse effects melatonin hormone secreted pineal gland animals human beings used treatment insomnias since timing secretion humans well animals coincides increase nocturnal sleep propensity short half life melatonin slow release preparations introduced treatment insomnia recently ramelteon selective receptor agonist greater efficacy action treating insomnia used clinically found effective improving sleep quality sleep efficacy also reducing sleep onset time compared melatonin slow melatonin preparations mechanism action ramelteon improving sleep discussed paper another melatonergic drug agomelatine besides acting receptors also displays htc antagonism drug found effective novel antidepressant treating major depressive disorders agomelatine besides causing remission depressive symptoms also improves sleep quality efficiency antidepressants depressants clinical use today improve sleep melatonergic drugs like tasimelteon chloromelatonin ramelteon agomelatine deserve special attention treatment insomnia sleep disturbances associated depressive disorders promising role treatment sleep disorders
dietary fibre represents wide spectrum polysaccharides escape digestion human gastrointestinal tract term widely associated positive health outcomes fibre content food products potential basis nutritional composition claims many parts world current review aims evaluate current evidence human trials impact fibre rich foods isolated dietary fibre body weight management evidence observational studies consistently demonstrates habitual increased intake fruits vegetables whole grains associated lower body weight increase time adherence healthier dietary templates including incorporation higher amounts plant based foods intervention studies also tend evidence greater weight loss control diets highlights importance fruits vegetables whole grains foundation positive dietary habit contrast randomised controlled trials based increase fruit vegetable wholegrain food intake alone tend show impact body weight body fat outcomes suggesting either length previous studies long enough observe measurable effects dietary changes alone benefit outcomes individual intervention studies suggest potential benefits fibre isolates weight loss appears reproducible evidence efficacy glucomannan limited amount available evidence suggests need well designed appropriately targeted intervention studies future elsevier ltd rights reserved
differential cryptanalysis effective tool modern cryptanalysis differential chain markov cipher forms markov chain second largest eigenvalue sle transition matrix determines number iterations markov cipher resist differential cryptanalysis owing huge scale transition matrix infeasible compute sle thus estimation method would desirable find two methods estimate sle using elements row stochastic matrix literature advantage parallel computing without generating complete matrix apply two methods transition matrix international data encryption algorithm investigate accuracy estimation international data encryption algorithm primitive markov cipher transition matrix converge uniform distribution use power initial transition matrix estimate sle different number rounds compare results errors estimation acceptable several rounds less zero elements transition matrix distribution uniform moreover present simple relation sle number iterations markov cipher requires differential cryptanalysis show necessary condition matrix decomposition method copyright john wiley sons ltd
introduction argentina national guidelines lipid control emphasize use relatively inexpensive low moderate potency statins patients high risk cardiovascular event objective study compare impact costs current national cvd prevention guidelines regard morbidity mortality argentina impact costs three strategies incorporate high potency statins used cvd policy model argentina model proposed interventions model national scale state transition markov computer simulation model cvd incidence prevalence mortality costs adults years age modeled three scenarios scenario lowers risk threshold treatment according framingham risk score frs scenario intensifies statin potency current treatment thresholds scenario combines scenarios lowering treatment threshold frs intensifying statin potency scenario would translate fewer mis fewer chd deaths every year reduction respectively scenario would lead fewer mis fewer chd deaths every year scenario would result greatest reduction mis chd deaths fewer mis fewer chd deaths every year translates reduction respectively scenarios cost effective cost high potency statin pill incorporating individuals greater cardiovascular risk use high potency statins argentina national lipid guidelines could result fewer chd deaths events reasonable cost
dimension reduction crucial technique machine learning data mining widely used areas medicine bioinformatics genetics paper propose two stage local dimension reduction approach classification microarray data first stage new regularized feature selection method defined remove irrelevant redundant features select important features biomarkers next stage pls based feature extraction implemented selected features extract synthesis features best reflect discriminating characteristics classification suitability proposal demonstrated empirical study done ten widely used microarray datasets results show effectiveness competitiveness compared four state art methods experimental results jude dataset shows method effectively applied microarray data analysis subtype prediction discovery gene coexpression elsevier ltd rights reserved
prolonged sitting time risk factor cause mortality independent physical activity nurse educators particularly risk due limited physical activity older age increasing use computers descriptive correlational study designed explore nurse educators relation self reported health status general health indicators convenience sample nurse educators recruited participants completed demographic items general health questions workforce sitting questionnaire wsq chau van der ploeg dunn kurko bauman one half participants either overweight obese based body mass index bmi sitting time domains watching non working day leisure activities non working day associated current diagnosis diabetes findings add understanding effects health risks nurse educators
infrastructure sustainability become major global concern massive reservoir siltations seriously disrupted service many reservoirs worldwide dredged siltations difficult stockpile dispose high water content soft nature study explores novel approach using produce controlled low strength materials clsm reinforced geobags used storage backfill applications test results shown initially geobags provided significant contribution strength improvement based clsm however effective reinforcement appears highly dependent upon type geotextile original strength clsm results show promising solution reusing reservoir siltations ensuring sustainable approach mitigation silted reservoir
nowadays complex hybrid systems whose behavior combines continuous discrete event dynamics applied many engineering applications electrical circuits aircraft systems however diagnosis hybrid system composed components involving multiple modes demands unfordable computation due high complexity exponential behaviors caused combinational explosion complexity hybrid system makes online fault diagnosis challenging typical traditional model based approaches hybrid systems make use global monolithic system models online analysis result loss scalability efficiency tackle problem paper proposes possible conflicts based distributed diagnosis method models hybrid system concurrent probabilistic hybrid automation cpha guaranteeing robustness decomposes original system diagnose subsystems concurrently employs focused hybrid estimation fhe estimate likely hybrid states including discrete mode continuous state subsystem conclusion combine cpha fhe distributed diagnosis method accurate timely online fault diagnosis approach state estimation hybrid system finally using method three tank system advantage method verified experimental results
world fastest growing major economy home nearly one fifth worlds population india vibrant democracy midst profound transformation rapid urbanization urbanization improves quality life people promoting economic growth however also increases energy consumption capable generating energy crisis urbanization significant impact carbon dioxide emissions well paper empirically investigates temporal dynamic causal relationships urbanization energy consumption emissions study also aims understand urbanization process india terms level tempo urbanization urban growth morphology utilizing census data rise energy consumption resulting emissions context rapid urbanization also reviewed address problems study recommends series measures set strategies include energy intensity emission intensity reduction measures continuous monitoring information feedback systems introduction industrial energy quota management incentives energy efficient facilities shutting inefficient facilities setting smart residential buildings reduction distribution transmission losses investing smart grids also highly recommended
association sarcoidosis autoimmune comorbidities reported however seldom confirmed large nationwide study study aimed clarify association sarcoidosis autoimmune comorbidities taiwanese total patients sarcoidosis age sex matched control subjects selected national health insurance research database taiwan multiple logistic regressions performed calculate odds comorbidities two groups prevalence sarcoidosis individuals taiwan sarcoidosis patients tended run higher risk autoimmune comorbidities control group autoimmune thyroid disease adjusted odd ratio aor confidence interval sjogren syndrome aor ankylosing spondylitis aor significantly associated sarcoidosis sex stratified analyses carried demonstrate significant association sarcoidosis ankylosing spondylitis sexes autoimmune thyroid disease male patients sjogren syndrome female patients respectively besides diagnosis autoimmune comorbidities strongly associated sarcoidosis tended established sarcoidosis study demonstrated patients sarcoidosis tended autoimmune thyroid disease sjogren syndrome ankylosing spondylitis diagnosis sarcoidosis usually preceded associated comorbidities clinicians alert autoimmune comorbidities patients sarcoidosis
recent large scale genome wide association studies gwas enabled discovery common genetic variations contributing risk architectures schizophrenia human populations however majority gwas identified variants located large genomic regions spanning multiple genes recognizing precise targets mechanisms clinical associations major challenge review recent progress schizophrenia genetics functional genomics related neuroscience research propose functional pipeline translate schizophrenia gwas risk loci disease biology information drug discovery pipeline includes identification underlying molecular mechanisms using transcriptomic data human brain prioritization putative functional causative variants integration genetic epidemiological bioinformatics methods well molecular approaches vitro vivo experimental characterizations identified targeted species causative variants dissect relevant disease biology approaches accelerate progress schizophrenia genetic studies biological mechanisms ultimately guide development prognostic preventive therapeutic measures
development automated morphological classification schemes successfully distinguish morphological types galaxies used studies formation subsequent evolution galaxies universe paper present new automated machine supervised learning astronomical classification scheme based nonnegative matrix factorization algorithm scheme making distinctions types roughly corresponding hubble types elliptical lenticulars spiral irregular galaxies proposed algorithm performed two examples different number image small dataset contains image large dataset contains images experimental results show galaxy images efigi catalog classified automatically accuracy similar small similar large number results good agreement compared visual classifications
aquatic bacteria isolated hands working staffs adapted culture protocol sample solution obtained glove juice method incubated days room temperature viable cell counts increased fold majority isolated colonies shown gram negative aquatic bacteria carry risk contaminating water using medium coagulase negative staphylococci dominant microbes immediately recovery hands revealed bacteria phylum proteobacteria isolated hand causative bacteria aqueous contamination modification method may useful effective training protocol demonstrate importance hand hygiene clean operation aseptic manufacturing
background many infants children receive acetaminophen ibuprofen febrile illness previously studies linked acetaminophen ibuprofen use wheezing exacerbation asthma symptoms infants children objective assess whether acetaminophen ibuprofen use associated wheezing children presenting emergency department febrile illness methods cross sectional study children presented fever pediatric data collected questionnaires children medical files patients wheezing compared nonwheezing patients associations medication use wheezing assessed using univariate multivariate analyses multivariate analysis adjusted potential confounding variables age atopic dermatitis allergies smoking antibiotics use etc via propensity scores results study period children admitted met inclusion criteria included study use acetaminophen similar children diagnosed wheezing compared without wheezing respectively ibuprofen use significantly lower children diagnosed wheezing respectively multivariate analysis acetaminophen associated higher rate wheezing acute febrile illness adjusted odds ratio whereas ibuprofen associated lower risk wheezing adjusted conclusions study suggests acetaminophen ibuprofen associated increased risk wheezing acute febrile illness
purpose aim study investigate risk falls fractures among older adults receiving atypical antipsychotics methods emulation analysis previously published study performed using truven marketscan medicare supplemental database mdcr addition modified analyses implemented evaluate alternative confounding control strategies included covariates used fit propensity score models outcome models required patients mental health condition diagnosis health care visit within days prior index date findings mdcr emulation analyses yielded similar results previous study previous study emulation analysis results nonvertebral osteoporotic fractures odds ratio confidence interval respectively hip fractures respectively fracture respectively falls respectively however modified analyses associations significant primary change resulted attenuation associations requirement patients mental health condition diagnosis health care visit prior index date conclusions mdcr emulation analysis yielded similar results previous study however modified analyses associations fractures falls atypical antipsychotics longer significant contrast results emulation modified analyses may due analytic approach used compare patients potential confounding indication research warranted evaluate associations
objective determine feasibility using physical activity behavior change pabc intervention increasing physical activity reducing disability veterans years following dysvascular lower limb amputation lla design cross feasibility trial setting geriatric research education clinical center veterans homes participants veterans dysvascular lla years major lla intervention home based study using telerehabilitation technology intended reduce participant burden removing transportation time bafflers participants randomized two participation periods three months months pabc intervention occur months group months group pabc intervention participants engage weekly video interaction physical therapist uses collaborative approach develop self monitoring barrier identification problem solving action planning skills improve physical activity group participate physical activity intervention attention control months group contact intervention wash period months main outcome measures feasibility determined using measures participant retention dose goal attainment participant acceptability safety initial effect size effect size based accelerometer based physical activity self report disability using late life function disability index conclusions study focuses prevalent understudied population low physical activity high levels disability due dysvascular lla results study guide future development targeted rehabilitation research improve long term physical activity disability outcomes published elsevier inc
work low voltage current feedback operational amplifier cfoa bulk driven quasi floating gate qfg transistor bulk driven quasi floating gate qfg transistor techniques operate low supply voltage proposed proposed circuits design based voltage follower current follower output stages designed base voltage follower cfoa circuits designed using cmos technology supply voltage operated simulation results shows output impedance cfoa bulk driven quasi floating gate qfg mos transistor bulk driven quasi floating gate qfg mos transistor omega omega omega respectively finally proposed qfg qfg mos transistors techniques used ultra low voltage low power cfoa circuits
fruit yogurt identified individually indicators healthy dietary patterns fruits relatively low energy density excellent source antioxidants prebiotic fibers polyphenols promote digestive health yogurt hand nutrient dense food good source dairy protein calcium magnesium vitamin conjugated linoleic acid key fatty acids addition contains beneficial bacterial cultures making potential source probiotics yogurt unique fermented food matrix provides added health benefits enhancing nutrient absorption digestion combining intake yogurt fruit could provide probiotics prebiotics high quality protein important fatty acids mixture vitamins minerals potential exert synergistic effects health yogurt consumption associated reduced weight gain lower incidence type diabetes whereas fruits established effects reducing risk cardiovascular disease yogurt fruits eaten together may exert combined health benefits potential prebiotic probiotic effects furthermore substituting high energy nutrient deficient snacks fruit yogurt could reduce intake high calorie obesogenic foods light positive cardiometabolic impacts fruit yogurt association healthy dietary patterns sufficient evidence warrant exploration potential synergistic health benefits combined intake fruit yogurt
nowadays majority construction projects considered complex ambiguous endeavours kind construction project characteristics complexities whereas specific management approaches solutions needed regarding rapid development cities underground constructions urban regions metro construction largely used extending daily human life underground spaces therefore recognition complex elements metro construction play significant role management planning aim study investigate complexities subway construction may develop possibility high predictability challenges metro projects also urban underground projects internal external issues studied impacts project management discussed concluded exceptional differences managing planning constructions combined internal external complexities carried simultaneously authors published elsevier
working day weather passive millimeter wave radiometer pmmw widely used civil military affairs get specific information material characteristics different radar infrared detectors basis radiometric operating range equation radiation cross section stealth effect metal objects presented pmmw near sensing application measurement experiments metal solid models adopts band dicke radiometer outdoor calibration system sky temperature different surface metal objects also measured contrastive experiments results show radiometric temperature contrasts solid models remarkable difference bare coated conditions radiometric operating range decrease addition pmmw stealth methods different surface treatment respectively reduce radiometric antenna temperature contrast degree
favourable context women hiv prevent unintended pregnancy cornerstone reproductive rights contribute achieving universal access reproductive health millennium development goal target analysis explores reproductive trajectories mexican women hiv post diagnosis access reproductive counselling use contraceptives depth interviews short surveys conducted women reproductive age living hiv results indicate sexual reproductive health counselling hiv care focuses male condom routinely address reproductive desires provide information access contraceptive methods unintended pregnancies result inconsistent condom use condom breakage women experienced discriminatory denial pressure accept particular contraceptive methods hiv status mexican women hiv enjoying constitutionally guaranteed right freely choose number spacing children mexico commitment reproductive rights popular health insurance offer policy financial frameworks providing family planning services public hiv clinics ensure respectful implementation rights based training hiv healthcare providers careful monitoring evaluation needed
introduction secukinumab cosentyx interleukin inhibitor administered subcutaneously received approval number countries including usa japan treatment plaque psoriasis psoriatic arthritis psa ankylosing spondylitis areas covered review addresses mechanism action efficacy safety secukinumab observed clinical studies patients psa data recent studies secukinumab psoriasis psa included expert commentary secukinumab appears effective improving various aspects psa including improvements psoriatic skin enthesitis dactylitis well inhibition radiographic progression peripheral arthritis secukinumab general well tolerated common adverse events nasopharyngitis headache upper respiratory tract infection
watching contact members one ingroup members outgroup media mediated vicarious contact improves intergroup attitudes compare mediated vicarious contact observing members outgroup parasocial contact examine whether activity portrayed contact matters building theory predict watching outgroup members playing music reduce prejudice watching engaged nonmusical activities particularly vicarious parasocial contact results show vicarious musical contact enhances perceptions synchronization liking honesty ingroup outgroup actors video turn results positive attitudes toward outgroup counter predictions parasocial musical contact results less positive outcomes parasocial nonmusical contact
enterovirus one major etiological agents human hand foot mouth disease hfmd worldwide infection young children people immunodeficiency causes severe symptoms high fatality rates however still approved drugs treat infections based previous report peptide aldehyde anti protease present highly specific hydroxy nitrile derivative inhibited proliferation multiple strains coxsackievirus cva various cells low cytotoxicity hydroxy nitrile covalent warhead conferred high potency selectivity interact cysteine residue active site viral protease also documented resistance mutation pro combination polymerase entry inhibitors produced strong synergistic antiviral effects collectively findings suggest compounds potentially developed drugs treatment hfmd published elsevier
paper reviews elements features affect rental capital values green commercial buildings green related factors affecting rental capital values commercial property previous studies classified physical environment economic factors functional attributes design attributes locational attributes operating expenses energy consumption lease terms occupancy level vacancy rates economics incentives critically reviewing past researches methodologies study proposes idea embedding key features green buildings water energy efficiency site locality construction materials indoor air quality landscape design elements commercial property obsolescence authors published elsevier
ultraviolet spectrophotometry widely applied determination water quality parameters advantagous properties compared chemical method high efficiency easy operation non secondary pollutions nitrate nitrogen one major pollutants waste water standard ultraviolet spectrophotometry used determinate concentration nitrate nitrogen water firstly determinate absorbances wavelength used calibrate former followed plotting standard curve linear equation described lambert beer law linearity superposition absorbances various substance standard ultraviolet spectrophotometry based fitted well anymore increase concentration addition found difficult construct absorption model nitrate solution wavelength experiment overcome disadvantages single wavelength double wavalengths spectrophotometry absorbances wavelength covered absorption peak introduced construction model avoid increase model complexification resulted introduction wavelengths run principal components analysis original absorbances data data dimensions compressed process construct absorbance model using locally weighted linear regression good performance achieved training samples set test samples set using model able deal non linear relation absorbance concentration thus raised upper range limit concentrations nitrate nitrogen hundreds defined standard method meanwhile principle procedure analytical method suitable absorbance model construction solutions
diamond promising material whose excellent physical properties foster use radiation detection applications particular hostile operating environments silicon based detectors behavior limited due high radiation fluence within framework application technology computer aided design tcad simulation tools highly envisaged study optimization predictive analysis sensing devices since novelty using diamond electronics material included library commercial state art tcad software tools work propose development application validation numerical models simulate electrical behavior polycrystalline cvd diamond conceived diamond sensors particle detection model focuses characterization physically based pccvd diamond bandgap taking account deep level defects acting recombination centers trap states definite picture polycrystalline diamond band gap still debated effect main parameters trap densities capture cross sections etc deeply investigated thanks simulated approach charge collection efficiency due beta particle irradiation diamond materials provided different vendors different electrode configurations selected figure merit model validation good agreement measurements simulation findings keeping traps density one fitting parameter assesses suitability tcad modeling approach predictive tool design optimization diamond based radiation detectors
failures power grids proven catastrophic continuous system monitoring essential security reliable operation power grids state space models used estimate states system available measurements malicious user introduce error measurements bad data introduced different points grid resulting unpredictable behavior control algorithms scada systems use state information make decisions bad data detection part state estimation process attacker complete knowledge system access large enough number measurements attacks made undetectable various techniques introduce undetectable attacks discussed literature focus models data history based heuristic algorithm proposed recently detect attack however technique fails data attack model slow ramp propose novel technique based rate change largest singular value data matrix detect even slow attacks system focus models
rainwater harvesting irrigate small scale gardens enhances food self sufficiency overcome rural poverty far rainwater harvesting encouraged namibian national water supply sanitation policy supported financially namibian government study proposes two rainwater harvesting facilities irrigate gardens one collects rain household roofs tank storage second collects rain pond roof pond storage aim paper assess benefits rainwater harvesting based gardening propose policy financing implications namibian government investigate benefits rainwater harvesting literature review cost benefit analysis monitoring project pilot plants comparison existing irrigation drinking water infrastructure results indicate rainwater harvesting offers numerous benefits technological economic environmental social terms facilities positive net present value favourable circumstances however material investment costs pose financing problem recommend government fund rainwater harvesting infrastructure finance privately garden operation maintenance costs integrating aspects national rainwater harvesting policy would create conditions achieve benefits scale rainwater harvesting based gardening namibia
big data shifted computing paradigm data analysis data treated simple texts independent data records many applications data structural patterns modeled graph social media road network traffic smart grid etc however still limited amount work done address velocity problem graph processing work aim develop distributed processing system solving pattern matching queries streaming graphs graphs evolve time upon arrives streaming graph update events achieve goal proposed incremental pattern matching algorithm implemented gps vertex centric distributed graph computing framework also extended gps framework support streaming graph adapted subgraphcentric data model reduce communication overhead system performance evaluation using real wiki trace shows approach achieves similar speedup batch algorithm significantly reduces network memory usage
paper presents development intelligent temperature transducer measure temperature range degrees degrees using negative temperature coefficient ntc thermistor ntc thermistor connected timer circuit convert temperature change frequency timer circuit acts signal conditioning circuit scc ntc thermistor exhibits stable temperature frequency characteristic reasonable error levenberg marquardt training algorithm used multilayer perceptron neural network reduce nonlinearity error scc trained artificial neural network ann improved linearity sensitivity precision scc appreciable range linearity approximately similar sensitivity khz degrees achieved intelligence trained ann embedded microcontroller unit performance developed transducer experimentally studied prototype board
economic problems multiplying due deterioration environmental conditions exhaustion fossil based energy sources today world brings question endeavors towards designing environmentally compatible hospital buildings causes less carbon emissions nature reduces construction management costs buildings considers energy efficiency hospital buildings well covering different functions requirements however operating room units hospital comfort requirements utilized utmost level endeavors providing green criteria energy efficiency remained limited objective study determine studies undertaken compliance green building criteria operating room units complicated design characteristics relation hospital units green design criteria operating rooms line national international studies researched within context study raise efficiency explained using examples
background investigate impact initial antifungal therapeutic strategies prognosis invasive candida infections icis intensive care units icus china methods total patients proven icis china scan study analyzed retrospectively empiric pre emptive targeted therapy adopted based starting criteria including clinical microbiological conventional prediction rules primary outcome hospital mortality secondary endpoints duration days icu duration days hospital global responses clinical microbiological end empirical therapy also assessed results total ici patients received antifungal therapy including initial empirical therapy initial pre emptive therapy initial targeted therapy compared initial empirical antifungal therapy targeted antifungal therapy patients initial pre emptive antifungal therapy significantly less clinical remission higher icu hospital mortality microbiological persistence kaplan meier survival analysis revealed ici patients initial pre emptive antifungal therapy targeted antifungal therapy associated reduced hospital duration compared patients initial empirical antifungal therapy confirmation fungal infection log rank test multivariate regression analysis provided evidence initial empirical antifungal therapy independent predictor decreasing hospital mortality ici patients icu admission ici diagnosis odds ratio confidence interval odds ratio confidence interval conclusions initial therapeutic strategy invasive candidiasis independently associated hospital mortality prompt empirical antifungal therapy could critical decrease early hospital mortality
paper introduces course construction order cultivate students engineering ideal practical ability teachers adjust teaching methods teaching devices according students feedback information project teaching motor help students understand engineering application content stepper motor break barriers courses course information construction constantly improving
non intrusive appliance load monitoring nialm helps identify major energy guzzlers building without introducing extra metering cost motivates users take proper actions energy saving greatly facilitates demand response programs nevertheless nialm large scale appliances still open challenge pursue scalable solution energy monitoring contemporary large scale appliance groups propose distributed metering platform use parallel optimization semi intrusive appliance load monitoring sialm based simple power model sparse switching event recovering sser model established recover appliance states aggregated load data furthermore sufficient conditions unambiguous state recovery multiple appliances presented considering conditions well electrical network topology constraint minimum number meters obtained correctly recover energy consumption individual appliances evaluate performance sialm nialm real world trace data synthetic data results demonstrate help small number meters sialm approach significantly improves accuracy energy disaggregation large scale appliances
symmetrical study important mode operation power system paper presents matlab applications solutions steady state transient problems power systems including power flow studies short circuit analysis stability analysis power system modeled electrical network solved steady state powers generator behaves like power sources mainly methods named gauss seidel newton raphson decouple methods used analyzing conditions output used analyzing short circuit stability analysis
purpose men affected multiple sclerosis often experience neurogenic overactive bladder oab lower urinary tract symptoms erectile dysfunction aim study investigate modifications urinary sexual functions administration daily tadalafil tad methods twenty men enrolled single blind week prospective study men without treatment served controls primary outcomes changes baseline international prostate symptom ipss oab questionnaire oab short form international index erectile function iief scores evaluate influence bladder filling somatic reflexes studied variations reflex evoked electrical stimuli applied tibial nerve popliteal fossa recorded soleus muscle also testosterone estradiol ratio measured treatment results tad group improvement ipss oab iief scores found also increase qmax ratio found concomitant reduction post void residual volume without changes reflex conclusions study demonstrates first time daily tad patients multiple sclerosis improves storage symptoms post void residual volume steroid hormone pattern without urodynamic changes
developed new method efficient numerical simulation colloidal suspensions method designed especially well suited parallel code execution also applied single core programs combines stokesian dynamics method variant widely used barnes hut algorithm order reduce computational costs combination inherent parallelization method make simulations large numbers particles within days possible level accuracy determined user limited truncation used multipole expansion compared original stokesian dynamics method complexity reduced linear complexity dilute suspensions strongly clustered particles number particles case non clustered particles dense suspension complexity depends particle configuration max number used processes max inverted right perpendicularn pinverted left perpendicular respectively elsevier rights reserved
pair programming software development technique introduced part extreme programming pair programming two developers share computer work together developing one piece code test pair programming effects students behavior performance middle eastern society interaction restrictions found devised experiment carried entire academic year consists two semesters experiment targeted two sections per semester advanced computer programming course students one sections worked pairs lab sessions applying pair programming rules techniques section students worked individually norm programming labs video recordings recorded throughout lab sessions studied analyzed addition code samples collected students study effect pair programming students code quality experiment found pair programming potential increase students confidence enjoyment course improved course completion rate addition students pair programming sections showed able individually produce code better quality students traditional section
background rumination predicts depression adults adolescents development rumination linked parenting practices limited research investigated research tended rely self report parenting measures aims investigate relationship female adolescent rumination maternal modelling criticism positivity using observational measure parental behaviour method cross sectional design used daughters aged years mothers dyads completed questionnaire measures rumination affect mothers girls rumination scores upper lower quartile also completed five minute speech sample used measure maternal criticism positivity results mothers low rumination girls made significantly positive comments daughters mothers high ruminators mothers made critical comments self reported rumination correlated mothers daughters suggesting lack support potential role modelling conclusion overall low maternal positivity associated rumination female adolescents evidence maternal rumination criticism associated adolescent rumination results suggest number implications future research including need prospective longitudinal studies using observational parenting measures
paper using compensation technique ultra low power two stage operational transconductance amplifier ota full rail rail input output swing presented proposed configuration consists composite transistors improved bulk driven folded cascode structure feed forward compensation path high speed current mirrors comparison typical proposed input stage structure benefit transconductance enhancement power consumption without adversely affecting noise offset performance presented ota simulated cmos technology simulation results confirm theoretical analyses proposed amplifier exhibits gain enhancement well improvement gain bandwidth compared conventional input stage structure finally amplifier consumes supply voltage makes suitable ultra low power applications
proprotein convertase subtilisin kexin type pcsk monoclonal antibody new therapy reduce low density lipoprotein cholesterol ldl level patients familial hypercholesterolemia pooled analysis aimed estimate efficacy safety pcsk antibody therapy reports randomized controlled trials rcts comparing pcsk antibody placebo retrieved search medline via pubmed embase cochrane library databases clinicaltrials gov clinical trial results november language restriction data abstracted standardized protocol found eight rcts patients pooled analysis compared placebo pcsk antibody therapy remarkably reduced ldl level mean reduction total cholesterol mean reduction lipoprotein mean reduction apolipoprotein mean reduction elevated level high density lipoprotein cholesterol mean change apolipoprotein mean change therapy without pcsk antibodies differ rate adverse events pooled rate heterogeneity serious adverse events pooled rate heterogeneity pcsk antibody may effective safe treatment
background research concerning overprescribing psychotropic medicines nursing homes suggests organizational climate plays significant role use psychotropic medicines organizational climate refers members organization perceive work environment well interactions outsiders objectives study aimed explore key dimensions organizational climate subsequent influence use psychotropic medicines methods semi structured interviews conducted site visiting staff eight nursing homes sydney australia purposive sampling used recruit participants representing broad range health disciplines roles transcripts content coded participants perceptions related work environment descriptions psychotropic medicines use thematic analysis used derive key concepts results three salient dimensions organizational climate linked use psychotropic medicines nursing homes staffing managerial expectations teamwork among visiting site staff inadequate staffing levels perceived influence site staff requests initiation psychotropic medicines cope high workload participants reported managers prioritized non pharmacological management behavioral disturbances led site staff reduced preference psychotropic medicines addition trust open communication among site visiting staff facilitated cessation psychotropic medicines conclusion study illustrates organizational climate important factor influencing use psychotropic medicines furthermore study highlights aspects organizational climate need addressed reduce inappropriate prescribing psychotropic medicines elsevier inc rights reserved
introduction tumor necrosis factor tnf alpha inhibitors widely used treatment inflammatory diseases one side effects tnf inhibitors development psoriatiform eruption also known paradoxical psoriasis case report describe patient side effect treatment adalimumab etanercept case report year old female treated adalimumab every weeks pustulosis palmoplantaris psoriatic arthritis injections patient developed psoriatiform eruption body improved discontinuation adalimumab worsened treatment etanercept twice weekly eventually patient treated topical corticosteroids ustekinumab every months complete remission psoriatiform eruption discussion several case reports reviews published recent years describe patients psoriatiform eruption treatment tnf alpha inhibitors pathogenesis causes psoriatic eruption unclear conclusion describe patient psoriatiform eruption treatment adalimumab etanercept patient discontinue treatment eventually complete response treatment topical corticosteroids treatment ustekinumab
motion segmentation non rigid structure motion two challenging computer vision problems attracted numerous research interests previous works handle two problems separately present general motion segmentation framework paper solving two seemingly different problems unified manner heart general motion segmentation framework model selection mechanism based finding minimal basis subspace representation seeking joint sparse representation data matrix however formulation hard solve convex proxy instead unlike compressive sensing related works convex proxy solution insufficient problem convex relaxation artefacts noise yield multiple subspace representations making identification exact number motion subspaces challenging solve right number subspaces transforming problem facility location problem global cost solve factor graph formulation using max product belief propagation message passing
conditional discriminations established using linear series training structure shown previous study intact unreinforced trials assessing performance presented interspersed among stimulus equivalence test trials experimenter defined correct performance trials seen participants responding accordance stimulus equivalence participants goal current study investigate status previously trained relations time stimulus equivalence tests contexts experiment investigated following many one conditional discrimination training adult participants experimenter defined correct performance probes trained relations observed participants formed stimulus equivalence classes well participants responding accordance stimulus equivalence experiment adult participants received linear series many one one many conditional discrimination training tests stimulus equivalence interspersed training trials subsequently participants experienced three additional tests derived trained performance within month original training continued testing passage time little effect stability learned derived performance participants initially responding accordance stimulus equivalence participants failed form stimulus equivalence classes initial test responded line trained relations displayed varied performance time results experiments indicate lack stimulus equivalence performance commonly caused breakdown trained relations time stimulus equivalence test
background aimed evaluate effect week yoga intervention shoulder spinal actions women breast cancer related arm lymphoedema method randomised controlled pilot trial intervention group completed eight weeks daily yoga sessions control group continued best current care including information compression sleeves skin care risks temperature variations recommended safe use affected arm lumbo pelvic posture range motion rom shoulder spine strength shoulder pectoral major minor serratus anterior taken baseline week week follow outcome assessors blinded allocation results week eight intervention group improvement lumbo pelvic posture indicated reduction pelvic obliquity compared control group mean difference degrees degrees secondary finding strength shoulder abduction significantly increased following yoga intervention affected non affected arm significant group changes rom measures result yoga intervention conclusion pilot study demonstrates participation yoga may provide benefits posture strength women breast cancer related lymphoedema improvements may attributed focus yoga overall postural functional movement patterns trials longer intervention follow methodology warranted
consider parametric estimation driving levy process multivariate continuous time autoregressive moving average mcarma process observed discrete time grid beginning new state space representation develop method recover driving levy process exactly continuous record observed mcarma process use tools numerical analysis theory infinitely divisible distributions extend result allow approximate recovery unit increments driving levy process discrete time observations mcarma process show sampling interval chosen dependent length observation horizon converges zero tends infinity suitable generalized method moments estimator based reconstructed sample unit increments asymptotic distribution one based true increments particular asymptotically normally distributed elsevier inc rights reserved
background stigma major problem schizophrenia effective way reduce provide information literature lacks studies evaluating long term efficacy mass communication aims pilot study assess brief intervention report may long term effects method assessing stigma scores subjects seeing vignette results found social distance restriction patients fell brief intervention also kept lower months conclusion conclude even brief intervention may create persistent impact reducing discrimination
modeling non equilibrium solidification multi component alloys singular importance microstructure control however owing complex systems complex additional constraints still open problem work thermodynamic extremal principle applied solve complex additional constraints self consistently thermodynamics consequently short range solute redistribution long range solute diffusion share mobility integrated naturally solute diffusion equations thus avoiding introduction additional kinetic coefficients interface permeability describe solute redistribution application non equilibrium solidification alloys shows anomalous solute trapping anomalous solute profiles within diffuse interface could occur thus highlighting important effect interaction among component elements interface kinetics current phase field model might preferred simulations simplest form evolution equations also feasibility increase simulation efficiency thin interface limit analysis acta materialia inc published elsevier ltd rights reserved
review article maps specific area divorce research important almost uncited czech sociology family connection divorce gender shows although concept gender implicitly embedded social phenomenon divorce majority empirical research divorce conceptualises gender differences behaviour men women approach useful explaining gender structure causes consequences divorce attention given studies explicitly mention concept gender structural institutional interactional levels reviews literature gender part institutional environment context introduces perspectives changing gender roles factor influencing divorce literature mapping potential divorce change gender order society theoretical perspectives relatively rare divorce literature therefore useful provide czech readers review inspiring conceptualisations put context knowledge divorce czech republic
study design prospective clinical trial thoracolumbar trauma year follow objective analyze clinical radiographic outcomes minimal invasive surgery rational circumferential fracture treatment regard age degenerative changes bone mineral density global sagittal balance summary background data non neurologic fractures anterior column defect treated posterior percutaneous instrumentation selective anterior fusion consolidation instrumentation removed year provide mobility non fused segments methods fifty one patients years operated type fractures visual analog scale vas back pain oswestry disability index odi assessed radiographic measurements sagittal index regional kyphosis kyphosis lordosis pelvic incidence pelvic tilt sacral slope tilt anterior fusion facet joints analyzed computed tomography year results odi accident months years years vas months years sagittal index degrees preoperatively degrees months loss reduction degrees occurred implant removal global sagittal balance remained unchanged ten patients osteopenia osteoporosis worse odi versus greater loss correction degrees versus degrees cages filled cancellous bone fractured vertebra fused regularly spontaneous facet joint fusions observed two patients fracture level type injuries conclusion percutaneous instrumentation selective anterior fusion using autologous bone mesh cages lead high fusion rates provided good long term clinical results younger patients thoracolumbar fractures sagittal alignment maintained instrumentation removal without damaging paravertebral muscles outcomes worse elderly patients presenting osteopenia osteoporosis
due demands economical operations power plants environmental awareness performance control boiler turbine unit great importance paper nonlinear multi input multi output model mimo utility boiler turbine unit considered drum pressure generator electric output drum water level output variables controlled manipulation valves position fuel feed water steam flows state space representation problem two controllers based gain scheduling feedback linearization designed tracking performance system investigated discussed three cases near far far set points according results obtained using feedback linearization approach leads quick time responses bit overshoots comparison gain scheduling method addition feedback linearization strategy input control signals valves position actuated less time less oscillations observed presence arbitrary random uncertainty model parameters controller designed based feedback linearization robust finally according phase portraits problem desired speed tracking process increased dynamic system tends demonstrate chaotic behaviour sharif university technology rights reserved
study introduces power quality state space representation describe continuous disturbances tolerance boundary designed represent integrated disturbance tolerance equipment connected electric power network uncertainty integrated disturbance tolerance described cloud model electromagnetic compatibility incompatibility degree indices proposed reflect severity disturbances affecting equipment influence degree index defined quantify severity impact scope disturbances uncertainty equipment fault state expressed fuzzy membership function subsequently performance assessed according equipment compatibility incompatibility degree disturbances case studies bus distribution system performed analysed results reveal effectiveness reasonableness proposed indices assessing equipment compatibility incompatibility degree disturbances influence disturbances equipment performance
analysis quality investments part decision making implementing rainwater harvesting systems order evaluate whether investments environmental impacts mitigation also attractive point view investors considering discounted cash flow methods net present value best indicator analysis allows deciding best two mutually exclusive projects also presents simple calculation routine easily understood users work aimed presenting decision making analysis tool rainwater harvesting systems based maximization net present value using particles swarm optimization technique decision tool used evaluate quality investments implementing rainwater harvesting system considering building public tax category three scenarios water bill considered current rate structure increases scenarios contemplate two alternatives sewage rate corresponding rainwater use fee results illustrate opportunities investments rainwater harvesting systems
fifa world cup south korea japan local governments south korea left charge several large scale soccer stadiums although governments made significant efforts toward creating profits stadiums proving difficult several administrations cover full operational maintenance conservation costs order overcome problem one governments seogwipo city owns jeju world cup stadium jwcs attempting provide independent renewable electricity generation system operation stadium current study therefore examines potential configurations independent renewable electricity generation system jwcs using homer software simulation results yield three optimal system configurations renewable fraction relatively low values cost energy per kwh examination three possible optimal configurations implications limitations current study presented
research language attitudes shown speech style plays important role social evaluation croatia english words commonly occur everyday communication could affect way perceive people study aims investigate relation english words person perception croatian elementary school students adolescents young adults given one three versions text varying frequency english words questionnaire evaluate personal characteristics author text results showed frequent use english words related higher estimations social attractiveness indicating use english words become important cue person perception elsevier ltd rights reserved
background inflammation fibrosis muscular hypertrophy lead thickened bowel crohn disease forming strictures ultrasound shear wave elastography swe measures bowel wall stiffness contrast enhanced ultrasound ceus uniquely detects bowel wall inflammation aim correlate swe ileal crohn disease vivo ceus peak enhancement pathology grades inflammation fibrosis muscular hypertrophy methods prospective institutional review board approved study consecutive ileal patients crohn disease received ultrasound maximal bowel wall thickness swe ceus performed fifteen patients ileal resection within mean time interval days pathology scores inflammation fibrosis muscular hypertrophy compared swe ceus measurements results mean vivo swe velocity patients without surgery respectively ileal specimens chronic exceeded active inflammatory change inverse relationship ceus peak enhancement fibrosis swe velocity measurements strictured bowel specimens smooth muscle hypertrophy fibrosis conclusions stiffer bowel smooth muscle hypertrophy increases swe measurements report novel relation high swe muscle hypertrophy inverse relationship ceus peak enhancement providing differentiation active chronic bowel wall inflammation improve selection medical therapy surgery
propose novel multiple instance learning mil method assess visibility visible visible retinal nerve fiber layer rnfl fundus camera images using image level labels approach learns classify images well localize rnfl visible regions transform original feature space discriminative subspace learn region level classifier subspace propose margin based loss function jointly learn subspace region level classifier experiments rnfl data set containing images annotated two ophthalmologists give system annotator agreement kappa values respectively interannotator agreement system agrees better experienced annotator comparative tests three public data sets messidor diabetic retinopathy ucsb breast cancer show novel mil approach improves performance state art matlab code publicly available https github com manishiyam sub categoryclassifiers multiple instance learning wiki
objective objective determine whether score edinburgh postnatal depression scale epds initial prenatal visit associated increased use acute medical visits compared pregnant women initial epds score methods retrospective cohort study comparing utilization acute medical care pregnancy first eight weeks delivery amongst women epds score initial prenatal visit compared women epds score super utilization defined acute unscheduled medical visits pregnancy first eight weeks delivery percentile logistic regression used control confounders results women initial epds score significantly likely engage super utilization acute medical care compared women scoring adjusted odds ratio aor confidence interval conclusions pregnant women scoring epds initial prenatal visit likely super utilize acute medical care perinatal period subset patients risk increased utilization identified early prenatal care interventions better meet medical psychosocial needs women warrant future research
reaction wheel popular actuator attitude control system acs satellites significant role performing satellite missions reaction wheel supplies torque momentum required satellite attitude control model used acs simulations fdi algorithms accurate model hand physical module special role reaction wheel modeling regard based elements internal structure actuator precise model presented furthermore proposed model general used types moreover paper proposed new model reaction wheel acs simulation proposed model validated real time hil test bed form set point commands profile command
background understanding motivation change key issue assessment treatment eating disorders therefore sound instruments assessing construct great help clinicians accordingly present study analysed psychometric properties anorexia nervosa stages change questionnaire ansocq including relation coping style self esteem methods adolescents referred eating disorders outpatient clinic meeting criteria anorexia nervosa gave written informed consent participate study completed ansocq eating disorder inventory eating attitudes test body image questionnaire two questionnaires measuring self related cognitions coping across situations questionnaire treatment period nine months clinical anorexia nervosa diagnosis body mass index assessed addition exploratory factor analysis correlational analysis used test convergent validity ansocq logistic regression analysis used test predictive validity results ansocq good psychometric properties factor analysis yielded two meaningful factors labelled weight gain control attitudes feelings internal consistencies two factors amounted tocronbach alpha respectively significant correlations scales measuring eating disorder psychopathology indicative meaningful construct validity higher motivation change related higher self esteem active coping style higher positive ansocq total scores predicted remission anorexia nervosa nine months treatment higher score attitudes feelings protective factor drop intervention conclusions ansocq clinically useful instrument measuring motivation change adolescents two factorial dimensions explain variation self esteem coping style relevant additional constructs understanding motivation change anorexia nervosa
relational databases applications opportunities evaluating stream knn queries submitted one one different times issue propose new method learning based techniques region clustering methods caching mechanisms method uses knowledge base store related information past knn queries groups search regions past queries larger regions retrieves tuples larger regions answer newly submitted query strategy tries obtain majority results previously retrieved tuples cached main memory thus method seeks minimize response time reducing search region avoiding accesses underlying database meanwhile method remains effective high dimensional data extensive experiments carried measure performance new strategy results indicate significantly better state art naive methods evaluating stream knn queries low dimensional high dimensional data
posit modern airplane social microcosm class based society increasing incidence air rage understood lens inequality research inequality typically examines effects relatively fixed macrostructural forms inequality socioeconomic status examine temporary exposure physical situational inequality induced design environments foster antisocial behavior use complete set onboard air rage incidents several years large international airline test predictions physical inequality airplanes presence first class cabin associated frequent air rage incidents economy class situational inequality boarding front requiring walking first class cabin versus middle plane also significantly increases odds air rage economy first class show physical design highlights inequality trigger antisocial behavior airplanes broadly results point importance considering design environments airplanes office layouts stadium seating understanding form emergence antisocial behavior
neuromorphic systems used variety circumstances parts sensory systems modeling parts neural systems analog signal processing sensory processing domain neuromorphic systems considered three parts pre transduction processing transduction post transduction processing neuromorphic systems include transducers light odors touch far neuromorphic applications sound domain used standard microphones transduction discuss case describe research done neuromorphic approaches transduction make case change direction toward systems sound transduction neuromorphic component
work presents procedure design analysis linear tubular switched reluctance generator wave energy conversion generator meant applied direct drive wave energy converter namely point absorber device modeled according wave climate conditions esposende site portuguese coast procedure starts statistical analysis local random ocean behavior order determine likely values occurrence wave parameters question based generator analytically designed proper dimensions calculated numerical simulation performed magnetic flux path density values determined
objective study evaluate helper regulatory treg cell profile anca positive granulomatosis polyangiitis gpa relation disease activity prospective study studied two groups gpa patients disease flare active gpa bvas sustained remission year prior enrollment inactive gpa bvas age sex matched healthy subjects served controls active gpa patients followed months reevaluated remission early remission analyzed subsets cells flow cytometry production signature cytokines vitro stimulated lymphocytes broad spectrum serum cytokines luminex gpa patients observed expansion effector cells increased production vitro stimulated cells compared controls disease flare characterized marked reduction treg cells whereas sustained remission showed expansion treg subset finally analyzing cytokine profile identified ccl light potential biomarkers active disease conclude gpa expansion treg lymphocytes parallel increased response characteristic feature sustained remission contrast treg cells markedly decreased disease flare
paper argues research field artificial intelligence education aied benefit integrating recent technological advances wearable devices big data processing modelling printing ambient intelligence design methodologies tormes developing systems address psychomotor learning domain particular acquisition motor skills could benefit individualized instruction support cognitive skills learning last decades point procedural learning considered since earliest days aied dating back however aied developments motor skills learning lagged significantly behind technology evolved supported quantified self movements possible integrate emerging interactive technologies order provide personal awareness reflection behavioural change low cost low intrusion many activities exist would benefit personalizing motor skills learning playing musical instrument handwriting drawing training surgery improving technique sports martial arts learning sign language dancing etc context suggestions aied research coming years focus addressing challenges regarding modelling psychomotor interaction providing appropriate personalized psychomotor support
importance cocaine amphetamine regulated transcript cart peptide reinforcing effects addictive drugs specially alcohol psychostimulants stablished involvement cart peptide rewarding effects opioids brain recently reported studied expression cart mrna peptide reward pathway morphine induced sensitization phenomenon also evaluated peptide level fluctuations csf plasma male wistar rats received day morphine injection day washout period challenge dose morphine administered locomotor activity oral stereotypical behaviors recorded besides expression level cart mrna peptide four important areas mesocorticolimbic reward pathway including nucleus accumbens striatum prefrontal cortex hippocampus measured real time pcr western blotting respectively level peptide csf plasma measured elisa method expression level cart mrna protein brain regions also peptide level csf plasma significantly regulated day morphine administration reduced levels returned nearly normal rates day wash period administration morphine challenge dose led significant upregulation cart gene expression mrna peptide brain elevation peptide level csf plasma morphine sensitized rats concluded cart released framework reward pathway may serve important neurotransmitter process morphine dependence sensitization
long span suspension bridges evolved years bridge girder decks improved well changing shapes standard box deck girders twin box multi box decks sections aerodynamic characteristics new generation twin multiple decks investigated nowadays provide best design wind speeds optimum dimensions bridges could achieve multi box megane bridge deck one new generation bridge decks consisting two side decks traffic lanes two middle decks railways linked connecting beams three dimensional cfd simulations performed employing large eddy simulation les algorithm standard smagorinsky subgrid scale model angles attack alpha degrees degrees degrees degrees degrees also wind tunnel experiment performed scaled model megane bridge deck section aerodynamic static coefficients found good agreement results obtained cfd les model however aerodynamic coefficients determined individually cfd les model traffic railway decks megane bridge varied significantly especially downstream traffic deck also pressure distribution effect spacing connecting beams wind speed profiles showed slight increase turbulence downstream traffic railway decks
rapidly acting antidepressant properties ketamine trend topic psychiatry despite robust effects ephemeral lead certain adverse events reason still general concern around label use ketamine clinical practice settings nonetheless refractory depression indication consider report case female patient admitted several months due treatment resistant depressive bipolar episode chronic suicidal behaviour repeated intravenous ketamine infusions without remarkable side effects patient experienced complete clinical recovery weeks following hospital discharge unfortunately depressive symptoms reappeared week patient finally readmitted hospital result suicide attempt
paper examines task force votes central development diagnostic statistical manual mental disorders dsm iii dsm iii data obtained literature review investigation dsm archival material housed american psychiatric association apa interviews key task force members dsm iii dsm iii data indicate task force votes played central role making dsm iii establishing diagnostic criteria diagnostic definitions settling questions inclusion removal diagnostic categories paper concludes apa represented dsm iii return descriptive psychiatry inaugurated triumph empirically based decision making evidence presented fails support view since dsm cumulative project dsm iii lives subsequent editions paper calls socio historically informed understanding dsm construction deployed dsm taught implemented training clinical settings
sleep characteristics military veterans active duty service members ptsd without ptsd recent wars analyzed determine combat deployment associated sleep restriction may alternative explanation sleep complaints found among combat veterans ptsd determined ptsd checklist military version scores week period sleep data collected using sleep actigraphy self report across entire sample subjective objective assessment methods sleep strongly correlated although notable within group differences specifically although sleep duration groups differ based actigraphy veterans without ptsd reported sleeping min longer veterans ptsd effort determine individuals without ptsd might overreporting sleep found symptoms emotional arousal anger anxiety nightmares significantly correlated self reported sleep duration suggesting pattern higher autonomic arousal found veterans ptsd thus although sleeping higher levels emotional arousal reported veterans ptsd may mean perceive sleep restful research necessary determine sleep architecture veterans ptsd actually different combat veterans without ptsd differences actually amenable standard behavioral treatments disorder
purpose study performed evaluate topical diclofenac menthol gel treating ankle sprain design randomized double blind placebo controlled trial adolescents adults acute ankle sprain applied gel containing diclofenac menthol diclofenac menthol placebo four times daily primary outcome area curve pain intensity movement pain extreme pain hours post application auc days secondary outcomes included pain relief time onset meaningful cooling complete recovery difference sum difference total reduction ankle swelling patient global assessment response treatment results statistically significant differences auc diclofenac menthol placebo diclofenac menthol gels meaningful advantages diclofenac menthol secondary outcome higher incidence skin application site events diclofenac menthol placebo diclofenac conclusion significant improvement observed topical diclofenac menthol gel compared placebo diclofenac menthol gel treating pain ankle sprain clinicaltrials gov identifier nct
mineral prospectivity mapping classification process given study area specific region classified either prospective non prospective area cost false negative errors differs cost false positive errors false positive errors lead wasting much financial material resources whereas false negative errors result loss mineral deposits traditional machine learning algorithms using mapping mineral prospectivity aimed minimize classification errors ignore cost sensitive effects study effects misclassification costs mapping mineral prospectivity explored cost sensitive neural network csnn minimizing misclassification costs applied map polymetallic prospectivity china southwestern fujian metalorganic belt sfmb csnn different cost ratio ranging used represent various misclassification costs cross validation results indicated lower misclassification cost compared traditional neural networks threshold moving based csnn csnn predictive results compared traditional neural network results demonstrate csnn method useful mapping mineral prospectivity targets used explore undiscovered deposits study area elsevier rights reserved
paper presents new realization first order transadmittance mode tam pass filter apf proposed mixed mode apf simple transconductor inverting voltage buffer unity gain current follower used active building blocks considering input intrinsic resistance current follower useful active filter parameter proposed tam apf employs floating capacitor external passive component hence resistorless circuit addition due high impendence voltage input high impedance output current terminal fully cascadable filter realization spice simulation results included support theory design ptm level cmos process bsimv parameters low voltages used
quadtrees well known data structure representing geometric data plane naturally generalize higher dimensions basic operation expand tree splitting given leaf quadtree smooth two adjacent leaf boxes differ one depth paper analyze quadtrees restore smoothness split operation also maintain neighbor pointers main result shows smooth split operation amortized cost auxiliary split operations corresponds amortized constant time quadtrees fixed dimension also show exponential dependence dimension unavoidable via lower bound construction additionally give lower bound construction showing amortized cost omega log splits related quadtree model maintain smoothness elsevier rights reserved
demonstrate comprehensive electrical network mechanical property polymer nanocomposite pnc coherently related specific dispersion nanoparticles controlled grafting like unlike polymer chains pnc graft chain chemistry matrix graft chains relatively short grafted nanoparticle containing chains unit area result loose continuous percolating cluster optimized electrical mechanical utilities achieved low grafting density chains unit area optimized characteristics fulfilled extending graft chain length ratio graft chain length matrix chain length graft chain different chemical structure optimum performance pnc emerges low grafting density matrix graft interaction times matrix matrix interaction ratio elsevier ltd rights reserved
acquired angioedema aae due inhibitor cinh deficiency rare treatment options acute attacks variable used label successful treatment associated lymphoma rituximab seems prevent acute attacks subjects aae aim study describe aae manifestations associated diseases patients responses treatments representative cohort retrospective nationwide study conducted france inclusion criteria recurrent angioedema attacks acquired decrease functional cinh reference value total cases included median age onset years facial edema abdominal pain frequent symptoms fifteen patients hospitalized intensive care unit laryngeal edema patient died anti cinh antibodies present patients associated diseases primarily non hodgkin lymphoma splenic marginal zone lymphomas monoclonal gammopathy undetermined significance three patients myeloma amyloid light chain immunoglobulin amyloidosis patient bronchial adenocarcinoma patients associated disease icatibant relieved symptoms treated patients plasma derived cinh concentrate treated patients six patients experienced thromboembolic events tranexamic acid prophylaxis rituximab prevented angioedema patients monotherapy association chemotherapy splenectomy controlled aae patients treated splenic marginal zone lymphoma median follow years angioedema remission patients aae cases primarily associated indolent lymphoma especially splenic marginal zone lymphoma monoclonal gammopathy undetermined significance autoimmune diseases conditions icatibant plasma derived cinh concentrate control attacks splenectomy immunochemotherapy prevent angioedema lymphoma setting
gender specific personality profiles association level aggressive antisocial behavior offenders previously investigated present study analyzed data collected male female offenders using structured protocols regarding criminal history criminal register data trait aggression life history aggression lha questionnaire personality profiles temperament character inventory tci prison inmates differed significantly several personality dimensions pronouncedly characterized low character maturity low scores selfdirectedness cooperativeness dimensions tci compared gender age matched controls general population majority offenders scored distinctively high trait aggression moderate strong associations personality dimensions subscales lha aggression self directed aggression antisocial behavior associations stronger female offender sample trait aggression could best explained model included male gender younger age high novelty seeking temperament low character maturity results suggest therapies aiming strengthening self governance increasing cooperativeness focusing character maturity may alleviate aggressive antisocial behavior offenders
discursive use language legal contexts multifaceted complex first begins chain oral narrative structures victim witness suspect accounts written texts confessions notes depositions letters internet documents email tweets telephone records used court law transcription oral communiques potentially transformative phase evidence production may flawed ambiguity error mistakes gaps misrepresentation second includes excludes textual narrative representation nonverbal communication kinesics paralanguage proxemics recorded transcripts graphics video enactments stage legal process interpretation narrative structures texts plays key role ultimate meaning verbal nonverbal communication third concerns interrogation strategies tactics preliminary evidence gathering well courtroom fourth involves translation documents written another language interpretation oral statements another language language courtroom
background cancer cachexia skeletal muscle wasting related poor survival study quantitative body composition measurements using computed tomography investigated relation survival post operative complications surgical site infections surgical patients cancer head pancreas methods prospective cohort patients cancer head pancreas analysed imaging level determine muscle radiation attenuation average hounsfield units total skeletal muscle visceral adipose tissue area iii subcutaneous adipose tissue area intermuscular adipose tissue area skeletal muscle area sex specific cut offs determined lower tertile muscle radiation attenuation skeletal muscle area higher tertile adipose tissues variables body composition related overall survival severe post operative complications dindo clavien surgical site infections wounds inspected daily independent trial nurse using cox regression analysis multivariable logistic regression analysis respectively results low muscle radiation attenuation associated shorter survival comparison moderate high muscle radiation attenuation median survival months respectively patient subgroups high muscle radiation attenuation combined either low visceral adipose tissue age years longer survival subgroups respectively muscle radiation attenuation inversely correlated intermuscular adipose tissue high visceral adipose tissue associated increased surgical site infection rate conclusions low muscle radiation attenuation associated reduced survival high visceral adiposity associated increase surgical site infections strong correlation muscle radiation attenuation intermuscular adipose tissue suggests presence ectopic fat muscle warranting investigation image analysis could implemented pre operative risk assessment assist treatment decision making
energy storage systems esss generally planned based active power reactive power another important aspect esss adequately addressed discussed moreover esss often managed individually coordinated planning esss distributed generators dgs may result suitable outcomes order address issues coordinated ess planning presented paper proposed planning place capacity esss dgs determined time active reactive powers included planning esss dgs words optimal active reactive capacities denoted esss dgs network proposed coordinated ess planning carried radial distribution network deregulated electricity market objective function proposed planning maximize profit distribution company disco subject secure operation network planning expressed nonlinear mixed integer optimization problem solved advanced pso strong meta heuristic optimization technique simulation results demonstrate great impacts proposed planning network results demonstrate priority proposed coordinated ess planning compared individual ess planning additionally verified considering reactive power dgs esss changes results planning provides realistic reasonable outputs proposed planning significantly increases disco profit guarantees safe operation network satisfying several security constraints
influence constant speed wind turbine electrical network torque impact lead various problems disturbances affect active power quality reactive power phase phase voltage paper propose original system control solve firstly problems due brutal impact active power secondly control reactive power principle proposed wind energy system statcom supercapacitors energy storage limit rapid variation active power give required reactive power compensation induction machine torque change supercapacitor directly coupled common link whole bidirectional converter control strategy statcom use linear matrix inequalities lmis technic regulate currents injected absorbed inverter strategy used control variable supercapacitor voltage simulation results statcom using state feedback integral controller currents converter simple proportional controller cascaded axis current loop voltage source presented discussed
water flow window consists two glass panes making chamber water layer flows controlled way windows may considered building integrated solar thermal bist collectors could assist incorporate renewable energy systems buildings improving energy efficiency especially properly managed control system despite need automatic controller kind window advantages microprocessor based control solar systems differential controllers described novel controller based inexpensive open source microcontroller board designed built programmed installed experimental prototype water flow window proposed data acquisition control system code sequence steps model algorithm comparison data collected system commercial datalogger presented advantages using open source board proposed control system analysed benefits using control system based microcontroller discussed elsevier ltd rights reserved
hereditary angioedema hae rare potentially life threatening autosomal dominant disease characterized recurrent episodes cutaneous mucosal oedema results reduced expression loss function esterase inhibitors inh opposed common histamine mediated angioedema hae respond well conventional treatments anti histamines steroids adrenaline early recognition timely intervention correct treatment crucial particularly preventing airway obstruction new disease specific treatment including plasma derived recombinant inh ecallantide icatibant recently emerged appropriate use reduce hae associated mortality morbidity however due costs disease specific treatments yet reach malaysia despite randomized clinical trial ffp performed efficacy treating acute attacks hae demonstrated case studies case report illustrates successful treatment acute hae episode ffp malaysian government hospital setting
degradation lmj operational amplifier gamma irradiation studied different dose rates temperatures irradiation results show degradation studied devices due total ionizing dose effects continues increase significantly dose rate decreases rad typical bipolar devices complicate use criteria enhanced low dose rate sensitivity eldrs defined existing standards radiation tests paper shows take account effects radiation testing considering eldrs
switched current based beamformer suitable low power low area applications presented important feature proposed beamformer current consumption increase linearly memory size achieved employing external capacitors memory storage unlike conventional memory fully differential design implemented using delay sum approach analog ram aram used implement delay memory cell aram implemented using circuits memory cells aram consuming cell signal noise ratio snr measured summation channels total current consumption beamformer including bias digital control area elsevier ltd rights reserved
approaches salient object detection focused two dimensional images rare attention attached light field provide exclusive visual information salient object detection computer vision applications effective algorithm salient object detection proposed light field data first boundary connectivity calculated focus image background probability based boundary connectivity achieved computing geodesic distance second authors rank similarity superpixels focus image depth map via graph based manifold ranking carry two initial saliency maps third weighted background probability two initial saliency maps fused produce final saliency results integrated objectness cue authors also exploit integrate effectively objectness visual features compare two fusion strategies linear fusion bayesian integration experiments show light field features helpful saliency detection bayesian integration framework better choice linear fusion method meanwhile way combine multiple features crucial proposed algorithm handles challenging natural scenarios cluttered background similar foreground background produces visual favourable results comparison eight state art methods
historical examples demographic change china italy nigeria utah easter island elsewhere together simple mathematics biological principles show stabilizing world population limited food supply difficult generally appreciated united nations population projections wrong assume spite absence necessary feedbacks nations converge rapidly replacement level fertility thereafter remain level education women provision contraceptives caused dramatic reductions fertility many groups including well educated maintain high fertility small groups persistent high fertility grow supplant low fertility groups resulting continued growth total population global average fertility rate could rise even country fertility rate falling low fertility european countries deaths exceed births population continues grow immigration producing two offspring normal animal species stable populations populations limited resources predation rather birth control may therefore appropriate view growth human population result excess fertility rather excess food
inductive power transfer ipt systems facilitate contactless power transfer two sides across air gap weak magnetic coupling however ipt systems constitute high order resonant circuit difficult design control aiming control problems bidirectional ipt system neural networks based proportional integral derivative pid control strategy proposed paper proposed neural pid method pid gains treated gaussian potential function networks gpfn weights adjusted using online learning algorithm manner neural pid controller flexibility capability conventional pid controller fixed gains convergence gpfn weights learning guaranteed using lyapunov method simulations used test effective performance proposed controller
combustion efficiency combustion stability micro space key constraints scale structure miniature internal combustion engines small scale meso scale glow ignition combustion mode miniature internal combustion engines enhancing glow intensity platinum wire additional electrical heating get better combustion characteristics proposed experimental platform combustion test set glow ignition combustion characteristics miniature internal combustion engine displacement diagnosed indicated improvement cylinder combustion characteristics due enhancing glow intensity obvious normal combustion condition instead increasing glow intensity cyclic variations well misfiring phenomenon tendency deterioration however severe partial burning misfiring conditions enhancing glow intensity remarkably decrease high rate misfiring get better combustion stability broaden limiting combustion regime showing real effect least partly advance starting time combustion shorten combustion duration electrical heating glow ignition combustion considered one underlying approaches extend limit combustion stability prospective meso scale internal combustion engines elsevier ltd rights reserved
paper presents development indicial functions ifs two dimensional bridge deck sections new set ifs predicted cross section great belt bridge gbb discussed two approaches based time frequency domain descriptions applied time domain ifs determined imposing instantaneous change system state variable angle attack aoa air flow bridge section frequency domain indicial representation derived aeroelastic flutter derivatives typically used define self excited harmonic forces eigenvalue problem generated imposing sinusoidal motion bridge section performing sweep frequency range oscillations section ifs thus evaluated exploiting reciprocal relations exist aerodynamic derivatives determine aerodynamic response bridge cross section due step change aoa calculate flutter derivatives sinusoidal oscillations meshless discrete vortex method implemented dvmflow adopted results proposed work applied development reduced order models rom aerodynamic loads suitable investigate fluid structure interaction fsi problems associated practical analysis wind effects long span bridges including phenomena flutter vortex induced vibration buffeting galloping ifs reported paper illustrate importance flow separation vortex shedding dependence magnitude change state variable particular aoa cases reported herein elsevier ltd rights reserved
paper proposes hierarchical digital signal processor dsp code generator virgo large scale general signal processing algorithms hierarchical structured vectorized signal flow graph sfg description used input specifications dsp independent optimization procedure program size execution time performed module hierarchically regard operation order memory assignment register allocation efficient code generation demonstrated comparing instruction steps dynamic steps practical adpcm encoder decoder conventional method
background objectiveinflammation common feature peripheral arterial disease pad periodontal disease aim study evaluate relationship pad periodontal disease examining levels inflammatory cytokines pentraxin interleukin high sensitive reactive protein gingival crevicular fluid serum material methodsa total patients included cross sectional study patients divided two groups based ankle brachial index values pad test group non pad control group demographic evaluations clinical periodontal examinations biochemical analysis pentraxin interleukin high sensitive reactive protein performed compare two groups resultsthere significant differences respect gender age body mass index smoking history duration amount two groups significant differences two groups terms clinical periodontal parameters neither gingival crevicular fluid serum levels cytokines showed differences two groups logistic regression analysis revealed adjusting confounding factors age gender diabetes hypertension body mass index periodontitis raised odds ratio pad confidence interval conclusionalthough significant differences respect clinical periodontal parameters biochemical analyses study group control periodontitis raise odds ratio pad clarify possible relationship future prospective studies needed
bodily knowledge attracted significant attention within humanities related fields last two decades although theoretical discussion bodily knowledge context physical education active past years discussions lack clear conceptual analyses bodily knowledge using phenomenological approach purpose paper clarify notion bodily knowledge furthering epistemological discussions topic within reflective embodied practices instead seeing bodily knowledge inherently connected acquisition motor skills improving physical fitness discuss physical training reflective embodied process turn sensuous information moving body knowledge using outdoor running example describe process forming bodily knowledge includes exploring identifying movement qualities developing capabilities registering changes body directing modifying one training processes based bodily findings contextualizing epistemological discussion adults recreational physical activity paper argues bodily knowledge cultivate individuals trust body awareness embodied responses take responsibility physical exercise biomedical knowledge body sport sciences tends shrink body physiological attributes muscle mass fat percentage analysis stresses agency lived body source knowledge physical activity
autoantibodies igg subclass pathogenic number autoimmune disorders systemic lupus erythomatosus presence circulating ige autoantibodies autoimmune patients also known almost years despite role allergies ige autoantibodies associated higher rate atopy patients however recently recognized active drivers autoimmunity mechanisms involving secretion type interferons plasmacytoid dendritic cells pdc recruitment basophils lymph nodes activation adaptive immune responses cells review formation prevalence affinity roles ige autoantibodies described autoimmunity also present novel evidence supporting triggering ige receptors pdc induces associated phagocytosis cellular process also known lap associated interferon responses activation pdc immune complexes formed dna specific ige antibodies also induce potent cell differentiation plasma cell formation define ige role autoimmune humoral responses
background purpose modifiable risk factor cigarette smoking associated increased risk developing multiple sclerosis disease activity relapsing remitting however less known effect smoking disease progression progressive association cigarette smoking disability accumulation primary progressive ppms investigated methods kaplan meier survival analyses cox proportional hazard modelling used investigate influence cigarette smoking risk reaching expanded disability status scale edss well time edss patients ppms results patients ppms available smoking history identified median time edss years ever smokers years never smokers years edss ever smokers never smokers smokers increased risk faster progression edss edss age disease onset strongest risk factor progression edss edss conclusions investigation large well characterized population based ppms cohort suggests cigarette smoking influence disability accumulation ppms findings support idea ppms driven different underlying pathomechanisms relapsing remitting
background ground level ozone potent airway irritant determinant respiratory morbidity susceptibility health effects ambient ozone may influenced intrinsic extrinsic factors neighborhood socioeconomic status ses questions remain regarding manner extent factors ses influence ozone related health effects particularly across different study areas methods using stage modeling approach evaluated neighborhood ses modifier ozone related pediatric respiratory morbidity atlanta dallas louis acquired multi year data emergency department visits among year olds primary diagnosis respiratory disease city daily concentrations maximum ambient ozone estimated zip code tabulation areas zcta city fusing observed concentration data available network monitors simulations emissions based chemical transport model first stage used conditional logistic regression estimate zcta specific odds ratios ozone respiratory visits controlling temporal trends meteorology second stage combined zcta level estimates bayesian hierarchical model assess overall associations effect modification neighborhood ses considering categorical continuous ses indicators zcta specific levels poverty estimated ors posterior intervals ppb increase ozone results hierarchical model combined effect estimates zctas atlanta zctas dallas zctas louis strongest overall association ozone pediatric respiratory disease atlanta followed dallas louis patterns association across levels neighborhood ses city suggested stronger ors low compared high ses areas evidence non linear effect modification conclusions results suggest ozone associated pediatric respiratory morbidity multiple cities neighborhood ses may modify association non linear manner city children living low ses environments appear especially vulnerable given positive ors high underlying rates respiratory morbidity
patients breast cancer commonly use complementary integrative therapies supportive care cancer treatment manage treatment related side effects however evidence supporting use therapies oncology setting limited report provides updated clinical practice guidelines society integrative oncology use integrative therapies specific clinical indications breast cancer treatment including anxiety stress depression mood disorders fatigue quality life physical functioning chemotherapy induced nausea vomiting lymphedema chemotherapy induced peripheral neuropathy pain sleep disturbance clinical practice guidelines based systematic literature review music therapy meditation stress management yoga recommended anxiety stress reduction meditation relaxation yoga massage music therapy recommended depression mood disorders meditation yoga recommended improve quality life acupressure acupuncture recommended reducing chemotherapy induced nausea vomiting acetyl carnitine recommended prevent chemotherapy induced peripheral neuropathy due possibility harm strong evidence supports use ingested dietary supplements manage breast cancer treatment related side effects summary growing body evidence supporting use integrative therapies especially mind body therapies effective supportive care strategies breast cancer treatment many integrative practices however remain understudied insufficient evidence definitively recommended avoided american cancer society
paper frequency reconfigurable antenna system directional selectivity presented reconfiguration antennas radiation characteristics wirelessly controlled mobile phone microcontroller antenna system multi element radiator composed four monopoles top hexagonal ground plane addition four rectangular microstrip two elements antenna arrays monopoles microstrip arrays designed contribute communication requirements complete system position orientation topology various antennas optimized achieve required frequency reconfigurability addition variable selective directivity performance whole system fabricated integrated single compact unit controlled microcontroller four servo motors well bluetooth module antenna system tested measured results confirm validity proposed design
studies emotional memory complex events suggest arousal enhances long term memory central peripheral information studies however addressed arousal effect memory distortion aiming investigate relationship arousal true false memories central peripheral information recognition test developed test supported brazilian adaptation cahill mcgaugh slideshow procedure test answered university students one week watched either low high emotional arousal version procedure arousal version story responsible better memory retrieval true peripheral information false central information
much controversy treatment asylum seekers australia recent years australian government continuing enforce hard line stance asylum seekers arrive australia boat present study examined attitudes towards asylum seekers using australian community members june way questionnaire primary research question involved five variables predicted false beliefs asylum seekers specifically measured prejudice third person effect confidence answers given false beliefs asylum seekers regression results indicated main predictors false beliefs right wing political orientation prejudice confidence espousing false beliefs third person effect politicians furthermore community participants accepted large number false beliefs true approximately two thirds participants scoring midpoint reflects similar findings last decade results indicate one believes bottom change nuanced approach needs undertaken community anti prejudice interventions
parenting attachment critical emergence self regulation preschool however studies use general indexes parenting quality failing explore unique contributions sensitivity home quality nature interplay parenting attachment history well understood using sample children national institute child health human development study early child care youth development series structural equation models fit determine whether sensitivity home quality concurrently predicted months whether attachment mediated moderated pathways results suggest sensitivity home quality uniquely predict early parenting variables indirectly associated children attachment history higher levels sensitivity home quality predicted secure attachment history along parenting predicted advanced skills months moderated pathways emerged suggesting attachment history may best conceptualized mediating mechanism
commonly applied method fluorescence detection chip gel electrophoresis finish line detection epifluorescence configuration using highly sensitive photodiode cooled scientific camera photodetector paper aim confirm simple optical configuration based limited number components low cost non cooled ccd matrix detector combined software image processing makes possible sensitive fluorescence detection high resolution chip gel electrophoresis position dimensions software defined detection areas called regions interest identified main factors influencing detection properties several parameters typify electropherograms including signal noise ratio full width half maximum peaks studied finally developed detection unit used separation dna ladder theoretical number separation plates thus applicability detection unit confirmed elsevier rights reserved
jet engine prime flight controller post stall flight domains conventional flight control fails engine prevents catastrophes training combat loss airframe hydraulics engine retains hydraulics loss one engine pilot errors icing wings landing gear runway issues takeoff landing bad whether recoveries scientific term revolutionary technology jet steering engineering practice thrust vectoring jet steering advanced fighter aircraft designs integrated stealth technology resulting classified thrust vectoring stealth tvs technology generated second jet revolution air sea propulsion science reassessed classified tvs vehicles stand front revolution recent transfers sensitive technologies south korea japan raised various fundamental issues evaluated editorial review one perhaps key conclusion presented means south korea japan may missed one air sea defenses develop field low cost unmanned fleets jet drones use expensive tvs fighter aircraft highly congested areas turn russia china currently developing fleets various tvs levels sizes china instance operates least drones uavs civilian sector alone chinese drones developed least developers manufacturers mobile telecommunication safe links flyers combat drones ucavs increasingly deep penetrations remote congested areas gradually purchased developed deployed operated extant cader tens thousands national champion flyers already mastered operation mini drones free sport clubs national competions awards rule also provide references different unclassified technology enhances induced flight safety passenger jets turboprops helicopters based patented stowed away emergency deployed kits added fixed configuration subsonic exhaust nozzles low thrust weight ratio vehicles expected benefits include anti terror recoveries emergencies like forced landing unprepared runways highways recoveries airframe hydraulics outs asymmetric ice wings landing gear catastrophes recoveries pilot errors bad whether incidents rule technologies involve preventing catastrophes speed patrol boats racing regular cars suvs buses trucks rule faster helicopters rule
staggering prevalence obesity obesity related health conditions takes exorbitant tolls health care resources cross sectional study private evaluations adult inmates southern state prison conducted regressions comparing obese body mass index bmi nonobese individuals define obesity risk factors obese individuals likely female victims childhood sexual abuse suffered greater severity childhood sexual abuse attempted suicide reported drug dependency non caucasian older nonobese psychopathy predicted lower bmi though obesity might expected victims childhood physical abuse traumatic brain injury mental health conditions due mobility decision making deficits neither significant adjusting related variables childhood sexual abuse remained significant females attempted suicide frequently suffered greater childhood sexual abuse
traditional bag words approach found wide range applications computer vision standard pipeline consists generation visual vocabulary quantization features histograms visual words classification step usually support vector machine combination non linear kernel used given large amounts data however model suffers lack discriminative power applies particularly action recognition vast amount video features needs subsampled unsupervised visual vocabulary generation moreover kernel computation expensive large datasets work propose recurrent neural network equivalent traditional bag words approach enables application discriminative training model allows incorporate kernel computation neural network directly solving complexity issue allowing represent complete classification system within single network evaluate method four recent action recognition benchmarks show conventional model well sparse coding methods outperformed elsevier inc rights reserved
study performed adult italian subjects focus effects dietary calcium intake bone health higher fracture risk appears associated reduced calcium intake adequate daily calcium intake recommended counteract osteoporotic fractures purpose principal aim present study focus effects dietary calcium intake bone mineral density bmd fragility fractures representative sample adult italian outpatient population methods study group consisted consecutive adult italian subjects women men referred bone metabolic diseases unit evaluation bone metabolism daily dietary calcium intake assessed using specific food frequency questionnaire ffq evaluations included fracture risk lumbar femoral bmd heel ultrasound fragility fractures plasma concentration parathyroid hormone pth hydroxy vitamin urinary calcium results subjects daily calcium intake adequate adults day correlation found calcium intake bmd transition daily dietary calcium intake day daily dietary calcium intake day associated reduced fracture probability ratio site subjects one vertebral fractures significantly lower dietary calcium intake day subjects without vertebral fractures practiced physical activity occasionally conclusions daily dietary calcium intake lower recommended daily intake italian ambulatory population higher fracture risk appears associated reduced calcium intake age adequate daily calcium intake combined regular physical activity strongly recommended order counteract fragility fractures
paper devoted analysis utilization possibilities suitable similarity criteria physical modelling transfer processes metal slag including presence third gaseous phase attention also devoted modelling results simulation methodology element transfer ladle modelling done physical model ladle constructed geometric scale located laboratory physical numerical modelling department metallurgy faculty metallurgy materials engineering first discussion deals option converting operating variables laboratory values vice versa suitability chosen similarity criteria individual methodology simulation also discussed results physical modelling transfer homogenization processes used input data discussion also focused factors affecting intensity processes real operating conditions secondary metallurgy equipment analysis results final recommendations lead expansion physical modelling techniques results complementation data obtained numerical modelling department metallurgy together department physical chemistry theory technological processes involved regional materials science technology centre project research program project workplaces created laboratory modelling processes liquid solid phases newly purchased equipment existing human material laboratory facilities provide new opportunities conducting applied research field transfer homogenization processes ladle
paper novel versatile active building block differential input buffered transconductance amplifier dbta proposed application newly defined active function block shown design voltage mode multi input single output miso type multifunction biquad employing single dbta five passive elements proposed filter structure realize four filter functions low band high pass band stop without changing circuit topology enables independent control quality factor using single passive element theoretical results verified pspice simulations using bjt realization dbta
objective accurate diagnosis appropriate management psoriatic arthritis psa essential avoid unnecessary morbidity aim study evaluate current approach management psa among rheumatologists methods item online questionnaire produced using delphi method submitted panel rheumatologists anonymously expressed opinions scale maximum disagreement maximum agreement positive consensus defined respondents scoring item negative consensus defined respondents scoring item results surveyed rheumatologists agreed early stage psa characterised involvement joints entheses psoriasis although possibly absent present patient past personal family history consensus among rheumatologists regarding normalisation reactive protein levels erythrocyte sedimentation rates defining remission specialists believed clinical remission achieved frequently longer among patients psa rheumatoid arthritis participants believed neutralising antibodies altered efficacy anti tumour necrosis factor agents monoclonal antibodies induced greater production neutralising antibodies receptor proteins however knowledge somewhat lacking relation prophylaxis latent tuberculosis conclusion data collected showed surveyed rheumatologists good knowledge diagnosis early stage psa good understanding management relation clinical phenotype exception form predominantly axial involvement
study data driven optimisation solution operational index control class industrial processes presented first operational index control problem formulated optimal tracking control problem augmented system composed device loop dynamics operational indices dynamics constructed two different time scales since finding mathematical model operational indices dynamics difficult contrast existing operational optimisation control methods use mathematical model operational indices dynamics reinforcement learning algorithm based actor critic structure employed provide data driven optimisation control method select optimal process setpoints operational indices track desired values solution require complete knowledge industrial process dynamics moreover complicated system identification dynamics operational indices required effectiveness proposed method demonstrated experimental results carried hardware loop emulation system mineral grinding process
alzheimer disease progressive neurodegenerative disease links conditions often modified dietary life style interventions particular coconut oil received attention potentially benefits lessening cognitive deficits associated alzheimer disease recent report showed neuron survival cultures treated coconut oil rescued compared cultures exposed investigated treatment beta followed addition coconut oil treatment coconut oil followed beta exposure various periods neuronal survival several cellular parameters cleaved caspase synaptophysin labeling ros assessed addition influence treatments relevant signaling pathways investigated western blotting terms treatment timing data indicated coconut oil rescues cells pre exposed beta less effective pre exposure however pretreatment coconut oil prior beta exposure showed best outcomes treatment octanoic lauric acid also provided protection beta effective complete oil coconut oil treatment reduced number cells cleaved caspase ros labeling well rescuing loss synaptophysin labeling observed beta treatment treatment coconut oil well octanoic decanoic lauric acids resulted modest increase ketone bodies compared controls biochemical data suggest akt erk activation may contribute survival promoting influence coconut oil supported observations kinase inhibitor blocked rescue effect cooil beta amyloid toxicity studies mechanisms action coconut oil constituent medium chain fatty acids warranted elsevier ltd rights reserved
discreteness device parameters exists analog signal processing using conventional phase measurement methods error caused threshold voltage comparator difficult estimate eliminate due shortcoming method based tmsf ecap module measuring phase difference presented firstly signal amplified filtered eliminate error introduced electromagnetic interference digital signal schmitt trigger designed cpld converted wave signal frequency signal capturing edge triggered enters capture interruption subroutine calculate number sampling points one period finally phase difference calculated according correlation method hardware circuit software flow chart given experimental results verify method higher reliability precision conventional methods
allergic asthma disease airways driven maladaptive helper immune response harmless airborne substances hallmarks disease airway hyperresponsiveness ahr eosinophilic neutrophilic airway inflammation mucus overproduction distinct dendric cell subsets together airway epithelial pulmonary vascular endothelial cells play critical roles allergen sensing driving cell differentiation towards effector regulatory cells treg previous studies suggested already pivotal role anaphylatoxins pathogenesis allergic asthma sensitization example described promotes whereas protects development maladaptive immunity allergen sensitization discuss role anaphylatoxins receptors pathogenesis allergic asthma specifically lung biology also look canonical non canonical complement activation discuss novel concepts adaptive immune system regulate function atrs also context allergic asthma elsevier ltd rights reserved
main goal introducing identity based cryptosystem certificateless cryptosystem avoiding certificates management costs turn goal introducing certificate based cryptosystem solve certificate revocation problem paper propose new digital implicit explicit certificates based hess signature cbhs scheme combines features standard public key infrastructure pki certificate based cryptosystem cbhs scheme efficient certificates based signature security analysis proves scheme secure two game attacks random oracle model security closely related difficulty solving computational diffie hellman discrete logarithm problems cbhs scheme compared signature schemes similar efficiency flexible useful practice possible revoke explicit certificate use fact digital signature verification thus scheme useful applications typical mechanisms standard pki used one many important security features resistance denial signature verification attack also impossible trusted authority recreate partial private key even cooperation signer
diseases including genetic origin express continuum severity clinical interventions numerous diseases based severity phenotype predicting severity due genetic variants could facilitate diagnosis choice therapy although computational predictions used evidence classifying disease relevance genetic variants special tools predicting disease severity large scale missing manually curated dataset containing variants leading severe less severe phenotypes studied abilities variation impact predictors distinguish found tools separate two groups variants developed novel machine learning based method pon classification amino acid substitutions associated benign severe less severe phenotypes tested method using independent test dataset variants four additional proteins distinguishing severe nonsevere variants pon showed accuracy test dataset higher existing tolerance prediction methods pon first generic tool developed task tool used together evidence improving diagnosis prognosis prioritization preventive interventions clinical monitoring molecular tests wiley periodicals inc
phase study evaluated safety anti tumor activity pembrolizumab japanese patients advanced melanoma pembrolizumab given every weeks years confirmed progression unacceptable toxicity tumor response assessed per response evaluation criteria solid tumors version recist investigator review central review forty two patients advanced melanoma received pembrolizumab primary cutaneous histology observed patients primary mucosal histology observed patients thirty four patients experienced treatment related adverse events aes common treatment related aes pruritus maculopapular rash malaise hypothyroidism grade treatment related aes occurred patients grade treatment related reported least two patients anemia two treatment related deaths unknown cause cerebral hemorrhage among evaluable patients confirmed overall response rates orrs determined central review cutaneous melanoma mucosal melanoma responses durable median duration response reached either population median overall survival reached month cutaneous melanoma mucosal melanoma safety profile pembrolizumab japanese patients similar reported previous clinical studies pembrolizumab provided promising anti tumor activity japanese patients advanced melanoma
current study compares diagnostic approaches section section iii included diagnostic statistical manual mental disorders dsm american psychiatric association diagnosis antisocial personality disorder aspd terms relations psychopathic traits externalizing behaviors ebs section iii approach aspd explicitly trait based section approach also includes psychopathy specifier created goal making diagnosis aspd congruent psychopathy community sample individuals currently receiving mental health treatment ratings dsm diagnostic approaches compared relation measures psychopathy well indices ebs dsm aspd approaches significantly related psychopathy scores although section iii approach accounted almost twice amount variance compared section approach relatively little predictive advantage however due traits manifested little evidence incremental validity relation existing psychopathy measures ebs exception measure fearless dominance overall dsm section iii diagnostic approach aspd convergent construct psychopathy aspd originally derived improvements however due primarily new trait based focus section iii aspd diagnosis rather assessment personality dysfunction inclusion additional psychopathy specific traits
although rosacea impact physical health limited profound effects person psychological well therefore treating rosacea greatly affect person quality life patient education regarding trigger avoidance skin care techniques moisturizing sun protection important non pharmacologic first steps treating rosacea pharmacologic interventions range topical systemic medications ideal medication choice dependent symptoms severity individual patient despite variety therapeutic options none therapies completely curative therefore research pathophysiology rosacea required order create targeted efficacious treatment options
skin diseases constitute essential health aesthetic problem elderly aim study evaluate knowledge elderly residents public nursing homes participants university third age bialystok poland surrounding factors influencing skin ageing awareness skin conditions agening skin impact skin ageing volunteers study performed april june bialystok two groups among public nursing home residents pnh members university third age years old study made use diagnostic survey conducted via questionnaire prepared authors nearly half surveyed sunbathed past surveyed take part type leisure activity half respondents protected skin using special protective preparations majority bialystok inhabitants surveyed noticed features skin ageing reported birthmarks fungal infections bedsores main skin problems old age nearly half respondents assessed knowledge average poor study showed statistical differences knowledge awareness residents public nursing homes land students university third age use internet group finding information desire receive education field agening skin conditions diseases among elderly level knowledge relatively poor education seniors area increase awareness basic principles skin care prevention marking skin ageing benefits greater knowledge seniors conditions agening skin help reduce medical burden land reduce incidence certain skin diseases furthermore need educating younger population factors skin ageing prevent certain skin conditions become older seniors professionally educated qualified specialists example dermatologists cosmeticians information receive line evidence based medicine
teen women became pregnant totaling pregnancies nationwide women ages pregnancies unintended adolescents disproportionate risk medical complications pregnancy furthermore adolescent parents infants tend suffer poor psychosocial outcomes preventing unintended adolescent pregnancies key public health objectives healthy people screening sexual activity pregnancy risk routine part adolescent visits proven reductions unintended pregnancy teens attained providing access contraception cost promoting effective methods
non rigid video interpolation common computer vision task paper present optical flow approach adopts laplacian cotangent mesh constraint enhance local smoothness similar approach adopts mesh image resolution one vertex per pixel uses angle constraints ensure sensible local deformations image pairs laplacian mesh constraints expressed wholly inside optical flow optimization applied straightforward manner wide range image tracking registration problems evaluate approach testing several benchmark datasets including middlebury garg datasets addition show application method constructing morphable facial models dynamic data
study extends research third person effect examining effect time span media message perceptual behavioral components third person effect using survey hong kong residents study explores perceived media effect news coverage short long term issue predictor intention take action reduce negative effect results revealed third person effect short term messages reverse third person effect first person effect long term messages significant difference discrepancy perceived media effect self others third person perception produced messages short long term issue study also found perceived media effect self stronger predictor intention take action reduce negative effects short long term issue third person effect
water scarcity increasingly severe problem worldwide due factors excessive consumption raw water climate change water pollution unsustainable water resource consumption potential benefits accrue rainwater harvesting decrease demand potable water centralized water sources reduction runoff urban rainwater system reduced risk overflow storm events infiltration practices belong one best management practises able effectively reduce overloading sewage systems case rainwater drainage rainwater regarded alternative sustainable strategies rehabilitation rural urban settlements aspect environmental economic social criteria topic presented paper authors published elsevier ltd
deriving products feature model testing software product lines spls hard task important select minimum number products time consider coverage testing criteria pairwise among factors solve problems multi objective evolutionary algorithms moeas successfully applied however design solution software engineering problems difficult necessary choose among different search operators parameters hyper heuristics help task raised interest search based software engineering sbse field considering growing adoption spl industry crescent demand spl testing approaches paper introduces hyper heuristic approach automatically derive products variability testing spls approach works moeas two selection methods random based frr mab fitness rate rank based multi armed bandit evaluated real fms results show proposed approach outperforms traditional algorithms used literature selection methods present similar performance elsevier rights reserved
alpha ethinylestradiol potent estrogen used birth control pills previous laboratory field studies shown negative impacts variety fish species exposure low levels notably nearly complete shutdown egg production present study demonstrates mummichog fundulus heteroclitus small bodied estuarine species able continue produce eggs exposure effect egg production observed whereas fold increase vitellogenin vtg gene expression males found lack response egg production fish exposed high levels warrants investigations species specific responses estrogens endocrine disruptors general setac
aims maternal malnutrition low protein diet associated increased incidence metabolic disorders decreased male fertility adult life study aimed assess impact maternal protein malnutrition mpm prostate growth tissue organization lesion incidence aging main methods wistar rat dams distributed two groups control fed normal diet containing protein restricted protein diet fed diet containing protein gestation delivery mothers offspring received normal diet biometrical parameters hormonal levels prostates harvested post natal days pnd key findings mpm promoted low birth weight decreased ano genital distance agd reduced androgen plasma levels male pups prostatic lobes groups presented reduced glandular weight epithelial cell height alveolar diameter epithelial cell proliferation collagen deposition increased group incidences epithelial dysplasia prostatitis higher offspring offspring pnd significance findings show mpm delays prostate development growth maturation adulthood probably result low testosterone stimuli higher incidence cellular dysplasia prostatitis suggests mpm increases prostate susceptibility diseases aging elsevier inc rights reserved
saltwater crocodiles crocodylus porosus potentially dangerous humans yet major cultural value many people timor leste recent increases attack risk influencing traditional attitudes threatening culls remaining wild crocodile populations understand patterns may assist mitigation compiled attack records period april april using crocbite online database recorded attacks showed high fatality rate majority recorded since highest proportion attacks occurred southern coastal wetlands suited crocodiles areas representing major sources food livelihoods ecosystem services fisheries timber coastal protection locals subsistence fishing posed highest attack risk particularly september february food security low attacks matched gender roles victims males primary fishers demographic patterns teenagers fastest growth group comprised highest proportion predicted increases food insecurity fishing activities coastal impacts rising human crocodile populations pose worrying implications human crocodile conflict recommend essential baseline surveys enabling meaningful management decisions suggest tailored management educational awareness based proven existing models could substantially mitigate attack risk remaining compatible traditional timorese attitudes towards crocodiles
breast cancer continues frequently diagnosed cancer american women disproportionately affects women african american descent previously reported greater serum levels resistin patients relative caucasian american patients established role growth aggressiveness breast tumor cells investigated role resistin chemoresistance mda mda cells origin respectively incubated resistin prior doxorubicin treatment data suggest resistin conferred chemoresistance cell lines however effect cells profound furthermore resistin induced doxorubicin resistance shown occur due suppression apoptosis resistin treatment also affected stemness cells suggested reduced cell surface expression induced expression aldh increased capability cells form mammospheres mechanistic studies revealed resistin induced chemoresistance apoptosis stemness cells mediated stat activation taken together findings provide novel insight role resistin biology strengthen role racially disparate clinical outcomes elsevier rights reserved
prevalence information communication technologies electronic health services ehs commonly used patients doctors healthcare professionals decrease healthcare costs provide efficient healthcare processes however using ehs increases concerns regarding security privacy integrity healthcare data several solutions proposed address issues ehs survey categorize evaluate state art electronic health system research based architecture well services including access control emergency access sharing searching anonymity methods considering cryptographic approaches survey differs previous ehs related surveys method based proposed services classified based methods compared solutions provide performance comparisons state commonly used methods category also identify relevant open problems provide future research directions elsevier rights reserved
speed binning system chips socs using conventional max test requires application complex functional test patterns functional workload based speed binning techniques incur high test cost terms long test time complexity functional test generation require high end automatic test equipment paper propose novel speed binning flow uses path timing slacks extracted robust digital embedded sensor ips selected critical nearcritical paths apply machine learning techniques model predictor considering extracted slacks fmax values set randomly tested die wafer sort trained predictor used obtain fmax remaining chips proposed flow demonstrated soc benchmark circuit technology sufficient number training samples max correctly predicted prediction samples
etiological models intimate partner violence ipv identify general risk factors delinquency sociodemographic delinquent psychopathological specific factors type aggression characteristics couple relationship attitudes favoring ipv goal present work study factors individuals convicted drug trafficking theft called common delinquents comparing group partner aggressors assessment carried mixed method reviewing case files clinical interviews personality disorders self reports results show similar profile sociodemographic criminal characteristics attitudes favoring ipv differences emerge variables couple relationship psychopathological variables finding higher prevalence antisocial disorder common delinquents borderline disorder aggressors final model identifies level relationship satisfaction control partner blaming female victims incidence borderline personality disorder relevant variables implications results penitentiary treatment preventive measure ipv ipv aggressors general prison population discussed colegio oficial psicologos madrid production elsevier espafia rights reserved
industrial active magnetic bearings ambs controlled proportional integral derivative pid controllers usually time consuming iterative manual tuning procedure required design pid controllers contribution introduce strategy algorithms results amb controller design including optimization using multiobjective genetic algorithm focus combination frequency time domain based optimization strategy evaluation fitness functions complex pid controller design sensitivity based parameter reduction optimization two amb system controller designs considered satisfactory results obtained using suggested optimization strategy validation purposes optimized controller design experimentally implemented first amb system contains flexible test rotor supported two ambs maximal rotational speed min achieved test rotor comparison simulated experimental results presented
background proximal humerus fractures accounts fractures third common fractures elderly population hip distal radius fractures due increasing incidence high velocity trauma fracture pattern proximal humerus fracture becoming complicated always enigma management fractures numerous muscles attachment paucity space fixing implant fracture proximal humerus treatment controversial articular fractures carry high risk humeral head necrosis neer classification two part anatomical neck three part four part fracture dislocation head humerus review published result suggests universally accepted form treatment conservative management may associated non union malunion resulting painful dysfunction object osteosynthesis reduce displacement usually rotation fragment hold place implant greater tuberosity fragment usually displaced proximally rotated upward rotator cuff muscles inserted fixed major humeral head fragment lesser tuberosity fragment similarly displaced subscapularis fixed three four part fractures represent proximal humeral fractures treatment options displaced fractures include open reduction fixation neer recommended open reduction internal fixation displaced two three parts fractures aim present study study undertaken evaluate functional outcome complication proximal humerus fractures treated philos locking plate materials methods prospective study involving adults yrs proximal humerus fractures admitted mgm hospital warangal period years study period cases fractures proximal humerus treated open reduction internal fixation philos locking plate evaluated inclusion criteria two part three part four part proximal humeral fractures acute fracture age patient fit surgery exclusion criteria associated humerus shaft fracture associated neurovascular injury results series majority patients males elderly aged rta commonest mode injury involving part part part fractures proximal humerus fractures united patients excellent satisfactory results found patients unsatisfactory results according neer criteria conclusions conclusion philos locking plate advantageous implant proximal humeral fractures due angular stability particularly comminuted fractures osteoporotic bones elderly patients thus allowing early mobilisation fracture union present study done evaluate functional outcome complication following surgical management proximal humerus fractures treated philos locking compression plate study safely recommended proximal humerus fractures philos plating good choice surgical treatment
inflammation immune activity designed protect host pathogens noxious agents low intensity form presence inflammatory process must inferred appropriate biomarkers occult neuroinflammation secondary alzheimer disease may contribute pathogenesis promote progression leaky blood brain barrier bbb observed early may play role initiation development studies temporal evolution biomarkers shown brain amyloid burden correlates poorly cognitive decline contrast cognitive deficits correlate well synapse loss oligomeric forms amyloid beta beta synaptotoxic evidence deposition inside synaptic terminals cognition associated neurons explains early memory loss better formation extracellular beta plaques among innate immune cells reside brain microglia sense danger signals represented proteins like beta become activated neuronal damage caused bacterial endotoxins resulting reactive microgliosis implicated generating chronic form microglial activation believed promote development genomewide association studies gwass yielded data patients sporadic indicating causes include genetic variation innate immune system recent preclinical studies reported beta hydroxybutyrate beta ohb may protect brain adverse effects nucleotide binding oligomerization domain nod like receptor protein nlrp inflammasome deacetylation histone consequently urgent need clinical investigations designed test whether orally administered beta ohb preparation ketone ester similar beneficial effect human subjects elsevier inc rights reserved
studies demonstrated deficiency estradiol postmenopausal women influences immune system however studies reported alterations immunologic presentation nonnatural menopause young females compared differences immune response young cbl mice surgical medical variectomy aged cbl mice common feature deficiency following con stimulation observed inverted ratios aged group apparent reduced production serum immunoglobin iga igm surgical group whereas changes immune parameters medical group moderate data suggested immunological response con stimulus differed among three groups deficiency partially responsible development immune deficiency aged mice
maize zea mays predominantly grown commercial crop river basins lower krishna telangana south india long term crop water balance analysis maize two sowing windows normal sowing june late sowing july done climate change scenario using scaled climate data gcm model echam crop water balance parameters rainfall effective rainfall crop evapotranspiration irrigation requirements maize two sowing windows estimated using cropwat model base period long term period mid century normal sowing window maize significant variation decadal crop irrigation requirements increasing trend base period amount average decadal rainfall effective rainfall decreased range respectively base period decadal average rainfall effective rainfall showed increasing trends respectively base period late sowing window also crop irrigation requirements exhibited decreasing trend study indicates shift seasonal rainfall normal sowing window june july extends october november season indicating rainfall late sowing window maize scope rainwater harvesting lower krishna river basin sustaining maize production
present knowledge seasonal affective disorder sad based mainly clinical symptoms epidemiology behavioral characteristics light therapy recently developed measures resting state functional brain activity might provide neurobiological markers brain disorders studying functional brain activity sad could enhance understanding nature possible treatment strategies functional network connectivity measured using ica dual regression amplitude low frequency fluctuations alff measured antidepressant free patients diagnosed sad compared age gender ethnicity matched healthy controls hcs using resting state functional magnetic resonance imaging correcting type error high model orders inter rsn correction sad patients showed significantly increased functional connectivity identified rsns increased functional connectivity involved rsns visual sensorimotor attentional networks moreover results revealed sad patients compared hcs showed significant higher alff visual right sensorimotor cortex abnormally altered functional activity detected sad supports previously reported attentional psychomotor symptoms patients suffering sad studies particularly task conditions needed order specifically investigate cognitive deficits sad hum brain mapp wiley periodicals inc
purpose following paper interview conducted joanne pransky industrial robot journal method impart combined technological business personal experience prominent robotic industry engineer turned successful innovator leader regarding challenges bringing technological discoveries fruition paper aims discuss issues design methodology approach interviewee gianmarco veruggio responsible operational unit genoa italian national research council institute electronics computer telecommunication engineering cnr ieiit veruggio early pioneer telerobotics extreme environments veruggio founded new applicative field roboethics interview veruggio shares year robotic journey along thoughts concerns robotics society findings gianmarco veruggio received master degree electronic engineering computer science control automation genoa university worked automation division ansaldo designer fault tolerant multiprocessor architectures fail safe control systems part development team new automation italian railway stations joined cnr institute naval automation ian genoa research scientist worked real time computer graphics simulation control techniques naval marine data collection systems founded cnr ian robotics department robotlab headed develop missions experimental robotics extreme environments approach utilized working prototypes virtual lab environment focused robot mission control real time human machine interfaces networked control system architectures tele robotics internet robotics founded association scuola robotica school robotics promote new science among young people society large means educational robotics joined cnr ieiit continue research robotics also develop studies philosophical social ethical implications robotics originality value veruggio led first italian underwater robotics campaigns antarctica italian expeditions arctic antarctic expedition carried robot project first experiment internet robotics via satellite antarctica designed developed project robot first experiment worldwide internet robotics ever carried arctic projects organized series live science sessions collaboration students teachers italian schools beginning new school robotics veruggio continued disseminate educate young people complex relationship robotics society led coin term propose concept roboethics since made worldwide efforts dedicating resources development new field general chair first international symposium roboethics euron roboethics atelier produced roboethics roadmap veruggio author scientific publications presented ligurian region award innovation merits field science society awarded title commander order merit italian republic one italy highest civilian honors
background elderly subjects renal insufficiency osteoporosis often coexist high risk fracture elevated socio economic burden today large number effective anti osteoporotic drugs available generally contraindicated patients chronic kidney disease ckd progressive accumulation denosumab instead require dose adjustments different degrees renal impairment valid treatment osteoporotic patients ckd limited data available literature concerning use denosumab hemodialysis aim study therefore study efficacy tolerability drug particular subset patients methods retrospectively reviewed charts osteoporotic patients received single subcutaneous dose denosumab every months observation period months serum electrolyte markers bone turnover quantitative ultrasound qus evaluated results months observed gradual improvement bone metabolism beta crosslaps bone alkaline phosphatase balp mcg qus index score risk fracture cases hypocalcemia detected significant first second injection careful monitoring serum calcium rapid therapy adjustment could easily manage serum levels conclusions pilot experience highlights safety efficacy denosumab treatment osteoporosis patients potentially supporting use reduce burden fractures patient population
current guidelines suggest polycythemia vera patients maintain strict hematocrit less however date little known relationship hct control related symptom burden study patient data analyzed cyto trial mpn saf study cohort significant differences symptom burden seen month follow evaluating prospective hematocrit control cyto cohort patients mpn saf cohort worst item score greater myeloproliferative neoplasm symptom total symptom score significantly lower mean hematocrit findings suggest relationship traditional aggressive therapy increased symptom burden prolonged therapy thus symptom burden considered contemplating choice therapy second line setting
although dyslipidemia increases risk ischemic stroke previous studies reported conflicting data regarding association lipid levels stroke severity outcome evaluate predictive value major lipids patients acute ischemic stroke prospectively studied consecutive patients admitted acute ischemic stroke males age years severity stroke assessed admission national institutes health stroke scale nihss moderate severe stroke defined nihss outcome assessed dependency rates discharge modified rankin scale hospital mortality independent predictors moderate severe stroke age relative risk confidence interval atrial fibrillation heart rate log triglyceride levels high density lipoprotein cholesterol hdl levels major lipids predict dependency discharge independent predictors hospital mortality atrial fibrillation diastolic blood pressure log levels nihss admission low density lipoprotein cholesterol levels associated stroke severity outcome lower hdl levels associated severe stroke lower levels also appear predict hospital mortality patients acute ischemic stroke
objectives close relationship major depression sleep disturbances led hypothesis deficiency homeostatic sleep pressure depression deficiency hypothesis many observed changes sleep characteristics depression also present healthy aging leading premise sleep depression resembles premature aging study aimed quantifying homeostatic sleep wake regulation young women major depression healthy young older controls high sleep pressure conditions methods baseline night nine depressed women eight healthy young eight healthy older women underwent sustained wakefulness protocol followed recovery night constant routine conditions polysomnographic recordings carried continuously sleep parameters well time course eeg slow wave activity swa eeg spectra range marker homeostatic sleep pressure analyzed recovery night results young depressed women exhibited higher absolute mean swa levels stronger response sleep deprivation particularly frontal brain regions contrast healthy older women exhibited attenuated swa values compared two groups also absence frontal swa predominance conclusions homeostatic sleep regulation sleep architecture young depressed women equal premature aging moreover findings demonstrate young moderately depressed women exhibit deficiency sleep homeostatic process predicted deficiency hypothesis rather live elevated level homeostatic sleep pressure elsevier rights reserved
background periaqueductal gray pag substantial descending pain modulatory center previous voxel based morphometry study confirmed clusters increased volume pag region medication overuse headache moh aim study investigate altered pag volume moh using automated pag segment method measure true pag volume methods high resolution three dimensional weighted fast spoiled gradient recalled echo images obtained patients moh normal controls pag template created based icbm gray template individual pag generated applying deformation field structural image segment pag template individual pag volume calculated results significant increased volume pag moh area receiver operating characteristic roc curve cut pag volume sensitivity specificity conclusion present study demonstrated pag volume gain confirmed moh patients automated individual pag volume measure may considered simple effective imaging biomarker moh diagnosis
paper propose novel technique tuning enhancing performances current conveyor based active circuits basic idea consists judiciously adding controlled sources signal flow graph representing active circuits potentiality proposed technique showcased five different examples namely enhancing performances parallel serial simplified circuits enhancing performances fourth order ladder filter tuning performances active second order filter tuning inductance value active inductors viability supported spice simulation results
objective research design inexpensive mechanism testing cargo separation wind tunnel designed mechanism simulates separation naca airfoil upper wall wind tunnel perform test used low speed wind tunnel test chamber first electromagnets fix model initial position wind tunnel reaches required speed power cut model releases test begins finally movements stopped spring limiters test finishes process filmed test special cameras using image processing diagrams respect time presented test results also two accelerometers installed mechanism along directions store acceleration respect time make possible calculate velocity position body moment limitations costs availability market aerodynamic structure also studied design process create aerodynamic conditions circular plates fixed beginning end wing provide appropriate structural strength safety factor diameter horizontal vertical steel rails considered respectively
research suggests worry precludes emotional processing well biases attentional processes although burgeoning evidence relationship executive functioning worry research area needed recent theory suggests one mechanism negative effects worry neural indicators attention may working memory load however studies examined directly goal current study document influence visual verbal working memory load worry attention allocation processing emotional images cued image paradigm hypothesized working memory load decrease attention allocation processing emotional images tested among participants using modified paradigm results indicated visual verbal working memory tasks resulted reduction attention allocation processing images across stimulus types compared baseline task although individuals low worry data extend literature documenting decreased neural responding lpp amplitude imagery visual verbal working memory load particularly among individuals low worry
article presents automatic generation control agc interconnected four area thermal system control areas provided single reheat turbine generation rate constraints min maiden attempt made apply proportional integral proportional derivative cascade controller agc controller gains optimized simultaneously using flower pollination algorithm fpa recent evolutionary computational technique performance classical controllers integral proportional integral proportional integral derivative pid controller investigated compared cascade controller investigations reveal comparison cascade controller provides much better response others performances comparison several objective functions evaluated explored integral squared error better others system cascade controller sensitivity analysis reveals fpa optimized cascade controller parameters obtained nominal condition loading size position disturbance system parameter inertia constant robust need reset wide changes system loading size position disturbance system parameters system dynamic performances studied step load perturbation random load area elsevier ltd rights reserved
background levonorgestrel lng commonly used emergency contraceptive effect sex hormone levels female blood objective study develop validate specific sensitive method monitoring endogenous sex hormone levels beta estradiol progesterone female plasma administration lng results methodology method developed optimized validated according ema guideline assay validation met criteria including good linearity range beta estradiol well lng progesterone conclusion method preliminarily applied explore variation trend sex hormone levels healthy chinese female volunteers plasma oral administration lng tablet lng absorption plasma progesterone estradiol levels descended rapidly maintained low levels onset time
paper design new virtual queue based back pressure scheduling algorithm vbr achieving significant delay reduction wireless sensor networks wsn algorithm design comes observation classical back pressure scheduling algorithm usually needs long period time form queue backlog based gradient network decreases towards sink network achieving stable packet delivery performance address issue vbr designed pre build proper virtual queue based gradient nodes wsn chosen function traffic arrival rate link rate distance sink order adaptive different network application environments achieving high network performance moreover queue backlog differential pair neighbor nodes decided actual queue lengths also virtual queue lengths gradient values prove vbr maintain back pressure scheduling throughput optimality simulation result shows vbr obtain significant performance improvement terms packet delivery ratio average end end delay average queue length compared existing work
splitting behavioural activity phase found nocturnal rodents suprachiasmatic nucleus scn coupling disorder similar phenomenon observed sleep phase diurnal human discussed suggesting called evening morning oscillators scn humans present case suffered bipolar disorder refractory various treatments various circadian rhythm sleep disorders delayed sleep phase polyphasic sleep separation sleep bout resembling splitting circabidian rhythm found prolonged depressive episodes hypersomnia separation sleep evening morning components delayed sleep offset cycle developed lowering stopping dose aripiprazole apz however resumption apz improved symptoms weeks accompanied improvement patient depressive state administration apz may improve various circadian rhythm sleep disorders well improve prevent manic depressive episodes via augmentation coupling scn network
pilot study examined usability acceptability effectiveness free provider resilience mobile application app designed national center telehealth technology reduce provider burnout outpatient mental health providers used app month participants rated app system usability scale overall score top quartile usability results paired sample tests professional quality life scale indicated significant decreases burnout compassion fatigue subscales provider resilience app shows promise reducing burnout compassion fatigue mental health care providers
universitat politecnica catalunya upc barcelonatech list generic skills included degrees focus materials science engineering community practice gidmat related rima http www upc edu rima project gidmat focus teaching innovation developing new learning methodologies learning methodology generic skill working teams developed based structured rotation roles within working teams teams results compared evaluation generic skill autonomous learning new methodology provides students benefits knowledge skills acquisition docent improved assessment results relative low cost time dedication published elsevier ltd selection peer review responsibility prof huseyin uzunboylu
based target induced immuno proximity binding metal ion dependent dnazyme recycling signal amplification describe development homogeneous sensitive fluorescent method detection protein cancer biomarkers using alpha fetoprotein afp model target two dna strands short complementary regions conjugated afp antibodies prepare recognition probes hybridization two dnas absence afp target molecules inhibited due low melting temperature complementary regions binding antibody linked dnas afp target molecules increase local effective concentrations two dnas facilitate hybridization significantly increased form catalytic cores metal ion dependent dnazymes fluorescently quenched hairpin substrate sequences bind catalytic cores form dnazymes substrate sequences cyclically cleaved corresponding metal ions generate remarkably enhanced fluorescent signals sensitive detection afp dynamic range detection limit sensing approach also possesses high selectivity toward target afp interfering proteins employed detect afp human serum samples significant signal amplification approach avoids involvement enzyme nanomaterial labels sensitive protein detection realized homogeneous solution makes developed method holds great potential convenient sensitive detection various protein biomarkers early disease diagnosis
study physical layer security techniques studied multi user peer peer relay networks using amplify forward protocol presence eavesdropper two system designs considered minimum achievable secrecy rate maximisation total transmit power minimisation first considering user fairness authors study max min achievable secrecy rate problem subject total transmit power constraint mathematically optimisation problem non linear non convex propose polynomial time algorithm based bisection technique solve second study total transmit power minimisation problem aims minimising total transmit power relays individual secrecy rate user satisfied total power optimisation problem also non convex use relaxation technique transform convex problem efficiently solved gradient based algorithms numerical evaluation obtained secrecy rate transmit power results shows proposed designs significantly improve performance secure wireless communications
army combat training important simulation real battlefield environment great significance two dimensional information unable meet demand present development virtual reality technology three dimensional simulation battlefield environment possible simulation battlefield environment addition terrain combat personnel combat tool simulation explosions fire smoke effects also important since effects enhance senses realism immersion scene however special effects irregular objects make difficult simulate general geometry therefore simulation irregular objects always hot difficult research topic computer graphics particle system algorithm used simulating irregular objects design simulation explosion fire smoke based particle system applied battlefield scene besides battlefield scene simulation glasses free display carried algorithm based gpu super multiview video real time transformation method time human computer interaction function ultimately realized glasses free display simulated realistic immersed battlefield environment
performance electrical generator using bio fuel gasoline blends different composition fuel single cylinder engine presented effect optimized blend ratio bio fuel gasoline engine performance improvement thereby electrical generator output studied bio fuels ethanol butanol methanol blended gasoline different proportions evaluated performance effects different bio fuel gasoline blending ratios compared experimentally gasoline alone using output power developed electric generator evaluation parameter composition ethanol gasoline engine performance increased blending ratio butanol gasoline performance increased compared use gasoline investigations performed portable generator used palm tree harvesting applications
knowledge extracted across previous experiences schemas benefit encoding retention congruent information however also reduce specificity augment memory semantically related false information demonstration latter given deese roediger mcdermott drm paradigm studying words fit common semantic schema found induce false memories words congruent given schema studied medial prefrontal cortex mpfc ascribed function leveraging prior knowledge influence encoding retrieval based imaging patient studies used transcranial magnetic stimulation tms transiently perturb ongoing mpfc processing immediately participants performed drm task observed predicted reduction false recall critical lures mpfc perturbation compared two control groups whereas veridical recall recognition memory performance remained similar across groups data provide initial causal evidence role mpfc biasing assimilation new memories consolidation function prior knowledge elsevier ltd rights reserved
introduction study investigated effects testosterone treatment cognition mood quality life men mild cognitive impairment mci low serum levels methods total community dwelling men screened men evidenced mci low agreed screening twenty two met study inclusion exclusion criteria enrolled month randomized double blind placebo controlled study results total levels significantly increased treatment group significant changes observed measures cognition mood quality life improvement objective measure verbal memory decreased depression symptoms treatment group conclusions testosterone treatment may modestly improve verbal memory depression symptoms men mci low
media violence continues concern parents policy makers researchers spite confidence expressed exposure television violence causes serious aggression violent crime critics hold serious flaws research methodology limits nullifies conclusions drawn widely cited studies paper examine series classic studies lessons learned conducting media violence research assess whether recent publications adhere standards conclude empirical reports serious flaws continue published compromising ability understand phenomenon elsevier ltd rights reserved
radiation therapy key treatment modality cancer patients associated adverse side effects radiation dermatitis mitigate adverse effects radiation skin patients must participate skin related self care however even self care instruction adherence poor quality improvement project used best available evidence skin care patients undergoing radiation therapy theoretical framework mating provide structured approach patient education designed enhance adherence skin care recommendations implementation approach resulted increased adherence topical skin care protocol facility patients highly satisfied education day delay onset radiation dermatitis difference statistically significant
research retrospective case study designed document implementation management decisions made storm water pollution prevention plan swppp wastewater project california study project manager qualified storm water pollution prevention practitioner qsp agreed extensive interviews decisions made associated costs laws regulations constructors required take precautionary measures ensure pollutants stay jobsites opposed running storm water system moreover practical standpoint research might particularly useful addressing challenges constructors stringent sustainability regulations study used retrospective case study part exploratory qualitative research strategy examining costs associated storm water pollution prevention twenty acre wastewater project construction schedule two years cost analysis taken historical data applied quantity takeoff study aimed documenting practical features actual implementation management cost particular case results indicate primary roles qsp project swppp cost project total project cost published elsevier ltd
inappropriate management industrial effluents among major causes water pollution subsequent fish physiological behavioral disorders mortalities study investigated effects wastewater paper mill immune related gene expressions lysozyme tumor necrosis factor heat shock protein hematological alterations juvenile rainbow trout oncorhynchus mykiss day exposure period following determination fish body weight exposed three effluent treatments control laboratory conditions wastewater exposure initially increased lysozyme tumor necrosis factor gene expression expression genes suppressed day exposure rise heat shock protein gene expression beginning experiment decreased level observed control group fish exposed wastewater showed significant increase levels red blood cells white blood cells hematocrit three days following exposure levels blood parameters significantly decreased end exposure period results indicated range immune related gene toxicity hematotoxicity rainbow trout caused negative impacts industrial wastewater also discussed poor biosecurity controls inadequate treatments effluents industrial activities lead serious damages among wild populations
variable number tandem repeat polymorphism vntr period per gene associated heritable sleep circadian variables including self rated chronotypes polysomnographic psg variables insomnia circadian sleep wake disorders report describes novel molecular clinical analyses per vntr polymorphisms better define functional consequences per vntr located exonic protein coding region per initially investigated whether alleles variants transcribed messenger rna human fibroblasts vntr showed allelic gene expression next investigated genetic associations relation clinical variables older adult caucasian individuals independent variables included genotypes per vntr well representative set single nucleotide polymorphisms snps tag common variants per locus linkage disequilibrium genetic variants order comprehensively evaluate variables analyzed individually prior analyses dependent measures included psg total sleep time sleep latency self rated chronotype estimated composite scale lifestyle regularity estimated using social rhythm metric srm initially genetic polymorphisms individually analyzed relation outcome variable using analysis variance anova nominally significant associations tested using regression analyses incorporated individual anova associated dna variants potential predictors selected sleep circadian variables outcomes covariates included age gender body mass index index medical morbidity significant genetic associations vntr detected sleep circadian variables nominally significant associations detected snp scores srm average delta power analyses uncorrected multiple comparisons conclusion alleles vntr expressed transcript level may functional effect cells expressing per gene per polymorphisms modest impact selected sleep circadian variables sample suggesting per associated sleep circadian function beyond vntr polymorphisms replicate analyses larger independent samples recommended
paper presents study regarding implementation actuators use special smart material springs system relates actuator formed two elements one fixed one mobile attached force measuring device two elements placed number springs made material special properties springs heated different temperatures give rise tangential force paper presents characteristics embodied force variation developed material according applied temperature characteristics concerning forces developed material based applied electrical current heated resistance results lead development high performance actuators rotary motors based nitinol properties
accessible summary known subject growing emphasis communication result move towards inclusive approach associated community based rehabilitation model therefore importance attached handovers besides ensuring transfer information handovers enhance group cohesion socialize staff members practices service capture organizational culture paper adds existing knowledge handovers mainly used information transfer manage services daily routine paper offers insight handovers conceived valuable instruments document cultural organizational change limited amount studies focused handovers mental healthcare settings consider perspectives psychiatric nurses embracing broader perspective paper provides valuable insights perspectives various service providers overcoming dichotomy deficit based recovery oriented model possible professionals use handovers reflect upon practice ways cultural models affected environmental context implications practice handovers valuable instruments document organizational change would important psychiatric rehabilitation facilities keep track handover records time may provide insightful information cultural change transformations core values beliefs held professionals abstract handovers assure timely correct information transfer socializing workers service culture however study describes instruments document organizational change focused psychiatric settings aim investigate change culture italian psychiatric residential care home perceived mental health workers mhws course two decades method emotional text analysis eta used analyse mhws handovers completed results analysis generated four clusters three main factors illustrating change mhws representations residential care home occupants factors showed shift individualistic problem focused view inclusive community based approach presence descriptive well specialized language presence double focus patients professionals conclusions handovers transcripts document following changes shift symptom based recovery oriented approach modification mhws values towards holistic view patient growing importance assigned accountability services integration teamwork paper shows handovers used diachronically document organizational change
rapid development medical imaging technology computer graphics visualization technologies virtual endoscopy technology emerged mainly includes medical image segmentation image reconstruction path planning virtual roaming however path planning virtual endoscopy become one obstacles field due high irregularity nasopharyngeal anatomy structure study nasopharynx including meatus nasi pharyngeal canal maxillary sinus frontal sinus sphenoid sinus ethmoid sinus segmented reconstructed using images key technology virtual endoscopy center path planning algorithm implemented based distance transform also two improved algorithms center path planning proposed one selection algorithm branch path extraction algorithm complex path based human computer interaction two improved algorithms allow traditional path planning algorithm handle multiple branching structure make roaming path start point experimental results satisfied needs clinical practice
study explored influences living arrangements orphans vulnerable children ovc housed community based home johannesburg south africa total ovc males females age range years completed open ended questionnaire also participated individual interviews focus group discussions became residents community based home data thematically analysed findings suggest choice live community based care setting influenced homelessness accompanying poverty health issues experiences child abuse neglect discrimination domestic violence school psychologists working ovc community based homes consider pathways children could provided needed support resilient health wellness
dynamic characteristic important machine design controller design permanent magnet synchronous machine pmsm paper experiment corresponding test bench estimating dynamic characteristic pmsm proposed suitable apply various variable load torque tested machine experimental platform consists two pmsms one called tested machine another load machine tested one run speed control mode load one run torque control mode load machine applied sinusoidal torque load variable frequency amplitude phase load sinusoidal tested motor motoring generating alternating state experiment experimental data tested machine load machine recorded computer found analyzing experimental data tested machine corresponding drive system able accurately track load torque excellent dynamic characteristics
objectives study aimed identify clusters based diagnostic status mental disorders among individuals problematic substance use treated addiction rehabilitation center arc characterize clusters according socio demographic variables neighborhood characteristics health service utilization methods data compiled individuals problematic substance use received services arc data compiled merging four databases arc data registry quebec health insurance board database quebec provincial database hospitalizations quebec national institute public health database two step cluster analysis performed generate distinct groups based diagnostic categories mental disorders complementary comparative analyses conducted test differences among clusters results three clusters identified first cluster consisted individuals receive diagnosis mental disorder including substance use disorders suds low users health services second cluster composed individuals received diagnosis mental disorder sud primarily used mental health services third cluster included individuals dual diagnosis occurring sud mental disorder high users acute care services conclusions study highlights heterogeneity individuals problematic substance use treated arc treatment effective overall tailored varying needs individuals problematic substance use recommendations study geared toward improving effectiveness care population include systematic diagnostic screening suds physicians developing strong primary care individuals problematic substance use ensuring continuing care model individuals dual diagnosis elsevier inc rights reserved
hybrid combined cooling heating power cchp system driven biomass solar energy proposed complementarity enhance system energy efficiency analyzed shown cchp system primarily composed biomass gasification sub system solar evacuated collector internal combustion engine dual source powered mixed effect absorption chiller product gas produced gasifier drives internal combustion engine generate power waste heat generation utilized produce cooling heating collected heat solar collectors design conditions thermodynamic performances variable external conditions energy ratios investigated analyzed results indicate primary energy ratio exergy efficiency respectively carbon emission reduction ratio design condition complementarity analysis biomass solar energy shows biomass subsystem makes greater contribution total system primary energy ratio exergy efficiency contributions solar subsystem participation solar energy conducive system emission reduction elsevier ltd rights reserved
paper presents new innovative concept regarding propulsion system non autonomous electric vehicles trolley buses trams subway frames system main part electric hydraulic generator generator converts electrical energy hydrostatic energy stored accumulator using hydraulic motor hydrostatic energy converted motor torque form rotational motion electric motor operates single regime electric consumption reduced also new system ensures better dynamic performances operational safety
statistical learning theory slt defines five assumptions ensure learning supervised algorithms data independency one assumptions slt relies law large numbers ensure learning bounds consequence assumption imposes strong limitation guarantee learning time dependent scenarios order tackle issue researchers relax assumption detriment invalidating theoretical results provided slt paper apply kernel function precisely takens immersion theorem reconstruct time dependent openended sequences observations also referred data streams context machine learning multidimensional spaces phase spaces attempt hold data independency assumption first study best immersion parameterization kernel function using distance weighted nearest neighbors dwnn next use best immersion recursively forecast next observations based prediction horizon estimated using lyapunov exponent afterwards predicted observations compared expected ones using mean distance diagonal line mddl theoretical experimental results based cross validation strategy provide stronger evidences generalization allows conclude one learn time dependent data using approach opens important possibility ensuring supervised learning comes time dependent data useful tackle applications climate animal tracking biology domains elsevier ltd rights reserved
postharvest exposure useful delay senescence induce accumulation bioactive compounds vegetable species however studies conducted determine treatment conditions radiation dose intensity required maximize two diverse responses work evaluated effect irradiation intensity control low medium high dose quality retention antioxidant capacity fresh broccoli florets storage degrees days exposure low radiation dose reduced broccoli weight loss delayed yellowing improved chlorophyll chlorophyllide retention long term storage marked improvement antioxidant capacity found regardless irradiation condition evaluations short time exposure indicated treatments elicited antioxidant accumulation greatest antioxidant capacity found broccoli subjected high intensity increased levels aliphatic glucosinolates found irradiation whereas phenolic antioxidants peaked treatment results showed low doses intensities delayed chlorophyll degradation may useful complement refrigeration fresh broccoli instead high intensity exposure may better suited pre treatment increase antioxidant capacity prior processing freezing elsevier rights reserved
microwave multiplexers multi port structures composed several two port filters connected common junction paper addresses embedding problem goal determine filtering components given measured scattering parameters overall multiplexer several frequencies due structural properties transmission zeros filters play crucial role problem consequently approach propose system identification algorithm deriving rational model filters scattering matrix approach based rational interpolation derivative constraints interpolation conditions located precisely filters transmission zeros elsevier ltd rights reserved
paper new quantum encryption based key controlled chained cnot operations named kccc encryption proposed kccc encryption improved arbitrated quantum signature aqs protocol presented compared existing protocols protocol effectively prevent forgery attacks disavowal attacks moreover single state required protocol hope helpful research design aqs protocols future
national study exercise related morbidity erm england wales carried using postal questionnaire sent adults aged years questionnaire asked regular participation sports recreational fitness activities involving physical exercise details injuries occurring reference period return rate achieved comparisons national data sources indicated information obtained reliable estimated year million incidents resulting new recurrent injuries however minor million confidence interval million result new substantive injuries potentially serious result treatment participants unable take part usual activities soccer accounted ail erm risk substantive injury rugby three times soccer one third err occurred men aged years frequently reported injuries sprains strains lower limbs treatment sought approximately erm incidents new erm incidents involved tendance hospital accident emergency department treatment provider likely consulted general practitioner physiotherapists complementary medicine practitioners also consulted frequently maximize health benefits exercise research strategies reduce volume severity erm identify appropriate ways managing erm set
human intestinal microbiome important metabolic immunological functions host part defense pathogens gastrointestinal tract antibiotics probiotics dietary measures prebiotics relatively newly established method fecal microbiota transplantation fmt also known fecal microbiome transfer influence intestinal microbiome fmt procedure comprises transmission fecal microorganisms healthy donor gastrointestinal tract patient aim intervention restore normal microbiome patients diseases associated dysbiosis indication fmt currently multiple recurrence clostridium difficile infections approximately affected patients successfully treated fmt compared treated conventionally vancomycin possible therapeutic applications chronic inflammatory functional bowel diseases insulin resistance morbid obesity evaluated clinical trials knowledge optimal donor best dosage appropriate route administration still limited careful donor selection necessary implementation fmt germany subject medicines act arzneimittelgesetz amg duty disclosure personal implementation attending physician documentation central register long term effects side effects fmt evaluated
agenesis corpus callosum model disease disrupted connectivity human brain pathological formation interhemispheric fibers results subtle severe cognitive deficits postnatal studies suggest characteristic abnormal pathways pathology compensatory structures emerge via neural plasticity challenge hypothesis assume globally different network organization structural interconnections already fetal acallosal brain twenty fetuses isolated corpus callosum agenesis without associated malformations enrolled fiber connectivity among brain regions assessed using utero diffusion tensor imaging streamline tractography macroscopic scale connectomes compared gestational age matched normally developing fetuses multiple granularity network analysis gradually increasing connectivity strength tract diffusion anisotropy gestation dominant antero posteriorly running paramedian antero laterally running aberrant pathways short range connections temporoparietal regions fetuses associated abnormalities diffuse reduction cortico cortical cortico subcortical connectivity observed cases isolated callosal agenesis global organization anatomical networks consisted less segregated nodes acallosal brains hubs dense connectivity thalamus cingulate cortex showed reduced network centrality acallosal fetal brains show globally altered connectivity network structure compared normals besides previously described probst sigmoid bundles revealed prenatally differently organized macroconnectome dominated increased connectivity findings provide evidence abnormal pathways already present early stages fetal brain development majority cerebral white matter elsevier inc rights reserved
background adherence pharmacotherapeutic treatment guidelines patients heart failure major prognostic importance thorough implementation guidelines routine care remains insufficient aim investigate prevalence characteristics patients coronary heart disease chd assess adherence current guidelines patients stage thus identifying potential targets optimization guideline implementation methods patients german sample european action secondary primary prevention intervention reduce events euroaspire survey hospitalization chd within previous six months providing valid data echocardiography well signs symptoms categorized stages prevalence risk factors developing asymptomatic structural heart disease symptomatic guideline adherence indicator gai calculated patients reduced left ventricular ejection fraction hfref number drugs taken per number drugs indicated beta blockers angiotensin converting enzyme inhibitors angiotensin receptor blockers mineralocorticoid receptor antagonists mra considered results patients entered analysis stage prevalent stage stage patients patients diagnosed hfref stage patients older longer duration chd higher prevalence arterial hypertension awareness pre diagnosed low overall gai hfref patients trend towards lower gai patients lower lvef due less thorough mra prescription conclusions sample chd patients prevalence stage high sizable subgroup suffered hfref overall pharmacotherapy fairly well implemented hfref patients although somewhat worse patients reduced ejection fraction two major targets identified possibly suited improve implementation guidelines increase patients awareness diagnosis importance disseminate knowledge importance appropriately implementing use mineralocorticoid receptor antagonists
years restorative benefits natural environment taken seriously restorative effects continue verified research psychological physiological perspectives latest functional magnetic resonance imaging fmri technology provides opportunity explore psychophysiological aspects benefits natural environment study aimed compare restorative value four types landscape environments urban mountain forest water questionnaires investigating relationship different environments brain region activity means fmri based one way analysis variance significant difference found restorative value urban natural environments value water mountain environments least urban environment support psychological result brain found respond similarly showing increased activity visual attentional focus areas urban environment viewed opposed natural environment findings reveal new approach test restorative value environment support restorative effect natural environment authors published elsevier
purpose evaluate frequency loss neurophysiological potentials head positioning usefulness head repositioning restore potentials effect neurological outcome methods retrospectively reviewed consecutive cervical spine surgeries performed israel spine center assuta medical center surgeries performed neuromonitoring transcranial electric motor evoked potentials somatosensory evoked potentials electromyographic recordings included demographic data medical history findings neurological examination imaging electrophysiological data recorded surgery neurological outcomes collected analyzed results three hundred eighty one patients met inclusion criteria loss potentials detected nine patients patient positioning repositioning undertaken aim restoring electrophysiological signals patients repositioning resulted immediate reappearance potentials potentials affected decompression repositioning immediately restore electrophysiological signals potentials reappeared later decompression potentials recovered till conclusion surgery new neurological deficits including one patient loss potential restored repositioning one potential restored lost decompression conclusions intraoperative neuro monitoring efficient tool alert surgical team potential neurological damage head reposition often restores electrophysiological signals possible prevention impending sequelae
eigen filters attenuation response adapted clutter statistics color flow imaging cfi shown improved flow detection sensitivity presence tissue motion nevertheless practical adoption clinical use straightforward due high computational cost solving eigendecompositions provide pedagogical description real time computing framework eigen based clutter filtering developed single instruction multiple data simd computing approach implemented graphical processing unit gpu emphasis placed single ensemble based eigen filtering approach hankel singular value decomposition since algorithmically compatible gpu based simd computing key algebraic principles corresponding simd algorithm explained annotations algorithm rationally implemented gpu presented real time efficacy framework experimentally investigated single gpu device gtx titan computing throughput varying scan depths slow time ensemble lengths studied using eigen processing framework real time video range throughput frames attained cfi frames full view azimuth direction scanlines scan depth lambda pixel axial spacing slow time ensemble length samples corresponding cfi image frames respect ones derived non adaptive polynomial regression clutter filtering yielded enhanced flow detection sensitivity vivo demonstrated carotid imaging case example findings indicate gpu enabled eigen based clutter filtering improve cfi flow detection performance real time
proliferation large number images made necessary develop systems indexing organizing images easy access made content based image retrieval cbir important area research computer vision paper proposes combination features multiresolution analysis framework image retrieval work concept multiresolution analysis exploited use wavelet transform paper combines local binary pattern lbp legendre moments multiple resolutions wavelet decomposition image first lbp codes discrete wavelet transform dwt coefficients images computed extract texture feature image legendre moments lbp codes computed extract shape feature texture feature constructing feature vectors feature vectors used search retrieve visually similar images large database proposed method tested five benchmark datasets namely corel olivia corel corel ghim performance proposed method measured terms precision recall expetimental results demonstrate proposed method outperforms state art methods terms precision recall elsevier inc rights reserved
software defect prediction automatically predict defect prone software modules efficient software test software engineering previous defect labels modules limited predicting defect prone modules becomes challenging problem static software defect prediction exist similarity among software modules software module approximated sparse representation part software modules class imbalance problem number defect free modules much larger defective ones paper propose use graph based semi supervised learning technique predict software defect using laplacian score sampling strategy labeled defect free modules construct class balance labeled training dataset firstly use nonnegative sparse algorithm compute nonnegative sparse weights relationship graph serve clustering indicators lastly nonnegative sparse graph use label propagation algorithm iteratively predict labels unlabeled software modules thus propose nonnegative sparse graph based label propagation approach software defect classification prediction uses labeled data also abundant unlabeled ones improve generalization capability vary size labeled software modules datasets widely used nasa projects experimental results show nsglp outperforms several representative state art semi supervised software defect prediction methods fully exploit characteristics static code metrics improve generalization capability software defect prediction model
background invasive wound mucormycosis iwm associated extremely poor outcome among critically ill burn patients describe detection circulating mucorales dna cmdna early diagnosis iwm patients report potential value detecting cmdna treatment guidance methods severely ill burn patients admitted tertiary referral center october february included retrospective plasma samples tested presence cmdna quantitative real time polymerase chain reaction qpcr patients prospectively screened twice week liposomal amphotericin therapy initiated based positive qpcr primary endpoint time cmdna detection standard diagnosis secondary endpoints time cmdna detection treatment initiation mortality results seventy seven patients samples included average age years abbreviated burn severity index simplified acute physiology score total body surface area cmdna detected days standard diagnosis hospital mortality patients iwm without mortality due iwm period period conclusions study suggests detection cmdna allows earlier diagnosis iwm severely ill burn patients earlier initiation treatment studies needed confirm impact earlier treatment initiation patient outcome
background earlier age menopause widely considered associated increased risk cardiovascular disease however underlying mechanisms relationship remain undetermined indications suggest anti mullerian hormone amh ovarian reserve marker plays physiological role outside reproductive system therefore investigated whether longitudinal amh decline trajectories associated increased risk cardiovascular disease cvd occurrence methods study included female participants years age baseline population based doetinchem cohort participants completed consecutive quinquennial visits resulting total follow time years amh measured stored plasma samples information total cvd stroke coronary heart disease obtained hospital discharge registry linkage association amh trajectories cvd quantified joint modeling adjustment age smoking oral contraceptive use body mass index menopausal status postmenopausal hormone therapy use diastolic blood pressure total cholesterol high density lipoprotein cholesterol glucose levels results end follow women suffered cvd suffered coronary heart disease experienced stroke adjustment lower log amh level associated higher risk cvd hazard ratio confidence interval higher risk coronary heart disease hazard ratio confidence interval additional year decrease log amh associated significantly higher risk cvd hazard ratio confidence interval coronary heart disease hazard ratio confidence interval association amh stroke found conclusions results indicate amh trajectories women independently associated cvd risk therefore postulate decline circulating amh levels may part pathophysiology increased cardiovascular risk earlier menopause confirmation association elucidation underlying mechanisms needed place results clinical perspective
abundant diverse set commensal microbial communities covers body surfaces collectively called microbiome functional impact various immune processes modulates many health related processes including autoimmunity active site microorganism host interplay intestinal mucosa growing evidence helped learn specific microbiota composition functionality determine intestinal barrier function furthermore modulate pro inflammatory anti inflammatory immune mechanisms remote organs addition microbial composition skin important functionality skin barrier autoimmune skin diseases review importance microbiome local systemic immune system disturbed microbiome host interaction affect development progression autoimmune diseases understanding associations help unravel new diagnostic therapeutic approaches diseases
generator relaxation oscillations unijunction transistor investigated basis generator rectangular impulses designed manufactured used work fast charging capacitor studying free oscillations rlc circuit measurements parameters contour carried means additional high frequency detector devices generator ahp oscilloscope tdsb quality amplitude frequency characteristics measured technical results conducted researches new laboratory installation study oscillatory processes electrical circuits generator rectangular impulses unijunction transistor
introduction embryology biological science studies prenatal development organisms interest clarify gross anatomy explain develop normal abnormal structures congenital malformations purpose paper describes macroscopic radiographic morphology found malformed fetuses materials methods laboratory experimental embryology malformed fetuses studied footage photographed kodak film radiographic speed size kodak speed film size radiation generating device used exposure time seconds object focus distance fixed anode tube radiogenic fluids used process kodak film method visual results based macroscopic observation identified fetal omphalocele acraneo rachischisis almost complete bony bump neck absence parietal occipital lumbar vertebral arches eyes retracted found radiographically normal process calcification upper lower limbs vertebrae ribs skull delayed calcification abnormal looking skull another macroscopic observation revealed fetal anencephaly spina bifida rachischisis radiographically signs calcification conclusions macroscopic identification allowed classify type malformations radiographic imaging features ossification found altered fetuses knowledge normal development causes congenital malformations necessary incorporate preventive measures allow embryo fetus achieve normal development
search engines based bivalent logic probability theory lack real world conceptual knowledge higher precision reasoning ability ranked links snippets less effective big data analysis web information state art search engine google endeavor retrieve good quality document msn engine bing endeavor decision boosting advanced algorithms account user intents semantics societal patterns web recommendation system product recommendation engines search engines advanced text based voice based dialogue based image based multimedia input question search major advancement analysis search engine enhancement search engines advanced traditional data base retrieval machine web based machines horizontal engines vertical engines naukari com quickr com dedicated crawler technology heart information web structured instructed posses huge challenge big data analytics though retrieval results optimistic yet lack ability interpret user question precise answering relevant informatics search engine enhancement time complexity memory algorithmic machine design parameters support optimized search result question answering search engine engine machine deductive reasoning capability ability amalgamate information various knowledge datasets engine front linear area advanced information retrieval techniques state art technology future search engines expert systems search engines advanced shallow technique keyword technique template based structured knowledge processing engines profile based engines context based machines cross language machines multimedia engines community based yahoo answer stack overflow specialized search engines like ask com qura com true knowledge question answering system embedded google search engine google question answering ibm watson cognitive machine thinking machine like humans decision support engine developed deep project advanced natural language processing information retrieval deep mining machine learning model learns time reasoning model base advent android platform web based services like apple siri android assistant questioner technology art assists enhancement future search engines analysis thinking cognitive ability manuscript present architecture question answering search engine search engine enhancement finite state machine facilitate answering question time complexity abstract methodology algorithmic analysis research paper facilitate future research integration proposed architecture question answering search engine
objective assess systematically effects antidepressants untreated maternal depression human placenta developing fetus methods pertinent medical literature information identified using medline pubmed scopus embase electronic searches limited human studies published english provided studies reporting primary data placental fetal effects antidepressant exposure untreated gestational depression results impact antidepressants non medicated maternal depression placental functioning fetal biochemical architecture seems demonstrated although clinical significance remains unclear robust data seem indicate exposure either antidepressants untreated maternal depression may induce epigenetic changes interfere physiological fetal behavior two cases iatrogenic fetal tachyarrhythmia also reported conclusions future research clarify clinical relevance impact antidepressant untreated maternal depression exposure placental functioning moreover ultrasound studies investigating fetal responses antidepressants maternal depressive symptoms mandatory assessment performed whole duration gestational period different fetal behavioral patterns become progressively detectable analyses biochemical epigenetic modifications associated maternal mood symptoms antidepressant treatment also implemented
important steps prenatal development bovine uterus described using conventional hematoxylineosin staining fetuses different developmental stages crown rump length crl additionally number intermediate filaments keratin vimentin basement membrane protein laminin smooth muscle marker sma studied characterize certain differentiation processes early development uterine epithelium simple pseudo stratified bud like protrusions developing caruncles observed corpus uteri crl onwards showing simple keratin positive epithelium contrast intercaruncular areas characterized pseudo stratified epithelium also shows positive staining different manner investigated keratins differentiation smooth muscle cell layers observed crl onwards intense sma positive cells fibers arranged perpendicularly developing circular sma positive muscle cell layer found preferentially located developing caruncles lymphocytes occur uterine epithelium stroma corpora cornua fetuses clr higher karger basel
safety critical applications five phase fault tolerant permanent machines attracting attentions paper synthesis magnetomotive force mmf produced windings five phase machine analyzed firstly method eliminate mutual inductance fault tolerant machines proposed approach pole slot combination selection five phase fault tolerant machine low mutual inductance given five phase fault tolerant wheel permanent machine designed according requirements electric vehicle application basic dimensions machine derived analytic machine design method finally finite element model designed machine built method machine parameter optimization proposed help finite element model waveform load back emf output torque fault tolerant capacity taken account optimization improves performance machine
aim research examine hiv risk factors affecting poor health ethiopia epidemiological perspectives demographic health survey secondary data used ethiopian population growth slowed dramatically stopped due hiv aids logistic regression correlation hiv positive towards aids high risk factors leading exposure hiv infection adopted selected variables study confirmed high level hiv positivity poor health highly affected socio economic demographic factors
paper first reviews potential causality biomass energy emissions economic development within relevant literature later paper examines statistically impacts biomass energy consumption emissions gdp end paper observes environmental economic implications biomass fuel usage throughout energy literature launches asymmetric causality test confirm disconfirm literature output findings tests indicate biomass energy consumption per capita mitigates emissions per capita increases gdp per capita eventually upon output research asserts biomass energy consumption efficient policy tool environmentally sustainable development hence biomass production technologies biomass consumption need promoted countries well hand analyses underline fact policy makers consider well potential constraints biomass energy usage land use constraints carbon leakage biomass production therefore although paper explores remedial impact biomass environment growth one may suggest also possible works consider effects biomass sources detail minimize worsening influence biomass usage climate change
differentiation psoriatic arthritis psa sine psoriasis rheumatoid arthritis may challenge especially early stages hence need new instrumental markers assist diagnosis study investigated possible dermoscopic differences vascular appearance nail fold elbow classic site repeated trauma two conditions fifteen patients psa sine psoriasis patients controls included study regarding nail fold vascular appearance psa sine psoriasis cohorts presence diffuse reddish background without sparse dotted vessels significant former whereas evidence parallel dotted short linear vessels fish school like pattern irregular ramified blurry purple vessels significant latter none patterns detected control group regarding elbow pattern significantly associated psa sine psoriasis consisted diffusely distributed red dotted vessels hand patients controls displayed similar dermoscopic findings three possible vascular patterns observed irregular blurry purple vessels avascular appearance iii sparse dotted purple vessels conclusion dermoscopy may useful supportive tool differentiating early psa sine psoriasis
background unusual men years age serum testosterone levels lower limits younger men prompting diagnosis hypogonadism study evaluated safety efficacy pharmacokinetics oral enclomiphene citrate alternative currently available androgen replacement therapies methods fifty two subjects randomized oral enclomiphene citrate topical testosterone gel oral placebo daily days pharmacodynamic profiles total testosterone obtained day day dosing subjects assessed follow visit days final dose additional subjects rescreened added dose cohort results days significant dose dependent rise across doses enclomiphene citrate topical testosterone placebo supraphysiologic levels observed topical testosterone treated subjects whereas levels maintained within desirable range enclomiphene citrate treated subjects enclomiphene citrate doses topical testosterone treatment elevated free testosterone levels day compared day placebo topical testosterone associated disproportionate increase dihydrotestosterone dht relative enclomiphene citrate resulted modest decrease enclomiphene citrate rapidly absorbed elimination half life hours non dose dependent steady state level maximal dose effects enclomiphene citrate sustained daily dosing conclusions enclomiphene citrate increased total free testosterone without increasing dht disproportionately changes luteinizing hormone follicle stimulating hormone dht ratio enclomiphene citrate suggest normalizes endogenous testosterone production pathways restores normal testosterone levels men secondary hypogonadism within days
background objectives psychosocial factors gender role norms may impact social anxiety disorder sad experienced expressed different social contexts women however date factors examined via experimental methodology design cross sectional quasi experimental controlled study methods current study included highly socially anxious hsa women meeting criteria sad examined relationships among psychosocial factors gender role self discrepancies self perceived physical attractiveness self perceived social performance state anxiety across two vivo social tasks conversation opinion speech results average participants reported belief ought less feminine speech task masculine conversation speech tasks also conversation task lower self rated attractiveness predicted poorer self perceived performance greater post task state anxiety gender role self discrepancies confederate gender speech task greater self discrepancy prototypical masculine traits predicted poorer performance ratings related greater state anxiety anticipation task conclusion hsa women psychosocial factors may play different roles social anxiety across social contexts
paper proposed universal method implementing ptp precision time protocol test systems ethernet interface achieve synchronization accuracy sub microsecond configurable real time clock time stamp module realized programmable logic makes phy mac free time stamp functions communication link ptpd precision time protocol deamon open source implementation modified transplanted embedded linux system realize ptp state machine ieee core device driver developed provide application layer access accurate time stamp obtained link layer ieee core project structure makes transplantation process concentrate time adjustment algorithm design application layer regardless obtaining precise time stamp hardware proposed method evaluated xilinx zynq soc platform outputting pps pulse per second verify synchronization accuracy nodes master slaves network quantifying accuracy stability synchronization offset concluded clock frequency offset network transmission delay main influence factors synchronization proved feasibility maintaining submicrosecond level synchronization accuracy within multi level switch topology
quantitatively analyzed dendritic dendritic spine development basal oblique dendrites large layer iiic pyramidal neurons prospective prefrontal area brains three infants syndrome five age matched controls period weeks postconception postnatal month using neurolucida software rapid golgi impregnated slices neurons three dimensionally reconstructed significant differences pattern dendritic spine development basal apical oblique dendrites subjects depart significantly developmental curve control subjects data showed large significant segment outgrowth parallel dendritic elongation occurred limited period time weeks postconception first postnatal month dendritic spines appeared time birth density continued increase age months first postnatal month long thin spines filopodia like protrusions predominated spines later changed morphology mature form differences spine morphology qualitatively observed infants age matched controls data suggests intensive formation cortical circuitry occurs large layer iiic pyramidal neurons perinatal period disturbed infants consequently could biological potential mitigate psychomotor impairment patient
trilayer bending actuators charge driven devices ability function air provide large mechanical amplification electronic mechanical properties actuators known functions charge state making prediction responses difficult operate full range deformation work combination state space representation two dimensional transmission line model used implement nonlinear time variant model conducting polymer based trilayer actuators electrical conductivity young modulus electromechanically active pedot conducting polymer containing films function applied voltage measured incorporated model drop young modulus times increase conductivity observed oxidizing pedot closed form formulation radius curvature trilayer actuators considering asymmetric location dependent young modulus conductivity conducting polymer layers derived implemented model nonlinear model shows capability predict radius curvature function time position reasonable consistency within formulation useful general trilayer configurations calculate radius curvature function time proposed electrochemical modeling approach may also useful modeling energy storage devices
availability safe drinking water considered key challenge coastal region bangladesh high concentrations salinity iron arsenic unavailability suitable aquifers deterred exploitation groundwater resources addition cyclonic storm surge major threat system cyclones accompanied storm surges coastal area cause significant deterioration drinking water supply sanitation water professionals launched initiatives promote small scale alternative safe water sources rainwater harvesting pond sand filters piped water techniques provide sustainable solutions problem however systematic evaluation alternatives considers social technical economic criteria carried far present study attempt evaluate alternative options drinking water supply cyclone prone area authors conducted multi criteria analysis reached conclusion rainwater harvesting suitable option area moreover final result shared users obtain feedback ensure sustainability water source
characterize different types conflicts often occur complex distributed multi agent scenarios ambient intelligence ami environments argue conflicts resolved suitable order using appropriate conflict resolution strategies individual conflict type analysis shows conflict resolution ami environments similar multi agent domains complex process spanning different levels abstraction agents deployed environments need handle conflicts coordination certain level agreement consecutively point problem currently handled relevant ami literature
introduction relationship perception focuses social interactions reduced schizophrenia related daily functioning assessed relationships across domains rad test built relational models theory states people use four relational models interpret social interaction rad time consuming low tolerability used english speaking countries evaluated psychometric properties translated abbreviated norwegian version methods sixty two schizophrenia participants healthy controls underwent assessments social non social cognition schizophrenia group completed functional clinical measures rad internal consistency investigated cronbach alphas group differences logistic regressions associations study variables pearson correlations results rad reduced cronbach alpha vignettes cronbach alpha schizophrenia participants significant impairments larger effect sizes full version associations rad study variables similar two versions smaller clinical measures larger functional cognitive measures results comparable results english version conclusions length norwegian rad reduced retaining psychometric properties similar english version suggests test cross cultural utility
objective cross sectional studies elevated body mass index bmi associated cognitive impairment bipolar disorder investigated direction association prospectively examining changes bmi cognition method measured bmi performance six cognitive domains months adolescent young adult patients healthy comparison subjects ninety three percent patients received pharmacotherapy euthymic used repeatedmeasures ancova longitudinal mixed models investigate whether higher bmi increasing bmi time predicted lower subsequent cognitive functioning lower cognitive functioning changes cognition predicted increasing bmi results neither baseline bmi bmi change predicted lower cognitive functioning lower baseline scores attention verbal memory working memory composite measure global cognition predicted increasing bmi patients patients lower cognitive functioning remained associated increasing bmi clinical treatment variables adjusted improvement working memory predicted smaller subsequent bmi increase patients conclusion lower cognitive functioning specific domains predicts increasing bmi patients healthy young adults targeting cognition may important minimizing weight gain
kaizen refers philosophy practices focus upon continuous improvement processes manufacturing engineering business management improvements usually accomplished little expense without sophisticated techniques purpose paper present results implementing kaizen principles port installed options center toyota saudi arabia using relevant kaizen tools including toyota production system tps seven muda enabled understand system identify critical problem areas kaizen target set analyzing problems identifying gap existing system tps main results study summarized using facilities possible efficient reducing manpower needed installers effective increasing annual output vehicles improve associates engagement index potential inventory reduction due use kanban system time production avoid investing new facilities needed meet increase demand market resulted improving production line productivity appreciated acknowledged toyota motor corporation
mania core criterion bipolar disorder chronic severe psychiatric illness centrally associated positive affective disturbance many self report measures created assess symptoms risk mania notable disparities length scope content thus goal study determine structure correlates number widely used bipolar relevant measures hypomanic personality scale altman self rating mania scale general behavior inventory mood disorder questionnaire data community sample study student sample assessed two time points study respectively provided strong evidence measures characterized well defined common dimension single factor extracted clear structure emotional lability activated positive affect upon extracting two factors general factor showed relatively nonspecific pattern associations personality psychopathology contrast emotional lability factor showed strongest relations neuroticism depressive symptoms displaying comparatively weaker relations measures extraversion positive emotionality conversely although activated positive affect also associated positively depressive symptoms neuroticism instances strongest relations measures extraversion high arousal positive emotionality findings suggest measures defining emotional lability seem assess mood volatility greater extent whereas measures defining activated positive affect factor capture intense high arousal form positive emotionality
rarely explored subject animal research effect pre injury variables behavioral outcome post sci low reporting variables may underlie discrepancies findings laboratories particularly intensive task specific training sci might important considering sports injuries one leading causes sci thus individuals sci often underwent rigorous training injuries present study asked whether training sci grasping task swimming task would influence motor recovery rats swim pre training impaired recovery swimming weeks post injury result fits idea motor learning interference posits learning something new may disrupt learning new task case learning strategies compensate functional loss sci contrast swimming grasp pre training influence grasping ability sci time point however grasp pre trained rats attempted grasp times untrained rats first weeks post injury also lesion volume grasp pre trained rats greater untrained rats finding may related stress activity increased participation rehabilitative training pre trained rats early weeks post injury may potentiated spontaneous plasticity spinal cord counteracted deleterious effect interference bigger lesions thus findings suggest pre training plays significant role recovery cns damage needs carefully controlled elsevier rights reserved
backgroundthis analysis aimed assess incidence regression correlated factors nonalcoholic fatty liver disease nafld type diabetes poorly known methodsnonalcoholic fatty liver disease defined fatty liver index fli score patients type diabetes related factors investigated nationwide database containing information italian network diabetes clinics variation fli cut considered analyses cohort patients separately conducted developed maintained recovered fli assessed nafld fli nafld year period resultsat baseline fli nafld diagnosed patients within year study period fli nafld occurred patients remitted fli score remained unchanged body mass index odds ratio confidence interval abdominal obesity low hdl cholesterol levels triglycerides emerged notable negative prognostic factors development maintenance fli nafld regression rate fli nafld higher among patients managed partially control factors male sex established organ damage especially kidney function independent risk predictors unlike diabetes complications fli nafld frequent among younger patients shorter duration diabetes conclusionsfli assessed nafld dynamic condition diabetic patients entering leaving status every year younger male patients insulin resistance organ damage higher risk presenting fli nafld baseline developing fli nafld within years lower probability regression
explored socialization goals african american latino chinese white mothers held adolescents within domains centrally relevant adolescence proper demeanor academics race ethnicity peers method card sort task subsequent logistic regression analyses used explore mothers choice important socialization goals ethnically racially diverse grade adolescents results compared white mothers african american latino chinese mothers significantly likely select proper demeanor goals emphasize deference benevolence peer goals emphasize instrumental relational friendships african american latino mothers likely select race ethnicity goals emphasize cultural egalitarian goals compared chinese white mothers mothers likely select academic engagement important performance contrast mothers emphases within domains mothers ranked importance different domains remarkably similarly conclusions mothers socialization goals illustrate similarities differences across race ethnicity findings discussed reference mothers goals reflect broad cultural orientations well contextual demands adolescents experiences
understanding dynamics lead restriction human rights social psychology research mainly focused concept banality evil obedience destructive immoral orders however authors also underlined relevant role standing general indifference supporting authoritarian policies par obedience authority aim research study notion intergroup indifference defined uninterested problems affecting social groups hypothesis indifferent people characterized subtle modalities obedience authority prejudicial attitudes exclusive attitudes conformist traditional positions results showed participants respond indifferent stance parliamentary bills related arbitrary policies towards minorities appear characterized similar scores subtle prejudice submission authority conventionalism willingness protest conservative values moral exclusion attitudes people openly support policies instead two groups differ concerns overt hostile attitudes data suggest indifferent people role supporting arbitrary policies theoretical implication future research consider intergroup dynamics involve people obey disobey authority people apparently take stance authority policies considered well
objectives despite recent increase hiv aids epidemic among young people china youth specific hiv data limited methods total individuals hiv aids aged years registered case reporting system china complete spatial information included present analysis spatial autocorrelation general local space time scanning performed using arcgis satscan software respectively results number reported hiv aids cases proportion hiv cases increased proportion aids cases decreased sexual contact became predominant route transmission later years spatial analysis showed marked geographical variations hiv infection among young people throughout china number new hotspots increased time mainly localized southeastern coastal areas southwestern frontier provinces autonomous regions guangxi yunnan sichuan beijing municipality later hotspots disappeared new hotspots found northeast country significant clusters hiv positive cases identified three different time periods indicated high hiv transmission among young chinese people recent past risk hiv infection highest first cluster cluster largest size covering provinces guizhou yunnan chongqing municipality guangxi province sichuan second cluster mostly located shanghai south jiangsu zhejiang south anhui third cluster located beijing tianjin conclusions target specific comprehensive behavioural interventions urgently needed contain hiv epidemic among young people
background bipolar patients show high intra individual variability cognitive processing however known whether specific fluctuations variability contributing overall high cognitive inconsistency objective compare dynamic profiles patients healthy controls identify hypothetical differences associations overall variability processing speed methods changes reaction times isd processing speed test performance time measured dividing isd whole task four consecutive parts motor speed cognitive effort controlled results patients exhibited significantly lower results regarding processing speed higher intraindividual variability comparing profile intra individual variability changes time performance significantly different versus groups eta rho isd patients initial phase performance three times higher last significant differences four intervals group inter group difference initial part profiles significant also controlling several cognitive clinical variables limitations applied computer version cognitive speed test relatively new thus replication studies needed effect seen present study driven mainly type conclusions patients exhibits problems setting stimulus response association starting phase cognitive processing deficit may negatively interfere cognitive functions decreasing level psychosocial functioning therefore explored future studies
goal study examine waste water leather plants within province usak city conducted analyses morning evening hours summer following greater eid volume waste water usak leather organized industry low high respectively analyses carried using waste water different sections facility waste water analysis conducted using waste water treatment center entrance chemical treatment using waste water subjected biological treatment waste water exiting facility suspended solid matter chemical oxygen requirement color total nitrogen phosphate phosphorus total chrome turbidity grease content waste water sections analyzed comparing waste water exiting entering facility based discharge standards stated water pollution control regulations determined facility enabled lower numbers pollution low high intensity periods values lower compared facility entrance chemical biological treatment result evident treatment facilities necessary protecting natural water resources health negative effects leather industry facility minimizes effect leather industry waste nature thereby preventing disruption ecosystem
wear resistance important rubber compound property related useful product life rubber compound properties affect wear behavior complicated wear related rubber compound cut resistance tear resistance fatigue resistance hardness etc commonly used test method determine wear resistance rubber materials abrasion test tested compounds usually compared volume loss basis calculated weight loss density compound method known variable give additional information wear behavior reason propose alternative approaches examination wear behavior rubber composites giving information wear resistance also elastic modulus stiffness material damage mechanism etc continuous multi cycle indentation used determine indentation hardness elastic modulus stiffness two indenter types vickers sphero conical comparison results made order investigate effect indenter type
aimmifepristone synthetic steroid compound induces abortion recently found potentially pass human milk study aimed determine effects mifepristone administration lactating mice development reproduction progeny methodslactating mice gavage fed mifepristone daily days either days days lactation controls received peanut oil growth mortality rate organ weight bodyweight ratio sex hormone days fertility progeny litter size sex ratio mortality rate second generation recorded resultsno significant differences observed average bodyweight mortality rate female male pups organ coefficient uterus ovaries females adulthood comparison controls however organ coefficient testis day testosterone concentration day increased male pups moreover reproductive capacity pups unaffected days exposure mifepristone via mother milk time birth pups litter size sex ratio mortality rate similar control pups conclusionthe study showed treating lactating mice mifepristone influenced organ coefficient testis day testosterone concentration male pups day however affect development fertility female male pups
better understand fundamental interactions melt jet coolant core disruptive accident sodium cooled fast reactor jet breakup droplet formation immiscible liquid liquid systems studied experimentally experiments using two different pairs test fluids carried isothermal conditions observed jet breakup behavior classified characteristic regimes based classical ohnesorge classification liquid gas systems variation breakup length obtained present liquid liquid system similar liquid gas system droplet size distribution breakup regime analyzed using image processing droplet formation via pinch satellite formation entrainment observed measured droplet size compared available melt jet experiments based observation analysis results breakup regimes organized dimensionless operating diagram derived correlations representing criteria regime boundaries liquid liquid system finally experimental data extrapolated expected conditions sodium cooled fast reactor implied hydrodynamic conditions accident would close atomization regime entrainment dominant process droplet formation elsevier rights reserved
assessment prevention floods require appropriate forecasting knowledge related hydrological processes due similar form governing equations flood hydrograph shows clear analytical mathematical analogy electrical circuits paper spatially distributed hydrological model developed analogue network electrical resistance capacitance five circuits describing hydrological processes leading floods spatially distributed hydrological model simulates rainfall potential evapotranspiration canopy interception surface storage soil storage parameters analogical modelling derived translation physical catchment characteristics two parameter weibull equation aggregates response functions pixel calculates hydrograph catchment applied model open book tilted catchment theoretical benchmark problem well four hourly flood events simulation daily discharges last two cases data used mountainous catchment upper tarqui andes ecuador comparison single versus multiple circuit designs benchmark problem indicates multiple circuit analogy provides result similar hydrological models results illustrate usefulness methodology flood modelling simplify simulation ungauged basins temporal spatial variations influencing hydrological processes
parents increasingly turning online health forums discuss concerns children health seek advice health decisions study examines characteristics elaboration online forum discussions parents rotavirus vaccine establishes types central peripheral message cues parents generated extent elaboration exchanges associated parents decisions children vaccination results indicated forum users employed central peripheral cues joint process generating information intended help parents gain knowledge make vaccination decisions issue relevant arguments important vaccination decision included vaccine necessity side effects efficacy peripheral cues including site generated sorting cues associated posts featuring greater elaboration new parents doubts asking questions vaccine issues elaboration however weakest elsevier ltd rights reserved
convection enhanced delivery ced promising technique generates pressure gradient tip infusion catheter deliver therapeutics directly interstitial spaces central nervous system addresses offers solutions many limitations conventional techniques allowing delivery past blood brain barrier targeted safe manner achieve therapeutic drug concentrations ced broadly applicable technique used deliver variety therapeutic compounds diversity diseases including malignant gliomas parkinson disease alzheimer disease number technological advances made since development early clinical trials ced largely unsuccessful illuminated number parameters still need addressed successful clinical application review addresses physical principles behind ced limitations technique well means overcome limitations clinical trials performed future developments
high test embankment constructed soft foundation improved geotextile encased granular columns gecs embankment construction performed four stages days resulting total applied stress around kpa soft soil encased columns instrumented measure surface settlements excess pore pressure surface vertical stresses radial deformation geotextile encasement stress concentration difference settlement top encased columns soft soil studied results showed differential settlement increased embankment height increased excess pore pressure dissipated due soil arching vertical stress supported encased column two times greater stress transmitted soft soil also vertical stress encased column increased consolidation progressed whereas vary significantly soft soil american society civil engineers
nulliparous pregnant woman mid week gestation presented emergency department severe headache vomiting uneventful medical history however physical examination upon hospital admission revealed hypertensive emergency papilledema dipstick proteinuria upon establishing diagnosis preeclampsia aggressive therapy corticosteroids antihypertensive medication seizure prophylaxis initiated hemodynamic stability achieved within hours patient remained observation unit located within gynecology clinic ninth day postadmission however condition abruptly deteriorated advanced imminent eclampsia accompanied transient vision loss altered mental status acute hypertensive crisis patient underwent successful emergent delivery via caesarean section laboratory workup revealed hemolysis elevated liver enzymes low platelet count suggesting hellp syndrome serious complication eclampsia patient concurrently developed posterior reversible encephalopathy syndrome confirmed magnetic resonance imaging acute respiratory distress syndrome latter presented diffuse bilateral infiltrates ray developing pulmonary edema absence cardiac etiology life threatening dynamics patient transferred intensive care unit treatment case rare cascade life threatening complications developed patient required skillful multidisciplinary decision making experienced management within acute critical care setting final outcome treatment intensive care successful patient child survived chronic debilitating sequelae
evaluate association sleep duration snoring diabetes according gender menopausal status rural china data part baseline survey china kadoorie biobank rural county south east costal zhejiang province participants including men women aged years enrolled multivariable logistic regression used calculate adjusted odds ratios ors confidence intervals cis diabetes sleep duration shown shaped association diabetes women particular postmenopausal women adjustment potential confounders compared sleepers ors cis sleep duration diabetes respectively postmenopausal women quadratic trend however shaped association obvious men premenopausal women frequently snoring positively associated diabetes participants however association independent socioeconomic status health behaviors obesity chronic diseases increasing sleep duration proportion frequently snoring increased participants trend postmenopausal women higher odds diabetes compared premenopausal women duration menopause cumulative effects diabetes short long sleep durations significantly associated diabetes postmenopausal women independent potential confounders proportion frequently snoring linear trend sleep duration postmenopausal status duration menopause increased odds diabetes
introduction aids study group grupo estudio del sida gesida developed quality care indicators aim study determine indicators associated mortality hospital admission perform preliminary assessment prediction rule mortality hospital admission patients treatment follow methods retrospective cohort study conducted hospital universitario son espases palma mallorca spain eligible participants patients human immunodeficiency syndrome years old began follow infectious disease section january december descriptive analysis performed evaluate anthropometric variables logistic regression analysis assess association gesida indicators mortality admission mortality probability model built using logistic regression results total adults eligible median age years old male multivariate analysis quality care indicators associated mortality follow patient group items group patients treatment quality care indicators associated hospital admissions follow patients group mortality analysis plus number treatment group associated quality care indicators items conclusions gesida quality care indicators associated mortality hospital admissions indicators associated delayed diagnosis regular monitoring prevention infections control comorbidities elsevier espana sociedad espanola enfermedades infecciosas microbiologia clinica rights reserved
previous work indicated hmgb pro inflammatory cytokine closely associated pathogenesis psoriasis clarify role hmgb pathogenesis psoriasis investigated direct function hmgb application hmgb blockade imiquimod imq induced psoriatic mouse model study mice treated imiquimod imq induce psoriasis like inflammation consecutively injected recombinant hmgb phosphate buffered saline pbs abundant cytoplasmic expression hmgb observed lesional skin imq treated skin injection hmgb imq treated skin aggravated psoriasis like disease enhanced infiltration cells myeloperoxidase neutrophils cdc dendritic cells increased number cells upregulated mrna expression interleukin tumor necrosis factor tnf interferon ifn compared pbs injection finally using anti hmgb monoclonal antibody hmgb inhibitor glycyrrhizin indicated hmgb blockade reduced number cells suppressed mrna expression tnf ifn moderated clinical histological evolvement imq treated skin data suggest hmgb may act pro inflammatory cytokine contribute development imq induced psoriasis like inflammation hmgb blockade may represent new direction suppression psoriasis
deficiencies cathode materials severely limit cycling performance discharge rates batteries key problem cathode materials must combine multiple properties high lithium ion intercalation capacity electrical ionic conductivity porosity mechanical toughness materials revealed promising characteristics subset properties attaining entire set often contrarian characteristics requires new methods materials engineering paper report high surface area composite reduced graphene oxide loaded lifepo lfp nanoparticles made layer layer assembly lbl high electrical conductivity lbl composite combined high ionic conductivity toughness low impedance result materials properties reversible lithium storage capacity coulombic efficiency high respectively cycles moreover composites enabled unusually high reversible charge discharge rates storage capacity exceeding known lfp based cathodes several times retaining high content active cathode material study demonstrates lbl assembled composites enable resolution difficult materials engineering tasks
although literature suggests feasible train paraprofessionals effectively implement social interventions students autism spectrum disorders asd paucity research addresses social validity programs present study replicated extended previous research paraprofessional training well assessed social validity results suggest paraprofessionals trained fidelity using package consisting lecture performance feedback collateral gains paraprofessionals following training social interactions students asd typically developing peers improve following paraprofessional training strong social validity regard acceptability training program limitations future directions discussed
superconducting synchronous generators scsgs drawing attention large direct drive wind turbine applications despite low weight compactness short circuit torque scsg may high wind turbine constructions due large magnetic air gap scsg paper aims assessing effects armature winding segmentation reducing short circuit torque scsgs concept armature winding segmentation multiple power electronic converters presented four scsg designs using different topologies examined results show armature winding segmentation effectively reduce short circuit torque four scsg designs one segment shorted terminal
purpose application organic inorganic fertilizers soil result increased gaseous emissions well nitrate leaching contributing climate warming ground surface water pollution particularly regions hot climates high temperatures high soil nitrification rates often occur use nitrification inhibitors nis shown effectively decrease nitrogen losses soil plant system materials methods non disruptive laboratory incubation experiments conducted assess extent temperature degrees nutrient source mineral organic fertilizers influence rate carbon related microbial processes soil response dimethylpyrazole phosphate dmpp furthermore short term changes ability microbes degrade substrates evaluated disruptive soil microcosms using microbial community level physiological profiling abundance bacterial rrna gene measure total bacterial population size results discussion dmpp reduced net nitrification weeks incubation degrees average respectively similar dynamics mineral organic fertilization addition labile organic matter cattle effluent led rapid increase mineralization significantly reduced dmpp temperatures whereas changes could detected addition mineral fertilizer culturable heterotrophic microorganisms showed metabolic diversification oxidation sources organic fertilizer playing major role substrate utilization patterns first week incubation dmpp effects prevailing day day furthermore copy number bacterial rrna gene reduced application dmpp organic fertilizer days conclusions results show marked efficiency dmpp elevated temperatures incubation associated mineral organic fertilization providing support use tool mitigate losses mediterranean ecosystems however also observed impaired respiration rates bacterial abundances well shifts communitylevel physiological profiles soil possibly indicating short term effect dmpp organic fertilizers non target crelated processes microorganisms
neurogut funded initial training network itn research projects neurogastroenterology employed equal number early stage researchers neurogut trainees haveamong activitiesattended international conference irritable bowel syndrome ibs bologna asked critically review evaluate current knowledge ibs respective research activities state missing appreciated topics brain imaging gut activity role gut microbiota pharmacology gut functions ibs ibd interrelation new rome criteria role gas placebo response functional disorders missed detailed coverage high resolution manometry functional brain imaging advanced systems medicine approaches bioinformatics technology better sub classification ibs patients development disease biomarkers extended molecular genetic epigenetic proteonomic level summarize despite excellent specialized research gap open filled systems medicine would necessary medical research learns even data sciences basic disciplines example information technology system biology also welcomes change paradigm enhances open sharing data information resources
renewable source energy wind widely used produce electrical power progress wind turbine technology greatly benefit improvement control algorithms pitch angle control horizontal axis wind turbine rated wind speed challenging issue related nonlinear aerodynamic behavior blades linearization aerodynamic model around nominal operating condition well manufacturing deficiencies result unknown parameter uncertainties wind turbine model therefore performance controller designed based mathematical model defects practice current paper adaptive self tuning regulator str configuration proposed pitch control parameters wind turbine model constantly estimated controller gains updated based assessed parameters str structure consists recursive least square estimator proportional integral derivative pid controller adjustable gains determined pole placement method real time routine robustness closed loop system investigated implementation control structure aero servo elastic wind turbine simulator sake comparison baseline gain scheduling pid controller well accepted wind turbine pitch control designed comparison simulations two controllers confirms significant improvement closed loop performance including less fluctuation rotor speed power besides minor fatigue loads blades main shaft elsevier ltd rights reserved
evolution research network moving target defense mtd selection optimal strategy become one key problems current research directed problem improper defensive strategy selection caused inaccurately characterizing attack defense game mtd optimal strategy selection mtd based markov game proposed balance hopping defensive revenue network service quality one hand traditional matrix game structure often fails describe mtd confrontation accurately deal inaccuracy mtd based constructed markov decision process used characterize transition among network multi states dynamic game used characterize multi phases attack defense inmtdcircumstances besides converts attack defense actions changes attack surface ones exploration surface thus improving universality proposed model hand traditional models care little defense cost process optimal strategy selection comprehensively analyzing impact defense cost defense benefit strategy selection optimal strategy selection algorithm designed prevent deviation selected strategies actual network conditions thus ensuring correctness optimal strategy selection finally simulation deduction proposed approach given case study demonstrate feasibility effectiveness proposed strategy optimal selection approach
useful challenging analyze select object features high resolution vhr remote sensing imagery overwhelming majority existing feature selection methods always concatenate features long feature vector select features vector ignoring homogeneity heterogeneity underlying feature subspaces paper propose supervised multiview feature selection smfs method unlike existing multiview methods smfs requires prior knowledge number views independent prefixed classifier utilizing homogeneity heterogeneity data smfs employs affinity propagation automatically decompose features multiple disjoint meaningful feature groups views without prior knowledge group view consists homogeneous features describing unique data characteristic different views represent heterogeneous data characteristics features evaluated selected based joint norm minimization loss function regularization term different popular norm joint norm enforces intraview sparsity instead interview sparsity consequently view represented representative features view information heterogeneous views well kept remaining representative features experimental results four vhr satellite images attest effectiveness practicability smfs comparison single view algorithms furthermore discussions conducted give insights homogeneity heterogeneity features
precast hollow core slabs hcs technically advanced products precast concrete industry widely used last years due versatility multipurpose potential low cost using three dimensional fem finite element method elements study focuses stresses induced prestressing steel particular investigation spalling crack formation takes place prestressing carried since important assure appropriate necessary margins concerning stresses fact spalling cracks may spread rapidly towards web leading detachment lower part slab parametric study takes place capable evaluating influence tendon position web width spalling stress consequently extensive literature review topic soft computing optimization hcs performed means genetic algorithms coupled fem models
aim paper present experimental validation results show design simplicity single input interval type fuzzy pid fpid controllers evaluating performance real time dof helicopter testbed study briefly show presented analytical design approach gives opportunity construct fuzzy mappings tuning single parameter constructs footprint uncertainty fou fuzzy sets employing theoretical analyses various single input fpid sit fpid controllers designed solve control problem dof helicopter extensive comparative experimental analysis analyze fuzzy control system performances validate effect fou parameter controller characteristics experimental results show neither priori knowledge mathematical model system parameters sit fpid able achieve satisfactory control performance nonlinear working regions presence noise unmodelled disturbance dynamics believe experimental validation sit fpid controllers theoretical analyses open door wider deployment sit fpids real world control engineering applications
two experiments investigated reactive top cognitive control detrimental influence spoken distractors semantically related words presented visually free recall experiment demonstrated increase focal task engagement promoted experimentally reducing perceptual discriminability visual target words eliminated disruption distractors veridical recall also attenuated erroneous recall distractors recall instruction eliminates requirement output monitoring used experiment investigate whether increased task engagement shields distraction change output monitoring processes back end control affecting processing distractors presentation front end control rates erroneous distractor recall much greater experiment erroneous distractor recall disruptive effect distractors veridical recall still attenuated reduced target word discriminability taken together results show task engagement dynamic strategic control modulated shield auditory distraction attenuating distractor processing encoding thereby preventing distractors coming mind test
affective theory mind tom specific ability represent others emotional states feelings previous studies examined affective tom ability patients huntingtons disease using reading mind eyes test rmet results consistent showing difficulties inferring complex mental states photographs people even early stage however agreement whether cognitive impairments population might contributed poor performance rmet test aim present study assess whether affective tom ability impaired mild moderate stages whether association compromised tom ability presence cognitive impairment evaluated tom means rmet global cognitive functioning means moca questionnaire patients healthy subjects groups matched age level education study showed ability judge persons mental states picture eyes impaired patients compared normal population indeed subjects gave correct responses rmet whereas healthy control subjects percentage correct responses furthermore impairment correlated global cognitive functioning except visuospatial task results show rmet might represent valid instrument assess affective tom ability patients mild moderate stages disease independently cognitive status since known patients addition motor symptoms suffer cognitive deficits including memory executive impairments important instrument influenced cognitive abilities possible therefore use rmet assess important aspects patients ability recognize others emotions feelings even patients suffer cognitive decline
graphics processing units gpus increasingly used high performance computing programming frameworks general purpose computing gpus gpgpu cuda opencl also maturing driving trend recent proliferation mobile devices smartphones wearable computers devices increasingly incorporating computationally intensive applications involve form environmental recognition augmented reality voice recognition however devices low computational power satisfy demanding computing requirements cpu load devices could reduced offloading computation onto gpus cloud paper presents gpurpc remote procedure call rpc extension gdev rich set runtime libraries device drivers achieving first class gpu resource management gpurpc allows developers use cuda gpgpu development work existing research uses rpcs based cuda application programming interfaces apis hence cuda apis require communication reduce communication overhead use rpc based low level api cuda api reduced api require communication evaluation conducted linux nvidia gpus shows basic performance prototype implementation reliable comparison existing method evaluation using rodinia benchmark suite designed research heterogeneous parallel computing showed gpurpc effective applications image processing data mining gpurpc also improve power consumption approximately cpu processing performing matrix multiplication
purpose purpose study determine incidence predictors incontinence associated dermatitis iad nursing home residents methods records cohort elderly years newly incontinent nursing home residents nursing homes states free iad followed iad development potential multilevel predictors iad identified national datasets containing information characteristics individual nursing home residents nursing home care environment communities nursing homes located unique set health practitioner orders provided information iad predictors iad prevention pressure injuries extended perineal area analysis based hierarchical logistical regression results incidence iad significant predictors iad receiving preventive interventions iad presence perineal pressure injury greater functional limitations activities daily living perfusion problems lesser cognitive deficits conclusion findings highlight importance prevention iad treatment prevention pressure injuries woc nurse offers expertise interventions educate staff iad predictors improve resident outcomes recommendations include implementing plans care improve functional status treat perfusion problems provide assistance incontinence skin care residents milder well greater cognitive deficits
objectives low testosterone levels related higher diagnosis prostate cancer pca hormonal levels related poor prognosis factors men pca mainly radical prostatectomy aim determine relationship hormonal levels pca prognosis factors men pca prior onset treatment patients methods prospectively analysed males diagnosed centre pca core prostate biopsies february december part clinical protocol performed hormonal determination testosterone sex hormone binding globulin following international society andrology international society study aging male european association urology recommendations free testosterone bioavailable testosterone calculated using vermeulen formula age prostate specific antigen psa free total psa psa density number previous biopsies digital rectal examination staging gleason score percentage tumour biopsy sample bilaterality tumour risk progression group prospectively recorded results higher testosterone levels related lower digital rectal examination staging lower psa level higher testosterone related lower gleason score testosterone inversely related pca bilaterality percentage tumour biopsy high testosterone levels found patients allocated low risk progression group inversely multivariate analysis higher age lower testosterone related higher amico risk progression conclusion patients pca lower testosterone levels poor prognosis factors higher tumour burden treatment onset findings reinforce idea low testosterone levels pretreatment related poor prognosis pca
paper experiments conducted aiming combined investigation hydroelastic structural connectors internal forces response pontoon type modular floating breakwater consisting flexibly connected moored chains modules action perpendicular oblique regular waves regarding hydroelastic response displacements modules wave action video recording horizontal vertical displacements specific points relatively fixed points implemented response determined appropriate image processing procedure asseasing structural response strain rosettes utilized enabling evaluation connectors forces corresponding strains measurements effect incident wave characteristics period height obliquity hydroelastic structural response analyzed correlation connectors forces hydroelastic response extensively discussed hydroelastic structural response depends strongly upon wave period wave height obliquity affect response low frequency range strong dependency connectors forces upon existence intense deformed shape demonstrated
use computers statistical physics common sheer number equations describe behaviour entire system particle particle often makes impossible solve exactly monte carlo methods form particularly important class numerical methods solving problems statistical physics although methods simple principle proper use requires good command statistical mechanics well considerable computational resources aim paper demonstrate usage widely accessible graphics cards personal computers elevate computing power monte carlo simulations orders magnitude thus allowing live classroom demonstration phenomena would otherwise reach example use public goods game square lattice two strategies compete common resources social dilemma situation show second order phase transition absorbing phase system belongs directed percolation universality class compare time needed arrive result means main processor means suitable graphics card parallel computing graphics processing units developed actively last decade point today learning curve entry anything steep familiar programming subject thus ripe inclusion graduate advanced undergraduate curricula hope paper facilitate process realm physics education end provide documented source code easy reproduction presented results development monte carlo simulations similar systems
anxiety depression two common psychological disorders high morbidity worldwide understanding prevalence patients chronic respiratory diseases becoming important clinicians current study aims investigation prevalence potential risk factors anxiety depression among patients chronic respiratory diseases psychological status anxiety depression relevant risk factors patients chronic respiratory diseases general hospitals jiangsu province china evaluated results showed patients chronic respiratory diseases experiencing depression anxiety accounted respectively multivariate logistic regression analysis revealed lower body mass index bmi sleep disorders limitation physical activity negative life events significantly associated increased risk depressive anxiety symptoms poor marital status including divorce separation widowerhood markedly correlated increased risk depression chronic pain anxiety symptoms respectively collectively data demonstrated depression anxiety highly prevalent among patients chronic respiratory diseases greatly significant take specific psychological measures lower incidence depression anxiety patients
using data two measurement networks analyse following aspects wind speeds switzerland assess possibility high wind power penetration spatial correlation persistent low wind power conditions diurnal seasonal wind speed patterns show correlation amongst speeds function distance significantly lower compared values found literature attributed complex terrain alps profound influence meteorological parameters secondly using extreme value analysis calculate return levels low wind power periods large differences found return levels ranging power production return period years clear spatial pattern found account values however length production periods decreases increasing elevation next investigate diurnal seasonal wind speed patterns show different patterns intra annual variation explained local topography also find increasing elevation mean wind speeds power production increase even accounting lower air density wind speeds average higher winter elevation relative increase winter compared summer higher notable exceptions explained topography carry implications wind power development view switzerland electricity shortage winter findings make strong claim wind power development especially higher elevations elsevier ltd rights reserved
recent identification highly superior autobiographical memory hsam raised possibility may individuals immune memory distortions measured hsam participants age sex matched controls susceptibility false memories using several research paradigms hsam participants controls susceptible false recognition non presented critical lure words associative word list task misinformation task hsam participants showed higher overall false memory compared controls details photographic slideshow hsam participants equally likely controls mistakenly report seen nonexistent footage plane crash finding false memories superior memory group suggests malleable reconstructive mechanisms may fundamental episodic remembering paradoxically hsam individuals may retrieve abundant accurate autobiographical memories using fallible reconstructive processes
objective study evaluate whether sexual development differs boys prepubertal obesity boys normal weight enrolled healthy obese normoweight schoolboys shenyang city liaoning china eligible boys tanner stage years age baseline measured testosterone estradiol concentrations saliva assessed auxology annually years obese normoweight boys height weight body composition sex organ volume increased age percentages body fat fat mass lean mass higher obese normoweight boys mean testicular volume smaller obese boys normoweight boys sex hormone concentrations increased age except testosterone obese boys year follow year estradiol concentrations significantly higher obese boys normoweight boys excessive adiposity prepubertal boys might affect testicular volume possibly high estradiol low testosterone concentrations
paper show correlation shear tensile test direct shear test within field geosynthetic clay liners gas proven former may serve substitute latter adhesion value gcls clay mineral sealing layers widespread used used waste contaminated soil caps closures landfill base liners gas vapor seals vertical barriers etc gcls often bentonite encased two geotextile layers connected fibers either needle punching stitch bonding results peel tests shear box tests currently used establishing internal shear failure gcls paper analyzes mechanical shear behavior needle punched gcls gcls zero stress condition one hand large direct shear test astm gcls specimens used study shear behavior specifically assessing adhesion value hand shear tensile test showed maubeuge ehrenberg maubeuge ehrenberg comparison peel bond shear tensile test methods needle punched geosynthetic clay liners geotextiles geomembranes used study shear tensile strength comparing test methods average shear tensile value kpa obtained closer average adhesion value kpa dominant failure mechanisms depending test conditions dry hydrated conditions however strongly depends type carrier geotextiles connections elsevier ltd rights reserved
present paper aims explore big data concept order answer question whether necessity hidden agenda promote disrupting new technologies ascertained unlike traditional data new data deluge would special characteristics therefore would completely new performance current technologies could enhanced using concepts bionic data abionic data way many abionic data would become bionic data use iot big data analytics big data technologies analysis big data definitions delivers three types statements new avalanche data become uncontrollable current technologies including software relational databases management unable cope new requirements new technologies required access process new types semi structured unstructured data opinion characteristics traditional data cover also big data characteristics described words beginning letter refer data big data analytics big data technologies extensions previous data analysis existing technologies therefore concept big data promotes disruption process embodied new types data analysis models technologies major changes society last decades dramatic previous global national organizational infounation systems easily categorized traditional systems becoming target disruption phenomenon due new technologies
noheda archaeological site unique exceptional size quality conservation condition roman mosaic pavement covering urban pars tent installed protection rain sun interest characterise microclimate remains six probes relative humidity temperature sensors installed purpose microclimate monitoring allowed check relative humidity differences resulting groundwater level well inner sensors reaching maximum temperatures higher outdoors ones consequence non ventilated tent covering archaeological site microclimatic conditions archaeological site deemed detrimental conservation mosaics thus summer expanded clay geotextile installed mosaics corrective action outcomes study proven effectiveness solution control temperature relative humidity helping configure stable microclimate suitable preservation mosaic
road freight transport considered one dangerous industries australia accounting work fatalities whilst system reform change policy practice needed clear reform approaches used drive article argues road freight transportation reform underpinned systems thinking approach efforts understand crash causation focused beyond driver identify contributing factors levels road freight system accordingly present findings study examined whether australian coronial investigations road freight crashes reflect support appropriate system reform content analysis used identify contributing factors interrelations implicated road freight crashes described publicly available australian coroner inquest reports last years results found evidence suggest coronial inquests provide understanding complex system factors influencing road freight transportation crashes australia however lack evidence suggest understanding system based reform based identification reductionist focused recommendations concluded researchers practitioners government industry need work together develop prevention efforts focused system reforms systems thinking based data collection analysis frameworks urgently required help develop understanding road freight transportation elsevier ltd rights reserved
hip fracture dementia increasing incidence global ageing population need development specific procedures targeting optimal treatment outcomes patients paper looks primarily factors limit access subacute rehabilitation services growing body evidence suggests access timely inpatient rehabilitation increases functional outcomes patients dementia without information gathered searching electronic data bases scopus medline cinahl health source nursing academic addition psychinfo cochrane library relevant articles using search terms dementia alzheimer hip fracture subacute rehabilitation convalescence period abstracts scanned identify articles discussing eligibility access total nine papers identified directly addressed topic papers discussing success failure rehabilitation improved models care also reviewed barriers access discussed literature include information management management comorbidities attitudes resource availability quality evidence education identifying factors identify strategic points intervention across trajectory prevention treatment rehabilitation may improve outcomes growing group vulnerable patients emerging best practice patients also discussed
aim study determine whether differences levels depression among players injured uninjured players participants football indoor footballplayers aged years mean age register injuries based identification registration system used fifa injury protocol used assess depression depression scale dass questionnaire used used descriptive cross sectional design results indicate injured players scored higher uninjured depression variable although differences statistically significant
objective study effect presence fibromyalgia common clinical disease activity indices patients psoriatic arthritis psa methods seventy three consecutive outpatients psa mean age yrs females enrolled prospective cross sectional study determined according american college rheumatism criteria patients underwent clinical evaluation disease activity completed health assessment questionnaire haq bath ankylosing spondylitis disease activity index basdai dermatology life quality index leeds enthesitis index lei disease activity evaluated using composite psoriatic disease activity index cpdai minimal disease activity mda disease activity index psoriatic arthritis dapsa scores results overall prevalence patients women patients cpdai dapsa scores significantly higher patients coexisting psa respectively patients psa respectively none patients psa met criteria mda whereas psa patients haq basdai lei scores significantly worse patients psa associated conclusion coexisting related worse scores tested measures patients psa influence taken consideration treatment algorithm avoid unnecessary upgrading treatment
background patients ankylosing spondylitis increased risk developing inflammatory bowel disease ibd aimed determine variation fecal calprotectin years relation disease activity medication also study incidence predictors development ibd methods fecal calprotectin assessed baseline year follow patients answered questionnaires underwent clinical evaluations baseline year follow ileocolonoscopy performed patients fecal calprotectin respectively medical records checked diagnoses ibd follow period results fecal calprotectin found two thirds patients study visits patients fecal calprotectin changed two measuring points baseline fecal calprotectin positively correlated ankylosing spondylitis disease activity score based reactive protein bath ankylosing spondylitis disease activity index bath ankylosing spondylitis functional index reactive protein erythrocyte sedimentation rate fecal calprotectin year follow use nonsteroidal anti inflammatory drugs nsaids associated higher fecal calprotectin week cessation nsaids resulted drop median fecal calprotectin use tumor necrosis factor tnf blockers associated lower fecal calprotectin visits users tnf receptor fusion proteins significantly higher fecal calprotectin users anti tnf antibodies year follow year incidence crohn disease predicted high fecal calprotectin conclusions fecal calprotectin elevated majority patients associated disease activity medication visits developed patients high fecal calprotectin main predictor thereof results support link inflammation gut musculoskeletal system propose fecal calprotectin may potential biomarker identify patients risk developing ibd
isogeometric analysis iga fundamentally seeks bridge gap engineering design high fidelity computational analysis using spline functions finite element bases however additional computational design paradigms must taken consideration ensure designers take full advantage iga especially within context design optimization work propose novel approach employs iga methodologies still rigorously abiding paradigms advanced design parameterization analysis model validity interactivity entire design lifecycle utilizes consistent geometry description contained within single platform unified workflow iterative design optimization naturally integrated proposed methodology demonstrated iga based parametric design optimization framework implemented using grasshopper algorithmic modeling interface rhinoceros framework capable performing iga based design optimization realistic engineering structures practically constructed use complex geometric operations demonstrate framework effectiveness internally pressurized tube wind turbine blade highlighting applicability across spectrum design complexity addition inherently featuring advantageous characteristics iga seamless nature workflow instantiated framework diminishes obstacles traditionally encountered performing finite element analysis based design optimization elsevier rights reserved
gamification aims implement game features non game contexts goal increasing motivation individuals performing specific task set tasks tasks focus cognitive behavior change overcoming anxiety physical behavior change overcoming shoulder injury current gamification methods primarily serve guidelines principles design gamified applications moreover methods often overlook complexity actually implementing game features consider effects game features individuals ability perform target task knowledge gap exists understanding tradeoffs complexity implementing game feature impact increasing individuals motivation performance particular task set tasks paper presents method evaluating complexity implementing game features physical effort required perform tasks application specific focus physically interactive gamified applications designers gain fundamental understanding implementation specific game features contributes toward objective application case study presented focuses physically interactive gamified applications virtual environment empirical results measuring effects game features participants performance presented provide evidence support metrics proposed study knowledge gained work inform designers manage resources efficiently predict possible design issues meeting objective application creating gamification applications elsevier ltd rights reserved
flexible geotextile structures widely used coastal engineering geotextile mattress used bottom protection engineering sand filled geotextile tube used reclamation project kind structure adapt varying bathymetry condition quite well significant engineering effect sediment structure eroded cavity occurs geotextile material may ripped continuous wave action especially shallow water zone however failure mechanism still clear dynamic response geotextile structure regular waves firstly studied order study tensile stress geotextile structures caused wave series physical models designed selected geotextile structure condition numbers tensile force sensor addicted around edge geotextile material fixed bottom wave flume changing wave parameter water depth relationship tensile stress wave parameters obtained discussed turns tensile force detected experiment much less upper limit material tensile strength means geotextile may easily damaged tensile stress caused waves suggested structure may break due abrasion structure internal material details discussion experimental data presented published elsevier ltd
paper polarization sensitive metamaterial absorber proposed metamaterial absorber structure consist plus shaped structure surrounded square loop proposed proposed metamaterial absorber unit cell provides approximately unity absorption ghz design ultrathin polarization sensitive absorber based band applications absorber design simulated different incident polarization angles tune single band dual band response different frequency slots band obtain best response substrate material substrate height used metamaterial absorber used stealth technology battlefield solar cell airborne radar
note propose symbolic models networks discrete time nonlinear control systems subsystem composing network admits incremental input state stable lyapunov function small gain theorem type conditions satisfied network symbolicmodels one associated subsystem composing network proposed shown approximately bisimilar original network desired accuracy
existing methods extracting titles html web page mostly rely visual structural features however approach fails case service based web pages advertisements often given visual emphasize main headlines improve current state art propose novel method combines statistical features linguistic knowledge text segmentation using annotated english corpus learn morphosyntactic characteristics known titles define part speech tag patterns help extract candidate phrases web page evaluate proposed method compared two datasets titler mopsi evaluated extracted features using four classifiers naive bayes svm clustering experimental results show proposed method outperform solution used google titler corpus mopsi dataset offers readily available solution title extraction problem elsevier ltd rights reserved
researchers hypothesised meteorological factors may impact acute cerebrovascular diseases aim study determine impact meteorological factors occurrence acute cerebrovascular events middle aged kaunas population kaunas stroke register data used data meteorological factors time period obtained lithuanian hydrometeorological service kaunas meteorological station analysed cases stroke ischemic strokes composed haemorrhagic strokes according poisson regression analysis significant negative correlation ischemic haemorrhagic types stroke ambient air temperature found beta coefficient respectively results arima showed ambient temperature day stroke onset associated occurrence ischemic haemorrhagic types stroke temperature lower risk stroke higher respectively low temperature event day days event associated higher incidence haemorrhagic stroke women low ambient temperature event day increased incidence haemorrhagic stroke subjects years high wind speed event day associated higher incidence ischemic stroke older subjects meteorological factors may impact risk acute cerebrovascular events health care providers focus preventive measures reduce risks
lactobacillus plantarum lactic acid bacterium commonly found fruits vegetables also used variety food fermentations strains species also regularly reported anti fungal probiotic activity genotyping methods used differentiate strains species thus determining strains related however plantarum currently used methods limitations including dna band profile interpretation difficulty cost study new genotyping method based multi locus variable number tandem repeat analysis mlva developed compared previously reported randomly amplified polymorphic dna pcr rapd pcr method plantarum selection antifungal strains plantarum isolated heterogeneous sources cheese silage sauerkraut vegetables probiotic product rapd pcr revealed different profiles resulting hunter gaston discrimination index value new mlva method compares lengths repetitive regions within lpxtg motif containing surface protein genes differentiated plantarum strains different subtypes leading value interestingly additional plantarum isolates obtained previous study screen antifungal activity common cheese spoilage mould penicillium commune possessed rapd pcr mlva profile commercial probiotic strain plantarum study demonstrates new mlva method used simply inexpensively differentiate plantarum strains provide information regarding strain relatedness thus potential insight strain properties elsevier ltd rights reserved
soil borne gram positive bacteria aneurinibacillus migulanus strain nagano shows considerable potential biocontrol agent plant diseases contrast migulanus nctc proved less effective inhibition plant pathogens nagano strain exerts biocontrol activity gram positive gram negative bacteria fungi oomycetes production gramicidin apart antibiotic effects increases rate evaporation plant surface reducing periods surface wetness thereby indirectly inhibiting spore germination elucidate molecular basis differential biocontrol abilities nagano nctc compared production biosurfactant secretion addition genome mining genomes results proved using oil spreading blood agar lysis surface tension tomato leaves wetness assays nagano showed increased biosurfactant secretion comparison nctc genome mining indicated presence genes nagano nctc two amino acid units difference strains using models duet server predicted decrease stability nctc synthase iii nagano produced two additional like molecules molecular weight molecular weight one two ornithine residues replace lysine peptide also negative correlation surface tension quantity present nagano nagano genome full protein network exopolysaccharide biosynthesis contrast nctc lacked first enzyme network nctc unable form biofilms observed nagano different molecular layers mainly gramicidin secondary metabolite production account differential biocontrol abilities nagano nctc work highlighted basis differential biological control abilities strains belonging species demonstrates techniques useful screening effective biocontrol strains environmentally friendly secondary metabolites used manage plant pathogens field
introduction janus kinases jaks family four enzymes jak jak jak tyrosine kinase tyk critical cytokine signalling strongly linked cancer inflammatory diseases currently two launched jak inhibitors treatment human conditions tofacitinib rheumatoid arthritis ruxolitinib myeloproliferative neoplasms including intermediate high risk myelofibrosis polycythemia vera areas covered review covers patents claiming activity one jak family members period inclusive covers patents applicants split two parts authors ordered recent patents according primary applicant name part covering expert opinion inhibition jak family kinases area growing interest catalysed maturity data marketed inhibitors ruxolitinib tofacitinib late stage clinical trials many applicants pursuing traditional fast follower strategies around inhibitors range chemical strategies adopted challenge show sufficient differentiation originator compounds since dose limiting toxicities agents appear target mechanism related also considering agents may available generic compounds time follower agents reach market
game designers deal complex task monitoring emotional state players games different elements game effect player emotional status since game play experience occurs almost unconsciously traditional methods think aloud may disrupt playing experience thus skewing results obtained methods include fitting cables electrodes player monitor biological information although devices offer significant accurate results commonly found may cause discomfort playing games propose webcam based heart rate monitoring method used predict player emotional state first analyzed change heart rate respect players emotional state allowed find correlation emotional states frustration fun challenge boredom second objective create webcam based method monitor heart rate performed extracting rgb channels face region retrieving underlying components using dimensionality reduction method results obtained webcam based method far perfect expected since performing tests realistic conditions last objective predict player emotional state using heart rate obtained webcam based method accuracy prediction exceeded initial aim system implemented unity make integration adoption easier
detection glucose plays significant role diagnostics management diabetes thus desired develop non noble metal electrocatalyst nonenzymatic glucose sensing work demonstrates first use monolithically integrated copper phosphide nanowire copper foam cup efficient catalyst electrochemical oxidation glucose nonenzymatic glucose sensor cup exhibits low detection limit signal noise ratio linear range also shows high anti interference property normally existing electroactive species including lactose fructose ascorbic acid uric acid urea dopiamine sucorse well excellent resistance chloride poisoning application glucose detection human serum sample also demonstrated successfully elsevier rights reserved
functional data analysis become major branch nonparametric statistics fast evolving field peter hall made fundamental contributions area theoretical underpinnings wrote papers functional data analysis tenured faculty member appointment department statistics university california davis article describes aspects appointment academic life davis also major results functional data analysis along brief history area concludes outlook new types functional data emerging field random objects subsumes functional data analysis deals complex data structures
electrochemical impedance spectroscopy eis widely used characterize charge carrier transfer charge storage process charge carrier transfer process may affected media viscosity eis used monitor curing processes epoxy amine blends first attempt new equation proposed character curing process estimate curing degree resins resins curing agents curing processes significant effect product properties monitoring curing processes certain resin curing agent system helpful design appropriate formulation epoxy amine blends model system prepared diglycidyl ether bisphenol epoxy resin different ratio phenalkamine modified cardanol curing agent curing processes epoxy amine also investigated differential scanning calorimetry dsc employed comparative method verify eis results good agreement obtained two methods especially higher curing temperature condition demonstrates great promise monitor curing processes using eis eis results also modeled equivalent electrical circuits eec simple win software analysis results might provide insights optimizing epoxy amine ratio performance cured epoxy resin monitoring process related viscosity change elsevier rights reserved
use nuclear energy generate electric power crucial meet high energy demand modern economy newly constructed nuclear power plants npps trend among control systems replace obsolete analog hard wired systems contemporary digital cyber based systems therefore cyberphysical security well dependability critical issues safety critical npps paper present different levels layers protection manage cyber physical security also discuss interrelationship cyber physical attacks adopt generalized stochastic petri nets quantitatively evaluate intrusion probability propose new cyberframework show proposed framework prevents cyberattacks also conforms cybersecurity regulations also propose physical framework prevent potential physical attacks finally discuss dependability three metrics reliability maintainability availability case study presented demonstrate proposed cyberframework highly dependable analyzing steady state probabilities
histone deacetylase inhibitors hdaci epigenetic modifiers single agent activity patients cutaneous peripheral cell lymphoma ctcl ptcl mechanisms preferential activity remain unclear although would term class effect differences efficacy safety likely result varying chemical structures classes histone non histone targets potencies clinical dosing three hdaci single agent approval relapsed refractory tcl united states romidepsin ctcl ptcl vorinostat ctcl belinostat ptcl although comparison agents difficult due differences patient populations review aimed provide detailed overview clinical data hdaci tcl use clinical practice despite early concerns data demonstrate cardiac safety hdaci highlighting need maintain electrolytes normal range monitor interval initially administering antiemetics drugs prolong improve response rates durability responses hdaci clinical investigation combination chemotherapy regimens various novel agents
ball beam basic reference point system high nonlinearity unstable system dynamics many simple present day control methods used balance ball beam system goal project model control ball beam system considering beam angle servo motor designing controllers control ball position lagrange approach used find ball position system based energy balance system based transfer function state space model open loop system closed loop system designed system designed using two degrees freedom nonlinear characteristic second order system regulated using pid controller controller controls ball position moving beam using motor beaten disturbances parameters pid tuned using pid tuning algorithm order analyse accomplishment pid learn effect simplifying expectation two control methods designed implemented using proportional derivative integral pid non model based control method proportional derivative proportional integral combination model based non model based control methods
introduction purpose study explore presence neuropsychiatric disorders patients neurocysticercosis ncc method patients untreated ncc healthy controls underwent psychiatric neuropsychological assessments results majority patients ncc group least psychiatric diagnosis compared minority control group frequency neurocognitive disorders particularly dementia major neurocognitive disorder significantly higher group patients ncc discussion study confirms relationship ncc cognitive disorders
functional dependencies fds represent potentially novel interesting patterns existent relational databases discovery functional dependencies wide range applications database design knowledge discovery data quality assessment etc growing interest problem functional dependencies discovery last ten years however existing functional dependencies discovery algorithms mainly applied centralized small data far challenging discover functional dependencies big data paper propose efficient functional dependencies discovery algorithm mining functional dependencies distributed big data prune candidate fds node local fragmented data batch verify candidate fds parallel load balance taken account discovering functional dependencies experiments show proposed algorithm effective real dataset synthetic dataset
system monitoring help detect anomalies crafting monitors robot systems difficult due inherent complexity changing uncertain operating environment address challenge automatically inferring system invariants synthesizing invariants monitors detect faults approach inspired state art software engineering methods approach novel automatically derives invariants messages invariants types tailored match spatial temporal architectural attributes robotic systems automatically classifies synthesizes invariants online invariants monitor node assessed approach context two unmanned aerial vehicle systems running robot operating system found monitoring inferred invariants reduce system failure rates facing unexpected contexts detect differences lab environment field deployments
eckol dieckol important phlorotannins found edible brown algae including eisenia bicyclis ecklonia stolonifera others inhibition monoamine oxidase mao play important role early management parkinson disease aim study determine effectiveness eckol dieckol isolated methanolic extract bicyclis inhibition human mao mao hmao hmao sensitive enzyme based chemiluminescent assay kinetics methods used investigate enzyme inhibition mode inhibition molecular docking simulation performed clarify binding characteristics eckol dieckol hmao hmao results suggested methanolic extract bicyclis isolated phlorotannins eckol dieckol potent inhibitory activity hmao hmao enzyme based kinetics results demonstrated eckol mixed non competitive inhibition hmao hmao respectively dieckol non competitively inhibited hmaos molecular docking simulation predicted eckol dieckol exhibit higher binding affinity towards hmao hmao hydrogen bonding hydrophobic interactions findings implicate eckol dieckol inhibitors hmaos might potential value management
family oriented services common one would expect given widespread endorsement family centred care role parents supporting optimal child outcomes legislation literature indicating parent outcomes important right published service delivery frameworks describing scope services could delivered promote parent family wellness scoping review conducted identify types family oriented services parents children physical disabilities intellectual impairments information synthesized conceptual framework services inform service selection design scoping review recent literature performed capture descriptions services targeting parents families children physical disabilities intellectual impairments published six year period six databases searched retrieved articles screened using inclusion exclusion criteria thirty six relevant articles identified based descriptions services articles along seminal articles describing nature desirable services propose needs based capacity enhancing framework outlining continuum family oriented services parents children disabilities framework includes six types services meet parent family needs organized continuum fundamental information education services supporting parents deliver services meet child needs variety services addressing parents needs support groups psychosocial services service coordination framework provides pediatric rehabilitation service organizations way consider different possible family oriented services implications include particular importance providing information resources support groups psychosocial services meet parents needs enhance capacity promote family wellness also opportunity provide composite parent child services address needs parents children
reverse correlation techniques provide data driven approach model internal representations unconstrained way used approach model social perception faces task participants repeatedly selected two face images created superimposing randomly generated noise masks face face looked trustworthy conditions untrustworthy dominant submissive calculated classification images cis averaging selected images trait judgments independent participants well objective metrics showed cis visualized intended traits well furthermore tests pixel clusters showed diagnostic information resided mostly mouth eye eyebrow hair regions current work shows provides excellent tool extract psychologically meaningful images map onto social perception
background limited studies assessing economic burden hiv aids terms direct costs published study related productivity costs nepal therefore study explores detail economic burden hiv aids including direct costs productivity costs paper focuses direct costs seeking treatment productivity costs related factors affecting direct costs productivity costs methods study cross sectional quantitative study primary data collected structured face face survey people living hiv aids plhiv study conducted six representative treatment centres six districts nepal data analysis regarding economic burden direct costs productivity costs performed household perspective descriptive statistics used regression analyses applied examine extent nature determinants burden disease correlations results average total costs due hiv aids sum average total direct average productivity costs adjustment coping strategies nepalese rupees nrs per month month sample households average monthly income average total direct costs seeking hiv aids treatment nrs average productivity costs adjustment coping strategies nrs average monthly productivity losses adjustment coping strategies days per person major determinants direct costs household income occupation health status respondents respondents accompanied study district health status respondents ethnicity sexual orientation study district important determinants productivity costs conclusions study concluded hiv aids caused significant economic burden plhiv families nepal study number policy implications different stakeholders provision social support income generating programmes hiv affected individuals families decentralising treatment services district seem viable solutions reduce economic burden hiv affected individuals households
instead analog electronic circuits components digital controllers capable active multi resonant piezoelectric shunting applied elastic metamaterials integrated piezoelectric patches thanks recently introduced digital control techniques shunting strategies possible transfer functions hardly realized analog circuits example pole zero method developed design single multi resonant bandgaps adjusting poles zeros transfer function piezoelectric shunting directly large simultaneous attenuations three frequency bands deep subwavelength scale normalized frequency low achieved underlying physical mechanism attributable negative group velocity flexural wave within bandgaps digital controllers readily adapted via wireless broadcasting bandgaps tuned easily unlike electric components analog shunting circuits must tuned one one manually theoretical results verified experimentally measured vibration transmission properties large insulations low frequency ranges observed
input output based economic policies designed reduce water pollution fertilizer runoff adjusting management practices theoretically justified well understood yet practice adjustment fertilizer application land allocation may sluggish provide practical guidance policymakers regarding relative magnitude speed adjustment input output based policies dynamic dual model corn production takes fertilizer one several production inputs measure short long term effects policies affect relative prices inputs outputs short long term price elasticities fertilizer application also total time required different policies affect fertilizer application adjustment rates capital land estimates allow compare input output based policies based relative cost effectiveness using data indiana illinois find input based policies cost effective output based counterparts achieving target reduction fertilizer application show input output based policies yield adjustment fertilizer application speed adjustment takes place short term elsevier ltd rights reserved
polymer constitutive equations implemented within strength materials based micromechanics method predict nonlinear strain rate dependent deformation polymer matrix composites based constitutive polymer model developed goldberg nonlinear strain rate dependent triaxial braided composite analyzed verify formulation tensile deformations representative polymer computed across wide range strain rates results computed using developed constitutive equations correlate well experimental data
method voltage stabilization based upon static var generator svg proposed paper solve prominent problems high energy loss low terminal voltage country electrical network chaoyang lingcheng electric line relying control strategy selection closed loop control amount regulator well closed loop current control svg possible make output status svg change actual situation system thus stabilize voltage power system
child sexual abuse csa affects children annually united states primary obstacle success public health prevention strategy lack knowledge around community level risk factors csa evaluated community level characteristics children seeking care suspected csa greater houston area total incidence rate medical evaluations suspected csa children abstracted medical charts children sought medical evaluation suspected csa three main medical systems greater houston area evaluated community level variables american community survey zip codes children lived mean number cases per greater houston zip code range zip codes case three sites surveyed zip codes higher houston average rate vacant houses never married females unemployed labor force high family poverty rate associated increased rate children seeking care suspected csa demonstrated zip codes level characteristics associated increased rate children seeking care suspected csa modelling process data implications community based strategies aimed improved surveillance prevention csa process identifying locally specific community level factors suggests target areas particular socioeconomic characteristics associated increased rate seeking csa evaluations
memory corruption vulnerability prevalent software written using languages lack memory safety features become serious problem number attacks exploit vulnerability increased specifically vulnerability allows control flow hijacking memory corruption attack involves well known dangerous program stack several countermeasures proposed academia information technology industry thwart attacks countermeasures implemented used practice however memory corruption attacks continue serious problem even countermeasures simply bypassed new attacks paper survey classify protection mitigation technologies especially pervasive operating systems compilers study aims organize pervasive countermeasures attacks present existing countermeasures address current serious problem propose modifications countermeasures implemented future
exosomes nano sized membrane bound vesicles released cells transport cargo including dna rna proteins cells form intercellular communication addition role intercellular communication exosomes beginning appreciated agents immunoregulation modulate antigen presentation immune activation suppression surveillance article summarizes multifaceted functions exosomes may promote development progression chronic inflammatory lung diseases including asthma chronic obstructive pulmonary disease pulmonary fibrosis potential exosomes novel therapeutic also discussed
programmable network like sdn allows administrators program network infrastructure according service demand custom defined policies network policies interpreted centralized controller define actions rules process network traffic devices belong single domain however actual networks multi domain several domains interconnected sdn controllers domain define monitor policies domains network administrators ensure policies origin policies enforced domains directly managed foreign domains present audit multi domain sdn policy verifier identifies whether origin policy enforced foreign domains audit comprises model network topology policies flows audit protocol gather information actions performed network devices carry flows interest validation engine takes information detects security policy violations extension openflow protocol enable external auditing paper presents approach illustrates application using example considering multiple sdn networks
convergent evidence suggests schizophrenia disorder neurodevelopment alterations early late developmental processes hypothesized contribute disease process abnormalities certain clinical features schizophrenia working memory impairments depend distributed neural circuitry including dorsolateral prefrontal cortex dlpfc appear arise protracted maturation circuitry across childhood adolescence particular neural circuitry substrate working memory primates involves coordinated activity excitatory pyramidal neurons specific population inhibitory gamma aminobutyric acid neurons parvalbumin containing basket cells layer dlpfc understanding relationships normal development schizophrenia associated alterations dlpfc circuitry subserves working memory could provide new insights nature schizophrenia neurodevelopmental disorder consequently review following article recent findings regarding alterations dlpfc layer circuitry schizophrenia developmental refinements circuitry occur period working memory alterations schizophrenia appear arise progress various adverse environmental exposures could contribute developmental disturbances circuitry individuals schizophrenia
development android app study four link mechanism number revolute joints presented created app requires complete study planar kinematics position velocity acceleration setting one grounded joints input besides calculating position velocity acceleration moving elements application also classifies mechanism according grashof law feedback received students already taken courses related application topic used order quantify app performance results app calculations validated comparison results widely known textbook problems similar computer running tools well
soil moisture salinity measurement essential factors crop irrigation well increase yield grapes eminence depends water volume contents soil soil nutrients based conditions determined water demand best quality grapes wireless sensor network wsn using lot chemical fertilizers increases soil salinity reduces soil fertility soil salinity defines electrical conductivity salty soil precise agriculture systems integrated multiple sensors monitor control incident integrated wsn designed developed measure soil moisture salinity atmega microcontroller xbee soil sensors integrated across system system competent helpful automatic irrigation system soil salinity monitoring
individuals occurring illnesses risk poor outcomes related criminal justice hospitalization housing employment high fidelity evidence based models including integrated dual disorder treatment iddt associated significant outcome improvements descriptive analysis secondary datasets including full sample iddt fidelity reviews completed one state completed total iddt fidelity significantly improved baseline fidelity review second review second review third review adequate inner rater reliability second review individual items lower across reviews included practice penetration family interventions higher individual items included multi disciplinary team integrated treatment specialist time unlimited services treatment measures higher organizational measures baseline subsequent reviews large state wide sample iddt took time implement improved fidelity occurred baseline third review variance components practice significant
thrombopoietin tpo potent cytokine stimulating thrombopoiesis therapy exogenous tpo limited formation antibodies cross reacting endogenous tpo mimetics tpo compounds antigenic similarity tpo eltrombopag orally active nonpeptide small molecule binds transmembrane portion tpo receptor mpl initial trials eltrombopag centered immune thrombocytopenia itp due increased destruction decreased production platelets eltrombopag day shown highly effective raising platelet count itp suboptimal response immunosuppression splenectomy successful results led exploration eltrombopag thrombocytopenic disorders hepatitis viral infection eltrombopag raises platelet count sufficiently enough allow treatment ribavirin pegylated interferon mpl expressed hematopoietic cells eltrombopag use myelodysplastic syndrome mds acute myeloid leukemia aml might enhance leukemic proliferation clinical trials eltrombopag mds aml however shown amelioration thrombocytopenia without promoting disease progression severe aplastic anemia saa responding immunosuppression anti thymocyte globulin atg cyclosporine eltrombopag single agent day results overall response rate high doses adverse effects including pigmentation gastrointestinal upset hepatic derangement become evident current studies examined first line use eltrombopag combination atg saa recent study eltrombopag used day horse atg resulted overall response rate newly diagnosed saa patients complete response rate clonal karyotypic aberrations however found saa patients treated eltrombopag safety efficacy eltrombopag saa require evaluation particularly used less intensive immunosuppression
evaluated correlation educational attainment structural volume shape morphometry bilateral hippocampi amygdalae sample non demented older adults elevated sociodemographic risk cognitive functional declines men women significant education volume correlation detected either structure however performing shape analysis observed regionally specific associations education adjusting age intracranial volume race sub dividing hippocampus amygdala compatible subregions found education positively associated size variations subiculum subregions hippocampus basolateral subregion amygdala addition detected greater left versus right asymmetric pattern shape education correlation hippocampus amygdala asymmetric association largely observed men versus women findings suggest education youth may exert direct indirect influences brain reserve regions vulnerable neuropathologies aging dementia specifically alzheimer disease
background health physical education hpe teachers known social personal employment related pressure appear physically fit use dangerous dieting weight control practices problematic due influence may health potential model attitudes behaviours future students methods paper compare body image dieting disordered eating exercise behaviours first year hpe non hpe teacher education students participants first year university student pre service teachers hpe non hpe three universities australia completed self report questionnaires analysis covariance logistic regression analyses used determine differences attitudes behaviours two groups males females separately results found male hpe participants significantly higher levels drive muscularity obligatory exercise likely classified exercise disorder dieting using steroids non hpe students female hpe students likely engage self reported excessive exercise higher scores obligatory exercise questionnaire classified exercise disorder conclusion findings important confirm presence dieting disordered eating attitudes behaviours among teacher education students highlight male hpe teachers potentially vulnerable group results may inform implementation intervention programs teacher education students ensure personal wellbeing professional capacity promoting positive body image nutrition physical activity among young people
fretting fatigue phenomenon occurs two parts contacted one parts subjected cyclic load fretting decreases fatigue life materials drastically half even therefore investigation fretting fatigue life materials important subject fretting fatigue tests usually performed using universal hydraulic testing devices work rotating bending apparatus fretting fatigue test introduced cyclic load provided adjustable eccentric load apparatus called rbff machine abbreviation rotating bending fretting fatigue eccentric load measured load cell coefficient friction fretting load measured foil strain gauges using wheatstone bridge configuration performance machine verified comparison fatigue lives number alloy samples shimadzu rotating bending fatigue testing machine rbff results shows close assent operations two testing rigs main privileges rbff simplicity respect universal devices cheapness coefficient friction pads specimen evaluation test rbff also capability used soft hard metals advanced high low temperature
developing brains young children highly sensitive input social environment nurturing social experience time promotes acquisition social cognitive skills emotional competencies however many young children confronted obstacles healthy development including poverty inappropriate care violence enhanced sensitivity social environment means highly susceptible adverse childhood experiences one source social adversity early life stem parenting harsh inconsistent non sensitive hostile parenting considered cornerstone early socio emotional development adverse parenting style associated adjustment problems higher risk developing mood behavioral disorders importantly growing literature showing important predictor parenting behavior parents especially mothers parented review examine adversity early life affects mothering behavior later life effects may perpetuated inter generationally relying studies humans animal models consider evidence intergenerational transmission mothering styles describe psychological underpinnings mothering including responsiveness young executive function affect well physiological mediators mothering behavior including hormones brain regions neurotransmitters consider development relevant domains may affected adversity experienced early life finally explore genes early experience interact predict mothering behavior including involvement epigenetic mechanisms understanding adverse parenting begets adverse parenting next generation critical designing interventions aimed preventing intergenerational cycle early adversity ibro published elsevier ltd rights reserved
five key materials engineering components component impacted working performance polymer actuator material investigated research investigated change actuation performance occurred change made material investigated polymer crosslink density polymer chain length polymer gelation type density reactive units well addition binders polymer matrix five play significant role need addressed molecular level optimize polymer gel use practical actuator material biomedical industrial use
vitamin metabolite retinoic acid acts master regulator cellular programs mast cells mcs primary effector cells type allergic reactions recently uncovered human cutaneous mcs enriched network components skin cells yet direct experimental evidence significance axis limited skin derived cultured mcs exposed seven days investigated flow cytometry brdu incorporation annexin epsilon microscopy qpcr histamine quantitation protease activity degranulation assays found size granularity remained unchanged potently interfered proliferation conversely modest survival promoting effect noted granule constituents histamine tryptase remained unaffected striking impact chymase whose expression dropped gene peptidase activity newly uncovered mrgprx performed similarly chymase intriguingly fostered allergic degranulation way completely uncoupled epsilon expression simultaneously restricted mrgprx triggered histamine release agreement reduced receptor expression vitamin derived hormones thus shape skin derived mcs numerically phenotypically functionally general theme emerges implying skew mcs towards processes associated allergic inflammation driving away skin imprinted mctc mcs containing tryptase chymase signature chymase mrgprx collectively mcs substantial targets skin retinoid network
monocytes critical components innate immune system differentiate dendritic cells dcs cutaneous neoplasms dendritic cell origin uncommon mostly represented histiocytic lesions derived primarily langerhans cells myeloid mdc recognized immunology literature well defined neoplastic cutaneous counterpart eleven patients diagnosis cutaneous mdc dyscrasia evaluated routine hematoxylin eosin stain performed followed selective phenotypic studies patients older without gender predilection exhibited asymptomatic papular skin rash waxing waning course biopsies demonstrated dermal based monomorphic small mononuclear cell infiltrate cells expressed cdc hla well granzyme lysozyme defines terminally differentiated monocyte dendritic cells expression bdca tumor cells indicated myeloid dendritic cells mdc patient prior subsequent diagnosis abnormal bone marrow biopsy included myelodysplastic syndrome myelofibrosis chronic myelomonocytic leukemia acute myelogenous leukemia propose term cutaneous mdc cell dyscrasia distinctive infiltrates differentiated mdcs reflective underlying myeloproliferative disease clinical course variable indolent although strongly correlated myelodysplastic syndrome included leukemia elsevier inc rights reserved
end auxilec built successfully tested kva homopolar generator integrated turbo engine manufactured microturbo generator ran rpm provided regulated vdc rectified output generator turbo engine assembly supplied resistive load hours endurance test test program also included successful starting engine homopolar generator
background aims chronic hepatitis global health problem estimated million hepatitis virus hcv infected individuals risk progressive liver disease hepatocellular carcinoma hcc autotaxin atx gene name enpp phospholipase diverse roles physiological pathological processes including inflammation oncogenesis clinical studies reported increased atx expression chronic hepatitis however pathways regulating atx role viral life cycle well understood methods vitro hepatocyte vivo liver culture systems along chimeric humanized liver mice hcc tissue enabled assess interplay atx hcv life cycle results hcv infection increased hepatocellular atx rna protein expression hcv infection stabilizes hypoxia inducible factors hifs investigated role transcription factors regulate atx vitro studies show low oxygen increases hepatocellular atx expression transcriptome analysis showed positive correlation atx mrna levels hypoxia gene score hcc tumour tissue associated hcv aetiologies importantly inhibiting atx lysophosphatidic acid lpa signalling reduced hcv replication demonstrating positive role phospholipase viral life cycle lpa activates phosphoinositide kinase stabilizes hif alpha inhibiting hif signalling pathway abrogates pro viral activity lpa conclusions data support model hcv infection increases atx expression supports viral replication hcc progression lay summary chronic hepatitis global health problem infected individuals risk developing liver disease progress hepatocellular carcinoma autotaxin generates biologically active lipid lysophosphatidic acid reported play tumorigenic role wide number cancers study show hepatitis virus infection increases autotaxin expression via hypoxia inducible transcription factor provides environment liver promotes fibrosis liver injury importantly show new role lysophosphatidic acid positively regulating hepatitis virus replication published elsevier behalf european association study liver
purpose review ankle sprains account sports injuries usa lead chronic ankle instability chronic ankle instability classified functional mechanical combination diagnosed using combination physical exam mri stress radiographs review focuses different approaches treatment including non operative operative techniques chronic ankle instability including reviewing traditional procedures well novel newer techniques recent findings based existing literature non operative treatment always precede operative treatment chronic ankle instability rehabilitation fails brostrom gould type ankle stabilization preferred surgical option recent literature suggests arthroscopic repair might reduce recovery time improve outcomes certain populations however higher rates complication following surgeries high risk populations literature reports ligament repair peroneus brevis transfer could effective treatment option summary currently varying surgical techniques exist treatment chronic ankle instability recently reported techniques show promise important note little evidence showing successful traditional techniques imperative future studies focus outcomes complication rates newer procedures
background atopic dermatitis day increasing prevalence globally prevalence reported different country even prevalence known countries especially developing countries scarcity regard prevalence associated risk factors among children ethiopia settings aim study determine magnitude associated factors atopic dermatitis among children ayder referral hospital mekelle ethiopia methods facility based cross sectional study design conducted among children aged months years ayder referral hospital july september systematic random sampling technique used identify study subjects descriptive analysis done characterize study population bivariate multivariate logistic regression used identify factors associated used show strength association value used declare cut point determining level significance results among total respondents males females magnitude atopic dermatitis found multivariate logistic regression model maternal asthma aor maternal hay fever history aor atopic dermatitis history aor paternal asthma aor paternal hay fever history aor personal asthma aor hay fever history aor age months year weaning months age aor significant predictors atopic dermatitis conclusion study magnitude atopic dermatitis high relation studies conducted far country maternal paternal personal asthma hay fever histories maternal atopic dermatitis history age child age weaning independent predicators atopic dermatitis hence finding alert needs strengthening national skin diseases prevention control services particular skin care children related atopic dermatitis others avoiding early initiation supplementary feeding specially personal families atopic problem needs attention prevention activities
background minorities historically underrepresented clinical research trials despite comparatively poor health indicators recognizing dual inequalities increased disease burden decreased research participation national institute health nih revitalization act mandated inclusion reporting women minorities nih funded research progress made subsequent decades underrepresentation minorities research trials persists documented multiple disciplines however extent adequate representation reporting minority inclusion clinical trials migraine remains unknown objectives systematic review study review literature examining representation women minorities migraine clinical research trials methods first searched pubmed pertinent articles examining inclusion women minorities migraine clinical research trials second identified controlled trials migraine published since major neurology headache general medicine journals using terms migraine randomized controlled trial reviewed results manually excluded pilot studies fewer participants next determined frequently representation minorities women reported major trials factors correlated reporting whether women minority inclusion comprised ratios general population results identified relevant clinical trials met inclusion criteria trials reported gender frequency reported ethnicity race among studies women whites represented participants mean respectively studies conducted united states funded private company likely report race studies conducted exclusively outside public sponsor studies stratified efficacy safety ethnicity gender men non whites statistically underrepresented conclusions recent headache studies comply nih mandate include women minorities research trials particularly based industry funded studies whites overrepresented compared general population population migraineurs future studies strive increase minority participation investigate race based differences migraine expression treatment response medication toxicity
motivated need develop real time computation method simultaneous real time visualization force torque feedback manipulating compliant mechanisms paper presents general formulation reduced order discrete state space model solution function path lengths three dimensional curvature based beam model cbm unlike compliant beam model boundary value problem solved using shooting method state space representation decouples order cbm two sets reduced order ordinary differential equations first solves orientation moment whereas second describes deformed beam shape thus enables parallel computation deformed shape solutions orientation moments illustrative examples state space formulation real time computation method applied analyze two flexure based mobile sensing node fmn designs new design overcomes several kinematic limitations practical implementation problems commonly encountered fmn navigation tight space permits bending twisting compliant beam space discrete linear cbm two fmn designs validated experimentally well verified comparing computed results published data simulations using multishooting method finite element analysis
background reports frequent manifestation allergic diseases children attention deficit hyperactivity disorder adhd subject mounting clinical interest however evidence supporting association adhd allergies inconsistent yet systematically reviewed objective study compile assess available studies association adhd allergic diseases children methods comprehensive search using medline embase cochrane library cinahl databases completed november inclusion criteria studies research assessed allergic diseases children years age younger diagnosis adhd distinct comparison group incorporated comparative studies encompassing randomized controlled trials observational studies considered inclusion two review authors independently assessed quality selected studies use validated assessment tools performed data extraction conducted meta analysis according cochrane collaboration guidelines results five eligible studies included systematic review studies three case control two cross sectional studies majority information five studies classified low unclear risk bias meta analysis showed association children adhd asthma compared control groups five studies low quality evidence indicate association food allergy adhd three studies low quality evidence odds experiencing allergic rhinitis atopic dermatitis allergic conjunctivitis slightly higher children adhd compared control groups though substantial statistical heterogeneity notable overall effect estimates conclusions findings review meta analysis show children adhd likely asthma allergic rhinitis atopic dermatitis allergic conjunctivitis counterparts interventions including strategies managing allergies children adhd would beneficial
accurate measurement power attributes signals used communications systems become necessary aspect optimizing power consumption data throughput simple portable battery powered devices large scale base stations routers knowledge signal characteristics environment enables system reconfigure allocate power bandwidth needed combination high speed silicon based process technologies unrelenting focus precision circuit design enabled situ analog signal processing signals performed accurately practically non invasively review numerous signal measurement techniques developed analog devices reveals unusual combination high speed precision design techniques
voltage mode high input impedance differential input differential output second order band reject filter based two differential difference current conveyors ddccs one second generation current conveyor ccii presented proposed structure features high input impedance minimum number passive elements grounded high common mode rejection ratio low sensitivity tracking error sensitivity analysis proposed circuit given performance filter structure verified simulations also experimentally measured using ucc integrated circuit elsevier gmbh rights reserved
disorganization reorganization starch components considering systems different levels complexity reviewed particular attention retrogradation approach consists gradual analysis architecture starch granules followed discussion disorganization excess water high temperature subsequent reorganization model systems cereal products primary progress bottlenecks perspectives discussed elsevier ltd rights reserved
research demonstrates belief one effectiveness parent parenting efficacy linked numerous positive outcomes new parents conversely perceived inability meet expectations associated negative mental health consequences mothers fathers present paper examine impact parenting efficacy expectations mental health statuses new parents using three waves data spanning prenatal period months postpartum period sample first time mothers fathers midwestern united states find parenting efficacy negatively associated postpartum depression ppd mothers fathers throughout transition period also find mothers fathers whose parenting efficacy experiences negative expected reported higher levels ppd month postpartum effect dissipates mothers fathers months postpartum suggesting differences experiences mothers fathers transition conclude research transition parenthood continue include fathers effort better understand mental health consequences becoming parent first time well enhance interventions designed assist couples experiencing important transition
background unhealthy toileting behaviours exist among women lower urinary tract symptoms high prevalence significant effects quality life however relationship toileting behaviours lower urinary tract symptoms unclear objectives study aimed investigate prevalence lower urinary tract symptoms among female nurses association toileting behaviours lower urinary tract symptoms design cross sectional stratified cluster sampling study participants total female clinical nurses tertiary hospitals jinan capital city shandong province china methods toileting behaviour women elimination behaviours international consultation incontinence questionnaire female lower urinary tract symptoms scales used assess participants toileting behaviours lower urinary tract symptoms respectively multiple linear regression analysis used evaluate association toileting behaviours lower urinary tract symptoms results unhealthy toileting behaviours common among female nurses delayed voiding unhealthiest toileting behaviour followed place position preference voiding nearly female nurses least one lower urinary tract symptom nearly incontinence symptoms filling symptoms voiding symptoms unhealthy toileting behaviours premature voiding delayed voiding straining void positively associated lower urinary tract symptoms however lower urinary tract symptoms significantly associated voiding place position preference among control variables married history urinary tract infection associated lower urinary tract symptoms higher income regular menstrual period negatively associated lower urinary tract symptoms compared vaginal delivery caesarean delivery protective association lower urinary tract symptoms conclusion lower urinary tract symptoms among female nurses overlooked prevalence among female clinical nurses exceeded among general population women findings highlight importance avoiding unhealthy toileting behaviours especially premature voiding delayed voiding straining void unhealthy toileting behaviours significantly associated susceptibility lower urinary tract symptoms elsevier ltd rights reserved
use animals research increasing scrutiny general public funding agencies regulatory authorities ability continue perform vivo studies laboratory animals critically determined researchers respond new reality perspectives article summarizes recent ongoing initiatives within ors allied organizations ensure musculoskeletal research performed highest ethical standards goes present overview practical application reduction refinement replacement experimental design execution discusses recent guidance regard improvements way animal data reported publications overarching goal review challenge status quo highlight absolute interdependence animal welfare rigorous science provide practical recommendations resources allow clinicians scientists optimize ways undertake preclinical studies involving animals orthopaedic research society published wiley periodicals inc
contribution novel multi machine structure called planetary motor presented combines multi rotor electric motor planetary gear function compact drives frequently built using high speed electrical motor combined gear box reducing angular speed motor gear box separate functional units constructed operated seperately novel motor structure splits rotor multi rotor arrangement mechanically coupled interacting common winding system describing motor structure control scheme presented multi rotor arrangement behaves like single motor supplied conventional inverter properties drive explained verified prototype possibilities modifying structure given
traditional imaging spectropolarimetry generally requires slit moving parts electrically tunable devices use micropolarized arrays furthermore acquired raw data physical superposition interferogram image given complicated structure poor seismic capacity low detection sensitivity heavy computations approximation spectral reconstruction meeting needs applications aviation remote sensing field detection difficult overcome drawbacks new spectropolarimetric imaging technique based static dual intensity modulated fourier transform presented system consists front telescopic system two phase retarders linear polarizer wollaston prism savart polariscope linear analyzer reimaging system charge coupled device ccd array detector incident light modulated module polarization spectrum modulation consists retarders polarizer wollaston prism splits modulated incident light two equal intensities orthogonally polarized components small divergent angle passing interference module composed savart polariscope analyzer reimaging system two full polarization interferograms superposition background images interference fringes recorded simultaneously single ccd pure target image pure interference fringes simply achieved summation difference two interferograms spectral complete polarization information acquired using fourier transform pure interference fringes principle configuration system described paper reconstruction processes target image full stokes polarization spectra theoretically analyzed mathematically simulated results show system availably separate background image interference fringes target achieving high precision spectral reconstruction effective extraction complete polarization information compared features existing instruments one salient features described model use dual intensity modulation avoid mutual interference image fringes hardware conducive extraction pure interference fringes high signal tonoise ratio snr feature inadequacies traditional spectral reconstruction large computation heavy data processing low accuracy acquired information overcome moreover entrance slit front telescopic system removed greatly increases transmittance flux incident light improves snr interferogram modified savart polariscope used interference module transverse shearsplitting principle enlarges field view increases spectral resolution straight fringes thus design advantages good stability high spectrum high sensitivity large snr high precision information reconstruction low complexity data processing well simultaneous detection image spectrum complete polarization information work provide important theoretical basis practical instruction developing new spectropolarimetric imaging technique engineering applications
paper mathematical modeling cuk converter operating continuous conduction mode ccm done using signal flow graph sfg method meyson gain formula using obtained model output voltage input voltage transfer function also output control transfer function extracted moreover effects equivalent series resistors esrs stability frequency response cuk converter investigated four different states roots location bode diagram state studied using related obtained transfer function simulation results presented verify sfg performance also effects inductors capacitor resistances stability frequency response
paper presents design experimental evaluation discrete time sliding mode controller using multirate output feedback minimize structural vibration cantilever beam using shape memory alloy wires control actuators piezoceramics sensor disturbance actuator linear dynamic models smart cantilever beam obtained using online recursive least square parameter estimation digital control system consists simulink modeling software dspace controller board used identification control effectiveness controller shown simulation experimentation exciting structure resonance
high performance control quantum dynamics key development quantum technologies quantum state engineering quantum metrology theory practice quantum control enable robust cheaper technologies future industrial applications starting fundamental matter field interactions overview various approaches modelling quantum control systems control implemented either changing field material properties models built time frequency domain interconnected form quantum feedback networks review taken useful reference engineers understand quantum physics behind physicists resolve control problems control engineering point view
objective explore main psychosocial aspects influence coping disease patients parkinson disease family carers design exploratory qualitative study constitutes second phase mixed methods project setting multicenter study carried navarre collaboration primary care navarre service health osasunbidea clinica universidad navarra navarre association parkinson patients participants total participants people family carers healthcare professionals method participants selected purposive sampling focus groups conducted suitable saturation data achieved transcriptions analysed researchers content analysis results three aspects affected patients family carers coped identified features clinical practice family environment disease acceptance taking account findings strategies could foster aspects primary healthcare suggested order improve adjustment disease patients family carers conclusions healthcare people integral approach tackle symptoms control patients also deal psychosocial aspects influence coping disease patients family carers elsevier espana
carbonaceous dots exhibit increasing applications diagnosis drug delivery due excellent photo stability biocompatibility properties however relative short excitation emission melanin carbonaceous dots mcds limit applicability fluorescence bioimaging furthermore generally poor spatial resolution fluorescence imaging limits potential vivo applications due variety beneficial properties study mcds prepared exhibiting great potential fluorescence photoacoustic dual mode bioimaging mcds exhibited long excitation peak emission peak highlighting applicability fluorescence imaging absorbance peak renders mcds suitable photoacoustic imaging vivo photoacoustic signal mcds linearly correlated concentration mcds moreover mcds shown taken triple negative breast cancer cell line time concentration dependent manner vivo fluorescence photoacoustic imaging subcutaneous tumor demonstrated mcds could passively target triple negative breast cancer tissue enhanced permeability retention effects may therefore used tumor dual mode imaging furthermore fluorescence distribution tissue slices suggested mcds may distribute tumor high efficacy conclusion mcds studied offer potential application fluorescence photoacoustic dual mode imaging elsevier inc rights reserved
current day networks operate multiple hardware devices assisted numerous numbers operating systems systems may vulnerabilities explored exploited among overall malicious activity countries india ranked third china paper made attempt explore possibility quantifying various probabilities cyber system modeled different ways various attack vectors make cyber network vulnerable compromised employee insider network contributes significantly network vulnerability keeping mind various random variables affect safety cyber random space may need quantify probability associated different cyber exploitation related activities
consider strategic interactions fiscal monetary policies monetary union fiscal authority enjoys strategic advantage particular depart standard literature strategic interactions monetary unions solve three stage game two national fiscal authorities play simultaneously find always incentive leader fiscal authority play three stage game leaves fiscal authority worse demand shocks choice leads less volatile union wide fiscal stance demand supply shocks compared standard narrow coordination case volatility positively related demand shocks asymmetries elsevier rights reserved
paper utilize software engineering technique called statistical debugging experimentally identify emergent behaviors system systems apply technique agent based model ballistic missile defense system bmds component bmds operational managerial independence well geographic distribution develop simple game bmds blue attacked enemy threats red repeat game large number replications results show strategy guarantees blue win addition losing strategies winning ones finally four strategies appear half wins losses refer emergent since controlled either red blue side
paper presents investment feasibility analysis rainwater harvesting systems residential sector santa catarina state southern brazil five towns selected analysis daily rainfall data average water consumption rainwater tank costs water pump costs water sewage electricity tariffs obtained five towns different values roof area number residents potable water demand rainwater demand analysed rainwater tank capacities estimated using netuno computer programme investment feasibility analysis performed considering ideal lower tank capacity well capacities smaller larger ideal capacities obtained according variation six months payback period observed ideal tank capacity conservative high rainwater demands cases investment feasibility analysis performed order obtain appropriate tank capacity main conclusion rainwater usage economically feasible cases higher rainwater demand higher feasibility
background treatment emergent mania hypomania tem possible adverse effect pharmacological non pharmacological antidepressant treatments objective performed systematic review meta analysis evaluate risk tem depressed patients randomized sham controlled trials rcts data sources medline database first date available august results references rcts identified described tem active sham groups respectively participants presented tem difference statistically significant also five additional reports tem participants rcts risk factors tem identified limitations low number studies tem reports conclusion despite previous reports active sham tdcs associated significantly greater number tem episodes elsevier inc rights reserved
artisanal gold mining galamsey cocoa farming essential sources income local populations ghana unfortunately former poses serious threats environment human health conflicts cocoa farming livelihoods timely spatially referenced information extent galamsey needed understand limit negative impacts mining address use multi date dmc satellite images map extent expansion galamsey map total area galamsey cocoa growing area using means clustering cloud free image strong spectral contrast galamsey surrounding vegetation also process pair hazy images multivariate alteration detection map galamsey expansion subset labelled change area use set visually interpreted random sample points compute bias corrected area estimates also delineate indicative impact zone pollution proportional density galamsey assuming maximum radius cocoa growing area ghana estimated total area galamsey impact zone change area galamsey tripled resulting direct encroachment protected forest reserves assuming growth rate rest cocoa growing area total area galamsey estimated galamsey developing along river network offln ankobra birim anum tano downstream pollution affecting land water elsevier rights reserved
alleviate environmental pollution improve efficient use energy energy systems integration esi covering electric power systems heat systems natural gas systems become important trend energy utilization traditional power flow calculation method object power system prove difficult meeting requirements coupled energy flow analysis paper proposes generalized energy flow gef analysis method suitable esi containing electricity heat gas subsystems first models electricity heat natural gas networks esi established view complexity conventional method solve gas network including compressor improved practical equivalent method adopted based different control modes basis hybrid method combining homotopy newton raphson algorithm executed compute nonlinear equations gef jacobi matrix reflecting coupling relationship multi energy derived considering grid connected mode island modes power system esi finally validity proposed method multi energy flow calculation analysis interacting characteristics verified using practical cases
paper current sensorless adaptive secondary side control proposed series resonant converter src making good candidate mhz voltage regulators means varying equivalent resistance output voltage regulation achieved controlling duty cycle synchronous mosfet taking advantage secondary side control srcs operate zero voltage switching input voltage load conditions current sensorless adaptive digital control proposed control current type synchronous mosfets automatically compensates delay caused current sensor circuit gate driver also eliminates current sensor power path hybrid control strategy introduced overcome efficiency degradation caused secondary side control
clinical studies indicate one third pregnant women psychotic symptoms exposed either typical atypical antipsychotic drugs apds reports prenatal subject model lacking hence present study undertaken investigate effect prenatal exposure risperidone ris fetal hippocampus related functional changes young rat offspring study pregnant wistar rats exposed equivalent therapeutic doses ris gestation days half pregnant subjects group euthanized fetuses collected fetal brains dissected processed neurohistopathological evaluation remaining pregnant dams allowed deliver naturally reared weeks age neurobehavioral study tinder selected paradigms cognition results indicate significant decrease thickness fetal hippocampus disturbed cytoarchitectural pattern volume striatum choroid plexus also reduced furthermore ris treated young rat offspring displayed memory impairment different mazes learning memory current study concludes maternal exposure clinically relevant doses ris may induce neurostructural changes developing hippocampus striatlitn cognitive sequelae young offspring respectively therefore caution must taken prescribing drug pregnant subjects especially sensitive phase brain development hence clinical correlation animal data urgently warranted elsevier inc rights reserved
backgroundpeople mental health disorders reported poorer access dental services poorer oral health outcomes aim paper analyze current published work regarding barriers enablers oral health outcomes access dental care adults mental health disorders addressed individual organizational systemic perspectives methodsa narrative review based search relevant published work regarding oral health people mental health disorders undertaken using medline web science eric psychlit relevant systematic reviews highlighted process along primary studies resultsthe published work repeatedly verified poorer oral health inadequate access dental services people mental health disorders published work identified barriers individual organizational systemic levels much published work focused barriers less focus enablers interventions conclusionsconsiderable investigation barriers elucidated options improve care outcomes
inmates serious mental illness smi antisocial personality disorder apd average higher rates disciplinary infractions inmates without conditions study builds upon lines research examining relationships among smi various types prison misconduct whether relationships moderated presence apd smi observed significantly related annual rates violent serious nonviolent misconduct apd moderated relationship smi serious nonviolent charges relationship smi violent charges implications inmate management classification practices aimed ameliorating misconduct discussed
building physical computing projects enable learners integrate computing range interests disciplines however electronic portion projects difficult students learning new concepts well work new tools influx information difficult students retain working memory construct circuits paper introduce bitblox set modular solderless breadboards prototyping circuits bitblox attempts decrease cognitive load user reducing complexity found standard breadboard bringing visibility underlying connections within modules present comparative classroom study integrating breadboard bitblox two different high school classes qualitative analysis focuses student errors strategies collaborative practices highlighting important dynamics designing hardware tools
common genetic disorder philadelphia negative chronic myeloproliferative neoplasms jak mutation present study aimed determine risk factors thrombosis patients essential thrombocytosis polycythemia vera screened medical records patients risk factors may predict thrombosis recorded venous thrombosis diagnosis significantly higher jak positive patients diagnosis similar jak positive negative groups significantly higher elderly patients treatment places importance jak mutation unmodifiable cardiovascular risk factors advanced age diagnosis
development solar energy conversion storage technologies attracting considerable attention recent years paper novel shape stabilized phase change material sspcm based stearic acid mesoporous hollow sio microspheres sio synthesized impregnating method mesoporous silica microspheres additional hollow cavity provide high loading capacity also favor free crystallization confined hollow microspheres interfacial interaction capillary action leakage obtained sspcms even temperature exceeds melting point sio pcm exhibits high latent heat reaching related thermal conductivity wmk enhanced relative pure moreover sio composites show excellent thermal stability beneficial latent heat thermal energy storage lhtes
active queue management aqm effective solution congestion control problem achieve high quality service qos reducing packet dropping probability network utilization three robust control algorithms proposed paper order design robust aqm schemes conventional controller robust particle swarm optimization pso based pid proportional integral derivative psopid controller robust ant colony optimization aco based pid acopid controller pso aco methods used tune pid controller parameters subject constraints achieve required robustness network robust psopid acopid controllers achieve desirable time response specifications simple design procedure low order controller comparison conventional controller wide ranges system parameters change used show robustness designed controllers ability designed controllers meet specified performance demonstrated using matlab mathworks inc apple hill drive natick usa hand verify effectiveness designed controller nonlinear simulation performed using package finally shown comparison proposed robust acopid achieve desirable performance psopid controller controllers proposed previous works institute electrical engineers japan published john wiley sons inc
present study refers building integrated solar thermal bist systems based vacuum tube collectors consists two parts first part literature review presented including studies vacuum tube technology vacuum tube bist systems environmental profile vacuum tube collectors etc critical issues example related integration vacuum tube collectors building highlighted review shows proposed vacuum tube bist concepts facade integration studies environmental profile vacuum tube collectors continuity issues presented first part second part includes case study environmental comparison vacuum tube bist system flat plate bist configuration based life cycle assessment systems gutter integrated patented developed tested university corsica france multiple life cycle impact assessment methodologies environmental indicators scenarios databases adopted results reveal energy payback time years flat plate bist vacuum tube bist respectively using recycling values become years respectively energy return investment greenhouse gas payback time avoided impact use phase adopting usetox ecological footprint france electricity well reference domestic gas boiler emissions also presented findings present work compared literature good agreement observed verify considerably higher impact avoided utilizing vacuum tube bist instead flat plate bist system elsevier ltd rights reserved
article authors propose test interactionist model personality functioning model maintains many traits function threshold like manner less situational strength needed evoke trait relevant response people high trait low trait different sensitivities people high trait reactive moderate provocation low trait opposite true strong provocation compared moderate provocation three studies reported showing model used understand nature aggression
heterocyclic carbene catalyzed addition aromatic aldehydes para quinone methides developed method could efficiently furnish diarylated ketones good high yields contain various functional groups
self reported substance use commonly used outcome measure treatment research evaluated validity self reported drug use sample adults mental health problems residing supportive housing programs primary analysis calculation positive predictive values ppvs self report compared oral fluid test taken time sensitivity analysis compared positive predictive values two self reported drug use histories biological testing window ranging past days depending drug type full past day comparison window maximum length recorded interview multivariable logistic regression used predict discordance self report drug test users self reported drug use oral fluid drug tests compared determine positive predictive value amphetamines methamphetamines pcp agreement cocaine agreement marijuana agreement drug tests participants misreported drug use likely older non white medical insurance report alcohol use general amphetamine methamphetamine pcp cocaine use adequately captured biological test marijuana use best captured combination self report biological data using full past day comparison window resulted higher concordance oral fluid drug test indicating self reported drug use past days may proxy drug use within biological testing window self report disadvantages used sole measure drug use population elsevier ltd rights reserved
rainwater harvesting increasingly viewed practical means reducing stormwater runoff supplementing water supply water scarce regions although widespread adoption limited urban areas number studies examined potential rainwater harvesting reduce potable water use stormwater runoff energy associated delivering potable water supplies associated costs none assessed costs benefits collectively using densely urbanized watershed southern california test case study quantifies economic benefits costs rainwater harvesting investigate whether capturing using rainwater efficient regional policy given watershed land use topography rainfall variability range cistern sizes evaluated estimate magnitude water energy carbon savings two rainwater use scenarios outdoor use outdoor plus non potable indoor use water prices held constant smallest cistern used outdoor irrigation efficient economic standpoint contrast modest annual increase water rates life project study shows rainwater capture outdoor use efficient policy cistern size finally due higher installation maintenance costs required pipe water indoors outdoor indoor uses show modest economic benefits potential volume water captured annually significant depending cistern size equivalent total water needs single family residences
wind generation systems require mechanisms allow optimal adaptation generator varying wind speed extract maximum energy wind robust affordable high performance methods also needed isolated sites paper takes approach switched reluctance generator used generator variable rotor speed although voltage obtained insufficient quality connect generator directly power grid kind generator used isolated sites charge battery bank simple bridge rectifier due nonlinear behavior machine position current along alternating nature current circulates phases machine experiences cyclical energy transformations mechanical electrical magnetic nature paper analyzes transformations purpose providing guidelines machine design optimization wind turbine isolated sites
paper combined steam organic rankine cycle proposed recover waste heat gas turbine proposed combined system includes subcritical steam rankine cycle coupled transcritical organic rankine cycle three different organic fluids selected monitor thermodynamic exergo economic performance system results show maximum exergy efficiency minimum total product cost rate studied system base case condition combined cycle respectively also parametric study performed investigate effects key parameters including steam turbine inlet pressure organic turbine inlet pressure organic preheater pinch temperature organic condensation temperature exergetic efficiency total product cost rate system finally genetic algorithm employed conduct multi objective optimization system two objective functions including exergy efficiency total product cost rate results optimization revealed combined cycle best performance thermodynamic exergo economic viewpoint among analyzed fluids elsevier ltd rights reserved
paper consider restricted data sharing set parties wish provide set online services requiring data sharing party assumed store data private relational databases given set mutually agreed set authorization rules specify access attributes individual relations joins relations owned one parties access restrictions introduce significant additional complexity rule enforcement query planning compared traditional distributed database environment examine problem minimum cost rule enforcement simultaneously checks enforceability rule generation minimum cost plan execution however paper focused specific cost functions instead efficient methods enforcing rules face access restrictions inter party data transfer needs propose efficient heuristic algorithm minimal enforcement since exact problem hard cases possible enforce rules regular parties cases need help trusted third parties tps parties trust single party enforce unenforced rules desirable use minimally also consider extended case multiple tps required since every regular party trust single
present new type broadband spectral spatial quasi optical decomposer microwave analog signal processing fully implemented substrate integrated waveguide siw technology input siw modulated couple energy near field focused surface wave inside hosting substrate due inherent spatially dispersive response focal point location varies frequency thus placing output siw ports appropriate positions focused signal extracted frequency providing instantaneous spectral decomposition design six output channels ghz insertion losses group delay swing illustrated experiments prototype reported prove feasibility proposed approach
background increasing prevalence obesity necessitated increasing use bariatric surgery adolescent population outcomes following laparoscopic sleeve gastrectomy lsg among adolescents however well studied report outcomes following lsg first line surgical therapy patients years age methods patients underwent lsg primary surgical option morbid obesity identified university illinois chicago standard clinicopathologic outcomes data recorded results identified patients females males underwent lsg mean patient age years mean bmi among patients differ gender one patient experienced day perioperative complication pulmonary embolism median los following lsg days iqr patients readmittedwithin days feeding intolerance resolved without invasive intervention median follow range months percent excess weight loss ewl among patients among patients least years follow ewl conclusions laparoscopic sleeve gastrectomy morbidly obese adolescents safe feasible option short long term weight loss appears successful following lsg lsg strongly considered primary surgical treatment option morbidly obese adolescents elsevier inc rights reserved
article examines detail quality doctor patient interaction doctor patient communication powerful indicator health care quality determine patients self management behavior health outcomes medical visit medical encounter plays pivotal role health care process fact doctor patient communication one essential dynamics health care affecting course patient care patient compliance recommendations care unlike many analyses often look one two specific aspects doctor patient relationships analysis encompassing looks doctor patient communication multiple perspectives
aim previously reported protective effect maternal omega fatty acid supplements development immunoglobulin ige associated disease infancy study assessed omega long chain polyunsaturated fatty acids lcpufa maternal milk relation omega lcpufa supplementation development allergic disease infants methods study randomised pregnant women risk allergic infant daily supplements omega lcpufa placebo soya bean oil gestational week months lactation breast milk samples collected colostrum one months milk fatty acids related allergic outcome infants months results omega milk fatty acids higher women received omega supplements placebo group higher proportions milk eicosapentaenoic acid docosahexaenoic acid lower arachidonic eicosapentaenoic acid ratio associated absence ige associated disease infants none children developed ige associated atopic eczema level mol eicosapentaenoic acid colostrum correction added july online publication preceding sentence correct word instead amended current version conclusion high omega lcpufa milk levels mothers received omega lcpufa supplements related fewer allergies children
hyperhomocysteinemia hhcys associated systolic heart failure however still unknown serum homocycsteine level useful predicting outcome patients diastolic dysfunction conducted cohort study determine hhcys associated poor prognosis diastolic dysfunction patients chin community cardiovascular cohort cccc study designated investigate trends cardiovascular morbidity mortality community individuals years enrolled participants categorized homocysteine concentration quartiles used multivariate cox proportional hazards models calculate hazard ratio quartiles versus quartile area receiver operating characteristic roc curve compare prediction measures total participants completed echocardiography examination individuals diagnosed diastolic dysfunction total participants died follow period hhcys found significantly associated poor prognosis adjusted homocysteine level confidence interval participants highest quartile trend fold risk cause death compared lowest quartiles using mol cut point hyperhomocysteine hhcys significantly associated poor prognosis diastolic dysfunction participants community
background aims chocolate consumption may beneficial effect cardiovascular health evidence prospective cohort studies still limited aimed examine prospective associations chocolate consumption risk stroke among men women large population based cohort methods total men women aged years free cardiovascular disease diabetes cancer baseline followed end respectively obtained data chocolate consumption participant using self administrated food frequency questionnaire included food beverage items cox proportional hazards regression models used estimate hazard ratios hrs stroke relation chocolate consumption results median follow years identified incident strokes cases cerebral infarctions hemorrhagic strokes adjustment age body mass index life styles dietary intakes risk factors chocolate consumption associated significant lower risk stroke women however association men significant addition association vary stroke subtypes either men women conclusions findings large japanese cohort supported significant inverse association chocolate consumption risk developing stroke women however residual confounding could excluded alternative explanation findings elsevier rights reserved
culturally prescribed social scripts traditional masculinity emphasize social dominance frequently linked diminished well men across variety psychological domains however studies examined role traditional masculinity scripts lives early adolescent boys girls despite relevance period potential developmental implications address need examined development early adolescents conformity traditional masculinity across middle school transition well links depressive symptoms academic engagement using diverse sample adolescents age female latina assessed beginning fall end spring first year middle school found increase conformity traditional masculinity scripts among boys among girls boys girls alike conformity traditional masculinity predicted greater depressive symptoms decreased academic engagement depressive symptoms also mediated association traditional masculinity academic engagement boys girls study among first study conformity traditional masculinity developmental lens findings suggest traditional masculinity scripts relevant early adolescents particularly boys transitioning middle school however boys girls conformity scripts compromise psychological academic well
image guided cancer radiation treatment three dimensional tumor volumetric information important treatment success however typically feasible image patient tumor continuously real time treatment due concern excessive patient radiation dose present new iterative morphing algorithm predict real time tumor volume based time resolved computed tomography dct acquired treatment offline iterative learning process designed derive target volumetric deformation function one breathing phase another real time volumetric prediction performed derive target volume treatment delivery proposed iterative deformable approach tumor volume morphing prediction based dct innovative makes three major contributions novel approach landmark selection tumor surfaces using minimum bounding box iterative morphing algorithm generate tumor volume using mapped landmarks online tumor volume prediction strategy based previously trained deformation functions utilizing dct experimental performance showed maximum morphing deviations original patient data artificially generated data promising newly developed algorithm implementation important applications treatment planning dose calculation treatment validation cancer radiation treatment
rapid timely evaluation urban environmental change highly important understanding urban sustainability china however comprehensive understanding urban environmental change china based multi source remote sensing data remains inadequate current studies mainly focused single aspect urban environment using specific source remote sensing data study developed comprehensive evaluation index cei combining remote sensing data fine particulate matter concentration land surface temperature vegetation cover assess urban environmental change china national scale among urban agglomerations across rapidly urbanized regions found trend environmental degradation urban areas china environmentally degraded moderately degraded urban areas accounted total urban area china particular expanded urban areas exhibited extensive environmental degradation total expanded urban areas exhibiting environmental degradation moderately environmental degradation increase concentration one main manifestations environmental degradation expanded urban areas suggest attention paid urban environmental issues future urban development china elsevier inc rights reserved
paper suggest using hybrid projection increase vertical geometric field view without incurring large deformations preserve distance perception allow seeing surrounding ground conducted experiment furnished unfurnished houses evaluate perception distances spatial comprehension results show hybrid projection improves perception surrounding ground leads improvement spatial comprehension moreover preserves perception distances sizes providing performance similar perspective one task distance estimation
south africa vibrant plastics manufacturing industry recycling limited insufficient notable proportion unmanaged waste entering environment south africa developing country microplastics research inception little known freshwater microplastics studies south african marine microplastics limited actively pursued water scarce country protection freshwater resources remains priority face socioeconomic issues poverty unemployment hiv aids receives insufficiently effective attention full impact risks microplastics pollution water yet discovered risks may enhanced developing country many communities remain largely dependent land natural waters south africa water scarce country quality aquatic resources even greater risk assumed increasing background microplastics emphasizing need research south african water research commission funded project undertaken derive research priorities immediate need improved recycling waste management integr environ assess manag setac
aim study determine difficulties regarding home care children following haematopoietic stem cell transplantation hsct sample study includes families children bone marrow transplant unit turkey data collected using form included descriptive information questions difficulties complications home care families telephoned problems encountered recorded mann whitney test logistic regression analysis used average age children years average age hsct performed average year hsct children underwent transplantation diagnoses anaemia primary physical problems found discharge hospital fever decreased appetite rash pain socially families reported children difficulties school primary difficulties regarding care follow reported skin care catheter care post transplantation period important provide information potential problems care patients families order increase quality life
aim early intervention prevention serious mental disorders bipolar disorder promise decreasing burden associated disorders increasing early preventive intervention efforts among cohorts familial risk bipolar disorder need examine associated ethical concerns aim review examine ethical issues underpinning clinical research pre onset identification preventive interventions bipolar disorder methods undertook pubmed search updated november incorporating search terms bipolar mania hypomania ethic truncated early intervention prevention genetic family results fifty six articles identified method well relevant articles examined within framework ethical principles including beneficence nonmaleficence respect autonomy justice primary risks associated research clinical interventions include stigma labelling especially among familial high risk youth side effects interventions another concern benefits preventive early interventions amelioration symptoms well possibility minimizing disability cognitive impairment progression illness supporting autonomy individuals improving access stigma free care may help moderate potential challenges associated risks interventions conclusions concerns risks early identification pre onset interventions balanced potential benefits individuals right choice improving availability services balance dilemmas
study explores relationship bar occupational personality questionnaire opqi determine link self reported emotional intelligence personality traits data obtained managers working finance sectors included multi source measures emotional intelligence results indicated construct overlap correlations elements emotional intelligence opqi stronger relationship measures emotional intelligence personality self report measure measure mood scale showed strongest link personality factors measures emotional intelligence include component may thus provide useful indicator individual ability manage feelings others
report design implementation testing instrument rapid dry rubber content drc determination rubber latex composed rectangular waveguide antennae microwave generator power detector microcontroller according theory microwave transmission power loss microwaves passing latex related drc attenuation determined measuring transmitted microwave intensity power detector appropriate frequency gives best correlation drc attenuation found ghz microwave power measurement processed microcontroller using empirical calibration equation estimate drc rubber latex instrument tested using new latex samples various drc sampled locally songkhla province thailand drc estimates instrument compared slow accurate standard oven drying results estimates mean error indicating good practical performance
endogenous alcohol applied spontaneous ethanol production via different metabolic pathways human body auto brewery syndrome describes patients alcohol intoxication ingesting carbohydrate rich meals main objective study investigate effect diabetes mellitus liver cirrhosis presence blood alcohol concentration bac especially carbohydrate ingestion bac measured headspace gas chromatography mass spectrometry three groups humans namely control groups results showed bac control group mean patients bac significantly higher control group patients bac patients bac increases reach endogenous ethanol production appears increase also increased much patients diseases reach toxic levels comparing bac blood glucose level group groups show insignificant correlations
paper present theoretical analysis model reduction algorithm linear switched systems shaker wisniewski algorithm reminiscence balanced truncation method linear parameter varying systems wood specifically paper provide bound approximation error norm continuous time norm discrete time linear switched systems provide system theoretic interpretation grammians singular values furthermore show performance balanced truncation depends input output map choice state space representation class stable discrete time linear switched systems called strongly stable systems define nice controllability nice observability grammians genuinely related reachability controllability switched systems addition show quadratic stability lmi estimates gains depend input output map elsevier ltd rights reserved
post concussion impairments may result unsafe driving performance little research available guide consensus concussed individuals return driving purpose study compare driving performance individuals without concussion explore relationships neuropsychological driving performance fourteen participants concussion age years old non concussed age driving experience matched controls age years old completed graded symptom checklist brief neuropsychological exam driving simulation task participants concussion completed driving simulation within becoming asymptomatic days post concussion one way analyses variance used compare total number crashes tickets lane excursions well standard deviation lateral position sdlp standard deviation speed pearson correlations conducted explore relationship neuropsychological driving performance separately group participants concussion committed frequent lane excursions concussed controls exhibited greater sdlp compared controls first curve concussed controls final curve concussed controls poorer performance symbol digit modalities rey osterrieth complex figure verbal memory motor speed correlated frequent lane excursions concussed group control group despite asymptomatic concussed participants exhibited poorer vehicle control especially navigating curves driving impairments may persist beyond individuals concussion returned driving study provides preliminary guidance regarding neuropsychological functions may best indicate driving impairment following concussion
principle minimum absorbed power pmp defined demonstrated fundamental electrical circuits stationary quasi stationary regime imposing pmp natural conditions result kirchhoff current law kcl nodal method first aim paper propose new formulation basic forms circuit equations substituting kcl equations pmp equations furthermore paper proves existence pmp maximum power transfer theorem mptt one basic concepts electrical circuit theory considerations extrapolated demonstrated natural sequel linear magnetic circuits quasi stationary state considering equivalence electrical circuits case imposing conditions principle minimum absorbed energy pme one proves equations kirchhoff fascicular fluxes law kfl nodal method magnetic circuits nmm achieved numerical examples presented hereinafter refer classical linear electric magnetic circuits quasi stationary state prove originality theoretical concepts introduced
developing factory future objective graduate school excellence advanced manufacturing engineering gsame stuttgart achieve goal several research areas concerning factory future exist example strategies factories development information communication manufacturing material process engineering management global manufacturing networks one specific research project within area management global manufacturing networks global manufacturing networks software intensive service providers started december research project deals questions factory future able satisfy increasing need information communication technology ict future compose different ict services integrated existing global manufacturing network second step contribution hand considers motivation relevance research objective research project
background million americans living chronic pain pain common reason patients seek medical attention despite prevalence pain practice pain management scientific discipline pain research relatively new fields compared rest medicine contributing twenty first century dilemma health care providers asked relieve suffering fifth vital sign era methods manuscript provides narrative review basic mechanisms chronic pain history chronic pain management united states including various regulatory health system provider factors contributed decline multidisciplinary pain treatment favor predominant opioid treatment strategy seen today multiple non opioid pain treatment strategies outlined manuscript concludes three key questions help guide future research intersection pain addiction conclusions assessment treatment chronic pain continue one common functions health care provider move beyond reliance opioid medications addiction pain research communities must unite chronic pain patients increase evidence base supporting non opioid analgesic strategies author published elsevier ireland ltd
consider new type attack coherent quantum key distribution protocol coherent one way cow protocol main idea attack consists measuring individually intercepted states sending rest unchanged calculated optimum values attack parameters arbitrary length communication channel compared novel attack standard beam splitting attack
using single crack solution regular plane harmonic function saint venant bending problem cracked cylinder general cross section formulated terms two sets boundary singular integral equations solved using methods combination boundary element singular integral equation methods concept bending center used strength materials extended bending problem theoretical formulae calculate bending center stress intensity factors cracked cylinder derived expressed solutions integral equations based results numerical examples given different configurations cylinder cross section well crack parameters
order ensure successful mating opportunities critical human perceivers accurately infer others sexual interests perceivers achieve inferences years scientists documented pupils dilate response sexual arousal despite potential importance cue mate selection however extant data focused almost exclusively perspective individual experiencing arousal demonstrate outside observers exploit pupil dilation visible cue others sexual interests used reverse correlation methods derive facial images based perceivers mental representations state based sexually aroused sexually unaroused trait based sexually promiscuous sexually non promiscuous markers sexual interest next explored phenotypic features differentiated faces specifically dilation pupils contained within reverse correlation image consistent notion pupil dilation reliable cue sexual arousal sexually interested faces contained objectively larger darker pupils sexually disinterested faces moreover differences perceptually obvious naive observers collectively results suggest perceivers attend external cue pupil dilation forming decisions others state based trait based sexual interests elsevier inc rights reserved
domain specific self concepts good mathematics general school self concepts good school shown good predictors academic performance persistence even well yet research predictors domain general cross curricular nonacademic self concepts good solving problems scarce basis generalized internal external frame reference model model study tested potential predictors domain general problem solving self concept structural equation models revealed line model self reported mathematics achievement complex problem solving exerted assimilation effects problem solving self concept expected relations self reported verbal achievement also found high association mathematics verbal problem solving self concepts simultaneous control school track general fluid ability assessed using fair subscales cft classification matrices typologies decreased association complex problem solving problem solving self concept discuss possible impact domain general self concepts students performance elsevier inc rights reserved
energy harvesting established field linear equivalent circuit models single multiple degree freedom systems routinely used assess energy harvesting efficiency various interface electronic circuits however field energy harvesting moves toward complex systems nonlinear energy harvesting fluidic energy harvesting modified equivalent circuits required effectively capture behavior devices article presents two general methods system level approach dependent source equivalent approach adequately model behavior advanced harvesters approaches also easily used model single multiple degree freedom linear harvesters equivalent circuits piezoelectric electromagnetic harvesters discussed four case studies presented illustrate application equivalent circuit approaches including following piezoelectric duffing harvester electromagnetic duffing harvester simplified aeroelastic harvester piezoelectric duffing harvester rectifier circuit
paper presents new cmos realization copy current differencing buffered amplifier cdba recently reported active element especially suitable analog signal processing applications new current mode filter topology proposed application example order demonstrate performance cdba proposed cdba circuit designed based current differencing unit cdu third generation current conveyor cciii voltage buffer third generation current conveyor cciii used duplicate terminal current performance cdba verified pspice bsim level spice parameters used simulations
paper literature review characterized questions open closed later teaching strategy allows high school students learn ask open ended questions designed strategy included lectures experiments visits finally carried intervention various groups results show possible teach ask open ended questions characterize scientific thinking skills
thermal acoustic energy converter tac developed tested produce sound waves kilohertz range directly solar energy converter consisted glass window small amount steel wool shape disk sealed aluminum housing fresnel lens chopper wheel holes employed generate pulsed sunbeam approximately sun intensity heat source tac various designs techniques tested improve sound amplitude signal noise ratio converter high frequencies reduction air volume better cooling improvement air tightness found effective enhancing sound amplitude shockproof mount commonly used radio studios reduce microphone vibration essential noise reduction tac high chopper wheel rotations sound amplitude found rapidly decrease increase pulse frequency sunbeam low frequencies relationship decibel value frequency generated sound waves changed linear sunbeam frequencies khz frequency penetration surface temperature fluctuations aluminum housing becomes comparable aluminum housing thickness given frequency sound amplitude increased almost exponentially increase solar flux intensity best knowledge khz sound frequency measured experiments far highest frequency produced solar acoustical energy converter
background quercetin well known flavonoid pharmacokinetic interaction ester drugs due capability esterase inhibition gut liver however interaction quercetin nanoparticles nqc rivastigmine reported hence present study performed evaluate effect quercetin alone nanoparticles pharmacokinetics rivastigmine rats methods nqc prepared antisolvent precipitation method influence quercetin pharmacokinetics rivastigmine evaluated following methods vitro inhibitory effect esterase enzyme rat liver microsomes vitro assessment cypa activity using erythromycin demethylase emd assay confirm findings vivo pharmacokinetic study orally administered rivastigmine rats quercetin nqc pretreatments performed results size nqc observed quercetin significantly inhibited esterase mediated metabolism rivastigmine vitro assessment cypa activity model erythromycin demethylation emd levels quercetin treated group significantly reduced cmax auc auc rivastigmine found increased quercetin nqc pretreated groups rivastigmine significantly decreased conclusions results revealed enhanced bioavailability rivastigmine might caused combination effects due cypa esterase inhibition therefore concomitant administration nqc influences bioavailability rivastigmine also synergetic effect treatment alzheimer disease institute pharmacology polish academy sciences published elsevier rights reserved
objective investigate effect local hil gene therapy experimental periodontitis rats elucidate mechanism underlying effect material methods experimental periodontitis induced ovariectomized ovx rats using silk ligature injected hil plasmid liposomes vector plasmid liposomes palatal side gingival mucosa upper left second molar every two days rats killed hours seventh injection body weight bone mineral density whole body pelvis spine resorption alveolar bone number cytokine positive cells measured determine effects hil periodontal tissue results hil expressed periodontal tissues local gene delivery expressed hil protein inhibited alveolar bone resorption downregulated tnf rankl mmp periodontal ligament root furcation region conclusions local hil gene transfer suppressed alveolar bone resorption ovx rats effect probably associated decline expression pro inflammatory cytokines periodontal tissues
human population xxi century struggling increasing incidence diseases obesity diabetes cancers food allergies many others recent studies shown oxidative stress caused reactive oxygen species free radicals may underlie occurrence many diseases probiotics known beneficial effects health established dietary adjuncts researchers trying find potential probiotic strains exhibit antioxidant properties along health benefits vitro vivo studies indicated probiotics exhibit antioxidant potential also many studies shown consumption probiotics dietary supplements may reduce oxidative damage modify activity crucial antioxidative enzymes human cells incorporation probiotics foods provide good strategy supply dietary antioxidants studies needed standardize methods evaluate antioxidant properties probiotics recommended antioxidant potential paper presents latest news related probiotics antioxidative potential
angina pectoris symptomatic manifestation transient myocardial ischaemia fundamental level angina arises myocardial oxygen demand exceeds ability coronary circulation provide adequate oxygen delivery maintain normal myocardial metabolic function vivo balance oxygen demand delivery complex physiological process altered variety interventions lifestyle modification cornerstone cardiovascular disease management without angina additional pharmaceutical physical interventions usually applied patients angina mechanisms action interventions include heart rate modulation vascular smooth muscle relaxation metabolic manipulation revascularization others number interventions overlapping mechanisms target angina additionally interventions may directly indirectly prevent delay adverse outcomes myocardial infarction death review summarizes current evidence many applied ischaemia treatments documented modify angina comments available evidence relating improvement cardiovascular outcomes
transformer less dual input dual output dido converter proposed paper converter finds application fields hybrid power system hybridization energy sources electric vehicles supply output loads charging discharging battery energy storage system made fuel cells photo voltaic provided primary source four switches controls converter operation design duties provided multiple output voltage levels obtained deliver power electric motor lighting loads association electric vehicle applications converter simulated using matlab simulink simulation results validates operability converter
objective study focuses occurrence musculoskeletal disorders children presented general practice known epidemiological studies addressing musculoskeletal diseases childhood scarce based low number episodes design setting prospective study patient contacts general practice total number general practitioners participated divided four groups registering four consecutive three month periods patients children younger years age visited registration period diagnoses working hypotheses concerning musculoskeletal disorders selected results total number children study disorders musculoskeletal system accounted contacts episodes episodes registered icpc chapter musculoskeletal new episodes presented fifty four percent new episodes acute injuries new episodes general practitioner made symptom diagnosis differences age sex found limited number diagnosis categories conclusion children present disorders musculoskeletal system less often adults also present different disorders general practitioners majority disorders presented children acute injuries mostly sprains strains
paper supervised adaptive learning based fuzzy controller alfc neural network identification convex parameterization designed identify control unmanned vehicle autonomous parking system objective achieve robust learning control maintaining low implementation cost proposed algorithm design incorporates following learning control theorems non linear system identification using neural network fuzzy logic supervised adaptive learning well multiple model based convex parameterization demonstrate algorithm straight forward manner using real nonlinear unmanned autonomous driving system example apply algorithm showing superior performance controller autonomous driving system proposed method used estimating controlling desired vehicle speed steering wheel turning supervised adaptive learning based method robustness also assured various operating environments regardless unpredictable disturbances convex parameterization improves speed convergence adaptive learning process fuzzy controller using multiple models concept last least comparative experiments also demonstrated systems equipped new algorithm able achieve faster smoother convergence
objective randomised controlled trials open label extension studies demonstrated clinical efficacy safety tumour necrosis factor alpha tnf alpha blocking therapy pre selected study patients ankylosing spondylitis aim investigate year drug survival clinical effectiveness etanercept treatment patients daily clinical practice methods consecutive patients prospective observational glas cohort started etanercept active disease included evaluated years according fixed protocol continuation treatment based basdai improvement expert opinion results included patients still using etanercept years follow reasons treatment discontinuation adverse events inefficacy reasons although good clinical response etanercept treatment resulted rapid weeks sustained improvement disease activity basdai asdas crp physician gda spinal mobility physical function basfi quality life asqol extra spinal manifestations swollen joints tender joints tender entheses furthermore concomitant nsaid dmard use decreased significantly follow years low disease activity remission present patients respectively patients discontinued etanercept switched successfully second third tnf blocker follow conclusion large cohort patients treated etanercept approximately continued treatment years broad evaluation clinical endpoints proves long term effectiveness etanercept treatment daily clinical practice
alzheimer disease devastating progressive neurodegenerative disease characterized pathologically accumulation amyloid beta beta hyperphosphorylation tau proteins brain deposition beta aggregates triggers synaptic dysfunction hyperphosphorylation tau neurodegeneration lead cognitive disorders investigated neuroprotective effect fisetin beta mouse model single intracerebroventricular injections beta min mouse markedly induced memory synaptic deficits neuroinflammation neurodegeneration intraperitoneal injections fisetin dose day weeks starting beta injection significantly decreased beta induced accumulation beta bace expression hyperphosphorylation tau protein serine fisetin treatment also markedly reversed beta induced synaptic dysfunction increasing levels presynaptic syn snap postsynaptic proteins psd snap glur ser creb ser camkii thr ultimately improved mouse memory observed morris water maze test fisetin significantly activated pik akt ser gsk beta ser expression beta treated mice moreover fisetin prevented neuroinflammation suppressing various activated neuroinflammatory mediators gliosis also suppressed apoptotic neurodegeneration triggered beta injections mouse hippocampus fluorojade immunohistochemical staining caspase revealed fisetin prevented neurodegeneration beta treated mice results suggest fisetin potent neuroprotective effect beta induced neurotoxicity results demonstrate polyphenolic flavonoids fisetin could beneficial effective safe neuroprotective agent preventing neurological disorders
cohort study conducted examine association low carbohydrate diet lcd score risk incident metabolic syndrome mets components years follow healthy adults within framework tehran lipid glucose study lcd calculated according intakes carbohydrate monounsaturated fatty acids refined grains vegetable protein fiber polyunsaturated fatty acids ratio glycemic load using food frequency questionnaire baseline final model adjustment age gender smoking status physical activity energy intake significant association lcd score fasting plasma glucose beta triglycerides tgs beta beta bmi beta mets risk scores beta conclusion lcd may associated decreased risk mets components adults
paper design fabrication electromagnetic characterization wide band dielectric absorbers based carbon fibers polyaniline powder presented fabricated absorbers characterized using free space measurement system fsms band frequency region return loss maxima absorption ghz achieved minimum absorption throughout band frequency region proposed fabricated absorber density thickness appears potential candidate stealth technology
purpose aim provide detailed mechanical metallurgical examinations ion nitrided austenitic stainless steels design methodology approach austenitic stainless steel material chosen present study ion nitriding process applied fatigue tensile samples prepared machining process temperature degrees treatment time period tensile fatigue notch impact hardness tests applied metallographic examinations performed findings high temperature longer treatment ion nitriding decreased fatigue tensile strengths together notch impact toughness scanning electron microscopy energy dispersive ray spectroscopy analysis revealed formation nitrides sample surfaces surface hardness increased increase process time due diffusion nitrogen ion nitriding research limitations implications would interesting search different temperature time intervals ion nitriding could good idea future work could concentrated ion nitriding welded stainless steels practical implications surfaces mechanical parts exposed higher stress abrasive forces compared inside mechanical parts time period mechanical components carry expected functions stresses forces exceed surface strength limit material cracks begin form material surface leading abrasion corrosion therefore surface strength materials needs increased provide longer service life ion plasma nitriding possible remedy surface wear originality value main value paper contribute fulfil detailed mechanical metallurgical examinations ion nitrided austenitic stainless steels studied far literature
monitoring turbidity surface suspended sediment concentration sssc inland waters essential address several important issues erosion sediment transport deposition throughout watersheds reservoir siltation water pollution human health risks etc especially important regions limited conventional monitoring capacities west africa study explore use moderate resolution imaging spectroradiometer data modis modoq mydoq products red near infrared nir bands monitor turbidity sssc bagre reservoir burkina faso high values parameters associated high spatial temporal variability potentially challenge methodologies developed far less turbid waters field measurements turbidity sssc radiometry used evaluate different radiometric indices nir ratio found suited retrieve sssc turbidity situ spectoradiometer measurements satellite reflectance modis spatio temporal variability modis nir together rainfall estimated tropical rainforest measuring mission trmm altimetry data jason analyzed bagre reservoir period found rain events early rainy season february march mid rainy season august decisive triggering turbidity increase sediment transport observed reservoir upstream downstream june september furthermore significant increase turbidity values observed mainly july december period especially well marked august central downstream areas showing largest increase probable hypothesis explain evolution change land use particularly increase amount bare soils enhances particle transport runoff elsevier rights reserved
electric machines designs traction applications concerned high power density high efficiency low manufacturing cost order achieve better combination parameters satisfy machine electromagnetics mechanical thermal designs limitations optimization algorithm necessary therefore work focuses comparing two optimization algorithms utilized search optimal solution design brushless permanent magnet blpm motor target machine design meet freedomcar specifications detailed uqm technologies inc paper relatively new modern evolutionary optimization technique known bees algorithm employed search optimum design parameters according pre defined multiobjective function results compared results obtained genetic algorithm therefore optimization methods compared terms computational efficiency ability find optimal solution blpm however comparison results show better computational ability search optimal parameters achieves lower average value objective function
three dimensional vision based scanning metrology inspection applications area attracted increasing interest industry interest driven recent advances technologies enable high precision measurements affordable cost vision allows modelling inspection visible surface objects necessary detect subsurface defects active infrared thermography one commonly used tools today non destructive testing evaluation ndt materials fusion two modalities allows simultaneous detection surface subsurface defects visualisation defects overlaid model scanned modelled parts computer aided design cad work present framework automatically fusing data scanned cad infrared thermal images ndt process space captured images thermal infrared counterparts aligned fused using automatically detected features fusion undergone space thus allowing visualisation subsurface defects model cad additionally defects extracted using image processing techniques overlaid virtual position space positioning certain distance part surface proportional computed depth using phase image analysis fourier domain depth represents real position detected subsurface defect extracted using thermograms temporal sequence thermal images results obtained promising show new technology used efficiently combined ndt metrology analysis manufactured parts areas aerospace automotive among others
problem research strategy findings form based codes fbcs definition put emphasis built form characteristics traditional zoning codes several municipalities adopting fbcs alternative euclidean traditional zoning codes achieve certain objectives however extent codes differ integrating important planning design criteria examined use case study method evaluate extent fbcs adopted city miami miami compared city previous code ordinance reflects leadership energy environmental design neighborhood development leed criteria evaluate contents codes point scale concordance leed criteria results indicate miami generally goes beyond ordinance reflecting leed criteria however important criteria mixed income diverse communities certified green building deserve attention miami takeaway practice planners municipalities seeking alternatives traditional zoning code consider replacing fbc also integrate planning principles leed incorporates strengthen proposed code benefit findings study determining extent certain built form characteristics leed criteria emphasized choosing appropriate alternative traditional zoning codes
background pleiotrophin ptn cytokine found highly upregulated brain different disorders characterized overt neuroinflammation neurodegenerative diseases drug addiction traumatic injury ischemia present work explored whether ptn modulates neuroinflammation toll like receptor tlr crucial initiation immune response involved methods immunohistochemistry assays studied lipopolysaccharide lps induced changes glial fibrillary acidic protein gfap astrocyte marker ionized calcium binding adaptor molecule iba microglia marker expression prefrontal cortex pfc striatum mice transgenic ptn overexpression brain ptn wild type mice cytokine protein levels assessed pfc map technology influence tlr signaling lps effects genotypes assessed pretreatment tlr antagonist tak murine microglial cells treated ptn lps assessed release nitric oxide results found lps induced microglial activation significantly increased pfc ptn mice compared mice levels tnf alpha mcp response lps significantly increased pfc ptn mice compared mice pretreatment tak efficiently blocked increases cytokine contents similar manner genotypes concomitant incubation cells lps ptn significantly potentiated production compared cells treated lps conclusions findings identify first time ptn novel potent regulator neuroinflammation pleiotrophin potentiates lps stimulated microglia activation results suggest regulation ptn signaling pathways may constitute new therapeutic opportunities particularly neurological disorders characterized increased ptn cerebral levels neuroinflammation
airborne wind turbines awt represent radically new fascinating concept future harnessing wind power concept consists realizing blades conventional wind turbine cwt form power kite flying high speed perpendicular wind kite mounted turbine electrical generator power electronics converter electric power generated transmitted via medium voltage cable ground high flight speed power kite several times actual wind speed small swept area turbine required according betz law turbine low weight generation given electric power moreover high turbine rotational speed gear transmission necessary size generator also reduced takeoff landing power kite turbines act propellers generators motors electric power supplied system maneuvered like helicopter present work configuration power electronics converters implementation awt considered major aspect trade power weight ratio efficiency dependence cable weight cable losses voltage level power transmission investigated comparison made low voltage medium voltage versions generators furthermore interdependence weight efficiency bidirectional dual active bridge converter coupling rectified output voltage generator cable discussed based concept offering best possible compromise weight efficiency power electronics system selected model control behavior derived power flow directions control structure proposed dimensioned furthermore questions electromagnetic compatibility electrical safety treated conclusion essential results work summarized outlook future research given enable reader make simplified calculations comparison cwt awt aerodynamic fundamentals systems summarized highly simplified form appendix numerical values given system discussed work
effects pornography whether violent non violent sexual aggression debated decades current review examines evidence influence pornography sexual aggression correlational experimental studies real world violent crime data evidence causal relationship exposure pornography sexual aggression slim may certain times exaggerated politicians pressure groups social scientists debate focused violent pornography evidence negative effects inconsistent violent pornography comparatively rare real world victimization rates rape united states demonstrate inverse relationship pornography consumption rape rates data nations suggested similar relationships although data used determine pornography cathartic effect rape behavior combined weak evidence support negative causal hypotheses scientific literature concluded time discard hypothesis pornography contributes increased sexual assault behavior elsevier ltd rights reserved
model predictive control mpc potential control technique nonlinear systems also control mimo system treat constraints easily however mpc disadvantage big computational cost mpc successfully applied chemical industry sampling period sufficiently large several tens second longer however mpc suitable mechanical systems controlled sampling period order milliseconds paper feedback compensation method discrete nonlinear systems proposed overcome problem verify effectiveness proposed method discrete time identified engine model used simulation shown computational time proposed method faster conventional method gmres
objective dermatophytosis frequent fungal infection world frequency constantly increasing aim study evaluate clinical features epidemiological trends dermatophytosis years tehran iran patients methods total patients clinically suspected cutaneous fungal infections examined skin scales plucked hairs nail clippings sub ungual debris examined direct microscopy culture dermatophyte species identified species level combination morphological physiological criteria results direct microscopy confirmed contamination rate cases cases culture positive distributed male cases female cases commonly infected age group years old tinea pedis prevalent type dermatophytosis followed tinea cruris tinea corporis epidermophyton floccosum prevalent causative agent followed trichophyton rubrum trichophyton mentagrophytes conclusion results showed considerable distribution dermatophytosis zoophilic anthropophilic geophilic species among population diverse age groups although anthropophilic fungi mentagrophytes floccosum rubrum main etiologic agents dermatophytosis prevalence verrucosum showed meaningful increase years highlights importance rural dermatophytosis mainly transmitted large animals noticeable information improves current knowledge dermatophytosis assists establish effective prevention therapeutic strategies overcome disease elsevier masson sas rights reserved
rapid urbanization constant expansion urban areas last decades locally led increasing water shortage rainwater harvesting rwh systems potential important contributor urban water self sufficiency goal study select environmentally optimal rwh strategy newly constructed residential buildings linked rainwater demand laundry mediterranean climatic conditions without accounting water mains different strategies environmentally assessed design use rwh infrastructures residential apartment blocks mediterranean climates harvested rainwater used laundry strategies strategies accounted tank location tank distributed roof underground tank building height considering number stories iii distribution strategy shared laundry supply nearest apartments distribution throughout building rwh systems consisted catchment storage distribution stages structural hydraulic calculations based mediterranean conditions quantification environmental performance strategy emissions performed accordance life cycle assessment methodology according environmental assessment tank location distribution strategy chosen important variables optimization rwh systems roof tank strategies present fewer impacts underground tank equivalents enhance energy material savings reinforcement requirements accounted within safety factors building structure without tank among roof tanks depending height distribution strategy concentrates demand laundry room preferable option resulting reductions selected impact categories compared distribution throughout building results may set new urban planning standards design construction buildings perspective sustainable water management sense behavioral change regarding demand promoted compact dense urban settlements
sleep disturbances hyperactivity prevalent several neurodevelopmental disorders including autism spectrum disorders asds attention deficit hyperactivity disorder adhd evidence genome wide association studies indicates chromosomal copy number variations cnvs associated increased prevalence neurodevelopmental disorders particular cnvs chromosomal region profoundly increase risk asd adhd disorders common males females hypothesized mice hemizygous deletion del would exhibit sex specific sleep activity alterations test hypothesis recorded activity patterns using infrared beam breaks home cage adult male female del wildtype littermates comparison controls found male female del mice exhibited robust home cage hyperactivity additional experiments sleep assessed polysomnography period del male female mice exhibited significantly time awake significantly less time non rapid eye movement nrem sleep period wildtype littermates analysis bouts sleep wakefulness revealed del males females spent significantly greater proportion wake time long bouts consolidated wakefulness greater min duration compared controls changes hyperactivity wake time wake time distribution males resemble sleep disturbances observed human asd adhd patients suggesting del mouse model may useful genetic model studying sleep activity problems human neurodevelopmental disorders autism res international society autism research wiley periodicals inc autism res international society autism research wiley periodicals inc
general current difference due immunoreactions significant determining biosensor sensitivity work new strategy triple sensitivity amplification ultrasensitive electrochemical detection prostate specific antigen psa developed poly methylene blue pmb implemented redox species strong current signal used fabricate substrate biosensor conductive reduced graphene oxide nanocomposites rgo coated pmb modified glassy carbon electrode gce amplify current signal peptides cehssklqlak fixed rgo aupmb gce fixed peptides reacted glutaraldehyde immobilize polydopamine horse radish peroxidase nanocomposites pda hrp electrochemical sensing interface psa realized due smaller resistance compared antibodies peptides cleaved specifically psa employed incubation psa large obtained behaved decrease current signal remaining pda hrp accelerated enzyme catalyzed precipitation reaction chloro naphthol decrease current signal namely increase delta resulted poorly conductive precipitation adhering onto biosensor designed biosensor presented wide linear range ngml ultralow detection limit
new method reliability monitoring electrical devices based carbon fibres presented due thermo mechanical stress electronic circuits loss fibre network integrity take place potential difference may appear edges broken carbon fibres potential difference causes intensive field emission surfaces broken carbon fibres acceleration emitted electrons due acceleration electrons microwave emission generated cfrp used simulate behaviour carbon based electronic device sequence microwave impulses detected frequency bandwidth ghz rise time detected microwave impulses nanoseconds time agreement crack formation time carbon fibre correlation change electrical resistance composites microwave impulses fibres fracture observed thus breakdown current flows carbon fibres induces detectable microwave emission means defects electrical circuits wireless detected online
lap time simulation one powerful tools evaluating design proposals motorsport engineering particular transient simulations play important role ultimate accurate approach static quasi steady state methodologies paper first method transform differential equations system formally linear continuous discrete state space representation particularised seven degree freedom suspension transient cornering model proposed use time variant coefficients matrices model allow non linear time variant characteristics systems described second case transient cornering model representation translated transfer function order apply discrete control strategy finite time strategy predictive strategy adaptive ideal driver found calculation methodology described successfully applied acceptable degree accuracy according comparison results using mechanical numerical software adams simulink also observed use curvature track reference control closed loop sufficiently accurate force car follow target path closely furthermore predictive control finite time control including integration provide excellent results smooth response steering input many lap time simulators language specific however methodology proposed paper run programming languages
background know whether differences exist residual effect chlorhexidine isopropyl alcohol compared triclosan isopropyl alcohol methods using analytic longitudinal controlled comparative experimental trial blinded measurements recruited healthy adult volunteers university guanajuato completed stabilization phase skin microbiota history skin allergies four areas inner surface forearms designated study unscrubbed control establishing baseline bacterial counts scrubbed control tridistilled water scrubbed chlorhexidine scrubbed triclosan quantitative cultures taken areas hours using agar plates neutralizing agents results total healthy volunteers tested hours unscrubbed control counts cfu whereas scrubbed control counts cfu cfu chlorhexidine cfu triclosan kruskal wallis chi conclusions chlorhexidine best antiseptic option prolonged antiseptic effect needed instance implanting medical devices performing surgical procedures association professionals infection control epidemiology inc published elsevier inc rights reserved
instances widespread conflict mass atrocities socially prescribed perpetuated gender roles often begin dissolve alongside rule law state institutions mass violence tears social fabric community accepted norms gendered behavior suspended recent conflicts including genocide rwanda created temporary space inclusion women previously restricted public spheres capacities rwanda stands unique changes temporary following end genocide rwanda state organs nongovernmental organizations community members close public spaces advocate return girls women pre genocide gender structures patriarchal practices paper analyze rwanda gender mainstreaming gender equality initiatives identifying three influential factors make recommendations replication rwanda success post conflict countries
rio san giorgio iglesiente sardinia italy stream affected abandoned mine wastes characterized dense vegetation streambed mainly comprised phragmites australis juncus acutus vegetation creates natural biogeochemical barriers drive mineralization processes attenuate metals load stream several techniques covering scales micrometres kilometres applied investigate biogeochemical processes water chemistry injected hydrologic tracer mineralogy microscopic investigation ray spectroscopy multiscale multimethod approach recognized two predominant sets biogeochemical processes microbially driven metal sulphide precipitation mainly resulting pyrite formation plant uptake metals leads formation iron oxide hydroxide incorporation within roots aerial part stem leaves dense vegetation rio san giorgio streambed controls morphology velocity streamflow reflected observed bromide tracer loss enhanced water exchange streambed hyporheic zone combined effect vegetative controls establish biogeochemical barriers greatly retard trace metal mobility hyporheic zone estimated effect lead apparent decrease load elsevier ltd rights reserved
lush gardens gleaming cars surround mumbai middle class apartment buildings hint plentiful water supplies however piped mains water supplied hours per day research explores pragmatic choreography water sources produce constant supply middle class households respond limited municipal water supply use mains water storage tanks wells water trucks packaged water rainwater harvesting portfolio water supplies involves various actors important instance domestic service production article suggests introducing rainwater harvesting creates opportunities water use households allows reconsideration water provision governance citywide
airway remodeling resultant complex multicellular response associated progressive decline pulmonary function patients chronic airway disease repeated infections respiratory viruses linked airway remodeling largely unknown mechanisms although acute activation toll like receptor tlr pathway extracellular polyinosinic polycytidylic acid poly induces innate signaling kappa transcription factor normal human small airway epithelial cells prolonged repetitive tonic poly stimulation produces chronic stress fiber formation mesenchymal transition activation fibrotic program chronic poly stimulation enhanced expression core mesenchymal regulators snail family zinc finger zinc finger box binding homeobox mesenchymal intermediate filaments vimentin extracellular matrix proteins fibronectin collagen mesenchymal transition prevented silencing expression kappa rela administration small molecule inhibitor kappa kinase bms acute poly exposure vivo induced profound neutrophilic airway inflammation administered repetitively poly resulted enhanced fibrosis observed lung micro computed tomography second harmonic generation microscopy optically cleared lung tissue immunohistochemistry epithelial flattening expansion epithelial mesenchymal trophic unit enhanced snail family zinc finger fibronectin expression airway epithelium also observed repetitive poly induced airway remodeling fibrosis epithelial mesenchymal transition inhibited bms administration based novel model viral inflammation induced remodeling conclude kappa major controller epithelial mesenchymal transition pulmonary fibrosis finding potentially important relevance airway remodeling produced repetitive viral infections
background link type diabetes thyroid autoimmunity well described said type diabetes results mixed far investigated prevalence determinants thyroid autoimmunity among ghanaian type diabetes patients methods case control study involving type diabetes patients non diabetic controls aged years anthropometric blood pressure measurements obtained fasting samples analyzed glucose thyroid function antibodies thyroglobulin thyroid peroxidase results prevalence thyroid autoimmunity significantly higher among tdm subjects among tdm subjects tested positive tpoab tested positive tgab tested positive autoantibodies females tdm subjects showed fold increased risk thyroid autoimmunity compared males tdm subjects hyperthyroidism increased risk thyroid autoimmunity sub clinical hyperthyroidism increased risk thyroid autoimmunity fold subclinical hypothyroidism increased risk autoimmunity fold hypothyroidism associated increased risk thyroid autoimmunity dyslipidaemia associated increased risk thyroid autoimmunity percentage increase hbac associated increased risk thyroid autoimmunity conclusion observed high prevalence thyroid autoimmunity ghanaian tdm subjects compared general population thyroid autoimmunity tdm subjects significantly associated female gender thyroid dysfunction dyslipidaemia poor glycemic control
order improve understanding effects equilibrium phase behavior structure amphiphiles emulsification process properties emulsions stabilized amphiphiles exploited known phase behavior polyoxyethylene polyoxypropylene polyoxyethylene poe pop poe amphiphilic block copolymers pluronics presence two immiscible solvents specifically considered ternary systems consisting pluronic water xylene exhibit rich phase behavior including variety water continuous oil continuous lyotropic liquid crystalline llc phases prepared emulsions final compositions different emulsification paths evaluated emulsions basis homogeneity droplet size found finer homogenous emulsions result lamellar gel structures revealed small angle ray scattering formed emulsification process emulsification path traversed lamellar llc phase attributed favorable properties lamellar structure high oil solubilization capacity concurrent facile dispersibility water relatively low interfacial tension relatively low viscosity findings reported relevant preparation emulsions diverse applications skin care products pharmaceuticals food products coatings inks agrochemicals oil dispersants nanomaterials synthesis elsevier inc rights reserved
objectives objective study report dose response odyssey phase clinical trials proprotein convertase subtilisin kexin type inhibition alirocumab patients prespecified lipid goals received per protocol dose increase every weeks methods patients receiving statins enrolled six phase randomized double blind double dummy trials weeks alirocumab versus placebo ezetimibe day subcutaneous dose increased week week ldl cholesterol ldl greater equal options studies patients without previous coronary heart disease risk factors ldl percentage reductions baseline treatment data compared week versus week results patients dose plus background statin achieved ldl less less week patients alirocumab dose increased week patients achieved ldl goals week additional reduction ldl week week adverse event rates comparable patients versus without dose increase placebo controlled trials ezetimibe controlled trials conclusion patients achieved ldl goals alirocumab plus statins receiving dose increase achieved ldl goals week additional reduction ldl copyright author published wolters kluwer health inc
background many patients complex regional pain syndrome crps report foreignness affected limb referred neglectlike symptoms nls despite similarities nls reports symptoms body image disturbances mental disorders study conducted examine associations methods investigated patients crps pain control patients chronic limb pain migraine headache nls anxiety depression depersonalization somatization assessed using validated questionnaires results seventy two percent crps patients reported least one nls two patient control groups limb pain controls nls correlated pain intensity crps patients nls correlated anxiety rho somatization rho depersonalization rho pain catastrophizing rho intensity pain duration pain pain disability conclusions crps patients nls could result somatization depression anxiety depersonalization probably pain whether associations causative must clarified longitudinal psychological studies
purpose purpose study examine rns attitudes toward pressure injury prevention strategies barriers facilitators perceived rns potentially impact adoption implementation prevention interventions intensive care unit icu examined design descriptive cross sectional survey subjects setting target population rns practicing intensive care unit icu major tertiary hospital king abdul aziz mecca saudi arabia fifty six available icu rns participated study methods data collected via survey using attitude towards pressure injury prevention instrument included items rated point likert scale modified barriers facilitators tool included items survey organized parts demographic information potential barriers optimal skin care potential facilitators skin care survey took minutes complete data analyzed descriptive correlation statistics multiple regression analysis thematic analysis undertaken qualitative data results participants demonstrated positive attitudes toward prevention significant differences found demographic characteristics participants rns attitude subscale perceived barriers facilitators associated implementing prevention critical care setting several barriers influenced ability rns implement prevention strategies including time demands beta limitation rns knowledge beta current documentation format beta statistically significant facilitating factors increased respondents ability undertake prevention ease obtaining pressure reduction surfaces beta collaboration interdisciplinary teams beta availability appropriate skin care products beta thematic analysis open ended questions highlighted workload barrier impedes implementation care specific prevention conclusion findings study highlighted icu rns positive attitude toward prevention study also identified perceived factors influencing prevention icu facilitators barriers perceived facilitators included availability pressure relieving support surfaces appropriate skin care products collaboration healthcare professional team however perceived barriers included limited prevention knowledge nurse workflow time demands documentation format findings study provide important information identifying context specific factors may influence adoption implementation prevention interventions icu
background prevalence maternal oral contraceptive pills ocp use childhood asthma high western countries aim study examine association ocp use childhood wheeze allergic diseases japan methods relevant data extracted hospital based birth cohort study named tokyo children health illness development study child questionnaire conducted pregnancy included maternal history duration ocp use identify wheeze allergic diseases children questionnaire international study asthma allergies childhood isaac used logistic regression models applied estimate association adjustments made maternal history allergy maternal education level maternal age pregnancy maternal bmi maternal smoking pregnancy mode delivery gestational age delivery daycare attendance number previous live births gender child results ocp use associated ever wheeze adjusted odds ratio aor confidence interval current wheeze aor ever asthma aor ever rhinitis aor compared prior ocp use using ocp three months statistically increased odds ever wheeze current wheeze ever rhinitis conclusions findings suggest maternal ocp use role development wheeze asthma rhinitis children extended use ocp likely increase risk wheeze rhinitis copyright japanese society allergology
chronic sports injuries knee joint common mainly caused repetitive micro trauma exertion chronic insertion tendinopathies avulsion fractures symptoms related entrapment friction impingement pathophysiologically distinguished athletes review depict characteristic
paper addresses relevant issues concerning thermal hydraulics radiation damage neutron generation target built european spallation source recently approved critical design review target unit consists set tungsten blocks placed inside wheel diameter rotates order distribute heat generated incoming protons reach target radial direction spallation material elements composed array tungsten pieces rest rotating steel support cassette distributed cross flow configuration thermal mechanical radiation effects resulting impact gev proton pulse analysed detail well evaluation inventory spallation products current design found conform specifications found robust enough deal several accident scenarios
study systematically examines collegiate leadership centers role leader development findings extend research multi institutional study leadership focusing centers unit analysis mixed method approach involved coding center websites analyzing center director responses online survey results indicate proliferation leadership centers especially public universities well leader centric philosophy directs much leader development programs results leadership centers united states highlight disconnect research practice opportunity advance leader development greater use evidence based methods
foreign investors invest authoritarian regimes despite higher political risks paper evaluate relationship foreign direct investment fdi coups political risk develop formal model leadership dynamics authoritarian regimes examine initial investment decision foreign investors affected expected likelihood coups using formal model discriminate diverging predictions made greed patronage models authoritarian regime dynamics accounting greed patronage mechanisms demonstrate patronage effects predominate increasing fdi reduces risk coup investors likely send larger fdi amounts authoritarian states coup risk high increase likelihood peaceful patronage equilibrium using large test find fdi reduces likelihood coups higher coup risk associated increased fdi less mobile sectors
article sub equation method presented finding exact solutions nonlinear fractional partial differential equations fractional complex transformation method used convert fractional order partial differential equation ordinary differential equation fractional derivatives described jumarie modified riemann liouville sense apply method nonlinear time fractional differential equations aid symbolic computation variety exact solutions obtained copyright john wiley sons ltd
rainwater tanks often provide reliable affordable water supply source rural remote areas piped water supply systems unfeasible due economic considerations however recent decades increase adoption rainwater harvesting part water supply source mix modern cities uptake rainwater harvesting influenced rise ecological sustainable development mainstream practice rainwater harvesting implemented part integrated urban water management approach alleviate pressure traditional water supply sources due increased demand driven rapid growth urbanised populations examples rainwater harvesting human settlements found since ancient times still gaps understanding role play modern cities paper reviews current international experiences rainwater harvesting particularly examining drivers adoption different urban contexts impediments faced greater mainstream adoption paper reviews current state research associated understanding value rainwater harvesting modern cities include impacts reducing mains water demand public health risks energy implications environmental impacts cost effectiveness
several studies conducted long time identify borderline personality elucidate distinctive characteristics psychopathologies however different findings obtained studies carried provided findings disorder yet understood sufficiently therefore studies prevalence comorbidity causative factors treatment approaches borderline personality disorder vital importance moreover studies suicidality among bpd patients also separate importance repetitive suicidal behaviors complicate medical care significantly review aimed reevaluate recent studies conducted diagnosis prevalence comorbidity causative factors treatment borderline personality disorder
well established approach developing new imaging agents treatments cancer begins recognition receptors overexpressed cancer cells ideally receptors would also absent minimally expressed healthy tissue delta delta opioid receptors mor dor respectively match criteria expression cancer cells higher primary lung epithelial cells naltrexone drug approved food drug administration fda treatment alcohol dependence prevention relapse opioid addiction since naltrexone binds high affinity mor dor selected platform development novel ligands capable delivering cytotoxic payload non small cell lung cancer nsclc study outlines synthesis two ligands peptide peg linkers synthesized amino naltrexone conjugated rhodamine dye vitro imaging binding affinity vivo imaging biodistribution studies transfected hek cells used model system expression opioid receptor mor delta opioid receptor dor naltrexone naltrindole used competition mor dor respectively binding affinity studies mice bearing xenograft hei cells transfected hek delta hek delta opioid receptors animal model used pet imaging vivo biodistribution studies although binding affinity studies encouraging biodistribution data selected conjugates lacked sufficient specificity conjugates abandoned development information synthesis may valuable laboratories working field published elsevier ltd
objective evaluate influence severity prematurity based birth weight maternal distress sensitivity infant development methods sixty eight mothers preterm babies babies classified extremely low birth weight elbw low birth weight vlbw assessed months infant corrected age using griffiths scales infant development care index maternal sensitivity minute mother infant interaction parenting stress index short form psi maternal distress sixty six healthy full term infants mothers assessed procedure results elbw vlbw groups showed similar levels care index psi nevertheless considering infant development outcome significant interaction birth weight maternal distress emerged higher hearing language mean quotients association non distressed mothers vlbw infants compared ones also interaction birth weight maternal sensitivity influenced infant development higher quotients eye hand coordination hearing language locomotor significantly associated sensitive mothers elbw infants conclusion severity prematurity interaction degree maternal distress sensitivity influenced level infant development practical implications taken together results suggest relevance considering severity prematurity maternal variables order implement appropriate interventions supporting parenting role pre term birth promoting adequate infant development elsevier ireland ltd rights reserved
accessible summary dialectical behaviour therapy talking therapy developed marsha linehan helps people living community also living hospitals people may problems managing emotions recent years dialectical behaviour therapy used help people learning disabilities cope feelings anxiety trauma related disorders mood disorders many research papers showing used forensic learning disability services research tells story seven women learning disabilities took part dialectical behaviour therapy whilst living forensic service story experiences important research literature help services think needed introduce new type therapy dialectical behaviour therapy abstract background research aimed capture experiences women learning disabilities living secure services undertook dialectical behaviour therapy dbt first people trust hoped experiences may guide inform services undertaking process materials methods interpretative phenomenological analysis ipa used provide flexible framework make sense way women interpreted experiences results discussion analysis identified three main themes dbt think dbt using dbt qualitative approach adds valuable contribution wider literature highlighting importance capturing women voices conclusion published literature regarding effectiveness dbt written first hand service user experiences hoped research offers unique insight women experience
myeloid plasma cell lymphoblastic neoplasms expected findings bone marrow much less commonly diagnosed primary processes lymph nodes objective review aid pathologists recognizing common hematopoietic neoplasms unusual setting initial presentation lymph nodes review historical background evolution testing strategies presented improve understanding need accurate diagnosis classification using current nomenclature review based peer reviewed literature personal experience authors university minnesota medical center fairview provides lymph node diagnostic consultation services busy oncology therapeutic hematopoietic cell transplant divisions serving patients around globe although readily recognizable present bone marrow myeloid leukemia form myeloid sarcoma plasmacytoma lymphoblastic lymphoma create diagnostic classification challenges present primary lymph node pathologies use diagnostic tools may necessary ensure accurate reproducible diagnoses elsevier inc rights reserved
cultural practices socialize people relate others different ways one critical way interpersonal bonds formed maintained via empathy emotional reactivity toward others experiences however extent individuals different cultures vary dispositional empathy correlates differences relatively unknown thus current study explored cultural variation empathy variation related psychological characteristics prosocial behavior across cultures evidence original sample adults across countries reveals higher empathy countries also higher levels collectivism agreeableness conscientiousness self esteem emotionality subjective well prosocial behavior findings reveal empathy situated within broader nomological network psychological characteristics emotional expression experiences prosocial behavior across cultures current study expands understanding psychological characteristics vary across cultures characteristics manifest broader national indicators prosocial behavior
growing link history cannabis use neurocognitive performance patients schizophrenia fewer neurocognitive deficits may marker superior social cognition needed obtain illicit substances cannabis use may indicate distinct path schizophrenia less neurocognitive vulnerability study sought determine whether relationship cannabis use executive function exists independently social cognition eighty seven patients schizophrenia administered measures social cognition executive function social cognition assessed using bell lysaker emotion recognition test measure affect recognition eyes hinting tests measure theory mind executive function assessed mental flexibility component delis kaplan executive functioning scale relations variables examined structural equation modeling cannabis use positively related executive function negatively related affect recognition relationship theory mind indirect effects illicit substances amount regular cannabis use alcohol use related worse affect recognition relationship cannabis use better executive function supported explained superior social cognition
rainwater harvesting techniques used worldwide augment potable water supply provide water small scale irrigation practices increase rainwater use efficiency sustained crop growth arid semi arid regions decrease urban stormwater flow volumes general relieve dependency urban water resources cycles number methods established recent years estimate reliability rainwater catchment systems rwcs thereby properly size components roof catchment area storage tank size system given climatic region methods typically use historical stochastically generated rainfall patterns quantify system performance optimally size system latter accounting possible rainfall scenarios based statistical relationships historical rainfall patterns design rwcs systems sustainably meet water demand future climate conditions paper introduces method employs climatic data general circulation models gcms develop suite catchment area storage size design curves capture uncertainty future climate scenarios monthly rainfall data time period statistically downscaled daily values using markov chain algorithm results used gcms yield rainfall patterns statistically consistent historical rainfall patterns process demonstrated application two climatic regions federated states micronesia fsm western pacific wherein majority population relies rainwater harvesting potable water supply use design curves communities provide household rwcs achieve certain degree storage reliability method described herein applied generally geographic region used first assess future performance existing household systems second design modify systems yield adequate storage future climate conditions elsevier rights reserved
raw signal simulation useful tool synthetic aperture radar sar system design mission planning processing algorithm testing inversion algorithm design time frequency synchronization key technique bistatic sar bisar system raw data simulation effective tool verifying time frequency synchronization techniques according two dimensional frequency spectrum fixed receiver bisar rapid raw data simulation approach time frequency synchronization errors proposed paper inverse stolt transform frequency domain phase compensation range doppler frequency domain method significantly improve efficiency scene raw data simulation simulation results point targets extended scene presented validate feasibility efficiency proposed simulation approach
plant based techniques measure crop water status offer advantages soil based methods objective study quantify relationship leaf thickness measurements promising plant based technique leaf relative water content rwc assess model across different species leaf positions relationship rwc relative thickness determined corn zea mays sorghum sorghum bicolor moench soybean glycine max men fava bean viciafaba rwc calculated measured leaf water content leaf water content full turgor measured leaf thickness leaf thickness full turgor two leaves top middle bottom five plants species collected days age leaf samples brought full turgor left dehydrate lab leaf thickness measured using magnetic field sensor water content using weight loss rwc relationship showed distinct breakpoint hypothesise coincides turgor loss point linear piecewise modelling used regress rwc versus resulted models explaining variations precision improved including leaf position plant model piecewise model parameters related salt tolerance species also indicator drought resistance generally species greater drought salinity tolerance larger breakpoint iagre published elsevier ltd rights reserved
cases fungal infection remained undiagnosed especially pathogens uncommon require specific conditions vitro growth several microbial species present specimen ultra deep sequencing uds could considered precise tool identification involved pathogens order upgrade patient treatment study report implementation uds technology medical laboratory follow atypical fungal infection case thanks uds technology document first case gastro intestinal basidiobolomycosis gib due basidiobolus meristosporus diagnosis suspected histopathological examination conventional microbiological methods failed supply proof final diagnosis made means original approach based uds dna extracted embedded colon biopsy obtained hemicolectomy fragment encompassing internal transcribed spacer rdna region pcr amplified amplicon library prepared using genome sequencer junior titanium kits roche life sciences library pyrosequenced junior roche life sciences using method sequences bases generated used uds analysis meristosporus represented sequences average homology phylogenetic tree basidiobolus reference sequences confirmed presence meristosporus bootstrap value
aim study assess environmental impact microbial fuel cells mfcs implerriented constructed wetlands cws aim life cycle assessment lca carried comparing three scenarios conventional system without mfc implementation system coupled gravel based anode mfc system coupled graphite based anode mfc systems served population equivalent designed meet effluent quality since mfcs implemented cws improve treatment efficiency cws coupled mfcs lower specific area requirement compared conventional system functional unit wastewater lca performed software simapro using cml baseline method three scenarios considered showed similar environmental performance categories considered exception abiotic depletion potential impact category potential environmental impact system coupled gravel based anode mfc around times higher generated conventional system system coupled graphite based anode mfc attributed large amount less environmentally friendly materials metals graphite mfcs implementation especially case gravel based anode mfcs therefore system coupled graphite based anode mfc appeared environmentally friendly solution replace conventional cws reducing system footprint economic assessment showed system around times expensive conventional system elsevier rights reserved
russian cards problem alice bob cath draw cards respectively publicly known deck alice bob must communicate cards without cath learning holds single card solutions literature provide weak security alice bob exchanges allow cath know certainty holds card perfect security cath learns probabilistic information holds given card propose intermediate notion call strong security probabilities perceived cath may change factor show strategies based affine projective geometries yield strong safety arbitrarily small appropriately chosen values
despite several conventional potent antibacterial therapies bacterial infections pose significant threat human health emerging leading cause death worldwide due development antibiotic resistance bacteria pressing demand discover novel approaches developing effective therapies treat multidrug resistant bacterial strains biofilm associated infections therefore attention especially devoted new emerging branch science nanotechnology design non conventional antimicrobial chemotherapies range nanomaterials nano sized carriers conventional antimicrobial agents fully justified potential combat bacterial diseases reducing cell viability attenuating quorum sensing inhibiting eradicating biofilms communication summarizes emerging nano antimicrobial therapies treating bacterial infections particularly using antibacterial quorum quenching anti biofilm nanomaterials new approaches tackle current challenges combating infectious diseases
second two part study discusses multimode combustion mild hybrid electric vehicle homogeneous charge compression ignition hcci combustion oxidizes oxygen storage capacity osc three way catalyst twc thereby removing twc ability convert nox lean conditions despite prolonged operation hcci mode enabled electric motor depletion osc causes significant penalties fuel economy amounts tailpipe nox substantial counter intuitively seen decreasing sizes hcci regime osc results reduced tailpipe nox maintaining fuel economy benefits
paper proposes design asic weather monitoring application implement using fpaa field programmable analog array fpga field programmable gate array three atmospheric parameters temperature humidity considered experimentation sensor signals ported fpaa input ports analog signal processing serial digital output data fpaa fed custom designed digital processor fpga real time atmospheric parameters displayed lcd display simulation results obtained custom designed processor using xilinx spartan tool design optimized better performance hardware implementation proposed asic mixed signal processer uses anadigm ane analog processing xilinx spartan fpga digital processing experiment result shows good circuit integrity functionality also faster computational response
background medication prior authorization commonly occurring requirement particularly medications used rare conditions based standard definitions cancer many blood disorders affecting children rare study aims describe relative frequency requests association payers medications order identify opportunities improve system efficiency procedure requests medication logged prospectively patients seen single institution month period period prevalence used estimate relative frequency requests descriptive statistics summarized relationship among payers medications approvals relative frequency requests results study duration clinic days patient visits total medication requests received resulting period prevalence rate patient visits medication requests available outcome data ultimately approved additional provider efforts median clinic staff time spent per request min interquartile range min striking process heterogeneity among different payers conclusion virtually medication request pediatric hematology oncology pho leads alterations care medication utilization management strategies pho fail provide benefits reported areas medicine unmeasured negative effects timeliness care parenteral psychological emotional health opportunity increasing efficiency payer provider collaboration creation prescribing standards pho patients
objectiveto determine whether baseline nausea prior triptan treatment migraine impact effectiveness diclofenac potassium oral solution treating acute migraine backgrounda great deal variability exists patients response migraine medications migraine associated nausea common debilitating reduce effectiveness oral medications may cause patients delay taking oral medications known diminish therapeutic outcomes avoid taking altogether gastroparesis may associated nausea also inhibits drug absorption resulting lower bioavailability studies shown nausea time drug administration predicts poorer response triptan treatment interest understand effective migraine medications patients poor response triptans methodsdata two randomized double blind placebo controlled trials pooled post hoc subgroup analyses performed patients without nausea baseline patients without prior triptan treatment efficacy assessments included percentage patients hours postdosing headache pain free hpf primary endpoint without photophobia without phonophobia without nausea without severe degree disability cochran mantel haenszel test stratified analysis center used evaluate treatment effect effects nausea prior triptan use determined using logistic regression factors treatment group analysis center nausea prior triptan use time dosing interaction treatment group nausea prior triptan use time dosing resultsthe modified intent treat population consisted patients active drug placebo majority patients female time dosing patients reported nausea treated attack prior triptan use recorded headache pain nausea photophobia phonophobia patients active treatment group statistically significantly better response receiving placebo regardless whether nausea baseline logistic regression analysis treatment group predicted response parameters detectable group interaction baseline nausea well treatment group predicted whether patients recorded severe disability hours patients active treatment group significantly likely headache pain free hours dosing whether previously treated triptan triptan naive patients triptan experienced patients headache pain free interestingly placebo groups triptan naive patients also likely logistic regression analysis treatment group predicted headache pain response triptan use predicted lack response interaction two prior triptan use predict outcome measures conclusionsnausea time dosing diminish effectiveness diclofenac potassium oral solution rapid absorption profile may enhance effectiveness patients nausea prior triptan use predicted poorer headache response hours postdose suggesting possibility subset patients likely refractory triptans diclofenac diclofenac potassium oral solution effective triptan naive patients reliable inference made study order treatment
objectives compare use medical services provided minnesota senior health options msho special program designed serve dually eligible older persons provided controls received fee service medicare medicaid managed care design quasi experimental design using two control groups separate matched cohort rolling cross sectional analyses regression models used adjust case mix differences setting urban minnesota community nursing home long term care participants dually eligible elderly msho enrollees community nursing homes compared two sets controls one drawn nonenrollees living area control another comparable persons living another urban area program available control cohorts living community nursing homes included measurements use hospitals emergency rooms physician visits results community cohort significant differences hospital admission rates hospital days msho enrollees significantly fewer preventable hospital admissions significantly fewer preventable emergency services control group msho nursing home enrollees significantly fewer hospital admissions either control group without adjustment months msho enrollees significantly fewer hospital days preventable hospitalizations control group msho enrollees significantly fewer emergency room visits preventable emergency room visits either control group conclusion general results evaluation mixed favor msho effect msho stronger nursing home enrollees community enrollees lower rate preventable hospitalizations emergency room visits msho enrollees suggests msho affected process care providing types preventive community care services community residents
background growing acceptance increase thyroid cancer incidence part result overdiagnosis small low risk papillary microcarcinomas pmcs indolent clinical course although surgery cornerstone treatment patients pmcs recent management guidelines shifting toward inclusion conservative treatments active surveillance little evidence clinicians experience managing pmc patients attitudes toward treatment options including willingness accept nonsurgical option aim study understand clinicians perceive diagnosis pmc potential changes terminology treatment options available patients methods qualitative study using semi structured interviews conducted november may clinicians seven endocrinologists thyroid surgeons transcribed audio recordings thematically coded framework method used analyze data results across sample clinicians manage thyroid cancer patients awareness overdiagnosis overtreatment pmc common however little acceptance active surveillance manage patients clinicians feel comfortable recommending management approach worried risk metastases feel evidence support approach strong enough also believed patients currently high preference surgery majority clinicians believe changing terminology diagnosis viable strategy reduce patients anxiety perceived preference aggressive treatments however clinicians felt thyroid nodules biopsied could help minimize risk overdiagnosis pmc conclusions study based non representative sample clinicians remains important limitation provides revealing insight clinicians management preferences decision making small low risk thyroid cancers time management guidelines practices evolving suggests clinicians may ready accept nonsurgical options changes terminology evidence support options changes stronger
magnetic resonance imaging mri usage anecdotally increased due principles alara desire image gently aside single abstract emergency medicine literature pediatric emergency department mri usage described objective determine whether mri use indeed increasing high volume urban pediatric emergency department mri availability also sought determine exams time periods demographics influenced trend institutional review board exemption obtained emergency department patient visit exam data obtained hospital database time period mri usage data normalized using emergency department patient visit data determine usage rates test used compare mri use gender chi square test used test trends mri usage study period patient age mri usage hour weekday tabulated determine peak trough usage times mri usage rate per emergency department patient visit headache pain rule appendicitis common indications neuroradiology musculoskeletal trunk exams respectively usage female patients significantly greater males respectively usage significantly increased year period use significantly increased age respectively sixty percent exams performed hours highest volume hour lowest mri use highest thursdays lowest sundays mri patients respectively mri use children increased study period notably females weekdays hours
paper discuss four types electrical network circuits used modeling amino acid sequences gross molecular level standard amino acids partitioned mutually exclusive partitions based chemical structural properties partition assigned distinct electrical circuit enables construction electrical networks representing amino acid sequence networks analyzed establish putative relationships network electrical response known behavior protein sequences aid analysis circuit response also developed unique visualization technique similar circuits used model dna rna sequences well non biological strings applications message encryption computer security
paper active controller nonlinear hysteretic structure time delay studied nonlinear hysteretic behavior system illustrated bouc wen model genetic algorithm used identify optimal parameters bouc wen model order describe hysteresis phenomenon experimental system specific transformation augmentation state parameters motion equation system explicit time delay transformed standard state space representation without explicit time delay fourth order runge kutta method instantaneous optimal control method applied controller design time delay finally numerical simulation experimental results flexible beam using proposed time delay controller carried results indicate control performance deteriorate time delay taken account controller design time delay controller proposed paper effectively compensate time delay get better control effectiveness also work well small large time delay problems
paper analyses reliability metrics surges affecting insulation cable submersible electric motor system electric submersible pump equipment paper contains assessment methods reliability metrics based statistical laws superposition mean time failures mtbf cable submersible electric motor system elements estimation insulation resource consumption submersible electric motor surges submersible electric motor sem resource consumption calculation included calculation results presented form electric motor survival probability dynamic pattern function resource consumption actions protect submersible electric motors surges offered
therapeutic effect glial progenitor transplantation diseases dysmyelination currently attributed formation new myelin using magnetic resonance imaging mri show therapeutic outcome dysmyelinated shiverer mice dependent extent cell migration presence mature compact myelin human mouse glial restricted progenitors grps transplanted rag shiverer mouse neonates followed one year mouse grps produced mature myelin detected multi parametric mri showed limited migration without extended animal lifespan sharp contrast human grps migrated extensively significantly increased animal survival production mature myelin occur weeks post grafting conclude human grps extend survival transplanted shiverer mice prior production mature myelin mouse grps fail extend animal survival despite early presence mature myelin paradox suggests transplanted grps provide therapeutic benefits biological processes formation mature myelin capable foster rapid nerve conduction challenging current dogma primary role myelination regaining function central nervous system elsevier inc rights reserved
essay explains collection papers volume contributes growing scholarly literature dealing hockey role canadian society culture particular project explores aspects hockey connection sports media sufficiently examined historians cultural history hockey late nineteenth early twentieth centuries researched thoroughly working fields sport history canadian history cultural studies study addresses deficiency assessing key elements media constructed world hockey early years stanley cup competition examines local national newspaper coverage championship hockey games order understand interurban regional rivalries national scope sports media violence gender construction community representation local national audiences exposed similar media texts narratives hockey developed shared understandings cultural meanings sport throughout canada
due high vulnerability sram based fpgas single event upsets seus effective fault tolerant soft processor architectures must considered use fpgas build embedded systems critical applications past detection symptoms soft errors behavior microprocessors used implementation low budget error detection techniques instead costly hardware redundancy techniques enable development low cost error detection techniques fpga soft processors propose depth analysis symptoms seus fpga configuration memory end present flexible fault injection platform based open source cad framework rapid smith soft error sensitivity analysis soft processors xilinx sram based fpgas platform supports estimation soft error sensitivity per configuration bit frame processor component benchmark fault injection performed chip dedicated microcontroller also monitors processor behavior identify specific symptoms consequences soft errors performed analysis showed symptoms used build efficient low cost error detection scheme proposed platform demonstrated extensive fault injection campaign leon soft processor
installation offshore scour protection systems offshore wind farms allows avoid effect scour phenomenon around structures date numerous research projects carried justify necessity scour protection systems also optimize design protection systems based riprap frequently used due low cost easy availability compared solutions geotextile bags prefabricated concrete blocks sizing structures performed according series recommendations optimize costs associated studies real data allowed identify need protections investigation aims assess functionality scour protections adopted available data characteristics scour depth developed around foundations sense paper presents results study analyzes functionality scour protections different european offshore wind farms
rationale gastrointestinal mucormycosis gim kind opportunistic fungal infection poor prognosis usually occurs patients immune deficiency reported case immunocompetent male patient patient concerns patient presented abdominal distension gastrointestinal bleeding diagnoses variety hemostatic methods ineffective stop bleeding patient finally received laparotomy jejunum lesions found interventions pathological examination confirmed gastrointestinal mucormycosis jejunum outcomes however systemic anti fungi therapy patient died septic shock lessons diagnosis mainly relies pathological examination early diagnosis early application systemic amphotericin liposome fundamental improving prognosis
objectives abscesses chronic wounds common among injection drug users idus though chronic wounds understudied assessed risk factors associated acute chronic wounds within community based population idus frequenting baltimore city needle exchange program bnep methods performed cross sectional study bnep clients aged years completed person survey regarding active prior wounds including abscesses duration weeks injection practices skin care factors associated wounds analyzed using univariate multivariate logistic regressions results participants men white african american type current wound active abscess current chronic wound abscesses common women odds ratio confidence interval reporting skin popping multivariate model risk factors abscess included injecting family member partner adjusted aor multivariable analysis current chronic wounds cleaning skin alcohol injection protective aor conclusions abscesses chronic wounds prevalent among sample idus baltimore abscesses associated injection practices chronic wounds seemed linked varying skin tool cleaning practices pressing need wound related education treatment efforts among idus greatest risk skin related morbidity
energy efficiency always priority designing wireless sensor networks introduction mobile agent technology wireless sensor networks collaborative signal information processing provided new scope efficient processing aggregation data mobile agent based distributed computing paradigm offers numerous benefits existing commonly used client server computing paradigm wireless sensor networks mobile agent performs task data processing data aggregation node level rather sink thus eliminating redundant network overhead one important issues mobile agent based paradigm planning itinerary agent traversal paper proposed dynamic mobile agent based data aggregation approach takes consideration energy efficiency network lifetime end end delay aggregation ration making decision migration agent multihop sensor network approach focuses finding informative route traversing comparatively less number nodes consequently mobile agent takes less time return processing element thus exhibiting lower delay
measure nonlinear impedance interdigital electrode solution system novel method based free damped oscillation proposed high valued active inductance adjustable negative resistance constructed operational amplifier second order oscillation system measurement set connecting active inductance device test active inductance designed around meet measurement requirements low frequency negative resistor utilized adjust damping coefficient oscillation system order obtain enough number ring oscillation cycles parameter estimation free damped oscillation signal oscillation system obtained square wave voltage excitation processed hilbert transform instantaneous capacitance resistance calculated simultaneously implement nonlinear impedance measurement operational availability proposed method verified experimental results commercial available resistors capacitors impedance nonlinearity gold interdigital electrode immersed kcl solutions different concentration tested compared obtained sweep amplitude sinusoidal excitation methods results indicate proposed method successfully obtain impedance nonlinearity half square wave period
construction three gorges dam china subsequent impoundment yangtze river induced major land use change three gorges reservoir region fosters increased inputs sediment nutrients diffuse sources water bodies several government programs implemented mitigate high sediment nutrient loads reservoir however institutional weaknesses focus economic development far widely counteracted effectiveness programs study eco hydrological model soil water assessment tool used assess effects changes fertilizer amounts conditions bench terraces xiangxi catchment three gorges reservoir region diffuse matter releases study aims identifying efficient management measures priority results show reduction fertilizer amounts reduce phosphorus loads considerably without inhibiting crop productivity condition terraces catchment strong impact soil erosion phosphorus releases agricultural areas hence economically feasible programmes focusing construction maintenance terraces region implemented additionally intercropping corn fields well efficient fertilization schemes agricultural land identified potential instruments reduce diffuse matter loads study carried three gorges region findings may also beneficial reduction water pollution mountainous areas strong agricultural use
paper proposes framework development sensor node software various operating systems sensor network environment proposed development framework consists attributes code templates development support tool sensor node software developed based framework four steps sensor network modeling pim design psm design code generation accordingly paper presents methods attributes design code templates design pim psm mapping source code generation proposed technique reusability sensor network software increased since models attributes code templates reused various operating systems framework productivity software development increased software design easily performed using attributes software codes nodes sensor network generated model also expandability sensor network software increased since new functions existing operating systems new operating systems added framework sensor network software rebuilt applying added functions operating systems
non verbal communication involves encoding transmission decoding non lexical cues realized using vocal prosody visual gaze body language channels conversation cues perform function maintaining conversational flow expressing emotions marking personality interpersonal attitude particular non verbal cues speech paralanguage non verbal vocal events laughters sighs cries used nuance meaning convey emotions mood attitude instance laughters associated affective expressions fillers urn urn used hold floor conversation paper present automatic non verbal vocal events detection system focusing detect laughter fillers extend system presented interspeech social signals sub challenge winning entry challenge frame wise event detection test several schemes incorporating local context detection specifically incorporate context two separate levels system raw frame wise features output decisions furthermore system processes output probabilities based heuristic rules order reduce erroneous frame based predictions overall system achieves area receiver operating characteristics curve detecting laughters fillers test set drawn data specifications interspeech social signals sub challenge perform analysis understand interrelation features obtained results specifically conduct feature sensitivity analysis correlate feature stand alone performance observations suggest trained system sensitive feature carrying higher discriminability implications towards better system design elsevier ltd rights reserved
background solifenacin effective well tolerated treatment adult overactive bladder oab symptoms evaluated placebo controlled paediatric clinical trials objectives evaluate efficacy safety daily oral solifenacin suspension oab patients aged children optimum dose end treatment eot outcome measurements statistics superiority solifenacin versus placebo change frombaseline eot mean volume voided micturition mvv primary endpoint daytime maximumvolume voided micturition dmaxvv incontinence episodes mean mean number incontinence free days nights micturition frequency micturition frequency adjusted baseline total voided volume vtb exploratory parameter efficacy parameters analysed using analysis covariance safety parameters treatment emergent adverse events serious adverse events laboratory variables vital signs electrocardiogram postvoid residual volume summarised using descriptive statistics results limitations children solifenacin superior placebo terms change baseline eot mvv solifenacin placebo difference confidence interval dmaxvv difference adjusted mean change baseline solifenacin placebo vtb adjusted micturition frequency endpoints significantly different solifenacin well tolerated adolescents possible draw firm efficacy conclusions low numbers recruited conclusions daily solifenacin oral suspension children oab superior placebo mvv primary efficacy endpoint well tolerated patient summary study daily oral suspension solifenacin children aged overactive bladder superior placebo increasing mean volume voided micturition primary efficacy variable study solifenacin well tolerated low incidence dry mouth constipation study registered clinicaltrials gov nct european association urology published elsevier rights reserved
introduction polyglandular autoimmune syndrome pas type rare condition defined coexistence autoimmune thyroid disorder endocrine autoimmune diseases including type diabetes without adrenal dysfunction pas may associate non endocrine autoimmune diseases overlapping multiple autoimmune syndromes mas present case pas iii mas type including autoimmune thyroiditis autoimmune diabetes vitiligo lupus erythematosus associated adult onset atopic dermatitis combination reported previously case report years old woman registered nurse working dialysis unit previously diagnosed vitiligo euthyroid autoimmune thyroiditis disseminated granuloma annulare personal familial history atopic disorders presented clinic disseminated eczematous lichenoid cutaneous rashes tested positive antinuclear anti double stranded dna anti histone antibodies inflammatory syndrome marginal lymphopenia diagnosed systemic lupus erythematosus sle subsequently moderate hyperglycemia positive anti glutamic acid decarboxylase antibodies low peptide level prompted diagnosis autoimmune diabetes recurrent flexural eczematous rashes negative epicutaneous tests positive specific ige tests common allergens fulfilled clinical criteria diagnosis atopic dermatitis clinical immunological glycemic status controlled low doses oral prednisone methotrexate week antimalarials metformin emollients photoprotection changing workplace immunosuppressive treatment could discontinued patient maintained normal immunological biochemical profile months follow case brings unique perspective evolution associations spectrum management challenges endocrine polyautoimmunity associated atopic diathesis
schizophrenia debilitating brain disorder complex genetic architecture genetic studies especially recent genome wide association studies gwas identified multiple variants loci conferring risk however efficiently extract meaningful biological information bulk genetic findings remains major challenge pressing need integrate multiple layers data various sources genetic findings gwas copy number variations cnvs association linkage studies gene expression protein protein interaction ppi expression expression quantitative trait loci eqtl encyclopedia dna elements encode data provide comprehensive resource facilitate translation genetic findings molecular diagnosis mechanism study developed szdb database http www szdb org comprehensive resource research genetic data gene expression data network based data brain eqtl data snp function annotation information systematically extracted curated deposited szdb depth analyses systematic integration performed identify top prioritized genes enriched pathways multiple types data various layers research systematically integrated deposited szdb depth data analyses integration identified top prioritized genes enriched pathways showed genes implicated highly expressed human brain proteins encoded prioritized risk genes significantly interacted user friendly szdb provides high confidence candidate variants genes functional characterization important szdb provides convenient online tools data search browse data integration customized data analyses
cholecystectomy rates biliary dyskinesia children rising united states countries biliary dyskinesia validated functional gallbladder disorder adults requiring biliary colic diagnosis contrast studies children require upper abdominal pain absent gallstones ultrasound abnormal gallbladder ejection fraction gbef cholecystokinin stimulated cholescintigraphy diagnosis aimed systematically review existing literature biliary dyskinesia children determine validity reliability diagnostic criteria gbef assess outcomes following cholecystectomy performed systematic review following prisma checklist searched databases including pubmed scopus embase ovid medline proquest web science cochrane library bibliographies articles screened additional studies search terms yielded articles included three articles manually added searched references reviewed peer reviewed publications retrospective chart reviews heterogeneity diagnostic criteria gbef values outcomes laparoscopic cholecystectomy varied success consensus concerning factors influencing outcomes observational retrospective study designs comprised review limited interpretation safety efficacy investigations treatment biliary dyskinesia children symptoms biliary dyskinesia overlapped functional dyspepsia need consensus symptoms defining biliary dyskinesia validation testing required diagnosis biliary dyskinesia randomized controlled trials comparing medical versus surgical management children upper abdominal pain
research past years demonstrated excessive alcohol use meets epidemiological criteria causality neither necessary sufficient cause excessive alcohol use contribute occurrence partner violence contribution approximately equal contributing causes gender roles anger marital functioning current theories excessive drinking results partner violence provide potentially valuable framework respect targeted interventions respect alcohol related partner violence interventions address
large number transmission voltage level plants integrated existing transmission networks penetrations weak transmission links increases impact power system stability also increases low frequency oscillations produced due reason influence low frequency oscillations vary positive negative depending upon location sizes large scale plants low frequency oscillation lfo changes location changes possible shift plants ideal location influence low frequency oscillations less damping controller designed order reduce low frequency oscillations pod based minimax linear quadratic gaussian method order illustrate damping performance designed controller test system prone power system oscillations used test system model simulated connected analyse produced oscillations mitigating oscillations damping controller designed designing minimax lqg controller state space representation entire power system model required state space matrices following step step procedure minimax lqg method controller matrix formulated pod used eliminate low frequency oscillations controller also designed using lqg method comparing damping oscillations two methods see minimax lqg method gives better damping oscillations
meet stringent environmental requirements automobile exhaust gas emissions diesel engines recently received increased attention due high heat efficiency lower fuel consumption reduce exhaust gas simultaneously fuel combustion must precisely controlled example oxygen concentration affects emissions controlled exhaust gas recirculation egr variable nozzle turbo vnt however realizing controlled design difficult due system non linearity strong interference egr vnt recently various design methods employed called model based control design design approach difficult use controlled object complex currently mass production uses gain scheduling map based proportional integral derivative pid control gain tuned various operational points however map calibration many drawbacks including time consuming tuning difficulty tuning transient operations problems adapting individual variations engine characteristics study proposes construction method model free adaptive pid controller using simultaneous perturbation stochastic approximation spsa performance confirmed engine bench test
pregnancy puerperium risk factors cerebral venous sinus thrombosis cvst however studies describing diagnosis management population limited objective study amalgamate published case reports series regarding diagnosis management cvst pregnancy puerperium searches pubmed cochrane library performed using search terms pregnancy puerperium sinus occlusion sinus thrombosis studies included pooled analysis included individual patient symptoms management approach follow condition multivariate regression utilized assess effect non modifiable factors excellent outcome mrs sixty six patients included mean duration symptom onset diagnosis days clot involvement superior sagittal sinus seen cases transverse sigmoid deep venous system cases management approaches included anticoagulation patients intra arterial thrombolysis alone thrombectomy thrombolysis fifty nine percent patients mrs follow mrs presentation headache alone associated excellent outcome multivariate analysis coma obtundation predicted excellent outcome compared thrombolysis alone patients undergoing thrombolysis thrombectomy demonstrated trend toward better outcome elsevier ltd rights reserved
paper propose novel two step building extraction method remote sensing images integrating saliency cue first utilize classical features shadow color shape find initial building candidates fully connected conditional random field model introduced step ensure buildings incorporated hard remove mislabled rooftops building candidates using classical features adopt saliency cue new feature determine whether rooftop segmentation patch obtained previous step basic idea behind use saliency information rooftops likely attract visual attention surrounding objects based specifically designed saliency estimation algorithm building object extract saliency cue local region building candidate integrated probabilistic model get final building extraction result show saliency cue provide efficient probabilistic indication presence rooftops helps reduce false positives without increasing false negatives time experimental results two benchmark datasets highlight advantages integration saliency cue demonstrate proposed method outperforms stateof art methods
background meetingdem study aims implement evaluate innovative inclusive approach supporting community dwelling people mild moderate dementia family carers called meeting centers support program mcsp three countries european union italy poland united kingdom demonstrated benefits person centered approach developed netherlands include high user satisfaction reduced behavioral mood problems delayed admission residential care lower levels caregiving related stress higher carer competence improved collaboration care welfare organizations methods project carried month period project partners three countries utilize adapt strategies tools developed netherlands phase one month activities focus establishing initiative group relevant organizations user representatives country exploring pathways care potential facilitators barriers implementing program developing country specific implementation plans materials phase two month training provided organizations staff meeting centers established evaluated impact behavior mood quality life people dementia carers cost effectiveness changes service use user satisfaction implementation process discussion overall evaluation draw together findings three countries develop recommendations successful implementation mcsp across meeting centers approach widely implemented could lead major improvements dementia care across europe beyond
paper propose optimization framework interior carving fabricated shapes interior carving important technique widely used industrial artistic designs achieve functional purposes hollowing interior shapes objects formulate functional purpose objective function optimization problem whose solution indicates optimal interior shape contrast previous volumetric methods directly represent boundary interior shape triangular mesh use eulerian semiderivative relate time derivative object function virtual velocity field iteratively evolve interior shape guided velocity field surface tracking iteration compute velocity field guaranteeing decrease objective function solving linear programming problem demonstrate general framework novel application designing objects floating fluid two previously investigated applications print various optimized objects verify effectiveness
development humoral immune response influenza vaccines occurs multisystems level due orchestration required robust immune responses multiple genes regulatory components across multiple cell types involved examined influenza vaccination cohort using multiple high throughput technologies study sought thorough understanding immune cell composition gene expression relate contribute interindividual variation response influenza vaccination first hypothesized many differentially expressed genes observed influenza vaccination result changes composition participants peripheral blood mononuclear cells pbmcs assessed using flow cytometry demonstrated genes study correlated changes pbmc composition gathered genes publically available pbmc based vaccine studies identified average correlated specific cell subset levels study permutation used control false discovery suggesting associations identified likely general features pbmc based transcriptomics second hypothesized robust models vaccine response could generated accounting interplay pbmc composition gene expression gene regulation employed machine learning generate predictive models cell elispot response outcomes hemagglutination inhibition hai antibody titers top hai cell elispot model achieved area receiver operating curve auc respectively linear model coefficients determination cell elispot outcomes cpg methylation greatest predictive ability highlighting potentially novel regulatory features important immune response cell elisot models using pbmc composition lower performance auc highlighted well known mechanisms analysis demonstrated three data sets cell composition mrna seq dna methylation may provide distinct information prediction humoral immune response outcomes believe findings important interpretation current omics based studies set stage thorough understanding interindividual immune responses influenza vaccination
exploratory online investigation sought examine links african american college women gender role attitudes black racial identity attitudes domestic violence attitudes toward african american women heterosexual marital relationships domestic violence occurs less sophisticated black racial identity attitudes pre encounter immersion emersion predicted greater self reports justifying domestic violence toward african american women believing african american women benefit abuse pre encounter immersion emersion attitudes also predicted less willingness help victims afrocentric worldview internalization afrocentricity positively predictive believing african american women benefit domestic violence well greater willingness help victims appreciating one african american identity racial ethnic groups internalization multiculturalist inclusive predicted less justification fewer reports african american women benefit abuse greater willingness help victims post hoc mediation analyses revealed gender role attitudes investment protecting african american male domestic violence perpetrators black male victimage justification beliefs mediated link internalization afrocentricity attitudes belief african american women benefit abuse
first time occurrence chytrid batrachochytrium dendrobatidis fungus infection fresh water prawn macrobrachium rosenbergii grow farms reported extensive survey carried farms indicates dendrobatidis responsible major pandemics rosenbergii culture ponds evidenced unique characteristics presence fungal hyphae claws features infected prawn pathogenicity fungus histopathology hematology immunological response infected prawn reported clinical symptoms include dull body color abnormal protrusion associated grayish white color wooly appearance radiating grayish white fungal filaments claw histopathology studies revealed infection resulted faded eye color occurrence dark spots melanization cephalothorax muscles translucent musculature cuticular erosion tissue atrophy proliferated infiltrated cells causing distension gross enlargement gill lamellae optimum dose zoospores prawn resulted mortality days high dose zoospores prawn infection caused total mortality days week total hemocyte counts thcs significantly decreased phenoloxidase level relative superoxide anion production level superoxide dismutase sod activity registered significant increase compared control cumulative mortality challenged days prevalence infection high cooler winter season october november december low hot summer season march april may june indicating seasonal influence wielding significant effect mortality hematology immunology profiles statement relevance india shrimp prawn ponds affected disease resulting annual loss million million million million ayyappan intensive prawn farming favors rapid deterioration environmental conditions increase incidence diseases failure culture therefore augmenting immune resistance anti environmental stress prawns primary concern chytridiomycosis infectious disease caused chytrid batrachochytrium dendrobatidis non hyphal zoospore fungus belonging chytridiomycota canter lund lund blastocladiomycota james phylum chytrids diverse group microscopic fungi barr barr kendrick disperse aqueous environment motile zoospores single posterior whiplash flagellum sparrow chytrids well documented amphibians longcore berger number fungal pathogens isolated identified prawns shrimps krishnika ramasamy karthikeyan gopalakrishnan hatai cruz silva ramaiah recently fungal pathogen like aspergillus awamori isolated marine shrimp liptopenaeus vannamei karthikeyan gilbertella persicaria penaeus monodon knowledge report batrachochytrium dendrobatidis infection fish prawn shrimp elsevier rights reserved
hybrid power system uses many wind turbine generators wtg solar photovoltaics isolated small areas however output power renewable sources constant diverge quickly serious effect system frequency continuity demand supply order solve problem paper presents new frequency control scheme hybrid power system ensure supplying high quality power isolated areas proposed power system consists wtg aqua electrolyzer fuel cell battery energy storage system bess flywheel diesel engine generator deg furthermore plug hybrid electric vehicles evs implemented customer side full order observer utilized estimate supply error estimated supply error considered frequency domain high frequency component reduced bess low frequency component supply error mitigated using deg two controllers implemented proposed system control system frequency reduce supply error epsilon multi objective genetic algorithm epsilon moga applied optimize controllers parameters performance proposed control scheme compared recent well established techniques pid controller tuned quasi oppositional harmony search algorithm qohsa effectiveness robustness hybrid power system investigated various operating conditions
alpha protein kinase also known alpha kinase alpk associated chronic kidney disease ckd myocardial infarction gout type diabetes mellitus addition inductive effect proinflammatory cytokines monocytic thp cells alpk expressed abundantly mouse testes low testosterone levels commonly associated arthritis ckd type cardiovascular disease inflammation testosterone anti inflammatory effect demonstrated reduce proinflammatory cytokines adhesion molecules study found alpk transgenic mice showed lower levels testosterone testes serum decreasing endogenous alpk enhanced testosterone levels transcripts testosterone regulated genes pscc beta hsd beta hsd star insl leydig cells contrast increasing testosterone decreased alpk monocytic thp cells decrease accompanied reduction proinflammatory cytokines increased alpk levels attenuated testosterone effects thp cells finally also found alpk increased release tnf alpha tgf beta human embryonic kidney cells testosterone inhibited alpk primary kidney cells taken together data suggests balance alpk testosterone plays critical role testosterone mediated inhibition proinflammatory cytokines elsevier ltd rights reserved
obesity headache two highly prevalent diseases adults children associated strong personal social impact many studies suggest obesity comorbid headache general migraine particular obesity seems risk factor migraine progression migraine frequency adults children research shows multiple areas overlap migraine pathophysiology central peripheral pathways regulating feeding inflammatory mediators calcitonin gene related protein cgrp neurotransmitters serotonin peptides orexin adipocytokines adiponectin adp leptin could explain common pathogenesis paper discussed association obesity migraine analysis recent studies children reviewed data literature order assess association obesity headache clarify possible common pathogenic mechanisms
introduction postpartum depression prevalent disorder affecting many women reproductive age despite increasing public awareness frequently underdiagnosed undertreated leading significant maternal morbidity adverse child outcomes identified postpartum depression usually treated major depressive disorder many studies identified postpartum period high risk first presentations relapses bipolar disorder areas covered article reviews acute prophylactic treatment postpartum major depressive disorder bipolar depression major depressive disorder mixed features safety antidepressant mood stabilizing medications pregnancy breastfeeding also reviewed expert commentary differentiating postpartum major depressive disorder postpartum bipolar depression difficult given clinical similarities accurate identification vital initiating proper treatment antidepressants mainstay drug treatment postpartum major depressive disorder yet randomized controlled trials shown conflicting results paucity evidence exists effectiveness antidepressant prophylaxis prevention recurrences major depressive disorder mood stabilizing medications reduce risk postpartum bipolar depression relapse randomized controlled trials examined use acute prophylactic treatment postpartum bipolar depression
aim identify relationship deiodinase thrala genetic variant thyroid hormone levels biochemical hypothyroidism preeclampsia materials methods genotyped women preeclampsia normal pregnant women using pcr rflp serum thyroid hormone levels determined using elisa results study showed higher tsh levels lower levels women preeclampsia compared normal pregnant women statistical significance women mild severe preeclampsia risk develop pregnancy induced hypertension pih mild severe preeclampsia increased carriers least one ala allele tsh levels significantly higher levels significantly lower preeclamptic women severe preeclampsia carried ala allele compared non carriers pregnant women pih mild preeclampsia carriers least one ala allele delivered lower gestational age neonates lower birth weight compared non carriers results statistically significant severe preeclampsia conclusion thrala genetic variant associated severity obstetric outcome preeclampsia also influences thyroid hormone levels study demonstrates non thyroidal biochemical hypothyroidism result deiodination effects due genotypes
last year seen great progress understanding upper airway disease management allergic rhinitis authors focused prediction effect natural course disease new evidence published disease modifying effect allergen immunotherapy terms avoidance new sensitizations prevention asthma either randomized real life studies specifically patients house dust mite allergies often underestimated difficult diagnose efficacy house dust mite sublingual immunotherapy tablets demonstrated patients allergic rhinitis asthma first time allergen immunotherapy significantly reduced asthma exacerbations patients chronic rhinosinusitis novel endotyping approach purely based helper cell biomarkers developed shown clinical relevance associations asthma comorbidity recurrence surgery severe nasal polyposis high risk asthma comorbidity disease recurrence characterized type inflammatory patterns including ige antibodies staphylococcal superantigens several studies using biologic agents targeted exactly spectrum mediators goes parallel new knowledge even type mediators derived epithelial cells expand number possible candidates innovative intervention
teach computer programming students aged years course structured two units first second term consisting two minute sessions per week conducted weeks course combines lectures practical exercises every year conduct survey following first term two minute sessions per week held weeks survey results show students consider insufficient understanding programming think good programming response adopted implemented part computer science unplugged unplugged method considered effective way teaching information science however although unplugged generated considerable results motivating students learn initial learning feel sufficiently connected full fledged programming languages java accordingly propose new method advancing unplugged full fledged programming proposed method begins conducting unplugged activity continues writing program theme abstraction java paper describe thinking concepts behind proposed method
response inhibition ability override planned already initiated response hallmark executive control deficits favour impulsive behaviours may detrimental individual life article reviews behavioural computational guises response inhibition focuses inhibition oculomotor responses first reviews behavioural paradigms response inhibition eye movement research namely countermanding antisaccade paradigms proven useful tools study response inhibition cognitive neuroscience psychopathology briefly reviews neural mechanisms response inhibition two behavioural paradigms computational models embody hypothesis theory mechanisms underlying performance behavioural paradigms well provide critical analysis strengths weaknesses models discussed models assume race decision processes decision process paradigm wins race depends different mechanisms shown response latency stochastic process proven important measure cognitive control processes involved response stopping healthy patient groups inhibitory deficits different brain diseases reviewed including schizophrenia obsessive compulsive disorder finally new directions suggested improve performance models response inhibition drawing inspiration successes models domains article part themed issue movement suppression brain mechanisms stopping stillness
mindfulness known decrease anger aggression self compassion related relatively new construct may predict clinical outcomes strongly mindfulness little research focused whether self compassion related anger aggression studies explored mechanisms associations current survey study explores whether angry rumination mediates unique associations self compassion anger aggression controlling trait mindfulness two hundred one undergraduates completed questionnaires assessing self compassion mindfulness angry rumination recent anger aggression supporting hypotheses angry rumination mediated associations self compassion particularly identification subscale anger aggression controlling mindfulness mindfulness predict angry rumination recent anger aggression controlling self compassion furthermore multiple regression analyses predicting aggression related variables indicated angry rumination uniquely predicted identification one six self compassion subscales findings suggest self compassion particularly lack cognitive emotion fusion may proximal predictor clinical outcomes mindfulness implications current conceptualizations measures mindfulness discussed self compassion may useful developing clinical interventions targeting anger aggressive behavior
altered social emotional functioning considered play important role development maintenance anorexia nervosa recently increasing interest investigating role intranasal oxytocin social emotional processing present study aimed investigate effects intranasal oxytocin interpretation expression emotions among people thirty women age matched healthy women took part present study used double blind placebo controlled cross design participants received single dose intranasal oxytocin one session placebo spray fifteen minutes administration participants completed reading mind eyes test assess interpretation complex emotions mental states followed video task assessed expressions facial affect viewing humorous sad film clips intranasal oxytocin significantly influence expression interpretation emotions healthy comparison groups group expressed significantly less positive emotion spent time looking away reported experiencing significantly negative affect response film clips finding intranasal oxytocin little effect interpretation expression emotions either group supports notion effects oxytocin social emotional processing straightforward may depend individual environmental differences well emotion processed replication findings necessary explore effect timing effects oxytocin firm conclusions drawn nonetheless findings add steady accumulation evidence people reduced emotional expression avoidance emotionally provoking stimuli
well known optimizing network topology switching transmission lines improves efficiency power delivery electrical networks fact usa energy policy act section states united states encourage appropriate deployment advanced transmission technologies including optimized transmission line configurations many authors studied problem determining optimal set transmission lines switch minimize cost meeting given power demand direct current model power flow problem known literature direct current optimal transmission switching problem ots research ots focused heuristic algorithms generating quality solutions application ots crucial operational strategic problems contingency correction real time dispatch transmission expansion mathematical theory ots problem less well developed work formally establish ots hard even power network series parallel graph one load demand pair inspired kirchoff voltage law provide cycle based formulation ots use new formulation build cycle induced relaxation characterize convex hull cycle induced relaxation characterization provides strong valid inequalities used cutting plane approach solve ots give details practical implementation show promising computational results standard benchmark instances
background debate concerns whether eating disorders increasing prevalence role socio economic status ses adolescent eating disorders another matter debate aims ascertain whether self reported eating disorders symptoms increased prevalence adolescent population early early methods person identifiable classroom survey adolescent mental health cohort study carried among graders comprehensive schools tampere finland academic year replicated among graders academic years eating disorders elicited questionnaires tailored according dsm criteria anorexia nervosa bulimia nervosa results changes observed prevalence anorexia bulimia symptoms anorexia bulimia proportion adolescents received treatment due eating disorders among girls boys eating disorders treatment contacts due eating disorders eating disorder symptoms systematically associated either low high parental socio economic status conclusion based dataset eating disorders increasing adolescent population adolescent eating disorders associated socio economic status family
objectives evaluate effect weight body mass index bmi efficacy levonorgestrel emergency contraception methods data two large multicenter randomized controlled trials designed assess emergency contraceptive efficacy pooled evaluate effect weight bmi pregnancy rates among women received levonorgestrel descriptive methods comparison means distributions according pregnancy status pregnancy rates across weight bmi categories well cubic spline modeling used describe relationship pregnancy risk weight bmi results analysis population comprised women among pregnancies reported women levonorgestrel effective preventing pregnancy significantly higher mean body weight bmi women become pregnant groups respectively statistical modeling demonstrated steep increase pregnancy risk starting weight near reach risk pregnancy greater around similar results obtained statistical modeling bmi well two studies analyzed individually conclusions analyses showed significant drop efficacy levonorgestrel emergency contraception increasing body weight pregnancy risk higher weight categories similar expected rates absence contraception like body weight increasing bmi highly correlated increased pregnancy risk elsevier inc rights reserved
release precipitation climatology global precipitation climatology centre gpcc based climatological normals rain gauges allows quantification mean land surface precipitation part global water cycle gpcc release bulk climatological correction applied compensate gauge undercatch paper derive improved correction approach based synoptic weather reports period compared results show climatological approach tends overestimate correction central eastern europe especially northern winter regions throughout year applying mean weather dependent correction gpcc uncorrected precipitation climatology gives value precipitation per year excluding antarctica global land surface warming nearly relative pre industrial temperatures expected accompanied increase global land ocean precipitation however comparison climatology year reference periods reveals significant trend land surface precipitation may caused large variability precipitation varying data coverage time issues related sampling rain gauge networks gpcc continues enlarge improve quality database generate precipitation analyses homogeneous data coverage time another way reduce sampling issues combination rain gauge based analyses remote sensing satellite radar datasets
study metal bioaccumulation gills european chub squalius cephalus conducted september medium sized rural river sutla characterized agricultural municipal type water contamination concentration ranges established first time soluble metabolically available fractions chub gills metals environmentally extremely relevant yet seldom studied follows decreasing order concentrations also determined agreement previous reports application general linear modelling influence different abiotic metal exposure level biotic parameters fish sex age size condition metal bioaccumulation tested established bioaccumulation many metals fish depended various physiological conditions wherein could singled metal exhibiting strongest association one biotic parameters significantly higher smaller fish however also undoubtedly demonstrated concentrations three metals applied reliable indicators metal exposure even conditions low moderate water contamination observed sutla river nonessential elements essential element results study present important contribution maintenance high ecological status european freshwaters enrichment knowledge bioaccumulation various metals gills european chub frequently applied bioindicator species monitoring water pollution
study examined whether grouping people meaningful social scenes two people chat impacts basic perceptual analysis partaking individual explore issue measured neural activity using functional magnetic resonance imaging fmri participants sex categorized congruent well incongruent person dyads two people interacting plausible implausible manner incongruent person dyads elicited enhanced neural processing several high level visual areas dedicated face body encoding posterior middle temporal gyrus compared congruent person dyads incongruent congruent person scenes also successfully differentiated linear multivariate pattern classifier right fusiform body area left extrastriate body area finally increases person scenes meaningfulness judged independent observers accompanied enhanced activity bilateral posterior insula findings demonstrate processing person scenes goes beyond mere stimulus bound encoding partaking agents suggesting changes relations agents affect representation category selective regions visual cortex beyond elsevier ltd rights reserved
several studies found coercive sexting increases probability victimized within dating relationship study focused perpetrator perspective instead aimed investigate relationship specific sexting behavior sharing someone else sexts without consent dating violence perpetration specifically aimed test moderation role benevolent hostile sexism relationship study involved italian participants years age age females completed survey composed socio demographic data sexting behavior scale conflict adolescent dating relationships inventory ambivalent sexism inventory results highlighted relationship allowed sharing sexts dating violence perpetration benevolent sexism could protective factor contrary hostile sexism could risk factor controlling age gender sexual orientation findings suggested existence factors linked sexting behaviors factors could implications prevention programs elsevier ltd rights reserved
study investigates supply chain member strategic choice price leadership price followership supply chain partners particular investigation focuses whether retailer ever incentive asymmetric price leadership types across multiple suppliers even absence asymmetry across demand cost competitive pricing behavior analyzing game theoretic model composed two manufacturers one common retailer show retailer always prefer price leadership manufacturer retailer strategic choice price leadership one manufacturer depends upon price leadership type competing manufacturer degree product substitutability surprisingly although competing manufacturers completely symmetric demand cost characteristics retailer price leadership one manufacturer prefers price leader manufacturer product substitutability sufficiently low resulting asymmetric price leadership despite asymmetry manufacturers hand higher degrees product substitutability lead retailer choose seek price leadership either manufacturer contrast manufacturer always finds profitable price leader retailer regardless product substitutability price leadership situation retailer competing manufacturer strategic choices vertical price leadership reflect interesting interplays product positioning supply chain members pricing objectives foresights supply chain members pricing behavior elsevier rights reserved
compressed air irreplaceable energy source manufacturing processes also common applications even alternatives result compressed air key utility manufacturing industry unfortunately cost compressed air production one expensive processes manufacturing facility order reduce compressed air generation cost unconventional way using microturbine configuration proposed concept based extraction certain amount compressed air compressor residual air flowing turbine produce sufficient back power drive compressor thermodynamic life cycle analysis presented several system variations including simple cycle without recuperator complex configuration intercooler recuperator reheating study based typical requirements quantity pressure small medium sized industrial compressed air system analysis focused north american market due low price natural gas lowest life cycle cost alternative represented microturbine concept recuperator air extraction partial compression intercooler aftercooler comparison electric motor conventional microturbine prime movers demonstrates economic benefit proposed compressed air generation method design parameters utility prices considered elsevier ltd rights reserved
construction sector great potential reduce total energy consumption techniques applied sustainable projects world policy makers already realized potential begun setting governmental goals since new regulations achieving sustainability recently set change conventionally practiced administrative patterns construction sector number claims related sustainability features construction projects growing ever since construction contracts playing critical role preventing types legal administrative risks lead claims result changes caused need alterations industry contractual practices since alterations new field one however find limited number researches studying analyzing possible regulatory risks associated green projects consequent probable legal claims result present research intends fill gap literature identifying risk factors may lead claims sustainable construction also assessing criticality factor basis opinions industry professionals analyzing factors relative importance index method findings study aim increase level awareness construction professionals probable risks revealing possible legal risks sustainable projects study shall also assist various parties contract drafting particular conditions accordingly order prevent probable future claims elsevier ltd rights reserved
objective examine event related brain potentials erps multiple sclerosis visual back working memory task test hypothesis compensatory brain function may associated variance task performance patients methods midline erps patients hcs obtained visual back task placed increasing demands back behavioral measures neuropsychological performance measures also obtained results patients slower reaction times rts hcs back task accuracy back neuropsychological tests differ groups erp amplitude decreased groups demand increased patients lower overall amplitudes compared hcs anteriorization amplitude associated better back performance amplitudes also related neuropsychological test performance conclusions patients reduced erp amplitude compared hcs back changes erp anterior posterior midline amplitude distribution associated cognitive performance international federation clinical neurophysiology published elsevier ireland ltd rights reserved
objective easy use easy comprehend assessment methods measuring shared understanding teams hard find paper describes experiment measure called shared priorities based ranking self generated strategic items assessed trained teams compared non trained teams dynamic problem solving task maturity participating teams also assessed using content analysis measure shared priorities measure used alongside well documented measures team awareness based self rating results show shared priorities measure correlates task performance could also distinguish trained nontrained teams however shared priorities measure correlate team measures cars crew awareness rating scale datma distributed assessment team mutual awareness suggesting captures different quality teamwork self rating measures shared priorities measure found easily administered
paper proposes parallelized online optimization low voltage distribution network lvdn operation performed graphics processing unit gpu combining optimization procedure load flow method case study performed test lvdn distributed generators dgs controllable loads differential evolution optimization based backward forward sweep load flow method parallelized gpu goal online optimization keep lvdn voltage profile within prescribed limits minimize lvdn losses enable demand response functionality achieved optimization determined reference values controllable load operation reactive power generation active power curtailment dgs results show parallelized gpu implemented optimization significantly faster similar implementation central processing unit therefore suitable online optimization presented lvdn
work studies potential using intra cycle recirculation partial oxidation products repox control combustion phasing advanced internal combustion engine combustion systems hcci partial oxidation products created extracting portion lean charge products expansion stroke mixing fuel auxiliary chamber repox prechamber equivalence ratio recirculated reactants controlled varying amount mass extracted recirculated partially oxidized products reintroduced main chamber mixed compressed air facilitate main chamber reaction process modeled using chemkin pro software package combined external program balance mass energy repox system heptane modeled detailed reaction mechanism used fuel effects extraction mass extraction timing injection timing prechamber volume overall equivalence ratio examined varying prechamber volume show effect performance combustion phasing conditions assumptions study whereas injection timing extraction mass extraction timing found significant effects combustion phasing indicating repox concept could possibly used control hcci derivative internal combustion engine combustion systems significant effect achieved varying extraction mass increasing extraction mass advanced combustion phasing degrees crank angle repox system also found increase lean limit equivalence ratio compared conventional hcci without specific optimization lean operation
studies addressed whether stress associated physiological changes caregivers reversible psychological interventions mitigating distress report pro inflammatory sympathetic oxidative stress gene expression response stress management caregivers allogeneic hematopoietic stem cell transplant allo hsct patients following randomization permuted block either treatment usual tau stress management intervention psychoeducation paced respiration relaxation peprr twenty four caregivers selected conclusion larger trial caregivers peprr provided one one beginning around transplant genome wide transcriptional profiling conducted peripheral blood mononuclear cells collected prior randomization completion peprr months post transplant bioinformatics analysis differentially expressed genes indicated reduced activity transcription control pathways associated inflammation kappa sympathetic nervous system creb oxidative stress nrf caregivers receiving peprr compared tau aligning reductions stress depression anxiety suggests peprr may alter transcriptomic effects reported distressed individuals
paper proposes novel dual consequent pole vernier memory machine dcp vmm featuring alternatively arranged ndfeb low coercive force lcf magnet poles rotating stationary sides respectively due presence lcf magnets repetitively magnetized demagnetized via simple current pulse extra high torque density low speed excellent high efficient high speed flux weakening performance simultaneously realized configuration operating principle well design considerations proposed machine introduced respectively finite element method fem coupled nonlinear analytical hysteresis model lcf magnets employed investigate electromagnetic performance machine verifies effectiveness machine design feasibility competent candidate automotive applications
physiological conditions endothelium generates vasodilator signals prostacyclin nitric oxide endothelium dependent hyperpolarization edh regulation vascular tone relative importance two signals depends diameter blood vessels diameter arteries decreases contribution edh regulation vascular tone increases mechanism involved edh varies species blood vessel types nevertheless activation endothelial intermediate small conductance calcium activated potassium channels ikca skca respectively characteristic edh pathway ikca skca mediated edh reduced endothelial dysfunction develops ageing hypertension less pronounced female age matched male menopause impaired edh mediated relaxation related reduced involvement skca response becomes dependent ikca latter depends activation adenosine monophosphate activated protein kinase ampk silent information regulator sirt proteins associated process cellular senescence vascular signalling response female hormone understanding role ampk sirt edh like responses may help identifying effective pharmacological strategies prevent development vascular complications different aetiologies
paper presents pulse compression radar baseband analog signal processing integrated silicon process low cost power dissipation analog signal processing circuitry exhibits autocorrelation properties polyphase codes maximizes sensitivity resolution pulse radar system alleviates speed resolution requirements analog digital converter adc via analog correlator circuitry includes two stage variable gain amplifier vga high dynamic range correlator integrator circuit comparator offset calibration circuits differential bit vga designed adaptively track friis path loss rapid change vga gain offset calibration relaxing dynamic range requirements correlator measured performance shows vga gain variation vga group delay imbalance states high speed pulse compression correlation performed analog current domain speed requirement adc reduced factor equal duty cycle lowering adc power consumption chip fabricated process wire bonded printed circuit board tested stratix field programmable gate array board evaluate system performance different radar polyphase codes
healthcare reimbursement increasingly tied value service critical genetic counselor profession demonstrate value added gcs outcomes research conducted rapid systematic literature review identify outcomes genetic counseling web science including pubmed cinahl databases systematically searched identify articles meeting following criteria measures assessed genetic counseling pre post design comparisons made group non group comparative cohort design genetic counseling outcomes could assessed independently genetic testing outcomes genetic counseling conducted masters level genetic counselors non physician providers twenty three papers met inclusion criteria majority studies cancer genetic setting commonly measured outcomes included knowledge anxiety distress satisfaction perceived risk genetic testing intentions receipt health behaviors decisional conflict results suggest genetic counseling lead increased knowledge perceived personal control positive health behaviors improved risk perception accuracy well decreases anxiety cancer related worry decisional conflict however studies needed evaluate wider array outcomes diverse genetic counseling settings
structural dynamics dna hairpin studied absence presence two natural osmolytes trimethylamine oxide tmao urea ambient extreme environmental conditions including high pressures high temperatures using single molecule forster resonance energy transfer fluorescence correlation spectroscopy effect pressure conformational dynamics dna investigated single molecule level providing novel mechanistic insights conformational conversions different canonical dna duplex structures similar melting points dna found rather pressure sensitive combined temperature pressure dependent data allow dissection folding free energy enthalpic entropic volumetric contributions folded conformation effectively stabilized compatible osmolyte tmao high temperatures also high pressures presence destabilizing solute urea
purpose review outline current guidelines evaluation treatment nocturia nocturnal polyuria currently consensus definition often reported either nocturnal urine production nup nocturnal polyuria index npi clinical trials oral dispersible desmopressin melt demonstrate utility pharmacological treatment refractory nocturnal polyuria also introduce risk hyponatremia currently unapproved usa nocturia prevalent condition shows increased risk age associated increased mortality decreased quality life nocturia managed first classifying cause either global polyuria nocturnal polyuria diminished bladder capacity sleep disorder mixed etiology bladder diaries specifying etiology effective nocturia treatment dependent cause determined case case basis treatment recommendations include addressing comorbidities behavioral therapy pharmacological therapy surgical intervention
note historical view bejan numbers presented two definitions bejan number field thermodynamics fluid mechanics heat transfer mass transfer general form bejan number introduced application bejan number flows porous media shown note concludes critical discussion view bejan number convection combination euler reynolds numbers elsevier ltd rights reserved
chronic hepatitis chc infection poses global healthcare burden associated serious complications untreated prevalence hepatitis virus hcv infection highest areas central south east asia hcv patients worldwide live region hcv genotypes prevalent treatment outcomes chronic hepatitis vary ethnicity asian patients achieve higher sustained virologic response rates following interferon ifn based therapy non asians however low efficacy poor safety profile subcutaneous administration limit use ifn based therapies superior virologic outcomes observed different classes direct acting antivirals daas alone combination several oral daa regimens available asia regimens shown excellent efficacy favorable tolerability clinical trials yet need studies daas real world context particularly asia furthermore ifn free treatment may accessible many patients region ifn based regimens remain option countries need improve current clinical practices hcv management asia including effective screening disease awareness prevention programs understand cost effectiveness ifn free regimens evolution potent treatments makes hcv eradication possibility available patients however access therapies asian countries slow primarily economic barriers continue present hurdle optimal treatment
mindreading refers ability attribute mental states including thoughts intentions emotions oneself others essential navigating social world empirical mindreading research predominantly featured children groups autism spectrum disorder clinical samples many standard tasks suffer ceiling effects neurologically typical adults first outline case studying mindreading adults proceed review tests emotion perception cognitive affective mentalizing multidimensional tasks combining facets focus selected examples core experimental paradigms including emotion recognition tests social vignettes narrative fiction prose film participative interaction real virtual worlds highlighting challenges studies adult cohorts conclude naturalistic multidimensional approaches may productively applied alongside traditional tasks facilitate nuanced picture mindreading adulthood ensure construct validity whilst remaining sensitive variation upper echelons ability
purpose purpose paper identify risks challenges related change building construction projects european union zero energy building nzeb decree year another goal create solutions risks challenges design methodology approach workshop method chosen gather date information construction cluster finland findings workshop main concern level knowledge know parties working construction projects answer challenge serious substantial education organisations competence requirements designers piloting much possible next years offered commissioning consultant also seen vital nzeb project tight schedules unfit project delivery systems also seen risk nzeb projects however modern project delivery systems seen problematic practice even functional theory originality value results workshop valuable parties working building construction projects finland whole area
one main characteristics seismic waves apparent wave velocity great influence seismic responses long span suspension bridges understanding influences important seismic design article critical issues concerning traveling wave effect analysis first reviewed taizhou bridge longest triple tower suspension bridge world taken example investigation three dimensional finite element model bridge established abaqus lanczos eigenvalue solver employed calculate structural dynamic characteristics traveling wave effect seismic responses long span triple tower suspension bridges investigated envelopes seismic shear force moment longitudinal direction along three towers relative displacements towers girder reaction forces bottoms three towers different apparent wave velocities calculated presented detail results show effect apparent wave velocity seismic responses triple tower suspension bridge fluctuates velocity lower effects turn stable velocity becomes larger addition effects traveling wave closely related spectral characteristics propagation direction seismic wave seismic responses components closer source relatively larger therefore reliable estimation seismic input apparent wave velocity according characteristics bridge site significant accurate prediction seismic responses study provides critical reference seismic analysis design long span triple tower suspension bridges
emerging enduring conditions motherhood taiwan shape mothers interactions children gender sexually nonconforming bridging research transformation mothering discourses taiwan globally small growing body work lgbt family origin relationships article argues women experiences raising gender sexually nonconforming children integrally shaped conditions gender family inequality lives inequalities sometimes challenged often reinscribed new parenting discourses resources proliferated late early century taiwan including new forms parental labor accountability child outcomes emerging expert voices sexuality parenthood analysis rooted ethnographic fieldwork family history interviews gender sexually nonconforming people families origin throughout taiwan emphasis heterosexual mothers narratives
metallic shaped connectors properly placed sculptured grooves used nowadays restoring damaged connections parthenon temple grooves filled suitable cement mortar study mortar reinforced multi walled carbon nanotubes effort develop smart material could monitor structural integrity connection measuring electrical resistance electrical resistance change erc technique connection subjected shear using properly designed metallic restraining loading system erc technique used conjunction traditional electrical strain gauges clip gauges innovative sensing techniques digital image correlation acoustic emission data obtained erc technique good qualitative agreement respective ones provided traditional innovative techniques moreover overall variation erc well compatible load applied indicating specific quantity could flexible tool monitoring strain damage restored connections copyright authors published elsevier
appearance pressures experienced fashion models criticized harmful health well increasing eating disorder risk among youth promoting ideals extreme thinness given recent legislation protect models undertook strategic science study assess professional fashion models perceptions potential impact feasibility seven policy proposals sample female fashion models mean age years completed online survey assessing unhealthy weight control behaviors uwcb perceived pressure agencies lose weight well perceived impact feasibility seven potential policy actions chi squared analyses multivariable logistic regressions compared uwcb among models asked lose weight friedman kendall tests conducted examine differences impact feasibility ratings across seven policy proposals models reported high levels pressure lose weight associated higher odds engaging uwcb policy approaches rated impactful increase worker protections though rated moderately feasible requiring employers provide food min break jobs longer rated impactful feasible imposing restrictions minimum bmi rated least impactful approaches providing employment protections healthier working conditions supported professional models findings help illuminate viable policy approaches perspective key stakeholders
computer aided process planning capp important bridge computer aided design cad computer aided manufacturing cam computer integrated manufacturing environment operation sequence generation one difficult tasks capp aim operation sequencing capp determine best order machining operations minimal manufacturing cost satisfying precedence constraints paper presents proposed method optimizing operation sequence using modified clustering algorithm key concept method precedence constraints firstly checked selecting possible next operations last operation sequence traveling costs compared choose optimal feasible operation minimum traveling cost sequence operation sequences calculated total traveling cost obtaining optimal sequence result removing unfeasible sequences beginning procedure selecting optimal operation sequence step time significantly reduced capability performance proposed method demonstrated three specific case studies comparisons show proposed method solve problem much lesser computational time generating alternate optimal feasible sequences previous algorithms
background development disturbances skin microcirculation type diabetes well characterised assessed skin microcirculation longitudinally onset diabetes years duration investigate disturbances start material methods seventeen adult patients type diabetes participated skin microvascular function digit left hand investigated laser doppler fluxmetry ldf arbitrary units ldf carried rest following one min arterial occlusion time peak ldf percentage increase ldf post occlusive reactive hyperaemia prh determined retinopathy assessed fundus photographs ophthalmoscopic recordings results skin microvascular function remained normal first five years compared baseline non diabetic reference group time peak ldf prolonged years diabetes prh lower reference group years lower baseline years diabetes one patient developed retinopathy first signs found years diabetes conclusions functional disturbances total skin microcirculation observed seven years patients type diabetes preceded diabetic complications retinopathy
postoperative pulmonary complications ppcs common costly increase patient mortality changes respiratory system occur immediately induction general anaesthesia respiratory drive muscle function altered lung volumes reduced atelectasis develops patients receiving neuromuscular blocking drug respiratory system may take weeks return preoperative state general anaesthesia major surgery risk factors ppc development numerous clinicians aware non modifiable modifiable factors order recognize risk optimize care many validated risk prediction models described useful improving understanding ppc development remains inadequate consensus useful clinically preventative measures include preoperative optimization morbidities smoking cessation correction anaemia addition intraoperative protective ventilation strategies appropriate management neuromuscular blocking drugs protective ventilation includes low tidal volumes must calculated according patient ideal body weight evidence beneficial level peep required going randomized trials hopefully provide information peep used may useful precede recruitment manoeuvre atelectasis suspected high risk patients surgical time minimized surgery nasogastric tubes avoided analgesia optimized postoperative mobilization chest physiotherapy oral hygiene bundle reduces ppcs
relay autotuner provides simple way finding pid controller parameters even though relay autotuning much investigated literature practical aspects well documented paper asymmetric relay autotuner features startup procedure adaptive relay amplitudes proposed parameter choices handling noise disturbances start non steady state possible error sources discussed autotuner implemented tested industrial air handling unit show use practice experiments show good results prove proposed simple autotuner well suited industrial use experiments also enlighten possible error sources remaining problems elsevier ltd rights reserved
paper considers risk incurring future medical expenditures light family resources available pay expenditures well choice health insurance model non premium medical pocket expenditures use estimates model develop prospective measure medical care economic risk estimating proportion families risk incurring high non premium pocket medical care expenses relation resources use estimates model compare extent different types insurance mitigate risk incurring non premium expenditures providing increased utilization medical care find families lack resources pay median expenditures insurance type lack resources pay percentile expenditures insurance type also find mediating effect insurance non premium expenditures outweigh associated premium expense expenditures employer sponsored insurance direct purchase insurance younger age expenditures medicare supplementary plans aged older published article government work public domain usa
using latino national survey lns study analyzes existence gender gap favor men monetary remittance behavior hispanics residing united states findings indicate cultural gender norms expectations country origin play key role study shows women migrants less likely remit men transfer smaller amounts remittance gender gap universal among subgroups since observable among hispanics came improve economic situation plan return home country low income low schooling index migrants perceptions gender roles proxy cultural gendered norms constructed shows traditional gender views associated significant gender gap favor men remittances
background aims epidemiological studies analyzed association carotid intimamedia thickness cimt insulin resistance glucose levels glycated hemoglobin mixed results aimed evaluate association cimt homeostasis model assessment insulin resistance homa fasting post load plasma glucose glycated hemoglobin brazilian longitudinal study adult health elsa brasil baseline methods included participants aged years without diabetes overt cardiovascular disease complete cimt data baseline built crude adjusted linear binary logistic models evaluate association cimt homa fasting plasma glucose post load plasma glucose glycated hemoglobin also built post hoc models stratified sex results fully adjusted linear models association cimt homa remained significant beta confidence interval consistent results association highest age sex race specific cimt quartile homa significant adjusted logistic model odds ratio association homa highest cimt quartile remained significant sex specific analyses men women find independent association cimt glucose glycated hemoglobin conclusions found direct association homa cimt large sample nondiabetic participants mechanisms unrelated glucose homeostasis direct effect insulin atherosclerosis medial hypertrophy may involved elsevier rights reserved
background venous thromboembolism vte common complication manifests hospitalization well postsurgeries including orthopedic surgeries edoxaban new oral direct factor inhibitor recently approved treating vte patients already treated parenteral anticoagulant prevention stroke non central nervous system systemic embolism patients nonvalvular atrial fibrillation objectives purpose systematic review evaluate safety efficacy edoxaban vte prophylaxis lower limb orthopedic surgery materials methods comprehensive search conducted google scholar pubmed medline sciencedirect identify potential records titles abstracts full texts screened using inclusion criteria filter irrelevant studies moreover data extraction quality assessment undertaken using standardized tools results narratively synthesized presented tables results six studies included systematic review screening records majority studies demonstrated statistically significant reduction vte events edoxaban group compared dalteparin placebo enoxaparin groups conclusion study helped amalgamate evidence regard use edoxaban vte prophylaxis post lower limb orthopedic surgery line results reviewed studies edoxaban seems highly effective reducing vte post lower limb orthopedic surgery
defect management central task software maintenance defect reported appropriate resources must allocated analyze resolve defect important issue resource allocation estimation defect resolution time drt prior research considered different approaches drt prediction exploiting information retrieval techniques similarity textual defect descriptions article investigate potential text clustering drt prediction build study published raja demonstrated clusters similar defect reports statistically significant differences drt raja study also suggested difference clusters could used drt prediction aims twofold first conceptually replicate raja study assess repeatability results different settings second investigate potential textual clustering issue reports drt prediction focus accuracy using different data sets different text mining tool clustering technique first conduct independent replication original study design fully automated prediction method based clustering simulated test scenario check accuracy method results independent replication comparable original study confirm initial findings regarding significant differences drt clusters defect reports however simulated test scenario used assess prediction method yields poor results terms drt prediction accuracy although replication confirms main finding original study attempt use text clustering basis drt prediction achieve practically useful levels accuracy
study assesses relationship prosocial motivation commitment change among youth care professionals draw person environment fit theory propose relationship conditional employees perceived meaningfulness change society clients results confirm expected positive relationship prosocial motivation commitment change analysis suggests moderating relationship prosocial motivation client meaningfulness commitment change understood substitutive relationship prosocial motivation client meaningfulness sufficient conditions presence necessary condition commitment change
evaluated resistance two samples trip steel prepared laboratory conditions faculty metallurgy materials engineering fmme technical university ostrava czech republic sour environment containing first steel investigated composition second steel composition trip steels characterized using yield strength range mpa tensile strength range mpa trip steel samples form sheets thickness residual austenite content respectively two steels studied resistance hydrogen embrittlement evaluated sour environment contained hydrogen sulphide using hydrogen induced cracking hic sulphide stress cracking ssc tests performed accordance nace standards trip steels showed high resistance hydrogen embrittlement ssc cracks observed cracking arising hic observed steels measured parameters showed variation cases lower recommended limits cases measured parameters higher crack length ratio cracks initiated preferentially non metallic inclusions either elongated manganese sulphide particles oxide stringers rich
introduction migraine headaches common children adolescents current pharmacologic treatment options limited despite prevalence debilitating effects pediatric migraine cognitive behavioral therapy cbt evidence based practice focuses development coping strategies cognitive restructuring alter pain experience till date meta analysis done examine use cbt pediatric migraine methods using keywords cognitive behavioral therapy cognitive behavior therapy cognitive behavioral therapy cognitive behavior therapy cbt headache migraine preliminary search pubmed ovid database yielded articles published english jan may full articles also reviewed references interest data extraction studies included meta analysis results results meta analysis well support clinical role cbt management pediatric migraine pooled odds ratios clinically significant improvement greater headache activity reduction post treatment follow months later respectively demonstrating significant clinical improvement cbt compared wait list control placebo standard medication furthermore clinical improvement stable even year follow evident studies conclusion good evidence cbt beneficial children suffering migraine may also augment efficacy standard medications amitriptyline
background trauma depression associated neurocognitive alterations combined effect neurocognition unclear investigated separate interactive associations trauma depression neurocognition sample ethnically diverse urban dwellers explored impact age effects methods adults aged divided groups based current depression trauma history individuals meeting dsm criteria depression considered depressed individuals rated diagnostic interview trauma history considered positive trauma resulting principal component analysis neuropsychological scores resulted factor solution representing verbal learning memory recognition verbal lmr visual learning memory recognition speeded attention cognitive flexibility accounting variance results multivariable linear regressions adjusting age revealed trauma regardless depression associated worse verbal lmr performance trauma association driven verbal list prose passages learning memory recognition memory age stratified years regressions revealed trauma association significant older adults main interactive effects depression observed conclusions trauma regardless depression associated worse verbal learning memory recognition performance results suggest trauma exposure may negatively impact neurocognition clinicians working adults urban settings query trauma addition depression considering subjective objective measures neurocognitive functioning particularly older adults elsevier ltd rights reserved
background observational studies favored percutaneous patent foramen ovale pfo closure medical treatment reduction recurrent stroke whereas randomized trials failed demonstrate significant superiority percutaneous pfo closure long term studies available post pfo closure outcome study reports long short term clinical outcomes percutaneous pfo closure methods january january enrolled men women consecutive eligible patients cerebrovascular events peripheral embolism presumably related pfos underwent percutaneous pfo closure center patients documents clinical data assessed entire study population telephone contacts applied cases mean follow time months main criterion closure patients least cryptogenic stroke peripheral embolism associated pfos results percutaneous pfo closure successfully performed patients cardiovascular cerebrovascular deaths occurred mean follow time months long term device related complications cerebrovascular accidents patients procedure open heart surgery short term complications atrial fibrillation patient air embolism hematoma tamponade conclusions percutaneous pfo closure associated low risk recurrent stroke observed cardiovascular cerebrovascular mortality however short long term device related complications thus percutaneous pfo closure safe treatment even long term
improve electromagnetic shielding effectiveness light weight carbon foam magnetic nanoparticles embedded processing developed coal tar pitch mixture coal tar pitch nickel nanoparticles sacrificial template technique heat treated degrees ascertain effect nanoparticles embedded characterized scanning electron microscopy ray diffraction raman spectroscopy vector network analyzer vibration sample magnetometer observed nanoparticles embedded carbon material play important role improving structure electrical conductivity catalytic carbonization structural investigation suggests nanoparticles embedded carbon material bulk well surface demonstrates excellent shielding response frequency range ghz total shielding effectiveness dominated absorption losses total governed absorption losses increase due increase dielectric magnetic losses ferromagnetic nanoparticles high surface area thus light weight embedded small amount magnetic nanoparticles useful material stealth technology
introduction recent advances therapeutics psoriatic arthritis psa provided options clinicians managing psa purpose review update reader treatment options psa using conventional synthetic disease modifying agents csdmards novel therapies including tumour necrosis factor alpha inhibitors interleukin inhibitor ustekinumab interleukin antagonists including secukinumab brodalumab ixekizumab phosphodiesterase inhibitor apremilast areas covered reviewed published articles treatment psa main sources data included treatment recommendations registry studies systematic literature reviews major randomised controlled trials recently approved drugs abstracts american college rheumatology eular meetings expert commentary overview evidence use various pharmacotherapeutic agents treatment heterogeneous disease compiled treatment options various domains psa also discussed
paper real time implementation fuzzy logic controller shell tube heat exchanger sthe temperature process using labview presented labview potential graphical programming gives added advantage debug problem easily sthe process controlled using fuzzy set rules embed linguistic variables proposed controller performance real time plant compared pid controller validate improvement performance process plant responses verified controllers temperature input cold water hot water peak value overshoot rise time settling time validate controller implementation
purpose interstim device food drug administration approved minimal invasive therapy sacral neuromodulation lower urinary tract dysfunction interstim implantation trial appropriate screening tests required determine patient therapy eligibility two different techniques patient screening percutaneous nerve evaluation pne test staged test studies reported success failure rates technique however test sensitivity predictive values either test studied aim study determine sensitivity specificity test establish decision algorithm appropriate testing method used screening test methods cross sectional study conducted august february included patients lower urinary tract dysfunction participated stimulation test trial patients underwent pne first stimulation test encountered technical difficulty pne electrode migration underwent staged testing results total patients including female male subjects underwent pne patients diagnoses included refractory overactive bladder nonobstructive urinary retention frequency urgency syndrome total patients screened pne patients staged testing overall sensitivity pne staged test pne specificity compared staged test positive negative predictive values pne staged test respectively conclusions pne test high specificity positive predictive value recommend pne simple office based less expensive procedure first option screening
paper discusses measurement frequency response functions various converters frequency domain identification procedure applied measured frequency responses identified transfer functions primarily used developing behavioral models converters distributed power systems based upon converters cascade parallel several configurations system level analysis complete system becomes complex identified transfer functions high order therefore certain technique needs applied order reduction identified transfer functions process order reduction ensured system retains dynamics full order system technique used based hankel singular values system systematic procedure given retain maximum energy states reduced order model dynamic analysis performed behavioral models based full reduced order frequency responses close agreement results validates effectiveness model order reduction stability key design objective system designer therefore measured frequency responses interface source load also used predict stability system
develop fabricate rail rail operational amplifier amp ultralow power operation standard complementary metal oxide semiconductor process amp two stage structure comprises complementary input stage novel cross coupled output stage cross coupled output stage increases transconductances metal oxide semiconductor field effect transistors output stage without requiring additional chip area hence increases gain amp drivability capacitive load experimental results showed gain common mode input voltage supply voltage gains obtained common mode input voltages ranging furthermore unitygain frequency khz phase margin degrees capacitive load power consumption including bias circuits
main purpose meta analysis evaluate impact ankylosing spondylitis health related quality life assessed medical outcomes short form questionnaire systematic literature search performed pubmed web science january obtain eligible studies random effect model performed summarize scores domain radar chart used compare scores patients health conditions spearman correlation analysis meta regression used explore related factors stata version spss version adopted meta analysis thirty eight studies included study reliable summarize scores pooled mean scores physical health domains ranged domains lowest highest respectively pooled mean scores mental health domains ranged domains lowest highest respectively besides physical component summary lower mental component summary basdai basfi negatively associated domains significantly patients substantial impaired hrqol comparison general population could adversely affect hrqol patients measuring hrqol considered essential part overall assessment health status patients would provide valuable clues improving management disease making decisions regarding treatment
user evaluations gained increasing importance visualization research past years many cases evaluations way support claims made visualization researchers unfortunately recent literature reviews show comparison algorithmic performance evaluations number user evaluations still low reasons required amount time conduct studies together difficulties involved participant recruitment result reporting could shown quality evaluation results simplified participant recruitment crowdsourcing platforms makes technology viable alternative lab experiments evaluating visualizations time conducting reporting evaluations still high paper propose software system integrates conduction analysis reporting crowdsourced user evaluations directly scientific visualization development process proposed system researchers conduct analyze quantitative evaluations large scale evaluation centric user interface mouse clicks thus becomes possible perform iterative evaluations algorithm design potentially leads better results compared time consuming user evaluations traditionally conducted end design process furthermore system built around centralized database supports easy reuse old evaluation designs reproduction old evaluations new additional stimuli driving challenges scientific visualization research describe system design considerations made design process demonstrate system conducting three user evaluations published visualization literature
introduction late onset hypogonadism loh represents common clinical entity aging males characterized presence symptoms usually sexual nature decreased libido decreased spontaneous erections erectile dysfunction signs combination low serum testosterone concentrations whether testosterone replacement therapy trt offered individuals still extensive debate aims aim position statement provide critically appraise evidence trt aging male focusing pathophysiology characteristics loh indications trt available therapeutic agents monitoring treatment associated risks materials methods literature review consensus expert opinion results conclusions diagnosis treatment loh justified combination symptoms testosterone deficiency low testosterone present patients receiving trt could profit regard obesity metabolic syndrome type diabetes mellitus sexual function osteoporosis undergo scheduled testing adverse events regularly potential adverse effects trt cardiovascular disease prostate cancer sleep apnea yet unclear remain investigated large scale prospective studies management aging men loh include individual evaluation comorbidities careful risk versus benefit assessment elsevier ireland ltd rights reserved
background fruit lycium cliinense one popular natural materials used counter effects musculoskeletal diseases oriental medicine particular fruit known antiaging effects significant interest research community purpose investigation observe confirm ameliorative effect osteoporosis verified vivo study methods female icr mice aged weeks surgically ovariectomized ovx induce osteoporosis weeks induction oral administration continued weeks end experiment levels bone mineral content bmc bone mineral density bmd estimated dual energy ray absorptiometry hematoxylin eosin staining performed additionally serum osteocalcin calcium concentrations analyzed results treatment significantly reduced deterioration bmc bmd compared ovx mice histological analysis showed ameliorated osteoporosis including hypertrophy epiphyseal plate additionally decreased serum osteocalcin well calcium levels recovered following administration conclusion results demonstrated ameliorates osteoporosis ovx mice improving several important parameters including bmc bmd bone turnover markers osteocalcin calcium levels serum copyright chinese medical association published elsevier taiwan llc
paper analyze discuss well posedness two new variants called sweeping process introduced moreau early moreau anal convexe montpellier motivation plasticity theory first new variant concerned perturbation normal cone moving convex subset supposed bounded variation lipschitz mapping assumptions data show perturbed differential measure inclusion one one right continuous solution bounded variation second variant large analysis made concerns first order sweeping process velocity moving set class problems subsumes particular case evolution variational inequalities widely used applied mathematics unilateral mechanics duvaut lions inequalities mechanics physics springer berlin assuming moving subset continuous variation every bounded show problem least lipschitz continuous solution well posedness class sweeping process obtained coercivity assumption involved operator also discuss applications sweeping process study vector hysteresis operators elastoplastic model kreja eur appl math planning procedure mathematical economy henry math anal appl cornet math anal appl nonregular electrical circuits containing nonsmooth electronic devices like diodes acary nonsmooth modeling simulation switched circuits lecture notes electrical engineering springer new york theoretical results supported numerical simulations prove efficiency algorithm used existence proof methodology based tools convex analysis like papers collection show presentation elegant modern convex analysis influenced moreau seminal work
ever increasing computing storage capacity smart devices enabling users perform tasks relegated devices high computing capabilities pcs laptops empowering users employ moment device best adapts concrete situation demands applications deployed provide consistent user experience users migrate one device another liquid software paradigm facilitates development kind applications however order get satisfying user experience applications also adaptable specific context user position paper presents concept liquid context contextual information migrates across devices along applications data addition also propose architecture development context aware liquid applications techniques improve usability user experience liquid applications
point cloud registration fundamental task computer graphics specifically rigid non rigid shape matching rigid shape matching problem formulated problem simultaneously aligning labelling two point clouds similar possible name problem procrustes matching problem non rigid shape matching problem formulated higher dimensional problem using functional maps method high dimensional problems difficult non convex problems currently solved locally using iterative closest point icp algorithms similar methods good initialization crucial obtaining good solution
introduction autism spectrum disorder asd behavioral syndrome caused developmental disorder biologically determined onset first three years life areas concerned mainly related social communication social interaction mutual functional symbolic play last decades different conceptions autism taken also emphasizing different sensory perceptual abnormalities basis central features disorder pilot study intends address issue sensory perception preschool children affected asd material methods asd children enrolled males female aged years years mean age control group consisted typical developing children males females mean age subjects underwent assessment sensory perceptual abilities according bogdashina sensory profile checklist revised spcr evaluation results two groups comparable age sex distribution table shows comparison two groups results spcr specifically individuals asd showed significantly higher scores near perception areas evaluated healthy controls suggesting clear perceptual impairment asd subjects olfactory perception two groups comparable conclusions significant differences behavioral reaction smell stimulation asd typical developing children result could explained according early age sample could cause high reactivity smell stimulation also typical developing examined children
article dimensional variable coefficient breaking soliton equation investigated based bell polynomials symbolic computation bilinear forms backlund transformation equation derived one two three soliton solutions obtained via hirota method soliton solutions also constructed propagation characteristics interaction behaviors solitons discussed graphically solitonic direction position depend sign wave numbers shapes multisoliton interactions scaled space time coordinates affected variable coefficients iii multisoliton interactions elastic velocity amplitude soliton remain unchanged interaction except phase shift
resource allocation associated deadlock prevention problem originated design implementation operating systems comprising distributed computing parallel computing grid computing paper presents improving deadlock prevention algorithm used schedule policies resource supply resource allocation heterogeneous distributed platform current scenario deadlock prevention algorithm using two way search method created problem taking higher time complexity root arc traversal edge added graph paper proposes algorithms allocating multiple resources competing services running virtual machines heterogeneous distributed platform implemented performed algorithm proposed using cloudsim simulator experiments results show algorithm quickly prevent deadlock resolve situation approximately orders magnitude practical cases
esl examination instead toefl ielts apply american universities increasingly sought majority learners test paper generating system esl examination designed paper help teachers free onerous task generating test paper efficiency quality test paper generating system depends algorithm design therefore algorithm design must started firstly including establishment mathematical model objective function generating test paper basis steps genetic algorithm coding selection crossover mutation etc elaborating implementation process test paper generating algorithm finally according previous design carried entire process design test paper generating system test paper generating system based genetic algorithm reduces workload teachers proceducing papers reasonable efficient good performance practicality
paper discusses luxury dress luxurious spaces perspective aristocratic court society modern bourgeois society often defines morally condemns luxury conspicuous wasteful consumption beyond essential aristocratic court society feudal period regarded luxury crucial sign fundamental tool social status political ambitions wedding celebrations held dresden court occasion augustus strong marrying son heir also called frederick augustus archduchess maria josepha fitting example understanding luxury
fedorak switzer bridges canadian digestive health foundation public impact series celiac disease canada incidence prevalence direct indirect economic impact gastroenterol canadian digestive health foundation initiated scientific program assess incidence prevalence mortality economic impact digestive disorders across canada current article presents updated findings study concerning celiac disease
advances knowledge acromegaly leading increase survival rate acromegalic subjects study conducted evaluate balance control risk falls peripheral muscle function acromegalic older adults seventeen older subjects acromegaly years paired control subjects evaluated balance scales force platform knee isokinetic dynamometry tests significant differences groups several balance gait scales worse performance greater risk falls acromegalic older adults acromegalic older adults lower values peak torque maximum repetition total work total work extension degrees acromegalic older adults higher values medial lateral range acromegaly subjects lateral instability compromises body balance increases risk falls moreover propensity muscle fatigue individuals
psychoanalytic movement difficulty overcoming malaise bequeathed freud wanted call death drive term remains doubly problematic first indispensable antagonist eros binding reduced particular drive secondly anteros plays vital role subjectivization freudian idea death drive addition drawback confusing dissociative thrust unbinding aggressive component libidinal cathexis precisely lack articulation leads deconstructing constantly observed psychic register aggression much fixing unbinding essential role anteros unbinding process subjectivization illustrated several key operations subjective development sublimatory activity renunciation pleasure discharge work mourning opposed melancholic fixation intricating unbinding parental function finally psychoanalytic treatment work analysis means cease anathematize dynamic component unbinding death seek explain concept subjectivization better
high performance electric motor designs ferrite magnets recently gained interest due high volatile price rare earth magnets however due relatively poor coercivity ferrite magnets designs highly susceptible demagnetization result accurate modelling better understanding phenomenon particularly important paper impact motor stack length level magnetic saturation demagnetization risk studied based dimensional finite element simulations proposed lumped circuit model shown reducing stack length significantly enhance demagnetization resistance effect pronounced designs higher level magnetic saturation benchmark practicality concept previously presented high performance ferrite based design modified using weaker grade ferrite magnet whilst shortening stack length shown demagnetization withstand capability design significantly enhanced exceeded short circuit requirement good safety margin theoretical findings supported prototype testing
introduction oral contraceptives effective birth control good cycle control tolerability however hormonal components could modify mood libido aim aim study evaluate genital vascular effects sexual behavior containing ethinyl estradiol drospirenone comparison flexible combined contraceptive vaginal ring methods forty women underwent sonographic assessment clitoral anatomy vascularization administered mccoy female sexuality questionnaire mfsq beck depression inventory questionnaire bdi estradiol androstenedione testosterone shbg assayed free androgen index fai free estrogen index fei calculated patients randomly submitted group vaginal ring group main outcome measures ultrasonographic clitoral volume pulsatility index dorsal clitoral arteries mfsq bdi hormonal biochemical assays analyzed results therapy testosterone levels reduced groups whereas estradiol decreased group women shbg increased subjects fai fei decreased clitoral volume decreased women dorsal clitoral artery increased patients hormonal contraception associated studied groups significant decrease two factor italian mfsq score marked users group subjects reduction number intercourse week reduction orgasm frequency intercourse pain intercourse worsened use vaginal ring users reported vaginal wetness conclusions six month treatment hormonal contraception associated diminished mfsq score however frequency sexual intercourse orgasm reduced use use associated increased pain intercourse
introduction regulation catalytic activity various phospholipase enzymes high importance enzymes involved various pathological conditions arthritis cardiovascular diseases neurological diseases cancer thus great effort devoted developing synthetic inhibitors new agents treat inflammatory diseases reached clinical trials areas covered review article discusses phospholipase inhibitors presented patent literature october june activities vitro vivo well results clinical trials using synthetic pla inhibitors expert opinion none inhibitors studied clinical trials reached market yet failure lipoprotein associated pla inhibitor darapladib reduce risk major coronary events suggests enzyme may biomarker vascular inflammation rather causal pathway cardiovascular diseases findings together failure secreted pla inhibitor varespladib treatment cardiovascular disease indicate deeper knowledge enzymes needed inhibitors cytosolic pla clinical trials psoriasis atopic dermatitis
paper describes reinforcing effects multiple layers geocell combination rubber soil mixture layers sand compares behaviour multilayered geocell reinforcement alone using plate loading diameter plate load tests performed outdoor test pit dug natural ground measuring plan depth geocell used tests non perforated pocket size height fabricated continuous polypropylene filaments nonwoven geotextile optimum embedded depth first layer geocell vertical spacing geocell layers found approximately times footing diameter optimum percentage rubber replacement found around weight soil mixture bearing capacity increase settlement reduction highest multiple layers geocell rubber reinforcement used results show reinforcements efficiency decreased number reinforcement layers increased particularly low settlement ratios higher bearing capacity lower settlement achieved replacing layers beneath geocell layers rubber soil mixture ratio settlement plate diameter values bearing pressure ratio respectively unreinforced installation installation three layers geocell installation three layers geocell rubber soil layers inclusion geocell layers reduces vertical stress transferred foundation bed distributing load wider area example pressure kpa applied soil surface transferred pressure depth reinforced bed one two three layers geocell respectively compared stress unreinforced bed furthermore use combination geocell rubber soil mixture layers effective use geocell layers reducing stress transferred downwards example beneath soil surface carries stress kpa vertical stress less two geocell layers combined two rubber soil mixture layers two geocell layers
countries implementing policies develop greener energy markets worldwide europe energy climate package asks reductions green house gases renewable sources integration energy efficiency targets polluting intensity electricity may different average considering market inefficiencies particular losses therefore implemented policy must take differences account precisely herein study importance terms emissions extra amount energy necessary cover losses purpose use spanish market system data hourly frequency results show indeed electricity losses significantly explain emissions higher emissions rate covering losses average rate system additionally find market closing technologies used cover losses positive significant impact emissions polluting technologies coal combined cycle close market impact losses emissions high compared rest technologies combined heat power renewables hydropower light results make policy recommendations reduce impact losses emissions
context malnutrition highly prevalent cancer patients important predictor morbidity mortality treatment response toxicity taste smell changes tscs common may contribute malnutrition research previously focused patients receiving chemotherapy head neck radiotherapy however tscs may occur pre treatment treatment modalities cancer survivors review evaluates objective subjective assessment taste smell discusses prevalence tscs cancer reviews clinical sequelae tscs cancer patients objectives critically evaluate objective subjective assessment tscs prevalence clinical sequelae tscs cancer methods literature search conducted using pubmed cinahl embase english language articles published january june search terms included combinations following chemosensory taste smell cancer chemotherapy radiotherapy hormone therapy immunotherapy survivors reference lists articles retrieved also reviewed results variation objective subjective assessment methodologies resulted difficulties interpreting literature tsc prevalence varies depending stage disease treatment regimens respectively tscs patients treatment naive receiving hormone immunotherapy treatment posttreatment cancer survivors adequately studied tscs associated impaired nutritional status relationship cancer associated symptoms nutritional status clearly defined conclusion gold standard assessment tool tscs heterogeneity study methods hinders conclusive identification appropriate way measure tscs subjective measures may reflect patient experience reliably predict changes dietary behaviour evaluation tscs form part nutritional assessments cancer patients true prevalence severity tscs stages cancer could established
purpose blended web based intervention ehealth module embedded collaborative occupational health care eco aimed return work developed found effective sick listed employees common mental disorders order establish feasibility eco process evaluation conducted methods seven process components investigated recruitment reach dose delivered dose received fidelity satisfaction context quantitative qualitative methods used collect data online questionnaire employees website data telephonic interviews occupational physicians ops observations researchers results recruitment uncomplicated employees required several steps ops reach level employee level dose delivered received ops received minimally one email message dose delivered received employees finishing different modules eco varied fidelity support employee eco lower anticipated satisfaction employees ops satisfied intervention however employees reported need support eco context showed ops limited time support employees impossible employee contact outside regular contacts conclusion feasibility eco satisfaction employees ops eco good fidelity ops limited implementation occupational health setting especially contextual barriers regarding time limitation accessibility ops employees addressed
paper needs trusted iot application identified methodology proposed create framework iotee rapid prototyping secure trusted commercial iot applications absence hardware done analysis requirements sample trusted iot application heartbeat sensor hbs classification bhs services decomposition trusted non trusted components furthermore methodology includes algorithm design services like registration authentication authorization secure communication proposed framework detailed operation sequence algorithms also depicted understand overall switching scenario trusted non trusted components application finally dynamic deployment structure created enable disable trusted components framework
based administrative register data norway examine impact hours daylight sick leave absences among workers preferred estimates imply additional hour daylight increases daily entry rate absenteeism percent corresponding recovery rate percent ceteris paribus overall relationship absenteeism daylight hours negative absenteeism also sensitive weather conditions heavy snowfall raises incidence absence winter warm weather reduces probability returning work summer elsevier rights reserved
accelerated formation fibrin clots tumor microenvironment used targeted delivery interferon gamma ifn gamma tumor cells selected cysteine arginine glutamic acid lysine alanine creka fibrin clot binding peptide designed types fusion proteins tumor targeting creka peptide fused ifn gamma terminus without matrix metalloproteinase mmp cleavable linker ifn gamma mmp creka ifn gamma creka respectively former designed release ifn gamma ifn gamma mmp creka bound fibrin clots ensure ifn gamma function tumor milieu ifn gamma activated sequence dependent reporter gene expression cells revealed biological activities ifng creka ifn gamma comparable whereas ifn gamma mmp creka approximately ifng plasma concentrations ifn gamma creka ifn gamma mmp creka remained effective levels least weeks gene transfer mice gene transfer tumor bearing mice intratumoral concentration ifn gamma pcpg ifn gamma mmp creka group tended higher groups inhibition colon tumor growth significantly gene transfer ifn gamma mmp creka ifng ifn gamma creka results indicate targeted delivery ifn gamma fibrin clots ifn gamma mmp creka fusion enhance therapeutic efficacy ifn gamma cancer gene therapy american pharmacists association published elsevier inc rights reserved
background several research areas including medical education focus empathy important topic interpersonal relationships focus central use communication skills related empathy even crucial provide information way makes patients feel involved treatment process psychoanalysis provides initial concept empathy based affective aspects including findings neuroscience brain research enhancing cooperation help integrate aspects empathy longitudinal training program discussion condition psychoanalytic empathy definitions understanding unconscious processes important primarily attend especially dominant affects towards patient interpreting behaviour since explaining emerging affects analyst empathize patient understand unconscious reasons behaviour strong consideration nonverbal communication clinical perceptions intuitive interaction contagion like processes implementation empowerment medical therapeutic curricula one way beneficially using interdisciplinary approaches yield empathy clinical interaction conclusion established methods like training containment reflective functioning affective holding giving meaningful interpretations accordance countertransferential transferential aspects may help put focus clinican patient interaction preservation physicians mental health consequence discussion various training methods take theoretical practical concepts empathy account aim implementation named methods medical curricula
biocathode microbial fuel cells mfcs shown useful reductively changing iii related precipitates surface electrochemically active bacteria eab occurrence intracellular reduction eab still unclear based four eab isolated reduced biocathode mfcs tentatively assigned stenotrophomonas stenotrophomonas maltophilia serratia marcescens achromobacterxylosoxidans naphthalimide rhodamine based iii fluorescent probe used first time sense intracellular iii ions inevitably transiently formed reduction eab reduced mfc biocathodes resulting intracellular accumulation total chromium composite iii ions forms chromium complex open circuit controls intracellular total chromium ranged iii ions forms study illustrates cathode directed intracellular reduction eab gives alternative approach developing imaging functionally sensing iii ions mfc biocathodes elsevier rights reserved
paper proposes two mathematical models photo voltaic cellthe complete model simplified modelwhich used also modeling module string environmental condition based well known five parameters model approach allows write new descriptive equation whose terms functions information always available modern datasheet module manufacturer implies pre processing datasheet parameters needed use proposed model whichever solar irradiance cell module temperature moreover models interpreted circuital point view providing electrical circuits constituted basic electrical components particularly order take account variability environment parameters several variable resistors voltage controlled sources used proposed models tested datasheet parameters commercial modules
better understand solidification large ingot superalloy remelting processes controlled directional solidification experiments conducted examine effect solidification time microstructural evolution alloy cylinders diameter directionally solidified rates ranging min min casting sectioned characterized correlations developed relating microstructural features solidification time results indicate alloy solidification time increases dendrite arms spacing laves carbide size also increases exponent solidification time correlation ranges higher earlier estimates developing thorough experimental technique correlations observed microstructural features ingot casting parameters key generating solidification defect maps data vital integrated computational materials engineering icme efforts determining theoretical limits processing parameter used superalloy remelting using process models
aim present paper study virtual steady state vibrations neighbourhood resonance conditions rotor six degrees freedom linear homogeneous elasto viscous field unstable frequencies zones determined limited power electric motor linear characteristic one time constant bogoliubov mitropolsky asymptotical method applied neighbourhood single basic resonance small difference natural driving frequencies influence motor time constant analyzed value unstable frequency zones quasi steady state increasing decreasing frequencies jump phenomenon special condition increasing driving frequency growing rate could seen right resonance due transfer small angular coordinates main rotation experimental result applied
novel frequency compensation technique named regular miller plus reversed indirect compensation rmric presented paper fast settling three stage amplifiers rmric topology includes one hand miller capacitor combined one nulling resistor connected first stage third stage hand indirect compensation capacitor series resistor added first second stage improves remarkably performance gain bandwidth product gbw sensitivity proposed amplifier detailed design considerations carried demonstrate stability compensation technique circuit simulation results show amplifier driving load capacitance achieves ghz gbw dissipating supply voltage using tsmc cmos technology shows significant improvement figure merits implemented amplifier reaches settling time accuracy
paper aimed employing analytical target cascading atc solve distributed production planning problem atc hierarchy setting parent element core enterprise child element manufacturer core enterprise negotiate plans manufactures individual manufactures able make production plans autonomously finally achieve global objective coordination core enterprise atc offers independent decision making ability member decentralize coordination strategy core enterprise parallel computing method planning model order obtain concrete production quantities balance costs service levels multi objective integer linear programming also introduced model different costs different weights setting different weights different optimization objectives core enterprise obtain lowest overall cost best service quantity meanwhile strategic point view two coordination patterns competitive cooperative modifying iterative mode atc addressed competitive pattern make core enterprise achieve lower cost cooperative pattern make core enterprise maintain better relationship manufactures series comparative analyses conducted identify strengths atc method demonstrate effectiveness proposed coordination patterns particular one experiments considers quantity discount done verify effectiveness atc based coordination mechanism encountering newly added decision making factors
paper reports effectiveness proposed expanded polystyrene eps geofoam cellular reinforcement fly ash filling material overlying soft clay bed small scale laboratory model tests test beds subjected uniformly distributed load means rigid steel plate loads corresponding settlement measured testing eps geofoam cellular reinforcement densities prepared form mattress three different heights effects density eps geofoam height cellular reinforcement planar jute geotextile layer base cellular reinforcement tested series tests systematically study overall performance system terms load carrying capacity settlement behavior test results indicated provision eps geofoam cellular reinforcement fly ash bed significantly improved load carrying capacity clay bed load carrying capacity decreased increasing density eps geofoam increased increase height cellular reinforcement layer jute geotextile placed base cellular reinforcement enhanced load carrying capacity less height cellular reinforcement however effect planer reinforcement decreased increase height cellular reinforcement
prion diseases neurodegenerative pathologies characterized accumulation protease resistant form cellular prion protein named prion protein scrapie prpsc brain prpsc accumulation endoplasmic reticulum result dysregulated calcium homeostasis subsequent initiation unfolded protein response upr leading neuronal dysfunction apoptosis molecular mechanisms transition adaptation stress stress induced apoptosis still unclear mitogen activated protein kinases mapks serine threonine protein kinases rule signaling many extracellular stimuli plasma membrane nucleus however identification numerous points cross talk upr mapk signaling pathways may contribute understanding consequences stress prion diseases indeed mapk signaling network known regulate cell cycle progression cell survival death responses following variety stresses including misfolded protein response stress article review upr signaling prion diseases discuss triad mapk signaling pathways also describe role played mapk signaling cascades alzheimer parkinson disease also overview mechanisms cell death role mapk signaling prion disease progression highlight potential avenues therapeutic intervention
variation temperature primary environmental factor affects behavior structures therefore understanding mechanisms normal temperature induced variations structural behavior would help distinguishing anomalies study used structural health monitoring data shanghai yangtze river bridge steel girder cable stayed bridge investigate mechanisms thermally induced vertical deflection mid span bridges results multisource combination thermal expansion effects cable temperature cab girder temperature gir girder differential temperature dif tower temperature tow could approximated multiple linear superpositions operational conditions sensitivities shanghai yangtze river bridge temperatures following order cab gir tow dif however direction effect tcab observed opposite three temperatures magnitudes effects tcab tgir found almost one order greater dif tow mechanisms thermally induced vertical deflection variation mid span cable stayed bridge well analytical methodology adopted study could applicable long span cable stayed bridges
detection data structures spectral clustering approaches becomes difficult task dealing complex distributions moreover need real user prior knowledge influence free parameters building graph introduce graph pruning approach termed kernel alignment based graph pruning kagp within spectral clustering framework enhances local global data consistencies given input similarity kagp allows revealing hidden data structures finding relevant pair wise relationships among samples kagp estimates loss information pruning process terms kernel alignment based cost function besides encode sample similarities using compactly supported kernel function allows obtaining sparse data representation support spectral clustering techniques attained results shows kagp enhances clustering performance cases addition kagp avoids need comprehensive user knowledge regarding influence free parameters elsevier rights reserved
complex reluctance bridges electromagnetic devices shown able detect angle strain steel changes magnitude applied strain sensitivity evidence presented also detect magnitude residual strain research suggested area residual strain detection technique simple use easy understand two new terms introduced complex reluctance circuits impermance parallel impedance alternating current electrical circuits reductance parallel reactance alternating current electrical circuits
several years since scientists poland use resources distributed computing infrastructure plgrid flexible large scale infrastructure offers homogeneous easy use access organizationally distributed heterogeneous hardware software resources built accordance good organizational engineering practices taking advantage international experience field since scientists need assistance close collaboration service providers infrastructure relied users requirements needs coming different scientific disciplines equipped specific environments solutions services suitable various disciplines tools help lowering barriers hinder researchers use infrastructure
paper two two party quantum key agreement protocols proposed logical chi states logical bell states two protocols immune collective dephasing noise collective rotation noise respectively make full use measurement correlation property multi particle entangled states delayed measurement technique ensures two participants exchange secret keys fairly establishes shared key information leakage problem establishing shared key use delayed measurement technique decoy state technology makes two protocols resist participant outsider attacks furthermore two protocols congenitally free trojan horse attacks high qubit efficiency
students autism likely bullied typically developing peers however several studies shown likelihood bullied increases context exposure certain risk factors behaviour difficulties poor peer relationships study explores vulnerability bullying cumulative risk perspective number risks rather nature considered total teachers parents young people autism spectrum conditions participated study established risk factors summed form cumulative risk score teacher parent models evidence cumulative risk effect models suggesting number risks increased exposure bullying quadratic effect found teacher model indicating disproportionate increase likelihood bullied relation number risk factors young person exposed light findings proposed attention needs given number risks children young people autism spectrum conditions exposed planning interventions providing suitable educational environment
regarding effect third person perception censorship attitudes present study first highlighted logical weaknesses previously proposed rationales limitations previously used statistical models test effect study reanalyzed data past research effect third person perception study average effects self perceptual gap media influence censorship attitudes estimated based reports previous studies total study reanalyzed schmierbach boyle mcleod correlational data results two studies showed presumed effect others stronger predictor censorship attitudes self differential perceived media effect
assess differences patient reported catheter specific satisfaction quality life either suprapubic transurethral postoperative bladder drainage following reconstructive pelvic surgery prospective study eligible women scheduled undergo reconstructive surgery requiring bladder drainage study period november march women undergo planned procedure require bladder drainage excluded primary outcome patient reported quality life using catheter specific instruments including catheter related quality life ciqol instrument modified version intermittent self catheterization questionnaire isc designed evaluate aspects catheter related quality life satisfaction specific needs individual total women analyzed transurethral catheter group suprapubic group women suprapubic bladder drainage higher quality life satisfaction scores women transurethral bladder drainage measured isc mean difference difference quality life ciqol regression analysis women suprapubic bladder drainage satisfied catheter specific needs despite longer duration catheter use concurrent continence surgery higher trait anxiety differences catheter specific quality life patient satisfaction scores favoring suprapubic bladder drainage support continued use appropriately selected women treatment temporary postoperative urinary retention reconstructive pelvic surgery
meet ever increasing load demand sustainable way reinforcement photovoltaic array wind turbine capacitor bank distribution network proposed paper comprehensive planning model presented determine location required installation capacity multiple array capacitor units electric power distribution network heavy load growth situation intermittent power generation renewable energy sources ress quantified suitable probability distribution functions incorporated planning model planning approach considers several welfare areas distribution systems viz increment profit margin reduction carbon oxide emission minimization distribution power losses enhancement voltage stability level improvement network security considering power flow voltage limit line capacity res penetration capacitor penetration utility economy constraint non dominated sorting based multi objective particle swarm optimization algorithm along fuzzy decision making criteria used find best allocation alternative mix res capacitor planning problem effectiveness proposed model tested typical bus indian rural distribution network results show efficient techno eco environmental optimization obtained combined res capacitor planning model elsevier ltd rights reserved
background krokodil crocodile illegal homemade desomorphine drug obtained chemical reactions commercial codeine drugs several powerful highly toxic chemical agents increasing addiction hallucinogenic effects compared morphine analogues methods paper summarizes complete review old drug called desomorphine krokodil presenting chemistry pharmacology metabolism toxicology analysis results particular interest concern cheaper injectable semisynthetic opioid drug largely used recent years recreational purposes several eastern european well north south american countries despite known damage health continuous use might induce injuries much stronger aggressive morphine infecting rotting skin soft tissue bone addicts point injection less three years cases evolves death basis imperative literature reviews focus chemistry pharmacology toxicology analysis dangerous krokodil find strategies rapid effective determination mitigate adverse effects addicts prevent consumption conclusions crucial know symptoms consequences use krokodil well methods identification quantification desomorphine contaminants metabolites help forensic work diagnosis propose actions control eradicate great danger public health around world elsevier rights reserved
enzymatic treatments textile remarkable environmentally friendly properties less energy water chemical need low waste water pollution paper combined use amylase pectinase cellulase bath studied different parts first part experiment raw cotton woven fabrics treated amylase pectinase cellulase enzymes bath different process conditions desize scour polish results showed one bath triple enzymatic mixture process could done successfully therefore could used instead conventional processes moreover enzymatic process completed almost half conventional treatments durations temperatures second part effects enzymes dosages analyzed using enzymes pairwise combinations way effects amount enzymes also effects enzyme fabric property seen distinctly increases enzymes concentrations led increase every tested value except tear strength pectinase cellulase combination resulted minimum tear strength whiteness maximum absorbency usage enzymes one one constituted final part study found amylase affected whiteness absorbency cellulase affected tear strength particularly although combined enzymatic treatments conducted moderate conditions conventional processes comparable results observed
introduction gingival overgrowth known side effect calcium channel blockers particularly nifedipine usually presents diffuse overgrowth unusual presentation amlodipine induced gingival overgrowth presented large erythematous gingival mass prominent feature rapid almost complete resolution mass reduction amlodipine dosage case presentation boy aged years presented gingival mass first noticed week previously associated discomfort bleeding medical history significant wiskott aldrich syndrome bone marrow transplant years previously subsequent development severe chronic graft versus host disease hismedication included amlodipine enalapril tacrolimus sulfamethoxazole trimethoprim voriconazole hydrocortisone cream intravenous immunoglobulin infusions allergies included vancomycin metoclopramide clonidine latex examination revealed mild generalized gingival overgrowth presence large erythematous sessile soft non tender mass mandibular right gingiva primary lateral incisor canine resembling pyogenic granuloma suppuration bleeding probing radiographic abnormalities noted recommendation made physician patient replace amlodipine different class antihypertensive response amlodipine dosage decreased daily week follow visit considerable reduction size gingival mass occurred shortly complete resolution reported parents intervention scaling excision performed conclusion discontinuation reduction amlodipine dose daily prior surgical intervention considered patients taking amlodipine presenting gingival mass
article develops taxonomy memory errors terms three conditions accuracy memory representation reliability memory process internality respect remembering subject process unlike previous taxonomies appeal retention information rather reliability internality taxonomy accommodate misremembering drm effect falsidical confabulation veridical relearning also veridical confabulation falsidical relearning moreover assume successful remembering presupposes retention information taxonomy compatible recent simulation theories remembering
recurrent respiratory infections rri represent widespread condition severe social economic impact immunostimulants used prevention crucial better characterize children rri refine diagnosis identify effective personalized prevention strategies metabolomics high dimensional biological method used hypothesis free biomarker profiling examining large number metabolites given sample using spectroscopic techniques multivariate statistical data analysis enables infer metabolic information relevant biological characterization given physiological pathological condition lead emergence new sometimes unexpected metabolites hitherto unknown metabolic pathways enabling formulation new pathogenetic hypotheses identification new therapeutic targets aim pilot study apply mass spectrometry based metabolomics analysis urine samples children rri comparing children biochemical metabolic profiles healthy peers also compared rri children healthy controls metabolomic urinary profiles former received pidotimod treatment months see whether immunostimulant associated biochemical changes rri children metabolic profile children age range yeas rri matched per age healthy peers history respiratory diseases allergies enrolled metabolomic urine samples compared rri children treated pidotimod period months metabolomic analyses urine samples done using mass spectrometry combined ultra performance liquid chromatography uplc resulting spectroscopic data underwent multivariate statistical analysis relevant variables characterizing two groups identified data modeling post transformation pls discriminant analysis ptpls generated robust model capable discriminating urine samples children rri healthy controls fold value dataset included time per mass variables characterized difference two groups thirty five distinctive variables persisted profiles children rri pidotimod treatment metabolomics discriminate children rri healthy controls suggesting former dysregulated metabolic profile among variables characterizing children rri metabolites may reflect presence different microbiome pidotimod treatment metabolic profile children rri longer different healthy controls except persistence microbiome related variables surmise pidotimod partially restores altered metabolic profile children rri without modifying metabolites related composition gut microbiota light results hypothesize potential synergic effect combined use immunostimulants probiotics purpose prevention children rri elsevier ltd rights reserved
brief robust shrinkage normalized sign rshns algorithm presented uses optimal step size minimizing energy noise free posteriori error signal using price theorem reduce impact impulsive noise noise free error signal estimated using robust shrinkage method uses two threshold parameters compared conventional shrinkage method finally improved convergence performance proposed rshns algorithm demonstrated simulation results system identification echo cancellation applications
bright light therapy broader realm chronotherapy remain underappreciated underutilized despite empirical support efficacy extends beyond seasonal affective disorder includes nonseasonal depression sleep disorders emerging evidence role treating attention deficit hyperactivity disorder delirium dementia practical overview offered including key aspects underlying biology indications treatment parameters treatment adverse effects transformation relationship light darkness contemporary life
previous work demonstrated characteristic changes could occur anterior wrist medial malleolus electric deaths hand foot electric circuit pathway electric shock rat model however whether phenomenon occurs humans unknown aim present retrospective study ascertain whether anterior wrist medial malleolus could also selected promising significant sites electric death hand foot circuit pathway nineteen human cases autopsy one clinical survivor sustained severe electric shock hand foot circuit pathway analyzed additional ten autopsy patients died traffic accidents sudden cardiac attacks used control group histopathological changes soft tissues anterior wrist medial malleolus autopsy patients well electric current pathway survivor observed results showed nuclear polarizations anterior wrist medial malleolus soft tissues electric death extremely noticeable compared controls severe electrical injury survivor occurred anterior wrist findings suggest soft tissues anterior wrist medial malleolus narrowest parts limbs could used complementary sites tissue selection considered necessary locations examinations assess electric death medicolegal identification
introduction evaluated performance muscle perfusion scan mps assess muscle perfusion reserve mpr prediction incident diabetic foot ulcerations dfu methods recruited diabetic patients without history dfu five mci mibi injected intravenously repetitive dorsal plantar right foot flexions posterior calves imaged counts region interests roi right left calves collected mpr calculated percentage counts right calf roi counts left calf roi counts left calf roi six patients complete study due technical errors patients followed possible occurrence dfu least months results range days follow period patients developed dfu mpr insignificantly lower patients developed foot ulceration comparison without foot ulceration cutoff first decile mpr values discriminated patients without future dfu accuracy value conclusion mps useful detect patients diabetes risk future dfu
word clouds popular method visualize frequency words textual data nowadays many text based data sets flickr tags geo referenced important spatial component however existing automated methods generate word clouds unable incorporate spatial information introduce geo word clouds word clouds capture frequency also spatial relevance words input set locations one geographic regions possibly several text labels per location aggregate word frequencies according point clusters employ greedy strategy place appropriately sized labels without overlap close possible corresponding locations draw spatial shapes geographic regions corresponding labels experimentally explore trade offs concerning location labels relative sizes number spatial clusters resulting word clouds visually pleasing low error terms relative scaling locational accuracy words using small number clusters per label
transnational trade seedless kishu mandarins citrus kinokuni mukakukishu would require subjected suitable phytosanitary treatment irradiation used effective treatment many fruit effect quality kishu mandarins unknown seedless kishu mandarins treated gamma irradiation stored three weeks degrees one week degrees irradiation promoted browning calyx end fungal infection irradiation caused immediate reductions pulp firmness vitamin individual sugars carotenoids increased content organic acids except ascorbic acid phenolic compounds volatile profile tested fruit also differentially altered irradiation initial changes dose dependent seedless kishu mandarins significantly sensitive irradiation suitable treatment studied doses elsevier ltd rights reserved
social cognition deficits described patients schizophrenia borderline personality disorder bpd however former tend towards simplistic mental state attributions undermentalizing latter likely make overly complex mental state inferences overmentalizing performance complex tasks shown correlate neurocognitive ability emotion perception history trauma overconfidence errors however unclear factors relate different aspects deficits aim present study examine pathways impairment investigating performance profiles predictors comparatively bpd schizophrenia participants patients bpd patients schizophrenia healthy controls undermentalizing overmentalizing assessed ecologically valid task patients bpd exhibited increased overmentalizing whereas patients schizophrenia showed extensive deficit pattern main error type undermentalizing overconfidence errors important predictor overmentalizing undermentalizing depended mainly verbal memory emotion perception thus bpd und schizophrenia exhibited different impairment patterns different types errors predicted different factors findings implications optimization treatment approaches elsevier ireland ltd rights reserved
gaming addiction usually characterized loss control mental instability may particularly problematic military task performance often requires optimal physical mental functioning previous studies thus far investigated levels gaming addiction among conscripts aim present study assess levels gaming addiction among conscripts entry service investigate indicators lower psychosocial well particularly boredom loneliness depression anxiety help explain variance gaming addiction among conscripts lower psychosocial well previously related gaming addiction general population coping negative emotions also identified major motivation gaming sample consisted conscripts men mean age years results showed conscripts addicted gaming addicted gamers scored significantly higher boredom loneliness depression anxiety compared nonproblem gamers nongamers results hierarchical regression analyses showed weekly time spent gaming explained variance gaming addiction whereas indicators low psychosocial well explained additional step depression loneliness lack external stimulation contributed significantly addiction likely negative impact training operative ability task performance soldiers hence revision present selection criteria include gaming addiction exclusion criterion drafting may warranted
amyloid beta peptide beta considered key predictor preclinical diagnosis alzheimer disease whose diagnosis still hampered lack early sensitive convenient tools herein propose colorimetric sandwich immunosensor beta based dual antibody modified gold nanoparticles bare aunps successfully coated terminal antibody beta aunp terminal antibody beta aunp respectively subsequently beta simultaneously captured prepared aunps aunp aunp owing specific binding terminal antibody beta thus aunps nab aggregated accompanying obvious color change red blue means colorimetric sandwich immunosensor system good linearity within range found detection limit equal better reported detection methods beta newly colorimetric sandwich immunosensor system strikingly achieves specific visual simply detection ail exploited toward determination similar biomarkers related diseases biological biomedical diagnosis published elsevier
introduction study aimed determine relationship patients presenting pediatric emergency department ped potential tobacco smoke exposure tse related illnesses methods retrospective review electronic medical records pediatric emergency department patients conducted sociodemographic characteristics tse related illnesses tse documentation extracted logistic regression analyses performed results one fifth patients tserelated illnesses patients younger male non white hispanic medicaid medicare insurance low triage acuity admitted non intensive care unit intensive care unit significantly likely tse related illnesses twenty eight percent patients tse documentation positive tse status although regression models positive tse indicated similar findings difference found based ethnicity discussion pediatric emergency departments especially care large numbers children offer tobacco interventions target risk populations caregivers likely receiving interventions health care settings
study aimed determine changes sodium nitrate sodium nitrite nitrosodiethylamine ndea vitro human digestion effect enterobacteria changes compounds concentrations nitrate nitrite ndea significantly reduced ppm ppm respectively vitro human digestion enterobacteria escherichia coli lactobacillus casei reduced amount compounds present vitro human digestion study first report coli dramatically reduce amount nitrite vitro human digestion may due effect nitrite reductase present coli therefore conclude amounts potentially harmful substances toxicity decreased human digestion elsevier ltd rights reserved
plantar warts caused human papillomaviruses hpvs associated several hpv genotypes however studies focused exclusively plantar warts work aim identify hpv genotypes plantar warts explore relation demographic clinical characteristics patients total patients diagnosed plantar warts recruited laser unit podiatric hospital university barcelona spain inner hyperkeratosis laminar sections warts collected dna samples extracted amplification conserved region hpv gene performed polymerase chain reaction method dna amplicons sequenced hpv types identified prevalent genotypes detected among analyzed plantar warts hpv hpv hpv hpv hpv majority patients presented one single plantar wart whereas multiple warts detected patients one patient multiple warts presented hpv types two different genera suggesting spread warts selfinoculation well novo infection significant differences number warts toes midfoot heel found prevalent hpv types detected areas belonged alpha genus work provides new insight plantar warts associated hpv genotypes evidences usefulness reliability sample collection procedure pcr method used hpv detection typing wiley periodicals inc
due lack effective longitudinal constraint center tower structural stiffness three tower suspension bridge becomes less two tower suspension bridge therefore becomes susceptible seismic action taking three tower suspension bridge taizhou highway bridge yangtze river two main spans example structural dynamic characteristics seismic performance bridge investigated effects cable sag span ratio structural stiffness center tower longitudinal constraint girder seismic response bridge also investigated favorable structural system discussed respect seismic performance results show structural response lateral seismic action remarkable especially side towers therefore attentions paid lateral seismic performance also side towers large cable sag flexible center tower longitudinal elastic cable center tower girder favorable improve structural seismic performance long span three tower suspension bridges
mobile operating system framework android plays significant role supporting mobile apps however current android application model efficient using current two common approaches including activity xml layout files axlf html webkit hwk models paper propose novel middleware service solution overcomes drawbacks using pre cache approach precache technology android system patas proposed method uses html design application interface separately store page framework page data create new middleware web pages version flags indicate whether expired experimental results represent proposed approach improve execution efficiency well reduce networking costs broadly used cloud based distributed systems elsevier rights reserved
reproductive coercion involves behavior interferes contraceptive pregnancy choices women occasionally men includes birth control sabotage intentional destruction woman chosen method contraception pregnancy pressure behaviors coerce pregnancy one wishes pregnancy coercion threats direct outcome pregnancy associated serious reproductive consequences including unintended pregnancy abortion sexually transmitted infections poor pregnancy outcomes psychological trauma article presents overview recent literature surrounding reproductive coercion relates reproductive health outcomes women adolescents lesbian gay bisexual transgender community men experience reproductive coercion also discussed clinical implications evidence based strategies assessment intervention identified
hydrochloric acid doped thin film poly methyl aniline pomani mno nanocomposites fabricated glass substrate nanocomposite films showed ntc characteristics temperature range degrees repeatability temperature range degrees cut temperature thermistor fabricated nanocomposite material found degrees synthesised nanocomposite material characterized using xrd tem structure morphology tga dtc thermal stability thermistor constant beta observed characteristics range activation energy delta calculated range linearization thin film based ntc thermistors carried using low cost analog circuit adding parallel series resistance operational amplifier amp observed thin film based temperature sensors repeatable temperature sensing behavior linearization high sensitivity low power dissipation diss elsevier rights reserved
background intermittent theta burst stimulation itbs primary motor cortex improves transiently lower limbs spasticity multiple sclerosis however cerebral mechanisms underlying effect never investigated objective assess whether modulation spasticity induced itbs underlined functional reorganization primary motor cortices methods total patients suffering lower limbs spasticity randomized receive real itbs sham itbs first half week indoor rehabilitation programme spasticity assessed using modified ashworth scale visual analogue scale baseline stimulation session end rehabilitation programme resting state functional magnetic resonance imaging fmri performed three time points brain functional networks topology analysed using graph theoretical approach results end stimulation improvement spasticity greater real itbs group sham itbs group itbs significant effect balance connectivity degree stimulated homologous primary motor cortex changes inter hemispheric balance correlated improvement spasticity rho conclusion longitudinal resting state fmri study evidences functional reorganization primary motor cortices may underlie effect itbs spasticity
linear transformation method proposed handle vector autoregression mixed frequency time series data temporally aggregated observations impose linear constraints distribution latent variables converted observation replaces latent variable full sample transformation yields closed form simulation smoother partial sample transformation leads computationally efficient sampler suitable parallel computing elsevier rights reserved
finite element simulation mixed convection within porous square cavities darcy brinkmanforchheimer model carried present work penalty optimization based galerkin finite element method used solve partial differential equations heat fluid flow bejan heatline concept employed visualize heat flow within closed cavities based motion horizontal wall cases vertical wall cases involving isothermally hot bottom wall cold side walls insulated top wall various fluids prandtl number reynolds number grashof number higher permeability leads enhanced buoyancy convection cases although direction motion wall significantly influences fluid flow field within enclosure due decoupling fluid thermal fields low conductive heat transfer occurs seen end end heatlines also found overall heat transfer rates bottom wall identical cases cases irrespective convection dominant heat transfer occurs cases strong convective circulation cells observed cases plume shaped isotherms also observed along centerline cases multiple convective heatline cells observed cases observed strengths fluid heat circulation cells less compared cases due weak buoyancy force high order achieve high heat transfer rate bottom wall mixed convection involving various moving walls case case vertically moving wall preferred high case case vertically moving wall preferred based maximum heat transfer rate bottom wall published elsevier masson sas
paper deals long term properties thermoelastic nonlinear string beam system related well known lazer mckenna suspension bridge model xxxx beta parallel parallel theta phi theta theta txx phi phi particular mechanical dissipation occurs equations loss energy entirely due thermal effects existence regular global attractors associated solution semigroup proved without resorting bootstrap argument time independent supplies beta element copyright john wiley sons ltd
contact free method obtain current voltage characteristics cvc hard superconductors measuring relaxation magnetization perpendicular magnetic field developed relaxation curves obtained melt textured ybco samples well fitted curves calculated within electrodynamic model using power law cvc procedure uses two fitting parameters namely critical sheet current exponent tit power law cvc elsevier ltd rights reserved
acquiring high quality imagery since launch tri stereo three view three line array imagery become one top choices extracting dsm digital surface model products china past years tri stereo sensors offer users ability capture imagery large regions including entire territory country china resulting large volume tri stereo scenes require timely near real time processing something currently possible using traditional photogrammetry workstations paper presents high performance computing solution efficiently automatically extract dsm products tri stereo imagery high performance computing solution leverages certain parallel computing technologies accelerate computation within individual scene deploys distributed computing technology increase overall data throughput robust efficient manner taking advantage inherent efficiencies within high performance computing environment dsm extraction process exploit combinations offered set tri stereo images forward backword forward nadir backword nadir dsm results merged potential combinations minimize blunders incorrect matches also offer ability remove potential occlusions may exist single stereo pair resulting improved accuracy quality versus merged accelerated performance inherent within individual steps dsm extraction workflow including collection ground control points tie points image bundle adjustment creation epipolar images computing elevations preliminary experiments large area china proven high performance computing system generate high quality accurate dsm products rapid manner
today internet connected world mobile devices increasingly used access cloud storage services allow users access data anywhere anytime mobile devices however known used targeted cyber criminals conduct malicious activities data exfiltration malware identity theft piracy illegal trading sexual harassment cyber stalking cyber terrorism consequently mobile devices increasing important source evidence digital investigations paper examine four popular cloud client apps namely onedrive box googledrive dropbox android ios platforms two popular mobile operating systems identify artefacts forensic interest information generated login uploading downloading deletion sharing files findings may assist forensic examiners practitioners real world examination cloud client applications android ios platforms
objective objective study describe patient experience intravenous biologics ankylosing spondylitis crohn disease psoriatic arthritis psoriasis rheumatoid arthritis ulcerative colitis methods semi structured telephone interviews conducted patients autoimmune diseases receiving biologic treat disease results point scale satisfied satisfied mean satisfaction medication rated patients rated satisfaction frequently perceived benefits therapy related supervision provided health care professionals patients preferred medication subcutaneous injection three common reasons preferring wanting self inject less frequent dosing preference administration health care professional african american black patients stronger preference administration caucasian white patients greater dislike needles self injection hospital outpatient departments rated well physician office infusion half patients reported physician equally influenced choice switch subcutaneous therapy given choice infusion center conclusion users biologics highly satisfied medications perceive opportunity health care provider interaction infusion facilities advantage regimen findings support continued need therapeutic options shared decision making patients physicians selecting biologic treatments
originally shown king altman graph theory specifically use spanning trees provides means solve kinetics catalytic network steady state regime taking input data rate constants herein shown translation rate constants gibbs energies provides simpler way estimate energy span apparent activation energy full reaction determining states turnover frequency tof catalytic networks examining concepts chemical kinetics rigorous mathematical treatment alternative definition suggested term chemical mechanism addition analogy electrical circuits chemical resistor terms called kinestors identified parallel series chemical circuits providing new ohmic interpretation catalysis
study stabilization problem nonlinear multiple time delay large scale systems considered first neural network model employed approximate interconnected subsystem linear differential inclusion ldi state space representation established dynamics model based ldi state space representation robust fuzzy control design proposed overcome effect modeling errors nonlinear multiple time delay large scale systems models next terms lyapunov direct method delay dependent criterion derived order guarantee stability tub nonlinear multiple time delay large scale systems subsequently stability conditions criterion reformulated linear matrix inequalities lmis based lmis decentralized control scheme set fuzzy controllers synthesized stabilize nonlinear large scale system infinity control performance achieved time designed fuzzy controllers stabilize nonlinear large scale system batch dithers auxiliaries fuzzy controllers simultaneously introduced stabilize nonlinear large scale system injection high frequency signals commonly called dithers nonlinear systems may improve performance frequencies dithers high enough outputs dithered large scale system corresponding mathematical model relaxed large scale system made close desired makes possible obtain rigorous prediction stability dithered large scale system establishing relaxed large scale system finally numerical example simulations provided illustrate feasibility approach
previous study demonstrated danshui river almost highest dissolved inorganic nitrogen din yield world exports din form ammonium unlike world large rivers however din sources poorly constrained study contributions major sources taipei metropolitan area din export danshui river investigated observed ammonium major din species downstream reaches resulting ammonium dominated inputs effluents wastewater treatment plants wwtp rain water pumping stations rwps din concentrations downstream urban reaches substantially elevated upstream tributaries annually discharge similar din downstream reaches however din discharge downstream reaches rises similar resulting contribution rwps collected water similar effluents two wwtp similar rwps collected water inherently contains contribution atmospheric deposition similar din finding implies similar similar downstream output din flux danshui river urban runoff attributed human activities taipei metropolitan area improve water quality danshui river water quality controls urban runoff important
introduction atrial fibrillation heart failure often coexist present associated negative outcomes increased hospitalizations mortality blockade effective inf may useful presence bucindolol non selective blocker vasodilatory effect may used area covered review evaluates efficacy safety bucindolol patients largest amount data comes best trial evaluated efficacy bucindolol patients since bucindolol effects genetically modulated adrenergic receptor polymorphisms best genetic substudy arose expert opinion best trial bucindolol demonstrated efficacy patients showing reduction new onset atrial fibrillation events particularly arg arg homozygous genetic study designed determine whether bucindolol therapy superior metoprolol preventing recurrent genetically targeted population patients furthermore drug safe presents side effects blockers showed clear benefits african americans class nyha patients studies needed confirm validate role bucindolol economic implications
benefits cooperative learning known time constructivist approach makes possible significant learning student way use kind learning apply workgroups practices classes aim improve academicals results engineering students line european higher education area ehea work done practice groups subject called strength materials subject taught second course degrees energetic engineering miner energetic resources engineering university vigo matter common degrees fact make groups students heterogeneous different academic profiles experience consists form different workgroup beginning semester groups work along course make different group activities proposed teacher differences composition groups made students degrees groups formed members degree also groups made students made teacher two clear objectives observe interaction students different academic profiles influence works students decide work together groups imposes group members
third party punishment tpp norm violations essential deterrent large scale human societies builds two essential cognitive functions evaluating legal responsibility determining appropriate punishment despite converging evidence tpp mediated specific set brain regions little known effective connectivity direction strength connections applying parametric event related functional mri conjunction multivariate granger causality analysis asked healthy participants estimate much punishment hypothetical perpetrator deserves intentionally committing criminal offenses varying levels harm results confirmed tpp legal decisions based two domain general networks mentalizing network evaluating legal responsibility central executive network determining appropriate punishment temporal pole dorsomedial prefrontal cortex pfc emerged hubs mentalizing network uniquely generating converging output connections ventromedial pfc temporo parietal junction posterior cingulate particular dorsomedial pfc received inputs activation connectivity dorsolateral pfc correlated degree punishment supports hypothesis dorsomedial pfc acts driver tpp activation pattern leading decision appropriate punishment conclusion results advance understanding organizational elements tpp brain networks provide better insights mental states judges jurors tasked blaming punishing legal wrongs
background centers disease control prevention medical eligibility criteria contraceptive use recommends combined hormonal contraceptives birth control pills contraceptive patch vaginal ring avoided women specific medical conditions increased risk cardiovascular events associated estrogen use whether women category theoretical proven risk usually outweigh advantages category unacceptable health risk contraindications appropriately avoiding estrogen containing combined hormonal contraceptives unknown objective describe prevalence combined hormonal contraceptive use among sample reproductive age women medical contraindications estrogen use hypothesis women categories contraindications would use estrogen containing contraception less often women without medical contraindications also explored whether inappropriate estrogen containing contraceptive use related contraceptive provider characteristics study design data baseline survey mynewoptions study included privately insured women residing pennsylvania aged years sexually active intending pregnancy next year women surveyed medical conditions contraceptive use characteristics contraceptive provider women considered contraindication combined hormonal contraceptives reported category category contraindication hypertension smokers older age years history venous thromboembolism diabetes complications coronary artery disease systemic lupus erythematosus anti phospholipid antibodies breast cancer migraine headaches aura tests general association used compare combined hormonal contraceptives use contraceptive health provider characteristics sociodemographic data women without contraindications estrogen use results mynewoptions baseline study sample included adult women mostly young years white employed married cohabiting thirteen percent sample medical contraindication estrogen containing contraceptive use migraine aura common contraindication followed smokers older age years hypertension history venous thromboembolism diabetes complications high use combined hormonal contraceptives reported among women medical contraindications estrogen statistically different women without medical contraindication among women contraindication whether use estrogen containing contraceptive vary education level income weight category respect contraceptive prescribers differences prescriber specialty provider type clinic type comparing women using using estrogen containing contraceptive conclusion among study sample reproductive age women high rate combined hormonal contraceptive use women medical contraindication estrogen use women may increased risk cardiovascular events processes need improved ensure women medical contraindications estrogen containing contraception offered safest effective methods including long acting reversible contraceptives intrauterine devices contraceptive implant
order specify databases completely conceptual level conceptual database specification languages contain data definition sub language ddl specifying data structures constraints data retrieval sub language drl specifying queries well declarative data manipulation sub language dml specifying transactions object role modeling orm powerful method designing querying database models conceptual level means verbalization application also described natural language used domain experts communication validation purposes orm currently comprises ddl drl conquer however orm method yet contain expressive dml specifying transactions conceptual level earlier paper designed syntactic extension orm method dml specifying transactions conceptual level purely declarative way transactions proposed syntaxes verbalizations diagrams however give formal semantics purpose paper add clear formal purely declarative semantics proposed orm transactions paper also formally defines rollbacks illustrates everything examples including solution well known transaction specification problem extension orm expressive set completely declaratively specified transactions makes orm complete database specification method conceptual level elsevier ltd rights reserved
many regions united states deficient mental health services especially rural areas result deficiencies many patients need psychiatric services often left untreated although clear telepsychiatry great potential improving patient access mental health care areas psychiatric services deficient lack familiarity technology inadequate training current barriers expanding use telepsychiatry review telepsychiatry clinical applications evidence based literature regarding competencies graduate medical education related telepsychiatry provided approach implementing telepsychiatry curriculum suggested also propose elective clinical experience resources didactics independent study enable residents develop knowledge base competence practice telepsychiatry
current trends moving toward immediate skin skin care birth newborn shown highly beneficial physiologically emotionally mother baby strategies considerations initiating skin skin care perioperative suite immediately cesarean birth thermoregulation baby operative suite equipment baby family positioning maternal monitoring presented initiating skin skin care soon possible birth recommended
objectives patient centered medical home widely supported strategy delivering high quality primary care objective study examine whether children primary care experiences nationally become aligned medical home model time may varied vulnerable children methods study analyzed data children aged years families responding one three iterations national survey children health year assessed indicators four medical home features access continuity comprehensiveness family centeredness total medical home score children nationally set social demographic risk factors results indicators access continuity total medical home scores fluctuated improved overall point increases respectively indicators comprehensiveness family centered care measures declined point decreases respectively children highest levels social demographic risk experienced larger fluctuations measures time conclusions practice improvements extent children primary care experiences aligned medical home model though linearly component features children risk factors experienced volatile changes suggesting particular need attend primary care experiences vulnerable children
parkinson disease several efforts spent order find biochemical parameters able identify progression pathological processes basis disease already known advanced patients manifesting dyskinesia featured high homovanillic acid hva dopamine ratio suggesting increased turnover patients less clear whether similar changes affect mild moderate stages disease hoehn yahr stage hence tested whether cerebrospinal fluid csf concentrations major metabolites either dihydroxyphenylacetic acid dopac hva correlate motor performance mild moderate patients csf samples collected days anti drugs washout via lumbar puncture performed min following administration oral levodopa dose timing determined light previous tests clarifying oral administration csf concentration reaches plateau respective stage duration dopac hva assayed high performance liquid chromatography group patients distributed two groups basis stage cut patients hva correlated dopac hva dopac csf levels increased parallel motor impairment importantly hva correlated motor impairment measured unified parkinson disease score iii updrs present findings showed early alteration pre synaptic machinery documented progressive increase csf hva concentrations also correlated motor impairment therefore suggest potential use measuring csf hva level possible biomarker stage changes order monitor effectiveness modifying pharmacological therapies elsevier ltd rights reserved
phosphoglycerate mutase pgam catalyzes eighth step glycolysis often found upregulated cancer cells test hypothesis phosphorylation tyrosine residue pgam greatly enhances activity performed conventional steered molecular dynamics simulations binding unbinding pgam substrates tyrosine either phosphorylated analyzed simulated data terms structural stability hydrogen bond formation binding free energy etc found tyrosine phosphorylation enhances binding pgam substrates generating electrostatic environment structural features advantageous binding results may provide valuable insights computer aided design drugs specifically target cancer cells pgam tyrosine phosphorylated
present generalization bode integral formula discrete time linear periodic systems shown similar classical bode integral formula sensitivity integral discrete time linear periodic system depends open loop dynamics system particular open loop characteristic multipliers outside unit circle complex plane integral derived using asymptotic eigenvalue distribution theorem block toeplitz matrices require open loop system stable disturbance gaussian result demonstrated application class multi rate sampled data systems commensurate rates
pervasiveness explicit implicit weight bias defined negative stereotypes prejudice regarding one weight observed among individuals weight categories source health messages discussed due reinforcing stigmatizing notions present study sought investigate whether health messages eat healthy become physically active potential increase explicit implicit participants community randomized either experimental group control group presented health messages presented neutral information manipulation participants completed measures explicit implicit paired samples test revealed differences explicit manipulation however small effect decrease implicit found study provided evidence health messages might differential impact change according dual model approaches explicit implicit tap two different information processing systems thus differentially affected health messages brief exposure health messages might potential contribute health behavior mitigate implicit
type diabetes autoimmune disease resulting cell mediated beta cell destruction pancreas genetically susceptible individuals extensive familial population genetic studies uncovered strong linkage association hla gene variants non hla genes also associated ins ctla ptpn considered one heritable common diseases however evidence monozygotic twins incomplete concordance disease susceptibility provides convincing proof environmental factors also play important roles pathogenesis disease environmental factors induce alterations gene expression via epigenetic mechanisms epigenetic modifications refer alterations gene expression without changes dna sequence instead occur result dna methylation histone modifications mirna regulation aberrant epigenetic modifications cause dysregulation gene expression thus leading variety human diseases significant differences dna methylation histone modifications mirna profiling found patients compared healthy individuals epigenetic modifications contribute pathogenesis mainly regulating expression susceptible genes susceptible genes involved antigen presentation hla immune tolerance foxp ctla autoreactive cell response gad beta cell functions ins better understanding epigenetic mechanisms regulating susceptible genes help identify candidates target epigenetic pathways control prevent knowledge epigenetic changes also provides potential biomarkers diagnosis prognostication personalized treatment prevention disease
number portable wearable devices increasing population developed countries meanwhile capacity monitor register data people habits locations also complex data intensity strength movements created opportunity contribution general wealth sustainability environments ambient intelligence intelligent decision making processes benefit knowledge gathered devices improve decisions everyday tasks planning navigation routes car bicycle means transportation avoiding route perils current applications area demonstrate usefulness real time system inform user conditions surrounding area nevertheless approach work aims describe models approaches automatically identify current states traffic inside cities relate information knowledge obtained historical data recovered ubiquitous pervasive devices objective delivered analysing real time contributions devices identifying hazardous situations problematic sites defined criteria significant influence towards user well economic environmental aspects defined sustainability definition
optimal design strategy based genetic algorithms proposed nonlinear hysteretic control devices prevent pounding damage achieve best results seismic response mitigation two adjacent structures integrated fuzzy controller used order provide interactive relationships damper forces input voltages dampers based modified bouc wen model furthermore linear quadratic regulator lqr lqg linear quadratic gaussian controllers based clipped voltage law cvl also used compare results obtained fuzzy controller study employs main objectives optimal design reduce seismic responses also minimize total cost damper system set pareto optimal solutions also conducted corresponding results obtained optimal surface pareto solutions study result decreasing number dampers necessarily increase efficiency system fact reducing number dampers dynamic response system contribute increasing number dampers elsevier ltd rights reserved
anti tumor necrosis factor alpha anti tnf alpha therapy widely used management rheumatologic diseases frequent adverse effects anti tnf alpha therapy infections malignancies sarcoidosis rare condition hand anti tnf alpha therapy used treatment sarcoidosis elucidation paradoxical issue unclear article report ankylosing spondylitis patient diagnosed sarcoidosis period etanercept usage sarcoidosis possible adverse effect kept mind anti tnf alpha therapy
large scale science features complex dag structured workflows comprised computing modules intricate inter module dependencies mapping workflows heterogeneous network environments optimizing end end performance crucial success scientific collaborations require fast system response smooth data flow construct analytical cost models formulate workflow mapping optimization problems minimum end end delay maximum frame rate difficulty problems essentially arises topological matching nature spatial domain compounded resource sharing complicacy temporal dimension unitary processing applications develop workflow mapping algorithm based recursive critical path optimization procedure minimize latency streaming applications conduct rigorous workflow stability analysis develop layer oriented dynamic programming solution based topological sorting identify minimize global bottleneck time accuracy proposed exact delay calculation algorithm verified comparison approximate solution dynamic distributed system simulation program real network deployment performance superiority proposed mapping approaches illustrated extensive simulation based comparisons existing algorithms verified large scale experiments real life scientific workflows effective system implementation deployment real networks
interpreters play crucial role many investigative interviews child complainants sexual abuse however little written interpreting process perspective interviewers study elicited interviewers perspectives challenges using interpreters aim understanding investigative interviews could improved participants consisted investigative interviewers prosecutors child abuse cases range jurisdictions use interpreters regular basis thematic analysis semi structured interviews professionals interpreting process revealed two main challenges particular child abuse interviews namely interpreters lack preparedness deal traumatic sensitive nature children abuse histories insufficient understanding best practice child interview process recommendations focus need specialised training screening interpreters extensive use pre conferencing familiarise children interpreter mediated interview process
paper presents new three inputs one output current mode universal filter employing one modified current differencing transconductance amplifier mcdta two grounded capacitors filter realize low pass bandpass high pass band stop pass responses appropriately connecting input terminals realize filtering functions without component matching conditions inverting type input signal requirements natural frequency electronically controlled bias currents mcdta active passive sensitivity filter low pspice simulation results performed confirm presented theory
quorum sensing molecules qsms involved regulation complicated processes helping bacterial populations respond changes cell density although gene cluster comqxpa identified genome sequence bacilli system licheniformis investigated detail qsm comx pheromone identified given importance antagonistic bacterium industrial workhorse study aimed elucidate licheniformis ncimb results obtained bioinformatics studies whole genome sequence strain confirmed presence essential quorum sensing related genes although polymorphism verified three proteins cluster comq precursor comx comp transcription factor coma confirmed conserved protein cell cell communication licheni formis ncimb investigated elucidation comx pheromone amino acid peptide peptide sequence pheromone described biochemical characterisation
objective dsm introduces mild neurocognitive disorder mincd syndrome recognizes potential clinical importance acquired cognitive deficits mild qualify diagnosis dementia provide new empirical data mincd including total age sex specific prevalence rates number types neurocognitive domains impaired diagnostic overlap well established mild cognitive impairment mci concept design cross sectional results observational cohort study life adult study setting general population participants total dementia free individuals aged years measurements calculated weighted point prevalence rates confidence intervals mincd analyzed diagnostic overlap mincd mci calculating overall percentage agreement cohen kappa coefficient results weighted total prevalence mincd prevalence similar sexes significantly higher older age two thirds individuals mincd showed impairment restricted one six possible neurocognitive domains learning memory frequently impaired domain mincd cases followed social cognition analysis diagnostic overlap mci yielded overall agreement kappa conclusions considering six predefined neurocognitive domains study observed substantial proportion dementia free older adults mincd provision information underlying etiology ies may prime importance future studies aiming evaluating clinical relevance mincd syndrome
many studies focused supporting orchestral performers studies researchers helped multiple players perform without conductors using system conducts orchestra artificial virtual conductors several approaches taken field conduct players using conductor made computer graphics others conduct changing moving figures however studies demonstrated conduct specific instructions player propose group personalized virtual conductors group players orchestra date studies virtual conductors addressed single conductor however required dynamics tempo nuances different based player role part personalized conduct may desirable developed prototype includes group personalized virtual conductors found tendency better players listeners
backround previous studies demonstrated contributions genetic variants positive psychological traits gratitude forgiveness well however little known genes interact positive traits affect well methods investigate extent comtvamet polymorphism modulates well extent dispositional gratitude forgiveness mediate individual differences well participants recruited required complete battery questionnaires results found individuals smaller number met alleles reported greater well less depressive symptoms greater tendencies gratitude forgiveness moreover dispositional gratitude forgiveness mediated genotype effects well depressive symptoms results remained significant controlling non genetic factors socioeconomic status religious beliefs romantic relationship status parenting style limitation sample size limits generalizability results conclusion study demonstrates contribution comt vamet polymorphism individual differences well suggests potential psychobiological pathway dopaminergic noradrenergic systems happiness
throughout history seen concept fatherhood modified due changes different societies gone men patterns behavior toward pregnancy childbirth parenting evolved affective fatherhood forms merely related material suppliers aforementioned brought case loss child perinatal period males experience significant impact psychological psychosocial aspects affects quality life purpose paper briefly present information topic well clinical experience psychological management parenthood perinatal loss men
atr ehec cross protection effects thus induced lead uncertainty food safety study aimed identify factors associated atr ehec stomach acidity using rna seq total degs coil deg coli acid treatment identified including upregulated downregulated ehec upregulated downregulated coil atcc according results facing atr environment protein asr regulated whole add resistance process coli atcc cada cadb mediate lysine decarboxylation consumed extra protons inside keep neutral value cytoplasm protect coli death contrast oxidation reduction mediated ahpc activated depression oxyr hydrogenation mediated mhpa consumed protons inside keeping neutral value protect ehec harm induced low environment addition ehec expressed anti oxidation enzymes repair damage caused acid stress enhanced resistance acid compared coli atcc elsevier ltd rights reserved
human immunodeficiency virus hiv infectious agent attacks immune system cells without strong immune system body becomes susceptible serious life threatening opportunistic diseases spite great progresses medication prevention last years hiv infection continues major global public health issue claimed million lives last years since recognition disease monitoring registries hiv aids cases vital assess general health care needs support long term health policy control planning surveillance systems therefore established almost developed countries typically complex system depending several stakeholders health care providers general population laboratories challenges efficient effective reporting diagnosed cases one issue often arises administrative delay reports diagnosed cases paper aims identify main factors influencing reporting delays hiv aids cases within portuguese surveillance system used methodologies included multilayer artificial neural networks mlp naive bayesian classifiers support vector machines svm nearest neighbor algorithm knn highest classification accuracy precision recall obtained mlp results suggested homogeneous administrative clinical practices within reporting process guidelines reductions delays therefore developed nationwise transversally stakeholders
conducted exploratory review current literature child sexual abuse disclosure everyday contexts aim study provide overview relevant publications process child sexual abuse disclosure order generate new directions future research clinical practice findings exploratory review show disclosure relational process renegotiated interaction evolves extended period time characteristics reactions interaction partner appear critical process behavior words children methodological limitations review publications discussed well directions future research implications practice
practice rainwater harvesting rwh spreading rapidly urban areas article studies impact possible generalization practice municipalities proposing new method quantify potential potable water savings ppws using rainwater harvesting urban level proposed method based adaptation already validated model assessing ppws single buildings use urban databases two concepts introduced building type allows gathering buildings sharing common features equivalent building used assess ppws set buildings building type single building case municipality colombes located suburbs paris method shows ppws using rainwater harvesting represents total potable water consumption residential buildings account potential method applied municipalities level acceptable reliability regard means implemented terms collecting information
paper explores modeling design miller based operational amplifier structures highly immune electromagnetic interference emi proposed cmos miller based operational amplifier derived using present modeling provides higher immunity emi injected amplifier input wide range frequencies moreover frequency response comparable miller operational amplifier simulation results show maximum emi induced input offset voltage proposed cmos operational amplifier emi frequency mhz mvpp emi signal applied input contrast standard miller operational amplifier generates input offset voltage operating conditions developed mathematical modeling emi induced offset correlates circuit simulations providing superior accuracy designing high emi robustness
soluble microbial products smps act disinfection byproduct dbp precursor besides natural organic matter nom source water polluted biologically treated wastewater effluent smps main component influential factors smps dbp precursor investigated study model feed substrates biologically incubated simulate biological treatment wastewater organics smps produced chlorinated according standard procedure study dbp formation potential dbpfp smps feed chemical type crucial factor affecting smp production following dbp formation smps four kinds model feed substrates initial organic carbon concentration produced dbps wide range also different dbp formation properties different organic substrates would facilitate growth different microbial species produce smps varied levels chemical structure subsequently different dbp formation characters environmental factors anaerobic condition showed significant effect producing extremely high chloral hydrate probably due production volatile fatty acids different incubation conditions bring different levels smps dbps also smps different dbp formation feathers
background aims deficits social cognitive abilities including emotion recognition theory mind tom play significant role interpersonal difficulties observed alcohol use disorder aud meta analysis aims estimate mean effect sizes deficits social cognition inaud examines effects demographic clinical confounding factors variability effect sizes across studies methods literature review conducted research reports published january january twenty five studies investigating tom facial emotion recognition performances individuals aud healthy controls selected applying inclusion exclusion criteria weighted effect sizes calculated tom decoding reasoning aspects tom total facial emotion recognition recognition six basic emotions results facial emotion recognition significantly impaired confidence interval particularly disgust anger audwas also associated deficits tom deficits evident tasks measuring decoding reasoning aspects tom longer duration alcohol misuse depressive symptoms associated severe deficits recognition facial emotions conclusions alcohol use disorder appears associated significant impairment facial emotion recognition theory mind
megasat software enables genotyping microsatellite loci using next generation sequencing data microsatellites amplified large multiplexes sequenced pooled amplicons megasat reads sequence files automatically scores microsatellite genotypes uses fuzzy matches allow sequencing errors applies decision rules account amplification artefacts including nontarget amplification products replication slippage pcr amplification stutter differential amplification alleles important feature megasat generation histograms length frequency distributions amplification products locus individual histograms analogous electropherograms traditionally used score microsatellite genotypes enable rapid evaluation editing automatically scored genotypes megasat written perl runs windows mac linux systems includes simple graphical user interface demonstrate megasat using data guppy poecilia reticulata genotype guppies microsatellites per run illumina miseq sequencer evaluated accuracy automatically called genotypes using two methods based pedigree repeat genotyping data obtained estimates mean genotyping error rates estimates three loci accounted disproportionate fraction genotyping errors conversely loci scored detected error error rate results show appropriate selection loci automated genotyping
study aims analyse integration solar photovoltaic electric vehicle farm mechanisation operation sustainable development oil palm plantation industry malaysia multiple integration methods simulated primary considerations comprise energy costs capital expenditure net present costs percentage renewable energy contribution simulation results revealed board solar photovoltaic system best suited method compared setups actual field test selected system carried validate simulation study results produced roughly similar percentage solar energy contribution range addition study also conducted effects extra weight added vehicle results revealed less additional power required electric vehicle move constant velocity addition solar panels frame operational costs various practices include knapsack sprayer internal combustion engine vehicle selected system compared herbicide spraying found selected system could provide lowest operational costs per area could avoid carbon dioxide equivalent per hectare per year total diesel fuel consumption finally concluded integration solar photovoltaic electric vehicles could provide numerous advantages people planet well profit elsevier ltd rights reserved
behaviour central many fields metatheoretical definitions specifying basic assumptions considered behaviour largely lacking transdisciplinary research explores challenges defining behaviour highlighting anthropocentric biases frequent lack differentiation physiological psychical phenomena meet challenges article elaborates metatheoretical definition behaviour applicable across disciplines allows behaviours differentiated kinds phenomena definition used explore phenomena language scrutinise whether conditions language considered behaviour metatheoretical concept two different levels meaning conveyed human language introduced highlighting language inherently relies behaviours content said constitute interpersonal behaviour particular conditions analyses reveal ways language meaningfully extends human behavioural possibilities pushing far beyond anything enabled non language behaviours novel metatheoretical concepts complement expand existing theories behaviour language contribute novel piece theoretical explanation regarding crucial role language played human evolution
social network analysis become prominent tool study animal social life increasing need develop new systems collect social information automatically systematically reliably explore use freely accessible automated learning device monkeys aldm collect social information group captive baboons papio papio compared social network obtained presence baboons ten aldm testing booths social network obtained standard behavioral observation techniques results show presence network accurately reflects social organization group also indicate conditions presence network informative particular best correlation two networks obtained minimum days computer records individuals least records per day also show random permutation tests observed correlations beyond would observed simple synchronous activity reflect preferential choice closely located testing booths use automatized cognitive testing therefore presents new way obtaining large regular amount social information necessary develop social network analysis also opens possibility studying dynamic changes network structure time relation cognitive performance individuals
introduction due early late failures may occur surgically created hemodialysis arteriovenous fistulas savf post creation procedures commonly required facilitate avf maturation maintain patency study compared avf post creation procedures associated costs patients savf patients new endovascularly created avf endoavf methods random sample medicare standard analytical files abstracted determine post creation procedures associated costs savf created medicare enrollment months prior avf creation required patients follow inpatient outpatient physician claims used identify post creation procedures estimate average procedure costs comparative procedural information endoavf obtained novel endovascular access trial neat results medicare savf patients successfully matched endoavf patients using propensity score matching baseline demographic clinical characteristics total post creation procedural event rate within year lower endoavf patients per patient year compared matched savf cohort per patient year endoavf cohort event rates angioplasty thrombectomy revision catheter placement subsequent arteriovenous graft avg new savf vascular access related infection significantly lower savf cohort average first year cost per patient year associated post creation procedures estimated usd lower endoavf savf conclusions compared patients savf patients endoavf required fewer post creation procedures lower associated mean costs within first year
introduction palliative care approach caring patients families affected serious illnesses focuses relief suffering management medical symptoms psychosocial issues advance care planning spiritual wellbeing past decade emerging clinical research interest application palliative care approaches parkinson disease outpatient palliative care services offered several movement disorders centers methods international working group meeting palliative care supported parkinson disease foundation held october review current state evidence make recommendations clinical research practice results topics included defining palliative care lessons palliative care heart failure chronic illnesses patient caregiver needs needs assessment tools intervention strategies predicting prognosis hospice referrals choice appropriate outcome measures implementation dissemination education research need research collaborations provide overview discussions summarize current evidence practices highlight gaps knowledge make recommendations future research conclusions palliative care rapidly growing area holds great promise improving outcomes patients caregivers clinical research area build lessons learned diseases need observational methodological interventional research address unique needs patients caregivers elsevier ltd rights reserved
online behavioral advertising oba provides internet users potential benefit relevant ads harm privacy infringement personalized covert persuasion tactics making interesting case understanding perceptions media effects study survey found subjective persuasion knowledge oba positively related third person perception tpp importantly assessment potential harm benefit oba mediated relationship subjective persuasion knowledge tpp objective persuasion knowledge however indirectly related tpp via subjective persuasion knowledge tpp related personal accept avoid oba social level pro regulation coping measures study experiment replicated study showed perceived effect oba self others drove tpp responses personal outcome measures implications understanding perceived media effects response oba discussed elsevier ltd rights reserved
modern semiconductor detectors allow charged particle tracking ever increasing position resolution due reduction spatial hit uncertainties multiple coulomb scattering detector layers becomes dominant source tracking uncertainties case long distance effects ignored momentum measurement track fit consequently formulated sum independent fits hit triplets paper present analytical solution three dimensional triplet fit homogeneous magnetic field based multiple scattering model track fitting hit triplets performed using linearization ansatz momentum resolution discussed typical spectrometer setup furthermore track fit compared track fits two different pixel detector geometries namely mue experiment psi typical high energy collider experiment large momentum range triplets fit provides significantly better performance single helix fit triplets fit fast easily parallelized makes ideal implementation parallel computing architectures
key predistribution schemes resource constrained networks methods allocating symmetric keys devices way provide efficient trade key storage connectivity resilience many suggested constructions key predistribution schemes general understanding design principles base constructions somewhat lacking indeed even tools develop understanding currently limited results many relatively hoc proposals research literature suggested large edge expansion coefficient key graph desirable efficient key predistribution schemes however attempts create key predistribution schemes known expander graph constructions provided extreme trade connectivity resilience namely provide perfect resilience expense substantially lower connectivity achieved key storage contribution twofold first prove many existing key predistribution schemes produce key graphs good expansion provides support justification use confirms validity expansion sound design principle second propose use incidence graphs concurrence graphs tools represent design analyse key predistribution schemes show tools lead helpful insights new constructions
variable speed wind turbine vswt employing permanent magnet synchronous generator pmsg uses full scale back back converter totally decouples rotating parts wind turbine generator electrical network therefore inertial contribution pmsg vswt primary frequency regulation modern trend synthesize active power control apc capability benefits fast response converter change active power production frequency disturbance paper introduces proposed apc algorithm pmsg vswt order imitate response conventional synchronous generator proposed apc method uses two auxiliary torque control loops first emulated inertia control loop based effective inertia constant depends wind power produced second droop control loop two loops extract instantaneous active power needed primary frequency regulation stored kinetic energy rotating mass pmsg vswt design proportional integral controllers generator side converter gsc based decoupled diagonal internal model control ddtmc method simulations using matlab simulink performed different wind speeds frequency drop caused insertion large loads comparative results presented verify effectiveness robustness proposed apc method
analytical method based magnetic equivalent circuits mec widely used preliminary machine design due short calculation time low computational cost calculate result normally considered accurate finite element method fem address mec less accurate fem time consuming challenge novel design analysis procedure permanent magnet synchronous generators pmsgs proposed paper initial physical electromagnetic features pmsgs presented mec first design stages electromagnetic analyses realized fem based electromagnetic simulation software field circuit coupled design method could facilitate accuracy shorten time cycle generator design using rmxprt simulation tool realized convenient fast modeling parametric analysis armature diameter axial length air gap number conductors per slots carried results show magnetic density distribution generators becomes better efficiency improved validity applicability method verified moreover provide basis optimization design generators
paper proposes conjugate gradient back propagation based artificial neural network real time power quality assessment novel real time voltage sag swell detection classification scheme using artificial neural network presented ann trained matlab using voltage sampled signal data corresponding parameters neural network utilized implement labview real time sag swell detection classification levenberg marquardt resilient back propagation conjugate back propagation algorithm performance evaluated matlab find best neural network real time application among three back propagation algorithms conjugate gradient algorithm better performance real time power quality monitoring mathematical model conjugate gradient back propagation neural network implemented labview real time voltage signals sag swell different time duration magnitude intensity acquired hardware experimental setup hardware setup mainly consists single phase voltage source microcontroller dimmerstat solid state relays voltage signals sag swell sensed using high precision voltage sensor data acquisition system used acquire signal voltage sensor output data acquisition system given personal computer labview proposed monitoring system also detects odd even harmonic components voltage signal acquired using fft real time hardware results obtained using proposed power quality monitoring system detection voltage sag swell harmonics claims suitability robustness adaptability monitor power quality issues elsevier ltd rights reserved
recent software engineering paradigms software product lines supporting development techniques like feature modeling cloud provisioning models platform infrastructure service allow great flexibility software design deployment resulting potentially large cost savings however flexibility comes catch combinatorial complexity optional design features deployment variability increases difficulty assessing system qualities scalability quality service increases software scalable instance specific set selected features deploying additional service instances futile endeavor clearly need systematically measure impact feature selection scalability potential cost savings completely mitigated risk system unable meet service demand work document results systematic load testing automated quality service scalability analysis major contribution work tool support methodology analyze scalability distributed feature oriented multi tenant software systems continuous integration process discuss approach select features load testing representative set feature combinations used elicit valuable information performance impact feature interactions additionally highlight methodology framework performance scalability prediction differs state practice solutions take viewpoint tenant service service provider report experiences applying approach industrial use case domain electronic payments conclude integration systematic scalability tests continuous integration process offers strong advantages software developers service providers ability quantify impact new features existing service compositions early detection hidden feature interactions may negatively affect overall performance multi tenant services elsevier inc rights reserved
evaluate diagnostic ability multi detector computed tomography mdct compared endoscopic ultrasonography eus standard reference investigate factors influencing detection small gastric subepithelial tumors sets mdct stomach protocol retrospectively investigated patients suspected gastric sets esophagogastroduodenoscopy egd underwent eus computed tomographic scanning eus performed two gastroenterologists location size echotexture echogenicity layer origin described gastric sets detected eus mdcts reviewed based consensus two radiologists blinded eus result size location enhancement pattern contour lesion detected described calculated diagnostic ability compared eus respect detection gastric sets investigated factors influencing detection sets also used receiver operating characteristic roc curve obtain optimal cut size predicting visibility small sets patients underwent eus due suspicious presence set egd eus detected probable cases set cases external compression led detection cases set cases sensitivity specificity respectively positive predictive value ppv negative predictive value npv respectively significant difference mean size detected lesions compared invisible lesions observed roc analysis revealed optimal cut value also referred prediction visibility cases cases identified external compression insignificant lesions lipoma hemangioma lymphangioma gastritis cystica require regular follow stomach shows good feasibility respect depiction small sets especially cases size larger henceforth proposed stomach would complimentary problem solving tool set evaluating presence external compression characterization tumors
paper consider pullback attractors non autonomous plate equations external term unbounded phase space prove existence pullback attractors omega omega omega omega
rapid increase size complexity analog systems implemented field programmable analog arrays fpaas need synthesis tools becoming necessity paper present simspice tool automatically converts analog signal processing systems simulink designs spice netlist tool top level complete chain automation tools allows signal processing engineers design analog systems block level implement systems reconfigurable analog hardware platform matter minutes provide detailed descriptions stage design process elaborate custom library analog signal processing blocks demonstrate several examples systems automatically compiled simulink blocks analog hardware
eye irritation example dry irritated eyes generally among top three reported symptoms office like environments particular among workplaces cognitive demanding visual display unit vdu work symptoms especially among middle advanced ages particularly among women men symptoms also among commonly reported complaints eye clinic position interpret high prevalence eye symptoms multidisciplinary integrated approach necessary involves external eye physiology separate internal eye effects eye diseases evaporative dry eye aqueous deficient gland dysfunctions risk factors aggravate stability precorneal tear film ptf resulting hyperosmolarity initiation inflammatory reactions indoor environmental occupational personal risk factors may aggravate ptf stability factors age contact lenses cosmetics diet draft gender low humidity high temperature medication outdoor combustion pollutants vdu work psychological stressors may influence reporting behavior eye symptoms impact risk factors may occur combined exacerbating manner
feature subset selection aim reducing dependency feature selection techniques obtaining high quality minimal feature subset real world domain main task research end firstly two types feature representation presented feature sets namely unigram based part speech based feature sets secondly five methods feature ranking employed creating feature vectors finally propose two methods integration feature vectors feature subsets ordinal based integration different feature vectors oifv proposed order obtain new feature vector new feature vector depends order features old vectors frequency based integration different feature subsets fifs effective features obtained hybrid filter wrapper methods feature selection task proposed addition four wellknown text classification algorithms employed classifiers wrapper method selection feature subsets wide range comparative experiments five widely used datasets sentiment analysis carried experiments demonstrate proposed methods effectively improve performance sentiment classification results also show proposed part speech patterns effective classification accuracy compared unigram based features elsevier ltd rights reserved
backgroundenvironmental stress affects gut dysmotility common consequence although variety microbes molecules may prevent dysmotility none reverse dysmotility methodswe used hour restraint stress mouse model test treatment effects neuroactive microbe rhamnosus motility fluid filled vivo gut segments perfusion organ bath recorded video migrating motor complexes measured using spatiotemporal maps diameter changes key resultsstress reduced jejunal increased colonic propagating contractile cluster velocities frequencies increasing contraction amplitudes luminal application ecfu restored motor complex variables unstressed levels within minutes application salivarius acetate treatment effects butyrate partially reversed stress effects colonic frequency amplitude propionate reversed stress effects jejunum colon except jejunal amplitude conclusions inferencesour findings demonstrate first time potential certain beneficial microbes treatment stress induced intestinal dysmotility mechanism restoration function occurs within intestine via rapid drug like action enteric nervous system
background development child behaviour parenting difficulties understood undermine treatment outcomes children atopic dermatitis past research reported correlates child behaviour difficulties however research studies sought examine parenting confidence practices clinical group objectives examine relationships child parent family variables parent reported directly observed child parent behaviour parents self efficacy managing difficult child behaviour self reported parenting strategies disease severity design cross sectional study design participants parent child dyads recruited dermatology clinic paediatric tertiary referral hospital brisbane australia children diagnosis atopic dermatitis months chronic health conditions except asthma allergic rhinitis allergy methods parents completed self report measures assessing child behaviour parent depression anxiety stress parenting conflict relationship satisfaction self efficacy managing difficult child behaviour use ineffective parenting strategies self efficacy managing atopic dermatitis performance atopic dermatitis management tasks scoring atopic dermatitis index used assess disease severity routine home treatment sessions coded parent child behaviour results pearson spearman correlations identified relationships self efficacy managing difficult child behaviour child behaviour problems parent depression stress parenting conflict relationship satisfaction household income also relationships variables use ineffective parenting strategies greater use ineffective parenting strategies associated severe atopic dermatitis using multiple linear regressions child behaviour household income explained unique variance self efficacy managing difficult child behaviour household income alone explained unique variance use ineffective parenting strategies self efficacy managing difficult child behaviour self efficacy managing atopic dermatitis positively correlated rho successful self reported performance atopic dermatitis management tasks correlated less permissive less authoritarian parenting directly observed aversive child behaviour associated severe atopic dermatitis parent stress parent reported child behaviour problems conclusion study revealed relationships parents self efficacy parenting practices across domains child behaviour management atopic dermatitis management parents children severe atopic dermatitis may difficulty responding child behaviour difficulties appropriately potentially impacting illness management incorporating parent parenting support within treatment plans may improve child family wellbeing also treatment outcomes elsevier ltd rights reserved
introduction increasing prevalence chronic diseases health care services offering support therapeutic patient education tpe acquiring certain skills patient takes active role day day management disease however may difficult patients continue working tpe providers handle occupational health issues education systems methods descriptive study examines occupational health component ile france tpe programmes two conditions chronic low back pain adult asthma data obtained cart website via telephone interviews eighteen tpe programme coordinators conducted according interview guide results analysis results combining statistical content analysis shows approach occupational health terms skills content tpe practices different two conditions asthma tpe programmes tend stress management asthma attacks avoidance risky situations knowledge occupational trigger factors low back pain tpe programmes hand prioritize continued employment main objective emphasize use adaptation behaviours reducing fears beliefs conclusion current educational formats largely neglect occupational health occupational health physicians could possibly enlisted help make tpe programmes effective domain
research video game violence focused impact aggression far neglected processes mechanisms underlying enjoyment video game violence present contribution examines specific process context namely players strategies cope moral concern would real life settings arise violent actions based bandura theory moral disengagement argue order maintain enjoyment game violence players find effective strategies avoid cope moral conflict related violent behaviors game world moral management exploratory interviews ten players violent video games revealed relevance moral reasoning game enjoyment several strategies help players manage moral concern importantly respondents referred game reality distinction focus winning game explaining violent action product good performance findings discussed light theorizing moral management potential links media violence debate
whether use inhaled corticosteroids ics protects patients chronic obstructive pulmonary disease copd lung cancer remains undetermined retrospective nationwide population based cohort study extracted data female copd patients ics users ics non users diagnosed taiwan national health insurance database patients followed lung cancer incidence determined cox regression analysis used estimate hazard ratios hrs lung cancer incidence time lung cancer diagnosis significantly different ics users non users years significantly associated lower risk lung cancer ics users age years pneumonia diabetes mellitus hypertension decreased lung cancer risk whereas pulmonary tuberculosis increased risk results suggest ics potential role lung cancer prevention among female copd patients
treatment options patients eisenmenger syndrome recently scarce new knowledge field pulmonary arterial hypertension expanded therapeutic possibilities patients advanced therapy pulmonary vasodilators become part standard treatment offering long term benefits exercise capacity clinical symptoms possibly survival however currently studies guide use advanced therapies population important questions indications initiation escalation advanced therapy valid effect parameters treatment goals remain unanswered review covers pharmacology therapeutic options risk stratification treatment strategy pulmonary arterial hypertension specific drugs patients eisenmenger syndrome
present paper general framework study issues effective load balancing scheduling highly parallel distributed environments currently built cloud computing systems propose novel approach based concept sandpile cellular automaton decentralized multi agent system working critical state edge chaos goal providing fairness concurrent job submissions minimizing slowdown individual applications dynamically rescheduling best suited resources algorithm design experimentally validated number numerical experiments showing effectiveness scalability scheme presence large number jobs resources ability react dynamic changes real time
oil palm plantations expanded around world increasing concern pressure deforestation rates homogenization landscape context present study aimed evaluate impact oil palm plantations physical characteristics streams amazonia effects heteroptera odonata fish assemblages total streams sampled eight within fragments primary forest oil palm plantations data collected characteristics channel morphology substrate hydraulics instream cover aquatic organisms riparian vegetation human impacts woody debris instream cover proximity human impacts variables greatest effects physical structure streams showing variation streams forest pristine areas oil palm plantations analyzed parameters substrate instream cover woody debris influence richness heteroptera odonata fish impact oil palm plantations local streams depended size plantations considered adequate substitute lost habitats efforts preserve physical habitat amazonian streams type conversion natural forest direct indirect impacts dynamics structure environments potentially negative consequences biodiversity maintenance adequate buffer zone native riparian vegetation adjacent streams flow plantations recommended appears principal factor determining physical conditions streams copyright john wiley sons ltd
purpose study determine whether comorbid adolescent criminal substance involvement acsi predictive adult criminal substance involvement adolescent criminal substance involvement alone identify potential precursors mediators relationship using data members four wave national longitudinal study adolescent health add health found acsi wave ages predicted adult criminal substance involvement waves ages ages addition antisocial cognition wave partially mediated relationship acsi wave criminal substance involvement wave wave school problems correlated independent dependent mediating variables theoretical practical implications study include role early school problems development acsi significance antisocial thinking maintaining involvement
exposure stress activates hypothalamic pituitary adrenal axis leads increased levels glucocorticoid hormones prolonged elevation levels causes neuronal dysfunction decreases density synapses impairs neuronal plasticity decreased sensitivity glucocorticoids glucocorticoid resistance develops result chronic stress one characteristic features stress induced psychopathologies article reviewed published data proposed molecular mechanisms contribute development glucocorticoid resistance brain including changes expression glucocorticoid receptor gene biosynthesis isoforms posttranslational modifications also present data alterations expression fkbp gene encoding main component cell ultra short negative feedback loop signaling regulation recent discoveries stressand grinduced changes epigenetic modification patterns well normalizing action antidepressants discussed fkbp gene polymorphisms associated stress induced psychopathologies described role glucocorticoid resistance discussed
limited studies prevalence correlates sexual risk behavior among adolescents pacific island countries order inform public sexual reproductive health interventions aim study assess prevalence correlates various sexual risk behaviors among school adolescents pacific island countries using data global school based health survey cross sectional study school going adolescents boys girls years old fiji kiribati samoa vanuatu surveyed self administered questionnaire overall students reported ever sex ranging vanuatu samoa sexually active early sexual debut years sexual partners lifetime used condom last sex used birth control last sex engaged sexually risky behavior using composite measure multivariate logistic regression found male sex older age tobacco use alcohol use mental distress close friends truancy associated several sexual risk behaviors sexual reproductive health promotion programs indicated address high risk sexually transmitted infection hiv pregnancy adolescent population
reduced amplitude event related potential consistently associated variety externalising problems including conduct disorder available genetically informative studies relationships however conducted among adolescents adults age conduct disorder typically already become manifest among general population twins mean age years range years studied relationship waveform elicited auditory oddball task dsm oriented conduct problems scale child behavior checklist conduct problems scores negatively significantly correlated amplitude correlations amplitude dsm oriented child behavior checklist scales non significant except oppositional defiant problems found moderate heritability estimates amplitude conduct problems bivariate twin analyses indicated covariation two phenotypes explained additive genetic factors genetic correlation association reduced amplitude conduct problems substantiated already childhood age precedes typical onset conduct disorder relationship appears genetic nature reduced amplitude represent valuable marker conduct problems contribute early identification children high risk conduct disorder
automatic generation procedures combinatorial optimization problems emerging new alternative address hardest problems class one problems still offering great computational difficulty traveling salesman problem simple presentation masks great difficulty exists solving numerically results obtained far problem based hybridization known heuristics however still need experimental breakthrough study possible combinations heuristics represents huge search space paper explore space using evolutionary computing automatically design new algorithms problem carried computational experiment produce algorithms competitive existing heuristics also contain several novel structures directly influence performance
present general method transferring skeletons skinning weights characters distinct mesh topologies pipeline takes inputs source character rig consisting mesh transformation hierarchy joints skinning weights target character mesh inputs compute joint locations orientations embed source skeleton target mesh well skinning weights bind target geometry new skeleton method consists two key steps first compute geometric correspondence source target meshes using semi automatic method relying set markers resulting geometric correspondence used formulate attribute transfer energy minimization filtering problem demonstrate approach variety source target bipedal characters varying mesh topology morphology several examples demonstrate target characters behave well animated either forward inverse kinematics via examples show method preserves subtle artistic variations spatial relationships geometry joints well skinning weight details accurately maintained proposed pipeline opens many exciting possibilities quickly animate novel characters reusing existing production assets
characteristic compact structure low inertia high rigidness accuracy parallel mechanisms worthwhile popularized field agricultural robotization especially situations require precise movement limited space focusing harvesting task strawberries ridge culture pppr robot manipulator three translational dof one rotational dof devised paper type synthesis method set theory used design topology structure space compared traditional machine design methods synthesis method allow one decide manipulator configuration topdown logic initially appointed features manipulator moving platform software simulation carried demonstrate mechanism meet movement requirements driving four active joints allocated fixed platform
linguistic cognitive abilities manifest huge heterogeneity children autism spectrum disorder asd children present commensurate language cognitive abilities others show variable patterns development using spontaneous language samples investigate presence extent grammatical language impairment heterogeneous sample children asd findings sample suggest children asd categorized three meaningful subgroups normal language marked difficulty grammatical production relatively intact vocabulary globally low language abilities findings support use sensitive assessment measures evaluate language autism well utility within disorder comparisons order comprehensively define various cognitive linguistic phenotypes heterogeneous disorder
flutter instability hazardous wind induced vibration long span suspension bridge study first built long span triple tower suspension bridge china taizhou yangtze river bridge taken example three dimensional flutter stability analysis bridge conducted based ansys parametric analysis structural flutter stability performed parameters studied paper include sag span ratio stiffness main girder dead load main girder rigid central buckle longitudinal stiffness middle tower cable system result shows torsional stiffness main girder sag span ratio cables central buckle cable system significant influence flutter stability bridge among sensitive parameters found paper influence cable system prominent however influences stiffness main girder longitudinal stiffness middle tower dead load deck limited results provide reference information wind resistance design long span triple tower suspension bridges future elsevier ltd rights reserved
order improve efficiency product design reuse heterogeneous system knowledge sharing paper introduced concept ontology product variant design grinding machine design example lot experience accumulated knowledge product design shared reused precisely formulate ontology knowledge variant design features parameter applied software protege construct ontology model well runed resoning model data information developed set complete product intelligent system variant design effectively solve problem repeated design greatly shorten product development cycle
wound dressing plays irreplaceable role preventing infection accelerating healing wounds especially chronic non healing wounds recently electrospun silk fibroin fibrous matrices regarded ideal candidate wound healing virtue excellent skin affinity good permeability air water manuka honey demonstrated unique properties wound healing including anti inflammatory anti bacterial function well promoting tissue growth reducing pain patients report feasibility developing composite fibrous matrices antimicrobial wound dressing fibrous matrices loading different amount manufactured green electrospinning ftir spectra indicated successfully loaded fibers composite fibers show smooth morphology diameter increases content increased interestingly incorporation significantly improved antimicrobial activity fibrous matrices without negative effect excellent biocompatibility moreover composite fibrous matrices showed good performance improving wound healing according data animal experiment findings suggest prepared natural green composite matrices combining merits could promising candidate wound dressing elsevier ltd rights reserved
modified solar distillation system different nanofluids emerging application area added various nanoparticles saline water enhance ability solar energy absorption storage however lacked exploration performance nanofluids saline water therefore stability optical properties thermal conductivity sic saline water based nanofluids systematically investigated study experimental results showed sic nanofluids good effects enhancing thermal conductivity respect base fluids increase vol sic nanofluids good capacity solar absorption luminousness vol sic nanofluids increase salt concentration negative effects affect nanofluids stability thermal conductivity therefore appropriate salt concentration range nanoparticles load measured practical application moreover vol sic nanofluid prepared natural seawater sufficient stable period thermal conductivity seawater based nanofluid enhanced respect base fluid good stability low luminousness effective thermal property sic nanofluids confirmed feasibility nanofluids application solar distillation system elsevier ltd rights reserved
work addresses modeling high pressure electric discharge arc heated wind tunnel combined numerical solution poisson equation radiative transfer equations set favre averaged thermochemical nonequilibrium navier stokes equations allows determination electric radiation flow fields accounting mutual interaction semi classical statistical thermodynamics used determine plasma thermodynamic properties transport properties obtained kinetic principles chapman enskog method multi temperature formulation used account thermal non equilibrium finally turbulence closure flow equations obtained means spalart allmaras model requires solution additional scalar transport equation streamline upwind petrov galerkin stabilized finite element formulation employed solve navier stokes equation electric field equation solved using standard galerkin formulation stable formulation radiative transfer equations obtained using least squares finite element method developed simulation framework applied investigate turbulent plasma flows aerodynamic heating facility nasa ames research center current model able predict process energy addition distribution due joule heating thermal radiation resulting hot central core surrounded colder flow use unsteady three dimensional treatment also allows asymmetry due dynamic electric arc attachment point cathode chamber captured accurately current work paves way detailed estimation operating characteristics arc heated wind tunnels critical testing thermal protection systems
background purposeto describe methodology interim baseline longitudinal magnetic resonance imaging mri acquisition parameter characteristics multiple sclerosis clinical outcome mri united states mrius material methodsthe mrius ongoing longitudinal retrospective study patients fingolimod clinical brain mri image scan data collected patients across centers united states mri brain outcomes included change whole brain volume lateral ventricle volume lesion volumes new enlarging gadolinium enhancing lesions resultsinterim baseline longitudinal mri acquisition parameters results presented patients mean age years female forty percent scans dimensional sequence preindex period increasingto postindex period use dimensional sequence decreased time preindex period postindex scans flair considered acceptable good quality compared notable changes mri hardware software coil preindex index index postindex mri sequence parameters orientation thickness protocol differed index postindex scans flair respectively conclusionsthe mrius study linked clinical brain mri outcomes integrated database create cohort fingolimod patients real world practice variability observed mri acquisition protocols overtime
amphiphilic nonspherical particles asymmetric surface physical chemical properties unique structure makes suitable applications many areas chemical biological sensors colloidal surfactants self assembly building blocks complex superstructures materials engineering study amphiphilic sulfonated polystyrene polystyrene sps composite particles controllable morphologies synthesized combining modified treatment multistage seeded swelling polymerization core shell sps particles first obtained modifying cross linked particles concentrated sulfuric acid surface sps particles hydrophilic sulfonated polystyrene layer twice seeded swelling polymerization new hydrophobic oil phase sprouted strong hydrophilic surface even without surfactant assistance aqueous media morphologies sps composite particles could adjusted changing crosslinking density seed microspheres sulfonation temperature swelling ratio monomer seed polymer composite particles used solid surfactants elsevier ltd rights reserved
objective symptoms sluggish cognitive tempo sct considered potential subset symptoms adhd predominantly inattentive presentation adhd separate related symptom dimension sought characterize relationships sct internalizing symptoms executive functioning adults adhd method one hundred two adults diagnosed adhd completed clinical interviews clinical rating scales hierarchical regression analyses conducted ascertain independent predictive power sct symptoms executive dysfunction considering adhd inattentive hyperactive impulsive symptoms internalizing symptoms results sct correlated adhd inattentive symptoms dimensional measures depression anxiety symptoms clinical diagnosis depression anxiety disorder sct independently predictive executive function deficits effects internalizing adhd symptoms conclusion sct adults associated internalizing symptoms adhd inattentive symptoms independently executive function deficits particularly organization problem solving att dis xxxx
pile foundations usually used heavy superstructural loads transmitted weaker subsoil piles also subjected significant amounts lateral loads overturning moments besides axial loads lateral loads order vertical loads case onshore structures whereas case coastal offshore structures lateral loads exceed vertical loads therefore proper attention given designing pile structures lateral loads recent years many investigations addressed externally bonded fiber reinforced polymer composites strengthening concrete structures paper presents experimental study glass carbon fiber reinforced polymers gfrp cfrp strengthened reinforced concrete piles subjected cyclic lateral loads effects gfrp cfrp strengthening piles studied load deflection stiffness degradation energy dissipation piles also presented american society civil engineers
manufacturing technology high power laser optical elements belongs typical extreme manufacturing engineering high precision low defect outputs less cost order resolve bottleneck current manufacturing paper introduces cloud manufacturing service mode oriented high power laser optical elements realize digital engineering management within optical product life cycle discusses architecture key techniques new mode cloud manufacturing service mode allocate manufacturing resources capabilities properly provide managing mechanism used need paid according need utilize different resource services anywhere useful manufacture high power laser optical elements improve manufacturing precision optical damage resistance threshold production efficiency
incidence psoriasis africa middle east afme high regions represents significant problem dermatologists patients psoriasis morbidities obesity cardiovascular disease psoriatic arthritis psa also particularly common regions may recognized treated despite regional guidelines aid physicians appropriate use biologic agents clinical practice limited group expert dermatologists across afme region surveyed help establish best practice across region alongside supporting data literature although biologics significantly improved patient outcomes since introduction results survey identified several unmet needs including lack consensus regarding use clinical practice discrepancy also exists among afme physicians concerning clinical relevance immunogenicity biologics despite increasing data across inflammatory diseases significant treatment management challenges psoriasis patients remain move towards individualized tailored care may help address issues development specific local guidelines treatment psoriasis psa could also step towards understanding distinct patient profiles regions
paper present overview entropy production fluid dynamics systematic way first clarify rigorous derivation incompressible limit navier stokes fourier system equations based asymptotic analysis well known mathematical technique used derive macroscopic limits kinetic equations chapman enskog expansion hilbert expansion popular methodologies allows overcome theoretical limits assuming material derivative density simply vanishes moreover show fundamental gibbs relation classical thermodynamics applied non equilibrium flows generalizing entropy expressing second law thermodynamics case incompressible compressible flows consistent thermodynamics irreversible processes essential condition design optimization fluid flow devices summarizing theoretical framework valid different regimes incompressible compressible sheds light entropy production fluid mechanics broad implications applied mechanics
high neighborhood social capital could facilitate earlier diagnosis hiv higher rates linkage hiv care engagement multivariate analysis used examine whether social capital social cohesion social participation collective engagement associated lower year average prevalence late hiv diagnosis linked hiv care engaged hiv care within philadelphia united states census tracts higher average neighborhood social participation associated higher prevalence late hiv diagnosis linked hiv care lower prevalence engaged hiv care higher collective engagement associated lower prevalence linked hiv care findings different directions associations among social capital indicators hiv related outcomes underscore need nuanced research topic include longitudinal assessment across key populations
controller area network flexible data rate attracting attention next generation vehicle network technology however security issues completely taken account designing although every bit information transmitted could critical driver safety fail solve security vulnerabilities expect vehicle information communications technology vehicle ict convergence continue develop fortunately secure vehicle communication environments constructed using larger data payload paper propose security architecture vehicle countermeasure designed accordance specifications considered characteristics international organization standardization iso automotive safety integrity level vehicle subnetwork design practical security architecture also evaluated feasibility proposed security architecture using three kinds microcontroller unit canoe software evaluation findings may used indicator performance level electronic control units manufacturing next generation vehicles
paper influence magnetic material degradation optimal design parameters electromagnetic devices presented investigation carried incorporating mechanical stress constitutive laws magnetic material single valued iron loss characteristics means parametric magneto mechanical model optimization problem formulated redesigning electromagnetic device reach predefined target performance application widely used electromagnetic device surface mounted permanent magnet synchronous machine studied presented results depict electromagnetic device easily redesigned adapting values flexible design parameters compensate effect magnetic material degradation achieve target performance paper help designers electrical machines improve quality machine design
purpose osteoporosis fragility fractures consequences individual level overall health care system although dual energy ray absorptiometry dxa reference standard assessing bone mineral density bmd simpler tools may able screen bone quality provisionally signal need intervention hypothesized second metacarpal cortical percentage mcp calculated standard radiographs hand wrist would correlate hip bmd derived dxa could provide simple screening tool osteoporosis methods two hundred patients hand wrist radiographs hip dxa scans within year included series mid diaphyseal mcp calculated ratio cortical diameter total diameter assessed correlation mcp total hip bmd subjects stratified normal osteopenic osteoporotic cohorts based hip scores thresholds identified optimize screening sensitivity specificity results second metacarpal cortical percentage correlated significantly bmd scores hip mcp threshold less optimized sensitivity specificity discerning osteopenic subjects normal subjects whereas threshold less optimized sensitivity specificity differentiating osteoporotic normal subjects conclusions demonstrating global bmd may assessed mcp data suggest radiographs hand wrist may role accurately screening osteopenia osteoporosis simple investigation already used ubiquitously patients hand wrist problems may identify patients risk fragility fractures allow appropriate referral treatment copyright american society surgery hand rights reserved
objectivethis study aims provide review current literature interviewing children family law matters date resource practitioners might starting considering entering family law arena guide future research methodthis study literature review publications concerning purpose practice child interviews family law matters specifically review structured around following questions sought interviews children family law matters capacity children provide reliable information children children currently interviewed family law context resultsresearch interviewing children family law matters still infancy majority work concentrated providing guidelines principles suggestions interviews without evaluation whether guidelines suggestions utilised whether effective conclusionsno one yet extensively examined child interviews parenting disputes conducted overall aim future research therefore include investigation children actually interviewed reports family law proceedings effect known interviewing techniques family law context best practice interviewing developed applied assessments family law proceedings
work presents evaluation different teeth shape geometries tubular linear switched reluctance generator order maximize machine capabilities power generation low speeds direct drive wave energy converters phase generator different geometries proposed evaluated scope achieve greater electromotive force low speeds despite adopted control strategy optimization study support fem analysis different geometric parameters evaluated maximize inductance change relative displacement stationary mover parts machine
article presents design concept time gain compensation tgc amplifier integrated circuit ultrasonic echo signal processing tgc chain contains pre amplification attenuation filtering comparison circuit blocks chip oscillator bias circuit digital control core also included presented tgc concept blocks designed modeled using cadence design tools using cmos process operational amplifier implemented tgc gain bandwidth khz corresponds ultrasonic signal frequency range second order active band pass filter sallen key topology mhz center frequency filter quality factor ring oscillator external tuning capability modeled khz frequency deviation ultrasonic echo processing chain digital output length pulse corresponds received signal strength makes presented tgc concept suitable simple complex ultrasonic medical industrial research equipment
background tumor necrosis factor receptor associated periodic syndrome traps autosomal dominant autoinflammatory disease caused mutations tnfrsfa gene low penetrance variant usually associated milder traps phenotype structural pathogenic mutations studies differentiating related disease patients pediatric adult onset performed date objective analyze clinical features disease outcomes patients diagnosed traps associated variant investigate differences patients pediatric adult disease onset methods retrospective review patients related disease four reference centers autoinflammatory diseases performed clinical laboratory features family history autoinflammatory diseases treatments received outcomes follow recorded separately analyzed pediatric adult patients results included analysis reported pediatric adult rqrelated disease series results series encompassed patients females males variant patients disease onset occurred infancy adulthood median diagnostic delay years follow years positive family history autoinflammatory disease detected patients patients presented febrile recurrent episodes common symptoms included arthralgia arthritis myalgia asthenia fatigue abdominal pain headache odynophagia skin rash chest pain attacks patients increased acute phase reactants levels patient developed amyloidosis study period end follow patients asymptomatic treatment free receiving non steroidal anti inflammatory drugs glucocorticoids demand treated biologic agents differences pediatric adult patients globally analyzed adults tended longer attacks duration presented frequently chest pain headache abdominal pain vomiting cervical adenitis pharyngitis predominated pediatric patients differences outcomes treatment requirements observed age groups conclusion study contributed characterize related disease identifying trends disease phenotypes depending age disease onset
evidence based interventions increase social support potential improve health lesbian gay bisexual transgender queer lgbtq youth hatch youth group level intervention provides services four nights week lgbtq youth years age hatch youth meeting organized three hour sections unstructured social time consciousness raising education youth led peer support group youth attending hatch youth meeting march june completed cross sectional survey covariate adjusted regression models used examine association attendance perceived social support depressive symptomology self esteem coping ability compared attended hatch youth less month participants attended months months reported higher social support beta beta confidence interval respectively increased social support associated decreased depressive symptomology beta increased self esteem beta improved coping ability beta hatch youth promising intervention potential improve mental health reduce risk behavior lgbtq youth
aims intravenous procainamide amiodarone drugs choice well tolerated ventricular tachycardia however choice even according guidelines unclear performed multicentre randomized open labelled study determine safety efficacy intravenous procainamide amiodarone acute treatment tolerated wide qrs complex probably ventricular tachycardia methods results patients randomly assigned receive intravenous procainamide min amiodarone min primary endpoint incidence major predefined cardiac adverse events within min infusion initiation patients included could analysed primary endpoint occurred procainamide amiodarone patients odd ratio confidence interval tachycardia terminated within min procainamide amiodarone patients following adverse events occurred procainamide amiodarone patients among patients structural heart disease primary endpoint less common procainamide patients conclusions study compares first time randomized design intravenous procainamide amiodarone treatment acute episode sustained monomorphic well tolerated probably ventricular tachycardia procainamide therapy associated less major cardiac adverse events higher proportion tachycardia termination within min
functional data analysis become important area research ability handling high dimensional complex data structures however development limited context linear mixed effect models particular small area estimation linear mixed effect models backbone small area estimation article consider area level data fit varying coefficient linear mixed effect model varying coefficients semiparametrically modelled via splines propose method estimating fixed effect parameters consider prediction random effects implemented using standard software measuring prediction uncertainties derive analytical expression mean squared errors propose method estimating mean squared errors procedure illustrated via real data example operating characteristics method judged using finite sample simulation studies
purpose nonverbal communication comprises core element interactions leader follower nevertheless limited empirical attention regarding impact nonverbal cues followers attitudinal outcomes purpose paper contribute gap linking salient form nonverbal communication kinesics researched leader follower relationship outcome relational identification supervisor authors also highlight mediating role leader member exchange lmx aforementioned relationship design methodology approach authors conducted two studies different countries moreover authors examined hypotheses using hierarchical regression bootstrap analysis findings hypothesized present results showed kinesics direct indirect effect lmx supervisor originality value best authors knowledge first study links form nonverbal communication lmx
effect helicobacter pylori colonization stomach patients undergoing laparoscopic sleeve gastrectomy lsg unclear objective study evaluate effect colonization postoperative outcomes lsg setting study university hospital study retrospective cohort study prospectively maintained database patients underwent lsg jordan university hospital five hundred patients included females males mean preoperative weight mean preoperative body mass index bmi two hundred sixteen patients found positive differences positive negative groups respect sex baseline weight bmi statistically significant however patients positive significantly older patients followed least months overall complication rate differences complication rate two groups statistically significant follow year mean percent total weight loss twl mean percent excess weight loss ewl decrease bmi difference two groups statistically significant clear association infection time surgery postoperative complications especially leaks
fatigue subjective unpleasant potentially disabling symptom rooted physiological psychological behavioral causes people living human immunodeficiency virus hiv population highly affected fatigue risk factors associated hiv infection treatment psychosocial disease burden people hiv living longer facing challenge longer disease trajectory palliative nurses expertise symptommanagement play crucial role helping people hiv engage health behaviors prevent mitigate fatigue article authors present definition overview fatigue describe problem fatigue people living hiv present case study illustrates role palliative nurse helping person hiv cope fatigue
background completion advance directives ads power attorney poa documents may protect person autonomy future health care situations individual lacks decisional capacity situations become naturally much common old age specifically aimed providing information frequency ads poa oldest old individuals factors associated completed ads poa methods analyzed data oldest old primary care patients years including community dwelling institutionalized individuals within german agequalide study patients initially recruited via general practitioners gps calculated frequencies ads poa health care confidence intervals used multivariable logistic regression analysis evaluate association ads poa participants socio demographic cognitive functional health related characteristics results among patients participating agequalide response dementia exhausted ill answer questions remaining dementia free patients mean age years stated ads poa health care individual characteristics explain much variability presence absence ads poa regression models nagelkerke frequently stated reasons ads older adults trust relatives physicians make right decisions necessary stated without ads among older adults ads majority received assistance preparation frequently children grandchildren children grandchildren also frequently stated group designated persons poa health care conclusions findings suggest high dissemination ads poa health care oldest old germany adults without ads poa perhaps would completed advance care documents received information support planning programs offer advanced care planning oldest old might helpful respond specific needs also sensitive attitudinal differences target group
study scrim small diameter southern pine bolts treated melamine formaldehyde phenol formaldehyde furfuryl alcohol different loadings formed thick pine scrim lumber psl panels moe mor work maximum load wml internal bond toughness water absorption thickness swelling tangential dynamic swelling termite resistance evaluated results showed samples treated resin highest moe mor wml values gpa mpa respectively whereas treated resin highest edgewise toughness values kpa respectively respect dimensional stability samples treated lowest swelling values submersion water anti swelling efficiency ase lowest water absorption value five hour tangential dynamic swelling test revealed much higher dimensional stability furfurylated samples ase termite resistance untreated treated psl little weight loss high visual rating high mortality laboratory tests impregnation proved feasible modification methods study
tropisetron receptor antagonist commonly prescribed chemotherapy induced nausea vomiting also exhibits high affinity partial agonist activity alpha nicotinic acetylcholine receptors nachrs alpha nachrs considered viable therapeutic targets neuropsychiatric disorders alzheimer disease explored nachr pharmacology tropisetron include homomeric alpha nachr recently characterized heteromeric alpha beta nachr ratio evaluated cognitive effects young aged animals electrophysiological studies human nachrs expressed xenopus oocytes confirmed partial agonist activity tropisetron nachrs similar similar effect alpha beta nachrs similar moreover currents evoked irregular pulses acetylcholine alpha beta nachrs enhanced sustained exposure low concentrations tropisetron indicative priming agonist effect tropisetron improved novel object recognition performance young sprague dawley rats aged fischer rats aged male female rhesus monkeys tropisetron produced increase baseline levels delayed match sample long delay accuracy combination non effective doses donepezil tropisetron produced change accuracy collectively animal experiments indicate tropisetron enhances cognition ability improve effective dose range currently prescribed therapy donepezil moreover effects may explained tropisetron ability sensitize alpha containing nachrs low levels acetylcholine elsevier ltd rights reserved
parents perceptions strategies deal children anxiety minimally explored based mixed method approach current study compared strategies parents said use frequently deal child anxious behaviors strategies actually used two mildly anxiogenic interactions child forty two parents children anxiety disorders aged years participated study semi structured interviews administered identify parental perceptions strategies deal children anxiety subsequently dyadic interactions observed coded two independent coders found discrepancies relating four strategies significantly parents used strategies based overinvolvement anxious behavior interactions reported interviews contrast reassurance reinforcement avoidance dependence used interactions fewer parents would expected according interviews relevant implications assessment intervention families anxious children suggested
objective ventricular rate regularity affect hemodynamic stability targets rate control therapy patients atrial flutter afl atrial fibrillation nevertheless characteristics determinants ventricular response atrial arrhythmias poorly understood work aims investigate effects changes atrial activity atrioventricular conduction patterns ventricular response patients atrial tachyarrhythmias combined quantitative analysis atrial ventricular time series approach time series determined patients episodes afl episodes ventricular response characterized terms mean ventricular interval time domain variability parameters entropy based irregularity measures quadratic entropy rate qse coefficient sample entropy cosen atrial activity characterized terms mean atrial rate variability conduction analyzed synchrogram method quantifying stability coupling average conduction ratio dependence ventricular features atrial determinants investigated correlation analysis main results analysis showed ventricular response display wide spectrum variability irregularity features changing atrial properties ventricular interval significantly correlated conduction ratio spearman correlation coefficient rho correlate atrial rate variability irregularity ventricular response influenced atrial parameters qse cosen significantly increased shorter atrial cycle lengths rho higher atrial variability rho reduced coupling rho smaller conduction ratios rho significance identification determinants ventricular rate regularity may significant implications development efficacious rate control strategies patients atrial tachyarrhythmias
paper presents design development experimental verification active vibration control system aluminum plate active structure consists aluminum rectangular plate host structure strain gages sensor element piezoceramic patch actuation element based characteristics integrated elements use fuzzy optimization strategy based pseudogoal function optimal orientation piezoelectric actuator found whole active vibration control system designed developed active vibration control system controlled proportional integral derivative pid control strategy control algorithm implemented picmxfh microcontroller platform order prevent negative occurrences derivative integral terms pid controller first order low pass filters implemented derivative action feedback integral action experiment considers active damping control periodic excitation experiments conducted verify effectiveness vibration suppression compare damping effect different adjustment pid gains experimental results corresponding developed active vibration control system presented system suppresses vibration amplitude confirms high level effectiveness vibration active damping proposed active structure
facile probing organic solvents attracting intense attention due growing environmental issues herein first time report novel structured methanol responsive fluorescence molecule tto synthesized coupling triphenylamine electron donor toluenesulfonyl electron acceptor via catalytic dipolar cycloaddition click chemistry forming triazole bridge density functional theory dft calculations ray single crystal structure reveal tto highly twisted conformation unique structure render exceptional optical properties tto exhibits strong fluorescence methanol weak fluorescence organic solvents including various alcohols used highly selective fluorescence probe methanol identification notably tto able excellently probe methanol homologue ethanol water detection limit volume concentration demonstrates promise potential tto practical applications elsevier rights reserved
studies third party perceptions intimate partner violence focus heterosexual relationships report male female aggression perceived negatively female male since gender aggressor gender victim consistently confounded portrayals clear whether gender aggressor gender victim accounts effect present research manipulated gender perpetrator victim unravel confound two hundred fifty one participants females read scenarios involving psychological physical aggression two males two females male female participants reported perceptions encounter character emotional reactions individual couple members physical aggression evaluated negatively psychological aggression participants evaluated encounter perpetrator victim manner consistent stereotypical gender roles revealing concern female male victims greater denigration male female perpetrators results implications programs aimed reduction intimate partner violence services programs developed perpetrators victims
background many studies shown victimisation bullies linked psychopathology research also demonstrated forgiveness associated mental health victims bullying method objective explore multiple components forgiveness benevolence decreased avoidance perpetrator diminished desire revenge mediators negative mental health effects bullying italian adolescents hypothesis forgive bullies would show lower levels depression state anger behaviour problems forgive participants students ages two schools southern italy completed five self report questionnaires measuring levels victimisation forgiveness depression anger total behaviour problems results results varied according components forgiveness although benevolence toward victim significant correlate outcome harbouring desire revenge avoiding perpetrator emerged maladaptive conclusions study indicates important working adolescents help victims bullying overcome negative mental health effects victimisation letting forgiveness
paper presents novel surgical instrument integrated four degree freedom dof force sensor adopting capacitive transduction principle sensor enables direct sensing normal shear forces surgical instrument tips thus three dof pulling forces single dof grasping force measured haptic feedback control robotic minimally invasive surgery systems sensor consists four capacitive transducers transducers including analog signal processing units embedded small surgical instrument tips four dof force sensing enabled thanks four capacitive transducers using force transformation method study instrument designed manufactured adaptable open source surgical robot platform called raven addition sensing system experimentally validated application raven using reference force sensor
purpose present investigation assess whether interpersonal closeness facilitates earlier emotion detection emotional expression unfolds female undergraduate participants either paired close friend acquaintance pairs participants viewed morphed movies partner stranger gradually shifting neutral either sad angry happy expression predicted findings indicate closeness advantage close friends detected onset partners angry sad expressions earlier acquaintances additionally close friends accurate acquaintances identifying angry sad expressions onset particularly non vignette conditions expressions void context findings suggest closeness indeed facilitate emotional perception particularly ambiguous situations negative emotions
kingdom saudi arabia ksa witnessed huge increase construction last two decades however many projects experienced time delays cost overruns generation massive amounts waste address challenges lean construction introduced saudi construction industry however still infancy study therefore investigates current state lean construction implementation construction industry ksa objectives identify types construction waste level use tools support implementation lean construction stages application lean methods benefits lean construction achieve objectives structured questionnaire survey construction professionals carried analysis collected data using mean score anova test following conclusions made construction industry ksa waiting common type waste computer aided design cad conventional tool supporting implementation lean construction furthermore data suggests lean construction commonly used construction stage projects customer satisfaction main benefit derived lean construction practices study concludes level implementation lean construction ksa construction industry increasing results help benchmark current state lean construction implementation enable construction industry identify strategies implement lean construction saudi arabia accordance needs project goals achieve better productivity
national survey demonstrated wide disparities services offered sexual assault complainants marked sexual assault referral centres non sexual assault referral centres police victim examination suites national standards introduced expansion sexual assault referral centres aimed evaluate current situation questionnaire based original survey collecting data population covered access funding personnel medical care clinical governance sent sexual assault referral centres open non sexual assault referral centres identified data collected six months december twenty three sexual assault referral centres england scotland responded response rate answered every question access acute referrals although one sexual assault referral centre reported opening always possible due recruitment issues thirteen separate rota often day services offered facilities non police referrals provision anonymous intelligence sexual assault referral centres employed female examiners male examiners half forensic nurse practitioners offered pregnancy testing emergency contraception hiv post exposure prophylaxis hepatitis virus vaccine medical care injuries site follow care provided house counselling sexually transmitted infection screening hepatitis virus vaccination hiv post exposure prophylaxis survey shows improvement services complainants sexual assault since better access forensic examinations medical psychological care however response rate low without data non sexual assault referral centre services give comprehensive national picture results also show little improvement providing sexual health screening site referral addressed sexual assault referral centres
software product lines allow creating set applications share set common features makes software product lines appropriate implementing family software products stakeholder different needs requirements evolve constantly case emergency management firefighters begun using smartphones collaborate access information emergencies however firefighter role requires different information firefighters requirements constantly evolving propose well defined process help stakeholders domain specify products require showing possible apply software engineering process extract collaborative requirements common set applications confirm whether useful real software implementation defined implemented two applications domain paper presents process used systematically define domain model determine domain scope may used domains found process appropriate identifying features related domain collaborative aspects results promising process allowed create two working applications positively received two types stakeholders
study describes image processing systems based artificial neural network estimate tool wear single category based classifier neural network used process tool image data present method determine rate tool wear based image analysis discuss evaluation errors using proposed algorithm made visual basic special neural wear software analysis worn part cutting edge example image worn edge created determining optimum setting neural wear software automatically indicate wear area result analysis number pixels belonged worn area using settings made image analysis edge wear different working times used calculated parameters correlation number pixels index results promise good correlation new methods commonly used optically measured index absolute mean relative error tools entire life range automatic detection wear cutting edge useful many applications example predicting tool life based current value edge wear
design stimulus responsive materials particularly intended respond one stimulus inherently challenging typically trial error process involving multiple synthesis characterization iterations laboratory work latent variable models applied existing failed polymer formulations characterizations facilitate rational design materials specific targeted properties predict responsive polymer properties synthesizing materials laboratory models capable simultaneously predicting three targeted polymer properties cloud point molecular weight recovery polymer mass poly isopropylacrylamide based materials reversibly photo crosslinked model inversion optimization used identify new polymer formulations exhibit significantly improved properties relative formulations developed chemical intuition based available literature model based design approach moves away traditional trial error approach save time energy resources production novel materials time generating responsive polymers improved properties elsevier ltd rights reserved
water cherenkov detector array wcda one core detectors large high altitude air shower observatory lhaaso consists photomultiplier tubes pmts high resolution time charge measurement required large dynamic range photoelectron prototype analogue front end application specific integrated circuit asic fabricated using global foundry cmos technology designed read pmt signal wcda asic employs leading edge discrimination shaping structure combined following time digital converter tdc analog digital converter adc arrival time charge pmt signal measured initial test results indicate time resolution better charge resolution better better large input signals besides asic good channel channel isolation temperature dependency charge measurement less range degrees
internet technology today free many problems security holes security holes could exploited unauthorized person steal important data case attacks occurred party attacked also realize importance network security applied system honeypot system designed resemble original production system made intention attacked compromised research cubieboard implemented using low interaction honeypot decoy attract attackers result research low interaction honeypot implemented embedded system form cubieboard emulates security vulnerabilities directory buster brute force lfi rfi success rate still could emulates sql injection vulnerability one result stress test samples obtained average time deviation sample throughput per minute median stress test conducted threads ramp ups per second
aim study develop hand dynamometer act rehabilitation device acquiring quantified data enhance power hand grip strength whole patient suffers hand injury directly exposed intricacy performing daily task therefore many hand aids developed overcome problem typical hand assistive device able measure hand grip strength eventually increases functionality like hand dynamometer used regular screening hand grip strength also preliminary ongoing assessment patients hand dysfunction trauma strain gauge based system transducer acts measurement system together arduino microcontroller instrumentation communication controlling applications integration strain gauges transducer called load cell also made overall force sensor obtain readings hand grip movement microcontroller use information store analyze data card percentage difference observed hands across sample subjects support rule overall difference found combined dominant non dominant hand strength scores subjects observed
paper develops energy control strategy based multi parametric programming control algorithm parallel hybrid heavy duty truck first based non linear characteristics multiple working modes heavy duty truck set piecewise linear models including longitudinal dynamics engine electric motor established synthesised mixed logical dynamic mld model objective function achieving best fuel economy formulated optimal control law analytically calculated using multi parametric programming algorithm finally simulation hybrid heavy duty truck model conducted uddshdv drive cycle result shows multi parametric programming energy control strategy effectively improve fuel economy compared traditional heavy duty truck simulation model engine
cortical spreading depression csd considered significant phenomenon human neurological conditions one key signatures development persistent cortical oligemia factors underlying reduction cerebral blood flow cbf remain incompletely understood may involve locally elaborated vasoconstricting eicosanoids employed laser doppler flowmetry urethane anesthetized rats together local pharmacological blockade approach test relative contribution cyclooxygenase cox derived prostanoids oligemic response following csd administration non selective cox inhibitor naproxen completely inhibited oligemic response selective inhibition cox preferentially reduced early reduction cbf selective cox inhibition affected later response blocking action thromboxane txa using selective thromboxane synthase inhibitor ozagrel reduced initial cbf decrease inhibition prostaglandin falpha action using selective receptor antagonist blocked later phase oligemia results suggest long lasting oligemia following csd consists least two distinct temporal phases mediated preferential actions cox cox derived prostanoids initial phase mediated cox involves txa followed later phase mediated cox pgfalpha
objective paper identify suitable advance controller among optimized proportional integral derivative pid improved self tuning fuzzy pid istf pid advanced fuzzy nonadaptive pid pid adaptive pid pid controllers speed control nonlinear hybrid electric vehicle hev system conventional pid pid controller tackle nonlinear systems effectively gives poor tracking disturbance rejection performance performances hev proposed advance controllers compared existing pid stf pid conventional fuzzy pid pid controllers proposed controllers designed achieve desired vehicle speed rejection disturbance due road grade reduced pollution fuel economy
paper investigates effects encasement stiffness strength response individual geotextile encased granular columns embedded soft soil model tests similarity analysis first executed determine suitable properties constituents used model tests ensure prototype scale model scale geotextile encased granular columns exhibit comparable behaviour experimental results show encasement improves bearing capability modelled sand columns even encasement rupture occurs marked improvement achieved sand columns encased geotextiles relatively medium high stiffness encasement also restrains radial strain columns significantly predominate bulging encased sand column occurs top depth sand columns encased low stiffness geotextile however sand columns encased relatively high stiffness geotextile exhibit roughly uniform lateral deformation along height column bearing stresses encased columns modelled study agree well values predicted analytical solution using cavity expansion theory elsevier ltd rights reserved
bclb zinc finger type transcription factor regulates development white adipose tissue wat skin central nervous system immune system bclb required proper adipocyte differentiation bclb embryos low amounts subcutaneous wat demonstrated bclb mice lower body weight bclb mice whereas expression adipogenic marker genes wat comparable bclb bclb mice histological analysis indicated bclb mice fed high fat diet much smaller white adipocytes lipid droplets wat liver respectively addition bclb mice increased energy consumption standard high fat diets thus study identifies bclb regulator energy metabolism unlikely bclb functions wat contribute energy metabolism bclb mice
work proposes improved technique design low power bit asynchronous successive approximation register asar analog digital converter adc proposed asar adc consists comparator asar digital control logic block capacitivedigital analog convertor dac comparator preamplier based improved positive feedback latch circuit built sample hold functionality saves enormous amount power implemented digital control logic block performing successive approximation algorithm totally unrestrained external clock pulse outputs comparator given xor logic whose outputs serve internally generated clock ready signal trigger digital control block hence external clock required initiate digital control block making operation asynchronous implementing adc circumvent usage oversampled clock operate single low speed sample clock turn saves power cuts required resilience sampling rates proposed adc designed simulated using umc cmos technology dissipates power operated single power supply achieves complete bit conversion relative accuracy capacitor ratio aperture jitter fom conversion step respectively
background emergency department management hereditary angioedema hae hindered misdiagnosis limited treatment options food drug administration approval demand hae therapies starting publication guidelines angioedema management facilitate improvement hae management objective objective study identify patientreported areas improvement inedmanagement hae attacks methods patients self reported hae inhibitor deficiency attended hae association patient summit asked complete anonymous question survey questions addressed patient characteristics hae management results patients indicated understanding hae needed improvement patients recognition hae diagnosis patients appreciation hae serious disease patients medication management patients identified areas needing improvement among patients required care within last year receive hae targeted therapy treatment corticosteroids epinephrine antihistamines reported among patients whose treatment plan receive home demand therapy required care inability receive demand therapy home outlined treatment plan treatment plan associated greater likelihood receiving hae therapy conclusion hae management improved focus recognition hae attacks administration effective hae therapies american academy allergy asthma immunology
investigation paper inhomogeneous modified nonlinear schrdinger mnls equation describing ultrashort pulse dynamics distributed dispersion self phase modulation self steepening linear gain loss nonautonomous rogue waves inhomogeneous mnls equation constructed via modified darboux transformation inhomogeneous parameters dynamical behaviours main characteristics nonautonomous rogue waves inhomogeneous fibers discussed analysing certain physical quantities inhomogeneous effects evolution rogue waves considered virtue presented rational solutions distributed coefficients found group velocity dispersion gvd linear gain loss coefficients effects trajectories amplitudes rogue waves respectively additionally intriguing composite rogue wave inhomogeneous mnls equation revealed owing proper choice gvd coefficient results could useful controlling rogue waves dispersion managed fiber system
objectivesto determine extent agreement four commonly used definitions multiple chronic conditions mccs compare definition ability predict day hospital readmissions designretrospective cohort study settingnational medicare claims data participantsrandom sample medicare beneficiaries discharged hospital measurementsbaseline chronic conditions determined participant using four definitions mcc primary outcome cause day hospital readmission agreement mcc definitions measured sensitivities specificities definition ability identify patients experiencing future readmission calculated logistic regression used assess ability mcc definition predict day hospital readmission resultsthe sample prevalence hospitalized medicare beneficiaries two chronic conditions ranged johns hopkins adjusted clinical groups acg case mix system software medicare chronic condition warehouse ccw slight moderate agreement kappa pair wise combinations mcc definitions ccw defined mcc sensitive sensitivity specificity acg defined mcc specific sensitivity specificity predictor readmitted fully adjusted model risk readmission higher chronic condition special needs plan snp defined mccs odds ratio confidence interval charlson comorbidity index defined mccs acg defined mccs ccw defined mccs without mccs conclusionmcc definitions demonstrate poor agreement used interchangeably two definitions greatest agreement cci snp also best predictors day hospital readmissions
survey adolescents documented third person perception regarding media depictions dating relationship violence also contributes growing literature documenting optimistic bias strong predictor third person perception draws optimistic bias literature considering new variables including self esteem self efficacy experience violence
positive attributes prevalent negative attributes social environment basic assumption implications overlooked thus far positive compared negative attributes likely shared individuals people shared attributes similarities positive unshared attributes differences consequently similarity based comparisons lead positive evaluations difference based comparisons formalized probabilistic reasoning model tested predictions simulation experiments participants generated traits target persons positive compared negative traits likely shared targets experiment participants targets experiment conversely searching targets shared traits resulted positive traits searching unshared traits experiments addition positive traits accessible negative traits among shared traits among unshared traits experiment finally shared traits positive positive traits indeed prevalent experiments current framework number implications comparison processes provides new interpretation well known evaluative asymmetries intergroup bias self superiority effects
geopolymers three dimensional aluminosilicates formed short time low temperature geopolymerization paper alkali activated foam geopolymers fabricated circulating fluidized bed fly ash cfa effect sio nao mole ratio properties studied geopolymerization products characterized mechanical testing scanning electron microscopy sem energy dispersive ray spectroscopy edx ray diffraction xrd results show sio nao mole ratio plays important role mechanical morphological characteristics geopolymers foam samples prepared sio nao mole ratio exhibit greatest compressive strength mpa morphological analysis reveals foam geopolymers appear relatively optimized pore structure distribution beneficial structure stability moreover combination atomic ratio ranging atomic ratio produces samples high strength
paper presents newest potential developments artificial intelligent technologies welding manufacturing process shanghai mao tong university sjtu contains multi information acquirement fusion processing arc welding dynamical process intelligent computing welding process intelligent control methods welding process quality control artificial intelligent technologies welding robot systems robotic welding process application welding engineering ideas intelligentized welding manufacturing technology iwmt intelligentized welding manufacturing engineering iwme presented paper systematization intending researches applications intelligentized technologies modem welding manufacturing
geotextile tube type geocontainer typically filled sandy slurries fine grained dredged sediments performance strength dewatering fine particle retention stacked stability studied extensively however little understood shape deformation behavior geotextile tubes paper slurry settlement constant head permeability seepage force tests conducted determine geocontainers geotechnical design parameters characteristics dredged fill material determined slurry settlement constant head permeability seepage force tests presented large scale tests model geotextile tubes also conducted large scale apparatus geotextile tube filling test simulation introduced apparatus consists slurry mixing station pumping delivery station geotextile tube filling station data station results model tests conducted transparent geobag undrained condition geotextile tube drained condition presented paper
background recent studies suggested interactions among several factors affect onset progression prognosis major depressive disorder study investigated childhood abuse neuroticism adult stressful life events interact one another affect depressive symptoms general adult population subjects methods total participants nonclinical general adult population completed patient health questionnaire child abuse trauma scale neuroticism subscale shortened eysenck personality questionnaire revised life experiences survey self report scales structural equation modeling mplus version single multiple regressions used analyze data results childhood abuse neuroticism negative evaluation life events increased severity depressive symptoms directly childhood abuse also indirectly increased negative appraisal life events severity depressive symptoms enhanced neuroticism structural equation modeling limitations recall bias study causal relationship clear study conducted using cross sectional design conclusion study suggested neuroticism mediating factor two effects childhood abuse adulthood depressive symptoms negative evaluation life events childhood abuse directly indirectly predicted severity depressive symptoms
current approaches dutch mental health care institutions towards inpatients aggression focused predominantly environmental factors training staff aggression management however personality traits might important factor patients aggression shown incidents wards study explores influence dysfunctional impulsivity alexithymia psychiatric patients aggressive behavior self reports involvement aggressive incidents personality traits influencing patients aggression emphasize importance direct approach aggression clinical patients dutch mental health care institution emergis filled questionnaires aggressiveness using buss perry aggression questionnaire short form dysfunctional impulsivity alexithymia multiple regression analyses indicated dysfunctional impulsivity positively related self reported aggressive behavior relationship however could confirmed inpatients aggression reported staff wards unexpectedly affective alexithymia negatively related hostility gender differences self reported aggression found female patients showed higher levels hostility regression analyses indicated male gender positively related physical aggression findings emphasize importance new approach dutch mental health care patients may engage aggression regulation training programs elsevier ireland ltd rights reserved
background calciphylaxis serious complication patients chronic kidney disease associated mineral bone disorder occur conditions low high bone turnover far definite diagnostic therapeutic guidelines may prevent devastating outcome many calciphylaxis patients report case clearly illustrates knowledge underlying bone disorder essential directed treatment based experience discuss systematic diagnostic therapeutic approach patients calciphylaxis case presentation report patient severe calciphylaxis initial evaluation showed elevated serum parathormone concentration bone specific alkaline phosphatase activity upper normal range however bone biopsy clearly showed adynamic bone disease extended dialysis low calcium dialysate concentration citrate anticoagulation administration teriparatide led increase bone specific alkaline phosphatase activity importantly resulted activated bone turnover confirmed second bone biopsy weeks later conclusions case illustrates laboratory tests reliably differentiate high low bone turnover calciphylaxis patients importantly case highlights fact specific therapies alter bone metabolism applied without knowledge bone status background suggest bone biopsies integral part diagnosis therapeutic decision patients evaluated studies
approximately three million individuals united states chronically infected hepatitis virus hcv chronic hcv infection may lead development compensated well decompensated liver cirrhosis phase impact study conducted hcv genotype infected cirrhotic patients portal hypertension decompensated liver disease assessed first time combination three direct acting antivirals simeprevir daclatasvir sofosbuvir treatment naive treatment experienced adults child pugh score evidence portal hypertension score received weeks simeprevir daclatasvir sofosbuvir daily primary efficacy endpoint sustained virologic response weeks end treatment svr pharmacokinetics safety also assessed overall patients enrolled patients achieved svr week mean pharmacokinetic exposure simeprevir sofosbuvir daclatasvir sofosbuvir metabolite fold higher patients respectively grade adverse events aes occurred patients one patient grade gastrointestinal haemorrhage reported serious considered related study drugs treatment weeks simeprevir daclatasvir sofosbuvir generally safe well tolerated resulted cirrhotic patients portal hypertension decompensated liver disease achieving svr
generalized state space representation dynamical systems random modes switching according white random process presented new formulation includes term dynamics equation depends recent linear minimum mean squared error lmmse estimate state model behavior feedback control system featuring state estimator measurement equation allowed depend previous lmmse estimate state represent fact measurements obtained validation window centered predicted measurement entire surveillance region lmmse filter derived considered problem approach demonstrated context target tracking clutter shown competitive several popular nonlinear methods
review comparative analyses methods restricting range molecular interactions within concept atom atom potentials presented emphasis placed problem calculating electrostatic energy models periodic boundary conditions numerous calculations thermodynamic structural characteristics water using parallel monte carlo computations shown use functional forms simulating electric potentials screened charges provides good results
article addresses measurement assessment response times error rates map reading tasks relative various modes linear feature visualization subject design study participants completed set map reading tasks generated approaches traffic problem entailed quick correct decoding graphically represented quantitative qualitative spatial information tasks first involved decoding one graphic variable two variables simultaneously alternative representations qualitative information included colour hue symbol shape quantitative information communicated either symbol size colour value bivariate tasks quantitative qualitative graphical elements combined single display individual differences also examined concept cognitive style partially explains variability people perception thinking describing individual preferences object representation problem solving strategies data obtained experiment suggest alternative forms visualization may different impacts performance map reading tasks colour hue size proved efficient communicating information shape colour value apart shown individual facets cognitive style may affect task performance depending type visualization employed
eating disorders obesity become predominant human society association modern lifestyle encompassing calorie rich diets psychological stress comorbidity major diseases well documented unfortunately biological basis remains elusive pharmacological treatment inadequate part due limited availability valid animal models human research binge eating disorder bed proves strong link stress exposure bingeing state levels stress negative affect linked binge eating individuals bed laboratory settings natural environment similarly classical animal models bed reveal association acute exposure stressors binging often associated unchanged decreased body weight thus reflecting negative energy balance uncommon humans commonly bed associated excessive unstable body weight gain recent mouse models subordination stress induce spontaneous binging hyperphagia altogether closely mimicking behavioral metabolic features human bed therefore translational relevance subordination stress models could facilitate identification neurobiological basis bed obesity associated disease inform development innovative therapies elsevier ltd rights reserved
infancy children later receive diagnosis autism spectrum disorder asd show impairments eye gaze within joint attention requesting contexts notably initiating interactions impairments correlate later social communication play development adequately address social communication impairments characterize asd early intervention must address areas examined brief social communication intervention teaching eye gaze select social communication contexts examining generalization initiating joint attention interactions participants mothers three toddlers asd participated intervention involving prompting prompt fading reinforcement two toddlers showed generalization requesting joint attention interventionist three showed generalization interactions mothers semi structured play interaction findings discussed terms generalization efficiency intervention
background considerable claims made benefits interprofessional learning ipl despite limited evidence long term effectiveness collaboration australian national university university south australia offered opportunities senior health professional students undertake ipl teamwork placements rural nsw health hubs spokes project aim study evaluate using mixed methods outcomes ipl project four levels freeth kirkpatrick evaluation model methods students completed debriefing questionnaire interprofessional education perception scale ieps team performance scale tps time undertook ipl placements follow study measured anticipated professional networks extent interprofessional experience ipl facilitators clinical supervisors local health service representatives asked provide views perceived project outcomes results initial evaluation demonstrated positive student reaction level attitude change collaborative skills level follow study failed show significant changes size expected professional networks qualitative exploration transfer learning professional practice level impact ipl placements rural locations level suggest positive impact participants healthcare delivery conclusion project generated student satisfaction changes attitude skills longer term positive impacts community possibly students professional practice evaluation model used effectively evaluate outcomes ipl teamwork placements rural settings potentially locations
article analyzes interconnections migration masculinity vida emigrante espanol victor canicio novel based true events tells story working class man called pedro nuno displays traditional conception masculinity based importance heteronormative home procreation sacrifice family pedro decides migrate germany achieve better future family feel respected man earning money accomplishing economic independence way migration enhances sense masculinity hand novel also shows migration may negatively affect men traditional ideas masculinity pedro male characters feel discriminated exploited jobs lose libidos experience insecurity nostalgia insanity finally another consequence migration slight change main character conception gender roles since ends supporting egalitarian relationship wife
objectives study effect angulation left pulmonary artery lpa main pulmonary artery pulmonary haemodynamics methods model patient specific pulmonary artery reconstructed original model four models descendent lpa angulation equalled degrees degrees degrees degrees reconstructed computer aided design virtual simulation pulmonary flow different surgical strategies computational fluid dynamics introduced calculate pulmonary blood flow five models streamlines wall shear stress energy loss flow distribution ratio calculated compared determine better haemodynamics pulmonary artery results vortices formed lower wall opening right lpa models lpa angles equal less degrees models relative high wall shear stress areas lateral lower wall lpa opening ascendant tendency angle declined decreased flow distribution ratio left lung original model model model model model increased energy loss original model model model model model cardiac cycle noted angle reduced conclusions acute lpa angulation associated adverse haemodynamic performance particularly addressed reconstruction pulmonary artery repair tetralogy fallot
background spatial normalization brain images prerequisite voxel based morphometry analysis may account large variability volumetric data medication overuse headache moh possibly disease concerns patients differing sex age hence different brain size shape methods present study aimed providing subject based analysis macrostructure using native space volumes segmentation freesurfer microstructure using region interest roi hippocampus tractography approach moh patients results results show moh patients decreased volumes left hemisphere temporal gyri temporal superior fusiform occipital middle gyrus together increased volume left inferior temporal lateral ventricle left temporal volume negatively correlated depression score medication dependence parameters seed based tractography hippocampus revealed decreased number reconstructed fibers passing left hippocampus conclusion knowledge alterations described methods involving brain normalization indicate left hemisphere temporal areas including hippocampus may play role moh pathophysiology
objectives study evaluated contributions obesity changes body mass index bmi mid life long term heart failure risk independent cardiorespiratory fitness crf levels background obesity low crf well established risk factors however given inverse association crf obesity independent contributions bmi toward risk fully understood methods included participants cooper center longitudinal study survived receive medicare coverage crf estimated metabolic equivalents mets according balke treadmill time associations bmi bmi change hospitalization age assessed applying proportional hazards recurrent events model failure time data results person years follow observed hospitalization events higher mid life bmi significantly associated greater risk hospitalization adjusting established risk factors hazard ratio confidence interval per higher bmi association attenuated adjusting crf per higher bmi crf accounted risk associated bmi bmi change significantly associated risk older age adjustment crf change conclusions higher bmi associated risk explained largely differences crf levels furthermore bmi change significantly associated risk adjusting crf changes findings highlight importance crf mediating bmi associated risk coll cardiol american college cardiology foundation
applying attachment theoretical perspective study examined relationship pattern childhood parenting experience adulthood depression mediated anger control data based national comorbidity study replication participants met dsm criteria lifetime major depressive disorder participants reported perceived anger control mediation hypothesis tested logistic regression models results showed childhood parenting experience significantly related major depressive disorder anger control significant indirect effect anger control detected bootstrap analysis supporting partial mediation hypothesis study represents first attempt examine mediating role anger control relationship early parenting depressive disorder findings study suggest early parenting experience may important factor consideration research aiming understand sequential relationship anger control depression
paper presents effective way enhance secret key guessing ratio machine learning based power analysis attack secure systems smartcards power supply current traces obtained varying atmospheric temperature possible values key collected power supply current traces pre processed using wavelet transform data normalization principal component analysis pca featured data samples used train probabilistic neural network pnn network tested current trace obtained device attack correct key identified proposed method achieves success rate guessing secret key cryptographic algorithm minimum number power traces compared existing methods machine learning technique
paper novel approach web based education performs individualized instruction domain programming languages presented approach fully implemented evaluated educational application module called fuzzy knowledge state definer fuzksd particular fuzksd performs user modeling dynamically identifying updating student knowledge level concepts domain knowledge operation fuzksd based fuzzy cognitive maps fcms used represent dependences among domain concepts fuzksd uses fuzzy sets represent student knowledge level subset domain knowledge thus combines fuzzy theory overlay model moreover employs novel inference mechanism dynamically updates user stereotypes using fuzzy sets noted overlay model stereotypes constitute two widely used methods user modeling however combined fuzzy sets thus far literature gain novel combination significant student level knowledge represented realistic way automatically modeling learning forgetting process student respect fcms thus system provide individualized adaptive advice application approach limited adaptive instruction also used systems changeable user states shops consumers preferences change time affect one another therefore particular module constitutes novel generic fuzzy tool offers dynamic adaptation users needs preferences adaptive systems
paper studied associations volatile organic compounds voc formaldehyde nitrogen dioxide carbon dioxide schools malaysia rhinitis ocular nasal dermal symptoms headache fatigue among students pupils eight randomly selected junior high schools johor bahru malaysia participated voc formaldehyde measured diffusion sampling one week voc also pumped air sampling class associations calculated bymulti level logistic regression adjusting personal factors home environment microbial compounds school dust prevalence weekly rhinitis ocular throat dermal symptoms respectively totally weekly headache fatigue indoor low range ppm indoor median formaldehyde concentrations one week respectively median indoor concentration toluene ethylbenzene xylene limonene one week respectively benzaldehyde mean indoor concentration median median indoor levels class benzene cyclohexane respectively associated ocular symptoms fatigue formaldehyde associated ocular throat symptoms fatigue xylene associated fatigue benzaldehyde associatedwith headache conclusion xylene benzaldehyde formaldehyde schools risk factors ocular throat symptoms fatigue among students malaysia indoor outdoor levels benzene often higher standard published elsevier
aim study investigate impact statins therapy morphological changes lipid rich plaques oct optical coherence tomography patients known chd coronary heart disease stratified frs ninety seven lipid rich plaques sixty nine patients received statins therapy underwent serial oct images baseline month month divided groups according frs framingham risk score low risk group frs fibrous cap thickness fct measured thinnest part times baseline characteristics different groups fct sustained increased baseline month month follow group respectively group respectively lipid index significantly decreased group group incidence tcfa decreased statistically group group patients known chd equivalently benefit statins therapy stabilizing lipid rich plaques patients moderate high frs might benefit within first year event time
objective assess observational data low testosterone men independent risk factor high fasting glucose diagnosis type diabetes methods multivariate analysis data male air force veterans completed six medical examinations years results low testosterone moderately related high independent age obesity low testosterone weak predictor diagnosis conclusions men low testosterone independent risk factor high comparable aging obesity low testosterone weak predictor diagnosis
paper presents observational study conducted public environment investigating children engagement social robot within pretend play scenario pretend play system designed order address challenges evaluating child robot interaction exploiting advantages ubiquitous robotics ambient intelligence multimodal multi sensory perception system performed successfully children play centre humanoid nao robot able dynamically adapt gender changing gendered voice match gender child analyzing free play children results obtained confirm hypothesis gender segregation within child robot interaction findings important ought considered designing robotic applications children order increase robot perceived likeability acceptance engagement
report unusual combination anomalies head female fetus authors examined whole body semiserial paraffin sections female fetus crl similar weeks gestation particular focus head region cranial autonomic ganglia nasal olfactory cells orbital muscle investigated using immunohistochemistry tyrosine hydroxylase vasoactive intestinal peptide calretinin smooth muscle actin expression surface gross anatomy fetus appeared normal left eyeball lacked lens eyeballs otherwise normal orbital muscle thick located anterolateral side extraocular muscles conversely extraocular muscles made cluster superoposterior side orbit infratemporal fossa small due bulky transversely extended lateral pterygoid process contrast small coronoid process mandible bilateral mandibular bases overlapped midline symphysis thin orbitosphenoid thick alisphenoid provided almost flat anterior cranial base nasal olfactory cells cranial autonomic ganglia appeared normal major anomaly observed brain changes topographical anatomy orbital muscle probably lost normal bony attachment appeared push extraocular muscles superoposteriorly gene function redundancy rather mutation may explain present restricted anomalies mandible pterygoid process clin anat wiley liss inc
megson comish defined techniques using systematic approach derive parallel algorithm riccati type equations paper techniques used derive full three dimensional hierarchical signal flow graph hsfg square root covariance kalman filter srckf algorithm novel flow graph involves matrix matrix multiplication givens rotations schur complement algorithms simple projection techniques detailed megson rajopadhye fujimoto used form two dimensional descriptions algorithm parallel algorithms srckf generated using algorithm engineering techniques extended example algorithm engineering techniques given megson parallel algorithms form systolic architectures proposed gaston brown gaston derived detail
associative memory refers remembering association two items face name crucial part daily life also one first aspects memory performance impacted aging alzheimer disease evidence suggests transcranial direct current stimulation tdcs improve memory performance tdcs studies investigated impact associative memory addition prior study effects tdcs memory performance systematically evaluated impact tdcs different types memory assessments recognition recall tests study measured effects tdcs associative memory performance healthy adults using recognition recall tests participants studied face name pairs receiving either active min sham min stimulation anode placed cathode placed contralateral upper arm participants active stimulation group performed significantly better recall test participants sham group recalling names average making fewer recall errors however two groups differ significantly terms performance recognition memory test investigation provides evidence stimulation time study improves associative memory encoding memory benefit evident certain retrieval conditions elsevier rights reserved
introduction paucity research psychiatric problems associated early stage hiv clinical disease sub saharan africa methods cross sectional study undertaken among adult art nave persons early stage hiv clinical disease participants clinical stage attending semi urban rural clinic uganda results prevalence major depressive disorder study moderate high risk suicidality multivariable analyses found factors socio demographic vulnerability protective stress major depressive disorder domains significantly associated major depressive disorder moderate high risk suicidality major depressive disorder moderate high risk suicidality significantly associated impaired psychosocial functioning greater utilisation health services non adherence septrin dasone neither major depressive disorder moderate high risk suicidality associated counts risky sexual behaviour non utilisation condoms limitations bidirectional nature relationships investigated psychiatric problems risk factors outcomes cross sectional study makes difficult elucidate actual direction causality conclusion early stage hiv clinical disease associated considerable major depressive disorder moderate high risk suicidality therefore need integrate mental health hiv interventions target early stage hiv disease
response generally sympathetic agrees many aili tripp points raise couple issues divert somewhat different example unlike way tripp essay emphasizes geographical cultural differences comparative framework propose political aim particular feminist activism acts primary reason certain feminist political projects emphasize similarity others differences among women also discuss respect transversal politics women groupings cooperate across borders boundaries recognizing different social locations identifications sharing common feminist emancipatory political perspectives working dialogical epistemology transversal politics activists however see representing women even women collectivity rather advocates case danger essentialist construction womanhood gender roles measures like resolution calls increase number women women participants peace negotiations mandatory double edge sword women seen promoters peace
study synthesized series nitrophenyl aryl dihydropyrimidin thio propanenitriles structures characterized spectral nmr nmr infrared spectroscopy liquid chromatography mass spectroscopy elemental analysis antimicrobial activity carried serial broth dilution method gram positive bacteria staphylococcus aureus streptococcus pyogenes gram negative bacteria escherichia coli pseudomonas aeruginosa three fungi candida albicans aspergillus niger aspergillus clavatus vitro compounds showed potent antimicrobial activity tested microorganisms grades cytotoxicity studies human cervical cancer cell line hela mouse embryonic fibroblast cell line indicated compounds showed low cytotoxicity
accurate scale estimation occlusion handling challenging problem visual tracking recently correlation filter based trackers shown impressive results terms accuracy robustness speed however model robust scale variation occlusion paper address problems associated scale variation occlusion employing scale space filter multi block scheme based kernelized correlation filter kcf tracker furthermore develop robust algorithm using appearance update model approximates change state occlusion deformation particular adaptive update scheme presented make process robust experimental results demonstrate proposed method outperformed state art trackers challenging sequences specifically results obtained proposed scheme improved compared kcf tracker occlusion scale variation sequences respectively therefore proposed tracker robust useful tool object tracking occlusion scale variation involved
acrolein highly toxic volatile unsaturated aldehyde generated incomplete combustion tobacco smoke indoor fires transient receptor potential ankyrin trpa channel mediates tobacco smoke induced lung injury assessed role high level acrolein induced toxicity mice acrolein ppm min caused upper airway epithelial sloughing bradypnea oral gasping hypothermia cardiac depression mortality male wild type mice cbl weeks significantly sensitive high level acrolein age matched female mice male female trpai null mice sensitive acrolein induced mortality age sex matched mice acrolein exposure increased lung weight body weight ratios lung albumin decreased plasma albumin greater extent trpa null mice lung plasma protein acrolein adducts increased acrolein exposed trpal null mice compared mice assess trpa dependent protective mechanisms respiratory parameters monitored telemetry trpa null mice slower onset breathing rate suppression respiratory braking mice suggesting trpai mediates protective response surprisingly male mice treated either trpai antagonist alone combined trpa trpv capsazepine antagonists min post acrolein exposure real world delay treatment significantly protected acrolein induced mortality data show trpa protects high level acrolein induced toxicity sex dependent manner post exposure trpa antagonism also protected acrolein induced mortality attesting complex role trpa cardiopulmonary injury elsevier inc rights reserved
two dimensional electronics based single layer mos offers significant advantages realizing large scale flexible systems owing ultrathin nature good transport properties stable crystalline structure work utilize gate first process technology fabrication highly uniform enhancement mode fets large mobility excellent subthreshold swing enable large scale mos circuit also develop verilog compact models accurately predict performance fabricated mos fets well parametrized layout cell fet facilitate design layout process using computer aided design cad tools using cad flow designed combinational logic gates sequential circuits nand xnor latch edge triggered register well switched capacitor converter fabricated using proposed flow showing excellent performance fabricated integrated circuits constitute basis standard cell digital library crucial electronic circuit design using hardware description languages proposed design flow provides platform optimization device fabrication technology circuits design future ubiquitous flexible transparent electronics using two dimensional materials
purpose review review aims give update literature around traffic related air pollution trap allergic disease context global urbanization populous countries world face severe trap exposure challenges recent findings research continues show gene environment interactions epigenetics contribute trap allergy link evidence around links climate change grows greenspace may provide buffer adverse effects traffic health overall pose risks terms allergic disease summary link traffic related pollution allergy continues strengthen terms supportive observational findings mechanistic studies levels trap across world particularly asia continue dramatically exceed acceptable levels suggesting related adverse health consequences accelerate could counterbalanced primary emission control urban planning attention combined effects trap allergen exposure critical avoiding misleading inferences drawn though examination isolated factors
new renewable energy drawing attention fossil fuels depleted solar cell type new renewable energy produce energy daytime contaminants attached onto surface solar cells module following yellow dust dust bird droppings low efficiency solar cells caused reducing solar energy contaminants thus important remove contaminants attached surface solar cell modules study surface properties glass substrate coated functional nano thin films analyzed oven microwave oven natural drying conditions
muscle ligament injuries among common sports injuries anterior cruciate ligament acl injuries commonplace many sporting codes several studies performed effort quantify loading cruciate ligaments activity however ultimately rely data obtained static machines performing isokinetic movements smart compression garments scg functioning wearable muscle ligament management system developed understand loading ligaments whilst providing additional means mitigate risk overload strain forces determined new method calculating cruciate ligament forces utilising forward dynamic calculation scg determined muscle forces knee angle four controlled scenarios performed evaluate ligament loading conditions involving maximal contraction hamstrings quadriceps several knee flexion angles loading cruciate ligaments demonstrated walking treadmill acl pcl significantly stressed alternatively per stride application scg allows associated information processing soft tissue data wearable system capable assessing active muscle load cruciate ligament forces contraction paired muscles real time providing metrics improved performance safety authors published elsevier ltd
objective investigate clinical value serum lung diseases patients polymyositis dermatomyositis methods cases patients among cases interstitial lung disease ild cases infectious lung disease cases without lung disease elisa method adopted measure levels serum association diagnosis clinical features laboratory indexes treatment even prognosis analyzed results average values levels serum patients ild patients infectious lung disease patients without lung diseases respectively patients ild significantly higher median levels serum compared two groups difference statistically significant difference patients infectious lung disease patients without lung disease statistical significance regarded positive standard sensitivity interstitial lung disease diagnosis specificity serum levels inversely correlated dlco tlv serum increased group anti positive rate higher normal group follow analysis indicated levels serum cases ild patients associated therapeutic effect levels serum cases died ild patients significantly higher cases ild patients surviving conclusion levels serum used identify interstitial lung disease infectious lung disease assess clinical response treatment high level possibly indicates poor prognosis
algebraic relationship transfer function state space representations linear active disturbance rejection control ladrc derived upon unique frequency response characteristics ladrc seen understood transfer function form ladrc arbitrary order plant derived state space representation allows open loop frequency characteristics ladrc based control system conveniently obtained analyzed frequency response ladrc shows excellent loop gain shape also validates original adrc design concept internal external disturbances estimated real time cancelled time evidence comes simulation test time domain analysis language practicing engineers frequency response
background serum uric acid shown predictor renal disease progression studies study aims test whether renal function normalized serum uric acid superior serum uric acid predictor incident chronic kidney disease type diabetes mellitus patients methods study type diabetes mellitus patients estimated glomerular filtration rateml min normouricemia included renal function normalized serum uric acid calculated using serum uric acid creatinine cox regression analysis used estimate association serum uric acid renal function normalized serum uric acid incident chronic kidney disease results total patients developed chronic kidney disease greater median follow years older ages longer diabetes duration lower estimated glomerular filtration rate baseline decline rate estimated glomerular filtration rate positively correlated serum uric acid creatinine serum uric acid moreover multivariate analysis revealed serum uric acid independent risk factor incident chronic kidney disease whereas serum uric acid creatinine ratio significantly associated incident chronic kidney disease independently potential confounders including baseline estimated glomerular filtration rate conclusion serum uric acid creatinine ratio might better predictor incident chronic kidney disease type diabetes mellitus patients
nowadays continuous demand motors high efficiency good dynamic performances transient regimes reduced overall dimensions optimized wheel brushless motor design technique proposed design algorithm developed two distinct software packages mathcad matlab new generation materials considered design process motor become alternative competitive producers example provided motor used driving mini scooter motor good efficiency preserving reduced dimensions competitive cost
background depression major public health challenge worldwide polyunsaturated fatty acids pufas especially pufas found inversely associate risk depression however cross sectional studies investigated association dihomo linolenic acid dgla pufa anti inflammatory effects depression aims present study examine association serum dgla risk depression study whether potential association mediated via inflammation methods year prospective kuopio ischaemic heart disease risk factor kihd follow study conducted middle aged older finnish men years old baseline baseline concentrations serum fatty acids including dgla determined hospital discharge diagnosis depression used main outcome obtained linkage national hospital discharge register serum reactive protein crp levels measured assess inflammation results inverse association serum dgla concentration incidence depression found adjustment several potential confounders hazard ratio association dgla depression dependent inflammation interaction limitations findings may generalizable individuals middle age women moreover unable consider cases mild depression longitudinal setting conclusions higher serum dgla concentrations may predict lower risk develop depression elderly men studies warranted address potential mechanisms mechanism behind association remains unclear
gamification become focus attention increasing number fields including business education health care wide range applications support functions potential tourism industry significant gamification tourism contribute rewarding interactions higher level satisfaction well increase brand awareness loyalty destination one first attempts conceptualize gamification tourism paper examines gaming general terms application specific tourism fields identifies game design elements contribute meaningful gamification cases best practices presented show innovative concept benefit tourism marketing implications tourism marketing management discussed well future research recommendations elsevier ltd rights reserved
background lack treatment plurality step improving access psychological therapies iapt services project therefore sought develop pilot cognitive analytic informed guided self help treatment mild moderate anxiety delivery psychological wellbeing practitioners pwps method medical research council treatment development guidelines used phase included development six session treatment manual using practice guidelines small scale modelling indicated manual iterations phase consisted mixed methods case series design index feasibility uptake clinical outcomes results cognitive analytic guided self help cat met established quality parameters guided self help high treatment completion rate observed patients attended first treatment session subsequently completing full treatment six ten patients completing full treatment met reliable recovery criteria follow effect sizes recovery rates equate extant pwp outcome benchmarks practitioner feedback indicated delivery cat feasible conclusion cat shows promise low intensity treatment anxiety larger controlled evaluations indicated
present simple method describe geometry topologically classify intersection level sets trilinear interpolants reference unit cell solutions three quadratic equations used correctly triangulate level set within cell satisfying conditions imposed asymptotic decider way triangulation isosurfaces across cells borders manifold topologically correct algorithm presented intuitive easy implement
background obesity increases risk knee hip joint implantation negatively contributes wound healing study patients undergoing hip knee arthroplasty amount peripheral immune effector cells pre post operative well expression certain soluble factors affecting functions immune effector cells investigated methods peripheral immune cells expression soluble factors determined flow cytometry correlated dependency bmi sex kind arthroplasty results pre operative amounts peripheral cells cytotoxic cells significantly decreased increasing bmi furthermore expression immunomodulatory adipokine leptin nicely correlated bmi effects stronger males females furthermore correlation activation marker stnf peripheral cells strongly decreased increasing bmi cdl mpo significantly induced surgery correlations bmi conclusions known wound healing problems obese patients osteoarthritis per linked bmi obese patients exerted reduced peripheral cells cytotoxic cells ctls showed involvement however adipokine leptin strongly increased bmi strengthening role immunomodulatory molecule negatively interfering functions immune effector cells
paper starts basic process music recognition complete study extraction realization seven musical characteristics music features characterization time paper depth studies pitch value duration tonality characteristic extraction unit fourier analysis method based short time uses computer programming audio signal automatic analysis processing implements characteristics recognition piano music playing experimental data show average recognition rate algorithm strong recognition ability provides core technology support developing evaluation system piano performance
wireless body area network wban provide mechanism transmitting persons physiological data application providers hospital given limited range connectivity associated wban intermediate portable device smartphone placed within wban connectivity forwards data remote server data protected unauthorized access modification may lead poor diagnosis order ensure security privacy wban server application provider several authentication schemes proposed recently wang zhang proposed authentication scheme wban using bilinear pairing however scheme application provider could easily impersonate client order overcome weakness propose efficient remote authentication scheme wban terms performance scheme provide malicious insider security also reduce running time wban client compared wang zhang scheme
nature quality social work decision making highlighted recent years number high profile child deaths recognising assessing child abuse beset uncertainties complexities profoundly shape practice yet often overlooked official distanced accounts paper draws ethnographic data study social workers decision making uncover issues faced gathering assessing information workers faced problems inaccurate incomplete information poorly defined situations time pressures heavy workloads paper draws attention ways team organised manage issues could provide better understanding everyday decision making supported improved
hemodynamic energy loss surgically implanted conduits determines postoperative cardiac output exercise capacity following palliative repair single ventricle congenital heart defects study hemodynamics severely deformed surgical pathways due torsional deformation anastomosis offset investigated designed mock total cavopulmonary connection tcpc circuit replicate mechanically failed inferior vena cava ivc anastomosis morphologies physiological venous pressure mmhg vitro employing commonly used conduit materials polytetrafluoroethylene ptfe dacron porcine pericardium sensitivity hemodynamic performance torsional deformation three different twist angles deg deg deg three different caval offsets diameter digitized three dimensions employed computational fluid dynamic cfd simulations determine corresponding hydrodynamic efficiency levels total deformed conduit configurations analyzed pressure drop values increased respect ideal uniform diameter ivc conduit flow investigated surgical materials resulted significant variations terms flow separation energy loss example porcine pericardium resulted pressure drop eight times greater dacron conduit likewise ptfe conduit resulted pressure drop three times greater dacron conduit venous pressure loading anastomosis twist caval offset avoided intraoperatively due anatomy patient alternative conduit materials high structural stiffness less influence hemodynamics considered
present overview ovarian cancer epidemiology summarizes main results network case control studies italy collaborative group epidemiological studies ovarian cancer consistent inverse relations parity oral contraceptive use risk ovarian cancer menstrual hormonal factors early age menarche late menopause established associations limited impact ovarian cancer incidence population level serous endometrioid ovarian cancers mucinous clear cell types related current recent use hormone replacement therapy menopause strong associations alcohol tobacco overall direct link tobacco borderline mucinous cancers limited impact however overall ovarian cancer mortality direct associations ovarian cancer risk height bmi well possible relations selected dietary factors absence however consistent findings possible inverse association physical activity strong association family history ovarian cancer selected neoplasms including colorectum endometrium recognized risk factors explain limited proportion ovarian cancer cases population level key reason recent favourable trends ovarian cancer incidence mortality several high income countries widespread use oral contraceptive generations born copyright wolters kluwer health inc rights reserved
objective preterm children risk social difficulties including autism spectrum disorder asd study used eye tracking determine viewing behaviors may reflect difficulties design gaze patterns mean gestational age weeks mean birth weight mean chronological age months assessed viewing dynamic social scenes compared typically developing children asd temporo spatial gaze patterns summarized two dimensional plane using multidimensional scaling mds median children used characterize gazes children time spent viewing face also compared results children formed two clusters one mean mds distance comparable group small larger mean distance comparable asd group large large similar asd group spending significantly less time viewing face performance comparable initial could remain focused face thereafter conclusions children objectively classified two groups based gaze behaviors one group comparable children whereas difficulty maintaining attention exhibited atypical viewing behaviors similar asd group method may useful identifying children higher risk experiencing social difficulties japanese society child neurology published elsevier rights reserved
fuzzy improved water pollution index proposed based fuzzy inference systemand water pollution index method give comprehensive water quality rank also describe water quality situation quantitative value convenient water quality comparison ranks proposed method used assess water quality river sichuan china data used assessment collected four monitoring stations assessment results show river water quality presents downward trend overall water quality worst spatial variation indicates water quality nanbashequ section pessimal sake comparison fuzzy comprehensive evaluation grey relational method also employed assess water quality river comparisons three approaches assessment results show proposed method reliable research center eco environmental sciences chinese academy sciences published elsevier
genome wide association study identified gab associated alzheimer disease risk european population however inconsistent results reported east asian population performed updated analysis using samples including cases controls first investigated gab variant asian population using cases controls evaluate effect different populations selected cases controls european population used three genetic models found significant heterogeneity asian population fixed effect model analysis showed significant association asian population significant heterogeneity pooled east asian european populations fixed effect model analysis showed significant association pooled populations taken together findings suggest gab may contribute susceptibility european population east asian population elsevier rights reserved
data owners large volumes data outsource spatial databases taking advantage cost effective cloud computing model attractive demand features scalability high computing power data confidentiality outsourced databases key requirement therefore untrusted third party service providers cloud able view manipulate data paper proposes disc dynamic index spatial data cloud secure retrieval scheme answer range queries encrypted databases cloud service provider dynamic spatial index also able support dynamic updates outsourced data cloud server able support secure query processing updates cloud spatial transformation applied data spatial index encrypted using order preserving encryption transformation cryptography techniques disc achieves balance efficient query execution data confidentiality cloud environment additionally secure scheme disc proposed balance trade query results returned security provided security analysis section studies various attacks handled disc experimental study demonstrates proposed scheme achieves lower communication cost comparison existing cloud retrieval schemes
present family algorithms reduce noise astrophysical images image sequences preserving information original data retained conventional techniques family uses locally adaptive filters noise gates fourier domain separate coherent image structure background noise based statistics local neighborhoods image processing solar data limited simple shot noise additive noise reveals image structure easily visible originals preserves photometry observable features reduces shot noise factor little apparent loss resolution reveals faint features either directly discernible sufficiently strongly detected quantitative analysis method works best image sequences containing related subjects example movies solar evolution also applicable single images provided enough pixels adaptive filter uses statistical properties noise local neighborhoods data discriminate coherent features incoherent noise without reference specific shape evolution features technique potentially modified straightforward way exploit additional priori knowledge functional form noise
liquid liquid equilibrium data poly vinyl pyrrolidone pvp khpo system measured different values binodal curve fitted merchuk equation tie line compositions fitted othmer tobias bancroft equations refractive indices densities several homogeneous binary ternary solutions used calibration also measured within range mass pvp mass khpo viscosities densities electrical conductivities refractive indices binary pvp water potassium phosphate water ternary pvp potassium phosphate water systems measured correlated different values density data showed linear variation polymer salt mass fractions viscosity data pvp solutions correlated function mass fractions using nonlinear equation effects tie line lengths densities viscosities aqueous two phase systems represented also modified unifac nrf used calculate phase equilibria mention system fitted binary interaction parameters model reported
posture bridge girder plays important role safety efficiency bridge construction paper mainly proposed mathematical method determining position orientation bridge girder distributed incremental launching devices firstly background incremental launching construction introduced addition mechanical hydraulic design launching device iterated construction movements described analyzing characteristics incremental launching method distributed launching devices posture single device bridge girder determined mathematically posture determination method integrated bridge launching construction surveillance system application method practically verified launching construction fengxi suspension bridge finally
little population based work published mental health adolescents sexual gender ethnic minority double minority status study aimed provide overview mental health analysis data total high school students new zealand cross sectional nationally representative adolescent health surveys including total minority participants also ethnic minority minority status minority ethnicity female sex associated higher mental distress poorer well generally speaking double minority students reported poorer mental health majority students ethnicity reported better mental health minority new zealand european students explanations future directions research suggested explore double minority students negotiate mental health context communities cultures new zealand
current study used model based cluster analyses determine distinct variants adolescents ages high callous unemotional traits differ level anxiety history trauma sample consisted clinic referred youths primarily african american came low income families consistent hypotheses clusters emerged including group low traits well groups high traits differed level anxiety past trauma consistent past research incarcerated adults adolescents group high anxiety secondary variant likely histories abuse higher levels impulsivity externalizing behaviors aggression behavioral activation contrast group low anxiety primary variant scored lower measure behavioral inhibition measures impulsivity externalizing behavior higher scores secondary cluster found self report measures parent report measures youths primary cluster also perceived less credible reporters youths secondary cluster secondary variant cluster low traits reporter credibility differences suggest adolescents within primary variant may underreport level behavioral disturbance important assessment implications
giant leap made past couple decades introduction kernel based learning mainstay designing effective nonlinear computational learning algorithms view geometric interpretation conditional expectation ubiquity multiscale characteristics highly complex nonlinear dynamic systems paper presents new orthogonal projection operator wavelet kernel aiming developing efficient computational learning approach nonlinear dynamical system identification framework multiresolution analysis proposed projection operator wavelet kernel fulfill multiscale multidimensional learning estimate complex dependencies special advantage projection operator wavelet kernel developed paper lies fact closed form expression greatly facilitates application kernel learning best knowledge first closed form orthogonal projection wavelet kernel reported literature provides link grid based wavelets mesh free kernel based methods simulation studies identifying parallel models two benchmark nonlinear dynamical systems confirm superiority model accuracy sparsity
article addresses problem testing difference two correlated agreement coefficients statistical significance number authors proposed methods testing difference two correlated kappa coefficients require either use resampling methods use advanced statistical modeling techniques article propose technique similar classical pairwise test means based large sample linear approximation agreement coefficient illustrate use technique several known agreement coefficients including cohen kappa gwet fleiss generalized kappa conger generalized kappa krippendorff alpha brenann prediger coefficient proposed method flexible accommodate several types correlation structures coefficients requires neither advanced statistical modeling skills considerable computer programming experience validity method tested monte carlo simulation
aegilops kotschyi thermo sensitive cytoplasmic male sterility tcms system may facilitate hybrid wheat triticum aestivum seed multiplication production tcms line completely male sterile normal wheat growing season whereas fertility restored high temperature environment elucidate molecular mechanisms responsible male sterility fertility conversion candidate genes involved pollen development tcms employed rna seq sequence transcriptomes anthers tcms line ktma development sterile fertile conditions identified differentially expressed genes degs different stages including known genes nuclear genes plasmagenes novel genes bioinformatics analysis identified possible metabolic pathways involved fertility based kegg pathway enrichment degs expressed fertile sterile plants found genes encoding key enzyme phenylpropanoid biosynthesis jasmonate biosynthesis pathways significant upregulated uninucleate binuclate trinucleate stage interact myb transcription factors link play essential roles fertility conversion relevant degs verified quantitative pcr thus suggested phenylpropanoid biosynthesis jasmonate biosynthesis pathways involved fertility conversion tcms wheat provide new perspective effective foundation research molecular mechanisms fertility conversion cms wheat fertility conversion mechanism thermo sensitive cytoplasmic male sterile fertile wheat involves phenylpropanoid biosynthesis pathway jasmonate biosynthesis pathway myb transcription factors
new stage development space borne information systems creation global earth observation system full functioning system necessary provide uniformity measurements national systems members global system high quality measurement data requires implementation high level ground prelaunch calibration earth remote sensing instruments solve problems created calibration facilities basis large vacuum chambers vacuum reference radiation sources including sources basis black bodies wide aperture spectral range facility created fgup vniiofi cooperationwith fgup tsniimash ground calibration earth remote sensing instruments carried using blackbody models radiation sources known spectral radiance facility ground calibration remote sensing devices spectral radiance based usage large aperture blackbody labb diameter working temperature range radiation source calibration setup comprises set reference blackbodies blackbody phase transition gallium variable temperature blackbody temperature range reference blackbody cooled liquid nitrogen fourier spectrometer utilized comparator perform labb calibration spectral radiance second important characteristic labb uniformity spectral radiance across radiating aperture blackbody paper describes device measuring spatial homogeneity radiation power labb radiating surface device based use two color insb cdhgte detector equipped modulator lens mounted two axis translation stage suitable operation vacuum installed vacuum chamber labb measurement radiation uniformity modulator sequentially sends probing radiation spot either labb surface thermostatic radiation source detector input principle operation device described results measurements radiation power homogeneity across labb radiating aperture presented wide temperature range
study examined extent instructional practices science teachers barbados congruent best practices teaching scientific literacy additionally observation practice sought determine teachers demonstrated role classroom demonstration learning discourse learning goals nature classroom activities five hundred nineteen students secondary schools island teachers across schools participated study data collected means questionnaire observational schedule field notes found problem solving questioning mainly used classroom use experiments among least popular teaching strategies additionally results showed teachers display knowledge characteristics scientific literacy unsatisfactory generally findings indicate gap teaching scientific literacy expressed literature current instructional practices secondary science classrooms barbados
background recent biochemical physiological investigations focused fundament mood disorders thyroid dysfunction present study aimed address depressive disorder sample iranian hypothyroid women compared euthyroid individuals methods thirty consecutive hypothyroid female patients aged years referred endocrinology metabolism clinic rasoul akram hospital tehran within four month period assessed thirty healthy euthyroid subjects matched sex age educational level selected control assessment depression status depression anxiety stress scale dass employed results study showed higher mean depression score hypothyroid patients compared euthyroid ones versus significant association revealed mean depression score patients education level age occupation status marital status conclusion hypothyroid women predisposed depressive symptoms independent baseline demographic socioeconomic characteristics
novel switching circuitry fully differential millimetre wave applications presented structure proposed switching architecture includes cmos transistors distributed active transformer minimise chip size innovative topology based lumped components investigated resulting total size performance designed switch validated within dual mode local oscillator distribution circuitry band transceiver
study presents integration real time energy monitoring control system advanced reactive power compensation unit based fixed capacitor thyristor controlled reactor tcr firing angles thyristors located tcr controlled microcontroller order keep power factor within limits electrical parameters system measured specially designed circuits simultaneously transferred computer via data acquisition board thus real time data system observed visual user interface data obtained analyzed control process also regularly saved database system tested laboratory conditions different load characteristics experimental results verified system successfully accurately achieves compensation process operational conditions isa published elsevier ltd rights reserved
stem cell vaccination induce consistent strong anti tumor immunity cancer mice model antigenic similarity tumors embryos appreciated many years reflects expression embryonic gene products cancer cells cancer initiating stem cells taking advantage similarity tested prophylactic lung cancer vaccine composed allogeneic murine mscs based conception first compared tumor vaccines intervention effects adult mscs mscs simulated microgravity msc smg study balb mice vaccinated mscs msc smg compared mice vaccinated phosphate buffered saline pbs negative controls subcutaneously implanted human lung cancer cell line vaccinated mice monitored tumor growth potential vivo smaller tumor size less tumor weight observed mice vaccinated mscs msc smg compared control group particularly much significant group msc smg group mscs vaccination smg treated mscs inhibited proliferation promoted apoptosis tumor tissue smg msc vaccination induced boththl mediated cytokine response dependent cytotoxic response reduced proportion treg cells furthermore smg msc vaccination significantly increased mhc hsps proteins expression conclusion demonstrated smg could improve tumor suppressive activity msc enhanced anti tumor immune response mscs smg strongly associated higher expression mfic class molecule dcs abundance hsps smg treated mscs may make antigens msc cross presentable host dcs generating protective antitumor activity study gains insight mechanism mscs antitumor efficacy gives new strategy cancer therapies future published elsevier inc
background immobile patients body wash bed sometimes bathing option traditionally bed bath performed water soap however alternatives increasingly used health care washing without water one alternative claimed offer several advantages improved hygiene skin condition systematic review aims provide comprehensive overview evidence outcomes washing without water concept compared traditional bed bath methods controlled trials washing without water outcomes published collected means systematic literature search cinahl embase medline pubmed february additionally references citations searched experts contacted studies eligible study designs included outcomes washing without water products developed full body wash compared traditional bed bath controlled trials two researchers independently used standardized quality checklist assess methodological quality eligible studies finally outcomes categorized physiological outcomes related hygiene skin condition stakeholder related outcomes organizational outcomes data synthesis results potentially relevant articles subjected full text screening six studies met eligibility criteria two studies research group considered high quality results high quality studies show washing without water performed better traditional bed bath regarding skin abnormalities bathing completeness differences washing without water traditional bed bath found outcomes related significant skin lesions resistance bathing costs studies high quality conclusions limited moderate high quality evidence washing without water inferior traditional bed bath future research washing without water needed pay special attention costs hygiene stakeholder related outcomes experiences value perceptions patients nursing staff family
undocumented immigrant young adults growing united states face significant challenges qualified deferred action childhood arrivals daca program protections may alleviate stressors implications mental health wellbeing mhwb conducted nine focus groups daca eligible latinos ages california investigate health needs participants reported mhwb greatest health concern viewed daca beneficial increasing access opportunities promoting belonging peer support participants found daca also introduced unanticipated challenges including greater adult responsibilities new precarious identity thus immigration policies daca may influence undocumented young adults mhwb expected unexpected ways research impacts policy changes young immigrants mhwb guide stakeholders better address population health needs mhwb implications include need reduce fear deportation increase access services
extreme climate events floods drought cause huge impact daily lives order produce society resilient extreme events necessary assess impact frequent high intensity storm events design parameters article describes methodology develop future peak design discharges throughout united states used guidance map future floodplains order develop lower upper limit anticipated peak flow discharges two future growth scenarios representative concentration pathways rcps rcp identified weak strong climate scenario respectively based output global climate models generalized least square technique united states geological survey weighted multiple regression wreg program used develop regression equations relate peak discharges basin climate parameters contributing watershed design discharges reflect recent climate model results number frost days heavy rainfall days high temperature days snow depth found common extreme climate parameters influencing regression equations methodology extended flood frequency events rainfall data available future discharges utilized hydraulics models estimate floodplains assist resilient infrastructure planning outline climate change adaptation strategies
primary myelofibrosis pmf chronic philadelphia negative myeloproliferative neoplasm characterized skewed megakaryopoiesis overproduction proinflammatory profibrotic mediators lead development bone marrow fibrosis since recently uncovered upregulation mir pmf hematopoietic progenitor cells hpcs order elucidate role pmf pathogenesis unravelled effects mir overexpression hpcs showed enforced expression mir partially constrains proliferation favours megakaryocyte monocyte macrophage commitment hpcs interestingly identified lymphoid enhancer binding factor lef nuclear receptor subfamily group member nra transcripts mir targets downregulated mir overexpression hpcs well pmf cells remarkably knockdown nra hpcs mimicked antiproliferative effects mir overexpression silencing lef phenocopied effects mir overexpression hpcs lineage choice favouring megakaryocyte monocyte macrophage commitment collectively data unravel role mir hpcs fate decision suggest increased expression mir pmf hpcs could important skewing megakaryopoiesis production monocytes key players fibrosis pmf patients
people psychiatric disabilities demographic characteristics measures clinical status often used allocate scarce employment services study examined battery potential client predictors competitive employment testing hypothesis evidence based supported employment would mitigate negative effects poor work history uncontrolled symptoms substance abuse client factors secondary analysis unemployed social security disability insurance beneficiaries schizophrenia affective disorders examined baseline client factors predictors competitive employment analysis used logistic regression identify significant client predictors examined interactions significant predictors receipt evidence based supported employment work history strong predictor employment client measures fewer years disability rolls hispanic ethnicity fewer physical health problems modestly predictive evidence based supported employment mitigated negative client factors including poor work history participants poor work history benefitted supported employment even recent work experience evidence based supported employment helps people serious mental illness especially poor job histories obtain competitive employment factors commonly considered barriers employment diagnosis substance use hospitalization history misconceptions disability benefits often little impact competitive employment outcomes
doubly salient electrical generator dseg characteristics easy control high reliability used high speed field satisfy low speed high power characteristics direct driven wind power ddwp paper first analyzes control strategy dseg used ddwp studies novel direct driven doubly salient electrical wind generator dddsewg exterior rotor finite element analysis ansoft dddsewg fitted area wide speed load range simulation results matlab demonstrate positive electrical characteristics dddsewg
review discusses unmet needs patients attention deficit hyperactivity disorder adhd transitioning adulthood although awareness recognition adhd children adolescents adults improved recent years often interruption management disorder adolescent patients transition adult health care services review following objectives identify key issues patients adhd without early diagnosis face transition adulthood review current clinical practice country specific approaches management transition adulthood patients adhd discuss challenges facing clinicians patients drug treatment adhd initiated review current adhd guidelines transition management hong kong singapore south korea turkey africa examine economic consequences associated adhd review suggests transition period adult adhd may underresearched underserved area transition period plays important role regarding adhd symptoms may perceived acted upon adult psychiatrists studies needed explore characteristics transition period fraction adolescents mental disorders adulthood especially adhd crucial identify characteristics target appropriate interventions beginning course illness continues low recognition adult adhd severe lack medical services equipped diagnose care patients adhd transitioning child adult services
let sigma infinity convergent series infinity known real numbers paper referring osler lemma osler obtain explicit forms two bivariate series sigma infinity cos alpha theta sigma infinity sin alpha theta theta real variables alpha element element element illustrative examples also show obtain explicit form trigonometric series explicitly given three new integral formulae derived direction elsevier ltd rights reserved
method network plan project construction widely used complies requirements engineering construction management organization management especially suitable construction project present country network plan technology engineering project theory level foreign equivalent application project management especially lag compared supervision control implementing plan tracking adjustment basically still stay preparation plan paper analyzes present situation application network technology construction management puts forward ways methods improve application network planning technology
last two decades computational hydraulics undergone rapid development following advancement data acquisition computing technologies using finite volume godunov type hydrodynamic model work demonstrates promise modern high performance computing technology achieve real time flood modeling regional scale software implemented high performance heterogeneous computing using opencl programming framework developed support simulations across multiple gpus using domain decomposition technique across multiple systems efficient implementation message passing interface mpi standard software applied convective storm induced flood event newcastle upon tyne demonstrating high computational performance across gpu cluster good agreement crowd sourced observations issues relating data availability complex urban topography differences drainage capacity affect results small number areas
developing unified distributed communication environment processing spatial data integrates web desktop mobile platforms combines volunteer computing model public cloud possibilities main idea create flexible working environment research groups may scaled according required data volume computing power keeping infrastructure costs minimum based upon single window principle combines data access via geoportal functionality processing possibilities communication researchers using innovative software environment recently developed planetary information system http cartsrv mexlab geoportal updated new system provide spatial data processing analysis visualization tested based freely available earth remote sensing data well solar system planetary images various missions based approach possible organize research representation results new technology level provides possibilities immediate direct reuse research materials including data algorithms methodology components new software environment targeted remote scientific teams provide access existing spatial distributed information suggest implementation user interface advanced front end virtual globe system
history allergy allergic condition reported associated reduced risk types malignancies however understanding association colorectal cancer crc controversial conducted meta analysis crc risk individuals history allergy compared without history allergic condition pumbed embase databases searched relevant studies adjusted relative risk confidence interval pooled using random effects model nine studies including individuals eligible inclusion pooled estimate showed significant association history allergy crc risk adjusted subgroup analyses confirmed neutral association stratified tumor location colon studies adjusted rectum studies adjusted colorectum studies adjusted sex male studies adjusted female studies adjusted allery type asthma studies adjusted hay fever studies adjusted meta analysis existing evidence provides neutral association allergies crc risk future well designed prospective cohort studies conducted better understand association
worldwide demand healthcare exceeds individuals governments able afford priority setting therefore inevitable mental health services often given low priority decision making process drawing established economic criteria specifically work philip musgrove key factors influence government decision making health priorities reviewed factors include size health burden availability cost effective interventions reduce burden whether private markets provide necessary treatment efficiently whether catastrophic costs incurred accessing treatment whether negative externalities arise providing care rule rescue applies beyond setting priorities resource allocation governments also become involved need regulation maintain quality delivery healthcare providing field specific examples factor illustrate advocates eating disorder field may use evidence inform government policy resource allocation regulation support individuals eating disorder
study load balancing wireless networks single class traffic focusing attention important example wireless sensor networks analysis based wireless minimum cost problem optimization problem implicitly captures effects interference novel use arc cost function depends amount traffic flowing nearby links present algorithm optimizes flow modifying traffic along cycles constructed initialization phase operation may viewed trying satisfy kirchhoff voltage law electric circuit containing interferistors robust distributed minimal communication overhead converges quickly furthermore traffic elastic algorithm easily modified also perform congestion control
one important issues strategic management enhancing employees motivation contribute implementation strategies usually pay necessary attention strategies accordingly required consider calculate roles implementing strategies terms employees role organization managerial goal setter non managerial non goal setter role looking strategic performance measurement method involve roles since pervasive method literature cover roles properly research introduces method measures calculates strategic performance employees based two main parts project effectiveness managerial roles project efficiency non managerial roles method tested sample employees hormozgan cement company results show significant difference employees participated participate implementation strategies performance value achieved values tangible traceable therefore employees proper sense reaction outputs method
microgrid protection schemes different used conventional distribution networks incorporation distributed generation ability directional power flow island operation fault current delay parameters protective relays need recalculated updated response dynamic operation microgrid performance evaluation fault clearance time recovery time parameter estimation fault current trip delay protection scheme difficult require comprehensive modeling electrical network ied behaviors iec based communication paper present centralized scheme detailed modeling simulation aspects also demonstrate analysis simulation results helps overcoming forth mentioned difficulties
although decline self employment fundamental factor environment japanese labor market quarter century economic research self employment remained sparse short survey aims reboot empirical research first summarizes two mainstream literatures relation business cycle self employed entrepreneurship aspects self employment survey concludes neither fully explain decline self employment japan point relatively new literature nonpecuniary rewards self employment literature still developing suggests declining self employment related decline welfare particular comparisons welfare implications self employment versus non standard work important deepening understanding contemporary japanese society
objectives present study following ones study use drugs prosocial behaviour problem solving skills respect age gender analyze association prosocial behaviour problem solving skills use drugs descriptive cross sectional study performed amongst sample students spanish compulsory secondary education males age range years statistically significant differences found concerning alcohol use prosocial behaviour respect gender well concerning alcohol cannabis use respect age controlled effect age sex regression models variable best predicted alcohol cannabis use prosocial behavior results study enhance importance tailored interventions based promotion prosocial behaviours fundamental protective factor substances use alcohol cannabis amongst adolescents
report design temperature controlled tunable dual band terahertz absorber compact single unit cell consists two nested closed square ring resonators layer metallic separated substrate strontium titanate sto dielectric layer found absorber two distinctive absorption peaks frequencies thz thz whose peaks attained cooling absorber causes shift compared resonance frequency room temperature cooling temperature could attained two tunabilities exceeding frequency tunability owing variation dielectric constant low temperature fired ceramic ltcc substrate mechanism dual band absorber attributed overlapping dual resonance frequencies could demonstrated distributions electric field method opens avenues designing tunable terahertz devices detection imaging stealth technology elsevier ltd rights reserved
context software engineering evolving discipline new subareas continuously developed added structure better understand body knowledge taxonomies proposed knowledge areas objective objective paper characterize state art research taxonomies method systematic mapping study conducted based primary studies results increasing number taxonomies published since broad range venues including top journals conferences majority taxonomies grouped following sweboi knowledge areas construction design requirements maintenance illustration frequently used approach taxonomy validation hierarchy faceted analysis frequently used classification structures taxonomies rely qualitative procedures classify subject matter instances cases procedures described sufficient detail majority taxonomies target unique subject matters many taxonomy papers cited frequently taxonomies designed hoc way address issue revised existing method developing taxonomies systematic way conclusion strong interest taxonomies taxonomies extended revised taxonomy design decisions regarding used classification structures procedures descriptive bases usually well described motivated authors published elsevier
epigenetics array chromatin modifications customize cell stage condition specific manner information encloses plain dna molecules increasing evidences suggest importance epigenetic mechanisms development maintenance central nervous system fact large number newly discovered genetic causes neurodevelopmental disorders intellectual disability autism spectrum disorders many syndromes mutations within genes encoding chromatin remodeling enzymes review recent findings epigenetic origin human diseases emphasis disorders affect development nervous system discuss novel therapeutic avenues target epigenetic mechanisms
construction better practice sought employment knowledge management interest tacit knowledge grown due importance raising performance organizational levels aspects limits tacit knowledge places knowledge management approaches construction considered focus upon broad knowledge management categories rather details particular methods distinction knowing knowing coupled examination whether main mode knowing tacit explicit used analyse relationship tacit explicit knowledge construction significant general theoretical difficulties incorporating tacit knowledge objectivist knowledge management approaches predominate construction particularly since methods converting tacit explicit knowledge problematic improving performance requires appreciating limitations objectivist practice based knowledge management within context construction projects consideration performance management measures illustrates
expanded genetic testing brca mutations led identification reproductive aged women test positive mutation might impact attitudes decisions relationships childbearing use preimplantation genetic diagnosis pgd prenatal diagnosis pnd cross sectional survey administered self reported brca carriers investigate knowledge brca status influences issues mean age brca test disclosure years reported personal history cancer women unpartnered felt pressure get married women whose families complete reported carrier status impacted decision biological children women history cancer likely report knowledge brca status impacted decision child fifty nine percent thought pgd offered mutation carriers thought pnd offered conclusion knowledge brca status impacts attitudes regarding relationships childbearing carriers believe pgd pnd offered carriers study suggests brca carriers desire would benefit reproductive counseling test disclosure
present article serves quick office reference clinicians providing anticipatory guidance cognitive social emotional development newborns children five years age present review links recommendations specific evidence medical literature citing sources developmental standards advice may explored desired practising primary care providers indicated areas child development well addressed training available resources present article includes parenting information important clinical presentations clinicians may less familiar promoting attachment prosocial behaviours healthy sleep habits self discipline problem solving well managing behaviours part normal development separation anxiety tantrums aggression picky eating specific fears information development language literacy socialization also included
much attention given developing nanocomposites layered silicates owing great need advanced materials engineering fact pure polymers present behavior properties needed certain applications within context objective study influence molecular weight polyamide obtaining nanocomposites national organoclay mixture polyamide organoclay processed twin screw extruder characterized thermogravimetry ray diffraction xrd heat deflection temperature hdt possible observe xrd obtain structure exfoliated partially exfoliated studied systems found nanocomposites stabilities higher pure polymer values hdt systems significantly higher pure polyamide
paper novel lossless grounded negative inductance simulator proposed using one operational transresistance amplifier otra active element one capacitor three four resistors passive elements properties proposed negative inductance simulator verified using cmos current feedback operational amplifier cfoa based otra realization pspice proposed circuit also tested experimentally verify theoretical results application cancellation unwanted inductance tested using proposed inductance simulator
brain noradrenaline system plays important role central nervous control energy balance thus implicated pathogenesis obesity specific processes modulated neurotransmitter lead obesity overeating still matter debate tested hypothesis vivo transporter nat availability changed obesity using positron emission tomography pet methylreboxetine mrb twenty subjects comprising ten highly obese body mass index bmi metabolically healthy non depressed individuals ten non obese bmi healthy controls overall found significant differences binding potential bpnd values obese non obese individuals investigated brain regions including nat rich thalamus though additional discriminant analysis correctly identified individual group affiliation based regional bpnd one control case furthermore inter regional correlation analyses indicated different bpnd patterns groups survive testing multiple comparions data find overall involvement nat changes human obesity however preliminary secondary findings distinct regional associative patterns warrant investigation
applicability effectiveness case based reasoning cbr demonstrated various construction management areas including bidding international market selection safety hazard identification construction litigation preliminary cost estimation despite strong potential decision supporting tool construction studies applied cbr estimating preliminary duration necessary overall success construction project based recognition paper develops cbr model capable accurately estimating construction duration preliminary stage applicability effectiveness developed model tested application multihousing projects test results confirm strong potential cbr provide accurate estimate construction duration limited information available preliminary stage paper significant provides practitioners reliable decision supporting tool accurately estimating construction duration thus ultimately increases possibility successful project execution american society civil engineers
conducted two separate exploratory studies evaluate differences supervision wraparound home outpatient office child treatment interventions study one examined structure norms supervision groups well rates general disclosure direct supervisors study two specifically examined frequency child abuse neglect encountered intervention setting level disclosure supervision mandatory reporting events findings first study suggest wraparound clinicians received significantly less individual supervision colleague consultation office based counterparts additionally wraparound clinicians significantly likely withhold information client cases direct supervisors second study wraparound clinicians endorsed significant increases observed child abuse observed child neglect verbally reported child neglect compared office based counterparts regards mandatory reporting issues children wraparound clinicians found significantly less likely disclose issues pertaining child neglect direct supervisors office based clinicians studies show preliminary evidence needed increase individual supervision wraparound practice addition greater focus clinician disclosures related incidents child abuse neglect
background health disparities persist among morbidity mortality rates united states contributing significantly disparities ability pay health care largely access health insurance access capacity primary care health workforce purpose article examines key determinants health doh including demographics public regulatory policies health workforce capacity primary health outcomes four states united states context study potential association among health care disparities myriad doh among restrictive nurse practitioner scope practice sop regulatory environment documented influence access care health outcomes methods descriptive study explores current sop regulations access primary care health outcomes key chronic disease indicators diabetes hypertension obesity alabama colorado mississippi utah states represent greatest disparity chronic disease health outcomes obesity diabetes hypertension greatest difference modernization sop laws affordable care act greatly expanded access health care however estimated million americans total population remain uninsured discussion restrictive inconsistent sop policies may continue contribute health workforce capacity population health disparities across country particular concern primary care indicators study findings bring question whether states restrictive sop regulations impact access primary care may turn influence population health outcomes findings suggest need research nps essential meeting increasing demands primary care united states quality care indicator research supports use
fusion technology demonstrated good method generating large scale entangled coherent ghz state two small ones qed system importance study fuse small scale entangled coherent ghz states via optical system paper present scheme generating larger entangled coherent ghz state optical system virtue fusion technology key fusion mechanism realized photon detectors mach zehnder interferometer two arms immersed kerr media mode entangled coherent state mode entangled coherent state probabilistically fused mode entangled coherent state fusion scheme applies entangled coherent ghz state unit probability success feasibility analysis indicates fusion scheme may realized current experimental technology large scale entangled coherent ghz states may find new applications quantum communication
approach universal modeling tracker design input constrained unknown nonlinear input time delay stochastic sampled data systems newly proposed paper first improved observer kalman filter identification okid method uses current output measurement estimate current state newly proposed paper shown outperforms traditional okid method addition shown newly proposed current output based kalman filter well performed output estimator extreme case filter anymore becoming universal way formulating artificial system model real physical process without disturbing normal operation consequently proposed artificial system model following advantages capable quantifying stochastic deterministic characteristics dynamical system interest capable carrying analyses various control design methodologies achieve performance specifications pre study phase iii capable estimating missing abnormal output measurements testing practical operating phases furthermore alternative designed current output based observer newly proposed paper order develop modified observer based model predictive control mpc input constraints improve performance unknown nonlinear time delay stochastic system proposed artificial system model used together proposed constrained mpc long time prediction future input output sets closed loop setting carried finally operation temperature controlled real nonlinear input time delay blast furnace process presented case study paper show effectiveness proposed mechanism elsevier inc rights reserved
transforming growth factor atrial fibrillation introductiontransforming growth factor tgf important factor induces atrial fibrosis atrial fibrillation purpose study evaluate association tgf level clinical factors catheter ablation investigate impact tgf level outcome methods resultsthis prospective study included patients persistent group paroxysmal paf group control group patients underwent followed months paf group highest tgf levels patients early recurrence eraf defined episodes atrial tachyarrhythmia within month blanking period detected patients recurrent blanking period detected patients multivariate analysis low tgf level independent factor associated recurrent moreover recurrence ratio higher low tgf group high tgf group patients patients log rank test conclusionspaf associated higher tgf level moreover lower tgf level patients could cause recurrent
background autism spectrum disorders asds heterogeneous group neurodevelopmental conditions vary etiology phenotypic expression expressions asd characterized severe phenotype including autism intellectual disability asd autism history developmental regression asd minimally verbal autism asd understudied generally especially domain neuroimaging however neuroimaging methods potentially powerful tool understanding etiology asd subtypes scope methodology review evaluates existing neuroimaging research asd asd asd identified search literature using pubmed database discusses methodological theoretical practical considerations future research involving neuroimaging assessment populations findings paucity neuroimaging research asd asd asd findings exist often contradictory sparse ungeneralizable suggest greater sample sizes studies necessary important would paradigm shift toward multimodal imaging genetics approaches allow characterization heterogeneity within etiologically diverse samples
consider thin narrow rectangular plate two short edges hinged whereas two long edges free plate aims represent deck bridge either footbridge suspension bridge study nonlocal evolution equation modeling deformation plate prove existence uniqueness asymptotic behavior solutions initial data suitable functional spaces prove results stability instability simple modes motivated phenomenon visible actual bridges complement theorems numerical experiments elsevier inc rights reserved
background catheter ablations traditionally performed use fluoroscopic guidance exposes patient staff inherent risks radiation developed techniques eliminate use fluoroscopy cardiac ablations performing completely fluoroless catheter ablations patients years methods present retrospective analysis safety efficacy feasibility data consecutive patients underwent nonfluoroscopic catheter ablation targeting total arrhythmias including atrioventricular reciprocating tachycardia avrt atrioventricular nodal reentrant tachycardia avnrt atrial tachycardia atrial fibrillation premature ventricular contractions pvcs ventricular tachycardia perform fluoroless ablations using intracardiac electrograms electroanatomic mapping cases intracardiac echocardiography experience includes exclusively endocardial cardiac ablations results mean follow months recurrence rate avrt avnrt macro reentrant focal pvc major complications occurred five patients minor complications occurred three patients deaths occurred fluoroscopy used one instance minutes confirm venous access conclusions completely fluoroless catheter ablations may routinely performed endocardial ablations without compromising safety efficacy procedural duration
early life neglect increases risk development psychopathologies childhood adulthood including depression anxiety disorders recently reported epigenetic changes dna derived saliva three genes predicted depression cohort maltreated children dna binding protein inhibitor glutamate nmda receptor grin tubulin polymerization promoting protein tppp validate role genes depression risk secondary analyses conducted gene expression data obtained medial prefrontal cortex mpfc tissue mice subjected model maternal neglect included maternal separation early weaning msew anxiety depression like phenotype data derived using elevated plus maze epm forced swimming test fst respectively also available secondary analyses behavioral tests conducted msew control adult male mice days old grin tppp gene expression mpfc found significantly predict behavioral differences epm fst results support role genes etiology depressive anxiety phenotypes following early life stress published elsevier
converters often exhibit undesirable oscillations due nonlinear dynamics digitally controlled converters degrees nonlinearity terms quantization analog digital converter digital pulse width modulator giving rise well known phenomenon limit cycle oscillations study different hitherto unreported class oscillations digitally controlled converters reported origin traced asymmetric saturation duty cycle study attempts provide physical insights behind phenomenon saturation generated oscillation sgo identify converter system components responsible challenges traditional stability analysis system highlighted followed simplified analysis leading calculation oscillation free operating zone effects system parameters sgo results used show potential ways oscillation avoided using sgo immune designs simulation experimental results provided illustrate points substantiate claims
paper refers recovering waste heat hot gases exhausted internal combustion engines ices driving electric generators egs full partial load topic particular interest developing countries electric grids underdeveloped missing electricity generated locally using classical fuels heat recovery system based organic rankine cycle orc novel method proposed optimum design orc based systems operating combination ice partial loads first orc based systems coupled ices operating full load treated specific results operation full load follows optimum superheating increment ranges degrees depending type working fluids pinch point temperature difference exits flue gas temperature working fluid evaporator inlet iii total area evaporator close total area condenser fact facilitates manufacturing surface area preheater zone total surface area boiler zone superheater zone respectively second case orc based systems coupled ices operating partial load considered specific results case follows net power may maximized optimizing working fluid mass flow rate ice coupled orc based system overall thermal efficiency combined system eta ice orc higher thermal efficiency ice operating alone example case treated eta ice orc higher hits loads respectively elsevier ltd
simulation based comparative analysis implemented assess different incentives low zero emission vehicles zev achieve deep reductions greenhouse gas ghg emissions new zealand purpose integrated energy system model enabling simultaneous simulation fuel supply energy markets refueling infrastructure evolution fuel demand used demand side nested multinomial logit framework gives share new vehicle types light heavy duty vehicles based consumer preferences toward vehicle fuel attributes different supportive prohibitive scenarios compared supportive scenarios introduce incentives terms initial fuel infrastructure support zero emission vehicle subsidies prohibitive strategies impose different types bans new adoption petroleum fuel vehicles simulation results compare implications transition pathways vehicle fleet mix fuel demand economic costs ghg mitigation findings show augmentation initial infrastructure support subsidy incentives zevs increase ghg mitigation without meaningful rise mitigation cost strategy effective emissions reduction banning internal combustion engine vehicles icevs banning icevs hybrid electric vehicles hevs doubles cumulative mitigation albeit substantial cost increase compared banning icevs alone banning icevs hevs could less cost effective reducing ghg emissions rigorous ban petroleum fuel vehicles elsevier ltd rights reserved
conduct simulations device structures typical electron beam induced current ebic imaging solar cell structures type cdte absorber layers charged grain boundaries large signal enhancement found near depleted positively charged grain boundaries ebic simulation contrast previous claims solar cell performance drops contrast little ebic contrast seen cell performance improves accumulated negatively charged grain boundaries introduced explore impact doping level lifetimes grain boundary charge provide insight design improved thin film solar cells
paper proposed new test function construct exact solitary wave solutions nonlinear evolution equations dimensional jimbo miwa equation taken example illustrate effectiveness proposed test function aid maple program cumbersome calculation carried obtain new exact solutions said equation exact solutions obtained enrich solution structure higher dimensional nonlinear wave equation evidently method applied nonlinear evolution equations well
paper investigates effect leader relational transparency follower organizational deviance followers perception leader behavioral integrity trust leader multi level modeling results multisource survey based field study hospitality student project teams show behavioral integrity mediates relationship leader relational transparency follower trust leader furthermore multi level path analysis suggests leader relational transparency team level construct exerts cross level effect follower organizational deviance mediating roles behavioral integrity follower trust leader study yielded theoretical practical implications useful hospitality leaders published elsevier ltd
background cardiac cephalalgia rare disease occurring episode myocardial ischemia relieved nitroglycerine though cases reported since mechanism yet obscure herein case presented discussed relevance previous literature propose novel hypothesis mechanism method patient cortical hypoperfusion headache attacks presented never reported published cases via pubmed http www ncbi nlm nih gov pubmed english literature reviewed results patient suffering presented cerebral hypoperfusion headache attack phenomenon observed since introduced literature review summarized clinical presentations neuroimaging features ecg coronary angiography features patients conclusion based phenomenon hypoperfusion event headache vessel constriction hypothesis proposed including two potential physiological mechanisms underlying pathophysiology
new analytical accurate approximations evaluation temperature dependence heat capacity electrical resistivity motor winding presented approach based debye method bloch gruneisen theory controlling heat capacity electrical resistivity motor winding variation temperature analytical evaluation general shows results motor winding heat capacity resistivity satisfactory wide range temperature variations comparison calculation results literature data show approach accurate efficient hydrogen energy publications llc published elsevier ltd rights reserved
currently several irreversible btk inhibitors targeting cys residue preclinical clinical development however inhibitors also targeted idnases bmx jak egfr bear highly similar active cysteine residues structure based drug design approach discovered highly potent irreversible btk inhibitor compound chmfl btk displayed high selectivity profile kinomescan score among kinases mutants concentration compound completely abolished bmx jak egfr activity ray crystal structure cysteine serine mutation mediated rescue experiment confirmed irreversible binding mode also potently inhibited btk auto phosphorylation arrested cell cycle phase induced apoptosis pfeiffer cells believe features would make good pharmacological tool study btk related pathology elsevier masson sas rights reserved
stepped spillway steps act macroroughness elements contributing enhanced energy dissipation significant aeration skimming flow upstream flow motion nonaerated free surface appears smooth glossy inception point free surface aeration developing flow region turbulent boundary layer grows outer edge boundary layer interacts free surface air entrainment takes place flow properties developing flow region documented carefully large stepped spillway model upstream flow controlled broad crested weir critical flow conditions observed along weir crest although pressure distributions hydrostatic upstream downstream ends downstream broad crest upstream inception point free surface smooth although significant free surface curvature observed discharges boundary layer growth faster smooth chute identical flow conditions inception point free surface aeration observed boundary layer thickness reached flow depth approximate location inception point free surface aeration flow depth inception compared successfully previous laboratory prototype results
paper investigates complete synchronization two boolean networks via logic control feedback control open loop control proposed make slave network completely synchronized master boolean network using algebraic state space representation boolean networks derive several necessary sufficient conditions complete synchronization two boolean networks two examples given illustrate obtained results
report case fungemia immunocompetent patient administration probiotic containing saccharomyces boulardii demonstrated strain relatedness yeast probiotic capsule yeast causing fungal infection using genomic proteomic typing methods study questions safety preventative biotherapy elsevier inc rights reserved
paper describes modeling controlling autonomous cruise control autonomous car using bond graph modeling developed model using bond graph formulation incorporating actuator dynamics finally state space representation later subjected model robust control theory modify nominal model standard format used parametric uncertainty finally synthesized using lqr control technique compared results feedback system
nowadays modern way human life lead increasing exposure residential indoor air pollution sources building materials solvents used cleaning paints bio contaminants tobacco smoke carpets combustions associated adverse health effects especially infants young children comprise vulnerable subpopulation spend majority time indoors home respiratory systems development children health outcomes studied literature include primarily respiratory diseases asthma impairment lung function wheeze dry cough allergic disorders atopic dermatitis rhinitis methodology followed determination health impacts varies among questionnaires doctor diagnosis collection urine samples skin prick tests spirometric measurements blood samples depending health problem examined main indoor air pollutants measured linked children health included particulate matter volatile organic compounds vocs formaldehyde carbonyl compounds carbon dioxide carbon monoxide heavy metals several biological agents furthermore parameters geographical area house type residence also taken consideration purpose current study carry state art link residential air quality children health review focused methodological approaches used assessment air quality homes determination several health effects children
polyamines essential living organisms involved several vital cell functions biosynthetic pathway polyamines regulation well established sense ornithine descarboxylase odc enzyme acts one controlling factors entire pathway work assessed inhibition odc alpha difluoromethylornithine dfmo alternaria alternate observed fungal growth mycotoxin production reduced inhibition completely restored addition exogenous putrescine actually increasing concentrations putrescine growth media negatively affected mycotoxin production corroborated downregulation pksj altr genes involved mycotoxin biosynthesis also studied polyamine metabolism alternate goal finding new targets compromise growth mycotoxin production capacity sense tested two different polyamine analogs amxt amxt observed partially controlled alternate viability vitro vivo using tomato plants finding strategies design new fungicide substances becoming matter interest resistance problems emerging published elsevier ltd
neuropathic pain caused damage nervous system resulting aberrant pain associated gene expression changes sensory pathway however molecular mechanisms fully understood non coding ribose nucleic acid ncrna rna molecule translated protein ncrnas involved many cellular processes mutations imbalances repertoire within body cause variety diseases although ncrnas recently shown play role pathogenesis specific effects ncrnas remain largely unknown study sequencing analysis performed investigated expression patterns ncrnas spinal cord following spared nerve injury induced total long non coding rnas lncrnas micrornas mirnas circular rnas circrnas mrnas significantly regulated days spared nerve injury sni surgery next quantitative real time polymerase chain reaction pcr performed validate expression selected lncrnas mirnas circrnas mrnas bioinformatics tools databases employed explore potential ncrna functions relationships data showed significantly involved pathways sni pathogenesis ribosome pik akt signaling pathway focal adhesion ecm receptor interaction amoebiasis protein digestion absorption addition lncrna mirna mrna circrna mirna mrna network constructed first study comprehensively identify regulated ncrnas spinal cord demonstrate involvement different ncrna expression patterns spinal cord pathogenesis sequence analysis information enable research pathogenesis facilitate development novel therapeutics targeting ncrnas
operational excellence strategies relate tqm philosophy relate organisational excellence performance first part paper describes use tqm program implementation manufacturing engineering corporation new zealand program evaluation undertaken using variation kanji pyramid model business excellence model uses customer satisfaction critical success factor organisation second part paper reports self assessment project conducted one corporation local sales branches using tqm tools means enhancing quality service customers finally paper reports organisation position business excellence model suggests recommendations future implementation future research possibilities
large number asthmatic patients particularly females present inadequate disease control depressive symptoms reportedly common asthma related poor disease control mechanism association still unclear poor quality sleep frequently observed asthmatics also manifestation depression related uncontrolled asthma study aimed investigate relationship depressive symptoms sleep quality asthma control cross sectional study women previous diagnosis asthma reference center fortaleza brazil depressive symptoms assessed beck depression inventory bdi quality sleep evaluated pittsburgh sleep quality index psqi daytime sleepiness epworth sleepiness scale ess asthma control asthma control test act inadequate asthma control act excessive daytime sleepiness ess depressive symptoms associated poor quality sleep inadequate asthma control regression analysis showed depressive symptoms sleep quality independent predictors level asthma control asthma control women independently associated depressive symptoms quality sleep suggesting patients might benefit simple measures promote healthy sleep behavior sleep hygiene also routine screening depression relevant particularly poorly controlled cases
background suggested lifestyle factors smoking overweight stress may influence prevalence severity hand eczema objectives investigate association lifestyle factors hand eczema severity cohort patients work related hand eczema methods individuals work related hand eczema notified period june andnovember included questionnaire based cross sectional study participants responded questionnaire including questions lifestyle factors well photographic guide assessment severity hand eczema questions quality life results total individuals women men responded questionnaire included study strong associationwas found tobacco smoking hand eczema severity whereas significant association found bodyweight stress factors linked severe eczemaweremale sex older age respectively wet work conclusion data present study strongly support association smoking hand eczema severity however owing cross sectional design study conclusion causation drawn
objective perceived injustice defined appraisal regarding severity irreparability loss associated pain blame sense unfairness recent findings suggest perceived injustice important risk factor elevated disability associated chronic pain however mechanisms perception leads disability well understood therefore current study aimed examine mediating role pain acceptance relation perceived injustice chronic pain outcomes pain intensity pain related disability psychological distress method cross sectional study used sample individuals community report chronic pain participants completed injustice experience questionnaire chronic pain acceptance questionnaire pain rating intensity scale modified brief pain inventory hospital anxiety depression scale results results revealed significant direct links perceived injustice pain intensity disability distress well indirect links perceived injustice acceptance pain pain disability confidence interval psychological distress confidence interval discussion clinical theoretical implications discussed along future research directions
combined practical teaching status quo current mechanical undergraduate majors paper analyzes material forming control engineering major practice teaching mode main problems gives ideas implementation practical teaching reform paper creatively gives energy efficiency evaluation form teaching link introduces virtual internships systems use case teaching students participate actual production needs research direction teachers order complete graduation design trinity completing whole undergraduate teaching process important improving practical ability creative ability students
paper introduces new voltage regulator module vrm merges highly efficient switched inductor converter main unit load side switched capacitor based converter assist load transient events resulting hybrid vrm exhibits improved dynamic performance loading unloading transient events maintaining compact design reduced output capacitance lower components stress hybrid controller developed allows operation based output voltage measurement alone reducing circuit complexity power processing efficiency analysis carried shows efficiency improvement favor hybrid vrm compared time optimal control varying load conditions operation vrm verified prototype peak power conversion efficiency demonstrating near ideal transient recovery
present study evaluates prophylactic efficacy alpha tocopherol alpha toh resveratrol res coenzyme coq loaded self nanoemulsifying drug delivery system alpha toh res coq snedds dimethylbenz anthracene dmba induced breast cancer model snedds formulation components rationally selected optimized maximum drug loading applying design experiments evaluated stability simulated gastrointestinal fluids functional stability antioxidants vitro release caco cell uptake oral bioavailability prophylactic anticancer activity snedds demonstrated excellent stability stimulated gastrointestinal fluids functional activity antioxidants confirmed diphenylpicrylhydrazyl dpph scavenging assay wherein significantly higher antioxidant activity observed case snedds compared free antioxidants coumarin loaded snedds formulation demonstrated remarkably higher caco cell uptake comparison free indicative efficient internalization sub micron snedds droplets caco cells line caco cell uptake observations alpha toh res coq snedds showed similar similar fold increase auc infinity values res coq comparison free antioxidants significantly lower tumor volume similar found case animals treated alpha toh res coq snedds comparison free antioxidant combination similar dmba control similar groups conclusively proposed strategy posed great potential improving prophylactic activity antioxidants hold promise exploration
order optimize energy production mfcs better understanding anodic communities essential objective determine taxonomic structure bacterial communities present surface anode formation development electro active biofihns mfcs inoculated fresh primary clarifier overflow quantitative microbial community dynamics evaluated function time electrical performance using rrna gene based phylogenetic microarrays flow cytometry results show bacterial community stabilized partially completely voltage output stable geobacter appeared predominant genus whose growth associated voltage genus still developed declined voltage stabilization flow cytometry revealed genus showing decreasing proportional fluorescence intensity time still actively respiring bacteria thus active albeit minor members biofilm finally study shows anodic biofilm selection maturation still occurring days operation ten days voltage stabilized
study investigated association mmp mmp single nucleotide polymorphisms snps alcohol induced osteonecrosis femoral head onfh chinese males cases control subjects minor allele mmp associated fold decrease alcohol induced onfh risk allelic model genetic model adjusted age associated decreased risk alcohol induced onfh dominant model log additive model mmp associated increased risk codominant model dominant model dominant model log additive model mmp associated decreased risk dominant model log additive model haplotype analysis showed cgatatgt sequence mediated decreased alcohol induced onfh risk therefore among chinese males mmp mmp decrease alcohol induced onfh risk mmp increases study needed validate conclusion
past research showed people accumulate knowledge people objects like compared dislike knowledge commonly assumed lead differentiated mental representations therefore people perceive others like less similar one another others dislike predict opposite outcome based density hypothesis unkelbach fiedler bayer stegmtiller danner accordingly positive impressions less diverse negative impressions ways liked many ways disliked therefore people perceive liked others similar one another disliked others even though knowledge liked others seven experiments confirm counterintuitive prediction show strong association liking perceived similarity person perception discuss implications results different aspects person perception elsevier inc rights reserved
olive oil production increases amount olive oil products cause environmental problems thus new ways utilize products needed present study five bioactive characteristics olive oil products assessed namely antioxidant anti bacterial anti melanogenesis anti allergic collagen production promoting activities first extracts leaves may october stems may october flowers olive milled waste fruit pulp seeds prepared using two safe solvents ethanol water according hplc analysis folin ciocalteu assay ethanol extracts leaves may october stems may october flowers contained oleuropein ethanol extract stems showed highest total phenol content oleuropein may contribute antioxidant anti melanogenesis activities leaves stems flowers however active compounds synergistic effects present ethanol extracts also likely contribute anti bacterial activity leaves flowers anti melanogenesis activity parts anti allergic activity olive milled waste collagen production promoting activity leaves stems olive milled waste fruit pulp study provides evidence products olive oil potential developed used skin care industry copyright john wiley sons ltd
existence large matter antimatter asymmetry violation quark system predicted kobayashi maskawa theory established factory experiments belle babar however explain magnitude matter antimatter asymmetry universe live today indicates undiscovered new physics exists belle experiment next generation factory expected reveal new physics accumulating times data similar belle belle computing system handle amount beam data eventually corresponding several tens petabyte per year operation superkekb accelerator designed instantaneous luminosity situation expected one site kek able provide computing resources whole belle collaboration including resources raw data processing also production physics analysis done users order solve problem belle employed distributed computing system based dirac provides interoperability heterogeneous computing systems grids different middleware clouds local computing clusters since last year performed mass production campaigns confirm feasibility find possible bottleneck computing system parallel also started data transfer challenge transpacific transatlantic networks presentation describes highlights belle computing current status also present experience latest production campaign
current study explored relationships declarative pointing theory mind abilities children years age measures used examine theory mind tom included parental questionnaire scaling theory mind tasks results showed dissociation expressive informative pointing regarded two subcategories declarative function tom abilities significantly related production informative pointing production expressive pointing distinction might explained special features associated informative pointing early signs cooperation abilities results might key implications psychologists may help improve evaluation intervention programs development social skills preschoolers
codesign integration optical modulators cmos drivers crucial high speed silicon photonic sip transmitters reach full potential low cost low power electronic photonic integrated systems present cmos driven sip multi level optical transmitter implemented using commercially available lateral junction process uses mach zehnder modulator mzm segmented increase speed lower required power per segment basis level achievable cmos multi channel driver designed implemented cmos providing swing push pull configuration gbaud binary data cmos input manipulated via digital logic produce proper persegment drive signals generate four level pulse amplitude modulation optical signal multi level modulation achieved using binary signals input dac less cosimulation optical electrical circuits shows good agreement experiment reliable transmission achieved without post compensation using postcompensation
road designers assume drivers follow road alignment trajectories centred lane move design speed parallel road centreline horizontal alignment therefore assume horizontal alignment indicates designed trajectory driving path indicates operating trajectory however present necessary tools measure relationship designed alignment possible vehicle trajectories paper two objectives develop understanding root causes differences road alignment vehicle trajectories define calibrate model estimates local curvature trajectories basis designed horizontal alignment two objectives pursued carrying naturalistic survey using vehicles equipped high precision gps real time kinematics rtk mode driven test drivers road sections known geometric characteristics results provide insight effects road geometrics driver behaviour thus anticipating possible driving errors unexpected undesired behaviours information used correct possible inconsistencies making decisions design stage elsevier ltd rights reserved
paper deals susceptibility prediction integrated circuits conducted interference coupled power supply pins integrated operational amplifier studied first case integrated circuit electromagnetic icem model used describe inner power distribution network theoretical study experimental measurement curve fitting method proposed obtain icem model parameters different kinds measurements without knowing precise inner physical structure information opa direct power injection dpi experimental test conducted measure susceptibility conducted sine wave noise immunity measurement common simulation susceptibility criterion obtained finally whole simulation model dpi setup including icem model opa established predict susceptibility model perfectly verified mhz frequency range
objectives explore performance retrospective health data collected athletes athletics championships analysis risk factors competition injury illness methods european athletics indoor championships self report questionnaire phq developed record health status athletes weeks prior championship physician based surveillance competition among athletes registered compete pursued championships results athletes sample submitted complete phq athletes sustained least one injury illness championships training week predisposed sustaining competition injury recent health problem competition illness among registered athletes injuries registered athletes reported injuries caused track overuse illnesses reported registered athletes upper respiratory tract infection gastro enteritis diarrhoea reported diagnoses conclusions pre participation screening using athletes self report phq showed promising results regard identification individuals risk indoor injury types could attributed extrinsic factors small track size track inclination race tactics elsevier ltd rights reserved
background oncology nursing often source substantial stress nurses many nurses particularly novice nurses inadequate preparation care patients end life families unless nurses prevent manage work related stress using effective coping strategies oncology nursing staff continue suffer burnout compassion fatigue objectives purpose article identify stress levels stressful factors nurses working oncology outpatient units explore coping behaviors work related stress oncology staff nurses outpatient units methods descriptive cross sectional design used identify stress levels stressful factors outpatient oncology nurses investigate differences stress levels among nurses demographic characteristics explore coping behaviors nurses study participants included rns licensed practical nurses completed nursing stress scale three open ended questions demographic questionnaire findings highest sources stress workload patient death dying demographic variables age work experience nursing showed significant positive relationship work related stress scores three frequently used coping behaviors verbalizing exercising relaxing taking time self continuing education programs stress management highly recommended outpatient oncology nurses nurtured supported tailored interventions multiple levels help find effective coping strategies develop self care competencies although younger less experienced nurses lower mean stress scores older experienced nurses continuing education programs tailored interventions would helpful oncology nursing staff
dense wavelength division multiplexing dwdm sdh rings extensively deployed core networks metropolitan area networks man furthermore advances optical adm oadm optical dxc oxc erbium doped fiber amplifiers edfa resulted evolving core networks man optical networks due low cost flexibility low loss oadm based fiber grating optical circulator exhibited potential applying dwdm sdh ring networks although fiber grating based oadm feature low loss edfa always deployed compensate loss improve network performances however amplified spontaneous emission ase noise limit improvement network performances fiber grating stable reliable filter high performance filter ideal simultaneously achieving wide band signal transmission high level ase noise suppression amplified dwdm networks article performance analysis amplified dwdm sdh ring oadm based fiber grating optical circulator performed explicit method signal flow graph results show throughput power penalty amplified dwdm sdh ring fiber grating based oadm effectively improved considering ase suppression fiber gratings additionally network performances pre amplifying post amplifying line amplifying schemes analyzed implying network performance optimization amplified dwdm sdh ring fiber grating based oadm could achieved proper scheme
taking advantage hirota bilinear form four classes lump type solutions dimensional jimbo miwa equation presented symbolic computation maple special choices involved parameters guaranteeing analyticity fourth solution given together two particular lump type solutions
several studies reported declines adaptive behavior amongst children fragile syndrome fxs starting middle childhood examined effects maternal responsivity adaptive behavior children fxs visited times homes early middle childhood analyses indicated sustained maternal responsivity significant positive impact trajectories communication lesser extent adaptive behavior domains middle childhood many effects remaining significant controlling autism symptoms developmental level children showed declines adaptive behavior middle childhood sustained high levels maternal responsivity minimized amount decline observed communication socialization daily living domains
context coffee silverskin food product coffee roasting industry studied active ingredient skin care products due high potential antioxidant activity low cytotoxicity another food waste used ingredient promising characteristics obtained medicago sativa antioxidants isoflavones content high objective aim study evaluate characterize new body formulation containing two food products extracts materials methods different parameters rheological behavior color antioxidant content microbiological analysis body cream formulation containing products csms formulation without extracts evaluated stability study days different temperatures moreover vitro cell toxicity vivo skin safety protective effects also assessed results formulation showed stable physical properties antioxidant activity days storage vitro toxicity screened two skin cell lines fibroblasts keratinocytes toxicity reported vivo test carried showed respect irritant effects csms formulation regarded safe topical application skin hydratation improved days use also considering consumer acceptance volunteers classified pleasant conclusions csms formulation stable safe topical use adverse side effects observed application period testing improving skin protective properties
purpose randomized controlled trials reducing high hematocrit hct patients polycythemia vera protects cardiovascular disease cvd events whereas increasing hct anemia patients causes cvd events hct influenced environmental lifestyle factors given limited knowledge concerning drivers hct took agnostic approach identify drivers hct methods used environment wide association study identify environmental lifestyle factors associated hct older chinese adults mean age years guangzhou biobank cohort study evaluated role nutrients environmental contaminants two metals available participants six lifestyle factors relation hct adjusted sex age recruitment phase socioeconomic position results mutually adjusted model vitamin serum calcium serum magnesium alcohol use associated higher hct whereas physical activity associated lower hct conclusions despite difficulty ascertaining causality finding expected vitamin physical inactivity novel factors serum calcium serum magnesium alcohol use strongly associated hct illustrates utility environment wide association study generate hypotheses regarding potential contribution modifiable exposures cvd elsevier inc rights reserved
energy management internal combustion engine waste heat recovery system presents complex problem coupling issues energy recovery energy utilization addition problems arising large thermal inertia energy network commander tracker executor energy manager framework proposed management solution approach commander designed optimally split engine exhaust energy among different energy devices energy network lowest fuel cost disturbance estimation based receding horizon controller designed tracker follow commander commands real time commander decisions made real time based energy device efficiency model torque demand given driver corresponding heat rejection requirement whole system tracker works trajectory follower transform commander decisions actuators control objectives executor ensures energy management goals achieved line actuators control objectives energy network constructed taken example simulation study simulation results indicate manager exhibited fairly good fuel saving potentiality along whole driving cycle proposed commander showed eective exhaust energy splitting performance tracker scheme demonstrated good tracking capability robustness
study part longer term project provide embodied conversational agents ecas behaviors enable build maintain rapport human partners focus paralinguistic behaviors especially nonverbal behaviors role communicating rapport using eca guides players speech controlled game attempt measure familiarity built humans ecas across several interactions based paralinguistic behaviors particular studied effect differences amplitude nonverbal behaviors eca interacting human across two conversational sessions results suggest increasing amplitude nonverbal paralinguistic behaviors may lead increased perception physical connectedness humans ecas
aim assess proportion women requiring referral endocrinologist carrying routine screening maternal thyroid disease simultaneously screening syndrome november september women first trimester combined test screened symptomatic investigated thyroid problems excluded first half period blood sample tested anti thyroid peroxidase tpo antibodies serum thyroid stimulating hormone tsh free thyroxine thereafter used women least one analyte outside range tpo tsh pml referred endocrinologist counseling women screened tsh antibody levels outside range used thereafter positive results due single abnormal marker much higher positive rate multiple pregnancies compared singletons association positivity maternal age higher rate small ethnic group asians lower rate among smokers following assisted reproduction routine antibody hormone testing time combined test generated large number referrals overload services
introduction family plays important role patient environment complexity intensive care unit services generates situational emotional crisis immediate family causes anxiety stress objective evaluate perception relatives critical patients verbal nonverbal communication emotional support provided nursing staff hospitalization intensive care unit belong social level clinic cucuta city materials methods quantitative descriptive cross sectional study conducted sample consisted relatives data collection used instrument perception relatives critical patients according nursing work situational crisis results perception family favorable expressing positive connotation discussion relatives patients consider work nursing humanized behavior care focused valuation human holistic care given characterized behaviors empathy effective communication affection touch conclusions humanize intensive care unit allows recognizing family central axis assistance actions collaborative family healthy family tools fight despair generates income patients critical hospitalization service
deep learning powerful state art technique image processing including remote sensing images letter describes multilevel architecture targets land cover crop type classification multitemporal multisource satellite imagery pillars architecture unsupervised neural network used optical imagery segmentation missing data restoration due clouds shadows ensemble supervised nns basic supervised architecture use traditional fully connected multilayer perceptron mlp commonly used approach community random forest compare convolutional nns cnns experiments carried joint experiment crop assessment monitoring test site ukraine classification crops heterogeneous environment using nineteen multitemporal scenes acquired landsat sentinel satellites architecture ensemble cnns outperforms one mlps allowing better discriminate certain summer crop types particular maize soybeans yielding target accuracies major crops wheat maize sunflower soybeans sugar beet
paper examines students achievements solving problems misunderstandings using models mixed research methodology applied quantitative research investigated performance students various levels high school gpas correlated rating lecturers teaching proficiency four lecturers mechanical electronics engineering students participated study achievement tests consisting problems solved using models diode ideal operational amplifier implemented introductory courses electronics students taught lecturers rated high levels teaching expertise achieved significantly higher grades tests students taught lecturers receiving lower ratings teaching expertise tests investigated performance three taxonomy levels results consistent three levels grades knowledge taxonomy level higher grades routine level higher grades interpretation level expected qualitative research based analysis students written explanations face face interviews exposed three kinds misunderstanding purpose engineering models simplify calculations yield usable reliable results nonlinear problem solved using linear concepts accuracy solution indicated number decimal places result rather closeness actual value
introduction autism spectrum disorders asd complex set neurological dysfunction development characterized deficits social non verbal interaction studies explored executive functioning asd preschoolers aim pilot study assessment executive functioning preschool children asd material methods asd children males female mean age years enrolled study compared control group typically developing children males females mean age subjects underwent assessment executive functioning brief test results two groups matched age gender table shows comparison two groups brief significantly higher scores subscales asd children compared controls conclusions despite small sample examined results study agree already known literature confirm presence significant deficit executive functions subjects asd emphasizing first time emergence problems early stage development demanding studies confirm
systematically review literature bosniak classification system determine diagnostic performance diagnose malignant cystic lesions prevalence malignancy bosniak categories predefined database search performed january january two independent reviewers extracted data malignancy rates bosniak categories several covariates using predefined criteria study quality assessed using quadas meta analysis included data pooling subgroup analyses meta regression investigation publication bias total studies included lesions investigated data observer experience inter observer variation technical standards insufficiently reported pooled rate malignancy increased bosniak bosniak iif iii several study design related influences malignancy rates subsequent diagnostic performance indices identified bosniak classification accurate tool stratify risk malignancy renal cystic lesions aeuro cent bosniak classification accurately rule malignancy aeuro cent specificity remains moderate aeuro cent follow examinations considered bosniak iif bosniak cysts aeuro cent data influence reader experience inter reader variability insufficient aeuro cent technical standards publication year influence diagnostic performance
background number different viral bacterial fungal protozoan organisms cause atypical pneumonia three common chlamydia pneumoniae legionella pneumophila mycoplasma pneumoniae atypical pneumonias far underdiagnosed underreported clinical entities studies reported india study conducted march september determine seroprevalence pneumoniae chlamydia pneumoniae legionella pneumophila antibodies patients lower respiratory tract infections compare igm elisa sanger sequencing sequencing proved one rapid sensitive specific method diagnosis cases materials methods cross sectional hospital based study done government general chest hospital erragadda hyderabad study population included patients attending outpatient department admitted inpatients march september high probability atypical pneumonia based clinical symptoms signs like fever cough dyspnoea headache crepitations presence new pulmonary infiltrates chest ray cases like copd acute exacerbation bronchial asthma acute exacerbation community acquired pneumonia cases sputum serum samples collected patient blood samples collected subjected elisa detect igm antibody euroimmun chlamydia pneumoniae legionella pneumophila mycoplasma pneumoniae sputum samples showing pathogenic organisms npo subjected pcr amplification region sma followed sanger sequencing results cases positive igm antibodies atypical bacteria cases positive sanger sequencing common presenting symptoms cough fever chest pain dyspnoea headache number cases detected community acquired pneumonia patients followed copd bronchial asthma acute exacerbation conclusion igm elisa correlated clinically reasonable sensitivity could useful tool diagnosing atypical pneumonia caused pneumophila pneumoniae pneumoniae sanger sequencing comparisons low sensitivity although highly specific recommended application discriminating species diagnosis sputum samples
background prior studies shown treatment gap oral anticoagulation oac use among patients atrial fibrillation yet incompletely characterized factors associated failure treat subsequent outcomes contemporary practice methods using data collected june august ambulatory care sites outcomes registry better informed treatment atrial fibrillation identified factors associated absence oac via stratified logistic regression using weighted cox regression assessed association oac non use subsequent outcomes years results among patients oac among oac nonrecipients cha vasc score factors independently associated oac non use included atrial fibrillation type paroxysmal odds ratio confidence interval persistent permanent reference new onset left atrial diameter enlargement mild moderate severe reference normal diameter age years untreated patients higher risk death adjusted hazard ratio lower bleeding risk adjusted nonsignificant trend toward higher risk stroke non central nervous system embolism transient ischemic attack treated adjusted conclusions majority atrial fibrillation patients treated oac current community practice meet guideline indications treatment atrial fibrillation burden chronicity comorbidity associated nontreatment untreated patients increased risk adverse outcomes published elsevier inc
nowadays environmental protection become valuable asset entire society information based society provide efficient solutions risks mitigation already place complex infrastructures used monitor control natural environment lower interdependency solution gain integration level represented smart cities concept study present approach used integrate almost every existing system related environmental monitoring control one common view required order quickly integrate produced data commands control instruments main big data stream result ability solve environmental specific issues increased due superior analytical ability
series cerium zirconium mixed oxides doped alkaline earth metals prepared calcining mixture nitrate salt alkaline earth metals results ray diffraction raman spectroscopy analytical electron microscopy indicated alkaline earth compounds dispersed surface doped mixed oxides evaluated catalytic reaction solid coke tight contact conditions vol vol using thermogravimetric analysis coke oxidation weight loss first order coke measured first order rate constant proportional total surface area catalyst low catalyst loadings coke gasification weight loss nearly zero order coke measured areal reaction rate independent total surface area catalyst low catalyst loadings addition alkaline earth metals inhibited coke oxidation dioxygen promoted coke gasification steam elsevier rights reserved
background serum testosterone deficiency increases aging age also major risk factor prostate cancer prca pca tumors frequently diagnosed among men years old evaluated relationship preoperative serum testosterone clinical pathological features prca middle aged elderly patients methods total prca patients underwent robotic assisted radical prostatectomy september january university pennsylvania serum testosterone levels measured using elecsys testosterone immunoassay included irb approved protocol androgen deficiency determined serum free testosterone total testosterone demographic clinical tumor characteristics men low normal compared using test chi square tests logistic regression used determine associations clinical pathological variables levels results among middle aged men years low low average higher bmi years difference prostatectomy specimens prca patients low normal conclusion among men aged years low serum pretreatment predicted aggressive features prca prostatectomy specimens middle aged patients low testosterone levels measured pre operatively may indicate aggressive disease parameters asian pacific prostate society published elsevier korea llc
aim compare age related morbidity mortality transjugular intrahepatic portosystemic shunts tips methods performed retrospective chart review patients underwent tips university california los angeles medical center elderly patients older matched nonelderly patients controls model end stage liver disease meld score indication tips refractory ascites variceal bleeding serum sodium level ratio endpoints measures hospital stay post tips rifaximin lactulose use tips failure days readmission days meld days mortality days results total patient matches included study control elderly patients median interquartile iqr meld scores controls elderly controls elderly patients significant differences serum sodium indication tips thirty day follow laboratory test results also similar elderly control patients event free survival days similar controls elderly patients odds ratio confidence interval trend toward greater hospitalization mortality conclusions results study suggest event free survival similar nonelderly elderly patients although statistically significant tendency toward greater mortality hospitalization elderly
freshly harvested processing tomatoes california commercial fields surveyed mold species present mature fruit molds recovered majority fruit visual symptoms black mold decays quarter randomly sampled asymptomatic fruit alternaria fusarium geotrichum spp commonly recovered fungi symptomatic random samples based pairwise statistical analysis frequencies different fungal genera composite sample general statistically independent events exception weak association incidence geotrichum alternaria cladosporium stemphylium mold genera distribution data study provide processing tomato industry valuable informational resource used management fungal infection crop final thermally processed finished product relative abundance fungi survey supported development genera specific immunochromatographic diagnostic assays detect quantify mold occurrence californian processing tomatoes potential alternative current subjective visual methods characterized imprecision nonuniform species sensitivity simulation million composite samples based upon distributional survey data projected multiantibody immunochromatographic assay using monoclonal antibodies alternaria cladosporium fusarium geotrichum could successfully detect presence mold moldy processing tomato samples collected randomly harvest
although intimate partner violence ipv prevalent among women living hiv negatively impacts health studies examined ability aids service organisations asos address ipv study used qualitative approach identify facilitators barriers addressing ipv female clients asos united states depth interviews conducted march august aso staff members female clients reported current past history ipv interviews audio recorded transcribed analysed using constant comparative method data identify barriers addressing ipv organisation provider client levels include suggestions clients providers improving access care client provider suggestions differed areas providers emphasised structural changes increased training ipv provided organisation clients highlighted importance trusting personal relationships staff increase client disclosure ipv experiences given differing opinions clients staff asos consider involving women histories ipv process programme policy development asos unique opportunity provide comprehensive holistic care addressing ipv extent asos able recognise address ipv strategies increasing ability warrant greater attention funders aso administrators researchers
background sustain long lasting beneficial effects allergen specific sublingual immunotherapy slit adequate duration treatment required nevertheless many patients discontinue prematurely therefore fail obtain satisfactory therapeutic effect clinical practice aim study analyze causes leading premature discontinuation slit allergic rhinitis provide corresponding countermeasures following slit course methods performed retrospective analysis data patients started slit period december february patients contacted months slit part standard care patients claimed stopped treatment asked provide reason one phone calls results overall patients terminated immunotherapy first year treatment among patients following reasons cited nonadherence immunotherapy patients could reached ineffectiveness long course improvement symptoms side effects lack confidence treatment reasons conclusion fifty four percent patients terminated treatment within first year slit top reasons treatment discontinuation included patients reached ineffectiveness length course ars aaoa llc
exhaust gas internal combustion engine provides favorable conditions waste heat recovery whr system highest potential achieved rankine cycle heat recovery technology experimental studies investigate full scale systems using water based working fluids effects performance operation rankine cycle heat recovery system paper discusses experimental results practical challenges whr system utilizing heat exhaust gas recirculation system truck engine results showed boiler pinch point necessitated trade offs maintaining adequate boiling pressure achieving acceptable cooling egr superheating water expander used system geometric compression ratio together steam outlet timing caused high compression inlet pressures bar therefore required stable expander power output high pressures increased pump power reduced egr cooling boiler pinch point effects simulations indicated reducing expander compression ratio would allow lower steam supply pressures without adversely affecting expander power output
grid connected inverter indispensable photovoltaic power generation smart grid systems must designed stable operation impedance method based nyquist criterion often utilized analyze stability grid connected inverter systems impedance method based eigenvalues product inverter output admittance line impedance matrices frequency domain however frequency characteristics far derived inverters analog control systems new frequency analysis method inverters digital control systems proposed paper first stability analysis example three phase lcl type inverter controlled digitally shown results compared validated simulation using saber simulator finally also compared validated experimental results digitally controlled dsp based system wiley periodicals inc
paper assesses feasibility determining key household characteristics based temporal load profiles household electricity demand known household characteristics behaviours routines drive number features household electricity loads ways currently fully understood roll domestic smart meters elsewhere could enable better understanding collection high temporal resolution electricity monitoring data household level data affords tremendous potential invert established relationship household characteristics temporal load profiles rather use household characteristics predictor loads observed electricity load profiles indicators based could instead used impute household characteristics micro level imputed characteristics could aggregated small area level produce census like small area indicators work briefly reviews nature current future census taking outlining household characteristics found census also known influence electricity load profiles presents descriptive analysis large scale smart meter like dataset half hourly domestic electricity consumption reviewing correlation household attributes electricity load profiles paper reports results multilevel model based analysis relationships work concludes number household characteristics kind found census derived small area statistics may predicted particular load profile indicators discussion steps required test validate approach wider implications census taking also provided authors published elsevier ltd
coated thermoelectric refrigeration means infrared stealth target study infrared characteristic target coated thermoelectric refrigeration foundation infrared stealth technology coated thermoelectric refrigeration infrared characteristic model target coated thermoelectric refrigeration established considering complex energy exchange target sea structure transfer character thermoelectric refrigeration analyze effect current hot side transfer coefficient surface temperature target making corresponding program depending target background temperature consistent standard ideal current day designed
nanoparticles nps gained great attention owing interesting plasmonic properties efficient catalysis visible light irradiation study based plasmonic catalyst supported mesoporous silica isolated tetrahedrally coordinated single site oxide moieties namely sba designed purpose utilizing broad spectral range solar energy sba support allows deposition small nps narrow size distribution chemical structure morphology optical properties prepared catalyst characterized techniques vis extended ray absorption fine structure ray photoelectron spectroscopy field emission sem tem physisorption studies catalytic activity sba hydrogen production ammonia borane hydrolysis significantly enhanced comparison sba without oxide moieties tio sba involving agglomerated tio dark light irradiation improved electron transfer light irradiation caused creation heterojunctions nps oxide moieties explains results obtained present study
role hyaline hairs thallus brown algae genus fucus long debated several functions proposed used novel motorized set two dimensional three dimensional mapping microsensors investigate spatial heterogeneity diffusive boundary layer dbl flux around single multiple tufts hyaline hairs thallus fucus vesiculosus flow major determinant dbl thickness higher flow decreased dbl thickness increased flux algal thallus surrounding seawater however topography dbl varied directly follow contour underlying thallus areas around single tufts hyaline hairs exhibited complex mass transfer boundary layer showing increased decreased thickness compared areas smooth thallus surfaces thallus areas several hyaline hair tufts overall effect apparent increase boundary layer thickness also found indications advective transport driven pressure gradients vortex shedding downstream dense tufts hyaline hairs could alleviate local mass transfer resistances mass transfer dynamics around hyaline hair tufts thus complex hitherto assumed may important implications algal physiology plant microbe interactions
article describes new open source scientific workflow system timestudio project dedicated behavioral brain sciences program written matlab features graphical user interface dynamic pipelining computer algorithms developed timestudio plugins timestudio includes set general plugins reading data files modifying data structures visualizing data structures etc set plugins specifically developed analysis event related eyetracking data proof concept possible create custom plugins integrate new existing matlab code anywhere workflow making timestudio flexible workbench organizing performing wide range analyses system also features integrated sharing archiving tool timestudio workflows used share workflows data analysis phase scientific publication timestudio thus facilitates reproduction replication scientific studies increases transparency analyses reduces individual researchers analysis workload project website http timestudioproject com contains latest releases timestudio together documentation user forums
columbine high school shooting prompted school officials policy makers create implement programs policies would prevent violence school ensure school safety ten years passed since columbine shooting however debates concerning risk factors shootings continue ensue focus article examine columbine school shootings within context bronfenbrenner ecological systems analysis examine commonly identified risk factors operate within five systems levels chrono macro exo mesa microsystems draw implications school based practice policy elsevier ltd rights reserved
backgroundparents intellectual developmental disabilities idds represented child welfare cases although per invalid indicator parenting abilities study examined prevalence judicial consideration parental test evidence appellate cases methodsthe present authors conducted boolean searches westlaw corporation case database since present authors used six question checklist survey recent american appellate cases involving termination parental rights tpr decisions included evidence parental intellectual developmental disabilities based resultsin cases parental low presented barrier parenting competence higher courts uphold tpr decision cases involving parents intellectual developmental disabilities conclusionsparental scores routinely relied upon judge parenting capacity custody cases parents intellectual developmental disabilities present authors recommend comprehensive assessments examining broader range contextual variable may impact parenting abilities
macroautophagy autophagy herein cellular stress response survival pathway responsible degradation long lived proteins protein aggregates well damaged organelles order maintain cellular homeostasis consequently abnormalities autophagy associated number diseases including alzheimers disease parkinson disease cancer according current view autophagy seems serve tumor suppressor early phases cancer formation yet later phases autophagy may support facilitate tumor growth spread contribute treatment resistance therefore autophagy considered stage dependent dual player cancer micrornas mirnas endogenous non coding small rnas negatively regulate gene expression post transcriptional level mirnas control several fundamental biological processes autophagy exception furthermore accumulating data literature indicate dysregulation mirna expression contribute mechanisms cancer formation invasion metastasis affect responses chemotherapy radiotherapy therefore considering importance autophagy cancer biology study autophagy regulating mirna cancer allow better understanding malignancies lead development novel disease markers therapeutic strategies potential provide study cancer related mirnas also implicated autophagy regulation review focus autophagy mirna cancer connection discuss implications cancer biology cancer treatment
background aim ledipasvir sofosbuvir led sof treatment patients infected genotype hepatitis virus used without ribavirin rbv rbv well known promote significant adverse events aim study compare efficacy safety treatment led sof without rbv patients infected hepatitis virus genotype methods performed systematic review followed pairwise meta analysis including randomized controlled trials reported efficacy rapid virological response sustained virological response weeks post treatment svr viral relapse safety outcomes serious discontinuation owing anemia rash performed subgroup analysis evaluating svr including cirrhotic patients results reported risk ratios confidence intervals results seven randomized controlled trials analyzed led sof rbv showed worse safety profile compared led sof without rbv following outcomes anemia rash significant differences observed regarding serious rapid virological response svr svr viral relapse subgroup analysis show significant differences either treatment groups conclusion administration led sof rbv treatment naive patients without cirrhosis non cirrhotic treatment experienced patients promote significant additional benefits furthermore still unclear whether cirrhotic treatment experienced patients could benefit combined therapy
paper presents conceptual design control novel gasoline direct injector gdi using giant magnetostricitve material terfenol actuation component electromagnetic fluid analyses accomplished investigate influence parameters nozzle length pressure input fuel cone angle injector needle experimental results obtained fabricated gdi show good agreement numerical results provided finite element analysis furthermore fabricated gdi controlled fuzzy pid controllers shown fuzzy controllers provide faster response less accuracy compared pid controller consequently tradeoff fast response steady state error selecting propoer controller
context hypericum perforatum commonly known john wort practised alternative medicine depression conversely remedial efficacy indulged various adverse effects recuperated formulating nanoscaled commercial capsules encased biopolymer chitosan potential application nanoencapsulation regards polymer enhances slow controlled release targeted drug achieve desired delay right stimulus obtained aims value synthesizing biopolymeric nanocomposites encapsulating john wort commercial capsules substantiating study animal model depression endorse effect nanocapsulated drug effective brain drug methods nanoparticulated suspension prepared ionic gelation technique characterized attest antidepressant activity vivo studies results drug binding efficiency endorsed studies nanoparticles characterized average particle size positive zeta potential animal despair studies depression induced mice models displayed significant difference immobility time force swimming tail suspension test commercial capsules administed orally animal despair studies substantiated affirmative biochemical assessments like sod cat gsh lpo compared control groups conclusions outcomes work manifest calibre john wort nanocomposites lower dosage alleviate depression reduce side effects
heating groundwater thermal energy storage tes poses potential formation separate gas phase necessary boundary conditions potential effects monitoring feasibility process focused within previous studies since formation gas phase could change groundwater flow conditions hydrochemistry porous media properties thus efficiency tes applications improved understanding process needed temperature percolated sediment column tests adjusted degrees quantify temperature induced physical gas phase formation effect electrical resistance gas phase formation accumulation effects hydraulic conductivity heat conductivity heat capacity investigated using scenario calculations based closed loop borehole tes system degrees different geochemical conditions experimentally quantified degassing ratios within expected range thermodynamic calculations laboratory time lapse electrical resistivity measurements proofed suitable tool identify onset location gas phase formation depending geochemical conditions hydraulic conductivity area simulated heat storage site decreased one order magnitude consequence degassing within scenario calculations heat conductivity heat capacity decreased maximally respectively results indicate gas phase formation result aquifer heating pronounced effects especially groundwater flow conditions therefore considered particularly nearly fully gas saturated groundwater aquifers containing gas sources
paper presents voltage mode first order pass filter using one differential difference current conveyor ddcc active element resistor capacitor one passive elements proposed circuit realizes first order pass functions without component matching constraints hence phase shifted signal whole range may obtained simultaneously new sinusoidal oscillator circuit designed ddcc based pass filter proposed circuit performance tested using pspice software simulation mietec cmos model parameters non ideal analysis also performed
majority investigations rainwater harvesting focused sizing potential water savings including studies proposing different methods estimating rainwater tank outcomes several studies used monthly rainfall data estimate rainwater tank outcomes however quantification using daily rainfall data much accurate compared using monthly rainfall data vast majority works using daily rainfall data used daily water balance model analysis studies using daily water balance model used historical rainfall data calculated water savings many years presented average calculated years total outcome raintank analyser tool uses methodology widely used used south australian policy makers producing relevant design charts contrast etank daily water balance model developed produce potential rainwater savings augmented townwater supply tank overflow reliability payback period three distinct climate conditions dry average wet years paper presents comparison etank calculated potential water savings calculated raintank analyser similar conditions rainfall station central adelaide general raintank analyser produced water savings close etank calculated water savings average year however etank produced potential water savings dry wet years found significant climatic variations exist magnitudes climatic variations different scenario presented assess spatial variability three rainfall stations different regions adelaide metropolitan selected etank used calculated potential water savings three climatic conditions dry average wet years various combinations roof tank sizes found depending input variable conditions tank size roof area climate significant spatial variations exist within regions also found potential water savings depends total rainfall amount particular area also input conditions similar conditions area lower annual rainfall may provide higher water savings due rainfall pattern elsevier rights reserved
polybenzoxazine coatings applied spin coating solution prepared laboratory synthesized phenol para phenylenediamine benzoxazine ppda aluminum alloy heat treatment performed coating polymerize benzoxazine monomer ring opening mechanism attested fourier transform infrared spectroscopy followed differential scanning calorimetry dsc dielectric analysis dea showed curing proceed temperature range degrees without thermal decomposition taking place already reported literature commercial bisphenol benzoxazines barrier protection evaluated electrochemical impedance spectroscopy eis days sodium chloride solution results fitted equivalent electrical circuits order understand electrochemical behavior system initial barrier properties precursor polymerized coatings appear excellent coatings thickness though delamination occurs polymerized coating saline tests several days immersion kind coatings remarkable properties respect epoxy coatings show high geometrical stability curing low water uptake saline tests elsevier rights reserved
kidney transplant recipients ktr subjected immunosuppressive therapy enhance hepatitis virus replication leading cirrhosis hepatocellular carcinoma hcc aim study assess prevalence outcome hcc ktr case control study patients chronic hbv hcv infection underwent kidney transplantation subsequently developed hcc compared control group patients chronic hbv hcv infection matched gender age hcc diagnosis receive kidney transplantation among ktr hepatitis fourteen developed hcc period prevalence age hcc diagnosis years controls time transplantation hcc diagnosis years six hccs related hbv six hcv two infection hbv hcv immunosuppressive therapy comparable hbv hcv hbv hcv patients diagnosis patients met milan criteria control group alpha fetoprotein levels tumour characteristics treatment modalities comparable groups patient survival years hcc diagnosis ktr compared controls survival hcc diagnosis significantly worse ktr compared nontransplanted patients hbv hcv prevention crucial based viral eradication suppression transplantation
chronic acth excess leads chronic cortisol excess without escape phenomenon resulting cushing syndrome excess adrenal androgens also occur females overcompensate gonadotrophic loss inducing high testosterone males compensate inducing low testosterone chronic acth excess leads chronic adrenal mineralocorticoid excess low aldosterone levels acute rise aldosterone plasma levels resume low values days acth prolonged two mineralocorticoids man cortisol deoxycorticosterone doc zona fasciculata escape long term effect chronic acth excess secretion rates remain elevated parallel concomitant rise cortisol doc compensate loss aldosterone eventually create state chronic mineralocorticoid excess best evidenced accompanying suppression renin plasma levels contribution suppression aldosterone secretion prolonged vivo stimulation acth leads increase total adrenal protein rna synthesis cell proliferation indicated increase total dna resulting adrenocortical hyperplasia participates amplified response chronically stimulated gland weight gland greatly increased growth stimulatory effect acth vivo likely proceeds activation local complex network autocrine growth factors receptors number compounds including non acth proopiomelanocortin peptides msh shown exert adrenocortical growth effect
statistical inference subject nonnegativity constraints frequently occurring problem learning problems nonnegative least mean square nnlms algorithm derived address problems online way algorithm builds fixed point iteration strategy driven karush kuhn tucker conditions shown provide low variance estimates however suffers unbalanced convergence rates estimates paper address problem introducing variant nnlms algorithm provide theoretical analysis behavior terms transient learning curve steady state tracking performance also introduce extension algorithm online sparse system identification monte carlo simulations conducted illustrate performance algorithm validate theoretical results elsevier rights reserved
paper deals control strategies mitigation unwanted vibrations typical medium long span cable supported bridges aiming underline general observations side effects related adoption different control strategies two finite element models medium long span bridges namely suspension cable stayed bridge developed simulating structural response wind earthquake excitation passive semi active control strategies implemented models mitigating dynamic effects control schemes designed wind excitation suspension bridge seismic excitation cable stayed bridge attention initially focused high intensity loading conditions low probability occurrence control strategies arrangements assessed changing input intensity addition cross check performed addressing earthquake actions suspension bridge wind forces cable stayed bridge results also analysed terms indirect effects fatigue damage
graph coloring generic sense used identify subsets independent tasks parallel scientific computing applications traditional coloring heuristics aim reduce number colors used number also corresponds number parallel steps application however color classes produced skew sizes utilization hardware resources becomes inefficient especially smaller color classes equitable coloring theoretical formulation coloring guarantees perfect balance among color classes practical relaxation referred balanced coloring paper consider balanced coloring models context parallel computing goal achieve balanced coloring input graph without increasing number colors algorithm oblivious balance would used propose study multiple heuristics aim achieve balanced coloring two variants coloring problem distance coloring standard coloring problem partial distance coloring defined bipartite graph present parallelization approaches multi core manycore architectures cross evaluate effectiveness respect quality balance achieved performance furthermore study impact proposed balanced coloring heuristics concrete application viz parallel community detection example irregular application addition propose several extensions basic balancing schemes evaluate balancing efficacy performance characteristics thorough treatment balanced coloring presented paper algorithms application expected serve valuable resource parallel application developers seek improve parallel performance applications using coloring
chromophores materials exhibit nonlinear absorption broad spectrum high temporal dynamic range interest application materials engineering biology recent work number research groups led development new family organometallic chromophores materials featuring interesting useful nonlinear absorption properties systems contain platinum acetylide moiety fundamental molecular unit combined delocalized conjugated electron systems organometallic chromophores provide unique combination properties negligible ground state absorption visible region large spin orbit coupling giving rise high triplet excited state yield triplet lifetime microsecond domain high two photon cross section visible near infrared regions high triplet triplet absorption cross section visible near infrared region spotlight application highlights recent developments area combining background review nonlinear absorption platinum acetylide chromophores describing significant recent results laboratory
model driven engineering mde search based software engineering sbse relevant approaches software engineering mde aims raise level abstraction order cope complexity software systems sbse involves application metaheuristic search techniques complex software engineering problems reformulating engineering tasks optimization problems purpose paper survey relatively recent research activity lying interface two fields area come known search based model driven engineering begin introduction mde concepts models metamodels model transformations also give brief introduction sbse metaheuristics survey current research work centered around combination search based techniques mde literature survey accompanied presentation references details
background framingham stroke risk score fsrs well regarded risk appraisal tools evaluating individual absolute risk stroke onset however several widely accepted risk factors stroke included original framingham model study proposed new model combines existing risk models new risk factors using synthesis analysis applied longitudinal atherosclerosis risk communities aric data set methods risk factors original prediction models new risk factors proposed model discussed three measures like discrimination calibration reclassification used evaluate performance original framingham model new risk prediction model results modified statistics hosmer lemeshow test classless nri class nri statistical indices respectively denoted performance discrimination calibration reclassification evaluating newly developed risk prediction model stroke onset showed new stroke new stroke risk score prediction model model higher modified statistics smaller hosmer lemeshow chi square values recalibration original fsrs model classless nri class nri new stroke model original fsrs model significantly positive overall group conclusion new stroke integrated seven literature derived risk factors outperformed original fsrs model predicting risk score stroke illustrated seven literature derived risk factors contributed significantly stroke risk prediction
recent years number studies conducted analyze wind induced vibrations bridge using computational fluid dynamics cfd previous studies limited analyzing two dimensional sections three dimensional analyses entire bridges yet performed study cfd program fluid structure interaction developed perform buffeting analysis cable stayed bridge fem formulated galerkin least squares method arbitrary lagrangian eulerian method used perform fluid structure interaction cfd spectral representation method used generate time series turbulence applied inlet boundary condition supercomputer used reduce large computing time analysis model existing cable stayed bridge contains ambient atmospheric region used calculate dynamic responses bridges detailed flow wind results cfd analysis bridge compared results conventional frequency domain buffeting analysis results essentially good agreement conventional analysis numerical method developed study efficient alternative wind tunnel tests verifying wind flow wind loading structural vibrations american society civil engineers
upgraded version athas sub channel code athas developed investigation thermal hydraulic behavior nuclear reactor core ocean environment consideration heaving rolling motion effect code verified another modified sub channel code based cobra used analyze thermal hydraulic characteristics typical smr heaving rolling motion condition calculation results show heaving rolling motion affect thermal hydraulic behavior reactor significantly elsevier ltd rights reserved
mammals relationship reproductive function health particularly difficult define previously old postreproductive aged mice replacement senescent ovaries new ovaries young actively cycling mice increased life span hypothesized factors increased life span would also influence health span current experiments tested two seven domains function health sensory function cognition determine exposure postreproductive female mice young transplanted ovaries influenced health span evaluated control female cba mice six months age additional mice received new ovaries months age subsequently evaluated months age respectively evaluation sensory function included two measures olfactory perception olfactory identification buried pellet test olfactory discrimination novel recognition block test found significant age related decline olfactory identification month old mice decline avoided ovarian transplantation months age olfactory discrimination block test revealed age associated increase time spent novel familiar blocks trend reversed month old new ovary recipients evaluated cognitive behavior burrowing behavior test detected significant age related decrease burrowing behavior months age age related decrease burrowing behavior prevented ovarian transplantation months age summary shown cognitive behavior sensory function negatively influenced aging positively influenced restored establishment active ovarian function aged female mice findings provide strong incentive investigation positive influence young ovaries restoration health postreproductive females elsevier inc rights reserved
space solar power station ssps comprehensive system continuously collects solar energy space transmits ground wireless power transmission wpt system systems great potential provide large scale energy increase efficiency reduce weight cost photovoltaic components huge light weighted concentrator introduced latest ssps concepts integrated symmetrical concentrator isc arbitrarily large phased array alpha however typical ssps running geostationary earth orbit geo sunlight direction varies time leading great challenge concentrator design isc two dimensional mast used realize sun tracking however multi thousand ton structure difficult control precisely space reason alpha comprises large number individually pointed thin film reflectors intercept sunlight mounted non moving structure however real time adjustment thousands reflectors still open problem furthermore uniformity time power generation utpg another factor evaluating system therefore paper proposes novel concentrator based zero index metamaterial zim called thin film energy terminator ssps tent aid control massive reflectors avoiding rotation overall system control massive reflectors influence obliquity ecliptic also optimization design method proposed increase solar energy collecting efficiency ece flux distribution ray tracing simulation results show ece day terms uniformity varies compared alpha utpg stable cospar published elsevier ltd rights reserved
fragile states raising increasing concern among donors since mid policies global fund fight hiv aids malaria tuberculosis excluded fragile states source provided financing countries according standardized procedures represent interesting cases exploring meaning role measurement globalized context measurement field hiv aids treatment given rise private outsourcing expertise auditing thereby creating new form value based social process registration creation realities produced intervention scriptural economies must questioned terms production knowledge also terms social justice governing hiv aids treatments numbers fragile state explored article experience central african republic car terms epidemiology access antiretroviral drugs unexpected effects performancebased programs context underline need global health governance embedded social justice framework
main aim paper identify personal factors salesman relevant achieving sales success second aim categorize verbal nonverbal communication personal sales process taken account fact every level different significant person last task current research determine differences men women perception personal sales process data collected research conducted czech republic respondents respondents rated personal factors salesman verbal nonverbal communication within videos played respondents data current research analysed via factor analysis conceptual model personal selling adapted czech republic regard cross cultural differences
speech therapy become efficient tool bring back proper speech patients suffering various speech disorders patients benefitted speech therapy session interactive visible change environment hence proposed system aims manipulating devices user input correct also indicates user input incorrect speech recognition done using concept linear predictive coding arduino uno board used hardware interface
one electron transfer oxidation long proposed route ultimate electrophilic carcinogenic metabolites methylated non methylated polycyclic aromatic hydrocarbons pah carcinogenic hydrocarbon methylcholanthrene methyl analogous function meso anthracenic center form dimethylene bridge treatment compound one electron transfer oxidizing reagent ferric ferricyanide iii iii mixed aqueous organic media generated multiple oxygenated species many duplicate found mammalian metabolism including known carcinogens hydroxy keto results agreement unified theory pah carcinogenicity predicts vivo generation proximate benzylic alcohol metabolite procarcinogen conjugation moiety sulfate intended rapid urinary excretion sulfate instead acts leaving group generates electrophilic carbocation capable reacting sensitive nucleophiles dna cellular nuclei products one electron transfer oxidation align well predictions unified theory since many cases products provide substrates precursors conjugation reactions elsevier rights reserved
paper presents explicit computationally efficient recursive formula computing normal forms center manifolds nonlinear transformations general dimensional systems associated semisimple singularities based formula develop maple program convenient end user needs prepare input file execute program automatically generate result several examples presented demonstrate computational efficiency algorithm elsevier rights reserved
objectives aim evaluate endocrine metabolic thyroid parameters could help explore relationship thyroid function metabolic changes chinese polycystic ovary syndrome pcos patients methods within prospective study pcos patients compared healthy women thyroid parameters assessed well changes endocrine metabolic clinical characteristics results pcos patients normo ovulatory women matched age controls included significant increases thyroid stimulating hormone tsh total triiodothyronine total thyroxine pcos patients body mass index bmi waist hip ratio whr luteinizing hormone follicle stimulating hormone fsh total testosterone significantly higher pcos compared controls total cholesterol cho triglycerides apolipoprotein apob levels pcos higher whereas high density lipoprotein hdl apolipoprotein apoa lower compared controls insulin homeostatic model assessment insulin resistance homa significantly higher patients pcos conclusions study confirms well known negative metabolic changes pcos patients small increases tsh level may related metabolic changes pcos patients studies may improve understanding relationship thyroid function metabolic changes
need reduce greenhouse effect using distributed energy resources significantly increased recent years particularly advent deregulated market climate changes cause large swings output power renewable resources resulting fluctuations frequency islanded microgrid increase performance wide range power system operating conditions energy management system proposed based fuzzy fractional order proportional integral derivative pid ffopid controller able analyze simulate dynamic behavior grid connected mgs controller proposed encompassing distributed generation resources plug play ability performance ffopid controller verified frequency control purposes support internal bus voltage islanded grid connected operating modes accordance failure time energy storage used improve system dynamic response reduce distortion provide damping frequency oscillations caused renewable resources energy storage overload capacity utilized rapid initial control frequency achieve goal energy management system based fuzzy decision mechanism combined pid controller ffopid implemented according characteristics limitations overloading state charge obtained results show good performance ffopid controllers improving transient stability following fault caused islanded operation simulation results validated effectiveness ffopid controllers system several scenarios superior stabilization robustness comparison fuzzy logic pid flpid controller pid controller copyright john wiley sons ltd
paper discusses application dynamic methods damage detection main cables suspension bridges using data continuously recorded wind excitation permanent monitoring systems automated operational modal analysis continuum model predicting vertical aeroelastic response wind excited damaged suspension bridges formulated presented first model shows real sample bridge typical variations mean wind speed produce variations natural frequencies due aeroelastic effects significant produced small damage possible solution issue proposed paper consists removing dependence excitation source calculating frequency shifts considering frequencies reference damaged states associated approximately mean wind speed task necessary estimation frequency shifts statistical analysis identified natural frequencies outline need continuous dynamic monitoring analytical model finally employed generating dynamic wind response data successively processed means advanced auto mated modal identification tool although based simplifications inherently contained analytical model results show frequency shifts caused relatively small damage accurately estimated response data recorded wind excitation reasonable number data sets
network systems world fragile come attack source attack denial service dos state another type threat keep networks safe intrusion detection prevention systems idps constantly monitor network traffic malicious threat detected threat blocked reported analysis however every defensive system must always type weakness false negatives false positives examples idps fail protect network another instance skilled attacker may employ direct kernel object modification dkom trick idps detecting malicious activities idps strong yet strong enough paper presents hybrid solution incorporates signature anomaly based systems detect prevent malicious attacks intensifying cataloged include common anomalies baselines used signature based systems also propose improvement framework current host idps network using signature anomaly based methodologies implementing hybrid vmm based honeypot theorized self healing hybrid idps boost advantages efficiency accuracy authors published elsevier
article describes construction gemtec global empirical model total electron content ionosphere designed satellite radio navigation model based total electron content maps gps system measurements input data filtration compression performed natural orthogonal functions expansion method suggested model provides accurate ionospheric delay compensation propagation radio signals comparison standard model recommended interface control document gps systems elsevier ltd rights reserved
risperidone one active metabolites paliperidone widely used treatment schizophrenia used patch clamp study investigate effects paliperidone herg potassium channels expressed hek cells western blot analyses used study effects risperidone paliperidone herg herg isoform channel trafficking risperidone paliperidone inhibited herg tail currents concentration dependent manner values respectively block herg currents paliperidone voltage dependent increasing range voltages channel activation fast application paliperidone inhibited herg current elicited depolarizing pulse fully inactivate herg currents suggesting inactivated state block fast application paliperidone repolarization reversibly inhibited herg tail currents concentration dependent manner value kinetic analysis paliperidone interaction open state herg channels showed rate constants association dissociation paliperidone respectively paliperidone shifted steady state inactivation curve herg currents hyperpolarizing direction also produced use dependent block risperidone paliperidone effect herg herg channel trafficking cell membrane results indicated paliperidone inhibited herg current preferentially interacting open inactivated states channel disruption herg channel protein trafficking
background fourth round critical assessment small molecule identification casmi contest www casmi contest org held two new categories automated methods article covers challenges categories without metadata organization participation results postcontest evaluation casmi perspectives future contests small molecule annotation identification results input output kernel regression csi iokr machine learning approach performed best category best automatic structural identification silico fragmentation team brouard challenge wins winner category best automatic structural identification full information team kind msfinder challenge wins best methods able achieve top ranks category methods ranking correct candidate top around challenges success rate rose top ranks category candidates top challenges machine learning chemistry based approaches shown perform complementary ways conclusions improvement semi automated fragmentation methods small molecule identification substantial achieved high rates correct candidates top top despite large candidate numbers open great possibilities high throughput annotation untargeted analysis known unknowns high quality training data becomes available improvements machine learning methods likely continue alternative approaches still provide valuable complementary information improved integration experimental context also improve identification success real life annotations true unknown unknowns remain evaluated future casmi contests
solving unit commitment problem ucp optimizes combination production units operations determines appropriate operational scheduling production units satisfy expected consumption varies one day one month besides production unit conducted constraints render problem complex combinatorial nonlinear paper proposed new strategy based combination particle swarm optimization method genetic algorithm applied ieee electrical network buses containing production units solve unit commitment problem one side find optimized combination scheduling side leading minimize total production cost
due massive deployment electrical network devices fiber wireless fiwi access network suffer challenge high energy consumption ever increasing eager green communication infrastructure issue high energy consumption may become one major barriers advance fiwi access network previous works proposed green fiwi access network cover three aspects including optimized deployment network devices optical network units onus energy efficient bandwidth allocation onus qos guarantee dynamic power states scheduling onus active sleep according traffic profile however works take energy saving design wireless subnetwork account simultaneously fact onus optical subnetwork switched sleep states part radio interfaces originally forwarding traffic sleep onus would idle low loaded provides potential opportunity energy saving wireless subnetwork switching idle low loaded radios paper focuses design green multiradio fiwi access network integrating energy savings optical wireless subnetworks support energy efficient design new power states defined onus radios respectively aiming dynamic traffic profile heuristic algorithms proposed energy saving integrated wireless front end optical back end fiwi access network first energy saving algorithm onu sleep mechanism eas proposed dynamically schedule power states onus judging traffic profile load thresholds energy saving algorithm based radios ero proposed reconfigure topology wireless subnetwork controlling power states radios dynamically moreover wireless rerouting employed eas ero guarantee qos provisioning ability network finally comprehensive energy saving scheme called proposed combining eas ero algorithms strategically simulation results show reasonable setting parameters proposed scheme save energy wide range traffic load compared energy saving qos aware energy saving scenarios respectively
present magnetically actuated microfluidic transistor valve chip micro valve uses magnetorheological fluids micropatterned onto elastomeric membrane develop ultra compact solution digital control microfluidic circuits simulated micro valves theoretically also characterized micro fabricated devices experimentally simulated effects channel valve geometry deformability valve experimentally characterized effects channel valve geometry ability reversibly close channels fully characterized microfabricated valves flow rate range min among various kinds valves examined lower flow rates circular valves diameter width channel higher flow rates rectangular valves wide channel show best ability terms valve closure response time fabrication integration proposed valve compatible range polymer microfabrication technologies advantage simple fabrication small size external power requirement valve structures promising solutions pumping active flow control portable analytical instrumentation point care diagnostic devices even wearable microfluidic devices
paper aircraft wings simplified cantilever beam structure piezoelectric actuator used eliminate effects thermal environment mathematical modeling cantilever beam temperature field built simulation accessional control piezoelectric film model show feasibility control method preliminarily purpose enhance performance structures base general materials using smart material effective control methods future
previously reported women short sleep duration consumed dietary carbohydrate showed increased risk obesity compared slept adequately men using cross sectional study korean women investigated influence sleep duration obesity related variables consumption dietary carbohydrate rich foods relation menopausal status premenopausal women short sleep duration significantly greater body weight body mass index systolic diastolic blood pressures respectively prevalence obesity consumption carbohydrate rich foods staple foods simple sugar rich foods adequate sleep duration adjustment covariates premenopausal women short sleep duration obese times compared subjects adequate sleep duration confidence interval however obesity related variables dietary consumption odds obese differ according sleep duration postmenopausal women findings suggest increased risk obesity consumption dietary carbohydrate rich foods short sleep duration appeared disappear menopause korean women
social cognitive intervention developed delivered credit course improve mental distress university students based findings previous health survey showing notable mental distress among future teachers hungary intervention included increasing information psychoactive substances used stress reduction skills development stress reduction methods improving skills communication problem solving students participated previous health survey targeted mental status participants assessed questionnaire male mean age years male mean age years intervention specifically self efficacy outcome approximated trait measure sense coherence psychological distress measured item general health questionnaire goldberg validity two versions ghq study mental illness general health care psychological medicine intervention compared intervention psychological distress reduced among participants non significant improvement occurred mean score sense coherence mean points points intervention produced modest significant decrease psychological distress students cost per point improvement mental distress intervention first example translation social cognitive theory practice among students higher education integrated curriculum standardized optional course
majority wind turbines currently operation conventional danish concept design three bladed rotor turbines indirectly coupled electrical generator via gearbox recent technological developments enabled direct drive wind turbines become economically feasible potentially direct drive wind turbines may enjoy higher levels availability due removal gearbox design however theory far substantiated detailed analytic calculation providing calculation paper enables quantitatively evaluate technical economic merits direct drive gearbox driven wind turbines
backgroundmigraine common neurological disorder affects large proportion population norfolk island population genetically isolated population ideal discovery cohort genetic variants involved complex disease susceptibility given reduced genetic environmental heterogeneity given majority proteins responsible mitochondrial functionare nuclear encoded study aimed investigate role nuclear encoded mitochondrial protein nemp genes relation migraine susceptibility methodsa gene centric association analysis nemp genes undertaken related individuals within genetically isolated norfolk island population discovery phase included genes three snp associations investigated replication phase using unrelated migraine case control cohort patients controls resultsthe discovery phase study implicated snps nemp genes associated migraine susceptibility replication analysis validated implicated genes snps three nemp genes shown associated migraine replication cohort csnkg elovl sardh involved phosphorylation fatty acid metabolism oxidative demethylation respectively conclusionhere provide evidence variation nemp genes associated migraine susceptibility study provides evidence link mitochondrial function migraine susceptibility
background hashimoto thyroiditis common autoimmune thyroid disease may lead hypothyroidism due progressive destruction thyroid etiology unclear however associated multiple genetic predispositions consanguinity associated increased susceptibility different inherited conditions study investigated association consanguinity risk first time methods using case control study design patients compared two subject groups participants non hypothyroidism healthy control participants three groups age sex matched presence consanguinity among parents compared groups odds ratios calculated establish correlation results consanguinity significantly increased risk compared healthy subjects addition consanguinity significant risk factor compared non hypothyroidism patients however prevalence consanguinity significantly different non hypothyroidism patients healthy subjects conclusions results suggest risk increased consanguineous unions significant increase risk non hypothyroidism observed however precise risk estimates larger studies include different populations may helpful findings highlight health impact consanguinity applications empiric risk estimations genetic counseling particularly countries high rates consanguineous marriages
based cellular automata model meticulous two lane cellular automata model proposed driving behavior difference difference vehicles accelerations moving state starting state taken account furthermore vehicles motion refined using small cell one meter long accompanied coming traffic management measure two lane highway traffic model containing work zone presented road divided normal area merging area work zone vehicles different areas move forward according different lane changing rules position updating rules simulation found density small cluster length front work zone increases decrease merging probability suitable merging length appropriate speed limit value recommended simulation result form speed flow diagram good agreement empirical data indicates presented model efficient partially reflect real traffic results may meaningful traffic optimization road construction management elsevier rights reserved
order hemiptera includes jumping insects fastest takeoff velocities generated catapult mechanisms also contains large family miridae plant bugs analysed jumping strategies mechanisms six mirid species high speed videos anatomy propulsive legs conclude use different mechanism jumps powered direct contractions muscles three strategies identified first jumping propelled movements middle hind legs respectively longer front legs three species masses ranging depression coxo trochanteral extension femoro tibial joints accelerated body take velocities middle legs lost ground contact take hind legs generated final propulsion power requirements could met direct muscle contractions catapult mechanisms implicated second species combined leg movements wing beating generate take wing downstroke third four wingbeat cycles preceded take assisted leg movements take velocities reduced acceleration times lengthened species habitat jump lower take velocities achieved powering jumping direct muscle contractions may offset eliminating time taken load catapult mechanisms
paper presents mathematical model wind turbine includes permanent magnet synchronous machine pmsg real time simulations dynamic model considers stochastic model wind state space representation wind turbine pmsg avoiding use gear box back back converter interconnection system grid field oriented control technique reference frame used converter also control loop pitch angle wind turbine implemented order show performance controllers implemented arduino card connected specialized station real time simulations case studies show dynamic behavior wind turbine presented discussed
background widely agreed practices clinicians based best available research evidence often evidence reliably disseminated people make use know gap leads ineffective resource use suboptimal provision services especially problematic low middle income countries lmics face greater resource limitations family planning including intrauterine device iud use represents important area evaluate clinicians knowledge practices order make improvements methods questionnaire developed tested administered individuals china kazakhstan laos mexico participants responded ten questions assessing knowledge practices relating contraception iuds series questions used determine individual characteristics working context ordinal logistic regressions conducted knowledge practices dependent variables results overall response rate achieved respondents able correctly answer five knowledge testing questions self reported often undertaking four recommended clinical practices never performing one practice contrary recommendation statistically significant factors associated knowledge scores included masters doctorate degree often reading scientific journals high income countries significant factors associated recommended practices included training critically appraising systematic reviews training care patients iuds believing research performed country average excellent quality based facility operated ngo view higher quality available research important improving work conclusions analysis supports previous work emphasizing need improved knowledge practices among clinicians concerning use iuds family planning also identifies areas targeted interventions may prove effective assessing opportunities increasing education training programs clinicians research iud provision could prove particularly effective
aim prospectively investigate association bladder function nerve growth factor ngf concentration urine individuals neurogenic lower urinary tract dysfunction nlutd spinal cord injury sci methods individuals chronic sci nlutd presenting routine urologic examination tertiary urologic referral center recruited study patient characteristics current bladder evacuation method urodynamic parameters collected controls individuals normal bladder function recruited staff sci rehabilitation center urinary ngf concentration measured triplicates enzyme linked immunosorbent assay minimal sensitivity results data individuals normal bladder function nlutd respectively analyzed urinary ngf concentration investigated samples conclusions urinary ngf concentration differentiate individuals normal bladder function nlutd least patients sci urinary ngf concentration seem clinically relevant biomarker nlutd neurourol urodynam wiley periodicals inc
green buildings entirely successful achieving energy saving targets one way improving energy targets encourage occupants adopt energy saving behaviour date energy saving behaviour given less focus improving green building performance energy saving initiatives retrofitting buildings green features study uses comparison case studies green buildings conventional buildings new zealand better understand energy saving behaviour occupants questionnaires distributed occupants green conventional buildings evaluate extent energy saving behaviour practiced identify potential strategies encourage energy saving behaviour objective paper investigate level energy saving behaviour green conventional office buildings see people green buildings perform better energy saving behaviour people conventional buildings computer usage findings show better energy saving behaviour occupants green buildings occupants conventional buildings paper shows case recommended strategies encourage energy saving behaviour used different buildings also discussed strategies include raising education awareness energy efficiency among building occupants energy saving commitments active building manager assigned energy related matters
erap single nucleotide polymorphisms snp associated ankylosing spondylitis data erapsnps juvenile idiopathic arthritis jia scarce erap snp shown confer risk enthesitis related arthritis era category jia examined prevalence association snp indian children era snps erap genotyped children era ankylosing spondylitis healthy controls using taqman genotyping allele frequencies genotype frequencies calculated compared using cochran armitage test minor allele frequencies era healthy controls neither era patients showed significant association snp segregating according hlab status alter lack association snp erap confer risk developing era asian indian population
paper presents procedure include different cost scenarios raw materials design electric machines ratio performance material cost visualized number different cost scenarios thereby possible see specific design competitive current market circumstances also compare sensitiveness fluctuations material prices
operation traditional rectifiers half wave bridge rectifiers wireless power transfer applications may inefficient reduce amount power delivered load alternative use class resonant rectifiers known operate efficiently high resonant frequencies large input voltages class rectifiers near sinusoidal input current leads improved overall system performance increased efficiency especially transmitting coil driver paper first investigate use class resonant rectifiers wireless power transfer systems based resonant inductive coupling piecewise linear state space representation used model class rectifier including rectifying diode forward voltage drop resistance equivalent series resistance resonant inductor power quality parameters power factor total harmonic distortion calculated different loading conditions extensive experimental results based prototype presented confirm performed analysis efficient operation rectifier impressive operating efficiency achieved resonant frequency khz
objective aim study determine clinical significance slightly lateral ventricular enlargement methods examined infants gestational age weeks greater assessed presence ventricular enlargement apparent space observed frontal horn body lateral ventricle transfontanel ultrasound scan results two hundred forty eight infants ventricular enlargement atrial widths infants less ventricular enlargement correlated cesarean delivery gestational age birth weight respiratory disturbance delivery respiratory inhibition crying riac ventricular enlargement could divided three types ultrasound findings forty five infants showed enlargement anterior horn type infants showed enlargement body posterior horn type infants showed whole enlargement anterior posterior horn type infants type correlated intrauterine growth restriction placenta previa male gender birth weight infants type correlated cesarean delivery infants type correlated diabetes mellitus respiratory disturbance delivery riac feeding hypoxemia conclusions slightly lateral ventricular enlargement considered clinically significant
review highlights story methotrexate mtx drug discovered treatment childhood leukemia became mainstay treatment standard care rheumatoid arthritis also found useful several additional related rheumatological diseases several synthetic disease modifying antirheumatic drugs csdmards treating discovered serendipitously use low dose mtx mtx based sound reasoning astute observations made difference high dose mtx mtx used treatment childhood leukaemia malignancies mtx used rheumatology emphasized
study presents protection method fingerprint templates using fused structures feature level authors compute two transformed features minutiae points namely local structure distant structure structures represented bit strings fusion bit strings done feature level produce cancelable template equal error rate eer fingerprint verification competition fvc database databases eer fvc proves tenability proposed method
dynamic reduced models rms derived rigorous models highly desired speeding dynamic simulations useful software tool named builder developed automatically generate data driven rms high fidelity dynamic models allows user configure input output variables sample input space generate sequences step changes launch high fidelity model simulations fit simulation results finally visualize validate decoupled net dabnet nonlinear system identification model used main type enhanced model nonlinear multiple input multiple output dynamic systems options double pole formulation handle fast slow time scales pole value optimization builder tool successfully used generate rms highly nonlinear neutralization reactor system two time scale bubbling fluidized bed adsorber reactor capture elsevier ltd rights reserved
paper gives detailed derivation parameterized cage induction machine dynamic model natural frame reference model suitable analysis impact different number rotor bars machine transients well steady state performances initial induction machine design process predetermined number stator slots rotor bars parameterized model means different number rotor bars could chosen resulting different machine parameters process stator winding scheme well rated power machine invariant model machine derived means winding functions thus way described powerful model obtained enables analysis dozen different number rotor bars hour advantage self evident compared models based finite element method power model illustrated analysis specific machine three different numbers rotor bars
atopic diseases like asthma allergies various foodborne proteins among widespread chronic diseases newborns allergy prone skewed immune response increasing scientific reports indicate mother immune system plays crucial role mediating development fetal infant immune responses lactating mammary glands part integrated mucosal immune system confined production antibodies particularly targeted pathogenic agents mother environment later encountered newborns passive immunity mother milk critical newborn immune maturation thus understanding maternal influence childhood atopic risk newborn immune maturation could suggest novel treatment prevention strategies probiotics proposed harmonize imbalance allergic diseases however mechanism remains largely unknown feeding probiotics mothers offspring prenatal postnatal periods inhibit allergies newborns may possible preventive approach atopic diseases hence present review focuses role feeding probiotics mothers pregnancy lactation well newborns suckling post weaning periods possible modulators activation maternal infant immune response downregulate allergy prone biased newborn system
work presents tone mapping operator tmo adjusts high dynamic range hdr image sensor data limited dynamic range conventional displays analog signal processing based photographic tone reproduction ptr suitable analog circuit design cmos image sensor order reduce hardware cost operation time real time image processing reason characteristic advantage calculation limitation analog technology considered tmo algorithm proposal furthermore appropriate modelling built simulated verilog function algorithm feasible analog processing frequency analog tmo upper mhz consumes simulation results test images compared digital global tmo proposed analog tmo provides reasonable similar dynamic range compression
paper new method increase bandwidth rogowski current sensors presented instead using termination resistor proposed method simple circuit based transimpedance amplifier used suppress parasitic capacitance coil using lumped model rogowski coil bandwidth gain noise proposed current sensor analyzed analyses validated simulation measurement results measurement proposed circuit demonstrates without special coil design bandwidth close mhz achieved using simple circuit shelf electronic components elsevier rights reserved
objective study designed assess emergency contraception knowledge attitude practices among female students parakou university methods descriptive cross sectional survey conducted female students recruited cluster sampling various university departments predefined questionnaire used interview students consented participate survey data collected analysed epi info software variables compared chi square test limit significance results half students familiar emergency contraception method informed friends media already used method least following unprotected sexual intercourse age reported irregular sexual partners conclusion students familiar easy access method however repeated use method highlights need better information students concerning classical methods contraception awareness campaign conducted campus order reduce currently high rate non medical clandestine abortion
objectives chronic gneck shoulder pain cnsp common clinical symptom cervical spondylotic radiculopathy several studies using resting state functional magnetic resonance imaging fmri reported chronic pain diseases accompanied structural functional changes brain however fmri studies examined cnsp current study investigated cerebral structural functional changes cnsp patients methods total cnsp patients healthy volunteers participated study fmri images acquired voxel based morphometry analysis applied structural images regional homogeneity reho extracted fmri statistical analysis performed post processing images reho parameter maps results results revealed significant differences brain structure two groups patient group reho values significantly increased bilateral middle frontal gyrus decreased left insula superior frontal gyrus middle cingulate gyrus supplementary motor area right postcentral gyrus superior parietal lobule conclusions initial structural fmri study cnsp revealed characteristic features spontaneous brain activity cnsp patients findings may helpful increasing understanding neuropathology cnsp
unique aspects childhood exposure products need childs specific exposure data study developed probabilistic exposure model lotion transfer diapered skin normal use baby wipes children months age monte carlo simulations used baby wipe diary data germany body weight data lotion transfer data single multiple wipes adjusting separate diaper changes models predicted declining number wipes used day reduction lotion transfer age body weight increased experimental testing multiple sequential wipes used overlapping area showed reduction lotion deposition first wipe overall weighted population average approximate diapering period months across three geographies percentiles day respectively day depending whether reduction due overlap implemented statistical model represents effective strategy determine exposure baby wipes lotion exposure based risk assessment authors published elsevier inc
distributed computing strategy network wireless sensors emerged promising application order enable real time structural health monitoring previous studies distributed computing strategy consider relatively simple operations like modal parameters identification frequencies modal shapes directly assess structural health condition demanded many practical engineering applications article focuses developing distributed computing strategy techniques wireless sensor networks used direct stiffness estimation structural damage locations extent improved frequency domain regression method proposed detect quantify damage frame structures proposed method static condensation technique adopted reconstruct rotational responses joints considered inputs estimate stiffness therefore improved method provides practical accurate tool structural damage detection numerical simulation five story two bay frame structure demonstrates proposed damage detection method using limited number wireless sensors identify locate quantify structural stiffness changes accurately
introduction hypothesized implementation novel mental skills curriculum msc laparoscopic simulator training would improve mental skills performance decrease stress methods sixty volunteer novices randomized intervention control groups participants received fls training intervention group also participated msc skill transfer retention assessed live porcine model training months later respectively performance assessed using test performance strategies tops mental skills fls metrics laparoscopic performance state trait anxiety inventory stai heart rate stress results fifty five participants completed training transfer test retention test significant differences groups baseline compared controls intervention group significantly improved mental skill use demonstrated higher laparoscopic skill improvement retention reported less stress transfer test conclusions msc implemented study effectively enhanced participants mental skill use reduced cognitive stress operating room small impact laparoscopic performance elsevier inc rights reserved
korea amendment child welfare act made required national study estimating occurrence rate child abuse neglect every years present study reports major findings first national study conducted amendment aim study estimate prevalence child physical psychological maltreatment cppm korea explore basic characteristics associated incidents household surveys administered caregivers focal children school age older estimated prevalence cppm using parent child conflict tactic scale developed straus occurrence rate cppm korea instances differing household income poverty status size region children experienced physical psychological maltreatment likely witness abuse siblings domestic violence implications findings discussed recommendations made research
water pollution major concern agrarian societies like pakistan pharmaceutical industries amongst foremost contributor industrial waste present study addresses generation oxidative stress caused months exposure pharmaceutical wastewater rats response oral treatment vitamin potent antioxidant rats randomized five groups named negative control pharmaceutical wastewater pew pew pew pew vitamin oxidative damage rats evaluated estimation activities total superoxide dismutase sod catalase cat concentration hydrogen peroxide liver kidney blood plasma exposure pharmaceutical wastewater significantly decreased activities sod cat concentration liver kidney blood plasma exposure pharmaceutical wastewater exhibited maximum decline sod activity activity reduced protein plasma kidney liver respectively exposure wastewater minimized activity cat hemoglobin protein blood kidney liver respectively treatment vitamin significantly increased activity sod cat however increase concentration also observed vitamin exposed rats histopathology kidney revealed coagulative necrosis renal epithelial cells peritubular congestion endocardium showed infiltration inflammatory cells cellular breakdown areas lung sections exhibited atelectasis emphysema alveoli suggesting decline lung function anatomy liver also compromised due severe degeneration cellular swelling present study concluded pharmaceutical wastewater induced severe oxidative stress wistar rats ensued histopathological lesions several vital organs suggesting high toxicity non enzymatic antioxidant vitamin may ameliorate oxidative stress induced pharmaceutical wastewater
objective ascertain perceptions women deprived communities national tobacco control measures england methods qualitative study women smokers smokers disadvantaged areas used national health service nhs stop smoking service data collected focus group semi structured interviews subjected thematic analysis results ban smoking confined public places perceived effective measure tobacco control methods restrict accessibility including removing point sale displays raising price preventing sales certain places perceived effective techniques deter smoking initiation prevent triggering temptation smoke someone motivated quit helpful change attitudes behaviors among current smokers women felt desensitized health warnings used tobacco products public health campaigns gain framed messages likely engage smokers want quit loss framed messages participants felt focusing personal appearance children effective conclusions strategies tailored attitudes beliefs among women smokers consider gain framed messages messages focused effects appearance children promote cessation prevent relapse
types ambers naturally occurring relatively hard durable resinite polymers derived exudates trees resource coveted thousands years due numerous useful properties industrial processes beauty purported medicinal properties labdane diterpenoid based ambers represent abundant important resinites earth resinites dwindling nonrenewable natural resource new source materials needs established recent advances sequencing technologies biochemical engineering rapidly accelerating rate identifying assigning function genes involved terpenoid biosynthesis well producing industrial scale quantities desired small molecules bacteria yeast provided new tools engineering metabolic pathways capable producing diterpenoid monomers enable production custom tailored resinite like polymers furthermore biosynthetic toolbox continuously expanding providing new possibilities renewing dwindling stocks naturally occurring resinite materials engineering new materials future applications wiley periodicals inc biopolymers
large number urban infrastructure renewal activities occurring cities throughout world leads social economic environmental impacts communities vicinity coordinated effort required streamline activities paper presents framework enable temporal time based coordination water sewer road intervention activities intervention activities include routine maintenance renewal replacement physical assets coordination framework considers life cycle costs infrastructure level service risk exposure system operators model enables infrastructure asset managers trade options delaying versus bringing forward intervention activities one system order executed conjunction another located system right way framework relies combination meta heuristics goal based optimisation order demonstrate applicability framework case study major infrastructure corridor cairo egypt taken example results show framework scaled include infrastructure systems located right way like electricity gas telecom provided information shared among entities
internal users main causes anomalous suspicious behaviors communication network even traditional security middleboxes present internal attacks may lead network outages leakage sensitive information article propose broflow intrusion detection prevention system based bro traffic analyzer global network view software defined networks sdn provided openflow broflow main contributions dynamic elastic resource provision traffic analyzing machines demand real time detection dos attacks simple algorithms implemented policy language network events iii immediate reaction dos attacks dropping malicious flows close sources near optimal placement sensors proposed heuristic strategically positioning sensors network infrastructure shared multi tenants minimum number sensors developed prototype proposed system evaluated virtual environment future internet testbed security fits evaluation system attack shows broflow guarantees forwarding legitimate packets maximal link rate reducing maximal network delay caused attack broflow reaches bandwidth gain compared conventional firewalls approaches even attackers legitimate tenants acting collusion addition system reduces sensors number keeping full coverage network flows
background repeat abortion public health concern favored many obstetric social factors purpose study identify associated factors repeated abortion region monastir tunisia common mental disorders cmd anxiety depression also evaluated women seeking voluntary repeated abortion methods carried cross sectional study january april reproductive health center rhc region monastir tunisia study part prospective design mental disorders intimate partner violence among women seeking abortions rhc among women referred rhc selected seeking voluntary abortion medical surgical method data women demographic characters knowledge practices contraceptive methods abortion collected abortion day via structured questionnaire data anxiety depression status evaluated post abortal control visit weeks following pregnancy termination results interviewed women seeking repeated abortions multivariate analysis showed increased age lower level women school education single status poor knowledge birth control methods history conflict abuse male partner uniquely associated undergoing repeat compared initial abortion cmd significantly higher women undergoing second subsequent abortion single lower educated women women relating history conflicts abuse report cmd others conclusion health facilities providing abortion services need pay attention women seeking repeat abortion studies needed well establish relation number abortion occurrence severity cmd
generalizability psychopathy construct eastern european cultures well studied prior studies evaluated psychopathy non offender samples population current validation study examines factor structure internal consistency external validity bulgarian translation hare psychopathy checklist screening version two hundred sixty two bulgarian adults general community assessed history substance dependence confirmatory factor analysis indicated good fit two three four factor models psychopathy zero order partial correlation analyses conducted two factors psychopathy criterion measures antisocial behavior internalizing externalizing psychopathology personality traits addictive disorders demographic characteristics relationships external variables provided evidence convergent discriminant validity psychopathy construct bulgarian community sample
taking human resource development primary context article asks scholars mobilise queer theory concepts move beyond treating lesbian gay bisexual transgender identities binaried bounded stable categories human resource development scholarship made important albeit limited progress article provides review queer theory help scholars engage deeply key concepts theoretical resources end particular one article main contributions advancing nascent roads judith butler writing made human resource development management education learning linking theory gender performativity notion cultural intelligibility aim article show lesbian gay bisexual transgender identity categories destabilised examined queerly performatively constituted permanently open contestation resignification crucially wider applications implications queer theory drawn queer pedagogy inform management education article also highlights possibilities management learning scholars queer identities heterosexual organisations modes organising
paper deals mathematical modelling impulse waveforms impulse switching functions used electrical engineering using transformation impulse switching functions obtained discrete time instant impulse sequences exciting functions applying impulse sequence electrical circuit response state variables investigated using inverse transformation theoretical derived wave forms verified spice circuit simulator compared simulation worked results
process scheduling algorithm created help circular linked list skip ring data structures algorithms skip ring data structure consists circular link lists formed layers linked canonical way time complexity search insertion deletion equals lgn element skip ring data structure therefore skip ring data structure employed effectively lgn circumstances circular linked lists used paper applications data structures red black tree binary search tree skip ring performed obtained results compared obtained results demonstrated skip ring data structure superior red black tree binary search tree process scheduling important part operating systems linux operating system version uses completely fair scheduler process scheduling using red black tree data structures whereas skip ring data structure used effectively instead red black tree data structure new algorithm process scheduling called fair priority scheduling proposed paper
alzheimer disease multifactoial disorder caused interaction genetic epigenetic environmental factors formation cytotoxic oligomers consisting beta peptide widely accepted one main key events triggering development alzheimer disease beta peptide production results specific proteolytic processing amyloid precursor protein app deciphering factors governing activity secretases responsible cleavage app still critical issue kits available commercially measure enzymatic activity secretases cells lysates vitro contrast developed prototypal rapid bioassay provides visible information proteolytic processing app directly living cells app fused monomeric variant green fluorescent protein monomeric variant red fluorescent protein terminal terminal mchappmgfp respectively changes proteolytic processing rate transfected human neuroblastoma rat neuronal cells imaged confocal microscopy changes red green fluorescence intensity ratio significant decrease mean red green ratio observed cells expressing beta secretase bace alpha secretase adam fused monomeric blue fluorescent protein confirms proteolytic site still accessible specific sirna used evaluate contribution endogenous bace interestingly found degree proteolytic processing app completely homogeneous within single cell high degree variability cells type also able follow fluorescence spectrometer changes red emission intensity extracellular medium bace overexpressed represents complementary approach fluorescence microscopy rapidly detecting changes proteolytic processing app real time order allow discrimination alpha beta secretase activity created variant mchappmgfp mutation inhibits alpha secretase cleavage without perturbing beta secretase processing moreover obtained quantitatively robust estimate changes red green ratio conditions using flow cytometer able simultaneously excite measure red green fluorescence novel approach lay foundation bioassay suitable study effect drugs particular conditions investigate unbiased way proteolytic processing app single living cells order elucidate causes variability factors driving processing app
current study investigated use various information communication technologies related social capital parenting efficacy among parents youth specifically using structural equation modeling examined direct indirect associations ict use social capital parenting efficacy using data parents youth parents ict use directly associated social capital direction association differed ict parenting efficacy positively associated parents social capital also parents ict use directly indirectly associated parenting efficacy parents using email checking news events online frequently likely report higher parenting efficacy use blogs negatively associated parenting efficacy results suggest parent family life educators optimize education programs utilizing different ici based purpose program elsevier ltd rights reserved
gesture recognition gesture easy influenced nonlinear factors illumination wrists motion blur etc based analysis svm classification method effect practical application paper proposes gesture method based combination nonlinear support vector machine svm linear discriminant analysis lda svm lda first works gesture recognition system constituted multiple surface electrode sensor microcontroller acquisition unit computer second get best classification feature image linear discriminant analysis lda feature extraction finally carry classification recognition gesture characteristic vector applying nearest neighbor classifier time compared classification algorithms get advantages disadvantages algorithm paper experimental results show svm lda gain higher recognition rate provide theoretical data support researcher electromyogram artificial hands control choose appropriate means recognition
recent research demonstrates although risk disease disability clearly increases age poor health need inevitable consequence aging healthy lifestyle influential genetic factors assisting older adults avoid decline deterioration traditionally associated aging many effective strategies reducing disease disability widely underused escalante health partnerships community based nurse managed health promotion chronic disease care management program community residing older adults program base supports multidisciplinary collaborative practice model responded health needs members community high risk developing chronic conditions preliminary comparisons health status program participants national norms demonstrate seniors report better general health performance roles social functioning strongest correlations occurring general health vitality general health role physical addition participants doctor visits per year comparison office visits national comparison group hospital days per year comparison hospital days referenced population collaborative partnership model replicated cost effectively communities
aim present study understand risk injury relation fitness retrospective occupational cohort firefighters tucson arizona annual medical evaluations injury surveillance data linked compare levels aerobic fitness injured employees noninjured employees individual outcomes evaluated included injuries exercise related injuries sprains strains time event analyses conducted determine association levels fitness injury likelihood fitness defined relative aerobic capacity max associated injury risk persons lowest fitness level category max minute times likely confidence interval sustain injury highest fitness level category max minute max minute times confidence interval likely incur injury hazard ratios found greater sprains strains results suggest improving relative aerobic capacity metabolic equivalent task approximately minute reduces risk injury findings illustrate importance fitness reducing risk injury physically demanding occupations fire service support need provide dedicated resources structured fitness programming promotion injury prevention strategies people fields
background role adjuvant chemotherapy within urothelial carcinoma urinary bladder ucub patients radical cystectomy debate assessed contemporary utilization rates also examined rates according patient disease sociodemographic characteristics methods relied seer medicare database non organ confined muscle invasive ucub patients underwent without neoadjuvant chemotherapy delivery multivariable logistic regression analyses tested predictors use stage stage year diagnosis age gender race radiotherapy administration marital urban socioeconomic status tumor grade charlson comorbidity index cci results overall patients identified received rate time multivariable analyses stages ptn odds ratio year diagnosis married status advanced age independent predictors neither race cci demonstrated significance conclusions conclusion report lower anticipated overall use nonetheless rate increased presence lymph node invasion regardless stage important variable increased use older unmarried individuals less likely receive rates higher ucub patients individuals
study vitro device mimics oral phase swallowing calibrated using vivo measurements oral flow behavior different newtonian non newtonian solutions investigated vitro revealing shear thinning thickeners used treatment dysphagia behave similar low viscosity newtonian liquids active swallowing provide better control bolus swallow initiated theoretical model used interpret experimental results enables identification two dynamical regimes flow bolus first inertial regime constant acceleration dependent applied force system inertia possibly followed viscous regime viscosity governs constant velocity bolus mechanistic understanding provides plausible explanation similarities differences swallowing performance shear thinning newtonian liquids finally physiological implications model experimental results discussed vitro theoretical results suggest individuals poor tongue strength sensitive overly thickened boluses model also suggests effects system inertia significant density bolus plays negligible role dynamics confirmed experiments high density contrast agent used videofluoroscopy revealing theologically matched contrast agents thickener solutions flow similarly vitro experiments theoretical insights help designing novel thickener formulations clinical evaluations elsevier ltd rights reserved
turf toe common injury variety different athletes especially involved contact sports played rigid surfaces caused hyperextension injury hallux metatarsophalangeal joint resulting attenuation tearing plantar capsular ligamentous complex treatment generally consists nonoperative measures rest ice nonsteroidal anti inflammatory drugs taping stiff sole shoe walking boot casting recent increase use biologics platelet rich plasma autologous conditioned plasma treatment variety orthopaedic conditions study reports cases turf toe treated combination toradol autologous conditioned plasma case presentations followed literature review use biologics treatment sports injuries elsevier inc rights reserved
present portable platform called pic engine accelerating particle cell pic codes heterogeneous many core architectures graphic processing units gpus aim development efficient simulations future exascale systems allowing different parallelization strategies depending application problem specific architecture end platform contains basic steps pic algorithm designed test bed different algorithmic options data structures among architectures engine explore particular attention given systems equipped gpus study demonstrates portable pic implementation based openacc programming model achieve performance closely matching theoretical predictions using cray system piz daint swiss national supercomputing centre cscs show pic engine running nvidia kepler gpu outperform one intel sandy bridge core cpu factor published elsevier
international software benchmarking standards group isbsg maintains repository data completed software projects common use isbsg dataset investigate models estimate software project size effort duration cost aim paper determine extent variables isbsg dataset used software engineering build effort estimation models purpose systematic mapping study applied research papers obtained filtering process published end listed independent variables used effort estimation models usage isbsg variables filtering dependent variables independent variables described variables mostly used independent variables effort estimation identified analysed detail reference papers types estimation methods used propose guidelines help researchers make informed decisions isbsg variables select effort estimation models elsevier inc rights reserved
programming specific sites stack overflow used extensively software developers knowledge sharing acquisition due cross reference questions answers note users also reference urls external site paper url sharing refers internal urls within site unless otherwise stated knowledge diffused site forming large knowledge network stack overflow developers share urls community feedback knowledge shared unique topological semantic properties resulting knowledge network stack overflow knowledge network become stable reach stability answering questions help software engineering community better understand knowledge diffusion process programming specific sites like stack overflow thereby enabling effective knowledge sharing knowledge use knowledge representation search community previous work focused analyzing user activities sites mining textual content sites article present methodology analyze url sharing activities stack overflow use open coding method analyze users share urls stack overflow develop set quantitative analysis methods study structural dynamic properties emergent knowledge network stack overflow also identify system designs community norms social behavior theories help explain empirical findings study obtain depth understanding knowledge diffusion process stack overflow expose implications url sharing behavior site design developers use crowdsourced knowledge stack overflow future research knowledge representation search
main focus safety design structures vibration serviceability often overlooked mismanaged resulting high profile structures failing publicly perform adequately human dynamic loading due walking running jumping standard tool inform better design prove fitness purpose entering service design retrofits modal testing procedure typically involves acceleration measurements using array wired sensors force generation using mechanical shaker critical often overlooked aspect using input force output response relationships enable estimation modal mass key parameter directly controlling vibration levels service paper describes use wireless inertial measurement units imus designed biomechanics motion capture applications modal testing footbridge imus first used output vibration survey identify mode frequencies shapes damping ratios simultaneous measurement body accelerations human subject jumping excite specific vibrations modes build bridge deck accelerations jumping location using mode shapes vertical acceleration data suitable body landmark scaled body mass thus providing jumping force data possible create frequency response functions estimate modal masses modal mass estimates bridge checked estimates obtained using instrumented hammer known mass distributions showing consistency among experimental estimates finally method used applied research application short span footbridge benefits logistical operational simplicity afforded highly portable easy use imus proved extremely useful efficient evaluation vibration serviceability including estimation modal masses authors published elsevier ltd
investigation paper extended korteweg vries equation via bell polynomial approach symbolic computation equation transformed two kinds bilinear equations choosing different coefficients namely kdv type equation kdv lax type equation one hand soliton solutions bilinear backlund transformation lax pair darboux covariant lax pair infinite conservation laws kdv lax type equation constructed hand basis hirota bilinear method riemann theta function quasiperiodic wave solution kdv type equation also presented exact relation one periodic wave solution one soliton solution established rigorously shown one periodic wave solution tend one soliton solution small amplitude limit copyright john wiley sons ltd
objective compare screening performance psoriasis epidemiology screening tool pest psoriatic arthritis screening evaluation pase early arthritis psoriatic patients earp questionnaires detecting psa among psoriasis patients primary care setting methods cross sectional study primary care psoriasis patients risk psa completed pest pase earp questionnaires clinically evaluated trained research nurse psa case defined rheumatologist according caspar criteria sensitivity specificity determined pest earp cut offs pase cut offs results psa diagnosed patients pest sensitivity specificity pase validated two different cut offs cut led sensitivity specificity whereas lower cut led sensitivity specificity earp found sensitivity specificity conclusion pest questionnaire favourable trade sensitivity specificity screen psa however prevalence psoriasis psa fairly low primary care screening psoriasis patients musculoskeletal complaints may better allocation resources
army corps engineers hydrologic engineering center river analysis system hec ras widely used software application performing one dimensional two dimensional steady unsteady flow river hydraulics calculations sediment transport mobile bed modeling water quality analysis user hec ras often unique applications including coupling software perform system analysis optimization flooding structures multi objective reservoir operation uncertainty one state art environment integrating software matlab integrates computation visualization programming easy use environment paper presents set matlab scripts write input files read output files make plots execute parallel computations perform fully automated functions hec ras examples procedures presented throughout paper illustrated using river reservoir network involves ten inline structures dams operation gates dams elsevier ltd rights reserved
since early research evidence accumulating suggests exposure violence television movies video games cell phones internet increases risk violent behavior viewer part growing environment filled real violence increases risk behaving violently current review research evidence critically assessed psychological theory explains exposure violence detrimental effects short long term elaborated finally size media violence effect compared well known threats society estimate important threat considered society adolescent medicine rights reserved
natural lung aging marked molecular changes occur development maturation late life decline cellular whole organ level degenerative changes hallmark natural aging shorter telomeres increased expression cellular senescence markers increased dna damage oxidative stress apoptosis accompanied diminished elasticity reach pathological levels aging humans form chronic respiratory disease aging strongly correlates development incidence chronic respiratory diseases including cancer idiopathic pulmonary fibrosis strongly linked development chronic obstructive pulmonary disease lung failure due aging traced loss lung stem cell regenerative capacity within distinctive stem cell niches found within compartment lung current knowledge identity function stem cell compartments largely drawn variety transgenic spontaneously mutated mouse models characterized rapid rates aging used examine regeneration injury context natural accelerated aging much work focused failure epithelial cell populations key component aging process additional studies shown aging global phenomenon lung also impacts resident endothelial mesenchymal immune cell populations review examine aging process dependent specific changes molecular pathways within multiple lung cell populations karger basel
propose architecture reduces power consumption active area modulator reduction number active components simplification topology proposed architecture reduces power consumption active area reducing number active components simplifying modulator topology novel second order loop filter uses single operational amplifier resonator reduces number active elements enhances controllability transfer function trapezoidal shape half delayed return zero feedback dac eliminates loop delay compensation circuitry improves pulse delay sensitivity simple features modulator allow higher frequency operation design flexibility implemented cmos technology prototype modulator occupies active area consumes power supply achieves dynamic range peak sndr mhz signal bandwidth sampling frequency mhz figure merit modulator conversion step
psychotic disorders severe psychiatric conditions patients difficulties identifying facial expressions appear highly sensitive presence emotional distractors yet study investigated whether perceptual load modulates interference emotional distractors goal test whether psychotic patients sensitive irrelevant emotional stimulus even task demands high amount attentional resources twenty two participants schizophrenia schizoaffective disorder twenty two healthy controls performed target letter discrimination task emotional task irrelevant stimulus angry happy neutral facial expressions target letters presented among distrator letters could similar low perceptual load different high load participants discriminate target letter ignore facial expression results showed patients prone distraction task irrelevant stimulus especially high load suggesting difficulties attention control moreover psychotic patients happy faces caused higher interference task whereas neutral angry faces resulted less interference findings could provide innovative approaches regarding attentional deficits social contexts patients schizophrenia spectrum disorders
negatively charged events often remembered high accuracy less prone memory distortions however whether applies individuals high emotional involvement well understood explore issue present study investigated whether internalizing depressive anxious trait affected occurrence inferential memory errors emotional neutral events recognition memory paradigm consisting pictorial scripted material presented two groups young adults one high scores depression anxiety scales one control group results showed increased proportion causal false memories inferring seen cause viewed effect depressive anxious group encoded events negative neutral important false memories occurred characterized recollective experience conversely control participants negative material found protect memory distortions compared neutral material results discussed light previous research memory distortions individuals emotional disturbances highlight possibilities offered using new paradigm studying false memories elsevier ltd rights reserved
purpose purpose paper investigate halbach array effects surface mounted permanent magnet machine smpm terms self sensing torque capabilities comparison conventional smpm radially magnetized rotor halbach machine carried design methodology approach geometric parameters two machines optimized using genetic algorithm looking pareto performance machines geometry calculated finite element analysis fea software two parametric machine models realized matlab coupled fea toolboxes outer volume machine thus copper loss per volume kept constant pareto front approach simultaneously considers looks two aims used provide trade torque sensorless performances findings two machines results compared separately loading condition according results superiority halbach machine shown terms sensorless capability compromising torque performance additionally paper shows self sensing properties smpm machine considered design stage machine originality value halbach machine design optimization presented using pareto optimal set provides trade comparison two aims without using weightings sensorless performance torque capability work sensorless capability halbach type smpm literature
background suggested dementia caused neuronal damage due chronic inflammation peripheral sources oral cavity periodontal disease objective aim review assess risk dementia cognitive impairment associated chronic periodontitis multiple tooth loss materials methods extensive search electronic databases articles relation periodontitis tooth loss dementia published april conducted experimental human studies provided description consistent multiple tooth loss chronic periodontal disease cognitive impairment obtained validated methods selected data extracted articles included study design country origin sample size methods used assess periodontitis cognition average age baseline number years follow newcastle ottawa scale used assess quality human studies results literature search yielded articles independently screened articles included review four human studies reported association subsequent dementia multiple tooth loss one human study reported chronic periodontal disease associated dementia eight experimental studies demonstrated association cognitive impairment tooth loss conclusion literature chronic periodontitis multiple tooth loss risk factors dementia remains inconclusive randomised clinical trials association periodontitis dementia uniform criteria evaluation diagnosis periodontitis warranted
paper presents high performance computing hpc framework monte carlo simulations ocean color application domain objective optimize parallel radiative transfer code named mox developed authors create virtual marine environment investigating quality data products derived situ measurements water radiometric quantities consolidated set solutions performance modeling prediction optimization implemented enhance efficiency simulations hpc run time infrastructures hpc machine learning adaptive computing techniques applied taking account clear separation systematic treatment accuracy precision requirements large scale simulations added value work integration computational methods tools simulations form hpc oriented problem solving environment specifically tailored investigate data acquisition reduction methods field measurements study results highlight benefit close collaboration hpc application domain researchers improve efficiency flexibility computer simulations marine optics application domain authors concurrency computation practice experience published john wiley sons ltd
cell activating factor tnf family critical survival maturation cells play role pathophysiology chronic rhinosinusitis nasal polyps crswnp study nasal tissues enrolled crswnp patients asthmatic non asthmatic crssnp patients ten control subjects respectively immunoreactivity baff examined using immunohistochemistry staining mrna expression baff eglt aid gata crth examined using real time rtpcr protein levels baff ige measured using elisa assays unicap system respectively found numbers baff cells cells cells cells plasma cells significantly increased polyp tissues compared control groups concentrations baff ige tissue homogenates also significantly increased polyp tissues compared control groups baff protein level polyp homogenates significantly associated ige levels concomitant asthma crswnp patients findings indicate baff expression significantly increased crswnp patients may orchestrate inflammatory load polyp tissues regulating cell mediated response
paper proposes gravity heat pipe exchanger used cooling communication base station replace traditional air conditioning system winter transition seasons tests conducted commercial available gravity heat pipe exchanger experiment performed study effects air flow rate temperature cooling capacity heat transfer unit number ntu cooling efficiency heat pipe exchanger results showed larger air flow rate smaller ntu larger cooling capacity based analysis experimental data proved gravity heat pipe exchanger could reduce running time operating cost air conditioning system according practical applications yearly cooling loads typical communication base station calculated five typical cities represent five climatic zones china results validated energy saving using gravity heat pipe exchanger significant highest annual electricity saving rate achieved kunming lowest annual electricity saving rate obtained guangzhou among five climatic zones fitted correlation cooling capacity term outdoor temperature generic evaluate approximately performance applying gravity heat pipe exchanger actual applications subject various outdoor temperatures elsevier ltd rights reserved
imbalances excitation inhibition synaptic transmission neural circuits implicated autism spectrum disorders excitation inhibition imbalances frequently observed animal models autism spectrum disorders correction normalizes key autistic like phenotypes animals results suggest excitation inhibition imbalances may contribute development maintenance autism spectrum disorders represent important therapeutic target
years domestic induction hobs becoming increasingly popular due specific features safety cleanliness quick warming high efficiency features derive fact heating directly generated vessel unlike traditional contact heating methods specially later feature attracting attention researchers devoted highly efficient power electronic systems extensive upsurge electricity lack availability future society forces think another alternative solar energy provides cost effective solution energy problems paper presents adept cooking system using solar energy cook faster easier cheaper compared cooking system paper presents simulation perturbation observation mppt technique extract maximum energy photovoltaic systems controller get accurate smooth power control resonant converter main desired features designing inverter domestic induction heating smooth output power control efficiency high efficiency voltage control induction cooktop prototype designed operating switching frequency khz frequency line rms voltage line frequency output pulse width modulation pwm technique used providing pulses mosfet via dspic microcontroller hardware implementation dspicfand mosfet irf used along tlp driver circuit particular features smooth voltage control reduction conduction loss high efficiency matlab simulation mppt control solar controller resonant converter presented
background diagnosis sports related concussion often dependent athlete self reporting symptoms suggested improving youth athlete knowledge attitudes toward concussion may increase self reporting behaviour objective study determine novel concussion educational program improves knowledge attitudes concussion among cohort elite male bantam midget aaa hockey players methods fifty seven male bantam midget aaa level hockey players mean age years recruited local community participant completed modified version rosenbaum concussion knowledge attitudes survey student version immediately concussion educational presentation follow sessions arranged months presentation assessed retention knowledge attitude changes results forty three players completed three surveys concussion knowledge attitude scores significantly increased pre post presentation respectively long term follow knowledge levels remained significantly higher baseline mean attitude scores also increased follow however increase statistically significant conclusions concussion educational program led immediate improvement concussion knowledge attitudes among elite male bantam midget aaa hockey players increased knowledge maintained long term follow improved attitude future studies investigate whether similar educational programs influence symptom reporting concussion incidence addition focus maintain improved concussion attitudes
aim paper determine effect soil structure interaction time dependent material properties behavior concrete box girder highway bridges two different finite element analyses one stage construction stage carried komurhan bridge elazig malatya province turkey firat river one stage analysis assume structure built second material properties structure change different loads site conditions time however construction stage analysis considers construction time time dependent material properties main side spans bridge respectively bridge constructed years balanced cantilever construction method parameters soil structure interaction ssi time dependent material properties construction method taken consideration construction stage analysis ssi single parameter taking consideration one stage analysis finite element model bridge created commercial program sap time dependent material properties elasticity modulus creep shrinkage concrete relaxation steel soft medium firm soils selected evaluating ssi analyses results two different finite element analyses compared seen construction stage ssi remarkable effect structural behavior bridge
whenever social science research directly relates people everyday rationalities social scientific findings collide laypersons subjective experiences research may become instrumentalized media political authorities misconstrued general public scientific programs findings likely misperceived devalued threaten fundamental moral convictions justice equality nonviolence threaten people needs positive social identity article exemplify cognitive emotional processes involved misperceptions context media violence research research potentially harmful effect playing violent video games implications consequences analysis communication science public discussed
overactive bladder affects significant portion overall population substantial impact daily activities quality life considering treatment behavioral therapies instituted first followed medical therapies anticholinergic medications beta agonists often used initial pharmacologic therapy caution taken prescribing anticholinergic medications frail cognitively impaired patients recently concerns developed regarding anticholinergic medications associated risk cognitive impairment dementia alzheimer disease general population given available evidence shown significant associations anticholinergic medication use increased risk cognitive impairment dementia providers counsel associated risks prescribe lowest effective dose consider alternative medications patients risk
earthquake affected areas speed reliability assessing damage suffered strategic structures long span bridges paramount importance civil protection operations organization coordination immediate remedial measures structure safety paper present results obtained applying damage identification method termed interpolation damage detection method numerical model shimotsui seto bridge suspension bridge long span steel truss deck method allows detect localized reductions stiffness along bridge deck base accelerometric responses recorded main girder damaging seismic event aftershock following onset damage possible long responses recorded locations undamaged structure available response suspension bridge subject seismic excitation calculated sys framework using finite element model derived original design data order reproduce real life conditions numerical results terms temporal responses artificially modified including background noise characteristic classes micro electro mechanical systems type sensors reliability interpolation damage detection method numerically verified simulating damage reduction stiffness one elements deck several different locations damage considered order study influence damage location results provided structural health monitoring methodology
culture universal phenomenon interest culture pregnancy focused medical care neglecting psychological aspects normative development purpose article examine normative gestational experiences using framework broaden build model culture positive pregnancy youth development review involved studies books book chapters obtained electronic databases focusing parental attitudes available care parental expectations cultural values nutrition likely affect unborn several protective factors emerged positive expectations early prenatal care protective cultural values appropriate nutrition sensitive health care providers interdependent supportive relationships absence protective factors predicted prenatal perinatal postnatal complications likely affect health mental health youth review findings congruent theoretical propositions positive feelings expectations broaden prenatal care adequate nutrition avoidance substance use turn positive activities help build social support interdependent relationships promote maternal infant health context protective cultural norms
burns caused hot drinks soups debilitating costly especially pediatric geriatric patients research aimed better understanding fluid properties influence severity skin burns use standard model combines heat transfer biomedical equations predict burn severity particular experimental data physical model serves input numerical model determine severity scald burns consequence actual fluid flows technique enables numerically predict heat transfer hot soup skin without need numerically estimate complex fluid mechanics thermodynamics potentially highly viscous heterogeneous soup temperature soup obviously important fact determining degree burn also find viscous fluids result severe burns slower flowing thicker fluids remain contact skin longer furthermore factors also increase severity burn higher initial fluid temperature greater fluid thermal conductivity higher thermal capacity fluid combined experimental numerical investigation finds average skin properties viscous fluid degrees fluid must contact skin around cause second degree burns cause third degree burn elsevier ltd isbi rights reserved
despite good reason believe children foster care disproportionately exposed adverse childhood experiences aces relatively little research considers exposure aces among group vulnerable children article use data national survey children health nsch nationally representative sample non institutionalized children ages united states estimate association foster care placement exposure array aces adjusted logistic regression models find children placed foster care adopted foster care compared counterparts likely experience parental divorce separation parental death parental incarceration parental abuse violence exposure household member mental illness household member substance abuse children also likely experience aces children across different thresholds socioeconomic disadvantage children households incomes poverty line across different family structures children single mother families results advance understanding children foster care already vulnerable population disproportionately exposed aces exposure given link aces health may implications children health wellbeing throughout life course elsevier ltd rights reserved
ethnopharmacological relevance liang soft capsule traditional chinese medicine treating migraines made two chinese herbs including ligusticum striatum root angelica dahurica hoffin benth hook franch sav root aim study present study aimed elucidate pharmacodynamic action mechanism animal model migraines induced glyceryl trinitrate gtn materials methods sixty rats randomly divided six groups including normal control group model control group positive group sumatriptan three groups rats intragastrically treated corresponding treatment consecutive days subcutaneously injected gtn min last treatment except normal control group model establishment behaviors rats including head scratching cage climbing development red ears observed continuously digital camera every min four hours gtn treatment rats anaesthetized blood tissue samples collected plasma calcitonin gene related peptide cgrp endothelin levels measured using radioimmunoassay method serum determined colorimetric method afterwards brainstem tissues dissected washed physiological saline divided evenly two parts one part used test monoamine levels including levels hydroxytuptamine norepinephrine dopamine fluorometric method part used determine nuclear factor kappab kappa nuclear fos inducible nitric oxide synthase inos interleukin beta beta cyclooxygenase cox levels western blot analysis results pharmacodynamic action assay greatly improved abnormal behaviors migraine rats including head scratching cage climbing development red ears mechanism assay compared control group plasma cgrp serum levels brainstem levels administration groups significantly decreased plasma levels remarkably increased moreover regulation kappa fos pro inflammatory cytokines including inos beta cox brainstem administration groups observed western blot analysis conclusions results suggested therapeutic effect migraines mechanism may related adjusting level neurotransmitters vasoactive substances consequently relieving neurogenic inflammation
objective episodic cluster headache characterized abnormalities tyrosine metabolism elevated levels dopamine tyramine octopamine synephrine low levels noradrenalin plasma platelets unknown however biochemical anomalies present constitute predisposing factor chronic cluster headache test hypothesis measured levels dopamine noradrenaline together elusive amines tyramine octopamine synephrine plasma chronic cluster patients control individuals methods plasma levels dopamine noradrenaline trace amines including tyramine octopamine synephrine measured group chronic cluster headache patients chronic cluster initio transformed episodic cluster control participants results plasma levels dopamine noradrenaline tyramine several times higher chronic cluster headache patients compared controls levels octopamine synephrine significantly lower plasma patients respect control individuals conclusions results suggest anomalies tyrosine metabolism play role pathogenesis chronic cluster headache constitute predisposing factor transformation episodic chronic form primary headache
comparison ionic electromechanically active polymers ionic eap carbon polymer composite cpc actuators considered especially attractive due possibility producing completely metal free devices however mechanical response ionic eap addition voltage frequency dependent environmental variables humidity temperature therefore similarly eaps one major challenges lies achieving controlled actuation cpc sample due size added complexity external feedback devices laser displacement sensors video cameras tend inhibit application micro scale actuators hence self sensing eap actuators capable simultaneous actuation sensing often desired thin polyvinylidene fluoride hexafluoropropylene film ionic liquid emimbf prepared masked coincidently opposite surfaces prior spray painting carbide derived carbon electrodes purpose masking create different electrically insulated electrodes surface polymer order achieve separate sections actuator sensor one piece cpc material solution electrode paint consisting carbide derived carbon emimbf dimethylacetamide applied polymer film removing masking tape completely metal free cpc actuator sophisticated electrode geometry achieved foster simultaneous sensing actuation self sensing carbon polymer actuator created
natural ventilation essential building technology long time significant role development architecture design natural ventilation replaced development air conditioning technology time however energy crisis greenhouse effect buildings inclined potential natural ventilation research use natural ventilation green building design divided three parts respectively additional structural measures space design double skin facade
paper proposes induction motor drive control method uses minimal number sensors providing link current feedback signal improved link current sampling scheme modified asymmetrical switching pattern cancel characteristic waveform errors exist three reconstructed motor line currents motor line current harmonic content reduced acceptable level eliminating torque speed oscillations inherent conventional single sensor drives consequently use single current sensor line current reconstruction technique longer acceptable low medium performance drives also drives obtaining highly accurate stable fast response priority proposed control algorithm validated using induction motor drive hardware prototype based tmsf digital signal processor
gut barrier plays crucial role spatially compartmentalizing bacteria lumen production secreted mucus fortified production secretory iga siga antimicrobial peptides proteins exception siga expression protective barrier factors largely controlled innate immune recognition microbial molecular ligands several specialized adaptations checkpoints operating mucosa scale immune response according threat prevent overreaction trillions symbionts inhabiting human intestine healthy microbiota plays key role influencing epithelial barrier functions production short chain fatty acids scfas interactions innate pattern recognition receptors mucosa driving steady state expression mucus antimicrobial factors however perturbation gut barrier homeostasis lead increased inflammatory signaling increased epithelial permeability dysbiosis microbiota recognized play role pathophysiology variety gastrointestinal disorders additionally gut brain signaling may affected prolonged mucosal immune activation leading increased afferent sensory signaling abdominal symptoms turn neuronal mechanisms affect intestinal barrier partly activation hypothalamus pituitary adrenal axis mast cell dependent mast cell independent mechanisms modulation gut barrier function nutritional interventions including strategies manipulate microbiota considered relevant target novel therapeutic preventive treatments range diseases several biomarkers used measure gut permeability loss barrier integrity intestinal diseases remains need explore use assessing effect nutritional factors gut barrier function future studies aim establish normal ranges available biomarkers predictive value gut health human cohorts
blockchains represent novel application cryptography information technology age old problems financial record keeping may lead farreaching changes corporate governance many major players financial industry began invest new technology stock exchanges proposed using blockchains new method trading corporate equities tracking ownership essay evaluates potential implications changes managers institutional investors small shareholders auditors parties involved corporate governance lower cost greater liquidity accurate record keeping transparency ownership offered blockchains may significantly upend balance power among cohorts
study extends boundary conditions mediated contact theory differentiating mediated contact quantity quality examining whether mediated contact exerts effects beyond direct contact offering causal generalizable evidence effects exposure numerous individual outgroup members news media match individual level data representative panel survey data amount coverage members two outgroups results validated sentiment analysis mediated contact especially quantity improved outgroup attitudes independently direct contact findings emerged outgroups across two outcome measures
study would like highlight advantages disadvantages distance form education ways improve learning expanding rapid rate quantitative terms qualitative parameters kazakhstan require detailed analysis weighing objective merits problem areas try justify existing requirements opportunities tools propose ways improve order higher education institutions kazakhstan including almaty management university could compete educational market world educational space aim study improve instruments creation educational products distance education includes evaluation advantages disadvantages distance learning format university model existing distance education naugramma determination weak points implementation one way contact problems causes blank shot transfer knowledge computer monitors face face contact verbal nonverbal communication teacher student conditions development recent achievements technologies teaching media communications rapid development widespread use variety technical means primarily refer computer information technology satellite communication systems educational television mass connection information systems distribution learning software videos implement model distance education three stages analyzed methods used secondary education example analyzed teaching chemistry secondary school disabled children moscow research first stage secondary school analysis applying distance form education second stage university together assessment problematic areas resulted creating effective model implemented model work great efficiency help eliminate many difficulties slow realization whole package instruments distance education
existing mountain permafrost distribution models generally offer good overview potential extent phenomenon regional scale however always able reproduce high spatial discontinuity permafrost micro scale scale specific landform ten several hundreds meters overcome lack tested alternative modelling approach using three classification algorithms belonging statistics machine learning logistic regression support vector machines random forests supervised learning techniques infer classification function labelled training data pixels permafrost absence presence aim predicting permafrost occurrence unknown research carried area western swiss alps permafrost evidences mapped ortho image interpretation rock glacier inventorying field data mainly geoelectrical thermal data relationship selected permafrost evidences permafrost controlling factors computed mentioned techniques classification performances assessed auroc range logistic regression support vector machines random forests adopted machine learning algorithms demonstrated efficient permafrost distribution modelling thanks consistent results compared field reality high resolution input dataset allows elaborating maps micro scale modelled permafrost spatial distribution less optimistic classic spatial models moreover probability output adopted algorithms offers precise overview potential distribution mountain permafrost proposing simple indexes permafrost favorability encouraging results also open way new possibilities permafrost data analysis mapping elsevier rights reserved
objective investigate ethnic differences osteoporosis body composition relationship maonan mulam hmong yao minorities china design total maonan mulam hmong yao women included cross sectional study demographic health history lifestyle information collected using questionnaires measured bioelectrical impedance analysis bone mineral density bmd assessed via calcaneal quantitative ultrasound results compared premenopausal women postmenopausal women exhibited lower fat free mass ffm muscle mass limb muscle mass score higher waist hip ratio prevalence minority adjustment age hmong women displayed highest body mass index fat mass percentage body fat visceral fat subcutaneous fat contents yao women presented highest scores lowest prevalence among four minorities greater number children older age significant risk factors ethnic groups addition results revealed ffm exhibited exactly weak positive relationship score adjusting menopausal status age participants furthermore significant ethnic differences relationship score existed four minorities studied conclusions prevalence varied menopausal status ethnic group ethnic specific relationships bmd present four minorities research needed investigate ethnic differences risk factors lower bmd develop targeted prevention strategies reduce burden across different ethnic groups china
achievement objectives precision agriculture requires development new technologies also availability portable tools used field paper describes creation novel application mobile devices called pcaps portable classification application plants soil integrates several computer vision techniques plant segmentation analysis crop pictures tool allows monitoring agricultural crops real time providing information used automate optimize calculation water needs three main modules pcaps capture cropping image analysis historical record first robust algorithm detect rectangular markers located field proposed images trimmed accordingly order achieve uniform analysis long periods time color segmentation applied using probabilistic approach based histograms optimum color space finally object counting process performed binarized images useful applications require number objects average size using pcaps user portable device crop field take picture camera automatically cut image perform ground analysis vegetation obtaining percentage green cover pgc number plants date time gps coordinates information sent email central offices agricultural business appropriate decisions fertirrigation needs would taken pcaps intuitive user friendly developed use farm managers requiring minimal skills use mobile devices elsevier rights reserved
hitherto known integration relationship concepts traditional public sector construction contracts would improve project performance study hence examines effects contract strategies project outcomes relationship quality context public sector construction projects sydney australia also identifies relational contracting practices place certain contract strategies adopted using two pronged research design data first collected public owners private contractors consultants questionnaire survey data analyzed results validated interviews correlation analysis shows cost performance client satisfaction relationship quality among contracting parties significantly correlated contract strategies findings indicate important role contract strategies play project outcomes interpersonal relationship among practices significantly correlated contract strategies related clients consultants suggesting important role setting tone relationship project
paper examines handover process norwegian construction industry focusing commercial buildings improving handover processes reduces number conflicts increases user value improves indoor climate along securing overall building performance closing construction phases well throughout building lifetime little research found subject collective project initiated municipality trondheim case study limited single environmentally certified office building norway paper aims determine main delay defect causes finally countermeasures identified literature review along document study performed seven semi structured case specific interviews conducted addition pilot study consisting three interviews topic case respondents project managers contractor client extensive experience norwegian construction industry several causes contractor client interfaces identified among critical late changes decision making lacking understanding limitations potential design build contracts conflicting interpretation specification work along complex technical installations possible countermeasures found strict decision planning sufficient time buffers early reconciliation client expectations together sufficiently detailed specification work significant specialist knowledge complex technical coordination paper investigates little scrutinized part norwegian construction projects effort better commercial building performance profitability future research multiple construction projects would help confirm disprove findings identified countermeasures authors published elsevier ltd open access article license
flood real time social data generated various social media applications sensors enabling researchers gain critical insights important social modeling analysis problems evolution social relationships analysis emergent social processes however current computational tools address grand challenge analyzing large dynamic social networks within strict time constraints available social data effectively utilized computational issues exacerbated network size range millions nodes need analytical tools work various computational architectures existing methodologies primarily deal dynamic relationships social networks simply computing results relying massive parallel distributed processing resources maintain time constraints previous work introduced overarching parallel distributed algorithm design framework called anytime anywhere framework leverages inherent iterative property graph algorithms generate partial results whose quality increase processing time efficiently incorporates network changes paper focus closeness centrality algorithm design dynamic social networks new relationships formed due edge additions using theoretical analysis empirical results demonstrate algorithm efficiently reuses partial results reduces need computations
recent studies brain imaging analysis witnessed core roles machine learning techniques computer assisted intervention brain disease diagnosis various machine learning techniques sparse regression models proved effectiveness handling high dimensional data small number training samples especially medical problems meantime deep learning methods making great successes outperforming state art performances various applications paper propose novel framework combines two conceptually different methods sparse regression deep learning alzheimer disease mild cognitive impairment diagnosis prognosis specifically first train multiple sparse regression models trained different values regularization control parameter thus multiple sparse regression models potentially select different feature subsets original feature set thereby different powers predict response values clinical label clinical scores work regarding response values sparse regression models target level representations build deep convolutional neural network clinical decision making thus call deep ensemble sparse regression network best knowledge first work combines sparse regression models deep neural network experiments adni cohort validated effectiveness proposed method achieving highest diagnostic accuracies three classification tasks also rigorously analyzed results compared previous studies adni cohort literature elsevier rights reserved
audience profound effect dynamics communicative interactions result non human primates often adjust social decision making strategies depending audience composition given time sought test unique vocal behaviour multiple audience members affected decisions communicate address issue developed novel experimental paradigm common marmosets directly interacted multiple virtual monkeys vms represented individual marmoset distinct vocal behaviour active social signalling paradigm provided subjects opportunity interact learn behaviour network apply knowledge subsequent communicative decisions found subjects propensity interact particular vms determined behaviour audience suggests marmoset social decision making strategies highly adaptive nuances immediate communication network
many industrial processes susceptible biofouling thickness structure biofilms key factors design effective cleaning strategies novel method based fluid dynamic gauging developed measuring thickness shear stress needed removal biofilms formed cylindrical surfaces device operates test cylinder immersed liquid liquid withdrawn ejected nozzle located near biofilm surface net change liquid volume making ideal sterile aseptic operation studies using valuable liquids biofilm removal may also tested using appropriate hydrodynamic conditions calibration tests using ejection suction flows laminar regime reynolds number around indicated measurement accuracy showed good agreement computational fluid dynamics simulations device commissioned tests rseudomonas fluorescens biofilms formed high density polyethylene hdpe stainless steel cylinders diameter conditions mild shear stress around tests biofilm thickness uniform eye measurements made surface test cylinders confirmed layer thicknesses ranged effectively biofilms formed hdpe thicker formed authors published elsevier
recent years concept green building becoming popular china architects engineers opportunity actually implement green building practices paper reveals failure naturally ventilated leed certified townhouse development project china mentioned recent research house owners made great alterations purpose decoration removed minimized effectiveness natural ventilation elements original design research shows houses show international style natural ventilation design principles fully applied design localized natural ventilation strategies fully considered means computational simulation design stage also lack communication designers owners caused removal natural ventilation elements houses occupancy period authors advocate three criteria avoid failures natural ventilation design localized climate adaptive design relationship among design elements design intention awareness
menopause rating scale mrs measures quality life menopausal women compounds three dimensions assess somatic psychological urogenital menopausal related symptoms however validity scales may vary according population characteristics validations date mrs american indigenous population assess validity mrs indigenous colombian women menopause research done sample indigenous women postmenopausal women premenopausal years old mean age years mrs applied enrolled women cronbach alpha applied original proposed dimensions dimensions results factor analysis maximum likelihood methods promax rotation applied analysis mrs showed cronbach alpha somatic dimension psychological dimension urogenital score greater postmenopausal compared premenopausal versus factor analysis showed two dimensions first dimension included items accounted variance second dimension included items explaining variance cronbach alpha first dimension second dimension mrs showed high internal consistency adequate nomological validity factor analysis resulted two dimensions results evidence need better assess validity instruments different populations
context emerging market economy study examines mediating role marketing capabilities market orientation performance relationship specifically authors investigate roles product innovativeness customer relationship management crm capability research development integration brand management capabilities institutionalisation culture implementation behaviours data collected organisations authors find behaviour fully mediates effects culture product innovativeness crm capability turn enhance firm performance addition leadership quality facilitates effect culture behaviour effects product innovativeness crm capability firm performance greater presence marketing integration brand management capabilities respectively
high prevalence borderline personality disorder bpd found western prisons data exists china objective study determine lifetime prevalence bpd chinese female prison inmates associated risk factors cross sectional study conducted hunan provincial female prison data consenting inmates socio demographic clinical characteristics collected diagnosis lifetime bpd established using structural clinical interview dsm prevalence bpd cohort participating inmates multiple logistic regression analysis revealed younger age unmarried marital status higher education level fewer major medical conditions frequent personal family members drug use frequent comorbid psychiatric disorders family history psychiatric disorders positively independently associated bpd bpd common chinese female prison inmates considering adverse social consequences impact physical mental well serious attempts made diagnose bpd early improve access treatment women prisons
tremendous parallel computing ability cloud computing encourages investigators research drawbacks advantages processing large scale scientific applications workflows current cloud market composed numerous diverse public clouds local private cloud workflow scheduling one biggest challenges hybrid clouds due highly fragmented cloud market respect service provisions pricing models bandwidths paper propose online scheduling strategy continuous submitted scientific workflows hybrid clouds aims complete deadline constrained applications possible lower price firstly hierarchical iterative application partition hiap algorithm proposed partition application set dependent tasks moreover many online scheduling algorithms cooperated hiap presented finish workflows low average payment strategy takes account basic characteristics hybrid clouds bandwidth constraints data transfer cost computational cost various well known workflows used evaluating multiple scheduling algorithms results show mlf approach achieve promising performance copyright john wiley sons ltd
link prediction fundamental task social networks goal estimating likelihood link node pair applied many situations friend discovery social media platforms author recommendations collaboration networks compared numerous traditional methods paper introduces utility analysis link prediction method considering individual preferences main reason behind decision form links meanwhile also focuses meeting process latent variable process forming links accordingly link prediction problem formulated machine learning process latent variables therefore expectation maximization short algorithm adopted developed cope estimation problem performance present method tested synthetic networks real world datasets social media networks collaboration networks computational results illustrate proposed method yields satisfying link prediction results selected benchmarks particular logistic regression special case proposed method provides lower boundary likelihood function elsevier rights reserved
recent years flux switching machines fsms attractive research topic owing tremendous advantages robust rotor structure high torque high power capability suitable intensive applications however investigations focusing inner rotor structure incongruous direct drive applications study high torque power densities new outer rotor permanent magnet fsm excitation coil investigated based two dimensional fmite element analysis wheel direct drive electric vehicle based design restrictions specifications design refinements conducted original design machine using deterministic optimization approach final design machine achieved maximum torque power densities respectively slightly better inner rotor hefsm interior synchronous machine design
audio authentication critical task multimedia forensics demanding robust methods detect identify tampered audio recordings paper new technique detect adulterations audio recordings proposed exploiting abnormal variations electrical network frequency enf signal eventually embedded questioned audio recording abnormal variations caused abrupt phase discontinuities due insertions suppressions audio snippets tampering task first propose esprit hilbert enf estimator conjunction outlier detector based sample kurtosis estimated enf next use computed kurtosis input support vector machine classifier indicate presence tampering proposed scheme herein designated sphins significantly outperforms related previous tampering detection approaches conducted tests validate results using carioca corpus unedited authorized audio recordings phone calls
apremilast systematic name ethoxy methoxyphenyl methylsulfonyl ethyl acetamidoisoindoline dione inhibitor phosphodieasterase pde indicated treatment adult patients active psoriatic arthritis ability form solvates investigated three solvatomorphs namely ethyl acetate hemisolvate chnos center dot toluene hemisolvate chn center dot dichloromethane monosolvate chnos center dot chcl obtained three solvatomorphs characterized ray powder diffraction thermogravimetric analysis differential scanning calorimetry single crystal ray diffraction used analyze structures crystal symmetry packing modes stoichiometry hydrogen bonding interactions solvatomorphs addition dissolution analyses performed study dissolution rates different solvatomorph tablets vitro make comparisons commercial apremilast tablets produced celgene three solvatomorphs showed similar dissolution rates similar values similarity factor comparison dissolution profiles
minimize power consumption analog sigma delta modulator sdm fifth order loop filter sdm realized three operational amplifiers amp analog sdm shared amp applied class amplifier digital hearing aid class amplifier analog sdm realized standard cmos process maximum output power level class amplifier load omega resistance total harmonic distortion noise thd dynamic range class amplifier respectively fifth order analog sdm shared amp consumes power supply
floquet lyapunov transformation linear periodically time varying discrete time system state space representation time invariant autonomous dynamics time periodicity contained input output matrices paper shown system also state space realizations form time periodicity contained input alternatively output matrix whose state dimensions bounded product system order period length system representations applied construct state space realization optimal linear time invariant approximation time periodic system elsevier ltd rights reserved
sustainability trends buildings require new construction systems foster energy efficiency environmentally friendly buildings green roofs interesting construction systems provide aesthetic environmental benefits paper continues long term research order evaluate improve thermal behaviour sustainability extensive green roofs simultaneously research provides experimental data specific mediterranean continental climate conditions experiment consists evaluating energy consumption thermal behaviour three identical house like cubicles located puigverd lleida spain difference roof construction system roof consists conventional flat roof insulation reference case two cubicles insulation layer replaced depth extensive green roof comparing recycled rubber crumbs pozzolana drainage layer materials electrical energy consumption heat pump system measured cubicle part extensive green roof cubicles show less energy consumption respectively reference one warm periods whereas extensive green roof systems present higher energy consumption respectively compared reference cubicle heating periods elsevier ltd rights reserved
coarse grained reconfigurable architecture cgra promising parallel computing platform provides high performance high power efficiency flexibility however imperfect nested loops existing loop mapping methods often result low execution performance poor hardware utilization tackle problem paper makes three contributions highly effective general approach map imperfect loops cgra global optimization strategy search optimal initiation intervals iis powerful kernel compression method reduce oversized kernel experiment results show approach reduce total computing latency percent compared state art approaches cgra respectively moreover compilation time configuration context size acceptable practice
objective study applied human factors approach snowsport resort systems contribute understanding incidence severity pediatric snowsport head accelerations background previous research indicates low magnitude head accelerations common among snowsport participants study adds knowledge snowsport safety measuring aspects participants snowsport behavior linking head acceleration data method school aged students wore telemetry fitted helmets global positioning system gps devices snowsport activity data collected sessions total hours head accelerations recorded telemetry units compared gps generated data results study found speeds attained normally exceed testing rating helmets designed lower rates head accelerations compared earlier studies head accelerations occur generally threshold concussions conclusion pediatric snowsport head accelerations rare generally low magnitude risk head acceleration male snowboarders given recorded speeds first time participants increased targeting novice snowsport participants encourage education use protective equipment including helmets warranted post event recall good indicator experienced head impact consideration given raising standard design speed testing snowsport helmet protective devices reflect actual snowsport behaviors elsevier ltd ergonomics society rights reserved
article presents example satellite propagation modeling applying radio channel transfer function analysis described experimentally verified scientific literature simulation satellite radio channel executed employing ray tracing uniform geometric theory diffraction based method assumed urban suburban environment different polarizations derived results regarding channel transfer function analyzed via simulation wideband propagation measurement system fourier transform procedures concluded contrary ground cell radio system situations two ray models usually suffice detailed calculation considered wideband satellite radio systems moreover shown conclusions derived path loss delay spread depend specific propagation scenario also building permittivity
paper proposes new accurate exponential circuits multitude practical applications analog signal processing original method obtaining exponential function based utilization new superior order approximation functions accuracy proposed structures excellent output dynamic range strongly extended result fourth order approximation independence implemented function technological errors temperature variations best original proposed architecture exponential generator output dynamic range approximation error smaller exponential circuits designed implementing cmos technology low voltage operation minimal supply voltage power consumptions proposed exponential circuits smaller supply voltage application new exponential circuit linear vga circuit high output dynamic range presented new computational structures possibility generating continuous mathematical function presenting also increased modularity controllability reduced design costs per implemented function elsevier ltd rights reserved
objective savings agriculture governance empowerment health sagehealth study evaluate impact large scale multi level economic food security intervention health outcomes hiv vulnerability rural malawi study employed quasi experimental non equivalent control group design compare intervention participants people participating unrelated programs distinct similar geographical areas control conducted participant interviews baseline months hiv vulnerability related health outcomes food security economic vulnerability randomly selected households interviewed intervention control areas baseline months compared control group intervention led increased hiv testing hiv case finding decreased food insecurity increased nutritional diversity improved economic resilience shocks effects sustained year period significant differences change found year study period surveys randomly selected households intervention control areas although general trends toward improvement study area intervention participants outcomes significantly better results indicate intervention improve economic food security hiv vulnerability increased testing case finding leveraging resources economic development ngos deliver locally developed programs scientific funding conduct controlled evaluations potential accelerate scientific evidence base effects economic development programs health
background limited information exists comparing short term complications different inflammatory arthropathies ias total hip arthroplasty tha objectives compare perioperative complications determine common complications different subtypes compared patients osteoarthritis undergoing primary tha methods nationwide inpatient sample used identify patients undergoing elective unilateral tha including rheumatoid arthritis psoriatic arthritis juvenile idiopathic arthritis jia ankylosing spondylitis systemic lupus erythematosus sle preoperative diagnosis comorbidities postoperative complications determined using international classification disease clinical modification version codes prevalence hospital medical orthopedic complications compared patients results compared patients patients jia sle significantly inpatient medical orthopedic complications immediately tha patients jia highest orthopedic complication rate specific orthopedic complications subtype included wound dehiscence periprosthetic fractures jia increased mortality sle patients significant differences medical orthopedic complications seen patients psoriatic arthritis conclusion differences exist postoperative inpatient medical orthopedic complications among patients different types ias tha results point importance preoperative optimization patients monitoring selective postoperative complications elsevier inc rights reserved
regulation fic inco updates simplifies harmonises improves information understanding regards food labelling europe applies everyone food industry including school canteens regulation improves visibility legibility concerning allergenic foods must necessarily labelled present product allergen information non prepacked foods must also made available consumers regulation designed facilitate management children food allergies attending school although readability allergen list requires improvement use precautionary labelling must clearly circumscribed therapeutic education programs food allergy patients take account information set regulation vital public authorities ensure provisions followed reality canteen staff receive training correct implementation regulation elsevier masson sas rights reserved
engineering measures non engineering measures two complementary supports mountain torrent disaster control series approaches danger control reinforcement regulation construction management system reform recent years reservoirs traditional sense engineering measures already considerable capabilities non engineering measures water regime rainfall engineering conditions monitoring technology improved continually monitoring warning system optimized gradually risk management consciousness operability emergency plan strengthened continuously base giving full play non engineering measures functions advantages reservoir comparative analysis existing hydrological telemetric system monitoring system dam safety non engineering measures mountain torrent disaster control paper tried share integrate important information reservoir key links implementing non engineering measures mountain torrent disaster control collaborative warning disaster mitigation mode non engineering measures reservoirs mountain torrent disaster control put forward information sharing joint management collaborative prediction reservoir projects non engineering measures mountain torrent disaster control realized new idea provided solve complicated problems daily management non engineering measures mountain torrent disaster control warning information collection sudden mountain torrent disaster control event
form emotional behaviour manifests adjustment physiological acts components globe eye thus systemic analysis adjustments different methods allows establishment connections level emotional state non verbal communication research object article based biomechanics analysis binocular vision correlation means make visual non verbal expression degree visual stimulation respectively chromatic illumination movement form sizes analysis methodology based data collection stimulation procedures visual system following physiological reactions subjects target group thus dynamic stimulation strategies visual system tracking physiological reactions subjects target group applied consequently dynamic stimulation strategies visual system applied order follow reactions visual behaviour results obtained analyzed correlative methods processed image processing methods order highlight interdependency relations stimuli communication important aspect taken experimental researches highlighter correlative analysis computerized methods also final results materialized fast objective determination reporting coefficient stimulus behavioural answer authors published elsevier ltd
airway epithelial cells induce tolerogenic microenvironment modulating immune cells lung recently showed supernatant airway epithelial cells induces two marker genes alternative activation msaa respiratory myeloid cells induction partially mediated glucocorticoids secreted airway epithelial cells study investigated msaa regulation alternatively activated myeloid cells presence cytokines show yml expression boosted upon stimulation airway epithelial cell supernatant whereas msaa expression regulated suggests crosstalk glucocorticoid signaling exists blocking protein synthesis indicated dexamethasone induced novo protein synthesis required interaction glucocorticoid signaling regarding regulation using reporter gene constructs demonstrate important regulatory region within promoter found upstream start translation bioinformatic analysis identified several glucocorticoid response elements gres region analysis identified overlapping functionally active glucocorticoid receptor stat binding sites supporting cooperative effect glucocorticoids regulation findings prove plasticity complexity alternatively activated myeloid cells importance local microenvironment believe regulation special importance pulmonary system since factors glucocorticoids play role airway diseases asthma elsevier gmbh rights reserved
paper considers rainer werner fassbinder melodrama martha transnational comparative framework focusing film relationship hollywood woman film approach illustrates ways martha draws pushes narrative strategies tropes images hollywood women culture argue fassbinder takes narrative aesthetic extreme lauren berlant calls female complaintthat cultural constellation women live love love gift keeps taking viewed transnationally product fassbinder germany film like martha pushes berlant theory american woman film female complaint modes women manage intimate lives conditions patriarchy addition engaging berlant work analysis fassbinder film performance gender consequently draws theories melodrama american woman film also bertolt brecht writing gestus fassbinder ultimately show estranges hollywood woman film martha harnessing affective emotional excess woman film brechtian distanciation exaggerating social gesture playfully appropriating sirkian aesthetics martha offers spectacular critique masochism inherent gender roles patriarchy
objectives conduct preliminary comparison bioavailability two formulations commercial grade coenzyme coq powder solid formulation new oil water liquid emulsion effect antioxidants methods six healthy individuals participated randomized crossover open consecutive design week washout period pharmacokinetic parameters assessed single multiple intakes coq given daily week key findings differences pharmacokinetic parameters maximum plasma concentration area curve elimination half life statistically significant relative bioavailability increase solid coq formulation multiple dose supplementation increased plasma coq levels formulations liquid emulsion performing better fold solid liquid formulation respectively without modifications antioxidants furthermore plasma coq day statistically different formulations conclusions results obtained showed liquid emulsion improves bioavailability coq respect solid form facilitates individualized administration child turn could increase therapeutic efficacy confirmed studies
paper presents method modification single flash cycle power output thermodynamic process new method consists extracting fraction hot wellhead geothermal fluid purpose superheating saturated steam entering turbine computer programming scripts developed optimized based mathematical proposed models different components systems operating parameters separator temperature fluid wellhead enthalpy geothermal source temperature varied investigate effects net power output turbine exhaust quality systems also full exergy assessment performed new design results separator temperature optimization revealed specific net power output new design boosted turbine exhaust quality diminished compared common single flash cycle addition wells higher discharge enthalpy superheating process improve specific net power output even finally observed overall system exergy efficiency approximately raised
paper presents design implementation robust model reference controller rmrc active vibration suppression flexible structure cantilevered beam flexible beam aluminum beam cantilever configuration equipped surface bonded pzt lead zirconate titanate sensors actuators pzt piezoelectric material strong piezoelectric effect commonly used smart material since fundamental vibration mode beam major concern paper linear model represents dominant vibration mode developed used plant model control design based linear model robust model reference controller rmrc developed suppress beam vibration vibration suppression simulations experiments conducted results show proposed controller achieves effective vibration suppression flexible beam using pzt sensors actuators
suspension bridges flexible vibration sensitive structures exhibit complex multi modal vibration due usual vibration based methods could face challenge used damage detection structures paper develops applies mode shape component specific damage index detect locate damage suspension bridge pre tensioned cables important suspension bridges large structures damage long service lives could easily unnoticed capability proposed vibration based demonstrated application detect locate single multiple damages varied locations severity cables suspension bridge outcome research enhance safety performance bridges play important role transport network elsevier ltd rights reserved
study explicit finite difference method fdm based scheme developed solve maxwell equations time domain lossless medium manuscript focuses two unique aspects three dimensional time accurate discretization hyperbolic system maxwell equations three point non staggered grid stencil application parallel computing use graphics processing units gpu proposed temporal scheme symplectic thus permitting conservation hamiltonians maxwell equation moreover enable accurate predictions large time frames phase velocity preserving scheme developed treatment spatial derivative terms result chosen time increment grid spacing optimally coupled additional theoretical investigation pairing also shown finally application proposed scheme parallel computing using one nvidia tesla gpu card demonstrated benchmarks performed parallel speedup compared single core intel cpu approximately
objective design alzheimer disease associated amyloid plaques beta hyperphosphorylated tau protein tangles brain investigated possible neuroprotective role flavocoxid dual inhibitor cyclooxygenases cox lipoxygenase lox triple transgenic xtg mice subjects mice months beginning study treatment animals received daily month saline solution flavocoxid methods morris water maze used assess learning memory histology performed evidence beta plaques neuronal loss inflammatory proteins determined western blot analysis results saline treated xtg mice showed impairment spatial learning memory assessed months age increased expression inflammatory apoptotic molecules treatment xtg mice flavocoxid reduced learning memory loss increased eicosanoid production phosphorylation level amyloid precursor protein app pthr beta tau pthr perk activation nlrp inflammasome beta plaques neuronal loss compared saline treated animals conclusions pharmacological blockade cox lox able counteract progression targeting pathophysiological mechanisms downstream beta tau
strong association lipoprotein associated phospholipase pla levels atherosclerosis related diseases aim study investigate role pla ischemic stroke offer clinical evidence measuring pla helps predict risk stroke occurrence recurrence total hospitalized patients recruited including cases acute cerebral infarction aci non aci controls serum level pla aci significantly higher non aci serum level pla recurrence aci significantly higher nonrecurrence serum levels pla large artery atherosclerosis subtype highest among subtypes trial org acute stroke treatment non aci controls level pla large artery atherosclerosis cardioembolism group statistically significantly higher control cases statistically significant difference small vessel occlusion group control cases present study confirmed elevated pla level risk factor ischemic stroke chinese population serum level pla may predictive factor recurrence aci
implantation biomaterial inflammatory response involving macrophages induced behavior macrophages depends phenotype directing macrophage polarization unwanted effects may avoided study possibility modulate behavior macrophages activated biomaterials assessed vitro model primary human monocytes seeded polyethylene terephthalate polypropylene polylactic acid yarns treated medications frequently used patients rapamycin dexamethasone celecoxib pravastatin modulation adhering macrophages rapamycin resulted generally pro inflammatory effect dexamethasone caused overall anti inflammatory effect macrophages cultured either material celecoxib affected macrophages adhering polyethylene terephthalate polylactic acid pravastatin increased pro inflammatory genes macrophages cultured polypropylene polylactic acid pairwise comparison revealed macrophages adhering polylactic acid seemed susceptible phenotype modulation adhering polypropylene polyethylene terephthalate data show macrophages activated biomaterials modulated yet degree modulatory capacity depends type material combined model provides insights possibility using medication combination biomaterial direct macrophage behavior thereby possibly avoid unwanted effects implantation
inhibitory effects dihydromyricetin purified ampelopsis grossedentata melanogenesis antioxidant characteristics investigated assays tyrosinase activities melanin content mouse melanoma cells carried spectrophotometrically expression melanogenesis related proteins determined western blotting possible signaling pathways involved dihydromyricetin mediated depigmentation also examined using specific protein kinase regulators results revealed dihydromyricetin effectively suppresses intracellular tyrosinase activity decreases melanin amount cells dihydromyricetin also exhibits antioxidant properties effectively decreases intracellular reactive oxygen species ros reactive species levels results indicated dihydromyricetin inhibits melanogenesis antioxidant properties downregulating protein kinase pka protein kinase pkc mitogen activated protein kinases mapk signaling pathways present study indicates dihydromyricetin potential developed depigmentation skin care product elsevier ireland ltd rights reserved
aim study evaluate influence surface grinding sandblasting surface roughness phase chances biaxial flexural strength yttria stabilized tetragonal zirconia tzp materials thirty disk specimens cercon dentacad zirkonzahn fabricated specimens divided three groups according surface treatment control ground sandblasted surface roughness measured ray diffraction analysis performed finally biaxial flexural strength determined data analyzed two way anova weibull statistics used analyze variability strength effects surface treatments surface roughness values different material ray diffraction analysis revealed control groups composed tetragonal zirconia relative amount monoclinic zirconia control group materials transformation occurred treatments grinding decreased sandblasting increased strength control groups materials ground specimens higher weibull modulus control groups lower found ground sandblasting resulted lower compared grinding materials although increased strength roughness crystalline phase tzp materials influenced surface treatments biaxial flexural strength materials decreased grinding increased sandblasting low sandblasted groups may indicate weakening materials resulting unexpected failures wiley periodicals inc biomed mater res part appl biomater
around half inmates prison institutions antisocial personality disorder aspd recent theory proposed dysfunction endogenous opioid system eos underlies neurobiology borderline personality disorder bpd present theoretical paper based comprehensive database hand search relevant literature hypothesis extended aspd may predominant expression eos dysfunction men pathology underlies bpd women according evidence human animal studies problematic behaviours persons antisocial callous psychopathic traits may seen desperate unconscious attempts stimulate deficient eos plays key role brain reward circuits needs system met affected persons experience dysphoric mood discomfort irritability strive increase binding endogenous opioids receptors using rewarding effects aggression exertion physical manipulative power others abusing alcohol substances reward system target creating endorphin rush self harm increasing frequency sexual contacts impulsive actions sensation seeking symptoms associated aspd treated opioid antagonists like naltrexone naloxone nalmefene copyright john wiley sons ltd
therapeutic alliance perceived social support important predictors treatment response post traumatic stress disorder ptsd intranasal oxytocin administration may enhance treatment response increasing sensitivity social reward thereby therapeutic alliance perceived social support first step investigate therapeutical potential investigated whether intranasal oxytocin enhances neural sensitivity social reward ptsd patients male female police officers without ptsd included double blind randomized placebocontrolled cross fmri study intranasal oxytocin placebo administration social incentive delay task conducted investigate neural responses social reward punishment anticipation feedback placebo ptsd patients showed reduced left anterior insula responses social rewards happy faces compared controls oxytocin administration increased left responses social reward ptsd patients ptsd patients longer differed controls placebo furthermore ptsd patients oxytocin increased responses social reward right putamen normalizing abberant insula responses increasing putamen responses social reward oxytocin administration may enhance sensitivity social support therapeutic alliance ptsd patients future studies needed investigate clinical effects oxytocin
dna topoisomerase topoi candidate autoantigen diffuse cutaneous systemic sclerosis dcssc associated fatal lung disease dendritic cells dcs contribute bleomycin induced lung fibrosis however possibility topoi loaded dcs involved initiation perpetuation dcssc explored show immunization topoi peptide loaded dcs induces anti topoi autoantibody response long term fibrosis mice repeatedly immunized unpulsed dcs dcs loaded either topoia topoib peptides selected different regions topoi week initial immunization topoia dcs topoib dcs immunization induced mixed inflammation fibrosis lungs skin late time point week topoia dcs topoib dcs groups displayed increased alpha smooth muscle actin expression lungs dermis along skin fibrosis distal site injection compared unpulsed dcs topoi peptide immunized groups developed igga anti topoi autoantibody response week signs perivascular peribronchial parenchymal pulmonary inflammation already observed topoia dcs group together transient elevation bronchoalveolar lavage cell counts expression cxcl production biomarker early human dcssc collectively topoi peptide dcs induce progressive autoantibody response well development protracted skin lung dcssc like disease pronounced lung inflammation transient cxcl expression precede fibrosis development immunization strategy uses self immune system autoantigen help investigate pathogenesis complex autoimmune disorder unmet medical needs
nonapeptides isotocin arginine vasotocin avt along mammalian homologs oxytocin arginine vasopressin well known regulators social behaviors across vertebrate taxa however little known involvement paternal care measured effect avt via receptor antagonist paternal behaviors primarily paternal teleost amphiprion ocellaris also measured effect receptor antagonist aggression dyadic contests two non reproductive fish assess specificity effect paternal behaviors individual differences levels paternal behaviors nips fanning eggs proportion time nest consistent across spawning cycles treatments administered receptor antagonist severely reduced paternal behaviors effect aggression whereas avt receptor antagonist increased paternal behaviors results support idea signaling crucial expression paternal behavior ocellaris based previous study showing avt via antagonist decreases aggression dyadic contests hypothesize antagonist enhances paternal behavior indirectly reducing vigilance aggression thereby alleviating effort directed towards competing behaviors allowing increased expression paternal behaviors elsevier inc rights reserved
excellent results reported mini gastric bypass adopted modified one anastomosis gastric bypass oagb concept herein approach results long term follow initial patients submitted laparoscopic oagb analyzed year mean age years body mass index bmi without previous simultaneous abdominal operations previous simultaneous performed revisions mean operating time min follows primary procedure operations revisions intraoperative complications led conversions complications prompted operations solved conservatively long term complications occurred deaths thirty day late readmission rates cumulative years highest mean percent excess weight loss years years postoperatively mean bmi decreased time frames remission improvement comorbidities achieved patients quality life index satisfactory parameters months onwards laparoscopic oagb safe effective reduces difficulty operating time early late complications roux gastric bypass long term weight loss resolution comorbidities degree satisfaction similar results obtained aggressive complex techniques currently robust powerful alternative bariatric surgery
mini radar launched lunar reconnaissance orbiter imaged lunar surface using hybrid polarimetric transmitting one circular polarization receiving linear polarizations earth based radar operating frequency acquired data terrains using circular polarized transmit waves sampling circular polarizations lunar targets viewing geometry nearly polarimetry derived mini earth based data similar however discovered considerable difference circular polarization ratio cpr values two data sets investigate possible causes discrepancy including cross talk channels sampling ellipticity mini transmit wave find none reproduce observed cpr differences though nonlinear block adaptive quantization function used compress data significantly distort polarimetry products comparison earth based data sets acquired using two different sampling modes sampling received linear polarizations sampling circular polarizations suggests cpr differences may partially due sampling data different receive polarimetry bases
background current guidelines nutritional rehabilitation hospitalized restrictive eating disorder patients recommend cautious approach refeeding several studies suggest higher calorie dietsmay safe effective traditionally excluded severely malnourished patients goal study evaluate safety higher calorie nutritional rehabilitation protocol nrp broad sample inpatients restrictive eating disorders including severely malnourished methods retrospective chart review conducted among eating disorder inpatients january march patients started lower calorie diet kcals day calorie prescription admission based physician clinical judgement sample included patients aged years dsm restrictive eating disorder severely malnourished expected body weight ebw required tube feeding admission included multivariable regression models used determine whether level nutritional rehabilitation associated hypophosphatemia hypomagnesemia hypokalemia results sample included patients mean age years ebw majority started higher calorie diets mean kcal day controlling rate calorie change initial ebw age race ethnicity insurance diagnosis tube placement higher calorie diets associated hypophosphatemia hypomagnesemia hypokalemia admission within first increased risk hypophosphatemia admission associated lower baseline ebw conclusion higher calorie nrp tolerated broad population inpatients restrictive eating disorders lower ebw admission important predictor hypophosphatemia initial calorie level larger studies required demonstrate safety higher calorie diets severely malnourished patients
present research uses social relations model approach focus individual differences perceptual confidence person confidence impressions others across two samples group interactions found majority variance perceptual confidence explained individual differences people tended perceive others perceiver effects smaller percentage variance explained differences people tended perceived others target effects individual differences stable time related relevant personality measures group outcomes together results demonstrate although perceptual confidence may substantially related accuracy exists stable individual difference dimension important consequences social interactions elsevier inc rights reserved
study designed examine intervene student behaviours promote democratic inclusive participatory focus within sport education achieve increased understanding changes within student behaviours collaborative participatory action research methodology applied provide voice students agents change research progressed throughout entire school year cast two stages first season basketball provided baseline respect issues equity inclusion followed intervention stage seasons handball soccer volleyball identified issues acted upon based upon issues unearthed action research cycles intervention focused legitimating different levels participation reconfiguration learning content peer teaching activities competition formats discussion inequity exclusion gender stereotyping discrimination emerging group dynamics within focus groups interviews promotion positive leadership behaviours student coaches leadership seminars conducted outside gym end year significant evidence inclusive membership accompanied development mutual trust among students shared contributions towards common inclusive goal close interrelatedness found game competence development trajectories participation sense membership restructuring power relations sharing knowledge investment dominant higher skilled students towards inclusive team goals sport education curriculum alone insufficient dismantle deeply rooted negative cultural influences community based sports influenced equity inclusion however planning implementing specific intervention used educational resources sport education proactively possible promote inclusive equitable learning environment
suwabe mistretta krull bradley pre postnatal differences membrane action potential ion channel properties rostral nucleus solitary tract neurons neurophysiol first published august doi little known prenatal development rostral nucleus solitary tract rnst neurons rodents factors influence circuit formation morphological electrophysiological techniques vitro investigated differences biophysical properties rnst neurons pre postnatal rats embryonic day postnatal day developmental changes passive membrane action potential properties emergence maturation ion channels important neuron function characterized morphological maturation rnst neurons parallels changes passive membrane properties mean soma size dendritic branch points neurite endings neurite length increase prenatally whereas neuron resting membrane potential input resistance time constant decrease dendritic spines hand develop birth discharge patterns alter pre postnatal stages neurons generated single ttx sensitive voltage gated depolarized higher discharge rate appeared older stages amplitude half width rise fall times change development responses current injection revealed number voltage gated conductances embryonic rnst including hyperpolarization activated inward current low threshold current initiated spikes hyperpolarization activated transient outward potassium current also present developing neurons although properties channels change development present synapses form therefore contribute initial establishment neural circuits well changing electrophysiological properties developing rnst neurons
electrical stimulation greater occipital nerve gon recently shown promise effective non pharmacological prophylactic therapy drug resistant chronic primary headaches neurobiological mechanisms underlying anticephalgic action elucidated considering spinal trigeminal nucleus stn key segmental structure playing prominent role pathophysiology headaches present study evaluated effects gon electrical stimulation ongoing evoked firing dura sensitive stn neurons experiments carried urethane chloralose anesthetized paralyzed artificially ventilated male wistar rats extracellular recordings made neurons within caudal part stn received convergent input ipsilateral facial cutaneous receptive fields dura mater gon experiment five various combinations gon stimulation frequency intensity tested successively min interval parameter sets preconditioning gon stimulation train pulses applied recording produced suppression ongoing activity stn neurons responses electrical stimulation dura mater inhibitory effect depended mostly gon stimulation intensity maximally pronounced stimulus applied thus gon stimulation induced inhibition trigeminovascular nociceptive processing level stn demonstrated first time data obtained contribute deeper understanding neurophysiological mechanisms underlying therapeutic efficacy gon stimulation primary headaches
background objective high fidelity medical simulation source stress participants aim study assess repeated simulated courses decrease perceived stress physiological stress level increase performance anaesthesiology registrars method fourteen anaesthesiology specialty registrars participated individually three successive sessions crisis simulation operating room participants perceived stress levels measured self assessment simple numerical scale stress maximum stress physiological stress estimated via maximal heart rate measured holter system technical non technical performances also assessed data expressed medians interquartile ranges extremes median iqr min max results first third session simulation repetition associated decrease perceived stress versus session session respectively whereas physiological stress assessed maximum heart rate remained unchanged beats per minute beats per minute sessions respectively also significant inverse correlation perceived stress levels experienced registrars session non technical performance conclusion observed reduction perceived stress levels experienced registrars physiological stress unchanged repeating simulation sessions combining simulated practice debriefing learning simulation could improve perceived stress management critical situations societe francaise anesthesie reanimation sfar published elsevier masson sas rights reserved
classical secret key generation model common randomness generated two terminals based observation correlated components common source keeping secret non legitimate observer assumed statistics source known participants paper secret key generation based compound source studied realization source statistic unknown protocol guarantee security reliability generated secret key simultaneously possible realizations compound source single letter lower bound secret key capacity finite compound source derived function public communication rate constraint multi letter capacity formula computed finite compound source case public communication unconstrained finally single letter capacity formula derived degraded compound source arbitrary possibly infinite set source states finite set marginal states
abstract conceptual feature acf framework predicts word meaning represented within high dimensional semantic space bounded weighted contributions perceptual affective encyclopedic information acf like latent semantic analysis amenable distance metrics two words applied predictions acf framework abstract words using eyetracking via adaptation classical visual word paradigm vwp healthy adults selected lexical item related probe word item written word array comprising target three distractors relation probe four words determined using semantic distance metrics derived acf ratings eye movement data indicated word semantically related probe received longer fixations relative distractors importantly sets participants provide overt behavioral response fixation rates nonetheless significantly higher targets distractors closely resembling trials expected response given furthermore acf ratings based individual words predicted eye fixation metrics probe target similarity least well latent semantic analysis ratings based word occurrence results provide validation euclidean distance metrics derived acf ratings measure one facet semantic relatedness abstract words suggest represent reasonable approximation organization abstract conceptual space data also compatible broad notion multiple sources information restricted sensorimotor emotion information shape organization abstract concepts adapted vwp potentially metacognitive task classical visual world paradigm argue offers potential utility studying abstract word comprehension
sensitivities structural response due variation design parameters prerequisite majority algorithms used fundamental problems engineering system uncertainties identification probabilistic assessments etc paper presents concept probabilistic sensitivity suspension bridges respect near fault ground motion near field earthquake ground motions large amplitude spectral accelerations occur long periods many suspension bridges significant structural response modes two different types suspension bridges bosporus humber bridges selected investigate near fault ground motion effects suspension bridges random response sensitivity analysis modulus elasticity selected random design variable strong ground motion records kocaeli northridge erzincan earthquakes selected analyses stochastic sensitivity displacements internal forces determined using stochastic sensitivity finite element method monte carlo simulation method stochastic sensitivity displacements responses obtained two different suspension bridges subjected near fault strong ground motions compared seen results near fault ground motions different impacts stochastic sensitivity responses suspension bridges stochastic sensitivity information provides deeper insight structural design used basis decision making
article cause histology imaging characteristics clinical presentation treatment lesions thoroughly discussed bone marrow edema generic term classically used describe high signal intensity alterations detected magnetic resonance fluid sensitive sequences significance bone marrow edema patient clinical condition prognosis affected joint increasingly investigated discussed situations characterized subchondral insufficiency receiving increasing attention recent studies found important correlations bone marrow lesions patient pain osteoarthritis progression conservative treatment based anti inflammatory analgesic uses according patient pain combined reduced load affected limb regarding surgical treatment subchondroplasty option still development albeit promising initial results
study citric acid employed low molecule organic acid influence adsorption performance phosphorus obtained magnetite factors including initial phosphate concentrations dosage citric acid value ion strength contact time temperature examined detail results indicated dissolution anion sodium dodecyl sulfate sds covering surface magnetite slight decrease level superior structure magnetite modification occurred dependence phosphate adsorption impeded surface potential magnetite positively increased added non linear regression langmuir freundlich model fitted well thermodynamics opposite adsorption process function temperatures without addition due decrease active energy active mobility phosphate ion finally declining adsorption efficiency increasing cycles observed phosphate removal approximately finished small change addition improvements removal efficiency phosphorus modified iron oxide removal anionic sds increased surface positive charge especially dissolution element solution form precipitate phosphorus ions enhanced stability magnetite also promoted high removal efficiency phosphorus implications phosphate removal extended field phosphate pollution notorious urgent elsevier rights reserved
paper proposes novel analog circuit verification approach using causal reasoning verify analog circuits flow begins mining causal reasoning steps design plan produced circuit including starting ideas design step sequence justification topological structures corresponding starting ideas design step sequences verified individually replacing related devices ideal amplifier model circuit performance evaluated spectre simulation comparing simulation results reveals incorrect functional issues performance drawbacks negative causes certain starting ideas design steps might omitted design process paper discusses three operational amplifier designs realized cmos technology illustrate verification approach
background primary bile acid diarrhoea bad associated increased bile acid synthesis low fibroblast growth factor fgf bile acid sequestrants used therapy poorly tolerated may exacerbate fgf deficiency aim purpose study evaluate pharmacological effects conventional sequestrants colonic release formulation preparation colestyramine bile acid metabolism bowel function patients bad methods patients seven day selenium homocholic acid taurine sehcat scan retention randomised double blind protocol two weeks treatment twice daily placebo thirteen patients taking conventional sequestrants start study symptoms recorded serum fgf alpha hydroxy cholesten one measured results median serum fgf conventional sequestrant treatment lower baseline values bad conventional sequestrant treatment higher bad changes seen starting withdrawing improved diarrhoeal symptoms median reduction points likert scale compared placebo conclusions serum fgf suppressed bile acid production regulated conventional bile acid sequestrants colonic release formulation colestyramine produced symptomatic benefit patients bad
analytically study schrodinger type nonlinear evolution equations improved tan phi expansion method explicit solutions derived include optical bright solitons dark solitons singular solutions singular triangular periodic solution exact particular solutions containing four types hyperbolic function solution trigonometric function solution exponential solution rational solution obtained solutions comparing methods recently method developed searching exact travelling wave solutions nonlinear partial differential equations shown method help symbolic computation provide straightforward powerful mathematical tool solving problems nonlinear optic elsevier gmbh rights reserved
energy storage systems established capability overcome problems caused intermittent nature renewable sources integrated existing grid voltage frequency control well load shifting done using grid level storage systems incorporated renewable sources effectively serve system energy sink source operational use energy storage grid level support wind electric generator weg demonstrated study battery storage supported weg along controllers modelled artificial neural network controller inherent learning capability developed regulate power flow wind generator utility grid proposed algorithm corresponding controller simulated matlab simulink implemented dsp processor real time data exchange simulink floating point dsp processor tmsf realised using board jtag emulator hardware implementation using dsp processor presented work establishes efficacy proposed control strategy real time applications
days number processors computer systems increasing fast speed different manufacturers producing computers manycore processors turn manycore computer systems require new operating system solve problems commodity operating systems commodity operating systems originally made single dual multi cores systems lower performance scalability problem higher number cores hundreds thousands number regard scholars different research institutions trying develop solutions existing problems among commodity operating systems recently emerging manycore processor paper intends see manycore operating systems main objective paper compare contrast manycore operating systems analyze experimental results give summarizing concepts manycore operating systems developing either scratch amendment existing commodity operating systems operating systems projects develop manycore operating system scratch need lots effort generally new approaches applied use completely new technical approaches development oses increased number cores operating systems like fos barrelfish examples operating systems developed scratch hand operating system projects focus commodity oses problems increased number cores projects amend commodity operating systems used collectively therefore main task preparing systems play important role amendment compared operating system development approach approaches simple manycore oses used operating systems like fusedos cerberus others type operating systems respect paper see reason behind selection either two approaches also provide highlights basic structural differences among existing manycore operating systems order catch philosophy behind
paper describes development hardware loop hil test platform performance assessment pmu based sub second linear real time state estimator rtse active distribution networks adns estimator relies availability data coming phasor measurement units pmus applied balanced unbalanced adns paper first illustrates architecture experimental hil setup fully designed authors consists real time simulator rts models electrical network model well measurement infrastructure composed virtual pmus virtual devices stream data real phasor data concentrator pdc suitably coupled discrete kalman filter state estimator dkf using experimental setup paper discusses performance assessment whole process terms estimation accuracy time latencies rts real adn located netherlands modeled together associated pmus
paper present bio inspired parallel implementation solution problem looking representative geometrical objects homology groups binary image extended hgbi problem extended version well known problem homology theory particular given binary image black connected components representative curves holes components obtained labelled aim new technique labelling connected components binary image presented order compute solution formal framework uses techniques membrane computing implementation done hardware architecture called compute unified device architecture cuda computational complexity proposed solution respect input image size similar finally examples applications also presented
aggressive behavior assumed associated certain patterns social information processing theories link aggression tendency interpret ambiguous stimuli hostile enhanced sensitivity anger others assume insufficient ability perceive emotional expressions particularly fear despite compelling evidence support theories previous study directly investigated predictions made two accounts aggressive populations aim current study test processing patterns angry fearful facial expressions violent offenders vos healthy controls ctls association self reported aggression psychopathy scores experiment assessed perceptual sensitivity neutral emotional angry fearful happy blends task require categorization indication whether stimulus neutral emotional experiment assessed categorization performance ambiguous fearful happy angry happy blends group differences revealed experiment experiment indicated deficit categorization ambiguous fearful blends group importantly deficit associated self reported psychopathy aggression ctl group current study provides evidence deficient categorization fearful expressions association self reported aggression psychopathy vos support heightened sensitivity anger furthermore current findings indicate deficit tied categorization detection stages social information processing
indices developed assess discomfort specific behavioral violations gender heteronormative gender roles gender identity sexual orientation three component model proposes specific threats social status mechanisms gender based prejudice used assess whether homophobia transphobia triggered non gender heteronormative social identity status outgroup member perceived violations specific gender heteronormative behaviors sample female male gender heteronormative college undergraduates path analyses showed homophobia particularly associated discomfort violations sexual orientation norms transphobia particularly associated discomfort violations gender identity norms men women discomfort sexual orientation norms significantly mediated relationships linking right wing authoritarianism benevolent sexism homophobia discomfort violations gender identity norms significantly mediated relationships linking right wing authoritarianism benevolent sexism transphobia discomfort sexual orientation norms significantly mediated relationships religious fundamentalism homophobia men discomfort mediated relationship benevolent sexism homophobia women significant direct path physical aggression proneness homophobia found men
three dimensional modeling foundation graphic expression virtual reality digital landscape article explores key technologies methods applications three dimensional modeling virtual plant digital landscape classifies manual modeling technology program generation technology software automatic generation technology measurement based reconstruction technology researching visual simulation landscape plant elements three dimensional modeling theories computer graphics main purpose provide three dimensional expression landscape design landscape planning theoretical guide well promote sustainable development virtual plant modeling technology field landscape architecture
aim study assess whether oral liquid levothyroxine would correct tablet levothyroxine malabsorption induced calcium iron two sequestrants levothyroxine nineteen adult hypothyroid patients tablet levothyroxine malabsorption caused calcium iron supplements switched tablet liquid levothyroxine dose primary outcomes significantly lower mean serum thyroid stimulating hormone liquid compared tablet formulation significantly greater rate serum thyroid stimulating hormone less equal mean follow weeks tsh lower liquid levothyroxine compared tablet levothyroxine calcium group iron group thyroid stimulating hormone levels patients calcium group iron group frequent post switch compared pre switch thyroid stimulating hormone levels compared pattern held comparing first liquid levothyroxine thyroid stimulating hormone levels first tablet levothyroxine thyroid stimulating hormone levels corresponding rates thyroid stimulating hormone levels target liquid levothyroxine resistant sequestration calcium iron high rate thyroid stimulating hormone normalization already first check weeks avoid frequent adjustments levothyroxine doses assays thyroid stimulating hormone consequent financial savings
background converging lines evidence established relationship exposure ambient light mood state mood disorders view association mood disorder affective disposition study relationship temperament depressive cyclothymic hyperthymic irritable anxious daily light exposure closely examined methods fifty six subjects completed japanese standardized version temperament evaluation memphis pisa paris san diego auto questionnaire version temps illuminance daytime using actigraphy results cyclothymic temperament scores significantly negatively associated illuminance daytime whereas hyperthymic temperament scores significantly positively associated illuminance daytime limitations sample size relatively small healthy subjects patients conclusions findings suggest illuminance daytime may related cyclothymic hyperthymic temperaments associations lie opposite directions case seems important consider individual patients temperaments light therapy used treat depressive episode studies required determine temperaments associated illuminance elsevier rights reserved
thyroid hormones influence functioning central nervous system furthermore cholinergic purinergic systems also extensively involved brain function context quercetin polyphenol antioxidant neuroprotective properties study investigated effects mmi induced hypothyroidism ntpdase nucleotidase adenosine deaminase ada acetylcholinesterase ache activities synaptosomes rats whether quercetin prevent mmi concentration administered days drinking water animals divided six groups control water control quercetin control quercetin methimazole water mmi methimazole quercetin mmi methimazole quercetin mmi day hormonal dosing performed confirm hypothyroidism animals subsequently treated quercetin days ntpdase activity altered mmi group however treatment quercetin decreased atp adp hydrolysis mmi mmi groups nucleotidase activity increased mmi group treatments quercetin decreased nucleotidase activity ada activity decreased mmi groups furthermore ache activity reduced groups hypothyroidism vitro tests also demonstrated quercetin per decreased ntpdase nucleotidase ache activities study demonstrated changes nucleotidase ache activities indicating purinergic cholinergic neurotransmission altered condition addition quercetin alter parameters may promising natural compound important neuroprotective actions hypothyroidism
reduction iron ore coal composite pellets multi layers rotary hearth furnace rhf limited heat mass transfer effect various parameters like pellet shape size bed packing material supposed influence heat mass transfer pellet bed investigated reduction behaviour iron ore coal composite pellets degrees min laboratory scale rhf reduced pellets characterised weight loss measurement estimation shrinkage porosity qualitative quantitative phase analysis xrd significant difference degree reduction observed layer wise pellet bed variation pellet shape size pellet bed without packing material packed coal demonstrated higher degrees reduction compared pellet bed packed graphite sand
research note reflect researcher trauma discipline geography explore ways build framework researcher self care facilitating conversations mental health collaboration human research ethics committees professional organisational development services workplace health safety units
ball screw mechanisms widely applied different industries due capability achieving precise positioning performance well long travel range positioning travelling contouring actions however mechanism exhibits nonlinearities micro movement paper disturbance observer controller pddo proposed ball screw mechanism achieve fast precise positioning performance macrodynamic mathematical model mechanism derived pddo controller designed achieve fast positioning micro travel range robustness controller mass examined experimental results demonstrated pddo controller achieves better performance fast tracking working range compared pid controller besides pddo controller also demonstrated robustness presence mass changes
deep vein thrombosis dvt prevalent disease patients dvt develop postthrombotic syndrome pts within months initial diagnosis dvt gold standard diagnosis pts clinical signs include pitting edema hyperpigmentation phlebectatic crown venous eczema varicose veins several scoring systems developed diagnostic evaluation conservative treatment includes compression therapy medications lifestyle modification exercise compression therapy mainstay proven noninvasive therapy patients pts prescribed compression stockings bandaging adjustable compression wrap devices intermittent pneumatic compression medications may used prevent treat pts include anticoagulation anti inflammatories vasoactive drugs antibiotics diuretics exercise weight loss smoking cessation leg elevation also recommended areas research include duration compliance strength compression stockings prevention pts dvt use intermittent compression devices optimal medical anticoagulant regimen endovascular therapy role newer anticoagulants anti inflammatory agents
purpose review address current treatment unmet needs psoriatic arthritis psa examine existing randomized controlled trials rcts consider options new trial designs challenges implementation recent findings therapeutic options psa rapidly increased continues need clinical trials test new therapies establish optimal treatment strategies order improve care patients psa addition data needed select best therapy given patient clinical practice consideration alternative outcome measures also needed summary despite rapid expansion number therapy options available still much learned treat individual patient psa
alcohol implicated intergroup aggression hostility effect consuming alcohol relative placebo hostile cognitive biases toward social category typically stereotyped threatening hostile middle eastern men tested undergraduates consumed either intoxicating dose alcohol brac vol placebo played shooter game asked shoot targets holding guns targets holding harmless objects half targets white half middle eastern predicted alcohol consumption relative placebo increased participants bias shoot middle eastern targets affect shooter bias white targets findings suggest alcohol may heighten aggressive biases toward outgroups stereotyped threatening hostile
result severe environmental pressure stringent government regulations refined energy management vehicles become inevitable improve vehicle fuel economy paper presents bus based energy management system electrical system internal combustion engine vehicles model intelligent alternator model lead acid battery discussed according models energy management vehicular electrical system formulated global optimal control problem aims minimize fuel consumption pontryagin minimum principle applied solve optimal control problem realize real time control strategy electrical energy management vehicles control strategy change output intelligent alternator battery changes electrical load driving conditions real time experimental results demonstrate compared traditional open loop control strategy proposed control strategy vehicle energy management effectively reduce fuel consumption fuel consumption per decreased approximately
since beginning millennium shale gas extraction horizontal drilling hydraulic fracturing boosted gas production changing global energy markets leading low natural gas oil prices following expansion industry countries poland china exploring supporting extraction way secure energy independence increasingly unstable geopolitical context effective transition substitute coal moving towards renewable energy market however important environmental concerns associated shale gas production including atmospheric pollution air quality issues risks water pollution nuisance population caused road traffic noise water management one challenging problems since hydraulic fracturing requires millions liters water produces high volumes liquid effluents variable compositions rates present review focuses characteristics wastewater options existing minimize environmental impacts moment deep well injection use commonly employed strategies wastewater stricter regulations regions require treatment partial treatment reuse preferred option feasible otherwise techniques mechanical vapor compression thermal distillation forward osmosis may needed order meet requirements discharge elsevier ltd rights reserved
study carried investigate morphological development kidney foetal stage camelus dromedaries biometrical analysis experiment thirthy numbers camelus dromedaries embryoes selected based crown rump length subsequently divided age groups consisting animals group group days group days group iii days group days group days group days foetus days kidneys demonstrated circle shape renal pelvis evident kidneys study days old foetuses bean shape kidneys present renal pelvis distinct extensive well developed ureter originated middle pelvis left right kidneys days old foetus length width thickness kidneys increased significant variation measurements parameters resulted
modern multicore embedded systems often execute applications rely heavily concurrent data structures selection efficient concurrent data structure implementations specific application usually complex time consuming task design decision often affects performance energy consumption embedded system various occasionally unpredictable ways complexity normally addressed developers adopting hoc design solutions often suboptimal yield poor results face problem propose semi automated methodology optimization applications utilize concurrent data structures based design space exploration proposed approach evaluated using microbenchmarks real world applications executed multicore embedded systems different architectural specifications results show identify various trade offs different data structure implementations used optimize applications rely concurrent data structures
fusarium head blight fhb global problem small grains agriculture results yield losses seriously produces harmful toxins enter food chain study builds previous research identifying within field humidity important factor infection processes fusarium species mycotoxin production environmental variables describing topographic control humidity twi soil texture related moisture electrical conductivity eca canopy humidity density ndvi explored relationship fungal infection rates abundance trichothecene producing fusarium spp determined tri gene copies mycotoxin accumulation field studies performed four field sites northeastern germany wet year high fusarium infection rate resulted high abundance trichothecene producing fungi well high concentrations mycotoxins simultaneously fusarium spp inhibited development filamentous fungi overall heterogeneous distribution pathogen infections mycotoxin concentrations displayed field landscape ndvi serves important predictor occurrence phytopathogenic fusarium fungi mycotoxins field landscape scale addition eca reflects distribution frequently occurring mycotoxin deoxynivalenol within fields landscapes cases twi found significant variable models results extend knowledge suitable indicators fhb infection mycotoxin production within field
epithelial appendages palatal rugae develop mouse palatogenesis epithelial thickening pattern formation recently patterned formation nine rugae observed together specific expression patterns shh rodents however crucial evidence found direct association shh expression distinct structural formation rugae order reveal possible relationships investigated morphological changes rugae expression patterns shh directly vitro organ culture embryonic day days compare examine diverse growing aspects palate rugae carefully observed detailed morphogenesis cell proliferation rugae occurring days cultivation dii micro injections revealed middle part palate adjacent upper molar forming region contributed formation subsequent structure rugae extensive cell rearrangement proliferation within epithelium preferred anteroposterior direction results also defined intimate relationship shh expression rugae formation
electrodynamic bearings operate without active control means case dynamic behavior bearing relies solely passive electromagnetic phenomena studied using specific models recent years linear state space representations linking forces relative motion stationary moving parts bearing obtained without making assumption kinematics rotor axis however significant limitations remain regarding topology bearing regards heteropolar bearings radial magnetic field latter refers number winding phases number pole pairs permanent magnets pms winding presence pms rotor stator presence ferromagnetic yoke attached winding paper presents model free limitations compared existing models additional complexities introduced state space representation result dynamics wider range heteropolar electrodynamic bearings studied linear model
report new prodrug micelle based approach model hydrophobic non steroidal anti inflammatory drug nsaid ibuprofen ibu tethered amphiphilic methoxy polyethylene glycol polypropylene fumarate mpeg ppf diblock copolymer via hydrolytic anhydride linkages potential controlled release applications nsaids synthesized mpeg ppf ibu polymer drug conjugates pdc demonstrated high drug conjugation efficiency similar self assembled form micellar nanostructures aqueous medium critical micelle concentrations ranging entrapment efficiency ibu prepared pdc micelles high crosslinking prodrug micelles dimethylaminoethyl methacrylate conferred responsive characteristics responsive pdc micelles averaged size exhibited concomitant changes size upon incubation physiologically relevant mildly acidic conditions ibu release observed increase increasing acidic conditions could controlled varying amount crosslinker used furthermore prepared mpeg ppf based micelles demonstrated excellent cytocompatibility cellular internalization vitro importantly pdc micelles exerted anti inflammatory effects significantly decreasing monosodium urate crystal induced prostaglandin levels rabbit synoviocyte cultures vitro cumulatively results indicate new prodrug micelle approach promising nsaid based therapies treatment arthritis cancer elsevier inc rights reserved
monitoring chronic wound healing challenging issue clinicians across world moreover health cost burden cware escalating disturbing rate due global rise population elderly diabetic cases conventional approach includes visual contour sketches rarely tracings however conventional techniques bring forth infection pain allergies furthermore methods subjective well time consuming nowadays non touching non invasive monitoring system based imaging techniques gaining importance reduce patients discomfort also provide rapid wound diagnosis prognosis review provides survey different types characteristics healing mechanism multimodal non invasive imaging methods used diagnosis prognosis current clinical practices well personal health systems health health monitoring discussed
paper describes analysis calibration procedure computational optical system applied dimensional monitoring april suspension bridge lisbon portugal analysis includes displacement optical measurement approach calibration method reference standard prototype experimental setup evaluation measurement uncertainty described including input measurement uncertainty contributions related experimental design use monte carlo numerical simulation tool determination measurement uncertainty related calibration test well sensitivity analysis identify major sources uncertainty conclusions drawn suitability calibration method reference standard prototype
background objectivesthe expression disintegrin metalloproteinase adam associated several inflammatory diseases elevated adam levels shown gingival crevicular fluid patients chronic periodontitis objective study investigate adam expression chronic periodontitis tissues compared normal tissues adam expression inductive mechanism examined human gingival epithelial cells hgecs human gingival fibroblasts material methodstotal rna protein extracted gingival biopsies patients chronic periodontitis healthy volunteers adam mrna protein expression analyzed real time polymerase chain reaction immunoblotting immunohistochemistry adam expression control stimulated cells presence absence specific inhibitors mitogen activated protein kinase pathways assayed real time polymerase chain reaction immunoblotting flow cytometry immunofluorescence resultsadam mrna protein expression chronic periodontitis tissues significantly greater normal tissues significantly increased adam expression detected gingival epithelium chronic periodontitis tissues adam mrna expression hgecs human gingival fibroblasts significantly induced stimulation fusobacterium nucleatum partially via mitogen activated protein kinase pathway adam expression cell lysates surface hgecs induced stimulation nucleatum conclusionadam expression increased inflamed chronic periodontitis tissues localized within gingival epithelium consistent upregulation adam expression nucleatum stimulated hgecs suggesting possible role adam innate immunity periodontal tissue
context aware mobile systems data past user behaviour use device give critical information scale data may large must quickly searched retrieved compression powerful tool storing indexing data text documents powerful algorithms using structured storage achieve high compression rapid search retrieval byte stream techniques provide higher compression lack indexation slow retrieval location common form context frequently used research prototypes tourist guide systems location aware searching adaptive hypermedia paper present exploration record based compression global positioning system cps data reveals significant technical limitations achieved mobile devices discussion benefits different compression techniques cps data
background fundamental problems personality disorders diagnostic system previous version dsm led revision dsm therefore multidimensional system proposed diagnosis personality disorder features dsm dimensional approach dsm personality disorders diagnosis based levels personality functioning criteria personality trait domains criteria objectives purpose study firstly examine dsm levels personality functioning antisocial borderline personality disorders second explore levels personality functioning patients antisocial borderline personality disorders better predicted severity others patients methods study cross sectional design participants consisted individuals antisocial borderline personality disorders recruited tehran prisoners clinical psychology psychiatry centers razi taleghani hospitals tehran iran sample selected based judgmental sampling scid scid dsm levels personality functioning used diagnose assess personality disorders data analyzed correlation multiple regression analysis statistical analyses performed using spss software results firstly found dsm levels personality functioning strong correlation antisocial borderline personality symptoms specially intimacy self directedness secondly findings showed identity intimacy selfdirectedness significantly predicted antisocial personality disorder severity results showed intimacy empathy good predictors borderline personality disorder severity well conclusions overall findings showed levels personality functioning significant predictor personality disorders severity results partially confirm existing studies
first order high order correlation power analysis attacks shown severe threat cryptographic devices serve security measure evaluation comparison security oriented implementations properly designed data dependent delays used barrier attacks paper introduces security oriented delay assignment algorithm mitigating single multibit attacks algorithm enables reduction correlation processed data consumed current utilizing data dependent delays source correlated noise done minimizing area overhead propagation time power show security level new algorithm provides area efficiency higher frequencies permuted path delay assignment random embedding delay elements
actual threat passive millimetre wave mmw detection guidance enhance survivability ground target future battlefield mmw passive stealth technology research conducted necessity analyzed certified mmw passive detection distance analyzed base target radiation characteristic testing principle main direction mmw passive stealth shape materials behavior control pointed actual control methods analyzed
pathwhiz web server built facilitate creation colorful interactive visually pleasing pathway diagrams rich biological information pathways generated online application machine readable fully compatible essentially web browsers computer operating systems uses specially developed web enabled pathway drawing interface permits selection placement different combinations pre drawn biological biochemical entities depict reactions interactions transport processes binding events palette entities consists chemical compounds proteins nucleic acids cellular membranes subcellular structures tissues organs visual elements interactively adjusted customized furthermore tool web server pathways pathway elements publicly accessible kind pathway crowd sourcing means pathwhiz already contains large rapidly growing collection previously drawn pathways pathway elements describe protocol quick easy creation new pathways alteration existing pathways facilitate pathway editing creation tool contains replication propagation functions replication function allows existing pathways used templates create edit new pathways propagation function allows one take existing pathway automatically propagate across different species pathways created tool styled different formats kegg like text book like colored different backgrounds exported biopax sbgn sbml pwml data exchange formats downloaded png svg images pathways easily incorporated online databases integrated presentations posters publications used exclusively online visualization exploration protocol successfully applied generate pathway diagrams found many online databases including hmdb drugbank smpdb ecmdb
paper relaxed micromorphic model proposed ghiba math mech solids neff contin mech thermodyn used study wave propagation unbounded continua microstructure studying dispersion relations considered relaxed medium able disclose precise frequency ranges band gaps propagation waves occur dispersion relations strongly nonlinear giving rise macroscopic dispersive behavior considered medium prove presence band gaps related unique elastic coefficient called cosserat couple modulus also responsible loss symmetry cauchy force stress tensor parameter seen trigger bifurcation phenomenon since fact slightly changing value around given threshold drastically changes observed response material respect wave propagation finally show band gaps accounted classical micromorphic models well cosserat second gradient ones potential fields application proposed relaxed model manifold concerns conception new engineering materials used vibration control stealth technology
objectives although guidelines recommend normalization platelet counts appropriate endpoint treatment high risk essential thrombocythemia retrospective studies could prove correlation diagnostic platelet counts increased thrombotic rate however increasing evidence leukocytosis important risk factor arterial thrombosis myeloproliferative neoplasms methods study considers austrian cohort european registry regarding platelet lowering therapeutic anagrelide influence platelet white blood cell wbc counts thrombotic risk assessed results using calculated cutoffs platelets wbc counts respectively cox regression analysis revealed clear influence elevated platelets wbc counts occurrence major thrombotic events time major thrombotic event shortest frequency related patient years highest platelet wbc counts ranged calculated cutoffs conclusion data add evidence impact platelet wbc counts thrombosis suspect particular interaction platelets wbc might based biological interplay depending particular cell counts
adsorption process found one oldest finest treatment methods surfactants removal control water pollution become important current years use physical chemical biological treatment methods membrane filtration ion exchange coagulation flocculation biological degradation become challenging terms cost efficiency adsorption technique extensively used surfactant removal present review focus made adsorption process using low cost materials compared techniques surfactant remediation
similarity differential equation beta beta considered differential equation appears study mixed convection boundary layer flows vertical surface embedded porous medium order prove existence solutions satisfying boundary conditions infinity use shooting consider initial value problem consisting differential equation initial conditions beta give partial results show differences previous case
prosocial media effects short long term intrapersonal changes prosocial personality traits values emotions behavior caused media use attracted much less attention media violence research empirical examinations current theories prosocial media effects focused indirect effects prosocial media explain exposure results prosocial behavior however neglected types media effects philosophical biases field communication social cultural perspective used explain psychological antecedents consequences prosocial media effects origins ultimate functions prosociality processes media effects unknown intersection evolutionary theories media effects theories provides comprehensive explanation prosocial media effects using various evolutionary perspectives altruism reciprocity cooperation article synthesizes types prosocial media effects selective indirect conditional transactional suggesting dramatic prosocial media learning process considered comprehensive nature nurture interactive view research agenda implications recent methodological advances highlighted
paper presents novel interleaved high conversion ratio bidirectional converter based switched capacitors coupled inductors series connected switched capacitor inductor cells used increase voltage conversion ratio reduce voltage stresses power switches realize soft charging discharging switched capacitors achieve autocurrent sharing parallel inductors interleaved structure combined switched capacitors adopted reduce current ripple side lower voltage thus enabling applications require high power levels paper first review status high voltage ratio bidirectional converters evolution proposed extensible topologies steady state operating principle inductor current continuous conduction mode presented finally performance features voltage gain voltage current stress autocurrent sharing mechanism realized switched capacitors verified optimal design coupled inductors switched capacitors chip size switches given specific design driving circuit facilitates actual applications described prototype converter employing hybrid configuration sic mosfets constructed verify theoretical analysis achieved optimal compromise conversion efficiency low cost
regardless service lifetime structure unwanted vibration occur due unknown sources excessive vibration may lead uncomfortable feeling occupant deterioration sensitive instruments industrial building determine nature mentioned vibration problems evaluation dynamic properties structure required recently researchers engineers spent lot effort control vibration behavior structures several methods developed field system identification alternative methods estimate structural modal parameters ssi arma paper discusses evaluation dynamic properties existing platform structures unwanted vibration appears material pumped pipe tends cause fatigue unwillingly dynamic evaluation performed obtain natural frequency structures using ssi arma model response measurement taken structure operational condition contribution mentioned models give satisfactory result compared fem model authors published elsevier ltd
aim authors randomized controlled study assess effect exercise nutrition education quality life early menopausal symptoms trial conducted east azerbaijan province iran period women allocated one four groups group block randomization interventions received three intervention groups nutrition education aerobic exercise exercise plus nutrition education control group receive intervention greene menqol menopause symptom scales completed weeks intervention mean greene score significantly lower control group exercise adjusted mean difference exercise plus nutrition groups end week nutrition exercise exercise plus nutrition groups end week also mean menqol score significantly lower control group exercise exercise plus nutrition groups end week nutrition exercise exercise plus nutrition groups end week nutrition education aerobic exercise improve quality life
evaluate visual quality visual secret sharing schemes existing metrics fail generate fair uniform quality scores tested reconstructed images propose new approach measure visual quality reconstructed image visual secret sharing schemes developed object detection method context secret sharing detecting outstanding local features global object contour quality metric constructed based object detection weight map effectiveness proposed quality metric demonstrated series experiments experimental results show quality metric based secret object detection outperforms existing metrics furthermore straightforward implement applied various applications performing security test visual secret sharing process
experimentally investigate suppression flutter long span suspension bridges rigid sectional model long span suspension bridge mounted wind tunnel suspension system control surfaces used suppress flutter movable flaps fitted bridge section leading trailing edges flaps responsive deck heave pitch motions paper aerodynamic force modeled using thin aerofoil theory although modeling techniques used controller second order passive transfer function inputs combination deck pitch angle heave position outputs flaps angular positions control system design problem solved infinity optimization problem
solar energy collection conversion great significance power transmission space solar power station ssps influences overall system technologically economically proposed ssps omega concept original conceptual design non uniform energy distribution excessive energy density local areas would cause decreases optical electric performance aiming point firstly paper evaluates optical performance omega concept via ray trace technique secondly generatrix geometry design photovoltaic cell array based bezier curve carried obtain optimal optical performance available efficient response sunrays numerical examples achieve good collection efficiency suitable energy distribution finally modular construction main concentrator influence optical performance investigated moreover effect orbital motion tracking error analyzed provide reference realization omega
constant interchain pressure idea addressed evaluate adequate quantitative assumption describe fluid mechanics oligomer diluted entangled nmmd polymer systems molecular stress function constitutive framework used constant interchain pressure assumption furthermore maximal extensibility based number kuhn steps entanglement used based relative pad inverse langevin function model predictions agree extensional measurements previously published poly methyl methacrylate almost published oligomer diluted nmmd polystyrenes deviation diluted largest molecular weight case mol polystyrene oligomer diluent case maximal extensibility needed
aimalthough female suicide rate japan one highest among oecd countries little done assess psychosocial psychiatric characteristics japanese female suicide completers study aimed examine sex differences psychosocial psychiatric characteristics suicide completers using psychological autopsy study method identify female suicide factors intervention points prevent female suicides methodsa semi structured interview conducted close family members adult suicide completers interview included questions regarding sociodemographic factors suicide characteristics previous suicidal behaviors family history suicidal behaviors financial problems physical psychiatric problems fisher exact test student test used explore sex differences survey items individual descriptive information female suicide cases also examined resultsof suicide completers female male females significantly higher prevalence history self harm suicide attempts prevalence eating disorders significantly higher among females males conclusionthe findings study highlight importance providing psychological social support caregivers repeatedly attempt suicide express suicidal thoughts suggest need improve community care systems aware suicide risk factors among female suicide attempters
background antifungal prophylaxis currently regarded gold standard situations allo genetic hematopoietic stem cell transplantation allo hsct however epidemiological information regarding prophylaxis invasive fungal diseases ifds clear china methods report first large scale patients observational study prophylaxis management ifds among patients allo hsct china results incidence rates ifd primary antifungal prophylaxis pap secondary antifungal prophylaxis sap non prophylaxis respectively median time transplantation ifd days pap patients days sap patients days non prophylaxis patients aspergillus spp represents common type fungal infection independent risk factors ifd allo hsct patients pap age human leukocyte antigen hla haploidentical matched unrelated donor decreased albumin levels use itraconazole prophylactic antifungal agent among sap transplant recipients significant risk factor ifds incidence rates overall survival pap sap prophylaxis groups respectively conclusions observational study indicates prophylaxis ifd helpful reduce incidence ifds improve patients allo hsct
planning adjusting one actions relation action partner fundamental smooth joint action first years life children gradually become engaged joint actions investigated whether age children take partner account action plans accommodate actions focused children proactive planning without prior experience flexible adjustment action plans time behavioural study tested children four age groups years joint cup stacking task children passed cups partner one hand available alternating time build tower children response choices assessed passing cup free occupied side partner study yielded two major findings ages children proactively planned actions way accommodated partner actions however years children start flexibly integrate partner action plans even age children showed minimal adjustments action partner candidate processes underlying developmental changes inhibitory control cognitive flexibility perspective taking discussed
density functional theory slab calculations performed investigate adsorption dissociation pure doped aim elucidate effect transition metal doping activation doping step edge found enhance binding initial state sequence improvement degree well adsorption final state contrast doping unfavorable analysis overall potential energy surfaces pes suggests dissociation facilitated doping kinetically thermodynamically wherein behave extraordinary interestingly substitute slightly superior kinetics whereas contrary case thermodynamics doping elevates energy height releases less heat relative manifesting negative effect besides classical bronsted evans polanyi relationship put forward another two neat linear relations well describe feature dissociation differences adsorption activation pure doped surfaces rationalized via electronic structure analysis findings presented herein expected provide theoretical guidance catalyst design optimization relevant processes elsevier rights reserved
architectural heterogeneity proven effective design paradigm cope ever increasing demand computational power within tight energy budgets virtually every computing domain programmable manycore accelerators currently widely used high performance computing systems also embedded devices operate coprocessors control general purpose cpu host processor clearly powerful hardware architectures paired sophisticated complex software ecosystems composed operating systems programming models plus associated runtime engines increasingly complex user applications related libraries system modeling always played key role early architectural exploration software development real hardware available necessity efficiently coping huge design space provided described heterogeneous systems chip socs calls advanced full system simulation methodologies tools capable assessing variousmetrics functional nonfunctional properties target system article describe virtualsoc simulation tool targeting full system simulation massively parallel heterogeneous socs also describe virtualsoc successfully adopted several research projects
anonymous questionnaire based survey used determine current practices opinions senior health professionals working western australian hospitals performing gynaecological procedures regarding routine use histopathology products conception poc obtained either surgical management miscarriage termination pregnancy sixty one senior health professionals completed survey tissue histopathology poc routinely requested miscarriage termination pregnancy top respondents respectively respondents listed main reasons requesting routine histopathology avoidance misdiagnosis medico legal quality assurance inconsistent practices among health professionals regarding sending poc histopathology gynaecology head departments recommend introduction state national guidelines use histopathology surgical management miscarriages terminations pregnancy
background primary healthcare services australia canada new zealand united states embraced concept family centred care promising approach supporting caring health young indigenous children families scoping review assesses quality evidence base identifies published literature family centred interventions indigenous early childhood wellbeing methods fourteen electronic databases grey literature sources reference lists indigenous maternal child health reviews searched identify relevant publications studies included intervention focussed indigenous children aged conception years abovementioned countries led primary healthcare service described evaluated scored greater validated scale family centredness study characteristics extracted quality rated reported aims strategies enablers outcomes family centredcare identified using grounded theory methods results eighteen studies reported publications included three randomised controlled studies qualitative exploratory design half publications published overarching aim interventions promote healthy families six key strategies support family behaviours self care increase maternal knowledge strengthen links clinic build indigenous workforce promote cultural community connectedness advocate social determinants health four enablers competent compassionate program deliverers flexibility access continuity integration healthcare culturally supportive care health outcomes reported indigenous children nutritional status emotional behavioural prevention injury illness parents caregivers depression substance abuse parenting knowledge confidence skills health services satisfaction access utilization cost community cultural revitalisation discussion conclusion evidence family centred interventions early stages development suggests promise generating diverse healthcare outcomes indigenous children parents caregivers well satisfaction utilisation healthcare community cultural revitalisation research pertaining role fathers family centred care effects costs interventions needed
backgroundscreening colorectal cancer crc successful decreasing incidence mortality crc although new screening tests become available relative impact crc outcomes remains unexplored study compares outcomes various screening strategies crc outcomes methodsa markov model representing natural history crc built validated empiric data screening trials well microstimulation screening analysis miscan model thirteen screening strategies based colonoscopy sigmoidoscopy computed tomographic colonography well fecal immunochemical occult blood stool dna testing compared screening simulated sample general population ages years average risk crc followed years death effectiveness measured discounted life years gained number crcs prevented discounted costs cost effectiveness ratios calculated discount rate used calculations study took societal perspective resultscolonoscopy emerged effective screening strategy highest life years gained life years crcs prevented lowest total costs values life years gained crcs prevented total cost respectively fobt life years gained crcs prevented total cost respectively dna testing improved sensitivity specificity screening test crc detection sufficient close outcomes gap compared colonoscopy conclusionsimprovement crc detection performance sufficient improve screening outcomes special attention must directed detecting precancerous adenomas cancer american cancer society colonoscopy remains effective screening tool colorectal cancer dna stool testing although interesting costlier effective colonoscopy effectiveness gap closed improving sensitivity specificity dna stool testing colorectal cancer
lighting systems consisting light emitting diodes leds excessive temperature amain cause degraded luminous efficacy leads reduced average illuminance distorted illumination rendering modeling thermal dynamics leds hence essential designing thermal dissipators controllers maintaining constant illuminance chromaticity existing literature physical modeling system identification proposed find dependence temperature input power power fluctuates due dimming control thermal dynamics becomes nonlinear moreover photoelectrothermal model used control synthesis nonlinearity due product temperature dependent efficacy input power must considered nonlinearities either ignored linearized existing methods main contribution work treating aforementioned nonlinearities linear parameter varying lpv framework first nonlinear thermal dynamics identified lpv system identification techniques controller track reference illuminance designed infinity control techniques robust temperature disturbance ambient light identification data designed controller collected verified real experimental setup
improvement expansion methods namely improved tan phi expansion method solving tzitzeica type nonlinear evolution equations proposed work dispersive optical solitons governed tzitzeica type nonlinear evolution equations result many new general exact travelling wave solutions obtained including periodic function solutions soliton like solutions trigonometric function solutions exact particular solutions containing four types hyperbolic function solution trigonometric function solution exponential solution rational solution obtained solutions comparing methods recently method developed searching exact travelling wave solutions nonlinear partial differential equations abundant exact travelling wave solutions including solitons kink periodic rational solutions found solutions might play important role engineering fields shown method help symbolic computation provides straightforward powerful mathematical tool solving nonlinear problems
objectives hypothesis number trained otolaryngologists available insufficient supply current projected health care needs goal study assess available databases present accurate data current otolaryngology workforce examine methods prediction future health care needs explore potential issues forecasting methods policy implementation based predictions study design retrospective analysis research databases public use files claims data methods total number otolaryngologists current practices united states tabulated using databases american academy otolaryngology head neck surgery american medical association american board otolaryngology american college surgeons association american medical colleges national center health statistics department health human services otolaryngologists identified surgeons classified surgical groups using combination ama primary secondary self reported specialties american board medical specialties certifications data gathered cross referenced rule duplications assess total practicing otolaryngologists data analyzed included type practice academic versus private general versus specialty demographics urban versus rural patient age reason visit referral new established surgical follow reason visit diagnosis payer type results analysis resources estimates total number otolaryngologists practicing united states approximately fully trained practicing physicians training residents fellows others based data workforce projections would place fully trained practicing otolaryngology workforce unless changes training occur aao hns physicians resource committee performed extensive analysis collated data multiple sources identified practicing otolaryngologists training estimated current attrition rate approximately otolaryngologists per year percentage distribution office visits patient age found years old reason visit new chronic chronic exacerbation pre postsurgical follow top diagnoses consisted otitis media chronic sinusitis impacted cerumen payer mix consisted private insurance medicare medicaid children health insurance program conclusions despite past findings predictions otolaryngologists practicing united states collated data resources places total fully trained practicing underestimation otolaryngology workforce impact future predictions resource utilization analysis even correction considered available trained otolaryngologists required serve otolaryngologic health care needs population still insufficient understaffed impact aging population estimated million newly insured citizens patient protection affordable care act also unprecedented variables must considered analysis differences physician productivity geographic population density model formation current otolaryngology workforce utilization needed predict future public health needs
background aims lateral spine radiographs provide inexpensive resource characterizing abdominal aortic calcification aac widely accepted measurement aac semi quantitative technique generated framingham heart study aac sought develop analytical method quantify acc aac lateral spine radiographs compare finding conventional subjective measurements methods severity aac quantified measuring pixel intensities user defined region aorta internal standardization vertebral endplates background calibration density vertebral body association bone mineral density bmd measured dual energy ray absorptiometry dxa aac measured aac aac modified framingham score aac determined participants canadian multicenter osteoporosis study camos results inter observer reliability aac slightly higher visual semi quantitative framingham method pseudo colored images illustrate potential meaningfully resolve severity calcification significant negative association aac bmd measures hip spine association remained significant adjustment age sex estimated glomerular filtration rate phosphate hypertension significant predictors acc included age hypertension conclusions aac reproducible approach measuring aac whether capable monitoring subtle calcific changes time requires study technique could applied large studies seek determine impact interventions modify bone density treatment vascular calcification cardiovascular disease general population published elsevier inc
scarcity fossil fuels affecting efficiency established modes cargo transport within transportation industry efforts made develop innovative modes transport adopted economic environmental friendly operating systems solid material instance packed rectangular containers commonly known capsules transported different concentrations effectively using fluid energy pipelines economical efficient design systems local flow characteristics global performance parameters need carefully investigated published literature severely limited establishing effects local flow features system characteristics hydraulic capsule pipelines hcps present study focuses using well validated computational fluid dynamics cfd tool numerically simulate solid liquid mixture flow shore shore hcps applications including bends discrete phase modelling dpm employed calculate velocity rectangular capsules numerical predictions used develop novel semi empirical prediction models pressure drop hcps embedded robust user friendly pipeline optimisation methodology based least cost principle elsevier ltd rights reserved
suicide important public health problem adolescents essential increase knowledge concerning etiology suicide among adolescent students therefore study designed examine associations hopelessness depression spirituality suicidal behavior examine spirituality moderator hopelessness depression suicidal behavior among malaysian adolescent students participants completed measures depression hopelessness daily spiritual experience suicidal behavior structural equation modeling indicated adolescent students high hopelessness depression also high spirituality less suicidal behavior others findings reinforce importance spirituality protective factor hopelessness depression suicidal behavior among malaysian adolescent students
present article investigate influence sociocultural stereotypes impression formation basketball players coaches experiment participants shown picture black white basketball player prior observation point light video player executing basketball free throw participant informed player depicted picture executing free throw results indicated ethnicity target player significantly influenced participant evaluations demonstrating specific stereotypes black white basketball players evaluating performance experiment results derived implicit association test indicated black players implicitly associated athletic player attributes results line social schema theory demonstrate similar findings reported united states subpopulation german basketball players coaches hold specific stereotypes abilities black white basketball athletes stereotypes bias impression formation coaches players make assessments basketball performance
conglomerate layer upper section member shahejie formation yongan district donying depression well developed sedimentation several periods lacks stable muddy layers sophisticated classification sedimentation periods proportion sedimentary layering period long difficult task geologists addressing problem paper attempts introduce theory climatic cycles driven astronomical periods astronomical stratigraphy basis characteristics sedimentation turbidity current region study studying conditions formation conglomerate layer factors control pinpoint formation layer chronology differentiate cycle interface correlation formation period milankovitch analysis conducted sedimentation conglomerate layer region study determine stratigraphy cycle region primarily controlled eccentricity cycle calculate msc msc thicknesses respectively milankovitch theory primary tool used analysis conjunction petrographic analysis stratum classified four grade sequences grade sequences information dominant cycle frequency used wave filtering well logs determine significant milankovitch wave log data curve may compare stratigraphy cycle characteristics standard cycle classify compare sedimentation periods conglomerate layers detail
oropharyngeal candidiasis common fungal infection hospitalized patients acquired immune deficiency syndrome aids progression results invasive infections significant cause morbidity mortality study aimed quickly accurately identify candida spp oral mucosa aids patients recruited presidente vargas hospital sao luis city brazil evaluate sensitivity profile fungi antifungals using automated system isolates collected oropharyngeal mucosa hospitalized aids patients anti viral antifungal therapies patients included research hiv positive years age obtaining written consent chromagar candida automatedvitek system used isolate identify candida spp respectively antifungal susceptibility testing performed using vitek system complemented etest using drugs amphotericin fluconazole flucytosine voriconazole oropharyngeal candidiasis high prevalence hospitalized aids patients prevalent species candida albicans antifungal susceptibility test showed candida spp susceptible dose dependent sensitive resistant candida krusei candida famata isolates two candida glabrata resistant fluconazole aids patients presented oropharyngeal candidiasis albicans frequently isolated species results showed high variability resistance among isolated species indicates need identify candida spp involved infection need test antifungal susceptibility guide drug therapy patients hospitalized aids first relate aids patients monitoring public hospital sao luis concerning precise identification establishing antifungal profile candida spp
real time accurate background modeling important researching topic fields remote monitoring video surveillance meanwhile effective foreground detection preliminary requirement decision making basis sustainable energy management especially smart meters environment monitoring results provide decision making basis energy saving strategies real time moving object detection video paper applies parallel computing technology develop feedback foreground background segmentation method parallel connected component labeling pccl algorithm background modeling method pixel wise color histograms graphics processing unit gpu memory generated sequential images pixel color current image locate around peaks histogram segmented foreground pixel foreground segmentation results pccl algorithm proposed cluster foreground pixels several groups order distinguish separate blobs noisy spot sparkle foreground segmentation results always contain small quantity pixels small blobs removed noise order refine segmentation results proposed gpu based image processing algorithms implemented using compute unified device architecture cuda toolkit testing results show significant enhancement speed accuracy
harnessing benefits cloud computing demands potential user adequate access trustworthy cloud services locating resources services heterogeneous network cloud environment may tedious task cloud computing form distributed system complex aggregation computing resources different domains different administrative policies immense benefits could enhance mode computing discovering cloud services complicated varied level quality service offered different providers hence monolithic approach cloud service discovery effectively support cloud environment work proposed distributive approach discovering trustworthy cloud services use multiagents system achieving intelligent cloud service discovery simulation experiments carried results showed extending multi agents system approach integrating trust process cloud service discovery improves quality service terms response time scalability comparative analysis multi agents system approach cloud service discovery monolithic approach showed highly efficient highly flexible trustworthy cloud service discovery
article detection missing hidden data processing well defined queries database discussed terms quality importance justified article also covers organization processing program implementation issues fuzzy queries database information systems authors published elsevier
manual handling municipal solid waste serious concern owing emerging occupational risks considering health risks municipal solid waste workers involved street sweeping waste collection waste processing rag picking assessed chandigarh india using interview schedule study tool result shows waste worker profession mainly dominated males except rag pickers lower literacy rate age distribution shows waste collectors rag pickers years age daily income waste workers ranges observed waste collectors street sweepers rag pickers use type protective gears owing casual attitude results various types injuries major occupational health issues reported various categories waste workers respiratory disorders injuries allergies prevalence respectively waste workers vulnerable occupational health hazards hence need safeguard formulation new laws policies
matrix computation considered core many machine learning graph algorithm workloads traditional single node age numerical analysis platforms like matlab provide matrix programming model natively data increasingly scaled big data era increasing demand seamlessly integrate large scale matrix computation distributed data parallel computing systems therefore variety matrix computation libraries implemented distributed computing platforms mpi hadoop spark however specific matrix based algorithm quite different performance different platforms challenging data scientists specify platform combination platforms given algorithm workflow achieve best performance solve problem paper put forward time cost based scheduling framework automatically specify best platforms matrix operations schedule execution workflow implemented system prototype using user language mpi spark backend computing platforms experimental results show time cost based model good accuracy less error rate average moreover scheduling framework built achieves efficient performance applications
new material clay developed resistance carbon dioxide flow upstream plugging storage wells thermogravimetric thermal stability material showed minimal variation weight loss incremental heating degrees adsorption desorption various modeled temperature showed exothermic spontaneous process maximum adsorption capacity obtained psi bar degrees higher pressure led storage capacity physisorption hysteresis curves freundlich bet models best fit equilibrium adsorption data average regression coefficient new material substitute conventional cement plugs upstream carbon sequestration prevents migration stored cement plug surface also developed new cement showed chemical interaction confirms economical impact using cement plug sequestrations wells elsevier rights reserved
paper aimed investigate influence online coding courses logical reasoning ability towards fifth sixth graders students used code org online programming courses three months raven standard progressive matrices testing understand change students logical reasoning ability experiment based technology acceptance model researcher edit code org learning attitude questionnaire explore attitude students towards courses factors influencing students learning online courses
objective study introduce intelligent learning software system aims improve students motivations academic achievements computer programming courses system based intelligent analysis approach formed via artificial neural network model trained cognitive development optimization algorithm intelligent approach tries provide appropriate materials students evaluating learning levels point types learning levels defined teachers associated specific abilities regarding computer programming determining learning levels according results performed activities possible software system provide appropriate materials applications corresponding types low learning levels thanks system possible learn abstract difficult computer programming based subjects easily order idea effectiveness system evaluated computer programming courses contribution students eventually positive results obtained several evaluation works
aim paper investigate possibility improving ride quality two axle railway vehicle single stage suspension means passive suspensions employing inerter device inerter mechanical one port element analogous capacitor electrical circuits goal improve ride quality vertical lateral motions response track irregularities performance benefits several simple passive suspension layouts demonstrated compared conventional scheme elastic effects damper inerter device taken consideration practical purposes optimum parameter values damper inerter parameters representing elastic effects provide guidance mechanical design purposes
epoxy silver nanowire agnw nanocomposites emerging class materials provide electrically conductive properties insulating epoxies adding agnws high aspect ratio however agnws easy agglomerate due van der waals attractions resulting obstacle enhance material properties silica nanoparticles snps known good affinity metallic nanofillers prevent agglomeration nanofillers study effect snps dispersion electrical properties epoxy agnw nanocomposites investigated nanocomposites agnw vol electrical conductivity sharply increased addition snps vol electrical network agnws could formed snp vol addition snp vol electrical percolation threshold epoxy agnw nanocomposites agnw vol electrical conductivity agnw vol high
integrity assurance configuration data significant impact microcontroller based systems reliability especially true running applications driven events behavior tightly coupled kind data work proposes new hybrid technique combines hardware software resources detecting recovering soft errors system configuration data approach based utilization common built microcontroller resource timer works jointly software based technique responsible periodically refresh configuration data experiments demonstrate non destructive single event effects effectively mitigated reduced overheads results show important increase fault coverage seus sets one order magnitude
work consider optical flow evolving riemannian manifolds parametrised sphere main motivation estimate cell motion time lapse volumetric microscopy images depicting fluorescently labelled cells live zebrafish embryo exploit fact recorded cells float surface embryo allow extraction image sequence together sphere like surface solve resulting variational problem means galerkin method based vector spherical harmonics present numerical results computed aforementioned microscopy data
background early diagnosis expeditious treatment newborns congenital hypothyroidism necessary avoid mental retardation methods survey practitioners southern conducted better understand common practices regarding neonatal findings compared current guidelines europe results responses indicated consensus thyroid hormone day appropriate dosage however despite guidelines advocating use practitioners reported commonly use imaging laboratory tests though experienced providers apparently used often conclusions together results show moderate adherence published guidelines treating diagnosing research needed determine providers deviate guidelines generalize results populations
blood marrow transplant clinical trials network bmt ctn protocol evaluated whether exercise stress management training hematopoietic cell transplantation hct improved physical mental functioning hct neither overall survival patient reported transplantation outcomes improved training intervention animal studies hct moderate intensity exercise weeks hct associated positive effects hematopoietic progenitors resulting improved donor engraftment improved survival accordingly performed secondary analysis data bmt ctn determine whether exercise engagement hct associated engraftment survival found significant associations self reported pre hct exercise levels engraftment survival also effect pretransplantation exercise either neutrophil platelet engraftment findings support observations animal models limited several shortcomings refute hypothesis exercise hct may beneficial american society blood marrow transplantation
background cognitive impairment common type diabetes mellitus strong association type diabetes alzheimer disease however know type diabetes patients dement biomarkers predict cognitive decline left ventricular hypertrophy lvh potentially marker lvh highly prevalent type diabetes strong independent predictor cardiovascular events date studies investigated association lvh cognitive decline type diabetes diabetes dementia study designed establish whether patients type diabetes lvh increased rates brain atrophy cognitive decline methods study single centre observational longitudinal case control study follow adult patients aged years type diabetes lvh case without lvh control assess change cardiovascular risk brain imaging neuropsychological testing two time points baseline months months primary outcome brain volume change months primary outcome presence cognitive decline months secondary outcome change left ventricular mass associated brain atrophy cognitive decline months discussion study test hypothesis patients type diabetes lvh exhibit greater brain atrophy without lvh understanding whether lvh contributes cognitive decline patients allow identify patients particular risk
internet things paradigm everyday objects equipped identifying sensing networking processing capabilities allow communicate one another devices services internet accomplish objective ultimately iot devices ubiquitous context aware enable ambient intelligence article reports current state research internet things examining literature identifying current trends describing challenges threaten iot diffusion presenting open research questions future directions compiling comprehensive reference list assist researchers
although trust fundamental social organizational functioning media often portray managers distrusting suggesting distrust others typical personality variable successful leaders study puts cliche distrustful manager test self report data behavioral data german socio economic panel refute cliche analyses reveal individuals managerial positions neither show lower level trust systematic reduction trust attaining positions moreover analyses demonstrate managers generally trusting non managers selection effect implies individuals trust others successful achieving managerial positions less trusting counterparts elsevier ltd rights reserved
serving vital role undergraduate curriculum capstone design courses face variety challenges challenges include lack student value utilization course objectives assessment tools sponsor retention funding issues large instructional demands many challenges may addressed placing larger genuine emphasis assessing product design project process design occurs oregon state university osu mechanical industrial manufacturing engineering capstone course currently organizes manages evaluates capstone projects using house quality hoq general hoq tool used relate project requirements design performance specifications additionally osu hoq serves contract students sponsors course instructors faculty advisers detailing exactly required design project guiding tool allow students self monitor progress throughout course iii objective means evaluating students performance terms product produced capstone design projects paper describes osu course introduces hoq presents time line implementation product assessment osu key changes shown move purely process based assessment framework current state total points design implementation term capstone course awarded based student design team accomplishing design product metrics per sponsor defined design requirements addition authors report course instructor perception regarding effect implementing hoq osu capstone course finally conclusions implications work presented
background purpose evidence effective treatment options orthostatic hypotension parkinson disease scarce elevation cholinergic tone pyridostigmine bromide reported way improve blood pressure regulation neurogenic hypotension without causing supine hypertension methods double centre double blind randomized active control crossover phase non inferiority trial pyridostigmine bromide clinicaltrials gov nct patients confirmed randomized days day pyridostigmine bromide day fludrocortisone crossover outcome measured peripheral central monitoring schellong manoeuvre questionnaires results thirteen participants enrolled april april nine participants completing trial arm repeated measures comparison showed significant improvement fludrocortisone primary outcome diastolic drop orthostatic challenge baseline pyridostigmine bromide fludrocortisone mmhg whilst pyridostigmine bromide effect fludrocortisone caused peripheral systolic supine rise baseline pyridostigmine bromide fludrocortisone mmhg central mean arterial supine rise baseline pyridostigmine bromide fludrocortisone mmhg subjective severity motor score quality life remained unchanged study interventions conclusions pyridostigmine bromide inferior fludrocortisone treatment trial provides first objective evidence efficacy day fludrocortisone causing minor peripheral central supine hypertension addition peripheral future trials include central measurements known correlate closely cardiovascular risk
background implant compounds undergo electrochemical process contact biological fluids well mechanical corrosion due abrasive wear production metal debris may inhibit repair processes none commonly used methods diagnose implant allergies used singly therefore panel tests performed allergic patients pre operative screening postoperative metal sensitisation suspected methods analysed patients painful prostheses subjects prone allergies using patch test comparison lymphocyte transformation test cytokine production evaluated identify prognostic markers early diagnosis aseptic loosening metal debris endocytosis cytoskeletal rearrangement visualised confocal microscopy results results demonstrate lymphocyte transformation test identify patients predisposition develop allergic reactions confirm diagnosis hypersensitivity patients painful prostheses prevalence cytokine pattern may used identify predisposition development allergic diseases selective presence osteoclastogenic cytokines may used predictor negative outcome patients painful prosthesis hypothesis prognostic value cytokines early markers aseptic loosening attractive confirmation would require extensive testing conclusions lymphocyte transformation test suitable method testing systemic allergies suggest combined use patch test lymphocyte transformation test associated cytokine detection selected patients could provide useful tool preventive evaluation immune reactivity patients undergoing primary joint replacement surgery clinical monitoring possible onset metal sensitization patients implanted devices
introduction article result research assessment torque power internal combustion engine using partial mixtures biodiesel masl meters sea level according norm sae inen rte conducted research group faculty motor vehicle engineering international university ecuador quito may july research concluded biodiesel behavior certain heights specifically masl using partial mixtures biodiesel colombian ecuadorian nationally produced biodiesel methodology comparative mathematical analysis described biofuel samples percentages furnished company lafabril taking account environmental factors native country tests conducted results data produced lab quantitatively substantiated partial mixtures biodiesel way obtained curvatures torque power well emission particulate matter discussion using characteristics local fuel respective partial mixtures biofuel decrease particulate matter efficient values torque power biofuel obtained last one stable regular since produce spikes obtained information
article first critically reviews major philosophical positions literature conscientious objection finds possess significant flaws substantial number problems stem fact views fail assess reasons offered medical professionals support objections observation used motivate reasonability view one part states practitioner lodges conscientious refusal must publicly state objection well reasoned basis objection subjected critical evaluation conscientious exemption granted reason giving requirement argued defenders philosophical views attempt avoid granting accommodation spurious objections based discrimination empirically mistaken beliefs unjustified biases implicitly committed reason giving requirement article concludes based considerations reason giving position reasonability view possesses decisive advantage debate
paper deals design evaluation quadratic optimal control method based bilinear state space modelling approach order improve asymptotic stability voltage source converter vsc steady state mathematical model vsc converter developed around operating point vsc converters increasingly popular development hvdc connection multi terminal grid mtdc main role studied vsc converter vsc hvdc transmission system regulate bus voltage intention paper propose rigorous control method based optimization algorithms finally proposed control method evaluated using matlab simulink
examined whether long syndrome lqts mutation carrier status symptomatic lqts associated depression whether sex differences potential relationships sample comprised participants men genetically defined lqts mutation carriers symptomatic asymptomatic control group consisted unaffected relatives depression assessed using beck depression inventory bdi association found lqts mutation carrier status depression multinomial logistic regression showed lqts mutation carrier men arrhythmic events scored higher depression compared control group even adjusting age beta blockers antidepressants social support binary logistic regression comparing symptomatic asymptomatic lqts mutation carriers showed symptomatic lqts associated depression men results unchanged additionally adjusted education findings suggest symptomatic lqts associated depression men women overall however depression frequent women men thus regular screening depression lqts mutation carriers unaffected family members important
use smarter temperature control technologies heating systems optimize use electric power performance piglets two control technologies resistive heating system assessed pig nursery pid proportional integral derivative controller thermostat systems evaluated regarding thermal environment piglet performance use electric power days heating system pid controller improved thermal environment conditions significantly efficient terms electricity use produce body weight kwh specific cost weight gain daily weight gain day feed conversion system thermostat kwh day respectively results indicate pid controlled heating system efficient electricity use provides better conditions thermal comfort animal performance heating thermostat
describe new reverse simulation approach analog mixed signal circuit test generation parallels digital test generation invert analog circuit signal flow graph reverse simulate good bad machine outputs obtain test waveforms component tolerances given circuit output tolerances specified functional test needs designer inverted graph allows backtracing justify analog outputs analog input sinusoids mixed signal circuits tested using approach present test generation results two mixed signal circuits four analog circuits one multiple input multiple output circuit analog backtrace method generate tests second order analog circuits certain non linear circuits handled existing methods lack fault model backtrace method proposed method also defines necessary tolerances circuit structural components order keep output circuit signal within envelope specified designer avoids problem overspecifying analog circuit component tolerances reduces cost prove parametric fault tests also detect catastrophic faults unlike prior methods structural rather functional analog test generation method
demand battery fed electrical vehicle bfev expected ascend rapid depletion earth petroleum resources range bfev still limited due limitation energy conversion efficiency energy recovery braking operation fast transient operation analysis improvement energy conversion system bfevs strongly recommended paper presents highly efficient electrical circuit bfevs combination controlled directional converter cuk converter first controlled isolated directional converter designed provide desired battery voltage motor control run flow power steady state transient conditions boost converter designed using one igbt one mosfet parallel condense conduction loss guarantee high output voltage comparative performance analysis cuk boost converter technique bfevs also presented equivalent matlab simulink simulation model system developed investigate performance electrical circuits different operating conditions cuk converter technique exhibits higher efficiency better performance compared proposed boost converter technique
objective authors compared cognitive behavioral therapy cbt psychodynamic therapy pdt treatment bulimia nervosa female adolescents method randomized controlled trial female adolescents partial according dsm received mean sessions manualized disorder oriented pdt cbt trained psychologists blinded treatment condition administered outcome measures baseline treatment end treatment months treatment primary outcome rate remission defined lack dsm diagnosis partial end therapy several secondary outcome measures evaluated results remission rates cbt pdt respectively significant differences odds ratio within group effect sizes cbt pdt significant improvements secondary outcome measures found cbt pdt improvements remained stable month follow groups small group effect sizes binge eating purging favor cbt eating concern favor pdt conclusion cbt pdt effective promoting recovery female adolescents rates remission therapies similar studies evaluating cbt trial identified differences small effects binge eating purging eating concern
reflecting nature skilled action easy fall familiar dichotomies one construes flexibility intelligence skill level intentional states characterizing automatic motor processes constitute motor skill execution learned fixed invariant bottom brute causal responses essay argue picture skilled automatic motor processes overly simplistic specifically argue adequate account learned motor routines constitute embodied skills given purely bottom brute causal fashion rather motor control intelligent way establish first review two recent accounts skill stanley krakauer front hum neurosci doi papineau inst philos suppl characterize automatic motor control responsible fine grained movements constitutive motor skill brute low level phenomena isolate five key features apply skilled motor control accounts correct together accounts posit motor control ballistic invariant independent general action trajectories insensitive semantic content independent personal level intentions final section paper appeal optimal control theory empirical evidence challenge commitment skilled action qualified features
objective determine associations maternal paternal psychiatric diagnoses tourette syndrome chronic tic disorder nationwide study method nested case control study linked data derived three national registers singletons born diagnosed finland january december identified matched four controls conditional logistic regression used examine associations parental psychopathology results altogether patients controls mother psychiatric diagnosis similarly father psychiatric diagnosis maternal paternal psychiatric diagnosis associated offspring odds ratio respectively association maternal psychiatric diagnosis stronger paternal psychiatric diagnosis maternal personality disorders anxiety disorders affective disorders psychotic disorders addiction disorders associated paternal ocd anxiety disorders associated conclusion parental psychiatric diagnoses especially mother associated diagnosed offspring studies required results generalized children associations maternal psychiatric disorders may reflect maternal specific environmental genetic influences
metaphor cultural trauma currently enjoys great popularity cultural literary studies combines two independent traditions trauma research writings cultural trauma based primarily philosophical reflections auschwitz limits representation emerged postwar writings members frankfurt school developed number poststructuralist thinkers addition proponents cultural trauma metaphor take advantage large body psychological psychotherapeutic studies experiences actual trauma victims including victims holocaust attempts integrate different research traditions concepts trauma ultimately successful writings cultural trauma display disconcerting lack historical moral precision aestheticizes violence conflates experiences victims perpetrators spectators traumatic events
children chromosome aberrations usually show developmental delays intellectual disability neurological disorders behaviour problems aim present study describe developmental trajectories communicative skills children chromosome aberrations considering possible relationships patterns language development children clinical characteristics intellectual disability autistic traits longitudinal data five children four linear deletions one ring syndrome followed years presented four five children showed profound intellectual disability three five showed autistic traits high individual variability found vocal gestural productions however modest increase children communicative symbolic skills detected time quality preverbal productions conclusion increase communicative skills children chromosome aberration slow need consider children characteristics terms type chromosome aberration level intellectual disability presence absence autistic traits predict possible linguistic outcomes give realistic expectation parents
study aimed assess using tree based models impact different dimensions religion risk factors suicide attempts islamic republic iran three hundred patients attempted suicide age sex matched patient attendants types disease referred kerman afzalipour hospital recruited study following convenience sampling religiosity assessed duke university religion index tree based model constructed using gini index homogeneity criterion complementary discrimination analysis also applied variables contributing construction tree stressful life events mental disorder family support religious belief strong religious belief protective factor low number stressful life events high mental disorder score formed two groups attempted suicide moreover high number stressful life events strong family support strong problem solving skills low mental disorder score less likely attempt suicide significance four variables ghq problem coping skills friend support neuroticism revealed discrimination analysis religious beliefs seem independent factor predict risk suicidal behavior based decision tree religious beliefs among people high number stressful life events might dissuading factor subjects need family support problem solving skills
activating janus kinase jak signal transducer activator transcription stat mutations discovered many cell malignancies including anaplastic lymphoma kinase alk anaplastic large cell lymphomas alcls however mutations occur minority patients investigate clinical application targeting jak alk alcl treated alk cell lines various histological origins jak inhibitors interestingly exogenous cytokine independent cell lines responded jak inhibition regardless jak mutation status jak inhibitor sensitivity correlated stat phosphorylation status tumor cells using retroviral shrna knockdown demonstrated jak inhibitor sensitive cells dependent jak stat survival jak stat gain function mutations found jak inhibitor sensitive cells moreover mutations alone explain jak stat dependency given wildtype jak stat sufficient promote cell survival cells either jakor stat mutations investigate whether mechanisms involved knocked upstream receptors gamma knockdown induced cell death selected jak inhibitor sensitive cells high expression levels cytokines including demonstrated cell lines well primary alk alcl tumors finally ruxolitinib jak inhibitor effective vivo xenograft alk alcl model data suggest cytokine receptor signaling required tumor cell survival diverse forms alk alcl even presence jak stat mutations therefore jak inhibitor therapy might benefit patients alk alcl phosphorylated stat
flipped classroom pedagogical model typical lecture homework elements course reversed teachers provide online materials students preparation lecture students dedicate practice course put practice flipped classroom computer programming courses teaching java languages since way utilizing learning system contents problem computer programming education although teachers explain grammar students create software well students give learning goal promote student learning motivation understanding computer programming training flipped classroom collaborative learning applied main feature approach spend time programming class collaboration among students order make practical software assign students homework using flash animations video data explaining lecture learning materials learn vocabularies grammar programming languages every week web based tests consisting easy questions confirm results homework every week done beginning actual classes useful clarify difficult parts understanding students notice additionally confirmed effectiveness approach comparing examination scores compared score average scores web based test written test mid exam became high minimum scores tests also became high standard deviation tests became low moreover student able make code console game collaborative learning
background study examined relationships watching wrestling television engaging health risk behaviors among older multi state sample adolescents methods random sample youth ages years communities states completed telephone surveys part national evaluation enforcing underage drinking laws program survey measured multiple health risk behaviors including substance use involvement date fighting violent behaviors sexual risk behaviors frequency watching wrestling two week period survey measured scale times multivariate analyses conducted logistic regression using generalized estimating equation gee model exchangeable correlation structure controlled within group clustering data presented adjusted odds ratios confidence intervals results males reported watching wrestling females adjusting ethnicity sex median family income age region country fighting behaviors family composition frequency watching wrestling associated tried hurt someone weapon engaging sexual intercourse without using birth control current cigarette smoker drinking frequency watching wrestling treated independent variable adjusting covariates additional time wrestling watched associated increased risk date fight threatening hurt someone weapon hurting someone weapon engaging sexual intercourse without using birth control example youth watched wrestling six times past two weeks likely engaged date fight adolescents watched wrestling conclusions frequently adolescents reported watching wrestling likely engage violent health risk behaviors
paper presents mathematical model proton exchange membrane fuel cells pemfcs taking account basic electrochemical equations including boost power converter approaching suitable design simulation power electronics systems embedded fcs power supplies simplified model uses kirchoff voltage law kvl applied conventional electric equivalent model pemfcs work fully implemented psim general mathematical model referred literature data including boost converter mostly used power interface fcs way model fully evaluated viewing interface power converter
background pregnant victims childhood maltreatment likely deliver preterm mechanisms explaining relationship unclear goal current pilot study investigate whether momentary stress cortisol serve mechanisms linking maltreatment history gestational length methods seventeen women enrolled study maltreated women completed two study sessions weeks gestation following session four times day two days women reported momentary stress levels text message provided corresponding salivary cortisol samples gestational length determined medical chart review results higher reports momentary stress associated shortened gestational length high stress predicted lower cortisol concentrations women maltreatment histories higher concentrations among women without maltreatment conclusion results pilot study provide preliminary evidence understanding mechanisms explaining increased risk preterm birth among childhood maltreatment victims
using developmental play assessment preliminary study described categories levels play objects produced young boys diagnoses full mutation fragile syndrome leading inherited cause intellectual disability additionally study examined concurrent associations child characteristics three different summary level variables representing object play skills presentation combinations recreating structured configurations objects highest play level emerging mastered participants number toys touched play sample index object interest positively related standardized measures receptive expressive language number different actions produced index play diversity negatively related autism symptom severity variables significantly related number nonverbal communication acts children produced interacting mothers play clinical implications future directions discussed learning outcomes readers able define framework categorizing developmental levels play discuss constructs represented three different summary level metrics play objects describe relationship object play skills child characteristics young males fxs elsevier inc rights reserved
prolonged hyperglycemia activates formation advanced glycation end products ages major dicarbonyl compounds methylglyoxal glyoxal found main precursors ages epsilon carboxymethyl lysine cml found predominantly higher diabetic population hypothesized phloretin apple gingerol ginger inhibit formation ages suppress receptor advanced glycation end products rage via nuclear factor erythroid related factor nrf dependent pathway phloretin gingerol supplemented two different doses cbl mice high fat diet standard diet period weeks phloretin gingerol supplementation significantly reduced plasma glucose alanine aminotransferase aspartate aminotransferase ages insulin levels phloretin gingerol also decreased levels ages cml levels via nrf pathway enhancing gsh gssg ratio heme oxygenase glyoxalase liver tissue results suggest phloretin gingerol potential dietary compounds alleviate diabetes induced complications elsevier ltd rights reserved
suffix array important indexing data structure biological sequence analysis increasing size genomic data necessitates use computer cluster speed computation paper compare performance two distributed suffix array construction algorithms run computer cluster first futamura aluru kurtz algorithm second kulla sanders performance two algorithms compared earlier due lack available software difficulty implementing paper answer still open question algorithm would better practice particularly genomic data implemented two algorithms made available comparison results show futamura aluru kurtz algorithm efficient practice despite fact algorithm kulla sanders better theoretical time complexity
lot work taken place design control converters various methodologies proposed traditionally controllers employed recent applications require fast transient performance impose usage derivative term well known using term cause numerous problems converters greatly downgrade performance lifetime said paper first prove using term possible increase stability margin hence keep low current ripple present novel method tune pid controller guarantees fast stable response wide range parameter values without using unreasonably high value derivative gain magnifies presence noise system controller designed utilising filippov method simple easy implement strategy proposed furthermore adaptive pid controller designed whose gains changed depending value supply voltage output load another important contribution work derivation saltation matrix switching manifold discontinuous complete proof presented results validated copyright john wiley sons ltd
political decision widen possibilities combing individual group psychotherapy could step promote group psychotherapy within health system view limited practical significance instead good evidence efficacy group treatments promotion would desirable paper summarized studies efficacy group psychotherapy general well compared individual psychotherapy limited evidence available related question combined treatments contrast one find wide variety clinical theoretical discussions literature certain circumstances recommend combined treatments related structural conditions political decision instead administrative barriers really lead increased use combined treatments accompanying research indispensable
present research aimed analyzing professional gestures museum educator specific situation demonstration foucault pendulum arts metiers museum paris professional gestures give ability present object mixed audience museum space open visitor circulation manage capture attention audience make scientific knowledge accessible educator work like teacher questions research team mind allowed conceive scientific museum educator action point view professional gestures
background psychiatric illness associated heightened hypothalamic pituitary adrenal hpa axis activity pregnancy may long term effects infant stress regulation hpa axis regulation previously investigated women eating disorders infants perinatal period methods women recruited prospective longitudinal study three groups current active past healthy control maternal psychopathology diurnal cortisol levels corticotropin releasing hormone crh crh binding protein crh measured third trimester pregnancy eight weeks postpartum infant cortisol obtained routine immunisations determine infant hormonal response stressful situation results women current significantly lower cortisol decline throughout day compared adjusted unadjusted analyses lower cortisol decline among women current associated higher levels psychopathology pregnancy women cortisol awakening response crh crh levels differ across three groups infants stress response also significantly higher among group although effect attenuated controlling confounders conclusions pregnancy women lower cortisol declines suggestive blunted diurnal cortisol rhythms postnatally infants also heightened response stress first study identify hpa axis dysfunction pregnancy women show intergenerational effect since dysfunctions hpa activity childhood may represent risk factor psychological physical health problems later life investigation potential long term implications findings crucial crown copyright published elsevier ltd rights reserved
recent embodiment research revealed cognitive processes influenced bodily cues cues found elicit disparate effects cognition instance weight sensations inhibit problem solving performance shown increase judgments regarding recall probability judgments learning jols memory tasks investigated effects physical effort learning metacognition conducting two studies varied whether backpackwas worn notwhile nouns learned participants entered jol word completed recall test experiment revealed exerting physical effort wearing backpack led higher jols easy nouns without notable effect difficult nouns participants wore backpack reached higher recall scores therefore physical effort may act form desirable difficulty learning experiment influence physical effort jols learning disappeared difficult nouns learned implying high cognitive load may diminish bodily effects findings suggest physical effort mainly influences superficial modes thought raise doubts concerning explanatory power metaphor centered accounts embodiment higher level cognition
need understanding generation employees attitudes expectations considerably differed previous generations focus researchers last decades industry specifically software industry among popular employment areas generation professionals hence generation software developers constitutes majority work force software industry known software development project based business project management methodologies principles utilized similar project based works effectiveness human resources management team development determinant project success software development therefore effectively manage adapt appropriate approaches leading project teams include generation software professionals managers leaders prior need understand perspective context research aims understand expectations attitudes generation software developer professionals projects research structured two parts reflecting dual aims first part research addresses expectations generation employees project management project environment software development projects second part research explores attitudes generation employees software development project teams survey conducted participation generation software professionals employed major software companies turkey basic concepts explored study expectations working environment expectations project type content leadership motivation factors challenges faced perceptions generation conflicts attitudes generation professionals towards project based work work environments software industry dominated project based management methods perceptions attitudes generation projects expected provide practical guidelines policy makers professionals developing solutions tools improving motivations effectiveness generation employees
paper provides empirical evidence regarding causal effects upgrading slum dwellings living conditions extremely poor particular study impact providing better houses situ slum dwellers salvador mexico uruguay experimentally evaluate impact housing project run ngo techo roof provides basic pre fabricated houses members extremely poor population groups latin america main objective program improve household well findings show better houses positive effect overall housing conditions general well members treated households happier quality life two countries also document improvements children health salvador slum dwellers received techo houses also feel safer find result however two experimental samples noticeable robust effects relation possession durable goods labor outcomes results robust terms internal external validity derived similar experiments three different latin american countries published elsevier inc
chaotic map complex dynamics ideal conditions however suffers problem performance degradation case finite computing precision order prevent dynamics degradation paper continuous chen chaotic system used perturb inputs parameters chebyshev map minimize chaotic degradation phenomenon finite precision experimental evaluations corresponding performance analysis demonstrate chebyshev chaotic map good randomness complex dynamic performance using proposed perturbation method attributes proposed system stronger original system chaos attractor approximate entropy finally corresponding pseudorandom number generator prng constructed method randomness evaluated via nist testu test suites respectively statistical test results show proposed prng high reliability randomness thus used cryptography potential applications
objective provide detailed picture economic impact hospitalization idiopathic pulmonary fibrosis ipf identify factors associated cost length stay los methods retrospective cross sectional study using nationwide inpatient sample nis study included hospitalizations ipf icd principal diagnosis respiratory disease icd lung transplant admissions excluded total inpatient cost los hospital death discharge disposition reported linear regression models used determine variables predictive los cost results non transplant ipf patients principal diagnosis respiratory disease admitted mean age female hospital patients received mechanical ventilation received non invasive ventilation mean los days overall mean admission cost hospitalized patients died transferred facilities routinely discharged adjusted los patients without mechanical ventilation days adjusted costs limitations positive predictive value algorithm used identify ipf optimal nis database follow patients longitudinally claims admission available claims indicate whether listed diagnoses present admission developed hospitalization exclusion transplant related expenditures lead estimation cost conclusion using nationally representative database found ipf respiratory related hospitalizations represent significant economic burden similar non transplant ipf admissions per year mean cost per admission mechanical ventilation associated statistically significant increases los cost therapeutic advances reduce rates costs ipf hospitalizations needed
munchausen syndrome proxy msbp also known fabricated induced illness child caretaker form abuse caregiver deliberately produces feigns illness person care proxy receive medical care gratifies caregiver affected children often hospitalized long periods endure repetitive painful expensive diagnostic attempts present analytically confirmed case msbp alimemazine year old boy brought repetitively pediatric emergency department mother presented limb tremors dysarthria obnubilation ataxia generalized tonic clonic seizures coinciding intermittent fever neither rest physical examination complementary tests showed significant alterations msbp suspected routine systematic toxicological analysis urine blood requested alimemazine detected biological samples administration drug never mentioned mother subsequent interview corroborated suspicion msbp clinically separation mother child neurological symptoms gradually improved complete disappearance cerebellar symptoms alimemazine quantified serum urine gastric content cerebrospinal fluid samples gas chromatography mass spectrometry maximum serum level hair quantification alimemazine performed ultra performance liquid chromatography tandem mass spectrometry different segments hair results confirmed regular substance use least eight last months hair starting proximal segment patient represents first case published analytical data alimemazine blood urine gastric content cerebrospinal fluid hair allowed prove acute repetitive poisoning alimemazine evidence msbp elsevier ireland ltd rights reserved
folktales serve descriptive well prescriptive role consistently depicting societal cultural norms sexist portrayals sanction marginality bukusu women particularly reflect prevailing gender roles expectations however contests identity representation ancient unwritten history analysis tales mothers hearths bukusu folktales proverbs offers wide range role models women depict female agency exacting circumstances florence mothers hearths bukusu folktales proverbs africa world pres red sea press females narrators protagonists primary audience act curator creators culture
background innate helper type immune responses mediated interleukin thymic stromal lymphopoietin tslp shown play important role pulmonary fibrosis animal models however clinical implications remain poorly understood methods tslp concentrations measured bronchoalveolar lavage fluids obtained normal controls ncs patients idiopathic pulmonary fibrosis ipf non specific interstitial pneumonia nsip hypersensitivity pneumonitis sarcoidosis results tslp levels significantly higher patients ipf relative ncs respectively nsip respectively respectively sarcoidosis groups respectively however levels significantly different ipf group receiver operating characteristic curves tslp levels revealed clear differences ipf groups auc respectively well ipf lung disease groups auc respectively cut values tslp shown differentiate ipf groups accuracy cut values tslp possessed accuracy differentiating among ipf interstitial lung disease groups conclusions innate immune responses may associated development ipf furthermore tslp levels bal fluids may useful differentiating ipf chronic interstitial lung diseases
energy saving hot topic due proliferation climate changes energy challenges globally however people perception using smart technology energy saving still concept stage means people talk environmental awareness readily yet reality accept pay given energy bill due availability electricity integral role modulating consumers attitudes towards energy savings challenge notably gap today smart technology design smart homes understanding consumers behaviour integration understanding smart technology part paris climate change agreement paramount singapore introduce smart technologies targeted reduce energy consumption paper focused perception singapore households smart technology usage save energy areas current research include energy consumption singapore households public programs policies energy savings use technology energy savings household perception energy savings smart homes furthermore three case studies reviewed relation smart homes smart technology discussing maturity existing solutions
parental health exposures affect lifetime health outcomes offspring independently inherited genotypes epigenetic effects occur broad range environmental stressors including defects parental metabolism although maternal metabolic effects well documented recently established also independent paternal contribution long term metabolic health paternal undernutrition overnutrition induce metabolic phenotypes immediate offspring cases induced phenotype affect multiple generations implying inheritance acquired trait male lineage transmission metabolic disease risk cases implicates heritable factor carried sperm sperm based transmission provides tractable system interrogate heritable epigenetic factors influencing metabolism detailed animal models paternal programming already provided significant insights review evidence paternal programming metabolism humans animal models available evidence potential underlying mechanisms programming paternal metabolism observed multiple species across animal phyla suggesting phenomenon may unique evolutionary significance
order obtain efficient phase change material pcm emerging montmorillonite stearic acid microcapsules containing core shell designed prepared via self assembly emulsion microcapsules coated hydrolysis polycondensation teos enhance structure stability microstructure thermal properties reliability microcapsules investigated via scanning electron microscopy sem differential scanning calorimetry dsc microcapsules presented sphere like particles size distribution freezing latent heat microcapsules degrees energy storage rate microcapsules faster compared microcapsules excellent structural stability high energy storage capacity stable energy storage release performances energy storage performances microcapsules superior composites prepared via vacuum impregnation excellent energy storage reliability capability microcapsules advantages solar energy storage fields elsevier rights reserved
monitoring deformation super tall structures different environmental conditions important challenging issue assessing safety serviceability structures paper presents new method calculating structural deformation using real time strain data easily measured different sections assuming structural deformation bending beam type deformation structure associated longitudinal strain virtual work theory used calculate horizontal displacement tilt angle building basis strain data different heights structure proposed method applied tall canton tower previously known guangzhou new tower long term structural health monitoring system including vibrating strain gauges installed different heights displacements tilts structure top normal typhoon conditions calculated using real time monitoring strain data calculated deformations show good agreement measurements using global positioning system gps inclinometers temperature induced maximum daily movement similar value typhoon induced motion moreover displacement mode super tall structure also calculated shows bending type error analysis demonstrates calculated displacements higher accuracy gps measured counterparts calculated tilts similar accuracy measured inclinometer elsevier ltd rights reserved
objective department hematology zealand university hospital denmark national institute public health university southern denmark created first nationwide population based comprehensive cross sectional health related quality life hrqol survey patients myeloproliferative neoplasms mpns denmark mpn patients treated public hospitals treatments received free charge patients therefore mpn patients receive best available treatment extent suitability wish receive treatment aims article describe survey design characteristics respondents nonrespondents material methods individuals mpn diagnoses registered danish national patient register npr invited participate registers danish civil registration system statistics denmark provided information regarding demographics survey contained questions validated patient reported outcome pro questionnaires additional questions addressing lifestyle results total individuals registered mpn diagnoses npr eligible participation responded overall respondents covered broad spectrum mpn patients patients years old living someone danish western ethnicity higher level education exhibited highest response rate conclusion nationwide population based comprehensive hrqol survey mpn patients denmark undertaken mpnhealthsurvey believe respondents broadly represent mpn population denmark however differences respondents nonrespondents taken consideration examining pros respondents results investigation respondents hrqol survey follow future articles
single nucleotide polymorphism snp ptpn protein tyrosine phosphatase nonreceptor leads arg trp polymorphism encoded human protein lyp allelic variant associated multiple autoimmune diseases including type diabetes crohn disease rheumatoid arthritis systemic lupus erythematosus however underlying mechanisms poorly understood study polymorphism influences immune system generated mouse strain knock trp allele imitating human disease associated variant find significant difference polymorphic wild type mice proportion total cell cell cell memory lymphocyte macrophage dendritic cells peripheral lymph nodes spleen however macrophages trp trp mice showed altered morphology enhanced function including higher expression mhcii molecules increased phagocytic ability leads higher cell activation specific antigen model shows alteration immune cell profile trp allele brings macrophages important player consider explaining ptpn trp allele effect autoimmune disease risk elsevier ltd rights reserved
complementation operation vertex digraph changes outgoing arcs non arcs outgoing non arcs arcs given digraph partially complemented digraph tilde digraph obtained performing sequence vertex complement operations dahlhaus showed given adjacency list representation tilde depth first search dfs performed tilde time tilde number vertices ill number edges tilde used finding depth first spanning forest strongly connected components complement time linear size dahlhaus give applications finding modular decomposition undirected graph require adjacency lists complemented others achieve bound algorithm makes use somewhat complicated stack like data structure simulate recursion stack instead implementing directly recursive algorithm give recursive tilde algorithm requires data structures elsevier rights reserved
although independent lines research identified misogynistic lyrical content traditional gender role beliefs reliable predictors men female directed aggression research needed understand extent variables may function synthesis potentiate aggression current study men completed questionnaires relevant conformity masculine norms level hostile benevolent sexism exposed either misogynistic neutral lyrics opportunity shock ostensible female confederate bogus reaction time task effect measured aggression results indicated misogynistic lyrics hostile sexism significantly predicted unprovoked provoked aggression female target contrary expectations moderating effects gender role beliefs relationship misogynistic lyrics men aggression found implications discussed terms costs misogyny media women lives wiley periodicals inc
decisions involving charitable giving often occur shadow risk common finding potential donors give less greater risk donation less impact behaviour could fully rationalized standard economic models article shows additional mechanism relevant use risk excuse give laboratory study participants evaluate risky payoffs risky payoffs charity decisions involve tradeoffs money charity respond similarly self risk charity risk contrast decisions force tradeoffs money charity participants act averse charity risk less averse self risk altered responses risk bias participants towards choosing payoffs often consistent excuse driven responses risk additional results support existence excuse driven types
introduction development personality disorders well sexual disorders defined common time spectrum well deficits changes areas biological environmental mental area dissocial antisocial personality disorder characterised pervasive pattern disregard violation rights others indices discussed disorder found specific patterns social inadequacy occurring childhood puberty time characteristic indices social functioning young age often indicate subsequent dysfunctions area sexuality aim aim paper explain sexual functioning persons dissocial personality disorder including relation sexual dysfunctions ascertain issues need empirical studies method result analysis available literature matched ebsco database search fulfilling criteria sample size accuracy examination procedure conclusions discussion articles fulfilling criteria cited found conclusions based literature overview appeared impossible determine one coherent way sexual functioning dissocial persons establish causal relationship sexual dysfunctions dissocial personality disorder however possible indicate group characteristic dysfunctional sexual behaviours noteworthy available publications analyse selected aspects sexual behaviours small homogenous groups lack review studies well multi faceted studies
article details preliminary findings porn laid bare collaborative research project university sussex terrence higgins trust brighton explore multidimensional relationship respondents identified formed pornographic material together role within gay male subculture consider interview respondents understood conceptualised bareback pornography findings reveal consistent contradictions general discussions gay pornography specific discussions bareback representations utilising dean work bareback subculture ambivalent gift develop critical reading contradictions order identify methods anxieties pleasures bareback pornography handled respondents
maintenance gut health complex relies delicate balance diet commensal microflora mucosa including digestive epithelium overlying mucus layer superimposed balance frequent presence enteric bacteria pathogenic potential proliferation metabolic activity may perturb digestive function lead diarrhoea poor growth rates even death enteric infections pathogenic bacteria common young animals children diet important influence gut health including effects proliferation pathogenic bacteria provide either beneficial harmful input dietary fibre dietary component major influence regard heterogeneous class components hydrolysed digestive enzymes non ruminant animals consequently main substrates bacterial fermentation distal part gut review presents evidence components dietary fibre may improve gut health alternatively enhance gut perturbation subsequent diarrhoea young animals including piglets chickens children review reports discusses interacts gut epithelium mucus directly way microflora consequently protect enhance enteric infections elsevier science rights reserved
religious accommodation workplace remains contentious issue united states conducted experiment examine individual differences right wing authoritarianism rwa shape people react religious accommodation requests muslim versus christian employees results reveal participants exhibited bias toward employees requesting religious accommodations compared employees requesting secular accommodations rwa determined religion stigmatized raters high rwa stigmatized muslims heavily requesting religious accommodations raters low rwa stigmatized christians heavily request results consistent ideologically objectionable premise model iopm prejudice demonstrating high low rwa exhibit symmetrical biases toward religious practices aligned values discuss implications findings future scholarship authoritarian traits elsevier ltd rights reserved
nitrate water pollution mainly causedby agricultural activities remains international problem cause serious long term environmental human health issues due nitrate time lag groundwater system however nitrate subsurface legacy issue rarely considered environmental water management developed simple catchment scale approach investigate impact historical nitrate loading agricultural land nitrate concentration trends sandstones represent major aquifers eden valley model developed considers spatio temporal nitrate loading low permeability superficial deposits dual porosity unsaturated zones nitrate dilution aquifers monte carlo simulations undertaken analyse parameter sensitivity calibrate model using observed datasets time series annual average nitrate concentrations generated four aquifer zones study area results show nitrate concentrations bees sandstones silicified penrith sandstones non silicified penrith sandstones keep rising stay high declining stable levels whilst inter bedded brockram penrith sandstones level slight decrease study help policymakers better understand local nitrate legacy issues also provides framework informing long term impact timescale different scenarios introduced deliver water quality compliance model requires relatively modest parameterisation readily transferable areas authors published elsevier
addiction pathology progressively insidiously undermines one autonomy manifested among ways experience sense alienation oneself others therefore seeking overcome addiction rehabilitative journey must facilitate fostering autonomy much autonomy socially embedded capacity must therapeutic process within context client counselor relationship grounded attentiveness facilitation autonomy dialogical antecedents one means achieving counselor attending expressing presence engaged person person therapeutic alliance underpinned collaborative dynamic healthy interpersonal dyad client counselor provide environment client may fully recognize autonomous resources exercise resources way enables embark rehabilitative journey attendant autonomous living
synchrophasor data start play significant role power system operation dynamic study data processing data analysis capability critical wide area measurement systems wamss frequency monitoring network fnet grideye wams network collects data hundreds frequency disturbance recorders distribution level previous fnet grideye data center limited data storage capability computation power targeting scalability extensibility concurrency robustness distributed data analytics platform proposed paper process large volume high velocity dataset variety real time non realtime synchrophasor data analytics applications hosted platform computation load shared balance multiple nodes analytics cluster big data analytics tools apache spark adopted manage large volume data boost data processing speed future data analytics applications easily developed plugged system simple configuration
developed array transducer integrated transmit receive application specific integrated circuit asic real time intracardiac echocardiography ice applications asic transducer design optimized high voltage transmit low voltage time gain control preamp subaperture beamformer digital control circuits transducer element fit within area element transducer assembly deployed diameter catheter integrated vivid ultrasound imaging system evaluated three preclinical studies image quality imaging modes comparable commercial ice catheters field view least degrees degrees could imaged vol sufficient visualize cardiac anatomy diagnostic therapy catheters ice significantly reduce ray fluoroscopy use dose electrophysiology ablation procedures ice may able replace transesophageal echocardiography tee associated risks costs general anesthesia guidance structural heart procedures
engineering quality important development economy project construction increasing appearance jerry built project causes significant financial losses country imposes threats safety life property meanwhile quality engineering springs quality taken account article described constructing process baoji high tech sewage conduit construction engineering construction technology measures key point process illustrates construction details
study provides evaluation group schema therapy inpatient treatment patients personality pathology respond previous psychotherapeutic interventions forty two patients assessed pre posttreatment patients evaluated follow months later results showed dropout rate dropped differ completed treatment regard demographic clinical variables exception dropped showed lower prevalence mood disorders furthermore intention treat analyses showed significant improvement maladaptive schemas schema modes maladaptive coping styles mental well psychological distress treatment improvements maintained follow hand significant change experienced parenting style self reported patients changes schemas schema modes measured pre posttreatment predictive general psychological distress follow overall preliminary findings suggest positive treatment results obtained group based inpatient treatment patients respond previous psychotherapeutic interventions moreover findings comparable treatment results patients without nonresponsive treatment history
aiming difficult problem high precision frequency stabilization semiconductor laser diode laser frequency control realized design semiconductor drive system relationship emission frequency temperature derived theoretically temperature corresponding stable frequency obtained according desired temperature stability temperature control system designed composed temperature setting circuit temperature gathering circuit temperature display circuit analog pid control circuit semiconductor refrigerator control circuit module sampling technology voltage platinum resistance acquired converted temperature display liquid crystal display pid analog control circuit controls speed stability precision temperature control constant current source circuit designed provide reference voltage voltage stabilizing chip buffered operational amplifier connected mosfet drive semiconductor laser provide stable current semiconductor laser pcb circuit board finished experimental justified experimental results show design temperature control system could achieve goal temperature monitoring meanwhile temperature stabilized degrees degrees output voltage constant current source current
rapid increase information accessibility recent years activated paradigm shift algorithm design artificial intelligence recently deep learning surrogate machine learning several contests pattern recognition machine learning review comprehensively summarises relevant studies much prior state art techniques paper also discusses motivations principles regarding learning algorithms deep architectures
infrared radiation intensity generally used embody stealth characteristics supersonic aircraft directly affects survivability warfare circumstances research signature important branch stealth technology significant overcome threat survivability enhancement considering existence uncertainties material environment intensity indeed range rather specific value paper subjected properties analytic process containing uncertainty propagation reliability evaluation investigated taking account temperature object atmospheric transmittance spectral emissivity materials regarded uncertain parameters one thing vertex method used analyze estimate dispersion intensity another safety assessment stealth performance aircraft conducted non probabilistic reliability analysis purpose comparison verification monte carlo simulation discussed well validity usage efficiency developed methodology demonstrated two application examples eventually elsevier rights reserved
background evidence burden depression internet addiction poor sleep quality undergraduate students nepal virtually non existent interaction sleep quality internet addiction depressive symptoms frequently assessed studies well explored sleep quality internet addiction statistically mediates association two variables methods enrolled students undergraduate campuses chitwan kathmandu nepal assessed sleep quality internet addiction depressive symptoms students using pittsburgh sleep quality index young internet addiction test patient health questionnaire respectively included responses students data analysis removing questionnaires five percent fields missing via bootstrap approach assessed mediating role internet addiction association sleep quality depressive symptoms sleep quality association internet addiction depressive symptoms results overall students scored validated cutoff scores poor sleep quality internet addiction depression respectively poorer sleep quality associated lower age alcohol user hindu sexually active failed previous year board examination higher internet addiction associated lower age sexually inactive failed previous year board examination depressive symptoms higher students higher age sexually inactive failed previous year board examination lower years study internet addiction statistically mediated indirect effect sleep quality depressive symptoms sleep quality hand statistically mediated indirect effect internet addiction depressive symptoms conclusions current study great proportion students met criteria poor sleep quality internet addiction depression internet addiction sleep quality mediated significant proportion indirect effect depressive symptoms however cross sectional nature study limits causal interpretation findings future longitudinal study measurement internet addiction sleep quality precedes depressive symptoms necessary build upon understanding development depressive symptoms students
several studies sustainable technologies built environment green roofs green walls etc carried many focus technical performance technologies nonetheless also becomes necessary examine public perceives technologies understanding clearly important support widespread use specifically perception incorporated product design increase people acceptance contribution paper twofold first presents results survey examining perception people small city southern region brazil feliz regarding three sustainable technologies green roofs green walls composting dry toilets second proposes set preliminary design guidelines improve acceptance sustainable technologies based people perception make technology look good make visible benefits provided technology design technology avoid misunderstandings concerns american society civil engineers
programmable logic controllers plc technology programming languages communication capabilities advanced plcs offer many control devices attached directly plc reason plc education became important issue many interdisciplinary engineering departments universities paper automation set laboratory plc developed operated various ways programming plc desired designed set also enables students understand operation principle elevator developed educational laboratory set used practice sensors actuators control systems industrial automation courses laboratory tool also provides method improve learning outcomes skills real time experiences engineering education electrical electronics mechatronics control engineering
use high resolution ground based light detection ranging lidar datasets provides spatial density vertical precision obtaining highly accurate digital surface models dsms result reliability flood damage analysis improved significantly owing increased accuracy hydrodynamic models addition considerable error reduction achieved estimation first floor elevation critical parameter determining structural content damages buildings however discrete measurement technique lidar data contain object space ambiguities especially urban areas presence buildings floodplain gives rise highly complex landscape largely corrected using ancillary information based addition breaklines triangulated irregular network tin present study provides methodological approach assessing uncertainty regarding first floor elevation based generation urban tin lidar data density points complemented river bathymetry obtained field survey density points tin subsequently improved adding breaklines finally transformed raster spatial resolution implementation two dimensional hydrodynamic model based year flood return period high resolution dsm obtained previous step facilitated addressing modelling since represented suitable urban features influencing hydraulics streets buildings iii determination first floor elevation uncertainty within year flood zone performing monte carlo simulations based geostatistics control elevation points order assess error deviations first floor elevation average standard deviation show parameter neatly characterized order obtain reliable assessments flood damage assessments implement realistic risk management
paper studies dynamic performance electric machine integrated transrotary magnetic gear mitromag motoring mode operation mitromag formed mechanically coupling rotary electric machine rotor trans rotary magnetic gear tromag tromag magnetic device magnetic fields converts low torque high speed rotation rotor high force low speed linear motion translator vice versa motoring mode operation rotor tromag driven rotary electric motor result translator drives reciprocating load nonlinear dynamic model developed tromag oscillation tests presented examples model used predict dynamic behavior device model linearized derive system transfer functions study dynamic response mitromag speed commands experimental results confirm analysis
military heterogeneous wireless sensor network mhtwsn emerging technology due extending services mhtwsn becoming widely preferable network border area monitoring enemy object tracking sensitive unmanned areas however security one key challenging issue mhtwsn many routing protocols like aodv aomdv imr imcc proposed efficient routing establishment data delivery routing protocols results poor performance network security attack proposed new secure multipath routing protocol nsrp military heterogeneous wireless sensor network mhtwsn secure data transmission nsrp uses elliptic curve cryptography ecc discover trusted neighbor nodes establish secure multiple routes reliable data delivery mhtwsn protocol efficient key management mechanism provides better security improves network performance nsrp achieved low communication overhead memory requirement energy consumption compared existing key management schemes
fifty years research effect violence children leads inescapable conclusion viewing media violence related increases aggressive attitudes values behaviors changes aggression short term long term changes may mediated neurological changes young viewer effects media violence real strong confirmed careful reviews research evidence various scientific professional organizations concerned children mental health development
transient operations crucial high power insulated gate bipolar transistor modules high current voltage applied period several microseconds therefore ability doubly fed induction generator dfig variable speed wind turbine power converters withstand abnormal conditions strictly imperative order achieve lifetime specifications also fulfil grid codes study presents new control scheme dfig wind turbine parallel interleaved converters pic configuration series dynamic braking resistor sdbr connected stator side interleaving wind turbine converters parallel configuration could help increase current capability sdbr helps post fault recovery wind turbine coordinated control analysis scheme implemented power system computer aided design electromagnetic transient including simulation environment severe three phase ground fault results obtained compared conventional chopper crowbar rotor circuit protection scheme wind turbine better performance wind turbine variables achieved using proposed control scheme pic sdbr space vector modulation pic results maximum value change common mode voltage leading improved switched output voltage voltage source converter leg
indications anticoagulation thromboembolic events prosthetic heart valves atrial fibrillation corresponding risk score clinical trials excluded patients advanced chronic kidney disease data always generalized patients chronic kidney disease non vitamin antagonist oral anticoagulants noacs mostly recommended contraindicated advanced stages chronic kidney disease observational studies shown dialysis patients atrial fibrillation profit coumarin anticoagulants prospective studies lacking
evaluate lung function responses short term indoor concentrations conducted panel study healthy schoolchildren aged years following lung function parameters fvc fev pef mid expiratory flows mef mef mef measured schoolchildren secondary school wroclaw poland years days spirometry tests conducted simultaneously samples collected inside school premises information differentiating factors children including smoking parents sex living close busy streets dust mold pollen allergies collected means questionnaires account repeated measurements method generalized estimating equations gee used gee models entire group children revealed adverse effects small differences effects estimates per interquartile range iqr mef mef mef fev imply likely component might principal health effect lung function parameters however reduction fvc pef per iqr respectively higher respectively adjustment potential confounders change unadjusted analysis
background previous studies demonstrated post weaning social isolation iso mice induces behavior abnormalities deficits sociability attention like behaviors deficits attenuated methylphenidate mph drug used attention deficit hyperactivity disorder adhd suggesting iso mice offer potential animal model comorbid developmental disorder adhd autism spectrum disorder symptoms study investigated effects kampo formulae yokukansan yks keishito kst neuropsychiatric symptoms iso mice clarify therapeutic preventive delaying potential formulae treatment neurodevelopmental disorders methods three week old male icr mice socially isolated experimental period yks kst administered starting week week starting iso analysis therapeutic preventive delaying potentials respectively sociability attention related behavior fear memory elucidated chamber test water finding test fear conditioning test respectively moreover phosphorylation neuroplasticity related signaling molecules mice hippocampus analyzed using western blotting results therapeutic procedure yks ameliorated iso induced impairments attention like behavior context dependent fear memory sociability whereas kst beneficial effects iso mice experiments analyze preventive delaying potentials treatments yks kst improved sociability attention context dependent fear memory deficits improvement sociability mice yks kst inhibited dopamine receptor antagonist suggesting yks kst improved iso induced sociability deficit mechanisms besides activation dopaminergic system hand beneficial effects yks kst attention like behavior inhibited muscarinic antagonist suggesting yks kst ameliorated iso induced attention like behavior cholinergic mechanism moreover phosphorylated forms camkii creb regulated iso stress restored yks kst administration conclusions findings suggest yks kst may useful improvement neurodevelopmental disorders
much focus sexual health people living hiv promoting safe sex behaviours however also important sexual health positive sexual self esteem article reports interpretative phenomenological analysis interviews seven men impact hiv sense sexual self five overarching themes identified destruction sexual self feeling sexually hazardous sexual inhibition reclaiming sexual self finding place sero sorting hiv chronic illness interventions required support people lead sexually satisfying lives
reversibility failure detection localization capabilities sensors based graphene nanoplatelets gnps tested results shown strain sensing capability reversible presenting hysteresis demonstrated endure cycles elucidated stationary load applied normalized electrical resistance increases remains mainly constant load maintained load completely removed structure recovers initial electrical resistance reinforced reversibility sensor additionally developed gnp epoxy sensors demonstrated detect locate damage sample due breakage electrical network failure occurs could differentiated changes due strain caused abrupt increase elsevier ltd rights reserved
industry offers vast armamentarium skin care products clean soothe restore reinforce protect treat skin hence keep good condition skin care products readily available promotions fanciful claims omnipresent promotions based effects evoked actives delivered vehicles rely specific technologies due fact products direct contact target tissue vehicle ingredients able profoundly modulate characteristics skin functions makes products skin absolute unique versatile delivery systems paper discusses concept skin care skin protection choice skin care products vehicles functionality regulatory status tissue viability society published elsevier ltd rights reserved
background diseases often carry cultural meanings metaphors meanings influence illness experiences behavioral responses objectives research investigated old cultural stereotypes new social understandings overactive bladder oab intertwined influence sick role adaptation behavioral responses among oab methods qualitative approach using depth individual semistructured interviews adopted thirty patients oab purposively sampled patient self help group people oab results cultural stereotypes oabas old people disease hopeless disease without cure sexually related disease disease substance usehad significant impact social illness experiences participants leading difficulty adapting sick role indicated behavioral responses denial concealment resignation self seclusion discussion cultural stereotypes oab significantly influenced sick role adaptation affected illness experiences persons oab cultural stereotypes associated behavioral responses led difficulties coping oab
examine impact programs led community health workers health function older adults arthritis health conditions conducted cluster randomized trial arthritis foundation exercise program afep enhanced keys healthy aging compared afep program sites participants mean age years women white trained community health workers delivered week programs outcomes assessed months included physical performance short physical performance battery sppb western ontario mcmaster universities womac osteoarthritis index preventive health behaviors groups experienced improvements performance improved sppb points afep keys group afep alone womac scores declined points respectively participants controlled hypertension months groups baseline afep keys afep alone greater diabetes control respectively community based programs showed similar improvements preventive health mobility arthritis outcomes
progress research health behavior change accelerated experimental medicine offers approach help investigators specify research questions need addressed evidence needed test questions whereas current research draws predominantly multiple overlapping theories resting largely correlational evidence approach emphasizes experimental tests targets mechanisms change programmatic research targets change health behaviors techniques change targets evidence engaging particular targets promotes behavior change however systematic studies needed identify validate targets discover targets best engaged approach promises progress answering key question enable science health behavior change improve public health strategies effective promoting behavior change circumstances
optical receivers used wdm networks often preceeded optical amplifier ensure good receiver sensitivity letter present experimental investigation homowavelength crosstalk optically preamplified systems using transmission scheme light source dfb laser modulated either directly externally electrical generator performance comparisons modulation schemes given show influences noise contribution amplified spontaneous emission ase noise john wiley sons inc
field observations downslope bentonite erosion geosynthetic clay liner gcl covered black geomembrane reported composite liner left exposed without protective soil cover much longer recommended gcl manufacturer new nondestructive light transmission technique developed investigate bentonite erosion features field presented classification system developed describe type erosion features observed results five field investigations queen university environmental liner test site quelts reported quantify onset progression severity downslope erosion one particular geotextile encased needle punched gcl exposure periods weeks years first significant erosion feature type bentonite loss narrower observed months exposure irrecoverable erosion features type bentonite loss wider observed months exposure findings highlight need follow manufacturer recommendations timely covering composite liner soil following liner installation
previous studies shown bone marrow micro environment supports myeloproliferative neoplasms mpn phenotype including via production cytokines induce resistance frontline mpn therapies however mechanisms occurs poorly understood moreover ability rapidly identify drug agents act adjuvants existing mpn frontline therapies virtually non existent using novel predictive simulation approach sought determine effect various drug agents mpn cell lines without micro environment derived inflammatory cytokines first created individual simulation models two representative mpn cell lines hel set based genomic mutation copy number variation cnv data running computational simulations virtual cell line models identified synergistic effect two drug agents cell proliferation viability namely jak kinase inhibitor bcl inhibitor abt show impact cells due predicted lack signaling within cells interestingly tnf alpha increased sensitivity single drug agents use combination ifn gamma decreased sensitivity summary study predictively identified two drug agents reduce mpn cell viability via independent mechanisms prospectively validated moreover efficacy either potentiated inhibited micro environment derived cytokines lastly study validated use simulation based technology prospectively determine responses
circulating tumor dna analysis emerged potential noninvasive alternative tissue biopsies tumor genotyping patients metastatic cancer particularly attractive cases tissue biopsies contraindicated repeat genotyping progression treatment required however tissue plasma analysis results always concordant clinical interpretation discordant results completely understood discordant results could arise due analytical limits assays used tumor plasma dna analysis due low overall contribution tumor specific dna plasma factors ruled tissue plasma concordance quantitative levels somatic mutations plasma capture tumor heterogeneity longitudinal follow patients feature leveraged track subclonal evolution guide combination sequential adaptive treatment summarize recent results evaluating opportunities limitations circulating tumor dna analysis context tumor heterogeneity subclonal evolution patients advanced cancers elsevier inc rights reserved
distributed version control systems vcss git mercurial hosting services github bitbucket revolutionalized way developers collaborate allowing freely exchange integrate code changes peer peer fashion however flexibility comes price code changes hard track proliferation code repositories developers modify rebase filter cherry pick history changes streamline integration repositories developers consequence researchers practitioners typically consider cleaned history official project repository unaware important elements activities collaborative software development process paper present method continuously mines known vcss software project uncover complete development history project use method show divergence code development history official linux kernel repository complete kernel development history investigate characteristics ecosystem git repositories linux kernel finally discuss continuous mining could adopted current vcs hosting services
myeloperoxidase mpo leukocyte derived enzyme mainly secreted activated neutrophils known involved immune response bacterial fungal infection inflammatory diseases nevertheless role mpo parasitic disease like malaria unknown hypothesized mpo contributes parasite clearance address hypothesis used plasmodium yoelii nonlethal infection wild type mpo deficient mice murine malaria model detected high mpo plasma levels wild type mice plasmodium yoelii infection unexpectedly infected mpo deficient mice show increased parasite loads able clear infection rapidly wild type mice additionally presence neutrophils onset infection seemed essential control parasitemia effect decreased parasite levels mpo deficient mice absent animals lacking mature cells indicating effect likely dependent adaptive immune response mechanisms indeed observed increased gamma interferon tumor necrosis factor alpha production cells infected mpo deficient mice together results suggest mpo modulates adaptive immune response malaria infection leading attenuated parasite clearance
paper presents direct measurement cylinder friction single cylinder motocross race engine motored conditions compares new analytical predictive method conditions encountered piston cylinder system application cylinder deactivation cda technology growing trend analytical method takes account various regions within instantaneous contact compression ring cylinder liner including lubricant film rupture cavitation zone subsequent lubricant film reformation analysis also includes effect boundary friction lubricant rheology predictions direct measurements cyclic friction show good agreement indicate dominance viscous friction investigated engine running conditions particular shown compression ring contribution cycle friction pronounced region high cylinder pressures combined poiseuille friction boundary solid interactions combined experimental analytical approach hitherto reported literature
machine learning algorithms applied text categorization mostly employ bag words bow representation describe content documents method successfully used many applications known several limitations one way improving text representation usage wikipedia lexical knowledge base approach already shown promising results many research studies paper propose three path based measures computing document relatedness conceptual space formed hierarchical organization wikipedia category graph wcg compare proposed approaches standard path length method establish best relatedness measure wcg representation test overall wcg efficiency compare proposed representations bow method evaluation performed two different types clustering algorithms optics means used categorization keyword based search results experiments shown approach outperforms standard path length approach wcg representation achieves better results bow
recycling defined process changes materials new products preventing waste potentially useful materials reducing consumption fresh raw materials energy usage air water pollution many large existing buildings historical importance industrial type office buildings apartments reinforced concrete structure recycled concrete mainly used coarse aggregate filler road construction industry another usage could adding new mixtures far usage led significant decrease mechanical properties new mixture well known cement industry important energy consumer also releaser present paper devoted use recycled concrete materials obtained concrete elements new mixes replacement cement experimental program developed purpose physical physical chemical tests made obtained materials mechanical properties obtained mortar samples also studied
paper examines integrated path planning power management problem solar powered unmanned ground vehicle ugv proposed method seeks minimize travel time ugv area known energy density designing smooth heuristically optimized path allocating vehicle power among electrical components ugv harvests ambient energy along designed path satisfy mission strict energy constraints scalar field first established evaluate solar radiation density discrete locations modified particle swarm optimization method applied search minimal time path wherein energy gathered equal greater energy expended proposed modeling optimization strategy verified computer simulation experimental demonstration note practitioners advancement autonomous technology robotic systems alleviated human operators numerous tedious tasks system endurance plays crucial role current technology employed solar powered robotic systems subject design power limitations varying environments intelligently harvesting energy environments scheduling power consumption optimize desired system performance significantly improve solar robot endurance therefore goal realizing energy autonomy solar powered robotic systems motivates work robotic system access solar energy potentially benefit results work solar panels integrated robotic systems applied missions environmental monitoring search rescue surveillance farming proposed path planning power management strategy potential dramatically extend operation time system
paper presents simple state space representation induction machine transients stator winding inter turn short circuit fault mathematical development dynamic model presented detail differential equations transformed space vector form reduction reasons simulations transient model conducted matlab script using ordinary differential equation ode solver verification purposes results simulation compared ones obtained symmetrical turn fault signature study performed fault detection identification using electromagnetic torque ripple symmetric components transformation stator currents
paper employ extended variable coefficient homogeneous balance method evchb painlev backlund transformation simplified hirota method derive auto backlund transformation multiple soliton solutions multiple singular soliton solutions dimensional potential ytsf equation also obtain variety traveling wave solutions soliton type solutions rational solutions distinct physical structures
purpose construction projects within malaysia plagued time overruns transform successful projects incurring additional costs disagreements litigation cases abandonment help better understand problem purpose paper investigate malaysian project characteristics relation time overruns design methodology approach total malaysian quantity surveying organisations provided data relating recent projects worked project characteristics considered analysis new build refurbishment public private sectors procurement methods used nature projects tendering methods findings public sector projects found prone overruns private sector refurbishment projects experienced better time performance new build construction management demonstrated better time performance design build traditional procurement infrastructure projects negotiated tendering performed better selective open tendering respectively study also developed linear model predict project duration based contract period research limitations implications study adds geographically specific detailed analysis extant literature project performance generally time overruns specifically practical implications findings provide stakeholders information may help mitigate frequency project delays among construction projects especially malaysia originality value analysis modelling time overrun relation malaysian project characteristics way novel
vapor detection using highly sensitive miniaturized resonant sensors great interest many applications including consumer industrial environmental applications operational amplifier based multichannel oscillator interfaces mhz capacitive micromachined ultrasonic transducer array presented chemical sensing applications circuit implemented cmos technology reduce power consumption number wires active area per channel presented integrated circuit also addresses potential frequency locking problem channels allowing open loop gain adjustable chip feasibility developed oscillator chemical sensing application demonstrated two channels operated simultaneously achieved excellent volume sensitivities respectively relative humidity
erythropoietin receptor epor regulates development blood cells full activation normally requires cytokine erythropoietin epo case myeloproliferative neoplasms mpn epo independent signaling epor caused point mutation epor interacting tyrosine kinase janus kinase jak cells expressing jak mutant eight tyrosine residues intracellular domain epor phosphorylated functional role phosphorylations oncogenic signaling incompletely understood evaluate functional consequences phosphorylation tyrosine residues constructed epor mutant substituted eight tyrosine residues phenylalanine expression epor jak mutant failed induce cytokine independent cell proliferation tumorigenesis indicating jak mediated epor phosphorylation reason jak mutant induced oncogenic signaling exhaustive mutational analysis eight epor tyrosine residues indicated three residues tyr tyr tyr required jak mutant exhibit oncogenic activity also showed phosphorylation three residues necessary full activation transcription factor stat critical downstream factor jak induced oncogenic signaling contrast epo stimulation could moderately stimulate proliferation cells expressing wild type jak epor suggesting requirement phosphorylation three tyrosine residues seems specific oncogenic proliferation provoked mutation collectively results revealed phosphorylation tyr tyr tyr epor underlies jak mutant induced tumorigenesis propose targeted disruption pathway therapeutic utility managing mpn
insecure attachment contribute various psychological problems including body dissatisfaction clarified attachment quality anxiety avoidance predict lower body satisfaction relationship maternal paternal patterns distinguished yet aim test aspects adolescents participants large cross sectional survey hungarian children adolescents boys mean age years years measures included self reported body weight height data body satisfaction scale experience close relationships scale relationship structures child depression inventory boys significantly higher body satisfaction worse maternal attachment girls showed worse paternal attachment higher depression higher paternal anxiety avoidance maternal avoidance predicted lower body satisfaction genders adjusted age bmi depression fully mediated relationship dysfunctional maternal attachment lower body satisfaction genders dysfunctional paternal attachment lower body satisfaction girls partially mediated dysfunctional paternal attachment lower body satisfaction boys dysfunctional parental attachment associated adolescents lower body dissatisfaction mediated level depression importance paternal attachment highlighted boys body concerns results suggest handling negative moods parental anxiety avoidance may useful case conceptualizations treatments related adolescents body dissatisfaction requires assessment
inspired matrix based methods used feature extraction selection one matrix pattern oriented classification framework designed previous work demonstrated utilize one matrix pattern effectively improve classification performance practice however matrix based framework neglects prior structural information whole input space made matrix patterns paper aims overcome flaw taking advantage one structure learning method named alternative robust local embedding arle result new regularization term designed expected simultaneously represent globality locality whole data domain boosting existing matrix based classification method knowledge first trial introduce globality locality whole data space matrixized classifier design order validate proposed approach designed rgi applied previous work matrix pattern oriented kashyap classifier matmhks construct new globalized localized matmhks named glmatmhks experimental results broad range data validate glmatmhks inherits advantages matrixized learning also uses prior structural information reasonably guide classification machine design elsevier rights reserved
paper describes uml based foundations model driven architecture forward engineering uml static models paper propose integrated environment designing object oriented enterprise models projected process fast prototyping design object models like use case diagram sequence diagram class diagram etc use object oriented conceptual modeling techniques design develop various applications like commerce banking comparison shopping ticketing online insurance policy management product purchase system etc paper suggests forward engineering generate source code object models ibm rational rose software object oriented source code help software development team analysis maintenance phase well round trip engineering due high security concern use highly secure operating systems platform run web applications regard number trusted operating systems like argus trusted solaris virtual vault developed various companies handle increasing need security novel integration security engineering model driven software expansion approach various advantages observe security checks trusted operating system necessary non essential security checks skipped administrator increase system performance non essential security checks easily identified time requirement analysis example majority web servers deal pure public information majority data web server publicly readable available users users capable change data web server application need security checks reads disk seems like waste cpu cycles real security need web servers seems security write accesses read accesses paper propose code generation class identification modeling web applications uml propose security performance flexibility model maintain balance security performance web applications
using nonlinear aerostatic stability theory together method mean wind decomposition method nonlinear aerostatic stability analysis proposed long span suspension bridges yaw wind corresponding program developed considering static wind load nonlinearity structural nonlinearity taking suspension bridge three towers double main spans example full range aerostatic instability analyzed wind different attack angles yaw angles results indicate lowest critical wind speed aerostatic instability gained initial yaw angle greater degrees suggests perhaps yaw wind poses disadvantage aerostatic stability long span suspension bridge results also show main span upstream goes instability first reason phenomenon discussed
introduction aim paper underline need systematic monitoring patients treated anticholinergic antipsychotic drugs present clinical history year old adult treated quetiapine combination drugs anticholinergic effects case report year old male adult suffering bipolar disorder since treated risperidone compliant due adverse effects including decreased libido erectile dysfunction june decided administrate per day quetiapine combination tropatepine consequent episode agitation aggressiveness june patient receiving diazepam valproic acid loxapine oral solution introduced june patient started mentioning digestive disorders diffuse abdominal pain constipation continued pass gaz june declared abdominal pain worsened despite administration analgesics followed malaise onset vomiting laboratory tests showed leukocytosis neutrophils abdomen radiograph without preparation showed small bowel colonic air fluid levels result scan confirmed occlusive syndrome affecting whole small gut colon patient condition worsened received intramuscular injection loxapine opioid treatment including tramadol morphine clinical condition deteriorated onset generalized abdominal contracture absence abdominal breathing sweating tachycardia beats per minute hypothermia degrees transferred intensive care unit laboratory tests showed metabolic acidosis elevated liver enzymes acute renal failure received volume expansion treated renal replacement therapy antibiotics intubated transferred operating room laparotomy colonic necrosis perforation necrosis small bowel seen patient underwent total colectomy small bowel resection distal ileostomy closure rectal stump onset septic hemorrhagic state required surgery june evolution characterized multi organ failure acute anuric renal failure multiple cardiac arrests systemic bacterial fungal infection july unfavorable outcome lead death summary patient occlusive syndrome due neuroleptics complications including mesenteric ischemia necrotizing colitis discussion conclusion quetiapine like antipsychotics anticholinergic effects including cardiac psychiatric digestive disorders combination anticholinergic drugs decreases intestinal peristalsis without prompt management decrease result colonic ischemia necrosis patients treated neuroleptics onset constipation must alert medical staff systematic monitoring bowel movements performed patient receiving anticholinergic drugs encephale paris
objective work assess potential limitations current practice computational fluid dynamic modeling predicting vortical flowfields generic degree swept diamond wing rounded leading edges wing designed sto avt task group constant naca airfoil section leading edge radius percent chord cfd simulations run different angles attack mach number reynolds number based mean aerodynamic chord match experiments wind tunnel experiments diamond wing carried institute aerodynamics fluid mechanics technische universitat munchen germany include aerodynamic lift drag pitch moment measurements well span wise pressure distributions different chord wise locations data set used validate cfd results results presented demonstrate cfd compare well experiments small angles attack pitch moments predicted sarc turbulence model provide better match experimental results model moderate angles attack high angles attack cfd predictions good flow visualization results show leading edge vortex formed upper surface wing angle attack eight degrees vortex becomes larger stronger angle attack increased increasing angle attack vortex formation point moves upstream vortex core moves inboard towards wing center finally computational results show flow diamond wing relatively steady throughout range angles attack published elsevier masson sas
keeloq algorithm high security usually used wireless codec security lack indicated article according detailed rationale introduction previous attack researches taking examples triple data encryption standard algorithm triple keeloq codec algorithm first proposed experimental results showed algorithm would reduce powerful rolling effect consideration limited computing power embedded microcontroller three bit keys suitable increase crack difficulties improved security method applied intelligent door access system experimental verification extended bluetooth wifi interface employed design lock system door key application constructed android platform wireless communication lock door android key application employed triple keeloq algorithm ensure higher security due flexibility multiformity android key application various keys software based keys solution owned overwhelmed advantages low cost high security humanity green environmental protection
current study examined antisocial personality disorder apd substance use disorder contributed partners reports physical partner violence among single dual substance abusing couples participants heterosexual couples entering treatment one partners met criteria substance use disorder apd diagnosis male partner linked significantly higher male female female male perpetration physical partner violence victimization female partner apd diagnosis associated women reports victimization male partners dual substance use diagnosis emerged moderator effect men apd diagnosis men perpetration physical partner violence victimization significantly reduced partners substance use disorder findings underscore importance partners apd diagnosis substance use status understanding physical partner violence among single dual substance abusing couples
main tendency rolling mills drives modernization outdated analog control systems replacement new digital ones time power section drive remains gives opportunity develop implement adaptive digital control system plants order take consideration high nonlinearity considered different types systems ones change well accepted pid control algorithm tune parameters believed highest chances applied industry main aim research develop apply neural tuner adjust armature current controller parameters two high reversing rolling mill drive online neural tuner consists neural network calculating values trained online help backpropagation method rule base conditions used estimate transient quality whereas consequences values learning rate network output layer neurons modeling experiments conducted model plant consideration used check ability tuner adjust controller parameters back optimal values cope armature winding parameters drift experiments conducted systems neural tuner conventional controller far second type experiments concerned system neural tuner able achieve energy consumption decrease comparing conventional controller based control system
echo state networks esns belonging wider family reservoir computing methods powerful tool analysis dynamic data esn input signal fed fixed possibly large pool interconnected neurons whose state read adaptable layer provide output last layer generally trained via regularized linear least squares procedure paper consider complex problem training esn classification problems semi supervised setting wherein part input sequences effectively labeled desired response solve problem combine standard esn semi supervised support vector machine svm training adaptable connections additionally propose novel algorithm solving resulting non convex optimization problem hinging series successive approximations original problem resulting procedure highly customizable also admits principled way parallelizing training multiple processors computers extensive set experimental evaluations audio classification tasks supports presented semi supervised esn practical tool dynamic problems requiring analysis partially labeled data
chaos complex behavioural pattern associated nonlinear systems association analytical complexity generating system thought minimal experiments show necessarily true increase analytical complexity newer classes dynamical behaviour seen call new classes emergent system study remains far physics represents concerned apply methods increase intrinsically degrees freedom propose four techniques latter complex ification splitting signal flow graph products interpolation extrapolation interesting new behavioural patterns emerge experimentally report attractor symmetries duality time parameters purportedly new route chaos named gibbs
type diabetes mellitus tdm associated increased risk fractures according several studies underlying mechanisms remain unclear although small case control studies indicate poor quality cortical bone studied population based sample women aged years gothenburg randomly invited population register areal bone mineral density abmd measured dual energy ray absorptiometry hologic discovery bone microarchitecture high resolution peripheral quantitative computed tomography pqct extremect scanco medical reference point indentation performed osteoprobe active life scientific women tdm higher abmd compared controls ultradistal tibial radial trabecular bone volume fraction respectively distal cortical volumetric bmd cortical area failure load higher diabetics controls cortical porosity lower mean versus tdm distal radius ultradistal radius tibia adjustment covariates age body mass index glucocorticoid treatment smoking physical activity calcium intake bone active drugs eliminated differences abmd pqct bone variables however bone material strength index bmsi reference point indentation lower tdm versus also adjustment women tdm performed clearly worse measures physical function one leg standing chair stand test timed walking speed compared controls conclusion observed favorable bone microarchitecture difference adjusted abmd elderly women tdm population compared nondiabetics reduced bmsi impaired physical function may explain increased fracture risk tdm american society bone mineral research
many attempts made measure various aspects parenting within variety theoretical frameworks remains much work development reliable valid measures common themes across papers included special issue measurement parenting discussed parenting constructs vital part work prevention scientists support needed researchers engage measurement development fortunately bright spots regard today common fund science behavior change program sponsored national institutes health
antibacterial resistance leadership group arlg funding national institute allergy infectious diseases national institutes health created june mission develop prioritize implement clinical research agenda addresses public health threat antibacterial resistance article reports progress arlg made date fulfilling mission since inception arlg received reviewed study proposals initiated studies executed agreements included data subjects published manuscripts provided opportunities mentees despite substantial progress remains significant work accomplished article also describes considerable challenges lie ahead
novel psychoactive substances nps increasingly prevalent world wide although pharmacological characteristics largely unknown stimulant properties due interactions dopamine transporter dat addictive potential users may realise evaluated binding benzofuran methylpropan amine mapb rat striatal dat means quantitative autoradiography rti effects maps electrically evoked dopamine efflux fast cyclic voltammetry rat brain slices mapb displaced rti concentration dependent manner significant effects voltammetry data suggest mapb reduces rate dopamine reuptake peak dopamitte efflux increased area curve augmented mapb also cause reverse dopamine transport consistent stimulant properties similar amphetamine cocaine molecular modelling docking studies compared binding site dat complex mapb dopamine amphetamine apb mdma cocaine acid rti structural comparison reveals binding mode maps found primary binding site central transniembrane domains overlaps binding modes dopamine cocaine analogues atomistic molecular dynamics simulations show complex maps dat exhibit conformational transitions spontaneously isomerize transporter inward facing state similarly observed dopamine bound dat novel insights offered combination computational methods biophysics neurobiological procedures provide structural context nps dat relate functional properties dat molecular target stimulants crown copyright published elsevier inc rights reserved
backgroundself determined behaviour composed multiple interrelated component elements yet little empirical study researched self determination components choice making goal setting also theoretical relationships drawn component elements self determined behaviour impact disability category therefore study examined profiles combination three self report measures component elements self determined behaviour autonomous functioning problem solving internal locus control two groups learning disabilities emotional disorders methodwe analysed data middle school high school students ages years completed three self report instruments autonomy section arc self determination scale problem solving survey nowicki strickland locus control scale multivariate analysis covariance conducted investigate differences two groups controlling developmental effects age discriminant function analysis examined whether membership two groups could predicted three component elements resultsresults showed group different profiles within combined three component elements self determination groups different single measure component elements self determined behaviour exclusively combination three variables useful confirming membership two dichotomous groups conclusionsscore differences three component behaviour imply two groups different instructional needs therefore require differentiated instructional approaches three measures component elements self determined behaviour collectively separate two groups suggesting component elements considered combination opposed treated individual elements context discussing self determined behaviour
study aims investigate initial perceived knowledge skills high school students information technology security effect online security support tool security portal students perceived knowledge skills security website designed developed extracurricular learning tool improve high school students knowledge skills security exploratory research design descriptive inferential statistical analysis conducted answer research questions data collected participants perceived knowledge skills security questionnaire administered pre test post test using results study indicated majority students aware schools security policies rules similarly students limited knowledge rules using devices homes students perceived knowledge skills virus infection awareness crimes unlicensed products iii security settings operating systems windows firewall defender security settings android except adding owner information security issues related mails except risk associated opening mails unknown senders vii security issues web browsers snss except security privacy settings snss could improved using tools
forensic computing especially field postmortem file system forensics reconstruction lost deleted files plays major role techniques applied end strongly depend specifics file system question various file systems already well investigated fat ntfs microsoft windows systems ext relevant file system linux systems also exist tools famous sleuthkit carrier provide file recovery features file systems interpreting file system internal data structures case ext file system interpretation called superblock essential interpret data ext file system mainly analyzed tools techniques developed predecessor ext principles internal structures remained unchanged however innovations implemented considered file recovery paper investigate changes respect forensic file recovery develop novel approach identify files ext file system even cases superblock corrupted overwritten formatting volume approach applies heuristic search patterns utilizing methods file carving combines metadata analysis implemented approach proof concept integrated sleuthkit framework author published elsevier ltd behalf dfrws
synthetic aperture radar sar image segmentation investigated feature extraction algorithm design characterized two aspects multiple heterogeneous features extracted describe sar images corresponding similarity measures developed independently avoid mutual influences different features order enhance discriminability final similarity objects method called fuzzy clustering based independent subspace iterative optimization fcisio proposed fcisio integrates multiple features objective function iteratively optimized feature subspace obtain final segmentation results strategy protect distribution structures data points feature subspace realizes effective way integrate multiple features different properties order improve computation speed accuracy feature description fcisio design region merging algorithm fcisio use many kinds information quickly merge regions inside true segments experiments synthetic real sar images show proposed method effective robust obtain good segmentation results short running time authors published spie creative commons attribution unported license
using vignettes data collection tool main purpose randomized mixed method study examine emerging adults expectations preferences five different gender role relationship grr types male head female complement male senior female junior partner partner equal female senior male junior partner female head male complement respondents perceptions personal satisfaction grrs future also examined perceptions effects marital status parental status couples various grr vignettes married couples projected greater satisfaction cohabiting couples couples without children viewed similarly quantitative results suggest emerging adults project egalitarian grrs satisfying relationship type projected couple satisfaction anticipated personal satisfaction dependent couples marital parental status qualitative results generally supported quantitative findings dual career couple relationships projected satisfying educators well premarital marriage counselors may able use information help emerging adults consider prepare future relationships work family policymakers also could use information tailor workplace social policies better reflect emerging adults views grrs future relationships
extreme thrombocytosis ext associated increased bleeding risk myeloproliferative neoplasm mpn patients included high risk category treatment guidelines treatment patients ext studied prospective trials study physicians approaches ext distributed web based questionnaire clinical case scenarios members mpn working groups cases included low thrombotic risk essential thrombocythemia either jakvf calr mutation polycythemia vera ext either without leukocytosis patient needing urgent orthopedic surgery poorly controlled patient acute cerebral venous sinus thrombosis responses received physicians variable case scenarios country practice significant influence physician response usa israel physicians responded similarly cases differently europe physicians treatment asymptomatic jakvf positive target platelet count cytoreduction significantly influenced physician years experience responses influenced volume mpn practice whether mpn considered major interest physician results show lack consensus manage mpn patients ext randomized controlled trials properly designed address questions needed
brassica vegetables including cauliflower characterized high number valuable metabolites act effectively cancer chemo prevention already revealed several studies work investigates effect type container low density polyethylene packages oriented polystyrene ops packages selected quality parameters frozen cauliflower vegetable subjected blanching freezing months storage every stage experiment material examined terms dry matter vitamin total polyphenols content antioxidant activity statistical analysis proved type container considerable effect levels aforementioned constituents antioxidant activity freeze stored vegetables
aim study assess prevalence long term antipsychotic use community dwelling patients dementia considering hospitalization periods exposure retrospective study carried paca alzheimer cohort included patients million inhabitants three groups patients identified according longest exposure aps without interruption nonusers short term users successive months without discontinuation long term users sensitivity analyses hospitalization periods carried percentage patients least one dispensing stable study period long term users increased hospitalization periods counted exposure comparison nonusers users took benzodiazepines antidepressants short term users men odds ratio confidence interval older years old long term users exposed benzodiazepines study showed long term use remained frequent community dwelling patients dementia also showed prevalence long term users almost doubled hospitalization periods counted exposure underlines need consider hospitalization periods assessing medication exposure populations frequent periods hospitalization copyright wolters kluwer health inc rights reserved
involved caring fatherhood contributes health wellbeing children women men corollary also true men women children affected fathers involved supportive children many factors affect fathers involvement including women attitudes history nature relationship mother father cultural context study explores gatekeeping impact father involvement among black south africans rural kwazulu natal among married couples gatekeeping occurs respect childcare housework women attempts validate maternal identity according socially culturally constructed gender roles among unmarried non resident parents women control father child contact involvement mothers families either facilitating inhibiting father involvement context found cultural gatekeeping huge impact father involvement non payment inhlawulo lobola regulating father child involvement country like south africa high non marital fertility father child non residence future research parenting family programmes focus strategies encourage positive paternal involvement well maternal cultural support father involvement regardless parental relationship residence status
advancement software defined networking sdn redefining traditional computer networking architecture role control plane sdn importance sdns referred network operating systems oss however robustness security network overlooked paper report three main issues pertaining network oss first identified vulnerabilities could exploited malicious buggy applications running network oss also identified four major attack vectors could undermine network operations denial service global data manipulation control plane poisoning system shell execution demonstrated real world attacks launched commonly used network oss without significant effort second present method address attacks analyzing network applications running network oss identify behavioral features enabled extraction permission set network application based work permission based malicious network application detector introduced examines permission set application prevents executing without permission system shows almost performance overhead copyright john wiley sons ltd
recent years environmental sustainability demanded progressive increase waste recycling general waste value added utilisation construction industry particular regards application construction demolition wastes geotechnical works noticed use recycled aggregates found mostly road construction value added utilisation geosynthetic reinforced structures almost unexplored field paper presents results physical mechanical environmental characterisation recycled well direct shear behaviour three recycled geosynthetic interfaces material collected recycling plant came demolition single family houses cleaning land illegal deposits two geogrids one geocomposite reinforcement high strength geotextile used assess behaviour geosynthetic interfaces environmental characterisation carried leaching tests show environmental concerns direct shear test results demonstrated properly selected compacted exhibit shear strength similar natural soils coefficients interaction achieved geosynthetic interfaces compare well reported literature soil geosynthetic interfaces similar conditions supports feasibility using recycled materials backfill geosynthetic reinforced structures
forty years ago keller segel presented mathematical continuum model cell migration chemotaxis main transport mechanism together dispersion decade ago chaplain lolas developed model cancer cell migration also accounted transport due interaction cells fibers extracellular matrix ecm called haptotaxis effect recent cancer research emphasizes role played physical cues tumor microenvironment besides biochemical cues role cell cell cell ecm adhesion pattern formation caused detachment small cell clusters primary tumor iii elevated pressure associated primary tumor interstitial fluid flow physical resistance forces surrounding ecm hence need mathematical frameworks properly integrate aspects coherent formulation apply multiphase continuum based approach consider cancer cells interstitial fluid two distinct compressible phases whereas ecm non mobile component principle mass momentum balance employed proliferation apoptosis cell force generating mechanisms capillary pressure surface tension represent cell cell cell ecm adhesion well resistance forces microenvironment accounted test model different scenarios compare reported experimental observations find proposed multiphase model general enough adequately address mentioned issues elsevier ltd rights reserved
ige mediated allergies particular allergic rhinoconjunctivitis asthma reached epidemic proportions affecting one third population developed countries effective treatment allergies specific immunotherapy sit involves injection increasing doses allergen extract allergic individuals current form sit first introduced recently celebrated birthday treatment hay fever concept therapy time straightforward believed pollen contained toxins patient could vaccinated however understanding became blurred discovery ige antibodies effector molecules allergic response subsequent research focused idea sit induce tolerance keeping ige antibodies bay review discuss various hypotheses mechanism sit put forward concept allergens may viewed protoxins need activated ige antibodies within framework protoxin neutralizing antibodies key effector molecules shift treg cells mainly contributes efficacy sit helping cells produce neutralizing igg antibodies
objectives psoriasis chronic autoimmune disease involving complex network cytokines interleukin tested hypothesis serum level useful indicator disease activity predicts treatment response biologics patients psoriasis methods analyzed psoriasis patients treated biologics infliximab ifx adalimumab ada ustekinumab ust hospital disease severity assessed using psoriasis area severity index pasi score disease activity score based reactive protein das crp results treatment serum levels significantly correlated pasi scores patients psoriasis vulgaris das crp patients psoriatic arthritis serum levels significantly decreased ifx ada therapy psoriatic arthritis serum levels endpoint tended lower patients achieved das crp european league rheumatism remission criteria patients conclusion serum level may useful biomarker assessing disease activity patients psoriasis predicting responsiveness joint symptoms biologic treatment
single experiment year old children examined whether changes children make response cross examination style questioning vary function delay persist subsequent interviews children visited local police station days later interviewed direct examination format either days months later children interviewed cross examination format designed persuade change original responses one week following cross examination interview direct examination questions repeated relative direct examination scores accuracy children reports decreased significantly cross examination irrespective delay children interviewed week cross examination however responses accuracy levels similar observed direct examination interview cross examination children made changes earlier testimony even memory event remained intact
effect bariatric surgery health related quality life hrqol varies greatly might caused diversity questionnaires used assess hrqol weight loss studied population study assesses relationship weight loss hrqol primary roux gastric bypass rygb patients using obesity specific impact weight quality life lite iwqol lite generic rand questionnaire hrqol weight parameters assessed months rygb surgery hrqol assessed using iwqol lite obesity specific questionnaire consisting one total score five domains rand generic questionnaire consisting two subtotal scores physical health summary phs mental health summary mhs nine scales two thousand one hundred thirty seven patients included hrqol improved significantly rygb preoperative bmi negatively related baseline phs iwqol lite total percentage total weight loss twl positively related hrqol score follow moments change hrqol baseline months related twl months subtotals rand iwqol lite total score hrqol improves rygb higher twl related greater improvement hrqol better hrqol months rygb variance effect rygb surgery hrqol explained questionnaire used weight loss population
hypothesised belief conspiracy theories would predicted general tendency attribute agency intentionality unlikely exist hypothesised tendency would explain relationship education level belief conspiracy theories lower levels education found associated higher conspiracy belief study participants likely agree range conspiracy theories also tended attribute intentionality agency inanimate objects predicted relationship accounted link education level belief conspiracy theories replicated finding study whilst taking account beliefs paranormal phenomena results suggest education may undermine reasoning processes assumptions reflected conspiracy belief
paper design sure independent ranking screening procedure censored regression csirs short ultrahigh dimensional covariates inverse probability weighted csirs procedure model free sense specify parametric semiparametric regression function response variable covariates thus robust model mis specification model free property appealing ultrahigh dimensional data analysis particularly lack information underlying regression structure csirs procedure also robust presence outliers extreme values merely uses rank censored response variable establish sure screening ranking consistency properties csirs procedure number covariates satisfies positive constant available sample size advantages csirs existing competitors demonstrated comprehensive simulations application diffuse large cell lymphoma data set
production specific mental state terms types functions caregivers children caregivers children asd assessed two contexts parent story telling task child story telling task caregivers children asd produced less causal talk proportionally less desire cognitive talk caregivers children focusing variation asd sample caregivers children production different mental state references varied context predicted different child characteristics theory mind autism severity language level conclude caregivers likely adjusting different aspects mental state input depending different aspects child development although adjustments may always optimal
novel low voltage high power multi phase inverter presented based already designed iscad machine specification electrical power link voltage achieved spreading high currents corresponding power losses phase machine built phase connected one dedicated half bridge includes power components driver circuit requirements electrical circuits components investigated ensure safe operation system voltage transients simulations show electrical thermal behavior printed circuit boards experimental results validate simulations show system boundaries
although functional abnormalities salience network associated schizophrenia acute effects nicotine function network dynamics resting state patients poorly understood study effects nicotine patch placebo salience network connectivity examined patients schizophrenia healthy subjects hypothesized abnormal connectivity salience network major networks executive network patients placebo administration amelioration difference nicotine also examined effects nicotine betweenness centrality measure influence region information transfer throughout brain local efficiency measure local information transfer network hybrid independent component analysis ica seed based connectivity approach implemented salience network extracted ica cortical network peaks anterior cingulate cortex acc left right insula used seeds whole brain seed voxel connectivity analysis significant drug diagnosis interactions observed acc seed superior parietal lobule ventrolateral prefrontal cortex significant interaction effect also observed left insula seed middle cingulate cortex placebo conditions abnormal connectivity predicted negative symptom severity lower global functioning patients significant drug diagnosis interaction also observed betweenness centrality acc results suggest nicotine may target abnormalities functional connectivity salience executive network areas schizophrenia well affect ability salience network act integrator global signaling disorder elsevier ltd rights reserved
since conventional cascade controller electric motor drives requires accurate information system parameters load conditions achieve desired performance paper presents new practical control structure improve robust performance parameter uncertainties two first order disturbance observers dob incorporated cascade structure preserve nominal performance analysis robust performance dob presented using singular perturbation theory simulation results suggest proposed controller used effectively additional compensator conventional cascade scheme
study present modular worm like robot utilizes voice coils new paradigm soft robot actuation drive electronics incorporated actuators providing significant improvement self sufficiency compared existing soft robot actuation modes pneumatics hydraulics body plan robot inspired phylum annelida consists three dimensional printed voice coil actuators connected flexible silicone membranes electromagnetic actuator engages neighbor compress extend membrane segment sequence actuated results earthworm inspired peristaltic motion find minimum three segments required locomotion due modular design robots length quickly easily assembled addition actuation voice coils provide audio input output capabilities demonstrate transmission data segments high frequency carrier waves using similar mechanism note passing power coupled coils neighboring modulesor external power sourceis also possible voice coils convenient multifunctional alternative existing soft robot actuators self contained nature ability communicate ideal modular robotics additional functionality sound input output power transfer become increasingly useful soft robots begin transition early proof concept systems toward fully functional highly integrated robotic systems
paper presents single stage ultra low power fully differential operational transconductance amplifier ota rail rail linear input range operating weak inversion region input core ota comprised source degenerated flipped voltage follower fvf based bulk driven class input pair regenerative feedback loop inserted boost bulk transconductance gib proposed ota utilized selfcascode current mirror loads increase open loop gain nominal intrinsic value provided khz gain bandwidth gbw consuming quiescent power single power supply load proposed ota unity gain configuration ensured reduced total harmonic distortion thd frequency signal swing fully differential class input output structures ensured increased gain gbw slew rates output swings reduced nonlinearity common mode substrate noise cadence virtuoso environment using gpdk standard well cmos process technology used simulate proposed circuit
interoceptive awareness linked emotional social cognition impaired individuals autism spectrum disorder asd unknown ability associated age either typical atypical development used standard test interoceptive accuracy investigate questions children adults without asd perceived number heartbeats time intervals compared actual heart rate determine effects group age heart rate mental counting ability accuracy assessed using multiple regression post hoc correlations performed clarify significant interactions age unrelated groups relationship positive typical development negative asd results suggest cognitive ability moderates effect age differently autism typical development
examined relationship contact police officers citizens meta stereotypes citizens work related well ninety three police officers police stations low high crime regions france completed questionnaire expected negative well police officers predicted negative contact citizens belief police officers stereotyped negatively citizens moreover relationship negative contact negative well mediated police officers beliefs police officers perceived negatively citizens whereas perceptions citizens mediate relationship interestingly level crime influence relationships together research shows important role beliefs one group stereotyped contact another group may consequences people well
human gait recognition active research topic computer vision generally based data obtained images videos applied computer vision technology classify pathology related changes gait young children using foot pressure database collected using gaitrite walkway system foot positioning changes children development also investigated possibility age estimation based data results demonstrate data collected gaitrite system used normal pathological gait classification combining age information normal pathological gait classification increases accuracy classifier novel approach could support development accurate real time economic measure gait abnormalities children able provide important feedback clinicians regarding effect rehabilitation interventions support targeted treatment modifications
driven accelerator cyciae cyclotron designed china institute atomic energy beijing radio ion beam facility project cyclotron system designed use two power sources drive two half wavelength cavities respectively two dee accelerating electrodes kept separately inside cyclotron accelerating voltages maintained phase efforts llrf control analog digital hybrid llrf system developed achieve cavity tuning control dee voltage amplitude phase stabilization etc analog subsystems designs focused signal conversion tuning control dee voltage regulation digital system provides signal source aligns cavity phases maintains finite state machine digital parts combine analog functions provide llrf control brief system hardware introduction given paper followed review several major characteristics digital control mev cyclotron llrf system commissioning also introduced optimization process done changing digital parts elsevier rights reserved
background purpose atypical parkinsonian disorders apd frequently overlap clinical presentations making differential diagnosis challenging early stages present study aimed evaluate accuracy fluoro deoxy glucose positron emission tomography statistical parametric mapping spm optimized procedure supporting early differential diagnosis apd methods seventy patients possible apd retrospectively included large clinical cohort included patients underwent fluoro deoxy glucose positron emission tomography within months first clinical assessment diagnostic follow optimized spm voxel wise procedure used produce maps brain hypometabolism single subjects classified experts blinded clinical information compared accuracy first clinical diagnosis spm map classifications diagnosis follow reference standard results first diagnosis patients classified possible apd progressive supranuclear palsy corticobasal degeneration dementia lewy bodies multiple system atrophy apd uncertain diagnosis providing sensitivity specificity accuracy respect reference standard spm map classification showed sensitivity specificity accuracy significant agreement diagnosis follow conclusions spm map classification entry predicted second diagnosis follow indicates significantly superior role early identification apd subtypes particularly cases uncertain diagnosis use metabolic biomarker entry instrumental work apd may shorten diagnostic time producing benefits treatment options support patients
previous work shown robust differences north americans east asians form impressions people present research examines whether tendency weigh initial information heavilythe primacy effectmay another component cultural differences specifically tested whether americans would likely use first impressions guide person perception compared japanese participants experiment participants read vignette described target person behaviour rated target personality reading vignette trait information given create expectation target personality data revealed americans used initial information guide judgments target whereas japanese sample based judgments information evenly thus americans showed stronger primacy effect impression formation japanese participants engaged data driven processing
objective objective study analyze association intimate partner violence women maternal educational practice directed children beginning formal education methods cross sectional study carried mother child pairs registered family health strategy health district city recife state pernambuco brazil integrates prospective cohort study designed investigate consequences exposure intimate partner violence relation child born maternal educational practice assessed parent child conflict tactics scale intimate partner violence questionnaire adapted multi country study women health domestic violence world health organization intimate partner violence referred last months defined specific acts psychological physical sexual violence inflicted women partner crude adjusted prevalence ratios estimated association studied using log binomial regression results prevalence intimate partner violence violent maternal educational practice use non violent discipline mentioned women coexisting violent strategies discipline children whose mothers reported intimate partner violence presented higher chance suffering psychological aggression conclusions violence suffered mother interferes parental education findings show high prevalence violent maternal educational practice pointing need interventions minimize damage violence women children
dengue virus denv infection considerable health impact tropical subtropical countries worldwide escalation infection rates greatly increases morbidity mortality commonly deaths due dengue hemorrhagic fever dengue shock syndrome although development effective long lasting vaccine major aim control prevention denv infection currently licensed vaccine limitations less satisfactory thus remains important need identify effective tolerable medications treatment denv infected patients early phase prevent progression fatal outcomes minimize deaths patients develop severe complications review address several specific points including approaches identify anti denv medications recent advances development potential compounds targeting denv infection experience clinical trials regimens denv infection available medications potential clinical trials denv infection reasons unsuccessful outcomes challenges anti denv treatments directions developing selecting better anti denv strategies review provides useful guidance clinicians selecting drugs denv infected patients severe manifestations potential fatal disease progression basic researchers seeking develop effective anti denv regimens elsevier inc rights reserved
finite element software used analyze dynamics three dimensional numerical control laser cutting machine method analysis dynamic structure using modal analysis main moving parts driving beam basis angles kinematics dynamics whole equipment stress strain displacement stiffness system analysis research cutting machine design provide theoretical basis structural optimization
reliability growth models particular project risk management generally improving reliability system product limited constraints cost time many possible tasks carried identify design weaknesses system development paper considers allocation problem subset tasks undertake method applicable project risk management generally work motivated reliability growth programmes utilise model reliability growth based efficacy matrix developed engineering experts aerospace industry develop general multi attribute utility function based targets cost time test system reliability optimal subset identified maximising prior expected utility derive conditions model parameters risk aversion loss aversion based observed properties preference give conditions multivariate risk aversion general form utility function method illustrated using example informed work aerospace organisations elsevier rights reserved
bisphosphonates currently major class drugs used treatment osteoporosis disease leads bone fragility increase fracture risk affects hundreds million elderly individual worldwide commercially available bisphosphonates achiral albeit activity demonstrated related inactivation specific enzymes cinchona alkaloid urea derivatives efficient organocatalysts asymmetric aldol reaction ketones isatin containing bisphosphonate precursor provide class new chiral enantioenriched potentially anti resorption bone drugs high chemical yields generally achieved wide array substrates tested several cases range could observed
although brushless doubly fed induction machine dfim great potential generator system large scale wind turbines complexity far retained commercial breakthrough paper contributes combining brushless dfim finite element modelling multi objective optimization static brushless dfim model applied nsga multi objective optimization algorithm result accurate fast brushless dfim design optimization tool tool used generate machine design optimized performance fits fixed volume frame size optimization results different brushless dfim construction variations compared best designs construction variation analysed detail using time stepping brushless dfim model provides good insight effects different construction variations torque ripple induced time harmonics optimized design best construction variation selected manufactured prototype machine
consumers want ensure enterprise data stored securely obliviously cloud data objects access patterns revealed anyone including cloud provider public cloud environment created detailed ontology describing oblivious cloud storage models role based access controls place manage risk developed algorithm store cloud data using oblivious data structure defined paper also implemented oblivicloudmanager application allows users manage cloud data validating storing oblivious data structure application uses role based access control model collection based document management store retrieve data efficiently cloud consumers use system define policies storing data obliviously manage storage untrusted cloud platforms even unfamiliar underlying technology concepts oblivious data structures
introduction eating disorders severe conditions featuring abnormal eating patterns pervasive distressing concerns one body image relatively common considerable high mortality rate costs public health aim paper review recent findings field treatment strategies including psychotherapeutic pharmacological non pharmacological novel approaches evidence acquisition review recently published randomized controlled clinical trials rcts treatment undertaken reported according preferred reporting items systematic reviews meta analyses prisma statement recommendations bibliographic search yielded records screening articles finally included concerned patients anorexia nervosa bulimia nervosa binge eating disorders bed mixed evidence synthesis substantial developments psychological therapies within last years evidence conforming importance multidisciplinary team approaches expanding indications cognitive behavioral family based interventions pharmacological treatment remains poorly evidence based involvement carers treatment programs increasingly given importance conclusions research efforts needed elucidating effectiveness differential indications stepped care approaches involving different settings psychotherapy models age type
objective study aims determine whether cystatin associated hiv disease hiv associated neurocognitive impairment nci methods participants included hiv hiv older adults age years examined university california san diego hiv neurobehavioral research program cystatin biomarker kidney functioning linked poor health outcomes measured blood participants completed comprehensive neurocognitive assessment used define global domain nci results hiv group significantly higher cystatin concentrations hiv group associated nci hiv group using binary variable including relevant covariates multivariate modeling confirmed nci associated higher cystatin levels conclusions results confirm hiv older adults higher cystatin hiv older adults identify cystatin may associated nci population particularly use tenofovir blood biomarker may useful clinical tool identify older hiv persons greater risk cognitive decline
computerized obstructive sleep apnea detection necessary speed sleep apnea diagnosis research assisting medical professionals moreover development device monitor sleep apnea low power portable requires reliable successful sleep apnea detection scheme article problem automated sleep apnea detection using singe lead electrocardiogram ecg signals addressed first segments ecg signals decomposed using data adaptive signal decomposition scheme namely tunable factor wavelet transform tqwt three statistical features extracted tqwt sub bands train test matrices formed afterwards matrices fed classifier identify non apneic apneic ecg signal segments work new machine learning algorithm namely random sampling boosting rusboost implemented perform classification first time tqwt along rusboost employed automatic sleep apnea detection knowledge overall algorithmic performance method inspected various values tqwt parameters optimal values parameters investigated determined efficacy appropriateness rusboost demonstrated opposed commonly used classification models algorithmic performance sleep apnea identification scheme also evaluated existing detection algorithms literature experimental outcomes manifest sleep apnea identification scheme performs better existing works sensitivity specificity accuracy anticipated owing use one channel ecg signal proposed method ideal device implementation eliminate onus clinicians analyzing large bulk data manually expedite sleep apnea diagnosis
visualizing sets isosurfaces scalar ensemble fields difficult task due inherent occlusion effects yet often required analyze uncertainty represented ensemble paper present novel visualization technique ensembles isosurfaces based screen space silhouettes using silhouettes displayed information reduced avoid occlusions yet major shape surfaces maintained approach preserves spatial coherence make assumption underlying surface distribution providing additional mechanisms picking clustering cutting animation enable user explore ensemble surfaces interactively
paper reviews efficacy safety systemic absorption estradiol investigational low dose beta estradiol vaginal softgel capsule designed treat vulvar vaginal atrophy vva postmenopausal women improved user experience phase nct phase rejoice nct studies significantly improved proportions vaginal superficial parabasal cells vaginal phase study decreased severity dyspareunia vaginal dryness vulvar vaginal itching irritation two randomized phase trials estradiol max auc significantly lower doses approved vaginal estradiol tablet substudy rejoice trial showed estradiol avg auc different placebo days associated higher avg auc versus placebo days levels remained within postmenopausal range estradiol day values three doses different placebo demonstrating estradiol accumulation doses well tolerated acceptable safety profile reviewed studies local vaginal efficacy significantly better placebo overall safety profile similar placebo negligible low systemic estradiol absorption observed whether given approved may alternative option women symptomatic vva without increasing mean systemic estradiol absorption postmenopausal levels authors published elsevier ireland ltd
developed validated efficient robust method simultaneous quantification fatty acid species human plasma via tof method characterized robustness accuracy precision covering wide range fatty acid species various saturation degrees including short chain fatty acids beginning long chain fatty acids fatty acids methylated prior analyses subsequently detected fatty acid methyl esters means tof highly substituted polar column allowed separation geometrical positional isomers fatty acid species method applied plasma samples strictly diet controlled clinical smoking cessation study including smokers followed course three months quit statistical significant alterations within fatty acid profile observed comparing baseline subjects still smoking one week one month three months smoking cessation months smoking cessation partial recovery alterations fatty acid profile evoked smoking observed conclusion developed fatty acid profiling method using tof proven reliable tool quantitative determination individual fatty acid species within clinical studies elsevier rights reserved
germany appears set miss reduction target result ideas additional political measures put forward one idea involves early phase coal fired power plants however possible impacts phase energy system yet fully analyzed therefore apply german energy system model analyze impacts calculate three different scenarios first represents business usual scenario second takes coal phase account third scenario achieve reduction second without forced implement coal phase three scenarios show definitive coal phase would result relatively small amount additional however equal reduction obtained using different strategy slightly lower costs latter scenario additional costs also distributed evenly across sectors sensitivities analyzed show robustness conclusions drawn summary analysis outlines consequences could arise excluding several options parallel technology portfolio elsevier ltd rights reserved
acoustic emission traditionally regarded explicit measurable index microcracking geomaterials accelerative cracking point first introduced based different characteristics acoustic emission stable fracture propagation stage accelerative cracking point located fracture initiation strength critical energy release point point causing fatal uncontrolled fracture materials microcracking dominates real mechanical characteristics materials reflected conventional mechanical experimental results stress level beyond accelerative cracking point stable fracture propagation stage stage non stress controlled fracture materials could arise found unstable fracture propagation stage stress releasing time experiments also performed time dependent concerns stress level equal beyond fracture initiation strength materials onset stress level gradually decreases previous maximum stress level stress releasing time increases
sclerostin antibodies increase bone mass stimulating bone formation however human animal studies show bone formation increases transiently returns pre treatment level despite ongoing antibody treatment understand mechanism action studied time course bone formation correlating rate extent accrual bone mass strength sclerostin antibody treatment ovariectomized ovx rats treated sclerostin antibody scle weekly sacrificed baseline weeks post treatment scle treated rats serum pinp ocn rapidly increased week peaked around week returned ovx control levels week transcript analyses distal femur revealed early increase bone formation followed sustained decrease bone resorption genes lumbar vertebral osteoblast surface increased week bone formation rate bfr increased week parameters ovx control week bone formation primarily result modeling based formation endocortical periosteal bfr peaked around week ovx control respectively bfr declined remained higher ovx control surfaces week histomorphometric analyses showed increase week bmd continued increase mid femur femoral neck week biomechanical tests showed similar improvement bone strength weeks bone strength plateaued weeks data suggest bone formation scle treatment rapid modeling formation dominated ovx rats although transient bone formation response persists longer cortical trabecular bone elsevier inc rights reserved
facial traumas common children often unconsidered facial injury responsible impressive bleeding rich vascularization face bleeding often underestimated immediate arterial vasoconstriction strong children blood volume newborn total reaching one year age evaluation must rigorously performed due risk sudden decompensation regarding wounds primary repair must performed directly neat optimal case damaged tissues rule keep maximum integrity limit debridement careful repair often requires general anesthesia especially young children facilitate perfect joining edges mucocutaneous lines losses substance treated directed cicatrization flaps never performed children first intention reasons developed given elasticity facial skeleton fractures require brutal shock occur clinical signs misleading instance specific sometimes ignored fractures show weakly symptomatic signs fractures condylar orbital floor respective complication temporomandibular bone ankylosis definitive diplopia possible children abuse suspected case different age lesions discrepancies told story types injuries vital urgency eliminated orbital emergency first considered facial traumas within ophthalmology specialty wounds contusions globe often evaluated threaten vision second emergency orbital floor fracture trapdoor type specific child combined motionless eye uncontrollable vomiting second true urgency involves prognosis oculomotricity requires emergency surgery finally dental trauma overlooked functional aesthetic consequences primary cicatrization usually rapid scars remain inflammatory long time risk hypertrophy exists case contusions lacerations associated wounds also puberty locations age interfere result growth either improve worsen initial result depending location mechanism secondary specialized prolonged managing monitoring capital functional aesthetic psychological points view elsevier masson sas rights reserved
cutaneous involvement characterized urticarial lesions without angioedema itch commonly observed routine medical practice clinical approach may still remain complex real life several diseases may display similar cutaneous manifestations urticaria common disease characterized sudden appearance wheals without angioedema term chronic urticaria encompasses group conditions different underlying causes different mechanisms sharing clinical picture recurring wheals angioedema least weeks hereditary angioedema hae rare disorder characterized recurrent episodes non pruritic non pitting subcutaneous submucosal edema affecting extremities face throat trunk genitalia bowel referred attacks hae autosomal dominant disease caused deficiency functional inhibitor due mutation inh gene serping gene characterized clonal proliferation mast cells leading accumulation possibly mediator release one organs childhood two main forms mastocytosis systemic cutaneous clinical features skin lesions urticaria angioedema mastocytosis may differ depending aetiologic factors underlying pathophysiological mechanisms diagnostic process stepwise approach routine clinical practice reviewed hae mastocytosis resulting integrated method improved management cutaneous diseases taking account usually conditions also relevant impact quality life children affecting social activities behavior availability care pathways could helpful disentangle diagnostic issue achieving cost effective ratio
estimated exposure ambient air pollutants analyzed associations allergic diseases enrolled children atopic dermatitis asthmatic adults living seoul metropolitan area korea followed months august december parents patients recorded symptom scores daily basis exposure particulate matter diameter nitrogen dioxide estimated four different ways individual using measurements nearest air quality monitoring station residential houses measurements modified indoor level air pollutants time activity individual measurements modified respectively daily inhalation intakes air pollutants generalized linear mixed model glmm used analyze associations exposure metrics clinical symptoms adjusting ambient temperature humidity age season gender time trend exposure metrics showed different distributions symptoms asthma positively associated exposure exposure metrics effect size exposure asthma symptoms slightly greater inmetrics inhalation capacity dis thosewithout aqs pattern observed exposure associated symptomag gravation childhood adult asthma different exposure estimates may used evaluate impact air pollution different allergic diseases elsevier rights reserved
background mir small non coding rna known dysregulated osteoarthritis role mir human remains unclear aim study identify function molecular target chondrocytes pathogenesis material methods function mir assessed gain function studies human chondrocytes potential targets mir predicted using series bioinformatics intersection analysis confirmed luciferase reporter assay gene expression quantified using quantitative reverse transcription pcr qrt pcr assays protein production quantified western blot analysis results fitc apoptosis assay results indicated upregulation mir led increase apoptosis rate chondrocytes bioinformatic analysis identified potential target sites mir located untranslated region gpdl dual luciferase reporter assays results showed gpdl target gene mir furthermore western blot qrt pcr analysis demonstrated mir inhibited gpdl gene expression increased gpdl decreased mirna observed tissues osteoarthritis patients moreover found highly negative correlation mirna gpdl conclusions results demonstrated mir may play important role pathogenesis targeting gpdl regulating chondrocyte apoptosis
parental adhd symptomatology related impairments robustly associated youth adhd across decades work notably factors may impede typical development child self regulation capabilities neurobiological interpersonal processes high heritability estimates disorder suggest effects likely genetically mediated least part variation within dopamine receptor gene drd shown moderate parental influences youth adhd use multiplex family design samples families included multiple affected members may facilitate identification additional gene variants interest advance understanding gene environment interplay regard parenting thirty multiplex families consisting individuals youth parents completed multi stage multi informant diagnostic neurocognitive assessment measures parenting provided saliva samples dna analyses sanger sequencing drd gene yielded rare variants polygenic risk score computed parents youth generalized estimating equations gee examined predictive effects parental adhd symptoms parental neurocognitive functioning poor parenting dimensions youth adhd well moderation effects parental youth drd variants findings indicated parental drd variants moderated impact parental adhd neurocognitive functioning youth adhd symptoms youth drd variants moderated impact parental inconsistent discipline child adhd cases stronger associations observed individuals risk variants exploratory findings highlight potential utility multiplex family design examining interplay parent child characteristics predicting youth outcomes
background past decade concept lean spread rapidly within healthcare sector lack instruments measure staff perceptions lean adoption thus aim present study develop questionnaire measuring lean healthcare based liker description lean adapting existing instrument developed service sector methods mixed method design used initially items service sector instrument categorized according liker principles describing lean within four domains philosophy processes people partners problem solving items lacking three liker principles therefore developed novo think aloud interviews conducted healthcare staff different professions contextualize examine face validity questionnaire prototype thereafter adjusted questionnaire psychometric properties assessed basis cross sectional survey among staff working primary care results think aloud interviews led adjustments questionnaire better suit healthcare context number items reduced confirmatory factor analysis adjusted questionnaire showed generally acceptable correspondence liker description lean internal consistency measured using cronbach alpha factors liker description lean factor people partners three factors test retest reliability measured intra class correlation coefficient ranged four factors conclusions designed questionnaire capturing staff perceptions lean adoption healthcare basis liker description lean healthcare questionnaire lihcq showed generally acceptable psychometric properties supports usability measuring lean adoption healthcare suggest research focus verifying usability lihcq healthcare settings adjusting instrument needed
antibiotics resistance phenomena aeromonas hydrophila become serious economic public health problems world aquaculture industry human health care study investigate instinct antibiotics adaptive mechanism pathogen itraq isobaric tags relative absolute quantitation based quantitative proteomics technologies performed compare differential expression hydrophila planktonic status response chlortetracycline ctc stress identified total proteins including altered proteins increasing decreasing abundance proteins following bioinformatics analysis showed many metabolic metabolism pathways carbon metabolism pyruvate metabolism glycolysis gluconeogenesis trend regulated whereas beta lactam resistance rna degradation amino acids biosynthesis processes likely increase ctc stress related pyruvate metabolism beta lactam resistance processes mrna level measured using pcr method thus understanding behaviors hydrophila response ctc would helpful reveal antibiotics adaptive mechanism development novel antibiotics therapy graphcis
introduction hospital readmissions common expensive key target medicare value based purchasing vbp program validated risk assessment tools hospital score lace index developed identify patients high risk hospital readmission targeted interventions aimed reducing rate readmission study aims evaluate utility hospital score lace index predicting hospital readmission within days moderate sized university affiliated hospital midwestern united states materials methods adult medical patients underwent one icd defined procedures discharged siu som hospitalist service memorial medical center mmc october march studied retrospectively determine hospital score lace index significant predictors hospital readmission within days results study period discharges recorded hospitalist service analysis includes data discharges patients died hospital stay transferred another hospital left medical advice excluded patients readmitted hospital within days receiver operating characteristic evaluation hospital score patient population shows statistic indicating good discrimination hospital readmission brier score hospital score setting indicating good overall performance hosmer lemeshow goodness fit test shows chi value value receiver operating characteristic evaluation lace index patient population shows statistic indicating poor discrimination hospital readmission brier score lace index setting indicating good overall performance hosmer lemeshow goodness fit test shows chi value value discussion single center retrospective study indicates hospital score superior discriminatory ability compared lace index predictor hospital readmission within days medium sized university affiliated teaching hospital conclusions internationally validated hospital score may superior lace index moderate sized community hospitals identify patients high risk hospital readmission within days
water scarcity new issue neither water pollution earth surface covered water available fresh water moreover pollution water resources dramatically increased problem water scarcity last century bioremediation presents cheap effective solution problem particular halophiles found effective hypersaline wastewater treatment therefore paper propose nonlinear mathematical model study removal pollutant using halophiles hypersaline environment analysis model carried using stability theory differential equations results indicate halophiles help removing organic pollutant also help conversion saline water fresh water numerical simulations along sensitivity analysis performed support analytical results
paper considers problem many many disjoint paths hypercube faulty vertices obtains following result integer fault free vertex least two fault free neighbors exist fully disjoint fault free paths linking contain least vertices linear algorithm finding disjoint paths also given result improves known results sense elsevier rights reserved
geotextiles commonly used globally making control material selection influence geotextiles properties important research topic study aims explore effects ratio high strength polyethylene terephthalate hpet fiber kevlar fiber hybrid geotextiles first stage hpet polyethylene terephthalate pet fiber combined make hpet pet hybrid geotextile tested porosity water permeability determining optimum hpet pet ratio second stage content pet fibers hpet fibers kevlar fibers mixed various ratios form kevlar hpet pet hybrid geotextiles experimental results show increase content hpet fibers porosity water permeability kevlar hpet pet hybrid geotextile decrease
manufacturing engineering locating error analysis workpieces common issue predicting quality machined features computer aided fixture design tolerance allocation article presents locating error analysis approach workpiece general fixture layouts parameterized tolerances initially fixture transformed six locating points space linearized model derived convey relationship errors locating points locating errors using implicit differentiation first order taylor expansion tolerances features plane cylinder free form surface parameterized using homogeneous transformation matrices finally two formulas derived calculate errors locating points surface surface mating hole pin mating two workpieces presented demonstrate validate proposed method relative errors results calculated proposed method results calculated dcs less
well known variable step size least mean square vsslms algorithm provides faster convergence rate maintaining lower mean square error conventional lms algorithm performance vsslms algorithm improved channel estimation problem impulse response channel sparse recently zero attracting vsslms algorithm proposed exploit sparsity channel done imposing norm penalty original cost function vsslms algorithm utilizes sparsity filter taps adaptation process paper present mean square deviation msd analysis vsslms algorithm steady state msd expression vsslms algorithm derived upper bound zero attractor controller provides minimum msd also provided moreover effect noise distribution msd performance shown theoretically shown theoretical simulation results algorithm good agreement wide range parameters different channel input signal noise types
contrast induced nephropathy cin iatrogenic acute renal failure occurring following intravascular injection iodinated radiographic contrast medium however regulatory mechanisms cin remain fully elucidated present study aimed investigate whether atorvastatin protects cin via anti apoptotic effects upregulation hsp vivo vitro determine whether atorvastatin attenuated cin inflammatory response apoptosis vivo vitro rat model iopamidol induced cin used human embryonic proximal tubule cell damage assessed rats assigned four groups per group follows control rats rats atorvastatin rats iopamidol rats iopamidol atorvastatin vitro cells treated iopamidol presence absence atorvastatin heat shock protein hsp small interfering rna pcdna hsp renal tissues examined histopathologically collected western blot analysis results showed atorvastatin ameliorated apoptosis deterioration renal function furthermore atorvastatin reduced iopamidol induced activity cell lymphoma bcl associated protein bax caspase increased expression bcl vivo vitro notably following treatment hsp sirna pcdna hsp found iopamidol enhanced weakened upregulation bax caspase downregulation bcl cells respectively results present study suggested atorvastatin protected contrast induced renal tubular cell apoptosis upregulation hsp vivo vitro
loss dopaminergic neurons resultant motor impairment hallmarks parkinson disease syy cell line model dopaminergic neurons allows study dopaminergic neuronal injury previous studies revealed changes ethe eag potassium channel expression induced syy apoptosis regulatory involvement microrna mir demonstrated present study involvement eag mir rotenone induced syy cell injury investigated rotenone neurotoxin often used generate models parkinson disease since causes death nigrostriatal neurons inducing intracellular aggregation alpha synuclein ubiquitin present study rotenone resulted dose dependent decrease cell viability revealed dimethylthiazol diphenyltetrazolium bromide mtt trypan blue cell counting assays addition eag demonstrated constitutively expressed syy cells involved cell viability suppression eag astemizole resulted dose dependent decrease cell viability revealed mtt assay astemizole also enhanced severity rotenone induced injury syy cells rna interference eag using synthetic small interfering rnas sirnas corroborated finding sirnas potentiated rotenone induced injury eag targeted sirnas eaghum resulted statistically significant increase vulnerability rotenone increased number apoptotic nuclei observed cells transfected eaghum notably sirna intensified rotenone induced apoptosis revealed increase caspase activity conversely mir inhibitor demonstrated exert neuroprotective effects viability cells exposed rotenone treated mir inhibitor restored conclusion eag potassium channels mir involved response rotenone induced injury syy cells neuroprotective effect mir inhibitors merits investigations animal models parkinson disease
circumvent scaling relations activation energies adsorption energies catalytic surfaces limiting catalytic activity perovskites investigated solar driven production ammonia via two step redox cycle cycle consists endothermal reduction degrees using solar process heat followed exothermal hydrolysis forming degrees steps carried ambient pressure electronic structure computations employed assess stability surface activity oxygen vacancies lattice nitrogen facet nitrogen doped perovskites results compared activities mon mon mnn reference models find producing oxygen vacancies high temperature active reduction energetically limiting reaction step redox cycle redox energetics tuned perovskite composition sensitive type transition metal site terminating surface promising perovskites contain surface doped bulk cacoo terminated srcoo terminated camno terminated mno trade offs redox energetics quantified guide future experimental work authors published elsevier
systems polynomial equations arise throughout mathematics engineering sciences therefore fundamental problem mathematics application areas find solution sets polynomial systems focus paper compare two fundamentally different approaches computing representing solutions polynomial systems numerical homotopy continuation symbolic computation several illustrative examples considered using software packages bertini singular elsevier inc rights reserved
contact structure asphalt mixtures considered important micromechanical mixture property related rutting performance study two dimensional image acquisition processing procedure utilized acquire contact structure asphalt mixtures varying compactness gradation types nominal maximum aggregate sizes nmas binder types new indices contact structure different asphalt mixtures developed based three aspects contact distance distribution contact length distribution contact orientation including average contact distance ave proportion contact distance proportion contact distance total contact length sum number contact contact average contact length ave average contact angle inclination vector magnitude delta flow number strain rate dynamic creep test determined rutting indicators varying asphalt mixtures linear regression model used investigate relationship new contact indices rutting indicators results indicated contact structure varying mixtures could successfully differed new indices proposed new indices sum ave ave could ranked similar trend flow number furthermore comprehensive index represented contact structure asphalt mixtures developed better uncover mechanism rutting micromechanical perspective published elsevier ltd
labor productivity significant impact time cost quality construction project especially competitive environment construction industry forces construction companies increase labor productivity values order keep positions industry respect identification evaluation factors affect labor productivity becomes crucial issue industrial practitioners academic literature many studies investigated factors relationships labor productivity studies factors categorized different groups ranked according importance levels however studies standard deviation among factors group mean value group neglected addition perspectives managers taken account general craft workers ignored aim current study evaluate factors groups considering standard deviations mean values craft workers point view purpose detailed literature review factors identified categorized four groups organizational economical physical socio physiological factors questionnaire survey applied craft workers obtain necessary data analyzed means relative importance index rii technique results revealed although ranking factors remained importance levels changed authors published elsevier ltd
echo state network esn based learning method developed optimal energy management office solar energy introduced renewable source battery installed control unit energy consumption office also considered energy demand separated sockets lights air conditioners first esns well known excellent modelling performance time series employed model time series real time electricity rate renewable energy energy demand periodic functions second given periodic models electricity rate renewable energy energy demand esn based learning method function approximated esn developed implemented determine optimal charging discharging idle strategies battery office total cost electricity grid reduced finally numerical analysis conducted illustrate performance developed method
introductionthis study examined relationships changes symptoms changes quality life qol cognitive behavioral therapy cbt panic disorder methodswe treated patients group cbt japan using multiple regression analysis examined associations changes qol changes symptoms comorbid psychological symptoms cbt resultschanges anticipatory anxiety agoraphobic fear avoidance somatization significant predictors changes aspects qol discussionit might useful decrease somatization anticipatory anxiety agoraphobic fear improve qol cbt
paper presents fieldwork control system studies examine improve thermal comfort occupants typical office building malaysia proposed control system works basis adjusting thermostat setting certain period time degree using fuzzy logic thermostat central system set point fixed slightly range recommended malaysian standard order maintain room comfort occupants choose switch central system certain period time switched back repeated least per working days therefore proposed control system designed overcome practice pre post comfort surveys conducted thermal comfort level occupants throughout study investigated air temperature globe temperature air velocity relative humidity occupied area data logged continuous five working days data used compute operative temperature new thermostat set points generated indicates possible adjustment recommended set point proposed thermostat setting error tolerance less result simulation results show adjustment thermostat setting successfully maintained room temperature main office relative humidity maintained also outcomes indirectly promoted average increase thermal comfort satisfactory level occupants practical application new conclusions simplified thermostat control strategy customised according environment variables air conditioned space case operative temperature relative humidity based preferences occupants level thermal comfort suits current thermal environment tropical climates could applied important guide building services engineers researchers aims reduce energy usage hvac systems non green office buildings tropical climates maintaining adequate thermal comfort level thus performance well office workers improved
paper ultra broadband polarization insensitive terahertz thz metamaterial absorber presented investigated optimization structural parameters resonant peaks merged broadband absorption spectrum simulation results demonstrate wide bandwidth thz obtained range thz absorption higher normal incident thz waves full width half maximum fwhm absorption spectrum respect central frequency similar thz five times greater fwhm single layer structure furthermore structure keep absorption large frequency range thz incident angle smaller degrees metamaterial absorber find potential applications terahertz imaging stealth technology crown copyright published elsevier rights reserved
introduction students universities mostly live independently parents guardians first time gives freedom opportunity high risk behavior unplanned unprotected sex results sexual experimentation may include unplanned unwanted pregnancies may lead unsafe abortions sexually transmitted infections stis including hiv aids contraception potential prevent unwanted pregnancies abortion stis study aimed assessing general knowledge contraceptives sexual practices level utilization contraceptives devices among unmarried students bayero university kano methods institutional based cross sectional descriptive study administered pretested self administered structured questionnaire randomly selected unmarried undergraduate students institution analyzed data using microsoft excel epi info results total students interviewed median age respondents years age range years male respondents made females made remaining also respondents lived outside school campus lived school hostels knowledge contraception among respondents internet media commonest sources knowledge proportion sexually active students prevalence contraceptive utilization among sexually active students sexual debut years age ages years years age sexually active respondents practice vaginal sex sexual debuts planned friends occurred ages years age group respondents conclusion even though knowledge contraceptive used high among respondents utilization contraceptives among sexually active students low thus creating window possible unintended unwanted pregnancies among group students
background drug related movement disorders drmds reduce quality life contribute medication noncompliance patients psychotic disorders little known epidemiology drmds relatively young patients years onset psychosis important period study impact antipsychotic treatment long term potentiation neural pathways associated psychotic disorders drmds still minimal study investigated prevalence incidence persistence clinical correlates drmds patients first years disease onset methods genetic risk outcome psychosis study longitudinal study relatively young patients nonaffective psychosis mean age illness duration years respectively following drug related movement disorders assessed baseline year follow parkinsonism akathisia tardive dyskinesia tardive dystonia determined prevalence incidence persistence investigated clinical correlates baseline follow assessment results patients mean age illness duration baseline years respectively patients developed drmd year study period prevalence incidence persistence rates highest parkinsonism followed akathisia tardive dyskinesia significant associations found drmds patients age psychopathology conclusions prevalence persistence incidence drmds sample high despite relatively young age recent onset disorder treatment primarily second generation antipsychotics findings emphasize screening diagnosis treatment drmds still important
paper presents fully integrated wireless bondwire accelerometer using closed loop readout interface effectively reduces noise electrical circuits long term frequency drifts proposed accelerometer fabricated using cmos technology without micro electromechanical systems mems processing reduce manufacturing errors bondwire inertial sensors wire bonded chip pads thereby enabling precisely defined length space sensing bondwires proposed wireless accelerometer using pair bondwires achieves linear transducer gain bandwidth khz noise floor root bias stability acceleration data digitalized energy efficient bit sar adc wirelessly transmitted real time external reader low power shift keying ook transmitter proposed architecture consumes chip area
similarity search important fundamental problem thus widely used various fields computer science including multimedia computer vision database information retrieval etc recently since loitering behavior often leads abnormal situations pick pocketing terrorist attacks analysis attracts increasing attention research communities paper present antiloiter loitering discovery system adopting efficient similarity search surveillance videos know existing systems loitering analysis mainly focus detect identify loiterers behavior tracking techniques however difficulties tracking based methods known analysis results heavily influenced occlusions overlaps shadows moreover tracking based methods need track human appearance continuously therefore existing methods readily applied real world surveillance cameras due appearance discontinuity criminal loiterers solve problem abandon tracking method instead propose antiloiter efficiently discover loiterers based frequent appearance patterns longtime multiple surveillance videos antiloiter propose novel data structure luigi indexes data using similarity value returned corresponding function face matching luigi adopted perform efficient similarity search realize loitering discovery conducted extensive experiments synthetic real surveillance videos evaluate efficiency efficacy approach experimental results show system find loitering candidates correctly outperforms existing method times terms runtime
considering one past prosociality affect future behavior prior research revealed instances adults engage additional prosocial behavior moral reinforcement well instances adults engage worse behavior moral licensing current study examined developmental origins effects testing whether year old children less generous recalling good deeds children asked recount time nice mean watched movie children behaved generously recalling time nice show boost generosity simply result instructing children consider nice behavior children giving increase recalling others good deeds also show even recounting multiple instances past goodness children continue behave generously findings suggest good leads good children elsevier inc rights reserved
nonverbal communication integral element classroom teachers pedagogy whether accompanying extending replacing verbal nonverbal communication holds potential dramatically influence classroom environment essay explores classroom instructors nonverbal communication behaviors associated immediacy may understood important factors engendering positive supportive learning environment
internet addiction condition characterized loss control internet use leading variety negative psychosocial consequences recent neuroimaging studies begun identify related changes specific brain regions connections however whether interactions within large scale brain networks disrupted individuals remain largely unexplored using group independent component analysis extracted five intrinsic connectivity networks icns resting state fmri data adolescents controls including anterior posterior default mode network dmn left right fronto parietal network fpn salience network examined possible group differences functional connectivity within icn icns found compared controls subjects showed reduced inter hemispheric functional connectivity right fpn whereas increased intra hemispheric functional connectivity left fpn reduced functional connectivity dorsal medial prefrontal cortex mpfc anterior dmn reduced functional connectivity anterior dmn findings suggest associated imbalanced interactions among dmn fpn may serve system level neural underpinnings uncontrollable internet using behaviors elsevier ltd rights reserved
constrict claim ethnic heterogeneity drives social trust empirically tested across globe meta analyses suggest neighbourhood ethnic heterogeneity generally undermines ties within neighbourhood trust neighbours concurrently inconsistent even positive effect interethnic ties outgroup trust composition living environment thus often seems matter remain unclear contribute literature scrutinizing extent ethnic heterogeneity drives trust coethnic neighbours non coethnic neighbours unknown neighbours unknown non neighbours similarly comparing effects heterogeneity aggregated geographical areas vary scale type boundary assessing whether impact heterogeneity local area depends wider geographic context test hypotheses religion dutch society dataset supplemented uniquely detailed gis data statistics netherlands dependent variables four different called wallet items model spatial multilevel regression techniques demonstrate trust non coethnic coethnic neighbours lower heterogeneous environments trust people outside neighbourhood affected local heterogeneity measures heterogeneity aggregated relatively large scales administrative municipalities egohoods radius demonstrate strongest negative relationships trust indicators
consider flow systems utilized small scale biomolecular computing digital signal processing binary operating biosensors signal measurement optimized designing flow reversal cuvette analyzing experimental data theoretically extract pulse shape well reveal level noise possesses noise reduction carried numerically conclude accomplished physically via addition properly designed well mixing flow reversal cell integral part flow system approach enable improved networking capabilities potentially digital analog signal processing systems possible applications complex biocomputing networks various sense act systems discussed
background given strong environmental influence epigenetic marks allergic asthma children epigenetic alterations respiratory epithelia might provide insight allergic asthma objective sought identify dna methylation gene expression changes associated childhood allergic persistent asthma methods compared genomic dna methylation patterns gene expression african american children persistent atopic asthma versus healthy control subjects results validated independent population asthmatic children using shared healthy control population independent population white adult atopic asthmatic patients control subjects results identified genes significant methylation changes differentially methylated regions differentially methylated probes adjustment age sex race ethnicity batch effects inflation multiple comparisons genes differentially methylated included established roles asthma atopy genes related extracellular matrix immunity cell adhesion epigenetic regulation airflow obstruction methylation changes substantial median range hypomethylated hypermethylated genes associated increased decreased gene expression respectively differentially methylated regions differentially methylated probes quantitative analysis differentially expressed genes demonstrated significant methylation expression relationships within gene ten loci selected based relevance asthma magnitude methylation change methylation expression relationships validated independent cohort children atopic asthma sixty seven genes also significant asthma associated methylation changes nasal epithelia adult white asthmatic patients conclusions epigenetic marks respiratory epithelia associated allergic asthma gene expression changes inner city children
background committee economic social cultural rights states right health closely related dependent upon realization human rights including right food water education shelter important determinants health children healthcare workers low income settings may spend majority professional lives trying mitigate deficiencies rights little influence order advocate successfully local level aware proportion children living catchment population access basic rights order carry rights audit framework within healthcare workers could play part required agreed minimum core rights timeframe set indicators discussion framework assess well states developmental partners adhering human rights principles discussed including role healthcare worker might optimally play minimum core economic social rights seeks establish legal minimum set protections available immediate effect applicable nations despite different resources minimum core rights impact progressive realisation may right health discussed including include perspective children health set absolute rights suggested based physiological needs aligned corresponding articles united nations convention rights child development indicators likely used monitor progress towards sustainable development goals suggested way monitor rights consider ways healthcare worker could use rights audit advocate community summary audits could achieve several objectives may legitimise healthcare workers interests determinants health often highly respected community may facilitate agents change local level may raise awareness basic human rights importance health contribute needed change mind set one development needs absolute rights results may catalyse colleagues analyse upstream reasons children families live rights met
paper proposes autonomous system identification methodology fixed wing autonomous aerial vehicles aavs implementation robust control technique system identification methodology require user provide knowledge aerodynamic derivatives aav hence control methodology applicable wide range fixed wing aavs since system identification process generates errors due measurement noise external disturbances robust control methodology slidingmode control smc proposed control aav based system identification results characterize capability control methodology experiments conducted commercially available fixed wing aircraft platforms using low cost sensing equipment experimental results demonstrate autonomous system identification based smc enables aav follow desired trajectory without prior knowledge aerial vehicle manual tuning control system parameters
paper reports results action research conducted outreach program aimed introducing secondary school students exciting world computer programming key challenges introduce programming problem solving session done short time within hours fun way achieved using physical mobile robot called robokar engage students problem solving activities involving programming entry exit surveys facilitators observations concluded robot platform outreach program able introduce spark interest learning programming among school students
directly perturbed healthy subjects premotor cortical areas generate electrical oscillations beta range schizophrenia major depressive disorder bipolar disorder oscillations markedly reduced terms amplitude frequency however still remains unclear whether abnormalities modulated time still observed treatment employed transcranial magnetic stimulation tms combined eeg assess frontal oscillatory activity eighteen patients antidepressant treatments sleep deprivation light therapy relative nine healthy controls order detect dominant frequencies event related spectral perturbations ersp computed tms eeg session participants using wavelet decomposition natural frequency cortical circuit oscillates calculated frequency value largest power across post stimulus time interval severity depression markedly decreased treatment patients achieving response nine patients achieving remission tms eeg resulted significant activation beta gamma band response healthy controls patients main frequencies premotor eeg responses tms significantly change treatment always significantly lower controls comparable patients achieving remission responding treatment results suggest reduction natural frequencies trait marker independent clinical status patients present findings shed light neurobiological underpinning severe psychiatric disorders demonstrate tms eeg represents unique tool develop biomarkers psychiatry elsevier masson sas rights reserved
secure safe authentication vehicular hoc network vanet essential network security safe data transmission requires integrity availability privacy protection features well efficient communication diverse settings recently proposed security protocols vehicular communication authenticate complex way areas heavy traffic due increasing number messages proportion number vehicles efficient communication data volume need reduced communication safe range attacks hence present paper proposes protocol accelerates message processing sending low data volume communication areas heavy traffic blocks replay attacks checking timestamps addition casper fdr lowe casper compiler analysis security protocols user manual tutorial version formal systems europe ltd failures divergence renement fdr user manual used verify proposed protocol security efficiency security vulnerabilities
unsymmetric laminated plate considered coupling plane plate bending problems unavoidable boundary element coupled stretching bending analysis developed previously suitable complex form fundamental solution usually singular integrals involved boundary element treated conventional methods gaussian quadrature rule regular functions logarithmic gaussian quadrature formulas function logarithmic terms use finite part integrals evaluation sense cauchy principal value calculated indirectly employment rigid body movement avoid complexity numerical integration complex form fundamental solution paper provide explicit closed form solutions singular integrals simplify computer programming expedite numerical computation hence accuracy efficiency associated boundary elements improved newly derived analytical solutions elsevier ltd rights reserved
aimsa longitudinal birth cohort provides opportunity study impact childhood conditions persisting adulthood study examines cross sectional association asthma sleep quality snoring adolescent young adult population extent asthma sleep quality snoring years independently predict years methodsdata year follow mothers children recruited mater university queensland study pregnancy complete asthma sleep information questionnaire data available participants years years participants years resultspoor sleep quality snoring independently associated asthma years years stronger associations evident women years associations mediated asthma symptom severity asthma sleep quality snoring years strongly independently predicted years asthma years predicted snoring years poor sleep quality snoring women predicted asthma years latter partially mediated body mass index conclusionsthe relationship asthma sleep quality snoring varied gender sleep quality snoring considered assessment holistic management asthma predictive relationship seen years provides opportunity address issues younger age
objective examine male female differences pediatric overuse sports injuries study design cross sectional epidemiological study setting tertiary level sports medicine division large academic pediatric medical center participants five percent probability sample patients years seen january december charts reviewed final study cohort included patients intervention nonlinear decomposition analysis male female differences overuse injuries main outcome measures age body mass index history previous injury activity type contact collision team individual high overuse results females sustained approximately half total injuries fifty two percent injuries overuse lower extremity high proportion tennis players swimmers dancers track athletes runners gymnasts cheerleaders seen overuse injuries females sustained overuse injuries versus males respectively males playing team sports times higher likelihood seen overuse injury compared males playing team sports high overuse sport participation increased overuse injury odds factor males versus females males females forty six percent male female difference overuse injuries could attributed sport activity characteristics contact collision team high overuse conclusions large proportion sex discrepancy overuse injuries cohort attributed compositional differences sports played future research needed investigate independent effect sex risk pediatric sports injuries clinical relevance study provides unique analysis male female differences pediatric sports injuries first study estimate impact different characteristics collision team high overuse sports children play overuse injuries sustained young athletes findings help guide future prevention efforts
weight loss gas release behavior mengdong coal pyrolysis investigated using thermogravimetric analyzer coupled fourier transform infrared spectroscopy tga ftir char evolution coal chars derived different pyrolysis temperature analyzed two dimensional perturbation correlation infrared spectroscopy pcis method reveal mechanism mengdong coal pyrolysis coal showed significant weight loss degrees pyrolysis free groups reacted nand self associated mers hydrogen bond demethylenation reaction sequence aliphatic groups asymmetric aliphatic symmetric aliphatic asymmetric aliphatic releasing mainly resulted crack aryl ethers groups alcohols coal molecular effect kco char structure also studied results showed inherent mineral coal presented stronger catalytic effects towards pyrolysis kco addition influenced reaction sequences symmetric asymmetric insignificantly could significantly change correlation aromatic bond elsevier rights reserved
zonisamide zns anticonvulsant drug exhibiting symptomatic effects parkinson disease recently reported exert neuroprotection rodent models one proposed neuroprotective mechanisms involves increased protein expression xct specific subunit cystine glutamate antiporter system inducing glutathione gsh synthesis investigated outcome zns treatment mouse model based intranigral proteasome inhibition whether observed effects would mediated system proteasome inhibitor lactacystin lac administered intranigrally male cbl mice receiving repeated intraperitoneal injections either zns vehicle drug administration initiated three days prior stereotaxic lac injection maintained six days post surgery one week lesion mice behaviorally assessed investigated terms nigrostriatal neurodegeneration molecular changes level basal ganglia including expression levels xct zns reduced loss nigral dopaminergic neurons following lac injection degree sensorimotor impairment zns failed however modulate xct expression basal ganglia lesioned mice separate set experiments impact zns treatment system investigated control conditions vivo well vitro similarly zns influence xct glutathione levels naive male cbl mice alter system activity glutathione content vitro taken together results demonstrate zns treatment provides neuroprotection behavioral improvement mouse model based proteasome inhibition via system independent mechanisms elsevier inc rights reserved
let set scalar functions form satisfy natural properties describe subdivision algorithm computing clustered epsilon isotopic approximation minimization diagram exploiting soft predicates clustering voronoi vertices algorithm first handle arbitrary degeneracies allow scalar functions piecewise smooth necessarily semi algebraic apply ideas computation anisotropic voronoi diagram polygonal sets natural generalization anisotropic voronoi diagrams point sites extends multiplicatively weighted voronoi diagrams implement prototype anisotropic algorithm provide experimental results
construction site induced water pollution could negatively affect environment well economic social well people underlying problem initiated study current management approach segregates mitigation based site water pollution practices construction planning consequently isolating production environmental variable study intents improve current practice integrating site water pollution practices construction planning grounding prevention based concepts order simultaneously address production environmental aspects construction exploratory nature study warrant use research methods involve systematic review integrative literature review also verification semi structured interview industry players research findings suggest distinctive elements site water pollution preventive practices construction planning schedule method site layout could integrated applied simultaneously construction schedule found prominent element established integration initial target practical implementation framework study pioneer work acts bridge connects practical industry aspects preventing site water pollution linkage construction planning elements consequently findings study fills gap knowledge sectors would enable concurrent management production environmental dimensions construction elsevier ltd rights reserved
research documents exposure adversity childhood leads negative health outcomes across lifespan less known protective factors aspects individual family community promote good health despite exposure adversity guided resilience portfolio model study examined protective factors associated physical health sample adolescents adults exposed high levels adversity including child abuse rural community sample individuals average age participated surveys via computer assisted software participants completed self report measures physical health adversity range protective factors drawn research resilience participants reporting greater burden childhood victimization current financial strain adverse life events poorer physical health strengths emotion regulation meaning making community support social support practicing forgiveness reported better health hypothesized strengths across resilience portfolio domains regulatory meaning making interpersonal independent positive associations health related quality life accounting participants exposure adversity prevention intervention efforts child maltreatment focus bolstering portfolio strengths foundation work needs begin families early lifespan elsevier ltd rights reserved
microwave processed xmgfeo characterized fordc conductivities dielectric properties function temperature frequency low dielectric loss tangent achieved mhz frequency grain grain boundary contribution towards conductivity presented basis nyquist plots resistances evaluated semi circular arcs equivalent electrical circuits approximate values presented better insight high dielectric constant sampleinstigated possibility good electromagnetic absorption material shift transport phenomenon suggested band like polaron hopping rise temperature addition electromagnetic interference shielding properties studied band results show goodelectromagnetic interference shielding efficiency achieved compositions ranging ghz suitable shielding application elsevier ltd rights reserved
enhance storage life post storage quality fresh goji berries three treatments lecithin two storage times days evaluated significant effects physiological biochemical parameters varied lecithin showed main effects days storage reduction total weight loss decay ssc ratio also days chlorophyll content highest scores sensory attributes also days lecithin showed main effects days storage highest ssc highest also days highest tpc significant reduction dpph antioxidant activity highest total flavonoid content lecithin showed main effects days storage highest ssc chlorophyll content total flavonoid dpph abts antioxidant activity also days least scores sensory attributes elsevier ltd rights reserved
improve flexibility robustness engineering automated production systems aps case extending reducing modifying parts several approaches propose encapsulation clustering related functions electrical mechanical software engineering based modular architecture considering development modules different stages module planning functional engineering completed reference model addresses different stages engineering aps proposed automation markup language aml due different stages integration several engineering disciplines mechanical electrical electronic software engineering information limited one discipline stored redundantly increasing effort transfer information risk inconsistency although data formats storage exchange plant engineering information exist aml fixed domain specific structures relations information automated material flow systems amfss missing paper presents integration metamodel development modules amfs improve transferability consistency information different engineering stages increasing level detail coarse grained plant planning fine grained functional engineering note practitioners engineering automated production systems apss highly interdisciplinary procedure requires interaction participating people however communication engineering process based exchange information orally documents addition many influences different design stages time periods cause change parts parameters hence neighboring engineering disciplines employ data need updated regarding changes consequently one challenge engineering aps data exchange well guarantee consistent complete description system contribution presents methodology data exchange different tools applied engineering cycle design process aps therefore reference process proposed automation markup language associated data model data exchange applied contrast current state art approach additionally proposes integration metamodel aps order identify engineering data required complete description
objective objective study examine independent association emotional distress unhealthy sleep duration defined hours methods data national health interview survey nhis cross sectional household survey analyzed investigate associations emotional distress unhealthy sleep durations adjusting sociodemographic factors health risks chronic diseases hierarchical multiple logistic regression analysis participants total participants age range years nhis dataset interviewed measures unhealthy sleep duration defined sleep duration hours whereas healthy sleep defined sleep duration lasting hours emotional distress based kessler non specific distress battery assesses frequency feeling sad nervous restless hopeless worthless burdened day period results sample female white black eleven percent experienced emotional distress reported unhealthy sleep adjusted logistic regression analysis revealed individuals emotional distress greater odds reporting unhealthy sleep odds ratio confidence interval conclusion emotional distress important proxy poor psychological health significant predictor unhealthy sleep independent influences several factors including demographic age education sex race ethnicity family income health risks alcohol consumption smoking status chronic diseases conditions diabetes obesity hypertension heart disease cancer arthritis
thrombin essential component coagulation cascade participates pathogenesis brain diseases ischemic stroke intracerebral hemorrhage alzheimer disease parkinson disease blood brain barrier bbb dysfunction thought thrombin matrix metalloproteinase mmp axis important process pathogenesis neurovascular disease bbb dysfunction recently reported brain pericytes mmp releasing cells response thrombin stimulation among bbb constituting cells thrombin induced mmp release partially due protease activated receptor par one specific thrombin receptors evaluated intracellular signaling pathways involved mmp release contribution thrombin reactive brain pericytes bbb dysfunction pkc activator evoked mmp release brain pericytes thrombin induced mmp release inhibited however decreased phosphorylation levels pkc theta akt decreased phosphorylation levels pkc delta extracellular signal regulated kinase erk additionally treatment pericytes thrombin par activating peptide stimulated pkc delta theta signaling substances impaired brain endothelial barrier function presence brain pericytes brain pericytes function two independent downstream signaling pathways via par activation release mmp response thrombin pkc theta akt pathway pkc delta erk pathway pathways participate par mediated mmp release pericytes leads bbb dysfunction brain pericytes specific signaling pathways could provide novel therapeutic targets thrombin induced neurovascular diseases ibro published elsevier ltd rights reserved
lipids play central role lung physiology pathology however comprehensive lipidomic characterization human pulmonary cells relevant disease performed cells involved lung host defense including alveolar macrophages ams bronchial epithelial cells becs alveolar type cells atiis isolated human subjects lipidomic analysis performed additionally pieces lung tissue donors analyzed maldi imaging order determine lipid localization tissue unique distribution phospholipids atiis becs ams human subjects accomplished subjecting large number identified phospholipid molecular species univariant statistical analysis specific maldi images generated based univariant statistical analysis data reveal location specific cell types within human lung slice jlr complex composition function lipidome various disease states currently poorly understood method could useful characterization lipid alterations pulmonary disease may aid better understanding disease pathogenesis
building detection two dimensional highresolution satellite images computer vision photogrammetry remote sensing task arisen last decades advances sensors technology utilized several applications require creation urban maps study urban changes however variety irrelevant objects appear urban environment resemble buildings significant variations shape generally appearance buildings render building detection quite demanding task result automated methods robustly detect buildings satellite images necessary end propose building detection method consists two modules first module feature detector extracts histograms oriented gradients hog local binary patterns lbp image regions using novel approach support vector machine classifier trained introduction special denoising distancemeasure computation distances hog lbp descriptors classification building nonbuilding class second module consists set region refinement processes employs output hog lbp detector form detected rectangular image regions image segmentation performed novel building recognition methodology proposed accurately identify building regions simultaneously discard false detections first module proposed method demonstrate proposed methodology robustly detect buildings satellite images outperforms state art building detection methods
product portfolio diversity prominent customers critical manufacturers manufacturers perspective diversity must maintained level engineering costs exceed acquired advantages increased market share therefore paper consider problem product portfolio planning simultaneously maximise market share minimise manufacturing engineering costs since problem belongs hard class problems exact algorithms incapable rendering optimal solution therefore used metaheuristic based simulated annealing deal problem proposed algorithm consists two parts random search predetermined rule generate next possible neighbours product portfolio order robust algorithm calibrated different levels problem parameters using taguchi method method picks best levels different parameters conducting least possible experiments evaluate performance proposed algorithm compared strong algorithm genetic algorithm used comparison basis research obtained computational results clearly demonstrate efficiency effectiveness proposed algorithm
muscle activity growth considerably important mandible quality morphology reducing dietary loading directly influences development metabolic activity mandibular condylar cartilage mcc however overall investigation changes protein composition mcc fully described literature study protein expression putative signaling vivo evaluated structural changes mcc differentially expressed proteins induced reducing functional loading rat mcc developmental stages isobaric tag relative absolute quantitation based nano high performance liquid chromatography hplc matrix assisted laser desorption ionization time flight time flight maldi tof tof technologies used global protein profiling kegg panther pathways functional categories analyzed consequently histological tartrate resistant acid phosphatase staining indicated altered histological structure condylar cartilage increased bone remodeling activity hard diet group total differentially expressed proteins identified analysis revealed significant number proteins involved metabolic process cellular process biological regulation localization developmental process response stimulus kegg pathway analysis also suggested proteins participated various signaling pathways including calcium signaling pathway gap junction erbb signaling pathway mitogen activated protein kinase signaling pathway collagen types validated immunohistochemical staining western blot analysis taken together present study provides insight molecular mechanism regulating condylar growth remodeling induced reducing dietary loading protein level
background becoming increasingly common individuals organizations use social media platforms facebook used wide variety purposes including disseminating discussing seeking health related information federal health agencies leveraging platforms engage social media users read spread promote encourage health related discussions however different agencies communications get varying levels engagement study use statistical models identify factors associate engagement methods analyze facebook posts facebook accounts belonging health agencies account usage user activity sentiment content posts studied use hurdle regression model identify factors associated level engagement cox proportional hazards model identify factors associated duration engagement results analysis find agencies accounts vary widely usage social media activity generate statistical analysis shows instance facebook posts visual cues photos videos express positive sentiment generate engagement find posts certain topics occupation organizations negatively affect duration engagement conclusions present first comprehensive analyses engagement federal health agencies facebook addition briefly compare contrast findings study earlier study similar focus twitter show robustness methods
introduction prior studies reported association sexual dysfunction pelvic floor dysfunction pfd without defining causation aim investigate predictors sexual function women pfd including pelvic organ prolapse stress urinary incontinence overactive bladder obstructed defecation fecal incontinence methods retrospective cross sectional study included women mean age years postmenopausal referred pfd subjects underwent standardized history examination including demographics assessment pelvic floor function sexual function using validated quality life instruments physical examination included body mass index pelvic organ prolapse quantification measurements pelvic muscle strength oxford scale proportional odds regression analysis tested patient characteristics pfd determinants sexual dysfunction predictors sexual function main outcome measures pelvic floor distress inventory pfdi pelvic floor impact questionnaire pfiq assess pfd short personal experiences questionnaire assess sexual function results prevalence pfd included pelvic organ prolapse stress urinary incontinence overactive bladder fecal incontinence obstructed defecation subjects sexual partner reported recent sexual intercourse participants reported low level sexual desire sexual enjoyment moderate levels sexual arousal orgasm stratified sexual enjoyment enjoyed sex group lower pfdi pfiq scores reflecting less quality life burden pelvic organ prolapse obstructed defecation fecal incontinence associated enjoying sex however adjusted determinants sexual dysfunction aging dyspareunia atrophy partner issues associations disappeared conclusion women pfd also large burden sexual dysfunction although appears mediated factors unique pfd copyright international society sexual medicine published elsevier inc rights reserved
hall sensors analog output used rotational speed sensors provided angular position reference diagnostics measurements cryogenic propellant electric pump pep test campaign frictionless foil bearing important technology needs well characterized tests tested pep hall sensor outputs helped process signals eddy current radial axial shaft displacement sensors piezoelectric vibration sensors hall sensor signal also used main motor speed feedback signal test bench control system
paper efficient analysis method considering geometric material nonlinearities proposed predicting ultimate strength behavior multi span suspension bridges geometric nonlinearities cable members due sag effects captured using catenary element geometric nonlinearities beam column members due second order effects captured using stability functions material nonlinearities cable beam column members considered using elastic plastic hinge refined plastic hinge models respectively simple initial shape analysis method presented determine deformed shape initial cable tension bridge dead loads numerical examples presented verify accuracy efficiency proposed method addition case study four span suspension bridge carried show capability proposed method estimating strength behavior large scale structures elsevier ltd rights reserved
explore shape changing clevaging nature anti kink solutions dimensional type kadomtsev petviashvili equation achieved invoking multiple exp function method aided symbolic computation remains indispensable tool deal computational algebraic systems
thermoacoustic instability serious issue practical combustion systems systems inherently noisy hence influence noise dynamics thermoacoustic instability aspect practical importance present work motivated recent report experimental observation coherence resonance noise induced coherence resonance like dependence noise intensity system approaches stability margin prototypical premixed laminar flame combustor kabiraj phys rev numerically investigate representative thermoacoustic models noise induced dynamics similar experiments study variation system dynamics response variations noise intensity critical control parameter systems approach stability margins qualitative match identified experimental results observations representative models investigated confirms coherence resonance feature thermoacoustic systems also extend experimental results limited case subcritical hopf bifurcation case supercritical hopf bifurcation identify phenomenon qualitative differences systems undergoing transition via subcritical supercritical hopf bifurcations two important practical implications associated findings firstly increase noise induced coherence system approaches onset thermoacoustic instability considered precursor instability secondly dependence noise induced dynamics bifurcation type utilised distinguish subcritical supercritical bifurcation prior onset instability elsevier ltd rights reserved
lack existing studies fatigue testing interlaminar anticracking materials study analyzes principle generating reflective cracks using three types composite specimens direct overlay asphalt mixture layer repaving impregnated nonwoven geotextile layer repaving anticracking material layer study proposes method laboratory fatigue testing observing reflective cracks specimens used bending fatigue test centric load shear fatigue test eccentric load test results analyzed regression analyses showed anticracking material layer much better crack resistance direct overlay asphalt mixture layer repaving impregnated nonwoven geotextiles layer anticracking material layer could absorb bending shear stresses near cracks efficiently delay generation expansion reflective cracks study used reference make reasonable selection interlaminar anticracking material rigid flexible composite pavements american society civil engineers
work presents software system designed track reproduction musical piece aim match score position symbolic representation digital sheet system known automated musical accompaniment system process score alignment carried real time real time score alignment also known score following poses important challenge due large amount computation needed process digital frame small time slot process moreover challenge even greater since interested handheld devices devices characterized low power consumption mobility results presented show possible exploit efficiently several cores arm processor gpu accelerator presented socs nvidia reducing processing time per frame cases
paper introduces novel approach providing high school students access computer science experiences part algebra unit linear functions approach developed tested part funded national science foundation study unit piloted study integrates computational thinking computer modeling project based algebra unit linear functions literature computational thinking access computer science secondary settings modeling approaches project based learning design based research described provide rationale study design ultimate goal study develop paradigm integrating computer science experiences algebra way increase engagement stem computing among students backgrounds
enterococcus faecalis gram positive bacterium candida albicans fungus occupy overlapping niches ubiquitous constituents gastrointestinal oral microbiome species also among important problematic opportunistic nosocomial pathogens surprisingly two species antagonize virulence nematode infection vitro biofilm models report identification faecalis bacteriocin entv produced entv locus necessary sufficient reduction albicans virulence biofilm formation inhibition hyphal formation critical virulence trait synthetic version mature peptide potently blocks biofilm development solid substrates multiple media conditions disrupts preformed biofilms resistant current antifungal agents entv protective three fungal infection models nanomolar lower concentrations first nematodes treated peptide completely resistant killing albicans peptide also protects macrophages augments antifungal activity finally entv reduces epithelial invasion inflammation fungal burden murine model oropharyngeal candidiasis three models peptide greatly reduces number fungal cells present hyphal form despite profound effects entv effect albicans viability even presence significant host mimicking stresses findings demonstrate entv potential antifungal agent targets virulence rather viability
article advocates use new architectural features commonly found many cores replace machine model underlying unix like operating systems present general abstract many core machine model proof concept implementation first evaluation results context emerging many core hardware multi threaded architecture without support interrupts proposed approach makes possible reuse shelf multithreaded multiprocess software massively parallel architectures without need change code use custom programming models like cuda opencl benefits include higher hardware utilization higher performance higher energy efficiency workloads common general purpose platforms datacenters clouds benefits also include simpler software control hardware platform enabling factor evolution parallel programming languages
background high throughput sequencing technologies become fast cheap past years result large scale projects started sequence tens several thousands genomes per species producing high number sequences sampled genome highly redundant collection similar sequences called pan genome transformed set sequences colored genomes belong colored bruijn graph dbg extracts sequences colored mers strings length stores vertices results paper present alignment free reference free incremental data structure storing pan genome dbg bloom filter trie bft data structure allows store compress set colored mers also efficiently traverse graph bloom filter trie used index query different pangenome datasets compared another state art data structure bft two times faster build using amount main memory querying mers bft times faster using times less memory conclusion present novel succinct data structure called bloom filter trie indexing pan genome colored bruijn graph trie stores mers colors based new representation vertices compress index shared substrings vertices use basic data structures lightweight substrings storage well bloom filters efficient trie graph traversals experimental results prove better performance compared another state art data structure
efficiency enhancement coal fired power units becomes basis reduction consumption primary fuels result emissions steam parameters increasing effective way improve efficiency electricity generation progress materials engineering led common implementation technology power units ultra supercritical parameters next generation technology advanced ultra supercritical parameters usc opens new perspectives obtaining higher efficiency electricity generation exceeding net efficiency barrier apart increase steam parameters requires optimisation thermodynamic cycle together modernisation flow system steam condensers regenerative water heaters development advanced ultra supercritical technologies subject european japanese american chinese projects aims completion power unit live steam parameters degrees mpa net efficiency exceeding paper presents results calculations performed conceptual power unit two configurations single double steam reheat ccs directive contains clause providing new construction power installations capture ready newly built power unit gives possibility optimized integration capture installation power efficiency loss related integration capture process reduce due state knowledge capture methods ability application high power unit chemical absorption considered paper capture installation requires large amount heat solvent regeneration appropriate quantity quality cooling system discharge waste heat power drive compressor auxiliary equipment pump fans paper steam ccu extracted crossover pipe design crossover pressure significant impact power unit efficiency reduction level required ccu improve power unit efficiency however lower crossover pressure results efficiency looses part load operation therefore analysis power unit operation partial load various design crossover pressure considered slight improvement power unit efficiency gained also recovery waste heat overhead condenser compressor intercoolers feed water preheating system elsevier ltd rights reserved
prostate cancer age androgen dependent disease paradoxically systemic levels androgens decline age risk rises correlation systemic androgen levels risk systemic androgen levels reflect levels androgens prostate tissue metastatic changes androgen biosynthesis pathway hormone therapy result increased levels androgens cancer tissue contribute continued androgen receptor signaling possible similar changes occur normal prostate tissue androgen levels decline age contributes tumorigenesis present study sought determine whether rat prostate able maintain functional levels androgens despite low serum testosterone levels rats castrated implanted capsules achieve castrate normal sub physiological supra physiological levels testosterone weeks treatment used quantify levels testosterone dihydrotestosterone dht serum prostate tissue quantitative pcr used quantify expression genes involved androgen signaling axis despite significantly different levels testosterone dht present serum testosterone dht concentrations prostate tissue different testosterone treatment groups similar furthermore expression androgen regulated genes prostate similar among testosterone treatment groups demonstrating rat prostate maintain functional level androgens despite low serum testosterone levels low testosterone treatment resulted significant alterations expression androgen biosynthesis genes may related maintaining functional androgen levels
purpose study investigate logotherapeutic model described frankl explains relationships among search meaning life presence meaning life existential vacuum existential frustration noogenic neurosis power pleasure sample college students large mid atlantic university completed paper pencil instruments variables structural equation modeling used test compare four competing alternative models relationships among aforementioned constructs two models exhibited excellent fit one model good fit fourth model poor fit two best models one treated power pleasure outcomes noogenic neurosis treated causes noogenic neurosis limitations suggestions future research implications clinical practice also discussed
introduction emerging reemerging viral infections represent major concern human veterinary public health urgent need development broad spectrum antivirals areas covered recent strategy antiviral research based identification molecules targeting host functions required infection multiple viruses number fda approved drugs used treat several human diseases cationic amphiphilic drugs cads ability accumulate inside cells affecting several structures functions hijacked viruses infection review summarized cads chemical properties effects cells reported main fda approved cads identified far potential antivirals drug repurposing studies expert commentary although concerns regarding efficacy possible side effects label use cads antivirals seem represent promising starting point development broad spectrum antiviral strategies knowledge mechanism action required improve antiviral activity reduce risk side effects
objectives examine parent report flourishing children hearing impairments compared children without hearing impairments explore whether school engagement bullying related child flourishing methods participants children hearing impairments children without hearing impairments years age caregivers completed telephone interviews child functioning national survey children health results children without hearing loss higher parent reported flourishing compared children hearing loss controlling child demographics race age sex school engagement positively related flourishing children hearing loss bullying behaviors related flourishing children hearing loss conclusion improving school engagement may increase flourishing children hearing loss critical given children hearing loss experience lower flourishing children without hearing loss examining relationships among risk resilience factors flourishing children hearing loss provide information interventions enhance adaptation children elsevier ireland ltd rights reserved
propose asymmetric dependence individuals power produces asymmetric social distance high power individuals feeling distant low power individuals insight articulate predictions power affects social comparison susceptibility influence mental state inference responsiveness emotions explain high power individuals greater experienced social distance leads engage abstract mental representation mediating process construal level generates predictions power affects goal selection pursuit attention desirability feasibility concerns subjective certainty value behavior correspondence self control person perception also reassess approach inhibition theory power noting limitations predict evidence directly supporting proposed mechanisms finally discuss moderators methodological recommendations study power social distance perspective
introduction methadone common opioid use opioid substitution therapy relation methadone electrocardiographic findings nearly well known relationship electrocardiographic indexes hormonal changes well recognized objective evaluate hormonal changes patients taking methadone maintenance treatment mmt effects electrocardiographic indexes comparison healthy control groups patients methods patients receiving mmt therapy least last six months healthy subjects enrolled study serum estradiol testosterone luteinizing hormone follicle stimulating hormone thyroid function tests measured mean interval interval pri qrs duration also documented maximum results significant differences hormonal parameters mmt control groups significant relation found hormonal parameters dose duration methadone usage patients group qtc significantly higher methadone users control groups qtc significant negative correlation testosterone level males significant difference found pri patients control groups conclusion electrocardiographic changes important complication methadone seems related low testosterone level men
race gender categories although long presumed perceived independently inextricably tethered social perception due part natural confounding phenotypic cues predicted target gender would affect race categorizations consistent hypothesis feminine faces compelled white categorizations masculine faces compelled asian black categorizations racially ambiguous targets study monoracial targets study real facial photographs study efficiency judgments varied concomitantly white categorizations rendered rapidly feminine relative masculine faces opposite true asian black categorizations studies moreover effect gender categorization efficiency compelled racial phenotypicality black targets study finally targets race prototypicality held constant gender still influenced race categorizations study findings indicate race categorizations biased presumably unrelated gender cues
autoimmune diseases characterized aberrant immune responses healthy cells tissues however exact mechanisms underlying development conditions remain unknown regulatory cells tregs subset mature cells important role maintaining immune homeostasis preventing autoimmune diseases forkhead box foxp member fork head transcription factor family recognized marker tregs decreased number function tregs peripheral blood related tissues demonstrated systemic lupus erythematosus systemic sclerosis autoimmune diseases least partially regulated epigenetic mechanisms epigenetics refers study potentially heritable alterations gene expression without underlying changes nucleotide sequence mainly including dna methylation histone modification micrornas mirnas example dna methylation status cpg islands foxp gene may affected normal aging regulated environmental factors plays important role modulating homeostasis foxp expression tregs foxp gene tregs also shows distinct acetylation trimethylation levels histone compared effector cells leading open chromatin structure micrornas mir mir mir also exert important influence differentiation development immunological functions tregs aberrant epigenetic modifications affecting foxp key genes tregs contribute disease activity tissue inflammation autoimmune diseases holds great potential providing novel targets epigenetic therapies advances research epigenetic regulation tregs may also lead identification new epigenetic biomarkers diagnosis prognosis
optimal cooling rate critical factor affecting survival biological cells cryopreservation paper system board cooling rate controlled cryopreservation low temperature degrees environments developed disposable biocompatible polydimethylsiloxane pdms storage chambers top localized heaters printed circuit boards assembly allows storage chambers removed temperature controlled board transferred degrees freezer liquid nitrogen tank long term cryopreservation use pdms enables insertion syringe needle loading samples freezing seeding extracellular ice formation pdms storage chambers fabricated using polymethyl methacrylate mold made using laser cutting machine device copper thin film deposited fiberglass epoxy substrate using electroless plating patterned using photolithography techniques micro serpentine shape copper film functioned simultaneously resistive heating element temperature sensor proportional integral derivative feedback control program embedded microcontroller semi actively control transient temperature profiles freezing process multiple samples different cooling rate requirements results show proposed devices able maintain stable cooling rate degrees min covers optimal range mammalian cell types low cell membrane permeability low cooling rates required heat transfer simulation established model transient spatial temperature profiles device freezing preliminary biological tests yeast cells survival rates board cryopreservation suggest prototype device low cost reliable convenient tool laboratory use cryopreservation
recently biomaterial scientists married materials engineering immunobiology conceptualize new immunomodulatory materials special class biomaterials modulate harness innate properties immune functionality enhanced therapeutic efficacy generally two fundamental strategies followed design immunomodulatory biomaterials immuno evasive immuno mimetic immuno suppressing immuno inert biomaterials immuno activating immuno enhancing biomaterials article highlights development application number immunomodulatory materials categorized two general approaches
compare adoption healthy lifestyle behaviors including spiritual growth nutrition physical activity interpersonal relations health responsibility stress management healthcare workers workers professions cross sectional observational study among convenience sample healthcare workers professions health promoting lifestyle profile hplp item measure regarding six components healthy lifestyle demographic characteristics education income work duration self rated health also collected multivariable linear models specified components healthy lifestyle groups comparable age family status income self rated health results multivariable linear models revealed healthcare workers adopt better nutrition beta physical activity beta greater health responsibility beta compared professions differences found regard spiritual growth beta interpersonal relations beta stress management beta healthcare workers adopt better healthy lifestyle components may perceived direct influence health outcomes namely nutrition physical activity health responsibility research explore reasons observed differences may enable designing health improving interventions
purpose laparoscopic cholecystectomy usually performed general anesthesia aim study investigate availability safety side effects combined spinal epidural anesthesia csea comparison methods forty nine patients plan included study patients randomly divided csea groups intraoperative postoperative adverse events postoperative pain levels compared groups results anesthesia procedures surgeries patients successfully completed organization pneumoperitoneum csea group patients suffered shoulder pain patients suffered abdominal discomfort complaints recovered fentanyl administration patient developed hypotension recovered fluid replacement need use vasopressor treatment postoperative shoulder pain significantly less observed csea group incidence postoperative nausea vomiting ponv less observed csea group statistically significant group csea patients suffered urinary retention patients suffered spinal headache postoperative pain parameters except hour less observed csea group less vas scores less need analgesic treatment csea group comparing group conclusion csea used safely laparoscopic cholecystectomies less postoperative surgical field pain shoulder pain ponv advantages csea compared
journalists perceive influence different types media perception affects journalists attitude toward supporting censorship explored conducting survey among german journalists predicted stronger journalists perceive political influence media public approve example demands restricting influence time behavioral intentions regarding censorship depend less perception media influences directly attitude toward restrictions
rapid development broadband wireless access technology mobile terminal mobile internet developed quickly recent years however malicious applications become one key factors threatening development mobile internet order protect vital interest mobile terminal users mobile malicious applications effectively prevented controlled paper analyzes existence limitation current mobile application detection technology uses symbolic execution base stream tracing malicious code writers usually hide malicious code execution path special circumstances trigger malicious behaviors constraint solve execution routes sensitive calls ultimately solve specific backstage behaviors trigger conditions experiments evaluate performance proposed method experimental results show method work well
stunting measure overall nutritional status major public health concern association child mortality morbidity later adult performance study examined effects pregnancy events birth characteristics infant risk exposure stunting age years study established soweto urban south african township included mother infant pairs enroled birth twenty plus longitudinal birth cohort study total children stunted age years males greater risk females odds ratio confidence interval unadjusted analysis male sex household socio economic status ses overcrowding maternal age maternal education single motherhood ethnicity birth weight gestational age duration infant breastfeeding significantly associated stunting multivariable analysis higher birth weight protective stunting sexes higher maternal education protective females adjusted odds ratio aor whereas wealthier household ses protected males aor richest ses group similar settings current stunting prevention efforts focussing primarily providing targeted proximal interventions food supplements risk undermining critical importance addressing key distal determinants stunting ses maternal education
purpose printer used realise compartmental dosage forms containing multiple active pharmaceutical ingredient api formulations work demonstrates microstructural characterisation printed solid dosage forms using ray computed microtomography terahertz pulsed imaging tpi methods printing performed either polyvinyl alcohol pva polylactic acid pla structures examined tpi liquid self nanoemulsifying drug delivery system snedds formulations containing saquinavir halofantrine incorporated printed compartmentalised structures vitro drug release determined results clear difference terms pore structure pva pla prints observed extracting porosity pva pla prints pore length pore volume data print resolution accuracy characterised tpi basis computer aided design cad models dosage form compartmentalised pva structures larger designed conclusions printer reproduce specific structures accurately whereas prints deviate designed model microstructural information extracted tpi assist gain better understanding performance printed dosage forms
analytic design guide design three stage cascade cmos operational amplifier compensated boosting frequency compensation acbc method presented paper procedure allows electrical parameters gain bandwidth gbw product phase margin related value circuit elements aspect ratio biasing currents transistors presented design guide suited pencil paper design yields accurate performance without unnecessary circuit constraint introduction simulation results using tsmc cmos process verifies accuracy robustness proposed procedure various load capacitors circuit conditions simulated based obtained results presented design guide comprehensive efficient since leads frequency response parameters aspect ratio mosfets
context awareness activity recognition becoming hot research topic ambient intelligence ami ubiquitous robotics due latest advances wireless sensor network research provides richer set context data allows wide coverage ami environments however using raw sensor data activity recognition subject different constraints makes activity recognition inaccurate uncertain dempster shafer evidence theory known belief functions gives convenient mathematical framework handle uncertainty issues sensor information fusion facilitates decision making activity recognition process dempster shafer theory applied represent manipulate contextual information uncertainty wide range activity aware systems however using theory needs solve mapping issue sensor data high level activity knowledge present paper contributes new ways apply dempster shafer theory using binary discrete sensor information activity recognition uncertainty propose efficient mapping technique allows converting aggregating raw data captured using wireless senor network high level activity knowledge addition propose conflict resolution technique optimize decision making presence conflicting activities validation approach used real dataset captured using sensors deployed smart home results demonstrate improvement activity recognition provided approaches results demonstrate also accuracy activity recognition using dempster shafer theory proposed mappings outperforms bayes classifier decision tree
objective single institution case control study conducted test hypothesis history smoking associated higher risk developing mpns compared cll methods cases mpn patients diagnosed year period controls patients cll diagnosed period odds ratios confidence intervals calculated adjusted gender age logistic regression results significant association personal history smoking risk mpns compared cll observed mpns classified mpns conclusions larger case control study described positive association risk mpn history smoking general mpn population association might explained chronic inflammatory state oxidative stress response smoking eliciting genomic instability stem cell compartment ultimately clonal evolution resulting mpns
preceding work brasiello developed mathematical model eggplant dehydration taking account shrinkage effects although model provided good results predicting total water weight loss slices time information given capability predicting water content profiles inside material important issue order catch fundamental aspects dehydration shrinkage paper analyze evolution water content profiles inside cylindrical samples eggplant dehydration using mathematical model takes account shrinkage effects particular show good agreement numerical derived spatial profiles magnetic resonance imaging mri data available literature model parameters calculated suitable simplified procedure uses experimental data samples different shape numerical results compared derived procedure applied fick diffusion equation elsevier ltd rights reserved
solar energy promising energy source covering great variety applications low high temperature levels study mature concentrating technology commercial parabolic trough collector eurotrough investigated energetically exergetically great temperature range pressurized water therminol nitrate molten salt sodium liquid air carbon dioxide helium examined working fluids one studied proper temperature range first part study optimum mass flow rate determined every working fluid separately point exergetic energetic performance collector operating working fluids examined final results prove liquid sodium leads global exergetic maximum efficiency inlet temperature equal maximum exergetic performance helium carbon dioxide air respectively moreover pressurized water best working medium temperature levels carbon dioxide helium solutions temperatures greater thermal analysis performed ees tool elsevier ltd rights reserved
difficulties figurative language comprehension documented adult dyslexia dys present research investigated comprehension generation metaphors children adolescents adults without dys also tested contribution executive function metaphor processing multiple choice questionnaire conventional novel metaphors used assess comprehension concept explanation task used test conventional novel metaphor generation verbal creativity findings indicated differences dyslexic children control group conventional metaphor comprehension however groups performed similarly novel metaphor comprehension test furthermore although children adolescents dys showed similar performance metaphor generation typically developing peers adults dys generated metaphors controls scores tests verbal knowledge mental flexibility contributed prediction conventional metaphor comprehension scores non verbal tests mental flexibility contributed prediction novel metaphor generation findings suggest individuals dys impaired novel metaphor comprehension metaphor generation metaphor comprehension generation utilize different cognitive resources copyright john wiley sons ltd
telecare medicine information systems tmis provide flexible convenient health care however medical records transmitted tmis exposed unsecured public networks tmis vulnerable various types security threats attacks provide privacy protection tmis secure efficient authenticated key agreement scheme urgently needed protect sensitive medical data recently mishra proposed biometrics based authenticated key agreement scheme tmis using hash function nonce claimed scheme could eliminate security weaknesses yan scheme provide dynamic identity protection user anonymity paper however demonstrate mishra scheme suffers replay attacks man middle attacks fails provide perfect forward secrecy overcome weaknesses mishra scheme propose three factor authenticated key agreement scheme enable patient enjoy remote healthcare services via tmis privacy protection chaotic map based cryptography employed proposed scheme achieve delicate balance security performance security analysis demonstrates proposed scheme resists various attacks provides several attractive security properties performance evaluation shows proposed scheme increases efficiency comparison related schemes
early life stress long lasting effects stress response emotions behavior throughout individual life clinical reports demonstrated child abuse victims exhibit impairments reward associated behavior yet mechanism effect remains unclear maternal separation coupled social isolation widely used model early life stress rodent studies employed mice subjected clarify long term effect early life stress reward seeking involving palatable foods conditioned place preference cpp paradigm prior experience decreased exploration time chocolate paired compartment adult female mice male mice focused mesolimbic dopamine pathway associated reward seeking behavior measured mrna protein levels tyrosine hydroxylase ventral tegmental area vta dopamine receptors nucleus accumbens nac female mice significantly lower receptor mrna protein levels controls whereas expression receptor similar groups mrna protein levels unchanged male mice attempting elucidate mechanism underlying downregulation receptor nac females found hypermethylation drda promoter region results suggest early life stress affects reward seeking behavior female mice may associated downregulation receptor nac via epigenetic modification promoter region elsevier rights reserved
smart mobility day day becoming one crucial issues address order reduce environmental impacts global warming acidification photochemical smog among others growing concerns urban air quality driving force cleaner efficient transport systems several new transport technologies developed particular concerning electric vehicles considered suitable solution urban air pollution problems however vehicles require electric electronic devices might give rise new set environmental problems production operation disposal phases electric vehicles really cleaner solution paper aims answering question comparing two kinds vehicle lithium battery powered electric bike hydrogen fuel cell operated one using internal combustion engine vehicles benchmark fuel cell bike uses proton exchange membrane fuel cell pemfc convert hydrogen electricity study life cycle assessment applied evaluate environmental burdens production two vehicles compare environmental performances per travelled study includes vehicle road operation also embraces production distribution bikes electric battery pemfc energy carriers electricity hydrogen vehicle entire lifetime lca evaluation vehicle production phases shows construction bike results impacting bike considered categories due presence complex components technology instead boundary shifted operational phases vehicles including energy carriers production situation reversed environmental performance bike results better one bike hydrogen energy publications llc published elsevier ltd rights reserved
laboratory tests conducted track materials evaluate constitutive parameters three different sets constitutive relationships namely non linear analysis straight analysis coupled analysis model test results finite element analyses using various constitutive relationships compared coupled analysis provided better prediction measured results compared non linear straight analyses detailed parametric study prototype track performed using coupled analysis evaluate effects geosynthetics track reinforcement mud pumping reduction geogrid reinforcement found significantly reduce tie displacement low subgrade modulus values effective subgrade shear strength parameters geogrid reinforcement equally effective reducing tie displacement within subballast thickness range high excess pore water pressure coupled low effective cohesion gives rise mud pumping problems silty soil subgrades provision geotextiles subgrade surface facilitates quick plane drainage dissipation pore water pressure thus excess pore water pressure observed lower geotextile stabilized track compared unreinforced track indicating reduction mud pumping potential former elsevier ltd rights reserved
background activation plasma enzyme systems contributes hereditary angioedema attacks aimed study activation markers fibrinolytic coagulation contact systems larger number paired samples obtained inh hae patients symptom free periods attacks methods eleven parameters factors xii inhibitor activity concentrations dimer prothrombin fragments plasminogen plasminogen activator inhibitor pai thrombin anti thrombin iii tat complex fibrinogen measured along prothrombin time activated partial thromboplastin time aptt using commercial kits compared markers samples obtained patients attack free periods edematous episodes forty healthy subjects matching sex age served controls results compared healthy controls significantly higher fxi fxii activity well dimer prothrombin fragments tat levels ascertained patients symptom free periods evaluation samples symptom free periods obtained attacks revealed increase fxii activity well concentration dimer prothrombin fragments tat edematous episodes pai level prothrombin time aptt decreased significantly attacks compared symptom free periods dimer level significantly higher multiple single site attacks conclusions comparing large number paired samples symptom free periods edematous episodes allowed accurate appraisal changes occurring attacks moreover study pointed individual episodes may characterized different marker patterns
two part paper topological analysis powertrains refuse collecting vehicles rcvs based simulation different architectures internal combustion engine hybrid electric hybrid hydraulic real routes proposed first part characterization standard route performed analyzing average power consumption frequent working points internal combustion engine ice real routes information used define alternative powertrain architectures hybrid hydraulic powertrain architecture proposed modelled proposed powertrain model executed using two different control algorithms without predictive strategies data obtained real routes calculation engine algorithm runs vehicle models real routes presented used simulations calculation engine specifically designed analyze different alternative powertrain delivers performance original ice finally overall performance different architectures control strategies summarized fuel energy consumption table used second part paper compare different architectures based hybrid electric powertrain overall performance different architectures indicates use hybrid hydraulic powertrain simple control laws reduce fuel consumption
paper focus enhancing security network layer already developed two algorithms pathfinder secure load sharing sls algorithm main purpose find possible paths different intermediate nodes allow restraining attacks based sniffing initially limitation nodes pathfinder handle paper propose new version algorithms allow managing networks hundreds nodes validate proposal implementation new algorithms made simulation prove addition efficiency handle great number nodes new way processing major impact router performances calculating routes dispatching messages
article explores psycho social space autobiographical collective memory concerning massive social traumas conceptualized third type memory image termed individuals appear remember autobiographical memories elder family members even though could either born trauma happened autobiographers extremely young time experience emotional memories furthermore connect collective memories social traumas ethnic national groups examples memories holocaust naqba examined furthermore roles memory images play peace building reconciliation discussed
elliptic curve cryptography ecc one popular public key cryptosystems recent years due higher security strength lower resource consumption however noninvasive side channel attacks scas proved big threat ecc systems many previous researches paper propose low area time product ecc coprocessor ability resist existing noninvasive scas basic countermeasures relied underlying finite field arithmetics randomized montgomery domain blind intermediate value iterations scalar multiplication prevent adversaries cracking private key statistical methods meanwhile optimize modular division modular multiplication algorithms fix operating time resist certain timing attacks montgomery ladder algorithm makes coprocessor immune simple scas efficiently implement coprocessor present hybrid operation sequence merely needs one multiplication module one division module complete entire operations synthesis results indicate design superior related works area time product atp extra overhead paid countermeasures less
piezoelectric based hydraulic actuator type piston cylinder device operated internal flow energy recently artificial muscle micro actuator developed using new smart material internal flow control thus actuating velocity fabricated integrated hybrid system investigated using pumping frequency load weight actuating velocity calculated using developed program numerical result compared experimental result validate numerical program also internal flow rate measured analyze pump efficiency experimentally flow rate inside integrated hybrid actuator calculated using cfd program various pumping frequencies compared experimental results maximum outlet velocity obtained pumping frequency velocity decreased point due flow loss
almost every child kurdistan iraq currently growing son daughter survivors collective persecution genocidal activity carried saddam hussein regime aim study communicate first impressions second generation situation examine possible effects transgenerational transmission unprocessed trauma based fieldwork interviews parents experienced torture chemical attacks adolescent children strong indications unprocessed traumatizations found parents side irritable show dysfunctional parenting behavior form physical abuse indications boundary blurring parentification well psychological burden including problems studying dysphoric mood found among children politicians professionals kurdistan iraq need aware possible transmission parents traumatic experiences children provide adequate services
sensitization phase allergic contact dermatitis proinflammatory cytokine tumour necrosis factor tnf plays important role promoting epidermal langerhans cell migration draining lymph nodes also plays role elicitation phase tnf gene tnf located within themajor histocompatibility complex region many single nucleotide variants exist promoter region tnf may either increase decreasemrnatranscription therefore lead higher lower levels tnf extensively studied single nucleotide variant tnf base pair substitution promoter region location relative transcription start site tnf believed increase transcription lead higher tnf levels role tnf allergic contact dermatitis functionality tnf reviewed article association genetic variants disease studied case control design case control studies investigating association tnf allergic contact dermatitis published contradictory results reviewed critically suggestions future case control studies topic made
initial stage learning programming process arduous task novice students simultaneously learn syntax programming language understand algorithmic logic program based well comprehend basic concepts programming principles problems students faced become even greater teachers employ complex environments minimum graphical facilities instead user friendly educational programming environments time constant technological developments indicate global market continue require highly skilled computer programmers thus usage advanced educational environments properly train future professionals essential one reasons new type technology called serious games started raising great interest educational settings using serious games education combines increased motivation students incorporation course materials within games tasks aim paper apply educational massive multiplayer online role playing game mmorpg named cmx university settings evaluate efficiency successfully teaching programming elements entertaining engaging students interesting environment game applied two groups students already familiar basic computer programming concepts populated units learning regarding arrays programming language groups engage interact game environment senseis tasks players record behaviours activities additionally monitor ways game facilitated students comprehension difficult concepts enhanced ability program code using programming language paper presents implementation elaborates game evaluation based specific axes players performance game difficulty game entertaining elements players knowledge skills game performance cmx educational game case study evaluated following methodologies used related works results indicated majority students positively inclined using cmx learning additional computer programming elements satisfied game scenario variety activities encountered finally paper presents future work aims enhance expand game features order increase students performances
polymyalgia rheumatica pmr almost exclusive disease adults age cases reported two year old females visited locomotor pain clinic multiple joint pain increased acute phase reactants rheumatologic markers hla checked serum protein electrophoresis serum immunofixation electrophoresis imaging studies including plane image sonography magnetic resonance image done fludeoxyglucose positron emission tomography computed tomography fdg pet showed characteristic findings pmr without evidences sacroiliitis since pmr develop mid high index suspicion necessary younger patients presenting bilateral pain shoulders hips back elevated acute phase reactants furthermore addition previous case reports fdg pet helpful making early differential diagnosis pmr patients age present two cases pmr onset mid emphasizing importance diagnostic imaging early differential diagnosis pmr
one essential engineering problem developing industrial enzymatic process concerns choice reactor operating alternative based priori knowledge process kinetics enzyme inactivation characteristics multi enzymatic system involving complex interactions among enzymes exhibit optimal activity different parametric domains high order deactivation problem requires extended analysis optimization control engineering problems become challenging due process high nonlinearity presence large number complex constraints translate multi objective optimization problem solved case elegant option developed paper obtain sets pareto optimal solutions also called pareto optimal fronts successively generated pairs adverse objectives final choice enzymatic reactor operating policy results comparative analysis pareto fronts exemplification made complex case oxidation glucose keto glucose kdg presence pox pyranose oxidase catalase continuously operated three phase mechanically agitated semibatch reactor mascr immobilized enzymes alginate beads optimal operating policy choice based minimum amount required pox ensures imposed reaction conversion maximum reactor productivity various technological constraints catalase ratios elsevier ltd rights reserved
objective investigate influence vestibular function dynamic postural stability assessed functional reach test frt timed test tug study design retrospective study setting tertiary referral center subjects methods frt tug performed patients dizziness effects peripheral vestibular dysfunction assessed caloric test cervical vestibular evoked myogenic potentials cvemps airconducted sound tone burst results frt tug analyzed results neither frt tug scores showed significant differences relation results caloric test frt scores patients showed abnormal cvemp responses sides significantly smaller patients showed normal cvemp responses tug scores patients showed abnormal cvemp responses sides significantly greater patients showed normal cvemp responses conclusion vestibulo spinal reflex mediated saccule afferents one factors influence maintenance dynamic postural stability measured frt tug
context objective relationship sex hormones asthma evaluated several studies aim review article investigate association asthma female sex hormones different conditions premenstrual asthma use oral contraceptives menopause hormone replacement therapy pregnancy design setting narrative review medical literature universidade federal tocantins uft universidade federal sao paulo unifesp methods searched capes journal portal brazilian platform provides access articles medline pubmed scielo lilacs databases following keywords used based medical subject headings asthma sex hormones women use oral contraceptives results associations sex hormones asthma remain obscure adults asthma common women men addition mortality due asthma significantly higher among females immune system influenced sex hormones either progesterone stimulates progesterone induced blocking factor cytokines contraceptives derived progesterone estrogen stimulate transcription factor gata conclusions associations asthma female sex hormones remain obscure speculate estrogen fluctuations responsible asthma exacerbations occur women anti inflammatory action estrogen decreases tnf alpha production interferon gamma expression cell activity suggest studies highlight underlying physiopathological mechanisms contributing towards interactions conducted
background objective manual transformation dna fingerprints dominant markers input tools population genetics analysis time consuming error prone task especially researcher deals large number samples addition researcher needs use several tools population genetics analysis situation worsens due incompatibility data formats across tools goal work consists automating banding patterns gel images input generation great diversity tools devoted population genetics analysis methods thorough analysis tools population genetics analysis dominant markers tools working phylogenetic trees detected input requirements systems case programs devoted phylogenetic trees newick nexus formats widely employed whereas population genetics analysis tool uses specific format order handle diversity formats latter case developed new xml format called popxml takes account variety information required population genetics analysis tool moreover acquired knowledge incorporated pipeline ceti system tool analysing dna fingerprint gel images reach automatisation goal results implemented gel system pipeline automatically generates gel banding patterns input tools population genetics analysis phylogenetic trees pipeline employed successfully generate thousands banding patterns input population genetics analysis tools tools managing phylogenetic trees conclusions gelj become first tool fills gap gel image processing software population genetics analysis dominant markers phylogenetic reconstruction tree editing software achieved automating process generating input latter software gel banding patterns processed gelj elsevier ireland ltd rights reserved
cell cell cell matrix communications play important roles cell proliferation differentiation gap junction proteins mediate signaling communication exchanging small molecules dramatically stimulating intracellular signaling pathways determine cell fate vertebrates gap junction families pannexins panxs connexins cxs unlike cxs functions panxs fully understood skeletal formation panx abundantly expressed gap junction proteins family panx induced transient stage proliferation differentiation chondrocytes osteoprogenitor cells panx regulates chondrocyte osteoblast differentiation via activation intracellular signaling pathways multiple channel activities hemichannels endoplasmic reticulum channels gap junctions moreover panx also inhibits osteoprogenitor cell proliferation promotes cell cycle exit inactivation wnt catenin signaling activation panx knockout mice severe skeletal abnormalities mice phenotypic analysis panx mice indicates panx regulates terminal differentiation chondrocytes promoting vascular endothelial growth factor vegf matrix metalloproteinase mmp based generation panx mice panx upstream osteogenesis panx promotes expression regulating wnt catenin signaling osterix expression although panx function ways function channel via hemichannels gap junction routes review discuss current knowledge regarding roles panx skeletal formation address potential new therapies treatment diseases pathologies associated panx osteoarthritis
paper deals novel type hybrid motion system construction machines based common pressure rail shared hydromechanical power split transmission secondary controlled work hydraulics construction machine driveline work functions complex coupled motion system design effective hybrid system needs take subsystems account studies energy efficient hybrid systems construction machines hitherto principally focused one subsystem time work hydraulics driveline paper demonstrates use case specific transmission concept proposal medium sized wheel loader system modelled simulated using optimal energy management strategy based dynamic programming results show benefits throttle free bidirectional link machine subsystems energy storage taking advantage complex power flows power split transmission
sintered magnets exposed magnetic fields many applications permanent magnet electric motors measured losses sintered magnets closed circuit arrangement using fields root mean square values peak amplitude frequency range two magnet grades different dysprosium content investigated around remanence point low grade material showed significant hysteresis losses whereas losses high grade material dominated classical eddy currents kerr microscopy images revealed hysteresis losses measured low grade magnet mainly ascribed grains sample surface multiple domains confirmed high grade material subsequently exposed magnetic fields larger number surface grains multiple domains also present step demagnetization curve attributed surface grain reversal reached rise measured hysteresis losses evident low grade material operating point slightly offset remanence point zero field bypassed losses also fairly well described classical eddy current theory elsevier rights reserved
vernier operation signal flow graph sfg graphical approach analyzing intricate photonic circuits mathematically quick calculation optical transfer function analysis cascaded microring resonators cmrr made ingaasp inp semiconductor presented using signal flow graph sfg method enables modelling transfer function passive cmrr passive filters mostly characterized frequency response theoretical calculations system performed vernier effects analysis two mrrs radius vertically coupled together used generate resonant peaks phase dispersion group delay generated signals analyzed
charge recombination dark current two main negative processes dye sensitized solar cells dsscs herein new triphenylamine electron donor group developed resist charge recombination dark current triphenylamine sensitized solar cells new donor group coplanar triphenylamine moiety therefore outperforms conventional triphenylamine moiety higher electron donor ability evidenced vis spectroscopic analysis furthermore structure help resist dark current restrain charge recombination demonstrated dark current electrochemical impedance spectroscopic eis studies sensitizer nuisti including novel donor group achieves higher energy conversion efficiency conventional triphenylamine elsevier ltd rights reserved
severe global climate changes result consecutive torrential rains rainy season causes water loss soil erosion effective water soil conservation geotextiles commonly used geotechnical engineering geotextiles able isolate soil filter water reinforce soil therefore material geotextiles acid resistant alkali resistant polypropylene polyester pet study uses fibers skin pet plied yarns core form pet composite tubular knits cord knitting machine pet plied yarn fed specified tensile strength tooth number drive gear varies mechanical property test results show drive gear teeth increases tensile strength resulting tubular knits however drive gear teeth tensile strength decreases optimal core coverage occurs drive gear teeth
classical benzodiazepines widely used sedatives anxiolytics anticonvulsants exert therapeutic effects interactions heteropentameric gaba receptors composed two alpha two beta one gamma subunit high affinity binding site located interface gamma adjacent alpha subunit alpha subunit gene family consists six members receptors homomeric mixed respect alpha subunits previous work suggested benzodiazepine binding site ligands selectivity individual gaba receptor subtypes defined benzodiazepine binding alpha subunit may fewer side effects may even effective diseases schizophrenia autism chronic pain respond well classical benzodiazepines distributions individual alpha subunits across cns extensively characterized however gaba receptors may contain two different alpha subunits distribution subunits necessarily reflect distribution receptor subtypes respect benzodiazepine pharmacology present study used vivo flumazenil pet vitro flumazenil autoradiography combination gaba receptor point mutated mice characterize distribution two prevalent gaba receptor subtypes alpha alpha throughout mouse brain results agreement published vitro data high levels alpha containing receptors found brain regions neuronal network anxiety alpha alpha subunit combinations predictable individual subunit levels additional experiments explored vivo flumazenil pet determine degree receptor occupancy gaba receptor subtypes following oral administration diazepam dose occupy sensitive receptors independent receptor subtype agreement published data vivo studies wild type mice conclusion resolved quantitative distribution alpha alpha containing homomeric mixed gaba receptors vivo millimeter scale demonstrate regional drug receptor occupancy vivo gaba receptor subtypes determined flumazenil pet information valuable drug development programs aiming subtype selective benzodiazepine site ligands new therapeutic indications
anti fat bias healthcare providers medical students serious implications quality care higher weight patients studies interventions aimed reducing anti fat attitudes medical students generally disappointing little enduring effect possible students may receptive prejudice reducing influences others due underlying differences personal characteristics also possible attitudes toward patients specifically may differ anti fat attitudes general prejudice reduction effectiveness patient specific attitudes yet evaluated present study explored effect general patient specific anti fat attitudes contact higher weight individuals prior medical school training designed increase medical students empathy toward patients encouraging take patient perspective clinical encounters moderating role individual difference factors effectiveness contact student reported hours empathy training patient specific attitudes assessed total students enrolled across medical schools completed online survey start first year medical school end fourth year favorable contact experience higher weight patients predicted improved attitudes toward heavier patients years medical school appeared sufficient partially offset effects dislike higher weight individuals baseline impact favorable contact general anti fat attitudes less strong highlighting importance using target specific outcome measures positive effects favorable contact attitudes toward higher weight patients differ based students baseline levels social dominance orientation dispositional empathy need cognitive closure contrast effectiveness training vary student characteristics generally effective students egalitarian empathic baseline little effect even adverse effects students low traits overall however perspective taking training produced small improvements attitudes toward higher weight patients
one key issues control design active magnetic bearing amb systems tradeoff simplicity controller structure performance closed loop system achieve tradeoff paper proposes design fractional order proportional integral derivative fopid controller fopid controller consists two additional parameters comparison conventional pid controller feasibility fopid amb systems investigated rotor suspension radial axial directions tuning methods developed based evolutionary algorithms searching optimal values controller parameters resulting fopid controllers tested compared conventional pid controller well advanced controllers linear quadratic gausian lqg controllers comparison made terms various stability robustness specifications well dimensions controllers implemented lastly validate proposed method experimental testing carried single stage centrifugal compressor test rig equipped magnetic bearings results show proper selection gains fractional orders performance resulting fopid similar advanced controllers
polymer materials flammability represents major limitation use hence development polymer based advanced technologies environmental safety concerns leading progressive phasing versatile effective halogen based fire retardants far ensured satisfactory polymer fire hazard control among intensive efforts made develop new environmentally safe polymer fire protection approaches recognition paramount role played polymer surface combustion exploitation new nanotechnologies developed polymer surface engineering offer promising perspective polymer fire retardance indeed heat transfer polymer diffusion gas phase polymer degradation combustible volatiles fuel combustion occur across polymer surface characteristics regulate polymer combustion process shown engineering polymer material surface intumescent coatings layer layer nano deposition oxidic nanostructures sol gel synthesis polymer combustion conveniently slowed extinguishment complying fire safety rules specific applications creation surface barrier heat mass transfer across polymer surface elsevier rights reserved
lighting building natural lighting best key sustainable building designs daylight factor reading building exceeds recommendedpercents resulting glare causes negative effects health occupants user satisfaction space results lack output efficiency user hotel penaga adaptive reuse hotel georgetown penang malaysia awarded gold rating malaysia green rating tool green building index software used obtain data daylight factor penaga hotel penang using autodesk ecotect analysis gain simulation daylight factor
backgroundwe aimed investigate relationship hippocampal shape deformations serum cortisol levels first episode drug naive major depression disorder mdd patients methodsthirty first episode drug naive mdd patients healthy subjects recruited high resolution weighted imaging morning blood samples cortisol measurement obtained mdd patients healthy subjects hippocampal shape analysis compared hippocampal shape mdd patients healthy subjects evaluated linear correlation hippocampal shape deformations serum cortisol levels mdd patients healthy subjects resultsmdd patients showed significant inward deformations predominantly cornu ammonis subiculum bilateral hippocampi compared healthy subjects false discovery rate fdr corrected furthermore mdd patients significant linear correlation inward deformations high cortisol levels found predominantly subiculum extending fdr corrected whereas significant linear correlation observed healthy subjects conclusionsthe serum cortisol levels therefore considered associated hippocampal shape abnormalities mdd
background aim study investigate reliability automated oscillometric blood pressure monitoring presence absence atrial fibrillation hypertensive patients methods measured compared randomly selected patients arterial hypertension diagnosis times auscultatory oscillometric microlife detection system methods results study included patients males mean age years females years time measuring procedure patients sinus rhythm patients mean systolic blood pressure sbp mmhg auscultatory method mmhg oscillometric method mean diastolic mmhg mmhg patients mean sbp mmhg mmhg mean diastolic mmhg mmhg averages differences sbp dbp sinus rhythm group mmhg limits agreement mmhg limits agreement respectively patients averages differences sbp dbp mmhg limits agreement mmhg limits agreement respectively conclusions oscillometric device validated patients average gives mmhg higher systolic values patients mmhg higher values patients however limits agreement two methods reveal wide range random error rates questionable topic clinical practice could possibly affect treatment arterial hypertension patients
although missing data methods advanced recent years methodologists devoted less attention multilevel data structures observations level nested within higher order organizational units level individuals within neighborhoods repeated measures nested within individuals students nested within classrooms joint modeling chained equations imputation principal imputation frameworks single level data multilevel counterparts approaches differ algorithmically functionality appropriate simple random intercept analyses normally distributed data differ beyond purpose paper describe multilevel imputation strategies evaluate performance variety common analysis models using multiple imputation theory computer simulations derive major conclusions joint modeling chained equations imputation appropriate random intercept analyses joint model superior analyses posit different within cluster associations multilevel regression model includes level predictor cluster means multilevel structural equation model different path values level level chained equations imputation provides dramatic improvement joint modeling random slope analyses latent variable formulation categorical variables quite effective use real data analysis demonstrate multilevel imputation suggest number avenues future research
train operation adjustment kind real time multi objective large scale combination optimization problem multi restriction novel immune genetic algorithm based artificial immune algorithm genetic algorithm put forward scheduling optimization model two way marshalling train proposed solved proposed immune genetic algorithm finally instance based two way marshalling train constructed simulation results show feasibility model algorithm
consider nonlinear klein gordon maxwell system derived lagrangian integral phi four dimensional minkowski space time phi complex scalar field partial derivative partial derivative electromagnetic field appropriate nonlinear potentials system admits soliton solutions gauge invariant generalizations non topological solitons introduced studied lee collaborators pure complex scalar fields article develop rigorous dynamical perturbation theory solitons small limit electromagnetic coupling constant main theorems assert long time stability solitons respect perturbation external electromagnetic field produced background current compute effective dynamics effective dynamical equation equation motion relativistic particle acted lorentz force law familiar classical electrodynamics theorems valid scaling regime external electromagnetic fields vary slowly space time scales delta delta element work entirely energy norm approximation controlled norm times
millions people consume betel nut increased capacity work contains arecoline highly toxic several untoward side effects endocrine functions article role arecoline thyroid function metabolic stress investigated mice water food deprivation days caused ultrastructural degeneration thyro follicular cells evident pycnotic nuclei scanty rough endoplasmic reticulum mitochondria followed depletion blood serum levels alteration tsh level compared control thyroid activity also suppressed ultrastructurally well hormonal level arecoline administration arecoline treatment water deprivation food deprivation stress also caused thyroid dysfunction beyond metabolic stress evident ultrastructural degeneration thyrocytes depletion thyroid hormones mice findings suggest arecoline aggravates hypothyroid condition metabolic stress mice
development agriculture industry urbanization land use land cover lulc change resulted significant deterioration water quality severe eutrophication lakes china plateau lake ecosystem china vulnerable especially sensitive environmental change human disturbance due strong closeness species simplification oligotrophy simple food chain research focuses evaluating quantitative spatial relationships land use pattern water quality rivers inflowing fuxian lake chinas largest deep freshwater lake plateau investigate influence spatial variation land use structures topography rivers water quality distributions land use types lakes drainage basin obtained satellite images correlations land use types inflow water quality indicators examined applying statistical analysis spatial analytical function geographic information system subarea level analysis reveals land use type could exert different effects water quality plains mountains effects connection topographic hydrologic factors mixture land use types weather conditions field measurements well scale addition comparison correlation coefficient data buffer regions different scales indicated effect land use type inflow water quality peaked buffer regions radius whole regions within river banks key regions affected river water quality thus construction preservation riparian buffer zone regions provide considerable protection inputs non point source pollutants nutrients important function water soil conservation based pollution control zoning constructed two key pollution control zones north south phosphate rock pollution control zone northeast water loss soil erosion control zone east tourism pollution control zone west research also offers valuable insights carry subarea level prevention control water pollution regional development according natural environment land use pattern characteristics pollution sources different pollution control zones elsevier rights reserved
controversy exists regardingwhether violent shaking harmful infants absence impact study objective characterize biomechanical response infant head shaking use instrumented anthropomorphic test device commonly referred crash test dummy surrogate representing human infant improved biofidelity series tests conducted simulate violent shaking infant surrogate aprica infant surrogate represented percentile japanese newborn percentile japanese adult male recruited shake infant surrogate sagittal plane triaxial linear accelerometers positioned center mass apex head recorded accelerations shaking five shaking test series sec duration conducted outcome measures derived accelerometer recordings examined trends head neck kinematics characterized shaking events mean peak neck flexion radians degrees mean peak neck extension radians degrees maximum angular acceleration across test series radians sec chin chest contact peak angular velocity radians sec chin chest contact acceleration pulse durations ranged using infant surrogate improved biofidelity found higher angular acceleration higher angular velocity previously reported infant surrogate shaking experiments findings highlight importance surrogate biofidelity investigating shaking
article reviews theory applications koopman modes fluid mechanics koopman mode decomposition based surprising fact discovered mezic normal modes linear oscillations natural analogs koopman modes context nonlinear dynamics pursue analogy one must change representation system state space representation dynamics governed linear koopman operator infinite dimensional space observables whereas koopman original paper dealt measure preserving transformations discussion predominantly dissipative systems arising navier stokes evolution analysis based spectral properties koopman operator aspects point continuous parts spectrum discussed point spectrum corresponds isolated frequencies oscillation present fluid flow also growth rates stable unstable modes continuous part spectrum corresponds chaotic motion attractor method computation spectrum associated koopman modes discussed terms generalized laplace analysis applied generic observable method uncovers full point spectrum computational alternative given arnoldi type methods leading called dynamic mode decomposition discuss connection differences two methods number applications reviewed decompositions type pursued koopman mode theory unifies provides rigorous background number different concepts advanced fluid mechanics including global mode analysis triple decomposition dynamic mode decomposition
research revealed passive social network site sns use might undermine subjective well however less known mediating moderating mechanisms underlying relationship current study tested mediation effect envy association passive sns use low subjective wellbeing whether mediating process moderated gender sample chinese university students mean age years completed anonymous questionnaires regarding passive sns use envy subjective well results revealed association passive sns use low subjective well mediated envy moreover mediating effect envy moderated gender effect stronger females findings contribute understanding passive sns use predict low subjective well suggest need take gender account prevention intervention programs problematic sns use published elsevier ltd
objective part psoriasis patients musculoskeletal complaints inflammation entheses entheseal inflammation difficult assess clinical examination therefore aimed determine frequency clinically relevant ultrasound inflammation commonly assessed entheses masei madrid sonographic enthesis index primary care psoriasis patients one tender entheses methods adult primary care psoriasis patients musculoskeletal complaints tender enthesis arthritis physical examination ultrasound examination seven entheses according masei clinically relevant ultrasound inflammation defined active inflammation ultrasound combination least one clinical feature enthesis active ultrasound inflammation contained positive power doppler signal case plantar aponeurosis increased thickness structural changes entailed calcifications enthesophytes increased thickness hypoechogeneicity indicating irregular fibre structure erosions clinically enthesis scored positive tender enthesis clinical examination reported pain history self reported pain questionnaires results primary care psoriasis patient patients tender entheses arthritis patients clinically ultrasonographically evaluated active ultrasound inflammation accompanied pain tenderness enthesis found patients common inflammation knee plantar aponeurosis structural changes observed psoriasis patients independent clinical manifestation conclusion found concurrent presence ultrasound inflammatory changes clinical symptoms primary care psoriasis patients tenderness one entheseal sites
marriage continues fundamental institution sexual social relations forged however little known ways young men think negotiating personal relational identities within formalised institution marriage article focuses african male university students theories power performativity used understand projections masculinity within future marriage young men gender role expectations ways plan conform attempt disrupt traditional patriarchal messages marriage goals explored gender power inequities patriarchal south africa politically culturally perpetuated social inequality embedded implicated high degree interpersonal violence projected roles husbands fathers men hold many reject violence show power positive indication men questioning reworking gender norms condone accept violence women normal intentions subvert masculinities privileged patriarchal gender discourses thereby redefine gender configurations within intimate relations contemporary society viewed perceived tensions upholding traditional conceptions gender roles men resistances buttressed dominant heterosexual norms feel benefit leading ambiguity relationships
research presented paper concerns design construction testing electrical generator intended interface mems internal combustion wankel engine engine generator integrated single unit utilizing engine rotor generator rotor design allows thermal insulation stator combustion chamber simple assembly engine generator excellent utilization copper generator winding majority generator structure built discrete millimeter scale components rotor microfabricated prototype construction testing described peak open circuit voltage maximum power output reported
clippers chronic lymphocytic inflammation pontine perivascular enhancement responsive steroids steroid sensitive steroid dependent brainstem inflammatory disease unknown origin since first description cases reported throughout world mean age onset years men seem frequently affected patients without chronic corticosteroid therapy immunosuppressive agents disease relapsing remitting course mean annualized relapse rate attacks although clinical radiological improvement high doses corticosteroids systematically observed patients could display subsequent disability hindbrain atrophy since progressive course observed clinical radiological sequelae correlated previous severe attacks therefore maintaining disease remission may prevent accumulation disability literature relapse occurred chronic corticosteroid therapy maintained per day however steroids side effects led propose corticosteroid sparing therapies unfortunately controlled therapy studies clippers performed yet therapeutic recommendations exist using pubmed database articles following keywords chronic lymphocytic inflammation pontine perivascular enhancement responsive steroids clippers analysed considering mean annual relapse rate relapse occurred corticosteroid therapy maintained per day therapeutic efficiency corticosteroid sparing agents considered probable patients relapse free period months absence concomitant corticosteroid therapy corticosteroid sparing agents whose efficiency probable methotrexate two cases cyclophosphamide one case hydroxychloroquine one case considering risk benefit ratio corticosteroid sparing agents methotrexate seems suitable nevertheless randomized controlled trials testing different corticosteroid sparing agents clippers necessary
aim longitudinal study determine whether fluid reasoning plays significant role acquisition mathematics skills beyond effects cognitive numerical abilities using longitudinal cohort sequential design examined measured three assessment occasions spaced approximately years apart predicted math outcomes group participants ages years across three assessment occasions used structural equation modeling sem examine direct indirect relations children previous cognitive abilities future math achievement model including age vocabulary spatial skills accounted variance future math achievement model significant predictor future math achievement age vocabulary spatial skills significant predictors thus predictor future math achievement across wide age range spanned primary school secondary school findings build cattell conceptualization scaffold learning showing domain general ability supports acquisition rudimentary math skills well ability solve complex mathematical problems elsevier inc rights reserved
paper presents variable transformation strategy enriching variables information content defining project target actual data mining applications based relational databases data different grains actual solution assessing schools quality based official school survey students tests data variables student teachers grains become features schools belonged formal problem summarize relevant information content attribute distributions summarizing concepts features instead typical lowest order distribution momenta proposed transformations based distribution histogram produced weighted score input variables following crisp method problem interpretation precisely defined binary decision problem granularly transformed student grade proposed granular transformation embedded additional human expert knowledge input variables school level logistic regression produced classification score good schools auc roc max assessed score performance statistically independent datasets fold cross validation experimental procedure showed domain driven data mining approach produced statistically significant improvement confidence level usual distribution central tendency approach
background identification bioactive standard chemicals major challenge study chinese medicinal formula particular chemical components may interact differently depending preparative methods therefore affecting amounts bioactive components pharmacological properties medicinal formula use erxian decoction exd study model well known chinese medicinal formula treating menopausal symptoms novel rapid approach seeking standard chemicals established differentially comparing hplc profiles menopause related biochemical parameters combined decoction exd exd mixtures decoctions individual herbs exd methods levels six chemicals exerted actions hpo axis measured exd exd hplc twelve month old female sprague dawley rats employed treated exd exd endocrine functions treatment evaluated determining ovarian mrna levels aromatase key enzyme estradiol biosynthesis effect antioxidant regimen determined hepatic superoxide dismutase sod catalase cat glutathione peroxidase gpx mrna levels results amounts mangiferine ferulic acid jatrorrhizine palmatine exd twofold higher exd exd effective stimulating ovarian aromatase expression antioxidant enzymes compared exd conclusion mangiferine ferulic acid jatrorrhizine palmatine suitable use standard chemicals quality evaluation exd according approach exd could effective exd
background women conceiving following invitro fertilization ivf likely variety risk factors predispose gastroesophageal reflux disease gerd future objective aimed investigate whether pregnancy ivf may predispose subsequent gerd compared pregnancies without ivf also evaluate whether twin ivf pregnancies lead additional risk gerd compared singleton ivf pregnancies methods validated reflux questionnaire administered women singleton twin ivf birth ivf group women naturally conceived singleton birth control group women included study primiparas given birth least year prior data collection diagnosis gerd based occurrence typical symptoms heartburn regurgitation least week results prevalence gerd ivf control groups ivf group slightly higher statistically significant women twin compared singleton pregnancies logistic regression analysis showed ivf strongly associated subsequent gerd conclusion risk developing gerd least year delivery increased following ivf long term follow studies required determine whether therapy pregnancy prevent risk
data interleukin involvement patho genesis mastocytosis impact pruritus development disease limited aim study analyse distinct gene polymorphisms patients age years mastocytosis correlation clinical presentation pruritus serum levels patients mastocytosis frequency ivs genotype ivs allele higher control subjects linked increased risk development mastocytosis adult patients children genotype also associated increased risk occurrence mastocytosis pruritus affected adult patients mastocytosis positive correlation serum levels pruritus found patients conclusion distinct polymorphic variants gene may involved pathogenesis mastocytosis may involved induction pruritus patients mastocytosis
ich guideline describes consistent approach identify categorize control dna reactive mutagenic impurities pharmaceutical products limit potential carcinogenic risk related impurities paper outlines series principles procedures consider generating sar assessments aligned ich guideline included regulatory submission absence adequate experimental data results two complementary sar methodologies may combined support initial hazard classification may followed assessment additional information serves basis expert review support refute predictions paper elucidates scenarios additional expert knowledge may beneficial expert review may contain results accompanying considerations may documented furthermore use principles procedures yield consistent robust sar based argument support impurity qualification regulatory purposes described manuscript authors published elsevier inc
phylogenetic likelihood function plf major computational bottleneck several applications evolutionary biology phylogenetic inference species delimitation model selection divergence times estimation given alignment tree evolutionary model parameters likelihood function computes conditional likelihood vectors every node tree vector entries input data identical result redundant likelihood operations turn yield identical conditional values operations omitted improving run time using appropriate data structures reducing memory usage present fast novel method identifying omitting redundant operations phylogenetic likelihood calculations assess performance improvement memory savings attained method using empirical simulated data sets show prototype implementation method yields fold speedups uses less memory one fastest highly tuned implementations plf currently available method generic seamlessly integrated phylogenetic likelihood implementation
water footprint accounting proposed water footprint network wfn potentially provide important information water resource management especially water scarce countries relying irrigation help meet food requirements however calculating accurate wfs short season vegetable crops carrots cabbage beetroot broccoli lettuce presented challenges planting dates inter annual weather conditions impact results joining weather datasets rainfall minimum maximum temperature ones include solar radiation wind speed affected crop model estimates results functional unit selected also major impact results example wfs according wfn approach account crop residues used purposes like composting animal feed using yields dry matter rather fresh mass also impacts metrics making comparisons difficult overcome using nutritional value crops functional unit connect water use directly potential benefits derived different crops allow straightforward comparisons grey wfs based nitrogen disregards water pollution caused phosphates pesticides salinization poor understanding fate nitrogen complicates estimation nitrogen loads aquifer
aim study present method using computer aided design computer aided manufacturing cad cam surgical guides accurately obtain desired bone reduction followed immediate implant placements loading patients diagnosed terminal dentition patients bone reduction implants placed immediate loading using anatomage invivo cad cam surgical guides period evaluated retrospectively patients diagnosed terminal dentition treated using guide technique identified pre postsurgical images superimposed evaluate deviations bone reduction deviations crest apex angle implants placed twenty six implants placed patients included study overall deviation means measured bone reduction overall deviation means measured implant placement crest apex angle degrees respectively cad cam surgical guide fabrication emerging tool may facilitate surgical process aid safe predictable execution bone reduction immediate implant placement using cad cam surgical guides method presented obtain desired bone reduction followed immediate implant placement loading patients diagnosed terminal dentition method may improve guide stability patients terminal dentition undergoing complete implant supported treatment taking advantage teeth extracted
pharmacokinetics apremilast major metabolite evaluated subjects varying degrees renal impairment men women renal impairment estimated glomerular filtration rate min mild min moderate min severe demographically healthy matched control subjects received single oral dose apremilast plasma apremilast metabolite concentrations determined pharmacokinetic parameters calculated samples obtained predose hours postdose subjects mild moderate renal impairment apremilast pharmacokinetic profiles similar healthy matched subjects subjects severe renal impairment apremilast elimination significantly slower exposures based area plasma concentration versus time curve time zero extrapolated infinity maximum observed plasma concentration increased versus healthy matched subjects metabolite pharmacokinetic profiles subjects mild renal impairment similar healthy matched subjects however increased moderate severe renally impaired subjects dose reduction apremilast recommended individuals severe renal impairment mild moderate renal impairment
introduce novel procedure uses dynamic computer graphics diagnostic tool assessing disease severity schizophrenia patients based reduced influence top cognitive processes interpreting bottom sensory input procedure uses hollow mask illusion concave side mask misperceived convex familiarity convex faces dominates sensory cues signaling concave mask known schizophrenia patients resist illusion resistance increases illness severity method uses virtual masks rendered two competing textures realistic features enhance illusion random dot visual noise reduces illusion control relative weights two textures obtain psychometric functions controls patients assess illness severity primary novelty use rotating mask easy implement wide variety portable devices avoids use elaborate stereoscopic devices used past thus method also used assess efficacy treatments provides clinicians advantage bring test patient environment instead bring patients clinic
injury major setback sportsmen women elite athletes spurred research primarily focused physical recovery treatment psychological resilience plays crucial role recovery order assess prevalence injuries strategies coping used elite athletes recover injuries kayakists men women registered spanish national championship assessed participants answered questionnaire sports injuries athletic coping skills inventory crocker results revealed probability suffering sports injury significant similar different stages training athletes adopt one coping style combination adaptive maladaptive strategies maintenance stage performance gains athletes resort fewer maladaptive strategies male kayakists use different strategies female kayakists cope injury results lend support lazarus folkman model implications intervention discussed
clinical depression affects physicians including radiologists medical professionals including radiologists may comfortable treating patient one psychiatric issues may regarded taboo discussion issue clinical depression specialty subspecialty received widespread attention specifically review national international literature pubmed scopus google reveals publications dedicated issue clinical depression radiology although statistically must exist purpose report define terms describe manifestations scope issues related clinical depression special attention given risk factors unique radiologists working low ambient light near different fields magnetic strength end article authors hope reading radiologist aware open possibility clinical depression colleague within clinical depression common important get help
aim assess impact underlying liver disease etiology presenting features outcomes large cohort patients hepatocellular carcinoma hcc methods prospective database patients hcc established march one thousand seventy eight patients categorized three groups based etiology liver disease hepatitis virus hbv hepatitis virus hcv non viral liver disease nvld overall survival determined kaplan meier analysis time death last follow results hcc patients hcv likely diagnosed part surveillance program compared hbv nvld patients nvld likely receive best supportive care compared hbv hcv twelve percent nvld hbv patients underwent liver transplantation compared hcv patients median survival presentation lowest nvld years compared hbv years hcv years multivariate analysis independent predictors survival included child turcotte pugh score size dominant lesion absence vascular invasion management surgical resection liver transplantation patient age etiology underlying liver disease independent predictors survival conclusion patients nvld hcc less likely enrolled hcc surveillance program less likely curative therapies liver resection transplantation diagnosis hcc compared patients hepatitis hepatitis
several frequency compensation schemes proposed stabilize multistage amplifiers negative feedback performance amplifiers analyzed inspecting inputoutput transfer function representation frequency response many circuit elements affecting output response relatively difficult obtain real transfer function multistage amplifiers based original small signal expressions instead certain techniques miller theorem used approximate important parameters gain dominant pole methods generally helpful approximating nondominant poles critical role loop stability nano scale amplifiers issue mind work proposes systematic methodology achieve pole expressions multistage amplifiers frequency compensation key proposed technique model equivalent impedance compensation loop output effectiveness proposed approach verified comparison transfer functions obtained theory transfer functions found literature elsevier gmbh rights reserved
paper addresses problem finding credible sources among twitter social network users detect prevent various malicious activities spreading false information potentially inflammatory topic forging accounts false identities etc existing research works related source credibility graph based considering relationships among users predict spread information human based using human perspectives determine reliable sources machine learning based relying training classifiers predict users credibility approaches consider user sentimentality analyzing credibility source paper propose novel approach combines analysis user reputation given topic within social network well measure user sentiment identify topically relevant credible sources information particular propose new reputation metric introduces several new features existing models evaluated performance proposed metric comparison two machine learning techniques determining accuracy proposed approach satisfies stated purpose identifying credible twitter users copyright john wiley sons ltd
background idiopathic intracranial hypertension iih associated obesity obesity associated binge eating disorder bed aim paper address presence impact bed patients undergoing iih diagnostic protocol methods cross sectional study consecutive patients suspected iih underwent neurological neuroophthalmologic psychological examinations neuroimaging studies intracranial pressure icp measurements lumbar puncture recumbent position iih diagnosis based international classification headache disorders edition criteria bed diagnosis based diagnostic statistical manual mental disorders edition criteria presence oligoclonal bands ocbs cerebrospinal fluid also assessed results forty five patients enrolled diagnosed iih five obese bed compared non obese patients obese particularly obese bed likely iih diagnosis chi icp mmh chi history abuse neglect chi association ocbs found conclusions reported first time presence bed among patients iih showed bed associated iih icp history abuse neglect
objective identify areas deficiencies gaps child protection services northern sri lanka also help recommending strategies programmes interventions addressing issues child abuse advice legal system methods retrospective study done determine socio demographic details type abuse clinical profile relationship perpetrator nature abuse among children admitted tertiary care centre period cessation conflict data obtained hospital based records records maintained district probation office results seven hundred twenty cases referred tertiary care centre abuse majority children jaffna district northern city war affected area mean age children affected females affected males children seen following sexual abuse clinical examination showed penetrative injury perpetrator known situations victim coerced relationship abuse attempted suicide seen significant numbers immediate post war period school dropout delinquent behaviour seen later years conclusions problem child abuse considerable region urgent need strengthen services offered victims urgent steps needed safeguard children especially war affected areas
mesh based magnetic equivalent circuit derived model dynamics wound rotor synchronous machines wrsms particular focus placed derivation flux tubes model machines arbitrary number damper bars placed arbitrary depth rotor pole tip faraday law applied establish state model winding damper bar flux linkages selected state variables resulting coupled magnetic equivalent circuit state model solved predict machine dynamics important attribute model saturation represented without need relaxation factor enables use practical tool machine design data obtained hardware experiment finite element model used validate proposed methods
commercial organisations invested greening buildings concerned reducing negative impact buildings environment also potential positive impact green buildings employees therefore also financial sustainability organisation date research evidence effect green buildings employees equivocal widely varying research designs measures differing research foci resulted fragmented contradictory body knowledge study attempt bring order field first providing framework reviewing evaluating extant research evidence second starting address research design flaws identified previous research longitudinal empirical investigation impact green building employees empirical study three green buildings evaluated using pre test post test design repeated measures design contrast group two buildings total statistical analyses data established significant improvements perceived air quality across three buildings significant improvements self report productivity two buildings significant improvement physical wellbeing one building however significant differences found psychological wellbeing job satisfaction propensity leave organisation organisational image consider results methodologically robust suggest caution interpreting results due poor response rates possible volunteer bias results discussed relation design features building elsevier ltd rights reserved
hidden suspicious accounts sparsely connected social graphs however certain suspicious messages usually forwarded bulk extend overall propagation scope existing anti attack methods detect single messages accounts algorithms rely connection relations among accounts social graphs may repeatedly detect account furthermore hidden suspicious accounts identified eliminated completely therefore messages forwarded hidden suspicious accounts merged accounts eliminated simultaneously rather individually paper introduces forwarding message tree combines accounts based relations among forwarded messages approach clearly exposes inner relations among hidden suspicious accounts conveniently deletes accounts first present forwarding message tree identify six effective features forwarding layer relation propagation depth propagation breadth repeated forwarding behavior propagation speed average tree weight next illustrate effectiveness features incorporate machine learning algorithms detection accuracy false positive rates real dataset collected online social network respectively proposed features rate top gain ranking conclude forwarding message tree indeed detect delete hidden suspicious accounts elsevier inc rights reserved
video object tracking represents important computer vision domain paper perceptual hashing based template matching method object tracking proposed efficiently track objects challenging video sequences tracking process first apply three existing basic perceptual hashing techniques visual tracking namely average hash ahash perceptive hash phash difference hash dhash compared previous tracking methods mean shift compressive tracking perceptual hashing based tracking outperforms terms efficiency accuracy order improve accuracy object localization robustness tracking propose laplace based hash lhash laplace based difference hash ldhash qualitative quantitative comparison representative tracking algorithms experimental results show improved perceptual hashing based tracking algorithms perform favorably state art algorithms various challenging environments terms time cost accuracy robustness since improved perceptual hashing compact efficient representation objects applied fusing depth information robust rgb video tracking
present study aims investigate interplay verbal nonverbal communication respect infants perception pointing gestures infants presented still images pointing hands cue combination acoustic stimulus communicative content acoustic stimulus varied human communicative artificial saccadic reaction times srts cue peripheral target measured indicator modulation covert attention significant cueing effect facilitated srts congruent compared incongruent trials present condition additional communicative referential speech addition size cueing effect increased human communicative acoustic stimulus indicates beneficial effect verbal communication perception nonverbal communicative pointing gestures emphasizing important role verbal communication facilitating social understanding across domains findings additionally suggest human communicative ostensive signals qualitatively different less social signals quantitatively attention grabbing among number signals
cracks formed drying process spaghetti production reduces commercial value quality hence important detect cracks manufacturing process dried spaghetti however presence mottles originating wheat bran hinders automatic identification cracks study developed simple method detect cracks induced spaghetti using digital camera cracks mottles distinguished pixelating transmission light image spaghetti analyzing image based geometric characteristics histogram consisting pixels method able detect cracks induced spaghetti rough surface prepared via bronze die using vacuum extrusion molding well induced spaghetti smooth surface prepared using teflon die
ethnopharmacological relevance perilla frutescens britt lamiaceae traditional herb consumed east asian countries traditional medicine traditional herb documented centuries treat various diseases depression allergies inflammation asthma however effect perilla frutescens skin characterized well aim study present study aimed investigate effect perilla frutescens leaves extract ple ultraviolet radiation induced extracellular matrix damage human dermal fibroblasts hairless mice skin materials methods human dermal fibroblasts skh hairless mice irradiated treated ple protein mrna levels various target molecules analyzed western blotting quantitative pcr respectively histological changes mouse skin analyzed staining elucidate underlying mechanism ple activator protein dna binding assay measurement reactive oxygen species ros performed results ple significantly inhibited basal induced mmp mmp expression dose dependently also decreased induced phosphoryla lion extracellular signal regulated kinases jun terminal kinases inhibitory effects ple mmp mmp mediated reduction ros generation dna binding activity induced furthermore ple promoted type procollagen production irrespective irradiation irradiated animal model ple significantly reduced epidermal skin thickness mmp expression induced conclusion results demonstrate ple protective effect induced dermal matrix damage therefore suggest ple potential agent prevention skin aging
standard solution methods dsge models necessarily deliver minimal state space forms abcd form non minimal conditions literature necessary existence var representation observables paper present necessary sufficient conditions valid general hence applied minimal non minimal abcd forms state space form minimal conditions coincide literature results also clarify possible unstable eigenvalues together possibly finite var representation observables
assess relationship carriage apoe epsilon allele evolution white matter hyperintensities wmhs volume longitudinally studied subjects alzheimer disease neuroimaging initiative cohort diagnoses ranging normal controls probable alzheimer disease purpose built longitudinal automatic method used segment wmh using constraints derived atlas based model selection applied time averaged image linear mixed models used evaluate differences rate change across diagnosis genetic groups adjustment covariates age sex total intracranial volume homozygous apoe epsilon epsilon subjects significantly higher rate wmh accumulation per year standardized population typical values covariates compared heterozygous epsilon epsilon subjects per year homozygous per year subjects rates accumulation increased diagnostic severity controls accumulated per year standardized population early mild cognitive impairment per year late mild cognitive impairment per year subjects per year following adjustment apoe status differences became nonstatistically significant suggesting apoe epsilon genotype major driver accumulation wmh volume rather diagnosis author published elsevier inc open access article license
cryptococcus neoformans opportunistic fungal pathogen important cause morbidity mortality immunocompromised patients report case osteomyelitis caused neoformans liver transplant recipient presented headache scalp lump sustaining mild head trauma evidence central nervous system involvement dissemination first known case report isolated cryptococcal osteomyelitis liver transplant recipient
objective research eating disorders eds suggests outcome variables per presence comorbid disorders overall functioning follow may influence condition time sought assess factors potentially predicting different outcome variables methods eighty eight female adolescent patients assessed admission discharge around one year post discharge using clinical interviews self rating questionnaires assessing relevant symptoms results mean body mass index bmi patients anorexia nervosa increased admission discharge maintained follow twenty eight patients remitted follow whereas patients intermediate poor related outcome respectively follow bmi correlated baseline bmi good related outcome follow according accepted criteria associated lifetime suicide attempts severe baseline symptomatology elevated psychiatric comorbidity follow associated elevated baseline anxiety hospitalisation post discharge follow period better academic occupational functioning social functioning follow associated less lifetime suicide attempts less hospitalisation lower baseline anxiety conclusions eds diverse factors may predict different outcome variables
study design cross sectional objective describe physical activity level fracture rates adults idiopathic scoliosis diagnosed maturity compare control group summary background data previous study found lower level sporting activities adults treated idiopathic scoliosis compared controls studies shown lower bone mass adults idiopathic scoliosis compared controls methods one thousand two hundred seventy eight adults aged idiopathic scoliosis controls aged included answered international physical activity questionnaire short form ipaq questions previous fractures three scoliosis treatment groups untreated brace surgically treated compared furthermore comparison based onset juvenile adolescent performed achieved weekly moderate activity level metabolic equivalent task met minutes week assessed patients controls statistical comparisons made analysis covariance adjustments age body mass index sex results proportion achieving weekly moderate activity level individuals idiopathic scoliosis controls scoliosis patients reported met minutes week median value controls fracture rates differ fewer surgically treated individuals achieved moderate activity level compared untreated previously braced individuals difference seen regarding met minutes week differences seen individuals juvenile onset compared individuals adolescent onset conclusion adults idiopathic scoliosis similar physical activity level sustain fractures compared controls adults surgically treated idiopathic scoliosis slightly lower physical activity level previously braced untreated patients onset idiopathic scoliosis affect physical activity level
background evidence suggests times increase risk violent behavior schizophrenia compared general population current theories propose processing negative emotions defective violent individuals dysfunctions within neural circuits involved emotion processing implicated violence although schizophrenia patients show enhanced sensitivity negative stimuli functional neuroimaging studies examined emotion processing among men schizophrenia history violence objective present study aimed identify brain regions greater neurofunctional alterations detected functional magnetic resonance imaging emotion processing task men schizophrenia engaged violent behavior compared methods sixty men studied schizophrenia history violence schizophrenia violence healthy men scanned viewing positive negative neutral images results negative images elicited hyperactivations anterior cingulate cortex acc left right lingual gyrus left precentral gyrus violent men schizophrenia compared nonviolent men schizophrenia healthy men neutral images elicited hyperactivations right left middle occipital gyrus left lingual gyrus left fusiform gyrus violent men schizophrenia compared two groups discussion violent men schizophrenia displayed specific increases acc response negative images given role acc information integration results indicate specific dysfunction processing negative emotions may trigger violent behavior men schizophrenia
substitution boxes boxes play important role many modern day cryptographic algorithms commonly known ciphers without carefully chosen boxes ciphers would easier break therefore surprising design suitable boxes attracts lot attention cryptography community evolutionary computation community also several attempts using evolutionary paradigms evolve boxes good cryptographic properties article focuses fitness function one use evolving highly nonlinear boxes extensive experimental analysis current state art fitness functions present new one offers higher speed better results compared aforementioned fitness functions
introduction bim technology traditional construction project management model innovation realize data sharing common platform participate many units construction project management convenient effective due long engaged technology research development application bim construction management future construction project management bim technology sharing exchange construction schedule cost quality safety control application bim construction simulation construction green bim application people machine material method central management bim applications
big data popular areas computer science commerce bioinformatics early stage hydroinformatics big data originated extremely large datasets processed tolerable elapsed time traditional data processing methods using analogy object oriented programming big data considered objects encompassing data characteristics processing methods hydroinformatics benefit big data technology newly emerged data techniques analytical tools handle large datasets creative ideas new values could mined paper provides timely review big data relevance hydroinformatics exploration precipitation big data discussed estimation precipitation important part hydrology managing floods droughts understanding global water cycle promising fusion precipitation data remote sensing weather radar rain gauge numerical weather modelling could achieved parallel computing distributed data storage trigger leap precipitation estimation available data multiple sources could fused generate better product single sources
background purpose known post transplant graft function deceased donor liver transplantation living donor liver transplantation ldlt differ however report assessing relationship graft function development new onset diabetes mellitus transplantation nodat conducted study identify predictive risk factors nodat including graft function ldlt methods subjects study adult recipients underwent ldlt kyoto university hospital survived months median observation period days results year incidences nodat ldlt respectively pre transplant diabetes associated poor survival whereas nodat associated patient survival multivariate analysis recipient age tacrolimus trough level months ldlt cholinesterase che months ldlt independent risk factors nodat conclusions poor graft synthetic function months ldlt well older age recipient higher tacrolimus concentration strongly associated nodat development ldlt
die model characterized high design efficiency strong correlation plays important role simulation machining complexity structure changing shape flow channel current design tools lack level automation design extrusion die nontrivial task paper integral design method proposed improve design efficiency model correlation computer aided design cad system plastic profile extrusion die designed implemented integrating visual studio unigraphics closed loop recognition algorithm clr multi closed loops intelligent recognition mclr algorithm multi closed loops matching mclm algorithm based feature recognition proposed realize automatic generation ruled surface flow channel integral design automatic generation methods die set proposed facilitate efficient formation different structures process holes particle swarm optimization pso algorithm put forward obtain best position specification interference parts three modules integral sketches integral flow channel integral die set developed focus integrating proposed automation design methods framework case application die design used illustrate proposed method results show developed cad system improves design efficiency extrusion die also enhances design quality
bonobo pan paniscus one endangered primate species context bonobo species survival plan milwaukee county zoo established successful breeding group although bonobo serves model species human evolution prenatal growth described detail develop growth graphs animals milwaukee county zoo trained positive reinforcement allow ultrasound exams without restraint method well mother fetus maintained ultrasound exams could performed frequently ovulation date four animals study determined exactly gestational age known examination measurements biparietal diameter bpd head circumference abdominal circumference femur length used create growth curves prenatal growth paniscus compared data humans common chimpanzee troglodytes respect cranial structures bpd humans significant acceleration growth compared paniscus troglodytes paniscus growth similar throughout pregnancy whereas humans reaches level close term growth rate similar humans two pan species near day post ovulation pan species growth slowed compared human newly developed fetal growth curves paniscus assist monitoring prenatal development predicting birth dates highly endangered species zoo biol wiley liss inc
last century industrialization agriculture consumption fossil fuels resulted significant imbalance redistribution nitrogen containing resources sparked interest developing sustainable resilient approaches producing nitrogen containing commodities fertilizers fuels one largely neglected emerging approach photocatalytic nitrogen fixation significant evidence process occurs spontaneously terrestrial settings demonstrated numerous engineered systems yet many questions still remain unanswered regarding rates mechanisms impacts photocatalytically producing fixed nitrogen thin air work reviews fascinating history reaction examines current progress toward understanding improving photofixation nitrogen supplemented quantitative review thermodynamic considerations limitations various reaction mechanisms finally future prospects preliminary performance targets photocatalytic nitrogen fixation discussed
background children health programs sub saharan africa always oriented primarily infectious diseases malnutrition witnessing early century epidemiological transition marked decline old diseases identification new diseases including heart disease therefore necessary describe spectrum diseases order better prepare health workers new challenges methods conducted cross sectional study focused heart disease diagnosed echocardiography children seen january december pediatric hospital yaounde collected socio demographic data types heart disease registers patients files well electronic database echocardiographic records results total patients underwent echocardiographic examination study period including subjects heart disease congenital cardiopathies found patients acquired abnormalities seven children combination types congenital heart defects chd dominated ventricular septal defect vsd acquired heart disease mostly rheumatic valvulopathies dyspnea exertion frequent presenting complaint discovery heart murmur principal clinical finding physical examination median age months congenital heart disease months acquired heart disease conclusions infectious diseases recede diagnostic facilities improving pediatric heart diseases occupy important position spectrum pediatric diseases context however ability evoke diagnosis remains unsatisfactory majority health personnel therefore needs improved apart congenital heart diseases impact acquired heart diseases rheumatic valvulopathy highest ranking remarkable pediatrics awareness health personnel better management child tonsillitis ever necessity preventive attitude rheumatic heart disease main attitude available disadvantaged economic environment
background historically acute hepatitis virus hcv infection treated shorter durations interferon containing therapies era direct acting antivirals daas unclear whether efficacy treatment achieved chronic infection maintained abbreviated courses therapy acute phase methods sofosbuvir containing regimens without interferon treatment acute hcv hiv infected individuals swift open label cohort clinical trial first cohort assessed safety efficacy weeks sofosbuvir plus ribavirin treatment acute hcv infection participants chronic human immunodeficiency virus type hiv infection preplanned analysis first cohort planned accrual participants results seventeen men hispanic white median age years enrolled hcv genotype infection favorable ilb genotype median baseline hcv rna interquartile range ten participants achieved primary outcome svr confidence interval failing establish noninferiority treatment failures due viral relapse premature treatment discontinuations factor differed participants achieved svr relapsed ribavirin concentration end treatment conclusion sofosbuvir ribavirin weeks treatment acute hcv genotype infection hiv infected persons results high relapse rate preliminary studies daa combination therapies suggest improved response rates although adequate duration therapy remains unclear
background proton pump inhibitors ppis lead several adverse effects among elderly particularly used inappropriately contrast evidence suggested protocols objective aim study examine prevalence predictors non evidence based ppi use elderly nursing home residents methods cross sectional study conducted using data national nursing home survey nnhs study sample included nursing home residents years older descriptive statistics used examine prevalence non evidence based ppi use multivariable logistic regression used evaluate patient facility level factors associated non evidence based ppi use among elderly nursing home residents results total elderly nursing home residents received least one ppi overall prevalence among elderly receiving ppis use evidence based multivariable logistic regression revealed residents osteoporosis odds ratio ssri users residing micropolitan area negatively associated prescription ppis without indication patients chronic cough medicare insurance positively associated prescription ppis without indication conclusions current study found almost half elderly nursing home residents used ppi non evidence based indications given safety concerns high non evidence based use ppi nursing homes urgent need optimize ppi use elderly elsevier inc rights reserved
use mobile devices including smartphones tablets smart watches notebooks increasing day day societies usually connected internet offer nearly functionality memory speed like get benefits mobile devices applications installed advance applications available third party websites google play store etc existing mobile devices operating systems android easy attack open source environment android use open source facilty attracts malware developers target mobile devices new malicious applications botnet capabilities mobile botnet one crucial threat mobile devices study propose static approach towards mobile botnet detection technique combines permissions broadcast receivers well background services uses machine learning algorithm detect applications capabilities mobile botnets technique given features extracted android applications order build machine learning classifier detection mobile botnet attacks initial experiments conducted known recently updated dataset unb iscx android botnet dataset combination different malware families shows efficiency approach given research progress
work performance mussel shell aggregate plain concrete studied mussel shell used came cannery industry produces million tonnes shell product year worldwide mussel shell heat treated degrees min crushed sieved sand gravel new aggregates studied ray diffraction xrd tga sem microscopy two different conventional concretes designed non structural concrete nsc plain structural concrete natural aggregates sand gravel sand gravel replaced mussel shell aggregates different percentages concretes characterized fresh hardened states microstructure workable life progression workability compressive splitting strength longitudinal modulus elasticity weight loss water permeability results lead establishing treatment mussel shell replacement limited fine coarse aggregates fine coarse aggregates percentages nsc display correct behaviour elsevier ltd rights reserved
optical sampling scheme using single semiconductor optical amplifier proposed analog signal processing analog optical signal sampled probe pulse train nonlinear polarization rotation arising semiconductor optical amplifier conversion efficiency total harmonic distortion presented evaluate sampling linearity experiment gsa optical sampling ghz analog optical signal successfully demonstrated commercially available fiber pigtailed components results show fundamental conversion efficiency total harmonic distortion operating power respectively proposed optical sampling requires one semiconductor optical amplifier low power consumption simple potential photonic integration elsevier rights reserved
inspired sociolinguistic scholarship study examines influence linguistic vitality social health language perceived group threat group attitudes using experimental design manipulated perceptions linguistic vitality french quebec study sought ascertain causal role linguistic vitality intergroup attitudes results demonstrate type information positive negative linguistic vitality influences perceptions threat towards language however results linguistic vitality information impact group attitudes support independence subjective identity revealed inter individual heterogeneity
purpose predictive factors long term outcome situ fixation chronic slipped capital femoral epiphysis scfe far systematically analysed aims study define predictors long term outcome assess association initial grade slipping post slip deformities methods studied patients hips chronic scfe treated situ fixation males females mean age years mean follow years post slip deformity defined abnormal alpha alpha angles anteroposterior lateral radiographs angle degrees lateral angle degrees used cutoffs normal abnormal alpha angles harris hip score hhs less points classified poor clinical outcome osteoarthritis poor radiographic outcome results mean slip angle degrees degrees degrees mean alpha angle degrees degrees degrees mean lateral angle degrees degrees degrees post slip deformities developed almost one third hips mild degree slipping half hips pronounced degrees slipping long term outcome good hips poor hips small alpha angle independent prognostic factor good combined clinical radiographic outcome conclusion post slip deformity defined abnormally high alpha angle important prognostic factor poor long term clinical radiographic outcome chronic scfe treated situ fixation
known objectivesthe safety continued ustekinumab ust therapy pregnancy remains unclear patients crohn disease meta analysis reports exposure ust pregnancy objective describe case pregnant patient successfully treated ust maintenance therapy throughout pregnancy delivered baby boy without congenital malformations neurological abnormalities birth defects case summarya year old patient treated ust became pregnant receiving ust months time discussion patient obstetric team ust therapy continued result treatment uneventful pregnancy delivery term healthy boy maintenance clinical biological endoscopic remission pregnancy new conclusionto knowledge first reported use continued ust therapy throughout pregnancy result treatment uncomplicated pregnancy mother giving birth healthy boy term maintenance clinical biological endoscopic remission pregnancy
interpreting results functional analysis clinician may conclude automatic function either problem behavior elevated alone ignore condition relative conditions problem behavior elevated undifferentiated across multiple conditions latter difficult determine problem behavior maintained automatic reinforcement alone multiply maintained current study tested multiply maintained self injurious behavior exhibited two participants implementing functional analysis contingencies controlling automatic reinforcement sensory extinction results suggest self injury maintained automatic reinforcement alone one participant automatic reinforcement physical attention another participant results used create function based treatments self injury successfully generalized across settings caregivers
study examines social estrangement factors associated forms income generation used homeless young adults formal sources full time part time temporary employment informal sources selling personal possessions selling drugs theft prostitution combination formal informal sources sample homeless young adults recruited cities los angeles austin denver participate semi structured interviews multinomial logistic regression model used assess whether demographic homelessness history arrest history transience peer substance use antisocial personality disorder substance use disorder variables predict involvement forms income generation compared participants report work related income homeless young adults earn income formal sources differentiated report work related income variables gender primary residence earn income via informal sources differentiated homeless young adults report work related income variables age city primary residence transience peer substance use antisocial personality disorder participants earn income combination formal informal sources distinguished report work related income variables gender city primary residence transience peer substance use antisocial personality disorder substance use disorder study findings suggest might value combining supportive housing employment clinical services population
new active element analog signal processing namely current inverter buffered differential input transconductance amplifier cibdita proposed combines features well known current differencing buffered transconductance amplifiers simplifies current input stage increases universality introducing additional voltage type input usefulness new element demonstrated example order filter employs one active element two grounded capacitors one resistor
paper focuses learning smooth skeleton structure noisy data emerging topic fields computer vision computational biology many dimensionality reduction methods proposed none specially designed purpose achieve goal propose unified probabilistic framework directly models posterior distribution data points embedding space suppress data noise reveal smooth skeleton structure within proposed framework sparse positive similarity matrix obtained solving box constrained convex optimization problem sparsity matrix represents learned neighborhood graph positive weights stand new similarity embedded data points obtained applying maximum posteriori estimation posterior distribution expressed learned similarity matrix embedding process naturally provides probabilistic interpretation laplacian eigenmap maximum variance unfolding extensive experiments various datasets demonstrate proposed method obtains embedded points accurately uncover inherent smooth skeleton structures terms data visualization method yields superior clustering performance compared various baselines
amount remote sensing data available applications constantly growing due rise high resolution sensors short repeat cycle satellites consequently tackling computational complexity earth observation information extraction rising major challenge resorting high performance computing hpc becoming common practice since provides environments programming facilities able speed processes particular clusters flexible cost effective systems able perform data intensive tasks ideally fulfilling computational requirement however use typically implies significant coding effort build proper implementations specific processing pipelines letter presents generic framework development images processing applications targeting cluster computing based common open source libraries leverages parallelization wide variety image processing pipelines transparent way performances typical tasks implemented using proposed framework demonstrate great potential effective timely processing large amount data
introduction provide overview urological management spinal cord injured patients based economic analysis materials methods literature search january december performed using medline embase database using following keywords cost effectiveness cost benefit cost utility spinal cord injury neurogenic bladder intermittent catheterization antimuscarinics botulinum toxin sacral neuromodulation tibial nerve brindley sphincterotomy tool used comparison qaly quality adjusted life years indicator allowing comparison two medical treatments using cost per qaly results solifenacin cost effective treatment incremental cost effectiveness ratio icer sic qaly compared trospium qaly compared trospium sic qaly compared oxybutinin botulinum toxin also cost effective icer qaly compared best supportive cares anticholinergic refractory neurogenic detrusor overactivity conclusion solifenacin botulinum toxin appears cost effective treatments spinal injured urological cares pressing need increase improve data collection research spinal cord injury elsevier masson sas rights reserved
awareness knowledge emergency contraception less among indians usually southern states india better performance family planning northern states hence andhra pradesh karnataka kerala tamil nadu considered study district level health survey data source several socio economic demographic variables considered determinants analysis revealed kerala state highest awareness followed karnataka tamil nadu lastly andhra pradesh logistic regression revealed muslims less knowledge emergency contraception christians better knowledge hindus scheduled caste tribe respondents also less knowledge emergency contraception years schooling respondents spouse also emerged important variables affecting knowledge emergency contraception
objective purpose study evaluate violence content top grossing films determine percentage potential negative effects young viewers percentage potential prosocial beneficial effects methods large multidimensional analytic instrument designed systematic coding act violence contextualization features shown either enhance protect harmful effects associated violent media exposure perpetrators victims violence motivation violence presence weapons degree realism consequences violence descriptive statistics genre performed film ordinal logistic regression model used examine association seriousness violence weapons motive genre results sample films total violent actions observed roughly half lethal magnitude total acts contained justified violence initiated major characters extremely serious approximately two thirds films rated reasons violence conclusions violence permeated nearly films study although small subset content contained violence associated negative effects film contained violence associated protective beneficial effects
paper describes methods used university west bohemia uwb recruiting students faculty mechanical engineering fme developments czech educational system past two decades also summarized methods used inform general public possibilities studying fme provide news field science new technologies developed fme described article information given activities organised faculty general public specialized events directed towards closed number potential students new learning study materials created uwb fme mentioned paper study materials contribute increasing interest study fme assist keeping students motivated studies
propagation high frequency electromagnetic waves rain affected absorption scattering lead signal attenuation satellite terrestrial super high frequency shf acid extremely high frequency ehf links many factors govern rain effects waves propagating atmosphere namely raindrop size distribution rain cumulative distribution water temperature refractive index operating frequency high degree accuracy calculation specific attenuation caused rain attenuation per importance planning high frequency radio communication systems alpha expression widely used calculations relationship represents rain rate alpha parameters determined frequency interpolation considered compromise complexity simplified approach van hulst relationship paper present new theoretical model based physical laws allowing calculation specific attenuation caused kinds hydrometeor particles high frequency electromagnetic waves method derived forward scattering amplitude van hulst relationship governed wave polarization wave incidence angle radio link operating frequency precipitation particle size distribution climate interest application gives theoretical results good agreement data gathered terrestrial earth satellite links several localities around world new proposed model easily used constitute useful tool evaluating satellite terrestrial radio link performances mainly future bring expansion high frequency satellite systems john wiley sons ltd
paper elaborate program based multi objective genetic algorithms mogas allow automated optimization analog circuits proposed methodology used find optimal transistors sizes length width order obtain operational amplifier performances analog mixed cmos based circuit applications eight performances considered study direct current gain unity gain bandwidth gbw phase margin power consumption area slew rate thermal noise signal noise ratio snr program solved using matlab optimization toolbox solvers also using variables obtained genetic algorithms operational transconductance amplifier ota simulated using cadence virtuoso spectre circuit simulator standard tsmc taiwan semiconductor manufacturing company cmos technology good agreement observed program optimization electric simulation
article presents studies association media violence rates societal violence rates first study movie violence homicide rates examined across century throughout mid century small moderate correlational relationships observed movie violence homicide rates united states trend reversed early latter century movie violence rates inversely related homicide rates second study videogame violence consumption examined youth violence rates previous decades videogame consumption associated decline youth violence rates results suggest societal consumption media violence predictive increased societal violence rates
parkinson disease widely heterogeneous disorder broad list motor nonmotor manifestations identifying subtypes parkinson disease one top clinical research priorities review aims summarize valid conventional recent subtyping solutions introduced far update current knowledge recent discoveries association subtypes disease progression also discuss challenges subtyping context parkinson disease stability subtypes time potential clinical implications sophisticated evidence show distinct subtypes parkinson disease diverging trends progression holistic view subtyping merge traditional motor features key nonmotor manifestations promising approach identify subgroups different prognosis subtyping could improve adding continuing add data imaging csf genetic biomarkers
adipokines pleiotropic molecules produced white adipose tissue wat attracted attention scientists since role adipokines metabolic syndrome known fixed adipokines exerting variety metabolic activities contributed ethiopathogenesis consequences metabolic syndrome furthermore adipokines involved regulation inflammatory processes autoimmunity light pathogenesis connective tissue diseases given evidence influence adipokines metabolic syndrome may link cvds rheumatic diseases review provides overview literature focusing role adipokines rheumatic diseases putting special emphasis potential role leptin resistin adiponectin chemerin visfatin novel adipokines connective tissue diseases
background link rosacea inflammatory bowel disease ibd proposed unknown mechanisms epidemiologic evidence association needs examined methods nationwide cohort study total patients rosacea matched patients without rosacea identified taiwanese national health insurance research database cumulative incidences ibd compared cohorts frailty cox proportional hazard model used subgroup analyses conducted examine risk factors ibd results year cumulative incidences ibd confidence interval rosacea nonrosacea cohorts respectively rosacea adjusted hazard ratio male gender adjusted hazard ratio independently associated ibd adjustment major comorbidities multivariate subgroup analyses revealed consistent results incidence rates ibd decreased increasing antibiotic use patients rosacea without statistical significance limitation information related lifestyle diet alcohol smoking included database conclusion patients rosacea may increased risk ibd
origin destination matrix useful tool traffic transport analysis kind matrices increasing volume complexity due availability new technologies gather new information project present novel way representing origin destination matrices using connection barchart two ordinated maps main goal use connection barchart center interactive visualization providing overview dataset interaction information specific origin destination nodes origin destination matrix shown connection barchart coordinated maps giving user information origin destination direction volume flow additionally evaluation users conducted test usefulness usability interactive visualization using real data rbt system bogota colombia
curiosity tendency engage novel challenging opportunities may important source resilience risk suicide hypothesized curiosity would buffering effect risk conferred multiple sources distress whereby curiosity would associated reduced suicidal ideation increased coping efficacy part larger intervention trial designed improve coping skills reduce suicidal ideation military veterans suicidal ideation completed measures curiosity distress perceived stress depression anxiety sleep disturbances baseline completed measures suicidal ideation coping efficacy stop negative thoughts enlist support friends family baseline week follow growth curve models showed curiosity moderated association distress suicidal ideation baseline curiosity moderated association distress increased coping efficacy stop negative thoughts time findings suggest curiosity may buffer effect heightened levels distress suicidal ideation help facilitate stronger gains coping efficacy time additional work examine role curiosity protective factor veterans suicidal ideation
ustekinumab widely used effective biologic treatment chronic plaque psoriasis prospective studies specifically investigated clinical factors may influence treatment outcomes ustekinumab post hoc analysis aimed identify specific clinical factors may influence treatment outcomes ustekinumab psoriasis patients marcopolo study korean patients moderate severe psoriasis analyzed assess influence baseline characteristics clinical factors clinical response improvement psoriasis area severity index pasi pasi ustekinumab addition differences pasi pasi responses responder group non responders evaluated weeks multiple logistic regression analysis used determine adjusted clinical factors predicting treatment outcomes among patient characteristics week significant difference pasi pasi response based prior biologic experience although difference persist week addition adjusting effects relevant clinical factors biologic experience significantly associated less pasi odds ratio pasi responses week presence comorbidities higher among non responders among pasi pasi responders weeks statistically significant previous biologic use clinical factor predicting less response week although influence clinical response week studies warranted investigate association presence comorbidities clinical response
position information plays pivotal role wireless sensor network wsn applications protocol algorithm design recent years range free localization algorithms drawn much research attention due low cost applicability large scale wsns however application range free localization algorithms restricted dramatic accuracy degradation practical anisotropic wsns mainly caused large error distance estimation distance estimation existing range free algorithms usually relies unified per hop length phl metric nodes phl different nodes might greatly different anisotropic wsns resulting large error distance estimation find although phl different nodes might greatly different exhibits significant locality nearby nodes share similar phl anchors know positions advance based locality phl novel distance estimation approach proposed article theoretical analyses show error distance estimation proposed approach one fourth state art pattern driven scheme pds anchor selection algorithm also devised improve localization accuracy mitigating negative effects anchors poorly distributed geometry combining locality based distance estimation anchor selection range free localization algorithm named selective multilateration proposed simulation results demonstrate achieves localization accuracy higher communication radius nodes compared state art solution improves distance estimation accuracy improves localization accuracy consequently
case measurement noise involves impulsive interference distributed estimation algorithms based mean square error mse criterion may suffer severely degraded convergence performance divergence address problem modify adapt combine atc diffusion lms dlms algorithm applying sign operation error signals agents develop diffusion sign error lms dse lms algorithm furthermore stochastic behavior dse lms algorithm analyzed gaussian inputs contaminated gaussian noise based price theorem simulation results show robustness dse lms algorithm impulsive interference validate theoretical findings elsevier rights reserved
research investigates fundamental desire control affects product acquisition authors propose consumers compensate loss perceived control buying utilitarian products household cleaning agents products association problem solving quality promotes sense control study demonstrates basic effect field setting involving real purchases studies show framing product utilitarian hedonic moderates effect control purchase intentions study shows generalized problem solving tendency mediates effect control eagerness pursue utilitarian consumption given pervasiveness ease using product acquisition means cope psychological threat research important implications theory practice
collision detection refers computational problem finding relative placement configuration two objects essential component many applications computer graphics robotics image guided robotic surgery real time collision detection critical preserving healthy anatomical structures surgical procedure however computational complexity problem usually results algorithms operate low speed paper present fast accurate algorithm collision detection oriented bounding boxes obbs suitable real time implementation proposed sweep prune algorithm perform preliminary filtering reduce number objects need tested classical separating axis test algorithm obb pairs interest preserved obb pairs checked separating axis test algorithm obtain accurate overlapping status accelerate execution sweep prune algorithm tailor made proposed method meanwhile high performance scalable hardware architecture proposed analyzing intrinsic parallelism algorithm implemented fpga platform results show hardware design fpga platform achieve around higher running speed software design cpu platform result proposed algorithm achieve collision frame rate khz fulfill requirement medical surgery scenario robot assisted laparoscopy
paper elaborate application maple calculation influence line plane statically determinate truss accurate calculation axial force plane statically determinate truss symbolic computation maple get influence value axial force plot influence line axial force serviced teaching scientific research engineering practice question bank
although key differences found boys girls prosocial behavior toward peers studies systematically examined gender differences intrinsic perspective taking abilities theory mind tom emotion understanding extrinsic peer environment relate prosocial behavior prospective longitudinal study studied gender differences relations children observed prosocial behavior tom social preference ratings children boys girls used conventional tom tasks years age observed prosocial behavior triadic peer interactions assessed time points controlling gender age verbal ability earlier prosocial behavior tom years found predict prosocial behavior years results also revealed gender differentiated associations years whereby girls prosocial behavior positively associated results discussed terms gender differentiated patterns socialization elsevier inc rights reserved
paper proposes parallel regression formulation reduce computational time variable selection algorithms proposed strategy used several forward algorithms order select uncorrelated variables contribute better predictive capability model demonstration proposed method include use successive projections algorithm spa iterative forward technique minimizes multicollinearity spa traditionally used variable selection context multivariate calibration nevertheless due need calculating inverse matrix insertion new variable model calibration computational performance algorithm may become impractical matrix size increases based limitation paper proposes new strategy called parallel regressions strategy implemented spa avoid matrix inverse calculation original spa order increase computational performance algorithm uses parallel computing platform called compute unified device architecture cuda order exploit graphics processing unit called spa cuda purpose used case study involving large data set spectral variables results obtained spa cuda presented times better performance compared traditional spa implementation additionally compared traditional algorithms demonstrated spa cuda may viable choice obtaining model reduced prediction error value
paper integrated implementation manufacturing engineering subject new engineering degrees university malaga analyzed within european higher education area ehea framework identifying methodology used department engineering manufacturing process problems generated development robustness designed organization system justified methodology successfully overcome negative effects multiple changes made delivery first edition subject additionally methodology developed generating significant level student satisfaction comparison near departments overall university
technology rapidly changing nature service customers service frontline experiences customers relationships service providers based prediction marketplace technology service providing humanoid robots melded numerous service experiences article spotlights technology ability engage customers social level critical advancement technology infusions specifically introduces novel concept automated social presence asp extent technology makes customers feel presence another social entity services literature authors develop typology highlights different combinations automated human social presence organizational frontlines indicates literature gaps thereby emphasizing avenues future research moreover article presents conceptual framework focuses relationship asp several key service customer outcomes mediated social cognition perceptions psychological ownership well three customer related factors moderate relationship asp social cognition psychological ownership customer relationship orientation tendency anthropomorphize technology readiness finally propositions presented catalyst future work enhance understanding technology infusion particularly service robots influences customers frontline experiences future
rationale aims objectivesthe nature relationship bipolar disorder borderline personality disorder intense field debate last two decades current diagnostic classifications approach complex phenomenon using syndromatic definitions based presence absence restricted set signs symptoms demonstrated low specificity one several utilities phenomenological method psychiatry complement clinical panorama helping process identifying potential differences two separated clinical syndromes main objective publication explore one particular clinical difference two conditions experience self continuity time perception methodsthe argument explored paper based previous second person phenomenological accounts sufferers conditions results conclusionswhereas borderline personality disorder patients tend experience present moment referring frequent difficulties drawing experiences past order determine future bipolar disorder patients constantly worried contradictions past experiences latent risk losing control future episodes disease contrast however corroborated future research comparing directly two groups terms continuity self temporal structures
background given well documented undesired impacts hiv aids globally need create statistical inventory research output hiv aids need particularly important country lesotho whose hiv aids prevalence one highest globally research hiv aids sub saharan africa continues trail behind regions especially developed countries lesotho sub saharan country developing country lower research output area longitudinally compared countries study reviewed volume scope general research output hiv aids lesotho assessed coverage national research agenda hiv aids making recourse statistical principles methods bibliometric review studies hiv aids retrieved scopus pubmed databases published within year period conducted focus studies analysed studies cross matched national research agenda accordance bibliometric methodologies results total studies comprising journal articles books conference proceedings retrieved proportion estimation burden infection highest research volume basic preventive measures national planning lowest total studies retrieved matched national research agenda research maternal child health quality care viral load point care devices infant point care diagnosis hardly publications high priority research category agenda conclusion notwithstanding considerable research output hiv aids lesotho insufficient coverage national research agenda research area major research gaps general research output basic preventive measures well national planning also need increase targeted funding hiv aids research appropriately address compelling gaps national needs
electrode performances iro tao pbo anodes investigated electrochemical measurements phenol oxidation cyclic voltammetry polarization electrochemical impedance spectroscopy eis conducted phenol solution indicate oxidation ability pbo anode higher iro tao electrode reduce oxygen evolution thus increase effective current novel parameter gamma associated anode materials proposed quantitatively describe effective current applied main reactions value could achieved eis fitted data components equivalent electrical circuits eec suitability used eec checked consistency exchange current density tafel plots eis data involvement novel parameter gamma organics oxidation universal kinetics thereafter presented predict variations chemical oxygen demand average current efficiency power consumption results regression analysis test show higher agreement experimental model estimation phenol oxidation verifying necessity parameter gamma characterizing effective current anodic reactions rationality kinetics describing organics oxidation different electrodes elsevier ltd rights reserved
series superconducting insert coils ics made different materials tested since jaea naka bore central solenoid model coil fields currents several tens fully representative iter operating conditions focus test presently last series central solenoid insert coil aimed confirming performance properties nbsn conductor manufactured japan used wind iter modules typical large scale applications cooldown ambient supercritical temperature may take long time order several weeks useful also perspective future tests optimize purpose comprehensive model implemented code developed presented paper model validated experimental data actual scenario showing good agreement simulation measurements maximum temperature difference across coil roughly estimated measurements extracted results simulation shown much larger maximum value prescribed basis allowable thermal stress materials optimized scenario finally designed using model initial phase allows reducing needed time similar still satisfying major constraints recommendations also given better location choice thermometers used monitoring maximum temperature difference across coil
note find constructions non splitting bent functions thus solving open problem dobbertin leander technical conditions also construct bent functions level splitting bent functions level elsevier rights reserved
multiwatt power amplifier operating frequency range ghz reported whose output amplitude determined digital input words power dac operation amplifier employs cmos digital control directly connected gan fet operating common gate mode use gan fet allows power supply voltages excess used load resistance ohms directly connected gan fet thereby avoiding bandwidth limitations output matching networks output power range drain efficiencies obtained octave bandwidth
purpose risk factors associated clients major impact successful delivery project early design construction operation stages risk management studies conducted far succeeded providing effective risk assessment methodology clients analysing managing risk factors cause project delays cost overruns purpose paper provide methodology client based risk management model design methodology approach conceptual framework designed integrating findings literature review construction industry survey kingdom saudi arabia framework includes risk identification risk analysis mitigation strategy key components model model framework developed integrating analytical hierarchy process ahp monte carlo simulation mcs underpinned within risk program findings case study used demonstrate proposed methodology results found model helps analyse quantify impact risk factors also assist taking suitable risk mitigation strategy particularly early design stage construction process practical implications model applicable public private clients need know possible project duration new construction project take proactive actions avoid adverse effect client risk factors early stage project originality value model expected help understanding nature analysing influence client risk factors cause project delays cost overruns development methodology managing client based risk construction processes early design stage key value study
paper presents evaluates advance hybrid key management architecture supervisory control data acquisition scada networks hskma supports three types communications unicast multicast broadcast hskma based elliptic curve cryptography symmetric cryptography elliptic curve cryptography used communication master station unit msu sub msus symmetric cryptographic algorithm used communication sub msus slave stations limited computational resources analysis shows hskma following distinctive advantages supports security requirement availability forward security backward security supports required speed modbus implementation suitable environments limited computational resources copyright john wiley sons ltd
although positive effects vaginal estrogens selective estrogen receptor modulator ospemifene vaginal epithelium well recognized less known regarding effects therapies lower urinary tract vaginal muscularis clinical evidence suggests vaginally administered estrogenmay improve overactive bladder related symptoms objective study compare effects vaginal conjugated equine estrogens cee vaginal wall lower urinary tract rat model menopause contractile force bladder neck dome external urethral sphincter optimal field stimulation differ significantly among treatment groups pharmacologic responses atropine carbachol potassium chloride similar among groups vaginal epithelial thickness differentiation differentially regulated cee ospemifene altered epithelial differentiation pathways vaginal epithelium unique way effects additive local cee unless contraindicated beneficial effects vaginal cee vaginal wall outweigh summary sentence although ospemifene effect lower urinary tract alters vaginal epithelium unique way additive local estrogen
systematic review meta analysis observational studies indicated use antipsychotics associated nearly fold increase risk fracture first generation antipsychotics fgas appeared carry higher risk fracture second generation antipsychotics sgas risk fractures associated use antipsychotic medications inconsistent evidence different drug classes systematic review meta analysis conducted evaluate whether association use antipsychotic drugs fractures searches conducted pubmed embase databases identify observational studies reported quantitative estimate association use antipsychotics fractures summary risk derived random effects meta analysis search yielded observational studies participants fracture cases compared nonuse use fgas associated significantly higher risk hip fractures use second generation antipsychotics sgas associated attenuated still significant risk hip fractures risk fractures associated individual classes antipsychotic users heterogeneous odds ratios ranged chlorpromazine associated highest risk risperidone associated lowest risk fracture fga users higher risk hip fracture sga users fgas sgas associated increased risk fractures especially among older population therefore benefit label use antipsychotics elderly patients weighed risks fracture
stochastic resource allocation sra problem extensive class combinatorial optimization problems widely existing complex systems communication networks unmanned systems sra ability resource complete task described certain probability objective maximize reward appropriately assigning available resources different tasks paper aimed important branch sra stochastic sra ssra probability resources complete tasks also uncertain firstly general ssra model multiple independent uncertain parameters gssra miup built formulate problem scenario based reformulation address multi source uncertainties proposed facilitate problem solving process secondly view superiority differential evolution algorithm real valued optimization discrete version algorithm originally proposed combined specialized local search create efficient hybrid optimizer hybrid algorithm compared discrete differential evolution algorithm pure random sampling method well restart local search method experimental results show proposed hybrid optimizer obvious advantages solving gssra miup problems
impairment facial emotion perception believed associated aggression schizophrenia patients antisocial features impaired facial emotion perception counterparts without features however previous studies define comorbidity antisocial personality disorder aspd using stringent criteria recruited participants dual diagnoses aspd schizophrenia participants schizophrenia controls employed facial emotional recognition paradigm measure facial emotion perception administered battery neurocognitive tests life history aggression scale used anovas ancovas conducted examine group differences facial emotion perception control effect neurocognitive dysfunctions facial emotion perception correlational analyses conducted examine association facial emotion perception aggression patients dual diagnoses performed worst facial emotion perception among three groups group differences facial emotion perception remained significant even neurocognitive impairments controlled severity aggression correlated impairment perceiving negative valenced facial emotions patients dual diagnoses findings support presence facial emotion perception impairment association aggression schizophrenia patients comorbid aspd elsevier ireland ltd rights reserved
study involved performance evaluation multistage jatropha fruit shelling machine used produce jatropha kernels oil rich nucleus higher purity removing outer shells fruits husks seeds coating reduction shells husks together commonly practised moment improve oil yield quality oil extraction process biodiesel production shelling machine consists two cracking unit different roller clearance different stage decortications every roller featured male threads surface male threads different rotating directions speeds provoke shearing effect onto loaded jatropha fruits machine design also deploys multistage separation mechanisms consisting vibratory sieve blowers purpose produce cleaner kernels designed machine tested different blower air speeds fruit moisture contents optimal air speed fruit moisture content found around respectively husks could removed without causing high kernel loss overall results show designed machine optimal conditions able remove shells husks controlling kernel loss around separation process applies blower separation mean analysed using eulerian model dense discrete phase model ddpm ansys fluent purpose understand behaviour jatropha fruits particles air flow separation process simulation revealed vortices existed converging portion slope end designed separator duct due instantaneous changes air velocity pressure formation vortices could change flowing direction particles lengthen residence time particles duct phenomena also found able cause momentum loss heavier kernel particles achieving reduction kernel loss separation process simulation results provided basis understand dynamics multiphase flow numerical model makes study possible provide better insight making decision along future developed scaling factor machine scaled activity elsevier rights reserved
despite clinical guidelines national data describing use one contraceptive method best common way prevent unintended pregnancy limited evidence indicates complex picture actual contraceptive practice face face depth interviews conducted november sample women two cities united states interviews explored ways participants used contraception protect unintended pregnancy past months respondents reported using multiple methods many considered less effective within timeframe practice combining methods order increase one level protection pregnancy prevalent mainly enacted two ways backing inconsistent method use methods buttressing methods practices found common complex previously described literature behaviors mainly informed deep anxiety efficacy contraceptive methods respondents perceived ability prevent pregnancy findings challenge prevailing assumptions women contraceptive method use implications clinical contraceptive counseling practice
paper explores issue group integrity tuple subsets regarding corporate integrity constraints relational databases solution may found applying finite state machine theory guarantee group integrity data present practical guide coding automaton creating sql queries manipulate data control integrity real data domains study issue query performance determine level transaction isolation generate query plans
family members caring young person diagnosed onset mental health problems face heightened stress depression social isolation despite evidence effectiveness family based interventions sustaining access specialist family interventions major challenge availability internet provides possibilities expand sustain access evidence based psychoeducation personal support family members paper describe therapeutic model components purpose built moderated online social therapy program families outline background development beginning face face episode family intervention informed selection therapeutic content integration recent developments positive psychology online interventions carers integrate online therapy online social networking peer expert support online social problem solving designed reduce stress carers initial version application entitled meridian shown safe acceptable feasible feasibility study carers youth diagnosed depression anxiety significant reduction self reported levels stress caregivers change stress significantly correlated use system subsequently launched cluster rct caregivers relative diagnosed first episode psychosis intervention potential improve access effective specialist support families facing onset serious mental health problems young relative
nature inspired algorithms cuckoo optimization algorithm coa produces population candidate solutions find near optimal solutions problem paper several modifications including dynamic mutation operator proposed algorithm design experiments employed determine factors controlling value parameters target levels values achieve desirable output efficiency modified coa algorithm substantiated help several optimization test problems results compared well known algorithms pso harmony search using non parametric statistical procedure order analyze effectiveness proposed modified coa applied feature selection problem spacecraft attitude control problem
antifouling polymers wide applications biomedical engineering marine industry recently zwitterionic materials reported promising candidates antifouling applications strong hydration believed key antifouling mechanism zwitterionic materials designed various molecular structures affect hydration antifouling performance although strong hydration proposed occur material surfaces probing solid material water interfaces challenging traditional analytical techniques review review studies surface hydration zwitterionic materials antifouling materials using sum frequency generation sfg vibrational spectroscopy provides molecular understanding water structures various material surfaces materials studied include zwitterionic polymer brushes different molecular structures amphiphilic polymers zwitterionic groups uncharged hydrophilic polymer brushes amphiphilic polypeptoids widely used antifouling material poly ethylene glycol compare differences among zwitterionic materials various molecular structures well differences antifouling materials fouling surfaces control samples also discuss effects biological molecules like proteins surface hydration zwitterionic materials using sfg spectroscopy measured hydration layers antifouling materials found strong hydrogen bonds key formation strong hydration layers preventing protein fouling polymer interfaces statement significance antifouling polymers wide applications biomedical engineering marine industry recently zwitterionic materials reported promising candidates antifouling applications strong hydration believed key antifouling mechanism however zwitterionic materials designed various molecular structures affect hydration antifouling performance moreover although strong hydration proposed occur material surfaces probing solid material water interfaces challenging traditional analytical techniques manuscript review studies surface hydration zwitterionic materials antifouling materials using sum frequency generation sfg vibrational spectroscopy provides molecular understanding water structures various material surfaces materials studied include zwitterionic polymer brushes different molecular structures amphiphilic polymers zwitterionic groups uncharged hydrophilic polymer brushes amphiphilic polypeptoids widely used antifouling material poly ethylene glycol compare differences among zwitterionic materials various molecular structures well differences antifouling materials fouling surfaces control samples also discuss effects biological molecules like proteins surface hydration zwitterionic materials sfg results indicate strongly hydrogen bonded water materials surfaces strong surface hydration closely correlated good antifouling properties materials review widely interested readers acta biomaterialia impact many different research fields chemistry materials engineering beyond acta materialia inc published elsevier ltd rights reserved
introduction mechanisms underlying effects cigarette smoke smoking cessation respiratory secretion especially larynx remain unclear objectives aims study determine effects cigarette smoke smoking cessation laryngeal mucus secretion inflammation investigate effects glucocorticoid administration methods administered cigarette smoke solution css eight week old male sprague dawley rats four weeks examined laryngeal mucus secretion inflammatory cytokine expression days smoking cessation also investigated effects glucocorticoid triamcinolone acetonide administered day smoking cessation results exposure css resulted increase laryngeal mucus secretion excacerbated following smoking cessation change coincided increase expression mrna inflammatory cytokines tumor necrosis factor interleukin well mrna mucac involved mucin production triamcinolone suppressed css induced laryngeal mucus hypersecretion pro inflammatory cytokine production conclusion cigarette smoke associated inflammation may contribute exacerbated laryngeal mucus hypersecretion occurs following smoking cessation inflammatory response represents promising target treatment cigarette smoke associated mucus hypersecretion authors published elsevier ireland ltd open access article ncnd license http creativecommons org licenses
purpose purpose paper determine relationship indoor environmental quality ieq occupants productivity improvements green buildings order propose probable enhancements national green certification criteria design methodology approach survey approach selected quantitative phenomenon hence questionnaire survey selected primary data collection technique linked semi structured interviews validate survey results survey data analysed using nonparametric statistical analysis techniques significance testing spearman correlation statistical package social science spss statistical analysis software used data analysis findings seven factors identified significant factors showed statistically significant monotonic correlation major ieq dimensions among air quality acoustical partitioning factors confirmed statistically significant weak positive monotonic correlation whilst system control showed strongly positive monotonic correlation occupants productivity green buildings practical implications findings practically implied basis review existing evaluation criteria ieq national green certification system propose probable enhancements originality value significant ieq factors influencing occupants productivity determined focal point research accordingly new provisions proposed enhance national green certification criteria
adhesively bonding fiber reinforced polymer frp composites reinforced concrete members simple highly effective method restore strength increase loading capacities extend service life structures growing demand wider applications strengthening systems durability recently received significant attention research community largely form laboratory testing deteriorated frp concrete joints develop generalized deterioration factors database shear tests collected quantitatively assess change bond characteristics across number environmental conditions identified major shortcoming existing test data reporting full range load displacement behavior limited supplement existing data experimental study devised assess deterioration carbon frp bonded systems three aqueous conditions investigation consists continually immersing specimens water salt solution first time sulfuric acid solution simulate pooling acid rain results show sulfuric acid attack detrimental durability bond using mechanics based numerical model bond properties extracted present results well published literature determine conservative deterioration factors change bond characteristics environmental exposure american society civil engineers
background hip fractures cause increased mortality disability consume enormous healthcare resources hip fracture patients osteoporosis total hip according dual energy ray absorptiometry dxa measurement cortical porosity increases ageing believed important bone strength objective investigate whether older women hip fracture higher cortical porosity controls whether difference independent clinical risk factors areal bone mineral density abmd methods ongoing population based study identified women prevalent rayverified hip fracture control subjects without fractures abmd measured dxa high resolution peripheral quantitative computed tomography used measure bone microstructure standard ultradistal site distal tibial length results women previous hip fracture lower abmd femoral neck total hip well higher cortical porosity ultradistal distal tibia compared controls multivariable logistic regression analysis adjustment covariates age height weight smoking calcium intake physical activity walk time oral glucocorticoids parental hip fracture rheumatoid arthritis previous fall current bisphosphonate treatment femoral neck abmd cortical porosity ultradistal odds ratio per standard deviation increase confidence interval distal sites associated prevalent hip fracture conclusion cortical porosity associated prevalent hip fracture older women independently femoral neck abmd clinical risk factors
recently developed slantlet transform slt short wavelet two zero moments achieve better balance time domain localization smoothness due excellent characteristics slt expected widely used information science fields compression denoising various signals however slt without place algorithm suitable parallel implementation matrix formation algorithm design slt lack universality either address issues present new method generating slt recursively perspective matrix rather wavelet utilizing basic techniques bisection evolution including called haar copy walsh mutation slant mutation slantlet mutation techniques meanwhile obtain new orthogonal transform named slantlet walsh slw short transform design place fast algorithms slt slw transforms symmetry structure suitable parallel computing addition proposed scheme clear easy extended may take copy means select mutation parameter value generate new orthogonal matrices required properties may special application value fields validated experiment proposed slt well suited deal piecewise linear signal comparison transforms haar walsh slant slant haar slw transforms dct elsevier inc rights reserved
objectiveto investigate baseline shape weight concern swc moderated outcomes prevention across spectrum randomized controlled trial rct school based programs aimed reducing eating disorder obesity risk factors methodn grade girls boys age years across three australian states randomly allocated media smart life smart helping encouraging listening protecting peers initiative helpp control usual school class moderation explored testing interaction effects group media smart life smart helpp control moderator swc higher swc lower swc time post program month follow month follow baseline risk factor scores entered covariates resultsmoderation effects found shape concern weight concern eating concern regular eating meal skipping physical activity body dissatisfaction dieting perfectionism post hoc testing found eating concern post program variable higher swc media smart participants experienced reduction risk relative controls higher swc life smart helpp participants reported increase eating concern relative controls groups skipping meals controls month follow amongst lower swc participants media smart group experience benefit relative controls physical activity conclusionsthis study highlights need moderator analyses become routinely conducted universal trials ensure participants across baseline risk levels benefiting harmed program participation wiley periodicals inc int eat disord
atrial fibrillation cavotricuspid isthmus cti dependent atrial flutter afl two separate entities coexist significant percentage patients sought investigate whether inducibility cti afl ablation predicted occurrence follow successful afl ablation systemic review medline cochrane embase done clinical studies assessment inducibility patients undergoing ablation cti afl performed given low heterogeneity used fixed effect model analysis total studies prospective retrospective total patients male mean age years fulfilled inclusion criteria mean follow period months patients developed afl ablation overall incidence new onset follow group inducible non inducible group odds ratio developing afl ablation patients inducibility studies combined prospective studies retrospective studies although ablation cti afl highly effective continues long term risk individuals undergoing procedure induced pacing protocols patients undergoing cti afl predicts future inducible clinically relevant finding may help guide decisions long term anticoagulation successful typical afl ablation especially patients elevated chads vasc scores considering prophylactic pvi cti afl ablation
ankylosing spondylitis patients cardiac vascular involvement may manifest atherosclerosis coronary artery disease systemic inflammation oxidative stress increased low density lipoprotein ldl cholesterol decreased high density lipoprotein hdl cholesterol constitute significant risk atherosclerosis study investigated relationship carotid intima media thickness cimt ldl hdl ratio total oxidant status tos indicator oxidative stress ischemic modified albumin ima ischemic marker patients sixty patients diagnosed using modified new york criteria age gender matched participants included controls cimt ldl hdl ratio tos ima measured using appropriate methods ima higher patients compared controls tos also increased patients cimt ldl hdl ratio also greater patients compared controls positive correlation found cimt ldl hdl ratio among patients elevated cimt ima tos levels suggest increased risk atherosclerotic heart disease patients ldl hdl ratio higher patients compared controls correlation ldl hdl ratio cimt albeit statistically weak therefore ldl hdl ratio reliable marker predict atherosclerotic heart disease patients
article include arabic numbers photographs number special symbol scanning character image object identification key technology card number character recognition research analyzes various factors influence efficiency identification effectiveness various modules process character recognition algorithm key research elaborate detail finally complete character recognition system based improving algorithm design implementation testing main tasks include following first detailed several image binarization processing methods compare treatment effect uneven distribution target area background area difficult isolate problem proposed implemented improvements based local iterative otsu algorithm verify validity experiment second brief introduction feature extraction methods character recognition back propagation neural network research application wide range error overall adaptive momentum term learning rate network slow network convergence easy fall local minimum defects improvements improved classifier experimental verification superiority third complete entire character recognition system design implementation testing actual test results show proposed algorithm design system feasible effective entire system algorithm able meet requirements quick identification
academics higher education institutions often experience conflicting demands teaching research administration growth online education staff frequently required design develop teach facilitate cases administer online courses cumulatively additional tasks challenge academics terms personal professional development also accommodating range tasks expected paper reports findings study investigated lived experience construction management academics teaching universities australia study adopted lived experience research approach enabled lives construction management academics investigated collection mixture qualitative quantitative data study provides empirical evidence range challenges facing delivering online courses recommendations online teachers online course designers emerged study application faculty based institution wide practices findings relevant higher education sector involved online teaching course design online delivery professional development related online initiatives
neuroscience investigations emotional influences social cognition dominated somatic marker hypothesis dual process theories taken together lines inquiry provided strong evidence emotional influences social cognition rely neural systems code bodily signals arousal distinguish emotional reasoning modes reasoning recent findings raise possibility emotionally influenced social cognition relies two stages neural changes emotion elicited different set changes time social cognitive judgment findings suggest affect infusion models may fruitful framework bridging neuroscience psychological understanding role emotion social cognition
background explored knowledge attitudes regarding copper intrauterine device iud emergency contraception among women buenos aires argentina study design interviewed convenience sample women attending family planning center public hospital participants asked knowledge use contraceptives including pre script given information iud subsequently asked acceptability using copper iud post script primary outcome analysis results analyzed data women participants knew iud served baseline said would willing use device need arose given relevant information multivariate results pre script revealed women low levels education born outside argentina less knowledgeable pills previous use iud associated high levels iud knowledge post script results indicated argentine odds ratio confidence interval previous iud use positively associated considering iud nulliparity negatively associated willingness use iud conclusion examined acceptability copper iud latin american setting found prior levels knowledg low acceptability iud high implications programming policy include outreach education regarding highly effective method advocacy change existing regulations argentina prohibiting use iud implications given information iud method women interviewed said would willing use iud despite limited prior knowledge method widespread information availability iud women may opt highly effective method provide additional protection unwanted pregnancy years elsevier inc rights reserved
objective study aimed quantify cartilage subchondral bone related effects low dose high dose meloxicam treatment late phase mono iodoacetate induced osteoarthritis stifle methods thirty four male wistar rats received intra articular injection mono iodoacetate trigger osteoarthritis control animals grp received saline mono iodoacetate injected rats assigned three groups treated week end week placebo grp low dose grpm high dose grpm meloxicam period additional weeks end week animals sacrificed stifle joints examined histologically immunohistochemically cyclooxygenase conformity recommendations osteoarthritis research society international serum cytokines tnf alpha measured end weeks results compared saline treated controls animals treated mono iodoacetate developed various degrees osteoarthritis cartilage degerieration score total cartilage degeneration width significantly lower low dose high dose rneloxicam treated groups placebo group subchondral bone high dose rneloxicam exerted significant protective effect low grade cox expression observed placebo treated animals abolished meloxicam groups increase borderline significance tnf alpha grpp week week reduction grpm week week observed conclusion rat model osteoarthritis low dose high dose meloxicam chondroprotective effect high dose also protected subchondral bone lesions results suggest superior protection high dose meloxicam arresting low grade inflammatory pathway accompanied chronic cartilage deterioration
purpose purpose paper provide overview human resource development hrd education middle eastern countries particular authors discuss current state hrd education country readiness challenges hinder hrd progress middle eastern countries argue hrd programs need prepare young employees leadership roles adapting constructivist pedagogy including problem solving critical thinking creativity design methodology approach design paper followed qualitative approach authors conducted depth interviews five hrd experts middle eastern countries conducted integrative literature review secondary data analysis findings data analysis provided overview hrd education looked options individuals interested hrd education might provided views constructivism instructivism education pedagogies discussed cultural factors impede critical reflection workplace research limitations implications understand introduce constructivist elements instructivist learning cultures sustain hrd scholars middle eastern countries need diminish misalignment instructional philosophies trainers trainees national institutional systems practical implications understanding policy resources infrastructure culture influence learning expectations vital introducing innovative training activities scaling workshops systems originality value research sheds light hrd education middle eastern countries provides overview employment challenges opportunities improve workplace learning provides scholars practitioners stakeholders interested hrd suggestions develop successful workforce education
novel approaches studying brain relating activities mental phenomena come use past decade bargmann include new laboratory methods involving among others generation isolated cells retain neuronal characteristics vivo selective stimulation neurons light vivo direct electrical stimulation specific brain regions restore system balance excitation inhibition new organizing principle connectomics recognizes networks simply key nucleus region underlie brain functions malfunctions application already improved comprehension brain normally functions ability help patients poorly treated neurologic psychiatric diseases alzheimer disease elsevier inc rights reserved
aims study aims investigate resting state functional connectivity right frontoparietal network rfpn migraineurs healthy controls hcs order determine rfpn modulated effective treatment methods one hundred patients matched hcs recruited migraineurs randomized verum acupuncture sham acupuncture waiting list groups resting state functional magnetic resonance imaging data collected longitudinal treatments independent component analysis applied data analysis results found migraineurs showed decreased rfpn bilateral precuneus compared hcs treatments real sham rfpn precuneus significantly reduced reduction associated headache intensity relief order explore role precuneus acupuncture modulation performed seed based analysis using precuneus seed found precuneus bilateral rostral anterior cingulate cortex medial prefrontal cortex ventral striatum dorsolateral prefrontal cortex significantly enhanced treatment conclusion results suggest migraineurs associated abnormal rfpn effective treatment acupuncture may relieve symptoms strengthening cognitive adaptation coping process elucidation adaptation coping mechanisms may open new window migraine management
tumor necrosis factor alpha tnf induced osteoclastogenesis profound effects states inflammatory osteolysis rheumatoid arthritis periprosthetic implant loosening periodontitis however exact mechanisms tnf alpha promotes rankl induced osteoclast formation remains poorly understood lymphocyte induced maturation protein blimp transcriptional repressor plays crucial roles differentiation function various kinds cells including osteoclasts novel mechanism identified tnf alpha mediated blimp expression contributed rankl induced osteoclastogenesis shown tnf alpha could promote level blimp expression osteoclast differentiation silencing blimp osteoclast precursor cells obviously attenuated stimulatory effect tnf alpha osteoclastogenesis mechanistically tnf alpha induced blimp expression markedly rescued blocking pik akt signaling pathway suggested pik akt signaling involved regulation tnf alpha stimulated blimp expression taken together results established molecular mechanism tnf induced osteoclasts differentiation provided insights potential contribution blimp regulation osteoclastogenesis tnf alpha cell biochem wiley periodicals inc
advances nanotechnology enabled production characterization magnetic nano particles nanometer sized features functionalized material sciences bio engineering materials engineering etc iron oxides iron oxide compounds importance fields including biomedicine clinical bio sensing applications corrosion resistance lubrication magnetic properties materials catalyst geochemical processes etc magnetic nano sized iron oxide particles synthesized precipitation method fecl center dot fecl center dot dissolved deionized water vigorous stirring added organic components solution preventing agglomeration particles synthesizing magnetite nanoparticles obtained two ways first adding glycerin solution second continue stirring throughout slow addition fine powder sodium oleate shows ferro fluid additional glycerin component contained heterogeneous agglomerations iron oxide particles bubbled structure solution added sodium oleate components uniform distribution nanoparticles liquid solution
guideline occupational allergic diseases published first time japan occupational allergic diseases likely worsen become intractable result continuous exposure high concentrations causative antigens socioeconomically important diseases patients might sometimes lose jobs due work interruptions guidelines occupational allergic diseases published many countries guideline consists six chapters occupational asthma occupational allergic rhinitis occupational skin diseases hypersensitivity pneumonitis occupational anaphylaxis shock legal aspects diseases guideline characterized following basic structure clinical questions cqs set reference minds medical information network distribution service statements committee correspondingly listed recommended grades evidence levels defined descriptions references indicated copyright japanese society allergology production hosting elsevier
presentation review recent work realization application two fundamental optical analog signal processing functionalities namely photonic temporal differentiation photonic temporal integration using customized grating devices directly written optical fibers
photovoltaic energy conversion becomes main focus many researches due promising potential source future electricity many advantages alternative energy sources like wind solar ocean biomass geothermal etc photovoltaic power generation multilevel inverters play vital role power conversion three different topologies diode clamped neutral point clamped inverter capacitor clamped flying capacitor inverter cascaded bridge multilevel inverter widely used multilevel inverters among three topologies cascaded bridge multilevel inverter suitable photovoltaic applications since array act separate source bridge module paper presents single phase cascaded bridge five level inverter grid connected photovoltaic application using sinusoidal pulse width modulation technique inverter output voltage waveform reduces harmonics generated current filtering effort input control strategy allows independent control link voltages tracks maximum power point strings topology inject grid sinusoidal input currents unity power factor achieves low harmonic distortion pid control algorithm implemented arm processor lpc validity proposed inverter verified simulation implemented single phase prototype results hardware compared simulation results proposed system offers improved performance conventional three level inverter terms thd
backgroundmany patients cirrhosis follow complex medication dietary regimens decompensated cirrhosis suffer debilitating complications factors impact activities daily living quality life aimsto explore concerns challenges people cirrhosis use support services also describe health professionals perspectives patients concerns methodsthis cross sectional study tertiary liver clinic involving patients data collected using structured questionnaires study includes patients report challenges problems cirrhosis patient volunteered concerns report patients concerns also ranked list potential concerns resultspatients average years old mostly male caucasian compensated cirrhosis patients common volunteered concerns related managing symptoms emotional issues disease ranked developing liver cancer losing ability daily tasks fear dying fear unknown priority concerns regarding use support services patients accessed dietician pharmacist psychologist perspective patients significant challenges related managing disease symptoms access healthcare information knowledge conclusionsour findings demonstrate cirrhosis symptoms complications treatment associated significant concerns patients discrepancies views patients suggest may measuring addressing patients needs appropriately
introduction electronic cigarettes cigarette designed look like traditional cigarettes simulate visual sensory behavioral aspects smoking traditional cigarettes research aimed explore whether different cigarette models smokers usual classic cigarettes impact cognitive performances craving gesture methods study randomized cross trial designed compare cognitive performances craving gesture subjects used first generation electronic cigarettes second generation electronic cigarettes usual cigarettes trial registration clinicaltrials gov number nct results cognitive performance affected group condition within group repeated measures analyses showed significant time effect indicating increase participants current craving measure group usual classic cigarettes group disposable cigalike electronic cigarette loaded cartridges nicotine group second generation electronic cigarette personal vaporizer model ego loaded liquid nicotine group measures gesture differ course experiment products investigation conclusion cognitive measures attention executive function working memory influenced different cigarette gender showing general electronics cigarettes could become strong support also cognitive point view decide quit smoking seems craving smoke withdrawal symptoms also cognitive performance linked presence nicotine suggests reasons behind dependence related difficulty quit smoking needs looked also factors like gesture
turbochargers increasingly important module modern vehicles calibration turbocharger unit requires measurement performance parameters namely pressure ratio mass flow efficiency function rotational speed hot gas stand built provide test bench facility university malta mechanical design briefly outlined paper emphasis data acquisition control details specifically designed electronic circuits labview arc main focus paper measurement shaft speed non contact hall effect sensor described circuitry designed extract small signal measurement detailed level noise significant mostly due inverter used power motor required drive supercharger pushed air combustion chamber temperature control exhaust gases going combustion chamber controlled pid controller labview regulated fuel quantity admitted combustion chamber fuel used liquefied petroleum gas vapor state fuel metering achieved pulse width modulation metering valve small buffer tank utilized downstream pulse width modulated valve stabilize pressure downstream valve supplied burner
nonessential amino acids synthesized novo therefore diet dependent contrast essential amino acids must obtained nutrition since synthesized internally several nonessential amino acids may become essential conditions stress catabolic states capacity endogenous amino acid synthesis exceeded arginine glutamine conditionally essential amino acids focus review low arginine bioavailability plays pivotal role pathogenesis growing number varied diseases including sickle cell disease thalassemia malaria acute asthma cystic fibrosis pulmonary hypertension cardiovascular disease certain cancers trauma among others catabolism arginine arginase enzymes common cause acquired arginine deficiency syndrome frequently contributing endothelial dysfunction cell dysfunction depending clinical scenario disease state glutamine arginine precursor one abundant amino acids body like arginine becomes deficient several conditions stress including critical illness trauma infection cancer gastrointestinal disorders risk populations discussed together therapeutic options target specific acquired amino acid deficiencies
social rhythms also known daily routines exercise school work recreation social activities identified potential time cues help regulate biological clock past research shown links regularity healthy sleep study examined regularity frequency daytime activities clinical insomnia population good sleeper comparison group participants prospectively monitored sleep daily activities week period although participants insomnia good sleepers similar levels activity relative good sleepers insomnia less regular activities findings study add growing number studies highlight relative importance regularity daytime activities sleep accordingly future research test treatment components focus regulating daytime activities would likely improve treatment outcomes
backgroundcontinuous positive airway pressure cpap asthma patients concomitant obstructive sleep apnea syndrome osas seems favorable impact asthma data inconsistent due methodological limitations previous studies methodsprospective multicenter study examined asthma outcomes months cpap adult asthma patients mean age years osas respiratory disturbance index asthma control quality life assessed asthma control questionnaire acq mini asthma quality life questionnaire miniaqlq respectively data analyzed intention treat basis resultsthe mean score acq decreased baseline months percentage patients uncontrolled asthma percentage patients asthma attacks months treatment score maqlq increased also significant improvements symptoms gastroesophageal reflux rhinitis bronchial reversibility exhaled nitric oxide values significant changes observed drug therapy asthma comorbidities patients weight conclusionsasthma control actual future risk quality life lung function improved starting continuous positive airway pressure asthmatics moderate severe obstructive sleep apnea syndrome
drawing discursive psychology article examines understandings teachers principals danish public schools regarding somali diaspora parenting practices furthermore article investigates understandings mean interaction children classrooms parents home school communication argued society increased focus parental responsibility teachers principals draw deficit logic dealing somali diaspora parents children consequently leads teachers either transmitting expertise educating parents compensating perceived deficiencies parental practices strategies result significant marginalizing consequences difference understood wrong inadequate
developing natural language query interface relational databases gained much interest research community since forty years termed structured free query interface allows users retrieve data database without knowing underlying schema structured free query interface address majorly two problems querying system natural language interfaces nlis comfortable naive users difficult machine understand problem users query system different expressions retrieve information different words used query meaning also word multiple meanings hence responsibility nli understand exact meaning word particular context paper generic nli database system proposed contains various phases exact meaning word used query particular context obtained using ontology constructed customer database proposed system evaluated using customer database precision recall measure authors published elsevier open acess article license
paper design approach sensorless controlled brushless interior permanent magnet machine attained initial study based established electrical machine formulas provides machine basic geometrical sizing next design stage combines particle swarm optimisation pso search routine magneto static finite element solver provide depth optimisation optimisation system formulated derive alternative machine design variants subject design constraints computationally efficient manner using simulations required moreover parallel computing approach used computationally intensive processes optimisation system objective function aims find solution satisfying machine design requirements including torque speed envelope compatibility high frequency injection based sensorless operation whilst minimising machine weight holistic approach presented complete machine including stator rotor sub assemblies designed accounting required performance measures high frequency injection based sensorless operation efficacy new approach demonstrated design case study consecutive design stages discussed detail also paper provides conceptual information regarding practical implementation proposed optimisation system together insight definition objective function influence design solutions furthermore calculated results optimisation system compared direct predictions design exemplar showing good correlation
alzheimer disease microtubule associated protein tau forms intracellular neurofibrillary tangles nfts critical step formation nfts conversion soluble tau insoluble filaments accordingly current therapeutic strategy clinical trials aimed preventing tau aggregation assessed altenusin bioactive polyphenolic compound potential inhibit tau aggregation altenusin inhibits aggregation tau protein paired helical filaments vitro associated stabilization tau dimers oligomers globular structures revealed atomic force microscopy moreover altenusin reduced tau phosphorylation cells expressing pathogenic tau prevented neuritic tau pathology induced incubation primary neurons tau fibrils however treatment tau transgenic mice improve neuropathology functional deficits taken together altenusin prevents tau fibrillization vitro induced tau pathology neurons
frontotemporal lobar degeneration neuropathological disorder causes variety clinical syndromes including frontotemporal dementia ftd progressive supranuclear palsy corticobasal syndrome cbs ftd associated parkinsonism occurs frequently result mutations corf gene also genes coding protein associated microtubule tau mapt progranulin grn chromosome ftdp herein report argentinean family basque ancestry extensive family history behavioral variant ftd twenty one members generations composed pedigree extensive neurologic neurocognitive examination performed symptomatic individuals non symptomatic individuals two different phenotypes identified among affected members cbs proband ftd brother dna extracted blood individuals whole exome sequencing performed followed sanger sequencing candidate genes affected individuals missense mutation exon mapt gene chrq identified among mapt mutations frequently associated different phenotypes aggressive symmetrical andearly onset parkinsonism late parkinsonism associated ftd progressive supranuclear palsy exceptionally reported associated cbs first report occurrence mapt mutation south america supports marked phenotypic heterogeneity among members family previously reported published elsevier inc
masculine self concept refers man psychological sense male study used semantic misattribution procedure assess men implicit masculine self concept expected implicit masculine self concept associated social desirability positively associated several gender relevant outcomes including conformity masculine norms endorsement traditional masculinity ideology hostile sexism benevolent sexism also found support mediation model explicit masculine self concept mediated impact implicit masculine self concept outcomes results provide evidence importance implicit masculine self concept exploring gender relevant outcomes elsevier ltd rights reserved
performance enhanced free spectral range fsr triple ring resonator tmr architecture presented using delay line signal processing technique signal flow graph group delay dispersion presented tmr mathematical model tmr developed domain enhanced fsr suppression crosstalk prime objective larger ring perimeters
tested effectiveness preventive behavioral parent training bpt program incredible years independent effects previously suggested socio demographic intervention based moderator variables initial severity externalizing problem behavior child gender social economic status family composition number sessions parents attended large scale randomized controlled trial questionnaire observation data parents children ages years age boys across pretest posttest month follow analyzed using full intention treat analyses correcting multiple testing successful decreasing parent reported child externalizing behavior cohen posttest follow increasing parent reported observed positive parenting behavior decreasing parent reported negative parenting behavior intervention effects found reported observed child prosocial behavior observed child externalizing behavior observed negative parenting behavior tested moderation effects outcomes moderators three significant moderation effects appeared thus systematic evidence emerged moderation effects present multi informant trial demonstrated many previously suggested moderators might potent differentiating bpt effects thought
despite improved quality care rheumatoid arthritis patients many still experience treatment failure biologic agent eventually switch another biologic agent investigated patterns biologic treatment reasons switching biologics patients patients started biologic agent switched another biologic agent identified prospective observational korean nationwide biologics kobio registry kobio registry contained patients time initiation switching biologic agents patients categorized according chronological order introduction biologic agents reasons switching biologics also evaluated patients started first biologic agent first time switchers second time switchers second time switchers lower rheumatoid factor anti ccp positivity higher disease activity scores time enrollment groups among patients tocilizumab commonly prescribed biologic agent followed adalimumab etanercept common reason switching biologics inefficacy followed adverse events including infusion reactions infections skin eruptions furthermore proportion inefficacy reason switching significantly higher respect switching biologics different mechanisms action biologics similar mechanisms registry showed diverse prescribing patterns differing baseline profiles based chronological order biologic agents
year old man presented month history gradually worsening cough month history dyspnea exertion high resolution computed tomography showed bilateral uniform ground grass opacity lower lung fields partially resolved smoking cessation tentative diagnosis desquamative interstitial pneumonia dip made video assisted thoracic surgery performed pathological analysis showed peribronchiolar fibrosis intra alveolar macrophage infiltration elemental analysis detected aluminum iron upper lobe iron lower lobe thus definitive diagnosis mixed dust pneumoconiosis dip like reaction made dip like reaction known reactive change caused exposure tobacco smoke well inhalation inorganic particles obtaining detailed medical history including occupational environmental risk factors important distinguish cases dip like reaction due exposure inorganic particles usual cases related smoking thus provide suitable treatment jichi medical university published elsevier ltd open access article license
paper presents development intelligent temperature frequency converter measure temperature using negative temperature coefficient ntc thermistor signal conditioning circuit scc ntc thermistor modified timer circuit whose control voltage generated difference amplifier thermistor scc acts temperature frequency converter exhibits moderate linear temperature frequency characteristic range degrees linearity error multilayer perceptron mlp neural network levenberg marquardt algorithm used modeling nonlinearity estimation converter algorithm effectively reduces linearity error compared broyden fletcher goldfarb shanno bfgs scaled conjugate gradient scg algorithms mean square error mse regression coefficients linearity accuracy dispersion spread used evaluate performance proposed ann based modeling intelligence ann based modeling embedded low cost microcontroller unit performance experimentally verified prototype unit linearity error sensitivity proposed unit approximately khz degrees respectively elsevier ltd rights reserved
executive dysfunction deficiency skills planning problem solving characterizes many neuropsychiatric disorders towers task commonly used measure planning problem solving assessing executive function towers task data usually zero inflated right censored ignoring features result biased inference disease characterization executive dysfunction manuscript mixed effects model longitudinal censored semicontinuous data developed analyzing longitudinal towers task data predict study model contrasted current practice implications general use discussed
fixed placements inertial sensors utilized previous human activity recognition algorithms train classifier however distribution sensor data seriously affected sensor placement performance degraded model trained one placement used others order tackle problem fast robust human activity recognition model called transm rkelm transfer learning mixed reduced kernel extreme learning machine proposed paper uses kernel fusion method reduce influence choice kernel function reduced kernel utilized reduce computational cost realizing initial activity recognition model mixed reduced kernel extreme learning model rkelm online phase rkelm utilized classify activity adapt model new locations based high confident recognition results real time experimental results show proposed model adapt classifier new sensor locations quickly obtain good recognition performance elsevier rights reserved
aim research design rainwater filtration system using activated carbon activated carbon act one filter medium filtrate water three filters design namely filter filter filter determine effective filter used study determine effectiveness filter seven parameters measured temperature colour turbidity total suspended solid tss conductivity biochemical oxygen demand bod results shows removal bod tss removal turbidity removal
paper presents design high performance pole slot interior permanent magnet synchronous machine flux barriers inside stator iron core fractional slot concentrated windings work focuses electromagnetic mechanical thermal aspects machine design specific goal work design electrical machine small size high power weight ratio high efficiency especially part load operating points high speed capability traction drive applications therefore unconventional stator design used proposed machine design compared conventional one concerning magnetic saturation spectrum magneto motive force produced torque ensure high speed capability motor numerical structural analysis rotor shown temperature behavior inside designed motor steady state operating point shown
objectives assess health related quality life hrqol anxiety depression gilles tourette syndrome gts adolescents parents compared controls assess gts adolescents hrqol compared controls investigate parental adolescent variables associated poorer parental hrqol controlled study involved gts outpatients parents adolescent healthy controls matched gender age parents parents hrqol assessed using whoqol bref anxiety depression using hads adolescents hrqol assessed adolescents using vsp instrument parents using vsp total gts adolescents mothers fathers compared control adolescents mothers fathers gts mothers worse hrqol controls dimensions whoqol bref dimensions gts fathers worse hrqol whoqol bref dimensions gts mothers poorer hrqol fathers gts mothers depression control mothers gts fathers anxiety control fathers gts adolescents worse hrqol controls vsp dimensions factors significantly related parental hrqol anxiety depression gts adolescents hrqol concerning mothers behavioural emotional adolescents problems concerning fathers severity vocal tics duration since first symptoms study provides better understanding poorer hrqol psychiatric morbidity gts adolescents parents clinicians pay attention emotional well hrqol aware mothers fathers differently affected
large scale atmospheric removal greenhouse gases ghgs including methane nitrous oxide ozone depleting halocarbons could reduce global warming quickly atmospheric removal photo catalysis methane oxidizes effectively reducing global warming potential gwp least nitrous oxide reduced nitrogen oxygen photocatalysis meanwhile halocarbons mineralized red photocatalytic reactions acid halides photocatalysis avoids need capture sequestration atmospheric components review unusual hybrid device combining photocatalysis carbon free electricity intermittency based solar updraft chimney review experimental evidence regarding photocatalytic transformations non ghgs propose combine photocatalysis solar chimney power plants scpps cleanse atmosphere non ghgs worldwide installation scpps capacity would generate cumulative pwh renewable electricity taking account construction time scpps equipped photocatalyst would process atmospheric volume years reducing stopping atmospheric growth rate non ghgs progressively reducing atmospheric concentrations removal methane compared ghgs enhanced efficacy reducing radiative forcing liberates radicals accelerate cleaning troposphere overall reduction non ghg concentration would help limit global temperature rise physically linking greenhouse gas removal renewable electricity generation hybrid concept would avoid moral hazard associated climate engineering proposals authors published elsevier ltd
background severe aphasia chronic condition big effect people severe aphasia pwsa succeed communication communication partner support person aphasia shown essential achieving successful communication however interventions combining training partner pwsa use hierarchical strategies nonverbal communication still needed aims aim present paper describe new intervention appute person aphasia partner receive therapy equally practise finding functional communication strategies convey everyday messages complicated ones data collection appute intervention also presented methods procedures data collected development project including evaluation period two rehabilitation periods follow measurement thirty four pwsa partners participated linguistic functions communication efficiency pwsa evaluated three times rehabilitation communication skills partner also assessed along success mutual communication outcomes results communication skills communication efficiency pwsa partners improved significantly rehabilitation period acquired skills retained months intervention linguistic skills pwsa also improved advanced age partner explained variance partner communication skills success mutual communication amount earlier outpatient speech therapy explained variance communication efficiency pwsa evaluated partners regarding success mutual communication couples able communicate least simple issues end rehabilitation period demanding tasks difficult became succeed especially older pwsa severe motor paralysis people aphasia partners mainly experienced benefits appute intervention part benefits retained follow conclusions appute method appears improve communication skills pwsa partners well linguistic skills pwsa
proposed previous works business process execution language data driven workflow modeling verification execution proposed model present control flow shared data workflow processes analyzed verify correctness deployment paper going improve semantics approach allow better integration data control flow workflow external environment relational databases xml documents also going extend approach generate multidimensional data models namely olap hypercubes data handled workflow order provide synthetic view data decision makers
background fungal nervous system infection difficult diagnosis make due fact specific manifestations disease laboratory confirmation difficult confirm case report report young male presented emergency department variety unilateral visual field complaints initially denied recent drug abuse physical examination highly suggestive fungal infection known result brown heroin use ultimately diagnosed meningitis ventriculitis endogenous endophthalmitis believed result candida species response treatment vitrectomy broad spectrum antimicrobials gave support presumed diagnosis emergency physician aware provide rarely described report possible complication use brown heroin led central nervous system infection involving vision loss fungal infection elsevier inc rights reserved
background focusing upon formal sex education programmes mozambican government significantly enhanced general health adolescents young adults however comes contraception little known adolescents young adults actually behave methods based upon qualitative study two settings maputo province ndlavela boane paper explores knowledge practices contraception among adolescents young adults total four focus group discussions depth interviews four informal conversations observations equally divided study sites results discrepancies adolescents young adults know quickly became evident ambivalent contradictory practices concerning contraceptive use result well young people numerous interpretations risk taking using contraceptives inconsistencies influenced social medical barriers restricted dialogue sexuality among adolescents young adults parents peers additionally ideas indigenous contraceptives notions masculinity femininity misconceptions fear side effects contraceptives make people ages wary modern birth control barriers include imposed contraceptive choice meaning choice overly technical medical language used clinics absence healthcare workers attuned needs adolescents young adults conclusions adolescents young adults numerous often erroneous opinions contraception leading inconsistent use well vague perceptions risk taking moreover social norms cultural gender roles often contradict hinder risk avoiding behaviour therefore order improve young people health policymakers must address reasons behind ambivalence inconsistency
present study examined two measures sympathetic nervous system sns activity moderators indirect path permissive parenting deviant peer affiliations delinquency among community sample adolescents participants included adolescents years boys european american african american multi method design employed address research questions two indicators sns reactivity skin conductance level reactivity sclr cardiac pre ejection period reactivity pepr examined sns activity measured baseline period problem solving task star tracing reactivity computed difference task baseline periods adolescents reported permissive parenting deviant peer affiliations externalizing behaviors substance use alcohol marijuana analyses revealed indirect effects permissive parenting delinquency via affiliation deviant peers additionally links permissive parenting affiliation deviant peers affiliation deviant peers delinquency moderated sns reactivity less sns reactivity less pepr less sclr risk factors externalizing problems alcohol use findings highlight moderating role sns reactivity parenting peer pathways may contribute adolescent delinquency point possibilities targeted interventions vulnerable youth
salix psammophila caragana korshinskii two common shrubs southern desert china hydraulic strategies adapting harsh dry desert environment yet clear study examined hydraulic transport efficiency vulnerability cavitation daily embolism refilling leaves stems two shrubs dry season order gain insight water use strategies whole plants related traits also considered including daily changes stomatal conductance leaf mass per area leaf pressure volume parameters wood density huber value leaves stems psammophila greater hydraulic efficiency vulnerable drought induced hydraulic dysfunction korshinskii difference leaf stem water potential loss conductivity mpa psammophila mpa korshinskii midday stomatal conductance decreased compared psammophila whereas change occurred korshinskii daily embolism refilling occurred stems psammophila leaves korshinskii results suggest stricter stomatal regulation daily embolism repair stems higher stem water capacitance could partially compensating greater susceptibility xylem embolism psammophila whereas higher leaf elastic modulus greater embolism resistance stems larger difference leaf stem hydraulic safety drought induced leaf shedding korshinskii largely responsible extensive distribution arid desert steppes
smart acidochromic agarose based film bis para hydroxystyryl benzene responsive fluorophore prepared film simultaneously harness chemical potential light aerial humidity gradients convert mechanical work strong reversible hygroscopicity agarose matrix induces swift locomotion mechanical deformation owing exchange water surroundings driven humidity composite film coupled piezoelectric bending transducer sensor generates peak output approximately corresponds power density wkg excitation light triggers isomerization chromophore appears reshaping spiraling bending twisting film material also responds changes phvalue reversible protonation fluorophore rapid changes color fluorescence threefold sensing capability smart material could utilized fabrication multiresponsive actuating dynamic elements biomedicine soft robotics
paper consider weak center conditions local critical periods equivariant cubic system eleven center conditions center using computer algebra system mathematica compute period constants obtain order weak center every center condition separately finally number local critical periods bifurcating center given symbolic computation numerical computation
although considerable body research examined impact student attractiveness instructors little attention given influence instructor attractiveness students study tested hypothesis persons would perform significantly better learning task perceived instructor high physical attractiveness test hypothesis participants listened audio lecture viewing photograph instructor photograph depicted either physically attractive instructor less attractive instructor following lecture participants completed forced choice recognition task covering material lecture consistent predictions attractive instructors associated learning finally replicated previous findings demonstrating role attractiveness plays person perception
castleman disease benign lymphoproliferative disease unknown aetiology rarely occurs head neck region herein authors describe patient intraoral management year old female patient attended clinic year history mass posterior hard palate region clinical radiographic examination cone beam computed tomography scan fine needle aspiration incisional biopsy performed radiographic examination fine needle aspiration reveal relevant findings pathological analysis biopsy gave diagnosis hyaline vascular type patient treated complete surgical resection years treatment patient remained free recurrence castleman disease hard palate quite different forms cervical mimicking conditions like pleomorphic adenoma lymphoma nodular necrotizing sialometaplasia careful clinical examination histopathological analysis essential diagnosis rare unusual pathological changes oral mucosa
tissue microarray tma technique established high throughput method analyze multiple tissue specimens parallel however order obtain reliable results immunohistochemical analyses tma blocks cell composition tma spots must correspond whole tissue sections wts particularly tissues heterogeneous cell composition case myeloproliferative neoplasms mpn aim study validate tma bone marrow biopsies mpn patients tmas mpn bone marrow biopsies pmf compiled triplicates mpn specific histological parameters assessed results tma spots compared wts results using intra class correlation coefficient icc immunohistochemical nfe calreticulin stainings tma quantitative evaluation performed tma construction technically successful loss spots icc calculation revealed high moderate correlations tma wts especially parameters typically affected mpn tissue cellularity hematopoiesis icc number megakaryocytes icc micro vessel density icc grade myelofibrosis icc results nfe calreticulin immunohistochemistry mpn tmas consistent previously published data overall results show moderate good correlation histological data wts tma spots illustrating tma technique applicable bone marrow biopsies mpn patients however tma construction triplicates necessary reach sufficient correlation mpn tmas applied serial immunohistochemical surveys archived tissues assess mutation status sub classify mpn cases
study focuses four textile industries geda noya almhadi alsar established peri urban areas dukem gelan objectives study generate baseline information regarding concentration levels selected pollutants analyze effects biophysical environments study also attempts explore level exposure humans livestock polluted effluents effects thereof findings study based data empirically collected two sources laboratory analysis sample effluents four selected textile plants quantitative well qualitative socioeconomic data collection part latter household survey focus group discussions fgds elderly focal persons employed towns dukem gelan results study show large concentrations biological oxygen demand bod chemical oxygen demand cod total suspended solids tss found observed textile industries levels beyond permissible discharge limit set national environmental protection authority epa furthermore sulfide phosphate found large concentrations geda almhadi high concentrations also identified samples taken alsar almhadi spite clear cut legal tools study shows local environment people livestock exposed highly contaminated effluents therefore recommend respective federal regional government bodies reexamine compliance actual implementation existing legal procedures regulations respond appropriately
low rank representation lrr useful tool seeking lowest rank representation among coefficient matrices represent images linear combinations basis given dictionary however unsupervised method poor applicability performance real scenarios lack image information paper based lrr propose novel semi supervised approach called label constrained sparse low rank representation lcslrr incorporates label information additional hard constraint specifically paper develops optimization process improvement discriminating power low rank decomposition presented explicitly adding label information constraint construct lcslrr graph represent data structures semi supervised learning provide weights edges graph seeking low rank sparse matrix conduct extensive experiments publicly available databases verify effectiveness novel algorithm comparison state art approaches set evaluations
rendering performance everlasting goal computer graphics significant driver advances hardware architecture algorithms thereby become possible apply advanced computer graphics technology even low cost embedded appliances car instruments yet come efficient implementation developers put enormous efforts hardware problem specific tailoring fine tuning domain exploration requires profound expert knowledge good solution found high probability work well architectures even next hardware generation generative dsl based approaches could mitigate efforts provide efficient exploration algorithmic variants hardware specific tuning ideas however vertically organized industries automotive suppliers reluctant introduce techniques fear loss control high introduction costs additional constraints imposed oem respect software tool chain certification moreover suppliers want share generic solutions oem concrete instances end propose light weight incremental approach meta programming graphics applications approach relies existing formulation like languages amenable meta programming extend become lightweight language combine algorithmic features method provides concise notation meta programs generates easily sharable output appropriate style target language
shape memory function new smart material magnetic control properties magnetic shape memory alloy could used fabricate intelligent actuators vibration control reticulated shell structure major performance parameters microstructure materials considered functional relationship magnetic field strain model traditional magnetic shape memory alloys msma magnetic field msma considered induced strain pre pressure ambient temperature factors mutual restraint relationship coupling selected nimnga paper material research deformation action temperature magnetic field pressure coupling effect according test data designed msma actuator drive
background next generation sequencing enhanced understanding biological basis malignancy current knowledge global practices sequencing cancer samples limited address deficiency developed survey provide snapshot current sequencing activities globally identify barriers data sharing use information develop sustainable solutions cancer research community methods multi item survey conducted assessing demographics clinical data collection genomic platforms privacy ethics concerns funding sources data sharing barriers sequencing initiatives globally additionally respondents asked provide primary intent initiative clinical diagnostic research combination results initiatives invited participate responded response rate whole exome sequencing whole genome sequencing utilized less frequently clinical diagnostic research initiatives procedures identify cancer specific variants heterogeneous bioinformatics pipelines employing different mutation calling variant annotation algorithms measurement treatment efficacy varied amongst initiatives time treatment recist common however parameters also employed whilst initiatives indicated data sharing scope varied number restrictions place transfer raw data largest perceived barriers data harmonization lack financial support bioinformatics concerns lack interoperability capturing clinical data likely perceived barrier data sharing larger initiatives smaller initiatives conclusions results identify main barriers perceived cancer sequencing community effective sharing cancer genomic clinical data highlight need greater harmonization technical ethical data capture processes cancer sample sequencing worldwide order support effective responsible data sharing benefit patients
background objectives two year follow study evaluated long term outcomes two early interventions aimed reducing social test anxiety young adolescents risk developing social anxiety disorder methods rcp moderately socially anxious adolescents mean age years randomly assigned week internet based multifaceted cognitive bias modification training cbm week school based cognitive behavioral group training cbt intervention control condition using multiple imputation study examined changes primary secondary outcome measures pretest follow repeated measures design results primary outcome self reported social test anxiety generally decreased pre test two year follow regardless treatment condition percentage adolescents developed social anxiety disorder low similar across conditions secondary outcome beneficial changes self esteem self reported prosocial behaviors fear negative evaluation none related treatment condition automatic social threat associations significantly change cbm intervention effective changing interpretative bias indexed recognition task long term effect transfer adolescent interpretation belief questionnaire limitations substantial though seemingly non selective attrition follow conclusions rct support longer term efficacy school based cbt cbm early intervention social test anxiety rather emphasizes positive natural course highly socially anxious adolescents two years authors published elsevier ltd
thrombocytosis defined platelets several aetiologies excluded spurious thrombocytosis due microspherocytes schistocytes cryoglobulins bacteria differential diagnosis true thrombocytosis encompasses secondary causes diverse inflammation infection malignancy iron deficiency asplenia primary hereditary rare forms familial thrombocytosis primary acquired entities either context myelodysplastic syndrome frequently myeloproliferative neoplasia manuscript addresses following aspects diagnostic approach thrombocytosis various mechanisms leading high platelet count potential mechanisms modulate platelet function producing hyperreactive platelets thus exerting direct impact thrombotic risk indication anti thrombotic treatment patients thrombocytosis single prospective randomized clinical trial showing benefit acetyl salicylic acid polycythaemia vera types primary thrombocytosis secondary forms treatment decisions individualized according patient thrombotic bleeding risks taking account mechanism causing thrombocytosis manuscript discusses experimental clinical data suggesting besides patients essential thrombocythaemia forms primary thrombocytosis also thrombocytosis context chronic inflammation malignancy exposure high altitude might benefit anti platelet treatment
opinion leaders tend possess particular characteristics high social status wide social networks highly engaged civic affairs study revisits concept original opinion leadership examines characteristics twitter opinion leaders leadership conducting online survey college students united states results reveal twitter opinion leadership rarely predicted socio demographics twitter opinion leadership strongly associated online network size offline network size study also finds twitter opinion leadership significantly positively associated online civic participation lastly current study finds twitter opinion leaders categorized two types frequent tweet posters frequent retweeters elsevier ltd rights reserved
paper presents design method flux switching permanent magnet machine reduce acoustic noise mechanical vibration main source noise vibration electric motor radial magnetic force mechanical vibrations generated electromagnetic interference harmonic components radial magnetic force mechanical resonance frequencies structures motor motor design considered reduce amplitude radial magnetic force harmonic radial magnetic force calculated finite element method maxwell stress tensor harmonic components radial magnetic force examined fourier decomposition
pilot study investigated feasibility preliminary efficacy internet support group isg parents children eligible parents recruited email completed baseline questionnaires assessing social support self efficacy depression anxiety isg involved eight weekly min chat sessions discussion forum open day weeks follow measures completed immediately post intervention months later parents families mothers fathers completed baseline measures half parents rated child disease severity mild moderate severe among parents completed post intervention measures ratings perceived emotional informational support increased significant changes self efficacy depression anxiety mean satisfaction rating moderately high range parents commented chat sessions inconvenient times may limited participation preliminary evidence small sample parents suggests isgs may feasible potentially efficacious method providing support parents children multiple weekly chat sessions held various days times may improve accessibility participation clinicians encouraged help parents access online support resources
cervical cancer one leading cancers among indian women estimated new cases deaths cervical cancer multi etiological disease factors low socioeconomic status tobacco use sexual reproductive factors hiv sexually transmitted diseases long term oral contraceptive use suggested determinants assessment socio demographic profile reproductive history gives better picture determinants cervical carcinoma low resource settings hospital based cross sectional study undertaken tertiary healthcare institute new delhi india sixty seven newly diagnosed women advanced cervical cancer stage undertaking radio chemotherapy included assess socio demographic reproductive clinical profile mean age women time detection cervical cancer years range years patients illiterate belonged middle socioeconomic status thirty nine percentage study subjects first sexual experience years age nearly women pregnancies nearly women deliveries home majority women symptoms suggestive reproductive tract infection among unusual discharge vagina followed bleeding menopause pain abdomen common presenting complaints pallor present nearly two third study subjects half study subjects moderate anemia severe anemia treatment mean hemoglobin level study subjects treatment treatment difference statistically significant around study subjects squamous cell carcinoma cervix majority study subjects stage cervical cancer combination radiotherapy chemotherapy common modality treatment illiteracy low socioeconomic status early sexual debut high fertility home delivery reproductive tract infections use insanitary clothes menstruation anemia observed majority women advanced cancer cervix presence factors indicates possible risk cervical cancer kept mind women seek health services early diagnosis high risk opportunistic screening timely management cervical cancer needs ensured better outcomes
whether indoor painting aggravates preexisting allergic diseases remains unclear aimed evaluate impact new classroom painting aggravation asthma allergic rhinitis atopic dermatitis children studied school previously painted conventional water based paint years ago natural ventilation system identified total children aged years allergic diseases classrooms allocated newly painted rooms low volatile organic compounds voc water based paint existing rooms painting intervention internal airflow influence indoor air environment classrooms prospectively assessed symptom severity serious events allergic diseases classrooms baseline one eight weeks painting one eight weeks significant changes childhood asthma control test scores fractional nitric oxide levels lung function asthmatic children either classroom also significant changes severity score serious events allergic diseases findings suggest classroom painting new paint levels encountered study might major aggravating factor school aged children allergic diseases
background objectivedetermination asthma phenotypes particularly inflammatory phenotypes helps guide treatment management heterogeneous disease induced sputum cytology gold standard determination inflammatory phenotypes sputum induction fairly invasive technically challenging blood nasal lavage cytology suggested substitutes fully verified aim study determine accuracy blood nasal lavage cytometry indicators inflammatory phenotypes asthma methodsclinical evaluation asthma control questionnaire acq spirometry performed adult asthma patients blood nasal lavage induced sputum samples taken eosinophils neutrophils counted three samples subject inflammatory phenotypes eosinophilic neutrophilic mixed paucicellular cells counts analysed using venn diagram receiver operating characteristic roc curve respectively results acq score spirometry bronchodilator response differ among subjects different inflammatory phenotypes inflammatory phenotypes defined nasal lavage cytometry better concordance defined blood cell counts phenotypes determined sputum cytology significantly correlated sputum phenotypes eosinophilia nasal lavage cytology showed better accuracy blood cytology area curve auc phenotypes sensitivity positive negative predictive power higher nasal lavage cytometry blood blood cell counts gave high level false positives inflammatory phenotypes conclusionwe recommend nasal lavage cytology blood cell count substitute sputum cytology identify inflammatory phenotypes asthma
solve problems climate change every little push counts community energy schemes popular policy targeted reduce country carbon emissions effect energy use depends whether people work together community often find caught dilemma others bit experiment participants matched groups play collective risk game framed community energy purchase scheme made one decision energy use virtual household day full round game lasted week real time decisions entered via personal phone home computer end week group exceeded pre paid threshold energy use group members would share fine day participants received feedback decisions group partners groups feedback manipulated high unfair condition low fair condition use high average group use created individual risk participants penalized end week even use much found risk pay fine participants stayed significantly fair share threshold regardless unfair behavior others contrary significantly decreased consumption toward end game seeing others bit using fair share encouraged people take advantage situation played fair confederates follow normative behavior conversely increased consumption course game opportunistic strategies demonstrated impulsive participants also low punishment sensitivity discuss findings light policy research well literature cooperation prosocial behavior
objectives treatment inflammatory bowel disease ibd revolutionized use immunomodulatory agents although potent drugs effective controlling disease activity also cause increased risk new infections reactivation latent infections premises aimed provide guidance definitions immunocompromised patients opportunistic infections risk factors associated occurrence ibd context suggest proper screening tests infectious diseases vaccination schedules perform therapy immunomodulators methods recent evidences filtered combined work gastroenterologists infectious disease experts summarized aim provide practical standpoint physician results systematic screening infections may arise therapy immunomodulator drugs necessary patients ibd conclusions ideal timing perform screening tests vaccinations diagnosis disease regardless severity onset course ibd treatment may vary time immunocompromised status may hamper efficacy possibility perform necessary vaccines british infection association published elsevier ltd rights reserved
cluster analysis clustering task grouping set objects way objects group called cluster similar sense another groups clusters main task exploratory data mining common technique statistical data analysis used many fields including machine learning pattern recognition image analysis information retrieval bioinformatics data compression computer graphics
wind velocity power spectrum wvps high fidelity extremely important accurate prediction structural buffeting response wvps heavily depends geographical locations local terrains topographies hence field measurement wind characteristics may unique way obtain accurate wvps specific region paper systematic analysis discussions existing wvpss performed six recorded strong wind data structural health monitoring systems shms runyang suspension bridge rsb sutong cable stayed bridge scb jiangsu province china selected analysis measured pre processed wind velocity data first transformed time domain frequency domain obtain measured spectrum spectrum strong wind fitted using nonlinear least square method compared fitted spectrum statistical analysis recommended spectrum specifications modified kaimal spectrum proved best choice coastal area east jiangsu province finally suitable wvps formula fit coastal area east jiangsu province presented based modified kaimal spectrum results study provide accurate reliable wvps wind resistant design engineering structures coastal area east jiangsu province
target collaborative project involving partnership universities institutes higher education ireland norway finland sweden project develop tools enhance capacity regional manufacturing companies adapt embrace new technologies innovation done collaboration small medium sized manufacturing engineering companies developing applying piloting tools individual companies processes toolbox developed consist subsets digital manufacturing robotics simulation new ideas thinking human centred environmental thinking competitiveness business models modern product innovation completion project toolbox supports made available use open access manufacturing companies initial project phase development toolbox suitable use project partners regions presented
lower urinary tract symptoms luts common parkinson disease effecting patients irritative symptoms predominate urodynamic studies confirm high prevalence detrusor overactivity luts present early common age matched controls assessment luts complicated coexisting bradykinesia cognitive impairment although luis become troublesome progresses remains unclear luts severity correlates motor symptoms duration underlying cause luts remains fully elucidated animal human studies suggest net effect basal ganglia supress micturition although luts common studies examined assessment management luts specifically patients pilot studies suggested bladder training antimuscarinic drugs intravesical botulinum toxin maybe helpful trials small frequently lacked suitable control group making vulnerable placebo effect furthermore adverse effects antimuscarinic drugs cognitive gastrointestinal function may limit use drugs review summarise literature describing prevalence luts discuss emerging data delineating underlying pathophysiology luts examine interventions helpful management luts people published elsevier ltd
seawater viscosity influenced temperature well excretion exopolymers plankton examined role viscosity movement patterns sensory abilities dinoflagellate heterocapsa triquetra manipulating viscosity seawater simulate degrees temperature change second treatment seeded water microbeads examine swimming behaviours presence mechanical stimulus increased viscosity reduced distances conspecifics fold increased distances protists microbeads fold increased viscosity also affected aspects motility overall reduction swimming speed fold treatments without mechanical stimuli higher viscosities associated upward vertical migration presence absence microbeads cells highly sensitive disturbances velocity field little different approach distances triquetra conspecifics mechanical stimuli suggest sensory capacity distinguish types particles mediation motility migratory behaviours viscosity implies ramifications distribution protists encounters resources predators conspecifics triggered events temperature changes phytoplankton bloom events
introduction psoriasis chronic inflammatory disorder significant morbidity mortality persistent gap appears exist adequate treatment patients moderate severe disease extent treatment unknown attempted determine overall treatment patterns estimate treatment using large database methods data national health wellness survey used estimate proportion patients mild moderate severe psoriasis proportion moderate severe disease estimated excluding mild disease projecting total insured population weighted age gender using health plan claims data patient totals treatment type determined october september patients continuously enrolled health plan years end analysis window psoriasis confirmed patients least one claim type psoriasis except psoriatic arthropathy icd code monthly treatment history classified biologic traditional oral systemic phototherapy topical therapy recorded patient results estimated million insured patients moderate severe psoriasis million treated condition preceding year among patients treated psoriasis preceding year currently receiving treatment lapsed treatment patients lapsed currently treated period numbers received treatment type biologic traditional oral systemic phototherapy topical limitation study insurance claims analyzed conclusion moderate severe psoriasis remains persistently untreated treated suggest potential barriers preventing access care explored
introduction increase number mentally demanding jobs well increase work performed sedentary growing imbalance use body resources often results increase fatigue working population diversity workforce also increasing whereas physiological differences based culture important consider objective study identify differences levels fatigue workplace experienced asian western workers mentally demanding jobs method eight asian eight western participants completed observation based study participant observed four hours workplace working highly mentally demanding work tasks either computer programming mathematical simulations balance effect time half participants ethnic group observed morning session half afternoon session perceived fatigue measured every min using single dimensional borg multidimensional sofi scales workload measured using nasa tlx change resting heart rate result ethnicity time interacted significantly affect perceived fatigue measured borg sofi scales asian participants reported significantly higher workload measured nasa tlx scores change resting heart rate measured higher compared western participants unlike fatigue significant interactions observed time ethnicity affect either nasa tlx scores change resting heart rate post hoc analyses show rate fatigue higher asian participants correlations dependent variables significant stronger correlation identified asian participants conclusion compared western participants asian participants reported higher values dependent measures including fatigue scales nasa tlx scores change resting heart rate relevance industry significant growth white collar well mentally demanding jobs requires cognitive resources reducing physical activities consequences imbalances use body resources yet studied study designed investigate issues imbalance workplace elsevier rights reserved
purpose dialectical behaviour therapy dbt widely used number different settings published outcomes literature supporting validity efficacy less understood dbt application forensic populations purpose paper qualitatively explore experiences high risk adult male forensic clients diagnosed borderline personality disorder bpd antisocial personality disorder aspd forensic adapted version dbt design methodology approach six clients completed four modules dbt individual therapy engaged semi structured interviews transcribed analysed using thematic analysis findings findings identified emerging themes relating group processes treatment outcomes specifically importance motivation shared learning professionalism reinforcement reflection creating positive experience dbt identified addition clients identified feeling supported sense belonging personal achievement increased knowledge skills application part experience dbt research limitations implications whilst efforts made manage limitations potential confounders include impact researcher direct involvement facilitation dbt small sample size practical implications study provides support use dbt forensic males diagnosed aspd bpd importance group component treatment modality emphasises importance group cohesion development interpersonal factors including feeling supported sense belonging sense achievement originality value paper provides unique contribution understanding application dbt forensic male clients personality disorder first known study use qualitative methods explore forensic male clients experiences group individual dbt paper provides insight key themes clients experiences dbt identified themes lend support importance motivation clients experience shared learning reinforcement reflection furthermore feeling supported sense belonging sense personal achievement identified key positive experience clients
paper presents idea combine set software hardware resources available literature used support control engineering education available tools allow mix topics related programming communications operating systems control theory well known raspberry board used platform exploit erent proposed concepts scipy matplotlib numpy libraries python based open source libraries scienti computing graphical representation used perform matlab like simulations implement classical control loops hand virtual processes developed easy java simulations adapted controlled network controller implemented raspberry python option useful teaching point view since time based networked based event based control approaches easily introduced proposed architecture furthermore students know implement control loops raspberry using python external real processes easily controlled using gpio interface available electronic board project based tools ideas motivated presented paper control two tank level process copyright ifac ifac international federation automatic control hosting elsevier ltd rights reserved
defense reactions threatening situations vital adaptations stress protect organisms injury ensure survival retrospectively investigated role peritraumatic dissociation occurrence severe psychopathology dissociative patterns reactions borderline personality disorder bpd recruited patients clinical diagnosis bpd healthy controls bpd group divided according level low high bpd bpd conducted extensive investigation history trauma clinical status measurements emotional physiologic responses recall personalized aversive experiences participants bpd high displayed highest degrees trauma exposure clinical symptoms significant heart rate decline imagery personal traumatic events opposed heart rate increases exhibited two groups may indicate dissociative reaction pattern skin conductance responses differentiate groups several emotional responses imagery also reinforced idea may play role memory processing traumatic events thus aggravation maintenance symptoms particularly severe forms bpd within stepwise linear regression analysis best model trauma evoked heart rate responses included borderline symptoms measures state trait dissociation findings may provide initial evidence evolutionary model peritraumatic reaction stages evolving arousal dissociation
eutectic naco lico salt widely used electrolyte molten carbonate fuel cell high ionic conductivity operating temperature major objective study investigate thermal stability binary salt phase change material thermal energy storage thermal decomposition analysis different environments thermal cycling composition binary salt determined using factsage software thermophysical properties experimentally investigated using simultaneous thermal analyzer ray diffraction results show eutectic naco lico salt melting solidification point degrees degrees heat fusion jig heat solidification thermal decomposition analysis indicates eutectic molten salt good thermal stability environment without weight loss temperatures degrees however weight loss observed degrees atmosphere associated thermal decomposition eutectic salt produce corresponding metal oxides environment could inhibit thermal decomposition thus resulting higher thermal stability binary salt hence operating environment large effect thermal stability eutectic naco lico salt eutectic salt exhibits high thermal stability thermal cycles little change thermal properties compared initial sample published elsevier
purpose review atrial fibrillation important cause morbidity aging population mechanisms responsible triggering maintenance chaotic atrial rhythm still poorly understood review focus genetic aspects atrial fibrillation understand causality special emphasis recent studies published field recent findings diseases hypertension valvular heart disease heart failure may induce atrial fibrillation increases risk stroke sudden cardiac death clinical studies published last two decades provided evidence genetics play key role atrial fibrillation thus family history disease identified clinically diagnosed patients genotyped families carry rare genetic variants genes associated ionic channels calcium handling protein predisposing fibrosis conduction system disease inflammatory processes summary currently atrial fibrillation common sustained arrhythmia clinical practice pathophysiological mechanisms atrial fibrillation complex better understanding molecular basis help improve current risk stratification clinical management
ionic composition intracellular space rigorously maintained expense high energy expenditure recently postulated cytoplasmic ionic composition optimized energy cost fluctuations calcium ion concentration minimized specifically thermodynamic arguments produced show presence potassium ions concentrations higher reduce extend energy dissipation required dilution calcium cations effect measured sodium ions present solution divalent cation magnesium diluted experimental observation interpreted indication formation ionic clusters composed calcium chloride potassium order test possibility clusters may preserved biological space thermodynamics ionic mixtures dilution solutions containing albumins model lipid bilayers measured obtained thermograms clearly demonstrate energetics calcium potassium mixture qualitatively different calcium sodium mixture indicating presence biologically relevant quantities proteins membrane hydrophilic surfaces interfere properties intracellular aqueous phase
diabetes mellitus highly prevalent condition affecting million people worldwide addition numerous clinical implications also exerts negative effect patient sleep quality impaired sleep quality disrupts adequate glycemic control regarded corner stone management also lead many deleterious effects causing profound impact health related quality life article outlines various factors leading impaired sleep quality among diabetics delineates individual factor influences sleep article also discusses potential interventions lifestyle changes promote healthy sleep among diabetics
parental sense competence one central dimensions targeted psychosocial interventions aimed supporting risk families researchers practitioners need reliable instruments assess parental role adapted families although parental sense competence psoc scale frequently used assess construct still adapted version portuguese parents study reliability validity factor structure psoc scale examined clinical sample mothers risk families receiving psychosocial interventions family preservation child protective services results show portuguese version psoc measures three distinct constructs acceptable psychometric properties efficacy dissatisfaction controllability expected obtained factors significantly positively related parenting alliance family cohesion negatively associated parenting stress sum proposed portuguese version shows reliability validity evidences measure three relevant dimensions parental self evaluation constitutes cost time effective instrument suited risk mothers
difficulties emotion regulation behavioral instability including impulsive aggression seen core dimensions underlying borderline personality disorder bpd although bpd antisocial personality disorder aspd associated impulsivity aggressive behavior difficulties regulating emotions may associated uniquely bpd may explain distinctive associations bpd aggression study designed examine unique prospective associations bpd symptoms baseline difficulties emotion regulation trait impulsivity psychological physical aggression perpetration victimization course year controlling aspd symptoms mixed clinical community sample adults results multivariate path analysis demonstrated associations bpd symptoms baseline later psychological physical aggression fully mediated difficulties emotion regulation although bpd symptoms also predicted trait impulsivity impulsivity predict aggression controlling emotion dysregulation aspd symptoms directly associated physical assault perpetration victimization associated emotion dysregulation impulsivity psychological aggression findings suggest although bpd aspd associated aggressive behaviors associations bpd symptoms aggression mediated uniquely difficulties regulating emotions
objective methamphetamine usage recognized prominent substance abuse issue exercise training reportedly improves fitness mental status dependent exercise training affects addiction cognitive deficiency yet established current study aimed determine effects aerobic exercise training associated cravings inhibitory control among dependencies design week randomized controlled trial method sixty two people dependencies recruited drug rehabilitation bureau assigned either aerobic exercise attentional control group participants completing trial aerobic exercise program involved three min sessions moderate intensity exercise per week along pre test assessment craving levels evaluated every three weeks data neutral related inhibitory control well elicited neuroelectric activation collected end intervention results compared control group exercise group experienced attenuated craving levels weeks exercise program decreased trend maintained termination treatment post test exercise group also demonstrated accuracy behavioral inhibitory control well greater amplitude nogo condition standard related tasks control group pre test conclusions current study provides first evidence aerobic exercise training may efficacious associated cravings inhibitory control behavioral neuroelectric perspectives among dependent individuals published elsevier ltd
today transfer function two nodes linear flowgram obtained either applying step step classical elimination nodes branches applying mason rules manual tedious many cases procedures therefore prone human errors paper facilitate derivation transfer function two different ways first one consists reducing possible flowgram obtaining manually simpler equivalent subflowgram apply mentioned procedures thus time elapsed process well probability mistakes commission diminishes second way consists deriving transfer function using user friendly software developed paper apply automatic form mason rules flowgram study derive possible transfer function without errors short process time case software works equivalent subflowgram obtained computer process form manually obtained finally apply tool presented examples biological systems elsevier inc rights reserved
since introduction spice non linear controlled voltage current sources become central feature interactive development behavioural device models circuit macromodels current generation spice based open source general public license circuit simulators including qucs ngspice xyce implements range mathematical operators functions modelling physical phenomena system performance qucs equation defined device extension spice style non linear type controlled source adds dynamic charge properties behavioural sources allowing example voltage current dependent capacitance easily modelled following standardization verilog become preferred hardware description language analogue models written netlist format combined general computer programming features sequencing controlling model operation traditional circuit simulation generation verilog model schematic embedded non linear behavioural sources automatic normally undertaken manually paper introduces new approach generation verilog compact device models qucs circuit schematics using purpose built analogue module synthesizer illustrate properties use qucs verilog module synthesiser text includes number semiconductor device modelling examples cases compares simulation performance conventional behavioural device models copyright john wiley sons ltd
precision rectifiers important building blocks analog signal processing traditional approach based diodes operational amplifiers opamps exhibits undesirable effects caused limited opamp slew rate diode commutations paper full wave rectifier based one cdta two schottky diodes presented pspice simulation results included
purpose using academy nutrition dietetics benchmarks framework study examined childcare providers head start child adult care food program cacfp funded non cacfp perspectives regarding communicating parents nutrition promote children health design qualitative setting state licensed center based childcare programs participants full time childcare providers caring children years old varying childcare contexts cacfp funded non cacfp race education years experience methods person interviews using semi structured interview protocol saturation achieved thematic analysis conducted results two overarching themes barriers strategies communicate parents children nutrition barriers communication included parents busy talk providers parents offer unhealthy foods parents prioritize talking child food issues nutrition providers unsure communicate nutrition without offending parents providers concerned parents receptive nutrition education materials strategies communication included recognize benefits communicating parents nutrition support child health build partnership parents education leverage policy federal state communicate positively avoid conflict implement center level practices reinforce policy foster respectful relationship providers parents conclusion policy environmental changes recommended fostering respectful relationship building bridge providers parents improve communication children nutrition health
visual object tracking technology one key issues computer vision paper propose visual object tracking algorithm based cross modality featuredeep learning using gaussian bernoulli deep boltzmann machines dbm rgb sensors first cross modality featurelearning network based agaussian bernoulli dbm constructed extract cross modality features samples rgb video data second cross modality features samples input logistic regression classifier andthe observation likelihood model established according confidence score classifier finally object tracking results rgb data obtained using abayesian maximum posteriori map probability estimation algorithm experimental results show proposed method strong robustness abnormal changes occlusion rotation illumination change etc algorithm steadily track multiple targets higher accuracy
widely accepted developing ability solve problems essential computational thinking based problem solving using basic concepts computing introductory course programming direct way develop ability solve problems using computer concepts paper presents thinking initiating students field computer programming work detail contents taught focuses methodological aspects including experiences specific examples general extensible programming course although programming languages developed increasingly closer human language computer programming using formal languages intuitive easy understood students may seem simple task experienced programmer neophyte moreover mastering art programming complex reason essential use possible techniques tools facilitate work
paper describes extrusion based additive manufacturing process developed enable embedment sapphire optical fiber sensors ceramic components part fabrication process aqueous paste ceramic particles extruded moving nozzle build part layer layer case sensor embedment fabrication process halted certain number layers deposited sensors placed predetermined locations remaining layers deposited part fabrication completed sensors embedded fabrication process fully integrated part problems traditional sensor embedment eliminated scanning electronmicroscopy used observe embedded sensors detect possible flaws part embedded sensor attenuation sensors measured near infrared region wavelength standard test methods employed examine effect embedded fibers strength hardness parts results indicated sapphire fiber sensors diameters smaller micrometers able endure freeform extrusion fabrication process post processing without compromising part properties published elsevier ltd
improve energy conversion ability well utilize renewable resources rifkin first put forward concept internet energy ioe although peer peer energy sharing mechanism achieved directional energy transportation approach solving cooperative energy transportation storage still needs improving traditionally redundant energy wasted consumed power load fact redundant energy stored supply power loads future end investigate cooperative energy transportation storage ioes terms problem analysis algorithm design platform development demonstrating feasibility condition proving hard problem derive optimal solution reduction classic knapsack problem also design novel heuristics followed different energy storage strategies addition based software defined networking sdn complementary platform developed make effective decision cooperative energy transportation storage using heuristics simulation experimental results demonstrate effectiveness solutions
background idiopathic pulmonary fibrosis ipf relentless progressive interstitial lung disease evaluating predictor mortality ipf patients crucial aim study evaluate serial trend important indicators prognosis create useful staging method ipf patients methods retrospectively searched medical records pulmonary function tests pfts chest high resolution computed tomography hrct scans january june hospital also evaluated parameters year later results identified ipf patients mean age years range years terms pfts mean percent predicted forced vital capacity fvc baseline mean body mass index bmi mean survival months range months cox proportional hazard ratios hrs showed following predictors mortality ipf patients year bmi year fvc year respiratory hospitalization basis date created new staging method predicting mortality ipf patients consisting delta bmi delta fvc respiratory hospitalization within year following diagnosis ipf bfr staging stratified patients one three groups according composite points mean survival stages months respectively conclusions cohort ipf patients new staging method including delta bmi delta fvc respiratory hospitalization within year showed clear survival difference
aim work design robust control algorithms aerial robots quadrotors team transportation deformable linear object dlo dlo robot attachment makes whole system physically coupled elastic element introduces strong non linearities system dynamics sections quasi stationary state dlo hanging freely two extreme points modeled catenary curves able build detailed accurate simulation system workbench evaluation alternative quadrotor control approaches dlo transportation instance follow leader team strategy local quadrotor control must cope dynamic perturbations due dlo linking quadrotors quadrotor team control two phases one achieving spatial configuration equal energy consumption manage horizontal motion transportation process per paper deal second control problem assuming first solved use proportional derivative controllers quadrotor attitude trajectory control offline parameter setting carried metaheuristic optimization cope perturbations induced dlo environmental conditions wind shear therefore propose adaptive controller quadrotors carrying dlo transportation task uses fuzzy modeling error order modulate activation parameters adaptation rules error gradient descent rules computational experiments system simulation workbench show adaptive approach scales well increasing number quadrotors providing smooth follow leader team strategy navigation behaviors even strong wind perturbation conditions compare approach state art online offline approaches
paper present new control theoretic framework efficiently design balanced coordinated resource allocation algorithms network based semistabilization theory discrete time stochastic linear systems together compartmental modeling specifically necessary sufficient conditions equivalent control theoretic characterizations proposed balanced coordinated resource allocation design problem derived based new notion semiobservability new semistable lyapunov equation theory first unveil striking connection balanced coordinated network resource allocation design problem optimal semistable control theory means stochastic optimal semistable control technique convert optimal control based design problem constrained nonlinear optimization problem look possible numerical solutions original balanced coordinated resource allocation algorithm design problem end propose class randomized swarm optimization based numerical algorithms called multiagent coordination optimization solve constrained nonlinear optimization problem finally numerical results provided validate proposed design framework application target search problem threat detection resource allocation presented show effectiveness proposed approach
new anti fibrotic agents idiopathic pulmonary fibrosis ipf approved based results forced vital capacity fvc trends although concerns raised reliability fvc endpoint parameter hypothesized ipf specific multi dimensional scores composite physiologic index cpi gender age physiology gap risk stratification score rise would better capture response therapy pilot study treated untreated cohorts ipf patients matched demographic functional characteristics prospectively followed year month intervals progression free survival significantly improved treated patients difference fvc longitudinal trends observed mrc dyspnea score diffusing lung capacity min walk distance cpi rise significantly stabilized treated patients compared steady worsening untreated subjects multi dimensional scores provide broader spectrum prognostic information may facilitate assessment efficacy new drugs ipf
simulations classroom games effective hands learning tools construction management students practitioners paper presents background methods results new simulation management game called lebsco simulates aspects last planner system lps lean production principles lps central implementation lean construction increasingly popular management approach based toyota production system lean production lps requires continuous collaborative effort stakeholders planning control construction project making especially appropriate experiential learning allowed simulation lebsco consists assembly lego pieces form schematic house played teams meeting rounds simulating weeks work team composed stakeholders planner resource suppliers trade foremen mirroring planning control process typical construction project participants build lego houses first using traditional management approach using lean based approach graduate course construction management university auckland new zealand used case study test effectiveness lebsco teaching method implementation results lesbco demonstrated capability transfer disseminate lean based knowledge construction american society civil engineers
bone constant state remodeling process attributed solely osteoblasts osteoclasts decades research identified many populations cells bone participate mediate skeletal homeostasis recently osteal macrophages emerged vital participants skeletal remodeling osseous repair exact mechanistic roles tissue resident macrophages currently investigation macrophages highly plastic response micro environment typically classified pro anti inflammatory pro resolving nature given inflammatory states result decreased bone mass proinflammatory macrophages may negative regulators bone turnover pro resolving macrophages shown release anabolic factors may present target therapeutic intervention inflammation induced bone loss fracture healing process apoptotic cell clearance termed efferocytosis mediated pro resolving macrophages may contribute steady state bone turnover well fracture healing anabolic effects osteoporosis therapies parathyroid hormone anabolic agent bone effective presence mature phagocytic macrophages supporting hypothesis efferocytic macrophages positive contributors bone turnover therapies alter macrophage plasticity tissues bone explored potential treat bone loss either alone conjunction current bone therapeutics better understanding exact mechanisms macrophages mediate bone homeostasis lead expansion pharmacologic targets treatment osteoporosis inflammation induced bone loss elsevier inc rights reserved
surgical approaches endometriosis patients chronic pelvic pain multimodal require individualization laparoscopic approaches preferred laparotomy conservatively treating endometriosis via excision ablation fulguration lesions available data support cystectomy fenestration fulguration endometriomas however may associated decreases ovarian reserve endometrioma treatment presacral neurectomy may useful patients midline pain luna effective treatment pelvic pain related endometriosis appendectomy may considered prophylactically time surgery pelvic pain although studies needed deep infiltrating endometriosis risks aggressive bowel surgery must weighed benefits clear pain reduction postoperative medical suppressive therapy strongly recommended prolong symptom free intervals chronic disease definitive therapy hysterectomy helpful especially combined endometriosis excision performing hysterectomy bilateral oophorectomy given careful consideration procedure leads premature surgical menopause may decrease possibility reoperation persistence symptoms patients aged years chronic pain
background hyperglycemia associated adverse pregnancy outcomes however relationships remain ambiguous study aimed analyze effect different oral glucose tolerance test ogtt results adverse perinatal outcomes methods retrospective cohort study included data hospitals beijing june november women gestational diabetes mellitus gdm categorized according number distribution abnormal ogtt values characteristics adverse pregnancy outcomes evaluated chi square test logistic regression analysis used determine associations results total pregnant women included study population gdm number hyperglycemic values ogtt increased risk cesarean delivery preterm births large gestational age lga macrosomia neonatal complications significantly increased fasting hyperglycemia clear associations macrosomia odds ratios ors confidence intervals cls lga cesarean delivery associations stronger fasting glucose increased gdm diagnosed hyperglycemia ogtt likely lead preterm birth conclusions various characteristics ogtts associated different adverse outcomes careful reconsideration gdm hierarchical individualized management according ogtt characteristics needed
also known obinutuzumab gazyva gazyvaro glycoengineered type humanized antibody targets antigen expressed surface cells novel anti antibody currently assessed clinical trials promising results single agent part therapeutic combinations treatment cell malignancies detailed understanding mechanisms induced cell death needed get insight possible resistance mechanisms occurring patients although multiple vitro vivo mechanisms suggested describe effects cells currently available data ambiguous aim study clarify cellular mechanisms involved induced cell death vitro particularly respective roles played lysosomal mitochondrial membrane permeabilization results confirm previous reports suggesting triggers homotypic adhesion caspase independent cell death two processes dependent actin remodeling involve production reactive oxygen species respect lysosomal membrane permeabilization lmp data suggest lack specificity available antibodies directed cathepsin may confounded previously published results possibly challenging current lmp driven model action mode elsevier ltd rights reserved
although efforts directed toward advancement women science technology engineering mathematics stem positions little research directly examined women perspectives bottom strategies advancing malestereotyped disciplines present study utilized photovoice participatory action research method identify themes underlie women experiences traditionally male dominated fields photovoice enables participants convey unique aspects experiences via photographs depth knowledge community personal narrative forty six stem women graduate students postdoctoral fellows completed photovoice activity small groups presented photographs described experiences pursuing leadership positions stem fields three types narratives discovered classified career strategies barriers achievement buffering strategies methods managing barriers participants described three common types career strategies motivational factors including professional development collaboration social impact moreover lack rewards workplace activities seen limiting professional effectiveness terms barriers achievement women indicated recognized authority figures often worked build legitimacy fostering positive relationships women vigilant people perspectives costly terms time energy manage role expectations including related gender participants engaged numerous role transitions throughout day accommodate workplace demands buffer barriers achievement participants found resiliency feelings accomplishment recognition social support particularly mentors helped participants cope negative experiences envision future within field work life balance also helped participants find meaning work sense control lives overall common workplace challenges included lack social capital limited degrees freedom implications organizational policy future research discussed
hnrnp proteins initially discovered regulators alternative splicing process controlled removal introns selective joining exons multiple transcripts subsequently proteins expressed single gene alternative splicing affects genes involved crucial cellular processes including apoptosis cancerogenesis impaired apoptotic control facilitates survival cells bearing molecular aberrations contributing unrestricted proliferation chemoresistance apparently hnrnp proteins regulate levels expression apoptotic genes including transcription initiation elongation alternative splicing mrna stability translation protein degradation frequently disturbed expressions hnrnp proteins cancers lead impaired functioning target apoptotic genes including regulators extrinsic fas caspase caspase flip intrinsic pathway apaf caspase icad genes encoding bcl proteins iaps tumor suppressor prototypical members hnrnp families srsf hnrnp promote synthesis anti apoptotic splice variants bcl results attenuation programmed cell death breast cancer chronic myeloid leukemia hnrnp proteins significantly affect responses chemotherapy acting mediators modulators drug induced apoptosis aberrant expression srsf hnrnp interfere tumor responses chemotherapy pancreatic liver cancers currently number splicing factor inhibitors tested pre clinical clinical trials review discuss recent findings role hnrnp proteins apoptotic control cancer cells well significance anticancer treatments elsevier rights reserved
castration male pigs common practice used reduce boar taint commercial pork production also significantly results fat accumulation carcass previous study revealed mirna gene ssc mir implicated adipogenesis however relationship ssc mir fat deposition due castration unknown present study observed ssc mir targets coding sequence cds region mark based bioinformatics analysis dual luciferase assays experiments using silent mutations sub cloning showed ssc mir binds independently two adjacent sites mark cds subsequently ssc mir inhibits mark protein expression pig fibroblast cells consistent targeting demonstrated vitro found higher mark protein levels back fat castrated pigs intact pigs providing evidence mark involved regulation fat deposition addition one snp mark significantly associated back fat trait chinese european pig populations taken together would conclude ssc mir targets mark gene fat accumulation castrated male pigs
one significant reliability issues switching mode power supplies electrolytic capacitor degradation caused aging paper proposes output voltage transient analysis method detect capacitor wear output stage step converter changes converter output voltage dynamics evaluated analyzing output voltage step response respect decrease capacitance sensitivity method assessed respect parameter variations using equivalent main circuit model feasibility presented method verified experimental tests using converter prototype results show presented method practical adequate detecting capacitor degradation various operating conditions
spectral theory many applications several main scientific research areas structural mechanics aeronautics quantum mechanics ecology probability theory electrical engineering among others importance study globally acknowledged recent years several software applications made available general public extensive capabilities symbolic computation applications known computer algebra systems cas allow delegate computer significant part symbolic calculations present many mathematical algorithms work use cas mathematica implement first time computer analytical algorithms developed others within operator theory main goal paper show symbolic computation capabilities mathematica allow explore spectra several classes singular integral operators one dimensional case nontrivial rational examples computed automated process called aspecpaired scalar presented matrix case nontrivial essentially bounded rational examples computed analytical algorithms afact sint aspecpaired matrix presented cases possible check considered paired singular integral operator complex number chosen arbitrarily belongs spectrum
overall aim study specifically investigate young adults make use emotional relational food memories related significant others childhood trying build resilience solve developmental tasks period life theoretical sample three semi structured interviews drawn larger sample interviews young adults sweden formed basis analysis guided steps phenomenologically oriented critical narrative analysis results illustrate three different overall directions relationship food evolve throughout life among young adults relationship dominated positive emotional food memories associated use food secure base negative emotional food memories associated either emotionally preoccupied food orb dismissing food results suggest internalised memories related food associated positive emotions used build resilience helping young people adapt better manage developmental stress internalised food memories related negative emotions cause vulnerability also become object person reconstruction implications potential risks using food practice developing resilience healthy lifestyle discussed elsevier ltd rights reserved
using unique microsimulation tool teen familyscape present study explores changes mix contraceptive methods used teens contributed decline teen pregnancy rate results indicate changes contraceptive use contributed approximately half decline teen pregnancy rate time period little half contraceptive effect due increase teen condom use remaining share contraceptive effect attributed increase use effective hormonal pill patch ring long acting reversible contraceptive larc injectable methods intrauterine devices iud implant injectable results additional counterfactual analysis suggest contraceptive effect driven fact percentage teens using birth control fell study time period rather fact teens switched less effective methods condoms effective hormonal larc injectable methods however high typical use failure rates teen condom users suggest need two pronged approach continuing reductions teen pregnancy sexually active teens first targeting youth risk using contraception helping choose contraception second increasing effectiveness method use among existing contraceptors
greater trochanteric pain syndrome gtps common clinical entity effective treatment local corticosteroid injection lci studies effect lci among patients gtps hypothalamic pituitary adrenal axis present study recruited nonselected patients diagnosed gtps consenting participants received low dose adrenocorticotropin hormone acth stimulation test immediately following test participants received lci methylprednisolone acetate greater trochanteric region acth stimulation test repeated weeks following lci cortisol samples obtained prior basal min post stimulation following every acth stimulation test serum cortisol levels mol obtained min following acth stimulation test considered evidence secondary adrenal insufficiency study enrolled patients completed participation female participants similar mean age participants years four participants showed evidence secondary adrenal insufficiency observed weeks following lci mean serum cortisol level among four participants min following acth stimulation test mol range mol lci methylprednisolone acetate greater trochanteric area among patients gtps associated transient secondary adrenal insufficiency similar patients mainly week following injection
rapid prototyping may beneficial properly selected cases complex congenital heart disease providing detailed anatomical understanding helps guide potential surgical cardiac catheterization interventions present case double outlet right ventricle decision obtain three dimensional printed model helped better understanding anatomy additional advantage surgical simulation planning surgical approach type surgical repair
address issue large scale network security known traditional game theory becomes intractable considering large number players realistic situation today networks centralized administration available propose new model based mean field theory allows obtain optimal decentralised defence policy node network optimal attack policy attacker way settle promising framework development mean field game theory large scale network security also present case study experimental results
combined oral contraceptive pill cocp implicated development number chronic pain conditions modern cocp formulations produce low endogenous estradiol low progesterone environment similar early follicular phase natural menstrual cycle variable effect serum androgen levels used behavioural measures functional magnetic resonance imaging investigate response experimental thermal stimuli healthy women natural cocp induced low endogenous estradiol state investigate whether alterations central pain processing may underlie observations cocp users although cocp users overall require lower temperatures obtain fixed pain intensity alterations brain response stimuli observed subgroup cocp users significantly reduced serum testosterone however lower temperatures required region interest analysis revealed within key regions descending pain inhibitory system activity response noxious stimulation varied serum testosterone levels groups women particular interest cocp users activity rostral ventromedial medulla increased increasing testosterone women low testosterone significantly reduced compared controls findings suggest low endogenous estradiol state testosterone may key factor modulating pain sensitivity via descending pathways specifically failure engage descending inhibition level rostral ventromedial medulla may responsible reduction temperature required cocp users low circulating testosterone international association study pain published elsevier rights reserved
reconfigurable magnetic coupling thruster rmct enabling technology achieving vectorial thrust auvs allows dispose dynamic compliant secure propulsion enhance agility demanding locomotion tasks rmct generate control thrust vector redirecting propeller compliance magnetic coupling therefore achieve thrust vectoring auvs paper new design rmct presented new prototype uses flat geometry magnetic coupling better auv full integrability new design provides additional advantages regard predecessor spherical rmct namely construction simplicity better torque transmission first characteristic derived flat shapes makes easier manufacture cubic magnets isolate planar air gap rotors second characteristic due fact parts magnetic coupling store magnets increasing maximal transmitted torque paper proposes thruster dynamics model magnetic coupling model shows use dynamic parameter identification method based algorithms used robotic manipulators validity dynamicmodel identified parameters analyzed means experimental tests
falling significantly affects quality life morbidity mortality among older adults sought evaluate prospective association sedentary time physical activity falling among post menopausal women aged years recruited women health initiative observational study clinical centers across united states baseline change following evaluated year year baseline recreational physical activity met sitting sleeping min day lean body mass dual energy ray absorptiometry subset falls per year assessed annually self report questionnaire dichotomized falls year logistic regression models adjusted demographics body mass index fall history tobacco alcohol use medical conditions medications higher baseline activity associated greater risk falling trend met increased falling trend adding lean body mass models attenuated relationships physically active lifestyles increased falling among post menopausal women additional fall prevention strategies balance resistance training evaluated assist post menopausal women reaching maintaining levels aerobic activity known prevent manage several chronic diseases elsevier inc rights reserved
automotive materials core course master engineering international automotive engineering program course content focuses niche areas component design including alternative materials topic presented relation particular application formal lectures combined materials manufacturing selection case studies properties materials discussed context particular applications present case study focuses materials process selection automotive application particular vehicle roof rack students working groups chose different vehicles equipped different types roof racks use computer based materials process selection methodology demonstrated experiences students discussed
novel strategy developed prepare double responsive smart upconversion fluorescence material highly specific enrichment sensing glycoprotein novel double responsive smart sensing material synthesized choosing horse radish peroxidase hrp modal protein grapheme oxide support material upconversion nanoparticles ucnps fluorescence signal reporter isopropyl acrylamide nipaam vinylphenylboronic acid vpba functional monomers structure component smart sensing material investigated transmission electron microscopy tem scanning electron microscopy sem ray photoelectron spectroscopic xps fourier transform infrared ftir respectively results illustrated smart sensing material prepared successfully recognition characterizations smart sensing material evaluated results showed fluorescence intensity smart sensing material reduced gradually concentration protein increased smart sensing material showed selective recognition hrp among proteins furthermore recognition ability smart sensing material glycoprotein regulated controlling value temperature therefore strategy opens new way construct smart material detection glycoprotein elsevier rights reserved
one successfully commercialized distributed energy resources long term effects microturbines mts distribution network fully investigated due complex thermo fluid mechanical energy conversion processes complicated fact parameter internal data mts always available electric utility due different ownerships confidentiality concerns address issue general modeling approach mts proposed paper allows long term simulation distribution network multiple mts first feasibility deriving simplified model long term dynamic analysis distribution network discussed based physical understanding dynamic processes occurred within mts three stage identification method developed order obtain piecewise model predict electro mechanical system behaviors saturation next assisted electric power flow calculation tool fast simulation methodology proposed evaluate long term impact multiple mts distribution network finally model verified using capstone micro turbine experiments applied dynamic simulation modified ieee node test feeder promising results elsevier ltd rights reserved
study objectives examine imaging modality used cases essure failures determine cause unintended pregnancies noncompliance follow recommendations misinterpretation imaging test device failure design retrospective single center interventional cohort canadian task force classification setting tertiary level hospital patients women essure placement subsequent pregnancy interventions coding data regina general hospital examined pregnancy occurring essure procedure hospital charts reviewed data collection separate imaging database established time frame reviewed determine imaging modality used case transvaginal ultrasound tvu hysterosalpingogram hsg none results imaging study reviewed cause failure determined measurements main results twenty four pregnancies women identified essure procedures january march vitro fertilization pregnancies pregnancies woman instructed rely devices incomplete placement noted time procedure therefore unintended pregnancies occurred total procedures performed examination imaging studies revealed due patient noncompliance either early cessation backup contraception failure confirmatory imaging due misinterpretation imaging tests hsg tvu device failure reveals cumulative failure rate years device related conclusion essure sterilization effective means permanent contraception device failure rate unintended pregnancies essure procedure result failure comply follow recommendations strategies improve compliance emphasized aagl rights reserved
paper explores continuity change american catholic hierarchy promotion later reliance religious freedom analysis spanning years first traces pressures reform created declaration years ago demonstrating american bishops crucial actors declaration existence passage case strong legitimacy pressures roman catholic leaders predominantly protestant country paper turns summary birth control mandate affordable care act created pressures legitimacy american catholic hierarchy pressures articulated terms critiques hypocrisy demonstrates although specific critique changed accusations hypocrisy remain central discussions catholic church stance birth control mandate affordable care act
osteoporosis important cause vertebral fractures increased risk osteoporosis nursing home residents men osteoporosis osteoporotic fractures diagnosed receive treatment study aim determine osteoporosis silent vertebral fracture prevalence male nursing home residents corum turkey cross sectional study included groups patients male nursing home residents nursing home group mean age years men living homes control group mean age years bone mineral densitometry performed subjects results evaluated according world health organization criteria vertebral deformity evaluated using spinal deformity index fracture risk calculated using fracture risk assessment tool participants serum calcium phosphorus vitamin parathyroid hormone alkaline phosphates levels measured medical histories recorded osteoporosis detected men residing nursing homes men living homes silent vertebral fracture present patients older years vertebral fracture rate higher nursing home residents men living homes nursing home group control group patients aware fractures results demonstrated male nursing home residents higher risk osteoporosis vertebral fractures compared men living homes
paper describe fast algorithm creates wavelet tree sequence symbols show wavelet tree constructed log sigma root logn time number symbols alphabet size elsevier rights reserved
examination age sex gender sex gender hiv vaccine preparedness studies contribute understanding demographic variables preparation actual hiv vaccine trials descriptive review age sex gender sex gender examined relation willingness participate wtp retention hiv vaccine trial twenty five articles retrieved organization economic operation development oecd countries articles retrieved non oecd countries studies involved mainly white msm older men likely wtp hypothetical hiv vaccine trial likely retained younger men oecd studies sex gender associated wtp hypothetical hiv vaccine trial females likely retained studies largely age associated wtp non oecd countries results sex gender variable relationship adolescent adult wtp hypothetical hiv vaccine trials south africa appear modified high school student status addition studies discordant couples context hiv vaccine preparedness could conducted examine gender roles inequalities preparation hiv vaccine trials
magnetorheological fluid mrf class smart material whose acoustic properties varied rapidly reversibly applied magnetic field mrf proposed actively sound barriers acoustical metamaterial paper presents theoretical model study acoustic propagation mrf fields based biot stoll model model considers coupling interaction ferro particle base fluid paper investigated acoustic velocity attenuation commercial mrf dependence different parameters carrier fluid viscosity permeability intensity magnetic field calculated results show attenuation increased small field strengths independent field strength magnetization begins saturate elsevier ltd rights reserved
background purpose new zealand developed geographically isolated country south pacific population million genetic diagnosis standard care patients primary immunodeficiency disorders pids methods since offered comprehensive genetic testing service pids immune related disorders published sequence present results program first decade results undertook testing index cases carriers time three common test requests linked lymphoproliferative xlp tumour necrosis factor receptor associated periodic syndrome traps haemophagocytic lymphohistiocytosis hlh suspected xlp cases positive diagnoses established patients contrast genetic defects patients suspected linked agammaglobulinemia xla confirmed xla patients initially identified absence cells overall positive diagnoses made tests requested diagnostic rate lowest several conditions locus heterogeneity conclusions thorough clinical characterisation patients assist prioritising genes tested clinician driven customised comprehensive genetic service worked effectively new zealand next generation sequencing play increasing role disorders locus heterogeneity
cases reported deformed geotextile reinforced soil walls cold regions deformation likely caused frost heavein backfill soil reinforced soil walls prevent deformation caused frost heave hokkaido regional development bureau ministry land infrastructure transport tourism established specific construction techniques however preventive measures specified geotextile reinforced soil wallsalready service toward proposing countermeasures frost heave deformation full scale tests conducted results demonstrated application insulating materials outer surface geotextile reinforced soil walls helps control frostheave deformation
recent interest improving pedagogical approaches science technology engineering mathematics stem fields stimulated research many universities several educational methodologies reviewed context manufacturing lens sustainability found need identify understand stem educational challenges assess usefulness existing methodologies using case based analyses particular research aims support student learning manufacturing engineering real time process evaluations pedagogical framework presented assist engineering educators developing learning modules support goal framework encompasses four steps define learning outcomes create instructional resources create active learning resources create summative assessment mechanism framework emphasizes engagement manufacturing engineering students psychomotor learning remains challenge due high cost instructional laboratories framework applied develop participatory pedagogy manufacturing courses use computer numerical control manufacturing operations real time monitoring visualization data analysis machine energy use framework demonstrated upper level undergraduate graduate manufacturing engineering courses two universities computer aided design manufacturing oregon state university precision manufacturing university california berkeley found framework effectively support learning module development manufacturing engineering education
paper aims develop multi criteria decision analysis mcda tool rainwater harvesting rwh university campus bogota colombia specific type mcda research proposes known cride multi criteria decision support tool allows study various methods rwh order account uncertainties variability expert opinions imprecision stemming different criteria required designed tool incorporate electre monte carlo method case study apply methodology evaluates performance six rwh scenarios six input scenarios emerged ideal one wherein rainwater throughout campus successfully harvested treated potable reality sets five scenarios varying degrees deviance ideal one terms water quantity quality regard collection treatment used sustainable urban drainage systems suds evaluation scenarios outline eight criteria include hydraulic performance compatibility university master plan financial aspects research concludes cride means support decision making process generates complete view possible solutions addition ranking solutions cride based approach allows proposal methodology evaluates relevance established criteria set using robustness redundancy sensitivity
background hospice care appropriate patient longer benefits curative treatment limited life expectancy patients may suffer type life limiting illness including end stage cancer end stage heart disease end stage renal failure aids alzheimer disease among illnesses patients managed pain symptoms home hospice care manages patients comfort home enabling patients spend last days dignity good quality life objective describe home hospice patients hca hospice care hhc singapore description home care patients terms sociodemographic profile diagnosis admission reviewed electronic medical records patients admitted hhc results patients multiple admissions hhc home hospice identified electronic medical records emr january december selected patient first admission hhc home hospice analysis patients entire samples males married chinese patients died home referred public hospitals primary caregivers children mean age patients years among cancer patients admitted hhc home hospice lung cancer common principal diagnosis admission followed colorectal liver cancers among noncancer patients renal failure common diagnosis among male patients admitted hhc home hospice lung cancer common diagnosis followed liver cancer colorectal cancer end stage renal failure female patients lung cancer common diagnosis followed breast cancer colorectal cancer end stage renal failure ten year trends sociodemographic profile diagnosis admission analyzed determine home hospice services utilization needs home care patients conclusion increasing emphasis encourage aging dying community attention given building home hospice industry capacity capability important understand profile patients utilizing home hospice services also helps plan develop similar services parts world
introduction opioid dependence relapse complex multidimensional problem lack spiritual well major concern opioid addicts aim study conducted determine spiritual well factors associated relapse materials methods cross sectional study conducted april september according purposive sampling eligible addicted patients enrolled study patients least attempt detoxification past six months referred outpatient detoxification clinic shahrekord southwest iran completed paloutzian ellison spiritual well scale researcher developed questionnaire consisting demographic characteristics questions associated factors relapse administered data analysed version spss inc chicago using one way anova pearson correlation test chi square friedman test student test results important factors associated opioid dependence relapse consist relation addict friend unemployment living expenses family conflicts somatic pain present study patients never experienced relapse mean relapse rest participants times furthermore addicted patients relapse significantly lower scores spiritual well subscales compared non relapse patients conclusion findings present study indicate necessity paying attention spiritual well family economical personal occupational factors crucial factors opiate addiction relapse
paper describes application vivo systems response profiling cns drug discovery process referred integrative screening process biological response profile treated array used major outcome selection candidate drugs dose response data including vivo brain monoaminergic biomarkers behavioral descriptors systematically collected analyzed principal component analysis pca partial least squares pls regression yielding multivariate characterization across compounds approach exemplified assessing new class cns active compounds dopidines compared monoamine modulating compounds including antipsychotics antidepressants procognitive agents dopidines display distinct phenotypic profile prompted extensive preclinical clinical investigations summary vivo profiles cns compounds mapped based dose response studies rat applying systematic standardized work flow database vivo systems response profiles compiled enabling comparisons classification creates framework translational mapping crucial component cns drug discovery
date one proven hydrocarbon accumulation ashmore platform bonaparte basin australia hydrocarbon charge remaining key exploration risk south neighbouring browse basin proven lateral migration generated hydrocarbons basin bounding highs evidenced seeps located yampi shelf paper describes findings natural seeps study carried establish migrating subsurface hydrocarbons reach southern flanks ashmore platform basement high integrated study combined remote sensing geophysical acoustic photographic geochemical techniques identified three areas seepage one area characteristic persistent seepage two areas interpreted episodic leakage geochemical data collected samples one sites demonstrates presence thermogenic liquid hydrocarbons isotopic compositions falling within range values exhibited oils sourced lower cretaceous echuca shoals formation identification active natural seepage along southern flank ashmore platform provides evidence hydrocarbons generated within caswell sub basin able laterally migrate onto flanks ashmore platform structural high findings reduce charge risk ashmore platform regional exploration risks northern browse basin elsevier ltd rights reserved
research economic factors affect attitudes toward immigration often focuses labor market effects concluding workers skill levels predict opposition low versus highly skilled immigration economic self interest shape policy attitudes conduct new survey measure beliefs range economic political cultural consequences immigration economic self interest broadened include concerns fiscal burdens created immigration beliefs economic effects strongly correlate immigration attitudes explain significant share difference support highly versus low skilled immigration although cultural factors important results suggest previous work underestimates importance economic self interest source immigration policy preferences attitudes generally
within work analysis selected arterial system segments performed regarding various hematocrit values properties arteries transformed electrical quantities using electromechanical analogy theory two port electrical circuits used analysis selected arterial segments characteristic voltage current transfers calculated order determine atrial properties function frequency various hematocrit values work deals model blood viscosity assuming non newtonian flow combines newtonian blood flow characteristic used arterial system model impact different hematocrit values selected arterial segments evaluated
fungal infections rare compared bacterial infections increase critical care units diagnosis difficult resulting increased mortality lmmunocompromised patients higher risk fungal infections including organ transplant oncology hiv aids patients fatigue fever common symptoms require critical care nurses remain vigilant assessment identify risk patients promote use timely cultures appropriate treatments fungal infections critical care nurses contribute decreasing risk fungal infections controlling glucose levels decreasing use invasive lines preventing unnecessary antibiotic use
einstein aether theory violating lorentz invariance permits super luminal communications universal horizon trap excitations traveling arbitrarily high velocities better understand nature universal horizons first modify ray tracing method use study surface gravity charged einstein aether black hole spacetime instead previous result cropp results show surface gravity universal horizon dependent specific dispersion relation kuh denotes power leading term superluminal dispersion relation characterizing different species particles associated hawking temperatures also different findings coincide derived tunneling method provide full understanding black hole thermodynamics lorentz violating theories
joint service involving several clouds emerging form cloud computing hybrid clouds schedulers within cloud must self adapt job arrival processes workload also mutually adapt scheduling polices schedulers however combinatorial optimization problem scheduling challenged adaptation dynamics uncertain behaviors peers article studies collaboration among benevolent clouds cooperative nature willing accept jobs clouds take advantage machine learning propose distributed scheduling mechanism learn knowledge job model resource performance others policies without explicit modeling prediction machine learning guides scheduling decisions based experiences examine performance approach conducted simulation using job workload log san diego supercomputer center test bed based agent based systems swarm results validate approach much shorter mean response time typical dynamic scheduling algorithms opportunistic load balancing minimum execution time minimum completion time switching algorithm percent best better collaboration hybrid cloud achieved full adaptation
forecasting stock returns risk represents one important concerns market decision makers although many studies examined single classifiers stock returns risk methods fusion methods recently emerged require study area main aim paper propose fusion model based use multiple diverse base classifiers operate common input meta classifier learns base classifiers outputs obtain precise stock return risk predictions set diversity methods including bagging boosting ada boost applied create diversity classifier combinations moreover number procedure selecting base classifiers fusion schemes determined using methodology based dataset clustering candidate classifiers accuracy results demonstrate bagging exhibited superior performance within fusion scheme could achieve maximum accuracy decision tree lad tree rep tree return prediction accuracy tree dtnb lad tree risk prediction feature selection part wrapper algorithm developed compared fusion model paper seeks help researcher select best individual classifiers fuse proper scheme stock market prediction illustrate approach apply tehran stock exchange tse data period elsevier rights reserved
pilot study compared sedentary behavior children autism asd typically developing peers evaluated influence social contexts within free play organized activity settings children asd inclusive summer camp participants asd matched peers age gender modified osrac utilized assess social context setting differ diagnosis asd setting social contexts children asd spent significantly time within social contexts compared solitary contexts asd related social deficits may facilitate children asd summer camp social contexts compared solitary context
background although aromatase inhibitors proven effective treatment hormone receptor positive breast cancer postmenopausal women aromatase inhibitorinduced arthralgia aia adverse event associated low compliance treatment aim literature study assess prevalence aia provide overview significant predictors development aia methods systematic review conducted using pubmed cochrane library web science meta analysis performed heterogeneity investigated moderator analyses meta analysis repeated studies considered best evidence studies average score strobe checklist results twenty one studies participants included prevalence rates ranged meta analysis resulted pooled estimate high heterogeneity moderator analysis showed differences regarding heterogeneity predictors development aia included body mass index taxane based chemotherapy stage iii cancer duration menopause years years indicates predictor lower risk aia discussion despite established benefits important portion patients experiences aia research needed investigate efficacy treatments exercise therapy aia
sexuality integral part overall health impact neurological diseases sexual function still receives little attention aim case control study compare frequencies characteristics sexual dysfunction women stable relapsing remitting multiple sclerosis migraine sexually active women aged years recruited headache outpatient clinics university hospital asked complete questionnaires sexual function using multiple sclerosis intimacy sexuality questionnaire msisq adapted patients migraine depression using beck depression inventory bdi quality life using short form questionnaire least one symptom sexual dysfunction almost always always present patients patients migraine msisq total score differ two groups respectively sexual dysfunction categorized primary secondary tertiary patients migraine patients respectively depressive symptoms common women sexual dysfunction without migraine showed decreasing quality life increasing msisq sum scores mental subscale physical subscale sexual dysfunction major problem women women migraine strongly associated comorbid depression impaired quality life thus categorizing sexuality done msisq limited complex biopsychosocial interactions
thermal hydraulics analysis nuclear reactor components lwrs light water reactors reactor vessel steam generator containment multi dimensional two phase flow code named cupid developed cupid code pursues capability multi physics multi scale thermal hydraulics analysis present study multi scale simulation performed coupling system scale code mars coupled code assessed visualize flow behavior steam generator advanced power reactor apr primary side steam generator remaining reactor coolant system rcs modeled mars secondary side cupid secondary side simulation cupid part porous media approach adopted two fluid model conductor model simplify complicated geometry steam generator order obtain porosity given computing cell special algorithm employed directly calculate volume ratio mapping cad file onto grid system besides proper constitutive relationships tubes considered treat complex thermo hydraulic phenomena shell side steam generator set constitutive models available literature two phase flow map interfacial heat mass transfer interfacial drag wall friction wall heating heat partitioning flows tube bundles applied close numerical model paper presents description coupling method porous media approach simplify steam generator simulation results using coupled code elsevier ltd rights reserved
expansion electric vehicle market bring changes type environmental impact generated transport sector partially associated introduction new technologies energy storage powertrains including electric motors technology play critical role assure optimal performance key components innovative materials integrated current motor designs case permanent magnets commonly made rare earth elements history ecological concerns related mining goal paper study novel traction motors assess influence components environmental performance motor electric vehicle study life cycle assessment lca performed including manufacturing use end life stages traction electric motor applications comparison presented rare earth magnets replaced ferrite magnets several efficiency scenarios average european conditions considered framing modeling functional unit driven vehicle used twelve impact categories selected present potential environmental impact motors energy consumption use stage identified hotspot responsible important share impact amount energy consumed highly dependent efficiencies powertrain improving efficiency regarded crucial decreasing environmental damage produced motor use rare earth magnets manufacturing represent significant share impact take total mass components including laminations housing windings instead recognized significant mangets mainly climate change toxicity humans soil water bodies well metal depletion use alternative materials rare earth magnets contribute reduction potential impact long overall efficiency motor remains increases based study results concluded environmental performance traction motor closely tight efficiency selection materials design focus preserving improving efficiency motor materials low environmental impact production
field nano technology first time microcontroller controlled high voltage power supply electrospinning nanofiber generator designed main purpose microcontroller driven nanofiber generator design reduce unit cost increase precision efficiency using technology varying collector unit ultra thin aligned non aligned nanofibers engendered high voltage power supply takes low voltage input generates high voltage low current output mandatory stimulate nanofiber emphasis paper elaborate details hardware software design nanofiber generation technique control strategy stepper motor plunger movement design proficiently used designing high accuracy nanofiber generators produce ultrathin nanofibers nanofibers predominantly used field nano medicine agriculture textile industry
remote sensing image data vast requires compression low complexity algorithm space borne equipment binary tree coding adaptive scanning order btca effective algorithm mission however large scale remote sensing images btca requires lot memory provide random access property paper propose new coding method based btca optimize truncation wavelet image first divided several blocks encoded individually btca according property btca select valid truncation points block carefully optimize ratio rate distortion higher compression ratio lower memory requirement random access property attained without entropy coding proposed method simple fast suitable space borne equipment experiments conducted three remote sensing image sets results show significantly improve psnr ssim vif well subjective visual experience elsevier inc rights reserved
backgroundthe role race modifying association among diabetes obesity prostate cancer cap progression well studied evaluated diabetes obesity association time cap progression white americans whites black americans blacks methodsour study sample consisted white black research participants health care access cap treatment north carolina hcap cohort association self reported diabetes obesity cap progression mean follow time approximately years assessed using cox proportional hazards modeling adjustment potential confounders stratum specific hazard ratio estimates whites blacks evaluated resultsself reported diabetes associated cap progression cohort whole among racially defined groups whites blacks obesity positively associated cap progression among whites models including excluding diabetes covariate association observed obesity cap progression blacks cohort whole conclusionsself reported diabetes associated cap progression hcap obesity associated cap progression among white research participants wiley periodicals inc
many real world applications like video demand vod web servers require prompt responses access requests however explosive increase data volume emerging faster disks higher power requirements energy consumption disk based storage systems become salient issue achieve energy conservation prompt responses simultaneously paper propose novel energy saving data placement strategy called striping based energy aware sea applied raid structured storage systems noticeably save energy providing quick responses implement two sea powered raid based data placement algorithms sea sea incorporating sea strategy raid raid respectively extensive experimental results demonstrate compared three well known data placement algorithms greedy sea sea reduce mean response time average least saving energy average less respectively
generalized coupled line pass phasers based cascaded sections ccss cascaded coupled lines ccls hybrid cascaded coupled transmission line sections presented demonstrated using analytical full wave experimental results shown commensurate coupled line sections ccl phasers exhibit group delay peaks per coupled line section harmonic frequency band contrast ccs configuration exhibits one peak within band also shown given maximum achievable coupling coefficient configuration provides largest group delay swing wave interference analysis finally applied various coupled line phasers explaining unique group delay characteristics based physical wave propagation mechanisms
software development organizations rely capability maturity model integration cmmi assess improve processes realized agile approaches provide improvements well cmmi agile methods work well together exploit synergies potential improve dramatically business performance major question realize integration two seemingly different approaches earlier work conducted field study within six companies companies worked agile methods years egyptian software engineering competence center secc regional cmmi appraisal center assessed study mainly conducted enhance empirical understanding research field additionally showed companies usually use agile good way helps covering cmmi specific practices paper present new approach mapping cmmi scrum method mapping analyzed enhanced applied companies putting considerations previous efforts worked context older version cmmi research using latest cmmi version research shows mapping approach resulted satisfaction achieved partial satisfaction cmmi specific practices resembles enhancement satisfaction improvement partial satisfaction previous related research effort already targeting latest cmmi version
simulation light flux density distribution receiver plays important role energy estimation design optimization heliostat field focusing strategy central receiver system crs however simulation time consuming procedure paper propose fast simulation method fully exploits tremendous rendering parallel computing capacities contemporary graphics processing units gpus first auxiliary spatial data structure employed organize heliostats field parallel light beam traversal algorithm designed performed gpu determine shadowing blocking heliostats reference heliostat flux spot reflected heliostat receiver computed using hflcal model accumulated final flux density distribution computing stage accumulation stage accomplished via gpu rendering pipeline proposed method verified taking power plant example method considers shadowing blocking effects simulation results consistent official report due high efficiency proposed method potential applications crs design optimization elsevier ltd rights reserved
intermittent sand filtration isf efficient system treatment greywater however high quality effluent simple set contrast high failure rate due clogging surface layers efficacy several polypropylene non woven geotextiles apparent opening size used primary treatment filters remove suspended particles domestic greywater effects pretreatment performance fine small media size isfs examined results showed geotextile achieved suspended solids removal rates chemical oxygen demand cod although portion larger removed higher rates particles smaller nominal pore size filter also captured geotextile used pretreatment resulted improvement lifetime isfs experimental run days vertical profile volatile organic matter isfs evaluated end experiment showed clear reduction accumulation organic material top layer isfs effectively avoiding early failure accumulation solids
myeloproliferative neoplasms mpns common underlying prothrombotic disorder found patients splanchnic vein thrombosis svt clinical risk factors mpn associated svts include younger age female sex concomitant hypercoagulable disorders jak mutation risk factors distinct associated arterial deep venous thrombosis dvt mpn patients suggesting disparate disease mechanisms pathophysiology svt thought derive local interactions activated blood cells unique splanchnic endothelial environment mutations commonly found mpns including calr mpl rare mpn associated svt purpose article review clinical molecular risk factors mpn associated svt particular focus possible mechanisms svt formation mpn patients
purpose study find analyze factors relating community empowerment ability health problem solving formulate community empowerment model study used combined quantitative qualitative methods survey research path analysis used quantitative method case study used qualitative method study conducted villages karanganyar district central java province indonesia research resulted social capital community participation related ability health problem solving community empowerment model ability health problem solving consisted input process output factors input factors consisted internal external factors internal factors included education level knowledge awareness leadership economic status social capital community participation local resource village community discussion external factors included access information role health workers facilitators village sub district districts governments fund support meanwhile process involved efficiently resource use utilization within community facilitation output community forcefulness ability health problem solving
kinesio taping widely used treatment sports injuries various neuro musculoskeletal disorders however considered selectively effective targeted tissues mechanical effects quantified objectively ascribed continuity muscular connective tissues mechanical loading imposed widespread heterogeneous effects aim characterize mechanical effects objectively test hypotheses causes acutely local deformations necessarily agreement tape adhering direction limited directly targeted tissues high resolution magnetic resonance image sets acquired healthy human subjects prior acutely application skin along tibialis anterior hip knee ankle angles kept constant demons image registration algorithm used calculate local tissue deformations within lower leg vivo mean peak tissue strains significantly higher strain artifacts region part shows local deformations agreement tape adhering direction whereas superficial skin rest regions show deformations length change directions non targeted tissues also show sizable heterogeneous deformations smaller amplitudes inter subject variability notable magnetic resonance imaging analyses allow detailed assessment local tissue deformation occurring acutely application findings confirm hypotheses characterize affects underlying tissues immediately targeted distant allows revealing mechanisms affect clinical outcomes objectively elsevier ltd rights reserved
paper deals design charge pump circuit analyzing current mismatch problem charge sharing problem eliminated using transistors enhancing matching characteristics cascode type current mirror circuit used design provides technique value matched way time mismatch signals proposed design added advantage low power consumption simulations done power supply
study aims understand mainly qualitatively long term role human impact avulsion processes development fluvial mega fans semi arid environments paper refer human impact direct influences actions river hydraulics flow regulation flow diversion channel engineering five case studies drawn khuzestan plains southwest iran analysed setup triggering conditions specific avulsions occurred past timescale millennia identified role human interference causation analysis based integration historical archaeological geomorphological geological data study demonstrate avulsions khuzestan plains result long term complex interplay multiple human induced natural causes similar ways human induced actions may play important roles different phases avulsion development success avulsion post triggering phase may defined human induced setup causes well morphodynamic processes suggest present day flood events may partly inherited long term human alterations natural processes finding could implications fluvial system distributive fluvial systems deltas avulsion plays major role development research tends emphasize natural mechanisms copyright john wiley sons ltd
article explores socially withdrawn young finnish people internet forum identify japanese hikikomori phenomenon aim overcome dualism sociology psychology found earlier research referring pierre bourdieu provides insights individual choices constructed accordance wider social settings focus individual level everyday choices suggest psychological factors anxiety depression seen properties social relations rather individual states mind young adults unequal access valued resources scrutinise young people specific reasoning related social psychological factors contingent life events influence choice withdraw experience inadequacy feeling failure lack self efficacy common experiences data indicates young adults identify hikikomori phenomenon find external society demanding consider lacking resources education social networks personality type see valued society essential survival also feel control life events may mean receive little help everyday lives
background intervention effects observed efficacy trials rarely replicated interventions broadly disseminated underscoring need information factors influencing real life implementation program impact using data ongoing national implementation evidence based hiv prevention program focus youth caribbean foyc bahamas study examines factors influencing teachers patterns implementation impact teachers initial implementation foyc subsequent delivery booster sessions students outcomes methods data collected government elementary middle schools involving grade grade grade teachers students initially grade followed years student outcomes include hiv aids knowledge reproductive health skills self efficacy intention use protection data teachers includes implementation modification curriculum attitudes towards prevention program comfort level curriculum attendance training workshops structural equation modeling mixed effect modeling analyses applied examine impact teachers implementation results teachers attitudes towards comfort intervention curriculum attendance curriculum training workshop direct effect teachers patterns implementation direct effect student outcomes teachers attitudes direct positive effect student outcomes teachers training interactive teaching methods longer duration teachers positively associated teachers comfort curriculum high quality implementation grade significantly related student outcomes grades post implementation level implementation booster sessions grades likewise significantly related subsequent student outcomes grades conclusions high quality initial implementation prevention program significantly related better program outcomes poor subsequent delivery booster sessions undermine positive effects initial implementation strong subsequent delivery booster sessions partially overcome poor initial implementation
power generation business unit westinghouse electric corporation manufactures electric generators commonly used power generation generators require electrically insulative bracing structure support stator coil armature windings end machine several large circular cross ply composite rings used support stator coil winding adding stiffness structure prevent excessive deflections stator coils resulting peak electromagnetic loads occur electrical transients concern regarding achieved physical properties cross ply wound composite rings due limited processing capabilities process variation support ring strength modulus properties critical performance westinghouse performed testing flexural strength flexural modulus shear strength shear modulus various temperatures determine mechanical properties manufactured composite support rings discussions measured properties relationship composite material design theory manufacturing parameters provided
paper presents novel list based scheduling algorithm called improved predict earliest finish time static task scheduling heterogeneous computing environment algorithm calculates task priority pessimistic cost table implements feature prediction critical node cost table assigns best processor node least immediate successor critical node thereby effectively reducing schedule makespan without increasing algorithm time complexity experiments regarding aspects randomly generated graphs real world application graphs performed comparisons made based scheduling length ratio robustness frequency best result results demonstrate improved predict earliest finish time algorithm outperforms predict earliest finish time heterogeneous earliest finish time algorithms terms schedule length ratio frequency best result robustness maintaining time complexity
short form health survey popular health related quality life hrqol tool however studies assessed psychometric properties patients spondyloarthritis spa therefore aimed assess reliability validity patients spa singapore cross sectional data registry spa patients recruited dedicated tertiary referral clinic singapore used analyses guided consensus based standards selection health measurement instruments framework internal consistency reliability assessed using cronbach alpha construct validity assessed priori hypotheses correlations eight subscales two summary scores health outcomes known group construct validity assessed comparison means subscales summary scores spa patients general population singapore using student tests among patients males median range age chinese scales showed high internal consistency ranging convergent construct validity supported shown fulfillment hypotheses divergent construct validity supported mcs associated pga pain haq known group construct validity showed spa patients lower scores compared general population study supports valid reliable measure hrqol use patients spa single time point
people derive considerable amounts information minimal nonverbal cues apart characteristics typically regarded obvious encountering another person age race sex perceivers identify many qualities person typically rather subtle one feature sexual orientation review literature documenting accurate perception sexual orientation nonverbal cues related one adornment acoustics actions appearance addition chronicling studies demonstrated people express extract sexual orientation domains discuss basic cognitive perceptual processes support judgments including cues sexual orientation manifest behavioral clothing choices structural facial morphology signals finally attend boundary conditions accurate perception sexual orientation states traits group memberships moderate individuals ability reliably decipher others sexual orientation
purpose experimentally test whether chronic sleep restriction common among adolescents causally related poor learning inattentive behaviors diminished arousal classroom like situation methods sixteen healthy adolescents underwent sleep manipulation included counterbalanced order five consecutive nights sleep deprivation hours bed versus five nights healthy sleep duration hours bed end condition participants viewed educational films took related quizzes simulated classroom eight participants also underwent video electroencephalography monitoring assess levels inattentive behaviors arousal respectively results compared healthy sleep condition sleep deprived participants lower quiz scores inattentive behaviors lower arousal conclusions pilot data complement previous correlational reports showing chronic sleep restriction adolescence cause inattention diminished learning lowered arousal simulated classroom society adolescent health medicine rights reserved
gene associated retinoid interferon induced mortality grim targets multiple signaling pathways involved cell death growth however role grim pathogenesis hepatitis virus infections remains unexplored investigated restrictive effects grim replication hepatitis virus hcv found grim protein levels reduced hcv infected huh cells huh cells harboring hcv replicons moreover ectopically expressed grim caused reduction intracellular viral rna levels secreted viruses hcvcc infected cell cultures restrictive effect hcv replication restored treatment sirna grim interestingly grim overexpression alter level phosphorylated stat subcellular distribution strikingly forced expression grim attenuated increase intracellular lipid droplets oleic acid treatment hcvcc infection grim overexpression abrogated fatty acid induced upregulation sterol regulatory element binding transcription factor srebp resulting attenuated expression target genes fatty acid synthase fas acetyl coa carboxylase acc treatment overexpression srebp grim expressing hcvcc infected cells restored hcv replication results suggest grim interferes hcv replication attenuating intracellular lipid accumulation therefore anti viral host factor could promising target hcv treatment
background specific ige sige antibody detection using siemens immulite gallergytm gallergy assay sufficiently examined diagnosis food allergy aim study evaluate utility measuring sige levels using gallergy assay diagnose allergic reactions egg milk wheat methods retrospective study conducted patients diagnosed suspected allergies egg milk wheat patients divided two groups according clinical reactivity allergens based oral food challenge outcomes convincing histories immediate reaction causative food sige levels measured using gallergy immunocap predicted probability curves estimated using logistic regression analysis results analyzed patients ages egg milk wheat sige levels determined using gallergy correlated immunocap classifying patients symptomatic egg milk wheat gallergy sige levels significantly higher symptomatic asymptomatic patients predictive probability positive food allergy significantly increased correlated increased sige levels cut offs allergic reaction predictive probability determined gallergy probability curves different immunocap conclusions measurements sige egg milk wheat determined gallergy may used tool facilitate diagnosis food allergy subjects suspected food allergies however probability curves applied interchangeably different assays copyright japanese society allergology production hosting elsevier
objective study preliminary identification basic groups micro organisms cross sectional profile geotextile filters septic tank effluent ste treatment relations technological conditions reactors textile filters treating wastewater investigated semi technical scale filters vertically situated ste filtered hydrostatic pressure wastewater surface height filters made four layers non woven geotextile thickness various groups organisms observed abundant group comprised free swimming crawling ciliates less abundant stalked ciliates least numerous nematodes individual counts groups micro organisms investigated study variable according time space high abundance opercularia commonly observed genus stalked ciliates related high efficiency wastewater treatment dissolved oxygen concentration numbers free swimming crawling ciliates tendency decrease relation depth filter cross sectional profile variability counts particular groups organisms could related local stress conditions correlation identified organism count total mass concentration cross sectional filter profile found
new sensor placement problem formulated cover two objectives assuring quality water delivered consumers detection contamination event earliest minimize consequences maximization demand coverage time constrained detection likelihood pressure deficient networks network may become pressure deficient owing continued use water distribution network beyond design life two objectives combined using weights genetic algorithm used obtain optimum sensor locations methodology applied pressure deficient network dharampeth zone nagpur city india pressure dependent analysis carried using watergem simulate system hydraulics performance objectives evaluated considering availability flows nodes velocity flow pipes pressure deficient conditions comparison optimal sensor network design carried obtained demand dependent analysis
thyroid hormones critical early neurodevelopment studies examined whether neonatal levels influence risk autism spectrum disorder asd study linked california neonatal screening data live birth department developmental services records examine newborn levels relation asd thyroxine thyroid stimulating hormone tsh levels measured newborn bloodspots part routine screening respectively mean levels tsh compared asd cases non cases four hundred forty seven thousand fifty nine screened singleton births examined including asd cases binomial regression using categories tsh percentiles used calculate crude adjusted risk ratios covariates included maternal child factors gestational age age blood draw significant associations found tsh levels asd crude adjusted analyses asd cases significantly lower mean levels non cases association longer significant adjusted analyses individuals lowest percentile levels however association appeared stronger certain subgroup analyses particularly among neonates blood draw birth levels become stable thus results large population based study suggest strong associations neonatal asd certain subgroups newborns lowest levels may modestly increased asd risk autism res international society autism research wiley periodicals inc autism res international society autism research wiley periodicals inc
work chemiluminescence biosensor prepared ultrasensitive determination deoxyribonucleic acid dna based adsorption recognition function core shell feo sio graphene oxide feo sio polymers dna feo sio polymers composed magnetite nanoparticles core shell polymers confirmed scanning electron microscope sem ray powder diffraction xrd fourier transform infrared ftir feo sio modified dna based principle complementary base feo sio dna introduced system selectivity sensitivity dna detection significantly improved adsorption properties feo sio dna researched adsorption equilibrium adsorption kinetic thermodynamics optimized conditions dna could assayed linear concentration range mol detection limit mol relative standard deviation rsd biosensor finally used determination dna laboratory samples recoveries ranged satisfactory results revealed potential application feo sio dna biosensor diagnosis treatment human genetic diseases elsevier rights reserved
third generation wireless systems expected provide wide area wireless internet multimedia services including multiparty conferencing based session initiation protocol sip satellite units umts constitutes promising alternative provision types multiparty conferencing services due wide area coverage properties however supporting multiparty conferencing umts challenging task due complicated signalling involved compared point point sessions also due adverse channel condition long round trip delay encountered satellite radio links paper describes end end signalling flow conferencing creation umts investigates performance satellite radio interface variations radio link control rlc parameters retransmission options overall conference creation performance also examined
cusp emergence new wave nonvolatile memory technologies projected become dominant type main memory near future key property new memory technologies asymmetric read write costs writes order magnitude higher energy higher latency lower per module bandwidth reads high cost writes motivates rethinking algorithm design towards write efficient algorithms data structures reduce number writes many popular techniques sequential distributed parallel algorithms tuned setting reads writes cost hence need revisited prior work reducing writes contended cache lines shared memory algorithms useful new technologies even writes uncontended memory costly moreover new technologies unlikely replace fastest cache memory motivating study multi level memory hierarchy comprised smaller symmetric level larger asymmetric level lower bounds need revisited light asymmetric costs talk provides background emerging memory technologies highlights progress date exciting research questions touches many open problems
software development process embedded systems getting faster faster generally incurs increase associated complexity consequence technology companies tend invest fast automatic verification mechanisms create robust systems reduce product recall rates addition development time reduction system robustness achieved cross platform frameworks favor reliable port software stacks different devices based present paper proposes simplified version framework integrated checker based satisfiability modulo theories smt known efficient smt based context bounded model checker verifying actual based applications success rate developed benchmark suite furthermore simplified version framework named operational model also evaluated using state art verifiers programs fact operational model combined different verification approaches explicit state model checking also symbolic bounded model checking experimental evaluation highlights flexibility proposed methodology first one formally verify based applications potential devise new directions software verification portable code
molecular dynamics method used simulate thermodynamic properties two binary alloys calculated energy functions including cohesive energy formation energy results display formation energy excess free energy negative values alloys belong negative system atomic interactions analyzed macroscopic microcosmic views calculated formation energy describe deviation degree actual alloy ideal melt quantitatively alloy excellent casting performance comprehensive thermodynamic performance well separated vacuum distillation noble metal greatly enriched thermodynamic properties alloy play key role vacuum distillation metallurgy due lack experimental thermodynamic data alloy difficult calculate reaction concerned alloy therefore computer simulation method becomes effective means molecular dynamics simulation widely used material field many reports defect surface property liquid structure pure metals alloys come forth however rarely used metallurgy less simulation thermodynamic properties metals alloys home abroad thermodynamic properties play key role metallurgy energy functions calculated compared available experimental ones wide temperature range paper
trastuzumab based treatment standard care patients metastatic breast cancer mbc mbc showed long term durable response progression free survival pfs years trastuzumab based therapy aim study identify clinico pathologic factors durable response trastuzumab based therapy positive mbc yonsei breast cancer mbc database identified mbc patients diagnosed among disease received trastuzumab plus taxane chemotherapy first line treatment clinico pathologic factors hormone receptor status metastatic sites reviewed evaluate durable response landmark analysis performed median follow time months months patients patients bone common metastatic site median pfs overall survival months respectively patients showed tendency toward longer pfs median months compared patients patients non visceral metastases longer median pfs visceral disease median pfs months median months landmark analysis months suggested pfs patients significantly longer patients median months among patients mbc status possible predictive biomarker durable response trastuzumab based therapy
introduction onychomycosis fungal nail infection accounts half nail diseases oral drugs market adverse effects difficult traditional topical drugs penetrate nail plate reach diseased nail bed tavaborole new drug addresses unmet needs currently available treatments tavaborole fda approved treating toenail onychomycosis shown antifungal activities yeast moulds dermatophytes areas covered objective article review efficacy pharmacokinetics pharmacodynamics safety tavaborole treatment toenail onychomycosis expert commentary tavaborole unique mechanism may good candidate use treating children fungal infections diabetic individuals treating mixed infections tavaborole may paired therapies potentially increase cure rates
marine sector produces large portion total air pollution emissions engines used must improved achieved using new eco friendly engine waste heat recovery system dual fuel engine introduced lng carriers eco friendly high thermal efficiency since uses natural gas fuel thermal efficiency could improved organic rankine cycle orc novel dual loop orc system designed engines upper orc loop recovers waste heat exhaust gas bottom orc loop recovers waste heat jacket cooling water lng cold orc loops optimized produce maximum net work output optimum simple dual loop orc pentane working fluids produces additional power output original engine output system improvement studies conducted using recuperator preheater feasibility using boil gas heat sink analyzed optimization system configuration revealed preheater recuperator pentane working fluids increase maximum net work output original engine output elsevier ltd rights reserved
background sociodemographic factors alcohol drug intake maternal health known associated adverse outcomes pregnancy women severe mental illness addition use psychotropic medication study describe demographic characteristics women hospitalized severe mental illness along use medication drugs pregnancy period methods clinical case note review women psychosis hospitalized state psychiatric hospital western australia gave birth received psychiatric treatment pregnancy period mother clinical information available case notes midwives record demographic characteristics mothers described together hospitalization pattern medication substance use pregnancy period results total mothers history severe mental illness identified gave birth mothers received psychiatric care pregnancy period one hundred thirty two taken psychotropic medication period mothers married aboriginal status living regional remote areas appeared less likely hospitalized pregnancy period older mothers diagnosis schizophrenia likely hospitalized number mothers taking psychotropic medication first trimester pregnancy reduced compared previous months decline number taking substances period significant women attempted suicide pregnancy period non suicidal self injury conclusion women demonstrate pattern decreased use psychotropic medication use period pregnancy first trimester pregnancy data highlight importance women severe mental illness receiving regular ongoing monitoring support psychiatrist pregnancy regarding level medication required well counseling regard substance use non suicidal self injury attempted suicide
triacetin glycerol triacetate obtained acetylating glycerol product biodiesel production process procedure interesting alternative follows principles green chemistry work triacetin synthesized using reactions glycerol acetic acid well glycerol acetic anhydride using homogeneous heterogeneous acid catalysis goal use product additive biodiesel produced palm oil fuel physical properties require improvement products characterized fourier transform infrared spectroscopy ftir nuclear magnetic resonance nmr gas chromatography reaction glycerol acetic anhydride effective obtaining desired product approximate selectivity triacetin triacetin added diesel fuel oil biodiesel proportions mixtures tested electrical generator test engine showed problems operation incorporating mixtures result significant consumption small reductions detected opacity changes observed emissions nox
american researchers led world developing evaluating disseminating evidence based psychiatric rehabilitation practices people serious mental illness paradoxically however usa lags behind industrialized nations providing access high quality mental health psychiatric services essay examines several evidence based practices developed usa spread practices barriers ensuring availability people could benefit services promising directions overcoming barriers factors influencing growth sustainment effective client centred practices include availability adequate stable funding committed leadership influence vested interests two strategies promoting spread sustainment well implemented evidence based practices adoption fidelity scales learning communities
new combination electrical machine two step planetary gear high torque traction applications introduced kind machine act propulsion motor working machines agricultural tractor needs generate high traction forces also higher travelling speeds technology also suits road vehicle use buses trucks detailed information electrical machine design provided machine tooth coils stator embedded permanent magnets rotor cooling arranged via gear lubrication chamber semi filled oil
purpose article seeks improve treatment outcomes slipped capital femoral epiphysis scfe outlining advances diagnosis understanding pathomechanics mechanically based classification methods review clinical experience scfe high volume centre interaction clinical experts literature review allowed current perspective articulated results scfe remains important clinical problem late diagnosis still frequent improved understanding ubiquity femoroacetabular impingement guided current classification treatment protocols conclusion scfe important clinical problem high historical rates impaired hip function childhood adulthood great opportunities exist improved outcomes following earliest possible clinical diagnosis modern imaging mechanically based classification involved hips allow optimal treatment
paper explores relationship advent birth control pill divorce rates women using pill decide whether children whether maintain attachment labor force ability may increase women autonomy making divorce feasible pill effects identified quasi experiment exploiting differences language comstock anti obscenity statutes approved late early united states empirical evidence state level data divorce rates shows sales bans oral contraceptives negative impact divorce findings robust alternative specifications controls observed women labor force participation unobserved state specific factors time varying factors state level results suggest impact women control hormonal contraception autonomy important divorce decisions
shallow flows play significant role sediment management dam reservoirs sedimentation shallow reservoirs free flow flushing operation shallow flow emerges symmetric asymmetric patterns flow domain exhibits complex three dimensional features helical flows study focuses numerical modelling velocity field shallow reservoirs varying geometries also varying bed conditions flat misshaped beds fully numerical model using finite volume method utilised reproduce flow velocity field experimentally measured surface velocity cases velocity profiles one case used validate model numerical results showed slight disturbance inflow boundary condition results steady asymmetric flow pattern reservoirs higher defined shape factor affect flow pattern reservoirs lower defined shape factor nonetheless simulated measured flow velocity fields reasonably consistent cases results used optimise design sand traps water storage facilities also optimise sediment management existing reservoirs
analysts prototyping trading strategies often reuse previously computed values full problems subproblems avoiding recomputing would increase productivity built memoization library caches function computations files avoid recomputation minimize need users think whether caching appropriate giving control speed accuracy space usage guo engler built automatic memoization library modifying python interpreter jug joblib distributed computing libraries memoization library attempts maintain ease use libraries offering higher degree control caching carried allows control space usage individual functions memoization refreshing memoization specific function accuracy checking uses faster hashing provides divide conquer approach reuse previously computed subproblems show markowitz optimization fama french singular value decomposition memoization using library greatly speeds recomputation often versus memoization versus joblib also show divide conquer memoization approach give large speedups sorting published article government work public domain usa
pamela ann davies argues closure lynemouth aluminum smelter generated adverse social justice impacts caused adoption green state policies employs argument critique green criminology promoting adverse social justice impacts reanalyze lynemouth plant closure first reanalysis illustrates various social environmental forms injustice plant generated especially adverse human nonhuman ecological health consequences second closure reassessed political economic perspective places plant closure within context global capitalist plant closures aluminum industry review notes plant closures deindustrialization developed economies common occurrence driven economic concerns environmental policies point social injustice well ecological destruction often created normal operation capitalism consequences overlooked
introduction psoriasis chronic inflammatory skin disease characterized epidermal hyperproliferation abnormal differentiation inflammatory infiltration dermis dermal microvascular expansion associated abnormal orientation dilatation capillaries biopsies psoriatic skin suggest disease dependent angiogenesis aim analyze compare immunohistochemical expression angiogenic factors vascular endothelial growth factor vegf von willebrand factor vwf skin biopsies psoriasis cases control skin samples correlate expression angiogenic factors psoriasis area severity clinical index pasi score materials methods prospective case control study conducted period months thirty two psoriasis cases thirty control skin samples included study skin biopsy specimen taken clinically diagnosed psoriasis cases receive treatment diagnosis psoriasis vulgaris confirmed micro scopic examination immunohistochemical expression vegf vwf studied results vegf expression epidermis significantly higher cases compared control skin expression significantly upregulated cases compared controls von willebrand factor expression weak cases controls significant correlation expression vegf pasi score expression pasi score observed conclusion present study significant overexpression vegf noted cases compared controls keratinocytes psoriatic skin lesions recognized source pro angiogenic cytokines namely vegf growth factors promotes angiogenesis psoriatic plaque angiogenesis plays important role genesis development psoriasis vulgaris therefore development targeted anti angiogenic therapy might beneficial chronic disabling dermatological disease
compact reflection type phaser composed quarter wavelength transmission line resonators interconnected alternating inverters proposed design method also presented validate method fourth order example designed fabricated proposed phaser shown exhibit benefits smaller size easier fabrication suppressed even order harmonics compared previously reported half wavelength phasers
confabulation often observed amnesic patients brain damage however evidence regarding relationship confabulation neuropsychological functions scarce addition previous studies proposed two possibilities relationship confabulation false memory patients confabulation likely retrieve false memories confabulations relatively independent false memories present study investigated confabulation related various cognitive functions including orientation attention frontal lobe function memory mental status false memories assessed deese roediger mcdermott drm paradigm patients organic amnesia participated confabulations evaluated using confabulation battery amnestic patients classified two groups confabulating nonconfabulating patients ncp group significantly impaired time orientation attention verbal memory compared ncp group age matched healthy controls results drm paradigm revealed significant difference false memory retrieval induced critical lures across ncp groups confabulating responses organic amnesia could part induced disturbance time consciousness attention control severe impairment verbal memories confabulation false memory could modulated different cognitive systems
background low serum testosterone low repeatedly linked worse outcomes men newly diagnosed prostate cancer low contributes outcomes unknown demonstrate exposure low causes significant changes mouse prostate prostate stem cells methods mice castrated implanted capsules achieve castrate normal sub physiological levels weeks treatment used quantify levels dihydrotestosterone dht serum prostate tissue facs used quantify percentages purported prostate stem transit amplifying cells mouse prostates prostate tissues also stained presence cells rna extracted prostate tissue specific cell populations measure changes transcript levels low treatment results despite significantly different levels dht serum dht concentrations prostate tissue different treatment groups similar low treatment resulted significant alterations expression androgen biosynthesis genes may related maintaining prostate androgen levels furthermore expression androgen regulated genes prostate similar among treatment groups demonstrating mouse prostate maintain functional levels androgens despite low serum levels low increased frequency prostate stem cells adult prostate tissue caused major transcriptional changes cells gene ontology analysis suggested low caused inflammatory responses immunofluorescent staining indicated low treatment led increased presence macrophages prostate tissue conclusions low alters signaling axis likely leads maintenance functional levels prostate androgens low also induces quantitative qualitative changes prostate stem cells appear lead inflammatory macrophage infiltration changes proposed lead aggressive phenotype cancers develop may contribute poor outcomes men low wiley periodicals inc
administration prostaglandin receptor ptger antagonist prevent pregnancy adult female monkeys blocking periovulatory events follicle without altering menstrual cyclicity general health first study demonstrate ptger antagonist serve effective non hormonal contraceptive primates requirement pge ovulation release oocyte surrounded expanded cumulus cells cumulus oocyte expansion established generation ptgs ptger null mutant mice critical role pge primate ovulation supported evidence intrafollicular injection indomethacin rhesus monkeys suppressed follicle rupture whereas injection pge indomethacin resulted ovulation first controlled ovulation protocols performed adult female rhesus monkeys analyze mrna levels genes encoding pge synthesis signaling components naturally selected pre ovulatory follicle different times ovulatory hcg stimulus pre ovulation post ovulation time point second controlled ovarian stimulation cycles utilized obtain multiple cumulus oocyte complexes cocs rhesus monkeys evaluate role pge vitro animals treatment parts per thousand yen cocs animal treatment third adult cycling female cynomolgus macaques randomly assigned group vehicle control ptger antagonist bay groups perform contraceptive trial first treatment cycle male proven fertility introduced group remained housed together duration month contraceptive trial followed post treatment reversibility trial quantitative real time pcr coc culture expansion immunofluorescence confocal microscopy enzyme immunoassay contraceptive trial ultrasonography complete blood counts serum biochemistry tests blood lipid profiles several mrnas encoding proteins involved pge synthesis metabolism signaling increase periovulatory follicle administration ovulatory hcg bolus pge signaling ptger induces cumulus cell expansion production hyaluronic acid critical events fertilization moreover chronic administration selective ptger antagonist resulted significant versus vehicle treated controls contraceptive effect without altering steroid hormone patterns menstrual cyclicity months contraceptive trial fertility recovered early month ending treatment proof concept study non human primate model investigations warranted elucidate mechanism ptger antagonist action primate ovary although ptger antagonist treatment produce obvious undesirable effects improvements mode administration well efficacy compounds necessary consider contraceptive women monitoring well improving efficacy safety female contraceptives important public health activity even though hormonal contraceptives effective women concerns remain regarding side effects long term use widespread actions steroidal products many tissues moreover women take hormones medical reasons thus development non hormonal contraceptives women warranted supported bayer healthcare pharmaceuticals eunice kennedy shriver nichd contraceptive development research center nih office director oregon national primate research center lalor foundation postdoctoral basic research fellowship mcp use leica confocal supported grant number srr authors employees bayer healthcare pharma
subtalar dislocations uncommon representing similar traumatic dislocations present two cases closed medial subtalar dislocation systematic literature review last years performed embase medline pubmed cochrane search literature written english january december keywords used subtalar peritalar subastragalar luxatio pedis sub talo dislocation dislocations articles presenting original patient data included available data regarding gender age direction affected side open closed injury accompanying fractures reduction time immobilization outcomes collected database seventy six articles included total reported cases males right foot affected often females left foot average age years range months years cause injury traffic accident fall sports injuries sprain injuries causes direction dislocation medial lateral posterior anterior open dislocation reported additional osseous injury diagnosed closed reduction unsuccessful requiring immediate open reduction overall outcomes literature good fair poor
nurturing environments within context families schools communities play important role enhancing youth behavioral choices health outcomes increasing prevalence rates obesity among youth especially among low income ethnic minorities highlight need develop effective innovative intervention approaches promote positive supportive environments across different contexts risk youth propose integration social cognitive theory family systems theory self determination theory offers useful framework understanding individual family social environmental level factors contribute development nurturing environments paper summarize evidence based randomized controlled trials integrate positive parenting motivational behavioral skills strategies different contexts including primary care home community school based settings taken together studies suggest youth parents likely benefit youth receive individual level behavioral skills family level support communication autonomous motivational support broader social environment future investigators healthcare providers consider integrating evidence based approaches support effects positive social climate based interventions promoting healthy eating physical activity weight management youth
objective study examined prospective association parental reports intimate partner violence ipv involvement perpetration victimization offspring trauma symptoms average years later moderating influence positive negative parenting method children community study followed representative sample youth generation parents generation years including offspring generation final assessments sample includes male female original generation study members completed measures ipv children generation wave parents completed measures parenting wave child trauma symptoms wave results ipv predicted child trauma symptoms controlling demographic risks fathers mothers association held controlling stressful life events psychopathology ipv predicted lower positive higher negative parenting practices positive parenting moderated association ipv child trauma symptoms conclusion childhood exposure ipv parents may increase distal risk trauma symptoms ipv predicts negative less supportive parenting practices positive parenting may protective though perhaps extreme levels ipv
backgroundmultiple allergic sensitizations common persistent childhood asthma thorough assessment allergy crucial optimal care children microarray testing offers opportunities improved sige characterization projected useful management multisensitized patients objectivethe aim study investigate accuracy information obtained two microarray platforms applied well characterized pediatric asthma cohort methodsseventy one children recruited nationwide swedish study severe childhood asthma severe controlled asthmatics assessed allergic sensitization two microarray systems microtest isac two standard diagnostic methods immunocap skin prick test data clinical history physical examination spirometry asthma control test doctor diagnosis collected results four diagnostic methods analyzed compared resultsa high prevalence allergic sensitization observed cohort pairwise concordance two methods independently methods compared sensitivity four methods doctor diagnosis specificity microarray methods provided new information sensitized children comparison results obtained standard diagnostic methods conclusionthe high prevalence food respiratory sensitization supports clinical guideline recommendation allergies evaluated children suspected asthma microarray platforms studied demonstrated acceptable accuracy provided refined ige characterization patients compared standard extract based methods
one main difficulties acoustic echo cancelation aec adaptation strategy adaptive filter different situations recently kalman filter theory introduced accommodate adaptation control aec applications due optimal performance many system identification problems paper frequency domain simplified kalman filter partitioned block based aec studied contribution twofold first relationship kalman filter optimal variable step size algorithm revealed contributes motivation paper second influence system uncertainty performance kalman filter analyzed new uncertainty control method developed simulation results confirm superiority proposed method conventional ones
photosynthetic performance leaf gas exchange chlorophyll chla fluorescence activities antioxidant enzymes superoxide dismutase sod catalase cat peroxidase pox ascorbate peroxidase apx concentrations hydrogen peroxide malondialdehyde mda flag leaves plants two wheat cultivars contrasting levels resistance spot blotch assessed spot blotch severity significantly lower plants compared guamirim net carbon assimilation rate stomatal conductance concentrations chla chlab carotenoids significantly decreased fungal infection contrast internal concentration significantly increased fungal infection comparison non inoculated counterparts similarly inoculation significantly reduced photochemical performance inoculated flag leaves comparison non inoculated counterparts however plants able sustain greater functionality photosynthetic apparatus fungal infection process compared guamirim activities sod pox apx cat increased inoculated flag leaves cultivars compared non inoculated plants highest increases measured greater activities enzymes associated reduced concentration inoculated flag leaves resulting therefore lower mda concentration thus efficient antioxidative system flag leaves plays pivotal role removing excess reactive oxygen species generated infection process bipolaris sorokiniana therefore limiting cellular damage largely preserving photosynthetic efficiency infected flag leaves
little research investigated factors may moderate intergenerational transmission emotionally unsupportive parenting behaviors present study examined role two moderators emotion dysregulation maternal age childbirth relation maternal childhood history emotional maltreatment current observations emotionally unsupportive parenting behaviors mother child dyads results indicated mothers younger childbirth seemed likely engage emotionally unsupportive parenting behaviors context high levels sustained childhood emotional maltreatment regardless level emotion dysregulation mothers older childbirth high risk emotionally unsupportive parenting behaviors context high levels sustained emotional maltreatment histories high emotion dysregulation yet risk emotion dysregulation low implications buffering effects emotion regulation risk emotionally unsupportive behaviors discussed
nowadays denial service dos attacks become major security threat networks internet therefore even naive hacker launch large scale dos attack victim providing internet services article deals evaluation snort ids terms packet processing performance detection work describes aspect involved building campus network security system evaluates campus network security risks threats mainly analyses attacks dos ddos puts forward new approach snort campus network security solutions objective analyze functional advantages solution deployment configuration open source based snort intrusion detection system evaluation metrics defined using snort namely comparison basic rules new ones available bandwidth cpu loading memory usage
fundamental purpose sleep remains one compelling questions yet answered area neuroscience biology pervasive behavior among members animal kingdom functional necessity engaging regularly sleep best demonstrated showing failing leads broad repertoire pathological outcomes including cognitive immunological hormonal metabolic outcomes among others indeed absolute requirement sleep shown studies demonstrated continuous total deprivation sleep short period days generally lethal species common clinical sleep disorder insomnia principal disease primary insomnia well morbidity large number ostensibly unrelated diseases including chronic pain attention deficit hyperactivity disorder depression treatment perspective restoring normal healthy sleep delivers subsequent benefits waking cognitive function mood potential beneficial therapeutic impact daily functioning across multiple diseases restorative healthy sleep compromised remarkable escalation understanding anatomy physiology sleep wake control mechanisms provides new opportunities modify neurobiology sleep wake related behaviors novel exciting ways parallel expansion sleep research novel interfaces sleep wake biology disease states revealing additional extensive implications lost sleep current investigational conventional pharmacological approaches treatment sleep wake disorders discussed based mechanism action within cns effect sleep wake review recent sleep biology sleep pharmacology peers future sleep therapeutics highlight mechanistic safety functional outcomes key differentiating establishing success next generation arousal modifying therapeutics
backgroundthe relationship inadequate sleep mood well established adults supported primarily correlational data younger populations given adolescents often experience shortened sleep school nights sought better understand effect experimentally induced chronic sleep restriction adolescents mood mood regulation methodsfifty healthy adolescents ages completed week sleep manipulation protocol involving baseline week followed sleep restriction condition bed per night five nights healthy sleep duration condition bed per night five nights study used randomized counterbalanced crossover experimental design participants sleep monitored home via self report actigraphy end condition participants parents completed questionnaires mood mood regulation assess expectancy effects also analyzed parent teen ratings hyperactivity impulsivity prior research suggests sensitive adolescents wilcoxon signed rank tests compared questionnaire outcomes across two conditions resultsparticipants averaged hours sleep per night relative compared adolescents rated significantly tense anxious angry hostile confused fatigued less vigorous parents adolescents also reported greater oppositionality irritability poorer emotional regulation compared conclusionsfindings complement prior correlational study results show days shortened sleep level severity experienced regularly millions adolescents school nights adolescents worsened mood decreased ability regulate negative emotions
constructed insect computer hybrid legged robot using living beetle mecynorrhina torquata coleoptera protraction retraction levation depression motions forelegs beetle elicited electrically stimulating eight corresponding leg muscles via eight pairs implanted electrodes perform defined walking gait gallop different muscles individually stimulated predefined sequence using microcontroller different walking gaits performed reordering applied stimulation signals applying different sequences varying duration stimulation sequences successfully controlled step frequency hence beetle walking speed best knowledge paper presents first demonstration living insect locomotion control user adjustable walking gait step length walking speed
using baseline data randomized controlled pediatric obesity prevention trial study sought examine general parenting style potential moderator association feeding specific parenting practices child dietary intake four hundred twenty one parent child dyads served participants girls mothers children average years old either overweight risk overweight mean bmi percentile data collected participants homes study staff measured children height weight parents completed questionnaires designed assess general parenting styles authoritative authoritarian permissive child feeding practices restriction monitoring child dietary intake assessed using recall system outcomes daily servings fruits vegetables sugar sweetened beverages ssb unhealthy snacks results follows permissive parenting inversely associated fruit vegetable consumption parental monitoring inversely associated ssb consumption main effects parenting style feeding practice child dietary consumption authoritarian parenting moderated association restriction ssb intake marginally significant effect correcting multiple comparisons restriction inversely associated ssb consumption authoritarianism high unassociated ssb consumption authoritarianism low findings indicate parenting practice monitoring child dietary intake associated healthful consumption regardless parenting style interventions may thus benefit encouraging parental monitoring parenting strategy restricting child dietary intake contrast associated lower ssb intake context higher parental authoritarianism inconsequential context lower parental authoritarianism exploratory finding warrants investigation elsevier ltd rights reserved
background eating disorder otherwise specified ednos common eating disorder diagnosis routine clinical practice specific treatment methods diagnosis yet developed studied enhanced cognitive behavioral therapy cbt described put test transdiagnostic treatment protocol eds including ednos initial research suggests cbt effective eds especially bulimia nervosa ednos earlier version cbt positive results cbt replicated detail preferably independent researchers different countries first dutch study cbt results national multicenter study three sites specialized eds deliver important information effectiveness cbt several domains pathology providing input upcoming update dutch multidisciplinary guideline treatment eating disorders methods design multicenter randomized controlled trial conducted one hundred thirty two adult outpatients aged years older diagnosis body mass index bmi randomly allocated control intervention group subjects control group receive treatment usual standard outpatient treatment provided participating sites subjects intervention group receive sessions cbt weeks design group time repeated measures factorial design neither therapists patients blinded treatment allocation primary outcome measure recovery secondary outcome measures include psychopathology common mental disorders anxiety depressive symptoms health related quality life health care use productivity loss self esteem perfectionism interpersonal problems examined putative predictors mediators effect treatment also economic evaluation societal perspective undertaken relevant effects direct indirect costs included utility scores measure effects measurements take place pretreatment weeks weeks weeks weeks discussion effectiveness study cbt aim broadening scope generalizability former studies cbt appears least effective traditional diagnosis specific treatments broad range patients training one protocol would sufficient clinicians treat patients different kinds eds gives opportunity offer treatment severe mental disorder fewer resources thereby increasing accessibility specialized care patients
parkinson disease one common neural degenerative disease affecting millions people globally great progress made treatment one promising one stem cell based therapy thus studies differentiation neural stem cells nscs important advancement therapy study used rat nscs elucidate role lithium proliferation differentiation nscs immunostaining brdu analysis well immunostaining specific neuronal markers concluded lithium chloride licl treatment could enhance proliferation nscs promote dopaminergic neuronal differentiation nscs vitro process potentially mediated wnt signaling pathway using ohda induced models provided evidence show licl capacity enhance proliferation nscs differentiation towards dopaminergic neurons vivo beneficial effect licl treatment validated fact motor function well learning memory improved models rotarod test morris water maze analysis learning memory improvement supported increase dendrite spine density models receiving licl treated nscs study concluded lithium plays important role promoting nscs neuronal differentiation vitro improving symptoms models vivo great significance work showed potential application lithium therapy future
computer programming skills younger ages seem promising challenging aspect many visual programming tools developed order assist young students improve current teaching practices pedagogies paper explore potential effects project based learning pjbl approach field computer programming particular try identify potential differences students programming habits styles game development simulation traditional learning strategy context pjbl sample consisted middle school students formed three groups introducing programming serious game development approach might inspire students towards creative learning experience moreover parameters like class formation might affect development programming skills students pjbl treatment able complete project successfully making fewer mistakes hand students enrolled traditional top approach chose experiment complex curriculum always successfully
vasectomy contraceptive method safer less invasive easier practice bilateral tubal ligation however less commonly used especially developing countries like mexico present study sought determine whether demographic gender ideology variables related beliefs attitudes toward vasectomy three hundred eighty nine mexican adults surveyed neither male participants partners female participants vasectomy examined participants beliefs attitudes toward vasectomy gender role ideology marriage ambivalent sexism pearson correlations multivariate analyses covariance linear regressions used analyze data men participants limited education showed negative attitudes toward vasectomy belief vasectomy decreases virility common agreed female subordination marriage women participants higher education agree male infidelity marriage participants endorsed benevolent sexism likely acknowledge benefits vasectomy men participants agreed female subordination marriage likely express fear surgical procedure unfavorable ideas toward vasectomy increased participants lower education agreed female subordination marriage health practitioners researchers take account psychosociocultural factors concerning vasectomy order better understand acceptance rejection provide accurate current contraceptive counseling encourages choice method
basophil activation test bat suggested complementary method diagnosing drug allergies aim study evaluate clinical utility test patients drug induced anaphylaxis total patients history moderate severe anaphylaxis enrolled none causative drugs available vitro tests reliable skin tests drugs included among others first second generation cephalosporins blockers muscle relaxants bat yielded positive results cases similar results skin prick intradermal tests respectively basophils double labelled cdc basophil activation markers positive rate increased therefore results study confirm bat quick reliable safe diagnostic tool patients drug induced anaphylaxis
objective evaluate dose response relationship smoking load cardiopulmonary fitness measured cardiopulmonary exercise testing cpet adult smokers free respiratory diseases methods complete clinical evaluation spirometry adult smokers men women underwent cpet treadmill results physiological responses cpet showed lower cardiorespiratory fitness levels regardless smoking load peak lower expected value lower maximum heart rate observed significant moderate negative correlation smoking load peak smoking load also presented significant negative correlation maximum heart rate lactate threshold peak ventilation however dose response relationship smoking load quartiles cardiopulmonary fitness found comparing quartiles smoking loads adjustment age sex cardiovascular risk conclusion appears dose response relationship cardiopulmonary fitness adult smokers preserved pulmonary function adjusting analysis age cardiovascular risk results suggest smoking cessation might useful primary strategy prevent cardiopulmonary fitness decline smokers regardless smoking load thus even low dose tobacco use must avoided preventive strategies focusing becoming people physically active fit sociedade portuguese pneumologia published elsevier espana open access article license
purpose review paper presents review current state art remote sensing based monitoring forest disturbances forest degradation optical earth observation data part one comprises overview tabular description currently available optical remote sensing sensors used forest disturbance degradation mapping part two reviews two main categories existing mapping approaches first classical image image change detection second time series analysis recent findings launch sentinel satellite available landsat imagery time series analysis become promising also demanding category degradation mapping approaches four time series classification methods distinguished methods explained benefits drawbacks discussed separate chapter presents number recent forest degradation mapping studies two different ecosystems temperate forests geographical focus europe tropical forests geographical focus africa summary review revealed wide variety methods detection forest degradation already available today main challenge transfer approaches high resolution time series data multiple sensors future research also focus classification disturbance types development robust scalable methods enable near real time disturbance mapping support operational reactive measures
article aims investigating backgrounds applications research progresses micro nano robotics biomedical applications home abroad based core technology summarized fabrication control smart material simulation mechanism biological medicine etc urgently need solved challenges potential trends micro nano robotics biomedical applications discussed
study presents review heat transfer treatment hcci phenomenological simulation models including single zone multi zone ones heat transfer within combustion chamber significant modeling internal combustion engine general hcci combustion process particular determines great extent temperature field within combustion chamber throughout engine operating cycle especially compression combustion hcci engines combustion relies upon auto ignition premixed charge present compression stroke combustion mode heat transfer process directly affects mean gas local temperatures thereby influencing ignition timing combustion rate formation nox emissions success simulation model describing predicting hcci combustion process emissions formation evidently depends partly ability reliably predict heat transfer phenomena involved despite importance heat transfer process hcci simulation little progress made past years compared advances achieved experimentally moreover information regarding phenomenological heat transfer treatment scattered aforementioned provided motivation review provides initially critical outlook heat transfer correlations derived conventional combustion modes since correlations still used frequently hcci simulation models underlying assumptions correlations conditions validated explicitly stated order appraise suitability hcci phenomenological simulations heat transfer treatment single zone multi zone models presented subsequently including hcci specific correlations developed past years issues zone configuration wall heat transfer correlations based global local gas properties inter zonal heat transfer discussed moreover comparative studies evaluate relative effectiveness different correlations presented study concludes general remarks phenomenological heat transfer simulation suggestions research elsevier ltd rights reserved
objective increasing use long acting methods contraception intrauterine devices iuds recognized promising strategy reduce incidence unintended pregnancy men may play important role promoting discouraging contraceptive use little research examined men knowledge attitudes toward iuds study design used data men included national survey reproductive contraceptive knowledge examine awareness knowledge iuds contraceptive methods several individual level characteristics results men awareness perceived knowledge iuds low comparison condoms birth control pills men perceived knowledge iuds lower objective knowledge measured true false questions iuds suggesting men may knowledgeable iuds perceive multivariate models men uninsured adjusted odds ratio aor confidence interval identified christian aor never sexual health visit aor less likely heard iuds among men heard method hispanic men less likely aor knowledgeable method conclusion young men report low awareness iuds comparison methods varies demographic characteristics including health insurance status family planning programs consider targeted knowledge promotion young men focus contraceptive methods besides condoms oral contraception elsevier inc rights reserved
examined intergenerational transmission parent child relationship qualities population based finnish sample participants mothers baseline mage reported qualities parent child relationship terms emotional warmth acceptance towards age range years mage rated qualities parent child relationship regarding children using questionnaire emotional warmth acceptance transmitted across generations even controlling demographic family characteristics generations transmission stronger emotional warmth acceptance emotional warmth intergenerational transmission stronger men women findings provide evidence long term transmission parenting quality across generations
green building concept recently gained momentum success green projects large extent depends life cycle cost water conservation components contribute almost capital cost conventional residential building paper aims analyze financial feasibility using water conservation components evaluating lifecycle costs operational savings large mass housing projects four components evaluated case project located metropolitan suburban location india analyze benefits two different water tariffs considered local corporation combined mineralized water well water lifecycle cost analysis lcca suggests excluding rainwater harvesting component significant share cost components related maintenance repair replacement activities results analysis suggest water components pay return local corporation water tariff considered discount rate results study expected benefit project stakeholders mass housing projects financial budgetary decisions thus making implementation component based designs feasible american society civil engineers
spreading depolarizations cause cortical electrical potential changes wide spectral range includes slow potentials approaching direct current level negative direct current shift important identifier cortical depolarization duration measure potential tissue injury associated longer lasting depolarizations determine feasibility monitoring full signal bandwidth spreading depolarizations patients performed subdural electrocorticography using platinum electrode strips direct current coupled amplifiers patients acute brain injury two neurosurgical centers large baseline direct current offsets developed loss data due amplifier saturation minimal rates baseline drift throughout recordings generally low transient negative direct current shifts spreading depolarizations easily recognized cases stereotyped measurable characteristics following standardized training session novice scorers achieved high degree accuracy interobserver reliability identifying depolarizations suggesting direct current coupled recordings facilitate bedside diagnosis future trials clinical decision making conclude intracranial monitoring slow potentials achieved platinum electrodes unfiltered direct current coupled recordings advantageous identifying assessing impact spreading depolarizations
performing electron tomography tilt series images often acquired samples contain unwanted carbonaceous material embedding resin thin carbon support film hydrocarbon contamination presence layers introduce artefacts reconstructions obscuring features interest illustrate benefit preprocessing high angle annular dark field tomographic tilt series thresholding unwanted low densitymaterials using simple intensity downshifting procedure resulting tomograms fewer artefacts segmentation performed accurately present two representative examples taken studies catalyst nanoparticles amyloid plaque core material human brain
background exposure multiple types air pollution may contribute exacerbate allergic diseases including asthma wheezing however studies examined chronic air pollution exposure allergic disease outcomes among adult population associations potential estimates annual average fine particulate matter traffic related air pollution industrial source air emissions three allergic disease outcomes asthma allergies wheezing examined state wide general population adults methods study includes representative sample adult wisconsin residents participated survey health wisconsin show program participant data geographically linked united states environmental protection agency usepa baysian space time downscaler air pollution model united states census roadway usepa toxic release inventory data self report lung function fev estimates used define prevalence asthma allergies wheezing symptoms results annual mean exposure fine particulate matter increase annual mean resulted increase adjusted odds asthma exposure vehicle traffic increased odds current allergies current asthma living within interstate roadway associated fold increase odds asthma living within industrial site likely asthma significant associations seen wheezing conclusions within population exposed overall annual average levels estimated low level chronic exposure fine particulate matter near usepa standard air quality significant association modeled exposure proximity roadways asthma allergies wheezing found industrial source emissions associated allergic disease outcomes
background kawasaki disease acute vasculitis childhood leads coronary artery aneurysms approximate untreated cases reported worldwide leading cause acquired heart disease children developed countries methods results revise previous american heart association guidelines multidisciplinary writing group experts convened review appraise available evidence practice based opinion well provide updated recommendations diagnosis treatment acute illness long term management although cause remains unknown discussion sections highlight new insights epidemiology genetics pathogenesis pathology natural history long term outcomes prompt diagnosis essential updated algorithm defines supplemental information used assist diagnosis classic clinical criteria incomplete although intravenous immune globulin mainstay initial treatment role additional primary therapy selected patients discussed approximately patients respond initial intravenous immune globulin recommendations additional therapies provided careful initial management evolving coronary artery abnormalities essential necessitating increased frequency assessments escalation thromboprophylaxis risk stratification long term management based primarily maximal coronary artery luminal dimensions normalized scores calibrated past current involvement patients aneurysms require life long uninterrupted cardiology follow conclusions recommendations provide updated best evidence based guidance healthcare providers diagnose manage kawasaki disease clinical decision making individualized specific patient circumstances
mixed urinary incontinence though common often challenging clinicians treat guidelines best practice statements published overactive bladder stress urinary incontinence respectively rely current research data support treatment decisions mixed urinary incontinence goal paper review research better understand outcomes expected patients mixed urinary incontinence undergo mid urethral sling seven articles published reviewed directly addressed clinical question greater subjective cure rate urgency related symptoms reported studies high age body mass index previous incontinence surgeries found influence outcomes improvement urge related symptoms commonly seen sling placed mixed urinary incontinence managing patient expectations patient education critical difficult clinical scenarios
although exact pathophysiology remains unknown development inflammatory bowel disease ibd influenced interplay genetics immune system environmental factors diet commonly used food additives carrageenan carboxymethylcellulose cmc used develop intestinal inflammation animal models food additives excluded current dietary approaches induce disease remission crohn disease exclusive enteral nutrition een using polymeric formula reviewing existing scientific literature review aims discuss role carrageenan cmc may play development ibd animal studies consistently report carrageenan cmc induce histopathological features typical ibd altering microbiome disrupting intestinal epithelial barrier inhibiting proteins provide protection microorganisms stimulating elaboration pro inflammatory cytokines similar trials directly assessing influence carrageenan cmc humans course unethical conduct recent studies human epithelial cells human microbiome support findings animal studies carrageenan cmc may trigger magnify inflammatory response human intestine unlikely identified sole environmental factor involved development ibd disease recurrence treatment however widespread use carrageenan cmc foods consumed pediatric population western diet rise alongside corresponding increase ibd incidence questions raised safety frequent usage food additives therefore research warranted elucidate role carrageenan cmc intestinal inflammation may help identify novel nutritional strategies hinder development disease prevent disease relapse post een treatment
study design prospective multicenter cohort study years outpatients rheumatoid arthritis objective identify predictive risk factors cervical spine instabilities may induce compression myelopathy patients summary background data many reports described natural course cervical spine involvement studies however conducted comprehensive evaluation prognostic factors methods cervical spine instability radiographically defined atlantoaxial subluxation atlantodental interval greater vertical subluxation ranawat value less subaxial subluxation irreducible translation higher severe category instability defined atlantoaxial subluxation atlantodental interval lower vertical subluxation ranawat value higher subaxial subluxation translation higher multiple levels definite classical patients without baseline severe instability prospectively followed throughout years cox proportional hazards regression analysis performed determine predictors development severe instabilities exclude biases low follow rate similar assessments performed patients followed years baseline results incidence cervical spine instabilities severe instabilities significantly increased years cohorts multivariable cox proportional hazards models found baseline mutilating changes hazard ratio confidence interval corticosteroid administration previous joint surgery correlated progression severe instability cases also cases respectively conclusion established mutilating changes concomitant corticosteroid treatment previous joint surgery relatively robust indicators poor prognosis cervical spine patients based consistency year analysis two different settings
context component based software systems require decisions component origins acquiring components component origin alternative get component objective identify factors could influence decision choose among different component origins solutions decision making example optimization literature method systematic review study peer reviewed literature conducted results total included primary studies component origins compared mainly focused house cots cots oss identified factors affecting influencing decision select component origin component origins compared little evidence relative either positive negative effect component origin factor solutions proposed house cots selection time cost reliability considered factors solutions optimization models commonly proposed technique used solutions conclusion topic choosing component origins green field research great need empirical comparisons component origins well decide different combinations elsevier inc rights reserved
prominent pattern cognitive change lifespan centers difference patterns maintained abilities tests crystallized knowledge patterns steady decline tests problem solving processing speed whereas maintained vulnerable dichotomy well established literature questions remain cognitive decline problem solving processing speed controlled relationship examined cross sectional studies typically used non clinical tests non representative samples adults study extended findings popular clinical test wechsler adult intelligence scale wais using carefully stratified sample source data ages indexes ages perceptual reasoning subtests multivariate analysis covariance mancova revealed variance declining reasoning ability shared speed factor true index subtest level regardless type problem solving task employed robust findings important clinical research implications neuropsychologists frequently use wechsler scales part assessment battery
construction management construction enterprise according business development strategy enterprise internal external conditions accordance modern enterprise operation law optimized allocation production factors dynamic management
cardiovascular disease leading cause death world dyslipidemia manifested elevated low density lipoprotein cholesterol ldl levels central development progression atherosclerosis dyslipidemia become primary target intervention strategies prevention cardiovascular events therapeutic lifestyle changes increased physical activity weight loss smoking cessation adoption healthier diet effectively reducing cardiovascular risk primary secondary prevention combination therapy lowered ldl levels achieved ldl target patients high cardiovascular risk elsevier journals inc rights reserved
androgen replacement therapy male hypogonadism may prescribed utilizing intramuscular oral recently topical formulations topical formulations risk person person transmission appropriate precautions taken describe two cases virilization pre pubertal children following passive transfer paternal topical testosterone month old male referred week history pubic hair phallic growth linear growth spurt genital examination revealed tanner stage pubic hair tanner stage phallic development discordant pre pubertal testicular size bilaterally year month old girl referred month history increasing pubic hair development examination revealed tanner stage pubic hair tanner stage breast development patients fathers diagnosed hypogonadism treated topical androgen gel therapy applied arms chest bed addition patients often slept parents resulting skin skin contact investigations consistent gonadotropin independent virilization patients demonstrating elevated testosterone levels testosterone levels returned normal pre pubertal levels development secondary sexual characteristics following discontinuation exposure topical testosterone precautions must taken prevent person person transfer topical steroids increasing popularity topical steroids treatment low testosterone imperative therapies prescribed utilized judiciously prevent harm specifically gonadotropin independent virilization
background pregnancies united states unintended meaning pregnancy mistimed unplanned unwanted unintended pregnancy increases health risks mother child leads high economic costs society increases social disparities mobile phone ownership rapidly increasing providing opportunities reach risk populations reproductive health information tailored unintended pregnancy prevention interventions mobile phone apps however apps offer support unintended pregnancy prevention remain unevaluated objective identify describe evaluate mobile phone apps purport help users prevent unintended pregnancy methods conducted extensive search apple itunes android google play stores apps explicitly included advertised pregnancy prevention decision making support context fertility information tracking birth control reminders contraceptive information pregnancy decision making abortion information counseling sexual communication negotiation pregnancy tests excluded apps targeted medical professionals cost eligible apps downloaded categorized primary purpose data extraction performed minimum attributes domains pregnancy prevention best practices contraceptive methods clinical services user interface apps assigned points inclusion features overall pregnancy prevention best practices contraceptive information results search identified app descriptions itunes google play unique apps met inclusion criteria included review apps grouped categories fertility trackers centers resources birth control reminders general sexual reproductive health srh information srh information targeted specifically young adults contraceptive information service condom locators pregnancy tests games twelve apps scored least points overall number features least points contraceptive information pregnancy prevention best practices overall apps mention modern contraceptive methods mentioned method apps mention modern contraceptive method fewer apps provided information use srh apps highest percentage pregnancy prevention best practices app demographic interface evaluation found apps target race explicitly targeted youth communication interface features present fewer apps conclusions review identified several useful evidence based apps support prevention unintended pregnancy however apps miss opportunities provide users valuable information interactive decision aids evidence based interventions unintended pregnancy prevention apps space may increase likelihood unintended pregnancy due low effectiveness contraceptive methods promoted
background wnt signaling plays important role development maintenance many organs tissues studied secreted wnt inhibitors sclerostin sost dickkopf related protein dkk secreted frizzled related protein sfrp play important roles bone turnover present study investigated relationship serum wnt inhibitors diseases excessive ossification structures ossification posterior longitudinal ligament opll ankylosing spondylitis diffuse idiopathic skeletal hyperostosis dish ossification yellow ligament oyl methods twenty five patients dish opll oyl recruited study fasting peripheral blood samples collected patients nine controls various biomarkers bone turnover including osteocalcin osc osteoprotegerin opg sfrp dkk sost investigated results data showed serum levels osc higher dkk levels lower dish opll oyl patients controls serum levels sfrp significantly higher dish patients controls serum levels sost significantly higher dish opll patients levels controls serum levels opg lower patients controls serum levels osc higher opll patients patients serum levels dkk sfrp sost opg significantly different different disease groups conclusions exploratory study osc dkk levels correlated clinical conditions associated excessive ossification indicating blood osc dkk levels may serve diagnostic biomarkers dish opll oyl findings may also help discover potential drug therapies management diseases future
background basic translational research supports beneficial effects statins bone metabolism clinical studies suggest statin use may reduce risk hip fractures general population whether statin use associated hip fracture risk kidney transplant recipients particularly high risk group outcome unknown methods renal data system identified hip fracture events recorded medicare billing claims first time kidney transplant recipients matched cases unlimited number controls age years sex race black non black time since transplant cases controls required year medicare parts coverage without recorded history hip fracture ascertained statin use previous year defined adherent statin use filled prescriptions statins cover days year proportion days covered pdc ascertained several potential confounders demographics comorbidities bmi transplant related factors applied conditional logistic regression multiple imputation missing data estimate odds ratios confidence intervals results identified hip fracture cases mean age years female black years transplant years esrd matched controls prior statin use present cases controls cases controls found adherent unadjusted conditional logistic regression showed statin use fully adjusted compared statin non users adjusted patients lesser adherence pdc respectively conclusion statin use associated hip fracture risk first time kidney transplant recipients
introduction current small pilot naturalistic cross sectional study assesses whether higher dosages anti psychotics related satisfactory outcome concerning symptoms schizophrenia also worse outcome terms adverse events neurocognitive function material methods male stabilized hospitalized schizophrenic patients assessed panss calgary depression rating scale simpson angus scale battery neurocognitive tests medication dosage prescribed according clinical judgement therapist results clinical variables adverse events differ patients recommended high dosage groups higher dosage correlated depressive symptoms correlation neurocognitive measures except impaired concentration discussion results suggest possible achieve good clinical response refractory patiefits exceeding recommended antipsychotic dosages price depression possible mild isolated concentration deficits neurocognitive extrapyramidal adverse events currently clinicians prefer first generation antipsychotics high dosages prescribed considering favorable adverse effects profile newer agents important study higher dosages agents test whether preferably given high dosages necessary published elsevier inc
increasing need building models permit interior navigation escape route analysis paper presents non manifold computer aided design cad data structure dual half edge based poincare duality expresses geometric representations individual rooms topological relationships volumes faces expressed vertices edges respectively dual space permitting model based storage primal dual vertices edges attributes may attached entities permitting example shortest path queries specified rooms exterior storage costs shown comparable non manifold models construction local euler type operators demonstrated two large university buildings intended enhance current developments geographic information systems interior exterior city modelling
patients antisocial personality disorder outpatient treatment substance use disorders high risk drop using randomized design study tested impact adding brief psycho educational program impulsive lifestyle counseling program outpatient substance abuse treatment order prevent treatment dropout patients recruited municipal treatment centers denmark assigned treatment usual experimental condition patients could included analyses intent treat analysis risk treatment dropout reduced among patients randomized experimental program hazard ratio controlling age gender substitution treatment status study supported efficacy impulsive lifestyle counseling program method preventing treatment dropout patients comorbid antisocial personality disorder substance abuse treatment trial registration isrctn elsevier ltd rights reserved
bootstrap popular powerful method assessing precision estimators inferential methods however massive datasets increasingly prevalent bootstrap becomes prohibitively costly computation feasibility questionable even modern parallel computing platforms recently kleiner authors proposed method called blb bag little bootstraps massive data computationally scalable little sacrifice statistical accuracy building blb idea fast double bootstrap propose new resampling method subsampled double bootstrap independent data time series data establish consistency subsampled double bootstrap mild conditions independent dependent cases methodologically subsampled double bootstrap superior blb terms running time sample coverage automatic implementation less tuning parameters given time budget advantage relative blb bootstrap also demonstrated numerical simulations data illustration supplementary materials article available online
background aims whether high intakes fish long chain omega polyunsaturated fatty acids pufas reduce risk atrial fibrillation remains uncertain thus aimed evaluate associations total fish types fish omega pufa intake incidence large prospective study methods used data cohort swedish men swedish mammography cohort examine associations fish consumption long chain omega pufa intake incidence baseline information fish omega pufa intakes available men women aged years without cardiac disease cases identified linkage swedish national patient register multivariable adjusted relative risks estimated use cox proportional hazards models results follow period years participants men women developed intakes total fish fatty fish herring mackerel salmon whitefish char long chain omega pufas associated incidence adjustment risk factors however high consumption lean fish cod saithe fish fingers associated lower risk multivariable relative risk servings week compared never consumption confidence interval conclusions findings support beneficial association fatty fish omega pufa intake incident association lean fish consumption risk warrants investigation elsevier ltd european society clinical nutrition metabolism rights reserved
sleep disturbance cognitive dysfunction two domains impairment inter episode bipolar disorder despite evidence demonstrating importance sleep cognition healthy sleep disordered samples link minimally examined bipolar disorder present study tested association insomnia related sleep disruptions cognitive dysfunction inter episode bipolar disorder forty seven participants bipolar disorder comorbid insomnia diagnosis insomnia participants bipolar disorder without sleep disturbance last six months control participated study two domains cognition assessed working memory verbal learning insomnia related sleep disruptions assessed categorically insomnia diagnosis dimensionally total wake time total sleep time total wake time variability total sleep time variability hierarchical linear regressions adjusting participant age demonstrated insomnia diagnosis independent interactive effect cognition however regardless insomnia diagnosis greater total sleep time variability predicted poorer working memory verbal learning performance following sleep treatment reduction total wake time predicted improved working memory performance reduction total sleep time variability predicted improved verbal learning performance findings raise possibility sleep disturbance may contribute cognitive dysfunction bipolar disorder highlight importance treating sleep disturbance bipolar disorder published elsevier ltd
objective ulipristal acetate upa safe effective emergency contraception prospective open label exploratory study conducted obtain additional data pharmacodynamic effects repeated dose upa week period effects ovulation inhibition hormonal levels endometrium cervical mucus safety tolerability data repeated use upa also collected study design total healthy female healthy sterilized women participated two substudies receiving upa consecutive weeks substudy upa administered every days substudy every days subjects monitored three times week baseline cycle treatment transvaginal ultrasounds hormonal measurements cervical mucus evaluation laboratory safety measurements standard surrogate thrombosis risk markers measured baseline within days last tablet luteal phase endometrial biopsy taken baseline cycle posttreatment results total subjects ovulated least substudy respectively similar normal hormonal profiles effect cervical mucus observed biopsies classified benign substudies biopsies posttreatment classified nonphysiological typical progesterone receptor modulator associated endometrial changes upa well tolerated treatment arms clinical laboratory results surrogate thrombosis markers reassuring conclusions repeat use oral upa every days weeks initially delays follicular rupture ovulation eventually occurs time subjects safety data indicate upa could safely administered needed given menstrual cycle elsevier inc rights reserved
disgust disease related cues activate immune system test whether immuno suppression associated regulation cognitions behaviors assist disease avoidance people rheumatoid arthritis heightened risk infection related morbidity mortality compared age gender demographically matched healthy controls range disease avoidance tasks people scored higher reports behavior likely control infection accurate spotting individuals sick showed disease specific ethnocentrism ascribing greater risk contracting disease non caucasians although overall propensity greater racism modern racism scale contrary predictions disgust sensitivity differ groups however among people found lower taking drugs increase infection risk explicit disease avoidance behaviors clearly regulated people changes may different perhaps biological casual basis elsevier inc rights reserved
information knowledge society live observe ever greater extent proliferation rise devices smartphones tablets phablets impacting models new learning assumptions lifestyles communication relationships new era citizen entertainments factors implications educational context education needed develop efficent ways order overcome different challenge ambivalent social panorama methodological teaching problems organizational aspects curricular design learning spatial temporal rethinking required form innovative perspective order develop new trends emerging technologies according different editions report nmc horizon report implementation new technologies classroom using augmented reality gamification mobile learning opportunity reshape educational practices accord new features demands needs students thus paper review analysis applications softwares different devices operating systems developed reflexion proposals activities ict developing teaching second language field communicative approach
previous studies shown cost ectiveness quality life benefit pneumatic compression therapy pct lymphedema insurers centers medicare medicaid cms however desire visual proof pct moves lymph near infrared fluorescence lymphatic imaging nirfli used visualize lymphatic anatomy function four subjects primary cancer treatment related lower extremities pct optically transparent windowed pct garments allowed visualization lymph movement single pct treatment sessions visualization revealed significant extravascular lymphatic vascular movement intradermally injected dye subjects one subject sufficient patent lymphatic vessels allow quantification lymph pumping velocities frequencies values significantly increased pct compared pre treatment values lymphatic contractile activity patent lymphatic vessels occurred concert sequential cycling pct direct visualization revealed increased lymphatic function pct therapy affected extremities studies warranted assess erects pct pressure sequences lymph uptake movement
objective primary aim study determine prevalence one season incidence symptoms common mental disorders cmd distress anxiety depression sleep disturbance eating disorders adverse alcohol use among european professional football referees secondary aim explore view european professional football referees consequences support needs related symptoms methods observational prospective cohort study three measurements follow period one season conducted among central assistant professional football referees belgium finland france germany norway russia scotland sweden using validated questionnaires assess symptoms cmd self reported clinically diagnosed electronic questionnaire english french set distributed eight football federations involved results total referees mean age years old mean career duration years enrolled completed follow period baseline week prevalence rates distress anxiety depression sleep disturbance eating disorders adverse alcohol use one season incidence symptoms cmd distress anxiety depression sleep disturbance eating disorders adverse alcohol use conclusion symptoms cmd occur among professional football referees influence negatively refereeing performances development specific support measures referees needed order manage properly symptoms cmd
reliable valid measures pain intensity needed accurately evaluate efficacy pain treatments perhaps exception faces pain intensity scales thought reflect pain intensity pain affect commonly used pain intensity scalesnumerical rating scales nrss visual analog scales verbal rating scales vrss thought reflect primarily pain intensity magnitude felt pain however knowledge assumption directly tested vrss methodswe evaluated whether vrs pain severity ratings influenced pain beliefs catastrophizing pain interference effects pain intensity measured nrs samples individuals physical disabilities chronic pain resultsas hypothesized controlling pain intensity measured nrs higher scores factors representing pain interference function pain catastrophizing number pain related beliefs associated tendency study participants rate pain severe vrs discussionthese findings indicate vrss pain severity necessarily assumed measure pain intensity may also reflect patient perceptions pain interference beliefs pain clinicians researchers take findings account selecting measures interpreting results studies using vrss outcome measures
paper presents elastic transactions appealing alternative traditional transactions particular implement search structures shared memory multicore architectures upon conflict detection elastic transaction might drop far within separate transaction immediately commits resume computation within new transaction might elastic present elastic transaction model implementation illustrate simplicity performance various concurrent data structures namely double ended queue hash table linked list skip list elastic transactions outperform classical ones various workloads improvement average also exhibit competitive performance compared lock based techniques much simpler program lock free alternatives elsevier inc rights reserved
signal detection presence high noise challenge natural sciences understanding signals emanating deep space probes signals protein interactions systems biology domain specific innovations needed present work domain transfer alignment deals estimation misalignment deliverable daughter munitions respect delivering mother platform domain design noise filtering scheme consider time varying nonlinear system dynamics play accuracy conventional particle filter formulation suffers due deviations modeled system dynamics evolutionary particle filter overcome problem evolving multiple system models support points per particle however variant even higher time complexity real time execution result measurement update gets deferred estimation accuracy compromised running filter algorithms multiple processors execution time reduced allow frequent measurement updates scheme ensures better system identification performance improves case simultaneous ejection multiple daughters also results better convergence algorithms single daughter
article present problems improving access electrical network new customers characterizes influence terms costs connection distribution network favorable investment climate aspects grid companies network connection activities russian federation different countries studied summarized connection charge formation principles methods used government regulators different jurisdictions summarized finally proposals recommendations improving russian federation electricity distribution network connection suggested
letter presents improved backward forward sweep algorithm three phase load flow analysis radial distribution systems backward sweep kirchhoff current law kirchhoff voltage law used calculate upstream bus voltage line transformer branch linear proportional principle adopted find ratios real imaginary components specified voltage calculated voltage substation bus forward sweep voltage downstream bus updated real imaginary components calculated bus voltage multiplying corresponding ratio procedure stops mismatch calculated specified voltages substation less convergence tolerance proposed algorithm tested three ieee benchmark distribution systems results show algorithm accurate computationally efficient comparing two commonly used methods
rising air water pollution become issues widespread public concern india relationship spatial distribution environmental pollution social disadvantage received less attention lack attention becomes particularly relevant context industrial pollution india continues pursue industrial development policies without sufficient regard adverse social impacts letter examines industrial pollution india environmental justice perspective presenting national scale study social inequities distribution industrial hazardous waste generation analysis connects district level data national inventory hazardous waste generating industries variables representing urbanization social disadvantage socioeconomic status census india results indicate urbanized densely populated districts higher proportion socially economically disadvantaged residents significantly likely generate hazardous waste quantity hazardous waste generated significantly higher urbanized sparsely populated districts higher proportion economically disadvantaged households accounting relevant explanatory factors literacy social disadvantage findings underscore growing need incorporate considerations future industrial development waste management india
purpose study examine types parental involvement associated independent music lessons self report survey designed explore parent characteristics parental goals students musical progress teacher student relationship practice environment parent behaviours practice sessions extent outcomes enjoyment progress could predicted parenting goals values time spent practising teacher qualities student self regulation also examined survey distributed canada royal conservatory yielding surveys analysis results indicated parents deeply invested children music lessons reflected years commitment music instruction thoughtful roles took supporting children evolution self regulating musicians respect held children teachers evidence suggested positive teacher student relationships parental involvement practice sessions lessons predicted student enjoyment music musical progress
social media technologies become increasingly useful tools research based interventions however participants social media users expressed ethical concerns studies risks benefits participation well privacy confidentiality informed consent issues study designed follow assess experiences perceptions ethics related issues among sample men sex men participated harnessing online peer education hope peru study randomized controlled hiv prevention intervention conducted peru found adjusting age highest educational attainment race sexual orientation prior hiv research experience participants intervention group likely control group safe sex get tested hiv regularly result participation intervention group benefited positively participants control group improving hiv care learning receive sexual health services participants intervention group expressed higher levels comfort control group joining seeing people facebook group seeing people posts group members talk online discuss implications results relate social media based hiv research
aim paper present model takes account aspects related manufacturing engineering research development projects proposed model integrates tools dfma design manufacturing assembly mrl manufacturing readiness level design manufacturing assembly used method provide guidance design team simplifying product structure reduce manufacturing assembly costs quantify improvements manufacturing readiness level mrl measure assess maturity manufacturing readiness similar technology readiness levels trl used technology readiness proposed method applied research development project refrigeration industry technology definition phase results significant change product design bringing benefits reduction investment product cost also possible perceive anticipation manufacturing project working simultaneously technology maturation allowing reliable debugging product permitting reduction lead time
examine differential effects mental pain suicidal tendencies female victims sexually physically abused hypothesizing sexual abuse victims report mental pain suicidal tendencies physical abuse victims group women completed questionnaires measured mental pain suicidal tendencies thoughts demographic details sexual abuse victims suffered mental pain physical abuse victims physical abuse victims demonstrated repulsion life sexual abuse victims sexual abuse victims demonstrated less attraction life physical abuse victims showed attraction death
acquisition information parallel sensory pathways hallmark coordinated movement animals insect flight example relies mechanosensory visual pathways challenge disentangle relative contribution modality control behavior toward end show experimental analytical framework leveraging sensory conflict means independently exciting modeling separate sensory pathways within multisensory behavior model examine hovering flower feeding behavior hawkmoth manduca sexta laboratory moths feed robotically actuated two part artificial flower allows independent presentation visual mechanosensory cues freely flying moths track lateral flower motion stimuli assay spanning coupled motion visual mechanosensory cues follow motion trajectory sensory conflict two sensory modalities encode different motion stimuli applying frequency domain system identification analysis find tracking behavior fact multisensory arises linear summation visual mechanosensory pathways response dynamics highly preserved across individuals providing model predicting response novel multimodal stimuli surprisingly find pathway sufficient driving tracking behavior multiple sensory pathways elicit strong behavioral responses parallel architecture furnishes robustness via redundancy
crucial problem modern software engineering maturity assessment organizations developing software however research shown efficiency clearer indicator agile transformation readiness propose utilizing process model rup development methodology pattern comparing examined process two factors proposed assess maturity factor determining efficiency rup process mentioned rup model concept based multi agent based simulation mabs presents goals behaviours agents well components agent system environment confirm usefulness method assessment organization maturity two fold experiment undertaken results confirm usefulness model efficiency maturity assessment first part consisted tuning simulation internal parameters development process second part propose three factors used assess efficiency maturity rup organization proposed coefficients extension previous research authors devoted assessment organizational readiness agile processes transformation
international league dermatological societies ilds global profit organization representing dermatological societies worldwide identified consequences skin aging one important grand challenges global skin health reduced functional capacity increased susceptibility skin development dermatoses dry skin itching ulcers dyspigmentation wrinkles fungal infections well benign malignant tumors common skin conditions aged populations worldwide environmental pollution lifestyle factors smoking sunbed use negatively affect skin health turn altered appearance dry skin chronic wounds conditions decrease general health reduce likelihood healthy active aging preventive skin care includes primary secondary tertiary interventions continuous sun protection early childhood onward important avoid extrinsic skin damage skin cancer exposure irritants allergens molecules damaging skin must avoided reduced minimum public health approaches needed implement preventive basic skin care worldwide reach high numbers dermatological patients care receivers education primary caregivers implementation community dermatology successful strategies resource poor countries besides specialist physicians nurses health care professionals play important roles preventing managing age related skin conditions developing well developed countries healthy skin across life course leads better mental emotional health positive impact social engagement healthier active productive lives
existing methods measuring loop gain digitally controlled converters mainly fall two categories namely analog signal disturbance method asdm digital signal disturbance method dsdm however loop gains obtained methods totally agree rigorous theoretical analysis paper derived expressions open loop gains obtained two methods whose accuracy verified simulation also paper put forward difference signal enters sampler results variation transfer function sampler induces difference open loop gains obtained asdm dsdm
resilience defined ability overcome adverse situations sport severity injury cause individual collective problems ability cope injury depends ability resilience aim study analyze relationships resilience sports injuries function competitive level research data athletes practicing football handball winter sports ski snowboard analyzed using risc questionnaire checklist injuries competitive level descriptive relational analysis carried results show athletes injured last three seasons competed higher levels greater capacity resilience given data could conclude competitive level directly affects ability cope injuries athletes suffered injuries used deal however due differences found clear resilience depends individual factors
electrical energy normally generated different sources hydroelectric wind heat nuclear transformation chemical reactions vibrations nowadays harvesting power mechanical vibration one novel technologies usually done systems based electromagnetic electrostatic piezoelectric combination piezoelectric systems convert motion vibrating structures electrical power cellulose electro active paper eapap recognized novel smart piezoelectric material used energy harvesting purposes one prevalent method vibration energy harvesting using unimorph piezoelectric cantilever beams paper analytical solution based distributed parameter model presented calculate generated energy vibration cantilever substrate partially covered eapap material studied structure piezoelectric layer thickness comparison length beam thickness substrate material considered thin thus effect vibration behavior structure negligible results validated experimental values analytical data found close experimental results finite element simulation values findings study provide guidelines system parameters manipulated efficient performance different ambient source conditions
background suppurative otitis media som major public health concern worldwide associated increased morbidity cases fungal suppurative otitis media studied establish effect fungi otitis media methods ear swabs patients collected aseptically using sterile cotton swabs discharging ear perforated tympanic membrane swabs subjected microscopic culture investigations species fungal growing sabouraud agar identified using maldi tof moulds broth micro dilution method following eucast guidelines employed determine susceptibility patterns itraconazole voriconazole posaconazole results total cases positive fungal culture growth studied median age patients fungal infection iqr years patients pure growth one type fungal candida albicans common fungus isolated followed aspergillus versicolor total patients disease complication time enrollment hearing loss follow poor treatment outcome five aspergillus fumigatus strains resistant itraconazole reduced susceptibility voriconazole posaconazole carried carrying resistance allele addition penicillium citrinum isolates resistant voriconazole penicillium sumatrense resistant itraconazole voriconazole non significant association poor treatment outcome female gender hiv positive infected moulds conclusion fungal infections play significant role som pathology setting diagnosis fungal infections developing countries improved appropriate management initiated time prevent associated complications
objective determine efficacy psychotherapy interventions reducing suicidal attempts non suicidal self injury nssi methods meta analysis randomized controlled trials rcts comparing psychotherapy interventions treatment usual tau including also enhanced usual care psychotropic treatment alone cognitive remediation short term problem oriented approach supportive relationship treatment community treatment non behavioral psychotherapy experts emergency care enhanced provider education treatment nssi rcts extracted medline embase psycinfo cochrane library analyzed using cochrane collaboration review manager software comprehensive meta analysis results included rcts patients randomly assigned receive psychotherapy tau patients received psychotherapy less likely attempt suicide follow pooled risk difference confidence intervals absolute risk reduction psychotherapy tau yielding estimated number needed treat sensitivity analyses showed psychotherapy effective mainly adults outpatients patients borderline personality disorder previously non previously suicidal patients heterogeneous variable included past history nssi deliberate self harm imminent suicidal risk suicidal ideation long short term therapies tau control condition mentalization based treatment mbt evidence efficacy found nssi exception mbt study heterogeneity publication bias detected presence publication bias duval tweedie trim fill method applied conclusion psychotherapy seems effective treatment however trials lower risk bias homogeneous outcome measures longer follow needed elsevier ltd rights reserved
aims objectives identify factors associated anxiety depression patients implantable cardioverter defibrillators background implantable cardioverter defibrillator effective increase survival life threatening arrhythmias lowers health related quality life anxiety depression significant negative association health related quality life however knowledge factors associated two negative emotions specific population inadequate design cross sectional descriptive design conducted secondary analysis performed address aim methods convenience sampling patients implantable cardioverter defibrillators performed anxiety depression measured hospital anxiety depression scale face face interview results stepwise multivariable regression results showed older age aged aged self care dependent perceive higher depression nursing strategies suggested reduce depression especially older people self care dependent early screening essential provide immediate care reducing vulnerabilities arising depression performing comprehensive assessment selfcare ability providing adequate assistance crucial family involvement may reduce depression providing physical psychosocial support
work reported focuses controllability expressions mathematical modeling dehydration process food concentrates producing powder using spray dic spray detente instantanee controlee spray instant controlled pressure drop paper presents second order partial differential equations mathematical modeling moisture heat transfer spray dic process paper proposes enhancement simple model dic technique controllability expression used spray dic controllability expression drying process models gives better results compared models without controllability expression results computed shown matlab windows operating systems controllability expression dehydration process model using spray dic drier manage succesfully control dehydration process
background various sources indicate mental disorders leading contributor burden disease among youth important determinant functioning current mental health status study investigated whether psychiatric history additional predictive power predicting individual differences functional outcomes method used data dutch trails study youths followed pre adolescence young adulthood retention youths successfully interviewed age using world health organization composite international diagnostic interview cidi assess current past cidi dsm mental disorders four outcome domains assessed time economic academic achievement social benefits financial difficulties social early motherhood interpersonal conflicts antisocial behavior psychological suicidality subjective well loneliness health behavior smoking problematic alcohol cannabis use results outcomes predicted current past disorders three past disorders receiving social benefits psychiatric hospitalization adolescent motherhood two current disorder absenteeism obesity type disorders important depended outcome adjusted current disorder past internalizing disorders predicted particular psychological outcomes externalizing disorders predicted particular health behavior outcomes economic social outcomes predicted history morbidity internalizing externalizing disorder risk problematic cannabis use alcohol consumption dropped history internalizing disorder conclusion understand current functioning necessary examine current past psychiatric status
impaired insulin signaling recognized common pathogenetic mechanism diabetes alzheimer disease progression brain characterized defective insulin receptor substrate irs increased oxidative stress thymol monoterpene phenol isolated medicinal herbs exhibited robust neuroprotective effects present study designed investigate protective effect thymol hfd induced cognitive deficits explore possible mechanisms cbl mice fed weeks either hfd normal diet mice fed hfd dosed metformin thymol daily observed thymol treatment significantly reversed gain body weight peripheral insulin resistance induced hfd meanwhile thymol improved cognitive impairments morris water maze mwm test decreased hfd induced beta deposition tau hyperphosphorylation hippocampus may correlated inhibition hippocampal oxidative stress inflammation addition thymol regulated level ser irs hence enhancing expression ser akt ser gsk beta found protective effects thymol cognitive impairments associated regulation nuclear respiratory factor nrf heme oxygenase pathway conclusion thymol exhibited beneficial effects hfd induced cognitive deficits improving hippocampal insulin resistance activating nrf signaling
transcranial magnetic stimulation devices used mainly diagnostic purposes measuring functions nervous system rather treatment purposes problem considerable energy fluctuations per repeated pulse majority strokes caused ischemia result brain tissue damage leading problems central nervous system including hemiparesis dysfunction language consciousness dysfunction perception control difficult size large due difficulty digitalizing energy stored capacitor many heavy devices addition many constraints used range purposes head neck diagnosis treatment rehabilitation nerve palsy muscle strengthening treatment urinary incontinence etc output stabilization minimization energy variation rate required level transcranial magnetic stimulation device dramatically improved demand therapeutic purposes increases study developed compact low cost transcranial magnetic stimulation device minimal energy variation high repeated pulse output stabilization using real time capacitor charge discharge voltage ischemia induced male rats closing common carotid artery minutes blood perfused cerebrum number parp reactive cells hours significantly decreased tms group compared group result tms showed greatest effect necrosis related parp immuno reactive cells hours ischemia indicating necrosis inhibition blocking neural cell death protection neural cells
purpose purpose paper test feasibility implementing healthy lifestyles intervention maintain achieve healthy weight low income young adults vocational education design methodology approach non randomized quasi experimental feasibility test ten week intervention follow assessment designed using precede proceed convenience sample included low income young adults years recruited two vocational training facilities intervention weekly online educational modules targeting non dieting approach healthful eating physical activity messages promote fruit vegetable intake increased physical activity stress management anthropometrics measured online survey physical activity eating behavior self regulation self instruction emotional eating administered baseline post follow findings baseline males overweight females obese based average bmi significant change bmi food intake physical activity stress management noted following intervention eating behavior changed treatment control group food self regulation higher high use treatment group compared control group practical implications lifestyle interventions critical low income young adults overweight obese years age young adults engage interventions make food behavior changes mediating effect healthy weight management models like precede proceed vital success working toward sustainable programs within communities originality value healthy lifestyle programs reported low income non college young adults specifically largely male population none precede proceed
simple fast sensitive accurate methodology based lle followed liquid chromatography tandem mass spectrometry simultaneous determination four regioisomers iso prostaglandin alpha iso prostaglandin alpha beta prostaglandin alpha prostaglandin alpha routine analysis human plasma samples developed isoprostanes stable products arachidonic acid peroxidation regarded reliable markers oxidative stress vivo validation method performed evaluation key analytical parameters matrix effect analytical curve trueness precision limits detection limits quantification homoscedasticity met analytical data weighted linear regression applied order improve accuracy lower end points calibration curve detection limits lods ranged plasma samples spiked isoprostanes level intra interday repeatability ranged respectively applicability proposed approach verified monitoring isoprostane isomers level plasma samples collected young patients subjected hyperbaric hyperoxia oxygen kpa min multiplace hyperbaric chamber elsevier rights reserved
heart healthy fortified functional foods extremely successful recent years commonly fortified foods yoghurt bread milk spreadable oils fats widely used functional ingredients products plant sterols stanols omega fatty acids bio active peptides niche ingredients soluble fibre squalene antioxidants also becoming increasingly visible estimated heart health related products launched globally year global sales heart healthy fortified functional oils yoghurts milk breads reached eur billion western europe accounting percent sales eur billion cardiovascular disease leading cause death europe accounting percent deaths surprise heart healthy fortified functional foods faring well third terms sales fortified functional foods western europe following closely behind digestive health immune support despite challenges facing market products questions credibility price conscious consumers expected continue impressive performance new brands product formats health claims likely emerge
direct connect topology etc torus hasbeen pervasive high performance computing hpc platforms also appearing datacenters paper discusses prospects challenges using direct connect topology hpcs datacenters proposes new hybrid optical electrical switching architecture solve major challenges high end end latencies multi hop routing developed openflow based software defined networking testbed control electrical optical switching components network architecture conducted experiments verify networking performance hybrid optical electrical direct connect network experimental results show hybrid architecture indeed reduce network diameter therefore end end latency applications require communications mapreduce greatly benefit reduced network diameter end end latency
main conclusion evidence shows decreasing light harvesting antenna size photosystems tobacco helps increase photosynthetic productivity plant canopy biomass accumulation high density cultivation conditions decreasing truncating chlorophyll antenna size photosystems theoretically improve photosynthetic solar energy conversion efficiency productivity mass cultures algae plants threefold truncated light harvesting chlorophyll antenna size tla classes photosynthetic organisms would help alleviate excess absorption sunlight ensuing wasteful non photochemical dissipation excitation energy thus solar biomass energy conversion efficiency photosynthetic productivity high density cultures increased applicability tla concept previously shown green microalgae cyanobacteria yet demonstrated crop plants work tla concept applied high density tobacco canopies work showed improvement stem leaf biomass accumulation tla tobacco canopies measured wild type counterparts grown ambient conditions distinct canopy appearance differences described tla wild type tobacco plants findings discussed terms concept application crop plants leading significant improvements agronomy agricultural productivity application photosynthesis generation commodity products crop leaves
constant rail rail operational amplifier circuit topology presented paper amplifier input stage realized using single nmos pair bulk cmos process technology overall gain variation within range rail rail common mode input range proposed design able reject common mode input response common mode rejection ratio cmrr high slew rate achieved simulated value unity gain buffer amp variation overall gain also simulated different corner temperatures circuit simulation done tanner eda power supply dissipates power
aims study explore empirical clusters sample individuals gambling disorder according presence illegal behaviors describe subgroups clinical level examine whether temporal change taken place across last years sample consisted patients consecutively received outpatient treatment reported presence dsm criteria presence illegal behavior two step clustering procedure revealed existence four empirical groups differed sociodemographic clinical profiles patients committed illegal acts due gambling behavior heterogeneous group possible identify different subtypes based sociodemographic psychopathological clinical personality characteristics
association erectile dysfunction cardiovascular disease long recognized studies suggest erectile dysfunction independent marker cardiovascular disease risk therefore assessment management erectile dysfunction may help identify reduce risk future cardiovascular events particularly younger men initial erectile dysfunction evaluation distinguish predominantly vasculogenic erectile dysfunction erectile dysfunction etiologies men believed predominantly vasculogenic erectile dysfunction recommend initial cardiovascular risk stratification based framingham risk score management men erectile dysfunction low risk cardiovascular disease focus risk factor control men high risk including cardiovascular symptoms referred cardiologist intermediate risk men undergo noninvasive evaluation subclinical atherosclerosis growing body evidence supports use emerging prognostic markers understand cardiovascular risk men erectile dysfunction markers prospectively evaluated population conclusion support cardiovascular risk stratification risk factor management men vasculogenic erectile dysfunction elsevier inc rights reserved
cdk cyclin dependent kinase family member global orchestrator neuronal cytoskeletal dynamics embryogenesis cdk indispensable brain development adults essential numerous neuronal processes including higher cognitive functions learning memory formation drug addiction pain signaling long term behavior changes long term potentiation long term depression rely rapid alterations cytoskeleton cdk activity becomes deregulated various brain disorders including alzheimer disease parkinson disease huntington disease attention deficit hyperactivity disorder epilepsy schizophrenia ischemic stroke result profound remodeling neuronal cytoskeleton commentary specifically focuses pleiotropic contribution cdk regulating neuronal microtubule remodeling vast majority physiological substrates cdk associated neuronal cytoskeleton emphasis cdk substrates crmp stathmin drebrin dixdc axin map mapb doublecortin kinesin tau allowed unravel molecular mechanisms cdk exerts divergent roles regulating neuronal microtubule dynamics healthy disease states
robotic manipulators widely used many arenas robotic arm performs positioning traditional controller pid controller problem able compensate payload variations end effector robotic arm grasps different payload masses applications require output joint motion vary decreases end effector positioning accuracy robotic arm system based model reference control approach payload variation effect solved effectively therefore improve robotic arm positioning accuracy performance
new data encryption scheme proposed based position substitution shuffling diffusion process algorithm searches position text symbol randomly generated matrix subsequently replaces symbol positions matrix shuffled retraceable manner depending upon encryption key substituted positions diffused cipher text get affected even single symbol changed system uses logistic map matrix generation position shuffling algorithm also checks integrity cipher text including parity encrypted form system includes substitution permutation diffusion high level cryptographic complexity achieved cipher text proposed method key sensitive output cipher text random nature avalanche effect key length chosen sufficient resist brute force attack cryptographic model whole demonstrate remarkable resistance statistical attacks key feature detailed runtime comparison different known cryptographic systems given elsevier ltd rights reserved
life many people vital social activities depend good functioning civil structures nuclear power plants large bridges pipelines others especially high winds earthquakes environmental changes recognize structural damage existing systems signals stiffness reductions components changes observed displacements certain load environmental conditions formulated inverse problem solved learning approach using neural networks network function referred associative memory device capable satisfactory diagnostics even presence noisy incomplete measurements new idea however obtain real time advanced warning onset durability structural problems stage preventative action possible emerged creating exciting new field within civil engineering refers broad concept assessing ongoing service performance structures using variety measurement techniques global position system real time kinematic gps rtk wireless sensor networks wsn others leads case called big data big data term applied data sets whose size beyond ability commonly used traditional computer software hardware undertake acquisition access analytics reasonable amount time solve problem use hadoop like batch processing system using distributed parallel processing paradigm called mapreduce like system handles volume variety part big data mapreduce programming model google associated implementation processing generating large data sets using group machines despite continuous data bigdata originated gps rtk wsn studied paper one selected data used determine technical state structure real time however bigdata approach used paper solve following problems firstly small number available data neural network training may lead strange practical solutions beyond permissible area overcome problem small available data supplemented numerical data generated integration monte carlo simulation finite element method mcsfem model also learning approach using neural networks gives effect guaranteed network among various required conditions complete set training data good optimal architecture integration monte carlo simulation mcsnn model order find optimal global architecture selected formulated solve problem mcsfem model mcsnn model require expensive computing lead necessity use parallel computing based multi processorsystem chip mpsoc architecture secondly use mpsoc architecture led emergence multiple named net neural network nonn rather single simple approach trial error single neural network insufficient determine optimal architecture nonn deal problem develop paper new distributed parallel processing using master slaver structure mapreduce framework rather google hadoop like batch processing system using distributed parallel processing paradigm called mapreduce method based single instruction multiple data simd technology using computer multiprocessor systems chip computer multiple cores cpus without necessarily google computer program group machines used mcsfem model mcsnn model order generate virtual dataset find optimal architecture nonn enables create quickly many numerical data eighty thousand architectures using computer eight cpus created instead eight thousand using computer one cpu computation times effect obtained presented numerical example local damage detection real time plane steel truss structures one react quickly problems appear predict new trends near future
introduction hereditary angioedema inhibitor deficiency inh hae rare disease characterized recurrent unpredictable episodes cutaneous mucosal edema bradykinin released activation contact system binds bradykinin receptors endothelial cell surface enhance vascular permeaility leads angioedema areas covered inh hae therapy aimed inhibition bradykinin release well blockage effects mediated receptor three controlled trials three open label extensions two open label studies prospective observational study confirmed safety efficacy bradykinin receptor antagonist icatibant administered acute treatment hae attacks adult patients inh hae expert commentary ready use pre filled syringes icatibant self administered easily effectively safely importantly conviently resulted patients able quickly treat attack realize dramatic change better lives
microbial electrochemical systems mess attracting technology disposal wastewater treatment simultaneous energy production mess anode microorganisms catalytic activity generates electrons converted electricity valuable chemical compounds microorganisms ability donate accept electrons anode cathode electrodes respectively recognized exoelectrogens mess renders important function performance present mini review discussed role microbiome including pure culture enriched culture mixed culture different bess application effects operational biological factors microbiome development discussed discussion molecular techniques evaluation microbial community analysis addressed addition different electrochemical techniques extracellular electron transfer eet mechanism electroactive biofilms discussed review highlights importance microbiome development mess effective operational factors exo electrogens activities well key challenges future technological aspects also briefly discussed elsevier ltd rights reserved
introduction philadelphia negative myeloproliferative neoplasms mpn characterized overproduction one blood cell lines methods studied proliferative characteristics patients novo mpn colony forming cells cfc endogenous colonies bone marrow peripheral blood analyzed colony assay based methylcellulose level circulating cells determined flow cytometry results total number cfc primary myelofibrosis pmf increased compared control sample essential thrombocythemia highest number observed polycythemia vera increased levels cells characterized early prefibrotic advanced fibrotic pmf compared whole mpn group total number cfc cells correlated degree fibrosis higher levels circulating cells pmf correlated total number degree fibrosis conclusions exploration proliferative characteristics mpn diagnosis may helpful revealing early prefibrotic pmf monitoring levels circulating cells may provide sensitive indicator fibrotic evolution pmf
study aimed develop ecofriendly bio photocatalyst arsenic abatement aqueous phase nano tio feldspar embedded chitosan composite developed immobilizing nano sized tio feldspar fine particles matrix chitosan characterized via fourier transform infrared spectrometry ftir ray diffraction xrd scanning electron microscopy sem coupled energy dispersive spectroscopy edx brunauer emmett teller bet surface area analyses batch adsorption experiments equipped illumination set conducted study operational parameters solution light existing ions along kinetics isotherm thermodynamics process unlike tio based remediation techniques synthesized composite effectively removed arsenic wide range slight removal drop increasing arsenate negligible influence arsenite removal showed selective removal arsenate presence existing ions including fluoride sulfate yet phosphate indicated somewhat competing effect existed higher concentrations isotherm kinetics adsorption investigated linear nonlinear modeling sips isotherm pseudo second order kinetic models best fitted experimental data langmuir maximum adsorption capacities via linear nonlinear modeling found respectively adsorption photocatalysis system exposure resulted higher removal arsenate arsenite irradiation enhanced removal efficiencies arsenate arsenite respectively temperature studies revealed thermodynamically spontaneous favorable process identified characterization analyses functional groups chitosan structure including along metal oxide contents bio photocatalyst introduced adsorptive photoactive sites elsevier rights reserved
sleep problems common patients systemic lupus erythematosus sle study aimed examine following predictors sleep quality fluctuations sleep quality patients sle patients sle recruited three rheumatology centers japan collected demographic clinical data data sleep quality measured pittsburgh sleep quality index psqi medical outcome study short form lupus patient reported outcome tool lupuspro fluctuations sleep quality examined administering psqi second time week interval used multiple linear regression analysis predict sleep quality patients completed survey showed poor sleep quality largest fluctuation sleep quality waking middle night early morning lupuspro pain vitality major predictor poor sleep significant predictors mostly lupuspro subscales clinical variables subscales mostly non predictive majority participants poor sleep quality lupus specific qol scale important understanding poor sleep quality sle patients symptom management appeared play key role improving sleep quality
two studies examine relationship naturally occurring levels circulating testosterone empathic accuracy study authors find higher endogenous levels testosterone negatively related accuracy people infer thoughts feelings others study authors use data collected field show individuals higher levels endogenous testosterone evaluated real world professional colleagues functioning lower levels empathic accuracy furthermore authors report evidence negative relationship testosterone perceived empathic accuracy downstream consequences perceptions one leadership skills abilities
letter discusses failure lorentz force law locate recoil action railguns ampere force law makes predictions agree experiment
purpose perianal fistulous disease present children crohn disease frequently complex refractory treatment one third patients recurrent lesions conducted systematic review literature examine best surgical strategy strategies pediatric complex perianal fistulous disease cpfd methods searched central medline embase cinahl studies discussing least one surgical strategy treatment pediatric cpfd reference lists included studies hand searched two researchers screened studies inclusion quality assessed relevant study extracted data resutls one non randomized prospective two retrospective studies met inclusion criteria combined use setons infliximab therapy shows promise first line treatment specific form fistulectomy cone like resection also shows promise combined biologics endoscopic ultrasound guide medical surgical management feasible pediatric population though unclear improves outcomes conclusions paucity evidence regarding treatment cpfd pediatric population research required recommendations made surgical management optimal
organic mitral regurgitation common disorder increase population aging occurrence steadily increasing current guideline recommendations management asymptomatic severe conflicting based solely registries nonrandomized trials expert heart valve clinics resulting lack evidence best treatment strategy review evaluate latest evidence diagnostic approaches treatment strategies asymptomatic patients without clear indication surgical intervention implications management daily practice discussed including update diagnostic approaches currently available evaluation optimal care important every severe patient including unidentified patient referred specialized heart team assessed individual basis according guideline recommendations experience surgical center patient characteristics preferences screening diagnostic approaches need performed basis standardized protocols strict criteria addition specialized valve centers must meet surgical criteria guarantee high reparability rates asymptomatic patients awareness among cardiologists cardiothoracic surgeons improved guidelines adherence systematic approach including strict criteria management asymptomatic patients severe organic ensure reliable applicable results research daily clinical practice
using synchrotron ray scattering investigate liquid gete spanning wide temperature range near melt demonstrate density anomaly fragile strong transition related short range order sro structural change peierls like distortion also accompanied remarkable development medium range order mro latter manifests emerging pre peak total structure factor atomic pair correlations length scale similar angstrom real space function results highlight role medium range structural ordering evolution configurational entropy according adam gibbs theory linked fragile strong transition transition based relation structure liquid dynamics transitions high pressures examined terms experimental data ehrenfest relation work identifies length scale atomic correlations mro structural evolutions presents structural approach exploring liquid dynamics may useful investigating relevant phase change alloys acta materialia inc published elsevier ltd rights reserved
increasing global environmental awareness evidenced recent worldwide calls control climate change greenhouse emissions placed significant new technical mandates automotives improve engine efficiency directly related production carbon dioxide major greenhouse gas reduction parasitic losses vehicle powertrain engine systems key component energy conservation engine efficiency improvement various approaches include improvements advanced combustion systems component system design handling sizing boosting electrification well waste heat recovery systems etc among approaches engine friction reduction key relatively cost effective approach receiving significant attention tribologists lubricant lubrication engineers alike paper fundamentals friction specific environments engine components tribology reviewed together discussions impact developing vehicle powertrain technologies surface material technologies well lubricant additive technologies promises continuing friction wear reduction trends international accords climate change require gains fuel efficiency energy sustainability industry sectors including automotive broader internal combustion engine industries latter encompass highway power generation marine rail industries well paper focsuses friction reduction mainly automotive engines however paper starts clarification common descriptors mechanical losses friction engine followed topic lubrication fundamentals lubrication regimes lubrication contacting surfaces major engine subsystems discussed turn subsystems include piston assembly ring pack liner piston skirt liner piston pin connecting rod contacts connecting rod crankshaft bearings valvetrain subsystem relative contributions total friction various subsystems discussed piston assembly contributing half total friction remainder friction comes crankshaft connecting rod camshaft bearings valvetrain oscillating parts bearings predominantly hydrodynamic lubrication contrast valvetrain oscillating components characterized mostly mixed boundary lubrication regimes despite title paper section emerging powertrain technologies including combustion gasoline diesel engines also given context trend towards clean efficient propulsion systems impact developing technologies reduction friction parasitic losses via component material lubricant deisgn discussed technologies include gasoline direct injection gdi turbocharged hybrid vehicles generate unique green environmental opportunities future propulsion systems technologies critical meet fuel economy reduced emission targets specifically paper address impact emerging technologies future lubricant requirements advanced tribology research connection lubricant tribological requirements beillustrated briefly describing basic lubrication friction processes major engine components incorporating emerging technologies lastly besides new hardware material science changes several advanced additives advanced friction modifiers antiwear additive chemistries low viscosity lubricants introduction new improvers represent possible tribological solutions challenge meeting stringent energy efficiency requirements environmental legislation original equipment manufacturers oems seek accomplish goals hardware emission system changes place new demands even greater stress engine oils time engine durability performance reliability primary importance vehicle owners operators final section paper discuss future trends engine friction reduction wear control surface modification friction reducing coatings surface textures engine components impact surface coatings surface textures engine friction reviewed addition oems lubricant formulation manufacturers need respond novel engine oil technologies formulated protect engine keeping emissions system working optimal fuel economy retaining engine durability brief paper reviews characteristics component friction environment internal combustion engine relevant design considerations addresses impact emerging technologies engine friction tribological changes requirements especially lubricant additives lastly iii discusses interactions lubricant additive formulations material surface engineering effects friction wear engine durability increasing importance interplay synergistic advancements component design material surface engineering advanced lubricant additive formulation fully illustrated
objective review pharmacokinetics safety drug drug interactions advantages disadvantages currently available single tablet regimens strs hiv infection data sources search using pubmed conducted september using following keywords single tablet regimen hiv additionally pubmed search conducted individual str using generic names agents articles evaluated content additional references identified review literature citations study selection data extraction studies included predominantly phase iii clinical trials exception tenofovir alafenamide phase phase trials also relevant new antiretroviral agent data synthesis six strs currently available treatment hiv agent unique pharmacokinetic safety drug drug interaction profiles result distinct advantages disadvantages three agents first line recommended therapies per national guidelines high virological efficacy tolerability conclusions strs significantly advanced hiv management minimizing pill burden improving patient compliance important consider nuances str regard renal hepatic function drug interactions tolerability ensure safe effective use
attitudes toward intimate partner violence ipv affect prevalence ipv response victims ipv whether seek help response professionals police social workers health care professionals ipv knowledge ipv related attitudes essential developing effective social work violence related programs using data multiple indicator cluster surveys study examines attitudes toward ipv socio demographic predictors attitudes among married women kazakhstan kyrgyzstan tajikistan women asked whether approved husband beating wife goes without telling neglects children argues refuses sex burns food prevalence ipv acceptance least one five reasons varied kazakhstan kyrgyzstan tajikistan women less educated members asian ethnic groups resided middle class urban areas lived specific regions likely accept ipv age differences emerged indicated young women approving ipv proactive efforts needed confront attitudes gender roles ipv tajikistan kyrgyzstan
availability visual sensors increment processing capabilities led development new generation multi camera systems increment also conveyed new expectations requirements fulfilled applying traditional fusion techniques ultimate objective computer vision systems obtain description observed scenario terms computable human readable seen specific form situation assessment particularly great interest human activity recognition several areas surveillance ambient intelligence simple activities recognized applying pattern recognition algorithms sensor data however identification complex activities requires development cognitive capabilities close human understanding several recent proposals combine numerical techniques symbolic model represents context dependent background common sense knowledge relevant task chapter current challenges development vision based activity recognition systems described tackled exploiting formally represented context knowledge along review related literature describe approach examples areas ambient intelligence indoor security chapter surveys methods context management literature use symbolic knowledge models represent reason context due relevance pay special attention ontology logic based models
turbo expanders used energy conversion many fields sometimes operated partial admission mode depending stability energy source solar energy waste thermal energy fluctuate depending environmental process condition ability operate partial admission advantageous allows continuous operation without interchanging components however method also leads lower turbo expander efficiency experimental study conducted investigate losses various partial admission rates addition effect tip clearance studied since another important parameter affecting turbo expander performance linear cascade fabricated nozzle set based axial direction blade row designed movable along pitchwise direction order investigate flow characteristics function blade movement flow structures pressure losses measured various partial admission rates tip clearances experiment conducted reynolds number based chord experimental results showed losses passages depended partial admission rate also location relative nozzle elsevier ltd rights reserved
introduction two thirds people living hiv plwh show sub optimal adherence antiretroviral therapy art one third engages risky sex non adherence risky sex associated emotional distress impulsivity allay distress lessen impulsivity mindfulness training helpful trial investigate utility phone delivered pwlh primary outcomes comprise feasibility acceptability phone delivery secondary outcomes estimates efficacy adherence art safer sexual practices well hypothesized antecedents methods design fifty participants enrolled parallel group randomized clinical trial rct outpatients recruited hiv treatment clinic randomized ratio either attention control intervention interventions administered weekly phone calls art adherence self reported measure unannounced phone pill counts sexual behavior self reports biomarkers mindfulness depression stress impulsivity measured baseline post intervention months post intervention conclusions great potential help plwh manage stress depressive symptoms impulsivity positive changes antecedents expected improve safer sex practices art adherence results exploratory trial support hypotheses conduct large rct test efficacy art adherence safer sex practices hypothesis improved art adherence safer sex reduce viral load decrease incidence sexually transmitted infections respectively elsevier inc rights reserved
concept genitourinary syndrome menopause gsm recently introduced gaining widespread use justifications introduction straightforward others may questionable numerous unspecific symptoms signs included definition syndrome minimum number required diagnosis established gsm definition designed facilitate identifying vulvovaginal urinary estrogen deprivation associated symptoms signs several concerns evolved syndrome may result underdiagnosis vulvar urinary pathology serious conditions high grade squamous intraepithelial lesions vulva vulvar intraepithelial neoplasia differentiated type may missed others may receive appropriate treatment lichen sclerosus overactive bladder addition transformation urogenital symptoms signs syndrome may create iatrogenization menopause consequently lead demand offer panacea treatments detrimental care women require focused therapy rather global treatment addressing variety genitourinary conditions even require form intervention women needs may better served precise urogenital diagnosis
background adverse childhood experiences aces associated increased risk variety diseases including cancer however research largely ignored aces impact cancer screening potential intermediate outcome present study examined association aces ever recent use papanicolaou pap test among women aged older materials methods analyses used tennessee behavioral risk factor surveillance system model odds ever recently within last years engaging pap tests screening nine different adversities bivariate multivariate logistic regression models run accomplish results bivariate multivariate models living household adults treated violently increased odds ever receiving pap test bivariate models physical sexual abuse associated decreased odds receiving recent pap test accounting confounders latter association remained significant conclusions results highlight potential mechanism early childhood experiences impact development cervical cancer providers care consider modifications screening practices including screening child abuse better serve women
green building inevitable trend construction industry deeply affects social development economy environment series industries practical significance multidimensionally balanced development green buildings model multi objective assessment green building developed three dimensions objective professional time opt according green building definition opt coordinate system built based scoring centroid system china green building labelling scheme gbl singapore green mark introduction coefficient variation moment inertia frameworks restructured based case study practical project chongqing achieved highest gbl awards results show gbl distributes scores evenly concentrates energy saving greater diversity land supply building operations normalized coefficients variation project compliance coefficients gbl respectively indicating higher degree compliance framework developed model provides multitarget oriented guidelines green building design assessment standard development elsevier rights reserved
recent years development composite nanostructures containing noble metal magnetic nanocrystals attracted much interest offer promising avenue multifunctional applications nanomedicine pharmacotherapy work present facile two step hydrothermal approach synthesis bifunctional heterodimer nanoparticles hdnps composed hematite nanocubes alpha feo ncs silver nanoparticles nps formation magnetic property alpha feo hdnps analyzed transmission electron microscopy ray diffraction vibrating sample magnetometer interestingly hydrothermal synthesized alpha feo hdnps found display significant antibacterial activity three types infectious bacteria cytotoxicity alpha feo nanocomposite lung cancer cell line investigated compared pure alpha feo ncs nps obtained results reveal alpha feo nanocomposite exhibited higher anticancer performance pure nps whereas pure alpha feo ncs cytotoxic tested cells inhibitory concentration alpha feo nanocomposite found aforementioned properties alpha feo hdnps showed high potential multifunctional material advanced biomedicine nanotherapy applications
background aimsalterations gut microbiota assumed etiology pathogenesis irritable bowel syndrome ibs studies however alterations gut microbiota ibs patients systematically assessed meta analysis performed mate analysis explore compare alterations gut microbiota ibs patients china regions around world methodscase control studies detecting gut microbiota ibs patients identified english chinese databases standardized mean difference smd confidence interval bacterial counts calculated resultsten studies china seven studies regions around world included study compared healthy controls smds bifidobacteria lactobacillus escherichia coli enterobacter chinese ibs patients respectively smds bacteroides enterococcus found significant differences chinese ibs patients however smds bifidobacteria bacteroides ibs patients regions smds lactobacillus coli enterobacter enterococcus found significant differences conclusionsthere alterations gut microbiota ibs patients implied alterations gut microbiota might involved pathogenesis ibs however species specific alterations gut microbiota different ibs patients china regions
introductionnatalizumab ntz effective drug treatment relapsing remitting multiple sclerosis patients discontinuation mandatory due risk progressive multifocal leukoencephalopathy however severe clinical radiological worsening described drug cessation aim describe clinical radiological features rebound phenomenon material methodspatients switched ntz fingolimod fty presented rebound discontinuation selected clinical magnetic resonance imaging mri data collected resultsfour virus positive patients included mean disease duration years mean time years ntz patients started fty within months neurological deterioration started mean time months multifocal involvement motor disturbances cognitive impairment seizures average worsening expanded disability status scale edss points mri showed large increase gadolinium enhanced lesions mean patients received days methylprednisolone one patient required plasma exchange patients presented neurological deterioration edss worsening points rebound three patients continued treatment fty one patient restarted ntz conclusiondiscontinuation ntz treatment may trigger severe rebound marked clinical radiological worsening careful evaluation benefit risk considered ntz withdrawal close monitoring short washout period recommended drug withdrawal
background little known regarding relationships among circulating brain derived neurotrophic factor bdnf levels glucose insulin children adolescents objective study investigate whether circulating bdnf levels would change oral glucose tolerance test ogtt methods performed ogtt measured serial changes bdnf levels plasma serum results subjects normal type group borderline diabetic type group defined results ogtt serum levels bdnf almost five times higher plasma levels gradually decreased ogtt whereas serum levels showed significant change reduction plasma bdnf level changes baseline min significantly different groups conclusions results showed plasma levels bdnf sensitive acute changes glucose insulin levels serum
problem invariance keys including simple keys investigated applied operations table algebras modern analogues classical relational codd algebras shown keys considered invariant respect operations intersection difference selection join division invariance hold simple keys keys including simple keys shown invariant respect renaming operation necessary sufficient conditions keys including simple keys invariant respect operations projection active supplement established results work theoretical practical interest used choose optimal keys designing relational databases
current era computer communication rapid development network security become one important factors consider security considerations wireless sensor networks wsns interesting point research especially fast spread wsns paper efficient two layer three layer intrusion detection models introduced two layer model represents levels sensor sink nodes three layer model represents levels sensor sink base station models elaborated examined set experiments supervised learning algorithm introduced used sensor node layer unsupervised learning algorithm introduced used layers learning algorithms used data training gave high detection accuracy used dataset using lesser number features compared approaches
introduction brain imaging fluorodeoxyglucose fdg positron emission tomography hexamethylpropyleneamine oxime hmpao spect widely used evaluation alzheimer dementia aim assess superiority one method methods twenty four patients clinical diagnosis alzheimer disease underwent fdg pet hmpao spect order assess zones hypo metabolism hypoperfusion specific alzheimer disease results fdg pet showed specific zones hypometabolism patients spect positive cases statistically significant difference conclusion fdg pet significantly superior hmpao spect fdg pet could replace classic role perfusion spect diagnosis alzheimer disease
purpose research develop game wind phoenix tales prometheus identify analyze actions players playing game solving puzzles facing immersion exploration universe investigated whether mathematical experiences emerged actions player way hypothesis game offers protagonist opportunities develop produce mathematical knowledge logical mathematical reasoning solving puzzles exploring spaces methodology adopted design based research since presents interactive interventionist approach allowed consideration theories presented production gameplay game embodied cognition deals concepts merleau ponty phenomenology reaches work barsalou barsalou fauconnier turner among others understand every action contextualized case experienced game logical mathematical reasoning indeed overcoming trial error process protagonists digital adventure developed processes problem solving creation conjectures data collection tests analysis indicating production strategic thinking concluded assuming role game players established enunciation process logical problems puzzles therefore development epistemological games revealed possibility start new paradigms production mathematical knowledge upon logical mathematical reasoning surpasses personal experiences elsevier rights reserved
increasing incidence dementia aging population consequently urgent need develop treatments activities may alleviate symptoms dementia accumulating evidence shows persons dementia enjoy music ability respond music potentially preserved even late severe stages dementia verbal communication may ceased media interest topic contributed public perception music abilities island preservation otherwise cognitively impaired person dementia chapter review current literature music cognition dementia show scarce rigorous scientific investigation issue various types music memory exist differentially impaired different types dementia furthermore discuss recent development music activities nonpharmacological treatment dementia highlight methodological limitations current literature topic reported music activities improve behavior particularly agitation mood cognition persons dementia recent large scale randomized control studies questioned specificity effect music found beneficial pleasant activities nevertheless music unique powerful ability elicit memories emotions provide important link individual past means nonverbal communication carers make ideal stimulus persons dementia
tropical soils major players emissions cycling earth however tropical countries scientists limited access analytical tools needed research processes paper describes construction test less chamber monitoring multiple soil gas emissions system consisted array three series gas sensors placed airtight container pic microcontroller custom built software developed data capture visualization running laptop modified multiplexing sensors also incorporated order allow parallel analysis eight samples chamber hereafter called senose short soil electric nose tested two separate experiments first study used three sensor array system soil samples colombia ecuador separated two groups order study gas emission patterns glucose induced respiration tests second experiment using multiplexed sensor array different set colombian soil samples gas emission patterns obtained autoclaved soil reduced microbial activity contaminated diesel oil source first study replicated continuous runs senose clearly showed differences soil respiration patterns soil samples prominent timing differential increase gas production spiking glucose proxy organic substrate results second study showed clearly different pattern gas emissions diesel oil contaminated samples microbial activity reduced soil autoclaving moreover two groups non autoclaved soil subsamples differing diesel oil addition could also differentiated basis respiration patterns hours gas tracking based results foresee great potential use low cost system fields soil microbiology fertility biotechnology environmental sciences processes microbial activity plant nutrient availability soil pollutant turnover tracked monitoring gas emission patterns elsevier rights reserved
novel series feruloyl donepezil hybrid compounds designed synthesized evaluated multitarget drug candidates treatment alzheimer disease vitro results revealed potent acetylcholinesterase ache inhibitory activity compounds showed moderate antioxidant properties compounds potent ache inhibitors highlighting addition three promising compounds exhibited significant vivo anti inflammatory activity mice paw edema pleurisy formalin induced hyperalgesy models vitro metal chelator activity neuroprotection human neuronal cells oxidative damage molecular docking studies corroborated vitro inhibitory mode interaction active compounds ache based data compound identified novel promising drug prototype candidate treatment innovative structural feature multitarget effects elsevier masson sas rights reserved
objective recent study identified survival benefit prophylactic neck dissection time primary surgery compared watchful waiting followed therapeutic neck dissection nodal relapse patients oral squamous cell carcinoma oscc alternative management neck cancer recommended minimize adverse effects indicating need sentinel node biopsy snb limited neck dissection conducted multicenter phase study examine feasibility snb clinically oscc methods previously untreated oscc patients clinical late tumors enrolled across institutions snb navigated multislice frozen section analysis sentinel nodes sns snb supported sentinel node lymphatic basin dissection basin dissection performed one stage procedure endpoint investigate rate false negative metastases basin dissection snb alone results tumors late lesions sns identified patients total sns detected among sns positive metastasis level level level iii level contralateral region neck false negative rate snb supported basin dissection snb alone respectively concordance status intraoperative frozen sections permanent histopathology sensitivity specificity intraoperative pathological evaluation respectively year overall survival disease free survival respectively negative patients significantly longer positive patients conclusion current study verified basin dissection useful back procedure snb performed one stage procedure showing low false negative rate snb alone appropriate staging method patients clinical staging reliable procedure determine appropriate levels neck dissection elsevier ireland ltd rights reserved
develop generalised unsteady plume theory compare new direct numerical simulation dns dataset ensemble statistically unsteady turbulent plumes theoretical framework described paper generalises previous models exposes several fundamental aspects physics unsteady plumes framework allows one understand structure governing integral equations depends assumptions one makes radial dependence longitudinal velocity turbulence pressure consequently ill posed models identified scase hewitt fluid mech vol shown result non physical assumption regarding velocity profile framework reveals ill posed unsteady plume models degenerate cases amongst comparatively large set well posed models derived generalised unsteady plume equations obtain drawing results dns plume subjected instantaneous step change source buoyancy flux use framework diagnostic capacity investigate properties resulting travelling wave general governing integral equations hyperbolic becoming parabolic limiting case top hat model travelling wave classified lazy pure forced according particular assumptions invoked close integral equations guided observations dns data use framework prognostic capacity develop relatively simple accurate well posed model unsteady plumes based assumption gaussian velocity profile analytical solution presented pure straight sided plume consistent key features observed dns
examine associations childhood sexual abuse csa substance abuse role mental health indicators mediators associations whether associations differ gender data respondents aged years canadian gender alcohol culture international study genacis multiple logistic regression models used examine associations csa substance abuse variables controlling socio demographic factors odds adjusted indicators mental health assess variables mediated associations csa substance abuse tests interactions sex csa conducted see gender differences exist associations csa reported women men csa associated heavy drinking hazardous drinking use marijuana illicit drugs label drugs associations marginally attenuated controlling depression self perceived emotional mental health cases previously observed significant associations persisted evidence gender differences associations csa substance abuse negligible preventing csa may also reduce substance abuse crown copyright published elsevier ltd
judo combat sport high risk injury present rare case traumatic left posterior sternoclavicular joint dislocation inflicted year old boy judo contest extensive literature review reveal case posterior joint dislocation judo patient treated closed reduction general anesthesia year follow left upper extremity full range motion complain residual symptoms decided discontinue judo training however participates physically demanding sports although often encountered posterior joint dislocation challenging critical medical problem fatal promptly diagnosed treated time considered differential diagnosis trauma related anterior chest pain
study objectives nocturia voids disturb sleep common cause awakenings associated daytime sleepiness standard treatments common causes nocturia relatively ineffective many treated patients nocturia left residual sleepiness carried pilot study evaluate potential armodafinil effective means addressing sleepiness persists many nocturia patients despite receiving standard therapy methods double blind placebo controlled crossover study carried patients nocturia receiving standard clinical therapy nocturia epworth sleepiness scale ess score least subjects received weeks armodafinil placebo order randomized results armodafinil led statistically significant improvement sleepiness compared placebo indicated ess primary outcome well clinical global impression improvement sleepiness scale key secondary outcome armodafinil increase nocturic events significantly increase adverse effects versus placebo conclusions pilot study first double blind placebo controlled trial assessing whether wake promoting therapy improve residual daytime sleepiness patients treated nocturia indicates promise armodafinil addressing residual sleepiness provides impetus carry large scale study definitively evaluate whether armodafinil effective therapy many patients nocturia experience daytime sleepiness persists despite receiving standard therapy condition
background type diabetes serious life long condition causes major health social economic burden children families community diabetes management involves strict adherence complex regimen poor management non adherence persistent problem among children parent child interactions parenting identified crucial points intervention support children health emotional well yet parenting interventions developed evaluated parents young children paper describes randomised controlled trial brief group based parenting intervention parents young children years type diabetes compared care usual cau methods design families randomised either positive parenting healthy living triple cau positive parenting healthy living triple involves group sessions outcomes assessed via parent child questionnaire home observations blood glucose monitoring baseline month months post intervention primary outcomes parent child reported parenting behaviour parent reported child behaviour adjustment parent reported child quality life secondary outcomes include parental self efficacy diabetes management illness specific general parenting stress parent reported child illness behaviour family quality life observed parenting child behaviour child illness control discussion theoretical background study hypotheses methods planned analyses discussed
one current challenges persimmon postharvest research development non destructive methods allow determination internal properties fruit maturity flesh firmness astringency study evaluates usefulness hyperspectral imaging range non destructive tool achieve aims persimmon rojo brillante astringent cultivar fruit harvested three different stages commercial maturity exposed different treatments degrees order obtain fruit different levels astringency partial least square pls based methods used classify persimmon fruits maturity predict flesh firmness average spectrum fruit results showed rate correct maturity classification firmness prediction five selected wavelengths astringency assessment results showed soluble tannins remain treatments distributed irregularly inside flesh model based pls built using spectrum every pixel fruit model obtained allowed creation predicted distribution maps tannins flesh fruit thereby pointing hyperspectral systems promising technology assess effectiveness deastringency treatments usually applied commercialising persimmons astringent cultivars elsevier rights reserved
next generation factory detector counterpart superkekb belle built japan upgrades kekb belle respectively new collider start commissioning ambitious project luminosity collider upgraded factor create times larger data set compared belle sample background triggered event rates increased factor least belle software system designed accommodate challenges run grid cloud local resources around world various external software packages employed enhance user interface software system basf structured framework built dynamic module loading ability parallel processing system written python steering scripts compatible common linux operating systems full detector simulation library created based geant paper explain design belle software structure current status software development
ipv provides address space improved address design greater security ipv different transition mechanisms used migrate ipv ipv includes dual stack networks tunnels translation technologies within network security essential element therefore requires special attention paper analyses two transition technologies dual stack tunnel technologies implemented using cisco packet tracer gns work also analyse security issues ipv outline common vulnerabilities security issues transition finally authors design implement dual stack automatic manual tunnelling transition mechanisms using riverbed modeler simulation tool analyse performance compare native ipv ipv networks
ependymal cells ciliated bcells confer unique pinwheel architecture ventricular surface subventricular zone svz cilia act sensors ventricular changes development aging several studies showed forebrain demyelination reactivates svz triggering proliferation ectopic migration oligodendrogenesis myelin repair potential role ciliated cells process investigated using conventional lateral wall whole mount preparation immunohistochemistry addition electron microscopy forebrain targeted model experimental autoimmune encephalomyelitis teae show early decrease numbers pinwheels cells cells changes transient simultaneous teae induced svz stem cell proliferation early drop cell numbers followed cell recovery cell division ependymal ribbon disruption never observed cells showed important morphological modifications reflected enlargement extended cytoskeleton reinforced cell cell junction complexes overtime possibly reflecting protective mechanisms ventricular insults finally teae disrupted motile cilia planar cell polarity cilia orientation ependymal cells therefore significant ventricular modifications ciliated cells occur early response teae suggesting role cells svz stem cell signalling development aging also inflammatory demyelination observations may major implications understanding pathophysiology designing therapeutic approaches inflammatory demyelinating diseases
paper introduced modal parameter based identification procedure identify equivalent system structures harmonic excitations developed identification technique assumed non proportional hysteretic damping equivalent system would applicable identifying general structures introducing quasi modal parameter modal analysis equation decoupled physical coordinate hence modal parameters vibration mode identified independently double iteration algorithm developed solve derived non linear identification equation complex unknowns developed identification procedure applied identify equivalent system numerical model order evaluate feasibility technique practice identification procedure also applied identify experimental mass bar rig validation purpose identification results showed identification procedure could identify accurately robustly equivalent system non proportional hysteretic damping assumption hence likely applicable field elsevier ltd rights reserved
arterial wall composite preferred orientation collagen fibers induces anisotropy though hyperelastic theories fiber reinforced composites reached high level sophistication showed reasonable correspondence available experimental data short failure description following tradition strength materials failure criteria usually separated stress analysis present work incorporate failure description hyperelastic models soft anisotropic materials introducing energy limiters strain energy functions limiters provide saturation value strain energy indicates maximum energy stored dissipated infinitesimal material volume using popular constitutive models enhanced energy limiters analyze rupture sheet arterial material plane stress state varying uniaxial equal biaxial tension calculate local failure criteria including maximum principal stress maximum principal stretch von mises stress strain energy moment sheet rupture find local failure criterion form critical strain energy robust among considered ones also find tensile strength maximum principal stress usually obtained uniaxial tension tests might appropriate failure indicator cases developed biaxiality stress strain state elsevier ltd rights reserved
use digital architecture pwm controllers point load pol applications together system identification techniques allows development fully automated routines situ system performance optimization controller parameters specifically tailored application context paper proposes method performing parametric system identification digitally controlled power converters using conventional analog frequency response analyzer fra nonlinearities intrinsic digital loop taken account thus leading accurate estimation converter parameters proposed method verified digitally controlled pol khz various bulk capacitor scenarios
objectivehealthy sleep important factor predicting longevity physical health well cognitive functioning study examined psychosocial factors contributing healthy sleep intention practice college students framework theory planned behaviour methodthis study used convenience sampling public university macao china students voluntarily filled questionnaires data obtained college students aged years serious sleep emotional disturbances path analysis used investigate whether data collected sample fit extended model theory planned behaviour including two additional variables namely parental nurturance perceived invulnerability resultsself reported healthy sleep patterns positively associated behavioural intention perceived behavioural control hypothesised positive direct effects attitude descriptive norm injunctive norm perceived behavioural control intention also observed resultant path model suggested parental nurturance perceived invulnerability exerted direct effects attitude norms perceived behavioural control conclusionthe results path analysis generally supported application theory planned behaviour understanding healthy sleep among college students university based health campaigns modify attitude descriptive norm injunctive norm perceived behavioural control effective promoting intention practice healthy sleep
end cold war brought many protracted internal conflicts wars lasted decades whose persistent instability lies heart chronic nation state regional instability responsibility chronically failed states attributed multiple unresolved root causes previous governance parties power longer trusted acceptable vacuum leadership many cases filled bad leadership concept piece argues number cases opportunistic leaders suffering severe antisocial character disorders emerged first saviors despots common criminals claiming patriots sharing psychological framework differs little responsible world war cold war followed describe identifying characteristics unique poorly understood subset population driven seek ultimate opportunity control dictate live fantasies power world scene discuss destructive actions remain unabated century continued antisocial presence influence levels violence must seen global security strategic issue amenable conventional diplomatic interventions negotiations mediations international sanctions
cell natural killer cell lymphomas relatively rare heterogeneous group diseases difficult treat usually poor outcomes date therapeutic interventions limited efficacy pressing need find better treatments recent years advances molecular biology helped elucidate underlying genetic complexity group diseases identify mutations signaling pathways involved lymphomagenesis review highlight unique biological characteristics different subtypes discuss may targeted provide individualized effective treatment approaches
efficient method realization paired algorithm calculation one dimensional discrete fourier transform dft simplifying signal flow graph transform described signal flow graph modified separating calculation real imaginary parts inputs outputs signal flow graph using properties transform examples calculation eight point dfts considered detail calculation point dft real data requires real multiplications additions two multiplications additions used eight point dft
paper analyzes effects external shocks emerging asian economies since asian crisis impact external shocks regional economies grown important asian business cycles well decision making process macroeconomic policies emerging asian economies become integrated global economy paper designs state space representation panel vector autoregressive model latent dynamic components order show impulse response function three external shocks including real income shock financial shock long term real interest rate shock paper finds external real gross domestic product shock dominant one emerging asia shock persistent carried long term effects emerging asia asian crisis second external equity shock also important factor influencing business cycles region asian crisis effect insignificant asian crisis last external monetary shock presumably mitigated effectively asia macroeconomic policy forced give monetary independency region
sports participation major ally promotion physical activity however sports injuries important adverse effects sports participation monitored sports populations purpose paper review basic concepts injury monitoring discuss implementation concepts practice aspects discussed sports injury definition classification sports injuries population risk prevalence incidence severity measures economic costs systems developed monitor sports injuries online technology reliable monitoring systems applied continuous long term manner possible identify burden injuries identify possible cases early stage implement early interventions generate data sports injury prevention implementation sports injuries monitoring systems practice strongly recommended
resilience engineering recent paradigm development analysis control systems interact environment subject perturbances part failures resilience engineering many facets well studied control engineering like fault tolerance robust control paper propose mathematical model considers following aspects relevant resilience engineering uncertainty autonomy system environment interaction model extends stochastic hybrid systems markov decision processes capture system autonomy game theory capture system environment interaction model consider state constrained reachability problem defined stochastic hybrid systems give characterization solutions problem terms value function ergodic stochastic game
background black hispanic low income children bear greater burden chronic health conditions compared wealthier white counterparts federal law schools provide services children health conditions impair learning school services called individualized education programs ieps reduce disparities school outcomes paper examines extent children health conditions iep plan important first step understanding service utilization method andersen behavioral model used examine iep plan presence using national survey children health school aged children least one health condition examined using multivariable logistic regression analysis understand predisposing age sex race ethnicity enabling family neighborhood need health related factors predictors iep plan race ethnicity interaction terms tested moderating effects race ethnicity relationship predisposing enabling need factors iep plan results hispanic children less likely black children less likely iep plan compared white children black hispanic multiracial children likely iep plan family neighborhood resources range greater health needs health care needs range conclusion behavioral model useful predicting presence iep plans among racially ethnically diverse children health conditions important step understanding disparities healthcare access schools
electroacupuncture zhongliao improve symptoms overactive bladder oab urinary frequency urgency incontinence however performance compared acupoints remains unclear study investigated effects deep needling rats oab detecting urodynamics eight groups intervention group group deep needling group shallow needling non acupoint group needling non acupoint next weizhong group sanyinjiao group tongtian group hegu group results revealed deep needling prolonged intercontraction interval ici rats oab respectively post treatment post modeling furthermore change ici post modeling group significantly greater intervention groups significantly shortened vesical micturition time vmt elevated maximum detrusor pressure mdp also observed group respectively post treatment post modeling however statistically significant differences changes vmt mdp post modeling observed groups conclusion deep needling may inhibit acetic acid induced oab effectively
background ectopic pituitary adenoma presenting clival sphenoid mass rare clinical occurrence may mislead clinician result unnecessary interventions potential medicolegal consequences present one largest multi institutional case series review literature emphasis radiological findings critical preoperative workup methods retrospective chart review results nine patients identified ectopic pituitary adenomas sphenoid clivus four females five males median age years old range years common presenting symptom headache five patients presented mass arising clivus four presented mass sphenoid six patients demonstrated biochemical evidence hypersecretion full endocrinology panel masses showed evidence enhancement gadolinium propensity adjacent bone involvement lesions also predilection growth toward cavernous sinus carotid artery sellar floor surgical intervention performed eight patients eight patients tumors demonstrated immunoreactivity prolactin conclusions pituitary adenomas rarely present isolated sphenoid clival mass lesions displayed similar magnetic resonance imaging findings erosive growth pattern toward sellar floor cavernous sinus adjacent carotid artery patients clival parasellar lesions comparable features preoperative workup includes prolactin level alert physician consider ectopic pituitary adenoma differential prevent unnecessary surgery potential complications
paper devoted problem regulating heart rate response along predetermined reference profile cycle ergometer exercises designed training cardio respiratory rehabilitation controller designed study non conventional non model based proportional integral derivative pid controller pid controller commands transmitted biofeedback auditory commands heard interpreted exercising subject increase reduce exercise intensity however case purposes effectively communicating exercising subject change required exercise intensity timing feedback signal relative position pedals becomes critical feedback signal delivered pedals suitable position efficiently exert force may ineffective may turn lead cognitive disengagement user feedback controller note examines novel form control system expressly designed project system called actuator based event driven control system proposed control system experimentally verified using healthy male subjects randomly divided two separate groups along cross validation scheme statistical analysis employed test generalisation pid tunes derived based average transfer functions two groups revealed significant differences mean values root mean square tracking error two groups bpm furthermore results second statistical hypothesis test showed proposed pid controller novel synchronised biofeedback mechanism better performance compared conventional pid controller fixed rate biofeedback mechanism group bpm group bpm
genesis psychopath long debated typically within framework long held nature versus nature argument psychopaths born psychopathic molded society like personality disorders development psychopathic brain dynamic psychopath remains consistent albeit small part population one wonder psychopathy continues reappear generation generation explore characteristics psychopathic behavior current theories adaptive qualities behavior psychopathy manifests women argue psychopathic behavior selecting psychopathy psychopathy mental disorder increases likelihood set behaviors behaviors unique psychopath favor continued presence psychopaths population also discuss biological characteristics male brain may make susceptible psychopathy female brain elsevier ltd rights reserved
order improve rolling wear resistance rwr linear rolling guides lrg well prolong life machine tools various shape samples different units spaces ranged designed observation animals desert manufactured laser cladding wear resistance tests reproducing closely real operational condition conducted using homemade linear reciprocating wear test machine wear resistance evaluated means weight loss measurement results indicate samples bionic units better rwr untreated one reticulate treated sample unit space present best rwr specifically among punctuate treated samples mass loss increases increase unit space among striate treated samples mass loss changes slightly increase unit space attaining minimum unit space among reticulate treated samples increase unit space mass loss initially decreases turns increase reaching minimum unit space additionally samples striate shape perform better wear resistance shape groups whole ratio value laser treated area contacted area perspective samples ratio value possess better wear resistance concluded
background soccer sport played worldwide growing participation rate american australasian regions generally played children adolescents often play adulthood inexpensive provides exercise outlet aggression appears safe activity ideal sport widespread youth participation possessing low injury rate preadolescent adolescent age groups risk injury increases age participants methods literature search medline database including articles outdoor soccer synthesized discussion potential risk factors injury preventive strategies discussed epidemiology various soccer injuries presented appropriate different age groups relation common sporting activities specific injury sites pathologies incurred areas detailed conclusion injuries common ankle knee joints injury muscle commonly occurring thigh pre adolescents participants lowest rate injury compared age groups incidence injury increasing age recognition risk factors practitioner advice implementation appropriate safety equipment help minimize number injuries occurring soccer field
existing measures emotion dysregulation typically assess dispositional tendencies therefore well suited study designs require repeated assessments brief intervals aim study develop validate state based multidimensional measure emotion dysregulation psychometric properties state difficulties emotion regulation scale ders examined large representative community sample young adult women drawn four sites exploratory factor analysis suggested four factor solution results supporting internal consistency construct validity predictive validity total scale four subscales nonacceptance nonacceptance current emotions modulate difficulties modulating emotional behavioral responses moment awareness limited awareness current emotions clarity limited clarity current emotions ders scores significantly associated trait based measures emotion dysregulation affect intensity reactivity experiential avoidance mindfulness well measures substance use problems moreover significant associations found ders state based laboratory measures emotional reactivity even controlling corresponding original ders scales results provide preliminary support reliability validity ders state based measure emotion regulation difficulties
letter use quantum information security enabler future driverless vehicle explored specifically role combined classical quantum information important characteristic driverless vehicle paradigm vehicle location investigated using information theoretic verification frameworks coupled emerging quantum based location verification procedures vehicle positions authenticated probability error simply attainable classical networks shown quantum applications seamlessly encapsulated within vehicular communication infrastructure required location verification also discussed two technology enablers required driverless quantum vehicle increase current quantum memory timescales likely wide scale deployment classical vehicular communication infrastructure underway argued enhanced safety features delivered quantum car mean eventual deployment inevitable
leukodystrophies genetic leukoencephalopathies rare group disorders leading progressive degeneration cerebral white matter associated spectrum clinical phenotypes dominated dementia psychiatric changes movement disorders upper motor neuron signs mutations least genes lead leukoencephalopathy often overlapping clinical radiological presentations reasons patients genetic leukoencephalopathies often endure long diagnostic odyssey receiving definitive diagnosis may receive diagnosis study used focused whole exome sequencing evaluate cohort undiagnosed adult patients referred specialist leukoencephalopathy service total patients evaluated using focused exome sequencing genes detected pathogenic likely pathogenic variants cases frequently mutated genes notch eifb aars csfr carried whole exome sequencing remaining negative cases including four family trios could identify potentially disease causing mutations confirming equivalence focused whole exome sequencing diagnosis genetic leukoencephalopathies provide overview clinical genetic features disorders adults
method birth control often called revolutionary implemented many western countries contraceptive pill allowed women engage sexual experiences without permanent fear pregnancy safe method especially important group unmarried newlywed women middle academic vocational education wanted combine career family life however especially influence women liberation movement attitudes towards pill changed longer seen emancipation female sexuality instrument going male domination sexuality society general according point view issues sexuality contraception far regarded private became political women directly linked personal intimate experiences questions power gender relations society often meant stopping taking pill article examines particular reasons shift contraceptive behaviour west germany england analyses changing attitudes feminist activists toward pill influence women decisions birth control
background early weak treatment response one trans diagnostic treatment agnostic predictors poor outcome following full treatment course sought improve outcome clients weak initial response guided self help cognitive behavior therapy gsh method one hundred nine women binge eating disorder bed bulimia nervosa dsm received weeks gsh based response grouped early strong responders continued gsh cgsh early weak responders randomized dialectical behavior therapy dbt individual additional group cognitive behavior therapy cbt results baseline objective binge eating day obd frequency similar dbt cbt cgsh treatment obd frequency reduction significantly slower dbt cbt relative cgsh relative cgsh obd frequency significantly greater end dbt cbt although effects small within treatment effects baseline large respectively obd improvements significantly diminished groups months follow significantly better sustained dbt relative cgsh month follow assessments dbt cbt cgsh differ obd conclusions early weak response gsh may overcome additional intensive treatment evidence insufficient support superiority either dbt cbt early weak responders relative early strong responders cgsh helpful future studies using adaptive designs needed assess use early response efficiently deliver care large heterogeneous client groups
background use noninvasive ventilation constantly evolving treatment option respiratory disease premature infant goals noninvasive ventilation techniques improve gas exchange premature infant lungs minimize need intubation invasive mechanical ventilation purpose goals article consider various uses nasal interfaces discuss skin care developmental positioning concerns faced bedside nurse discuss medical management aimed reduce morbidity mortality article explores nursing role advances medical strategies noninvasive ventilation team approach noninvasive ventilation use population search strategy search strategy included literature review medical databases ebscohost cinahl pubmed neoreviews findings innovative products nursing research developmental positioning skin care advanced medical management led better safer outcomes premature infants requiring noninvasive ventilation implications practice medical focus avoiding long term mechanical ventilation would possible without technology provide noninvasive ventilation premature infants watchful eye nurse terms careful positioning preventing skin breakdown facial scarring proper seal maximize ventilation accuracy implications research article encourages nursing based research quantify knowledge skin care positioning well research appropriate uses noninvasive ventilation devices
background holding chambers spacers enhance efficacy pressurized metered dose inhalers pmdi delivering inhaled medications reduce need hand breath coordination improve lower airways deposition nevertheless cost high patients low income countries objective compare asthma control achieved beclomethasone dipropionate administered hydrofluoroalkane driven pmdi bdp pmdi coupled home made spacer hms valved commercial spacer vcs auxiliary devices methods sixty three patients poorly controlled asthma bdp pmdi prescription randomized use inhaler coupled hms made plastic bottles group hms vcs group vcs days given training sessions asthma control assessed asthma control test act forced expiratory volume first second fev measured days treatment began results groups showed significant improvement act scores days compared baseline values increase points hms group points vcs group respectively statistically significant difference act scores groups observation time fev showed behavior conclusions similar level asthma control achieved beclomethasone dipropionate administered pmdi whether inhaler coupled hms vcs results significant asthma control planning strategies low income communities trial register number rbr xdc elsevier ltd rights reserved
bipolar disorder major depressive disorder mdd heritable neuropsychiatric disorders associated disrupted circadian rhythms hypothesis circadian clock dysfunction plays causal role disorders endured decades difficult test remains controversial meantime discovery clock genes cellular clocks revolutionized understanding circadian timing cellular circadian clocks located suprachiasmatic nucleus scn brain primary circadian pacemaker also throughout brain peripheral tissues mdd patients defects found scn dependent rhythms body temperature melatonin release however imperfect indirect indicators scn function moreover scn may particularly relevant mood regulation whereas lateral habenula ventral tegmentum hippocampus also contain cellular clocks established roles regard dysfunction non scn clocks could contribute directly pathophysiology mdd hypothesize circadian clock dysfunction non scn clocks trait marker mood disorders encoded pathological genetic variants network features scn render uniquely resistant perturbation previous studies scn outputs mood disorders patients may failed detect genetic defects affecting non scn clocks include mood regulating neurons brain also peripheral cells accessible human subjects therefore reporters rhythmic clock gene expression cells patients mouse models could provide direct assay molecular gears clock cellular clocks likely representative scn mood regulating neurons patients approach informed new insights tools modern chronobiology allow definitive test role cellular circadian clocks mood disorders
introduction amiodarone used management tachyarrhythmias associated hypothyroidism thyrotoxicosis total thyroidectomy effective procedure promptly reducing circulating thyroid hormone levels proposed patients severe amiodarone induced thyrotoxicosis ait refractory medical therapy therapy contraindicated therapeutic plasma exchange tpe may considered pretreatment restoring euthyroid state preoperatively thereby reducing patient symptoms potential perioperative risk associated thyrotoxicosis case report describe case year old man type ait presented severe unremitting thyrotoxicosis weeks medical therapy glucocorticosteroids thiamazole potassium perchlorate given severity presentation total thyroidectomy indicated tpe performed preoperatively successful rapidly restoring euthyroidism dramatically improved patient symptoms suggestive ischemic heart disease subsequently patient underwent total thyroidectomy general anesthesia without major complications conclusion tpe successful rapidly restoring clinical biochemical euthyroid state may used decrease perioperative risks associated thyroidectomy patients life threatening thyrotoxicosis cases refractory medical treatment european thyroid association published karger basel
present meg source reconstruction method simultaneously reconstructs source amplitudes identifies source interactions across whole brain proposed method full multivariate autoregressive mar model formulates directed interactions effective connectivity sources mar coefficients entries mar matrix constrained prior knowledge whole brain anatomical networks inferred diffusion mri moreover increase accuracy robustness method apply fmri prior spatial activity patterns sparse prior mar coefficients observation process meg data source dynamics series priors combined bayesian framework using state space representation parameters source amplitudes mar coefficients jointly estimated variational bayesian learning algorithm formulating source dynamics context meg source reconstruction unifying estimations source amplitudes interactions identify effective connectivity without requiring selection regions interest method quantitatively qualitatively evaluated simulated experimental data respectively compared non dynamic methods interactions estimated source reconstruction dynamic constraints proposed dynamic method improves performance measures simulations provides better physiological interpretation inter subject consistency real data applications authors published elsevier inc
recent years increasing interest permanent observation dynamic behaviour bridges long term monitoring purpose due ageing lot structures also dealing increasing complexity new bridges long term monitoring bridges produces huge quantity data need effectively processed purpose growing interest application soft computing methods particular work deals applicability bayesian neural networks identification damage cable stayed bridge selected structure real bridge proposed benchmark problem asian pacific network centers research smart structure technology ancrisst shared data coming long term monitoring bridge structural health monitoring community order assess current progress damage detection identification methods full scale example data set includes vibration data bridge damaged useful testing new approaches damage detection first part paper bayesian neural network model discussed second part bayesian neural network procedure damage detection tested proposed method able detect anomalies behaviour structure related presence damage order obtain confirmation obtained results last part paper compared obtained using traditional approach vibration based structural identification
review examine common usage term third wave scientific literature systematically review published meta analyses identified third wave therapies consider implications options use third wave metaphor describe nature relationships among cognitive behavioral therapies demonstrate third wave term grown use time commonly linked specific therapies majority therapies amassed compelling evidence base attesting clinical public health value also consider extent third wave designation effective guide future encourage scientific inquiry self reflection among concerned cognitive behavioral therapies scientific basis psychotherapy broadly
achieving high resolution low power sensor interface time domain processing using full digital circuits deals two voltage levels supply voltage ground level presented much broader sense digital circuits used time domain processing instead conventional analog signal processing study digital bit adaptive sensor interface adc experimentally evaluated high resolution low power operation along high scalability circuit architecture completely digital using ring delay line rdl driven input voltage power supply resolutions controlled setting conversion time resulting bit bit prototype low cost digital cmos achieving sensor digitizer sensor digitization product pressure sensor asic digital structure scaled technology test presented higher performance lsb finally digitization application circuit demonstrated realize time domain processing signal working mixer adc achieving minimum maximum detectable sensitivity vrms mvrms respectively khz sine wave lna input terminal digital cmos one chip radio controlled clock receiver
relatively small key size elliptic curve cryptography ecc considered public key cryptographic algorithm choice wireless sensor networks wsns work implemented ecc frequency domain using number theoretic transform without using hardware multiplier support constrained msp microcontroller widely used wsns bit ecc implementation uses edwards curves performs scalar point multiplication multiplication random fixed points respectively unlike many implementations literature implementation use hardware multiplier support makes desirable low power applications constrained wsn platforms knowledge study presents first ever software implementation ecc frequency domain constrained low power microcontroller without hardware multiplier support copyright john wiley sons ltd
psychological treatment choice obsessive compulsive disorder ocd exposure response prevention erp however training required practitioners proficient delivering erp readily available thereby rendering treatment inaccessible patients self directed erp serp programs designed increase accessibility erp proven effective perhaps patients find difficult comply exposure exercises without guidance clinician research cognitive bias modification cbm suggests cbm may help individuals approach feared situations case study patient ocd completed week treatment program combines serp cbm treatment led significant decrease ocd symptoms functional impairment results suggest novel treatment requires initial couple sessions clinician trained erp potential increase accessibility erp patients ocd wiley periodicals inc
relative age effect rae well established phenomenon education sports coaches assumed important social agents rae via biased selection decisions favour children maturation advantages present research used implicit association test investigate automatic associations body size player domain specific giftedness amongst youth baseball youth soccer coaches found medium strong automatic associations body size player giftedness baseball soccer specifically taller players associated positive performance related attributes whereas smaller players associated negative attributes results line theories grounded cognition showing abstract concept sport giftedness partly grounded perception physical height amongst youth sports coaches argue grounded cognition potential influence coaches selection decisions turn account rae coaches biased towards physically matured players even apparent performance advantage evident
objective evaluate clinical signs symptoms would help clinicians consider pseudohypoparathyroidism php type diagnosis child methods retrospective review medical records children diagnosed erythrocyte alpha activity gnas gene study followed php type clinical biochemical parameters along epidemiological data extracted analyzed weight gain infancy early childhood calculated change weight standard deviation score sds using french growth reference values upward gain weight sds periods considered indicative overweight obesity results ten cases php type identified mean age months range months children agedtpl exon cases conclusion based results php type considered toddlers presenting round face rapid weight gain subcutaneous ossifications subclinical hypothyroidism older children moderate mental retardation brachydactyly afebrile seizures short stature thyroid stimulating hormone resistance suggestive features
visual information plays critical role assessment music performance audiovisual integration well recognised person perception people readily match talking faces speaking voices effect exists identifying music performers strength untested study investigated importance visual audio priming identifying music performer line half participants saw target saxophonist sound heard line visuals saxophonists playing saxophonists contrast half participants heard target saxophonist visuals saw line sound participants identified target saxophonist visual audio line ups rate chance although identification accuracy decreased line number increased saw targets identified significantly greater number performers audio line heard targets identified visual line task complexity number distractors increased responses remained consistent visual priming robust reliable performer identification
background efficacy enteral nutrition maintaining remission patients inactive crohn disease unclear aim article systematically identify review critically appraise evidence efficacy maintaining medically induced remission materials methods several databases searched inception april relevant citations published randomized controlled trials nonrandomized cohort studies two reviewers independently selected studies inclusion assessed study quality risk bias primary outcome relapse rate patients inactive medically induced remission subsequently started maintained results twelve studies patients including children fulfilled inclusion criteria included studies significantly heterogeneous meta analysis performed eleven studies showed either better effective comparator maintaining remission patients inactive major related adverse events reported adult randomized controlled trial low risk bias compared regular diet found relapse rate group versus control group mean follow months conclusions effective regular diet effective medications maintaining remission patients inactive large properly designed randomized controlled studies sufficient duration required confirm conclusion versus individual medications
instream wood promotes habitat heterogeneity influence flow hydraulics channel geomorphology within columbia river basin usa wood vital creation maintenance habitat threatened salmonids however understanding relative roles climatic geomorphic ecological processes source wood streams limited making difficult identify baseline predictions instream wood create targets stream restoration investigate instream wood frequency volume differ seven sub basins interior columbia river basin processes shape differences within sub basins collected data wood volume frequency discharge stream power riparian watershed forest structure use modelling wood volume frequency using random forest models found mean annual precipitation riparian tree cover individual watershed important predictors wood volume frequency within sub basins used linear models finding basins unique predictors wood discharge watershed area precipitation often combined forest cover riparian conifer large tree cover models instream large wood volume frequency many sub basins models showed least one hydrologic variable indicative transport competence one ecological variable indicative reach upstream watershed capability grow measurable instream wood conclude basin specific models yield important insights hydrologic ecological processes influence wood loads creating tractable hypotheses building predictive models instream wood copyright john wiley sons ltd
candida krusei krusei pneumonia rare infection frequently associated poor outcome present study reports unusual case krusei pneumonia initially suspected middle east respiratory syndrome mers case year old saudi arabian male patient admitted hospital complaints cough dyspnea persisted days patient presented fever oral temperature degrees slight tachypnea respirations min chest computerized tomography demonstrated unclear lung fields diffuse pathological changes two lungs multiple lymphadenectasis retrocaval para aortic arch area patient received oxygen min well sulbactam sodium cefoperazone sodium injection every oral oseltamivir capsules time twice day medaron injection time fluid infusion however succumbed disease day admission infection diagnosed sputum smear culture subsequent patient mortality sputum smear showed large fungal infection sputum culture revealed presence krusei infection serum procalcitonin concentrations days admission respectively conclusion diagnosis candida pneumonia strongly considered presence growth candida sputum culture based suggestive computed tomography image tumescent diaphragmatic lymph nodes may also important symptom candida pneumonia treatment initiated immediately improve tissue oxygenation restore cardiovascular function improve organ functions
paper introduces novel multi control area framework explicit modeling managing accounting simultaneous bilateral transactions specified contract paths framework provides modular multi layered electrical network representation zooming zooming capabilities zoomed representation concerns interconnections inter area transactions zoomed representation concerns single area internal transactions framework allows explicit modeling bilateral transactions contract paths transformation meshed electrical network spanning tree loop flows introduced represent deviation contract paths bilateral transactions physical line flows effects intra area inter area bilateral transactions loop flows graphically traced framework moreover tracing methods allocate bilateral transactions line flows loop flows essential accounting flow control tracing methods differ distribution factor based method distribution factor matrix handles nodal injections account contract paths bilateral transactions resulting loop flows multi layered network transformations tracing methods illustrated ieee bus system
recent years many flight control systems industries employing pid controllers improve dynamic behavior characteristics paper pid controller developed improve stability performance general aviation aircraft system designing optimum pid controller parameters pitch control aircraft important expanding flight safety envelope mathematical model developed describe longitudinal pitch control aircraft pid controller designed based dynamic modeling aircraft system different tuning methods namely zeigler nichols method modified zeigler nichols method tyreus luyben tuning astrom hagglund tuning methods employed time domain specifications different tuning methods compared obtain optimum parameters value results prove pid controller tuned zeigler nichols aircraft pitch control dynamics better stability performance conditions future research work obtaining optimum pid controller parameters using artificial intelligence techniques carried
sex determining region box sox oncogene known amplified overexpressed various human malignancies including lung squamous cell carcinoma scc however role played sox lung scc development remains elucidated measured levels sox cyclin mrna protein expression lung scc tissues lung scc cell line found levels dramatically upregulated specimens lung scc tissue compared expression levels samples adjacent nonneoplastic tissue lung scc cell line also showed higher levels sox cyclin expression normal human bronchial epithelium cell line using rna interference knock sox expression nci lung scc cells proliferation reduced furthermore overexpression sox promoted proliferation normal human bronchial epithelium cells determine whether cyclin downstream target gene sox measured levels cyclin expression occurred sox knocked overexpressed sox knockdown significantly decreased levels cyclin mrna protein expression sox overexpression upregulated levels cyclin used bioinformatics data identify potential cyclin promoter binding sites sox results luciferase reporter assays electrophoretic mobility shift assays chromatin immunoprecipitation assays confirmed cyclin direct target transcription factor sox human lung scc cells
improved magnetic properties alloys widely used new electric motor generations use punching process obtain components specially affects mechanical behavior fatigue strength work aims studying influence punching operations fatigue behavior alloy high cycle fatigue tests performed different smooth specimen configurations either punched polished edges results show significant decrease fatigue strength punched specimens compared polished ones understand origin fatigue failure punched specimens sem observations fracture surfaces carried reveal crack initiation always occurs punch defect additional experimental techniques combined characterize edges altered punching impact punching operations residual stresses hardening investigated residual stresses quantified punched edges using ray diffraction techniques important tensile residual stresses exist loading direction result punching operations also according xrd analyses micro hardness measurements hardened zone depth dissociate respective influences strain hardening residual stresses geometrical defects heat treatment applied punched polished specimens order quantify contribution parameter high cycle fatigue resistance results show geometry defects one influent parameters consequently finite element model developed simulate influence edge defects fatigue strength punched components non local high cycle fatigue criterion finally used post processing fea consider effect defects associated stress strain gradients hcf strength assessment copyright authors published elsevier
angus macdonald bridge crosses halifax harbour nova scotia existing deck replaced reached end service life design new superstructure replacement sequence completed contractor replacing entire suspended structure hangers sequentially night weekend closures bridge kept open daytime traffic effects erection sequence bridge behaviour supported sophisticated automated erection analysis models account geometry existing bridge positioning erection equipment deck necessary hanger strand jack adjustments required construction prevent overloading structure design involved significant wind tunnel testing analysis ensure aerodynamic stability erection final condition
electric machines key component electric hybrid electric vehicle hev powertrains thus computationally efficient models electric machines essential powertrain level design simulation optimization paper finite element based method quickly generating torque speed curves efficiency maps electric machines presented first magnetostatic finite element analysis fea conducted base machine design analysis produces torque normalized losses flux linkage maximum magnetic field intensity permanent magnets wide range currentmagnitudes phase angles values scaled based upon changing size machine effective number turns machine windings quickly generate variety new machine designs corresponding efficiency maps using postprocessing techniques results suggest avoiding resolving fea scaled designs proposed techniques used quickly generate efficiency maps thus useful hev powertrain level simulation optimization
neuroimaging forms important part dementia diagnosis provision information neuroimaging people dementia carers may aid understanding pathological physiological psychosocial changes disease increase understanding symptoms qualitative study aimed investigate participants knowledge dementia diagnosis pathway understanding neuroimaging use diagnosis determine content requirements website providing neuroimaging information structured interviews focus group conducted carers people dementia findings demonstrate unmet need information neuroimaging examination carers keen know neuroimaging practical technical level help avoid diagnosis denial people dementia requested greater information caveat avoid overwhelming detail less likely favour internet resource
hiv related stigma among persons living hiv aids plhiv prevalent throughout sub saharan africa limited evidence however interventions effective reducing used data prospective impact evaluation month food assistance intervention among antiretroviral therapy art plhiv uganda examine program impact stigma stigma measured using comprehensive hasi scale demonstrated good internal consistency cronbach alpha correlated several related constructs including physical mental health related quality life disclosure physical health symptoms sample using quasi experimental difference difference matching methods better infer causality tested whether intervention improved overall stigma scale subscales food assistance intervention significant effect reported internalized external stigma approximately hasi stigma scale useful tool measuring tracking stigma food assistance interventions embedded hiv care program reduce internalized stigma
many ways achieve knowledge experience presented paper one describes knowledge achievement process thru knowledge models case using concept maps subject experiment design knowledge model technical subject turning project participants students terminal year engineering faculty sibiu lucian blaga university especially technical field one knowledge information interpreted result hard reach important quantity information absence right connections made remain raw dates difficult understand hard integrate real technical context order solve given problem
manufacturing engineering refers design production process product including considerations pertaining process production along rapid development global economic integration manufacturing enterprises country increasing pressure today ever changing competitive environment taking initiative innovation important way improve competitiveness manufacturing enterprises staffs innovation behavior important factor organization innovation data samples subjects analyzed software spss amos samples different regions industry country reveals generation mechanism individual innovation behavior jib develop new materials new energy manufacturing enterprises favorable organizational innovation climate effective improve innovation management encouraging affective commitment staff
pure zno doped zno nano powder synthesized precipitation method detailed xrd analysis shows prepared nanocrystalline samples single phase wurtzite structure relative increment bragg peak observed due one dimensional growth ions doped zno saed pattern tem images confirm single phase wurtzite structure nano ampoule shape doped zno vis measurements absorption edge blue shifted doping zno lattice tuned band gap zno doping offers potential application solar cells elsevier rights reserved
background aim determine association melanopsin gene polymorphism pupillary light reflex diverse photic conditions including different intensities wavelengths methods total visually corrected subjects volunteered investigation melanopsin gene single nucleotide polymorphism snp genotype groups subjects including subjects participated experiment three monochromatic lights peak wavelengths blue green red prepared light projected subjects five intensities log photons one minute pupil size left eye measured light condition minute adaptation results pupils genotypes significantly smaller genotype blue light condition log photons contrast significant differences green red light conditions conversely relative pupil constrictions genotypes greater genotype blue green conditions high intensities log photons contrast significant differences genotype groups pupil size relative pupilloconstriction red light conditions conclusions findings suggest melanopsin gene polymorphism functionally interacts pupillary light reflex depending light intensity particularly wavelength light condition fulfilling high intensity short wavelength pupillary light response subjects allele sensitive light subjects genotype
whereas number studies examined relationships among brain activity social cognitive skills autistic traits fewer studies evaluated whether structural connections among brain regions relate traits skills uncinate fasciculus inferior longitudinal fasciculus ilf white matter tracts may underpin behavioral expression skills connect regions within provide sensory information brain areas implicated social cognition structural differences tracts associated autistic traits examined relationships among self reported autistic traits mentalizing water diffusivity ilf nonclinical sample young adults mean age years years women measured autistic traits using autism spectrum quotient measured mentalizing using dynamic interactive shapes clips task used tract based spatial statistics randomize examine relationships among fractional anisotropy values bilateral ilf age cognitive abilities autistic traits mentalizing autistic traits positively related values left ilf relationships values variables significant results suggest left ilf may involved expression autistic traits individuals without clinical diagnoses
research archival samples population based studies shown light eyed individuals especially blue eyed individuals consumed alcohol dark eyed individuals field study carried french barroom hypothesized average blood alcohol concentration participants blue eyes would higher people eye color measured blood alcohol concentration breathanalyzer among customers various occupational backgrounds calculated association eye color bac results showed among males females irrespective age participants blue eyes higher bac others mean bac also higher among men women ecological result suggests iris pigmentation represents biological marker underlying factors involved higher alcohol consumption various hypothetical mechanisms considered
across three experiments examined efficacy three cues human body body orientation head turning eye gaze direction shift observer attention space using modified posner cueing paradigm replicate previous findings gender differences gaze cueing effect whereby female male participants responded significantly faster validly cued invalidly cued targets contrast previous studies report robust cueing effect male female participants head turning direction used central cue whereas oriented bodies proved ineffectual cues attention males females results discussed reference time course central cueing effects gender differences spatial attention current models cues human body combined judge another person direction attention
background incidence lower extremity injuries female soccer players high risk factors injuries unknown purpose investigate risk factors lower extremity injuries elite female soccer players study design cohort study level evidence methods players norwegian elite female soccer league teams participated baseline screening tests competitive soccer season screening included tests assessing maximal lower extremity strength dynamic balance knee valgus angles drop jump landing knee joint laxity generalized joint laxity foot pronation also included questionnaire collect information demographic data elite level experience injury history time loss injuries exposure training matches recorded prospectively subsequent soccer season using weekly text messaging players reporting injury contacted collect data regarding injury circumstances univariate multivariate regression analyses used calculate odds ratios ors confidence intervals cis standard deviation change results total players underwent complete screening tests registration injuries exposure throughout season total injuries players recorded ligament muscle injuries frequent multivariate analyses showed greater body mass index bmi factor significantly associated new lower extremity injuries greater bmi associated new thigh injuries lower knee valgus angle drop jump landing associated new ankle injuries previous knee injury associated new lower leg foot injuries whereas none factors investigated influenced risk new knee injuries conclusion greater bmi associated lower extremity injuries elite female soccer players clinical relevance increased knowledge risk factors lower extremity injuries enables targeted prevention strategies aim reducing injury rates female soccer players
erythroblastic islands multicellular clusters central macrophage supports development maturation red blood cell erythroid progenitors clusters play crucial roles pathogenesis observed animal models hematological disorders precise structure function erythroblastic islands poorly understood combined scanning electron microscopy immuno gold labeling surface proteins develop better understanding ultrastructure multicellular clusters erythroid specific surface antigen ter transferrin receptor exhibited distinct patterns protein sorting erythroid cell maturation detected immuno gold labeling electron microscopy analysis observed two distinct classes erythroblastic islands islands varied size morphology number type erythroid cells interacting central macrophage assessment femoral marrow isolated cavid rodent species guinea pig cavis porcellus marsupial carnivore species fat tailed dunnarts sminthopsis crassicaudata showed morphology central macrophage varied two different types erythroblastic islands consistently identifiable findings suggest two classes erythroblastic islands conserved mammalian evolution may play distinct roles red blood cell production
research snake robot developed using ionic polymer metal composite ipmc one best artificial muscles electro active polymer eap group novel tendon driven parallel structure built single link snake robot kinematic analysis discussed actuator following analysis ipmc artificial muscle exceptional characteristics snake robot perform dof motion single joint perform flexible motion light weight special characteristics enhance snake robot operate hazardous area disaster recovery mission elsevier ltd rights reserved
study design retrospective database review objective aim study determine complication mortality rates patients years age older treated anterior cervical fusion surgery compare rates elderly patients summary background data cervical spondylosis frequently observed elderly common cause myelopathy older adults increasing life expectancies greater proportion patients treated spine surgery later age limited information available regarding outcomes following anterior cervical fusion surgery patients years age older methods medicare data pearldiver database queried patients underwent primary one two level anterior cervical spine fusion surgeries cervical spondylosis excluding patients prior spine metastasis bone cancer spine trauma spine infection cohort divided two study groups patients years old selected cohort matched control patients selected year old day complication rates day year mortality rates compared cohorts results proportion patients experiencing least one major medical complication relatively increased patients aged years odds ratio patients years age older likely experience dysphagia reintubation aspiration pneumonitis day year mortality significantly higher year cohort conclusion patients years age older likely experience major medical complication mortality following anterior cervical fusion cervical spondylosis patients years old dysphagia aspiration pneumonitis reintubation rates also significantly higher patients years age older although complication rates may higher patient population carefully selected patients could potentially derive much benefit surgery screened solely basis age
symptoms post traumatic stress disorder common fibromyalgia patients study compared post traumatic stress disorder symptoms fibromyalgia patients healthy controls determined whether patient control differences post traumatic stress disorder symptoms mediated differences mental health patients healthy controls completed questionnaires assessing symptoms post traumatic stress disorder mental health fibromyalgia patients greater symptoms post traumatic stress disorder mental health controls patient control differences mental health symptoms fully partially mediated differences post traumatic stress disorder symptoms healthcare providers understand role trauma management trauma symptoms may one strategy improving mental health
objective provide guidance organisation delivery clinical services clinical management patients deliberately self harm based scientific evidence supplemented expert clinical consensus expressed recommendations method articles information sourced search engines including pubmed embase medline psycinfo several systematic reviews supplemented literature known deliberate self harm working group published systematic reviews guidelines deliberate self harm information reviewed members deliberate self harm working group findings formulated consensus based recommendations clinical guidance guidelines subjected successive consultation external review involving expert clinical advisors public key stakeholders professional bodies specialist groups interest expertise deliberate self harm results royal australian new zealand college psychiatrists clinical practice guidelines deliberate self harm provide date guidance advice regarding management deliberate self harm patients informed evidence clinical experience clinical practice guidelines deliberate self harm intended clinical use service development psychiatrists psychologists physicians others interest mental health care conclusion clinical practice guidelines deliberate self harm address self harm within specific population sub groups provide date recommendations guidance within evidence based framework supplemented expert clinical consensus
introduction standardized patients beneficial component modern healthcare education training studies explored cognitive factors potentially impacting clinical skills assessment standardized patient encounters study examined impact periodic traditional postencounter evaluation approach appearance critical verbal nonverbal behaviors throughout standardized patient encounter scoring accuracy video based scenario methods forty nine standardized patients scored either periodically point time postencounter healthcare provider verbal nonverbal clinical performance videotaped standardized patient encounter healthcare provider portrayed study actually standardized patient delivering carefully scripted verbal nonverbal behaviors portrayal actual physician encounter subdivided distinct segments purpose supporting periodic evaluation expectation verbal nonverbal cues occurring middle segment would challenging accurately report participants postscenario evaluation group result working memory decay results periodic evaluators correctly identified significantly greater number critical verbal cues midscenario postencounter evaluators correctly identified significantly greater number critical nonverbal cues postscenario counterparts across scenario segments postscenario evaluations exhibited performance decrement terms midscenario correct identifications periodic evaluators also periodic evaluators exhibited fewer verbal cue false positives first segment scenario postscenario evaluators effect extend segments regardless cue type verbal nonverbal discussion pausing lengthier standardized patient encounters periodically allow frequent scoring may result better reporting accuracy certain clinical behavioral cues could enable educators provide specific formative feedback individual learners session conclusion effective encounter design ultimately depend specific goals training objectives exercise
background purpose aim facilitating early detection alzheimer disease alzheimer disease neuroimaging initiative proposed two stages based memory performance early mild cognitive impairment emci late mild cognitive impairment lmci current study designed investigate structural differences terms surface atrophy microstructural changes hippocampus emci lmci methods hippocampal shape modeling based progressive template surface deformation performed weighted mri images obtained cognitive normal subjects emci patients lmci patients template surface used region interest diffusion tensor imaging dti voxel based morphometry vbm analysis cluster wise group comparison performed based dti indices within hippocampus linear regression performed identify correlations dti metrics clinical scores results hippocampal surface analysis showed significant atrophies bilateral cal regions right ventral subiculum emci contrast widespread atrophy lmci dti vbm analysis showed increased diffusivity regions emci additionally subiculum region lmci hippocampal diffusivity significantly correlated scores mini mental state examination modified alzheimer disease assessment scale cognitive subscale however hippocampal diffusivity vary significantly fractional anisotropy conclusions emci showed hippocampal surface changes mainly region ventral subiculum diffusivity increased mainly regions emci decreased throughout hippocampus lmci although axial diffusivity showed prominent changes right hippocampus emci future studies need confirm presence laterality difference addition diffusivity strongly correlated cognitive performance indicating possibility using diffusivity biomarker disease progression
three pre mixed clay based plasters successfully employed green building practices several european countries spain france germany united kingdom mainly used interior wall coating finishing tested paper compositional textural characteristics well plastic behaviour investigated multi analytical approach previous paper natural earth terra rossa red soil sampled north western sicily theoretically appropriate production earthen plaster also subjected analytical routine compared three commercially available products humidity control capacity determination equilibrium moisture content sound absorption coefficient thermal conductivity green building materials tested according italian european regulations achieved results allowed individuation compositional textural features primarily influence performances studied clay based plasters obtained data expected also useful selection suitable raw materials directing local manufacture innovative products elsevier rights reserved
background past research underscores key role coping strategies development maintenance exacerbation posttraumatic stress disorder ptsd symptoms goal current study extend existing literature examining whether race ethnicity moderates relations among coping strategies social support problem solving avoidance ptsd symptom clusters intrusion avoidance numbing arousal methods participants community women african americans latinas whites reported bidirectional aggression current male partner multigroup path analysis utilized test moderating role race ethnicity model linking coping strategies ptsd symptom clusters results strength direction relations among coping strategies ptsd symptom clusters varied function race ethnicity greater social support coping related arousal symptoms latinas whites greater problem solving coping related fewer arousal symptoms latinas greater avoidance coping related symptoms across many ptsd clusters african americans latinas whites however relations strongest african americans conclusion results provide support moderating role race ethnicity relations among coping strategies ptsd symptom clusters highlight potential targets culturally informed ptsd treatments
paper presents formalism parametric integral equation system pies two dimensional elastoplastic problems algorithm numerical solution efficiency proposed approach lies global modeling plastic zone without classic discretization elements using surface patches popular computer graphics lagrange polynomials various number arrangement interpolation nodes used approximate plastic strains three test examples solved obtained results compared analytical numerical solutions elsevier ltd rights reserved
youth exposed community violence parenting found play significant role protecting adolescents associated mental health symptoms yet little known potential parenting prevent exposure first place thereby reduce likelihood adolescents mental health symptoms study examined two parental practices often examined moderators yet predictors youth exposure community violence associations adolescent mental health namely parental control parental harshness analyses self reported data adolescents age girls non hispanic white revealed harsh parenting indirectly associated youth mental health symptoms higher levels exposure community violence whereas links controlling parenting mental health symptoms either non significant mediated lower levels adolescent violence exposure findings highlight potential positive role parental control may play preventing adolescents exposure potentially dangerous situations conversely results suggest harsh parenting appears pose risk adolescents driving youth away home environment potentially places violence may prevalent
stereovision based methodology estimate position speed heading moving marine vehicle pursuing unmanned surface vehicle usv considered support enabling usv follow target vehicle motion methodology involves stereovision ranging object detection tracking minimization tracking error due image quantization limitations pixel miscorrespondences stereo pixel matching process method consists combining simple stereovision matching algorithm together predictive corrective approach based extended kalman filter ekf use suitable choices probabilistic models representing motion target vehicle stereovision measurements simple matching algorithms perform faster expense potential errors depth measurement approach considered aims minimize tracking errors related errors stereovision measurements thereby improving accuracy state estimation vehicle results simulations real time implementation reveal effectiveness system compute accurate estimates state target vehicle non compliant trajectories subjected variety motion conditions
purpose despite increasing interest offshoring knowledge intensive services still undetermined whether sourcing services truly creates anticipated value clients moreover even less known whether value created service providers process beyond general service trade lack knowledge due challenges capturing value creation unique production process services impact offshoring value creation production process purpose paper study offshored service production processes knowledge intensive services order identify direct indirect value creation clients well service providers process design methodology approach paper applies multiple case study method studies one conglomerate three offshored service production processes chosen method allows investigation service production process indirect direct value creation within process findings study finds direct value creation client service provider towards end production processes expected however importantly finds additional indirect value creation various production stages indirect value reflected enhanced understanding problems operations client increased knowledge clients problem solving approaches service provider research limitations implications study contributes offshoring literature providing comprehensive understanding value creation service offshoring clients well service providers also contributes service management literature study direct indirect value creation services particularly within production process services practical implications study allows practitioners gain insights value creation logic offshored services value created beyond logic specifically allows client firms gain details various values benefits service offshoring service provider firms gain focused perspective value creation service production lead competitive advantages originality value paper novel original approach study offshoring value creation logic perspective including client also service provider perspective also applies service production process perspective novel offshoring literature
openness diversity useful adjustment diversified modern society diversity perceived threat one identity cultural values thus tendency feel secure easily threatened attachment security may associated openness diversity path model hypothesized associations attachment insecurity attachment anxiety avoidance universal diverse orientation udo open attitude toward diversity directly indirectly low self esteem interpersonal trust structural equation modeling analysis using two samples respectively undergraduates revealed attachment anxiety associated udo cognitive component relativistic appreciation positively emotional component comfort differences negatively suggesting ambivalent attitudes diversity indirect effects significant attachment insecurity udo trust although self esteem associated udo association trust suggested mistrust others good intention might insecurely attached feel uncomfortable culturally different people elsevier ltd rights reserved
introduction growing knowledge wide ranging effects histamine throughout body therefore important better understand effects amine patients asthma aimed explore association histamine pharmacodynamic response genetic variation histamine pathway children asthma methods histamine lontophoresis laser doppler monitoring hild performed children asthma estimates area effect curve auec maximal response baseline emax time emax tmax calculated using non compartmental analysis non linear mixed effects model linked effect model dna isolation genotyping performed among participants detect known single nucleotide polymorphisms snps among genes hdc hnmt abp hrh hrh within histamine pathway general linear model used identify associations histamine related genetic variants measured histamine response parameters results genotyping hild response profiles completed children abp abp hnmt twere associated emax abp genotype mean emax genotype mean emax abp genotype mean emax genotype mean emax hnmt genotype mean emax genotype mean emax stratified analysis among african american children abp hnmt snps also associated response hrh genotype associated lower emax conclusions show first time histamine pathway genetic variation associated measureable changes histamine response children asthma variability histamine response impact histamine pathway genotype important explore patients asthma improve disease phenotyping leading personalized treatments
peer learning commonly expressed peer assisted learning pal involves school students actively assist others learn turn benefit effective learning environment research designed support students becoming autonomous learning help enhance confidence level tackling computer programming problems well encourage towards team work collective effort main purpose research test effectiveness pal programming language course second semester undergraduate level purpose experiment group peer students control group statistically compared terms midterm final exam scores results showed peer students successful programming language
paper fractional derivatives sense modified riemann liouville derivative exp function method expansion method generalized kudryashov method used construct exact solutions dimensional space time fractional modified kdv zakharov kuznetsov equation fractional equation turned another nonlinear ordinary differential equation fractional complex transformation three methods applied solve result new exact solutions obtained three methods demonstrate power reliability efficiency elsevier ltd rights reserved
traditional surveying methods soil properties landscapes dramatically cost time consuming thus remote sensing proper choice monitoring environmental problem research aims study effect environmental factors soil salinity map spatial distribution salinity southern east part tunisia means remote sensing geostatistical techniques purpose used advanced spaceborne thermal emission reflection radiometer data depict geomorphological parameters elevation slope plan curvature plc profile curvature prc aspect pearson correlation parameters soil electrical conductivity ecsoil showed mainly slope elevation affect concentration salt soil moreover spectral analysis illustrated high potential short wave infrared swir bands identify saline soils map soil salinity southern tunisia ordinary kriging minimum distance classification simple regression used findings showed ordinary kriging technique provides reliable performances identify classify saline soils study area root mean square error mean error
study examines mixed martial arts mma events marketed order understand role violence promoting events researchers examined pieces promotional artwork promotional news releases mma organisations across north america asia europe found pieces promotional artwork used violent text imagery violent text found news releases violence typically limited smaller european organisations results illustrate evolution sport suggesting violence may longer necessary promote events
ambulatory monitoring health care using wireless body area networks active area applied research study new method presented compute connectance reliability wireless body area networks based improved approach topological analysis network digraph using mason rule procedure outlined simple fast may used compute quantitative measures wireless body area network reliability life science journal issn
power supply rejection psr based closed loop low dropout regulator ldo analyzed achieve high psr ldo help designer meet psr requirement considering performances ldo using small signal model mos transistor kirchhoff current voltage law tool mathematica psr gain poles zeros power stage six kinds basic amplifiers ldo analyzed theoretically proved simulation cadence spectre tabling psr eight error amplifier composite structures two stages best combination nmos differential input amplifier pmos input common source amplifier proposed account psr property ldo containing best structure designed tsmc standard cmos process measurement result psr khz novel guideline improve psr ldo proposed provides afresh design idea measurement results agreement analysis also
present case woman bipolar disorder severe premenstrual mood instability confusion psychosis resembling clinical features postpartum psychosis estrogen levels expected low hypomania estrogen levels expected elevated depressive symptoms across menstrual cycle extensively documented literature little information regarding manic hypomanic symptoms addition describe successful treatment menstrual cycle related symptoms approaches management menstrual psychosis systematically studied clinical guidelines exist clinical experiences one reported clinical formulation patient consistent known neuroendocrine phenomena treatment approach successful crucial developing promising approaches tested controlled trials
aim work obtain optimum controller parameters advanced mechanical shim mshim control system mshim control system designed allow nuclear steam supply system nsss perform power change operations automatically mshim control system lead time constant lead lag ratio average coolant temperature avg controller rate lag constant low gain nonlinear gain unit power mismatch controller considered decision variables sensitivity analysis minimizing overshoot nuclear power maximum absolute deviation average coolant temperature target value multi objective problem four decision variables translated two subproblems lead time constant lead lag ratio tavg controller firstly optimized non dominated sorting genetic algorithm nsga power mismatch controller defeated rate lag constant low gain power mismatch controller optimized nsga optimized parameters tavg controller dynamic simulations performed based fast running nsss control analysis platform ncap iteration optimization process calculate objective functions percent step load increase transient full power selected simulation case optimization calculation results demonstrate much better reactor control capabilities provided mshim control system employing optimized control parameters elsevier ltd rights reserved
integration health education welfare services primary care systems key strategy solve multiple determinants chronic diseases human immunodeficiency virus infection acquired immune deficiency syndrome hiv aids however scarcity conceptual models build integration strategies provide model based cross sectional data community health agents nurses physicians two municipalities brazil unified health system uhs outcome service integration comprised hiv education community activities health walks workshops documentation services obtainment working papers birth certificates predictors included individual factors provider confidence knowledge skills perseverance efficacy job characteristics interprofessional collaboration work autonomy decision making autonomy skill variety organizational factors work conditions work resources structural equation modeling used identify factors associated service integration knowledge skills skill variety confidence perseverance predicted greater integration hiv education alongside community activities documentation services job characteristics organizational factors predict integration study offers explanatory model adapted examine variables may influence integration different services global primary healthcare systems findings suggest practitioner trainings improve integration focus cognitive constructs confidence perseverance knowledge skills
purpose review discuss place hypnotherapy modern medical world dominated called evidence based clinical practice hypnosis easily learned technique valuable adjuvant many medical dental psychological interventions
metal hydrides received much attention due flourishing concept hydrogen economy addition recent studies metal hydride materials shown technological implementation compounds lies storage hydrogen range multi functional applications including smart optical windows energy storage materials fuel cells stationary mobile devices thermal energy storage materials concentrating solar thermal plants review concentrates molecular structures thermodynamic properties physical properties complexes nih feh coh ruh synthesized derivatives compounds also reviewed give full overview advancement systems allow fresh prospective future studies fully understand physical chemical nature complex transition metal hydrides elsevier rights reserved
like many development towns established aftermath israel founding kiryat shemona situated demographic geographic margins state sits border lebanon galilee region historically major center israel palestinian population particularly moments cross border violence kiryat shemona becomes central margin place crucial imagining israeli nation reason inhabitants imagined others often steadfast strong qualities said center lsraeliness time like development towns kiryat shemona residents mainly mizrahim pushed populate marginal regions constitute majority israeli jewish population also many respects constitute class vis vis historically ashkenazi elite mizrahim development towns thus marginal center power vulnerable insecurity poverty associated towns inhabiting precarious borderlands crucial imagining bounded jewish israeli nation must defend article demonstrates mizrahim strived move symbolically margins exclusion center inclusion calling upon nation cosmopolitan connections everyday life mizrahim marked ethicized boundaries differentiated others thus reinforcing ethnoreligious logic israeli nationalism historically pushed margins state
article contributes development professional anthropological discourses audiovideo recording technologies ethnographic research synthesizing scholarship ethnographic partiality ethnography sound multimedia technologies article reflexively applies concepts transduction affordance analyze recorders may theorized part fieldwork encounters based fieldwork zulu gospel choir comprised people living hiv south africa discuss research participants guided use recorders amid inequality hiv stigma analyze ethical communicative affordances recording technologies examining design audio video technologies intersects cultural communicative conventions use evaluation use technologies analysis suggests ethical communicative affordances transducers yield extension ethnographer social self disconnect self ways productively navigated fieldwork
paper reviews divorce related parenting programmes assessing extent fathers included whether father inclusion influences outcomes paper also discusses limitations research evidence implications future intervention evaluation design thirteen programmes met criteria review period four evaluated using randomized control trials independent measures mothers fathers analysis four programmes shows modest evidence reduced couple conflict improved coparenting evidence improved child outcomes key issues raised need improving quantity quality demographic data fathers importance incorporating analysis gender parent evaluation design value developing routinely using father related indicators measure programme impact men parenting fathering parental relationships
megaprojects historically associated poor delivery terms schedule cost performance empirical research required determine characteristics megaprojects affect schedule cost performance capital intensive power plants understood megaprojects time delays cost escalation construction phase undermine overall economic viability paper presents systematic empirically based methodology employs fisher exact test identify characteristics power plant megaprojects ppms correlate schedule cost performance present results applying methodology dataset ppms using nuclear coal renewable resources case studies results highlight importance modular technologies project governance external stakeholder involvement key findings support contradict literature paper provides two major original contributions first present apply systematic empirical statistical approach understanding ppms planning construction second show approach used inform public policy project management regard ppms elsevier ltd rights reserved
technique fractional order model reference adaptive control fomrac applied automatic voltage regulator avr presented paper work focused tuning adaptive gains derivation order adaptive laws fomrac determined minimization criterion function defined simplified model avr means genetic algorithm optimization technique based criterion function proposed authors simulated comparative study performed comparing proposed methodology integer order pid control reported zamani shown fomrac parameters optimized provides better results terms robustness parameters variations system control improvements convergence speed control error
semantics programming languages studied long time still lacking unified framework easily formally specified formal definition used experimenting design process language analysis check language properties program verification analysis automated testing correct implementation paper surveys part results obtained joint effort made finding framework research groups formal system laboratory fsl university illinois urbana champaign usa formal methods software engineering fmse alexandru joan cuza university iasi romania dreampal inria lille nord europe france
atopic dermatitis chronic relapsing inflammatory skin disease failure treat successfully often directly linked poor treatment adherence result lack information disease basic principles treatment several studies found making patients active participants care information education successful treatment strategy aim study evaluate parental knowledge stress importance therapeutic educational program long term management control disease carried short questionnaire based study among parents children regarding knowledge etiology treatment results showed participants reported corticophobia concerned systemic absorption affecting child growth development even short application children food hypersensitivity parents thought small amount food allergen could beneficial achieving tolerability role interdisciplinary educational program explain epidemiology pathogenesis well concomitant atopy related diseases teach parents importance appropriate skin care
heap based priority queues common dynamical data structures used several fields ranging operating systems scientific applications however rise new multicore cpus introduced new challenges process design data structures addition traditional requirements like correctness progress scalability paramount importance common opinion two demands partially conflict computational environments necessary relax requirements correctness linearizability achieve high performances paper introduce loosely coordinated approach management heap based priority queues multicore cpus aim realize tradeoff efficiency sequential correctness approach based sharing information among small number cores improve performance without completely losing features data structure results obtained scientific problem show significant benefits terms parallel efficiency well term numerical accuracy
medium term scenario hybrid powertrain internal combustion engine ice downsizing represent actual trend vehicle technology reduce fuel consumption emission concerning downsizing concept maintain reasonable power level small engines application turbocharging mandatory spark ignited compression ignited engines following aspect possibility couple electric drive turbocharger electric turbo compound recover residual energy exhaust gases becoming attractive demonstrated several studies around world current application championship present paper shows first numerical results research program collaboration universities pisa genoa first study focused evaluation benefits resulting application etc electric turbo compound small twin cylinder engine starting experimental maps two turbines one compressor complete model turbocharged engine created using avl boost one dimension code numerical activity moves whole vehicle powertrain modelling considering three driving cycles two different vehicle configurations order verify effectiveness proposed etc solution results show adoption etc advantageous used conventional turbocharger turbine target optimize overall efficiency one specific operating point ice like case range extended electric vehicles besides etc slightly improve average overall efficiency ice must provide variable power output case conventional hybrid vehicles however major benefits coming etc boost range extension lowest engine rotational speed region possible reduction turbo lag key points parallel hybrid especially conventional vehicles concerning whole vehide powertrain simulation first results show etc improve fuel economy smaller vehicle especially employed urban cycles etc much advantageous case larger vehicle particularly extra urban roads motorways considered elsevier ltd rights reserved
objectives first drug repurposed treatment depression tuberculostatic iproniazid present drugs belonging new classes antidepressants still antimicrobial effects dysbiosis gut microbiota implicated development exacerbation mental disorders major depressive disorder mdd based current interest gut brain axis focus narrative review compile available studies regarding influences gut microbiota behavior depression show antimicrobial effect antidepressant drugs discussion regarding possible contribution antimicrobial effect antidepressant drugs effectiveness resistance included methods search included relevant articles pubmed scielo lilacs psycinfo isi web knowledge results mdd associated changes gut permeability microbiota composition respect antidepressant drugs present antimicrobial effects could also related effectiveness drugs mdd treatment conversely antimicrobials present antidepressant effects conclusion antidepressants antimicrobials present neuroprotective antidepressant antimicrobial effects studies needed evaluate participation antimicrobial mechanisms antidepressants mdd treatment well determine contribution effect antidepressant resistance
simple cost effective synthesis nanomaterials advanced physical chemical properties received much attention researchers interest researchers different disciplines present work report simple one pot electrochemical synthesis poly melamine entrapped gold nanoparticles aunps composite aunps composite prepared single step electrochemical method wherein aunps simultaneously fabricated electrode surface prepared materials characterized various physicochemical methods aunps composite modified electrode used electrocatalyst oxidation catechol due well defined redox behavior enhanced electro oxidation ability towards modified electrodes optimized conditions differential pulse voltammetry dpv used determination dpv response linear concentration ranging detection limit aunps composite modified electrode exhibits high selectivity presence range potentially interfering compounds including dihydroxybenzene isomers sensor shows excellent practicality containing water
article make critical assessment relation online print design focusing graphic language newspaper infographics lot work done area consists adapting print newspaper infographics online versions problem many adaptations losses reading strategy structure online versions offering readers mainly linear reading experience understand fact compare print infographics digital versions analysis layout cognitive load time knowledge computer programming seems crucial editorial design reflect importance layout principle design structure help readers access understand information
trigeneration systems used advantage last years distributed electricity generation systems function growth natural gas pipeline network distribution system tax incentives energy regulation policies typically trigeneration system used produce electrical power simultaneously supplying heating cooling load recovering combustion products thermal power content otherwise would driven atmosphere concerning two small scale trigeneration plants tested overall efficiency evaluation operational comparison first system based iso natural gas powered microturbine second one uses natural gas powered internal combustion engine coupled electrical generator prime mover stack gases machines directed ammonia water absorption refrigeration chiller producing chilled water first next water heat recovery boiler order produce hot water experimental results presented along relevant system operational parameters appropriate operation including natural gas consumption net electrical thermal power production hot cold water production rates primary energy saving index energy utilization factor total partial electrical load operational conditions elsevier ltd rights reserved
present research explored effects cultural affective linguistic variables adult chinese second language learners willingness communicate chinese one hundred sixty two chinese second language learners chinese university answered willingness communicate chinese scale intercultural sensitivity scale chinese speaking anxiety scale chinese learning motivation scale use chinese profile well background questionnaire major findings follows willingness communicate chinese scales significantly negatively correlated chinese speaking anxiety scale positively correlated length stay china chinese speaking anxiety scale powerful negative predictor overall willingness communicate chinese willingness communicate chinese scales followed length stay china chinese learning motivation scale interaction attentiveness chinese proficiency level apparently students willingness communicate chinese largely determined chinese speaking anxiety scale level length stay china mediated variables chinese proficiency level intercultural communication sensitivity level
dual source multi functional heat pump dmhp system adopt air source solar energy provide air conditioning domestic water building year round integration solar thermal collecting system multi functional heat pump system paper presents investigation operation characteristics novel dmhp system various working modes theoretical experimental methods working mode dynamic model proposed validated experimental data verified model switch point air source solar energy identified comparing operation performance different working modes range boundary conditions results indicate performance air source space heating mode superior solar space heating mode ambient temperature degrees solar water heating mode efficient air source water heating mode ambient temperature degrees basis annual performance system different climate conditions reveals dmhp system obtain relatively high cop optimal working strategy whole year especially district cold winter furthermore exergy loss ratio component dmhp system discussed provide reference optimization general dmhp could promising building energy supply system advantage high equipment utilization compact structure full featured research would promote development innovative technology leading significant energy saving carbon emission reduction building sector elsevier ltd rights reserved
one major problem solar cells decrease efficiency due increase temperature operating constant irradiation solar energy combination solar cell thermoelectric generator one methods proposed solve problem paper performance thermo photovoltaic system studied experimentally well numerical simulation experimental part design manufacture test novel thermo photovoltaic system assembly presented results assembled system showed reduction one degree centigrade temperature solar cell investigation increase efficiency obtained comparison given efficiency specified temperature solar cell hybrid assembled system two cooling conditions air cooling water cooling obtained efficiency respectively efficiency single cell radiation condition numerical simulation part photo thermoelectric performance system analyzed two methods evaluation thermoelectric performance used average properties finite element method results simulation also demonstrate increase solar cell efficiency combined system comparison single cell configuration
model assessment integral part many engineering applications analytical numerical mathematical model used predictive purposes approximation real system bayesian approach model assessment requires calculation evidence candidate model considered given available measured data nontrivial task usually attempted offline using stochastic simulation scheme deterministic approximation authors general hardly field structural dynamics investigated online application model assessment current work explores bayesian model assessment online identification scheme joint state parameter estimation particular unscented kalman filter whose computational efficiency widely recognized could integrated single method hierarchical bayesian modeling approach involves two inference levels namely model assessment parameter estimation possibility adding another level within hierarchy noise estimation illustrative example involving several hysteretic candidate models presented demonstrate implementation proposed procedure structural health monitoring applications copyright john wiley sons ltd
dense stereo correspondence challenging research problem computer vision field address poor accuracy behavior stereo matching propose novel stereo matching algorithm based guided image filter modified dynamic programming firstly suggest combined matching cost incorporating absolute difference improved color census transform icct secondly use guided image filter filter cost volume aggregate costs fast efficiently disparity computing step design modified dynamic programming algorithm weaken scanning line effect last final disparity maps gained post processing experimental results evaluated middlebury stereo datasets showing approach achieve good results low texture depth discontinuity areas average error rate strong robustness
spectral clustering makes use spectral graph structure affinity matrix partition data disjoint meaningful groups requires robust appropriate affinity graphs input order form clusters desired structures constructing affinity graphs nontrivial task due ambiguity uncertainty inherent raw data existing spectral clustering methods typically adopt gaussian kernel similarity measure employ available features construct affinity matrices euclidean distance often accurate representation underlying data structures especially number features large paper propose novel unsupervised approach named axiomatic fuzzy set based spectral clustering afssc generate robust affinity graphs via identifying exploiting discriminative features improving spectral clustering specifically model capable capturing combining subtle similarity information distributed discriminative feature subspaces accurately reveal latent data distribution thereby lead improved data clustering demonstrate efficacy proposed approach different kinds data results shown superiority proposed approach compared state art methods elsevier ltd rights reserved
patients diabetes mellitus exhibit increased risk development heart failure occurrence heart failure patients diabetes associated poor prognosis therapeutic strategies reduce cardiovascular morbidity mortality diabetes far mainly focused prevention coronary events recent data suggest early diagnosis heart failure diabetes well specific therapies could major impact prognosis patients article aims provide comprehensive overview epidemiology pathophysiology prognosis heart failure diabetes patients addresses current aspects heart failure therapy diabetes well diabetes therapy heart failure patients
aids devastating deadly disease affects people worldwide like infections comes without warning specifically childbearing women aids face constant psychological difficulties gestation period even though pregnancy may normal healthy women deal uncertainties stress usually accompany pregnancy live reality life threatening disease addition also deal discriminating stigmatizing behaviors environment well known balanced mental state major determining factor normal pregnancy constitutes starting point good quality life even though progress technology medicine rapid infected pregnant women seem missing basic requirement communities seem unprepared uneducated smoothly integrate people societies letting ignorance marginalize isolate patients aforementioned reasons imperative society medical professionals respond provide necessary support advice hiv positive child bearers attempt allay fears relieve distress purpose paper summarize difficulties patients hiv infection deal order survive merge society identify main reasons low public awareness discuss current situation provide potential solutions reducing stigma among hiv patients
lithium diphosphate glasses doped mgo prepared via melt quenching technique samples characterized ray diffraction xrd raman impedance spectroscopy xrd spectra reflected amorphous nature glasses raman spectra show structural network modifications composition variations studied glasses raman spectra studied glasses contain also typical phosphate glasses bands thus band similar assigned symmetric stretching vibrations groups similar attributed symmetric stretching motions non bridging oxygen nbo atoms bonded phosphorous atoms phosphate tetrahedron electric properties investigated using complex impedance spectroscopy frequency range mhz room temperature impedance spectra analyzed terms equivalent circuits involving resistors capacitors constant phase elements cpe constant phase elements cpe used equivalent electrical circuits fitting experimental impedance data conductivity exhibited jonscher universal power law according relation sigma omega sigma omega observed mgo content increases frequency exponent decreases elsevier rights reserved
background variants unknown significance vuss identified brca brca account majority identified sequence alterations notably vuss occur disproportionately people african descent hampering breast cancer bca management prevention efforts population study sought identify characterize mutations associated increased risk bca young age methods study spectrum mutations brca brca enumerated cohort african american women early age onset breast cancer family history breast cancer general triple negative breast cancer improve characterization brca brca variants bioinformatics tools utilized predict potential function variants results using next generation sequencing methods silico analysis variants total brca brca variants comprising unique variants identified patients unique variants one pathogenic frameshift mutation brca metile possibly pathogenic benign vuss genetic epidemiological approaches used determine association variant haplotype phenotypes age diagnosis family history cancer family history breast cancer brca snps associated age diagnosis log additive model log additive model log additive model dominant log additive models respectively log additive model additionally haplotype composed snps found significantly associated younger age diagnosis using linear regression modeling specifically haplotype containing variant alleles associated older age diagnosis conclusions knowing patient brca mutation status important prevention treatment decision making improving characterization mutations lead better management treatment bca prevention efforts african americans disproportionately affected aggressive bca may inform future precision medicine genomic based clinical studies
travelling time central feature episodic memory severely affected among individuals post traumatic stress disorder ptsd two opposite effects vivid traumatic memories unorganized temporality bottom processes non traumatic personal memories tend lack spatio temporal details false recognitions occur frequently general population top processes test effect two types processes bottom top emotional memory conducted two studies healthy traumatized adolescents period life vulnerability emotion particularly high using negative neutral images selected international affective picture system iaps stimuli divided perceptual images emotion generated perceptual details conceptual images emotion generated general meaning material categories stimuli used along neutral pictures memory task two phases encoding recognition populations reported differential effect emotional material encoding recognition negative perceptual scenes induced attentional capture effect encoding enhanced recollective distinctiveness conversely encoding conceptual scenes similar neutral ones conceptual relatedness induced false memories retrieval however among individuals ptsd two subgroups patients identified first subgroup processed scenes faster controls except perceptual scenes obtained similar performances controls recognition task second subgroup group desmonstrated attentional deficit encoding task benefit distinctiveness associated negative perceptual scenes memory performances findings provide new perspective negative emotional information may opposite influences memory normal traumatized individuals also gives clues understand intrusive memories overgeneralization takes place ptsd elsevier ltd rights reserved
scientific applications become data intensive finding efficient scheduling strategy massive computing network based computing systems drawn increasingly attention existing scheduling models assume processors idle beginning workload assignment fact real distributed computing environments processors may still occupied previous assigned workload new load arrives time period busy idle states processor referred release time based fact processors arbitrary release times propose new divisible load scheduling model hybrid time constraints design effective global optimization genetic algorithm solve finally experiment results show effectiveness efficiency proposed algorithm
purpose review familial hypercholesterolaemia inherited disorder low density lipoprotein cholesterol ldl characterised raised cholesterol level birth high risk premature coronary heart disease paper review genetic basis impact clinical presentation recent findings mutations three genes ldlr apob pcsk known cause autosomal dominant mutation found similar patients clinical diagnosis remainder polygenic aetiology likely due inheritance common ldl raising variants cardiovascular presentation management differ patients based underlying genetic factors summary new genotyping methods next generation sequencing provide better understanding genetic architecture
additive manufacturing printing refers new class technologies actively construct products directly digital model future broader applications require cost reduction machines currently products fabricated low end machines fabricated using fused deposition modeling fdm processes suffer issue low dimensional accuracy due multiple error sources properly manage error sources improved prevision paper proposes novel strategy error compensation fdm processes first consecutively attribute dimensional inaccuracy two major error sources affect geometric shape product positioning error extruder shape deformation induced processing error including material phase change variations occur extruder positioning error characterized kriging model modeling shape deformation due processing error follows method developed huang second using error equivalence concept transform positioning error equivalent amount design input error finally adjust design compensate overall shape deviation validate strategy conduct designed experiment shape deviation prediction compensation experimental results successfully demonstrate effectiveness proposed three step strategy manage multiple error sources fdm processes note practitioners present shape deviation product hinders application additive manufacturing extensive industries paper propose plane compensation plan fused deposition modeling fdm process mathematical models built predict deviation shape compensation algorithm derived based model methodology described paper special compensation system developed fdm machine system analyzes measurement specifically designed test products derives compensation plan modifies computer aided design model increase shape fidelity product
previous studies suggest climate change impacts significantly hydro climatic processes within ganges brahmaputra meghna gbm river basin study examines observed climate characteristics potential strengths limitations three global high resolution reanalyses satellite remote sensing products gbm period estimating trends interannual variations precipitation temperature isolating precipitation variations likely associated nino southern oscillation enso indian ocean dipole iod surface temperature trends show widespread warming across basin maximum increase degrees cdecade western nepal southern tibet rainfall changes indicate pronounced decline high rainfall regions northeast india bhutan nepal bangladesh especially basin wide averaged trends show rainfall decline mmdecade june august brahmaputra meghna temperature variability based principal component analysis indicates first mode associated sea surface temperature sst warming arabian sea western tropical pacific ocean second mode appears significantly correlated sst anomalies western eastern tropical indian pacific ocean enso iod events found significantly influence rainfall variability contributing enso iod annual rainfall mainly bhutan nepal bangladesh north eastern india among three reanalysis products european centre medium range weather forecasts ecmwf retrospective analysis era interim modern era retrospective analysis research applications merra climate forecast system reanalysis cfsr era interim merra agrees well observed precipitation temperature data sets cfsr shows least skills representing spatio temporal variations precipitation temperature
human biomonitoring hbm survey four areas affected natural anthropogenic arsenic pollution conducted italy within framework sepias project questionnaire including exploration risk perception regarding environmental hazards access trust information administered subjects stratified area gender age survey designed investigate populations living polluted areas could adopt prevention oriented habits fostered awareness existing risks addition increased knowledge information flows could support researchers identifying recommendations presenting disseminating hbm results study characterizes four areas terms access trust environmental information provides insights influence environmental information food consumption data analysis combined random forest logistic regression approach carried applied variables derived questionnaire order identify important terms aims defined associations tested using fisher exact test assessed logistic regression order adjust confounders results showed perception personal exposure atmospheric water pollution hazardous industries waste hazardous material transportation waste higher geographical areas characterized anthropogenic pollution citizens living industrial areas appeared aware environmental risks confidence environmental non governmental organizations ngos public authorities addition reported insufficient circulation information concerning influence environmental information food consumption high perception personal exposure atmospheric pollution hazardous industries associated lower consumption local fish conclusion different rps information flow patterns observed areas arsenic natural origin industrial contexts findings may useful targeted risk communication plans support risk management strategies elsevier ltd rights reserved
taking rural green building assessment system northwest china research object paper would discuss regional adaptability green building assessment system paper puts forward assessment target facing dilemma development desertification rural buildings northwest china presents seven assessment items energy land resources water resources material resources living quality environmental load social effect methods expert consultation survey technology information analysis basis assessment index system desertification rural green buildings northwest china would put forward
violence increasing worldwide mainly among socially vulnerable groups women elderly people children adolescents addition justice sector many areas workers involved becoming even important addressing violence one area health sector article aims identify creative potential videos aim tackle issues involving domestic violence children categorized based generation age gender search conducted official sites video channels institutions deal child related topics used webqda software conduct analysis reference purposes used generation gender categories collected video campaigns ten analyzed qualitatively upon analyzing complete scenes parts scenes able see inter intra generational inter intra gender violence consequences children videos allowed critical reflections made educational processes training used combat violence children context generations genders
ability automatically recognize human faces based dynamic facial images important security surveillance health independent living domains specific applications include access control secure environments identification individuals particular place intruder detection research proposes real time system surveillance using cameras process broken two steps face detection face recognition identify particular persons first step system tracks selects faces detected persons efficient recognition algorithm used recognize detected faces known database proposed approach exploits viola jones method face detection kanade lucas tomasi algorithm feature tracker principal component analysis pca face recognition system implemented different restricted areas office house suspicious person entrance sensitive installation system works almost perfectly reasonable lighting conditions image depths
recent advances thermoelectric technology made exhaust based thermoelectric generators tegs promising recovery waste heat utilization exhaust based tegs heavy duty vehicles studied work given generated power limited alternator still indispensable improve fuel economy generated electricity must integrated automotive electrical system consumed electrical loads therefore two feasible ways integrating generated electricity automotive electrical system discussed one original alternator works certain conditions thermostat strategy another smaller alternator adopted works together teg cooperative work strategy overall performance efficiency obtained simulation analysis simulation results show methods improve fuel economy former provides better results moreover electrical loads properly modified fuel economy improved simulation results lay solid foundation application tegs vehicles future
possibilities remote sensing techniques field earth surface monitoring protection specifically problems caused petroleum contaminations mapping insufficiently plugged abandoned old oil wells analysis onshore oil seeps described explained methodology analyzing detection potential hydrocarbon contaminations using earth observation area interest slovakia korna czech republic nesyt mainly building calibrating spectral library oil seeps acquisition situ field data asd cropscan spectroradiometers purpose successful building verification hydrocarbon spectral library application hydrocarbon indexes use shift red edge part electromagnetic spectra spectral analysis input data clarified paper described approach could innovate routine methods investigating occurrence hydrocarbons assist mapping locating potential oil seep sites important outcome successful establishment spectral library database calibration data suitable application data classification identifying occurrence hydrocarbons
sparse signal reconstruction ssr problems based compressive sensing arise broad range application fields among called block structured block sparse signals nonzero atoms occurring clusters occur frequently natural signals make block structured sparsity use explicit many block structure based ssr algorithms convex optimization greedy pursuit developed convex optimization algorithms usually pose heavy computational burden greedy pursuit algorithms overly sensitive ambient interferences two types block structure based ssr algorithms may suited solving large scale problems strong interference scenarios sparse adaptive filtering algorithms recently shown solve large scale problems effectively conventional vector sparse signals encouraged facts propose two novel block structure based sparse adaptive filtering algorithms block zero attracting least mean square bza lms algorithm block norm lms lms algorithm exploit potential performance gain experimental results presented demonstrate validity applicability proposed algorithms
moving objectives detection basis application computer vision technology intelligent video surveillance systems many areas wide range applications dynamic context moving object detection presented paper improve pyramid optical flow law combination edge detection moving object detection method first video pre processing applications wavelet threshold remove noise second pyramid optical flow achieve maximum displacement appears moving objectives uses canny edge detection edge image information finally get optical flow information edge characteristics information second value integration morphology follow campaign get accurate target information lab results indicate algorithm real time high versatile good accurately detect moving objectives
vision future pervaded ambient intelligence ami innovative solutions required order facilitate development applications able fulfill real needs users using agents building ami applications lack platforms languages strike good balance flexibility power expression one hand ease use quick deployment hand introduce tatami platform together claim aop language presents suitable solution issues paper presents architecture tatami together brief description two scenarios implemented using platform important technical aspects concerning authors published elsevier open access article license http creativecommons org licenses
design implementation current controlled single stage single phase integrated isolated power factor correction pfc converter presented paper integrated topology reduces number control switches proposed converter advantage low bulk capacitor voltage single control switch hence reduce complexity control cost sub harmonic oscillations produced conventional current controller adding external compensating signal effect oscillations reduced performance converter improved proposed scheme implemented real time tmsf digital signal processor dsp board performance converter verified experimentally simulation different load line conditions proposed converter designed input output operating khz switching frequency experimental results shows dsp based fuzzy controlled single phase single switch integrated pfc converter achieve high power factor satisfies iec european input current harmonic limits class class applications
methods used analyze slope stability commonly based limit equilibrium theory expressed terms factor safety however analysis approaches variability soil parameters model uncertainties becomes necessary paper pre designed reinforcement slope available technical literature chosen probabilistic analysis statistic information parameters found literature numerical simulations done software slope besides parametric analysis done varying coefficient variability unit weight friction angle investigate effect variability reliability slope also contribution water level measured results show relevant variation reliability index parametric analysis indicating importance study furthermore water level decisive impact safety reliability slope lastly reinforcement geotextiles efficient increase safety slopes
article presents single phase series active power filter mitigation load voltage harmonic content maintaining voltage side regulated without support voltage source proposed series active power filter control algorithm eliminates additional voltage source regulate voltage adopted topology coupling transformer used interface series active power filter electrical power grid article describes control strategy encapsulates grid synchronization scheme compensation voltage calculation damping algorithm dead time compensation topology control strategy series active power filter evaluated simulation software simulations results presented experimental results obtained developed laboratorial prototype validate theoretical assumptions within harmonic spectrum limits imposed international recommendations ieee standard
backgroundchronic kidney disease ckd major public health issue early detection may prevent morbidity mortality screening ckd simply assessed using kidney health check khc compilation blood pressure estimated glomerular filtration rate egfr urinalysis khc screening high risk hospital inpatients recommended implementation cost effectiveness unknown aimswe aimed determine proportion patients currently tested components khc acute hospital admission compare estimated costs screening subsequent follow screening programs methodsa retrospective audit conducted consecutively admitted adult patients frequency egfr testing recorded using published data likely costs benefits components khc estimated resultstwo hundred patients median age years range assessed documented egfr representing complete khc total one abnormalities detected egfr min per recorded diagnosis ckd estimated costs opportunistic hospital khc screening current australian screening programs conclusionshospital patients frequently full khc abnormalities detected opportunistic inpatient khc screening would little impact hospital costs may result significant health benefits khc included routine discharge documentation summary glance opportunistic inpatient kidney health check khc screening little impact hospital costs may result significant health benefits khc included routine discharge documentation
whether exposure violence virtual reality media impact users aggressive behaviour controversial issue academic well public debate article summarises programme research conducted adolescents germany presents cross sectional longitudinal evidence association violent media use aggression provides experimental evidence support mediating variables hostile attributional style increased normative acceptance aggression emotional desensitisation might explain pathways media violence use aggression addition presents development experimental evaluation theory based intervention designed reduce media violence use decrease link aggressive behaviour findings discussed context large international body research points causal role violent media use risk factor aggressive behaviour
pilot study examined status master iron regulatory peptide hepcidin peripheral related iron parameters alzheimer disease mild cognitive impairment patients evaluated relationship iron dyshomeostasis amyloid beta beta cognitive assessment tests neuroimaging clinical data frozen serum samples oregon tissue bank used measure serum levels hepcidin ferritin beta beta using enzyme linked immunosorbent assay serum transferrin levels determined indirectly total iron binding capacity serum iron measured percent saturation transferrin calculated study variables correlated patients existing cognitive assessment tests neuroimaging clinical data hepcidin iron related proteins tended higher patients controls reaching statistical significance ferritin whereas beta beta serum levels tended lower patients pure three times higher serum hepcidin levels controls gender differences hepcidin iron related proteins observed patient stratification based clinical dementia rating sum boxes revealed significantly higher levels iron iron related proteins patients upper compared controls suggesting iron dyshomeostasis worsens cognitive impairment increases unlike beta peptides iron iron related proteins showed significant association cognitive assessment tests neuroimaging clinical data hepcidin iron related proteins comprise group serum biomarkers relate diagnosis disease progression future studies determine whether strategies targeted diminishing hepcidin synthesis secretion improving iron homeostasis could beneficial impact progression
background inflammatory chemokine interferon gamma inducible protein kda biomarker associated several conditions objectives study investigated serum concentrations healthy individuals developed acute respiratory infection ari hypothesis serum concentrations correlate ari severity detection viral pathogens study design data come randomized controlled trial measuring effects mindfulness meditation exercise ari clinical trials nct healthy adults ages followed single season ari incidence severity trial ongoing investigators still blinded participant reported ari symptoms nasal swab lavage pcr based viral identification blood samples collected within first ari symptoms serum concentrations measured elisa systems inc quantikine elisa minneapolis ari severity measured using validated wisconsin upper respiratory symptom survey wurss ari episode resolved results serum concentrations ari episodes correlated ari global severity rho concentrations higher ari viral pathogen detected compared viral pathogen detected median iqr iqr influenza infections higher concentrations coronavirus enterovirus rhinovirus paramyxovirus conclusion serum concentration correlates ari global severity also concentration measured early course ari correlates daily severity duration illness symptoms elsevier rights reserved
thermoelectric materials important sustainable development enable direct harvesting low quality heat electricity among conducting polymers attracted great attention arising advantages flexibility nontoxicity easy availability intrinsically low thermal conductivity work novel facile method reported significantly enhance property poly ethylenedioxythiophene poly styrenesulfonate pedot pss films sequential post treatments common acids bases compared prepared pedot pss seebeck coefficients electrical conductivities remarkably enhanced treatments oxidation level significantly impacts property pedot pss films also well tuned controlling experimental conditions base treatment optimal pedot pss films seebeck coefficient conductivity room temperature corresponding power factor enhancement properties attributed synergetic effect high charge mobility acid treatment optimal oxidation level tuned base treatment
study examined associations intimate partner violence ipv pregnancy mother infant bonding failure postnatal depressive symptoms month postnatal study also examined relationships would mediated antenatal depressive symptoms study prospective cohort study investigated effects third trimester pregnancy month childbirth japanese version index spouse abuse isa japanese version mother infant bonding scale mibs japanese version hospital anxiety depression scale hads used measure ipv pregnancy bonding failure infants depressive symptoms pregnancy postnatal period respectively structural equation modeling sem used find associations four variables final path model sem showed good fit data ipv pregnancy associated mother infant bonding failure month postnatal whereas ipv pregnancy significantly associated postnatal depressive symptoms month postnatal addition study demonstrated associations ipv pregnancy mother infant bonding failure postnatal depressive symptoms month postnatal mediated antenatal depressive symptoms results study indicated need interventions ipv psychological health care abused pregnant women prevent antenatal depressive symptoms prenatal health settings interventions perinatal health professionals would help prevent bonding failure infants postnatal depressive symptoms childbirth
novel type short monopole antenna proposed structure consists periodically slotted coaxial line radiating linear polarization structure easily modified addition thin layer dipoles order generate circular polarization number slots along structure periodicity tuning terminating load allow control antenna main beam angle width one advantage proposed design conventional monopoles antenna require ground plane left hand right hand possible design simply inverting symmetry printed dipoles design details annular slotted coaxial line mast antennas given prototypes fabricated characteristics measured simulations measurement good agreement proposed mast antenna compliant requirements digital satellite radio system frequency bandwidth vswr elevation range degrees theta degrees
three dimensional virtual worlds dvw experienced large growth number users used collaboration activities parallel research field computer supported cooperative work cscw developed taxonomies classify systems support collaboration however cscw perspective presents bias towards traditional user interface paradigms whose affordances quite distinct dvw include features spatial environment embodiment dynamics features regarded significant factors research field presence yet opinion well appreciated perspective cscw analysis question ability cscw taxonomies properly describe collaboration characteristics dvw properly mean say dvw bring fore collaboration characteristics fact distinctive collaboration tools impacting collaboration ways seldom found usual groupware yet cscw taxonomies distinguish posit features contemplated cscw taxonomies usefulness taken account development future systems aim support collaboration
neighborhood environments related parenting behaviors turn life long effect children health well activity spaces measure individual routine patterns movement may helpful assessing physical social environments shape parenting study use qualitative data gis mapping four california cities examine parental activity spaces parents described number factors shape activity spaces including caregiving status age children income parental activity spaces also varied times weekends weekdays places adult child specific places knowing best capture study parental activity spaces could identify mechanisms environmental factors influence parenting behaviors child health
small intestinal injury seldom described context child abuse signs symptoms subtle often leading delays diagnosis describe year old boy initially admitted severe blunt abdominal trauma physical child abuse successfully managed nonoperatively child hospitalized several times nonspecific abdominal symptoms diagnostic laparoscopy discovered jejunal stricture proximal jejuno jejunal fistula symptoms fully resolved resection delayed presentation small intestinal injury remain differential diagnosis evaluation persistent abdominal symptoms child prior history physical abuse even imaging studies reveal specific abnormalities
mexico ethinylestradiol ete levonorgestrel lev regularly produced utilized birth control women work tested effect hormones life table demography ltd rotifers anuraeopsis fissa brachionus calyciflorus exposed different concentrations mixed lev ete ratio rotifers additional level calyciflorus also tested effect endocrine disruptors population growth rate fissa results showed significant differences respect control lower concentrations hormones corresponding lev ete among life history variables fissa average lifespan net reproductive rate stimulated mixed hormones lev ete gross net reproductive rates rate population increase per day calyciflorus stimulated higher levels endocrine disruptors
leukotrienes lts class lipid mediators implicated numerous inflammatory disorders caffeic acid phenethyl ester cape possesses potent anti lts activity inhibition lipoxygenase key enzyme biosynthesis lts study describe design synthesis cape analogs radical scavengers inhibitors caffeic esters bearing propargyl allyl linkers caffeoyl aryl moieties respectively synthesized sonogashira heck cross coupling reactions probe effects flexibility aryl substitution inhibition caffeoyl alcohol ethers well caffeoyl aldehyde ketones synthesized elucidate importance ester linkage inhibitory activity tested compounds proved good radical scavengers preliminary anti lts activity screening hek cell models inhibition potential selected compounds determined human polymorphonuclear leukocytes pmnl screened compounds outperformed cape concentration dependent assays pmnl ester dimers along caffeoyl ethers roughly eight seven fold potent zileuton values respectively
fuel cells eliminate pollution caused burning fossil fuels hence proton exchange membrane fuel cell pemfc one promising technological advances future transportation industry key existing challenges fuel cell commercialization performance design vehicle efficiency since analytical model expressing fuel cells characteristics accurate comparison real system performance robust dynamic model fuel cells great importance study aims introduce optimized model pemfc using electric bicycle consists fuel cell battery pack convertor electric motor electric control unit ecu first phase multi fold study analytical model pemfc efficiency compared experimental results obtained electric bicycle result phase showed overall system efficiency maximum fuel cell efficiency confirms fuel cell performance least efficient functioning maximum output power conditions second phase research collected data used developing linear nonlinear regression models resulting model compared artificial neural network used purpose prediction efficiencies compared results show neural network modelling improves accuracy provides promising performance electric bicycle system hydrogen energy publications llc published elsevier ltd rights reserved
paper stated methods education electronic measurement circuits department measurement fee ctu prague specified typically themes applied bachelor master grade study education supported set electronic function units universal laboratory units laboro simulation program multisim
end user development new trend provide tailored services dynamic environments hospitals services facilitate daily work pharmacy personnel also improve self care elder people still related hospital discharged patients paper presents ambient intelligence ami environment end user service provisioning pharmacy department gregorio maranon hospital madrid composed drug traceability infrastructure train ubiquitous application enabling pharmacy staff create execute services facilitating drug management dispensing authors carried case study various experiments different roles pharmacy department gregorio maranon hospital involved activities drug identification dispensing medication administering authors analyzed effort required create services pharmacy staff discharged patients perception ami environment quantifiable benefits reducing patient waiting time drug dispensing
individuals autism difficulties social learning domains typically involve mirror neuron system mns activation however precise role mns development autism relevance treatment remain unclear paper argue three distinct aspects social learning critical advancing knowledge area mechanisms allow implicit mapping learning others behaviour motivation attend model conspecifics iii flexible selective use social learning factors key targets early start denver model autism treatment approach emphasizes social imitation dyadic engagement verbal nonverbal communication affect sharing analysis developmental processes treatment related changes different aspects social learning autism shed light nature neuropsychological mechanisms underlying social learning positive treatment outcomes autism knowledge turn may assist developing successful pedagogic approaches autism spectrum disorder thus intervention research inform debate relations among neuropsychology social learning role mns educational practice autism
high performance interface circuit sigma delta accelerometer low harmonic distortion used many kinds circuit processing techniques presented work multi bit dynamic element matching correlated double sampling electrostatic force feedback linearization circuit used simultaneously order achieve design indicators usage multi bit design operational amplifier opa becomes easier single stage folded cascode amplifier used modulator osr highly reduced difficulty circuit test results indicate chip area power dissipation sampling frequency khz dynamic range system lower snr sndr reach respectively resolution bits referred full scale acceleration cmos process nonlinearity paper realizes approach simplify design interface circuit improve performance
immunomodulatory long term treatment also become standard treatment spondyloarthritides spa including psoriatic arthritis psa however uncertainty exists dose reduction termination treatment remission low disease activity possible reduce medication terminate treatment spa extensive non systematic literature search performed focusing practice guidelines systematic meta analyses clinical trials medicinal long term treatment voluntary medication reduction axial peripheral spa including psa chances drug free remission treatment biologics axial spa psa low however remission state low disease activity reduction cumulative dosage biologics successful cases without significant increase disease activity current state duration remission without comedication nonsteroidal anti inflammatory drugs nsaid extra articular disease manifestations results previous treatment attempts carefully taken consideration elective dose reduction reduction long term treatment individualized decision made jointly patients physicians risk flares especially extra articular disease manifestations needs weighed possible advantages reduced medication maintainenance mediction free disease remission rare spa psa patients carefully selected biologics treatment allow later voluntary termination therapy without least prior cautious attempt dose reduction
article describes design global monitoring system remotely piloted aircrafts using satellite radio gsm datalink final solution aims small general purpose drones weighing less could engaged internet things concept work propose solution drone operation crash monitoring protection flight restricted areas protection urgent low altitude flights emergency flight hours logging system general purpose drones remotely piloted airplanes article describes certification process current aerospace products attempt apply certification process rpas define categories vehicles specify ones system designed next describe data measurement acquisition unit measures flight data transmits ground database real time compare available technologies provide reasoning selected solution specify disadvantages selected technology overcome article provides description material data flow related business model services provide customers finally results system initial testing provided
active filters effective solutions eliminating harmonic pollution improving reactive power presence nonlinear loads unbalanced sources reduce disturbances caused type load propose paper new control strategy shunt active filter method aims improve electrical quantity behavior steady dynamic states reducing installing cost filter eliminating line voltage sensors established direct power control dpc based virtual flux estimation electrical network using switching function table facing disturbances affecting electrical network integrated phase locked loop pll implemented tested new control strategy matlab simulink environment results obtained show effectiveness active filter control algorithm eliminating harmonic currents shows improvement reactive power injected nonlinear loads allowed confirm robustness proposed strategy sharif university technology rights reserved
contribution remote sensing geographical information system gis techniques estimate surface level seismic hazard investigated using topographic gradient maps states tripura mizoram paper addresses vital issue estimation seismic hazards northeast india hazards high risk also high developing site response maps seismic hazard surface acceleration maps difficult obtain near surface soil data site specific data geophysical geotechnical field investigations smaller resolution scale state region country level topographic slope provides reliable proxy rocky materials maintain steep gradient slope compared soft soil deposits paper peak ground acceleration pga bedrock states tripura mizoram india estimated using probabilistic seismic hazard analysis psha considers linear sources events appropriate ground motion prediction equations applicable india authors adopted square root impedance model estimate spectral amplification study area bring hazard bedrock level surface authors classified entire study area site classes categories thereafter estimated spectral amplifications site periods surface level pga amplification maps developed using probabilistic approach considering pga bedrock level results indicate area highly sensitive spectral responses spectral acceleration spectral amplification rather pga american society civil engineers
cancer cachexia multifactorial syndrome characterized body weight loss atrophy adipose tissue systemic inflammation however limited information regarding mechanisms immunometabolic response cancer cachexia male wistar rats inoculated walker tumor cells tumor bearing rats mesenteric meat collected early stage cachexia stage tumor cell injection surgical biopsies meat obtained patients gastrointestinal cancer cachexia lipolysis showed early decrease glycerol release rats relation control followed fold increase rats whereas novo lipogenesis markedly lower incorporation glucose fatty acids rats development cachexia cdb positive rats respectively addition found cachexia stage results similar animals meat patients increased presence inos tnf alpha hsl cells summary translational analysis meat patients animal model cancer cachexia enabled identify early disruption adl turnover subsequent inflammatory response development cancer cachexia henriques serti franco knobl neves andreotti lima guilherme seelaender batista early suppression adipocyte lipid turnover induces immunometabolic modulation cancer cachexia syndrome
purpose purpose paper present new concept multi module electromagnetic launcher pneumatic assist authors focus problem modelling two module electromagnetic launcher consisting coil gun module rail gun module well key problem determining position dependent parameters resistances inductances discharging electrical circuits connected modules special attention paid possibility influencing missile flight via basic controller variation initial voltage values across terminals capacitor batteries supplying current modules design methodology approach analysis electromagnetic launcher based circuit field approach differential equations describing movement missile drawn circuit theory finite element method comsol multiphysic program used determine position dependent parameters module worth emphasising effect saturation resulting curve ferromagnetic part considered magnetic circuit taken account influence initial missile speed adjusted pneumatic assist unit missile velocity also considered illustrated appropriate simulations matlab program findings analysing flight missile along coil gun rail gun modules necessary distinguish three specific stages moveable element fall stage drive stage fall stage one important findings modelling necessary take account three mentioned stages missile movement particular fall stage shown computer simulations laboratory investigations stage plays important role determining time curves decaying currents discharging electrical circuits module module research limitations implications main difficulties related determining influence air drag force upon missile movement especially module well identifying accurate value contact resistances friction force rails missile module practical implications hybrid construction employing propelling units different characters treated promising challenging trend developing launcher structure one significant advantages solution possibility influencing missile velocity flight social implications since first device successfully completed continuous rise interest electromagnetic launchers observed far social technical impact concerned one promising fields interest seem launchers satellites high pressure compressors simulators modelling collisions meteoroids surface earth electromagnetic guns board war ships originality value novel concept developing construction launchers presented paper integrate propelling modules different characteristics create new multi module constructional compact whole designed constructed prototype consists three modules pneumatic drive unit two electromagnetic drive units different principles operation original methodology leading creation effective mathematical model focusing determination position depended parameters presented verified experimental way
methotrexate efficacious immunosuppressant induction maintenance remission crohn disease goal pilot study determine whether total individual methotrexate glutamate levels mtxglu red blood cells correlate disease activity adverse events crohn disease cross sectional study undertaken patients stable dose weekly methotrexate oral subcutaneous clinical disease activity assessed harvey bradshaw index hbi biologic disease activity measured inflammatory markers concentrations individual mtxglu levels measured red blood cells rbcs using high performance liquid chromatography mass spectrometry association observed rbc individual mtxglu total methotrexate glutamate concentrations clinical disease activity hbi score inflammatory markers adverse events although crohn disease patients remission appeared generally higher rbc total longer chain methotrexate polyglutamate mtxglu concentrations compared active disease definitive association rbc mtxglu levels clinical disease activity could established larger longitudinal studies patients diverse disease activity needed establish value mtxglu levels indicators treatment efficacy clinical outcome
stabilizing alkenyl succinic anhydride asa emulsions using fine particles instead cationic starch attracted much attention recent years herein starch nanocrystals sncs made maize starch hso hydrolysis used stabilize asa emulsions fluorescent carbon dots cds made hydrothermally gelatin introduction cds significantly enhance stability reduce droplet size snc stabilized asa water emulsions consequently sizing performance snc stabilized asa emulsion significantly improved increasing snc mass ratio snc stabilized asa emulsions show much better sizing performance starch stabilized asa emulsions achieving best sizing performance snc mass ratio meanwhile morphology snc starch stabilized asa emulsions traced excitation elsevier ltd rights reserved
traditional still dominant approach authoritarianism measures unidimensional construct however past years studies assessed three hypothesized authoritarianism components authoritarian submission authoritarian aggression conventionalism separately aims study verify three correlated factor structure fits data better one factor model analyze distinct effects three dimensions authoritarianism values prejudice total italian citizens responded questionnaire hypothesized structural equation model shows dimension authoritarian submission mainly related openness change conservation values opposition dimension authoritarian aggression characterized self transcendence self enhancement values opposition conventionalism mainly linked traditional values concerns prejudice variable predicted authoritarian aggression theoretical implications concerns conceptualization authoritarianism discussed
study investigated psychological dependence antidepressants patients panic disorder addressed study study carried four psychiatric clinics tokyo japan individuals eligible outpatients aged years older fulfilled diagnostic criteria panic disorder icd assessments included japanese versions severity dependence scale sds self report version panic disorder severity scale pdss quick inventory depressive symptomatology self report eighty four individuals included patients showed psychological dependence antidepressants total score sds multiple regression analysis showed pdss scores illness duration correlated positively sds total scores binary regression model showed absence remission total score pdss longer duration illness increased risk dependence antidepressants approximately one third patients panic disorder receiving antidepressants fulfilled criteria psychological dependence drugs results underscore need close monitoring especially present severe symptomatology chronic course illness copyright wolters kluwer health inc rights reserved
subsampling linear periodically time varying system results collection linear time invariant systems common poles key fact known lifting used two step realization method first step realization time invariant dynamics lifted system computationally step rank revealing factorization block hankel matrix second step derives state space representation periodic time varying system shown extra computations required second step computational complexity overall method therefore equal complexity realization lifted system modification realization method proposed makes complexity independent parameter variation period replacing rank revealing factorization realization algorithm structured low rank approximation yields maximum likelihood identification method existing methods structured low rank approximation used identify efficiently linear periodically time varying system methods deal missing data elsevier ltd rights reserved
big data growing remarkably technological development field business growing trend try find useful information marketing activities enormous data however data analysis needs knowledge data structures programming skills difficult general employees acquire study propose system visualizes relation goods using pos point sales data ids supermarket think analysts pre requisite skills programming understand relation goods using proposal system easily proposal system turns web application able share result analysis using web browser becomes clear proposal system effective result interview evaluation
objective determine reproducibility evaluation sacroiliac joint sij radiographs among readers varying levels experience identify potential drivers disagreement classification among predefined radiographic lesion types methods study sample consisted consecutive patients aged low back pain months duration met assessment spondyloarthritis international society asas definition positive sij magnetic resonance image hla positive spondyloarthritis spa related clinical laboratory feature according asas classification criteria axial spa seven blinded readers musculoskeletal radiologists rheumatologists classified pelvic radiographs according modified new york criteria mny recorded presence absence lesion types sij erosion sclerosis ankylosis joint space widening joint space narrowing reproducibility mny classification among reader pairs assessed potential drivers disagreement identified among lesion types generalized linear mixed logistic regression model served analyze extent discordance lesion type associated discrepant mny classification results mean kappa values percent concordance mny classification reader pairs musculoskeletal radiologists experienced rheumatologist radiologists erosion showed lowest agreement among patients discordant classification gave highest disagreement conclusion reproducibility radiographic sij classification spa inception cohort fair best moderate among readers varying levels experience questioning applicability mny early spa
current study utilized longitudinal self report data sample dual earner working class couples year old children living northeastern united states research questions addressed roles parents gender ideology gendered behaviors predicting children development gender role attitudes hypothesized parents behavior would influential ideology development children attitudes gender roles parents responded questionnaires assessing global beliefs women men rightful roles society work preferences mothers division household childcare tasks division paid work hours job traditionality data collected multiple time points across first year parenthood year follow final time point children completed sex roles learning inventory serli interactive measure assesses gender role attitudes overall mothers fathers behaviors better predictors children gender role attitudes parents ideology addition mothers fathers played unique roles sons daughters acquisition knowledge gender stereotypes findings current study fill gaps literature children gender development family context particularly examining understudied role fathers children acquisition knowledge regarding gender stereotypes longitudinal exploration relationship parents gender ideologies parents gendered behaviors children gender role attitudes
year million determinations high density lipoprotein cholesterol hdl conducted interpreted germany recently acquired data led fundamental reassessment clinical significance hdl review article based selective literature search low hdlaeuroc levels usually indicate increased cardiovascular risk particularly primary prevention epidemiological relationship hdlaeuroc risk complex hdl plays role back transport excretion cholesterol however biological functions hdl dependent protein lipid composition reflected hdlaeuroc concentration composition hdl pathologically altered also exert negative vascular effects compared low density lipoprotein cholesterol ldl hdlaeuroc secondary importance cardiovascular risk stratification calculation ldl hdlaeuroc ratio useful patients low hdlaeuroc levels prompt search additional metabolic inflammatory pathologies increase hdlaeuroc lifestyle changes smoking cessation physical exercise positive effects recommended however hdlaeuroc currently valid target drug therapy
aiminterleukin receptor seem play major role differentiation cells cells induction production activation inflammatory pathways recent studies suggested association polymorphisms bone articular inflammation diseases ankylosing spondylitis rheumatoid arthritis aim study determine association polymorphisms juvenile idiopathic arthritis jia methoda case control study patients jia healthy controls performed samples genotyped eight single nucleotide polymorphisms snps ilr using real time polymerase chain reaction taqman genotyping technique forty two patients healthy controls chosen randomly measure level serum using enzyme linked immunosorbent assay resultsalthough heterozygous genotype showed weak statistically significant protective effect polyarticular subtype none selected snps associated jia overall indeed analysis haplotypes show significant association jia serum level significantly different among patients healthy controls jia subtypes well moreover significant correlation snps serum concentration conclusionthis first study gene iranian patients jia results show strong association polymorphisms jia disease serum levels association seen polyarticular jia larger studies may help clarify role pathway pathogenesis jia
paper describes new class versatile network elements analog signal processing two ports frequency dependent phase shift starts arbitrary value tends towards different still arbitrary value speaking terms complex frequency response plotted polar coordinates characteristics connect two lines segment idea behind concept utilization coupled two terminal devices able keep constant phase shift driving force response signal infinite frequency called constant phase elements passive realizations constant phase elements well proposed network structures based positive second generation current conveyors verified orcad pspice circuit simulator well experimental measurement
simulation crowds demands coping scalability performance issues usually well supported general purpose agent based simulation toolkits side use agent models provides great degree flexibility specification behaviour entities interactions agent architecture presented work addresses types requirements taking advantage characteristics specific problem domain simulation crowds indoor environments several algorithms implemented improve efficiency management high number agents order cope performance processing movements representation time different models supported specify decision making agents order allow rich behaviours agents represent different types entities people sensors actuators illustrated realistic case study evacuation building faculty computer science different types human behaviours modelled kind situations
myeloproliferative neoplasms mpns philadelphia negative class comprise polycythaemia vera essential thrombocythaemia primary myelofibrosis pmf associated aberrant numbers myeloid lineage cells blood case overt pmf development myelofibrosis bone marrow failure produce normal blood cells diseases usually caused gain function mutations kinase jak use drosophila investigate consequences activation jak orthologue haematopoiesis identified maturing haemocytes lymph gland major haematopoietic organ fly cell population susceptible induce hypertrophy upon targeted overexpression jak show jak activates feedforward loop including cytokine like ligand upd receptor domeless required induce lymph gland hypertrophy moreover present evidence mapk signalling plays key role process inducing expression ligand upd interestingly also show forced activation mapk pathway maturing haemocytes suffices generate hypertrophic organs appearance melanotic tumours results illustrate novel pro tumourigenic crosstalk mapk pathway jak signalling drosophila model mpns based shared molecular mechanisms underlying mpns flies humans interplay drosophila jak signalling pathways unravelled work might translational relevance human mpns
background aims smoking affects course inflammatory bowel disease ibd aimed study impact smoking ibd specific costs health related quality life hrqol among adults crohn disease ulcerative colitis methods large cohort ibd patients prospectively followed year using monthly questionnaires smoking status health resources disease activity hrqol costs calculated multiplying used resources corresponding unit prices healthcare costs patient costs productivity losses disease course items hrqol compared smokers never smokers smokers adjusted potential confounders results total patients ibd unknown enrolled smoked baseline disease course severe among smokers smoking associated higher annual societal costs ibd sic confidence interval sic sic sic sic sic never smokers sic sic sic smokers respectively smoking patients generated highest societal costs primarily driven use anti tumour necrosis factor compounds societal costs smoking patients comparable non smokers societal costs ibd patients quitted smoking years inclusion lower patients quitted within past years sic sic sic sic sic sic smoking associated lower hrqol conclusions smoking associated higher societal costs lower hrqol ibd patients smoking cessation may result considerably lower societal costs
backgroundmultidimensional family therapy mdft well established treatment adolescents showing substance abuse antisocial behavior methodthe effectiveness mdft reducing adolescents substance abuse delinquency externalizing internalizing psychopathology family malfunctioning examined means three level meta analysis summarizing effect sizes manuscripts participants resultscompared therapies overall effect size mdft significant albeit small magnitude similar across intervention outcome categories moderator analysis revealed adolescents high severity problems including severe substance abuse disruptive behavior disorder benefited mdft adolescents less severe conditions conclusionsit concluded mdft effective adolescents substance abuse delinquency comorbid behavior problems subsequently important match specific characteristics adolescents extent impairment mdft
excessive traffic urban environments detrimental effects health economy standard living mitigate problem adaptive traffic lights signalling scheme developed tested paper scheme based state space representation traffic dynamics controlled via dynamic programme minimise implementation costs one loop detector assumed link comparative advantages proposed system optimal fixed time control highlighted example results demonstrate flexibility system applied different junctions monte carlo runs developed scheme highlight consistency repeatability results authors published elsevier
paper presents experimental study conducted oil free steam piston expander micro combined heat power systems expander produce electrical power significant range supply temperature degrees pressure bar expander electrical power output exhibits fast dynamic response change working supply fluid conditions reached expander overall isentropic efficiency including electrical generator efficiency empirical model developed order conduct sensitivity analysis system varying working variables supply exhaust pressures rotational speed supply temperature parameters model identified using experimental results sensitivity analysis showed limited increase electrical power output rotational speed rpm reduction power output values beyond rpm also highlighted significant positive impact supply pressure electrical power output negative impact superheating expander overall isentropic efficiency obtained results useful future control expander integrated rankine cycle since fluid expander exhaust steam pressure close bar possible produce heat temperature close degrees sufficient domestic applications heating direct hot water production elsevier ltd rights reserved
recently deep learning gained prominence due potential portends machine learning reason deep learning techniques applied many fields recognizing kinds patterns classification intrusion detection analyses got data monitoring security events get situation assessment network lots traditional machine learning method put forward intrusion detection necessary improvement detection performance accuracy paper discusses different methods used classify network traffic decided use different methods open data set experiment methods find best way intrusion detection
paper provides experimental evidence interaction company earnings information system influences degree honest reporting managers capital budgeting task specifically results show participants overstate cost less manager cost report determines whether firm earns gain loss report affect whether firm earns profit loss firm always earns either profit loss regardless cost report results suggest impact earnings situation degree honesty depends whether firm uses information system improves ability detect misreporting specifically earnings situation less effect degree honesty firm uses information system information system decreases honesty manager report determines whether firm earns profit loss increases otherwise study provides important insights conditions information systems crowd prosocial behavior elsevier ltd rights reserved
previously showed coincident exposure heat shock degrees tnf alpha synergistically induces apoptosis mouse lung epithelium extended work analyzing effects human lung epithelial responses clinically relevant injury cotreatment tnf alpha induced little caspase poly adp ribose polymerase cleavage human small airway epithelial cells cells beasb cells scratch wound closure rates almost doubled beasb cells air liquid interface cultures human bronchial epithelial cells heat shocked immediately wounding microarray qrt pcr immunoblotting showed fibroblast growth factor fgf synergistically induced wounding enhanced fgf expression wounded blocked inhibitors mapk factor hsf knk hsf knockout beasb cells pcr demonstrated fgf expressed two distal promoters wounded cells wound closure beasb cells reduced fgf receptor inhibition fgf depletion exogenous fgf accelerated wound closure absence presence presence exogenous fgf slowed wound closure suggesting increases fgf expression impairs fgf stimulated wound closure frozen sections normal idiopathic pulmonary fibrosis ipf lung analyzed fgf hsp immunofluorescence confocal microscopy qrt pcr fgf hsp mrna levels fold higher ipf normal lung proteins colocalized fibroblastic foci ipf lung conclude signaling may important impact gene expression contributing lung injury healing fibrosis
toxoplasma gondii gondii seropositivity may associated decreased memory older adults investigate association gondii seropositivity memory nondemented older adults obtained serum samples nondemented older adults evaluated alzheimer disease research center washington university louis missouri usa determined gondii seropositivity anti gondii igg antibody titer examined associations memory function controlling socioeconomic status education level age apolipoprotein status associations gondii seropositivity anti gondii igg antibodies memory although support suggesting interaction anti gondii sex seropositive sample inverse relationship anti gondii titer performance selective reminding test overall found little evidence association impaired memory function gondii seropositivity anti gondii igg antibodies sample nondemented older adults elsevier inc rights reserved
signing capability delegation technique multi proxy signature allows signers delegated group produce jointly multi proxy signature behalf original signer widely applied distributed computing currently multi proxy signature schemes standard model achieve strong unforgeablity lightweight computation short length multi proxy signature problems restrict application since many devices limited computation capacity storage space work novel multi proxy signature scheme short length standard model proposed scheme achieve strong unforgeability also short length signature compared three multi proxy signature schemes proposed scheme great advantages three schemes best knowledge proposed multi proxy signature scheme first shortest size whose signature length bits security level bits length dsa
background bright light therapy blt influences regulation melatonin established treatment seasonal affective disorder sad study designed examine efficacy blt seizure control adults focal epilepsy design adults medically intractable focal epilepsy recruited parallel design double blind randomized trial blt add treatment epilepsy methods patients monitored seizure frequency home week baseline period september december participants allocated high intensity light box emitting using automated permuted block randomization grid allocated cosmetically identical box emitting low intensity subtherapeutic dose patient populations groups instructed use box min upon waking every day weeks january march primary outcome measure trial seizure frequency results participants high intensity low intensity completed trial returned adequate data analyses median reduction seizures treatment phase group group patients high intensity condition experienced overall reduction frequency complex partial seizures compared patients used low intensity light box response rates treatment conditions significantly different patients hippocampal sclerosis likely respond blt either intensity patients focal epilepsies risk ratio lower limit upper limit conclusions find significant difference responder rates low high intensity arms trial patterns within data suggest blt may warrant investigation treatment people hippocampal pathology initial findings suggest caution exercised using blt people extra temporal focal epilepsy may result increase seizures elsevier inc rights reserved
skimming flow stepped spillway upstream flow motion nonaerated turbulent boundary layer develops outer edge boundary layer interacts free surface inception point air entrainment herein new experiments performed developing flow region large stepped spillway model step height flow properties developing flow region carefully documented developing boundary layer velocity distributions followed power law step edges detailed velocity pressure measurements showed rapid flow redistribution step edges step cavities application momentum integral equation indicated average friction factor close observed air water flow friction factor suggesting spatially averaged dimensionless shear stress comparable developing flow fully aerated flow regions
depression storage maximum storage precipitation runoff soil surface given slope determined soil roughness agricultural soils largely affected tillage direct measurement straightforward natural permeability soil therefore generally estimated empirical relationships numerical algorithms based roughness indexes height measurements soil surface respectively objective work evaluate performance models using direct reliable measurements agricultural soil reference values study carried experimental microplots measured six situations resulting combination three types tillage carried parallel perpendicular main slope data used reference evaluate four empirical models numerical method longitudinal altitudinal profiles relief obtained laser profilometer infiltration measurements carried tillage largely affected tillage direction highest values found rougher surfaces mainly macroforms cut dominant slope empirical models limited performance numerical method effective even important variability addition correct hydrological management take account type soil tillage affects infiltration rate differently copyright john wiley sons ltd
fast proliferation microgrids integrated power grid several nearby microgrids common benefit coupled multi microgrids mmgs significant stage developing smart grid suitable control structure corresponding control device need proposed mmgs operating efficiently however mostly micrgrid control devices still restricted single microgrid limited application without common design authors develop control devices prodigious popularisation value mmgs based hierarchical control structure according proposed four layer control architecture scheduling layer central control layer integrated terminal layer bottom layer hardware software design suitable mmgs control devices multi time scale communication architecture presented furthermore appearance design interface exploitation introduced well experimental results provided demonstrate validity proposed mmgs control structure devices could contribute large scale application mmgs control devices provide reference mmgs projects
purpose study investigate protective effects mechanisms essential oil zanthoxylum bungeanum pericarp zbeo dextran sulfate sodium dss induced experimental colitis mice zbeo decreased dss induced body weight loss disease activity index colon length shortening colonic pathological damage myeloperoxidase activities production pro inflammatory mediators significantly alleviated zbeo mechanistic analysis showed zbeo inhibited inflammation regulating kappa ppar gamma pathways zbeo also inhibited nlrp activation colitis mice furthermore zbeo contributed maintenance tight junction architecture regulating expression zonula occludens colitis surprisingly treatment zbeo increased levels commensal bacteria containing lactobacillus bifidobacteria reduced escherichia coli levels feces mice results suggested supplementation zbeo might provide new dietary strategy prevention ulcerative colitis
previous research shown violent video game play related aggression aggression related variables contrast less known whether individuals likely others target increased aggression violent video game play present research examined idea effects violent video game play stronger target member outgroup rather ingroup fact correlational study revealed violent video game exposure positively related ethnocentrism relation remained significant controlling trait aggression providing causal evidence experimental study showed playing violent video game increased aggressive behavior effect pronounced target outgroup rather ingroup member possible mediating mechanisms discussed
similarly computer operating systems guarantee safe access memory resources network operating systems shall grant sdn applications reliable access neatly organized flow table resources paper presents architecture controller agnostic memory management system functionalities aim improving flow table usage preventing network misconfigurations implementation perspective work discusses applicability proposed system strategy evaluate current open challenges
paper results layout design circuit topological computer simulation elements analytical microsytem chip silicon insulator soi structures presented elements input cascade basic element operational amplifier ring oscillator based standard bulk cmos technology cmos technology soi structures also polysilicon insulator resistive elements studied wide temperature range elements used regular elements matrix analog digital signal processing integrated circuits initial processing analytical information microsystem chip sensitive elements intellectual sensors microsystemon chip
objective order mitigate childhood obesity evidence influences children health behaviours needed inform new health promotion strategies present study investigated association parental practices child diet body weight status design grade students parents completed health surveys parents asked much encourage child eat healthy foods much personally care healthy eating children diet quality vegetable fruit intake assessed using ffq children heights weights measured determine body weight status mixed effects regression models used determine influence parental responses outcomes interest setting elementary schools across province alberta canada subjects grade students aged years parent results parents reported caring healthy eating encouraging child eat healthy foods least quite lot children whose parents cared encouraged much compared quite lot likely better diet quality less likely overweight children whose parents cared encouraged much compared quite lot scored average points higher diet quality index conclusions health promotion strategies aim high level parental interest encouragement children eat healthy foods may improve diet quality prevent overweight among children
paper presents approach data driven modeling aeroelasticity application flutter control design wind tunnel wing model modeling centered system identification unsteady aerodynamic loads using computational fluid dynamics data adopts nonlinear multivariable extension hammerstein wiener system formulation modal coordinates elastic structure yields reduced order model aeroelastic feedback loop parametrized airspeed flutter suppression thus cast robust stabilization problem uncertain airspeed low order infinity controller computed paper discusses detail parameter sensitivity observability model former justify chosen model structure latter provide criterion physical sensor placement wind tunnel experiments confirm validity modeling approach effectiveness control design elsevier ltd rights reserved
naive central memory lymphocytes infiltrate inflamed gut mucosa inflammatory bowel disease ibd patients homing subsets gut might explained ectopic formation tertiary lymphoid organs tlos containing high endothelial venules hevs aimed evaluate presence hevs tlos inflamed intestinal mucosa newly diagnosed untreated ibd patients relation presence lymphocytes ibd patients healthy controls included prospectively biopsy samples inflamed normal intestine respectively analysed immunohistochemistry lymphocytes blood vessels peripheral lymph node addressin pnad expression meca lymphocyte subsets identified flow cytometric immunophenotyping higher number hevs found inflamed colon patients ulcerative colitis median hev interquartile range iqr ileum crohn disease patients compared healthy controls high density colonic hevs hevhigh associated increased infiltration inflamed gut median iqr cell population compared hevlow patients number colonic follicles higher hevhigh patients median iqr compared hevlow patients controls increased homing lymphocytes inflamed gut tissue ibd patients might facilitated ectopic formation extrafollicular hevs tlos subgroup patients
epidemiological studies implicated fine particulate matter risk factor neurodegenerative diseases neurodevelopmental disorders however underlying molecular mechanisms influences different components remain largely elusive extended previous work investigate role oxidative stress dna hydroxymethylation neuronal pathology found extracts water soluble extracts organic extracts carbon core component differentially caused cell cycle arrest cell apoptosis cell proliferation inhibition neuronal cells effects mechanistically related oxidative stress suggesting toxic compounds adsorbed particles may cause different types brain damages addition organic extracts increased global dna hydroxymethylation gene specific dna hydroxymethylation neuronal genes subsequently interfered mrna expression impairments neuronal progression characterized decreased length neurite reduced mrna expression neuronal markers synaptic markers blocking effects antioxidants demonstrated involvement oxidative stress mediated hydroxymethylation abnormalities induced defects neurite outgrowth synapse formation results first revealed role oxidative stress mediated abnormal dna hydroxymethylation neuronal impairments thoroughly evaluated neurocytotoxicity different components elsevier rights reserved
nowadays systems regarded complex processes develop becoming complex increasing trend makes effective analysis methods inevitable necessities meanwhile matriarchal tools becoming prominent paper tried study work transformation matrix wtm level coupled blocks activities cbas neighboring matrices wtm act information flow interfaces activities shown equivalent state space representation matrices equivalency helps improve analysis method set cbas constituting whole wtm additionally concepts powers adjacency matrices elementary dynamic properties process system modern control theory brought together analyze behavior activities coupled blocks analyzing properties case study five heuristic derived proposed improving process better preference ordering activities effectiveness heuristics tested simple discrete time simulation results show time reduction case study
protein secondary structure describe protein construction terms regular spatial shapes including alpha helices beta strands loops protein amino acid chain adopt regions information supportive protein classification functional annotation structure prediction relevance information scope practical applications cause requirement effective storage processing relational databases widely used commercial systems recent years one serious alternatives honed years experience enriched developed technologies equipped declarative sql query language accepted large community programmers unfortunately relational database management systems designed efficient storage processing biological data protein secondary structures paper present new search method implemented search engine pss sql language pss sql allows formulation queries relational database order find proteins secondary structures similar structural pattern specified user paper show search process accelerated multiple scanning segment index parallel implementation alignment procedure using multiple threads working multiple core cpus
success total knee arthroplasty tka depends many factors position prosthesis vitally important purpose present study evaluate value computer aided establishing lower extremity mechanical axis tka using digital technology total cases patients tka randomly divided computer aided design navigation template group conventional intramedullary positioning group cip three dimensional scanning images hip knee ankle obtained group ray images scans transferred reconstruction software bone model hip knee ankle well modified loading reconstructed saved stereolithographic format reconstruction model mechanical axis lower limb determined navigational templates produced accurate model using rapid prototyping technique tha cip group performed according routine operation scans performed postoperatively evaluate accuracy two tka methods averaged operative time group procedures min shorter conventional procedures min coronal femoral angle coronal tibial angle posterior tibial slope group cip group respectively statistically significant group differences found navigation template produced mechanical axis lower extremity may provide relative accurate simple method tka
random decrement technique rdt based decentralized computing approaches implemented wireless sensor networks wsns shown advantages modal parameter data aggregation identification however previous studies rdt based approaches ambient vibration data based assumption broad band stochastic process input excitation process normally modeled filtered white white noise addition choice triggering condition rdt closely related data communication project research conducted study nonstationary white noise excitations input verify random decrement technique local extremum triggering condition chosen implemented purpose minimum data communication rdt based distributed computing strategy numerical simulation results show proposed technique capable minimizing amount data transmitted network accuracy modal parameters identification
new approach optimized automatic design stator squirrel cage induction motor presented objective develop algorithm design gmsh software automatically differential evolution algorithm reducing cost volume stator materials stator part motor main function generate magnetic field thus interesting research theme since related production cost electric motor solve case study used mode algorithm viultiobjective optimization differential evolution outcome compared nsga algorithm non dominated sorting genetic algorithm discussion limitations advantage proposed design approach concludes paper
many people view religion crucial source morality however experiments total revealed good deeds perceived less moral performed religious reasons religiously motivated acts seen less moral exact acts performed reasons experiments religious motivations also reduced attributions intention responsibility experiments effect fully mediated effect religious motivations perceived morality experiment effects explained different perceptions motivation orientation intrinsic extrinsic across conditions experiment also evident religious upbringing led intuitive moral response experiment effects generalized across religious nonreligious participants viewing religiously motivated good deed people infer actually helping others part side effect motivations rather end thus religiously motivated actors seen less responsible secular actors good deeds helping behavior viewed less moral identical good deeds performed either unclear secular motivations
video games pervasive pastime among children adolescents growing popularity video games instigated debate among parents researchers video game producers policymakers concerning potential harmful helpful effects video games children article provides overview research findings positive negative effects video games thus providing empirical answer question video games good bad article also provides guidelines help pediatricians parents caregivers protect children negative effects maximize positive effects video games
children wealthier families likely health insurance children poorer families average however relationship family income health insurance non linear children near federal poverty line fpl less likely insured children wealthier families obtain health insurance private market poorer families obtain government funded health insurance health insurance dip persisted even medicaid expanded cover fpl one explanation families far poverty line better connected welfare system consequently likely enroll medicaid study uses data current population surveys finds controlling many determinants eligibility forms government assistance likely health insurance relationship family income children health insurance status strictly increasing controlling enrollment welfare programs elsevier ltd rights reserved
objective clinician ability infer patients thoughts feelings critical component high quality care goal article present new test measure ability clinicians called test accurate perception patients affect tappa methods audiovisual clips taken patients actual medical visits patients reviewed videotape visit identify thoughts feelings visit information used extract short audiovisual clips correct answer patient report thought feeling associated clip tappa contains audiovisual clips responded multiple choice format results tappa showed good psychometric properties optimal mean good variance adequate internal consistency strong test reliability convergent validity tests emotion recognition addition test showed predicted better performance female male participants conclusion tappa promises valuable tool research education provider patient relationships quality care practice implications tool testing clinicians understanding patients thoughts feelings may contribute better quality care improved selection training elsevier ireland ltd rights reserved
background patients nonischemic dilated cardiomyopathy dcm may lower risk ventricular arrhythmias compared ischemic cardiomyopathy icm addition dcm identified predictor positive response cardiac resynchronization therapy crt objectives aim study investigate impact additional implantable cardioverter defibrillator crt according underlying heart disease large study group primary prevention patients heart failure methods observational multicenter european cohort study consecutive patients dcm icm history sustained ventricular arrhythmias underwent crt implantation without defibrillator propensity score cause death analyses used compare outcomes results mean follow period months patients icm better survival receiving crt defibrillator compared received crt without defibrillator hazard ratio mortality adjusted propensity score mortality predictors confidence interval whereas patients dcm difference observed hazard ratio compared recipients defibrillators excess mortality patients receive defibrillators related sudden cardiac death among icm dcm conclusions among patients heart failure indications crt dcm may benefit additional primary prevention implantable cardioverter defibrillator therapy opposed icm american college cardiology foundation
nuclear power uprates investments generation capacity enable reactors operate beyond original power limit find owners deregulated reactors likely make investment power uprates moreover deregulation owners boiling water reactors likely choose extended power uprates epus could add percent original power owners pressurized water reactors another type reactors epus technically challenging tend select types uprates add less reactor power deregulation incentivizes reactor owners pursue profitable investments propels make careful investment decisions consistent technological nature plants
property design construction industry main focus sustainability seen affect environmental climate change resource depletion even though building may meet recommended standards overall yet occupants still complain several aspects indoor environmental quality consequently affects health productivity well building occupants spend time indoor space therefore risks air pollutant occurs indoor air dwellings volatile organic compounds paints ventilation others environmental pollutant paper reviews potential health consequences changes climates change whereby developed countries contributed energy consumption greenhouse gas emissions review search publications literature discussing thermal acoustic visual comfort well indoor air quality affects satisfaction indoor environmental quality impacts human health however undertaken review studies highlighted one aspects indoor environmental quality number critical aspects give direct impacts occupants identified subsequently among aspects lighting ventilation acoustics humidity thermal thermal comfort perceived influence overall satisfaction occupants building thus study revealed critical aspects indoor environment contribute improvement well productivity building occupants
ionic polymer metal composite ipmc used various bioinspired systems fish tadpole like robots swimming water deflection smart material results several external factors water distribution concentration ipmc strips variety water concentration surfaces surface conductivity show various deflection patterns paper ipmc strips four initial wetness conditions wet anode surfaces wet cathode surfaces last one submerged deionized water tested even without external excitation strips bend due nonuniform water distribution order understand effects surface conductivity aquatic environment ipmc strip two wires connected two distinct spots used demonstrate power loss due surface resistance three types input signals sawtooth sinusoidal square waves used compare difference input output signals measured two spots thick ipmc strips fabricated employed study sustain drive robot sufficient forces finally aquatic walking robot six degree freedom dof legs designed implemented walked water speed average power consumption per leg leg thigh shank generate dof motions set three legs walked together tripod maintain stability operation
article reports results study investigating efficacy proportional problem solving intervention schema based instruction sbi seventh grade participants included students mathematical difficulties problem solving initial pool seventh grade students larger study teachers students larger study randomly assigned sbi control condition teachers conditions provided instruction topics ratio proportion percent found students sbi classrooms scored average higher counterparts control classrooms posttest delayed posttest administered weeks later given students difficulties proportional problem solving consequences difficulties important contribution research finding provided appropriate instruction students capable enhanced proportional problem solving performance
demand response recent effort improve efficiency electricity market stability power system successful implementation relies appropriate policy design enabling technology paper presents multiagent system evaluate optimal residential implementation distribution network main stakeholders modeled heterogeneous home agents retailer agent able predict control electricity load demand real time price prediction model developed optimal control electricity consumption formulated convex programming problem minimize electricity payment waiting time real time pricing simulation results show peak average power ratio electricity payments significantly reduced using proposed algorithms proposed optimal control algorithms embedded home energy management system make intelligent decisions behalf homeowners responding policies proposed agent system utilized evaluate various strategies emerging technologies enable implementation
objective electroconvulsive therapy ect used treatment several psychiatric disorders decades procedure methodology developed significantly throughout years current ect procedure highly effective treatment useful pharmacotherapy fails able produce quick results life threatening situations mechanism ect exerts therapeutic effects still unclear area active investigation today method article perform review available literature ect mechanisms action focusing specific actions produce therapeutic effect depression also psychotic states schizophrenia catatonia pathologies also giving attention predictors treatment outcome mechanisms acute chronic effects aspects correlated clinical relapse mechanisms superiority pharmacological treatment mechanisms underlying ect side effects results ect produces large number neurobiological effects interact among produce clinical improvement able identify variables allow optimization personalization ect procedures predictors efficacy specific mechanisms action per pathology mechanisms superiority pharmacological treatment mechanisms related acute chronic effects related clinical relapse conclusions studies area may lead better understanding psychiatric disease pathophysiology may help development new improved pharmacological treatments identification mechanisms responsible dramatic responses following single ect session mechanisms related clinical relapse pressing optimization ect treatment
big data visualization relies interdisciplinary research area includes mass data storage retrieval operations analytics security ethics well visualization interaction end users paper reports characteristics big data systems mainly focusing information visualization discusses number methods towards direction analyzing research issues challenges emerge additionally paper discusses new approaches big data visualization context ambient intelligence ami environments highlighting new aspects field respect information presentation natural user interaction furthermore scenario big data visualization ami environments presented aiming bringing surface new potential approaches terms interaction simplification adaptation context use
osteoprotegerin opg powerful inhibitor osteoclast activity plays important role bone metabolism hemodialysis patients relationship opg bone mineral density bmd important remains unclear yet study objective assess opg role related uremic osteoporosis patients cross sectional study realized cohort chronic patients inclusion criteria elderly prevalent patients age years old exclusion criteria previous bone disease previous renal transplant neoplasia parathyroidectomy hormone replacement therapy data regarding demographical clinical characteristics including treatments mineral cardiovascular complications recorded serum opg mineral markers levels measured bmd assessed calcaneus quantitative ultrasound measured broadband ultrasound attenuation speed sound sos stiffness index sti high opg levels associated higher bone mineral density opg sos opg sti malnutrition anemia advanced age correlated bone demineralization males higher bone density parameters females patients treated vitamin bmd increased comparing patients without treatments opg levels directly correlated bone mineral density parameters study confirms critical role opg pathogenesis uremic osteoporosis esrd whether increased circulant opg protect bone loss patients undergoing remains established
technical development wind force mainly combined electrical generator already achieves skillful technique application paper newly developed windchiller directly applies mechanical energy wind force refrigeration instead traditional electrical mechanical energy conversion devise avoids energy loss two fro energy conversion processes wind force electrical energy special finished wind machine applies technique two directions capture wind force faced opposite directions fans design wind turbine compressor transmission system fixed conversion rate used acceleration combination open type reciprocating compressor wind forced chiller built windchiller increases working efficiency comparison refrigerating system indirect connection wind generator refrigerator ignores unstable property wind force strength wind force influences windchiller efficiency stronger wind force larger windchiller efficiency experimental results show newly developed windchiller efficiency agrees pre evaluation achieves high efficiency elsevier ltd rights reserved
pesticide pollution sarajevo public playgrounds important health environmental issue lack information causing concerns amongst general population well researchers since children direct contact surface soils children playgrounds soils much carefully examined furthermore herbicides pesticides get transmitted soil surfaces brought outside urban areas get dispersed following direct applications urban areas infants children health directly affected polluted soils inherent toxicity widespread use different pesticides urban environments playgrounds addition presence chromated copper arsenate cca wood preservative pesticide found soil pollutant playing equipment also documented soil samples playgrounds collected analyzed triazines carbamates dithiocarbamates phenolic herbicides organochlorine pesticides samples determination heavy metals prepared microwave assisted acid digestion findings determined using inductively coupled plasma optical emission spectrometer triazines carbamates dithiocarbamates chlorphenoxy compounds phenolic herbicides organochlorine pesticides organotin compounds detected playground soils determined concentrations respectively found follows determined contents ranges respectively preliminary results raise concerns potential adverse effects herbicides pesticides human health strengthens case preventative protective approach uncontrolled presence herbicides pesticides sarajevo playground soils
node replication attack adversary creates replicas captured sensor nodes attempt control information reaching base station generally compromise functionality network work develop fully distributed completely decentralized schemes detect evict multiple imposters mobile wireless sensor networks mwsns proposed schemes quarantines malicious nodes also withstand collusion collaborating imposters trying blacklist legitimate nodes network hence completeness soundness protocols guaranteed protocols coupled extensive mathematical experimental results proving viability proposals thus making fit realistic mobile sensor network deployments elsevier rights reserved
web environment influence customers voices increasing many companies built online brand communities listening diverse voices customer voc promoting customer engagement information obtained brand communities exploited organizational innovation however voc negative contents could possibly present threats firm online context study develop research model includes types customer expectations opinion leader engagement negative valence voc interaction innovation subsequently empirically validate effects customer expectations interactions among community members organizational innovation using dataset mystarbucksidea com results show effects voc interaction within brand community organizational innovation different depending types expectation voc opinion leaders engagement positively affects interaction among community members moreover negative valence voc affects relationships customer expectations interactions results possible threat within online brand community research results give insight managing brand community analyzing vocs achieve organizational innovation elsevier rights reserved
present study aimed identify association epstein barr virus ebv microrna mirna cellular mirna compromising immune system contributes development burkitt lymphoma present study selected cellular mir focus experiments due previous report differentially expressed observation interleukin receptor virtual target mir ebv bamhi region rightward transcript bart present study confirmed target cellular mir using luciferase assay negative regulatory association mirna mir ebv bart mrna confirmed observation downregulated ebv positive burkitt lymphoma mir upregulated additionally mimics ebv bart mir introduced lymphoma cells found ebv bart mir synergistically reduced expression findings improved current understanding role mir ebv bart target development ebv positive may offer potential novel therapeutic targets treatment ebv positive malignancies
background studies clearly indicate parenting practices relate child externalizing behaviors although mechanisms underlying relation less well understood limited evaluation child routines self regulation relation variables known studies evaluated variables simultaneously objective study examined child routines self regulation serial mediators relations positive negative parenting practices separately child externalizing problems among preschool children methods participants included maternal caregivers preschool children completed measures parenting practices child daily routines self regulation externalizing behaviors results results demonstrated child routines self regulation significant mechanisms negative positive parenting practices relate externalizing problems preschoolers although temporal sequencing upheld respect negative parenting findings offer preliminary evidence child routines may play critical role self regulation development among preschool children turn inversely associated externalizing behaviors conclusion although study needed findings suggest child routines self regulation development may key components incorporate clinically evaluate empirically among intervention programs designed prevent early development behavior problems preschool children
japanese prime minister abe shinzo emerged comeback kid japanese politics second term office widely regarded rare example strong leadership seeks arrest reverse country perceived decline strategy achieve objectives come known abe doctrine represents radical risky shift foreign policy article outlines tenets evolving abe doctrine applies abe administration behaviour mechanisms global governance highly pertinent overlooked example argues although strategic coherent approach global governance emerged abe previously evident expense norm internationalism traditionally shaped japan role
paper provides overview evidence perspective health care professionals hcps relation advance care planning acp people dementia residing long term care settings narrative approach adopted provide comprehensive synthesis previously published literature area systematic literature search identified papers inclusion following review studies four themes identified discussion early integration planning palliative care dementia hcps ethical moral concerns regarding acp communication challenges interacting person dementia families hcps need education training despite evidence hcps recognise potential benefits acp struggle implementation setting greater understanding dementia concept acp required improve consistency practice synthesising existing evidence allow understanding key issues potentially resulting improved implementation practice
paper investigates influence measurement accuracy wind sensors wind energy conversion system wecs performance specifically wind speed direction sensors installed end nacelle three blades horizontal axis wind turbine considered due turbulence wake behind wind turbine blades wind direction measurement highly affected whereas satisfactorily accurate measurement wind speed obtained sensors rear part turbine moreover discrepancy caused rotating rotor wind speed measurement known satisfactory accuracy rotor aerodynamic model thus taken consideration processing data obtained therefore required information mppt yawing control obtained wind speed wecs driven satisfactory performance contrary wecs operation specifically yawing control based direct wind direction measurement sensors installed rear part nacelle may result high discrepancies optimum performance thus combined control technique accurate mppt optimization electrical generator efficiency reliable yaw control provide maximum electric energy production wecs reduction cut wind speed towards low wind speed range several simulation results presented order demonstrate effectiveness operational improvement suggested control scheme
information filtering paradigm clients subscribe server continuous queries express information needs get notified every time appropriate information published perform task efficient way servers employ indexing schemes support fast matches incoming information query database indexing schemes involve main memory trie based data structures cluster similar queries capturing common elements efficient filtering mechanisms exploit clustering achieve high throughput low filtering times however state art indexing schemes sensitive query insertion order adopt evolving query workload degrading filtering performance time paper present adaptive trie based algorithm outperforms current methods relying query statistics reorganise query database contrary previous approaches show nature constructed tries rather compactness determining factor efficient filtering performance algorithm depend order insertion queries database manages cluster queries even clustering possibilities limited achieves percent filtering time improvement state art competitors finally demonstrate solution easily extensible multi core machines
background aging naturally triggers decline cognition result deterioration cerebral circuits thus executive functions efs suffer changes progress mild severe states impairment exercise instead works strategy cognitive enhancement modulating neuronal plasticity regulation bdnf however whether exercise dependent bdnf may improve higher complexity processes efs still studying process results current data exercise dependent bdnf changes aging individuals course cognitive impairment summarized investigate whether exercise regulation bdnf effective pronounce long term changes executive controls exercise dependent regulation bdnf currently undeniable role exercise dependent bdnf tool improvement efs individuals dementia still less clear seldom discussed summary findings indicate limited number studies addressing exercise order discuss parameters related either bdnf executive functioning population conditions narrowing total studies presenting analysis parameters nonetheless positive outcomes bdnf variables displayed populations exposed exercise across studies aerobic exercise shown major source enhancement bdnf dependent executive functioning compared cognitive stimulation moreover effect exercise dependent bdnf domains executive functioning appears occur dose dependent manner aging individuals independently cognitive condition
objectives aim present study investigate organization armstrong nonverbal behavior deceptive statements statements deception proven final aim study show pattern methodology useful tool research doping behavior design observational study focused armstrong micro expressions action units gaze movements head movements drawing observational material different videos excerpts armstrong made doping related statements baseline armstrong deceptive behavior established selecting three video samples fully denied ever taken performance enhancing drugs compared interview conducted oprah winfrey january admitted doping denied specific charges bullying corruption method approach based detection statistically significant hierarchical sequences behaviors time called patterns temporal patterns algorithm implemented theme software determines whether apparently arbitrary events sequentially repeat within specified time interval rate greater expected chance results data analyses allowed identifying distinctive patterns two conditions baseline showed limited number patterns highlighting low level complexity presence stereotyped behaviors oprah video samples number complexity distinctive patterns significantly higher included gaze shifting behaviors conclusions pattern methodology might effective strategy detect nonverbal features deception integrated traditional established practice order improve anti doping measures fight spreading phenomenon elsevier ltd rights reserved
child protection welfare become international issues globalized world ideas childhood upbringing children vary widely depending upon prevailing economic socio cultural religious political contexts dramatic effects way societies value children role acquired state protection advancing well children however remain risk placed risk breakdown extended family systems result urbanization result impaired functioning nuclear families absence kinship safety nets traditional cultural practices place children risk especially girl children poverty creates risks children create specific catastrophic risks girls countries enact visionary laws intended protect children ineffective entrenched social attitudes especially limited resources provided implement enforce ultimate challenge world community must address vision united nations convention rights child realized
nowadays unwanted pregnancy major globe tragedy millions women associated significant direct indirect costs matter individuals society progesterone receptor antagonist steroid mifepristone widely effectively using throughout world medical abortion lesser extent emergency contraception review hope explore role mifepristone contraceptive particularly emergency contraception studies mifepristone also expanding fields endometriosis uterine fibroids furthermore initially considered reproductive medicine investigated psychotic diseases various disorders hypercortisolism glucocorticoid receptor antagonism mifepristone approved suitable patients hyperglycemia secondary cushing syndrome united states food drug administration fda aim article review published reports anti progesterone anti glucocorticoid properties mifepristone clinical agent new insight systematically describing evaluating potential efficiency mifepristone administrated field endocrine neuroendocrine obstetrics gynecology
migraine responsible high rates disability addition associated increased risk cardiovascular disease association limited brain form stroke includes cardiac ischemia increased risk consistently described female population particular migraine aura article reviews current knowledge migraine associated risk cardiovascular disease focus female specific factors elsevier ireland ltd rights reserved
purpose analyze recent trends utilization various noncardiac thoracic imaging modalities medicare population methods medicare part databases reviewed cpt codes pertaining noninvasive imaging thorax selected grouped seven categories ray computed tomographic angiography cta nuclear scans noncardiac mri angiography ultrasound yearly utilization rates per medicare beneficiaries calculated medicare physician specialty codes used determine many studies performed radiologists versus nonradiologist physicians results total utilization rate chest imaging peaked per progressively declined radiologists share thoracic imaging increased among providers total utilization rate chest rose sharply peaked remained steady around recent years cta utilization rate rose progressively utilization rates nuclear chest imaging decreased steadily chest ray rates reached peak declined change largely responsible decline total thoracic imaging conclusion overall thoracic imaging utilization rates declined recent years despite increase use cta decline largely resulted decrease use chest rays american college radiology
purpose review accurate prenatal exposure assessment one major challenges environmental epidemiologic studies variations placental transport make maternal biospecimens unreliable many chemicals fetal specimens collected birth provide information exposure timing prenatal period recent findings skeletal compartment important chemical repository making calcified tissues important measuring exposure decades teeth used estimate long term cumulative exposure metals organic chemicals recently developed methodologies combine sophisticated histological chemical analysis precisely sample tooth layers correspond specific life stages potential reconstruct exposure second third trimesters prenatal development early childhood summary retrospective biomarker precisely measures exposure intensity timing prenatal development would substantially aid epidemiologic investigations particularly case control studies rare health outcomes
examined longitudinal effects family check fcu intervention beginning toddlerhood children peer preference school age specifically sequential mediational model proposed fcu hypothesized promote peer preference higher acceptance lower rejection peers middle childhood positive effects parent child interaction child effortful control early childhood participants low income families female qualities parent child interaction observed structured activities years child effortful control assessed using behavioral tasks years peer acceptance rejection rated teachers years results indicated fcu indirectly predicted peer preference sequentially improving parent child interaction child effortful control findings discussed respect implications understanding mechanisms early parenting focused programs may enhance child functioning across time context
two current trends real time embedded systems multiprocessor architectures partitioning technology enables several isolated applications different criticality levels share computer paper presents real time platform multiprocessor partitioned systems communication requirements also considered paper describes adaptation marte monoprocessor real time operating system xtratum hypervisor multiprocessor intel architecture adaptation makes two contributions ease development process future mixed criticality applications firstly integrates hypervisor technology fully partitioned scheduling multiprocessor environment secondly provides basis interconnect partitioned non partitioned applications via homogeneous communication subsystem copyright john wiley sons ltd
background delivery mobile health mhealth services acceptable mental health consumers however despite benefits accessibility cost effectiveness anonymity ability tailor content individual needs consumer engagement remains hurdle uptake continued use may unsurprising studies examined app content consumer perspective assessed consumer preferences content apps mental health management opportunity examine consumer perspectives exists using naturally generated data publically available google play apple app stores whereas commercial developers routinely use data date depth evaluation within scientific research objective aim study explore consumers consider useful content mental health management apps identify unmet needs understand user expectations mental health apps within context apps bipolar disorder methods publically available english language consumer reviews apps bipolar disorder used data providing total reviews review text coded analyzed using team approach qualitative content analysis results presented forms quantitative summary major minor themes qualitative synthesis key thematic findings results majority reviews symptom monitoring apps qualitative content analysis revealed main themes laudatory talk comments regarding app benefits including helpfulness successful design features reviews unfavorable feedback negative reviews largely concerning unmet needs privacy technical issues potential dangers app use conceptions community referring communities users mental ill health accessed via app community created among app users developers wishlist features app features requested users apps therapy app use within clinical care four minor themes also identified app cost privacy data security comparisons traditional monitoring evidence based mhealth conclusions although mostly positive proportion reviews containing wishlist requests indicates consumer needs adequately addressed currently available disorder management apps consumers value content helpful supportive easy use integrating apps health management clinical care without necessarily considering evidence base clinical effectiveness tool user expectations regarding developer responsiveness needs implications community based participatory research integrated knowledge translation however expectation incompatible current mhealth funding structures
testosterone replacement increasingly offered older men age related decline testosterone levels effects long term testosterone replacement aromatase inhibition glucose homeostasis cardiometabolic markers determine older non diabetic men low testosterone levels men years mean age years serum total randomized double blind placebo controlled parallel group proof concept trial evaluating effects transdermal testosterone gel anastrozole placebo daily months homeostatic model assessment insulin resistance homa primary outcome secondary outcomes included ogis response ogtt fasting lipids reactive protein crp adipokines abdominal mid thigh fat computed tomography outcomes assessed baseline months months absolute changes homa treatment arms group group similar placebo crp fasting lipid levels adiponectin levels significantly decreased group abdominal subcutaneous fat leptin levels significantly lower mid thigh subcutaneousfat reduced treatment arms group group summary proof concept trial changes homa similar three groups effects intervention subcutaneous fat distribution adipokines variable larger efficacy safety trials needed pharmacotherapy considered treatment option low levels older men
conceptually new algorithm sea ice concentration retrieval polar regions satellite microwave radiometry data discussed algorithm design favorably contrasts known modern algorithms design based physical emission model sea surface sea ice snow cover atmosphere system tie points used algorithm calculation expressions derived theoretical modeling design algorithm minimizes impact atmospheric variability sea ice concentration retrieval beside estimating sea ice concentration algorithm makes possible indicate ice areas melting snow melt ponds algorithm simple use complicated time consuming calculations involved cospar published elsevier ltd rights reserved
background different advantages virtually planned guided mandibular reconstructions described functional analyses comparisons conventionally reconstructed patients methods retrospectively analyzed cases mandibular reconstructions involved virtually planned conventional microvascular fibular free flaps occurred april december single center results also compared healthy cohort participants axiographic measurements performed postoperatively uni multivariate regressions analyses performed determine association possible predictor variables functional outcome results operation time hospital stay number osteotomies incidence postoperative temporomandibular joint pain noise tension differ significantly conventional computer aided design computer aided manufacturing cad cam groups mouth opening protrusion laterotrusion also differ significantly significantly reduced compared healthy group univariate analysis showed significant influence postoperative irradiation mouth opening laterotrusion conventional group addition multivariate analysis showed significant influence indication number osteotomies laterotrusion uni multivariate analyses revealed significant influence indication preoperative irradiation number osteotomies protrusion mouth opening cad cam group conclusion cad cam assisted reconstructions mandible give comparable functional results conventional technique functional superiority established nevertheless integration virtual planning guided surgery definitely significant value indicated individually case case
low distress tolerance important component emotion regulation risk factor unhealthy eating identifying factors explain link distress tolerance unhealthy eating advance understanding problematic eating inform prevention treatment obesity eating disorders present study examines pain catastrophizing mediator distress tolerance unhealthy eating nonclinical population received little attention despite risk factor unhealthy eating behaviors distress tolerance scale dts pain catastrophizing scale pcs dutch eating behavior questionnaire debq administered college students female white hispanic evidence significant direct effect distress tolerance unhealthy eating however hypothesized significant indirect mediated effect pain catastrophizing relationship distress tolerance unhealthy eating individuals low distress tolerance reported higher pain catastrophizing result individuals also reported higher levels unhealthy eating findings introduce pain catastrophizing influential variable link distress tolerance unhealthy eating findings suggest reducing catastrophic thinking pain may worthy target intervention reducing unhealthy eating elsevier ltd rights reserved
parental factors linked childhood anxiety hence parental involvement cognitive behavioral therapy cbt anxious children examined however findings consistently show added effects parent enhanced cbt longitudinal investigations scarce long term effects unclear present study families years previously completed one two types cbt treatment limited active parental involvement assessed using semi structured diagnostic interviews diagnostic status years follow compared groups changes diagnostic status across assessment points posttreatment month year follow analyzed within groups diagnostic change month year follow compared groups intent treat analyses revealed significant difference diagnostic status groups year follow nonetheless children whose parents actively participated treatment showed significantly remission month year follow children limited parental participation
present detailed study global bifurcation occuring turbulent von karman swirling flow system statistically steady states progressively display hysteretic behaviour reynolds number increased transition turbulence examine detail hysteresis using asymmetric forcing conditions rotating impellers different speeds high reynolds numbers study sensitivity hysteresis cycle using complementary particle image velocimetry global mechanical measurements forcing nature imposing either torque speed impellers new mean states displaying multiple quasi steady states negative differential responses experimentally observed torque control simple analogy electrical circuits performed understand link multi stability negative responses system compared similar bulk systems understand relevant ingredients negative differential responses studied framework thermodynamics long range interacting systems experimental results eventually compared related problem rayleigh benard turbulence
manufacturing engineering education science technology based subjects traditionally hardest teach online need providing practice hands experiences distance therefore research aims develop leaming system teach manufacturing technology enhance quality scale breadth technological education major results research establish interactive line teaching material computer aided manufacturing courses including cnc coding method cnc simulation propose interactive teaching strategies students learn machining process planning web based learning system integrate multi media virtual laboratory developed interactive leaming system enhance effectiveness machining education web based system enhance students ability extract manufacturing features mechanical drawing either cultivate principle manufacturing process planning developed interactive web based learning system discipline cnc programming cnc machining techniques internet
objective research reported difference woman voice across different stages menstrual cycle review studies singers influence menstruation singing voice enable better understanding changes methods design systematic literature search carried pubmed cinahl scopus cochrane regional electronic databases keywords menstrual cycle voice change singer used different combinations articles discussed effect menstrual cycle singing voice included final review results six studies english language identified included review hormonal variations occur great extent menstrual cycle variations influence voice singers great variability found included studies limited studies carried exploring relationship menstrual cycle singing voice conclusion even though studies included review point toward changes singing voice associated menstrual cycle need studies carried diverse singing populations different outcome measures
study examined social skills russian children males adopted italian families children aged years compared control group children grew biological family evaluation parents children children social competence investigated results showed according parents reports adopted children problems social functioning peers control group along greater propensity use maladaptive behaviors oppositive behavior rule breaking behavior aggressive behavior externalization contrast according children assessments adopted children less aggressive used prosocial behaviors greater extent children raised biological family views parents children children aggressive behavior mutually conflicting finally influence adoption related variables social competence children examined contrary expectations significant relationships social competence age adoption duration institutionalization time spent adoptive family elsevier ltd rights reserved
safety efficacy adalimumab evaluated weeks japanese patients psoriasis routine clinical practice multicenter observational open label postmarketing study primary efficacy measures included psoriasis area severity index pasi dermatology life quality index dlqi patients psoriasis patients psoriatic arthritis psa joint disease activity score das visual analog scale vas pain also evaluated safety assessed based frequency adverse drug reactions adr among patients psoriasis evaluated efficacy significant improvements baseline observed mean pasi dlqi scores weeks furthermore psoriasis patients without psa pasi response rates week week respectively patients psa evaluable effectiveness significant improvements baseline observed pasi das erythrocyte sedimentation rate das reactive protein vas pain weeks adr serious adr reported respectively safety evaluable patients psoriasis unexpected safety findings noted safety profile effectiveness adalimumab treatment psoriasis routine clinical setting expected japanese patients
background asthma wheeze eczema common early childhood cause considerable morbidity generally rates conditions higher high income compared low income countries rates developed nations generally higher less developed countries migration western countries differences risks developing conditions may migrant non migrant may diminish methods convenience sample children white british pakistani ethnicity aged years recruited main born bradford cohort children parents guardians asked report range potential risk factors associations wheeze asthma eczema relationships ethnicity disease outcomes examined using logistic regression adjustment relevant risk factors confounders results ethnic differences doctor diagnosed asthma evident children ethnic origin less likely children pakistani origin likely diagnosis white british origin children although adjustment risk factors difference remained significant ethnic group ethnic differences observed outcomes including wheeze past months severe wheeze taking medications breathing problems conclusions born children traditional risk factors gender family history socio economic status child medical history may stronger risk factors ethnicity familial migration patterns elsevier ltd rights reserved
inbreeding reproduction relatives often impinges health survival resulting offspring inbreeding depression may manifest immunological costs inbred individuals suffer increased propensity disease infection parasites compared outbred conspecifics assess intestinal parasite loads wild banded mongooses mungos mungo vary pedigree inbreeding coefficient standardized multi locus heterozygosity find significant association increased heterozygosity lower parasite loads however correlation stand considering findings may explained local genetic effects linkage genetic markers genes influencing parasite burdens indeed find heterozygosity certain loci correlate parasite load although tentative local effects lost following multiple test correction warrant future investigation determine strength impact also suggest frequent inbreeding within banded mongooses may mean heterozygosity better predictor inbreeding pedigree inbreeding facilitates linkage disequilibrium increasing chances neutral markers representing genome wide heterozygosity finally neither heterozygosity significant influence loads two specific gastrointestinal parasites nevertheless heterozygous individuals benefited reduced overall parasitic infection genetic diversity appears explain variation parasite burdens banded mongoose
human body customization important task computer graphics computer simulation recently existing human body modeling methods may generate distorted model generate human body model match target measurements shortcomings improved paper human body modeling module includes two parts analyzing linear relationship human body shapes measurements human shape modeling according target measurements instead analyzing linear relationship measurements whole human body shapes segment model rigid parts learn mapping body shapes part measurements using method obtain new human body model control target measurements reconstructed human models used infantry battle formation damage simulations
objectivewe compared prevalence receiving depression care adults past year major depressive episodes depressed substance use disorders sud united states depressed counterparts without sud methoddata adults participated national surveys drug use health descriptive analyses logistic regression models applied resultsduring approximately depressed adults sud received past year depression care depressed adults without sud received care overall occurring sud associated decreased likelihood receiving past year depression care risk ratio depressed adults severe functional impairment occurring sud associated decreased likelihood receiving past year depression care depressed men occurring sud associated decreased likelihood receiving past year depression care following depressed adults increased risk receiving depression care without functional impairment without suicidal ideation without physical comorbidities aged male racial ethnic minorities less high school education uninsured never married conclusionsamong depressed adults united states comorbid sud modestly significantly decreases likelihood receiving past year depression care depressed young adults men racial ethnic minorities less educated individuals uninsured adults never married adults also increased risk receiving depression care outreach efforts needed broaden access depression care underserved adults
compelling idea image simple necker cube duck rabbit illusion reveal something person creativity surprisingly multiple examples showing people better discovering hidden images picture also better solving creative problems although idea goes back least century little known two tasks seem different surface related least forms creativity indeed scientific discoveries may require change perspectives order discover novel solution problem possible problems involve similar cognitive process perhaps cognitive capacities switching perspectives ambiguous image begin replicating previous work also show metacognitive similarities sudden appearance hidden images consciousness sudden appearance solutions verbal insight problems show simply observing necker cube improve subsequent creative problem solving lead self reported insights speculate results may part explained conflict monitoring theory elsevier inc rights reserved
multi year national research study examines knowledge perceptions computer science disparities access barriers offering united states first year study surveyed students parents teachers principals superintendents second year surveyed students parents teachers principals superintendents found large majorities respondents groups continue hold positive perceptions computer science work fun exciting socially impactful perceptions remained narrow despite support large majorities groups schools teachers administrators strongly agree top priority school district principals report mixed support key stakeholders principals superintendents describe demand students parents high parents teachers report specifically expressed support education school officials paper also uncovers overall opportunities learn school see increase percent schools teaching computer programming coding even opportunities exist students parents may know half students teachers parents aware learning opportunities community slightly higher percentages students parents aware online opportunities barriers offering schools remain largely unchanged year one study principals continuing cite lack teachers necessary skills prioritization courses related testing requirements reasons offered schools overcome barriers discuss potential opportunity teachers incorporate existing school subjects
ion exchange overoverequivalent sorption tryptophan anionexchange system studied established ion exchange tryptophan background exchange mineral ions better accomplished alkaline solutions form adsorbent overequivalent adsorption amino acid salt containing solution form anion exchange resin results calculating analyzing thermodynamic constants ion exchange non exchange absorption given
individual differences visuo spatial factors play important part environment learning comes mentally representing environments little known visuo spatial factors terms abilities self assessments related individual representations familiar environments group female undergraduates familiar university campus completed object based visuo spatial tasks mental rotation visuo spatial working memory vswm tasks questionnaires self assessed wayfinding inclinations sense direction visuo spatial preferences pleasure exploring environments spatial anxiety spatial orientation performance assessed landmark locating pointing tasks results structural equation modeling showed object based visuo spatial abilities self assessed wayfinding inclinations related spatial orientation performance particular postulated object based visuo spatial abilities rotation indirect effect vswm self assessed wayfinding inclinations support spatial orientation performance spatial anxiety related self assessed wayfinding inclinations overall results show set different individual visuo spatial factors role representation familiar environment elsevier ltd rights reserved
estimating extreme value models high reliability thermal gradients significant task must completed reasonable thermal loads possible thermal stress long span bridges evaluated article generalized pareto distribution based extreme value model combining parameter updating developed describe statistical characteristics thermal gradients long span bridge procedure excluding correlation approach selecting proper threshold suggested prepare samples generalized pareto distribution estimation bayesian estimation capability updating model parameters fusing prior information incoming monitoring data proposed fit generalized pareto distribution based model furthermore gibbs sampling markov chain monte carlo algorithm adopted derive bayesian posterior distribution finally proposed method applied field monitoring data thermal gradients jiubao bridge extreme value models thermal gradients jiubao bridge established extreme thermal gradients different return periods extrapolated results indicate generalized pareto distribution based extreme value model strong ability represent statistical features thermal gradients jiubao bridge bayesian estimation combining parameter updating provides high precision generalized pareto distribution based models predicting extreme thermal gradients predicted extreme thermal gradients expected evaluate design long span bridges
background endotyping chronic rhinosinusitis crs simplified cytokine assays may help direct individualized therapy corticosteroids antibiotics biologics performed unsupervised network analysis endotype crs control subjects using commercially available cytokine chemokine immunoassay methods plex cytokine chemokine array along major basic protein mbp assay performed sinonasal surgical tissue adults subjects defined non crs controls crs nasal polyps crswnp crs without nasal polyps crssnp unsupervised network modeling performed reveal association cytokine chemokine analyte clusters subject groups results network mapping unsupervised clustering revealed analyte clusters subject groups analyte cluster composed helper type markers analyte cluster markers analyte cluster chemokines growth factors subject group devoid crswnp fewer asthmatics associated strongly analyte cluster subject group characterized asthmatics crswnp patients associated analyte cluster subject group associated analyte cluster analyte cluster highest proportion crssnp patients tissue levels mbp eosinophilia computed tomography scores significantly higher subject group groups conclusion unbiased network mapping approach using commercially available immunoassay kit reveals distinct tissue cytokine chemokine signatures endotype crs patients controls signatures prominent even limited number patients may help formulate individualized therapy optimize outcomes ars aaoa llc
objective extent early childhood exposure violent media associated subsequent adverse child functioning remains disconcerting study examine whether preschool child exposure parents generally characterize violent television programming predicts range second grade mental health outcomes methods participants quebec longitudinal study child development months parents reported whether child viewed television shows videos consisting judged violent content results according parents children watched average hours mixed programming per day parent reported child exposure televised violence associated teacher reported antisocial symptoms beta confidence interval emotional distress beta inattention beta lower global academic achievement beta second grade violent televiewing also associated less child reported academic self concept beta intrinsic motivation beta second grade effects remained significant adjusting preexisting child family characteristics baseline child aggression conclusions prospective study suggests risks associated early childhood violent media exposure long term mental health children findings suggesting diffusive relationships early childhood violent media exposure negative socioemotional academic outcomes empirically support notion access early childhood violent television represents threat population health discouraged adult caregivers
city models computer graphics important promoting public participation smart city use solar photovoltaic generation creating city models labor intensive order automate laborious steps proposed new technology integration gis geographic information system proposed integrated system automatically generates building models based building polygons building footprints digital maps show building polygons edges meet right angles orthogonal polygon complicated orthogonal polygon partitioned set rectangles proposed integrated system partitions orthogonal building polygons set rectangles places rectangular roofs box shaped building bodies rectangles paper propose automatically generate building models topped double shed roofs attached arrays sizes positions slopes roof boards roof constructions made clear designing top view side view double shed roof house application example developed system simulate solar photovoltaic generation change city block performing land readjustment changing shape buildings ordinary roof house double shed roof house suitable greater generation simulation reveals double shed roof houses greatly improved solar photovoltaic generation
outline evolutionary embodied epistemological eee account intellectual arrogance proposing people psychologically experience important beliefs valued possessions mental materialism must fight keep ideological territoriality thereby disposing toward nonetheless still vary higher among people taking hostile domineering epistemic stance rejecting reality resisting evidence among taking open deferential one embracing reality respecting evidence variations predicted people standing communion agency circumplex multiple levels analysis social inclusion status dispositional warmth competence behavioral amiability assertiveness using pre validated indices mental materialism ideological territoriality argument evaluation task permitting quantification rational objectivity egotistical bias obtained consistent correlational evidence hypothesized highest agency high communion low validating eee account
determine effectiveness pragmatic health promotion program improve metabolic disorders older workers taiwan conducted week quasi experiment three worksites southern taiwan among workers met inclusion criteria full time workers aged years agreed participate study assigned either intervention reference group according availability participate health promoting activities intervention group received training behavioral modifications improve diet time use stress management physical activity motivational lectures group activities team competitions used improve participants knowledge skills managing health subjects reference group received intervention lifestyle anthropometric biochemical indicators measured baseline end point mixed effects linear models used determine intervention effects intervention significantly lowered body weight intervention reference bmi waist circumference effect biochemical parameters findings suggest workplace based health promotion effective useful reducing risk metabolic disorders older workers taiwan
protein protein interactions ppis essential biological processes play critical role cellular functions development high throughput biological techniques ico methods large number ppi data generated various organisms many problems remain unsolved factors promoted development silico methods based machine learning predict ppis study propose novel method combining ensemble rotation forest classifier discrete cosine transform dct algorithm predict interactions among proteins specifically protein amino acids sequence transformed position specific scoring matrix pssm containing biological evolution information feature vector extracted present protein evolutionary information using dct algorithm finally ensemble rotation forest model used predict whether given protein pair interacting performed yeast pylori data sets proposed method achieved excellent results average accuracy addition achieved good prediction accuracy independent data sets elegans coli hsapiens muscu order evaluate performance method compare state art support vector machine svm classifier get good results
particulate matter contributes increased risk respiratory cardiovascular illnesses cancer preterm birth complications project assessed exposure eastern indonesia largest city air quality comprehensively monitored examined efficacy wearing masks individual intervention effort reduce transit exposures handheld particulate counters used investigate ambient air quality spatial analysis well differences exposure different transportation methods motorcycle pete pete car note means air sample mask efficacy reduce exposure evaluated surgical masks bandanas motorcycle masks monte carlo simulation used provide range uncertainty exposure assessment overall levels elevated compared world health organization hour air quality guideline average levels guideline measurements observed compared cars average motorcycle pete pete exposures four three times higher times higher respectively surgical masks consistent lowering young children vulnerable age group could reach safe dosage even wearing surgical masks individual interventions effectively reduce individual exposures however policy interventions needed improve overall air quality create safer transportation elsevier rights reserved
order locate source signal accurately authorized frequency bands novel primary user localization algorithm based compressive sensing csl cognitive radio networks crns proposed paper comparison existing centroid locating algorithms csl shows higher locating accuracy integrally exploring correlation source signal secondary users sus energy detection first adopted collecting energy fingerprint source signal degree correlation source signal sus reconstructed based compressive sensing determines weights centroid coordinates weighted centroid scheme finally utilized estimate source position simulation results show csl smaller maximum error positioning root mean square error moreover proposed csl algorithm possess excellent location accuracy strong anti noise performance
vaccination rates areas united states decreasing decreases slight significant incidence vaccine preventible disease outbreaks risen vaccination hotly debated public forums paper examine current public framings childhood vaccination better understand parents vaccination opinions behaviors generally polarized pro anti vaccination camps california washington state found instead coalescing stark polarities even falling spectrum across pro anti vaccination divide parents perceptions childhood vaccination highly complex better conceptualized diverse dynamic multidimensional assemblages light argue polarized view vaccination incorrect potentially alienating lay public suggest providers policymakers must begin recognize jagged context dependent equifinal nature parents sort vaccination related information account vaccination decisions order reverse declining vaccination rates united states
low cost portable colorimeter constructed featuring low voltage programmable color light sensor frequency converter cmos bit microcontroller lcd display instrument successfully facilitated introduction application spectroscopy groups middle school high school undergraduate students series tried tested laboratory experiments demonstrate utility capabilities colorimeter developed laboratories help characterize colorimeter also feature challenging problems allow students realize limitations analytical instruments accompanying laboratories enable students determine concentration mixture food dyes using simultaneous equations quantify inorganic phosphate various aqueous based agricultural samples calculate concentration salicylic acid facial acne medication elucidate stoichiometry iron salicylate reaction
satellite radio vehicles normally hampered problem shadowing line sight satellite receiver paper personalized radio concept proposed alternative streaming approach used traditional radio instead transmitting number distinct continuous streams individual audio multimedia files broadcasted received files stored large cache located receiver mobile terminal files sequentially played cache generate service similar traditional radio entertainment programs assembled program may depends user settings depend available files turn depend reception conditions individual user continuous connection satellite receiver therefore longer required instead sufficient ensure enough new files generate attractive program available cache therefore aim reach sufficiently high update rate content cache failure transfer individual file impact audible quality since effect file used assembling program besides robustness approach opens new possibilities terms enhanced services like capability skip repeat part radio program easily integrate additional data services like road weather maps distribution generic html content furthermore approach combined usage satellite systems low link margins already available instance band results low infrastructure costs deployment system together availability new personalized attractive features overview dedicated communication system developed support novel concept presented including status end end demonstrator given copyright john wiley sons ltd
gain better understanding cellular molecular processes important quantitatively analyze motion subcellular particles live cell microscopy image sequences since generally subcellular particles move cell nuclei move well deform important decouple movement particles cell nuclei using non rigid registration methods developed diffeomorphic multi frame approach non rigid registration cell nuclei live cell fluorescence microscopy images non rigid registration approach based local optic flow estimation exploits information multiple consecutive image frames determines diffeomorphic transformations log domain allows efficient computation inverse transformations register single images image sequence reference image use temporally weighted mean image constructed based inverse transformations multiple consecutive frames using multiple consecutive frames improves registration accuracy compared pairwise registration using temporally weighted mean image significantly reduces computation time compared previous work addition use flow boundary preserving method regularization computed deformation vector fields prevents smoothing compared standard gaussian filtering approach successfully applied synthetic well real live cell microscopy image sequences experimental comparison non rigid pairwise multi frame temporal groupwise registration carried
large scale reactor calculations monte carlo including nonlinear feedback effects become reality course last decade particular implementations coupled thermalhydraulic calculations separately developed many different groups numerous codes coupled variety codes system level subchannel computational fluid dynamics work review numerical methods used solve coupled problem particular focus formulation nonlinear problem convergence criteria relaxation schemes used ensure stability iterative process use simple pressurized water reactor pin cell problem numerically investigate stability commonly used schemes problem parameters influence stability lack thereof also examine role running strategy used calculation plays convergence coupled calculation results indicate instability fixed point iterations driven doppler feedback effect underrelaxation used restore stability also observed form underrelaxation could achieved performing coupled iterations without converging fission source iteration performing many iterations histories observed rapid convergence coupled solution relatively small number batches numerical results also showed presence instability fixed point iteration independent stochastic noise simulation
background langerhans cells lcs epidermis resident dendritic cells sense mediate stimuli skin outside world participate various skin diseases playing either pro inflammatory regulatory roles however exact function lcs pathogenesis psoriasis remains unclear conclusions previous studies controversial objectives explore role lcs mouse model imiquimod imq induced psoriasis like dermatitis using langerin diphtheria toxin dta mice constitutively deficient lcs methods imq aldara painted skin mice produce psoriasis like dermatitis inflammation evaluated gross ear thickness histopathology flow cytometry cytokine production bone marrow transplantation fluorescein isothiocyanate tracing applied access migration lcs results severity imq induced dermatitis langerin dta mice significantly lower wild type mice evidenced decreased level ear thickness inflammatory cell infiltration gamma delta cells neutrophils inflammatory cytokine expression tumor necrosis factor alpha application imq lcs expanded epidermis showed increased expression migrated draining lymph node within lcs lymph node application imq expressed increased level chemokine receptor conclusion lcs activated upon application imq promoted inflammatory responses psoriasis like dermatitis japanese society investigative dermatology published elsevier ireland ltd rights reserved
year old mare presented investigation month history blepharospasm eyelid swelling corneal edema ocular discharge right eye ophthalmic examination confirmed mucopurulent ocular discharge conjunctival hyperemia dry dull appearance cornea schirmer tear test results confirmed absence tear production min consistent keratoconjunctivitis sicca treatment topical cyclosporine resulted improvement clinical signs episcleral cyclosporine implant placed standing sedation days initial presentation examination days post operatively confirmed mare tear production right eye improved clinical signs observed topical medications gradually discontinued examinations performed months postsurgery showed recurrence clinical signs adverse effects implant knowledge first report use cyclosporine implant management kcs horse highlights potential effective alternative therapy management kcs horses
background sleep disorders prevalent childhood causes much discussed parental behavior seems special influence child sleep method review focuses correlation sleep disorders childhood sleep related parenting behavior ten studies included collected family data primarily self evaluation parents age children varied zero five years results results included studies evince active soothing child spatial proximity positively correlated sleep problems assumed parental behavior lessens conation child develop reassurance strategies contrast autonomy promoting strategies emotional availability bedtime routines soporific effects improve quality sleep child results discussed regard practical importance conclusion complex system child sleep consists sleep related parenting strategies includesmany factors
sports injuries major issue medicine surgery especially orthopedics since classical antiquity era century progress innovations changed general concept treating injuries forever purpose review show innovations surgery century changed rationale treating sports injuries historical review present innovations concerning fracture treatment spine injury treatment anterior cruciate ligament reconstruction related sports injuries addition present record surgical techniques pioneer surgeons first used
development analytical methods respond emerging need perform rapid situ analyses human metabolic pathways hmps demonstrates disposable screen printed electrodes spes alternative traditional tools kynurenine pathway one important hmps increased production kynurenine kyn main catabolite tryptophan trp degradation involved immuno editing process supporting cancer cells escaping human immune system current study demonstrate development screen printed potentiometric immunosensor vitro evaluation trp consumption kyn production controlled cancer cells response activated lymphocytes engineer immunosensor uniform layer carboxylated multiwall carbon nanotubes mwcnt deposited gold screen printed electrode auspe afterwards monoclonal antibody mab specific kynurenine covalently conjugated mwcnt modified auspe engineered immunosensor examined monitoring trp consumption kyn production metastatic calu nci nonmetastatic hepg cancer cell lines without applying preparation separation steps trp kyn immunosensor offers improved limit detection kyn trp detection respectively broad linear range detection lrd kyn trp detection however immunosensor successfully used situ analysis kyn produced immuno editing process cell culture media could reveal trp consumption kyn production highly metastatic cancer cells significantly higher nonmetastatic hepg cancer cells owing screen printed nature kind biosensors capability integrated lab chip loc microfluidics micro total analysis systems
majority human neuroscience research focussed understanding functional organisation within segregated patches cortex ventral visual stream associated detection physical features faces body parts whereas theory mind network associated making inferences mental states underlying character whether someone friendly selfish generous date however largely unknown distinct processing components integrate neural signals using functional magnetic resonance imaging connectivity analyses investigated contribution functional integration social perception scanning participants observed bodies previously associated trait based neutral information additionally independently localised body perception theory mind networks demonstrate observing someone cues recall stored social knowledge compared non social knowledge node ventral visual stream extrastriate body area shows greater coupling part theory mind network temporal pole results show functional connections provide interface perceptual inferential processing components thus providing neurobiological evidence supports view understanding visual environment involves interplay conceptual knowledge perceptual processing
number metagenomic studies conducted year growing dramatically storage analysis big data difficult time consuming interestingly analysis shows environmental human metagenomes include significant amount non annotated sequences representing dark matter established bioinformatics pipeline automatically detects metagenome reads matching query sequences given set applied tool detection sequences matching large giant dna viral members proposed order megavirales virophages total environmental human metagenomes approximate terabase collected processed stored bioinformatics server addition nucleotide protein sequences megavirales representatives including giant viruses amoeba virophages collected pipeline generated scripts written python language entitled digger metagenomes previously found contain megavirus like sequences tested controls digger able annotate metagenome sequences best matching giant viruses sequences often found similar phycodnavirus mimivirus sequences included reads related recently available pandoraviruses pithovirus sibericum faustoviruses compared tools digger combined stand alone use linux windows operating systems user friendly interface implementation ready use customized metagenome databases query sequence databases adjustable parameters blast searches creation output files containing selected reads best match identification compared metavir reference tool viral metagenome analysis digger detected true positive megavirales related reads control metagenome present work shows massive automated recurrent analyses metagenomes effective improving knowledge presence prevalence giant viruses environment human body
article determines natural frequencies vibration corresponding mode shapes suspension bridge varying bending stiffness cables examines variations occur characteristics respect parametric changes bridge single span suspension steel footbridge flexible cables selected initial model used studying dynamic characteristics suspension system help finite elements method parameter studies bridge model presented vibration characteristics studied function structural material parameters flexural stiffness cable mass density structural components generally found bending stiffness main cable contributes considerable effect natural frequencies type suspension system simplified expression predicting natural bending frequencies suspension bridge taking account bending stiffness cable developed application first step design process
electric motor pump prototype compact structure developed testing system prototype established obtain testing data noise efficiency rotational speed compared performance electric hydraulic power unit noise level prototype maximally decreases volumetric efficiency nearly higher delivery pressure rising mpa mpa however total efficiency prototype lower due lower rotational speed oil immersed loss aiming noise abatement decline efficiency cfd ansoft used analyze suction flow field main pump rotational speed key factors impact noise efficiency prototype presented research results show adopting charging effect measure setting centrifugal charging pump inlet main pump prevent cavitation noise caused insufficient oil suction main pump electrical resistance squirrel cage rotor great impact rotational speed impacts efficiency finally improved virtual prototype improved rotor presented increase total efficiency
research assess effectiveness glass solar chimney wall open frame gscw compare one layer glass wall olgw thailand results showed use gscw reduce inside temperature compared olgw around annually providing heat transfer outside well limiting relative humidity protects occurrence fungi cause allergies research also found gscw results less energy consumption compared olgw addition five times cheaper insulation glass payback period gscw years questionnaire results satisfactory proved gscw good practice pleasing design providing significant energy savings testing hydroponic cultivation gscw house also showed satisfactory growth lack pests resulting controlled temperature humidity protection elements tropical climate thailand gscw suitable design reduction energy consumption sustainable architecture practical application research provides helpful information glass solar chimney wall open frame owners developers adopting energy efficient building sustainable energy conservation tropical country like thailand glass solar chimney wall open frame suitable design best alternative saving energy global environmental conservation building industry
designing efficient transmission mechanisms advanced satellite networks demanding task requiring definition implementation protocols architectures well suited challenging environment particular transport protocols performance satellite networks impaired characteristics satellite radio link specifically long propagation delay possible presence segment losses due physical channel errors level impact performance depends upon link design type constellation link margin coding modulation operational conditions link obstructions terminal mobility weather conditions etc address critical aspects number possible solutions presented literature ranging limited modifications standard protocols tcp transmission control protocol completely alternative protocol network architectures however despite great number different proposals perhaps also general framework appears quite fragmented compelling need integration research competences efforts actually intent transport protocols research line within european satnex satellite network excellence project stemming authors work project paper aims provide reader updated overview possible approaches pursued overcome limitations current transport protocols architectures applied satellite communications paper possible solutions classified following categories optimization tcp interactions lower layers tcp enhancements performance enhancement proxies pep delay tolerant networks dtn advantages disadvantages different approaches well interactions investigated discussed taking account performance improvement complexity compliance standard semantics analysis emerges dtn architectures could integrate efficient solutions categories inserting new rigorous framework innovative architectures therefore may represent promising solution solving important problems posed transport layer satellite networks least medium long term perspective copyright john wiley sons ltd
graphene two dimensional materials received considerable attention regarding potential applications nano electronics report top gate nonvolatile memory field effect transistors fets different layers mose nanosheets channel gated ferroelectric film conventional gate dielectric fets replaced ferroelectric thin film provides ferroelectric polarization electric field therefore defined fet poly vinylidene fluoride trifluoroethylene vdf trfe used gate dielectric among devices mose channels different thicknesses device single layer mose exhibited large hysteresis electronic transport write erase ratio displayed excellent retention endurance performance possible mechanism device good properties qualitatively analyzed using band theory additionally comprehensive study comparing memory properties mose channels different thicknesses presented increasing numbers mose layers found cause reduced memory window however mose thickness yielded write erase ratio results indicate based fet structure combination two dimensional semiconductors organic ferroelectric gate dielectrics shows good promise future applications nonvolatile ferroelectric memory
deese roediger mcdermott drm task false memory paradigm subjects presented lists semantically related words nurse hospital etc encoding delay subjects asked recall recognize words recognition memory version task subjects asked whether remember previously presented words well related never presented critical lure words doctor typically critical word recognized high probability confidence false memory effect robustly demonstrated across short immediate min long delays encoding memory testing strength using task study false memory simplicity short duration encoding retrieval components task occur session entire task take little min however although drm task widely considered false memory paradigm researchers consider drm illusions based activation semantic memory networks brain argue semantic gist based false memory errors may actually useful scenarios remembering forest trees remembering word list doctors even though actual word doctor never presented study remembering gist experience instead along individual details arguably adaptive process task provided great deal knowledge constructive adaptive nature memory therefore researchers use caution discussing overall reach implications experiments using task study false memory drm memory errors may adequately reflect false memories real world false memory eyewitness testimony false memories sexual abuse
misconception programming early stages learning programming computer science minors researches field revealed lack problem solving skills considered one prominent shortcomings novices deal exacerbated language syntax novices employ flowchart based intelligent tutoring system fits proposed research aimed introducing early stages learning programming put record straight students prior knowledge programming target audience research order support novice programmers beginning programming bayesian network approach applied mainly decision making handle uncertainties knowledge level students use bayesian network take full advantage inference engine providing users various guidance described paper therefore proposed system provides users dynamic guidance recommend learning goals recommend options flowchart development generate appropriate reading sequences additionally proposed system architecture components elaborated future work evaluate fits conducting experimental study using novices
work describes system automatic generation full fledged api layers rdf schemas providing whole set object oriented functionalities retrieve store edit delete corresponding data semantic triplestore layers system capable producing range underlying domain model resulting classes data properties object properties input schema related lower level data source access components higher level facades web service interfaces immediately operational used box development purposes either stand alone components integrated external applications user friendly graphical interface allows easy configuration customization generation process suit specific development needs configured execution generation process takes place almost instantaneously bringing full set api components matter seconds thus dramatically saving design development time effort experimentation system carried within context funded research project featuring large semantic schema significant portion represented learning model specifically engineered used plethora learning solutions nevertheless system generic enough employed variety applications relying upon semantic schemas data
zero wear considered wear within limits surface topography component honed cylinder liner surface composed plateaus relatively deep valleys paper two scale homogenized mixed lubrication wear model established study zero wear process cylinder liner order consider plateau roughness valleys separately local global scales honed surface firstly decomposed plateaus valleys morphological filtering approach based two scale homogenization technique homogenized mixed model developed characterize lubrication properties contact severity piston ring liner system basis cylinder liner zero wear process divided two stages first stage running plateau component local scale second stage wear valley component global scale local scale influence plateau component running homogenized flow factors contact stiffness studied global scale influence valley component wear lubrication properties load carrying capacity contact force friction coefficient stu died experiments conducted reciprocating tester experimentally measured friction coefficient wear depth shown good agreement simulation results results showed two scale homogenized mixed lubrication wear model developed paper well predidt cylinder liner zero wear process elsevier rights reserved
purpose frailty functional status emerged significant predictors morbidity mortality patients undergoing cancer surgery articulate impact value quality per cost compared perioperative outcomes expenditures according patient function older adults undergoing kidney cancer surgery materials methods using linked seer surveillance epidemiology end results medicare data identified elderly patients kidney cancer treated nonablative surgery quantified patient function using function related indicators claims indicative dysfunction disability measured day morbidity mortality resource use cost using multivariable mixed effects models adjust patient hospital characteristics estimated relationship patient functionality treatment outcomes expenditures results patients identified function related indicator count greater respectively surgical complications vary patients indicators often experienced medical event geriatric event died within days surgery compared patients baseline dysfunction patients utilized significantly medical resources amassed higher acute care expenditures conclusions kidney cancer surgery patients poor functional health face eventful medical recovery elevated cost indicating lower value care greater consideration frailty functional status treatment planning transitions may represent areas value enhancement kidney cancer urology care
obstetric hemorrhage bring significant challenges obstetrician anesthestiologist optimal management requires systems based multidisciplinary intraprofessinal approach implementation leadership cornerstone successful hemorrhage management national partnership maternal safety recently released patient safety bundle maternal hemorrhage bundle lists resources implemented every delivery unit country optimize readiness recognition response reporting systems learning obstetric hemorrhage anesthesiologists expert resuscitation systems based response help lead bundle implementation clinical teams responding obstetric hemorrhage
social factors health behaviours direct effects substances contribute poor oral health restricted access dental services experienced people dependent drugs alcohol admission inpatient withdrawal management provides opportunity intervention promote oral health effective must acceptable patients support intervention design examined patients views oral health practices treatment access appropriateness health promoting intervention context given paucity knowledge area employed qualitative approach data collected semi structured interviews inpatients public specialist alcohol drug unit australia september analysis employed framework approach participants wanted good teeth diligently attended oral healthcare sought assistance emergencies participants knowledge services limited practical affective barriers hindered access none recalling attention oral health admission support strong incorporation oral health inpatient assessments participants wanted information impact substances oral health oral hygiene practices provided various formats facilitated referral non judgemental affordable treatment patients regarded promotion oral health inpatient context important relevant acceptable support respect different knowledge practices motivations oral health recovery patients addressing practical affective barriers dental services require collaboration drug alcohol dental services focus research
diffuse intrinsic pontine glioma dipg rare often fatal childhood brain tumor remains major therapeutic challenge investigators funded dipg collaborative philanthropic partnership among private foundations launched international dipg registry idipgr advance understanding dipg comprised comprehensive deidentified linked clinical imaging histopathological genomic repositories idipgr uses standardized case report forms uniform data collection serial imaging histopathology centrally reviewed idipgr neuro radiologists neuro pathologists respectively tissue genomic data cell cultures derived autopsies coordinated idipgr available investigators studies approved scientific advisory committee april december patients diagnosed dipg enrolled participating institutions canada australia new zealand radiology repository contains studies patients pathology repository contains tissue patients another samples available submission fresh dipg tissue seven autopsies sent investigators develop primary cell cultures bioinformatics repository contains next generation sequencing data tumors nine projects using data tissue idipgr principle investigators around world underway idipgr successful alliance among philanthropic agencies investigators developed maintained highly collaborative hypothesis driven research infrastructure interdisciplinary translational projects dipg improve diagnosis response assessment treatment outcome patients
neurochemical target cannabinoids interact global effects behavior brain noradrenergic circuitry acute repeated administration cannabinoid receptor synthetic agonist capable increasing multiple indices noradrenergic activity includes cannabinoid induced increases norepinephrine release medial prefrontal cortex mpfc desensitization cortical alpha adrenoceptor mediated effects activation fos brainstem locus coeruleus noradrenergic neurons increases anxiety like behaviors present study sought examine adaptations adrenoceptor expression function conditions cannabinoid receptor type cbr deletion using knockout mice compare wild type controls electrophysiological analysis alpha adrenoceptor mediated responses mpfc slices mice showed clonidine induced adrenoceptor mediated increase mpfc cell excitability coupled increase input resistance contrast cbr mice showed alpha adrenoceptor mediated decrease mpfc cell excitability examined protein expression levels alpha beta adrenoceptor subtypes mpfc well expression locus coeruleus mice deficient cbr alpha inadrenoceptors exhibited significant decrease expression levels cbr mice compared mpfc significant increase observed better define whether cortical neurons express alpha adrenoceptor cbr mpfc utilized high resolution immunoelectron microscopy localized alpha adrenoceptors knock mouse expressed hemoagglutinin tag downstream alpha adrenoceptor promoter although alpha adrenoceptor often identifiedpre synaptically observed localization cbr alpha adrenoceptors post synaptically mpfc neurons finally using receptor binding confirmed prior results showing alpha adrenoceptor unchanged mpfc following acute chronic exposure synthetic cannabinoid receptor agonist win increased following chronic treatment followed period abstinence taken together data provide convergent lines evidence indicating cannabinoid regulation cortical adrenergic system elsevier inc rights reserved
emotional memories vivid lasting necessarily accurate conditions emotion even increases people susceptibility false memories review addresses emotion leaves people vulnerable misremembering events recent research suggests pregoal emotions experienced goal attainment failure hope fear narrow scope people attention information central goals narrow focus impair memory peripheral details leaving people vulnerable misinformation concerning details contrast postgoal emotions experienced goal attainment failure happiness sadness broaden scope attention leaving people resistant misinformation implications legal contexts emotion related errors eyewitness testimony discussed
purpose study examine whether scores widely used measure hostilitythe buss durkee hostility inventory bdhi change measure predicted sexual recidivism sample adult male incarcerated sexual offenders pre posttreatment scores simple difference scores clinically significant change examined majority participants functional scores bdhi prior treatment dysfunctional pretreatment scores majority remained unchanged higher posttreatment scores assault verbal hostility subscales significantly predicted sexual recidivism remaining pre posttreatment scores well change scores classifications significantly predict sexual recidivism findings suggest assault verbal hostility subscales may useful predicting sexual recidivism clearly consistent notion bdhi assesses dynamic risk factor sexual recidivism due number limitations current study however rigorous research needed firm conclusions drawn
paper presents fast novel method determine optimal capacity battery hydrogen system grid connected photovoltaic system based required grid dependency minimum levelized cost energy lce calculated weather data locations throughout japan years considering different sizing battery hydrogen system based results relationship capacities devices weather parameter established results show depends annual total solar insolation devices capacities well empirical formula examined different location japan proposed calculation agrees well obtained real year weather data shows great advantages conventional method simplicity calculation time addition optimal capacity system obtained directly formula objective function lce elsevier ltd rights reserved
notch pathway found activated glioblastomas gbms underlining importance notch formation recurrence gbm study notch inhibitory peptide dominant negative maml dnmaml conjugated elastin like polypeptide elp tumor targeted delivery elp thermally responsive polypeptide actively passively targeted tumor site localized application hyperthermia complex modified addition cell penetrating peptide synb improved cellular uptake blood brain barrier penetration synb elp dnmaml examined cellular uptake cytotoxicity apoptosis cell cycle inhibition inhibition target genes expression synb elp dnmaml inhibited growth cells inducing apoptosis cell cycle arrest especially presence hyperthermia hyperthermia increased overall uptake polypeptide cells enhanced resulting pharmacological effects dnmaml showing inhibition targets notch pathway hes hey results confirm dnmaml effective notch inhibitor combination elp may allow thermal targeting synb elp dnmaml complex cancer cells avoiding dangers systemic notch inhibition
people life questionnaire piml one available self report measures assessing children representations relationship attachment figures parents peers middle childhood current study presents validation studies piml sample portuguese children aged years adolescents aged years original factor structure composed second order factor attachment three first order factors trust communication alienation confirmed scales parents attachment peers attachment sample children replicated sample adolescents using confirmatory factor analyses portuguese version piml showed adequate internal consistency correlated expected measures intrapersonal interpersonal functioning internalizing externalizing problems prosocial behavior quality life self compassion emotion regulation strategies piml proved psychometrically robust measure children representations relationships parents peers representing important advance measurement attachment middle childhood
combined experimental computational study transfer transparent index matched silica particle inks two flat plates presented gravure printing applications influence printing speed initial ink droplet size ability accurately transfer ink printing process explored systematically smooth interface volume fluid simulations show trends ink transfer observed experiments wide range printing speeds inks different silica particle loadings calculations indicate ink droplets characteristic dimensions vicinity particular interest gravure printing applications ink transfer improves significantly due diminishing effect gravity increased importance capillary forces small length scales american institute chemical engineers aiche
paper investigates capability behaviors two different tooth concentrated winding topologies traction electric machine applications well known conventional teeth poles winding also new teeth poles winding low magnetomotive force mmf harmonic contents investigated using winding types two permanent magnet machines designed analyzed performances compared considering main machine parameters electromagnetic torque losses field weakening capability thermal behavior also noise vibrations characteristics obtained results show significant advantages new machine conventional design new teeth poles machine design prototype machine built several measurements results electromagnetic torque machine efficiency given
aim mental health related stigma affects helpseeking behavior service utilization among young people whether mental health related stigma different correlated parents children unknown also unknown whether name change schizophrenia long term effects reducing stigma adults general population methods recruited parent child pairs mean ages years respectively complete self report questionnaires regarding mental health related stigma experience also assessed negative stereotypes three psychiatric disease names old new names schizophrenia depression diabetes mellitus physical illness comparison questionnaires also asked respondents identify old new names schizophrenia dementia respectively among names mental physical illnesses conditions results parents showed lower stigma levels toward mental illness diabetes mellitus similar greater stigma levels toward schizophrenia compared children stigma levels toward mental illness parents children significantly correlated rate correct identification old new names schizophrenia higher parents children parents responded correctly endorsed negative stereotypes toward new name schizophrenia compared responded incorrectly conclusion present findings suggest stigma toward mental illness shared family members name change schizophrenia effectively reduced stigma levels toward disorder adults various ages
engine downsizing use smaller engine provides power larger engine considered mega trend internal combustion engine market usually achieved using one boosting devices including supercharger turbocharger although supercharging beneficial engine transient response turbocharging technology widely adopted considering advantages fuel efficiency compared turbocharged compression ignition engines turbocharged spark ignition engines tend challenging respect gas exchange process mainly due higher pumping loss need throttling fact spark ignition engines demand controllability due mitigation knock particularly regard minimizing trapped residuals challenges encourage entire gas exchange process turbocharged spark ignition engines regarded complete air management system instead looking boosting system isolation addition research emphasis focused novel approaches improve gas exchange process downsized turbocharged spark ignition engines refinement conventional technologies provide continuous gains indefinitely innovative concept may improve engine performance meet fuel efficiency target stringent emission regulation future article first briefly review knowledge current state art technologies production opposed approaches currently investigated research level next novel methods gas exchange process introduced identify improved synergies engine boosting machine major findings improve gas exchange process emerge review comprise four aspects depending location novel technologies implemented follows charge air pressurization pressurization improvement combustion efficiency enhancement within chamber valve event associated development exhaust system optimization although interaction technologies different aspects gas exchange process found highly complex optimization combination technologies anticipated improve downsized turbocharged spark ignition engine performance
article investigate lump solutions kadomtsev petviashvili equation dimensions describe dynamics plasmas fluids via symbolic computation lump solutions dimensional kadomtsev petviashvili equation derived based bilinear forms conditions guarantee analyticity rational localisation lump solutions presented lump solutions contain eight parameters two totally free six need satisfy presented conditions plots particular choices involved parameters made show lump solutions energy distributions
problems result locally non differentiable hence non smooth state space equations often encountered engineering examples include problems involving material laws pertaining plasticity impact highly non linear phenomena estimating parameters systems poses challenge particularly since majority system identification algorithms formulated basis smooth systems assumption observability identifiability time invariance smooth system observable state remains observable throughout system evolution exception selected realizations state vector however non smooth system observable set states parameters may vary evolution system throughout dynamic analysis may cause standard identification methods extended kalman filter temporarily diverge ultimately fail accurately identifying parameters system work influence observability non smooth systems performance extended unscented kalman filters discussed novel algorithm particularly suited purpose termed discontinuous extended kalman filter dekf proposed elsevier ltd rights reserved
synthesis biotinylated conjugates synthetic analogues potent selective histone deacetylase hdac inhibitor largazole reported thiazole moiety parent compound cap group derivatized allow chemical conjugation biotin derivatized largazole analogues assayed across panel hdacs retained potent selective inhibitory activity towards class hdac isoforms biotinylated conjugate shown pull hdacs
paper presents approach high level modeling electromechanical systems proposed methodology starts low level description generate automatically corresponding bond graph model following steps consist finding behavioral model state space representation wich enriched information needed compute energy consumption losses system development done using systemc ams modeling environment particularly well suited language high level modeling heterogeneous systems modeling electromechanical filter used case study
state qatar experienced sandstorm night april lasting approximately hours winds average particulate matter approximately diameter emergency department main tertiary hospital qatar managed total emergency calls higher triage order peak load patients event manifested approximately hours onset major emergency command centre hospital ensured department maximally organized terms disaster management established protocols brought action multiple timely meetings convened efforts effectively execute plans included rapid emergency medical services handover time resourcing staff maximizing bed space preventing dust entry bypassing certain administrative processes canceling day surgeries affect inpatient morbidity procuring additional respiratory equipment patients arrived mainly exacerbations asthma respiratory distress ophthalmic emergencies vehicular trauma surprisingly incidence pedestrian injuries vary
backgroundwhile left atrial enlargement known early sign left heart disease prognostic implications heart failure importance right atrial enlargement less well studied prognostic implications interatrial size comparison insufficiently understood aim study test hypothesis area larger area apical four chamber view associated cause mortality elderly patients independent left ventricular ejection fraction lvef methodsretrospectively patients years hospitalized april april underwent echocardiogram enrolled cause mortality registered follow least months baseline parameters measured area area volume lvef left ventricular mass lvm tissue doppler systolic velocity right ventricular free wall smrv presence severe tricuspid regurgitation tricuspid gradient central venous pressure systolic pulmonary artery pressure well parameters diastolic function resultsin univariate analysis larger associated cause mortality hazard ratio relation larger cause mortality remained even adjusting age heart rate lvef atrial fibrillation percutaneous coronary intervention lvm index volume index smrv presence severe conclusionra larger independently lvef associated cause mortality elderly patients hospitalized due
previous studies reported patients idiopathic pulmonary fibrosis occasionally develop lung cancer however connective tissue disease ctd related interstitial lung disease ild data regarding development aim present study evaluate clinical significance development patients ctd ild retrospective review database patients ild identified patients diagnosed ctd ild overall cumulative incidences calculated addition risk factors prognostic impact development evaluated median age ild diagnosis years range years patients female median follow period ild diagnosis months range months period patients developed overall incidence cumulative incidences years respectively risk development significantly higher patients higher smoking pack year odds ratio confidence interval emphysema chest high resolution computed tomography median overall survival time developing months months common cause death ild according cox proportional hazard model analysis time dependent covariates patients developed showed significantly poorer prognosis hazard ratio ctd ild clinicians careful risk development patients heavy smoking history subsequent emphysema although frequent complication could poor prognostic determinant
biologic agents important therapeutic options treating multiple moderate severe cutaneous diseases monoclonal antibodies already use investigation targeted psoriasis atopic dermatitis melanoma hidradenitis suppurativa pemphigus vulgaris
problem solving one important mathematical capacities bases learning mathematical concepts procedures representations however students show difficulties problem solving multiplicity representations given mathematical concept object aim study determine relevance impact using visual representations transformations teaching process divisors multiple number impact problem solving notions follows qualitative methodology paper analyze educational intervention group students years old results show visual representations allowed transformations representations treatments conversions characteristics symbolic verbal representations visual representations provided learning environment multiple representations diversified transformation representations treatments conversions iii effect extended considered interval time three months conclude use visual representations enhances transformations representations contributed improvement students overall performance
paper present intelligent reliable storage efficient video surveillance system using apache storm opencv storm topology added multiple information extraction modules write important content disk topology extensible capable adding novel algorithms per use case without affecting existing ones since processing independent framework also highly scalable fault tolerant makes best option organisations need monitor large network surveillance cameras
vocalizations convey information individual motivational internal social status circumstances change individuals respond adjusting vocal behavior accordingly european starlings male acquires nest site socially dominates males dramatically increases courtship song although circulating testosterone associated social status vocal production possible steroid receptors fine tune status appropriate changes behavior explored possible role androgen receptors male starlings acquired nest sites produced high rates courtship song subset males occurred even absence elevated circulating testosterone immunolabeling androgen receptors arir highest medial preoptic nucleus pom males nest site elevated testosterone hvc arir higher dominant males high testosterone males sang longer songs dominant males low testosterone males sang shorter songs arir dorsal medial portion nucleus intercollicularis elevated males high testosterone irrespective dominance status song bout length related positively arir pom hvc testosterone concentrations related positively arir pom results suggest role testosterone vocal behavior differs across brain regions support hypothesis testosterone pom underlies motivation testosterone hvc relates song quality testosterone stimulates vocalizations data also suggest singing may influence independent testosterone alternative androgen independent pathways regulate status appropriate singing behavior elsevier inc rights reserved
efficient treatment hematological malignancies acute myeloid leukemia myelofibrosis chronic myeloid leukemia requires elimination cancer initiating cells prevention disease relapse targeting pathways stimulate generation maintenance cells mammals inhibition smoothened key mediator hedgehog signaling pathway reduces chronic myeloid leukemia progression propagation findings make smo candidate target inhibit maintenance leukemia initiating cells drosophila melanogaster pathway maintains hematopoietic precursor cells lymph gland hematopoietic organ develops larva using drosophila vivo model investigated mode action small molecule inhibitor human smo protein drosophila larvae fed showed traits altered hematopoietic homeostasis include development melanotic nodules increase circulating hemocytes size increase lymph gland accelerated differentiation blood cells likely due exit multi potent precursors quiescence importantly smo inhibition lead complete loss hematopoietic precursors conclude inhibits drosophila smo blocking signaling pathway causing loss hematopoietic precursor cells interestingly effect expected patients treated number decrease cancer initiating cells bone marrow reduce risk leukemia relapse altogether results indicate drosophila comprises model system vivo study molecules target evolutionary conserved pathways implicated human hematological malignancies
study aimed evaluate factor structure conflict resolution styles inventory crsi southern brazilian population also aimed relate four dimensions conflict resolution positive problem solving conflict engagement withdrawal compliance scale sociodemographic variables order understand couples handle conflicts participants study married women married men mean age years living current partner average years participants answered sociodemographic questionnaire crsi data revealed componential structure similar original scale positive problem solving style used men women even though data evidenced pattern demand women withdrawal men adaptations recommended use portuguese version scale
paper introduced necessity constructing green ecological architecture system wuhan city circle combined characteristics development green building city construction regional green ring hierarchical planning promotion green building materials application renewable energy establishment green building evaluation system several aspects analysis put forward measures constructing green ecological system discusses supervision management mechanism green building summary outlook future wuhan green building development direction
hamstring injuries research physical education teacher education pete students far within frame development injury prevention program study conducted analysis modifiable risk factors hamstring injuries pete students hamstring injuries freshmen bachelor pete students registered prospectively one academic year eighty one students completed maximum muscle strength tests hip extensors hamstrings quadriceps isometric hamstrings eccentric start academic year sixty nine latter completed single leg hop distance slhd risk factors hamstring injuries statistically detected using logistic regression sixteen hamstring injuries injuries student academic year injuries occurred participants eight cases included risk factor analysis lower eccentric hamstring strength odds ratio odd higher isometric eccentric hamstring strength ratio odd lower score slhd odd significant risk factors hamstring injury combination eccentric hamstring strength test slhd could give good risk analysis hamstring injuries pete students might offer great perspectives easily applicable screening clinical setting
free viewpoint video fvv offers compelling interactive experience allowing users switch viewing angle time fvv composed large number camera captured anchor views virtual views captured camera rendered nearby anchors using techniques depth image based rendering dibr consider group wireless users may interact fvv independently switching views study novel live fvv streaming network user pulls subset anchors server via primary channel enhance anchor availability user user generates network coded packets using anchors broadcasts direct neighbors via secondary channel given limited primary secondary channel bandwidths devices seek maximize received video quality minimize distortion jointly optimizing set anchors device pulls anchor combination generate packets best knowledge among first body work addressing joint optimization problem wireless live fvv streaming based collaboration first formulate problem show hard propose scalable effective algorithm called pafv peer assisted freeview video pafv node collaboratively distributedly decides anchors pull packets share minimize video distortion neighborhood extensive simulation studies show pafv outperforms algorithms achieving substantially lower video distortion often significantly less redundancy much android based video experiment confirms effectiveness pafv comparison schemes
loss extracellular superoxide dismutase sod contributes inflammatory fibrotic lung diseases human sod polymorphism decreases matrix binding redistributing sod lung extracellular fluids protects lps induced alveolar inflammation used mice expressing naturally occurring single nucleotide polymorphism within heparin binding domain sod results amino acid substitution position test hypothesis redistribution sod extracellular fluids would impart protection bleomycin induced lung fibrosis secondary pulmonary hypertension mice sod content activity increased extracellular fluids decreased lung baseline greater increases bronchoalveolar lavage fluid balf sod compared wild type mice days bleomycin mice developed less fibrosis based pulmonary mechanics fibrosis scoring collagen quantification gene expression days less right ventricular systolic pressure pulmonary arteriole medial wall thickening days wild type mice macrophages lymphocytes neutrophils proinflammatory cytokines protein increased balf day mice total balf cell counts increased day resolved days days balf pro antiinflammatory cytokines balf protein higher mice resolving days conclude redistribution sod result single nucleotide polymorphism protects mice bleomycin induced fibrosis secondary improved resolution alveolar inflammation
technological education different kind education since manages channel students beyond conventional frontal learning paper refers educational process secondary education grade technological education courses electric circuit house important piece utility network authors create original educational software made two main components one informative part directly taught whole class didactic movie refers knowledge abilities accumulated students module energy second one interactive part used apply information individual collective activities verified measured interactive part allows students make draft regarding electrical circuits plugs light using specific symbols given plan house unlike academic learning process allows teacher see students different ways working individual pairs groups role teacher provide feedback comments reinforcement ict products creates new approach places student center allowing undergo process developing independent thinking finding personal solutions
photoplethysmography used wide range medical devices measuring oxygen saturation cardiac output assessing autonomic function detecting peripheral vascular disease artifacts render photoplethysmogram ppg useless thus algorithms capable identifying artifacts critically important however published ppg algorithms limited algorithm study design therefore authors developed novel embedded algorithm real time pulse waveform pwf segmentation artifact detection based contour analysis time domain paper provides overview pwf artifact classifications presents developed pwf analysis demonstrates implementation bit arm core microcontroller pwf analysis validated data records subjects acquired sleep laboratory ergometry laboratory intensive care unit equal parts output algorithm compared harmonized experts annotations ppg total duration algorithm achieved beat beat comparison sensitivity specificity precision accuracy interrater agreement expressed cohen kappa coefficient measure conclusion pwf analysis seems suitable method ppg signal quality determination real time annotation data compression calculation additional pulse wave metrics amplitude duration rise time
introduction thewidespread introduction integrase inhibitors clinical practice transmission drug resistance class antiretroviralmedications may expand aimof studywas analyze recent patterns resistance treatment naive individuals northern poland association transmitted protease reverse transcriptase mutations methods study included ini sequences antiretroviral treatment naive hiv infected patients linked care northern poland drug resistance interpreted based surveillance ias usa mutation lists phylogeny maximum likelihood bayesian monte carlo markov chain analyses used results overall rate transmitted drug resistancewas nucleoside reverse transcriptase inhibitor nrti resistance associated substitutionswere found cases non nucleoside reverse transcriptase inhibitor resistance variants multivariate models transmitted resistance strongly associated subtype infections compared subtype transmission major protease integrasemutationswere observed polymorphisms associatedwith resistance integrase inhibitor mostly found sequences associated female male injection drug use compared heterosexual men sex men transmissions well hepatitis coinfection positive versus hcv antibody negative clusters nucleoside reverse transcriptase mutations subtype integrase variants subtype observed conclusions transmitted drug resistance frequency high subtype limited clustered nrti mutations infrequent among subtype infected cases despite lack major integrase resistance treatment naive patients variants potentially affecting susceptibility classwere common indicates potential need extended surveillance near future elsevier rights reserved
social learning requires inferring social information another person well evaluating outcomes previous research shows prior social information biases decision making reduces reliance striatal activity learning delgado frank phelps nature neuroscience rich literature social psychology person perception demonstrates people spontaneously infer social information viewing another person fiske taylor engage network brain regions including medial prefrontal cortex temporal parietal junction superior temporal sulcus precuneus amodio frith nature reviews neuroscience haxby gobbini montgomery van overwalle human brain mapping investigate role brain regions social learning well established dimensions person perception trait warmth trait competence test hypothesis activity person perception brain regions interacts learning structures social learning participants play investment game must choose agent invest behalf choice guided cues signaling trait warmth trait competence based framing monetary returns trait warmth information impairs learning human computer agents trait competence information produces similar learning rates human computer agents see increased activation warmth information human agents person perception brain regions interestingly activity person perception brain regions decision phase negatively predicts activity striatum feedback trait competence inferences humans results suggest social learning may engage additional processing within person perception brain regions hampers learning economic contexts
study energy exergy environmental enviroeconomic exergoenvironmental exen exergoenviroeconomic exenec analyses performed solar collector enviroeconomic energy based environmental analysis exen exergy based environmental analysis exenec exergy based environmental economic analysis analyses firstly conducted kind system literature found energy exergy lost radiation major reason big temperature difference sky glass surface collector furthermore energy efficiency system higher corresponding exergy efficiency also solar exergy system maximum exergy input rate destructed system due irreversibility shows major disadvantages solar collector system exen result day lower corresponding environmental one day enviroeconomic result day higher exenec result day exergy based exenec method reliable generally concluded solar collector systems assessed effectively using exergy economy based exen exenec methods respectively due consideration environmental condition useful energy calculation
fuzzy systems used widely thanks ability successfully solve wide range problems different application fields however replication application require high level knowledge experience furthermore researchers publish software source code associated proposals major obstacle scientific progress disciplines industry recent years fuzzy system software developed order facilitate use fuzzy systems software commercially distributed software available free open source software reducing obstacles providing many advantages quicker detection errors innovative applications faster adoption fuzzy systems etc paper present overview freely available open source fuzzy systems software order provide well established framework helps researchers find existing proposals easily develop well founded future work accomplish propose two level taxonomy describe main contributions related field moreover provide snapshot status publications field according isi web knowledge finally considerations regarding recent trends potential research directions presented
discretization method proposed rather general class nonlinear continuous time systems piecewise constant input one digital control via zero order hold device resulting discrete time model expressed product integration gain system function governs dynamics original continuous time system made possible use delta euler operator makes comparisons discrete continuous time systems quite simple since difference two forms concentrated integration gain gain determined paper using riccati approximation certain gain condition imposed discretized system exact model method shown produce smaller error norm one uses linear approximation simulations carried lotka volterra averaged van der pol nonlinear systems show superior performance proposed model ones known online computable forward difference kahan mickens methods insights obtained useful developing digital control laws nonlinear continuous time systems currently limited simplest forward difference model
superior maneuverability insect flight enabled rapid significant changes aerodynamic forces result subtle precise change wing kinematics high sensitivity aerodynamic force wing kinematic change demands precise instantaneous feedback control wing motion trajectory especially presence various parameter uncertainties environmental disturbances current work flapping wing robots limited open loop averaged wing kinematics control present instantaneous closed loop wing trajectory tracking motor direct driven wing thorax system resonant flapping dynamic model parameter uncertainties disturbances developed validated system identification wing trajectory generation designed hopf oscillator based central pattern generator smooth convergence using linearized model treating nonlinearity disturbance designed proportional integral derivative pid controller linear quadratic regulator lqr instantaneous wing trajectory tracking using original nonlinear model designed nonlinear controller achieve robust performance control algorithms implemented compared experimentally flapping wing micro air vehicle mav experiments showed pid nonlinear controls resulted precise trajectory tracking lqr controller tracked less precision smaller input effort addition nonlinear control algorithm achieved better tracking wing trajectories varying amplitude bias frequency split cycles adapting variations wing morphological parameters wing geometry stiffness furthermore lift force measurements nonlinear control results compared open loop average wing kinematics control commonly adopted current designs
retrospective review intra articular calcaneal fractures treated open reduction internal fixation specialist team supervision single surgeon tertiary centre fractures evaluated plain radiography computed tomography graded using eastwood atkins classification lateral approach used fractures fixed calcaneal plates patients clinical radiological follow clinical assessment included foot ankle disability index kerratkins scores mean follow duration months range months mean age patients years range years three open fractures eight patients injuries mean bohler angle improved degrees preoperatively degrees postoperatively mean foot ankle disability index score mean scores physical component mental component mean kerr atkins score range early complications included one case screw protrusion subtalar joint warranted repeat procedure one sural nerve injury one wound breakdown healed non operative measures twelve patients symptomatic subtalar joint osteoarthritis four subtalar fusion believe strict protocols patient selection intraoperative postoperative management produced long term results comparable peer reviewed literature
objective explore clinical allergologic characteristics pediatric asthma lambarene gabon patients methods descriptive cohort study consisted children wheezing respiratory disease included consecutively january july clinical evaluation skin tests functional capacity measurements environmental characterization achieved results seventy three patients aged years included diagnosis asthma retained children rhinitis eczema symptom frequent clinical scores showed severe persistent asthma moderate asthma mild persistent asthma intermittent asthma presence domestic animals smokers uncommon asthmatics sporadically received prolonged treatment inhaled corticosteroids functional tests showed severe obstructive syndromes including reversible moderate obstructive syndromes including reversible sixty one percent tested patients positive prick test least one allergen percentage asthmatic patients sensitized dust mites cockroaches dog grasses peanuts alternaria house dust samples revealed small amounts dermatophagoides conclusion asthma medical condition affecting pediatric population semi rural areas gabon number severe asthma however low two thirds cases sensitization allergens home environment observed lead better overall care including optimization allergen avoidance drug therapy development therapeutic patient education elsevier masson sas rights reserved
investigate types childhood maltreatment abuser abused relational ties best predict dissociative disorder psychiatric inpatients mean age completed measures dissociation trauma abuse type abuser abused relational ties recorded traumatic experiences questionnaire multidisciplinary team clinical diagnosis administration scid high dissociators confirmed diagnoses logit models described relationships abuser abused relational tie diagnostic grouping patients present absent fisher exact tests measured relative contribution specific abuse types positive relationship abuse frequency presence patients experienced abuse patients without dds two combinations abuse type relational tie predicted childhood emotional neglect biological parents siblings later emotional abuse intimate partners findings support early childhood etiology dds subsequent maladaptive cycles adult abuse enquiries childhood maltreatment include history emotional neglect biological parents siblings adult emotional abuse intimate partners assist screening dds
background impact health related quality life hrql well studied children immunoglobulin ige mediated food allergy however limited data exists related quality life qol families child suffering food protein induced non ige mediated gastrointestinal allergies aimed establish qol families children beginning following elimination diet non ige mediated gastrointestinal food allergies methods prospective observational study performed parents children aged weeks years improved weeks following elimination diet suspected non ige mediated allergies included family impact module fim pediatric quality life pedsql used compared data two historical cohorts one sickle cell disease another intestinal failure results one hundred twenty three children median age months included boys total fim score particularly low daily activities worry factors impacted significantly included age number foods excluded symptom severity chronic nasal congestion children non ige mediated food allergies worse scores domains compared sickle cell disease worse physical emotional worry domains compared intestinal failure conclusions study found parent qol family functioning worse families child elimination diet non ige mediated allergies compared sickle cell disease intestinal failure highlighting impact disease families
background patients psychiatric disorders high rate suicide present study investigated factors influencing hospital stays japanese patients psychiatric disorders attempting suicide jumping methods diagnosed suicide attempts jumping based international classification diseases revision icd investigated mean hospital stays patients diagnosis based icd code analyzed differences demographic clinical characteristics diagnostic groups identify factors influencing duration hospital stay results patients diagnosed schizophrenia code frequent diagnoses therefore divided diagnostic groups schizophrenia group psychiatric diagnoses group patients schizophrenia showed significantly longer hospital stay days compared patients psychiatric diagnoses beta whereas difference jump height two groups average floor number injured parts particularly lower limb fractures significantly higher patients schizophrenia patients psychiatric diagnoses duration psychiatric treatment patients schizophrenia significantly longer patients psychiatric diagnoses conclusion findings indicate number injuries body parts injured patients schizophrenia associated longer duration hospital stay following suicide attempt jumping current use antipsychotics longer duration taking antipsychotics might contribute risk bone fracture via hyperprolactinemia cognitive impairment patients schizophrenia might prevent rehabilitation management lower limb fractures results suggest clinicians monitor level prolactin cognitive function patients schizophrenia future studies managing lower limb fractures
paper constant voltage power generation system based novel memory machine proposed implemented memory machine offer direct efficient air gap flux control due creative integration memory concept doubly salient machine structure utilizing memory machine direct drive wind power generation resulting system realize constant voltage operation different load conditions addressing memory machine design characteristics analysis using finite element method paper presents detailed implementation control principle constant voltage power generation system numerical simulation prototyping test conducted verify validity proposed machine system elsevier ltd rights reserved
superconducting fault current limiters sfcls themost attractive devices power network limiters used limit short current electrical network paper presents design numerical model calculated electrical parameters new class sfcl prototype coreless superconducting fault current limiter consists three windings primary secondary windings made tape parallel connected primary copper winding windings inductively coupled intended work liquid nitrogen transient magnetic fem circuit numerical models sfcl used analyze current resistance temperature sfcl limitation state
aim study identify novel tnf alpha blocking peptide using phage display technology two novel mer tnf alpha binding peptides values identified phage particles displaying peptides concentration prevent cytotoxic effect tnf alpha cells respectively synthesized peptides also inhibited tnf alpha induced cytotoxicity values respectively result pcr also supports inhibitory activity identified peptides significantly inhibit inductive effect tnf alpha kappa alpha mrna levels inhibitory effects peptides attributed abilities binding intersubunit interfaces leading tnf alpha dissociation results molecular docking studies revealed peptides tnf alpha complexes mostly stabilized hydrophobic contacts elsevier rights reserved
paper deals susceptibility analog integrated circuits radio frequency interferences rfi concentrates effects induced rfi operation offset compensated chopped cmos operational amplifiers first part work explains causes additional output offset induced input disturbances chopped systems afterwards design chopped cmos operational transconductance amplifier ota briefly treated final part paper results simulations performed ota presented order highlight concepts discussed first second paragraphs
objectives study influence aortic root distensibility haemodynamic parameters valve kinematics bioprosthetic aortic valve investigated controlled vitro experiment methods edwards intuity elite sutureless aortic valve edwards lifesciences irvine usa inserted three transparent aortic root phantoms different wall thicknesses mimicking different physiological distensibilities haemodynamic measurements performed vitro flow loop heart rates bpm corresponding cardiac outputs min aortic pressures mmhg respectively aortic valve kinematics assessed using high speed camera geometric orifice area goa measured counting pixels lumen open aortic valve effective orifice area eoa calculated root mean square value systolic aortic valve flow rate mean systolic trans valvular pressure gradient results tested aortic root phantoms reproduce physiological distensibilities healthy individuals age groups ranging years years haemodynamic results show minor differences aortic root phantoms trans valvular pressure gradient tends increase stiffer aortic roots whereas systolic aortic valve flow rate remains constant consequence eoa decreased slightly less distensible aortic roots goa aortic valve opening closing velocities increase significantly reduced distensibility haemodynamic measurements resulting mean systolic flow velocity aortic valve orifice lower stiffer aortic root conclusions aortic root distensibility may influence goa aortic valve kinematics affects mechanical load aortic valve cusps whether changes significant effect onset structural valve deterioration bioprosthetic heart valves needs investigated
article explores ways london lives written together romantic period considering representations across different genres media including poetry william wordsworth richard horwood house house plan city fores new guide foreigners volume harris list covent garden ladies richard phillips modern london pierce egan life london pays particular attention recovering evidence marginalised individuals whose lives never written book article length traces survive glimpses aggregated forms plate series directories also discusses life writing communities representation common knowledge use statistics contrasting confident assertions knowledge made guides mapping topography conflicted fragmented modes common poetry novels examining issues contends considerable benefits thinking life writing intrinsic far wider range discourses standard biographical autobiographical modes arguing broader conception invaluable recovering occluded existences modelling collective experience understanding hierarchies implicit ways lives culturally inscribed
current study tested hypothesis substance abuse features internalizing externalizing disorder confirmatory factor analysis cfa data adjudicated delinquents supported three factor model negative emotionality fearlessness disinhibition alternate one two internalizing externalizing factor models second cfa indicated self reported offending substance abuse formed separate dimensions rather single dimension correlating several temperament personality indicators measures substance misuse offending revealed substance misuse significantly aligned internalizing dimension negative emotionality significantly less aligned fearlessness externalizing dimension
recent papers highlight presence large numbers compressed angles metal ion coordination geometries metalloprotein entries worldwide protein data bank due mainly multidentate coordination prevalence compressed angles raised controversial idea significantly populated aberrant even novel coordination geometries may exist papers undergone severe criticism apparently due views held canonical coordination geometries exist significant numbers criticism controversial ideas warranted expected believe line crossed unfair criticism put forth discredit inconvenient result compressed angles exist large numbers support dogmatic canonical coordination geometry view present review major controversial results criticisms pointing good suggestions incorporated new analyses also unfair criticism put forth support particular view also suggest better science enabled collegial collaborative approach future critical reviews requirement description methods data including source code visualizations enables full reproducibility results proteins wiley periodicals inc
paper corrected parallel smoothed particle hydrodynamics sph method proposed simulate generalized newtonian free surface flows low reynolds number especially viscous jets buckling problems investigated proposed sph method achieved coupling improved sph method based incompressible condition traditional sph tsph improved sph diffusive term first order kernel gradient correction scheme used interior fluid domain tsph used near free surface thus sph method possesses advantages two methods meanwhile effective convenient boundary treatment presented deal multiple boundary problem mpi parallelization technique dynamic cells neighbor particle searching method considered improve computational efficiency validity merits sph first verified solving several benchmarks compared results viscous jet folding coiling based cross model simulated sph method compared experimental numerical results specially influences macroscopic parameters flow discussed numerical results agree well available data show sph method higher accuracy better stability solving moving free surface flows particle methods elsevier rights reserved
hydrological models remote sensing evapotranspiration models usually used estimate regional study aims integrate advantages models simulate daily processes compromise two methodologies represented improving optimization hydrological model basis new probability optimal series produced data assimilation scheme combining sparse remote estimates continuous modeling regional ets distributed time variant gain hydrological model dtvgm two layer remote sensing model chosen first dtvgm optimized maximizing nash sutcliffe efficiency daily streamflow shahe river basin simulates daily hydrological processes improving accuracy continuous simulation dtvgm optimized dual objective functions composed assimilated ets observed outlet discharge results show accuracy dtvgm based daily ets improved dual optimization mean absolute percentage error dtvgm based ets measured ets study area reduced integrated method proved better improves hydrology modeling accuracy
multiple sclerosis inflammatory neurodegenerative disease central nervous system primary symptoms include loss sensory motor function exercise shown modulate disease parameters experimental autoimmune encephalomyelitis eae mouse model reducing immune cell infiltration oxidative stress however initial studies carried exclusively female mice present study compared effects daily voluntary wheel running several disease parameters male female mice eae male female mice given access running wheel day consecutive days daily wheel running significantly improved clinical scores males eae little effect clinical signs females disease direct comparison inflammation axonal injury oxidative stress male female mice eae revealed significant differences amount cell infiltration microglia reactivity demyelination axon integrity male mice eae given daily access running wheels also significantly less ongoing oxidative stress compared groups taken together results indicate inflammatory response generated eae distinct sexes modulation daily exercise sex specific effects disease related outcomes elsevier rights reserved
need operational monitoring landscape processes national global scale led increased demand pixel based composites using complete earth observation archives commonly composites generated without explicit consideration temporal criteria rather based optimizing band indices within pre defined temporal window however certain applications phenology adapted composites represent land surface phenological stage required tree type discrimination greening senescence dates modified terrain elevation developed novel pixel based compositing technique dynamically adjusts selection process underlying land surface phenology lsp pixel phenologically sound composites across large areas derived regular intervals different phenological points time peak end minimum season various day year doy scoring functions implemented flexibly define phenological target technique general enough global application applied kind gridded archive herein demonstrated modis landsat data multi annual composites successfully generated zambia seasons exception found even frequent modis observations insufficient peak vegetation composites due interference rainy season phenology adaptive composites compared static ones using single target doy results clearly indicated biomass levels differ significantly techniques phenological normalization across elevation gradients land cover classes could achieved however implications non trivial characteristics methods need considered cautiously deciding approach superior regards specific thematic application quality modis landsat composites well performance phenology adaptive static compositing techniques assured using quantitative cross comparison year annual time series demonstrated feasibility land cover change modification mapping several change processes clearly discriminable resulting phenologically coherent composites important establish national regional even global landscape monitoring reporting verification systems elsevier inc rights reserved
paper investigates concern green buildings may promote energy efficiency aspects sustainability necessarily health well occupants better indoor air quality iaq ask ten questions explore iaq challenges green buildings well opportunities improve iaq within green buildings programs focus iaq recognizing many factors influence human health healthfulness building begin overview green buildings iaq whether green building certifications address iaq next examine evidence whether green buildings better iaq comparable conventional buildings identify called green practices green products unintended unfavorable effects iaq looking ahead offer immediate longer term actions set research questions help green buildings effectively promote iaq article supports growing recognition importance iaq green buildings opportunities improvements world green building council others emphasized people valuable asset organizations efforts improve iaq improve health well productivity profitability authors published elsevier ltd
immediately recalling witnessed event increase people susceptibility later postevent misinformation retrieval enhanced suggestibility res effect shown initial recall test included specific questions reappeared final test moreover unclear whether phenomenon affected centrality event details limitations make difficult generalize res criminal investigations often begin free recall prior specific queries legal officials attorneys experiments examined influence test formats free recall cued recall centrality event details central peripheral res experiment initial final tests cued recall experiment initial test free recall final test cued recall experiment initial final tests free recall initial testing increased misinformation reporting final test peripheral details experiments effect significant central details aggregating data experiments results show initial free recall produce res broadly free recall potentiate subsequent learning complex prose materials
study question pharmacodynamic interaction ulipristal acetate upa emergency contraception daily progestin contraceptive pill desogestrel dsg initiated next day summary answer study dsg impaired ability upa delay ovulation upa little impact onset contraceptive effects due dsg known already upa progesterone receptor modulator used emergency contraceptive dose upa delays ovulation least days administered mid late follicular phase theory potent progestins could reactivate progesterone signaling leads follicle rupture thereby impacting effectiveness upa addition upa could alter onset contraceptive effect progestin containing contraceptives started immediately upa study design size duration single blind observer placebo controlled partial crossover study conducted two sites dominican republic netherlands ndl months october september healthy female volunteers participated two three treatment cycles separated washout cycle treatment combinations studied follows single dose upa followed per day dsg days single dose upa followed days placebo matching dsg plb iii one tablet placebo matching upa plb followed per day dsg days participants randomized one three treatment sequences upa dsg upa plb plb dsg upa dsg upa plb plb dsg lead follicle diameter transvaginal ultrasound imaging tvu participants material setting methods total women included randomized first treatment combination three period sequences ndl continued completed two treatment combinations ndl main results role chance initiating dsg treatment day upa significantly reduced ovulation delaying effect upa ovulation occurred one upa cycles first days occurred upa dsg cycles limitations reasons caution small descriptive pharmacodynamic study findings differed study site distinguishing cystic corpus luteum luteinized unruptured follicle luf tvu difficult cases however investigators reached consensus study still blinded regarding ovulation based hormone levels careful review daily tvu images wider implications findings initiating use dsg progestin pill pop immediately upa reduces ability upa delay ovulation thus may decrease efficacy starting dsg pop using upa possibly progestin method consideration given delaying least days upa intake order preserve ovulation delaying effects upa
earlier association rule data mining mainly used analysis market basket data scope widened experimented various areas extraction interesting correlations help like healthcare education systems manufacturing engineering network management intelligence etc android new technology came use researchers touched area applying association rule mining android applications implementation association rule growth algorithm similar android applications clones done novel area paper describes framework mines association rules android application clones analysis rules dependencies proved fruitful gave useful results interesting relations extracted codes help developers performing future operations like modification code easily
background human brain complex system known universe therefore one greatest mysteries provides human beings extraordinary abilities however understood yet abilities produced aims decades researchers trying make computers reproduce abilities focusing understanding nervous system processing data efficient way aim make computers process information similarly brain important technological developments vast multidisciplinary projects allowed creating first simulation number neurons similar human brain conclusion paper presents date review main research projects trying simulate emulate human brain employ different types computational models using parallel computing digital models analog models hybrid models review includes current applications works well future trends focused various works look advanced progress neuroscience still others seek new discoveries computer science neuromorphic hardware machine learning techniques outstanding characteristics summarized latest advances future plans presented addition review points importance considering neurons computational models brain also include glial cells given proven importance astrocytes information processing
although consensus view agreeableness originates childhood difficultness regulatory deficits studies investigated assumptions longitudinally study examined issue assessing enduring mediating effects self regulation well impact parenting behaviors development agreeableness preschool late adolescence longitudinal data norwegian families following children years years used path analyses revealed childhood difficultness age related agreeableness age effect mediated emotion regulation late childhood however mediation effects primarily found parents used punitive practices towards children findings point personality coherence throughout development elsevier inc rights reserved
cross sectional study aimed investigate relationship caregivers care receivers defined home dwelling family members dementia used self rating questionnaire felt expressed emotion rating scale feers simple questions measure caregiver perceptions care receiver criticisms ccs emotional overinvolvement eoi toward caregiver performed factor analyses rank single items feers pertaining eoi included caregiver care receiver pairs logistic regression analyses tested associations feers items caregiver care receiver variables main contributors caregiver perceptions caregiver distress amount time spent care receiver socially distressed caregivers perceived care receiver emotionally overinvolved offering psychosocial intervention tailored program target caregiver perceived relationship family member caregiver distress program also endeavor give caretaker opportunities leisure time
high level abstractions separate algorithm design platform implementation allowing programmers focus algorithms building complex systems separation also provides system programmers compilers opportunity optimize platform services application application basis fieldprogrammable gate arrays fpgas platform level malleability extends memory system unlike general purpose processors memory hardware fixed design time capacity associativity topology fpga memory systems may tuned improve application performance since application kernels may explicitly use memory resources substantial memory capacity may available platform use behalf user program work present scavenger utilizes spare resources construct program optimized memories also perform initial exploration methods automating construction application specific memory hierarchies although exploiting spare resources beneficial naiively consuming memory resources may cause frequency degradation relieve timing pressure large block ram bram structures provide microarchitectural techniques trade memory latency design frequency demonstrate examining set benchmarks scalable cache microarchitecture achieves performance gains geometric mean average baseline cache microarchitecture scaling size first level caches maximum
electric vehicles ultimate eco friendly vehicles tailpipe emission automotive industry turned electrically powered vehicle owing problems caused gasoline engine people well environment paper explains electric vehicle works compares electric vehicle internal combustion engine hybrid vehicle also proposes optimum way use power recovered regenerative braking charging battery
motion address resolution protocol arp done without problem general environment considered security aspect therefore risks threatened attack network called arp spoofing arp poisoning attacker approach transmission data hosts disguising different host arp spoofing attack isolate host target attack network paper propose routing trace based network security system preventing arp spoofing attacks proposed system includes detection protection recovery techniques prevent arp spoofing attack internal network whether arp spoofing attack occurs confirmed periodic monitoring arp table routing trace system prevent arp spoofing attacks without modifications arp addition cryptographic measures addition provides security efficiency overcoming weak points existing researches
paper develop framework collecting enf electric network frequency variations database used digital media authentication time stamping proposed framework allows recording enf variations hum signal discontinuities introduced hum signal probe used data acquisition studied methods minimizing discontinuities proposed end method time stamping audio recordings used based created enf database
researchers field teaching learning higher education identified concerns top leadership models distributed shared leadership approaches may provide successful engagement institutional change agendas provide options reward recognise staff leading teaching learning initiatives empirical research jones colleagues conceptualised key criteria dimensions values constitute effective distributed leadership action self enabling reflective tool asert together benchmarks action taken enable distributed leadership evaluated opportunities distributed leadership incorporated design australian university professional recognition scheme university educators analysis case study context asert attributes benchmarks distributed leadership paper explores potential systematic professional recognition university educators build institutional leadership capacity context university teaching learning
aimsrefractory overactive bladder oab treatments including sacral neuromodulation snm onabotulinumtoxin onabota percutaneous tibial nerve stimulation ptns differ considerably best worst scaling bws used assess patient preferences treatments methodsa cross sectional web survey based findings qualitative interviews oab patients clinical experts conducted idiopathic oab patients bws exercise involved prioritizing subsets attributes across choice tasks patients identified attribute considered best worst task attribute bws scores ranging worst best calculated based rates attribute chosen attitudes toward attributes also assessed via like dislike likert scales questions regarding percentage likelihood trying treatment based standardized treatment descriptions resultsthe sample included patients female mean age years attribute bws scores significantly positive negative lasting improvement minimal side effects sends signals bladder brain rated favorably complications implant willing self catheterize rated worst one attribute bws scores significantly correlated respective like dislike scores percentage likelihood estimates trying one three treatments conclusionbws successful assessing magnitude patient preferences key attributes associated substantially different refractory oab therapies neurourol urodynam wiley periodicals inc
paper presents design capacitive wireless power transfer systems based class inverter approach main reason adopting class inverter approach high efficiency theoretically however operation class inverter highly sensitive circuit parameters typical capacitive wireless power transfer application capacitive coupling distance plates subject changes hence power transfer efficiency greatly affected class inverter properly tuned drawback motivates develop auto frequency tuning algorithm class inverter maintains power transfer efficiency spite variations capacitive coupling distances plates circuit parameters finally simulation experiment carried verify effectiveness auto frequency tuning algorithm
paper proposes simple method add optional live streaming highly interactive class way reduces number students physically present classroom hurt student performance effect allowing live streaming analyzed running experiment partway semester students flipped advanced level computer graphics class given option attend class remotely using live stream class required use multi featured audience response system teachback results show allowing remote attendance teachback decreased number students attending physically registered students effect unexcused absences students believed remote attendance effective learning attending classes face face analysis data confirmed beliefs however generally prefer physically present class results suggest appropriate use live streaming coupled audience response system reduce demand large lecture halls allowing self selected subset students attend classes remotely large percentage students class felt live streaming option added classes paper demonstrates goal feasible pedagogically justifiable
backgroundpolycystic ovary syndrome pcos common endocrine disease reproductive age women present study aimed determine effects dietary approaches stop hypertension dash diet reproductive hormones plasma total antioxidant status anthropometric indices overweight obese pcos women methodsin randomised controlled clinical trial women pcos randomly assigned one two diets energy restriction dash diet control diet dash control diets consisted carbohydrate protein total fat dash diet designed rich vegetables fruits whole grains low fat dairy products well low saturated fats cholesterol refined grains sweets present study anthropometric indices body composition total testosterone androstenedione sex hormone binding globulin shbg free androgen index diphenyl picryylhydrazyl dpph scavenging activity measured months resultsthe consumption dash diet compared control diet associated significant reduction weight versus body mass index bmi versus fat mass versus serum androstenedione versus value increased concentrations shbg versus nmol dpph scavenging activity versus also found dash group conclusionsthe dash diet could improve weight loss bmi fat mass furthermore could result significant reduction serum androstenedione significant increase antioxidant status shbg
overview identification continuous time models step responses using integral equation approach presented open loop closed loop identification well identification multiple input multiple output mimo models considered solutions practical implementation problems provided methods identification transient initial conditions using raw data well estimation algorithms presence disturbances outlined methodologies presented simplified way using example first order model however algorithms applicable models higher orders solution techniques estimation equations also discussed identification results different experimental conditions data quality presented demonstrate performance algorithms number experimental simulation examples presented demonstrate applicability approach
article presents core expansion method automatically detect border zone corridors mri images left ventricle serve guidance ventricular tachycardia ablation method relies fact different gray level intensities delayed contrast enhanced magnetic resonance images demri encode information fibrotic tissue differences intensities among tissue types allow separating dense scar healthy areas myocardium identify border zone region generating onion like layer based model left ventricle method detects potential corridors border zone become electrical circuits low conductivity circuits responsible arrhythmic events method tested phantoms patients patients high degree correlation channels detected visually identified expert mri whenever electroanatomical maps available post intervention mri detected channels found high degree correlation
well known strength materials influenced specimen structure size particular several experimental campaigns shown decrease material strength static fatigue loading increasing structure size theoretical arguments proposed interpret phenomenon far fatigue crack growth concerned limited information size effect available literature particularly called quasi brittle materials like concrete present paper exploiting concepts fractal geometry definitions fracture energy stress intensity factor based physical dimensions different classical ones discussed multifractal size dependent fatigue crack growth law expressing crack growth rate stress intensity factor range proposed used interpret relevant experimental data related concrete elsevier ltd rights reserved
background aims partner burden common celiac disease unclear parents children increased burden may translate depression anxiety meriting healthcare methods nationwide population based study parents spouses caregivers celiac patients caregivers matched controls caregivers identified swedish total population register linked data psychiatric disease national patient registry hazard ratios hrs depression anxiety reference outcome measure bipolar disorder examined lifetime fashion also temporal relationship date diagnosis using cox regression priori focused parents individuals diagnosed years age children age disease onset spouses individuals diagnosed adulthood parents spouses high risk caregivers likely live together patient time disease onset results cox analysis depression common high risk caregivers control caregivers anxiety common combining anxiety depression composite outcome measure statistically significant risk increase highest excess risks depression anxiety seen years diagnosis contrast bipolar disorder common caregivers patients conclusion caregivers patients may increased risk severe burden editrice gastroenterologica italiana published elsevier ltd rights reserved
aim paper discuss electrical machines building computation taking account change reluctance network topology required optimization process indeed electrical machine changes electrical period model consider several rotor positions analyze harmonic influence machine performance torque losses requirement also important applications machine geometry changes shortly sizing process optimization two cases addressed paper using established independent meshes initial paper proposes algorithm deal topologies necessary optimization process aims reduce computation time increase model improve solving stability output selectivity approach also applied modeling improve computation time optimization process simulation results compared finite element methods optimization performance presented
digitally controlled oscillators main cores digital phase locked loops adpll important determining range frequency power consumption adplls conventional digitally controlled oscillator dco designs one single band operation assigned dco following paper presents new approach design dcos works dual band wide band modes control unit dual band mode dco works two different ranges frequencies simultaneously via digital control bits wide band dco wbdco works one wider range frequencies consecutively seems wide band dco gap width dual band dco dbdco zero previously mentioned designs allow designer standard frequencies help direct multiplied frequencies trade power performance means low power consumption low frequency applications vice versa proposed designs based using digitally controlled capacitors current starving gates schmitt triggers critical points dco loop preserving coarse fine tunings non delay linearity factors clearly investigated resolved use new combined control unit simulations proposed designs performed hspice voltage cmos technology bit input coarse codes simulation evaluation results showed dual band dco jitter calculated mhz power consumption wide band overlap mode jitter measured mhz power consumption designs proper reconfigurable multi standard adpll designs
paper propose concept continuous time filter constant component exhibits short response time domain compared traditional time invariant filter improvement filter dynamics achieved result time varying parameters introduced filter structure designed filter applied system switches many distorted signals filtered fast possible paper review nature presents theoretical background proposed filter results simulations
correct diagnosis electrical circuits essential industrial plants article deals recognition method early fault detection induction motor described approach based patterns recognition acoustic signals specific induction motor analyzed patterns acoustic signals include information motor state analysis patterns conducted three states induction motor using fast fourier transform fft shortened method frequencies selection smofs linear support vector machine lsvm results calculations suggest method efficient also used diagnostic purposes
present study aims develop dynamic numerical model describe growth interactions shoot root systems eichhornia crassipes along irrigation canals nile delta egypt carrying study shoot root biomasses crassipes sampled monthly april november three irrigation canals nile delta using five randomly distributed quadrats canal two state variables shoot root systems biomasses considered follow growth crassipes biomass organ simulated incorporate net growth plant function photosynthesis respiration mortality translocation shoot root system validating model data nile delta verified using four independent sets published field data degrees brazil degrees mexico degrees usa degrees china level agreement simulated values actual field data indicated model capable simulating total biomass crassipes wide range latitudes global sensitivity analysis showed parameters used model sensitive maximum photosynthetic growth rate based results recommend following first crassipes used remove water pollution animal feed manure mulch production biogas pulp paper crassipes stands harvested peak net production second main purpose crassipes management suppress growth eradicate plant irrigation canal harvest point minimum net production
paper voltage mode biquadratic filter configuration using single operational transresistance amplifier otra proposed topology used synthesize lowpass highpass bandpass filter functions appropriate admittance choices component matching conditions components required synthesis filter functions workability proposed biquad configuration demonstrated pspice simulations using cmos process parameters provided mosis agilent
background little known course depression midlife women study aims identify factors distinguish risk factors persistent recurrent depression milder course across years follow methods black white premenopausal women aged enrolled study women health across nation pittsburgh site psychiatric interviews obtained information lifetime psychiatric diagnoses baseline occurrences depression annually identified four depression patterns persistent recurrent major depressive disorder mdd single episode mdd minor depression mind depression compared baseline risk factors persistent recurrent mdd group three results lifetime history major minor depression values upsetting life events previous year values likely reported women persistent recurrent group three persistent recurrent group likely report family history depression mind group report current sleep problems baseline single episode mdd group limitations small numbers women mind single episode mdd childhood maltreatment family depression history retrospectively reported conclusions persistent recurrent depression course common midlife addition personal family histories depression providers midlife health care recognize current sleep problems recent upsetting events strong risk factors pernicious depression course elsevier rights reserved
review aimed investigate possible protective deleterious effects polyphenol rich foods prf chronic diseases cardiovascular pregnant women along antioxidant anti inflammatory action great variety foods beverages herbal teas grape orange derivatives dark chocolate many others contain high concentrations flavonoids freely consumed general population humans prf consumption reduces lipid peroxidation several studies shown positive correlation increased consumption prf decrease incidence cardiovascular disease hand current studies suggested maternal ingestion prf especially third trimester pregnancy could associated fetal ductal constriction fetuses exposed type diet show higher ductal velocities lower pulsatility indexes well larger right ventricles exposed minimal amounts substances underlying mechanism involved conditions entirely elucidated seems result antioxidant anti inflammatory effects polyphenols pathway furthermore taking account deleterious effect late pregnancy numerous positive effects associated polyphenols dual behavior deserves attention particularly control dietary ingestion prf gestation line prf natural constituents human diet may represent risk fetal late pregnancy compared use nonsteroidal anti inflammatory drugs
vagal intramuscular arrays imas shown form complexes intramuscular interstitial cells cajal icc tested hypothesis associations vagal nerve endings icc arise fetal development intraganglionic laminar endings igles imas identified applying dioctadecyl tetramethylindocarbocyanineperchlorate dii vagal nerve trunks myenteric plexus intramuscular icc immunolabeled antibodies kit fetal early postnatal mice kit immunoreactive cells abundant primordial smooth muscle early icc networks discernable ongoing organization distribution vagal endings found change course development significantly putative igles prenatal compared postnatal period less imas prenatal compared postnatal period associations icc igles imas detected early maintained postnatal life findings suggest vagal fibers begin associate icc prenatal development future studies needed determine mechanisms vagal endings icc interact anat rec wiley periodicals inc
objectivesobesity associated significant morbidity mortality rates even modest weight loss may associated health benefits alpha lipoic acid ala naturally occurring antioxidant studies suggested anti obesity properties ala however results inconsistent purpose study conduct meta analysis effect ala weight body mass index bmi methodsa comprehensive systematic literature search identified articles randomized double blind placebo controlled studies involving ala conducted meta analysis mean weight bmi change differences ala placebo treatment groups resultsalpha lipoic acid treatment coincided statistically significant confidence interval greater mean weight loss compared placebo group significant overall mean bmi difference confidence interval found ala placebo groups meta regression analysis showed significance ala dose bmi weight changes study duration significantly affected bmi change weight change conclusionsalpha lipoic acid treatment showed small yet significant short term weight loss compared placebo research needed examine effect different doses long term benefits ala weight management
acquiring relevant business concepts crucial first step software project software experts domain experts wealth information buried within organization written documentation precious source concepts relationships attributes used model enterprise domain lack targeted extraction tools make perusing type resource lengthy costly process propose domain model focused extraction process aimed rapid discovery knowledge relevant software expert avoid undesirable noise high level linguistic tools process mainly composed positive negative base filters less error prone robust extracted candidates reordered using weight propagation algorithm based structural hints source documents tested french text corpora public organizations process performs times better statistical baseline relevant concept discovery new metric assess performance discovery speed relevant concepts introduced annotation gold standard definition software engineering oriented concepts knowledge extraction tasks also presented
introduction dietary fiber important component human diet since fiber type specific metabolic gastrointestinal function effects specific pathology choose optimum type fiber considering chemical physical physiological properties objective put partially hydrolyzed guar gum place complex framework dietary fiber review physicochemical properties possible mechanisms action well potential usefulness different clinical situations adult patients methods non systematic review medline results partially hydrolyzed guar gum phgg obtained partial enzymatic hydrolysis guar gum enzyme endo mannanase soluble highly fermentable fiber low viscosity fermentation ggph colon produces short chain fatty acids implicated main pathophysiological mechanisms responsible clinical effects use enteral nutrition associated diarrhea supported several studies recommendations scientific societies european society clinical nutrition metabolism american society parenteral enteral nutrition usefulness ggph studied many clinical situations diabetes hypercholesterolemia bacterial overgrowth etc promising results conclusions ggph useful management enteral nutrition associated diarrhea clinical situations quality studies would necessary order make concrete recommendations
cigarette smoking prenatal period investigated causative factor obstetric abnormalities lead cognitive behavioural changes associated schizophrenia aim study investigate behaviour ache activity brain structures adult rats exposed cigarette smoke prenatal period pregnant rats divided non pose non prenatal cigarette smoke exposure pcse prenatal cigarette smoke exposure groups post natal day rats received saline ketamine days subjected behavioural tasks locomotor activity task non pcse ketamine pcse ketamine groups exhibited increased locomotor activity compared saline group social interaction task non pcse ketamine pcse ketamine groups exhibited increased latency compared control groups however pcse ketamine group exhibited decreased latency compared non pcse ketamine group indicates cigarette exposure appeared decrease social deficits generated ketamine inhibitory avoidance task non pcse ketamine pcse pcse ketamine groups exhibited impairments working memory short term memory long term memory pre pulse inhibition ppi test cigarette smoke associated ketamine resulted impaired ppi pre pulse intensity groups compared control groups biochemical analysis ache activity brain structures increased ketamine groups however pcse ketamine group exhibited exacerbated effect brain structures present study indicates exposure cigarette smoke prenatal period may affect behaviour cerebral cholinergic structures adulthood elsevier inc rights reserved
study objective preliminary data effects prophylactic bilateral salpingectomy pbs show postoperative ovarian function preserved months surgery confirmation pbs safety ovarian function even many years surgery essential reassure medical community new strategy recently proposed prevention ovarian cancer least able avoid risk premature surgical menopause investigated whether addition pbs total laparoscopic hysterectomy tlh causes long term effects ovarian function design observational study canadian task force classification setting department obstetrics gynecology magna graecia university catanzaro italy patients seventy nine patients underwent tlh plus salpingectomy september september institution recalled submitted ovarian reserve evaluation february eight women refused participate follow study interventions ovarian age pbs patients determined ovage ovage catanzaro italy statistical model combines antimullerian hormone follicle stimulating hormone dimensional antral follicle count vascular index flow index vascular flow index values control group consisted large population healthy women intact uterus adnexa previously enrolled build ovage model comparisons ovarian ages pbs patients control group assessed analysis covariance linear statistical modeling measurements main results main outcome measurement differences behavior within ovage age relation pbs control women descriptive statistics enrolled pbs patients following age years ovage years follicle stimulating hormone antimullerian hormone dimensional antral follicle count vascular index flow index vascular flow index analysis covariance disclosed pbs control women exhibit different behaviors within ovage age relation conclusion according model addition pbs tlh late reproductive years modify ovarian age treated women years surgery aagl rights reserved
ventilation standards health indoor air quality adequately examined residential weatherization randomized trial showed ashrae houses ashrae houses influenced ventilation rates moisture balance indoor air quality self reported physical mental health outcomes average total airflow nearly twice high ashrae cfm volatile organic compounds formaldehyde carbon dioxide significantly reduced newer standard first floor radon marginally lower older standard formaldehyde significantly decreased humidity ashrae group half ashrae group using moisture balance metric radon higher basement lower first floor ashrae children group fewer headaches eczema skin allergies weatherization adults improvements psychological distress indoor air quality health improve weatherization accompanied ashrae residential ventilation standard ashrae standard greater improvements certain outcomes compared standard weatherization home repair energy conservation projects use newer ashrae standard improve indoor air quality health
according recent gartner report turkey considered one world outsourcing destinations since secured place list top countries information technology offshore services last decade country made excellent progress software sector reflected rise exports many countries article present overview advancement turkey software sector including current trends software process testing quality adoption agile methods along techno parks incentives provided government
many studies investigated factors affect susceptibility false memories however investigated role sleep deprivation formation false memories despite overwhelming evidence sleep deprivation impairs cognitive function examined relationship self reported sleep duration false memories effect total sleep deprivation susceptibility false memories found certain conditions sleep deprivation increase risk developing false memories specifically sleep deprivation increased false memories misinformation task participants sleep deprived event encoding significant effect deprivation occurred event encoding experiments first investigate effect sleep deprivation susceptibility false memories dire consequences
visible light positioning vlp widely believed cost effective answer growing demand real time indoor positioning however due high computational cost image processing existing vlc based systems fail deliver satisfactory performance terms positioning speed accuracy crucial performance indoor navigation paper proposes novel vlp solution provides accurate high speed indoor navigation via designs elaborate flicker free line coding scheme lightweight image processing algorithm addition solution advantage supporting flicker mitigation dimming important illumination android based system prototype developed field tests shelf smartphone experimental results show supports indoor positioning users moving speed addition achieve high accuracy computational time reduced single luminaire dual luminaries respectively
cloud computing new distributed computing paradigm consists provisioning infrastructure software platform resources services paradigm increasingly used deployment execution service based applications efficiently manage according autonomic computing approach service based applications associated autonomic managers monitor analyze monitoring data plan execute configuration action although last years autonomic management cloud services received increasing attention optimization autonomic managers ams assigned cloud services placement cloud remain well explored fact almost existing solutions autonomic computing interested modeling implementing autonomic environments without paying attention optimization address issue present paper novel approach optimize autonomic management service based applications consists minimizing cost allocated ams avoiding bottlenecks management cost placement cloud inter virtual machine communication cost propose two algorithms algorithm determines optimal number ams assigned services managed service based application algorithm approximates optimal placement ams cloud experiments conducted show efficiency finding
novel adaptive filter combining affine projection algorithm apa affine projection sign algorithm apsa proposed using impulsive noise indicator indicator proposed use apa component filter impulsive noise environments easily obtained convex combination schemes proposed algorithm achieves robustness impulsive noise regardless convergence state addition proposed algorithm exhibits fast convergence rate apa various noise environments simulation results verify proposed algorithm adequately combines advantages two component filters system identification scenarios elsevier rights reserved
water scarce resource arid regions hence water harvesting critically important regions many different means adopted including groundwater rainwater harvesting paper examines feasibility rainwater harvesting roof catchments arid regions australia ten representative locations arid regions australia selected also ten different sizes rainwater tanks ranging three different combinations water uses considered model developed simulate performance rainwater harvesting rwh system found reliability rwh system highly dependent mean annual rainfall location interest found tank provide reliability toilet laundry use depending location within australian arid regions current water price rwh system financially viable australian arid regions methodology adopted paper adapted similar arid regions world elsevier ltd rights reserved
vivo functional immunoassays elispot intracellular cytokine staining ics flow cytometry crucial tools vaccine development identification novel immunogenic targets immunological assessment samples clinical trials cryopreservation subsequent thawing pbmcs via validated processes become mainstay clinical trials due processing restrictions inherent disparate location capacity trial centres also need standardize biological assays central testing facilities logistical financial requirement batch process samples multiple study timepoints also key used elispot ics assays assess antigen specific immunogenicity blood samples taken subjects enrolled phase malaria heterologous prime boost vaccine trial showed freeze thaw process result fold reduction malaria antigen specific ifn gamma producing effector populations pbmc samples taken post vaccination also demonstrated peptide responsive cells relatively unaffected well cell populations produce ifn gamma findings contribute growing body data could consolidated synthesised guidelines clinical trials aim increasing efficiency vaccine development pipelines authors published elsevier ltd
article establish new general traveling wave solutions space time fractional klein gordon equation quadratic nonlinearity space time fractional breaking soliton equations using modified simple equation method proposed method powerful effective solve nonlinear space time fractional differential equations modified riemann liouville derivative
previous cross sectional studies demonstrated higher incidence dehydration patients admitted stroke suggesting possible association however temporality association well established examined whether dehydration increases risk ischemic stroke patients recent hospitalization atrial fibrillation data myocardial infarction data acquisition system midas repository patient records new jersey hospitals hospitalizations estimates association hospitalization without dehydration ischemic stroke within days post discharge determined using log linear multivariable modeling adjusting socio demographic factors comorbid conditions within days discharge patients years old comorbid dehydration higher risk ischemic stroke compared patients without comorbid dehydration adjusted risk ratio arr confidence interval eighteen patients higher risk ischemic stroke days post discharge arr difference risk stroke patients without prior dehydration days post discharge also found difference risk ischemic stroke time period patients dehydration may significant risk factor ischemic stroke patients
background researchers investigating lung diseases asthma questioned whether certain compounds previously reported exhaled breath condensate ebc originate saliva contamination moreover despite increasing use omics profiling studies constituents ebc remain largely uncharacterized present study aims define usefulness ebc investigating lung disease comparing ebc saliva saliva contaminated ebc using targeted untargeted mass spectrometry potential metabolite loss adsorption ebc sample collection tubes methods liquid chromatography mass spectrometry used analyze samples individuals three different cohorts levels amino acids eicosanoids two classes molecules previously reported ebc saliva measured using targeted cohort used examine contamination ebc saliva samples cohort consisted clean ebc saliva contaminated ebc clean saliva healthy volunteers samples analyzed using untargeted cohort used compare eicosanoid levels matched ebc saliva collected asthmatic subjects samples analyzed using targeted untargeted cohort samples consisted clean ebc collected subjects including smokers non smokers used independently confirm findings samples analyzed using targeted untargeted proteomics addition human samples house developed nebulizing system used determine potential ebc samples contaminated saliva results metabolites detected ebc saliva specific ebc however ebc samples concentrated fold achieve level sensitivity amino acid concentrations ranged clean ebc saliva contaminated ebc saliva eicosanoid concentration ranges order magnitude lower clean ebc saliva contaminated ebc saliva although sample size replication cohort cohort allow statistical comparisons two proteins eicosanoids detected smoker non smoker clean ebc conclusions conclude metabolites present detectable ebc using however large starting volume sample required
vaccine induced protection influenza optimal however suggested vaccine may reduce severity symptoms among develop illness despite vaccinated tested hypothesis within countrywide sentinel general practitioners based surveillance system france included individuals aged years older vaccinated influenza consulted general practitioner acute respiratory infection ari patients taken nasopharyngeal swab information collected demographic characteristics symptoms disease onset specimens tested respiratory viruses positive influenza virus type subtype determined compared average maximum temperature frequency symptom non vaccinated vaccinated influenza patients used logistic regression models calculate odds presenting symptom vaccinated non vaccinated patients adjusting age group virus sub type season overall ari patients tested positive influenza virus caused majority cases followed influenza subtyped viruses compared non vaccinated influenza patients vaccinated slightly reduced maximum temperature presented less frequently myalgia shivering headache stratified analyses observed effect limited patients infected type viruses adjusting age group virus sub type season difference remained statistically significant headache less frequent among vaccinated individuals odds ratio confidence intervals conclusion vaccine found modestly associated less severe clinical presentation influenza among elderly findings reinforce need influenza vaccines providing better protection authors published elsevier ltd
petroleum unconventional reserves making increasingly important contribution transportation fuel supply generally expensive greater environmental burdens petroleum conventional sources life cycle assessments lcas alternative fuel vehicle technologies typically consider conventional internal combustion engine vehicles fueled gasoline produced average petroleum slate used refineries baseline large scale deployment alternative fuel vehicle technologies decrease petroleum demand lead decreased production economic margin unconventional oil considered current lcas marginal petroleum resources larger impacts average petroleum resources environmental benefits petroleum demand reduction underestimated current modeling approaches often models include consequential based impacts indirect land use change biofuels exclude others avoided unconventional oil production approach inconsistent provide robust basis public policy private investment strategy decisions provide example illustrate potential scale impacts research needed establish quantify marginal effects incorporate lcas conventional alternative fuel vehicle technologies
varistor equivalent electrical network generally used cad software presented based pspice model already presented psim model valid static regime developed since correct parameter estimation important model valid transient regimes detailed varistor electrostatic capacity determination future model improvements presented
well known backpropagation learning algorithm implemented field programmable gate array fpga board microcontroller focusing obtaining efficient implementations terms resource usage computational speed algorithm implemented cases using training validation testing scheme order avoid overfitting problems case fpga implementation new neuron representation reduces drastically resource usage introduced combining input first hidden layer units single module time division multiplexing scheme implemented carrying product computations taking advantage built digital signal processor cores implementations floating point data type representation normally used personal computer changed efficient one based fixed point scheme reducing system memory variable usage leading increase computation speed results show modifications proposed produced clear increase computation speed comparison standard based implementation demonstrating usefulness intrinsic parallelism fpgas neurocomputational tasks suitability implementations algorithm application real world problems
objective compare regional nicotinic cholinergic receptor binding older adults alzheimer disease healthy older adults vivo assess relationships receptor binding clinical symptoms methods using cross sectional positron emission tomography pet neuroimaging structured clinical assessment outpatients mild moderate healthy older adults without cognitive complaints group studied pet imaging alpha beta nicotinic cholinergic receptor binding using fluoro azetidinylmethoxy pyridine clinical measures global cognition attention processing speed verbal memory visuospatial memory neuropsychiatric symptoms used results binding lower group compared group medial thalamus medial temporal cortex anterior cingulate insula opercula inferior caudate brainstem corrected cluster binding associated cognition group significant inverse correlations binding thalamus left right hippocampus left right trails score group inverse correlation binding anterior cingulate left right neurobehavioral rating scale agitation disinhibition factor score conclusion cholinergic receptor binding reduced specific brain regions mild moderate related neuropsychiatric symptoms among healthy older adults lower receptor binding may associated slower processing speed cholinergic receptor binding vivo may reveal links key brain changes associated aging may provide potential molecular treatment target
compacted clay liners vulnerable desiccation cracking exposed atmospheric conditions extended periods time three clayey soils typically used landfill liners studied relatively large scale containers exposed real atmospheric conditions full annual cycle desiccation cracking particularly variation depth cracks examined soil pairs one set directly exposed atmospheric conditions covered white separator geotextile cracks started grow deeper time variations rainfall events months followed significant increase later smaller crack depths observed soil lowest plasticity index using geotextile cover resulted reduction average crack depth hydraulic conductivity soils increased end experiment greater increase soils deeper cracks american society civil engineers
randomized double blind double dummy phase relief trial evaluated polycythaemia vera related symptoms patients well controlled stable dose hydroxycarbamide also termed hydroxyurea reported related symptoms patients randomized ruxolitinib bid hydroxycarbamide prerandomization dose schedule crossover ruxolitinib permitted week primary endpoint improvement baseline myeloproliferative neoplasm symptom assessment form total symptom score cytokine symptom cluster tss sum tiredness itching muscle aches night sweats sweats awake week achieved ruxolitinib hydroxycarbamide treated patients respectively odds ratio confidence interval primary endpoint achieved subgroup maintained hydroxycarbamide dose baseline weeks post hoc analysis primary endpoint achieved patients stable screening baseline tss scores ratio receiving ruxolitinib hydroxycarbamide ruxolitinib treatment unblinding associated continued symptom score improvements adverse events primarily grades unexpected safety signals ruxolitinib associated nonsignificant trend towards improved related symptoms versus hydroxycarbamide although unexpectedly large proportion patients maintained hydroxycarbamide dose reported symptom improvement
aims studies examined experiences carers people psychosis using representative sample aiming obtain generalisable results concerning carers context increased emphasis involving carers australian mental health service delivery policy frameworks study recruited carers within second australian national survey psychotic disorders survey high impact psychosis ship given ship participants long term illness extended relationships carers health wellbeing carers group expected relatively stable however since unknown whether carers health wellbeing would change main aim explore change stability carers health wellbeing relationship changes experienced individual carers corresponding ship participants functioning time methods ninety eight caregivers ship participants recruited baseline completed validated instruments assessing health wellbeing seventy eight carers interviewed year follow clinical factors extracted ship database wilcoxon matched pairs signed rank test test used analyse changes variables time cross lagged analyses conducted identify possible causative relationships changes ship participant carer variables results substantial percentage carers experienced social isolation psychological distress poorer quality life population norms statistically significant changes baseline follow scores almost carers health wellbeing variables poorer perception quality life relation physical health year cross lagged analyses suggested poorer functioning people psychosis influenced carers social isolation grief psychological distress conclusions findings show carers perception health wellbeing improve within current mental health service delivery frameworks time carer persistently poor health wellbeing suggests pressing need enhance services improve carers health wellbeing especially physical health functioning people psychosis support
literature dealing inclusion children autism spectrum disorder asd mainstream schools increased recent years propelled argument improve quality life educational performance social development included children area research currently important one development policy practice literature inclusion dealing inclusion children asd limited implementation inclusion preceded research current study investigated whether children mainstream placements show enhanced performance relative specialist provisions study used combination primary secondary data analysis explore impact inclusion children asd four authorities south east england results suggest mainstream children greater academic success children specialist provision study suggests number specific provisions involved promoting success speech language therapy impact learning support assistants also reviewed discussed
scholars examined psychopathology correlates sex work suggested sex work may reflect manifestations impulsive antisocial psychopathic traits reckless disregard delinquency women men current work examined relative contributions drug dependence distinct psychopathic features relation traditional forms sex work prostitution women along gender differences psychopathy relationships casual forms sex exchange trading sex necessities study included community dwelling women offenders study included participants women histories drug use violence participants completed psychopathy checklist screening version prostitution measured self report public record data across studies sex exchange study assessed using questionnaire based prior research sexual risk taking findings across studies demonstrated although psychopathic traits particularly impulsive antisocial features associated prostitution women use drugs drug dependence moderate relationship psychopathic traits prostitution women analyses study data revealed impulsive antisocial traits associated sex exchange low high levels interpersonal affective traits across participants well interpersonal affective traits significantly positively related sex exchange men significantly negatively related women sum impulsive antisocial traits related prostitution among women suggesting women may manifest traits within intimate contexts moreover findings indicated gender differences manifestation interpersonal affective traits within sexual exchange contexts
introduction left atrial pulmonary vein isolation pvi accepted treatment option patients symptomatic atrial fibrillation procedure complicated stroke silent cerebral embolism online measurement microembolic signals mess transcranial doppler tcd may useful characterizing thromboembolic burden pvi prospective multicenter trial investigated burden characteristics composition mes left atrial catheter ablation using variety catheter technologies materials methods pvi performed total patients using circular shaped multielectrode pulmonary vein ablation catheter pvac technology irrigated radiofrequency irf cryoballoon technology patients tcd used detect total mes burden sustained thromboembolic showers tess tes site ablation within left atrium registered mes composition classified manually solid gaseous equivocal line expert assessment results total mes burden higher using irf compared showed tendency toward higher burden using irf compared pvac tes occurred often using pvac compared irf frequently ablation performed close left superior pulmonary vein lspv mes characterized definitely solid clearly gaseous equivocal discussion investigated burden characteristics mes left atrial catheter ablation ablation techniques applied study generated relevant number mes significant difference total mes burden using irf compared tendency toward higher burden using irf compared pvac highest tes burden found pvac group particularly ablation close lspv composition thromboembolic particles balanced impact mes tes composition thromboembolic particles neurological outcome needs evaluated
residential domestic hot water energy consumption represented household heating demand improvement building insulation envelope domestic hot water contribution energy consumption expected increase significantly values single family buildings almost multifamily buildings energy currently lost environment recovered waste water heat recovery systems inside buildings building solutions publications field focus shower heat recovery waste water heat source heat pumps detailed impact waste water heat recovery city scale aggregating building data addressed yet furthermore waste water heat recovery potential relevance yet quantified function specific inhabitant household numbers end use occurrence building type age method quantify building specific energy cost energy saving potentials based pinch analysis urban scale building waste water heat recovery systems therefore proposed complementary method spatially allocate characterise grey water streams thermal load temperature levels function building specificities also developed methods applied two case studies first retrofitting solution city luxembourg second optimisation measure high efficiency residential buildings grey water heat recovery would reduce residential fuel consumption city integrated approach combining grey water heat recovery hot water preheating heat pump yields electricity savings passive single family houses multifamily buildings respectively detailed characterisation various grey water streams function inhabitant number end use occurrence quantification energy savings costs heat recovery improved outcomes urban energy cost assessments concerning grey water heat recovery specific results building level aggregated considered geographical scope proposed method therefore complements current urban energy cost assessments detailed integration building grey water heat recovery systems published elsevier ltd
aging buildings represent significant percentage existing buildings often urgent need upgrading improve operational economic environmental performance owners buildings often seek identify implement building upgrade measures capable improving building sustainability well achieving certification various green building rating systems leadership energy environmental design leed order support decision makers promoting building sustainability achieving leed certification existing building paper presents development novel optimization model capable minimizing required upgrade cost achieving desired leed certification level silver gold model designed identify cost effective building measures plans performance achieve specified leed certification existing buildings keeping required upgrade cost minimum optimization model implemented using genetic algorithm due capabilities identifying optimal solutions type problem reasonable computational time efficiently accurately modeling specific optimization problem least number decision variables constraints project case study rest area building used illustrate optimization model demonstrate novel unique capabilities primary contribution research makes body knowledge new methodology optimizing selection building upgrade measures achieve leed certification existing building minimum upgrade cost american society civil engineers
treewatch net initiative developed watch trees grow function real time water carbon monitoring modeling network high quality measurements sap flow stem diameter variation collected individual trees automated data processing using cloud service enables instant visualization water movement radial stem growth used demonstrate sensitivity trees changing weather conditions drought heat waves heavy rain showers treewatch net true innovation lies use high precision harmonized data also parameterize process based tree models real time makes displaying much needed mechanisms underlying tree responses climate change possible continuous simulation turgor describe growth processes long term time series hydraulic resistance assess drought vulnerability real time opportunities approach offers treewatch net developed view complementary existing forest monitoring networks aim contribute existing dynamic global vegetation models provides high quality data real time simulations order advance research impact climate change biological response trees forests besides application natural forests answer climate change related scientific political questions also envision broader societal application treewatch net selecting trees nature reserves public areas cities university areas schoolyards parks teach youngsters create public awareness effects changing weather conditions trees forests era climate change
lapping symptoms overactive bladder oab urinary tract infection uti often complicate diagnosis contribute overprescription antibiotics inflammatory response shared characteristic uti oab hypothesized molecular differences inflammatory response seen urine help discriminate oab uti subjects age range either sex recruited urine analysis study urine specimens available uti patients positive dipstick test antibiotic treatment six patients also provided urine completion antibiotic treatment subjects cohorts oab asymptomatic controls negative dipstick test urinary chemokines measured milliplex map human cytokine chemokine immunoassay association uti oab determined univariate multivariate statistics significant elevation cxcl cxcl cxcl together reduced levels receptor antagonist sil seen uti relative oab asymptomatic controls elevated cxcl urine levels predicted uti odds ratio showed specificity sensitivity postantibiotic treatment reduction seen cxc chemokines significant reduction cxcl strong association cxcl cxcl uti oab indicates mechanistic differences signaling pathways driving inflammation secondary infection uti compared lack infection oab urinary chemokines highlight molecular differences paracrine signaling driving overlapping symptoms uti oab
biological drugs pharmaceuticals manufactured using biotechnology methods may target specific cytokines cytokine receptors surface molecules modulate immunological response organism psoriasis common cutaneous disease biological drugs evaluated widely accepted clinical practice secukinumab monoclonal antibody targeting extensively researched clinical trials registered treating moderate severe plaque psoriasis performed literature search pubmed database pharmacology secukinumab randomized clinical trials investigating efficacy safety treating plaque psoriasis comparison placebo biological drugs etanercept ustekinumab administration secukinumab psoriatic subjects resulted subjective objective disease parameters reduction exhibiting high safety profile secukinumab effective drug favorable safety profile already taken important position managing plaque psoriasis clinical practice
paper describes energy management controller design mid sized vehicle driven fuel cell battery plug hybrid powertrain experimentally validated hight temperature polymer electrolyte membrane fuel cell model used power management strategy derived application pontryagin minimum principle control parameter adapted using feedback information state charge total trip length forecast function moving average past information driving cycle speed strategy propose aims achieving real time suboptimal solution control problem cast minimization consumed fuel vehicle also equipped auto thermal reformer order minimize hydrogen buffer size control algorithm subject constraints maximum hydrogen buffer level comparative analysis proposed strategy optimal one conducted results reported obtained fuel consumptions also compared obtained vehicle powered internal combustion engine plug hybrid electric powertrain elsevier ltd rights reserved
borderline personality disorder bpd characterized severe pattern instability emotional regulation interpersonal relationships identity impulse control functions related prefrontal cortex pfc since pfc shows rich anatomical connectivity cerebellum functionality cerebellar pfc axis may impact bpd study investigated potential involvement cerebello thalamo cortical connections impulsive reactions pre post stimulation design bpd patients healthy controls performed affective task agn assessing information processing biases positive negative stimuli repetitive transcranial magnetic stimulation rtms min resting motor threshold rmt left lateral cerebellum agn task consisted four blocks requiring associative capacities increasing complexity bpd patients performed significantly worse especially cognitive demands high third fourth block performance approached rtms rtms almost ineffective evident effect rtms complex associative tasks might occurred since cerebellum deeply involved integration coordination different stimuli hypothesize bpd patients cerebello thalamo cortical communication altered resulting emotional dysregulation disturbed impulse control rtms left cerebellum might interfered existing functional connections exerting facilitating effect pfc control
purpose one largest energy consumers transport sector significant impacts environment shenzhen developed megacity south china plays leadership role promoting development energy efficient vehicles china methods paper aims assess carbon footprint shenzhen via streamlined life cycle assessment method consequently current environmental performance evaluated improvement potentials examined results discussion results show gained rapid growth past decade annual rate closely corresponding growth gross domestic product shenzhen total estimated million tons ranging road based freight transport accounts largest share emissions significant contributors sector light duty trucks urban public transport bus service passenger air transport meanwhile study took new energy vehicles consideration order explore range mitigation potential shenzhen potential carbon abatement significant comparison impact growth derived increasing freight passenger transport based assumption transport intensity annual growth rate maintain current levels conclusions study offers useful approach evaluate available options sustainable transport system planning shenzhen carbon emissions reductions policies technological innovations essential facilitate transition low carbon addition methodology developed study could used assessing sectors
purpose review gastrointestinal toxicities commonly reported following treatment proteasome inhibitors first generation proteasome inhibitor bortezomib induces significant gastrointestinal side effects including nausea vomiting diarrhoea constipation occurring patients despite development safer proteasome inhibitors carfilzomib gastrointestinal toxicities remain common side effects review aims summarize previous literature proteasome inhibitor induced gastrointestinal toxicities report recent updates field investigate possible mechanisms toxicity recent findings updates literature included direct comparison safety approved proteasome inhibitors bortezomib carfilzomib reporting less neurotoxicity similar gastrointestinal toxicity carfilzomib compared bortezomib many recent studies investigated safety orally bioavailable proteasome inhibitors ixazomib oprozomib however little progress made understanding possible mechanisms proteasome inhibitor induced gastrointestinal toxicities summary although recent studies continued report gastrointestinal toxicities resulting proteasome inhibitor treatment particularly combined agents administered orally mechanisms proteasome inhibitor induced gut toxicity remain largely unexplored studies needed investigate pathophysiology toxicity improve safety existing novel proteasome inhibitors
much research birth order focused individual differences personality traits relatively studies focused aspects social behavior sibling conflict however one would predict differences parental investment niche differentiation shape personality differences siblings would also influence social relationships particular middleborns may likely prioritize non kin relationships study investigated impact birth order number measures prosocial behavior results suggest birth order moderate effect prosociality later birth orders exhibit greater prosociality however linear quadratic effects significant quadratic negative indicating greatest increase prosociality seen first secondborns rate change decelerates birth order prosociality increase elsevier ltd rights reserved
background stress shown negatively impact surgical performance surgical novices particularly susceptible effects mental skills psychological strategies designed enhance performance reduce impact stress consistently facilitate ideal mental conditions enable performers perform best mental skills used routinely high stress domains navy seals military pilots elite athletes forth facilitate optimal performance challenging situations developed novel mental skills curriculum msc aid surgical trainees optimizing performance stressful conditions purpose study determine effectiveness msc reducing novices stress methods msc implemented convenience sample surgical novices two stress tests administered completion msc assess effectiveness reducing trainee stress trier social stress test tsst validated method measuring participants stress responses implemented giving participants min prepare impromptu presentation min present front medical education expert would assessing connor tweezer dexterity test otdt test fine motor dexterity participants competed small groups would complete test fastest competition shown cause acute stress performers assess stress heart rate perceived stress stai perceived workload nasa tlx completed testing sessions results nine novices age women completed msc increased significantly resting performance tsst early competition min elapsed time immediately completing task however participants perceived less stress immediately tsst otdt tests completion msc addition reported significantly less workload second otdt administration showed trend toward faster completion test conclusions novel msc effective reducing surgical novices perceived stress workload two comprehensive stress tests although statistically significant participant enhanced performance otdt encouraging curriculum may valuable help inexperienced learners reduce stress variety situations related learning performing surgical skills additional research using larger sample size currently underway validate effectiveness curriculum elsevier inc rights reserved
conventional approach designing vaccine particular disease involves stimulation immune system using whole pathogen responsible disease post genomic era major challenge identify antigenic regions epitopes stimulate different arms immune system past two decades numerous methods databases developed designing vaccine immunotherapy various pathogen causing diseases review describes various computational resources important designing subunit vaccines epitope based immunotherapy first different immunological databases described maintain epitopes antigens vaccine targets followed silico tools used predicting linear conformational cell epitopes required activating humoral immunity finally information cell epitope prediction methods provided includes indirect methods like prediction major histocompatibility complex transporter associated protein binders different studies validating predicted epitopes also examined critically review enlists novel silico resources tools available predicting humoral cell mediated immune potential predicted epitopes could used designing epitope based vaccines immunotherapy may activate adaptive immunity authors emphasized need develop tools prediction adjuvants activate innate adaptive immune system simultaneously addition attention also given novel prediction methods predict general therapeutic properties peptides like half life cytotoxicity immune toxicity
implement practicality fault diagnosis methods medium scale grounding grid fault diagnosis model established combining electrical network theory sensitivity analysis paper simulation analysis fault diagnosis new method used select node pairs calculate corrosion situation grounding grid presented based method fault branch grounding grid efficiently judged topology diagram port resistance without power failure excavation large area field test carried electrical substations using diagnosis method result identical diagnosis results indicating diagnosis method engineering practicality
tests physical vapour deposition pvd coatings performed past nasa glenn research center grc real fluid film bearing environment revealed inconsistencies coating behaviour currently new lot bearings improved diamond like carbon dlc coating tested oil tests revealed improved coating performance new bearing lot previously examined cases order check consistency coating performance bearings new lot ran cumulative hours without oil supply coating analyses tests real fluid film bearing environment performed nasa grc investigations additionally conducted means innovative indentation technique related finite element method simulations coatings bearings one already tested real environment conditions one new laboratory machine tools manufacturing engineering aristotle university thessaloniki greece
aim work determine antioxidant capacities neuroprotective skin care antidiabetic effects fatty acid composition anchusa undulata subsp hybrida antioxidant activity screened four different test systems including total antioxidant antiradical reducing power metal chelating activities neuroprotective potential determined anticholinesterase inhibitor assay tyrosinase inhibitory activity tested detect skin care effect antidiabetic effects evaluated alpha amylase alpha glucosidase inhibitory assays inhibitory activities acetycholinesterase butyrylcholinesterase tyrosinase alpha amylase alpha glucosidase enzymes observed mol galaes mmol kaes mmol aces extract respectively amount total phenolics flavonoids found gaes qes extract respectively twenty three fatty acids found aerial parts oleic acid total fatty acids abundant followed linoleic total fatty acids palmitic acids total fatty acids
matrix computations fundamental ubiquitous computational science result frequently used numerous disciplines scientific computing engineering due high computational complexity matrix operations makes critical performance large number applications efficient execution distributed environments becomes crucial issue work proposes novel approach distributing sparse matrix arithmetic operations computer clusters aiming speeding processing high dimensional matrices approach focuses split operations independent parallel tasks considering intrinsic characteristics distinguish type operation particular matrices involved approach applied commonly used arithmetic operations matrices performance presented approach evaluated considering high dimensional text feature selection approach two real world datasets experimental evaluation showed proposed approach helped significantly reduce computing times big scale matrix operations compared serial multi thread implementations well several linear algebra software libraries
article juxtaposes results unmanned aerial vehicle uav terrestrial laser scanning tls survey conducted determine land relief determination terrain relief task requires precision order example map natural anthropogenic uplifts subsidences land surface one problems encountered using either method determine relief impact vegetation covering given site determination height site surface discussed case site covered mostly low vegetation grass one part mowed whereas high attempt made filter point clouds way leave points represented land surface eliminate whose height substantially affected surrounding vegetation reference land surface determined dense measurements obtained means tacheometer rod mounted reflector method ensures impact vegetation minimized comparison obtained accuracy levels costs effort related method leads conclusion efficient use uav use tls dense land relief modeling international society photogrammetry remote sensing inc isprs published elsevier rights reserved
high levels exercise athletes result temporary immunosuppression could increase susceptibility upper respiratory tract infections understanding immunological mechanisms responsible phenomenon could enable optimization training schemes elite athletes avoidance infection related episodes absence sports championships aim study detect genes may responsible modulation individual susceptibility infections blood saliva samples collected healthy medically examined kayakers females males aged years samples taken morning overnight fasting seated position elisa method used determine levels secretory immunoglobulin siga interleukin whole genome expression blood assessed using microarrays study reveal significant correlation genome expression siga concentration however low expression gene involved protection common cold secretoglobin scgbc detected athletes high concentrations corrected fold change results suggest blood expression scgbc gene might marker susceptibility upper respiratory tract infections athletes
objective previous studies report reduced interoceptive abilities anorexia nervosa using various methods recent research suggests different levels interoceptive processes aiming different subdomains interoceptive abilities must distinguished levels differentially affected two important levels refer interoceptive accuracy derived objective performance tasks heartbeat detection task interoceptive sensibility assessed self report lack studies investigating examining time course therapy aim pilot study evaluate different interoceptive processes especially time course therapy methods fifteen patients restricting type psychosomatic clinic windach investigated three times standardized cognitive behavioral therapy compared matched healthy controls assessed ulm university comparable design participants performed heartbeat detection task examining completed standard psychological assessments including assessment results patients showed significantly decreased weight higher levels depression reduced compared healthy controls following therapy patients recovered terms weight depression symptomatology descriptive trend recovering observed discussion findings suggest interoceptive deficits present recovered patients therefore investigations needed patients differentiating relapsed recovered patients specific training methods improve interoceptive processes
magnetorheological elastomer mre known smart material whose mechanical properties changed external magnetic fields aim paper present results studies magnetoviscoelasticity properties new developed mre consisting carbonyl iron particles displaced matrix made bromobutyl rubber mre samples fabricated constant magnetic field mre specimens experimented shear mode investigate dynamic viscoelastic properties sinusoidal loadings different displacement amplitudes frequencies tests loading case carried four different magnetic field strengths stepwise results dynamic properties mre samples obtained terms experimentally determined shear storage modulus loss factor results demonstrate mres properties variable stiffness high loss factor
conflicting evidence contribution maternal depression family adversity depression experienced offspring maternal depression family adversity related need determine independently contribute offspring depression data long running prospective birth cohort study mater university queensland study pregnancy outcomes musp study offspring followed years age first examine association maternal depression family adversity period pregnancy child reaching adulthood consider extent maternal depression family adversity trajectories period predict cidi dsm episodes depression offspring mothers years age find strong directional association maternal depression family experiences adverse life events entire period child home adjustment children reared family experiencing high levels adverse life events likely experience lifetime ever dsm diagnosis depression likely experienced multiple episodes lifetime ever depression likely report first episode depression younger age findings suggest association maternal depression offspring depression appears partly attributable higher levels family adversity characteristic depressed mothers elsevier ltd rights reserved
study question efficacy maintaining restoring non pregnant status low dose mifepristone combined misoprostol administered expected menstruation summary answer low dose mifepristone misoprostol administered time expected menstruation effective safe maintaining restoring non pregnant status obvious menstrual disturbance known already menstrual regulation involves medical mechanical stimulation uterine sloughing women weeks menstrual delay low dose mifepristone plus misoprostol efficacious termination ultra early pregnancy days amenorrhoea obvious menstrual disturbance study design size duration total women fulfilled criteria recruited seventeen women dropped deciding remain pregnant others lost follow thus data women completed procedure included analyses participants enrolled time menstrual cycle administered medication day expected menstruation end study defined per patient basis date completion post treatment menstrual cycle primary outcome efficacy abortion induction pregnant women menstrual regulation non pregnant women participants setting methods women regular menstrual cycles days voluntarily recruited study february december serum beta hcg measured mifepristone intake mifepristone administered orally day expected menstruation misoprostol administered orally day expected menstruation efficacy disturbance bleeding patterns treatment post treatment cycles satisfaction treatment subsequent contraception preference analysed main results role chance retrospective analysis serum beta hcg levels admission indicated women pregnant success rate pregnancy termination two women ongoing pregnancy subsequently terminated surgically overall bleeding induction rate within days pregnant participants non pregnant participants pregnant non pregnant participants experienced significant menstrual disturbance treatment versus post treatment versus menstrual cycle general rate satisfaction treatment generally participants preferred use regimen routine contraception method versus preferred use remedy pregnancy prevention unprotected sex limitations reasons caution study participants recruited single region studies include participants multiple centres different cities nations given uncertain efficacy regimen reuse assessment efficacy based solely first treatment administration studies larger samples long term follow may provide data whether repeated use regimen hampers efficacy wider implications findings menstrual regulation low dose mifepristone misoprostol expected menstruation efficacious highly acceptable maintain restore non pregnant status may potential routine contraception
paper presents improved phase leg power loop design enhance mode lateral structure gallium nitride gan transistors static characterization results gan transistor presented determine design parameters gate driver circuits control common mode noise current propagation considered gate driver design optimizing power distribution grounding structure gate driver digital control circuits differentiating propagation path impedance digital control circuits power supply circuits conductive noise propagate power supply path protect digital control circuits order reduce current commutation loop inductance within gan phase leg improved power loop design vertical structure proposed lateral structure gan transistors significantly reduce power loop inductance compared conventional lateral power loop design design verified experiments phase leg prototype prove performance proposed phase leg overvoltage reduction current transition along less cross coupling power loop gate loop compared conventional lateral power loop design full bridge voltage source inverter implemented designed phase leg tested emi noise measurement verifies effectiveness propagation path control
background overactive bladder oab common condition significant impact patients health related quality life associated substantial economic burden healthcare systems onabotulinumtoxina well established efficacy safety profile treatment oab however economic impact using onabotulinumtoxina well described methods economic model developed assess budget impact associated oab treatment france germany italy spain using onabotulinumtoxina alongside best supportive care bsc comprising incontinence pads anticholinergic use clean intermittent catheterisation cic bsc alone model time horizon spanned years included direct costs associated treatment bsc adverse events results per patients country use onabotulinumtoxina resulted estimated cost savings sic italy sic spain sic cost increases sic france sic germany largely due day case inpatient administration respectively projecting results population individuals aged years gave national budget saving estimates sic sic sic spain italy respectively compared cost increases sic sic france germany respectively anticholinergic treatment incontinence pads largest contributors overall spending oab management onabotulinumtoxina use increased remained four five scenarios onabotulinumtoxina use increased decreased resource use equivalent cost offsets ranging sic sic per population conclusions three five countries investigated use onabotulinumtoxina addition bsc shown result healthcare budget cost savings years scenario analyses showed increased costs germany france largely attributable treatment setting rather onabotulinumtoxina acquisition costs
every fifth pregnant woman affected allergies especially rhinitis asthma allergic symptoms existing pregnancy may either attenuated equally often promoted pregnancy optimal allergy asthma diagnosis management pregnancy vital ensure welfare mother baby allergy diagnosis pregnancy preferentially anamnestic investigation well vitro testing applied whereas skin testing provocation tests postponed birth pregnant women confirmed allergy avoid exposure consumption offending allergen allergen immunotherapy initiated pregnancy patients immunotherapy since pregnancy maintenance treatment may continued allergen dose increased applicable medications asthma rhinitis skin symptoms pregnancy discussed listed conclusion allergies pregnancy preferentially diagnosed vitro ait may continued started symptomatic medications must carefully selected iii management asthma allergic diseases important pregnancy welfare mother child
model dynamics self regulation describes two patterns commitment progress individuals may follow selecting goal directed behaviors commitment pattern individuals likely highlight congruent goal behavior choices progress pattern individuals likely balance incongruent congruent goal behavior choices study set test model context problematic internet usage primed problematic internet usage sample undergraduate university students completed online survey rating value internet academic social related behaviors across three conditions three conditions paired behaviors appeared complement appeared compete presented individually results showed internet behaviors rated highly presented complementary presented competing supporting prediction presentation format primes progress commitment frameworks leads higher ratings incongruent goal behavior progress condition results fully support model predictions regarding congruent goal behavior predicted direction small moderate effect sizes study may inform clinical interventions suggesting individuals experiencing issues problematic internet usage would benefit framing self regulatory dilemmas competing format elsevier ltd rights reserved
cognitive models anxiety propose heightened anxiety vulnerability characterized tendency interpret ambiguous situations threatening presence interpretive bias confirmed younger adults using assessment measures bypass limitations self report objectively assess interpretive processing recent pioneering study published sought determine whether anxiety linked interpretive bias also evident older adults however evidence supporting hypothesis comes self report measures memory measures present study designed provide stronger test hypothesis objectively assessing interpretive process high low trait anxious older adults using text comprehension approach circumvents reliance self report memory measures findings fully consistent hypothesis older adults higher levels trait anxiety compared lower levels trait anxiety impose threatening meanings ambiguous information findings provide first evidence assessment approach overcomes limitations self report memory measures elevated anxiety vulnerability older adults characterized negative interpretive bias
cells traditionally viewed either independently moving entities somewhat static parts tissues however clear many cases multiple cells coordinate motions move collective entities well studied examples comprise development events well physiological pathological situations different vivo model systems also investigated several recent advances taken place interface biology physics benefitted progress imaging microscopy use microfabrication techniques well introduction quantitative tools models review interesting developments quantitative cell biology also provide rich examples collective equilibrium motion
paper overviews various methods data acquisition gem detectors presented currently working systems tokamaks data acquisition methods divided two parts first part devoted analog signal processing describes different approaches signals acquisition pulse amplifying shaping asic use delay lines digital data acquisition part describes presently used high speed interfaces system standards described also different approaches data handling online analysis data reduction system topologies
sexual risk behaviors common among college students differences year students explicitly tested survey data unmarried sexually active minnesota college students used multilevel logistic regression models test differences eight high risk sexual health behaviors outcomes students attending year colleges odds sex without condom sex without reliable birth control unplanned pregnancy stis significantly lower among year students year students adjusting demographic covariates health promotion approaches targeted needs year students may needed example messaging outreach efforts encouraging condom use may especially beneficial sexual health programs year colleges wiley periodicals inc
study explored impact psychiatric psychological treatment hostile dominance offenders personality disorder secure psychiatric unit hostile dominance assessed intake repeated six monthly intervals participants reassessment hostile dominance subsequently discharged community association reoffending grave change hostile dominance measured subtracting final hostile dominance score initial score psychopathic traits antisocial personality disorder aspd treatment completion non completion examined results revealed patients completed treatment evidenced reduction hostile dominance whereas patients complete treatment worsened logistic regression analyses showed reduced hostile dominance psychopathy aspd predicted reoffending treatment completion psychopathy checklist factor scores predicted grave reoffending findings supportive potential level hostile dominance reduced completion appropriate treatment changes important reductions reoffending
important part traditional chinese medicine tcm pulse taking profound essence tcm electrical network model cardiovascular system coupled unit left arm simplified model established using simpowersystem components matlab based previous researches analyze correlation pulse wave human cardiovascular physiological pathological adjusting hemodynamic parameters model pulse waveform different pathological period radial artery hypertensive patients outputted thus establishing certain foundation objectifying pulse taking providing reference value
aimto test whether incentive based intervention increased adherence naltrexone also increased opiate abstinence designpost hoc combined analysis three earlier randomized controlled trials showed individually incentives adherence oral extended release injection naltrexone dosing schedules increased naltrexone adherence opiate abstinence settingout patient therapeutic work place baltimore usa participantsone hundred forty unemployed heroin dependent adults participating interventionsparticipants hired model work place weeks randomized contingency prescription group groups offered naltrexone contingency participants required take scheduled doses naltrexone order work earn wages prescription participants could earn wages independent naltrexone adherence measuresthrice weekly monthly urine samples tested opiates cocaine measures naltrexone adherence percentage monthly urine samples positive naltrexone percentage scheduled injections received analyses included pre randomization attendance opiate use cocaine use covariates additional analyses controlled cocaine use naltrexone adherence intervention findingscontingency participants opiate abstinence prescription participants versus opiate negative thrice weekly urine samples respectively versus opiate negative monthly urine samples respectively based initial analyses thrice weekly samples odds ratio confidence interval monthly samples analyses controlled cocaine use thrice weekly samples monthly samples high associated opiate use difference opiate abstinence rates contingency prescription participants reduced controlling naltrexone adherence monthly samples conclusionsincentives naltrexone adherence increase opiate abstinence heroin dependent adults effect appears due increased naltrexone adherence produced incentives
increasing pressures upon automotive industry reduce harmful emissions well meeting key objective enhanced fuel efficiency improving retaining engine output power losses internal combustion engine divided thermal parasitic well due gas leakage untoward compression ring motions frictional losses particularly concern low engine speeds assuming greater share overall losses piston cylinder system accounts nearly half frictional losses loss sealing functionality ring pack also contribute significantly power losses well exacerbating harmful emissions dynamics compression ring inexorably linked tribological performance link made many reported analyses fundamental understanding interplay top compression ring three dimensional elastodynamic behavior sealing function contribution overall frictional losses long overdue paper provides comprehensive integrated transient elastotribodynamic analysis compression ring cylinder liner retaining piston groove lands conjunctions approach hitherto reported literature methodology presented aims aid piston ring design evaluation processes realistic engine running conditions used constitute international drive cycle testing conditions
population managers often deal problems meeting multiple goals example keeping specific levels total population population abundances given stage classes stratified population control engineering set point regulation problems commonly tackled using multi input multi output proportional integral feedback controllers building recent results population management single goals develop control approach context multi objective population management show robust set point regulation achieved using modified controller saturation anti windup elements described paper illustrate theory examples results apply generally linear control systems positive state variables including class infinite dimensional systems thus broader appeal
among many publications environmental life cycle assessment lca transport examples works dedicated means internal transport reason decided gather energy oriented inventory data assess environmental impact related operation selected forklift trucks commonly used means internal transport paper presents main assumptions results relation four phases lca goal scope definition life cycle inventory life cycle impact assessment results interpretation ten forklifts different engines selected order carry life cycle assessment study research based results measuring operating fuel consumption exhaust gas emissions conducted using semtech mobile device pems group devices order make measurements circumstance close real conditions forklift exploitation decided slightly modify operating cycle proposed vdi environmental impact fuel electricity usage exhaust gas emissions assessed using iso guidelines impact method study showed using electric forklift transport payload distance significantly smaller environmental impact using one selected forklifts powered internal combustion engine using forklifts powered liquefied petroleum gas lpg engines leads significantly higher environmental impact whilst use vehicles diesel engines impact level several times lower case drives without load functional unit defined covering distance vehicle load lower impact electric vehicles also obtained analysis includes influences upstream processes fuel electrical energy production even poland production scenario based almost entirely fossil fuels taken consideration electric forklifts still show clear advantage expected technological mix electrical energy production countries higher share renewable nuclear energy taken account environmental indicators electric vehicles would even lower worth noting energy aspects forklift operation analysed studies aiming collect inventory data relating exploitation aspects well production utilization vehicles planned continuation research
quaternion fourier transform qft one key tools studying color image processing indeed deep understanding qft created color images transformed whole rather color separated component addition understanding qft paves way understanding integral transform quaternion fractional fourier transform quaternion linear canonical transform quaternion wigner ville distribution aim paper twofold first provide theoretical background regarding quaternion bound variation function apply derive quaternion fourier linear canonical inversion formulas secondly provide tuition quaternion fourier linear canonical inversion theorems work absolutely integrable function space copyright john wiley sons ltd
prion diseases like alzheimer disease parkinson disease rapidly progressive neurodegenerative disorders caused mis folding followed aggregation accumulation protein deposits neuronal cells measure intramolecular polypeptide backbone reconfiguration way understand molecular basis prion aggregation hypothesis reconfiguration either much faster much slower bimolecular diffusion biomolecular association stable reconfiguration rate becomes similar rate biomolecular diffusion association stable subsequent aggregation faster using technique trp cys contact quenching investigate effects various conditions reconfiguration dynamics syrian hamster rabbit prion proteins protein exhibits behavior three reconfiguration regimes conclude hamster prion prone aggregation reconfiguration rate slow enough expose hydrophobic residues time scale bimolecular association occurs whereas rabbit sequence avoids aggregation reconfiguring times faster hamster sequence
increase device variability performance uncertainty poses daunting challenge analog mixed signal circuit design situation requires robust design approach add large margins circuit system level specification ensure correct operation overall yield paper propose new robust design approach using norm metrics quantify robustness design parameters performance uncertainty addition adopt surrogating procedure achieve robustness design space reduce uncertainty performance space end result proposed method pareto surface provides designer trade offs design robustness performance uncertainty one advantage new approach ability take account strong nonlinear relationship performance design parameters considering set highly nonlinear circuit performances demonstrate effectiveness robust design framework fully cmos operational amplifier circuit elsevier rights reserved
paper fresnel lens based high flux solar simulator hfss developed concentrating solar power research high temperature material testing design commercially available xenon arc lamp coupled silicone glass fresnel lenses optical concentrator lamp lens units distributed circular array total power solar simulator reach kwe ray tracing model developed based real arc emitter shape fresnel lens optics predicting optical performance hfss design testing result shows ray tracing model predict flux distribution focal plane accurately bit conservative center region flux distribution focal plane appears axisymmetric peak flux radiative power total delivered diameter target elsevier ltd rights reserved
green buildings respect nature endeavor mitigate harmful effects environment occupants often interpreted creating sustainable sites consuming less energy water reusing materials providing excellent indoor environmental quality environmentally friendly buildings also consider literally impact birds millions major factor bird collisions buildings choice building materials choices usually made architect may aware issue may looking guidance certification programs leed proof concept educational tool developed software assisted approach characterize whether proposed building design would earn point leed pilot credit avoiding bird collisions using visual programming language dynamo common building information modeling software revit automated assessment designs approach depends parameters incorporate assessments bird threat facade materials analyzes building geometry relative materials processes user input building operation produce assessment
substitution boxes simply boxes used increase confidentiality substitution stage cryptosystem approaches paper efficient method construction box based sine map proposed proposed box able generate random integer sequences highly efficient nonlinearity generated values cryptographic analyses show proposed box method high performance used great potential prominent prevalence designing symmetric cryptosystems copy right protection published elsevier gmbh
examined association nostalgia proneness prejudice four correlational studies assessed nostalgia proneness empathy motivation control prejudiced reactions blatant well subtle prejudice expression prone nostalgia participants likely motivated control prejudice outgroup african americans studies motivation control prejudice mediated relation nostalgia proneness reduced blatant subtle prejudice expression studies finally stronger motivation control prejudice subsequent prejudice expression reduction mediated empathy accompanied higher levels nostalgia proneness studies nostalgia implications intergroup perception specifically prejudicial attitudes elsevier ltd rights reserved
telocytes tcs located ubiquitously internal organs vertebrates heterogeneous recently described cell population stromal space characterized lengthy cytoplasmic extensions reach tens microns called telopodes tps tcs difficult see using conventional microscopes electron microscopy led first identification popescu team first responsible reconstructions indicating tcs organization three dimensional network believed accountable complex roles tcs gradually became increasingly evident tcs difficult characterize terms immunophenotype phenotype different depending location needs tissue one time review discusses growing body evidence accumulated since tcs discovered highlights complex interplay tcs stem cells might importance tissue engineering regenerative medicine elsevier ltd rights reserved
type diabetes tdm considered associated higher likelihood hearing impairment however molecular mechanisms underlying association diabetes poorly understood micrornas recently demonstrated closely associated hearing loss considered promising therapeutic targets herein investigated whether mir contributes diabetes related cochlear hair cell apoptosis sought identify underlying mechanism results showed mir regulated cochleas mice accompanied significant hearing threshold elevation hair cell loss however expression sirt significantly regulated hypoxia inducible factor alpha hif alpha levels dramatically increased cochleas mice addition high glucose cultured house ear institute organ corti hei cell line mir overexpression inhibited sirtuin sirt expression increased hif levels promoted apoptosis mir knockdown exerted effects diametrically opposed observed overexpression interestingly hif knockdown almost eliminated cell apoptosis induced high glucose levels also examined modulation hif alpha expression sirt results showed sirt knockdown promoted high glucose induced hif alpha expression sirt overexpression significantly inhibited hif alpha level induced high glucose findings point new mechanism mir exerts detrimental effects negatively regulating sirt hif alpha signaling provide new therapeutic targets treating hearing impairment diabetes elsevier inc rights reserved
sleep learning promotes quantitative strengthening new memories less known impact sleep qualitative reorganisation memory focus review studies shown declarative system sleep facilitates abstraction rules schema formation integration knowledge existing schemas schema integration creativity requires disbandment existing patterns schema disintegration schema formation integration might primarily benefit slow wave sleep whereas disintegration schema might facilitated rapid eye movement sleep procedural system sleep fosters reorganisation motor memory neural mechanisms processes remain determined notably emotions shown modulate sleep related reorganisation memories final section review propose sleep related reorganisation memories might particularly relevant mental disorders thus sleep disruptions might contribute disturbed memory reorganisation development mental disorders therefore sleep related interventions might modulate reorganisation memories provide new inroads treatment elsevier ltd rights reserved
purpose review incorporation patients perspective clinical research critical ensure outcomes measured reflect matter patients review summarizes recent efforts include patients perspective development outcome measures importance encouraging patient participation decision making self management recent findings since inclusion fatigue patient endorsed core outcome measure rheumatoid arthritis trials omeract instrumental advocating patient involvement development core domains instruments current endeavors include cultivating understanding remission eyes patients gaining sense measure features pain stiffness deemed important patients concept remission explored patients highlighting common goal returning normality additionally various tools developed assess unmet needs rheumatology patients advances also made development revision patient centered core measures rheumatologic diagnoses outside summary incorporating patients perspective considered essential feature outcomes research future research focus best involve patients specific research activities
paper try present problems modern approach treating various phobias virtual environments created virtual reality tools help make treatment certain types phobias efficient attention form phobia treatment help rise world also monitoring development well paper introduces necessary hardware software piloted department also methods creating virtual environments models application designed medical therapies patients work searched tested following methods creating virtual environments modelling using computer graphics modelling animation using animation programs taking pictures static objects scenes filming moving objects scenes using classic video special scanning techniques create degrees panoramas combination methods
flight control insects heavily dependent vision thus dim light decreased reliability visual signal detection also prompts consequences insect flight emerging understanding neural mechanisms different species employ adapt visual system low light however much less explored comparative analyses low light affects flight behaviour insect species corresponding links physiological adaptations behaviour investigated whether flower tracking behaviour three hawkmoth species different diel activity patterns revealed luminance dependent adaptations using system identification approach found clear luminance dependent differences flower tracking three species explained simple luminance dependent delay model generalized across species discuss physiological anatomical explanations variance tracking responses could explained simple models differences species could explained simple delay model however several cases could explained addition second model parameter simple scaling term captures responsiveness species flower movements thus demonstrate much variance luminance dependent flower tracking responses hawkmoths different diel activity patterns captured simple models neural processing article part themed issue vision dim light
paper presents fundamental study flow dynamics heat transfer induced slug flow saturated flow boiling circular microchannel numerical simulations carried utilizing commercial cfd solver ansys fluent built volume fluid vof method advect interface improved implementing self developed functions model phase change surface tension force continuous stream bubbles generated additional user defined functions patching vapor bubbles channel upstream constant generation frequency modeling framework capture essential features heat transfer slug flows continuous stream bubbles investigated detail mutual influence among growing bubbles fluid mechanics liquid slug trapped two consecutive bubbles effect bubble acceleration thickness thin liquid film trapped channel wall bubbles transient growth heat transfer coefficient periodic variation terminal steady periodic regime reached transit bubble liquid slug pairs furthermore results continuous stream bubbles found quite different single bubble emphasizing importance modeling multiple bubbles study process finally outcomes analysis utilized advance theoretical model heat transfer microchannel slug flow best reproduces present simulation data
blood coagulation essential hemostasis however excessive coagulation lead thrombosis factor xii starts intrinsic coagulation pathway contact induced factor xii activation provides mechanistic basis diagnostic aptt clotting assay despite function fibrin formation test tubes patients animals lacking factor xii completely normal hemostasis lack bleeding tendency observed factor xii deficiency states sharp contrast deficiencies components coagulation cascade factor xii considered function coagulation vivo recently experimental animal models showed factor xii activated inorganic polymer polyphosphate released procoagulant platelets polyphosphate driven factor xii activation essential role pathologic thrombus formation cumulatively data suggest target polyphosphate factor xii activated form factor anticoagulation factor xii pathway specifically contributes thrombosis hemostasis interference pathway provides unique opportunity safe anticoagulation associated excess bleeding review summarizes current knowledge factor xii functions activators inhibitors
article shows two dimensional analysis model predicting eddy current loss winding flux switching permanent magnet open circuit finite element method used electrical machine design however numerical method always time consuming depending geometry mesh quality finite element method high thus finite element method time consuming special electrical machines solve problem sub domain model using fourier analysis improved flux switching permanent magnet machine obtained solving poisson laplace equations polar coordinates domain magnet air gap rotor stator slots well external region model accounts influence interaction stator slots air gap well rotor slots air gap magnetic field distribution flux linkage back electromotive force cogging torque eddy current loss waveforms derived analytical method verified finite element analysis best knowledge authors analysis carried previously
emerging change across science technology engineering mathematics curriculum implementation online virtual laboratories supplements replacements homework assignments laboratory exercises test effectiveness labs web based virtual laboratory topic torsion engineered biological materials developed lab contains extensive data sets videos experiments narrated presentations lab practice theory assignments flexibility use built lab providing capability web pages tailored needs particular institution lab implemented evaluated standard sophomore level statics strength materials course results evaluation show virtual lab clear helped students understanding torsion concepts offered number benefits however students also rated hands labs fun interesting wiley periodicals inc
people highly visible may perceived also important influential good bad moods influence extent people rely irrelevant visual fluency cues forming impressions based recent work affect cognition two experiments predicted found positive affect increased negative affect eliminated effects visual fluency impressions experiment autobiographical mood induction participants read two people whose visual fluency factorially manipulated changing size color photos mood visual fluency influenced impressions significant mood visibility interaction positive affect increased negative affect eliminated effects visual fluency experiment replicated results different mood induction also found mood induced differences information processing style mediated effects relevance findings impression formation everyday situations considered implications recent affect cognition theories discussed elsevier inc rights reserved
lightweight cipher designs try minimize implementation complexity cipher maintaining specified security level using small number gates lowers implementation costs enables easier protections side channel attacks paper study connection number gates multiplicative complexity complexity algebraic attacks model encryption multiple right hand sides mrhs equations resulting equation system transformed syndrome decoding problem complexity decoding problem depends number gates relative number known output bits respect number unknown key bits allows apply results coding theory explicitly connect complexity algebraic cryptanalysis multiplicative complexity cipher means provide asymptotic upper bounds complexity algebraic attacks selected families ciphers based hardness decoding problem
context many researchers argued providing interoperability support considering format meaning syntax semantic data exchange enough achieve complete effective meaningful collaboration pragmatic interoperability highlighted key requirement enhance collaboration however fulfilling requirement trivial task lack works discussing solutions achieve level interoperability objectives aim study present systematic review mapping literature order identify analyse classify published solutions achieve pragmatic interoperability method conduct systematic review mapping accordance guidelines proposed evidence based software engineering literature results study identified papers reporting pragmatic interoperability computational solutions first paper set selected papers published main strategies used address pragmatic interoperability issues service discovery composition selection ontologies application domain identified solutions mainly business addition identified solutions software architectures conclusion mature proposals addressing pragmatic interoperability still rare literature although many works discussed importance pragmatic interoperability necessary researchers report solutions implement evaluate pragmatic interoperability order make progress area elsevier rights reserved
accessible summary known subject concept compassion well documented healthcare literature received limited attention mental health nursing paper adds existing knowledge mental health nurses struggle defining compassion study limitations brings greater clarity meaning compassion community mental health nurses nhs organizations mental health nurses need time reflect provision compassionate care implications practice study shown compassion important nhs healthcare management frontline mental health nurses policy makers potential sharing practice vision across nhs organisations mental health nurses could benefit training facilitate understanding compassionate practices emphasis placed importance self compassion nurtured secure base clinical supervision abstract introduction increasing emphasis policy research practice internationally importance caring health care compassion needs core healthcare professionals practice recently health care received negative attention media government reports cite lack compassion care rationale concept compassion received limited attention community mental health nursing aim based data taken semi structured interviews community mental health nurses paper aims describe interpretations perspectives compassion gain insight development meaning method naturalistic interpretive approach taken study semi structured interviews nine mental health nurses analysed using burnard step model thematic analysis findings research illuminates complexity compassion practice impacts emotional responses relationships self patients colleagues employing organization participants identified difficulties engaging compassionate practice whilst recognizing driving force underpinning provision care implications practice mental health nurses need supported work towards greater understanding compassionate care clinical practice need self compassion
paper presents closed loop interface micro machined accelerometer sensor based force feedback sigma delta loop high order closed loop accelerometer interface circuit investigated time shared multiplexing electrostatic feedback technique used eliminate feedthrough feedback signals pick charge signals low noise capacitance detection circuit proposed correlated double sampling technique eliminate noise offset operational amplifier interface fabricated standard cmos process active circuit area chip consumes supply sampling clock khz average noise floor digital accelerometer dbv khz bandwidth corresponding sensitivity measured resolution accelerometer system nonlinearity figure merit shows proposed sigma delta interface achieves good performance
subset construction classical algorithm determinization nondeterministic finite automaton nfa equivalent deterministic one dfa although works fine application domains may inappropriate nfa expands time determinization required expansion diagnosis active systems artificial intelligence model based testing software engineering expanding automaton idea algorithm incremental determinization expanding automata may suitable given nfa equivalent dfa expansion delta determinization boolean delta performed based also delta rather starting scratch generation dfa equivalent idea applies set actions sufficient transforming way possibly large part determinization process avoided experiments show degree convenience determinizing expanding automata using idea rather largely depends nature expanding automaton actual application domain
representing test sample linear combination training samples sparse representation based classification src shown promising performance many applications computer vision signal processing however several shortcomings src norm employed src measure reconstruction fidelity noise sensitive norm induced sparsity consider correlation among training samples furthermore real applications face images similar variations illumination expression often higher correlation subject therefore correspondingly propose improve performance src two aspects replacing noise sensitive norm estimator enhance robustness emphasizing sparsity terms number classes instead number training samples leads structured sparsity formulated robust structured sparse representation rgsr model efficiently optimized via alternating minimization method half quadratic optimization framework extensive experiments representative face data sets show rgsr achieve competitive performance face recognition outperforms several state art methods dealing various types noise corruption occlusion disguise
research shown gender role prescriptions bias reactions men women work behaviors current work draws upon idea extends consider violations procedural interactional justice rules results four experimental studies demonstrate men women receive differential performance evaluation ratings reward recommendations violate organizational justice rules coincide content prescriptive gender stereotypes specifically women rated less favorably men exhibited interactional injustice study study engaged procedural injustice study findings also indicate interactional justice violations impolite caring well subordinates procedural justice violations deemed less acceptable female managers male managers study overall findings suggest reactions injustice influenced expectations men women behave
paper presents new technology polish market bim nowadays method project management construction change many decades traditionally information handed form flat drawings sketches graphics technical drawings nowadays program generated visualizations documentation form involved always two dimensional last years new conception raised base changing technology design bim building information modeling one latest important technologies architecture civil engineering construction management information handed form three dimensional model consists separated models characterized parameters mass length layer level phase construction process element used produced words ideal illustration components built building way reliable virtual copy building created authors published elsevier ltd
aim study assess amount per use cosmetic products consumed home adult child baby french population men women participated study performed four cities france enquiry performed cosmetics including general hygiene skin care hair care hair styling make fragrances solar shaving depilatory baby products coupled frequency data previously obtained ficheux amounts per use data used order assess exposure cosmetics french population current exposure values could useful safety assessors safety agencies elsevier ltd rights reserved
gastrointestinal disease common among hiv infected individuals prevalence distribution ano rectal pathology well studied setting objective study therefore determine prevalence determinants ano rectal pathology hiv infected patients attending douala general hospital hiv treatment centre hospital based cross sectional study undertaken collected socio demographic clinical laboratory data using structured questionnaire patients files study participant full physical ano rectal examination studied factors associated least one ano rectal lesion logistic regression reporting odds ratios ors confidence intervals included hiv infected patients mean age years men median duration since hiv diagnosis interquartile range years median cell count interquartile range cells prevalence ano rectal pathology hemorrhoids proctitis common lesions found patients multivariate logistic regression factors associated ano rectal pathology cells highly active antiretroviral therapy inpatient ano rectal intercourse one sexual partner ano rectal pathology common amongst hiv infected patients care givers actively investigate treat improve quality life people living hiv aids
amygdala attracted considerable research interest potential involvement various neuropsychiatric disorders recently attempts made using magnetic resonance imaging mri evaluate integrity axonal connections amygdala pathological conditions although amygdalar pathways studied extensively animal models anatomical references human brain limited histology based resources small number slice locations orientations annotations present study performed high resolution mri postmortem human brains followed serial histology sectioning histology data used identify amygdalar pathways anatomical delineation assigned structures extended using mri data able define detailed anatomy stria terminalis amygdalofugal pathway well anatomy nearby basal forebrain areas including substantia innominata present results help understand detail white matter structures associated amygdala serve anatomical reference design vivo mri studies interpretation data
central china power grid ccpg north china power grid ncpg connected together single ultra high voltage uhv transmission link suffering power disturbances power oscillation high magnitude long period would happen uhv tie line may affect synchronous stable operation interconnected two power grids study proposes novel emergency control scheme high voltage direct current hvdc ccpg suppress high peak value power oscillation based two machine equivalent model maximum rising slope power oscillat ion used predict peak value power oscillation power disturbance used reference emergency power modulation simulation verification carried based full model ccpg ncpg using power system analysis software package moreover field test also carried ccpg simulation results recorded wave curve show proposed hvdc emergency control scheme effectively suppress peak value different power disturbances significantly improves transient performance interconnected power system power transfer capacity uhv tie line
due existence complexities heterogeneities hierarchy discreteness interactions municipal solid waste management mswm systems beijing china series socio economic eco environmental problems may emerge worsen result irredeemable damages following decades meanwhile existing studies especially ones focusing mswm beijing could hardly reflect complexities system simulations provide reliable decision support management practices thus framework distributed mixed integer fuzzy hierarchical programming dmifhp developed study mswm complexities beijing selected representative case beijing mswm system comprehensively analyzed many aspects socio economic conditions natural conditions spatial heterogeneities treatment facilities system complexities building solid foundation system simulation optimization correspondingly mswmsystem beijing discretized grids reflect spatial heterogeneity dmifhp model nonlinear programming problem constructed parameterize beijing mswm system enable scientific solving solution algorithm proposed based coupling fuzzy programming mixed integer linear programming innovations advantages dmifhp framework discussed optimal mswm schemes mechanism revelations discussed another companion paper due length limitation
symbolic analysis powerful tool accelerates electronic design process providing insight behavior circuit recently analysis synthesis electronic circuits nullors received considerable attention due fact nullors flexible versatile active elements efficient analysis methods nodal analysis coates flow graphs two graphs proposed literature widely used arguably reported generate vanishing terms symbolic network functions last cited analysis method may considered promising actually using two graph method symbolic transfer functions calculated via either signal flow graphs mason formula without restriction type sources dependent independent spanning tree enumeration method rlc circuits nullor equivalent circuits independent voltage sources types controlled sources paper propose new method symbolic analysis circuits nullors using two graph method versions signal flow graphs enumeration spanning trees new method helps see distinctly relationships various circuit components method using signal flow graph enables calculate symbolic network functions without excess terms method using enumeration spanning trees
although printing additive manufacturing holds great promise direct manufacturing technology geometric accuracy built products remains critical issue especially freeform products complex geometric shapes efforts long attempted improve accuracy built freeform products lack generic prescriptive methodology transparent specific designs processes paper fills gap establishing methodology predict compensate plane plane geometric deformation built freeform products based limited number simple trial shapes built upon previous predictive model optimal compensation study cylinder polyhedron shapes paper makes breakthrough directly controlling arbitrary freeform shape deformation computer aided design experimental investigation using stereolithography process successfully validates proposed prescriptive modeling compensation methodology paper provides prospect proactively improving printing accuracy arbitrary products built variety processes note practitioners additive manufacturing characteristics extremely high product varieties low product volumes achieving high consistent geometric accuracy therefore daunting task new products may tried especially fabrication products complex arbitrary shapes paper presents novel prescriptive methodology predict control product plane geometric errors based limited number trial cases successful experimental validation indicates prospect direct digital manufacturing arbitrary freeform products improved precision
approximately hiv seropositive individuals develop hiv associated neurocognitive disorders hand commonly include alterations executive functions inhibition set shifting complex problem solving executive function deficits hiv fairly well characterized however relatively studies explored elemental dimensions neurocognitive impairment hiv deficits temporal processing caused hiv may underlie symptoms impairment higher level cognitive processes translational measures temporal processing including cross modal prepulse inhibition ppi gap prepulse inhibition gap ppi gap threshold detection studied mature ovariectomized female hiv transgenic rats express hiv genes constitutively throughout development cross modal ppi revealed relative insensitivity manipulation interstimulus interval isi hiv animals comparison control animals extending previously reported temporal processing deficits hiv rats advanced age suggesting permanence temporal processing deficits gap ppi hiv animals exhibited relative insensitivity manipulation isi comparison control animals gap threshold detection hiv animals displayed profound differential sensitivity manipulation gap duration presence hiv transgene diagnosed accuracy using gap threshold detection measures understanding generality permanence temporal processing deficits hiv rat vital modeling neurocognitive deficits observed hand provides key target development diagnostic screening tool
losing spouse among devastating events may occur people lives use longitudinal data participants german socio economic panel study soep examine life satisfaction changes experience spousal loss whether socio demographic factors social health resources moderate spousal loss related changes life satisfaction whether extent anticipation reaction adaptation spousal loss associated mortality results reveal life satisfaction shows anticipatory declines two half years prior anticipation steep declines months surrounding reaction lower levels spousal loss adaptation older age associated steeper anticipatory declines less steep reactive declines additionally younger age better health social participation poorer partner health associated better adaptation higher pre loss life satisfaction less steep reactive declines better adaptation associated longevity discussion focuses utility examining interrelatedness among anticipation reaction adaptation understanding change life satisfaction context major life events
aims tricuspid regurgitation patients mitral valve disease associated poor outcome mortality limited data impact functional outcome survival patients undergoing mitraclip procedures available methods results patients mean age euroscore symptomatic mitral regurgitation functional undergoing mitraclip procedure included followed days baseline presented grade grade grade iii grade dividing groups according baseline grades follow nyha class significantly improved patients trii compared patients trii multivariate cox regression revealed strongest independent predictor mortality hazard ratio conclusions concomitant baseline negatively influences functional outcome mortality patients undergoing mitraclip procedures results underline need dedicated interventional strategies treatment patients symptomatic
objective frequent demands others relationships associated worse physiological health outcomes present research investigated potential moderators relationship frequency demands one family inflammatory profiles among adolescents closeness adolescents relationships families frequency adolescents provided help families method two hundred thirty four adolescents ages age male completed daily dairy reported frequency demands made family members also interviewed closeness family relationships reported daily diary frequently provided help families adolescents also underwent blood draw assess low grade inflammation proinflammatory cytokine production response bacterial stimulation results frequent demands family predicted higher levels low grade inflammation cytokine production response bacterial stimulation adolescents family closeness moderated relationship frequent demands stimulated cytokine production frequent demands predicted higher cytokine production among adolescents closer families furthermore frequency providing help moderated relationship frequent demands low grade inflammation stimulated cytokine production frequent demands predicted worse inflammatory profiles among adolescents provided help families conclusions findings build previous work family demands health show circumstances family demands might physiological cost
background chronic rhinosinusitis crs heterogeneous disease characterized persistent sinonasal inflammation sinus microbiome dysbiosis basis heterogeneity poorly understood sought address hypothesis limited number compositionally distinct pathogenic bacterial microbiota exist crs patients invoke discrete immune responses clinical phenotypes crs patients results sinus brushings patients crs healthy individuals collected endoscopic sinus surgery analyzed using rrna gene sequencing predicted metagenomics rna profiling mucosal immune response show crs patients cluster distinct sub groups dsi iii defined specific pattern bacterial colonization permutational multivariate analysis variance permanova sub group typically dominated pathogenic family streptococcaceae dsi pseudomonadaceae dsii corynebacteriaceae dsiii staphylococcaceae dsiii pathogenic microbiota predicted functionally distinct permanova encode uniquely enriched gene pathways including ansamycin biosynthesis dsi tryptophan metabolism dsii two component response dsiii ppar gamma signaling pathway dsiii also associated significantly distinct host immune responses dsi iii invoked variety pro inflammatory responses dsiii exhibited significantly increased incidence nasal polyps fisher exact relative risk primarily induced expression kruskal wallis conclusions large proportion crs patient heterogeneity may explained composition sinus bacterial microbiota related host immune response features may inform strategies tailored therapy patient population
argued children possess advanced theory mind tom likely act prosocially yet empirical findings mixed address issue definitively meta analytic integration prior literature met appropriate inclusion criteria conducted total studies including children years age contributed analyses collapsed across studies significant association emerged indicating children higher tom scores also received higher scores concurrent measures prosocial behavior magnitude effect similar across tom assessments requiring identification others cognitions versus emotions existed irrespective whether tom measure imposed demands false belief reasoning association tom also evident different subtypes prosocial behavior helping cooperating comforting tom similar effect boys girls slightly stronger children aged years older relative younger peers taken together findings provide strongest evidence date able explicitly consider people thinking feeling related children tendencies act prosocially although magnitude association relatively weak
paper describes dynamic energy modeling activity performed achieve nzeb time net nearly zero energy building starting early design stage construction management modeling tool ieshas used assist strategy planner definition sustainability targets specialists detailed design hvac system glazed facade lighting equipment energy model updated every variation occurred construction phase results dynamic simulation checked guarantee energy performances forecasted paper emphasizes choices taken energy model build peculiar focus simplifications applied also interactions different assessment tools discussed authors published elsevier ltd
hydroxypropyl methacrylamide hpma copolymers previously found represent versatile delivery platform early detection intervention orthopedic implant loosening article evaluated impact different structural parameters hpma copolymeric system molecular weight drug content pharmacokinetics biodistribution profile using alexa fluor irdye labeled hpma copolymer dexamethasone dex conjugates different dexamethasone dex contents found predominant impact factor profiles dex dex content secondary impact factor gamma counter based studies increased dex reduced elimination leading lower clearance longer half life higher systemic exposure auc mrt semiquantitative live animal optical imaging evaluation distribution dex peri implant inflammatory lesion increased increased result confirmed facs analyses cells isolated peri implant regions systemic administration alexa fluor labeled dex since vitro cell culture study suggested internalization dex macrophages generally independent dexs dex content impact dex content profile likely exerted physiological pathophysiological levels rather cellular level gamma counter based analyses semiquantitative optical imaging analyses dex dex content showed fast clearance dynamic light scattering analyses unexpectedly revealed significant molecular aggregation dex dex content level underlining mechanisms aggregation fast vivo clearance dex warrant investigation
purpose study describe level integration community health workers chws missouri public healthcare systems using cross sectional survey research design representatives missouri local public health agencies rural health clinics federally qualified health centers pre contacted telephone provide electronic mail knowledgeable person facility location complete brief electronic survey use chws representatives response rate contacted health systems completed profile community health workers missouri health systems assess role professional development information needs chws used key informants agencies abridged survey created participants responded survey indicated chws currently working organization descriptive statistics measures central tendency computed participants noted chws employed organizations chws connected people services served low income rural populations addressed heart disease issues participants currently employ chws indicated anticipate needing near future utilizing chws perceived chws vital role healthcare securing sustainable funding chws challenging utilization chws missouri healthcare systems limited role missouri healthcare systems expand campaign educate role value needed
aims incontinence associated dermatitis iad resulting diarrhoea faecal incontinence common problem intensive care occurring patients estimated million dollars spent annually continence skin care project aimed evaluate improve staff knowledge iad also improve practice identification prevention treatment iad icu methods pre post audit framework used implement best practice recommendations august march nursing staff surveyed chart review conducted audit baselines knowledge nursing practice regarding iad education product standardization used implement best practice recommendations post audit conducted evaluate changes knowledge practice results thirty one pre implementation post implementation nurses surveyed evaluate knowledge iad identification care documentation practices iad policy iad specific skin assessment tool use existed icu implementation increase ability staff distinguish iad pressure injuries increase use skin protectant improvement correct application skin protectants encouraging nurses using single standard skin protectant implementation opposed audit nurses using multiple products implementation increase staff surveyed post audit said reported perineal skin patients iad however iad documentation audit audit evidenced chart review remained poor conclusion project created awareness iad icu clear knowledge improvement nursing staff able differentiate iad pressure injuries skin cleansing protection regime clear consistent single standardized product used prevent treat iad small improvement consistently documenting condition perineal skin patients iad however beyond scope project develop policy implement iad specific skin assessment tool icu would improved documentation iad icu
prevention sexually transmitted infections stis important part care hiv infected individual stis associated increased risk transmission acquisition hiv among hiv infected persons treatment failures high recurrence rates stis common despite recognized importance prevention discussion sexual health rates screening stis suboptimal moreover rates stis syphilis continue increase particularly men sex men msm review focuses common stis seen among hiv infected individuals recommendations screening prevention
background objectives despite recognised disparities child health outcomes associated sleep majority research based small homogeneous samples using nationally representative sample children adolescents examined trends social determinants inadequate sleep across age groups study design comparison cross sectional studies methods study used waves national survey children health nationally representative survey year olds parents reported whether child inadequate sleep days getting enough sleep days results inadequate sleep increased among year olds among year olds among year olds among year olds households high school degree likely inadequate sleep adjusted ors although year olds gradient inadequate sleep across income aors year olds two highest income levels likely inadequate sleep aors parents reports neighbours watch children associated increased risk inadequate sleep across ages aors conclusions inadequate sleep occurred young age six years increased age became prevalent socially patterned order prevent inadequate sleep across life course surveillance monitoring needed across age groups identify critical periods intervention royal society public health published elsevier ltd rights reserved
purpose purpose paper investigate impact dual medium content context one offered online twitter communication medium context reporting elite sports content context traditional conceptualizations genderlect design methodology approach quantitative content analysis coding variety traditional gendered language markers conducted tweets male female reporters covered men women ncaa final four basketball tournaments findings consistent tenets social role theory duel medium content context twitter sports produces several language patterns frustrate attempts categorize language markers according traditional conceptualizations genderlect thus provides support redefinition genderlect research limitations implications paper findings suggest people adapt communication patterns match context communicate whether adaptation takes place conscious effort natural byproduct moving one context another remains discovered advice female sports journalists vigilant unwittingly undermining credibility perceived expertise offered inquiry allows researchers study sociology sport practical implications paper demonstrates online environments allow traditional gender roles expectations challenged broken genderlect features appear tenacious could undermine attempts break gender barriers social implications sport mirrors society communication adaptations appear online environmental context reporters tweets sport appear societal contexts originality value studies investigated differences reporting gender fewer investigated differences sports reporting gender fewer investigated differences sports reporting gender twitter
objectivethere evidence people eating disorders display altered intertemporal choice behavior degree preference immediate rewards delayed rewards compared healthy controls individuals anorexia nervosa binge eating disorder show decreased increased rates temporal discounting devaluation delayed rewards respectively first study investigate people bulimia nervosa methodthirty nine individuals men men completed hypothetical monetary task binary choices participants chose whether would prefer receive smaller amount money available immediately larger amount available months self reported ability delay gratification behavioral opposite also measured resultsindividuals showed greater preference smaller sooner rewards decreased self reported capacity delay gratification relative experimental groups differ age gender ratio bmi discussionincreased rates may contribute core symptoms appear involve making choices immediate delayed rewards binge eating compensatory behaviors altered intertemporal choice behavior could therefore relevant target intervention patient group wiley periodicals inc int eat disord
development validation surface suspended sediment concentration ssc models derived surface remote sensing reflectance spectra lambda important satellite monitoring estuarine coastal waters seven empirical seven semianalytical spectral reflectance models evaluation surface ssc compared one another laboratory tank one dataset situ measurements two datasets performed different natural waters east china models presented form spectral ratios wavelengths selected list nasa satellite sensor modis unsaturated central wavelengths statistical analysis performed find best models spectral ratios remote sensing monitoring purposes analysis shown empirical models generally superior semianalytical models solution existence prediction accuracy correlation observed ssc values however semianalytical models using red green spectral ratio demonstrated approximately accuracy correlation empirical models provides additional support using simple easily calculated empirical models additionally relationships ssc inherent optical properties iops absorption backscattering coefficients iops lambda provided semianalytical models benefits aquatic optics remote sensing purposes
linear mixed model added integrated ornstein uhlenbeck iou process linear mixed iou model allows serial correlation estimation degree derivative tracking rarely used partly due lack available software implemented linear mixed iou model stata using simulations assessed feasibility fitting model restricted maximum likelihood applied balanced unbalanced data compared different optimization algorithms parameterizations iou process data structures randomeffects structures fitting model practical feasible applied large moderately sized balanced datasets observations large unbalanced datasets non informative dropout intermittent missingness analysis real dataset showed linear mixed iou model better fit data standard linear mixed model independent within subject errors constant variance
specific objective exploring surface pressure characteristics revealing torsional vortex induced vibration viv mechanisms bridge deck particular geometry numerous simultaneous pressure measurement campaigns performed wind tunnel aerodynamic countermeasure modified unmodified sections section model different angles incidence conditions smooth turbulent flow mean fluctuating pressure distributions instantaneous pressures typical instants dominant pressure frequencies pressure phase differences dominant frequency individual pressure measurement taps correlation coefficients among local global torsional moments studied revealing origins mechanisms torsional vivs results demonstrate angle incidence flow conditions smooth turbulent installation spoiler exert significant effects surface pressure distributions hence affecting corresponding aerodynamic performance bridge deck turbulence top surface potentially neutralize vortex shedding effects enhance immunity torsional vivs signature turbulence leading fairing edge effectively weakened even destroyed sufficiently intense oncoming turbulence turbulence generated spoiler appropriate configuration location therefore potential torsional vivs could suppressed interaction vortices generated oncoming signature turbulences knowledge essential thorough evaluation potential torsional vivs particular bridge deck
beta amyloid deposition brain accumulates function age people syndrome subsequent development alzheimer disease neuropathology typically years age vivo imaging using pittsburgh compound pib ligand facilitated studies linking cognition dementia however studies pib binding across lifespan current study describes vitro pib binding frontal cortex autopsy cases compared non controls tissue cases included controls pib binding significantly associated age age years pib binding rose dramatically along increasing individual variability pib binding correlated amount beta using fixed frontal tissue fluorescent pib neuritic cored plaques along extensive cerebral amyloid angiopathy showed pib binding results suggest cortical pib binding shown positron emission tomography imaging reflects plaques cerebral amyloid angiopathy brain elsevier inc rights reserved
follow studies exist minors commit sexual homicides adjust released back community important question given extreme nature crimes lack recidivism data expectation one half freed prison mid life likewise studies exist role culture pervasive media violence plays offenses report describes year old boy committed witnessed media violence inspired sexual homicide follow information provided community adjustment adult four years release prison multiple indicators brain dysfunction watched slasher film committing blitz style crime upon female neighbor media violence literature reviewed backdrop developmental abnormalities neuropsychiatric vulnerabilities family dysfunction mental illness case illustrates confluence variables combined tinder erotic screen violence may lead sexual murder
veterans report lower health related quality life hrqol relative general population identifying behavioral factors related hrqol malleable change may inform interventions improve well vulnerable group current study sought characterize hrqol largely male sample veterans addictions treatment relation norms association five recommended health behavior practices regularly exercising managing stress good sleep hygiene consuming fruits vegetables tobacco free assessed hrqol veterans addictions treatment male mean age range using scales four validated measures data reduction methods identified two principal components reflecting physical mental hrqol model testing hrqol associations health behaviors adjusted relevant demographic treatment related covariates compared norms sample lower hrqol scores better psychological hrqol associated higher subjective social standing absence pain trauma lower alcohol severity monotonically sum health behaviors variance hrqol exercise sleep hygiene stress management strongly associated hrqol among veterans addictions treatment future research needed test effect interventions improving well high risk group
pomegranate fruit extract rich polyphenols shown exert chondroprotective effects mechanism established used vitro model inflammation osteoarthritis investigate potential suppress interleukin beta stimulated expression inflammatory cytokine generation reactive oxygen species ros levels investigated mechanism inhibition analyzing activation kinases upstream primary human chondrocytes total phosphorylated forms kinases expression determined protein mrna levels western immunoblotting taqman assay respectively dihydrorhodamine staining estimated ros generation pomegranate fruit extract inhibited mrna protein expression generation ros inhibited mediated phosphorylation inhibitor nuclear factor kappa kinase subunit beta ikk expression ikk mrna degradation activation nuclear translocation human chondrocytes importantly phosphorylation inducing kinase blocked treated human chondrocytes taken together data suggest exerts chondroprotective effect suppressing production ros levels inhibition activation blocked via modulation activation upstream kinases human chondrocytes copyright john wiley sons ltd
bigels biphasic systems produced organogel oleogel hydrogel mixed together high shear rates systems promising different uses among formulation new cosmetic matrices cosmetic agents delivery investigation present paper common cosmetic formulation skin care enriched increasing fractions monoglycerides fatty acids olive oil orginogels order understand rheology microstructure systems small amplitude oscillation tests nmr self diffusion analysis contrast phase microscopy electric conductivity confirmed addition organogel caused microstructural change starting material turned complex system probably matrix matrix structure present highest fractions added organogel elsevier inc rights reserved
paper aims defining methodology evaluate lightning performance system overhead distribution lines well known evaluation lightning performance relies generally monte carlo approach generates many different lightning events calculates corresponding voltages perform calculation power system computer aided design pscad module developed companion paper adopted however call pscad implies non negligible computational effort efficient approach presented order limit number simulations much possible obtained results compared ones provided available techniques simple structures order highlight main features method typical italian distribution network segment comparative analysis shows good agreement methods effectiveness proposed technique terms computational effort reduction
study focuses development evaluation portable electronic nose nose system identification different types saffron stigma crocus sativus iridaceae based volatile organic compounds vocs system utilizes metal oxide semiconductor gas sensors direct head space sampling real time data acquisition system microcontroller devices laptop computer along multivariate computational tools used development expert system eleven saffron samples different regions prepared experiments principal component analysis pca hierarchical clustering analysis hca unsupervised models multilayer perceptron mlp neural networks partial least squares pls supervised models utilized develop nose discrimination capability based results pca volatile compounds fingerprints revealed eleven distinct groups corresponding eleven different saffron samples confirmed hca classified groups five distinct quality classes qcs excellent good good medium poor quality used mlp pls classification goals results analysis showed performance mlp model prediction saffron samples better pls model success rate high correlation coefficients cross validation relatively low rmse value results show developed system capable discriminating saffron samples based aroma utilized aroma quality control system published elsevier
background objective study overview attempts suicide young females relation pcos thyroid profile dysfunction world health report puts yearly global prevalence suicide attempt varies incidence attempted suicide greatly influenced differences age sex race religion culture marital status habitat climate social systems study aimed analyse risk factor mode attempt spectrum association pcos thyroid dysfunction young females materials methods present study conducted department medicine history attempted suicides march may cases female years subjects meeting selection criteria evaluated results total female patients admitted emergency ward tertiary care centre study period one half years march till may study period patients attempt suicide admitted medical icu tertiary care centre studied resulted prevalence incidence attempt suicides cases poisoning unmarried married females rest hanging evaluation hospitalised patients due suicidal attempt showed pcos cases hypothyroidism hyperthyroidism cases respectively among cases hypothyroidism signs depression present cases whereas cases stress signs frustration anxiety stress depression present cases respectively among diagnosed pcos overall cases stress led suicidal attempt conclusion present study revealed importance hormonal changes occur pcos hypothyroidism causes psychophysical changes young reproductively active females attempt made focus issues future intervene early prevent complications
detection chemical agents different environments combination plastic optical fibers pofs molecularly imprinted polymers mips receptors tested way obtain low cost highly selective sensitive optical chemical sensors based plasmonic resonance work novel type optical chemical sensor able detect binding reactions occurring mip analyte designed fabricated applied selective detection dibenzyl disulfide dbds transformer oil analyte important control transformer oil since responsible corrosive properties oil new optical sensor platform based two plastic optical fibers work segmented waveguides coupled polymer molecularly imprinted analyte prepolymeric mip solution deposited drop coating trench milled two fibers experimental results indicated new sensor useful determination dbds transformer oil paves way new approach optical fiber sensors mips elsevier rights reserved
paper presents halftoning based watermarking method enables embedding color image binary black white images maintain quality halftone images method maps watermarks halftone channels using homogeneous dot patterns patterns use different binary texture arrangement embed watermark prevent degradation host image maximization problem solved reduce associated noise objective function maximization problem binary similarity measure original binary halftone set randomly generated patterns optimization problem needs solved dot pattern resulting processing overhead long running time overcome restriction parallel computing techniques used decrease processing time specifically method tested using cuda based parallel implementation running gpus proposed technique produces results high visual quality acceptable processing time elsevier rights reserved
present prototype dof magnetically levitated stage based single axis lorentz force actuator capable positioning micron several millimeter travel range simple compact structure implementation lorentz force actuators instrument modeling motion controller maglev system described force gap relationship actuator solved gaussian quadrature demsional lookup table employed store result designing control system based force gap relationship choose suitable stroke actuator develop stability maglev stage complete decoupling matrix analyzed establish decoupled dynamics resulting six axis motion eight outputs actuators design travel volume stage mmxmmxmm translation mradx mradxmrad rotation constant gain critical damping pid controller resolution translation root mean square horizontal vertical direction respectively experimental results presented illustrate positioning fluctuations step responds multi axis motion comparative tests taken highlight advantage resulted accurate force gap relationship suitable stroke complete decoupling matrix
amino functionalized metal organic frameworks attracted much attention potential applications many fields catalysis adsorption separation modification work report amino functionalized mil large bet surface area successfully synthesized reduction mil prepared solvent free conditions additionally demonstrated obtained material high surface area exhibited superior catalytic activity henry reaction elsevier rights reserved
advances microfluidics introduction isothermal nucleic acid amplification assays resulted range solutions nucleic acid amplification tests suited point care field use however miniaturisation instrumentation assays seen rapid advances fluorescence based assays still depend complex bulky expensive optics fluorescence microscopes photomultiplier tubes sensitive lens assemblies work demonstrate robust low cost platform isothermal nucleic acid amplification microfluidic device using easily obtainable materials commercial shelf components show real time fluorescence detection using low cost photodiode operational amplifier without need lenses temperature regulation device achieved using heater fabricated standard printed circuit board fabrication methods facile construction methods allow fabrications cost compatible widespread deployment resource poor settings
background osteoarthritis chronic condition characterized pain impaired function reduced quality life number risk factors knee identified obesity occupation injury association knee physical activity particular sports running less clear previous reviews evidence informs present contradictory inconclusive findings purpose systematic review aimed determine association running development knee study design systematic review meta analysis methods four electronic databases searched along citations eligible articles reviews contents recent journal issues two reviewers independently screened titles abstracts using prespecified eligibility criteria full text articles also independently assessed eligibility eligible studies running running related sports triathlon orienteering assessed risk factor onset progression knee adults relevant outcomes included diagnosis knee radiographic markers knee knee joint surgery knee pain knee associated disability risk bias judged use newcastle ottawa scale random effects meta analysis performed case control studies investigating arthroplasty results duplication search returned records full text articles assessed eligible describing studies cohort retrospective case control studies findings studies diagnostic outcome mixed radiographic differences observed runners baseline within subgroups meta analysis suggested protective effect running surgery due pooled odds ratio evidence relating symptomatic outcomes sparse inconclusive conclusion evidence possible determine role running knee moderate low quality evidence suggests association diagnosis positive association diagnosis negative association knee surgery conflicting results may reflect methodological heterogeneity evidence well designed prospective studies needed clarify contradictions
health care cost consuming large portion nation gross domestic product placing added economic burdens physicians patients total joint replacement one early targeted procedures evolving health care environment knee surgeons benefit developing critical knowledge health care reforms financial implications medicare access children health insurance program reauthorization act represents cohesive movement toward value based payment reform contains several unchartered rulings require detailed attention knee surgeons article provide contextual framework health care legislation led formation current health policy present comprehensive summary update merit based incentive payment systems alternative payment models reimbursement models
recent widespread adoption service oriented architecture dynamic composition services crucial issue area distributed computing coordination execution composite web services today typically conducted heavyweight centralized workflow engines leading increasing probability processing communication bottlenecks failures addition centralization induces higher deployment costs computing infrastructure support workflow engine affordable large number small businesses end users world platforms dynamic elastic promised cloud computing decentralized dynamic interaction schemes required addressing characteristics platforms nature inspired analogies recently regained attention provide autonomous service coordination top dynamic large scale platforms paper propose approach decentralized execution composite web services based unconventional programming paradigm relies chemical metaphor provides high level execution model allows executing composite services decentralized manner composed services communicating persistent shared space containing control data flows services architecture allows distribute composition coordination among nodes proof concept given deployment software prototype implementing concepts showing viability autonomic vision service composition
aggression research often relies upon convenient samples unknown generalizability populations interest potentially threatening external validity article details measurement properties buss perry aggression questionnaire short form bpaq subscales two nationally representative samples concurrent study college students results provide useful benchmarks generalizing bpaq results convenient samples adults including distributions reliability factor structure results also confirm basic relationships trait aggression key social demographic variables sex age socioeconomic status establishing convergent validity violent political attitudes results national studies closely align student sample providing reasonable support generalizing trait aggression elements adults wiley periodicals inc
primary objective load balancing distributed systems minimize job execution time maximizing resource utilization load balancing decentralized systems need effective information exchange policy minimum amount communication nodes date information nodes system periodic event based demand information exchange important policies used approaches involve lot overhead even sometime leading toward obsolete data nodes delay updation work presents adaptive threshold based hybrid load balancing scheme sender receiver initiated approach hlbwsr using random information exchange rie rie ensures information exchanged way node system date state nodes much reduced communication overhead adaptive threshold ensures almost average numbers jobs executed nodes system study effect use rie sender initiated receiver initiated hybrid sender receiver initiated load balancing approach establishes superior performance hlbwsr among rie based peers comparative analysis hlbwsr periodic information exchange strategy modified estimated load information scheduling algorithm load balancing arrival reveals effectiveness various test conditions copyright john wiley sons ltd
article critically examines certain custom urf based assumptions theories regarding gender roles norms sunni islamic tradition law first article considers scholarship conceptualize islamic tradition next processes concept urf entered islamic tradition islamic law particular considered urf based assumptions regarding nature gender roles norms neo traditional muslim thought based term gender oppositionality thesis argue gender oppositionality thesis strongly influenced manner quran sunna interpreted respect gender issues basis patriarchal traditional islamic law ethics constructed particular highlight problematize conceptual link women fitna sources chaos male honor ird sexual jealousy ghairt discourses neo traditional interpretations islamic tradition finally article articulates traditional quran sunna hermeneutics failed recognize importance comprehensive contextualization quran sunna basis question validity gender oppositionality based interpretations quran sunna present neo traditional discourses incorporated islamic law concept custom
video games grown popularity since largest consumers video games youth populations previous research shown cognitive development learning principles video games result increasing interest games teaching tools gamification use video game elements non game applications paper proposed design study applying gamification computer programming software venvi order promote motivation engagement computational thinking
dual fluidized bed dfb systems biomass gasification consist two connected fluidized beds circulating bed material inside reactor systems rough conditions occur due high temperatures movement bed material computational fluid dynamics calculations useful tool investigating fluid dynamics inside reactor system study industrial sized dfb system simulated commercial code cpfd barracuda dfb system part combined heat power chp plant gussing situated austria total fuel input mwth model set according geometry operating data allows realistic description hot system simulation environment furthermore conversion model biomass particles implemented covers drying devolatilization processes homogeneous heterogeneous reactions considered since drag models important influence fluidization behavior four drag models tested found emms drag model fits best error whereas drag models produced much larger errors based drag law simulations conducted simulation model correctly predicts different fluidization regimes pressure drops reactor system also able predict compositions product flue gas well temperatures inside reactor reasonable accuracy due results obtained barracuda seems suitable investigations regarding fluid mechanics reactors elsevier ltd rights reserved
background aim prevailing opinion strong relation exists lack empathy antisocial personality disorder aspd however recent data fail wholly clarify relation especially consideration empathy dimensions study aim address aspd social functionality contextual behavioral science viewpoint materials methods present study conducted sample individuals aspd healthy individuals control group participants assessed sociodemographic form structured clinical interviews dsm scid scid social functioning scale sfs acceptance action questionnaire measuring experiential avoidance interpersonal reactivity index measuring empathy dimensions state trait anger scale anger related attitudes results experiential avoidance dysfunctional anger regulation patterns lack perspective taking levels higher aspd group control group experiential avoidance perspective taking processes related social functioning aspd conclusion findings may provide initial data understanding aspd clinical features related social interaction problems relations scales social functionality also analyzed discussed
idiopathic myelofibrosis rare myeloproliferative disorder children becomes even rarer herein report case idiopathic myelofibrosis year old male patient presented complaints pallor petechiae bleeding gums bone marrow aspirate showed afragmented haemodiluted smears erythroid myeloid precursors scattered throughout trephine biopsy showed increased background fibrotic activity along clusters histiocytes diagnosis paediatric primary myelofibrosis made biopsy patient also developed stroke resulted left sided hemiparesis mri suggested intraparenchymal haemorrhage along meningeal extramedullary haematopoiesis
august expert committee american food drug administration fda spoke approval medicine flibanserin meantime generally known name pink viagra contribution sheds light cultural norms socio sexual standards possibly restricting female sexual pleasure discusses risks introducing female desire pill providing critical examination traditional sexual scripts associated gender roles well associations sexuality related outcomes finally authors plead prioritizing development area sex research concepts enhance sexual pleasure genders rather bringing medicine onto market affect biochemical processes brain result series side effects despite insufficient empirical evidence effectiveness
molecular structure living organisms complex interactions amongst components basis diversity observed macroscopic level proteins nucleic acids major molecular components play key role several biological functions development evolution article presents educational bioinformatics based process designed enhance better understanding structure molecules addition using selected protein molecules attempts clarify protein organization levels related structural functional diversity define biodiversity living organisms macroscopic level framework project molecular modeling performed using cnd software created national center biotechnology information ncbi cnd user friendly application easy students get familiar quickly suggested process may easily enriched multitude protein nucleic acid molecule structures freely accessible ncbi website described process implemented students high school grade two high schools greece international union biochemistry molecular biology
propose method combines isogeometric analysis discontinuous galerkin method second fourth order geometric flows generate fairing surfaces composed multiple patches technique used tackle challenging problem geometric modeling gluing multi patches together smoothly create complex models non uniform rational splines nurbs popular representations geometric models developed computer aided design employed describe geometry represent numerical solution since nurbs basis functions two different patches independent methods appropriately applied glue multiple patches together obtain smooth solutions present semi discrete schemes solve problem stability proved proposed schemes method enjoys following advantages firstly geometric flexibility nurbs basis functions especially use multiple patches enable construct surface models complex geometry topology secondly constructed geometry fair thirdly since control points nurbs patches evolve accordance geometric flows number degrees freedom small algorithm efficient finally method easily formulated implemented apply method mean curvature flows quasi surface diffusion flows solve various geometric modeling problems minimal surface generation surface blending hole filling etc examples provided illustrate effectiveness method
investigate impact different living arrangements quality life qol health related quality life hrqol elderly used data first fourth wave korean longitudinal study aging using first wave baseline data included individuals aged years older least one living child qol hrqol measured using visual analogue scale developed korean labor institute bears similarity vas living arrangements categorized based household composition single household one generation household two generation household three generation household marital status cohabiting adult child generalized estimating equation used examine association living arrangements qol hrqol compared elderly individuals living three generation families married child single household qol beta hrqol beta living three generation family unmarried adult child qol beta hrqol beta living two generation family unmarried adult child qol beta hrqol beta likely lower qol hrqol associations particularly strong women individuals lowest equivalent household income group necessary devise government programs elderly individuals living alone also living unmarried adult child elderly persons female part lowest equivalent household income group must receive particular attention
study presents advanced computer interactive system automatic parallel connection synchronous generators load sharing control high operation speed precision dspic microcontroller used study control conditions paralleling realize connection transfer real time data among control computer environmental units long system operates thus possible monitor parameters system real time user friendly computer interface furthermore active reactive load sharing ratios generators easily set using interface system tested experimentally quite satisfactory results obtained hence used energy generation centers safely furthermore system quite convenient next generation smart grid infrastructure
purpose identification development appropriate competencies remain critical central performance measures mainstream human resource management genre towards effective teams posited viable means validating engendering best practices developing suitable competencies towards acceptable performance outcome construction project delivery purpose paper identify critical professional competencies architect ghanaian construction industry gci towards effective performance construction project delivery design methodology approach mixed method design involving semi structured qualitative interview questionnaire survey architects ghana professional architectural competencies identified respondents indicate importance effective architectural practice consulting gci five point likert scale factor analysis used explore interrelations among variables make possible empirical explanations findings factor analysis revealed four underlying clusters named order significance efficient design response client needs legal aspects practice sustainable design construction efficient project management skills study provides insight contextual practice characteristics critical professional architectural competencies needed architects construction industry ghana originality value findings rigorously revealed provided clear understanding insight thematic critical professional competencies architects important construction industry ghana focus architectural training practice also important towards developing stimulating continuous professional development agenda developing body knowledge professional practice architecture conducting curriculum review meet current emerging competency profiles necessary influencing performance levels gci
recombinant adeno associated viruses aavs quickly becoming preferred viral vector viral gene delivery treatment wide variety genetic disorders however since use clinical trial targeting hemophilia patients years ago immune responses aav capsid appear hampered early clinical gene transfer efficacy indeed aav based gene transfer shown reactivate capsid specific memory cells correlated decline aav transduced tissue patients importantly clinical trials also shown reactivation quelled administering time course taper glucocorticoid steroids dosing recently two clinical studies shown aav gene transfer able induce deleterious immune response also result initiation tolerance aav capsid mediated regulatory cells exhausted cells article reviews clinical trials describing immune responses aav well mechanisms responsible immune tolerance chronic infections could apply aav based gene transfer better understanding cytotoxic tolerogenic immune responses recombinant aav lead safer gene transfer protocols patients
forward adjoint monte carlo models radiance proposed use model based quantitative photoacoustic tomography two dimensional radiance model using harmonic angular basis introduced validated analytic solutions radiance heterogeneous media gradientbased optimization scheme used recover absorption scattering coefficients distributions simulated photoacoustic measurements shown functional gradients challenge compute efficiently using models calculated directly coefficients harmonic angular basis used forward adjoint models work establishes framework transport based quantitative photoacoustic tomography fully exploit emerging highly parallel computing architectures authors published spie creative commons attribution unported license
obesity epidemic continues increase mostly developed countries overweight obese women increased risk venous thromboembolism vte baseline much higher risk pregnancy essential help women plan pregnancies carefully use contraceptives positive ratio benefits versus risks expert group hormonal molecular contraception european society contraception convened review existing evidence propose recommendations prescribers line recent studies medical eligibility criteria world health organisation
micrornas mirnas class phylogenetically conserved non coding short rnas length suppress protein expression base pairing untranslated region target mrnas mirnas found participate cell proliferation differentiation apoptosis idiopathic pulmonary fibrosis ipf chronic progressive high lethality fibrotic lung disease currently effective treatment mirnas reported involved pathogenesis pulmonary fibrosis review discuss role mirnas pathogenesis diagnosis treatment ipf chinese pharmaceutical association institute materia medica chinese academy medical sciences production hosting elsevier open access article
large groups society particular people low literacy lack necessary proactivity problem solving skills self reliant one omnipresent problem area skills relevant regards filling forms questionnaires problems could potentially alleviated taking advantage possibilities information communication technology ict example offering alternatives text interactive self explaining scales easily accessible background information questionnaires rationale goal paper present explorative design guidelines developing interactive questionnaires low literate persons guidelines derived user centered design process dutch talking touch screen questionnaire dttsq interactive health assessment questionnaire used physical therapy dttsq developed support patients low health literacy meaning problems seeking understanding using health information decent number guidelines derived presented according existing comprehensive model also lessons learned derived including low literate persons user centered design process guidelines made available ict developers applied properly contribute advancement health literacy empower citizens fully participate society
multidimensional nuclear magnetic resonance nmr provides unique window structure dynamics atomic level traditionally given scan scan time modulation involved experiments duration nmr increases exponentially spectral dimensionality addition acquisition times increase number spectral elements sought indirect domain given ratio spectral bandwidth targeted resolution desired long sampling times substantially reduced exploiting information often available lower dimensionality acquisitions work presents novel approach exploits previous information speed acquisition spectra based denote time optimized fourier encoding tofee pre targeted peaks tofee experiments present points common hadamard encoded acquisitions necessarily require scans counterparts demonstrated based extensions heteronuclear single quantum coherence hsqc experiments hsqc tocsy hsqc noesy acquisitions theoretical basis new approach given experimental demonstrations presented small molecule protein based model systems elsevier inc rights reserved
objective examine association gestational age birth across normal spectrum weeks temperament health month old infants methods sample comprised low risk mothers infants without chronic illnesses severe pregnancy complications infant temperament defined three constructs negative affectivity extraversion regulation assessed parents reports infant behavior questionnaire infants health defined number nonroutine doctors visits attended infants since release hospital birth analyses employed continuous measure assess outcomes across gas categorical measure weeks examine contrasts results extraversion positively related primarily due lower scores infants born weeks compared infants born weeks showed similar effect odds infants born weeks attending nonroutine medical visit times infants born full term discussion infants born weeks express less affect use nonroutine medical services infants born weeks findings underscore importance considering risks pregnancy prolongation developmental risk associated early term delivery
case control study found association seasonal affective disorder sad single nucleotide polymorphism intronic gene encoding gpr orphan member protein coupled melatonin receptor subfamily females may represent gender specific risk factor molecular link melatonin sad elsevier masson sas rights reserved
using administrative child welfare data ontario child abuse neglect data system ocands study compared profiles asian canadian white canadian children families experienced case closure investigation instead transferred ongoing child protection services cps child protection investigations involving asian canadian white canadian children families transferred ongoing cps presented different profile case characteristics caregiver child clinical needs asian canadian children families received ongoing cps month longer white canadian children families less likely odds ratio reinvestigated form maltreatment related concerns within year case closure appears child protection investigations involving asian canadian children families less likely closed prematurely white canadian children families child protection system may meeting needs asian canadian communities alternatively possible unaccounted biases may reflective systemic problem discriminative practices child protection system research needed explore phenomenon
rapid development mobile technologies people easily obtain surrounding information mobile devices meanwhile weather forecasting information important many people daily life current weather information systems illustrate basic weather information temperature precipitation probability simple text based graphic based presentation without involving much environmental information integrate weather information ambient intelligence paper aims showing implementation experience realize ambient mesoscale weather forecasting system amwfs augmented reality presentation system intuitive navigation interface provides users new way accessing weather information
evaluate compare diagnostic potential different reading protocols entailing non enhanced contrast enhanced diffusion weighted fdg pet imaging lesion detection determination tumor stage lymphoma patients total fdg pet mri datasets including transverse haste fdg pet pet mri additional contrast enhanced vibe pet mri additional diffusion weighted imaging pet mri evaluated scans performed initial staging restaging treatment end treatment surveillance suspicion tumor relapse datasets lymphoma manifestations well tumor stage analogy revised criteria ann arbor staging system determined furthermore potential changes therapy compared reference standard evaluated hitherto performed pet available follow prior examinations well histopathology served reference standard pet mri correctly identified patients active lymphoma lesions respective values pet mri pet mri pet mri determined correct tumor stage examinations corresponding results pet mri pet mri relating reference standard changes treatment would occur based pet mri based pet mri based pet mri additional application contrast enhanced diffusion weighted imaging fdg pet mri resulted higher diagnostic competence particularly initial staging correct classification disease extent potential impact patient therapy management
past years research corporate scandals evidenced destructive effects dark triad work consisting narcissism extreme self centeredness psychopathy lack empathy remorse machiavellianism sense duplicity manipulativeness dark triad dimensions typically conceptualized stable personality traits ignoring accumulating evidence momentary personality expressions personality states may change due characteristics situation present research protocol describes qualitative study aims identify triggers dark triad states work following grounded theory approach using semi structured interviews building comprehensive categorization dark triad triggers work scholars may study triggers parsimonious structured way organizations may derive effective interventions buffer prevent detrimental effects dark personality work
background study assessed feasibility acceptability pharmacy home based sexually transmissible infection sti screening alternate testing venues among emergency contraception users methods study included two phases february july phase customers purchasing eight pharmacies manhattan received vouchers free sti testing onsite medical clinics phase three facebook ads targeted users connect free home based sti test kits ordered online participants completed self administered survey results participants enrolled phase female click throughs completed survey requested kits returned phase participants younger less educated phase participants six tested positive stis challenges included recruitment pharmacy staff participation advertising discretion cost conclusions study found low uptake pharmacy home based testing among users however sti testing settings feasible acceptability findings indicate appeal among younger women testing non traditional settings collaborating training pharmacy medical staff key elements service provision future research explore different permutations expanding screening non traditional settings could improve testing uptake detect additional sti cases
aim paper employ digital fractional order proportional integral derivative pid controller speed control buck converter fed motor optimal pole zero approximation method discrete form proposed realization digital fractional order controller stand alone controller implemented embedded platform using digital signal processor tmsf five tuning parameters controller enhance performance control scheme tuning controller parameters dynamic particle swarm optimization technique employed proposed control scheme simulated matlab verified experimental results performance comparison shows better speed control separately excited motor realized digital pid controller integer order pid controller
aim study investigate incidence risk factors handball injuries brazilian elite handball players overall athletes handball teams participated two main brazilian championships followed season total injuries reported athletes injury incidence rate training matches matches ankle knee body regions affected traumatic injuries shoulders knee body regions affected overuse injuries muscle injuries traumatic injury type reported tendinopathy overuse injury type observed previous injury additional match per week associated higher risk overuse injury female athletes additional hour training per week associated higher risk traumatic injury study showed athletes previous injury shown high risk developing overuse injury
study performed examine role harsh parental discipline mediating moderating effects environmental adversity family socioeconomic disadvantage adverse life events emotional behavioral problems across early middle childhood sample included children female non white millennium cohort study analyzed trajectories conduct hyperactivity emotional problems measured ages years using growth curve models harsh parental discipline measured ages parent reported items frequency using physical verbal discipline tactics smacking shouting telling child expected family socioeconomic disadvantage adverse life events significantly associated emotional behavioral problems harsh parental discipline related children trajectories problems moderated explain effect environmental risk trajectories high risk children experiencing harsh parental discipline highest levels conduct problems hyperactivity across study period addition harsh parental discipline predicted increase emotional symptoms time high risk children unseen counterparts experiencing low levels harsh parental discipline however children low risk families also negatively affected harsh parental discipline concurrently time conclusion harsh parental discipline predicted emotional behavioral problems high low risk children moderated effects family poverty adversity problems
psoriasis managed successfully long term biologics real life clinical practice may require dose tapering therapeutic option reduce risk drug exposure increase cost effectiveness responsiveness extended intervals adalimumab doses possible predictive factors maintenance complete clearance studied retrospective year single centre analysis thirty patients achieved complete clearance adalimumab underwent dose tapering progressively extending dose intervals days sixty percent subjects group maintained complete clearance whereas group relapsed switched back standard dosage achieve complete clearance body mass index bmi time achieve psoriasis area severity index pasi adalimumab standard treatment dose tapering significantly lower group group multivariate cox regression kaplan meier analysis respectively study suggests patients lower bmi shorter time achieve pasi adalimumab standard dose significantly likely candidates dose tapering
background hepatocellular carcinoma hcc frequent type liver cancer occurrence oral cavity metastatic neoplasm rare event describe fatal case hcc oral metastasis patient firstly diagnosed prostatic hepatic carcinomas histopathological examination revealed hepatocyte like tumour cells arranged organoid structures well positivity cytokeratin hep par present findings highlight importance complete medical evaluation patient identify possible oral repercussions primary diseases
effects impeller configurations docosahexaenoic acid production flow characteristics investigated schizochytrium bioreactor straight blade disc turbine sbdt arrowy blade disc turbine abdt pumping propeller dpp combined form different impeller configurations simulated results showed configuration ssa consisting upper two sbdt one bottom abdt possessed worst oxygen supply capacity obtained highest dha percentage dha yield indicating beneficial dha synthesis converting glucose biomass lipids configuration sas consisting one middle abdt two sbdt provided better mixing capacity resulted maximum glucose consumption rate highest biomass study would improve insight understanding relationship flow field physiology schizochytrium scale industrial dha production
background peanut allergies common life threating sensitised individuals peanut allergens share significant amino acid homology legumes tree nuts cross reactivity still remains unclear objective sought determine clinical significance cross reactivity peanut allergens walnut soybean methods pooled sera eight subjects peanut walnut specific ige investigated inhibition test sera incubated either peanut walnut protein extracts quantity ige antibodies peanut walnut measured using immunocap test likewise pooled sera subjects peanut soybean specific ige antibodies incubated either peanut soybean protein extracts evaluated peanut soybean immunocap test sds page immunoblotting also performed peanut walnut soybean protein extracts relevant sera results peanut specific ige inhibited walnut soybean protein extracts respectively reverse walnut soybean specific ige inhibited peanut protein extracts respectively immunoblot analysis pooled serum subjects peanut specific ige antibodies reacted walnut protein extracts significantly conclusion although clinical significance cross reactivity peanut specific ige walnut soybean protein extracts established believe individuals allergic peanuts need cautious consuming walnuts soybeans seicap published elsevier espana rights reserved
time dependent behavior soils investigated extensively using one dimensional triaxial tests phenomena associated time effects soils creep relaxation strain rate arrangement effects engineering properties soil often improved significantly elapse time objective paper investigate time dependent effect shear strength parameters sand geosynthetic interface using large direct shear test apparatus purpose geotextile layer carefully adhered piece rigid block thickness half shear test box occupied half box filled sand test performed three normal stresses kpa applied tests shear stress subsequently applied different times failure stage tests shearing velocity kept results experiments show stiffuess friction angle sand geotextile interface increases minutes sample poured mold increases occur mostly first two hours following normal stress application samples findings paper interesting consider practice
study electric vehicle based thermal management system designed dual energy sources experimental platform developed previous study modified regarding mechanical components heat exchanger radiator proportional valve coolant pipes coolant pump appropriately integrated regarding electric components two heaters emulating waste heat controlled using two programmable power supply machines rapid prototyping controller two temperature inputs three outputs designed rule based control strategies coded maintain optimal temperatures emulated proton exchange membrane fuel cells lithium batteries evaluate heat power dual energy sources driving cycles energy management control efficiency maps energy sources considered deriving time variant values main results follows advanced mechatronics platform constructed driving cycle simulation successfully conducted coolant temperatures reached optimal operating ranges proportional valve radiator coolant pump sequentially controlled benefits novel electric vehicle based thermal management system high efficiency operation energy sources low occupied volume integrated energy sources higher electric vehicle traveling mileage system integrated real energy sources real electric vehicle future
published margaret deland iron woman depicts transformation american cultural scene second half nineteenth century affected powers industrialization modernity intellectuality reflecting extensive change social landscape cultural ideology gender roles family relations novel presents unique exploration motherhood experience argue study deland reconceptualizes female maternal experience defying already established ambivalent discourse mothers american culture ambivalence exposed challenged iron woman confined motherhood within different power relations seek codify lives mothers religiously culturally socially psychologically although lived pre feminist era deland able anticipate modern feminist argument motherhood characterization real mothers struggle society resist conforming traditional idealization essentialist prototypes accompany mother figures american cultural mind major concern study discuss deland challenges number cultural codes motherhood religiously idealized virgin mary socially constructed true woman newly introduced modernist new woman stepping beyond dual ambivalent discourse glorifies mothers one hand blames margaret deland forges new maternal path mother characters resist inconsistency culturally embedded notions motherhood codify perpetuate restrictive mother image neglecting actual experiences mothering
prostaglandins small pro inflammatory molecules derived arachidonic acid play roles multitude biological processes including limited inflammation pain modulation allergies bone formation prostaglandin analogues front line medications treatment glaucoma condition resulting blindness due death retinal ganglion cells drugs act lowering intraocular pressure iop major risk factor glaucoma currently used prostaglandin analogues latanoprost bimatoprost tafluprost travoprost mimic pgf target one prostaglandin receptors though research harnessing receptors using compounds like sulprostone receptor iloprost receptor currently ongoing review summarize research prostaglandin molecules pgd pge pgf pgi txa respective receptors examine modes action receptors expression role aqueous humour production outflow within eye well roles medications treatment glaucoma
rice oryza sativa dominated rainfed uplands eastern india facing two major problems lack irrigation water sources low productivity fact unlined farm pond ofp technology terrain could prove effective agricultural drought mitigation measure monsoon crops failed ensure supplemental irrigation next winter crops consequently ofp technology could pick region order overcome shortcomings technology location ofp changed new concept partial rice substitution prs introduced present study provide second crop winter maize zea mays rice crops upper lower compartments field respectively tried various crop substitution ratios csr monsoon season rainfall excess compartments harvested unlined ofp located compartments used providing winter black gram vigna mungo mustard brassica campestris taken upper lower compartments respectively based availability water ofp water balance models used simulate soil moisture crop root zone well storage water ofp optimal size unlined ofp average land holdings rainfed uplands csr found occupying area crop field
recently big effort focused research smart environments learning area already resulted number interesting projects results smart environments learning based approaches technologies deployed related areas ambient intelligence smart environments certainly deserve considerable attention large community oriented technology enhanced learning smart environments learning naturally considered new challenging step computer enhanced learning evolution many new interesting facilities multi agent systems frequently used approach towards smart environments design general systematic approach towards reflecting desirable functionalities smart learning environments based well designed multiagent architecture moreover number new technologies approaches influenced recent research area smart learning environments let mention cloud based architectures applications representative contribution tries summarize recent state art area stressing main features successfully implemented projects couple unsolved problems presented together vision possible future evolvement smart learning environments
despite limited evidence complementary alternative medicine treatments popular autism spectrum disorder aim review summarize available evidence complementary alternative medicine use frequency autism spectrum disorder systematic search three electronic databases performed research studies english german reporting data frequency complementary alternative medicine use individuals autism spectrum disorder included two independent reviewers searched literature extracted information study design results assessed study quality using established quality assessment tool twenty studies total participants included prevalence complementary alternative medicine use ranged median special diets dietary supplements including vitamins frequent complementary alternative medicine treatments ranking first studies evidence higher prevalence complementary alternative medicine use autism spectrum disorder compared psychiatric disorders general population approximately half children adolescents autism spectrum disorder use complementary alternative medicine doctors aware discuss complementary alternative medicine use patients carers especially evidence mixed complementary alternative medicine treatments potentially harmful
oil sands mining region near fort mcmurray alberta strategies construct wetlands peatlands methods evaluate success beginning reclamation wetlands particularly challenging region growing seasons short precipitation variable often limiting presence elevated salinity associated mining process harmful vegetation part reclamation programme syncrude canada ltd constructed series test plots termed cells examine specific procedures management strategies associated wetland reclamation study water balance cells similar area different soil vegetation treatments studied two growing seasons understand influence soil salvage vegetation placement strategy water balance components cells constructed summer winter either stockpiled material planted vegetation soils directly transplanted nearby wetland iii soil depths cells built liner eliminate leakage watered using irrigation system along receiving precipitation inputs cells irrigated similar water tables maintained near surface duration growing season cells watering reduced considerably water tables average much lower evapotranspiration losses measured using lysimetres varied throughout season among cells rates greater wet conditions surface cells placed winter shallower organic soils also enhanced cumulative water balance suggests cells considerable leakage despite constructed atop geotextile copyright john wiley sons ltd
goal present paper investigate whether soccer referees nonverbal behavior nvb differed based difficulty decisions whether perceivers could detect systematic variations one hand communicating confidence via nvb emphasized referee training hand seems feasible theoretical point view particularly following relatively difficult decisions referees problems controlling nvb conducted three experiments investigate question experiment experiment provided evidence perceivers regard referees nvb less confident following ambiguous decisions compared following unambiguous decisions experiment suggested perceivers likely debate referee referees nonverbally communicated less confidence discuss consequences referee training
increasing availability high resolution images videos models demand scalable large data processing techniques increases introduce method sparse dictionary learning edit propagation large input data previous approaches edit propagation typically employ global optimization whole set pixels vertexes incurring prohibitively high memory time consumption large input data rather propagating edit pixel pixel follow principle sparse representation obtain representative compact dictionary perform edit propagation dictionary instead sparse dictionary provides intrinsic basis input data coding coefficients capture linear relationship pixels dictionary atoms learned dictionary optimized novel scheme maximizes kullback leibler divergence atom pair remove redundant atoms enable local edit propagation images videos similar appearance dictionary learning strategy proposed considering range constraint better account global distribution pixels feature space show several applications sparsity based edit propagation including video recoloring theme editing seamless cloning operating color texture features approach also applied computer graphics tasks surface deformation demonstrate atom pixel ratio order signifying significant reduction memory consumption method still maintains high degree visual fidelity
organic bilayer comprising type perylene derivative ptcbi type lead phthalocyanine pbpc prepared examined terms photoelectrode water phase ptcbi pbpc bilayer functioned photoanode generated photocurrent due oxidation reactant fell pbpc surface furthermore organo bilayer also induced photocatalytic reaction originated oxidising reducing powers produced pbpc ptcbi respectively based photoelectrochemical photocatalytic studies noted ptcbi pbpc bilayer respond wide spectrum solar energy however using metal free phthalocyanine hpc type reference type layer application photocatalyst material combination ptcbi generated ptcbi hpc bilayer show photocatalysis particularly control irradiation thus present work demonstrated utilisation photocatalytic material responding near infrared energy effective towards efficient output product elsevier rights reserved
continuing challenge education system evaluate wider outcomes schools wider measures success citizenship lifelong learning influence emerge time complex interactions students teachers leaders wider community unless methods found evaluate broader outcomes able justice learning achievement emergent properties learner engagement world education system continue focus narrow measures school effectiveness properly account complexity article describe rationale methodology underpinning pilot research project applied hierarchical process modelling group schools complex living systems using software developed engineers university bristol called perimeta aim generate stakeholder owned systems design better able account full range outcomes valued school complex processes facilitate inhibit thus providing nuanced leadership decision making analytic project involved three academies
postnatal depression pnd common negatively affects mother infant relationship oxytocin found positive effects parenting although psychiatric disorders may reduce effects thus explored role mothers diagnosed pnd within subject randomized controlled double blind design used test effects nasal administration placebo sensitive caregiving outcome measures perceptual caregiving responses prerecorded cry sounds well observed maternal sensitivity found condition mothers pnd likely rate infant cry urgent likely indicate would chose harsh caregiving strategy response effect maternal sensitive interaction baby research required prior consideration administration depressed mothers infants
investigate abnormal brain activities early stage parkinson disease electroencephalogram eeg signals recorded channels non dementia patients patients females age matched healthy controls subjects females resting state two methods based ordinal patterns recorded series permutation entropy order index introduced characterize complexity cortical activities two groups observed resting state eeg patients showed lower higher healthy controls indicated early stage caused reduced complexity eeg applied two methods determine complexity eeg rhythms five sub bands results showed gamma beta alpha rhythms patients characterized lower higher reduced complexity healthy subjects significant differences observed theta delta rhythms two groups findings suggested promising methods detect abnormal changes dynamics eeg signals associated early stage changes eeg complexity may early markers cortical subcortical dysfunction caused
objectives elaborate impact family planning training general practitioners knowledge attitude practices regarding emergency contraception methods cross sectional survey involving general practitioners conducted hyderabad oct dec participants divided two groups basis attending family planning training course graduation interviewed face face data noted questionnaire asking knowledge attitude practices regarding emergency contraception data analyzed spss version student test applied compare proportions among two groups results general practitioners male female participants respectively mean experience private general practitioner years one third participants attended five days training course family planning past training source training government institutes non government organization cases significant positive difference noted emergency contraception knowledge attitude use group attended family planning training conclusion educational intervention positive impact health care provider knowledge attitude practices emergency contraception
purpose review various environmental occupational medical substances cause dysregulation autoimmunity effects causative mechanisms silica particles asbestos fibers discussed review recent findings respect silica many epidemiological studies shown significant association silica exposure occurrence autoimmune diseases although importance nacht lrr pyd domains containing protein nalp inflammasome initial immune reaction silica particles identified mechanisms involved lead various autoimmune diseases patients exposed silica remain largely unknown silica activate various immune cells investigation associated imbalance regulatory cells responder cells well cells might key furthering understanding silica induced autoimmune alterations hand asbestos exposure shows less association autoimmune diseases however interesting findings pertaining detection antiendothelial mesothelial cell antibodies asbestos exposed patients reported summary taken together investigations may contribute delineating mechanisms involved environmental factor induced modification autoimmunity
van allen experimentally observed magnetic moments planets stars proportional angular momentum orders magnitude graph purely empirical regarded disdain theorists planetary magnetism van allen paper develop model predicts proportionality magnetic moment angular momentum also fits experimental results adjustable parameters model based fact rotating planet star immersed nonrotating conducting plasma cloud constitutes faraday electrical generator faraday generator assumed primary source magnetic field contrast present models assume flow magma planets cores responsible
describe core elements modern psychiatric rehabilitation based selected examples describe discussion values mental health care focus europe present outcome data studies tried implement care structures based value discussion second half century mental health care european high income countries changed conceptually structurally deinstitutionalisation reduced number psychiatric beds transferred priority outpatient care community based services community mental health programs developed differently across within countries high income countries europe continued invest costly traditional services neither evidence based person centered emphasising inpatient services sheltered group homes sheltered workshops argue evidence based person centred recovery oriented psychiatric rehabilitation offers parsimonious solution developing consensus plan community based care europe challenges scaling effective psychiatric rehabilitation services high income countries primarily lack resources rather lack political inefficient use dysfunctional allocation resources
service quality management become recent phenomenon thus necessary service consumers quickly understand service provided different vendors service review systems srs paper considers trustworthy srs location based service without trusted review management center oriented mobile social networks msns propose review statistic modification attacks service consumers review service protecting security reduce communication computation overhead srs srs based mobile cloud computing mcc constructed also prevent attacks existing srs guarantee trustworthiness statistic srs data entanglement verifiable service utilization tickets used simulation results show scheme could effectively resist proposed service review attacks efficient review submission review authenticity verification
orthogonal modulation example frequency shift keying fsk pulse position modulation ppm primarily used relatively low rate communication systems operate power limited regime optimal noncoherent detection orthogonally modulated signals takes form sequence detection exponential sequence length complexity implemented exhaustive search among possible sequences work first time literature present algorithm performs generalized likelihoodratio test glrt optimal noncoherent sequence detection orthogonally modulated signals flat fading log linear sequence length complexity moreover rayleigh fading channels proposed algorithm equivalent maximum likelihood noncoherent sequence detector simulation studies indicate optimal noncoherent fsk detector attains coherent detection performance sequence length order offering gain typical energy single symbol detector conventional exhaustive search approach becomes infeasible sequence lengths proposed implementation requires log linear number operations opening new avenues practical deployments finally show algorithm also solves efficiently optimal noncoherent sequence detection problem contemporary radio frequency identification rfid systems
accumulating evidence indicates small subset cancer cells termed tumor initiating cells cancer stem cells cscs construct reservoir self sustaining cancer cells characteristic ability self renew maintain tumor mass cscs play important role tumor initiation development relapse metastasis ineffectiveness conventional cancer therapies ligand signal regulatory protein alpha expressed phagocytic cells functions inhibit phagocytosis study explore expression mechanism used lung cancer cells especially cscs escape phagocytosis vitro vivo selected marker lung cscs according previous reports analyzed lung cancer matched adjacent normal non tumor tissue revealed overexpressed lung cancer cells especially lung cscs mrna expression levels correlated decreased probability survival multiple types lung cancer blocking function anti antibodies enabled macrophage phagocytosis lung cancer cells lung cscs anti antibodies inhibited tumor growth immunodeficient mouse xenotransplantation models established lung cancer cells lung cscs improved survival tumor bearing animals data indicate valid target cancer therapies especially anti csc therapies
proper initialization fractional order operators ongoing problem particularly application laplace transforms correct initialization terms last years history function based initialization along corresponding laplace transform presented alternatively infinite dimensional state space representation along corresponding laplace transform also presented purpose paper demonstrate two approaches initialization problem fractional order operators equivalent associated laplace transforms yield correct initialization terms used solution fractional order differential equations
objectives prior studies suggest composition vaginal microbiome may positively negatively affect susceptibility sexually transmitted infections stis bacterial vaginosis female hormonal contraceptive methods also appear positively negatively influence sti transmission therefore changes vaginal microbiome associated different contraceptive methods may explain part effects sti transmission study design performed retrospective study rrna gene survey data vaginal samples subset participants human vaginal microbiome project virginia commonwealth university subset included women reported using single form birth control condoms combined oral contraceptives cocs depot medroxyprogesterone acetate dmpa levonorgestrel releasing intrauterine system lng ius results women using cocs adjusted odds ratio aor confidence interval dmpa aor lng ius aor less likely colonized associated bacteria relative women used condoms women using cocs aor likely colonized beneficial producing lactobacillus species compared women using condoms women using dmpa aor lng ius aor conclusions use cocs significantly associated increased vaginal colonization healthy lactobacilli reduced associated taxa
nowadays lean thinking proven effectiveness reducing wastes boosting manufacturing performances unfortunately foolproof way implement lean principles must always reinterpreted fit specific requirements industry need applied remains constant every implementation first status quo company must understood envisaging lean solutions necessity even strategic manufacturing environments performances depend several interrelated parameters high variety low volume hvlv job shops paper tackles problem introducing multiple values stream mapping vsm innovative framework integrating values stream mapping tools typical manufacturing engineering although framework flexible nature focuses work load control since hybrid technique recognized literature main choice hvlv job shop systems order demonstrate quality practical utility vsm introduced step step using case study taken example
neuromedin nmu neuropeptide known regulate food intake energy homeostasis widely distributed gastrointestinal tract hypothalamus pituitary short form nmu porcine nmu potent agonist activity receptors nmur nmur however short half life precludes effective use vivo address limitation designed synthesized nmu analogs modified polyethylene glycol peg molecular weight kda pegk via variety linkers amino imino carboxylic acid linker integrated evaluation nmur nmur binding affinities vitro anorectic activity mice revealed introduction linker rigid ring group piperazin acetic acid pipac yielded highly potent anorectic peptide pegkpipac nmu possessing improved receptor binding affinity subsequent optimization molecular weight peg moiety led discovery pegc conjugate exhibited significant anti obesity effect upon daily subcutaneous administration diet induced obese mice body weight loss doses nmol respectively addition reduced weights liver adipose tissue dose dependent manner improved plasma biochemical parameters insulin glutamic pyruvic transaminase glutamic oxaloacetic transaminase total cholesterol thus results suggest nmu showed potent long lasting biological profiles vivo represents candidate peptide investigating central peripheral actions nmu potential clinical use elsevier ltd rights reserved
today globalized environment exposes people culture mixing mixing iconic symbols different cultures space time findings individuals exposure culture mixing provide evidence exclusionary inclusionary responses article focus growing phenomenon culture mixing global local symbols artifacts generate conceptual model identify likely respond way mixed cultural environment answer questions build global acculturation model aims explain individuals adaptation global environment considering relative strength local global identities extend model considering two entities relative strength also balance degree symmetry identities strength propose individuals dominant unbalanced identity types global local exhibit negative exclusionary responses culture mixing whereas individuals balanced identity types glocal marginal exhibit positive inclusionary responses culture mixing also incorporate concept bicultural identity integration bii suggest individuals high identification cultures glocals high bii exhibit inclusive responses glocals low bii theoretical practical implications discussed
introductionto determine current hospital practices opinions senior health professionals working western australian hospitals performing gynaecological procedures regarding pre operative pregnancy testing methodsanonymous questionnaire survey sent public private hospitals senior clinical staff units gynaecological surgery performed resultssixty one senior health professionals heads department medical directors theatre nurse managers completed survey estimated response rate thirty eight respondents units guidelines pre operative pregnancy testing respondents worked hospitals tested women reproductive potential nineteen respondents reported cases patients presented surgery unaware pregnant forty one respondents believed women reproductive potential routine pre operative pregnancy testing fifty four supported introduction national statewide guidelines discussionthere inconsistent processes pre operative assessment pregnancy status hospitals performing gynaecological surgery potentially resulting adverse incidents majority senior clinical staff surveyed supported routine pre operative testing need national statewide guidelines
efficiently effectively detecting shell like structures particular shapes important task computer vision image processing paper presents generalized possibilistic means algorithm pcm shell clustering based diversity index degree lambda proposed patil taillie diversity concept measurement amer statist assoc experiments various data sets wang possibilistic shell clustering template based shapes ieee trans fuzzy syst show proposed generalized pcm performs better wang possibilistic shell clustering template based shapes ieee trans fuzzy syst possibilistic shell clustering method according two two criteria grade detection target cluster amount computation denoted required attain given
objective determine impact informed contraceptive counseling choice contraceptive method methods multicenter descriptive study using evaluation nine cities colombia women considering use self administered combined hormonal methods time consultation invited participate asked contraceptive method use preference following signing informed consent later given standardized medical advice contraception asked contraceptive preference reasons choice results study enrolled women beginning study women using combined pill using contraceptive method receiving counseling women showed preference pill followed intravaginal ring transdermal patch counseling preferences follows pill intravaginal ring transdermal patch counseling considering pill patch ring respectively changed intended choice region origin employment status desire conceive child future stable relationship showed statistical relationship choice method however age number children level education determining factors conclusions medical advice impact choice self administered combined hormonal contraceptives helps women use method choice improves adherence method accordance particular conditions
argue commonality federal states face dilemma sub unit autonomy collective problem solving develop structure dilemma pervasive multilevel systems strong element shared policy making pronounced substantial part federalism literature considers relationship precarious discusses ways stabilize propose analytical perspective focuses actor dynamics attempts subunits change balance sub unit autonomy collective problem solving changing position two distinct dimensions exit voice exit measures degree sub units want subject collective policies voice measures influence sub units seek collective decisions illustrate framework examples mainly conclude perspective shed new light differentiated integration open comparative inquiries
study presents novel approach based four electrode electrochemical biosensor detection tau protein one possible markers prediction alzheimer disease biosensor based formation stable antibody antigen complexes gold microband electrodes covered layer self assembled monolayer protein antibodies immobilized gold electrode surface optimal orientation protein interaction electrochemical impedance spectroscopy used analyze impedance change revealed linear response increasing tau concentrations assay fast incubation measurement sensitive limit quantification full length tau protein value unaltered assay processed bovine serum albumin human serum technology could adapted detection biomarkers provide multiple assay identify progression point care setting
mathematical model propagation flooded mine lightweight contaminant due allocation groundwater considered mathematical model based analysis experimental data using concept methods reactive media mechanics boundary value problem solved numerically using finite volume method distribution fields velocities concentration impurity particles flooded mine obtained different times results used analyze mining water treatment process due environment evaluate possible improvements
lack hands experiences specific manufacturing processes identified one major competency gaps manufacturing engineering education partly response funding agencies like sme education foundation smeef national science foundation nsf supported efforts address issue paper describes manufacturing integrated learning lab mill outcome efforts mill nsf funded multi institutional project whose focus development hands approach manufacturing education offers students skills directly prepare careers manufacturing design product realization four knowledge areas corresponding detailed learning outcomes identified study namely drafting design manufacturing process process engineering cad cam based core curriculum shared partner institutions developed encapsulates mill manufacturing competency model assessment instruments measure student learning also developed sample test items developed competencies series internal meetings held among mill project staff preliminary results field test indicate high levels student achievement mill paradigm excellent structure assessment instruments
paper describes computationally efficient parallel computing framework mesoscopic transportation simulation large scale networks introducing overall data structure mesoscopic dynamic transportation simulation discuss set implementation issues enabling flexible parallel computing multi core shared memory architecture first embed event based simulation logic implement simplified kinematic wave model reduce simulation overhead second present spacetime event computing framework decompose simulation steps reduce communication overhead parallel execution openmp based space time processor implementation method used automate task partition tasks according spatial temporal attributes various types simulation events mapped independent logical processes concurrently execute procedures maintaining good load balance propose synchronous space parallel simulation strategy dynamically assign logical processes different threads proposed method applied simulate large scale real world networks examine computational efficiency different numbers cpu threads numerical experiments demonstrate implemented parallel computing algorithm significantly improve computational efficiency reach speedup workstation computing threads elsevier ltd rights reserved
india largest democracy world elections forms cornerstone country amongst prominent leaders representative chosen run country seek search public affairs pieces legislation constitutional amendments onerous task maintain transparency electoral process shield integrity elections make equitable withstand fraudulence rampage free elections one critical issues today state affairs like finding needle haystack needs eye lots money spent ensure elections fair unprejudiced privacy also important make elections equitable prevent voter coercion intimidation ballot selling nowadays seen many unwanted forces indulged bogus voting recently also criticized election irregularities leads ambiguity polling results actual verdict given people classical poll site voting methods along many computer based voting system poise several administrative logistic challenges terms cost voter misinterpretation tally votes paper proposes new state art electronic voting machine design quest election legitimacy provide inexpensive solution based pragmatic biometric system using fingerprint detection along inclusion near far communication technology
study materials focused specific theories essential element education universities types study materials generally available universities advantage disadvantage types study materials high theoretical content however engineering companies require graduates able apply knowledge practice therefore new concept learning study materials developed new learning study materials focused projects industrial practice students better acquire theoretical knowledge learn practical techniques using new study materials another advantage high comprehensiveness study materials several example projects projects one machine every machine accompanied complete drawing documentation calculation reports welding technology pdf etc one machine chosen descriptions study materials individual parts
canadian digestive health foundation initiated scientific program assess incidence prevalence mortality economic impact digestive disorders across canada current article presents updated findings study concerning inflammatory bowel diseases specifically crohn disease ulcerative colitis
many aerosol retrieval algorithms based remote sensing technology developed applied produce aerosol optical depth aod products different satellite sensors dark target deep blue algorithms two main modis aerosol retrieval algorithms suitable dark bright areas estimation land surface reflectance lsr necessary improve accuracy aod retrievals therefore paper new procedure improve lsr estimation using modis surface reflectance products developed new high resolutionaerosol retrieval algorithm priori lsr database support harls proposed purpose paper evaluate spatial adaptability different modis aod products produced three algorithms beijing tianjin hebei jing jin region features complex surface structures serious air pollution chosen study area different aod products validated using aerosol robotic network aeronet aod ground measurements four stations located dark bright areas comparedwith retrievals approximate aod retrievals yield stronger correlation approximate aeronet aod lower rmse mre mae values resulting approximately less average overestimation dbaodresults showa retrieval quality approximate similar approximately collections falling within expected error moreover much better approximately collections falling within however harls achieves high correlation approximate aeronet aods low rmse approximate andmae approximate small offsets intercept approximate harls retrievals exhibited less uncertainty retrievals less uncertainty retrievals less uncertainty retrievals harls achieves greater accuracy reliability aodretrieval less biased rmb approximate better overall routine modis aerosol products jing jin region
introduction aim elucidate relationship annual changes respiratory system impedance measured fot lung function tests patients asthma methods march march asthma outpatients attended kobe city medical center west hospital recruited lung function tests fot conducted every months march relationships annual parameter changes evaluated results conclusion sixty four patients completed study median follow period months enrollment although resistance showed relationship forced expiratory volume one second fev reactance moderately correlated fres alx contrast annual resistance change highly significantly associated fev change longitudinal changes airway resistance reactance measured fot might useful assessment lung function patients asthma elsevier rights reserved
background several studies shown effects polychlorinated biphenyls pcbs serum thyroid hormone levels pregnant woman infants studies find effects pcbs might affect thyroid hormone metabolism still unclear potential mechanisms direct influence thyroid gland binding thyroid binding proteins increased excretion metabolism thyroid hormones deiodinases sulfatases also well known whether effect thyroid hormone levels caused pcbs hydroxylated metabolites pcbs objective determine effects perinatal exposure pcbs pcbs thyroid hormone levels cord blood serum newborn infants methods dutch cohort mother infant pairs exposed background pcb levels correlations assessed pcbs pcbs maternal blood pregnancy serum thyroxine sulfate triiodothyronine reverse thyroid stimulating hormone tsh thyroxine binding globulin tbg levels cord blood serum three month old infants corrected age mother gestational age gender type feeding results correction prenatal levels three measured pcbs showed positive correlation cord serum four pcbs showed negative correlation cord serum correction two pcbs sum measured pcbs positively correlated cord serum ratio indicator deiodinase activity correlations found pcbs tsh tbg cord blood pcb correlated months months conclusion results suggest pcbs negative effect deiodinase type activity reflected positive correlation ratio identified potential mechanism pcbs may affect thyroid hormone metabolism human development elsevier rights reserved
top supercomputers ranking held twice year according linpack performance years greatly stimulates development high performance computing however still clear determine scale limit supercomputers undoubtedly cause waste resources build bigger bigger supercomputers without caring aspects cost energy reliability thus paper analyses scalability scale limit parallel computing reliability requirement use markov chain model state transition process parallel computing system probability parallel tasks running machines successfully evaluated reliability parallel computing parallel computing carries iso speed efficiency extension specific reliability requirements present approach calculate maximum number processing nodes maximum workload parallel tasks actually reveals function relation scale limit speed efficiency parallel computing taking tianhe current supercomputer example utilize methods case study predict scale limit finally simulation experiment conducted verify theory
reduction radar cross sectional area achieved stealth technology major challenge since second world war accomplished covering metallic surfaces aircraft ships tanks etc radar absorbing materials nowadays development lightweight microwave absorbing materials reduced thickness greater impact due excellent microwave absorbing properties study microwave absorbing properties nanocomposites based substituted cobalt ferrite lead zirconium titanate investigated band ghz ghz region substituted cobalt ferrite czf lead zirconium titanate pzt nanoparticles prepared coprecipitation homogeneous precipitation method respectively nanocomposites developed dispersing nanoparticles different compositions epoxy resin matrix composite materials showed microwave absorption band region nanocomposite containing czf pzt thickness displayed maximum return loss ghz microwave absorbers based epoxy resin polymeric matrix exhibited better absorbing properties dielectric contribution matched magnetic contribution loss mechanisms mainly due dielectric loss
airborne respirable dust ard stable environment strongly implicated equine asthma bedding forage ventilation rate stable management activities contribute ard study investigated relationship ard breathing zone stable zone eight american barns abs eight stable complexes individual stables four different management regimes airborne respirable dust measured eight replicate stables per regime abs eight per regime single stables regimes follows steamed hay shavings dry hay shavings haylage straw dry hay straw samples taken quite periods hours airborne respirable dust levels analyzed using split plot analysis variance wilcoxon matched pairs test genstat significant lowest ard air found shavings steamed hay single stables straw dry hay abs produced ard air greater air single stables straw haylage produced ard across zones single stables compared abs shavings dry hay dust whereas straw haylage higher ard versus across stable designs using dry hay straw recommended suitable management regime stabled horses elsevier inc rights reserved
despite decades study scholarly consensus emerged regarding whether violent video games contribute youth violence skeptics contend small correlations violent game play violence related outcomes may due factors include wide range possible effects gender mental health social influences current study examines issue large diverse white black hispanic mixed race ethnicity female sample youth eighth eleventh grade models examining video game play violence related outcomes without controls tended return small statistically significant relationships violent games violence related outcomes however predictors included models propensity scores used control underlying propensity choosing allowed play violent video games relationships vanished became inverse reduced trivial effect sizes results offer support conclusion video game violence meaningful predictor youth violence instead support conclusion family social variables influential factors
progress medical science technology drastically improved physicians ability interact patient physical body nevertheless medicine still addresses human body hippocratic point view considering organism processes matter mechanics fluids however interaction cognitive neuroscience bodily self consciousness bsc fundamentally rooted integration multisensory bodily inputs virtual reality haptic technologies robotics giving new meaning classic juvenal latin dictum mens sana corpore sano healthy mind healthy body vision provides basis new research field embodied medicine use advanced technologies altering experience body goal improving health wellbeing research efforts field focused upon external bodily information processed integrated despite important results believe existing bodily illusions still need improved enhance capability effectively correct pathological dysfunctions first follow suggestions provided free energy predictive coding approaches lacked consider peculiar feature human body multisensory integration internal inputs interoceptive proprioceptive vestibular constitute inner body dimension future challenge integration simulation stimulation technologies also able measure modulate internal inner experience body finally also proposed concept sonoception extension approach core idea exploit recent technological advances acoustic field use sound vibrations modify internal inner body experience
objectives study evaluate measurement structure perceived empathic social self efficacy scale amongst individuals serious mental illness smi establish construct validity perceived empathic social self efficacy scale confirmatory factor analysis yielded two factor measurement structure perceived empathic social self efficacy scale positively associated insight social support life satisfaction perceived empathic social self efficacy scale useful measure assess social skills amongst individuals smi rehabilitation counselling
purpose aim paper present research framework green maintainability buildings study makes case development new concept called green maintainability paper also identifies discusses knowledge gap concerning green facilities management integral part green economic environmental social impacts opportunities green maintainability throughout total life cycle facility also highlighted design methodology approach little attention paid maintainability green buildings resulted losses lives due occupational health safety hazards well high operation maintenance costs address issue study conducted literature review determine relevant background knowledge provides conceptual framework aid conceptualizing green maintainability buildings development research framework furtherance concept findings paper finds little research maintainability green buildings studies maintainability green features nonexistent current research study confirms knowledge gap little researched area draws formulation research framework green maintainability buildings ensure green emerging literature green practices methods currently receiving attention academia well building construction practitioners valuably contribute existing theories practices methods concerning building maintainability facilities management originality value study develops novel concept green maintainability integrates maintainability green planning design stage proposed research framework first attempt investigate green maintainability different typologies buildings especially green building technologies
background objective aim study investigate prognostic value four biomarkers ykl chemokine motif ligand ccl surfactant protein patients admitted community acquired pneumonia cap markers studied extensively chronic pulmonary disease acute pulmonary disease prognostic value unknown methods total adult patients hospitalized cap participated randomized controlled trial enrolled biomarker levels measured day admission intensive care unit admission day year long term mortality median follow years interquartile range iqr recorded outcomes results median ykl ccl levels significantly higher levels significantly lower cap patients compared healthy controls significantly higher ykl ccl levels found patients classified pneumonia severity index classes curb score compared patients less severe pneumonia furthermore three markers significant predictors long term mortality multivariate analysis compared reactive protein procalcitonin level admission area curves higher day year long term mortality levels less predictive conclusion ykl ccl levels higher patients severe pneumonia possibly reflecting extent pulmonary inflammation ykl significantly predicts mortality cap
rapid prototyping methodology digital controllers presented paper main application development debugging test microgrid inverter controllers fulfill application requirements systems characterized complex multilayer architectures extending pulse width modulation pwm current control loops global optimization high level communication functions complexity wide variability different layer implementations make digital control mandatory however developing complex digital controllers conventional hardware platforms like digital signal processors dsps even fpgas practical choice paper shows multiplatform control devices software configurable dsp functions programmable logic circuits efficiently combined represent optimal solution field application furthermore paper proposes hardware loop real time simulation effective means developing debugging complex hardware software codesigned controllers case study presented used illustrate different design test phases initial concept numerical simulation final experimental verification
study new non invasive method developed automatically assess lameness broilers aim images broiler chickens recorded vision camera depth sensor walked along test corridor afterwards image processing algorithm applied detect number lying events nol based information distance animal depth sensor camera addition latency lie ltl broilers detected camera later data obtained proposed system compared visually assessed manual labelling data reference method relation measures lameness investigated nol correctly classified proposed vision camera system compared manual labelling using data set collected broiler chickens furthermore results showed significant correlation nol gait score significant negative correlation ltl gait score level broiler chickens strong correlations found nol ltl gait score level broilers one hand results obtained system manual labelling hand results indicate vision monitoring method used tool assessing lameness broiler chickens elsevier rights reserved
current theories suggest brain sole source mental illness however affective disorders major depressive disorder mdd particular may better conceptualized brain body disorders involve peripheral systems well perspective emphasizes embodied multifaceted physiology well suggests afferent signals body may contribute cognitive emotional states review focus evidence preclinical clinical studies suggesting afferent thermosensory signals contribute well depression although thermoregulatory systems traditionally conceptualized serving primarily homeostatic functions increasing evidence suggests neural pathways responsible regulating body temperature may linked closely emotional states previously recognized affective warmth hypothesis human studies indicate increasing physical warmth activates brain circuits associated cognitive affective functions promotes interpersonal warmth prosocial behavior antidepressant effects consistent effects preclinical studies rodents demonstrate physical warmth activates brain serotonergic neurons implicated antidepressant like effects together studies suggest thermosensory pathways interact brain systems control affective function pathways dysregulated affective disorders activating warm thermosensory pathways promotes sense well therapeutic potential treatment affective disorders
touch people associated several outcomes including reduced stress positive mood enhanced feelings closeness positive behavioral change however potential utility touch rarely examined college sample teachers touching students present study used instrumental touch operationalized teaching students take pulse wrist control group touched assessed motivation attitudes toward instructor lecture quiz grades based lecture results indicated touch increased motivation attitudes toward teacher lecture suggest instructors use touch way develop rapport increase student motivation improve attitudes toward instructor course future research evaluate appropriate forms touch possible moderation student instructor gender potential long term benefits using touch classroom
lagrangian hamiltonian formulations electromagnetism reviewed maxwell equations obtained hamiltonian system many electric charges shown three equations obtained hamiltonian namely lorentz force law two maxwell equations obtained well set postulated poisson brackets shown results derived brackets used reconstruct original lagrangian theory aided reasoning based physical concepts
background growing body research assesses population need substance use services however extent survey research incorporates expert versus consumer perspectives service need unknown conducted large international review describe extant research population need substance use services extent incorporates expert consumer perspectives service need critically assess methodological measurement approaches used study consumer defined need examine potential existing research prioritizes consumer perspectives inform substance use service system planning methods systematic searches seven databases identified peer reviewed articles addressing population need substance use services january may empirical studies categorized according source data used derive population estimates service need administrative records biological samples qualitative data quantitative surveys quantitative survey studies categorized whether service need assessed expert consumer perspective studies employing consumer defined need measures received depth quantitative coding describe study designs measurement strategies results almost survey studies used diagnostically oriented measures derived expert perspective assess service need small number survey studies assessed consumer perspectives measured perceived need generic services treatment fewer examining self assessed barriers service use informal help seeking family friends unstandardized measures commonly used little research longitudinal tested hypotheses one study used consumer defined need measure estimate required service system capacity conclusions rhetorical calls including consumer perspectives substance use service system planning belied empirical literature dominated expert driven approaches measuring population need studies addressing consumer defined need substance use services conceptually underdeveloped exhibit methodological measurement weaknesses scholarship needed integrate multidisciplinary perspectives literature fully realize promise incorporating consumer perspectives substance use service system planning
affect dysregulation characterized heightened reactivity strong emotions difficulty calming upset mood instability phenomenon widely examined older foster youth yet may avenue improve behavior functioning young adulthood study examines two dimensions adaffect skills deficits affect instabilityin sample year old foster youth assessing relationship dimension risk factors behavioral health service use age predictors functional outcomes age found level among older foster youth similar clinical sample associated history physical abuse depression attention deficit hyperactivity disorder disruptive behavioral disorders higher levels affect skills deficits associated use intensive types services psychiatric hospitalization residential treatment psychiatric medications affect instability higher levels affect skills deficits negatively related graduating high school positively related arrested especially affect skills deficits promising target inclusion interventions support older foster youth mental health problems
background although judo throwing techniques considered injurious attacker repetition techniques might cause repetitive strain type injuries goal study knowledge degrees flexion extension abduction adduction main locomotive joints performing employed throwing techniques high level competition material methods two world class judoists supervision elite japanese expert performed seoi nage uchi mata osoto gari ouchi gari kouchi gari analysed using three dimensional technology results data performance throws obtained expert respectively similar results indicate systematic repetition seoi nage uchi mata soto gari produce shoulder tendon pathologies longterm seoi nage uchi mata practice might generate epicondylitis judokas suffered anterior cruciate ligament injuries must careful executing techniques demand explosive knee extension seoi nage great resistance judokas exposed overuse injuries perform ouchigari kouchi gari throws conclusions systematic practice employed judo throwing techniques high level judo cause injuries overuse upper body joints shoulder elbow nevertheless lower body joints knee ankle seem risk injury overuse
urban living environment becoming complex road condition becoming worse heavy traffic increase traffic accidents high ratio empty vehicles increases cost transportation wastes time vehicle movement highly populated countries like india accidents people lose lives due unavailability proper medical facilities right time project senses accident vehicle intimates pre programmed numbers like family members rider ambulance police station nearest hospital etc gsm technology used send position vehicle sms numbers also position vehicle obtained companies want keep track vehicles equipment keep track vehicle periodically sending sms position vehicle sent gsm modem sms user project electronic device installed vehicle helmet enable hospital ambulance police station relative driver track met accident get immediate hospitalization embedded system used tracking positioning vehicle met accident using global positioning system gps global system mobile communication gsm design continuously monitor moving vehicle along rider wearing helmet report status demand send rescue message met accident renesas microcontroller interfaced serially gsm modem gps receiver gsm modem used send position latitude longitude rider gps modem continuously give data latitude longitude indicating position rider data sent mobile numbers
article considers problems developing green building technologies standards russian construction industry using nanotechnology products using roofing example buildings increasingly incorporate new construction materials include use sustainable nanotechnology products creating new conditions improving efficiency safety generally thereby providing comfortable built environment future generations nanotechnology construction performs complex tasks providing competitive advantage comparison conventional technologies facility managers thereby inherit buildings constructed high quality building materials operating energy efficient engineering equipment published elsevier ltd
human lasiodiplodia theobromae infection reported frequently report first case invasive theobromae nasal neck infection year old male visited hospital anemia general weakness showed pancytopenia bone marrow examination revealed markedly decreased hematopoietic cells patient presumed iatrogenic aplastic anemia due mushroom toxicity began treatment multiple organ infections broad spectrum antibiotics antifungal agents hospitalization complained nasal obstruction left neck lymph node enlargement mass like lesion observed nasal mass biopsy performed mass identified fungal ball underwent surgical excision nasal mass neck lymph node pathologic examination indicated invasive fungal infection lymph node revealed chronic granulomatous inflammation fungal infection rrna sequencing revealed sequence shared identity theobromae nasal mass fungus identified internal transcribed spacer region sequencing pathologic paraffin sections obtained sequence corresponded lasiodiplodia macrophoma sequence corresponded neck discharge sequence results hence patient diagnosed invasive fungal sinusitis neck lymph node involvement caused theobromae knowledge first report theobromae infection korea first report invasive theobromae fungal sinusitis literature include precise evaluations additional novel fungal species possible candidates
traditional treatments medication surgery tremor management parkinson disease shown varying effectiveness carry risk significant side effects recent research development wearable tremor suppression technology shown promising third solution tremor management paper presents design novel multi channel mechatronic splitter mms use wearable tremor suppression devices mechatronic system allows single drive motor support multiple independent outputs operation speed direction mms controlled motor low power characteristic may provide promising approach achieving prolonged operating life wearable devices furthermore size mms scaled proportionally according different applications optimal performance paper describes design modeling implementation characterization mms weight mms prototype maximum output speed rpm maximum continuous torque addition recorded tremor motion along voluntary movement individuals parkinson disease used validate performance mms mms controlled suppress tremor motion following voluntary movement subject average rms error voluntary motion tracking achieved dynamic tremor suppression test elsevier rights reserved
unmanned aerial vehicles uav gaining popularity due application military private public sector especially attractive fields human operator required light weight uavs desirable better performance terms shorter take range longer flight endurance however light weight structures complex inner features hard fabricate using conventional manufacturing methods ability print complex inner structures directly without need mould gives additive manufacturing edge conventional manufacturing recent development composite multi material printing opens new possibilities printing lightweight structures novel platforms like flapping wings ease paper explores impact additive manufacturing aerodynamics structures materials used uav review discuss state art technologies uavs innovations materials structures advantages limitations role additive manufacturing improve performance uavs smart material actuators multi functional structures also discussed elsevier masson sas rights reserved
two populations found exhibit delays theory mind tom deaf children hearing parents children autism spectrum disorder asd deaf children exposed sign birth deaf parents however show delay suggesting early language exposure key tom development sign languages also present frequent opportunities visual perspective taking vpt leading question whether sign exposure could benefit children asd present first study children asd exposed sign birth deaf parents seventeen native signing children confirmed asd diagnosis chronological mental age matched control group typically developing native signing deaf children tested american sign language asl comprehension two minimally verbal social cognition tasks tom vpt one spatial cognition task mental rotation children outperformed children asd asl comprehension tom vpt mental rotation language strongly correlated tom vpt mental rotation native exposure sign thus insufficient overcome language social impairments implicated asd contrary hypothesis sign could provide scaffold tom skills find signing children asd unable access language gain potential benefit sign might confer results support strong link development social cognition language regardless modality asd children autism res international society autism research wiley periodicals inc
article describes summer institute global mental health psychosocial support brief immersion training program mental health health allied professionals work populations endured severe adversities trauma domestic political violence extreme poverty armed conflict epidemics natural disasters course taught participants apply collaborative contextually sensitive approaches enhance social connectedness resilience families communities organizations article presents core training principles vignettes illustrate engaging interventions must work context strong supportive organization appreciate complexity systems engaging open possibilities healing transformation program utilized combination didactic presentations hands interactive exercises case studies experiential approaches organizational team building staff stress management
depression one world leading global burdens leading various comorbidities lithium mainstay treatment depression still considered gold standard treatment similar lithium another agent agmatine also central protective role depression since agmatine lithium modulate various effects interaction nmda receptor therefore current study aimed investigate synergistic antidepressant like effect agmatine lithium mouse force swimming test also know whether effect due interaction nmda receptor present study found potent dose lithium administered significantly decreased immobility time also subeffective dose agmatine coadministered subeffective dose lithium potentiated antidepressant like effect subeffective dose lithium involvement nmda receptor effect administered nmda receptor antagonist combination subeffective dose lithium agmatine significant antidepressant like effect observed furthermore subeffective dose nmda given inhibited synergistic effect agmatine lithium hence finding demonstrate agmatine synergistic effect lithium mediated nmda receptor pathway elsevier masson sas rights reserved
assessment economic potential wind electricity critical importance wind power development china based wind resource data geological assumptions paper calculates economic potential china onshore wind electricity furthermore builds econometric model update net present value model based survey sample various wind farms results show economic potential china onshore wind electricity pwh per year feed tariff price yuan cents per kilowatt hour elsevier rights reserved
atopic dermatitis characterized interplay skin barrier defects immune system skin microbiome causes patients risk infectious complications article reviews pathogenesis atopic dermatitis mechanisms patients risk infection bacterial viral fungal pathogens although complications may managed acutely prevention secondary infections depends multipronged approach maintenance skin integrity control flares microbial pathogens
background marijuana legalized medical use states recreational use however effects marijuana use thyroid function autoimmunity unknown methods performed cross sectional analysis data national health nutrition examination survey nhanes conducted assess effects marijuana thyroid function autoimmunity users included adults ages years responded questions related marijuana use laboratory results related thyroid parameters subjects categorized nonusers never used past users used prior days ago recent users used within last days using nhanes normative cut offs thyroid parameters compared recent users nonusers past users calculated odds ratios relative rate clinically significant thyroid dysfunction groups multivariate logistic regression performed control confounders results fifty four percent subjects reported lifetime cannabis use using recently univariate regression analysis showed recent marijuana users significantly lower frequency elevated thyrotropin tsh positive anti thyroperoxidase antibody tpoab versus nonusers past users controlling confounders recent marijuana use remained independent predictor tsh odds ratio negative tpoab conclusion recent marijuana use associated thyroid dysfunction significantly associated lower levels tsh
since previous studies showed anti citrullinated protein antibodies acpa induce osteoclasts differentiation activation even arthritis onset aim study determine whether acpa positivity associated lower bone mineral density bmd baseline visit register early arthritis patients study population comprised patients females clinic median disease duration months median age years acpa positive fulfilling criteria rheumatoid arthritis bmd measured using dual ray absorptiometry lumbar spine hip metacarpophalangeal mcp joints non dominant hand evaluate systemic juxta articular bone mass acpa titers determined enzyme immunoassay effect acpa bmd analyzed using multivariable analysis based generalized linear models adjusted various confounders acpa positive patients showed lower bone mass lumbar spine hip differences observed mcp joints compared acpa negative patients however acpa positive patients displayed higher disease activity disability acpa negative patients adjustment gender age body mass index bone related variables presence acpa remained significantly associated lower bmd lumbar spine femoral neck hip mcp joints disease activity associated baseline bone mass data reinforce previous preclinical findings suggesting systemic bone loss detected initial phases early acpa positive arthritis independent inflammatory status therefore could mediated acpa
quality assessment construction project schedule challenging task project stakeholders little research work addressed quality schedules though good project schedule considered key factors project success development reliable easy perform construction schedule quality assessment procedure seems challenging task since schedule health assessment construction project strictly related process requirements used rule starting point framework obtaining improved understanding quality construction schedules safety space structure meaning planned process provide safe working environment construction workers sufficient space perform construction activities required sequence construction operations project phases aim study implement schedule quality assessment method takes account rule construction process requirements successfully integrated schedule health assessment method facilitate implementation control flow line chart needed thus schedule tool becomes new requirement construction schedule quality control authors published elsevier
achieving sustainable energy systems involves complex decision making processes article addresses combination life cycle approaches data envelopment analysis dea sustainability assessment energy systems literature survey multi criteria decision analysis mcda tools sustainability assessment energy systems commonly used criteria data sources tools identified moreover review dea approaches available date performed order check convenience assess energy systems terms sustainability sense central focus article explore elucidate potentials combined approaches within sustainability oriented mcda field energy potentials mainly associated usefulness sustainability benchmarks decision makers wide availability dea models life cycle approaches given growing role mcda tools energy scenario analysis innovative trends found dea novel methodological framework proposed enriched energy systems modelling endogenous integration life cycle indicators ranking benchmarking energy scenarios according sustainability criteria using dynamic dea dea concept emerges promising methodology evaluate rank prospective scenarios energy planning thus facilitating decision making processes towards sustainable energy future elsevier ltd rights reserved
objectives emotional processing abnormalities implicated bipolar disorder studies typically small uncontrolled facial expression recognition explored large naturalistically recruited cohort patients methods patients completed facial expression recognition task effects current medication together influence current mood state diagnostic subtype assessed whilst controlling effects demographic variables results patients currently receiving treatment lithium demonstrated significantly poorer accuracy recognising angry faces effect held monotherapy sub analysis comparing participants lithium medication free accuracy recognising angry faces also lower amongst participants currently taking dopamine antagonists antipsychotics higher levels current depressive symptoms linked poorer accuracy identifying happy faces conclusion use lithium possibly dopamine antagonists may associated reduced processing anger cues findings support existence mood congruent negative biases associated depressive symptoms observational cohort studies provide opportunities explore substantial effects demographic psychometric clinical variables cognitive performance emotional processing
paper bask transconductor composed channel channel metal oxide semiconductor field effect transistors mosfets utilization low voltage first order voltage mode pass filter apf design studied initial filter design general structure employing single transconductor two admittances proposed choosing passive components considering real behavior mosfets parasitic capacitances output resistances six specific cases apf design discussed spice simulations using ibm level sige cmos process bsimv parameters supply voltages included support theoretical results selected solution designed pole frequency mhz consumes power
objective investigate common complications microsurgical treatment large intracranial vestibular schwannoma via suboccipital retrosigmoid approach propose strategies minimizing complications methods selected patients large unilateral collected database underwent microsurgical resection initial treatment histopathologically confirmed tumors larger chi defined large results total patients included gross total tumor resection achieved patients mortality rate facial nerve preserved anatomically cases functional valuation facial nerve according postoperative house brackmann scale showed patients grades cases grade iii patients grade main short term postoperative complication included new hearing loss american institute otolaryngology head neck surgery grade cases disequilibrium cases labial herpes cases meningitis lower cranial nerve deficit cases follow data available patients long term complications include hearing loss american institute otolaryngology head neck surgery grade permanent facial paralysis facial numbness tinnitus chronic headache taste disturbance conclusions key factors reducing surgical complications include careful assessment functions acoustic facial nerves well thorough understanding anatomy via retrosigmoid approach operation skillful microsurgical technique monitoring multiple cranial nerves resection
importance watermarking digital databases increased leaps bounds due high vulnerability digital assets piracy attempts traverse internet deter piracy propose robust watermarking scheme relational databases containing categorical data resolves ownership issues propose three level security strategy firstly watermark made secure using playfair cryptographic algorithm secondly database securely partitioned using primary key independent hash partitioning technique step virtually reorders tuples embedding thirdly entail secret key based embedding process ensure security linear feedback shift registers implemented generate pseudorandom numbers selects different watermark bit index partition process embedding produce distortion database hence suitable databases categorical attributes containing sensitive information tolerate perturbations watermark bit embedded multiple times different partitions makes scheme highly robust various attacks technique proved experimentally theoretical analysis extremely robust experimental results show per cent resilient subset addition attack per cent resilient subset alteration attack per cent resilient tuple deletion attack prove analytically resilience proposed technique invertibility additive attacks
smart materials structures international frontier field current development engineering science representative soft smart materials include electroactive polymers eaps shape memory polymers smps etc new kind smart deformation material smps wide range applications field smart material structures due controllable shape memory effects deformation mechanism smp material basis applications paper proposed useful thermoviscoelastic constitutive model considering thermal expansion structure relaxation viscoelastic properties epoxy smp material verify applicability model various experiments isothermal uniaxial tensile tests carried simulated results showed constitutive model could nicely predict mechanical behavior epoxy smp proposed constitutive model useful design smps structures
introduction empathy sub process social cognition defined capacity understand share another person thoughts wishes feelings crucial many forms adaptive social interaction contextual flexible multidimensional phenomenon related different neuronal networks processes aims assess empathy sample subjects diagnosed conditions belonging category severe mental disorders treatment psychosocial rehabilitation programme subjects methods sample consisted persons severe mental disorders receiving treatment consisting psychosocial rehabilitation programme healthy controls battery tests including empathy quotient reading mind eyes test interpersonal reactivity index administered subject results reading mind eyes test experimental group scored significantly lower control group statistically significant differences found variables conclusions persons severe mental disorder display generalised deficit empathy however difficulty comes recognising emotional states looking suggests process information faces different way subjects normal population
fiix prothrombin time fiix differs traditional affected reduced factor randomized controlled fiix trial patients warfarin monitored fiix fiix warfarin patients fewer thromboembolisms similar major bleeding stable anticoagulation patients monitored warfarin patients current fiix trial report analyzed reduced anticoagulation variability fiix monitoring reflected patients bleeding data randomized patients used analyzed groups anticoagulation intensity time within target range ttr international normalized ratio inr variability variance growth rate vgr dose adjustment frequency assessed parameters associated clinically relevant vascular events crve clinically relevant non ttr highest fiix warfarin patients without crve median iqr lowest warfarin patients vgr lowest fiix warfarin patients without crve median vgr highest warfarin patients mean annual dose adjustment frequency lowest fiix warfarin patients mean without crve mean highest warfarin patients frequent dose changes predicted study arms compared patients monitored high anticoagulation stability fiix warfarin patients coincided low rate bleeding high variability irrespective monitoring method thus although improvements needed reduce bleeding stabilization anticoagulation fiix monitoring associates reduced
conventional quantitative computed tomography qct uses phantom scanned simultaneously anatomical region interest newly developed method called asynchronous qct require phantom present patient scan allows inclusion computer tomography scans performed without calibration standard different clinical context bone densitometry example screening context present study asynchronous conventional quantitative computed tomographies compared specifically short term precision phantom induced bias methodical equivalence asynchronous conventional methods interobserver variability investigated ten phantom scans served investigation short term precision prospective dataset study participants years mean years acquired clinical sites trabecular regions spine well cortical trabecular regions hip femoral neck trochanter intertrochanter shaft analyzed respect presence absence phantom regard synchronous asynchronous calibration methods regarding precision variations mean areal volumetric densities lower asynchronous method conventional method presence phantom resulted bias choice asynchronously synchronously calibrated analysis resulted bias spine statistically clinically significant total hip statistically clinically significantly different bone density values techniques correlated highly one another regions investigated interobserver variability trained observers showed difference spine differences less equal hip regarded clinically nonsignificant summary asynchronously calibrated qct provides results comparable established synchronously calibrated qct
despite growing interest intellectual humility intellectual arrogance adequate measurement remains challenging issue paper presents pair studies compare two strategies self assessments relational measures group consensus study unacquainted participants provided round robin judgments following set collaborative tasks social relations analysis revealed consensus either construct making relational measure untenable however round robin design following months cooperative course work study produced consensus constructs self reported studies positively associated self enhancement despite construct definitional association accurate self appraisals whereas relational studies reveal key ways personal relational assessments differ elsevier inc rights reserved
tree species information essential forest research management purposes turn require approaches accurate precise classification tree species one remote sensing technology terrestrial laser scanning tls proved capable characterizing detailed tree structures tree stem geometry tls differentiate broad needle leaves answer positive tls data used classification taxonomic tree groups directly examining differences leaf morphology analysis proposed assess tls represented broad needle leaf structures followed bayes classifier perform classification tests indicated proposed method basically implement task overall accuracy study indicates way implementing classification two major broad needle leaf taxonomies measured tls accordance literal definitions manifests potential extending tls applications forestry society photo optical instrumentation engineers spie
modern data collection analysis pipelines often involve sophisticated mix applications written general purpose specialized programming languages many formats commonly used import export data different programs systems csv json verbose inefficient type safe tied specific programming language protocol buffers popular method serializing structured data applications remaining independent programming languages operating systems unique combination features performance maturity seems particularly well suited data driven applications numerical computing rprotobuf package provides complete interface protocol buffers environment statistical computing paper outlines general class data serialization requirements statistical computing describes implementation rprotobuf package illustrates use example applications large scale data collection pipelines web services
background atopic dermatitis chronic relapsing pruritic inflammatory skin disease whose management remains unclear non dermatologists study aimed assess knowledge attitudes practices kap medical staff regarding yaounde cameroon methods cross sectional study conducted january april health facilities located yaounde capital city cameroon medical staff provided consent included study score established kap categories subsequently grouped classes considering score respectively results enrolled medical personnel females overall level knowledge moderate allergy main cause stated participants personnel cited genetic cause asthma mentioned associated pathology regarding attitudes majority thought equally common among black caucasian populations participants believed evolution favorable appropriate medical treatment prescribed attitudes considered wrong similarly general level practice inadequate conclusion levels knowledge attitudes practices medical staff regarding poor implying management condition non optimal setting
transport nano scale particles become increasingly important knowledge base available limited study aims bridge knowledge gap nano micro scales pneumatic conveying key parameter minimum pickup velocity minimum fluid velocity required initiate motion particle originally rest values nine alumina particles particle diameters ranging determined using weight loss method compared established pickup zones analogous geldart groups results indicated varied non monotonically increasing thus revealing missing link nano micro scales intermediate particle diameters surprisingly agree pickup zone zone iii analogous geldart group inadequate nano scale particles new boundaries new zone proposed american institute chemical engineers aiche
study compares lifecycle costs greenhouse gas ghg emissions electric vehicle ownership popular similar cars hawaii focuses interaction costs hawaii rapid solar uptake using scenario planning approach future fuel electricity prices evs include battery electric vehicles bevs plug hybrid electric vehicles phevs find total cost ownership tco evs tends higher internal combustion engine vehicle icev hybrid electric vehicle hev counterparts accounting federal tax credit however evs become relatively cost effective moreover access residential solar makes evs quite attractive layering federal subsidy solar charging makes full lifecycle cost nissan leaf less expensive next lowest cost vehicle toyota corolla mile lifetime nonetheless may early tout evs hawaii ghg abatement strategy based today mix electricity generation best performing phev bev emit mtco respectively lifetime best performing hev however many evs become par high performing hevs considering hawaii adoption aggressive renewable energy goals electric sector electric sector meets renewable portfolio standard rps target renewables low carbon sources like wind solar toyota plug prius nissan leaf toyota prius become comparable terms ghg impacts integrating residential solar even weekend charging makes evs outperform toyota prius regards lifetime ghg emissions addition level charging renewable sources electricity bevs outperform phevs environmental benefits evs depend critically electricity system derive power given wide variation mix electricity generation throughout even throughout day adoption intermittent sources renewable energy additional policy tools needed match places times high levels renewables charging particular suggest regional approach subsidies account emissions intensity electricity systems may appropriate current blunt federal tax credit adoption time use pricing accounts ghg impacts may critical supporting evs ghg abatement tool currently however evs relatively costly ghg abatement strategy elsevier ltd rights reserved
broadband broad angle radar cross sectional rcs reduction measure applicable planar surfaces proposed novel structure contains several layers randomly displaced metal patches layers spaced quarter wavelength specular reflection normal incidence suppressed phase cancellation technique reduction bandwidth broadened setting layer surface area ratio based binomial coefficients structure contains absorbent material metal surfaces divided small patches displaced randomly avoid reflection peaks beyond boresight direction rcs reduction effect validated via measurements far field antenna range parametric studies detailed discussions technique conducted using simulation results computed full wave numerical tools include specular reflection also contributions higher order scattering mechanisms proposed structure applied planar target surfaces potential incorporate lossy dielectric loadings reduce structure thickness suppress scatterings
fuzzy clustering useful segmentation tool widely used many applications real life problems pattern recognition recommender systems forecasting etc fuzzy clustering algorithm picture fuzzy set pfs advanced fuzzy clustering algorithm constructed basis picture fuzzy set appearance three membership degrees namely positive neutral refusal degrees combined within entropy component objective function handle problem incomplete modeling fuzzy clustering disadvantage pfs capability handle complex data include mix data type categorical numerical data distinct structured data paper propose novel picture fuzzy clustering algorithm complex data called pfca deals mix data type distinct data structures idea method modification pfs using new measurement categorical attributes multiple centers one cluster evolutionary strategy particle swarm optimization experiments indicate proposed algorithm results better clustering quality others clustering validity indices elsevier ltd rights reserved
matter environmental concern prioritization integrated globally used green building rating systems fundamental issue since determines performance structure development reflected certain nationally developed certification systems used globally without subjected adjustments respect local geographical cultural economic social parameters may lead situation results evaluation may reflect reality region site construction main objective paper examine underline problems regarding issue weighting environmental concerns leadership energy environmental design leed certification system originated globally used assessment tool methodology study consists analysis approach leed new construction major renovations scheme version leed building design construction scheme version leed case studies regional priority credits rpcs set leed four countries canada turkey china egypt criticized respect countries local conditions iii analysis approaches major environmental assessment tools namely breeam sbtool casbee green star comparison approach leed regarding main issue paper work shows even latest version leed still displays inadequacies inconsistencies aspect environmental concern prioritization yet managed incorporate system sensitive issue paper outlines differences similarities approaches aforementioned major environmental assessment tools respect issue concern factors integrated future versions leed elsevier ltd rights reserved
paper part multi disciplinary research application decentralized site water treatment system egypt use agriculture producing safe fish animal proteins project aimed investigate environmental impact implementing sewage water treatment using effluent site decentralized japanese johkasou system agriculture producing fish protein aim establish system egypt strengthen sanitary conditions water resources present study impact sewage pollution fish farms fayyum port said dakahlia governorates egypt carried water fish oreochromis niloticus mugil cephalus samples collected private fish farms localities bacteriological chemical examination water samples revealed existence coliforms many bacterial species significant human health hazards chemical parameters water showed marked deviation normal levels examination fish flesh specimens indicated contamination streptococcus staphylococcus salmonella examined localities bacterial isolates human health importance morganella morganii pseudomonas cepacia enterococcos durans identified parasitological examination revealed presence encysted metacercariae emc diplostomatidae prohemistomatidae heterphyidae moreover two protozoan parasites mxyoboulus tilapiae ichthyophthirius multifilis also recorded histopathological examination revealed mild tissue reaction case bacterial infection severe pathological lesions different organs case emc infection lamellar hyperplasia mononuclear cell infiltration branchial tissue common findings skeletal muscles atrophy muscle fibres myolysis myophagia detected elsevier ltd rights reserved
rectangular dissections commonly used tabular forms spreadsheets raster data computer graphics forth need processing cells data represented rectangular dissections paper deal data structures algorithms rectangular dissections raster data heterogeneous parts particular would like introduce algorithm subdivide homogenize rectangular dissections heterogeneous parts represented octgrids
electronic lottery protocol proposed achieve series functional properties including correctness fairness randomness traceability unforgeability robustness practicability efficiency however weakness destroys fairness randomness often ignored least players collude control generation specific winning result obtain prize using oblivious transfer based elliptic curve cryptography ecc paper presents improved lottery protocol inherits previous merits also resists collusion attack participants fairness randomness really achieved furthermore improved protocol efficient previous version due feature ecc
despite numerous studies parenting stress suggesting negative influences parent child interactions children development majority studies focus mothers parenting stress little acknowledgement fathers using data national early head start research evaluation project study examined effects fathers parenting stress toddlerhood children language cognitive outcomes children years old whether effects fathers parenting stress children language cognitive development vary child gender results mixed linear models showed fathers parenting stress predicted children lower cognitive scores gender differences effects fathers parenting stress children cognitive outcomes language domain boys girls found susceptible effects fathers parenting stress findings indicated fathers addition mothers included early parenting research interventions copyright john wiley sons ltd
sexual harassment coercion mainly considered sex difference perspective traditional social science theories explained harassment male dominance females evolutionary perspective suggested sex differences desire sex better explanation study attempts address individual differences associated harassment evolutionary perspective considering previous research found links sociosexual orientation inventory sot harassment consider whether association replicated large representative sample high school students highly egalitarian culture expanding previous studies mainly focused male perpetrators female victims also examine females males perpetrators victims believe unrestricted sociosexuality motivates people test whether others interested short term sexual relations ways sometimes might defined harassment furthermore unrestricted individuals signal sociosexual orientation desire individuals react signals sexual advances attract much sexual advances individuals restricted sociosexual orientations especially unrestricted members opposite sex less unconscious signaling thus makes exploitable harassable find sot predictor sexual harassment coercion among high school students paper concludes expected unrestricted sociosexuality predicts perpetrator victim sex opposite sex harassment elsevier inc rights reserved
objective study differences imaging utilization downstream initial emergency department ultrasound examinations interpreted radiologists versus nonradiologists methods using medicare research identifiable files identified episodes place service emergency room hospital patient also underwent ultrasound examination determined whether initial ultrasound interpreted radiologist nonradiologist summed additional imaging events occurring within days initial ultrasound year study window calculated mean number downstream imaging procedures specialty group results ultrasound events interpreted radiologists nonradiologists across study years patients undergoing ultrasound examinations interpreted nonradiologists underwent additional diagnostic imaging studies days respectively compared initial ultrasound examination interpreted radiologist volume downstream imaging radiologists non radiologists significantly decreased year resulting fewer imaging examinations days ultrasound event despite decline differences downstream imaging radiologists nonradiologists persisted rime conclusion downstream imaging initial ultrasound significantly reduced ultrasound examination interpreted radiologist rather nonradiologist
three persistent common problems satellite ground control software obsolescence lack desired features flexibilities endless software bug fixing obsolescence problem occurs computer ground equipment hardware become obsolete usually one third satellite mission lifetime software needs updated accommodate changes hardware side requiring significant work satellite operators test verify validate software updates trying help solve problems proposed object process methodology model guidelines developing satellite ground control software system makes use database driven application concepts object process orientation modularity new proposed framework instead coding software function separately common base functions coded combining various ways provide different required functions formation combination base functions governed main code definitions database parameters design principles make sure new software framework would provide satellite operators flexibility create new features enable software developer find bugs quicker fix effectively copyright john wiley sons ltd
article explores commonly discussed theories violent video game effects social learning mood management catharsis hypotheses experimental study carried examine violent video game effects study young adults given frustration task randomized play game nonviolent game violent game good versus evil theme playing good character taking evil violent game played bad guy results indicated randomized video game play effect aggressive behavior real life violent video game playing history however predictive decreased hostile feelings decreased depression following frustration task results support link violent video games aggressive behavior suggest violent games reduce depression hostile feelings players mood management
despite continued interest use mixed methods limited attention paid literature generic lessons could gained mixing methods practice many organisational problems demand use mixed method approach thus recognising sharing lessons could prove beneficial practitioners researchers paper reports depth evaluation case study involving risk identification quantification northern isles new energy solutions nines project sought trial plan new energy system intervention involved mixed method approach client feedback efficacy approach sought evaluation reported paper carried using set themes taken literature seeks highlight transferable lessons set lessons emerge presented along implications general modelling practice specific situation mixing methods paper concludes discussing implications work directions future work interest practitioners researchers interested mixed method work elsevier ltd rights reserved
propose new model social influence occur spontaneously absence typically assumed motives assume perceivers routinely construct representations people experiences responses beliefs attitudes emotions behaviors observing others responses simulating responses unobserved others like representations made accessible priming representations may influence process generates perceivers responses without intention awareness especially strong social connection describe evidence basic properties important moderators process distinguish mechanisms informational normative social identity influence model offers new perspectives role others values producing cultural differences persistence power stereotypes adaptive reasons influenced others responses impact others views self
security nowadays indispensable requirement software systems traditional software engineering processes focus primarily business requirements leaving security afterthought addressed via generic patched defensive mechanisms approach insufficient software systems need security functionality engineered within similar fashion ordinary business functional requirements functional security requirements need elicited analyzed specified validated early stages development life cycle functional security requirements properly validated risk developing system insecure deeming unusable acceptance testing effective technique validate requirements however hoc approach develop acceptance tests suffer omission important tests paper presents systematic approach develop executable acceptance tests specifically geared model based secure software engineering processes approach utilizes early stage artifacts namely misuse case domain models robustness diagrams feasibility proposed approach demonstrated applying real world system results show comprehensive set security acceptance tests developed based upon misuse case models early stage validation functional security requirements
motivational interviewing popular evidence based method support health behavior change examined evaluations years interprofessional workshops identify trends trainees related knowledge attitude behavior trainees participated continuing education workshops team completed validated posttraining questionnaire participants female white years practice worked pediatric adult care urban rural locations inpatient outpatient nonhealth settings largest groups nurses allied health professionals health educators case managers trainees professional diversity increased time average age years practice decreased percentage prior training increased practitioners telehealth nonhealth settings lower scores overall outcomes varied significantly professional discipline mental health professionals case managers health educators nurses higher scores outcome variables nonhealth professionals years clinical experience predicted consistent attitude prior training demographic variables training process variations consistent effects although many trainees already received training outcome measures showed room improvement presents continued opportunities interprofessional education
suggested people attend others actions service forming impressions underlying dispositions follows considering others morally relevant actions social perceivers responsive accompanying cues help illuminate actors underlying moral character article examines one relevant cue characterize decision process speed decision made two experiments show actors make immoral decision quickly slowly evaluated negatively contrast actors arrive moral decision quickly slowly receive particularly positive moral character evaluations quick decisions carry signal value assumed reflect certainty decision experiments turn signals unambiguous motives drove behavior experiment turn explains polarized moral character evaluations implications moral psychology law discussed
work electromagnetic characterization composite materials reinforced carbon metallic nanoparticles presented particular electric permittivity magnetic permeability function frequency used evaluate electromagnetic absorption capability nanocomposites aim study possible applications advanced coaling able tune electromagnetic reflectivity satellite surfaces specific frequency ranges special way surfaces reason could exposed antenna radiation pattern fact interference caused spurious electromagnetic multipath due good electric conductive satellite surface components could turn affect main radiation lobe tlc telemetry antennas thus modifying main propagation directions finally increasing microwave channel pathloss work reports analysis different nanostructured materials ghz frequency range employed nanopowders carbon nanotubes cobalt argent titanium nickel zinc copper iron boron bismuth hafnium different weight percentages versus hosting polymeric matrix materials classified function electromagnetic losses capability taking account electric magnetic properties possibility design multi layered structures optimized provide specific microwave response finally analyzed aid swam intelligence algorithm novel technique general interesting metrological purpose remote sensing purposes effectively used aerospace field frequency selective materials design order reduce aircraft spacecraft radar observability certain frequencies
prior studies schizophrenia patients described reduced ability discriminate correct false memories terms confidence compared control groups metamemory bias associated emergence maintenance delusions relation neuropsychological performance clinical dimensions incompletely understood cross sectional study metamemory functioning explored schizophrenia patients healthy controls metamemory assessed using verbal recognition task combined retrospective confidence level ratings associations metamemory performance six neuropsychological domains executive functioning problem solving speed processing working memory verbal visual learning attention vigilance psychopathological measures analyzed results revealed significantly smaller discrepancy confidence ratings correct incorrect recognitions patient group furthermore patients showed significantly lower recognition accuracy metamemory task marked deficits neuropsychological domains across participants metamemory performance significantly correlated executive functioning working memory associations delusions found data confirms prior findings metamemory biases schizophrenia selective neuropsychological abilities seem modulating factors metamemory functioning longitudinal studies risk mental state first episode patients needed reveal causal interrelations elsevier ireland ltd rights reserved
article proposes analysis spanish modern literature specifically excerpts novels almudena grandes broaden pragmatic understanding students spanish foreign language non immersion context presents series activities students level exploring cultural aspects defining pragmatic meanings include elements verbal nonverbal communication beyond use voice kinesthetic proxemics use space
background abortion iran like islamic countries severely restricted except exceptions however women unwanted mistimed pregnancy seeking abortion objectives study aimed compare contraceptive use related factors among repeat first time induced abortion seekers iran patients methods cross sectional study married women age range years seeking abortion services either hospital private office maku city northwest iran selected convenience sampling december march subjects asked contraceptive methods used three months current pregnancy use emergency contraception forced sex women mentioned reasons except completing family size applying abortion excluded analysis characteristics women examined using chi square test test mann whitney test used compare contraceptive methods regularity contraceptive use repeat first time abortion seekers respectively results repeat abortion seekers first time abortion seekers using male methods withdrawal condom utilization intrauterine device birth control higher among women seeking repeat abortion first time abortion seekers pill users repeat abortion seeking group missed three pills per month three times three months contraception repeat abortion seekers used condom regularly first time abortion seekers forced sex prevalent abortion seekers used male method conclusions using male methods prevalent abortion seeker women increased focus needed training regular use pills using emergency contraception couples first time abortion seekers moreover information role forced sex might efficacious decreasing illegally induced repeat abortion couples use condom withdrawal methods
bilinear oscillator spring mass system spring different stiffnesses tension compression analyze behavior bilinear oscillator constant preload assuming spring lower stiffness tension compression formulate conditions existence asymptotics low stiffness ratios conditions bilinear oscillator approximated impact oscillator oscillator zero stiffness ratio preload asymptotics damping stiff compressive part modeled introduction restitution coefficient found use impact oscillator asymptotics low stiffness ratios possible sufficiently small preloads also determined values restitution coefficient simulate given damping high stiffness region relation damping restitution coefficient found independent magnitude preload elsevier ltd rights reserved
schadenfreude occurs people feel pleasure others misfortunes previous research suggested individuals feel malicious pleasure misfortune befalls social targets perceived highly competent lacking human warmth two experiments explored whether two components warmth sociability morality distinct roles driving schadenfreude study compared competent immoral individual competent unsociable person found people felt schadenfreude misfortune befell individual lacking morality study confirmed primary role morality driving schadenfreude manipulating morality sociability also competence moreover experiments showed social targets lacking moral qualities elicited higher levels schadenfreude misfortunes perceived deserved overall findings suggest morality primary role basic dimensions person perception sociability competence driving schadenfreude
recently two span called single pylon suspension bridges due constructing structure widely applied reduction deformation seems main problem behaviour design bridges deformation suspension bridges mainly determined cable kinematic displacements caused temporary loadings rather elastic deformations known methods stabilization initial form suspension bridges suitable single pylon bridges employment called rigid cables increase general stiffness suspension bridge appears one innovative methods stabilizing initial form single pylon suspension bridges rigid cables designed standard steel profiles compared common ones made spiral parallel wires resistant corrosion moreover construction joints terms fabrication installation simpler form however calculation methods single pylon suspension bridges rigid cables sufficiently prepared single publications analysis behaviour one three span suspension bridges rigid cables available far paper presents analytical expressions calculate displacements internal forces suspension bridges rigid cables thus assessing sequence cable installation also paper describes sequence iterative calculation
ferulic acid hydroxy methoxycinnamic acid phytochemical constituent polyphenols group commonly found whole grains spinach parsley grapes rhubarb widely applied skin care formulations photoprotective agent delayer cutaneous photoaging processes work aims establish protocol development cosmetic formulations using thermoanalytical techniques dtg dsc pearson correlation ftir data order evaluate compatibility ferulic acid excipients used skin care formulations results obtained thermoanalytical techniques indicated compatibility ferulic acid following excipients passion fruit seed oil carbopol ultrez edta crodabase crodamol gtcc dow corning nevertheless analysis also demonstrated possibility interaction ferulic acid following excipients glyceryl stearate rapithix optiphen validate results demonstrated pearson correlation passion fruit seed oil carbopol ultrez edta crodabase crodamol gtcc dow corning glyceryl stearate rapithix incompatibility may compromise ferulic acid properties finally also proved meaningful incompatibility ferulic acid optiphen using pearson correlation thus recommended use optiphen development cosmetic formulations carry ferulic acid
compressive strength thermal conductivity recycled thermal insulation nano concrete different contents recycled aggregates determined comparing micro morphology concluded glazed hollow beads rather air pores reduced strength loss concrete due tight adherence glazed hollow beads cement mortar effective foaming pores strengthen concrete lowering thermal conductivity finally pore fractal dimension established mercury injection test data correlations fractal dimensions various recycled aggregate replacement rates compressive strength thermal conductivity compared discovered macro pore fractal dimensions could used characterize changes concrete strengths average fractal dimension could employed describe variations thermal conductivity concrete
digital signal processing algorithms implemented using fixed point arithmetic due expected area power savings however recent research shows floating point arithmetic used using reduced precision format instead standard ieee floating point format avoid algorithm design implementation difficulties occurs fixed point arithmetic paper simplified single precision floating point arithmetic used perform division square root operations goldschmidt algorithm iterative algorithm speed advantage iterative algorithms fma based goldschmidt algorithm used performing division square root
paper deals evaluation innovative learning materials created within project exemplary developmental projects industry reinforcing practical knowledge future mechanical engineers university west bohemia pilsen uwb faculty mechanical engineering fme department machine design dmd project learning study materials created based themes common technical practice time interesting necessary useful educating students fme entire project divided basic design areas contain one design projects individual design projects worked academics cooperation students also help industry practitioners everything corresponds modern norms standards currently used real industrial companies learning materials created design projects materials implemented teaching several subjects dmd originally intended due extensiveness materials also used teaching departments fme learning materials consist several important parts including dimensional computer aided design cad model calculation drawings technical description etc parts necessary describing structure machine device detail explaining features functions completing project implementing new learning materials teaching necessary evaluate success project impact quality methods teaching questionnaires created given students completion also interested opinions practitioners engineering industry asked employees companies cooperate evaluate study materials using gathered information opinions evaluated quality materials impact teaching mistakes corrected whole project brought successful conclusion
forming limit curves important prediction failure sheet metal forming practical forming operations particularly numerical simulations reliability numerical simulations sheet metal forming processes strongly influenced reliability forming limit curves therefore theoretical aspects experimental determination forming limit curves challenging problems scientific researchers industrial practitioners well various experimental techniques mathematical models used determine forming limit curves spite standardization efforts made recently several institutions world wide still significant differences determining forming limit curves recently new complex measuring system capable automatic determination flcs installed department manufacturing engineering paper first short overview given theoretical background flcs application complex measuring system shown
simulated deep sea environment evolution impedance models water transport behaviours epoxy coating steel surface studied electrochemical impedance spectroscopy eis fitting analysis eis three equivalent electrical circuits eec proposed epoxy coating steel system atm hydrostatic pressure different immersion stages good barrier property coating circuit active corrosion period beginning circuit finally emergency diffusion impedance circuit evolution coating capacitance indicated water transport followed fickian diffusion behaviour initial stage atm hydrostatic pressure atmospheric pressure high pressure accelerated diffusion rates seawater epoxy coatings shortened period water uptake coating reached saturation similar chemical structures epoxy coatings two kinds hydrostatic pressure found fourier transform infrared spectroscopy attenuated total reflection atr measurements high pressure seawater accelerated coating physical failure chemical structures coating change experiment elsevier rights reserved
pairing computer aided design geographical information system data creates opportunity connect architectural design process robust analysis environmental constraints yet geographical information system data may overwhelmingly complex fully used computer aided design without computer assisted methods filtering relevant information article reports implementation integrated environment three dimensional computer aided design environmental impact project focused two way data exchange geographical information system computer aided design building design two different technologies may rely separate representational models combination provide complete view natural built environment challenge integration bridging differences analytical methods database formats approach rooted part constraint based design methods well established computer aided design sketchpad generative components computer aided three dimensional interactive application within computer aided design systems geometrical transformations may intentionally constrained help enforce set design determinants although current implementation modestly relates geometrical constraints use probabilistic risk values central methodology
study tio photoanode modified incorporating zinc nanoparticles improve incident photon conversion efficiency ipce dye sensitized solar cells dsscs effect concentration variation nanoparticles conventional photoanode also studied colloidal suspension method screen printing techniques used fabricate tio nanocomposite photoanode observed ipce tio nanocomposites increased presence maximum efficiency observed tio specimens increased short circuit current jsc open circuit voltage voc compared efficiency reference tio photoanode due surface plasmon quantum capacitance effect elsevier rights reserved
vibration absorbers efficient robust tools reducing vibration noise researchers use various alternative approaches validate methods examples consisting mass spring damper systems focusing minimization vibration amplitudes via passive absorber approach new efficient method calculating optimum parameters absorbers attached uniform beam mode shapes positive integers developed first general case dissipation due damping kinetic potential energy effects external forces analyzed lagrange equation used provide state space representation system state space representation system absorbers mode shapes composed basis state space representation lyapunov function norm transfer function system utilized newly developed optimization package system output minimized optimization algorithm displayed comparison cases without absorber randomly selected absorber parameters conclusion help method calculation optimal absorber parameters one easily design mechanical system according design criteria
objective unusual clinical course background modern antibiotic era streptococcus agalactiae infection endocardium pericardial space rare occurrence however disease spreads lead life threatening illness despite advances diagnostic treatment modalities partly symptoms signs associated pericarditis frequently missing due rarity disease diagnosis often overlooked report extremely rare case purulent pericarditis caused streptococcus agalactiae case report year old diabetic woman presented generalized weakness high grade fever altered mental status signs symptoms suggestive cardiac tamponade presentation computerized tomography scan chest showed small pericardial effusion managed diabetic ketoacidosis sepsis electrocardiogram significant new onset atrial fibrillation clinical status deteriorated rapidly developed acute hypoxic respiratory failure shock bedside echocardiogram showed large pericardial effusion around right ventricle right ventricular diastolic collapse developed cardiac arrest resuscitation bedside pericardiocentesis done drainage serosanguineous fluid however patient could revived subsequently blood cultures grew streptococcus agalactiae day died autopsy found findings infective endocarditis purulent pericarditis conclusions high index clinical suspicion crucial acute pericarditis suspected early diagnosis timely initiation appropriate therapy antibiotics aggressive pericardial drainage prevent fatal outcome
aim review assess effectiveness specific exercise types pulmonary functions aerobic functional capacity patients ankylosing spondylitis systematic search cochrane database systematic review medline ebsco physiotherapy evidence database pedro cinahl ebsco pubmed amed embase ovid conducted january outcome measures spirometric measurements chest expansion minute walk distance mwd pvo bath ankylosing spondylitis functional index basfi bath ankylosing spondylitis disease activity index basdai search strategy applied limitation date language initial electronic search resulted relevant studies duplicates removed titles abstracts articles screened full text articles met initial criteria retrieved review eight studies meeting final inclusion criteria specific conventional exercise groups showed significant improvements basdai basfi scores patients although significant difference two exercise groups pulmonary functions specific exercise groups greater improvements conventional group spirometric measurement chest expansion specific exercises effective adjuvant therapy enhance cardiopulmonary functions patients therefore assumed addition medical treatments specific exercise therapy might reduce cardiopulmonary complications related
paper responds recent calls leadership studies literature anthropologically informed empirical research leadership phenomena non western non anglophone settings authors worked extensively rural development projects laos draw ethnographic observant participation interview data explore leadership construed contested terrain traditional concepts intersect official government international development agencies theoretical discussion linguistic relativity socially constitutive nature language general offered background justification studying language leadership context anthropological distinction etic emic operations also introduced differentiate various interpretative positions taken relation fieldwork data discussed paper study shows difficult native lao speakers find words describe leadership give designations leaders outside officially sanctioned semantic social fields key finding study viewed perspective lao people revolutionary party authority leadership coextensive social fact reflected linguistic restrictions described leadership laos
magnetic properties ferromagnetic cores resistance conductors severely affected high operating temperatures modern electrical machines temperature effects must taken account electrical machine design process optimize performance work proposed simple material model predict change single valued relationship non oriented electrical steel respect temperature temperature dependent power loss curves also measured fitted two term iron loss formula compute magnetic losses temperature dependent magnetic properties relationship power loss formula resistivity values conductors incorporated finite element based computer simulations transformer core induction machine effects temperature different performance parameters magnetic copper losses supply current studied
stacked geotextile structure increased structure protecting beach line structure purpose solving environmental problem well dike three types geotextile tube proposed satisfy desired crest height structure increased stand stability external forces analyzed cross sections stacked geotextile tubes considered external forces wave force tidal force lateral earth pressure reclamation also various field monitoring instrumentations strain gauge earth pressure cell pore pressure measurement inclinometer installed representative geotextile tube section behavior stacked geotextile tube analyzed using field monitoring results tube structure settlement vertical soil pressure bottom tube lateral earth pressure surface strain geotextile tube construction analysis results showed stacked geotextile tube external internal stability seepage analysis showed ground seepage steady monitoring therefore temporary dike structure filling material constructed structural stability considered also height reduction due settlement low pressure filling scouring high velocity tides fine material loss water flow study experimental results behavior stacked geotextile tubes confirmed using numerical method thus analyzing behavior stacked geotextile tubes coastal area numerical method flac improve geotextile tube technology safe construction structures shore
backgroundinadequate nurse staffing reported lead nurses omit required nursing care south korea reduce informal caregiving patient families sitters improve quality nursing care public hospital operated seoul metropolitan government implemented policy increasing nurse staffing patients per registered nurse patients per registered nurse general nursing units since january aimthe study aims compare missed nursing care omission required care high staffing patients per nurse units low staffing patients per nurse units examine effects nurse staffing missed care methodsa nurse survey conducted july targeted staff nurses four high staffing nine low staffing units nurses high staffing units response rate nurses low staffing units response rate participated missed nursing care measured using misscare survey included nursing care elements nurses asked frequently missed element point scale rarely always resultsoverall nurses working high staffing units significantly lower mean score missed care low staffing units seven nursing care elements missed significantly less often high staffing low staffing units turning mouth care bathing skin care patient assessments shift assistance toileting feeding setting meals conclusionthe findings suggest increasing nurse staffing associated decrease missed care less omission required nursing care expected improve nursing surveillance patient outcomes patient falls pressure ulcers pneumonia implications nursing health policyadequate nurse staffing ensured reduce unmet nursing needs improve patient outcomes
introduction occupational stress major factor hindering performance nurses midwives developing physical mental complications given two groups direct contact patients medical staff stress management training effective reduction occupational stress among nurses midwives aim study set compare effect precede proceed based stress management training program occupational stress nurses midwives materials methods quasi experimental study conducted aforementioned nurses midwives data collection instruments included nursing stress scale nss training program held two hour long sessions three months january march results results showed significant increase precede scores groups end program compared baseline significant decrease also observed stress scores groups difference groups regards conclusion precede based stress management training effective reduction occupational stress among nurses midwives
ecopath ecosim ewe widely applied food web model mostly known desktop software microsoft windows platform freely available microsoft net source code ewe however provides range possibilities use model different ways customize extend model execute model different operating systems provide overview ewe source code philosophy technical capabilities targeted model builders advanced users ewe software showcase novel scientific applications ewe model facilitated modular approach system also present three additional versions ewe written different computer languages dedicated purposes lastly provide entry point users obtaining using source code custom purposes elsevier rights reserved
objectives malignant borderline ovarian tumors epithelial origin rarely encountered among prepubertal girls adolescents aim population based study elucidate clinicopathological characteristics prognosis using multi institutional tumor registry study design outcomes national cancer institute surveillance epidemiology end results database accessed cohort females aged years old diagnosed borderline ovarian tumor bot malignant epithelial ovarian carcinoma eoc accessed observed survival assessed using kaplan meier method comparisons made using log rank test results total cases diagnosed bot identified bot serous mucinous histology respectively ten year bot total cases eoc identified median age years common histological subtypes mucinous serous adenocarcinoma stage disease fertility sparing surgery commonly performed five year stage disease compared cases exta ovarian tumor spread conclusions bot eoc exceedingly rare pediatric adolescent population age group eoc consists mostly low grade mucinous serous tumors confined ovary survival stage disease excellent elsevier ireland ltd rights reserved
article presents earsketch learning environment combines computer programming sample based music production create computational remixing environment learning introductory computing concepts earsketch employed formal informal settings yielding significant positive results student content knowledge attitudes toward computing discipline especially ethnic gender populations currently underrepresented computing fields article describes rationale components earsketch evaluation design lessons learned apply future environment design development
method presented modeling tensile behavior multifilament twisted yarns filament assembly model computer aided design computer aided engineering cad cae approach proposed tensile analysis geometry twisted yarn nonlinear filament properties considered finite element method fem large deformation effects applied computation stress extension curves ideal yarn structures five layers different twist angles simulated predict tensile behavior filament layer stress acting filaments yarn extension could directly analyzed fem stress distribution filaments showed highest stress regions located filament center yarn decreased slightly yarn surface stress extensions filaments converted yarn tensile behavior shown terms maximum average stress extension curves results prediction model compared stress strain curves high tenacity rayon yarn energy method maximum stress extension curves showed good agreement experimental results accurate obtained previous methods
predicting grain growth nanocrystalline materials requires modeling approaches incorporate grain boundary thermodynamics kinetics work thermokinetic model chen grain growth applied experimental ray diffraction measurements binary nanocrystalline alloy effort understand influence thermodynamic kinetic material parameters model extend thermokinetic model incorporating temperature dependence model performs well grain boundary saturated case binary nanocrystalline alloy assumed solute segregates grain boundaries thermodynamically kinetically reduces driving force grain growth work sensitivity analysis parameters monte carlo global sensitivity analysis identifies important thermodynamic kinetic parameters correlation one another present model model extended include change independent thermodynamic kinetic parameters function temperature model effect initial grain size distribution research shows thermodynamic kinetic contributions describe grain growth nanocrystalline materials extended model parameterized grain size evolution stabilization temperature nanocrystalline systems published elsevier
letter introduces two new broadband reflective phasers one based shunt stubs one based stepped impedance lines respectively phasers broad bandwidth achieved using electrically short lambda long less therefore non resonant transmission line sections corresponding design procedure presented three numerical two experimental examples subsequently provided validate proposed phasers
network big data important driving force upgrading information technology network data brought great opportunities economic survey openness freedom network also produced possibility private information data destroyed violated security internet becoming important paper author analyzes impact fiscal expenditure new urbanization income gap using data mining technology result shows public expenditure increase lead urbanization rate increase also effect public finance expenditure urbanization certain time lag effect obvious long term time public expenditure help narrow income gap long term public expenditure lag increase lead income gap decrease increasing public expenditure important way promote equalization basic public services urban rural areas
bridges categorised span lengths short span medium span long span super long span also type girder bridges arch bridges cable stayed bridges suspension bridges paper studies long span four types bridges
low temperature electronics operating zero temperatures even lower limit common degrees temperature range essential medical diagnostics space exploration aviation processing storage food mainly scientific research like superconducting materials engineering applications superconducting magnets superconducting energy storage magnetic levitation systems electronic devices demand special approach materials used passive elements sensors main goal work implementation fully transparent flexible cryogenic temperature sensor graphene structures sensing element electrodes made transparent ito indium tin oxide ito ito conductive layers laser ablation finally encapsulated polymer coating helium closed cycle cryostat used measurements electrical properties graphene based temperature sensors cryogenic conditions sensors repeatedly cooled room temperature cryogenic temperature graphene structures characterized using raman spectroscopy observation resistance changes function temperature indicates potential use graphene layers construction temperature sensors temperature characteristics analyzed graphene sensors exhibit clear anomalies strong non linearity entire studied temperature range compared typical carbon sensor
different iron based cathode catalysts studied oxygen reduction reaction orr neutral media applied microbial fuel cells mfc catalysts synthesized using sacrificial support method ssm using eight different organic precursors named niclosamide ricobendazole guanosine succinylsulfathiazole sulfacetamide quinine sulfadiazine pyrazinamide linear sweep voltammetry lsv curves obtained catalysts using saturated potassium phosphate buffer kcl solution rotating ring disk electrode rrde setup order study orr characteristics additionally analyze peroxide yield obtained catalyst helps determine reaction kinetics catalysts mixed activated carbon carbon black ptfe pressed metallic mesh forming pellet like gas diffusion electrode gde results showed ricobendazole niclosamide pyrazinamide highest cathode polarization curves highest power densities output wcm ricobendazole niclosamide pyrazinamide guanosine succinylsulfathiazole sulfacetamide outperformed compared cathode sulfadiazene quinine performed better used control less correlation surface composition performance showed power density achieved directly related total amount nitrogen particularly coordinated metal pyridinic pyrrolic types larger amounts graphitic nitrogen result worse performance authors published elsevier
need simple self assessment tools necessary predict women high risk developing osteoporosis study tools like iof one minute test fracture risk assessment tool frax simple calculated osteoporosis risk estimation score found valid palestinian women threshold predicting women risk tool estimated purpose purpose study evaluate validity updated iof international osteoporosis foundation one minute osteoporosis risk assessment test frax score well age alone detect risk developing osteoporosis postmenopausal palestinian women methods three hundred eighty two women years older recruited including women osteoporosis controls following bone mineral density bmd measurement completed questionnaires different risk assessment tools receiver operating characteristic roc curves evaluated tool using bone bmd gold standard osteoporosis results area roc curve auc highest frax calculated bmd predicting hip fractures followed frax major fractures cut values respectively iof one minute test auc lowest compared tested tools sufficient accuracy predicting risk developing osteoporosis cut value total yes questions score test age alone also good predictors risk developing osteoporosis according roc curve age women years higher risk developing osteoporosis higher percentage women low bmd score osteoporosis tscore found among women exposed sun menopause age years lower body mass index bmi compared controls women often fall lower bmi approximately recruited postmenopausal palestinian women accidents caused fractures conclusions simple self assessment tools like frax without bmd score iof one minute tests valid predicting palestinian postmenopausal women high risk developing osteoporosis
explosion character animation across contemporary screen media people disciplines technologies engaging production explicit representations computer animation processes help facilitate engagement high level however fail convey depth specialised creative techniques technical processes discipline language prevalent act animating paper introduces production model conceptual process novel use software engineering methodology agent oriented modelling conveys specialised attributes within explicit process producing character animation gather insights model used perceived animators within production environment entrenched within large undergraduate student animation project named gunter fables positioned principal device inform animators production process expected activity project management team also used model weekly peer review sessions basis evaluate animation convey progress achievement colour rating scale upon completion production phase project student animators successfully delivered short second character animation scenarios deemed consistent fit purpose quality findings regular sweatbox review sessions questionnaires suggest investigation iterative development model may improve user engagement process however model demonstrated ability inform depth production process supports notion novel production concept presents way forward communication production character animation allied animation activities
study analysis variance anova cluster analysis principal component analysis pca employed order evaluate concentration profile organic contaminants found three main river central transylvania romania samples collected nine sampling stations two different sampling campaigns wet season dry season water samples extracted using solid phase extraction analyzed using gas chromatography coupled mass spectrometry twelve organic pollutants belonging different classes used interpretations anova highlighted compounds distinguished olt river mures river compounds influenced increased river flow wet season applied group sampling stations three clusters obtained according organic load pca extracted five principal components explaining data set variability based results future monitoring study may optimized reducing sampling points compounds representative river thereby reducing costs without information loss
study design analysis combined prospective dataset objective compare clinical outcomes patients without preexisting depression bipolar disorder undergoing surgery degenerative cervical myelopathy dcm summary background data psychiatric comorbidities including depression associated worse clinical outcomes lumbar spine surgery however unclear whether psychiatric disorders also predictive outcomes patients undergoing surgery treatment dcm methods four hundred one patients symptomatic dcm enrolled prospective aospine international north america study twelve north american sites patients evaluated preoperatively months using modified japanese orthopedic association scale mjoa nurick score neck disability index ndi short form health survey mixed model analytic approach used evaluate differences outcomes months among patients without psychiatric disorders controlling relevant baseline characteristics surgical factors results ninety seven patients diagnosed preexisting depression bipolar disorder females psychiatric disorders males patients psychiatric comorbidities likely cardiovascular respiratory gastrointestinal rheumatologic neurologic disorders months surgery patients groups demonstrated significant improvements mjoa nurick ndi physical component score pcs patients depression bipolar disorder however exhibit significant clinically important change mental component score mcs differences mjoa nurick scores months among patients group improvement ndi pcs mcs however smaller patients depression bipolar disorder without conclusion patients depression bipolar disorder smaller functional quality life improvements surgery compared patients without psychiatric comorbidities
first goal study investigate whether levels overparenting behavior anticipatory problem solving advice affect management tangible assistance low levels child self direction differ depending context arab israeli jewish israeli mothers fathers second considered whether association overparenting young adults interpersonal sensitivity depends contexts questionnaires collected triads mothers fathers young adults jewish israeli arab israeli parents reported overparenting behaviors young adults reported interpersonal sensitivity results indicated four dimensions overparenting behaviors prominent arab israeli culture jewish israeli culture advice affect management lower mothers fathers fathers provided child self direction mothers addition higher levels anticipatory problem solving significantly associated higher levels young adult interpersonal sensitivity independent parental gender cultural background supporting general negative association anticipatory problem solving interpersonal sensitivity
background magnetic resonance imaging mri sensitive technique evaluating healing process performed patients return exercise routines aim research diagnose chronic lumbago associated lumbar muscle strain monitor healing process mri methods sixty five symptomatic cases chronic lumbago caused lumbar muscle strain collected march october mri used examine diagnose monitor healing process control group included random cases asymptomatic volunteers mri methods included routine sequences gre twi tse twi special sequences stir combined dwi compared mri characteristics symptomatic cases healing asymptomatic controls results important mri characteristics chronic lumbago lumbar muscle strain included low back muscle showed edema low back intermuscular spaces showed edema fluid low back spaces beside spinous process showed edema fluid low back vertebral articular process fossae transverse process fossae showed fluid image characteristics intermuscular space edema provided best diagnostic sensitivity low back muscle edema provided best diagnostic specificity spaces edema beside spinous process provided best diangnostic accuracy diagnosis accurate could improved combining multiple mri characteristics diagnostic accuracy could achieve two characteristics combined rehabilitation care edema disappeared repeated mri conclusions mri may well useful diagnostic method lumbago lumbar muscle strain combining routine sequences stir dwi sequences could demonstrate pathological changes lumbar muscle strain monitor healing
aim aim research evaluate leaf removal red geotextile reflective mulch vitexsol could affect phenolic composition wines three white cultivars riesling italico traminer manzoni bianco methods results two year study conducted evaluate effects leaf removal reflective mulch phenolic composition white wines zagreb vineyards northwestern croatia leaf removal reflective mulch vitexsol made weave aluminum platelets protected transparent film sewn together red polypropylene threads tested separately combined vines traminer riesling italico manzoni bianco consistent effect must sugar content titratable acidity treatments resulted higher total phenol flavan content wines cultivars different years generally resulted highest phenolic acid individual flavan content wines except traminer treatment least effect phenolic composition wines conclusion generally resulted highest content phenolic compounds especially compared control wines significance impact study work provides useful informations adjusting vineyard practices thus optimizing phenolic quality white wines
background evidence informed policymaking likely organisations cultures promote research use invest resources facilitate staff engagement research measures organisations research use culture capacity needed assess current capacity identify opportunities improvement examine impact capacity building interventions aim current study develop comprehensive system measure score organisations capacity engage use research policymaking entitled oracle organisational research access culture leadership method used multifaceted approach develop oracle firstly reviewed available literature identify key domains organisational tools systems may facilitate research use staff interviewed senior health policymakers verify relevance applicability domains information used generate interview schedule focused seven key domains organisational capacity interview pilot tested within four australian policy agencies discrete choice experiment dce undertaken using expert sample establish relative importance domains data used produce scoring system oracle results oracle interview developed comprised questions addressing seven domains organisational capacity tools support research use including documented processes policymaking leadership training staff training research resources database access systems generate new research undertake evaluations strengthen relationships researchers dce data conditional logit model estimated calculate total scores took account relative importance seven domains model indicated expert sample placed greatest importance domains conclusion utilised qualitative quantitative methods develop system assess score organisations capacity engage apply research policy measure assesses broad range capacity domains identifies relative importance capacities oracle data used organisations keen increase use evidence identify areas development
present hand held optical biosensing system utilizing smartphone embedded illumination sensor integrated immunoblotting assay method smartphone embedded illumination sensor regarded alternative optical receiver replaces conventional optical analysis apparatus illumination sensor respond ambient light wide range wavelengths including visible infrared demonstrate biosensing applicability system employing enzyme mediated immunoblotting accompanying light interference various types ambient light conditions including outdoor sunlight indoor fluorescent tested immunoblotting assay biosensing channel generating insoluble precipitates end product enzymatic reaction fabricated mounted illumination sensor smartphone intensity penetrating light arrives illumination sensor inversely proportional amount precipitates produced channel changes immediately analyzed quantified via smartphone software study urinary terminal telopeptide fragment type collagen uctx biomarker osteoarthritis diagnosis tested model analyte developed smartphone based sensing system efficiently measured uctx concentration range high sensitivity accuracy various light conditions assay results show illumination sensor based optical biosensor suitable point care testing poct elsevier rights reserved
psoriasis among common dermatological diseases worldwide significance emphasized adverse effects quality life caused chronic pain physical psychical disability due psoriatic plaques besides development psoriatic arthritis often causes permanent joint damage former studies revealed increased risk inflammatory bowel disease cardiovascular disease certain types cancer genetic predisposition oxidative stress caused exogenous endogenous factors contribute abnormal differentiation hyper proliferation keratinocytes accordingly development maintenance psoriasis moreover excessive oxidative stress responsible onset psoriasis complications brief pathophysiological summary authors discuss role oxidative stress development psoriasis complications several well studied biomarkers asymmetric dimethylarginine malondialdehyde superoxide dismutase catalase
communicate face face subconsciously engage whole body convey message telecommunication phone calls powerful information channel used capturing nonverbal information body motion transmitting receiver parallel speech would make conversations feel much natural requires sensing device capable capturing different types movements flexion extension joints rotation limbs first embodiment developed sensing glove used control computer game capacitive dielectric elastomer sensors measure finger positions inertial measurement unit imu detects hand roll two sensor technologies complement imu allowing player move avatar three dimensional maze sensors detecting finger flexion fire weapons open doors demonstrating potential sensor fusion human computer interaction take concept next level apply nonverbal communication humans current fingerspelling glove prototype uses capacitive sensors detect finger gestures performed sending person gestures mapped corresponding messages transmitted wirelessly another person concept integrating imu system presented fusion sensor imu combines strengths sensor types therefore enables comprehensive body motion sensing makes large repertoire gestures available nonverbal communication distances
paper presents experimental study system interesting crossover standard benchmark control problem smart material study represents effect stress strain temperature bandwidth antagonistic shape memory alloy sma relative performance influencing stability system experiment implicated underactuated open loop unstable ball beam system designed developed driven sma proportional derivative controller cascaded sliding mode controller smc based simplified fuzzy adaptive sliding surface considered study dynamics system designed simplified fuzzy based sliding surface controller able balance ball beam system around equilibrium state control perspective shows performance controller better conventional smc furthermore smart material perspective decisive results arrived handle issues like stability speed operation performance antagonistic sma elsevier rights reserved
self supported single poles widely used transmission electricity rural areas india recently unnao district uttar pradesh india large number self supported poles found suffer extensive tilting wind storms incident raised safety concerns government well company charge construction installation poles prestressed concrete poles height embedded ground per standard practice visual inspection failure sites detailed geotechnical investigation soil nearby boreholes seemed failures caused primarily due inadequate resistance soft soil indo gangetic plain resulting bearing overturning failures order understand test setup created institute technology kanpur full scale poles brought unnao erected specifically prepared soil pit match situ soil condition unnao case study sites poles erected compacted silty clay soil deposit adopting standard procedure back filling used site poles subjected lateral loading unloading specially designed frame load capacities poles found range times design wind load chosen sites noted increasing footing dimension capacity pole improved also found replacing concrete footing compacted brick stone aggregate grouted footing common practice rural india significant alteration load capacity force deformation behavior observed numerical study also conducted understand experimentally observed behavior found study analytical model considering nonlinear soil pole interaction case showed better prediction experimental behavior fixed base model case finally sensitivity analysis using first order second moment fosm method indicated cohesion influences load capacity poles significantly compared soil parameters friction angle unit weight shear modulus chosen soil type available soil exploration data elsevier ltd rights reserved
background examine whether stress management mediates relationship purpose life self rated health status srh methods cross sectional survey conducted among teachers guangzhou china purpose life assessed purpose life subscale psychological well scale stress management assessed using eight item questionnaire adapted health promoting lifestyle profile srh assessed suboptimal health measurement scale version mediation hypothesis tested structural equation model path analysis results found purpose life direct indirect effects srh path analysis showed total effect beta purpose life srh comprised direct effect beta indirect effect beta mediated stress management conclusions supporting mediation hypothesis results indicate stress management mediated effect purpose life srh enhancement teachers purpose life improvement training skills stress management incorporated strategy improving teachers health
energy storage resources esrs inherent building structures viable attractive option improve power system operation providing demand side flexibility paper proposes two stage optimisation framework price based demand response commercial buildings include variable speed heat pumps vshps proposed framework aims assisting commercial building aggregators devise beneficial strategy exploiting thermal esrs response electricity prices specifically paper thermal dynamics vshps modelled detail using set piecewise linear equations two different methods room temperature control energy consumption reserve provision vshps well plug electric vehicles optimised considering operating conditions distribution networks dns pre post contingency states wind power generation simulation case studies performed estimate effects building esrs optimal operation power systems commercial buildings various conditions characterised temperature control methods esr penetration levels operational constraints elsevier ltd rights reserved
aggressive behaviour among school children raised cause concern malaysia development aggressive behaviour places children serious risk future mal adaptation form continued aggression conduct problems overall difficulties domain social relationships therefore need study origins development aggressive behaviour paper focuses nature aggressive behaviour among school children theories underlying aggressive behaviour impact media violence development aggressive behaviour school children published elsevier ltd
present pipeline algorithms decomposes given polygon model parts part printed high outer surface quality exploit fact printing technologies anisotropic resolution hence surface smoothness varies significantly orientation surface pipeline starts segmenting input surface patches normals aligned perpendicularly printing direction voronoi diagram computed intersections voronoi cells surface approximate surface patches intersections voronoi cells input model volume provide initial decomposition present algorithm compute assembly order parts generate connectors post processing step optimizes seams segments improve visual quality run pipeline wide range models experimentally evaluate obtained improvements terms numerical visual haptic quality
introduction telehealth widely promoted technology make healthcare effective affordable however current telehealth systems suffer vendor lock high cost designed managing chronic diseases rather preventing methods address shortcomings existing consumer level health informatics applications supporting senior health consumers provide designers systems design framework assess feasibility patient centred health management systems hmss designed based proposed framework contrast traditional telehealth hmss patient centred aim enabling health consumers take control health providing functionality health self management quantitative qualitative methods adopted evaluating prototype hms results senior healthcare consumers viewed hms prototype positively experienced positive change attitude towards health identified requirements challenges hmss particular participants indicated social networking features must clear purpose beyond simple broadcasting emotions opinions discussion study indicates seniors able motivated leverage web based patient centred hms provided suitable health support applications tailored needs could achieved making attractive third party application developers contribute hms content
order reveal hyperplasticity mechanism electromagnetic forming emf plastic instability mechanisms formation behaviors aluminum alloy sheets pulsed magnetic tension process investigated theoretical analysis microanalysis results show inertia force plays important role dynamic forming suppression effect structural instability thus improves formability sheet spreads instability nature dynamic formation much similar quasi static formation special formation structures arise dynamic process aluminum alloy sheets formation mechanism processes dislocation slip mechanism quasi static formation dislocations show uniform single slip pattern fracture combined dislocation tangling climbing dynamic formation dislocation system tends slips large areas showing clear cross slip structures dislocation bands narrower much denser shown quasi static process much uniform dislocation configuration also exhibited pulsed magnetic loadings characteristics multi slips uniform effect dislocations pulsed magnetic loading conditions result much higher plasticity strength materials
present review work devoted potentiometric sensors based high temperature proton conducting ceramic materials technology developments possible application sensors determination concentration hydrogen containing components gases solids melts described thoroughly discussed special attention devoted analysis experimental data already appeared international literature adequacy basic operation principles base analysis existing problems future trends revealed discussed elsevier rights reserved
study aimed describe rates antipsychotic medication use association use demographics clinical variables use behavioral education services among children asd children asd ages prescribed least one atypical antipsychotic medication respectively multivariable model young children older age use multiple psychotropic medications prior asd diagnosis non white hispanic race ethnicity oppositional defiant problems associated antipsychotic use among older children older age associated antipsychotic use least one age group antipsychotic medication use also related behaviour family occupational therapy public insurance site region externalizing problems body mass index sleep gastrointestinal problems
propose pair techniques lower energy consumed driving pixel liquid crystal displays lcds first one employs multiple capacitors divides lcd two lower drive voltage simulations show large capacitance values many capacitors reduce energy consumed stacking two thin low voltage lcds maximizes effect decreasing overhead consumed microcontroller actual polymer dispersed lcds pdlcds tested confirm techniques work effectively simulations imply results show overall energy consumption large pdlcds reduced using multiple capacitors combination two techniques successfully reduces driving energy even small lcds polarity reversal proposed technique incur delay confirmed flicker test technique degrade image quality
software defined network structure network fundamental changes network equipment achieve hardware software isolation virtualization technology underlying hardware development network provides platform due hardware software isolation making network vulnerable attack thus changing topology business information solve problem paper depending traffic data corresponding topology method gives security software defined network combined business process model cloud computing network security algorithm optimization simulation results show proposed method robust variety business effectively prevent network attacks
downy mildew pathogens affect several economically important crops worldwide due obligate nature genetic resources available genomic population analyses draft genomes emergent downy mildew pathogens oomycete pseudoperonospora cubensis causal agent cucurbit downy mildew published used perform comparative genomic analysis develop tools microsatellites characterize pathogen population structure used bioinformatics identify microsatellites cubensis predicted transcriptome evaluate transferability hop downy mildew pathogen pseudoperonospora humuli since draft genome available species also compared microsatellite repertoire cubensis model organism hyaloperonospora arabidopsidis causes downy mildew arabidopsis although trends frequency motif type similar percentage ssrs identified cubensis transcripts differed significantly arabidopsidis majority subset microsatellites selected laboratory validation produced product cubensis isolates microsatellites demonstrated transferability humuli eleven microsatellites found polymorphic consistently amplified cubensis isolates analysis pseudoperonospora isolates diverse hosts locations revealed higher diversity cubensis compared humuli isolates microsatellites useful efforts better understand relationships within pseudoperonospora species cubensis population level
application conditional free shipping policy becoming extensive research theories confirm free shipping conditions shipping cost becoming important problem faced commerce enterprises make example analysis series solutions generated based algorithm design program design solving model attain conclusions product price within psychological expectation range consumers product free shipping threshold set boundary product price portfolios situation retailer profit jump happen addition optimal free shipping threshold set around mean value consumer expectation distributes course pricing strategy optimal delivery service enterprise also affected various factors forms complicated depend specific value parameters
study robust sliding mode learning control scheme proposed address congestion control problem differentiated services diffserv networks validated non linear network model based fluid flow theory corresponding two important services namely premium traffic ordinary traffic proposed congestion controller able efficiently cope physical network resource constraints unknown time delays associated networking systems numerical results presented illustrate effectiveness proposed control scheme
study aimed study whether cancer cells possess distinguishing metabolic features compared surrounding normal cells increased glutamine uptake given quantitative measures glutamine uptake may reflect critical processes oncology approximately patients colorectal cancer crc express braf may actionable selective braf inhibitors combination inhibitors complementary signaling axes non invasive quantitative predictive measures response targeted therapies remain poorly developed setting primary objective study explore fluoroglutamine gln positron emission tomography pet predict response braf targeted therapy preclinical models colon cancer tumor microarrays patients primary human colon cancers crc liver metastases used evaluate prevalence asct primary glutamine transporter oncology immunohistochemistry subsequently gln pet evaluated mouse models human braf expressing braf wild type crc approximately primary colon cancers metastases exhibited positive asct immunoreactivity suggesting gln pet could applicable majority patients colon cancer asct expression associated selectively expression mutant braf decreased gln predicted pharmacological response single agent braf combination braf pik mtor inhibition braf mutant colo tumors contrast similar decrease observed braf wild type hct tumors setting braf targeted therapies ineffective gln pet selectively reflected pharmacodynamic response braf inhibition compared deoxy fluoro glucose pet decreased non specifically treated cohorts regardless downstream pathway inhibition findings illustrate utility non invasive pet imaging measures glutamine uptake selectively predict response braf targeted therapy colon cancer may suggest opportunities inform colon cancer clinical trials using targeted therapies mapk activation
future energy infrastructure considerable potential biogas particular biomethane natural gas substitute among alternatives upgrading biogas biomethane work focuses membrane permeation taking cellulose acetate membrane material spiral wound membrane configuration five layouts assessed layouts biogas plant rated stp yet may adopt one two stage permeation permeate residue recycle iii water heater prime mover internal combustion engine micro gas turbine exploit residues fuel gas since residues consumed layouts zero emission methane atmosphere membrane material modeled considering phenomenon plasticization membrane modules described crossflow permeation patterns without pressure drops results indicates specific membrane areas range stp specific energy kwh stp exergy efficiencies splitting permeation two stages adoption water heater instead prime movers convenient option preferred layout employs single compressor two stage membrane permeation bar water heater fueled first stage permeate second stage permeate recycle assuming biomethane incentive sic mwh lhv project life years total investment plant sic payback time years net present value sic elsevier ltd rights reserved
objectiveto predict changes wage growth health care workers based projections insurance enrollment affordable care act aca data sourcesenrollment data came three large employers sampling premiums ehealthinsurance com information state medicaid eligibility rules costs kaiser family foundation national predictions based meps medicare current beneficiary surveys bureau labor statistics data used estimate employment study designwe projected health insurance enrollment plan type using health plan choice model using claims data measured services demanded plan choice year projections labor demand based current output input ratios changes wages resulting changes labor demand based labor supply demand elasticities principal findingsexpenditures required retain grow health care workforce increase substantially wages increase professions greatest training requirements physicians registered nurses largest impact felt conclusionsprojected wage increases health care workers may drive substantial growth insurance premiums reduce affordability health insurance
linear circuits systems generally described traditional differential equations integer order transfer functions based assumption dynamics lumped time invariant however compared conventional integer order calculus many dynamical systems better represented fractional calculus interaction among variables modelled fractional integration fractional differentiation present work proposes generalized approach identification fractional order systems frequency domain using experimental data achieve system identification task framed optimization problem solved using seeker optimization algorithm algorithm seeks attain set system parameters deviation simulated response identified system experimental data minimized proposed approach validated set electrical circuits varying configuration simulation experimental results reveals test circuits better represented fractional order model wide range frequency
although anti retroviral treatments significantly reduced incidence mother child transmission hiv aids remains foreseeable future group adolescents perinatally infected noting paucity information regarding impact paediatric aids intersection residential care paper investigates lived realities south african adolescents vertically infected hiv aids abandoned raised residential care exploratory study highlights youth dimensions adolescence hiv positive status associated abandonment well life residential care mutually reinforcing interconnected issues race class also interact social dimensions ultimately dimensions intersect create particular form social exclusion intentional critical intervention required micro level support teens develop coherent identity meso level residential facility actively facilitate community integration particularly adolescents communities possible families origin governments need strengthen intersectoral rights based responses particular address consequences cognitive impairment associated perinatal transmission
disruptive behavior disorders dbd among commonly diagnosed mental disorders children adolescents important characteristics dbd vary based presence absence comorbid attention deficit hyperactivity disorder adhd may affect understanding treatment decision making related disorders thus identifying neurobiological characteristics dbd comorbid adhd dbd adhd provide basis establish better understanding condition study aimed assess abnormal white matter microstructural alterations dbd adhd compared dbd alone healthy controls using diffusion tensor imaging dti thirty three dbd comorbid adhd age matched healthy adolescents studied using dti fractional anisotropy mean diffusivity radial diffusivity axial diffusivity analyzed using tract based spatial statistics tbss significantly lower higher many white matter fibers found adolescents dbd adhd compared controls moreover lower higher also found dbd adhd versus dbd alone group alterations white matter integrity found dbd patients primarily associated adhd suggesting adhd comorbidity dbd reflected greater abnormality microstructural connections elsevier ireland ltd rights reserved
tested prognostic impact marker arterial stiffness pulse pressure stroke volume index svi patients hypertension left ventricular hypertrophy used data patients randomized losartan atenolol based antihypertensive treatment median years losartan intervention endpoint reduction hypertension life study association svi outcomes tested cox regression analyses reported hazard ratio confidence intervals multivariate regression reduction svi independently associated male gender reduction systolic blood pressure relative wall thickness increase left ventricular ejection fraction adjusting confounders higher baseline svi predicted higher hazard combined major fatal non fatal cardiovascular events higher hazard cardiovascular mortality stroke higher svi also predicts higher rate hospitalization higher hazard cause mortality hypertensive patients electrocardiographic hypertrophy higher svi associated increased cardiovascular morbidity mortality
systems chip among best performing complete solutions complex electronic systems also true field network security application requiring high performance low resource usage work presents advanced encryption standard implementation systems chip using reference cipher block chaining mode particular flexible interface based advanced peripheral bus integrate encryption algorithm kind processor presented hardware software approach architecture also analyzed described final system integrated xilinx zynq prototype evaluate idea results show solution demonstrates good performance flexibility low resource usage occupying less zynq throughput mbps architecture suitable implementations symmetric encryption algorithms modern systems chip required
purpose review review shows less constant rate tip base vessel widening across species together assumption wider vessels vulnerable embolism suggests climate limit maximum vegetation height together two factors predict maximum mean vessel diameter permitted temperature water availability site thus maximum plant height recent findings empirical work makes increasingly clear main driver variation mean vessel diameter plant size specifically length conductive stream anatomical evidence together hydraulic optimality models suggests vessel diameter stem length relationship result natural selection favoring maintenance constant hydraulic resistance size increases narrow termini vessels widen predictably stem tip base following approximately power law rapid widening toward tips nearly constant diameter toward base size dependence must taken account studying hydraulics climate relationship summary review discusses outstanding predictions require testing including following variation vessel diameter stem length relationship involve factors vessel length distributions pit characteristics leaf area wood density leaves higher trees higher terminal leaf vein petiole base vessel widening rates species without disposable units columnar cacti might different widening rates within plant widening rate vary plants approach height limits finally emphasize need standardize size making comparisons vessel diameter variation
functional dyspepsia common disorder east southeast asia subjects experience post prandial fullness bloating early satiety belching epigastric pain burning subset patients experience triggers exclusively related meals defined post prandial distress syndrome rome guidelines significant overlap symptoms implicated pathogenic factors another common functional gastrointestinal disorder irritable bowel syndrome ibs fact significant proportion subjects ibs overlap introduction low fodmap diet changed paradigm treatment ibs like ibs dietary management appears important patients clinicians treating condition review aims examine current role diet management east southeast asia exploration likely efficacy mechanisms action low fodmap diet region
objectiveusing surface based morphometry aimed provide detailed examination cortical alterations medication overuse headache moh disentangling altered cortical thickness gyrification folding backgroundin moh pain modulation probably dysfunctional cortical subcortical level resulting disequilibrium pain inhibition facilitation increased decreased cortical volumes reported individuals moh however detailed examination date distinguishes altered cortical thickness gyrification distinction would help identify nature timing neurodevelopmental mechanisms play affected individuals methodswe investigated cortical thickness gyrification patients moh according international headache society criteria age gender matched controls using high resolution structural mris brain analyzed freesurfer secondary analysis data previously published voxel based morphometry study resultsin patients moh compared controls reduced cortical thickness observed left prefrontal cortex also observed higher local gyrification one cluster extending fusiform cortex adjacent medial temporal regions another cluster right occipital pole higher gyrification right occipital pole predicted poor response detoxification conclusionscorroborating previous volumetric results study adds information putative neurobiological mechanisms involved moh suggesting neurodevelopmental changes moh
background month open label extension study assessed long term safety tolerability lisdexamfetamine dimesylate ldx adults binge eating disorder bed methods adults aged bed completed antecedent studies enrolled week open label extension study dose optimization weeks initial titration dose ldx target doses ldx dose maintenance weeks safety evaluations included occurrence treatment emergent adverse events teaes vital sign weight assessments columbia suicide severity rating scale responses results enrolled participants women men comprised safety analysis set completed study mean ldx exposure days cumulative ldx exposure duration months longer participants total participants reported teaes teaes leading treatment discontinuation severe teaes serious teaes treatment emergent adverse events reported greater equal participants dry mouth headache insomnia upper respiratory tract infection mean changes antecedent study baseline systolic diastolic blood pressure pulse weight week early termination beats per minute respectively columbia suicide severity rating scale positive responses active suicidal ideations positive responses suicidal behavior completed suicides conclusions month open label extension study long term safety tolerability ldx adults bed generally consistent established profile attention deficit hyperactivity disorder
virtually cells organism secrete extracellular vesicles evs heterogeneous population lipid bilayer membrane enclosed vesicles transport deliver payloads proteins nucleic acids recipient cells thus playing central roles cell cell communications exosomes nanosized evs endosomal origin regulate many pathophysiological processes including immune responses inflammation tumour growth infection healthy subjects patients different diseases release exosomes different rna protein contents circulation measured biomarkers discovery exosomes natural carriers functional small rna proteins raised great interest drug delivery field may possible harness vesicles therapeutic delivery mirna sirna mrna lncrna peptides synthetic drugs however systemically delivered exosomes accumulate liver kidney spleen targeted exosomes obtained displaying targeting molecules peptides antibody fragments recognizing target antigens outer surface exosomes display glycosylphosphatidylinositol gpi anchored nanobodies evs novel technique enables display variety proteins including antibodies reporter proteins signaling molecules however naturally secreted exosomes show limited pharmaceutical acceptability engineered exosomemimetics incorporate desirable components natural exosomes synthetic liposomes nanoparticles assembled using controllable procedures may acceptable pharmaceutically communication review current understanding physiological pathophysiological roles exosomes potential applications diagnostic markers current efforts develop improved exosome based drug delivery systems elsevier inc rights reserved
background hereditary angioedema hae rare genetic disorder characterised episodes swelling without urticaria berinert csl behring plasma derived human inhibitor inh concentrate approved treatment hae inh deficiency inh hae however often used label europe treat hae normal inh objectives report clinical characteristics patients hae normal inh gene mutation fxii hae unknown origin hae response berinert materials methods data obtained retrospectively french cohort berinert angiaedeme cobra registry hae patients everyday use berinert analysed control group included diagnostic criteria fxii hae hae included normal inh antigenic level function refractoriness high dose antihistamines fxii hae diagnosis also included gene mutation hae positive family history disease results date patients fxii hae hae identified mean age years first angioedema attack years female documented berinert treated attacks majority occurring laryngeal abdominal regions efficacy assessment berinert available documented berinert treated attacks improved within minutes treatment initiation nine within minutes four minutes three showed improvement severe serious adverse effects reported conclusion data date suggest berinert may safe efficacious treatment option majority hae patients
background functional brain imaging research already demonstrated patients schizophrenia difficulties emotion processing namely facial emotion perception emotional prosody however moderating effect social context boundary perceptual categories emotion attribution remain unclear study investigated neural bases emotional sentence attribution schizophrenia methods twenty one schizophrenia patients healthy subjects underwent event related functional magnetic resonance imaging paradigm including two tasks one classify sentences according emotional content classify neutral sentences according grammatical person results first patients showed longer response times compared controls emotion attribution task second patients schizophrenia showed reduction activation bilateral auditory areas irrespective presence emotions lastly emotional sentences attribution patients displayed less activation controls medial prefrontal cortex mpfc conclusions suggest functional abnormality observed mpfc emotion attribution task could provide biological basis social cognition deficits patients schizophrenia elsevier rights reserved
communication act information transfer sender receiver rats vocal communication studied ultrasonic vocalizations usv khz usv occur appetitive situations notably juvenile play likely expressing sender positive affective state appetitive khz usv serve important pro social communicative functions elicit social exploratory approach behavior receiver emission khz usv induced pharmacologically administration psychostimulant drugs amphetamine however unknown whether amphetamine affects pro social communicative function khz usv receiver therefore assessed dose response effects amphetamine pro social ultrasonic communication sender receiver juvenile rats found inverted shaped effect amphetamine khz usv emission khz usv levels strongly enhanced moderate doses yet less prominent effects seen following highest dose likewise amphetamine exerted inverted shaped effects social exploratory approach behavior induced playback appetitive khz usv social approach enhanced moderate amphetamine doses completely abolished following highest dose amphetamine dose dependently promoted emission khz usv following playback appetitive khz usv indicating vigorous attempts establish social proximity results support important role dopamine closing perception action loop linking mechanisms relevant detection production social vocalizations moreover approach possibly provides new means study mania like aberrant social interaction communication animal models bipolar disorder elsevier ecnp rights reserved
drawing together social psychologists concerns equality cognitive psychologists concerns scientific inference studies showed implicit category norms make generation test hypothesis race highly asymmetric shown whiteness default race celebrity actors study study used variant wason rule discovery task demonstrate greater difficulty discovering rules require specifying race shared white celebrity actors black celebrity actors clues whiteness white actors analogous problems little effect hypothesis formation rule discovery studies rather across studies feedback negative cases non white celebrities facilitated discovery white actors shared race whether participants experimenters generated negative cases category norms little affected making white actors whiteness informative study although participants understood discovering white actors white would harder discovering black actors black showed limited insight information contained negative cases study category norms render identities implicit defaults making hypothesis formation generalization real social groups asymmetric ways implications scientific reasoning social equality
idiopathic pulmonary fibrosis ipf chronic progressive interstitial lung disorder showcasing interaction genetic predisposition environmental risks usually involves coaction mixture cell types associated abnormal wound healing leading structural distortion loss gas exchange function ipf bears fatal prognosis due respiratory failure revealing median survival approximately years review showcases ongoing progress understanding complex pathophysiology ipf highlights latest potential clinical treatments ipf various components immune system particularly clotting cascade shortened telomeres highly involved disease pathobiology progression review also illustrates two food drug administration fda approved drugs nintedanib ofev boehringer ingelheim ingelheim rhein germany pirfenidone esbriet roche basel switzerland slow ipf progression unfortunately neither drug reverse course disease although mechanisms underlying ipf remain poorly understood review unveils past current advances encourage detection new ipf pathogenic pathways development effective treatment methods near future
years number high quality studies established effectiveness external measures tape brace neuromuscular training prevention ankle sprains general conclusion derived studies recurrent ankle sprains effectively prevented using measures measures cost beneficial nevertheless despite commonness type injury availability effective measures implementation prevention clinical practice lagging behind addition although proven effective link biomechanical neurophysiological adaptations function preventive measures leading clinical functional improvements ultimately ankle sprain recurrence prevention never fully made current evidence ankle sprains prevention provides ample opportunities pursue translational approach fundamental knowledge provide guidance specify effective preventive program bare essentials decrease user burden retaining full effectiveness
japan leading global trend decreasing birth rates graying society study examine women changing gender intergenerational relationships affect concerns hopes futures many midlife women aged interviewed viewed sandwiched mothers law actual potential daughters law nadir intergenerational status within families large part due changing social patterns marriage birth rates doubts marriageability sons arising role expectations brides care parents law cause concern many highlight gendered intergenerational nature aging concerns yet midlife century changing gender intergenerational roles appears create opportunities many japanese women reflect meaning next stage lives changing gender intergenerational relationships may contribute hopes live life self actualization true one self jibun rashiku ikiru
conceptualizing technological innovation capabilities cloud platform implementation construction management context still rudimentary primary objective study validate model assessing relationships among information platform usage technological innovation capabilities capital facility project performance study also evaluated moderating role type platform relationships study empirically investigated sample projects taiwanese construction industry structural equation modeling sem approach used validate research model testing moderation effect two way analysis variance anova used findings indicate implementation information platform contrubutes significantly technological innovation capabilities addition analyses suggest technological innovation capabilities positive effect project performance results also show relationship information platform usage technological innovation capabilities depends type platform traditional cloud based information management platform indicates association technological innovation capabilities project performance strongly evident projects use cloud platform
background levodopa carbidopa intestinal gel therapy lcig efficiently improve several motor non motor symptoms advanced parkinson disease recently developed movement disorder society sponsored unified parkinson disease rating scale mds updrs improved original updrs making robust tool evaluate therapeutic changes however previous studies used mds updrs unified dyskinesia rating scale udysrs assess efficacy lcig objectives aim determine mds updrs udysrs could detect improvement experiences daily living following year lcig treatment methods prospective multicenter open label study consecutive patients undergoing lcig treatment enrolled patients examined twice prior lcig initiation months later impact related symptoms dyskinesia assessed mds updrs udysrs results non motor experiences daily living part mds updrs improved median interquartile range iqr points median iqr motor experiences daily living ameliorated median iqr points median iqr health related quality life measured pdq also improved median iqr median iqr points total score udysrs decreased median iqr median iqr points conclusions far authors aware paper first evaluate impact lcig dyskinesia means udysrs changes mds updrs udysrs confirm lcig treatment efficiently improve experiences daily living advanced elsevier ltd rights reserved
backgroundthe incidence degenerative aortic valve diseases increased along life expectancy population although conventional aortic valve replacement avr gold standard symptomatic aortic stenosis transcatheter procedures proven valid therapeutic option high risk patients aim study compare procedures high risk cohort methodswe retrospectively analyzed symptomatic dyspnea angina high risk patients logistic euroscore fulfilling transcatheter aortic valve implantation tavi indications avr patients operated implementation tavi tavi procedures performed transapically matching age logistic euroscore left ventricular ejection fraction pairs patients evaluated resultswhen comparing avr tavi difference groups survival year kaplan meier analysis log tank complication rates avr tavi stroke acute renal insufficiency atrial fibrillation pacemaker implantation addition quality life differ groups patients tavi group lower mean valvular gradients postoperatively compared avr group conclusionfor high risk patients tavi procedure comparable conventional avr advantageous results support expansion tavi low intermediate risk patients
many bacteria regulate expression virulence factors via carbon catabolite responsive elements gram positive bacteria predominant mediator carbon catabolite repression catabolite control protein ccpa hyperglycemia widespread disorder predisposes individuals array symptoms increased risk infections hyperglycemic individuals bacterium staphylococcus aureus causes serious life threatening infections importance ccpa regulating carbon catabolite repression aureus suggests may important infections hyperglycemic individuals test suggestion hyperglycemic non obese diabetic nod blood glucose level mice challenged mouse pathogenic aureus strain newman isogenic ccpa deletion mutant mst effects infectivity determined diabetic nod mice challenged ccpa deletion mutant enhanced symptoms infection acute murine pneumonia model relative parental strain interestingly diabetic nod mice used footpad catheter infection models infectivity ccpa mutant decreased relative parental strain differences greatly diminished normoglycemic nod mice blood glucose level used data suggest ccpa important infectivity aureus hyperglycemic individuals
emerging internet things opens endless possibilities contemporary notion smart offices employees benefit automations workplace maximize employees productivity enterprise performance however usually integration new components smart environments straightforward article propose use semantic vocabulary define automation architecture consisting web task automation server mobile task automation components enable contextual services one one hand architecture exhibits flexibility interconnect internet services devices side use semantic technologies provides semantic interoperability expressivity automation definition
patients rheumatoid arthritis ankylosing spondylitis increased cardiovascular morbidity mortality arterial stiffness independent predictor events aim study assess arterial stiffness inflammatory markers patients short duration chronic arthritis assessed carotid femoral pulse wave velocity pwv augmentation index aix traditional risk factors inflammatory endothelial markers chronic arthritis patients healthy controls find differences pwv controls respectively versus versus aix controls respectively versus versus groups arthritis patients active disease significantly elevated inflammatory markers compared controls correlations endothelial inflammatory markers parameters arterial stiffness arthritis patients analyzing arthritis patients according median pvw significant differences inflammatory endothelial markers found patients short duration active arterial stiffness increased furthermore association markers systemic inflammation arterial stiffness
many individuals asd distinctive behavioral presentation recognizable within moments phenomenon call frank asd phenomenon discussed informally decades perhaps classic asd however unitary classic presentation classic autism seem correspond level functioning thus neither frank classic autism delineated studied research construct initiate empirical study frank asd surveyed clinicians range disciplines diagnose asd phenomenon respondents completed item questionnaire frank asd analyzed using mixed methods approach ninety seven percentage respondents familiar phenomenon respondents estimated asd population frank presentation respondents reported highly specific behaviors associated frank presentations general sense impaired reciprocity quality eye contact atypical vocal prosody presence motor mannerisms atypical gait posture general respondents reported detecting frank features rapidly majority forming impressions within first ten minutes interaction observation although unstudied empirically frank presentations asd familiar diagnosing clinicians appear based behaviors central asd diagnostic criteria impaired reciprocity absent diagnostic criteria atypical gait posture discuss findings within context diagnostic decision making behavioral phenotyping asd autism res international society autism research wiley periodicals inc autism res international society autism research wiley periodicals inc
although parental attention deficit hyperactivity disorder adhd risk factor multiple negative youth outcomes unknown change parental adhd symptoms time affects change child adhd symptoms moreover mediators predictions largely unknown parents year old children male without adhd followed prospectively years across three separate waves parents self reported adhd depression symptoms similarly rated offspring adhd oppositional defiant disorder odd conduct disorder symptoms youth self reported substance use temporally ordered mediators consisted parental expressed emotion derived five minute speech sample self reported positive negative parenting behavior controlling key demographics parental depression symptoms increasing parental adhd symptoms time varying predictor worsening youth adhd odd although unrelated change alcohol substance use next although facets criticism emotional involvement mediate predictions negative parenting behavior significantly mediated predictions youth adhd marginally predictions odd parental adhd symptoms quasi experimental findings suggest parental adhd symptoms potential unique causal risk factor offspring adhd odd also preventing negative parenting behavior secondary parental adhd symptoms critical improve trajectories youth adhd odd consider parental adhd symptoms family factors underlying emergent externalizing problems utilizing developmental psychopathology framework including implications intervention prevention
study focused views towards emergency contraception among pharmacy attendants greater metropolitan rio janeiro brazil empirical material came socio anthropological study semi structured interviews pharmacy attendants sexes females males interviews showed negative views emergency contraception emphasizing potential health risks interviews considered emergency contraception hormone bomb harm female reproductive organs organ systems pharmacy attendants highlighted risks uncontrolled indiscriminate use especially adolescents young women since considered dangerous women bodies assigned responsibility orientation counseling use method gynecologists rather pharmacists article discusses need expand public debate emergency contraception brazil include pharmacists pharmacy attendants addition health professionals general teachers
work present multi source uncertain entity resolution model show implementation use case yad vashem central repository holocaust era information yad vashem dataset unique respect classic entity resolution virtue massively multi source requiring multi level entity resolution today abundance information sources project motivates use multi source resolution big data scale instantiate proposed model using mfiblocks entity resolution algorithm machine learning approach based upon decision trees transform soft clusters ranked clustering records representing possible entities extensive empirical evaluation demonstrates unique properties dataset make good candidate multi source entity resolution conclude proposing avenues future research realm
semantic memory influenced individual differences conditions distraction question addressed observing participants recalled visual target words drawn single category ignoring spoken distractor words members either different single category working memory capacity wmc related disruption synchronous asynchronous presentation distraction greater words presented synchronously subsequent experiments found greater negative priming distractors among individuals higher wmc may dependent targets distractors comparable category exemplars less dominant category members distractors target recall impaired relative controlonly among individuals low wmc results highlight role cognitive control resources target distractor selection individual specific cost implications cognitive control
nonlinear adaptive filtering techniques system identification based volterra model widely used identification nonlinearities many applications correspondence improved tracking capability numeric variable forgetting factor recursive least squares nvff rls algorithm presented first order second order time varying volterra systems nonstationary environment nonlinear system tracking problem converted state estimation problem time variant system time varying volterra kernels governed first order gauss markov stochastic difference equation upon state space representation system built comparison conventional fixed forgetting factor recursive least squares algorithm nvff rls algorithm provides better channel estimation well channel tracking performance terms minimum mean square error mmse first order second order volterra systems nvff rls algorithm adapted time varying signals using updating prediction error criterion accounts nonstationarity signal demonstrated simulation results manifest proposed method good adaptability time varying environment also reduces computational complexity
background aims kickxia ramosissima wall janch nanorrhinum ramosissimum wall betsche well known medicinal plant pakistan traditionally used diabetic inflammatory conditions little information available phytochemical composition range constituents isolated evaluated vitro assays related traditional use methods dried whole plant material extracted chromatographically fractionated isolated constituents evaluated silico vitro assays related traditional use diabetes inhibition alpha glucosidase activity inhibition advanced glycation endproducts inflammatory conditions inhibition aaph induced linoleic acid peroxidation inhibition lox antimicrobial activity results phytochemical analysis extracts fractions led isolation compounds including iridoids kickxiasine new compound mussaenosidic acid mussaenoside linarioside flavonoids pectolinarigenin pectolinarin hydroxy benzoic acid methyl ester iridoids showed weak antiglycation activity flavonoids however showed interesting results pectolinarigenin highly active compared pectolinarin alpha glucosidase inhibition assay weak activity observed iridoids however flavonoid pectolinarigenin showed good activity followed pectolinarin lox experiment moderate inhibition recorded compounds iridoids mussaenosidic acid mussaenoside active aaph assay weak inhibition recorded compounds silico assays alpha glucosidase lox assays confirmed results respective vitro assays pectolinarigenin showed moderate antimicrobial activity staphylococcus aureus plasmodium falciparum trypanosoma cruzi cytotoxic human mrc cell line conclusion findings may part contribute explain traditional use ramosissima
spin optoelectronics emerging technology novel advanced functionalities enabled synergetic integration magnetic optical electronic properties onto semiconductor based devices article reviews possible implementation convergence spintronics photonics concepts group semiconductors core materials mainstream microelectronics particular describe rapid pace progress achievement lasing action notable case based heterostructures devote special attention pivotal role played optical investigations advancing understanding rich spin physics group materials finally scrutinize recent developments towards monolithic integration new class spin based light emitting devices prospects applications fields cryptography interconnects
identification different loss mechanisms prediction exact power dissipations play significant role development new electric motor designs achievement highest power densities therefore high continuous drive powers many approaches exist estimate ohmic losses windings motor additional mechanical losses bearing losses significant calculation error usually made iron loss estimation stator core paper analytic calculation method iron losses presented gives opportunity predict stator losses without time consuming fem calculations basis calculation model commonly known material parameters lamination sheet insulation varnish well geometric parameters target geometry result loss model compared validated measurement values delivered novel test device stator segments
phase thyristor matrix converter using model predictive control mpc considered compared standard method mpc considers coupled overall system due switching states considered result mpc strategy compared classical control drastic reduction commutation frequency respectively converter losses however besides advantages still problems use mpc thyristor matrix converter therefor contribution presents extensions standard direct model predictive control strategy overcome problems result predictive control structure fallback level problematic working areas low total harmonic distortion thd well high efficiency achieved
keyword search relational databases provides simple interactive query interface retrieving data databases recent year keyword search structured unstructured data received significant attention kws performs enterprise applications based various forms take values values might express verifiable example user identification large portion assortment effort ensures critical confinement connection enterprise information meanwhile neglects application code regularly precisely intended present information significant manner employers lot work done domain many solutions developed still significant limitations perspective enterprise data also performance issues still maintainable updates occur furthermore existing work done around depended making keyword lists indices require modifications maintenance issues raised recent work area light transformed sql inquiries sql queries structure studied existing keyword search techniques compare strength weaknesses discussed flaws imperfections existing work made suggestions improvement future development contrast propose techniques based hybrid approach retrieval information big data made faster using kws agrios minimizes information development two segments hybrid utilizing systems repurposed social database inquiry streamlining therefore information retrieval enhanced proposed technique
objective hereditary angioedema due inhibitor deficiency inh hae rare autosomal dominant disease caused mutations serping gene affect many regions body potentially life threatening laryngeal oedemas concern methods twenty three subjects two families recruited clinical data evaluation molecular analysis general hospital sibenik croatia results decreased levels inhibitor detected adult patients three young asymptomatic persons novel deletion two nucleotides exon delat identified history laryngeal oedema present patients patients reported laryngeal attacks least year delay diagnosis decreased noticeably first last generation conclusions identified novel causative mutation serping several affected members two apparently unrelated families high frequency laryngeal oedema molecular analysis large inh hae families provide new insights genotype phenotype relationship key messageshereditary angioedema due inhibitor deficiency rare autosomal dominant disease caused mutations serping gene laryngeal oedema concern cause death asphyxiation novel causative mutation serping deletion two nucleotides exon delat identified several affected members two apparently unrelated families high frequency laryngeal oedema molecular analysis large inh hae families provide new insights genotype phenotype relationship appears mutation type may affect disease severity
migraine complex debilitating neurovascular disorder typically characterized recurring incapacitating attacks severe headache often accompanied nausea neurological disturbances strong genetic basis demonstrated rare migraine disorders caused mutations single genes monogenic well familial clustering common migraine associated polymorphisms many genes polygenic hemiplegic migraine dominantly inherited severe form migraine associated motor weakness family studies found mutations three different ion channels genes cacnaa atpa scna causal functional studies mutations shown result defective regulation glutamatergic neurotransmission excitatory inhibitory balance brain lowers threshold cortical spreading depression wave cortical depolarization thought involved headache initiation mechanisms putative genes monogenic migraine include kckn prrt csnkd also involved disorders number primarily vascular disorders caused mutations single genes often accompanied migraine symptoms mutations notch causes cerebral autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy cadasil hereditary cerebrovascular disease leads ischemic strokes dementia migraine often present sometimes long onset symptoms mutations trex cola also cause vascular disorders often feature migraine respect common polygenic migraine genome wide association studies identified single nucleotide polymorphisms loci significantly associated migraine risk functions assigned genes proximity loci suggest neuronal vascular pathways also contribute pathophysiology common migraine studies required fully understand findings translate treatment options migraine patients
article presents implementation otsu segmentation method case study using multiple images otsu method performs nonparametric unsupervised image thresholding usually used image segmentation algorithm finds optimal threshold image minimizing within class variance using gray level histogram image proposed implementation conceived emphasizing role mathematics source algorithm design reproducibility research according image processing line ipol philosophy
study examines relationship various aspects female labor participation people family role attitudes following exposure theory expect individuals may adopt egalitarian family roles often exposed employed women dispels negative ideas women capabilities brings contact nontraditional networks study provides elaborate test examining role exposure female colleagues supervisors three contexts workplaces occupational sectors countries found number female colleagues work occupational sectors positively related egalitarian family roles employed men study showed positive relationship exposure female colleagues work men egalitarian family roles weaker female dominated sectors remarkably exposure national female labor participation significantly related family roles employed women
large class functions group points elliptic curve typically obtained certain algebraic correspondences farashahi math comput established map regular sense uniformly random choice elliptic curve point close uniformly distributed result several applications cryptography mainly construction elliptic curve valued hash functions elligator squared technique tibouchi christin safavi naini eds financial cryptography lncs vol springer heidelberg representating uniform points elliptic curves close uniform bitstrings paper improve upon farashahi character sum estimates two ways show regularity also obtained function form much smaller domain prove functions considered farashahi also satisfy requisite bounds restricted large intervals inside improved estimates used obtain efficient hash function constructions well much shorter elligator squared bitstring representations
context modern software systems often distributed run virtualized platforms implement complex tasks operate dynamically changing unpredictable environments systems need dynamically reconfigured evolve order continue meet functional non functional requirements load computation need change reconfiguration evolution actions may cause requirements fail objective given models describe degree confidence requirements hold running software system along inter dependencies objective propose framework process models estimate degree requirements hold system dynamically altered adapted method present approach requirements inter dependencies modeled using conditional goal models weighted contributions models translated fuzzy rules fuzzy reasoners determine whether degree requirement may affected system change actions related requirements results proposed framework evaluated performance stability goal models varying size complexity experimental results indicate approach tractable even large models allows dealing models contribution links varying importance weight conclusion use conditional weighted goal models combined fuzzy reasoners allowed tractable run time evaluation degree system requirements believed hold systems dynamically altered adapted approach aims shed light towards development run time requirements verification validation techniques adaptive systems systems undergo continuous frequent evolution elsevier rights reserved
background sixty years ago diabetes almost non existent greenland beginning century awareness diabetes quite minimal high prevalence undiagnosed diabetes reported repeated population surveys increased focus diabetes made priority within health care system since glycated haemoglobin introduced diagnostic tool facilitate diagnosis diabetes objective aim study estimate age gender specific use glycated haemoglobin indicator diagnostic activity awareness diabetes estimate prevalence diagnosed pre diabetes diabetes among adults greenland aged years age methods study performed observational cross sectional register study based information gleaned electronically laboratory system used greenland including patients tested glycated haemoglobin least results total patients tested glycated haemoglobin corresponding whole population among adults aged years patients tested corresponding total adult population females males aged years old tested prevalence diagnosed diabetes high risk pre diabetes among adults aged years respectively conclusion conclusion use glycated haemoglobin widely used health care system greenland indicating high awareness diabetes population health care system still awareness undiagnosed diabetes remains important issue additional strategies targeting males years old must considered
background new industrial postgraduate professional degree education china research object qingdao university science technology control engineering pilot based cdio concept framework professional degree education ability form round three dimensional select appropriate professional knowledge ability training course system teaching mode achieve outline training target let students teacher guidance help play subjective initiative training students various abilities makes market knowledge skills technical application creative talents
accessible summary compassion focused therapy talking therapy helps people kind know whether therapy help people learning disabilities talk happened man learning disability therapy hope people use therapy improve therapy people learning disabilities abstract background joe referred community learning disabilities team cldt support around low mood overeating initial formulation suggested compassion focused therapy cft intervention evidence base using cft people learning disabilities currently limited materials methods adaptations made cft framework accounting joe learning disability case study design used investigate effectiveness intervention joe attended sessions assessment formulation intervention client feedback incorporated assess suitability cft approach adaptations made results conclusions changes scores outcome measures limited however findings exploratory study suggest cft meaningfully adapted use within field learning disabilities implications clinical practice directions future research discussed
beliefs unacceptability experiencing expressing emotions found related worse outcomes people persistent physical symptoms current study tested mediation models regarding emotional suppression beliefs emotions support seeking global impact fibromyalgia one hundred eighty two participants took part online questionnaire testing potential mechanisms relationship using mediation analysis model tested emotional suppression affective distress serial mediators relationship beliefs emotions global impact parallel paths two forms support seeking tested personal emotional symptom related support seeking mediators emotional suppression affective distress significantly serially mediated relationship beliefs emotions global impact neither support seeking variable significantly mediated relationship results indicate potential mechanism beliefs emotions global impact might relate might provide theoretical basis future research treatments fibromyalgia
memory tested researchers often interested items correctly recalled recognized ignoring factoring trials one recalls recognizes nonstudied item however intrusions false alarms nuisance data provide key insights memory system present article reports experiments demonstrating people remarkably consistent rate incorrectly report memory nonstudied items even across range differing stimuli test features experiment found individual differences false alarms intrusions strongly related even controlling shared influence memory ability incorrect response types furthermore intrusion rate found related response bias well effect suppressed shared influence memory ability demonstrating independent measure memory ability important control investigations individual differences response bias experiment revealed relations intrusions false alarm rate response bias entirely explained one ability discriminate episodic memories semantic generation work links together previous work individual differences intrusions false alarms highlights ability identify source memory key cognitive trait underlying incorrect response styles various memory tests
treatment highly concentrated industrial dye stuff effluents released enviromnent major issue faced era waste management well water pollution though availability conventional techniques large numbers need efficient effective advance technologies account nanoteclmology plays prominent role treat heavy metals organic inorganic contaminants using smart materials nano regime among nanomaterials like iron oxide feo magnetic nanoparticle one promising candidates remove heavy metals industrial effluent feo widely used smart material magnetic property high surface area high surface volume ratio provides surface chemical reaction surface adsorption feo nanoparticles synthesized using sonochemical method using ultra frequency aqueous solution optimized conditions synthesized nanoparticle analyzed using different characterization tool transmission electron microscope tem images revealed inn spherical shape nanoparticles crystal phase surface morphology confirmed ray diffraction xrd scanning electron microscopy sem respectively functional group identified fourier transform infra red spectroscopy revealed bending stretching vibrations associated iron oxide nanoparticle present study efficient removal contaminants different concentration ppm dye stuff effluent prepared subjected adsorption decolourization definite time intervals feo nanoparticles concentration iron oxide time mins kept fixed reaction whereas concentration dye stuff effluent kept varying found spherical shaped feo proved potential material adsorption corresponding contaminants due highly active adsorbing surfaces result concluded effective adsorption decolourization contaminants observed different concentration maximum time period ruins optimized concentration feo
using hopf bifurcation theory nonlinear dynamic characteristics hydro turbine governing system hydropower station upstream surge tank sloping ceiling tailrace tunnel studied firstly novel rational nonlinear mathematical model hydro turbine governing system proposed model contains nonlinear dynamic equation pipeline system accurately describe motion characteristics interface free surface pressurized flow sloping ceiling tailrace tunnel according nonlinear mathematical model existence direction hopf bifurcation nonlinear dynamic system analyzed furthermore algebraic criterion occurrence hopf bifurcation derived stability domain bifurcation diagram hydro turbine governing system drawn algebraic criterion finally dynamic characteristics different state parameters investigated dynamic control method proposed results indicate example paper hopf bifurcation hydro turbine governing system supercritical phase space trajectories characteristic variables stabilize equilibrium points stable limit cycles system state parameter point locates stable domain unstable domain respectively dynamic response processes characteristic variables hydro turbine governing system load disturbance show obvious feature wave superposition make dynamic response process hydro turbine governing system upstream surge tank sloping ceiling tailrace tunnel stable attenuate faster governor parameters locate stable domain keep away bifurcation point much possible
background administrative claims united states centers medicare medicaid services cms beneficiaries long used non experimental research cms performs house checks claims little known quality conducting pharmacoepidemiologic research performed exploratory analyses quality medicaid medicare data obtained cms contractors methods study population consisted medicaid beneficiaries without dual coverage medicare california florida new york ohio pennsylvania obtained compiled data state medicaid programs constituting nationwide medicaid enrollment together corresponding national medicare data dually enrolled beneficiaries descriptive study examined longitudinal patterns dispensed prescriptions state quarter inpatient hospitalizations federal benefit state age group examined discrepancies demographic characteristics disease states particular frequencies pregnancy complications among men women beyond childbearing age prostate cancers among women results dispensed prescriptions generally increased steadily consistently time suggesting claims may complete commercially available national drug code lookup database able identify dispensed drug claims coverage medicare medicaid data appeared miss substantial number hospitalizations among beneficiaries years age pregnancy complication diagnoses rare males females years age prostate cancer diagnoses rare females conclusions cms claims five large states obtained directly cms contractors appeared high quality researchers using medicaid data study hospital outcomes obtain supplemental medicare data dual enrollees even non elders
article new exact travelling wave solutions nonlinear space time fractional burger nonlinear space time fractional telegraph nonlinear space time fractional fisher equations found based nonlinear fractional complex transformation certain fractional partial differential equations turned ordinary differential equations integer order sense jumarie modified riemann liouville derivative expansion method effective constructing solutions nonlinear fractional equations appears easier convenient means symbolic computation system copyright john wiley sons ltd
ethnopharmacological relevance chang kang fang formula ckf multi herb traditional chinese medicinal formula clinically used treatment irritable bowel syndrome ibs mechanisms ckf treating ibs components responsible activities still unknown aim study investigate chemical profiles effects ckf ibs model materials methods chemical profiles ckf investigated ultra performance liquid chromatography coupled quadrupole time flight mass spectrometry uhplc tof colon irritation induced rat neonates ibs model influence ckf neuropeptides including substance calcitonin gene related peptide cgrp vasoactive intestinal polypeptide vip hydroxytryptamine measured elisa effect intestinal sensitivity assessed based abdominal withdrawal reflex awr scores addition activities ckf acetic acid induced nociceptive responses prostigmin methylsulfate triggered intestinal propulsion mice also evaluated results components identified tentatively assigned ckf including alkaloids flavanoids monoterpenoids iridoid glycoside phenylethanoid glycosides chromones organic acid coumarins triterpene compounds ibs rat model ckf observed reduce awr scores levels cgrp vip moreover ckf reduced acetic acid induced writhing scores dosages reduced intestinal propulsion ration dosage conclusions ckf could alleviate symptoms ibs modulating brain gut axis increasing production neuropeptides cgrp vip releasing pain reversing disorders intestinal propulsion berberine paeoniflorin acteoside flavonoids chromones may responsible multi bioactivities ckf
recent social scientific research potential negative effects viewing media violence focused context violence depicted found ways depicting violence may carry greater risks negative effects viewers others research compared motion picture production code restrictions depictions film violence amazing degree overlap two despite fact time code written research existence drafters could rely
supervised unsupervised satellite image classifications progressed greatly recent years however discrimination difficulties still remain among classes directly affecting data extraction surface mapping accuracy ouargla region southeastern algeria intersected wadis direct communication shallow groundwater table dry overlying ephemeral stream beds exists underflowing groundwater exfiltrates low lying aeolian blowouts endorheic basins forming oases chotts sebkhas commonly known saline wetlands wetlands becoming increasingly vulnerable anthropogenic stress resulting significant water degradation wetland microclimates important arid regions promote oasis ecosystem sustainability preservation high water salinity ecosystems however directly affects flourishing habitat undermines successful desert oasis development objective work choose best classification method identify saline wetlands comparison different results land use mapping within ouargla basin landsat etm satellite imagery using visual analysis colored compositions identified various forms saline wetlands ouargla region desert environment southeast algeria results show supervised classification validated identification saharan saline wetlands support vector machine svm algorithm presents best overall accuracy
background injury prevention highly needed physically active populations pre service service physical education teachers pets lack adherence preventive strategies problematic injury seems crucial develop optimize interventions correspond specific needs wishes pets aim purpose present study fourfold specifically aimed systematically optimizing injury prevention intervention pets based teachers qualitative evaluation intervention quantitatively investigating whether appreciation injury prevention intervention higher optimization examining whether participation intervention resulted positive changes teachers perceived utility confidence apply proposed preventive strategies well knowledge strategies describing teachers adherence proposed preventive strategies engaging intervention participants twenty pets men mage years nine different secondary schools flanders belgium voluntarily participated study intervention based findings continuing professional development cpd literature principles self determination theory took place two different training days training training consisted seven intrinsic injury prevention strategies data collection analysis qualitative data teachers appreciation intervention collected means focus group interviews used optimize intervention aim quantitative data teachers appreciation collected directly engaged intervention used compare appreciation initial optimized versions trainings aim means repeated measures anovas positive evolutions teachers belief utility confidence apply knowledge provided strategies across time examined aim finally teachers adherence evaluated relying weekly online registrations minutes types preventive strategies teachers practised past week aim findings despite relatively high initial appreciation scores optimized versions trainings scored better interaction intelligibility innovation practical usefulness recommendation aims significant differences found time terms within teacher changes perceived utility confidence apply knowledge preventive strategies aim finally prospective registrations teachers adherence proposed strategies showed mean time min week balanced distribution different strategies aim conclusions present study developed intervention optimally fulfils wishes needs target population namely pets readily implemented pet education programmes cpd programmes service pets results pilot study promising teachers displayed increases several relevant outcomes various suggestions formulated increase pets appreciation cpd programmes
many jumping interventions performed children adolescents order improve bone related variables thus ensure healthy bone development periods later life systematic review aims summarize update present knowledge regarding effects jumping interventions may bone mass structure metabolism order ascertain efficacy durability duration effects caused intervention interventions identification studies performed searching database medline pubmed sportdiscus additional studies identified contacting clinical experts searching bibliographies abstracts search terms included bone bones jump weight bearing resistance training school intervention search conducted october studies performed specific jumping intervention year olds measured bone mass included independent extraction articles done authors using predefined data fields total studies included review twenty four studies found positive results subjects included intervention groups showed higher bone mineral density bone mineral content bone structure improvements controls two studies found effects bone mass week month intervention moreover studies evaluated durability effects found increases intervention groups maintained several years jumping interventions childhood adolescence improve bone mineral content density structural properties without side effects type interventions therefore implemented possible order increase bone mass early stages life may direct preventive effect bone diseases like osteoporosis later life
many variants particle swarm optimization pso algorithm proposed literature past two decades two research major topics namely particle movement trajectory analysis parameter selection also intensively explored focused two issues paper transforms velocity updating strategy pso algorithm incremental pid controller thus develops new incremental pid controlled search strategy endow new pid controlled deterministic search strategy stochastic nature mutation operation applied particles exemplars based learning concepts novel incremental pid controlled pso called ipid pso short algorithm proposed proposed ipid pso algorithm applied eight benchmark problems function optimization widely considered literature compare two pso variants ipid pso algorithm outperforms eight functions superiority shows usefulness proposed search strategy finally ipid pso employed estimate parameters jiles atherton model usually adopted describe hysteresis loop magnetic materials results demonstrate proposed ipid pso also effective model parameter estimation therefore concluded ipid pso algorithm provides promising satisfactory solution real world applications
hereditary angioedema hae patients experience recurrent local swelling various parts body including painful swelling intestine life threatening laryngeal oedema hae literature attacks located one anatomical site though mentioned hae attacks may also involve multiple anatomical sites simultaneously detailed description multi location attacks currently lacking study investigated occurrence severity clinical course hae attacks multiple anatomical locations hae patients included clinical database recombinant human inhibitor rhcinh studies evaluated visual analog scale scores filled patients various symptoms various locations investigator symptoms scores attack analysed data eligible attacks patients analysed thirty three patients symptoms multiple locations anatomically unrelated regions time first attack five simultaneously affected locations reported observation severe hae attacks often affect multiple sites body suggests hae symptoms result systemic rather local process currently believed
paper realization low power portable low cost multi sensor system air water quality monitoring described developed system batterypowered solar panel based charger unit intended use remote environmental monitoring collecting information air temperature relative humidity presence volatile organic compounds voc well water temperature level hardware system based atmega microcontroller acquires sensors data coordinates work peripherals establish full standalone operation peripherals tft color lcd display embedded keypad card data storage included air quality parameters collected sht voc sensors water temperature monitored encapsulated sensor level monitoring tio based thick film resistive sensor fabricated characterized sensor readout electronics based integrated circuit designed way ensure reliable situ measurements discussion applications proposed system complex cloud based system air water quality monitoring real time ibm watson iot platform given well
facial expressions always attracted considerable attention form nonverbal communication visual applications movies games animations people tend interested exaggerated expressions rather regular expressions since exaggerated ones deliver vivid emotions paper propose automatic method exaggeration facial expressions motion captured data certain personality type exaggerated facial expressions generated using exaggeration mapping transforms facial motions exaggerated motions individuals identical personalities conceptual mapping individual personality type exaggerating facial expressions needs considered myers briggs type indicator popular method classifying personality types employed define personality type based experimentally validated simulations facial expressions
paper presents new methodology design multivariable smith predictor nxn processes multiple time delays based centralised inverted decoupling structure controller elements calculated order achieve good reference tracking decoupling response independent system size simple general expressions controller elements obtained realisability conditions provided particular case processes elements first order plus time delay systems discussed detail diagonal filter added proposed control structure order improve disturbance rejection without modifying nominal set point response obtain stable output prediction unstable plants effectiveness method illustrated different simulation examples comparison works
study conducted buffalo embryos fetuses starting day day frontal parietal interparietal upper part squamous occipital formed desmocranium parietals located roof skull throughout prenatal life frontals parietals showed dome like appearance prenatal stages occurrance interparietals inconstant ossification desmocranium first appeared frontal days early ossification parietal noticed days bone wise sequence appearance ossification frontal parietal interparietal upper part squamous occipital
report discovery small phenyl molecule four isosteric thiolate reactive groups sequentially varied reactivity molecule exploited combination cysteine penicillamine thiolates different nucleophilic reactivity precisely regulated efficient locking prop locking linear peptides multicyclic topologies one pot reaction prop locking relies multistep sequential thiolate fluorine nucleophilic substitutions rapid highly specific thus enabling rapid locking peptides high amino acid diversities without protecting groups several tricyclic peptide templates bioactive peptides designed synthesized using proplocking strategy believe tricyclic peptides precisely locked stable thioether bonds promising structurally constrained scaffolds developing potential therapeutics target ligands
patients pelvic organ prolapse pop may present large combination symptoms including active bladder oab symptoms urgency frequency urgency incontinence explanation symptoms prevalent pop patients clearly understood seems overall agreement prolapse induced bladder outlet obstruction boo may trigger bladder changes resulting oab symptoms presuming true many studies managing oab pop patients focused surgical management prolapse aftermath many patients leads improvement oab symptoms review presents recent studies evidence looking management oab face pop seeks evaluate association prolapse severity oab symptoms
paper parallel coupled optical ring resonator filter studied transfer function derived using signal flow graph sfg approach identify filter performance terms crosstalk suppression bandwidth signal integrity paper proposes use sfg mason rule approach determine filtering characteristics parallel coupled ring resonators commercial electromagnetic simulator used validate analytical model modeling parallel coupled ring resonator covers analysis band rejection ratio crosstalk suppression loss effect effect coupling coefficients crosstalk bandwidth good agreement analytical model results simulation results suggests using derived analytical model provides accurate starting point design analysis provides better insight signal integrity performance filter
charities often circulate widespread donation appeals likely donate appeals impact well individual donors non donors well entire group exposed campaign investigate three factors may influence donations recent winnings presence another person matched earnings addition changes affect reported individuals donate response charitable opportunity critically also investigate change affect reported entire sample measure net impact donation opportunity results reveal people winning money donate smaller percentage charity presence another person influence giving addition large donors experience hedonic boosts giving substantial fraction large donors translates net positive influence well entire sample
paper describes macromodel operational amplifiers compressor circuit design macromodel allows simulate operational amplifier singlepower supply well double power supply output waveforms using macromodel compared using pre set model double power supply output voltages using present macromodel amplified region less input voltages compressed region larger hand output voltages using pre set model constantly amplified whole region found macromodel take account behavior single power supply suitable simulating compressor circuits
knowledge growth models based primary principles play fundamental role cognitive sciences authors submit extension model enki results practical testing performed using method developed purpose model enki solving tasks immediate feedback applied curriculum parallel configuration resistors electrical circuits pupils six elementary schools attendance testing analysis based enki indicates three autonomous units scopes evaluated simultaneously assessment results showed pupils knew curriculum pupils showed improvement pupils showed increased success accordance enki model significance level alpha solving typical tasks average method immediate feedback resulted pupils mastering curriculum
soil moisture one essential climate variables global climate observing system gcos prioritized esa climate change initiative construct homogeneous long term climate record requires consistent characterization error structures individual data sets vary due changes instrument configuration calibration retrieval algorithm design paper random error systematic differences nine passive active microwave satellite soil moisture products australia time coverage present estimated manner components subseasonal seasonal interannual timescales separately multi scale error structures found non trivial vary products giving cause conducting multi scale merging awareness differences noticeable similarities error structures satellite products derived retrieval algorithm measuring frequency however suggest transferability error parameters using partial rank correlation analysis error maps linked statistics vegetation index digital elevation soil moisture soil temperature land cover fractions mixing order explain observed variability similarities products elsevier inc rights reserved
medial tibiofemoral joint contact forces estimated using musculoskeletal models assess change forces accompany load modifying interventions minimum detectable change mdc thresholds must established primary study purpose derive mdcs medial tibiofemoral peak force force impulse walking secondary purpose identify proportions individuals exhibiting reductions greater mdcs walking lateral foot wedging eight healthy individuals provided dimensional gait data test sessions serve inputs inverse dynamics driven medial tibiofemoral contact force model mdcs peak force impulse derived mdc peak force impulse healthy individuals provided gait data walking without degrees laterally wedged foot orthoses proportion individuals exhibiting changes medial tibiofemoral contact peak force impulse values exceeding mdc threshold determined impulse peak force participants exhibited decrease exceeding mdc respectively summary medial tibiofemoral contact force mdcs derived impulse showing greater sensitivity peak force effects biomechanical intervention
purpose robust empirical evidence illustrated rising prevalence body dissatisfaction disordered eating among males noting may oriented toward muscularitydas opposed thinness oriented concerns elevated prevalence premorbid anorexia nervosa noted among muscle dysmorphia little evidence examined process transition thinness oriented muscularity oriented disordered eating methods clinical observation presents case adolescent male whose symptom presentation transitioned course treatment muscularity oriented disordered eating results despite core body image disturbance disordered eating behaviors retained behavioral expression muscularity oriented disordered eating difficult detect treatment discharged treatment muscularity oriented disordered eating escalated conclusions transdiagnostic crossover thinness oriented muscularity oriented disordered eating represents important clinical concern may challenging measure assess implications treatment discussed early detection muscularity oriented disordered eating society adolescent health medicine rights reserved
aim study develop evaluate low cost automation system management different fertigation regimes tomato plants solanum lycopersicum grown protected environment system consisted irrigation controller coupled substrate moisture sensors programmable logic controller plc four water regimes nutrient supply levels considered evaluations developing functional tests performed automation system moreover cost benefit analysis assembling system carried result noted automation system efficient controlling fertigation showed problems regarding malfunction still presenting lower cost compared commercial controllers
canadian digestive disease foundation renamed canadian digestive health foundation fondation canadienne pour promotion digestive december culmination ongoing efforts canadian association gastroenterology establish independent charitable organization february officially endorsed foundation canadian association gastroenterology initial efforts establish foundation led richard mckenna unsuccessful glaxo canada glaxosmithkline became founding donor four founding physicians drs ivan beck richard hunt suzanne lemire alan thomson expenses establish foundation met charitable number obtained second founding donor janssen canada janssen ortho public education support came astra canada astrazeneca canada foundation initially relied corporate donors approaches physicians patients general public objectives foundation advance science gastroenterology provide knowledge digestive diseases nutrition general public enhance quality life persons afflicted disorders major achievements foundation provision one year operating grants new investigators allowed accumulate early data subsequently obtain support major granting organizations also provides fellowships studentship support grants conjunction canadian institutes health research pharmaceutical industry education committee found little research support field considering large economic burden digestive disease amount outstanding work done canadian researchers bilingual web site web based specialist discussion program bilingual pamphlets facilitate public awareness allow patients voice concerns
paper presents numerical experimental tests innovative wave energy conversion wec system extracting electrical power waves consists point pivoted floater oscillates due waves linked buoyant body electromechanical generator based ball bearing screw converts floating movements electrical power first analytical description system arrangement presented experimental tests scaled model performed wave towing tank facility data tests used comparison data numerical simulations potential flow unsteady reynolds averaged navier stokes urans numerical simulations performed simulations performed order identify critical parameters wec developments elsevier ltd rights reserved
purpose renewable energies promoted order reduce greenhouse gas emissions depletion fossil fuels however plants renewable electricity production incorporate specifically higher amounts materials rated potentially scarce therefore question mineral resources contribute overall resource consumption manifold impact assessment methods recommended cover accurate complete investigation resource use renewable energy technologies methods life cycle assessment conducted different renewable electricity production technologies wind photovoltaics biomass german conditions compared fossil electricity generation coal fired power plant focus given mineral resource depletion technologies consensus reached far impact assessment method recommended different established well recently developed impact assessment methods cml recipe swiss ecoscarcity economic scarcity potential esp compared contribution mineral resources overall resource depletion well potential scarcity identified results discussion overall resource depletion electricity generation technologies tends dominated fossil fuel depletion therefore renewable technologies reduce overall resource depletion compared coal fired power plant comparison fossil electricity generation coal mineral resource depletion increased wind solar power investigated methods rate different materials major contributors mineral resource depletion gallium used photovoltaic plants swiss ecoscarcity gold copper incorporated electrical circuits cables cml recipe nickel swiss ecoscarcity recipe chromium esp stainless steel production however methods lack characterization factors potentially important materials conclusions mineral resource use investigated technologies using wider spectrum potentially scarce minerals practitioners need choose impact assessment method carefully according scope check important materials covered research needed overall assessment different resource compartments
background child abuse often unrecognized hours primary care ooh services aim study evaluate clinical outcome screening instrument sputovamo child abuse checklist followed structured approach reporting code ooh services reporting code five steps ensure consistent action case suspicion methods children attending one five participating ooh services region utrecht netherlands year time included checklist obligatory field electronic patient file filled children case positive checklist steps reporting code followed additionally case evaluated multidisciplinary team determine probability child abuse results checklist filled children positive multidisciplinary team diagnosed child abuse positive checklists child abuse emotional neglect frequent type abuse diagnosed abused children care implemented according protocol frequent care given referral hospital contact child general practitioner conclusion checklist followed reporting code guarantees consistent actions care children suspicion child abuse percentage positive checklists lower expected validity checklist assessed diagnostic study
background osteoarthritis prevalent disease articulating joints complex multifactorial disease caused genetic mechanical environmental factors research evaluated mirna expression methods forty tissue samples patients undergoing joint replacement evaluated tissue two control patients undergoing hip replacement related used control total rna containing mirna species cartilage isolated using mirvana mirna isolation kit expression mirnas assessed real time quantitative polymerase chain reaction results expression four mirnas mir mir mir mir significantly upregulated tissues patients control group conclusions findings may contribute disease prevention development therapeutic targets
experimentally well known overpotentials oxygen evolution reaction oer ruo iro similar rather low question whether widespread computational electrochemistry models based adsorption thermodynamics capable reproducing observations making use dft results revised perdew burke ernzerhof rpbe perdew burke ernzerhof pbe functionals six different codes various types pseudopotentials show whereas iro consistently predicted low overpotentials ruo predicted large overpotentials new methodology based adsorption energy scaling relations shows inaccurate prediction ruo stems anomalous adsorption energies oxygen oxygenates including explicit water solvation using functionals account van der waals interactions vdw vdw optpbe vdw modifies appropriately adsorption energies oxides predicted highly active
aimpast hepatitis virus hbv infection considered risk factor hepatocarcinogenesis clinicopathological characteristics non non hepatocellular carcinoma nbnc hcc excluding past hbv infection investigated study aimed clarify clinicopathological features strictly defined nbnc hcc methodsamong hcc patients underwent surgical resection affiliated hospitals nagano prefecture japan negative serum anti hbv core surface antibodies addition hbv surface antigen anti hepatitis virus antibody without signs autoimmune liver disease wilson disease hemochromatosis patients divided alcohol intake positive group ethanol intake day non alcoholic fatty liver group steatosis ethanol intake day cryptogenic group ethanol intake steatosis preoperative clinical parameters tumor background liver pathology prognosis analyzed resultsadvanced fibrosis steatosis detected patients respectively approximately alcohol intake positive patients advanced fibrosis non alcoholic fatty liver hcc subjects highest body mass index prevalence diabetes none mild fibrosis cryptogenic group hcc patients lowest incidence accompanying hepatic inflammation fibrosis largest tumor size recurrence survival rates comparable among groups conclusionsliver fibrosis steatosis risk factors hcc regardless past hbv infection ethanol consumption present results also indicate possibility hepatocarcinogenesis independent hepatic steatosis inflammation fibrosis ethanol intake past hbv infection
paper novel lorentz force driven planar motor low force ripple proposed magnetic field distribution calculated analytically using magnetic surface charge model image method expressions force torque derived based lorentz force law method electromagnetic design motor also discussed static force characteristic measured experimentally experiment results good agreement results analysis simulation
functional abilities cdkl disorder described severely impaired yet individuals able run use phrases speech study investigated gross motor hand function expressive communication abilities individuals cdkl disorder data females males registered international cdkl disorder database pathogenic cdkl mutation analyzed relationships functional abilities age genotype gender analyzed using regression models half females could sit floor nearly quarter could walk steps fewer males could complete tasks although one boy able sit walk run females males able pick large object females mostly used gestures communicate males mostly used forms nonverbal communication compared functional cdkl protein individuals truncating variants likely able stand walk independently use advanced communication methods words although abilities markedly impaired majority cdkl disorder females males better functional abilities variability may related underlying gene variants females late truncating variant better levels ability functional protein wiley periodicals inc
methamphetamine meth widely abused stimulant drug abuse associated increased risk developing psychosis addition well known action brain dopamine meth also affects serotonergic neurons aim study investigate role mice lack one main serotonin receptors hta receptor implicated schizophrenia meth induced psychosis male female wild type hta knockout mice received daily treatment increasing doses methamphetamine weeks age day twice day least weeks last injection mice underwent battery behavioral tests focusing psychosis related behaviors including meth induced hyperactivity prepulse inhibition ppi social interaction elevated plus maze epm maze meth pretreatment resulted significantly increased hyperlocomotion response acute meth challenge effect independent genotype chronic meth treatment resulted decreased levels anxiety epm sexes well increased startle responses female mice independent genotype hta mice showed increased locomotor response acute meth sexes well increased ppi decreased startle responses female mice independent meth pretreatment conclusion effects chronic meth appear unaffected absence hta receptor results support role hta receptor meth induced psychosis
big data era process large scale data stream one existing challenges feature extraction method attracted much attention effectiveness data classification traditional classification algorithms may take less advantage labeled samples information online learning sample problems also hot topics recently solve problems novel algorithm named semi supervised incremental feature extraction algorithm proposed paper first extract feature incrementally unsupervised way propose semi supervised subspace learning algorithm taking advantage class information adjust nearest neighbor weights third combine unsupervised semi supervised feature extraction approaches obtain objective function order solve sample learning problem experiments carried machine learning datasets university california irvine uci datasets real world face image datasets olivetti faces orl yale yaleb rendered face demonstrate proposed algorithm expandability process large scale data stream classification experiments using spark skill parallel computation environment performed comparisons related semi supervised feature extraction methods experiment results computational complex comparison demonstrate proposed algorithm obtain good performance copyright john wiley sons ltd
polish university comply national qualification framework ministry science higher education new competences defined accordance principles bologna process include information literacy warsaw university technology currently implementing process library efforts accepted mainly first year students get credits departments training obligatory training help year students become acquainted whole range possibilities offered library two chemistry departments wut cooperate library information literacy program addressed postgraduate students support specific courses learning three years ago information literacy also implemented phd curriculum four hours lectures may summer semester also refworks ecourse obligatory authors present experiences creating implementing blended learning information literacy several departments wut last year course overview sources field chemistry related sciences course addressed students chemistry chemical engineering materials engineering medical engineering environmental engineering biotechnology course refworks addressed library users groups students faculty librarians authors would like demonstrate library moodle platform could used support complement course curriculum platform practical means promoting enhancing students use information resources warsaw university technology also plans develop basic advanced level information literacy future introducing blended learning
water scarcity imperfect consumption patterns rapid global population increase surpassing consumption ratio several factors overstress urging necessity systematically access utilize supplementary importantly renewable water supply resources moreover application suitably designed well maintained rainwater harvesting systems within context built environment generalizing focus diverse building typologies promoted promising resolution systemic issues despite numerous positive benefits utilizing rainwater harvesting means supporting sustainable development green built environments exists gap properly integrating design features deliver congruent sustainable outcomes accurate design configuration simulation localization imposing proper maintenance schemes expected followed order accomplish ultimate goal executing rainwater harvesting systems besides inevitable noteworthy role governments educating providing prospects supporting decentralized water supply consumption systems encouraged ultimately paper provides overview contemporary rainwater harvesting systems respective implications systematic configurations quality assessments potential rightfully merging green roofs green built environment criteria eventually manipulated government regulation provide insights overcoming aforementioned intensifying rainwater related concerns
study sought prospectively predict aggression romantic relationships college students united states females males course two months set intrapersonal risk protective factors including personality characteristics rarely examined population accounting prior dating aggression perpetration verbal aggression predicted uniquely aggressive attitudes emotion regulation females narcissism perpetration physical aggression predicted aggressive attitudes low levels emotion regulation interaction callous unemotional traits emotion regulation gender males low levels callous unemotional traits perpetrated less physical aggression reported greater emotion regulation findings among first show personality traits emotion regulation prospectively predict partner aggression late adolescence suggest mechanisms continuity interpersonal aggression early adolescence adulthood foundation professionals services adolescents published elsevier ltd rights reserved
autism heterogeneous multifactorial disease results interaction genetic vulnerability environmental factors several studies showed many genes play role autism component signaling networks regulate growth synaptic plasticity play important role etiology autism contactin associated like cntnap gene member superfamily synaptic adhesion proteins encodes scaffold protein called caspr involved interaction neuron glia clusters channels myelinated axons cntnap highly expressed nervous system development study association cntnap gene polymorphism autism investigated two hundred patients autism healthy individuals included study genomic dna extracted peripheral blood cells genotypes analyzed polymerase chain reaction restriction fragment length polymorphism pcr rflp statistical analysis performed using software medcalc genotype frequencies controls values patients autism respectively frequency alleles patients controls respectively results study showed significant association cntnap gene polymorphism autism studied population however obtain definitive conclusion larger studies patients controls needed confirm results elsevier ltd rights reserved
present paper deals defect detection diagnosis induction motor based motor current signature analysis quality control scenario order develop monitoring system improve reliability induction motors clarke concordia transformation kernel density estimation employed estimate probability density function data related healthy faulty motors kullback leibler divergence identifies dissimilarity two probability distributions used index automatic defects identification kernel density estimation improved fast gaussian transform since techniques achieve remarkable computational cost reduction respect standard kernel density estimation developed monitoring procedure became applicable line quality control method end production line test several simulations experimentations carried order verify proposed methodology effectiveness broken rotor bars connectors simulated experimentations carried real motors end production line results show proposed data driven diagnosis procedure able detect diagnose different induction motor faults defects improving reliability induction machines quality control scenario elsevier ltd rights reserved
study aims investigate weight regain associated variables years roux gastric bypass retrospective study recruited patients submitted roux gastric bypass year follow following variables investigated body mass index bmi percentage excess weight loss ewl weight regain percentage weight regain chi squared test fisher exact test compared proportions mann whitney test compared numerical measurements groups analysis variance anova compared measurements time significance level set sample mean age years females prevailed long term follow patients weight regain seventy two months surgery excess weight preoperative bmi gender age nutritional monitoring iron deficiency explain weight regain younger patients regained significantly weight months surgery older patients patients regained weight ferritin months surgery patients submitted roux gastric bypass presented weight regain increased time age iron deficiency time since surgery associated weight regain long term follow
omega chicken egg chicken egg produced food engineering technology produced hen fed high omega fatty acids fifteen times nutrient content omega higher leghorn visually shell shape colour leghorn egg distinguished breaking egg shell testing egg yolk nutrient content laboratory methods proven effective efficient observing problem purpose research make application detect type omega chicken egg using mobile based computer vision application built opencv computer vision library support android operating system experiment required chicken egg images taken using egg candling box used omega chicken leghorn eggs samples using android smartphone image acquisition egg obtained applied several steps using image processing methods grab cut convert rgb image eight bit grayscale median filter tile segmentation morphology technique research next steps feature extraction used extract feature values via mean variance skewness kurtosis image finally using digital image measurement chicken egg images classified result showed omega chicken egg leghorn egg different values system able provide accurate reading around
recently political economic educational contacts people republic china slovak republic intensified chinese language taught slovak university agriculture since order overcome cultural limits international business negotiations concentrate attention cross cultural communication chinese slovak managers successful negotiations require careful consideration cultural differences business etiquette article focus behaviour meetings verbal nonverbal communication including useful suggestions slovak chinese negotiators involved intercultural business negotiations
practall joint initiative american academy allergy asthma immunology european academy allergy clinical immunology provide shared evidence based recommendations cutting edge topics field allergy immunology practall focused established regarding role microbiome patients asthma atopic dermatitis food allergy complemented outlining important knowledge gaps regarding role allergic disease delineating strategies necessary fill gaps addition review progress approaches used manipulate microbiome addressed identifying worked serve baseline future directions intervene allergic disease development progression
estimating grid admittance essential assessing impedance stability designing adaptive controllers distributed generation units paper proposes new multivariable grid admittance identification algorithm involves adaptive model order selection ancillary function within inverter based controllers cross coupling axis grid admittances necessitates multivariable estimation ensure persistence excitation grid admittance sensitivity analysis first employed order determine injection controlled voltage pulses grid admittance estimated processing extracted grid dynamics refined instrumental variable method continuous time system identification rivc algorithm theoretical background underlying rivc algorithm introduced along integration within proposed method adaptive model order selection unlike nonparametric identification algorithms proposed rivc algorithm provides parametric multivariable model grid admittance essential designing adaptive controllers hardware loop application using opal real time simulators used validate proposed algorithm grid connected isolated active distribution networks
background inclusion schools students autism spectrum disorder asd source stress teachers requires certain amount adaptation deal effects perceived self efficacy burnout professionals substantiated indirect effects mediated transactional processes stress coping never explored specific context study aims test mediating effect perceived stress coping strategies relationship perceived self efficacy burnout method sample teachers students asd filled four self report questionnaires measuring perceived self efficacy perceived stress coping strategies burnout multiple mediation analysis carried using bootstrap procedure results controlling direct effect perceived self efficacy burnout indirect effects transactional processes significant lower teachers feeling self efficacy implemented emotion focused coping strategies predict higher burnout three dimensions moreover lower teachers feeling self efficacy perceived stressful situation question threat loss perceptions generate emotional exhaustion conclusion results enable formulate ideas improving wellbeing teachers working students asd management students thus learning abilities wellbeing school elsevier ltd rights reserved
background graphical presentation analysis motif distribution provide insights experimental hypothesis pisma aims identifying motifs dna sequences counting showing graphically motif length ranges bases dna sequences range motif distribution shown bar code like gene map like transcript scheme results obtained graphical schemes cpg site distribution human papillomavirus genomes also present analyses one dna motifs associated either methylation resistant methylation sensitive cpg islands another analysis motifs associated exosome rna secretion availability implementation pisma developed java executable type hardware diverse operating systems pisma freely available noncommercial users english version user manual provided supplementary files spanish version available www biomedicas unam content software pisma zip www biomedicas unam content pdf manual pisma pdf
background investigated differences prevalence anosognosia neuropsychiatric symptoms npss characteristics according disease severity patients early onset alzheimer disease eoad methods recruited patients eoad subdivided participants groups based presence absence anosognosia clinical dementia rating cdr scale compared differences neuropsychiatric inventory npi scores according anosognosia disease severity results percentage patients anosognosia cdr group steadily increased cdr rating increased cdr cdr cdr npi total score significantly higher patients anosognosia cdr groups contrast association cdr group frontal lobe functions associated anosognosia cdr groups stratification cdr cdr group prevalence agitation appetite significantly higher patients anosognosia cdr group patients anosognosia significantly higher prevalence delusions hallucinations sleep disturbances cdr group found statistical difference frequency symptoms patients without anosognosia conclusion results confirm prevalence anosognosia well individual nps cognitive functions associated differ according eoad severity
requirement prioritization considered crucial towards development successful high quality software nowadays software development project people software industries confronted challenge implementing large scale complex dynamic software applications hence need use requirement prioritization technique able deliver right set requirement seems crucial available techniques still suffer several weaknesses motivate identify comprehensively limitations future directions existing requirement prioritization techniques study conducted depth software engineering based systematic literature review helps execute thorough fair literature review due predefined review protocol gathered list requirement prioritization techniques investigate limitation weaknesses one technique findings study later used design new effective efficient requirement prioritization technique
motivated collaborative study one comprehensive ocular imaging programs united states investigate underlying three way trade among operational clinical financial considerations physicians decisions ordering imaging tests laboratory tests may processed parallel thus limited effect patients waiting times imaging tests contrast require patient presence thus directly influence patients waiting times use strategic queueing framework model physician decision ordering imaging tests show insurance coverage key driver overtesting analysis reveals following whereas existing studies hold lower pocket expenses lead higher consumption levels refine statement showing copayment coinsurance rate drive consumption different directions thus simply expanding patient cost sharing solution overtesting setting low reimbursement ceiling alone eliminate overtesting iii joint effect misdiagnosis concerns insurance coverage lead overtesting undertesting even reimbursement ceiling exists results continue hold general conditions therefore robust enrich model along two extensions one patient heterogeneity diagnostic precision disparities health insurance coverage findings implications healthcare settings similar trade offs
mucormycosis lethal opportunistic fungal infection described mostly immunocompromised patients comparative cohort study conducted compare evolution study group patients rhino orbital mucormycosis therapeutic protocol instituted pterygomaxillary fossa systematically surgically approached orbital exenteration performed based spreading infection orbital apex orbital fissure historical group criteria applied fifteen cases included eight historic group seven study group medical treatment provided control underlying disease amphotericin low molecular weight heparin well surgical treatment extensive debridement including endoscopic ethmoidectomy exploration pterygomaxillary fossa also performing orbital exenteration patients presented orbital apex syndrome group group mortality rate group patients clinical cured however two patients hematologic diseases died complications related fungal infection standardization diagnostic therapeutic protocol good results healing survival patients obtained
background ethanol photosynthetic production based cyanobacteria cell factories utilizing solar energy provides attractive solution sustainable production green fuels however scaling processes cyanobacteria cell factories usually threatened even devastated biocontaminations restricted biomass products accumulations cyanobacteria cells thus great significance develop reliable bio contamination controlling strategies promoting ethanol photosynthetic production large scales results scaling process previously developed synechocystis strain syn ethanol synthesis severely inhibited devastated specific contaminant pannonibacter phragmitetus overcame growths cyanobacteria cells completely consumed ethanol accumulation cultivation systems physiological analysis revealed growths ethanol consuming activities contaminant sensitive alkaline conditions ethanol synthesizing cyanobacteria strain syn could tolerate alkaline conditions high indicating increasing strategy might feasible approach rescuing ethanol photosynthetic production outdoor cultivation systems thus designed evaluated bicarbonate based integrated carbon capture system biccs derived rising strategy rescue ethanol photosynthetic production non sterilized conditions lab scale artificially simulated systems values culture medium maintained around nahco air steam infection pannonibacter phragmitetus significantly restricted recovering ethanol production syn outdoor cultivations ethanol photosynthetic production syn also successfully rescued biccs derived rising strategy obtaining final ethanol concentration days cultivation conclusions work novel product consuming biocontamination pattern cyanobacteria cultivations causing devastated ethanol photosynthetic production identified characterized physiological analysis essential ethanol consuming contaminant directed design application rising strategy effectively selectively controlled contamination rescued ethanol photosynthetic production work demonstrated importance reliable contamination control systems strategies large scale outdoor cultivations cyanobacteria provided inspiring paradigm targeting effective solutions
moral decision making linked empathy present study built previous work examining relationship psychopathy autism spectrum disorder asd two conditions putatively associated deficits empathy utilitarian decision making students scoring high self report measures psychopathic autistic traits presented novel task utilitarian judgments compared low trait control groups study replicated classic finding direct links agents actions harm victims mitigated utilitarian decision making also found participants made utilitarian decisions outcomes involved extreme physical versus everyday social harm enhanced utilitarian decision making observed scoring high either psychopathic autistic traits although high trait groups reported would experience less discomfort low trait counterparts verbal reasoning differences observed high autistic trait group high psychopathic trait group dilemmas typically used explore utilitarian decision making describe extreme hypothetical events involving physical serious emotional harm present findings suggest might limit generalisability existing literature emphasise tendency make utilitarian decisions considering everyday dilemmas
intranasal administration hypothalamic neuropeptide oxytocin studies associated positive effects social perception cognition similarly positive emotion inductions improve range perceptual performance based behaviors exploratory study examined administration positive emotion inductions interact associations social analytical performance participants randomly assigned receive intranasal spray placebo viewed one three videos designed engender one following emotion states social warmth pride affectively neutral state following emotion induction participants completed social perception analytical tasks significant main effects condition social perception tasks failing replicate prior research analytical performance condition positive emotion inductions interact associations social perception performance however condition positive emotion manipulations significantly interact associations analytical performance specifically combining positive emotion inductions administration associated worse analytical performance pride induction longer benefiting performance warmth induction resulting worse performance sum found little evidence main interactive effects social perception preliminary evidence administration may impair analytical performance paired positive emotion inductions elsevier inc rights reserved
background develop new strategies identifying atopic dermatitis patients better understanding signs chronic inflammatory status needed study designed investigate whether neutrophil lymphocyte ratio nlr platelet lymphocyte ratio plr related severity atopic dermatitis assessed scoring atopic dermatitis scorad index material methods retrospective study involving patients healthy control subjects performed nlr plr number peripheral blood eosinophils compared patients healthy controls correlations indexes clinical characteristics analyzed results nlr plr eosinophils patients significantly higher healthy individuals among patients nlr plr contrasted eosinophils correlated positively scorad index additionally nlr level determined predictive cut value severe scorad sensitivity specificity area receiver operating characteristic curve auroc eosinophils sensitivity specificity respectively auroc predicting high scorad conclusions nlr plr reflect inflammatory response disease severity patients
investigated quantitative imaging reduced scattering coefficients lambda absorption coefficients lambda vivo cortical tissues range visible near infrared nir wavelengths based diffuse reflectance spectral imaging technique method diffuse reflectance images vivo cortical tissue acquired nine wavelengths multiple regression analysis aided monte carlo simulation absorbance spectra utilized estimate optical coefficients cortical tissue analysis calculates concentration oxygenated hemoglobin deoxygenated hemoglobin scattering amplitude scattering power spectrum absorption coefficient deduced estimated concentrations oxygenated hemoglobin deoxygenated hemoglobin spectrum reduced scattering coefficient determined estimated scattering amplitude scattering power particle size distribution microstructure calculated estimated scattering power evaluating morphological change brain tissue quantitatively animal experiments vivo exposed brain rats demonstrated responses absorption properties hyperoxic anoxic conditions agreement expected well known cortical hemodynamics average particle size significantly reduced immediately onset anoxia changed increase implied swelling shrinkage cellular subcellular structures induced loss tissue viability brain tissue
background patients type diabetes increased risk osteoporosis even insulin therapy adult stage study conducted compare efficacy hesperidin hesp therapy versus insulin alone alleviation osteoporosis arising type diabetes mellitus tdm young rats materials methods hesperidin administered orally stz induced diabetes animals evaluated morphologically biochemically compared received daily injections long acting insulin results histologically observed degeneration osteoblasts osteocytes decreased collagen fibers disturbed bone turn markers untreated rats hesperidin insulin supplementation diabetic rats caused significant improvement bone histological morphometric parameters compared insulin treated group furthermore hesp treatment significantly reduced pro inflammatory mediators tnf alpha kappa increased serum biochemical markers bone turnover including osteopontin opn osteocalcin decreased serum alkaline phosphatase alp conclusion data demonstrated hesp could considered beneficial drug preventing diabetic osteoporosis growing age elsevier gmbh rights reserved
model proposed calculating composition gaasxp solid solutions based iterative determination equilibrium partial pressures pyrolysis products starting reagents followed calculation composition solid solution adsorption desorption model proposed model ensures good agreement calculation results experimental data
high dimensional time series data wide variety domains neuroscience generated every day fitting statistical models data enable parameter estimation time series prediction important computational primitive existing methods however unable cope high dimensional nature data due computational statistical reasons mitigate kinds issues proposing estimator reduced rank system identification sid combination low rank approximations penalties numerical linear algebra tricks yields estimator computationally efficient numerically stable simulations real data examples demonstrate usefulness approach variety problems particular demonstrate sid accurately estimate spatial filters connectivity graphs time courses native resolution functional magnetic resonance imaging data sid therefore enables big time series data analyzed using standard methods readying field generalizations including nonlinear non gaussian state space models authors published elsevier
traceability supports various activities software development process impact analysis changes reuse maintenance verification validation graphical representation traceability information important effective use activities visualization tools help interaction large amount data identification characteristics patterns trends however visualization tools usually built specific domain generally support single visualization technique therefore meet appropriately needs different contexts paper presents tool support traceability visualization provides different visualization techniques allowing user choose appropriate task evaluation results proposed tool presented two studies
compare nature determinants child discipline qatar palestine among young adults retrospective survey develop legislation policies interventions effective prevention child maltreatment educational materials promote positive discipline among parents caregivers cross sectional random household surveys conducted country qataris palestinians using ispcan child abuse screening tool retrospective icast young adults years investigate child discipline methods maltreatment range qatari young adults educated full time employment palestinian young adults qatar reported lower physical emotional abuse compared counterparts palestine hit punch kick insult criticize threaten hurt killed qatari participants found harsh discipline received childhood reasonable justified compared palestinian participants advantaged qatari population less likely experience disciplinary methods experts developing icast defined abuse compared palestinians higher incidence child abuse could attributed lower economic advantage lower level education greater exposure violence suggestions made future studies qatar palestine develop survey methodology culturally appropriate level intrusion indirect yet meaningful child maltreatment questions elsevier ltd rights reserved
current computer programs intracellular recordings often lack advanced data management usually incompatible applications also difficult adapt new experiments addressed shortcomings phys suite electrophysiology applications intracellular recordings programs phys use component object model com technologies available microsoft windows operating system provide enhanced data storage increased interoperability phys com aware applications easy customization data acquisition analysis thanks script based integrated programming environment data files extensible hierarchically organized integrated windows shell using structured storage technology data transfers programs facilitated implementing activex automation standard distributed com dcom activex scripting allows experimenters write event driven acquisition analysis programs vbscript language within phys scripts reuse components available programs machines create distributed meta applications paper describes main features phys package used determine effect atypical antipsychotic drug clozapine synaptic transmission neuromuscular junction elsevier rights reserved
guiding attention emotional responses little girl darkly lit surroundings jude film explores human existence face death informed existential philosophy vein heidegger article investigates difference fear death fear dead
link schizophrenia families genetically isolated south african afrikaner population chromosome combined patients linkages chromosome times likely meet diagnostic criteria schizoaffective disorder compared patients linkage third patients linkage met diagnostic criteria sad significant positive relationship suicidality diagnosis schizoaffective disorder identifying linkage chromosome may informative identifying suicide risk early prevent morbidity mortality schizophrenia patients
pervious concrete special type concrete high porosity use pervious concrete may achieve many potential leed green building rating system credits objective paper investigate appropriate mix proportion provides high leed points also good mechanical properties nine mix proportions based possible leed points examined replacement cement fly ash coarse aggregate recycled aggregate used properties pervious concrete relating leed credits design values permeability void content compressive strength splitting tensile strength evaluated found proposed pervious concrete achieve stormwater design quantity control recycled content recycled materials credits according results mix proportions cement replaced fly ash archived highest leed credit points also provided sufficient mechanical properties therefore mix proportions recommended green construction
numerous studies show individuals substance use gambling problems discount delayed probabilistic outcomes different rates controls studies however investigated association discounting antisocial personality disorders aspd none evaluated whether sex impacts relationships females aspd exhibit different patterns antisocial behavior male counterparts may also differ decision making tendencies study examined effects aspd sex discounting pathological gamblers results revealed effects aspd interaction aspd sex probability discounting rates none variables however related delay discounting females aspd highly preferred probabilistic outcomes suggesting female gamblers aspd particularly impulsive comes probabilistic rewards greater understanding sex differences aspd might help guide selection effective sex specific prevention treatment programs
background morbidity estimates different registration networks show large unexplained variations research explores potential modeling differences networks distinguishing new incident cases existing prevalent cases obtaining reliable estimates methods data five dutch registration networks data four chronic diseases chronic obstructive pulmonary disease copd diabetes heart failure osteoarthritis knee used joint model dismod model fitted using information morbidity incidence prevalence mortality network including factor misclassification prevalent cases incident cases results observed estimates vary considerably networks using disease modeling including misclassification term improved consistency prevalence incidence rates systematically decrease variation networks osteoarthritis knee showed large modeled misclassifications especially episode care based registries conclusion registries code episodes care rather disease generally provide lower estimates prevalence chronic diseases requiring low levels health care osteoarthritis diseases modeling misclassification rates systematically decrease variation registration networks using disease modeling provides insight reliability estimates
large number medications medical devices removed market food drug administration past decades specifically posed greater health risks women article reviews historical background sex gender clinical research policy describes several approved drugs devices targeted use women caused major morbidity mortality intended population medications devices population affected approval process basic legal actions taken medication drug company also discussed recognized women still risk harm unsafe medications devices continued improvements legislation promotes inclusion sex gender design analysis research improve safety men women elsevier journals inc rights reserved
paper proposes numerical method accurate time domain noise simulation mixed analogue digital electrical circuits principle admit periodic steady state working condition fractional sigma phase locked loops plls means tool known saltation matrix allows dealing non smooth vector fields variational approach adopted power spectral density noisy electrical variable computed applying thomson multitaper method mtm numerical solution stochastic variational model circuit allows resort single transient simulation run thus avoiding cpu time consuming monte carlo like approaches effectiveness proposed method shown comparing simulation results related commercial fractional sigma pll experimental data
theory research media violence provides evidence aggressive youth seek media violence media violence prospectively predicts aggression youth authors argue relationships modeled time mutually reinforcing call downward spiral model study uses multilevel modeling examine individual growth curves aggressiveness violent media use measure use media violence included viewing action films playing violent computer video games visiting violence oriented internet sites students middle schools different regions united states findings appear largely consistent proposed model particular concurrent effects aggressiveness violent media use concurrent lagged effects violent media use aggressiveness found implications model theorizing media effects youth bridging active audience media effects perspectives discussed
background leadership process individual influences group individual achieve common goal case health promotion individuals disabilities objectives examine association transformational leadership behaviors association university centers disabilities aucd network professionals practice beliefs health promotion activities specifically cardiovascular fitness healthy weight people disabilities determine discipline years practice moderate association transformational leadership behaviors practice beliefs regarding health promotion hypothesis positive association transformational leadership behaviors health professionals practice beliefs regarding health promotion activities persons disabilities methods quantitative cross sectional web based survey design used determine association leadership behaviors practices beliefs regarding health promotion people disabilities multifactor leadership questionnaire adapted version role health promotion physical therapy survey used measure leadership practice beliefs respectively multiple regression analysis applied determine association leadership behaviors health promotion practice beliefs variables results transformational leadership behaviors aucd network professionals positively associated health promotion practice beliefs cardiovascular fitness people disabilities years post licensure discipline moderate association transformational leadership practice beliefs regarding health promotion conclusion transformational leadership may facilitate health professionals health promotion practices people disabilities research training leadership needed elsevier inc rights reserved
objective social skills play important role employment study provides qualitative analysis salient work related social skills interventions addressing social skills public vocational rehabilitation research design modified consensual qualitative research cqr approach taken understand elements influence work related social skills public thirty five counselors supervisors administrators participated semistructured interviews provide perspectives work related social skills interventions use addressing skills results multiple aspects work related social skills described important consumer success common work related social skills across participants nonverbal communication ability connect others primary social interventions included informal social skills training sst systems collaboration creating appropriate job match conclusions public rehabilitation agency staff constantly faced addressing work related social skills possess many insights salient skills interventions benefit future research practice agencies currently address social skills deficits providing interventions person environment research provides directions future research related identification social skills interventions address related deficits
drinking non bovine milk reported possess bio functionality regular consumers camel milk traditional product used many years arid rural communities asia africa biomedicine cure several health issues asthma oedema diabetes product consists appropriate amounts bioactive compounds addition contains low amounts fatty acids cholesterol whilst contain beta lactoglobulin latter present bovine milk causes allergic symptoms people similarity formula human milk suggests superfood alternative bovine milk complete nutrition infants review biomolecules present camel milk positive roles health consumers extensively discussed crown copyright published elsevier ltd rights reserved
test octogenarians treadmill exercise myocardial perfusion imaging exercise mpi risk stratify large artery chronic cad related ischemic stroke laccis exercise mpi related data octogenarians prior revascularization without previous stroke registered prospective follow performed document laccis laccis defined acute onset neurological symptoms mri findings non lacunar type infarcts absence atrial fibrillation intracardiac embolic sources years laccis documented sss cis sds cis non sustained transient block exercise cis predictors laccis sss threshold specificity identification future laccis risk groups formed according cut significantly different laccis free survival exercise mpi octogenarians provide risk stratification markers laccis
statistics finance real estate literature regularly rely propensity score matching techniques balance samples data randomized treatment assignment possible sustainable commercial real estate literature technique seen substantive use analyze price rent premiums green buildings several studies used propensity scores ensure samples contains eco labeled labeled buildings reflect randomized assignment treatment underpinning argument use propensity scores notion green buildings contain similar attributes non green buildings however green labels ignored would premium buildings otherwise statistically similar premium buildings market analyze research question focusing extent propensity scores predict green building using standard building attributes whether propensity scoring econometric necessity
background immunoassays criticized poor accuracy low testosterone concentrations mass spectrometry proposed reliable method testosterone determination aim study compare sensitive testosterone radioimmunoassay ria results different methods compared testosterone concentrations determined sensitive testosterone ria lower limit detection nmol limit quantitation nmol four tandem included international external quality assessment program laboratory medicine also compared morning concentrations testosterone girls boys different pubertal stages using results ria reported values determined developed androgen determination children results mean concentrations similar ria child women range nmol nmol adult male range nmol respectively ratio ria versus results mean values four methods child women concentrations male testosterone concentrations furthermore compared pediatric reference values determined sensitive testosterone ria delivered similar testosterone values across different pubertal stages conclusions comparison different tandem methods sensitive testosterone ria illustrates immunoassays deliver clinically useful information prepubertal pubertal children
wilkerson gupta allen keith colston utilization practice session average inertial load quantify college football injury risk strength cond res relatively studies investigated potential injury prevention value data derived recently developed wearable technology measurement body mass accelerations performance sport related activities available evidence derived studies focused avoidance overtraining syndrome believed induce chronically fatigued state identified monitoring inertial load accumulation reduced variability movement patterns also believed important injury risk factor evidence currently exists guide interpretation data derived inertial measurement units imus regard retrospectively analyzed archived data cohort national collegiate athletic association division football bowl subdivision football players wore imus upper back practice sessions quantify associations average inertial load measured practice sessions occurrence musculoskeletal sprains strains coefficient variation average inertial load frequent exposure game conditions found strongly associated injury occurrence either risk factors provided strong discrimination injured noninjured players odds ratio findings may facilitate identification individual football players likely derive greatest benefit training activities designed reduce injury risk improved adaptability rapidly changing environmental demands
introduction patients anaplastic lymphoma kinase alk rearranged non small cell lung cancer nsclc may derive significant clinical benefit targeted therapies driver mutation progression virtually inevitable alectinib next generation alk inhibitor provides novel treatment option group patients areas covered review summarize overall safety tolerability alectinib specifically cover cardiovascular gastrointestinal hepatic musculoskeletal respiratory adverse events safety profile alectinib also described special populations comparison alk inhibitors expert opinion alectinib well tolerated tyrosine kinase inhibitor considered patients alk rearranged nsclc question arises choose next generation alk inhibitor second line setting understanding acquired resistant mechanisms become essential whether use alectinib first line setting extremely controversial anticipate approval indication availability countries near future
introduction amyloid imaging integrated diagnostic criteria alzheimer disease amyloid tracers binding differ different tracer structures amyloid beta aggregates autosomal dominant adad sporadic unclear methods binding properties different amyloid tracers examined brain homogenates six adad appswe delta mutations sporadic control cases results pib florbetaben azd bta shared high varying low affinity binding site frontal cortex sporadic azd detected another binding site affinity frontal cortex adad azd pib binding significantly higher striatum adad compared sporadic control polyphenol resveratrol showed strongest inhibition azd binding followed florbetaben minimal pib discussion study implies amyloid tracers different structures detect different sites amyloid beta fibrils conformations alzheimer association published elsevier inc rights reserved
idiopathic pneumonia syndrome ips noninfectious inflammatory disorder lungs occurs often fully myeloablative allogeneic hematopoietic stem cell transplantation hsct ips severe associated high year mortality rates despite existing therapies canonical nuclear factor signaling pathway previously linked several inflammatory disorders lung including asthma lung allograft rejection never specifically targeted novel ips treatment approach however report kappa kinase ikk antagonist bay compound highly potent specific inhibitor kappa pathway able improve median survival times recipient oxygenation well described mouse model ips compound impaired production proinflammatory chemokines ccl ccl within host lung transplantation resulted significantly lower numbers donor lung infiltrating cells reduced pulmonary inflammatory cytokine production allograft compound beneficial effects appeared specific limiting pulmonary injury drug unable improve outcomes haplotype matched murine hsct model recipient mice succumb lethal acute graft versus host disease gastrointestinal tract collectively data suggest targeting canonical kappa pathway small molecule ikk antagonist may represent effective novel therapy specific management acute lung injury occur allogeneic hsct american society blood marrow transplantation
wind energy generated wind power plentiful renewable clean available many places world energy generated wind turbines wind captured propellers connected turbine drives electrical generator use source generate electricity commercial scale began international oil crisis escalated european countries became interested development alternatives production electricity sources seeking reduce dependence oil coal use wind power generate electricity drawbacks however uncertainties generation difficulty planning operation power system several models wind power forecasting using artificial neural networks presented promising results paper presents use ensemble approach improve results obtained models using artificial neural networks specifically reservoir computing reservoir computing new paradigm offers intuitive methodology using temporal processing power rnns without inconvenience training main issue using ensemble approach consideration accuracy diversity individual predictors constitute ensemble
enhanced version segmentation algorithm applied ray images using prior shape straightened boundary image sbi proposed sbi method boundary target object extracted constant width along prior shape transformed rectangular image edges straightened new minimal path algorithm proposed applied sbi minimising cost function select best path corresponding edges target object cost function calculated based possible paths pixel beginning image lowering computational complexity comparing previous methods proposed method removes artefacts provides clearer smoother edges even prior shape far target object method also less sensitive initial positioning prior shape model
central infusion atpase inhibitor ouabain rats serves animal model mania leads hyperactivity well reproduces ion dysregulation reduced brain derived neurotrophic factor bdnf levels similar observed bipolar disorder bipolar disorder also associated cognitive inflexibility working memory deficits unknown whether ouabain treatment rats leads similar cognitive flexibility working memory deficits present study examined effects intracerebral ventricular infusion ouabain rats spontaneous alternation probabilistic reversal learning bdnf expression levels frontal cortex ouabain treatment significantly increased locomotor activity affect alternation performance maze ouabain treatment selectively impaired reversal learning spatial discrimination task using probabilistic reinforcement procedure reversal learning deficit ouabain treated rats resulted impaired ability maintain new choice pattern increased regressive errors ouabain treatment also decreased sensitivity negative feedback initial phase reversal learning expression bdnf mrna protein levels downregulated frontal cortex also negatively correlated regressive errors findings suggest ouabain model mania may useful understanding neuropathophysiology contributes cognitive flexibility deficits test potential treatments alleviate cognitive deficits bipolar disorder article part special issue entitled cognitive flexibility ibro published elsevier ltd rights reserved
study rotary valve system rvs automotive engines carried many years recent researches already successfully implemented idea none design provide variable valve timing flow area control simultaneously therefore rvs variable valve control system proposed paper system design dynamic analysis proposed rvs first presented moreover selection proportional integral derivative pid controller parameters valve control based emerging artificial intelligent technique cuckoo search also discussed experimental simulation results show proposed tuning method better traditional ziegler nichols method proposed variable rotary valve control system feasible
fungal diseases emerging important public health problem worldwide increase host predisposition factors due immunological dysregulations immunosuppressive anticancer therapy antifungal therapy systemic mycosis limited times expensive causes important toxic effects nanotechnology become interesting strategy improve efficacy traditional antifungal drugs allows lower toxicity better biodistribution drug targeting promising results vitro vivo review provide discussion conventional antifungal nanoantifungal therapies systemic mycosis
using qualitative research one organization undertook green building examine processes occur foster support new initiative among people diverse values perceptions found framing particularly important framing contests occurred due variation individuals cognitively connected different frames together overcome contests organization used interactive process define frame decoupling frames identified separated prioritized new language frame selected collective organizational goal develop concept frame decoupling describe variations cognitive diagnostic framing stakeholders within organization contribute framing contests contests resolved interactive processes effectively decouple various preexisting frames frame decoupling additional frame alignment strategy social movements organizations use motivate support action organizational goals
paper draws attention fundamental problem version tracing strategy defended number theorists current literature rosen philos perspect fischer tognazzini noa argue versions tracing strategy require reasonable foreseeability rather actual foresight tension view blameless ignorance excuses stronger version tracing strategy one requires actual foresight consistent view blameless ignorance excuses therefore preferable tracing theorists wish continue maintaining
dopamine key neurotransmitter induces critical effects nervous system many peripheral organs via dopamine receptors drs dopamine also induces many direct potent effects many expressing immune cells primarily cells dendritic cells review focus dopamine receptors effects production cells dopamine optimal concentration similar induces multiple function resting normal human cells among cell adhesion chemotactic migration homing cytokine secretion others interestingly dopamine activates resting effector cells teffs suppresses regulatory cells tregs effects lead eventually teff activation dopamine induced effects cells dynamic context sensitive determined cell activation state cell type type dopamine concentration dopamine also dopaminergic molecules drugs clinical use cardiac neurological non immune indications direct effects human cells summarized review dopaminergic drugs include dopamine intropin dopa bromocriptine pramipexole pergolide haloperidol pimozide amantadine dopaminergic drugs yet tested direct effects cells extensive evidence multiple sclerosis experimental autoimmune encephalomyelitis eae show dopaminergic dysregulations cells diseases like drs decreased teffs patients dopamine affect cells contrast like drs increased tregs patients possibly causing functional treg impairment treatment patients interferon beta ifn beta increases like drs decreases like drs teffs decreases like drs tregs important restores responsiveness patient teffs dopamine agonists antagonists confer benefits eae afflicted animals single clinical trial patients benefit bromocriptine like agonist nevertheless multiple evidence showing dopaminergic abnormalities cells encourages testing analogues drugs possibly add ifn beta immunomodulating therapies together abnormalities drs cells contribute drs cells therapeutic targets finally general scope direct effects dopaminergic drugs human cells studied depth also taken consideration whenever treating patients disease avoid detrimental side effects immune system patients
electric field coupled power transfer ecpt systems proposed alternative wireless power transfer wpt technology recent years use capacitive plates coupling structure ecpt systems many advantages design flexibility reduced volume coupling structure metal penetration ability addition wireless communications effective solutions improve safety controllability ecpt systems paper proposes power signal shared channel electric field coupled power transfer systems shared channel includes two similar electrical circuits band pass filter signal detection resistor designed based traditional current fed push pull topology analysis mutual interference power signal transmission channel power signal attenuations dynamic characteristic signal channel conducted determine values electrical components proposed shared channel experimental results show designed channel transfer output power data data rate bps kbps
increasing attention environment impacts activities companies phenomena arise many industrial sectors regarding construction property industries last decades acknowledgement responsibilities environment caused shift buildings designed built operated requirement always innovative sustainable technologies materials buildings takes shape two different point view global construction industry basis two different orientations world construction sector would found divergent demand developed developing countries measurement environmental performance new existing buildings fundamental weigh effects potential improvements building energy regulations last decades many building performance assessment tools developed order sustain green building philosophy leadership energy environmental design leed system considered one popular green building certification program used worldwide developing countries scenario many tools rose leed system one reference framework researches paper purpose short review researches role buildings energy regulations developing countries development building performance assessment tools colombia qatar jordan aim analysis purpose integration building rating value brave system existing tools developed developing countries brave system would contribute upgrade variables used comprehensive evaluation building thank application cross disciplinary criteria embrace different thematic scientific areas authors published elsevier ltd
introduce new representation inverted index performs faster ranked unions intersections using similar space index based treap data structure allows intersect merge document identifiers simultaneously thresholding frequency instead costlier two step classical processing methods achieve compression represent treap topology using different alternative compact data structures treap invariants allow elegantly encode differentially document identifiers frequencies also show extend representation support incremental updates index results show idf scoring scheme index uses space state art compact representations performing times faster ranked single word union intersection queries scoring scheme index may use space others outperforms less frequently still reaches improvement factors best cases index supporting incremental updates poses overhead static variants terms space construction query time
consider exact sampling stationary distribution closed queueing network finite capacities recent work compact representation sets states proposed enables exact sampling stationary distribution without considering initial conditions coupling past cftp scheme representation reduces complexity one step transition cftp algorithm number queues total number customers cardinality state space exponential number queues paper extend previous results multiserver case main focus contribution paper algorithmic implementation issues propose new representation leads one step transition complexity cftp algorithm provide detailed description matrix based implementation matlab toolbox clones closed queueing networks exact sampling downloaded http www ens similar rovetta clones elsevier rights reserved
biofilm acts stabilising river bed sediments interfering particle entrainment consequently preventing bed disturbance paper present results series experiments carried indoor channels aimed understand biofilm alteration bed material motion topographic changes stream channels analysed erosion patterns bedload rates non cohesive sediments channels colonised biofilms compared biofilm free others channels conditions light irradiance temperature slope particle size sand discharge water surface slope modified create range hydraulic conditions pairs colonised non colonised channels subjected flows observed biofilm slightly modified bed roughness flow hydraulics highly influenced bed disturbance biofilm caused bed scour occur patches unevenly distributed along channel length result localised weaknesses biofilm biofilm ripped transported chunks sand grains observed attached chunks non colonised sediments erosion homogeneous formation movement bedforms observed average bedload rates times lower biofilm present overall protective effect biofilm prevented generalised erosion channel delayed entrainment transport sand grains results emphasised important role biofilm incipient motion bed material stream channels role may affect magnitude frequency subsequent river bed processes notably onset bedload associated channel morpho dynamics elsevier rights reserved
paper presents method detection series arc faults electrical circuits developed starting experimental characterization arc fault phenomenon arcing current study several test conditions starting authors found possible suitably detect arc faults means high resolution low frequency harmonic analysis current signal based chirp zeta transform proper set indicators proposed method effectiveness shown means experimental tests carried arcing nonarcing conditions presence different loads chosen according standard requirements
electric vehicle charging loads may challenge grid stability due combination high charging power temporal clustering charging activity hence charging needs coordinated appropriately prior work addressing challenge focused static charging strategies responding exogenous price vectors extend work two directions achieve endogenous resource pricing substitute exogenous pricing local market platform allocates available charging capacity demand evs achieve meaningful interaction market model bidding behavior evs means learning approach using integrated trip based state space representation spanned required battery level time departure moderate bidding aggressiveness mobility requirements appropriate learning parameters bidding behavior converges market achieves significant load shifting
mindfulness practice cultivation awareness present moment shown recent years beneficial effects cognition however date data regarding impact mindfulness memoryand specifically memory distortionsis scarce incomplete present study aimed examine whether mindfulness practice would effect true false memories end effect mindfulness meditation practice memory performance examined two experiments false memories provoked using deese roediger mcdermott drm paradigm roediger mcdermott experiment college students randomly divided either week mindfulness practice group waitlist control group experiment college students randomly divided either brief mindfulness session mind wandering control group results indicated mindfulness increased recognition true memories effect spontaneous false memories yet increased rate provoked false memories findings discussed terms memory sensitivity response bias argued mindfulness may lesser effect encoding processes previously suggested
background previous diffusion tensor imaging dti studies consistently shown subjects cocaine use disorder cocud altered white matter microstructure corpus callosum believed alterations due preexisting factors chronic cocaine use however published longitudinal dti study human cocaine users yet could shed light relationship cocaine use dti findings methods study used longitudinal design dti test white matter microstructure shows quicker alteration cocud subjects controls dti data acquired eleven cocud subjects participated treatment study eleven non drug using controls baseline scan ten weeks scan baseline fractional anisotropy general measure white matter microstucture change delta equals scan minus scan compared groups results two groups show difference baseline cocud subjects significantly greater delta controls left splenium corpus callosum cocud subjects greater region associated shorter lifetime cocaine use greater number positive cocaine urine samples collected treatment conclusion finding left splenium consistent previous animal studies provide indirect evidence effects chronic cocaine use white matter alterations subject sample size small therefore results treated preliminary elsevier rights reserved
water key risk resource improved water management essential terms quantity two major alternatives water management grouped improving efficiency water use exploring alternative water sources rainwater harvesting rwh one promising alternative water sources since rainwater easily collected used without significant treatment non potable purposes however economical viability systems always assured paper examines relevant technical economical issues designing domestic rwh systems evaluating technical feasibility economical viability technology particular weather water use portugal evaluation performed single family residence water use pattern monitored precipitation pattern characterized two locations portugal porto almada since represent two different scenarios rwh rwh water savings efficiency assessed payback period estimated cities found optimum rainwater tank water savings potential similar locations despite differences average annual precipitation simple rule estimating optimum tank capacity single family households portugal proposed sensitivity analysis shows important influence water fees economical viability rwh systems single family houses portugal namely compared changes consumption pattern elsevier rights reserved
recent increased interest computational thinking poses important question researchers best ways teach fundamental computing concepts students visualization suggested one way supporting student learning mixed method study aimed examine effect instruction students constructed visualizations students programming achievement students attitudes toward computer programming explore kind instruction supports students learning according self reported experiences course study conducted pre service teachers enrolled second programming class expect teach information technology computing related courses primary secondary levels embedded experimental model utilized research design students experimental group given instruction required students construct visualizations related sorting whereas students control group viewed pre made visualizations instructional intervention eight students group selected semi structured interviews results showed intervention based visualization construction resulted significantly better acquisition sorting concepts however significant difference groups respect students attitudes toward computer programming qualitative data analysis indicated students experimental group constructed necessary abstractions engagement visualization construction activities authors study argue students active engagement visualization construction activities explains one side students success side explained instructional approach constructionism case used design instruction conclusions implications study used researchers instructors dealing computational thinking
upper bound roots given sum largest two terms bound lagrange gained attention different sides recently succinct proof seems missing present short original proof lagrange bound approach leads definite improvements benefit computationally improvements construct modified lagrange bound asymptotic computational complexity per cent optimal degrees elsevier ltd rights reserved
intermittent hypoxia ventilatory intermittence due sleep disorders obstructive sleep apnea lead cardiac arrhythmia coronary artery disease conductance disturbances cardiac failure sub clinical overt hypothyroidism important physiopathological complex linked cardiovascular risk alteration lipidic profile promoting atherogenic mechanisms two pathologies combined exponentially increase cardiovascular event risk case report demonstrates young patient obesity arterial hypertension accusing irregular heart beats despite normal resting ecg echocardiography patient presented malignant ventricular arrhythmias revealed holier ecg epworth scale patient presented numerous episodes hypopnea increased apnea hypopnea index associated ventricular arrhytmias polisomnography endocrine profile patient revealed sublinical hypothyroidism untreated lead accelerated atherosclerosis arrhytmic risk cpap treatment alongside levothyroxine treatment tsh levels mui controlled malignant arrhythmic events without complex antiarrhythmic drugs sustaining pathogenic contributions two pathologies arrhythmogenesis process
full implementation semantic web requires widespread availability fuzzy ontologies paper develop complete approach automated tool formalizing fuzzy object oriented database food models using fuzzy ontologies constructing fuzzy ontologies food models investigate apply constructed fuzzy ontologies reason food models firstly propose complete formal definition food models considers features food models basis propose approach constructing fuzzy ontologies food models approach transform food models including schema object instance information fuzzy ontologies also give full proof correctness construction approach provide full construction example furthermore implement prototype tool called foodfonto automatically construct fuzzy ontologies food models tests demonstrate approach actually works finally constructed fuzzy ontologies used reason food models reasoning rules reasoning example provided
beginning century digital imaging technology replaced traditional silver halide film photography implications contamination lake nahuel huapi popular patagonia tourist destination impacted municipal silver contamination photographic processing facilities since silver concentrations dated sediment core lake bottom showed fold increase background levels second half century decrease trend corresponds well published annual global photography industry demand clearly shows evolution replacement traditional silver halide film photography digital imaging technology significant decreases concentrations sediments mussels fish across lake lower trophic organisms variable whole body concentrations dry weight plankton benthic macroinvertebrates hepatic concentrations crayfish mussels predatory fish significantly elevated relative muscle often concentrations detection limit trophodynamic analyses using delta whole body invertebrate muscle concentrations indicated food web biodilution trends high sedimentation rates conjunction reduction silver waste products discharged lake result change digital image processing technologies resulting unplanned welcome remediation contamination lake nahuel huapi elsevier ltd rights reserved
prenatal development highly plastic readily influenced environment adverse conditions shown alter organ development predispose offspring chronic diseases including diabetes hypertension notably appears changes glucocorticoid hormones glucocorticoid receptor levels peripheral tissues could play role development chronic diseases previously demonstrated vitro fertilization ivf preimplantation embryo culture associated growth alterations glucose intolerance mice however unknown signaling affected adult ivf offspring show expression increased inbred cbl outbred bdf blastocysts following vitro culture elevated levels also present adipose tissue adult male mice importantly genes involved lipolysis triglyceride synthesis responsive also increased adipose tissue indicating increased activates downstream gene pathways promoter region previously reported epigenetically modified perinatal manipulation showed changes dna methylation status findings demonstrate ivf results long term change gene expression sex tissue specific manner changes adipose tissues may well contribute metabolic phenotype mice conceived ivf
solid thermal finite element model suspension bridge main cable established finite element software ansys layered grid divided along radial direction main cable main cable thermal parameters including heat conductivity coefficient specific heat thermal expansion coefficient fitting least square method three dimensional transient temperature field main cable simulatd based thermal parameter fitting results main girder tower suspension made beam element solid thermal model main cable connected suspension bridge degree freedom main cable consistent main girder tower model accurately simulate uneven temperature field main cable fire scenario calculate elastic modulus tensile strength high temperature
rapid urbanization key driver unique set health risks facing urban populations one critical health hazards facing urban women intimate partner violence ipv post conflict urban areas women may face even greater risk ipv yet studies examined ipv experiences urban dwelling conflict affected women including internally displaced study qualitatively examined social structural characteristics urban environment contributed ipv experiences women residing post conflict abidjan cte ivoire ten focus groups conducted men women internally displaced idps non displaced lack support networks changing gender roles tensions traditional gender norms modern city reported key contributors ipv urban poverty unemployment food insecurity housing instability also played role finally idps faced heightened vulnerability ipv result displacement discrimination relationship economic strains ipv similar conflict affected settings abidjan urban environment presented unique characteristics contributing ipv understanding factors crucial designing appropriate services women implementing ipv reduction interventions urban areas strengthening formal informal mechanisms help seeking utilizing multi modal interventions address economic stress challenge inequitable gender norms well tailoring programs specifically idps considerations ipv program planning focused conflict affected women urban areas
background autism spectrum disorder asd sexually dimorphic brain structure genetics behaviors studies brain tissue age population clearly factor interpreting study outcome yet sex rarely considered begin address issue extend previously published microarray analyses examine expression small noncoding rnas sncrnas including micrornas mirnas asd control temporal cortex males females predicted mirna targets identified well pathways overpopulate findings considering age sexual dimorphism asd sncrna expression persists temporal cortex patterning distinguishes regions among sexually dimorphic mirnas mir mir promote oligodendrocyte differentiation mir implicated neuronal differentiation mir implicated anxiety putative mirna targets significantly represented immune nervous system pathways sexes consistent previous mrna studies even common pathways specific target mrnas often sexually dimorphic example male female target genes significantly populate axonal guidance signaling pathway yet less third targets common sexes conclusions findings sexual dimorphism sncrna levels underscore importance considering sex addition age interpreting molecular findings asd brain
conducted year nationwide survey elucidate clinical outcomes patients primary myelofibrosis pmf japan questionnaires sent annually approximately hematology departments newly diagnosed patients pmf enrolled study followed annually collect prognostic information approximately patients enrolled per year yielding total patients pmf included study median age diagnosis years time analysis median survival duration months year overall survival rate infection disease transformation acute leukemia frequent causes death proposed prognostic models predicting outcomes pmf patients japan dynamic international prognostic scoring system pmf plus model feasible forty three patients received allogeneic hematopoietic stem cell transplantation allosct median days diagnosis treatment significantly prolonged survival pmf patients year overall survival rate first allosct long term registration study required evaluation prognosis impact treatments survival
study investigated utility hyperspectral remote sensing data estimating green percent vegetation cover pvc study site canadian high arctic field experiment conducted sabine peninsula degrees degrees melville island nunavut canada collect field spectra pvc five vegetation types polar semi desert dry mesic tundra dmt mesic tundra wet mesic tundra wmt wet sedge moss wsm based field spectra two types band hyperspectral hyperion multi spectral worldview vegetation indices vis derived using possible band combinations optimal spectral bands identified based correlations green pvc addition vis designed landscapes examined ability estimate green pvc arctic environment results indicate pvc spectral features arctic vegetation types related moisture content vegetation types dry intermediate soil moisture dmt possessed large amounts bare soil exhibited spectral properties similar bare soil vegetation types high moisture content wmt wsm exhibited spectra similar senescent vegetation given substantial proportion senescent vegetation vegetation types optimal hyperion spectral bands estimating green pvc located absorption features observed arctic vegetation spectra including leaf pigment absorption along red edge slope leaf water absorption leaf cellulose lignin absorption narrowband vls exhibited stronger correlation green pvc broadband vls due finer spectral features sampled hyperspectral data vis designed estimate leaf pigment dry matter content lignin cellulose showed strong correlations green pvc elsevier inc rights reserved
brief morning exposure bright light improves subjective symptoms performance nurses rapidly rotating shifts katsutoshi tanaka department occupational mental health graduate school medical sciences kitasato university objective investigate whether brief bright light exposure workday mornings improve health performance safety nurses rapidly rotating shifts methods conducted randomized crossover study involving registered nurses teaching hospital working two shift system including night shift participants instructed expose min workday mornings results total participants enrolled present study thirty one participants received exposure first month received second month significant improvements noted periods compared non periods self assessed sleepiness day shift days evaluated using karolinska sleepiness scale self assessment night sleep day shift days using visual analogue scale fatigue assessed using checklist individual strength questionnaire estimated mean difference scale confidence interval respectively mean response time evaluated using psychomotor vigilance task test pvt showed significant improvement periods compared non periods statistically significant differences observed sleepiness depression number pvt lapses frequency perceived adverse events near misses conclusion findings suggest brief exposure mornings preceding day shift effective improving sleepiness performance day shift work subjective nighttime sleep day shift days perceived fatigue preceding two weeks rapidly rotating shift nurses occup health
trabecular bone porous mineralized tissue found vertebral bodies metaphyses epiphyses long bones irregular flat shaped bones pore space filled bone marrow highly cellular fluid together bone marrow behave poroelastic solid poroelasticity theory permeability primary material property governs momentum transfer solid fluid constituents linearized theory permeability material depends shape connectivity pores developing model relationship trabecular microarchitecture permeability could lead improved simulations trabecular bone mechanical response used investigate bone adaptation mechanobiological signaling progression diseases osteoporosis study used finite element models trabecular pore space calculate complete anisotropic permeability tensor human porcine femoral trabecular bone samples sensitivity simulations model assumptions post processing analyzed improve confidence result orthotropic permeability tensor depended fabric tensor trabecular spacing structure model index power law relationship porosity fabric alone also provided reasonable prediction may useful cases image resolution insufficient obtain detailed measures architecture
social jet lag term describing misalignment social biological times article argued currently used formula social jet lag captures misalignment also sleep debt resulting sleep deprivation workdays proposed adopt sleep corrected formula social jet lag takes form difference sleep onset free days workdays case subjects longer sleep later equal sleep onset free days compared workdays takes form difference sleep offset free days workdays subjects longer sleep earlier equal sleep offset workdays compared free days
present paper studies multi mode resource constrained project scheduling problem mrcpsp wherein tasks different execution modes implying duration different resource requirements execution project may encounter problems may cause schedule deterioration even unfeasibility utmost goals firstly proposition set new disruption measures used new objective functions resolution objective problem minimizing project makespan disruption measure latter solved evolutionary algorithm new reactive multi objective heuristic considering project progress paper focuses mainly problem feasibility pareto front performance algorithm cpu time given feasibility problem static mrcpsp complete kolisch drexl transform objective mrcpsp problem multi objective problem including penalty cope potential violation non renewable resource constraints enlarge search space show schedule adjustment necessary problem solving process diverse set non time consuming operators also included algorithm elsevier ltd rights reserved
neuropeptide oxytocin influences prosocial behavior aggression stress responsiveness diverse effects regulated species context specific manner naked mole rat heterocephalus glaber unique species study context dependent effects exhibiting strict social hierarchy behavioral specialization within subordinate caste soldiers aggressive defend colonies unfamiliar conspecifics workers prosocial contribute colony behaviors pup care determine involved subcaste specific behaviors compared behavioral responses workers soldiers sexes modified resident intruder paradigm quantified activation neurons hypothalamic paraventricular nucleus pvn supraoptic nucleus son using immediate early gene marker fos localized neurons resident workers soldiers age matched unfamiliar worker stimulus animals intruders encounters videorecorded scored aggressive behaviors colony matched controls left home colony duration encounters brains extracted cell counts conducted immunoreactive fos percentage fos double labeled cells results indicate resident workers less aggressive showed greater neural activity soldiers furthermore linear model including social treatment cortisol subcaste revealed subcaste significant predictor fos double labeled cells pvn data suggest naked mole rats promotes prosocial behaviors rather aggression even within subordinates status exerts robust effects brain behavior elsevier inc rights reserved
kolkata city water supply dependent surface water sources river hooghly groundwater sources large part kolkata metropolitan area kma currently served groundwater pumped aquifer deep city city draws water aquifers rapidly recharge adjacent town salt lake city covering area conglomerate several salt lakes years back though planned satellite town water level also decreasing fast due overuse groundwater rate year therefore objectives study find reason depletion water level depict present piezometric level kolkata salt lake city identify threat land subsidence arsenic contamination already begun area classify areawise subsidence rate assume future threat methodology followed chapter mainly analysis secondary data related temporal change groundwater level counting land subsidence rate result shows city water level receded especially areas north south kolkata around city area level comes close falls clay layer ideal subsidence areas subsidence ranges year creating high risk zones remedial measures given form groundwater recharge rainwater harvesting mandatory installation rooftop harvesting kolkata salt lake along improvement chemical quality water
malignancy major cause death patients inflammatory disease risk individual malignancies altered inflammatory diseases rheumatoid arthritis psoriasis study aimed examine malignancy incidence patients psoriatic arthritis psa related inflammatory disease institutional cancer registry medical record linkage systems retrospectively reviewed population based incidence cohort patients psa age sex matched comparators malignancy rates compared using adjusted cox models incidence overall malignancy excluding nmsc hazard ratio confidence interval breast cancer nmsc significantly elevated psa cohort age female sex similar predisposing risk factors cohorts overall incidence malignancy well risk breast cancer higher patients psa general population
ball screw drives used automation applications machine tools translate rotational motion electric motor translational motion slide frequency responses show characteristic torsional translational resonances resonance frequencies vary slide position due distributed stiffness inertia flexible ball screw proposed model treats ball screw flexible element using ritz series expansions obtain finite approximation continuous deformations use problem specific basis functions allows low order approximation making model especially well suited control design model shows excellent validation results reproduces variation resonance frequencies high accuracy
examine associations recent intimate partner violence ipv reproductive coercion frequency use reproductive sexual health services cross sectional survey administered year old women seeking care five family planning clinics evaluated associations recent experiences ipv ipv recent care seeking pregnancy testing emergency contraception sexually transmitted infection testing using multinomial logistic regression sixteen percent respondents reported ipv reported past months four percent respondents reported ipv recent without ipv associated increased odds seeking one aor multiple pregnancy tests aor multiple sti tests aor using emergency contraception aor multiple times aor recent ipv without associated increased odds seeking one aor multiple pregnancy tests aor using emergency contraception aor combined effect recent ipv increased odds seeking multiple pregnancy tests aor using emergency contraception multiple times aor seeking sti testing aor multiple times aor frequent requests pregnancy sti testing emergency contraception among young females seeking care may indicator greater risk recent alone combination ipv
objectives convolutional neural networks cnns subtype artificial neural network shown strong performance computer vision tasks including image classification date limited application cnns chest radiographs frequently performed medical imaging study hypothesize cnns learn classify frontal chest radiographs according common findings sufficiently large data set materials methods institution research ethics board approved single center retrospective review adult posterior anterior chest radiographs final reports performed men average age patient type inpatient outpatient emergency department waiver informed consent googlenet cnn trained using graphics processing units automatically classify radiographs normal cardiomegaly consolidation pleural effusion pulmonary edema pneumothorax network performancewas evaluated using receiver operating curve analysis test set radiographs criterion standard board certified radiologist interpretation results using pixel images input network achieved overall sensitivity specificity area curve classifying study normal abnormal categories sensitivity specificity area curve respectively pleural effusion pulmonary edema consolidation cardiomegaly pneumothorax conclusions current deep cnn architectures trained modest sized medical data sets achieve clinically useful performance detecting excluding common pathology chest radiographs
study develops renewable energy management system rems control photovoltaic smart inverters mitigate voltage violation distribution systems high penetration installation impact analysis distribution feeders system integration decision making smart inverter control embedded rems solve voltage violation problem verify effectiveness proposed rems enhance system voltage quality system installed distribution feeder taiwan power company taipower selected field testing real power reactive power voltage studied system collected impact analysis integration performed solve mitigation voltage variation control reactive power compensation smart inverters found voltage test system consistent field test results computer simulation distribution feeder large farm executed illustrate control smart inverters enhance utilization solar energy reducing curtailment renewable power generation dramatically distribution system high penetration systems
episodic recurrent local cutaneous mucosal swelling key features angioedema vasoactive agents histamine bradykinin highly implicated mediators swelling attacks challenging assess contribution bradykinin clinical expression angioedema accurate biomarkers generation vasoactive peptide still lacking review describe mechanisms responsible bradykinin production hereditary angioedema hae central role coagulation factor xii fxii plays evidently several plasma parameters coagulation change attacks hae may prove valuable biomarkers disease activity propose changes secondary vascular leakage rather direct consequence fxii activation furthermore biomarkers fibrinolytic system activation plasminogen activation also change attacks hae changes may reflect triggering bradykinin forming mechanisms plasmin finally multiple lines evidence suggest neutrophil activation mast cell activation functionally linked bradykinin production put forward paradigm fxii functions sensor molecule detect conditions require bradykinin release via crosstalk cell derived enzymes understanding mechanisms drive bradykinin generation may help identify angioedema patients bradykinin mediated disease could benefit targeted treatment
stimulant drugs produce reward also activate stress responsive systems corticotropin releasing factor crf related hypothalamus pituitary adrenal hpa axis stress responsive systems activated stimulant drugs however role stimulant drug induced reward remains poorly understood herein report crf receptor deficient crf wild type mice show conditioned place preference cpp responses relatively low cocaine dose conversely wild type crf mice display cpp responses relatively high cocaine dose indicating crf receptor deficiency alters rewarding effects cocaine acute pharmacological antagonism crf receptor antalarmin also eliminates cocaine reward nevertheless crf mice display higher stereotypy responses cocaine wild type mice despite low plasma corticosterone concentration crf mice show higher nuclear glucocorticoid receptor levels brain region hippocampus wild type mice full rescue wild type like corticosterone circadian rhythm level crf mice exogenous corticosterone affect crf receptor dependent cocaine reward induces stereotypy responses cocaine results indicate critical role crf receptor cocaine reward independently closely related hpa axis activity elsevier ltd rights reserved
past researches showed empathy pain triggers resonance mechanism self also modulated contextual factors using functional magnetic resonance imaging present study demonstrated short term media violence exposure reduced pain ratings also activation anterior insula anterior mid cingulate cortex pain thus violence exposure modulated empathic responses pain based physiological desensitization elsevier inc rights reserved
although cancer patients generally strongly advised quit smoking order improve treatment efficacy survival patients smokers time cancer diagnosis continue smoking psychological factors depression anxiety likely associated smoking behavior following cancer diagnosis empirical evidence scarce observational study aimed estimating smoking cessation rates assessing effect smoking cessation psychological symptoms well predictive role psychological variables smoking cessation smoking relapse following cancer surgery part larger prospective epidemiological study smokers first diagnosis nonmetastatic cancer completed hospital anxiety depression scale insomnia severity index fear cancer recurrence inventory quitters pair matched nonquitters compared symptom pre quitting post quitting month follow predictors smoking cessation smoking relapse including psychological variables also investigated fifty five patients stopped smoking least one occasion study quitters experienced relapse pre quitting quitters significantly higher levels anxiety fear cancer recurrence nonquitters symptoms significantly diminished post quitting months later subgroup patients breast cancer significantly predicted smoking cessation relative risk depressive symptoms significant predictor smoking relapse study highlights importance psychological symptoms predicting tobacco cessation relapse among individuals cancer findings suggest breast cancer patients inclined stop smoking patients cancers future studies attempt delineate effect smoking cessation gender demographics characterize subgroup study also suggests particular attention paid early management depressive symptoms order prevent smoking relapse
clarify roles neutrophils anti neutrophil cytoplasmic autoantibody anca associated vasculitic neuropathy studied neutrophil extracellular traps nets peripheral nerve vasculitis stored nerve samples patients microscopic polyangiitis mpa immunohistochemically analyzed using antibodies citrullinated histone cith various neutrophil enzymes defined merged cith extracellularly released myeloperoxidase mpo net formation also compared net formation mpo anca positive negative mpa rheumatoid arthritis associated vasculitic neuropathy nets identified mostly vasculitic small arterioles mpo anca positive mpa patients frequency higher anca negative patients nets found vasculitic neuropathy patients chronic inflammatory demyelinating polyradiculoneuropathy nets also observed peripheral nervous system mpa patients well lung kidney results suggest nets may involved pathogenesis mpa neuropathy
mexican male female transgender asylum seekers united states suffer serious health issues attributed stressors related transgender ethnic minority socioeconomic status study explored stressors resulting health issues needs particularly vulnerable population asylum seekers sworn declarations psychological evaluations examined multidisciplinary research team using systematic document review process review identified stressors occurred mexico united states verbal physical sexual assaults unstable environments fear safety security hiding undocumented status economic insecurity health issues resulted part stressors include posttraumatic stress disorder depression anxiety sleep issues isolation avoidance drug alcohol use suicidal tendencies despite suffering multiple health issues asylum seekers rarely sought health social services health promotion practitioners play important role serving silent minority expanding community based research focused intersection transgender ethnic minority socioeconomic status using trusted community members connect population necessary resources providing communication training resource development health care providers creating network service organizations understand needs transgender asylum seekers
use power converters considerably grown part refined control strategies recently proposed including nonlinear schemes predictive control approach used work considering variable grid frequency environment order get appropriate response wide mains frequency range indeed order achieve appropriate dynamic static responses operating frequencies number samples per period kept constant independent mains frequency allows fixed resolution sensed voltages currents preferable high performance digital control schemes required however imposing constant number samples per period requires variable sampling time systems feature variable mains frequency hand predictive control developed well documented constant sampling frequency work presents extend predictive control algorithms variable sampling time allowing high performance waveforms wider mains frequency range simulated experimental results show feasibility proposed control strategy corroborates mathematical model analysis
focal small bowel lesions present diagnostic challenge radiologist gastroenterologist detection characterization small bowel masses greatly improved advent multidetector enterography cte cte increasingly utilized workup occult gastrointestinal bleeding article review spectrum focal small bowel masses pathologic correlation adenocarcinoma common primary small bowel malignancy presents focal irregular mass occasionally circumferential extension leading obstruction small bowel carcinoid tumors commonly arise ileum characterized avid enhancement marked desmoplastic response metastatic lesions aneurysmal dilatation small bowel pathognomonic lymphoma secondary findings lymphadenopathy splenomegaly sought benign small bowel masses leiomyoma adenoma may responsible occult gastrointestinal bleeding however primary vascular lesions small bowel remain common cause occult small bowel gastrointestinal bleeding arterial phase contrast obtained cte aids recognition vascular nature lesions systemic conditions peutz jeghers syndrome crohn disease may suggested presence multiple small bowel lesions lastly potential pitfalls ingested material considered faced focal small bowel masses
paper introduces new approach design distributed manufacturing control systems shown multi agent principles self learning self adaptation new engineering method distributed production systems used enhance integration production control process quality control highlighted multi agent systems may implemented enforce interaction manufacturing execution system distributed control system enhancing exploitation available information quality control process control levels additional focus set production process modeling quality control algorithms engineering methodology integrating aspects within final results validated field white ware using washing machine production line
paper new single phase flux reversal machine design increased power weight ratio described technique electromagnetic calculation based solving magnetostatic problems developed construction
many vital interdependent cellular functions including proteostasis lipogenesis homeostasis executed endoplasmic reticulum exogenous insults impair performance must rapidly corrected cell death ensue protective adaptations boost functional capacity form basis unfolded protein response upr activated response accumulation misfolded proteins upr halt protein translation increasing proteinhandling chaperones degradation erroneous proteins conserved three tier molecular cascade however prolonged activation upr result maladaptation system resulting activation inflammatory apoptotic effectors recently upr involvement neurodegenerative disease attracted much interest numerous potentially drugable points crosstalk emerging summarize functions upr highlight evidence potential role pathogenesis alzheimer disease discussing several key targets therapeutic potential wolters kluwer health inc rights reserved
aimed identify key pathways explore molecular mechanism underlying pediatric pneumonia using differential pathway network integrated protein protein interactions ppi data pathway information ppi data pathway information obtained string reactome database respectively next pathway interactions identified basis constructing gene gene interactions randomly weight value computed using spearman correlation coefficient assigned pathway pathway interaction thereby detect differential pathway interactions subsequently construction differential pathway network implemented using cytoscope following network clustering analysis using clusterone finally topological analysis differential pathway network performed identify hub pathway top degree distribution significantly pathways identified construct pathway interactions discarding pathway interactions weight value differential pathway network constructed contained interactions pathways topological analysis showed hub pathways fgfr fusion mutants molecules associated elastic fibres fgfr mutant receptor activation identified significantly signaling fgfr fusion mutants fgfr mutant receptor activation simultaneously appeared two clusters molecules associated elastic fibres existed one cluster accordingly differential pathway network method might serve predictive tool help understand development pediatric pneumonia fgfr fusion mutants fgfr mutant receptor activation molecules associated elastic fibres might play important roles progression pediatric pneumonia elsevier ltd rights reserved
uncertainty must taken account aspects ambient intelligence human decisions activities investigate utilize probabilistic possibilistic sources information use humanized decision making particular examine aspects possibilistic conditioning probability developed yager provide bounding resulting probability analysis cases completely certain uncertain probability possibility distribution carried additionally cases intermediate uncertainty general case possibilities analyzed zadeh consistency measure also used assess cases consider whether conditioned probability informative decision making three measures shannon entropy gini index renyi entropy used compare original probability distributions conditioned distribution cases described
additive manufacturing technologies enable fabrication parts characterized shape complexity therefore allow design optimized components based minimal material usage weight literature two approaches available reach goal adoption lattice structures topology optimization recent work computer aided method generative design optimization regular lattice structures proposed method investigated configurations cantilever beam considering six different cell types two load conditions order strengthen method paper number test cases carried results explain behavior method iterations effects load cell dimension moreover visual comparison proposed method results achieved topology optimization shown
holographic algorithms alternatively known pfaffian circuits received much attention giving polynomial time algorithms subset problems much work done determining power machinery one intriguing aspect circuits must planar investigate relaxations planarity condition show approach using orbit closures work give different technique allows one swap gate used pfaffian circuit given suitable bases restricted types graphs done exploiting fact pfaffian gates lie hyperplane elsevier inc rights reserved
green building fund gbf established part clean business australia initiative aimed mitigating risk climate change forming close partnerships government business industry specifically targeted reduce impact built environment australia greenhouse gas ghg emissions reducing energy consumption operation commercial office buildings part selection process projects assessed three merit criteria potential reduction ghg emissions demonstration potential quality project design management alternative framework proposed contributes rigour current selection process particular contends use second order moment markov chain establish present worth feasibility green investment underlying parameters interest discount rate cash flows terms savings uncertain framework useful ausindustry funding body gbf government departments worldwide responsible awarding green building funds also owners keen strengthening application improving demonstration project feasibility
cancer initiation presumed occur utero many childhood cancers hypothesized advanced paternal age may impact due increasing number mutations sperm dna increasing paternal age examined association paternal age specific types childhood cancer offspring large nationwide cohort children born denmark children identified danish medical birth registry linked information national registers including danish cancer registry total children diagnosed cancer age years adjusted hazard ratio childhood cancer according paternal age estimated using cox proportional hazards regressions found confidence interval higher hazard rate every years advantage paternal age acute lymphoblastic leukemia clear association found acute myeloid leukemia hazard ratio years confidence interval estimates neoplasms central nervous system suggested lower hazard rate higher paternal age hazard ratio years confidence interval clear associations found remaining childhood cancer types findings suggest paternal age moderately associated higher rate childhood acute lymphoblastic leukemia acute myeloid leukemia offspring firm conclusions could made specific cancer types new older fathers impart mutations children leading frequent childhood cancer investigate authors looked data cohort children born denmark years found higher rate acute lymphoblastic leukemia acute myeloid leukemia among children born fathers age years conversely children older fathers seemed experience fewer central nervous system neoplasms childhood cancers showed clear link father age
microstructure morphology tio tio tio tio composite powders prepared smart mini ball miller characterized xrd sem edax ftir dsc xrd results showed composite powders mainly amorphous anatase phase high crystallinity sem study composite powders reveals average particle size ftir peaks observed around represent bending vibrations groups composite powders dsc analysis weight gain tio composite powders weight loss tio composite powders finally microstructure characterizations composite powders ball milling investigated propose optimal route obtaining composite powders suitable thermal spray process elsevier rights reserved
potential electric power generation marine tidal currents enormous tidal currents recognized resource exploited sustainable generation electrical power high load factors resulting fluid properties predictable resource characteristics make marine currents particularly attractive power generation advantageous compared renewable energies moreover international treaties related climate control triggered resurgence development renewable ocean energy technology therefore several demonstration projects tidal power scheduled capture tidal generated coastal currents regarding emerging promising area research paper reviews marine tidal power fundamental concepts main projects around world also report issues regarding electrical generator topologies associated tidal turbines moreover attempts made highlight future issues index emerging technologies mainly according relevant works carried wind turbines ship propellers
aim aim study examine sports injury pattern establish cost injuries relation training competitive badminton players malaysian national sports school methods one year prospective observational study recruited year old students obtaining informed consent appointed guardian participants requested report injuries pain disabilities occur within study period september august either training competition injured students seek treatment researcher made weekly visits followed accordingly return full training details progress injuries documented visit results sixty three injuries recorded soft tissue sprains strains commonest injury one third injuries occurred lower limb especially knees followed back injuries injuries require training modification half injuries resumed training within one week upon full training half still symptomatic injury risk injury rate injuries player training hours conclusion badminton injuries mostly involved lower limb almost overuse injuries occurred lower limb however badminton injuries whole predominantly sprains strains overuse nature widely believed
evidence links high levels autism spectrum disorder traits women chronicity anorexia nervosa study reports clinical audit impact asd traits treatment outcomes girls referred treatment specialist eating disorder service presence current early childhood asd traits elevated comparison previously reported community samples current asd traits correlated emotional disorders need treatment augmentation psychiatric inpatient day patient admission relationship significant contribution depression controlled difference morgan russell outcomes discharge high low current asd traits parent reported asd related developmental difficulties associated attenuated change self reported cognitive symptoms study highlights need understanding aetiology diagnostic significance predictive utility future relapse elevated asd traits childhood eating disorders copyright john wiley sons ltd eating disorders association
aim study improve thermal conductivity thermal stability mechanical properties bisphenol dicyanate ester addition nanodiamond cyanate ester nanodiamond composites containing various ratios nanodiamond prepared thermal stability thermal conductivity samples evaluated thermogravimetric analysis differential scanning calorimetry laser flash method respectively samples characterized analysis gel content water absorption capacity stress strain test hydrophobicity samples determined contact angle measurements moreover surface morphology samples investigated scanning electron microscopy obtained results prove cyanate ester nanodiamond composites good thermal mechanical properties used many applications electronic devices materials engineering emergent copyright john wiley sons ltd
aim evaluate role tumor infiltrating lymphocytes til predicting molecular response preoperative endocrine cytotoxic treatment patients achieve pathological complete response stromal str til centrally evaluated samples diagnostic core biopsies patients included two prospective randomized trials letlob trial neoadjuvant endocrine based treatment giob trial neoadjuvant chemotherapy based treatment pre post treatment centrally assessed strtil evaluable cases letlob trial giob trial median strtil patients high strtil strtil aeyen frequently breast cancer ductal histology high grade high neoadjuvant endocrine treatment letlob cohort significant suppression pre post treatment observed low high strtil groups high strtil patients achieve frequently relative suppression aeyen baseline compared low strtil patients non significant neoadjuvant chemotherapy giob cohort significant suppression observed low strtil patients wilcoxon high strtil group cohort rate patients achieving relative suppression aeyen baseline significantly higher high low strtil group geometric mean suppression evaluated cohort according strtil lowest value observed high strtil cases treated chemotherapy hypothesis generating study suggests breast cancer strtil baseline may influence achievement molecular response neoadjuvant treatment evaluation large studies needed interaction type treatment warrants explored
present paper operational amplifier amp topology achieves high gain low power dissipation designed analyzed design uses current mirror class output stage capacitive miller compensation low power operational amplifier main active power consuming block proposed amp operates supply voltage consumes total power gain proposed design implemented using tanner eda tools cmos technology node
compared results brief video based multiple stimulus without replacement preference assessment access chosen activities mswo results assessment access mswo four children autism also compared instructor rankings activities mswo results strong moderate correlations mswo mswo assessment results found across participants correlation mswo instructor rankings ranged strong low across participants implications directions future research discussed
age increasing digital data transmission network data security measures become important crucial issue two main security schemes used protect sensitive data cryptography steganography good imperceptibility appropriate data capacity two important properties characterize steganography technique paper hybrid technique proposed utilizing steganography cryptography hide sensitive patient data pixel values medical colored image medical colored image chosen cover image lossless compression png format sensitive data patient data examination data firstly encrypted using block encryption method embedded image make harder recognize interpret attacked embedding algorithm pixels medical cover image chosen randomly based values produced using primitive root numbers two least significant bits blue alpha channels used hide encrypted patient sensitive medical data experimental results shows quality stego image relatively less distortive highly imperceptible human eye good data hiding capacity assure security
fenoxaprop ethyl fpe studied possible ecotoxicity two representative toxigenic cyanobacteria including microcystis aeruginosa microcystis viridis growth curves chlorophyll content protein content microcystin levels oxidative stress apoptosis rates measured two cyanobacteria exposure different concentrations fpe results showed changes chlorophyll content protein content consistent cell density viridis sensitive aeruginosa fpe results oxidative stress indicated fpe induced generation malondialdehyde mda enhanced activities antioxidant enzymes including superoxide dismutase sod peroxidase pod catalase cat two cyanobacteria explore toxicity fpe apoptosis rates toxin levels measured two cyanobacteria different degrees apoptosis rates observed two cyanobacteria apoptosis rates increased increase concentration fpe intracellular extracellular affect fpe presence fpe aquatic ecosystem may stimulate synthesis release may cause serious water pollution pose threats human health results may useful ecotoxicity assessment fpe guiding rational use pesticides agriculture
drospirenone drsp antialdosterone agent progestogenic antiandrogenic effects compound recently used combination beta estradiol hormonal therapy postmenopausal women shown exert significant antihypertensive effect hypertensive post menopausal women aim present study compare effect drsp tibolone endothelial function arterial stiffness lipid profile early postmenopausal women naive post menopausal hormonal therapy twenty four women met inclusion criteria entered study women randomized receive either drsp months blood pressure heart rate similar groups baseline end study compared baseline endothelial function assessed reactive hyperemia significantly improved women receiving drsp whereas significant differences baseline follow detected women receiving tibolone women receiving drsp showed significant decrease pulse wave velocity augmentation index compared baseline changes observed women receiving tibolone capacity sera trigger endothelial cells apoptosis vitro measured cell death assay significantly reduced drsp hfa hfd conclusion present study shows association estradiol drospirenone hormonal replacement therapy significantly improves vascular parameters composition sera relevant vascular protection early postmenopausal normotensive women effects shared tibolone elsevier ireland ltd rights reserved
objectivea parental diagnosis borderline personality disorder associated high levels parenting distress greater risk psychopathology psychosocial issues among children aim present study investigate experience parents diagnosis borderline personality disorder perceptions regarding access appropriate parenting supports resources methodseleven mothers one father past present diagnosis borderline personality disorder participated focus groups asked questions experiences parenting service provision participants aged years standard deviation majority identified caucasian study design qualitative thematic analysis utilised identify common themes resultsthematic analysis identified four key themes parenting challenges parenting rewards barriers accessing support recommendations improving parenting experience seventeen subthemes also identified represented graphically conclusionsparents diagnosis borderline personality disorder find parenting challenging rewarding experience number themes identified parents diagnosis borderline personality disorder similar reported parents forms severe mental illness rewards stigma fear custody loss negative service provision experiences also evidence specific themes relating symptoms borderline personality disorder parenting recommendations provided improving services parents
article based upon research explored eleven twelve year olds understood explained men violence women research found young people examined motivations individual male perpetrators though context heterosexuality young people adulthood appeared generate rigid framework heterosexuality gender differences begin exemplify inequality upon justifications based young people justifications collated themes heteronormativity endorsement marriage restrictive gender roles blaming women violence violence justified inequality questioned endorsed taken granted part adult heterosexual relationship implications young people existing anticipated relationships
knowing faulty modules prior testing makes testing effective helps obtain reliable software develop framework automatic extraction human understandable fuzzy rules software fault detection classification integrated framework simultaneously identify useful determinants attributes faults fuzzy rules using attributes beginning training system assumes every attribute feature useless feature uses concept feature attenuating gate select useful features learning process opens gates closes tightly based utility features system discard derogatory indifferent attributes select useful ones also exploit subtle nonlinear interaction attributes order demonstrate effectiveness framework used several publicly available software fault data sets compared performance method existing methods results using tenfold cross validation setup show system find useful fuzzy rules fault prediction
industry corner introduction current green building practice largely advanced integrated design process integrated design process involves multiple disciplines architecture civil mechanical electrical engineering design method heavily relies utilizing building performance simulation illustrate design parameters affect energy consumption quality indoor environment actual design decisions made anderson architectural design tools integrated design process supersede traditional geometrical exploration instruments sketchup revit archicad rhino negendahl building performance simulating tools ecotect computational fluid dynamics cfd radiance energyplus developed help architects measure building performance natural ventilation daylighting solar radiation energy uses design process attain green building standards leadership energy environmental design leed information presented tools guide architects certain level achieving green building goals however building simulation generally beyond architect knowledge domain many architects difficulty understanding technical terms models well design implications therefore specific consultants emerged help architects grasp meanings numbers models require architects implement high level design collaboration coordination aksamija gou lau simulation consultants work parallel architects early design stage intervene conceptual schematic design may also work behind architects verify building performance design finished make design green technical alterations existing literature argues early intervention building performance simulation architectural design process explores different algorithms models optimal intervention degens scholzen odenbreit sick schade mourtada grausam svetlana olbina yvan beliveau however difference early intervention late verification often investigated qualitative studies help understand building performance simulation actually implemented influences quality design solutions addition quantity performance outcomes current research presents two case studies compare building performance simulation early intervention late verification tool architectural design process contextualizes building simulation research real building practices
research shown personality accurately perceived zero acquaintance although work focused physical appearance growing number studies suggested personality may perceptible sources information current meta analysis examined studies reported accuracy consensus effects perception big five traits text based media online social network websites found substantial consensus five traits moreover extraversion openness experience agreeableness conscientiousness perceived accurately importantly provide aggregate effect sizes researchers might expect examining similar phenomena help guide future studies discuss several potential avenues valuable additional research personality person perception elsevier inc rights reserved
programing difficult beginners need learn new language computers developing software especially complex software bound result problems frustration need think new ways identifying learning behavior behind programing way empirical studies help beginners learn easily study flipped classroom combined blended learning mode adopted switching class instructional time class edx lecture time research laboratory developed system collected teacher students discussion activities adopting problem solving strategies online discussion participants third year college students computer science course university northern taiwan experiment march may total initial comments collected along responding comments comments coded according problem solving steps posing questions offering solutions discussion sharing conclusions inter rater reliability two coders reached kappa value results indicated flipped classroom combined problem solving strategy effective previous problem solving behavior sequence
study pursues line inquiry contemporary gender stereotypes drawn print advertisements cyprus investigation implicit modes stereotyping suggested goffman across explicit gender roles yield novel interesting insights broaden existing knowledge male female advertising depictions content analysis characters study reveals existence gender cliches cypriot magazine advertisements neither male female evolving roles adequately reflected advertisements men tend portrayed traditional masculine stereotypes women lean towards decorative portrayals implicit stereotyping likely suggest subordination lower status women compared men study indicates advertising cyprus reinforces diffusion hostile sexism underrepresentation professional women commonplace portrayal body revealing attires time high proportion women implicit subordination signifies benevolent sexism distorted representation genders raises key public policy concerns diminishing portrayals hold sway upon men women psychological well professional development
polycythemia vera characterized erythropoiesis jak activating mutations increased risks morbidity mortality patients iron deficient treatment often includes hematocrit control phlebotomy may exacerbate iron deficiency associated complications phase response trial evaluated jak jak inhibitor ruxolitinib versus best available therapy bat patients hydroxyurea resistant intolerant ruxolitinib superior bat hematocrit control reduction splenomegaly blood count normalization exploratory analysis first evaluate iron status prospective study patients investigated ruxolitinib effects serum iron markers iron deficiency related patient reported outcomes pro among patients evidence baseline iron deficiency ruxolitinib associated normalization iron marker levels compared lesser improvement bat iron levels remained stable ruxolitinib patients normal iron levels baseline regardless baseline iron status treatment ruxolitinib associated improvements concentration problems cognitive function dizziness fatigue headaches inactivity although improvements generally greater among patients baseline iron deficiency improvements iron deficiency markers pros observed ruxolitinib suggestive clinical benefits warrant exploration authors published elsevier ltd rights reserved
spatial scale animals change movements relation environment central several topics ecology conservation including foraging ecology habitat selection dispersal method first passage time analysis fpt recently proposed measure changes movements landscape index search effort pertinent spatial scales method seems largely applicable increasing number studies using satellite radio tracking global positioning system gps limits yet assessed used several movement simulations examine ability fpt analysis detect area restricted search ars according different changes movements different patch structures tracking accuracy fpt analysis able detect changes movements speed sinuosity changed animal reacted patch boundaries also able detect ars within path several spatial scales patches nested different sizes tracking accuracy affected detection ars fpt analysis widely used argos system minimum locations effective ars necessary detect behaviour seven velocity filtering applied similarly spatial error location affected estimation ars scale value application velocity filtering reduced effect comparisons real gps track pathways simulating argos error showed time sampling rate locations due satellite pass frequency decreased probability detecting ars small scales across whole range scales velocity filter enabled significant reductions effect synthesis application within limits fpt analysis highly suitable animal movement analysis either quantify habitat use determine scale relevant describing ecological system factors affecting movement decisions anticipation increasing applications fpt analysis applied ecology provide recommendations use technique several tracking methods
paper present model transformation language based logic programming language called ptl prolog based transformation language considered hybrid language atl atlas transformation language style rules combined logic rules defining transformations atl style rules used define mappings source models target models logic rules used helpers implementation ptl based encoding atl style rules prolog rules thus ptl makes use prolog transformation engine provided declarative semantics ptl proved semantics equivalent encoded program studied encoding ocl object constraint language prolog goals order map atl ptl thus subset ptl considered equivalent subset atl proposed language also used model validation checking constraints models transformations equipped language debugging tracing capabilities help developers detect programming errors ptl rules additionally developed eclipse plugin editing ptl programs well debugging tracing validation finally evaluated language several transformation examples well tested performance large models elsevier inc rights reserved
bell famous author men mathematics described mathematics queen arts servant science meant mathematics serves science entering picture soon proper mathematical model set scientist purely mathematical analysis model final mathematical step interpreted scientifically purpose present article convince readers sometimes roles science mathematics reversed mathematical problem interpreted physics problem laws physics utilized physical analysis final result physical analysis interpreted mathematically shall illustrate means examples
information communication technology ict applied increasingly supporting human immunodeficiency virus hiv prevention treatment technological advances extended field hiv self management objectives paper examine design use icts hiv self management programs identify knowledge gaps existing practice provide recommendations future research program development systematic review conducted search english literature published prior august six electronic databases inclusion criteria also included either quantitative qualitative assessments hiv self management programs utilized least one ict platform program protocol search identified six studies conducted australia united states studies diverse sample site enrollment criteria study population major functionalities ict platforms mobile phones websites included delivering information modules sending medication reminders supporting self monitoring medical adherence risk behavior reduction enhancing communication among participants providing easy access hiv self management information major challenges faced self management programs utilizing icts lack interaction concern privacy hiv self management programs employed ict platforms limited number geographic coverage programs also tested initial stage small size samples minimum technical innovation lack explicit guiding theories models information behavior technology use observed studies use icts hiv self management interventions emerging field future research would benefit paying attention technical innovation interactive features applying ict platform self management programs icts platforms increasing innovation connecting people places serve powerful tool reduce disparities health care health promotion future research also needed explore feasibility applying ict platforms self management programs serving populations diverse socioeconomic background resource poor settings elsevier ltd rights reserved
natural circulation primary coolant plays important role removing decay heat station black sbo accident reactor core decay heat removal systems rvacs phxs cooling lead based reactor order study natural circulation characteristics primary coolant reactor vessel air cooling system rvacs primary heat exchangers phxs cooling crucial safety lead based reactors three dimensional cfd model china lead based research reactor clear built analyze thermal hydraulics characteristics primary coolant system cooling capability two systems abilities two cooling systems different decay heat powers discussed well results demonstrated decay heat could removed effectively relying either two systems however rvacs appeared obvious thermal stratification phenomenon cold pool besides increase decay heat power natural circulation capacity primary coolant two systems significant difference phxs cooling system stronger rvacs respect mass flow primary coolant average temperature difference cold pool hot pool elsevier ltd rights reserved
parenting chinese culture central topic debate whether western derived parenting style applicable chinese cultures terms behavioral profiles relationships child adolescent adjustment study identified subtypes chinese maternal parenting style examined stability changes transition early adolescence urban chinese sample girls four waves longitudinal data collected adolescents fifth years sixth seventh eighth grades latent profile analysis identified four subtypes parenting style authoritative authoritarian average level undifferentiated strict affectionate adolescents authoritative mothers exhibited best overall adjustment adolescents authoritarian mothers showed worst adjustment adolescents strict affectionate mothers generally adjusted well authoritative mothers except showed lower academic achievement strict affectionate parenting represented culture specific subtype parenting style chinese culture latent transition analysis revealed high stability parenting styles early adolescence transitions subtypes also evident findings highlight importance revisiting chinese parenting examining developmental course parenting style
want carry effectively distributed method process large power data large data electricity first classified big industries small industries finally put use clustering distinguish electro sort customers paper employed computational framework named spark based memory computing conduct distributed computing adopted supporting vector machine spark lastly results analyzed ensuring final effect test solution speed greatly improved
vagally mediated heart rate variability vmhrv reduced borderline personality disorder bpd non suicidal self injury nssi associated comorbid psychopathology particular bpd aimed examine differences cardiac function vmhrv heart rate comparing adolescents years engaging nssi healthy controls aimed determine clinical concomitants cardiac function patients nssi analyses showed significant group differences cardiac function controlling host confounding variables resting state vmhrv adolescents nssi significantly correlated bpd symptoms current level functioning
bipolar disorder currently treated community academic settings associated surprisingly high degree morbidity treatment resistance poor outcome may due inherent difficulties illness much difficulty appears attributable less optimal pharmacotherapeutic approaches patient education illness emphasize conceptualization illness progressing untoward direction driven several types sensitization mechanisms involving epigenetic changes epigenetics refers environmentally induced chemical changes dna histones micro rna structure function endure long lasting fashion potential accumulating epigenetic marks recurrent stressors episodes bouts substance abuse speaks importance early consistent long term pharmacoprophylaxis starting first episode mania order prevent illness progression review emerging evidence new recommendation ultraintensive treatment first manic episode wealth data indicating importance lithium involved treatment regimen problems bipolar illness morbidity treatment resistance particularly pronounced united states usa compared many european countries bipolar illness usa appears earlier age onset run difficult course psychiatric medical comorbidities greater complexity illness typically requires monotherapy often recommended complex combination therapy multiple medications targeting multiple symptoms pathways instituted judiciously use medications lead better efficacy also contrary convention wisdom fewer side effects hoped reconceptualization bipolar illness progressive one undergo malignant transformation adequately treated help lead revisions conventional treatment practices render illness benign long term outcome
paper present generalized prismatic hybrid meshing method viscous flow simulations one major difficulty implementing robust prismatic hybrid meshing tool handle boundary layer mesh collisions normally extra data structure quadtree two dimensional octree three dimensional required proposed method overcomes difficulty via heuristic approach relies constrained delaunay triangulation tetrahedralization cdt extra data structures required geometrical reasoning used approximate maximum marching distance point walking cdt combined post processing marching vectors distance prohibition multilevel differences form automatic robust mechanism remove boundary layer mesh collisions benefiting matureness cdt techniques proposed method robust efficient simple implement capability demonstrated generating quality prismatic hybrid meshes industrial models complex geometries proposed method believed able considerably reduce effort implement robust hybrid prismatic mesh generator viscous flow simulations authors international journal numerical methods engineering published john wiley sons ltd
development interactive learning content requires special skills like programming techniques web integration graphic design etc generally online educators possess skills learning products tend static like presentation slides textbooks paper propose new interactive model generative learning objects compromise static dull materials dynamic complex software learning materials developed specialized teams find random numbers based automatic initialization learning objects increases content diversity interactivity thus enabling learners engagement resulted learning object model limited level complexity related special learning software intuitive capable increasing learners interactivity engagement motivation dynamic content approach applied successfully several computer programming disciplines
although studies often find racial disparities policing outcomes less known suspect race biases police interactions unfold study examines differentially occurring police suspect interactions white black latino suspects across time hypothesized racial bias may evident earlier interactions less information situation available one hundred thirty nine white black latino use force case files associated written narratives medium large size urban police department united states analyzed trained coders broke interaction narratives discrete sequences dyadic action reaction steps involving suspect action level resistance officer response level force linear mixed effects model run amount police use force suspect race time suspect resistance suspect actions toward third party self controls results demonstrated black latino suspects receive force beginning stages interaction whereas whites escalated level force faster initial levels breaking police suspect interactions discrete sequences current study reveals better understanding bias originates police use force informs focus policing interventions
evolution equation among one important nonlinear partial differential equations exact solutions great interest researchers around globe article new analytical technique used search exact solutions nonlinear evolution equation aid symbolic computation check validity method developed choose srlw equation many new general exact solutions obtained equation great importance efficiency developed scheme confirmed since provides exact solutions techniques used day
registrations multi angle point cloud involve enormous point cloud data complicated heavy computation previous non parallel method strong computing resources demanding low performance point cloud global registration bulk synchronous parallel computing model bsp processes data parallel computing method applied huge computation point cloud data processing design point cloud global registration algorithm base bsp model build hama parallel computing cluster average pcs results four engineering examples show registration algorithm base bsp model reduces computing resources requirements accomplishes global registration acceptable accuracy improves efficiency registration hama computing cluster built implementation simplicity ease point cloud processing improvement thought implementation method extend point clouds processing like filters rendering modeling
concepts developed ian hacking lectures collsge france provided important contribution debates within field philosophy psychiatry professor chair philosophy history scientific concepts michel foucault hacking author reflection classification mental disorders arises problem natural kinds order explain case studies developed hacking paris lectures first back definition series concepts discuss status scientific metaphors finally analyze relationship notions respectively transient mental illness culture bound syndrome emphasize latter derives canadian transcultural psychiatry
developing organism exposed toxicant response ranges none severe death malformation response given dosage may termed teratogenic developmental toxic severity dependent exposure conditions prenatal embryo fetal developmental efd toxicity studies rodents rabbits consistent definitive assessments teratogenic severity teratogenesis screening assays best validated results formula presented estimates teratogenic severity group including control within efd study developmental components include embryonic fetal death malformations variations mean fetal weight contribution maternal toxicity included multiplication factors adjust extent mortality maternal body weight change parameters deemed important derivation formula calculate teratogenic severity described various efd data sets literature presented highlight considerations calculation various components formula score compared concurrent control group obtain relative teratogenic severity limited studies presented suggest relative scores two fivefold higher control detectable low level teratogenic severity scores fivefold higher control increasingly severe teratogenicity scores may help refine concept exposure based validation list use proponents screening assays daston etal estimating severity positive exposures situations defining severity loael lowest observed adverse effect level wiley periodicals inc
examined impact daily supplementation vitamin deficiency function falls female long term care residents initial vitamin deficiency associated greater functional decline increased fall risk despite guideline recommended supplementation highlighting importance preventing vitamin deficiency frail elderly institute medicine iom guidelines recommend vitamin daily older adults maintaining serum hydroxyvitamin optimal skeletal health adequacy iom guidelines sustaining function reducing falls frail elderly unknown female long term care residents aged enrolled osteoporosis clinical trial included analysis participants classified based baseline levels deficient deficient women provided initial vitamin repletion weekly weeks supplemented vitamin daily months annual functional assessments included activities daily living adls instrumental adl iadl physical performance test ppt gait speed cognition spmsq mental health phq used linear mixed models analysis functional measures logistic regression falls daily supplementation maintained levels participants groups demonstrated functional decline women initially deficient greater decline physical function iadl ppt months iadl adl larger increase cognitive deficits months fallers compared sufficient baseline despite supplementation sufficient levels iom guidelines may adequate frail elderly study optimal levels maintaining function preventing falls needed
background aldehyde dehydrogenases aldhs play major role detoxification aldehydes high expression aldhs marker stem cells many organs including lungs common polymorphism aldh gene aldh results inactivation enzyme associated alcohol flushing syndrome increased risk cardiovascular alzheimer diseases cancers effect aldh polymorphism lung stem cells thoroughly examined methods examined association aldh allele lung function parameters population healthy individuals also examined association incidence asthma copd patient cohorts used vitro colony forming assay detect effect polymorphism lung epithelial stem cells primary human surgical samples aldh transgenic aldh mice response acute chronic lung injuries compared wild type aldh aldh mice results humans aldh allele associated lower fev fvc general population development asthma copd bronchial lung epithelium carrying aldh allele showed tendency lower colony forming efficiency cfe compared aldh allele mice tracheal epithelial thickness nuclear density number basal stem cells significantly lower aldh aldh adult mice electron microscopy showed significantly increased number morphologically abnormal mitochondria trachea aldh mice aldh tracheal lung cells showed higher ros levels fewer functional mitochondria mice significant differences detected tracheal lung epithelial stem cells examined vitro cfe exposed chronic cigarette smoke aldh mice resistant emphysema development whereas influenza infection caused epithelial damage aldh mice mice conclusions aldh polymorphism several subtle effects lungs similar changes observed normal aging suggesting premature lung aging effect
rainwater harvesting rwh practiced ethiopia since ancient times shown little development inefficient techniques efforts capture rainwater show significant results owing poor design implementation resulted slow technical development paper details design improvements tested demonstration site well analysis operational parameters similar rainwater quality improvement techniques applied system also discussed various scenarios studied relating design operating parameters replicability decision making construction stage common components existing rwh systems ethiopia discussed contrasted implemented demonstration rwh system moreover particle separation theory techniques introduced quality improvement techniques results analysis also suggest possibility satisfying building demand utilizing installed system also shows potential rwh ethiopia alternative water source
background suicide violence often occur general population well mentally ill individuals studies however assessed whether suicidal behaviors predictive violence risk mental illness aims aim study investigate whether suicidal behaviors including suicidal ideation threats attempts significantly associated increased violence risk individuals schizophrenia method data analyses obtained clinical antipsychotic trials intervention effectiveness catie trial randomized controlled trial antipsychotic medication adults schizophrenia univariate cox regression analyses used calculate hazard ratios hrs suicidal ideation threats attempts multivariate analyses conducted adjust common confounding factors including age alcohol drug misuse major depression antisocial personality disorder depression hostility positive symptom poor impulse control scores tests discrimination calibration reclassification assessed incremental predictive validity suicidal behaviors prediction violence risk results suicidal threats attempts significantly associated violence males females schizophrenia little change following adjustment common confounders suicidal threats however associated significant increase incremental validity beyond age diagnosis comorbid substance use disorder recent violent behavior conclusions suicidal threats independently associated violence risk males females schizophrenia may improve violence risk prediction authors published elsevier open access article license http creativecommons org licenses
neurofeedback training performed consisting rewarding encouraging brainwaves smr simultaneously discouraging brainwaves theta brainwaves high beta right dorsal posterior quadrant brain half hour nfb sessions determine impact cortisol levels dhea levels scores symptom checklist scl quality life inventory acute attack medication usage hereditary angioedema patient
advanced theories exist literature describe extremely complex load carrying mechanisms real bone material necessarily models rely constitutive equations involving numerous parameters determined extensive expensive experiments aim present paper however show simple one dimensional model render first insights possible mechanical behavior bone loss mass loss connectivity considered strength materials type theory based constitutive equations lot parameters well known identification problems simple one dimensional model proposed describe loss mass loss connectivity bone material based thermodynamic considerations involving material forces evolution equations associated internal variables derived parameters model adapted experimental observations obtained sheep glucocorticoid treatment qualitative agreement results proposed model theoretical approaches well experimental results appears quite satisfactory wiley vch verlag gmbh kgaa weinheim
rural african american cocaine users experience high rates stis hiv nida funded trial tested adapted evidence based risk reduction program versus active control condition participants african american cocaine users rural arkansas recruited outcomes included condom use skills self efficacy sexual negotiation skills peer norms self reported risk behavior intervention group experienced greater increases condom use skills overall effectiveness sexual negotiation skills groups reported reductions trading sex improvements condom use self efficacy increased use specific negotiation skills implications limitations discussed
qualitative study assessed experiences assertive community treatment act team members regarding integration physical mental health self management persons serious mental illness three focus groups elicited information participants concerning barriers strategies recommendations findings inductive analyses revealed six overarching themes collaboration primary care improvements engagement team focused roles education training recommendations system level barriers systems collaboration participant recommendations suggest act teams well positioned integrate mental physical health treatment research needed support integrated care
reconfigurability understood ability system behave differently different modes operation commute along lifetime cross cutting concern modern software engineering paper introduces specification method reconfigurable software based global transition structure capture system reconfiguration space local specification operation mode whatever logic equational first order partial fuzzy probabilistic etc found expressive enough handling requirements method two levels made explicit juxtaposed formally interrelated key achieve goal systematic process hybridisation logics relationship local global levels specification becomes internalised logic elsevier rights reserved
studies focused family issues allowed great understanding aspects related subsystems parenting desire expectations couples satisfaction quality child outcomes aspects greatly interconnected contribute creation specific family dynamics quality family interactions present study focuses intuitive parental behaviors quality couple relationship observed decision process intention desire become parents first goal explore aspects cross national sample made italian belgian heterosexual lesbian gay couples aimed evaluate degree internalized homophobia affects parental alliance quality couple relationship parental behaviors evaluated recruitment group stable heterosexual gay lesbian couples individuals years age without children wanted become parents used prenatal lausanne trilogue play evaluate parental alliance couple satisfaction assessed dyadic adjustment scale internalized homophobia miss line existent literature analysis find difference lesbian gay heterosexual couples terms parental alliance high levels couple adjustment lead better parental performances among italian belgian couples results suggest also sexual stigma differs one country another impact capability managing parenting clinical implications verified longitudinal studies order observe impact inter generational transmission psychopathology
background recent studies shown early antiretroviral therapy art initiation results significant hiv transmission reduction rationale behind test treat policy world health organization implementation policy lead increased incidence art related adverse effects especially sub saharan africa ssa region yet ready cope challenging issue main body introduction widespread use art drastically changed natural history hiv aids exposure art leads serious medication related adverse effects mainly explained mitochondrial toxicities situation get worse near future indeed art associated increased risk developing cardiovascular disease lipodystrophy prediabetes overt diabetes insulin resistance hyperlactatemia lactic acidosis prevalence disorders already high ssa situation exacerbated implementation new recommendations ssa countries characterized extreme poverty weak health systems inadequate low quality health services inaccessibility existing health facilities lack qualified health personnel lack adequate equipment inaccessibility unaffordability medicines heavy workload context double burden disease additionally dearth data incidence predictive factors art related adverse effects ssa anticipate strategies put place prevent occurrence conditions properly estimate upcoming burden prepare adequate response plan required anticipate effectively prevent upcoming burden conclusion ssa would first region experience huge benefits implementing test treat policy region yet prepared manage consequential increased burden art related toxic metabolic complications urgent measures taken fill lacunae ssa become burdened consequences test treat policy
present study applies social learning differential association theory explanation political violence focusing exposure extremist content new social media nsm controlling key variables derived rival theories data gathered using paper pencil study among high school students web survey targeting youths years old total respondents form dataset binary logistic regression used analyze data results show even controlling background variables strain variables personality characteristics moral values peer influences statistical association measures extremism nsm ensm self reported political violence remains significant fairly constant persistent effects found measures individuals actively seek extremist content internet opposed passive accidental encounters using nsm furthermore offline differential associations racist delinquent peers also strongly directly related self reported political violence mechanisms rival perspectives indicates political violence partially explained social learning suggests impact ensm mediated real world associations offline world taken account
inflammatory prostaglandin pge favors cancer progression epithelial tumors characterized persistent oncogene input however effects tumor cell sternness poorly understood molecular level describe two epithelial tumor cells originating human lung skin tumors epithelial growth factor egf induces sequential regulation mpges inos enzymes producing inflammatory intracellular milieu demonstrated concerted action egf mpges inos causes sharp changes cell phenotype demonstrated acquisition stem cell features activation epithelial mesenchymal transition emt primed egf epithelial tumor cells transfected mpges inos ensure steady enzyme levels display major stem like emt markers reduction cadherin concomitant rise vimentin aldh aldh activity tumorsphere studies cells show increased sphere number size enhanced migratory clonogenic capacity sharp changes emt markers indicating activation process concerted action enzymes forms well orchestrated cascade expression inos depends overexpression mpges indeed show downstream effectors pge pica pik akt mpges recruits non canonical transcription factors thus facilitating inos production conclusion propose initial event leading tumor stem cell activation may leveraged intrinsic mechanism players either inherent constituents egf highly inducible proteins mpges inos tumor cells suggest incipient tumor aggressiveness may moderated reducing pivotal input mpges elsevier inc rights reserved
significant clinical need engineered bone graft substitutes quickly effectively safely repair large segmental bone defects one emerging field interest involves growth engineered bone tissue vitro within bioreactors promising perfusion bioreactors using bioreactor systems tissue engineered bone constructs fabricated vitro however engineered constructs lack inherent vasculature implanted quickly develop necrotic core nutrient exchange occurs utilized comsol modeling predict oxygen diffusion gradients throughout aggregated alginate constructs allowed computer aided design printable vascular networks compatible large tissue engineered construct cultured perfusion bioreactor investigated effect printed macroscale vascular networks various porosities viability human mesenchymal stem cells vitro using gas permeable non gas permeable bioreactor growth chamber walls use printed vascular structures conjunction tubular perfusion system bioreactor cell viability found increase much core constructs silico modeling predicting construct viability steady state
literature developmental trajectory cognition autism spectrum disorders asd presents several inconsistent findings review focus information processing specifically use gist verbatim representations guide memory reasoning concept formation added perspective fuzzy trace theory may help resolve mixed results regarding frequency nature effectiveness gist processing asd providing established process models tasks suitable use individuals levels functioning order demonstrate utility fit field asd research present evidence three complementary theories weak central coherence wcc executive function theory mind tom dominated landscape date discuss potential utility fit tasks process models proposing testable hypotheses address ambiguous conflicting results current literature applying theory typical development study asd may add value past future research elsevier inc rights reserved
background avian antigen common cause hypersensitivity pneumonitis inhalation challenge pigeon serum pigeon dropping extract pde elicits hypersensitivity reaction patients bird related hypersensitivity pneumonitis brhp antigenic components materials yet fully elucidated method pigeon serum pigeon intestine homogenates pde immunoblotted serum samples patients brhp patients summer type patients humidifier lung healthy volunteers among protein spots found pigeon serum pde reacted sera brhp patients identified mass spectrometry immunoassays using recombinant protein performed confirm antigenicity identified protein cytokine production peripheral blood mononuclear cells pbmcs stimulated recombinant protein also assessed results immunoglobulin lambda like polypeptide igll identified spots immunoblots pigeon serum pde brhp patients exhibited higher levels serum igg antibody recombinant igll rigll compared control subjects well stronger pbmcs proliferative response rigll cytokine production pbmcs brhp patients rigll exposure indicated protein could induce prone immune responses increase tnf alpha absence elevated production conclusions pigeon igll identified brhp antigen present pigeon serum pde
motor neuron extrinsic mechanisms shown participate pathogenesis als sod one familial form amyotrophic lateral sclerosis als remains unclear whether mechanisms contribute familial forms tdp fus associated als characterize single copy mouse model als fus conditionally expresses disease relevant truncating fus mutant endogenous murine fus gene show mice mice heterozygous fus null allele develop similar pathology als fus patients mild motor neuron phenotype importantly cre mediated rescue fus mutation within motor neurons prevented degeneration motor neuron cell bodies delayed appearance motor symptoms indeed observed downregulation multiple myelin related genes increased numbers oligodendrocytes spinal cord supporting contribution behavioral deficits show mutant fus triggers toxic events motor neurons neighboring cells elicit motor neuron disease
paper presents implementation automated roll roll fluidic self assembly system based surface tension driven self assembly applications field macroelectronics reported system incorporates automated agitation web motion component dispensing recycling process enables assembly electrical connection semiconductor dieschips continuous parallel fashion wide area substrates present method achieves assembly rate chips per hour assembly yield exceeding testing assembly standard square shaped dies size scaling system desired throughput possible due parallel manner self assembly identification modeling relationship process parameters forces studied experimentally verified testing effect web angle agitation assembly detachment rates application demonstrate realization solid state lighting module particular application requires assembly conductive multilayer sandwich structure achieved combining introduced assembly process novel lamination step
allergen specific immunotherapy ait currently recognized clinically effective treatment allergic diseases unique disease modifying effect ait introduced clinical practice one century ago performed early years allergenic extracts poor quality definition mechanism allergic reaction recognized practice ait refined leading remarkable improvement efficacy safety profile treatment currently ait accepted routinely prescribed worldwide respiratory allergies hymenoptera venom allergy subcutaneous scit sublingual slit routes administration used pediatric population ait recommended allergic rhinitis conjunctivitis without allergic asthma evidence specific ige sensitization towards clinically relevant inhalant allergens long term studies provided evidence ait also prevent onset asthma new sensitizations favorable response ait strictly linked adherence treatment lasts years therefore several factors carefully evaluated starting intervention including severity symptoms pharmacotherapy requirements children caregivers preference compliance recent years increasing interest role ait treatment ige associated food allergy extrinsic atopic dermatitis growing body evidence shows oral immunotherapy represents promising treatment option ige associated food allergy contrary still controversies effectiveness ait patients atopic dermatitis consensus document promoted italian society pediatric allergy immunology siaip provide evidence based recommendations ait order implement optimize current prescription practices treatment allergic children
background psychosocial distress common among cancer patients significant associations coping social support distress quality life adult cancer patients identified little known interrelationships distress medical coping social support adolescents young adults ayas objective aims study investigate prevalence psychological distress chinese ayas cancer examine associations among distress anxiety depression medical coping social support population methods total aya patients recruited study patients completed chinese version national comprehensive cancer network distress thermometer hospital anxiety depression scale medical coping modes questionnaire social support rating scale results prevalence psychological distress chinese ayas cancer scores highest year old patients scores positively correlated anxiety depression negatively correlated medical coping social support conclusion prevalence psychological distress aya cancer patients higher general cancer population medical coping social support lower prevalence psychological distress aya cancer patients implications practice findings suggest need evidence based intervention strategies enhance medical coping social support aya cancer patients nurses crucial implementing psychological interventions aya cancer patients
circadian clock biological system allows organisms adapt temporal constraints environment governs body functions circadian clock endogenous period entrains external day means timing cues also called zeitgebers discrepancy internal external day internal day certain body functions results circadian desynchrony prominently represented jet lag circadian desynchrony may factor many diseases review presents literature impact circadian desynchrony disease development special focus critical illness addressed treatment options far investigated also presented
cigarette smoking poses significant health burdens people mental illness die sooner smoking major contributor high rates morbid chronic physical health conditions early mortality compared general population family carers provide important support people mental illness however family carers perspectives smoking family members mental illness largely absent research literature practice despite smoking rates remaining high quit rates remaining low population know little family carers could involved supporting people mental illness smoke stop smoking paper aims provide discussion opportunities family carers support family member smoking cessation discussion preliminary research topic available literature appears family carers well placed support smoking cessation population however struggled physically philosophically emotionally perceived responsibilities involving family member smoking caring role felt isolated asserted limited support service providers assist concluded family carers important agents within person immediate environment could help improve smoking cessation success suggests also mental health services health service providers could benefit including family carers efforts support smoking cessation people mental illness smoke
humanoid robots complex kinematic chains whose modeling error prone robot model well calibrated hand pose determined precisely encoder readings affects reaching grasping accuracy work propose novel method simultaneously estimate pose robot hand calibrate robot kinematic model achieved combining stereo vision proprioception computer graphics model robot notably use gpu programming allows perform estimation calibration real time execution arm reaching movements proprioceptive information exploited generate hypotheses visual appearance hand camera images using computer graphics model robot includes kinematic texture information hypotheses compared actual visual input using particle filtering obtain best estimate hand pose set joint offsets calibrate kinematics robot model evaluate two different approaches estimate pose hand vision silhouette segmentation edges extraction show experimentally pose estimation error considerably reduced respect nominal robot model moreover gpu implementation ensures performance times faster cpu one allowing real time operation
fetal neonatal hyperthyroidism may occur mothers graves disease fetal thyrotoxicosis manifestation observed transition tsh receptor stimulating antibodies fetus weeks pregnancy fetal tsh receptors becoming responsive weeks diagnosis confirmed fetal tachycardia goiter bone age advancement pregnancy maternal treatment conducted accordance probability neonatal hyperthyroidism high babies mothers ongoing antithyroid requirement higher antibody levels last months pregnancy clinical manifestation may delayed days antithyroid drugs taken mother neonatal hyperthyroidism symptoms confused sepsis congenital viral infections herein diagnosis therapeutic approach reviewed cases fetal neonatal hyperthyroidism
dna molecule building block living organism recently detection specific dna target potential field organism species authentication also disease diagnostics gene therapy dna molecule unique attribute molecular recognition two dimensional graphene oxide material provides excellent physio chemical properties utilization detection specific dna molecule hence bring forward structure dna biomolecule described graphene synthesis methods molecular binding pattern dna different detection techniques along potential application use nanomaterial finally outlined conclusion future perspectives area
great number people suffer burning injuries around world year applying appropriate wound dressing promote new tissue formation prevent losing water inhibit invasion infectious organisms study egg white long standing history homemade remedy fabricated wound dressing burn injuries reason ovalbumin films cross linked ethyl dimethyl aminopropyl carbodiimide hydrochloride edc different concentrations using three concentrations ethanol physical chemical characterizations including fourier transform infrared spectroscopy ftir gas transmission rate gtr tensile mechanical tests water uptake degradation rate performed samples sample crosslinking agent ethanol considered optimized one kpa ultimate tensile strength elongation break water uptake addition biological evaluations conducted mtt live dead assay indicated sign cyto toxicity samples moreover scanning electron microscopy sem showed fibroblast cells well spread sample formation filopodia conclusion modified ovalbumin applied base material fabrication wound dressing skin care products elsevier rights reserved
study explores method generating electricity recovering waste heat integration heat pipes thermoelectric generators hpteg system simultaneous waste heat recovery power generation processes achieved without use moving parts hpteg system consists bismuth telluride thermoelectric generators teg sandwiched two finned pipes achieve temperature gradient across teg electricity generation counter flow heat exchanger built using two separate air ducts air ducts thermally coupled using hpteg modules evaporator section heat pipe absorbed waste heat hot air duct heat transferred across teg surfaces condenser section hpteg collected excess heat teg cold side releasing cold air duct electrical heater installed hot air duct simulate exhaust gas air blower installed inlet duct direct flow air ducts theoretical model developed predicting performance hpteg system using effectiveness number transfer units method developed model able predict thermal electrical output hpteg along rate heat transfer results showed increasing cold air velocity effectiveness heat exchanger able increased approximately consequence improved heat transfer maximum power output obtained
avian origin influenza virus cause concern china spring infections resulted acute respiratory distress syndrome ards severe form acute lung injury ali contributes morbidity mortality study induced viral ali infecting wild type ccl deficient mice influenza vir results suggested close association betwe motif chemokine ligand ccl expressions ali induced lethal virus strain hebei elevate ccl levels also detected confirmed human cases bronchoalveolar lavage fluid balf infected mice moreover ccl overexpressed lung tissue infected mice importantly ccl deficiency ameliorated induced ali mice determined weight loss survival rate wet dry ratio lung pathology taken together findings demonstrate ccl essential virus infection thus potential therapeutic target influenza
present vmm wta structure general purpose low power compact programmable classifier architecture demonstrate equivalence layer perceptron classifier generates event outputs suitable integration event driven systems present measured data simple linear non linear classifier structures chip demonstrate implementation xor function using layer vmm wta classifier
various carbonate leaching studies performed upon abu zeniema uranium slurry concentrates uranium moisture content optimize dissolution process study kinetics thermodynamics process complete dissolution performed using sodium carbonate min stirring time degrees solid aqueous ratio carbonate leaching experimental data well interpreted shrinking core model diffusion control porous product layer order reaction found pseudo first order apparent activation energy mole
annual average rainfall coastal area bangladesh rainwater harvesting rwh practiced long time drinking water supply household rwh capacity storage tanks varies litres model type storage tanks provided several rwh programs government ngos optimum storage tank volume investigated considering family size demand roof types rainfall result households avail water rainwater tanks six months rest year depend unreliable distance sources aim developing comprehensive decision support tool reliable rwh system design curves storage volume developed three climatic conditions dry average wet years available roof catchment area rainfall loss factor household demand lpcd typical six members family using mass curve moreover spreadsheet based daily water balance model developed assess reliability currently used water tanks analysis showed currently used tanks insufficient meet year long drinking cooking water demand average dry climatic conditions achievable reliability significantly varies increase catchment area tank size maximum achievable reliability large quantity water lost spilled water even tank size water used purposes larger tanks used capture excessive spilled water
site construction osc regarded effective means improving construction quality efficiency adoption osc slower developing countries china developed countries research barriers inhibiting sector growth inadequate paper aims investigate major factors inhibiting adoption osc reference chinese construction market thirty factors influencing use osc identified literature review questionnaire survey face face interview professionals construction industry questionnaire sent developers china completed questionnaires retrieved ranking analysis used identify critical factors top three barriers absence government regulations incentives high initial cost dependence traditional construction methods factor analysis enables grouping critical factors five categories namely government regulations policies technological innovation industry supply chain cost market demand paper also indicates dominant five groupings pertains regulations policies findings provide valuable reference developers understand major barriers decision making government bodies aiming promoting osc construction industry put forward relevant policies incentives
models cognitive processing anxiety disorders state socially anxious children display several distorted cognitive processes maintain anxiety present study investigated role social threat thoughts social skills perception relation childhood trait state social anxiety total children varying levels social anxiety performed short speech task front camera filled self reports trait social anxiety state anxiety social skills perception social threat thoughts results showed social threat thoughts mediated relationship trait social anxiety state anxiety speech task even controlling baseline state anxiety furthermore found children higher trait anxiety social threat thoughts lower perception social skills display social skills deficit results provide evidence applicability cognitive social anxiety model children
purpose review cardiovascular mortality remains high due insufficient progress made managing cardiovascular risk factors diabetes mellitus physical inactivity smoking healthy lifestyle choices play important role management modifiable risk factors mobile health mhealth defined use mobile computing communication technologies mobile phones wearable sensors delivery health services health related information review examine recent studies utilized mhealth tools improve management risk factors examples developing countries available recent findings mhealth intervention used depends availability resources developing countries often restricted text messages resourceful settings shifting towards mobile phone applications wearable technology diabetes mellitus extensively studied different settings results encouraging tools utilized increase physical activity expensive studies limited resource abundant areas shown mixed results smoking cessation promising initial results use technology mhealth ability recruit participants beyond actively seeking quit established summary mhealth interventions appear potential tool improving control cardiovascular risk factors rely individuals making healthy lifestyle choices data related clinical impact commercially available tools lacking studies needed assess interventions target multiple cardiovascular risk factors impact hard cardiovascular outcomes
new edge directed interpolation nedi algorithm non iterative orientation adaptive achieves better edge performance enhancing remote sensing images natural images conventional linear cubic methods also theoretical foundation many complex regression auto regression interpolation methods although nedi impressive performance computation complexity obstacle large scale expansion parallel acceleration nedi provides strong versatility extensibility paper propose fine grained implementation nedi using gpu fine grained approach assign calculations one unknown pixel threads using nvidia tesla gpu case asynchronous transfer gpu optimization efforts using fine grained nedi achieve speedup fold considering transfer time compared original single threaded cpu code compiling optimization intel core demonstrate effectiveness fine grained scheme also compare fine coarse grained schemes interpolating video adopting fine grained scheme achieve real time display fine grained parallel mode expanded algorithms based regression auto regression schemes elsevier inc rights reserved
objective aimed review approaches urologist gynecologist management overactive bladder oab material methods questionnaire consisting items answered urologist gynecologist differences frequency encountering oab viewpoints concerning conservative treatment experience related anticholinergic drug use management refractory oab compared results majority urologists gynecologists responded question often encounter oab patients daily practice patients respectively common complaint consulted urologists gynecologists urge incontinence frequency using questionnaire voiding diary similar specialties observed urologists gynecologists recommended conservative treatment first line treatment overactive bladder low sociocultural level important obstacle confronting application conservative treatment methods survey participants indicated important factor affected decision select anticholinergic agent first line treatment overactive bladder higher effectiveness drugs urologists gynecologists patients started receive anticholinergic drugs frequently complained urologists gynecologists dry mouth based responses urologists gynecologists frequent reason anticholinergic drug withdrawal patients inability tolerate side effects drugs participants indicated case unsatisfactory response one anticholinergic agent swithching rate another anticholinergic drug among urologists among gynecologists addition urologists gynecologists recommended another pharmaceutical form drug higher dose patients similar number physicians indicated prescribed anticholinergic drug continued least months case unresponsiveness patient could considered refractory majority urologists gynecologists chose perform urodynamic tests patients unresponsive anticholinergic treatment conclusion attitudes urologist gynecologist diagnosis treatment oab mostly correlating current guideline practices exceptions urologists tend use bladder diaries questionnaires less frequently whereas gynecologists refer urodynamic studies patients refractory oab less urologists however irrespective clinical speciality conservative treatment modalities rarely administered
physical attractiveness suggested indicator biological quality therefore stable however transient factors gaze direction facial expression affect facial attractiveness suggesting compared relative importance variation faces variation within faces due facial expressions participants viewed photographs men women displaying six basic facial expressions anger disgust fear happiness sadness surprise neutral expression rater saw model randomly chosen expression effect expressions attractiveness similar male female faces although several expressions significantly different identity times important emotion attractiveness male female pictures suggesting attractiveness stable since hard tissues face unchangeable people may still able perceive facial structure whatever expression face displaying still make attractiveness judgements based structural cues
currently tourism moving towards sustainable tourism industry poses negative impacts environment tourism industry consumes produces many resources water energy waste purpose research determine rate participation green approaches malaysia green hospitality industry methodology used depth interviews observations research finding shows operators adopt greener approaches three common areas energy waste water less participation indoor air quality sustainable management site renewable energy rainwater harvesting system authors published elsevier ltd
changes global climate drivers multiple impacts lake ecosystems rain wind conditions control catchment surface runoff lake mixing regimes however human activities lakes watersheds may direct indirect impacts aquatic optical properties therefore identifying key drivers controlled human climate represents important objective present study develop algorithm estimate concentrations suspended particulate matter spm lake hongze fourth largest freshwater lake china using modis aqua images concurrent data collected six cruise surveys algorithm resulted root mean square errors rmses spm ranging algorithm applied cloud free modis aqua images results show inter annual seasonal variations spm concentrations lake hongze divided two distinct periods transition associated intensive dredging activities initiated spm concentrations exhibit four typical patterns spatial distribution depend local meteorological wind speed wind direction hydrological conditions catchment rainfall huai river flowrate based results new spatial zoning lake derived support government agency monitoring study shows additive synergistic effects climate change human activities spm concentrations short long timescales possibility monitor changes remote sensing shallow optically complex lakes elsevier inc rights reserved
increasing performance wider spread use automated semantic annotation entity linking platforms empowered possibility using semantic information information retrieval keyword based information retrieval techniques shown impressive performance addition semantic information increase retrieval performance allowing accurate sense disambiguation intent determination instance identification name researchers already delved possibility integrating semantic information practical search engines using combination techniques using graph databases hybrid indices adapted inverted indices among others one challenges efficient design search engine capable considering semantic information would need able index information beyond traditional information stored inverted indices including entity mentions type relationships objective work paper investigate various ways different data structure types adopted integrate three types information including keywords entities types systematically compare performance different data structures scenarios data structure types adopted three types information different data structure types integrated storing retrieving three different information types report findings terms performance various query processing tasks boolean ranked intersection different indices discuss index type would appropriate different conditions semantic search elsevier ltd rights reserved
objectives gain deeper comprehension current vulvovaginal atrophy vva knowledge among spanish postmenopausal women methods online survey revive conducted four european countries overall sample participants included spain perceptions experiences needs spanish postmenopausal women terms sexual vaginal health reported results vaginal dryness common vva symptom spain severity symptoms reported postmenopausal women tended similar worse onset especially troublesome symptom dyspareunia vva symptoms significantly impact spanish participants ability achieve sexual enjoyment relationship partner sexual spontaneity although participants partners sexually active sex drive reduced one third consequence vva despite fact women expected doctors start asking menopausal symptoms rarely occurred treatments administered mainly vaginally without prescription using counter products time postmenopausal women discussed symptoms physicians twice likely treated low compliance treatment justified spanish participants bothersome enough symptoms relief inability reverse vaginal changes treatment price almost half participants current local estrogen prescription showed satisfaction acknowledged main limitation treatments inability restore natural conditions vagina price counter products also reported important concern spanish postmenopausal women conclusion vva remains underdiagnosed undertreated spain despite high frequency significant impact quality life since patient satisfaction available treatments remains compromised effective discussion symptoms therapies doctors would improve management
health visitors need competences promote healthy early parent infant relationships aims study explore whether differences groups health visitors without additional parenting program education terms knowledge infant parent interaction observation assessment skills interactions cross sectional study included health visitors certified marte meo therapists health visitors without additional parenting program education health visitors observation skills measured assessing five video recorded mother infant interactions questionnaire used measure intention self efficacy knowledge certified marte meo therapists health visitors without additional parenting program education reported significantly higher mean level knowledge early relationship versus certified marte meo therapists health visitors without additional parenting program education reported higher mean level knowledge infant self regulation versus latter group reported significantly higher need education versus compared health visitors without parenting program education health visitors certified marte meo therapists reported significantly higher frequency correct assessment mothers sensitivity two five video recordings compared video compared video respectively results present study support use video based education health visitors increase knowledge skills assessing parent infant interactions randomized controlled trials needed determine whether improved level health visitors knowledge observation skills may assigned participation marte meo education program
study electrochemically activated persulfate proposed degrade organic contaminants using oxcarbazepine oxc model compound results showed higher removal rates oxc compared persulfate alone electrocoagulation alone ferrous activated persulfate process kinetic model regarding reactive species developed model fitted experimental data well second order rate constants oxc reacting hydroxyl sulfate radical calculated respectively based relative rate technique substantially contributed oxc degradation whereas contribution higher current density increased removal rates oxc increased low current densities decreased high current densities particular degradation oxc significantly enhanced increasing persulfate dosages affected speciation iron solution turn led poorly removal rate alkaline conditions whereas natural organic matter nom dramatically inhibited degradation oxc consuming radicals addition efficient removal rates para chlorobenzoic acid antipyrine carbamazepine tetracycline similar reaction conditions also confirmed results show promising ability system control water pollution caused organic contaminants elsevier rights reserved
negative health effects water pollution remain major source morbidity mortality china chinese government making great efforts strengthen water environment treatment however studies evaluated effects water treatment human health water pollution china study evaluated association water pollution health outcomes determined extent environmental regulations water pollution may lead health benefits data extracted china health retirement longitudinal study charls random effects model random effects logit model applied study relationship health water pollution mediator model used estimate effects environmental water treatment health outcomes intensity water pollution unsurprisingly water pollution negatively associated health outcomes common pollutants industrial wastewater differential impacts health outcomes effects stronger low income respondents water environment treatment led improved health outcomes among chinese people reduced water pollution mediated associations water environment treatment health outcomes results study offer compelling evidence support treatment water pollution china elsevier ltd rights reserved
need accurate knowledge complex dynamical behavior high performance mechatronic systems led development vast amount nonparametric system identification approaches recent years aim paper compare several proposed methods based experiments physical complex mechanical system bridge gap identification theory practical applications industry basic identification approaches often norm typical practical implications operation closed loop control multivariable coupled behavior nonlinear effects included analysis finally possible approach fast reliable identification illustrated based measurement results interventional medical ray system published elsevier ltd
consider problems computing maximal minimal non empty suffixes substrings longer text length minimal suffix problem show every tau tau logn exists linear space data structure tau query time logn tau preprocessing time sample application show data structure used compute lyndon decomposition substring text tau time number distinct factors decomposition maximal suffix problem give linear space structure query time preprocessing time words simultaneously achieve optimal query time optimal construction time elsevier rights reserved
experiments atomic scale simulations suggest transmission plasticity carriers deforming amorphous crystalline nanolaminates mediated biphase interface amorphous crystalline layers paper present micromechanics model biphase nanolaminates describes defect interactions amorphous crystalline interface aci model based effective temperature framework achieve unified description slow configurational atomic rearrangements phases driven equilibrium show second law thermodynamics constrains density defects rate configurational rearrangements apply framework dislocations crystalline solids shear transformation zones stzs amorphous materials effective temperature formulation enables interpret observed movement dislocations aci production stzs interface diffusion configurational disorder across material demonstrate favorable agreement experimental findings reported kim adv funct mater demonstrate aci acts sink dislocations source stzs
importance fault diagnoses kind machinery stated undetected small fault machinery probably rise time cause machinery shut thus resulting mechanical importantly economical loss industry recent years researches done faults diagnosis analysis vibration sound signatures extraction characteristic signatures complicated process complexities modern day machineries results many vibration sound generating sources paper presents condition based fault diagnoses technique detect condition gear experimental setup consisting worm gear driven electric motor setup conduct tests different working conditions vibration sound signature signals worm gear examined normal faulty conditions different speeds oil levels collected data used feature extraction using fast fourier transform filter background noise signals collect signature gearbox vibration sound signals mlp multilayer perceptron artificial neural network model developed classify signature signals thermal camera also used observe heating patterns working conditions help mlp artificial neural network possible predict speed oil level gearbox hence possible fault diagnoses also feasible elsevier ltd rights reserved
renewable energy system order ensure continuous production batteries associated charge controller always necessary whenever source charging solar wind hydraulics photovoltaic systems excessive energy produced solar cells intense sunlight peak conditions could damage batteries charge controller therefore used maintain suitable charging voltage batteries input voltage module rises charge controller regulates process thus preventing overcharging paper presents practical solution grid systems using standard commercial elements detailed analysis carried based experimental results battery charge control allowing long life high safety autonomous storage production systems experimental work performed solar battery charged module maximum power point tracking three stage charging cycle mppt tscc charge controller benefits three stage charging cycle tscc control well maximum power point tracking mppt thus proven efficiency recharge qualitatively quantitatively hydrogen energy publications llc published elsevier ltd rights reserved
transformational leadership trending style competency embraced many industries nursing practice settings similar positive influence follower engagement teamwork solidarity might experienced transformational leadership employed administration faculty guiding framework nursing education impact embedding teamwork culture basic nursing education could significant students ultimately nursing profession research needed develop test application transformational leadership framework nursing education
challenge precise positioning nanopositioning using smart materials hysteresis limiting positioning accuracy preisach model based delayed relay operator hysteresis modelling introduced model identified experimental data input function ensuring information input levels paper presents implementational issues respect hysteresis compensation using preisach model showing procedure follow avoiding pitfalls identification inversion issues due discrete nature preisach model discussed specific linear interpolation method tested experimentally showing effective avoidance excitation vibrational dynamics smart material experimental results hysteresis compensation presented showing approximate error reference measured displacement consequences insufficient discretization level high frequency reference signal illustrated showing significant deterioration hysteresis compensation performance
plant transpiration main evaporative flux terrestrial ecosystems controls land surface energy balance determines catchment hydrological responses influences regional global climate transpiration regulation plants key still completely understood process underlies vegetation drought responses land evaporative fluxes global change scenarios thermometric methods sap flow measurement widely used quantify whole plant stand transpiration forests shrublands orchards around world large body research applied sap flow methods analyse seasonal diurnal patterns transpiration quantify responses hydroclimatic variability syntheses sap flow data regional global scales extremely rare present sapfluxnet initiative aimed building first global database plant level sap flow measurements preliminary metadata survey launched december showed encouraging response sap flow community sap flow data sets field studies representing species globally distributed sites main goal sapfluxnet analyse ecological factors driving plant stand level transpiration sapfluxnet open promising research avenues unprecedented global scope namely exploring spatio temporal variability plant transpiration relationship plant stand attributes summarizing physiological regulation transpiration means water use traits usable land surface models iii improving understanding coordination gas exchange plant level traits hydraulics analysing ecological factors controlling stand transpiration evapotranspiration partitioning finally sapfluxnet provide benchmark test models physiological controls transpiration contributing improve accuracy individual water stress responses key element obtain robust predictions vegetation responses climate change
background choma district southern zambia neonatal mortality rate approximately per live births although rate decreasing many deliveries take place outside formal facilities understanding local practices postnatal period essential optimizing newborn care programs methods conducted depth interviews five focus groups eight observational sessions recently delivered women traditional birth attendants clinic hospital staff three sites focusing skin thermal cord care practices newborns home results newborns generally kept warm application hats layers clothing thermal protection provided preterm small newborns practice nighttime bathing cold water common vernix considered important preterm newborn dangerous hiv exposed infants mothers applied various substances skin umbilical cord special practices preterm infants applied substances included petroleum jelly commercial baby lotion cooking oil breastmilk common substances applied umbilical cord powders made roots burnt gourds ash ward malevolent spirits similar powders reportedly placed directly dermal incisions especially ill children conclusions thermal care newborns commonly practiced exists harmful practices locally appropriate behavior change interventions aim promote chlorhexidine place commonly reported application harmful substances skin umbilical cord reduce bathing newborns night address immediate bathing hiv infected newborns
objective paper evaluate potential tank based rainwater harvesting systems free standing houses source control method mitigate peak roof runoff due rainfall urban areas aim water balance simulation rainwater tank carried using high resolution rainfall series toilet water demand data extracted database results built previous field campaign involving six experimental households southern italy simulations show significant potential runoff peak reduction exists basically depending rainwater tank size characteristics water demand house
objective aim study determine sociodemographic parameters hormonal profile infertile man patients methods included study patients presenting infertility dating back least two years abnormal semen analysis patients came radio immunological laboratory assays determination fsh prl testosterone assessment infertility results age patients ranged years years average age years employees represented frequency consulted primary infertility followed traders primary infertility hormonal assessment abnormal cases rise fsh observed patients elevated patients prl patients low testosterone among endocrinopathies suspected hypogonadism hypergonadotrophic represented frequency testicular deficiencies found cases hypogonadism hypogonadotrophic cases hyperprolactinemia isolated cases obstructive causes cases conclusion many endocrinopathies induce male infertility congenital acquired concern several stages hypothalamus pituitary testis important diagnose thoses endocrinopathies accessible treatment pan africau urological surgeons association production hosting elsevier rights reserved
detail design implementation initial evaluation virtual reality education entertainment edutainment application called virtual environment interactions venvi venvi application students learn computer science concepts process choreographing movement virtual character using fun intuitive interface exploratory study participants part summer camp geared towards promoting participation women science engineering programmatically crafted dance performance virtual human subset students participated immersive embodied interaction metaphor venvi creating metaphor provides first person embodied experiences using self avatars seek facilitate engagement excitement interest computational thinking qualitatively quantitatively evaluated extent activities summer camp programming dance moves embodied interaction within venvi facilitated students edutainment presence interest excitement engagement computing potential alter perceptions computing computer scientists results indicate students enjoyed experience successfully engaged virtual character immersive embodied interaction thus exhibiting high telepresence social presence students also showed increased interest excitement regarding computing field end summer camp experience using venvi
chemerin adipokine regulates adipogenesis metabolic functions mature adipocytes mainly activation chemokine like receptor cmklr elevated levels chemerin found individuals obesity type diabetes osteoporosis adipokine identified inflammatory metabolic syndrome marker considering association metabolic syndrome bone health remains unclear present study aimed clarify role chemerin pathophysiology bone loss induced dyslipidemia particularly modulating osteoclastogenesis vitro analyses showed downregulation cmklr early stage differentiation gradual increase late stages strikingly chemerin modify osteoclast differentiation markers osteoclast formation however increased actin ring formation bone resorption activity mature osteoclasts increased bone resorption activity induced chemerin effectively inhibited cmklr antagonist ccx chemerin boosting mature osteoclast activity involves erk phosphorylation moreover two models dyslipidemia high fat diet hfd treated mice exhibited significantly increased level chemerin serum gingival tissue morphometric analysis showed hfd treated mice exhibited increased alveolar bone loss compared respective control mice associated regulation chemerin cmklr cathepsin mrna expression gingival tissue treatment mice ccx effectively inhibited bone loss antagonism chemerin receptor also inhibited expression cathepsin gingival tissue results show chemerin increases osteoclasts activity vitro also increased level chemerin dyslipidemic mice plays critical role bone homeostasis american society bone mineral research
help new design tools manufacturing integrated solutions generated concurrently consider function process based design pattern matrix solution elements developed realize product function systematically utilizing manufacturing induced properties developed manufacturing integrated product solutions refined using computer aided methods feature based modeling information modeling product embodiment generated specifically tailored chosen manufacturing technology integrated information model allows introduced tools used throughout entire development process example linear flow split snap fit fastening illustrates tools beneficially interact realize manufacturing potential resulting innovative product design
background development tobacco use treatments effective smokers critical improving clinical public health multiphase optimization strategy uses highly efficient factorial experiments evaluate multiple intervention components possible inclusion optimized tobacco use treatment factorial experiments permit analyses influence patient characteristics main interaction effects multiple relatively discrete intervention components study examined whether person factor smoking characteristics moderated main interactive effects intervention components week self reported abstinence rates methods fractional factorial experiment evaluated six smoking cessation intervention components among primary care patients prequit nicotine patch none prequit nicotine gum none preparation counseling none intensive cessation person counseling minimal intensive cessation telephone counseling minimal weeks combination nicotine replacement therapy nrt nicotine patch nicotine gum results psychiatric history smoking heaviness moderated intervention component effects comparison participants self reported history psychiatric disorder positive history showed better response weeks combination nrt poorer response counseling interventions also contrast light smokers heavier smokers showed poorer response counseling interventions conclusions heavy smokers psychiatric histories demonstrated differential response intervention components research illustrates use factorial designs examine interactions person characteristics relatively discrete intervention components future research needed replicate findings elsevier ireland ltd rights reserved
according rapid spread internet new devices web applications using newest multimedia technologies proposed one another become commodity instant new web communications natural intelligible interaction corresponding user various demands required communication persons direct dialogue interaction web also real world widely known psychology field nonverbal information hard express words expression face gesture playing important role research new analysis method interaction using dynamical model proposed paid attention characteristic gestures especially gestures special motions lively powerful actions used effectively kabuki anime dance special gestures speech presentation attracting audiences analyzing mechanisms characteristic gestures mathematically design new interactive interfaces easily natural familiar users
construction projects becoming complex uncertain increased focus sustainability green building partnering way enabling non adversarial environment creates flexible process helps retrofit projects achieving goals purpose paper identify key elements ensure success partnering projects different stakeholders paper seek answer following questions elements used partnering projects link use different partnering elements project success seen client contractor user perspective research carried review partnering literature well investigation partnering projects within norwegian context using case study approach investigated projects new buildings retrofittings preliminary survey additional depth semi structured interviews clients contractors conducted document study also carried supplement survey interviews key partnering elements early involvement value based procurement start workshop identified study analysis revealed partnering elements combination soft elements trust commitment competence help facilitate success stakeholders identified key partnering elements gives practitioners implication partnering elements implemented achieve project success sustainable buildings authors published elsevier ltd
objective investigate effectiveness micro expression training tool mett subtle expression training tool sett help improve non verbal communication skills medical students methods randomized controlled trial participants randomly allocated either training control group pre tested education mett sett baseline training students took second tests class interpreting micro subtle expressions control students took second tests without class results mett pre test scores positively related female gender agreeableness whereas sett pre test scores negatively related age positively related female gender mean mett score increases mean sett score increases observed training whereas control group achieved mean mett score increase second testing increases test scores training group significantly higher control group conclusion mett sett effective simple tools improving micro subtle expression reading skills medical students practice implications mett sett effective improving non verbal communication skills medical students elsevier ireland ltd rights reserved
integration spain european higher education space ehes implantation new university degrees different methodological strategies improve performance teaching learning process taken terms competence framework student personal effort assessment appear educational scene new curricula degrees one debated items among college teachers students attendance classes must compulsory appropriated control mechanisms must teachers include assistance assessment students personal effort etc questions debated discussed analyzed behavior one students group studying electronic automatic control engineering degree universitat politecnica valencia upv third academic course students must course subject digital electronics performed work paper statistical study relating scores obtained students attendance lectures presented likewise proposals school attendance first step achieve competency objectives course performed
aimsthe aim study determine whether allergy status characteristics common cold patients modify effects zinc acetate lozenges methodswe available individual patient data three randomized placebo controlled trials zinc acetate lozenges administered common cold patients used one stage two stage meta analysis estimate effects zinc lozenges resultsthe total number common cold patients majority females eighty percent fell age range years one third patients allergies one stage meta analysis gave overall estimate days days shorter colds zinc acetate lozenge usage two stage meta analysis gave estimate days days reduction common cold duration estimates compared day average duration colds three trials effect zinc lozenges modified allergy status smoking baseline severity common cold age gender ethnic group conclusionsince effects zinc acetate lozenges consistent compared subgroups overall estimates effect seemed applicable wide range common cold patients optimal composition zinc lozenges best frequency administration investigated given current evidence efficacy common cold patients may encouraged try zinc lozenges treating colds
implantable cardiac pacemakers play vital role extending lives patients cardiovascular diseases technique wireless power transfer wpt via magnetic coupling resonance mcr makes possible wirelessly uninterruptedly supply electricity pacemakers external however eddy current metallic pacemaker shell seriously impacts electric energy receiving receiving coils making wpt system operate low efficiency decrease eddy current effect increase wpt efficiency precise implant position receiving coils theoretically experimentally investigated paper electromagnetic model pacemaker wpt system built analytical solution induced voltage across receiving coils derived verified experiments accordingly minimum distance receiving coil pacemaker shell reversely calculated enough induced voltage experimental results show supplied power source khz pacemaker charging system successfully charged lithium ion battery residual capacity within min thickness receiving coil implanted subcutaneously safety charging system electromagnetic thermal simulation results show maximum sar temperature rise tissues degrees respectively results provide theoretical practical support design wireless charging system
based ternary quantum logic circuit tour symmetric weak ternary quantum homomorphic encryption qhe schemes proposed first one qutrit rotation gate qhe scheme constructed second view synthesis general unitary transformation another one qutrit qiie scheme proposed third according one qutrit scheme two qutrit qhe scheme generalized controlled gate constructed generalized aril unitary matrix case finally security schemes analyzed two respects concluded attacker correctly guess encryption key maximum probability thus better protect privacy users data moreover schemes well integrated future quantum remot server architecture thus computational security users private quart information well protected distributed computing environment
background poor educational achievement associated range psychiatric disorders several studies suggest underperformance due cognitive deficits commence disease onset reflect genetic risk disorder however specificity familial contribution cognitive deficit clear analysed lifetime educational achievement psychiatric patients diagnosed schizophrenia bipolar depressive disorder unaffected siblings method register based case control study patients schizophrenia patients bipolar disorder patients depression siblings matched eight population controls patients siblings controls compared highest educational stream completed results lower educational achievement present schizophrenia patients primary school onwards completing primary school odds ratio completing secondary school completing academic education compared patients bipolar disorder depression siblings schizophrenia bipolar depressed patients showed underachievement primary secondary school siblings schizophrenia patients well siblings depressed patients less successful educational achievement secondary school completing academic education schizophrenia siblings depressive disorder siblings conclusions educational underachievement primary school onwards specifically related schizophrenia bipolar disorder depression moreover appears harbinger illness since found siblings results add evidence early cognitive deficits distinct feature schizophrenia phenotype
background changes reproductive hormones menopause associated accumulation intra abdominal adipose tissue iaat subclinical indicator cardiometabolic disease risk independent reproductive hormones unhealthy lifestyle contributes iaat gain women southside health fitness wishfit study aims develop lifestyle approach slowing iaat accumulation women begin menopausal transition methods primary aim develop conduct proof concept test multi component multi level behavioral intervention targeting jointly physical activity diet psychological wellbeing participants attend group sessions years experiment healthy living experiential didactic learning cultivate health network draw community resources sustain change primary endpoint year iaat progression assessed using computerized tomography behavioral targets treatment secondary endpoints evaluated months change social networks community support assessed years results wishfit recruited pre peri menopausal caucasian african american women mean age yrs bmi african american baseline iaat iaat physical activity bmi self reported family income resilience differed ethnicity baseline conclusions wishfit multi component multi level intervention aimed producing sustained improvement physical activity diet psychological well early menopausal transition slow menopause related accumulation iaat provides model process developing behavioral treatment manage chronic disease authors published elsevier inc open access article license
objective children problematic severe asthma achieving adequate control asthma difficult aim prospective observational study evaluate effects intensive multidisciplinary inpatient treatment multiple outcome variables children problematic severe asthma methods participants children problematic severe asthma mean age years treated tertiary care clinics high altitude switzerland sea level netherlands parents mothers fathers primary outcome variable childhood asthma control test act outcome variables forced expiratory volume sec fev fractional concentration exhaled nitric oxide feno quality life paqlq children coping ucl parents report behavioral problems cbcl parenting stress psi nosi evaluations taken pre treatment post treatment months follow median treatment duration days median follow interval days results percentages children showing controlled asthma act pre treatment post treatment follow vast majority children showed improvement act showing deterioration act feno quality life behavioral problems improvements post treatment highly significant improvements generally remained functional level follow children coping parenting stress parents change conclusions improvement asthma control outcome variables suggests multidisciplinary inpatient treatment effective approach heterogeneous group children asthma remained uncontrolled secondary care wiley periodicals inc
paper describes development simulation model state space representation class microwave heating model assumptions thermodynamics mechanism one dimensional heating model rectangle waveguide derived combining lambert law heat conduction equation introducing spatial differential operator inhomogeneous thermal conduction equation one dimensional heating model form partial differential equations pde divided finite dimensional slow one infinite dimensional complement provides application galerkin method transform pde state space form simulation state space model shown trend distribution temperature good agreement traditional numerical model
study examines school time program targeting elementary aged youth populations typically underrepresented science fields primarily african american hispanic english language learner participants program aimed foster positive attitudes toward science among youth engaging growing plants hydroponically water without soil participants attitudes toward science including anxiety desire self concept examined pre post survey data course afterschool program three separate sites data showed participants anxiety decreased desire increased male female participants program self concept increased female participants three sites change significantly male participants participants first language english spanish factor attitude outcomes primarily positive outcomes suggest hydroponics useful educational platform engaging participants garden based programming year round particularly settings physical space climate conduct outdoor gardening similarities positive attitude outcomes three sites despite differences format implementation instructor background experience suggest program resilient variation context understanding aspects program facilitated positive outcomes varied contexts could useful design future programs
fine grained image recognition computer vision task filled challenges due imperceptible inter class variance large intra class variance drawing increasing attention manual annotation utilized effectively enhance performance task extremely time consuming expensive recently convolutional neural networks cnn achieved state art performance image classification propose fine grained image recognition framework exploiting cnn raw feature extractor along several effective methods including feature encoding method feature weighting method strategy better incorporate information multi scale images improve recognition ability besides investigate two dimension reduction methods successfully merge framework compact final image representation based discriminative compact framework achieved state art performance terms classification accuracy several fine grained image recognition benchmarks based weekly supervision
sexual education plays essential role teaching youth healthy lifestyles creating mature relationships schools textbooks common educational resource content utmost importance correct information create preconditions empowerment adolescents making healthy decisions avoiding risky sexual behaviour purpose study evaluation content textbooks areas human sexuality procreation order find extent textbooks promote healthy lifestyles positive attitude toward fertility function well avoidance risky sexual behaviour among adolescent students research methods study sample consisted textbooks biology subject year old students lithuania content analysis evaluated extent books demonstrated reliable scientific information comply principle norms moral values goals general programme health sexuality education preparation family life lithuania findings textbooks presented inaccurate information areas studied correct information human fertility system fertility awareness mechanism action hormonal contraception sexuality presented mostly biological function evaluation textbooks allows stating content evaluated biology textbooks comply provisions norms general programme health sexuality education preparation family life may unsuitable healthy lifestyle education published future academy www futureacademy org
ternary content addressable memory tcam based search engines generally need priority encoder select highest priority match entry resolving multiple match problem due care features tcam contemporary network security tcam based search engines widely used regular expression matching across multiple packets protect attacks viruses spam however use results increased energy consumption pattern updates search operations instead using pes determine match solution three phase search operation utilizes length information matched patterns decide longest pattern match data paper proposes promising memory technology called priority decision memory pdm eliminates need pes removes restrictions ordering implying patterns stored arbitrary order without sorting lengths moreover present sequential input state sis scheme disable mass redundant search operations state segments basis analysis distribution hex signatures virus database experimental results demonstrate pdm based technology improve update energy consumption nonvolatile tcam nvtcam search engines energy search engines used reorder adopting sis based method avoid unnecessary search operations tcam array search energy reduction around nvtcam search engines
abnormalities nonverbal communication hallmark schizophrenia results studies using symptom rating scales suggest abnormalities profound sds occur across virtually every channel vocal expression computerized acoustic analytic technologies used overcome practical psychometric limitations symptom rating scales found much benign isolated abnormalities better understand vocal deficits schizophrenia advance acoustic analytic technologies clinical research applications examined archived speech samples separate studies using different speaking tasks patient control sought use principal component analysis pca identify independent vocal expression measures large set variables quantify patients schizophrenia abnormal respect variables evaluate impact demographic contextual factors study site speaking task examine relationship clinically rated psychiatric symptoms vocal variables pca identified independent markers vocal expression vocal variables varied considerably function context many associated demographic factors controlling context demographics meaningful differences vocal expression patients controls within patients vocal variables associated range psychiatric symptoms though pause length significantly associated clinically rated negative symptoms discussion centers explaining apparent discordance clinical computerized speech measures
objective spondyloarthritis spa second frequent inflammatory rheumatic disease characterized spinal involvement peripheral arthritis enthesitis marked pain stiffness fatigue fibromyalgia may associated spa shares common symptoms aimed determine influences assessment spa disease activity mainly dependent patient based outcome measures bath ankylosing spondylitis disease activity index basdai ankylosing spondylitis disease activity score asdas methods single center cross sectional study included consecutive patients spa according assessment spondyloarthritis international society criteria diagnosed according american college rheumatology criteria patient characteristics basdai asdas reactive protein crp bath ankylosing spondylitis functional index bath ankylosing spondylitis metrology index medical outcomes study short form questionnaire recorded compared results study included patients spa axial peripheral forms eighteen patients presented concomitant axial spa peripheral spa demographic characteristics differ except sex female predominance group marked peripheral forms basdai higher patients median iqr whereas asdas crp significantly different median iqr nevertheless median asdas crp corresponded high disease activity patients spa compared moderate activity non patients conclusion frequent comorbidity patients spa especially peripheral forms patients spa disease activity may overestimated measured basdai lesser extent asdas crp overestimation could lead inappropriate treatment escalation
actual perceived self enhancement entail differing social impressions interpersonal evaluations actual self enhancement represents unduly positive self views gauged objective criterion case scores whereas perceived self enhancement involves extent individual seen informants peers observers self enhancing online survey laboratory experiment round robin study tested effects actual perceived intellectual self enhancement informant rated emotional stability social attractiveness social influence actual self enhancers rated emotionally stable socially attractive socially influential high perceived self enhancers judged socially influential whereas low moderate perceived self enhancers deemed emotionally stable socially attractive privately entertained illusory positive even extreme self beliefs confer social benefits whereas perceived self enhancing buys social influence cost despised copyright john wiley sons ltd
care coordination programmes important aspect hiv management whose success depends largely hiv primary care provider pcp case manager collaboration factors influencing collaboration among hiv pcps case managers remain studied study objective test existing theoretical model interprofessional collaborative practice determine factors play important role facilitating collaboration self administered anonymous mail survey sent hiv pcps case managers new york city adapted survey instrument elicited information demographic contextual perceived social exchange trustworthiness role specification relationship initiation characteristics dependent variable perceived interprofessional practice constructed validated scale sequential block wise regression model specifying variable entry order examined relative importance group factors individual variables analysis showed social exchange factors dominant drivers collaboration relationship initiation important predictor interprofessional collaboration additional influential factors included organisational leadership support collaboration practice settings frequency interprofessional meetings addressing factors influencing collaboration among providers help public health programmes optimally design structural hiring training strategies foster effective social exchanges promote collaborative working relationships
instructors undergraduate graduate courses materials science laboratory section employ hands sessions students understanding key materials behavior principles typical solid mechanics laboratory session exposes students topics tensile torsion hardness fatigue fracture testing procedures well associated properties like even though observing different modes material deformation rupture response first hand fosters better mastery course content limitations available face time students course budget availability test devices etc obstacles integrating software tools simulate mechanical testing represents alternative approach potentially transform enhance students learning outcomes identical graphical user interface used conducting virtual physical testing materials software tools aid classroom laboratory student self study subjects material plastic yielding stress strain relationships fatigue crack growth fracture tools used laboratory perform physical testing integrated virtual physical curriculum prepares student test setup execution data analysis makes laboratory experience efficient also instructive gaining understanding value limitations modeling approaches describing material behavior
objectives determine alexithymia affect recognition empathy differences participants without traumatic brain injury tbi amount affect recognition variance explained alexithymia amount empathy variance explained alexithymia affect recognition participants sixty adults moderate severe tbi age gender matched controls procedures participants evaluated alexithymia difficulty identifying feelings difficulty describing feelings externally oriented thinking facial vocal affect recognition affective cognitive empathy empathic concern perspective taking respectively results participants tbi significantly higher alexithymia poorer facial vocal affect recognition lower empathy scores tbi participants facial vocal affect recognition variances significantly explained alexithymia respectively however majority variances accounted externally oriented thinking alone affect recognition alexithymia significantly accounted cognitive empathy majority variance primarily explained externally oriented thinking affect recognition alexithymia explain affective empathy conclusions results suggest people tendency avoid thinking emotions externally oriented thinking likely problems recognizing others emotions assuming others points view clinical implications discussed
empathy may defined ability share understand others emotional state multi faceted construct relies discrete psychological processes specific neural correlates psychological processes might impaired mental disorders schizophrenia autism spectrum disorders borderline personality disorder mood disorders among disorders psychopathy mainly characterized lack empathy others distress associated amygdala hypo reactivity context doctor patient relationships clinical empathy also encompasses physician ability communicate understanding emotional state patient however sharing emotional states may elicit compassion fatigue burnout symptoms among physicians medical students reduce empathic capacities decline capacities indeed observed medical training perspective taking may protect physicians negative effects allowing show sustained empathic concern interventions promote empathy among medical students target communication skills humanist values communication skill may depend humanist values grow
antisocial personality disorder aspd borderline personality disorder bpd common conditions forensic settings present high rates violence personality traits related five factor model personality domains neuroticism agreeableness shown relationship physical aggression nonclinical general psychiatric samples aim present investigation examine association personality traits violence aggression aspd bpd results revealed trait anger hostility predicted self reported physical aggression aspd bpd subjects beta number violent convictions subsample aspd participants beta preliminary results suggest high anger hostility associated physical aggression bpd aspd application validated self report personality measures could provide useful easily accessible information supplement clinical risk assessment violence conditions
health risks children caused bacteria indoor environments attracted much attention recent years many harmful bacteria children greater health risks adults environment investigate association children health risks distribution concentration bacteria particulate matter smaller indoor outdoor air three kindergartens hong kong quantitative polymerase chain reaction used determine concentration bacteria terminal restriction fragment length polymorphism method targeting ribosomal rna genes used predict phylogenetic airborne bacterial community structures bacterial concentrations indoors higher outdoors three kindergartens obvious differences found statistical analysis showed different schools significantly different concentrations abundance bacteria schools downtown kowloon greatest reaching cells per however results showed significant differences microbial populations obtained indoors obtained outdoors dominant genera similar among six samples results suggest majority inhalable bacteria harmless humans small fraction microbial pathogens identified relative abundance appeared increase concentration particulate matter pollution increased analysis bacteria give important clues regarding exposure kindergarten children bacteria indoor outdoor air elsevier ltd rights reserved
depression common often harmful disorder frequently associated winter season research shown link type diabetes mellitus depression furthermore diabetics depression higher rate adverse outcomes little published regarding seasonality depression diabetics case report described article concerns year old woman type diabetes history winter depression current evidence based management options reviewed
objective investigate association hla susceptibility disease severity markers extent atherosclerosis patients psoriatic disease methods white patients psoriatic arthritis psa psoriasis without psa psc recruited ultrasound carotid arteries performed size atherosclerotic plaque measured resulting score total plaque area tpa represented extent atherosclerosis hla genotyping performed using sequence specific oligonucleotide probes association hla susceptibility severity markers psc psa severity atherosclerosis assessed ordinal logistic regression models adjusted age sex cardiovascular risk factors results study involved patients psa psc least atherosclerotic plaque hla hla associated severe atherosclerosis age sex adjusted respectively hla associated less severe atherosclerosis associations remained statistically significant adjusting risk factors higher levels erythrocyte sedimentation rate esr associated severe atherosclerosis age sex adjusted hla positive well hla positive patients higher levels esr time conclusion hla alleles associated higher burden atherosclerosis patients psoriatic disease association may mediated higher level systemic inflammation
closed form iterative procedure synthesizing quasi arbitrary phase responses cascaded microwave section pass phasers presented synthesis consists mapping transmission poles cascaded section structure onto transmission poles specified transfer function latter poles computed using closed form polynomial generation method real complex transmission poles specified transfer function realized using sections different lengths different couplings coefficients proposved synthesis validated full wave analysis measured multilayer prototypes copyright john wiley sons ltd
present multi level formation model complex software systems previous works extract software systems software networks studies usually investigate software networks class level contrast works treatment software systems multi level networks realistic particular software networks organized three levels granularity represents modularity hierarchy formation process real world software systems importantly simulations based model generated realistic structural properties software networks power law clustering modularization basis model structure software systems effects software design principles explored could helpful understanding software evolution software engineering practices
underwater exploration become active research area past decades image enhancement one challenges computer vision based underwater researches degradation images underwater environment scattering absorption main causes underwater environment make images decrease visibility example blurry low contrast reducing visual ranges tackle aforementioned problems paper presents novel method underwater image enhancement inspired retinex framework simulates human visual system term retinex created combinations retina cortex proposed method namely lab msr achieved modifying original retinex algorithm utilizes combination bilateral filter trilateral filter three channels image cielab color space according characteristics channel real world data experiments carried demonstrate degradation characteristics underwater images different turbidities competitive performance proposed method authors published elsevier
network security management big challenge network administrators due increasing vulnerabilities vulnerabilities weakness network allow malicious attackers access resources controlled organization keep networks secure network administrators aware vulnerabilities attacker gain access paper considered attack graph describes attacker compromise security network generate attack graph multihost multistage vulnerability analysis mulval tool used generated graphs tool logical attack graphs graphs based logical programming based dependencies among attack goal configuration information taken two security metrics namely exploitability metric impact metric analyze risk associated network preliminary results suggest size network impact vulnerability network
goal present study show possible estimate online individual torques applied wheel automotive vehicle using unknown input observer together simple nonlinear state space model necessary measurements steering angle usual rotation speed wheel plus vertical load centre wheel study anticipates affordability new generation wheel bearing embedded measurements transmitted forces successful simulated experimentations using realistic simulator shown validations done using classical case studies longitudinal lateral coupled dynamics present limits possible improvements proposed method also discussed
background fecal incontinence represents large source morbidity challenging clinical problem manage interstim approved treat little known adoption sought characterize patterns use interstim since food drug administration approval methods new york state sparcs database used evaluate interstim use primary endpoint number successful implantations interstim secondary endpoints included device removal median time removal device day infection rates percentage procedures performed surgeon specialty geographic location results total patients underwent stage interstim total patients underwent stage yielding trial period failure rate majority patients underwent successful implantation female white twenty nine patients underwent device removal median duration days estimated risk removal median follow years colorectal surgeons comprised providers followed gynecologic urologic surgeons total providers performed procedures highest volume providers performed procedures conclusions interstim used wide variety providers new york state although high volume providers performed majority procedures white female patients medicare common recipients interstim work must done develop strategies improving access technology determine whether volume relates outcomes
decades research shown positive life events contribute remission recovery depression however unclear positive life events generated study sought understand personality strengths could predict positive life events aid alleviation depression tested longitudinal mediation model gratitude meaning life lead increased positive life events turn decreased depression sample consisted adult participants different countries completed online surveys five timepoints higher levels gratitude meaning life predicted decreases depression months time increases positive life events mediated effects personality strengths depression months however months goal pursuit positive emotions theorized driving forces behind gratitude meaning life effects positive life events used hedonic treadmill interpret short term impact positive life events depression findings suggest potential gratitude meaning life interventions facilitate depression remission
study assesses two approaches combine observations active passive satellite microwave instruments soil moisture data assimilation system first approach labeled joint retrieval assimilation single soil moisture product simultaneously retrieved active passive microwave observations assimilated nasa catchment land surface model second approach labeled separate retrieval assimilation separate soil moisture products retrieved active passive microwave observations simultaneously assimilated model approaches neural network used retrieve soil moisture passive microwave amsr brightness temperatures active microwave ascat backscatter observations spatially distributed ensemble kalman filter used assimilation contiguous united states august september analysis skill assimilation approaches evaluated situ observations scan stations compared model open loop assimilation skill averaged across sites skill obtained assimilation experiments similar surface soil moisture average correlation anomaly correlation respectively metrics slightly better open loop correlation anomaly correlation root zone soil moisture estimates assimilation also slightly improved compared open loop average correlation average anomaly correlation locally differences skill values two assimilation experiments related differences skill assimilated retrieval products well differences captured observation errors specified data assimilation elsevier inc rights reserved
paper shows results simulation high spectral efficiency modulation coding scheme msc consist modulation psk pcm error correction reed solomon code comparison high spectral efficiency schemes different radio link signal distortion ways proposed msc show close result psk fec comparison qam fec proposed msc showed faster performances degradation non ideal transmission conditions overall due inherent features like low envelope amplitude variation simple demodulation algorithm moderate hardware complexity msc psk pcm applied high speed satellite radio downlink effectively
machine learning continuing gain popularity due ability solve problems difficult model using conventional computer programming logic much current past work focused algorithm development data processing optimization lately subset research emerged explores issues related security research gaining traction systems employing methods applied secure adversarial environments one machine learning biggest benefits data driven versus logic driven approach also weakness data models rely corrupted adversaries could maliciously influence systems address drift data distribution changes using training online learning work focused exploring resilience various machine learning algorithms data driven attacks paper present initial findings using monte carlo simulations statistical analysis explore maximal achievable shift classification model well required amount control data
etiology men lower urinary tract storage voiding symptoms involves contribution detrusor outlet treatment benign prostatic enlargement bpe benign prostatic obstruction bpo standard alpha adrenergic blockade alpha reductase inhibitor therapy may leave population men persistent bothersome urinary storage symptoms abundance adequately powered randomized placebo controlled trials indicate use antimuscarinics beta adrenergic agonists either alone combination standard bpe bpo therapy leads improvement storage symptoms time metrics associated urinary emptying maximumflow rate post void residual urinary volume incidence treatment associated urinary retention appear stable significantly impacted addition antimuscarinics
dutch adolescent second generation migrants increased risk becoming marginalized developing problem behavior tested effectiveness dutch multi component empowerment program power aims prevent problems hypothesized positive intervention effect onparticipants sense mastery coping skills activities conduct problems prosocial behavior conducted cluster randomized controlled trial including pretest posttest intervention condition waitlist control condition analyses showed power effective influencing youngsters participation activities like sport hobbies casual work implemented high fidelity power also influenced level conduct problems well coping style however accurate registration implementation process would helpful program potentially improved clearly specifying components program adapted must delivered intended elsevier ltd rights reserved
chapter much process reverse engineering particular drug delivery system presents materials science materials engineering concepts went design testing ltsl including roles components make composite membrane molecular nanostructures form might influence already anomalous permeability phase transition bilayer thermally sensitive drug delivery system leads ultrafast heat mediated triggered intravascular release pre loaded doxorubicin release drug penetrating deep tumor interstitium controlled long mild hyperthermia applied relation liposome administration formulation thermodox used completed patient phase iii human clinical trial liver cancer heat study phase trial chest wall recurrence cancer dignity study also phase trial patients colorectal liver metastases ablate study bench bedside story addresses overcoming limitations nanoparticle drug delivery also importance research implementation translation clinic additional research preclinical studies underway including exploring use high frequency ultrasound hifu heating modality range drugs imaging agents biological modifiers poised encapsulation ltsl could provide new paradigm drug agent delivery treatment localized tumors rapid triggered drug release tumor bloodstream deep penetration drug tumor tissue unfortunately phase iii trial liver cancer failed meet required endpoints progression free survival pfs data still analyzed preclinical clinical research shows essential future trials particular formulation whole tumor heated desired temperature degrees maintained temperature thermodox infused minimum min probably hour heat first infuse drug
rainwater harvesting systems rhs increasingly used buildings mitigate water shortage rising prices centralised water supply notwithstanding benefits rhs may also promote adverse impacts mainly related high consumption energy context energy intensity unit energy per unit water crucial parameter assessing environmental feasibility different rhs however recently attention drawn connection water energy consumption prompted increasing importance water security energy efficiency economic feasibility connection known water energy nexus increasingly acknowledged key principal water planning objective study twofold review energy intensity data reported rhs outline strategies enhance energy performance rhs buildings reviewed literature median energy intensity theoretical studies kwh considerably lower described empirical studies kwh implies theoretical assessments energy intensity may sufficiently consider energy used pump start ups standby mode well true motor pump energy efficiency however extent difference may also represent amount energy reduced optimising rhs design operation comparing rhs conventional town water supply systems reviewed empirical studies showed rhs tend three times energy intensive although optimised rhs comparable values ultimately predominately local characteristics rainwater demand building type single storey multi storey rhs sub systems design potable water plumbing system design town water energy intensity among factors determine whether environmental economic performances rhs acceptable elsevier ltd rights reserved
article present estimates diurnal semidiurnal harmonics variations integrated water vapor content iwv according data gps stations volga ural region russia amplitudes diurnal harmonics maximal summer reach values time maximum diurnal harmonic typically period semidiurnal harmonics largest amplitudes spring autumn exceed comparison diurnal cycle gps data era interim reanalysis revealed significant differences phase established result evaporation underlying surface convective lifting moist air summer diurnal variations iwv surface density water vapor antiphase diurnal cycle iwv determined surface air temperature summer less seasons noted maximal amplitudes diurnal harmonic iwv observed stations located windward side mountains
role nanoparticles nps enhancement thermal wettability adsorption properties chitosan inspired loading caco modified diacid based phenyl aniline within ultrasound agitation diameter caco extended thermal test caco nanocomposite revealed temperature weight loss increased degrees twice value pure polymer wettability property caco ncs transformed hydrophilicity hydrophobicity caco nps concentration increased due decrease accessibility polar groups water caco selected adsorbent uptake metal ions wastewater showed maximum adsorption capacity respectively attributed strong complexation reaction metal ions functional groups obtained
major objective work describe dynamic thermal behavior thermoelectric generators refrigerators effect hyperbolic heat conduction model practical situations devices work transient operating conditions due time change imposed current voltage hot cold temperatures results transient temperature distributions obtained different parameters coefficient performance obtained function time increasing current flow
low velocity impact cratering experiments conducted sloped granular targets study effect slope angle theta crater shape scales use two types granular matter sand glass beads former larger friction coefficient tan theta theta angle repose experiments show theta increases crater becomes shallower elongated direction slope furthermore crater floor steepens upslope side thick rim forms downslope side thus forming asymmetric profile high speed images show features results ejecta dispersed farther towards downslope side subsequent avalanche buries much crater floor asymmetric ejecta dispersal explained combining model ballistic model using topographic maps craters classify crater shape regimes iii transition increasing theta full rim crater broken rim crater depression iii critical theta regime transitions larger sand compared glass beads collapse close values use normalized slope theta cap tan theta tan theta similarly derive theta cap dependences scaled crater depth length width ratios collapse results different targets impact energies compare crater profiles formed experiments deep craters asteroid vesta find scaled profiles nearly overlap many similar depth length ratios suggests vestan craters may also formed gravity regime formation process approximated granular flow similar effective friction coefficient elsevier inc rights reserved
reduced scale shaking table testing useful tool understanding seismic behavior geosynthetic reinforced soil walls paper presents results series reduced scale shaking table tests eight different configurations effects change peak ground acceleration reinforcement length spacing model scale treatment top two facing block layers accelerations wall face maximum displacements wall face shaking permanent displacements strains reinforcement investigated maximum accelerations measured wall face shaking increased bottom top geotextile length spacing affect maximum accelerations face displacements geotextile length met minimum requirements established design procedures significant permanent displacements observed decreasing geotextile length increasing geotextile spacing increased geotextile strains geotextile long enough provide anchorage beyond potential failure surface american society civil engineers
doctor shopping caused increase medical expense potential receive duplicate medications suffer adverse drug reactions carried population based retrospective study aimed examining user patterns traditional chinese medicine tcm ambulatory care taiwan retrieved complete tcm ambulatory visit datasets year national health insurance database taiwan defined patients whose distribution tcm physician numbers scored percent equal five tcm physicians within one year tcm doctor shoppers total subjects paid tcm visits year subjects visited five including tcm physicians classified tcm shoppers prevalent diagnostic grouping upper respiratory infections sprains strains men lower odds ratio among tcm shoppers women confidence interval younger people less likely tcm shoppers people ors tcm shoppers higher among veterans low income patients conclusion health education potential drug interactions iatrogenic health risks incurred doctor shopping addressed high risk patients
recently plug hybrid electric vehicles phev becoming attractive internal combustion engine vehicles icev hence design modeling charging stations css vital importance distribution system level paper new formulation phev charging stations presented strategic presence wind power generation wpg study considers constraints system losses regulatory voltage limits charge discharge schedule phev based social behavior drivers appropriate placement phev charging stations electricity grid role css wpg units must correctly assessed optimize investment operation cost whole system however wind generation owners wgos different objective functions might contrary objectives distribution system manager dsm assumed aggregating management charge discharge program phevs smartly carried dsm paper presents long term objective model optimal planning phev charging stations wpg units distribution systems simultaneously optimize two objectives namely benefits dsm wgo also considers uncertainty load growth electricity price phev access charging station using mont carlo simulation mcs method initial state charge uncertainty also modeled based scenario approach phev batteries wind turbine power generation using weibull distribution non dominated sorting genetic algorithm nsga used solve optimization problem simulation conducted nine bus system elsevier ltd rights reserved
objective overactive bladder syndrome urinary frequency urgency without urge incontinence absence local pathological factors since multiple causes responsible oab requires proper diagnosis comprehensive management decades flavoxate globally used accepted molecule urologists general physicians symptomatic treatment oab spite extensive use oab meta analysis available publications efficacy safety tolerability flavoxate conducted paper evaluates strength evidence clinical effectiveness safety tolerability flavoxate symptomatic treatment oab methods review articles original studies case reports medline cochrane library google scholar scirus internal repository etc searched using keyword flavoxate primary outcome comparative data flavoxate versus comparator extracted following parameters overall efficacy side effect profile similarly secondary outcome data extracted flavoxate per overall efficacy frequency urinary incontinence mixed incontinence nocturia unpleasant urination stranguria side effect profile analyzed using comprehensive meta analysis cma software version results current meta analysis relevant published studies considered clearly demonstrated flavoxate improved clinical efficacy placebo emepronium propantheline phenazopyridine conclusions amongst interventions studied flavoxate effective well tolerated almost negligible side effects making worthy consideration treatment oab
eyewitness memory widely believed unreliable high confidence eyewitness misidentifications played role dna exonerations wrongfully convicted men women forensically relevant laboratory studies often reported weak relationship eyewitness confidence accuracy memory sufficiently malleable infrequently people including eyewitnesses led remember events differently way events actually happened light evidence many researchers agree confidence statements made eyewitnesses court law particular high confidence often express trial discounted disregarded altogether confidence statements made eyewitnesses time initial identification lineup much opportunity memory contamination occur considerable body recent empirical work suggests confidence may highly reliable indicator accuracy time fits longstanding theoretical models recognition memory counterintuitively appreciation fact could protect innocent defendants wrongfully convicted eyewitness identification reform proposed date
study investigated measurement structure bem sex role inventory bsri different factor analysis methods previous studies validity applied exploratory factor analysis efa examine bsri aimed assess psychometric properties construct validity item short form bsri sample administered older adults wave international mobility aging study imias used cronbach alpha assess internal consistency reliability confirmatory factor analysis cfa assess psychometric properties efa revealed three factor model confirmed cfa compared original two factor structure model results revealed two factor solution instrumentality expressiveness satisfactory construct validity superior fit data compared three factor solution two factor solution confirms expected gender differences older adults item bsri provides brief psychometrically sound reliable instrument international samples older adults
power amplifier end radio transmitter provides power receiving antenna amplifier energy emission link module also strongest non linear module improve efficiency extend battery life improve linearity improved data efficiency linearity efficiency class power amplifier good compromise widely used band gaas fet power amplifier class presents selected work points impedance matching method achieve high efficiency discussed amplifier input loop impedance converting circuit transistor amplifier circuit design ideas output circuit impedance conversion circuit design important analog signal processing circuit class high power amplifier simulation experimental results show amplifier range ghz similar ghz pdb dbm gain mesh distortion rate low
majority research staphylococcus field dedicated understanding staphylococcus aureus infections contrast limited information infections coagulase negative staphylococci cons host responds epidermidis member coagulase negative staphylococci important commensal organism human skin mucous membranes emerging evidence benefit human health fighting harmful microorganisms however epidermidis cause opportunistic infections include particularly biofilm associated infections indwelling medical devices often disseminate bloodstream fact epidermidis frequent cause nosocomial sepsis increasing use medical implants dramatic shift patient demographic population recent years contributed significantly rise epidermidis infections furthermore treatment complicated emergence antibiotic resistant strains today epidermidis major nosocomial pathogen posing significant medical economic burdens review present current understanding mechanisms host defense prototypical cons species epidermidis commensal skin mucous membranes biofilm associated infection sepsis
paper describes design intelligent based nonlinear controller three dimensions joint dental robot manipulators presence uncertainty three dimension joint dental robot manipulator important challenges nonlinearity multi input multi output mimo uncertainty dynamic formulation coupling effect eliminate effect challenge linear filter pid controller introduce research however controller advantages certain condition uncertainty problems improve technique presence uncertainty minimum rule base pid like fuzzy controller introduced method reduces rise time steady state error improves trajectory performance uncertain condition stability robustness improve proposed method well reduce number rule base
slotted liners flow control devices widely used injection production wells thermal oil sands recovery operations steam assisted gravity drainage devices slots cut well regular intervals around along well dimensions tend fractions several millimeters gap twenty centimeters long along pipe key benefits offered slotted liners among economical solutions sand control well bore stability well manufacturing slotted liners several design parameters including slot density pattern slot opening size shape must chosen provide optimum inflow outflow performance reservoir due complexity deriving parameters analytically experimentally examined impact design parameters steam injection using realizable epsilon turbulence computational fluid dynamic model slotted liner section coupled reservoir flow domain outside well governed modified darcy law accounts inertial effects results reveal slot open area affects flow distribution reservoir role drive forces changes flow viscous pressure forces dominant slot upstream area inertial forces downstream slot pressure viscous forces reservoir elsevier ltd rights reserved
present design fabrication self powered autonomous fringing field capacitive sensor measure soil water content sensor manufactured using conventional printed circuit board includes porous ceramic read sensor use circuit includes khz triangle wave generator amplifier precision rectifier microcontroller terms performance sensor capacitance measured laboratory prototype increases volumetric water content porous ceramic changed resulting sensitivity per unity change repeatability tests capacitance measurement showed theta sensor root mean square error average current consumption system sensor signal conditioning circuit less demonstrates suitability powered energy harvesting systems developed complete irrigation control system integrates sensor energy harvesting module composed microgenerator installed top micro sprinkler spinner converter circuit charges supercapacitor energy harvesting module operates micro sprinkler spinner irrigating soil supercapacitor fully charged first irrigation first irrigation supercap fully charged system operate powered supercapacitor approximately days without energy harvested
lipid fraction egg powder may affected storage conditions due development oxidative rancidity caused polyunsaturated fatty acids study evaluated egg powders enriched antioxidants tocopherol catechin lycopene butylated hydroxyanisole bha conjugated dienes day period malonaldehydes day period degrees presence lycopene bha increases total phenolic compounds enriched egg powders bha exhibits antioxidant activity quantified abts assay egg powders enriched antioxidants show reduction conjugate diene production compared controls effect storage temperature observed however production malonaldehyde greater stability observed degrees catechin effective reducing oxidation storage results show natural antioxidants used egg powder instead synthetic compounds reduce malonaldehyde production storage elsevier ltd rights reserved
fashion industry one flourishing fields visual applications due importance concept look fashion advanced applications computer graphics sensing may fruitfully exploited existence low cost solutions similar fields ones empower domestic video games market suggest analogous low cost solutions viable foster innovation even small medium enterprises paper current state development vmannequin dynamic user mimicking user enacted virtual mannequin software solution presented order allow users designing dress concepts application simulate creation fitting clothes virtual models interaction sensor based order simplify user interface create richer involvement inside application
although shale gas become important source natural gas problems associated water pollution producing high salinity wastewater tds membrane distillation applied treat wastewater may suffer fouling due scale formation accordingly study focused use antiscalants retard scale formation process treatment high salinity wastewater experiments performed using laboratory scale direct contact dcmd system seven different antiscalants applied simplified synthetic wastewater results analyzed using simple theoretical model found abilities retard scale formation different different antiscalants difference chemical structures antiscalants attributed changes effect scale prevention moreover mechanisms flux decline seem different presence antiscalants surface blockage also internal pore blocking occurred operation dominant fouling mechanism changed addition antiscalants
travelling new environment people make quick judgements local conditions paper explores idea judgements affected travel mode use hypothesise drivers generate superficial impression things observe walk exposed less information prediction based social psychological research demonstrates information becomes available thin slices affects superficial judgements survey study demonstrated perceptions less affluent area indeed negatively related driving positively related walking live perceptions neighbouring affluent area positively related driving two experimental studies demonstrated explicit implicit attitudes towards group young people ambiguous social situation negative viewed perspective car user particular relation pedestrian perspective findings suggest mode use may affect communities influencing social judgements elsevier ltd rights reserved
purpose aim study investigate association use diseasemodifying antirheumatic drugs dmards diabetes mellitus patients ankylosing spondylitis rheumatoid arthritis psoriasis psoriatic arthritis psa patients methods retrospective cohort study used nationwide population based administrative database enroll cases psa initiated treatment anti tumor necrosis factor anti tnf drugs nonbiologic dmards multivariable analysis used estimate effect different therapies risk results incidence rates per person years users anti tnf drugs users cyclosporine csa users hydroxychloroquine hcq users nonbiologic dmards compared users nonbiologic dmards multivariate adjusted hazard ratios ahrs significantly lower used anti tnf drugs hcq ahr confidence interval used hcq alone ahr used anti tnfs without hcq ahr csa ahr conclusion ahr lowest patients psa initiated treatment anti tnf agent concomitant hcq followed hcq users used anti tnf agents without hcq nonbiologic dmards similar risk
background seronegative joint diseases characterized lack well defined biomarkers since autoantibodies elevated calprotectin damage associated molecular pattern damp released activated phagocytes high levels found seronegative arthritides study investigated biomarker potential systemic local levels proteins assess joint inflammation joint destruction experimental model seronegative arthritis methods serum levels various cytokines monitored disease development interleukin receptor antagonist mice using elisa multiplex bead based immunoassay correlated macroscopic microscopic parameters joint inflammation bone erosion cartilage damage local expression matrix metalloproteinase mmp mediated cartilage damage ankle joints investigated immunohistochemistry addition local activated mmps monitored vivo optical imaging using anti specific tracer activated mmps results serum levels significantly increased mice correlated macroscopic joint swelling histological inflammation serum levels pro inflammatory cytokines correlate joint swelling addition early serum levels prognostic disease outcome later stage increased serum levels reflected increased expression within ankle joint visualized molecular imaging next inflammatory processes serum also correlated histological parameters bone erosion cartilage damage addition arthritic mice increased synovial expression showed increased cartilage damage coincided mmp mediated neoepitope expression vivo imaging activated mmps conclusions expression mice strongly correlates synovial inflammation bone erosion cartilage damage underlining potential systemic local biomarker seronegative arthritis assessing inflammation also assessing severity inflammatory joint destruction
intrinsic ill posed nature inverse problem near infrared imaging makes reconstruction fine details objects deeply embedded turbid media challenging even large amounts data provided time resolved cameras addition reconstruction algorithms type measurements suitable highly symmetric geometries rely linear approximation diffusion equation since numerical solution fully non linear problem computationally expensive paper show problem practical interest successfully addressedmaking efficient use totality information supplied time resolved cameras set aside goal achieving high spatial resolution deep structures focus reconstruction complex arrangements large regions show numerical results based combined approach wavelength normalized data prior geometrical information defining fully parallelizable problem arbitrary geometries time resolved measurements fast reconstructions obtained using diffusion approximation monte carlo simulations parallelized multicore computer gpu respectively
homotopy renormalisation method global approximate solutions falkner skan equation von karma problem rotating disk infinite viscous fluid obtained homotopy renormalisation method simple powerful finding global approximate solutions nonlinear perturbed differential equations arising mathematical physics
paper explores effect video game content context experience cooperative behavior three research studies study cross sectional correlation study exploring relationship video game team play frequency pro social behavior study game content violent video game neutral video game game context single play team play design dependent variable cooperative behavior study single factor design experiment examines effect gaming experience cooperative behavior collaborative context main findings team play frequency positive correlation pro social behavior pro social video game exposure significantly predicted pro social behavior collaborative play found significantly increase cooperation violent neutral video games however level gaming experience tended moderate relationship collaborative play level cooperation elsevier ltd rights reserved
introduction behcet disease classified among vasculitides aim review put together different known reports order help reader better understand disease avoid frequent misdiagnosis decide best treatment areas covered epidemiology rare seen along silk road turkey iran clinical manifestations oral aphthosis seen patients genital aphthosis skin pseudofolliculitis erythema nodosum eyes uveitis retinal vasculitis gastrointestinal diarrhea hemorrhage perforation pain vascular venous arterial thrombosis aneurysm neurological kinds especially meningo encephalitis articular arthralgia arthritis ankylosing spondylitis pathergy test positive patients india china data extracted five nationwide surveys largest case series conference reports pubmed search expert commentary diagnosis clinical classification diagnosis criteria may help best criteria international criteria behcet disease icbd multisystem disease progressing attacks remissions attack may resemble preceding may different duration severity systems involved
efficient parallel algorithm caputo fractional reaction diffusion equation implicit finite difference method proposed paper parallel algorithm consists parallel solver linear tridiagonal equations parallel vector arithmetic operations parallel solver order solve linear tridiagonal equations efficiently new tridiagonal reduced system developed elimination method experimental results show parallel algorithm good agreement analytic solution parallel implementation parallel processes two eight core intel xeon cpus times faster serial one single xeon core
large number individuals experience mental health disorders cognitive behavioral therapy cbt emerging standard practice reduction psychiatric symptoms including stress anger anxiety depression however cbt associated significant patient dropout lacks means provide objective data regarding patient experience symptoms sessions emerging wearables mobile health mhealth applications represent approach may provide objective data patient provider cbt sessions describe development classifier real time physiological stress healthy population apply controlled clinical evaluation armed forces veterans undergoing cbt stress anger management using cardiovascular electrodermal inputs wearable device classifier able detect physiological stress non clinical sample accuracy greater small clinical sample patients used classifier associated mhealth application less likely discontinue therapy significantly improved measures stress anxiety anger compared controls undergoing cbt alone given large number individuals experience mental health disorders unmet need treatment especially developing nations mhealth approaches potential provide augment treatment low cost absence person care
elevated blood cholesterol associated increased risk colorectal cancer crc observational studies causality uncertain apply mendelian randomisation analysis examine potential causal relationship lipid traits crc risk used single nucleotide polymorphisms snps associated blood levels total cholesterol triglyceride low density lipoprotein ldl high density lipoprotein hdl instrumental variables calculated estimates risk factor crc using snp crc associations cases controls genetically predicted higher associated elevated risk crc odds ratios per unit increase confidence interval pooled ors ldl hdl respectively genetic risk score hydoxy methylglutaryl coenzyme reductase hmgcr mimic effects statin therapy associated reduced crc risk study supports causal relationship higher levels crc risk rationale implementing public health strategies reduce prevalence hyperlipidaemia new observational studies suggested association blood cholesterol levels colorectal cancer crc establish causality may influenced confounding factors authors used mendelian randomization relationship genetic risk scores lipid traits crc provide new evidence causal link results point hyperlipidaemia important target crc prevention population
dysfunctional memory seems key component diverse dementias neuropsychiatric disorders unfortunately effective treatment exists probably absence neural biomarkers accompanying diverse neurotransmission systems implicated memory including serotonin hydroxytryptamine multiple serotonergic pharmacological tools well characterized downstream signaling mammals species neural markers providing new insights memory functions dysfunctions serotonin mammal species multiple neural markers including receptors serotonin transporter volume transmission present brain areas involved memory memory amnesia forgetting modify serotonergic markers influence bidirectional evidence shows insights therapeutic targets diverse approaches support translatability using neural markers cerebral functions dysfunctions including memory formation amnesia instance hta receptors involved tau protein hyperphosphorylation alzheimer disease addition least hta receptors well serotonin transporter seem useful neural markers therapeutic targets hence available evidence supports notion several mechanisms cooperate achieve synaptic plasticity memory including changes number neurotransmitter receptors transporters considering memory key component dementias hence reversing reducing memory deficits might positively affect wolters kluwer health inc rights reserved
background stress related disorders involve systemic alterations including disruption intestinal microbial community given putative connections microbiota immunity neural function behaviour investigated potential microbe induced gut brain signalling modulate impact stress host behaviour immunoregulation methods male cbl mice treated orally days either lactobacillus rhamnosus vehicle subjected chronic social defeat assessed alterations behaviour immune cell phenotype rrna sequencing mass spectrometry employed analyse faecal microbial community metabolite profile results treatment decreased stress induced anxiety like behaviour prevented deficits social interaction conspecifics however alter development aggressor avoidance following social defeat microbial treatment attenuated stress related activation dendritic cells increasing regulatory cells furthermore modulated effect stress faecal metabolites neuroactive immunomodulatory properties exposure social defeat altered faecal microbial community composition reduced species richness diversity none prevented stress related microbiota disruptions persisted vehicle treated mice weeks following stressor cessation conclusions data demonstrate despite complexity gut microbiota exposure single microbial strain protect certain stress induced behaviours systemic immune alterations without preventing dysbiosis work supports microbe based interventions stress related disorders
background aim study describe clinical characteristics systemic therapies given cohort patients attending first time tertiary psoriasis outpatient clinic methods data extracted electronic database patients mostly eligible systemic therapies consecutively recorded based skin disease severity subjects classified three groups group mild psoriasis psoriasis area severity index pasi group mild moderate psoriasis mmp pasi results patients studied presented map msp affected psoriatic arthritis patients deemed eligible systemic treatment started systemic treatment monotherapy therapies administered follows cyclosporine methotrexate etancreept adalimumab ustckinumab acitretin golimumab one conclusions data show composite distribution patients eligible systemic therapy attending first time center traditional drugs frequently administered compared biological ones
eye injuries sustained sport comprise per cent injuries eye serious enough medical attention sought prevalence eye injuries sport easily assessed due lack authoritative participation rates studies report total numbers time period evidence proportion ocular injuries sport reviewed relative frequencies different sports compared qualitative manner sports greater numbers ocular injuries detailed common occupational injuries eye sports eye injuries considered preventable hierarchy action occupational risk detailed adapted use sports scenario available international regional national standards sports eye protection detailed provisions compared major function standards provide adequate protection hazard sport concerned detailed compared function energy transfer eye protection must introduce additional secondary hazards instance fracturing sharp fragments impact introduce features would deter wearing eye protection instance restricting field view impede playing sport provisions standards intended limit secondary hazards detailed compared need future work standards writing activities international standardization organization sports eye protection detailed
one challenges sustainability analysis development optimum selection sustainable materials meet project requirements sustainable design achieved project team adopt use strategic approach selecting materials although could complex task decision makers building information modeling bim offers designers ability assess different design alternatives conceptual stage project method integration modeling techniques bim used assess impacts design alternatives energy saving buildings life furthermore bim potential help designers select right type materials early design stage make vital decisions selecting materials sustainable impact building life cycle main purpose study propose methodology integrates bim decision making problem solving approaches entropy topsis order efficiently optimize selection sustainable building components conceptual design stage building projects therefore decision support system dss developed using multiple criteria decision making mcdm techniques aid design team decide select optimum type sustainable building components design families conceptual design proposed projects based three main criteria environmental factors economic factors cost efficiency social well attempt identify influence design variations whole building sustainable performance multi criteria procedure embedded dss relies numerical models simulate alternative situations well ranking alternatives select best ones based owners strategic preferences availability sustainable materials market set models included dss describes relationship sustainability criteria manufacturers sustainable materials interactions project team take place design sustainable building projects paper aims exposing feasibility using bim analysing life cycle costs sustainable buildings conceptual stage design alternatives suggested dss evaluated integrated environment joins bim concept life cycle cost lcc method analyze operational cost whole building actual building project used validate workability capability proposed methodology
terrestrial dayglow displays prominent emission features bands atmospheric band system region present analysis observations wavelength region recorded space shuttle arizona airglow experiment major conclusion dominant product energy transfer result corroborates previous laboratory studies moreover critical interpretation dayglow possible interference bands region single important component band overlaps band present background must accounted reveal bands altitudes emissions coincide finally exploit different collisional behavior two lowest vibrational levels outline remote sensing technique provides information atmospheric composition temperature space based observations atmospheric bands
retrospective chart review completed patients self identified lesbian gay bisexual seen program survivors torture june december almost experienced persecution due sexual orientation survivors torture circumstances disclosure sexual orientation took place country origin often traumatic several efforts made change sexual orientation often forced marriage sex relationships relationships often marred tragedy women likely forced move place place experience rape sexual assault threats whereas men likely persecuted people street presented symptoms depression anxiety providers need attuned potential traumatic histories fleeing persecution due sexual orientation medical social psychological legal implications
background aim study third ventricular colloid cysts tvcc defined population estimate incidence presenting features surgical treatment treatment related complications clinical surgical outcomes methods reprospective study consecutive primary surgeries tvcc performed oslo university hospital time period results estimated incidence rate tvcc per million mean age years male female ratio common presenting symptoms headache ataxia reduced level consciousness impaired vision surgical mortality gross total resection gtr achieved based intraoperative findings based postoperative imaging rate ofsurgery related complications statistically significant difference microsurgery endoscopic surgery respect surgery related complications grade resection time follow patients able care conclusions due risk acute neurological deterioration sudden death surgical treatment recommended patients symptomatic tvcc study shows surgical resection performed fairly low risk good long term outcome
objective examine general dental orthodontic utilization expenditures health insurance status public health insurance eligibility sociodemographic characteristics among children aged years using data methods nationally representative data medical expenditure panel survey provided data insurance status public health insurance eligibility visits dental providers general dental care orthodontic care results overall children reported annual dental office based visit general nonorthodontic dental care fewer hispanic non latino black children received dental care compared non hispanic whites asians children living families lowest income also least likely visit compared children highest income families among children eligible public coverage medicaid eligible children lowest percentage preventive dental visits socioeconomic racial ethnic disparities use expenditures orthodontic care much greater general preventive dental care average expenditures orthodontic care paid pocket families conclusions findings provide baseline assessment examining trends future especially coverage patterns children may change affordable care act implemented future state child health insurance program remains uncertain beyond
incretins glucagon like peptide glp glucose dependent insulinotropic polypeptide gip growth factors shown neuroprotective effects animal models parkinson alzheimer disease addition glp mimetic exendin shown protective effects clinical trial parkinson disease patients glp analogues currently market treatments type diabetes previously showed novel dual agonist jci effective methyl phenyl tetrahydropyridine mptp mouse model demonstrate neuroprotective ohda brain lesion rat model treating rats weeks nmol daily motor activity tested rotarod open field much improved amphetamine apomorphine circling behaviour tests ohda induced impairments much reduced treatment number positive dopaminergic neurons substantia nigra decreased ohda lesion increased treatment dopamine levels basal ganglia reduced ohda lesion increased western blot analysis levels growth factor gdnf pakt creb cell signaling enhanced autophagy marker beclinl also activated drug results demonstrate dual glp gip receptor agonists show promise novel treatment elsevier ltd rights reserved
aim children highest rates food related allergic reactions children outgrow allergies including cow milk eggs five years age allergies peanuts seafood continue adulthood school setting poses high risk environment allergen exposure aim present study examine availability drivers communication school food allergy awareness management policies guidelines one australian education jurisdiction methods cross sectional study comprising online survey principals school allergy awareness conducted public catholic independent primary high schools australian education jurisdiction august november results sixty three per cent schools responding survey reported using food allergy management guidelines average students per school reported food allergy schools reported students least one food allergy parents government policy identified primary drivers food allergy guideline implementation third schools provided anaphylaxis training annually communication food allergy management limited school websites either providing access policies guidelines providing food allergy statement conclusions detailed awareness management guidelines integral schools adequately manage food induced allergic reactions including anaphylaxis school environment enable national government support legislation policy needed ensure consistent date policed approach food allergy management australian education sector
several issues related practical synthesis ternary sequences specified spectra addressed paper specifically sequences harmonic multiples two three suppressed studied given relevance testing characterizing nonlinear systems particular effect nonuniform digital analog converter dac levels spectral properties generated signal analyzed analytically shown dac nonuniform levels result degraded harmonic suppression performance moreover new approach proposed designing ternary sequences flexible adapted suit different requirements resulting sequences denoted randomized constrained sequences characterized theoretically deriving analytical expression power spectral density furthermore extensively compared three synthesis approaches proposed literature approach validated numerical simulations experimental results showing potential achieve harmonic suppression performance approximately
paper presents fifteen distinct practical realizations dual second generation current conveyor dxccii using commercially available integrated circuits detailed comparisons results presented verify utility proposed realizations catalog proposed realizations first attempt expected useful testing newly developed circuits based dual second generation current conveyor first fourteen proposed realizations uses four ics one three based implementation given making total count fifteen additional features also explored enhance versatility dxccii paper presents novel compact quadrature oscillator verify applicability proposed realizations single resistance control frequency oscillation also demonstrated employing new gain variable dxccii experimental results also included along simulation results validate proposed theory practical significance
irritability symptom disorders dsm included mood disorders addictive disorders personality disorders american psychiatric association however term irritability defined measured inconsistently scholarly literature article reviewed scholarly definitions irritability item content irritability measures components definitions items measuring irritability divided three categories causes experience consequences also reviewed potential causes biomarkers irritability found much overlap definitions measures irritability related constructs anger aggression consequently validity research irritability needs questioned including role irritability psychopathology presence irritability symptom disorder research irritability role behavioral disorders needs repeated well defined measures developed proposed precise definition irritability clearly differentiates related constructs suggested items measuring irritability also provided elsevier ltd rights reserved
paper two types tensor product finite macro elements contrasted former well known lagrange type latter bezier bernstein type elements although different mathematical origin seemingly irrelevant based complete polynomials thus sharing functional space classes therefore theoretical point view anticipated lead numerically identical results static dynamic analysis types elements details provided concerning main computer programming steps selective parts typical matlab code presented numerical application includes static laplace poisson eigenvalue acoustics transient heat conduction problems rectangular circular elliptic shapes treated single macroelement agreement theory six examples results obtained using bezier lagrange polynomials found identical exceptional accuracy elsevier ltd rights reserved
increased knowledge dna binding proteins would enhance understanding protein functions cellular biological processes handle explosive growth protein sequence data researchers developed machine learning based methods quickly accurately predict dna binding proteins recent years predictive accuracy machine learning based predictors significantly advanced predictive performance remains unsatisfactory paper establish novel predictor named local dpp combines local pse pssm pseudo position specific scoring matrix features random forest classifier proposed features efficiently capture local conservation information together sequence order information evolutionary profiles pssms evaluate compare local dpp predictor state art predictors two stringent benchmark datasets one jackknife test independent test proposed local dpp significantly improved accuracy existing predictors jackknife independent tests respectively demonstrates efficacy effectiveness local dpp predicting dna binding proteins elsevier inc rights reserved
radio telescope system widely used investigating astronomical objects requires good pointing system fact receives remarkably weak signal space new development increase parabolic dish size operating frequency made however development caused position control stringent paper employ pid controller introduces fuzzy logic controller purpose different type membership function tested order choose best output result performance best type compared pid controller controllers designed simulink matlab environment proposed fuzzy controller able attenuate overshoot pid overshoot speed position loop hence fuzzy logic controller greater performance pid controller
repeated airway inflammation unremitting remodeling provoke irreversible pulmonary dysfunction resistance current drugs patients chronic bronchial asthma interleukin play important role airway inflammation remodeling asthma aimed investigate whether inhibiting effectively regulate allergen induced airway inflammation remodeling mice mice asthma induced chronic exposure ovalbumin ova given soluble receptor alpha sil soluble receptor sil protein alone combination neutralize bioactivity relevant airway inflammation remodeling experiments performed found blockade sil sil effective either agent alone decreasing inflammatory cell infiltration airway hyperresponsiveness ahr airway remodeling including mucus production extracellular collagen deposition smooth muscle cell hyperplasia angiogenesis mice exposed ova results suggest combined inhibition may provide novel therapeutic strategy asthma especially patients resistant current treatments published elsevier
abundant aspects big data technology increasing due new methods fetching data diverse needs meteorological data also source big data terms volume variety veracity velocity includes structured unstructured hybrid forms paper aims apply hadoop architecture mapreduce algorithm meteorological big data also describes difficult situations dealing complex meteorological data present computer systems replace distributed computing automatic text classification used divide text predefined classes help individuals utilize information effective method paper gives idea implement meteorological text classification big data approach traditional text classification requires high cost domain knowledge low classification efficiency satisfy requirement large documents processing distributed parallel method well developed solve problem large number documents classification finally paper describes big data applications meteorological big data combined agriculture transportation power grid industries illustrates analyze tourism industry meteorological tourism big data platform
known objectivespsychopharmacologic therapy far focused ameliorating disruptive behaviours improve patient function quality life due complicated neurobiological aetiology autism spectrum disorder asd traditional pharmacist intervention may insufficient initiate optimal care vulnerable population evaluate impact providing specialty psychiatry pharmacist intervention identifying resolving drug related problems drps among children asd associated disruptive behaviours methodsan eight week long prospective randomized open label study conducted children years age asd showing disruptive behaviours included randomly assigned intervention control group patients intervention group received pharmacist interventions delivered pharmacist control group cared hospital pharmacist primary outcome number patients resolved least one drp end study secondary outcome compare mean aberrant behavior checklist irritability abc scores two groups resultstwenty five patients randomly assigned either intervention control group week total number patients resolved least one drp intervention group control group respectively improper drug selection medication non adherence subtherapeutic dosage common drps mean abc scores improved intervention group control group new conclusionto best knowledge first study demonstrated pharmacist intervention effective strategy resolve drps patient asd reduction common drps mostly resulted pharmacist interventions including selection antipsychotic agent adjustment dosage based abc scores provision individualized drug counselling reducing drps led improvement disruptive behaviour addition multidisciplinary team develop drug therapy protocols promote role pharmacists setting
biometrics deals authenticating person identity based physiological behavioral characteristics visual cryptography promising information security technique allows secret sharing images without cryptographic computations various existing schemes introduced securing raw biometric data template database using technique complexity encryption plays vital role security improvement order overwhelm limitations secure authentication management polar iris templates presented using technique collaborative splitting pixels directions presented paper done order improve security first input image segmented using canny edge detection hough transform subsequently normalization module transformed iris texture cartesian polar coordinates polar iris image separated two shares namely share share using technique accomplish security existing methods discrete wavelet transform dwt advanced encryption standard aes shifting techniques introduced termed transform based aes taes receiving encrypted image feature extraction carried multi scale local binary pattern mlbp share images stored user database whereas share images stored server database classifier employed recognize retrieve share user database basis features finally reconstruction performed recognized share share images using inverse process taes experimental results exhibit better peak signal noise ratio psnr mean square error mse normalized correlation false acceptance rate far false rejection rate frr equal error rate eer existing methods
pay attention influenced reward learning previously reward associated stimuli difficult ignore automatically drawing attention even know longer beneficial recent research suggested value dependent attentional biases affect perception biasing individual act way pursue attended stimulus review evidence argue direct link attentional biases shifts action related priorities given link abnormal otherwise inappropriate rewardrelated attentional biases hypothesized contribute undesired habits poor economic choices
despite well established sex difference prevalence many childhood adolescent psychopathological conditions integrative metatheory sex differences psychopathology exists review attempts provide metatheoretical framework guide empirical examination sex differences prevalence childhood onset externalizing adolescent onset internalizing disorders based sexual selection evolutionary theory sexual selection theory suggests important sex differences markers mechanisms etiology developmental timing risk resilience relevant psychopathology namely sexual selection theory hypothesizes disinhibition sensation seeking may important proximate risk markers childhood onset externalizing disorders males theory suggests male biased markers may product higher exposure prenatal testosterone makes susceptible prenatal stressors downstream effects dopaminergic neurotransmission especially genetic alleles associated lower dopaminergic function contrast sexual selection theory hypothesizes negative emotionality empathy cognitive rumination may important proximate risk markers adolescent onset internalizing disorders females theory suggests markers propagated rapidly rising levels estradiol puberty interact cortisol oxytocin hormones exert downstream effects serotonergic system way increase females sensitivity interpersonal stressors particularly puberty especially lower functional serotonergic activity metatheory help integrate prior ideas sex differences also generate new predictions sex differences markers etiology mechanisms developmental timing common forms psychopathology
narcissists individuals whose personality exudes excessive self love inflated views self date clear understanding excessive love self related performance present study examines whether narcissists inflated views performance substantiated objective accounting performance results show individuals score high narcissism evaluate performances self assessment correlated objective indicators indeed away magic mirror wall narcissists greatest performers elsevier ltd rights reserved
environmental governance systems greater pressure adapt cope increased social ecological uncertainty stressors like climate change review principles social cognition decision making shape constrain environmental governance systems adapt focus primarily interplay key decision makers society legal systems argue adaptive governance must overcome three cooperative dilemmas facilitate adaptation encouraging collaborative problem solving garnering social acceptance commitment cultivating culture trust tolerance change uncertainty however governance systems must cope biases people decision making cloud judgment create conflict systems must also satisfy people fundamental needs self determination fairness security ensuring changes environmental governance perceived legitimate trustworthy acceptable discuss implications principles common governance solutions public participation enforcement conclude methodological recommendations outline scholars investigate social cognitive principles involved cases adaptive governance
cement production process energy intensive terms thermal energy firing kiln drying carbonation electrical energy driving numerous drives within process line average specific power consumption case study plant kwh ton cement average peak demand high cost electric power usd kwh results high cost production significantly lowers company profit margin limits competitive advantage generation electrical power waste heat recovery would reduce electricity power bill partially substituting power procured national grid research evaluated potential plant generating electrical power hot waste gases vented atmosphere found plant potential generate mwh electrical power results net potential generate mwh electrical power factoring auxiliary power consumption waste heat recovery plant system ultimately gave reduction electricity power bill case study plant paper recommends installation steam rankine cycle power generating plant work authors designed steam boilers waste heat recovery plant conversion thermal energy electrical energy selected commercial steam turbine evaluated economic feasibility established designed plant would simple payback period years
investigated risk stroke associated renal dysfunction impact warfarin therapies chinese patients nonvalvular atrial fibrillation nvaf information collected age sex height weight type atrial fibrillation serum creatinine within previous months together variables needed calculate chads score patients taking warfarin reasons recorded three thousand seventeen eligible patients nvaf mean standard deviation age years chinese hospitals included may october mean chads score male high risk stroke chads score warfarin patients moderate severe renal impairment estimated glomerular filtration rate min adjustment chads score renal dysfunction remained moderately significantly associated risk stroke tia odds ratio confidence interval however significant difference anticoagulant usage patients without impaired renal dysfunction common anticoagulant concerns low proportion patients regular international normalized ratio monitoring risk bleeding renal impairment common independently associated risk cerebrovascular embolism chinese patients nvaf independently related underuse anticoagulant treatment
prenatal development sacral region spinal cord goat studied using foetuses various age groups region prominent dorsal horn also presented reticular formation sacral nucleus stilling prominent substantia gelatinosa seen first sacral segment first second segments showed lateral horn wide ventral horn fourth segment presented dispersed nuclear aggregations decreased white matter central canal narrow first sacral segment elongated second segment wider fourth segment white matter sacral segments exhibited undivided dorsal funiculus medial longitudinal fasciculus second month onwards tracts bordering ventral median fissure spinocerebellar tracts seen fourth month onwards
dielectric elastomers des respond applied electric voltage surprisingly large deformation showing promising capability generate actuation mimicking natural muscles theoretical foundation mechanics des crucial importance designing based structures devices review survey recent theoretical numerical efforts exploring several aspects electroactive materials emphases governing equations electromechanical coupling constitutive laws viscoelastic behaviors electromechanical instability well actuation applications overview analytical models provided based representative approach non equilibrium thermodynamics computational analyses required generalized situations irregular shape complex configuration time dependent deformation theoretical efforts devoted enhancing working limits actuators avoiding electromechanical instability well electric breakdown pre strains shown effectively avoid two failure modes studies lay solid foundation facilitate use materials structures devices wide range applications biomedical devices adaptive systems robotics energy harvesting etc
video tracking main field computer vision tld algorithm plays key role long term tracking however original tld ignores color features patch detection tracks common points grid tracking accuracy limited paper presents novel tld algorithm harris corner color moment overcome drawback instead tracking common points screen important points utilizing harris corner reject half patches points better able show object textural features addition color moment classifier replaces patch variance reduce errors detection classifier compares mine dimensional color moment vectors keep tld stable speed experiment proved tld tracks reliable position higher ability without affecting speed
background purposeportugal identified one countries high prevalence lrrk considered frequent known cause familial sporadic parkinson disease aim study evaluate prevalence portugal using door door methodology methodsa cross sectional study conducted portuguese community dwelling population elderly people living community aged years resident mainland portugal two phases questionnaire applied screen potential cases screened cases evaluated expert confirm diagnosis resultsthe adjusted prevalence portuguese community dwelling population aged years estimated total number cases portuguese population inhabitants conclusionsthe results study show geographical region high frequency causal mutation automatically imply high prevalence patients
ambient intelligence ami environment electronic devices comprise internet things iot network work together seamlessly provide wide variety applications intelligent services users computer assisted pronunciation training capt widely used application traditional internet environment corrects user pronunciation promising service transition ami environment however migration capt ami environment challenging due high computational requirements odds low computational capacity iot members paper propose smartphone assisted pronunciation learning technique based lightweight word recommendation method exploits built functions supported iot members computationally moderate word selection method experimental evaluation proposed method demonstrates user pronunciation significantly improved without incurring unacceptable computational costs smartphone platform
automatic steering systems large tractors designed hydraulic systems run either constant flow constant pressure designs limited adaptability applicability moreover control valves unload neutral position eventually lead serious hydraulic leakage long operation periods response problems noted multifunctional automatic hydraulic steering circuit presented system design composed way position proportional directional valve two pilot controlled check valves pressure compensated directional valve pressure compensated flow regulator valve load shuttle valve check valve among components adaptable open center systems constant flow supply closed center systems load feedback design maintains lowest pressure load feedback stays neutral position unloading thus meeting requirements steering steering controller based proportional integral derivative pid running microcontroller unit master control chip experimental platform developed establish basic characteristics system subject stepwise inputs sinusoidal tracking test results show system design demonstrates excellent control accuracy fast response negligible leak long operation periods
relationship orientation small scale ionospheric irregularity anisotropy plane perpendicular geomagnetic field direction plasma convection region investigated crossfield anisotropy irregularities obtained fitting theoretical expectations amplitude scintillations satellite radio signals actual measurements information plasma convection provided superdarn radars joint satellite radar observations auroral zone polar cap considered shown irregularity cross field anisotropy agrees quite well direction plasma convection best agreement events quasi stationary convection patterns
renewable energy expected major part future energy presently intermittence fluctuation lead limitation penetration reversible solid oxide fuel cell rsofc energy storage device effectively store renewable energy build bidirectional connection natural gas paper energy storage strategy designed improve penetration dynamic operation stability distributed system coupling wind generators internal combustion engine rsofc lithium ion batteries compromising relative deviation power supply demand penetration system efficiency capacity requirement strategy maximum wind power output directly supplied users stored combination battery reversible solid oxide fuel cell optimal distributed system case penetration reached system efficiency reached maximum relative deviation power supply demand also lower significantly superior wind curtailment case elsevier rights reserved
alcohol dependence characterized corticostriatal impairments individual brain areas striatum yet however complex brain network topology association disease progression unknown applied graph theory resting state functional magnetic resonance imaging fmri examine weighted global efficiency local clustering coefficient degree eigenvector centrality network topology functional role striatumin patients compared matched healthy controls hcs association dependence characteristics graph analyses performed based pearson correlations fmri time series correcting age gender head motion found significant group differences patients hcs network topology notably within patient group hcs whole brain network showed reduced average cluster coefficient severe alcohol use whereas longer duration within patient group associated global decrease efficiency degree clustering coefficient additionally within four priori chosen bilateral striatal nodes alcohol use severity associated lower clustering coefficient left caudate longer duration associated reduced clustering coefficient caudate putamen reduced degree bilateral caudate increased eigenvector centrality left posterior putamen especially changes global network topology clustering coefficient anterior striatum remained strikingly robust exploratory variations network weight results show adverse effects overall network integration possibly striatal efficiency putatively contributing increasing behavioral impairments seen chronically addicted patients
utilized sociocultural lens qualitative approach examine causal attributions caregiving approaches parents children intellectual disability mid sized indian city sixteen mothers three fathers participated semi structured interview findings elucidate participants active processing cause child intellectual disability seemed simultaneously draw upon religious biological situational factors construct explanation far caregiving approaches parents reported moving away gradually mainstream medicine alternative medicine physiotherapy regular education settings special schools themes highlight role sociocultural factors also cross cultural similarities parental causal attributions caregiving approach findings discussed context implications social work practice policy india
water distribution systems wdss construction operation disposal processes contribute undesirable greenhouse gas ghg emissions ghg concentration atmosphere strongly associated global warming climate change order meet consequent challenge limiting ghg emissions problem wds design formulated multi objective optimisation problem three objectives follows minimisation total design cost maximisation wds resilience minimisation ghgs emissions addition frequently considered conventional design intervention options new pipes pipe duplication replacement addition pumps tanks etc various water demand management interventions water efficient appliances domestic rainwater harvesting systems considered number different rainwater tank sizes water saving appliances provided different parts households evaluated methodology applied new york tunnels anytown network problems output non dominated sorting genetic algorithm nsga optimisation process pareto front containing optimal solutions traded terms three objectives analysed results obtained demonstrate using demand management technologies design wdss lead similar cost resilience ghg emissions cost savings pumped wds cost savings ghg emission reduction relatively significant demand management technologies led cost effective resilient climate change mitigating solutions compared conventional design
background although prevalence mental illness among young people asthma known twice rate wider population none asthma apps reported acknowledged attempted include psychological support features perhaps user involvement development asthma apps scarce user involvement facilitated participatory design methods begin address issues contributing insights understanding psychological experience associated asthma technology might improve quality life objective goal participatory user research study explore experience needs ideas young people asthma allowing define requirements asthma app would engaging effective improving well methods young people aged years doctor diagnosed asthma invited participate participatory workshop complete workbook designed elicit thoughts ideas living asthma technology use design app participants generated number artifacts including collages concept maps paper prototypes designed reify ideas tacit knowledge experience results total participants mean age years female representing range inadequately well controlled asthma completed workbook also took part workshop four workshops held total resulting participant generated artifacts theoretical thematic analysis resulted set personal needs feature ideas app characteristics considered relevant young people asthma support app data revealed psychological factors anxiety impediments autonomy competence relatedness consistent self determination theory sdt considered major influences quality life young people asthma furthermore incorporation features pertaining psychological experience particularly valued participants conclusions addition practical features asthma management app young people asthma include support mental health factors associated lived experience anxiety lack autonomy social disconnectedness show support factors translated design features app asthma addition informing development asthma support technologies young people findings could implications technologies designed support people chronic illness generally
previous work shown compared passive perceivers view preselected information target persons active perceivers less confident impressions show increased confidence increased amounts information like targets less authors explain findings postulating perceivers without control amount information receive motivated form impressions earlier altering information processing strategies study predicted found content active perceivers control content amount information show positive relationship confidence amount information passive perceivers well reading time patterns level liking study used clearly valenced target stimuli found support hypothesis passive perceivers form extreme early impressions leading greater liking early information positive less liking negative
purpose aspergillosis central nervous system rare however recent increases use immunosuppressive agents antibiotics incidence increasing evaluated demographics clinical manifestations laboratory findings diagnosis underlying conditions treatment regimens outcomes patients cerebral aspergillosis methods retrospectively reviewed data eight patients hospitalized chinese general hospital january september results common clinical manifestations included headache cranial nerve involvement four patients underwent biopsy pathologically diagnosed aspergillus hyphae one patient proved aspergillus infection via autopsy one patient positive cerebrospinal fluid fungal cultures lesion locations cavernous sinus frontal lobe temporosphenoid lobe cerebellum end follow three patients cured five patients died mortality rate conclusions patients significant immunosuppression related conditions study aspergillus spp infect central nervous system several pathways atypical clinical manifestation use local tissue puncture surgery invasive means obtain diseased tissue containing higher levels aspergillus followed culture histological examination contribute early diagnosis timely therapeutic intervention prognosis poor early adequate use antifungal drugs high transfer across blood brain barrier radical surgery remove lesions improve survival rate
objective chronic pain recognized neural disease results maladaptive functional structural transformation process occurring time chronic phase pain symptom also disease entity therefore pain must properly addressed many patients still report unsatisfactory pain control despite going treatment selection therapy taking account pathophysiological mechanisms pain right timing result successful analgesic outcome review present functional structural modifications leading chronification pain focusing role tapentadol setting materials methods inclusion review research studies retrieved via keyword based query multiple databases medline embase cochrane search last updated november limitations applied results functional structural abnormalities nervous system associated pain chronification reported several conditions including osteoarthritis chronic back pain chronic pelvic pain fibromyalgia correct identification treatment pain recurrent progressive stage crucial prevent chronification related changes neural structures among analgesic drugs tapentadol dual mechanism action opioid agonist noradrenaline reuptake blocker recently resulted active pain control central spinal level conclusions tapentadol represents suitable candidate patients early progressive stage pain developed neuroplasticity modification pain pathways availability different doses tapentadol may help clinicians tailor treatment based individual need patient aim enhance therapeutic appropriateness treatment musculoskeletal neuropathic pain
estimation value engineering project tourist towns usually challenging controversial study attempt made evaluate economic value debris flow control engineering tourist towns integrating welfare disaster economics total value debris flow prevention control engineering tourist towns vdfe includes investment cost disaster mitigation benefit dmb loss brand value lbv dmb assessed cost benefit method lbv estimated incorporating brand equity cost benefit methods engineering debris flow control hongchun gully southwest china built protect yingxiu tourist town assessed example engineering million rmb however vdfe reaches high million rmb lbv million rmb input output ratio thus lbv neglected case vdfe estimation process developed tourism one town city greater lbv higher vdfe
study identifies informational factors judgment processes involved making two case management decisions within consolidated long term care program evaluating risk nursing home placement choosing care plan multidisciplinary case management team formulated decisions hypothetical clients described vignettes team used information client condition program available resources judging risk institutionalization client related information selecting care plan
study evaluates long term performance two types geotextiles used years drainage trenches stabilize slopes french alps flow rate analysis trench enabled estimating average permittivity trench scale exhuming geotextiles hydraulic mechanical properties assessed hydraulic tests performed geotextiles alone gave permittivities greater gradient ratio tests performed undisturbed soil geotextile drainage specimens gave results order aged specimens examined using scanning electron microscopy quantifying overall performance geotextile filter complicated brittleness calcite crust subsequent difficulty characterizing undisturbed interfaces various possible explanatory mechanisms involved deterioration trench performance reviewed filter cake blinding internal clogging downstream chemical clogging existing analytical models used order predict loss hydraulic performance due clogging mechanisms comparing measured permittivities calculated permittivities demonstrated chemical clogging due calcite precipitation downstream face geotextiles probably preponderant mechanism responsible poorer performance geotextile filters trench scale elsevier ltd rights reserved
low fermentable oligosaccharides disaccharides monosaccharides polyols fodmap diet good evidence use treatment patients irritable bowel syndrome importantly patients encouraged remain strict low fodmap diet long term many patients maintain symptom improvement relaxed moderate fodmap restriction challenge phase crucial assist patients identifying specific dietary triggers reduce level dietary restriction required increase prebiotic intake limited evidence available guide best practice practice beneficial outcomes seen strategic food reintroductions set practical recommendations based clinical experience dietitians tailor challenge process individual patient needs food challenges aim improve dietary variety nutritional adequacy considering specific food preferences usual dietary habits identifying fodmap subgroups well tolerated helpful allowing reintroduction moderate high fodmap foods back diet without symptom induction fodmap subtypes less well tolerated may also reintroduced dosage frequency consumption need individualized additional challenges face dietitians include consideration patients multiple dietary restrictions vegetarians patients diabetes simultaneously following low fodmap diet ensuring nutritional adequacy essential outcome challenge process aims find balance good symptom control expansion diet
compared earlier programming data structure experiences students might perspective changes computers programming introducing theoretical computer science picture underlying computational models need addressed mathematical tools employed understand quality criteria theoretical computer science focus shifts proving several years tried make perspective transition smoother students third year mandatory algorithms data structures computational complexity course concepts receiving extra attention work completeness one central concepts computer science dynamic programming algorithm construction method powerful somewhat unintuitive students major difficulties attribute completeness tasks look similar different purpose algorithm construction exercises students immediately see usefulness concept hence motivation could one issue one line attacking completeness emphasize algorithmic aspects using typical tools teaching algorithms potential difficulties associated dynamic programming method based known difficult concept recursion many ingredients dynamic programming solution problem dynamic programming completeness invented several new activities structured teaching differently forcing students think adopt standpoint practice concepts programming assignments student surveys show activities appreciated students evaluations indicate positive effects learning believe activities could useful similar course approach improving course action research evaluation done using course surveys self efficacy surveys rubrics like grading protocols grades also interviewed teaching assistants experiences
abcs sleeping mnemonic developed serve organizing framework common pediatric sleep recommendations mnemonic stands age appropriate bedtimes wake times consistency schedules routines location exercise diet electronics bedroom bed positivity independence falling asleep needs child met day equal great sleep review examines empirical evidence behind practices recommendations captured abcs sleeping mnemonic children aged search conducted key electronic databases pubmed psycinfo cinahl embase identify english articles included concepts sleep insomnia bedtime articles eligible inclusion coded extract key details findings regarding relations sleep practices identified abcs sleeping mnemonic sleep outcomes findings provided preliminary support many recommendations commonly made families regarding healthy sleep practices however robust investigations needed better understand causal contributions healthy sleep practices onset maintenance children sleep problems elsevier ltd rights reserved
purpose medicare beneficiary spending patterns reflect hospital referral regions physicians train whether holds true smaller areas quality uncertain study assesses whether cost quality imprinting detected within hospital service areas hsas percent teaching hospital whether sponsoring institution characteristics associated methods conducted secondary multi level multivariable analysis medicare claims american medical association masterfile data random nationally representative sample family physicians general internists completed residency medicare patients physicians providing care beneficiaries practice training locations matched dartmouth atlas hsas categorized low average high cost spending groups practice training hsas assessed differences diabetes quality measures institutional characteristics included training volume percentage graduates rural practice primary care results unadjusted annual per beneficiary spending difference physicians trained high low cost hsas difference remained significant controlling patient physician characteristics significant relationship found diabetes quality measures general internists significantly likely family physicians train high cost hsas institutions graduates rural practice primary care produced lower spending physicians conclusions imprint training spending patterns physicians strong enduring without discernible quality effects along identified institutional features supports measures policy options improved graduate medical education outcomes
practice self directed learning important adult students allows learn effectively juggling work family commitments study set examine self directed learning characteristics present adult students study process case university relationship adult students perceived competence level self directed learning academic performance also investigated study adult students case university participated survey included likert type open ended response items eleven indicators self directed learning conceptualised quantified indicators included goal setting time management procrastination management assignment preparation exam preparation note taking capability research capability seminar class readiness technical readiness online class readiness stress management findings showed adult students perceived level competence self directed learning indicators direct indirect effect academic performance based findings case university conceptualised new initiatives provision support terms self directed learning help adult students well studies
study question diagnosis common diseases menopause influence age natural menopause anm onset summary answer polycystic ovary syndrome pcos depression observed delay menopause known already observed women undergo early menopause experience higher burden health problems related metabolic syndromes heart disease depression whether anm influenced common adult diseases studied extensively study design size duration women attending mammography screening clinical mammography four hospitals sweden invited participate karolinska mammography project risk prediction breast cancer karma study january march women recruited information baseline questionnaire filled upon enrollment used cross sectional analysis predictors anm onset participants materials setting methods limited analyses women complete data anm covariates follow time birth menopause censoring least years premenopausal diagnoses depression anorexia bulimia pcos ovarian cyst heart failure myocardial infarction angina pectoris stroke preeclampsia diabetes hypertension hyperlipidemia examined time dependent variables multivariable cox regression analyses adjusting reproductive factors age menarche menstrual cycle regularity adult life number children premenopausal oral contraceptive use risk factors common diseases education physical activity years information time questionnaire including bmi ever smoking alcohol consumption main results role chance women pcos depression independently associated later menopause hazard ratio respectively compared women histories associations remained significant subset women never received gynecological surgery hormone treatment respectively none diseases examined significantly associated anm limitations reasons caution information questionnaire self reported making recall possible unlikely bias different strata different factors considered misclassification could also occurred cases diagnoses common diseases close age last follow addition observational studies establish associations identified represent cause effect relationships wider implications findings study first examining multiple common diseases simultaneously determinants anm contrary previous reports find significant accelerating effect hypertension cardiovascular disease diabetes anm
last climatic years recorded recrudescence risk phenomena especially floods droughts reason acute shortage water presently felt even mountainous areas hydrological data recorded gauges distributed middle lowers sectors basin suha river basin includes large number inhabitants attracted time ago mining exploitations closing ostra mine led decrease population thus water demands higher higher underground resources used minimum discharge basin extremely low comparison reality mountain catchments stulpicani gauge mean minimum discharge recorded situation due first rapid infiltration water permeable deposits sands gravels boulders increase water demands probable comfort dwellings improved raising number baths showers greenhouses vegetables growing guest houses pools etc order preserve water resources area imposed keeping present forested surfaces adequate control tailings dumps avoid underground surface water pollution due practices like toilets lacking septic tanks gathering manure isolated platforms conservation present water quality especially underground one imperious
study investigated effects metaconceptually enhanced simulation based inquiry learning eighth grade students conceptual change science development science epistemic beliefs two experimental groups studied topics motion force using computer simulations different simulation guides one enhanced metaconceptual scaffolding findings led following conclusions metaconceptual scaffolding enhanced simulation based learning significantly reducing science misconceptions effective changing students mental models consisted multiple interrelated key concepts students beliefs speed learning construction knowledge strong predictors conceptual change learning outcomes epistemologically mature students benefit metaconceptual interventions less mature beliefs interventions needed promote development students science epistemic beliefs inquiry learning
long term use novel antipsoriatic systemic biotechnological drugs may increase susceptibility opportunistic infections several cases visceral leishmaniasis reported immunosuppressed individuals including treated tumour necrosis factor alpha tnf alpha blocking agents simultaneous occurrence cutaneous visceral involvement rarely recorded medical literature herein describe case mucosal leishmaniasis occurring farmer living endemic region treated golimumab psoriatic arthritis highlights importance recognizing cutaneous lesions first indicator possible underlying kala azar disease
novel adaptive weight online sequential extreme learning machine awos elm proposed predicting time series problems based online sequential extreme learning machine elm paper real world online applications sequentially coming data chunk usually possesses varying confidence coefficients data chunk low confidence coefficient tends mislead subsequent training process proposed awos elm improve training process accessing confidence coefficient adaptively determining training weight accordingly experiments six time series prediction data sets verified awos elm algorithm performs better generalization performance stability prediction ability elm algorithm addition real world mechanical system identification problem considered test feasibility efficacy awos elm algorithm
disrupting circadian rhythms cause health problems sleep disorders memory disorders obesity finding suitable external stimulation synchronize model desired phase biologically significant issue phase control circadian rhythms drosophila considered control engineering viewpoint paper parameters model known use feedback linearization design tracking controller phase control however practice parameters uncertainties always exist deal problem slide mode controller proposed phase tracking control circadian rhythms simulation results show effectiveness proposed method
multiple exp function method new approach obtain multiple wave solutions nonlinear partial differential equations nlpdes method one obtain multi soliton solutions nlpdes hence paper using symbolic computation apply multiple exp function method construct exact multiple wave solutions dimensional soliton equation based application obtain mobile single wave double wave multi wave solutions equation addition employ straightforward algebraic hirota bilinearization method construct multi soliton solutions nlpdes reveal remarkable property soliton soliton collision approach investigate one two soliton solutions dimensional soliton equation using hirota method explore particle like behavior elastic interaction solitons potential application optical communication systems switching devices
software product line spl development new approach software engineering aims development whole range products however long spl useful many challenges regarding use approach one main problems hinders adoption software product line spl complexity regarding product management context remark scoping problem one existent ways deal scoping product portfolio scoping pps pps aims define products developed well key features general approach driven marketing aspects like cost product customer satisfaction defining product portfolio using many different available aspects hard problem work presents improved hybrid approach solve feature model selection problem aiming supporting product portfolio scoping proposal based hybrid approach dependent particular algorithm technology evaluated usefulness scalability approach using one real spl argouml spl synthetic spls per evaluation results approach useful practitioner perspective scalable elsevier rights reserved
course past years since first iron steel based bridge constructed japan become one advanced countries construction steel structures various innovative elegant steel structures constructed past world longest suspension bridge called akashi kaikyo bridge advances steel structures attributed significant extent development high performance steels materials developed japan characterized three types versatilities strength functional sectional examples materials include fairly high low strength steels high bridge performance steel seismic resistant steel fire resistant steel size flexible shaped beam japan steel material innovations enabled progress steel structures leap forward turn challenging new structures gave birth advancements steel materials paper advancements steel structures materials reviewed focusing largely steel materials contributions construction steel structures addition light recently developed innovative steels strength increasing potential advancements steel materials suggested future innovations steel structures
advent direct acting antivirals daa oral hcv treatment regimens exists great opportunity provide hcv treatment people inject drugs pwid enrolled opioid treatment program retrospective study conducted context routine clinical care explores outcomes hcv treatment daas pwid enrolled otp study showed treatment outcomes among first patients treated daas nearly equivalent patients general population ninety eight percent patients completing treatment obtained sustained virologic response patients lost follow ninety nine percent patients adhered hcv treatment ongoing drug use occurred patients however alter hcv treatment outcomes treating hcv infection daas pwid onsite otp feasible elsevier inc rights reserved
paper presents high performance current differencing transconductance amplifier cdta recently reported active element especially suitable analog signal processing applications high linearity cmos configuration cdta made high linearity input output stages proposed cdta provides high output impedance port excellent input output current tracking biquad filter circuit chosen application example order demonstrate performance cdta pspice simulation results using tsmc cmos process model included verify expected values
networking become major innovation driver internet things well networks chips need effective cryptography hardware steep rise cost overall system security main challenges many application scenarios rather high throughput work present area optimized implementations lightweight block cipher simon presented cores protected side channel attacks using threshold implementation applies secret sharing different orders prevent exploitable leakages implementation results show fpgas higher order protected simon core smaller unprotected aes core security level classic cryptanalysis also proposed secure cores consume less percent power unprotected aes security proposed cores validated provable arguments well practical test based leakage detection methods fact show first order protected simon core first order leakage secure million observations higher order attacks second order secure implementation could exploited million observations
paper describes implementation automatic measuring system used acquire voltage drop gradually heated teg output without load help determine seebeck coefficient internal resistance thermo electrical generator seebeck coefficient one tegs main characteristic gives valuable information output voltage teg generate two sides maintained different temperatures thermo electrical module tem manufacturers give constant seebeck coefficient value products measurements prove fact temperature dependent purpose research accurately investigate seebeck coefficient internal resistance values depending temperature determine tems performance using experimental results propose later create improved thermo electrical model teg
multi label feature selection involves selection relevant features multi labeled datasets resulting potential improvement multi label learning accuracy conventional multi label feature selection methods final feature subset obtained identifying features high relevance low redundancy thus accurate score evaluation key factor obtaining effective feature subset however conventional methods suffer inaccurate conditional relevance evaluation large number labels involved result irrelevant features member final feature subset leading low multi label learning accuracy paper propose new multi label feature selection method using scalable relevance evaluation process evaluates conditional relevance accurately proposed method significantly improves multi label learning accuracy compared conventional multi label feature selection methods
mini abstract pre pubertal girls nutrient intakes non aquatic organized activity evaluated factors vertebral body bone mass structure strength activity vitamin dietary fiber predicted bone outcomes consistently exercise vitamin appear beneficial whereas high fiber intake appears adverse vertebral body development purpose childhood development sets baseline adult fracture risk studies evaluate development using postero anterior dual energy ray absorptiometry dxa areal bone mineral density bone mineral content bone mineral apparent density prior analysis demonstrated dxa reflects posterior element properties rather vertebral body fracture sites loading associated subtle differences vertebral body geometry density current analysis restricted pre pubertal girls focused exploration key nutrient intakes physical activity factors dual plane indices vertebral body geometry density strength methods cross sectional analysis used paired supine lateral lat lumbar spine dxa scans assess vertebral body bone mineral apparent density palatbmad index structural strength axial compression palatibs fracture risk index palatfri diet data collected using youth adolescent questionnaire yaq organized physical activity recorded via calendar based form pearson correlations backward stepwise multiple linear regression analyzed associations among key nutrients physical activity bone outcomes results accounting activity key covariates fiber unsupplemented vitamin zinc carbohydrate vitamin unsupplemented magnesium unsupplemented calcium intake explained significant variance one bone outcomes adjustment influential key nutrients covariates activity exposure associated postero anterior areal bone mineral density bone mineral content width lateral lat bmc bone cross sectional area coronal plane palatibs palatfri benefits conclusions physical activity fiber intake unsupplemented intake appear influence vertebral body bone mass density geometry strength well nourished pre pubertal girls high fiber intakes may adversely affect childhood vertebral body growth
admission flow generated parallel valve diesel engine cylinder head investigated planar stereoscopic particle image velocimetry steady flow test bench measurements swirl tumble planes combining several sets measurements full three dimensional three component reconstruction flow made flow valves forms jet collides cylinder wall flowing along wall despite fact piston recirculation bubble formed tumble plane due entrainment gas jet needs replaced thereby sets counter flow swirl plane complex jet dominated vortex structures detected close cylinder top moving away cylinder top counter rotating vortex pair structure observed single coherent swirling structure develops cylinder clear differences observed flow high moderate valve lifts correspond distinct change swirl intensity introducing strong swirling motion flow stabilized seen tracking instantaneous position swirl centre high swirl variation position swirl centre decreases substantially elsevier inc rights reserved
supervisory control data acquisition scada systems become salient part controlling critical infrastructures power plants energy grids water distribution systems past decades systems isolated use proprietary software operating systems protocols recent years scada systems interfaced enterprise systems therefore exposed vulnerabilities internet security threats traditional security solutions firewalls antivirus software intrusion detection systems fully protect scada systems different requirements paper presents innovative intrusion detection approach detect scada tailored attacks based data driven clustering technique process parameters automatically identifies normal critical states given system later extracts proximity based detection rules identified states monitoring purposes effectiveness proposed approach tested conducting experiments eight data sets consist process parameters values empirical results demonstrated average accuracy automatically identifying critical states facilitating monitoring scada system
deep brain stimulation dbs become well accepted medical therapy treatment movement disorders parkinson disease currently investigation treatment disorders including epilepsy although dbs widely used therapeutic mechanisms remain poorly understood recent research shows seizures network level phenomena incomplete knowledge neural circuit function left gap understanding disruption molecular cellular level generates epilepsy addition dbs may potentially provide opportunity selectively modulate targeted brain regions related networks therefore better understanding relationship normal neural networks epileptogenic networks well role dbs modulation neural networks help find optimal stimulation targets parameters achieve better therapeutic effect review outline recent advances relationship normal brain networks epileptogenic networks modulation dbs excitability epileptogenic networks discuss optimize dbs stimulation targets parameters taking consideration concept network modulation order improve treatment epilepsy future british epilepsy association published elsevier ltd rights reserved
children educated mothers tend healthier children less educated mothers however united states evidence relationship largely focuses summary measures health subjective health status birth weight height studies examined relationship mothers education children reported conditions health metric underlies many policy decisions concerning population health contrary stylized facts socioeconomic gradients health higher detection reporting rates may lead higher reporting rates among children educated mothers despite better underlying health reporting pattern might mirror gradients summary health measures examine possibility investigate association maternal education nine health conditions national health interview surveys consider variation maternal education gradient across specific reported conditions children experience paying particular attention patterns differ across children ages results suggest unlike income gradient child health relationship maternal education reported conditions varies magnitude direction across conditions exceptions probability reporting diagnosed condition increases maternal schooling diagnoses like asthma relationship curvilinear inverse gradient children educated mothers however probability reporting conditions require neither diagnosis substantial parent child involvement detection tends flat across maternal education contrary expectations relationships tend pronounced children years age older younger children results expand understanding production reporting early life health inequalities illustrate limitations oft used health metric reported conditions may underestimate socioeconomic inequalities children health elsevier ltd rights reserved
background emergency contraceptive pills ecp one essential commodities addressed commission life saving commodities women children although ecp available years number barriers still limit women access ecp low middle income countries lmic workforce prescribe dispense ecp diverse reflecting varied contexts ecp available across health commercial justice sectors community reviews currently exist examine roles experiences workforce provide ecp lmic method present narrative synthesis research identify provider factors facilitate constraint access ecp assess effectiveness associated interventions explore associated health system issues lmic search bibliographic databases meta indexes websites undertaken retrieve peer reviewed grey literature literature screened identified documents examined appraise quality results thirty seven documents included review studies focused formal health workers revealing knowledge gaps concerning role private sector non health providers increasingly provide ecp data findings section documents coded themes provider knowledge provider attitudes beliefs provider practice provider training analysis revealed provider knowledge gaps less favourable attitudes practice issues findings provide limited insight products prescribed dispensed frequency provision information advice offered consumers pre service training needs noted conclusion provision ecps shifts clinic based health sector increasing provision private sector limited understanding provider performance practice gaps revealed review highlight need examine provider performance inform development appropriate workforce interventions standardized approach assessing performance using agreed outcomes measures may serve ensure systematic way forward inclusive diverse workforce deliver ecp recommendations outlined enhance performance providers improve access ecp framework offered help guide process indicators
purpose purpose article describe outcomes collaborative initiative share data across five schools nursing order evaluate feasibility collecting common data elements cdes developing common data repository test hypotheses interest nursing scientists initiative extended work already completed national institute nursing research cde working group successfully identified cdes related symptoms self management goal supporting complex reproducible patient focused research design two exemplars describing group efforts presented first highlights pilot study wherein data sets various studies represented schools collected retrospectively merging cdes attempted second exemplar describes methods results initiative one school utilized prospective design collection merging cdes methods methods identifying common symptom studied across schools collecting data dictionaries related data elements presented first exemplar processes defining comparing concepts acceptable values evaluating potential combine compare data elements also described presented next steps undertaken second exemplar prospectively identify cdes establish data dictionaries methods common measurement analysis strategies included findings findings first exemplar indicated without plans place priori ensure ability combine compare data disparate sources retrospectively may possible result hypothesis testing across studies may prohibited findings second exemplar however indicated plan developed prospectively combine compare data sets feasible conducive merged hypothesis testing conclusions although challenges exist combining cdes across studies common data repository prospective well designed protocol identifying coding comparing cdes feasible supports development common data repository testing important hypotheses advance nursing science clinical relevance incorporating cdes across studies increase sample size improve data validity reliability transparency reproducibility increase scientific rigor study likelihood impacting clinical practice patient care
backgroundstereotactic body radiation therapy sbrt localized prostate cancer involves high dose per fraction radiation treatments use increasing concerns remain treatment related toxicity authors assessed incidence predictors global decline health related quality life hrqol prostate sbrt methodsfrom consecutive men localized prostate cancer received treatment sbrt according prospective institutional protocol expanded prostate cancer index composite epic hrqol data collected baseline longitudinally years epic comprised domains primary endpoint defined decline exceeding clinically detectable threshold epic domains termed multidomain decline resultsthe median age years patients unfavorable intermediate risk high risk disease received androgen deprivation therapy months months sbrt patients multidomain declines respectively multivariable analysis lower baseline bowel hrqol odds ratio confidence interval baseline depression odds ratio confidence interval independently predicted multidomain decline patients long term multidomain declines exceeding twice clinical threshold declines appeared related prostate cancer treatment progression disease conclusionsprostate sbrt minimal long term impact multidomain decline majority significant multidomain declines appear unrelated treatment emphasizes importance focusing side effects prostate cancer treatment also comorbid illnesses contribute overall hrqol cancer american cancer society cohort patients prospective health related quality life information prostate stereotactic body radiation therapy minimal long term impact clinically detectable declines global quality life baseline poor bowel function clinical depression associated increased rate multidomain decline
recent concurrence violent political rhetoric violence political targets abroad raised public concern effects language citizens building theoretical foundations aggression research fielded two nationally representative survey experiments third local experiment preceding midterm elections investigate support violence political authority subjects randomly assigned view one two forms political advertisements across three experiments mild violent metaphors multiply support political violence among aggressive citizens especially among young adults aggressive personality traits also predict support political violence national studies work identifies dynamic roots violent political orientations reveals first time surprising interactions elite discourse personality traits citizens
control system described work implements automatically digital controller achieves highest possible cross frequency specified phase margin applying design method based measured frequency response converter identified system algorithms design identification process control converter implemented soc system chip proposed algorithm calculate controller described identification process designed compensator validated measurements actual converter
focal chondral defects articular surface common occurrence field orthopaedics isolated cartilage injuries repaired surgically restoration articular congruency may high rate progression posttraumatic osteoarthritis resulting significant morbidity loss function young active patient isolated global joint disease difficult entity treat clinical setting given high amount stress weightbearing joints limited healing potential native articular cartilage recently clinical interest focused use biologically active compounds surgical techniques regenerate native cartilage articular surface goal restoring normal joint health overall function article presents review current biologic therapies discussed american orthopaedic society sports medicine aossm biologics think tank used treatment focal cartilage deficiencies emerging therapies theories application present clinical evidence specific areas future research explored focus barriers currently faced clinicians advancing success therapies clinical setting
viral genome assembled novo next generation sequencing ngs data bean bugs riptortus pedestris infected entomopathogenic fungus beauveria bassiana confirmed via race method novel insect positive sense single stranded rna virus named riptortus pedestris virus ripv genbank accession genome ripv consists nucleotides excluding poly tail contains single large open reading frame orf encoding polyprotein flanked untranslated regions utr respectively ripv genome organization end contains consensus organization picorna like rna virus helicase cysteine protease rna dependent rna polymerase rdrp addition two putative structural proteins located region poly tail end viral particles approximately diameter dispersal distinctive surface projections based phylogenetic analysis rdrp sequences ripv clustered unassigned insect rna viruses two viruses apv kfv three viruses suggested constitute new group insect rna viruses ripv could found stages lab reared bean bugs detected abundantly thorax abdomen midgut fat body reproductive organs muscle interestingly ripv replication increased dramatically bean bugs days fungal infection conclusion novel insect rna virus found ngs data assembly virus provide insight interaction virus fungus host elsevier inc rights reserved
article addresses questions first much weight given parental conflict quality coparenting relationship determining parenting time specifically respect children living least time parent joint physical custody second extent low conflict cooperative coparenting connected better outcomes children third degree children outcomes linked whether parents take custody disputes court high legal conflict fourth joint physical custody associated worse outcomes sole physical custody children whose parents conflicted uncooperative coparenting relationship recent research support idea conflict including high legal conflict rule joint physical custody arrangement best serves children interests parents joint physical custody generally significantly less conflict cooperative relationships parents sole physical custody conflict poor coparenting linked worse outcomes children joint physical custody sole physical custody quality parent child relationship better predictor conflict children outcomes exception extreme forms conflict children exposed continuing efforts improve parents relationships one another become invested helping parents maintain strengthen relationships children
eliciting sufficient high quality knowledge individuals build robust useful artificial intelligence intelligent system solution time consuming expensive activity especially domains knowledge informal partial incomplete implicit tacit unstructured moreover order develop solution systematic way incorporate elicited knowledge specification necessary goal thesis develop strategy oriented transfer transformation knowledge aim eliciting structuring quantity domain knowledge either tacit explicit incorporate specification covers needs expectations domain specialists application strategy real informally structured domain cases provides empirical insights usefulness value
objective low testosterone levels men associated increased risk cardiovascular disease aimed identify association serum testosterone level premature coronary artery disease cad predictors young adult males methods cross sectional study consecutive male candidates coronary angiography unstable angina previous cad age years included serum levels free total testosterone well demographic cardiovascular characteristics compared cad positive normal coronary subjects cutoff point low additionally relationships variables number affected vessels predictors cad assessed results study patients premature cad compared normal coronary subjects patients cad group significantly older versus years value higher rates diabetes mellitus value dyslipidemia value serum levels significantly lower cad group normal coronary subjects value rate subjects low increased number affected vessels value trend significant correlation gensini score value value respectively adjustment confounders association low cad remained significant odds ratio confidence interval value conclusion low levels testosterone associated premature cad severity young adults
background inflammatory bowel disease ibd patients persistent symptoms despite minimal inflammation frequently described overlap ibd irritable bowel syndrome ibd ibs limited data available ibs impacts individual patient ibd study aimed evaluate prevalence ibd ibs investigate impact patient reported outcomes method performed cross sectional analysis within ccfa partners study bivariate analyses logistic regression models used investigate associations ibd ibs various demographic disease factors patient reported outcomes including anxiety depression sleep disturbances pain interference social satisfaction results participants included total reported coexisting ibs diagnosis prevalence ibd ibs cohort similar within disease subtypes diagnosis ibd ibs associated higher narcotic use compared ibs diagnosis crohn disease versus ulcerative colitis indeterminate colitis versus quality life measured short inflammatory bowel disease questionnaire sibdq lower patients ibd ibs compared without ibd ibs diagnosis associated anxiety depression fatigue sleep disturbances pain interference decreased social satisfaction conclusions sample patients ibd high prevalence concomitant ibs diagnosis observed ibd ibs diagnosis associated increased narcotic use adverse patient reported outcome appropriate diagnosis treatment counseling may help improve functional status ibd ibs patients decrease narcotic use
traditional visual cryptography scheme proposed encrypt single secret image shares shares decode secret image many existing schemes visual cryptography restricted consider binary images secret appropriate many important applications store forward telemedicine one application medical images transmitted one site another via electronic medium analyze patient clinical health status main objective store forward telemedicine provide remote clinical services via two way communication patient healthcare provider using electronic medical image audio video means paper new xor based continuous tone multi secret sharing scheme suitable store forward telemedicine proposed securely transmit medical images also eliminates basic security constraints like pixel expansion shares recovered secret images random pattern shares explicit codebook requirement lossy recovery secret limitation number secret shares proposed approach multi secret sharing scheme able transmit secret images simultaneously secrets could revealed computations shares one master share master share created secret key encoding phase regenerated time decoding using secret key shares meaningful continuous tone may provide confidentiality medical images transmission proposed approach preserves basic characteristics traditional also increases capacity secret image sharing experiments found irrespective visible contents shares probability getting back pixel values respective original secret images receiver end high
fracture risk assessment tool fraxa developed collaborating centre metabolic bone diseases evaluate fracture risk patients based patient models integrate risk associated clinical variables bone mineral density bmd femoral neck clinical risk factors included frax chosen include well established independent variables related skeletal fracture risk frax tool acquired worldwide acceptance despite several limitations frax models included biochemical derangements estimation fracture risk due lack validation large prospective studies recently increasing number studies showing relationship hyponatremia occurrence fractures hyponatremia frequent electrolyte abnormality measured clinic serum sodium concentration reproducible affordable readily obtainable measurement thus think hyponatremia studied biochemical risk factor skeletal fractures prediction particularly hip carries greatest morbidity mortality achieve require collection large patient cohorts diverse geographical locations include measure serum sodium addition frax variables large numbers sexes wide age range wide geographical representation would also require inclusion data duration severity hyponatremia information required risk fracture associated occurrence length exposure hyponatremia relationship risk variables included frax also independent effect occurrence death increased hyponatremia
purpose study examine adults develop accelerated knee osteoarthritis koa greater knee symptoms certain activities without incident common koa conducted case control study using data baseline first four annual visits osteoarthritis initiative participants radiographic koa baseline kellgren lawrence knee developed advance stage koa within months common koa knee increased radiographic severity excluding accelerated koa koa change radiographic severity months focused individual items womac pain function subscales koos pain symptoms subscales index visit year person met definition accelerated common koa examine group difference knee symptoms used ordinal logistic regression models symptom results reported odds ratios confidence intervals individuals developed accelerated koa likely report greater difficulty lying pain straightening knee fully pain walking adults developed common koa individuals develop accelerated koa report greater symptoms certain activities common koa results may help identify individuals risk accelerated koa early stage accelerated koa
paper presents well documented concept synchronization low frequency oscillation occurring power systems describes characteristics sync occurring basic electrical circuits theory sync observed basic circuits extended analyze dynamic characteristics low frequency oscillation power systems
diverse perspectives science promote innovation creativity represent needs diverse populace however many science fields lack gender diversity although fewer women men pursue careers physical science technology engineering mathematics pstem women men pursue careers behavioral science current work measured relationship first year college students stereotypes science professions course completion science fields next years pstem careers associated self direction self promotion agency working betterment others communion flip side behavioral science careers associated communion greater degree agency women completed lower proportion pstem courses men gender disparity disappeared women perceived high opportunity communion pstem men pursued behavioral science courses lesser degree women disparity exist men perceived ample opportunity agency behavioral science results suggest highlighting communal nature pstem agentic nature behavioral science pre college settings may promote greater gender diversity across science fields
purpose rapid ongoing expansion urbanised impervious areas could lead frequent flood inundation urban flood prone regions nowadays urban flood inundation induced rainstorm expensive natural disaster many countries order reduce flooding risk eco roof systems green roof systems could considered effective mechanism mitigating flooding disasters rainwater retention capability however still lack examining stormwater management tool purpose paper evaluate effects flooding disaster extensive green roofs design methodology approach based geographical information system gis simulation research presents frame assessing eco roof impacts urban flash floods approach addresses urban rainfall runoff underground hydrologic models traditional impervious green roofs deakin university geelong waurn ponds campus chosen study case gis technologies utilised visualise analyse effects flood inundation surface properties building roofs findings results reveal eco roof systems generate varying degrees mitigation urban flood inundation different return period storms originality value although eco roof technology considered effective stormwater management tool commonly adopted examined urban floods study bring benefits urban planners raising awareness hazard impacts construction technicians considering disaster mitigation via roof technologies approach proposed could used disaster mitigation future urban planning
several studies commerce adoption developing countries however investigated least developed countries ldcs findings tend descriptive nature falling short theoretical contribution grounded socioculttral context purpose paper provide theoretical analysis commerce adoption ldc tanzania specifically study seeks identify structural practices associated commerce tanzanian smes using structuration theory following interpretivist stance findings show tanzanian smes enact three major commerce structural practices marketing image building use websites transacting extensive use mobile technology technical problem solving establishing partnerships practices informed organisational environmental factors define sociocultural technological economic contextual setting considerable evidence found smes use websites limited way draw upon understanding websites incompatible tanzanian cultural bargaining system characterised cash transactions face face bargaining websites viewed primarily platform smes portray sophisticated image advertise market products smes use mobile technology extensively draw technology ability offer transactive capability mobility communication findings also point technological challenges smes face environment mainly lack supporting industry institutional support smes hence establish partnerships international organisations support overcoming technological challenges partnerships large icf organisations require stringent conditions requirement smes certification order affiliated study gives practitioners better understanding smes perceive commerce tanzania amidst organisational environmental opportunities constraints practitioners better design appropriate commerce context specific policies interventions address sme problems ensure available resources become utilised effective manner without negative consequences elsevier ltd rights reserved
background partner education pregnancy may able prevent postnatal mental health problems support expectant fathers transition parenthood aim systematic review investigate effects prenatal childbirth education among partners pregnant women particularly regarding paternal postnatal mental health couple relationship methods searched medline cinahl embase psycinfo eric central using terms partners pregnant women education prenatal support searches limited randomized trials results included trials reports addressed following topics childbirth preparation couple relationship infants parenting postpartum psychosocial issues housework sharing overall risk bias low unclear study outcomes including parents mental health anxiety depression distress couple relationship parents transition adjustment parenting stress parents satisfaction experience childbirth prenatal childbirth education programs reported limitations studies included review diverse regarding intervention intensity content outcome types measurement tools outcome timing impeded evaluation interventions effectiveness conclusion sufficient evidence identified prenatal childbirth education partners pregnant women protects paternal postnatal depression couple relationship however paternal postnatal mental health important maternal perinatal healthcare results review suggest research intervention required provide partners pregnant women evidence based information support whole families perinatal period
battery energy storage bes plays important role integration intermittent renewable power distributed generation price arbitrage major source energy storage income china electricity price tightly regulated government interesting find whether bes economic viability special electricity market optimal response grid regulator facing arbitrage activities bes research starts price arbitrage model evaluate feasibility energy storage china electricity market used determine optimal investment scale operation mode energy storage quantitative assessment also implemented discuss influence factors change following optimal pricing strategy grid established results reveal storage investment realize positive profit districts price gap peak peak periods high appropriate subsidies quantitatively described sensitivity analysis terms social welfare energy storage deployed large scale low social cost suitable price mechanism elsevier ltd rights reserved
study presents novel translating piezoelectric flexible manipulator driven rodless cylinder simultaneous positioning control vibration suppression flexible manipulator accomplished using hybrid driving scheme composed pneumatic cylinder piezoelectric actuator pulse code modulation pcm method utilized cylinder first system dynamics model derived standard multiple input multiple output mimo state space representation provided second composite proportional derivative control algorithms direct adaptive fuzzy control method designed mimo system also time delay compensation algorithm bandstop low pass filters utilized consideration control hysteresis caused high frequency modal vibration due long stroke cylinder gas compression nonlinear factors pneumatic system convergence closed loop system analyzed finally experimental apparatus constructed experiments conducted effectiveness designed controllers hybrid driving scheme verified simulation experimental comparison studies numerical simulation experimental results demonstrate proposed system scheme employing pneumatic drive piezoelectric actuator suppress vibration achieve desired positioning location simultaneously furthermore adopted adaptive fuzzy control algorithms significantly enhance control performance elsevier ltd rights reserved
problem development alternative cells provides flexibility immune system crucial initiation appropriate effector mechanisms protect various pathogens bacteria viruses tumors parasites method study review research epigenetic regulation cell subsets results studies epigenetic modulation cell subset function dysfunction past years increased understanding alternative effector populations arise identity maintained clonal expansion conclusions recent advances epigenetic research within field immunology also raised questions immunology regulated pregnancy early life epigenetic regulation immune system prenatal development related diseases later life autoimmunity allergy
solving complex problem often requires way break smaller interconnected manageable sub problems join together concept breaking problem smaller pieces generally referred decomposition design mechatronic systems example complex problems based integration several disciplines mechanical electrical software engineering decomposition thus common technique help designers obtain solutions design mechatronic systems systems engineering process however effective decomposition method fully solve design problems mechatronic systems yet proposed systems engineering goal paper formalise decomposition method based interface model method applicable architecture definition context design mechatronic systems conceptual design phase proposed decomposition method provides designers high level guidance help achieve appropriate hierarchies granularities architecture mechatronic systems proposed decomposition method applied demonstrated using systems engineering practices measurement system elsevier ltd rights reserved
background antisocial personality disorder aspd researched mental disorder systematic reviews policy documents identify aspd priority area treatment research scarcity available evidence guide clinicians policymakers intervention established treatment choice disorder mentalization based treatment mbt psychotherapeutic treatment specifically targets ability recognise understand mental states oneself others ability shown compromised people aspd aim study discussed paper investigate whether mbt effective treatment alleviating symptoms aspd methods paper reports sub sample patients randomised controlled trial individuals recruited treatment suicidality self harm borderline personality disorder study investigates whether outpatients comorbid borderline personality disorder aspd receiving mbt likely show improvements symptoms related aggression offered structured protocol similar intensity excluding mbt components results study found benefits mbt aspd associated behaviours patients comorbid bpd aspd including reduction anger hostility paranoia frequency self harm suicide attempts well improvement negative mood general psychiatric symptoms interpersonal problems social adjustment conclusions mbt appears potential treatment consideration aspd terms relatively high level acceptability promising treatment effects
production commonly conceptualised equal sharing power decision making dichotomy service user service provider bringing valuable different assets process experts experience lie overlap conceptually created duality providing services virtue used services previous related studies suggest involvement production could impact positively social capital self esteem self efficacy life skills however studies explicitly psychological phenomenological nature theoretical basis outcomes remains underdeveloped phenomenological study explored psychological impact production young people paid experts experience young person mental health charity large diverse urban area looking psychological impact well theoretical semi structured interviews conducted convenience sample five males mean age years interpretative phenomenological analysis yielded three master themes production approach professional identities transition participants valued collegiate organisational approach prioritised empowerment agency equality experts experience experts qualification leading positive impact self efficacy self esteem production impacted fundamentally identity structure enabling explore new identity professional results framed within identity process theory point potential benefits model production
background lateral center edge angle lcea important measurement understanding acetabular morphology multiple interpretations misunderstanding lcea relationship acetabular dimensional morphology may result misdiagnosis poor outcomes purpose determine discrepancy bone edge sourcil edge lcea measurements anteroposterior radiographs determine anatomic location sourcil edge bone edge lcea measurements study design cohort study diagnosis level evidence methods lcea measured radiographs sourcil edge bone edge images symptomatic hips computed tomography coronal slices producing lcea matching magnitude lcea identified coronal slices mapped sagittal image acetabulum divided standard clockface anterior superior identified clockface locations corresponding sourcil edge bone edge lcea measurements paired tests identified differences magnitude location bone sourcil lceas limits agreement calculated differences measures intraclass correlation coefficients iccs assessed inter intraobserver repeatability results radiographs bone edge lcea mean degrees degrees degrees greater sourcil edge lcea sagittal clockface location sourcil edge lcea anterior compared sagittal clockface location maximum bone edge lcea respectively degrees sourcil edge bone edge measurements coronal slice corresponding sourcil edge lcea significantly anterior slice corresponding bone edge lcea significant difference similar location less pronounced hips difference degrees sourcil edge lcea occurred bone edge lcea occurred conclusion sourcil edge lcea represents anterosuperior acetabular coverage bone edge lcea represents superior lateral coverage information used preoperative evaluation perioperative planning hip preservation procedures
previous studies exploring athletes affective experience within competition neglected multivariate nature construct affective states purposes current study identify affective profiles competition examine key theoretical covariates transactional perspective affective states perceived control stress predict membership affective profiles explore issue consistency change affective profiles individual time transition probabilities examine whether precompetitive perceived control stress impact transition probabilities two hundred competitive athletes filled self report measures perceived stress perceived control intensity direction positive affect negative affect latent profile transition analysis revealed affective profiles whole low debilitators high moderate facilitators low high debilitators moderate neutrals low moderate debilitators athletes exhibited changes affective profiles time high moderate facilitators reported best psychological adjustment indicated effects covariates perceived control stress affective profiles precompetitive perceived control stress significantly predicted transition probabilities athletes change affective profiles competition whole affective profile approach may prove useful understanding affective states dynamic system implications intervention
background icrucumab icr ramucirumab ram bind vascular endothelial growth factor vegf receptors vegfr respectively open label randomized phase study evaluated efficacy safety combination capecitabine cap patients previously treated unresectable locally advanced ormetastatic breast cancer methods patients randomly assigned receive cap orally twice daily days alone combination ram intravenously days ram cap icr days icr cap every days primary endpoint progression free survival pfs secondary endpoints included overall survival tumor response safety pharmacokinetics results patients randomized received treatment median pfs confidence interval weeks ramcap weeks icr cap weeks cap hazard ratios hrs ram cap versus cap icr cap versus cap median weeks ram cap weeks icr cap weeks cap hrs ram cap versus cap icr cap versus cap statistically significant difference pfs either combination arm cap treatment related adverse events frequent ram cap cap constipation decreased appetite headache epistaxis hypertension frequent icr cap cap anemia increased lacrimation periorbital edema nausea vomiting peripheral edema facial edema dehydration dyspnea conclusion combining ram icr cap improve pfs targeted study population
non leaking green materials high content phase change materials pcm conserve solar energy contribute sustainable society paraffin encapsulated nanocellulose cnf pickering emulsion method simultaneously forming composite material thermodynamic drive phase separation confirmed molecular modeling particle formation characterized dynamic light scattering processed stable pcm cnf composites form pcm paper structures favorable mechanical properties pcm composite lightweight showed solid content paraffin morphology characterized using sem thermal regulation function pcm composite demonstrated form model roof simulated sunlight obvious leakage observed heating cooling cycles supported dsc saxs data pcm composite extended panels used energy efficient smart buildings thermal regulation integrated load bearing structures
recent studies suggest need refinement traditional two phase model relapse onset multiple sclerosis rms include dynamically changing subgroups within broad category secondary progressive spms studies challenge traditional notion relapses play minor role comparison secondary progressive perhaps degenerative process patients fulfilling broad definition spms may take several courses including variable rates patterns overall worsening new paradigms models mapping trajectory disability rms spms clinical phenotyping including periods remission may impact understanding underlying pathology important assessing treatments elsevier rights reserved
background alcohol consumption among youths related problems increasing nigeria whilst one reasons due marketing activities transnational alcohol corporations written national alcohol control policies regulate alcohol marketing nigeria methods article draws depth interviews nigerian university students aged years explore extent gulder ultimate search gus reality television show influences alcohol consumption amongst gus contestants television audiences participate gus promotional activities results results show gus popular amongst students knowledge reality show high extent able identify particular alcohol company sponsors reality television program number contestants compete prizes season contestants television viewers gus influences drinking behaviors contestants one criteria participation present recently used cans gulder beer screening exercise gus also appears influence drinking behaviors television viewers participate promotions due product placement direct advertisements promotional activities accompany fan based edition aspect gus conclusion overall gus disguised marketing strategy promote brand awareness increase sales consumption alcohol control policies regulate event sponsorship promote public health implemented nigeria
modern drives consist alternating current electric motors field oriented control foc motors enables fast precise robust regulation drive mechanical variables torque speed position control algorithm implemented microprocessor requires feedback motor currents quality feedback essential drive control properties motor phase currents sampled processed order extract mean digital control interval afterwards mean phase currents transformed rotating field oriented reference frame enable controlling mechanical variables field oriented frame rotates continuously practice transformation carried using discrete angular position paper investigates discretization impacts computed field oriented currents high speed drives rotor displacement control interval substantial continuous time model field oriented currents indicated reference quantify errors original approach normalize variables solve model analytically proposed order investigate errors related rotor position discretization influenced drive operating conditions analytical solution validated computer simulation results show currently applied methodology computing field oriented current components due invalid assumption introduces errors percent drive operates high speed errors compensated using presented solution elsevier inc rights reserved
using symbolic computation software maple generalized dirac soliton hierarchy derived new matrix spectral problem associated lie algebra hamiltonian structure yielding liouville integrability furnished trace identity elsevier ltd rights reserved
backgroundfecal incontinence prevalent poorly recognized problem general population profound negative effects daily life prevalence irritable bowel syndrome ibs association clinical demographic pathophysiological factors remain largely unknown methodsone one swedish patient cohort fulfilling rome iii criteria ibs completed rome iii diagnostic questions ibs symptoms questionnaires ibs symptom severity quality life anxiety depression work productivity impairment patients also underwent assessments colorectal sensitivity motility key resultsfecal incontinence one day per month reported usa sweden ibs patients proportions rose patients less frequent included fecal incontinence prevalence higher older age groups clear increase age irritable bowel syndrome patients reported greater overall ibs symptom severity frequent loose stools greater urgency negative effects quality life psychological distress work productivity demonstrated associations found colorectal physiology conclusions inferencesfecal incontinence common ibs patients similar previous general population reports major risk factors ibs older age rectal urgency loose frequent stools ibs patients comorbid impact quality life psychological symptoms work impairment appears greater
common existence heat transfer phenomena energy utilization systems highlights importance appropriate design optimization methods heat transfer systems unprecedented level contribution defined alternative thermal resistance heat exchangers based inlet temperature difference hot cold fluids influenced two aspects finite heat capacity rates hot cold fluids entransy dissipation based thermal resistance heat exchangers meanwhile corresponding energy flow models proposed analyze heat transfer performance individual heat exchangers three basic heat exchanger networks series parallel multi loop thermo electrical analogy method offer solution constructing energy flow models heat transfer system validation constructed energy flow model double loop thermal management system basis heat transfer characteristic described system level overall system constraints obtained kirchhoffs law without introducing intermediate variables system constraints optimization equations system derived theoretically applying lagrange multiplier method simultaneously solving equations gave optimal thermal conductances heat exchanger best allocations heat capacity rate directly benefited energy conservation energy flow model reliable convenient analysis optimization heat transfer systems elsevier ltd rights reserved
gpus become general purpose outgrowing processor model require convenient abstractions files network sockets recent studies shown benefits native gpu layers terms programmability performance however due lack hardware support gpu threads performing calls forced busy wait completion operations resulting underutilized hardware higher power consumption reduced system throughput argue driven preemption improves performance existing solutions despite many challenging system characteristics large kernel state analyze benefits adding preemption support using simple system performance model encouraged results explore design software based preemption mechanism gpus prototype gpupio implement source source compiler state checkpoint restoration runtime library scheduling preempted thread blocks together enable driven preemption gpus evaluate prototype across variety system parameters workloads determine preemption worthwhile show workloads driven preemption approach may indeed double effective system throughput completely hiding latency behind computations however also observe software solution currently limited due overheads also sufficient control hardware scheduler queue therefore may lead starvation kernels discuss new hardware feature added may render general driven preemption mechanism gpus practical
receiver operating characteristic curve popular graphical method frequently used order study diagnostic capacity continuous markers represents plot true positive rates false positive ones practical theoretical aspects receiver operating characteristic curve extensively studied conventionally assumed considered marker monotone relationship studied characteristic upper lower values bio marker associated higher probability positive result however exist real situations lower upper values marker associated higher probability positive result propose receiver operating characteristic curve generalization useful context pairs possible cut points one lower another one upper marker values taken account best selected natural empirical estimator curve considered uniform consistency asymptotic distribution derived finally two real world applications studied
background prevention sudden cardiac death transvenously implantable cardioverter defibrillator therapy icd well accepted subcutaneous system icd promising terms reducing icd complications nevertheless impact novel generator position patients quality life qol yet unknown objective study aimed comparing qol posttraumatic stress systems methods icd case controlled single chamber icd patients asked respond three standardized questionnaires pds screening posttraumatic stress disorders ptsd phq detection predominant psychological disorders used screen potential mental comorbidities questionnaire used evaluate physical mental well groups compared terms qol ptsd results pairs analyzed male mean age years prior appropriate inappropriate episodes ejection fraction underlying cardiac disease differ significantly groups pds revealed ptsd icd icd patients equally phq questionnaire icd icd patients fulfilled criteria major depression panic disorders icd anxiety disorders icd icd differ groups physical well score patients icd compared icd patients mental well score comparable groups icd icd conclusions case control study revealed equal even better physical well patients icd ptsd occurred almost icd patients irrespective type system
aggregation proteins physiological process contributes pathophysiology several maladies including diabetes mellitus huntington alzheimer disease study reported aloe emodin anthroquinone one active components aloe vera plant acts inhibitor hemoglobin aggregation thermally aggregated degrees four days evident increased thioflavin ans fluorescence shifted congo red absorbance appearance beta sheet structure increase turbidity presence oligomeric aggregates increasing concentration partially reverses aggregation model heme protein hemoglobin maximum effect observed followed saturation results confirmed visible spectrometry intrinsic fluorescence tht ans congo red assay well transmission electron microscopy tem results also supported fourier transform infrared spectroscopy ftir circular dichroism shows disappearance beta sheet structure appearance helices study serve baseline translatory research development based therapeutics diseases attributed protein aggregation elsevier rights reserved
use cases widely adopted software engineers model user system interaction however fragmented textual description functionalities inadequate user centered design concerns led human computer interaction professionals create methods techniques often opposite philosophy used software engineers modeling user system interactions therefore present paper proposes visual language use case description aiming improve support use cases user centered design projecting common artifact communication human computer interaction software engineering communities obtain perceptions potential users visual language use cases description experimental study involving software development students professionals conducted copyright john wiley sons ltd
introduction televised national hockey league nhl games include violent body checks illegal hits fights postulated minor league players imitated behaviours seeing games would reduce rate injuries among younger hockey players methods using quasi experimental design compared years televised nhl matches year nhl lock data canadian hospitals injury reporting prevention program chirpp used identify injuries ascertain whether due intentional contact illegal acts including fights results found significant differences proportions injuries involving intentional contact violations illegal acts among male minor league hockey players year professional players locked years lock conclusion concluded seeing televised nhl violence may reduce injuries although possible effect may obscured striking increase attendance equally violent minor league games lock
introduction book review analyzes complex profound impact active religious participation relationships family outcomes among african americans latinos soul mates wilcox wolfinger discuss legacy slavery jim crow laws resulting devastating effects african american latino families despite high religious involvement authors make case many african american men unlikely candidates marriage stable relationships due trends family instability driven declining income power working class men well entry women labor force government penalties low income couples revolt traditional values increased access birth control abortion persistence discrimination incarceration minority men methods authors examine data six national surveys well additional data interviews focus groups ethnographic field work extensive literature review results wilcox wolfinger find evidence african american couples actively participate christian churches men likely adhere code decency decreases street behaviors binge drinking multiple sex partners multi partner fertility known inhibit family stability conclusions book helpful health providers would like better understand serve african american latino patients findings suggest health care providers promote healthy emotional environment families encouraging minority men renew maintain church involvement
background ketosis induced humans animals fasting dietary interventions ketogenic diets however increasing interest ketogenic state motivated development alternative approaches rapidly increase ketonemia using less drastic interventions tested whether oral intake beta hydroxybutyrate beta mineral salt mixture could increase ketonemia wistar rats without dietary changes thereby useful model study ketones effects alone metabolism methods beta salts orally administered provoke elevation ketonemia effects intervention tested acutely gavage chronically weeks drinking water acutely concomitant glucose overload used suppress endogenous ketogenesis verify whether beta salts really absorbed long term administration allowed weekly evaluate impact ketonemia blood glucose weeks body weight visceral fat mass lipid blood profile serum lipolysis products adiponectinemia results beta salts increased ketonemia acute long term administrations improved blood lipid profile raising hdl cholesterol concentration decreasing ldl hdl ratio reduced visceral adipocyte volume mean ketonemia correlated positively hdlc negatively adipocyte volume serum lipolysis products conclusions oral beta rapidly increase ketonemia therefore used acute long term animal model ketosis long term treatment points important beneficial effects ketone bodies serum lipid concentrations visceral fat mass results may help explain metabolic adaptations following ketogenic diets better body fat control serum lipid profile improvement
background postpartum depression posttraumatic stress disorder ptsd identified unique risk factors poor maternal psychopathology little known however regarding longitudinal processes occurring depression ptsd among mothers childhood adversity present study addressed research gap examining occurring postpartum depression ptsd trajectories among mothers childhood trauma history methods mothers childhood trauma history reported depression ptsd symptoms months postpartum well individual shame posttraumatic cognitions dissociation contextual social support childhood postpartum trauma experiences factors results growth mixture modeling gmm identified three comorbid change patterns resilient group showed lowest levels depression ptsd remained stable time vulnerable group displayed moderately high levels comorbid depression ptsd chronic high risk group showed highest level comorbid depression ptsd path model revealed postpartum dissociation negative posttraumatic cognitions shame well social support childhood postpartum trauma experiences differentiated membership chronic high risk vulnerable finally found children mothers vulnerable group reported externalizing total problem behaviors limitations generalizability limited given sample mothers childhood trauma history demographic risk conclusions results highlight strong comorbidity postpartum depression ptsd among mothers childhood trauma history also emphasize aversive impact offspring elsevier rights reserved
manuscript report synthesis nmr single crystal structures three propylene linking dimers related hydrolytic degradation one dehydronorcantharimide dimer special attention paid conformation propylene linkers order understand changes reaction statistical analysis csd database revealed conformations may similar stability cases various complicated unpredictable non covalent interactions may play important role formation final rotamers order reproduce stable conformations energy barriers separating full range two dimensional fully relaxed potential energy surfaces pes scans six propylene linker dimers calculated starting stable crystal structures pes scanned along bridge single bond torsional angles denoted theta theta internal coordinates optimized dft blyp level gas phase energy minima optimized dft blyp level gas ethanol solutions order evaluate really stable rotamers last relaxed pes scans performed local stable rotamers get reliable energy barriers method represents less time consuming reliable approach determination conformational stability propanediyl bridging chains combination experimental statistical theoretical results shows observed conformation jointly determined energy levels minima energy barriers separating non covalent interactions somewhat randomness elsevier rights reserved
like software systems databases subject evolution time passes impact evolution vast change schema database affect syntactic correctness semantic validity surrounding applications paper performed thorough large scale study evolution databases part larger open source projects publicly available open source repositories lehman laws software evolution well established set observations typical software systems evolve matured last forty years served guide towards providing insights mechanisms govern schema evolution much like software systems found schemata expand time stabilization mechanism constraints uncontrolled expansion perfective maintenance time unlike typical software systems growth typically low long periods calmness interrupted bursts maintenance surprising lack complexity increase elsevier ltd rights reserved
issue whether video gamesviolent nonviolentharm children adolescents continues hotly contested scientific community among politicians general public date researchers focused college student samples studies video games often poorly standardized outcome measures answer questions harm minors studies arguably illuminating current analysis sought address gap focusing studies video game influences child adolescent samples effects overall video game use exposure violent video games specifically considered although analysis pathological game use overall results studies suggest video game influences increased aggression reduced prosocial behavior reduced academic performance depressive symptoms attention deficit symptoms minimal issues related researchers degrees freedom citation bias also continue common problems field publication bias remains problem studies aggression recommendations given research may improved psychological community address video games public health perspective
objective need understand potential precipitants smoking relapse exemplified relapse rates high self control strength model proposes self control dependent upon limited resources susceptible fatigue may offer insight relapse processes current study tested hypothesis self control depletion scd produced engagement emotional suppression would serve novel antecedent cessation failure indexed validated laboratory analogue smoking lapse relapse also examined whether scd effects interacted well established relapse precipitant nicotine deprivation craving behavioral economic indices delay discounting demand tested hypothesized mechanisms increased cessation failure ultimately moderated mediation model used test nicotine deprivation hypothesized moderator scd effects method used deprivation deprivation scd scd factorial subjects design smokers results primary hypothesis study supported scd increased lapse behavior nicotine deprivation significantly increased craving cigarette demand delay discounting lapse behavior main effects found scd putative mediators craving demand discounting scd deprivation manipulations interacted upon craving moderated mediation model significant scd found increase craving among nicotine deprived smokers mediated effects lapse behavior conclusions scd appears play important role smoking relapse may viable target intervention
hereditary angioedema hae rare disease associated either quantitative qualitative deficiency inhibitor inh normal inh hae normal inh associated cases mutations gene factor xii fxii fxii hae recent review described families including german spanish families constructed register french patients characteristics national survey launched french national center reference angioedema creak study clinical biological therapeutic characteristics patients hae linked mutation fxii gene fifty seven patients identified different families cases young women mean age diagnosis years mean age first symptom years female male ratio twenty one per cent patients experienced angioedema attacks pregnancy oestrogen contraception sixty three per cent attacks times severe periods male carriers mutation frequently asymptomatic females inh concentrate icatibant effective treating attacks prophylactic use tranexamic acid led decrease number attacks one largest series reported hae patients fxii mutation therapeutic management appeared identical hae inh deficiency
objectives current paper aimed explore doctor patients views treatment practitioner health programme php based service treating health professionals mental health addiction problems aims gain insights issues important patients consider whether service specifically doctors important helping overcome barriers accessing mental healthcare methods nine doctor patients attending php took part semi structured interviews september june thematic analysis used explore recurring patterns data written comments php patients also included results participants reported difficulties finding appropriate treatment problems often severe time php involved concerns confidentiality judgement impact career obstacles help seeking important issues treatment analysis written comments provided support findings conclusion whilst needs mentally unwell doctors mirror needs patients general supportive non judgemental attitude clinicians specific needs related confidentiality stigma
five experimentally characterized arterivirus species end genome coding region encodes divergent nonstructural proteins nsp nsp nsp include papain like proteases plps poorly characterized domains involved regulation transcription polyprotein processing virus host interaction present results bioinformatics analysis region arterivirus species including distantly related virus wobbly possum disease virus wpdv determined modified rapid amplification cdna ends race protocol combining profile profile comparisons phylogeny reconstruction identified association four distinct domain layouts nsp nsp major phylogenetic lineages implicating domain gain including duplication loss early nsp evolution specifically wpdv encodes highly divergent homologs plpa plpb plpc plp plpa lacking catalytic cys residue encode nsp finger znf nuclease domains conserved arteriviruses unexpectedly analysis revealed catalytically active nsp plp equine arteritis virus eav known plpb similar plpc thus likely plpb paralog non wpdv arteriviruses plpb plpa show contrasting patterns conservation terminal subdomains respectively enriched conserved residues indicative different functional specializations least conserved domain nsp hypervariable region hvr size varied fold includes four copies novel pxpxpr motif potentially recognized domain containing proteins apparently eav lacks signal directs ribosomal frameshifting nsp coding region importance arteriviruses comprise family mammalian enveloped positivestrand rna viruses include economically important pathogens swine knowledge family obtained characterization viruses five species equine arteritis virus simian hemorrhagic fever virus lactate dehydrogenase elevating virus porcine respiratory reproductive syndrome virus porcine respiratory reproductive syndrome virus present results comparative genomics analyses viruses known arterivirus species including distantly related virus wpdv whose genome sequence completed study analysis focused multifunctional end genome coding region encodes multidomain nonstructural proteins using diverse bioinformatics techniques identified many patterns evolutionary conservation specific members distinct arterivirus species characterized novel groups likely associated structural functional determinants important virus replication virus host interaction
article investigates unstable tiltrotor hover system identification flight test data aircraft dynamicswas described linear model defined body fixed coordinate system output error method selected order obtain stability control derivatives lateral motion estimating model parameters time frequency domain formulations applied improve system identification performed time domain stabilization matrix included evaluating states end estimates obtained various output error method formulations compared terms parameters accuracy time histories evaluations performed matlab environment
paper presents novel computer vision based traffic surveillance system capable processing aerial imagery track vehicles movements system uses preprocessed image sequence coverage aerial camera array mounted airplane unique characteristics input data make work challenging heuristic machine learning approaches combined evaluated detect track vehicles purpose collecting speed density volume data uninterrupted flow corridors useful big data monitoring traffic parameters entire area single sensor deep learning combined speeded robust features surf based approach able achieve accuracies speed density volume estimates respectively data compared manually collected ground truth accuracy measuring level service los uninterrupted flow facilities tested evaluations conducted facilities different levels congestion indicated different levels service research improved preprocessing higher frame rate accuracy tracking vehicles improved allow potential applications identification erratic drivers origin destination studies american society civil engineers
recent years seen growing interest distributed approaches towards stormwater management often integrated forms distributed management urban water water demand management technologies paper focuses role green roofs rainwater harvesting rwh greywater reuse integration building level number models developed simulate systems provide design curves able simultaneously minimise total runoff volumes amount potable water used building irrigation toilet flushing models developed applied design stormwater infrastructure building national gallery athens greece sensitivity analysis various model parameters conducted results suggesting inter alia significant decrease total runoff volumes rainfalls medium small return periods significant influence plant factor water requirements implications selecting vegetation mediterranean climate iii significant impact latent heat peaking months june july trade runoff volumes percentage green roof area dimensions water storage tank also investigated results suggest preferable solution conserving potable water rwh combined greywater recycling runoff minimisation best option combination green roof greywater recycling
study randomized effectiveness trial use incentives improve treatment retention post treatment outcomes among parolees community treatment parolees entering community treatment randomized incentives brief education hypothesized use incentives increase treatment retention would result improved post treatment outcomes arrest employment drug use months post intake group differences outcome secondary analyses rearrest months post intake predicted substance use greater number severity psychological symptoms treatment non completion unemployment younger age contrary expectations results indicated participants received incentives attendance arrest employment drug use outcomes similar received brief education session findings concert several researchers suggest may certain populations settings incentives may effective
power reset por power supply monitor psm control converters required circuits embedded systems mobile systems often need special power modes three functions por psm control must executed taking less current total traditional design techniques meet fatal area problem try reduce current increasing area design paper presents power management pmg system designed cmos process system part cortex based microcontroller pmg offers por psm dcdc converter control functions regulated supply por psm battery paper presents best published combination high precision variation trip voltages power consumption area number trip points observed
diabetic gastroenteropathy involves parasympathetic sympathetic autonomic nerves also enteric neurons smooth muscle cells interstitial cells cajal icc icc cells mesenchymal origin occur within around muscle layers gastrointestinal tract objective present study investigate alterations icc lower oesophageal sphincter los streptozotocin nicotinamide non insulin dependent diabetes rats moreover investigated possible icc rats type diabetes treated bilberry fruit extract bearing mind hypoglycemic effect already proven male wistar rats weeks old used diabetes induced intraperitoneal injection streptozotocin immediately intraperitoneal application nicotinamide specimens exposed anti kit antibodies investigate distribution icc smooth muscle cells immunohistochemically labelled using anti desmin antibodies intramuscular icc abundant los rats spindle shaped two long processes connecting long linear sequences los diabetic rats intramuscular icc rarely present linear cell cell connections cells completely missing groups treated bilberry number distribution icc exactly described rats induced diabetes summary decrease intramuscular icc discontinuities breakdown contacts icc observed streptozotocin nicotinamide induced diabetes rats groups treated bilberry bilberry fruit extract shown hypoglycemic activity without protective effects icc los diabetic rats
temperature variation semiconductor device operation significant affects contact resistance investigated paper reports improvements analytical modeling determining specific contact resistance scr including effect temperature technique extracting value scr using technology computer aided design tcad modeling also demonstrated scr results obtained analytical tcad models metal silicon contacts compared shows significance temperature analyticalmodel small changes electron affinity hence barrier height due changes temperaturemust considered order obtain reliable analytical expressions scr
paper presents design implementation electrical system intended powering ignition plasma burner type metallurgical furnaces furnace developed realized grounds vsb ostrava faculty metallurgy materials engineering together faculty electrical engineering computer science department electrical power engineering kat
background multiple sclerosis disease significant psychosocial adjustment challenges objective objective study assess psychosocial adjustment coping strategies patients put forth relationships design sample group comprised outpatients admitted neurology clinic university hospital treatment october july data acquired via information form psychosocial adjustment illness scale coping strategy indicator results determined patients poor psychosocial adjustment levels statistically significant relationship found psychosocial adjustment illness scale self report problem solving well seeking social support coping strategies psychosocial adjustment got worse decreasing problem solving seeking social support coping strategies patients conclusions psychosocial adjustment patients closely related effective coping strategies results emphasized significant role mental health social services coping strategies regarding comprehensive care needs patients
conventional approaches fixed point implementation digital signal processing algorithms require scaling word length optimization algorithm level high level synthesis functional unit sharing architecture level however algorithm level optimization limitations neither utilize functional unit sharing information signal grouping estimate hardware cost operation accurately study develop combined optimization high level synthesis algorithm minimize hardware implementation cost also reduce optimization time significantly software initially finds sensitivity minimum signal throughout fixed point simulations signal flow graph performs conscious high level synthesis signals similar sensitivity assigned functional unit conducts final optimization iteratively modifying wls synthesized hardware model list scheduling based integer linear programming based algorithms developed conscious high level synthesis hardware cost function minimize generated using synthesized hardware model since fixed point simulation used measure performance method applied general including nonlinear time varying digital signal processing systems fourth order infinite impulse response filter fifth order elliptic filter order adaptive least mean square filter implemented using software
defects regulatory cells treg cells aggravate multiple sclerosis onset absence treg cell functions also exacerbate course disease animal model however autoimmune neuroinflammation many models acutely provoked healthy animals leading activation encephalitogenic cells despite induction immune tolerance thymus including thymically produced treg cells contrast neuroinflammation ameliorated even completely prevented antigen specific treg cells formed extrathymically peripheral immune system ptreg cells tolerogenic responses relevant neuronal antigens review discusses specific roles treg cells blocking neuroinflammation examines impact peripheral tolerance dendritic cells relevant regulation neuroinflammation explores recent advances elucidation specific mechanisms conversion function ptreg cells including roles hopx processes
paper develops new results use model predictive control regulate speed permanent magnet synchronous motor design based linearized state space representation nonlinear model describes dynamics model predictive controller employs integral action resulting zero steady state error load torque disturbance rejection design presence constraints considered quadratic programming procedure used solve resulting line optimization problem experimental verification application industry sized motor elsevier ltd rights reserved
present paper introduces novel approach modeling governing slow dynamics near field acoustically levitated objects model sufficiently simple concise enable designing closed loop controller capable accurate vertical positioning carried object near field acoustic levitation phenomenon exploits compressibility nonlinearity viscosity gas trapped rapidly oscillating surface freely suspended planar object elevate time averaged pressure ambient pressure means vertical position loads weighing several kilograms varied dozens hundreds micrometers simplified model developed paper second order ordinary differential equation height dependent stiffness damping terms gas layer derived explicitly simplified model replaces traditional model consisting equation motion levitated object coupled nonlinear partial differential equation accounting behavior entrapped gas due relatively simple form model developed constitutes convenient foundation model based control algorithms governing slow dynamics near field acoustically levitated objects indeed based former height dependent gain scheduled pid controller developed verified numerically experimentally providing satisfying results elsevier ltd rights reserved
purpose review availability direct acting antivirals daas demonstrate remarkable clinical efficacy safety revolutionized ability treat chronic infection hepatitis virus hcv equal measure clinical success achieved persons coinfected hcv hiv historically harder cure cohort interferon based therapy global goals include identifying hiv hcv infected persons gaining access daa therapy preventing novo reinfection managing sequelae chronic infection review discuss advances field hiv hcv coinfection reported last months suggest areas future investigation recent findings expanding body literature enhanced understanding clinical epidemiologic issues surrounding hiv hcv coinfection daa therapy hcv highly efficacious hiv hcv coinfected persons drug drug interactions appropriately considered summary eradicating hcv infection persons hiv coinfection achieved safely effectively available daas economic social approaches enable access delivery curative hcv therapy hiv infected persons require continued research resource allocation
present china grain production pattern runs counter distribution patterns farmland resources water heat conditions urgently important conduct research spatial matching grain production farmland resources based potential crop rotation data regards situations irrigation rain feeding paper builds measuring model potential farmland separately measures spatial matching index grain yield actual potential farmland resources thus revealing china grain production pattern results indicate serious spatial mismatch exists grain production farmland resources china take potential crop rotation system consideration spatial mismatch grain yield potential farmland resources aggravated grain production barycenter shift north china low crop rotation index function promoting regions grain production china going two evolution patterns northward southward expansion westward movement northward expansion respectively inefficient use farmland mainly occurs fragile ecological environments farming pastoral ecotone northern china northwest area xinjiang southwest karst landform areas inefficient use decreasing amount available farmland become main causes decline grain production problems facing chinese agriculture caused spatial mismatch include imbalance regional structures ecological risks agricultural production risks risk food price order cope problems paper provides advices protecting farmland acreage expanding farmland potential ensuring safety water resources extending industrial grain chain paper additionally proposes policy reforms innovations designed ensure implementation measures commonly defuse china food security crisis elsevier ltd rights reserved
plant phenology key link controlling interactions climate change biogeochemical cycles satellite derived normalized difference vegetation index ndvi extensively used detect plant phenology regional scales introduced new vegetation index plant senescence reflectance index psri determined psri derived start sos end eos dates growing season using moderate resolution imaging spectroradiometer data inner mongolian grassland validated reliability psri derived sos eos dates using ndvi derived sos eos dates moreover conducted temporal spatial correlation analyses psri derived sos eos date climatic factors revealed spatiotemporal patterns psri derived sos eos dates across entire research region pixel scales results show psri similar performance ndvi extracting sos eos dates inner mongolian grassland precipitation regime key climate driver interannual variation grassland phenology temperature precipitation regimes crucial controlling factors spatial differentiation grassland phenology thus psri derived vegetation phenology effectively reflect land surface vegetation dynamics response climate change moreover significant linear trend psri derived sos eos dates detected small portions pixels consistent greenup brownoff dates herbaceous plant species inner mongolian grassland overall psri useful robust metric addition ndvi monitoring land surface grassland phenology
pregnane receptor pxr transcription factor regulating glycoprotein abcb mediated transport cytochrome cypa mediated metabolism xenobiotics thereby affecting pharmacokinetics many drugs potentially modulating clinical efficacy thus pharmacokinetic drug drug interactions arise pxr activation examined whether selective alpha adrenoreceptor blocker tamsulosin antagonist muscarinic receptors tolterodine affect pxr mediated regulation cypa messenger rna mrna protein level enantiomer specific way addition effect tamsulosin tolterodine activity evaluated used quantitative real time pcr gene reporter assay western blotting rhodamine efflux assay calcein assay determination expression activity inhibition glycoprotein studied compounds significantly concentration dependently increased pxr activity abcb driven luciferase based reporter gene assay observed much stronger induction abcb mrna tamsulosin compared racemic form racemic form tolterodine tamsulosin concentration dependently increased protein expression latter also enhanced efflux function rhodamine based efflux assay tamsulosin forms tolderodine slightly inhibited effect cypa expression followed pattern much weaker taken together tamsulosin tolterodine demonstrated interfere cypa regulation enantiomer specific way
depression global public health problem affecting million people people living hiv plwh twice likely suffer depression compared matched non hiv infected persons untreated depression may hasten hiv disease progression large treatment gap depression particularly low middle income countries exists however emerging evidence suggesting trained lay health workers lhw deliver evidence based treatments absence mental health professionals evidence based treatments delivered lhw contribute towards reducing treatment gap depression achieving objectives
idiopathic pulmonary fibrosis severe disease characterized excessive myofibroblast proliferation extracellular matrix fibrils deposition remodelling lung parenchyma pulmonary insufficiency drugs able reduce disease progression available therapeutic results unsatisfactory new safe treatments urgently needed poly adp ribose polymerases parp abundant nuclear enzyme involved key biological processes dna repair gene expression control cell survival death liver heart parp activity facilitates oxidative damage collagen deposition fibrosis development study investigated effects hydamtiq potent parp inhibitor murine model lung fibrosis evaluated role parp transforming growth factor tgf expression tgf smad signalling pathway lungs mice intratracheally injected bleomycin treated either vehicle different doses hydamtiq days airway resistance inflation lung static compliance markers lung stiffness assayed histochemical biochemical parameters evaluate tgf smad signalling pathway alpha smooth muscle actin sma deposition levels number inflammatory markers tumour necrosis factor interleukin inos cox performed bleomycin administration increased lung stiffness also increased lung parp activity tgf levels psmad expression sma deposition content inflammatory markers hydamtiq attenuated mentioned physiological biochemical histopathological markers findings support proposal parp inhibitors could therapeutic potential reducing progression signs symptoms disease decreasing tgf expression tgf smad transduction pathway
paper correspondence weighted line graph mason signal flow graph msfg established gives interpretation convolutional network code cnc cyclic network different perspective furthermore virtue mason theorem present two new equivalent conditions evaluate whether global encoding kernels geks uniquely determined given complete set local encoding kernels leks cnc cyclic network two new equivalent conditions turn intuitive moreover give alternative simple proof existing result
objective computational models represent novel framework understanding mechanisms behind atrial fibrillation offer pathway personalizing optimizing treatment characterization local electrophysiological properties across atria procedures remains challenge aim work characterize regional properties human atrium multielectrode catheter measurements methods propose novel method characterizes regional electrophysiology properties fitting parameters ionic model conduction velocity effective refractory period restitution curves obtained pacing protocol applied multielectrode catheter using silico dataset demonstrate fitting method constrain parameters mean error replicate conduction velocity effective refractory curves used original fitting relative error results demonstrate parameter estimation approach five clinical datasets recorded patients recordings parametrization took approx min respectively models fitted restitution curves error similar identify unique parameter set tissue properties predicted using two dimensional atrial tissue sheet model spiral wave stability case predicted using tissue simulations identifying distinct stable meandering breaking unstable self terminating spiral tip patterns different cases conclusion significance developed demonstrated robust rapid approach personalizing local ionic models clinically tractable protocol characterize cellular properties predict tissue electrophysiological function
software intelligent development become one important research trends software engineering paper put forward two key concepts intelligent development environment intellide software knowledge graph first time intellide ecosystem software big data aggregated mined analyzed provide intelligent assistance life cycle software development present architecture discuss key research issues challenges software knowledge graph software knowledge representation management framework plays important role intellide study concept introduce concrete details examples show could constructed leveraged
since theory aircraft engine electrical system complicated difficult master maintenance support personnel novel scheme simulation system design maintenance training proposed mechanical frame system based original aircraft engine electrical parts engine reconstructed dsp digital technology core communication integrated console based embedded linux developed eclipse environment experimental equipment environment virtue simulation strong interaction constituted employing electric network technology system realized functions comprising theory teaching state simulation fault setting training testing electrical network technology
four dimensional visualization approach featuring three dimensions space one dimension time proposed study local electrode degradation effects voltage cycling fuel cells noninvasive situ micro ray computed tomography xct custom fuel cell fixture utilized track cathode catalyst layer domain throughout various degradation times beginning life bol end life eol unique approach new information regarding damage features trends revealed including crack propagation catalyst layer thinning quantified means image processing analysis methods degradation heterogeneities result local environmental variations land channel also explored higher structural degradation rate channels observed density compositional changes resulting carbon corrosion catalyst layer collapse thinning observed changes relative ray attenuation bol eol also indicate possible vulnerable regions crack initiation propagation may occur electrochemical diagnostics morphological features observed micro xct correlated additionally collecting effective catalyst surface area double layer capacitance polarization curves prior imaging various stages degradation elsevier rights reserved
youth violence growing problem worldwide research adolescent violence india limited fifteen hundred high school students investigated study prevalence demographic characteristics witnesses victims perpetrators violence see impact violence exposure psychosocial adjustments sixty nine percent students witnessed violence real life serious nature media violence exposure universal prevalence victims perpetrators respectively bullying prevalent male sex important predictive risk factor witnessing perpetrating violence victims predominantly females exposure violence poorer school performance adjustment scores thus violence exposure prevalent even lives indian adolescents gender differences exist impact psychosocial adjustments detrimental early identification corrective interventions adolescents vital
important plausible impact changing global climate altered power generation hydroelectric dams project century global hydropower production forcing coupled global hydrological dam model three general circulation model gcm projections run two emissions scenarios dams simulated using detailed model accounts plant specifications storage dynamics reservoir bathymetry realistic optimized operations show inclusion features non trivial effect simulated response hydropower production changes climate simulation results highlight substantial uncertainty direction change globally aggregated hydropower production similar change mean global production high emissions scenario depending gcm several clearly impacted hotspots identified prominent encompasses mediterranean countries southern europe northern africa middle east region hydropower production projected reduced approximately average end century high emissions scenario accounting country dependence hydropower meeting current electricity demands balkans countries emerge vulnerable similar loss total national electricity generation depending country flipside handful countries scandinavia central asia projected reap significant increase total electrical production similar without investing new power generation facilities elsevier rights reserved
aimsit reported somatic treatment patients affective symptoms higher risk failure aim investigate whether affective symptoms could predict outcome sacral neuromodulation snm lower urinary tract symptoms luts methodsall patients underwent snm evaluation filled hospital anxiety depression score hads treatment included chi square analysis bivariate logistic regression used assess associations predictive value resultseighty six patients included females males patients overactive bladder syndrome oab remaining patients suffered non obstructive urinary retention thirty nine oab patients patients normal total hads score treatment significantly patients showed abnormal hads hads scores oab group compared group success snm could predicted hads score year subsequent analysis revealed abnormal hads score related occurrence snm adverse events conclusionsthe present study reveal significant relationship abnormal hads score failure snm test period mixed group oab patients however differences oab patients concerning affective symptoms present known psychological factors play role severity luts may predict snm outcome neurourol urodynam wiley periodicals inc
despite evidence effects violent video game play behavior underlying neuronal mechanisms involved effects remain poorly understood report functional mri fmri study two modified stroop tasks performed immediately playing violent nonviolent video game compared violent video game group nonviolent video game group demonstrated activation regions prefrontal cortex counting stroop task contrast violent video game group significantly stronger functional connectivity left dorsolateral prefrontal cortex dlpfc anterior cingulate cortex acc identified nonviolent video game group emotional stroop task violent video game group showed activity right amygdala less activation regions medial prefrontal cortex mpfc furthermore functional connectivity analysis revealed negative coupling right amygdala mpfc nonviolent video game group contrast significant functional connectivity right amygdala mpfc found violent video game group results suggest differential engagement neural circuitry response short term exposure violent video game compared nonviolent video game
almost research tested whether risk factors interact prediction future eating disorder onset might suggest qualitatively distinct etiologic pathways accordingly prospective study tested possible interactions risk factors prediction binge eating purging eating disorders adolescents also examined sex differences pathways risk two analytical approaches used classification tree analysis cta ideally suited identifying non linear interactions optimal cut points defining risk follow random forest analyses two way interaction terms series logistic regression models data drawn western australian pregnancy cohort raine study population based study followed participants pre birth young adulthood study involved adolescents male developed bulimia nervosa binge eating disorder purging disorder late adolescence cta sex first potent predictor eating disorder risk females showing fold increase risk relative males males females weight eating concerns next potent predictor risk three risk groups emerged reflecting non linear risk females intermediate weight eating concerns externalizing problems emerged additional predictor interaction terms logistic regression models produce significant results correcting multiple testing findings advance knowledge risk pathways eating disorder onset highlight non linear risk processes provide cut points prospectively identifying high risk youth prevention programs published elsevier ltd
three dimensional printing crossroads printer materials engineering noninvasive diagnostic imaging computer aided design structural heart intervention cardiovascular applications technology development include use patient specific models medical teaching exploration valve vessel function surgical catheter based procedural planning early work designing refining latest innovations percutaneous structural devices review discuss methods materials used printing today discuss basic principles clinical image segmentation including coregistration multiple imaging datasets create anatomic model interest applications congenital heart disease coronary artery disease surgical catheter based structural disease printing new tool challenging image plan carry cardiovascular interventions american college cardiology foundation
sintered polycrystalline cobalt ferrite potential magnetostrictive smart material applications sensors actuators novel concept enhancing magnetostrictive strain sintered cobalt ferrite making self composites nanosized bulk powders different particle sizes material components reported self composites give higher magnetostriction coefficient strain derivative compared sintered products obtained individual powders individual components give maximum magnetostriction similar ppm whereas similar ppm obtained two component system consisting powders two different sizes hand three component self composite made starting powders give high magnetostriction similar ppm suitable making devices
power wire concept novel trend modern electrical systems hence system networks become sophisticated modeling longer easy task paper propose analytical analysis global emc modern electrical network explicitly develop analytical model evaluate differential mode impedance different sites complex network end use transmission line theory applied case bifilar cables bifilar cable parameters propagation constant characteristic impedance identified measurement via impedance analyzer agilent parameters included analytical model computation process impedances computed different sites compared time impedance line impedance stabilization network lisn accordance cispr standard assess model performance carried experimental test bench measured impedances agree computed analytically
new voltage mode multifunction biquadratic filter using one differential difference current conveyor ddcc two grounded capacitors three resistors presented proposed circuit offers following attractive advantages realizing highpass bandpass lowpass notch filter functions simultaneously circuit configuration employing grounded capacitors ideal integration simpler circuit configuration
paper three stage operational amplifier low power consumption ald designed based tsmc cmos process using hspice software circuit simulation results showed proposed amp open loop gain meanwhile static power consumption less circuit phase margin degrees cmrr power supply rejection ratio
pathophysiology psychotic disorders multifactorial including alterations immune system caused exogenous endogenous factors epidemiological experimental studies indicate infections gestational period represent risk factor develop schizophrenia along lifetime tested hypothesis antipsychotic paliperidone regulates immune related brain effects experimental model well described prenatal immune activation model mice maternal injection viral mimetic poly pregnancy used young adult offspring animals pnd received paliperidone consecutive days one day last injection animals submitted cognitive test brain frontal cortex samples obtained biochemical determinations adults showed activated innate immune receptor tlr signaling pathway oxidative nitrosative stress accumulation pro inflammatory mediators nuclear transcription factors kappa inducible enzymes inos chronic paliperidone blocked neuroinflammatory response possibly synergic activation preservation endogenous antioxidant anti inflammatory mechanisms nrf ppar gamma pathways respectively paliperidone administration also stimulated alternative polarization microglia anti inflammatory profile addition paliperidone treatment improved spatial working memory deficits like animal model conclusion chronic administration paliperidone young adult mice prenatally exposed maternal immune mia challenge elicits general preventive antiinflammatory antioxidant effect intracellular cellular polarization level well ameliorates specific cognitive deficits elsevier ltd rights reserved
kidney disease disparately affects african descent age trends generally established kidney function overall population contribution age time immigration african immigrants unknown examine independent joint effects age age time immigration kidney function estimated glomerular filtration rate egfr calculated african immigrants male mean age hierarchical regression post hoc analyses revealed significant age age time immigration interaction accounting traditional risk factors among immigrated age parts per thousand currency sign younger age time immigration may exacerbate inverse relationship age kidney function self identified healthy african immigrant sample investigation biopsychosocial factors associated kidney health among african immigrants warranted
backgroundfunctional dyspepsia susceptibility might influenced polymorphisms genes related inflammation macrophage migration inhibitory factor mif motor gnb sensory dysfunction gnb trpv examined association gnb mif trpv gene polymorphisms rome iii criteria greek population methodswe genotyped dyspeptics epigastric pain syndrome helicobacter pylori positive controls using polymerase chain reaction based methods measured disease symptoms burden modified gastrointestinal symptoms related scale key resultshomozygous genotype allele gene significantly associated respectively genotypes allele frequencies gnb showed also significant association heterozygous mif genotype common dyspeptics homozygous genotype allele trpv gene prevalent controls respectively none gene polymorphism related either dyspepsia clinical syndrome type pylori infection among dyspeptics genotype related lower epigastric pain burden score genotype related higher epigastric burning nausea burden scores belching score lower mifcg dyspeptics conclusion inferencesfunctional dyspepsia susceptibility related gnb mif trpv gene polymorphisms mif gene variants also associated dyspepsia symptoms burden
paper presents extension ballistic carbon nanotube field effect transistor cntfet raychowdhury compact model adding acoustic phonon optical phonon scattering mechanisms mechanisms cause noise device obtain accurate compact model flicker thermal noise models included model easily implemented hardware description language hdl like verilog agilent advanced design system simulation tool ads impact scattering mechanism operational amplifier amp circuit performances investigated simulation results compared respect amp including scattering amp using ballistic model hence degradation amp performances scattering models observed especially gain bandwidth figure merits addition increase flicker noise device
rapid development new technologies information management knowledge extraction evaluation fusion well introduction new computational paradigms supporting task great influence creation future generation computer systems innovative efficient information services management solutions grid environment pervasive computing computational paradigms important especially performing semantic analysis acquired information providing distributed remote services considering user preferences social requirements additionally considering management activities large infrastructures like cloud computing big data repositories new approaches focus collecting processing intelligent searching dissemination information collected different sources enable perform deeper analysis considering semantic meaning evaluation data structures personal preferences data may applied information services management data distribution global network information society pervasive ubiquitous management paradigms based advanced ambient technologies like cyber world smart cities virtual reality paper presented several selected approaches development management technologies important scientific practical points view published elsevier
development water saving cultivation techniques attracting increased attention worldwide rainwater harvesting system known ridge furrow plastic film mulching rfpfm gradually become promising cultivation method semiarid rain fed ecosystems china however well documented whether system practiced semi humid region irrigation available field studies comparing three cultivation patterns rainfed flat planting rfpfm well irrigated planting pattern across two different nitrogen rates two cultivars conducted two consecutive years assess potential role rfpfm improving water use efficiency wue winter wheat dry semi humid region northwest china high soil moisture favourable temperature seedling establishing period topsoil rfpfm practice contributed emergence seedlings days earlier superiority also resulted longer growth duration also resulting earlier spikelet spike differentiation thereby increasing grain number per spike spike number per wheat yield rfpfm practice compared highest yield achieved combined higher application condition rfpfm practice resulted approximately yield treatment higher application increasing wue compared practices respectively addition rfpfm practice comparison increased fertilizer productivity uptake efficiency respectively averaged across others treatment years highly recommend rfpfm practices rate water saving technology promising strategy increase wheat yield wue current agro ecosystem northwest china elsevier rights reserved
failure key parts bearings gears cutting drum long chain gear driving system long wall shearer crucial factor service life gear systems short driving system driven multiple electric motors cutting drum proposed alternative long chain gear driving system electromechanical dynamic model based lumped parameter method short driving system established considering effect intrinsic mechanical characteristic electric motor taking account time varying stiffness damping electric motor synchronization error manufacturing eccentric error transmission error gears load sharing characteristic dynamic characteristic multiple motor driving unit mmdu short driving system analyzed shock load results simulation show electric motor synchronization error significant effect load sharing characteristic mmdu load sharing coefficient evidently increases electric motor synchronization error decreasing electric motor synchronization error improve load sharing characteristic mmdu synchronization error must controlled fewer ensure load sharing coefficient mmdu imbalance dynamic meshing force distribution pinions mmdu obviously decreased load sharing characteristic mmdu greatly improved controlling synchronization error electric motor effect unobvious controlling manufacturing eccentric error transmission error provides effective method choose suitable control ranges different synchronization errors electric motor according different load sharing requirements mmdu
numerous studies repeatedly shown women smoke experience problems establishing maintaining pregnancies recent work demonstrated utero effects smoke may manifested months even years birth purpose review examine recent literature dealing effects cigarette smoke earliest stages human prenatal development studies area included use animal models patients undergoing vitro fertilization embryonic stem cell models events leading fertilization cumulus expansion hyperactivation sperm motility oocyte pick oviduct impaired smoke exposure animal models steps crucial fertilization acrosome reaction sperm binding zona pellucida likewise inhibited cigarette smoke preimplantation embryos stem cells model embryos show number adverse responses smoke exposure including poor adhesion extracellular matrices diminished survival proliferation increased apoptosis current literature demonstrates earliest stages prenatal development sensitive smoke exposure indicates pregnant women advised smoke time
orally administered plant cell expressed recombinant anti tnf fusion protein prx consists soluble form human tnf receptor tnfr fused component human antibody igg domain aim evaluate immune modulatory effect oral administration plant cells expressing prx methods mice treated concanavalin cona induce immune hepatitis orally treated cells expressing prx containing prx colitis model tnbs colitis induced mice followed oral administration plant cells expressing prx immune modulatory effect determined follow assess clinical effect histology serum cytokine levels facs analysis lymphocyte subsets results oral administration cells expressing prx alleviated immune mediated liver injury serum ast alt levels decreased comparable mice received high dose steroids beneficial effect also observed marked decrease hepatic necrosis colitis model oral administration plant cells expressing prx alleviated weight loss associated immune mediated colitis improved bowel histology reduction ikb alpha phosphorylation treated mice also observed effects associated significant alteration distribution foxp cells conclusions plant cells expressing recombinant anti tnf fusion protein show biological activity orally administered exerting immune modulatory effect alleviation immune mediated hepatitis immune mediated colitis elsevier gmbh rights reserved
low contrast letter acuity lcla emerged leading outcome measure assess visual disability multiple sclerosis research visual dysfunction one common manifestations sensitive visual outcome measures important examining effect treatment low contrast acuity captures visual loss seen high contrast visual acuity hcva measurements issues addressed outcome assessments consortium msoac including representatives advocacy organizations food drug administration fda european medicines agency ema national institute neurological disorders stroke ninds academic institutions industry partners along persons living msoac goals acceptance qualification regulators performance outcomes highly reliable valid practical cost effective meaningful persons critical step elucidation clinically relevant benchmarks well defined degrees disability gradients change clinically meaningful review shows disease free controls similar median hcva patients significantly lower lcla deficits lcla vision specific quality life found many years episode acute optic neuritis even hcva recovered studies reveal correlations lcla expanded disability status score edss multiple sclerosis functional composite msfc retinal nerve fiber layer rnfl ganglion cell layer plus inner plexiform layer gcl ipl thickness optical coherence tomography oct brain magnetic resonance imaging mri visual evoked potential vep electroretinogram erg pupillary function king devick testing review also concludes point change lcla clinically meaningful overall goal review describe characterize lcla metric research clinical use among persons
five experiments investigated effects spatial elevation person perception computer setup actual encounters determining moderating role additional verbal information target accordance prior findings spatial elevation increased respect computer setting especially target described nonachieving liking toward target affected actual encounter results reversed actually facing target spatial elevation decreased respect legitimized achievements target discuss implications findings elicitation respect experimental approaches investigate
eating disorders highest mortality rate psychiatric disorders high incidence comorbidity average age onset care typically befalls family members however despite severity disorder burden placed family research caregiving experience still developing studies shown caregivers individuals experience high levels distress burden expressed emotion recent theoretical models underscored importance caregivers responses maintenance factor family therapy proved efficacious however literature pertaining experience family members living caring individual systematically reviewed review aimed synthesize qualitative studies relating caring experience impact thereby gaining understanding perspective individuals relevant search terms utilized systematically search key databases twenty studies total sample participants met inclusion criteria nine core themes emerged synthesis forming basis explanatory theory found pervasive impact upon family members mediated number factors cognitive appraisals affected caregiving experience responses individual experience caregiving continually reappraised leading process adaptation majority studies identified unmet carer needs implications findings discussed reference existing theoretical models terms clinical practice copyright john wiley sons ltd
purpose purpose paper focus machine design control strategy permanent magnet synchronous generator pmsg system especially utilized variable speed applications order stabilize output voltage link wide speed range design methodology approach different power converter topologies comparatively studied accordingly designed pmsg investigate influence armature winding inductance well relationship pmsg power converter topologies findings pulse width modulation pwm rectifier preferable said application due good performance controllability moreover employing pwm rectifier relatively large inductance pmsg considered short circuit current reduction field regulation originality value field regulating control realized space vector pwm svpwm rectifier weaken pmsg magnetic field high speed operation even properly enhance field low speed ensuring small change pmsg output voltage stable voltage
reduction fuel consumption emissions indispensable part automotive industry recent years caused plug hybrid electric vehicle phev taken consideration main objective paper developing predictive optimized control strategy based traffic condition prediction minimizing emissions purpose initially traffic condition predicted utilizing driving cycle classification based specifications control strategy based fuzzy logic controller flc developed various driving conditions membership function parameters rules tuned employing genetic algorithm next step recognition prediction upcoming traffic condition control strategy switched optimized flcs enhance optimal power split sources manage internal combustion engine ice work vicinity optimal condition finally effects control strategy mass aerodynamic parameters phev performance energy usage components investigated simulation results indicate proposed approach real world driving condition reduces emissions significantly published elsevier ltd
paper investigates integrability generalized seventh order korteweg vries equation arising fluids plasmas means singularity structure analysis proven equation passes painleve test integrability three distinct cases three sets painleve integrable conditions soliton solutions obtained using hirota bilinear method pseudopotentials lax pairs derived virtue method developed nucci finally infinite conservation laws found using lax pair conserved densities fluxes presented explicit recursion formulas
despite successful implantation jude medical bileaflet mechanical heart valves red blood cell lysis thrombogenic complications associated types valves yet addressed previous study proposed elliptic housing ovality applied housing jude medical valves preliminary results suggested overall hemodynamic performance jude medical valves improved closing opening phases study evaluated hemodynamics around leaflets opening phase using sophisticated computational platform computational fluid dynamics results suggested lower shear stress wall shear stress values overall improved hemodynamic performance proposed design improvement characterized lower values shear stress wall shear stress regions downstream leaflets lower pressure drop across valve smaller recirculation zones sinuses areas proposed design may open new chapter concept design hemodynamic improvement next generation mechanical heart valves
semantic web uses resource description framework rdf simple protocol query update languages sparql sparul standardized logical data representation manipulation models allowing machines directly interpret data web semantic web applications grow increasingly popular new challenging security threats emerge semantic query languages owing flexible nature introduce new vulnerabilities secure programming practices followed makes prone existing attacks command injection well novel attacks making necessary application developers understand security risks involved developing deploying semantic applications research analyzed categorized possible sparql sparul injection attacks semantic applications vulnerable moreover developed deliberately insecure rdf based semantic web application called semwebgoat inspired open source vulnerable web application webgoat offers realistic teaching learning environment exploiting sparql sparul oriented injection vulnerabilities aim teaching developers web administrators art protecting semantic web applications implemented web application firewall waf rules using popular open source firewall modsecurity extended penetration testing tools detect mitigate sparql sparul injections evaluation conducted user study determine usability semwebgoat attack lessons well detection rate false alarm analysis proposed firewall rules based owasp top ten attack dataset results user study conclude web developers normally familiar injection vulnerabilities demonstrated positive test results modsecurity rule set show suitable defense mechanism protecting vulnerable semantic web application injection attacks elsevier ltd rights reserved
infertility due low testosterone levels increased recent years impacted social well patients study undertaken investigate potential gonadotropins facilitating differentiation human bone marrow mesenchymal stem cells bmscs leydig cells vitro bmscs isolated cultured biological characteristics observed bmscs induced gonadotropins vitro ability differentiate leydig cells studied level expression beta hydroxysteroid dehydrogenase beta hsd secretion testosterone determined using flow cytometry enzyme linked immunosorbent assay respectively results compared experimental control groups cultured bmscs showed typical morphology fibroblast like colony growth curve cells formed shape inducing cells days cells experimental group increased size showed typical characteristics leydig cells growth occurred spindle stellate shapes cells experimental group highly expressed beta hsd gradual increase number leydig cells control group express beta hsd level testosterone experimental group higher control group additionally cells experimental group secreted higher levels testosterone increased culture time expression leydig cell specific markers experimental group significantly higher findings bmscs considered new approach treatment patients low androgen levels copyright kaohsiung medical university published elsevier taiwan llc
background alveolar epithelial cell injury proposed causative factor onset progression pulmonary fibrosis however role type alveolar epithelial cells aecs epithelial mesenchymal transition emt controversial aims present study performed rats instilled bleomycin investigated expressions insulin growth factor igf insulin growth factor binding protein igfbp transforming growth factor tgf beta type aecs role type aecs emt extracellular matrix ecm formation effect pioglitazone parameters methods male wistar rats divided three groups group saline control group bleomycin given single intratracheal instillation group iii bleomycin pioglitazone day orally starting days post bleomycin instilled group lung tissues protein expressions igf igfbp tgf beta surfactant protein marker type aecs alpha smooth muscle actin alpha sma marker emt determined day groups days three groups results igfbp igf expressions reduced significantly tgf beta expression increased significantly type aecs group day till day compared group increase sma expression localization seen type aecs undergoing emt day till day concomitant remodeling laying ecm observed also group iii pioglitazone reversal significant regulation igfbp igf expressions regulation tgf beta type aecs along significant decrease solid area fraction emt ecm lung tissue conclusions igfbp igf tgf beta type aecs play key role lung injury caused bleomycin pioglitazone attenuates lung injury fibrosis restoring igfbp igf decreasing tgf beta expressions type aecs published elsevier inc
background management acute agitation manifesting patients schizophrenia bipolar disorder requires swift pharmacological intervention provide rapid symptomatic relief prevent escalation aggression violence antipsychotic medications widely used setting availability inhaled formulation deep lung absorption antipsychotic loxapine potential deliver faster onset therapeutic effect available intramuscular formulations antipsychotics methods efficacy inhaled loxapine alternative antipsychotic aripiprazole delivered via intramuscular injection compared phase iiib placid study adults years confirmed diagnosis schizophrenia bipolar disorder presenting acute agitation randomly assigned open label treatment ratio clinical evaluation conducted raters blinded treatment assignment primary efficacy endpoint time response defined clinical global impression improvement cgi score much improved much improved secondary endpoints include percentage responders different time points dosing proportion patients receive doses study drug time second dose time rescue medication satisfaction study drug evaluated using item treatment satisfaction questionnaire medication safety tolerability approximately patients recruited interim analysis conducted patients completed study decide whether stop futility continue without increase sample size additional patients discussion placid trial assess efficacy safety inhaled loxapine deep lung absorption compared antipsychotic aripiprazole acutely agitated patients schizophrenia bipolar disorder event median time response inhaled loxapine significantly shorter intramuscular aripiprazole placid study potential support inhaled antipsychotic therapy standard care setting
traditionally irritable bowel syndrome ibs regarded organic disease pathophysiology ibs heterogeneous currently diagnosis ibs based upon rome diagnostic criteria performance criteria modest predicting ibs moreover validation lacking additionally functional symptoms common general population healthy controls volunteers difficult define currently definition normal rome criteria due weaknesses current diagnostic criteria patients doctors expect new gold standard diagnostic tools various etiologic mechanisms result potential biomarkers focus research find non invasive biomarkers serum breath gas fecal materials though biomarkers based biological pathogenic processes biomarkers ibs developed identify organic diseases therefore eliminate ibs date types biomarkers ibs disappointing purposes developing biomarkers include improvement diagnosis differentiation organic diseases discrimination ibs subtypes true mechanistic biomarker would make possible rule ibs rather rule organic diseases new serologic biomarkers diarrhea predominant ibs introduced based pathophysiologic findings rat model validation large scale clinical trial investigations abnormal organic findings subtype ibs would enable development new simple subtype specific biomarkers
degree parallelism increasing performance multi threaded shared variable applications limited serialized critical section execution also serialized competition overhead threads get access critical section number concurrent threads grows competition overhead may exceed time spent critical section become dominating factor limiting performance parallel applications modern operating systems queue spinlock comprises low overhead spinning phase high overhead sleeping phase often used lock critical sections paper show advanced locking solution may create high competition overhead multithreaded applications executing noc based cmps propose software hardware cooperative mechanism opportunistically maximize chance thread wins critical section access low overhead spinning phase thereby reducing competition overhead primitives level monitor remaining times retry rtr thread spinning phase reflects long thread must enter high overhead sleep mode hardware level integrate rtr information packets locking requests let noc prioritize locking request packets according rtr information principle smaller rtr locking request packet carries higher priority gets thus quicker delivery evaluate opportunistic competition overhead reduction technique cycle accurate full system simulations gem using parsec programs spec omp programs benchmarks compared original queue spinlock implementation experimental results show method effectively increase opportunity threads entering critical section low overhead spinning phase reducing competition overhead averagely maximally accelerating execution region interest averagely maximally across benchmark programs
note analyzes relationship economic crises tourism performance spain period using machine learning techniques specifically regression tree estimated confirm although dynamics spanish tourism performance influenced general variables established literature crisis periods disrupt natural functioning dynamics provoking disturbances affect tourism market position destinations greater extent expected conversely econometric techniques machine learning approach allows achieve greater flexibility enriches information estimating interrelations thresholds operating context
australian education service provision includes delivery quality educational programmes rural remote living children however according parents many children developmental disabilities syndrome autism spectrum disorders living rural country areas new south wales nsw still access acceptable education programme study aimed use quality life factors via family quality life scale explore parents experience educational service provision children developmental disabilities rural nsw results indicated successful engagement school system strongly affected views assumptions expertise prejudices teaching care professionals research local educational service providers may assist rural australian families child idd rural remote locations warranted
daclatasvir dcv potent pangenotypic hepatitis virus hcv non structural protein inhibitor low potential drug interactions antiretroviral therapy art evaluated safety efficacy dcv plus peginterferon alfa ribavirin pegifn rbv hiv hcv genotype coinfected patients nct open label phase iii single arm response guided treatment rgt study included patients received dcv doses daily depending concomitant art plus weight based rbv day day weekly pegifn weeks required rgt pegifn rbv without dcv extended additional weeks therapy primary endpoint proportion patients sustained virologic response post treatment week svr overall patients achieved svr lower bound confidence interval higher historic svr rate pegifn rbv alone common adverse events aes fatigue neutropenia anemia asthenia headache treatment serious aes occurred patients discontinued treatment due dcv pegifn rbv led sustained hcv virologic response majority hiv hcv coinfected patients regardless concomitant art hiv control compromised new safety signals identified study supports dcv use hiv hcv coinfected patients allowing vast majority patients remain existing art regimen
two experimental studies conducted aimed testing whether activation positive meta stereotypes among high status group members involved conflictual relationships low status group beneficial intergroup relations results revealed activation positive meta stereotypes led italian high school students high status group anticipate greater enjoyment upcoming interaction african immigrant low status group increasing positive feelings contact concerns accepted initial prejudice emerged moderator effects positive meta stereotypes present among average high levels prejudice study represents first experimental demonstration positive meta stereotypes beneficial effects intergroup relations among high status members theoretical practical implications findings discussed
bioethics health policy often discuss appropriate boundaries public funding interface public private purchasers providers organized regulated receives less attention paper discuss ethical regulatory issues raised interface three medical practice models concierge care executive wellness clinics block fee charges physicians provide insured services whether publicly insured privately insured privately insured public mandate requiring requesting patients pay services non insured services physicians associates choice practice models different decision design insurance plan include exclude user fees payments deductibles analyze issues raised regards familiar health care values equity efficiency highlighting additional concerns fair terms access provider integrity fair competition analyze common canadian regulatory response block fee models considering extension wellness clinics regards fiduciary standards governing physician patient relationship role informed consent close highlighting briefly issues common concern across different fundamental normative frameworks health policy
heterogeneous nanostructures quanturn dots qds embedded solid matrices core shell nanoparticles promising platforms wide variety applications including phosphors increased quantum yield photocatalysis solar energy conversion however characterizing controlling interfacial morphology defects greatly influence electronic properties proven difficult numerous cases carried atomistic calculations chalcogenide nano structured materials pbse qds cdse matrices cdse embedded pbse established interfacial core structures affect electronic properties particular showed defects present interfaces pbse nanopartides cdse matrices give rise detrimental intragap states degrading performance photovoltaic devices instead electronic gaps inverted system cdse dots pbse clean indicating material superior electronic properties solar applications addition calculations predicted core structure cdse turn band gap may tuned applying pressure pbse matrix providing means engineering properties new functional materials
since power demand increasing decades recent researches electrical generator topologies developed switched reluctance generator pointed great choice since shows simple structure robustness low cost order driven properly control technics allow stable voltage values power system suffers disturbances operation work deals fuzzy voltage controller switched reluctance generator simulations experimental results carried order evaluate control robustness results presented paper
lipophilic yeast malassezia species widely found skin surface humans animals fungus cause pityriasis versicolor malassezia folliculitis seborrheic dermatitis still problem species identification malassezia conventional methods developed real time polymerase chain reaction pcr assay multiple hybridization probes detecting globosa furfur restricta sympodialis slooffiae pachydermatis amplification curves specific melting peaks probes hybridized real time pcr product used species identifications assay evaluated samples performed swabbing domestic animals goats dogs cows cats rabbits donkey human samples patients pityriasis versicolor breeders control group fifteen pachydermatis identified animals human isolates identified globosa furfur restricta sympodialis slooffiae pachydermatis eight cases detection patients breeders revealed findings show assay highly effective identifying malassezia species application multiplex real time pcr provides sensitive rapid identification system malassezia species may applied epidemiological surveys clinical samples
objective examine intertester reliability validity nonradiologic measures forward flexed posture individuals parkinson disease design cross sectional observational study setting university outpatient facility community centers participants individuals hoehn yahr scores interventions applicable main outcome measures occiput wall status tragus wall distance wall distance photographically derived trunk flexion angle inclinometric kyphosis measure results participants older adults mean month year mean history intertester reliability excellent measures cued condition relaxed condition occiput wall status intraclass correlation coefficients tragus wall distance wall distance flexion angle inclinometric kyphosis measure convergent validity supported measures significant correlations measures obtained relaxed cued conditions occiput wall relaxed cued measures significant correlations measures obtained condition occiput wall cued tragus wall cued significant correlations tragus wall distance wall distance flexion angle inclinometric kyphosis measure unified parkinson disease rating scale item posture also supported convergent validity significant differences tragus wall distance wall distance inclinometric kyphosis measure values relaxed cued conditions supported known condition validity known group validity demonstrated significant differences tragus wall distance wall distance inclinometric kyphosis measure obtained individuals able individuals unable touch occiput wall cued stand tall conclusions tragus wall distance wall distance inclinometric kyphosis measure reliable valid nonradiologic measures forward flexed posture american congress rehabilitation medicine
view high biotoxicity trace concentration mercury environmental water developing simple ultra sensitive highly selective method capable simultaneous determination various species attracted wide attention present novel catalysis reduction strategy sensing inorganic organic mercury aqueous solution cooperative effect aunp catalyzed properties formation gold amalgam first time new aunp catalyzed organic reaction discovered directly used sensing chhg according change amount catalytic product induced deposition atoms surface aunps detection limit species ppt orders magnitude lower environmental protection agency epa limit value drinking water ppb high selectivity exceptionally achieved specific formation gold amalgam moreover application detecting tap water samples demonstrates aunp based assay excellent method used sensing mercury low content environment
present paper focuses nonverbal communication elements correlated leadership behaviours military junior leaders constructs affect superior performance followers data show facial expression smile eye behaviour ones positive pronounced correlation subordinate perception self confidence self control courage empathy influence reference commanders factors extraordinary effort satisfaction also positively related contrary gestures crossed arms point one finger negative correlation subordinate perception self confidence self control courage empathy influence reference commanders case factors extraordinary effort satisfaction also negatively related conclude use certain gestures may contribute positive negative perception commander followers thereby influencing performance
paper reviews recent literature factors influencing suicide behaviours including thoughts plans attempts immigrant ethno cultural minority groups inform comprehensive understanding suicide behaviours increasingly culturally diverse populations thirty three studies published identified digital databases searches included review analysis study findings focused impacts ethno cultural identity acculturation cultural immigration influences family community supports suicide behaviours policy practice research recommendations identified inform relevant suicide prevention efforts enhance mental health supports immigrant ethno cultural minority populations
switched systems theory used analyze stability image based observers three dimensional localization objects scene presence intermittent measurements due occlusions feature tracking losses limited camera field view example generally observers filters exponentially stable persistent measurement availability may unbounded error growth intermittent measurement loss even providing seemingly accurate state estimates constructing framework utilizes state predictor periods measurements available class image based observers shown exponentially convergent presence intermittent measurements average dwell time total unmeasurability time condition satisfied conditions developed general form applicable observer exponentially convergent assuming persistent visibility utilizes object motion knowledge reduce amount time measurements must available maintain convergence guarantees based stability results simulations provided show improved performance compared zero order hold approach state estimates held constant measurements available experimental results also included verify theoretical results demonstrate applicability developed observer predictor design compare typical approach using extended kalman filter
osteopontin opn extracellular matrix ecm glyco phosphoprotein plays important role autoimmune mediated demyelinating diseases including multiple sclerosis experimental autoimmune encephalomyelitis eae integrin binding protein participates bidirectional communication ecm target cells affects transduction pathways maintain neuronal immune cell homeostasis biological activity also heavily influenced microenvironment stimulates cleavage opn changes functions study estimated expression profile opn neural tissues rats first relapse chronic relapsing eae investigated relationship opn metallothionein mts play pivotal role zinc related cell homeostasis protection cns cytokine induced injury data showed eae rats opn mrna protein levels increased concurrently transcription mts within spinal cord lysates eae afflicted rats higher content opn fragments low molecular weight untreated cfa treated rats expression opn mts upregulated ependymal lymphoid astroglial cells multiple alpha beta neurons brain cortex white matter hippocampus cerebellum besides multiple cells expressed opn mts granular opn signals detected secretory vesicles golgy alpha beta neurons patches adjacent plasma membrane subventricular zone findings imply demyelinating lesions generated proteolytic opn fragments opn interactions contribute tissue remodeling autoimmune attack author published elsevier ltd behalf ibro
study designed ambient intelligence ami based decision support system combined electromagnetism like mechanism sensory data aid human operators making decisions regarding management cascade hydropower systems currently cascade hydropower systems primary source hydropower taiwan dajia hydropower system largest one taiwan operational considerations various plants system include water levels constraints minimal water release constraints maximal water release constraints considerations must emphasized plan hourly water release rate maximize power generation profitability overall system although extant operations viable accurate calculation method maximizing economic efficiency hydropower generation yet developed ami based system proposed study used determine periodic water release plant system thereby maximizing company power generation profit addition proposed system compared scheduling system currently employed dajia hydropower system scheduling operations dajia hydropower system nonsummer days whole year examined respectively hydropower plant original scheduling method compared proposed system test results indicated scheduling plan obtained proposed system increased profit taiwan power company
significance recently chronic degenerative diseases become one main health problems worldwide case alzheimer disease metabolic syndrome mets whose expression influenced different risk factors recent advances recent decades widely described mets increases risk cognitive impairment dementia mets pathogenesis involves several vascular risk factors diabetes dyslipidemia hypertension insulin resistance critical issues reported evidence shows vascular risk factors associated particularly development protein aggregation inflammation oxidative stress neuronal dysfunction disturbances signaling pathways insulin receptor signaling common alteration mets future directions insulin signaling involved tau phosphorylation amyloid beta beta metabolism however also demonstrated beta oligomers bind insulin receptors triggering internalization decreasing neuron responsiveness insulin promoting insulin thus could argued beta could convergent factor development pathologies
evaluate effect crude protein source combination feeding strategies libitum restricted performance health status carcass traits growing fattening rabbits age two experimental diets formulated first containing soybean meal sbm main source second containing white lupin seeds wls main source total weaned hyplus rabbits live weight randomly allocated experimental groups combination feeding strategy diet sbm sbm wls wls rabbits per group rabbits per cage feeding programme applied follows sbm wls rabbits fed libitum entire fattening period whereas sbm wls rabbits subjected feed restriction age libitum intake afterwards restricted rabbits fed libitum age regardless source feed restriction reduced final live weight chilled carcass weight dressing percentage percentage points higher chilled carcass weight reference carcass weight rabbits fed wls diet rabbits fed sbm diet dead morbid rabbits observed restricted rabbits restriction period effect diet health rabbits however rabbits sbm wls group compared observe lower number rabbits sanitary risk wls group rabbits conclusion growth performance affected crude protein source interaction dietary source feeding regime observed feed restriction regime improve sanitary risk index throughout entire period
study objectivea substantial proportion antipsychotic use veterans nonapproved indications label prescribing label use necessarily detrimental patients however certain situations label prescribing could considered justifiable objective study determine extent label prescribing veteran population potentially appropriate designexpert panel retrospective analysis data sourceveterans health administration vha corporate data warehouse patientsa total veterans least one pharmacy record medication fiscal years measurements main resultsan expert panel convened determine agreement exists appropriateness use various scenarios panel consisted experts field psychiatry nine physicians various specialties one pharmacist used modified rand appropriateness method approach identify potentially appropriate uncertain inappropriate cases use use six second generation aps examined individually use first generation aps examined class based data previously collected quantifying vha use panel given disease state scenarios commonly occurring label diagnoses prescriptions disease states coupled scenario modifiers expert panel considered potentially significant clinical factors among four disease statesanxiety dementia insomnia posttraumatic stress disorder scenarios investigated none scenarios judged expert panel appropriate use aps scenarios aps judged inappropriate expert panel remaining considered uncertain medications risperidone olanzapine likely seen uncertain whereas first generation aps likely considered inappropriate given scenario widespread label use aps outside approved indications treatment schizophrenia bipolar disorder adjunctive treatment major depressive disorder may appropriate treatment option according expert panel examined situations considered appropriate use aps conclusionthe consensus expert panel label use uncertain best likely even complicated cases inappropriate findings strengthen case stronger control aps integrated health care settings vha well better education information practitioners provide care patients anxiety dementia insomnia posttraumatic stress disorder
psychotherapists researchers agree good relationship essentially contributes therapeutic change psychoanalytic concepts transference countertransference describe fundamental aspects psychotherapeutic relationship become integrated behavior therapy concepts however used differently psychoanalysis well behavior therapy makes communication psychotherapists coming different orientations difficult therefore research approach describes important verbal nonverbal elements helpful therapeutic interaction independently therapeutic orientation could help evaluate effectiveness different psychotherapeutic methods way culture integration psychotherapy could encouraged
impact synchronous modal analysis isma uses impact synchronous time averaging ista allows modal testing performed operation ista effective filtering non synchronous cyclic load component harmonics noises however found operating speeds coincide natural modes isma would require high number impacts determine dynamic characteristics system finding subsequently reduced effectiveness practicality isma preservation signatures ista depends consistency phase angles every time block necessarily frequencies thus effect phase angles respect impact seen important parameter performing isma structures dominant periodic responses due cyclic load ambient excitation responses unaccounted forces contain even frequency contained response due impact diminished least number impacts phase periodic responses consistent impact signature every impact applied assessment showed small number averages sufficient eliminate non synchronous components improvement simulation improvement experimental modal testing phase angles respect impact consistent every impact applied
objective investigate relationship specific television viewing habits sleep habits sleep disturbances school children methods parents children grades kindergarten fourth grade three public elementary schools completed two retrospective survey questionnaires one assessing children sleep behaviors examining television viewing habits child family sleep domains assessed included bedtime resistance sleep onset delay sleep duration anxiety around sleep parasomnias night wakings daytime sleepiness teachers three schools also completed daytime sleepiness questionnaires sample results television viewing practices examined study associated least one type sleep disturbance despite overall close monitoring television viewing habits one quarter parents reported presence television set child bedroom television viewing habits associated significantly sleep disturbance increased daily television viewing amounts increased television viewing bedtime especially context television set child bedroom sleep domains appeared affected consistently television bedtime resistance sleep onset delay anxiety around sleep followed shortened sleep duration parent threshold defining problem sleep behavior child also important determining significance association sleep disturbance television viewing habits conclusion health care practitioners aware potential negative impact television viewing bedtime parents questioned children television viewing habits part general screening sleep disturbances part anticipatory guidance regards healthy sleep habits children particular presence television set child bedroom may relatively underrecognized important contributor sleep problems school children
reinforced soil composite material elements high tensile resistance implemented increase tensile resistance soil geotextiles one major groups geosynthetic products used soil reinforcement paper deals effects using nonwoven geotextile improve ultimate bearing capacity footings resting sand medium density plate load tests performed using square plates effects depth first layer geotextile vertical spacing well number geotextile layers ultimate bearing capacity footings studied moreover impact plate size sample size examined numerically performing finite element analyses different sizes square plate experimental results showed maximum bearing capacity achieved system four geotextile layers vertical spacing geotextile layers geotextile width width plate numerical analyses indicated increasing size plate values bearing capacity ratio bcr gradually decrease however additional increase size plate little impact bcr values
understanding feedbacks human environmental health critical millions cope recurrent illness rely directly natural resources sustenance although studies examined environmental degradation exacerbates infectious disease effects human health use environment remains unexplored human illness often tacitly assumed reduce human impacts environment logic ill people reduce time effort put extractive livelihoods thereby impact natural resources followed households living lake victoria kenya four time points examine illness influenced fishing using fixed effect conditional logit models control individual level time invariant factors analyzed effect illness fishing effort methods illness among individuals listed fishing primary occupation affected participation fishing however among active fishers found limited evidence illness reduced fishing effort instead ill fishers shifted fishing methods ill fishers likely use methods illegal destructive concentrated inshore areas required less travel energy ill fishers also less likely fish using legal methods physically demanding require travel deep waters considered sustainable altering physical capacity outlook fishers human illness shifted effort engagement natural resources sustainability actions findings show previously unexplored pathway poor human health may negatively impact environment
deployment smart meters promising innovation comes enhance energy efficiency measures smart grid smart meter enables distributors better understand electrical network reduce complexity management operations offers households monitoring control possibilities everyday energy consumption distribution detailed information household consumption evolution involves disaggregation individual household loads term individual energy consumption known non intrusive loads monitoring paper present supervised nilm approach based dynamic fuzzy means events clustering knn label matching first filtering method involved enhance edge events detection step perform dynamic fuzzy means clustering procedures build appliances signature data based active reactive power measurements taking account time day usage data base refined map potential clusters centers best identify different appliances performance evaluation proposed approach conducted showing recognition rate high consumption loads promising results low consumption loads
accident fukushima daiichi nuclear power station march fukushima accident several investigation committees japan issued reports lessons learned accident including recommendations severe accident research review specific severe accident research issues began fukushima accident atomic energy society japan aesj aesj recently developed new thermal hydraulics safety evaluation fundamental technology enhancement strategy roadmap light water reactor safety improvement development fukushima accident thoroughly revising first version roadmap prepared revision made considering lessons learned fukushima accident time research expert committee evaluation severe accident established aesj published phenomena identification ranking tables pirts thermal hydraulics source term issues severe accidents based findings fukushima accident utilizing pirt methodologies present paper reviews severe accident research fukushima accident lessons learned severe accident research fukushima accident severe accident research issues reviewed fukushima accident aesj current severe accident research activities mostly based two mentioned aesj reviews fukushima accident japan
energy efficiency heating ventilating air conditioning hvac system optimized using radial basis function neural network rbfnn combined epsilon constraint method reported new method adopts advanced algorithm rbfnn hvac system estimate residual errors increase control signal reduce error results objective study develop simulate rbfnn self tuning pid controller decoupled bilinear hvac system control temperature relative humidity produced system case study indicates rbfnn algorithm much better accuracy optimization pid pid rbfnn respectively elsevier ltd rights reserved
rhinoviruses common causes common cold many distinct lineages fall major minor groups use different cell surface receptors enter host cells minor group rhinoviruses immunogenic laboratory studies although patterns transmission cold symptoms broadly similar major group present evolutionary evidence minor group viruses also immunogenic humans key finding rates amino acid substitutions exposed sites capsid proteins tend elevated minor group relative major group viruses rates buried sites show consistent differences reanalysis historical virus watch data also indicates higher immunogenicity minor group viruses consistent findings evolutionary rates amino acid positions directly exposed immune surveillance increased immunogenicity speed evolution minor group lineages may contribute large numbers rhinovirus serotypes coexist differing virulence importance colds caused rhinoviruses rvs caused subset known minor group members rhinovirus species correlated inception aggravation asthma risk populations genetically minor group viruses similar major group derived although tend elicit stronger immune responses differences rates patterns molecular evolution highly relevant epidemiology strains show high rates amino acid substitutions capsid proteins exposed sites previously identified immunogenic increase significantly greater minor group viruses findings inform future studies recently discovered also appears exacerbate asthma adults children addition findings draw attention difficult problem explaining long term coexistence many serotypes major minor group rvs
investigation explores relationship verbal non verbal communication coexistence school settings among fourth grade students ages district school data collection methods used participant observation semi structured interview analyzing information recorded shown students identify characteristics verbal non verbal communication link social behavior school thus article acknowledges importance communication coexistence habits learned home together acquired school become patterns guide behavior favors understanding coexistence processes schools
eastern coastal areas china high density population developed society economy large water pollution emissions reduce water pollution realize coordinated development economy environment become national focus effective environmental policies consider regional differences development stage sustainability performance first analyzed water pollution emissions intensity eastern coastal areas china urgency emissions reduction using year environmental statistics characterized development stages eastern coastal areas based relationships water pollution emissions intensity economic development built coordination degree index economic development water environment protection measure sustainability results show water pollution emissions intensity decreases economy grows less developed regions better coordination degree developed regions especially developed ones shanghai show pressures long term sustainability hebei less developed regions take advantage economic growth invest advanced environment protection technologies developed regions need upgrade economic structures municipal infrastructures overall study provided comprehensive approach understand regional difference development stage sustainability performance eastern coastal region china well need different environmental policies reduce water pollution emissions elsevier ltd rights reserved
intensity distribution inhomogeneous interference pattern received ccd processing errors agglutination errors produced researching processing spatial heterodyne spectrometer reduces accuracy transform spectrum inhomogeneous correction method interference pattern proposed analyzing producing mechanism characteristics inhomogeneity existed interference pattern intensity spatial heterodyne spectrometer according method actual interference pattern decomposed monotonously piecewise normalized recombined solve light intensity distribution function transform spectrum convolved fourier transform result reverse light intensity distribution function obtain inhomogenous correction spectrum lastly inverse fourier transform implemented corrected spectrum realize inhomogenous correction interference pattern correction method could used measured monochromatic interference pattern near infrared light spatial heterodyne spectrometer results show method could effectively improve homogeneity interference pattern intensity distribution inhibit edge frequency signal transform spectrum compared simulated ideal spectrum noise spectrum reduces noise spectrum reduces signal noise accuracy spectrum increased
clinical investigations shown significant relationship osteoarthritis estrogens levels menopausal women therefore treatment exogenous estrogens shown decrease risk however effect estrogen clearly demonstrated chondrocytes using phytoestrogens lack specific side effects estrogens may provide alternative therapy study designed examine possible effects phytoestrogen daidzein human chondrocyte phenotype extracellular matrix formation phytoestrogens lack specific side effects estrogens may provide beneficial effect without causing hormone based side effect human chondrocytes cells cultured flask pcl scaffold systems daidzein cytotoxic effect determined mtt assay chondrocyte cellular content glycosaminoglycans gags total collagen chondrogenic gene expression determined culture systems treatment daidzein daidzein showed time dependent dose independent effects chondrocyte bioactivity compound low doses showed significant increase total collagen gags production similar levels culture environment mrna levels collagen sox increased significantly expression levels fibronectin laminin integrin beta significantly increased especially culture system study illustrated potential positive effects daidzein maintenance human chondrocyte phenotype extracellular matrix formation suggesting attractive viable alternative therapy
ethnobotanical relevance pogostemon elsholtzioides benth lamiaceae aromatic shrub endemic eastern himalaya region leaves used treating goiter high blood pressure indigenous people arunachal pradesh india young leaves used vegetable leaf decoction also used cough cold headache indigenous communities northeast india aim study species used treating hypertension genus pogostemon rich essential oil therefore present study aimed investigation chemical constituents vasorelaxant cardiovascular effects essential oil elsholtzioides materials methods elsholtzioides collected pasighat arunachal pradesh india essential oil extracted shade dried leaves essential oil analyzed fid volatile constituents identified vasorelaxant cardiovascular properties essential oil studied phenylephrine induced contraction isolated endothelium intact aortic preparations measuring systolic diastolic mean arterial pressure map heart rate carotid artery cannulation wistar rats results essential oil rich sesquiterpenes curzerene benzophenone alpha cadinol germacrone major constituents essential oil exhibited significant vasodilation effect phenylephrine induced contracted aortic rings vasorelaxant effect essential oil also observed presence absence nitro arginine methyl ester phenylephrine contracted aortic rings also induced reduction systolic diastolic map conclusions essential oil elsholtzioides exhibited significant vasorelaxant effect endothelium intact aortic preparation mediated nitric oxide dependent pathway also reduced however study needed screen role calcium ions intracellular extracellular pathway
global optimisation unknown noisy functions daunting task appears domains ranging games control problems meta parameter optimisation machine learning show incorporate heuristics stochastic simultaneous optimistic optimization stosoo global optimisation algorithm weak requirements function case heuristics come form covariance matrix adaptation evolution strategy cma new algorithm termed guided stosoo stosoo combines ability cma fast local convergence due algorithm following natural gradient global optimisation abilities stosoo compare three algorithms harder parts comparing continuous optimisers black box optimization benchmarking benchmark suite provides default set functions testing show approach keeps best worlds almost optimal exploration exploitation stosoo local optimisation strength cma
objective determine type number injuries occur training practice muay thai kick boxing compare data obtained previous studies karate taekwondo methods one one interviews using standard questionnaire injuries incurred training practice muay thai kick boxing conducted various gyms competitions united kingdom muay thai gala holland results total people questioned men women beginners amateurs professionals injuries lower extremities common groups head injuries second common professionals amateurs trunk injuries next common beginners difference injury distribution among three groups significant less equal soft tissue trauma common type injury three groups fractures second common professionals amateurs beginners sprains strains less equal annual injury rates beginners participants amateurs participants professionals participants beginners injuries resulted seven days training amateurs professionals values respectively conclusions results similar found karate taekwondo regard injury distribution type rate percentage injuries resulting time training less
background interstitial pneumonia autoimmune features ipaf recently defined international taskforce characterize interstitial lung disease associated systemic manifestations limited subtle serological clinical autoimmune abnormalities fulfilling international criteria diagnosis given connective tissue disease objective report series patients ipaf compare outcome cohort patients idiopathic pulmonary fibrosis ipf methods retrospective analysis consecutive patients single institution year period results consecutive patients interstitial lung disease idiopathic interstitial pneumonia including ipf connective tissue disease ipaf patients females mean fvc mean dlco serologic criteria ipaf frequent followed morphologic criteria clinical criteria fifty three percent patients nsip pattern nailfold capillaroscopy found giant capillaries patients tested significant found overall survival patients ipaf ipf conclusion recently defined criteria ipaf fulfilled significant proportion patients referred interstitial lung disease compared ipf patients ipaf frequently females distinctive characteristics relatively frequent abnormalities nailfold capillaroscopy difference age overall survival prospective studies needed guide management ipaf elsevier ltd rights reserved
article authored patient living obesity obesity medicine specialist reviews patient successfully lost maintained loss decade achieved primarily behavioral intervention including support visits structured food plan changes physical activity undergo bariatric surgery majority time treated anti obesity medication article review patient lost weight kept particularly relationship importance decreasing sedentary time
mutations jak calr observed patients myeloproliferative neoplasms mpn get insight dynamics mutant clone assessed mutant allele burden hematopoietic stem cells hscs hematopoietic progenitor cells hpcs granulocytes patients polycythemia vera essential thrombocythemia myelofibrosis calr mutated patients harbored higher mutant load progenitor level jakvf positive hscs hpcs moreover hscs calr mutated patients showed similar mutational load patients calr mutated regarding jakvf mpn patients showed low mutational burden progenitor level whereas myelofibrotic phase dominance mutated clone constant finding conclusion size mutated clone chronic phase mpn different according genotype calr mutated showing pattern similar observed elsevier ltd rights reserved
false memory claimed result associative process generalisation well representative memory errors occur stage memory encoding consolidation retrieval albeit varied mechanisms aim paper experimentally determine cognitive dysfunction brought sleep loss time stimulus encoding influence false memory production whether relationship holds across sensory modalities subjects undertook deese roedigger mcdermott drm false memory task visual task designed produce false memories performance measured subjects well rested time bed tib subjects either sleep restricted tib nights sleep deprived total results indicate partial total sleep loss produced equivalent effects terms false veridical verbal memory subjects performed worse sleep loss regardless whether partial total sleep loss cued recognition based false veridical verbal memory tasks sleep loss interfered subjects ability recall veridical false memories free recall conditions effects sleep loss visual false memory task argued represent dysfunction slow repair online verbal associative process brain following inadequate sleep elsevier inc rights reserved
dynamic response bearing load speed often determine performance limitations machines necessary able predict bearing dynamic performance integral part machine design analysis paper mathematical model developed investigate nonlinear dynamic behavior rotor bearing system due localized defects inner race outer race mathematical formulation contacts rolling elements inner outer race considered nonlinear springs whose stiffness obtaining using hertz contact stress theory nonlinear damping also taken consideration cylindrical roller bearing governing equations motion formulated using energy approach contact force contact stiffness nonlinearity calculated using newton raphson method unknown nonlinear simultaneous equation new mark implicit integration technique coupled newton raphson method solve differential equations computer program developed simulate defect inner race outer race results represented time frequency domain equations motions solved using newmark beta method phase plot poincare map proposed mathematical model also compared experimental results radial axial load condition results obtained predicted model frequency spectrum phase plot various speeds mathematical modeling experimental results found quite similar
fucoidan sulfated marine polysaccharide many potential biological functions including anticancer activity recently fucoidan reported target selectin expressed metastatic cancer cells increasing research attention devoted developments fucoidan based nanomedicine however application traditional chitosan fucoidan nanoparticles anticancer drug delivery may limited due deprotonation chitosan greater study mutlistimuli responsive nanoparticle self assembled fucoidan cationic polypeptide protamine developed enzyme responsive properties characterized circular dichroism spectroscopy dynamic light scattering dls zeta potential analysis enzymatic digestion acidic intracellular microenvironment cancer cells triggered release anticancer drug doxorubicin nanoparticles protamine fucoidan complex nanoparticles selectin mediated endocytosis charge conversion stimuli tunable release properties showed improved inhibitory effect metastatic breast cancer cell line mda elsevier ltd rights reserved
nanotechnology key century involving aspects nanoscale science technology generating paradigm shift diverse areas physics chemistry electronics materials engineering even medicine biology result interdisciplinary nature terahertz electronics among fastest growing areas result discovery fabrication investigation nanomaterials particular carbon nanotubes graphenes compound semiconductors advances nanotechnology led development nano terahertz devices capable transcending conventional devices compactness efficiency performance operating frequency paper sets evolution nanotechnology terahertz electronics challenge awaits microwave science engineering research community
purpose study investigate acute effect active lower limb stretching routine sports related training load hamstring eccentric length tension relationship recreational sportsmen completed three assessment sessions initial familiarization session two experimental sessions control stretching random order immediately interventions stretching control eccentric isokinetic peak torque maximum force angle total work measured prone position alteration eccentric length tension relationship could used primary risk factor hamstring muscle strains findings present study tentatively suggest static stretching would able alter relative risk hamstring muscles
problem whether seasonal decomposition used prior aggregation time series quite old tackle problem using state space representation variance covariance structure simplified one component model variances estimated components two series system compared direct indirect approaches also multivariate method covariance structure two time series important relative efficiency indirect estimation always best series independent series measurement errors negatively correlated direct estimation may much better sense covariance structures indicate direct estimation used others indicate indirect approach efficient signal noise ratios relative variances used inference
great number pipelines china unsatisfactory condition faced problems corrosion cracking approaches underwater pipeline detection pipeline detection autonomous underwater vehicle pdauv hereby designed solve problems working advanced optical acoustical electrical sensors underwater pipeline detection pdauv test bed examines logical rationality program effectiveness hardware architecture accuracy software interface protocol well reliability stability control system also verifies effectiveness control system tank experiments sea trials motion control system pdauv including hardware software architectures introduced work software module information flow motion control system pdauv novel neural network based control nnc also covered besides real time identification method based neural network used realize system identification tank experiments sea trials carried verify feasibility capability pdauv control system complete underwater pipeline detection task
lipopolysaccharide lps induces visceral hypersensitivity corticotropin releasing factor crf also modulates visceral sensation besides lps increases crf immunoreactivity rat colon raises possibility existence link lps crf system modulating visceral sensation present study tried clarify possibility visceral sensation assessed abdominal muscle contractions induced colonic balloon distention visceromotor response electrophysiologically conscious rats threshold visceromotor response measured administration drugs lps dose subcutaneously decreased threshold administration intraperitoneal administration anakinra interleukin receptor antagonist interleukin antibody blocked effect additionally beta induced visceral allodynia astressin non selective crf receptor antagonist abolished effect lps astressin crf receptor type crf antagonist alter peripheral crf receptor type crf stimulation cortagine exaggerated effect lps activation crf urocortin abolished lps induced visceral allodynia possibly stimulating release addition effect mediated peripheral crf signaling since lps cytokine system thought contribute altered visceral sensation patients irritable bowel syndrome results may suggest crf plays crucial role pathophysiology disease
informed social interactional framework stress parenting aim study examine mediating effect depression symptoms association parents marital status married divorced parents child physical abuse potential portuguese community sample hypothesized possible observed differences divorced married parents child physical abuse potential would explained depression symptoms parents assessed marital status severity depression symptoms child physical abuse potential results showed compared married parents divorced parents higher child physical abuse potential however parents depression symptomatology found mediator effect marital status differences child physical abuse potential influence status divorced parents increase child physical abuse potential explained increase parents depression symptoms finding suggested parents divorced status longer effect child physical abuse potential parents depression symptomatology tested mediator variable present mediation model explained variability child physical abuse potential score practical implications findings prevention psychological intervention also discussed
singular value decomposition svd effective signal denoising tool attracting considerable attention recent years basic idea behind svd denoising preserve singular components scs significant singular values however shown singular values mainly reflect energy decomposed scs therefore traditional svd denoising approaches essentially energy based tend highlight high energy regular components measured signal ignoring weak feature caused early fault overcome issue reweighted singular value decomposition rsvd strategy proposed signal denoising weak feature enhancement work novel information index called periodic modulation intensity introduced quantify diagnostic information mechanical signal index decomposed scs evaluated sorted according information levels rather energy based truncated linear weighting function proposed control contribution reconstruction denoised signal way weak informative scs could highlighted effectively advantages rsvd traditional approaches demonstrated simulated signals real vibration acoustic data two stage gearbox well train bearings results demonstrate proposed method successfully extract weak fault feature even presence heavy noise ambient interferences elsevier ltd rights reserved
background peanuts common food provoke fatal near fatal anaphylactic reactions treatment anti hige mab efficacious requires frequent parenteral administration objective based knowledge peanut allergy mediated peanut specific ige hypothesized single administration adeno associated virus aav gene transfer vector encoding anti hige would protect repeated peanut exposure host peanut allergy methods developed novel humanized murine model peanut allergy recapitulates human anaphylactic response peanuts nod scid ilrgamma null mice transferred blood mononuclear cells donors peanut allergy sensitized peanut extract therapy constructed adeno associated serotype vector coding full length high affinity anti hige antibody derived fab fragment anti hige mab omalizumab aavrh anti hige reconstituted mice peanut specific ige induced peanut sensitization hypersensitivity reactions provoked feeding peanuts mice symptoms similar human subjects peanut allergy results single administration aavrh anti hige vector expressed persistent levels anti hige anti hige vector administered either sensitization peanut sensitization manifestation peanut induced phenotype blocked ige mediated alterations peanut induced histamine release anaphylaxis scores locomotor activity free ige levels protected animals death caused anaphylaxis conclusion degree persistent efficacy translates human subjects aavrh anti hige could effective time preventative therapy peanut allergy possibly severe ige mediated allergies
background smoking leading cause preventable death early studies based samples twins linked lifetime smoking practices genetic predisposition flavin containing monooxygenase fmo protein family consists group enzymes metabolize drugs xenobiotics fmo fmo potentially susceptible genes nicotine metabolism process methods study investigated potential fmo genes confer risk nicotine dependence via deep targeted sequencing study subjects comprising nicotine dependents controls european american african american specifically focused two genomic segments including fmo fmo pseudo gene fmop aimed investigate potential association fmo genes nicotine dependence common low frequency rare variants analyzed using different algorithms potential functional significance snps association signal investigated relevant bioinformatics tools results identified different clusters significant common variants european significant snp maf fmo african americans significant snp maf fmop significant signals identified haplotype based analyses gene network investigation indicated fmo fmo strong relation variety genes belonging cyp gene families combined score greater significant variants identified snps located within intron regions unknown functional significance indicating need future work understand underlying functional significance signals conclusions findings indicated significant association fmo genes nicotine dependence replications findings ethnic groups needed future significant variants identified snps located within intronic regions unknown functional significance indicating need future work understand underlying functional significance signals
paper presents modeling design analysis bidirectional half bridge converter suitable power electronic interface main energy storage system electric traction drive hybrid electric vehicles hybrid energy storage system composed battery unit ultracapacitor pack considered parallel linked multi input converter half bridge bidirectional cell topology chosen link battery ultracapacitor storage unit link paper focuses modeling proposed converter dynamic steady state analysis averaging linearization techniques applied obtain averaged state space models small signal models converter boost buck operation modes criterion sizing converter passive components based imposed design specifications constraints illustrated simulation results buck boost converter normal functioning faulty conditions presented particular short circuit faults open circuit faults diodes transistors analyzed
paper presents substantially simplified axiomatization map theory proves consistency axiomatization called zfc assumption exists inaccessible ordinal map theory axiomatizes lambda calculus plus hilbert epsilon operator theorems zfc set theory including axiom foundation provable map theory one omits hilbert epsilon operator map theory one left computer programming language map theory fulfills church original aim lambda calculus map theory suited reasoning classical mathematics well computer programs furthermore map theory suited eliminating barrier classical mathematics computer science rather supporting two fields side side map theory axiomatizes universe maps wellfounded class wellfounded maps map theory corresponds universe sets zfc first axiomatization map theory axioms populated class wellfounded maps much like power set axiom along others populate universe zfc new axiomatization map theory synthetic sense class wellfounded maps defined inside map theory rather introduced axioms paper define notions canonical non canonical kappa kappa sigma expansions prove smallest strongly inaccessible ordinal canonical kappa sigma expansions models proves consistency furthermore appendix prove canonical expansions fully abstract models computational part map theory elsevier rights reserved
electricity generators varying capacities popularly utilized nigeria alternative source power owing unreliability electricity supply national grid study evaluated impact emissions generating sets air quality human health selected areas abeokuta city nigeria levels particulates carbon monoxide carbon dioxide sulphur oxides nitrogen oxides nitrogen dioxide hydrogen sulphide methane monitored using portable samplers copies questionnaire administered generator operators nearby residents collect additional information capacities sampled generators ranged kva range mean concentrations carbon dioxide methane ppm carbon monoxide ppm nox ppm methane ppm sulphur oxides ppm hydrogen sulphide ppm highest generator sites distance sample sites generator locations accounted variation pollutants levels ailments frequently suffered exposed residents included nasal congestion cough headache fever national policy appropriate use electricity generator urgently needed nigeria
objective physical inactivity increases postmenopausal possibly premenopausal breast cancer risk although different biologic mechanisms proposed primary objective estimate breast cancer risk associated high versus low levels moderate vigorous recreational activity separately premenopausal postmenopausal women methods conducted systematic review literature published july included reports cohort case control studies relating moderate vigorous recreational physical activity metabolic equivalent breast cancer incidence exclusively premenopausal postmenopausal women appraised study quality performed meta analyses using random effects modeling subgroup meta analyses based tumor subtype race body mass index parity hormone therapy use family history cancer statistical adjustment body fatness dose response relations examined results pooled relative risks rrs women higher versus lower levels moderate vigorous recreational activity premenopausal studies postmenopausal studies breast cancer respectively high heterogeneity inverse associations weaker among postmenopausal cohort studies studies statistically adjusted nonrecreational occupational household activity premenopausal postmenopausal risk estimates versus without body fatness adjustment vary menopause status although subgroup effects menopause dependent among studies overweight obese women inverse association postmenopausal premenopausal breast cancer respectively dose response curves generally nonlinear conclusions although risk estimates may similar premenopausal postmenopausal breast cancer subgroup effects may menopause dependent
simulation major impact advancement healthcare team training assessment date simulation based training assessments focus teamwork behaviors impact team performance often ignoring critical cognitive motivational affective team processes evidence team science research demonstrates strong relationship team cognition team performance suggests role simulation development team level construct article synthesize research broader team science literature provide foundational knowledge regarding team cognition highlight best practices using simulation target team cognition
purpose spite benefits virtual models building construction industry full potential models especially construction operation phases remains largely unrealized increasing developments information communication technology number attempts made extend use models development integration approaches technologies however issue integrating virtual model physical construction enable directional coordination adequately addressed thus purpose paper investigate application cyber physical systems cps approach enhancing directional coordination virtual models physical construction design methodology approach research employs scenario development rapid prototyping illustrate cps integration construction industry particular focus facilitating directional coordination proof concept prototype systems developed validated using focus group consisting industry practitioners findings directional coordination virtual models physical construction potential improve real time progress monitoring control construction process tracking changes model updates information exchange design office job site real time documentation built status high value components improved sustainability practices originality value paper adds value construction industry demonstrating application cps approach enhancing directional coordination virtual models physical construction development system architectures scenarios prototype systems
background objective study pregnancy outcomes groups danish women pregnancy ending according exposure montelukast methods cross sectional observational study danish women selecting live births stillbirths birth registry spontaneous abortions induced terminations patient registry montelukast exposure obtained prescription registry atc code rdc exposure period months last menstrual period end first trimester four groups studied women prescription montelukast women prescription montelukast anti asthmatic medications women prescription anti asthmatic medications women without prescription anti asthmatic medications results total singleton pregnancies weeks identified pregnancies group pregnancies group group group risk preterm birth maternal preeclampsia gestational diabetes increased pregnancies exposed montelukast significant differences found risk major congenital anomalies adjusted odds ratio group group conclusion pregnant women prescriptions montelukast higher risk preterm birth maternal complications risks known associated maternal asthma increased risk found analysis including exposed pregnancies needed determine risk specific wiley periodicals inc
raloxifene selective estrogen receptor modulator used extensively osteoporosis addition effect osteoporosis treatment emerging evidences show raloxifene affects vascular function different tissues cirrhosis characterized portal hypertension complicated hepatic encephalopathy portal hypertension affects portal systemic shunt leads hepatic encephalopathy vascular modulation might influence severity hepatic encephalopathy herein evaluated impact raloxifene bile duct ligation bdl induced cirrhotic rats female sprague dawley rats received bdl plus ovariectomy sham operation four weeks later rats divided subgroups respectively receive raloxifene day saline vehicle days day motor activities hemodynamic parameters measured hepatic vascular mrna protein expressions determined histopathological change liver examined found liver biochemistry ammonia level motor activity similar cirrhotic rats without raloxifene administration hemodynamic parameters significantly different except raloxifene reduced portal venous inflow raloxifene exacerbated hepatic fibrosis regulated hepatic endothelin cyclooxygenase protein expressions addition raloxifene modulated mrna expressions endothelial nitric oxide synthase cyclooxygenase endothelin superior mesenteric artery collateral vessel conclusion raloxifene aggravates hepatic fibrosis decreases portal venous inflow cirrhotic rats without adversely affecting portal hypertension hepatic encephalopathy modulation hepatic vascular endothelin endothelial nitric oxide synthase cyclooxygenase expressions may play role mechanism
assessment structural potentially economic factors determining cost treatment type inpatient mortality traumatic hip fractures important health policy issues showed insurance status treatment university hospitals significantly associated treatment type primary hip replacement cost lower inpatient mortality respectively introduction purpose study determine influence structural level hospital care patient insurance type treatment hospitalization cost inpatient mortality cases traumatic hip fractures switzerland methods swiss national medical statistic screened adults hip fracture primary diagnosis gender age insurance type year discharge hospital infrastructure level length stay case weight reason discharge coded diagnoses procedures extracted descriptive statistics multivariate logistic regression treatment primary hip replacement well inpatient mortality dependent variables performed results obtained inpatient case records medical statistic hospitalization costs calculated second dataset swiss national cost statistic cases hip fractures discharged average inpatient costs per case highest discharges university hospitals lowest basic coverage hospitals controlling variables higher costs hip fracture treatment university hospitals significant inmultivariate regression university hospitals lower inpatient mortality rate full basic care providers results confirmed multivariate logistic regression analysis odds ratio confidence interval full basic coverage hospitals university hospitals respectively proportion privately insured varied university hospitals specialized hospitals private insurance predicting treatment hip fracture primary hip replacement conclusion seeming importance insurance type hip fracture treatment large inequity distribution privately insured provider types would worth closer look regulatory authorities better outcomes lower mortality rates hip fracture treatment hospitals higher structural care level advocate centralization care
goal article bridge difference theoretical practical approaches answering queries databases nulls theoretical research long ago identified notion correctness query answering incomplete data one needs find certain answers true regardless incomplete information interpreted serves notion correctness query answering carries huge complexity tag practice hand query answering must efficient achieve sql uses three valued logic evaluating queries databases nulls due complexity mismatch two approaches coincide perhaps related way instance sql always produce answers certain sql certain answers semantics could totally unrelated show however slight modification three valued semantics relational calculus queries provide required certainty guarantees key point new scheme fully utilize three valued semantics classify answers certain noncertain done rather certainly true certainly false unknown yields relatively small changes evaluation procedure consider level declarative relational calculus procedural relational algebra queries new evaluation procedures give certainty guarantees even queries returning tuples null values
background health parents disabilities well understood existing research used small non representative samples lack research using national representative data hindered advocacy policy making efforts objective present study used nationally representative data examine prevalence rates chronic physical health conditions among parents disabilities compared parents without disabilities methods analyzed pooled linked data medical expenditure panel survey corresponding national health interview survey conducted logistic regression analyses examine age adjusted health differences parents without disabilities controlling covariates outcome measures included obesity arthritis asthma cancer heart disease diabetes emphysema high cholesterol hypertension stroke results controlling model covariates adjusting age parents disabilities significantly higher odds aor ranging chronic conditions parents disabilities also significant higher odds conditions aor conditions aor conditions aor conclusions parents disabilities significantly poorer health parents without disabilities elsevier inc rights reserved
study perceptual encryption algorithm proposed avc video enhance scrambling effect encryption space six new scan orders designed avc encoder analysing energy distribution discrete cosine transform coefficients proven similar performance conventional zigzag scan order symmetrical scan order six new scan orders combined two existing scan orders design scan order based perceptual encryption algorithm specifically video encryption achieved specifically randomly selecting one scan order eight scan orders security key sign bit flipping coefficients also incorporated increase encryption space experimental results show proposed approach advantages low bitrate increase low computational cost furthermore flexible stronger security existing scan order based video encryption schemes
background influence violent video games behavior subject heated debate based conflicting scientific data since arrival increasingly violent video games media coverage attracted several mass killings columbine virginia tech utoya aurora emotional debate developed concerning impact video games aggressiveness violence even criminality several recent meta analyses contributed contradictory findings whereas respect use video games studies conclude increase aggressiveness short long term others revealed decrease criminality findings previous studies overwhelmingly favor negative influence aggressiveness however data impact type media criminal behavior lacking objective work aims bring new arguments corroborate invalidate assumption use violent video games criminogenic risk factor method conducted case control study comparing use violent video games sample subjects investigation versus sample general population characterizing consumption patterns video games looked association criminal act exposure violent video games univariate multivariate analysis conducted results proportion players subjects investigation including consumers violent video games lower observed control subjects addition find significant difference consumption patterns violent video games criminal population control population finally estimated relative risk criminal enactment associated use video games significant multivariate analysis taking account association already known criminogenic risk factors find significant excess risk associated use violent video games discussion results consistent current literature many studies suggest despite increase aggressiveness violence video games could cause reduction criminality concerns effects violent video games aggressive thought patterns emotions behavior justified study able show exposure violent digital games associated increase criminality aggressiveness violent behavior nevertheless paradoxical results incompatible indeed tremendous difference aggressiveness hetero aggressive outburst likely answer lies complexity concept committing act exposure violent video games could one factor among many others constellation parameters leading individual commit aggressive act research hot topic still inconsistent thus psychiatrist may wish careful public statements linking violent digital games harm psychiatrists medical professionals researchers would risk damaging credibility exaggerating video game violence effects indeed lack scientific data dealing relationship violent video games interaction individual mental state aggressive outcome conclusion results study favor accountability violent video games criminal act conclusion leans consider use criminogenic risk factor results discussed light current literature elsevier masson sas rights reserved
affordable portable indirect impedance measurement techniques minimum hardware post processing requirements necessary various applications particular bioimpedance measurements paper new method extract single dispersion cole bioimpedance model parameters presented using simple circuit consisting operational amplifier set resistors examine theory behind magnitude method demonstrate application extraction impedance data number different fruit samples three means compute single dispersion cole model parameters given discussed different measurement scenarios compared experimental results elsevier rights reserved
goal target controlled infusion anesthesia closed loop automated drug delivery method computer aided control goal design test automated drug infusion platform propofol delivery total intravenous anesthesia tiva administration methods proposed method dilution chamber first order exponential decay characteristics used model pharmacodynamics decay drug dilution chamber connected flow system electrochemical cell containing organic film coated glassy carbon electrode working electrode set feedback controlled delivery platform optimize parameters ferrocenemethanol used proxy propofol output signal sensor connected controller prompted syringe pump feedback controlled drug infusion results result bench top drug infusion platform automate delivery propofol based measurement concentration organic film coated voltammetric sensor conclusion evaluate performance characteristics infusion platform propofol concentration dilution chamber monitored organic film coated glassy carbon electrode difference set measured concentrations assessed feasibility measurement based feedback controlled propofol delivery demonstrated confirmed significance platform contribute high performance tiva application intravenous propofol anesthesia
aimsthe aim study identify distinctive foundations care culture nurse leaders manage strengthen quest ethically sustainable caring cultures backgroundsustainability presupposes ethical leadership management good care well educated staff research nls managers ethically sustainable caring cultures available designthe study quantitative design elements qualitative research approach methoddata collected web based questionnaire sent staff eight selected units hospital western finland september reply rate data material comprised opinion questions ranking values two open ended questions lodestars care ethical principles care work resultsnls manage care culture rests solid foundation staff creators ethically sustainable caring culture includes good traditions praxis care nls managers therefore responsible realizing passing ethically sustainable caring cultures creating prerequisites staff growth development conclusionthe basis good care patient safety sustainability comprised ethics respectful dignified care evidence based economically stable management nls responsibility nurture protect core caring create contextual professional cultural prerequisites maintain core art caring well care staff ethical professional competence
salient object detection important issue computer vision image procession facilitate humans locate conspicuous visual regions complex scenes rapidly improve performance object detection video tracking recent years low rank matrix approximation proved favorable image saliency detection gained great deal attention underlying assumption low rank recovery image combination background regions low rank salient objects sparse corresponds tough non smooth optimization problems paper incorporating norm minimization obtain corresponding smooth optimization problems propose two effective algorithms proved convergence guarantee robustness proposed methods input image divided patches patch approximately represented mean value besides multi scale visual features patch given image extracted capture common low level features color edge shape texture salient objects given image indicated sparse coefficients solved low rank matrix approximation problem saliency maps produced integration high level prior knowledge finally extensive experiments four real world datasets demonstrate proposed methods come competitive performance eight compared state arts elsevier rights reserved
prevalence skull fractures mild head trauma children ages children younger years current standard management child diagnosed isolated skull fracture isf institute hospitalization observation period based data literature less minor head injuries require neurosurgical intervention main objective study evaluate risk neurological deterioration isf cases order assess need hospitalization reviewed medical charts children hospitalized isf glascow coma scale time arrival collected data regarding demographic characteristics mechanism injury fracture location clinical symptoms signs need hospitalization need repeated imaging data collected three time points presentation emergency room hospitalization month admission patients parents asked course month following discharge none children included study needed neurosurgical intervention asymptomatic month injury two children underwent repeated head due persistence worsening symptoms scans reveal new findings lead intervention whatsoever children arriving emergency room minor head injury isolated skull fracture imaging studies may considered discharge short period observation discharge considered cases provided child reliable social environment responsible caregivers able return hospital necessary hospital admission reserved children neurologic deficits persistent symptoms suspected child abuse parent unreliable unable return hospital necessary reducing unnecessary hospitalizations prevent emotional stress addition saving costs child family health care system
objective local estrogens used treatment genitourinary symptoms menopause efficacy adverse effects estrogen containing vaginal tablets estrogen containing vaginal creams gels comparable objective assess compliance adherence treatment large population methods retrospective study women aged performed central district clalit health services demographic data women usage details electronically recorded patients eligible analysis used least consecutive months results total patients used continuous monotherapy patients received treatment received treatment sixty four percent women treated treated least months compared women administered months treatment women asked another prescription compared women mean duration treatment days treated women days treated group conclusions present study showed superiority compliance adherence postmenopausal women treatment estrogen tablets estrogen gel
chronic diseases arise mutual reinforcement pathophysiological processes cause aberrant steady state sequence events may underlie chronic constipation associated dysbiosis gut study hypothesized assemblage microbial communities directed slow gastrointestinal transit affects host function way reinforces constipation maintains selection microbial communities study used two models opioid induced constipation model mice humanized mouse model germ free mice colonized stool patient constipation predominant irritable bowel syndrome ibs humans examined impact pharmacologically loperamide induced constipation pic ibs structural functional profile gut microbiota germ free mice colonized microbiota pic donor mice ibs patients determine microbiota affects host pic ibs promoted changes gut microbiota characterized increased relative abundance bacteroides ovatus parabacteroides distasonis models pic mice exhibited decreased luminal concentrations butyrate cecum altered metabolic profiles gut microbiota colonization mice pic associated mice cecal human ibs fecal microbiota significantly increased transit time compared control microbiota recipients ibs associated gut microbiota also impacted colonic contractile properties findings support concept constipation characterized disease associated steady states caused reinforcement pathophysiological factors host microbe interactions
magnetic field applied type superconductors ybacuo delta ybco flux quanta penetrate material regular array vortices however transport currents applied act move vortices thus lowers critical current density well destroying superconductivity development microstructures made ybco materials enabled engineers increase critical current density within type materials introducing flux pinning centres material microstnicture flux pinning properties ybacuo delta system varying levels nano perovskite ceramic insulator ybahfo addition studied detail orthorhombic ybacuo delta powder prepared conventional solid state route modified combustion method used synthesizing nanocrystalline ybahfo structure microstnicture samples examined ray diffraction scanning electron microscopy showed ybahfo ybco remained unreacted even higher processing temperature without deteriorating superconducting properties scanning electron microscope image shows yba hfo forms electrical network grains observations suggest yba hfo addition compounds improve electrical connection superconducting grains substantial improvements relative electrical transport properties composites variation sintering temperature density critical transition temperature magnetic field dependence critical current density ybacuo different proportions ybahfo matrix also studied detail found addition elements considerably enhances flux pinning strength system also increase critical temperature critical current density optimum value concentration addition nano ybahfo enhancement critical current density ybacuo delta ybahfo samples attributed sustained formation insulating non reacting ybahf phase acting pinning center addition ybahfo ybacuo delta bulk superconductor also enhances pinning force density
strain provides information local behavior structural components one concerned parameters structural health monitoring shm civil structures plays important role condition assessment bridges terms fatigue yielding structural material safety reserve reliability structural components etc wind structural health monitoring system washms deployed suspension tsing bridge tmb hong kong hitherto operated continuously years part washms strain gauges installed bridge measure dynamic strain response tmb based strain measurement data acquired structural condition tmb evaluated addressing following issues evaluation characteristics stress responses structural members different deck cross sections comparison results obtained statistical analysis daily maximum stresses different members comparison design values designated stresses due live loads serviceability limit state sls ultimate limit state uls evaluation inner forces monitored structural members corresponding strength utilization factors sufs assessment results obtained present study used reference guideline scheduling bridge inspection maintenance activities
background managed care increasingly prevalent health care finance delivery important ascertain effects health care quality relative fee service plans stakeholders concerned basing gatekeeping provider selection utilization management cost may lower quality care date research topic inconclusive largely variation research methods covariates patient age consistently evaluated outcome predictor study provides comprehensive assessment association managed care inpatient mortality medicare privately insured patients methods cross sectional design used examine association managed care inpatient mortality four common inpatient conditions data healthcare cost utilization project state inpatient databases states linked data american hospital association annual survey database hospital discharges categorized managed care fee service phased approach multivariate logistic modeling examined likelihood inpatient mortality adjusting individual patient hospital characteristics county fixed effects results results showed different effects managed care medicare privately insured patients privately insured patients managed care advantage fee service counterparts inpatient mortality acute myocardial infarction stroke pneumonia congestive heart failure advantage found medicare managed care population extent study showed protective effect privately insured managed care driven individuals aged years older consistently better outcomes non managed care counterparts conclusions privately insured patients managed care plans especially older adults better outcomes fee service plans patients medicare managed care outcomes similar medicare ffs additional research needed understand role patient selection hospital quality differences among county populations decreased odds inpatient mortality among patients private managed care determine result hold medicare
energy efficiency mandatory requirement integral part green sustainable buildings energy efficient design optimization design philosophy practical technique proposed used architects professionals several decades especially past years review set selection criteria proposed works identified core literature taking perspective architects analysis conducted core literature reveal state art building energy efficient design optimization analyzed subjects include general procedure origin development classification design objectives variables energy simulation engines optimization algorithms applications review findings confirm building energy efficient design optimization promising technique design buildings higher energy efficiency better overall performance however obstacles still exist future research needed elsevier ltd rights reserved
traffic classification mapping traffic network applications important variety networking security issues network measurement network monitoring well detection malware activities paper propose securitas network trace based protocol identification system exploits semantic information protocol message formats securitas requires prior knowledge protocol specifications deeming protocol language two processes approach based upon new insight grams protocol traces like natural languages exhibit highly skewed frequency rank distribution leveraged context protocol identification securitas first extract statistical protocol message formats clustering grams semantics use corresponding statistical formats classify raw network traces tool involves following key features applicable connection oriented protocols connection less protocols suitable text binary protocols need assemble packets tcp udp flows effective long live flows short live flows implement securitas conduct extensive evaluations real world network traces containing textual binary protocols experimental results bittorrent cifs smb dns ftp pplive sip smtp traces show securitas ability accurately identify network traces target application protocol average recall average precision experimental results prove securitas robust system meanwhile displaying competitive performance practice
heterogeneous wireless sensor networks usually comprised large number inexpensive sensor nodes sample important data deployment position transmit affiliated base stations cooperative manner hierarchical topology control clustering technique suela networks effectively use limited resources sensor nodes prolong network lifetimes however classical clustering techniques topology controlling technique data routing design usually implemented separating two closely correlated counterparts two independent processes result although considerations effectively simplify algorithm design often optimal solutions improving network performances maximizing network lifetimes optimizing data rate link network components base station sensor nodes different features paper proposes unified resolution incorporates considerations overall decision planning procedure evolution decision planning procedure analyzed via detailed examples simulated real environment experimentation shows joint design approach excellent overall deployment allocation member nodes cluster heads close optimal solution
purpose aim study provide first formal evaluation unique session group therapy programme developed based national association people abused children napac method therapy outcomes programme assessed using core tool clients comprised individuals males females age range mean clients survivors sexual physical emotional neglectful childhood abuse combination four different locations london bury belfast prison findings across core domains improvements shown pre post therapy gender age differences revealed improvements shown across community members prison inmates implications person centred approach group therapy beneficial wide range adult clients within community prison settings require therapy historical sexual physical emotional neglectful childhood abuse
primate prefrontal cortex represents past future goals investigate role representing goals agents designed nonmatch goal task involved human monkey interaction trial potential goal objects presented randomly left right part display screen monkey human task choose one match object goal previously chosen human monkey trials intermixed agent acting observer required monitor actor choice switch object goal choice case became actor subsequent trial found neurons encoding actor either monkey human neurons encoding agent future goal position neurons encoding agent previous goal position category neurons encoding human future goal differentiated encoding future goal agents encoding human agent future goal first one might represent covert mental simulation human trials one could represent prediction signal agent choice
well known performance portland cement concrete pcc pavement depends great extent support condition slab texas department transportation txdot recognized importance support condition requires use stabilized base either hot mix asphalt layer minimum asphalt concrete cement stabilized layer pavement design purposes mpa used default value modulus subgrade reaction value support provided bases use single value mpa value rigid pavement design partly insensitivity required slab thickness modulus subgrade reaction current txdot rigid pavement design procedure improve rigid pavement design txdot developed new design procedure continuously reinforced concrete pavement crcp basis mechanistic empirical principles plans implement procedure design procedure slab support rather substantial effects required slab thickness current txdot design procedure increase reliability new pavement design procedure accurate evaluations value important test section constructed various base types used number field tests conducted estimate range values support systems currently used expected utilized including placement nonwoven geotextile lieu asphalt layer current practice using one default value mpa needs revised use nonwoven geotextile recommended evaluations prove viability american society civil engineers
joint injury causes post traumatic osteoarthritis ptoa approximate patients rupturing anterior cruciate ligament acl develop ptoa within decades injury yet mechanisms responsible development ptoa joint injury well understood study examined whole joint gene expression rna sequencing rnaseq day weeks post injury non invasive tibial compression overload mouse model ptoa mimics acl rupture humans identified genes differentially regulated injured contralateral joints includes known regulators osteoarthritis mmp comp several new genes including suco sorcs medag also identified long noncoding rnas differentially expressed injured joints comparing data gene expression data generated using surgical destabilization medial meniscus dmm ptoa model identified several common genes shared mechanisms study highlights several differences two models suggests model may rapidly progressing model ptoa study provides first account gene expression changes associated ptoa development progression model authors journal orthopaedic research published wiley periodicals inc orthop res
aeolian sand transport results interactions ground surface airflow previous research focused effects sand entrainment mass transport surface features wind velocity influence air density strongly constrains airflow characteristics resulting sand flow widely considered present study entrainment saltation characteristics transport rates examined nine experimental sites ranging elevation sea level aiding lake sea level tanggula mountain pass qinghai tibetan plateau site portable wind tunnel high speed camera system set friction wind velocity threshold friction velocity sand flow structure observed systematically given volumetric airflow lower air density increases wind velocity low air density also creates high threshold friction velocity bagnold wind erosion threshold model remains valid value empirical parameter decreased decreasing air density ranged smallest values reported literature given wind velocity increased altitude reduced total sand transport creeping saltation rate saltation height increased present results provide insights fundamental mechanisms initiation transport sand wind regions extreme temperature altitude example alpine deserts low lying lake basins planets including mars results also provide theoretical support improved sand control engineering measures data empirical equations provided paper improve ability estimate threshold transport conditions wind blown sand
background introduction immunocap isac sige market undertook study evaluate performance multiplex based immunoassay ige measurements allergen components methods study carried european one south african site microarrays different batches eight specific ige sige positive three sige negative serum samples calibration sample sent participating laboratories assays performed according manufacturer instructions results negative positive samples results consistent sites low frequency false positive results similar pattern results samples observed across sites homogeneity analysis measurements sample well clustered indicating good reproducibility unsupervised hierarchical clustering classification via random forests showed clustering identical samples independent assay site analysis raw continuous data confirmed good accuracy across study sites averaged standardized site specific isu values fell close center distribution measurements sites outlier filtering variability across whole study estimated values low moderate high high concentration categories respectively conclusions study shows robust performance immunocap isac immunoassay different sites essentially results obtained irrespective assay site laboratory specific conditions instruments operator use microarrays different batches
cyber physical systems cps used control chemical processes found manufacturing civil infrastructure energy industry transportation many places one common characteristic areas operation critical malfunction potential life threatening past attack cyber part systems lead physical consequences first well known attack cps stuxnet challenging develop countermeasures field without endangering normal operation underlying system research goal detect attacks without interfering cyber physical systems way realized anomaly detection system using passive network monitoring approach based analysing state physical process interpreting communication control system supervisory system state compared model based prediction system serve solid base intrusion detection order realize intrusion detection system testbed built based widely used siemens plcs implementation consists three main parts first task understand network communication order gain information controlled process realized analysing deeply understanding publicly undocumented siemens management protocol resulting protocol parser integrated widely used bro network security monitoring framework gathering information process state prolonged time creates time series time series second step statistical models physical process built predict future states final step new states physical process compared predicted states significant differences considered indicator compromise
aim study investigate effect caffeine symptoms methotrexate mtx intolerance patients follow patients seen period months included work degree mtx intolerance present classified moderate severe intolerance advised caffeine coffee dark chocolate synchronised mtx dose effect assessed good good none among patients seen period mtx intolerance patients degree mtx intolerance total patients minimal intolerance requiring intervention remaining total patients moderate severe mtx intolerance among complete relief symptoms able continue taking advised dose mtx partial improvement continued taking mtx antiemetics minimally better somehow managing complete caffeine failure without relief like caffeine coffee dark chocolate want take caffeine relieved symptoms mtx intolerance partial relief patients significant number patients like take caffeine coffee dark chocolate note northern part india primarily tea drinking population coffee favourite drink
proton exchange membrane pem fuel cells chemically fuelled power supply generally higher energy density lithium polymer battery lipos much lower power density order pem fuel cells increase endurance service battery power supply without decreasing peak power hybridised battery key market overall switch hybrid technology low cost terms size weight money hybrid technology tends generically designed suit power system using regulators ensure voltage matching diodes control direction electrical flow many electric motors controlled speed controllers regulate thrust provided motor accounting fluctuations voltage usually found depleting battery using diode regulator based hybrids electric motor applications therefore inherently inefficient even complicated synchronous converters used due increased cost size weight paper demonstrates ability use ideal diodes control flow electricity hybrid voltage regulation needed motor case furthermore paper explores natural balancing strategy created duty cycling pem fuel cell different points within polarisation curve removing requirement converters match battery voltage changes made improve efficiency hybrid power electronics copyright authors published elsevier ltd behalf hydrogen energy publications llc open access article license http creativecommons org licenses
work proposed introduce signals systems concepts first course analog signal processing integrated laboratory component course structure associated experiments experimental results experiments conducted presented experiments include addition multiplication two signals observing impulse step response lti systems test linearity given system observing two term fourier approximation periodic signals hear see audio signals students taking course asked take multiple choice questionnaire continuous time systems signals systems concepts inventory developed kathleen wage
recent years non invasive techniques evaluation small bowel playing major role management chronic intestinal diseases inflammatory bowel diseases ibd diagnostic performances magnetic resonance imaging computed tomography ultrasound field small bowel disorders assessed established two decades newer sonographic techniques strain elastography shear wave elastography put forward assessment disease activity characterization ibd related damage setting crohn disease gastrointestinal disorders data preliminary research clinical studies shown promising results regards ability elastographic techniques differentiate inflammatory fibrotic tissue distinction ibd activity inflammation ibd related damage fibrosis currently considered crucial assessment management patients moreover elastographic techniques currently considered setting intestinal disorders rectal tumors appendicitis aim paper offer comprehensive narrative review non invasive techniques available assessment small bowel disorders particular emphasis inflammatory bowel diseases summary current evidence use elastographic techniques setting
introduction organizations successfully achieve mission objectives benefit competent effective management since important factor organization survival success aim study determine influential determinants human resources development among health services senior managers commanders method descriptive analytical research undertaken cross sectional study late sample included people among health services managers commanders studied organization data collected questionnaire analyzed using spss software findings results showed influential determinants development senior health service managers commanders consisted ideological innovation behavioral perception skill technical skills human skills decision making skill physical capabilities spiritual ability mental ability motivation attitude team work communication intelligence learning technical knowledge general basic knowledge importance mentioned determinants top management organizations significantly percent conclusion overall based results research important influential determinants lie ideological innovation behavioral areas accordingly recommended important determinants emphasized human resources development managers besides talent seeking activities performed based determinants
monotonic triaxial compression triaxial extension torsional shear tests carried geotextile reinforced sand reinforced clay mainly investigate effects rotation principal stresses mechanical behavior reinforced soil materials tests carried unreinforced reinforced specimens geotextile layers three different confining pressures investigation monotonic behavior reinforced materials different stress paths triaxial compression triaxial extension torsional shear shows direction principal stresses profound effects stress strain curve shear strength slope intercept failure envelope test results reveal geotextiles improve mechanical properties sand clay since strain failure undrained shear strength increase number geotextile layers sand clay addition test results indicate geotextile inclusion enhances mechanical properties geotextile reinforced sand clay however geotextiles seems effective used reinforce sands
examined whether cognitive behavioral therapy cbt would influence relationship two distinct forms emotion regulation cognitive reappraisal expressive suppression satisfaction life patients social anxiety disorder sad compared healthy adults baseline study patients sad reported lesser use cognitive reappraisal greater use expressive suppression lower levels satisfaction life randomized controlled trial cbt versus waitlist control group study resulted indicated cbt group significant group time interactions use cognitive reappraisal satisfaction life use expressive suppression regression analyses study provide insight predictive value expressive suppression emotion regulation post cbt life satisfaction
information granulation powerful tool data analysis processing however much attention devoted application tool data stored relational structure paper extends notion information granules relational case two information systems intended store relational data proposed study also extends granule description language express information granules derived relational data proposed approach enables analyze given problem different levels granularity relational data find application searching patterns data mining
health care organizations must adopt culture safety implement effective fall prevention protocols teach back method useful strategy health providers determine patient understanding information taught maintain safe environment prevent falls purposeful rounding proactive approach ensure patient assessments accurate research supports patients use call light less nurses participate hourly rounding article provides reader evidence based fall prevention interventions tips using teach back method fall prevention tools safely care patients ages
high priority imaging based research identification structural basis confers greater risk spinal disorders new evidence indicates factors related sex influence fetal development axial skeleton girls born smaller vertebral cross sectional area compared boys sexual dimorphism present throughout life independent body size smaller female vertebra associated greater flexibility spine could represent human adaptation fetal load also likely contributes higher prevalence spinal deformities exaggerated lordosis progressive scoliosis adolescent girls compared boys greater susceptibility spinal osteoporosis vertebral fractures elderly women men
filtering characteristics multiple ring resonator mrr filters modeled investigated ring resonators mrr identical perimeters coupling coefficients distribution provide passband characteristics steeper roll flatter top greater stopband rejection single ring resonator theoretical results indicated optical loss micro rings strong influence characteristics mrr filters novel attempt made employ graphical approach analytical derivation optical transfer functions mrr filters represented signal flow graph diagrams elsevier gmbh rights reserved
paper includes country level virtual water data environmental kuznets curve ekc water pollution virtual water accounts total amount water required produce good stages production paper constructs water independence index defined water required domestic production divided amount water required imported goods results suggest increase trade openness importing water intensive goods may lower water pollution levels
paper focuses dynamic modeling simulation control advanced automatic pumping station canal level remote control system using abb plc programmable logical controller based fuzzy logic controller system designed agricultural land water level canals rivers low traditional system irrigation working well system automated two different controllers first controller automate water reservoir gate according upper lower limits reservoir level second controller dealt speed two pumps respect set point water level canal controlling monitoring real time visualization system hmi humane interface machine connected applied control method based fuzzy logic system designed matlab simulink communicate plc opc server using gateway gprs based system communication done plc canal water level meter digital control unit plc eth gets data system take require actions make decision operate pumping station simulation results show system effectively operate automatic well manual conditions depending selection switch
granulite terrains worldwide characterized large mean grain sizes important exception high pressure felsic granulites bohemian massif european variscan belt recrystallization original coarse grained ternary feldspar led formation fine grained similar mixed matrix dominated plagioclase feldspar change occurred temperatures similar degrees probably caused chemically induced decomposition related slight cooling enhanced deformation continental collision resulting microstructure shows indications diffusion creep assisted melt enhanced grain boundary sliding minor coarsening occurred associated deformation dislocation creep aggregation mineral phases using thermodynamics based model grain size evolution show stability fine grained microstructure crucially depends zener pinning two phase mineral matrix pinning efficiently hinders grain growth small grain size resulted ternary feldspar decomposition stable even high temperatures late switch grain size sensitive creep dislocation creep rather difficult explain temperature strain rate stress changes however simple incorporation melt solidification successfully simulate behavior alternatively switch associated grain size growth related mineral phase aggregation lower pressure temperature conditions resulting decrease pinning efficiency study suggests fine grain size bohemian granulites contrast common coarse grained type stems abrupt recrystallization high pressure high temperature conditions pinning fine grained matrix process may cases significantly suddenly reduce strength lower continental crust allow efficient redistribution elsevier rights reserved
improve inversion accuracy time domain airborne electromagnetic data propose parallel inversion algorithm airborne data based direct gauss newton optimization forward modeling performed frequency domain based scattered secondary electrical field inverse fourier transform convolution transmitting waveform used calculate responses sensitivity matrix time domain arbitrary transmitting waves optimize computational time memory requirements use footprint concept reduce model size obtain sparse sensitivity matrix improve inversion use openmp library parallel computing test proposed parallel inversion code using two synthetic datasets field dataset time domain airborne inversion results suggest proposed algorithm effective efficient practical
studies shown deaf hearing impaired students many difficulties learning applied disciplines medicine engineering computer programming study aims investigate readiness deaf students pursue higher education applied sciences specifically computer science involves investigating capabilities computer skills applications computer programming integral component technological field facilitate development scientific advances devising manner teaching deaf hearing impaired population give opportunity contribute technology sector would allow students join scientific world otherwise generally unable participate limitations encounter study showed deaf students jeddah eager continue higher education large percentage students keen studying computer science particularly provided right tools
ant colony based optimization approach based stigmergy behavior natural insects ant colony optimization shows promising behavior dynamic problems like travelling sales person tsp problems tsp like problems paper discusses variants aco algorithms well measures performance using tspantsim simulation tool aybars dogan adv eng tsp hard problem shows fluctuant behavior instances available online library tsplib paper focuses behavior aco algorithm problem instances basic idea behind analytical behavioral study help algorithm design parameter settings well problem instance characteristics paper concludes remarks algorithm design criteria dynamic problem like tsp analytical outcome
evidence human cerebellum involved motor control also cognitive functions several studies shown language related activation lateralized toward right cerebellar hemisphere people accordance leftward cerebral cortical lateralization language general contralaterality cerebral cerebellar activations terms behavior hand use elicits asymmetrical activation cerebellum hand preference weakly associated language lateralization however known whether functional relations reflected anatomy investigated volumetric gray matter asymmetries cerebellar lobules mri data set comprising subjects tested cerebellar asymmetries associations handedness correlations cerebral cortical anatomical asymmetries regions important language hand motor control defined two different automated image analysis methods brain atlases supplemented extensive visual quality control significant associations cerebellar asymmetries handedness found significant associations cerebellar lobular asymmetries cerebral cortical asymmetries found none correlations greater mostly method atlas dependent basis large highly powered study conclude overt structural manifestation cerebellar functional lateralization connectivity respect hand motor control language laterality
novel micro coordinate measurement machine micro cmm introduced viable device used high precision high accuracy measurement part dimensions micron scale design considers eliminating abb error intended achieve submicron accuracy work envelope least study prototype new micro cmm built mathematical measuring model explicitly define coordinate probe directions represented algorithm find workspace implemented error model machine created effect structural errors probe position studied analytically significance geometric parameter studied order minimize measuring error achieve best machine design finally results analytical error model confirmed monte carlo analysis moreover real measurements micro cmm compared error model
replicability findings essential prerequisite research basic clinical research however low replicability findings recently reported replicability may affected research biases sufficiently controlled existing research standards several biases researcher allegiance selective reporting well known affecting results psychotherapy pharmacotherapy research specific additional biases may affect outcome therapist allegiance therapist effects impairments treatment implementation meta analyses specific biases relevant psychotherapy pharmacotherapy research biases yet systematically discussed context replicability using list biases starting point discuss bias impact replicability illustrate bias selective findings recent research showing several biases yet sufficiently controlled presently applied research standards biases pernicious effect replicability findings sake research credibility critical avoid biases future research control biases improve replicability propose systematically implement several measures psychotherapy pharmacotherapy research adversarial collaboration inviting academic rivals collaborate reviewing study design prior knowing results triple blind data analysis including subjects investigators data managers statisticians data analysis research teams crowdsourcing last least updating reporting standards consort template intervention description replication tidier
card based protocols enable easily perform cryptographic tasks secure multiparty computation using deck physical cards since first card based protocol appeared many protocols designed protocol usually described series somewhat intuitive verbal descriptions turn card shuffle two cards apply random cut five cards hand formal computational model card based protocols via abstract machine constructed virtue formalization card based protocols treated rigorously example enables one discuss lower bounds number cards required secure computations paper overview computational model applications designing protocols survey recent progress card based protocols presented
study evaluated association vitamin bone markers development osteoporosis palestinian postmenopausal women even though vitamin deficiency high recruited subjects associated osteoporosis except bones hip age obesity strongest determining factors disease purpose purpose study investigate association bone mineral density bmd serum vitamin levels parathyroid hormone pth calcium obesity bone turnover markers palestinian postmenopausal women methods three hundred eighty two postmenopausal women years recruited various women clinics bmd assessment women osteoporosis normal served controls blood samples obtained serum calcium pth bone formation terminal propeptide pinp bone resorption serum terminal telopeptide type collagen ctx markers results women osteoporosis statistically significant lower mean weight height body mass index bmi serum calcium compared controls significant differences detected mean values bone turnover markers ctx pinp pth two groups women vitamin deficiency severe insufficiency represented study subjects multiple logistic regression showed age bmi significantly affected bmd vitamin significant association bmd lumbar spine bmi positively correlated bmd pth negatively correlated vitamin logistic regression showed odds ratio osteoporosis decreased increasing bmi overweight obese conclusions direct correlation bmd pth bone turnover markers vitamin except lumbar spine negative correlation bmd age positive correlation bmi observed protective effect obesity osteoporosis complicated effect obesity vitamin pth
composite penalties widely used inducing structured properties empirical risk minimization erm framework machine learning composite regularizers despite superior performance grasping structural sparsity properties often nonsmooth even nonconvex makes problem difficult optimize proximal average recently proposed approximation technique targeting regularizers features tractability implementation theoretical analysis however current based methods notwithstanding promising performance handling composite penalties traditional techniques either slow convergence scale well large datasets make ideal technique optimizing erm composite penalties paper proposes new based algorithm called increpa incorporating approximation incremental gradient framework proposed method optimal based method features lower per iteration cost faster convergence rate convex composite penalties guaranteed convergence even nonconvex composite penalties experiments synthetic real datasets demonstrate efficacy proposed method optimizing convex nonconvex erm composite penalties
given potential dangers unethical decisions workplace become increasingly important managers hire promote leadership positions morally inclined behavioral ethics research contributed effort examining array individual difference variables locus control play role morality however past research focused mostly direct causal effects much processes including mediation different factors especially morality based decrease unethical choices purpose current research examine process includes subconscious conscious decision pathways moral attentiveness curbs unethical decision making individual level findings study employing participants cheating task reveal accurate ethical prototypes moral awareness situation decreased unethical decisions moral attentiveness found positively related constructs addition accurate ethical prototypes found partial mediator perceptual moral attentiveness less cheating moral awareness found partial mediator reflective moral attentiveness less cheating theoretical practical implications findings discussed
propose investigate semantics peer data exchange systems different peers related data exchange constraints trust relationships two elements plus data peers sites local integrity constraints made compatible via semantics characterizes sets solution instances peers intended possibly virtual instances peer obtained data repair semantics introduce investigate semantically correct answers peer query called peer consistent answers defined answers invariant different solution instances show solution instances specified models logic programs stable model semantics repair semantics based null values used sql databases also independent interest repairs single databases respect integrity constraints
pcr aid diagnosis invasive fungal disease ifd large number house methodologies drives technological diversity providing robustness make difficult identify optimal strategies limiting standardization widespread acceptance matter efficient pcr utility limited quality extracted nucleic acid chapter highlights benefits limitations affecting nucleic acid extraction process focusing recent recommendations multicenter evaluation provided optimal standardized methodology
among emerging nonvolatile memory nvm technologies resistive memories including phase change memory pcm spin transfer torque magnetic random access memory stt ram metal oxide resistive ram reram considered promising replacements conventional dynamic ram dram build future main memory systems main memory databases benefit nice features low leakage power nonvolatility high density pcm good read performance low read energy consumption stt ram low cost reram crossbar architecture however also disadvantages long write latency high write energy limited lifetime bring challenges database algorithm design nvm based memory systems paper focus design ubiquitous tree aiming make nvm friendly present basic cost model nvm based memory systems distinguishes writes reads propose detailed cpu cost memory access models search insert delete operations tree based proposed models analyze cpu costs memory behaviors existing nvm friendly tree schemes find suffer three issues address issues propose three different schemes experimental results show schemes efficiently improve performance reduce memory energy consumption extend lifetime nvm based memory systems
pancreatic ductal adenocarcinoma devastating disease poor prognosis regardless stage date mainstay therapy advanced disease chemotherapy little incremental improvements outcome despite extensive research investigating new treatment options current practices continue utilise fluorouracil gemcitabine containing combinations need novel therapeutic approaches mandated ongoing poor survival rates associated disease one approach may include manipulation ribosome biogenesis nucleolar stress response recently applied haematological malignancies lymphoma prostate cancer promising results review focus current therapeutic options pancreatic ductal adenocarcinoma complexities associated developing novel treatments particular emphasis role nucleolus treatment strategy
decades engineers scientists studied phenomenon production speech eye creating effective efficient systems human computer interaction paper presents large number experiments made create automatic speech recognition system asr spoken romanian connected digits state art hidden markov acoustic models hmms finite state grammar language model used order build optimize fully functional digit recognizer system romanian language applications speech recognition daily life multiple truly limits use cases technology niche applications like medical interfaces industrial command control systems consumer applications modern phone operating systems offer speech interfaces interact system rich mathematical framework hmms makes statistical approaches feasible task one goals paper confirm validity reproducibility method another objective integration components toolkits necessary build recognition system briefly describe processes involved speech representation mathematics behind analysis improving optimizing primary evaluation metrics results show advantage training larger speaker database order obtain independent speech recognizer wer improvements compared dependent model speaker database used evaluation implementation system experiments along evaluation results decoding optimization provided
aimed evaluating ratio frequency stealth weapon system paper briefly introduces ratio frequency stealth technology development history radar system points radar system realize ratio frequency stealth ability gives index evaluating ratio frequency stealth capability radar system finally introduces limitation existing evaluation index
background number studies association clock genes polymorphisms cancer susceptibility increased last years results often conflicting comprehensive overview quantitative summary evidence field available results literature search identified eligible studies comprising subjects cases investigating polymorphisms involving clock genes overall primary subgroup meta analyses gene variants performed study distribution tumor follows breast cancer prostate cancer pancreatic cancer non hodgkin lymphoma glioma chronic lymphocytic leukemia colorectal cancer non small cell lung cancer ovarian cancer identified single nucleotide polymorphisms snps significantly associated cancer risk npas mixed breast cancer shiftworkers mixed breast breast clock breast breast rora breast breast cancer postmenopausal breast rorb breast cancer postmenopausal per breast cancer subgroups assessed level quality evidence intermediate also identified polymorphisms lower quality statistically significant associations conclusions work supports hypothesis genetic variation clock genes might affect cancer risk findings also highlight need efforts research field order fully establish contribution clock gene variants risk developing cancer methods conducted systematic review meta analysis evidence association clock genes germline variants risk developing cancer assess result credibility summary evidence graded according venice criteria false positive report probability fprp calculated validate result noteworthiness subgroup meta analysis also performed based participant features tumor type breast cancer subgroup stratified work conditions estrogen receptor progesterone receptor status menopausal status conditions associated risk breast cancer different studies
erythema marginatum characteristic skin rash seen patients hereditary angioedema hae however confused urticaria leading delay correct diagnosis aim study clarify often erythema marginatum misinterpreted urticaria potentially leading physicians refrain testing hae studies published urticaria prodromal symptoms hae thus incidence parameters also investigated total patients affiliated national hae centre included retrospective prospective data skin eruptions prodromal symptoms collected fifty six percent patients positive history erythema marginatum half patients experienced erythema marginatum misinterpreted urticaria prevalent prodromal symptoms skin symptoms malaise psychological changes fatigue gastrointestinal symptoms hae patients erythema marginatum longer diagnostic delay presumably caused misinterpretation rash urticaria
various industries automotive leisure show great interest foaming thermoplastic polyurethane tpu physical blowing agents hence study aims investigate effects absorption carbon dioxide nitrogen melt tpu solubility interfacial tension using pressure volume temperature apparatus high pressure temperature combined magnetic suspension balance solubility carbon dioxide nitrogen thermoplastic polyurethane melt measured temperatures degrees degrees pressures mpa solubility super critical fluids scf tpu melt compared semiempirical data theoretical values calculated sanchez lacombe equations state eos surface tension tpu scf interface measured using axisymmetric drop shape analysis profile observed dependency interfacial tension temperature high pressures decreases reduction scf solubility high temperatures relationship interfacial tension density difference polymer supercritical fluid also examined using generalized macleod equation elsevier rights reserved
new single stage converter designed grid connected wind energy conversion system changes variable frequency output electrical generator constant frequency supply fed electrical grid single stage converter eliminates multistage operation link filter elements thus resolves size weight reliability issues complete system simulated using matlab sps different wind conditions results demonstrated generator current regulated follow optimized reference current corresponding variation wind speed order reduce losses increase power capability system
obtain analytical expressions torques angular speed induction motor simple geometry resembling geometry first induction motor investigated arago rotor conducting disc rotating magnetic poles two axis solenoids displaced space degrees apply results discuss theory ubiquitous electromechanical watt hour meter comparison theoretical result angular speed measurements propose simple experiment induction motor aluminum disc rotor constructed
longitudinal studies investigated use coping strategies among police recruits study investigated perceived life work stressors appraisal coping seven month police recruit academy training program participants police recruits completed ways coping questionnaire three time points approximately three months apart average age recruits years range separate repeated measures analyses variance conducted examine coping scores statistically significant decreases although small observed reported emotion focused problem focused seeking social support coping strategies results suggested police recruits undergo academy training rely fewer coping strategies deal life work stress longitudinal studies needed assess methods police recruits utilize manage stress academy training results inform stress management interventions
paper describes construction testing six high model embankments constructed three different gravimetric water content gwc values study performance validate set moisture reduction factors mrfs introduced authors recent studies earlier mrf values obtained series pullout interface shear tests soil reinforcement materials mrf study defined ratio soil reinforcement interface shear strength increased gwc value optimum moisture content omc shear strength omc representing construction conditions therefore mrf values used account anticipated reduction shear strength soil geotextile reinforcement interface caused wetting stability analysis design reinforced soil structures constructed marginal soils embankment models built using lean clay gwc values ranging omc omc included single reinforcement layer near top embankment provided horizontal soil reinforcement interface subjected shear sliding overriding block soil caused surcharge loading embankment two different woven polypropylene geotextile products used build six model embankments model instrumented total sensors measure soil gwc matric suction excess pore pressure reinforcement strains earth pressure deformations embankment model test box test results embankment tests study indicate change matric suction gwc could significant influence soil geotextile reinforcement interface strength wetting soil soil geotextile interface construction service life reinforced soil slopes could considerably reduce shear strength resulting lower factors safety stability results study showed within range gwc values examined omc embankment model constructed omc yielded greatest shear strength stability subjected strip footing load mrf values model embankments constructed omc found low models reinforced different woven geotextiles comparable apparent opening size aos different ultimate strength values mrf results presented study although obtained soils different compacted gwc values indicate loss soil reinforcement interface shear capacity result wetting reinforced soil structures involving marginal fills could significant deserve proper attention design systems american society civil engineers
south american atlantic rainforest one kind ecosystem considered biodiversity hotspot however last decades intensively reduced original surface water resources water quality one main goods services system provides people monitoring management recommendations present study focused determining nutrient content nitrate nitrite ammonium phosphate physiochemical parameters temperature electrical conductivity turbidity dissolved oxygen total dissolved solids surface water rainforest mountain rivers argentina analyzing human health risk assessing environmental distribution determined pollutants analyzing water quality indices wqi obj wqi min addition total coliform bacteria dataset used literature turbidity total dissolved solids nitrite exceeded guideline value recommended national international guidelines several sampling stations spatial distribution pattern analyzed principal component analysis factor analysis pca showing well defined groups rivers wqi showed good adjustment rated water quality good excellent sampling sites wqi therefore study suggests use wqi min monitoring water quality region also water treatment coliform total dissolved solids turbidity
reduction crown rot disease observed uvc irradiated banana fruit berangan associated activation defense response mechanisms increased peroxidase polyphenol oxidase activities well accumulation lignin phenolic compounds crown tissue phenylalanine ammonia lyase activity transmission electron microscope micrographs revealed uvc retarded losses cell compartments disintegrations fibril fraction cell wall structure crown tissue uvc treatment fungal inoculation induced accumulation phenol storing cells could create antimicrobial environment host tissue combating fungal colonization moreover formation cell wall lignification heterogenous matrix cell wall appositions site fungal penetration clearly observed uvc irradiated crown tissue otherwise absent control crowns structures might important physical barriers induced irradiation prevent diffusions toxin enzyme crown rot infecting fungi elsevier rights reserved
objective assess impact non radiographic axial spondyloarthritis axspa patients society based real world evidence adelphi axspa disease specific programme cross sectional survey rheumatologists patients germany france spain italy methods physicians completed patient record forms next two patients consulting axspa diagnosis physician judgement patients invited complete patient self completion form outcomes assessed responders non responders treated without biological agents results total patients included fulfilment classification criteria varied across countries assessment spondyloarthritis international society classification criteria commonly met criteria including amor european spondyloarthropathy study group criteria applied less frequently german patients condition classified without formal criteria despite diagnosed axspa patients met criteria ankylosing spondylitis euroqol dimensions utility scores lower patients axspa versus general population matched controls non responders treatment impaired activity measured work productivity activity impairment questionnaire versus responders clinical outcomes consistently better biological treated versus naive patients average pretreatment pain levels respectively reduced respectively time survey conclusion axspa associated significant qol societal burden study german french spanish italian patients treatment biological agents associated improved qol considerable variability patients clinical characteristics observed across countries studied education aimed improving awareness condition may needed
previously found oxytocin receptor otr binding density medial amygdala mea correlated positively social interest motivation investigate conspecific male rats otr binding density central amygdala cea correlated negatively social interest female rats determined causal involvement otr mea cea sex specific regulation social interest adult rats injecting otr antagonist side side social interest test min sex juvenile exposure otr blockade cea decreased social interest males females treatments behavioral effect explore sex specific involvement system cea social interest used vivo microdialysis determine possible sex differences endogenous release cea social interest interestingly males females showed similar levels extracellular release baseline social interest suggesting factors local release mediate sex specific role cea otr social interest moreover found positive correlation cea release social investigation time females reflected reduced cea release social interest females expressed low compared high social interest discuss possibility reduction release may consequence rather cause exposure social stimulus overall findings show first time extracellular release cea similar males females otr cea plays causal role regulation social interest toward juvenile conspecifics males ibro published elsevier ltd rights reserved
aim present article derive exact integral equation green function hubbard model equation motion procedure like original hubbard papers though exact integral equation allow solve hubbard model represents strong constraint approximate solutions analogous sum rule already obtained literature use spectral moment technique think however equation motion procedure easily related historical procedure original hubbard papers also discuss examples possible applications sum rule propose analyse solution fulfilling used pedagogical introduction mott hubbard metal insulator transition
although mitochondrial dysfunction consistent feature alzheimer disease brain blood molecular mechanisms behind phenomena unknown replicated previous findings demonstrating reduced expression nuclear encoded oxidative phosphorylation oxphos subunits subunits required translation mitochondrial encoded oxphos genes blood people alzheimer disease mild cognitive impairment interestingly accompanied increased expression mitochondrial encoded oxphos genes namely residing closest transcription start site polycistronic heavy chain mitochondrial transcript atp transcribed light chain show mitochondrial dna copy number unchanged suggesting change steadystate numbers mitochondria suggest imbalance nuclear mitochondrial genomeencoded oxphos transcripts may drive negative feedback loop reducing mitochondrial translation compromising oxphos efficiency likely generate damaging reactive oxygen species author published elsevier inc open access article license
changes human pigmentary system lead imbalances distribution melanin skin resulting artefacts known pigmented lesions work takes departing point biological data regarding human skin pigmentary system melanocytes life cycle presents reaction diffusion model simulation shape features human pigmented lesions simulation disorders many applications dermatology instance assist dermatologists diagnosis training related pigmentation disorders study focuses however applications related computer graphics thus also present method seamless blend results simulation model images healthy human skin context model contributes generation realistic skin textures therefore realistic human models order assess quality results measured compared characteristics shape real synthesized pigmented lesions show synthesized real lesions statistically significant differences shape features visually results also compare favourably images real lesions virtually indistinguishable real images
purpose study investigated overactive bladder oab functions male patients used antidepressant drugs ads previously examined female patients based conflicting data literature regarding effects oab differences male female urinary system physiologies anatomical hormonal methods study included male patients control group healthy subjects experimental group patients taking ads different disorders patients completed overactive bladder validated oab questionnaire international consultation incontinence questionnaire short form iciq beck depression inventory bds results oab iciq bds scores antidepressant users significantly higher control group highest prevalence oab symptoms observed patients taking venlafaxine lowest prevalence patients taking sertraline moreover frequency oab antidepressant groups statistically significant univariate logistic regression analyses showed significant relationship presence oab antidepressant usage bds score age patient multivariate logistic regression analyses association presence oab antidepressant usage statistically significant conclusions present study showed incidence oab severity oab symptoms increased males using antidepressants various disorders may due unique pharmacological effects molecular individual level serotonin norepinephrine reuptake inhibitors
article addresses tension subsidies sustainability rural water supply systems based research carried minas gerais brazil brazilian rainwater harvesting programme one million rural cisterns pmc fieldwork included survey beneficiary households depth interviews well workshop pmc managers concluded heavy government subsidies construction cisterns resulted alienation users highlighted cases studied strong government participation critical expanding access water
aims patients often experience adverse events aes intravesical onabotulinumtoxina bont treatment overactive bladder refractory antimuscarinic agents investigated prevalence predictive factors aes patients methods total patients underwent intravesical bont suburothelial injection age gender overactive bladder subtypes medical morbidities neurological diseases patients recorded maximum flow rate max voided volume post void residual pvr volume voiding efficiency baseline analyzed identify adverse events within months treatment results acute urinary retention aur developed patients urinary tract infection uti occurred within months treatment large pvr volume occurred patients months treatment respectively aur developed significantly often men patients years old baseline max greater incidence uti age years low max low voiding efficiency large pvr baseline also risk factors adverse events conclusion aur uti large pvr volume common aes bont treatment patients overactive bladders risk developing aes bont injection informed possible aes wiley periodicals inc
background children low middle income countries lmics risk problems cognitive social behavioural development factors lack cognitive stimulation harsh parenting practices severe persistent aggression early childhood central genesis problems interventions target intersection early childhood development parenting early violence prevention required order meaningfully address problems methods conducting randomised controlled trial evaluate parenting intervention caregivers children aged months designed promote child cognitive socioemotional development khayelitsha low income peri urban township south africa families randomly allocated book sharing intervention group wait list control group intervention train caregivers supportive book sharing young children training carried small groups period weeks data collected baseline post intervention months post intervention addition targeting child cognitive development intervention aims improve child socioemotional functioning discussion benefits early book sharing bebs trial aims evaluate impact early parenting intervention several key risk factors development violence including aspects parenting child cognition prosocial behaviour aggression socioemotional functioning study carried lmic violence constitutes major social health burden since intervention brief modest levels training readily deliverable lmic contexts demonstration benefit child cognitive socioemotional development would significance
background collaborative care evidence based approach management depression within primary care services recommended within nice guidance however uptake within limited review aims investigate barriers facilitators implementing collaborative care methods systematic review literature undertaken uncover barriers facilitators reported previous research collaborative care depression primary care results review identified barriers facilitators successful implementation collaborative care depression studies across range settings framework analysis applied using collaborative care definition commonly reported barriers related multi professional approach staff organisational attitudes integration poor inter professional communication facilitators successful implementation particularly focussed improving inter professional communication standardised care pathways case managers clear role boundaries key underpinning personal qualities limitations papers independent title abstract screened multiple reviewers thus limiting reliability selected studies many different frameworks assessing quality qualitative research little consensus appropriate circumstances use quality threshold led exclusion six papers could included information barriers facilitators conclusions although evidence base collaborative care strong population within primary care depression large preferred way implement approach identified
idiopathic pulmonary fibrosis ipf chronic progressive debilitating disease unknown etiology leads death nearly half patients within years past years scientific community made tremendous progress towards standardized diagnostic prognostic algorithms led generation ats ers jrs alat guidelines latest guidelines provided fundamental diagnostic algorithms set diagnosis majority cases however leave significant minority patients without diagnostic importantly therapeutic umbrella end current guidelines revisited light research advances including tools fibromics time provide practical guidance real world ipf order address patients needs scope review article summarize challenges everyday ipf clinical practice make effort provide realistic answers patients questions elsevier ltd rights reserved
multiple sclerosis immune mediated demyelinating disease central nervous system pathogenesis remains largely unclear much attention paid role micrornas mirs regulation autoimmune disease found first time mir expression significantly increased periphery blood mononuclear cells pbmc cerebrospinal fluid csf patients expression positively correlated disease severity demonstrated cells especially lineage major source mir expression using gain loss function approaches verified mir could enhance differentiation characterized regulated expression levels ror gamma interleukin beta potent driver pathogenic cells able strongly induce mir expression cells activating kappa pathway additionally identified mir directly targeted protein tyrosine phosphatase non receptor type ptpn known anti inflammatory player capacity suppress differentiation also observed markedly decreased expression ptpn pbmc csf patients results suggest mir might promote differentiation thus aggravate disease inhibiting ptpn elsevier inc rights reserved
symbolic computation satisfiability checking two research areas individual scientific focus sharing also common interests development implementation application decision procedures arithmetic theories despite commonalities two communities rather weakly connected aim newly accepted project fetopen csa strengthen connection communities creating common platforms initiating interaction exchange identifying common challenges developing common roadmap theory along way tools industrial applications paper report aims first activities project formalise relevant challenges unified community
purpose adults presenting borderline personality disorder bpd score poorly measures health related quality life hrqol little known hrqol adolescents bpd type presentations treatment impacts quality life primary aim use routinely collected quality life outcome measures pre post treatment dialectical behaviour therapy dbt adolescents address gap secondary aims benchmark data euroqol dimensions outcomes clients treated clinical trials assess potential benchmarking tool method four adolescent dbt teams routinely collecting outcome data using pseudonymised secure web based system supplied data consecutive discharges results young people dbt programmes severely impaired hrqol scores lower programme admission reported published studies using adults bpd diagnosis one study adolescents treated depression adolescents treated achieved reliable clinical change hrqol improved admission discharge large effect size results statistically significant clustering programme outcomes accounted conclusion young people treated nhs dbt programmes bpd type presentations poorer hrqol adults bpd diagnosis adolescents depression treated published clinical trials detected reliable change group adolescents programme outcome clustering suggests measure web based monitoring system provide mechanism benchmarking clinical programmes
changes understanding regarding relationship androgens prostate cancer led changes use testosterone therapy evidence supports finite ability androgens stimulate prostate cancer growth maximum achieved low testosterone concentrations called saturation model saturation point corresponds maximal androgenic stimulation evidence reviewed herein regarding relationship testosterone prostate cancer relatively new practice offering testosterone therapy men history prostate cancer although prospective controlled trials performed results reassuring
present research investigated whether enhanced perceptions moral purity drive effects intergroup cross group friendships intentions interact homosexuals high school students reported direct extended cross group friendships homosexuals well beliefs regarding moral character sexual minority participants reported desire interact homosexuals future results showed face face encounters extended contact homosexuals increased perceived moral purity turn fostered positive behavioral intentions results revealed specific role moral purity sense differential perceptions along moral domains autonomy community mediation effects behavioral tendencies toward homosexuals importance findings improving intergroup relations discussed together importance integrating research intergroup contact morality
moving beyond distinction biological social facts proved challenging due several basic methodological ontological differences among scientific disciplines aim paper show attention schema theory hereafter ast developed michael graziano provides useful addition existing integrative approaches used overcome impediments interdisciplinary crossfertilization influence range interconnected institutional situational biographical psychological neural genetic variables considered simultaneously parsimonious way paper provides overview three basic methodological ontological differences dividing scientists researching human nature society draws ast selection existing approaches interdisciplinary vein demonstrate move beyond reductionist tendencies discipline view ast intrinsic brain processes social situational aspects intricately intertwined continuously influence shaping specific attentional focuses social identities biographical experiences symbols roles subject positions contribute directing attention certain kinds stimuli details information time intrinsic predispositions make individuals inclined attend different types information accounting brain basis awareness subjective experience ast used clarify social identities influence attention thus linkages individual cognition wider institutional structures finally paper considers relationships cognitive institutional levels analysis highlights importance latter distinct level analysis way paper charts multidirectional interactive causal relationship intrinsic brain processes attention conscious awareness relate wider institutional structures joint attentional interactions higher levels aggregation
background international classification diseases icd grouping allergic hypersensitivity disorders involving respiratory tract topographic distribution regardless underlying mechanisms triggers concepts currently use allergic hypersensitivity conditions order strengthen awareness deliberate creation new allergic hypersensitivity disorders involving respiratory tract section icd propose make building process public methods new frame constructed cover gaps previously identified based consensus academic reports icd principles constant bilateral discussion kept relevant groups representing specialties resulted proposals submission icd online platform results allergic hypersensitivity disorders involving respiratory tract section covers entities distributed across five main categories proposals submitted resulted intensive collaboration allergy working group relevant expert working groups icd governance conclusion establishment icd allergic hypersensitivity disorders involving respiratory tract section allow dissemination updated concepts used clinical practice many different specialties health professionals
background hunger associated food insecurity household level considered global public health problem long term adverse consequences children health study aims determine factors associated child hunger nationally representative sample bangladesh among food insecure households methods data derived food security nutritional surveillance project children aged months belonging food insecure households contributed analysis information food security household level collected days preceding survey descriptive statistics served illustrate variables studied multiple logistic regression analysis conducted identify significant risk factors child hunger results overall children found hungry adjusting seasonality residence type education level household head variables female headed households severely food insecure households households women education poorest asset quintile amount rice consumed per household per week found significantly independently associated child hunger conclusions potential risk factors examined study found significant independent association five variables child hunger sex household head household food insecurity status educational status household women asset index despite sampled household food insecure degree household food insecurity status appeared strongest predictor child hunger
paper discusses positivity preserving using rational cubic ball interpolant form cubic quadratic two parameters sufficient condition positivity derived one parameter meanwhile one free parameter control final shape interpolating curves degree smoothness achieved numerical results rational cubic ball spline two parameters gives smooth interpolating positive curves well visually pleasing computer graphics visualization furthermore scheme better existing schemes easiness use less computation numerical results produced using mathematica
objectiveswe aimed examine treatment patterns patient reported outcomes pros benign prostatic hyperplasia bph patients overactive bladder oab symptoms methodsseven hundred forty seven patients included prospective observational study primary endpoint describe medical treatment patterns bph patients oab symptoms secondary endpoint determine pros patients clinical outcome assessed using international prostate symptom score ipss pros measured using bph related qol questionnaire korea bph qol euroqol dimension resultswhen starting study patients received blocker monotherapy whereas received combination therapy anticholinergics patients completed month treatment patients still received blocker monotherapy still received combination therapy anticholinergics received subsequent anticholinergics addition blocker patients stratified storage subscore higher voiding subscore lower patients anticholinergics without although treatment groups reported significant improvement baseline significant group differences changes ipss bph qol found conclusionsabout one third patients received blocker monotherapy one third received combination therapy anticholinergics another one third received subsequent anticholinergics addition blocker storage subscore higher patients anticholinergics without vice versa voiding subscore similar improvement clinical outcomes pros observed treatment groups
contemporary discourse changing modes production autonomist marxist theorists paolo virno franco berardi antonio negri michael hardt maurizio lazzarato provides insights ongoing shift economy based material labour producing physical goods one served increasingly immaterial labour light texts paper revisits point origin autonomist political thought olivetti factory italy problems programmed cybernetic human machine assembly line first observed endeavours examine objects created result immaterial labour practices well machines may actually played key role forming contemporary modes immaterial labour accomplished examining case studies demonstrate various iterations idea essential concept immaterial labour practice programming featuring unique constellation olivetti products purpose text add historical relevance theoretical rigour seemingly disparate series objects present potential genealogy immaterial labour brought design making olivetti machines
purpose construction projects complex projects taking place dynamic environments necessitates accounting different uncertainties planning stage significant lack management tools repetitive projects accounting uncertainties construction environment purpose paper present algorithm optimized scheduling repetitive construction projects uncertainty design methodology approach fuzzy set theory utilized model uncertainties associated various input parameters developed algorithm two main components optimization component buffering component optimization component presents dynamic programming approach processes fuzzy numbers buffering component converts optimized fuzzy schedule deterministic schedule inserts time buffers protect schedule anticipated delays agreement index used capture user desired level confidence produced schedule sizing buffers algorithm capable optimizing cost time objectives example project drawn literature analysed demonstrate capabilities developed algorithm allow comparison results previously generated findings testing algorithm revealed several findings fuzzy numbers utilized capture uncertainty various inputs without need historical data modified algorithm capable optimizing schedules different objectives uncertainty finally used capture users desired confidence final schedule originality value project planners utilize algorithm optimize repetitive projects schedules modelling uncertainty different input parameters without need relevant historical data
legendre sequence possesses several desirable features pseudorandomness view different applications high linear complexity profile cryptography small aperiodic autocorrelation radar gps sonar prove first nontrivial bound arithmetic autocorrelation another figure merit introduced mandelbaum error correcting codes
paper first describes development nonpararnetric identification method linear parameter varying lpv state space models applies nonlinear process system proposed method uses kernel based least squares support vector machines svm parametric identification methods require proper selection basis functions order avoid parametrization structural bias problem variance bias tradeoff avoided estimating functional dependencies state space representation lpv scheduling variables using measured input output data svm framework proposed formulation allows svm reconstruct uncover static well dynamic dependencies scheduling variables multi input multi output mimo lpv models achieved assuming states measurable common scenario online control many chemical processes described lumped parameter models proposed method require explicit declaration feature maps nonlinearitics assumed model structure instead requires selection nonlinear kernel function tuning parameters developed identification method applied continuous stirred tank reactor cstr model realistic noise conditions another numerical example along cstr system illustrates performance proposed algorithm static dynamic dependence scheduling variables ifac international federation automatic control hosting elsevier rights reserved
distributed generation technology spreading rapidly owing advantages clean environment loss reduction voltage improvement utilities pakistan welcoming generations increase supply capacity industries installing dgs meet load requirements order reduce energy bills dgs used supply spare power back utility even peak durations interconnection changes electrical network characteristics existing utility network protection problems may occur form relay settings islanding increased short circuit currents paper investigates effects interconnection short circuit currents feeder site industrial area karachi modeled simulated short circuit analysis analysis shows interconnection radial feeder increases short circuit level nodes feeder
background smoking cessation following hospitalization acute coronary syndrome acs significantly reduces subsequent mortality depressed mood major barrier cessation post acs although existing counseling treatments address smoking depression independently acs patients integrated treatment addresses developed integrated treatment combining gold standard cessation counseling behavioral activation based mood management behavioral activation treatment cardiac smokers bat purpose pilot randomized controlled trial test feasibility acceptability preliminary efficacy bat standard care methods participants recruited hospitalization acs randomly assigned bat nicotine patch offered conditions smoking mood stress outcomes collected end treatment week follow results fifty nine participants bat recruited weeks assessment completion conditions treatment acceptability fidelity high week follow adjusted odds ratios favoring bat day point prevalence abstinence continuous abstinence time first smoking lapse significantly longer bat days weeks effect sizes mood stress outcomes ranged eta partial significant treatment effects positive affect negative affect stress conclusions design study proved feasible acceptable results provide preliminary evidence combining behavioral activation standard smoking cessation counseling could efficacious high risk population larger trial longer follow warranted
paper presents combined daylight airflow network building energy simulation public rental housing prh development hong kong fulfil requirement local green building guidance numerical modelling results partly validated site measurements period highest monthly average outdoor temperature different ventilation control strategies simulated optimize natural ventilation performance simulation results show full day ventilation strategy contributes lower average peak indoor temperatures compared non ventilation night ventilation scenarios indoor operative temperature worst case vacant flat lies upper acceptability limits ashrae modelled period july side least habitable area case buildings predicted experience higher average daylight factor compared local green building guidance furthermore energy saving potential combined natural ventilation daylight strategies anticipated air conditioning lighting compared baseline building respectively elsevier rights reserved
basal forebrain important regulator hippocampal cortical activity alzheimer disease significant loss dysfunction cholinergic neurons within also hypertrophy fibers containing neuropeptide galanin understanding galanin interacts circuitry critical determining role galanin overexpression plays progression examined location function galanin medial septum diagonal band dbb region show galanin fibers located throughout dbb intermingled cholinergic gabaergic neurons whole cell patch clamp recordings dbb neurons acute slices reveal galanin decreases tetrodotoxin sensitive spontaneous gaba release dampens muscarinic receptor mediated increases gaba release dbb effects blocked pre exposure beta amyloid peptide beta optogenetic activation cholinergic neurons dbb increases gaba release back onto cholinergic neurons forming functional circuit within dbb galanin disrupts cholinergic gabaergic circuit blocking cholinergic induced increase gaba release data suggest galanin works reduce inhibitory input onto cholinergic neurons prevent cholinergic induced increase inhibitory tone disinhibition cholinergic neurons could serve compensatory mechanism counteract loss cholinergic signaling occurs progression
paper presents development preliminary evaluation integrated group cognitive behavioral treatment cbt comorbid mood anxiety substance use disorders session manualized treatment developed collaboratively mental health program teaching hospital community based addictions service administered settings results uncontrolled effectiveness trial treatment completers suggest integrated group cbt may reduce stress alcohol use symptoms improve substance refusal self efficacy changes symptoms anxiety depression drug use significant although effect size anxiety reduction medium range nonetheless clinical significance treatment effects mood anxiety substance use symptoms modest changes coping skills quality life significant although medium large effects observed changes several coping skills participants reported highly satisfied treatment found treatment strategies useful noted improvement functioning particularly socially methodological sample size limitations warrant rigorous follow investigations treatment results considered context current literature integrated psychological treatments common comorbidities elsevier ltd rights reserved
objective accurate laboratory results important disease detection classification treatment follow study aimed evaluate records within year samples rejected biochemistry laboratory methods data rejected samples ankara children health diseases hematology oncology training research hospital biochemistry laboratory january december retrospectively screened laboratory information system errors evaluated according type working groups results total samples sent biochemistry laboratory one year total samples sent central laboratory sent emergency laboratory samples sent central laboratory rejected detection preanalytical errors samples sent emergency laboratory rejected common sources error clotted samples inappropriate sample volumes besides common errors observed hemogram blood gas study groups conclusion extremely important keep error prone preanalytical phase affects quality results laboratory control obtain accurate qualified results error proofing planned taking account characteristics samples sent laboratory
present thorough characterization fragmentations observed threshold collision induced dissociation tcid experiments protonated triglycine ggg using guided ion beam tandem mass spectrometer gibms kinetic energy dependent cross sections ionic products observed analyzed provide barriers six primary products loss three secondary products two tertiary products high energy accounting multiple ion molecule collisions internal energy reactant ions unimolecular decay rates competition channels sequential dissociations relaxed potential energy surface scans performed blyp level theory used identify transition states tss intermediates six primary one secondary products geometry optimizations single point energy calculations performed several levels theory theoretical energies compared experimental energies found give reasonably good agreement particular level theory good agreement experiment theory validates reaction mechanisms explored computationally elsewhere allows identification product structures formed threshold energies present work presents first measurement absolute experimental threshold energies important sequence ions non sequence ions loss refines previously measured
based matching theory antecedence partnership formation buyer supplier manufacturing engineering explored results show strategic level matching operational level matching positively associated partnership formation cultural level matching moderates effects strategic level matching operational level matching partnership formation
early diagnostics preclinical stage alzheimer disease utmost importance drug development clinical trials prognostic guidance since soluble beta oligomers considered play crucial role disease pathogenesis several methods aim quantify beta oligomers body fluids cerebrospinal fluid csf blood plasma highly specific sensitive method surface based fluorescence intensity distribution analysis sfida successfully established oligomer quantitation csf samples study explored sfida method quantitative measurements synthetic particles blood plasma purpose edta citrate heparin treated blood plasma samples five individual donors spiked coated silica nanoparticles beta sinaps applied sfida assay based assay parameters linearity coefficient variation limit detection found edta plasma yields suitable parameter values quantitation oligomers sfida assay limit detection
article highlights long term serial follow adolescents osteoid osteoma considered even complete excision nidus owing possibility delayed onset progression femur head neck deformities osteoarthritis important recognize sequelae osteoid osteomas bone edema new bone formation alter normal anatomy proximal femur report two cases osteoid osteoma proximal femur showed progressive hypertrophy femoral neck excision nidus subsequent cam type femoroacetabular impingement fai requiring additional osteochondroplasty procedures even though hip pain relieved immediately excision nidus cases cam type fai developed postoperative follow months case years case hip pain subsided within month osteochondroplasty full range motion hip joint achieved maintained postoperative follow year case months case
study aimed investigate effects typhoons dust storms harvested rainwater quality rainwater samples collected rainwater harvesting systems northern taiwan september april five typhoons one dust storm hit taiwan period harvested rainwater analyzed including electrical conductivity turbidity alkalinity total organic carbon toc acute biotoxicity test concentration metals three anions results harvested rainwater dust storm showed higher turbidity toc normal rainwater conversely due strong winds dilution effect ion concentrations harvested rainwater typhoons lower normal rainwater addition biotoxicity harvested rainwater dust storm typhoons significantly different normal rainwater
success efforts green building depends largely integrating approaches building design education however existing studies green building focused technical issues sociocultural educational aspects less examined order alleviate problem paper presents international workshop explores green building design taught global teamwork project using green building assessment system leadership energy environmental design leed checklist framework examples vernacular architecture precedents results empirical survey reveals gap students general learning green building developing developed country suggests collaborative project experience may facilitate bridging gap exchanging technical cultural information related sustainability
ankylosing spondylitis chronic inflammatory disease characterized pathological osteogenesis inflammation however pathogenesis pathological relationship osteogenesis inflammation disease remain largely unknown mesenchymal stem cells mscs multipotent progenitor cells capable osteogenic differentiation immunoregulation recently demonstrated mscs patients asmscs greater potential osteogenic differentiation mscs healthy donors hdmscs therefore seems component pathological osteogenesis previous studies indicated immunoregulatory abilities mscs change following differentiation however subsequent effects asmscs abnormal osteogenic differentiation unclear demonstrated asmscs secreted monocyte chemoattractant protein mcp hdmscs osteogenic differentiation enhanced mcp secretion augmented monocyte migration increased classical macrophage polarization enhanced tnf alpha secretion inhibiting mcp secretion osteogenic differentiated asmscs using lentiviruses encoding short hairpin rnas ameliorated dysfunctions blocking erk pathway asmscs corrected abnormal osteogenic differentiation inhibited mcp overexpression prevented subsequent monocyte dysfunction finally mcp expression regulated osteogenic differentiation asmscs vivo locally augmented osteoblasts ossification sites patients summary study determined mcp overexpression abnormal osteogenic differentiation asmscs triggers monocyte dysfunctions propose novel hypothesis pathological osteogenesis lead inflammation hypothesis may contribute reveal precise pathological relationship osteogenesis inflammation field osteoimmunology asmscs secreted mcp abnormal osteogenic differentiation mcp overexpression leads monocyte dysfunctions pathological osteogenesis lead inflammation
report fabricating method ion conducting carbon electrodes top industrially produced pvdf membrane spin coating spin coating desirable due potential application large scale actuator manufacturing possibility produce thin electrodes industrial grade membrane chosen order investigate accurately results spin coating without considering deviations present hand made membrane spin coating surface resistivity measurements via four point probe described detail production process electrode suspension suspension dispensing developed fine tuned spin coater programmed obtain electrodes uniform electrical properties arrangement spin coater slightly altered remove swelling bubble formation effects concurrent usage porous membrane electrodes produced developed method measured analyzed thickness film measured micrometer screw gauge four point probe used measure sheet resistivity addition film studied scanning electron microscope best cases coefficient variation sheet conductivity electrode sheet conductivities median coefficient variation thickness electrodes varied proof concept developed method working actuator spin coated electrodes produced
work present analyze three approaches adaptive control operating point cascade erbium doped fiber amplifiers edfas aimed optical networks performance enhancement first approach called annealing search heuristic backpropagation flexible output ashb flex uses machine learning concepts update amplifier gains iterative process second one exhaustive method uses exhaustive search evaluate possible solutions problem obtain optimum solution last one maxgain heuristic method uses previous knowledge problem obtain solutions amplifier characteristics specifications obtained experimentally measurements gain noise figure gain ripple power consumption commercially available edfas performed comparisons among approaches others found literature results show three proposals outperformed previous ones terms noise figure gain ripple ber example link four amplifiers exhaustive method achieved reduction cascade noise figure reduction gain ripple reduction ber almost two orders magnitude compared traditional approach defines gain compensate loss previous link however computation time exhaustive method becomes prohibitive number amplifiers link increases maxgain ashbflex obtained similar solutions close optimum operation point reasonable time
one adverse effects shrinking transistor sizes processors become increasingly prone hardware faults time number cores per die rises consequently core failures longer ruled future operating systems many core machines incorporate fault tolerance mechanisms present csr strategy recovery unexpected permanent processor faults commodity operating systems approach overcomes surprise removal faulty cores also tolerates cascading core failures core fails user mode csr terminates process executing core migrates remaining processes run queue cores show hardware transactional memory may used overcome failures critical kernel code solution scalable incurs low overhead designed integrate modern operating systems implemented linux kernel using haswell transactional synchronization extension tested real system
accurate definitions phenomena essential scientific enterprise definition violence fully capable accounting exclusion behaviors accidents self defense inclusion behaviors child abuse sexual offenses manslaughter violence research produced numerous sometimes conflicting definitions violence organized general camps exemplars approach social psychology approach public health approach animal research approach approach strengths limitations fully distinguish violence behaviors requires incorporating elements comprehensive definition violence includes essential elements behavior intentional unwanted nonessential harmful sophisticated recognition elements needed example shortened telomeres known consequence child abuse far serious harm scratch bruise fully heal days many problems field due least part insufficient attention definitions minimization sexual violence bullying behaviors map onto prototypical exemplars precise definitions violence improve surveillance promote accurate identification causes consequences enhance evaluation treatment outcomes guide development prevention programs among benefits
power load forecasting important part power grid scheduling operation maintenance also basis economic operation security electric power system important significance stability development electric power system paper introduces theory wavelet analysis combined neural network form wavelet neural network forecasting model analysis characteristics wavelet neural network wavelet neural network algorithm design comparison results wavelet neural network neural network proved wavelet neural network model characteristics high prediction accuracy fast convergence speed better prediction effect
article focuses cultural meaning art mediated intra interpersonal touch space amits phenomena amongst group korean female graduate students workshop student created shared personalized attachment based cloth album sharing albums participants cultural based amits behaviors included frequent reaching touching manipulating partner album analyses survey suggested amits themes respect care support degree mediated familiarity engaging amits also facilitated expression autobiographical memories interpersonal relationships communication respect could replace functions physical touch elsevier ltd rights reserved
present study deals development finite element based solution methodology investigate active control dynamic response delaminated composite shells piezoelectric sensors actuators formulation based first order shear deformation theory eight noded isoparametric element used coupled piezoelectric mechanical formulation used development constitutive equations modeling delamination multipoint constraint algorithm incorporated finite element code simple negative feedback control algorithm coupling direct converse piezoelectric effects used actively control dynamic response delaminated composite shells closed loop employing newmark time integration scheme validity numerical model demonstrated comparing present results available literature number parametric studies locations sensor actuator patches delamination size location radius curvature width ratio shell types loading conditions carried understand effect transient response piezoceramic delaminated composite shells
objective bipolar disorder associated cognitive deficits yet little known associations cognition vascular risk age population study investigated whether patients demonstrate stronger apparent agerelated decline inhibitory performance processing speed methods full medical history obtained euthymic healthy comparison individuals delis kaplan executive functions color word interference subtests administered participants assess inhibitory performance condition conditions positive vrpos andvr negative vrneg groups created based presence one morevr factors results vrpos participants demonstrated significantly worse inhibitory performance older age whereas age inhibition significantly related vrpos group vrneg true conclusion patients may also risk greater decline inhibitory performance age longitudinal studies needed investigate contributions ofvr cognitive decline among older patients
rationale rates adolescent electronic cigarette use increasing little study chronic effects use components cigarette aerosol known pulmonary toxicity objectives investigate associations cigarette use chronic bronchitis symptoms wheeze adolescent population methods associations self reported use cigarettes chronic bronchitic symptoms chronic cough phlegm bronchitis wheeze previous months examined southern california children health study participants completing questionnaires grade measurements main results ever cigarette use reported used cigarettes last days current users risk bronchitic symptoms increased almost twofold among past users odds ratio confidence interval compared never users fold among current users risk increased frequency current use days days past days compared never users associations attenuated adjustment lifetime number cigarettes smoked secondhand smoke exposure however risk bronchitic symptoms among past cigarette users remained elevated adjustment relevant potential confounders also observed among never cigarette users statistically significant associations cigarette use wheeze adjustment cigarette use conclusions adolescent cigarette users increased rates chronic bronchitic symptoms investigation needed determine long term effects cigarettes respiratory health
background development mandible closely related meckel cartilage mandibular division trigeminal nerve muscles mastication objectives aim study investigate muscular attachments developing mandible prenatal life material methods observations carried serial sections stained according various histological methods results stage rod shaped meckel cartilage followed general curvature mandibular process otic capsule future symphysis menti stylohyoid styloglossus muscles visible close relation ventral end meckel cartilage medial surface cartilage mylohyoid muscle well genioglossus geniohyoid muscles visible stage muscles established temporary attachments meckel cartilage time near posterior end meckel cartilage primordia articular disc pterygoid muscle developed primordium masseter muscle observed close relation angular portion meckel cartilage stages observations developing coronoid process showed attachment lateral pterygoid muscle meckel cartilage stage conclusions muscles connected meckel cartilage end week development moved onto developing mandible observations appear confirm hypothesis stating muscles attached meckel cartilage indeed influence mandibular movements resulting premature dislocation mandible adv clin exp med
paper reports high resolution measurements velocity field within front free surface viscoplastic surges inclined channel free surface shape position unyielded plug layer inside surges also monitored experimental results compared predictions thinlayer model based lubrication approximation despite simplicity model appears provide accurate description flow surge predicted layer flow structure clearly observed upper plug layer progressively thinning towards front tip flow close contact line discrepancies model observed plug layer completely disappears velocity profiles become sheared across whole flow depth experimental free surface shape also deviates theoretical counterpart distance contact line lubrication model fails quantified experiment varies times maximum height flow future experimental dataset shall provide unique benchmark assess predictive capabilities sophisticated flow models elsevier rights reserved
objective purpose study characterize sacroiliac joints sijs findings patients diffuse idiopathic skeletal hyperostosis dish condition characterized using resnick classification criteria ossification least four contiguous vertebrae thoracic spine preserved disk space without radiographic evidence intraarticular sij abnormalities materials methods pelvic examinations patients dish fulfilling resnick criteria spinal age sex matched control subjects whose entire spine lacked evidence dish total men women mean age years retrospectively evaluated presence intra extraarticular bridging osteophytes spurs subchondral cystlike changes erosions sclerosis sijs excluded patients known ankylosing spondylitis inflammatory related diseases data analyzed using multivariate anova examine degree difference patients dish control subjects logistic regression analysis used generate odds ratios examine discriminatory ability roc analysis applied examine sensitivity specificity results results frequency anterior bridging posterior bridging entheseal bridging joint ankylosis significantly higher among patients dish compared control subjects respectively comparisons conclusion intraarticular ankylosis seen entity included resnick classification criteria common among patients dish implies radiologic classification criteria dish need revised
flow induced vibrations fivs cylinder commonly occur cylindrical body exposed flow however appearance behavior widely diverging depending flow condition characteristics cylinder supporting structure making prediction quite difficult hence many serious accidents caused far structures machines typical well known fivs category karman vortex induced vibration kviv galloping torsional flutter work simple convenient apparatus designed made reproduce three vibrations apparatus effective classroom lecture fluid mechanics demonstrating easily fivs induced simple apparatus even though prediction remains important difficult problems solved practical engineering
many osteoporosis related vertebral fractures unappreciated detection important presence increases future fracture risk found height loss useful tool detecting patients vertebral fractures low bone mineral density vitamin deficiency may lead improvements patient care study aimed determine height loss used identify patients vertebral fractures low bone mineral density vitamin deficiency hospital database search four patient groups including diagnosis osteoporosis related vertebral fracture osteoporosis osteopenia vitamin deficiency control group evaluated chart documented height loss average year time period data retrieved patients men women height loss sensitivity detecting vertebral fractures respectively positive likelihood ratios detecting vertebral fractures height loss respectively height loss lower sensitivities positive likelihood ratios detecting low bone mineral density vitamin deficiency compared vertebral fractures specificity height loss respectively odds ratios patient loses height one four diagnostic groups compared patient loses height higher younger male patients study demonstrated prospective height loss effective tool identify patients vertebral fractures low bone mineral density vitamin deficiency although lack height loss rule diagnoses significant height loss present high positive likelihood ratios support workup
paper presents novel model fitting spatial straight line based chebyshev norm problem firstly formulated minimax problem reformulated semidefinite programming sdp problem could solved many interior point algorithms application proposed approach two problems arising manufacturing engineering planning initial location cylindrical cutter flank milling evaluation spatial straightness error discussed examples numerical simulations illustrate efficiency novel model elsevier inc rights reserved
introduction new physiopathological concepts regarding idiopathic intracranial hypertension iih recommend endovascular treatment refractory patients transverse sinus stenosis objectives assess role transverse sinus stenting treatment symptomatology patients iih method clinically refractory patients impaired venous drainage transverse sinus submitted cerebral angiographies patients pre poststenotic pressure gradients mmhg submitted endovascular treatment results seven patients underwent cerebral angiography manometry stenting performed six cases pressure gradient assessment cases showed improvements headache resolution papilledema discussion conclusion although role endovascular therapy studied data suggest may improve clinical symptoms signs iih selected patients
paper provides systematic study location choice new polluting firms driven five year plan water pollution reduction mandates china explore unique dataset environmental statistics contains polluting manufacturing firms newly established period conditional logit model provides strong evidence changes new polluting firms location choice coastal provinces strict environmental mandates western provinces lax environmental mandates demonstrates distinct location patterns heterogeneous polluting firms foreign polluting firms generally driven mandates domestic polluting firms resistant driven western provinces result potential pollution transfer would threaten fragile water environments public health western provinces thus posit perverse incentive current environmental policy recommend integrated water management well close coordination local governments improve efficacy environmental regulation china journal comparative economics state key laboratory pollution control resource reuse school environment nanjing university nanjing china school government nanjing university nanjing china school business nanjing university nanjing china hopkins nanjing center nanjing china association comparative economic studies published elsevier inc rights reserved
high standard newborn care especially primary level needed address neonatal mortality rate south africa current approach continuing training health care workers uses traditional methods centralised teaching formal tutors away place work longer affordable achievable desirable particularly rural areas innovative system self directed learning groups nurses caring mothers newborn infants uses specially prepared course books without need trainers using self study supported peer discussion groups nurses take responsibility professional growth builds competence confidence sense pride since perinatal education programme provided continuing learning opportunities thousands nurses southern africa number prospective trials demonstrated study groups significantly improve knowledge understanding attitudes clinical skills quality care provided mothers infants recent review successful participants across wide range provinces ages home languages documented success project using question answer format promote problem solving case studies simple skills workshops multiple choice tests module addresses common conditions appropriate care practices thorough drying birth delayed cord clamping skin skin care breast feeding basic resuscitation correct use oxygen therapy hand washing blood glucose monitoring promotion parental bonding training material also available free charge line website well presented books downloaded onto personal computers tablet readers smart phones supplemented regular sms text messages providing nurses relevant knowledge bites nurses caring newborn infants easy affordable access continuing education promises nationwide improvements newborn care
role secularization european fertility decline interest demographers often explore relationship macro level identifying religious affiliation proxy however relationship thoroughly studied individual level utilizing indicators personal religious conviction affiliation aim present article examine reproductive practices religious affiliation order understand impact secularization fertility decline accomplished using event history analysis longitudinal parish register data sundsvall religious affiliation identified family level reproductive practices analysed using cohort tfr descriptive statistics cox proportional hazard regressions free church affiliates overall higher probability another child affiliates state church however differences decreased time fertility dropped throughout society free church affiliates showed strongest significant reduction probability another birth indicates time within free churches ideas respectability restraint came mean birth control form abstinence within marriage became important practice formation gendered religious identities leading relatively early decrease fertility
explore favorable structural system cable stayed bridges ultra kilometer main span based fully self anchored cable stayed bridge main span partially earth anchored cable stayed bridge scheme main span designed numerical investigation dynamic characteristics aerostatic aerodynamic stability two bridge schemes conducted results compared suspension bridge similar main span considering aspect wind stability feasibility using partially earth anchored cable stayed bridge super long span bridges ultra kilometer main span discussed results show compared fully self anchored cable stayed bridge suspension bridge similar main span partially earth anchored cable stayed bridge greater structural stiffness better aerostatic aerodynamic stability consequently becomes favorable structural system super long span bridges ultra kilometer main span
purpose study determine anxiety prospective music teachers piano exams examine effects peer self assessments anxiety exam achievement individuals high performance test anxiety female students anxious compared males students fourth class anxious students graduated fine arts high schools lower anxiety levels positive significant relation test anxiety music performance anxiety significant relation determined piano course achievement scores test performance anxiety despite awareness coping recommendations students high levels anxiety experienced anxiety could influence performance exams
paper analyses food represented cinema using main examples spanish films current day focus food eating become semiotic objects semiotic objects used cinematographic tool undertake analysis important differentiate three food related aspects act eating places eating food methodological approach paper based study functions distinct food related aspects movies indicators national identity functions span large range narrative aesthetic ideological metaphorical symbolic structural referential dimensions contribute development characters well framing stories critical representations also criticize habits social groups ideologies gender roles etc
every evolution fluid uniquely described energy tensor converse true energy tensor may describe evolution different fluids problem determining called inverse problem problem may admit unphysical non deterministic solutions paper devoted solve inverse problem perfect energy tensors class perfect fluids evolving local thermal equilibrium starting point previous result coll ferrando math phys showing thermodynamic fluids evolving admit purely hydrodynamic characterization characterization allows solving inverse problem compact form paradigmatic case perfect energy tensors representing evolution ideal gases studied detail applications examples outlined
analytical model study free vibration suppression laminated curved beam embedded actuating layers presented study magnetostrictive layers used control enhance vibration suppression governing differential equations model derived using hamilton principle analytical solution equations governing laminated curved beam embedded magnetostrictive layers obtained simply supported boundary conditions velocity feedback constant gain distributed controller using terfenol smart material chosen achieve vibration suppression effects material properties radius curvature lamination scheme placement magnetostrictive layers respect laminate midplane vibration suppression studied details
purpose purpose article analyze strengths limitations research designs studies implementing coping based training interventions adolescents methods quantitative mixed methods studies selected reviewed critical analysis strengths limitations validity concerns results methodological strengths weaknesses assessed major limitation studies reviewed selection bias quasi experimental studies randomized controlled trials practice implications improved coping strategies skills found participants coping skill training intervention programs decreased depressive symptoms less impact individual disease burden found treatment intervention groups
article using literature data method questionnaire survey method interview method mathematical statistics logical analysis wuhan institute physical education volleyball specially selected students research object volleyball sports wuhan institute specially selected students sports injury status investigated volleyball elective class students sports injury awareness sports injury incidence sports injury pathological conditions sports injury type sports injury parts movement injury reason analyzed detail basis puts forward prevention strategy sports injury great significance improving level volleyball training improving college volleyball training effect
research conducted within framework national science foundation sponsored summer research experience undergraduate reu students research considers small scale mathematical models simple one story structures subjected free base motion excitations installed without passive damping devices gain understanding dynamic behavior reviewing active semi active damping means applied researched today using computer programming numerical methods goal understand counteract catastrophic disasters structures caused earthquakes research broken number matlab simulations experiments order understand basic dynamic control features required design earthquake resilient buildings experiments include free vibration experiments test stiffness columns different heights test natural frequency damping ratio one story structure different mass loads active control applied experimental system experiencing accelerations attributed northridge kobe centro mendocino earthquakes robustness comparisons made control control control earthquake inputs shaker fuzzy logic controller developed effectively control transient vibrations uniqueness control concept fuzzy control continuously varies damping characteristics semi active tuned mass damper tmd concluded fuzzy logic based tmd effective regular passive tmd providing half settling times wiley periodicals inc comput appl eng educ
presented first direct observation electric field induced rotation epoxy based polymer rotors polymer disks gears prepared micrometer dimensions rotors electrorotation sub millimeter sized tools studied uniform electric field rotational speed micron sized polymer rotors conveniently tuned wide range rpm electric field intensity opening new perspectives use micro electric motor applications
present study investigated needs adult education staff pertaining adult students mental health issues within local school board study utilized mixed methods design divided progression three separate studies initial focus group conducted identify participants concerns provide direction needs assessment survey administered entire population adult education teachers board two workshops designed members staff based needs identified surveys evaluation workshops indicated workshops valuable training desired educating teachers students learning context mental health challenges able provide necessary tools jobs successfully comfortably
cross sectional study conducted group pharmacy students assess relation nutritional knowledge awareness university students nutrition habits health related performance indicators students subjected questionnaire designed approach four health related topics including nutrition literacy health awareness nutritional habits health related performance answers topic collected statistical analysis performed using graphpad prism software including measure gender differences correlative studies significant difference genders overall responses discrepancies certain questions observed female students showed higher awareness nutrition concepts practices poor implementation side observed study revealed positive significant correlation existed health related performance nutrition literacy healthier eating habits lifestyle associated nutrition conscious students knowledgeable students concluded knowledge alone enough stimulate individuals practice healthy habits implementations required raise awareness issues hand
euler number binary image important topological feature many image processing image analysis pattern recognition computer vision applications paper proposes new run based euler number computation algorithm conventional run based algorithm processes rows given image one one top bottom single phase row finds runs row records start end locations run compute neighbor runs contrast algorithm calculates euler number image two phases first phase process odd rows alternately find runs record end location second phase process remaining even rows find runs calculate neighboring runs current row rows immediately using recorded run data using method number accesses required compute euler number decreases almost cases analysis time complexity experimental results demonstrate algorithm outperforms conventional euler number computation algorithms
purpose little published data exist impact urethral stricture surgery urinary urgency evaluated urinary urgency urge incontinence anterior urethroplasty materials methods male patients underwent stage anterior urethroplasty retrospectively identified centers patients preoperative month greater postoperative subjective urinary urgency assessments included study patients received anticholinergic medications preoperatively excluded univariate multivariate analysis done analyze association patient characteristics preoperative postoperative symptoms well improvement worsening symptoms surgery results symptom followup data urgency urge incontinence available patients respectively preoperatively men reported urgency reported urge incontinence postoperatively decreased men urgency forurge incontinence men reported improvement urgency experienced improvement urge incontinence without preoperative symptoms showed worse symptoms including urgency urge incontinence new urgency likely develop men higher body mass index men stricture recurrence less likely show improvement urgency older men likely new urge incontinence less likely notice improvement urge symptoms conclusions prevalence urgency urge incontinence male patients anterior urethral stricture high majority men experience symptom stability improvement urinary urge symptoms following anterior urethroplasty
introduction large area provinces naples caserta campania region southern italy characterized environmental problems caused illegal dumping industrial domestic waste fields roadsides cases wastes burned thereby spreading persistent contaminants material sometimes burnt area dubbed terra dei fuochi land fires objectives search trace elements fruits vegetables grown area design setting monitoring plan detect level presence inorganic bio essential metals vegetables fruits growth considered area content trace elements determined inductively coupled plasma mass spectrometry icp microwave assisted digestion procedure results monitoring activity vegetable samples fruit samples collected municipalities included area called terra dei fuochi resulted average content toxic metals cadmium lead fruits vegetables lower minimum level established european legislation values contents significantly lower contents detected areas high environmental impact caused presence industrial plants conclusions presence toxic potentially toxic elements fruits vegetables grown terra dei fuochi area attributable variety environmental factors geological characteristics soil air irrigation water pollution illicit practices industrial waste disposal health risk consumers products seem exist therefore alert presence pollutants environment need monitoring activities still remain
backgroundpost stroke cognitive impairment psci occurs commonly linked development dementia investigated relationship demographic clinical stroke symptoms stroke onset presence psci years stroke methodswe accessed anonymized data virtual international stroke trial archive vista including demographic clinical variables post stroke cognitive impairment defined mini mental state examination mmse score assessed univariate relationships baseline stroke symptoms psci years following stroke retaining significant relevant clinical factors covariates final adjusted logistic regression model resultswe analysed data patients recent median days stroke transient ischaemic attack tia mean age years patients male follow data available patients years respectively year patients mmse years mmse adjusting age stroke severity hypertension diabetes type qualifying event initial stroke impairment leg paralysis associated increased rate psci year years associations consistent subgroup analysis restricted ischaemic stroke transient ischaemic attack conclusionsbesides well known determinants psci age stroke severity presence vascular risk factors also leg paralysis associated subsequent psci years stroke
acute stress impairs hippocampusdependent spatial memory retrieval synaptic mechanisms associated hippocampal long term depression ltd enhancement adult rats endogenous hydrogen sulfide recognized novel gasotransmitter neural protective roles however little attention paid understanding effects spatial memory retrieval impairment observed protective effects nahs donor spatial memory retrieval impairment caused acute stress synaptic mechanisms results showed nahs abolished spatial memory retrieval impairment hippocampal ltd enhancement caused acute stress glutamate transporter inhibitor trans pyrrolidine dicarboxylic tpdc indicating activation glutamate transporters necessary exogenous exert roles moreover nahs restored decreased glutamate uptake hippocampal synaptosomal fraction caused acute stress dithiothreitol dtt disulfide reducing agent abolished decrease glutamate uptake caused acute stress nahs eradicated decreased glutamate uptake caused dithio bis nitrobenzoic acid dtnb thiol oxidizing agent collectively revealing exogenous increases glutamate uptake reducing disulfide bonds glutamate transporters additionally nahs inhibited increased expression level phosphorylated jun terminal kinase jnk hippocampal region caused acute stress jnk inhibitor eliminated spatial memory retrieval impairment hippocampal ltd enhancement decreased glutamate uptake caused acute stress indicating exogenous exerts roles inhibiting activation jnk signaling pathway ibro published elsevier ltd rights reserved
fuzzy algorithm takagi sugeno model implemented develop fuzzy inference system predicting holding capacity suction caisson foundations offshore platforms premise parameters fuzzy model optimized using subtractive clustering algorithm consequent parameters optimally determined via weighted least square estimation input variables used training fuzzy model include aspect ratio caisson undrained shear strength clay angle chain force forms horizontal output proposed fuzzy model capacity suction caisson anchor demonstrate effectiveness fuzzy modeling framework results extensive finite element analyses investigated comparisons trained fuzzy model data demonstrate proposed modeling framework effective method estimate holding capacity offshore suction caisson systems moreover performance fuzzy model robust higher levels input data uncertainties copyright john wiley sons ltd
proteoglycans pgs impact many aspects kidney health disease models permit genetic dissection core protein glycosaminoglycan gag function instrumental understanding roles kidney matrix associated pgs serve critical structural roles organ contribute significantly glomerular barrier normal conditions abnormal expression influences fibrosis inflammation progression kidney disease core proteins arc dispensable nephrogenesis glypican exception maintenance function adult life loss alters susceptibility experimental kidney injury contrast kidney development exquisitely sensitive gag expression fine structure evidenced severe phenotypes mutants genes involved gag biosynthesis article reviews expression normal kidney abnormalities caused disruption mice man
background although age related change junctional zone uterus known previous systematic study age related changes uterine peristalsis observed wave conduction thickest darkest area within purpose examine age related changes uterine peristalsis pre postmenopausal women using cine magnetic resonance imaging mri determine correlation peristalsis weighted imaging material methods cine mri analysis performed premenopausal volunteers postmenopausal women peristaltic frequency detectability thickness evaluated compared two groups premenopausal group correlations age item examined postmenopausal group number years menopause used instead age correlation peristaltic frequency detectability thickness also analyzed results peristaltic frequency detectability significantly differed two groups thickness peristaltic frequency vary significantly age menopause peristalsis observed menopause detectability change significantly age number years menopause thickness significantly increased age menopause vary menopause significant moderate correlation observed detectability peristaltic frequency thickness peristaltic frequency conclusion uterine peristalsis frequency change significantly according age observed peristalsis mri significantly decreased menopause
introduction hypogonadism common endocrine disorder affects men age groups recent shifts public awareness increased screening recognition symptoms updated diagnostic criteria led increase men diagnosed hypogonadal including middle aged older men previously would considered eugonadal increase testosterone replacement therapy trt paralleled increase advancements treatment options although current therapies highly efficacious many men remains need newer therapies cost effective preserve ease use administration mitigate undesirable effects closely mimic physiological levels testosterone areas covered review authors discuss current trts therapies development treatment hypogonadism focus therapies phase investigation recently completed phase study expert opinion several new therapies development authors expect advancements achieving treatment benchmarks meet needs individual symptomatic hypogonadal male increased public awareness hypogonadism trt led welcomed expansion choice trt options include new delivery systems formulations routes administration non testosterone modalities
high velocity chute flows free surface aeration often observed phenomenon called self aeration white waters turbulent shear stresses next free surface large enough air bubbles entrained throughout entire airwater column rapidly varied flow region observed immediately downstream inception point free surface aeration analytical solution air diffusion equation proposed results compare well new experimental data experiments theory indicate flow bulking spans approximately step cavities downstream inception point free surface aeration stepped chute downstream void fraction distributions follow closely earlier solutions air diffusion equation application diffusion equation solution prototype laboratory data shows air bubble diffusivities typically larger momentum transfer coefficient result highlights however marked decrease ratio air bubble diffusivity eddy viscosity increasing reynolds number finding might indicate limitation laboratory investigations air bubble diffusion process self aerated flows extrapolation full scale prototype applications
main aim study examine potential moderator role social context children exposed media alone peers parents relationship frequency media use frequency committed peer aggression study included elementary school students completed following self assessment measures peer violence among school children questionnaire velki kuterovac jagodic vrdoljak exposure media scale velki kuterovac jagodic moderation effect parental peer social context found social context positive effect decreasing correlation watching electronic peer aggression peers social context playing computer games associated decrease physical peer aggression browsing internet parents peers also decreased physical electronic peer aggression importance social context protective factor highlighted discussion
objective aim study determine influence left ventricular dysfunction type pattern neuropsychological dysfunctions among heart failure subjects method sub analysis data subjects recruited cross sectional survey cognitive dysfunction among nigerians performed cognitive performance community screening interview dementia csi word list learning delayed recall wlldr boston naming test bnt modified token test mtt compared heart failure reduced ejection fraction hfref heart failure preserved ejection fraction hfpef clinical echocardiographic correlation analysis cognitive performance performed results subjects hfpef impaired wlldr group hfpef scored lower language domain definition subscale csi wlldr performance mtt bnt comparable two groups inverse relationship found pulse pressure delay recall among cohort hfpef whereas body mass index bmi tricuspid valve ratio tvea showed inverse relationship total csi score cohort hfref conclusions cognitive dysfunction largely similar two groups delay recall however poorer among subjects hfpef regular cognitive screening advocated among subjects prevent non adherence therapeutic options
next generation high speed wireless technologies wirelesshd bring concept several gigabits per second data communication however forward error correction takes place receiver side become real computational challenge far hardware solutions offered high speed convolutional decoding could achieved software solutions paper aims fill gap proposes software level solution offering multi gbps convolutional decoding intend use massively parallel computing power nvidia gpgpus cuda programming environment implement solution decoding method fano algorithm selected relatively low memory requirements computational complexity look ahead mechanism compact history form circular queue presented support high throughput conducted tests showed gpu based algorithm decode gbps elsevier ltd rights reserved
background despite relationship idiopathic pulmonary fibrosis ipf advancing age little known epidemiology interstitial lung disease ild elderly describe diagnoses clinical characteristics outcomes patients elderly time ild diagnosis methods among subjects prospective cohort study ild elderly defined age years diagnoses derived multidisciplinary review differences elderly nonelderly groups determined using chi test analysis variance results subjects enrolled elderly majority elderly subjects white men common diagnoses unclassifiable ild ipf connective tissue disease ctd ild hypersensitivity pneumonitis elderly subjects unclassifiable ild imaging pattern inconsistent usual interstitial pneumonia uip significant differences pulmonary function year mortality nonelderly elderly subjects combined subgroup analysis ipf conclusions although ipf single common diagnosis majority elderly subjects non ipf ild findings highlight need every patient new onset ild regardless age surveyed exposures findings ctd unclassifiable ild common among elderly radiographic pattern inconsistent uip although effect ild may pronounced elderly due reduced global functionality ild severe aggressive group
paper describes creation modelling simulative tool petri nets means possible simulate processes enables vast tool support fields model check graphically oriented simulation software verification advantage process modelling petri nets formal description refills graphical display numbers editors tools petri nets modelling simulation market use created simulation tool petri nets possible model simulate consequently form processes running systems important aims designed tool create model visualize processes operating systems create appropriate models optimize progress educational processes implement rules modellig processes first part concerned definition basic terminology fields modelling principles modelling simulation basic features petri nets implementation forming petri nets tools given strong tool model real processes means created tool possible model simulate processes operating systems educational processes lms possible model rules fuzzy petri nets
saliency detection widely used fields computer graphics multimedia processing many computer graphics tasks image segmentation image labeling tracking rely accurate generation saliency maps however current methods lack ability generate fine boundary foreground background also providing high recall rate saliency detection algorithm proposed paper based rectangular wave spectrum analysis method divide given image several regions convoluted using pre set rectangular wave template determine final saliency value calculating difference region adjacent regions uniqueness compared entire image repeated tests using different data sets produced high accuracy recall rate moreover boundary saliency map clear fine
three experiments examined memory undermining effects daydreaming related stimuli experiments tested whether daydreaming fosters forgetting semantically interrelated material hence catalyzes false memory production experiment examined memory effects different daydreaming instructions experiment daydreaming undermine correct recall semantically interrelated words affect false memories experiment failed find daydreaming exerted memory undermining effects experiment memory effects obtained using different daydreaming instructions together studies fail show appreciable memory undermining effects daydreaming elsevier inc rights reserved
one one strategy among used techniques deal multi class problems machine learning way binary classifier used address original problem since one classifier learned possible pair classes every ensemble method classifier combination becomes vital step classification process even though many combination models developed literature none dealt possibility reducing number generated classifiers training phase ensemble pruning since every classifier supposed necessary account objective paper two fold propose transformation aggregation step lead new combination strategy instances classified basis similarities among score matrices fact allows introduce possibility reducing number binary classifiers without affecting final accuracy show around classifiers removed depending base learner specific problem confidence degrees obtained base classifiers strong influence improvement final accuracy thorough experimental study carried order show behavior proposed approach comparison state art combination models one one strategy different classifiers various machine learning paradigms considered base classifiers results obtained contrasted proper statistical analysis elsevier rights reserved
paper presents structure functionality application improved remote laboratory engineering students hosted ghent university remote laboratory consists two setups ball plate system quadruple water tank system setups introduce basic control aspects pid control design non minimum phase systems also challenging aspects multiple input multiple output control decoupled decentralized systems advanced control strategies internal model control model predictive control investigated setups based feedback study dial targeted bachelor degree students level effectiveness concept shown also possible functional enhancements applied systems pointed feedback survey data concluded remote laboratory attracted attention students positive impact training ifac international federation automatic control hosting elsevier ltd rights reserved
indoor scene classification usually approached computer vision perspective however fields like robotics additional constraints must taken account specifically systems low resources state art techniques cnns successfully deployed paper try close gap theoretical approaches real world solutions performing depth study factors influence classifiers performance size descriptor quality end perform thorough evaluation visual depth data obtained rgb sensor propose techniques build robust descriptors enable real time indoor scene classification descriptors obtained properly selecting combining visual depth information sources elsevier ltd rights reserved
successful quality software projects need able rely sufficient level security order manage technical legal business risks arise distributed development definition sufficient level security however typically captured implicit requirements rarely gathered methodological way unstructured approach makes work quality managers incredibly difficult often forces developers unwillingly operate unclear undefined security state throughout project ideally security requirements elicited methodological manner enabling structured storage retrieval checking requirements paper report experiences applying structured requirements elicitation method list set gathered reference security requirements reported experiences gathered industrial setting using open source platform opencit cooperation industry partners output work enables security quality conscious stakeholders software project draw experiences evaluate reference base line
large combustion plant directive lcpd major largely unstudied environmental regulation large combustion plants analysis electricity supply plants combined heat power plants find controlling country characteristics plant size plants electricity supply combined heat power district heating paper industries higher probability opted emission limit values elvs necessitates eventual plant closure controlling plant size industry increasing amount solid fuel natural gas utilized plant associated decreased likelihood opted elvs elsevier ltd rights reserved
therapeutic value physical exercise bright light therapy dawn simulation several pharmacologic treatments including hypericum john wort adenosylmethionine hydroxytryptophan reviewed focus use treating major depressive disorder children adolescents also alleviating depressed mood general nonclinical population youth treatment discussed published randomized double blind placebo controlled trials summarized along additional selected studies nutritional psychopharmacology several approaches treating depression presented upcoming volume child adolescent psychiatric clinics north america
character animation based motion capture provides intrinsically plausible results lacks flexibility procedural methods motion editing methods partially address limitation adapting animation small deformations environment extend one method called relationship descriptors tackle issue motion editing large environment deformations large deformations often result joint limits violation loss balance collisions method handles situations automatically detecting positioning invalidated contacts new contact configurations chosen preserve mechanical properties original contacts order provide plausible support phases possible find equivalent contact procedural animation generated blended original motion thanks optimization scheme resulting motions continuous preserve style reference motions method fully interactive enables motion adapted line even case large changes environment demonstrate method several challenging scenarios proving immediate application animation softwares video games
recent upsurge investment photovoltaic industry china made outstanding contributions adjustment energy structure order promote investment construction projects state published many fiscal subsidy policies addition unified national subsidy standard local standards developed according local fiscal revenue either greatly improved return investment roi significant effect result many impact factors paper utilizes multi dimensional big dates distributed projects obtain weight factors influencing roi calculation equation roi fitted innovative big data mining method lssvm pso results show construction cost sunshine duration retail electricity tariff subsidy greatest impacts study provides decision makers quantitative basis comprehensive understanding economic aspect distributed projects elsevier ltd rights reserved
work correlation composition heavy distillation cuts corrosion process analyzed according results electrospray ionization fourier transform ion cyclotron resonance mass spectrometry esi icr naphthenic acid species detected seven cuts studied dbe values ranging respectively relative abundance heavy naphthenic acids increase distillation cut temperature degrees residue naphthenic acids class carbazoles class detected polar species corrosion mechanism aisi steel heavy oil distillation cuts determined electrochemical impedance spectroscopy scanning electron microscopy equivalent electrical circuits proposed dehydrated oil distillation cuts residue based observations obtained nyquist bode diagrams resistance values decrease oil cuts function increasing distillation temperature metal film resistance values increase distillation cut temperature compatible formation passive films according microphotographs localized corrosion characterized alveolar cuts pitting cuts elsevier ltd rights reserved
nickel essential metal organisms also common toxic pollutant released water toxicity completely established cyanobacteria reason evaluated effect sub inhibitory concentrations toxigenic strain microcystis aeruginosa microcystins production population growth photosynthetic pigments concentration biomarkers including antioxidant enzymes catalase cat glutathione peroxidase gpx superoxide dismutase sod well macromolecules proteins carbohydrates lipids quantified sem tem observations also performed population growth affected starting growth completely inhibited exposure increased pigments concentration augmented macromolecules increased activities cat gpx alterations internal cell structure also observed integrated biomarker response revealed augmented antioxidant response macromolecules content stress also increased microcystins production aeruginosa affected low concentrations even lower established safe limit protect aquatic biota aside toxic effects produced cyanobacterium stimulation produce toxins could potentiate environmental risks associated water pollution eutrophication elsevier inc rights reserved
public construction one fundamental pillars spanish construction sector current economic depression reduction public investment new infrastructure led decrease activity return higher activity rates achieved economic recovery country would necessary make improvements bidding process order achieve greater functionality flexibility public procurement works
wiener processes received considerable attention degradation modeling last two decades paper propose generalized wiener process degradation model takes unit unit variation time correlated structure measurement error considerations simultaneously constructed methodology subsumes series models studied literature limiting cases simple method given determine transformed time scale forms wiener process degradation model model parameters estimated based maximum likelihood estimation mle method cumulative distribution function cdf probability distribution function pdf wiener process measurement errors given based concept first hitting time fht percentiles performance degradation failure time distribution ftd also obtained finally comprehensive simulation study accomplished demonstrate necessity incorporating measurement errors degradation model efficiency proposed model two illustrative real applications involving degradation carbon film resistors wear sliding metal given comparative results show constructed approach derive reasonable result enhanced inference precision elsevier ltd rights reserved
cilia arose early eukaryotic evolution structural components highly conserved simplest protists complex metazoan species recent years role cilia ontogeny vertebrate organs received increasing attention due staggering correlation human disease dysfunctional cilia particular presence cilia developing mature kidney become deep area research due ciliopathies common kidney polycystic kidney disease pkd interestingly mutations genes encoding proteins localize cilia cause similar cystic phenotypes kidneys various vertebrates suggesting essential role cilia kidney organogenesis homeostasis well importantly genes far identified kidney disease conserved functions across species whose kidneys include primary motile cilia aim provide comprehensive description cilia role kidney development well highlight usefulness zebrafish embryonic kidney model understand function cilia kidney health
increasing pressure commercial interests obtain radio bandwidth terrestrial satellite radio communication applications existing civil radio navigation military radio location bands scrutinised interests background paper pressures factors marine navigators need aware need deal future
incentive schemes formed regulatory administrative instruments measures promote green building increase motivation developers meet higher standards hidden costs different stakeholders transaction often ignored understanding hidden transaction costs tcs helps appraise costs benefits policy effectiveness example gross floor area gfa concession scheme used systematically explore understand fundamental issues tcs typology chronology development process gfa concession scheme popular incentive due indirect compensation developers allowing additional floor area without expenditure government implement gbs tcs framework used critically review evaluate costs benefits gfa concession scheme particular implementation hong kong singapore explored hong kong used case study complemented depth expert interviews gfa concession hong kong key contribution establish parameters estimating optimum gfa bonus could motivate various stakeholders minimize negative impacts built environment future
introduction emergency department benchmarking alliance summit first time participants recommended tracking nursing advanced practice nurse hours performance data centers medicare medicaid services provides opportunity analyze factors associated delays emergency care purpose study investigate hospital characteristics associated time diagnostic evaluation massachusetts emergency departments methods covariates significantly correlated time diagnostic evaluation factors associated timely care emergency departments included stepwise linear regression analysis differences nurse staffing performance measures trauma nontrauma emergency departments examined analysis variance tests results two predictors explained variance time diagnostic evaluation nurse staffing trauma centers trauma centers time diagnostic evaluation significantly increased minutes nurse cared fewer patients hours minutes nurse cared patients hours discussion efforts improve patient flow often focus process interventions improved utilization observation beds transfers patients inpatient units study time diagnostic evaluation significantly increased emergency nurses care higher numbers patients findings present new evidence identifying relationship specific nurse patient ratios wait time emergency departments
research bullying highlighted role morality explaining different behavior students bullying episodes however research limited analysis explicit measures moral characteristics moral reasoning whereas implicit measures yet fully considered overcome limitation study investigated association bullying defending one hand explicit moral disengagement self importance moral values implicit immediate affect toward moral stimuli iams moral components hand young adolescents mean age years months girls completed series self report scales individually performed computer task investigating iams two hierarchical regressions bootstrapping method performed results showed moral disengagement associated bullying defending behavior high levels iams however iams low contrast self importance moral values significantly associated two behaviors iams high whereas associations significant low levels iams results significantly expand previous knowledge role morality bullying defending behavior particular highlight role interaction explicit implicit moral dimensions predicting bullying defending behaviors society study school psychology published elsevier ltd rights reserved
background obesity reached epidemic proportions around world effectiveness hormonal contraceptives may related metabolic changes obesity greater bodymass body fat hormonal contraceptives include oral contraceptives ocs injectables implants hormonal intrauterine contraception iuc transdermal patch vaginal ring given prevalence overweight obesity public health impact effect contraceptive efficacy could substantial objectives examine effectiveness hormonal contraceptives preventing pregnancy among women overweight obese versus women lower body mass index bmi weight search methods august searched studies pubmed medline central popline web science clinicaltrials gov ictrp examined reference lists pertinent articles identify studies initial review wrote investigators find additional published unpublished studies selection criteria study designs eligible study could examined type hormonal contraceptive reports contain information specific contraceptive methods used primary outcome pregnancy overweight obese women must identified analysis cutoff weight bmi data collection analysis two authors independently extracted data one entered data revman second verified accuracy main comparisons overweight obese women women lower weight bmi examined quality evidence using newcastle ottawa quality assessment scale available included life table rates also used unadjusted pregnancy rates relative risk rate ratio results provided dichotomous variables computed odds ratio confidence interval main results studies added update met inclusion criteria total women focus studies provided high moderate low quality evidence show higher pregnancy risk among overweight obese women five coc studies two found bmi associated pregnancy different directions containing norethindrone acetate ethinyl estradiol pregnancy risk higher overweight women bmi versus bmi versus nonobese women bmi trial tested transdermal patch containing levonorgestrel within patch group obese women treatment compliant subgroup higher reported pearl index nonobese women versus five implant studies two examined six capsule levonorgestrel implant showed differences pregnancy weight one study showed higher weight associated higher pregnancy rate years combined reported pregnancy rates differed year among lower weight groups reported involve women weighing analysis data contraceptive methods indicated association pregnancy overweight obesity included depot medroxyprogesterone acetate subcutaneous levonorgestrel iuc two rod levonorgestrel implant etonogestrel implant authors conclusions evidence generally indicate association higher bmi weight effectiveness hormonal contraceptives however found studies contraceptive methods studies using bmi rather weight alone provide information whether body composition related contraceptive effectiveness contraceptive methods examined among effective used according recommended regimen considered overall quality evidence low objectives review recent reports provided evidence varying quality quality generally low older studies many trials quality would higher original purpose rather non randomized comparisons investigators consider adjusting potential confounding related bmi contraceptive effectiveness newer studies included greater proportion overweight obese women helps examining effectiveness side effects hormonal contraceptives within groups
background exercise beneficial depression less known impact post intervention physical activity sedentary behavior aim paper determine extent participation light moderate vigorous intensity exercise intervention influenced habitual physical activity sedentary behavior patterns depressed adults methods accelerometer data collected pre post intervention depressed participants randomized one three week intervention groups light moderate vigorous exercise mixed models examined changes time spent sedentary light moderate vigorous physical activity mvpa time accumulated sedentary mvpa bouts number mvpa bouts interruptions sedentary time results overall sedentary time decreased light activity time increased across intervention groups significantly light exercise intervention group reduced mvpa minutes time mvpa bouts number activity bouts moderate exercise intervention group reduced time mvpa bouts number sedentary interruptions changes observed vigorous exercise intervention group conclusions exercise intervention led increase overall light physical activity decrease sedentary time though neither change statistically significant participation light moderate exercise intervention groups associated reductions time mvpa bouts evident vigorous exercise intervention group authors published elsevier ltd
generalized spatial modulation gsm spectral energy efficient multiple input multiple output transmission technique low complexity detection algorithm design near maximum likelihood performance receiver challenging focus letter specific exploit fixed sparsity constraint transmitted gsm signals take advantage bayesian compressive sensing bcs sparse signal recovery new detection algorithm referred enhanced bayesian compressive sensing ebcs proposed features complexity reduction high signal tonoise ratios compared ordered blocked minimum meansquared error algorithm furthermore shown simulation error performance comparable algorithm performance gap negligible many cases
influence sand placement method geotextile layer interface shear strength behavior investigated seven different types woven nonwoven geotextiles used poorly graded sand investigation involved placement sand layer inclined horizontal plane different angles step constitutes fundamental step assessing soil deposited different plane therefore different internal soil fabric interface shear strength evaluated using direct shear test although investigated soil uniform poorly graded sand influence deposit plane significant especially non woven geotextile differences soil interface shear strength associated tested geotextile samples show samples higher mass per unit area opening sizes higher interface friction angle regardless bedding plane
women experience gender based violence gbv increased risk hiv better understand causal mechanisms qualitative interviews conducted african american women reported recent gbv recruited areas atlanta deemed high risk hiv infection women tested chlamydia gonorrhea trichomoniasis key themes history abuse stereotypical gender roles concurrency social support hiv prevention programs need address societ cultural relational influences play role men perpetrating gbv also addressing risk protective factors women engage safer sex
nosql especially graph databases constantly gaining popularity among developers promise deliver superior performance handling highly interconnected data compared relational databases apache shindig reference implementation opensocial highly interconnected data model however relational database back end paper describe experiences graph database neoj back end compare cypher gremlin java alternatives querying data mysql consider performance well usability developer perspective results show cypher good query language terms code readability moderate overhead queries however supplemented stored procedures make performance deficits pattern matching queries restful api unusable slow whereas websocket connection performs significantly better elsevier inc rights reserved
paper presents first pixel detector realized using bcd technology stmicroelectronics bcd process bipolar cmos dmos devices mainly targeted automotive application silicon particle detector realized pixel sensor diode dimension support signal sensitivity pixel diode circuit simulations performed substrate voltage analog signal processing circuitry digital operation circuit designed supply voltage moreover analog processing part pixel detector circuit confined unit pixel diode sensor achieve fill factor first phase design array pixels passive diodes designed measured experimentally entire analog circuitry including passive diodes implemented single chip chip tested experimentally voltage capability evaluate suitability sensor omega resistivity substrate characterized laboratory cmos sensor realizes depleted region several tens micrometer characterization shows uniform breakdown irradiation approximate capacitance reverse bias voltage response ionizing radiation tested using radioactive sources ray tube
background potentially early onset hereditary angioedema hae requires special knowledge also infancy early childhood children families hae diagnosis confirmed refuted early difficult studies childhood hae diagnostic approaches limited aim investigate entire danish cohort children hae non hae children hae patients diagnostic approaches clinical characteristics results included children hae non hae hae children symptomatic median age onset years first attack peripheral children abdominal children one first attacks upper airways children less one attack per month symptomatic children treated tranexamic acid inhibitor concentrate unlike countries androgens used pediatric cohort home therapy inhibitor concentrate established cases children trained self administration children treated parents children diagnosed symptoms including without family history median age diagnosis among children years children hae diagnosed refuted symptoms blood samples children complement values investigated cases genetic testing added complement measurements children recently investigated genetic testing first choice cord blood used complement measurements children genetic testing children results complement measurements equivocal several cases especially cord blood samples sensitivity low complement diagnosis hae conclusions investigated clinical characteristics danish children hae rate home therapy high androgens avoided complement values often equivocal especially cord blood samples consequently changed diagnostic practice early genetic testing children family mutation known
aim present study explore patients experiences participating self admission program specialist eating disorders clinic sixteen adult program participants diagnosis anorexia nervosa interviewed months experiences self admission program qualitative content analysis approach applied identify recurring themes four themes identified agency flexibility functions barriers applicability participants used self admission boost healthy behaviors prevent deterioration forestall need longer periods hospitalizations get break overwhelming demands quick access brief admissions provides safety net increase feelings security everyday life even patients actually make use opportunity self admit also provided relief participants relatives furthermore participants experienced self admission may foster agency motivation however model also requires certain level maturity encouraging environment overcome barriers could otherwise hinder optimal use ambivalence asking help informants experienced self admission could allow gain greater insight disease process take greater responsibility recovery transform health care crisis driven proactive offering shift perspective help seeking participation self admission may potentially strengthen participants internal responsibility treatment promote partnership treatment
high order curvature compensated bandgap reference bgr low temperature coefficient proposed paper curvature compensation maintained use pplus poly resistor nplus poly resistor achieve temperature dependent resistor ratios resistor structure adopted enables bgr work low supply voltage high mosfet threshold voltage reduce mismatches transistors resistors design implemented cmos technology supply output reference voltage shows ppm degrees temperature range degrees degrees high gain operational amplifier used enhances power supply rejection ratio khz effect mismatch proposed bgr achieves line regulation total power consumption
introduction patients mild cognitive impairment mci may make suboptimal decisions particularly complex situations could due temporal discounting tendency prefer immediate rewards delayed larger rewards present study proposes evaluate intertemporal preferences mci patients compared healthy controls method fifty five patients mci healthy controls underwent neuropsychological evaluation delay discounting questionnaire evaluates three parameters hyperbolic discounting percentage choices delayed later rewards response consistency acc results significant differences found delay discounting questionnaire mci patients controls three reward sizes considered small medium large using parameters also differences response consistency acc two groups conclusions patients mci perform similarly healthy controls delay discounting task memory deficits notably affect intertemporal preferences
background parental warmth strong influence child development may precede onset psychiatric disorders children interconnected family processes coercive discipline may also influence development psychiatric disorders children prospectively examined association child psychiatric disorders anxiety major depression disorder adhd disruptive behavior disorders course three years among puerto rican youth beyond influence family factors methods boricua youth study participants puerto rican children years age wave living south bronx new york san juan canguas followed three consecutive years youth psychiatric disorders measured diagnostic interview schedule children disc generalized linear mixed models tested association wave psychiatric disorders next two years adjusting demographic characteristics family processes results higher levels related lower odds child anxiety major depressive disorder time respectively strength association adhd disruptive behavior disorder declined time although still significant last assessment respectively unique influence psychiatric disorders beyond influence parenting family processes stronger associations observed among girls depression adhd conclusions incorporating behaviors acceptance support comforting interventions focused parenting skills may help prevent child psychiatric disorders published elsevier ltd
purpose investigation examine discrepancies among three informants adolescents mothers observers reports maternal consulting regard peer relationships relation discrepancies four social adjustment variables prosocial behavior loneliness positive friendship quality physical victimization ethnically diverse sample early adolescents female mothers participated multimethod investigation adolescent reports parental consulting mother observer reports significantly associated adolescent reports four psychosocial outcomes recognizing comparison equivalent regression models inform interpretations data monomethod associations found study article describes discusses strategy analyzing data multiple informants associations adolescent reports parental consulting loneliness physical victimization could fully explained terms adolescent bias systematic variance uniquely associated adolescent reports prosocial behavior positive friendship quality could view discrepancies mother adolescent reports parental consulting reflect poor relationship quality appeared applicable models positive friendship quality somewhat applicable models prosocial behavior physical victimization applicable models loneliness view discrepancies might reflect normative adaptive autonomy supported addition adding understanding maternal consulting regard peer relationships also hoped analytic approach developed study stimulate developments research uses multiple informants
production management evaluate terms performance quantity quality balance different dynamic complex indicators production necessary engineers production managers order capture correct decisions short time according actual socio economic system reason paper presents new approach performance indicators production management analysing mechanical manufacturing system paper focuses cross boundary involving classical manufacturing engineering investigational domain close proximity study employ indicators evaluate production results production optimization performances multifaceted field
recent years model predictive control mpc successfully used control power electronics converters different topologies different applications mpc offers many advantages traditional control techniques ability avoid cascaded control loops easy inclusion constraint fast transient response hand controller computational burden increases exponentially system complexity may result unfeasible realization modern digital control boards paper proposes novel distributed mpc dmpc able achieve performance classical mpc reducing computational requirements implementation proposed control approach tested converter back back configuration used power flow management simulation results provided validated experimental testing several operating conditions
indoor evacuation systems needed rescue safety management one challenges provide users personalized evacuation routes real time end project aims exploring possibilities google glass technology participatory multiagent indoor evacuation simulations participatory multiagent simulation combines scenario guided agents humans equipped google glass coexist shared virtual space jointly perform simulations paper proposes architecture participatory multiagent simulation order combine devices google glass smartphones agent based social simulator indoor tracking services
introduction patellar dislocation emergency vertical patellar dislocation rare often seen adolescents mostly due sports injuries high velocity trauma cases reported literature closed open reduction general anesthesia often needed report case vertical locked patellar dislocation year old male reduced simple closed method spinal anaesthesia literature review regarding various methods treatment also discussed case presentation year old male experienced trivial accident descending stairs sustaining patellar dislocation closed method reduction attempted using simple technique reduction confirmed postoperative rehabilitation started follow uneventful conclusions vertical patellar dislocations encountered rarely emergency department adolescents victims high velocity trauma essential cause unnecessary manipulation avoided closed reduction method simple surgeon prepared open reduction
parkinson disease common movement disorder associated elderly symptomatic therapies effective treatment preventive measures sirtuins pharmacological activators inhibitors associated range neuroprotective effects large body work sirtuins influence pathology accumulated past decade evidence sirtuins activities modifiers pathology mammalian sirtuin paralogues may conflicting impacts pathogenesis disease progression reviewed possible cellular molecular mechanisms underlying sirtuin activities discussed light current knowledge reference autophagy mitochondrial homeostasis microtubule dynamics wiley periodicals inc
major depressive disorder mdd associated disrupted relationships partners family peers problems precipitate onset clinical illness influence severity prospects recovery investigated whether individuals recovered depression use interpersonal signals form favourable appraisals others social partners twenty recovered depressed adults adult episode mdd euthymic medication free six months healthy never depressed adults completed task gaze direction faces reliably cued location target valid faces whereas faces cued opposite location invalid faces participants reported awareness contingency groups significantly faster categorise targets following valid compared invalid gaze cueing faces following task participants judged trustworthiness faces whereas healthy never depressed participants judged valid faces significantly trustworthy invalid faces implicit social appraisal absent recovered depressed participants individuals recovered mdd able respond appropriately joint attention people appear use joint attention form implicit trust appraisals others potential social partners
paper provides overview technical study satellite radio interfaces based gpp wcdma system first outcome technical study introduced carried mobile satellite system working group etsi satellite earth satellite technical committee etsi ses mss study dealt configurations performance gpp wcdma utran radio interface satellite link second evolution satellite specific radio interface study results addressed possible adaptations wcdma satellite link order maximize radio link performance resultant outcome study reflected detail families satellite radio interface itu recommendation respectively copyright john wiley sons ltd
installation free falling jet grade control structures become popular choice river bed stabilization however formation development scour downstream structure may lead failure structure current approaches scour depth prediction generally based studies conducted absence upward seepage present study effects upward seepage scour depth investigated total tests without application upward seepage carried using three different sediment sizes three different tailwater depths four different flow discharges four different upward seepage flow discharge rates tests three dimensional components flow velocity within scour hole measured cases without upward seepage scour depth measured seepage results compared well accurate relationship found literature found generally upward seepage reduced downward velocity components near bed led decrease maximum scour depth maximum scour depth reduction found minimum tailwater depth small sediment size high flow discharge decay downward velocity vector within jet impingement found due upward seepage flow velocity well known equation agostino ferro modified account effect upward seepage satisfactorily predicted experimental scour depth reasonable average error
timely correctly evaluating quality global positioning system gps data essential reduction number false alarms missed detection gps based bridge deformation monitoring system paper investigates use statistical process control technique known cumulative sum cusum chart detection small persistent shifts high rate gps carrier phase measurements first mathematical model shift detection based continuous hypothesis testing established main features implementation procedure cusum chart shift detection summarized corresponding parameter selection method discussed detail meet normality requirement cusum chart novel method transfers data statistic estimated cumulative distribution functions proposed according probability integral transform theory followed simulation carried evaluate detection performance cusum chart exploit advantages commonly used shewhart chart high rate gps monitoring data different shift sizes experimental results showed cusum chart sensitive small persistent shifts compared shewhart chart although delay problem integration cusum chart shewhart chart would reliable approach shift detection finally site dynamic monitoring experiment carried long span bridge validate proposed approach effectiveness detecting actual deformation shift experimental results proved encouraging
background persistent organic pollutants represent industrial sector effluents egypt contamination river nile water various pesticides poses hazardous risk human environmental compartments therefore large scale monitoring study carried pesticides pollution three geographical main regions along river nil water stream egypt methods organochlorine organophosphorus pesticides extracted liquid liquid extraction analyzed ecd results organochlorine pesticides mean concentrations along river nile water samples endrin dieldrin ddd ddt dde respectively dieldrin ddt dde standard guidelines world health organization detected organophosphorus pesticides triazophos quinalphos fenitrothion ethoprophos chlorpyrifos ethion fenamiphos pirimiphos methyl toxicity characterization organophosphorus pesticides according water quality guidelines indicated hazardous risk detected chemicals public different environmental compartments spatial distribution patterns detected pesticides reflected reverse relationship regional temperature organochlorine pesticides distribution however organophosphorus distributed according local inputs pollutant compounds conclusions toxicological water quality standards data revealed hazardous risk detected pesticides egyptian river nile water human aquatic life thus monitoring data provide viewpoints stricter legislation regulatory controls admitted avoid river nile pesticide water pollution
paper uses idea charismatic gap help explain disjuncture burden disease attributable noncommunicable diseases ncds global south tendency view something esoteric distraction pressing concerns global health hiv aids malaria vaccination maternal health livingston improvising medicine african oncology ward emerging cancer epidemic durham duke university press ncds composite category cardiovascular disease respiratory diseases cancer diabetes grouped together virtue four shared risk factors tobacco alcohol unhealthy diets sedentarism infectious diseases spread viruses bacteria conditions contagion provoke fear disgust suspicion irrationality amid physical suffering high mortality rates ncds often met ennui paper draws concept charisma help explore explain neglected epidemic ncds global south four themes lexicon used describe frame communicate ncds risk factors culpability temporality disease embodiment conclusion paper reflects activate latent charismatic potential ncds global south
purpose study aims provide methodology constructing farm household level adaptation metrics agriculture water sectors livelihood farm households risk foreseeable future agriculture water sectors vulnerable climate variability particularly developing nations adaptation critical protect livelihood vulnerable farmers adopted various adaptation mechanisms counteract negative impacts climate variability though extent varies temporally spatially design methodology approach therefore imperative understand current adaptation practices successfully implementing studies emerged far context investigating different issues associated micro level adaptation strategies related agriculture water sectors output cost effectiveness constraints related farm household institutional levels findings analysis critical enhance micro level adaptation measures felt need formulate adaptation metrics investigate underlying factors integrated manner empirical assessment farmers interviewed different agro ecological zones tamil nadu india regarding seven adaptation measures micro irrigation rainwater harvesting resistant crops use bio fertilisers crop insurance income diversification community based efforts practical implications adaptation measures evaluated analytical hierarchy process using four criteria effective awareness economic viability individual institutional compatibility flexibility independent benefits originality value present study provides methodology identify barriers limit implementation adaptation measures enable target oriented policy measures promote appropriate adaptation strategies local level
pediatric adolescent sports participation increased concomitant increase injuries sports transitioned recreational deliberate structured activities wherein success determined achievement elite status led specialization single sport intensive repetitive activity younger ages causing physical emotional consequences particularly true growing athlete particularly susceptible injury clinicians caring population must understand epidemiology youth sports specialization unique physiology structure age group potential physical emotional consequences
marital quality social support satisfaction tested moderators association maternal depressive symptoms parenting early childhood months among large divergent longitudinal samples unexpectedly samples association maternal depressive symptoms reduced parenting quality strongest context high marital quality high social support largely nonsignificant context low marital quality low social support possible explanations surprising findings discussed results point importance accounting factors broader family context predicting association depressive symptoms maternal parenting
background suture button repair widely accepted surgical treatment acute isolated ankle syndesmosis injuries knowledge midterm results previously reported purpose evaluate clinical qualitative quantitative radiological midterm outcomes suture button repair acute isolated ankle syndesmosis injuries study design retrospective case series level evidence methods clinical outcomes measured using foot ankle disability index fadi american orthopaedic foot ankle society aofas score three tesla magnetic resonance imaging mri performed bilaterally ankle besides morphological sequences evaluation syndesmosis degenerative changes ankle using ankle osteoarthritis scoring system aoss protocol included coronal dimensional multislice multiecho sequence quantitative cartilage weighted mapping spearman correlations paired tests used statistical analysis results retrospective study included consecutive patients mean age years acute isolated syndesmosis injuries treated suture button system january june mean follow years postoperatively median fadi score range median aofas score range seventeen patients reported reached preinjury level sports activities mris patients obtained showed intact anterior posterior syndesmotic ligaments however patients previously injured syndesmotic ligament thickened compared uninjured ankle average width anterior posterior syndesmosis significantly different ipsilateral contralateral ankles median aoss score range ipsilateral ankle range contralateral ankle values articular cartilage significantly differ involved uninjured ankle five patients needed hardware removal due persistent skin irritation patient suffered reinstability ankle resulting revision surgery years index surgery conclusion suture button fixation excellent treatment acute isolated syndesmosis injuries resulting stable ankles without early advanced osteoarthritic changes midterm follow
three key drivers change world software identified impact range software engineering research assessed rise agile approaches software development adds pressure software process research develop evolve processes supportive change meeting stringent needs society two examples successful process evolution aimed highly regulated industries outlined pointers future direction software process research copyright john wiley sons ltd
background although mental health overall strongly associated psychological distress association weak sample high relationship remains understudied aim study examines association whether association mediated social network factors individuals high method data taken household income labour dynamics australia study measured using sub scale general health survey short form measured using kessler psychological distress scale measures derived self completion questionnaire using bootstrap mediation analysis tested whether association mediated factors result correlation mediational analysis results show social isolation mediates association indirect effect confidence interval moreover social connections also mediated association indirect effect conclusion study practical implications design social policies attempt reduce social isolation enhance social connectedness protect
postpartum obese women increased risk breastfeeding difficulties depression retaining pregnancy weight months postpartum predicts long term obesity risks weight retention include excessive gestational weight gain ethnicity socioeconomic status diet exercise depression duration breastfeeding exercise reducing total caloric intake promote postpartum weight loss intrauterine devices contraceptive implants effective contraceptives obese women contraceptive pills patches vaginal rings effective options however obese women made aware potential increased risk venous thromboembolism vasectomy hysteroscopic sterilization carry least surgical risk obese women
purpose authors currently developing dual resolution multiple pinhole microspect imaging system based three large nai gamma cameras two multiple pinhole tungsten collimator tubes used sequentially whole body scout imaging mouse followed high resolution res imaging organ interest heart brain ideally whole body image reconstructed real time data need acquired area interest visualized well enough determine positioning res scan authors investigated utility origin ensemble algorithm online offline reconstructions scout data algorithm operates directly image space provide estimates image uncertainty along reconstructed images techniques accelerating reconstruction also introduced evaluated methods system matrices calculated pinhole scout collimator design spect projections simulated range count levels using moby digital mouse phantom simulated data used comparison maximum likelihood expectation maximization mlem reconstructions algorithm convergence evaluated calculating total image entropy measuring counts volume interest voi containing heart total image entropy also calculated simulated moby data reconstructed using various levels parallelization results voi measurements heart liver bladder soft tissue mlem reconstructed images agreed within image entropy converged similar iterations counts heart converged earlier similar iterations accelerated version completed iterations min count data set loss image entropy performance whereas dataset required similar min complete iterations conventional combination two methods showed decreased reconstruction time loss performance compared conventional alone conclusions reconstructed images found quantitatively qualitatively similar mlem yet also provided estimates image uncertainty acceleration reconstruction gained use parallel computing algorithm useful reconstructing multiple pinhole spect data easily modified real time reconstruction american association physicists medicine
whole world evolving fast course technology innovated quickly well vision main theme conference said sounds like far future five years long time nevertheless technical possibilities increasing dramatically necessary think future plan future vision whole process starts education young innovative people effective choice employer meet objectives rapidly need necessary education new models intense focus student experience drive innovation entrepreneurism ensure higher education continues meet society needs educase important students deal real problems studies projects coming local companies students must high quality study materials come real projects industry students would study engineering without expecting education help prepare engineering work male sometimes see lectures supported twenty year old materials necessary change takes graduates technical faculties months years able work independently beneficial society efficiency education low level
bereavement literature proliferated recent decades generating shift conceptualizing grief stepwise uniform process idiosyncratic experience varies among individuals among notable developments empirical exploration complicated grief protracted debilitating sometimes life threatening response death loved one testing novel interventions treat article provides counselors recommendations identifying treating complicated grief
using insights case study allocation labor subsistence households mozambique study develops conceptual framework examining linkages time poverty farm production unexpected event health crisis increases demand labor provided women thus making time poor model numerical simulations show deterioration woman time constraint adverse effect agricultural output household occurs women respond increase household work reducing work hours farm reducing leisure time latter outcome expected negative effect women physical mental health cause decline productivity farm
background dysfunctional cognitions regarding weight shape implications self esteem considered core features anorexia nervosa bulimia nervosa however also associated severity binge eating disorder bed therefore screened appropriate instruments tailor treatment individual patient needs mizes anorectic cognitions revised mac self report questionnaire lists dysfunctional cognitions related three hypothesized core beliefs typical psychopathology eating disorders weight eating basis approval others belief rigid self control fundamental self worth rigidity weight eating regulation efforts objectives goal study confirm factor structure assess validity mac among sample met full threshold subthreshold criteria bed methods used data women meeting full threshold subthreshold criteria bed conduct confirmatory factor analyses compute spearman correlations order assess factorial convergent discriminant validity results two models structure three factors without total score proved acceptable mac total score correlated questionnaires assessing dimensions related eating disorder psychopathology adding validity questionnaire conclusion results similar found studies psychometric properties mac among samples anorexia nervosa bulimia nervosa encouraging use mac research clinical tool order document core beliefs underlying bed
paper focuses field ontology evaluation visualization ontologies represent essential technology development semantic web applications technology proven useful range applications data manipulation administration paper introduces ontology visualization approach based descriptive vectors offers design descriptive vectors representation ontology domain also algorithm design generation descriptive vectors approach offers quick overview given ontologies content addition work presents design methods comparison evaluation various ontologies based descriptive vectors moreover introduces method ontology placing context within ontological space map finally method administration user navigation ontological space presented
employment interviews relevant scenarios study social interaction setting social skills play important role even though interactions potential employers candidates often limited one fundamental aspect social interaction use nonverbal communication affects socially perceived present method automatically extract body communicative cues one one conversations recorded kinect devices first find three dimensional position hands head subject aided training data infer upper body pose use inferred poses perform action recognition build person specific activity descriptors evaluate system domain specific public generic datasets show competitive performance
lies deceptions prevalent daily lives yet people merely guess attempting distinguish lies truths current research examined validity saying takes thief know thief showing takes good liar one high attachment insecurity detect another liar study card players participated bullshit tournament card game players try deceive players also striving detect deceptions study people cheated romantic partner versus asked detect cues infidelity results confirmed expectations showed good liars cheaters usually insecure individuals better detecting lies dishonesty results discussed perspective social defense theory highlighting utility personality traits often deemed maladaptive elsevier ltd rights reserved
paper considers problem determining robust pid proportional integral derivative controllers terms gain phase margins gpm open loop unstable first order plus time delay ufoptd processes first time feasible ranges gpm specifications provided pid controller given ufoptd processes gain phase margin tester used modify original model ranges margin specifications derived modified model stabilized stabilizing pid controller based hermite biehlers theorem furthermore obtain controllers satisfying given margin specification simulation studies show use results design robust pid controller isa published elsevier ltd rights reserved
purpose reviewin review discuss current thinking relation available guidelines care preschool aged children recurrent wheezing highlighting gaps knowledge discussing changes could occur next years recent findingsthe asthma predictive index well allergen specific ige peripheral eosinophil count exhaled nitric oxide perhaps underutilized sources information assist predicting progression asthma response therapies inhaled corticosteroids leukotriene receptor antagonists decrease impairment exacerbation frequency wheezing children disease modifying macrolides may useful acute wheezing episodes preventing progression severe symptoms monoclonal antibodies targeting ige cytokines successful trials adults older children asthma trials younger children needed summaryestablishing phenotype endotype young wheezing children useful prognostication future asthma risk well selection appropriate treatment primary asthma prevention strategies needed critical developmental window early life prior onset irrecoverable loss lung function
denial service dos attack purely malicious commonly used overwhelm network system making network resources unavailable legitimate users one dos attack target firewall system enterprise whereby attacker sends large number malicious packets firewall making unavailable legitimate users launch smart effective dos attack attacker makes priori assumption order ruleset firewall effective firewall reveal ruleset policies information attacker paper first present process used attacker reconnoiter firewall system leisure collect information ruleset target firewall collected information used attacker launch slow rate dos attack firewall propose countermeasure technique delay induced response dir utilizes underlying principle moving target defense cyber maneuver technique dir network frequently changes properties visible attacker order confuse attacker discovering information firewall policy ruleset primary objective dir delude attacker efforts discovering order firewall ruleset specifically last matching rule also known default rule firewall
context currently great tendency cosmetic area use natural extracts coffee silverskin abundant solid product generated roasting coffee processing objectives evaluate different extracts promising cosmetic ingredients regarding antioxidant antimicrobial cytotoxic properties materials methods aqueous hydroalcoholic ethanolic extracts obtained environmentally friendly procedure considering costs pollution extracts characterized total phenolic flavonoid contents tpc tfc respectively antioxidant activity diphenyl picrylhydrazyl dpph ferric reducing antioxidant power frap antimicrobial activity expressed minimal inhibitory concentration mic cytotoxicity using dimethylthiazol carboxymethoxyphenyl sulfophenyl tetrazolium mts lactate dehydrogenase ldh assays two skin cell lines fibroblasts keratinocytes results tpc extracts gallic acid equivalents per material dry basis gae tfc extracts cathechin equivalents per dry material antioxidant activity high values ranging mol aqueous alcoholic samples respectively preliminary assays antimicrobial potential showed extracts display antibacterial activity mic varied gram positive gram negative extracts affect vitro cell viability values near concentrations tested conclusion results seem show safe source natural antioxidants antifungal antibacterial activity cytotoxicity potential usefulness cosmetic applications
work describes mentorship experience mentorship novice teachers experienced teachers important aspect training teachers universities strategy followed work consisted double improvement cycle clinical supervision cycle based use recordings classes cycles included planning recording viewing analysis conclusions reached final meeting video analysis order systematize viewing analysis assessment videos observation test employed class planning contents methodology verbal nonverbal communication skills evaluated using test
health care workers community mental health alcohol drugs aod sectors face complex psychological issues exact heavy emotional toll burnout significant risk workers stress management developing effective work practices implementation burnout interventions crucial engaging retaining staff present study non randomized investigates effects targeted week emotion regulation mindfulness training program ceb educators mental health workers participants completed ceb training demonstrated significant improvement mindfulness significant increase emotional awareness compared control group assessments made baseline directly training ceb trained group months post training completion change persisted months completing training results suggest embedding ceb training within higher education curriculum may long term positive impact students health care workers planning enter aod sector research required elsevier ltd rights reserved
interferon ifn associated development thrombotic microangiopathy including thrombotic thrombocytopenic purpura ttp hemolytic uremic syndrome hus reviewed literature earliest reported association july found cases analysis data shows mean age diagnosis years majority cases seen ifn used treatment chronic myelogenous leukemia cml multiple sclerosis chronic hepatitis virus infection hcv one case hairy cell leukemia hcl sezary syndrome cases reported polycythemia vera lymphoma sex distribution nearly equivalent exception patients multiple sclerosis female predominance reported data pooled analysis average duration treatment ifn tma diagnosed months comparative analysis showed patients required highest cumulative dose exposure developing tma months cml months hcv months cases confirmed ttp disintegrin metalloprotease thrombospondin type motif adamts level measured showed presence inhibitor cases confirmed ttp moderate severe thrombocytopenia striking clinical feature presentation consistent finding cases tma outcome analysis revealed complete remission persistent chronic kidney disease ckd fatality patients treatment corticosteroids plasma exchange rituximab resulted durable responses elsevier rights reserved
controlling complex mechanical systems often difficult task requiring skilled developer experience control engineering practice however theoretical difficulties designing good controller first step implementation various pieces equipment also often challenging paper investigates iterative learning control ilc used alternative tuning existing controllers improving system performance evaluated case study high speed positioning system used laser cutting ilc algorithm implemented using server client structure matlab tuning parameters implementation found able increase tracking accuracy significantly cutting speeds done implementing code master control unit thus without changing subsystem controllers
mechanical response multiphase alloys governed microscopic strain stress partitioning behavior among microstructural constituents however due limitations characterization partitioning takes place submicron scale microstructure optimization alloys typically based evaluating averaged response referring example macroscopic stress strain curves novel experimental numerical methodology introduced strengthen integrated understanding microstructure mechanical properties alloys enabling joint analyses deformation induced evolution microstructure strain stress distribution therein submicron resolution experiments deformation induced evolution microstructure local strain distribution concurrently captured employing situ secondary electron imaging electron backscatter diffraction ebsd former microscopic digital image correlation latter simulations local strain well stress distributions revealed full field crystal plasticity simulations conducted advanced spectral solver suitable heterogeneous materials simulated model designed directly initial ebsd measurements phase properties obtained additional inverse simulations nanoindentation experiments carried original microstructure experiments simulations demonstrate good correlation proof principle study conducted martensite ferrite dual phase steel deviations discussed terms limitations techniques involved overall presented integrated computational materials engineering approach provides vast amount well correlated structural mechanical data enhance understanding well design capabilities multiphase alloys acta materialia inc published elsevier ltd rights reserved
rainwater harvesting ancient practice involves collecting storing using precipitation meet site water needs paper develops demonstrates guidelines sizing capacity storage tanks provide reliable continuous supply harvested rainwater residential households operation rainwater harvesting system simulated stochastic mass balance performed excel spreadsheet daily volume rainwater unbounded tank tracked determine maximum accumulated deficit monthly basis results summarized dimensionless charts showing minimum size rainwater storage tank needed meet water demands specified levels reliability authors published elsevier ltd
pyruvate membrane crossing lactate dehydrogenase mediated conversion lactate cells featuring different levels expression membrane monocarboxylate transporters mct probed dissolution dynamic nuclear polarization enhanced nmr hyperpolarized labeled pyruvate transferred suspensions rodent tumor cell carcinoma cell line pyruvate lactate conversion rate monitored dissolution dynamic nuclear polarization nmr carcinoma cells featuring native mct expression level lower rate observed cells human mct gene overexpressed enzymatic activity lactate dehydrogenase also assessed buffer solutions following real time pyruvate lactate conversion speeds different enzyme concentrations copyright john wiley sons ltd
introduction developed world infertility rise become social concern considered serious stress life exerts severe psychological impact couple aim study conducted study efficacy stress management based group cognitive behavioural therapy marital satisfaction infertile women materials methods quasi experimental study pretest post test design control group study sample consisted infertile women enrolled based convenience sampling randomly assigned two groups experimental control experimental group underwent two hour stress management sessions per cognitive behavioural therapy instruments used study marital satisfaction inventory enrich checklist demographic characteristics immediately three months completion intervention instruments administered participants data analysed analysis covariance spss results significant difference marital satisfaction experimental control groups post test follow conclusion stress management based cognitive behavioural therapy could contribute increasing marital satisfaction infertile women effect could remain stable three months last interventions follow
rigid water column rwc models simulate unsteady incompressible hydraulics pressurized pipe networks conceptually lie water hammer quasi steady models yet despite intrinsic strengths existing rwc formulations suffer efficiency stability interpretation related challenges thus typically overlooked modeling alternative address aforementioned limitations article presents rwc global gradient algorithm gga novel formulation pipe networks greater efficiency overcomes numerical challenges rwc gga extends generalized gga gga consider inertial effects addition variable area tanks mixed demand pressure dependent outflows two pipe networks simple moderate complexity used compare new approach two rwc algorithms gga water hammer model current work shown improved stability efficiency relative previous work rwc gga also found computational cost slightly greater gga time step size overall work highlights practical utility rwc models simulate slow transient events controlled operations
background preoperative disinfection povidone iodine results significant reduction risk postoperative endophthalmitis secondary irreversible vision loss intraocular surgeries intravitreal injections nevertheless important measure often omitted called iodine allergy suspected analyze physiological allergological basis construct iodine allergy methods article based selective literature review using search term allergy combination iodine povidone indocyanine green seafood results iodine chemical element essential component human body scientific proof existence antibody mediated allergic reaction type reaction particular immunoglobulin mediated anaphylaxis iodine lacking chemical irritations contact allergies type reaction induced iodine containing disinfectants antibody mediated cause anaphylaxis type reaction uncommon antibody mediated allergies iodine containing disinfectants fluorescent dyes radiocontrast media seafood directed contained iodine components respective formulation thus allergic cross reactivities different substance groups expected conclusion called iodine allergy medical myth lacking scientific basis result increased patient risks due omitted preoperative disinfection
purpose evaluate feasibility outcomes nurse practitioner delivered program targets obesity real world primary care setting method small descriptive study conducted clinic low income patients sixteen adult participants obese attended individual primary care office visits occurring every weeks weeks healthcare provider delivered pre planned behavioral interventions visit data comprised health promoting lifestyle profile hplp additional surveys physical measures results participants reported improvement health responsibility physical activity nutrition spiritual growth stress management motivation healthy living diastolic blood pressure declined systolic blood pressure body mass index declined non significantly conclusion additional research necessary determine success program time larger numbers diverse participants healthcare providers primary care practice sites elsevier inc rights reserved
objective study aimed develop validate contents mosaico opinioes sobre aborto induzido mosai structured questionnaire intended used tool collect information views health professionals morality abortion methods contents first version questionnaire developed based technique thematic content analysis books articles films websites newspapers reporting cases abortion arguing practice mosai composed moral dilemmas vignettes related induced abortion whose outcomes chosen respondents could justified classification patterns arguments morality abortion order validate contents questionnaire submitted scrutiny panel experts intentional sample consisted doctors lawyers ethicists sociologists nurses statisticians evaluated criteria clarity writing relevance appropriateness sample suitability fields scores analyzed method concordance rate free comments analyzed using analysis technique content results moral dilemmas arguments considered valid according rate agreement however comments led exclusion dilemma emergency contraception among changes conclusion content mosai considered valid serve tool collect opinions healthcare professionals regarding morality abortion elsevier editora ltda rights reserved
coal fired power plants produce nearly electricity united states contributing three quarters carbon dioxide emissions electricity sector many european coal fired power plants transitioning wood pellets abate carbon dioxide emissions changeover occurred united states electricity sector analysis examines environmental implications firing coal wood pellets southeastern united states vast majority wood pellet exports europe originate utilizing primary data existing wood pellet manufacturers life cycle inventory presented characterizes full cradle grave environmental performance firing coal wood pellets electricity generation furthermore avoided life cycle emissions related shipping wood pellets europe calculated life cycle assessment modeling scenarios firing wood pellets existing coal fired power plants within southeastern united states result reductions eight nine impact categories results presented indicate firing wood pellets could viable interim solution aging fleet coal fired power plants within southeastern united states particularly stricter emission regulations renewable portfolio standards implemented published elsevier ltd
study cavities channels molecular structure crucial step understanding function biomolecules current tools techniques extracting structural features sensitive uncertainties atomic position radii paper study problem cavity extraction biomolecules taking account uncertainties propose approach connects user specified cavities computing optimal conduit within region occupied molecule conduit computed using topological representation occupied empty regions guaranteed satisfy well defined geometric optimality criteria visualization set cavities multiple linked views serves useful interface interactive extraction stable cavities demonstrate utility proposed method successfully identifying biologically significant pathways molecular cavities using several case studies
among alternative scheduling techniques construction management linear repetitive scheduling line balance lob uniquely different dominant network based technique developed projects repetitive units work crew operations notably feature quantitative measures work time network based approach offers however study origins example navy reveals original use capabilities deviate current application limited best indeed currently name giving lob omitted therefore research goal explore scheduling techniques detail objectives delineate modelling elements described original sources structured manner compare detail identify changes time comment implications practical use extract unsolved research questions methodology follows comparative research approach differences found productivity cyclic crew deployment expressed besides glaring omission lob construction use method found historically lob intended manufacturing introduced construction important characteristics production plan progress chart became forgotten parallel linear scheduling developed construction whose similarities lob may added confusion clarifying complete methods explicitly outlining analytical capabilities improve understanding allow project managers benefit powerful tools also enables future research model lob singularity functions yield unified formulation alternative scheduling techniques
paper address identification class multi input single output miso linear time invariant lti discrete time systems miso system composed several single input single output siso lti systems sum output siso system measured exciting one siso system employing periodic inputs remaining siso systems decompose miso system excited siso system input output calculated measured data original parameters siso system estimated using well established identification techniques proposed method using periodic inputs also extended identification beyond nyquist frequency simulation experimental results identification actuators dual stage hard disk drive carried demonstrate efficacy proposed approach
generally acknowledged people adopt different resolution strategies facing conflicts others however mechanisms conflict resolution still unclear researched particular within context chinese adolescents sex friendship relations thus present study investigated mediator role conflict resolution strategies relationship regulatory foci friendship satisfaction first time chinese adolescents completed regulatory foci conflict resolution style friendship satisfaction measures results structure equation modeling showed promotion focus positively associated problem solving compliance prevention focus positively associated withdrawal conflict engagement addition problem solving mediated relationship promotion focus friendship satisfaction conflict engagement mediated relationship prevention focus friendship satisfaction findings contribute understanding chinese adolescents use conflict resolution strategies well relationship regulatory foci behavioral strategies negative situations
paper brings explicit considerations distributed computing architectures data structures rigorous design sequential monte carlo smc methods theoretical result established recently authors shows adapting interaction particles suitably control effective sample size ess sufficient guarantee stability smc algorithms objective leverage result devise algorithms thus guaranteed work well distributed setting make three main contributions achieve first study mathematical properties ess function matrices graphs parameterize interaction among particles secondly show graphs induced tree data structures model logical network topology abstract distributed computing environment finally present efficient distributed algorithms achieve desired ess control perform resampling operate forests associated trees wiley periodicals inc statistical analysis data mining asa data science journal
aimto compare gel made chamomile chamomilla recutita cream urea intervention delay time occurrence radiation dermatitis backgroundradiation dermatitis one common adverse effects radiotherapy patients head neck cancer characterized erythema itching pain skin breakage burning sensation consensus prevent designthe study randomized controlled clinical trial methodswe recruit individuals head neck cancer starting radiotherapy randomize receive either gel chamomile cream urea intervention prevention radiation dermatitis social demographic data collected baseline clinical data collected initiation radiotherapy participants followed weekly assess development radiation dermatitis protocol funded conselho nacional pesquisa desenvolvimento cientifico brazil study approved research ethics committee discussiongiven clinical relevance preventing radiation dermatitis lack evidence supporting specific preventive interventions important study new products might efficacious prevent complication article presents protocol randomized controlled trial comparing gel made chamomile intervention cream urea control prevent radiation dermatitis patients head neck cancer undergoing radiotherapy
investigated whether juvenile rats express renewal following extinction conditioned fear due inability form long term contextual fear memory experiment postnatal day rats received white noise footshock pairings followed white noise alone presentations next day tested different context extinction rats displayed renewal whereas rats experiments surprisingly showed rats show differences contextual cued fear regardless conditioning test intervals number white noise footshock pairings received finally observed age differences contextual fear rats weaned experiment results indicate developmental dissociation observed renewal extinguished fear related widely believed late emergence contextual fear learning
consider complete communication network nodes synchronous counting nodes receive common clock pulse agree pulses odd even furthermore solution needs self stabilising reaching correct operation initial state tolerate byzantine failures nodes send arbitrary misinformation prior algorithms either require source random bits large number states per node work give fast state optimal deterministic algorithms first non trivial case obtain algorithms develop evaluate two different techniques algorithm synthesis based casting synthesis problem propositional satisfiability sat problem direct encoding efficient synthesising time optimal algorithms approach based counter example guided abstraction refinement discovers non optimal algorithms quickly elsevier inc rights reserved
present paper presents system intended used development photovoltaic inverters maximum power point tracking capability simulation model implemented matlab simulink experimental model composed dspace controller board semikron inverter coupling transformer filter two solar panels developed system facilitates development testing digital control mppt algorithms single phase inverters connected utility grid
propose paper present systematic processes constructing averaged small signal model three phase grid connected three level neutral point clamped inverter lcl filter design control system grid current using model systematic processes composed averaging perturbing linearizing step circuit equations addition paper presents frequency domain analysis design control systems study system stability control scheme grid current based averaged small signal model validity model verified simulation experiments
study examined effect teaching english gestures efl iranian school students achievement speaking forty iranian efl learners participated study opt divided two groups one control group one experimental group two months teaching gestures done experimental group treatment gestures regarded treatment common tools nonverbal communication treatment gestures used determine effect students achievement speaking speaking placement test given experimental group control group pretest posttest according resultsobtained statistical calculations effectiveness treatment noticeable study suggests teaching english gestures effective technique teaching english however help students develop ways overcome communication problems extenr moreover regarded natural responses situations
deep convolutional neural networks dcnns recently emerged dominant paradigm machine learning variety domains however acquiring suitably large data set training dcnn often significant challenge major issue remote sensing domain extremely large collections satellite aerial imagery lack rich label information often readily available image modalities letter investigate use dcnn land cover classification high resolution remote sensing imagery overcome lack massive labeled remote sensing image data sets employ two techniques conjunction dcnn transfer learning fine tuning data augmentation tailored specifically remote sensing imagery allows one bootstrap dcnn preserving deep visual feature extraction learned image corpus different image domain data augmentation exploits various aspects remote sensing imagery dramatically expand small training image data sets improve dcnn robustness remote sensing image data apply techniques well known merced data set achieve land cover classification accuracies caffenet googlenet resnet respectively
background long term clinical outcomes antiviral therapy patients chronic hepatitis uncertain terms hepatitis virus hcv related morbidity mortality according response antiviral therapy study aimed assess impact antiviral treatment development hcc mortality patients chronic hcv infection methods systematic review conducted studies evaluated antiviral efficacy patients chronic hepatitis assessed development hcc mortality svr sustained virologic response non svr patients methodological quality enrolled publications evaluated using risk bias table newcastle ottawa scale random effect model meta analyses meta regression performed publication bias assessed results total studies rcts prospective retrospective cohort studies included antiviral treatment associated reduced development hcc treatment effect intensified svr achieved svr antiviral treatment associated lower cause mortality treatment liver specific mortality rate also intensified svr achieved cause mortality svr liver specific mortality sensitivity analyses revealed robust results small study effect minimal conclusions patients chronic hepatitis antiviral therapy reduce development hcc mortality especially svr achieved
background paper introduces concept deep breathing applications one means towards stress management regulation blood pressure among indian college engineering students underlying concept deep breathing relation emotions breathing two way emotions affect breathing controlled deep breathing also effect emotions objective objective paper find whether deep breathing technique able control blood pressure turn level stress methods sample students selection initial screening students reported high mental stress interview selected main drills readings taken using sphygmomanometer digital blood pressure meter students test used purpose hypothesis testing results results indicated deep breathing technique provided significant results conclusion recommended amazingly simple yet highly effective ancient technique deep breathing become part students routine curriculum paper aims spreading awareness yogic technique one modes stress management amongst indian college students
ratio second fourth digit length correlate prenatal testosterone high associated low prenatal testosterone reduced sensitivity testosterone klinefelter syndrome xxy affects endocrine system low testosterone levels found foetuses new borns adults date published data regarding pattern males consider individuals relatives fathers mothers unaffected control sample men women adult individuals taller fathers shorter fingers fathers male controls compared fathers male controls mothers males shorter fingers relative height regard individuals higher fathers right left hands male controls right left hands mothers left hands among males older years individuals currently prescribed testosterone nine prescribed comparison former latter individuals higher right higher right left conclude males mean values similar found female population norms addition testosterone supplementation males may common individuals low right
paper based equivalent single diode circuit model solar cell equivalent circuit diagram two serial solar cells drawn equations current voltage derived kirchhoff current voltage law first parameters obtained current voltage curves typical monocrystalline silicon solar cells regarding photo generated current shunt resistance serial resistance first solar cell resistance load variables properties shunt currents diode currents load current whole two serial solar cells numerically analyzed four cases first time corresponding physical explanations made find parameters different influences internal currents solar cells results provide reference developing higher efficiency solar cell module contribute better understanding reason efficiency loss solar cell module
elevated excitability hippocampus emerged key contributor reduced memory function aging cognitive impairment prodromal alzheimer disease investigated relationship neural activity memory hippocampus connectional cortical network using aged rat model individual differences memory impairment expression cfos used measure pharmacologically induced neural activity aged memory impaired rats exhibited elevated cfos relative young adult aged unimpaired rats subfield hippocampus several cortical regions including retrosplenial parietal orbitofrontal cortices strong correlations cfos intensity task performance across activated network showed tight coupling excitability cognitive phenotype aging elevated neural excitability extending beyond hippocampus interconnected posterior cortex retrosplenial parietal reduced treatment levetiracetam therapeutic behavioral efficacy previously translated rodent models age related impairment alzheimer disease humans amnestic mild cognitive impairment elsevier inc rights reserved
parents raising safe kids program prsk research based manualized violence prevention curriculum designed decrease coercive parenting behavior encourage positive discipline increase media violence literacy increase child development knowledge study multi site pre post comparison evaluation prsk effectiveness diverse parents including incarcerated drug treatment english spanish speaking results indicate prsk successful improving media violence literacy positive parenting behavior child development knowledge anger management prosocial problem solving additionally prsk especially efficacious spanish speaking participants improved english speakers due need appropriate cost effective programs underrepresented groups results add growing evidence base supporting use prsk diverse parents prsk effective educating caregivers nonviolent parenting behavior child development flexible focuses parents young children cost effective program costs fraction evidence based practices yet statistical effect sizes change time comparable elsevier ltd rights reserved
friction stir welding novel joining process extensively used welding aluminum alloys widely known process parameters involved friction stir welding play pivotal role determining final characteristics microstructure joint however still unclear combination process parameter values lead optimum joint characteristics taguchi technique handy efficient method widely used performing optimization manufacturing engineering paper lap joint friction stir welding performed process parameters optimized using taguchi orthogonal design experiments unlike previous studies optimization friction stir welding process aluminum alloys comprehensive approach taken towards number input output parameters process process parameters considered study tool rotational speed tool traverse speed tool tilt angle tool pin shape optimum design obtained reference output parameters including hardness grain size weld center zone maximum working temperature joint tensile strength elongation well vertical horizontal forces tool process analysis variance additionally performed evaluate significance design parameter output parameters results gained analysis variance indicated rotational speed traverse speed critical parameters determining weld mechanical properties well quality weld microstructure finally validate predicted optimum values based taguchi technique confirmation tests conducted excellent agreement observed predicted experimental values showing accuracy employed method obtained results
intestinal epithelium highly dynamic system continuously renewed process involving cell proliferation differentiation moreover main interface external environment maintenance regulation epithelial structure epithelial barrier function key determinants digestive health host well tight junction multiprotein complex composed transmembrane proteins associated cytoskeletal pen junctional ring actin myosin essential component barrier strictly regulated spatio temporal manner complex signaling network defects intestinal epithelial barrier function observed inflammatory bowel disease classic example connection inflammation cancer increased risk colorectal cancer patients inflammatory bowel disease recent years several molecules emerged critical players contributing inflammation associated colorectal cancer example eicosanoids derived arachidonic acid proposed mediators involved regulation epithelial structure function interestingly tissue concentration eicosanoids increases mucosal inflammation colorectal cancer development overview focuses physiological physiopathological roles eicosanoids cell growth cell differentiation apoptosis paracellular permeability intestinal epithelium better understanding processes foster new ideas development therapies chronic disorders elsevier inc rights reserved
aim although considerable efforts made improve relationships professionals parents suspected child maltreatment little research conducted examine ways parents escalate negative cognition behavior involving professionals study developed model parents negative reinforcement cognitive behavior factors influencing reductions reinforcement method interview data collected parents experienced outreach child protection issues analyzed using grounded theory approach result outreach phase analysis initially produced negative image help seeking behavior category followed dissatisfaction outreach reinforcement negative cognition categories phase analysis also identified social support support groups step means reducing negative cognition contrast child protection phase analysis produced anger psychological conflict child protection services unwilling consent categories phase analysis also identified psychoeducation timely feedback step acceptable means minimizing escalation negative cognition conclusion hypothetical model revealed ways parents changed cognition behavior demonstrated factors influencing reductions reinforcement negative cognition behavior results could useful practice child maltreatment cases authors published elsevier ltd
tumor cells induce immunosuppressive microenvironment leads towards tumor immune escape understanding intricacy immunomodulation tumor cells essential immunotherapy indoleamine dioxygenase ido immunosuppressive enzyme mediates tumor immune escape various cancers including hepatocellular carcinoma hcc ido regulation hcc may lead recruit ment regulatory cells tumor microenvironment therefore inhibit local immune responses promote metastasis hcc associated fibroblasts stimulate natural killer cells dysfunction prostaglandin subsequently ido promotes favorable condition tumor metastasis ido regulation induces immunosuppression may enhance risk hepatitis virus hepatitis virus induced hcc therefore ido inhibitors adjuvant therapeutic agents may clinical implications hcc review proposes future prospects ido therapeutic target also prognostic marker hcc
conversion lignocellulosic biomass electricity using fuel cell technologies promising challenging research topic sustainable electricity production lignocellulosic biomass generally directly used fuel electricity generation conventional fuel cell high efficiency typical fuel cells convert lignocellulosic biomass electricity mild conditions degrees include microbial fuel cells mfc novel direct biomass fuel cells dbfc mediated polyoxo metalates poms developed recently however efficiency power output low temperature fuel cells still need improved practical applications review focus research advances electricity generation fuel cells operated low temperatures specifically discussed progress challenge perspectives biomass fueled mfcs recent interesting researches dbfc also highlighted terms efficiency principles technological obstacles concluded work lignocellulosic biomass promising feedstock fuel cells renewable carbon neutral sustainable however power density lignocelluose fueled mfc usually far required commercial applications improving fermentable sugar release lignocellulosic biomass increasing cell output power main research points dbfc obtain high theoretical exergy recovery however still early stage development low efficiency research focused electrode development cell design parameter optimization process integration well understanding fundamental process mechanisms
paper describes framework software based networking smart factories enables easily adapt communication network changing requirements similar cloud based systems sfs could seen production clusters could rented configured needed network utilizes software defined networking sdn combined network functions virtualization nfv order achieve required flexibility paper presents discusses vision network architecture sfs based sdn network virtualization order support smart services especially industrie despite fact technology nowadays yet ready deployment today manufacturing networks present framework software defined factory networks discuss possible challenges benefits
background women termination pregnancy top higher rates chlamydia trachomatis general population study explored treatment prevention dutch top clinics comparison provided great britain methods qualitative study including semi structured interviews health care professionals hcps top clinics netherlands interviews recorded transcribed analysed thematic content analysis results prophylactic treatment azithromycin routinely prescribed surgical top medical top abortion pill sexually transmitted infections sti tests offered clients considered high risk sti uptake varies according health insurance coverage sti testing dutch clinics able provide free testing women years age sexual health counselling often limited discussing birth control major difference netherlands top clinics often offer free sti testing prophylaxis clients conclusion hcps dutch top clinics consider sti testing important part service financial barriers prevent testing location dutch top clinics offer sti tests women collaboration public health services could improve sti testing counselling young people furthermore clinics treat top clients prophylactic azithromycin could prevent upper genital tract post abortion infections
spatial skills fundamental engineers architects also professionals great variety fields skills crucial also academic training students ages academic year large scale study made university granada spain evaluate influence exerted skills several factors related personal aspects experience hobbies abilities beginning term spatial test questionnaire administered students three majors bachelor degrees civil engineering chemical engineering industrial electronic engineering studying courses graphic expression semester students invited participate set voluntary spatial skills training activities based exercises freehand sketching end term administered spatial test general intelligence problem solving ability gender construction games experience technical drawing factors directly related spatial skills furthermore training activities shown high degree effectiveness improving students spatial skills
patient specific beta tcp scaffold fabricated using indirect fabrication approach involves application rapid prototyping technology beta tcp powder concentrations analyzed different sintering temperatures scaffolds evaluated scanning electron microscopy ray diffraction compression tests fourier transform infrared spectroscopy cytotoxicity tests using human osteosarcoma cell line results include beta tcp scaffold porosity volumetric shrinkage mechanical properties bonding structural phase change cytotoxicity
neuropathic pain debilitating chronic pain condition occurring damage nervous system refractory currently available treatments major challenges include elucidating mechanisms developing new medications treat nerve injury induced pain hypersensitivity involves aberrant excitability spinal dorsal horn sdh neurons consequence dysfunction inhibitory interneurons hyperactivity glial cells especially microglia immune cells central nervous system evidence found using animal models investigate molecular cellular mechanisms neuropathic pain pathologically altered somatosensory signals sdh convey brain regions including anterior cingulate cortex acc regions nerve injury produces pre postsynaptic long term plasticity contributes negative emotions anxiety associated chronic pain conditions furthermore recent evidence also indicates descending projection pathways acc directly indirectly sdh top corticospinal network regulate nociceptive sensory transmission sdh thus understanding possible connection sdh acc including neuron microglia interaction may provide insights mechanisms used amplify pain signals related neuropathic pain clues aid development new therapeutic agents management chronic pain
study low voltage low power design previously introduced analog signal processing element called voltage differencing inverting buffered amplifier vdiba presented level shifter current mirrors used circuit design order accomplish low voltage low power operation configuration operates supply voltages consumes power bias current also low voltage transconductor highly linear executed use bulk driven quasi floating gate qfg source degeneration techniques simulations introduced circuit performed tsmc cmos technology spice theoretical approaches confirmed simulation results
behavioral health interventions move traditional digital platforms application evidence based theories techniques may doubly advantageous first expedite digital health intervention development improving efficacy increasing reach second moving behavioral health interventions digital platforms presents researchers novel potentially paradigm shifting opportunities advancing theories techniques particular potential technology revolutionize theory refinement made possible leveraging proliferation real time objective measurement big data commonly generated stored digital platforms much could done realize potential paper offers proposals better leveraging potential advantages digital health platforms reviews three cutting edge methods optimization designs dynamic systems modeling social network analysis
multiple assessment directed novelty search madns introduced authors extension novelty search algorithm exploits observation populations optimised phenotypic novelty may contain solutions multiple independent conflicting objectives shown application madns evolutionary trajectory may simultaneously directed towards multiple conflicting objectives previous results series simulated maze navigation experiments shown madns may significantly outperform novelty search domains potential phenotypic exploration high paper explore madns algorithm assessing effect upon diversity performance population phenotypic landscape increases series experiments domains multiple conflicting objectives expanding areas irrelevant space show relative performance gain madns increases alongside potential exploration conclude potential exploration within domain expands importance directing novelty becomes ever necessary
ministry health labour welfare issued notification regarding drugs influence driving afterward questionnaire survey drugs conducted involving health insurance pharmacies tokyo shiga prefectures result tokyo shiga pharmacies provided completed questionnaires notification sufficiently slightly recognized surveyed pharmacies respectively drugs driving related warning recognized pharmacies addition pharmacies reported always asked patients whether drive influence driving antianxiety drugs hypnotics antiepileptics smoking cessation drugs always explained patients pharmacies respectively concerning responses prescription drugs influencing driving proportion surveyed pharmacies tokyo shiga prefectures directed patients drive respectively directed patients stop driving developing symptom tokyo shiga prefectures showed significant difference reason prohibiting driving proportion pharmacies regarded strict medication adherence major importance treat patients primary diseases respectively difference might attributable high percentage patients driving pharmacies shiga prefecture facilitate prescription drugs influencing driving recommended design drug specific pharmaceutical education manuals also give consideration patients qol
recently demonstrated osteoblast specific overexpression human wnt increased cortical trabecular bone mass structure mice identify cell specific role wnt bone homeostasis created transgenic mice overexpressing human wnt osteocytes using dmp promoter dmp hwnt cbl background analyzed bone phenotypes serum bone biomarkers performed gene expression analysis measured dynamic bone histomorphometry dmp hwnt wild type mice compared mice dmp hwnt mice exhibited significantly higher whole body spine femoral abmd bmc trabecular cortical bone area thickness parameters male female weeks age femur stiffness ultimate force also significantly improved dmp hwnt female mice compared sex matched littermates addition female dmp hwnt mice displayed significantly higher mar bfr compared mice gene expression analysis demonstrated significantly higher mrna level alp male female dmp hwnt mice significantly higher levels osteocalcin opg rankl male dmp hwnt mice bone tissue compared sex matched mice results indicate wnt plays critical role acquisition cortical trabecular bone mass strength strategies designed use wnt target therapeutic interventions valuable treat osteoporosis low bone mass conditions
paper dimensional generalized shallow water wave equation investigated bilinear hirota method interestingly breather type lump type soliton solutions obtained furthermore dynamic properties soliton waves revealed means asymptotic analysis based hirota bilinear method riemann theta function succeed constructing quasi periodic wave solutions generalized form also display asymptotic properties quasi periodic wave solutions point relation quasi periodic wave solutions soliton solutions
colombian alzheimer prevention initiative api registry collaborative project among neurosciences group antioquia banner alzheimer institute genentech main goal provide source interested research participants data support api colombia autosomal dominant alzheimer disease trial help find treatments delay prevent clinical onset alzheimer disease
dynamic systems becoming steadily important profusion mobile distributed computing devices coincidentally incremental computation natural approach deal ongoing changes explore incremental computation parameterized complexity setting show incrementalization leads non trivial complexity classifications interestingly incremental versions hard problems become tractable others remain hard moreover tractability intractability simple function problem static complexity every level hierarchy exhibits complete problems tractable intractable incrementalizations problems already tractable static form also show incrementalization lead interesting algorithms improving upon trivial approach using static algorithm step
study used programmable system chip make fuel cell controller manage fuel cell operating environment proton exchange membrane fuel cell reacting performance closely related operating conditions temperature water management etc article investigates purge time interval control related characteristics controller developed study free additional power requirements using power provided fuel cell
number epidemiological studies established link alzheimer disease diabetes mellitus nuclear receptor peroxisome proliferator activated receptor gamma ppar gamma plays important role treatment however current ppar gamma targeting drugs thiazolidinediones tzds associated undesirable side effects identified herbal extract small molecular astragaloside selective ppar gamma natural agonist nervous cells developing ppar ppre pathway regulatory system cultured syy cells transfected pegfp bace treated plus ppar gamma antagonist vitro app mice intragastrically treated plus every months immunofluorescence western blotting real time pcr used examine expression ppar gamma bace immunohistochemical staining performed analyze distribution beta plaques app mouse brain levels beta determined using elisa kits shown ppar gamma agonist establishing high throughput screening model ppar gamma agonists results showed treatment increased activity ppar gamma inhibited bace vitro result beta levels decreased significantly ppar gamma antagonist significantly blocked beneficial role vivo treatment increased ppar gamma bace expression reduced neuritic plaque formation beta levels brains app mice effects could effectively inhibited results indicate may natural ppar gamma agonist suppressed activity bace ultimately attenuates generation beta therefore may promising agent modulating beta related pathology
paper presents novel multimodal system designed multi party human human interaction analysis design human machine interfaces multiple users challenging simultaneous processing actions reactions consistent proposed system consists large display equipped multiple sensing devices microphone array video cameras depth sensors multiple users positioned front panel freely interact using voice gesture looking displayed content without wearing particular devices motion capture sensors head mounted devices acoustic visual information captured processed jointly using established state art techniques obtain individual speech gaze direction furthermore new framework proposed model multimodal interaction verbal nonverbal communication events dynamics audio signals obtained speaker diarization head poses extracted video images modeled using hybrid dynamical systems hds show hds temporal structure characteristics used multimodal interaction level estimation useful feedback help improve multi party communication experience experimental results using synthetic real world datasets group communication poster presentations show feasibility proposed multimodal system
objectives pulmonary hypertension linked preterm birth explained congenital heart defects pulmonary diseases working hypothesis factors may influence risk among adolescences children born premature study design national registry based study assess risk following premature birth adjusted known risk factors patient subject selection methodology cases born identified diagnostic codes applicable retrieved swedish registry congenital heart disease six controls randomly selected matched case year birth hospital swedish medical birth register maternal infant data related preterm birth pulmonary diseases congenital defects retrieved association preterm birth pulmonary hypertension calculated conditional logistic regression taking account potential confounding factors results one third cases seven percent controls born preterm study preterm birth associated even adjusting confounding factors factors acute pulmonary diseases congenital heart defects congenital diaphragm herniation chromosomal disorders also associated multivariate analysis conclusions children young adults born preterm known increased risk previously explained congenital heart defects pulmonary diseases adjusting factors study indicates new factors may play role risk developing among children born preterm wiley periodicals inc
report synthesis two new artificial nucleobase scaffolds featuring adequate hydrogen bonding donors acceptors molecular recognition base pairs respectively tethering structures various amino acids assessment artificial nucleobaseamino acid conjugates rna ligands model hcv ires hid domain also reported compound displayed highest affinity twice lower neomycin control moreover appears interaction enthalpically entropically favored elsevier ltd rights reserved
imbalance generated power load demand major factor usually responsible frequency instability power systems especially islanded microgrids determine size loads shed appropriate locations power system maintain system frequency within permissible limits paper presents effective adaptive control scheme proposed controller stepwise load shedding approach designed islanded mgs regulate grid frequency providing amount power shortage achieve locally measures system parameters especially voltage frequency signals thereafter stepwise load shedding take place locations highest voltage drop frequency variation experienced load shedding step changes according certain factors shedding speed location value rate frequency change proposed approach eliminates adjustable loads return frequency back desired value simulation results proposed method different practical scenarios compared conventional pid controller provide considerable enhancement power system frequency stability elsevier rights reserved
improved route synthesis momelotinib developed nucleophilic addition reaction starting material morpholinoaniline cyanamide gave morpholinophenyl guanidine simultaneously methyl acetylbenzoate converted methyl dimethylamino acryloyl benzoate presence dimethylformamide dimethylacetal enaminone intermediate condensed elevated temperature alcoholic alkali morpholinophenyl guanidine form desired pyrimidine hydrolysed corresponding acid procedure simple operation without noble metal catalyst suitable industrial production finally desired compound momelotinib acquired amidation reaction
objective sunken temporal fossa appears oftentimes asians resembles bad fortune people wish change numerous techniques materials applied clinically augmenting sunken temporal fossa variable results microautologous fat transplantation maft technique proposed lin demonstrated favorable results facial rejuvenation present study authors applied maft technique innovative instrument sunken temporal fossa reported results methods microautologous fat transplantation performed patients year period starting january fat harvested liposuction processed refined centrifugation minutes purified fat microtransplanted temporal fossa assistance instrument maft gun patients followed regularly photographs taken comparison results average maft procedure took minutes complete average delivered fat right left side average follow period months complication including skin necrosis vascular compromise nodulation fibrosis asymmetry noted patient rated satisfaction point likert scale demonstrated patients favorable results satisfied satisfied conclusions concept technique maft along micro precise controlling instrument enabled surgeons perform fat grafting accurately consistently comparison strategies volume restoration maft procedure demonstrated patients high satisfaction long term results therefore potential maft alternative strategy sunken temporal fossa asians emphasized
simple test setup developed institute aerospace information technology university wurzburg germany realize basic functionalities formation flight quadrocopters test environment planned utilized developing validating algorithms formation flying capability real environment well education purpose already existing test bed single quadrocopter extended necessary inter communication distributed control mechanism test algorithms formation flights degrees freedom roll pitch study encompasses domain communication control engineering embedded systems programming bluetooth protocol used inter communication two quadrocopters simple approach pid control combination kalman filter exploited matlab instrument control toolbox used data display plotting analysis plots drawn real time received information also stored form files later use analysis test setup developed indigenously considerably low cost emphasis placed simplicity facilitate students learning process several lessons learnt course development setup proposed setup quite flexible modified per changing requirements
paper investigates relationship perceived ethnic age income diversity neighbourhood attachment accounting measures objective diversity calculated small individualised neighbourhoods data warsaw poland examine whether neighbourhood ties people different ethnicity age income moderate relationship perceived diversity attachment also test affective appraisals environment excitement irritation mediator perceived diversity attachment perceived ethnic diversity positively related neighbourhood attachment link mediated emotion excitement perceived income diversity undermined attachment regardless neighbourhood ties link mediated affective appraisals perceived age diversity related lower neighbourhood attachment individuals ties neighbours different ages argue effects diversity may depend socio cultural context specifically level meaning diversity given society
letter proposes novel framework classification light detection ranging lidar derived features context several features extracted directly lidar point cloud data using aggregated local point neighborhoods including laser echo ratio variance point elevation plane fitting residuals echo intensity additionally lidar digital surface model dsm input classification thus lidar raster dsm also rich geometric also backscatter point cloud information aggregated images considered workflow extracted features characterized base images fed extinction profiles model spatial contextual information composite kernel support vector machine investigated efficiently integrate elevation spatial information suitable lidar data results indicate proposed method obtain high classification accuracy using lidar data alone overall accuracy benchmark houston lidar data using standard set training test samples classes short cpu processing time
equivalent electrical circuits including parasitic elements variations injected bias current three semiconductor optical amplifiers soa obtained frequency domain measurements tuning numerical modeling parameters used extract circuit parameters characterization chip carrier encapsulated devices agree numerical data ghz results relevant designing fast speed soa gated switches optical routers elsevier rights reserved
background skin skin contact mother infant commonly referred kangaroo care demonstrated efficacy pain relieving strategy infants yet remains underutilized clinical practice purpose evaluate changes neonatal intensive care unit staff nurse beliefs utilization challenges related practice change implementing intervention management procedural pain preterm infants time points methods nurses participated larger clinical trial examining sustained efficacy asked complete questionnaire time points month following study initiation identified benefits expectations frequency use challenges related practice change uptake described using frequencies percentages data different time points compared using analysis results nurses approached completed questionnaire month month time point sample participants indicated expected provide good pain relief better staff nurses reported significantly improved preconceived ideas chi significantly fewer concerns chi related using pain relieving intervention time points significant differences seen frequency using intervention time points implications research practice despite increasingly positive preconceived ideas reduced concerns frequency using procedural pain relief remained unchanged research addressing ways overcome barriers utilizing intervention procedural pain warranted
diseases conditions diverse etiology hemoglobinopathies hereditary hemochromatosis menopause could lead chronic iron accumulation condition frequently associated bone phenotype characterized low bone mass osteoporosis osteopenia altered microarchitecture biomechanics increased incidence fractures osteoporotic bone phenotype constitutes major complication patients iron overload purpose review summarize learnt iron overload associated bone loss clinical studies animal models bone metabolically active tissue undergoes continuous remodeling involvement osteoclasts resorb mineralized bone osteoblasts form new bone growing evidence suggests increased bone resorption decreased bone formation involved pathological bone loss iron overload conditions discuss cellular molecular mechanisms involved detrimental process fuller understanding complex mechanism may lead development improved therapeutics meant interrupt pathologic effects excess iron bone
work investigate influence nicotine exerts attention focusing modeling coupling reward thalamocortical circuits neuron neural networks replicate circuits described carefully designed coupled system nonlinear differential equations details essential neurophysiological properties computer simulations reward attention circuit reflects spiking behavior individual neuron network presence absence nicotine becomes clear changes dopaminergic levels reward circuit due nicotine strongly influences nigral dopaminergic activity modulates thalamocortical filtering mechanism results indicate nicotine strengthens attentional focus particular stimulus decreasing smoker mental flexibility also simulations highlight aspects clinical inattention symptoms particularly attention deficit hyperactivity disorder show patients suffering attentional lability might improve attentional focus exposed nicotine elsevier rights reserved
recent variants distributed denial service ddos attacks leverage flexibility application layer protocols disguise malicious activities normal traffic patterns concurrently overwhelming target destination large request rate new countermeasures necessary aimed guaranteeing early reliable identification compromised network nodes botnet work introduce formal model aforementioned class attacks devise inference algorithm estimates botnet hidden network converging true solution time progresses notably analysis validated real network traces
introduction objectives purpose study use high accurate mass metabolomic profiling investigate differences within phenotypically diverse canine population breed related morphological physiological behavioural differences previously using broad metabolite fingerprinting approach lipids appear dominate inter intra breed discrimination purpose use ultra high performance liquid chromatography high resolution mass spectrometry uhplc hrms identify detail inter breed signatures plasma lipidomic profiles home based client owned dogs maintained different diets fed according owners feeding regimens methods nine dog breeds recruited study beagle chihuahua cocker spaniel dachshund golden retriever greyhound german shepherd labrador retriever maltese dogs per breed metabolite profiling mtbe lipid extract fasted plasma performed using uhplc hrms results multivariate modelling classification indicated main source lipidome variance three breeds chihuahua dachshund greyhound six breeds however intrabreed variance evident labrador retrievers metabolites associated dietary intake impacted breed associated variance following filtering signals data set unique inter breed lipidome differences chihuahua golden retriever greyhound identified conclusion using phenotypically diverse home based canine population able show high accurate mass lipidomics enable identification metabolites first pass plasma profile capturing distinct metabolomic variability associated genetic differences despite environmental dietary variability
africa around mortalities per annum hiv aids related deaths due affects cryptococcal meningitis fungal infection recently world health organisation infectious disease society america idsa recommended first line treatment combination amphotericin flucytosine essential medicines however flucytosine even registered use african nation due part relatively high cost manufacture lack generic manufacturers currently flucytosine manufactured expensive four step manufacturing process report one step continuous flow process involving reaction inexpensive cytosine fluorine gas using stainless steel tubular laboratory pilot scale silicon carbide reactor devices readily scaleable manufacturing process low initial capital expenditure
context lystedt law requires high school athletes sustained concussion removed practice play allowed return cleared medical professional objective determine effect lystedt law injury concussion documentation seattle public high schools design cross sectional study setting seattle public high schools patients participants numbers students aged years school years respectively main outcome measure injuries documented sportsware athletic trainers seattle public high schools evaluated injuries including concussions recorded school year lystedt law school years law took effect incidence rates law estimated compared results concussion rate comparison relative risks showed incidence rates concussions different year lystedt law relative risk confidence interval years law relative risk overall mean number days play almost days greater law took effect difference days females mean number days play days difference days days difference days conclusions number documented concussions doubled institution lystedt law may attributed heightened awareness closer monitoring
aim neuropeptide calcitonin gene related peptide cgrp found afferent sensory nerve fibers innervating resistance arteries plays pivotal role number neurovascular diseases migraine subarachnoid bleedings present study investigates binding antagonistic characteristics small non peptide cgrp receptor antagonists gepants isolated rat brain mesenteric resistance arteries methods antagonistic behavior gepants investigated isolated rat mesenteric arteries using wire myograph setup binding gepants cgrp receptors investigated rat brain membranes using radioligand competitive binding assay furthermore histological location key components cgrp receptor ramp clr assessed immunohistochemistry results functional studies clearly show gepants reversible competitive antagonists producing schild plot slopes significantly different unity thus suggesting presence uniform cgrp receptor population arteries uniform receptor population also confirmed radioligand competitive binding studies showing similar affinities gepants rat brain mesenteric arteries exception rimegepant fold lower affinity brain mesenteric arteries clr ramp shown located vascular smooth muscle endothelial cells rat mesenteric arteries immunohistochemistry conclusion present results indicate despite species differences cgrp receptor affinity antagonistic nature gepants distribution pattern cgrp receptor components mechanism behind cgrp induced vasodilation seem similar resistance sized arteries human rats elsevier inc rights reserved
addictions including alcohol use disorders characterized loss control drug seeking consumption neural circuits signaling mechanisms responsible transition controlled use uncontrolled abuse remain incompletely understood prior studies shown compulsive like behaviors rodents example persistent responding ethanol etoh despite punishment increased chronic exposure etoh main goal current study assess effects chronic intermittent etoh cie exposure multiple putative measures compulsive like etoh seeking cbl mice mice exposed two four weekly cycles cie post withdrawal tested progressive ratio responding etoh sustained responding signaled etoh unavailability footshock punished suppression responding etoh results showed mice exposed cie exhibited attenuated suppression etoh seeking punishment compared air exposed controls contrast cie exposure affected neither punished food reward seeking behavior putative measures compulsive like etoh seeking vivo reverse transcription polymerase chain reaction analysis brain tissue found reduced sensitivity punished etoh seeking cie exposure accompanied significant increase gene expression glun gluna subunits methyl aspartate receptor specifically medial orbitofrontal cortex moreover slice electrophysiological analysis revealed increased methyl aspartate receptor mediated currents orbitofrontal cortex cie exposure test naive mice collectively current findings add growing body evidence demonstrating chronic exposure etoh fosters resistance punished etoh seeking association adaptations cortical glutamatergic transmission
elimination cells producing autoantibodies neuroantigens considered beneficial treatment multiple sclerosis myelin oligodendrocyte glycoprotein mog significant autoantigen multiple sclerosis shown mog like peptoid amogp bind autoantibodies produced pathological lymphocytes propose structure innovative drug targeted elimination pool autoreactive cells responsible multiple sclerosis pathogenesis compound complex peptoid amogp fragment human immunoglobulin obtained peg amogp conjugate effectively interact autoreactive antibodies attests high therapeutic potential
heavily duty cycled embedded systems energy consumed microcontroller idle mode often bottleneck battery lifetime existing solutions address problem placing microcontroller low power sleep mode idle preserving application state either retaining data situ static random access memory sram checkpointing flash however approaches notable drawbacks situ data retention requires sram remain powered sleep mode checkpointing flash involves significant energy time overheads article proposes new ultra low power sleep mode microcontrollers overcomes limitations approaches technique hypnos based key observation chip sram microcontroller exhibits data retention even much lower supply voltage much lower typical operating voltage microcontroller hypnos exploits observation performing extreme voltage scaling microcontroller sleep mode implement evaluate hypnos mspg microcontroller show microcontroller mcu draws proposed sleep mode lower baseline sleep mode preserves sram contents reduce overheads associated performing voltage scaling propose use energy harvesting source providing scaled supply voltage demonstrate using light sensing photodiode current consumption proposed sleep mode reduced lower current consumption baseline low power mode also show decrease sleep mode power consumption translates reduction application level energy consumption much decreasing average power consumption minuscule levels hypnos takes significant step forward making perpetual systems reality use energy harvesting
background ticks attach penetrate hosts skin inactivate multiple components host responses order acquire blood meal infestation loads cattle tick rhipicephalus microplus heritable breeds carry high loads reproductively successful ticks whereas others ticks feed reproduce efficiently methods order elucidate mechanisms result different outcomes infestations cattle ticks examined global gene expression inflammation induced tick bites skins one resistant one susceptible breed cattle underwent primary infestations larvae nymphs microplus also examined expression profiles genes encoding secreted tick proteins mediate parasitism larvae nymphs feeding breeds results functional analyses differentially expressed genes skin suggest allergic contact like dermatitis develops ensuing production cxcl ccl sustained hmgb isg pkr leading expression pro inflammatory chemokines cytokines recruit granulocytes lymphocytes importantly response delayed susceptible hosts histopathological analyses infested skins showed inflammatory reactions surrounding tick cement cones enable attachment breeds genetically tick resistant bovines destabilized cone transcription data provided insights tick mediated activation basophils previously shown key host resistance model systems skin tick susceptible bovines expressed transcripts encoding enzymes detoxify tissues interestingly enzymes also produce volatile odoriferous compounds accordingly skin rubbings tick susceptible bovines attracted significantly tick larvae rubbings resistant hosts moreover transcripts encoding secreted modulatory molecules tick significantly abundant larval nymphal salivary glands ticks feeding susceptible bovines conclusions compared tick susceptible hosts genes encoding enzymes producing volatile compounds exhibit significantly lower expression resistant hosts may render less attractive larvae resistant hosts expose ticks earlier inflammatory response ticks associated significantly lower expression genes encoding salivary proteins suppress host immunity inflammation coagulation
surgical site infection ssi common complication following surgical procedures study aimed determine risk factors associated ssi patients crohn disease complicated gastrointestinal fistula retrospective review patients underwent surgical resection gastrointestinal fistula patients january january identified prospectively maintained gastrointestinal fistula database demographic information preoperative medication intraoperative findings postoperative outcome data collected univariate multivariate analysis carried assess possible risk factors ssi total patients identified men average age patients years average body mass index bmi rate ssi multivariate analysis preoperative anemia preoperative bacteria present fistula tract preoperative enteral nutrition months predictors ssi notably preoperative percutaneous abscess drainage shown exert protection ssi fistulizing preoperative anemia bacteria present fistula tract preoperative months significantly increased risk postoperative ssi gastrointestinal fistula complicated preoperative identification risk factors may assist risk assessment optimize preoperative preparation perioperative care
simplified method predicting deflections cable stayed suspension bridges considering live loads presented proposed method governing equation cable stayed suspension bridge based potential energy method derived fourier series used describe defections bridge deck shown numerical investigation two different cable stayed suspension bridges iteration procedure high convergence rate iterations needed small number series terms sufficient achieving solutions problems predictions proposed method show good agreement finite element results
managing context dependent behavior devices constantly move laborious task especially comes situations users therefore devices unfamiliar due impossibility using predefined rules previous training static machine learning context awareness methods impractical although collaboration nearby peers represents promising alternative research area scarce paper propose distributed consensus protocol specifically designed enable device cooperation adaptation purposes protocol designed implemented performance demonstrated simulation
passive design widely identified one economical effective strategies sustainable building use animate building space one significant passive strategy architectural design two properties organic dynamic type includes atriums courtyards wind towers light wells patios sunspaces etc study introduces logical scientific method assessing building space performance multi criteria approach developed validate optimize influence animate spaces sustainable buildings emphasis influence building environment quality occupant satisfaction considering relationship building people building environment focusing primarily building design building environment control research introduces evaluation tool called sctool sctool includes compasses measure occupant satisfaction indoor physical environment performance satisfaction comfort matrix evaluates fluctuating performances animate spaces building overall sustainable performance building operating phase research chose atrium represent one typical animate spaces adopted pair group analysis method isolate analyze single variable four typical atriums chosen divided two categories direction atriums high rise building atriums test group buildings included one green building one conventional building results indicate level environmental performance object building highlight optimized possibilities atrium entire building design renovation phases elsevier ltd rights reserved
long island sound watersheds lisw experiencing significant land use cover change lucc affects environment ecosystems watersheds water pollution carbon emissions loss wildlife lucc modeling important approach understanding happened landscape may change future moreover prospective modeling provide sustainable efficient decision support land planning environmental management paper modeled luccs lisw new england region experienced increase developed area decrease forest low density development pattern played important role loss forest expansion urban areas key driving forces distance developed areas distance roads social economic drivers nighttime light intensity population density addition paper compared evaluated two integrated lucc models logistic regression markov chain model multi layer perception markov chain mlp model models achieved high accuracy prediction mlp model performed slightly better finally land use map predicted using mlp model indicates continued loss forest increase developed area
dermatologic diseases traditional risk factors stroke recent studies show atopic dermatitis psoriasis bullous skin disease may increase risk stroke cardiovascular diseases previous studies focused association contact dermatitis stroke established cohort comprised contact dermatitis patients newly diagnosed randomly selected subjects without disorder frequency matched sex age diagnosis year comparison cohort none history stroke stroke incidence assessed end cohorts incidence stroke fold higher contact dermatitis cohort comparison cohort per person years multivariable cox method analyzed adjusted hazard ratios ahrs confidence interval stroke types ischemic stroke hemorrhagic stroke age specific ahr stroke contact dermatitis cohort increased age years years older ahr stroke men women respectively study suggests patients contact dermatitis modestly increased risk stroke significant ischemic stroke hemorrhagic stroke comorbidity particularly hypertension increased hazard stroke
rationale adaptive multiple features method amfm lung texture analysis software recognizes high resolution computed tomography hrct patterns objectives evaluate amfm visual quantification hrct patterns relationship disease progression idiopathic pulmonary fibrosis methods patients idiopathic pulmonary fibrosis clinical trial prednisone azathioprine acetylcysteine underwent hrct study start finish proportion lung occupied ground glass ground glass reticular ggr honeycombing emphysema normal lung densities measured amfm three radiologists documenting baseline disease extent postbaseline change disease progression includes composite mortality hospitalization fvc decline measurements main results agreement visual amfm measurements moderate ggr pearson correlation mean difference limits agreement baseline extent ggr independently associated disease progression adjusting baseline gender age physiology stage smoking status hazard ratio per visual ggr increase confidence interval hazard ratio per amfm ggr increase postbaseline visual amfm ggr trajectories correlated postbaseline fvc trajectory respectively conclusions extensive baseline visual amfm fibrosis measured ggr densities independently associated elevated hazard disease progression postbaseline change amfm measured visually measured ggr densities modestly correlated change fvc amfm measured fibrosis automated adjunct existing prognostic markers may allow study enrichment subjects increased disease progression risk
background reduction estimated glomerular filtration rate egfr presence proteinuria predominant manifestations chronic kidney disease ckd common elderly population objective article outlines clinical significance ckd elderly summarises recently updated recommendations assessment staging management discussion elderly patients ckd present asymptomatically despite clinically significant one potent risk factors cardiovascular disease even modest reductions egfr associated increased prevalence ckd related complications anaemia hyperphosphataemia early detection important strategy include three components kidney health check blood pressure measurement blood test serum creatinine egfr urine test albumin creatinine ratio treatment guided patient stage ckd based kidney function egfr kidney damage degree albuminuria control blood pressure recommended levels appropriate medications majority elderly patients ckd ultimately require desire renal replacement therapy may safely managed general practice
activated peroxisome proliferator activated receptor delta ppar delta induces expression genes encoding enzymes metabolize fatty acids carbohydrate attempts identify cellular activators ppar delta produced large lists various fatty acids metabolic derivatives however consensus specific selective binding interactions natural ligands ppar delta models binding interactions within ligand binding domain lbd ppar delta derived analyses ppar delta lbd crystals formed synthetic low molecular weight ligands nonetheless crystals whole receptor natural ligands heterodimer cognate retinoid receptor rxr yet available analysis found hydroxyalkenals non enzymatic peroxidation products polyunsaturated fatty acids pufa namely hydroxy dodecadienal hdde hydroxy nonenal hne activate ppar delta vascular endothelial cells insulin secreting beta cells respectively cases activated ppar delta induced adaptive responses allowed cells adjust ambient stressful metabolic conditions review article addresses interactions hydroxyalkenals ppar delta resulting hormetic interactions cells exposed nutrient overload conditions elsevier societe francaise biochimie biologie moleculaire sfbbm rights reserved
aimsto investigate local regulatory role mucosa bladder strip contractility normal overactive bladders examine effect botulinum toxin bont methodsbladder strips spontaneously hyperactive rat shr normal rats sprague dawley dissected myography intact mucosa free preparations spontaneous neurogenic agonist evoked contractions investigated shr strips incubated bont assess effects contractility resultsspontaneous contraction amplitude force integral frequency significantly different shr mucosa free strips compared intacts contrast spontaneous contraction amplitude force integral smaller mucosa free strips intacts frequency affected mucosa frequency spontaneous contractions shr strips significantly greater strips neurogenic contractions mucosa free shr strips higher frequencies smaller intact strips mucosa affect carbachol evoked contractions intact versus mucosa free strips shr bladders bont reduced spontaneous contractions shr intact strips trend also observed mucosa free strips significant neurogenic carbachol evoked contractions reduced bont mucosa free intact strips depolarisation induced contractions smaller bont treated mucosa free strips conclusionsthe mucosal layer positively modulates spontaneous contractions strips normal overactive shr bladder strips novel finding bont reduction contractions shr mucosa free strips indicates actions detrusor independent classical action neuronal snare complexes
paper describes experience held class primary school children aimed introduce novel educational topic smart materials interfaces built smart material interfaces pupils guided along multidisciplinary path traditional innovative teaching methods composed educating engaging children led creation automated puppet plays focused themes environmental awareness result process storytelling visual programming acted powerful means merging different educational concepts techniques data collected direct observation questionnaires indicate experience perceived positive interesting post evaluation held months later revealed skills knowledge improvements areas involved multidisciplinary experience elsevier ltd rights reserved
renewed attention paid quality qualitative research studies development impact wake intense debate role randomised control trials debates raised bar quality also provoking concerns whose voices matter politics evidence based policymaking article argues issues addressed guba lincoln trustworthiness criteria particularly principle authenticity developed respond demands research transformative emancipatory adopting criteria commissioned evaluations checklist artefacts means improve rigour raise ethical standards
tight integration cyber dominated control systems physical systems helped electric vehicles cyber physical system cps achieve zero emission transportation capability however poses major difficulties poor driving range high price troublesome recharging demotivate consumers problems arisen due stringent constraints battery packs moreover battery capacity degrades overtime degradation defines battery lifetime shortens driving range driving range battery lifetime mainly influenced route behavior electric motor heating ventilation air conditioning hvac power consumption paper present novel jointly optimized eco friendly automotive climate control navigation system methodology integration two systems helps optimize hvac utilization route better battery lifetime driving range compared performance methodology state arts different weather route behavior seen upto improvement battery lifetime reduction energy consumption
electrical circuits difficult understand novices tend inadequate understandings happens level atoms electrons leading difficulty predicting outcomes electrical circuits level wires resistors light bulbs paper argue integrating micro macro representations electrical circuit provide students better understanding fundamental concepts electricity introduce spark interactive multi level simulation environment enables learners interact representations electrical circuit levels primary goal design familiarize students electrical current resistance potential difference circuit conducted study university students shows ability design improve novice understanding electrical circuits study offers evidence learners able develop better understandings fundamental concepts electricity drawing micro level macro level representations electrical circuit
number methods developed years control training volumes optimize player performance prevention injuries become priority coaching staffs authors consider training volume intensity frequency key prevention sports injuries goal study assess effectiveness variety preventive measures focused volume intensity frequency included training program professional futsal team number injuries sustained compared team season sample included futsal players results obtained show reducing monthly total training volume lowering number high intensity microcycles decreasing number weekly training sessions effective reducing injury occurrence one season compared season
construction project managers often face problems trying change work practices management research addresses problems offering stylized abstract models unfortunately may say little actual work practices managers want change practice theory offers alternative way address practice related managerial problems arguing learning central enabler performing practices early research practice based learning construction management exists understanding theory applied lacking address limitation systematic literature review published construction management articles conducted articles divided five practice related analytical categories participation context meaning production power becoming practitioner identify areas theory discussed participation context discussed published articles meaning production power becoming practitioner might suggest latter categories offer possibilities future research articles analysed lakatosian research programme lens showing progressive research programme exists practice based studies construction management findings provide avenues future construction management studies seeking apply practice based learning theory understand learning construction projects better
selection suitable working fluids use organic rankine cycles orc strongly addicted intended application orc system design orc kind heat source ambient condition influence performance organic rankine cycle selection working fluid come discrepancy best candidate thermodynamic point view transformation real machine design axial turbine design considered expansion energy conversion within orc vapor volume flow ratios within expansion path pressure ratio course number stages considered within fluid selection process design parameters furthermore environmental aspects taken account global warming potential gwp flammability selected fluid paper shows results design fluid selection process organic rankine cycle application combined operation class industrial gas turbine gas turbine contains two radial compressor stages integrated intercooler increase thermal cycle efficiency recuperator implemented gas turbine cycle uses exhaust gas waste heat preheat compressed air second compressor enters combustion chamber shaft power generated three stage axial turbine whereby first stage convection cooled stage due turbine inlet temperature degrees increase electrical efficiency power output energy conversion cycle combined operation organic rankine cycle intended therefore waste heat compressor intercooler used first heat source waste heat exhaust gas recuperator second heat source organic rankine cycle intended orc fluid acts heat absorption fluid within compressor intercooler due specifications orc detailed thermodynamic analysis performed determine optimal design parameter best working fluid orc order obtain maximum power output combined cycle due twice coupling orc cycle heat exchange two cycles bounded detailed analysis coupled cycles necessary ambient temperature enormous influence transferred heat intercooler orc cycle affects heat transfer temperatures transferable heat second heat source thus detailed analysis considering ambient operation conditions performed order provide efficient energy conversion system wide operation range performance analysis shown application orc combined operation intercooled recuperated gas turbine combined cycle efficiency increased wide ambient conditions range pts electrical power output comparison stand alone intercooled recuperated gas turbine
olympic games constitutes world largest sporting event nurses play important poorly discussed role emergency care routine clinical care preventive care athletes many cultures well enormous influx spectators article discuss five important considerations preparing nurses provide safe care olympians elite athletes cultural group caring olympic family disaster preparedness security infection control principles transcultural nursing nature sports types injuries effects climate challenges differ somewhat summer winter olympics nevertheless olympic games provide tremendous opportunity experience transcultural nursing highlight nurses play significant role care athletes olympic family spectators
volume classical electrical machines occupied magnetic materials creating good possible magnetic path machines planar flux paths geometries material laminated reduce eddy current losses core manufacturers typically supply reference values epstein frame measurements material performance specification easy way comparison however magnetic flux path electrical machines complex due rotating magnetic fields passing stator without teeth rotor airgap therefore material characterization methods ring core measurements suitable characterize magnetic materials electrical machines paper gives short introduction different methods characterize magnetic materials detailed description building measurement system characterizing ring core samples electrical machine stator cores system developed regard iec standard measurements magnetic ring core samples easily build lab power amplifier standard industrial control system equipped analog input output interfaces finally reference measurements demonstrate performance system
magnesium essential chemical element organisms intervening cellular enzymatic reactions thus importance homeostasis therapeutic tool highly challenging patients pediatrics primary purpose paper review role magnesium sulfate adjuvant drug pediatric anesthesia compound already scientific backing certain aspects analgesia muscle relaxation theoretical empirical backing others organ protection inflammation seems promising multitude potential applications pediatric anesthesia high safety low cost make magnesium sulfate could considered super adjuvant
power critical resource organizational actors given profound importance power individual functioning essential understand individuals acquire power others individuals retain power attained others fall lofty positions spite political advantages power provides review conceptualize power process unfolds time review research speaks three distinct related dynamics acquisition maintenance loss power address attempt reconcile burgeoning set findings appear conflict especially findings vis vis maintenance loss power conclude addressing overlooked topics areas future research
background patients negative myeloproliferative neoplasms mpn polycythemia vera essential thrombocythemia primary myelofibrosis pmf increased risk thrombosis thromboembolism major bleeding due morbidity mortality events antiplatelet anticoagulant agents commonly employed primary secondary prophylaxis hand disease related bleeding complications esophageal varices common patients mpn analysis performed define frequency events identify risk factors assess antiplatelet anticoagulant therapy cohort patients mpn methods mpn registry study alliance leukemia non interventional prospective study including adult patients mpn according criteria statistical analysis descriptive methods tests significant differences well contingency tables used identify odds potential risk factors vascular events results mpn subgroups significantly differed sex distribution age diagnosis blood counts ldh levels jakvf positivity spleen size length thromboembolic events occurred around time mpn diagnosis one third events occurred date splanchnic vein thrombosis frequent post mpn patients chance developing thromboembolic event significantly elevated patients suffered post splenomegaly significant odds major bleeding previous thromboembolic events splenomegaly administration heparin major bleeding episodes significantly less frequent patients compared mpn subgroups conclusions together report unselected real world cohort german mpn patients reveals important data prevalence diagnosis treatment thromboembolic major bleeding complications mpn
objectives study examine prevalence diabetes hypertension among church personnel north eastern democratic republic congo identify socio demographic factors health behaviors associated outcomes data study obtained sample pastors wives church workers north eastern congo pearson chi square binary logistic regression analyses conducted diabetes status hypertension outcome variables little one ten respondents diabetic respondents diabetes approximately two thirds aged respondents aged found hypertensive adjusting predictors respondents older market women homemakers used vehicles opposed walking biking means transport likely diabetic also respondents older overweight likely hypertension paper discusses results implication public health policy diabetes prevention particularly among older individuals religious workers africa
nowadays seen increasing use microprocessors electric motor monitoring systems systems often used measure basic operating parameters electric motors like current voltage active reactive power existing measuring methods require relatively high sampling rate signals measurement relatively high computational power processing acquired data paper presents new measuring method calculating procedures achieve parameters motor mentioned method consists parallel sampling current voltage signals low sampling rate calculation formulas used method relatively simple allows application simple cheap microprocessor systems paper presents theoretical basis measuring method processing algorithms block diagram microprocessor measuring system microcontroller atmega calculation algorithm method presented laboratory tests low power electric motor performed results achieved new method compared classical one
polished finishing granites greatly accepted claddings plates shape design color variety features depend geological conditions occur formation process include mineralogy stone fluids formed process grain size minerals way minerals interact one noblest uses stone plates non adherent covering systems without mortar ventilated double dagger ades pedestrian paving systems currently methodology non adherent systems uses allowable stress design criteria recent years number papers indicating reliability analysis important design tool natural stones increased however lack information concerning design methodology still happens therefore structural properties assessed complementing studies compressive strength three point flexural tensile strength young modulus poisson ratio granite slab design example also presented first thickness plates determined based formulation proposed timoshenko strength materials original language portuguese volume editora livro cnico rio janeiro using allowable stress design criteria next reliability analysis performed monte carlo simulation results showed desire white granitic plate presented higher reliability index capo bonito red granitic plate result seems paradoxical owing capo bonito red presented higher value mean flexural strength desire white minimal safety factors satisfy target reliability value recommended standard eurocode found respectively three stone types
paper deals methods programming digital signal processors based long instruction word vliw architecture compares used methods using common algorithm signal processing domain comparison shows advantages disadvantages methods paper also introduces new method programming vliw processors method could describe digital signal processing algorithm signal flow graph instead sequential definition result system generated low level source code semi optimal stage
paper deals cancer invasion model delta chi del center dot del del center dot del element omega delta element omega eta element omega bounded smooth domain omega subset zero flux boundary conditions chi eta positive parameters compared previous mathematical studies novelty lies first treatment full parabolic chemotaxis haptotaxis system second allowing positive values eta reflecting processes self remodeling extracellular matrix appropriate regularity assumptions initial data using adapted estimate techniques prove global existence uniqueness classical solutions sufficiently large high cell proliferation rate regime elsevier inc rights reserved
background compulsive sexual behaviors csb relatively common associated significant personal social dysfunction underlying neurobiology still poorly understood present study examines brain volumes resting state functional connectivity csb compared matched healthy volunteers methods structural mri mprage data collected subjects csb males age matched male analyzed using voxel based morphometry resting state functional mri data using multi echo planar sequence independent components analysis ica collected subjects csb subjects age matched results csb subjects showed greater left amygdala gray matter volumes small volume corrected bonferroni adjusted reduced resting state functional connectivity left amygdala seed bilateral dorsolateral prefrontal cortex whole brain cluster corrected fwe compared conclusions csb associated elevated volumes limbic regions relevant motivational salience emotion processing impaired functional connectivity prefrontal control regulatory limbic regions future studies aim assess longitudinal measures investigate whether findings risk factors predate onset behaviors consequences behaviors authors human brain mapping published wiley periodicals inc
novel learning algorithm single hidden layer feedforward neural network extreme learning machine attracted much research attention fast training speed good generalization performances instead iteratively tuning parameters extreme machine seen linear optimization problem randomly generating input weights hidden biases however random determination input weights hidden biases may bring non optimal parameters negative impact final results need hidden nodes neural network overcome drawbacks caused non optimal input weights hidden biases propose new hybrid learning algorithm named dolphin swarm algorithm extreme learning machine adopting dolphin swarm algorithm optimize input weights hidden biases efficiently set input weights hidden biases encoded one vector namely dolphin dolphins evaluated root mean squared error updated four pivotal phases dolphin swarm algorithm eventually obtain optimal set input weights hidden biases evaluate effectiveness method compare proposed algorithm standard extreme learning machine three state art methods particle swarm optimization extreme learning machine evolutionary extreme learning machine self adaptive evolutionary extreme learning machine benchmark datasets obtained university california irvine machine learning repository experimental results demonstrate proposed method achieve superior generalization performances compared algorithms
good parametrizations affine transformations essential interpolation deformation analysis shape motion animation one central research topics computer graphics however single perfect method one advantages disadvantages paper propose novel parametrization affine transformations generalization improvement existing methods method adds yet another choice existing toolbox shows better performance applications implementation available make framework ready use various applications
purpose rathke cleft cysts rcc usually asymptomatic observed via use conservative methods patients rccs however severe headaches even small enough confined sella small rccs seldom discussed study presents investigation clinical characteristics small rccs associated severe headaches demonstrating efficacy safety endoscopic transsphenoidal surgery etss relieve headaches methods study patients small rccs maximum diameter presented headaches treated etss institute recruited rccs treated headache impact test hit score calculated pre postoperatively evaluate headache severity results patients complained severe headaches disturbed daily life headaches nonpulsating localized frontal area characteristically patients experienced severe headaches sudden onset continued chronically hit score average meaning headaches affected daily life severely surgical decompression cyst headache patients improved dramatically hit score decreased significantly suggesting headaches diminished newly developed deficiencies anterior pituitary lobe function detected postoperative occurrence diabetes insipidus found patients transient recurring cysts found conclusions severe headaches develop small rccs present study etss performed patients effectively safely relieve headaches
present work shows teaching learning experience developed department manufacturing engineering university malaga experience based need generate specific glossary manufacturing engineering terms used study guide students eventually decided make thesaurus would aimed teaching activity addition would take part educational innovation project pie university malaga within biennium first step consisted design thesaurus pattern taking account kind information necessary include afterward pattern would place virtual campus student would complete information required finally results obtained different applications activity would analyzed evaluated published elsevier ltd
paper proposes splittable amplifier technique either decomposed two identical halves merged enhancing utilization amplifier power alleviating memory effect applying operational amplifier opamp sharing two phase clock system amplifier split two identical small amplifiers one phase simultaneously use two circuits next two small amplifiers merged one amplifier phase usage another circuit compared conventional opamp sharing power efficient amplifier arrangement achieved split mode paper three individual sample hold circuits proposed technique designed demonstrate efficiency memory effect cancellation simulations show contrast output spectrum two circuits conventional opamp sharing spurious tones due memory effect suppressed least split mode least combination mode input signal using proposed technique
research underwater image segmentation deal rapid increasing volume images videos handle issue parallel computing paradigms mapreduce framework proven viable solution therefore propose mapreduce based fast fuzzy means algorithm mrffcm paralyze segmentation images work use two layer distribution model group large scale images adopt iterative mapreduce process parallelize ffcm algorithm combinational segmentation way used improve algorithm efficiency evaluate performance algorithm develop small hadoop cluster test mrffcm algorithm experiment results demonstrate proposed method effective efficient large scale images compared traditional non parallel methods algorithm expected provide efficient segmentation images least improvement meanwhile growth cluster size improvement algorithm performance also achieved consequently scalability enable proposed method used effectively oceanic research underwater data processing systems elsevier rights reserved
encountered patient infantile nephrotic syndrome associated dense interstitial inflammatory infiltrate prominent extramedullary hematopoiesis immunohistochemical analysis revealed numerous terminal deoxynucleotidyl transferase tdt positive cells may raise concern lymphoblastic lymphoma thus characterized group pediatric kidneys inflammation tdt positive nuclei quantitated dual immunostains tdt cda tdt tdt performed subset cases flow cytometry performed case tdt positive nuclei present inflamed pediatric kidneys patients tdt counts average maximal high power fields ranged mean presence number tdt positive nuclei showed strong association younger patient age extramedullary hematopoiesis identified patients age presence extramedullary hematopoiesis correlate tdt count dual immunostaining flow cytometric analysis case showed weak expression cell markers favored normal precursor cells although tdt common marker lymphoblastic lymphoma demonstrated tdt positive cells may part inflammatory milieu infant kidneys together cytologic architectural clinical features data help avoid misinterpretation involvement lymphoblastic lymphoma leukemia
screening alcohol use disorder aud patients challenging due subjectivity involved process hence robust objective methods needed automate screening aud patients paper machine learning method proposed utilized resting state electroencephalography eeg derived features input data classify aud patients healthy controls perform automatic screening aud patients context eeg data recorded min eyes closed min eyes open conditions purpose aud patients aged matched healthy controls recruited preprocessing eeg data eeg features inter hemispheric coherences spectral power eeg delta theta alpha beta gamma bands computed involving scalp locations selection discriminant features performed rank based feature selection method assigning weight value feature according criterion receiver operating characteristics curve example feature large weight considered relevant target labels feature less weight therefore reduced set discriminant features identified utilized classification aud patients healthy controls results inter hemispheric coherences brain regions found significantly different study groups provided high classification efficiency accuracy sensitivity specificity measure addition power computed different eeg bands found significant provided overall classification efficiency accuracy sensitivity specificity measure integration eeg feature resulted even higher results accuracy sensitivity specificity measure based results concluded eeg data integration theta beta gamma power inter hemispheric coherence could utilized objective markers screen aud patients healthy controls
high levels immune activation reported people inject drugs studies relationship injection behaviors immune activation yielded mixed results part due lack control hepatitis virus analyses study hiv seronegative people inject drugs examines relationship controlling hepatitis virus viremia frequency injection positively related markers immune activation soluble hladr cells duration injection high specificity reactive protein dimer sharing injection equipment related markers studied findings suggest efforts encourage injection cessation reduction frequency positive health benefits reducing immune activation
need scalable databases raised rapidly past years researchers developers tried develop several techniques create replications partitions non relational databases however high latency distributed data centers imposed costly bottleneck system performance paper present system design non relational database tippydb provides better response time users accessing service enhance system important observation interactions people almost always happen limited geographical area demonstrate contrast nosql databases system offers considerable improvement performance distributed environment
dlv powerful system knowledge representation reasoning supports answer set programming asp logic based programming paradigm solving problems fully declarative way dlv currently widely used academy importantly fruitfully employed many relevant industrial applications similarly main stream asp systems processing input program first phase computation dlv eliminates variables thus generating ground program semantically equivalent original one significantly smaller herbrand instantiation general phase called grounding plays key role successful deployment real world contexts work present dlv brand new version intelligent grounder dlv relying solid theoretical foundations predecessor completely redesigned engineered algorithms data structures nowfeatures full support asp core standard language increased flexibility customizability significantly improved performance extensible design eases incorporation language updates optimization techniques dlvresults stable efficient asp instantiator turns full fledged deductive database system describe main features dlvand present results proper experimental activities assessing applicability performance
cryptococcosis fungal infection opportunistic behavior unusual immunocompetent patients report rare case disseminated cryptococcosis cutaneous involvement immunocompetent individual hospitalization cryptococcus gattii isolated skin lesions lung spinal fluid diagnosis disseminated cryptococcosis confirmed treatment established patient showed improvement due probable clinical severity disease possibility skin lesions may first manifestation illness prompt diagnosis must established treatment provided
aim investigate whether phase cardiac rehabilitation conducted community model shared care including health care centres general practice feasible provided acceptable results compare hospital based randomised controlled trial methods patients randomised admission acute coronary syndrome general practitioner took responsibility remaining rehabilitation pharmacological treatment risk factor management initial visit hospital outpatient clinic municipal health care centres provided courses smoking cessation nutrition exercise training contributed disease education psychosocial support main endpoint adherence programme compliance lifestyle modifications results total patients screened eligible accepted participation phase completed participants full adherence programme seen versus relative risk confidence interval patients higher rates adherence dietary advice health education patients attend risk factor evaluation clinical assessment general practitioner difference risk factor improvement found exercise training declined groups conclusion adherence phase high groups improve adherence efficacy comparable effects medication risk factors thus safe effective
background zika virus newly recognized human teratogen monitoring impact birth prevalence microcephaly adverse pregnancy outcomes continue urgent need united states worldwide methods centers disease control prevention cdc activated emergency operations center zika virus outbreak response january public health leadership recognized joint coordinated effort required activities focused effects infection among pregnant women focused birth defects fetuses infants introduction zika virus americas population based birth defects surveillance occurred independently pregnancy surveillance activities results coordination pregnancy surveillance birth defects surveillance implemented cdc zika virus response represents paradigm shift conclusion coordination surveillance systems provides opportunity capture information prospective retrospective approach relatively modest investment public health infrastructure continue protect pregnant women infants ongoing response zika virus next emergent threat maternal child health wiley periodicals inc
regular systematic public transport great importance residents country city commuter routes environment users public transport track movement vehicles great difficulty given current system meet necessary criteria comply functioning transport system aim final paper show development system using zigbee arduino platforms paper shows example use technologies mentioned main advantages disadvantages emphasis communication device smooth progress order show way system could function simple mesh network created consisting coordinator routers data distribution end devices representing vehicles view results web application developed using open source tool display collected data movement nodes network
nanotechnology become important various disciplines technology science proven potential candidate various applications ranging biosensors delivery genes therapeutic agents tissue engineering scaffolds every application tailor made appropriate physicochemical properties influence vivo system desired way highly sensitive precise detection specific signals pathogenic markers sensing levels particular analytes fabricating target specific nanomaterials useful multi functional nano devices fabricated using different approaches achieve multi directional patterning scaffold ability alter topographical cues scale less equal smart nanomaterials made understand surrounding environment act accordingly either protecting drug hostile conditions releasing payload intended intracellular target site achieved exploiting polymers functional groups incorporating conducting materials natural biopolymer obtain smart material used detection circulating tumor cells detection differences body analytes repair damaged tissue acting cell culture scaffold nanotechnology changed nature diagnosis treatment biomedical field review aims bring together recent advances smart nanomaterials
many studies shown media violence effect children subsequent aggression study expands upon previous research three directions examining several subtypes aggression verbal relational physical measuring media violence exposure mve across three types media measuring mve aggressive prosocial behaviors two points time school year study grade children peers teachers surveyed children consumption media violence early school year predicted higher verbally aggressive behavior higher relationally aggressive behavior higher physically aggressive behavior less prosocial behavior later school year additionally effects mediated hostile attribution bias findings interpreted within theoretical framework general aggression model aggr behav wiley liss inc
theory mind tom thought play key role social information processing refers ability individuals represent mental states others intentions desires beliefs provocative hypothesis put forward espouses existence two tom systems one implicit involves automatic analysis belief states others another automatic involved explicitly reasoning others mental states recently phillips suggested limited evidence automatic tom processing identifying confound previous high profile paper supporting existence cognitive operation infants adults kovacs teglas endress take broader view literature find contrary conclusions phillips substantial body literature demonstrates adult humans able engage unconscious unintentional thus automatic analyses others mental states however whether ability best described one two multiple systems tom account remains determined elsevier rights reserved
effectiveness long perforated exit regions reducing radiation micro pressure waves mpws railway tunnels assessed disturbances always occur amplitudes usually small particular case high speed trains reach levels would cause annoyance absence suitable countermeasures risk especially large case long tunnels general behaviour wave reflection transmission radiation perforated exit region explored previous papers quantified dependence characteristics incident wavefront reaching exit region upstream tunnel validated numerical methodology searching manner notable differences found comparison criteria long known unperforated exit regions particular resulting mpw amplitudes depend amplitudes incident wavefronts well steepnesses paper summarises outcomes uses methodology explore important practical design issues namely dependence effectiveness perforated exit regions length cross sectional area differences found behaviour unperforated regions
computer aided diagnosis cad systems constitute powerful tool early diagnosis alzheimer disease limitations interpretability performance exist work fully automatic cad system based supervised learning methods proposed applied segmented brain magnetic resonance imaging mri alzheimer disease neuroimaging initiative adni participants automatic classification proposed cad system possesses two relevant characteristics optimal performance visual support decision making cad built two stages first feature extraction based independent component analysis ica class mean images secondly support vector machine svm training classification obtained features classification offer full graphical representation images giving understandable logic cad output increase confidence cad support proposed method yields classification results accuracy sensitivity specificity normal controls patients accuracy sensitivity specificity mild cognitive impairment mci accuracy sensitivity specificity mci patients
typical spinel ferrites cofeo mnfeo studied heterogeneous catalysts peroxymonosulfate pms degradation paracetamol apap water apap degradation followed pseudo first order kinetics pattern conditions tested presence catalyst apap initial concentration would removed cofeo pms mnfeo pms system respectively higher catalyst dosage higher pms dosage neutral lower concentration favored apap degradation system recycled three times mnfeo cofeo could still effectively catalyze pms react apap removal efficiencies respectively production sulfate radical hydroxyl radical validated scavenging tests results showed sulfate radical main reactive species responsible apap degradation plausible mechanisms activation processes proposed based radical identification tests xps analysis showing recycle recycle catalyst responsible radical generation results demonstrated cofeo mnfeo mnps activated pms promising technologies water pollution caused pharmaceuticals elsevier rights reserved
objectives previously shown association several chronic somatic diseases climacteric related symptoms time investigated whether self rated health srh contributes association methods women health questionnaire used evaluate climacteric related symptoms existence diseases investigated women years previous study associations defined multivariable analyses present study srh good moderate bad included covariate results previously found associations diseases symptoms lost significance accordingly srh played important role association diseases symptoms related climacteric conclusions srh seems significant importance regarding relationship chronic somatic diseases symptoms related climacteric diseases associated climacteric related symptoms disease deteriorate srh thus women perception health crucial symptomatology
reporting ecological phenomena environmental status routinely required point observations collected traditional sampling approaches extrapolated larger reporting scales process encompasses difficulties quickly entrain significant errors remote sensing techniques offer insights exceptional spatial coverage observing marine environment review provides guidance structures discontinuities inherent within extrapolative process extrapolate effectively across multiple spatial scales iii remote sensing techniques data sets facilitate process evaluation illustrates remote sensing techniques critical component extrapolation likely underpin production high quality assessments ecological phenomena regional reporting environmental status ultimately hoped guidance aid production robust consistent extrapolations also make full use techniques data sets expedite process elsevier ltd rights reserved
modern understanding cerebral cortical lesions develop acute brain injury based aristides tilde historic discoveries spreading depression asphyxial anoxic depolarization treated separate entities decades appreciate events define continuum spreading mass depolarizations concept central understanding pathologic effects within minutes acute severe ischemia onset persistent depolarization triggers breakdown ion homeostasis development cytotoxic edema persistent changes diagnosed diffusion restriction magnetic resonance imaging define ischemic core delayed lesion growth transient spreading depolarizations arise spontaneously ischemic penumbra induce persistent depolarization excitotoxic damage progressively expanding ischemic core causal role waves lesion development proven real time monitoring electrophysiology blood flow cytotoxic edema spreading depolarization continuum applies models acute cortical lesions suggesting universal principle cortical lesion development pathophysiologic concepts establish working hypothesis translation human disease complex patterns depolarizations observed acute brain injury appear mediate signal ongoing secondary damage
wave overtopping one key parameters designing coastal structures crest level usually determined using admissible overtopping discharges several formulae already exist wave overtopping assessment predict average overtopping discharge per meter width coastal defence generally deep intermediate water depths toe dike however process wave overtopping sea dikes shallow shallow foreshore yet fully understood gentle foreshores combination shallow water conditions lead heavy wave breaking significant change wave spectra offshore toe dike wave steepness assumed one main criteria identify cases severe wave breaking shallow shallow foreshores conditions van gent formula generally used wave overtopping shallow foreshores implemented validated experimental data purpose paper show van gent formula overestimates average overtopping discharge cases shallow foreshores moreover existing formula applied cases emergent toe present work therefore introduces new equivalent slope concept obtain estimation average wave overtopping discharges sea dikes shallow shallow foreshores study uses data clash database experimental campaigns specifically carried flanders hydraulics research belgium order validate approach results indicate concept shows better performance compared empirical formulae suggests influence shallow foreshore average wave overtopping discharge included elsevier rights reserved
cutting punching electrical steel cause edge burrs lead interlaminar short circuits laminations paper based equivalent electric circuit eddy current path analytical method developed estimate eddy current power loss magnetic cores caused interlaminar faults wide range flux density magnetizing frequency important factors skin effect nonuniform flux density distribution complex relative permeability nonlinear relation often neglected literature highlighted fundamental concepts interlaminar fault consequences effect interlaminar faults configuration magnetic cores finite element method verification presented part paper modeling eddy current together experimental results eddy current measurements packs shorted laminations reported part
purpose src homology domain containing adaptor protein shb widely expressed immune cells acts important regulator hematopoietic cell function shb silencing induces immunity mice shb also involved cell homeostasis vivo however shb yet studied addressed association dendritic cells dcs materials methods effects shb expression immunogenicity dcs assessed shb gene silencing mouse bone marrow derived dcs bmdcs silencing surface phenotype cytokine expression profile cell stimulation capacity bmdcs examined investigated signaling pathways involved shb expression bmdc development also examined immunogenicity shb knockdown shbkd bmdcs mouse atopic dermatitis model results shb steadily expressed mouse splenic dcs vitro generated bmdcs immature mature stages shb expression contingent activation mitogen activated protein kinase foxa signaling pathway development shbkd increased expression mhc class costimulatory molecules without affecting cytokine expression bmdcs cultured cells shbkd bmdcs significantly induc cell proliferation expression cytokines regulatory cell treg population downregulated mouse atopic dermatitis model mice inoculated shbkd dcs developed severe symptoms atopic dermatitis compared mice injected control dcs conclusion shb expression dcs plays important role cell homeostasis vivo regulating mediated polarization
paper presents method detecting anomalous power consumption patterns attacks using discrete wavelet transform well variance fractal dimension vfd artificial neural network ann smart grid main procedure proposed algorithm consists following steps finding normal anomalous patterns power consumption train proposed method applying wavelet transform power consumption patterns extract features iii applying vfd extracted features step input training ann extracted features step launching trained ann step detect anomalous power consumption attack based threshold proposed method detect anomalous power consumption attack accuracy worst case scenario
patients receive preferred beta lactam therapy due reported beta lactam allergy increased number adverse events compared patients without reported history beta lactam allergy methods aeuro integral conducted trainee led prospective cohort study determine burden clinical impact reported beta lactam allergy patients seen infectious diseases consultation services academic hospitals primary outcome composite measure readmission infection acute kidney injury clostridium difficile infection drug related adverse reactions requiring discontinuation predictors interest history beta lactam allergy receipt preferred beta lactam therapy results aeuro integral among patients reported beta lactam allergy preferred therapy beta lactam beta lactam therapy preferred receive preferred therapy due report allergy even though reported non severe prior reactions adjustment confounders patients receive preferred beta lactam therapy greater risk adverse events adjusted odds ratio aor confidence interval compared without reported allergy contrast patients received preferred beta lactam therapy similar risk adverse events compared patients reporting allergy aor conclusions aeuro integral avoidance preferred beta lactam therapy patients report allergy associated increased risk adverse events development inpatient programs aimed accurately identifying beta lactam allergies safely promote beta lactam administration among patients warranted
genome wide association studies frontotemporal dementia showed limited success identifying associated loci possibly due small sample size allelic heterogeneity small effect sizes single genetic variants necessity statistically correct testing millions genetic variants overcome issues performed gene based association studies clinically identified frontotemporal dementia cases controls discovery replication joint cohort analyses report association apoe tomm behavioural variant frontotemporal dementia arhgap serpina progressive non fluent aphasia found epsilon epsilon alleles apoe harbouring protective risk increasing effects respectively clinical subtypes frontotemporal dementia neurologically normal controls apoe locus association behavioural variant frontotemporal dementia indicates potential risk increasing role across different neurodegenerative diseases whereas novel genetic associations arhgap serpina progressive non fluent aphasia point towards potential role stress signalling pathway pathophysiology
objectivescisplatin ototoxicity affects treated children catechol methyltransferase comt thiopurine methyltransferase tpmt aycp genetic variants associated ototoxicity findings contradictory aims study follows investigate associations carefully phenotyped cohort children perform systematic review meta analysis methodswe recruited children seven centres using retrospective cohort study design participants clinically phenotyped carefully genotyping performed one acyp three tpmt two comt variants resultsfor ctcae grading hearing loss present worst ear better ear using chang grading hearing loss diagnosed worst ear versus better ear tpmt comt single nucleotide polymorphisms snps associated ototoxicity acyp snp associated ototoxicity worst ear meta analysis data reported previous studies showed pooled odds ratio statistically significant comt snp confidence interval acyp snp confidence interval conclusionwe showed association acyp polymorphism cisplatin induced ototoxicity tpmt comt meta analysis statistically significant comt acyp snps grading hearing children asymmetric hearing loss requires additional clarification
backgroundopioid misuse large public health problem united states residents rural areas american indian reservation trust lands represent traditionally underserved populations regard substance use disorder therapy purposeassess differences number opioid agonist therapy oat facilities physicians drug addiction treatment act data waivers rural versus urban reservation trust land versus non reservation trust land areas washington state methodsthe unit analysis zip code dependent variables number oat facilities data waivered physicians region per residents aged zip code region defined zip code contiguous zip codes independent variables binary measures whether zip code classified rural versus urban reservation trust land versus non reservation trust land zero inflated negative binomial regressions robust standard errors estimated resultsthe number oat clinics region per zip code residents significantly lower rural versus urban areas differ significantly reservation trust land non reservation trust land areas data waivered physicians region per zip code residents significantly different rural urban reservation trust land versus non reservation trust land areas conclusionsit appears potential washington state residents rural reservation areas receive oat similar residents outside areas however difficulties accessing therapy may remain highlighting importance expanding health care insurance providing support data waivered physicians
one candidate tritium breeding blankets chinese fusion engineering test reactor cfetr conceptual structure helium cooled solid breeder blanket recently proposed neutronic thermal hydraulic mechanical characteristics blanket directly affect tritium breeding safety performance therefore neutronic thermal hydraulic mechanical coupling analyses vital importance reliable blanket design work first three dimensional neutronics analysis optimization typical outboard equatorial blanket module performed comprehensive optimal scheme thermal fluid dynamic analyses scheme normal critical conditions performed coupled previous neutronic calculation results thermal hydraulic boundaries thermo mechanical analyses structure materials normal critical blanket pressurization conditions carried addition several parametric sensitivity studies also conducted investigate influences main parameters blanket temperature distributions paper coupled analyses verify reasonability optimized conceptual design preliminarily provide important reference analysis optimization design cfetr helium cooled solid breeder blanket cfetr elsevier rights reserved
attention deficit hyperactive disorder adhd one common mental health disorders amongst school aged children estimated prevalence global population american psychiatric association stimulants particularly methylphenidate mph first line option treatment adhd reeves schweitzer dopheide pliszka prescribed increasing number children adolescents every year safer mccarthy though recent studies suggest tailing holden around children demonstrate clinically significant treatment response stimulant medication spencer schachter swanson barbaresi however unclear patient characteristics may moderate treatment effectiveness existing research focused investigating univariate multivariate correlations set patient characteristics treatment outcome respect dosage one several types medication results studies often contradictory inconclusive due combination small sample sizes low quality data lack available information covariates paper feature extraction techniques latent trait analysis applied reduce dimension large dataset patient characteristics including responses symptom based questionnaires developmental health factors demographic variables age gender socioeconomic factors parental income introduce bayesian modeling approach learning model space framework combines existing knowledge literature factors may potentially affect treatment response constraints imposed treatment response model model personalized variability among subjects accounted set subject specific parameters remission classification approach compares favorably conventional methods support vector machines mixed effect models range performance measures instance proposed approach achieved area receiver operator characteristic curve compared obtained conventional regression machine learning learning data space methods
objective explore characteristics long acting reversible contraception larc users nationally representative cohort young australian women aged methods data women responded question contraceptive use previous six months baseline contraceptive use pregnancy intention decisions cupid survey included results women reported larc use implanon popular method history pregnancy strongly associated increased odds larc use multivariate model comparatively using contraception reasons pregnancy prevention associated decreased odds larc use multivariate model period management body management medical condition highest education medicare card status also contributed final multivariate model associated decreased odds larc use conclusion reproductive history reasons contraceptive use strong indications method choice promoting larc highly effective may sufficient incentive young women take method pregnancy prevention may equal secondary desired non contraceptive effects elsevier rights reserved
next generation wireless local area networks wlans enhanced throughput performance attracted significant amounts attention recent years based ieee standard frame aggregation considered one major factors improve system performance wlans medium access control perspective order fulfill requirements high throughput performance feasible design automatic repeat request arq mechanisms considered important providing reliable data transmission paper aggregated selective repeat arq asr arq algorithm proposed incorporate conventional selective repeat arq scheme consideration frame aggregation novel analytical model based signal flow graph established order realize behaviors asr arq algorithm simulations also conducted validate effectiveness proposed asr arq mechanism
neuroimaging studies demonstrated major depression disorder would increase risk dementia older amnestic cognitive impairment used granger causality analysis algorithm explore amygdala hippocampus based directional connectivity patterns patients major depression disorder amnestic cognitive impairment mean age years amnestic cognitive impairment patients mean age years healthy controls mean age years compared amnestic cognitive impairment patients control groups respectively patients major depression disorder amnestic cognitive impairment displayed increased effective connectivity right amygdala right lingual calcarine gyrus well bilateral supplementary motor areas meanwhile patients major depression disorder amnestic cognitive impairment enhanced effective connectivity left superior parietal gyrus superior middle occipital gyrus left hippocampus values also correlated scores mini mental state examination auditory verbal learning test immediate recall findings indicated directional effective connectivity right amygdala occipital parietal lobe left hippocampus might pathway major depression disorder inhibited brain activity patients amnestic cognitive impairment
objectives test performance single weighted sequence compared whole body mri protocol including dwi weighted stir pediatric population methods two radiologists years experience reviewed wbmris first stir alone weeks later protocol indications variable positive findings explicitly reported third reader compared results gold standard exams specific pathology agreement two readers sensitivity positive predictive value stir calculated results fifty four wbmris included suspected child abuse chronic recurrent multifocal osteomyelitis crmo lymphomas osteosarcomas neuroblastomas histiocytosis mean age years months range month years agreement readers stir protocol reader sensitivity stir reader stir readers protocols positive predictive value ppv depended type disease example histocytosis osteosarcomas child abuse crmo lymphoma neuroblastoma conclusions sensitivities different protocols reader different readers protocol elsevier rights reserved
paper aims investigate impact built environment emerging transit car technologies household transport related greenhouse gas emissions ghgs across three urban regions trip level ghg emissions first estimated combining different data sources origin destination surveys vehicle fleet fuel consumption rates transit ridership data indicators different urban regions generated household impact neighborhood typologies derived based indicators traditional ordinary least square ols regression approach used investigate direct association indicators socio demographics household ghgs effect neighborhood typologies ghgs explored using ols simultaneous equation modeling approach best models determined urban region potential impact determined elasticities compared impact technological improvements various fuel efficiency scenarios formulated reductions household ghgs determined potential impact green transit car technologies determined results compared related initiatives among results found attributes statistically significant effect ghgs however elasticities small reported several previous studies instance increase population density result reduction montreal quebec sherbrooke respectively also important highlight significant variation household ghgs among neighborhoods city variation much greater among cities short term improvements private passenger vehicle fleet expected much significant green transit technologies however combined effect strategies private motor vehicle technological improvement would result significant ghgs reductions long term
power systems variable renewable sources gas generation playing increasingly prominent role providing short term flexibility meet net load requirements flexibility provided gas turbines turn relies flexibility gas network several discussions ability gas network providing operational flexibility clearly modeled quantified addition gas network may also responsible supplying heating technologies low carbon scenarios see tighter interaction electricity heating gas sectors calls holistic multi energy system assessment premises paper presents original methodology quantify flexibility gas network provide power system well constraints may impose also consideration different heating scenarios achieved novel multi stage integrated gas electrical transmission network model uses electrical opf steady state transient gas analyses novel metric makes use concept zonal linepack also introduced assess integrated gas electrical flexibility used impose gas related inter network inter temporal constraints electrical opf case studies performed great britain transmission system different renewables heating scenarios demonstrate proposed integrated flexibility assessment methodology provide insights effects changes heating sector multi energy system combined flexibility requirements capability assess electrical network experience local generation reserve constraints related gas network lack flexibility
experimental autoimmune neuritis ean cluster differentiation helper cell mediated inflammatory demyelinating disease peripheral nervous system serves useful animal model guillain barre syndrome triggering receptor expressed myeloid cells trem important receptor involved sepsis innate inflammatory response linear plasmid peptide competitive antagonist trem investigate role trem ean male lewis rats randomly divided four groups normal saline complete freund adjuvant ean present study assessed mrna expression levels trem tumor necrosis factor alpha interleukin beta sciatic nerves peripheral blood mononuclear cells results demonstrated inhibiting trem administering ameliorated symptoms reduced inflammation ean rats present study concluded trem may involved pathogenesis ean inhibition trem may ameliorate ean
low health literacy emerged important area research dose link health disparities study used qualitative approach investigate healthcare providers perspectives health literacy immigrant refugee parents association children health sixteen health mental health professionals serving immigrant refugee parents children various clinical settings recruited purposive sampling method interviewed six broad themes identified multi dimensional components parental health literacy parent characteristics native country experiences host systems interactions impact parental health literacy diverse aspects help seeking culture based parental help seeking child health outcomes within larger themes complexity parental health literacy various effects children health outcomes among immigrant refugee parents evident future research includes population based quantitative studies parental health literacy culturally relevant clinical approaches among immigrant refugee parents published elsevier ltd
objective review attempt characterize acute chronic role htb receptors regard meningeal nociception animal experiments clinical data targeting migraine therapy background migraine common disabling neurovascular primary headache disease pathomechanism still unclear serotonin receptors might play important role aspects migraine pathogenesis ability unselective htb receptor agonist chlorophenylpiperazine induce migraine attacks migraine sufferers high affinity prophylactic antimigraine drugs receptor expression migraine relevant structures like dura mater argue role htb receptors pathogenesis migraine attacks methods review relevant databases pubmed medline cochrane library embase respectively searched december using keywords migraine trigeminal neurogenic inflammation nitric oxide nitroxyl vasodilatation plasma protein extravasation combinations thereof conclusion literature review suggests important role htb receptor activation meningeal nociception generation migraine pain
study combines electricity supply mix profiles observed charging behaviour compare environmental performance petrol hybrid electric vehicle phev class equivalent internal combustion engine ice vehicle full life cycle environmental performance compared using suite indicators across life cycle accounting marginal average electricity supply mixes australia national energy market nem grid use average emission factors nem grid serve good proxy accounting charging behaviour provided strong correlation time charging total electricity demand compared equivalent ice phevs charged australia nem reduce greenhouse gas emissions life cycle potential burden shifts towards acidification eutrophication human toxicity impacts may occur impacts uncertain due modelling limitations study potential inform short long term forecasts environmental impacts associated deployment australia provides better understanding temporal variations emissions associated electricity use short term elsevier ltd rights reserved
adsorption methane twelve microporous carbon adsorbents different origin structural energy characteristics studied pressures mpa specific capacities calculated methane adsorption storage systems effectiveness adsorption accumulation analyzed terms structural energy characteristics packing density thermodynamic parameters methane adsorption differential molar isosteric heats adsorption absolute efficiency adsorption accumulation systems evaluated effects increased packing density proper shape adsorbent material adsorption accumulation efficiency considered shown selection adsorbent optimal porous structure density adjusted thermodynamic parameters accumulation system
permeable pavements increasingly used urban stormwater management systems permeable pavement systems enable stormwater infiltrate pavement surface filter layer three common recycled construction demolition materials crushed brick recycled concrete aggregate rca reclaimed asphalt pavement rap investigated combination nonwoven geotextile assess suitability filter materials permeable pavements series laboratory tests undertaken assess geotechnical hydraulic characteristics materials permeable pavement applications worst case scenario stormwater mixtures prepared laboratory slightly higher average pollutant concentrations stormwater runoff events occurring urban areas constant head permeability tests carried investigate stormwater filtration capacity clogging behaviour materials series hydraulic conductivity tests also conducted investigate effect variations properties filter media sediment particle sizes density filter media clogging effects time research found geotextile layer increases pollutant removal efficiency materials however potential cause clogging due continuous accumulations sediments long period terms usage permeable pavement filter layer materials found geotechnical hydraulic properties equivalent superior typical quarry granular materials model urban stormwater improvement conceptualisation music furthermore employed predict pollutant removal efficiency materials predicted results validated laboratory experiments elsevier ltd rights reserved
graphite nanoparticles originated high purity graphite crucible used deoxidization purification libef molten salt containing bit bef high temperature vacuum condition mechanism deoxidization purification via graphite nanoparticles put forward based analysis sample characterization chemical reaction gibbs free energy calculation morphology particle size chemical composition crystal structure graphite nanoparticles libef molten salt characterized high resolution transmission electron microscopy hrtem saed eds phase analysis total oxygen content full elemental anion concentration prepared libef products studied ray diffraction xrd leco nitrogen oxygen analyzer inductively coupled plasma optical emission spectrometry icp oes ion chromatography respectively results sample characterization showed graphite nanoparticles libef molten salt poly crystal round sheet shape average diameter concentration total oxygen sulfur nickel prepared libef molten salt treatment ppm ppm ppm respectively experiment calculation showed could react carbon degrees vacuum degassing play excellent role deoxidization purification libef molten salt via graphite nanoparticles elsevier rights reserved
biologic therapies including stem cells platelet rich plasma growth factors biologically active adjuncts recently received increased attention basic science clinical literature aossm biologics think tank held colorado springs colorado group orthopaedic surgeons basic scientists veterinarians investigators gathered review state science biologics barriers implementation biologics treatment sports medicine injuries series current concepts reviews reports summary scientific presentations roundtable discussions recommendations think tank
understand current literature age related neural detrusor changes associated overactive bladder symptoms recent functional magnetic resonance imaging fmri studies unveiled age related decrease neural control continence represented insula anterior cingulate cortex acc prefrontal cortex pfc older individuals overactive bladder symptoms also demonstrate heightened activation acc low volumes representing increased bladder sensitivity sense urgency level bladder age related changes urothelium neurotransmitters receptors muscarinic purinergic inflammation including nerve growth factor ngf monocyte chemoattractant protein mcp oxidative stress also associated overactive bladder overactive bladder among older adults complex condition incorporating physiologic age related changes brain bladder beyond
purpose study done develop evidence based incontinence care protocol adaptation process evaluate effects protocol methods protocol developed according guideline adaptation non randomized controlled trial used testing effects new incontinence care protocol total patients bowel incontinence bristol stool type admitted intensive care units recruited study newly developed incontinence care protocol used patients experimental group conventional skin care given patients control group outcome variables incontinence associated dermatitis iad severity pressure ulcer occurrence severity results experimental group significantly less severe iad lower occurrence pressure ulcers less severity pressure ulcers mann whitney control group conclusion use incontinence care protocol effects preventing pressure ulcers inhibiting worsening iad pressure ulcers therefore incontinence care protocol expected contribute managing iad pressure ulcers
purpose study national institutes health calls research explores means age optimally hiv aids half people hiv aged older study applied stress process model examine association hiv stigma psychological well mediating resources spirituality complementary integrative health cih approaches older adults hiv design methods using data research older adults hiv roah study structural equation modeling used estimate relationships within latent variable model namely direct negative association hiv stigma psychological well hypothesized would mediated spirituality cih use results analyses showed model fits data well comparative fit index root mean square error approximation confidence interval observed variables significantly loaded latent factor paths significant results indicated spirituality cih use significantly mediated negative association hiv stigma psychological well implications findings highlight importance spiritual cih interventions older adults hiv aids practice recommendations provided micro mesolevel
era science technology plays crucial role healthcare sensing devices moreover communication storing processing display devices advances various streams sensing techniques nanotechnologies embedded systems wireless communication networks miniaturization resulting evolve intelligent systems monitor control various medical parameters post operational days hence iot internet things emerged recent trend healthcare communication systems iot serves catalyst healthcare plays major role numerous healthcare applications wearable sensors recognize anomalous unforeseen conditions examining physiological parameters along symptoms transfers vital signs medical evaluation hence prompt provisional medication done immediately avoid severe conditions proposed system microcontroller used gateway communicate several sensors depending parameters monitored pulse rate counter temperature sensor accelerometer etc microcontroller acquires sensor data processes transmits network appropriate data transmission protocol successively providing real time monitoring healthcare parameters healthcare professionals doctor access data anytime simply logging html hypertext markup language webpage typing corresponding unique internet protocol address internet browser
utilization link transmission corridor embedded vsc hvdc power injection renewable energy sources increase power flow capability network stability support promising technology however faults transmission line likely threaten system operation stability especially power injection exceeds certain limits single line earth fault likely fault scenario effect vsc hvdc operation depend earth loop impedance adding injection point link reduce earth loop impedance hence imposing danger increasing earth fault current therefore paper vsc hvdc power injection link studied line earth fault analyzed time domain effects sides system presented analysis based developed state space representation system single line earth fault zero input zero state zizs response used find solution state space representation order correlate state space solution simulation system modeled matlab simulink interestingly observed quick recharging link capacitor due power injection created additional damping postfault oscillations
investigated role self focused attention sfa social anxiety disorder ecologically valid way experiment high versus low socially anxious single women years video slcype conversation attractive male confederate seeing confederate screen conversation divided four phases warm positive confederate friendly participant iii critical confederate critical participant active participant instructed ask questions confederate participant sfa measured eye tracked gaze duration image relative confederates video image places computer screen results show high socially anxious participants self focused critical phase less self focused active phase low socially anxious participants experiment women diagnosed sad controls years conducted experiment compared controls participants sad showed increased sfa across four phases conversation sfa predicted increased self rated anxiety conversation conclusion subclinical social anxiety sfa high interaction partner critical whereas instructions ask questions confederate reduces subclinical socially anxious sfa clinical sad characterized heightened self focused attention throughout interaction results support theories social anxiety disorder maintained sfa imply interventions lower sfa may help prevent treat social anxiety disorder sfa also adaptive certain types interaction receiving compliments elsevier ltd rights reserved
arsenic contamination communal tubewells prey veng cambodia observed since many wells exceed drinking water standard factor aim study assess cooking water source impacts dietary intake rural community prey veng aim fulfilled using geostatistical analysis techniques examine extent contaminated groundwater prey veng identify suitable study site conducting site study two villages measure content cooked rice prepared water collected tubewells locally harvested rainwater determining dietary intake consuming rice geostatistical analysis indicated high risk tubewells concentrated along mekong river east bank participants using high risk tubewells consuming times inorganic daily recommended previous fao provisional tolerable daily intake value kgbw day however content rice cooked rainwater significantly reduced therefore considered safer sustainable option region crown copyright published elsevier rights reserved
digital converter ddc time intensive data intensive computing task considered key technology software defined radio paper proposes high performance implementation ddc graphics processing unit gpu using cuda composed numerically controlled oscillator stage cascaded integrator comb cic decimation filter stage finite impulse response fir filter stage gpu implementation optimizing stages studied detail additionally handling long duration signal signal data sequence truncated segments overlap save overlap add mechanisms applied cic stage fir stage respectively finally experiments conducted evaluate performance gpu based ddc respect sequential version cpu implementation openmp implementation threads experimental results demonstrate ddc achieves significant improvements gpu maximum speed ups numerically controlled oscillator stage cic stage fir stage achieve times including data transfer kernel execution processing operations overall speed ddc achieve meantime speed ups gpu implementation far openmp implementation times
symptoms antisocial personality disorder aspd particularly remorselessness frequently introduced legal settings risk factor future violence prison despite paucity research predictive validity disorder examined whether aspd diagnosis symptom criteria counts could prospectively predict form institutional misconduct well aggressive violent infractions among newly admitted prisoners adult male female offenders recruited prison systems across united states time study enrollment diagnostic information collected using structured clinical interview diagnostic statistical manual mental disorders dsm apa axis personality disorders scid first gibbon spitzer williams benjamin supplemented detailed review official records disciplinary records obtained inmates respective prisons covering year period following study enrollment misconduct categorized hierarchically general aggressive verbal physical violent physical dichotomous aspd diagnoses adult symptom criteria counts significantly predict institutional misconduct across outcome variables effect sizes close magnitude symptom remorselessness particular showed relation future misconduct prison childhood symptom counts conduct disorder demonstrated modest predictive utility results offer essentially support claim aspd diagnoses predict institutional misconduct prison regardless number adult symptoms present forensic contexts testimony aspd diagnosis identifies defendants pose serious threat incarcerated prison presently lacks substantial scientific foundation
diffuse large cell lymphoma dlbcl common type non hodgkin lymphoma comprises approximately lymphomas patients typically present nonpainful mass neck groin abdomen associated constitutional symptoms report however authors describe rare case year old woman hyperprolactinemia hypothyroidism acromegaly elevation insulin like growth factor igf elevated growth hormone releasing hormone ghrh mri demonstrated diffuse enlargement pituitary gland despite medical treatment patient persistent elevation igf underwent transsphenoidal biopsy yielded diagnosis dlbcl activated cell immunophenotype somatotroph hyperplasia stereo tactic radiation therapy combination chemotherapy currently remission lymphoma normalized igf levels without medical therapy months histopathological diagnosis reported case kind displays importance broad differential diagnosis multidisciplinary evaluation critical intraoperative decision making treating atypical sellar lesions
background depressed individuals often exhibit impaired inhibition negative input identification positive stimuli unclear whether state trait feature exploited naturalistic model namely individuals seasonal affective disorder sad study feature longitudinally aim goal study examine seasonal changes inhibitory control identification emotional faces individuals sad method twenty nine individuals diagnosed winter sad demographically matched controls seasonality symptoms completed emotional nogo task requiring inhibition prepotent responses emotional facial expressions emotional face identification task twice winter summer results winter individuals sad showed impaired ability inhibit responses angry sad faces decreased identification happy faces compared controls summer individuals sad controls performed similarly tasks conclusion provide novel evidence inhibition angry sad faces identification happy faces impaired sad symptomatic phase remitted phase affective biases cognitive processing constitute state dependent features sad data show reinstatement normal affective cognition possible would constitute major goal psychiatric treatment improve quality life patients
linear regression models depend directly design matrix properties techniques efficiently estimate model coefficients partitioning rows design matrix increasingly becoming popular large scale problems fit well modern parallel computing architectures propose simple measure concordance design matrix subset rows estimates well subset captures variance covariance structure larger data set illustrate use measure heuristic method selecting row partition sizes balance statistical computational efficiency goals real world problems
method enables evaluation new construction machine concepts diesel electric hybrid construction machines presented method unbiased control engineer experience development time tuning algorithms concept impact inconsistent operator behavior deviations complete machine tests also minimized method based dynamic programming finds global optimum regards fuel efficiency ton given productivity ton concept enable objective comparison concepts method system optimization included ensures concept evaluated optimal setup component sizes within boundary conditions set machine performance requirements two different diesel electric hybrid machine concepts including drive line working hydraulics investigated parallel hybrid series hybrid compared conventional machine main focus evaluating concepts different control algorithms machine models based conventional machine wheel loader used example due complex nature system driveline working hydraulics work together throughout work cycle interaction gravel pile bucket also considered order simulate optimize complete work cycle wheel loader bucket application performing short loading cycle part production chain used example common application larger wheel loaders hence important application optimize main result method algorithms presented paper works additional results show parallel hybrid wheel loader approximately higher fuel efficiency series hybrid approximately higher comparing conventional machine investigated application system optimization shows example correctly sized genset internal combustion engine electrical machine series hybrid improve fuel efficiency approximately application comparison optimal downsized genset genset size internal combustion engine conventional machine method presented also used complex machines agriculture forestry road vehicles
manufacturing engineering supposed provide analyses related various aspects manufacturing production order maximise technological energy economic gains relevant production processes present paper gives recapitulation several publications present authors presenting considerations energy efficiency biofuel production energy efficiency understood ratio energy obtained biofuels produced basing crops particular area energy required satisfy needs subsidiary processes assuring correct functioning production system starting operations aimed obtain agricultural crops ending conversion crops onto biofuels derived present authors mathematical model energy efficiency biofuel production extended general form applied analysis quantitative relations energy efficiency energy plantations elements biofuel production system converting harvested biomass biofuel investigations aimed towards determination role biomass source energy
background diminished physical mental health related quality life hrqol common consequence road traffic crash rtc injury study aimed determine probable recovery trajectories physical mental hrqol examine impact posttraumatic stress disorder ptsd hrqol scores within trajectory groups examine influence predictor covariates trajectory group membership methods female age injured rtc survivors completed approximately months sustaining rtc injury participants also completed telephone interviews assess prior history psychological disorder current ptsd wave results three trajectories identified physical component score pcs gradual recovery low improving severe chronic four trajectories defined sfv mental component score mcs unaffected severe improving severe declining low improving ptsd diagnosis significantly reduced sfv component scores trajectories associated poorer outcome age predictive trajectory group membership pcs whereas injury severity predictive trajectory group membership mcs limitations use compensation seeking sample affects generalizability general rtc population conclusions study identified concerning subgroup individuals chronic declining physical mental hrqol impacted diagnosis ptsd development interventions special focus associated psychological injury needed improve hrqol risk individuals following rtc injury
invasive fungal infection problem continues challenge healthcare sector new antifungals new therapeutic strategies needed address challenge previously reported combination synthetic compound drug known mechanism action good strategy treat aggressive resistant fungi revisited approach synthesized structural analogues flucytosine synthetic antifungal studied use combination therapy antifungal drugs pyrimidin one thione often known dhpm flucytosine analogues obtained biginelli reaction corresponding aldehydes ethylacetoacetate urea thiourea structure confirmed ftir hnmr cnmr cosy esi analysis newly synthesized derivatives evaluated antifungal activity alone combination two commonly used antifungal drugs amphotericin fluconazole different clinically isolated candida albicans strains minimum inhibitory concentration results confirmed possess high antifungal activity tested strains mic combinations amphotericin fluconazole synergistic followed additive indifferent interactions interestingly antagonistic interaction observed combined fluconazole however antagonistic interaction observed amphotericin depth studies synergies done constructing isobolograms nine different ratio combinations results warrant use dhpm derivatives chemosensitising agents could lower dosages antifungal drugs treat invasive fungal diseases elsevier ltd rights reserved
implicit moral evaluations immediate unintentional assessments wrongness actions persons play central role supporting moral behavior everyday life yet little research employed methods rigorously measure individual differences implicit moral evaluations five experiments develop new sequential priming measure moral categorization task multinomial model decomposes judgment task multiple component processes include implicit moral evaluations moral transgression primes unintentional judgment accurate moral judgments target actions intentional judgment directional tendency judge actions morally wrong response bias speeded response deadlines reduced intentional judgment unintentional judgment experiment unintentional judgment stronger toward moral transgression primes non moral negative primes experiments intentional judgment associated increased error related negativity neurophysiological indicator behavioral control experiment finally people voted anti gay marriage amendment stronger unintentional judgment toward gay marriage primes experiment across experiments implicit moral evaluations converged moral personality unintentional judgment wrong primes negative primes negatively associated psychopathic tendencies positively associated moral identity guilt proneness theoretical practical applications formal modeling moral psychology discussed elsevier rights reserved
studies carbon dioxide emissions provincial level provide scientific basis optimal use energy formulation reduction policies studied variation emissions primary energy consumption influencing factors based data xinjiang uygur autonomous region calculated according ipcc guidelines national greenhouse gas inventories xinjiang emission process could divided five stages according growth rates total amount emissions emission intensity impact factors quantitatively analyzed using logarithmic mean divisia index lmdi method stage various factors including government policies technological progress related role emissions comprehensively analyzed internal relationships among various factors clarified results show contribution rates various impact factors different stage overall economic growth energy consumption intensity main driving factors emissions since implementation birth control policy driving force population growth increase emissions slowly weakened energy consumption intensity affected industrial structure energy consumption intensity primary secondary tertiary industries energy consumption intensity secondary industries proportion secondary industries important factors affecting energy consumption intensity governmental policies technological progress also important factors affected emissions
objectives imperative individual differences cultural contexts adolescent mothers whose parenting often linked poor child outcomes better understood especially among puerto rican origin mothers experience high rates poverty behaviors mothers use elicit compliance children important investigate children ability engage regulated compliant behavior long term consequences adjustment study tested whether mothers orientation american latino cultures influenced associations maternal behaviors compliant defiant child behaviors method sample included young puerto rican origin mothers month old toddlers behaviors coded toy cleanup task measured maternal guidance control child compliance defiance acculturation enculturation measured self report questionnaire results maternal guidance predicted child compliance significant variations cultural orientation however mothers enculturated children compliant predicted mothers frequent use control related child defiance mothers reporting high levels acculturation less acculturated mothers conclusions findings support hypothesis individual differences cultural orientation influence variations associations certain maternal child behaviors
domestic homicide extreme form domestic violence one common types homicide objective examine differences spontaneous domestic homicide nondomestic homicide offenders regarding demographics psychiatric history crime characteristics neuropsychological status utilizing neuropsychological test data forensic examinations murderers using standard crime classification criteria committed spontaneous domestic homicides sdh committed nondomestic homicides ndh sdh offenders likely manifest psychotic disorders less likely diagnosed antisocial personality disorder prior felony convictions sdh offenders manifested significantly worse neuropsychological impairments ndh offenders mean number victims lower sdh ndh group sdh offenders used firearm whereas ndh offenders used firearm findings corroborate notion spontaneous domestic homicide may represent discernible criminological phenotype
background alzheimer disease globally prevalent neurodegenerative condition clinically characterized progressive memory loss gradual impairment cognitive functions bapineuzumab fully humanized monoclonal antibody binds neurotoxic amyloid proteins brain enhancing clearance performed systematic review meta analysis evaluate safety efficacy bapineuzumab patients mild moderate alzheimer disease methods performed web based literature search pubmed ovid ebsco scopus embase cochrane central web science using relevant keywords data extracted eligible records pooled mean difference risk ratio values confidence interval using review manager software version windows heterogeneity measured chi square square tests result pooled effect estimate six randomized clinical trials showed bapineuzumab significantly reduced cerebrospinal fluid concentration phosphorylated tau proteins standardized however bapineuzumab group superior placebo group terms change baseline alzheimer disease assessment scale adas cog disability assessment dementia dad scale mini mental state examination mmse scores regarding safety bapineuzumab increased risk serious treatment emergent adverse events cerebral vasogenic edema bapineuzumab doses similar placebo terms change baseline adas cog dad mmse scores except dose caused significant worsening adas cog scale conclusions considering lack clinical efficacy combined significant association serious adverse events bapineuzumab used treat patients mild moderate future studies investigate effect combining bapineuzumab therapeutic strategies reevaluate efficacy targeting amyloid beta proteins therapy
background nonalcoholic steatohepatitis nash known recur following liver transplantation metabolic risk factors increase immunosuppression however rate fibrosis progression following nash immunosuppression less clear aim incidences steatosis nash fibrosis following nash quantified compared transplanted alcoholic liver disease ald patients methods records nash patients match ald transplant recipients reviewed retrospectively patients without liver biopsies beyond months following excluded results nash patients older less likely male ald patients incidence steatosis nash fibrosis stage increased years groups although steatosis nonalcoholic fatty liver disease activity scores higher fibrosis lower nash compared ald stage year incremental increase rate fibrosis faster first year compared years stage year following rate fibrosis progression years decreased nash compared ald recipients stage year nash etiology associated reduced rate fibrosis progression odds ratio multivariate analysis conclusion despite steatosis inflammation progression fibrosis slower nash compared ald recipients fibrosis progression slows time following immunosuppression approximates pretransplant progression rate year copyright wolters kluwer health inc rights reserved
design mobile electronics power one difficult restrictions overcome current trends indicate continue issue future consumer electronic equipments becoming small portable devices provide users wide range functionality communication music playing battery technology power consumption device limit size weight autonomous lifetime one promising alternative batteries use parasitic energy dissipated movement wearer device power paper designed system included rotary arm extending sole ultimately drove small electrical generator stepped gearbox one way clutch mechanism used transmit torque gearbox allowed additional spin following initial impact step also preventing lockup due rotary inertia gears entire generator system designed fit heel standard running shoe rotary arm compressing heel strike
paper considers study electromagnetic field synchronous generator based three phase induction machine stand includes frequency converter induction motor synchronous generator three phase rectifier active load resistance power protection inclusion industrial electrical network study provides analytical solution one main objectives within theoretical foundations electrical engineering formulated reflect decision making designing new types synchronous generators permanent magnets necessity generators determined development area small scale energy sector due emergence consumer market affordable accessible strong magnets neodymium alloy ndfeb purpose paper obtain analytical solution determination induced electromotive force emf loop placed magnetic field permanent magnet rectangular cross sectional shape relative motion pictures magnetic field generator idling mode transverse longitudinal armature reaction nominal current stator winding presented paper
normothermic vivo liver perfusion nevlp offers potential optimize graft function prior liver transplantation hepatitis virus hcv dependent presence mirna microrna miravirsen locked nucleic acid oligonucleotide sequesters mir inhibits hcv replication aim study assess efficacy delivering miravirsen nevlp inhibit mir function pig model pig livers treated miravirsen nevlp cold storage miravirsen absorption mir sequestration mir target gene derepression determined effect miravirsen treatment hcv infection hepatoma cells also assessed nevlp improved miravirsen uptake versus significant mir sequestration mir target gene derepression seen nevlp vitro data confirmed miravirsen suppression hcv replication established infection prevented hcv infection pretreatment cells analogous pretreatment grafts transplant setting conclusion miravirsen delivery nevlp potential strategy prevent hcv reinfection first large animal study provide proof concept using nevlp modify optimize liver grafts transplantation
recently renovated interest functional dependencies due possibility employing several advanced database operations data cleaning query relaxation record matching forth particular constraints defined canonical functional dependencies relaxed capture inconsistencies real data patterns semantically related data semantic relationships complex data types paper surveyed functional dependencies providing classification criteria motivating examples systematic analysis
procurement use green building materials considered effective methods improving environmental performance real estate products however green procurement still infancy widely adopted real estate industry especially developing countries china barriers hinder real estate developers adopting green procurement merit detailed investigation study examines knowledge real estate developers adopting green procurement barriers encountered real estate development within context chinese real estate business research data used analysis collected questionnaire surveys real estate developers chongqing china hierarchical cluster analysis technique employed conduct comprehensive analysis identifying significant barriers semi structured interview used verify interpret results hierarchical cluster analysis develop suggestions mitigating significant barriers promoting green procurement study reveals real estate developers chongqing china little understanding green procurement green building materials experience adopting green procurement strategy significant barriers contributing include little marketing benefits lack incentive policies research findings provide valuable reference assisting relevant government departments developers take measures towards mitigating green procurement barriers real estate development elsevier rights reserved
whenever interact others judge whenever make judgments compare people internalized standards countless social psychological experiments shown comparative thinking plays ubiquitous role person perception social cognition whole topic social comparison recently aroused interest social neuroscientists begun investigate neural underpinnings present article provides overview neuroimaging electrophysiological studies discuss recent findings consequences social comparison brain processing outcomes highlight role brain reward system moreover analyze relationship brain networks involved social comparisons active forms cognitive perceptual comparison finally discuss potential future questions research neural correlates social comparison could address wolters kluwer health lippincott williams wilkins
shk toxin cysteine rich residue protein ion channel ligand isolated sea anemone stichodactyla helianthus work studied effect inverting side chain stereochemistry individual thr ile residues properties shk protein molecular dynamics simulations used calculate free energy cost inverting side chain stereochemistry individual thr ile residues guided computational results used chemical protein synthesis prepare three shk polypeptide chain analogues containing either allo thr alloile residue three allo thr allo ile containing shk polypeptides able fold defined protein products different folding propensities relative thermal stabilities measured consistent simulation data structures three shk analogue proteins determined quasi racemic ray crystallography similar wild type shk three shk analogues retained ion channel blocking activity
aim unknown whether food allergies greater impact quality life respiratory allergies study compared health related quality life hrqol children allergic wheat grass methods surveyed children wheat allergies median age five grass allergies median age parents child health questionnaires parents chq children chq applied results parents children wheat group recorded significantly lower chq scores impact child allergy general behaviour general health perceptions parental impact emotions time family activities parents children grass allergies values however parents grass group recorded lower scores change health item parents children wheat allergies grass group children parents reported similar scores different questions poorer correlation parents children wheat allergy group conclusion hrqol lower children wheat grass allergies according parental reports consistent perceptions hrqol among parents children grass allergy wheat allergy group
study investigate chronic inflammation autoimmunity might related development chronic myelomonocytic leukemia cmml conducting case control study included cmml subjects diagnosed three hematological departments denmark controls unmatched chronic lymphatic leukemia cll subjects diagnosed one departments subjects history chronic inflammation autoimmune disorders retrieved odds ratios ors calculated cmml subjects cll subjects presented history chronic inflammatory autoimmune conditions significantly associated increased risk cmml adjusted individual levels association statistically significant polymyalgia rheumatica itp values respectively found association cmml smoking status former smokers cmml group
objectives present study aimed determine prevalence etiology erectile dysfunction saudi type diabetic patients patients methods saudi type diabetic male patients aged years recruited total bio available serum testosterone sex hormone binding globulin free testosterone levels measured elisa ibl gmbh germany results subjects hypogonadism total testosterone nmol possible hypogonadism total testosterone nmol similarly using bioavailable levels men overt hypogonadism bioavailable testosterone nmol men possible hypogonadism bioavailable testosterone nmol patients free testosterone nmol hypogonadism bmi waist circumference significantly negatively correlated testosterone levels saudi type diabetic men conclusions testosterone levels frequently low saudi men type diabetes majority patients symptoms hypogonadism prevalence erectile dysfunction diabetic men low testosterone level nmol obesity associated factor low testosterone levels saudi type diabetic patients
accurate fast running stable six group point kinetics model developed applied successfully dynamic simulation operation prismatic core high temperature next generation nuclear plant ngnp reactor model unrestricted size time step could much several seconds accounts doppler broadening fuel graphite temperature reactivity feedbacks includes active neutron source zero power reactor startup efficient robust numerical technique approximates exponential matrix using order accurate pade function discretization error order delta solves coupled nonlinear stiff six groups point kinetics equations model handles reactivity insertions excess prompt critical rho beta bar unrestrictive time step size model results successfully benchmarked using inhour solution step insertion external reactivity simulate transient response ngnp reactor following external reactivity insertion startup model coupled nodes thermal hydraulics model reactor also developed work time step error predicting reactor thermal power similar increasing exponentially similar similar increased time step size respectively present model successfully incorporated melcor nuclear reactor analysis code simulate transient operation high temperature reactor vhtr electricity generation using closed brayton cycle turbomachinery generation hydrogen using sulfur iodine thermo chemical processes elsevier ltd rights reserved
studies investigated effects exercise training sleep physiology well trained athletes investigated changes sleep markers mood state exercise performance well trained cyclists undergoing short term intensified training carbohydrate nutritional intervention thirteen highly trained male cyclists age max min participated two day periods intensified training undergoing high hcho moderate con carbohydrate nutritional intervention training sessions sleep measured night via wristwatch actigraphy mood state questionnaires completed daily performance assessed maximal oxygen uptake percentage sleep time fell intensified training despite increase time bed min sleep efficiency decreased intensified training actual sleep time significantly higher con hcho throughout intensified training mood disturbance increased intensified training higher con hcho performance exercise protocol fell significantly intensified training main findings study days intensified training highly trained cyclists resulted significant progressive declines sleep quality mood state maximal exercise performance
impedance spectroscopy measurements predominantly taken using impedance analyzers based analog auto balancing bridge however bench top analyzers generally complicated bulky expensive thus limiting usage industrial field applications paper presents development compact wideband precision measurement system based digital auto balancing bridge methods digital auto balancing bridge digital lock amplifier analyzed theoretically overall design several key sections including null detector direct digital synthesizer based sampling clock digital control unit introduced detail results show system achieves basic measurement accuracy frequency range mhz advantages versatile measurement capacity fast measurement speed small size low cost make quite suitable industrial field applications demonstrated system practical effective applying determining impedance temperature characteristic motor starter ptc thermistor
modern cryptography increasingly employs random numbers generated physical sources lieu conventional software based pseudorandom numbers primarily owing great demand unpredictable indecipherable cryptographic keys true random numbers information security thus far sole demonstration true random numbers generated thermal noise quantum effects suffers expensive complex equipment paper demonstrate method self powered creation true random numbers using triboelectric technology collect random signals nature random number generator based coupled triboelectric electrostatic induction effects liquid dielectric interface includes elaborately designed triboelectric generator teng irregular grating structure electronic optical device optical electronic device random characteristics raindrops harvested teng consequently transformed converted electronic optical device optical electronic device nonlinear characteristic cooperation mechanical electrical optical signals ensures generator possesses complex nonlinear input output behavior contributes increased randomness random number sequences deduced final electrical signals received optical electronic device using familiar algorithm obtained random number sequences exhibit good statistical characteristics unpredictability unrepeatability study supplies simple practical effective method generate true random numbers widely used cryptographic protocols digital signatures authentication identification information security fields
outdoor industrial scale microalgae cultivation limited several factors among low efficiency overall light energy conversion plays key role mainly due photosaturation photo inhibition high irradiations work aims improving overall photoconversion efficiency microalgal production photobioreactor pbrs exploiting advanced photovoltaic technology semi transparent dye sensitized solar cells module dsc placed irradiated surface thus absorbing part incident light produce electricity transmitted photons used algal cells photosynthesis experiments carried continuous laboratory scale flat panel pbr different constant light intensities day night irradiation regime ascertain performances combined pbr system terms biomass productivity overall photoconversion efficiency compared traditional transparent pbrs results obtained show configuration proposed combining biomass production innovative photovoltaics technology could valuable way improve light energy utilization efficiency microalgal production elsevier ltd rights reserved
desensitization degree emulsion explosives calculated peak pressure explosion shock waves tested water explosive less desensitization degree better compression resistance compression resistance explosive compared analyzed quantificationally desensitization degree influence emulsifier pressure desensitization studied including content category emulsifiers three kinds emulsifiers span compound emulsifier used tests experimental results show content category emulsifiers make great effect oil pressure desensitization desensitization degree reduces emulsifier content increased optimal content emulsifier compression resistance content span reaches desensitization degree becomes minimal value augments somewhat emulsifier content increased say compression resistance becomes highest content span compression resistance decline content span increased compression resistance explosive emulsified compound emulsifier hest among explosives content whole components manufacturing engineering kept invariable
paper problem health monitoring prognosis aircraft gas turbine engines considered using computationally intelligent methodologies two different dynamic neural networks namely nonlinear autoregressive exogenous input neural networks elman neural networks developed designed purpose proposed dynamic neural networks designed capture dynamics two main degradations gas turbine engine namely compressor fouling turbine erosion health status condition engine terms turbine output temperature predicted subject occurrence deteriorations various scenarios consisting fouling erosion separately well combined considered scenario several neural networks trained performance predicting multiple flights ahead tts evaluated finally suitable neural networks achieving best prediction selected using normalized bayesian information criterion model selection simulation results presented demonstrate illustrate effective performance proposed neural network based prediction prognosis strategies
genetic variance associated variations brain morphology cognition behavior disease risk one well studied example common genetic variance associated brain morphology serotonin transporter gene polymorphism within promoter region httlpr serotonin key neurotrophic factor brain development genetically determined variations serotonin activity maturation particular early prenatal development may underlie observed association however intrauterine microenvironment determined child also mother genotype therefore hypothesized maternal httlpr genotype influences child brain development beyond direct inheritance test hypothesis investigated children heterozygous httlpr mothers either homozygous long short allele using mri assessed brain morphology function maternal genotype gray matter density somatosensory cortex found greater children mothers compared children mothers behavioral assessment showed fine motor task performance altered children mothers degree behavioral effect correlated somatosensory cortex density across individuals findings provide initial evidence maternal genotype affect child phenotype beyond effects classical inheritance observation appears explained intrauterine environmental differences differences maternal behavior
trans agency workshop blood brain interface bbi sponsored national heart lung blood institute national cancer institute combat casualty care research program department defense conducted bethesda june workshop structured four sessions blood sciences exosome therapeutics next generation vitro blood brain barrier bbb models bbb delivery targeting first day workshop focused physiology blood neuro vascular unit blood biofluid based molecular markers extracellular vesicles associated brain injury entities employed better evaluate injury states deliver therapeutics second day workshop focused technical advances vitro models bbb manipulations nanoparticle based drug carrier designs goal improving drug delivery central nervous system presentations discussions underscored role bbi brain injury well role bbb limiting factor potential conduit drug delivery brain conclusion meeting participants discussed challenges opportunities confronting bbi translational researchers particular participants recommended using bbi translational research stimulate advances diagnostics well targeted delivery approaches detection therapy brain injury disease
background aims evaluate effect interdisciplinary outpatient geriatrics use cost quality health services fee service ffs environment two networks primary care clinics operated profit provider organization dallas county texas methods senior health network shn provides interdisciplinary primary care patients aged years older health texas provider network htpn provides usual primary care patients ages conducted two year retrospective cohort study fee service medicare beneficiaries visits one networks shn interdisciplinary teams supplemented primary care social services specialized clinics health education compared use cost quality health services reflected paid medicare claims provided eligible patients shn htpn results medicare payments hospital skilled nursing facility home health care services lower shn patients htpn patients respectively shn patients lower likelihood admission hospitals treatment five ambulatory care sensitive conditions aor less likely receive several preventive services total medicare payments two cohorts differ significantly conclusions interdisciplinary outpatient geriatric care ffs setting potential avert hospital admissions ambulatory care sensitive conditions reduce medicare payments hospital skilled nursing facility home health care services
significant occurrence men violence female partners child abuse neglect well documented less clear child safety managed family violence research mothers issue salient isafe new zealand based internet intervention study testing improvement safety decisions mental health outcomes women experiencing intimate partner violence article discusses legislative professional ethical considerations contribute development child safety protocols discusses development isafe protocol hypothetical scenarios application isafe protocol used illuminate issues provide basis future discussion
sequential estimation delay doppler parameters sub nyquist radars analog information conversion aic systems received wide attention recently however estimation methods reported aic dependent poor performance grid targets paper develops general estimation scheme sense applicable aics regardless whether targets grids proposed scheme estimates delay doppler parameters sequentially delay estimation formulated beamspace direction arrival problem doppler estimation translated line spectrum estimation problem well known spatial temporal spectrum estimation techniques used provide efficient high resolution estimates delay doppler parameters addition sufficient conditions aic guarantee successful estimation grid targets provided existing conditions mostly related grid targets theoretical analyses numerical experiments show effectiveness correctness proposed scheme
biologically active compounds isolated medicinal herbs center interest researchers investigate possible effects mechanisms exert action current study investigated antiproliferative effect mechanism action deoxypodophyllotoxin semi synthetic compound derived extract chinese herbal medicine dysosma versipellis hance cheng ying berberidaceae study conducted mcf mda breast cancer cell lines antiproliferative effect deoxypodophyllotoxin assessed cell counting kit assay flow cytometry annexin mitochondrial membrane potential caspase inhibition assays western blot analysis performed detect explore assess antiproliferative effect deoxypodophyllotoxin data revealed deoxypodophyllotoxin treatment resulted dose responsive inhibition mcf mda cell growth low respectively disrupted cytoskeleton induced significant cell cycle arrest phase cell lines interference cell cycle regulatory proteins cyclin cdcc cdk mcf cells cell cycle inhibition associated apoptosis caspase dependent involved elevation bax protein cleavage parp finding along disruption mitochondrial membrane potential confirmed involvement intrinsic pathway deoxypodophyllotoxin induced apoptosis mcf cells however mda cells deoxypodophyllotoxin cytostatic significantly suppresses proliferation cell cycle arrest phase without apoptotic induction activity deoxypodophyllotoxin could expected spare normal tissues toxic side effects
prospective study aimed investigate macular structural characteristics children syndrome compared healthy children two groups children aged years enrolled children syndrome syndrome group age matched healthy children full term birth control group eligible patients visual acuity better gestational age birth parts per thousand yen weeks fourier domain optical coherence tomography used imaging macular retinal structure retinal volume scans centered macula obtained central subfield thickness cst thickness inner outer retinal layer regions analyzed using instrument segmentation software analysis data provided right eye since significant difference right left eyes either syndrome control groups children syndrome group generally identifiable retinal structure cst full retina inner outer retinal layers significantly greater syndrome group control group independent test despite significantly thicker macula right eyes patients syndrome macular thickness outside normal range visual acuity syndrome group directly correlated increased cst average cst syndrome group greater control group suggesting abnormal macular development children syndrome
objective summarize evidence regarding effectiveness dose response characteristics pre operative exercise programmes post operative physical function following total knee arthroplasty data sources cinahl cochrane library pubmed sportdiscus embase study selection randomized controlled trials eligible provided full description physiological stress mode frequency intensity duration data extraction data extraction evaluation performed one reviewer methodological quality selected studies assessed using physiotherapy evidence database scale data synthesis twelve candidate studies identified papers satisfied inclusion criteria studies evaluated effect resistance training trial investigated proprioceptive training latter study elicited significantly enhanced post operative gains function indices standing balance overall stability index hedges anteroposterior stability index hedges weeks post surgery results meta analysis based findings studies showed compared controls prehabilitative exercise involving resistance training offered additional gains isometric quadriceps muscle strength weeks post operatively conclusion despite potential efficacy exercise based conditioning review highlights scarcity robust dose response evidence guide formulation total knee arthroplasty prehabilitation effectively
paper presents preliminary results application two kinect cameras system two wheeled indoor mobile robot line optimal path planning execution approach robot makes use depth information delivered vision system accurately model surrounding environment image processing techniques addition genetic algorithm implemented generate collision free optimal path linking initial configuration mobile robot source final configuration target piecewise cubic hermite interpolating polynomial used smooth generated optimal path finally adaptive fuzzy logic controller designed keep track mobile robot desired smoothed path transmitting appropriate right left velocities using wireless communication parallel sensor fusion odometry sensors kinect sensors used estimate current position orientation robot using kalman filter validation proposed solution carried using differentially driven mobile robot robuter successfully achieve safe motion without colliding obstacles indoor environment elsevier rights reserved
several longitudinal studies meta analytic reviews demonstrated exposure violent media linked aggression time however evidence effective interventions reduce use violent media promote critical viewing skills limited current study examined efficacy intervention designed reduce use media violence aggression adolescence covering total period months sample graders germany girls assigned two conditions week intervention intervention control group measures exposure media violence aggressive behavior obtained months prior intervention months post intervention intervention group showed significantly larger decrease use violent media control group participants intervention group also scored significantly lower self reported aggressive behavior physical aggression relational aggression control group effect limited high levels initial aggression effect mediated intervention induced decrease normative acceptance aggression gender differences program efficacy found results show week school based intervention produce changes use media violence aggressive norms behaviors sustained several months
machine design perspective field study faculty mechanical engineering fme university west bohemia regards demand graduates field days main issue higher education czech republic related machine design lack opportunities students machine design acquire practical knowledge experience field problem engineering companies offer work experience individual students try hire graduation engineering companies motivated enough contribute machine design teaching process providing knowledge experience majority students going change soon universities provide real applications students instead currently enough opportunities students acquire practical knowledge field studies required amount work experience engineering students czech republic one week insufficient comparison german system internship semesters mandatory part studying fachhochschule university applied sciences necessary provide practical information real applications class compensate lack practical experience fme concerned matter launched project enhancement teaching process new concept electronic learning materials machine design developed part project learning materials developed academics cooperation local engineering companies provide students academics fme real design projects reworked learning purposes machine design teaching process complicated due complexity mechanical design process particularities need considered creating learning materials describing mechanical design process design process described also production processes project schedules economic aspects design project legislative technical standards regulations described well parts mechanical design process affect important describe context mechanical design process show interconnection electronic form learning materials selected offers many advantages standard printed form main reason selecting electronic form learning materials ability work computer aided engineering cae models three dimensional cae models replaced drawing boards every engineering company several years ago thus important include cae models machine design teaching process thanks technology exporting cae models standard portable document format pdf possible modify cae models learning purposes use learning tool cae models enhanced large amount information regarding design project manufacturing processes materials component functions supplemented technical drawings illustrated project descriptions information learning material converted single pdf file every student access anywhere anytime versatility interactivity biggest benefits new electronic learning materials new electronic learning materials used explaining new subject matter show application basis students assignments individual work teamwork dissertations sample electronic learning materials produced made available students courseware university west bohemia paper intends present learning materials describe form structure content benefits academics students machine design
karst area indonesia consists total area protected pacitan part thousand mountains gunung sewu javanese language karst area located southern coastal java island gunung sewu karst area ranges west yogyakarta special province east east java province water scarcity one issues pacitan due porous texture karst underground precipitation trickles immediately extensive system sinkholes caves thus surface water rivers brooks springs found area especially dry season water supply little lakes called telaga depleted three sub districts pacitan include gunung sewu karst area donorojo punung pringkuku suffer water shortage especially dry season local communities need walk kilometers order take water domestic use however state owned water company perusahaan daerah air minum pdam developed since pacitan contributes water supply areas covered three kecamatan sub districts building ipa currently developing cover rest area utilizing big water sources pdam ministry public work support water treatment installation instalasi pengolahan air ipa especially three sub districts furthermore adaptive capacity developed local community karst area pacitan planting cultivars resistant drought cassava maize soybean groundnut multi cropping cultivars planting rainwater harvesting artificial aquifer authors published elsevier
background computed protein multiple sequence alignment coreness column fraction substitutions called core columns gold standard reference alignment proteins benchmark suites protein reference alignments core columns reference alignment confidently labeled correct usually due residues column sufficiently close spatial superposition known three dimensional structures proteins typically accuracy protein multiple sequence alignment computed benchmark measured respect core columns reference alignment computing alignment practice however reference alignment known coreness columns predicted results develop first time predictor column coreness protein multiple sequence alignments allows predict columns computed alignment core hence better estimate alignment accuracy approach predicting coreness similar nearest neighbor classification machine learning except transform nearest neighbor distances coreness prediction via regression function learn appropriate distance function new optimization formulation solves large scale linear programming problem apply coreness predictor parameter advising task choosing parameter values aligner scoring function obtain accurate alignment specific set sequences show task predictor strongly outperforms column confidence estimators literature affords substantial boost alignment accuracy
improved controller energy management system power split hybrid electric vehicle hev developed objectives minimizing fuel consumption improving drivability considering specific application vehicles plying scheduled trips public transport paper assumes controller privileged priori knowledge estimated total tractive energy requirement duration journey comparison recently introduced constant highefficiency region cher based controller paper demonstrates reductions fuel consumption achieved certain driving cycles limiting internal combustionengine ice operation dynamically varying high efficiency region adopting state charge soc swing control battery energy storage frequency engine therefore directly decided size energy storage allowable swing soc tractive energy required performances cher dynamic high efficiency region dher controllers compared simulations existing controller commercial vehicle results reveal dher controller outperforms two controllers terms fuel consumption highway style driving scenarios therefore minimize fuel consumption improving drivability driving scenarios paper proposes combine cher controller dher controller best features controllers utilized
traditional examination teacher choose group organization examination examination papers correct determine results therefore many factors standardization degree difficulty degree rationality evaluation easily influenced subjective factors traditional examination group organization examination paper evaluation performance analysis test paper retained heavy workload big task addition traditional test feedback ability weak embodied exam paper choose optional gender big analysis results stay average pass surface level existing online examination system achieve paperless examination volume group result analysis basic traditional way paper mainly discusses key technology development intelligent test system focusing generating test paper algorithm design achievement data mining algorithm analysis design improve system test paper quality performance analysis teaching learning future provide detailed decision analysis
trabecular bone score tbs gray level texture measure derived lumbar spine dual energy ray absorptiometry dxa images predicts fractures independent bone mineral density bmd increased abdominal soft tissue individuals elevated body mass index bmi absorbs rays image acquisition bmd measurement must accommodated tbs algorithm aimed determine relationship bmi tbs varied major manufacturers densitometers different densitometers accommodate soft tissues differently identified women men participants canadian multicentre osteoporosis study aged lumbar spine dxa scans acquired lunar centers hologic centers densitometers year follow tbs calculated tbs insight software version significant negative correlation tbs bmi observed tbs measurements performed hologic densitometers men pearson women pearson significant correlations seen tbs measured lunar densitometers pearson men pearson women age adjusted linear regression models confirmed significant interactions bmi densitometer manufacturer men women contrast comparable positive correlations observed bmd bmi hologic lunar densitometers men women conclusion bmi significantly affects tbs values men women measured hologic lunar densitometers finding implications clinical research applications tbs especially tbs measured sequentially dxa densitometers different manufacturers results different machines pooled analysis
purpose reviewunderstanding factors lead asthma development early life essential developing strategies aimed primary secondary prevention recent findingsthis article review current evidence addressing development early life allergic sensitization relation microbes gut airway microbiome wheezing illnesses particularly viral remain significant risk factor asthma inception however bacterial pathogens recently emerged additional important contributor asthma risk either alone cofactors viral infections combined influence interaction early life viral wheezing aeroallergen sensitization important allergic sensitization preceding onset viral wheeze lastly review recent data longitudinal studies regarding development irreversible airway obstruction impact natural history asthma summarythe development asthma remains complex incompletely understood interplay genetic predisposition environmental exposures including allergens microbes interventions aimed risk factors preschool years may prevent longitudinal course asthma progression irreversible airway obstruction
objectives review pathophysiology morbidities therapeutic options psoriasis psoriatic arthritis rheumatoid arthritis order understand similarities differences treatment paradigms management disease new targets individualized therapeutic decisions also identified aim improving therapeutic outcome reducing toxicity search strategy using pubmed database searched literature published using combinations key words psoriasis psoriatic arthritis rheumatoid arthritis pathogenesis immunomodulation treatment inclusion exclusion criteria non systematic review formal inclusion exclusion criteria data extraction abstracts identified search screened relevance articles considered appropriate evaluated references within selected articles also screened information extracted articles inclusion report data synthesis formal data synthesis articles reviewed summarized according disease area psoriasis psoriatic arthritis rheumatoid arthritis headline results pathophysiology psoriasis psoriatic arthritis rheumatoid arthritis involves chronic inflammation mediated pro inflammatory cytokines dysfunction integrated signaling pathways affecting different constituents immune system result varying clinical features three diseases morbidities including cardiovascular disease malignancies non alcoholic fatty liver disease increased increased understanding immunopathogenesis allowed development targeted treatments however despite variety potentially predictive genetic protein cellular biomarkers still significant unmet need three inflammatory disorders authors published elsevier journals inc
digital control switching power converters proposed researched recent years however one problems arise circuits quantization induced limit cycle oscillations generally considered undesirable work investigate addition new control terms feedback loop system order actively prevent limit cycles occurring firstly addition sinusoidal signal considered complicated signal focuses interrupting system switches duty cycle levels presented methods effective removing limit cycle oscillations arise system copyright john wiley sons ltd
paper proposes fault location algorithm ultra high voltage untransposed parallel transmission lines use voltages currents local end proposed algorithm uses voltage equation faulted phase faulted line equation contains fault distance fault resistance fault current obtain fault current kirchhoff voltage law applied loops three phases consisting faulted line adjacent parallel line fault current represented terms fault distance inserting fault current voltage equation results equation contains two parameters fault distance fault resistance fault distance estimated solving equation test results indicated algorithm accurately estimates fault distance regardless fault resistance mutual coupling effects
objectives determine pressure flow study pfs parameters including flow index calculated dividing average urethral flow maximal urethral flow increase accuracy urodynamic studies diagnosis overactive bladder oab study design retrospective study evaluate medical history urodynamic examination results female patients diagnosed lower urinary tract symptoms luts january december patients stratified four groups depending type luts oab stress urinary incontinence sui mixed urinary incontinence predominant sui symptoms mui sui mixed urinary incontinence predominant oab symptoms mui oab results oab diagnosed patients sui diagnosed patients mui oab diagnosed patients mui sui diagnosed patients calculated using free uroflowmetry free significantly lower oab group compared groups analysis revealed difference free sui mui sui mui oab groups significant differences found study groups free uroflowmetric parameters including maximal urethral flow average urethral flow micturition volume similar differences found pfs parameters conclusions decrease urethral lumen due presence transurethral catheter patients oab contrast women sui mui found influence calculated using free uroflowmetry pfs may serve important objective diagnostic tool oab calculated free uroflowmetry parameters assessing patients luts elsevier ireland ltd rights reserved
statistical properties light waves reflected one dimensional disordered optical medium well studied however studies focused situation mean refractive index optical medium matched outside medium considering gaussian color noise refractive index medium exponential spatial correlation decay length incident wave vector shown smaller correlation length limit mean reflection coefficientand std sigma value follow relation sigma proportional tol however refractive index sample medium different outside medium reflection statistics may interesting features well studied understood studied reflection statistics weakly disordered optical medium mean background refractive index different outside medium equal see effect mismatching value reflection statistics mismatched case results show mean reflection coefficientfollows form similar matched refractive index case proportional tolc linear increased shift due uniform background reflection slab however sigma shown sigma proportional different matched case change std attributed interference mismatched crerated edge mediated multiple scattering coupled random scattering applications light scattering random layered media biological cells discussed
haemophilia congenital bleeding disorder characterised recurrent haemorrhages major joints haemophilic arthropathy well established outcome recurrent joint bleeding however clear multiple factors determine extent severity occurrence sought identify genetic factors related abnormalities range motion rom knees ankles elbows cohort children adolescents haemophilia treated primarily regular prophylaxis using data haemophilia growth development study examined associations genetic markers rom scores measured six month intervals seven years first step ordered logistic regression models fit joint separately subset snp markers showing significant effects right left sides least two joints included full model fit using multivariate generalised linear mixed model assuming ordinal response models contained rom scores obtained visits twenty five markers analysed full model showed either increased decreased risk rom abnormalities level several genes identified either first second stage analysis associated arthritis variety large studies results support likelihood risk haemophilic arthropathy associated genetic factors identification holds promise advancing individualisation treatment
many attempts made manufacture multi contact nerve cuff electrodes safe robust reliable long term neuroprosthetic applications protocol describes fabrication technique modified cylindrical nerve cuff electrode meet criteria minimum computer aided design manufacturing cad cam skills necessary consistently produce cuffs high precision contact placement various cuff sizes precision spatially distributing contacts ability retain predefined geometry accomplished design two criteria essential optimize cuff interface selective recording stimulation presented design also maximizes flexibility longitudinal direction maintaining sufficient rigidity transverse direction reshape nerve using materials different elasticities expansion cuff cross sectional area result increasing pressure inside cuff observed test demonstrates flexibility cuff response nerve swelling post implant stability contacts interface recording quality also examined contacts impedance signal noise ratio metrics chronically implanted cuff months observed omega respectively
paper presents diversity integrated circuit digital satellite radio sdars ghz contains circuit enables fast adaptive processing three antenna signals maximum ratio combining fast fading scenario front end diversity system integrated using cmos technology phase three input paths adjusted quantized steps degrees degrees degrees input signal one path suffers fading single path completely turned reducing power consumption diversity evaluated means laboratory measurements well tests antenna signals real fading scenarios processed using presented results show typical improvement radio reception factor compared conventional reception system
examined extent emerging adults engage different behaviors instagram popular social networking site gain attention validation others via likes also examined individual differences frequency like seeking behavior motives instagram use mediators relationships participants replication study recruited via online crowdsourcing portal complete survey results demonstrated predicted participants engaged assortment different like seeking behaviors two factor solution emerged like seeking behavior separated whether normative common accepted using filters hashtags deceptive buying likes changing one appearance photos using software deceptive like seeking predicted stronger narcissism weaker sense peer belonging whereas normative like seeking predicted stronger narcissism stronger sense peer belonging consistent hypotheses significant mediators relation narcissism deceptive like seeking included motives use instagram increase popularity showcase creativity results help identify young people susceptible engaging deceptive potentially harmful acts gain attention validation instagram elsevier ltd rights reserved
background thyroid hormones essential maintenance pregnancy deficiency maternal thyroid hormones associated early pregnancy losses aim study systematic investigation influence mifepristone expression thyroid hormone receptor thr isoforms thr alpha thr alpha thr beta thr beta protein mrna level methods samples placental tissue obtained patients mifepristone induced termination pregnancy mechanical induced termination normal pregnancy week pregnancy expression thr alpha thr alpha thr beta thr beta analysed protein level immunohistochemistry mrna level real time pcr tagman influence progesterone thr gene expression analysed trophoblast tumour cell line bewo real time pcr tagman results nuclear expression thr alpha thr alpha thr beta downregulated protein level mifepristone treated villous trophoblast tissue decidual tissue found significant downregulation thr alpha mifepristone treated tissue mrna level also found significantly reduced expression thra significant downregulation thrb placental tissue gene thra encodes isoform thr alpha gene thrb encodes isoform thrp majority cells expressing thyroid hormone receptors decidua decidual stromal cells addition vitro experiments trophoblast tumour cells showed progesterone significantly induced thra thrb expression conclusions termination pregnancy mifepristone leads downregulation thr alpha thr alpha thr beta villous trophoblasts addition decreased expression thra placental tissue decreased expression thr alpha induced could also found decidua therefore inhibition progesterone receptor may responsible downregulation assumption supported finding stimulation progesterone receptor progesterone upregulated thra trophoblast cells vitro elsevier ireland ltd rights reserved
sentiments online word mouth wom often controversial since individuals different preferences toward products past studies focused online wom effects measuring wom volume valence however studies investigated entropy review text sentiment influences relationship online wom product sales wom valence volume usually provided aggregated level consumers often enough information make decision case reading online review text become important process consumers make purchasing decisions however consumers encounter many positive review texts may doubt credibility online wom thus analyzed entropy review text sentiments conducting text mining techniques classified review text sentiment positive negative neutral categories created entropy variable high level entropy review texts indicates sentiment review texts equally distributed biased towards positive negative sentiment estimated research model entropy variable panel dataset movies half year period results suggest entropy level review texts positive moderating impact relationship wom valence volume movie box office sales findings imply deleting negative reviews enhance product sales may help online retailers related parties elsevier rights reserved
objective clarify effects mental health physical function association colonoscopy related pain methods mental health physical function evaluated using japanese version health survey questionnaire poor physical status defined physical component summary pcs poor mental status mental component summary mcs insignificant pain vas background colonoscopic findings compared patients significant insignificant pain patients study evaluated consecutive japanese patients positive fecal occult blood tests underwent total colonoscopy results patients significant insignificant colonoscopy related pain multiple logistic regression analysis showed mcs odds ratio confidence interval pcs seconds reach cecum independent risk factors colonoscopy related pain conclusion mental health physical function important determinants colonoscopy related pain evaluating mental health physical function patients prior colonoscopy may effectively predict degree colonoscopy related pain
urinary dysfunction common non motor feature parkinson disease might secondary neurodegeneration involving cortical subcortical brain areas possible link cognitive deficits never examined frontal cortex impairment still completely understood present study patients underwent comprehensive motor cognitive non motor assessment shown patients reported needed specific urological treatment patients reported performed worse global cognition panda visuo constructive functions cerad praxis figure test instrumental activities daily living functions iadl patients without group medication performed worse global cognition panda visuo constructive functions cerad praxis cerad praxis recall group without medication independent anticholinergic treatment effect findings suggest association cognitive impairment independent symptomatic treatment
negative feedback technique employing high gain operational amplifier amp one important techniques analog circuit design however high gain amp difficult realize scaled technology due decrease intrinsic gain paper high gain amp using common gate topology high power efficiency proposed achieve high gain large output impedance required input transistors drain conductance decreases output impedance conventional topology folded cascode topology complementary input bias current output side transistors separated bias current input transistors hand proposed circuit suppress degradation output impedance inserting common gate topology input output side architecture separates bias current input transistors output side hence effect drain conductance input transistors reduced result proposed circuit increase gain compared folded cascode topology complementary input cmos process moreover power consumption reduced input nmos pmos share bias current according simulation results power consumption proposed circuit gain bandwidth product gbw improved approximately noise also reduced comparison conventional topology
objectives several studies cited potential association testosterone deficiency risk falls among community dwelling older men evidence association conflicting depressive symptoms occasionally accompany testosterone deficiency often neglected associated symptoms may actually provoke falls independent jointly testosterone deficiency examined association testosterone levels depressive symptoms falls assessed joint effect testosterone levels depressive symptoms falls among older men design setting participants data cross sectional study obtained men aged years participated health check ups conducted japanese municipalities salivary testosterone levels measured using enzyme linked immunosorbent assay depressive symptoms assessed via short form center epidemiologic studies depression scale main outcome measures self reported fall month period results among total participants analyzed median age years reported fall comparison percentile levels lower levels logistic regression model restricted cubic splines showed lower levels associated increased likelihood suffering fall adjustment sociodemographic characteristics comorbidities mobility function example percentile associated fall adjusted odds ratio confidence interval depressive symptoms also strongly associated fall adjusted noted apparent interaction depressive symptoms falls suggesting joint effect testosterone deficiency depressive symptoms falls multiplicative indeed compared combination percentile values depressive symptoms adjusted fall combination involving percentile depressive symptoms fold conclusions findings indicated relatively low testosterone levels presence depressive symptoms independently associated falls among older men causality associations confirmed future prospective studies published elsevier inc behalf american medical directors association inc
effective project coordination management time cost scheduling public funded construction projects receive considerable focus academics politicians construction industry opposing points view study objective therefore investigate process time cost scheduling different project stages relationships critical factors affecting project schedules applied data collection based semi structured interviews questionnaire survey publicly agency employed project managers property managers multiple research approach thus utilized mix two dataset findings demonstrate project complications execution stage associated lack project requirements design optimistic project deadline budget initial project stages moreover relationship found presence experienced consultants achievement project success throughout project phases particular vital
large amount methane releasing residual coal surrounding pressure relieved gas bearing strata may accumulate longwall gob gas bearing coal seam increasingly exploited major source coalbed methane cbm development coal mining areas meanwhile gob methane emits working space along air leakage flow may impair safety productivity underground coal mines thus gob gas drainage great significance cbm development control gob gas emission currently exist two major technologies gob gas drainage gob gas ventholes ggvs drainage underground drainage high level suction tunnels high located boreholes buried pipes upper corner practical engineering applications ggvs greater advantage traditional underground drainage extraction flux gob gas control gob gas emission theoretical mechanism ggvs yet revealed previous studies consequently characteristics gob gas flow ggvs drainage needs research paper numerical simulation gas flow gob gas reservoirs situ assessment ggvs drainage carried investigate mechanism control gob gas flow ggvs drainage firstly based fluid mechanics porous media mathematical model gob gas transport developed gas pressure distribution gas flow patterns methane concentration distribution gob conditions drainage measures drainage buried pipe upper corner ggvs different locations discussed conducting numerical simulation respectively addition influence distance ggv return airway gob methane flow strong control scope ggvs analyzed detail found ggvs flow interception effect gas deep zone gob flow reversal effect gas gob close longwall face accounts ggvs drainage advantage underground drainage ggvs applied drain gas deep zone gob massively control gob gas migration effectively top choice extraction gob gas control gob gas emission finally ggvs drainage underground drainage adopted extract gob gas east working face weijiadi coal mine comparison extracted emitted volume gob gas two different technologies shows ggv drain gob gas greater flux better control gob gas emission validated prediction numerical stimulation elsevier rights reserved
objectives conduct systematic review effectiveness barriers facilitators initial teacher training promote health well schools design systematic review literature method total bibliographic databases searched including medline embase social science citation index studies included reported research processes outcomes initial pre service teacher training promote health results total studies met inclusion criteria mainly australia twelve studies assessed outcomes commonly using uncontrolled assessment designs sixteen studies evaluated processes training training diverse terms content format health topics studies demonstrated short term increases trainee teachers factual knowledge health issues general increase teachers confidence teach health identify help children specific health issues increase teachers positive beliefs role promoting children health none studies assessed changes pupil outcomes training generally considered acceptable adequate trainee teachers however trainees felt still lacked knowledge confidence address sensitive health issues entering teaching practice conclusion systematic review identified evidence effectiveness teacher training health highlighted factors facilitate inhibit effective training evaluation using controlled trial designs long term follow teacher pupil outcomes may enable teachers effectively address health education needs school pupils
although robust literature describes intergenerational effects traumatic experiences various populations evidence specific refugee families scattered contains wide variations approaches examining intergenerational trauma using preferred reporting items systematic reviews meta analyses prisma criteria purpose systematic review describe methodologies findings peer reviewed literature regarding intergenerational trauma refugee families aimed critically examine existing literature characterizes refugee trauma long term effects descendants psychosocial processes transmission order provide recommendations future research results highlight populations upon current evidence based conceptualizations refugee trauma effects parental trauma transmission descendants health well mechanisms transmission underlying meanings attributed parental trauma refugee families greater methodological rigor consistency future evidence based research needed inform supportive systems promote health well refugees descendants
background day center case management home care components local senior health agency used different screening forms assessing clients fall risk common instrument easily administered components part routine practice would helpful systematically identifying elders risk falling developing common screening instrument would useful senior health agencies well purpose gather information content features useful fall screening based needs individual geriatric care workers component local senior health agency methods semistructured interview used gather feedback geriatric care workers needed universal fall risk screening results two major themes emerged factors relevant assessing fall risk factors affect utility fall risk screening procedure theme categories fall history physical function impairments medications mental psychological status home environment theme categories methods gathering information fall risk assessment features useful fall risk assessment form actions taken response fall risk assessment fall risk categories identified interviews combined categories identified literature health status fear falling produce universal form use different agency components discussion integrating fall risk categories universal form improves completeness form used different agency components however increase utility fall risk screening service plans integrated screening procedure need developed according specific agency structures step procedure proposed improve effectiveness fall risk screening initial screening outreach worker using quick question assessment follow comprehensive fall risk assessment receiving services day center case management home care action presented item basis question response comprehensive form conclusions designing fall risk screening procedure integrating fall risk factors single comprehensive form may ideal strategy environment person gathers information actions required respond information gathered also considered basis results qualitative study presented step procedure supporting forms address considerations
water quality issues suburban watersheds greatly attributed rapid urban development stormwater runoff pollution contribution agricultural practices still significant often overlooked objective study assess water quality impacts managing agricultural urban lands suburban watershed neshanic river watershed headwater watershed mixed land uses located hunterdon county new jersey usa agricultural lands urban lands represents typical natural resource conditions water quality problems suburban new jersey usa soil water assessment tool swat used evaluate potential water quality impacts agricultural urban land use management practices suburban watershed four management scenarios baseline best case worst case developed interviews meetings farmers natural resource conservation professionals represent achievable ideal worst operation conditions urban agricultural lands watershed specific water quality parameters assessed soil total nitrogen phosphorus losses modeling results demonstrate mismanagement urban agricultural lands suburban watersheds worst case could significantly exacerbate existing water quality problems till row crops best case necessarily improve water quality agriculture still primary source water pollution attention continuously paid implement agricultural bmps reduce agricultural nonpoint source pollution suburban watersheds
case study trialled introduction student response system top hat third year engineering fluid mechanics course improve student engagement motivation cognition recognised potential benefits student response systems srss fully realised time must allocated student engagement active learning components course order allow sufficient time fully engage srss classroom activities traditional lectures revised classroom format flipped paper presents initial case study results focusing use srss overall new flipped lecture srs teaching format demonstrated substantial increase level student engagement motivation active learning attendance compared previous cohorts however increased levels engagement appear reflect large increase students individual grades
preclinical imaging brain activity requires use anesthesia study compared effects two widely used anesthetics inhaled isoflurane ketamine xylazine cocktail cerebral blood flow metabolism rat model parkinson disease dopa induced dyskinesia specific tracers used estimate regional cerebral blood flow rcbf iodoantipyrine regional cerebral metabolic rate rcmr deoxyglucose highly sensitive autoradiographic method two types anesthetics quite distinct effects dopa induced changes rcbf rcmr isoflurane affect either absolute rcbf values increases rcbf basal ganglia dopa administration contrary rats anesthetized ketamine xylazine showed lower absolute rcbf values rcbf increases induced dopa masked developed novel improved model calculate rcmr found lower metabolic activities rats anesthetized isoflurane compared animals anesthetized ketamine xylazine anesthetics prevented changes rcmr upon dopa administration pharmacological challenges isoflurane anesthetized rats indicated drugs mimicking actions ketamine xylazine adrenergic glutamate receptors reproduced distinct effects injectable anesthetics rcbf rcmr results highlight importance anesthesia studies cerebral flow metabolism provide novel insights mechanisms mediating abnormal neurovascular responses dopa parkinson disease elsevier inc rights reserved
background kinesio taping widely used clinical practice however unknown whether type tape effective placebo taping patients chronic lower back pain objective compare effectiveness kinesio taping patients chronic non specific low back pain placebo tape control group method arm randomized controlled trial blinded assessor sixty patients chronic non specific low back pain randomized one three groups kinesio taping group micropore placebo group control group patients allocated kinesio taping group placebo group used different types tape period hours control group receive intervention outcomes measured pain intensity measured point numerical rating scale disability measured item roland morris disability questionnaire blinded assessor measured outcomes baseline hours days randomization results hours statistically significant difference kinesio taping group versus control group mean group difference points difference compared placebo group mean group difference points outcomes differences observed conclusions kinesio taping better placebo micropore patients chronic low back pain
optical logic gates important building blocks conducting optical digital analog signal processing computing several uses high speed communication system last years various non linear properties semiconductor optical amplifier utilized realization optical logic gates exploiting different type optical modulations connection optical phase encoding technique drew attention last years shows higher receiver sensitivity extended tolerance limit long haul fiber transmission systems communication authors proposed alternative approach conducting optical logic gates phase encoded inputs exploitation four wave mixing fwm property semiconductor optical amplifier soa elsevier gmbh rights reserved
introduction smoking known risk factor fracture healing postoperative complications however evidence upon association bone healing smoking investigated retrospective studies laboratory based animal studies meta analysis evaluated clinical efficacy preoperative smoking cessation healing fractures postoperative complications evidence acquisition medline embase cnki cochrane database retrieved identifying relevant study four studies including three randomized controlled clinical trials rcts one non randomized concurrent controlled trial nrccts involving total patients included evidence synthesis patients preoperative smoking cessation risk overall postoperative complications lower risk ratio confidence interval compared patient without smoking cessation preoperative smoking cessation reduced risk wound related complications recurrent surgery additional complications one nrcct showed risks fracture non union osteomyelitis patients preoperative smoking cessation reduced conclusion study supports role preoperative smoking cessation orthopaedic surgery outcomes
acute transverse myelitis atm progressive autoimmune disease inflammatory cell infiltrates spinal cord thyroid hormone level associated oxidative antioxidant status variations oxidative stress antioxidant levels related pathogenesis autoimmune inflammatory diseases study aimed investigate possible correlation atm levels thyroid stimulating hormone tsh free thyroxine free triiodothyronine measured serum concentrations tsh individuals including atm patients multiple sclerosis patients healthy controls findings show atm patients lower levels tsh higher levels compared healthy controls whether male female moreover levels tsh patients atm inversely correlated disease severity measured expanded disability status scale variations level may represent oxidative status surrogate biomarkers incidence severity atm neuroreport copyright wolters kluwer health inc rights reserved
hypervisors operating systems support vertical elasticity techniques memory ballooning dynamically assign memory virtual machines vms however current cloud management platforms cmps opennebula openstack currently support dynamic vertical elasticity paper describes system integrates cmp provide automatic vertical elasticity adapt memory size vms current memory consumption featuring live migration prevent overload scenarios without downtime vms enables enhanced per host consolidation ratio maintaining quality service vms since memory dynamically increased necessary feasibility development assessed via two case studies based opennebula featuring horizontal vertical elastic virtual clusters production grid infrastructure elastic multi tenant vms run docker containers coupled live migration techniques results show memory oversubscription integrated cmps deliver automatic memory management without severely impacting performance vms results memory management framework premises clouds features live migration safely enable transient oversubscription physical resources cmp elsevier rights reserved
introduction provide effective form birth control men may choose reversible permanent form contraception vasectomy presently offered permanent option male contraception patients interested vasectomy reversal temporary birth control option pnrpose paper determine vasectomy offered selected couples temporary form contraception circumstances materials methods aliterature review conducted determine available reversible contraceptive options risks failure rates contraindications risks success rates vasectomy vasectomy reversal results reversible contraceptives include hormonally based methods women non hormonal anatomic barrier devices spermatocidal agents hormone based therapies may contraindicated women cardiovascular disease hypertension cancers non hormonal contraceptives generally less effective may unacceptable couples due higher failure rates difficulty use lack acceptance vasectomy vasectomy reversal low risk procedures reversal may performed high degree success particularly short obstructive interval patency performed years following vasectomy conclusion vasectomy considered permanent form sterilization couples select couples unable unwilling use forms birth control would benefit informed discussion using vasectomy reversible form contraception
article suggests new method errors evaluation several common mode signals differential difference operational amplifiers ddas based theory autonomous multiport circuit errors dda main connection circuits described feeding special current autonomous parameter classical equivalent circuit dda parameter connected highimpedance node dda depends level common mode components inputs input differential stages also parameters spread elements paper shows ddas common mode rejection ratio cmrr significantly worsens comparison classical amp parametric circuitry methods cmrr increase ddas based inherent compensation parasitic impedances considered
ankylosing spondylitis often involves heart aortic mitral regurgitation conduction disorder cardiomyopathy present year old male patient ankylosing spondylitis severe aortic regurgitation mild mitral stenosis conduction disturbance left bundle branch block identified using multimodal images
interconnected electricity networks supergrids considered possible solution tackle challenges associated near far future supply electricity include limited reducing green house gas emissions reliance non renewable fossil fuels supergrids help tackle challenges example providing reliable interconnection platform wider application development renewable technologies however range risks uncertainties associated selecting appropriate interconnections heretofore hindrance developing interconnections therefore risk based framework rbf addresses risks uncertainties could encourage wider uptake supergrids paper presents first time robust framework rbf comprises four stages initial screening selecting candidate countries risk identification risk semi quantification risk quantification stage uncertainties associated identified risks quantified using cost risk model uncertainty based whole life appraisal approach usefulness approach demonstrated using case study showed greatest cost risks associated regulatory framework changes energy policy desirable interconnection option identified france elsevier ltd rights reserved
objective aimed investigate clinical setting effects different classes psychotropic drugs cardiac electrophysiological measures linked increased risk sudden cardiac death methods conducted cross sectional study population psychiatric inpatients studying effects various psychotropic drugs peak end tpte interval dispersion interval results methadone use showed strong association tpte prolongation odds ratio confidence interval effect independent action interval mood stabilisers showed significant effects ventricular repolarisation lithium associated tpte prolongation valproic acid tpte reduction among antipsychotics clozapine increased tpte piperazine phenothiazines increased dispersion conclusions treatment psychotropic drugs influences tpte dispersion parameters might considered better estimate sudden cardiac death risk related specific medications beyond antipsychotics antidepressants mood stabilisers determine significant effects ventricular repolarisation
develop generic programming language parallel algorithms one works data structures control structures show parallel algorithm satisfying intuitively appealing postulates modelled collection cells abstract state machine augmented ability spawn new cells cells run algorithm communicate via shared global memory using formal definition makes algorithm effective prove validity parallel computation thesis according reasonable parallel models computation roughly equivalent running times
background epstein barr virus ebv plays causal role diseases including infectious mononucleosis lymphoproliferative diseases nasopharyngeal carcinoma detection ebv infection shown useful tool diagnosing ebv related diseases present study compared performance molecular tests including fluorescence situ hybridization fish ebv real time pcr serological assays detection ebv infection methods thirty eight patients infectious mononucleosis enrolled diagnosed mild type seven diagnosed haemophagocytic lymphohistiocytosis chronic active ebv infection twenty healthy controls involved study atypical lymphocytes peripheral blood detected microscope percentage positive cells calculated ebv dna load peripheral blood detected using real time pcr fish assay developed detect ebv genome peripheral blood mononuclear cells pbmc diagnosis methods including heterophil agglutination test ebv vca igm test detect ebv also compared spss used statistical analysis results atypical lymphocytes found among pbmc mild patients whereas atypical lymphocytes found patients haemophagocytic lymphohistiocytosis chronic active ebv infection patients significant difference ratios atypical lymphoma patients different types observed mild patients patients haemophagocytic lymphohistiocytosis chronic active ebv infection patients positive ebv vca igm ebv vca igm negative healthy control subjects addition mild patients tested heterophile antibody positive whereas patients haemophagocytic lymphohistiocytosis chronic active ebv infection tested positive ebv dna detected using real time pcr observed patients ebv genome detected fish assay patients viral loads detected fish real time pcr increased severity ebv genome detected almost pbmc haemophagocytic lymphohistiocytosis chronic active ebv infection patients conclusion molecular tests including fish ebv real time pcr sensitive serological assays detection ebv infection fish assay detecting ebv copies unfractionated whole blood preferable superior plasma real time pcr reflection absolute viral burden circulating patients
heat shock protein hsp homologous chaperone hsp pleiotropic functions drosophila melanogaster including control longevity fecundity facilitates morphological evolution buffering cryptic deleterious mutations wild populations pea aphid acyrthosiphon pisum hsp expression moderately induced bacterial infection upregulated strongly response heat stress fungal infection stress inducible heat shock proteins considerable evolutionary ecological importance known buffer environmental variation influence fitness non optimal conditions investigate functions hsp viviparous aphids used rna interference attenuate expression studied impact complex parameters rna interference rnai mediated depletion hsp expression pisum reduced longevity fecundity suggesting chaperone evolutionarily conserved function insects surprisingly hsp depletion reduced number viviparous offspring simultaneously increasing number premature nymphs developing ovaries suggesting unexpected role aphid embryogenesis eclosion present study indicates reduced hsp expression pisum reveals functional similarities differences compared reported roles holometabolous insects impact aphid lifespan fecundity embryogenesis suggests function determines fitness could achieved targeting different client proteins recruiting distinct chaperones transposon activation
background previous studies suggested pitx kcnn zfhx atrial fibrillation susceptibility genes single common genetic polymorphisms genes linked phenotypes rhythm outcome catheter ablation although mechanisms remain elusive new gene based association tests may help clarifying genotype phenotype correlations therefore hypothesized pitx kcnn zfhx associate left atrial enlargement persistent subsequently ablation outcome methods results samples patients paroxysmal persistent undergoing catheter ablation genotyped similar snps gene based association investigated using two different gene based association tests vegas minsnp among three candidate genes zfhx associated left atrial dilatation recurrence catheter ablation conclusion study suggests contribution zfhx remodeling response therapy future larger studies necessary replicate apply findings emphasis designing pathophysiology based multi locus risk scores
paper presents adaptive backstepping neural controller abnc achieve precise rotor position tracking nonlinear active magnetic bearing amb system modeling uncertainties external disturbances proposed abnc single hidden layer feedforward networks slfns used approximate unknown nonlinearities dynamic systems based approximated models neural controller constructed different existing methods hidden node parameters slfns determined using recently proposed neural algorithm named extreme learning machine elm parameters assigned randomly without adjusting simplifies controller design process using lyapunov theory stable tuning rules derived update output weights slfns proof stability uniformly bounded sense given resulting controller moreover relax online computation burden existing abnc simplified abnc simpl abnc less parameters adjusted online proposed improve control performance finally simulation results demonstrate proposed abnc simpl abnc achieve better tracking performance comparing controllers including pid controller conventional backstepping controller adaptive backstepping sliding mode controller also results show simpl abnc much less computation complexity also better tracking performance abnc elsevier rights reserved
view constitutes child abuse neglect dependent laws cultural context local thresholds availability since international society prevention child abuse neglect ispcan conducted surveillance child maltreatment child protection every two years published world perspectives child abuse hoped date information inform development laws policies programs better address child abuse neglect article based data child sexual abuse exploitation countries gathered online edition world perspectives respondents key informants knowledgeable professionals child protection field encouraged consult colleagues provide accurate information countries grouped different regions world income level categories findings focus definitions abuse neglect laws policies programs address prevent maltreatment barriers prevention evident considerable variability across regions country income categories programs services need considerably strengthened even high income countries published elsevier ltd
article analyses pattern introduction green technologies design social sphere objects building considered issues ecological economic justification effectiveness green innovations social construction segment comparative analysis international systems environmental certification namely breeam leed examples international domestic experience construction green objects example schools united states russia described article substantiates advantages green schools basis studies gregory katz authors published elsevier ltd
near infrared nir hyperspectral imaging system used detect five concentration levels ochratoxin ota contaminated wheat kernels wheat kernels artificially inoculated two different ota producing penicillium verrucosum strains two different non toxigenic verrucosum strains sterile control wheat kernels subjected nir hyperspectral imaging acquired three dimensional data reshaped readable two dimensional data principal component analysis pca applied two dimensional data identify key wavelengths greater significance detecting ota contamination wheat statistical histogram features extracted key wavelengths used linear quadratic mahalanobis statistical discriminant models differentiate sterile control five concentration levels ota contamination wheat kernels five infection levels non ota producing verrucosum inoculated wheat kernels classification models differentiated sterile control samples ota contaminated wheat kernels non ota producing verrucosum inoculated wheat kernels accuracy classification models also differentiated five concentration levels ota contaminated wheat kernels five infection levels non ota producing verrucosum inoculated wheat kernels correct classification non ota producing verrucosum inoculated wheat kernels ota contaminated wheat kernels subjected hyperspectral imaging provided different spectral patterns crown copyright published elsevier rights reserved
aimwe investigated preclinical abnormalities revealed transcranial sonography tcs patients idiopathic rapid eye movement sleep behavior disorder irbd compared revealed patients multiple system atrophy msa parkinson disease normal controls methodstwenty two patients irbd patients msa patients normal controls included study participants underwent one night video polysomnography monitoring sleep parameters analyzed using polysmith software visual analysis tcs performed following standardized procedure echogenicity substantia nigra basal ganglia evaluated resultsa greater proportion patients found substantia nigra hyperechogenicity compared irbd patients msa patients normal controls fourteen msa patients irbd patients hyperechogenicity basal ganglia whereas hyperechogenicity basal ganglia less frequent patients normal controls poor sleep efficiency less stage sleep time periodic leg movements found msa patients whereas irbd patients almost normal sleep conclusionsome irbd patients basal ganglia hyperechogenicity similar observed msa may represent another possible convert direction present study confirmed irbd prodromal stage synucleinopathy tcs could detect subclinical changes thus might provide useful markers identifying individuals increased risk developing synucleinopathy
work describe passive screen printed flexible tag gas monitoring used sealed environments developed measurement system based chemical sensors sensitive gases concentration presenting optical response luminescent colourimetric measuring electronics consist led optical excitation sensing membrane high resolution digital colour detector reading optical signal microcontroller receives processes data enabling detection threshold corresponding gas whole system powered two miniaturized solar cells provide one system run sunlight using bright artificial light energy source information inner environmental conditions regarding gas concentration transmitted user simple optical code using colour light emitting diodes leds activated indicate whether concentration monitored gas within expected limits two prototypes based architecture changing sensing module developed applied determination two common gases oxygen carbon dioxide first case luminescent chemical sensor used second sensing membrane presents colourimetric response types sensors used design resulting limits detection compatible assessment modified atmosphere packaging elsevier rights reserved
background dedicator cytokinesis dock deficiency combined immunodeficiency caused autosomal recessive loss function mutations dock disorder characterized recurrent cutaneous infections increased serum ige levels severe atopic disease including food induced anaphylaxis however contribution defects cells disease pathogenesis patients thoroughly investigated objective sought investigate phenotype function dock deficient cells determine intrinsic extrinsic cell defects defects account clinical features dock deficiency methods performed depth analysis cell compartment dock deficient patients enumerated subsets helper cells assessed cytokine production transcription factor expression finally determined levels ige specific staple foods house dust mite allergens dock deficient patients healthy control subjects results dock deficient memory cells biased toward type expense cells vitro polarization dock deficient naive cells revealed bias defect cell intrinsic examination allergen specific ige revealed plasma ige dock deficient patients directed staple food antigens house dust mites conclusion investigations dock deficient cells provided explanation clinical features disorder bias likely contribute atopic disease whereas defects cells compromise antiviral antifungal immunity respectively explaining infectious susceptibility dock deficient patients
various neurodegenerative disorders share clinical features sometimes renders differential diagnosis challenging genetic based classification also limitations mutations gene sometimes associated different clinically based diagnoses light screened corf neurodegeneration brain iron accumulation nbia causing gene corf intronic expansion mutation cause amyotrophic lateral sclerosis iranian parkinson disease patients corf previously screened patients one study best knowledge neither gene ever screened cohort middle east population study justified mutations corf previously shown common iranian neurodegeneration brain iron accumulation patients patients mutations gene exhibited parkinsonism features corf intronic expansion mutation screened mother iranian amyotrophic lateral sclerosis patient expansion diagnosed also harbored expansion screenings identify disease causing variations either genes among patients screened elsevier inc rights reserved
paper focuses development agent based intelligent distributed surface machining system structure traditional manufacturing engineering activity analysis systematic software engineering method advantages distributed system structure include ease manipulation high expandability flexibility achievement towards goal networked manufacture proposed system presented feasibility applying software agent based technology constructing distributed freeform surface machining environment several agents developed proposed system preliminary evaluation agent sophisticated evaluation agent post processor agent preliminary evaluation agent evaluation surface machining based surface curvatures sophisticated evaluation agent could accessed surface could machined three axis milling machine based calculation results preliminary evaluation agent suggest either four five axis machine could applied surface milling operation based visibility cone post processor agent takes care generation codes milling operation agent also convert five axis codes among different five axis milling machines machine mechanism could defined agents communicate via pre defined performatives underlying knowledge query manipulation language kqml surface machining capability developed system successfully implemented forming distributed shoe surface machining system means agent technology promising enhancing communication distributed system able communicate higher level knowledge rather remote function call platform independent networking architecture
large quantity recent research harvesting electrical energy ambient vibration sources focused improvement device performance via deliberate introduction dynamic nonlinearities addition realisation kinetic energy sources stochastic nature led many studies focusing response energy harvesters random vibrations often gaussian white noise differs early studies assumed ambient vibration sources sinusoidal aim present study take current nonlinear energy harvesting solutions numerically analyse effectiveness two real ambient vibration sources used human walking motion oscillation midspan suspension bridge study shows potential improvements realised introduction nonlinearities energy harvesters sensitive type ambient excitation subjected additionally need research development low frequency energy harvesters emphasised
hereditary angioedema hae rare debilitating autosomal dominant disorder caused mutations inhibitor gene results increased bradykinin levels usually misdiagnosed histaminergic angioedema occurs commonly associated urticaria report disorder young male presented dyspnoea recurrent bouts painful swelling involving various parts body abdominal cramps without signs urticaria patient diagnosed hae type based history poor response treatment histaminergic angioedema low inh antigenic levels
survey among elementary school children years old authors investigate extent children exposure news coverage violent news event related feelings fear worry anger sadness extent active helping children understand see news restrictive keeping children watching news parental mediation strategies moderate impact news findings show children news exposure significantly related emotional responses active mediation successfully reduces relations news exposure fear worry anger among younger children sample restrictive mediation even opposite effect however findings also suggest effectiveness mediation may depend child level news exposure
interstitial lung disease ild comprises spectrum chronic disorders cause various degrees inflammation fibrosis pulmonary interstitium although limited data exists nutritional concerns ild however previous research fully explored broad range potential nutritional concerns ild impacts outcomes purpose review identify describe overall nutritional status relating concerns within ild population appropriate weight management population may positively impact pre post transplant survival additionally accounting adequate muscle mass may predict better outcomes considering body mass index alone current research identified risk malnutrition related decreased muscle strength increased energy expenditure vitamin deficiency increased risk osteoporosis osteopenia current research preliminary research necessary identify established nutritional complications population
purpose triglycerides considered emerging risk factor cardiovascular mortality recent evidence relating depression metabolic syndrome mets implicated triglyceride levels thus investigated interrelations self reported depression severity zung mets related biological measures cvd risk estimates mets patients methods patients fulfilling international diabetes federation criteria mets nationwide sampled treatment cohort mets familial tdm risk manifest tdm ukrainian governmental health care system participants laboratory non laboratory measures included recent european cardiological score system cvd risk estimates used outcome variables results following correlation matrix entered variables principal component analysis pca explained variance followed hierarchical regression structural equation modeling sem pca suggested one factor solution latent variable showed highest loadings score risk estimates triglycerides depression severity pulse pressure comprehensive sem adjusted explained variance overall cvd risk related depression pulse pressure triglycerides fasting glucose conclusion findings mets sample suggest triglycerides depression severity key variables among mets biomarkers cross sectionally associating fatal total score risk estimates mets
picornavirus replication known cause extensive remodeling golgi endoplasmic reticulum membranes number host proteins involved viral replication complex identified including oxysterol binding protein osbp phosphatidylinositol kinase iii beta pikb since osbp pikb substrates protein kinase pkd pkd known involved control golgi membrane vesicular lipid transport hypothesized pkd played role viral replication present multiple lines evidence support hypothesis first infection hela cells human rhinovirus hrv induced phosphorylation pkd second pkd inhibitors reduced hrv genome replication protein expression titers concentration dependent fashion also blocked replication poliovirus foot mouth disease virus fmdv variety cells third hrv replication significantly reduced hela cells overexpressing wild type mutant forms pkd fourth hrv genome replication reduced hap cells pkd gene knocked clustered regularly interspaced short palindromic repeats crispr cas although identified molecular mechanism pkd regulates viral replication data suggest due enhanced interferon signaling inhibition clathrin mediated endocytosis pkd inhibitors need present viral uptake data show first time targeting pkd small molecules inhibit replication hrv fmdv therefore pkd may represent novel antiviral target drug discovery importance picornaviruses remain important family human animal pathogens limited arsenal antiviral agents hrv causative agent common cold relatively trivial infection however asthma chronic obstructive pulmonary disease copd patients virus major cause exacerbations resulting increased use medication worsening symptoms frequently hospital admission thus hrv represents substantial health care economic burden approved therapies sought identify novel host target potential anti hrv therapy hrv infection induces phosphorylation pkd inhibitors kinase effectively block hrv replication early stage viral life cycle moreover pkd inhibitors also block fmdv replication first description pkd may represent target antiviral drug discovery
objectiveto explore prevalence clinical profile males females develop antidepressant treatment emergent mania atem methodfrom original sample patients identified atem cases atem controls met stringent criteria specifically examined combinations clinical factors best classified males females atem cases resultsseventy five individuals classified atem atem events occurred antidepressant monotherapy regression analyses demonstrated presence alcohol substance use disorder odds ratio history one suicide attempts higher number depressive episodes per year illness correctly classified males contrast females correctly classified basis positive history thyroid disorder positive family history depressive onset polarity conclusionusing stringent definitions atem status reduce probability inclusion false positive cases false negative controls identified first time risk profiles development atem differ significantly according gender
investigation paper coupled hirota system describes ultrashort pulse simultaneous propagation field components optical fiber hirota method symbolic computation using auxiliary functions obtain improved bilinear forms two mixed type soliton solutions coupled hirota system system admits two mixed type solitons cases sigma sigma sigma represent defocusing focusing nonlinearities components help analytic graphic analysis study properties interactions two mixed type solitons coupled hirota system amplitudes two mixed type one solitons affected gamma velocities linearly related gamma gamma higher order effect represents relative width spectrum arises due quasi monochromocity bright dark two solitons exist elastic inelastic interactions bright dark two solitons elastic interaction bright dark bright dark bound state two solitons also presented finally extend results coupled hirota system elsevier ltd rights reserved
tuned mass damper tmd kind passive vibration reduction device widely used engineering structures howerver damping effect traditional tmd would decrease dramatically even small change main structure dynamic characteristics new kind smart material stiffness magnetorheological mre would change change magnetic field applied change stiffness mre adjust natural frequency tmd based idea proposed new kind frequency adjustable tmd based mre magnetorheological effect deformation mre mutually restricted allowable small deformation mre meet actual substantially deformation tmd paper deformation mre enlarged gear disk greatly increases amplitude frequency adjustable tmd based mre mechanical model new device deduced basis natural frequencies main structures identified combination hilbert huang transform heit random decrement technique rdt better damping effect achieved changing external magneitci field new kind tmd track natural frequencies main structure lastly pedestrian brige used engineering background simulation vibration control use frequency adjustable tmd calculated results show compared traditional tmd damping effect frequency adjustable tmd hardly affected change main structure natural frequency wider vibration frequency stable damping effect better deformation capacity frequency adjustable tmd
selective laser melting slm promising technique capable rapidly fabricating customized implants desired macro micro structures using computer aided design models however slm based products often non equilibrium microstructures partial surface defects steep thermal gradients high solidification rates occur laser melting meet clinical requirements heat treatment used tailor physiochemical properties homogenize metallic microstructures eliminate surface defects expecting improve cytocompatibility vitro compared printed substrate heat treated substrate hydrophilic rougher homogeneous surface promote early cell attachment proliferation osseointegration importantly crystalline rutile tio layer formed heat treatment greatly promote biocompatibility corrosion resistance implant compared untreated surfaces adhesion proliferation human bone mesenchymal stem cells hbmscs heat treated substrates significantly enhanced implying excellent cytocompatibility annealing therefore findings provide alternative biofunctionalized slm based implants optimized physiochemical properties biocompatibility orthopedic dental applications
parkinson disease neurodegenerative disease progressive loss mesencephalic dopaminergic neurons substantia nigra multiple incapacitating motor non motor symptoms troxerutin natural bioflavonoid nephro hepato protective antioxidant anti inflammatory properties study evaluated possible neuroprotective effect hydroxydopamine ohda rat model intrastriatal ohda lesioned rats pretreated troxerutin dose day week results showed troxerutin mitigates apomorphine induced motor asymmetry lowered latency initiate total time narrow beam task beneficial effect lost following central application estrogen receptor beta beta antagonist phosphatidylinositol kinase pik inhibitor addition troxerutin reduced striatal malondialdehyde mda index lipid peroxidation reactive oxygen species glial fibrillary acid protein gfap marker astrogliosis dna fragmentation apoptotic marker significant alteration catalase activity nitrite level meanwhile troxerutin capable prevent loss nigral tyrosine hydroxylase positive neurons findings indicate neuroprotective potential troxerutin ohda rat model mitigation apoptosis astrogliosis oxidative stress part effect dependent pik beta signaling
electricity sector undergoing major changes point view management market one keys accelerating change increasing penetration distributed energy resources ders complexity scenario envisaged near future requires equipment electrical network must capacity interact much dynamic way current system connection interface provided necessary intelligence communication capability manage whole system effectively paper describes development intelligent electronic device ied integrate current future grid equipment specifications considerations design well multifunctional architecture discussed developed prototype subjected testing protocol class according iec check monitoring parameters various tests estimating delays involved protection algorithms presented also finally real test scenario discussed prototype integrated inverter providing capabilities required future smart grid context
infant exposures metals concern mining impacted communities although limited information available assess residential exposures first year life measured lead manganese arsenic cadmium indoor air house dust yard soil tap water infants homes near tar creek superfund site oklahoma usa two time points representing developmental stages initial ambulation age months measured infant metal biomarkers umbilical cord blood month blood hair age months evaluated cross sectional longitudinal associations infant residential biomarker concentrations doubling mean dust concentration consistently associated higher month blood adjusting cord blood adjusted dust concentration explained blood variance consistent associations media observed although concentrations dust blood generally low strong consistent associations dust body burden suggest house dust mining impacted communities may impact children health relationships observed young age typically blood levels peak children development may particularly vulnerable toxic insult
integration microcontrollers limited devices conventional service oriented architectures soa based systems presented paper systems serve mainly data acquisition soft real time control microcontroller role embedded device receive commands powerful device personal computer apply respective signals sensors actuators soa based system organization helps system expansion maintenance standardized way since implementation soa requires large code data memory making unsuitable embedded systems propose solution introducing concept bind server bind server takes responsibility complex tasks leaving microcontroller deal simple ones report small sizes code messages exchanged server implemented microcontroller
paper fundamentally new approach computer aided design simulation electrical circuits based use lambda calculus circuit device model representation dynamic sizeable containers sparse matrix simulation indexation indices presented approach differs traditional procedure entire simulation performed matrix matrix system assembled modified nodal analysis mna turning device model definitions using lambda calculus functionals allowed reduce effort required specification opened new possibilities simulation evaluation considering mna matrix second order tensor system holding functional definition original sparse matrix entries allows imagine dependencies chains respect model definition global dependencies defining inner functions particular case standard indexing methods would waste memory computation problem occurs huge sparse matrices enter simulation therefore new optimized indexing technique non zero matrix entries variable size container types indexation vectors proposed
water energy consumption increased substantially last decades water scarcity led increase extraction fresh water aquifers dams lakes produced serious overexploitation problems furthermore population growth urbanized areas increase water energy demands industry agriculture households amplified problem consequence several regions almost impossible satisfy water demands using available water resources context use alternative water resources reclaimed water rainwater harvesting potential use desalinated water option however desalinated seawater expensive high energy consumption way integrate seawater desalination plant power plant simultaneously produce clean water power attractive option way paper proposes optimization formulation synthesizing water networks satisfy water energy demands macroscopic system involving use existing water resources installation integrated seawater desalination power plants case study mexico satisfying water demands become serious problem presented results show integrated system able satisfy current water demands excess desalinated water used recharge overexploited aquifers interesting profits obtained sales power elsevier rights reserved
background season vitamin indirect direct correlates ultraviolet radiation associated pregnancy outcomes producing vitamin positive effects cardiovascular immune health may support role directly benefitting pregnancy objectives investigate effects exposure pregnancy specifically fetal growth preterm birth hypertensive complications methods conducted systematic review medline embase dopher global health proquest public health austhealth informit scopus google scholar identify citations included review review registered prospero narrative synthesis presented following prisma guidance results studies observational assessed high risk bias higher first trimester associated improved fetal growth increased hypertension pregnancy interpretation limited study design quality meta analysis precluded variety outcomes methods discussion low number studies risk bias limit validity conclusions environmental health methodological issues discussed consideration given design analytical improvements address reproductive environmental health question conclusions evidence benefits pregnancy hypertension fetal growth limited methodological approaches utilized future epidemiological efforts focus improving methods modeling linking widely available environmental data reproductive health outcomes
paper deals novel fast swimming robotic fish capable high maneuverability yet less joints basis prior work single motoractuated miniature robotic fish mainly stress three aspects mechanical design motion analysis posture control strike tradeoff speediness maneuverability specifically improved mechanical structure endows robot large thrust increased range movements motion analysis offers useful guidance parameter settings steady swimming besides sine based functions responsible generating travelingwaves conjunction analysis parameter variation oscillation amplitude fish tail serve purpose determine posture robotic fish underwater tests straight swimming different turns demonstrate effectiveness proposed methods mechatronic designs remarkably robot attained amaximumswimming speed corresponding body lengths per second forward swimming turning rate approximately degrees normal turns turning rate approximately degrees hybrid turns
purpose analyze efficacy tocilizumab uveitic macular edema resistant various immunomodulatory drugs methods patients received tocilizumab every weeks intravenously central foveal thickness cft assessed optical coherence tomography oct results five patients eyes ineffectively pretreated systemic prednisolone least one immunosuppressive drug least one biologic drug uveitic macular edema included study months response reduction cft observed eyes patients follow complete resolution achieved eyes patients improvement bcva observed eyes patients stabilization eyes patients tocilizumab well tolerated severe side effects occurred conclusions treatment tocilizumab considered chronic uveitic macular edema even previous immunomodulatory therapy failed
previous reports demonstrated bone density decreased rapidly initial months steroid therapy continued decreasing rate annually data indicates denosumab also play role treatment osteoporosis steroid taking population introduction respiratory physicians often faced dilemma long term steroid use deteriorate bone mineral density quality previous reports demonstrated bone density decreased initial months steroid therapy continued decreasing rate annually several prospective trials revealed denosumab increased bone density patients osteoporosis decreased rate occurrence fractures long term efficacy denosumab glucocorticoid induced osteoporosis however yet proven materials ongoing prospective study since respiratory centre first preventative measure used combat glucocorticoid induced osteoporosis gio oral bisphosphonates thirty six patients enlisted treatment courses changed oral bisphosphonate administered subcutaneous injection denosumab every months combined daily oral intake denotas chewable combination tablets primary efficacy measures changes lumbar spine bone mineral density bmd femoral bmd baseline months results month follow bone mineral density lumbar spine area patients increased bone mineral density hip area showed significant increase month follow patients still included study femoral bmd months increased significantly month follow though first months showed significant increase bmd continued increase month period conclusions little known regarding active prevention gio data indicates denosumab play promising role treatment gio
security features privacy device authentication required wireless sensor networks electronic ids radio frequency identification tags many applications features provided using cryptography symmetric key cryptography key distributed communication parties prior communication provide adequate solution large scalable systems sensor networks cases public key cryptography used however public key algorithms typically computationally intensive symmetric key counterparts creates difficulties meeting strict area power energy requirements elliptic curve cryptography relatively small operand sizes used answer imposed challenges paper present processor elliptic curve cryptography processor perform elliptic curve point multiplication well general modular operations processor flexible enough support multiple cryptographic protocols chip fabricated using umc process resulting core area energy consumption perform one elliptic curve point multiplication design features lightweight countermeasures side channel attacks security evaluation shows effectiveness countermeasures copyright john wiley sons ltd
researchers use race conduct health care studies definition question belief race social construct without biological authenticity though widely shared across disciplines social science subscribed traditional science yet interdisciplinary approach two horns social construct genetics dilemma race mutually exclusive use traditional science provide rigorous framework use social science approach invisible factors used adjust design studies needed basis one approach first observe health care outcomes categorize outcomes thus removing genetic differences racial proxies design study outcomes determine pattern conceivable racial categories needed apply dynamic notions race acknowledge bias without prejudice use constructively improve outcomes reduce racial disparities another approach nearly identical considers race analyzing outcomes determine biological differences significant enough identify classifications humans look genetic patterns outcomes classify patterns attempt link patterns race
public key cryptography pkc based multivariate quadratic equations one promising alternatives classical pkc eventual coming quantum computers recently shen tang proposed new signature scheme rgb based three types variables red green blue claimed signing rgb faster uov rainbow acisp tang implemented rgb spv microprocessors bit security levels practical use results much efficient signature schemes rgb appealing resource limited devices show rob suggested parameters security levels entirely broken key recovery attacks using good keys practical point view able break parameters security levels less seconds seconds seconds minutes hours respectively consequently show signing key sizes rgb secure parameter sets much slower larger uov rainbow elsevier inc rights reserved
osteoporosis elderly men recognized problem current study intend look performance two risk assessment tools osta andmores diagnosis osteoporosis osteoporosis seen elderly men spine femoral neck risk assessment tools found good sensitivity predicting osteoporosis spine femoral neck good area curve auc purpose study attempts look performance osteoporosis self assessment tool asians osta male osteoporosis risk estimation score mores predicting osteoporosis south indian rural elderly men methods five hundred twelve men years age south indian rural community recruited cluster random sampling subjects underwent detailed clinical anthropometric bone mineral density measurement lumbar spine femoral neck using dual energy ray absorptiometry scan atscore diagnostic osteoporosis scores osta andmores calculated various cut offs sensitivities specificities predicting osteoporosis derived results prevalence osteoporosis found femoral neck spine ostawith cut value predicted osteoporosis spine sensitivity specificity femoral neck respectively area roc curve mores spine femoral neck conclusion osta andmores found useful screening tools predicting osteoporosis indian elderlymen tools simple easy perform cost effective context rural indian setting
two circuit solutions fully differential current mode band pass filter presented paper main feature circuits quality factor electronically adjusted independently natural frequency omega via single active element namely digitally adjustable current amplifier daca control directly indirectly proportional current gain daca depending circuit structure used behavior proposed structures verified spice simulations
paper presents neural network controller reducing ship roll motion using active fin stabilizers classical pid controllers fail control ship roll dynamic parameters ship change innovative approach used overcome disadvantage wherein three different conditions ship stability chosen pid controller tuned separately cases training data derived pid controllers design neural network controller controller thereafter fine tuned considering various input combinations training different number hidden neurons design best neural network controller reducing ship roll controller also intended avoid ship sinking worst stability conditions
background concept myeloproliferative neoplasms mpns introduced william dameshek grouping together chronic myeloid leukaemia cml polycythaemia rubra vera prv essential thrombocythaemia primary myelofibrosis pmf erythroleukaemia self perpetuating trilineage myeloproliferation underlined pathogenesis jak one janus kinases non receptor tyrosine kinases integral part cytokine growth factor signalling autoinhibitory function released gain mutation jak mutation leads downstream activation several signalling cascades like stat proteins pik akt pathway mitogen activated protein kinases recent studies suggest mutations tet tumour suppressor gene found jak mpns jakvecases likely precede acquisition jak mutation detection mutation direct sequencing restriction fragment length polymorphism allele specific pcr jak exon mutation specific jak negative prv jak deletion frequent among ones described patients usually heterozygous mutation erythroid myelopoiesis subnormal serum erythropoietin levels younger age diagnosis apart bcr abl mutation others include jak jak exon mpl kit calreticulin tet mutations objectives study study clinico morphologic features myeloproliferative neoplasms reference revised classification myeloid neoplasms study prevalence jak region materials methods descriptive study set haematology clinical pathology laboratory mch thiruvananthapuram bone marrow samples obtained department medicine show features mpns selected based revised criteria selected cases clinical history collected compared peripheral smear bone marrow aspirate trephine reticulin stain mpn typed jak study advised cases prv results total myeloproliferative neoplasms studied male predominance frequent age group years cases polycythaemia rubra vera followed essential thrombocythaemia chronic myeloid leukaemia progressive myelofibrosis chronic neutrophilic leukaemia chronic eosinophilic leukaemia cases incidentally detected statistically significant relationship noted presenting complaint type mpn cases mpn studied jak mutation status well showed positivity cases lost followup among jak positive cases presented thrombotic episodes splenomegaly conclusion cases mpn studied cases selected accordance classification myeloid neoplasms polycythaemia rubra vera commonest cases prv cimf cnl cel identified frequency compared earlier study conducted department probably increased awareness conditions also better clearcut diagnostic criteria available
previous research shown prior knowledge structures schemas affect recognition memory however since acquisition schemas occurs prolonged periods time paradigms allow direct manipulation schema acquisition study effect memory performance recently number parallelisms recognition memory studies involving schemas studies involving category learning identified current paper capitalizes findings offers novel experimental paradigm allows manipulation category learning individuals study effects schema acquisition recognition first participants learn categorize computer generated items whose category inclusion criteria differ participants next participants study items belong either learned category non learned category neither finally participants receive recognition test includes old new items either learned non learned neither category using variations paradigm four experiments conducted results first three studies suggest learning category increases hit rates old category consistent items false alarm rates new category consistent lures absent category learning effects evident even participants exposed learning trials learned categories results fourth experiment suggest least false alarm rates effects category learning solely attributable frequency occurrence category consistent items learning implications recognition memory well advantages proposed paradigm discussed
paper considers financial costs rapid national transition electric vehicles evs comparison baseline scenario characterised continuing use internal combustion engine vehicles ices australian car fleet responsible national greenhouse emissions used case study explore potential range costs associated rapid climate mitigation via transport sector transition assumed occur rapidly analysis focusses urban areas extensive charging infrastructure assumed made available including rapid charging facilities due uncertainty input variables two boundary scenarios constructed high cost scenario rapid shift evs found cost approximately continuing use ices assessed period however low cost scenario costs evs especially batteries fall rapidly maintenance costs lower end projections liquid fuel costs higher end projections rapid transition evs found cost approximately use ice vehicles suggests rapid transition towards technologies urban car travel may offer cost effective second best climate change mitigation strategy comprehensive transport sector transformation including changes transport land use policy designed facilitate mode shift might reduce costs transition elsevier ltd rights reserved
nicotine replacement therapy effective intervention smoking cessation adherence tends low article presents results pilot evaluation brief smoking cessation treatment improve adherence nicotine patch among latino smokers living hiv aids forty smokers randomized receive either standard counseling session week treatment nicotine patch similar intervention added min module counseling focused improving adherence nicotine patch smoking outcomes breath carbon monoxide monitoring verified day point prevalence continuous abstinence evaluated month follow patch usage follow period also assessed intention treat analyses indicated abstinence rates times higher adherence condition compared standard condition day point prevalence abstinence continuous abstinence nicotine patch compliance week period also higher adherence condition standard condition although small pilot conducted estimate effect sizes powered detect group differences results promising suggest adding min module focused nicotine patch adherence standard protocol increase abstinence rates given smoking cessation treatment specifically tailored either hiv positive smokers latino smokers future research examine whether may promising approach improving nicotine patch adherence general population smokers
background hepatitis virus hcv risk elevated individuals opioid use disorder oud routine hcv testing recommended high risk individuals including injection drug use history hcv antibody testing addresses first step hcv treatment care cascade uptake completion hcv treatment among individuals chronic hcv optimal care cascade endpoint aim study characterize self reported hcv treatment cascade outcomes among individuals oud outpatient medication assisted treatment mat methods individuals receiving methadone buprenorphine treatment female age completed brief anonymous paper pencil survey examining self reported history hcv testing diagnosis treatment descriptive statistics characterized hcv treatment cascade outcomes results majority endorsed lifetime hcv testing history tested hcv past year lifetime hcv testing history indicated told hcv individuals reporting told chronic hcv chronic hcv reporting receipt hcv treatment discussion results underscore gaps hcv care continuum among individuals oud mat interventions increase uptake hcv testing communication hcv diagnostic treatment information medical providers linkage hcv medical care uptake adherence hcv treatment urgently needed particularly among individuals oud mat elsevier inc rights reserved
purpose review migraine common disorder causing attacks neurological dysfunction pain treatment ranges pharmacological lifestyle changes improve frequency severity attacks focus lifestyle changes especially diet often discussed clinical visits care migraine patients recent findings diet may play role triggering migraine available evidence migraine diet limited advising patients dietary changes improve migraine important acknowledge limits evidence larger role diet may play lifestyle changes summary review focus current evidence effect diet migraine use case illustrate approach diet changes patient migraine
paper describes inerter based device structural vibration suppression realized using electromagnetic transducer linear motor motor shaft moves difference voltage generated across transducer coil voltage difference proportional relative velocity two terminals electromagnetic transducer exert force proportional current following lorentz principle circuit closed around transducer coil electronic circuit consisting capacitor inductance resistance appropriate configuration connected resulting force reflected back mechanical domain equivalent achieved mechanical inerter based device proposed configuration easy implement versatile provided high quality conversion system negligible losses use electromagnetic devices new generation vibration absorbers realized example electrical domain would relatively uncomplicated synthesize multi frequency real time tunable vibration absorbers adding electrical components parallel addition using resistance emulators electrical circuits part absorbed vibration energy converted usable power electromagnetic tuned inerter damper tid tested experimentally using real time dynamic substructuring voltage compensation unit developed order compensate coil losses voltage compensation unit requires power acquired harvesting vibration energy using resistance emulator power balance analysis developed order ensure device self sufficient promising experimental results using approach obtained presented paper ultimate goal research development autonomous electromagnetic vibration absorbers able harvest energy convert usable power use vibration control health monitoring
aim present study determine repairing effects intercellular adhesion molecule icam expressing mesenchymal stem cells mscs mice autoimmune thyroiditis following induction experimental autoimmune thyroiditis eat model mice randomly divided following groups normal control experimental groups subject eat induction including eat model iii primary msc cht msc cht migr msc cht migr icam msc administered relevant cells mscs administered via caudal vein blood sample harvested angular vein animal days post treatment elisa used determine serum total triiodothyronine total thyroxine thyroid stimulating hormone tsh anti thyroid peroxidase tpoab anti thyroid microsomal tmab anti thyroglobulin tgab antibodies hematoxylin eosin staining performed evaluate injury thyroid gland determining size follicle inflammatory infiltration colloidal substance retention epithelial injury reverse transcription quantitative polymerase chain reaction performed determine mrna expression interleukin interferon inf western blot analysis performed determine expression mitogen activated protein kinase extracellular signal regulated kinase erk observe cellular migration vivo mice divided following groups subject eat induction dii labeled primary msc dii labeled cht msc iii dii labeled cht migr msc dii labeled cht icam msc administered relevant cells via caudal vein cht icam mscs able ameliorate expression tsh tpoab tmab tgab vivo attenuate thyroid follicle injury decrease splenic index mice also able ameliorate mrna expression inf modulation erk signaling pathways mouse spleen furthermore icam overexpression able modulate nesting mscs thyroid gland lung findings suggest cht icam msc may affect differentiation proliferation migration immunocytes modulating erk signaling pathways icam may modulate immunoregulatory effects mscs affecting migration mscs vivo
significant changes satellite detected net primary production npp mgcm observed southern ocean increase pacific sector decrease atlantic sector clear physical forcing identified hypothesize changes npp associated changes phytoplankton community reflected concomitant bio optical properties satellite algorithms chlorophyll concentration chl mgm use combination estimates remote sensing reflectance rrs statistically fitted global reference data set particular region point space time estimate produced global mean algorithm deviate true value reflectance anomaly supposed remove first order variability rrs associated chl reveal bio optical properties due composition phytoplankton associated materials time series showed variability multiple scales including life span sensor multiyear annual models plankton functional types using estimated chl input expected correctly resolve regional seasonal anomalies due biases chl estimate based statistical model using time series predict times series npp high accuracy pacific atlantic regions underlying mechanisms terms phytoplankton groups associated materials remain elusive
risks uncertainties inherent construction industry industry industry exhibits poor management risks hence many projects fail meet time schedules budget targets transport sector important part construction industry vital growth however sector severely affected delayed completion projects exceeded cost issues pronounced terrorism affected areas around world predominantly pakistan afghanistan iraq evaluation risk factors causing cost overrun road projects terrorism affected areas pakistan case study pakistan top ranked terrorism affected country among terrorist affected countries around world taken case study pakistan federally administrated tribal area fata recipient max casualties focus study fata received maximum share development projects especially road infrastructure however projects could fulfill desired purpose due lack evaluation risks associated dynamics culture area resulting severe cost overrun projects study presents mechanism identify key risk factors contributing failure achieving budget targets road projects fata suggests measures overcome study undertaken via questionnaire based survey comprising cost overrun risk factors ranked using mean weightage analysis results show non availability suitable contractors project location within fata idling cost plant equipment due security threats differing site conditions project inaccurate survey site investigation due security threat major factors responsible cost overrun moreover responsibility among stakeholders risks also established results study warrant adoption proactive measures effective management risks owner consultants contractors avoid budget escalation road construction projects terrorism affected area around world
inspired social networks complex systems propose core periphery network architecture supports fast computation many distributed algorithms robust uses linear number links rather providing concrete network model take axiom based design approach provide three intuitive independent algorithmic axioms prove network satisfies axioms enjoys efficient algorithm range tasks mst sparse matrix multiplication also show necessity axiom set networks satisfy subset axioms efficiency guaranteed deterministic algorithm elsevier inc rights reserved
purpose study determine relationship food related parenting practices child fruit vegetable high fat sugar food preferences parents children years old completed comprehensive feeding practices questionnaire cfpq preschool adapted food liking scale pals answered demographic questions separate linear regressions conducted test relationships different food categories pals fruits vegetables high fat sugar foods food related parenting practice using race ethnicity income level child age gender covariates found parent allows child control eating negatively associated child preference fruit beta parent encouragement child involvement meal preparation positively related child preference vegetables beta children preferred high fat sugar foods parents used food regulate child emotions beta used food reward beta pressured child eat food beta restricted unhealthy food beta conversely children preferred high fat sugar foods less parents made healthy food available home beta modeled healthy eating front child beta parents explained healthy foods consumed beta although determined parent influencing child vice versa study provides evidence coercive feeding practices detrimental child food preferences elsevier ltd rights reserved
aimsto describe clinical characteristics assess beliefs coping strategies older patients overactive bladder oab attending urology gynecology clinics spain methodsthis non interventional multicenter cross sectional study collected demographic clinical details individuals aged years diagnosis oab score patient perception intensity urgency scale symptoms assessed using bladder control self assessment questionnaire saq health related quality life hrqol rated using simple visual analogue scale coping strategies oab beliefs assessed using two specially designed questionnaires resultspatients reported mean urinary urgency episodes urgency urinary incontinence uui episodes per mean times since diagnosis symptom onset months respectively saq symptom bother scores respectively patients reported worse hrqol symptom onset approximately patients considered symptoms normal age gender expected symptoms worsen age time however believed symptoms would improve treatment coping strategies patients changed urinary frequency controlled fluid intake used pads use coping strategies associated severity conclusionsmany older individuals view oab symptoms normal feature age may delay diagnosis reduced hrqol adoption coping strategies also common results support need improved patient education earlier recognition effective intervention older oab population neurourol urodynam wiley periodicals inc
aim determine whether serum drug concentrations obtained neonate umbilical cord used prognostic factor admission neonatology ward occurrence withdrawal symptoms retrospective observational monocenter cohort study carried among pregnant women using psychotropic drugs baby binary logistic regression used multivariate analysis neonates included admitted neonatology ward withdrawal among women therapeutic concentrations psychotropic medication neonates withdrawal symptoms comparing neonates therapeutic versus undetectable drug concentrations odds ratio confidence interval found admission neonatology ward odds ratio confidence interval occurrence withdrawal symptoms therapeutic concentrations psychotropic drugs neonates umbilical cord blood correspond higher odds admission neonatology ward occurrence withdrawal symptoms compared neonates undetectable drug concentrations measurement drug concentrations neonate may contribute toward general clinical assessment physician predict necessity admission neonatology ward risk withdrawal symptoms
output stability displacement sensors important issue safe operations magnetic bearing supported high speed rotor system paper proposes effective postprocessing solution problems temperature drift synchronous measuring error axial displacement sensor magnetically suspended motor proposed configuration axial displacement sensor consists three probes one pair used eliminate synchronous measuring error third probe employed consideration temperature drift first generating mechanism synchronous measuring error caused improper assemble presented operational amplifier proposed obtain accurate position axial center adjusting weights sensing signals one pair probes scheme temperature compensation using auxiliary probe presented order obtain accurately characteristics temperature drift operating point detailed procedure given determine temperature drift ratio finally terms related temperature drift synchronous error final output displacement sensor eliminated experimental results magnetically suspended motor test rig show effectiveness proposed solution
accurate design low power voltage controlled oscillator vco enabled quantizer continuous time sigma delta adc cmos technology using tanner eda tools done proposed architecture consists loop filter vco quantizer dac feedback side model operational amplifier opamp used designed loop filters offers gain degree phase margin unity gain bandwidth mhz consuming power even order harmonics vco reduced vco quantizer loop structures higher order loop filter designed using active resistance capacitive based integrators vco quantizer implemented using multiple stage ring oscillator register dff provides added advantage low phase noise frequency khz rang remarkable power dissipation overall circuit
increasingly serious energy crisis environmental pollution short term economic environmental hydrothermal scheduling seehts problem becoming important modern electrical power systems order handle seehts problem efficiently parallel multi objective genetic algorithm pmoga proposed paper based fork join parallel framework pmoga divides whole population individuals several subpopulations evolve different cores simultaneously way pmoga avoid wastage computational resources increase population diversity moreover constraint handling technique used handle complex constraints seehts selection strategy based constraint violation also employed ensure convergence speed solution feasibility results hydrothermal system different cases indicate pmoga make utmost system resources significantly improve computing efficiency solution quality moreover pmoga competitive performance seehts compared several methods reported previous literature providing new approach operation hydrothermal systems
many core architectures trade single thread performance larger number cores scalable throughput attained high degree parallelism minimized synchronization whilst achievable many applications operating system still introduces bottlenecks non local sharing synchronization message passing particular challenge highly dynamic applications example invasive hpc applications elastic compute clouds management short living application threads processes paper discusses architecture choices based microkernel multikernel distributed systems designs development experience context mythos project initial experiments show much faster thread creation activation compared monolithic systems like linux providing flexible protection threading model better suited dynamic scenarios however despite significant progress overall domain operating systems design space scalable many core operating systems yet fully explored
background rubber additives constitute important group contact allergens particularly certain occupations objectives collect information regarding current practice using rubber series europe discuss background evidence concerning prevalence allergy order derive recommendation european rubber series methods following performed survey targeting members cost action standerm consortium analysis rubber contact allergy data database european surveillance system contact allergies iii literature review results information countries available one several departments dermatology occasionally occupational health apart substances tested single departments broad overlap regarding important allergens evident considerable variation existed departments conclusions date european rubber series recommended exclusion substances historical concern supplementary rubber series containing allergens less proven importance requiring analysis recommended departments specializing occupational contact allergy continually updated new evidence emerges
water pollution incidents cause rapid deterioration water quality potentially leading illness death surrounding residents therefore imperative assess impact water pollution incidents understand mechanisms pollutant transport transformation address problem paper constructed hydraulic water quality model lower reaches xiangjiang river china using hydrodynamic module convective diffusion module mike six pollution incident scenarios simulated investigate transport process pollutants affected upstream dam structure changsha comprehensive control project dam cccp analysis results suggests cccp plays essential role controlling transport transformation pollutants cccp process transport weakened dispersion effect strengthened particular construction cccp amount upstream discharge leads lower peak pollutant concentrations longer pollutant arrival times waterworks intake thereby alleviating impact water pollution incidents comparative analysis suggests role cccp much significant lower discharges dry season largely due higher amount water quantity within reach
review sad hypothesis kamstra hereafter kkl isolates four new problems first kkl statistical model test kkl sad hypothesis second kkl properly interpret results third kkl incorrectly specify sign sad effect winter revised sad hypothesis hours night negative influence stock returns fall winter fourth statistical tests support either kkl hypothesis revised sad hypothesis elsevier inc rights reserved
systemic lupus erythematosus sle autoimmune disease characterized extensive immune response including activation cell development pathogenic autoantibodies organ damage induced formation deposition immune complex abnormal elevation type interferon semaphorina semaa involved essentially immune cell regulation also implicated pathogenesis autoimmune disorders aimed evaluate role semaa patients sle serum levels semaa tested enzyme linked immunosorbent assay elisa sle patients healthy controls message ribonucleic acid mrna expression levels semaa adam metallopeptidase domain adam peripheral blood mononuclear cells pbmc patients sle healthy controls detected real time quantitative polymerase chain reaction qpcr serum semaa levels increased significantly sle patients compared healthy controls elevated levels semaa correlated positively proteinuria excretion sle disease activity index sledai reactive protein crp negatively planet plt complement sle patients patients elevated semaa levels showed higher incidence rash serositis nephritis patients decreased plt positive proteinuria also showed elevated semaa mrna adam increased sle patients correlated positively serum semaa levels data demonstrated elevated serum semaa sle patients correlated disease activity involved kidney blood system damage adam might involved release secreted semaa
background pain related conditions reported play key role among risk factors suicide headache particular repeatedly associated suicidal thoughts behaviors aims study assess association lifetime headache non migrainous headache migraine lifetime suicide attempts differentiate within subjects lifetime patients without lifetime headache terms socio demographic clinical features methods studied subjects cohort community dwelling persons aged years without dementia esprit study divided two groups without lifetime logistic regression analyses used compare groups according lifetime headache status results adjusting gender living alone tobacco alcohol consumption depressive manic hypomanic anxiety disorders lifetime headache frequency significantly higher subjects lifetime compared controls additionally different factors identified associated lifetime participants lifetime headache female gender lower level high density lipoprotein cholesterol insomnia lifetime major depression versus participants without headache glycemia lifetime major depression conclusions lifetime headache associated lifetime subjects women report occurrence headache insomnia well lifetime major depression require higher attention careful screening suicidal thoughts behaviors elsevier masson sas rights reserved
bioactive food chemicals substances present food capable interacting living cells causing changes physiological functions salicylic acid plant hormone involved plant immune response one bioactive food chemical aspirin commercially available might play beneficial roles cardiovascular health colon cancer may also cause urticaria angioedema asthma gastrointestinal symptoms sensitive individuals dietary might exert similar beneficial effects may induce similar symptoms hypersensitive individuals food related sensitivity relation gastrointestinal symptoms well documented besides self reported questionnaires knowledge low doses aspirin equivalent high dietary intake cause gastrointestinal injury direct evidence suggests benefits reducing dietary reported asthmatic individuals although sensitivity relation gut symptoms susceptible individuals accepted clinicians detection disease remains challenge complicated nature dietary challenges risk oral aspirin provocation tests patients severe hypersensitivity reactions given non ige mediated nature disease vitro assays like basophil activation may failed produce reliable results however given simplicity assay studies need formulated firmly establish reliability formulation proper dietary strategies symptom control also impossible given controversial scant nature data content food issue needs resolved formulate proper dietary strategies effective symptom control
urgent requirement examine quality harvested rainwater potable non potable purposes based type roofing material study examined effect quality harvested rainwater conventional roofing materials concrete asphalt ceramic tile roofs compared alternative roofing materials green roof results showed ceramic tile roof suitable rainwater harvesting applications lower concentrations leachable pollutants however study green roof suitable rainwater harvesting applications addition seasonal trends water quality parameters showed pollutants roof runoff summer autumn lower winter spring study revealed quality harvested rainwater significantly affected roofing material therefore local government urban planners develop stricter testing programs produce weathering resistant roofing materials allow harvesting rainwater domestic public uses elsevier ltd rights reserved
endometrial cancer major cancer women traditionally divided type type well known type endometrial cancer poor prognosis studies suggested estrogen receptor progesterone receptor positive positively associated endometrial cancer survive however whether positivity different cancer types investigated yet retrospective study positivity analysed women primary diagnosed endometrial cancer taking account cancer types menopausal status largest university teaching women hospital china positivity significantly higher type compared type endometrial cancer premenopausal postmenopausal women different positivity type endometrial cancer premenopausal postmenopausal women however type endometrial cancer positivity premenopausal women significantly higher compared postmenopausal women data demonstrate positivity significantly higher type endometrial cancer compared type positive positive menopausal status associated positivity type endometrial cancer data may provide novel insights asian women better outcomes endometrial cancer reported literature
studies tackling hysteresis identification technical literature follow white box approaches rely assumption measured data obey specific hysteretic model assumption may hard requirement handle real applications since hysteresis highly individualistic nonlinear behaviour present paper adopts black box approach based nonlinear state space models identify hysteresis dynamics approach shown provide general framework hysteresis identification featuring flexibility parsimony representation nonlinear model terms constructed multivariate polynomial state variables parameter estimation performed minimising weighted least squares cost functions technical issues including selection model order polynomial degree discussed model validation achieved broadband sine conditions study carried numerically exploiting synthetic data generated via bouc wen equations elsevier ltd rights reserved
background multiple sclerosis prevalent autoimmune inflammatory demyelinating disease central nervous system cns young adults genomic regions associated susceptibility due important immune modulating properties vitamin vitamin receptor vdr gene polymorphisms interfere actions vitamin could related increased risk methods studied patients fulfilling mcdonald criteria females males healthy unrelated controls nested case control study recruited national institute neurology neurosurgery manuel velasco suarez mexico city genotyping vdr gene polymorphisms bsmi taqi performed using taqman snp genotyping assay consists predesigned mix unlabeled polymerase chain reaction pcr primers taqman minor groove binding group mgb probe fam dye labeled results statistically significant positive association genotype bsml polymorphism showing also significant positive trend across genotypes association also present evaluating recessive inheritance model polymorphism evaluating association alleles statistically significant positive association seen genotypes confirmed allele carriers showing conclusions found positive association genetic vdr polymorphisms taql bsml risk sample mexican adults elsevier rights reserved
edge extraction high spatial resolution hsr remotely sensed images one essential tasks image segmentation object identification present optimal gabor based edge detection method mainly focuses selecting optimal parameters including central frequency spectrum scale gabor filter central frequency automatically optimized phase randomization human visual system based structure similarity index next optimal spectrum scale determined based two dimensional power spectrum density edge detection method comprehensively discussed analysis parameter sensitivity overall performance comparative tests several widely used methods qualitative quantitative experimental studies performed six test images various spatial resolution show proposed method provides promising solution edge detection hsr remotely sensed images society photo optical instrumentation engineers spie
novel coo nanocomposite application photo catalytic evolution designed fabricated first time work structure morphology coo investigated wide range characterization methods obtained coo composites exhibited efficient utilization solar energy pure resulting higher photocatalytic activity evolution optimum photoactivity evolution visible light irradiation coo composites coo mass content mol times high pure mol remarkably increased photocatalytic performance coo composites mainly attributed synergistic effect junction interface formed coo
objective compare effectiveness tolerability carbetocin versus syntometrine prevention postpartum hemorrhage pph cesarean section methods double blind randomized study conducted pregnant subjected randomly either single dose carbetocin women combination oxytocin ergometrine women fetal extraction placental removal primary outcome parameter occurrence pph parameters hemoglobin hematocrit changes need additional oxytocic hemodynamic changes occurrence side effects results significant difference two study groups regarding hemoglobin hematocrit start days surgery mean blood loss operation highly significant difference two study groups regarding incidence primary pph versus need additional oxytocic versus women oxytocin group showed statistically significant lower systolic diastolic blood pressure min women carbetocin group women carbetocin group experienced metallic taste flushing headache dizziness dyspnea itching women oxytocin methergine group experienced palpitations conclusions carbetocin reasonable effective alternative syntometrine prevention pph cesarean delivery
surface potential based mathematical models among accurate physically based compact models thin film transistors turn indium gallium zinc oxide tfts available today however need iterative computations surface potential limits computational efficiency diffusion cad applications existing closed form approximations surface potential based regional approximations empirical smoothing functions could result accurate enough particular model transconductances transcapacitances work present extremely accurate range computationally efficient non iterative approximation surface potential serve basis advanced surface potential based indium gallium zinc oxide tfts models elsevier ltd rights reserved
feedback control perturbations plane poiseuille flow considered due non normal nature dynamics poiseuille flow small perturbations experience transient growth decaying zero spectrally stable regime high enough amplitudes path zero blocked exciting nonlinear effects process leads turbulence linearised navier stokes equations describe perturbations transformed finite dimensional state space representation galerkin method vortex injection boundaries devised actuation mode latter implemented peak peak control scheme appropriate set lmis allow optimised trade transient energy reduction control effort control scheme first applied linearised equations consequently integrated numerical simulations full nonlinear three dimensional navier stokes equations significant reduction transient energy growth achieved suppression transition turbulence full numerical simulations demonstrated perturbations finite initial amplitudes
gastrointestinal haemorrhage common clinical scenario using antithrombotic agents risk significantly increased management patients terms initial resuscitation well established numerous guidelines exist area however studies addressed subsequent dilemma antithrombotic agents reintroduced consequently practice variable necessarily evidenced based overall patients either anticoagulated using antiplatelet drugs secondary prophylaxis clear benefit restarting agents however limited data guide occur individuals low risk bleeding current guidelines suggest single agent aspirin continued without interruption assuming haemostatic control confirmed endoscopically higher bleeding risk aspirin withheld reintroduced early within days index endoscopy however randomised evidence lacking studies including modern agents combined anticoagulant antiplatelet regimens guidance statements limited management suggestions must extrapolated clinical trials retrospective studies data relating specifically warfarin aspirin intention review summarise evidence available lacking suggest pragmatic management options based risk benefit assessment thromboembolism recurrent bleeding
background subclinical hypothyroidism sch defined high tsh normal thyroxine data effects early substitution levothyroxine psychophysical health sch still consistent enough support introduction methods clinical parameters biochemical data quality life short form questionnaire measured intervention months euthyroid state achieved sch patients results significant reduction body weight systolic diastolic blood pressure homocysteine leukocytes neutrophils inr levels hbac fasting insulin insulin resistance measured homa index lipid parameters total cholesterol ldl cholesterol triglycerides apob ldl hdl lap apob apoa ratios tsh tabs recorded frequency fatty liver hyperlipidemia metabolic syndrome significantly decreased statistically significant positive association found average dose levothyroxine changes physical functioning vitality mental health overall dimensions mental health increasing doses levothyroxine previously listed scores grew conclusions early substitution sch improved many clinical biochemical parameters related cardiovascular risk quality life also improved correlated thyroxine doses suggesting indirect relationship degree hypothyroidism quality life
concept motor described presented first time allows convert light energy mechanical energy without need brushes power electronics original improvement made structure concerns superconducting suspension tends limit frictions ensures natural stability rotor second major novelty designed entire motor operating liquid nitrogen motor structure detailed paper including electromagnetic design electrical mechanical equations two different configurations superconducting bearings studied order make levitate rotors finally designed motors installed onboard power converted mechanical power experimental results especially speed motor consistent estimated values model
carbon nanotube cnt networks carbon fibers investigated situ sensing micro scale damage electrical resistance change due transverse matrix cracking cross ply carbon fiber reinforced cnt glass fiber reinforced hybrid composites analyzed purpose improving measurement sensitivity two different types conductively modified glass fiber epoxy nanotube composites characterized compared carbon fiber epoxy laminate two dimensional finite element models generated using electrical properties obtained experimental characterization electrostatic simulations performed investigate effect electrical anisotropy various electrode parameters measurement sensitivity matrix cracking simulation results verified cyclic loading experiments used correlate change electrical resistance transverse matrix cracks damage sensitivity electrical network highly dependent network morphology electrical anisotropy glass fiber composites nanotubes dispersed uniformly throughout polymer matrix exhibited low electrical anisotropy showed highest sensitivity matrix cracking choice electrode configuration spacing also becomes important consideration anisotropy increases carbon fiber laminates comparatively less sensitive matrix damage modification polymer matrix using carbon nanotubes provides opportunity increase damage sensitivity elsevier ltd rights reserved
recent years witnessed rapid advances use contextual information ubiquitous ambient computing information improves situated cognition awareness well stakeholders usage experience domains web next generation web made context awareness main requirement solution space software engineering domain still lacks rate adoption research introduce ontology based context aware meta model takes advantage semantic web technologies capture formalize context information providing formal context representation allows make context information integrated reusable part software engineering domain present several case studies related software evolution domain illustrate benefit sharing reusing context various software engineering tasks mentor recommendation code search result ranking elsevier inc rights reserved
objectives identify successful strategies retention participants multiyear community based randomized controlled trials rcts aiming reduce early childhood caries health disparities populations diverse racial ethnic backgrounds across diverse geographic settings methods four rcts conducted early childhood caries collaborating centers initiative national institute dental craniofacial research systematically collected information success various strategies implemented promote participant retention rct observational findings case series four rcts tabulated strategies rated study staff results participant retention months follow ranged percent percent months ranged percent across four rcts three rcts month follow retention ranged percent percent effectiveness different participant retention strategies varied widely across rcts conclusions findings case series study may help guide design future rcts maximize retention study participants yield needed data effective interventions reduce oral health disparities
wind vehicle bridge wvb system various interactions among wind vehicle bridge mechanism coupling vibration wind vehicle bridge systems explored demonstrate effects fundamental factors mean wind fluctuating wind buffeting rail irregularities light rail vehicle vibration bridge stiffness long cable stayed bridge carries light rail traffic regarded numerical example firstly finite element model built long cable stayed bridge deck generally idealized three dimensional spine beam cables modeled truss elements vehicles modeled mass spring damper systems rail irregularities wind fluctuation simulated time domain spectrum representation method aerodynamic loads vehicle bridge deck measured section model wind tunnel tests eight vertical torsional flutter derivatives bridge deck identified weighting ensemble least square method finally dynamic responses wvb system analyzed series cases results show accelerations vehicle excited fluctuating wind track irregularity great extent transverse forces wheel axles mainly depend track irregularity displacements bridge predominantly determined mean wind restricted stiffness accelerations bridge enlarged adding fluctuating wind
background myeloproliferative neoplasms mpns including classic entities polycythemia vera essential thrombocythemia primary myelofibrosis rare diseases unknown aetiology mosaicc study exploratory case control study information collected telephone questionnaires medical records methods part study patients mpn asked perceived diagnosis replies correlated haematologist diagnosis first time patient perspective mpn diagnosis classification obtained logistic regression analyses utilised evaluate role variables whether patient reported diagnosis interview adjustment variables chi square tests used investigate association mpn subtype patient reported categorisation mpn results overall patients reported diagnosis mpn recognised mpn blood condition recognised mpn cancer acknowledged mpn medical condition minimal overlap categories patients likely report disease blood condition patients significantly likely patients report condition patients single centre likely report diagnosis mpn age educational status classification effect conclusions discrepancy concepts mpn patients could result differing patient interest condition varying information conveyed treating hematologists concealment due denial financial concerns explanations differences patient perception nature disease requires larger scale investigation
extant research connecting borderline personality disorder bpd sexuality sparse current study aimed expand limited body research borderline personality traits human sexuality shed light personality features contribute specifically sexual sensation seeking sexual compulsivity sexual risk taking behaviours undergraduate students completed online questionnaire containing scales assessing bpd symptoms affective instability identity disturbance negative relationships self harm sexual sensation seeking sexual compulsivity sexual risk taking multiple linear regression analyses conducted revealed significant gender symptom interaction predictors results indicate links specific bpd symptoms specific sexuality variables total sexual compulsivity compulsive sexual control behaviours positively predicted four bpd symptoms whereas compulsive sexual violence predicted symptoms except identity disturbance sexual sensation seeking positively predicted negative relationships self harm sexual risk taking significantly predicted bpd symptoms findings improve understanding individuals borderline personality traits experience romantic sexual relationships may inform future development therapeutic interventions
effects basin hydrology hydraulic geometry channels variability incised streams investigated using available field data sets models watershed hydrology channel hydraulics yazoo river basin usa study presents hydraulic geometry relations bankfull discharge channel width mean depth cross sectional area longitudinal slope unit stream power mean velocity bankfull discharge function drainage area using simple linear regression hydraulic geometry relations developed streams classified channel evolution model cem types cem streams types iii relationships invaluable hydraulic water resources engineers hydrologists geomorphologists involved stream restoration protection relations used assist field identification bankfull stage stream dimension gauged watersheds well estimation comparative stability stream channel set hydraulic geometry relations presented study empirical relations describe physical correlations stable incised channels cross sectional area combines effects channel width mean channel depth found highly responsive changes drainage area bankfull discharge analyses cross sectional area channel width mean channel depth mean velocity conjunction changes drainage area bankfull discharge indicated channel width much responsive changes drainage area bankfull discharge mean channel depth mean velocity international research training centre erosion sedimentation world association sedimentation erosion research published elsevier rights reserved
article describe history current state psychosomatic medicine psm japan propose measures could considered based view future prospects psm japan japanese society psm jspm established first department psychosomatic internal medicine japan established kyushu university psm japan shown prominent unique development members march comprised medical doctors including psychosomatic internal medicine pim specialists general internists psychiatrists pediatricians obstetricians gynecologists dentists dermatologists others non physician members include psychology nursing staff specialists japanese society psychosomatic internal medicine jspim founded another major society physicians mainly composed internists first joint congress five major psm societies field held included japanese society psychosomatic medicine psychosomatic obstetrics gynecology psychosomatic pediatric medicine psychosomatic dental medicine psychosomatic internal medicine several subdivided societies related medical fields also established cardiovascular digestive dermatological oriental medicine eating disorders pain fibromyalgia stress science behavioral medicine psycho oncology jspm jspim participate international activities including publishing biopsychosocial medicine bpsm establishment sister society relationship germany college psm psm japan adopted variety professional psychotherapies including transactional analysis autogenic therapy cognitive behavioral therapy mutual interrelationship promoted japanese union associations psycho medical therapy upm although psm japan functioning high level remain areas could improved among medical schools japan eight university hospitals independent department psm dental schools three dental university hospitals department psychosomatic dentistry accumulation evidence regarding mind body relationship clinical basic science based latest advanced technology necessary psychosomatic medicine community needs make even greater contribution meeting needs modern society possibilities future development psm japan must widely discussed
paper presents study multi objective optimal design sliding mode control actuated nonlinear system parallel simple cell mapping method multi objective optimal design sliding mode control involves six design parameters five objective functions parallel simple cell mapping method finds pareto set pareto front efficiently parallel computing done graphics processing unit numerical simulations experiments done rotary flexible arm system results show proposed multi objective designs quite effective
promising development design datacenters hybrid network architecture consisting optical electrical elements context joint problem bandwidth allocation placement problem recently received attention electrical datacenter networks poses new different challenges addressed yet hybrid datacenters particular foresee two issues number edge switches simultaneously reached using optical paths edge switch limited switch size dynamic creation optical paths potentially establish constrained optical network topology leading poor performance abstract requests tenants virtual networks study problem embedding virtual networks hybrid datacenter translates joint problem bandwidth allocation placement topology constraints virtual networks satisfied develop analyse two algorithms embedding dynamically arriving virtual network demands hybrid optical electrical datacenter simulations demonstrate effectiveness exploiting already established optical paths also using electrical network embedding requests virtual networks
previous research demonstrated athletes displaying dominant nonverbal behavior nvb perceived possess favorable performance characteristics expected perform better athletes showing submissive nvb present study used point light videos baseball pitcher displaying dominant submissive neutral nvbs show effect mainly driven submissive condition difference neutral dominant condition evident suggesting important avoid displaying submissive nvb instead showing dominant nvb neutral nvb already seems lead impression athlete handle situation results show nvbs expressing dominance submissiveness important early cues affect impression formation process sport expectancy success athlete observing nvb addition results indicate information ability level athlete might diminish effect performance consequences effect nvb discussed
given high order large scale tensor decompose latent factors process commodity computers limited memory questions closely related recommender systems modeled rating data matrix tensor utilize contextual information time location increase order requires tensor factorization methods scalable order size tensor paper propose two distributed tensor factorization methods cdtf sals methods scalable aspects data show trade convergence speed memory requirements cdtf based coordinate descent updates one parameter time sals generalizes number parameters updated time experiments methods factorized five order tensor billion observable entries mode length rank state art methods failed moreover methods required several orders magnitude less memory competitors implemented methods mapreduce two widely applicable optimization techniques local disk caching greedy row assignment speeded methods also competitors
humans almost physiological behavioural functions occur rhythmic basis therefore possibility delays advances desynchronizations circadian rhythms may play role pathophysiology psychiatric disorders interesting field research particular mood disorders seasonal affective disorder major depression linked circadian rhythms alterations furthermore antidepressant efficacy pharmacological non pharmacological strategies affecting endogenous circadian rhythms new antidepressant medications light therapy sleep deprivation consistent idea circadian alterations may represent core component depression least subgroup depressed patients paper briefly describes molecular genetic mechanisms regulating endogenous clock system reviews literature supporting relationships depression antidepressant treatments changes circadian rhythms elsevier inc rights reserved
water stress major cause tree mortality response drought leaves wilt due increase petiole flexibility present analytical model coupling petiole mechanics thermal balance xylem hydraulics investigate role petiole flexibility protecting tree water stress model suggests turgidity dependent petiole flexibility significantly attenuate minimal xylem pressure thus reduce risk cavitation moreover show petiole flexibility increases water use efficiency trees water stress elsevier ltd rights reserved
commodity operating system kernels vulnerable wide range attacks due large code base broad attack surface mitigation mechanisms code signing circle plus code integrity protection raised bar kernel security turn attack mechanisms also become increasingly advanced evolved simple injection malicious code sophisticated code reuse attacks return oriented programming rop study authors describe exception oriented programming eop novel code reuse method construct kernel malware unlike previous rop reuse limited part existing code gadgets eop able reuse instruction existing code chain instructions order generate malicious programmes result eop provide attackers powerful capabilities less complexity building kernel malware
present model fast evaluation total drag ship hulls operating wet dry transom stern conditions calm wavy water based combination unsteady semi lagrangian potential flow formulation fully nonlinear free surface treatment experimental correlations simplified viscous drag modeling implementation entirely based open source libraries spatial discretization solved using streamline upwind petrov galerkin stabilization iso parametric collocation based boundary element method implemented using open source library deal resulting nonlinear differential algebraic system integrated time using implicit backward differentiation formulas implemented open source library sundials open cascade library used interface model directly computer aided design data structures model accounts automatically hulls transom stern wet dry regimes using specific treatment free surface nodes stern edge automatically detects hull advances low speeds case transom stern partially immersed pressure patch applied water surface detaching transom stern recover gravity effect recirculating water underlying irrotational flow domain parameters model used impose pressure patch approximated experimental relations found literature test cases considered navy combatant dtmb national physical laboratory hull comparisons experimental data quasi steady test cases water elevation total hull drag presented discussed quality results obtained quasi steady simulations suggests model represent promising alternative current unsteady solvers simulations froude numbers
background community acquired methicillin resistant staphylococcus aureus methicillin sensitive aureus infections common south western alaska associated traditional steambaths decade ago recommendations made affected communities included preventive skin care cleaning methods steambath surfaces use protective barriers steambaths reduce risk aureus infection objective review community medical data suggested number skin infection clinical encounters increased steadily last years designed public health investigation seek root causes study design using mixed methods approach person surveys convenience sample rural communities assessed range knowledge attitudes practices concerning skin infections skin infection education messaging prevention activities home self care skin infections results described barriers implementing previous recommendations evaluated acceptability potential interventions prior public health messages appear effective reaching community members appear understood accepted found major misconceptions regarding boil someone got one overall respondents seemed concerned boils health problem reported motivated prevent boils identified current practices used avoid skin infections disinfection steambaths also identified barriers engaging protective behaviours lack access laundry facilities conclusions findings used help guide public health strategic planning identify appropriate evidence based interventions tailored specific needs region
background evidence effectiveness cognitive behaviour therapy cbt robust national organizations united kingdom united states recommend use utilized full potential low middle income countries adaptation cbt treatment target culture may facilitate uptake study explored views patients schizophrenia caregivers mental health professionals purpose cultural adaptation cbt method project conducted teaching hospital china systematic content question analysis techniques used analyse data generated series qualitative interviews china identification emerging themes categories compared contrasted themes across different interviews recursively triangulation themes concepts undertaken compare contrast data different participating groups results work highlighted barriers therapy well opportunities use cbt environment patients carers china use bio psycho spiritual social model illness cbt commonly used help schizophrenia china conclusions study facilitate therapists using cbt people psychosis china results require tested clinical trials
background time lapse microscopy essential tool capturing correlating bacterial morphology gene expression dynamics single cell resolution however state art computational methods limited terms complexity cell movies analyze lack automation proposed bacterial image analysis driven single cell analytics basca computational pipeline addresses limitations thus enabling high throughput systems microbiology results basca segment track multiple bacterial colonies single cells grow divide time cell segmentation lineage tree construction give rise dense communities thousands interacting cells field view combines advanced image processing machine learning methods deliver accurate bacterial cell segmentation tracking measure even processing images imperfect quality several overcrowded colonies field view addition basca extracts fly plethora single cell properties get organized database summarizing analysis cell movie present alternative ways analyze visually explore spatiotemporal evolution single cell properties order understand trends epigenetic effects across cell generations robustness basca demonstrated across different imaging modalities microscopy types conclusions basca used analyze accurately efficiently cell movies high resolution single cell level large scale communities many dense colonies needed shed light bacterial community effects epigenetic information transfer play role important phenomena human health biofilm formation persisters emergence etc moreover enables studying role single cell stochasticity without losing sight community effects may drive
shielding effectiveness estimation enclosure apertures attractive issue electromagnetic compatibility emc research area though many fast algorithms developed calculation mainly focus case single cavity moreover methods neglect wave coupling apertures enclosure outside fast algorithm based electromagnetic topology proposed calculating cascading multiple enclosures apertures algorithm wave coupling apertures directions taken consideration firstly equivalent circuital model cascading double enclosures signal flow graph electromagnetic topology given followed derivation scattering matrix apertures node propagation relationships tube level reflection relationships node level derived result general blt baum liu tesche equation voltage calculation node established two major categories cascading three enclosures apertures investigated serially cascading three enclosures general blt equations extended basis blt equations cascading double enclosures since structures simple extension hybrid serially parallelly cascading three enclosures common walls main enclosure two sub enclosures considered topological node represented three port network whose scattering matrix derived according definition scattering parameters consequently general blt equations hybrid serially parallelly cascading three enclosures developed compared algorithms presented relevant literature topology based algorithm proposed paper calculate shielding effectiveness cascading multiple enclosures also lead accurate results impedance apertures obtained using diaphragms model order validate proposed method cascading double enclosures literature chosen example calculated results good agreement literature three enclosures different configurations dimensions also designed validate proposed method results proposed method compared finite difference time domain fdtd method found good agreement experimental results also demonstrate validation proposed method especially proposed method takes far less time calculate fdtd method
based static dynamic compression tests plain concrete sio concrete caco concrete composite concrete different contents dynamics performance nano concrete materials analyzed study influence factors find optimum nano content
background menopause associated increased risk cardiovascular disease causal factors proposed loss estrogen subsequent alterations hormonal milieu however factors contribute deterioration cardiometabolic health postmenopausal women debated menopausal transition also associated increased age fat mass furthermore indications reduced cardiometabolic adaptations exercise postmenopausal women add adverse health profile objective sought evaluate risk factors type diabetes cardiovascular disease late premenopausal early postmenopausal women matched age body composition investigate effect high intensity training study design month high intensity aerobic training intervention involving healthy nonobese late premenopausal early postmenopausal women conducted anthropometrics body composition blood pressure lipid profile glucose tolerance maximal oxygen consumption determined baseline intervention results baseline groups matched anthropometrics body composition differed years age mean confidence limits years time since last menstrual period postmenopausal women mean confidence limits years hormonal levels estrogen follicle stimulation hormone luteinizing hormone confirmed menopausal status baseline postmenopausal women higher total cholesterol low density lipoprotein cholesterol high density lipoprotein cholesterol premenopausal women training intervention reduced body weight waist circumference improved body composition increasing lean body mass decreasing fat mass similarly groups moreover training resulted lower diastolic blood pressure resting heart rate total cholesterol low density lipoprotein cholesterol total cholesterol high density lipoprotein cholesterol index improved plasma insulin concentration oral glucose tolerance test groups conclusion cardiovascular risk factors similar late premenopausal early postmenopausal women matched age body composition exception postmenopausal women higher high low density lipoprotein cholesterol levels month intervention high intensity aerobic training reduces risk factors type diabetes cardiovascular disease similar extent late premenopausal early postmenopausal women
deja nebulous memory experience defined clash evaluations familiarity novelty stimulus sought generate laboratory pairing drm recognition task generates erroneous familiarity critical words monitoring task participants realise erroneously familiar words fact novel tested participants experiment varied participant awareness stimulus novelty erroneous familiarity strength found deja reports frequent high novelty critical words similar low novelty critical words yielding baseline levels deja report frequency similar significant variation deja report frequency according familiarity strength discursive accounts experimentally generated deja experience suggest aspects naturalistic deja experience captured analogue analogue also limited focus prone influence demand characteristics discuss theoretical methodological considerations relevant development procedure propose verifiable novelty important component naturalistic experimental analogues deja
study various problems elimination game unity technology advantages convenient interactive graphical development environment cross platform features scripting language simple safety efficient paper carefully investigated described candy elimination categories mobile android game algorithm design design game development process achieve level game options multiple candy elimination special effects scores statistics functions development games games certain guidance reference
agricultural water scarcity major limiting factor crop production dry land regions sub saharan africa ssa despite notable efforts developing macro catchment rainwater harvesting rwh techniques studies evaluated performance rwh deficit supplemental irrigation crops examine agro meteorological risks late onset early cessation overall low rainfall amounts long dry spells growing season evaluate potential macro catchment rwh supplemental irrigation onion southern dry lands ethiopia field experiments undertaken evaluate effects etc etc etc irrigation levels yield water productivity onion dry wet seasons harvestable yield water productivity onion etc irrigation significantly lower etc irrigation dry wet seasons thus deficit supplemental irrigation onion etc implemented macro catchment rwh reduce risks crop failure significant yield declines dryland areas elsevier rights reserved
basis submitted study continuously rising demands alter curricula aim develop students key competences order increase professional versatility lack scientific research discussions show little investigation done issue development key competences therefore primary objective study present teaching methodology process creating educational model pilot verification aimed development key competences interactive whiteboard subject technology partial results pilot research conducted research sample grade students primary schools slovakia show usefulness especially development teamwork terms interpersonal competences problem solving terms learning competences reading comprehension terms communication competences presented educational model reflects contemporary requirements terms using information communication technologies teaching subject technology acquisition key competences becomes considerably important
study sought explore relationships depression anxiety stress non suicidal self injury nssi mediating roles rumination emotion regulation relationship sample comprised australian university students completed self report questionnaire assessing relevant variables sample engaged nssi weeks prior survey depression anxiety stress exerted direct effect nssi relationship mediated cognitive reappraisal relationship stress nssi also mediated expressive suppression results imply intervention efforts aimed teaching adaptive emotion regulation strategies students experiencing high levels psychological distress may reduce frequency nssi
article proposed estimation method young modulus carotid artery evaluate progressiveness arteriosclerosis carotid artery surrounding tissues modeled compound cylinder model view point strength materials model gives amount theoretical displacement carotid artery surrounding tissues diastolic phase systolic phase young modulus carotid artery one model parameters obtained fitting theoretical displacement measurement value precisely shown young modules estimated propose method agrees measured literatures
objective manual evaluation machine learning algorithms selection suitable classifier list available candidate classifiers highly time consuming challenging task selection carefully accurately done resulting classification model able produce expected performance results study present accurate multi criteria decision making methodology amd empirically evaluates ranks classifiers allow end users experts choose top ranked classifier applications learn build classification models methods material existing classifiers performance analysis recommendation methodologies lack appropriate method suitable evaluation criteria selection relative consistent weighting mechanism fitness assessment classifiers performances satisfaction various constraints analysis process assist machine learning practitioners selection suitable classifier amd methodology proposed presents expert group based criteria selection method relative consistent weighting scheme new ranking method called optimum performance ranking criteria based multiple evaluation metrics statistical significance fitness assessment functions implicit explicit constraints satisfaction time analysis ranking classifiers performance proposed ranking method integrates wgt avg score cputimetesting cputimetraining consistency measures using technique order performance similarity ideal solution topsis final relative closeness score produced topsis ranked practitioners select best performance top ranked classifier problems hand findings based extensive experiments performed publically available uci openml datasets using classification algorithms heterogeneous families classifiers average spear man rank correlation coefficient observed similarly amd method showed improved performance average spearman rank correlation coefficient compared correlation coefficient state art ranking methods performance algorithms pag adjusted ratio ratio arr conclusion implication evaluation empirical analysis results comparison state art methods demonstrate feasibility amd methodology especially selection weighting right evaluation criteria accurate ranking selection optimum performance classifier user application data hand amd reduces expert time efforts improves system performance designing suitable classifier recommended amd methodology elsevier ltd rights reserved
composites made fromrenewable sources become important alternative materials designing manufacturing engineering industrial products natural fiber composites become superior materials compared conventional fiber composites due easy manufacturing process high fiber content reduction polluting base content lightweight incineration environmental cleanliness increasing concern look sustainable alternative materials replace conventional materials used natural fibers constitute good alternative reinforcement material since readily available fibrous form extracted low costs present study environment friendly green composites prepared mechanical properties composites evaluated results indicated significant improvement tensile flexural impact properties hybrid composites effect hybridization reduces environmental effects internal structure broken surface delamination fibers failure morphology analyzed using scanning electron microscopy analysis
chemokine motif ligand cxcl also named fractalkine fkn implicated psychiatric disorders functions novel adipocytokine however attention paid role fkn anorexia nervosa current study performed explore fkn levels determine role involvement total girls aged years healthy controls simple obesity enrolled cross sectional study blood samples collected fasting state serum fkn concentrations determined using elisa skinfold thickness tsf biceps triceps well mid arm muscle circumference mamc used determine nutritional status results showed serum fkn levels significantly lower group control groups adjusting body mass index bmi fkn concentrations group statistically higher groups significant correlations serum fkn body weight bmi cole index serum insulin observed addition serum fkn levels positively related tsf mamc subjects serum fkn concentrations attenuated girls compared healthy adolescents positively related nutritional status lower fkn levels may regulated nutrition status response starvation adjusting bmi higher fkn levels may reflect persistent inflammation present patients
background atopic diseases including asthma exacerbate type immune responses involve number immune cell types including regulatory treg cells emerging type innate lymphoid cells ilcs although ilcs potent producers type cytokines regulation ilc activation function well understood objective present study first time evaluate treg cells interact pulmonary ilcs control function methods ilcs treg cells evaluated using vitro suppression assays cell contact assays gene expression panels also human ilcs treg cells adoptively transferred nod scid gamma deficient mice given isotype anti inducible cell costimulator ligand icosl antibodies challenged assessed airway hyperreactivity results show induced treg cells natural treg cells effectively suppress production ilc driven proinflammatory cytokines vitro vivo mechanistically data reveal necessity inducible cell costimulator icos icos ligand cell contact treg cell mediated ilc suppression alongside suppressive cytokines tgf beta using translational approach demonstrate human induced treg cells suppress syngeneic human ilcs icosl control airway inflammation humanized ilc mouse model conclusion findings suggest peripheral expansion induced treg cells serve promising therapeutic target ilc dependent asthma
two separate geotextile bag systems evaluated means capturing dewatering bio solids effluent stream recirculating aquaculture systems ras geotextile bag system used high molecular weight cationic polyacrylamide pam polymer flocculant aid two systems operated freshwater brackish water conditions complete analysis including water quality agronomic sludge analysis conducted north carolina state university fish barn large scale freshwater ras demonstration growout facility evaluation water quality performance similar geotextile bag system also conducted marine aquaculture research center near marshallberg north carolina usa brackish conditions ppt results indicated performance systems similar tss cod removal greater respectively systems analysis sludge collected freshwater system days dewatering inactive mode showed moisture content dry matter indicating system effective passively dewatering bio solids nutrient removal efficiency may system specific based geotextile bag size influent flow rate geotextile bag systems using flocculant aids efficient means capturing dewatering waste solids ras effluents optimized geotextile bag system designs depend flow rate feed rate solids dewatering time fate treated effluent evaluation aid predicting expected performance determining appropriate size geotextile bag system type treatment required downstream geotextile bag system used solids capture ras wastewater treatment system depend intended fate treated effluent elsevier rights reserved
past human machine interfacing hmi motivated many studies develop systems devices able transfer analog commands user body machines however many design solutions still affected comfort performance limitations due wire communications long calibration procedures resistance hand motions power supplies requiring cables batteries goldfinger hmi glove introduced paper potential overcome limitations thanks integration advanced materials miniaturization components electronics power generation biomechanical energy harvesting hand motions used communicate machine via led tracking system information digitalized dedicated software also provides machine microcontroller programming language additionally battery discharge time reduced due power harvested integrated piezoelectric transducers generate power finger motions
background nursing education programs every state must meet specified nclex pass rate standards order maintain licensure accreditation standards source great anxiety educators students wide variety pass rate standards among states addition individual nursing program pass rates vary substantially one year next objectives pass rate variation suggests need scrutiny accuracy applying state pass rates standard evaluating nursing education program study considers implications variation design study computes confidence intervals nursing program pass rates determine whether programs failed meet pass rate standards may done accident whether programs met pass rate standards may done accident data study data includes statutes regulations establish pass rate standards nclex pass rates nursing programs reflected reports provided state nursing boards findings almost nursing education programs violated state pass rate standard least among programs failed meet pass rate standards confidence interval extended pass rate standard determination programs meet pass rate standards could well erroneous approximately programs met pass rate standards confidence intervals went pass rate standard finding programs complied state pass rate standards might also erroneous conclusions application confidence intervals nursing program pass rates suggests use pass rate standards evaluate nursing program quality may appropriate suggests need rethink application state pass rate standards evaluating nursing education programs elsevier ltd rights reserved
aim aims study determine whether serum levels precursor brain derived neurotrophic factor probdnf mature bdnf mbdnf matrix metalloproteinase mmp altered patients eating disorders including anorexia nervosa bulimia nervosa explore whether levels associated decision making abilities methods nineteen women women age matched healthy control women enrolled current study participants decision making abilities assessed using iowa gambling task igt eating related pathophysiology depressive anxiety symptoms also evaluated results mmp level significantly lower either serum levels probdnf mbdnf differ among three groups investigation serum levels probdnf mmp patients controls revealed significant correlation positive correlations mbdnf level igt performance also mmp level igt performance correlations occur mmp level positively associated symptom scale one subscales bulimic investigatory test edinburgh conclusion results suggest serum level mmp plays role pathophysiology serum levels mbdnf mmp may associated decision making abilities patients
breast cancer brca gene makes great contributions repair dna association brca polymorphism cancer risk investigated growing number studies conclusions conclusive obtain comprehensive conclusion performed meta analysis studies cases controls pooled results indicated brca gene variant decreased risk overall cancer homozygous model odds ratio confidence interval recessive model stratified analysis observed decreased risk associated brca subgroups among asians high score studies caucasians low score studies conclusion despite several limitations meta analysis suggested brca genetic variation may associated decreased susceptibility cancer
paper presents graphical block diagram based programming tool new software development system digital signal processing dsp system provides block diagram editor therefore dsp system easily built connecting functional blocks described signal flow graph block library set includes basic signal processing functions frequently used high level signal processing functions like fir iir fft etc friendly graphic user interface gui based window system developed support design step users improve design easily according gui response guarantee correctness circuits designed debugging verifying capabilities embedded system full system combined structural silicon compiler developed previously several designs illustrated examples shown tool suitable dsp system design using silicon compiler
humans connection sleep mood long recognized although direct molecular evidence lacking identified two rare variants circadian clock gene period per humans familial advanced sleep phase accompanied higher beck depression inventory seasonality scores hper transgenic mice showed altered circadian period constant light exhibited phase shifts sleep wake cycle short light period photoperiod paradigm molecular characterization revealed rare variants destabilized per failed stabilize period proteins play critical roles circadian timing although hper mice showed mild depression like phenotype per knockout mice demonstrated consistent depression like behavior particularly studied short photoperiod supporting possible role per mood regulation findings suggest per may nexus sleep mood regulation fine tuning processes adapt seasonal changes
community based studies consistently shown sex ratio heavily skewed towards males autism spectrum disorders asd factors underlying predominance males largely unknown way girls score standardized categorical diagnostic tools might account underrecognition asd girls despite existence different norms boys girls asd several major screening tests algorithm autism diagnosis interview revised adi reformulated aim study investigate adi items discriminate males females evaluate weighting final diagnosis autism conducted discriminant analysis sample probands including females asd recruited paris autism research international sibpair paris study replication analysis run independent sample probands including females asd recruited autism genetics resource exchange agre program entering raw scores adi items independent variables correctly classified males females paris cohort males females agre cohort among items extracted stepwise four belonged adi algorithm used final diagnosis asd conclusion several items adi taken account diagnosis autism significantly differentiates males females potential gender bias thus induced may participate underestimation prevalence asd females autism res international society autism research wiley periodicals inc autism res international society autism research wiley periodicals inc
new algorithm priority search created help skip list data structure algorithms skip list data structure consists linked lists formed layers linked pyramidal way time complexity searching algorithm equal lgn element skip list data structure new developed searching algorithm based hit search number searched data datum greater hit search number upgraded skip list data structure upper level mostly searched data located upper levels skip list data structure rarely searched data located lower levels skip list data structure pyramidal structure data constructed using hit search numbers another word frequency data thus time complexity searching almost theta records data set paper applications searching algorithms like linear search binary search priority search realized obtained results compared results demonstrated priority search algorithm better binary search algorithm
current sources howland topology made operational amplifier often used sensors requires constant current polarization bioimpedance measuring actuators driving systems theoretical determination overall performances circuits generally known paper presents practical method real output impedance determining current sources based performing two simple measurements results according measurements practical circuit using circuit frequency cut khz using one circuit ths cut frequency mhz
paper presents novel diagnosis method based error voltage gbts open circuit faults dual loop controlled voltage source inverters phase voltage changes open circuit faults occur error voltages phase calculated directly control algorithm phase voltages corresponding flexible references available main control system therefore proposed diagnosis method requires additional sensors electrical circuits detect open circuit faults features fast diagnostic time suitable various load conditions strong robustness false alarms easily inserted existing control algorithms subroutine experimental results carried show effectiveness proposed method
inspired biological immune system outside invasion nature paper propose network security strategy using agent technology agents independent behavior capacity set resisting network intrusion using spontaneous coordinate organization based comparisons existing immunization strategies target immune acquaintance immune random immunity found importance nodes network influenced interaction nodes degree nodes information flow factors nodes important greater influence whole network important nodes infected virus higher probability spreading hazard information therefore paper proposes network security model using agent technology important nodes implanted relationship immunization strategy experimental results show network suffered random malicious attacks relationship immunization strategy effective others existing methods
background patients atopic dermatitis predisposition staphylococcus aureus herpes simplex virus infection treatment atopic diseases steroid immunosuppressive agents induces opportunistic infection however concern regarding visual prognosis patients atopic keratoconjunctivitis akc complicated infectious keratitis report unusual case atopic shield ulcer kocuria keratitis case presentation year old japanese man presented day history eye pain visual loss left eye initial examination shield ulcer observed upper central cornea left eye conjunctiva eyes velvety appearance due papillary formation well hyperemia swelling palpebral area shield ulcer showed white stromal opacification marginal zone coral like appearance samples obtained corneal scraping kocuria identified microbiological examination including culture matrix assisted laser desorption ionization time flight mass spectrometry rrna gene sequence analysis performed using isolated kocuria strain patient obtained dna sequence showed homology kocuria koreensis combination corneal scraping instillation cefmenoxime antibiotic ophthalmic solution considered useful treatment kocuria keratitis conclusion clinicians aware kocuria keratitis corneal complication akc rapid diagnosis kocuria keratitis may improve visual prognosis
recent research concludes prevention alcohol exposed pregnancies aep must occur preconceptional women either reducing alcohol consumption women risk planning pregnancy preventing pregnancy women drinking risky levels one aep prevention program currently underway non pregnant american indian women oglala sioux tribe ost changing high risk alcohol use increasing contraception effectiveness study choices program ost choices program shows promise lowering aep risk american indian women natural next step evaluate potential impact social support encouraging behavioral changes focus groups community members key informant interviews health social service professionals completed uncover interpret interrelated themes conventional content analysis methodology used eight focus groups held american indian participants including adult women child bearing age elder women adult men key informant interviews completed health social service professionals based input focus groups key informant interviews several subthemes regarding social support prevention aep stood including role family especially elders impact community important function culture study highlighted important influence social support aep prevention especially among american indian population social support cultural historical significance
complete model thermionic generator developed order optimise technology application solar thermal generation electricity steady state current densities predicted model shown agree published experimental thermionic data two separate genetic algorithm optimisations carried power density efficiency electrode temperatures work functions external circuit resistance electrode separation varied result optimisations two configurations separately exhibiting maximum power density maximum efficiency parameter ranges applicable concentrating solar thermal power examination optimum simulation parameters indicated future developments lowering collector work functions increasing emitter service temperature decreasing attainable electrode separations positively impact device performance elsevier ltd rights reserved
commercial anti virus software traditionally memorizes specific byte sequences known signatures file contents previously encountered malware however malware authors evade signature based detection many ways instance using obfuscation techniques packing encryption compression hide snippets malicious code writing metamorphic malware tampering existing malware hypothesize certain evasion techniques leave traces file entropy signal revealing either similarities known malware presence tampering per end present suspend suspicious entropy signal detector expert system evaluates suspiciousness executable file entropy signal order subserve malware classification whereas traditionally entropy analysis used goal packer detection therefore entropy based features often merely comprise mean entropy entropy file subcomponents suspend applies non stationary time series modeling aid malware detection particular suspend quantifies amount structure entropy signal detrended fluctuation analysis finds location size sudden jumps entropy mean change point modeling computes distribution entropic variation across multiple spatial scales wavelet decomposition addition suspend summarizes entropy signal empirical probability distribution suspend run time made scale linearly file size well suited large scale malware analysis apply suspend large scale malware detection task heterogeneous real world samples million features find suspend boosts predictive performance traditional entropy analysis found packer detectors moreover suspend focus entropy signals makes natural candidate combining types features instance combining suspend strings based feature set boosts predictive accuracy thus whereas traditionally entropy analysis focused detecting file packed suspend comprehensive representation entropy signal helps determine file malicious illustrate application suspend studying pieces virransom family viral ransomware could cost millions large organizations suspend able detect studied files confidence whereas traditional strings based model close undecided represents entire family single string elsevier ltd rights reserved
complete binary tree important network structure long investigated parallel distributed computing many nice properties used embedded interconnection architectures mobius cube important variant hypercube many better properties number edges vertices paper prove complete binary tree vertices embedded dilation congestion load expansion tending elsevier inc rights reserved
since birth clickers pennsylvania state university numerous arguments effectiveness study aiming review use clickers education examined literature around decade use clickers involving benefits defects use clickers peer discussion use clickers learning teaching problem solving effectiveness use clickers among non students besides relationships lecturing learning aided clickers current developments use clickers also reviewed discussed concluded clickers one form modern technology gained growing popularity due advantages peer discussion anonymity instant feedback although disputes still remained studies clickers new technologies still needed push forward levels education cross disciplinary cooperation computers education psychology may needed design advanced educational technologies
objectives opportunities innovate skin care product certainly many opportunities many technologies involved work assumed role identifying categorizing opportunities develop comprehensive intelligible classification system could used tool support decision making different professional contexts methods initially employed delphi method identify discuss standardize opportunities innovate skin care product finally used classification system obtained previous phase label patent applications therefore testing suitability utility system results end process achieved category classification system opportunities innovate skin care products also illustrated system could used conclusion resultant classification system offers normalized terminology cosmetic scientists interested dealing particularities incremental radical innovations skin care products
objective investigate feasibility safety skin skin care birth moderately preterm infants design prospective cohort study setting study conducted maternity wards nicus three study sites norway participants ninety preterm infants born vaginally gestational ages weeks days weeks days methods comparison groups preterm infants received skin skin care conventional treatment incubators birth results median gestational age birth weight similar two groups weeks days versus weeks days versus differences first body temperature blood glucose level groups conclusion early skin skin contact delivery room moderately preterm infants may feasible safe
vertebral osteomyelitis known occur chronic granulomatous disease phagocytic disorder etiology usually fungus indolent spread fungal infection lungs adjacent ribs vertebra often results persistent pneumonia vertebral deformities report year old boy chronic cough kyphosis fungal vertebral osteomyelitis acinetobacter spp paravertebral soft tissue infection related linked chronic granulomatous disease
study investigated association mindfulness racial socialization messages approach oriented coping strategies among african americans three hundred african american college students completed measures mindfulness racial socialization coping strategy preference results revealed higher degree mindfulness culturally based racial socialization messages positively associated planning active coping strategies study also found mindful observation positively related minority culturally based racial socialization messages research discovered racial socialization messages related mindfulness suggesting two metacognitive self regulatory strategies promote adaptive coping strategy selection potentially buffer negative consequences stressors african americans stress reduction programs promote cultural pride reinforcement well mindfulness techniques may ideal african americans grappling race related stressors
method makes possible increase precision coordinates user differential mode operation satellite radio navigation system determined considered increased precision achieved separate introduction corrections predicted coordinates satellite results navigation measurements
electrical methodology developed monitor crack advance ballistic impact velocities radial cracks measured information development crack pattern obtained done via grid thin gold tracks printed onto front back surfaces sample elements incorporated electrical circuit high speed data acquisition carried impact fracture behaviour two grades alumina examined hard spherical projectiles used range impact velocities increase radial crack velocity detected increasing impact velocity within range differences crack velocities also noted two types alumina crack speed values good agreement data reported previously similar systems obtained using high speed photography methodology proposed looks reliable convenient economically attractive elsevier ltd rights reserved
although species traits potential disentangle long term effects multiple potentially confounded drivers ecosystems issue received little attention literature aimed filling gap assessing relative effects hydroclimatic water quality factors trait composition invertebrate assemblages years middle loire river france using priori predictions long term variation trait based adaptations three decades evaluated ability invertebrate traits indicate effects warming discharge reduction water quality improvement hydroclimatic water quality factors contributed variation trait composition initial trait response predictions made according observed long term hydroclimatic changes confirmed supported general climate induced trend involving adapted resistance resilience strategies partial confounding effect water quality improvement acting trophic processes also highlighted indicating improved water quality management significantly help reduce adverse effects climate change trait based approach wider implications investigating long term changes driven multiple potentially confounded factors frequently encountered context global change
near infrared nir imaging method required diagnosis varicose veins mean veins become enlarged twisted leg cases hair leg could dense formed noise nir vein images preliminary treatment filter effect hair nir image carried filter design based optical angular spectrum theory select threshold spatial frequency order separate specific vein infrared image leg hair experimental setup combined nir light charge coupled device camera filtering algorithms implemented prove effectiveness hair noise removal results demonstrated annulus butterworth filter effective reduce hair noise simultaneously enhance contrast venous images leg others design processed nir image terms optical angular spectrum theory thereby optical treatment contrast enhancement veins image possible future
purpose autosomal dominant hyper ige syndrome hies rare complicated primary immunodeficiency disease pid signal transducer activator transcription stat gene mutation found cause hies distribution hies patients stat deficiency chinese population clear herein retrospectively report hies patients stat deficiency demonstrate clinical immunological genetic features methods patients clinical data collected medical records routine laboratory testing results included lymphocyte subset analysis immunoglobulin quantification stat mutations investigated sequencing genomic dna results among patients pid clinically diagnosed hies among confirmed stat mutant hies ratio male female patients patients nih scores points mean ages onset diagnosis years respectively three patients died mean age years eczema recurrent skin infection respiratory tract infection common clinical symptoms present patients study six patients suffered complication bcg vaccination noninfection symptoms characteristic facial features patients retention primary teeth patients abnormal bone fractures patients eleven types stat mutations identified patients including novel mutation conclusions retrospectively report largest chinese cohort hies patients stat mutation unique features compared existing literature reports include later age diagnosis significantly higher rate bcg complications lower rate candidiasis chronic otitis media
objective recent studies found correlation television viewing behavior problems children study aimed examine extent children television viewing time correlation behavioral problems preschool age general population sample method total preparatory school students aged years recruited study questionnaires children time spent watching television socioeconomic status family ses child behavior checklist cbcl administered parents children results overall mean daily television viewing time hours elevated scores somatic complaints depression anxiety social problems thought problems attention problems aggressive behaviors internalization externalization subscales total problems associated higher television watching times overall television viewing time positive correlation social problem somatic complaints problem anxious depressed problem internalization externalization total problem scores conclusion television viewing time positively associated internalization externalization total problems using cbcl preschool children although study suggest time viewing television one important determinants children behavior problems indicates heavy viewing may risk behavioral problems children findings support importance parental monitoring children television watching habits
objective visual quality assessment models fundamental issue computer graphics quality assessment metrics may allow wide range processes guided evaluated level detail creation compression filtering computer graphics assets composed geometric surfaces several texture images mapped make rendering realistic quality assessment metrics exist geometric surfaces almost research conducted evaluation texture mapped models context present new subjective study evaluate perceptual quality textured meshes based paired comparison protocol introduce texture geometry distortions set reference models produce database distorted models evaluated using two rendering protocols based analysis results propose two new metrics visual quality assessment textured mesh optimized linear combinations accurate geometry texture quality measurements proposed perceptual metrics outperform counterparts terms correlation human opinion database along associated subjective scores made publicly available online
gap yield potential average farmers yield measures capacity yield improvement current technology north china plain ncp major maize producing region china improving maize yield ncp essential food security country previous studies found substantial maize yield gap region similar average yields whereas others reported much smaller gaps study used remote sensing estimated yield resolution quantify county level yield distributions used distributions calculate yield gaps persistence level yield counties ncp average yield across county years averaged county level yield gap measured difference top percentile yields average yield county average yield measured difference maximum average yields county estimated gap increased average also evaluated persistence level farmers yield performance indicator much gap might reduced propagating agronomic practices highest yielding farmers average yield gap persistence average yield gap average yield range across counties distance major rivers identified one factor significant effect yield nevertheless tremendous spatial heterogeneity yield persistence level across ncp analysis within individual counties required better prioritize means shrink yield gap elsevier rights reserved
vision internet things iot foresees future internet incorporating smart physical objects offer hosted functionality iot services services integrated traditional enterprise level services form creation ambient intelligence wide range applications facilitate seamless access service life cycle management large distributed heterogeneous iot resources service oriented computing resource oriented approaches widely used promising technologies however reference architecture integrating iot services either two technologies still open research challenge article adopt resource oriented approach provide end end integration architecture front end iot devices back end business process applications proposed architecture promises programmer friendly access iot services event management mechanism propagate context information iot devices service replacement facility upon service failure decentralized execution iot aware business processes elsevier rights reserved
competitive sports number physiological biomechanical environmental psychological factors interact cause increased susceptibility vulnerability injury better understand importance psychological variables origin injuries number previous studies identified certain factors could predict sports injuries aim study analyze influence psychological characteristics associated athletic performance competitive trait anxiety mood injury occurrence participants athletes members specialization programs administered psychological inventory athletic execution iped sport competition anxiety test scat profile mood states poms subsequent lesions recorded period months results indicate self confidence competitive trait anxiety significant predictors number injuries moreover relationship injuries anxiety self confidence maintained effect variables controlled results discussed series considerations applied level proposed
purpose review sphenopalatine ganglion spg block used clinicians treatment variety headache disorders facial pain syndromes facial neuralgias sensory autonomic fibers travel spg provided scientific rationale symptoms associated head neck syndromes yet despite elucidation pathogenic target optimal method block pain producing properties determined clinicians developed various invasive non invasive techniques shown variable rates success examined available studies sphenopalatine ganglion blockade efficacy treatment cluster headaches migraines trigeminal autonomic cephalalgias recent findings studies demonstrated spg blockade neurostimulation provide pain relief patients cluster headaches migraines trigeminal autonomic cephalalgias patients conditions showed varying levels duration pain relief spg blockade efficacy spg blockade could related different techniques targeting spg choice therapeutic agents summary based current studies spg blockade safe effective treatment chronic headaches cluster headaches migraines trigeminal autonomic cephalalgias future studies warranted define optimal image guided technique choice pharmacologic agents spg blockade effective treatment chronic headaches related activation sphenopalatine ganglion
caregivers children living hiv aids clwha face unique challenges due disease related stigma discrimination isolation society financial constraints grief mortality loved one descriptive cross sectional study conducted udupi art centre assess caregiver burden psychological distress associated factors among caregivers clwha udupi district convenience sampling technique used collect data caregivers analysed help spss version majority caregivers female mean age years caregivers hiv positive biological parents clwha mild severe caregiver burden zarit burden inventory zbi reported among caregivers mild severe psychological distress general health questionnaire ghq reported among caregivers relationship child found significant predictor caregiver burden compared relatives foster relationship child alcohol use schooling children reported significant predictors psychological distress study concludes caregiver burden psychological distress high among caregivers clwha psychological problems caregivers need addressed integrated along clinical care hiv infected children art centres
sparse modeling widely successfully used many applications computer vision machine learning pattern recognition accompanied applications significant research studied theoretical limits algorithm design convex relaxations sparse modeling however theoretical analyses non negative versions sparse modeling limited literature either noiseless setting scenario specific statistical noise model gaussian noise paper studies performance non negative sparse modeling general scenario observed signals unknown arbitrary distortion especially focusing non negativity constrained penalized least squares gives exact bound problem recover correct signal elements pose two conditions guarantee correct signal recovery minimum coefficient condition nonlinearity versus subset coherence condition former defines minimum weight correct atoms present signal latter defines tolerable deviation linear model relative positive subset coherence novel type coherence metric provide rigorous performance guarantees based conditions experimentally verify precise predictive power hyperspectral data unmixing application
aimsterms used field chronic pelvic pain cpp poorly defined often confusing international continence society ics standard terminology chronic pelvic pain syndromes cpps developed aim improving diagnosis treatment patients affected chronic pelvic pain syndromes standard aims facilitate research enhance therapy development support healthcare delivery healthcare providers patients document looks whole person domains organ systems systematic way methodsa dedicated working group instituted ics standardisation steering committee according published procedures extracted information existing relevant guidelines consensus documents scientific publications medline databases searched relation chronic pelvic pain domain existing ics standards terminology utilized appropriate ensure transparency accessibility flexibility evolution consensus based majority agreement resultsthe multidisciplinary cpps standard reports updated consensus terminology nine domains lower urinary tract female genital male genital gastrointestinal musculoskeletal neurological aspects psychological aspects sexual aspects comorbidities described terms symptoms signs evaluation conclusionthe document presents preferred terms definitions symptoms signs evaluation diagnostic work female male patients chronic pelvic pain syndromes serving platform ongoing development field neurourol urodynam wiley periodicals inc
paper proposes new method generate interpolation paths two given molecular conformations relies rigid possible arap paradigm used computer graphics manipulate complex meshes preserving essential structural characteristics adaptation arap approaches case molecular systems presented contribution experiments conducted large set benchmarks show strategy efficiently compute relevant interpolation paths large conformational rearrangements
uva irradiation induced skin damage redox imbalance shown ameliorated ergothioneine egt naturally occurring sulfur containing amino acid however responsible molecular mechanism nanomolar concentrations egt remains unclear investigated dermato protective efficacies egt uva irradiation elucidated underlying molecular mechanism human keratinocyte derived hacat cells found egt treatment prior uva exposure significantly increased cell viability prevented lactate dehydrogenase release medium uva induced ros comet like dna formation remarkably suppressed egt parallel inhibition apoptosis evidenced reduced dna fragmentation tunel caspase activation bcl bax dysregulation furthermore egt alleviated uva induced mitochondrial dysfunction dose dependent increases antioxidant genes nqo gamma gclc glutathione egt associated upregulated nrf downregulated keap expressions confirmed increased nuclear accumulation nrf inhibition nrf degradation notably augmented luciferase activity may explain nrf mediated signaling pathways behind egt dermato protective properties demonstrated nrf translocation mediated pik akt pkc ros signaling cascades phenomenon confirmed suppressed nuclear nrf activation consequently diminished antioxidant genes cells treated respective pharmacological inhibitors gfx acetylcysteine besides increased basal ros egt appears crucial triggering nrf signaling pathways silencing nrf octn egt carrier protein signaling sirna showed protective effects egt uva induced cell death ros apoptosis evidence vitality nrf translocation protective efficacy egt keratinocytes findings conclude egt nanomolar concentrations effectively ameliorated uva induced skin damage may considered desirable food supplement skin protection preparation skin care products published elsevier inc
among species expressing parental care males testosterone often low cooperate females raise offspring humans low testosterone men might advantage nurturant partners parents less prone anger reactive aggression empathetic however humans engage cooperative supportive relationships beyond nuclear family prosocial capacities likely critical evolutionary success despite diversity human prosociality prior study tested whether men testosterone also reduced participate emotionally supportive relationships beyond partnering parenting draw testosterone emotional social support data collected older men mean years age enrolled national health nutrition examination survey nationally representative study men reported receiving emotional support two sources lower testosterone men reporting zero support males support sources also lower testosterone one source support men reported emotional support diverse kin non kin multiple kin sources lower testosterone support expanding research partnering parenting findings consistent notion low testosterone downstream facilitates array supportive social relationships results contribute novel insights intersections health social support physiology elsevier inc rights reserved
disasters present unique challenges teams providing medical assistance populations impacted event scoping review focused characteristics medical teams disaster characteristics developed scoping review methods arksey malley followed inductive thematic analysis selected articles used identify recurrent themes total articles reviewed eight databases yielding articles four recurrent theme groups identified adaptability flexibility improvisation creativity innovation experience training leadership command structure study highlighted key characteristics identified responders effective team functioning interdependence characteristics also identified paucity literature subject results study help guide future research training development medical teams disaster
three basic cable equations proposed evaluating deflected shape main cables suspension bridges subject angular changes near saddles main towers well cable bands secondary stress tensioned parallel wires estimated via combined use three basic cable equations take account free friction slip wires function lateral restraints cable bands wrapping wires series laboratory loading tests carried parallel wire strand validate proposed procedure proposed method also applied sun sin bridge demonstrate level secondary stress parallel wires identify factors impact secondary stress completed stage well construction phase residual tension wrapping wire impacts frictional resistance wires main cable measured field tests evaluated secondary stress found exceed tensile strength wires findings reported herein also confirm distance tower saddle first cable band critical factor secondary stress based experimental validation application actual bridge proposed approach despite based simplified formulations demonstrated useful predicting secondary stress develops parallel wire cables
prior research indicated spontaneous trait inferences stis occur easily among fifth graders among adults although stis generally develop among westerners however prior studies sti include asian children study explored development stis among japanese fifth graders seventh graders undergraduates experiments used relearning paradigm participants recollections photo trait pairs presented congruent behaviours compared presented incongruent behaviours participants showed better recollection presented congruent behaviour descriptions saving effects indicated made stis behaviour results showed stis occur among japanese children adults although occurrence associated trait valence factor stis occurred small extent positive trait implying descriptions among fifth seventh graders undergraduates contrast stis occurred clearly negative trait implying descriptions age groups results experiment used trait rating task required less storage capacity long term memory confirmed fifth seventh graders well adults made spontaneous inferences specific traits implied behavioural descriptions wide positivenegative framework developmental model stis depending trait valence culture discussed
consumers choice health plan risk selection often serious problem germany israel netherlands united states america switzerland risk selection may threaten quality care chronically ill people may reduce affordability efficiency healthcare therefore important question regulator show evidence risk selection although seems easy showing evidence straightforward novelty paper two fold first provide conceptual framework showing evidence risk selection competitive health insurance markets easy disentangle risk selection insurers efficiency suggest two methods measure risk selection biased insurers efficiency measures underestimate true risk selection also provide list signals selection measured particular combination show evidence risk selection impossible show absence risk selection second empirically measure risk selection among switchers taking account insurers efficiency based year administrative data healthcare expenses risk characteristics nearly individuals basic health insurance netherlands million find significant risk selection health insurers first publication hard empirical evidence risk selection dutch health insurance market
background symbiotic relationships insects bacteria found across almost insect orders including hymenoptera however still many remaining questions associations including factors drive host associated bacterial composition better understand evolutionary significance association nature studies addressing diversity hosts across locations evolutionary history necessary ants genus polyrhachis spiny ants distributed across old world exhibit generalist diets habits using next generation sequencing ngs bioinformatics tools study explores microbial community species polyrhachis distributed across old world compares microbiota samples related hosts across different biogeographic locations context phylogenetic history results predominant bacteria across samples enterobacteriaceae blochmannia likely many new strains followed wolbachia multiple strains lactobacillus thiotrichaceae acinetobacter nocardia sodalis others recovered exclusive strains enterobacteriaceae specific subgenera polyrhachis corroborating idea coevolution host bacteria bacterial group correlation results partial mantel mantel tests found host phylogeny influence overall bacterial community geographic location effect conclusions work revealing important aspects biology hosts structuring diversity abundance host associated bacterial communities including role host phylogeny shared evolutionary history
innate capacity body person self recovery healing key concept osteopathy basis clinical management broad range conditions believed health functionality improved supporting person self recovery processes particular removing structural biomechanical obstacles may impede body capacity engage effectively recovery clinical approach supporting conceptual framework often referred structural model however research findings last three decades challenged plausibility structural model imply role osteopathy supporting health recovery needs reconsidered response findings alternative management called process approach proposed approach aims directly support processes associated recovery namely repair adaptation alleviation symptoms masterclass article discuss current scientific challenges structural model osteopathy physiological practical therapeutic limitations model supporting recovery processes present reasoning principles process approach osteopathic care published elsevier ltd
feature size integrated devices entered nanometer single electron transistor set satisfied nanoelectronic devices set mixed composition nano mos devices setmos one hot current study setmos new hybrid device combine advantages also coulomb oscillation characteristics set mos high gain integrated analog signal processing filters basic unit circuit must conform development times paper based setmos hybrid device characteristics model setmos integrator realized based model second order low pass filter designed implemented using setmos integrator expounded structure operating condition performance parameter characteristics setmos second order low pass filter analyzed transmission characteristics gain filter well cutoff frequency parameters related theory explained hybrid setmos second low pass filter nano circuit worked frequency band transmission performance filter designed simulated spice simulation results confirm hybrid setmos filter good frequency characteristics pass band range low voltage low power high frequency characteristics demonstrated setmos second low pass filter method proposed paper also applicable analog circuits composed hybrid setmos architectures
discovery expansion hexanucleotide repeat within noncoding region corf gene causes amyotrophic lateral sclerosis frontotemporal dementia raised questions corf protein function potential disease relevance major predicted structural feature corf protein denn differentially expressed normal neoplastic cells domain denn domains best characterized regulation specific rab gtpases proposed corf may also act regulation gtpase target recent genetic cell biological studies furthermore indicate corf protein functions lysosomes part larger complex also contains smith magenis chromosome region smcr repeat containing protein wdr proteins important role corf lysosomes supported defects lysosome morphology mtor complex mtorc signaling arising corf diverse model systems collectively new findings define corf containing protein complex lysosomal site action central corf function provide foundation elucidation direct physiological targets corf elucidation mechanisms whereby corf regulates lysosome function help determine reductions corf expression levels accompany hexanucleotide repeat expansions contribute disease pathology
greater strength thermal conductivity component parts portable electronic devices increasingly required due increased degree integration shock factor result mobility regard necessary conduct research improve physical properties using crystallized glass alumina filters study focused identification regions anorthite glass anorthite crystals diopside crystals alumina phase coexist observed alo react anorthite system glass create anorthite crystals course sintering also reacted diopside phase generated mgalo however average particle diameter alo relatively large mgalo created following addition alo less result evaluation strength thermal conductivity found physical properties rapidly fell phase mgalo generated
water essential human survival although approximately world covered water fresh water hence fresh water valuable resource must carefully monitored maintained developing countries people without access potable water cholera still reported countries africa drinking water comes underground sources makes water monitoring issue key concern water monitoring used track water quality changes time identify existing emerging problems design effective intervention programs remedy water pollution important detailed knowledge potable water quality enable proper treatment also prevent contamination article review methods water quality monitoring wqm traditional manual methods technologically advanced methods employing wireless sensor networks wsns situ wqm particular highlight recent developments sensor devices data acquisition procedures communication network architectures power management schemes maintain long lived operational wqm system finally discuss open issues need addressed advance automatic wqm using wsns
limited research examined social context surrounding stigma discrimination hiv outcomes among people living hiv plhiv surveyed plhiv brazil examined relationship stigma discrimination hiv outcomes utilising multivariable logistic regression hiv stigma discrimination inversely associated age aor stigma aor discrimination income aor stigma aor discrimination stigma inversely associated education aor history sex work aor positively associated children aor discrimination inversely associated history drug use aor stigma discrimination found inversely associated overall health aor stigma aor discrimination discrimination associated sexually transmitted infection since hiv diagnosis aor findings suggest future interventions address multiple social inequalities faced plhiv reduce hiv stigma discrimination improve health hiv outcomes
coding considered educators fundamental skill everybody awareness campaigns launched worldwide last two years attracted attention media initiated tens millions people ages computer programming availability online visual programming platforms like scratch blockly freely accessible playful educational tools like ones offered code org significantly contributed lower access barrier coding making possible acquire computational thinking skills playing need master syntax programming language widespread diffusion internet connected objects embedded processors added power coding making essential skill allows exploit unprecedented potential smart objects around nowadays online visual programming platforms mobile applications make possible use block based programming develop full fledged mobile applications thus combining immediacy visual programming attractiveness mobile applications pan european crowdcoding educational experiment launched october europe code week involve people programming skills development new mobile game android called flagship officially released european commission promote computing literacy specifications disclosed beginning code week fist full fledged version released last day result international coding relay race involving people many countries university urbino took care merging contributions conducting live coding sessions corresponding milestones roadmap appinventor adopted development platform order make coding steps accessible neophytes programming phases streamed live recorded video logs incremental appinventor project files made available online used tutorials paper reports details crowdcoding experiment discusses motivations results outlines current status future directions flagship project
automatic segmentation subtitles novel research field studied extensively date however quality automatic subtitling real need broadcasters seek automatic solutions given demanding european audiovisual legislation article method based conditional random field presented deal automatic subtitling segmentation continuation previous work field proposed method based support vector machine classifier generate possible candidates breaks study two corpora basque spanish used experiments performance current method tested compared previous solution two rule based systems several evaluation metrics finally experiment human evaluators carried aim measuring productivity gain post editing automatic subtitles generated new method presented elsevier rights reserved
large amount variables need taken account studying effects violent content digital games one difficulty current study participants played modified first person shooter one four different conditions either high low difficulty high low violent game content assessed number kills number deaths game performance neither difficulty displayed violence effect psychophysiological arousal play post game aggressive cognitions aggressive behavior thus study corroborates previous research indicating violence games substantially influence human behavior experience game characteristics deserve attention game effects studies addition findings showed challenge manipulated game difficulty main importance post game emotions number deaths predicted positive affect low difficulty condition number kills positive predictor positive affect negative predictor negative affect elsevier ltd rights reserved
paper novel current mode square triangular wave oscillator based second generation current conveyor ccii operating resistance capacitance time conversion described proposed oscillator consists two ccii active element three grounded resistances one capacitance found effective alternate voltage mode based interfaces wide range capacitive resistive sensors interface circuit implemented commercially available current feedback operational amplifier analog devices passive components experimental results confirmed theoretical expectations showing good linearity wide oscillation frequency period range independently adjusted resistive capacitive external passive components experimental measurement also conducted fabricated capacitive humidity sensor verify real time application proposed interface circuit interface circuit shown good accuracy linearity wide variation capacitance humidity sensor
pragmatic competence may disrupted due psychological neurological causes appropriate remedy rehabilitation precise assessment pragmatic skills important however test battery bengali language consequently published data pragmatic ability bengali speakers due vast diversity population becomes increasingly difficult assess pragmatic ability individual without proper knowledge normal variations address problem developed test battery bengali begin administered one hundred five normal healthy persons different levels education four groups years years years years education yielded normative score respectively normative scores allow clinicians make proper assessment patients suffering pragmatic deficits help avoid interpreting social differences neurological deficits
increasing use databases abundant opportunity investigate new watermarking techniques cater requirements emerging applications major challenge needs tackled recover crucial information may lost accidentally due malicious attacks database represents asset needs protection paper elucidate scheme robust watermarking multiple watermarks resolve twin issues ownership recovery information case data loss resolve ownership conflicts watermark prepared securely embedded secretly selected positions database watermark encapsulates granular information user specified crucial attributes manner perturbed lost data regenerated conveniently later theoretical analysis proves probability identifying target locations false hit rate false miss rate negligible experimentally verified proposed technique robust enough extract watermark accurately even tuple addition alteration tuple deletion experiments information recovery reveal successful regeneration tampered lost data improves increase number candidate attributes embedding watermark elsevier ltd rights reserved
background objectives early phase virtual screening candidate drug molecules plays key role pharmaceutical industry data mining machine learning prevent adverse effects drugs computational classification methods distinguish approved drugs withdrawn ones focused data sets including maximum approved withdrawn drugs nervous system diseases distinguish approved drugs withdrawn ones methods study used support vector machines svms ensemble methods ems boosted bagged trees classify drugs approved withdrawn categories also used corina symphony program identify toxprint chemotypes including predefined chemotypes determination risk safety assesment candidate drug molecules addition studied nervous system withdrawn drugs determine key fragments parmol package including gspan algorithm results according results descriptors named number total chemotypes bond amine aliphatic generic significant descriptors developed medium gaussian svm model reached prediction accuracy test set drug data set including disease bagged tree linear svm models showed accuracies phycholeptics psychoanaleptics drugs set discriminative fragments nervous system withdrawn drug nswd data sets obtained fragments responsible drugs removed market benzene toluene dimethylethylamine crotylamine methyl heptadiene octatriene carbonyl group conclusion paper covers development computational classification methods distinguish approved drugs withdrawn ones addition results study indicated identification discriminative fragments significance design new nervous system approved drugs interpretation structures nswds elsevier rights reserved
online visual analytical system based java web webgis air quality data shanghai municipality designed implemented quantitatively analyze qualitatively visualize air quality data analyzing architecture webgis java web firstly designed overall scheme system architecture put forward software hardware environment also determined main function modules system visual system ultimately established div css layout method combined jsp javascript computer programming languages based java programming environment moreover struts spring hibernate frameworks ssh integrated system purpose easy maintenance expansion provide mapping service spatial analysis functions selected arcgis server gis server also used oracle database esri file geodatabase store spatial data non spatial data order ensure data security addition response data web server resampled implement rapid visualization browser experimental successes indicate system quickly respond user requests efficiently return accurate processing results
paper presents laboratory set used wind turbine emulator emulator used research applications drive electrical generator similar way wind turbine reproducing torque developed wind turbine given wind velocity also used educational tool teach behaviour operation control wind turbine work turbine torque reproduced drive control program reads wind velocities input file calculates torque reference drive commercial drive torque control used apply commanded torque shaft electrical generator stall wind turbines pitch controlled wind turbines emulated laboratory set emulator reproduced mean torque turbine also oscillating torque due wind shear tower shadow functionality emulator used investigate effect phenomena power quality experimental results given show emulator useful tool purposes already mentioned
since emergence sophisticated interaction devices human computer interaction hci science extended forms non verbal communication nvc one added issues context use gestures actions expressed body face hands natural solution applications require hands free touch interaction computers suggested virtual reality environments paper introduces interaction system based gestures implies real time hand gesture recognition tracking method identify different dynamic hand postures control tools virtual world order improve user experience set different system functions virtual world implemented interaction performed user execution gestures data glove device ability perform implemented gestures participants group used critical evaluation system obtained results show high percentage evaluated participants found system user friendly
current sensing widely used power electronic applications power converters adjustable speed motor drives power converters basic building blocks drivetrains electric hybrid plug hybrid electric vehicles performance control vehicles depend accuracy bandwidth efficiency sensors various current sensing techniques based different physical effects faraday induction law ohm law lorentz force law magnetoresistance effect magnetic saturation effect described paper technique reviewed examined current measurement methods compared analyzed based losslessness simplicity ease implementation
possibility measure instant current consumption electrical devices branches electrical network without specialized sensors evaluated shown types electrical networks neutral conductor could used current sensing device reading voltage difference neutral conductor protective conductor supply helpful information load
sensory evaluation garment silhouettes comprehensive important index evaluating sense clothes paper behavior experiment used collect data instead questionnaire traditional research garment sensory perception results show main effect silhouette element interaction effects elements sensory perception quite different information integration garment silhouette sensory perception differed different emotional integration model mathematical model constructed paper provide basis integrating perception information color hand feeling sensory evaluation garment method paper provide creative idea studying garment featured pattern research computer vision
background aims nutritional therapy viable therapeutic option treatment crohn disease therefore improving nutritional therapy would greatly benefit patients aim study define anti inflammatory properties novel nutritional polymeric formula comparison currently available standard methods dextran sodium sulfate dss utilized induce colitis cbl mice mice randomized receive either standard novel addition control groups changes body weight recorded colonic damage assessed histologically biochemically additional experiments also included cytokine response colonic biopsies pediatric patients measured following exposure standard novel results dss induced significant body weight loss morphological changes colon increased myeloperoxidase mpo activity regulated colonic mrna expression tumor necrosis factor tnf alpha interleukin monocyte chemoattractant protein mcp well associated histological changes histological damage inflammatory changes reversed novel standard however novel standard completely suppressed tnf alpha levels cultured biopsies conclusions newly developed nutritional formula reproducibly ameliorated dss induced colitis murine model although response measurably different standard however novel significantly superior suppressing inflammatory cytokine release cultured colonic biopsies collectively findings support possible role novel advancing nutritional therapy patients crown copyright published elsevier ltd rights reserved
objective study assessed positive changes patients advanced colorectal cancer family caregivers following diagnosis compared self reported positive changes within patient caregiver dyads well self reports patient reports positive changes caregivers design individual semi structured qualitative interviews conducted patients advanced colorectal cancer caregivers theoretical thematic analysis interview transcripts framed posttraumatic growth theory results patients caregivers described five positive changes closer relationships others greater appreciation life clarifying life priorities increased faith empathy others additionally caregivers reported better health habits following cancer diagnosis minority patients caregivers reported positive changes half cases patients reported least one positive change identical caregiver however cases patient caregiver reports caregiver positive change discrepant conclusion findings suggest positive changes shared experience many patient caregiver dyads obtaining patient caregiver reports caregiver positive changes provides comprehensive understanding experience interventions may capitalise positive changes promote meaningful living context advanced cancer
article examines effectiveness different forms performance based adaptive automation pbaa using data three experiments different models algorithm design compared effectiveness driving pbaa following components varied type task primary secondary tasks baseline performance data moving average triggering criterion level deviation standard performance data generated operators working computer based simulation process control environment results showed none models enjoyed convincing level effectiveness automation algorithms generally achieved higher levels miss prevention false alarm prevention surprisingly primary task performance generally better driving pbaa secondary task performance results suggest may difficult design effective algorithm pbaa work environment highly complex
purposeto describe prevalence clinical correlates insomnia schizophrenia patients treated primary care design methodssix hundred twenty three schizophrenia patients primary care services recruited findingsthe prevalence least one type insomnia difficulty initiating sleep difficulty maintaining sleep early morning wakening respectively patients suffering insomnia received treatment practice implicationsinsomnia common chinese patients schizophrenia treated primary care rate treatment appears low
paper presents approach tracing parasitic noise propagation paths printed circuit boards approach allows identification dominant paths transporting significant noise power peripheral connector pin sensitive device pin identification paths performed frequency domain using scattering parameters graph searching algorithms approach combined harmonic balance technique time domain analysis nonlinear components superposition limited number extracted dominant noise propagation paths frequency time domain gives good approximation total system response method used improve interconnect design physical implementation circuitry
multiracial individuals often easily fit existing racial categories perceivers may adopt novel racial category categorize multiracial targets willingness may depend motivations investigated whether perceivers levels internal motivation control prejudice ims external motivation control prejudice ems predicted likelihood categorizing black white multiracial faces multiracial across four studies ims positively predicted perceivers categorizations multiracial faces multiracial association ims multiracial categorizations strongest faces racially ambiguous explicit prejudice implicit prejudice interracial contact ruled explanations relationship ims multiracial categorizations ems may negatively associated use multiracial category therefore perceivers motivations control prejudice important implications racial categorization processes
visual tracking fundamental research topic computer vision community great importance many application areas including augmented reality traffic control medical imaging video editing paper presents ordered relaxation langevin monte carlo sampling orlmc based tracking method within bayesian filtering framework traditional object state variable augmented auxiliary momentum variable proposal step proposal distribution designed simulation hamiltonian dynamics first use ordered relaxation method draw momentum variable could suppress random walk behavior gibbs sampling stage leverage gradient energy function posterior distribution draw new samples high acceptance ratio proposed tracking method could ensure tracker trapped local optimum state space experimental results show proposed tracking method successfully tracks objects different video sequences outperforms several conventional methods elsevier rights reserved
food intake measurements essential many research studies provide detailed description novel solution measuring food intake mice feeding experimentation device fed fed open source system designed facilitate flexibility food intake studies due compact battery powered design fed placed within standard home cages experimental equipment food intake measurements also synchronized equipment real time via fed transistor transistor logic ttl digital output post acquisition processing fed timestamps every event real time clock use food pellet sits within fed food well monitored via infrared beam pellet removed mouse fed logs timestamp onto internal secure digital card dispenses another pellet fed run days necessary charge battery refill pellet hopper minimizing human interference data collection assembly fed requires minimal engineering background shelf materials electronics prioritized construction also provide scripts analysis food intake meal patterns finally fed open source design construction files online facilitate modifications improvements researchers
lameness major issue dairy herds early automated detection offers animal welfare benefits together potentially high commercial savings farmers current advancements automated detection achieved sensitive measure classifying early lameness novel proxy lameness using dimensional depth video data analyse animal gait asymmetry introduced dynamic proxy derived height variations hip joint walking video capture setup completely covert facilitates automated process animals recorded using overhead depth camera walk freely single file milking session depth image cow body used automatically track key regions hooks spine height movements calculated regions form locomotion signals study analysed using hilbert transform results using locomotion scoring system holstein friesian dairy cows threshold could identified boundary important represents earliest point time cow considered lame early detection could improve intervention outcome thereby minimising losses reducing animal suffering using linear support vector machine svm binary classification model threshold achieved accuracy sensitivity detecting lame cows specificity detecting non lame cows iagre published elsevier ltd rights reserved
imbalance regulatory cells tregs helper cells contributes persistent hepatitis virus hcv infection however modulatory factors associated tregs balance fully elucidated arecent study demonstrated immunoregulatory strategy inactivation notch signaling reverse disequilibrium tregs cells immune thrombocytopenia thus aim study assess effect notch signaling regulating functions tregs cells chronic hepatitis total patients chronic hepatitis normal controls ncs enrolled mrna expressions notch notch semiquantified real time reserve polymerase chain reaction percentages tregs levels key transcriptional factors cytokine productions measured response treatment dapt gamma secretase inhibitor suppress notch signaling found notch notch mrnas significantly elevated peripheral blood mononuclear cells chronic hepatitis patients compared ncs dapt treatment reduced response downregulation ror gamma expression interleukin secretion tregs proportion foxp expression production change significantly dapt treatment chronic hepatitis however blockage notch signaling inhibited suppressive function tregs moreover effective anti hcv therapy reduced notch notch expression also decreased tregs proportions current data provided novel mechanism underlying modulation treg balance link notch signaling cells might lead new intervention breaking immunotolerance chronic hcv infection
communication global software development hindered language differences countries lack english speaking professionals machine translation technology uses software translate one natural language another progress machine translation systems steady last decade machine translation technology particularly appealing might used form cross language chat services countries entering global software projects however despite recent progress technology still lack thorough understanding real time machine translation affects communication paper present set empirical studies goal assessing extent real time machine translation used distributed multilingual requirements meetings instead english results suggest despite far accurate real time machine translation disruptive conversation flow therefore accepted favor participants however stronger effects expected emerge language barriers critical findings add evidence recent advances machine translation technology provide guidance global software engineering practitioners regarding losses gains using english lingua franca multilingual group communication case computer mediated requirements meetings
paper based temperature dependent fracture surface energy model traditional griffith fracture theories new temperature dependent fracture strength model zrb sic composites developed combined effects temperature grain size microflaw size residual stress strength zrb sic composites included new model according model temperature dependent fracture strength materials easily predicted using basic material parameters model verified different temperatures comparison experimental data different zrb sic composites excellent agreement obtained predicted experimental data fracture strength zrb sic composites elsevier ltd rights reserved
use nonwoven geotextile drains geosynthetic reinforced soil grs structures suggested facilitate dissipation pore water pressure also recognised nonwoven geotextile may retard water penetration due capillary barrier effect unsaturated soil conditions function drainage material soil immediately nearly saturated study numerical models unsaturated slopes nonwoven geotextile drains subjected rainfall infiltration developed investigate unsaturated hydraulic behaviour stability slopes constructed nonwoven geotextile drains thin layers highly permeable sand sand cushions numerical models first validated suitability modelling water flow capillary barrier effect within unsaturated soils using experimental results one dimensional soil column infiltration test full scale infiltration tests next series numerical simulations unsaturated slopes without sand cushions different infiltration conditions performed numerical results indicated sand cushions reduced development capillary barrier effect acting intermediate material backfill nonwoven geotextile bridged gap two materials different unsaturated hydraulic characteristics reduction development capillary barrier effect led accumulation pore water pressure nonwoven geotextile effectively dissipated downward sand cushions also acted additional drain layers facilitate drainage water within slope system thus inclusion sand cushions enhanced local slope stability soils top geotextile layer based numerical results methods determining occurrence capillary barrier effect identified literature discussed
main objective paper propose alternative stormwater management low income communities settled urban vertical slums located areas insufficient infrastructure degraded environment case study located rio janeiro city brazil presented high slopes studied area used favor superficial flows generating alternatives traditional stormdrains used collect runoff upstream reaches small reservoir proposed house reducing flood volumes allowing rainwater harvesting greater retention reservoir introduced storage measure connecting microdrainage coming informal city formal city different scenarios simulated aid mathematical model called modcel results showed possible apply effective drainage system solution informal areas without affecting already implemented downstream formal drainage network retention reservoir proposed also introduces possibility act improving water quality downstream areas although complementary aspect developed study
present code generating synthetic spectral energy distributions intensity maps smoothed particle hydrodynamics simulation snapshots code based lucy monte carlo radiative transfer method follows discrete luminosity packets propagate density field uses trajectories compute radiative equilibrium temperature ambient dust sources extended embedded discrete diffuse density mapped grid therefore calculation performed exactly resolution hydrodynamics present two example calculations using method first demonstrate code strictly adheres kirchhoff law radiation secondly present synthetic intensity maps spectra embedded protostellar multiple system algorithm uses data structures already constructed purposes modern particle codes therefore relatively simple implement
appearance graphic computing allowed deal analysis two three dimensional structural continuum means mechanic models capacity understand simplest complex behaviors local geometries classic methodologies able describe fact involves adoption elasticity theory prominence stresses comfortable view simplify along one geometry dimensions one beam edges convert strains strength materials concepts vectorial calculus might become outdated nowadays moreover finite element method used study allows facing structural geometries geometric functional complexity would possible classic methods without introducing important simplifications
slotted axial flux machines excellent power torque densities however difficult reduce cogging torque due complexity associated implementing classical techniques paper slot opening widths tooth profiles shown significant mitigating cogging torque machines particular varying slot opening reduced whereas parallel tooth rectangular profile lowered compared conventional trapezoidal tooth profile analytical quasi analysis formulated used analyze determine cogging torque validated numerically experimentally versatility ability analyze different shapes poles slot openings extended model air gap nonuniformity paper also presents cogging torque minimization techniques maintain ease manufacture parallel tooth stator experimental results showed reduction cogging torque achieved use alternating pole arcs skewed poles
objective study investigate whether acute pain abused children recognized doctors nurses compared children evaluated accidental injuries hypothesize abused child reaction physical pain could additional symptom challenging diagnosis observational prospective case control study emergency department children eligible younger six years old reported trauma occurred within previous seven days trauma comprised bone injury burn child able express pain case group comprised children medical team reported abuse suspicions supporting information court whose cases abuse subsequently confirmed control group consisted children plausible cause injury obvious signs abuse children matched according age type trauma pain assessed doctors nurses analgesic administration using certified pain scale among included children pain significantly less recognized abused children controls relative risk observed discrepancy nurses doctors scores pain assessments kappa coefficient results demonstrate pain expression abused children recognized medical staff also suggest abused children may reduced pain expression traumatic event paying particular attention pain abused children may also optimize analgesic treatment elsevier ltd rights reserved
united states made substantial progress reducing teenage birth rates recent decades rates remain high teen pregnancy increase risk poor health outcomes lead decreased educational attainment increased poverty welfare use well increased cost taxpayers one effective ways prevent teenage pregnancy use effective birth control methods centers disease control cdc prevention made prevention teenage pregnancy winnable battles cdc released evidence based clinical guideline documents regarding contraceptive use adolescents adults first guideline medical eligibility criteria contraceptive use helps clinicians recognize contraceptive method may safe use particular adolescent also withhold contraceptive method safe use second document selected practice recommendations contraceptive use provides guidance use contraceptive methods safely effectively deemed safe health care providers encouraged use documents provide safe effective contraceptive care patients seeking family planning including adolescents
paper system coupled interacting models dynamic electric thermal behavior electrical machine presented models specifically designed maximum execution speed suitable simulating machine behavior long time periods even entire lifetime machine nevertheless results proved remarkably accurate arbitrary electrical faults thermal asymmetries simulated influence winding resistance magnet temperature machine behavior implemented machine models connected lifetime models winding insulation different locations bearings aging machine components driving cycle cadc investigated healthy case given machine design temperature distribution inside machine analyzed specific driving cycle
paper show successful integration measurement code quality software development process besides choosing suitable tool code analysis metrics proper threshold values concepts removal deficiencies important requirements code quality several cycles development process necessary achieve long term effective integration code quality development process integration static analysis refactoring program code achieved plan check act cycle didactic methods software development course university
background metabolic syndrome might increase risk cardiovascular disease testicular cancer survivors investigated prevalence development vascular implications role gonadal function methods survivors treated chemotherapy follow years study retrospectively evaluated development cardiovascular risk factors subgroup followed years study compared controls prevalence evaluated vascular function results survivors study developed overweight hypercholesterolemia hypertension median follow years respectively median follow years study survivors odds ratio confidence interval compared controls survivors features inflammation prothrombotic state increased carotid artery intima media thickness survivors testosterone levels nmol increased risk conclusions current data suggest occurs earlier age survivors treated chemotherapy compared controls accompanied early signs atherosclerosis low testosterone may causal role target interventions
background aims sex sex hormones affect responses patients nonalcoholic fatty liver disease nafld metabolic stress development hepatocyte injury inflammation methods collected data large studies patients nafld october june assess association histologic severity sex menopause status synthetic hormone use menstrual abnormalities patients histologic diagnosis nafld performed logistic ordinal logistic regression models adjusting covariates relevant increase hepatic metabolic stress results premenopausal women increased risk lobular inflammation hepatocyte ballooning mallory denk bodies men also increased risk lobular inflammation mallory denk bodies postmenopausal women use oral contraceptives associated increased risk lobular inflammation mallory denk bodies premenopausal women whereas hormone replacement therapy associated increased risk lobular inflammation postmenopausal women conclusions premenopausal woman female user synthetic hormones associated increased histologic severity hepatocyte injury inflammation among patients nafld given levels hepatic metabolic stress
wireless body area network wban key element health monitor bodies technology enables new applications umbrella different domains including medical field entertainment ambient intelligence areas survey paper places substantial emphasis concept key features wban technology first wban concept introduced review key applications facilitated networking technology provided study explores wide variety communication standards methods deployed technology due sensitivity criticality data carried handled wban fault tolerance critical issue widely discussed paper hence survey investigates thoroughly reliability fault tolerance paradigms suggested wbans open research challenging issues pertaining fault tolerance coexistence interference management power consumption also discussed along suggested trends aspects
paper presents proposed new approach complex control combining several simpler individual fuzzy controllers method particularly useful case study multivariable control system proposed method hierarchical architecture levels individual fuzzy systems superior control adjust global result behavior proposed method illustrated problem flight control requires several individual controllers addition statistical comparison performed using student test proposed control strategy compared simple fuzzy control approach finally optimization method also applied achieve optimal design fuzzy systems elsevier inc rights reserved
today western society concerns regarding body size negative feelings toward one body common however little known neural mechanisms underlying negative feelings toward body relate body perception eating disorder pathology used multisensory illusions elicit illusory ownership obese slim bodies functional magnetic resonance imaging results implicate anterior insula anterior cingulate cortex development negative feelings toward body functional interactions posterior parietal cortex mediates perceived obesity moreover cingulate neural responses modulated nonclinical eating disorder psychopathology attenuated females results reveal perceptual affective body representations interact human brain may help explain neurobiological underpinnings eating disorder vulnerability women
sleep problems circadian rhythms disturbances common many psychiatric disorders mostoften reported sleep problem cases insomnia paper main findings sleep disturbances features therapy biorhythm disturbances biological timekeepers clock genes gsk melatonin hypothalamo pituitary adrenal axis body temperature reviewed relation schizophrenia mood anxiety disorders
elms sawteeth located different parts plasma similar control engineering point view manifest quiescent periods interrupted periodic collapses large collapses following long quiescent periods detrimental effects short periods associated decreased confinement following installation metal iter like wall jet sawteeth elms also play important role expelling tungsten core edge plasma respectively control tungsten therefore added divertor heat load reduction ntm avoidance helium ash removal reasons requiring elm sawtooth control therefore interest implement control systems maintain sawtooth elm frequencies desired ranges jet elm frequency control uses radial field kicks pellet gas injection actuators sawtooth control uses ion cyclotron resonance heating icrh jet experiments first time established feedback control elm frequency via real time variation injected gas flow using controller conjunction pellet injection allows elm frequency kept required despite variations pellet elm triggering efficiency jet sawtooth control experiments first time demonstrated low field side icrh foreseen iter shorten sawteeth lengthened central fast ions development elm sawtooth control could key achieve stable high performance jet discharges minimal tungsten content integrating schemes overall control strategy required future tokamaks gaining experience current tokamaks essential
study evaluated effectiveness clustered forward chaining cfc procedure teach year old male autism follow written recipes cfc incorporates elements forward chaining total task chaining ttc teaching small number steps units using ttc introducing new units sequentially akin prompting untrained steps results indicated cfc effective teaching participant follow written recipes results maintained therapist support weeks recipes maintained therapist support removed
objectives overarching aim article assess media portrayals mental illness canada hypothesise portrayals improved time related various antistigma activities organisations mental health commission canada mhcc specific objectives assess overall tone content newspaper articles change time variables associated positive negative content methods collected newspaper articles print online editions best selling canadian newspapers mentioned key search terms mental illness schizophrenia read research assistants assessed tone content article using preassigned codes categories data subjected chi squared trend analysis results study period articles positive tone stigmatising content trend analysis suggested significantly improved coverage years example articles positive tone almost doubled articles stigmatising content reduced third analysis also suggested articles front page well articles broadsheet newspapers significantly positive coverage conclusions study indicates news media coverage related mental illness improved past decade may related concerted efforts mhcc executed targeted strategy aimed reducing stigma improving media coverage since
investigate aerodynamic effect wind barriers high speed train bridge system sectional model test conducted closed circuit type wind tunnel several different cases including without barriers different barrier heights porosity rates different train arrangements bridge taken consideration addition aerodynamic coefficients train bridge system measured found side force rolling moment coefficients vehicle efficiently reduced single side wind barrier bridge deck values increased height porosity rate barrier two important factors influence windbreak effect train arrangement bridge considerably influence aerodynamic properties train bridge system side force rolling moment coefficients vehicle windward side larger leeward side
eosinophilic copd appears distinct patient subgroup increased corticosteroid response eosinophilic copd labelled part asthma copd overlap syndrome acos compared clinical characteristics eosinophilic copd patients without clinical history asthma copd patients childhood history asthma copd patients asthma characterised allergies exacerbations less eosinophilic inflammation terms acos used lump patients together report distinct differences eosinophilic copd copd patients asthma propose groups split rather lumped
physical training essential every athlete related movement explosive force movement speed also related power training high physical training intensity bound lead occurrence various sports injuries affect progress training even physical mental health athletes based article start problems physical training athletes base put forward feasible countermeasures order provide readers reference
main issues related water conservation urban centers increase water supply cost demand growth pollution differences distribution water resources water conservation controlled efficient use water includes measures reasonable means water reuse thus conservation practices effective way meet demand supply water new activities users without jeopardizing supplying water bodies preserving natural environment study aims examine water management shopping mall use rainwater harvesting combined greywater reuse investigate feasibility water reuse systems buildings general water loss common due leaks hydraulic restroom equipment losses caused high volume water used wasted system often result design errors incorrect maintenance procedures users bad habits southern brazil abundance rainwater water shortages occasionally occur particularly winter one difficulty appears rainwater studies proper determination rainwater volume used address water supply systems work simulation method used determine volume thus simulations following variables rainfall catchment area water consumption performed mall hydraulic systems segmented alternatives adopted focusing use rainwater greywater reuse alternatives underutilized due sanitary issues water toilets kitchen sinks adoption greywater may feasible significant flow greywater comply water demand toilet flushing inspections made study found quantity sinks insufficient supply adequate amount water toilets urinals greywater reuse system found infeasible conversely rainwater harvesting system entirely feasible easily supplied water restrooms contributed cooling air conditioning system short payback period one challenges work need compare actual water consumption water consumption parameter used buildings thus method addresses generation specific consumption indexes specific activity like mall used water consumption indices showed mall satisfactory water management program elsevier ltd rights reserved
social dynamics crowds emergency escape scenarios conventionally modelled net effect virtual forces exerted crowd individual self driven particles magnitude influence formulated decreasing functions inter individual distances direction effect assumed transitioning repulsion attraction distance revisit conventional assumption using laboratory experimental data show based robust econometric hypothesis testing methods individuals perception escapees differs based whether individuals jamming around exit destinations move towards destinations also moving crowds differs based whether escape destination chosen moving flow visible invisible individual presence crowd jams around destination also movement crowd flows towards visible destinations perceived average repulsion disutility effects former showing significantly larger magnitude latter movement crowd flows towards invisible destination however average perceived attraction utility effect yet hypothesis testing showed neither effects isolation determines adequately whether individual would merge diverge crowd rather social interaction factors act significant levels conjunction physical factors environments including spatial distances exit destinations destinations visibility brief finding disentangles conditions individuals likely show mass behaviour situations likely break herd identifies two factors moderate perception social interactions crowds jam movement status environmental setup results particularly challenge taxonomy attraction repulsion social interaction forces defined purely based distance individual surrounding crowd showing crowds could far distance yet perceived repulsion effect could close distance yet act attraction effect elsevier rights reserved
present study maps possible sources unreliability child testimony lower ability remember recall events high suggestibility easier formation false memories misunderstanding processes interactions surroundings probability deliberate lying well potential benefits research counselling practices procedures help improve conversely depreciate information given child child ability understand motivation experience behaviour well behaviour feelings others often questioned despite mentioned risks child testimony useful judicial proceedings child may witness events also psychological research counselling turns child sensitive aspects family life conflicts adult gives even accurate information parents child view family life important understanding behaviour experience
caelyx formulation doxorubicin encapsulated pegylierte liposomes result high liposome stability elimination rate plasma significantly decreased compared free doxorubicin following single dose caelyx given min infusion patients advanced breast cancer area curve auc plasma doxorubicin times higher infusion non encapsulated doxorubicin dose distribution volume caelyx similar human blood volume plasma clearance approximately long term studies detected measurable doxorubicin plasma levels even weeks following administration caelyx appears liposomes extravasate relatively freely fenestrated endothelium tumor vasculature keeping concept tissue concentrations doxorubicin found tumors patients treated caelyx twice surrounding healthy tissues stability pegylated liposomes affected combined administration taxane docetaxel hypersensitivity reactions due caelyx largely avoided prolonging infusion duration min caelyx given intervals weeks cutaneous toxicity foot hand syndrome also remain manageable
paper present novel parallel high order sliding deforming spectral difference method solving two dimensional compressible navier stokes equations unstructured quadrilateral grids method arbitrary lagrangian eulerian ale approach combined novel sliding interface approach separately handle rotational translational motions dynamic grid method shown capable completely removing grid skewness caused rotating boundaries improve solution qualities method verified high order accurate scalable parallel computing distributed memory computer method also proven robust accurate deforming ale approach problems involving large amplitude rotating motions elsevier ltd rights reserved
fast accurate estimation rice yield plays role forecasting rice productivity ensuring regional national food security microwave synthetic aperture radar sar data proved great potential rice monitoring parameters retrieval study rice canopy scattering model rcsm revised applied simulate backscatter rice cahopy combination rcsm genetic algorithm proposed retrieving two important rice parameters relating grain yield ear length ear number density band dual polarization radarsat sar data stability retrieved results inversion also evaluated changing various parameter configurations results show rcsm effectively simulate backscattering coefficients rice canopy mode error reasonable selection parameters essential stability efficiency rice parameter retrieval two rice parameters retrieved proposed rcsm technology better accuracy rice ear length estimated error ear number density error rice grain yields effectively estimated mapped retrieved ear length number density via simple yield regression equation study illustrates capability band radarsat sar data retrieval rice ear parameters practicability radar remote sensing technology operational yield estimation elsevier rights reserved
face recognition applications widely used different fields like security computer vision recognition process done real time take fast decisions principle component analysis pca considered feature extraction technique widely used facial recognition applications projecting images new face space pca reduce dimensionality image however pca consumes lot processing time due high intensive computation nature hence paper proposes two different parallel architectures accelerate training testing phases pca algorithm exploiting benefits distributed memory architecture experimental results show proposed architectures achieve linear speed system scalability different data sizes facial recognition technology feret database
background trigeminal neuralgia described association various primary headache disorders far case reported association hemicrania continua case report report two patients hemicrania continua associated tic syndrome patients headaches concurrently patients responded combination carbamazepine indomethacin skipping tapering carbamazepine led recurrence neuralgic pain way skipping indomethacin resulted relapse pain typical conclusion two cases tic syndrome suggest special predilection types tacs various speculations suggest associations simple coincidence diseases may causally interrelated identification association important disorders may need separate drugs
secondary osteoporosis frequent complication rheumatoid arthritis result imbalance catabolic anabolic mechanisms bone metabolism effects serial low dose radon hyperthermia ldrnht exposure therapeutic adit applications weeks serum levels cytokines osteoprotegerin opg receptor activator kappa ligand rankl tumor necrosis factor alpha tnf alpha also rankl opg ratio investigated patients age matched control patients osteoarthritis cytokine measurements performed baseline completion ldrnht anti ccp antibodies acpa measured patients parallel medication groups limited non steroidal anti inflammatory drugs low dose prednisolone patients needed patients showed significant decrease tnf alpha levels groups showed significantly decreased levels rankl patients presented significant increase opg decrease rankl opg ratio acpa levels ldrnht results reduction osteocatabolic increase osteoanabolic cytokines represents molecular basis inhibiting osteoclastic activity secondary osteoporosis explains part effect ldrnht physical therapy modality key inflammatory disease although reduced acpa levels observed therapy although could potentially contribute osteoprotective effect case rather uncertain reduction minor magnitude
sorts trait information people care forming impressions others recent research social cognition suggests warmth broadly construed prime importance impression formation yet prior research suggests information others specifically moral traits moral character may primary dimension although warmth character sometimes conceived interchangeable argue separable across wide variety contexts character usually important warmth impression formation first showed moral character social warmth traits indeed separable studies studies used correlational experimental methods showed predicted contexts moral character information important impression formation warmth information studies character information also important warmth information respect judgments traits perceived fundamentalness identity uniquely human quality context independence controllability study finally study used archival method show moral character information appears prominently warmth information obituaries strongly determines impressions people form individuals described obituaries discuss implications current theories person perception social cognition
background perfluorooctane sulfonate pfos perfluorooctanoate pfoa two fluorinated compounds widely used industry useful chemical characteristics identified endocrine disruptors due ability interfere thyroid function resistance pfoa pfos environmental degradation bio accumulation food chains long half life raised concern scientific community several studies performed aim establish real dangerousness compounds human health purpose present review focus effects pfoa pfos thyroid gland taking account vitro experiments animal studies human data pfos pfoa reduce circulating levels thyroid hormones diet exposed animals mainly increasing metabolic clearance rate conclusions accumulation pfos pfoa documented thyroid cells cytotoxic effect observed exposure extremely high concentrations compounds environmentally exposed communities general population consistent effect exposure pfoa less extent pfos occurrence hypothyroidism women children appear risk developing mild thyroid failure pregnant women circulating thyroid antibodies might risk developing subclinical hypothyroidism mainly exposed high doses pfos relative risks thyroid cancer people exposed pfoa pfos low based cases moreover consistent finding across even studies
integrity reactor pressure vessel rpv ensured throughout entire life accordance applicable regulations typically assessment rpv brittle failure needs conducted taking account possible loading cases one severe loading cases potentially occur operating time loss coolant accident cold water injected rpv nearly operating conditions high pressure combination thermal shock ferritic pressure vessel wall caused injection cold water leads considerable load belt line area known pressurized thermal shock pts usually assessment brittle failure based deterministic fracture mechanics analysis common parameters like integral stress intensity factor employed calculate load path assumed postulated flaw pts event important input data fracture mechanics analysis transient thermal hydraulics load rpv emergency cooling data calculated analytical fluid mixing codes verified experiments kwu mix numerical computational fluid dynamics cfd tools suitable validation kwu mix standard used calculations within pts analyses rather conservative analytical models quantification mixing depending water level condensation processes downcomer including simplified stripe plume formations utilized contrary numerical cfd tools provide best estimate results due possibility consider realistically stripe plume formations well geometry rpv detail order quantify safety margin inherent standard approach two fracture mechanics analyses rpv beznau based thermal hydraulic input data kwu mix cfd analyses performed subsequently resulting loading paths compared material properties obtained irradiation surveillance program rpv demonstrate exclusion brittle fracture initiation
present study presents new experimental technique measure friction angle soil geosynthetic clay liner gcl method question avoids deficiencies observed inclined plane pullout tests moreover technique allows observing gcl tensile behaviour experimental frame easy build usual geotechnical laboratory one employed made civil engineering department ouargla university algeria usable testing gcls geosynthetic materials also permits apply various experimental conditions like slide velocity confining pressure water content tested materials present method highlights soil gcl interaction actually combination two loading forces soil gcl interface friction pure traction gcl material obtained results allow evaluating soil gcl angle friction intrinsic stiffness gcl relation confining pressure
racial discrimination decision making scenarios police arrests appears violation expected utility theory drawing results science information discuss information based model signal detection population generates behavior alternative explanation taste based discrimination decision maker differences among racial populations model uses decision rule maximizes expected utility likelihood ratio test constrains precision threshold small discrete set precision constraint follows bounded rationality human recollection finite training data estimating priors combined social aspects human decision making precautionary cost settings model predicts race bias observed several econometric studies
concept uncertain pattern mining recently proposed fulfill demand processing databases uncertain data various relevant methods devised however previous approaches following limitations state art methods based tree structure cause fatal problems terms runtime memory usage according characteristics uncertain databases threshold settings tree data structures become excessively large complicated mining processes various approximation approaches suggested order overcome problems however methods increase mining performance cost accuracy mining results order solve problems propose exact efficient algorithm mining uncertain frequent patterns based novel data structures mining techniques also guarantee correctness mining results without false positives newly proposed list based data structures pruning techniques allow complete set uncertain frequent patterns mined efficiently without pattern losses also demonstrate proposed algorithm outperforms previous state art approaches theoretical empirical aspects especially provide analytical results performance evaluation various types datasets show efficiency runtime memory usage scalability method elsevier rights reserved
avulsion fractures ischial tuberosity rare sports injuries typically occurring young athletes misdiagnosis may lead chronic pain disability aim study report retrospective series patients sustaining fracture ischial tuberosity propose decision guidelines mechanism accident diagnostic management mode treatment outcome avulsion fractures ischial tuberosity adolescents analysed thirteen patients female males median age years range years avulsion fracture ischial tuberosity included twelve patients suffered sports injuries leading avulsion fracture five patients displacement treated operatively outcome excellent cases acute presentation osteosynthesis eight patients treated conservatively four showed displacement two patients excellent outcome regular bone healing remaining two patients developed pseudarthrosis associated good outcome present paper shows patients displacement
paper investigate linear superposition principle exponential traveling waves construct sub class wave solutions hirota bilinear equations necessary sufficient condition hirota bilinear equations possessing specific sub class wave solutions presented apply result find wave solutions dimensional equation dimensional generalized kadomtsev petviashvili equation dimensional generalized bkp equation dimensional bkp equation inverse question constructing hirota bilinear equations possessing wave solutions considered refined step algorithm proposed examples construct two general kinds hirota bilinear equations order possessing wave solutions among one satisfies dispersion relation another satisfy dispersion relation
introduction pelvic inflammatory disease pid common serious complication sexually transmitted diseases young women rarely diagnosed postmenopausal women studies done regarding postmenopausal pid determine burden pid associated micro organisms pathophysiology risk factors among post menopausal women community materials methods cross sectional study conducted among post menopausal women registered field practice areas medical college hospital aligarh uttar pradesh india pre designed pre tested proforma used obtain data regarding socio demographic details factors associated pid clinical laboratory examinations done confirm diagnosis pid data analyzed using spss association categorical variables tested chi square test logistic regression analysis used find independent risk factors value considered significant results study subjects diagnosed pid rural areas urban areas bacterial vaginosis followed trichomonas vaginalis common among important risk factors significant association found occupation women increasing parity multiple sexual contacts associated pelvic organ prolapse association smoking chronic illnesses diabetes mellitus hypertension associated urinary tract infection found significant conclusion study shows hidden burden disease community associated risk factors prevented life style cultural changes incorporated earlier lives
chromoblastomycosis chronic fungal infection epidermis dermis subcutaneous tissue common etiologic agent brazil fonsecaea pedrosoi advanced cases found many difficulties treatment therefore report case extensive severe chromoblastomycosis therapeutical failure first choice treatments good response voriconazole
nonlinear behavior often observed structural joint system due external loads new technique nonlinear structural joint model updating static load test results proposed article investigate actual behavior joint system calibrate nonlinear parameters structural joint system appropriate finite element model first established characterize complex nonlinear behavior caused joint connections combined sensitivity analysis parameters describe nonlinear behavior joint connections selected parameters updated subsequently objective function created accordance residual experimentally measured static deflections analytically calculated static deflections finite element model objective function optimized obtain proper values nonlinear force displacement parameters regular simulated annealing algorithm validate efficiency updating approach two numerical examples static concentrated loads conducted obtained results indicate nonlinear joint model parameters successfully updated updated new model forecast true deflections nonlinear structure good accuracy stability
background nursing education process aimed theoretical knowledge skill development fundamentals nursing course furnishes students professional knowledge concepts technical skills also keystone nursing education country students experience great deal anxiety face basic nursing practices first time studies revealed effectiveness music relieving anxiety many patient groups however previous studies found music used intent lower anxiety students experience course skill learning experimental study aimed determining effect music decreasing anxiety first nursing practices students laboratory setting methods experimental study conducted nursing students akdeniz university attending fundamentals nursing freshman course academic year total students assigned experimental group control group participated study data collection carried using student identification form prepared authors skill control lists situational anxiety scale students experimental group listened music blood draw skill practice laboratory environment students assessed respect performance blood drawing skill control lists using statements true false forgotten anxiety levels vital signs students assessed practice results mean age students experimental group control group female age group students experimental group female age group students control group female music listening mean anxiety score students experimental group control group difference mean anxiety scores two groups statistically significant evaluation made blood draw revealed statistically significant difference diastolic blood pressure values experimental group listened music conclusions results study showed listening music decreased anxiety levels nursing students first blood draw experience elsevier ltd rights reserved
background fragile syndrome fxs second cause intellectual disability syndrome prevalent cause intellectual disability males affecting men women caused alteration fmr gene maps band individuals cgg expansion triplets utr gene fmr mutations duplication deletion responsible remaining molecular diagnoses fxs aim review gather current clinical molecular knowledge fxs provide clinicians tool guide initial assessment follow fxs offer laboratory workers researchers update current diagnostic procedures discussion fxs well known condition however studies thus far focused neuropsychiatric features unfortunately available studies limitations paucity patients enrolled bias due collection data single country population may representative average global fxs population recent years insight adult presentation disease progressively increased pharmacological treatment fxs essentially symptom based growing understanding molecular biological mechanisms disease paving way targeted therapy may reverse effects fmrp deficiency real cure disease symptoms conclusions clinical spectrum fxs wide presenting isolated intellectual disability multi systemic condition involving predominantly central nervous system potentially affecting apparatus given relative high frequency condition complex clinical management fxs appears important economic social burden
fulfillment basic psychological needs competence relatedness autonomy believed facilitate people integrative tendencies process psychological conflicts develop coherent sense self present study therefore used event related potentials erps examine relation need fulfillment amplitude conflict negativity neurophysiological measure conflict personal decision making participants completed decision making task made series forced choices according personal preferences three types decision making situations created basis participants unique preference ratings obtained prior erp recording low conflict situations choosing attractive unattractive option high conflict approach approach situations choosing two similarly attractive options high conflict avoidance avoidance situations choosing two similarly unattractive options expected amplitudes larger high relative low conflict situations source localization analyses suggested anterior cingulate cortex generating structure importantly people reporting higher need fulfillment exhibited larger amplitudes avoidance avoidance situations relative low conflict situations lesser extent also exhibited larger amplitudes approach approach situations relative low conflict situations contrast people reporting lower need fulfillment exhibited amplitudes poorly discriminated three decision situations results suggest need fulfillment may promote self coherent functioning increasing people receptivity processing events challenge abilities make efficient self congruent choices
conflicting results reported literature terms usefulness serological testing igg food allergens dogs cutaneous adverse food reaction cafr aim present study evaluate suitability commercially available igg elisa identifying food allergens dogs challenging dogs specific food ingredients selected basis igg reactivity serum samples total adult dogs cafr enrolled study healthy dogs included control group blood samples obtained measurement specific igg antibodies commonly used pet food ingredients elisa participating owners surveyed obtain information pet dietary history eleven healthy control dogs dogs cafr subsequently challenged blinded cross design experiment positive negative food ingredients selected basis elisa test results substantial individual variation elisa test results various food allergens significant difference igg reactivity comparing cafr control groups none control dogs developed clinical signs allergic reaction dietary challenge study cafr group six dogs developed clinical signs negative challenge two nine dogs developed clinical signs positive challenge concluded elisa test dietary allergen specific igg limited value management dogs cafr elsevier ltd rights reserved
indexed data types allow specify verify many interesting invariants finite data general purpose programming language paper investigate dual idea indexed codata types allow describe data dependencies infinite data structures unlike finite data defined constructors define infinite data observations dual pattern matching indexed data may refine type indices define copattern matching indexed codata type indices guard observations make key technical contributions three fold first extend levy call push value language support indexed data deep pattern matching second provide clean foundation dependent pattern matching using equality constraints third describe small step semantics using continuation based abstract machine define coverage indexed patterns prove type safety important step towards building foundation data type definitions dependent types coexist
given matrix size two dimensional range minimum queries rmqs ask position minimum element rectangular range within matrix study trade offs query time additional space used indexing data structures support rmq using novel technique discrepancy properties fibonacci lattices give indexing data structure rmqs uses bits additional space logc log log query time parameter also entries input matrix show query time improved logc space usage published elsevier
paper study suspension bridge equation memory effects suspension bridge equation without memory many classical results existing results mainly devoted existence uniqueness weak solution energy decay solution existence global attractors however existence global attractors suspension bridge equation memory yet considered object present paper provide results well posedness long time behavior suspension bridge equation unique damping mechanism given memory term elsevier inc rights reserved
instability premature charge reversal become major limitations charge reversal delivery systems address problem graft copolymer poly butylene succinate cysteamine poly ethylene glycol pbs peg benzoic imine bond designed synthesized facile thiol ene click reaction subsequent schiff base reaction pbs peg carboxyl functionalized polyester poly butylene succinate mercaptopropionic acid pbs mpa assemble aqueous solution give peg shell sheddable charge reversal micelles sizes low polydispersity interestingly pbs mpa peg micelles could sensitively arbitrarily switch surface charges negative positive status response fluctuation via reversible protonation deprotonation carboxyl amino groups endows desired stability assembly micelles either long term storage physiological conditions doxorubicin dox loaded pbs mpa peg micelles high drug loading content entrapment efficiency result electrostatic attraction vitro release studies revealed less dox released within environment mimicking physiological condition whereas dox released weak acid condition resembling microenvironment endosome lysosome vitro cytotoxicity study suggested blank pbs mpa peg micelles possessed excellent biocompatibility dox loaded pbs mpa peg micelles showed significant cytotoxicity half maximal inhibitory concentration dox equiv study provides facile effective approach preparation novel charge reversal micelles switchable charges excellent biocompatibility highly promising used safe nanocarriers efficient intracellular drug delivery wiley periodicals inc polym sci part polym chem
paper modelling method railway line frequency range khz presented model proposed quantify current voltage harmonics generated traction converters different points network equivalent circuit taking account skin effect time domain simulations also proposed new model based state space representation transfer functions developed simplify study interactions several trains circulating line sector example amplitudes harmonics generated board active rectifiers computed several points network given topology overhead line several positions two trains sector junction
objectives clinical presentation pediatric obsessive compulsive disorder ocd heterogeneous stumbling block understanding pathophysiology developing new treatments major shift psychiatry embodied research domain criteria rdoc initiative national institute mental health recognizes pitfalls categorizing mental illnesses using diagnostic criteria instead rdoc encourages researchers use dimensional approach focusing narrower domains psychopathology characterize brain behavior relationships aim multidisciplinary pilot study use computer vision tools record ocd behaviors cross validate behavioral markers standard clinical measures methods eighteen youths ocd healthy controls completed tasks innovation laboratory free arrangement objects hand washing arrangement objects contrasting carpets tasks video recorded videos coded blind raters ocd related behaviors children yale brown obsessive compulsive scale bocs scales administered compared video recorded measures behavior ocd versus healthy controls correlated video measures clinical measures ocd results behavioral measures videos significantly correlated specific bocs dimension scores free arrangement task time spent ordering objects moves objects significantly associated higher bocs ordering repeating dimension scores longer duration hand washing significantly correlated higher scores bocs ordering repeating forbidden thoughts dimensions arrangement objects contrasting carpets moves adjustment objects significantly associated higher bocs ordering repeating dimension scores conclusion preliminary data suggest measurement behavior using video recording valid approach quantifying ocd psychopathology methodology could serve new tool investigating ocd using rdoc approach objective novel behavioral measurement technique may benefit researchers clinicians assessing pediatric ocd identifying new behavioral markers ocd clinical trial registry development instrument monitors behaviors associated ocd nct http clinicaltrials gov
article applies item response models college computer programming language test according different characteristics programming language test author first get validity discrimination parameter difficulty factor test using classical testing methods based students accuracy answering different examination questions author make use two parameter logistic model get students ability coefficient answering different examination questions mentioned model demonstrated testified basic course test first year students college results beneficial improve teaching activities raising teaching quality
paper describes analyses secure efficient authentication protocol seap designed mobile hoc networks manets seap protocol server coordination based pairwise symmetric key management protocol works hierarchical network architecture supports dynamic membership besides protocol uses passive external membership granting server mgs provide stronger security ensure efficiency protocol uses symmetric key cryptography achieve storage scalability makes use pseudo random function prf protocol also robust authentication server compromise formally proved correctness security guarantees provided seap protocol using strand space verification model evaluated proposed protocol using simulations qualnet simulator experimentations manet testbed simulation experimental study demonstrate effectiveness proposed protocol compared existing approaches
methylation important epigenetic dna modification governs gene expression genomic level methylated dna derivatives may serve important indicators initiation progression cancers among diseases effort propose new laser wrapped graphene array highly sensitive surface enhanced raman spectroscopy sers sensor detection methylated dna methylcytosine oxidation derivatives namely hydroxymethylcytosine hmc carboxylcytosine cac excellent sensitivity reproducibility achieved laser wrapped graphene array substrate graphene layer acting enhancer sers signal due effective coupling electromagnetic field summary fast less min sensitive limit detection pmol detection methylated dna derivatives realized ability distinguish methylation levels mixture sensitive accurate detection dna extracted cells also accomplished furthermore graphene wrapped approach circumvents direct interaction array analytes thus improving reusability sers substrate even five cycles use
objectives investigate influence internalized weight stigma iws physical activity outcomes among women body mass index bmi design method data drawn rct included primarily inactive women nonhispanic latina white mean age range mean bmi range participants completed month weight neutral health every size weight loss focused group based healthy living program enjoyment engagement moderate intensity least minutes days week assessed baseline immediately post intervention used intention treat linear mixed effects modeling test iws moderator changes engagement also tested model whereby positive effects participating program engagement would serially mediated reduction iws concomitant increase enjoyment results weight neutral weight loss focused data combined analyses moderation hypothesis supported significant interaction iws time participants significant gains overall engagement baseline post intervention however high iws attenuated response serial mediation model also supported positive effect program engagement occurred decreased iws increased enjoyment conclusions self directed stigma holding negative attitudes one weight interferes positive changes outcomes healthy living programs may less effective vulnerable unless aim reduce iws elsevier ltd rights reserved
review argue favour integration disciplines positive clinical psychology argue constructs studied positive clinical psychology exist continua ranging positive negative gratitude ingratitude anxiety calmness meaningless speak one field studying positive negative however highlight historical cultural factors led positive clinical psychologies focus different constructs thus difference fields due constructs study rather inherently positive negative argue much benefit clinical psychology considering positive psychology constructs constructs studied positive psychology researchers independently predict wellbeing accounting traditional clinical factors cross sectionally prospectively constructs studied positive psychologists interact risk factors predict outcomes thereby conferring resilience interventions aim increase movement towards positive pole well used encourage movement away negative pole either isolation alongside traditional clinical interventions research positive psychology support clinical psychology seeks adapt therapies developed western nations cultures
idiopathic pulmonary fibrosis ipf chronic progressive ultimately fatal disorder cure disease definition idiopathic accumulating evidence including familial aggregation cases occurrence pulmonary fibrosis context number rare genetic disorders indicates genetic factors contribute significantly pathogenesis ipf several disease associated genetic variants rare common identified familial sporadic ipf full clinical implications genetic associations remain elucidated observational studies suggest genotype influences development disease outcome available data indicate genetics potential identify individuals risk ipf classify patients precisely clarify key pathways involved disease pathogenesis eventually develop effective targeted therapies considerable research required comprehensive disease fingerprint ipf delivered nevertheless application rapidly evolving molecular biology genomic technologies combined appropriate bioinformatic methodology offers unprecedented realistic opportunity achieve goal
investigate renal function idiopathic hypogonadotropic hypogonadic ihh patients measuring glomerular filtration rate gfr using modification diet renal disease formula determine whether relationship gfr testosterone levels thirty three patients ihh healthy control subjects participated study ihh group showed statistically significant higher gfr proteinuria respect control group min respectively uric acid creatinine levels statistically lower control group respectively hyperfiltration positively correlated ihh multivariate linear regression analyses beta addition ihh group found gfr increased independently body mass index age study confirms low testosterone ihh patients associated glomerular hyperfiltration patients ihh carefully monitored respect gfr
nonlinear methods deep neural networks dnns gold standard various challenging machine learning problems image recognition although methods perform impressively well significant disadvantage lack transparency limiting interpretability solution thus scope application practice especially dnns act black boxes due multilayer nonlinear structure paper introduce novel methodology interpreting generic multilayer neural networks decomposing network classification decision contributions input elements although focus image classification method applicable broad set input data learning tasks network architectures method called deep taylor decomposition efficiently utilizes structure network backpropagating explanations output input layer evaluate proposed method empirically mnist ilsvrc data sets
background aimscognitive impairment associated excessive alcohol use neural basis poorly understood chronic excessive alcohol use adolescence may lead neuronal loss volumetric changes brain objective compare grey matter volumes heavy light drinking adolescents designthis longitudinal study heavy drinking adolescents without alcohol use disorder light drinking controls followed years using questionnaires three time points magnetic resonance imaging conducted last time point settingthe area near kuopio university hospital finland participantsthe participants aged years included alcohol users controls followed approximately years measurementsalcohol use measured alcohol use disorders identification test audit three time points years participants selected based audit score magnetic resonance imaging conducted last time point grey matter volume determined compared heavy light drinking groups using voxel based morphometry three dimensional weighted magnetic resonance images using predefined regions interest threshold small volume correction applied cluster level findingsgrey matter volumes significantly smaller among heavy drinking participants bilateral anterior cingulate cortex right orbitofrontal frontopolar cortex right superior temporal gyrus right insular cortex compared control group family wise error corrected cluster level conclusionsexcessive alcohol use adolescence appears associated abnormal development brain grey matter moreover structural changes detected insula alcohol users may reflect reduced sensitivity alcohol negative subjective effects
background families children affected atopic dermatitis often report fear anxiety regarding treatment topical corticosteroids tcs may lead reduced compliance objective study measure standardized questionnaire fear tcs families pediatric patients identify items associated fear methods families pediatric patients enrolled italian centers pediatric dermatology enrolled parents invited fill questionnaire including questions sociodemographic clinical characteristics sets questions corticosteroid phobia general fear specific fears behaviours regarding tcs determinants level general fear investigated multivariable analysis results total outpatients enrolled parents high instruction level eighty one percent reported certain amount fear tcs multivariable analysis fear tcs associated following items believing tcs treatment advantages overweight disadvantages believing tcs may dangerous independently specific side effect moreover tcs fear associated fear applying much cream conclusion tcs phobia widespread among italian families children fear tcs associated fear applying much cream thus increasing risk poor compliance treatment failure therapeutic education families use tcs implemented
unified protocol transdiagnostic treatment emotional disorders cognitive behavioral intervention designed treat range anxiety depressive related disorders thus far treatment modules studied delivered entirety presented standard sequence personalize presentation modules given patient presentation providing modules varied order dropping irrelevant modules first necessary establish module leads change skill designed promote changes occur absence modules using multiple baseline design accordance single case reporting guidelines behavioral interventions scribe eight patients heterogeneous emotional disorders randomly assigned week baseline assessment phase followed four sessions one four modules psychoeducation emotional awareness cognitive flexibility countering emotional behaviors results provide preliminary support notion module study leads change associated skill absence modules five eight patients demonstrated reliable change module specific skill addition exploratory analyses suggest emotion awareness training cognitive flexibility modules appeared exhibit change specific associated skills psychoeducation countering emotional behaviors demonstrated somewhat broad based change across skills
anomaly outlier object exhibiting differences suggest belongs yet undefined class category early detection anomalies often proves great importance may correspond events fraud spam device malfunctions automating creation ranking list deviations save time decrease cognitive overload individuals groups responsible responding events years many anomaly outlier metrics developed paper propose clustering based score ensembling method outlier detection using benchmark datasets evaluate quantitatively robustness accuracy different ensemble strategies find ensembling strategies offer limited value increasing overall performance provide robustness negating influence severely underperforming models elsevier rights reserved
objectives describe three methods used screen frameshift mutations exon calr gene methods genomic dna patients extracted peripheral blood bone marrow using dna blood kit qiagen valencia quantified quant picogreen dsdna assay kit invitrogen san diego clinical history cytogenetics molecular tests patients diagnosed either clonal nonclonal hematologic diseases calr screening primarily performed using fragment analysis polymerase chain reaction next generation sequencing sanger sequencing results among patients diagnosed clonal diseases one acute myeloid leukemia positive trisomy myeloproliferative neoplasms mpns including chronic myeloid leukemia cml essential thrombocythemia primary myelofibrosis pmf polycythemia vera patients cml positive bcr abl fusion ten patients positive jak pmf three calr positive pmf patients diagnosed nonclonal disease negative jak bcr abl calr mutations conclusions screening calr mutations essential bcr abl negative mpns since provides valuable diagnostic prognostic information also identifies potential treatment targets since study describes importance screening known novel biomarkers described detail three methods could easily integrated clinical laboratory
patient male final diagnosis hepatitis symptoms icterus medication clinical procedure specialty endocrinology metabolic objective unusual clinical course background chronic hepatitis virus hcv infection associated increased insulin resistance risk type diabetes successful antiviral treatment improve insulin resistance allow reduction blood glucose lowering treatment case reports reduced insulin requirement situation although case insulin stopped exhibited subsequent deterioration glycemic control case report year old italian man diagnosed hcv infection age years type diabetes years later started metformin progressed multiple daily insulin injections years treated pegylated interferon ribavirin telaprevir months early achieved sustained virologic response normalization hepatic function within months starting therapy subsequently able reduce insulin doses day next years based random serum peptide nmol fasting reference range nmol presence serum glucose mmol negative glutamic acid decarboxylase antibodies accelerated withdrawal stopped insulin months later currently taking linagliptin daily good glycemic control body mass index hba remained mmol mol respectively throughout conclusions case shows complete withdrawal long term insulin therapy may possible hcv treatment induced sustained virologic response
objective search scientific literature nursing diagnoses identified adult elderly patients undergoing antineoplastic chemotherapy outpatient setting methods review studies published portuguese english spanish searched five electronic databases march using descriptors nursing process nursing diagnosis neoplasms drug therapy hospital outpatient clinic results four studies selected review nursing diagnoses identified namely unbalanced nutrition less body requirements risk deficient fluid volume diarrhoea fatigue impaired home maintenance deficient knowledge disturbed body image interrupted family processes ineffective sexuality pattern anxiety powerlessness fear readiness enhanced religiosity risk infection impaired dentition risk impaired skin integrity acute pain nausea conclusions nursing diagnoses identified support selection interventions creation nursing guidelines outpatient oncology services
linux based operating systems runtimes emerged environments choice majority hpc systems linux based advantages extensive feature sets developer familiarity features come cost additional system overhead contrast linux substantial history work hpc community focused lightweight provide scalable consistent performance hpc applications lack many features offered commodity paper propose bridge gap lwks commodity selectively providing lightweight memory subsystem hpc applications commodity concurrently executing diverse range workloads commonplace system hpmmap provides lightweight memory performance transparently hpc applications bypassing linux memory management layer using hpmmap hpc applications achieve consistent performance local compute nodes execute competing workloads likely found hpc clusters situ workload deployments approach dynamically configurable runtime requires resources use show hpmmap decrease variance reduce application runtime percent executing located competing commodity workload
present paper reports trial shed light characterization applications operation radar speed guns gunn diodes different radiation environments neutron gamma fields end theoretical experimental investigations microwave oscillating system outer space applications carried radiation effects transient parameters electrical properties proposed devices studied detail application computer programming also oscillation parameters power characteristics bias current plotted influence different gamma neutron irradiation levels finally shelf oven annealing processes shown satisfactory techniques recover initial characteristics irradiated devices copyright published elsevier korea llc behalf korean nuclear society
metabolomics emerging new omics field involving systematic analysis metabolites biologic system metabolites provide molecular snapshot cellular activity thus important understanding functional changes metabolic pathways drive disease recently metabolomics used study local systemic metabolic changes psoriasis cardiometabolic comorbidities studies revealed novel insights disease pathogenesis suggest new biochemical signatures may used marker psoriatic disease review discuss common strategies metabolomics analysis current findings metabolomics psoriasis emerging trends psoriatic metabolomics
background functional somatic symptoms fss symptoms without clear medical explanation considerable challenge health care systems general consensus symptoms regarded functional longitudinal studies development fss exist mainly based assumption factorial structure fss scores variable remains invariant time analysis covers longer periods life course may challenged aim study investigate ten functional somatic symptoms fss evolve individuals ageing methods data northern swedish cohort questionnaire surveys ages analysed participation rates remained high five surveys list symptoms included backache breathlessness dizziness fatigue headache migraine nausea overstrain palpitations sleeplessness stomach ache used multivariate trajectory analysis logistic broken stick regression models describe sub groups data multivariate joint development set item variables investigated need construct special fss summary score variable results four well separated trajectories identified two groups healing symptoms sample low symptom load sample symptom level stayed relatively low adulthood third group high symptom load probability symptoms high fss variables fourth group increasing symptoms level symptoms first intermediate increased markedly age conclusions instead single fss score able assign individual one four trajectories described jointly separate symptoms profile development probability level rather similar symptoms within trajectories exceptions results provide better understanding longitudinal development symptoms adolescence middle age
land degradation environmental impacts major impediments utilization land many arid semiarid regions world major issue northwestern sinai nws egypt monitoring detecting land use land cover changes land degradation important planners governments scientific communities particularly increasing pressures human natural activities adjacent environment water logged saltaffected soils coastal erosion sand dunes encroachment serious environmental hazards resulting wasteland geoenvironmental risks presently attempts made analyze determine changes nws present work utilizes image processing gis techniques determine causes result intensive land degradations recommends appropriate remedial measures within nws multi temporal remote sensing data aster gdem used map change areas many image processing techniques statistical analysis applied draw numerous thematic geospatial distribution maps degraded lands results showed rapid change attributed human activities led heavy deteriorations nws environment also prevalence natural risk corresponding coastal erosion water level rising sand dunes encroachment increase susceptibility hazards nws area current study provides decision makers resources managers appropriate remedial measures necessary avoid severe future environmental difficulties within nws
economic performances consecutive multi span suspension bridges studied material amount cost estimation formulas bridges derived part study parametric study carried based formulas investigating different factors effect bridge cost factors include bridge sag bridge span bridge foundation environment condition etc economical layout bridges proposed different conditions lastly selection suspension bridge types discussed based economy bridges
approximately ischemic strokes associated atrial fibrillation first diagnosed time stroke detecting asymptomatic would provide opportunity prevent strokes instituting appropriate anticoagulation screen international collaboration formed september promote discussion research screening strategy reduce stroke death provide advocacy implementation country specific screening programs expert members screen including physicians nurses allied health professionals health economists patient advocates invited prepare sections draft document august members met rome discuss draft document consider key points arising using delphi process key points emphasize screen detected found single timepoint intermittent ecg recordings weeks benign condition additional stroke factors carries sufficient risk stroke justify consideration anticoagulation regard methods mass screening handheld ecg devices advantage providing verifiable ecg trace guidelines require diagnosis would therefore preferred screening tools certain patient groups recent embolic stroke uncertain source esus require intensive monitoring settings screening include various venues community clinic must linked pathway appropriate diagnosis management screening effective recognized health resources vary widely countries health systems setting screening country health system specific based current knowledge white paper provides strong case screening recognizing large randomized outcomes studies would helpful strengthen evidence base
purpose evaluate perceived effectiveness key antismoking messages among highly disadvantaged smokers assess impact nicotine dependence cessation cognitions message processing design experimental crossover trial undertaken march december randomly exposed participants two three antismoking advertisements delivered via touchscreen computer setting welfare recipients recruited community service organization new south wales australia subjects subjects smokers response rate participants resided government rental housing earned less aud received primary income government welfare intervention three second antismoking television advertisements representing common campaign themes quit graphic imagery quit personal testimonial quit measures item scale assessed perceived effectiveness message acceptance eight item cessation cognitions index assessed motivations readiness quit heaviness smoking index used classify nicotine dependence analysis descriptive statistics generalized linear mixed models multiple linear regression analyses reported results quit advertisements perceived significantly effective quit advertisement smokers positive cessation cognitions likely accept antismoking messages perceive effective nicotine dependence level influence message acceptance effectiveness conclusion highly emotive advertisements providing good reasons quit may effective promoting antismoking message among groups high smoking rates
growing public concern environmental pollution emitted conventional thermal power plants result priority given development clean energy leads less pollution fewer emissions environment hydropower clean renewable energy plays critical role mitigate environmental issues associated power generation industry paper presents theoretical analysis hydropower generators comprehensive manner including environmental technological perspectives via multiple methods theory inventive problem solving triz life cycle assessment lca sensitivity analysis study aims investigate sustainable development path hydropower provides useful inputs select appropriate type generator according status quo product development special attention environmental performance results show evaporative cooling generator better choice less greenhouse gas emission total kwh air cooling generator total kwh according evaluation technology readiness scenario analysis advancement technology also make contribution economic development findings useful policy making choosing appropriate type cooling system well hydropower system elsevier ltd rights reserved
food quality safety significant pressing issue recent years light fao definition food security physical social economic access sufficient nutritious food food safety plays fundamental role animal feed feeding pivotal livestock industry use veterinary antibiotics vas synthetic growth promoters sgp diminishes sustainability diets cause accumulation residues animals meat milk eggs environment water soil pollution wastewater systems another major pathway antibiotics hormones enter environment negative consequences order protect planet sustainable feeding reduction antibiotics synthetic growth promoters key aim particular goal reducing antibiotic resistance allergies analytical methods play crucial role food analysis determine presence antibiotics additives recent methods based liquid chromatography ultraviolet fluorescence mass spectrophotometry detection recognized essential technique food analysis able identify compounds feed samples general monitoring program put place educate population hazards residues animal products necessary conjunction continuous decrease use antibiotics synthetic growth promoters animal diets elsevier ltd rights reserved
wake green building revolution india buildings attempting build certify green rating systems applicable certification evaluate buildings based upon established criteria ranging building envelope water efficiency energy efficiency landuse material optimization indoor air quality transport operations maintenance etc however credit awarded spatial design achieving efficiency response issue new evaluation tool evolved namely difference uncomfortable hours outside inside tool evaluated building response climate placed simple terms thermal conditions outside building compared thermal conditions created inside due design however use duhoi established tool evaluating efficiency architectural design bringing thermal comfort bandwidths climatic zone set done evaluating best examples also seemingly bad examples based upon understanding passive architecture research work limited establishing bandwidth duhoi hot dry climate india range buildings hot dry climatic zone identified simulated using whole building simulation tool duhoi calculated building manner benchmark set buildings aspiring green building certification would work architectural design efficiency prerequisite would lead overall improvement building performance
resistance distance two vertices connected graph defined effective resistance electrical network constructed graph replacing edge unit resistor let circle times boxed times degrees join product composition direct product strong product corona rooted product two graphs respectively paper formulae resistance distances composite graphs given terms parameters parent graphs properties established explicit formulae obtained resistance distances classes graphs including rook graphs diagonal mesh graphs generalized double graphs
introduce self consistent approach description nonlinear light propagation inas ingaas quantum dot semiconductor optical amplifiers using numerically analyze four wave mixing conversion efficiency amplifiers approach based delay differential equation optical field propagating amplifier additional equations describing microscopically calculated charge carrier dynamics quantum dot states surrounding quantum well reservoir draw attention studies hierarchy nonlinear effects involved four wave mixing processes observe spectral hole burning important effect drive four wave mixing charge carrier density pulsation appearing together spectral hole burning constitutes second important effect charge carrier heating turned negligible furthermore found four wave mixing conversion efficiency effectively increased higher device pump current higher device temperature used provided frequencies injected light sources adjusted temperature dependent gain maximum
automated identification markers medical imaging one issues proposed recent years many tasks wide application digital image analysis universal algorithm introduce low computational cost system based radon transform determine markers watershed segmentation purposes nearly circular structures grey scale images red blood cells images obtained optical light microscopy blood smears search markers performed based ability detect shape parameters characterise behaviour circular structures circular structure edge determined previously order apply direct sinogram projections filtered utilising matched filter image peaks close circular structures centres obtained means reverse threshold calculated applied order identify markers reached precision comparable results within state art measure
social life hinges ability infer others mental states default people often recruit self knowledge social inference particularly others similar oneself people active perspective taking efforts deliberately imagining another perspective affect self knowledge use experiments test flexible self application hypothesis application self knowledge perspective taking target differs based person similarity oneself found consistent evidence making inferences dissimilar others perspective taking increased projection one traits preferences targets relative control condition making inferences similar others however perspective taking decreased projection findings suggest self target similarity critically shapes inferential processes triggered active perspective taking efforts
measuring apertures large hadron collider lhc collimators well positions axes challenging task lhc collimators equipped high precision linear position sensors linear variable differential transformers lvdts accuracy sensors limited peculiar parasitic effect rather sensitive external magnetic fields new type inductive sensor ironless inductive position sensor ips keeps advantages lvdts insensitive external magnetic fields designed constructed tested cern sensor detailed description parasitic effects high frequency capacitances presence conductive shields electric motor surroundings given analytical numerical experimental viewpoints addition proof given ips radiation hardness aim paper give complete exhaustive impact evaluation metrological viewpoint parasitic effects two fundamental sensor solutions
one main public concerns aquatic habitat corresponding issues incessant contamination ecological water systems recent years research attention focused processes lead improved oxidative degradation organic pollutants therefore semiconductor photocatalysis technology aroused scientists interest environmental remediation although several semiconductors proven ideal candidates treatment water pollution efficient separation recycling fine powdered photocatalyst still scientific problem applied practice including separation process selectivity dispersion photocatalyst magnetic properties allows use technique magnetic separation one effective simple methods removing suspended solids wastewater without need separation processes magnetic photocatalyst allows use suspended material providing advantage high surface area reaction review highlights advantages disadvantages current photocatalyst systems moreover focuses hybrid magnetic photocatalysts including metals nonmetals metal oxides carbon based materials ceramics
article presents vision based formation flight control aerial robots special focus failure conditions visual communication proposing combining two strategies new solution presented formation control vision based formation flight state variables leader estimated using image processing unscented kalman filter follower adjusts position respect leader based results estimation case visual communication failure error occur estimation variables would increase decreased image quality first proposed strategy failure emergence position follower aerial robot obtained combining unscented kalman filter estimated velocity vector velocity vector failure weighting coefficient velocity vector obtained fuzzy logic based image quality second strategy reduce possibility collision members geometry formation pattern expanded function image quality distance members expansion coefficient also extracted fuzzy inference method desired distance members increased function expansion coefficient two strategies combined used failure periods finally simulation studies presented conducted based system nonlinear equations model degrees freedom member proposed visual noise model obtained results reveal proper capability proposed hybrid strategy terms controlling formation flight failure conditions
objective although emerging western industrialized societies limited research exists links housing health outcomes persons living hiv aids plwhas sub saharan africa ssa methods using survey data collected plwhas lower manya krobo district ghana paper examined effects housing structure arrangements accessibility conditions physical psychological emotional health respondents results results indicate housing variables independent effects health outcomes controlling socio economic demographic variables respondents living poor housing structures deplorable housing conditions poorer physical psychological health scores conclusion findings suggest relevant think houses occupied plwhas important sources health inequality
background previous studies reported varying return sport protocols knee cartilage restoration procedures purpose evaluate time return sport athletes isolated chondral injury underwent accelerated return sport protocol osteochondral autograft plug transfer oat evaluate clinical outcomes assess consequences accelerated return sport study design case series level evidence methods institutional cohort oat procedures reviewed competitive athletes met inclusion exclusion criteria patients underwent physician directed accelerated rehabilitation program procedure return sport determined athletes clinical outcomes assessed using international knee documentation committee ikdc tegner scores well assessment level participation return sport results return sport data available athletes athletes available clinical evaluation mean year follow mean time return sport athletes days range days athletes able return sport previous level reported satisfied satisfied surgical outcome ability return sport mean postoperative ikdc score mean tegner score prior injury final follow conclusion competitive athletes traumatic chondral defects treated oat managed using protocol reduced time preinjury activity levels compared currently reported excellent clinical outcomes serious long term sequelae
paper present mixed reality environment mixer immersive interactions mixer agent based collaborative information system displaying hybrid reality merging interactive computer graphics real objects mixer agent based collaborative information system displaying hybrid reality merging interactive computer graphics real objects system comprises sensor subsystem network subsystem interaction subsystem related issues concept mixed interaction including human aware computing mixed reality fusion agent based systems collaborative scalable learning distributed systems qoe qos balanced management information security discussed propose system architecture perform networked mixed reality fusion ambient interaction components mixed reality suit perform human aware interaction interaction space motion monitoring action scenario synthesisers script generator knowledge assistant systems scenario display mixed reality module thus mixer integrated system provide comprehensive human centered mixed reality suite advanced virtual reality augmented reality applications therapy training driving simulations
study investigated desensitization violence short period time participants watched nine violent movie scenes nine comedy scenes reported whether enjoyed violent comedy scenes whether felt sympathetic toward victim violence using latent growth modeling analyses carried investigate participants responded different scenes across time findings study suggested repeated exposure media violence reduces psychological impact media violence short term therefore desensitizing viewers media violence result viewers tended feel less sympathetic toward victims violence actually enjoy violence portrayed media additionally desensitization media violence better represented curvilinear pattern whereas desensitization comedy scenes better represented linear pattern finally trait aggression related pattern change time although significant effects found initial reports enjoyment sympathy aggr behav wiley liss inc
objective evaluate respiratory function post operative early period patients undergoing bariatric surgery using sleeve gastrectomy technique methods prospective observational study conducted bulent ecevit university health application research centre zonguldak turkey june december comprised patients planned bariatric sleeve gastrectomy general anaesthesia participants visited hours operation record accompanying diseases demographic data operations respiratory function test maximum expiratory pressure maximuminspiratory pressure arterial blood gas assessment tests done recorded one hour operation aldrete scores mentioned tests repeated recorded spss medcalc used statistical analysis results participants women men overall median age years inter quartile range years mean median values forced expiratory volume second forced vital capacity maximum inspiratory pressure maximum expiratory pressure ratio partial pressure oxygen arterial blood fraction inspired oxygen interquartile range interquartile range respectively compared interquartile range interquartile range also participants given sugammadex given neostigmine end test sugammadex odds ratio confidence interval pre operative ratio partial pressure oxygen arterial blood fraction inspired oxygen odds ratio confidence interval found correlate significantly conclusion impairment respiratory function found early post operative period
many pathogens present human environment immunocompromised patients cause extremely severe opportunistic infections patients suffering immunological disorders rarely treated maxillo facial departments special cases require direct clinical approach fungal infections cranio facial area occur often opposed infections bacterial flora frequently found special conditions requirements needed present occurrence fungal infections found many treated locally antifungal medicaments require additional radical surgical excisional approach mucor one infections related mucormycosis zygomycosis rhinocerebral zygomycosis particularly dangerous rare cranio facial infection great challenge clinicians surgeons seems accurate proper diagnosis impact patient survival post treatment quality life paper focus recent clinical findings treatment methods disease
proteomics large scale analysis proteins proteomic techniques liquid chromatography tandem mass spectroscopy lcms characterize thousands proteins time powerful techniques allow systemic understanding cellular changes especially cells subjected various stimuli infections stresses specific test conditions even recent developments analyzing exosomal proteome time consuming often involves complex methodologies addition resultant large dataset often needs robust streamlined analysis order researchers perform downstream studies describe silac based protocol characterizing exosomal proteome cells infected hiv method based simple isotope labeling isolation exosomes differentially labeled cells mass spectrometry analysis followed detailed data mining bioinformatics analysis proteomic hits resultant datasets candidates easy understand often offer wealth information useful downstream analysis protocol applicable subcellular compartments wide range test conditions
new current mode squaring circuit used basic building block analog signal processing systems proposed design based mos operating subthreshold region assure low voltage low power consumption performance design confirmed hspice simulation cmos process circuit operated supply voltage consumes maximum linearity error
simulations practical reliable approach power calculations especially multi level mixed effects models analytic solutions complex addition power calculations model specific multi level mixed effects models defined plethora parameters words model variations context numerous tailored algebraic calculations article describes ipdpower stata new simulations based command calculates power mixed effects two level data structures although command developed individual patient data meta analyses primary care databases analyses mind patients nested within studies general practices respectively methods apply two level structure
study explored extent neural correlates affective personality influence face processing using event related potentials erps learning phase participants viewed target individual face expression neutral faint smile paired either negative neutral positive sentences describing previous typical behavior target following eeg testing phase participants completed gender judgments learned faces statistical analyses conducted measures neural activity gender judgment task repeated measures anova frp data showed faces described negative personality elicited larger neutral positive description early posterior negativity epn showed result pattern larger amplitudes faces paired negative personality others size late positive potential larger faces paired positive personality neutral negative personality current study indicates affective personality information associated automatic top modulation face processing
context software system structure often degrades due repetitive maintenance make sustainable evolution systems becomes mandatory improve modular structure certain time many remodularization approaches proposed improve modular structure software systems existing approaches rely structural lexical dependencies however lack research distinguishes different types structural inheritance method calls references etc lexical name classes methods variables etc dependencies assumes equivalent illogical software developer point view objective paper propose approach considers various types structural well lexical dependencies along relative importance remodularize object oriented systems main goal paper generate remodularization solutions reflect developers perspective visible well modularized software system remodularization highly desirable software evolution method paper computes coupling strength among classes using different weights computed basis well modularized software system terms various mechanisms structural lexical dependencies software remodularization problem formulated single multi objective optimization problem solved using genetic algorithnis based different types structural lexical dependencies per weighted weighted variants designed following coupling schemes structural based sbuw sbw sauw saw stfuw stfw stfidfuw stfidfw lexical based lbuw lbw lauw law ltfuw ltfw ltfidfuw ltfidfw combined structural lexical based slbuw slbw slauw slaw sltfuw sltfw sltfidfuw sltfidfw values obtained coupling schemes used coupling cohesion objective function along objective supportive objective functions mci msi used drive optimization process towards good quality modularization solution results assess effectiveness proposed remodularization approach eight real world object oriented software systems terms original design experimented software systems modularization decisions provided developers results indicate tfidf based weighted variants stfidfw ltfidfw sltfidfw broad three categories outperformed rest variants within category however tfidf weighted variant third broad category sltfidfw outperformed others conclusion combined lexical structural approach sltfidfw considering various types dependencies along relative weights performs well results better remodularization compared rest considered alternates also shows significant improvement techniques based lexical structural information thus approach useful improve quality software whose remodularization quality deteriorates beyond accepted level elsevier rights reserved
knowledge existing casting parameters like casting speed casting temperature steel ingot ratio main precondition minimize well known defects steel ingots especially demanding metallurgical conditions appropriate apply method numerical modelling using available simulation software within project named regional materials science technology centre technical background department metallurgy department physical chemistry theory technological processes faculty metallurgy materials engineering fmme vsb technical university ostrava extended workplace laboratory modelling processes liquid solid phases laboratory equipped new commercial simulation software intended numerical simulation molten steel flow filling metal mould subsequent steel solidification prediction macrosegregation residual stress leading cracks correct parameter setting calculation preparation geometry input values heat transfer coefficients material properties definition filling time necessary condition obtaining relevant results numerical modelling paper deals testing optimizing conditions numerical model settings simulation steel ingot casting solidification environment newly acquired commercial simulation software procast conclusion summarizes obtained knowledge listed fields research contribute deepening long term beneficial cooperation commercial sphere fmme
exposure testosterone critical period prenatal development disrupts normal display sexual behaviors adult ovariectomized ovx rats treated estradiol benzoate followed progesterone organizational hypothesis posits prenatally androgenized females pnafs desensitized tested hypothesis first treating pnafs varying doses followed second subjecting females established behavioral sensitization paradigm females first given sexual experience prior repeated sexual behavior testing alone long evans females androgenized utero injection testosterone propionate oil control pregnant dams gestational day female offspring ovx postnatal day tested one week later unilevel hole pacing chamber genital tissue defeminized phafs lordosis quotient partial hops darts full solicitations significantly lower defensive behaviors higher pnaf females relative non pnaf females regardless acute priming dose however repeated testing alone eliminated differences groups hops darts indicating behavioral deficit overcome sexual experience results suggest phafs desensitized despite disruptions sexual differentiation anatomical structures deficiency sexual behavior response acute experientially overcome phafs appear however chronic deficit expression full solicitations elsevier inc rights reserved
influence day length living creatures differs photosensitivity creature however possible sunshine duration might inadequate index photoperiod creatures low light sensitivity address issue authors tried estimate effective day length duration photoperiod exceeds certain threshold light intensity continual global solar radiation observation data gathered baseline surface radiation network bsrn sites converted illuminance data using luminous efficiency model monthly average daily photoperiods exceeding defined intensity calculated defined lux relationships monthly average global solar radiation lux investigated low light intensity lux showed logarithmic relationship using relationships empirical models derived estimate effective day length different light intensities according validation model effective day length light intensity could estimated accuracy less mean absolute percentage error mape estimation monthly base photoperiod recently number studies provided support link day length diseases results useful assessing relationships day length diseases
purpose study determine incidence rate injuries risk injury first year students human movement sciences program university costa rica school year prospective study students voluntarily completed informed consent self report questionnaire determine injuries physical activity habits participants instructed every monday semester report injury occurred previous week make doctor appointment accurate diagnostic results indicated first year students women men entered program already injured follow year student population reported new injury new lesions women men knee thigh frequent injuries lesions occurred mainly extracurricular context injury risk population incidence rate injuries exposure conclusion first year male female student population human movement sciences program university costa rica vulnerable injuries lower body greater number injuries second semester year longitudinal studies needed determine evolution care injuries throughout program
occurrence substance use disorders suds posttraumatic stress disorder ptsd extremely common associated elevated dropout relapse rates given ptsd sud occurrence rates among veterans found high important identify mechanisms may affect interplay disorders emotion dysregulation presents candidate mechanism may underlie poor treatment response occurring ptsd sud article proposes transdiagnostic emotion regulation framework considers conceptualized combination low ability tolerate emotional distress low distress tolerance difficulties goal directed use emotion regulation strategies key risk factor occurring ptsd sud authors review empirical findings self report laboratory based studies ptsd describe psychological explanations emotion substance relationship review studies documenting suds occurring ptsd sud literature ptsd sud suggests patients ptsd may resort substances cope trauma related symptoms due may maintain sud symptoms interfere psychological treatment longitudinal studies bidirectional relationships substance use ptsd needed particularly research examining course ptsd patients use substances versus
objectivesmen sex men msm risk genital warts anal cancer due human papillomavirus hpv infection study explores msms perceptions hpv hpv vaccination prior introduction programme designfocus groups one one interviews self identified msm conducted november march brighton methodsparticipants recruited community based lesbian gay bisexual transgender lgbt venues organizations discussions recorded transcribed verbatim analysed using framework analysis resultsthirty three men took part median age years iqr know hpv anal cancer hpv vaccination genital warts anal cancer perceived severe men perceive risk hpv msm would accept hpv vaccine offered health care professional challenges accessing sexual health services openly discussing sex experiences health care professionals perceived barriers accessing hpv vaccination two participants concerned selective hpv vaccination could increase stigma prejudice msm comparable aids epidemic ten msm unsure effectiveness hpv vaccination sexually active men favour vaccinating adolescent boys school conclusionsmost msm poor knowledge hpv associated anal cancer despite lack concern hpv msm expressed willingness receive hpv vaccination need health education risks hpv hpv related diseases msm appraise benefits vaccinated concerns hpv vaccine effectiveness sexually active men possible stigmatization need addressed optimize hpv vaccine acceptability
introductionthe coagulopathy cirrhosis complex placing patients risk bleeding thrombosis direct oral anticoagulants doacs equivalent superior efficacy safety compared vitamin antagonists vkas however efficacy safety liver cirrhosis studied better define evaluated outcomes patients cirrhosis prescribed doacs compared anticoagulants center methodsretrospective cohort study patients cirrhosis prescribed therapeutic anticoagulation year period thrombosis prevention stroke patients atrial fibrillation primary outcomes interest bleeding events recurrent thrombosis stroke resultsduring study period patients cirrhosis prescribed doac prescribed vka low molecular weight heparin lmwh groups similar total bleeding events doac significantly less major bleeding episodes doac group recurrent thrombosis occurred one patient receiving doac one patient receiving anticoagulation conclusionsdirect oral anticoagulant use patients cirrhosis may safe traditional anticoagulants patients cirrhosis center prescribed doacs less major bleeding events maintaining efficacy preventing stroke thrombosis
clinical data comprised large number synchronously collected biomedical signals measured different locations deciphering interrelationships signals yield important information dependence providing useful clinical diagnostic data instance computing coupling near infrared spectroscopy signals nirs systemic variables status hemodynamic regulation mechanisms assessed paper introduce algorithm decomposition nirs signals additive components algorithm signal decomposition base obliques subspace projections side obsp assumes measured nirs signal linear combination systemic measurements following linear regression model epsilon side obsp decomposes output component decomposition represents sole linear influence one corresponding regressor variable decomposition scheme aims providing better understanding relation nirs systemic variables provide framework clinical interpretation regression algorithms thereby facilitating introduction clinical practice side obsp combines oblique subspace projections obsp structure mean average system order define adequate signal subspaces guarantee smoothness estimated regression parameters observed normal physiological processes impose tikhonov regularization using matrix differential operator evaluate performance side obsp using synthetic dataset present two case studies field cerebral hemodynamics monitoring using nirs addition compare performance method system identification techniques first case study data neonates first days life used side obsp decoupled influence changes arterial oxygen saturation nirs measurements facilitating use nirs surrogate measure cerebral blood flow cbf second case study used data years old infant extra corporeal membrane oxygenation ecmo side obsp decomposed cerebral peripheral tissue oxygenation sum partial contributions different systemic variables facilitating comparison effects systemic variable cerebral peripheral hemodynamics
hiv aids first addressed security council seen culmination successful securitization process pivotal moment introducing human security however concern epidemic paired problems including nonmilitary issue security council agenda fear peacekeepers vectors hiv reports peacekeepers involved sexual exploitation abuse added problems article aims understand gender informed efforts address issues rehabilitate peacekeeping forces security council legitimacy challenges arose context article argues including nonmilitary issues security council agenda requires adjustment fit war peace logic drawing feminist theories security protection analysis shows security narrative hiv aids form coherent protection logic reformulation hiv aids constructed part problem wartime rape reformulation interpreted appropriation gender equality reproduce military security doctrine
epigenomics one leading frontiers postgenomics medicine challenges prospects ahead epigenomics related merely technology innovation clinical implementation also science communication context micrornas mirnas important part epigenomic regulatory machinery number publications reporting mirna target interactions mtis growing rapidly urgent need standardize reporting study reports analysis published literature databases reporting validated mtis first time best knowledge suggests solution way forward minimum information required mti standard reporting retrieved research reports pubmed web science dating downloaded information diana tarbase mirecords mirtarbase evaluated reporting extracted mti data complemented relevant genomic information suggest standard minimum checklist mti reporting consisting seven pertinent data types mirna gene target gene species experimental validation sequence variants associated phenotype additionally pubmed identification pmid number systematic reviews meta analyses proposal reported shall enable faster development mti databases bioinformatics resources looking future efficient planning experimental designs nascent field epigenomics postgenomics applications
distributed generation system stability grid connected inverters directly related reliable operation grid connected system impedance based analysis method employed effectively study interaction stability grid connected inverters grid means necessary obtain impedance modeling grid connected inverters analysis impedance stability based three phase lcl type grid connected inverter harmonic linearization method adopted paper analyze frequency characteristic phase locked loop pll design approach pll regulator parameters proposed meanwhile impacts factors include pll digital control delay impedance characteristic considered positive sequence negative sequence impedance model gridconnected inverter built combining harmonic linearization symmetrical component methods frequency characteristic pll verified simulation results output impedance model grid connected inverter verified experimental results effectively proved correctness theoretical analysis finally based output impedance model grid connected inverter impedance based analysis method adopted make theoretical analysis experiment validation interaction stability grid connected system
qualitative study investigates experiences using adaptation lego serious play reflective practice pedagogy occupational therapy graduate level students faculty lego serious play innovative facilitated methodology uses brick building metaphoric storytelling form communication problem solving participants engaged four step kinesthetic experience means achieve serious objective results study indicated affirmative participant outcomes included accelerated group cohesion appreciation inclusive learning student voice amplified language emotional content deeper meaning making experiential process using materials appealed various learning styles small number participants experienced minor tension process provoking unanticipated reflective learning results study indicate using kinesthetic brick modeling methodology reflective practice promising higher education pedagogical option
study existence homoclinic solution class nonlinear fourth order ordinary differential equations involve particular cases extended fisher kolmogorov swift hohenberg equations address case source term possesses nonlinear dependence first order derivative solution main result follows iterative method using sequence solutions obtained mountain pass technique order illustrate method numerical examples shown elsevier inc rights reserved
background vitamin modulates inflammation crohn disease programmed death receptor contributes maintenance immune tolerance vitamin might modulate signalling aim investigate expression cell subsets patients treated vitamin placebo methods included patients received vitamin weeks placebo eight healthy controls peripheral blood mononuclear cells pbmcs plasma isolated baseline week expressions surface activation markers analysed flow cytometry soluble plasma levels measured elisa results expression upon cell stimulation increased int cells vitamin treated patients range compared placebo treated patients vitamin treatment placebo decreased expression cell activation marker soluble levels influenced vitamin treatment conclusions vitamin treatment increases int cells ability upregulate response activation reduces expression patients
micro catchment water harvesting systems systems runoff collected contributing area stored adjacent infiltration basin support tree growth dry season increase efficiency systems achieved minimizing non productive water losses mainly occur impounding area period free water available wet soil surface thereafter designing infiltration basin trench potentially meet goal main driver water loss evaporation flux short wave radiation reaches wetted surface first step developing comprehensive model effect objective work reported herein model short wave radiative fluxes different trench geometries model computes radiation reaching floor trench point across trench width accounting direct diffuse reflected components model validation indicated model accurately depicts diurnal course radiation reaching trench floor north south east west orientated trenches summer winter simulations negev desert revealed distinct differences diurnal course mean solar radiation reaching trench floor north south east west orientations rainy season november march radiation load found greater north south orientation thus aiming reduce evaporative losses trench like runoff harvesting systems negev east west orientated trenches advantageous elsevier rights reserved
kernel model part operating system architecture decades upon closer inspection clearly violates principle least required privilege kernel single entity provides many services memory management interfacing drivers context switching ipc real relation ability observe tamper state system work presents antikernel novel operating system architecture consisting hardware software components designed fundamentally secure state art make formal verification easier improve parallelism antikernel system highly modular consists many independent hardware state machines one may general purpose cpu running application systems software connected packet switched network chip noc create verify fpga based prototype system
hippocrates often credited first recognizing food could responsible adverse symptoms even death individuals seminal observations prausnitz investigation food allergy viewed scientific basis first half century periodic reports medical literature describing various food allergic reactions mid late studies charles may colleagues began penetrate medical world skepticism relevance food allergy diagnose since standard skin testing known correlate poorly clinical symptoms may introduction double blind placebo controlled oral food challenge study food allergy became evidence based exponential strides made past four decades study basic immunopathogenic mechanisms natural history diagnosis management food allergies today ige non ige mediated food allergic disorders well characterized efforts treat allergies various immunotherapeutic strategies well way copyright japanese society allergology production hosting elsevier open access article license
aims objectivesthe aim study explore experiences older people self managed following venous leg ulcer healing objectives describe beliefs attitudes actions enablers barriers self management consider impact learning client education package people approach recurrence prevention backgroundvenous leg ulcers affect people worldwide older people ulcers reoccur appreciation experience self management following healing equip health services effectively prepare people self management longer term designa descriptive exploratory design used methodsolder people received learning education programme venous ulcer active interviewed healing july september interviews recorded transcribed thematically analysed resultsparticipants believed efficacy compression therapy skin care activity exercise healthy eating prevent recurrence engage activities reflect recommendations education beliefs conduct self management activities change time regular professional monitoring support would assist people refine health goals plan self management activities prevent recurrence conclusionsparticipation standardised education programme completed prior healing informed successful self management strategies among people seek prevent venous leg ulcer recurrence research consider benefits regular ongoing professional monitoring support among group relevance clinical practiceclinicians role supporting clients know perform believe importance self management strategies healing recurrence prevention clinicians require capacity support clients standardised client education tools facilitate
interval timing crucial decision making motor control impaired many neuropsychiatric disorders previous studies examined timing various strains genetically altered mice parallel male female mice experimental setting investigated timing attention time male female mice presented gaps timed stimulus novel auditory distracters presented interrupted timed stimulus gap distracter combinations sex differences found regard timing accuracy precision however presentation gap distracter combination reset timing males much smaller effect females reset strategy reported previously emotional distracters previously paired footshocic neutral distracters results reveal sex differences attentional gating switching working memory time elsevier rights reserved
paper analyses spatial vision loop city oresund region played important persuasive role legitimizing mobilizing local national political support light rail link along outer ring road greater copenhagen area paper discusses persuasive power spatial concepts supportive storylines bringing transport infrastructure projects onto national policy agenda conclusion paper calls critical attention rationalities underpinning practices persuasive storytelling contemporary strategic spatial planning
background studies report among men severe mental illness smi black caribbean ethnicity display increased risk aggressive behaviour criminal convictions schizophrenia study aimed compare aggressive behaviour criminal convictions among men smi white british black caribbean black african ethnicity explore factors associated differences across ethnicities method sample included male inpatients smi sample included representative sub sample completed interviews authorized access medical criminal files ethnicity self ascribed results staff rated violence prior admission self reported aggressive behaviour convictions non violent violent crimes differed among men smi different ethnicities relative men smi white british ethnicity black african ethnicity showed decreased risk aggressive behaviour black caribbean ethnicity showed elevated risk convictions non violent marginally violent crimes relative men smi black african ethnicity black caribbean ethnicity showed elevated risk aggressive behaviour criminal convictions proportionately men black african black caribbean ethnicity white british ethnicity presented schizophrenia spectrum disorders multivariate analyses failed identify factors would explain differences aggressive behaviour criminal convictions across ethnic groups conclusions differences four different measures aggressive antisocial behaviour among men smi different ethnicities observed factors associated differences found
symbolic computation maple rational solutions lump solutions generalized dimensional shallow water like equation presented using generalized bilinear operator parameter pointed rational solutions classified five classes obtained mainly depending polynomial solutions resulting lump solutions rationally localized directions space acquired making use quadratic function however every nonlinear partial differential equation lump solutions quantity lump solutions fewer rational solutions one class lump solutions generalized dimensional shallow water like equation gotten three plots specific values involved parameters plotted elsevier ltd rights reserved
objective aim study observe effect sex attaining optimal adherence combination antiretroviral therapy cart longitudinally controlling known adherence confounders idu ethnicity design using population based haart observational medical evaluation research cohort data collected hiv positive adults aged least years receiving cart british columbia canada data collected cart adherence assessed using pharmacy refill data proportion participants reaching optimal adherence sex compared per month period initiation therapy onward generalized linear mixed models logistic regression examined effect sex cart adherence results among individuals followed median months interquartile range women indigenous history idu significantly lower proportion women relative men optimally adherent overall covariate analyses adjusted analyses female sex remained independently associated suboptimal adherence overall adjusted odds ratio confidence interval conclusion women living hiv significantly lower cart adherence rates men across year period overall subgroup targeted research required identify barriers adherence among women living hiv tailor women centered hiv care treatment support services
modules operating partially shaded conditions exhibit multiple peaks output power curves cause majority maximum power point tracking mppt techniques become trapped local power peak unfortunately leads additional energy losses could otherwise harvested global maximum power peak gmpp correctly tracked available mppt methods able track gmpp require periodic scanning curve disturbs operation system causes energy losses new mppt technique proposed paper distinguished ability find gmpp without need periodic curve scanning proposed method utilizes mathematical model module well irradiances received cells analytically calculate location gmpp required irradiances innovatively estimated using image module captured optical camera proposed method also combined perturb observe method compensate errors model irradiance estimation experimental verifications conducted validate effectiveness proposed mppt method various shading scenarios
several frameworks incorporate social psychological elements environmentally significant behaviour assume cognitive deliberate decision making household energy consumption behaviours however span spectrum reasoned deliberate unplanned automatic aim paper advance knowledge reasoned unplanned behaviours context pro environmental action using results survey administered occupants urban residential green building study explores five household consumption behaviours tests hypothesis unplanned behaviours poorly predicted reasoned values based behavioural framework using path analyses variables values based framework used predict surveyed behaviours findings indicate behaviours hypothesized unplanned well predicted values based framework framework successfully predicted hypothesized fully reasoned behaviour three potential reasons discussed lack prediction behaviours deeper understanding unplanned automatic habitual behaviours intervene conservation intentions help policy makers building designers better respond influences occupant behaviour building performance
vortex induced vibration viv typical type wind induced vibration long span bridges potential cause large amplitude oscillation low wind speeds span wise correlation vortex induced forces vifs considered prediction vortex induced responses present forced motion tests pressure measurements often used investigate span wise correlation vifs tests may able truly represent nonlinear wind structure interaction viv paper uses newly developed wind tunnel test technique measure vortex induced responses forces different span wise locations study investigates frequency domain characteristics span wise correlation vifs twin box deck smooth turbulent flow fields results show fundamental triple frequency components vifs play major roles viv fundamental frequency component vifs seen perfectly correlated within lock range smooth wind flow even structural damping ratio increases turbulent flow field correlation decays mildly increase turbulence intensity within lock range vif still well correlated even turbulence intensity
ambient intelligence new paradigm information technology creates environments able detect respond users needs actions behaviors feelings user trust plays important role accepting ambient intelligence environments paper describe design implementation virtual reality based test bed studying trust ambient intelligence environments
smart mobile devices including smart phones tablets become one popular devices personal computing environment one major characteristics mobile applications applications field entertainment like games augmented reality require great deal computations order deal smart mobile devices began loaded application processors equipped high performance gpus study feasibility computation intensive mobile applications use gpu resource another gpgpu enabled device space computation tasks verified benefits obtained terms performance energy consumption high performance gpu remote device perform complex computations currently performed local device cpu approach used essential technology distributed computing among mobile devices order verify implemented game reversi using monte carlo tree search mcts algorithm also implemented remote gpu support framework android platform supports task offloading gpgpu enabled remote mobile devices reversi game offloads computationally heavy parts mcts remote gpu remote gpu support framework compared performance energy consumption case mcts completely performed local cpu results showed game winning rate dramatically increases overall energy consumption greatly decreases remote gpu used
emerging evidence indicates dysregulation protein ubiquitination plays crucial role aging associated diseases smad dependent canonical bmp signaling pathway indispensable osteoblastic bone formation could disrupted ubiquitination subsequent proteasomal degradation smad key molecules bmp signaling transduction however whether dysregulation smad ubiquitination disrupted bmp signaling pathway responsible age related bone formation reduction still underexplored pleckstrin homology domain containing family member plekho previously identified ubiquitination related molecule could specifically target linker region domains smurf promote ubiquitination smad found age related increase expression plekho bone specimens either fractured patients aging rodents associated age related reduction smad dependent bmp signaling bone formation genetic approach demonstrated loss plekho osteoblasts could promote smad dependent bmp signaling alleviated age related bone formation reduction addition osteoblast specific smad overexpression beneficial effect bone formation aging could counteracted overexpressing plekho within osteoblasts pharmacological approach showed osteoblast targeted plekho sirna treatment could enhance smad dependent bmp signaling promote bone formation aging rodents taken together suggests increased plekho could suppress smad dependent bmp signaling inhibit bone formation aging indicating translational potential targeting plekho osteoblast novel bone anabolic strategy reversing established osteoporosis aging
study presents efficient algorithm computing precisely hankel singular values linear singularly perturbed systems algorithm obtained terms reduced order problems avoids numerical ill conditioning associated singularly perturbed systems singular perturbation parameter small study compares presented algorithm algorithm exists control engineering literature demonstrates superiority addition analysis system order reduction via balancing singular perturbations performed concluded system order reduction via balancing general system order reduction obtained via method singular perturbations
paper presented electrical circuits rlc using novel fractional derivative regular kernel called caputo fabrizio fractional derivative fractional equations time domain considers derivatives order analysis performed frequency domain conversion time domain performed using numerical inverse laplace transform algorithm furthermore analytical solutions presented circuits considering different source terms introduced fractional equation numerical results different values fractional order gamma exhibits fluctuations fractality time different scales existence heterogeneities electrical components causing irreversible dissipative effects classical behaviors recovered order temporal derivative equal system exhibit markovian nature
influence wind hydrodynamic processes spreading turbid waters vistula lagoon baltic sea studied research based joint analyses remote sensing data concurrent situ measurements three dimensional structure outflow strong difference water optical properties baltic sea vistula lagoon caused intense summer bloom cyanobacteria allowed studies evolution transformation outflow mid july early august using ocean color satellite data situ measurements revealed waters vistula lagoon exclusively present upper water layer study conducted various wind therefore different upwelling downwelling conditions thereby determining different patterns wind driven currents enabled assess impact propagation lagoon outflow one patterns reaching south along vistula spit another one reaching north along sambia peninsula show main spreading direction plume strongly coincides wind driven currents however vortical structures present bay gdansk also affect plume transformation taken account propagation water pollution forecasted
purpose article proposes utility using activity theory analytical lens examine theoretical construct distributed leadership specifically illuminate tensions encountered leaders resolved tensions research method study adopted naturalistic inquiry approach case study elementary school singapore process implementing project using information communications technology instruction leaders identified included principal vice principals middle managers including senior teacher activity theory used lens data analysis findings article makes three contributions distributed leadership first boundary spanning aspects work give rise tensions distribution leadership second tensions provide context exercise influence leadersdemonstrated innovative solutions counter tensions third distribution leadership dynamic centrality leadership shifting multiple levels leaders interact intersecting activity systems case study also confirms importance studying relation structure human agency examining distribution leadership
background research aims evaluate relationship use violent video games vvg emotional desensitization method two hundred one pupils ages years completed questionnaire measuring vvg exposure empathy results correlations regression analyses revealed links exposure vvg vvg experience risk factor presence two moderating variables preexisting empathy amount time spent playing vvg conclusions results suggest exposure risk factor elsevier masson sas rights reserved
eddy currents evident solid core active magnetic bearings ambs omitted commonly used models leading significant error analytical model real system based magnetic circuit method paper presents analytical model including eddy current effects solid core amb current drive voltage drive setting relationship magnetic force effective reluctance half order term induced effective reluctance due eddy currents turning analytical model fractional order effective reluctance appears coefficient term affects system dynamics current voltage drives distinctively half order term changes order model current drive whereas order model changed still kept voltage drive system identification solid core amb verifies proposed models indicates voltage drive effectively reduce eddy current effects compared current drive addition although solid core amb shows fractional order characteristics described well integer order model voltage drive result voltage drive reasonable choice solid core amb since avoids complex fractional order modeling control
objective study determine femoral cartilage thickness fct patients klinefelter syndrome common sex chromosome disorder men varying degrees androgen deficiency cross sectional controlled study conducted tertiary care center participants male patients mean age years aged matched healthy male controls mean age years femoral condyle cartilage measured ultrasonography three locations knee total testosterone estradiol sex hormone binding globulin free androgen index bioavailable testosterone albumin levels measured femoral cartilage patients right left knee lateral mid medial statistically thicker controls right left knee lateral mid medial respectively significant correlation fct sex hormones conclusion patients thicker femoral cartilage relatively low testosterone levels patients altered estrogen metabolism may hypothetically explain increased cartilage thickness patients
patients suffering severe mental illness smi considered especially vulnerable stress study use acute stress services military context affecting civilian populations assessed using naturally occurring data proportion patients previously known smi defined chronic psychotic disorder bipolar disorder among civilians examined center treatment stress military conflict versus usual times compared using chi square statistical test among subjects examined center treatment stress smi diagnosis among subjects examined usual times smi diagnosis patients smi represented statistically significant manner center treatment stress chi although results may imply patients smi vulnerable external stress general population believe may difficulties seeking immediate help traumatogenic contexts order reduce occurrence ptsd gain efficacy treatment primary disorder psychiatric services perhaps make reaching effort identify examine patients community
aimthe aim study assess yield endoscopic evaluation isolated unintentional weight loss uwl patients compared patients weight loss additional symptoms signs patients methodsa retrospective review patients underwent endoscopic evaluation investigation uwl soroka university medical center data clinical indication endoscopic laboratory finding retrieved severe inflammation ulcers achalasia neoplasias considered clinically significant endoscopic findings csef could explain weight loss detection rates csef compared endoscopic studies uwl sole indication group performed uwl least one indication group resultsduring study period patients uwl evaluated endoscopic procedures underwent esophagogastroduodenoscopy egd underwent colonoscopy egd performed patients group mean age men patients group mean age men pathological endoscopic findings identified egds studies detected significant outcomes six group group colonoscopies performed performed group mean age men group patients mean age men abnormal findings found procedures csef found patients two group group conclusionthe diagnostic yield endoscopy investigation patients uwl non negligible considered part baseline evaluation especially older individuals present gastrointestinal manifestations copyright wolters kluwer health inc rights reserved
work demonstrates use smart mobile phone installed android application termed albumin smart test analyzer quantitative determination urinary albumin reaction albumin tetrabromophenolphthalein ethyl ester tbpe presence triton employed detection principle mobile phone exploited sample cassette test paper one sample cassette composes two holders accommodation control test samples test paper designed order contain standard colorimetric strip space situating sample cassette optical images strip samples simultaneously captured single shot digital camera mobile phone digitally processed developed application quantification albumin concentration based self calibration approach advantage self calibration albumin test mobile phone performed ambient light without using extra module integrated lighting control device advantages portability ease implementation rapid analysis min high precision rsd high accuracy recovery mobile device successfully applied diagnosis microalbuminuria elsevier rights reserved
one common distortions images blur makes performing lot image processing computer vision tasks like detection recognition difficult task assessment quality images corrupted blur important active area research nonsubsampled contourlet transform one transformation shift invariant used lot tasks image processing like denoising image enhancement etc paper propose image quality measure blurred images uses non subsampled contourlet transform nsct features support vector regression task image quality assessment images corrupted blur comparative studies well known image sharpness quality measures standard databases correlations human visual system hvs also presented paper
extensive studies reported cognitive abnormalities neurodevelopmental disorders autism spectrum disorder asd another line evidence suggests stress also affects cognitive functions study investigated whether associations stress hormones cognitive functions asd typically developing children cognitive functions asd children evaluated battery psychological tests working memory behavioral flexibility social cognition emotional assessments others asd children exhibited higher hair salivary cortisol reflects chronic acute stress hormone levels subjects respectively children autism spectrum quotient positively correlated hair cortisol scores spence children anxiety scale asd children addition negative correlation present spatial working memory performance hair cortisol asd children results suggest chronic stress hormone elevation may relationships aspects cognitive dysfunction asd subjects author published elsevier ltd behalf ibro
objective describe profile overactive bladder oab patient treatment flexible dose antimuscarinic treatment daily clinical practice methods observational retrospective multicenter study carried public private hospitals adult patients diagnosed oab initiated flexible dose antimuscarinic treatment type antimuscarinic dose concomitant treatments treatment benefit treatment adherence recorded results pluripathological polymedicated population comprised patients mostly women mean age years one year oab evolution main initially prescribed antimuscarinics fesoterodine solifenacine overall patients started treatment low dosage follow visit changed dosage increased dosage decreased dosage patients changed dosage showed significantly greater morbidity worse oab symptoms greater health resources use worse adherence treatment compared maintained high dosage time conclusion differences found regarding demographic clinical characteristics allow identify patients receive different options available dose antimuscarinic drugs although greater benefits seem achieved use highest lowest dose outset change dose
prenatal development highly sensitive maternal drug use due vulnerability disruption fetal brain ongoing neurodevelopment resulting lifelong consequences enhance risk psychiatric disorders cannabis cigarettes commonly used illicit licit substances respectively among pregnant women although behavioral consequences prenatal cannabis cigarette exposure well documented epidemiological clinical studies recently investigations molecular mechanisms associated developmental impact early drug exposure addressed article reviews literature relevant long term gene expression disturbances human fetal brain relation maternal cannabis cigarette use provide translational insights discuss animal models protracted molecular consequences prenatal cannabis cigarette exposure better explored enable future evaluation epigenetic pathways dna methylation histone modification could potentially maintain abnormal gene regulation related behavioral disturbances altogether information may help address current gaps knowledge regarding impact early drug exposure set motion lifelong molecular disturbances underlie vulnerability psychiatric disorders
rssalg software tool experimenting semi supervised learning ssl set machine learning techniques able use labeled unlabeled data training goal reduce human effort regarding data labeling preserving model quality rssalg software encompasses implementation training multi view ssl technique rssalg single view alternative tool enables easy comparison different ssl algorithms provides cross validation procedure supports standard metrics performance evaluation tool free open source available github gnu general public license implemented java language using weka library elsevier rights reserved
conventional phase leading input current plic compensation techniques focused continuous conduction mode ccm boost power factor corrector pfc precedent studies causes plic investigated analyzing current control loop input impedance boost pfc however boundary conduction mode bcm boost pfc current flowing input filter capacitor becomes main cause due large ripple current despite effort compensate current input filter capacitor ifc bcm boost pfc paper new digital control method proposed compensate plic bcm boost pfc minimizing effect ifc proposed method uses derivative input voltage without additional component also proposed method improves displacement factor affect distortion factor resulting high power quality entire input output conditions derivation proposed method presented based time domain analysis effectiveness proposed method experimentally verified rms input output prototype
although bone marrow fibrosis lethal condition underlying mechanism fully understood study aimed investigate pathogenesis fibrosis bone marrow histologic examination mast cell infiltration expression fibrosis associated cytokines analyzed bone marrows fibrosis primary myelofibrosis pmf post essential thrombocythemia myelofibrosis myelodysplastic syndrome mds bone marrow fibrosis bmf immunohistochemical immunofluorescence stainings performed using anti mast cell tryptase interleukin transforming growth factor beta tof beta cdb antibodies number mast cells bone marrows fibrosis significantly higher controls cases fibrosis versus control pmf versus control post myelofibrosis versus control mds bmf versus control moreover bone marrows higher fibrotic grades exhibited greater amounts infiltrating mast cells mast cells positive tgf beta bone marrows fibrosis groups megakaryocytes negative tgf beta post mds bmf megakaryocytes pmf weakly positive tgf beta megakaryocytes negative groups blasts negative tgf beta groups thus tof beta producing mast cells might key players development bmf therefore mast cells could potential therapeutic targets treatment bmf elsevier inc rights reserved
significant proportion solar irradiance reaches earth surface normally attenuated atmospheric properties overcast conditions related rainy season solar analyst model irradiance long term precipitation data used assess relationship guadalajara mexico spatial analysis based morphological statistical criteria increased model certainty model explains irradiation variability observed ground average uncertainties clear sky conditions dry season sunny days wet season meteorological data analysis shows total precipitation atypical temporal distribution slightly lower average deficit precipitation compared long term average found first half season later partially compensated deficit interpreted temporary delay high values precipitation based potential average irradiation model field observations concluded overcast conditions related rainfall attenuated approximately incoming solar energy taking global energy balance account fraction higher comparison energy proportion reflected cloud albedo results suggest high proportion energy attenuated atypical weather conditions may local effects large scale phenomena nino southern oscillation
enormous growth internet usage resulted great amounts digital data handle data sharing become significant unavoidable data owners want data secured perennially available data protection violations thereby become crucial work proposes traitor identification system securely embeds fingerprint provide protection numeric relational databases digital data numeric nature calls preservation usability needs done achieving minimum distortion proposed insertion technique reduced time complexity ensures fingerprint inserted form optimized error leads minimum distortion collusion attack integral part fingerprinting provision mitigate avoiding suggested robustness system several attacks like tuple insertion tuple deletion etc also depicted
one hundred thirty one homeless substance dependent msm enrolled randomized controlled trial assess efficacy contingency management intervention reducing substance use increasing healthy behavior participants randomized conditions either provided additional rewards substance abstinence health promoting prosocial behaviors full study compliance attendance lite purpose secondary analysis determine affect aspd status two primary study outcomes methamphetamine abstinence engagement prosocial health promoting behavior analyses revealed individuals aspd provided methamphetamine negative urine samples participants without aspd controlling participant sociodemographics condition assignment magnitude predicted difference increases reached statistical significance average participants aspd earned fewer vouchers health promoting prosocial behaviors participants without aspd versus participants aspd displayed superior methamphetamine abstinence outcomes regardless schedule even potentially unlimited positive reinforcement individuals aspd displayed suboptimal outcomes achieving health promoting prosocial behaviors elsevier inc rights reserved
due minimal systematic adverse effects transdermal estrogen widely used prevention osteoporosis postmenopausal women present meta analysis aimed clarify effects transdermal estrogen bone mineral density bmd postmenopausal women studies identified searching electronic databases including cochrane library medline embase cinahl databases also sciences citation index systematic review articles published january february reference lists included articles also evaluated consultations made relevant experts studies included desired keywords nine clinical trials met inclusion criteria finally reviewed pooled percent change bmd statistically significant favor transdermal estrogen according resulting pooled estimate lumbar spine bmd one two years transdermal estrogen therapy respectively higher baseline values test heterogeneity statistically significant based heterogeneity index one two years transdermal estrogen delivery effectively increase bmd protect bone structure postmenopausal women
emerging byte addressable non volatile memory technologies phase change memory pcm spin transfer torque ram stt ram offer byte addressability memory durability storage thus making feasible build single level store systems ensure consistency persistent data structures presence power failures system crashes requires flushing cache lines persistent memory frequently thus incurring non trivial synchronization overhead mitigate issue propose two techniques first use non volatile stt ram scratchpad memory chip store recovery information thereby eliminating synchronization cost logging phase due avoidance chip logging operations second present adaptive synchronization policy based caching modes terms data access patterns thereby eliminating unnecessary synchronization cost checkpoint phase evaluation results indicate two techniques improve overall performance compared conventional transactional persistent memory
objectives polycythemia vera related symptoms may adequately controlled conventional therapy current analysis response trial evaluated effects ruxolitinib compared standard therapy quality life qol symptoms patients hydroxyurea resistant intolerant methods previously reported primary analysis ruxolitinib achieved primary composite endpoint hematocrit control reduction spleen volume week current analysis evaluated patient reported outcomes using european organisation research treatment cancer quality life questionnaire core eortc qlq myeloproliferative neoplasm symptom assessment form mpn saf pruritus symptom impact scale psis patient global impression change pgic results compared standard therapy ruxolitinib associated greater improvements global health status qol functional subscales individual symptom scores eortc qlq week patients ruxolitinib arm achieved point improvement global health status qol standard therapy improvements mpn saf symptom scores consistent improvements eortc qlq psis pgic scores conclusions ruxolitinib provides clinically relevant improvements qol ameliorates symptom burden patients hydroxyurea resistant intolerant
study highly instructive novel remote laboratory platform using date software hardware units designed teach main concepts electrical engineering help web based simulations remote accessible experiments real time interactive experimental applications direct current motors several electrical circuits carried study test efficiency system first mathematical model simulation developed matlab models transferred net platform means matlab builder toolbox dynamic library model also created using toolbox libraries embedded interactive web page designed asp net platform data transmission server real experimental set established microprocessor via usb port achieve experimental studies internet real time remote experiments performed data obtained experimental set simultaneously transferred matlab system generates graphical numerical results current experiment results sent user friendly web interface give users feedback experiment wiley periodicals inc comput appl eng educ view article online doi
evolution systems operational life mandatory updates upgrades impair dependability properties dependable systems must evolve accommodate changes new threats undesirable events application updates variations available resources system remains dependable facing changes called resilient paper present innovative approach taking advantage component based software engineering technologies tackling online adaptation fault tolerance mechanisms propose development process relies two key factors designing fault tolerance mechanisms adaptation leveraging reflective component based middleware enabling fine grained control modification software architecture runtime thoroughly describe methodology development adaptive fault tolerance mechanisms evaluate approach terms performance agility elsevier rights reserved
reducing energy consumption mandatory self powered sensor nodes wireless sensor networks obtain energy environment direction one first step optimize network accurately measure total energy harvested determine power available sensor consumption present technique based embedded circuit ultra low power microcontroller accurately measure efficiency flat panel solar thermoelectric generators operating environmental temperature gradients experimental tests showed voltage best case environmental flat panel solar thermoelectric generators applied input converter proposed technique eliminates measurement error compared conventional single supercapacitor strategy
paper proposes method three phase state estimation power distribution network including load tap changers oltc voltage control oltc tap positions essentially discrete variables point view estimation variables presents formidable challenge proposed methodology combines discrete continuous state variables voltage magnitudes angles tap positions hybrid particle swarm optimization hpso applied obtain solution method tested standard ieee bus unbalanced test system models proposed algorithm accurately estimates network bus voltage magnitudes angles discrete tap values hpso based tap estimation provides accurate estimation losses network helps fair allocation cost losses arriving overall cost electricity
paper introduces potential reusing elements context model based development mbuid provides guidance future mbuid systems enhanced reutilization capabilities study based upon development six inter related projects specific mbuid environment supports standard techniques reuse parametrization sub specification inclusion shared repositories analyze experience discuss benefits limitations technique supported mbuid environment system architecture structure composition elements models specification languages decisive impact reusability case elements defined specifications reused resulting reduction specification size inclusion parametrization sub specification facilitated modularity internal reuse specifications development time whereas reuse elements applications greatly benefited sharing repositories elements run time elsevier ltd rights reserved
current article deals preparation characterisation new organoruthenium complexes namely rucp dea sal tsc pph rucp dea sal mtsc pph rucp dea sal tsc pph rucp dea sal ptsc pph new ruthenium complexes characterized various analytical spectral techniques structure ligand dea sal tsc complex rucp dea sal tsc pph confirmed ray crystallography complexes used study toxicity stress resistance aging neuro protective effects taking caenorhabditis elegans model vitro free radical scavenging activity performed dpph free radical scavenging assay complexes exhibited highest scavenging activity standard vitamin lifespan increased mev mutant worms treated complex complex triggered daf nuclear localization increases sod expression reduced amyloid beta protein induced paralysis observed present study confirmed oxidative stress resistance lifespan extension mev mutant showed potential ros scavenging activity complex results also confirmed effective anti aging potential ruthenium complex may developed therapeutic drug prevention aging age related neurodegenerative diseases studies required find exact action complex higher model elsevier rights reserved
previous studies shown self expansion increasing positive self content via engaging novel rewarding activities associated smoking cessation attenuated cigarette cue reactivity study examined whether self expansion associated better adherence weight loss physical activity outcomes within weight loss intervention participants shape rhode island web based community wellness initiative took part randomized controlled trial involved week behavioral weight loss intervention baseline post intervention objective weights self reported self expansion obtained participants treatment adherence assessed objectively self expansion treatment significantly associated percent weight loss including clinically significant weight loss minutes treatment adherence results held controlling relevant covariates first study show self expansion associated better behavioral weight loss outcomes including weight loss adherence results suggest self expansion promising novel target future research could inform health interventions
interface enabling technology advanced product design shown radical development field intelligent sensor embedded system design numerous applications envisaged exploiting interconnectivity particularly field biomedical applications need example growing demand field remote health monitoring control critically ill patients help networked sensors continuous monitoring health patient hospital information fusion multiple sensor data well broadcasting recorded data network ease access clinician implementing decisions clinicians automated drug delivery units could save millions precious lives country limited medical experts follows brief detailed description system developed
paper continues idea previous work knowledge models engineering technology manufacturing knowledge models data models knowledge components explicit implicit tacit surface knowledge presented present paper regarding specific example knowledge model optimum semi finished part choosing straight axes design main stages knowledge model construction presented also solution take shape concept map also analyzed construction knowledge models concept maps treated two levels general one particular proposed example
alzheimer disease cerebrovascular disease aging related cognitive impairment dementia arcid increase prevalence women advancing age development alzheimer disease cerebrovascular disease arcid may postponed prevented protective measures including active treatment vascular risk factors continuing exercise healthy lifestyle early mid life onward bilateral oophorectomy natural menopause associated increased incidence arcid increased risk significantly reduced estrogen therapy recent advances menopause hormone therapy including transdermal estrogen therapy favorably influenced balance benefits risks case made menopause hormone therapy healthy postmenopausal women years starting menopausal transition window opportunity together protective measures delay prevent development arcid later life
graft versus host disease gvhd major complication allogenic bone marrow transplantation involves infiltration donor cells various organs recipient pathological role human cells gvhd remains controversial study established two novel xenogeneic xeno gvhd models human cells purified peripheral blood transplanted immunodeficient nod shi scid ilrg null nog mice human cells induce major gvhd symptoms conventional nog mice however cells immediately proliferated induced severe gvhd transferred nog mice together least cells nog human interleukin transgenic mice human cell transplanted nog mice developed skin inflammations including alopecia epidermal hyperplasia neutrophilia pathogenic helper cells accumulated skin cell transplanted nog mice anti human antibody secukinumab significantly suppressed skin pathologies results indicate pathogenic human cells induce cutaneous gvhd via dependent pathways study provides fundamental insights pathogenesis xeno gvhd humanized mouse models may useful preclinical tools prevention gvhd human cells contribute differently pathogenesis xenogenic graft versus host disease
twin crises depletion fossil fuels environmental degradation motivated researches consolidate use biofuels internal combustion engine applications present study performance emission characteristic calophyllum inophyllum oil based methyl ester diesel blends analyzed various compression ratios comprehensive optimization considering performance parameter along emission characteristic rather involved done carefully designed set experiments analyzed statistically using design expert software higher compression ratio induces high cylinder temperature enhances vaporization thereby better performance certain extent however due high operating temperature oxides nitrogen emission increase also high biofuel blends better combustion phenomenon conditions reduces emissions carbon monoxide unburned hydrocarbon designed empirical statistical model optimum performance lower emission found biofuel tested validated
introduction decisions regarding return play sports related concussion partially revolve around athletes self reported symptoms given emphasis symptoms would beneficial able identify characteristics could predict athletes may susceptible developing increase postconcussion symptoms following head injury purpose study describe symptoms athletes endorse immediately following concussion determine impact injury related characteristics development postconcussion symptoms within first week following concussion method participants included collegiate athletes sustained concussions referred concussion management program postconcussion testing main outcome measures included post concussion symptom scale interview querying athletes retrospective symptoms time starting immediately postinjury results descriptive statistics revealed common immediate symptoms following concussion include dizziness endorsed sample headache feeling fog visual disturbance logistic regression analyses indicated retrograde anterograde amnesia well loss consciousness significantly predictive postconcussion symptoms within one week following concussion however total symptom score assessed immediately postinjury addition endorsing immediate headache symptoms following concussion reliably predicted higher level symptom reporting first week following concussion finally receiver operating characteristic roc curve analysis using sensitivity predict high postconcussion symptom group established cutoff scores immediate total symptom score immediate headache conclusions findings demonstrate importance evaluating symptoms immediately following concussion athletes endorse immediate postconcussion symptoms especially headache symptoms may risk greater severe postconcussion symptoms within first week following concussion present findings implications management treatment sports related concussions
background aims patients familial hypercholesterolemia often characterized premature coronary artery disease cad heterogeneity onset aim present study investigate associations lipoprotein phenotype genotype roles determining cad risk among patients without methods enrolled patients undergoing coronary angiography lipid clinic clinical diagnosed using dutch lipid clinic network criteria mutational analysis ldlr apob pcsk definite probable performed target exome sequencing results levels increased clinical diagnosis unlikely possible definite probable independent patients status hyperlipoproteinemia hlp median without median patients hlp higher prevalence definite probable without multivariate analysis showed phenotype significant determinants predicting early onset severity cad subsequently patients hlp definite probable increased significantly cad risk conclusions levels higher patients phenotype without difference found patients different mutated backgrounds moreover played synergistic role predicting early onset severity cad elsevier rights reserved
objectives immigrants typically healthier native born population receiving country also tend healthier non migrants countries origin foreign born health advantage referred healthy immigrant effect hie examined evidence hie canada design employed systematic search literature immigration health identified eligible studies used narrative method synthesize hie across different stages life course different health outcomes within stage also examined empirical evidence positive selection duration effects two common explanations migrants health advantage deterioration respectively results find hie appears strongest adulthood less childhood adolescence late life foreign born health advantage also robust mortality less morbidity hie also stronger recent immigrants research needed determine critical threshold migrants advantage disappears positive selection explanation hie remains underdeveloped conclusions absence uniform foreign born health advantage across different life course stages health outcomes canada nonetheless remains case hie characterizes majority contemporary migrants since canada foreign born population consists mostly core working age adults
movernaster mitsubishi electric excellent educational robot students learn program automated tasks simulate manufacturing processes publicly introduced utilizes dos based obasic computer code primary interface language robotic drive unit today students however often face great frustration work unfamiliar obasic language even unfamiliar dos operating system address shortcomings mechanical manufacturing engineering department miami university introduced matlab alternative window based interface language better reflect current educational experience students increase functionality robotic arms matlab successfully overcomes limitations obasic dos environment augments capability examples extended capability include use graphical user interfaces facilitate student interaction robotic arm ability move robot along contoured paths matlab instructors develop projects enhance student experience give greater insight robotic applications wiley periodicals inc
recent studies demonstrated benefits osteocalcin ocn glucose homeostasis metabolic dysregulation however role body composition vascular function remains unknown study designed examine changes metabolic parameters body composition well arterial stiffness ocn treatment type diabetic rats adult male sprague dawley rats fed chow high fat diet hfd weeks diabetes induced injection low dose streptozotocin stz treated daily intraperitoneal injections ocn weeks data showed ocn treatment improved glucose homeostasis lipid metabolism analysis revealed ocn treatment resulted increased insulin sensitivity addition untreated diabetic rats experienced significant weight loss whereas ocn treated rats better maintained body weight ocn also changed body composition evidenced reduced body fat mass specifically abdominal fat mass ocn treated diabetic rats also demonstrated decreased pulse wave velocity indicating improved arterial stiffness taken together findings current study revealed ocn therapy prevents arteriosclerosis induced diabetic rat model exerting beneficial effects glucose levels insulin sensitivity lipid metabolites body composition changes
background lymphoma one common pediatric malignancies however well established risk factors therefore investigated maternal perinatal characteristics influenced risk childhood lymphoma procedure information cases diagnosed lymphoma born texas period obtained texas cancer registry birth certificate controls randomly selected ratio controls per case period unconditional logistic regression used generate unadjusted adjusted odds ratios aor confidence intervals following histologic subtypes hodgkin burkitt non non hls non nhls results overall findings indicate specific maternal perinatal characteristics influence childhood lymphoma risk mexico born mothers likely offspring developed compared mothers born united states aor mothers resided time delivery county mexico border likely give birth offspring developed non nhl aor compared mothers living mexico border time infant birth last infants born large forgestational age experienced twofold increase risk aor conclusions population based assessment confirmed previously reported risk predictors childhood lymphoma including sex infant highlighting novel risk factors warrant assessment future studies
background epidemiological studies implicated air pollution causation neurodevelopmental disorders including attention deficit hyperactivity disorder adhd definitive evidence linkage lacking objectives examined association cumulative exposure air pollutants birth diagnosis particularly particulate matter nitric dioxide arid childhood adhd methods used national health insurance service national sample mort population wide health insurance claims dataset total infants age born january december followed year period adhd defined per icd code exposure levels extrapolated using geographic information systems collated subjects administrative district code individual exposure levels assigned hazard ratios hrs calculated development adhd adjusting gender metropolitan area income history diseases results study period adhd occurred subjects increase air pollutants hrs childhood adhd case case compared infants lowest tertile exposure highest tertile exposure fold increased risk adhd conclusion exposure pmio associated incidence adhd childhood elsevier ltd rights reserved
paper presents capacitive sensing system addressing issue collision avoidance partially modelled unknown robot assisted industrial environment means object distance measurement motion tracking surface profile detection sensor consists mesh multiple electrodes digital control module capacitance digital converter data processing module mesh composed metal squares organized form capacitor matrix electrode connections within matrix reconfigured run time digital control logic provide multiple sense functionalities statistical regression models applied derive distance track motion machine learning algorithm support vector machine svm applied measured data classify surface profiles fabricated sensing system ability detecting objects distances sensor shows accuracy profile recognition
woody vegetation global tropical drylands significant importance interannual variability carbon cycle local livelihoods satellite observations past decades provide unique way assess vegetation long term dynamics across biomes worldwide yet actual changes woody vegetation always hidden interannual fluctuations leaf density widely used remote sensing data primarily related photosynthetically active vegetation components quantify temporal trends nonphotosynthetic woody components stems branches global tropical drylands using vegetation optical depth vod retrieved passive microwave observations achieved novel method focusing dry season period minimize influence herbaceous vegetation using moderate resolution imaging spectroradiometer modis normalized difference vegetation index ndvi data remove interannual fluctuations woody leaf component revealed significant trends woody component vodwood areas characterized nonsignificant trend leaf component vodleaf modeled ndvi indicating pronounced gradual growth decline woody vegetation captured traditional assessments method validated using unique record ground measurements semiarid sahel shows strong agreement changes vodwood changes ground observed woody cover reliability obtained woody component trends also supported review relevant literatures eight hot spot regions change proposed approach expected contribute improved assessment example changes dryland carbon pools
let element tau positive divisors tau define paper combining ideas finite fourier transform arithmetic functions ramanujan sums give short proof following result number solutions linear congruence center dot center dot center dot mod kappa vertical bar vertical bar tau sigma vertical bar tau kappa ramanujan sum special cases forms problem already studied several authors problem recently found interesting applications number theory combinatorics computer science cryptography explicit formula generalizes main results several papers example main result paper sander sander number theory one main results paper sander number theory also gives equivalent formula main result paper sun yang int number theory
human cell leukemia virus type also known human lymphotropic virus type htlv retrovirus encodes reverse transcriptase translates viral rna dna provirus integrated host genome virus found causative agent adult cell leukemia lymphoma atl early also found cause neurological disorder tropical spastic paraparesis tsp htlv associated myelopathy ham inflammatory disorder htlv uveitis mid early respectively article reviews eye diseases caused related htlv htlv uveitis ocular systemic complications htlv keratoconjunctivitis sicca interstitial keratitis atl
improvement environment efficiency automotive internal combustion engine becomes fundamental objective cylinder engine surface texture considerably influences functional performances ring pack tribo system surfaces obtained honing process pioneered last decade several innovative honing techniques developed resulting new surface textures different cross hatch angle obtained several stages rough finish honing final stage aim study investigate effect variable cross hatch angle generated final stage measured obtained surfaces measured white light interferometer used input data numerical model estimate friction results show importance residual angle
feedback control mechatronic systems sensor signals usually noisy uncertain measurement errors environmental disturbances uncertainty noise feedback signals may cause instability controlled systems paper presents new model free discrete time sliding mode filter effectively removing noise balancing tradeoff filtering smoothness suppression delay presented filter extension sliding mode filter jin real time quadratic sliding mode filter removing noise adv robot including adaptive gain value determined similar way first order adaptive windowing filter janabi sharifi discrete time adaptive windowing velocity estimation ieee trans control syst technol effectiveness presented filter validated numerical examples experiments
methylphenidate mph stimulant medication commonly prescribed management attention deficit hyperactivity disorder possible adverse effects mph include decreased appetite sleep disturbance weight loss headache abdominal pain anxiety irritability case reports indicated orofacial dyskinesias could develop mph administration report two cases mph induced orofacial dyskinesia asian patients first patient took mph daily one week developed lip smacking lip biting bleeding second patient developed oral buccal dyskinesia immediately took one dose mph purpose case report emphasize importance clinicians paying close attention risk orofacial dyskinesia related mph point treatment even patients receiving standard doses agent
hepatocellular carcinoma hcc fifth common type cancers worldwide however current therapeutic approaches epidemic disease limited year survival rate improved past decades patient derived xenograft pdx tumor models become excellent vivo system understanding disease biology drug discovery order identify new therapeutic targets hcc whole exome sequencing wes performed hcc pdx models among four models exhibited protein altering mutations jak janus kinase gene explore transforming capability mutations introduced hekft cells results demonstrated jak mutation able activate jak stat signal transducer activator transcription signaling pathway drive cell proliferation absence cytokine stimulation vitro furthermore sensitivity treatment jak inhibitor ruxolitinib observed jak mutant pdx model non activating mutant wild type models pharmacodynamic analysis showed phosphorylation stat ruxolitinib treated tumor tissues significantly suppressed collectively results suggested jak activating mutation jak stat signaling pathway vitro vivo jak stat pathway might represent new therapeutic approach hcc treatment monotherapy using potent specific jak inhibitor combinatory therapy explored jak mutant pdx models
mucormycosis rare fungal infection mainly developing compromised hosts associated mortality rate high encountered patient rhinocerebral mucormycosis extended skull amphotericin amph markedly effective saved patient life patient year old male past medical history type diabetes treated dialysis chronic renal failure visited family doctor left cheek pain received treatment diagnosis left sinusitis odontogenic maxillary sinusitis swelling left cheek aggravated dysesthesia left palatine mucosal necrosis developed thus patient transferred department first examination horner syndrome cavernous sinus syndrome observed multiple abscess left bucca mucosal hypertrophy paranasal sinus lesions orbit skull noted treatment severe ondontogenic infection performed mucormycosis diagnosed second histopathological examination necrotized palatal region intravenous administration amph day initiated size reduction lesions confirmed administration weeks lesions completely disappeared thereafter patient died another disease years amph markedly effective saved patient life buccal cellulitis sinusitis develop compromised host necessary take rhinocerebral mucormycosis consideration asian aoms asomp jsop jsoms jsom jami published elsevier ltd rights reserved
ambient intelligence healthcare systems ami hss increasingly deployed hospitals nursing homes medical environment aim supporting physicians manage complexity performing varied medical activities systems able handle multiple medical devices human activities dynamic environment people things evolve time well change position respect operational ambient design reliable ami hss great importance since system considered safety critical software development life cycle sdlc exists supports design reliability approach suited ami must abide international regulations guarantee safety effectiveness fill gap work evidence oriented risk driven design methodology proposed novelty approach consists interleaving risk management activities within sdlc guiding design using evidence produced via probabilistic risk assessment approach
majority adults seeking substance use disorder treatment also smoke smoking associated greater substance use disorder severity poorer treatment outcome increased mortality among substance use disorders yet engaging population smoking cessation treatment significant challenge aim study examine perceived barriers smoking cessation among treatment seeking adults alcohol opioid use disorder additionally examined whether anxiety sensitivity known risk factor barriers smoking cessation general population associated barriers smoking cessation sample sample adults recruited one time study completed self report measures anxiety sensitivity perceived barriers smoking cessation results indicated common barriers anxiety sample tension irritability concerns ability maintain sobriety primary substance abuse reported barriers also reported lower confidence ability change smoking behavior higher anxiety sensitivity associated perceived barriers smoking cessation even controlling cigarette dependence severity results suggest several perceived barriers smoking cessation among treatment seeking adults substance use disorders addition psychoeducational interventions aimed modify negative beliefs smoking cessation anxiety sensitivity may promising therapeutic target population elsevier inc rights reserved
due specific memory effects memristive systems potentially useful building blocks innovative implementations classical techniques nonlinear analog signal processing paper discusses properties memristive systems would amplify usefulness concrete applications turns systems behaving ideal memristors may suitable candidates implementations attention paid simple memristive system threshold switching potentially useful building block various analog applications
epigenetic mechanisms believed link environmental exposures gene expression provide physical basis activation life experiences mental health problems paper provides background hypothesis epigenetic mechanisms link life stresses perinatal childhood adult effects malnutrition eating disorders eds paper reviews literature bearing upon putative link epigenetic factors development examines ways epigenetic alterations could account risk eating disturbances commonly associated behavioral emotional problems ultimately propose epigenetic processes provide intriguing although hypothetical biological platform upon relevant effects perinatal insults life stresses consequences malnutrition may registered argue epigenetically informed understanding may explain eds triggered maintained excessive caloric restraint coincide frequently mood impulse regulation problems tend become increasingly entrenched time finally comment clinical relevance implications epigenetically informed model etiology elsevier inc rights reserved
need high performance computing together increasing trend single processor parallel computer architectures leveraged adoption parallel computing benefit parallel computing power usually parallel algorithms defined mapped executed parallel computing platforms general different alternative mappings defined different performance small computing platforms limited number processing nodes mapping process carried manually however large scale parallel computing platforms hundreds thousands processing nodes applied number possible mapping alternatives increases dramatically mapping process becomes intractable human engineer assist parallel computing engineer provide systematic approach derive feasible mapping alternatives parallel algorithms parallel computing platforms approach includes activities modeling parallel algorithm parallel computing platform generation feasible mapping alternatives generation deployment code finally deployment generated code nodes evaluate approach deriving feasible mapping alternatives four well known parallel algorithms evaluation based simulations real executions generated mapping alternatives copyright john wiley sons ltd
aluminium nitride silicon nitride silicon carbide aln sin sic composite ceramics prepared increase bending strength improve phase structure sin based ceramics ceramics made reactive sintering atmosphere degrees using sintering additive phase composing ceramics identified ray diffractometer microstructure materials studied scanning electron microscopy results indicate phase structure affected remarkably interface modality changed interface sin sic becomes blurry sic aln matches better time liquid phase appears reactive sintering along addition melting point decreased appearance liquid decreases bending strength ceramics lower temperature nitrification technic introduced avoid appearance liquid phase optimum addition investigated xrd sem analysis order obtain maximal bending strength materials
higher education associated healthy lifestyles health literacy remains unclear whether education shapes reactions varying levels genetic risk alzheimer disease study participants national genetic risk survey experiment ngrise received hypothetical genetic risk assessment ranging lifetime risk completed items cognitive perceived threat health emotional general negative affect anticipated behavioral seek information improve health behaviors engage public private civic action reactions risk individuals college education showed reactions increasing genetic risk approximately twice several times strong relative individuals lower high school education fact behavioral reactions significantly increase risk among education educational differences risk response widen older ages elsevier ltd rights reserved
contamination aquatic ecosystems wide range pollutants especially heavy metals cause direct toxic effects become matter general concern throughout last decades aim study determine concentrations heavy metals water sediments fish alburnus alburnus plumbuita lake bucharest romania species fish frequently part local people diet results study provides useful information regarding concentration levels heavy metals water sediments fish plumbuita lake essential assessment environmental quality health living organisms lake ecosystem
present method computing ambient occlusion stack images lambertian scene fixed viewpoint ambient occlusion concept common computer graphics characterizes local visibility point approximates much light reach point different directions without getting blocked geometry received surprisingly little attention vision show approximated using simple per pixel statistics image stacks based simplified image formation model use derived measure compute reflectance illumination objects without relying additional smoothness priors demonstrate state art performance mit intrinsic images benchmark also demonstrate method several synthetic real scenes including printed objects known ground truth geometry
cancer leading cause mortality world osteosarcoma one common types among children years old current treatments including preoperative chemotherapy surgery postoperative chemotherapy produce several side effects limited effectiveness use lipid nanoparticles biodegradable shells controlled drug delivery shows promise effective targeted tumor treatment however vitro validation vehicles limited due fluid stagnation current techniques nanoparticles sediment onto bottom wells killing cells asphyxiation current series experiments results obtained methotrexate lipid nanoparticles dynamic assay conditions presented promising alternative current free drug based therapies effects viability osteosarcoma cell line recirculation cell media free methotrexate blank methotrexate containing lipid nanoparticles concentration successfully assessed addition several designs microfluidic platform used simulated using comsol multiphysics optimized devices fabricated using soft lithography simulated parameters experimentally validated nanoparticles sediment bottom platform demonstrating effectiveness proposed system moreover encapsulated methotrexate effective treatment cell population reduced nearly free methotrexate circulation cell population doubled overall results indicate methotrexate lipid nanoparticles promising targeted therapy osteosarcoma treatment
reinforcement learning appealing approach allowing robots learn new tasks relevant literature reveals plethora methods time makes clear lack implementations dealing real life challenges current expectations raise demand adaptable robots argue employing model based reinforcement learning limited adaptability characteristics robotic systems expanded also model based reinforcement learning exhibits advantages makes applicable real life use cases compared model free methods thus survey model based methods applied robotics covered categorize based derivation optimal policy definition returns function type transition model learned task finally discuss applicability model based reinforcement learning approaches new applications taking consideration state art algorithms hardware
development custom ultrasonic instrumentation motivated need continuous real time monitoring possible leaks mass flow measurement evaporative cooling systems atlas silicon trackers instruments use pairs ultrasonic transducers transmitting sound bursts measuring transit times opposite directions gas flow rate calculated difference transit times sound velocity deduced average gas composition evaluated comparison molar composition sound velocity database based direct dependence sound velocity component molar concentration gas mixture known temperature pressure instrumentation developed several geometries five instruments integrated continuous operation within atlas detector control system dcs finite state machine one instrument monitors coolant leaks pixel detector envelope molar resolution better indicated level cooling loops recently installed pixel detector operational another instrument monitors air ingress condenser new thermosiphon coolant recirculator sub percent precision recent effect introduction small quantity volume total volume thermosiphon system clearly seen instrument custom microcontroller based readout developed instruments allowing readout atlas dcs via modbus tcp ethernet instrumentation many potential applications continuous binary gas composition required including hydrocarbon anaesthetic gas mixtures
ability process manage large data volumes proven enough tackle current challenges presented big data deep insight required understanding interactions among connected systems space time dependent heterogeneous data structures emergence global properties locally interacting data entities clustering phenomena demand suitable approaches methodologies recently developed foundational area data science taking complex systems standpoint deal challenges summarized question complex systems science contribute big data question reversed brought superior level abstraction asking knowledge drawn big data aspects constitute main motivation behind article introduce volume containing collection papers presenting interdisciplinary advances big data area methodologies approaches typical complex systems science nonlinear systems science statistical physics elsevier ltd rights reserved
background jolt accentuation considered sensitive physical finding predict meningitis however studies assessing diagnostic accuracy jolt accentuation therefore aimed evaluate diagnostic accuracy jolt accentuation investigate whether extended patients mild altered mental status methods performed single center retrospective observational study patients presented emergency department japanese tertiary care center january march jolt accentuation evaluated patients fever headache mild altered mental status glasgow coma scale lower defined jolt accentuation broad sense jolt accentuation evaluated patients fever headache altered mental status defined jolt accentuation narrow sense evaluated sensitivity specificity groups results among patients sensitivity specificity jolt accentuation broad sense confidence interval positive likelihood ratio negative likelihood ratio respectively among patients sensitivity specificity jot accentuation narrow sense positive likelihood ratio negative likelihood ratio respectively conclusions jolt accentuation limited value diagnosis meningitis regardless altered mental status therefore meningitis ruled negative jolt accentuation
optimal control problem considered nonliner systems affected sinusoidal disturbances feedforward optimal disturbance rejection control law based output feedback lqr developed analysis optimal disturbances rejection algorithms nonliner systems based time domain state space representation control algorithms based frequency domain output feedback optimal tuning parameters derived achieve purpose optimal disturbances rejection finally simulation results show algorithm high efficiency easy implement well robust respect external sinusoidal disturbances
operating system jitter one causes runtime overhead high performance computing applications many high performance computing applications perform burst accesses accesses consume large amount memory linux kernel runs memory awakens special kernel threads reclaim memory pages kernel threads frequently awakened application performance degraded threads resource consumption well increase application page faults migration cpu cores study empirically analyze impact jitter caused reclaiming memory pages propose method reducing proposed method reclaims memory pages advance kernel thread reclaims pages one time kernel threads thus reducing frequency page reclaim impact jitter conducted experiments using practical weather forecast software results showed proposed method minimized performance degradation caused jitter
accurately reliably tracking undulatory motion deformable fish body great significance scientific researches also practical applications robot design computer graphics however remains challenging task due severe body deformation erratic motion frequent occlusions paper proposes tracking method capable tracking midlines multiple fish based midline evolution head motion pattern modeling long short term memory lstm networks midline head motion state predicted using two lstm networks respectively predicted state associated detections estimate state target moment experiment results show system accurately track midline dynamics multiple zebrafish even mutual occlusions occur frequently
purpose cross sectional observational study investigated whether physical activity levels associated motor performance physical function children treatment acute lymphoblastic leukemia method participants aged years completed treatment months post treatment tested oncology long term follow appointment british columbia children hospital level measured using physical activity questionnaire older children paq motor performance measured using bruininks oseretsky test motor proficiency second edition short form bot physical function measured using minute walk test mwt results thirteen children completed testing paq scores associated bot mwt performance eleven children performed norm mwt children elevated body mass index poorer mwt similar paq scores conclusion found associated motor performance physical function participants overweight obese poorer mwt performance may indicate need closer monitoring post treatment weight status physical function oncology follow setting
violent vibrations reported vertical hangers long span suspension bridge especially located vicinity towers experimental investigation performed characterize wake flow induced vibrations vertical hangers behind tower suspension bridge arranged different stations behind tower column model vertical cables experience violent vibrations frequency detuning phenomenon referred soft lock observed vibration frequencies vertical cables larger natural frequency vibration frequencies vertical cables locked onto upstream vortex shedding within certain velocity range extraneously lock cable vibrations take place based velocity incoming airflow vertical cables subject tower wake flow experience three kinds dynamic responses lower branch buffeting extraneously induced lock vibration upper branch buffeting
increasing demand diverse device applications transparent conducting oxides tcos requires synthesis new tcos type conductivity article materials engineering zno sno ino gao synthesize powders quaternary compound xsn xinxgaxo delta stoichiometry solid state reaction degrees lattice parameters determined ray diffraction xrd technique solubility spinel znsno found degrees solubility limit znsno found optical transmittance approximated vis reflectance spectra showed excellent characteristics optical band gap consistent across slight decrease along increasing value carrier mobility species considerably higher older versions zinc stannate spinel substitutions whereas carrier concentrations moderate
state estimation techniques used improving quality measured signals reconstructing unmeasured quantities chemical reaction systems nonlinear estimators often used improve quality estimated concentrations nonlinear estimators include extended kalman filter receding horizon nonlinear kalman filter moving horizon estimator use state space representation terms concentrations alternative representation chemical reaction systems terms concentrations consists representing systems terms extents paper formulates state estimation problem terms extents allows imposing additional shape constraints sign monotonicity concavity convexity properties extents addition shape constraints often leads significantly improved state estimates simulated example illustrates formulation state estimation problem terms concentrations extents use shape constraints ifac international federation antomatic control hosting elsevier ltd rights reserved
research examined whether individual differences cultural identification discerned zero acquaintance issue examined hong kong idiosyncrasy cultural identification salient social psychological issue participants able perceive accurately targets identification western culture video clip still image findings also indicated stereotype western cultural identity extraversion particular hairstyle facilitated perceptions specifically participants stronger stereotype accurate perceiving western cultural identification targets experimentally manipulated appear extraverted rated strongly identifying western culture participants relatively unfamiliar stereotypes correctly perceive western cultural identification implications findings research multiculturalism also discussed
organic inorganic thin film transistors tfts fabricated simulated tested circuit applications devices based polycrystalline cadmium sulfide cds pentacene thin films devices simulated analyzed using two dimensional finite element simulation methodology cds grain boundary uniform trap distribution approaches implemented assumed traps due grain boundaries uniformly distributed throughout film pentacene poole frenkel mobility model employed matching device simulation experimental data spice model parameters extracted circuit simulation devices tested analog digital circuits operational amplifier opamp inverter circuits tested two opamp topologies compared results discussed one topologies based type transistors using cds tft topology two stage miller compensated cmos design based cds pentacene tfts operational amplifiers open loop voltage gain respectively performance cmos design found limited performance pentacene transistor elsevier rights reserved
high level synthesis hls promises significant shortening fpga design cycle raising abstraction level design entry high level languages however applications using dynamic pointer based data structures dynamic memory allocation remain difficult implement well yet constructs widely used software automated optimizations leverage memory bandwidth fpgas distributing application data separate banks chip memory often ineffective presence dynamic data structures due lack automated analysis pointerbased memory accesses work take step toward closing gap present static analysis pointer manipulating programs automatically splits heap allocated data structures disjoint independent regions analysis leverages recent advances separation logic theoretical framework reasoning heap allocated data successfully applied recent software verification tools algorithm focuses dynamic data structures accessed loops accompanied automated source source transformations enable automatic loop parallelization memory partitioning shelf hls tools demonstrate successful loop parallelization memory partitioning tool flow using three real life applications build traverse update dispose dynamically allocated data structures case studies comparing automatically parallelized direct hls implementations show average latency reduction factor across benchmarks
study examined level crude glycerin total replacement soybean oil partial replacement corn diets tambaqui without ingredient interfering growth performance animals study conducted federal university tocantins evaluating five levels crude glycerin inclusion replicates animals tambaqui animals fed experimental diets period days days adaptation days trial end period animals restrained measure values growth performance animals specific growth rate apparent food conversion feed efficiency hepatosomatic index weight gain condition factor study period deaths indices evaluated animal condition factor presented statistical difference comparing initial final periods experiment inclusion crude glycerin tambaqui diets total replacement soybean oil partial replacement corn used without prejudice growth performance species studied
create possibilities sustainable wastewater management novel system consisting electrodeionization edi solid oxide fuel cells sofcs proposed study system integrated anaerobic digestion landfills capture energy carbonaceous nitrogenous pollutants edi sofcs showed good performances edi removed ammonium nitrogen diluted concentrated synthetic ammonium wastewaters respectively accompanied hydrogen production sofcs converted recovered fuels biogas mixtures methane carbon dioxide electricity optimal conditions edi applied voltage internal electrode distance ied sofcs degrees operating temperature system achieved higher net energy output compared conventional systems estimated energy benefit proposed system showed net energy balance ratio enhanced existing system study local hong kong active landfill facility chemical oxygen demand cod additionally average inorganic ions heavy metals nutrient elements removed raw landfill leachate edi cell results successful demonstrations upgrades anaerobic processes energy extraction wastewater streams elsevier ltd rights reserved
study describes set real time interactive experiments address system identification model reference adaptive control mrac techniques constructing laboratory experiments contribute efficient teaching experimental design instructional strategy crucial process yet defined paper attempt towards filling gap contributions describe sample set experiments senior undergraduate graduate level students strengthen understanding system identification control help instructors wishing set laboratory interactive learning strategy propose set assessment criteria engineering accreditation system identification control laboratories benefit paper engineering educators provides roadmap transferring complex theory problems prototypes laboratory furthermore instructional strategies proposed easily adapted engineering courses
paper proposing generalized specific volume restudy criticality charged ads black holes extended phase space results show previous conclusions generalized without change ratio tildec alpha tilde general case research thermodynamical phase transition black hole leads natural interpretation assumption black hole properties generalized finally study number density charged ads black hole higher dimensions results show necessity assumption
mini batch optimization proven powerful paradigm large scale learning however state art parallel mini batch algorithms assume synchronous operation cyclic update orders worker nodes heterogeneous due different computational capabilities different communication delays synchronous cyclic operations inefficient since leave workers idle waiting slower nodes complete computations paper propose asynchronous mini batch algorithm regularized stochastic optimization problems smooth loss functions eliminates idle waiting allows workers run maximal update rates show suitably choosing step size values algorithm achieves rate order root general convex regularization functions rate strongly convex regularization functions number iterations cases impact asynchrony convergence rate algorithm asymptotically negligible near linear speed number workers expected theoretical results confirmed real implementations distributed computing infrastructure
due higher magnetic flux density larger effective magnetic air gap lesser use ferromagnetic materials large scale direct drive superconducting wind generators high peak fault current torque pose challenge armature windings mechanical supports understanding behavior generators faults important application commercialization paper direct drive wind generator analyzed three phase symmetric short circuit using finite element analyses key differences short circuit behavior generators conventional machines explained effects high fault torque cost weight generator also discussed found higher fault current torque generator mainly caused low reactances nonnegligible armature resistance generator parameters including use ferromagnetic materials value magnetic loading pole number number turns per armature coil number armature winding sets significant influence reactances fault current torque influences parameters fault current torque three phase symmetric short circuit analyzed detail moreover several ways decrease fault current torque terms machine design proposed
despite recent success newly developed direct acting antivirals hepatitis disease continues global health threat due lack diagnosis carriers high cost treatment heterodimer formed glycoproteins within hepatitis virus hcv lipid envelope potential vaccine candidate antiviral target structure yet resolved partial crystal structures ectodomains determined unresolved parts structure within realm modeled current computational modeling tools furthermore variety additional experimental data available support computational predictions structure data antibody binding studies cryo electron microscopy cryo mutational analyses peptide binding analysis linker scanning mutagenesis nuclear magnetic resonance nmr studies accordance rich experimental data built silico model full length heterodimer model supports assembles trimer previously suggested study falson coworkers falson bartosch alsaleh tews loquet ciczora riva montigny montpellier duverlie pecheur maire cosset dubuisson penin virol https doi org jvi size exclusion chromatography western blotting data obtained using purified recombinant support hypothesis model suggests virus assembly trimer may assembled pentamer pentamers comprising single hcv virion anticipate new model provide useful framework hcv envelope structure development antiviral strategies importance one hundred fifty million people estimated infected hepatitis virus many risk infection better understanding structure hcv envelope responsible attachment fusion could aid development vaccine new treatments disease draw upon computational techniques predict full length model heterodimer based partial crystal structures envelope glycoproteins widely studied experimentally provides valuable data assisted modeling proposed structure used suggest organization hcv envelope also present new experimental data size exclusion chromatography support computational prediction trimeric oligomeric state
objectivestrategies optimize development sunscreens include use theoretical sunscreen simulators predict sun protection factor spf uva protection factor uva vitro measurements uva aims study assess correlations spf uva results obtained theoretical sunscreen simulator observed vivo spf uva vitro uva results uva observed vitro vivo products different galenic forms containing pigments methodsbasf sunscreen simulator software used evaluate theoretical performance formulations regarding spf uva protection vitrouva vivospf determined formulations uva pfin vivo measurements carried products galenic forms compact foundations lip balms presence dye pigments could make results uva pfin vitro less reliable due possible uneven film formation resultsthe results spf calculated basf sunscreen simulator presented good correlation spf observed vivo absence pigments good correlation presence pigments uva calculated basf sunscreen simulator also exhibited good correlation uva measured vitro formulations containing pigment good correlation formulations containing pigment correlation uva calculated basf sunscreen simulator uva measured vivo formulations containing pigment considered good addition measurements uva pfin vivo presented good correlation values obtained vitro conclusionin present study use basf sunscreen simulator vitrouva tests showed good correlations vivo results could considered valuable resources development sunscreens resume objectifles strategies pour optimiser developpement des ecrans solaires comprennent utilisation simulateurs protection solaire theoriques pour predire facteur protection solaire spf uva uva des mesures vitro uva les buts presente etude etaient evaluer les correlations entre spf les resultats uva obtenus dans simulateur solaire theorique avec ceux observes vivo spf uva vitro uva les resultats uva observes vitro vivo pour les produits sous differentes formes galeniques contenant non des pigments methodesle logiciel basf sunscreen simulator ete utilise pour evaluer performance theorique des formulations concernant spf protection contre les uva vitro uva vivo spf ont ete determines pour toutes les formulations les mesures uva vivo ont ete realisees uniquement sur les produits pour lesquels les formes galeniques fondations compactes baumes pour les levres presence colorants des pigments peuvent rendre les resultats des uva vitro moins fiables raison une possible formation film inegal resultatsles resultats spf calcules par basf sunscreen simulator presentent une tres bonne correlation avec fps observee vivo absence pigments une bonne correlation presence pigments uva calcule par basf sunscreen simulator presentait egalement une tres bonne correlation avec les uva mesuree vitro pour les formulations contenant pas pigment une bonne correlation pour les formulations contenant des pigments correlation meme uva calcule par basf sunscreen simulator avec uva mesure vivo pour les formulations contenant pigment etait qui est considere comme bon outre les mesures uva vivo ont presente une bonne correlation avec les valeurs obtenues vitro conclusiondans presente etude utilisation basf sunscreen simulator des tests uva vitro ont montre bonnes correlations avec les resultats vivo pourraient etre consideres comme des ressources precieuses dans developpement des ecrans solaires
early century witnessed boom green building san francisco similar cities major downtown property owners investors retrofitted office towers commissioned green certification critically explored greening might pay greening initiatives transcend corporate social responsibility represent new attempt enclose speculate upon green value within second nature cities however unconventional resource discovery requires highly partial view buildings socio natural entanglements beyond city illuminate efforts obscurities exploring experience exemplary green building san francisco office tower successively served headquarters organizing vast resource periphery american west symbol driver transformation city second nature financial resource right recently asset emerging global market green property
background amphibians declining alarming rate one major causes decline infectious disease chytridiomycosis parasitic fungal sporangia occur within epidermal cells causing epidermal disruption changes well characterised apoptosis planned cell death damaging response host may alternatively mechanism pathogen removal intracellular infections methods study experimentally infected two endangered amphibian species pseudophryne corroboree litoria verreauxii alpina causal agent chytridiomycosis quantified cell death epidermis two assays terminal transferase mediated dutp nick end labelling tunel caspase results cell death positively associated infection load morbidity clinically infected animals infected amphibians tunel positive cells concentrated epidermal layers correlating localisation infection within skin caspase activity stable low early infection pathogen loads light increasing animals recovered infection caspase activity gradually returned normal infection cleared whereas amphibians recover caspase activity increased dramatically infection loads peaked discussion increased cell death may pathology fungal parasite likely contributing loss skin homeostatic functions also possible apoptosis suppression may used initially pathogen help establish infection research explore specific mechanisms cell death specifically apoptosis regulation fungal infection
background quantifying gene expression single cell level fundamental complete characterization synthetic gene circuits due significant impact noise inter cellular variability system functionality commercial set ups allow acquisition fluorescent signal single cell level flow cytometers quantitative microscopes expensive apparatuses hardly affordable small laboratories methods protocol makes standard optical microscope able acquire quantitative single cell fluorescent data bacterial population transformed synthetic gene circuitry presented single cell fluorescence values acquired microscope set processed custom made software compared results obtained flow cytometer bacterial population transformed gene circuitry results high correlation data two experimental set ups correlation coefficient computed tested dynamic range proves standard optical microscope coupled appropriate software image processing might used quantitative single cell fluorescence measurements calibration set together validation described conclusions experimental protocol described paper makes quantitative measurement single cell fluorescence accessible laboratories equipped standard optical microscope set ups method allows affordable measurement quantification intercellular variability whose better understanding phenomenon improve comprehension cellular behaviors design synthetic gene circuits required software freely available synthetic biology community musiq microscope fluorescence single cell quantification
pseudotumor cerebri syndrome ptcs also known idiopathic intracranial hypertension iih characterized signs symptoms increased intracranial pressure headache cranial nerve palsies absence space occupying mass condition commonly affects overweight women childbearing age even also frequent men children children ptcs may present atypical signs symptoms different prognosis compared adults however treatment children adults even strict treatment guidelines regards treatment strategies children based retrospective studies none evaluated prospective randomized controlled trial studies review focuses literature data ptcs treatment children
investigate fluid mechanics removing passive tracer contained small thin viscous drops attached flat inclined substrate using thin gravity driven film flows focus case drop detached either partially completely surface mechanical forces exerted cleaning fluid drop surface instead convective mass transfer establishes across drop film interface dilute passive tracer dispersed drop diffuses film flow transports away peclet number passive tracer film phase high whereas peclet number drop phase varies approximate characteristic transport time drop much larger film model mass transfer passive tracer bulk drop phase film phase using empirical model based analogy newton law cooling simple empirical model supported theoretical model solving quasi steady two dimensional advection diffusion equation film coupled time dependent one dimensional diffusion equation drop find excellent agreement experimental data two models predict exponential decrease time tracer concentration drop results valid drop film peclet numbers studied overall transport characteristic time related drop diffusion time scale diffusion within drop limiting process result remains valid even approximate finally theoretical model predicts well known relationship sherwood number reynolds number case well mixed drop proportional gamma based drop length film shear rate gamma film kinematic viscosity show relationship mathematically equivalent physically intuitive relationship proportional delta based diffusive boundary layer thickness delta model also predicts correction case non uniform drop concentration correction depends delta film schmidt number drop aspect ratio diffusivity ratio two phases prediction remarkable agreement experimental data low drop peclet number continues agree approaches although influence reynolds number increases proportional delta
paper low voltage low dropout ldo regulator designed simulated cmos technology converts input voltage stable regulated output voltage using spice circuit simulator two stage operational amplifier amp used error amplifier artificial bee colony abc evolutionary algorithm based optimizer demonstrated solving problem device sizing parameters amp optimization approach designing two stage amp circuit require analytical calculations handles non linear effects sub micron devices effectively designed ldo tested change load current found power supply rejection ratio psrr found khz mhz settling time less sec observed testing line load regulations
background use chemotherapy near end life patients metastatic cancer often ineffective toxic data factors associated use remain scarce especially europe methods nationwide register based study including hospitalized patients aged years died metastatic solid tumors france results total hospitalized patients died metastatic cancer included last month death received chemotherapy including last weeks female sex older age year increase higher number chronic comorbidities independently associated lower rates chemotherapy although patients chemosensitive tumors statistically likely receive chemotherapy last month death association mostly fueled testis ovary tumors found obvious pattern expected chemosensitivity different cancers rates chemotherapy use close death compared university hospitals patients died profit clinics hospital comprehensive cancer centers likely receive chemotherapy finally high volume centers hospitals without palliative care units reported greater average rates chemotherapy near end life conclusion among hospitalized patients cancer young individuals treated comprehensive cancer centers high volume centers without palliative care units likely receive chemotherapy near end life found evident pattern expected chemosensitivity different cancers probability patients receive chemotherapy close death
graphic clipping algorithm hotspot time computer graphics based upon non intersect polygon boundary clipping algorithm vector graphics proposed paper proposed algorithm divided three steps first eliminating boundary intersection vector graphics calculating effective intersections second dividing graphics several parts finally determining whether part within boundaries achieving graphic clipping besides demonstrated experiments compared traditional algorithm proposed algorithm clear simple effective applied widely furthermore proposed algorithm consumes seconds millions data memory consumption nearly unchanged
network intrusion attempts rise recently researchers shown increased interest assessing security situation entire network instead single asset considerable amount assessment models designed however lack solid standard guidelines define importance network asset addition based knowledge research found adequately covered cost factor assessment model thus purpose paper propose cost sensitive entropy based network security situation assessment model aid analytic hierarchy process ahp model quantitatively determine importance assets network considering tangible intangible criteria verify performance proposed model simulation national advanced ipv centre nav network environment setup simulation results regarding security situation particular time interval promising hence proposed model able provide network administrator reliable reference decision making organization network
prove element coercive discrete efk equation possesses infinity solutions changes sign least twice corollary prove solves parallel parallel infinity infinity provided unique local minimum minimum nondegenerate int finally give criteria ensuring existence non existence periodic solutions multiple wells elsevier inc rights reserved
comparison aeroelastic response four aeroelastic models representing three different construction stages completion stage izmit bay suspension bridge turkey presented wind tunnel tests performed laboratory smooth turbulent flow conditions investigate aeroelastic stability buffeting response completion bridge results used reference considerations variation structural characteristics different aerodynamics various construction stages influence bridge stability buffeting response elsevier ltd rights reserved
kind novel electromagnetic structure cassini cross section proposed simulation implemented business microwave soft cst based finite integral technique fit electromagnetic field mode type cassini wave guide belongs electromagnetic field intensity stronger near neck region areas cassini electromagnetic patches lumped elements radar cross section rcs smaller around chz dbsm absorbing property better around ghz dbsm difference rcs comparing pure medium novel radiation structure cassini cross section patches electromagnetic field value larger neck areas two half patches last potential application development cassini oval structure put forward electromagnetic stealth technology antennae design
understanding dynamics mental health recently resettled refugees essential component comprehensive resettlement program yet establishing components successful acceptable mental health intervention elusive task semi structured interviews conducted resettled refugees five countries received treatment depression post traumatic stress symptoms anxiety themes generated interviews emphasized need strong group based social support well focus practical needs acquiring maintaining employment language literacy training access care
temperature field variation law distribution characteristics orthotropic flat steel box girder sunny conditions analyzed field temperature test steel box girder operational runyang yangtze river bridge suspension bridge part function optimization fitting error analysis test data conducted temperature gradient distribution curve applicable hexagonal flat steel box girder proposed based measurement results temperature effect orthotropic flat steel box girder analyzed using finite element method effects different temperature gradient modes mechanical characteristics stress distribution steel box girder compared sunny conditions heat conduction flat steel box girder structure shows distinct box room effect characteristics actual temperature gradient distribution inconsistent one suggested existing standards thermal stress steel box girder calculated measured temperature gradient mode exceeds calculated standard intensity approximates action designed vehicle loads temperature induced stress distributed centrally near manufacturing welds orthotropic steel box girder considered design construction research results study could supplement existing bridge culvert design standards
magnetorheological fluid fluid kind smart material used new pressure carrying medium magnetorheological pressure forming mrpf mechanical property fluid pressure significantly affects sheet formability however little knowledge deformation behavior fluid three dimensional stress states paper new procedure via combination extrusion test fem simulation proposed determine flow stress fluids experimental device extrusion test fluids designed flow stresses fluid mrf four different magnetic fields determined proposed procedure addition obtained flow stresses used following fem simulations verify accuracy comparing experimental results simulation results good agreement experimental data supports correctness practicability proposed method elsevier rights reserved
safer family block ciphers comprised safer safer safer safer safer proposed strengthen key schedule safer safer designed aes candidate safer among cryptographic primitives selected second phase nessie project paper presented first zero correlation linear cryptanalytic attack safer block cipher family investigated linear properties pht employed linear layer safer block ciphers identified zero correlation linear approximations safer safer safer moreover displayed several characterizations undisturbed bits found exists undisturbed bit exponential box applied reduce computational complexity key recovery attacks rounds safer rounds safer rounds safer rounds safer block ciphers attacked linear relations correlation zero
feature selection problem data mining addressed proposing objective genetic algorithm based feature selection method boundary region analysis rough set theory multivariate mutual information information theory used two objective functions proposed work select precise informative data data set data set sampled replacement strategy method applied determine non dominated feature subsets sampled data set finally ensemble objective genetic algorithm based feature selectors developed help parallel implementations produce much generalized feature subset fact individual feature selector outputs aggregated using novel dominance based principle produce final feature subset proposed work validated using repository especially feature selection datasets well uci machine learning repository datasets experimental results compared related state art feature selection methods show effectiveness proposed ensemble feature selection method elsevier rights reserved
objective investigate prevalence location severity pain well association psychosocial clinical variables impact functional impairment fatigued patients type diabetes methods severely fatigued patients type diabetes completed questionnaires pain mcgill pain questionnaire mpq short form health survey subscale bodily pain fatigue severity checklist individual strength subscale fatigue severity cis depressive symptoms beck depression inventory primary care bdi functional impairment sickness impact profile sip hbac diabetes related complications assessed physical activity measured using actigraphy results patients reported pain muscle joint back pain headache common patients pain often female reported complications mean number scored higher bdi measuring depressive symptoms mean score compared patients without pain pain associated diabetes duration number complications fatigue severity depressive symptoms functional impairment hbac physical activity patients pain reported high impact pain pain beta fatigue severity beta contributed functional impairment conclusion pain highly prevalent fatigued patients type diabetes although pain impact severity relatively low location pain symptoms similar location general population pain related fatigue contributes independently functional impairment fatigue interventions address pain elsevier inc rights reserved
cloud computing technology becoming mature essential combine big data processing tool hadoop infrastructure service iaas cloud platform study first propose new dynamic hadoop cluster iaas dhci architecture includes four key modules monitoring scheduling virtual machine management migration modules load physical hosts vms collected monitoring module used design resource scheduling data locality solutions second present simple load feedback based resource scheduling scheme resource allocation avoided overburdened physical hosts strong scalability virtual cluster achieved fluctuating number vms improve flexibility adopt separated deployment computation storage vms dhci architecture negatively impacts data locality third reuse method migration propose dynamic migration based data locality scheme using parallel computing entropy migrate computation nodes different host rack corresponding storage nodes deployed satisfy requirement data locality evaluate solutions realistic scenario based openstack substantial experimental results demonstrate effectiveness solutions contribute balance workload performance improvement even heavy loaded cloud system conditions
human kallikrein klk highly expressed central nervous system elevated level demyelinating disease klk restricted specificity arginine hydrolyses myelin basic protein protein activator receptors human ionotropic glutamate receptor subunits report previously unreported activity klk peptides containing clusters basic amino acids synthetic fluorogenic peptidyl arg amino carbamoylmethylcoumarin peptidyl acc peptides fret peptides format abz peptidyl eddnp abz ortho aminobenzoic acid eddnp glutaminyl dinitrophenyl ethylenediamine pairs sequences basic amino acids introduced surprisingly klk hydrolyzed fluorogenic peptides arrow acc arrow mca two groups resulting non fluorescent products fret peptides containing furin processing sequences human mmp nerve growth factor ngf neurotrophin neurotrophin cleaved klk position expected furin finally klk cleaved fret peptides derived human proenkephalin frequent basic residues flanking enkephalins human proenkephalin sequence result suggests ability klk release enkephalin proenkephalin precursors resembles furin canonical processing proteolytic enzyme molecular models peptides built klk structure marked preference cut two examined peptides related extended conformation substrates elsevier rights reserved
objectives beyond male female binaries gender roles represent masculine feminine traits assimilate enact throughout life span development bem proposed androgynous individuals adeptly adapt different contexts alternating strong repertoire masculine feminine gender roles contrast undifferentiated individuals may adapt well social norms weak self endorsed masculinity femininity methods among adults mean standard error age years women working psychiatric hospital hypothesized androgynous individuals would present better mental health less physiological dysregulations known allostatic load undifferentiated individuals indexed using biomarkers using conventional inclusive formulation ascribes cutoffs without regard sex alternative sex specific formulation cutoffs tailored sex separately controlling sex hormones testosterone estradiol progesterone well validated questionnaires used results independent sex androgynous individuals experienced higher self esteem well lower depressive symptoms undifferentiated individuals men manifested higher women using inclusive index contrast sex specific algorithm unmasked sex gender roles interaction highest levels undifferentiated men analysis using gender index based seven gendered constructs revealed greater propensity toward feminine characteristics correlated elevated sex specific conclusions beyond providing psychobiological evidence bem theory study highlights sex specific formulations detect effects sociocultural gender
simple novel predictive duty cycle control strategy boost pfc converter proposed duty cycle calculated based input current input voltage output voltage every cycle operating principles control scheme analyzed discussed detail experimental results boost power pfc prototype point high power factor low input current thd achieved entire output power range using proposed control strategy results prove satisfactory
radio communications possessing high signal quality long distance propagation traditionally difficult achieve reliably shortwave bands mhz due analog modulation schemes use vulnerability shortwave radio atmospheric disturbances development digital radio mondiale drm standard provided digital coding methods audio compression data protection features shortwave transmissions drm nonprofit humanitarian broadcasters underdeveloped nations reliable high quality long distance transmission technology lower cost satellite radio services development versatile drm receivers therefore necessary paper presents design drm receiver capable demodulating single drm transmission channel compares receiver performance commercial drb receiver plans future improvement receiver overall signal noise ratio resilience signal fading discussed including addition multi channel reception capability maximum ratio combining mrc diversity algorithm
work deals optimizing methodology fabrication monodisperse metallic nanoparticles active microbes using micellar core amine based metallosurfactant novel double chained amine metallosurfactants type chnh copper nickel cobalt synthesized characterized elemental analysis fourier transform infrared spectroscopy ftir nuclear magnetic resonance nmr thermogravimetric analysis tga study theaggregated structures bilayer lipophilic metallosurfactants various alcohols carried thermodynamics parameters reverse micellization also estimated process micellization spontaneous entropy driven prepared metallosurfactants utilized precursors fabrication metallic nanoparticles nps method validated three studied transition metals preparation metallic nanoparticles approach offers better results terms size shape morphology distribution stability nps characterization nps done vis ray diffraction xrd transmission emission microscopy tem dynamic light scattering dls prepared metallosurfactants nps trialled antimicrobial activity three pathogenic microbes viz bacillus cereus gram bacterium klebsiella pneumoniae gram bacterium curvularia lunata fungus best results shown nps furthermore interaction metallic nps bovine serum albumin bsa estimated published elsevier
objectives identify effective aerobic exercise programs provide clinicians patients updated high quality recommendations concerning traditional land based exercises knee osteoarthritis methods systematic search adapted selection criteria included comparative controlled trials strengthening exercise programs patients knee osteoarthritis panel experts reached consensus recommendations using delphi survey hierarchical alphabetical grading system used based statistical significance clinical importance improvement results five high quality studies included demonstrated various aerobic training exercises generally effective improving knee osteoarthritis within week period aerobic exercise program demonstrated significant improvement pain relief grade physical function grade quality life grade aerobic exercise combination strengthening exercises showed significant improvement pain relief grade physical function grade grade conclusion short term aerobic exercise program without muscle strengthening exercises promising reducing pain improving physical function quality life individuals knee osteoarthritis
invasive computing paradigm offers applications possibility dynamically spread computation multicore multiprocessor system resource aware way applications assumed act maliciously many security problems arise acticle discuss different ways deal security problems resource aware way first formalize attacker model different security requirements applications may multi core systems survey different hardware software security mechanisms dynamically configured guarantee security demand invasive applications
background dearth health personnel low income countries attracted global attention ways health care services delivered efficient effective way using available health personnel explored task sharing expands responsibilities low cadre health workers allows share responsibilities highly qualified health care providers effort best utilize available human resources appropriate country like nigeria shortage qualified health professionals huge burden maternal mortality resulting obstetric complications like pre eclampsia study examines prospect task sharing among community health extension workers chew detection early signs pre eclampsia ogun state nigeria methods study part larger community based trial evaluating acceptability community treatment severe pre eclampsia ogun state nigeria data collected using focus group discussions seven chews three male decision makers six community leaders one member society obstetricians gynaecologists nigeria addition interviews conducted heads local government administration directors planning medical officers chief nursing officers qualitative data analysed using nvivo version computer software results non availability health personnel major challenge resulted high proportion facility based care performed chews result chews often take roles designated senior health workers role expansion exposed chews basics obstetric care resulted informal task sharing among health workers knowledge ability chews perform basic clinical assessments measure blood pressure doubt nevertheless divergent views senior junior cadres health practitioners chews abilities providing obstetric care similarly concerns various stakeholders particularly chews regulatory restrictions placed standing order conclusion generally extent obstetric tasks could shifted community health workers determined training provided extent observed barriers addressed
background neonates expected weight loss first days life many factors considered affect newborn weight loss breastfeeding adequacy maternal parity intravenous fluids administered labor environmental factors studies yielded variable results primary objective study assess pattern newborn weight loss initial birth factors affecting secondary objective assess impact initial weight loss neonatal jaundice beyond regaining birth weight day life materials methods study carried term exclusively breastfed newborn babies neonates weighed initially birth regularly hourly intervals data pertaining various maternal factors affecting neonatal weight loss birth weight newborns adequacy breastfeeding recorded weight neonates day also recorded results babies lost birth weight babies lost maximum weight loss occurred life mean standard deviation percentage weight loss babies inadequate breastfeeding compared adequately breastfed babies mean percentage weight loss babies born primipara multipara neonates developed significant jaundice mean percentage weight loss compared rest subgroup babies lost birth weight regain birth weight day life compared babies subgroup weight loss conclusion regular monitoring weight exclusively breastfed babies potentially useful particular attention may need given primipara mothers babies lose weight
chemosensation mammalian nose comprises detection odorants irritants pheromones traditional view assigned one distinct sub system stimulus type recent research produced complex picture odorants detected olfactory sensory neurons also trigeminal system irritants turn may distinct odor pheromones detected olfactory epithelium moreover well established irritants change odor perception vice versa wealth psychophysical evidence olfactory trigeminal interactions humans contrasts paucity structural insight particular unclear whether two systems communicate sharing stimuli whether neuronal connections mediate cross modal signaling one connection could exist olfactory bulb performs primary processing olfactory signals receives trigeminal innervation present study neuroanatomical tracing mouse ethmoid nerve illustrates peptidergic fibers enter glomerular layer olfactory bulb local microcircuits process filter afferent signal biochemical assays reveal release calcitonin gene related peptide olfactory bulb slices attenuation camp signaling neuropeptide non stimulated tissue neuropeptide specifically inhibited basal activity calbindin expressing periglomerular interneurons affect basal activity neurons expressing calretinin parvalbumin tyrosine hydroxylase activity astrocytes study represents first step toward understanding trigeminal neuromodulation olfactorybulb microcircuits provides working hypothesis trigeminal inhibition olfactory signal processing
one important problems home automation dedicated reducing energy consumption different methods proposed mostly aiming low costs approaches paper offers low cost solution based stmf microcontroller solution implemented house situated four season geographical area obtained results extremely promising indicating reducing energy consumption approximately
purpose construction projects usually suffer delays causes delays cost overruns widely discussed weather one recurrent purpose paper analyze influence climate standard construction work activities case study design methodology approach studying extent weather variables impede outdoor work effectively executed new maps tables planning delays presented addition real case regarding construction several bridges southern chile analyzed findings studies thoroughly addressed influences major climatic agents common outdoor construction activities method detailed provides first approximation construction planners assess extent construction productivity influenced climate research limitations implications although study performed chile simplified method proposed entirely transferable country however weather combinations weather variables could needed environments countries practical implications implications help reducing negative social economic environmental outcomes usually emerge project delays originality value climatic data processed using extremely simple calculations create series quantitative maps tables would useful construction planner decide best moment year start project possible build
paper based variable coefficient nonlinear schrodinger vcnls equation amplification fundamental second order unchirped solitons dispersion decreasing fiber without external amplification device different existing literatures studied via symbolic computation soliton solutions vcnls equation obtained fundamental soliton pulse amplitude amplified gain propagation whereas width keeps unchanged equilibrium gain nonlinearity varying dispersion soliton structure destroyed amplified fundamental soliton free pedestal chirp increase absolute value gain coefficient magnification fundamental soliton amplitude enhanced propagation distance second order soliton width compressed amplitude amplified amplification process accompanied compression soliton period second order soliton decreases exponentially propagation decreases increase absolute value propagation distance
paper optimization problem introduced computer tool kits used solve optimization problems outlined respective strength weakness state art optimization programming language ibm ilog opl presented high level opl facilitates modeling solving optimal problem application fields significantly ibm ilog opl model shortest path problem implemented ibm ilog opl model shortest path problem building block algorithm center graph illustrated calling building block different data consecutive way algorithm implemented ibm ilog script language approach enable engineers kinds field solve optimal problems since underlying mechanism optimization need grasped
porphyrins interest many applications involve electron transfer absorption light solar energy photodynamic cancer therapy newly synthesized tetrakis dibenzyloxyphenyl porphyrin tdbopp characterized using nmr nmr vis fluorescence spectroscopy maldi tof tof high resolution mass spectrometry standard nmr nmr experiments coupled nuclear overhauser effect noe experiments confirmed structure compound expected ions observed maldi tof tof mass spectrum vis absorption spectrum tdbopp shows soret band three bands molar absorptivity respectively excitation gives emission quantum yield porphyrin
present pilot study sought identify predictors delays child sexual abuse csa disclosure specifically whether emotional physical abuse parental figure contributes predicting delays important victim factors alleged csa victims whose parental figures purported sexual abuse perpetrators interviewed case files reviewed across two waves longitudinal study regression analyses indicated experiencing emotional physical abuse parental figure uniquely predictive longer delays disclosure csa perpetrated someone parental figure victim csa perpetrator relationship type sexual abuse duration also significantly predicted csa disclosure delay whereas victim age time police report victim gender victims feelings complicity significant unique predictors child abuse victims expectations lack parental support may underlie findings parent child relationships likely crucial timely disclosure csa even parent csa perpetrator elsevier ltd rights reserved
background grapevine flower number per inflorescence provides valuable information used assessing yield considerable research conducted developing technological tool based image analysis predictive modelling however behaviour variety independent predictive models yield prediction capabilities wide set varieties never evaluated results inflorescence images grapevine vitis vinifera varieties acquired field conditions flower number per inflorescence flower number visible images calculated manually automatically using image analysis algorithm datasets used calibrate evaluate behaviour two linear single variable multivariable nonlinear variety independent model result integrated tool composed image analysis algorithm nonlinear approach showed highest performance robustness rpd rmse yield estimation capabilities flower number conjunction fruit set rate average berry weight also tested conclusion study proves accuracy flower number per inflorescence estimation using image analysis algorithm nonlinear model generally applicable different grapevine varieties provides fast non invasive reliable tool estimation yield harvest society chemical industry
modern industrial tote dumpers lifters equipped long stroke single rod hydraulic cylinders years valve controlled cylinders used tote dumpers valve controlled actuators highly inefficient due huge power losses throttling valves also need cooling system remove wasted heat energy hydraulic oil article introduces low cost throttle less hydraulic circuit control single rod cylinder tote dumper system consists motor driven gear pump solenoid valve redirect differential flow single rod hydraulic cylinder counterbalance valve makes circuit controllable assisting loads keeps load position effort hydraulic pump experimental results demonstrate performance circuit test rig designed simulate lifting load energy efficiency circuit determined comparing valve controlled circuit proposed circuit proposed circuit composition efficient simple also accurate terms position response using proportional controller circuit easy control since needed measurement displacement actuator circuit however recycle energy
thrombocytopenia anasarca myelofibrosis renal dysfunction organomegaly tafro syndrome variant multicentric castleman disease describe year old man presented persistent fever pleural effusion ascites negative human immunodeficiency virus human herpes virus computed tomography scan showed anterior mediastinal mass small inguinal lymphadenopathy although biopsy anterior mediastinum showed fatty tissue infiltrated cdro lymphocytes biopsy left inguinal lymph node revealed hyaline vascular type castleman disease subsequently developed severe thrombocytopenia renal dysfunction addition bone marrow biopsy showed myelofibrosis tafro syndrome diagnosed based lymph node pathology characteristic manifestations syndrome tocilizumab glucocorticoid therapy achieved complete remission regression mediastinal mass knowledge first report tafro syndrome accompanied anterior mediastinal mass responded well therapy
quality function deployment qfd wellknown method developing customer oriented products satisfying customer needs cns one important process qfd determine importance weights cns however also important estimate future importance cns existence time interval determining importance weights cns launch new products paper approach based fuzzy markov chain fuzzy weighted average methods proposed determine present future importance weights cns case study packing machine design used illustrate applicability proposed approach
paper addresses important issue intelligent transportation system namely ability vehicles safely reliably localize within priori known road map network purpose propose approach based hybrid dynamic bayesian networks enabling implement unified framework two successful families probabilistic model commonly used localization linear kalman filters hidden markov models combination two models enables manage manipulate multi hypotheses multi modality observations characterizing map matching problems improves integrity approach another contribution paper chained form state space representation vehicle evolution permits deal non linearity used odometry model experimental results using data encoders sensors dgps receiver accurate digital roadmap illustrate performance approach especially ambiguous situations
background low engagement prenatal home visiting may limit programme effectiveness improve birth outcomes multiple factors may influence engagement methods retrospective cohort study first time mothers enrolled home visiting prenatally southwest ohio primary outcome enrolment weeks gestation secondary outcome included home visit frequency two multilevel assessments conducted using random intercept multilevel modelling maternal covariates nested first within home visiting agency within zip code first model variations attributable individual agency agency volume assessed second model nested within zip code violence rates zip code interaction terms violence rates maternal factors evaluated results women enrolled weeks enrolled early received expected visits first model demonstrated significant variation early enrolment based clustering agency however agency volume significant predictor second model violence rate associated early enrolment aor interaction term maternal race significant effect increasing community violence disproportionately affected early enrolment among white women aor compared black women aor random intercept multilevel models teenagers demonstrated decreased likelihood enrolling early aor aor conclusions prenatal home visiting engagement related maternal agency community factors presenting multiple opportunities optimise programme implementation
paper provides overview state art technologies software development cloud environments surveyed systems cover whole spectrum cloud based development including integrated programming environments code repositories software modeling composition documentation tools application management orchestration work evaluate existing cloud development ecosystem based wide number characteristics like applicability programming database technologies supported productivity enhancement editor capabilities debugging tools support collaboration repository functionality version control post development application hosting compare surveyed systems conducted survey proves software engineering cloud era made initial steps showing potential provide concrete implementation execution environments cloud based applications however number important challenges need addressed approach viable challenges discussed article conclusion drawn although several steps made compact reliable solution yet exist
systematic design approach using signal flow graph sfg presented paper tailored integrated reconfigurable switched capacitor power converters achieve optimal power stage unified signal flow graph usfg model developed system transfer function impedance evaluated based verify design approach paper demonstrates step reconfigurable power converter five optional gain ratios dual loop control scheme employed reconfigure converter according instantaneous line load conditions low power digital controller designed subthreshold region feedback control loop converter fabricated cmos process experimental results show output continuously regulated allowing input voltage randomly vary line regulation maintained lowest value maximum efficiency measured output voltage load
purpose review methotrexate mtx widely used disease modifying antirheumatic drug dmard paediatric rheumatology mainstay therapy juvenile idiopathic arthritis jia despite common use children fail respond medicine results potentially irreversible joint damage recent findings clinical biomarker would predict outcome mtx therapy exists results several studies focused gene polymorphisms outcome dmard therapy published reliable genetic marker useful tailor therapy discovered far results first genome wide association study field recently revealed new genetic candidates outside metabolic pathway mtx may associated efficacy treatment summary however promising outcomes need validation independent prospective cohorts claim clinically useful biomarker predicting mtx treatment response discovered
propose new rule loop reversal block diagram signal flow graph manipulation transformation leads equivalent block diagrams signal flow graphs existing ones known algebraic loops exist systems different choices causality end different yet equivalent block diagrams signal flow graphs loop reversed versions others however author knowledge loop reversal discussed context block diagram signal flow graph manipulation still missing textbooks teaching topic
receiving average rainfall depth high intensity malaysia known tropical climate country currently malaysia proactively promotes use sustainable urban drainage syatem suds indicated malaysian stormwater management manual namely urban stormwater management manual malaysia msma version manual promoting implementation suds facilities whether single facility integrated ones combination two suds facilities however green roof included manual thus objectives paper share preliminary study intensive green roof tested high intensity rainfall using rainfall simulator four intensive green roof test bed different vegetations three species selected test bed namely kalanchoe pinnata pinnata axonopus compressus compressus arachis pintoi pintoi another test bed leave baren condition without vegetation control unit media substrate use test beds similar consists drainage cells geotextile river sand top soils parameters studied potassium total phosphate total nitrogen ammoniacal nitrogen results show pinnata performed well reduction followed pintoi compressus another studied parameters show leaching outflow test bed believed due fertilizer used plant growth term quantity control test beds showed reduction percentage runoff hydrograph range
purpose evaluate effect systemically used anti tumor necrosis factor alpha tnf alpha medication thickness corneal epithelium stroma patients ankylosing spondylitis methods total eyes participants included retrospective study three groups healthy participants group patients receiving anti tnf alpha medication group patients receiving nonsteroidal anti inflammatory medication group results according anterior segment optical coherence tomography mean thickness corneal epithelium significantly thicker group group versus stroma versus conclusions anti tnf alpha medication avoidance nonsteroidal anti inflammatory drugs could improve thickness corneal epithelium stroma patients
paper discusses modeling control ionic polymer metal composite ipmc actuators many promising applications biomechatronics novel mathematical model continuous time domain ipmc actuator stable second order dynamical system preceded nonlinear hysteresis representation proposed adaptive controller formulated ipmc actuator based proposed model proposed adaptive control law ensures global stability controlled ipmc system position error ipmc actuator theoretically guaranteed converge zero effectiveness proposed model superiority proposed control traditional proportional integral derivative control verified experimental results
background despite expansion conventional medical treatments headache many sufferers common recurrent headache disorders seek help outside medical settings aim paper evaluate research studies prevalence patient use manual therapies treatment headache key factors associated patient population methods critical review peer reviewed literature identified papers reporting findings new empirical research regarding prevalence profiles motivations communication self reported effectiveness manual therapy use amongst headache disorders results available data limited studies considerable methodological limitations use manual therapy appears common non medical treatment utilized management common recurrent headaches common reason choosing type treatment seeking pain relief high percentage patients likely continue concurrent medical care around half may disclosing use treatment medical doctor conclusions need rigorous public health health services research order assess role safety utilization financial costs associated manual therapy treatment headache primary healthcare providers mindful use highly popular approach headache management order help facilitate safe effective coordinated care
selective breeding effective tool improve livestock several selection experiments conducted study direct selection responses well correlated responses traits skeletal muscle growth function moreover comparisons domestic wild type species extreme breeds provide information genetic background skeletal muscle phenotype structural muscular components differed increasing distance lean growth meat quality mammals found myofibre number myofibre size proportions fibre types well numbers proportions secondary primary fibres furthermore markers satellite cell proliferation metabolic enzyme activities glycogen fat contents expression myosin heavy chain isoforms activated ampk alpha proteins skeletal muscle tissue circulating igf igf binding proteins identified involved selection responses observed pigs cattle chicken use molecular methods selective breeding fish recently adopted aquaculture studies genetic basis growth flesh quality traits scarce molecular markers muscle structure metabolism livestock also identified fish far studies linked selection response genome scans applied identify genomic regions exhibiting quantitative trait loci control traits interest example muscle structure meat quality pigs growth rate chicken another approach polymorphisms candidate genes reveal relationship genetic variation target traits thus large scale studies pigs associations polymorphisms hmga epor nme ttn genes traits carcass meat quality detected studies revealed significance mutations igf ryr genes carcass lean muscle fibre traits pigs mutations myostatin mstn gene fish also examined advances research genetic environmental control traits related meat quality growth made application holistic omics techniques studied whole muscle specific genome transcriptome proteome relation muscle meat traits development new methods muscle fibre typing adaptation biophysical measures develop parameters muscle fibre traits well application vitro studies finally future research priorities field defined
reducing latency distributed computing data storage systems gaining increasing importance several empirical works reported efficacy scheduling redundant requests systems one may reduce job latency scheduling job one server waiting fastest responds several theoretical models proposed explain power using redundant requests existing results rely heavily common assumption redundant requests job immediately cancelled soon one completed study one schedule redundant requests assumption hold great importance practice since cancellation running jobs typically incurs non negligible delays order bridge gap existing models practice propose new queueing model captures cancellation delays find one schedule redundant requests achieve optimal average job latency new model results show even small cancellation overhead actual optimal scheduling policy differs significantly optimal scheduling policy overhead zero furthermore study optimal dynamic scheduling policies appropriately schedule redundant requests based number jobs system analysis reveals two server case optimal dynamic scheduler achieve lower average job latency compared optimal static scheduler
safety climate snapshot safety culture organization dynamic nature reflects employees perceptions attitude towards existing safety practices construction projects main goal paper evaluate differentiate construction projects based safety climate determine significant constructs safety climate paper develops model predict safety climate construction project based artificial neural network ann important constructs safety climate determined literature review constructs safety climate used inputs safety climate project used output ann algorithm study collected total responses questionnaire survey across country three layer feed forward back propagation neural network utilized analysis developed model predicts safety climate construction project reasonably well based sensitivity analysis commitment supervisory environment proposed significant constructs safety climate moreover projects ranked respect safety climate using model outlier projects could easily identified normal probability technique thus model prove helpful clients contractors evaluate predict safety climate thereby managing safety effectively construction projects american society civil engineers
teams working development software systems use certain tools workflows product knowledge management tools workflows help plan monitor control product stages product lifecycle well capture develop share project related knowledge paper discusses tools workflows development teams german national library science technology tib use developing web portals use case illustrated project interaction concept screen design video portal tib tib vertical bar portal adapted new look feel main portal tib portal course project team gathered structured preliminary requirements enterprise wiki created axure user interface prototype evaluated prototype specified requirements using sprints scrum framework commissioned external screen designers software developers create new screen design based prototype implement requirements tested implementations collaborative workflow approved deployment debugging
chinese agriculture developing fast towards industrial food production systems discharge nutrient rich wastewater rivers result nutrient export rivers increasing resulting coastal water pollution developed model assess river inputs nutrients seas marina china marina nutrient model quantifies river export nutrients source sub basin scale function human activities land marina downscaled version china global news nutrient export watersheds model improved approach nutrient losses animal production population use model quantify dissolved inorganic organic nitrogen phosphorus export six large rivers draining bohai gulf yellow hai liao yellow sea yangtze huai south china sea pearl addressed uncertainties marina nutrient model river export dissolved increased factor depending sea nutrient form thus risk coastal eutrophication increased direct losses manure rivers contribute nutrient inputs bohai gulf nutrient inputs seas sewage important source dissolved inorganic synthetic fertilizers dissolved inorganic half nutrients exported yangtze pearl rivers originated human activities downstream middlestream sub basins yellow river exported dissolved inorganic downstream sub basins dissolved organic middlestream sub basins rivers draining bohai gulf drier thus transport fewer nutrients future calculate increases river export nutrients marina nutrient model quantifies main sources coastal water pollution sub basins information contribute formulation effective management options reduce nutrient pollution chinese seas future authors published elsevier
article examines sociocultural conditions underpinning called abortion culture soviet ukraine unlike previous studies abortion soviet union primarily used country level data study employs original sources depth biographical interviews archival materials investigate local conditions manner decisions regarding abortion made author studied couples whose reproductive years comprise period modern contraceptives readily available abortion legal two localities ukraine cities lviv kharkiv included investigation findings suggest local patriarchal gender regimes associated spousal dynamics defined women exercised agency birth control abortion decisions couples spouses communicated birth control abortion decisions women sought less abortions women feel need exercise agency husband took responsibilities abortion practised routine family size limitation method spouses communicate birth control abortion two practised solely husband wife responsibility respectively women sought abortions fulfil goals time maintain dominant patriarchal order marital relationships understood additionally peer networks seemed crucial element reinforcing women agency processes
role androgens cardiovascular disease still controversial men study investigated metabolic disorders tunisian hypogonadal men compared healthy controls forty hypogonadal men control subjects enrolled patients history pre existing panhypopituitarism thyroid dysfunction inflammatory disease excluded glycaemia glycated haemoglobin hbac high sensitive reactive protein hscrp lipid profile insulin testosterone gonadotrophins measured insulin resistance assessed homoeostasis model assessment insulin resistance homa waist circumference body mass index blood pressure significantly higher patients compared controls glycemia hbac fasting serum insulin homa significantly increased among hypogonadal men univariate analysis testosterone levels inversely correlated body mass index waist circumference blood pressure glycaemia hbac insulin homa hscrp multivariate analysis including significant variables initial testosterone level independent risk factor developing dyslipidaemia logistic regression male hypogonadism independent risk factor conclude low testosterone level plays central role development metabolic syndrome prospective data required establish causative link
paper introduces new method improve reliability confidence level defect depth measurement based pulsed thermographic inspection addressing fitting problem different existing methods using fixed model structure pixels proposed method adaptively detects optimal model structure pixel thus targeting achieve better model fitting using less model terms results numerical simulations real experiments suggest new method able measure defect depth accurately without pre set model structure error usually within snr comparison existing methods number model terms signals snr epsilon snr snr data length least data points times characteristic time usually produces best results authors published elsevier ltd
calpains family intracellular cysteine proteases involved various biological processes previously family identified abnormal expression several types malignant tumor calpain less well known however recently identified involved carcinogenesis certain types malignant tumor however expression calpain head neck squamous cell carcinoma hnscc remains unclear total six datasets gene expression omnibus geo analyzed association calpain expression levels hnscc identified expression calpain observed significantly decreased hnscc however expression calpain may vary distinct tumor stages hnscc furthermore calpain expression positively associated survival rate patients hnscc increased expression calpain associated improved survival outcome calpain expression analyzed using hnscc tissue microarray results consistent statistical analysis bioinformatics data geo indicating calpain may tumor suppressor protein hnscc
general algorithm derive transfer functions discrete systems presented given discrete system arbitrary order arbitrary topology structure analyzed construct algorithm nodal equations dft signal flow graph resetting algorithm develop computer aid analysis software deriving transfer function discrete system example analyzing lattice digital filter shows algorithm valid
situation prediction increasingly important focus network security information incoming security situation network important helps network administrator make good decisions taking defense remedies towards attack exploitation although grey verhulst prediction model demonstrated satisfactory results fields investigations still required improve performance predicting incoming network security situation order attain higher predictive accuracy existing grey verhulst prediction models paper tends seek enhancement adaptive grey verhulst security situation prediction model forecasting incoming residual based historical prediction residuals proposed model applied kalman filtering algorithm predict residual next time frame closer deviation predicted actual network security situation benchmark datasets darpa used verify accuracy proposed model results shown enhanced adaptive grey verhulst prediction model better prediction capability predicting incoming network security situation also achieved significant improvement compared grey verhulst prediction models
december china food drug administration cfda approved first inactivated enterovirus whole virus vaccine preventing severe hand foot mouth disease hfmd one preventive vaccines children infectious diseases generated developing countries recent years vaccine blessing children health china worldwide however still challenges facing worldwide use vaccine including applicability various pandemic strains countries international requirements vaccine production quality control standardization harmonization different pathogen monitoring detecting methods etc addition affordability vaccine countries factor considered hfmd prevention therefore vaccine commercially available still long way reaching effective protection severe hfmd vaccines enter market paper bottlenecks prospects wide use vaccine approval evaluated
development scaffolding materials clinical applications depends thorough understanding mechanics tissue material interaction mechanical failure failure strength materials key role performance particularly load bearing applications ideal scaffolding material physical mechanical properties close possible tissue replaced time supporting cell adhesion growth maintaining shape regarding synthetic polymers used scaffold preparation polyvinyl alcohol pva one first synthetic macromolecules tested produce spongy matrices tissue regeneration pva broad applications including tissue mimicking vascular cell culture vascular implanting heart valves cartilage substitute contact lenses corneal implants however lack sufficient data mechanical failure pva based materials brings limited application pva tissue engineering applications study biomechanical method used characterize mechanical failure fabricated pva sponge sponge compared two commercially available sponges cenefom eyetec using biaxial puncture testing machine revealed failure stress sponge higher cenefom eyetec sponges hoped mechanical information obtained provide insight biomechanical approaches elucidate potential causes early rupture suggest future treatments prevention mechanical failure pva sponges used scaffolding materials
colleges tourism management professional education times accelerate pace reform according urgent requirements international domestic tourism management professionals overall quality construction management tourism professionals personnel training targeted scientific applications type level develop teaching programs security emphasize development talent market needs qualified personnel build tourism management professional practice teaching system pay attention students practical abilities college tourism management education foster solid foundation practical ability high quality integrated suit national local economic social development needs senior applied talents sustained rapid healthy coordinated development china tourism industry provide personnel protection
study aims define imaging findings patient demographics patient provider interactions health care practices may affect woman decision follow setting rads category total women university arizona breast imaging center rads category assessment mammography ultrasound findings evaluated february june demographic information analyzed patients regardless follow women returned follow within recommended time period given one survey time follow appointment women returned follow later recommended given separate survey complete age palpability lesion menopause status related follow self rated general health factor found associated decision follow time majority patients followed time reported mailed reminder cards primary practice prompted follow patients followed later recommended major reason time findings suggest additional counseling regarding benefits short interval imaging follow might advantageous patients
family bamboo like metal organic nanotubes consisting situ synthesized macromolecular blocks reported mbs composed six fac cores one benzene hexaolate plate six pyridine derivative pillar ligands doubly tri legged geometry mutually assembled piece piece entire system characterized simple precise supramolecular complexation macromolecular blocks introduces archetypal approach systematically constructing tunable form dissectible molecular bamboo tubes
serotonin regulates wide variety brain functions behaviors synthesize previous findings serotonin regulates executive function sensory gating social behavior attention deficit hyperactivity disorder bipolar disorder schizophrenia impulsive behavior share common defects functions remained unclear supplementation omega fatty acids vitamin improve cognitive function behavior brain disorders propose mechanisms serotonin synthesis release function brain modulated vitamin marine omega fatty acids eicosapentaenoic acid epa docosahexaenoic acid dha brain serotonin synthesized tryptophan tryptophan hydroxylase transcriptionally activated vitamin hormone inadequate levels vitamin similar population omega fatty acids common suggesting brain serotonin synthesis optimal propose mechanisms epa increases serotonin release presynaptic neurons reducing series prostaglandins dha influences serotonin receptor action increasing cell membrane fluidity postsynaptic neurons propose model whereby insufficient levels vitamin epa dha combination genetic factors key periods development would lead dysfunctional serotonin activation function may one underlying mechanism contributes neuropsychiatric disorders depression model suggests optimizing vitamin marine omega fatty acid intake may help prevent modulate severity brain dysfunction
recent studies construction material technology indicated soil reinforcement improves resistance soil compression tension due wide use geotextile reinforcement road construction potential benefit geotextile reinforcement cyclic loading investigated study performed series cyclic triaxial tests examine dry silty sand reinforced geotextile subjected dynamic loading tests conducted reinforced unreinforced dry sand sand mixed varying amounts silt main factors affecting cyclic behaviour arrangement number geotextile layers confined pressure silt content examined discussed paper results indicate geotextile inclusion increased confining pressure increase axial modulus decreased cyclic ductility dry sand silt contents examined also found increasing silt content percent axial modulus reinforced unreinforced sand decreased cyclic ductility increased increases silt content values increased cyclic axial modulus decreased cyclic ductility elsevier ltd rights reserved
several immunologic mediators phosphodiesterase pde interleukin small molecules janus kinase implicated pathogenesis atopic dermatitis evidence shown blocking mediators help modify disease process several new topical medications developed target enzyme pde crisaborole recently approved food drug administration fda treatment atopic dermatitis phase studies completed opa phase iii clinical trial results systemic medication dupilumab inhibitor receptor subunit inhibits signaling currently reviewed fda published frontline medical communications
background mucormycosis rare devastating fungal infection primarily affecting immunocompromised patients hematological malignancy bone marrow solid organ transplantation patients diabetes even rarely immunocompetent patients objective study assess prevalence burden clinical economic mucormycosis among hospitalized patients methods retrospective study using premier perspective comparative database participating hospitals covering million patients january june hospitalizations database evaluated presence mucormycosis using either icd code positive laboratory result mucorales hospitalizations required prescriptions amphotericin posaconazole considered mucormycosis related hospitalizations prevalence mucormycosis related hospitalizations among hospital discharges estimated mortality rate discharge length hospital stay readmission rates months evaluated among mucormycosis related hospitalizations cost per hospital stay average per diem cost inflated usd reported results prevalence mucormycosis related hospitalizations estimated per discharges january june increased per discharges definition mucormycosis relaxed require use amphotericin posaconazole median length stay days dead discharge readmission rates high patients readmitted within one three months discharge respectively average cost per hospital stay average per diem cost conclusions study provides recent estimate prevalence burden mucormycosis among hospitalized patients high clinical economic burden associated mucormycosis highlights importance establishing active surveillance optimizing prophylactic active treatment susceptible patients
cardiac vagal control cvc linked physical mental health one critical aspect health received much attention sleep hypothesized adults higher cvc operationalized high frequency heart rate variability hrv exhibit better sleep quality assessed subjectively pittsburgh sleep quality index objectively polysomnography hrv measured healthy young women extended neutral film clip participants underwent full polysomnography obtain objective measures sleep quality hrv night sleep expected higher resting hrv associated higher subjective objective sleep quality shorter sleep latency fewer arousals hrv sleep overall separated sleep phases showed less consistent relationships sleep quality findings indicate high waking cvc may key predictor healthy sleep authors published elsevier open access article license http creativecommons org licenses
non invasive invasive electroneurostimulation ens modalities bladder bowel dysfunction studied reported children summary proposed mechanism actions commonly used recently reported techniques outcomes described includes transcutaneous electrical nerve stimulation functional electrical nerve stimulation intravesical electrical nerve stimulation percutaneous tibial nerve stimulation sacral neuromodulation conditions including overactive bladder enuresis dysfunctional voiding constipation combined bladder bowel dysfunction neuropathic bladder bowel dysfunction need high quality randomised trials well long term outcomes establish whether ens able alter long term trajectory individual child bladder bowel dysfunction crown copyright published elsevier ltd behalf european paediatric neurology society rights reserved
aimsto investigate role pfc micturition reflex using vivo microdialysis study rats methodsadult female sprague dawley rats used microdyalysis pfc cystometrography cmg performed consciousness free movement present study experiment samples including extracellular neurotransmitters collected microdyalysis analyzed high performance liquid chromatography time cmg performed measure intercontraction interval ici maximum voiding pressure mvp experiment ssri citalopram administered pfc microdyalysis cystometrography cmg performed simultaneously experiment following ssri administration hta agonist dpat effect decreasing level serotonin pfc administered pfc microdyalysis cmg performed simultaneously resultsexperiment extracellular level pfc significantly increased micturition reflex whereas levels glutamate dopamine significantly changed experiment local administration ssri pfc increased level approximate basal level also significantly increased ici whereas significant change found mvp experiment extracellular level gradually decreased local administration hta agonist thereby ici significantly decreased conclusionsthe results present study suggest pfc suppressive effect neural control micturition reflex via serotonin neurourol urodynam wiley periodicals inc
purpose review critically evaluate summarize studies published july june linking prenatal exposures onset childhood wheezing illnesses discuss future research directions field recent findings aggregated evidence indicates consistent detrimental effect prenatal exposure parental smoking outdoor air pollution maternal stress childhood wheezing illnesses less consistent evidence suggests adverse impact maternal obesity pregnancy prenatal exposure antibiotics outcomes insufficient evidence support association utero exposure acetaminophen prenatal levels specific nutrients vitamin folic acid polyunsaturated fatty acids childhood wheezing illnesses summary several common potentially modifiable prenatal exposures appear consistently associated childhood wheezing illnesses parental smoking outdoor air pollution maternal stress however effect many prenatal exposures onset childhood wheezing illnesses remains unclear existing scientific evidence past year allow make new recommendations primary prevention measures intervention studies best demonstrate whether changing prenatal environment prevent childhood wheezing illnesses asthma
purpose investigate alterations mitochondria irradiated endothelial cells elucidate mechanism underlying radiation induced heart disease materials methods experiments performed using human umbilical vein endothelial cells huvecs huvecs irradiated single gamma ray dose respectively apoptosis assessed flow cytometry post irradiation respectively intracellular reactive oxygen species ros measured dichlorofluorescein diacetate dcfh post irradiation mitochondrial membrane potential opening mitochondrial permeability transition pore mptp calcein cobalt quenching method detected post irradiation order measure changes mitochondria induced gamma ray irradiation results gamma ray irradiation increased huvecs apoptosis dose dependent time dependent manner irradiation also promoted ros production huvecs dose dependent manner post irradiation results showed irradiation decreases however paradoxically flow cytometry showed green fluorescence instensity higher irradiated huvecs control huvecs irradiation dose dependent manner indicated gamma ray irradiation inhibited mptp opening huvecs conclusions gamma ray irradiation induces apoptosis ros production endothelial cells decreases meanwhile contradictorily inhibiting opening mptp
study methodology presented demonstrated combined estimation regional specific yield distributed recharge using double water table fluctuation dwtf technique geographical information system gis hard rock aquifer system semi arid regions study area divided zones groundwater budget components computed wet dry seasons using year period data zone regional specific yield estimated applying wtf technique dry seasons rainfall recharge estimated applying wtf technique wet seasons zone wise rainfall recharge relationships established using regression technique thereafter specific yield recharge estimates used gis generate maps surface water bodies found significantly contribute groundwater recharge finding underscores need adopting rainwater harvesting study area enhance recharge regional specific yields found range whereas mean rainfall recharge found vary box whisker plots scale transformed specific yield revealed greatest spatial variation spatial temporal variations rainfall recharge study area statistically significant developed rainfall recharge relationships found highly significant ten zones insignificant remaining zones international association hydro environment engineering research asia pacific division published elsevier rights reserved
theory inventive problem solving triz one emerging creative problem solving methodologies paper proposes way simplify triz electrical domain usage making feel less complex relevant understand able users specific sector research takes dynamic voltage restorer dvr device case electrical engineering domain demonstrate proposed triz based guidance framework development assist solving problems dvr devices proposed sector specific guidelines particular segment electrical engineering power quality device dvr closer comprehensible particularly linked key parameters sector using derived guidance framework field engineers basic triz knowledge may apply triz confidently design problem solving purpose
manufacturing engineering several areas knowledge focused study manufacturing processes give rise products supplied processing industries products final consumers processed sheet wires rods beams cases one widely used manufacturing processes metal forming mechanical process pieces obtained compression solid metal molds using plastic deformation material filling molds cavities however process without need molds called incremental sheet forming consists drawing workpiece cnc form milling using small cylindrical punch rounded tip purpose work make study process incremental sheet forming polymers new type rapid prototyping technology based process forming material different existing processes removing adding material tests done geometry pyramid trunk format three subsequent stages objective evaluate parameters temperature working punch diameter final result prototype material chosen study pvc present many studies already done subject tests made pvc indicated variation degrees material working temperature resulted significant increase forming results tests
novel permanent magnet machine counterrotating dual rotors pmcdr proposed order improve operation performance underwater vehicle anti rotation propulsion system substantially simplify system structure decrease volume reduce mass cost moreover improve reliability without brush slip ring idea principle electromagnetic design provided order meet power angle characteristic corresponding uniform similar inner rotor permanent magnet machine unit irpmu outer rotor permanent magnet machine unit orpmu magnetic field stator yoke flux density air gap flux density inductance load back emf torque angle characteristic obtained finite element method prototype designed built tested method detecting load back emf search coils proposed validity verified fea results experimental measurements
paper discusses main issues generally found protection systems low voltage electrical installations presents methodology used analyze upgrade existing power system protective devices low voltage distribution systems upgrades existing operating systems especially low voltage systems always face economic challenge monetary value spent upgrades justifiable benefit derived understood clearly benefit upgrades existing protective systems larger making systems safer gated approach upgrade proper management systems help planning future expansions provide reliability equipment decrease overall risk operation facility
objective earlier analyses nonhispanic white women found stronger relation abuse history midpregnancy elevated depressive symptoms women serotonin transporter httlpr genotype focus african american women inquiry motivated racial differences depression diagnosis treatment stressors frequency major httlpr alleles materials methods stressful life events lifetime depressive symptoms current ascertained weeks gestation center epidemiological studies depression score equal considered elevated life events scored together separated six subconstructs httlpr genotypes grouped follows alleles equivalence triallelic biallelic iii others high intermediate low odds ratios elevated depressive symptoms life events total subconstructs relations calculated genotype grouping results prevalence elevated depressive symptoms vary genotype relation stressful life events elevated depressive symptoms stronger compared genotype interaction six subconstructs abuse showed statistically significant gene environment interaction abuse elevated depressive symptoms association greater genotype interaction triallelic biallelic grouping interaction high intermediate low grouping low higher intermediate high ors interaction conclusions results show importance examining racial groups specific stressful events different httlpr genotype groupings exploring gene environment interactions depression psychiatr genet wolters kluwer health lippincott williams wilkins psychiatric genetics
childhood maltreatment key risk factor poor mental physical health recently variation epigenetic processes dna methylation emerged potential pathway mediating association yet extent different forms maltreatment may characterized unique shared epigenetic signatures currently unknown study quantified dna methylation across genome buccal epithelial cell samples high risk sample inner city youth age female reported experiencing least one form maltreatment growing analyses aimed identify methylomic variation associated exposure five major types childhood maltreatment found maltreatment types differ extent associate methylomic variation physical exposures showing strongest associations many identified loci annotated genes previously implicated stress related outcomes including psychiatric physical disorders gabbr grind cacnad psen iii based gene ontology analyses maltreatment types show unique methylation patterns enriched specific biological processes physical abuse cardiovascular function also share common epigenetic signature enriched biological processes related neural development organismal growth stringent set sensitivity analyses also run identify high confidence associations together findings lend novel insights epigenetic signatures childhood abuse neglect point novel potential biomarkers future investigation support molecular link maltreatment poor health outcomes nevertheless important future replicate findings use cross sectional data high rates polyvictimization study make difficult fully disentangle shared unique epigenetic signatures maltreatment types furthermore studies needed test role potential moderators identified associations including age onset chronicity maltreatment exposure elsevier ltd rights reserved
hyperspectral remote sensing data offer opportunity map urban characteristics detail though adequate algorithms need cope increasing data dimensionality high redundancy individual bands often spectrally complex urban landscapes study focuses subpixel quantification urban land cover compositions using simulated environmental mapping analysis program enmap data acquired city berlin utilizing machine learning regression classification algorithms multioutput support vector regression msvr standard support vector regression svr import vector machine classifier ivm support vector classifier svc experimental setup incorporates spectral library reference land cover fraction map used validation purposes library spectra synthetically mixed derive quantitative training data classes vegetation impervious surface soil water msvr svr models trained directly using synthetic mixtures ivm svc modified hyperparameter selection approach conducted improve description urban land cover fractions means probability outputs validation results demonstrate high potential msvr subpixel mapping urban context msvr outperforms svr terms accuracy computational time ivm svc work similarly well yet lower accuracies subpixel fraction estimates compared regression approaches
urgent problems power industry century require creation smart energy systems providing high effectiveness generation transmission consumption electric power simultaneously requirements controllability power systems ecological resource saving characteristics stages production distribution electric power increased one decision methods many problems power industry development new high efficiency electrical equipment smart power systems based superconducting technologies ensure qualitatively new level functioning electric power industry intensive research development new types electrical devices based superconductors carried many industrialized advanced countries interest developments especially increased recent years owing discovery called high temperature superconductors hts require complicated expensive cooling devices devices operate cooling inexpensive easily accessible liquid nitrogen taking account obvious advantages superconducting cable lines transmission large power flows electrical network compared conventional cables federal grid company unified energy system jsc fgc ues initiated research development program including creation superconducting hts cable lines two cable lines transmitted power mva manufactured tested within framework program
post exertion malaise one debilitating aspects myalgic encephalomyelitis chronic fatigue syndrome yet neurobiological consequences largely unexplored objective study determine neural consequences acute exercise using functional brain imaging fifteen female myalgic encephalomyelitis chronic fatigue syndrome patients healthy female controls completed min submaximal exercise peak heart rate cycle ergometer symptom assessments fatigue pain mood brain imaging data collected one week prior following exercise functional brain images obtained performance fatiguing cognitive task paced auditory serial addition task non fatiguing cognitive task simple number recognition non fatiguing motor task finger tapping symptom exercise data analyzed using independent samples tests cognitive performance data analyzed using mixed model analysis variance repeated measures brain responses fatiguing non fatiguing tasks analyzed using linear mixed effects cluster wise voxels alpha myalgic encephalomyelitis chronic fatigue syndrome patients reported large symptom changes compared controls effect size however patients exercised significantly lower watts reported greater exertion leg muscle pain cognitive performance significant group time interaction demonstrated pre post exercise improvements controls worsening patients brain responses finger tapping differ groups either time point number recognition controls exhibited greater brain activity posterior cingulate cortex pre exercise scan paced serial auditory addition task significant group time interaction patients exhibiting increased brain activity pre postexercise compared controls bilaterally inferior superior parietal cingulate cortices changes brain activity significantly related symptoms patients acute exercise exacerbated symptoms impaired cognitive performance affected brain function myalgic encephalomyelitis chronic fatigue syndrome patients converging results linking symptom exacerbation brain function provide objective evidence detrimental neurophysiological effects post exertion malaise published elsevier inc open access article license
paper going investigate insulin bio molecule responsible onset diabetes generally diagnosed using conventional elisa method picomolar concentration blood short life time challenge developing sensor sensitive small volumes paper presents experimental study dielectric properties hepes buffer solution varying concentration insulin peptide hormone microwave frequency range composite whispering gallery electric mode wge microwave dielectric resonator sapphire polycarbonate disposable sample holding disc used ghz observations imaginary part permittivity found sensitive changes insulin concentration ranging studies show present method potential detect sense ultralow concentration bioanalyte regression coefficient sensitivity change insulin concentration
eye gaze powerful signal exerts mixture arousal attentional social effects observer recently found behavioural interaction eye contact mimicry direct gaze rapidly enhanced mimicry hand movements report two detailed investigations effect experiment compared effects direct gaze averted gaze gaze acting hand mimicry manipulated sequence gaze events within trial direct gaze immediately hand action enhanced mimicry experiment examined enhancement mimicry direct gaze followed blink shut eyes occluded eyes enhanced mimicry relative baseline seen blink condition together results suggest ongoing social engagement necessary enhanced mimicry findings allow place gaze enhancement effect context reported gaze phenomena suggest effect similar previously reported audience effects less similar ostensive cueing effects important implications theories relationships social cues imitation
potential influence video game violence real world aggression generated considerable public scientific interest previous research suggests playing violent video games increase postgame aggression generalized aggression model gam attributes generalized activation aggressive schemata however unclear whether game mechanics contextualize encourage inhibit game violence moderate relationship thus examined effects reward structures narrative context violent video game game postgame aggression contrary gam based predictions manipulations differentially affected game postgame aggression reward structures selectively affected game aggression whereas narrative context selectively affected postgame aggression players enacted game violence heroic character exhibited less postgame aggression players enacted comparable levels game violence antiheroic character effects attributable self activation character identification mechanisms consistent social cognitive context effects interpretation behavior results contradict gam assertion violent video games affect aggression generalized activation mechanism applied perspective consumer choices may aided considering game content context content portrayed
recent controversial hypothesis suggests presence oestrus phase women mammals implies women optimal fertility point menstrual cycle exhibit behaviors focused maximize genetic quality offspring several studies support hypothesis finding women fertile phase tend prefer men traits associated phenotypic quality greater facial masculinization symmetry experimentally tested observations supporting hypothesis population young spanish women analyzed whether preference masculinized male faces affected phase menstrual cycle stable partner use birth control pills could reproduce effect first two factors found women using hormonal contraceptives tend prefer men less masculine faces results indicate evidences supporting oestrus hypothesis humans must reviewed incorporating data different socio cultural ethnic populations
studied occurrence presentation disease course effect adjunctive dexamethasone prognosis bacterial meningitis patients using immunosuppressive medication patients selected nationwide prospective cohort community acquired bacterial meningitis performed march october eighty seven episodes bacterial meningitis occurred patients using immunosuppressive medication consisted corticosteroids patients bacterial meningitis using immunosuppressive medication less likely present headache neck stiffness compared immunosuppressive medication episodes csf leukocyte count csf cultures revealed pneumoniae monocytogenes episodes outcome unfavorable episodes death occurred episodes adjunctive dexamethasone administered episodes mortality tended lower adjunctive dexamethasone therapy compared without dexamethasone therapy conclude bacterial meningitis patients using immunosuppressive medication likely present atypical clinical laboratory features often caused atypical bacteria mainly monocytogenes adjunctive dexamethasone widely prescribed patients associated harm study
stabilizing pid controllers class unstable plants time delays delays obtained utilizing approach methods given aim investigate appropriate pid controllers finding maximum allowable boundaries parameter work consider model flexible robot arm includes time delay integrator aim find optimal coefficients derivative integral gain designs achieve set performance robustness objectives stability robustness properties closed loop system also investigated specifically optimal derivative action gain determined maximize allowable controller gain interval controller controller optimal proportional gain determined maximize lower bound largest allowable integral action gain words utilize method helps find optimal boundaries investigating proper proportional gain parameter
young latino gay bisexual men experience discrimination due heterosexism racism within beyond communities although research emphasised overt forms discrimination growing body research examining effects microaggressions indirect forms discrimination racial sexual minorities purpose study explore contexts various types microaggressions well describe resilience strategies used young adult latino gay bisexual men living los angeles california sample young latino gay bisexual men aged years recruited complete qualitative depth semi structured interviews following phenomenological approach three contextual themes relevant microaggressions emerged microassaults microinsults microinvalidations three themes emerged around resilience strategies overcome experiences self discovery adaptive socialisation self advocacy family community based efforts reinforce expand resilience repertoires needed help young latino gay bisexual men resumeles jeunes hommes latinos gays bisexuels sont victimes discriminations raison heterosexisme racisme existant sein dela leur communaute plupart des etudes ont mis accent sur les formes manifestes discrimination nombre croissant recherches examine les effets micro agression des formes indirectes discrimination sur les minorites raciales sexuelles objectif cette etude etait explorer les contextes des divers types micro agression ainsi que decrire les strategies resilience adoptees par les jeunes latinos gays bisexuels vivant los angeles jeunes issus cette population ages ans ont ete recrutes pour participer des entretiens qualitatifs profondeur semi structures conduits dans une approche phenomenologique trois themes contextuels relevant micro agression ont emerge les micro assauts les micro insultes les micro invalidations trois themes ont emerge relativement aux strategies resilience adoptees pour surmonter ces experiences auto decouverte socialisation adaptive autonomie sociale des efforts fondes sur famille communaute visant renforcer elargir repertoire des strategies resilience sont necessaires pour aider les jeunes hommes latinos gays bisexuels resumenlos hombres jovenes homosexuales bisexuales origen hispano sufren discriminacion debido heterosexismo racismo dentro fuera sus comunidades aunque mayoria los estudios hecho hincapie las formas evidentes discriminacion cada vez mas estudios analizan los efectos micro agresion formas indirectas discriminacion minorias raciales sexuales finalidad este estudio fue analizar los contextos varios tipos micro agresion asi como describir las estrategias resiliencia que utilizan los hombres jovenes adultos homosexuales bisexuales origen hispano que viven los angeles california capto una muestra hombres jovenes homosexuales bisexuales origen hispano con edades comprendidas entre los los anos para participar entrevistas semiestructuras cualitativas exhaustivas con enfoque fenomenologico surgieron tres temas contextuales que eran relevantes para micro agresion micro asaltos micro insultos micro invalidaciones surgieron tres temas como estrategias resiliencia para superar estas experiencias autodescubrimiento socializacion adaptable autodefensa sus derechos necesario apoyo familia comunidad para fortalecer ampliar los repertorios resiliencia con fin ayudar los hombres jovenes homosexuales bisexuales origen hispano
goal paper model analyze properties respiratory system means fractional calculus linear fractional order system commensurate order obtained using real imaginary parts measured respiratory impedance identification technique context features used classification respiratory diseases identified parameters linear fractional order system commensurate order features classified using nearest neighbors knn classifier proposed method achieved accuracy using first feature however using features accuracy increased proposed classification technique validated patients healthy asthma chronic obstructive pulmonary disease copd elsevier ltd rights reserved
stereotype threat often incurs cost reducing amount information older adults accurately recall current research tested whether stereotype threat also benefit memory according regulatory focus account stereotype threat threat induces prevention focus people become concerned avoiding errors commission sensitive presence absence losses within environment predicted stereotype threat might reduce older adults memory errors results consistent prediction older adults stereotype threat lower intrusion rates free recall tests experiments also reduced false alarms adopted conservative response criteria recognition test experiment thus stereotype threat decrease older adults false memories albeit cost fewer veridical memories well
paper starts revisiting founding classical ideas neural networks artificial intelligence devices basic functionality devices given stability related properties gradient like collective qualitative behaviors properties linked structural connectionist approach version approach offered hyperstability theory presented brief essentials paper hyperstability isolated hopfield neuron interconnection neurons hyperstable structures discussed shown called triplet neurons good stability properties non symmetric weight matrix suggests new approaches developing artificial intelligence devices based triplet interconnection elementary systems neurons order obtain new useful emergent collective computational properties
study realize current mode multifunction filters three new circuit configurations presented circuits include fully differential current conveyor fdccii four passive components first proposed circuit universal filter single input three outputs simultaneously realize current mode low pass band pass high pass filter responses employing grounded passive components last two proposed universal filters three inputs single output realize current mode low pass band pass high pass band stop pass filter responses employing single fdccii furthermore proposed circuits still enjoys realization using minimum number active passive components first last proposed circuits requirement component choice conditions realize specific filtering functions parameter matching condition required active passive sensitivities filters investigated calculated percentage hangings simulation results found close agreement theoretical results
seems common understanding norwegian construction industry faces challenges concerning presence delays defects handover process however little research found regarding countermeasures avoid problems paper forms part research project handover processes norwegian construction projects initiated municipality trondheim supposed work pilot study research examines consequences delays defects causes potential countermeasures implemented case studied expansion shopping centre norway complex project structurally organisationally addition literature review documentation study nine semi structured depth interviews conducted interviews case specific client contractor user representatives respectively consequences delays defects severe resulted additional costs lower quality final product psychological strain involved actors short construction period diffuse contractual relationships lack quality assurance high degree alteration work found constitute crucial causes basis observed challenges different countermeasures suggested building commissioning realistic project plans control deliveries independent control recommended countermeasures findings indicate great potential improvement keeping control throughout whole project experiments needed substantiate recommendations paper authors published elsevier ltd
pursuit identify reversible selective btk inhibitors two series based pyrrolo pyrimidine pyrrolo pyridine hinge binding core identified structure activity relationship sar exploration led identification two advanced lead molecules demonstrated desired btk inhibitory potency different cellular assays excellent selectivity panel diverse kinases favorable vivo properties mice anti arthritic effect mouse model cia elsevier ltd rights reserved
programmed death ligands namely one key factors responsible inhibitory cell signaling mediating mechanisms tolerance providing immune homeostasis mounting evidence demonstrates impaired function plays important role variety autoimmune diseases type diabetes encephalomyelitis inflammatory bowel diseases ibd rheumatoid arthritis autoimmune hepatitis aih behcet disease myasthenia gravis autoimmune uveitis sjogren syndrome sjs systemic lupus erythematosus sle systemic sclerosis ssc myocarditis ankylosing spondylitis investigating candidate genes genome wide association studies identification single nucleotide polymorphisms snps gene humans shown higher risk relevant genetic associations developing autoimmune diseases certain ethnic groups review tried present comprehensive role recently studied autoimmune diseases elsevier inc rights reserved
paper propose three dimensional two level locality aware parallel delaunay image mesh conversion algorithm lapd algorithm exploits two levels parallelism different granularities coarse grain parallelism region level mapped node multiple cores medium grain parallelism cavity level mapped single core employ data locality aware mesh refinement process reduce latency caused remote memory access evaluated lapd blacklight cache coherent numa distributed shared memory dsm machine pittsburgh supercomputing center observed weak scaling efficiency almost roughly cores compared previous algorithm parallel optimistic mesh generation algorithm podm best knowledge lapd exhibits best scalability parallel delaunay mesh generation algorithms running numa dsm supercomputers elsevier rights reserved
numerical model developed system consisting liquid slug vapour plug oscillating tube closed one end connected reservoir constant pressure end represents basic configuration pulsating heat pipe php thermally driven self sustained oscillations system result evaporation condensation phenomena occurring two zones tube separated adiabatic section one cooled heated simultaneously modelling principles system posed previous works work equation describing liquid film evaporation substantially improved light recent experimental results thickening film shortening length due evaporation triple line taken account furthermore transient heat conduction equation solved tube liquid film order calculate temperature evaporator key parameter model moreover experimental bench presented measure pressure variations inside oscillating liquid slug results show classical correlations fluid mechanics relevant model oscillation system finally parametric study carried understand influence thermal properties liquid tube start system thermal effusivity materials found important criterion indicate conditions oscillations commence relain self sustained elsevier masson sas rights reserved
vera virtual environment reactor applications system physics capabilities developed deployed consortium advanced simulation light water reactors casl casl established modeling simulation commercial nuclear reactors vera consists integrating interfacing software together suite physics components adapted refactored simulate relevant physical phenomena coupled manner vera also includes software development environment computational infrastructure needed components effectively used describe architecture vera software numerical perspectives along goals constraints drove major design decisions implications explain vera environment rather framework toolkit distinctions relevant particularly coupled physics applications provide overview results demonstrate use vera tools variety challenging applications within nuclear industry elsevier inc rights reserved
gene encodes membrane glycoprotein type scavenger receptor present surface many types cells multiple cellular functions ranging angiogenesis gustatory perception fatty acids using case control genetic association approach analyzed selected single nucleotide polymorphisms snp total patients alzheimer disease controls identified allele polymorphism gene significantly increasing risk additionally investigated sample control subjects patients snp apoe gene confirmed previously identified associated snp indeed increased risk decreased age onset reported others earlier based current knowledge biochemistry propose risk imparting variants alter cholesterol homeostasis oxidation stress induce pathological inflammatory cascades snp previously associated heart disease conditions present study first identify significant association variations gene risk alzheimer disease elsevier societe francaise biochimie biologie moleculaire sfbbm rights reserved
despite fact associative memory studies produce large number false memories neuroimaging analyses utilizing paradigm typically focus neural activity mediating successful retrieval current study sought expand prior research examining neural basis true false associative memories though associative false memories substantially different found semantic perceptual false memory paradigms results suggest associative false memories mediated similar neural mechanisms specifically found increased frontal activity likely represents enhanced monitoring evaluation compared needed true memories correct rejections results also indicated true false associative memories mediated neural activity mtl specifically hippocampus finally activity early visual cortex distinguished true false memories lack neural differences hits correct rejections failed support previous findings suggesting activity early visual cortex represents sensory reactivation encoding related processing elsevier inc rights reserved
current study concerns fundamental problems legionnaires disease four decades legionnaires bacteria first identified still low level clinical awareness humans infected inhalation aerosolized water soil contaminated bacteria several control methods available water disinfection biocide ultraviolet light sterilization copper silver ionization ozonation etc thermal treatment completely eliminate legionella killed almost instantly degrees current paper describes legionella disinfection solar concentrator combined heat recovery system reduces heat demand though study made small system hot water per day system enlarged hot water solar collector area results thus valid also larger systems experiments water treatment solar concentrator summarized analyzed temperature exceeds degrees outlet heat exchanger
study focuses integration aids signals effect students process different types graphical representations representational pictures organizational pictures diagrams standardized multiple choice items assessing science achievement based text picture integration theories type pictorial representation hold different cognitive requirements concerning integration processes two representations depending type representation every picture needed answer item correctly students fifth sixth grade work multiple choice items eye movements recorded results showed students achieved higher test scores items presented integrated format non integrated format however true diagrams eye movement data revealed students looked longer graphical representations items presented integrated format condition compared non integrated format condition furthermore relations looking diagrams achievement integrated format emerged authors published elsevier ltd
proteins building blocks cells living creatures kingdoms due pivotal role protein structures understanding evolutionary relationships inferring functions need publically available databank recognized results establishment protein data bank repository protein structures form text files understanding accessing protein structures plain text files cumbersome job little bit difficult understand data well several struggles made transform protein structures protein data bank relational databases available relational databases protein structures till either provide complete information protein structures convenient relational protein databank presented paper repository protein structures protein databank stored tables web interface provided access various elements protein structures much user friendly way structure relational protein database made data selection insertion deletion editing easy rpdb developed mysql open source relational database management system
background recently identified anti inflammatory cytokine previously reported recombinant fusion protein murine human igg fragment ril reduced cytokines vitro however unclear whether attenuate nasal allergic responses symptoms allergic rhinitis vivo methods investigate vivo effect allergic rhinitis mice mice sensitized ovalbumin ova intranasal administration ril intranasal challenge ova performed nasal symptoms estimated last nasal challenge nasal tissue cervical lymph nodes cln collected ova specific ige sera ova specific cell response production cytokines stimulated ova antigen measured transcription level foxp frequency regulatory cells also measured results ril significantly inhibited number sneezes nasal rubbing movements also reduced number eosinophils nasal mucosa significantly decreased level ova specific ige ova specific cell proliferation production furthermore ril significantly increased production transcription level foxp frequency regulatory cells conclusions study showed first time ril inhibits nasal allergic responses symptoms mice ril increases foxp regulatory cells cln study also suggests intranasal administration attenuate allergic rhinitis copyright japanese society allergology production hosting elsevier
present paper proposes semi empirical analytical expression capable determining shear strength reinforced concrete beams longitudinal bars presence reinforcing fibers transverse stirrups expression based evaluation strength contribution beam arch actions makes possible take interaction fibers account strength contribution stirrups effective stress reached beam failure considered introducing effectiveness function function shows share beam action strength contribution global strength beam calculated including effect fibers expression calibrated basis experimental data available literature referring fibrous reinforced concrete beams steel fibers recently obtained authors also include following variables strength previsions geometrical ratio longitudinal bars tension shear span depth ratio strength materials fiber characteristics size effects finally recent analytical expressions capable predicting shear strength fibrous concrete beams also presence stirrups mentioned comparison made experimental data results obtained authors
visual breakout prediction method mold monitoring proposed based temperatures measured thermocouples mold combined use computer vision technology mold temperature rate thermography allows characteristics abnormal temperature regions captured extracted including rate temperature change time geometry propagation velocity basis characteristics back propagation neural network model constructed detect mold breakout weight threshold values model optimized using levenberg marquardt algorithm genetic algorithm iterative process sample training testing results show neural network model better traditional models breakout prediction model higher accuracy rate lower false alarm rate model also compared actual bops used continuous casting production meanwhile provides way detecting abnormalities visually continuous casting process results work also provide positive example application intelligent monitoring visualization methods continuous casting
since increase hepatitis virus infection among hiv infected hiv men sex men observed evidence points blood exposure sex medium hepatitis virus transmission hepatitis virus prevalence among hiv msm overall relation injection drug use poorly characterized study systematic review meta analysis examining global hepatitis virus antibody prevalence estimating active hepatitis virus prevalence among hiv msm conducted reports provided anti hepatitis virus prevalence data among hiv msm pooled prevalence produced overall anti hepatitis virus prevalence among hiv msm active hcv prevalence estimate anti hepatitis virus prevalence among injection drug use non injection drug use hiv msm respectively among hiv msm hepatitis virus prevalence increased significantly time among overall non injection drug use groups decreased significantly among injection drug use hiv msm identified moderate prevalence hepatitis virus among hiv msm among non injection drug use hiv msm prevalence observed increasing slightly pooled prevalence hepatitis virus among hiv msm higher observed birth cohort modest rising hepatitis virus prevalence among hiv msm suggests opportunity control hcv among hiv msm combined data demonstrating rising hepatitis virus incidence highlights temporal urgency
purpose background activating sedating adverse effects antipsychotics obstacles use methods procedures study quantified activating sedating properties first line oral second generation antipsychotics examining rates adverse reactions reported product labeling indications schizophrenia adjunctive treatment major depressive disorder additional data sources included regulatory documents study synopses published study reports attributable risk increase number needed harm nnh calculated agent versus placebo findings results heterogeneity among different antipsychotics regarding activating sedating adverse events observed agents displaying potential activating sedating properties agents indicated treatment schizophrenia predominantly activating medications include lurasidone nnh akathisia somnolence cariprazine nnh akathisia somnolence combined terms similarly activating sedating risperidone nnh akathisia sedation aripiprazole nnh akathisia somnolence predominantly sedating olanzapine quetiapine immediate extended release ziprasidone asenapine iloperidone agents neither activating sedating paliperidone brexpiprazole major depressive disorder overall findings regarding activation sedation appear similar seen schizophrenia data extracted limited available registrational studies contributed adverse event tables contained product labels postregistrational comparative studies may yield different outcomes implications conclusions differences tolerability profiles regarding activation sedation implications terms selecting optimal antipsychotic given individual
gender norms gender role conflict stress may influence hiv risk behaviors among men however scales measuring constructs need development evaluation african settings conducted exploratory confirmatory factor analyses evaluate gender equitable men scale gems gender role conflict stress grc scale among men rural northeast south africa final item gems unidimensional adequate model fit reliability alpha factor loadings low items related violence sexual relationships final item grc scale multidimensional four factors success power competition subordination women restrictive emotionality sexual prowess scale adequate model fit good reliability alpha gems good measure inequitable gender norms new revised scale items may need explored south african context adding grc scale capture men strain related gender roles could provide important insights men risk behaviors
little consensus regarding verticality social power dominance status related accurate interpersonal perception relation could either positive negative could many causal processes play present article discusses theoretical possibilities presents meta analysis question studies using standard test interpersonal accuracy higher socioeconomic status ses predicted higher accuracy defined accurate inference meanings cues also higher experimentally manipulated vertical position predicted higher accuracy defined accurate recall others words addition although personality dominance predict accurate inference overall type personality dominance empathic responsible dominance positive relation egoistic aggressive dominance negative relation accuracy studies involving live interaction higher experimentally manipulated vertical position produced lower accuracy defined accurate inference cues however methodological problems place result doubt
objective determine independent perinatal intrapartum factors associated neonatal hypoglycemia method singleton pregnancies delivered term neonates diagnosed hypoglycemia compared neonate controls regression analysis results regression analysis showed independent prenatal factors multiparity odds ratio gestational age gestational diabetes macrosomia small gestational age neonate sga admission cervical dilation intrapartum factors cesarean section last cervical dilation independently significantly associated neonatal hypoglycemia biologically plausible risk factors independent factors cesarean section gentamycin clindamycin labor gestational age macrosomia mothers babies neonatal hypoglycemia blood loss longer hospital stays neonates hypoglycemia worse umbilical cord gases neonatal hypoxic conditions neonatal morbidities nicu admissions conclusion diabetes protective neonatal hypoglycemia may explained optimum maternal glucose management nevertheless macrosomia independently predictive neonatal hypoglycemia cesarean section decreasing gestational age consistent independent risk factors followed treatment chorioamnionitis sga studies evaluate observations develop preventive strategies warranted
paper presents new current mode implementation balanced output signal generator utilizes operational floating current conveyor ofcc basic building block ofcc current mode device shows flexible properties respect current voltage mode circuits advantages proposed current mode balanced output signal generator cmbg threefold firstly offers accurate phase amplitude performance wide bandwidth without requiring matched resistors secondly differential input provide either current voltage outputs finally proposed cmbg circuit offers significant improvement accuracy compared cmbgs based current conveyor proposed cmbg analyzed simulated experimentally tested experimental results verify proposed cmbg outperforms existing cmbgs terms number basic building blocks used accuracy
robotic manipulators highly coupled nonlinear systems wherein time varying parameters uncertainties adversely affect characteristics response systems hence systems require effective robust controller handle complexities difficult challenge control engineers paper presents two layered fractional order fuzzy logic controller foflc scheme two link planar rigid robotic manipulator payload trajectory tracking task optimal design controller parameters proposed scheme obtained potential meta heuristic technique named cuckoo search algorithm csa order ensure effectiveness performance proposed foflc compared integer order design approach two layered flc flc single layered flc flc conventional proportional integral derivative pid controllers robustness testing carried parameter variations external disturbance rejection elsevier rights reserved
time delay caused calculation time unavoidable implementation digital controller also degrades control performance order cope time delay control single phase uninterruptible power supply ups paper proposes time delay compensator based smith predictor voltage current controller also evaluates usefulness compensator analytic analysis experimental results theoretically compensator alleviates effect time delay voltage current controller compensation fast current control usually sufficient practical point view experimental results presented show validity proposed design analysis time delay compensator single phase ups
one important topics morphometry received high attention recently longitudinal analysis shape variation according kendall definition shape shape object appertains non euclidean space making longitudinal study configuration somehow difficult however simplify task triangulation objects constructing non parametric regression type model unit sphere pursued paper prediction configurations time instances done using properties triangulation size great baselines moreover minimizing euclidean risk function proposed select feasible weights constructing smoother functions non parametric smoothing manner provide proper shape growth models analysis objects varying time proposed models applied analysis two real life datasets
backgroundhealthcare workers occupationally exposed various allergens protective gloves surface instrument disinfectants drugs skin care products increased prevalence sensitization thiurams glutaraldehyde formaldehyde glyoxal nurses occupational contact dermatitis ocd known since objectivesto update range occupational allergens healthcare professionals methodswe retrospectively analysed patch test data information network departments dermatology ivdk patch test results nurses ocd compared nurses without ocd resultssignificantly increased sensitization rates found thiuram mix potassium dichromate methylchloroisothiazolinone methylisothiazolinone colophonium bromo nitropropane diol zinc diethyldithiocarbamate patch testing products patients workplaces gave additional clues allergens example tetrazepam conclusionsthe known range contact sensitization nurses ocd confirmed formaldehyde allergy seems less important today drugs tetrazepam occupational sensitizers nurses increase chromium sensitization remains unexplained
preisach hysteresis model adopted extensively magnetic smart material based systems fidelity model hinges accurate identification preisach density function existing work identification density function usually involves applying input provides sufficient excitation measuring large set output data paper propose novel compressive sensing based approach preisach model identification requires fewer measurements proposed approach adopts discrete cosine transform output data obtain sparse vector order output data assumed known model parameters efficiently reconstructed using proposed scheme comparison purposes constrained least squares scheme using number measurements also considered root mean square error adopted examine model identification performance proposed identification approach shown better performance least squares scheme simulation experiments involving vanadium dioxide integrated microactuator
diabetes mellitus simulated rats gestation day single intraperitoneal injection streptozotocin doses pregnant females showed increased glucose concentrations blood urine embryonic developmental disorders tongue protrusion edema skin hyperemia concomitant vascular damage hemorrhage hematoma well pre post implantation embryo loss afobazole administered orally doses pregnant rats streptozotocin induced diabetes significantly decreased prenatal developmental disorders pre post implantation embryo loss rate afobazole dose produced maximum protective effect rats receiving streptozotocin post implantation embryo loss decreased times afobazole doses significantly reduced blood glucose concentration pregnant rats normalized glycemia day old male offspring
growth differentiation factor gdf also called myostatin member transforming growth factor tgf super family negative regulator skeletal muscle growth gdf also associated bone metabolism however function gdf bone metabolism fully understood study aimed investigate role gdf bone metabolism vitro vivo results showed gdf negative regulatory effect primary mouse osteoblasts promoted receptor activator nuclear factor ligand rankl induced osteoclastogenesis vitro intraperitoneal injection recombinant gdf repressed bone formation accelerated bone resorption mice furthermore treatment aged mice gdf neutralizing antibody stimulated new bone formation prevented bone resorption thus study showed gdf plays significant regulatory role bone formation bone resorption thus providing potential therapeutic pathway osteoporosis
interface management emerging construction management practice industry finds necessary megaprojects become complex global defined appropriate management communications relationships deliverables among stakeholders effective integral project success yet emerging discipline implementation varied widely across industry furthermore effect project performance still unclear address gaps construction industry institute cii chartered research team identify current state investigate relationship systematic project performance accomplish authors conducted structured interviews projects study results showed practices often found industrial projects dollar values one billion addition adoption positively correlated project dollar value number interface stakeholders terms performance projects systematic tend lower mean less dispersed cost growth compared projects without systematic results contribute understanding potential benefits appropriate application develops used practice american society civil engineers
study objective using qualitative method purpose study obtain information directly adolescents attitudes knowledge regarding emergency contraception investigate presence differences male female participants attitudes knowledge design participants study consisted single sex focus groups adolescents male female aged years conducted among high schools regions italy results data analyzed thematic analysis taking account gender differences main themes emerged first labeled adolescents attitudes toward emergency contraception divided subthemes aware life line everything child second theme labeled adolescents knowledge toward emergency contraception divided subthemes false myths baseline information take conclusion italian adolescents believed important prevent risk unprotected sex using contraceptive methods motivation use emergency contraception related critical attitudes toward consequences irresponsible ineffective contraception although adolescents awareness emergency contraception comprehensive knowledge needed findings inform specific interventions aimed educating adolescents need emergency contraception
brassica juncea important oil seed crop throughout world demand cultivation oil seed crops gained importance due rapid increase world population industrialization fungal diseases pose great threat brassica productivity worldwide absence resistance genes fungal infection within crossable germplasms crop necessitates deployment genetic engineering approaches produce transgenic plants resistance fungal infections current study hypocotyls cotyledons brassica juncea used explants transformed agrobacterium tumefacien strain eha harboring binary vector pekb nic containing synthetic chitinase gene nic antifungal gene control cauliflower mosaic virus promoter camvs bar genes npill gene used selectable markers presence chitinase gene trangenic lines confirmed pcr southern blotting analysis effect extracted proteins non transgenic transgenic lines observed growth alternaria brassicicola common disease causing pathogen brassica crop comparison non transgenic control lines leaf tissue extracts transgenic lines showed considerable resistance antifungal activity brassicicola antifungal activity transgenic lines observed corresponding transgene copy number
structural brain abnormalities amply demonstrated schizophrenia include volume decrements perirhinal entorhinal regions ventromedial temporal lobe comprise primary olfactory cortex olfactory impairments hallmark schizophrenia precede onset illness distinguish adolescents experiencing prodromal symptoms healthy youths may predict transition prodrome frank psychosis therefore examined temporal lobe regional volumes large adolescent sample determine structural deficits ventromedial temporal lobe areas associated schizophrenia also heightened risk psychosis seven temporal lobe regional volumes amygdala hippocampus inferior temporal gyrus parahippocampal gyrus superior temporal gyrus temporal pole entorhinal cortex measured psychosis spectrum adolescents adolescents types psychopathology healthy adolescents philadelphia neurodevelopment cohort total intracranial left volumes smallest among psychosis spectrum measures distinguished groups left also smaller psychosis spectrum compared healthy subjects volume decrement strongly correlated impaired cognition less robustly associated heightened negative disorganized symptoms volume decrement correlated positive symptoms persecution special abilities temporal lobe volumes classified psychosis spectrum youths high specificity relatively low sensitivity mri measures may therefore serve important confirmatory biomarkers denoting worrisome preclinical trajectory among risk youths specific pattern deficits may predict specific symptom profiles
retinae patients multiple sclerosis part central nervous system cns display inflammatory neurodegenerative changes increasing evidence suggesting retinal changes particular neurodegeneration mirror global cns alterations spectral domain optical coherence tomography oct inexpensive rapid non invasive reproducible imaging technique generates highresolution images tissues retina advantage oct magnetic resonance imaging techniques assessment neurodegeneration may sensitivity capture changes individual patient level several studies demonstrate changes within inner retina primarily reflection optic neuropathy assessed oct correlate reduced quality life visual dysfunction global disability moreover longitudinal studies suggest inner retinal thinning early phenomenon retinal thinning may occur independent previous symptomatic episodes optic neuritis significantly correlating inflammatory disease preliminary studies suggest disease modifying therapies may differential effects octdetermined rates retinal atrophy supporting potential utility oct investigate
recently lot effort made ground rorschach interpretations evidence base date however studies yet described via fmri brain areas get involved one takes rorschach fill gap literature administered ten inkblot stimuli healthy volunteers fmri analysis bold signals revealed compared fixating cross looking rorschach inkblots thinking might associated higher temporo occipital fronto parietal activations greater activity small sub cortical regions included limbic system findings line traditional conceptualization test suggest taking rorschach involves high level visual processing top well bottom attentional processes perception processing emotions emotional memories
image processing rapid approximate solution variational problems involving generic data fitting terms often practical relevance example real time applications variational solvers based diffusion schemes euler lagrange equations slow restricted types data fitting terms present filter based approach reduce variational energies contain generic data fitting terms restricted specific regularizations approach based reducing regularization part variational energy guaranteeing non increasing total energy applicable regularization dominated models data fitting energy initially increases regularization energy initially decreases present fast discrete filters regularizers based gaussian curvature mean curvature total variation pixel local filters used rapidly reduce energy full model prove convergence resulting iterative scheme greedy sense show several experiments demonstrate applications image processing problems involving regularization dominated variational models
background services treat tobacco dependence readily available smokers low middle income countries lmics smoking prevalence remains high conducting cluster randomized controlled trial comparing effectiveness two strategies implementing tobacco use treatment guidelines community health centers chcs viet nam guided consolidated framework implementation research cfir prior implementing trial conducted formative research identify factors may influence guideline implementation inform modifications intervention may necessary translate model care delivery high income country hic local context lmic methods conducted semi structured qualitative interviews chc medical directors health care providers village health workers vhws eight chcs interviews transcribed verbatim translated english two qualitative researchers used deductive cfir theory driven inductive open coding approaches analysis developed codes themes relevant aims study results interviews explored four five cfir domains intervention characteristics outer setting inner setting individual characteristics relevant analysis potential facilitators intervention included relative advantage intervention compared current practice intervention characteristics awareness burden tobacco use population outer setting tension change due lack training need skill building leadership engagement inner setting strong sense collective efficacy provide tobacco cessation services individual characteristics potential barriers included perception intervention complex intervention characteristic necessarily compatible inner setting current workflows staffing historically designed address infectious disease prevention control rather chronic disease prevention competing priorities determined moh outer setting conclusions study cfir provided valuable framework evaluating factors may influence implementation systems level intervention tobacco control lmic understand adaptations may needed translate model care delivery hic lmic
multi study analysis fmri studies participants explores functional activation connectivity cerebellum cerebrum repeated behavioral information uptake informing personality traits different persons results suggest trait repetition recruits activity areas belonging mentalizing executive control networks cerebrum executive control areas cerebellum cerebral activation observed executive control network including posterior medial frontal cortex pmfc bilateral prefrontal cortex pfc bilateral inferior parietal cortex ipc mentalizing network including bilateral middle temporal cortex mtc extending right superior temporal cortex stc well visual network including left cuneus cun left inferior occipital cortex moreover cerebellar activation found bilaterally lobules vii belonging executive control network importantly significant patterns functional connectivity found linking cerebellar executive areas cerebral executive areas medial pmfc left pfc left ipc mentalizing areas left mtc addition connectivity found cerebral areas left hemisphere involved executive mentalizing networks well homolog areas right hemisphere discussion centers role cerebello cerebral connections matching internal predictions generated cerebellum external information cerebrum presumably involving sequencing behaviors elsevier inc rights reserved
gaussian process models provide flexible nonparametric approach modeling location time indexed datasets however storage computational requirements models infeasible large spatial datasets nearest neighbor gaussian processes datta banerjee finley gelfand hierarchical nearest neighbor gaussian process models large geostatistical datasets stat assoc jasa provide scalable alternative using local information nearest neighbors scalability achieved using neighbor sets conditional specification model show equivalent sparse modeling cholesky factors large covariance matrices also discuss general approach construct scalable gaussian processes using sparse local kriging present multivariate data analysis demonstrates nearest neighbor approach yields inference indistinguishable full rank despite several times faster finally also propose variant nngp model automating selection neighbor set size wiley periodicals inc
geopolymers novel binding materials produced alkaline activation rich aluminosilicate materials geopolymer binders considered green building materials increasing potential replace ordinary portland cement concrete industry study investigated alkali solution effects physical mechanical properties high calcium fly ash based geopolymers parameters involved study naoh solution molarity nasio naoh ratio three naoh concentrations molars investigated nasio naoh ratio varied results showed studied parameters significantly affected properties produced geopolymer mortars workability setting time found decrease increasing naoh concentration increasing nasio naoh ratio influence naoh concentration higher workability setting time nasio naoh ratio highly affected compressive strength initial setting time range minutes final setting occurred quickly within minutes oven curing method resulted high strength early ages mixes able achieve days strength within first days days compressive strength ranged mpa promotes use high calcium fly ash production early high strength geopolymer concrete authors published elsevier ltd
rationale primary bone lymphoma pbl rare malignant entity better survival pbl malignant bone tumors extranodal lymphomas patient concerns report rare case pbl involving radius tibia patient year old girl left forearm pain swelling trauma six months later last chemotherapy radiotherapy pain swelling left knee presented diagnoses radiological imaging revealed lytic destruction periosteal reaction pathological fracture radius tibia soft tissue mass surgical biopsy performed result histopathological diagnosis diffused large cell lymphoma stage group intervention chemotherapy combined radiotherapy applied curation lessons due uncommon presentation pbl taken consideration differential diagnosis bone tumors necessary clinic
background functional decline among patients mental illness unique individuals psychotic disorders despite research early predictors functional outcome mainly focused individuals thought risk mental state arms psychosis evidence suggesting certain early vulnerability markers neurological soft signs nss may explain variability functional outcomes independent level psychosis risk traditional diagnostic classification method structural equation modeling applied baseline data prospective longitudinal study young individuals treatment secondary services non psychotic disorders evaluated theoretically based models pathways functional outcome starting nss intervening variables established according previous evidence drawn two general categories cognition neuro social negative symptoms expressive experiential results final trimmed model single path running nss neurocognition experiential negative symptoms outcome could improved adding dropping connections would change single path multiple paths indirect effect nss outcome significant validity model independent arms status psychiatric diagnosis conclusions results provide evidence single pathway model starting intervening variables represent modifiable trans diagnostic therapeutic targets improve functional trajectories young individuals recent onset psychiatric diagnosis different levels psychosis risk
phase measuring profilometry pmp widely used many fields like computer aided verification cav flexible manufacturing system fms high frame rate hfr real time vision based feedback control common demands near future however instruction time delay computer caused numerous repetitive operations greatly limit efficiency data processing fpga advantages pipeline architecture parallel execution fit handling pmp algorithm paper design fully pipelined hardware architecture pmp functions hardware architecture includes rectification phase calculation phase shifting stereo matching experiment verified performance method factors may influence computation accuracy analyzed
design performance analyses geosynthetic reinforced soil structures repeated loading induced compaction traffic earthquakes understanding cyclic soil geosynthetic interface behaviour great interest nevertheless experimental data concerning type behaviour scarce laboratory study carried described paper paper presents behaviour interface silica sand high strength geotextile monotonic cyclic loading conditions large scale direct shear test device able perform load displacement controlled cyclic tests used results obtained presented discussed especially terms interface shear stiffness damping ratio monotonic direct shear tests indicated coefficients interaction sand geotextile interface depend confining pressure cyclic direct shear tests indicated interface stiffness tends increase first loading cycles exhibiting slight variation cycles slightly higher values shear stiffness damping ratio reached displacement controlled cyclic direct shear tests cyclic loading interface lead degradation post cyclic peak shear strength however post cyclic shear strength large displacements exhibited important decrease
objective carried systematic review meta analysis evaluate whether history bipolar disorder increases risk dementia methods searched pubmed scopus identify studies evaluated risk dementia individuals history total studies including individuals history non individuals included meta analysis results history significantly increased risk diagnosis dementia pooled odds ratio confidence interval evidence heterogeneity publication bias analysis found conclusion history associated significantly higher risk dementia older adults future studies necessary evaluate potential mediators association evaluate interventions may reduce risk dementia population
region model analysis important method analyzing interior fire hazard based mass conservation equation energy conservation equation pre flashover interior fire hazard development formulae required computer programming derived utilized tool developing computation program aid object programming idea apply mathematical modelling theories release rate fire heat plume heat transfer relevant programming procedures computation flow chart presented program verified experimental data tianjin fire research institute computation plumes oversimplified thickness change smoke layer results obtained experiment vary considerably main advantage proposed computation model ease utilized variety occasions
paper considers novel approach system identification allows accurate models created linear nonlinear multi input output systems addition conventional system identification applications method also used black box tool model order reduction nonlinear kalman filter extended include slow varying parameter states canonical model structure interestingly spite model parameters unknown start filter able evolve parameter estimates achieve accuracy noise free test cases also proven robust noise measurements canonical structure ensures well conditioned model simultaneously provides valuable dynamic information engineer extensive testing linear example model structure extended generalised nonlinear form shown accurately identify handling response full vehicle model
paper deals building managing corporate reputation star hotels athens attica well role leadership corporate reputation primary research hotel firms athens attica helped identify extent charismatic leadership skills leader positively affect reputation hotels extent charismatic leadership related leader skills statistical analysis research results revealed one hand number positive correlations factors variables examined hand particularly strong correlations sub factors thus allowing reaching conclusions making suggestions research
meaning life found protective factor suicidal ideation aim study investigate whether meaning life moderate buffer association suicide risk factors hopelessness women borderline personality disorders one hundred twenty four women diagnosed borderline personality disorder completed self report measures suicide risk factors hopelessness meaning life main result study meaning life moderated association suicide risk factors hopelessness meaning life important variable prevention treatment risk suicide women borderline personality disorder
data driven low order modelling enjoying rapid advances fluid mechanics arguably sirovich appl maths vol xlv started developments snapshot proper orthogonal decomposition particularly simple method resulting reduced order models provide valuable insights flow physics allow inexpensive explorations dynamics operating conditions enable model based control design winning argument proper orthogonal decomposition pod optimality property guarantee least residual given number modes price unpleasant frequency mixing modes complicates physical interpretation contrast temporal fourier modes dynamic mode decomposition dmd provide pure frequency dynamics lose orthonormality optimality property pod sieber fluid mech vol bridge least residual pure frequency behaviour ingenious interpolation called spectral proper orthogonal decomposition spod article puts achievement berlin authors perspective illustrating potential spod challenges ahead
bluetooth low energy beacons gained traction among ambient intelligence researchers low cost robustness make fit choice ambient assisted living healthcare applications nevertheless similar many radio frequency based technologies beacons pose serious challenges comes developing applications require predictability moreover multipath propagation characteristics bluetooth beacons prevent ambient intelligent researchers solely rely using theoretical models describe behaviors paper present empirical evaluation bluetooth beacons behaviors describe observed pattern signal series experiments totalizing million samples
article miniaturized ultrathin absorptive transmissive radome wideband absorbing property designed thickness designed radome effectiveness verified synthetic experiments measurement anechoic chamber furthermore oblique incidents also evaluated transmission coefficients reflection coefficients wiley periodicals inc
paper describe novel approach obtain automatic adaptation robot body schema improve robot perceptual motor skills based body knowledge predictions obtained mental simulation body combined real sensory feedback achieve two objectives simultaneously body schema adaptation markerless hand pose estimation body schema consists computer graphics simulation robot includes arm head kinematics adapted online movements appearance model hand shape texture mental simulation process generates predictions hand appear robot camera images based body schema proprioceptive information motor encoders predictions compared actual images using sequential monte carlo techniques feed particle based bayesian estimation method estimate parameters body schema updated body schema improve estimates hand pose used closed loop control scheme visual servoing enabling precise reaching report experiments icub humanoid robot support validity approach number simulations precise ground truth performed evaluate estimation capabilities proposed framework show use high performance gpu programing edge based algorithm visual perception allow real time implementation real world scenarios
early life stress rodents associated increased amygdala volume adulthood humans amygdala develops rapidly first two years life thus disturbed care period may particularly important amygdala development context year longitudinal study impoverished highly stressed families assessed whether disorganization attachment relationship infancy related amygdala volume adulthood amygdala volumes assessed among low income young adults years first observed infancy months followed longitudinally age infancy mos disorganized infant attachment behavior disrupted maternal communication assessed standard strange situation procedure ssp increased left amygdala volume adulthood associated maternal infant components disorganized attachment interactions months age overall later stressors including childhood maltreatment attachment disturbance adolescence significantly related left amygdala volume left amygdala volume associated dissociation limbic irritability adulthood finally left amygdala volume mediated prediction attachment disturbance infancy limbic irritability adulthood results point likely importance quality early care amygdala development human children well rodents long term prediction found suggests first two years life may early sensitive period amygdala development clinical intervention could particularly important consequences later child outcomes elsevier rights reserved
red blood cells play key role normal hemostasis thrombosis ability affect coagulation multifactorial depends mechanical properties affecting viscosity blood flow ability aggregate adhere potentially vascular endothelium molecular signaling via microvesicles surface proteins including blood group antigens participation nitric oxide metabolism transfused red blood cells suffer storage lesion damages cells leading changes shape function intracellular communication article review transfused red blood cells may lead increased hemorrhage increased thrombosis
recent interest impact emotional expressions computers people decision making however despite growing body empirical work mechanism underlying effects still clearly understood address issue paper explores two kinds processes studied emotion theorists human human interaction inferential processes whereby people retrieve information emotion expressions beliefs desires intentions affective processes whereby emotion expressions evoke emotions others influence decisions tease apart two processes occur human computer interaction looked physiological measures electrodermal activity heart rate deceleration present two experiments participants engaged social dilemmas embodied agents expressed emotion results show first people decisions influenced affective cognitive processes according prevailing process people behaved differently formed contrasting subjective ratings agents second show individual trait known electrodermal lability measures people physiological sensitivity predicted extent affective inferential processes dominated interaction discuss implications design embodied agents decision making systems use emotion expression enhance interaction humans computers elsevier ltd rights reserved
digital low dropout regulator ldo drawn significant attention recently low voltage operation process scalability however ldo inherently suffers limit cycle oscillation lco address issue modes amplitudes lco calculated work verified spice simulation cmos process lco reduction technique ldo proposed adding two unit power transistors parallel main power mos array feedforward path technique sets lco mode effectively reduces ripple amplitude wide load current range compared dead zone scheme technique minimizes lco negligible circuit complexity design difficulty
standard medicare part benefit structure copayments medications change discontinuously certain levels accumulative drug spending beneficiaries pay cost medications initial phase coverage gap catastrophic phase examine whether individuals anticipate copayment changes adjust consumption advance use variation birth months beneficiaries enroll part plans first turn birth months generate exogenous variation end year price enroll earlier year likely reach coverage gap enroll later study impact variation end year price first three months medication use immediately following enrollment use difference differences adjust seasonal trends use comparing main study group receive low income subsidies therefore face coverage gap find strong evidence anticipatory behavior implied elasticity respect future prices ranging addition find beneficiaries modify consumption changing quantity prescriptions filled instead switching brand name generic drugs copyright john wiley sons ltd
several researchers around world studied gesture recognition recent techniques fall curse dimensionality useful real time environment study proposes system dynamic gesture recognition prediction using innovative feature extraction technique called convexity approach proposed method generates smaller feature vector describe hand shape minimal amount data dynamic gesture recognition prediction system implements two independent modules based hidden markov models dynamic time warping two experiments one gesture recognition another prediction executed two different datasets rppdi dynamic gestures dataset cambridge hand data results showed discussed elsevier inc rights reserved
objectiveto examine social environmental factors affect moderate vigorous physical activity mvpa mid adolescent hispanic females design samplesecondary data analysis examine social environmental level factors related mvpa levels mid adolescent hispanic females measuresdata retrieved national survey children health logistic regression used estimate associations factors mvpa resultssignificant mid adolescent predictors english speaking parental attendance activities peer support supportive neighborhood safe school environment conclusionfindings highlight need development age culturally appropriate interventions aid improvement participation levels mvpa among latina adolescent population additionally findings suggest recommendations policy future research
design analysis smart system behavior needs bridge worlds regard engineering methods technologies central adaptivity thus core functionality smart systems systems illustrate domain smart buildings technologies like rule based probabilistic reasoning set strategies define building adaptive behavior control loops firmly set control engineering implement however observe apparent disconnect approaches using demand response change consumption patterns response global demand example illustrate consequences mono disciplinary thinking academic researchers engineering practitioners prone specifically show adaptive behavior couples previously independent dynamics reacting dynamics may lead emerging unintended system state changes non acceptable performance argue stringent links system design analysis based probabilistics simulation adaptivity cyber physical systems needs best control engineering
host associated microbiomes perform many beneficial functions including resisting pathogens training immune system show amphibians developing captivity lose substantial skin bacterial diversity primarily due reduced ongoing input environmental sources combined studies wild captive amphibians database strains allows examine antifungal function skin microbiome tracked skin bacterial communities endangered boreal toads anaxyrus boreas across time points four probiotic treatments two exposures lethal fungal pathogen batrachochytrium dendrobatidis captivity compared samples collected wild populations life stage amphibians captivity lost inhibitory bacteria time proportion individuals exposed became infected rose subsequent exposures inoculations inhibitory probiotic janthinobacterium lividum resulted increase survival second challenge indicating effect microbiome depletion reversible restoring inhibitory bacteria taken together study highlights functional role ongoing environmental inputs skin associated bacteria mitigating devastating amphibian pathogen long term captivity decreases defensive function
osteoporosis common metabolic bone disease experimental study patients experimental control women aged years old registered health centers fasa city fars province iran selected intervention experimental group showed significant increase health belief model constructs self regulation social support nutrition walking performance compared control group months intervention value lumbar spine hip bone mineral density score experimental group increased control group reduced study showed effectiveness health belief model structures self regulation social support prevention osteoporosis women
establishing lives canada international migrants dependent children regularly encounter dramatically different conditions family life parents employment situation limited availability extended kin help child rearing multicultural relatively permissive social environment invite even demand changes newcomers family practices yet information needed ways skilled immigrants negotiate changed conditions work family life country impact family dynamics settlement drawing data interviews skilled immigrants living calgary alberta paper explores coming canada impacted participants situations paid work parenting practices familial gender relations findings suggest strained economic social resources often limited extent mothers fathers able maintain organization family life similar established country origin however cases shifts family formation caused heightened levels stress strain entrenched conventional gender roles others changed conditions acted catalyst positive change tools eased burdens settlement explored recommendations made better support newcomer families
recently number smart material investigated widely used civil construction industries present study investigates application smart semi active piezoelectric friction damper pfd made piezoelectric material seismic control horizontally curved bridge isolated lead rubber bearing lrb main aim study investigate effectiveness hybrid system find optimum parameters pfd seismic control curved bridge selected curved bridge continuous three span concrete box girder supported pier rigid abutment pfd located deck abutments piers chord radial directions bridge excited four different earthquake ground motions three components two horizontal vertical different characteristics observed use semi active pfd lrb quite effective controlling response curved bridge compared passive system incorporation smart damper requiring small amount energy addition isolation system used effective control curved bridge dynamic loading
although things internet things contain considerable amounts software developers software standardized means maintaining improving sharing software applications smart phone limitation hamper user driven innovation paper evaluate usefulness app store metaphor means sharing deploying internet things software among makers set interviews questionnaire based survey sample makers various maker communities used data extract requirements application store using common app store metaphor starting point app store concept developed proof concept implementation evaluated feasibility evaluation focus group evaluation methods findings show although app store metaphor familiar easy grasp fundamental challenges adapting metaphor difficulty supporting diversity software hardware vendor market tension context awareness need pre configuration pre packaging usability challenges related number devices apps
paper investigate traveling wave solutions nonlinear dispersive equation korteweg vries zakharov kuznetsov kdv equation complex coupled kdv system using extended simplest equation method derive hyperbolic function solutions include soliton solutions trigonometric function solutions include periodic solutions special values double parameters rational solutions properties solutions shown figures results show method effective powerful tool handling solutions nonlinear partial differential equations nlees mathematical physics
background despite several polysomnographic studies periodic leg movements plm healthy sleep data prevalence characteristics periodic arm movements pam normal subjects lacking aimed investigate pam association plm wakefulness sleep healthy subjects methods ninety one participants underwent video polysomnography according american academy sleep medicine criteria addition standard electromyographic registration data flexor digitorum superficialis muscles recorded results sixty two subjects pam index wakefulness median pam index wakefulness range seven subjects pam index sleep median pam index sleep range cases pam wakefulness coincident plm wakefulness sleep coincidence evident correlation pam plm weak moderate wakefulness spearman rho sleep spearman rho conclusion healthy subjects pam occur predominantly wakefulness apparent true periodicity contrast classical plm pam may present true periodic phenomenon rather random voluntary movements meeting wide range periodicity criteria plm authors published elsevier
basic model processing packets routing one hardware system another extended describe virtual packet transmission one module another within single program image representing virtual physical ports interchangeably embodying routing relations runtime data structures makes possible produce object modules deployed variety roles without recompilation describe fielded system combines application virtual ports software tool specifying packet routing virtual physical ports advanced linker encapsulates routing actions runtime tables within single multi application image table driven dispatcher effects control flow packet routing present results show performance advantages demonstrate usability security benefits reconfiguring redeploying programs object module form
distribution water pollution often assessed remote sensing study develop fuzzy multiple regression model analyze water quality using data collected advanced visible near infrared radiometer type avnir advanced land observing satellite different time points conduct fuzzy multiple regression analysis avnir data direct measurements local water quality lake hachiroko japan relationship avnir water quality data analyzed solving min max problems compare estimated water quality maps actual distributions study area determine proposed method enables derive water quality conditions effectively avnir data furthermore comparing maps created using avnir data collected different times obtain results revealing temporal changes water quality addition compare maps created using fuzzy multiple regression fuzzy regression models demonstrate former offers greater number solutions provides details water quality
intensive parenting debates reflect critical importance child early years parents roles determining later developmental outcomes mothers usually assigned primary responsibility facilitating infants cognitive development adequate appropriate sensory stimulation drawing foucault technologies self article explores new mothers shape mothering practices order provide appropriately stimulating interactions using findings interviews women interviewed twice women interviewed three main positions identified mothers function relation infants development mother committed facilitator creative provider careful caring monitor study considers perceived normative nature positions impact middle class women subjectivities new mothers analysis parental agendas infant cognitive development suggests continued focus mother role within early infant development reflects upholds ideologies child centred intensive mothering risks precluding alternative maternal subjectivities promotes conservative feminine identities
work studied degradation insecticide fipronil fip heterogeneous photo catalysis induced tio using chemometric methods factorial design response surface methodology possible evaluate role interaction reaction medium reaction time concentration tio optimizing conditions degradation using artificial radiation optimized conditions tio min reaction time fip natural irradiated suspension fip degradation achieved degradation rate terms accumulated uva radiation corresponding pseudo first order rate constant min half life min conditions assays extended use solar radiation degradation rate higher half life min suggesting cases fip degradation successful four products fip photocatalytic degradation could separated identified formation consumption followed uhplc tof although intermediates obtained using irradiation sources faster degradation transformation products tps observed solar irradiation due expressive photonic flux covering uva uvb noteworthy untreated effluent identified compounds low toxicity respect fischeri suggesting heterogeneous photocatalysis may good alternative treatment wastewaters containing fip tps mainly solar radiation source radiation since condition power consumption treatment significantly reduced elsevier ltd rights reserved
university california berkeley ucb performing thermal hydraulics safety analysis develop technical basis design licensing fluoride salt cooled high temperature reactors fhrs fhr designs investigated ucb use natural circulation emergency passive decay heat removal normal decay heat removal systems fail fhr advanced natural circulation analysis fancy code developed assessment passive decay heat removal capability safety analysis innovative system designs fancy code uses one dimensional semi implicit scheme solve pressure linked mass momentum energy conservation equations graph theory used automatically generate staggered mesh complicated pipe network systems heat structure models implemented three types boundary conditions dirichlet neumann robin boundary conditions heat structures composed several layers different materials used simulation heat structure temperature distribution heat transfer rate control models used simulate sequences events trips safety systems proportional integral controller also used automatically make thermal hydraulic systems reach desired steady state conditions point kinetics model used model reactor kinetics behavior temperature reactivity feedback underlying large sparse linear systems models efficiently solved using direct iterative solvers provided superlu code high performance machines input interfaces designed increase flexibility simulation complicated thermal hydraulic systems paper mainly focuses methodology used develop fancy code safety analysis mark pebble bed fhr development ucb performed elsevier ltd rights reserved
capacitive sensors touch proximity varieties becoming common many industrial research applications sensor requires one electrodes create electric field measure changes thereof design layout electrodes crucial designing applications systems influence range detectable objects refresh rate last years new measurement systems materials well advances rapid prototyping technologies vastly increased potential range applications using flexible capacitive sensors paper contributes extensive set capacitive sensing measurements different electrode materials layouts two measurement modes self capacitance mutual capacitance evaluation measurement results reveals well suited certain materials different applications evaluate characteristics materials capacitive sensing enable application designers choose appropriate material application
objective review pharmacology efficacy safety venetoclax treatment lymphoid malignancies data sources literature search performed pubmed medline databases september abstracts american society hematology american society clinical oncology ongoing studies clinicaltrials gov searches performed utilizing following key terms venetoclax abt gdc obatoclax bcl inhibitor navitoclax abt venclexta study selection data extraction studies pharmacology pharmacokinetics pharmacodynamics clinical efficacy safety venetoclax lymphoid malignancies identified data synthesis recently treatment cell lymphoproliferative disorders shifted conventional cytotoxic chemotherapy novel small molecule inhibitors advent recently food drug administration approved oral agents ibrutinib idelalisib shifted paradigm chronic lymphocytic leukemia cll treatment however complete remission uncommon outcome patients progressing treatments remains poor attention focused novel target cell lymphoma protein bcl serves essential role regulation apoptosis venetoclax demonstrated efficacy multiple subtypes lymphoid malignancies including patients relapsed refractory cll harboring deletion overall response rate nearly venetoclax generally well tolerated significant adverse effect tumor lysis syndrome formal management recommendations conclusion venetoclax demonstrated promising results relapsed refractory lymphoid malignancies acceptable adverse effect profile role bcl inhibition various malignancies becomes elucidated venetoclax may offer benefit myriad patient populations
revisit interactive model based approach global optimization proposed wang garcia glob optim parallel threads independently execute model based search method periodically interact simple acceptance rejection rule aimed preventing duplication search efforts paper assumed thread successfully identifies locally optimal solution every time acceptance rejection rule implemented stylized model computational time rate convergence globally optimal solution shown increase exponentially number threads practice however computational time required identify locally optimal solution varies greatly therefore acceptance rejection rule implemented several threads may fail identify locally optimal solution situation calls reallocation computational resources order speed identification local optima one threads repeatedly fail paper consider implementation interactive model based approach accounts real time takes account possibility several threads may fail identify locally optimal solution whenever acceptance rejection rule implemented propose modified acceptance rejection rule alternates enforcing diverse search order prevent duplication reallocation computational effort order speed identification local optima show rate convergence real time increases number threads result formalizes idea parallel computing exploitation exploration complementary provided relatively simple rules interaction implemented report results extensive numerical experiments illustrate theoretical analysis performance
traditionally reduction structure diagrams complex control systems realized partitioning three basic types serial parallel feedback connections method always difficult fallible practice often one move positions nodes thus change meaning state variables paper general matrix model linear systems deduced according method computing model directly comes original structure diagram aid computing software problem solved quickly precisely
high therapeutic dosage requirements desire ease administration drive trend subcutaneous administration using delivery systems subcutaneous pumps prefilled syringes dosage volume limits prefilled syringe administration requires higher concentration liquid formulations limited roughly mab ultrafiltration processes routinely used formulate biological therapeutics article considers pressure constraints process may limit ability achieve high final product concentrations system hardware analysis shows ultrafiltration cassette pressure drop major factor limiting systems additional system design recommendations also provided design performance new cassette lower feed channel flow resistance described along modeling feed channel pressure drop implications variations cassette flow channel resistance scaling setting specifications considered recommendation maximum pressure specification provided review viscosity data theory shows molecular engineering temperature use viscosity modifying excipients including adjustment used achieve higher concentrations combined use low pressure drop cassette excipients increased final concentrations guidance provided system operation control hydraulics final concentration recommendations allow one design operate systems routinely achieve target final viscosity capable delivery using pre filled syringe american institute chemical engineers biotechnol prog
paper propose new implementation multi tenant database system combines relational model tree structured storage hierarchical database system order improve efficiency lower storage cost translation layer also designed middleware serve linkage high level logic view low level physical view dbms meanwhile system maintains characteristics functionality multi tenant database system thus proves powerful tool cloud storage dominant background
background psoriasis chronic immune mediated disease affects world population ultraviolet uvb phototherapy effective treatment psoriasis compared systemic treatments currently lack easily accessible online patient educational material regarding form treatment objective present freely available online guide video uvb treatment informative patients increases success compliance patients starting therapy methods uvb treatment protocol used university california san francisco psoriasis skin treatment center well available information literature reviewed design comprehensive guide patients receiving uvb treatment results created printable guide video resource reviews fundamentals uvlight uvb safety considerations flow treatment side effects post phototherapy skin care conclusion guide serves valuable resource patients preparing uvb phototherapy clinicians treat trainees wishing learn form therapy
comparative study performed investigate behavior dredged fills rigid model flexible model containers study focused sedimentation soil fills development total stresses model made acrylic cylinder model two scale size geotextile tube results indicate rigid containers significant decrease sediment height apparent dewatering process hand geotextile permeable water gradually dissipated filling process flexible containers hence significant loss tube height apparent duration test pressure spikes apparent rigid containers filling process attributed confining effect due hydrostatic pressure flexible containers pressure readings gradually increases time filling process normalize end filling stage pressure spikes apparent due gradual dissipation pore water pressure
background pleuroparenchymal fibroelastosis ppfe rare interstitial pneumonia upper lobe predominance fibroelastosis although definite diagnosis requires surgical lung biopsy slb slb often difficult complications refractory pneumothorax objective evaluate urinary desmosines degradation product mature elastin novel biomarker patients ppfe methods biopsy proven patients ppfe prospectively enrolled levels urinary desmosines patients ppfe measured liquid chromatography tandem mass spectrometry compared patients idiopathic pulmonary fibrosis ipf patients chronic obstructive pulmonary disease copd controls results levels urinary desmosines significantly higher patients ppfe patients ipf creatinine patients copd creatinine controls creatinine desmosines discriminated ppfe ipf area curve auc ppfe controls auc however levels desmosines correlated physiological parameters patients ppfe conclusions urinary desmosines may useful diagnostic biomarker patients ppfe measurement desmosines combined specific clinical radiological features ppfe may lead accurate diagnosis without slb patients ppfe elsevier ltd rights reserved
paper nanostructured biosensor developed detect glucose tear using fluorescence resonance energy transfer fret quenching mechanism designed fret pair including donor cdse zns quantum dots qds acceptor dextran binding malachite green dextran conjugated concanavalin con enzyme specific affinity glucose presence glucose quenched emission qds fret mechanism restored displacing dextran con dual modulation sensor convenient accurate detection nanostructured fret sensors assembled onto patterned zno nanorod array deposited synthetic silicone hydrogel consequently concentration glucose detected patterned sensor converted fluorescence spectra high signal noise ratio calibrated image pixel value photoluminescence intensity patterned fret sensor increases linearly increasing concentration glucose mmol mmol covers range tear glucose levels diabetics healthy subjects meanwhile calibrated values pixel intensities fluorescence images captured handhold fluorescence microscope increases increasing glucose four male sprague dawley rats different blood glucose concentrations utilized demonstrate quick response patterned fret sensor tear samples
cloud computing environment expanded considerably rapid advancement related technologies although cloud computing convenient users detecting preventing possible security breaches remains unsolved problem security logs critical data indicate events operating system software data stored heterogeneous machines network security devices server systems database management systems dbms however existing methods create problems efficient analysis large scale heterogeneous security logs cloud computing environment therefore cloud computing provides various services users efficient integration method security logs must developed study proposes nosql based method collect integrate security logs using mapreduce study shows log data reduced integrating duplicate large scale security logs proposed method provides faster data storage conventional dbms effective
combining technical tactical game components appropriate physical loading modified games provide ideal environment young athletes develop aerobic fitness time accumulate precious hours technical skills development furthermore modified games provide opportunity players develop decision making problem solving skills stressful physical loads critical factors successful long term player development article discusses constraints believed important optimizing aerobic fitness skill acquisition youth using modified games approach video abstract describing issue see video supplemental digital content http links lww com scj
due large magnetic relevant air gap leakage inductance main inductance surface mounted permanent magnet machine major components leakage inductance known harmonic leakage slot leakage inductance paper proposes analytical method determine two leakage components fractional slot concentrated winding machine fscw arbitrary phase number comparison machine design distributed winding dtbw number poles fundamental flux linkage done comparison done fscw machines double layer single layer winding layout
objectives describe haemagglutinin neuraminidase sequencing apparent cross site influenza outbreak renal transplant haemodialysis patients confirmed whole genome sequencing wgs methods isolates sequenced influenza positive individuals phylogenetic trees constructed using sequencing subsequently wgs sequence data analysed determine genetic relatedness viruses obtained inpatient outpatient cohorts compared epidemiological outbreak information results patient cases influenza inpatient renal ward cohort associated deaths patient cases outpatient haemodialysis unit cohort deaths wgs confirmed clustered transmission two genetically different influenza pdm strains initially identified analysis genes wgs took longer case required determine whether two seemingly linked outbreaks related conclusion rapid sequencing genes may sufficient aid early influenza outbreak investigation making appealing future outbreak investigation however next generation sequencing becomes cheaper widely available bioinformatics software freely accessible next generation whole genome analysis may increasingly become valuable tool real time influenza outbreak investigation crown copyright published elsevier ltd behalf british infection association rights reserved
work result study struggles achievements lgbt community brazil historical context religious context see initially discriminatory process arising conflict human society live conflict may create social transformation two main issues addressed within historical trajectory homosexuality prevailing juxtaposition normal pathological since antiquity characterized today dichotomized presentation perversion along side political debate social acceptance achievement citizenship recognition basic civil rights exercise religious issues fueled condemning rhetoric regarding practice homosexuality intolerance relationship homosexuals homosexuality emergence diseases aids become open dialogue although without promoting tolerance brotherhood lgbt religious communities said discourse even though stereotypes constituted tend last centuries due large strides favor lgbt community experiencing quick break paradigms issues founded monograph remains grounded literary research brought clarification issue prompting new studies exploring theme
many existing techniques reversing data structures binaries limited low level programming constructs individual variables structs unfortunately without detailed information program pointer structures forensics reverse engineering exceedingly hard fill gap propose mempick tool detects classifies high level data structures used stripped binaries analyzing links memory objects evolve throughout program execution distinguishes many commonly used data structures singly doubly linked lists many types trees avl red black trees trees graphs evaluate technique real world applications file system implementations popular libraries results show mempick identify data structures high accuracy
inhibition entry hippocampus dorsal root ganglion drg inhibition methyl aspartate nmda receptor antagonist drugs current standard care neuronal diseases alzheimer disease dementia peripheral pain oxidative stress activates permeable trpm trpv recent studies indicate selenium potent trpm trpv channel antagonist hippocampus drg study investigated neuroprotective properties primary hippocampal drg neuron cultures aged rats given alone combination scopolamine scop thirty two aged months old rats divided four groups first second groups received placebo scop day respectively third fourth groups received intraperitoneal day scop respectively hippocampal drg neurons also stimulated vitro trpv channel agonist capsaicin trpm channel agonist cumene hydroperoxide found fully effective reversing scop induced trpm trpv current densities well errors working memory reference memory addition completely reduced scop induced oxidative toxicity modulating lipid peroxidation reducing glutathione glutathione peroxidase scop treatments also decreased poly adp ribose polymerase activity intracellular free concentrations apoptosis caspase caspase mitochondrial membrane depolarization values hippocampus conclusion current study reports cellular level scop different endocytotoxic cascades first time notably research indicates result remarkable neuroprotective memory impairment effects hippocampal neurons rats
objective poincare plot two dimensional state space approach timed signal plotted time delay enabling determination dynamic nature signals quantification poincare plot candidate estimating anesthesia dependent changes electroencephalogram eeg methods patients four different states anesthesia sevoflurane frontal eeg signals used construct poincare plots plot pattern quantified standard deviation voltage dispersion along line identity standard deviation perpendicular line identity ratio compared using spectral eeg features results significant stepwise decrease ratio observed stepwise increase sevoflurane concentration sevoflurane anesthesia ratio relative beta power delta power beta delta highly correlated conclusions poincare plot frontal eeg detect significant changes depth anesthesia induced different sevoflurane concentrations significance poincare plot useful technique detecting eeg changes induced anesthesia international federation clinical neurophysiology published elsevier ireland ltd rights reserved
prenatal development large number different cell types formed vast majority contain identical genetic material basis great variety cell phenotype function differential expression approximately genes mammalian genome transcriptional activity regulated many levels proteins including members basal transcriptional apparatus dna binding transcription factors chromatin binding proteins importantly chromatin structure dictates availability specific genomic locus transcriptional activation well efficiency transcription occur chromatin immunoprecipitation chip method assess chromatin modifications proteins arc present specific locus chip involves cross linking dna associated proteins immunoprecipitation using specific antibodies dna associated proteins followed examination precipitated dna sequences proteins last years chip become essential technique scientists studying transcriptional regulation chromatin structure using chip mouse embryos document presence absence specific proteins chromatin modifications genomic loci vivo mammalian development describe chip technique adapted mouse embryos
background aim study evaluate outcomes priming salvage radioimmunotherapy rit low dose external beam radiotherapy ebrt patients relapsed low grade non hodgkin lymphoma nhl methods patients received salvage rit without ebrt march february retrospectively reviewed single institution planning target volume ptv ebrt created adding expansion gross tumor volume depending anatomical location kaplan meier method via log rank employed analyze endpoints freedom progression ffp overall survival results identified patients received salvage rit without chemotherapy median follow months patients treated ebrt immediately prior rit received salvage rit alone median ffp reached patients underwent combination treatment months patients treated rit alone patients months significant difference two groups univariate analysis addition ebrt associated improved ffp hazard ratio confidence interval long term toxicities reported groups conclusions rit outcomes effects improved addition low dose ebrt immediately prior treatment relapsed nhl additional toxicity study hypothesis generating findings validated prospective studies
problem solving highlighted many mathematics curricula recently become one investigated topics field mathematics education extensive studies report developing students problem solving skills enhances understanding mathematics therefore focus investigating problem solving processes students processes analyzed using various measurement techniques data collected written verbal forms one techniques using verbal data think aloud method study investigates sixth grade students think aloud processes solving mathematical problem verbally study group consists sixth grade students selected according results problem solving test developed researchers think aloud process student videotaped transcribed collected data coded categorized frequencies categories determined compared according students performance solving mathematical problems results indicate students difficulty expressing thoughts problem solving students attempted operations numbers given spending almost time understanding problem students necessary computations correctly could reach solution could interpret result operation
context trustworthiness research results growing concern many empirical disciplines aim goals paper assess much trustworthiness results reported software engineering experiments affected researcher publication bias given typical statistical power significance levels suggest improved research practices method first conducted small scale survey document presence researcher publication biases software engineering experiments built model estimates proportion correct results different levels researcher publication bias review randomly selected software engineering experiments published period conducted provide input model results survey indicates researcher publication bias quite common finding supported observation actual proportion statistically significant results reported reviewed papers twice high one expected assuming researcher publication bias models suggest high proportion incorrect results even quite conservative assumptions conclusion research practices must improve increase trustworthiness software engineering experiments key improvement avoid conducting studies unsatisfactory low statistical power elsevier inc rights reserved
paper presents novel automated procedure discovering expressive shape specifications sophisticated functional data structures approach extracts potential shape predicates based definition constructors arbitrary user defined inductive data types combines predicates within expressive first order specification language using lightweight data driven learning procedure notably technique requires programmer annotations equipped type based decision procedure verify correctness discovered specifications experimental results indicate implementation efficient effective capable automatically synthesizing sophisticated shape specifications range complex data types going well beyond scope existing solutions
digital control high speed permanent magnet synchronous motor pmsm carried part mass reduction embedded systems paper focuses improving stability high speed pmsm digital control study stability closed loop system shows importance taking account constraints digital control delay discrete characteristics calculation decoupling terms inverse park transformation proposed decoupling done using discrete model system prediction evolution currents delay voltage calculated vector control applied machine three phase voltage source power width modulation pwm converter voltage modified rotor reference frame turns delay switching period voltage error caused rotation significant high speeds generally ratio switching frequency electrical output frequency becomes high stabilize system suggest predicting average electric angle motor application voltage vector efficiency shown time simulation
diet exercise important wellbeing people cancer family caregivers unfortunately little known behaviors time factors may influence engagement behaviors exploratory study examined influence chronic conditions symptom distress perceived social support exercise diet behaviors patients advanced cancer caregivers using actor partner interdependence mediation model apimem interdependence theory guiding frameworks secondary analysis uses self report data large rct patient caregiver dyads three time points baseline data collected within three months diagnosis months post baseline months post baseline number actor effects observed patient caregiver prior exercise diet significant predictors future exercise diet behaviors patient reported social support associated less patient exercise patient symptom distress associated poorer patient diet caregiver reported social support associated caregiver exercise better caregiver diet partner effects also observed patient exercise positively associated caregiver exercise patient comorbidities associated better caregiver diet caregiver reported social support associated better patient diet patient reported social support associated better caregiver diet despite challenges advanced cancer caregiving past exercise diet behavior remained significant predictor future behavior health problems perceptions social support within dyad may exert positive negative influence patient caregiver diet exercise
early years college students need learn program programming language important see differences programming languages rules proposing interactive self study system students acquire knowledge need data structures algorithms using multiple programming languages system gives students exercises outputs image student image compared correct image system system judges student image correct students program exerdses selected programming languages eventually system help students learn multiple programming languages especially solve problems regardless programming language
objectives analyze imagery women reconciling work family life explore beliefs opinions related experiences gender inequality methods applied qualitative methodology depth semi structured individual group women vocational training courses also conducted interviews experts gender equality results women experts interviewed manifest presence barriers reconciling work family organizations career advancement applicable legislation conclusions undercurrent collective imagination individual beliefs society allows maintenance values associated patriarchal organization sexual division labor socializing unequal gender roles required transformation work organization improve lives people
last decade games arguably become largest form leisure information systems however today games also increasingly employed variety instrumental purposes although games garnered substantial amount research attention last decade research literature scattered still lack clear reliable understanding games used placed established utilitarian hedonic continuum information systems address gap conducted meta analysis quantitative body literature examined reasons using games studies additionally compared findings across games intended either leisure instrumental use even though games generally regarded pinnacle form hedonically oriented iss results show enjoyment usefulness equally important determinants using though definitive role varies game types therefore posited games multi purpose iss nevertheless rely hedonic factors even pursuit instrumental outcomes present study contributes advances theoretical empirical understanding multi purpose iss ways used elsevier ltd rights reserved
background evaluation medication efficacy safety essential guarantee successful therapeutic outcome public health practices however larger distribution chain supply developing countries cameroon often challenged counterfeit drugs poor manufacturing storage degradation leading health patient adverse consequences yet access supply chain management strengthening arvs quality assurance outcomes remains poorly documented patients enrolled free arvs medications little documented quality assurance validity safety affected populations along supply chain management since methods cross sectional study conducted arvs distribution units centers central littoral south west regions cameroon arvs drugs samples included nevirapine efavirenz fixed dose combinations zidovudine lamivudine lamivudine stavudine zidovudine lamivudine nevirapine drugs packaging labeling assessed galenic assays performed national laboratory quality control medications expertise lanacome yaounde cameroon results study covered structures located eight different towns including central arvs store two regional pharmaceutical procurement centers thirteen hiv approved treatment centers management units total arvs products collected eight arvs drugs containing lamivudine stavudine presented white stains tablets however drugs standard tests performed others arvs products standards assays performed conclusion concluded arvs drugs freely accessible distributed plwha good quality cameroon however increase number patients haart since adoption test treat approach reach goals implementation new national antiretroviral regimen guidelines molecules boosted protease inhibitors continuous quality control assurance surveillance monitoring evaluation recommended assessment quality formulations susceptible degradation pediatric formulations averting rising multidrug resistance trend also desired
provide better service senior health care summarized screening studies traditional chinese anti aging materia medica tcam collected analyzed literature tcam screening studies using lifespan test animal models aging found screening methods tcam single herbs active ingredients tcam screened past years cell lifespan test fruit fly lifespan test galactose aging model widely used intensively studied screening methods however method establishing galactose aging model needs standardized galactose aging model completely substitute normal aging mouse model great success achieved screening studies tcam improve screening studies tcam suggest galactose aging model incorporated lifespan test new drugs traditional chinese medicine research guide
although majority veterans overweight obese many comorbid mental health disorders little known effective way intervene complex population case describes telephone based cognitive behavioral treatment depression weight management obese veteran bipolar disorder wife joined sessions leverage spousal support veteran evidenced variable levels physical activity mood fluctuations treatment although reported degree positive behavior change improved social support lose weight continued endorse moderate levels depressive symptomatology end nine session intervention case illustrates complexity treating chronic serious mental illness multimorbidities research needed inform interventions concurrently improve mental health symptomatology weight related outcomes chronic complex cases
paper employs control techniques analyze kinematic relationships via block diagrams planetary gear systems revealed tangent velocity equations contact point mechanical gearsets utilized plot block diagrams concepts feedback feedforward strategies adopted illustrate speed reduction increasing functions kinematics sensitivity analysis structural difference unusual planetary gears common ones also explained based characteristic equation feedback strategies structural constraints terms stability conditions cam controlled planetary gear illustrated constraint kinematic analysis using block diagram technique characteristic equation computational simulations sensitivity motion output planetary gear obtained correspondence control kinematics paper provides guide engineers various fields easily understand function mechanical design doi
age disease osteoporotic fractured osteoarthritic tissue related changes distribution cortical bone examined using multimodality approach including measurement local density geometry mechanical properties changes properties give rise instability increasing probability fracture contrast majority previously reported research study also focuses characteristic non circular femoral neck cross sectional geometry variation bone mineral density bmd around femoral neck twenty two osteoarthritic osteoporotic femoral neck slices collected elective trauma related arthroplasty cadaveric donor tissue controls tested mechanically using reference point indentation biodent active life technologies santa barbara scanned vitro based radiography intended replicate dual energy ray absorptiometry technique parameters measured regionally around circumference femoral neck allowing examination spatial variability within cortical bone fractured tissue less resistant indentation thinner superolateral segment compared segments groups bmd around fractured femoral necks appeared consistent nonfractured tissue bmd reduced superolateral segment groups cortical bone thin superolateral segment groups except osteoarthritic group thicker inferomedial segment osteoarthritic fractured groups resulting largest variation buckling ratio ratio cortical bone diameter cortical bone thickness around femoral neck fractured group age healthy controls appeared lower inferomedial cortical thickness whereas significant differences reference point indentation measurements density observed study highlighted several quality quantity related parameters may used improve prediction fracture risk
aim cross sectional study analyse quality life socio demographic characteristics family support satisfaction health services effect integrative community therapy among non institutionalised elderly adults without symptoms depression state rio grande norte brazil data elderly adults without depressive symptoms compared instruments used mini mental state examination short version geriatric depression scale clinical socio demographic questionnaire abbreviated version world health organisation quality life questionnaire family assessment device patient satisfaction mental health services rating scale elderly adults depressive symptoms lower quality life social relations domain without depressive symptoms addition compared without depression fewer elderly adults depressive symptoms attended integrative community therapy also reported low degree family involvement problem solving showed apathy regarding satisfaction health services results important implications decision making process regard strategies improving health status elderly adults depressive symptoms
little evidence barriers pain management relationships pain outcomes hospice patients cancer purpose study determine barriers reported hospice patients cancer caregivers relationships demographic characteristics patients pain cross sectional study used selected baseline data ongoing randomized clinical trial patient lay caregiver dyads receiving home level hospice care participants used internet enabled tablet complete valid reliable measures pain intensity pain management barriers barriers questionnaire items demographic characteristics responses indicate areas highest concern mean scores patients caregivers pain means disease progression constipation additionally areas highest concern mean scores caregivers addiction pain medicine causing one embarrassing things confusion mean scores ranged averaged patients ranged averaged caregivers mean barrier scores remain high different patients caregivers significantly related patients pain intensity however differences race ethnic hospice setting barrier scores patients hispanic heritage reported higher barrier scores non hispanic patients together findings support prior research findings also contribute new insights pain intensity pain barriers relevant hospices serving minorities cancer
background compulsive exercise proposed significant etiology development maintenance eating disorders eds resulting severe enduring pathology however studies investigated longitudinally adolescents eds aimed test adolescents show associations clinical variables previous research found adults methods three thousand one hundred sixteen girls boys clinical database investigated regarding prevalence frequency relation psychiatric symptoms associated features outcome denial illness common among adolescents therefore adjusted results adjusted prevalence girls prevalent bulimia nervosa previously found adults scored significantly higher non total severity level restriction negative perfectionism however minor differences non patients emotional distress hyperactivity suicidality self esteem among boys adjusted prevalence boys scored significantly higher non total severity initial influence year outcome although cessation associated remission conclusions common clinical feature adolescents eds cessation associated remission controlling denial illness less detrimental impact predicted recommend controlling denial studies adolescents exploration classification treatment implications
paper sets forth novel approach calculate levelized cost electricity lcoe using probabilistic model accounts endogenous input parameters approach applied example nuclear gas power project monte carlo simulation results show correlation input parameters significant effect model outcome controlling endogeneity statistically significant difference mean lcoe estimate change order input leverages observed moreover paper discusses role discounting options external costs detail contrast gas power project economic viability nuclear project considerably weaker elsevier ltd rights reserved
pathogenicity islands pais mobile integrated genetic elements contain diverse range virulence factors pais integrate host chromosome trna locus contains specific bacterial attachment site attb via integrase mediated site specific recombination generating attl attr sites identified conserved recombination modules integrases att sites previously described choleragenic vibrio cholerae pais novel cargo genes clustered regularly interspaced short palindromic repeat crispr associated proteins cas proteins type secretion system tss gene cluster identified vibrio pathogenicity island vpi insertion site cholerae strains contained recombination module two divergent type crispr cas systems identified differed cas protein homology content crispr repeat sequence identical among cholerae strains crispr spacer sequences number spacers varied silico analysis suggests crispr cas systems active phages plasmids type iii secretion system tss present cholerae strains island inserted trna serine insertion site vpi contained recombination module bioinformatics analysis showed two divergent tsss exist among strains examined crispr tss islands excised site specifically bacterial chromosome complete units cognate integrases essential excision data demonstrated identical recombination modules catalyze integration excision chromosome acquire diverse cargo genes signifying novel method acquisition crispr cas systems tsss importance work demonstrated presence crispr cas systems tsss pais work showed similar recombination modules associate different cargo genes catalyze incorporation bacterial chromosomes could convert strain pathogen different disease pathologies island ability excise chromosome distinct complete units possible transfer evolutionary analysis regions indicates acquired horizontal transfer pais units transfer similar case phage evolution pais modular structure different functional regions acquired identical recombination modules
incompetent aortic valve results aortic regurgitation retrograde flow blood left ventricle observed work parametrically characterized detailed changes intra ventricular flow diastole result physiological vitro left heart simulator lhs loss energy within level increased also assessed validated lhs consisted optically clear flexible wall modular holder two component planar digital particle image velocimetry used visualize quantify intra ventricular flow large coherent vortical structure engulfed whole observed control conditions cases regurgitant jet observed generate kinematic obstruction mitral valve apex preventing trans mitral jet generating coherent vortical structure regurgitant jet also observed impinge inferolateral wall energy dissipation rate edr trace mild moderate found respectively study first time performed vitro characterization intraventricular flow presence mechanistically formation kinematic obstruction appears cause increased edr metric quantifiable vivo edr increases non linearly fraction could potentially used metric grade severity develop clinical interventional timing strategies patients
nivolumab humanized immunoglobulin gamma kappa anti programmed cell death monoclonal antibody currently approved treatment several solid tumors recently gained accelerated approval classical hodgkin lymphoma chl relapsed progressed following autologous hematopoietic stem cell transplantation post transplantation brentuximab vedotin purpose article review immunophysiologic basis clinical efficacy toxicity nivolumab treatment chl addition review ongoing clinical trials potential future directions checkpoint inhibition treatment chl
according statistics skin cancer melanoma one deadly cancers time chance curing detected early stage early diagnostics obstructed low availability dermatology specialists low percentage patients taking regular diagnostics deal early diagnostics unavailability propose implementing portable automated diagnostic device available wide range medical institutions automated diagnostic systems yet capable providing final diagnosis enough detecting threats skin cancer therefore bringing automatic tools primary care physicians medical personal lot persons could save lives detecting cancer early stage provide automated diagnostic tool needed solve multiple tasks including skin images acquisition image processing calculating disease probability delivering diagnosis result tasks existing solutions commercial tool scientific methods lack ready use service paper author specialization one fields used implement proposed system ongoing project authors published elsevier
systematically reviewed differences hippocampal amygdala volumes adults childhood maltreatment related posttraumatic stress disorder ptsd healthy controls using terms adults mri magnetic resonance imaging posttraumatic stress disorder ptsd child abuse child maltreatment conducted searches several electronic databases identified studies met inclusion criteria included meta analysis hippocampal volume included meta analysis amygdala volume mean hippocampal amygdala volumes used determine effect sizes found bilateral reduction hippocampus amygdala ptsd group compared healthy controls effect sizes left right hippocampus left right amygdala respectively confidence intervals left right hippocampus respectively amygdala confidence intervals left right amygdala relatively studies available analysis limitation additionally sex diverse mri studies ptsd needed determine whether sex plays significant role hippocampal effects associated childhood onset trauma elsevier ireland ltd rights reserved
dlbs bioactive protein extract containing lumbricus rubellus known antithrombotic thrombolytic activity present study aimed assess safety aspect dlbs preclinical setting included observation toxic signs acute repeated administrations drug effect prenatal development drug interaction acute toxicity study high dose level dlbs well tolerated subchronic toxicity study doses dlbs per day mortality observed parameters observed normal prenatal developmental toxicity observed adverse effect level noael dlbs observed moderate dose coadministration dlbs clopidogrel aspirin cause gastric lesions except three drugs coadministrated taken together results present study suggested dlbs safe long term administration caution high dose used pregnancy used combination one antiplatelet drugs
gut microbes capable producing neurotransmitters found human brain evidence accumulating support view gut crobes influence central neurochemistry behavior irritable bowel syn drome regarded prototypic disorder brain gut microbiota axis responsive probiotic therapy translational studies indi cate certain bacteria may impact stress responses cognitive functioning manipulating gut microbiota psychobiotics prebiotics even antibiotics offers novel approach altering brain func tion treating gut brain axis disorders depression autism
background objectives overconfidence errors well replicated cognitive bias psychosis however prior studies sometimes failed find differences patients controls difficult tasks pursued hypothesis overconfidence errors exaggerated participants liability psychosis relative controls feel competent respective topic deem question easy whereas subjective competence likely enhances confidence low psychosis liability well still expected find residual caution latter group methods adopted psychometric high risk approach circumvent confounding influence treatment total individuals general population administered task modeled wants millionaire quiz participants requested endorse one four response options graded confidence asked provide ratings regarding subjective competence knowledge domain well subjective difficulty item results line assumption overconfidence errors increased overall participants scoring high paranoia checklist core paranoia subscale mean pattern results particularly prominent items participants considered competent rated easy limitations results need replicated clinical sample discussion support hypothesis subjective competence task difficulty moderate overconfidence errors psychosis trainings teach patients fallibility human cognition may help reduce delusional ideation published elsevier ltd
research introduces concept feeling known belief others developed accurate opinions one traits characteristics team literature various theoretical streams posit acquiring sense known understood central human motivation leads positive outcomes individuals present research links team member sense feeling known team member reports interpersonal trust personal learning project satisfaction large sample project teams using longitudinal study design research finds feeling known indeed strong predictor proximal distal team member outcomes additional analyses reveal team members sense feeling known plays role predicting outcomes face face virtual team members despite fact virtual team members report feeling less known face face team members practical significance results discussed
continuous development science technology actual data integration operating path also change greatly better improve transmission accuracy overall data information guarantee optimal establishment computer network security system accuracy overall system improve fundamentally efficient computer security treatment measures established efficient network model operates paper simply analyzes connotation computer network security risk assessment model intensively interprets principle fuzzy theory composition neural network model finally discusses neural network model fuzzy theory fusion system computer network security paper aims verify system security performance effective data analysis
advancement information technology playing increasing role use information systems comprising relational databases databases used effectively collaborative environments information extraction consequently vulnerable security threats concerning ownership rights data tampering watermarking advocated enforce ownership rights shared relational data providing means tackling data tampering ownership rights enforced using watermarking underlying data undergoes certain modifications result data quality gets compromised reversible watermarking employed ensure data quality along data recovery however techniques usually robust malicious attacks provide mechanism selectively watermark particular attribute taking account role knowledge discovery therefore reversible watermarking required ensures watermark encoding decoding accounting role features knowledge discovery original data recovery presence active malicious attacks paper robust semi blind reversible watermarking rrw technique numerical relational data proposed addresses objectives experimental studies prove effectiveness rrw malicious attacks show proposed technique outperforms existing ones
paper present study concerning new approach automatic detection analysis body language propose method extracting information related nonverbal communication persons approach based kinect sensor processes image provides many image features study final goal provide blind users access information completely hidden
educators parents alike seeking innovative ways introduce young students computer programming hope capture children attention foster learning time goal work introduce elementary students fundamentals computer programming also help explore complex concepts engaging way studies shown factors inspire children continued interest sometimes vary gender age work specifically addresses incorporate elements appeal potential differences motivation study describes design implementation computer microworld game designed introduce core constructs techniques computer programming instructing virtual robot complete obstacle courses students become familiar core programming concepts algorithms repetition conditional logic debugging functions optimization conducted several interactive sessions group elementary school students order evaluate effectiveness game results showed game effectively familiarized students computer language constructs essentials algorithmic thinking students quickly able learn core programming concepts apply concepts free form solutions
chronic cerebral hypoperfusion cch recognized important cause vascular dementia alzheimer disease two prominent neurodegenerative diseases causing memory impairment elderly however effective therapy cch induced memory impairment yet established grape seed polyphenol extract gspe powerful antioxidant properties protects neurons glia ischemic injury potential use prevention cch induced memory impairment yet investigated cch related memory impairment modeled rats using permanent bilateral occlusion common carotid artery morris water maze task used evaluate memory levels acetylcholinesterase choline acetyltransferase acetylcholine used evaluate cholinergic function oxidative stress assessed measuring enzyme activity superoxide dismutase glutathione peroxidase malonic dialdehyde catalase found oral administration gspe month rescue memory deficits also found gspe restores cholinergic neuronal function represses oxidative damage hippocampus cch rats propose gspe protects memory cch rats reducing ischemia induced oxidative stress cholinergic dysfunction findings provide novel application gspe cch related memory impairments copyright wolters kluwer health inc rights reserved
low back pain various etiologies common clinical presentation young athletes article discuss utility spect bone scintigraphy evaluation low back pain young athletes spectrum lower spine lesions caused sports injuries identifiable bone scan presented along strategies avoid unnecessary irradiation young patients also covered pitfalls diagnosis due referred pain phenomenon normal skeletal variants specific age group
availability heterogeneous cpu gpu systems opened door new opportunities development parallel solutions tackle complex biological problems reconstruction evolutionary histories among species represents grand computational challenge addressed exploiting kind hardware designs research study application heterogeneous computing opencl accelerate one well known objective functions inferring phylogenies phylogenetic parsimony function purpose undertake design cpu gpu kernel implementations relevant function proposing heterogeneous cpu gpu multidevice approach distributes multiple parsimony evaluations among processing devices experiments real nucleotide data sets comparisons parallel implementations give account benefits proposal paper obtaining significant parallel results combining cpu gpu capabilities accordance characteristics input data
paper pursues inquiry relationship ethnicity development largest authoritarian country contemporary world people republic china engages theoretical literature ethnic diversity development general also pays special attention political economy logics unique authoritarian systems focusing western part china decade since launch china western development program xibu kaifa paper utilizes data two censuses together nighttime streetlight imagery data analyze overall relationship ethnicity development provision also analyzes changes relationship period paper finds ethnic minority concentration negatively correlates economic development years across western provinces also finds counties non autonomous provinces historically integrated rest china autonomous provinces positive systematic correlation changes ethnic minority concentration changes development year period counties autonomous provinces hand show opposite trend using three case studies tibet inner mongolia xinjiang paper concludes although general tendency ethnic minority concentrated areas less developed ultimately groups prosper less depends upon specific economic development political control logics chinese state implements authors published elsevier ltd
endolichenic fungi diverse groups predominantly filamentous fungi reside asymptomatically interior lichen thalli natural products endolichenic fungi isolated variety different lichen species attracting increased attention potential produce bioactive metabolites possessing new structures representing different structural classes evident steady increase publications devoted endolichenic fungal metabolites past decade since first report endolichenic secondary metabolites bioactive metabolites produced endolichenic fungi originate multiple biosynthetic pathways occupy different chemical structure classes including steroids quinones terpenoids peptides xanthones sulfur containing chromenones etc endolichenic fungal metabolites possess diverse array bioactivities anticancer antiviral antibacterial antifungal anti alzheimer disease review provides first thorough assessment endolichenic fungi biodiversity secondary metabolites associated bioactivity review highlight bioactive metabolites reported recent years endolichenic fungi well discussing potential symbiotic fungi sources new diverse natural products varying bioactivities
automatized procedure parameterization fundamental equations state eos explicit terms helmholtz energy based molecular simulation data presented simulation runs carried via cloud based framework combines multiple distributed computing resources user friendly graphical user interface ensures minimal knowledge background operations required order exemplify capabilities approach eos ethylene oxide created compared data literature elsevier rights reserved
thermal hydraulics air cooled finned heat transfer tube banks analyzed ansys fluent cfd code assuming periodic boundary condition region interest normalization group rng theory based epsilon model used reference turbulence model two turbulence models used compare results standard epsilon model realizable epsilon model loss coefficients finned heat transfer tube function reynolds number calculated using rng epsilon model standard epsilon model results band measured data case one pass model six pass finned heat transfer tube banks calculated using whole pass model well one pass model transfers calculated outlet conditions next pass calculation air temperature distribution along six passes compared result calculated one dimensional system code results agree however evaluated number pass slightly higher measured data evaluated pressure loss coefficient measured data scattering band elseviet ltd rights reserved
purpose evaluate criterion validity diagnostic utility scoff brief eating disorder screening instrument mexican sample methods study conducted two phases phase involved administration self report measures scoff eating disorder inventory edi students aged years age female three colleges universidad autnoma san luis potosi mexico phase random subsample students participated eating disorder examination structured interview yields diagnoses analyses conducted evaluate scoff criterion validity examining correlations scores scoff edi scoff ability differentiate diagnosed cases non cases results edi subscales showed high correlations scoff scores proving initial evidence criterion validity score two points scoff optimized sensitivity specificity cutoff scoff correctly classified half cases ppv screened majority non cases npv providing evidence criterion validity analyses repeated separately men women yielding gender specific information scoff performance conclusion taken whole results indicated scoff useful tool identifying mexican university students risk eating disorders
analyze narratives people diagnosed adhd attention deficit hyperactivity disorder bpd borderline personality disorder search new evidence improved efficacy treatments environments evidence suffering particularly social suffering revealed reality great presence powerfull narratives must necessarily considered articulate new paths improve therapeutic procedures conventional treatment aimed towards healing people research experience propose understand stories grief evidence clinic narratives suffering subjectivities become auditors healthcare quality documents allowing evaluating improving practices incorporating different social understanding disorders perspective implemented social approach based particular way social theory emotions anthropology emotions ethnographic narrative materials analyzed relate mainly fieldwork author researchs conducted author past five years spain mexico
inflammation defined formany years response tissue injury infection forced reconsider definition avalanche reports molecules cells associated inflammation activated expressed high concentration large variety states absence tissue injury infection modest increases concentration reactive protein circulating marker inflammation reported associated astounding number conditions lifestyles felt associated poor health conditions represent reflect minor metabolic stresses recent years learned inflammation triggered sentinel cells monitor tissue stress malfunction deviations optimal homeostasis molecules participate inflammatory process play role restoring normal homeostasis accordingly suggest inflammation redefined innate immune response potentially harmful stimuli pathogens injury metabolic stress antonelli kushner time redefine inflammation
background police exposed wide range stressors especially true developing countries jamaica exposure psychosocial stressors use maladaptive coping styles result mental ill health aims examine relationship work characteristics coping mental health jamaican police officers test whether work characteristics indirectly associated mental health outcomes perceived job stress job satisfaction methods police officers jamaican police force completed questionnaire using cross sectional design analysed data using hierarchical regression results study group consisted police officers response rate negative work characteristics lower levels positive work factors work support emotion focused coping styles associated increased levels depression subjective feelings anxiety positively associated negative work characteristics emotion focused coping relationship work characteristics mental health outcomes mediated perceived stress job satisfaction mediated relationship positive work characteristics depression conclusions stress management intervention programmes address modifiable work conditions monitor stress levels reduce maladaptive coping
design alternatives construction projects compared concurrently taking various criteria consideration costs functionality constructability case study introduces comparison process based lifecycle costing lcc two design alternatives irrigation project seyhan river yedigoze imamoglu irrigation project implemented southern region turkey decisions related irrigation projects turkey important effect agricultural development high amounts allocated national budget implementation regard comparing design alternatives properly design development stage critical exploring superior design aim case study show considering facility initial construction costs ignoring lcc may lead wrong decisions example case irrigation project undertaken turkey comparison two different design alternatives revealed design alternative pipe network concrete covered open main channel superior design alternative pipe network concrete covered open main channel perspective lcc technical criteria constructability operation easiness water saving american society civil engineers
first mouse molar common model odontogenesis research particularly focused prenatal development however functional dentition forms postnatally histogenesis morphogenesis tooth completed roots form tooth physically anchors jaw work studied birth eruption assessing morphogenesis proliferation apoptosis correlating remodeling surrounding bony tissue completed crown formation postnatal days development tooth root initiated cell proliferation dental epithelium reduced shifted downward apical region forming root contrast proliferation maintained increased mesenchymal cells dental follicle later stages tooth eruption cell proliferation suddenly ceased withdrawal cell cycle correlated tooth mineralization mesenchymal differentiation apoptosis observed stages postnatal morphogenesis playing role removal cells osteoblasts mandibular region working together osteoclasts remodel bone around developing tooth advanced developmental stages apoptotic cells bodies accumulated cell layers tooth cusps path eruption three dimensional reconstruction developing postnatal tooth bone indicates alveolar crypts form resorption underneath primordia whereas ridges form active bone growth teeth roots form functional complex
present fabsim toolkit developed simplify range computational tasks researchers diverse disciplines fabsim flexible adaptable allows users perform wide range tasks ease also provides systematic way automate use resources including hpc distributed machines make tasks easier repeat recording contextual information demonstrate present three use cases fabsim enhanced research productivity include simulating cerebrovascular bloodflow modelling clay polymer nanocomposites across multiple scales calculating ligand protein binding affinities
pediatrics dynamic discipline awareness hope actualizing outstanding achievements field child health century beyond improved lifestyle quality children health likely reduce burden adult diseases enhance longevity seeds adult diseases sown childhood identification decoding human genome expected revolutionize practice pediatrics day far patient walk doctor chamber electronic digital health history palmtop decoded genomic constitution reduced burden genetic diseases selective abortions defective fetuses replacement bad genes good ones genetic engineering availability totipotent stem cells developments transplant technology likely revolutionize management variety hematologic cancers life threatening genetic disorders possibility producing flawless designer babies advances assisted reproductive technologies arts likely mired several ethical legal issues availability newer vaccines recombinant technology emerging infective non infective lifestyle diseases likely improve survival quality life going greater focus patient disease rather disease per practicing holistic pediatrics effective utilization alternative complementary strategies health care due advances technology pediatrics may get dehumanized true healer simply rely technology must spiritual bond patient physician exploiting concept psycho neuroimmunology body mind interactions years come physicians likely play god medicine achieve immortality anything born must die accordance nature recycling blueprint medical science likely improve longevity goal improve quality life
background fatigue one debilitating adverse effects cancer therapy identifying biomarkers early cancer therapy may help understand biologic underpinnings persistence fatigue following therapy objective aimed identify early biomarkers fatigue examining correlations levels cytokines external beam radiation therapy ebrt persistence fatigue year following treatment completion men nonmetastatic prostate cancer methods sample men nonmetastatic prostate cancer scheduled receive ebrt followed baseline midpoint ebrt year following ebrt demographic clinical data obtained chart review functional assessment cancer therapyyfatigue administered measure fatigue levels plasma cytokine levels determined using bio rad bio plex cytokine assay kits results significant correlations observed levels interleukin interferon yinduced protein interferon alpha interferon stromal cell derived factor alpha worsening fatigue conclusions immunological changes prior chronic fatigue development may reflect long term response radiation therapyyinduced damage implications practice early biomarkers chronic fatigue related cancer therapy help advance understanding etiology distressing symptom help nurses identify patients risk developing chronic fatigue cancer treatment information also aid patient education well symptom management
purpose study find motor topology offers best combination permanent magnet reluctance torque components well best possible torque per volume ratio perform task topological optimization method using genetic algorithms embedded experience based design proposed interacting principle permanent magnet reluctance torque components importance shown results obtained proposed optimization method discussed compared results obtained using state art machine design
cmos current mode analog multiplier divider circuit presented suited standard cmos fabrication successfully employed wide range analog signal processing applications measurement results cmos test chip prototype verify approach employed circuit consumes using single supply voltage requires silicon area
little known mechanisms mediating development repetitive behaviors human animals deer mice reared environmental enrichment exhibit fewer repetitive behaviors greater indirect basal ganglia pathway activation adults reared standard cages developmental progression behavioral neural circuitry changes characterized assessed development repetitive behavior deer mice using longitudinal cohort design repeated testing negated expected effect cohort analyses showed progression repetitive behavior arrested week differed significantly controls weeks moreover reductions repetitive behavior associated increasing activation indirect pathway nuclei males across adolescence females findings provide first assessment developmental trajectories within support indirect pathway mediation repetitive behavior male deer mice
kernel discriminant subspace learning technique effective exploit structure image dataset high dimensional nonlinear space however large scale image recognition applications technique usually suffers large computational burden although kernel accelerating methods presented greatly reduce computing time simultaneously keep favorable recognition accuracy still challenging paper introduce idea parallel computing kernel subspace learning build parallel kernel discriminant subspace learning framework framework firstly design random non overlapping equal data division strategy divide whole training set several subsets assign computational node subset separately learn kernel discriminant subspaces subsets without mutual communications finally select appropriate subspace classify test samples built framework propose two novel kernel subspace learning approaches parallel kernel discriminant analysis pkda parallel kernel semi supervised discriminant analysis pksda show superiority proposed approaches terms time complexity compared related methods provide fundamental supports framework experiment establish parallel computing environment employ three public large scale image databases experiment data experimental results demonstrate efficiency effectiveness proposed approaches
identification antigen inducing specific class antibody prime objective peptide based vaccine designs immunodiagnosis antibody productions urge introduce reliable system high accuracy efficiency prediction present study novel multilevel ensemble model developed prediction antibodies igg iga epitope length important training model efficient use variable length epitopes ensemble approach seven different machine learning models combined predict variable length epitopes proposed model igg specific epitopes achieves accuracy iga specific epitopes achieves accuracy repeated fold cross validation proposed model compared existing system igpred model outcome proposed model improved european federation immunological societies published elsevier rights reserved
algorithm derive transfer functions continuous discrete systems presented given system arbitrary order arbitrary topology structure analyzed construct algorithm nodal equations laplace transformation signal flow graph resorting algorithm develop computer aid analysis software deriving transfer function continuous discrete system example analyzing lattice continuous discrete system shows algorithm valid
lead ranks one serious environmental poisons world amongst toxic heavy metals known biological function useful human body case lead toxicity due consumption herbal medicine discussed case presented gastrointestinal complaints history intake herbal medicines diabetes control past months analysis powdered herbal medicine procured ayurveda practitioner found high content lead responsible lead toxicity patient regular followup improved symptomatically chelating therapy blood lead levels gradually improved regular awareness programs conducted population regarding possible exposure home made herbal remedies general public made aware dangerous side effects lead heavy metals health
traumatic life events robustly associated various psychosis outcomes including increased risk psychotic disorders prodrome psychosis dimensional measures psychotic symptoms attenuated positive psychotic symptoms however trauma exposure linked various mental disorders therefore specificity trauma exposure psychosis remains unclear review focuses two understudied areas trauma psychosis literature specificity trauma psychosis relation disorders often result post trauma proposed mechanisms uniquely link trauma psychosis begin discussing underlying connection trauma exposure entire psychosis spectrum focus influence trauma type specific psychotic symptoms consider principles multifinality equifinality useful elucidating trauma psychosis relationship versus trauma disorder relationship next discuss several cognitive neurobiological mechanisms might uniquely account association trauma psychosis well role gender lastly review important methodological issues complicate research trauma psychosis ending clinical implications field elsevier ltd rights reserved
battery electric vehicle uses electric energy stored battery supply power electric motor estimation accurate electric range important matter consumer fear running electricity driving often referred range anxiety article analyses quantifies influence driving aggressiveness battery life order achieve modification new european driving cycle performed simulating progressively aggressive behaviours calculation energy consumption accordingly vehicle range performed complete vehicle model implemented matlab simulink improvement battery model presented allowing faster processing methodology presented contribute efficient management power consumed vehicle decrease range anxiety
paper presents novel modular portable low power electroencephalography eeg acquisition system brain computer interface bci application system based versatile microcontroller mspf acquire eeg channels single supply prototype supports passive active electrodes also designed built additionally graphic visualization interface developed open source programming language processing common mode rejection ratio input referred noise magnitude phase frequency response measured analog eeg channel requirements comply international federation clinical neurophysiology guidelines furthermore four noise distortion parameters input signals evaluated adc channel based ieee standard power spectrum eeg recordings using prototype commercial amplifier usbamp compared open closed eyes conditions alpha band reactivity verified spectral information retrieval eeg alfa peak attained prototype quite similar commercial system noise level reduced using active instead passive electrodes expected shown analog pre processing noise design considerations effective ways get good quality eeg signal enhance certain portions frequency spectrum embedded recording system improves acquisition eeg frequency bands interest beta eeg rhythms motor imagery bci application rejecting unwanted components design possible reduce noise interferences eeg signal decrease computational workload digital post processing thus may increase likelihood achieving completely stand alone bci system clinical applications
purposes study evaluate psychometric properties reliability validity chinese version glover nilsson smoking behavioral questionnaire sbq assess behavioral nicotine dependence among community dwelling adult smokers taiwan methods used survey design administration validation total adult smokers completed survey assess behavioral dependence nicotine dependence depression social support demographic smoking characteristics data analysis included descriptive statistics internal consistency reliability test exploratory factor analysis independent test pearson product moment correlation results showed sbq good internal consistency reliability stability week test retest reliability extracted one factor explained variance indicating construct validity scale acceptable concurrent validity significant positive correlation sbq nicotine dependence depression time smoking negative correlation sbq age exercise habit instrument discriminant validity supported significant differences high low moderate nicotine dependence smokers greater years old years old younger smoked years less smoking years item sbq satisfactory psychometric properties applied sample taiwanese adult smokers scale feasible valid use assess smoking behavioral dependence
analyse impact current alternative stricter car legislation transport related emissions uptake electric vehicles reduction oil consumption total energy system costs beyond apply times based energy system model europe results show stricter target cars could reduce total transport emissions oil dependence compared current legislation stricter regulatory car target met deployment efficient internal combustion engine cars higher shares total system costs increase less analysis indicates deployment decarbonisation power system including higher shares variable renewables synergistic sensitivity analysis shows deployment would sharply increase learning rates reaching shares finally study highlights besides legislating cars policies transport sectors modes needed curb transport related emission growth authors published elsevier ltd
nowadays remote collaborative learning tools computer science education mostly emphasize providing learning resources realizing virtual collaborative learning environment students many people field tend mind fixed process improvement collaboration whole notice individuals may different roles impacts type teamwork usually supervisor team offers support members collaborative learning environment however support may always accessible students demand therefore paper describes cloud based tool support software engineering practice courses collaboration remote tutors system utilizes cloud storage platform provide sharing multimedia study materials better management project developing cycles remote collaborative component called virtual debug laboratory designed improve share students debugging experience team innovative feature system amplifies role tutoring remote collaborative learning environments tutors real time assist students debugging actual project developing demonstrate step step students process debugging results analyzed data regarding use system indicate system potentially enhance students abilities project developing debugging software engineering practice courses hope preliminary data provide future reference software education community
bes iii experiment institute high energy physics beijing china aimed precision measurements annihilation energy range till gev world largest samples psi psi events unique samples xyz data already collected expected increase data volume coming years required significant evolution computing model namely shift centralized data processing distributed one report summarizes current design bes iii distributed computing system key decisions experience gained years operations
background aims hygiene hypothesis lack childhood exposure microorganisms increases susceptibility allergic diseases altering immune development proposed explanation increasing incidence inflammatory bowel disease ibd however data relationship oral hygiene development ibd study results inconsistent investigated association poor oral health risks ibd ulcerative colitis crohn disease methods performed population based cohort study individuals followed years residents municipalities uppsala county sweden years older invited among examined tooth loss dental plaques oral mucosal lesions time study entry exposure data collected questionnaires patients later developed ibd identified international classification codes swedish national patient cause death registers cox proportional hazards regression used estimate hazard ratios ibd results national patient cause death registers identified individuals developed ibd developed developed incidence rate per person years found inverse relationship poor oral health ibd especially individuals severe oral problems loss teeth teeth examined associated lower risk ibd hazard ratio confidence interval dental plaques covered tooth surface negatively associated hazard ratio confidence interval conclusions population based cohort study people sweden associated poor oral health reduced risk future ibd
two children congenital heart disease status post surgical correction presented prolonged constitutional symptoms hepatosplenomegaly pancytopenia concern malignancy prompted bone marrow biopsies without evidence thereof case echocardiography identified multilobulated vegetation conduit valve case transthoracic transesophageal intracardiac echocardiography performed without evidence cardiac vegetations however pulmonic emboli raised concern infective endocarditis patients underwent surgical resection infected material histopathologic evidence infective endocarditis diagnostics identified elevated cytoplasmic antineutrophil cytoplasmic antibodies antiproteinase antibodies addition acute kidney injury crescentic glomerulonephritis renal biopsy serologic evidence infection bartonella henselae observed patients cases highlight potential multiorgan involvement may confound diagnosis culturenegative infective endocarditis caused henselae
continuous growth population consequent growing need drinking water global problem effective use rainwater toilet flushing laundry gardening washing thus saving drink water overall urban drainage presents classic set modern environmental challenges need cost effective socially acceptable technical improvements existing systems need assessment impact systems need search sustainable solutions paper describes comprehensive rainwater management approaches contains overview source control techniques well practical examples rainwater use non potable purposes authors published elsevier ltd
thermoelectric generators tegs niche candidate field energy management electrical generator devices generally comprehensive accurate design techniques tegs thermoelectric generators reduced current approach rca complex time consuming processes study develops simple comprehensive accurate teg designing technique based rca proposed method predict efficient teg architecture accuracy comparing rca wide range possible temperature present teg applications moreover proposed method predicts electrical outputs high accuracies electrical current accuracy thermoelectric potential difference accuracy power output accuracy engineering approach save significant amount time reduce complexity teg teg design process moreover technique easily used without broad knowledge design tegs elsevier ltd rights reserved
infectious diseases caused multidrug resistant mdr enterobacteriaceae exponentially increased past decade major concern hospitals first part work compared proteome profile mdr susceptible clinical isolates escherichia coli klebsiella pneumoniae order identify possible biological processes associated drug resistance susceptible phenotypes using label free approach second part used immunoproteomics approach identify immunoreactive proteins isolates total proteins identified mdr susceptible coli respectively evidencing biological processes related translation upregulated coli mdr upregulation processes related catalytic activity pneumoniae mdr mdr strains show downregulation processes related amino acid activation trna amino acylation data also suggest mdr strains higher immunoreactivity susceptible strains application high throughput mass spectrometry bioinformatics study modulation biological processes might shed light characterization multidrug resistance bacteria institut pasteur published elsevier masson sas rights reserved
stealth technology terms absorption electromagnetic waves valuable research area military purposes development radar absorbing materials ram actively researched quite long time ram design weight thickness absorptivity environmental resistance mechanical strength key factors therefore development ram low density high strength challenging task alternative research interest shifted towards radar absorbing structures ras metamaterial one lucrative options development ras metamaterials new class ordered composites exhibit exceptional electromagnetic properties readily observed nature built microstructure small compared wavelength operation metamaterials designed effective permittivity permeability values large small even negative selected frequency review paper first place stealth technology brief concept metamaterials context conventional materials discuss reflection theory metamaterials stealth point view next section deals recent progress towards application electromagnetic absorbers future prospects especially higher frequency region
paper develops real laboratory anti lock braking system abs vehicle conducts real experiments verify ability abs prevent vehicle wheel locked braking two controllers pid fuzzy logic tested analysis comparison abs laboratory designed bachelor master students simulate analyze performances abs different control techniques various roads load conditions paper provides educational theories practices design control system dynamics
two systematic methods designing low voltage log domain complex filters introduced paper first one based transposition signal flow graph representation linear domain complex leapfrog prototype filter corresponding one log domain last one based transposition wave equivalents elements complex passive prototype filter corresponding log domain complex equivalents transpositions performed employing appropriate set complementary operators facilitates derivation low voltage log domain filter configurations two design examples given order log domain complex transfer function realized order fulfill bluetooth specifications derived log domain filter structures operate single power supply voltage behavior evaluated simulation results addition comparison concerning important quality factors proposed structures performed obtained results discussed
infinity norm relates maximum frequency response function infinity control method focuses case vibration excited fundamental frequency norm relates output energy systems input pulses white noises norm control method weighs overall vibration performance systems trade performance frequency domain time domain may achieved integrating two indices mixed vibration control method based linear fractional state space representation modal space piezoelectric flexible structure uncertain modal parameters modeled residual high frequency modes mixed dynamic output feedback control design method proposed suppress structural vibration using linear matrix inequality lmi technique initial populations generated designing robust control laws different infinity performance indices robust norm performance index closed loop system included fitness function optimization flexible beam structure piezoelectric sensor piezoelectric actuator used subject numerical studies compared velocity feedback control method numerical simulation results show effectiveness proposed method
effectiveness situ remediation treat contaminated aquifers limited degree contact injected treatment chemical groundwater contaminant study candidate designs actively spread treatment chemical contaminant generated using multi objective evolutionary algorithm design parameters pertaining amount treatment chemical duration rate injection optimized according objectives established remediation maximizing contaminant degradation minimizing energy material requirements groundwater contaminants different reaction sorption properties influence ability degraded situ remediation optimization conducted six different combinations reaction rate coefficients sorption rates constants represent remediation common groundwater contaminants trichloroethene tetrachloroethene toluene using treatment chemical permanganate results indicate active spreading contaminants low reaction rate coefficients conducted using greater amounts treatment chemical mass longer injection durations relative contaminants high reaction rate coefficients contaminants slow sorption contaminants heterogeneous aquifers two different design strategies acceptable one injects high concentrations treatment chemical mass short duration one injects lower concentrations treatment chemical mass long duration thus decision makers select strategy according preference material energy use finally scenarios high ambient groundwater velocities injection rate used active spreading high enough groundwater divide encompass entire contaminant plume elsevier rights reserved
substantial harm could result concurrent cigarette cigarette use dual use undermine smoking cessation perceptions chemical exposure resulting harms may influence dual use conducted probability based phone survey adult cigarette smokers analyzed results subjects experiment smokers heard hypothetical scenario cigarettes cigarettes amount harmful chemicals cigarettes chemicals cigarettes chemicals present cigarettes smokers indicated scenario would change interest dual use perceived health harms smokers heard products amount chemicals interested initiating increasing dual use however smokers interested told cigarettes chemicals cigarettes chemicals cigarettes chemicals present cigarettes individuals told cigarettes chemicals likely amount scenario perceive cigarettes would harmful cigarettes harm perceptions partially explained relationship chemical scenario dual use interest smokers associated higher chemical amounts cigarettes versus cigarettes greater health harms cigarettes thus expressed increased interest dual use findings suggest disclosing amounts chemicals cigarette smoke cigarette aerosol could unintentionally encourage dual use elsevier inc rights reserved
background cardiomyocytes resistant radiation however cardiac radiation exposure causes coronary microvascular endothelial inflammation perturbation implicated pathogenesis heart failure particularly preserved ejection fraction hfpef radiotherapy breast cancer results variable cardiac radiation exposure may increase risk methods conducted population based case control study incident female residents olmsted county minnesota cases controls underwent contemporary radiotherapy breast cancer computed tomography assisted radiotherapy planning controls matched cases age tumor side chemotherapy use diabetes mellitus hypertension mean cardiac radiation dose mcrd patient calculated patient computed tomography images radiotherapy plan results mean age radiotherapy years cases hfpef reduced measured cases measurement mean interval radiotherapy years odds higher patients history ischemic heart disease atrial fibrillation mcrd range higher cases controls odds ratio confidence interval per log mcrd hfpef reduced increased odds hfpef increasing mcrd remained significant adjustment risk factors sensitivity analyses matching cancer stage rather tumor side patients experienced new recurrent ischemic events radiotherapy onset conclusions relative risk hfpef increases increasing cardiac radiation exposure contemporary conformal breast cancer radiotherapy data emphasize importance radiotherapy techniques limit mcrd breast cancer treatment moreover data provide support importance coronary microvascular compromise pathophysiology hfpef
projection computer graphics images walls architecture known projection mapping used widely applied many fields projection mapping relative alignment projected images target important efficiency projection mapping may reduced due misregistration however process alignment manual time consuming solve problem propose automatic alignment method uses depth information geometrical characteristics plane method enables correction distorted image projected arbitrary angle result distortion reduced applying proposed method evaluated error rate defined performing additional experiments evaluating effect method part future works
people frequently use internet obtain information including information health lack understanding people living hiv plhiv use internet care treatment decisions secondary analysis interviews individuals initiated hiv care urban midwestern medical center mentioned internet use analyzed using qualitative content analysis explore used internet process initiating hiv care hiv care initiated sample less one month three years post diagnosis participants discussed internet source information diagnosis influenced care treatment decisions five themes predominant internet alerted possibility hiv internet showed solution available iii internet influenced decisions care internet empowered participate treatment decisions internet gave hope future results suggest internet potential provide information profoundly influence plhivs acceptance care treatment decisions clinicians face new reality patients use internet resources obtain information shape opinions hiv treatment care initiation decision making guiding plhiv selection online resources one approach educating empowering individuals cope diagnosis contemplate decisions regarding hiv care treatment wiley periodicals inc
sexual abuse children adolescents places victims risk contracting sexually transmitted infections stis represents important public health issue timely diagnosis management stis prevent negative long term health effects important forensic implications emergency department common setting patients initially present reported sexual abuse important emergency care providers understanding recommended approach sti screening management patients
biological soil crusts biocrusts communities cyanobacteria algae microfungi lichens bryophytes varying proportions live within immediately top uppermost millimeters soil arid semiarid regions biocrusts highly relevant ecosystem processes like carbon nitrogen water cycling correct characterization spatial distribution required following objective considerable efforts devoted identification mapping biocrusts using remote sensing data several mapping indices developed however transferability different regions rarely tested study investigated transferability two multispectral indices crust index biological soil crust index bsci two hyperspectral indices continuum removal crust identification algorithm crcia crust development index cdi three sites dominated biocrusts differences soil vegetation composition whereas multispectral indices important valuable tools first approaches map classify biological soil crusts hyperspectral data indices developed allowed classify biocrusts much higher accuracy multispectral indices showed kappa kappa values hyperspectral indices obtained good classification accuracy kappa similar study area developed newly tested region results highlight capability hyperspectral sensors identify specific absorption features related photosynthetic pigments chlorophyll carotenoids also limitation multispectral information discriminate areas dominated biocrusts vegetation bare soil based results conclude remote sensing offers important valid tool map biocrusts however spectral similarity main surface components drylands biocrusts demand mapping indices based hyperspectral information correctly map areas dominated biocrusts ecosystem scale international society photogrammetry remote sensing inc isprs published elsevier rights reserved
road traffic noise widely studied environmental risk factor ischaemic heart disease myocardial infarction particular given myocardial infarction leading disability mortality cause bulgaria significant proportion urban population exposed high noise levels quantification burden disease attributable traffic noise essential environmental health policy making noise control engineering study aimed estimating burden myocardial infarction cases attributable road traffic noise bulgarian urban population used methodology estimating burden disease attributable environmental noise outlined world health organization risk data extracted recently published meta analysis providing updated exposureresponse relationship traffic noise risk myocardial infarction based data calculated fraction myocardial infarction cases attributable traffic noise loss quality adjusted life years qalys economic burden assuming sic per qaly myocardial infarction cases could attributed road traffic noise fifty five fatal nine hundred sixty eight qalys lost cases monetary value qalys sic million although measures used study crude give approximation real burden disease road traffic noise indicative important social economic aspect noise pollution bulgaria hopefully results direct attention epidemiologists environmental hygienists health economists pivotal environmental issue
entrepreneurial ecosystem literature attracted much attention especially policy circles however concept suffers number shortcomings lacks clear analytical framework makes explicit cause effect systemic concept yet fully exploited insights network theory always clear way proposed elements connected remains challenge institutions spatial scale impact structure performance studies often focused single regions clusters lack comparative multi scalar perspective literature tends provide static framework taking snapshot without considering systematically evolution time shortcomings make number suggestions take future research
adenosine dipyridamole myocardial perfusion imaging mpi stress agents literature supporting safety setting myocardial infarction regadenoson studying high risk cohort patients elevated cardiac biomarkers may shed light potential safety issues agents might also affect lower risk cohorts patients undergone clinically indicated stress mpi study two academic centers elevated troponin days prior testing included primary endpoint composite death non fatal congestive heart failure chf stroke ventricular arrhythmias atrial fibrillation flutter atrioventricular block requiring intervention within testing stress mpi studies met inclusion criteria underwent regadenoson dipyridamole adenosine dobutamine exercise stress respectively primary endpoint occurred patients incidence following regadenoson dipyridamole adenosine dobutamine exercise stress respectively adverse events included non fatal patients death patient chf patient ventricular arrhythmia patient atrial arrhythmia patient setting elevated troponin serious complications associated either exercise vasodilator stress testing appear relatively rare increased risk attributable particular vasodilator agent
background preclinical clinical evidence supports concept bidirectional brain gut microbiome interactions aimed determine subgroups irritable bowel syndrome ibs subjects identified based differences gut microbial composition correlations gut microbial measures structural brain signatures ibs methods behavioral measures stool samples structural brain images collected adult ibs healthy control subjects hcs ribosomal rna rrna gene sequencing used profile stool microbial communities various multivariate analysis approaches used quantitate microbial composition abundance diversity metagenomic content samples inferred rrna gene sequence data using phylogenetic investigation communities reconstruction unobserved states picrust weighted brain images acquired siemens allegra scanner morphological measures computed brain regions results using unweighted unifrac distances hierarchical clustering microbial data samples clustered two ibs subgroups within ibs population ibs like ibs hcs auroc sensitivity specificity random forest classifier provided support differentiation ibs groups microbes belonging genera faecalibacterium blautia bacteroides contributed subclassification clinical features distinguishing groups included history early life trauma duration symptoms greater ibs self reported bowel habits anxiety depression medication use gut microbial composition correlated structural measures brain regions including sensory salience related regions history early life trauma conclusions results confirm previous reports gut microbiome based ibs subgroups identify first time brain structural alterations associated subgroups provide preliminary evidence involvement specific microbes predicted metabolites correlations
purpose spite fact addictive potential benzodiazepine bdz drugs known long time benzodiazepine addiction remains common problem psychiatry deal etiology benzodiazepine addiction complex among risk factors course treatment demographic status psychological features patient seem play important role aim study investigate psychological genetic factors differentiating benzodiazepine addicts non addicted users method analysed cohort individuals treated benzodiazepines divided two groups benzodiazepine addicts non addicted benzodiazepine users control group groups measured genetic polymorphisms gaba maoa groups psychometric measurements performed investigated level depression anxiety state trait personality features dominant coping style using beck depression scale hamilton anxiety scale five factor personality inventory neo ffi coping inventory stressful situations results psychological situational risk factors benzodiazepine addiction high neuroticism introversion lack ability release tension interpersonal contacts dominance emotional coping style high accumulation critical life events childhood adulthood genetic background still remains field exploration conclusions genetic background bdz addiction remains field exploration
primary aims study examine prevalence personality disorders problem gamblers explore relationship personality disorders problem gambling severity explore degree psychological symptoms highlighted biosocial developmental model borderline personality disorder impulsivity distress tolerance substance use ptsd symptoms psychological distress work social adjustment associated problem gambling secondary aim explore strength relationships symptoms problem gambling severity problem gamblers without personality disorder pathology participants consecutively admitted problem gamblers seeking treatment specialist outpatient gambling service australia prevalence personality disorders using self report version iowa personality disorders screen cluster personality disorders cluster personality disorders associated problem gambling severity psychological symptoms except alcohol drug use significantly higher among participants personality disorder pathology compared without finally psychological distress work social adjustment significantly associated problem gambling severity problem gamblers personality disorder pathology impulsivity psychological distress work social adjustment significantly associated problem gambling severity without personality disorder pathology high rates comorbid personality disorders particularly cluster disorders necessitate routine screening gambling treatment services complex psychological profiles may complicate treatment problem gamblers comorbid personality disorders future research examine applicability biosocial developmental model problem gambling community studies
precise knowledge plant time constant essential perform thorough analysis design current control loop voltage source converters vscs perspective current controller dynamics low frequency range plant time constant also suitable cases lcl filter used loop behavior significantly influenced vsc working conditions effects associated converter losses included model equivalent series resistance addition plant inductance may also present important uncertainties respect value vsc lcl interface filter measured rated conditions thus paper method presented estimate parameters plant time constant equivalent inductance resistance plant model current controlled vscs proposed technique based evaluation closed loop transient responses axes synchronous reference frame proportional integral current controller implemented method gives set resistance inductance values employed rigorous design current controllers experimental results validate approach
design electromagnetic machine nonlinear multivariable multimodal optimization problem incurs great deal computation time calculating electromagnetic fields overcome problems effectively paper proposes new evolutionary multimodal optimization algorithm based big bang big crunch method aided surrogate model using theory compressed sensing efficiency demonstrated assessing optimization results test functions moreover evaluate feasibility application electromagnetic problem interior permanent magnet motor designed using proposed algorithm obtained results confirm proposed method ability search multiple optimal solutions good computational efficiency reducing number fitness function evaluations optimization process
photovoltaic energy natural form energy replace conventional fuels photovoltaic performance depends mainly incident solar irradiation temperature photovoltaic generator material composition article proposes method photovoltaic arrays modeling data provided manufacturer method finds electric equations current versus voltage power versus voltage photovoltaic array standard conditions model also takes account temperature insolation variations determine novel characteristics specific conditions article also discusses use converter realized means maximum power point tracker mppt control card obtains informations array microcontroller ports combined methods jump maximum power point mpp power comparison method used algorithm track maximum power point array analysis experimental results carried order verify proposed method another purpose article model optimal power using methodology experimental design optimization power delivered photovoltaic generator takes account insolation temperature factors general methods literature solar irradiation variations load variations considered results reflect conditions occur real conditions design experiment doe technique response surface methodology rsm employed analyze results tests obtained different climatic conditions results given analyzed article results used fit adjust response surfaces experimental data obtained results made possible propose mathematical model consequently study interactions temperature insolation doe simulation model implemented future works american institute chemical engineers environ prog
rationale pseudoprogression initial tumor growth followed subsequent tumor regression well described immunomodulation therapy melanoma patients phenomenon well defined lung cancer nivolumab anti monoclonal antibody recently approved nonsmall cell lung cancer nsclc second line therapy patient concerns diagnosis present patient squamous nsclc suffering multiple bone subcutaneous metastases interventions patient treated nivolumab outcomes subcutaneous lesion upper back grew substantially first cycle nivolumab later regressed marked improvement cancer sites lessons pseudoprogression may serve predict subsequent clinical response
saliency modeling played important part computer vision studies past years many state art models adopted complex mathematical machine learning theories paper simple effective visual attention model proposed find single fixed template enough saliency map generation idea inspired receptive field human visual system needed convolve input image template additional post processing experiments show model extremely fast performs better state art models human eye fixation prediction
recently photocatalytic hydrogen generation water semiconductor catalyst dispersion attracted world wide attention solar energy could converted directly hydrogen simple set scale scale although many photocatalysts reported active reaction efficiency still quite low work found hydrogen oxygen recombination took place rapidly tio dispersion resulted low hydrogen generation rate pure water activation energy recombination reaction mol regardless light irradiation case photocatalytic evolved could react rapidly evolved form eventually leading net evolution irradiation recombination hydrogen oxygen inhibited addition oxygen transfer reagent hemin chloride help photocatalytic generated oxygen captured transferred away photocatalyst surface backward reaction hydrogen oxygen recombination successfully restrained photocatalytic hydrogen evolution amount tio dispersion significantly enhanced condition isotopes analysis results confirmed water could recycled releasing gas bubbling could poisoned carbon monoxide lost oxygen transfer property therefore hydrogen could formed irradiation study clarified main impediment reason low efficient photocatalytic hydrogen generation semiconductor water dispersion present available method avoid negative reaction finding help design high active catalytic system solar energy hydrogen conversion open new window overall water splitting research elsevier rights reserved
asymmetric dopamine loss commonly found early parkinson disease effects functional networks difficult delineate patients variations age disease duration therapy used unilateral hydroxydopamine lesioned ohda rats controls treated single intraperitoneal injection levodopa dopa performing diffusion weighted mri resting state functional mri fmri accordance neurodegeneration nigrostriatal dopaminergic pathway diffusion tensor imaging showed increased radial diffusivity decreased fractional anisotropy lesioned substantia nigra likewise deterministic connectometry approach showed increase isotropic diffusion values medial forebrain bundle fmri showed reduced interhemispheric functional connectivity intact ohda lesioned caudate putamen unexpectedly increased ohda lesioned caudate putamen sensorimotor cortices hemispheres dopa reversed changes dopamine denervated caudate putamen sensorimotor cortices reduced interhemispheric caudate putamina similarly dopa induced fos expression sensorimotor cortices dopamine depleted caudate putamen taken together data suggest asymmetric degeneration nigrostriatal dopamine pathway results functional asynchrony intact ohda lesioned caudate putamen increased interhemispheric synchrony sensorimotor cortices results also indicate initial effect dopa restore functional corticostriatal connectivity rather synchronize caudate putamina author published elsevier inc
substantial evidence non major histocompatibility complex mhc genes associated spondyloarthritis spa studies mexican tunisian populations demonstrated association spa human leukocyte antigen hla purpose study evaluate association hla antigens group colombian patients diagnosis spa total patients healthy subjects included present study subjects underwent complete characterization hla alleles studied patients reactive arthritis rea ankylosing spondylitis undifferentiated spa uspa according assessment spondyloarthritis international society asas criteria axial spa axspa peripheral spa pspa men mean age years patients hla positive axspa patients hla positive uspa axspa pspa addition hla drb associated axspa also hla drb present patients axspa population found strong association presence hla diagnosis axspa hla also significantly associated subtypes disease predominantly pspa additionally hla associated cohort patients spa colombia
one fundamental requirements real time operating systems determinism executing critical tasks treating multiple periodic aperiodic events present paper presents hardware support nmpra processor multi pipeline register architecture dedicated treating time events interrupt events events associated synchronization inter task communication mechanisms real time systems treatment events important aspect paper describes mechanism implemented hardware prioritizing treating multiple events experimental results obtained using virtex fpga circuit article element originality short response time required treating prioritizing events
people inject drugs pwid mental health conditions major depression anxiety disorder antisocial borderline personality disorder may elevated risk hiv hcv infection study examined associations psychiatric disorders risky injection behavior treatment sample young pwid recruited participants outreach respondent driven sampling rds participants completed computer assisted self interview psychiatric interview interviews took place community based field site community outreach intervention projects participants young adults years injected drugs previous days psychiatric diagnoses based interviews using psychiatric research interview substance mental disorders prism injection behavior classified categories receptive syringe sharing equipment sharing sharing associations injection risk behavior psychiatric diagnoses tested using rds weighted multinomial regressions substance induced lifetime past year major depression borderline personality disorder significantly associated greater likelihood receptive syringe sharing substance induced major depression past year also associated nonsyringe equipment sharing primary major depression antisocial personality disorder anxiety disorders posttraumatic stress disorder slightly prevalent among injectors shared syringes however associations statistically significant substance induced major depression borderline personality disorder common among young pwid associated risky injection behavior
rainwater harvesting rwh systems united states vary terms design operation better understand common practices rwh community motivation collecting harvested rainwater electronic survey used poll members american rainwater catchment systems association arcsa two hundred twenty two members arcsa responded survey responses representative approximately rwh systems across united states respondents installed observed field survey questions focused system setup catchment materials roof cistern storage tank gutters downspouts motivation harvesting rainwater uses water treatment methods water quality testing practices results indicate composite asphalt shingles metal commonly used roofing materials rwh polyethylene common cistern material surveyed population commonly reported use harvested rainwater irrigation although greater respondents use rainwater potable purposes potable users greater utilize ultraviolet light primary treatment method approximately conduct water quality testing survey provides critical data current non potable potable rwh practices united states used guide future rwh research particular low frequency water quality testing efficacy treatment investigated number rwh systems installed united states elsewhere continues grow published elsevier ltd
mapping human genome important basis development new medicals medical treatments consequently attracted tremendous research funding last decade june materials genome initiative announced president obama collaboration modeling advanced materials databases unfortunately materials genome given rather vague definition announcement however materials genome defined analogy biological genomes one may conclude moment performance specific material depends chemical composition inherent property stored genome environment external interactions processing conditions usage materials genome thus defined set information encoded language thermodynamics obtained careful assessment experimental data quantum mechanical calculations certain conclusions material drawn calphad databases contain thermodynamic kinetic properties materials system databases allow prediction materials structure well response processing usage conditions major parts integrated computational materials engineering
modeling approach battery electrical energy storage system proposed paper model aims predict non linear power delivery dynamics given charge discharge demand controllable input normal operating range batteries also extreme cases battery charging order achieve model composed separated voltage current models several non linear models including hammerstein model non linear open circuit voltage characteristics takacs hysteresis model combined voltage current model respectively state charge battery also estimated recursive optimization fashion model parameterization estimation methods model described also demonstrated experimental data lithium iron phosphate lifepo cell experiment validation shows excellent agreement measured simulated voltage current signals provided model normal operating charging conditions contribution paper given unique combination data based models used capture linear dynamics static non linearity non linear hysteresis effects single dynamic voltage current model simulate predict non linear dynamic behavior battery energy storage delivery system elsevier ltd rights reserved
known objectiverhabdomyolysis severe potential adverse drug reaction statin therapy report case rhabdomyolysis due drug drug interaction ddi atorvastatin fluconazole review literature case summarya year old woman received atorvastatin hyperlipidaemia without problem years intravenous fluconazole added treating fungal infection rhabdomyolysis developed weeks later removal atorvastatin led resolution rhabdomyolysis new conclusionour case demonstrates subjects even moderate cypa inhibitor fluconazole may lead rhabdomyolysis subjects receiving statin characteristics reported cases rhabdomyolysis associated drug interaction statins fluconazole
objective review studies test treatments targeting adolescent suicidal ideation suicide attempts self harm make recommendations future intervention development method extant randomized clinical trials aim reduce intensity suicidal ideation recurrence suicide attempts self harm reviewed respect treatment components comparison treatments sample composition outcomes results majority studies showed effect suicidal ideation attempts self harm focus family interactions nonfamilial sources support two efficacious interventions also provided greatest number sessions treatment elements associated positive effects include addressing motivation treatment explicit plans integrating experimental treatment treatment usual many studies suicidal events tend occur early course treatment prior effective dose treatment could delivered important factors might mitigate suicidal risk sobriety healthy sleep promotion positive affect addressed studies conclusion interventions front load treatment shortly suicidal crisis example adolescent suicide attempters hospitalized may avert early suicidal events treatments focus augmentation protective factors parent support positive affect well promotion sobriety healthy sleep may beneficial regard prevention recurrent suicidal ideation attempts self harm adolescents
linear time invariant lti framework transformation input output equation state space representation well understood several canonical forms exist realise dynamic behaviour coefficients become time varying however lti transformation longer holds prove induction exists closed form expression observability canonical state space model using binomial coefficients
therapeutic supportive care interventions become increasingly effective growing numbers childhood adolescent cancer survivors face myriad physical psychological sequelae secondary disease treatment mental health issues particular present significant problem unique patient population depression affecting sizable number childhood adolescent cancer survivors multiple key determinants impact survivor risk developing depression variables traversing across biologic individual family community global levels well spanning throughout life course human development preconception prenatal periods adulthood multi level life course conceptual model offers valuable framework identify organize diverse variables modulate risk developing depression survivors childhood adolescent cancer review describes first multi level life course perspective applied development depression childhood adolescent cancer survivors conceptual framework may used guide investigation mental health interventions scacs ensure key determinants depression occurrence adequately addressed across various levels throughout life trajectory
nowadays online resources play important role teaching learning thanks new advances technology importance enhanced scientific areas even distance education universities classic hands laboratories always possible reason face face laboratory practices replaced even complemented online virtual remote laboratories vrl normally applications developed high level programming tools greater lesser extent use java unfortunately newly discovered java security issues impossibility run java smart devices restriction dissemination kind applications work first step towards get new structure easy java javascript simulations ejss allows remote connection hardware devices regard first objective solve problems java applications using ejss proposed solution provides user structure reuse vrls using java model runs server linked javascript graphical user interface client device ifac international federation antomatic control hosting elsevier ltd rights reserved
wastewater treatment processes activated sludge described specialized literature complex models nonlinear parameterization example activated sludge model asm asm asm conditions design control structures using state space representation difficult suitable techniques approach control processes using control structures based input output model using control structures obtained without even knowing process model paper two techniques type analyzed data driven technique virtual reference feedback tuning vrft robust control technique quantitative feedback theory qft control structures designed two methods implemented using wastewater treatment plant implemented simulation software simba complex influent considered influent includes information water temperature gives data period one year analysis two methods considers quality obtained control results time difficulty implementing two methods
purpose systematically review research concerning parent child agreement health related assessments reveal overall agreement directions agreement factors affect agreement ratings method uni search five additional databases searched children health issues grouped psychosocial issues including autism adhd physical performance issues including pain measures used comparison addressing psychosocial functioning physical performance functioning health related quality life results totally studies met inclusion criteria comprising analyses since four studies contained one analyses moderate child parent agreement demonstrated analyses poor agreement analyses several analyses found agreement observable external non observable internal domains overall parents considered children difficulties children although indications children physical performance issues parents may underreport children difficulties emotional functioning pain consistencies differences children parent ratings levels agreement respect children health issue age gender conclusions discrepancies child parent reports seem reflect different perspectives merely inaccuracy bias implications rehabilitation general parents consider children difficulties extensive difficulties children think perspectives child parents sought whenever possible since constitute important information concerning child health well children physical performance issues reported difficulties parents concerning children emotional functioning pain clinicians prioritize obtaining children views subjective aspects emotional issues well pain
modular exponentiation modular multiplications two fundamental operations various cryptographic applications hence performance public key cryptographic algorithms strongly influenced efficient implementation operations reducing frequency modular multiplications time requirements modular multiplication help developing efficient modular exponential algorithms work proposes energy efficient modular exponential algorithm based bit forwarding techniques particular two algorithms bit forwarding bit bfw bit forwarding bits bfw modifications existing binary exponential algorithm developed hardware realizations proposed algorithms evaluated terms throughput power energy results show increased throughput order reduction power energy saving order bfw bfw algorithms respectively xilinx ise virtex evaluation board icarus verilog simulation synthesis tool used hardware realization fpga synthesized using cadence asic elsevier rights reserved
study aimed explore association genetic polymorphism matrix metalloproteinase mmp transforming growth factor beta tgf beta susceptibility combined pulmonary fibrosis emphysema cpfe examined polymorphisms mmp tgf beta cpfe patients pulmonary emphysema patients idiopathic pulmonary fibrosis ipf patients frequencies polymorphic genotypes mmp cpfe group emphysema group ipf group highly statistically significant increased frequencies genotype allele cpfe emphysema groups compared ipf group frequencies polymorphic genotypes tgf beta cpfe group emphysema group ipf group significant increases genotype allele frequencies observed emphysema group compared ipf group study showed allele mmp allele tgf beta risk factors pulmonary emphysema allele mmp possibly predisposes patients pulmonary fibrosis develop emphysema kaohsiung medical university published elsevier taiwan llc
disruptive mood dysregulation disorder dmdd new controversial child psychiatric disorder characterized persistent irritability frequent temper loss among controversies surrounding dmdd whether age onset criterion dmdd may diagnosed age years justified study examined dmdd symptoms associated patterns psychiatric comorbidity behavioral family functioning sample preschoolers ages years admitted early childhood psychiatric day treatment program dmdd symptoms common acute clinical sample children presenting frequent temper outbursts chronic irritability compared children present dmdd symptoms children demonstrated aggression emotional reactivity lower receptive language skills high rates comorbidity disruptive behavior disorders findings contribute emerging literature preschool dmdd implications early childhood psychiatric assessment clinical interventions
purpose purpose paper investigate barriers pro social behaviour form blood donating using self determination theory design methodology approach respondents recruited intercepts major international university points within community capital city australia sampling conducted three week period resulting sample respondents findings results show intrinsic motivations positively influence intentions towards blood donation self identity locus control despite positively influencing factors external regulation positively influenced amotivation indicating likely people feel pressured donate blood less likely motivated donate blood originality value would suggest one way influence people become donors place greater focus positive emotional feelings derive act donating blood control donation using external regulation strategy often suggests people must donate blood may limiting blood donation numbers
adolescence potentially important time development emotion regulation parenting behaviors may play role examined associations among parenting behaviors parent resting heart rate variability adolescent resting heart rate variability parenting behaviors moderators association parent adolescent resting heart rate variability ninety seven youth years female african american euro american mixed ethnic background hispanic parents completed physiological assessment questionnaires assessing parenting behaviors inconsistent discipline corporal punishment negatively associated adolescent resting heart rate variability positive parenting parental involvement positively associated inconsistent discipline parental involvement moderated relationship parent adolescent resting heart rate variability findings provide evidence role parenting behaviors shaping development adolescent resting heart rate variability inconsistent discipline parental involvement potentially influencing entrainment resting heart rate variability parents children
thrombotic complications may occur patients essential thrombocythemia according cellular theory tissue factor activating extrinsic blood coagulation pathway essential activation blood clotting aim study evaluate activation dependent extrinsic pathway patients essential thrombocythemia depending presence absence janus kinase jak mutation study included newly diagnosed patients mean age years essential thrombocythemia tefferi vardiman leukemia patients diagnosed department clinical hematology hematological malignancies university hospital bydgoszcz poland control group consisted healthy volunteers mean age years concentration activity pathway inhibitor tfpi measured using elisa method patients essential thrombocythemia observed higher concentration median fold higher activity pmol compared control group also reported significantly higher activity tfpi compared control group moreover concentration tfpi significantly lower patients essential thrombocythemia jak mutation compared patients without mutation increased activity concentration responsible higher procoagulant potential patients essential thrombocythemia reduced activity tfpi patients essential thrombocythemia jak mutation indicates increased prothrombotic risk group patients
nonrelational distributed computing data warehouse analytics environment energy cradle developed analysis field laboratory data multiple heterogeneous photovoltaic test sites data informatics analytics infrastructure designed process diverse formats performance data climatic telemetry time series data collected outdoor test network solar durability lifetime extension global sunfarm network well point time laboratory spectral image measurements material samples using hadoop hbase distributed data warehouse energy cradle predefined data table schema enables ingestion data diverse changing formats easy data ingestion data retrieval energy cradle utilizes hadoop streaming enable python mapreduce provides graphical user interface cradle developing hadoop distributed computing platform hbase nosql database schema solar energy energy cradle exemplifies integrated scalable secure user friendly data informatics analytics system researchers example energy cradle enabled scalable data driven analytics presented machine learning used anomaly detection across million real world current voltage curves modules three distinct koppen geiger climatic zones
continuous monitoring engineering structures provides crucial alternative assess health condition well evaluate safety throughout whole service life link field measurements characteristics building one option characterize update model measured data best describe behavior performance structure paper present novel computational strategy bayesian probabilistic updating building models response functions extracted ambient noise measurements using seismic interferometry intrinsic building impulse response functions irfs extracted ambient excitation deconvolving motion recorded different floors respect measured ambient ground motion irf represents representative building response input delta function ground floor measurements firstly divided multiple windows deconvolution irfs window averaged represent overall building irfs hierarchical bayesian framework laplace priors proposed updating finite element model markov chain monte carlo technique adaptive random walk steps employed sample model parameters uncertainty quantification illustrative example studied validate effectiveness proposed algorithm temporal monitoring probabilistic model updating buildings structure considered paper storey concrete building instrumented accelerometers mit campus methodology described allows continuous temporal health monitoring robust model updating well post earthquake damage detection buildings elsevier ltd rights reserved
paper present multi proxy weak blind signature scheme based quantum entanglement swapping bell states scheme proxy signers finish signature instead original singer authority applied electronic voting system electronic paying system etc scheme uses physical characteristics quantum mechanics implement delegation signature verification could guarantee unconditionally security also anonymity message owner security analysis shows scheme satisfies security features multi proxy weak signature singers disavowal signature signature forged others message owner traced
cohort program increase retention represented groups chemistry developed college saint benedict saint john university particular program chose emphasize early career mentoring early access research goal chosen research repeatedly shown increase scientific identity resulting increased retention students stem fields several elements program useful preparing students access research programs early college careers including summer bridge program career mentoring advising second year research bootcamp course
self healing polymer coatings type smart material aimed advanced corrosion protection metals paper presents synthesis characterization two new cure self healing coatings based acrylated polycaprolactone polyurethanes macroscopic scale cured films show outstanding mechanical properties combining relatively high youngs modulus mpa strain break thermal activation strained films recover original length optical electron microscopy reveals self healing properties coatings hot dip galvanized steel scratches microindentations temperature induced closing defects restores corrosion protection barrier properties coating shown electrochemical impedance spectroscopy scanning vibrating electrode technique therefore coatings complementary option encapsulation based autonomous corrosion protection systems
known objectivethe role cypa drug metabolism receiving attention cypa may involved metabolism cypa substrates vivo previously thought polymorphism transporters glycoprotein breast cancer related protein bcrp influences metabolism substrates felodipine substrate aim study evaluate pharmacogenetic variability disposition felodipine healthy chinese subjects methodsa single dose felodipine orally administered healthy chinese subjects serum concentration felodipine measured using detected snps cytochromes enzymes transporters play vital roles drug metabolism high frequency mutation chinese population results discussionthe area plasma concentration time curve auc within time points auc felodipine administration significantly higher subjects possessing bcrpaa alleles bcrp genotype subjects cypa higher felodipine exposure cypa new conclusionthis study showed genetic polymorphisms cypa bcrpca might explain variability pharmacokinetics felodipine chinese population
asphalt shingle roofing performed specialty contractors construction industry roofing crew performing tasks different areas roof simultaneously asphalt shingle roofing materials improved roofing construction process changed significantly past years paper describes process factors affect productivity workers methods calculating productivity terms man hours worked cost per unit output safety also concern roofing falls roofs major cause injuries construction job site injuries common roofers include sprains strains back knees ankles trend constructing steep roofs common texas high end residential homes implicated injuries safety plans worker safety climate low priorities financially strapped construction companies designing hazard would effective personal protective equipment ppe preventing accidents roofing industry paper concludes research development needed improve roofing construction methods provide safe healthy environment worker reduce costs construction published elsevier ltd
study effect oxalic acid treatment artichoke plants cynara scolymus head artichoke development artichokes quality parameters weight loss firmness color respiration rate antioxidant activity phenolics measured folin ciocalteu hplc dad esi msn harvest storage days degrees evaluated treatment increased percentage first class artichokes although significant effect found artichoke developmental process treatment reduced respiration rate artichokes led higher total hydrosoluble antioxidant activity total phenolics hydroxycinnamics luteolins concentration harvest cold storage addition luteolin glucuronide glucoside identified first time artichoke thus concluded preharvest treatment could natural useful tool delay artichoke postharvest senescence improve reported health beneficial properties artichokes consumption elsevier ltd rights reserved
osteoporosis major problem elderly population worldwide low calcium intake vitamin blood level risk factors osteoporosis improving intake effective patients micronutrients deficiency however effect interventions ambiguous additive formula diet afd contains fructo oligosaccharide fos isofiavone iso citric acid supplement patients osteoporosis aimed investigate effect afd bone structure femur ovariectomized rats sixteen week old ovariectomized rats randomly distributed groups one group fed normal diet second group fed afd groups fed weeks body weight measured weeks measuring weight weeks rats euthanized using carbon dioxide lateral femur bone extracted bone mineral density bmd bone mineral content bmc measured via micro computed tomography non decalcified ground sections femur examined via polarized light microscopy weeks bmd bmc significantly higher group group group showed significantly better structural values respect spac smi group group showed significantly denser trabecular observations group examination non decalcified ground section group showed strong polarized light properties orange compared sections group afd may improve bone turnover osteoporosis expectant decrease incidence falls bone fractures may enhance quality life elderly
objectivewe recently established novel method evaluate emulsion stability pharmaceutical skin cream key technology method magnetic resonance imaging mri purpose study verify usefulness method cosmetic industry methodsmilky lotion type emulsions employed test samples note test samples prepared taking account commercial milky lotions sample preparation centrifugation treatment min implemented accelerate destabilization processes centrifuged samples monitored using relaxation time maps furthermore histograms generated maps analysed investigate destabilization process detail addition small fractions upper lower phases collected centrifuged samples microscopic observations conducted resultst maps successfully visualized destabilization process accompanying centrifugation protocol microscopic observations clarified main mechanism destabilization process creaming sensitivity map creaming much superior visible observation map detect slight creaming visible naked eye addition map also enables detection slight reversible creaming dispersion changes accompanied repeated centrifugation vortexing treatment using parameters derived histogram analysis creaming behaviour evaluated precisely objectively study prepared emulsions containing different thickener contents compared creaming behaviours consequence analysis could fully evaluate effect thickener emulsion stability evaluation method conclusionmri promising tool evaluation stability cosmetic emulsions resume objectifnous avons recemment developpe une nouvelle methode pour evaluer stabilite emulsion cremes pharmaceutiques pour peau technologie cle procede est imagerie par resonance magnetique irm cette etude est verifier utilite procede dans industrie cosmetique methodesdes emulsions type lotion laiteuse ont ete utilisees comme echantillons essai nous notons que les echantillons essai ont ete prepares tenant compte des lotions laiteuses commerciales apres preparation echantillon traitement centrifugation jusqu min ete effectue pour accelerer leur processus destabilisation les echantillons centrifuges ont ete controles utilisant des cartes temps relaxation outre les histogrammes generes par les cartes ont ete analyses pour etudier processus destabilisation dans detail plus petites fractions des phases superieures inferieures ont ete recueillies partir des echantillons centrifuges des observations microscopiques ont ete realisees resultatsles cartes visualisaient avec succes processus destabilisation accompagnant protocole centrifugation apres les observations microscopiques etait clair que principal mecanisme processus destabilisation ete ecremage sensibilite carte ecremage etait bien superieure celle observation visible carte peut detecter leger ecremage qui est pas visible oeil plus les cartes permettent detection legers changements reversibles ecremage dispersion accompagnes par traitement repete centrifugation vortex utilisant les parametres issus analyse histogramme comportement ecremage peut etre evalue maniere plus precise plus objective cette etude prepare des emulsions contenant differentes teneurs epaississant puis compare leurs comportements ecremage consequence cette analyse nous pourrions evaluer pleinement effet epaississant sur stabilite emulsion par methode evaluation conclusionl irm est outil prometteur pour evaluation stabilite des emulsions cosmetiques
objective growing number patients require revisional procedure due inadequate weight loss primary bariatric surgery psychological factors eating disorder frequently blamed responsible poor weight loss results primary revisional surgery aim study determine whether preoperative psychological factors personality disorders pds eating behaviors revisional surgery candidates differ primary bariatric surgery candidates methods november june candidates bariatric surgery extensive psychological assessment included study patients evaluated using different autoquestionnaires assess psychological factors item short beck depression inventory hospital anxiety depression scale cohen perceived stress scale rathus assertiveness schedule rosenberg self esteem scale eating behaviors bulimic investigatory test edinburgh yale food addiction scale scid data compared groups primary revisional procedures results eighty nine subjects candidates primary bariatric surgery subjects revisional procedure due insufficient weight loss preoperative psychological factors also eating behaviors differ significantly primary revisional surgery candidates borderline personality disorder bdl appeared twice frequent revisional surgery candidates respectively discussion unexpectedly found eating habits make difference looking bdl disorders especially impulsivity personality traits seems relevant appears special trait candidates revisional procedure could compromise weight loss
detection model set models best describes behavior system primary importance many applications article two discriminating signals derived measurements plant switches two model behaviors transfer functions inputs two signals identical one model effective negative model effective developed detection algorithm called innovation squared mismatch utilized read operation probe based data storage innovations squared mismatch method offers better detection performance significantly less computational complexity compared prevalently used maximum posteriori probability based methods current data storage systems article proposes employing maximum likelihood sequence detection based methods plant behavior switch one model another high rates transients previous behavior affect current behavior causing inter symbol interference exhaustive simulation experimental results corroborate efficiency proposed methods elsevier ltd rights reserved
previously demonstrated statistically distinct factors degeneration alzheimer disease one strongly related white matter damage age interpreted age vascular related related cortical atrophy thought represent neurodegenerative changes associated alzheimer disease factors replicated distinct cross sectional data set participants alzheimer disease neuroimaging initiative interpretation improved using correlations csf biomarkers furthermore show changes factors years independently associated decline miniemental state examination score longitudinal subset individuals mild cognitive impairment progression age vascularrelated factor greater individuals apoe epsilon alleles linked greater attributable change miniemental state examination neurodegenerative factor results suggest benefits targeting white matter vascular health complement interventions focused neurodegenerative aspect disease even individuals little discernable vascular comorbidity elsevier inc rights reserved
sms widely used technology globally may also improve art adherence yet sms notifications social supporters following real time detection missed doses showed clear benefit recent pilot trial examine demographic social cultural dynamics may explain finding trial hiv positive individuals initiating art received real time adherence monitor randomized two types sms reminder interventions versus control sms sms notifications also sent patient identified social supporters sustained adherence lapses like participants social supporters interviewed enrollment following matched participant adherence lapse exit social supporters regular income significantly associated fewer adherence lapses instrumental support associated fewer adherence lapses among social supporters food secure qualitative interview data revealed diverse complex economic relationship dynamics affecting social support resource availability emotionally positive relationships seemingly facilitated helpful support limited resources prevented active provision support many effective social support appeared subject social supporters food security economic stability well functioning social network dependent trust supportive disclosure
atrial fibrillation commonest sustained cardiac arrhythmia strongly associated conditions valvular heart disease coronary artery disease particularly hypertension diabetes mellitus south asian ethnic group high rates conditions would expected significant risk however observational studies consistently shown south asians lower prevalence compared caucasians article summarizes current evidence surrounding development relationship ethnicity offers potential reasons disparity identifies future areas research
regression analysis using orthogonal polynomials time domain used derive digital filter infinite impulse response satisfies maximally flat design constraints near low frequency phase high frequency gain may adjusted lead lag compensation plant dynamics simulated design examples used show compensating filter may intuitively tuned desired closed loop response shown second order instantiation compensating filter reduces proportional differential plus filter controller improved noise attenuation closed form expressions filter coefficients function two design parameters provided
goals therapy patients polycythemia vera improve disease related symptoms prevent incidence recurrence thrombosis possibly delay prevent transformation myelofibrosis acute myeloid leukemia aml cytoreductive therapies used older patients history thrombosis achieve goals hydroxyurea remains first line cytoreductive choice however one four patients treated time develop resistance intolerance importantly patients fail fold increase mortality fold increase risk transformation myelofibrosis aml therefore alternative therapies needed patients interferon alpha used shown significant activity achieving hematologic responses decreasing jak mutation allele burden jak inhibition also investigated recently garnered regulatory approval indication review discuss current treatment options available patients novel therapies currently investigation
number studies reported dysfunctions steroid secretion including altered cortisol testosterone levels borderline personality disorder bdp patients compared healthy controls present study extends findings blood saliva studies cumulative measure hair steroids investigated women bpd age education matched healthy women find differences bpd patients healthy women concerning hair cortisol levels increased hair testosterone levels among bpd patients compared controls results remained restricting analyses unmedicated patients data indicate altered long term testosterone cortisol levels females bpd future studies address possible impact altered testosterone medical illness processes including metabolic syndrome population elsevier ltd rights reserved
recent decades growing attention toward using teamwork commitment productivity teams improve quality education research higher education institutes achieve goals leadership style team leaders group organizational citizenship behavior gocb team members exceed formal roles high importance article explores effects shared leadership group commitment productivity university teams also investigates whether gocb mediates effect shared leadership team commitment productivity structural equation modeling sem smartpls software applied investigate relationship variables results show shared leadership direct indirect gocb effects team commitment productivity shared leadership affects gocb team commitment team productivity furthermore gocb affects team commitment team productivity
purpose evaluate impact adjuvant radioactive iodine therapy rai prognosis assessed progression free survival pfs overall survival patients affected differentiated thyroid carcinoma dtc lymph node relapse previously treated lymphadenectomy retrospectively evaluated dtc patients treated lymph node dissection disease relapse patients previously undergone total thyroidectomy radioiodine remnant ablation rra used clinical histological data obtained follow assess response outcome means univariate multivariate time event analyses assessed impact rai outcome pfs prognostic role thyroglobulin levels suppression levothyroxine measured months lymphadenectomy risk factors evaluated patients age diagnosis median years interquartile range treated rai median follow time years patients showed disease progression died kaplan meier pfs curves showed age diagnosis tumor histology tumor size dtc aggressive variant associated prognosis patients treated rai showed better pfs log rank untreated patients effect rai observed patients multivariate models showed age rai yes remained independent factors associated pfs age remained significantly associated nonetheless patients treated rai showed lower risk mortality untreated patients rai lymphadenectomy dtc relapse significantly associated better pfs patients
malformation sheet metal tapping screw threads screw threading process increases cost screw threading dies maintenance die factories reveal screw threading die design techniques production maintenance processes established trial error worker experience passing techniques documenting quality control difficult study screw thread forming design process analysis carried combining computer aided design software computer aided metal forming analysis software simulation results verified actual forming process sheet metal tapping screw forging size error less except sharp angle associated error thereby demonstrating accuracy simulated forming process numerical analysis process utilized shorten forming development time reduce number die tests improve product quality die service life reducing cost development promoting overall competitiveness company
background thyroid function tests one commonly undertaken investigations paediatric outpatient department based existing literature standard guidelines respect sampling procedure followed infants children every paediatrician aware logistic problems taking fasting sample infants younger children unlike adults context planned undertake pilot study identify timing sampling fasting postprandial status makes difference respect thyroid function tests children materials methods descriptive study undertaken paediatric unit chengalpattu medical college evaluate difference fasting postprandial blood levels thyroid stimulating hormone free children study approved institutional ethical committee informed written consent assent obtained prior study fifty one children years age recruited based willingness endocrine clinic paediatric outpatient clinic fasting postprandial blood samples collected venepuncture respectively blood samples analysed using electrochemiluminescence method data analysis done using epi info software results children underwent fasting postprandial sampling thyroid evaluation results reveal statistically significant difference fasting postprandial samples tsh free true hypothyroid euthyroid children subclinical hypothyroidism encountered one child fasting sample conclusion pilot study revealed postprandial tsh free used reliable test thyroid evaluation fasting sample children
reliable detection attribution changes vegetation greenness prerequisite development strategies sustainable management ecosystems conducted robust trend analysis remote sensing derived vegetation index time series matrices detect significant changes inter annual vegetation productivity greening versus browning entire himalaya biodiverse ecologically sensitive yet understudied region spatial variability trend assessed considering elevation dominant land cover use types ecoregions assess trend causation local scale compared multi temporal imagery regional scale referenced ecological theories mountain vegetation dynamics ancillary literature overall himalayan vegetation exhibited significant trend eastern high himalaya browning dominantly western high himalaya land cover use based categorization confirmed dominant greening rainfed irrigated agricultural areas though cropped areas western himalaya contained higher proportion greening areas rising atmospheric concentration nitrogen deposition likely climatic causes detected greening success sustainable forestry practices community forestry nepal along increasing agricultural fertilization irrigation facilities could possible human drivers comparison multi temporal imagery enabled direct attribution browning areas anthropogenic land change dam airport tunnel construction satellite detected browning high altitude vegetation eastern himalaya confirm findings recent dendrochronology based studies possibly resulted reduced pre monsoon moisture availability recent decades results significant implications environmental management context climate change ecosystem dynamics himalaya elsevier rights reserved
paper presents semi empirical relationship coherence time ocean reflected digital satellite radio signals significant wave height swh experiment conducted platform harvest petrochemical exploration platform located pacific ocean coast southern california raw data recorded directly received ocean reflected signals xmradio bandwith center frequency ghz directv band center frequency ghz antennas located approximate altitude meters ocean surface using technique first developed global navigation satellite systems gnss signals coherence time interferometric complex field icf computed cross correlating direct reflected signals relationship developed icf swh done first developing model showing relationship icf correlation time sea surface swh monte carlo simulation ocean surface used show empirical relationship correlation time sea surface swh takes quadratic form coefficients empirical model finally determined fitting experimental data band signals limited amount band signals radio directv transmission respectively retrievals swh experimental data inverting relationship compared situ recordings nearest buoy away band measurements found standard deviation meters range swh meters
growth healthcare needs challenges providers reduce operational costs expected increase construction renovation healthcare facilities meanwhile concerns regarding environmental impacts hospitals made healthcare sector one prominent settings green building movement despite environmental concerns number studies document benefits sustainable healthcare facilities limited study authors used national cost report data centers medicare medicaid services developed benchmarking tool comparing operation maintenance costs healthcare facilities peers authors used longitudinal data compared annual operation maintenance cost leadership energy environmental design leed hospitals median cost non leed facilities comparable type ownership location analysis failed provide evidence achieving leed credits leed certification general lowers operation maintenance costs healthcare facilities authors published elsevier ltd
using continuous flash suppression cfs demonstrated four experiments affective information extracted unseen faces influences affective personality judgments neutral faces four experiments participants judged neutral faces pleasant unpleasant studies less trustworthy likable attractive study less competent interpersonally warm study paired unseen smiling scowling faces compared paired unseen neutral faces findings suggest affective influences normal part everyday experience provide evidence affective foundations consciousness affective misattribution arises even affective changes occur neutral stimulus presented demonstrating affective influences explained simple semantic priming effect findings implications understanding constructive nature experience well role affect social impressions
backgroundfriends important childhood adolescence especially bullied children technology mediated communication tmc could used develop maintain friendship present study examined trends use tmc friends possible differences bullied bullied children differences children close friends children several close friends methodsdata obtained three waves serial cross sectional health behaviour school aged children survey conducted denmark finland iceland sweden total sample consisted children aged resultstwo trends observed first trend showed increased use tmc countries children bullied several close friends increased use tmc friends second trend applicable bullied children close friends children increased use tmc thus remained levels conclusionsbullied children close friends excluded communication forums usually allow children maintain develop friendships concern friends important childhood adolescence especially bullied children
objectives investigate association physical fitness obesity health related quality life hrqol sleep disturbance community dwelling older spanish women years age study design cross sectional study method sleep disturbance assessed jenkins sleep scale active sedentary behaviors recorded standardized questionnaires hrqol assessed euroqol anthropometric measurements obtained using standardized techniques body fat measured using bioelectrical impedance physical fitness evaluated set eight tests results sleep disturbance reported women associated higher body mass index waist circumference presence insomnia inversely associated physical fitness women upper tertile fitness index lower risk sleep disturbance compared lower tertile women highest tertile upper body strength lower risk sleep disturbance compared lower tertile women without sleep disturbance showed better hrqol conclusion sleep disturbance associated central obesity lower physical fitness reduced hrqol interventions involving weight management improvement physical fitness may contribute better sleep quality older women
new design method stable dynamic output feedback dof controller linear mimo systems presented frame real grassmann spaces analysis dof systems decomposed augmented static output feedback sof systems using signal flow graph analysis dof loops synthesis design characteristic polynomial augmented sof system system stable poles sub characteristic polynomial sub sof system controller stable poles parametrized within grassmann invariants real grassmann spaces whose coordinates defined real coefficient function spaces augmented sof variables numerical parametrization computation algorithm stable controller design illustrated mimo plant practical aircraft carrier model
human activity recognition key task ambient intelligence applications achieve proper ambient assisted living remarkable progress domain challenges still remain obtain robust methods goal work provide system allows modeling recognition set complex activities real life scenarios involving interaction environment proposed framework hybrid model comprises two main modules low level sub activity recognizer based data driven methods high level activity recognizer implemented fuzzy ontology include semantic interpretation actions performed users fuzzy ontology fed sub activities recognized low level data driven component provides fuzzy ontological reasoning recognize activities influence environment semantics additional benefit approach ability handle vagueness uncertainty knowledge based module substantially outperforms treatment incomplete imprecise data respect classic crisp ontologies validate advantages public cad dataset cornell activity dataset achieving accuracy low level high level activities respectively entails improvement fully data driven ontology based approaches
multiple avenues research criminal careers intergenerational family transmission epidemiological studies indicated concentration antisocial traits behaviors cluster among families within individuals population current study draws perspectives exploring intergenerational contours antisocial personality disorder across multiple generations large scale epidemiological sample analytic sample persons meeting criteria antisocial personality disorder derived waves national epidemiologic survey alcohol related conditions path analytic latent class multinomial models executed describe elucidate family histories among persons diagnosed antisocial personality disorder three classes antisocial family tree found minimal family history problem behaviors sample characterized higher socioeconomic functioning parental progeny behavior problems sample characterized criminal behaviors psychopathology substance use disorders multigenerational history problem behaviors sample characterized alcoholism psychopathology versatile criminal offending findings add typology intergenerational studies antisocial behavior assist identifying etiological treatment factors among crime runs family
intergroup contact theory empirically supported variety social contexts samples drawn rapidly developing nations undergoing severe political sociocultural conflict using caucasus barometer data three nations south caucasus armenia azerbaijan georgia test effect interreligious contact various forms group resistance region world historically presently marked severe religious ethnic conflict additionally take account self selection effects using propensity score matching results overwhelmingly support intergroup contact theory three countries objections toward intermarriage still remain high treated groups addition exist significant differences based group studied contact effects strongest groups posing little religio cultural organized threat weaker contact effects though appear less related threat contextual group specific elsevier inc rights reserved
background aloe vera traditional medical plant whose gel widely used skin care previously identified aloe sterols aloe vera active ingredients study investigated protective effects aloe sterols without polysaccharides ultraviolet uvb induced skin pho toaging mice using aloe vera gel extract avge obtained supercritical fluid extraction methods aloe vera gel extract supplemented diet ppm hairless mice exposed uvb irradiation weeks skin measurements histological analytical studies performed results repeated uvb irradiation induced rough wrinkling skin water content reduction hyperkeratosis avge administration resulted significant improvement uvb induced skin dryness epidermal thickness wrinkle formation avge group also suppressed degenerations dermal collagen fibers appearance cutaneous apoptosis cells induced uvb furthermore avge administration reduced excess elevation pro inflammatory cytokines beta tnf alpha matrix metalloproteinases mmp mmp mmp mmp uvb exposed skin conclusion dietary ingestion aloe sterols protected chronic uvb damage mouse skin results suggest aloe sterols may prevent skin photoaging anti inflammation mmp regulation
study examines appearance self modulation nonlinear electrical circuits presenting jump resonance phenomenon variable inertial damping oscillations envelope slow forced oscillation periodic non periodic character determined environmental influence damping factor results experimental study obtained numerical simulation experiment confirm initial theoretical considerations copyright john wiley sons ltd
hydroxy methylglutaryl coa reductase hmgr considered first rate limiting enzyme plant isoprenoid biosynthesis discovered mdhmgr gene malus domestica showed amino acid sequence identity mdhmgr mdhmgr showed root specific expression pattern apple strongly enhanced eth meja mdhmgr expressed constitutive manner sensitive hormone treatments mdhmgr mdhmgr promoters cloned sequenced analyzed using bioinformatics tools promoter sequence homology various potential cis acting elements responsive hormones present gus activity driven full length mdhmgr mdhmgr promoters observed transgenic arabidopsis plants carrying full mdhmgr promoter exhibited strong gus expression seedlings leaves stems flowers significant gus activity driven full mdhmgr promoter found roots mdhmgr promoter constitutive promoter mdhmgr promoter root specific promoter deletion analysis based agrobacterium mediated transient assays arabidopsis seedlings indicated mdhmgr promoter region could maintain basic promoter activity root specific expression
cellular learning automata cla distributed computational model introduced last decade model combines computational power cellular automata learning power learning automata cellular learning automata composed lattice cells working together accomplish computational task cell equipped learning automata wide range applications utilizes cla image processing wireless networks evolutionary computation cellular networks however input model reinforcement signal receive another input state environment paper introduce new model cla cell receives extra information environment addition reinforcement signal ability getting extra input environment increases computational power flexibility model designed new algorithms solving famous problems pattern recognition machine learning classification clustering image segmentation based proposed cla investigated performance algorithms several computer simulations results new clustering algorithm shows acceptable performance various data sets cla based classification algorithm gets average precision eight data sets comparison svm knn naive bayes average precision respectively similar results obtained semi supervised classification based proposed cla elsevier rights reserved
online consultation increasingly offered parenting practitioners clear feasible provide empowerment oriented support single session email consultation based empowerment theory developed guiding empowerment process model gep model evaluate text based consultation content analysis email advice sentences total investigated feasibility newly developed model inter observer agreement internal consistency factor structure validity concurrent validity evaluated comparing coding results using gep model social support model partially intersects empowerment results showed good inter observer reliability internal consistency gep model results provided evidence concurrent validity significant correlation coding results gep model social support model although also distinctive described techniques practitioners may employ guide parental process towards empowerment observed sample also guidance provided components empowerment process feasibility gep model content analysis email consultation parental support theoretical empowerment perspective demonstrated
study aimed verify whether prolonged exposure low level mercury promotes haemodynamic disorders studied reversibility vascular damage rats divided seven groups three control groups received saline solution days two groups received hgcl first dose subsequent doses day days two groups received hgcl days doses followed day washout period systolic blood pressure sbp measured along analysis vascular response acetylcholine ach phenylephrine phe absence presence endothelium nitric oxide synthase inhibitor nadph oxidase inhibitor superoxide dismutase nonselective cyclooxygenase cox inhibitor receptor blocker reactive oxygen species ros levels antioxidant power measured plasma hgcl exposure days reduced endothelium dependent relaxation increased phe induced contraction contribution ros cox derived vasoconstrictor prostanoids angiotensin acting ati receptors response participation reduced increased oxidative stress plasma increased sbp days exposure cessation hgcl exposure sbp endothelium dependent relaxation phe induced contraction oxidative stress normalised despite persistence increased cox derived prostanoids results demonstrated long term hgcl exposure increases sbp consequence vascular dysfunction however hgcl removal environment vascular function ameliorates
widely used mobile operating systems single vulnerability threaten security privacy billions users therefore identifying vulnerabilities fortifying software systems requires constant attention effort however costly almost impossible analyse entire code base thus necessary prioritize efforts towards likely vulnerable areas first step identifying areas profile vulnerabilities based previously reported ones investigate performed manual analysis android vulnerabilities reported national vulnerability database period analysis identified comprehensive list issues leading android vulnerabilities also point characteristics locations vulnerabilities reside complexity locations complexity fix vulnerabilities enable future research make available data
studies general population indicate involvement correctional system strongly associated risk contracting hiv sexually transmitted infections however limited studies examined offender status hiv risk among african americansa population disproportionately impacted incarceration hivand even fewer examined risks among african american church affiliated populations study examined offender status hiv risks perceptions church involvement hiv prevention strategies among participants affiliated african american churches findings indicate offender participants likely tested hiv believed church involved hiv prevention strategies future research practice recommendations design culturally religiously tailored interventions offender hiv prevention screening linkage care african american church settings discussed
fast developing world today inevident demand good quality power supply essential present day power systems possess efficient control algorithms load frequency control although recent years lot research carried direction however parametric uncertainty rejection external disturbances continue remain important issues lfc design engineers control algorithms based fractional order control known possess excellent disturbance rejection capability well high robustness towards system parameter variations higher level robustness incorporated system using interval model plant designing controller therefore paper fractional order pid controller designed interval model single area load frequency control using kharitonov theorem technique gives freedom design engineer decide limits parameter variations controller required perform well helps improving system performance well overall safety system preventing system breakdown may occur due sudden increase system parameter finally performance proposed controller compared nominal controllers existing literature evaluated basis various integral error criterion observed proposed controller gives best performance capable stabilizing system larger range system parameter variations elsevier ltd rights reserved
statistical analysis massive complex data sets require development algorithms depend distributed computing collaborative inference inspired propose collaborative framework aims estimate unknown mean theta random variable model present certain number calculation units distributed across communication network represented graph participate estimation theta sequentially receiving independent data exchanging messages via stochastic matrix defined graph give precise conditions matrix statistical precision individual units comparable gold standard virtual centralized estimate even though unit access data show particular fundamental role played non trivial eigenvalues ramanujan class expander graphs provide remarkable performance moderate algorithmic cost
consider optimal distributed computation given function distributed data input data nodes sink node receives function form connected network described undirected weighted network graph algorithm compute given function described weighted directed acyclic graph called computation graph embedding defines computation communication sequence obtains function sink two kinds optimal embeddings sought embedding minimizes delay obtaining function sink minimizes cost one instance computation function abstraction motivated three applications network computation sensor networks operator placement distributed databases module placement distributed computing first show obtaining minimum delay minimum cost embeddings complete problems cost minimization actually max snp hard next consider specific forms computation graph polynomial time solutions possible computation graph tree polynomial time algorithm obtain minimum delay embedding described next case function described layered graph describe algorithm obtains minimum cost embedding polynomial time algorithm also used obtain approximation delay minimization consider bounded treewidth computation graphs give algorithm obtain minimum cost embedding polynomial time
rationale maintenance surface immune barrier important homeostasis organs mucosal surfaces interface external environment however role mucosal immune system chronic lung diseases incompletely understood objectives examined relationship secretory iga siga mucosal surface small airways parameters inflammation airway wall remodeling chronic obstructive pulmonary disease copd methods studied small airways diameter former smokers copd control subjects small airways identified serial tissue sections examined epithelial morphology siga bacterial dna nuclear factor kappa activation neutrophil macrophage infiltration airway wall thickness measurements main results morphometric evaluation small airways revealed increased mean airway wall thickness inflammatory cell counts lungs patients copd compared control subjects whereas siga level mucosal surface decreased however small airways classified siga intact siga deficient found pathologic changes localized almost exclusively siga deficient airways regardless study group siga deficient airways characterized abnormal epithelial morphology invasion bacteria across apical epithelial barrier nuclear factor kappa activation accumulation macrophages neutrophils fibrotic remodeling airway wall conclusions findings support concept localized acquired siga deficiency individual small airways patients copd allows colonizing bacteria cross epithelial barrier drive persistent inflammation airway wall remodeling even smoking cessation
lipid bilayer membranes extensively studied coarse grained molecular dynamics simulations numerical efficiencies reported cases aggressive coarse graining several lipids coarse grained particle size similar one particle thickness direction yuan proposed pair potential one particle thick coarse grained lipid particles capture mechanical properties lipid bilayer membrane gel fluid gas phase transitions lipids diffusion bending rigidity yuan work implement interaction potential lammps simulate large scale lipid systems giant unilamellar vesicle guv red blood cells rbc also consider effect cytoskeleton lipid membrane dynamics model rbc dynamics incorporate coarse grained water molecules account hydrodynamic interactions interaction coarse grained water molecules explicit solvent molecules modeled lennard jones potential demonstrate proposed methods capture observed dynamics vesicles rbcs focus two sets lammps simulations vesicle shape transitions enclosed volume rbc shape transitions different enclosed volume finally utilizing parallel computing capability lammps provide timing results parallel coarse grained simulations illustrate possible use lammps simulate large scale realistic complex biological membranes program summary program title fluidmembrane program files doi http dolorg vnkvhc licensing provisions gnu gplv programming language nature problem pair potential function simulating shape transition fluid vesicles resting shapes red blood cells program solution method nose hoover thermostat berendsen pressure coupling algorithms external routines libraries lammps subprograms used create rbc water matlab bond harmonicl example lammps input script elsevier rights reserved
circulating endothelial progenitor cells epcs bone marrow derived stem cells able migrate sites damaged endothelium differentiate endothelial cells altered epc level function described various inflammatory diseases shown augment vasculogenesis murine models previous studies epc context crohn disease yielded conflicting results determine whether circulating levels epcs changed context patients healthy controls recruited disease activity assessed cdai peripheral blood mononuclear cells isolated epc numbers evaluated facs analysis using anti anti vegf receptor anti anti markers eighty three subjects including patients controls recruited including males aged years cases controls respectively mean cdai disease duration years receiving biologics mean duration months mean level peripheral epcs patients percent controls significant correlation epc levels age cdai disease duration duration treatment biologics epcs elevated patients studies needed examine function epcs possible role marker disease severity therapeutic response
paper proposes new method decoupling subdividing electrical circuits containing power electronics devices order achieve fast accurate real time simulation technique state variable discretized using different discretization methods combining implicit explicit ode solvers state space equations decoupled remaining accurate stable unlike traditional decoupling techniques previously proposed proposed one require artificial delay supplementary states added order decouple system furthermore technique meant implemented commercially available simulation software large complex circuit containing several hundreds state variables easily accurately simulated minor modification existing models finally stability accuracy proposed technique thoroughly demonstrated numerical example steady state faulty conditions
knowledge internal stability granular soils key factor design granular geotextile filters evaluate internal stability granular soils different semi empirical methods generally used nevertheless results methods soil lead different internal stability evaluations paper evaluate reliability semi empirical methods available literature internal stability different granular soils reconstituted authors researchers studied means theoretical experimental approaches particular theoretical analysis internal stability performed using simulfiltr method developed recently authors experimental evaluation internal stability carried means long term filtration tests comparison internal stability analysis performed means semi empirical theoretical experimental methods showed semi empirical methods always reliable therefore base results new chart terms minimum slope min grain size distribution average value finer percentage proposed evaluate internal stability granular soils
spite modern treatment acute myocardial infarction ami still carries significant morbidity mortality worldwide even though standard care therapy proves symptoms also long term prognosis patients ami solve critical issue specifically permanent damage cardiomyocytes result complex process occurs namely cardiac remodeling leads alterations cardiac size shape function driven quest unconventional therapeutic strategies aiming regenerate injured cardiac vascular tissue one latest breakthroughs regard stem cell therapy based favorable data obtained experimental studies therapeutic effectiveness innovative therapy investigated clinical settings various cell types used clinic autologous bone marrow derived scs first used treat ami patient years ago since witnessed increasing body data regards cutting edge therapy although feasibility safety transplant clearly proved efficacy still dispute conducted studies meta analysis reported conflicting results hope conclusive answer provided largest ongoing trial designed demonstrate whether treatment saves lives meantime strategies enhance scs regenerative potential applied suggested position papers recommendations published learned far properly use knowledge gained review analytically discuss topics summarizing current state knowledge field
background study aimed determine frequency entamoeba histolytica entamoeba dispar infection school children community tlaltizapan order understand dynamics infection within school family spheres population amoebiasis unsolved public health problem endemic disease mexico incidence rate varies depending state affected states show highest numbers new cases amoebiasis per year previously reported molecular frequency infection histolytica dispar rural communities state morelos methods children schools studied estimate frequency intestinal parasites microscopic examination fresh stool samples number studied individuals school children molecular characterization histolytica dispar carried polymerase chain reaction pcr using species specific primers amplify short tandem repeats str non coding sequences associated trna gene amplified fragments sequenced analyzed results eight different genotypes obtained dispar isolates molecular marker nkd none cases species histolytica detected developed symptoms attributable invasive process disease moreover parasitized condition appeared significant impact development nutritional status affected children genotype corresponds reference strain dispar saw considered non pathogenic amoeba prevalent conclusions comparison genotypes entamoeba species show correlation children relatives community species entamoeba dispar genotype widespread based indicators growth development nutrition status studied community seems reasonably adapted constant exposure intestinal parasites since evidences serious impact parasitized condition children health
nowadays production enterprises faced array challenges including increasing pressure regarding costs demands individualized products well growing significance logistic performance costs name turn give rise special requirements production planning control monitoring among others need meet suitable methods techniques within context developments industry cyber physical production systems technology side approaches innovative learning factories training employees hold great potential paper clarifies advantages cyber physical systems view production planning controlling monitoring based using concept ifa learning factory describes specifically utilized applying logistic models improve order processing authors published elsevier
common approach model memristive systems include empirical window functions describe edge effects nonlinearities change memristance demonstrate quite general conditions window function associated sigmoidal curve relating normalised time dependent memristance time integral input conversely explicit relation allows derive window functions suitable mesoscopic modelling memristive systems variety well known sigmoidals sigmoidal curves defined terms measured variables thus extracted input output signals device transformed corresponding window also introduce new generalised window function allows flexible modelling asymmetric edge effects simple manner copyright john wiley sons ltd
purpose reviewmultiple disease processes including neoplasia trauma medication side effects necessitate segmental resection subsequent reconstruction mandible surgical techniques advanced several technologies developed potential significantly transform surgeon approach restoration mandibular continuity purpose review highlight many relatively newer tools discuss evolving role mandibular reconstruction recent findingsseveral contemporary studies documented application different approaches modifications mandibular reconstruction including computer aided design computer aided modeling contemporary plating systems osseointegrated implants various modifications existing osseocutaneous free tissue transfer options reported relatively high success rates summaryin discussing reports present survey current developing technologies field mandibular reconstruction aim provide sufficient context gradual integration techniques practice
study investigates signal difference based deadband control approach solution reduce data transmission networked control systems ncss new modelling method ncss time varying delays time varying sampling intervals signal transmission deadbands presented lyapunov functional discontinuity exploited takes full advantages ncss characteristic information including bounds network delay bnd bounds sampling interval bsi bounds transmission deadband btd addition shown lyapunov functional decreases jump instants furthermore new stability analysis stabilisation conditions ncss proposed describes relationship bnd bsi btd system stability three examples used demonstrate effectiveness proposed methods simulation results shown proposed approach could guarantee system asymptotically stable effectively reduce data transmission network channel
analog filters key blocks analog signal processing widely employed many systems like wireless transceivers detectors read sensors interfaces etc technology choice systems mainly dictated requirements high speed low power consumption digital circuits pushed impressive movement towards scaled technology important consequences analog circuits design impact technology scaling nanometre scale analog filters design investigated instance supply voltage reduction analog filters limits circuits design solutions could result higher power consumption moreover time innovative systems push analog filters get higher higher operation frequencies due increasing bandwidth speed requirements recent solutions efficient low voltage high frequency analog filters nanometre technology described
main purpose study evaluate psychological skills training intervention group level aiming prevent injuries separated traumatic overuse male female elite floorball players twenty three teams premiere leagues males females volunteered teams allocated intervention group males females control group males females teams intervention group participated psychological skills training programme consisting six meetings team control group received substitute injuries registered documented according time loss definition classified either traumatic overuse total players players sustained injuries injury player intervention group injury player control group injury player analyses revealed significant differences injuries intervention groups control groups effect size influence psychological skills training overuse injuries considered small cohen study comprised whole team group intervention screen risk athletes scoring high anxiety low coping skills might influenced result psychological injury prevention intervention forward whole team might influence injury occurrence significantly thus psychological intervention decreased injury incidence clinical interest level
explosive growth mobile terminal access network shortage ipv network address translation nat technology become widely used technology provides users convenient access internet also brings trouble network operators regulatory authorities system nat detection using netflow data often used monitoring forensics analysis large networks paper order detect nat devices activity degree method based network behavior proposed approach works completely passively based netflow data approach gets accuracy real large scale network long time
smart camera vision system capable extracting application specific information captured images paper proposes decentralized efficient solution visual parking lot occupancy detection based deep convolutional neural network cnn specifically designed smart cameras solution compared state art approaches using two visual datasets pklot already existing literature cnrparlc ext former existing dataset allowed exhaustively compare previous works latter dataset created context research accumulating data across various seasons year test approach particularly challenging situations exhibiting occlusions diverse difficult viewpoints dataset public available scientific community another contribution research experiments show solution outperforms generalizes best performing approaches datasets performance proposed cnn architecture parking lot occupancy detection task comparable well known alexnet three orders magnitude larger elsevier ltd rights reserved
background study aim high physical fitness requirements towards judokas well combat specificity may foster bodily injuries research objective identify spinal joints hip joints shoulder joints mobility relation bodily injuries sustained men practising judo professional amateur sportsmen material methods forty one men practising judo divided two groups according level sport advancement considered participation study group study group professional sportsmen group control group recreational amateur sportsmen research tool consisted series functional tests dega wall test thomas test thomayer test zipper back scratch test well custom survey training methods number type circumstances contracted injuries well treatment methods results iliopsoas contracture observed judokas judokas thirteen practitioners scored negative dega test compared judokas judokas scored negative back scratch test significant asymmetry also observed groups discrepancy left right side amounted notably higher number bodily injuries noted among professional judo athletes conclusions degree functional limitations may effect yet also cause bodily injuries majority professional practitioners limited joint flexibility may increase risk injury body part demonstrates insufficient amount stretching exercises training
objective successful psychoeducation program serious mental illness psychoeducation responsive families perf modified hepatitis virus hcv effectiveness study carried comparing hcv perf didactic education patients methods sample adult hcv patients recruited three outpatient settings randomized hcv perf didactic control groups met min bimonthly months following separate structured protocols hcv perf sessions included didactic curriculum developed uniquely groups member choice group problem solving support interactions patients assessed baseline intervention year later demographic hcv related variables structured diagnostic interview data obtained results groups improved significantly major depression alcohol drug use quality life risk behaviors treatment satisfaction worsened disability perceived hcv related problems intervention groups differ outcomes conclusion even though active intervention achieve significant improvement relative control condition observable improvements conditions warrant exploration contributions education support potentially important elements hcv behavioral intervention study needed identify elements common education interventions may contributory improved outcomes time copyright wolters kluwer health inc rights reserved
two classes rational solutions shallow water wave like non linear differential equation constructed basic object generalized bilinear differential equation based prime number new transformation help symbolic computation maple new equation rational solutions obtained
paper presents comparison two inlet permanent magnet synchronous machines concentrated windings novel teeth poles machine design flux barriers stator teeth compared common teeth poles design widely used hybrid electric vehicle hev applications detailed comparison important machine characteristics torque ripple iron losses eddy current losses magnets axial length machine weight presented according study novel teeth poles machine design offers high saving potential concerning space requirement production costs time machine topology generates smoother torque compared teeth poles topology
background genetic susceptibility asthma currently linked handful genes limited ability predict overall disease risk suggesting existence many genes involved disease development accumulated evidence association studies genes related biological pathways could reveal novel asthma genes objective reveal novel asthma susceptibility genes means pathway based association study methods based summary data previous genomewide association study gwas asthma first identified significant biological pathways using gene set enrichment analysis mapped tested single nucleotide polymorphisms snps genes contributing significant pathways prioritized disproportionate number nominal significant associations studies prioritized genes association studies performed selected snps independent case control samples using logistic regression models results meta analysed gwas results two biological processes significantly enriched cytokine cytokine receptor interaction wnt signalling genes interacting two pathways showed excess nominal associations including known asthma susceptibility locus encoding smad family member novel candidate genes latter association studies selected snps evidenced replication locus near frizzled class receptor fzd gene consistent direction effects gwas findings meta analysed odds ratio high linkage disequilibrium expression quantitative trait loci lung tissues conclusions clinical relevance study revealed importance two biological pathways asthma pathogenesis identified novel susceptibility locus near wnt signalling genes
chronic lymphocytic inflammation pontine perivascular enhancement responsive steroid clippers first described characteristic clinical picture radiological distribution steroid response well described previous reports however underlying pathogenesis nosological position clippers cns require investigation primary cns lymphoma identified autopsy subsequently report year old woman diagnosed clippers progressed primary cns lymphomatoid granulomatosis supports clippers inflammatory cns disorder elsevier rights reserved
paper presents systematic approach develop resilient software system developed emerging services analytics resiliency using resiliency good example enterprise cloud security resilient characteristics blended together produce greater impacts framework cloud computing adoption framework ccaf presented details ccaf four major types emerging services one explained details regard individual function one integrated ccaf architectural framework blends software resilience service components guidelines together provides real case studies produce greater impacts organizations adopting cloud computing security ccaf provides business alignments provides agility efficiency integration business competitive edge order validate user requirements system designs large scale survey conducted detailed analysis provided major question present discussion conclude use ccaf framework illustrate software resilience security improvement enterprise security ccaf framework validated emerging service enterprise cloud computing analytics showing survey analysis elsevier ltd rights reserved
present study examined whether grade point averages gpas university students could predicted appearance based ratings conscientiousness undergraduate participants provided self reports big five personality traits copies student transcripts gpas obtained photographs undergraduates taken personality traits judged unacquainted perceivers aggregated single perceiver ratings conscientiousness predicted gpa aggregated perceiver ratings predicted gpa incrementally self ratings suggesting appearance based judgements conscientiousness may contain trait relevant information beyond scope self reports results contribute growing literature documenting validity appearance based judgements personality traits
paper explores engagement physical activity potential coping strategy asylum seekers living australian community without right work prolonged uncertainty benefits barriers undertaking activity semi structured depth interviews held asylum seekers arrived australia boat living community cities perth sydney melbourne july october release immigration detention ratio numbers men women interviewed men women comparable ratio men women came boat australia seeking asylum nine participants reported participated physical activity coping strategy seven participants worried future families mental physical energy engage physical activity six wanted participate physical activity faced number barriers seven remaining participants either asked physical activity engagement focused discussion challenges elaborate engaging physical activity findings suggest physical activity coupled coping strategies important asylum seekers trying manage distress denied right work living prolonged uncertainty addition findings highlight critical barrier government policy plays disabling engagement physical activity compounds social exclusion includes lack welfare support provided hinders people financial ability access activities support community
social pain often associated social rejection shares neural correlates bothersome aspect physical pain may also indicate overlap function pain described motivational signal respond source pain adaptive way altering behavior tested whether social pain causes similarly adaptive alterations behavior participants played computerized ball tossing tasks putative players one passed one excluded participant play social nonsocial version assessed behavioral consequences social pain comparing number throws stimulus social rejector nonsocial rejector course task posttask questionnaires assessed subjective feelings social pain decrease throws rejecting stimulus observed social version indicating rejection social nature leads change behavior moreover participants reported negative feelings toward rejecting stimulus social nonsocial version subjective feelings social pain mediated effect version game social nonsocial changes behavior indicating social pain social rejection causes changes behavior
background fibronectin type iii domain containing fndc protein product irisin therapeutic targets obesity associated disorders irisin plays important role energy regulation inducing browning white adipocytes improving obesity aimed investigate association muscle irisin expression dietary quality methods twenty eight female mice divided four groups fed following experimental diets days standard diet high carbohydrate diet hcd high fat diet hfd high protein diet hpd evaluated body weight food intake serum total cholesterol triacylglycerol glucose also performed glucose tolerance insulin sensitivity tests expression fndc evaluated quantitative real time reverse transcriptase polymerase chain reaction qrt pcr soleus muscle western blot used assess irisin protein expression results major finding present study hfd hcd associated downregulation fndc addition results noted significant reduction skeletal muscle irisin level hpd prevented reductions fndc irisin levels well increased brown adipose tissue compared control group conclusions conclusion observed hpd type diet change fndc expression irisin levels thus hpd might appropriate diet achieve high amounts irisin target molecule treatment obesity morbidities
swainsonine found several plant species worldwide causes severe toxicosis livestock grazing plants leading chronic condition characterized weight loss altered behavior depression decreased libido infertility death swainsonine detected north american astragalus species eight belong taxa four taxonomic sections densifolii diphysi inflati trichopodi sections belong two larger groups representing several morphologically related species pacific piptolobi small flowered piptolobi objective study screen species swainsonine sections densifolii diphysi inflati trichopodi previously known contain swainsonine furthermore broaden scope species within sections pacific piptolobi small flowered piptolobi screened swainsonine swainsonine detected first time astragalus taxa representing species using liquid gas chromatography coupled mass spectrometry several taxonomic sections highly enriched species contain swainsonine others systematic examination swainsonine species provide important information toxic risk species may valuable reference diagnosticians land managers
personality profiles describe individual persons locations multiple trait dimensions enable calculation profile similarity indices individual persons dyads easily misinterpreted however unless two components distinguished normative component comprising sample means variables distinctive component reflecting given individual deviations means two profile components provide different kinds information focusing person perception research review predictors similarity individual profiles normative profile profile normativeness agreement distinctive profiles also provide suggestions future research
background opioid dependence growing alarming rate united states opioid dependent patients substantial medical well psychiatric conditions impact ability work study evaluated association antisocial personality disorder aspd receipt physical disability payments methadone maintenance patients methods using data drug alcohol abusing methadone maintained patients participating two clinical trials baseline characteristics individuals receiving receiving physical disability benefits compared logistic regression evaluated unique predictors disability status results aspd diagnosis severity medical problems significant predictors disability receipt controlling variables differed groups patients aspd five times likelier receive physical disability benefits patients without aspd odds ratio confidence interval conclusions results demonstrate role aspd receipt disability benefits substance abusers suggest need greater understanding reasons high rates physical disability benefits population elsevier ireland ltd rights reserved
high online engagement common among adolescents besides concerns highly involved adolescents online develop maladaptive patterns use focus present qualitative study explore experiences highly engaged adolescents signs internet addictive behaviors aimed uncover processes differentiating high online engagement formulate typology users semi structured individual interviews conducted adolescents age years living greece spain iceland poland interviews analyzed using grounded theory typology highly engaged adolescents emerged based three processes satisfying needs across contexts online offline experiencing personal gains losses self regulating use four distinct user profiles emerged ranging adaptive juggling coming full cycle maladaptive stuck online killing boredom developed typology help parents teachers professionals better understand ways high engagement experienced within developmental context knowledge inform development prevention supportive services implications assessment intervention discussed profile elsevier ltd rights reserved
based complex grid infrastructure ilmenau interactive hybrid online lab various possibilities occurrence malfunctions well mechanisms avoid discussed demonstrated different examples one implementation challenge protect physical systems lab wrong control algorithms malicious trying sabotage destroy system without defining many design constraints therefore high level safety must guaranteed autonomous working system therefore first step verification sensor actuator constellations guarantee safety online labs based upon efficient possibility validation student design shown subsequent step
objective adolescents puerto rican backgrounds found higher rates obesity adolescents ethnic groups objective study examine whether sleeping recommended number hours depression anxiety disorder independently related risk obesity sample island puerto rican adolescents whether association sleep obesity moderated depression anxiety disorder methods data study derived third wave island wide probability sample puerto rican youth residing island years age response rate current study focuses youth years age results sample youth slept less recommended number hours defined per night significantly increased risk obesity three times likely obese youth met criteria depressive anxiety disorder almost times likely obese however presence anxiety depressive disorders moderate association sleeping recommended number hours risk obesity conclusion sleeping less recommended number hours may important risk factor obesity status island puerto rican youth findings suggest attention healthy sleep behaviors sleep environment promotes high quality sleep may important puerto rican adolescents risk obesity
type diabetes mellitus tdm may associated altered urinary microbiota female patients investigated alterations urinary microbiota chinese female tdm patients explored associations urinary microbiota patient fasting blood glucose fbg urine glucose uglu age menstrual status body mass index bmi midstream urine collected female tdm patients healthy females microbial diversity composition analyzed using illumina miseq sequencing platform targeting hypervariable regions rrna gene found bacterial diversity decreased tdm patients increased actinobacteria phylum positively correlated fbg uglu bmi lactobacillus abundance decreased age menopause increased lactobacillus correlated positively fbg uglu decreased akkermansia muciniphila associated fbg uglu escherichia coli abundance differ two cohorts carbohydrate amino acid metabolism reduced tdm patients associated bacterial richness indices chao ace detailed microbiota analysis well characterized tdm patients healthy controls indicate chinese tdm female patients exhibit dysbiosis urinary microbiota
study objective validate non invasive cardiac output monitor pediatric cardiac surgery patients design prospective trial setting operating room patients pediatric cardiac surgery patients asa physical status interventions aesculon noninvasive cardiac output monitor used compared cardiac output derived fick equation oxygen consumption measured blood samples taken arterial line superior inferior vena cava measurements noninvasive cardiac output cardiac index fick cardiac output cardiac index oxygen consumption measured treymed metabolic monitor blood samples simultaneously drawn arterial line superior inferior vena cava purse string sites surgeon prior commencing cardiopulmonary bypass another data set obtained right termination cardiopulmonary bypass results direct significant relationship fick nicom measurements dispersion detected magnitude measure increases older larger patients conclusions strong correlation cardiac output values derived fick equation aesculon non invasive cardiac output monitor elsevier inc rights reserved
introduction rectovaginal fistulas relatively rare debilitating condition pose significant treatment challenge areas covered manuscript discuss etiology classification well manifestations evaluation rectovaginal fistulas summarize different surgical techniques evaluate success rates perioperative considerations according cited sources expert commentary deep understanding disease treatment options familiarity different surgical treatment options available mandatory choosing correct treatment surgical treatment tailored specific fistula patient many patients eventually successful resolution review address management patient outcomes treatment rectovaginal fistulas
obesity thyroid function closely related thyroid hormones involved regulation metabolism thermogenesis food intake fat oxidation obese children frequent hormonal abnormalities slight hyperthyrotropinaemia moderate increases total concentrations abnormalities usually considered cause obesity according recent studies actually considered adaptation process aimed increasing resting energy expenditure total energy expenditure abnormalities require treatment normalise substantial weight loss mechanisms changes dependent leptin thyroid hormone resistance mitochondrial dysfunction present paper describes mentioned mechanisms based latest research also present review recent original studies evaluating thyroid function overweight obese children including thyroid ultrasound thyroid ultrasound scan obese children frequently shows increased thyroid volume correlates moderately increased tsh levels hypoechoic pattern typical autoimmune thyroiditis without antithyroid autoantibodies alterations thyroid function overweight obese patients cause increase energy expenditure facilitates weight loss prevents weight gain therefore normalisation tsh weight loss could explain difficulties maintaining reduced weight
research deals novel approach classification new classifiers synthesized complex structure via evolutionary symbolic computation techniques compared previous research paper synthesizes multi input multi output mimo classifiers different cost function based distance measurements inspiration work came field artificial neural networks ann proposed technique creates relation inputs outputs whole structure together numerical values could observed weights ann distances used cost functions manhattan absolute distances output vectors euclidean chebyshev maximum distance value canberra distance bray curtis analytic programming utilized tool synthesis means evolutionary symbolic regression experimentation differential evolution main procedure also meta evolution version analytic programming used iris data known benchmark classifiers used testing proposed method
analytical calculation magnetic forces currently interesting alternative time consuming finite element method due high accuracy low computational cost paper new semi analytical solution determining levitation force repulsive magnetic guidance significant role controlling developing high precision magnetic levitation positioning system presented important result new expression compared known equations literature considers position dependence magnetic levitation force whole travel range order derive force magnetic field permanent magnet first calculated introducing solving magnetic scalar potential taking lorentz force law consideration proposed equation finally derived semi analytical equation suitable designing optimizing magnetic guidance furthermore also used developing ironless actuators calculated levitation force derived equation verification measurements likewise presented paper
background employers purchase high quality depression products provide type intensity duration depression care management shown improve work outcomes sufficiently many employers achieve return investment purpose randomized controlled trial test intervention encourage employers purchase high quality depression product workforce methods twenty nine organizations recruited senior health benefit professional members representing public private employers yet purchased depression product workers company research team used randomization blocked company size assign eligible employers presentation encouraging employers purchase high quality depression product accompanied scientifically derived return investment estimate presentation encouraging employers work subscribed health plan improve depression treatment quality indicators two hundred ninety three employers completed baseline data immediately learning employers randomized evidence based depression product presentation randomized usual care depression treatment quality indicator presentation analysis employers completed web based interviews months conducted determine presentation impact depression product appraisal purchasing behavior results intervention impact depression product appraisal subjects depression product purchasing chisquare subjects depression product appraisal increased companies greater health benefit generosity whose benefit professionals male depression product purchasing behavior increased small companies compared large companies companies knew vendor sold depression products baseline companies greater health benefit risk taking companies less politicalization health care benefit decision making conclusions policy makers need build innovative bridges employer community convince purchase evidence based benefits even benefits offer potential financial savings
study reports parallel expander organic rankine cycle orc using dual expanders different capacities system applicable waste heat sources large variation distributed power plants varying electricity demand test bench experimental investigation consists orc loop two different scroll expanders electrical water heating system air cooled chiller tested performance characteristics operating mode presented experimental results show three clearly separated operation regions high efficiency two possible switching points operating mode good heat recovery capability wider range heat input compared orc system two identical expanders control strategy system proposed maintain superheated state inlet expander obtain high performance changing operating mode elsevier ltd rights reserved
effect health education course guided peers aged evaluated aim course empower older adults participate society promote wellbeing evaluation included determining effect attitude toward aging self efficacy perception societal opinion regarding place elderly society social influence social participation perceived social support wellbeing participants aged years quasi experimental approach used effect experimental group course participants studied compared control group older adults waiting list respondents filled postal questionnaires three time points starting course immediately termination three months later using multivariate analysis procedure significant interaction effect time measurement group membership found respect outcome social influence effect absent current idea elderly occupy marginal position society found less favour experimental group control group moreover perceived social support subjective health improved significantly among course members compared control group effect found attitude self efficacy social participation wellbeing short time span three months follow elsevier science ireland ltd
connecticut nutmeg state games sport athletic event takes place days july august new middlesex hartford counties course years average athletes competed year year sports medical coverage nutmeg state games coordinated chiropractors article reviews medical contacts involved four games art average total medical contacts produced injury incidence rate injuries minor sprains strains contusions abrasions injuries occurred lower extremities iri juries treated adequately ice compression bandages adhesive bandages basic first aid supplies incidence injury higher contact sports soccer basketball lacrosse reported injuries per participant coverage events requires proficiency basic first aid cardiopulmonary resuscitation treatment soft tissue injuries emphasis lower extremity injuries
handover authentication protocol ensures secure seamless roaming multiple access points number protocols proposed protocols inefficient insecure recently wireless pers commun proposed privacy aware handover authentication protocol claimed protocol lightweight secure existing protocols however analysis identifies protocol insecure access point impersonation attack remedy proposed improved protocol fix security weakness protocol improved protocol achieves provable security random oracle model hardness assumptions elliptic curve discrete logarithm problem elliptic curve computational diffie hellman problem proposed handover authentication protocol also formally analyzed automated tool proverif improved protocol enhances security lightweight related protocols
psychiatrists mandated report suspicions child abuse america potential harm children considered one treating parents risk although commonly held wisdom mental illness major risk factor child abuse methodologic issues studies purporting demonstrate rather risk individual parent must considered substance abuse personality disorder pose separate risk serious mental illness violence risk mental illness dynamic rather static severe mental illness well treated risk decreased however families need social support
nowadays even though cognitive control architectures form important area research many constraints broad application cognitive control industrial level systematic approaches truly inspired biological processes perspective control engineering thus main purpose emulation human socio cognitive skills approach control engineering problems effective way industrial level artificial cognitive control architecture propose based shared circuits model socio cognitive skills seeks overcome limitations perspectives computer science neuroscience systems engineering design implementation artificial cognitive control architecture focused four key areas self optimization self leaning capabilities estimation distribution reinforcement learning mechanisms portability scalability based low cost computing platforms iii connectivity based middleware model driven approaches results simulation real time application force control micro manufacturing processes presented proof concept proof concept force control yields good transient responses short settling times acceptable steady state error artificial cognitive control architecture built low cost computing platform demonstrates suitability implementation industrial setup elsevier rights reserved
paper reliable symbolic computational algorithm presented inverting general comrade matrix using parallel computing along recursion computational cost algorithm algorithm implementable computer algebra system cas maple matlab mathematica three examples presented sake illustration
pneumothorax possible complication tracheostomy report rare case bilateral pneumothoraces resulting tracheostomy advanced laryngeal cancer patient year old man referred clinic evaluation treatment laryngeal tumor laryngeal endoscopy showed limited movement bilateral vocal cords computed tomography revealed tumor lesion extending vocal cords subglottic area three days first visit patient developed respiratory difficulty elected perform emergency tracheostomy airway management immediately start procedure began hyperventilating complained respiratory discomfort chest pain recognized mediastinal air leak suspected pneumothorax resulting tracheostomy chest ray showed bilateral pneumothoraces therefore inserted bilateral chest drainage tubes stabilized respiratory condition speculated pathogenesis bilateral pneumothoraces weakened alveolar walls secondary long term smoking significant rise airway pressure airway constriction neck extended position hyperventilation tracheostomy elsevier ireland ltd rights reserved
objectives women risk developing somatic psychiatric symptoms menopausal transitions occurrence major depressive disorder study aimed evaluate characterize presence depressive status sample perimenopausal menopausal postmenopausal women materials methods women diagnosis depressive disorder dsm criteria spontaneously referred psychiatric evaluation perimenopausal menopausal postmenopausal stages enrolled study results patients years diagnosed unipolar disorder dysthymia bipolar disorder cyclothymia cases respectively axis morbidities present patients respectively significant differences prevalence disorders morbidities different climacteric stages observed ham ham bdi rating scale scores respectively severe severe symptoms patients respectively gcs scale showed depression anxiety patients general somatic vasomotor scores respectively conclusions results describe psychopathological scenario women underwent psychiatric evaluation different menopausal transitions although results show significant differences among stages suggest major psychiatric impairment several patients affected severe disorders
metabotropic glutamate receptor mglur expressed neurons zones active neurogenesis involved development neural stem cells vivo vitro examined expression mglur cortex hippocampus rats various prenatal postnatal periods using immunohistochemistry prenatal development mglur primarily localized neuronal somas forebrain early postnatal periods receptor mainly present somas cortex mglur immunostaining visible apical dendrites neuropil neurons persisted throughout postnatal development period pyramidal neurons strongly labeled receptor hippocampal region mglur immunoreactivity intense stratum oriens stratum radiatum lacunosum moleculare relative mglur expression increased significantly molecular layer decreased significantly granule cell layer dentate gyrus comparison furthermore mglur positive cells also bromodeoxyuridine neurod positive dentate gyrus results demonstrate mglur differential expression pattern cortex hippocampus early growth suggesting role receptor control domain specific brain developmental events
construct differential invariants lie symmetry pseudogroups dimensional breaking soliton equation analyze structure induced differential invariant algebra syzygies recurrence relations classified addition moving frame invariantization breaking soliton equation also presented algorithms based method equivariant moving frames
network security technologies different issues important next generation networks real time nature applications voip iptv main requirements types applications handle attack situations without quality degradation many references implementation intrusion detection systems voip infrastructures little effort intrusion response systems concentrate response systems sip based entities present cost sensitive response system considers environmental dynamic conditions categorize deployable responses different groups based severity level considering side effects also propose new quantitative metric damage cost compare response cost proposed decision making process done based comparison costs response damage costs environmental conditions cpu network memory usages also time detected attack verify proposed framework real test bed implemented open source tools opensips sipp implementation results show effectiveness proposed sip intrusion response system
paper discusses importance three features psychometric tests cognition research construct definition problem space knowledge domain definition constructs intelligence creativity forms theoretical basis test construction problem space well ill defined determined cognitive abilities considered belong constructs convergent thinking intelligence divergent thinking creativity knowledge domain possibilities offers cognition reflected test results argue comparing results tests different problem spaces informative cognition operates tests identical knowledge domain intertwining abilities related constructs expected tests developed instigate process test features guarantee abilities contribute self generated goal directed processes bringing forth solutions new applicable propose discuss test example developed address issues
session initiation protocol sip signaling communications protocol widely used controlling multimedia communication sessions recently yeh presented ecc based authenticated protocol sip conquer various attacks found earlier schemes paper analyze security yeh scheme identify yeh scheme insecure demonstrate vulnerability yeh scheme resist line password guessing attack scheme also lacks forward secrecy aim propose efficient improvement yeh scheme overcome security weaknesses found yeh scheme retaining original merits rigorous informal security analysis formal security analysis using widely accepted burrows abadi needham logic ban logic show scheme secure various known attacks including attacks found yeh scheme furthermore simulate scheme formal security analysis using widely accepted avispa automated validation internet security protocols applications tool show scheme secure passive active attacks including replay man middle attacks additionally proposed scheme efficient terms communication computational overheads compared yeh scheme related existing schemes demonstrate practicality scheme evaluate proposed scheme using broadly accepted network simulator
paper presents investigation high energy rate micro forming hermf thin aluminum foil using high velocity forming hvf technique model proposed work deformation efficiencies involved every stage energy transfer forming action achieved incident shockwaves cause plastic deformation blank take shape die cavity shockwaves generated rapid capacitive discharge energy across fuse wire inside water paper presents analysis predict amount energy required desired depth hemispherical deformation based principles plastic deformation volume constancy energy transferred capacitor bank fuse wire modeled using kirchhoff voltage law joule heating principle indigenous micro electro hydro forming ehf setup developed house used validate analytical model developed set experiments readings optimized number parameters present entire process validation suggested analytical model carried comparing theoretical experimentally measured values depth deformation thick aluminum foil results obtained encouraging highest error predictive ability model found best knowledge first attempt analytically modeling depth deformation given value supplied electrical energy micro domain
structure damage identification alarming long span bridge conducted three dimensional dynamic displacement data collected gps subsystem health monitoring system runyang suspension bridge first effects temperature main girder spatial position coordinates analyzed transverse longitudinal vertical directions bridge correlation regression models built temperature position coordinates main girder longitudinal vertical directions alarming indices coordinate residuals conducted mean value control chart applied making statistical pattern identification abnormal changes girder dynamic coordinates finally structural damage alarming method main girder established analysis results show temperature remarkable correlation position coordinates longitudinal vertical directions bridge weak correlation transverse coordinates abnormal change longitudinal coordinates abnormal change vertical ones caused structural damage respectively identified mean value control chart method based gps dynamic monitoring data hence structural abnormalities state identification damage alarming main girder long span suspension bridge realized multiple directions
catheter ablation provides effective treatment option patients suffering symptomatic atrial fibrillation procedural cornerstone ablation strategies entities electrical isolation pulmonary veins use radiofrequency conjunction dimensional electroanatomical mapping system established ablation approach demands long learning curve recurrences commonly result recovered conduction consequence novel ablation systems cryoballoon evolved aiming facilitation increased efficacy pulmonary vein isolation pvi ablation characterized short learning curve well short procedure times demonstrated non inferiority regard safety efficacy directly compared ablation treatment paroxysmal however ablation first choice treatment persistent particular expanded ablation strategies beyond pvi intended order improve clinical outcomes
aimed investigate effects aerobic exercise pain perception sensitivity health related quality life assess effect parasympathetic tonus analysis heart rate recovery examine effects parasympathetic tone pain sensitivity patients chronic musculoskeletal pain fifty patients chronic musculoskeletal pain randomized two groups control group group aerobic exercise group group groups received conventional physical therapy weeks group performed submaximal aerobic exercise treadmill min additionally exercise test pressure pain threshold measurement short form visual analog scale administered initially finally evaluation visual analog scale scores groups decreased significantly treatment pressure pain threshold sum increased significantly group remaining unchanged group increase exercise test duration significant group compared group heart rate recovery change therapy groups short form group showed alterations role limitations physical problems general health perceptions groups showed significant improvement physical function bodily pain subscales mental health significantly improved group short term aerobic exercise along conventional physical therapy decreased pain sensitivity increased aerobic capacity significant improvements health related quality life copyright wolters kluwer health inc rights reserved
data communication network changed way business daily affair works rely computer network internetwork computer network telecommunication channel share data also called data network security data transmission one important aspects considered modern communication system paper data transferred sent certain pattern embedded huge amount data seen everyone effectiveness proposed method described way increase security data hide data binary image key needed rather algorithm based binary tree traversal bits plotted msb significant bit lsb least significant bit middle bit byte proposed algorithm assures data hiding security
purpose purpose study investigate extent ophthalmologists optometrists sweden recommend use nutritional supplements changes diet smoking cessation patients risk signs age related macular degeneration amd addition study also examined practitioners rate strength evidence nutritional supplements amd management sources information consult determine supplement recommendations prevention treatment amd methods study implemented cross sectional design using data questionnaire swedish optometrists ophthalmologists registered membership databases respective professional organizations invited participate questionnaire contained forced choice questions one free text question organized following four sections use nutritional supplements dietary advice smoking eye diseases strength evidence sources information regarding nutritional supplement interventions results response rate optometrists ophthalmologists optometrists likely ophthalmologists recommend nutritional supplements amd provided significantly advice diet ophthalmologists patients risk amd established disease ophthalmologists likely optometrists rely findings age related eye disease studies amd regarding treatment selection supplements recommend smoking cessation conclusion common evidence based strategies amd management among eye care professionals would presumably beneficial amd patients targeted education implementation strategies may needed
objectives objective investigate incidence multiple sclerosis well estimate prevalence january southeastern norwegian county buskerud materials methods patients living buskerud county norway january january identified point prevalence identified january results found prevalence per sex ratio female prevalence per male prevalence per population confirmed relapsing remitting disease onset primary progressive mean annual incidence per conclusion study shows high incidence buskerud county southeastern norway incidence may still rise found relatively high prevalence population although correspond recently published national data studies investigating changes incidence possible factors causing increasing incidence warranted
like natural climate change planet earth climate software development environments also changing fast like natural weather software environment also disruptive climate experts alert suggest taking necessary measures overcome certain challenges make earth safer comfortable living place likewise article also alerts relevant stakeholders software craftsmanship dynamic challenges traditional software engineering purely engineering mind set capable respond hence new thoughts overcome challenges shared fundamentally based historical evidences article presents authors observation continuous shift traditional engineering based software development approaches disruptive approaches vibrant softology authors see cause shift disruptive transformational force powerful uncontrollably diminishing engineering based approach software development environments authors align climate change analogy based analogy authors feel need theoretically coin notion new term perhaps vibrant dynamic softology hence authors suggest new disruptive dynamic way thinking required develop software worth mentioning purpose article new theory disparage notion software engineering altogether rather aim highlight importance transformation next level perhaps due emerging needs software craftsmanship environment
recent forecasts suggest african countries must triple current electricity generation multicriteria assessment wind solar potential large regions africa shows economically competitive low environmental impact renewable resources significantly contribute meeting demand created multicriteria analysis planning renewable energy mapre framework map characterize solar wind energy zones countries southern african power pool sapp eastern africa power pool eapp find potential several times greater demand many countries significant fractions demand quickly served regrets options zones low cost low environmental impact highly accessible regrets options spatially heterogeneous international interconnections necessary help achieve low carbon development region whole interconnections support best renewable options may differ planned hydropower expansion additionally interconnections selecting wind sites match demand reduce need sapp wide conventional generation capacity high wind scenario resulting cost savings depending avoided conventional technology strategic selection low impact accessible zones cost effective interconnections compared solutions without interconnections overall results robust multiple load growth scenarios together results show multicriteria site selection deliberate planning interconnections may significantly increase economic environmental competitiveness renewable alternatives relative conventional generation
background resource limited settings high prevalence human immunodeficiency virus hiv infection zambia decentralization hiv acquired immunodeficiency syndrome hiv aids treatment care effective use resources cornerstone universal treatment care objectives research aims analyse cost effectiveness national mobile antiretroviral therapy art services programme zambia means decentralizing art services methods cost effectiveness analyses performed using decision analytic model markov model compare original art programme hospital based art intervention programme hospital based plus mobile art perspective district government health office zambia total cost art services quality adjusted life years qalys incremental cost effectiveness ratios icers examined results mean annual per patient costs usd original programme usd intervention programme mean number qalys original intervention programme icer intervention programme relative original programme usd qaly much willingness pay wtp three times gdp per capita usd still gdp per capita usd sensitivity analysis icer intervention programme substantially change conclusion national mobile art services programme zambia could cost effective approach decentralizing art services rural areas zambia programme could expanded districts yet introduced improve access art services health people living hiv plhiv rural areas
within framework spanish universities involved ects credit must considered working hours needed students acquire subject related knowledge capabilities skills work presented paper consists analyzing data obtained surveys made students registered manufacturing engineering subjects technical university cartagena information lets estimate workload needed subject adaptation process within european higher education area framework
traditional active contour models segment remote sensing river images accurately solve problem novel active contour model based modified symmetric cross entropy proposed proposed model external energy constraint terms defined symmetric cross entropy region fitting centers represented medians pixel grayscale values inside object background regions moreover penalty energy term incorporated energy functional avoid initialization order improve segmentation efficiency proposed model chebyshev distance pixel grayscale values inside region region fitting center chosen region energy weight adaptively adjusted instead constant region energy weight extensive experiments performed large number remote sensing river images results demonstrate compared model gac model ceacm model rsf model lif model lgif model proposed model segment images accurately rapidly clear advantages segmentation performance segmentation efficiency elsevier ltd rights reserved
demand clean power source used run various types vehicles road increasing daily basis due fact high emissions released internal combustion engine play significant role air pollution climate change fuel cell devices particularly proton exchange membrane pem type strong candidates replace internal combustion engines transport industry pemfc technology still many challenges including high cost low durability hydrogen storage problems limit wide world commercialization technology paper fuel cell cost durability performances challenges associated using fuel cell technology transport applications detailed reviewed recent developments deal proposed challenges reported furthermore problems hydrogen infrastructure hydrogen storage fuel cell vehicle discussed hydrogen energy publications llc published elsevier ltd rights reserved
background hiv aids major public health problem ethiopia university students often young sexually active group risk acquiring transmitting hiv assessed risky hiv sexual behaviors utilization voluntary counseling testing services among undergraduate students addis ababa science technology university ethiopia methods cross sectional study conducted may june standardized semi structured self administered questionnaire used collect data simple random sampling technique use select departments school students selected departments study participants data entered epi info analyzed using spps statistical packages value considered statistically significant results total students selected overall response rate registered among participants males student ages ranged years mean age around age group years among study participants sexual contact mean age first sexual encounter years students knew condoms prevent sexually transmitted infections stis among sexually active students used condom first time sex among responded heard information vct however ever used vct service overall mean score knowledge attitude students towards risk perception hiv around respectively students enrolled health science departments almost three time knowledge aor two half times favorable aor attitudes towards hiv risk reduction strategies students non health related departments conclusions students engaged risky sexual behaviour even though heard hiv aids perception risk acquisition hiv infection utilization vct low hiv prevention control strategies including education areas hiv aids part university programs curriculum specially non health students strengthening health institutions provide youth friendly vct services hiv know hiv status campaigns strongly recommended
paper describes new calibration system developed inmetro guarantee traceability low frequency alternating current voltage calibrations khz programmable josephson waveform synthesizer automated full synchronous system allows synchronization commercial calibrator signal synthesizer programmable josephson voltage synthesizer system made employing digital sampling signal processing techniques aided adaptive digital control allows accurate determination spectral content signals minimum human intervention system operation measurement techniques data analysis detailed
correcting common misconception seems likely corrective feedback effective needs believed experiments assessed participants belief validity corrective feedback regarding individual misconceptions influenced knowledge revision responding validity set misconceptions participants received either refutation alone feedback correct incorrect refutation accompanied supporting explanation rated belief corrective feedback one week later participants responded validity misconceptions across experiments participants corrected misconceptions often believed corrective feedback addition participants corrected misconceptions often earlier received refutation supporting explanation received refutation benefit supportive explanations knowledge revision mediated belief feedback suggesting explanations enhance effectiveness correction increasing belief feedback findings imply successful correction common misconceptions likely enhanced techniques increase people belief validity corrective feedback
current study addresses gender roles stereotypes produced context cypriot society representations postage stamps produced republic cyprus theoretical framework employed derives relevant theories social roles divisions based gender well way roles stereotypes expressed images corpus analyzed means content analysis semiotic analysis employed order explore theoretical framework complies selected stamps content analysis respect non verbal signs according findings role women stamp representations seems secondary tied emotional qualities men seem hold prominent position society fact reflected quantity stamps representing gender respective thematic categories well selected stamps studied semiotic analysis nonetheless strong indications social roles genders therefore stereotypes started changing society progresses years process however seem apparent imagery used stamps republic cyprus
computing requires distributed computing performed social network platform high scalability security protocol models meeting requirements computing ensure correctness robustness distributed computing also reduce risks introduced involvement nodes low reputation computing models safeguard data collections computations performed platform teacher learning community social researches paper constructs protocol model entitled adapts platform teacher learning community meets requirements computing protocol model key step implementing distributed computations learning community platform
paper based similarity transformation auxiliary equation method construct many exact solutions coupled nonlinear schrodinger equations variable coefficients include soliton solutions combined soliton solutions triangular periodic solutions jacobi elliptic function solutions combined jacobi elliptic function solutions solutions may give insight many considerable physical processes
article addresses problem active structural vibration control means embedded piezoelectric actuators topology optimization method using solid isotropic material penalization simp approach employed work find optimum design actuators taken account control spillover effects coupled finite element model structure derived assuming two phase material structural model written state space representation proposed optimization formulation aims determine distribution piezoelectric material maximizes controllability given vibration mode undesirable effects feedback control residual modes limited including spillover constraint term containing residual controllability gramian eigenvalues optimization shape placement conventionally embedded piezoelectric actuators performed using sequential linear programming slp algorithm numerical examples presented considering control bending vibration modes cantilever fixed beam linear quadratic regulator lqr synthesized case controlled structure order compare influence additional constraint elsevier ltd rights reserved
new concept proposed full wave computer aided design microwave filters method consists two stages operates zeros poles transfer function derivatives quantities evaluated response computed full wave electromagnetic solver two levels accuracy two stages make use different models optimized using low accuracy electromagnetic solver design involves one coarse level optimization first stage iterations second stage requiring single computation high accuracy response effectiveness proposed technique demonstrated two examples design closure achieved three evaluations high accuracy full wave solutions irrespective quality initial design
paper proposes probabilistic optimization method produces optimal bidding curves submitted aggregator day ahead electricity market intraday market considering flexible demand customers based time dependent resources batteries shiftable demand taking account possible imbalance costs well uncertainty forecasts market prices demand renewable energy sources res generation optimization strategy aims minimize total cost traded energy whole day taking account intertemporal constraints proposed formulation leads solution different linear optimization problems following natural temporal sequence electricity spot markets intertemporal constraints regarding time dependent resources fulfilled scheduling process performed day ahead market clearing different problems moderate dimension requires short computation times benefits proposed strategy assessed comparing payments done aggregator sample period one year following different deterministic probabilistic strategies results show probabilistic strategy reports better benefits aggregators participating power markets
oncogenic kaposi sarcoma associated herpesvirus kshv principal causative agent primary effusion lymphoma pel mostly seen immunosuppressed patients pel rapidly progressing malignancy median survival time approximately months even conventional chemotherapy recently report hepatocyte growth factor hgf met pathway highly activated pel cells represents promising therapeutic target blood however underlying mechanisms met activation within pel cells remain largely unknown solve puzzle utilized next generation sequencing ngs based bioinformatics approach investigate genomic landscape met gene found single nucleotide variations snvs occurred met genomic regions cohort pel samples consistently sanger sequencing analysis frequently mutated exons exon shows mutation met exons pel cell lines supports notion mutations major mechanism responsible met activation pel found transmembrane receptor protein plexin expressed pel cell lines required met mediated pel cell survival via direct protein interaction
article argues news coverage plays important role national identity building way evaluates nation better foreign nations group group bias notion transferred media element national cultural identity article identifies analogies national identity building mass media third person perception states people assume others vulnerable negative media influences hypothesized patterns international third person perception occur news coverage news media present media influences country weaker countries first standardized content analysis newspaper coverage germany elections countries supports hypothesis consequences discussed directions future research pointed
modular multilevel converter mmc represents recent development among diverse available topologies vsc allegedly suitable solution converters hvdc transmissions paper presents average value model avm mmc still includes characteristic internal dynamics non existent traditional level vscs avm control described linearized order obtain state space model mmc easily used subsystem multi terminal hvdc mtdc grids case study showing level mmc based hvdc link simulated emtp software validates proposed state space representation mmc
autism spectrum disorder specific knowledge deficits contribute current disparities timing quality autism spectrum disorder services throughout united states globally study conducted systematic review western international literature examine measures used assess autism spectrum disorder knowledge review identified unique autism spectrum disorder knowledge measures across studies conducted countries measures used study evaluated terms psychometric strength studies reviewed rated using measure strong psychometric support compared rated using measure reported psychometric support additionally examined content overlap subdomains autism spectrum disorder knowledge assessed etiology symptoms cross cultural adaptation procedures utilized field based findings need cross culturally valid psychometrically sound measure autism spectrum disorder knowledge discussed recommendations improving current assessment methods presented including suggestions measure subdomains
background lung cancer leading cause cancer related morbidity mortality worldwide patients chronic respiratory diseases chronic obstructive pulmonary disease copd exposed higher risk developing lung cancer chronic inflammation may play important role lung carcinogenesis among patients present study aimed identifying candidate biomarker predicting lung cancer risk among patients chronic respiratory diseases methods applied clinical bioinformatics tools analyze different gene profile datasets special focus screening potential biomarker chronic inflammation lung cancer transition adopted vitro model based lps challenged cells validate biomarker rna sequencing quantitative real time polymerase chain reaction western blot analysis results bioinformatics analyses enrolled gse datasets gene expression omnibus online database showed myocyte enhancer factor mefd level significantly increased copd patients coexisting non small cell lung carcinoma nsclc inflammation challenge increased mefd expression nsclc cell line associated severity inflammation extracellular signal regulated protein kinase inhibition could reverse regulation mefd inflammation activated mefd played critical role nsclc cell bio behaviors including proliferation differentiation movement conclusions inflammatory conditions led increased mefd expression might contribute development lung cancer influencing cancer microenvironment cell bio behaviors mefd might potential biomarker chronic inflammation lung cancer transition predicting risk lung cancer among patients chronic respiratory diseases
network interdependent users expenditure security measures entity affects also users interacting result users efforts toward security viewed public good optimal provision system self interested entities requires design appropriate incentives external mechanism paper propose notion exit equilibrium study users voluntary participation incentive mechanisms show fundamental result due non excludable nature security exists reliable mechanism incentivize socially optimal investments ensuring voluntary participation maintaining weakly balanced budget instances security games illustrate result analyze performance two well known incentive mechanisms namely pivotal vcg externality mechanisms security games illustrate given mechanism stable coalitions participating users may emerge leading improved yet sub optimal security status extend impossibility result risk averse users discuss implications viability using cyber insurance contracts improve state cyber security
background better understanding whether nurses smoking behaviours influence engagement smoking cessation interventions needed aim establish whether smoking status nurses associated professional smoking cessation practices methods twelve electronic databases covering english spanish language publications jan mar systematically searched studies included reported nurses smoking cessation practices relation personal smoking habits proportions nurses smoking status smoking cessation practices pooled across studies using random effects meta analysis results fifteen studies included systematic review levels reportedsmoking cessation interventions generally low across studies meta analyses suggested nurses personal smoking status associated significantly nurses always asking patients smoking nurses smoked less likely advise patients quit less likely arrange smoking cessation follow intense interventions assessing motivation assisting significantly associated smoking status nurse conclusions smoking status nurses appears negative impact delivery smoking cessation practices overall level nurses engagement delivery smoking cessation interventions requires attention nurses effective agents smoking cessation crown copyright published elsevier ltd rights reserved
background response growing demand urgent care services need implement effective strategies primary care support patients complex care needs improving primary care management kidney health implementation sick day rules temporary cessation medicines prevent acute kidney injury aki potential address major patient safety issue reduce unplanned hospital admissions aim study examine processes may enable constrain implementation sick day rules aki prevention routine care delivery primary care methods forty semi structured interviews conducted patients stage chronic kidney disease purposefully sampled general practitioners practice nurses community pharmacists either implemented sick day rule normalisation process theory used framework data collection analysis results participants tended express initial enthusiasm sick day rules prevent aki fitted delivery comprehensive care however interest tended diminish consideration factors influencing implementation included engagement within across services consistency clinical message resources available implementation participants identified supporting patients multiple conditions particularly chronic heart failure made tailoring initiatives complex conclusions implementation aki initiatives routine practice requires appropriate resourcing well training support patients clinicians tailored local level support system redesign
paper propose two new algorithms hardware implementations normal basis multiplication element case proposed multipliers designed using serial digit serial hardware architectures normal basis multipliers based two proposed algorithms compute multiplication matrices order speed execution time reduce area resources seen new hardware architecture multiplier best characteristics area complexity presented reyhani time complexity presented azarderakhsh reyhani proposed hardware architectures normal basis multipliers described vhdl simulated synthesized using modelsim quartus prime respectively
databases imperative research bioinformatics computational biology current challenges database design include data heterogeneity contextdependent interconnections data entities challenges drove development unified data interfaces specialized databases curation specialized databases ever growing challenge due introduction new data sources emergence new relational connections established datasets open source framework curation specialized databases proposed framework supports user designed models data encapsulation objects persistency structured interfaces local external data sources malacards biomodels national centre biotechnology information ncbi databases proposed framework implemented using java development environment eclipselink data persistency agent apache derby database manager syntactic analysis based jsoup apache commons dom open libraries finally construction specialized database aneurysms associated vascular diseases demonstrated database contains dimensional geometries aneurysms patient clinical information articles biological models related diseases recently published model aneurysms risk rapture framework available http nbel lab com
paper addresses treatment patient whose pathology result intergenerational transmission unprocessed traumatic parental issues deeds could mentalind hence unable transformed worked instead evacuated acting unaileviated persecutory guilt following wake patient besieged internal state led development symptoms offered hope freedom terrors however solution could succeed long enmeshment parental history remained unprocessed patient unconscious entanglements fully understood worked significant changes could occur finally freeing patient grip debilitating symptoms
multiple sclerosis chronic disseminated inflammation central nervous system thought driven autoimmune cells genetic association studies multiple sclerosis large number studies animal model disease support role effector memory helper cells however mechanisms underlying relapses remission chronic progression multiple sclerosis animal model experimental autoimmune encephalomyelitis clear particular scarce information role central nervous system invading naive helper cells processes applying two photon laser scanning microscopy could show vivo antigen unexperienced helper cells migrated deep parenchyma inflamed central nervous system experimental autoimmune encephalomyelitis independent antigen specificity using flow cytometric analyses central nervous system derived lymphocytes found antigen specific formerly naive helper cells became activated inflammation central nervous system encountering corresponding antigen
paper genetic algorithm based approach discussed designing heat sinks based total heat generation dissipation pre specified size shape approach combines random iteration processes genetic algorithms finite element analysis fea design optimized heat sink approach prefers survival fittest powerful heat sink designed cool power electronics efficiently resulting designs printed due complexity addition describing methodology paper also includes comparisons different cases evaluate performance newly designed heat sink compared commercially available heat sinks
stealth technology plays major role order make targets unseen enemy radar stealth technology many signatures managed target radar systems use rcs means discrimination targets classification regard stealth paper radar cross section sphere computed respect parameters like size frequency rcs computed using mie scattering series relation given kerr analysis given based spherical polar scattering geometry ans bus defined physical interpretation ans bus coefficients aids visualizing mechanism scattering process paper rcs sphere computed different frequencies particular diameter also rcs computed various diameters different band frequencies rcs treatment paper based radar frequencies ranging ghz ghz
prynne book monogram arguably marks beginning termed late style period avant garde poetic output characterised shift towards monolithic blocks text featuring highly disrupted syntax vocabulary drawn range increasingly technical specialist fields paper considers whether high tech writing requires similarly high tech approach reading describing efforts interpret poem using custom built computer program linked google books database particular examines theoretical implications rudimentary machine reading light existing interpretations poem simon jarvis peter middleton focusing peculiar aesthetic implications exponential technological development arguing monogram text anticipates even acts mechanized dissection complex incorporation sources ranging mother shipton computer programming manuals prynne anticipates disrupts attempt computational processing leaving text paradoxically immune deformed technological progress
paper uses fuzzy neural network modelling identification structural parameters multi storey shear buildings first identification done using response structure subject ambient vibration fuzzy initial condition forced vibration horizontal displacement fuzzified form used investigate identification procedure model developed handle data fuzzified form multi storey shear structure procedure tested identification stiffness parameters simple example problems using prior values design parameters
background despite fact new criteria antisocial personality disorder aspd diagnostic statistical manual mental disorders fifth edition dsm resulted five factor model ffm small amount studies investigate relations proposed personality traits ffm also cross cultural study field continuously would needed aim present study evaluate relation ffm dsm aspd pathological traits materials methods study cross sectional study design participants consisted individuals aspd selected prisoners outpatients inpatients recruited tehran prisoners clinical psychology psychiatry clinics razi taleghani hospitals tehran iran since sample selected based judgmental sampling structured clinical interview dsm axis disorders personality questionnaire neo personality inventory revised dsm personality trait rating form used diagnosis assessment personality disorder pearson correlation used data analysis statistical analyses performed using spss software results results indicate neuroticism positive significant relationship hostility manipulativeness deceitfulness impulsivity negative relation risk taking also significant relationship extraversion manipulativeness deceitfulness agreeableness conscientiousness negative significant relation dsm traits addition results showed positive significant relationship ffm dsm personality traits dsm fourth edition text revision dsm aspd symptoms conclusion except manipulativeness deceitfulness callousness positively significant relationship dsm aspd traits dsm aspd symptoms present study helps understand adequacy dimensional approach evaluation aspd pathology specifically iranian sample
micrornas mirnas small non coding rna molecules function rna silencing post transcriptional regulation gene expression psoriasis inflammatory skin disease characterized dysfunction keratinocytes immune dysregulation reviewed recent studies roles mirnas psoriasis showed mirnas play key roles psoriasis including regulation hyperproliferation cytokine chemokine production keratinocyte well mediating immune dysfunction psoriasis furthermore mirnas particularly circulating mirnas may serve novel biomarkers diagnosis monitoring therapy response reflecting disease severity thus targeting specific mirnas may used develop new therapeutic methods psoriasis
salinity stress one major environmental challenges adversely affects plant growth productivity acquisition salinity stress tolerance interesting area investigation plant abiotic stress management recently investigated interdependency reactive oxygen species ros generating scavenging system offering salt stress adaptation rice continuation earlier findings present study analyzed transcript level expression different respiratory burst oxidase homologs rbohs genes salt sensitive salt tolerant cultivars rice corroborate result activities brassinosteroid known confer abiotic stress tolerance modulating ros machinery hence present study expression key genes associated brassinosteroid biosynthesis signaling salt sensitive tolerant cultivar rice also conducted present investigation stress markers involving proline catabolism anabolism along chlorophyllase analyzed get better insights understanding salt stress adaptation mechanisms rice
study new controllable engine mounting system vibration control passenger vehicles proposed proposed mounting system consists two smart material actuators piezostack actuator magnetorheological fluid actuator first dynamic responses line four cylinder engine supported three rubber mounts mathematically analysed considering six degree freedom motion engine body whose excitation generated inner forces engine combustion process second proper positions two actuators determined two magnetorheological mounts used roll mounts one piezostack mount used right hand mount order reduce unwanted engine vibration broadband frequency range third piezostack mount magnetorheological mount designed manufactured followed installation engine mounting system subsequently effective vibration isolation sliding mode controller robust disturbances system uncertainties designed finally order demonstrate effectiveness proposed new engine mounting system vibration control performances evaluated adopting hardware loop simulation test method associated sliding mode controller vibration control responses presented various engine operating speeds time domain frequency domain found vibration control performance improved engine speed min engine speed min using proposed engine mounting system associated controllers
aim study cross sectionally compare patient reported knee function outcomes people chose non surgical treatment acl injury chose acl reconstruction extracted knee injury osteoarthritis outcome score koos euroqol data entered swedish national acl registry patients non surgically treated acl injury within days injury years injury data compared cross sectionally data collected pre operatively years post operatively age gender matched groups patients primary acl reconstruction year comparisons patients chose surgical treatment reported superior quality life function sports year mean difference points respectively year mean difference points respectively compared chose non surgical treatment patients chose acl reconstruction reported superior outcomes knee symptoms function knee specific health related quality life compared patients chose non surgical treatment
objective given significant costs reduced productivity presenteeism comparison absenteeism overall societal costs presenteeism potentially important role play economic evaluations however costs often excluded objective study review applied cost illness studies economic evaluations identify valuation methods used impact including presenteeism costs practice methods structured systematic review carried explore extent presenteeism applied cost illness studies economic evaluations overall impact including presenteeism overall costs outcomes potential articles identified searching medline psycinfo nhs eed databases standard template developed used extract information economic evaluations cost illness studies incorporating presenteeism costs results total studies included systematic review also demonstrated presenteeism costs rarely included full economic evaluations estimation monetisation methods differed instruments impact disease presenteeism whilst paid work high conclusions potential impact presenteeism costs needs highlighted greater consideration given including economic evaluations cost illness studies importance including presenteeism costs conducting economic evaluation societal perspective emphasised national economic guidelines methodological work required improve practical application presenteeism instruments generate productivity cost estimates
pathophysiological concepts primary headache diseases developed significantly last decades nevertheless pathophysiology single diseases unexplained migraine headache arises activation sensibilization trigeminal nociceptors essential processes located meninges meningeal vessels calcitonin generelated peptide cgrp seems essential importance concerning migraine cluster headache mechanisms leading peripheral central sensitization relevant chronification migraine tension type headache higher level centre hypothalamus seems essential meaning initiation migraine attacks dysbalance sympathetic parasympathetic neural system causes cranial autonomic symptoms headache diseases affected therapeutically
finding meaning life fundamental personal need motivating prosocial behavior fundamental societal need present research tests whether two connected whether helping people increase helpers perceptions meaning life evidence nationally representative data set two experiments support hypothesis participants engaged prosocial behaviors volunteering spending money benefit others reported experiencing greater meaning lives studies study also identifies increased self worth mechanism participants spent money benefit people felt higher personal worth self esteem mediated effect prosocial behavior meaningfulness present results join findings suggesting incentives helping others necessarily depend prospect others reciprocity prosocial behavior incentivized psychological benefits creates prosocial actors
insightful policy rainwater harvesting rwh promoted core adaptation strategy achieving global water security reaching millennium development goals mdgs sustaining water resources microbial chemical quality rwh samples collected tanks sustainable housing development kleinmond south africa monitored results indicated tank water quality within chemical standards cations anions analysed potable water however counts indicator organisms example total coliforms escherichia coli exceeded guidelines stipulated department water affairs forestry microbial analysis results thus indicate tank water fit potable use without treatment social research project conducted describe amongst others condition tank users knowledge rwh system addition demographic data viz gender household size employment status etc gathered order provide socioeconomic background description study population data gathered means face face interviews respondents generally rwh used washing clothes cleaning inside outside houses study noted without acceptance necessary training maintain use tank optimally possible social development projects one kleinmond sustainable
adipokine adiponectin affects multiple target tissues plays important roles glucose metabolism whole body energy homeostasis circulating adiponectin levels obese people lower non obese increased serum adiponectin associated weight loss numerous clinical studies established fat mass positively related bone mass relationship maintained communication two tissues hormones cytokines since adiponectin levels inversely correspond fat mass bone effects potential contribution relationship fat bone investigated clinical observational studies adiponectin found negatively associated bone mineral density suggesting might negative regulator bone metabolism order identify mechanisms underlie activity adiponectin bone large number laboratory studies vitro animal models mice expressing deficient adiponectin carried results studies entirely congruent partly due variation among experimental systems partly due complex nature adiponectin signaling involves combination multiple direct indirect mechanisms
advent smart materials given new dimension field materials science resulting many significant application oriented developments fields engineering piezoelectric material important member smart material family bulk piezo sensors actuators used widely smart structure applications limitation using piezoceramic material bulk form sensors actuators real applications due brittleness nonconformability high temperature processing small area coverage associated ill effects using adhesive bond layer attaching situ piezo transducers covering large area provide good solution circumventing aforementioned problems indigenous development smart conformal piezoceramic coating low process temperature makes suitable silicon batch processing fabrication piezoceramic mems also nondestructive evaluation nde metals composites guided wave based real time structural health monitoring shm chapter presents development application specific situ piezoeceramic coating technical challenges therein
introduction hiv prevention interventions targeting couples efficacious cost effective key strategy preventing hiv transmission awareness full spectrum relationship types underlying complexities well available support mechanisms given context critical design effective couple based interventions objective paper based sub analysis qualitative research study investigating hiv disclosure dynamics amongst pregnant women living hiv durban south africa sub analysis explored nature participants social relationship contexts consequences dynamics women feelings trust towards partners perceptions partner commitment methods june august conducted depth interviews pregnant women living hiv accessing prevention mother child transmission pmtct services durban south africa transcripts coded emergent themes categories using grounded theoretical approach results median age participants years interquartile range years three major themes accompanying sub themes identified relationship types sub themes included unmarried status minimal cohabitation partners presence concurrent relationships relationship quality functioning sub themes included low trust expectation partner commitment relationship turbulence lack communication ability negotiate protective behaviours factors underlying relationship functioning sub themes included dynamics concurrent relationships coinciding concurrent pregnancies gender roles unequal relationship power intimate partner violence threat thereof lack social support conclusions research findings indicate lack many dyadic relationship elements underlying couple counselling frameworks successful risk reduction coordination understanding sexual behaviour accompanying relationship dynamics within different types partnerships crucial optimal design couple based hiv prevention interventions elsevier ltd rights reserved
synthesizing finite state systems full linear time temporal logic ltl ambitious way tackle challenge constructing correct construction systems one particularly promising approach context bounded synthesis originally proposed schewe finkbeiner turn builds upon safraless synthesis described kupferman vardi previous implementations approaches performed computation either explicit way used symbolic data structures binary decision diagrams bdds paper reconsider bdds state space representation use data structure bounded synthesis key construction application two novel optimisation techniques decrease number state bits representation significantly first technique uses signalling bits connect sub games representing safety non safety parts specification second technique based closer analysis step building safety game universal automaton uses sufficient condition remove called counters state space game evaluate approach several benchmark suites show new approach leads computation time improvement several orders magnitude
lipoprotein lipase lpl identified anti hepatitis virus hcv host factor cellular mechanism remains elusive investigated cellular mechanism lpl involving anti hcv functional activation peroxisome proliferator activated receptor ppar alpha signal lpl transducing hepatocytes investigated hcv infected cells primary human hepatocytes hcv core transgenic mice result showed levels transcriptional transactivity nuclear translocation ppar alpha huh cells primary human hepatocytes elevated physiologically ranged lpl treatment either low density lipoprotein hcv particles lpl induced hepatic ppar alpha activation weakened blocking lpl enzymatic activity preventing cellular uptake free unsaturated fatty acids either albumin chelator silencing translocase knockdowns ppar alpha reversed lpl mediated suppression hcv infection furthermore treatment lpl like direct activation ppar alpha reduced levels apolipoproteins involved assembly release hcv virions also alleviated hepatic lipid accumulation induced core protein hcv core transgenic mice exhibited hepatic mir negatively regulates ppar alpha expression wild type controls induction lpl activity fasting core transgenic mice activated ppar alpha downstream target genes involved fatty acid beta oxidation taken together study reveals dual beneficial outcomes lpl anti hcv anti steatosis shed light control chronic hepatitis relation lpl modulators
study designed developed app called ubiquitous physics physics mobile devices like tablet smart phones help students learn principles behind simple pendulum physics unique characteristic physics use sensors mobile devices collect acceleration velocity data pendulum swings data collected transformed facilitate students understanding pendulum time period physics helped students understand effects pendulum mass length angle relation time period addition physics equipped annotation function textual annotation help students interpret understand concepts phenomena simple pendulum physics also generated graphs automatically demonstrate time period pendulum swinging results showed significant positive correlation interpreting graphs applying formula finding indicated ability interpret graphs important role scientific learning therefore strongly recommend physics teachers use graphs enrich students information content understanding negative correlation pair coherence interpreting graphs may participants vocational high school students limited skill confidence physics problem solving often seek help teachers high achieving peers addition findings also indicated physics enhance students achievement week time period hope app globally used learn physics future
lung composed airways lung parenchyma extracellular matrix ecm contains main building blocks components ecm provides physical support stability lung past regarded inert structure recent research provided novel insights revealing ecm also bioactive environment orchestrates cellular responses environs changes ecm airway parenchymal tissues recognized pathological profiles many respiratory diseases including asthma chronic obstructive pulmonary disease copd idiopathic pulmonary fibrosis ipf recently begun investigate whether ecm changes result disease process whether constitute driving factor orchestrates pathological outcomes review summarizes current knowledge alterations ecm asthma copd ipf contributions alterations pathologies emerging data suggest alterations composition folding rigidity ecm proteins may alter functional responses cells within environs change pathological outcomes characteristics highlight potential avenues targeting lung pathologies future may ultimately contribute better understanding chronic lung diseases novel approaches finding therapeutic solutions authors journal pathology published john wiley sons ltd behalf pathological society great britain ireland
examine patterns conduct problems across home school context used latent class analysis analyze primary caregivers teachers ratings conduct problems subscale strengths difficulties questionnaire goodman journal child psychology psychiatry family life project prospective study child development rural small town contexts found similar four class solution years age decreasing prevalence following classes identified low symptoms reported informants low cross context high parent reported symptoms low teacher reported symptoms home context low parent reported symptoms moderate teacher reported symptoms school context high symptoms reported informants high cross context classes exhibited stability age five age seven children likely remain class transition different class longitudinal stability especially high children low cross context class age number child family characteristics measured early childhood executive function verbal ability poverty related risk sensitive parenting parental depressive symptoms associated class membership age five age seven generally associated longitudinal transitions classes
stachys lavandulifolia vahl herbaceous wild plant native iran traditionally used iranian folk medicine mild sedative tea reducing anxiety treatment gastrointestinal disorders previous study ethyl acetate extract lavandulifolia proved anti anxiolytic activity present study designed determine chemical components biologically active fraction extract prepared using maceration method column chromatography medium pressure liquid chromatography mplc used respectively separate fractions finally evaluated fractions used high pressure liquid hplc peak shaving recycle technique achieve purification separated compounds determined using nmr analysis mass spectroscopy six compounds isolated ethylacetate extract aerial parts lavandulifolia including four flavonoids apigenin kumatakenin penduletin dihyroxy trimethoxy flavone labdan diterpenoid labda diol iridoid
software driven assistance elderly impaired people every day life requires integration heterogeneous devices assistive services lack interoperability hampers integration usage devices services furthermore one objective field ambient intelligence human machine interaction adaption assistive services user deeply rooted idea usage ambient technologies still means barrier elderly impaired people prevents trust use technologies technologies aim supporting restricting elderly impaired people methodology needed overcome barrier using ambient assistive technologies paper present approach enable simplified integration heterogeneous devices services web things recommendation lightweight aal ontology together rule based engine called sherlock order demonstrate advantages representing linking user intentions device capabilities using semantic web technologies moreover show semantic representation context aware sherlock engine used derive user intentions recognising device events practical applicability presented approach demonstrated real world use case aicasys project authors published elsevier
three fcc pure metals purity level similar different stacking fault energies sfes respectively processed equal channel angular pressing ecap different temperatures room temperature dislocation density based model improved introducing material dependent parameter improved model utilized predict evolution dislocation density grain size strength materials processed ecap processing predicted dislocation density grain size strength compared experimental results satisfactory agreement influence sfe steady state grain size discussed based experimental modeling results demonstrated homologous temperatures dependence sfe exists reduction sfe leads decrease case recrystallization samples addition increasing deformation temperature leads decrease dislocation densities increase steady state grain size predicted values match well experimental results lower homologous temperatures elsevier rights reserved
developing large smart environment complex task requires collaboration experts different disciplines successfully attain collaboration trivial matter paper illustrates problem case study manager facility intends influence pedestrians choose task requires certain effort using staircases instead current one requires less effort using elevator defining requirements scenarios requires strong multidisciplinary collaboration currently well supported paper contributes approach provide non technician experts tools provide feedback requirements verify systematic way
myofibroblasts primary effector cells mediate matrix remodeling pulmonary fibrosis rapidly assemble extracellular fibronectin matrix tensin tns key component specialized cellular adhesions fibrillar adhesions bind extracellular fibronectin fibrils hypothesized tns may play role modulating myofibroblast mediated matrix formation found tns expression increased fibroblastic foci lungs idiopathic pulmonary fibrosis transforming growth factor tgf beta profoundly regulates tns expression kinetics parallel expression myofibroblast marker smooth muscle actin tgf beta induced tns expression dependent signaling tgf beta receptor rho coiled coiled kinase actin megakaryoblastic leukemia serum response factor dependent small interfering rna mediated knockdown tns disrupted tgf beta induced myofibroblast differentiation without affecting tgf beta smad signaling contrast loss tns resulted disruption focal adhesion kinase phosphorylation focal adhesion formation actin stress fiber development finally tns essential formation fibrillar adhesions assembly nascent fibronectin collagen matrix myofibroblasts summary data show tns novel megakaryoblastic leukemia dependent gene induced pulmonary fibrosis tns plays essential role tgf beta induced myofibroblast differentiation myofibroblast mediated formation extracellular fibronectin collagen matrix targeted disruption tns associated signaling may provide avenue inhibit tissue fibrosis
electrical networks across globe gearing towards environmentally friendly operation many renewable sources introduced among popularity electrical generation wind gained ground wind one meteorological conditions also high influence line ratings manner operating line known dynamic thermal rating dtr system seeing relationship intuitively important investigate reliability electrical network incorporating dtr wind farm hence objective paper propose methodology perform task methodology sequential monte carlo smc simulation performed due time dependencies line ratings wind power result modeling time series data performed using auto regressive moving average arma model moreover correlations line rating wind power also considered provide practical approach modeling results shown dtr system able increase network reliability allows higher wind energy penetration
second fourth grade students read storybook described typical boy interacted obese boy one four reasons sympathy curiosity teacher instructed reason explore manner typical storybook character reason associating obese storybook character influences children responses characters results revealed children responded favorably obese storybook character learning typical storybook character association especially typical storybook character reason association presented internally motivated sympathy curiosity contrast stigma association findings reported prior research children also responded favorably typical storybook character association obese storybook character
study aimed assess whether showing emotion organizational inquiry failure affects perceptions truthfulness function match explanation caused failure emotion expressed two web based studies conducted participants work experience saw videos inquiry rated protagonist truthfulness studies protagonists expressed emotion anger shame rated less truthful protagonists expressed emotion regardless failure attributed order confound effects emotions occupational stereotype effects male protagonists shown showing emotions questioned normal managers aware tendency count employee research focusing effects showing emotions perceptions truthfulness organizational context
background amager project initiated quasi experimental study based active outreach suicide preventive intervention inspired norwegian baerum model year follow study conducted randomized controlled trial showing kind active outreach suicide attempters significant preventive effect prevalence suicide attempts significantly reduced number patients repeating suicide attempt aims year rct follow aim investigate sustainability suicide preventive effect shown year follow study method one hundred thirty three suicide attempters included year follow rct study copenhagen university hospital amager randomized rapid outreach suicide preventive intervention opac tau results offering opac intervention patients suicide attempt significant preventive effect total suicide attempts significantly reduces number patients repeating suicide attempt suicide preventive effect lasts weeks years effect number patients repeating suicide attempt longer sustainable effect number repetitive events remains significant conclusion study emphasizes importance rapid active outreach intervention points effect number patients repeating suicide attempt wears longer sustainable years suggesting need follow intervention
psychopathy considered one best predictors violence prison misconducts arguably important clinical construct correctional setting however tested whether psychopathy used predict misconducts prison environments women done men date studies exist examine validate association female offender samples present study included ethnically diverse female offenders aim prospectively predict violent nonviolent misconducts month period using official records prior violent criminal history homicide manslaughter assault self report measures psychopathy impulsivity empathy using negative binomial regression found past violent criminal history callous antisocial psychopathic traits predictors violent misconducts whereas antisocial psychopathic traits impulsivity best predicted nonviolent misconducts although empathy negatively associated psychopathy significant predictor violent nonviolent misconducts statistical models included impulsivity considered parsimonious predicting misconducts findings demonstrate risk factors found reliable male offender samples psychopathic traits impulsivity past violent criminal history generalize female offenders predicting nonviolent violent misconducts one notable difference importance callous psychopathic traits predicting chronic violent misconducts female offenders sum similarities psychopathy impulsivity differences prediction misconducts among men women
objective oncology nursing stressful nature nurses field experience high amount stress burnout order cope occupational stress nurses need employ flexible adjustment mechanisms allow power process experiences failure efficient stress management causes burnout burnout closely related powerlessness therefore believed occurrence burnout reduced means psychological empowerment nurses study conducted determine effect psychodrama based psychological empowerment program perception empowerment levels burnout oncology nurses method sample made oncology nurses nurses study group control comparison group study data collected using psychological empowerment scale nurse work empowerment scale maslach burnout inventory study group attended psychodrama based psychological empowerment program hours day week weeks data assessment employed independent test one way analysis variance results psychological empowerment workplace empowerment scores nurses study group increased burnout scores decreased following attendance psychodrama based psychological empowerment program significance results found psychodrama based psychological empowerment program increased psychological empowerment enhanced perception workplace empowerment decreasing levels burnout oncology nurses program recommended allow oncology nurses benefit personal experiences thus increase self empowerment enhance perception empowerment prevent burnout
aim study assess performance computer aided semi automated algorithm adapted purpose segmenting malignant pleural mesothelioma mpm forty five scans collected patients mean age years multi centre clinical drug trial computer aided random walk based algorithm applied segment tumour results compared radiologist drawn contours correlated measurements made using mpm adapted response evaluation criteria solid tumour modified recist mean accuracy sorensen dice index achieved compared median measurement time min range manual delineation median running time algorithm min range linear correlation pearson correlation coefficient established changes modified recist computed tumour volume volumetric tumour segmentation offers potential solution challenges quantifying mpm computer assisted methods one presented study facilitate accurate time efficient manner provide additional morphological information tumour evolution time
sustainable green building practices adopted higher education institutions new campus buildings major renovations daily operations paper provides synthesis opinions existing practices related water conservation institutional green buildings member institutions appa formerly association physical plant administrators specific focus regarding waterless urinals operation attempted web based survey follow one one interviews utilized extract information data industry professionals survey evaluated institution use policy related sustainable building practices focused approaches water conservation regional preferences provided barriers water conservation practices approaches identified operational challenges evident particularly relate waterless urinals clear higher education institutions engaging water conservation practices across canada united states work contributes foundation future research analysis related best management practices water conservation higher education sector
paper focuses parameter uncertainty quantification specific absorption rate sar calculation using computer aided design mobile phone model uncertainty sar calculation quantified three nonintrusive methods unscented transformation stochastic collocation nonintrusive polynomial chaos performances cases one two random variables analyzed simplify procedure case multiple uncertain inputs demonstrated uncertainties combined evaluate parameter uncertainty output quantify relative importance uncertain input parameter respect uncertainty output polynomial chaos based sobol indices method used sar calculation sensitivity analysis results investigations presented discussed
background chondromalacia patellae common disorder although magnetic resonance imaging mri widely used investigate patellar cartilage lesions descriptive mri based grading system chondromalacia patellae purpose propose new mri grading system chondromalacia patellae corresponding high resolution images might useful precisely reporting comparing knee examinations routine daily practice used predicting natural course clinical outcome patellar cartilage lesions material methods high resolution fat saturated proton density images axial plane corresponding mapping images reviewed detailed mri grading system covering deficiencies existing gradings set presented images two experienced observers blinded clinical data examined knee images evaluated patellar cartilage changes according proposed grading system inter intra rater validity testing using kappa statistics calculated results descriptive detailed grading system corresponding mapping images presented inter rater agreement confidence interval intra rater agreements observer observer values conclusion present new mri grading system chondromalacia patellae corresponding images good interand intra rater agreement might useful reporting comparing knee mri examinations daily practice may also potential using precisely predicting prognosis clinical outcome patients
multiple system atrophy fatal sporadic adult onset neurodegenerative disorder symptomatic disease modifying treatment available cytopathological hallmark multiple system atrophy accumulation alpha synuclein aggregates oligodendrocytes forming glial cytoplasmic inclusions impaired insulin insulin like growth factor signalling igf insulin resistance decreased insulin igf reported neurodegenerative disorders alzheimer disease increasing evidence also suggests impaired insulin igf signalling multiple system atrophy corroborated increased insulin igf plasma concentrations multiple system atrophy patients reduced igf brain levels transgenic mouse model multiple system atrophy tested hypothesis multiple system atrophy associated brain insulin resistance showed increased expression key downstream messenger insulin receptor substrate phosphorylated serine residue neurons oligodendrocytes putamen patients multiple system atrophy furthermore expression insulin receptor substrate irs phosphorylated serine residue apparent inclusion bearing oligodendrocytes putamen contrast different groups temporal cortex less vulnerable structure compared putamen findings suggest insulin resistance may occur multiple system atrophy regions neurodegenerative process severe point possible relation alpha synuclein aggregates insulin resistance also observed insulin resistance striatum transgenic multiple system atrophy mice demonstrate glucagon like peptide analogue exendin well tolerated federal drug agency approved antidiabetic drug positive effects insulin resistance monomeric alpha synuclein load striatum well survival nigral dopamine neurons additionally plasma levels exosomal neural derived irs phosphorylated serine residue corresponding serine residue humans negatively correlated survival nigral dopamine neurons multiple system atrophy mice treated exendin finding suggests potential developing peripheral biomarker candidate objective outcome measure target engagement clinical trials glucagon like peptide analogues multiple system atrophy conclusion observation brain insulin resistance multiple system atrophy patients transgenic mice together beneficial effects glucagon like peptide agonist exendin transgenic mice paves way translating innovative treatment clinical trial
monitoring distress assessment cancer patients treatment phase component good quality care practice yet dearth prospective studies examining distress attempt begin filling gap inform clinical practice conducted prospective longitudinal study examining changes distress anxiety depression problems living age gender roles age gender predicting distress newly diagnosed brazilian cancer patients assessed three time points chemotherapy age gender identified first day chemotherapy anxiety depression problems living self reported planned midway point last day chemotherapy patients reported clinically significant levels anxiety depression respectively prevalence reduced anxiety depression years female patients reported greater emotional physical family problems male counterparts patients elevated levels distress noted beginning treatment subsided time treatment completion however middle aged female patients continued report heightened distress evidence based psychosocial intervention offered risk patients early phases treatment may provide distress relief improve outcomes illness trajectory preventing psychosocial physical morbidity due untreated chronic distress
background gonadal steroids may modulate disease course multiple sclerosis objective assess prevalence clinical associations hypogonadism men methods male patients aged years relapsing remitting rrms clinically isolated syndrome cis first symptom years prior selected longitudinal clinical study measured hormones stored morning blood samples collected expanded disability status scale edss scores every months symbol digit modalities test sdmt results annually results analysis included men mean age years edss disease duration years men hypogonadal total testosterone none showed compensatory elevations luteinizing hormone low testosterone levels testosterone estradiol ratios negatively correlated body mass index bmi leptin showed correlation hydroxy vitamin levels primary cross sectional analyses negative age adjusted correlation total testosterone edss age adjusted longitudinal analyses higher baseline testosterone levels associated less decline sdmt conclusions men may experience hypogonadotropic hypogonadism low testosterone levels may associated worse clinical outcomes potential neuroprotective role testosterone warrants investigation
advanced grammar courses often present standardized grammar rules students without considering sociolinguistic variation result many native heritage students feel speak incorrectly many second language learners get accurate picture target language real world grammar article describes evaluates unique approach teaching advanced spanish grammar university students curriculum focuses core grammatical content studying structures subject sociolinguistic variation habia approximate habian dos ranas approximate two frogs highlights sociopolitical factors explain forms deemed prestigious test efficacy curriculum students enrolled advanced spanish grammar course large university southwestern united states completed pre posttest measured spanish grammar knowledge awareness sociolinguistic concepts positive language attitudes results showed statistically significant gains respect knowledge grammar sociolinguistics students also demonstrated heightened awareness prejudice manifest judgments spoken language
tau microtubule binding protein important stability neuronal axons normally expressed within neurons also secreted brain interstitial fluid communicates freely cerebrospinal fluid csf restricted manner blood via glymphatic clearance system brain alzheimer disease neuroaxonal degeneration results increased release tau neurons furthermore tau truncated phosphorylated leads aggregation tau neurofibrillary tangles proximal axoplasm neuroaxonal degeneration tangle formation reflected increased concentrations total tau tau measured using assays detect forms tau phospho tau tau measured using assays antibodies specific phosphorylated forms tau csf tau tau concentrations increased stroke cns disorders neuroaxonal injury without tangles tau selectively increased whereas tau concentration often stays normal tauopathies diseases neurodegeneration neurofibrillary tangles csf tau tau concentrations typically unaltered puzzling result warrants investigation current review discuss association tau tau concentrations body fluids neuropathological changes imaging findings clinical features cns diseases search reliable biomarkers neurodegenerative diseases active field important diagnosis monitoring disease progression treatment response focussed review professor zetterberg considers association total tau phospho tau body fluids neuropathology imaging clinical features alzheimer disease neurodegenerative diseases
work presents methodology internal combustion engine ice waste heat recovery organic rankine cycle orc system though jacket waster heat usually ignored due low temperature contained thermal energy roughly exhaust gas ice certain rated loads makes recovery energy subject interest cascade utilization exhaust gas jacket water heat single loop orc systems investigated compared system recovers exhaust gas heat system performances evaluated thermal efficiency waste heat recovery efficiency improvement ice efficiency calculated heat exchanger capacity validated different ice load conditions results show highest thermal efficiency reached using full recovery exhaust gas heat yields highest waste heat recovery efficiency improvement ice efficiency preheaters evaporators operated high evaporating pressure may heat exchanger capacity lower calculated heat amount ice part load conditions therefore essential validate calculated heat exchanger capacity real operating conditions elsevier ltd rights reserved
electricity security generally referring system capability provide electricity users multi faceted problem attracting mounting attention policy makers scientists around world electricity security encompasses largely different properties based upon time geographical scales factors affecting electricity delivery challenged threats surfacing spheres far beyond physical one involves myriad stakeholders spanning manifold disciplines considerably different expectations electricity commodity services studied complicated techno economic problem complex socio economic problem reasons framework changing european union global energy scenarios render electricity security ever challenging assess critical safeguard background work presents recommendations bring science policy making closer towards evaluating handling electricity security detail done characterising electricity security via features cross roads policy science reviewing electricity security modelling assessment approaches across sectors proposing elements novel electricity security decision analytic framework contextualising proposed framework energy union grid design initiatives
machine design machine building closely related relationship two intertwined theory condition machine building based machine design daily work make machine building smoothly implemented must carried based condition machine design important part machine building machine design order improve performances mechanical products guarantee reliability quality machines must good design production mechanical products technological theory two models production complement preconditions
buildings major impact environment excessive use resources energy water large carbon dioxide emissions paper revisit previously published study economics environmentally sustainable buildings estimate effect green building practices market rents use new matching methods take advantage clustered structure buildings data propose general framework matching observational studies specific matching methods within framework simultaneously achieve three goals maximize information content matched sample cases also minimize variance difference means effect estimator form matches using flexible matching structure one many many one structure iii directly attain covariate balance specified matching investigator knowledge existing matching methods able achieve two goals simultaneously also unlike matching methods proposed methods require estimation propensity score dimensionality reduction techniques although proposed methods used additional balancing covariates context iii using matching methods find green buildings higher rental rates per square foot otherwise similar buildings without green ratings moderately larger effect one found prior study
paper describes parallel elastic elements used reduce energy consumption electric motor driven fully actuated sandia transmissionefficient prototype promoting research steppr bipedal walking robot without compromising significantly limiting locomotive behaviors physically motivated approach used illustrate selectively engaging springs hip adduction ankle flexion predict benefits three different flat ground walking gaits human walking humanlike robot walking crouched robot walking based locomotion data springs designed substantial reductions power consumption demonstrated using bench dynamometer lessons applied steppr fully actuated bipedal robot designed explore impact tailored joint mechanisms walking efficiency featuring high torque brushless motors efficient low ratio transmissions high fidelity torque control steppr provides ability incorporate novel jointlevel mechanisms without dramatically altering high level control unique parallel elastic designs incorporated steppr walking data show hip adduction ankle flexion springs significantly reduce required actuator energy joints several gaits results suggest parallel joint springs offer promising means supporting quasi static joint torques due body mass walking relieving motors need support torques substantially improving locomotive energy efficiency
aim around one third patients crohn disease affected crohn fistula ano pcd typically follows chronic course patients undergo longterm medical surgical therapy set describe current surgical practice management pcd method survey surgical management pcd designed expert group colorectal surgeons gastroenterologists assessed acute elective multidisciplinary definitive surgical management pilot questionnaire undertaken meeting digestive disease federation survey refined distributed nationally trainee collaborative networks results national rollout obtained responses surgeons approached response rate first operation surgeons would always consider drainage sepsis would place draining seton first elective operation would routinely insert draining seton would avoid cutting seton ibd multidisciplinary team available respondents although routinely discussed pcd patients anti tumour necrosis factor alpha therapy routinely considered although left medical management gastroenterologists common definitive procedures removal seton fistulotomy advancement flap fistula plug ligation intersphincteric track lift procedure indications diverting stoma proctectomy intractable sepsis incontinence poor quality life conclusion survey demonstrated areas common practice also highlighted divergent practice including choices definitive surgery multimodal management practical guidelines required support colorectal surgeons
psoriasis resistant treatment shows frequent relapse systemic treatment often associated toxicities long term safety data lacking newer drugs like biologics moreover body areas hands feet intertriginous areas scalp nails even resistant frequently systemic treatments necessary considering higher psychological impact patient lack agreement best therapeutic modalities management psoriasis involving difficult treat locations present indian guidelines conditions available literature reviewed extensively treatment psoriasis involving difficult treat locations level evidence evaluated per oxford centre evidence based medicine guideline therapeutic suggestions developed best care employed consider socioeconomic cultural genetic ethnic factors prepare therapeutic suggestion appropriate logical used among indian population people similar ethnic socioeconomic background
many pseudorandom sequence generators stream ciphers based linear feedback shift registers dynamic feedback dlfsr order increase period linear span sequences paper study different modes operation dlfsr structure propose general classification generators attending way feedback applied theoretical study modes operation allows identify optimal ones recent dlfsr proposals identified particular elements classification proposed new generic pseudorandom sequence generator belonging one optimal classes presented
supply chain management critical domain fast moving consumer goods fmcgs domain known complexity new standards regulations regarding energy efficiency environmental aspects general well customer demand make analysis modeling design supply chain complicated partners involved processes numerous diverse background help solving problem common understanding domain exchange information among partners involved supply chain high importance ontology capturing knowledge domain created achieve maximum efficiency domain operations terms cost quality service environmental impact concept definitions multiple sources gathered advanced software solution leverages semantic web technologies enables users link data multiple excel spreadsheets relational databases together real time data collection collaboration reporting framework new way collaboration throughout supply chain use underlying ontology semantic technologies visualization technics introduced proposed approach applied context european project save authors published elsevier ltd
paper fractional order system observability discussed representation systems involves classical linear integer system system described parabolic equation used define system real state conclude system state approximately observable however also shown pseudo state space representation usually encountered literature fractional systems used design luenberger like observers permits estimation important variables system observer finally used order estimate temperature thermal system temperature measure different abscissa
image intensifier installed optical path compact spectrometer may act fast gating unit widely used time resolved measurements also variable attenuator amplifier continuous wave mode opens possibility automatic gain control new feature spectroscopy user relieved necessity manually adjust signal level certain value done automatically means electronic feedback loop even important automatic gain control done without changing exposure time additional benefit time resolved experiments concept algorithm design considerations experimental results presented
work present virtual assistant help instructors offer individualized practical training controller design linear systems virtual assistant designed used together goodle gms web application offers services collection storage automatic grading students exercises using proposed scheme instructor generate easy way without knowledge programming individualized exercises graded automatically ensuring exercises solution tine degree difficulty platform bear tested automatic control course university seville academic year ifac international federation automatic control hosting elsevier ltd rights reserved
fermented chinese formula shuan tong ling composed radix puerariae gegen salvia miltiorrhiza danshen radix curcuma jianghuang hawthorn shanzha salvia chinensis shijianchuan sinapis alba baijiezi astragalus huangqi panax japonicas zhujieshen atractylodes macrocephala koidz baizhu radix paeoniae alba baishao bupleurum chaihu chrysanthemum juhua rhizoma cyperi xiangfu gastrodin tianma whose aqueous extract fermented lactobacillus bacillus aceticus saccharomycetes shuan tong ling formula used treat brain diseases including ischemic stroke migraine vascular dementia shuan tong ling attenuated induced oxidative stress rat microvascular endothelial cells however potential mechanism involved effects poorly understood rats intragastrically treated shuan tong ling days middle cerebral artery occlusion induced results indicated shuan tong ling cerebral protective effect reducing infarct volume increasing neurological scores shuan tong ling also decreased tumor necrosis factor alpha interleukin beta levels hippocampus ischemic side addition shuan tong ling upregulated expression sirt bcl downregulated expression acetylated protein bax injection silent information regulator sirt inhibitor subarachnoid space every days four times reversed changes results demonstrate shuan tong ling might benefit cerebral ischemia reperfusion injury reducing inflammation apoptosis activation sirt signaling pathway
patients alzheimer disease show cognitive behavioral disorders caregivers difficulties cope daily life psychological symptoms seem increased impaired emotion processing patients ability linked social cognition thus essential maintain good interpersonal relationships non verbal emotion processing genuine way communicate especially patients whose language may rapidly impaired many studies focus emotion identification patients mostly means facial expressions rather emotional prosody even fewer consider emotional prosody production despite playing key role interpersonal exchanges literature subject scarce contradictory results present study compares performances patients yrs mmse control subjects yrs mmse tasks emotion identification faces voices non linguistic vocal emotion emotional prosody task emotional prosody production sentences pronounced neutral positive negative tone context read alzheimer disease patients showed weaker performances control subjects emotional recognition tasks particularly identifying emotional prosody negative relation identification scores npi professional caregivers scores found underlines link psychological behavioral disorders production emotional prosody seems relatively preserved mild moderate stage disease found subtle differences regarding acoustic parameters qualitative way judges established patients productions good control subjects results suggest interesting new directions improving patients care
amifostine aminopropyl aminoethyl phosphorothioate broad spectrum cytoprotective agent used treat nuclear radiation chemical weapon injuries recently amifostine shown profound biological influence tumor cells examine effects mechanisms underlying effects amifostine human acute megakaryocytic leukemia evaluated efficacy amifostine dami cells observed cell cycle arrest phase amifostine treatment also induced cell apoptosis dami cells corresponds formal studies whole genome microarray bioinformatics analyses found amifostine affected gene expression ccnd bcl casp revealed mechanism amifostine acted dami cells thus ccnd bcl gene network predicted direct target amifostine treating human acute megakaryocytic leukemia may provide novel potential target therapy several subtypes human aml
runners greater prevalence knee osteoarthritis nonrunners hypothesis joint loads running cause forwarded two mechanisms proposed cumulative load surprisingly low running important risk peak load running conditions cartilage withstand mechanical stresses running
background motor retardation cardinal feature adult depression limited information exists motor activity depressed children present study evaluated motor activity depressed children compared controls investigated whether motor activity linked severity symptoms depressed children method motor activity day night time recorded actigraphy twenty two depressed children controls sads interview child mother used diagnose depression depressed children filled child depression inventory cdi self report severity depression parents teachers depressed children controls filled child behavior checklist cbcl teacher report form trf results motor activity reduced daytime depressed children compared controls depressed children spent time total immobility night time peers depressed children motor activity linked severity self teacher reported symptoms depressed children suicidal ideation differed significantly motor activity compared depressed children without suicidal ideation controls limitations sample size moderate conclusions reduced motor activity important feature childhood depression objectively measured motor activity distinguish depressed children peers motor retardation linked severity depression especially suicidal ideation possibly subtype depressed children groups different etiology treatment needs course illness elsevier rights reserved
aim impaired autonomic function could mechanism development cardiometabolic diseases obesity hence simple anthropometric measures overall central obesity could screening markers autonomic imbalance analysed relationship heart rate variability hrv parameters obesity indicators methods sixty three obese women underwent blood pressure lipids anthropometric measurements body composition assessment homa homeostasis model assessment index calculation short term hrv analysis results correlation obesity indicators hrv parameters influenced age multiple regression model sagittal abdominal diameter sad significant negative predictor lnlf logarithmically transformed ratio low high frequencies lnlfnorm positive predictor hfnorm normalized high frequencies significant relationship remained even adjustment age homa blood pressure lipid profile menopause body mass index bmi body fat percentage fat anterior forearm skinfold showed inverse association hrv correlation waist circumference waist height ratio whtr lnlf well anterior thigh skinfold lnlf lfnorm normalised low frequencies hfnorm lost adjustments conclusion among anthropometric measures sad anterior forearm skinfold thickness showed highest predictive ability hrv markers lower sympathetic higher cardiac parasympathetic activity corresponded indicator central obesity indicators peripheral obesity showed completely opposite relationship markers cardiac autonomic activity
previously reported selective ablation nuclear receptors retinoid receptor rxr alpha rxr beta mouse epidermal keratinocytes rxr beta topical application active vitamin trans retinoic acid wild type mouse skin induces human atopic dermatitis like phenotype triggered increased expression thymic stromal lymphopoietin tslp proinflammatory cytokine demonstrate epidermal keratinocytes unliganded heterodimers vitamin receptor vdr rxr alpha retinoic acid receptor gamma rar gamma rxr beta bound repressing complexes cognate dna binding sequence dbs tslp promoter regulatory region treatments either agonistic analog dissociate repressing complexes recruit coactivator complexes rna polymerase thereby inducing transcription furthermore identified several functional kappa activator protein stat smad dbs tslp promoter region interestingly many transcription factors dbs present tslp promoter region differentially used intestinal epithelial cell iec collectively study reveals vivo within heterodimers rxr rar isotypes functionally redundant also unveils combinatorial mechanisms involved tissue selective regulation tslp transcription epidermal keratinocytes iec
rough set theory provides powerful tool dealing uncertainty data application variety rough set models mining data stored single table widely studied however analysis data stored relational structure using rough sets still extensive research area paper proposes compound approximation spaces constrained versions intended handling uncertainty relational data proposed spaces expansions tolerance approximation ones relational case compared compound approximation spaces constrained version enables derive new knowledge relational data proposed approach improve mining relational data uncertain incomplete inconsistent elsevier inc rights reserved
articular cartilage damage osteoarthritis common joint diseases joints prone damage caused sports injuries aging damage regularly progresses serious joint disorders including osteoarthritis degenerative disease characterized thinning eventual wearing articular cartilage ultimately leading joint destruction osteoarthritis affects millions people worldwide current approaches repair articular cartilage damage include mosaicplasty microfracture injection autologous chondrocytes treatments relieve pain improve joint function long term results unsatisfactory long term success cartilage repair depends development regenerative methodologies restore articular cartilage near native state two promising approaches implantation engineered constructs mesenchymal stem cell msc seeded scaffolds delivery appropriate population mscs direct intra articular injection mscs may used trophic producers bioactive factors initiating regenerative activities defective joint current challenges msc therapy need overcome current limitations cartilage cell purity vitro engineer tissue structures exhibiting required biomechanical properties review outlines current status mscs used cartilage tissue engineering cell therapy seeking repair articular cartilage defects related problems msc based technologies show promise used repair cartilage defects joints
single definition polypharmacy use medications commonly used alternative quantitative definition use medications clinically indicated use unnecessary harmful prescribing proposed protocols algorithms improve polypharmacy prescribing older adults developed american geriatrics society ags beers criteria screening tool older people prescriptions stopp explicit criteria reflect elements common across protocols algorithms concepts ags beers stopp incorporated polypharmacy reduction strategies improve outcomes care older adults
based relevant theory gas discharging numerical model gas discharge tube established help particle simulation method physical mechanism producing plasma gas discharge relationship gas ignition voltage gas pressure electrode distance product studied computer simulation physical process producing plasma neon discharge simulated result exact accordance theoretical analysis provides feasible way study plasma stealth technology
hybrid electric vehicle hev drive trains electrical generator coupled onto shaft internal combustion engine ice order process either entire given fraction traction power required vehicle wheels ice driven generator confined within vehicle hood exposed heating resulting ice operation high compactness totally enclosed construction suitable machine cooling arrangement become challenging targets generator design must deal due unique characteristics higher torque per volume higher efficiency compared machine topologies axial field permanent magnet machine afpm topology selected development rev min rated generator prototype would utilized demonstrator hev drive train paper describes original solutions adopted design hev generator reports experimental results taken prototype machine
stress corrosion cracking scc common failure mechanism characterized slow environmentally influenced crack propagation structural components mechanisms proposed explain microscopic scale cracking propagation processes able elucidate aspects phenomenon different metal environment systems work concerned development new multiphysics model understanding phenomena crack propagation effect scc new model based upon phase field method based variational formulation brittle fracture regularized approximation discontinuities robust algorithm capable prescribe displacements boundary small sub volume crack onset obtained image processing based digital image correlation sample numerical simulations iii coupling diffusion model informed first principles computations diffusion coefficient new model phenomenon environmentally assisted cracking phenomena successfully represented well interactions cracks subsequent shielding effects analyses performed several samples inconel alloy containing crack network show remarkable agreement crack morphology history obtained model experiments elsevier ltd rights reserved
paper presents results experimental analytical investigations behavior gfrp pipes used water supply pipeline systems pipes consist two filament wound outer gfrp tubes polymer mortar tubes parallel plate loading tests conducted test results compared predicted results load deflection prediction conducted analysis conventional strength materials approach shown results obtained experiment analysis agreed well
psoriatic patients systemic inflammation well oxidative stress associated cardiovascular disorders atherosclerosis hypertension myocardial infarction stroke psoriasis also shown associated kidney disease several studies disorders also strong component oxidative stress usually emanates nadph oxidases noxs inducible nitric oxide synthase inos however whether psoriatic inflammation leads renal oxidative stress dysfunction remains unexplored therefore study investigated effect imiquimod imq induced psoriatic inflammation kidney function inflammation murine model mice topically applied imq followed various analyses kidney blood related inflammation kidney function psoriatic inflammation mice associated kidney dysfunction reflected increased serum creatinine blood urea nitrogen kidney dysfunction paralleled upregulation ros generating enzymes nox nox inos concomitant oxidative stress treatment either general antioxidant acetyl cysteine nox inos inhibitors led improvement imq induced renal dysfunction oxidative stress contrary buthionine sulfoximine oxidant inducer aggravated imq induced renal impairment oxidant antioxidant imbalance data suggest psoriatic inflammation causes kidney dysfunction noxs inos play important roles treatment antioxidants may considered adjunct therapy psoriatic patients kidney disease elsevier rights reserved
intestinal inflammation induced dextran sodium sulfate dss used study acute chronic ulcerative colitis animal models decreased gut tissue anti inflammatory cytokine concentration mrna abundance associated development chronic bowel inflammation twelve piglets days old fitted intragastric catheter randomly allocated control dss groups administrating either sterile saline dss body weight saline per day respectively days growth rate food conversion efficiency reduced dss piglets compared control group quantitative histopathological grading inflammation jejunum colon collectively showed dss treatment resulted fold greater inflammation severity scoring colon jejunum indicative chronic ulcerative colitis colon upper gut permeability endpoint fold higher dss group compared control group dss group higher concentrations mrna abundances tnf alpha jejunal colonic tissues compared control group colonic concentration mrna abundance reduced however jejunal mrna abundance increased dss group compared control group conclusion administration dss days respectively induced acute inflammation jejunum chronic inflammation ulcerative colitis colon substantially decreased colonic concentration mrna abundance young pigs mimicking expression pattern humans associated chronic bowel inflammation
reverse routing used transfer flood pollution related information monitored downstream gauging station ungauged upstream cross section signal identification problem ill posed sensitive perturbations data inverted therefore amplification errors befalling measurements must controlled storage routing models parsimonious diffusion wave substitutes well suited conversion direct reverse routers present efficient inversion frameworks based lag route single reservoir plus exact reverse lag step reservoirs series models cases invert centred finite difference scheme reservoir storage balance equation involves one value unknown signal signal values identified previous reverse time steps would carry perturbations absent simple structure endows reverse scheme robustness procedures verified perfect error seeded data solution oscillations caused latter damped low pass filtering inverse routing models regain upstream signals high fidelity reverse storage routing exemplified demonstration reservoir control field case solute transport stream
given volunteers perform diverse range behaviors aimed helping distinct causes nuanced understanding types volunteer behaviors similar different would enrich basic applied perspectives volunteerism created validated inventory individuals interests eight different types volunteering administrative volunteering helping animals interpersonal helping autonomy dependency donating physical volunteering built natural environments political volunteering grouping eight types positions two general categories interpersonal skills based volunteer positions also examined convergent discriminant validity linking interest positions constructs volunteerism literature prosocial personality volunteer motivations volunteer satisfaction research demonstrates volunteer behaviors classified types certain individuals interested different types volunteer behaviors volunteers engaged behaviors match interests express greater volunteer satisfaction
logic based approaches legal problem solving model rule governed nature legal argumentation justification legal discourse suffer two key obstacles absence efficient scalable techniques creating authoritative representations legal texts logical expressions difficulty evaluating legal terms concepts terms language ordinary discourse data centric techniques used finesse challenges formalizing legal rules matching legal predicates language ordinary parlance exploiting knowledge latent legal corpora however techniques typically opaque unable support rule governed discourse needed persuasive argumentation justification paper distinguishes representative legal tasks approach appears particularly well suited proposes hybrid model exploits complementarity
objectives study determine behavioral molecular responses adult zebrafish danio rerio central nervous system cns following dietary exposure pesticide dieldrin zebrafish fed pellets spiked dieldrin days behavioral analysis revealed difference exploratory behaviors related anxiety transcriptional networks cell aggregation selection decreased expression suggesting immunosuppressive effect dieldrin consistent studies investigating organochlorine pesticides processes related oxidative phosphorylation also differentially affected dieldrin quantitative proteomics itraq using hybrid quadrupole orbitrap identified proteins different following one doses proteins included atp synthase subunits mitochondrial hypoxia regulated protein decreased nadh dehydrogenases mitochondrial signal recognition particle regulated thus proteins affected functionally associated mitochondria protein network analysis implicated parkinson disease huntington disease diseases associated altered proteins molecular networks related mitochondrial dysfunction cell regulation hypothesized underlie association dieldrin data contribute comprehensive transcriptomic proteomic biomarker framework pesticide exposures neurodegenerative diseases biological significance dieldrin persistent organochlorine pesticide associated human neurodegenerative disease parkinson disease dieldrin ranked agency toxic substances disease registry continues pesticide concern human health transcriptomics quantitative proteomics itraq employed characterize molecular networks central nervous system altered dietary exposure dieldrin found transcriptional protein networks related immune system mitochondria parkinson disease preferentially affected dieldrin study provides new insight mechanisms dieldrin neurotoxicity may explain part association pesticide increased risks neurodegeneration data contribute significant way developing molecular framework pesticide induced neurotoxicity elsevier rights reserved
growing clinical evidence support diet irritable bowel syndrome ibs low fermentable oligosaccharides disaccharides monosaccharides polyols fodmap low fodmap diet gaining acceptance globally among clinicians ibs sufferers alike however disparity concerning success rates fodmap diet patients attributed differences recommended diet adherence issues address differences diet generally accepted science based definition analytical criteria low fodmap products suitable low fodmap diet developed address adherence challenge regulators permit manufacturers low fodmap products communicate benefits low fodmap diet product labels promotional material facilitate people ibs selection use low fodmap foods
testosterone thought positively associated mating effort initiation establishment sexual relationships wingfield yet testosterone negatively associated nurturance van anders high levels testosterone may incompatible relationship maintenance instance partnered men high testosterone report lower relationship quality compared partnered men low testosterone booth dabbs findings women inconsistent however even less known potential dyadic associations testosterone relationship quality couples current report assessed relationship satisfaction commitment investment heterosexual couples tested hypothesis aspects relationship quality would negatively associated individual partner testosterone levels found testosterone fact negatively associated relationship satisfaction commitment men women also evidence dyadic associations participants satisfaction commitment negatively related partners levels testosterone associations larger women men testosterone findings consistent idea high testosterone may incompatible maintenance nurturant relationships current findings also provide first evidence dyadic associations testosterone relationship quality couples highlighting interdependent nature close relationship processes importance considering interdependence social neuroendocrine research published elsevier inc
advances computer internet technologies allowed health care providers develop use test various types web based interventions practice research indeed increasing number web based interventions recently developed tested health care fields despite great potential web based interventions improve practice research little known current status web based interventions especially related menopause identify current status web based interventions used field menopause literature review conducted using multiple databases keywords online internet web intervention menopause using keywords total eligible articles analyzed identify current status web based interventions menopause six themes reflecting current status web based interventions menopause identified existed web based intervention studies menopause web based decision support systems mainly used lack detail interventions lack guidance use web based interventions counselling frequently combined web based interventions pros cons similar web based methods general based findings directions future web based interventions menopause provided elsevier ireland ltd rights reserved
systematic method designing log domain wave filters presented wave filters simulate topologically functionally passive double terminated ladder prototype filters low sensitivity design log domain based transposition signal flow graph sfg corresponds wave equivalent elementary two port blocks linear domain corresponding log domain sfg achieved using appropriate set complementary operators order preserve linear operation whole circuit simulation results fifth order low pass fourth order bandpass log domain wave filter given using hspice proposed circuits suitable low voltage operation high frequency applications
paper makes case competitive third party regulatory arrangements draw attention service provision aspect regulatory administration using multiple methods study examines service diversification service quality differences exhibited third party administrators organic food regulations examining service emphases third party regulatory administrators differ organizational form study documents inclusion nonprofit private third party regulatory administrators may expand services offered performed alongside regulatory program functions implications findings regulatory administration field public management generally discussed
recent years voice internet protocol voip gained popularity application internet technology various applications including voip topic session initiation protocol sip attracted major concern researchers sip advanced signaling protocol operating internet telephony sip uses digest authentication protocols simple mail transport protocol smtp hyper text transport protocol http user seeks sip services authentication plays important role providing secure access server authorized access seekers insecure channel based protocol sip authentication protocol susceptible adversarial threats therefore security big concern sip authentication mechanisms paper reveals security vulnerabilities two recently proposed sip authentication schemes voip irshad scheme multimed tools appl doi arshad nikooghadam scheme multimed tools appl doi later scheme based former scheme irshad scheme suffers password guessing user impersonation server spoofing attacks arshad nikooghadam scheme threatened server spoofing stolen verifier attack none two schemes achieve mutual authentication also fails follow single round trip authentication design irshad scheme overcome weaknesses propose provable secure single round trip sip authentication scheme voip using smart card formally prove security scheme random oracle demonstrate discussion resistance various attacks comparative analysis shows proposed sip authentication scheme offers superior performance little extra computational cost
ethnopharmacological relevance corn silk stigma zea mays traditionally used weight loss stimulation treatment cystitis urinary infections obesity purple corn silk rich polyphenolic substances reported anti diabetic anti obesity effect animal studies however scientific evidence mechanisms targets action purple corn silk related adipocyte life cycle limited aim study determine phytochemical compositions investigate anti obesity potential purple corn silk focusing interruption adipocyte life cycle effect pre adipocyte proliferation adipogenesis adipocyte lipolysis apoptosis materials methods ethanolic purple corn silk extract pcs prepared investigated phytochemical compositions technique anti obesity potential using murine cell line using methyl thiazole tetrazolium mtt assay effects pre adipocytes adipocyte viability preadipocytes proliferation incubation period evaluated addition anti adipogenesis via inhibition adipocyte differentiation reduction total lipid accumulation evaluated using oil red staining spectrophotometric methods respectively lipolysis effect determined measurement glycerol released content using glycerol test kit treatment pcs adipocytes apoptosis inductive effect done using amidinophenyl indolecarbamidine dihydrochloride dapi staining method results polyphenols including anthocyanins quercetin phenolic acids derivatives found major chemical compositions pcs multiple stages interruption adipocyte life cycle anti obesity effect pcs interestingly demonstrated compared control pcs concentration range showed anti adipogenesis effect expressing significant inhibition preadipocyte proliferation incubation period significant decreasing total lipid accumulation concentration moreover pcs exhibited lipolysis apoptosis inductive effect dose dependent manner significance concentration increase released glycerol content control nuclei condensing apoptotic bodies relative apoptosis induction control conclusion data evidenced anti obesity potential pcs related interruption multiple stages adipocyte life cycle potency attributed inhibition adipocyte proliferation adipogenesis well induction lipolysis apoptosis high concentration however vivo investigation considered insist possibility applications pcs prevention treatment obesity
background vitamin possibly vitamin established association fracture risk vitamins however less studied aim determine whether specific micronutrients vitamin play role risk hip fracture bone turnover methods case control study blood drawn measurements vitamins folic acid well bone turnover markers osteocalcin bone specific alkaline phosphatase upon admission hip fracture patients home dwelling non fractured controls results vitamin populations reported previously results low vitamin concentrations independently associated risk hip fracture adjusted odds ratio confidence interval per smol increase vitamin concentration jtmol vitamin respectively results principally unchanged vitamin body mass index potential confounders adjusted vitamins except folic acid correlated positively total osteocalcin negatively bone specific alkaline phosphatase conclusions low vitamin concentrations associated increased risk hip fracture possibly mediated bone turnover mechanisms elsevier ltd european society clinical nutrition metabolism rights reserved
novel approach proposed study eliminate chaotic motion fuzzy controller appropriate dither first back propagation neural network model used approximate multiple time delay chaotic system linear differential inclusion ldi state space representation established dynamics model based ldi state space representation study proposes delay dependent stability criterion derived terms lyapunov direct method guarantee trajectories multiple time delay chaotic mtdc system fuzzy control steered periodic orbit subsequently stability condition criterion reformulated linear matrix inequality lmi according lmi fuzzy controller synthesized tame multiple time delay chaotic mtdc system fuzzy controller suppress chaos high frequency signal commonly called dither simultaneously injected eliminate chaotic motion regulating dither parameters frequency dither high enough trajectories dithered chaotic system corresponding mathematical model relaxed system made close desired make possible obtain rigorous prediction dithered chaotic system behavior establishing relaxed system finally study provides numerical example chen chaotic system simulations illustrate concepts discussed throughout paper published elsevier
introduction young adults autism spectrum disorders often face substantial difficulty finding retaining paid employment study aimed evaluating usability ready set work video modeling application use adolescents without autism spectrum disorders participation vocational world test whether discriminate two groups terms response simulated social dilemmas within vocational contexts method twenty adolescents autism spectrum disorders typically developing adolescents aged years trained use application followed completion two usability tools intrinsic motivation scale relevance questionnaire result groups found application useful relevant job readiness tool autism spectrum disorders group significantly greater difficulty identifying adaptive maladaptive responses found application relevant compared control group conclusion ready set work appears good usability social validity suggesting potential computerized video modeling tool provide support acquisition improvement social vocational skills adolescents general specifically autism spectrum disorders
four way proportional directional control valve widely used main stage spring constant two stage proportional control valve pdv since tradeoff made manufacturing costs static performance two symmetry dead zones introduced main stage spring constant center dead zone caused center floating position intermediate dead zone caused intermediate position though intermediate dead zone much smaller center dead zone significant effect dynamic position tracking performance paper cascade dead zones problem typical two stage pdv analyzed cascade dead zones model proposed main stage spring constant cascade dead zones inverse method improved gain estimation dead zone detection compensate dead zone nonlinearity finally digital controller designed verification comparative experimental results indicate effective reduce large position tracking error proposed method applied isa published elsevier ltd rights reserved
paper presents compact reliable low power rail rail class operational amplifier opamp suitable integrated battery powered systems require rail rail input output swing high slew rate maintaining low power consumption opamp fabricated standard cmos technology exhibits open loop gain cmrr experimental measurements prove correct functionality operating single supply performing competitive characteristics compared similar amplifiers reported literature rail rail input output operation mhz unity gain frequency slew rate capacitive load power consumption elsevier ltd rights reserved
interleukin important cytokine pathogenesis psoriatic arthritis secukinumab recombinant high affinity fully human immunoglobulin kappa monoclonal antibody selective binding neutralization interleukin providing alternative mechanism action current treatments secukinumab shown efficacy key clinical domains psoriatic arthritis present paper discuss role interleukin clinically relevant target treatment psoriatic arthritis based preclinical findings dose ranging regimen finding randomized placebo controlled clinical trials
objective daylight important zeitgeber entraining circadian rhythm clock cycle especially within polar circle long polar nights several months year phase delays sleep timing may occur mean shift normally small however individual variation phase shifts large implicating moderating factors examined role several self regulatory variables mood fatigue behavioral habits psychological self regulation moderators seasonality sleep timing chronotype methods sample young adults females mean age females years males years participated prospective study across three seasons september december march tromso norway degrees sleep diary sleep health related questionnaire data collected time point results sleep timing chronotype delayed dark period december compared brighter photoperiods september march comparable effects observed insomnia fatigue mood depression anxiety subjective health complaints physical activity school related stress importantly depression fatigue moderated degree seasonal shifting sleep timing whereas self regulation indicators eating habits physical activity psychological self regulation conclusion seasonality sleep timing chronotype confirmed seems depressive symptoms dark period exacerbate phase shifting problems people living sub arctic regions elsevier rights reserved
background understanding social inclusion among risk populations deepen understanding specific needs aim study explored level social inclusion among people psychotic related conditions using standardised interview method social inclusion interview schedule used two research projects people psychosis participated studies recruited part irish programme research psychotic conditions descriptive statistics used quantify participants level social exclusion results data participants available one cohort smaller cohort shorter mean duration illness participants mean age majority lived community satisfied living arrangements cohort two areas community integration emerged problematic something productive close someone community higher level perceived stigma among cohort longer duration illness discussion conclusion evidence social inclusion found among participants areas concern particularly regard integration work social connectedness
paper describes novel electric vehicle charging management system designed control load considering simultaneously owners requirements electrical network technical limitations system developed integrated existing commercial equipment smart grids distribution transformer controllers scada systems electrical vehicles charging stations performance smart charging system evaluated using typical portuguese low voltage network test case several assumed exist results obtained prove effectiveness system allowed charging according owners preferences without increasing network peak load creating voltages overload problems
optimal project scheduling nonconvex time cost relations represents challenging problem construction management nonconvex time cost relations may appear construction project several different duration options available activities due alternative technological processes enabled realization wide accessibility production resources source nonconvexity project scheduling optimization problem also project penalty bonus duration relations arranged within construction contract aim paper present mixed integer nonlinear programming minlp based optimal time scheduling construction projects nonconvex costs purpose minlp model developed applied numerical example literature example construction project time cost trade analysis practical nonconvex penalty function given paper demonstrate advantages minlp optimization example literature first presented capability minlp approach obtain optimal solution difficult highly combinatorial nonconvex discrete project scheduling problem thereupon following example revealed optimal project time cost curve may take nonuniform shape account discrete nature activity direct cost options nonconvex relation project duration total cost way presented study intends provide practitioners new information field optimization techniques project scheduling well alternative view performance total cost project duration changed
introduction modern techniques computer aided design tridimensional prototyping manufacturing silicone elastomer custom implants growing widely modified surgical indications unit materials methods presenting experience cases managed authors describe method conception scans virtual image body manufacture custom made implant perfectly adapted anatomy one operative techniques described three main indications funnel chest pectus excavatum cases according modified chin classification corrected simply satisfactorily approach may render thoracic surgery techniques obsolete indeed operations remain risky doubtful functional utility poland syndrome cases use custom made implant compensation muscle volume frequently used improved transfer adipose tissue classic breast implant leg atrophies cases receive custom elastomer implants introduced sub fascial plane results results excellent pectus excavatum difficult optimize two indications requiring sometimes complementary techniques complications rare often benign implants endure life quality life psychological comfort self esteem improved low morbidity without undergone painful surgical experience conclusion reconstructive procedures congenital malformations custom made silicone implants open new field activity surgical specialty vast opportunities elsevier masson sas rights reserved
multiple sclerosis known partially heritable autoimmune disease risk developing increases typically normal population identical twins one twin affected much heritability explained due almost entirely genes affecting immune response largest first identified genetic risk factor allele mhc class hla drb gene hladrb increases risk threefold hla drb gene expressed antigen presenting cells protein functions presenting particular types antigen cells discovery supported development first successful immunomodulatory therapies glatiramer acetate mimics antigen presentation process interferon beta targets cell activation genetic risk variants single nucleotide polymorphisms snps described snps located within close genes expressed predominantly acquired innate immune cell subsets indicating contribute pathogenesis risk alleles indicate variation regulation gene expression rather protein variation underpins genetic susceptibility review discuss expression function risk genes well effect risk snps indicate specific acquired immune cell processes target current successful therapies also point novel therapeutic approaches
background study sought investigate external photon beam radiation catheter free ablation atrioventricular junction intact pigs methods results ten pigs randomized either sham irradiation irradiation atrioventricular junction animals underwent baseline electrophysiological evaluation cardiac gated multi row computed tomographic imaging beam delivery planning intensity modulated radiation therapy doses coronary arteries optimized invasive follow conducted months irradiation mean volume irradiated target dose mean follow length irradiation days irradiated animals complete atrioventricular block achieved animals dose groups using targeting margins ablation lesion size notably increased delivered dose volumetric effects isodose lines around target volume mean macroscopically calculated atrial lesion volume dose groups lesions extended anteriorly interventricular septum short term side effects observed damage observed tissues esophagus phrenic nerves trachea however histology revealed field beam effects outside target volume conclusions single fraction doses low caused lesion interruption cardiac impulse propagation using respective target volume doses maximal point doses coronary arteries could kept target conformity lesions fully achieved using approach
background rescue maritime disaster remains great challenge emergency medicine objective performed overview rescue efforts among victims sunken cruise ship eastern star changjiang river marine disaster well possible preventive measures maritime transport situations methods rescue records victims sunken ship analyzed retrospectively demographic data rescue effects accident inducement injury disposition reviewed thorough analysis point view maritime traffic safety also performed results victims killed survived survivors classified based gender rescue type rescue spot follows male female tourists ship staff breakdown rescue spot jianli hubei province china survivors saved initial disaster survivors suffering somato psychotrauma urgently treated limb injuries infections upper respiratory tract lungs fluid electrolyte imbalance acute traumatic stress incident severe maritime disaster since establishment people republic china october due large number elderly victims fast overturning speed severe weather conclusions emergency rescue requires automated intelligent systems maritime safety increased focus must placed public welfare ethics goal influencing prosocial behavior rather pursuit profit elsevier inc rights reserved
background dutch healthcare inspectorate supervises care providers order improve quality care recently inspectorate assessed promoted use guideline smoking cessation counselling midwifery practices supervision programme consisted announcement enforcement deadline guideline site visits purpose qualitative study identify factors related guideline adherence supervision programme investigate whether programme helped improve adherence methods conducted semi structured interviews inspected non inspected midwives additionally studied documents observed inspection process sampled midwives work primary care midwifery practices providing care pregnant smokers questions included current provision smoking cessation counselling support midwife counselling recent changes provision counselling reasons recent changes knowledge supervision programme experiences supervision inspectorate results results show guideline adherence depends several factors awareness familiarity guideline important outcome expectancy additionally motivation guideline factors environment factors mentioned besides previously documented factors found professional collaboration also determined guideline adherence increased collaboration counselling associated greater adherence guideline provision counselling taking required training supervision programme helped improve stop smoking counselling making midwives aware counselling giving extrinsic motivation provide counselling conclusion motivation environmental aspects important factors related guideline adherence professional environment added significant factor improved guideline adherence partly attributable supervision programme
paper presents straightforward current mode cmos squarer circuit proposed circuit exploits square law characteristic mos transistor saturation region squarer circuit used implement multiplier exponential functions demonstrate method circuits designed cmos process using single supply hspice simulations level model parameters confirm operation proposed cmos circuits copyright john wiley sons ltd
arinc provides strong isolation mechanism safety computing fields aircrafts sel generation microkernel formally verified functional correctness provides desirable code base partitioning operating systems long way sel partitioning take first step focus temporal aspect implementing partitioned scheduler based sel however sel implements stiff scheduler inside kernel conflicts genera principles arinc standard temporal partitioning address problem propose user mode approach also elaborate performance scheduler
background pain management clinics major sources prescription opioids texas government passed several laws regulating pain clinics reduce opioid related toxicity understanding impact laws inform policy geared toward making laws effective curbing growing epidemic opioid overdose especially among elderly population objectives examine longitudinal association laws regulating pain clinics opioid prescribing opioid related toxicity among texas medicare recipients methods claims data texas medicare part recipients used assess temporal trends percentage patients filling schedule schedule iii opioid prescription hospitalization opioid toxicity relationships texas laws regulating pain clinics excluded cancer diagnosis join point trend analysis bayesian information criterion selection methods used evaluate change monthly percentages patients filling opioid prescriptions hospitalization time results short lived decline monthly percentages patients filled schedule schedule iii opioid prescription laws regulating pain clinics decline lasted months subsequent new laws effect percentages patients filled opioid prescription hospitalized potential opioid toxicity hospitalizations opioid toxicity highest winter lowest summer conclusions changes percentages opioid prescribing opioid related hospitalizations time associated laws regulating pain clinics
urgent effectively mitigate flood disasters humid mountainous areas southeastern china increasing flood risk urbanization industrialization study rural district area planning build industrial park covering area changting selected estimate potential collectable rainwater extent runoff volume potentially mitigated rainwater harvesting addition optimum cistern capacity rainwater harvesting system planned industrial park evaluated using daily water balance simulation cost efficiency analysis results showed rainwater harvesting planned industrial park great potential annually collectable rainwater approximately optimum cistern capacity determined optimum cistern capacity annual rainwater usage rate showing neither financial savings deficits rainwater harvesting reduce runoff volume cases critical rainfall storm annual average maximum daily rainfall runoff volume case maximum daily rainfall respectively surface runoff collected stored cisterns rainfall amount less rainstorm event
variety new social media applications developed ever increasing rate number related potential vulnerabilities related attack vectors also increasing traditionally social engineering attacks always major cause concern information security departments however theft abuse manipulation personal information malicious purposes become even prolific since mass adoption social media gaming applications average person largely fueled boom social media gaming applications newly introduced ever evolving apps continue introduce new vulnerabilities due poor system design coding practices led multitude sophisticated attacks digital crimes attacks malware infections ransomware session hijacking sql injection man middle attacks facilitated part race developing social media platforms applications hence effective countermeasures prevention techniques introduced detect minimize resulting damage losses associated trend paper presents novel credentials crawling proof concept exploit illustrate ease attacks launched proof concept implemented via stealthy application implemented part using commercial shelf application camera mouse newly developed stealth robot uses stealth techniques conceal intended target victim proposed approach enables developed robot application remain undetected leading commercial anti virus solutions developed robot tested different environments various operating systems protected various commercial antivirus solutions presented approach tested computers belonging people different walks life including graduate undergraduate students faculty staff consent initial test result demonstrates proposed technique effective tool assist promoting awareness variety user focused cyber attacks especially phishing attacks
paper propose novel adaptive kernel radial basis function neural networks proposed kernel adaptively fuses euclidean cosine distance measures exploit reciprocating properties two proposed framework dynamically adapts weights participating kernels using gradient descent method thereby alleviating need predetermined weights proposed method shown outperform manual fusion kernels three major problems estimation namely nonlinear system identification patter classification function approximation
cmos based application specific integrated circuit asic designs total power consumption dominated dynamic power dynamic power consists two major components namely switching power internal power paper present low power design digit serial finite field multiplier proposed design factoring technique used minimize switching power best knowledge factoring method reported literature used design finite field multiplier architectural level logic gate substitution also utilized reduce internal power proposed design along several existing similar works realized asic platform comparison made synthesis results show proposed multiplier design consumes least lower total power previous work comparison
mineral forms iron oxide hematite goethite jarosite important widely distributed earth surface used indicators mineral exploration iron oxide abundance rocks containing minerals estimated absorption depth wavelengths around reflectance spectrum depth also affected extraneous factors grain size topography paper investigated effect grain size reflectance spectra proposed method estimating iron oxide abundance surface rocks using remotely sensed data suppression effects grain size topography reflectance spectra measured laboratory rock powder samples different grain sizes containing iron oxide minerals reflectance increased decreasing grain size presence ferric iron caused absorption depth almost constant around irrespective chemical composition sample addition difference reflectance slope function grain size iron oxide abundance estimated accurately mcr maximum absorption depth absorption center effect grain size topography suppressed slope continuum removal method takes ratio original spectrum continuum respectively correlation mcr results datasets actual spectral chemical iron oxide laboratory measurements revealed mineral forms also need considered mcr results significantly correlated rock samples classified containing different forms iron oxide minerals hematite goethite jarosite finally mcr applied aviris dataset cuprite site nevada usa results represented enrichment zones iron oxide within hydrothermally altered areas elsevier rights reserved
focus article theoretical understanding behind clinical application newly developed music therapy assessment tool assessment parenting competencies apc psychometric properties analyzed successfully prior publications advantages challenges nonverbal emotional interactional medium music assessing parent child interaction parental capacity presented discussed assessment model relates theories attunement autonomy attachment clinical relevance practice within field child protection addressed according clinical application tool scores apc interpreted clinically relevant combination playful rigorous approach apc provide useful information families family therapists social service professions within field child protection including level mutual attunement nonverbal communication skills emotional parental response possibly indications attachment behavior child apc thereby help indicate severity situation possible therapeutic direction family question
paper node adaptive rearrangement presented based estimated error various domains problems fracture mechanics discrete least squares meshless method dlsm method one approximate methods recently introduced used various fields method based minimization least squares functional respect nodal parameters uses moving least squares method calculating shape functions due natural process problem solving calculating shape functions residuals calculated values considered objective function rearrangement nodes three popular methods constructing shape functions discontinuous domains transparency method utilized similar numerical methods different procedures refinement improvement results however adaptive rearrangement employed without increasing computational cost paper charged system search css algorithm used tool adaptive rearrangement repositioning process efficiency effectiveness proposed adaptive rearrangement technique tested benchmark two dimensional crack examples available analytical solution around crack tips sharif university technology rights reserved
presently medications approved children hereditary angioedema hae extremely limited especially case children years age reason reviewed summarized data treatment children hae available data indicate plasma derived inhibitor safe effective treatment option hae pediatric patients including years age therapies also appear safe year age less data available importantly home based treatment hae age group appears safe effective improve quality life findings support current hae consensus guidelines strongly recommend use plasma derived inhibitor first line treatment children encourage home self treatment
pediatric functional abdominal pain disorders fapds associated increased health care utilization school absences poor quality life qol cost effective accessible interventions needed multisite study tested effects session cognitive behavioral intervention delivered parents person remotely primary outcome pain severity secondary outcomes process measures parental solicitousness pain beliefs catastrophizing child reported coping additional outcomes hypothesized priori assessed included functional disability qol pain behavior school absences health care utilization gastrointestinal symptoms study prospective longitudinal baseline months follow randomized conditions social learning cognitive behavioral therapy person slcbt phone slcbt education support condition phone participants children aged years fapd parents dyads although significant treatment effect pain severity found slcbt groups showed significantly greater improvements compared controls process measures parental solicitousness pain beliefs catastrophizing additional outcomes parent reported functional disability pain behaviors child health care visits abdominal pain remote condition qol missed school days effects found parent child reported gastrointestinal symptoms child reported qol coping findings suggest children fapd brief phone slcbt parents similarly effective person slcbt changing parent responses improving outcomes reported pain symptom report compared control condition
nonideal effects comparator dead time synchronous controlled converter adversely affect stability four switch noninverting buck boost nibb converter pulse skipping phenomenon occurs mode transition region near boundary step step regions phenomenon leads unstable output voltage unpredictable output voltage ripple however two results may damage entire power system application system brief proposes enhanced duty cycle overlap control technique digitally controlled nibb converter proposed technique offers two duty cycle limitations various conditions mode transition region ensures stability digital controller output voltage moreover technique involves combining duty cycles step step upmodes deriving accurate value output voltage experimental results derived digital controller implemented field programmable gate array based platform revealed output voltage nibb converter stable throughout transition region observed input voltage converter provided ion battery output voltage typically suitable communication systems audio systems pad power supplies switching frequency mhz maximum load current
phase field method uses non conserved order parameter define phase state system versatile method moving boundary problems method choice simulating microstructure evolution domain materials engineering solution phase field evolution equations avoids explicit tracking interfaces often implemented structured grid capture microstructure evolution simple elegant manner restrictions grid size accurately capture interface curvature effects lead large number grid points computational domain render simulation computationally intensive realistic simulations however availability powerful heterogeneous computing platforms super clusters provides advantage perform large scale phase field simulations efficiently paper discusses portable implementation extend simulations across multiple cpus using mpi include use gpus using opencl solution scheme adapts isotropic stencil avoids grid induced anisotropy use separate opencl kernels problem specific portions code ensure approach extended different problems performance analysis parallel strategies used study illustrate massively parallel computing possibility phase field simulations across heterogeneous platforms elsevier rights reserved
role microglia healthy brains beginning receive notice recent studies revealed phagocytic cells control patterning wiring developing central nervous system cns regulating amongst many processes programmed cell death activity dependent synaptic pruning synapse maturation microglia also play important roles mature brain demonstrated effects behavior converging evidence human mouse studies together raise questions role microglia disorders brain development autism schizophrenia review summarize number major findings regarding role microglia brain development highlight key questions avenues future study article part special issue entitled neuroimmunology health disease elsevier rights reserved
labeling children social play behavior important process children peer play analysis traditionally done experienced coders growing volume data automatic methods labeling increasingly required paper presents novel method classify children social play behavior peer play scenarios three categories solitary play parallel play group play based two key cues attentiveness proximity proposed play observation scale unary features pairwise features calculated describe relationships child whole context interactions two children inspired recent studies social behavior analysis interaction recognition children activities classified support vector machine svm hidden conditional random field hcrf method evaluated dataset children peer play scenarios collected psychology researchers results show method good performance dataset
paper proposes light weight online classification method detect smarthpone user postural actions sitting standing walking running actions named user states since inferred analysis data acquired smartphones equipped accelerometer sensors differentiate one user state another many studies found literature however study differs others offering computational lightweight online classification method without knowing priori information moreover proposed method provides standalone solution differentiation user states also assists widely used offline supervised classification methods automatically generating training data classes input system matrices furthermore improve existing methods purpose online processing reducing required computational burden extensive experimental results show proposed method makes solid differentiation user states even sensor operated slower sampling frequencies
paper studies software implementation ultrasonic imaging system total focusing method order accomplish real time requirements parallel programming techniques used using gpgpu techniques two different implementation alternatives analysed showing proper planning access data improves performance algorithm
introductionthe insite trial prospective multicenter study sacral neuromodulation snm therapy interstim system subjects overactive bladder oab one primary aims study report long term safety tined lead analysis provides detailed descriptions device related adverse events aes surgical interventions months methodsanalysis included subjects completed test stimulation tined lead received full implant reported device related aes months clinical events committee cec adjudicated aes months resultsdevice related aes occurred subjects one considered serious fifty six percent device related aes occurred implant months frequent device related aes undesirable change stimulation implant site pain implant site infection events implant site pain required surgical intervention two resulting explant ten subjects experienced events surgical site infection including additional cellulitis five resolved antibiotics eight required explantation overall surgical intervention rate common reasons pain surgical site lack loss efficacy infection conclusionsalthough rate reported aes minor resolved without surgical intervention surgical intervention required subjects majority revision replacement neurourol urodynam wiley periodicals inc
contribution analyses knowledge aberrations affecting non verbal communication children autistic spectrum disorder asd perspective speech language therapists slts working schools well medical settings czech republic via questionnaire responding slts originally addressed slts perceive specifics regarding disruption nonverbal communication frequent deficits detected relating pragmatics lexical semantic linguistic level morphological syntactic linguistic level research highlighted visible deficits associated mainly knowledge domain slts within asd authors published elsevier ltd
background antidotes appropriate non vitamin antagonist vka oral anticoagulants noacs yet widespread clinical use efficacy prothrombin complex concentrate pcc noac associated bleeding remains unclarified methods ten noac users women median years old developed major bleeding received pcc prospectively enrolled eight single center noac users women median years old intracerebral hemorrhage period receive pcc studied comparison results pcc treated patients developed intracerebral hemorrhage developed subdural hematoma another developed gastrointestinal bleeding median size intracerebral hemorrhage relatively lower reported size patients without noacs patients received median pcc pcc administration median inr changed median aptt changed five patients developed intracranial hematoma expansion required surgical hematoma evacuation symptomatic thrombotic events occurred either group participants died participants group independent conclusions ten noac users developed major bleeding given relatively low doses pcc effect pcc early cessation bleeding unclear therapy trigger thromboembolic complications elsevier rights reserved
multiprotein bridging factor mbf transcriptional activator mediates transcriptional activation bridging sequence specific activator like proteins tata box binding protein tbp mbf well studied arabidopsis thaliana saccharomyces cerevisiae drosophila melanogaster homo sapiens well understood filamentous fungi study report identification characterization mbf ortholog mombf rice blast fungus magnaporthe oryzae causes devastating rice blast disease ideal model studying growth development pathogenic mechanisms filamentous fungi mombf encodes amino acid protein typical mbf domain hth domain bioinformatics used analyze structural domains mombf phylogenetic relationship homologs different organisms generated mombf deletion mutants delta mombf functional complementation transformants found deletion mutants showed significant defects vegetative growth tolerance exogenous stresses sorbitol nacl moreover delta mombf showed reduced pathogenicity smaller infection lesions wild type complementation strain decreased response accumulation ros reactive oxygen species planta initial infection stage taken together data indicate mombf required vegetative growth pathogenicity stress response oryzae
prime objective current investigation develop topical skin care cream loaded artemis comosta extract versus placebo control evaluated non invasively changes skin barrier function epidermal hydration levels transepidennal water loss tewl healthy human volunteers active cream carrying extract alamos consosits internal phase emulsion prepared placebo contained extract stability assessment creams performed various storage conditions relative humidity degrees effects epidermal hydration tewl observed applying active cream one side placebo side face healthy human volunteers weeks period using comeometer mpa tewameter mpa results indicated creams active placebo remained stable storage conditions samples manifested non newtonian shear thinning behavior increasing shear rate whereas statistical interpretation indicated effects active cream superior placebo significantly improves epidermal hydration levels reduces tewl end study period compared baseline value surface evaluation living skin sels parameters ser sesc sestn sew also assessed indicated significant reduction conclusively creams loaded inane comostis extract exhibit better physicochemical stability represent propitious improvement skin barrier function used functional moisturizing anti aging ingredient topical skincare products
design machine elements course one difficult complicated courses mechanical engineering program requires inventive concept generation knowledge geometrical design basic knowledge stress deformation analyses three elements machine elements design philosophy established developed course material chosen carefully since time constrains allow cover design essential machine elements material covered lectures textbook readings homework problems design projects addition textbook content course contains five special elements idea generation safety considerations design day dod designer liability study three projects including final project shaft design idea generation project students generate idea machine mechanical device safety consideration project done inspection documentation unsafe elements campus shaft design project students design shaft system given constrains dod students present existing advanced machines chosen using different sources industrial internship experience liability assignment addresses designer legal responsibility case defective product caused injury accident material taught course larger conventional machine element design course elements added beyond structural analysis bring better understanding engineering problems senior design course later engineering practice allow students connect theory real world engineering challenges gives students satisfaction learning process cognitive benefits engineering practice unconventional inventive design approach teaching team course instructor gta problem solving based many years instructor experience teaching engineering problem solving design learning pattern students work teams problem solving design exercises also helps conduct course thanks elements learning experience course unique engaging despite high level difficulty associated
understanding genetic basis philadelphia negative myeloproliferative neoplasm mpn got much progress recent years effect calr jakvf mutations clinical progression prognosis primary fibrosis pmf remains relatively obscure meta analysis searched pubmed embase web science databases observational studies published february researches evaluated calr jakvf mutations pmf relevant complications splenomegaly leukemic transformation thrombosis overall survival selected pooled adjust odds ratio hazard risk corresponding confidence intervals calculated calr mutant versus jak mutant categories twelve studies involving calr mutated jakvf pmf patients analyzed calr mutated patients displayed lower risk splenomegaly thrombosis showed significant difference risk leukemic transformation compared jak mutated patients calr mutation favorably affected overall survival jak mutation led poorer survival rate meta analysis confirmed genetic classification pmf calr jak mutations carried significant prognostic relevance
preservation kidney function kidney donation depends kidney reserve potential remaining kidney boost function loss kidney traditional chinese medicine size shape external ears examined evaluate person kidney health hypothesized ear size might practical yet overlooked marker kidney reserve fifty kidney transplantation donors participated study length width ears participants measured one post donation visits pre donation serum creatinine post donation serum creatinine well relevant parameters age sex weight height etc participants extracted medical records estimated gfr calculated serum creatinine age sex using ckd epi equation ear length negatively associated gfr decline kidney donation every cmincrease ear length associated less gfr decline kidney donation confidence interval earwidth aswell age sex bodyweight height body mass index pre donation egfr significantly associate gfr decline findings support notion traditional chinese medicine ear morphology may associated kidney health suggest ear lengthmight useful predictor kidney function decline kidney donation
background aims proportion hcv infected patients age years western countries increasing growth advent new antiviral therapy bring question real world efficacy safety combination sofosbuvir sof simeprevir smv plus flat dose ribavirin rbv elderly patients cirrhosis compared younger patients methods retrospective observational multicentre real life investigation study sof smv rbv duration weeks hcv genotype infected patients cirrhosis results patients enrolled study compensated cirrhosis years age sustained virological response weeks svr achieved aged years diabetes common comorbidity patients years compared younger patients common adverse event elderly patients grade anaemia conclusions sofosbuvir simeprevir plus daily flat dose rbv weeks highly effective safe genotype elderly patients compensated cirrhosis
computing discrete geodesic distance triangle meshes one fundamental problems computational geometry computer graphics problem effective window pruning strategy significantly affect actual running time due importance conduct depth study window pruning operations paper produce exhaustive list scenarios one window make another window partially completely redundant identify maximal number redundant windows using pairwise cross checking propose set procedures synchronize local window propagation within triangle simultaneously propagating collection windows one triangle edge two opposite edges basis synchronized window propagation design new geodesic computation algorithm based triangle oriented region growing scheme geodesic algorithm remove redundant windows earliest possible stage thus significantly reducing computational cost memory usage later stages addition adopting triangles instead windows primitive propagation management algorithm significantly cuts data management overhead result runs times faster mmp ich algorithms times faster fwp mmp fwp algorithms also incurs least memory usage
laboratory experiments conducted order investigate effectiveness new scour countermeasure consisting horizontal extension plate downstream gated spillway stilling basin structure experiments performed scale model one south florida water management district sfwmd gated spillway structures gated spillway experienced worrisome downstream scour currently riprap scour countermeasure documented structures eps various lengths installed downstream stilling basin equilibrium scour measured found plate length approximately times exiting flow depth shortest length resulted significant scour reduction downstream scour translation measured flow patterns reveal altered flow patterns transferring plunging flow downstream eliminating near bed reattachment surface recirculation possibly due decreased interaction plunging flow stilling basin face
paper presents variable structure sliding mode control smc scheme direct torque control dtc wind farm based permanent magnet synchronous generator pmsg consists pmsgs connected common bus system rectifier bus connected electrical network using one inverter system grid side filter well transformer efficiency greatly improved using appropriate control approach control strategy uses technique dtc regulate speeds pmsgs maximum power point tracking mppt mode besides employing smc grid side inverter controlled inject generated power electrical network regulate link voltage achieve unity power factor used control strategies provide optimal control solution systems based pmsg
comprehensive treatment system consisting geotextile bag zeolite bed constructed wetland devised remove solids nutrients swine house waste alkalinity observed reduced geotextile bag wetlands one day waste flush cycle cod reduced geotextile bag reduced zeolite treatment followed constructed wetland wastewater passed geotextile bag reduction cod occurred flush cycle reduction observed zeolite reductions total total observed wastewater passed geotextile bag zeolite wetland treatment systems flush cycle approximately adsorbed zeolite bed presumed lost volatilization process zeolite treatment elsevier rights reserved
aim study analyse development different dimensions emotional intelligence adolescents one school year cross sectional study involving adolescents sexes six school years year spanish secondary school age year spanish baccalaureate age participants administered spanish version emotional quotient inventory young version short caraballo villegas consistently previous research findings indicate except stress management dimension female sample group none dimensions emotional intelligence undergo substantial changes relation age
purpose study understand young appalachian mothers retrospectively construct sexual reproductive health communication events sixteen depth qualitative interviews conducted mothers ages south central appalachian region usa findings indicate within population peer influence stereotypes medical encounters formal health education experienced within culture exhibits tension normalising disparaging adolescent sexuality theoretical applied implications acknowledge role appalachian cultural values including egalitarianism traditional gender roles fatalism understanding social construction young people sexuality region practical implications sexual education nature communication healthcare setting applied current education curricula medical communication practices suggest future programmes may effective adapted specific culture within taught
getting higher occurrence cybercrimes means hacking identity theft network security violations necessitates robust system resolving issues new era using conventional user authentication methods like providing login ids passwords pin two factor authentication methods fading offer required level security required since biometrics come forward efficient alternative technique provide security keystroke typing dynamics uses behavioral characteristics like typing rhythms person authentication protection method effortlessly integrates existing environment could scaled across web also technology getting promoted upcoming years non invasiveness unobtrusiveness low deployment cost thereby security physical logical access improved proposed technique acts supplementary security layer besides traditional user ids passwords pin organizations making supplementary investments keystroke typing dynamics ensure robust user authentication system
sharing reusing big data relational databases semantic way become big challenge paper propose new approach enable semantic web applications access relational databases rdbs contents semantic methods domain ontologies used formulate rdb schema data order simplify mapping underlying data sources method consists two main phases building ontology rdb schema generation ontology instances rdb data automatically first phase studied different cases rdb schema mapped ontology represented rdf owl second phase mapping rules used transform rdb data ontological instances represented rdf triples approach demonstrated examples validated ontology validator
elbow joint pathologies highly prevalent persian speaking countries reliable low cost method like appropriate questionnaire mandatory early diagnosis elbow joint disorders among designed questionnaires patient rated elbow evaluation pree accepted commonly used scale evaluating pain dysfunction patients aims study cross culturally adapt also identify psychometric properties persian pree original version pree translated cross culturally adapted persian according guidelines beaton seventy three patients thirty nine healthy people enrolled study test retest reliability internal consistency evaluated using icc cronbach alpha item total correlation respectively construct validity investigated using disability arm shoulder hand dash questionnaire physical component scale pcs determine cutoff point discriminating patients non patients receiver operating characteristic curve plotted persian pree displayed high internal consistency cronbach alpha acceptable icc values subscales total score icc positive moderate correlation dash negative moderate correlation pcs observed cutoff point equal determined persian pree persian pree exhibited promising validity reliability findings supported applicability clinical situations consistent original version
sorting one important algorithms computer programming ordinary sorting algorithms analyzed compare algorithmic time complexity stability executive efficiency sorting algorithms verified java program costing time stability sorting algorithms compared provide certain reference sorting algorithm
distributed denial service ddos attacks become weapon choice hackers cyber extortionists cyber terrorists attacks swiftly incapacitate victim causing huge revenue losses despite large number traditional mitigation solutions exists today ddos attacks continue grow frequency volume severity calls new network paradigm address requirements today challenging security threats software defined networking sdn emerging network paradigm gained significant traction many researchers address requirement today data centers inspired capabilities sdn present comprehensive survey existing sdn based ddos attack detection mitigation solutions classify solutions based ddos attack detection techniques identify requirements effective solution based findings propose novel framework detection mitigation ddos attacks large scale network comprises smart city built sdn infrastructure proposed framework capable meeting application specific ddos attack detection mitigation requirements primary contribution paper twofold first provide depth survey discussion sdn based ddos attack detection mitigation mechanisms classify respect detection techniques second leveraging characteristics sdn network security propose present sdn based proactive ddos defense framework prodefense show framework utilized secure applications built smart cities moreover paper highlights open research challenges future research directions recommendations related sdn based ddos detection mitigation
proteins harbor domains short linear motifs facilitate functions interactions finding functional motifs protein sequences could predict putative cellular roles characteristics hypothetical proteins study present shetti motif interactive tool map uniprot prosite flat files search multiple pre defined consensus patterns experimentally validated functional motifs large datasets protein sequences proteome wide iii search motifs containing repeated residues low complexity regions leu pest rich motifs etc proof principle using comparative proteomics pipeline eleven proteomes encoded member poxviridae family searched experimentally validated functional motifs closely related viruses viruses infect host cells vaccinia variola viruses show similar motif containing proteins profile motifs encoded viruses correlated explains poxviruses able interact wide range host cells conclusion silico analysis useful establish dataset potential proteins investigation compare species
speech gestures autism spectrum disorder asd poorly understood historically gestures thought reduced social communicative disorder however reduced gestures consistently demonstrated empirical literature protodeclarative pointing reduced young children asd protoimperative pointing varied functions speech gesture may explain mixed findings verbally fluent adolescents asd controls completed narrative task standardized executive function task gestures narrative task serve wide range social cognitive functions reduced asd gestures executive function task serve primarily cognitive functions increased asd gesture function may best predictor presence absence gesture asd despite reduced social communicative gestures individuals asd may benefit gesture internal cognitive functions
thermoelectrics candidate niche electrical generator devices energy management present scientists focused thermoelectric material development module design procedure still relatively virgin state one well known methods reduced current approach rca module design current induced legs thermoelectric generator teg current density element manipulated changing area legs technique leads module architecture based efficient configuration legs current paper apply extended version technique show module higher volumetric power density designed compared original rca studies indicate combinations material properties optima yielding significant material savings without compromising power output determined current study directed towards obtaining high power output high temperature tegs rather focusing efficiency enhancement wiley vch verlag gmbh kgaa weinheim
monitoring analyzing floor vibrations determine human activity major applications fields health care security example structural vibrations could used determine elderly person living independently falls room occupied empty monitoring human activity using floor vibration promises advantages methods example privacy concerns methods vision based techniques compliance challenges wearable sensors analysis signals becomes classification problem determining type human activity unfortunately research groups performing research subject even though significant number techniques could applied field date systematic study challenges advantages using different types algorithms problem performed paper proposes benchmark problem encourage researchers design new algorithms monitoring human activity using floor vibrations provide dataset test new algorithms iii allow comparison proposed methods based set standard metrics benchmark consists seven different cases increasing difficulty case specific number sensors calibration signals type floor excitation forces considered paper also proposes specific metrics enable direct comparison different techniques research groups interested monitoring human activity using floor vibrations encouraged use experimental data evaluation metrics published paper develop methodologies enable community researchers easily compare contrasts techniques better understand type methods appropriate different applications elsevier ltd rights reserved
moderate correlations among gambling substance use crime suggest three behaviours may indicators single underlying problem trait poor impulse control tested whether self reported traits prospectively predicted future criminal recidivism accounting incarcerated adult offenders past criminal behaviour substance use gambling behaviour took multi construct approach measuring components impulse control utilizing three questionnaires assess sensation seeking poor premeditation reward sensitivity male participants incarcerated two federal institutions invited complete self report booklets participation self selected fully voluntary results indicated moderate correlations measures trait impulse control self reported drug use official criminal history gambling problems prospectively predicted post release criminal recidivism even accounting past criminal behaviour impulse control traits substance misuse although represent small percentage sample results suggest offenders high gambling problems represent particularly risk group future crime four times likely reoffend compared offenders without problem gambling results suggest may mutual impact problem behaviours life outcomes contribution poor impulse control
show continuously nonuniform coupled line section phaser limiting case step discontinuous coupled line multisection commensurate non commensurate phasers provides enhanced bandwidth diversity real time analog signal processing asp phenomenology component explained comparison step discontinuous using multiple reflection theory simple synthesis procedure provided bandwidth enhancement results suppression spurious group delay harmonics quasi harmonics diversity enhancement results greater level freedom provided continuous nature nonuniform profile phaser statements supported theoretical experimental results
comorbidity substance use disorders borderline personality disorder sud bpd psychiatric disorders little studied total drug dependent patients evaluated using semistructured interviews sud bpd patients multivariate analysis gender affective disorder anxiety disorder eating disorders cocaine benzodiazepine dependence early age onset drug consumption dependent paranoid antisocial personality disorders associated sud bpd several psychiatric comorbidities norm sud bpd patients therefore patients challenge clinicians
aims evaluate persistence rates patients receiving mirabegron therapy overactive bladder oab within institution month period identify determinants early discontinuation therapy assess overall patient satisfaction treatment methods hospital prescription data analyzed order identify patients prescribed mirabegron institution case notes retrospectively reviewed obtain demographic data previous treatments oab reasons discontinuation previous treatments duration treatment mirabegron overall satisfaction treatment assessed using oab satisfaction treatment questionnaire oab sat results one hundred ninety seven patients prescribed mirabegron previously discontinued anticholinergic therapy previously received intravesical botulinum toxin therapy prescribed mirabegron first line months persisted treatment fell months commonest reason discontinuation lack efficacy followed adverse effects overall patients preferred mirabegron previous treatments satisfied mirabegron therapy conclusion persistence rates mirabegron group patients oab satisfactory commonest reasons discontinuation unmet treatment expectations adverse effects treatment naive patients studies required assess mirabegron persistence rates longer term follow first line treatment different groups oab severity wiley periodicals inc
mucormycosis opportunistic fungal infection occurring immunocompromised patients serious life threatening condition even though diagnosed early mucormycosis mortality rate reaching report case mucormycosis diabetic patient hospitalized intensive care unit severe angiocholitis evolution lethal
aimthe aim present paper open discourse regarding unmet needs specific patients especially substance use disorder personality disorder multimorbidities overdiagnosis diagnosis overlap frequent additional aim review main therapeutic purpose concepts gestalt therapy might appropriate treatment patients often characterized difficulties aware contact methodsi first start overview gestalt therapy concepts illustrate gestalt awareness concepts applied sessions inpatient diagnosed substance use bipolar disorders addition patient face open criminal charge regarded antisocial personality disorder argued suffering post traumatic stress disorder resultsafter two month therapy period patient entered first time daily rehabilitation program community well prior hospitalizations awareness development different contact styles cycles experiences experienced process allowed patient start experiencing contact true needs environment contributed well improvement led supported rehabilitation reinsertion within society decrease relapses either drugs criminal activities copyright john wiley sons ltd
individuals autism spectrum disorder asd characterized severe deficits social communication whereby nature impairments emotional prosody processing yet specified investigated emotional prosody processing individuals asd controls novel lifelike behavioral neuroimaging paradigms compared controls individuals asd showed reduced emotional prosody recognition accuracy behavioral task neural level individuals asd displayed reduced activity sts insula amygdala complex basic emotions compared controls moreover coupling sts amygdala complex basic emotions reduced asd group finally groups differed respect relationship brain activity behavioral performance brain activity emotional prosody processing strongly related prosody recognition accuracy asd participants contrast coupling sts anterior cingulate cortex acc activity predicted behavioral task performance strongly control group results provide evidence aberrant emotional prosody processing individuals asd suggest differences relationship neural behavioral level individuals asd may account observed deficits social communication
background previous research produced inconsistent evidence association housing stability medication adherence among hiv positive individuals antiretroviral therapy objective conducted meta analysis housing adherence relationship based comprehensive search observational studies pubmed embase cochrane databases january january ten qualifying studies identified representing individuals methods random effects model used estimate overall effect size confidence interval robustness estimate determined sensitivity analysis heterogeneity assessed meta regression analysis subgroup analysis quality effects estimation publication bias evaluated funnel plot egger begg tests results summary effect association housing stability medication adherence positive significant standardized mean difference association slightly larger quality effects analysis standardized mean difference sensitivity analysis disclosed association robust level results subgroup meta regression analyses nonsignificant publication bias detected conclusion antiretroviral medication adherence increasing function housing stability magnitude effect small finding challenges view unstable housing incompat ible adherence questions potential benefit deferring antiretroviral therapy initiation patient housing circumstances improved
self report studies found evidence cultures differ display rules facial expressions appropriate different people different times however observational studies actual patterns facial behavior rare typically limited analysis dozens participants two three regions present first large scale evidence cultural differences observed facial behavior including participants countries around world used internet based framework collect video data participants two different settings homes market research facilities using computer vision algorithms designed dataset measured smiling brow furrowing expressions participants watched television ads results reveal novel findings provide empirical evidence support theories cultural gender differences display rules participants individualist cultures displayed brow furrowing overall whereas smiling depended culture setting specifically participants individualist countries expressive facility setting participants collectivist countries expressive home setting female participants displayed smiling less brow furrowing male participants overall latter difference pronounced individualist countries first study leverage advances computer science enable large scale observational research would possible using traditional methods
structural health monitoring one wishes use available measurements structure assess structural condition localize damage present quantify remaining life nonlinear system identification methods considered use parametric nonlinear physics based model system cast state space framework various nonlinear filters parameter learning algorithms used recover parameters quantify uncertainty paper focuses particle filter shows advantage assuming gaussianity posterior densities however known behave poorly high dimensional spaces especially static parameters added state vector improve efficiency concept rao blackwellisation applied use conditional linearities present equations marginalize states parameters infer conditional posterior pdf using kalman filtering equations method studied extensively particle filtering literature start discussion improving upon applying two well known algorithms benchmark structural system noticing structural systems high nonlinearities often localized remaining equations bilinear states parameters novel algorithm proposed combines marginalization approach second order extended kalman filter new approach enables marginalize states parameters contribute high nonlinearity equations thus improve identification unknown parameters copyright johnwiley sons ltd
rationale relationship development progression interstitial lung abnormalities ila clinical outcomes previously investigated objectives determine risk factors clinical consequences ila progression participants framingham heart study methods ila assessed participants serial chest computed tomography scans approximately years apart mixed effect regression cox models used assess association ila progression pulmonary function decline mortality measurements main results follow period participants ila either scan stable improving ila ila progression remaining participants without ila noted indeterminate least one scan increasing age increasing copies mucb promoter polymorphism associated ila progression adjustment covariates ila progression associated greater fvc decline compared participants without ila ila without progression median follow time approximately years adjustment ila progression associated increase risk death hazard ratio confidence interval compared without ila conclusions findings demonstrate ila progression framingham heart study associated increased rate pulmonary function decline increased risk death
body related checking behavior behavioral manifestation disturbed body image fosters development maintenance eating disorders body checking questionnaire bcq commonly used questionnaire measuring body related checking behavior internationally date validation studies available adult populations therefore aim study statistically test german language version bcq adolescents total female adolescents examined comprising anorexia nervosa bulimia nervosa healthy female adolescents confirmatory factor analysis supports subdivision bcq general factor subfactors overall appearance specific body parts idiosyncratic checking also found original version internal consistencies good alpha bcq able differentiate well adolescents without eating disorders significant correlations bcq body image questionnaires point good convergent validity german language bcq thus constitutes valid reliable instrument measuring body related checking behavior among adolescents clinical research practice
continuous monitoring actual evapotranspiration critical water resources management regional local scales although modis product moda provides viable sources monitoring day intervals spatial resolution coarse local scale applications study propose machine learning spatial temporal fusion stf integrated approach order generate day based moda landsat data three schemes random forest machine learning used downscale modis resolution based nine landsat derived indicators including vegetation indices vis land surface temperature lst stf based models including spatial temporal adaptive reflectance fusion model spatio temporal image fusion model used derive synthetic landsat surface reflectance scheme vis scheme scheme landsat unavailable dates approach tested two study sites united states results showed fusion landsat vis produced best accuracy predicted rmse days rrmse high density cloud clear landsat image acquisitions low spatial heterogeneity landsat vis benefit prediction downscaled good agreement modis rmse days rrmse comparison situ measurements showed downscaled higher accuracy modis international society photogrammetry remote sensing inc isprs published elsevier rights reserved
detecting partners direct gaze important aspect social interaction atypical gaze processing reported autism however remains controversial whether children adults autism spectrum disorder interpret indirect gaze direction typical accuracy study investigated whether detection gaze direction toward object less accurate autism spectrum disorder individuals autism spectrum disorder intelligence quotients matched age matched controls asked watch series synthetic faces looking objects decide two objects looked angle formed two possible targets face varied following adaptive procedure order determine individual thresholds found gaze direction detection less accurate autism spectrum disorder control participants results suggest precision gaze following may one altered processes underlying social interaction difficulties autism spectrum disorder
nepal earthquake aftershocks caused huge damage severe loss life property also induced many geohazards major type landslide bring continuous threats affected region gain better understanding landslides induced earthquake proposed pixel based change detection method postearthquake landslide mapping using bitemporal landsat remote sensing data may pre earthquake june postearthquake two river valleys trishuli river valley sun koshi river valley contain important economic arteries linking nepal china selected study areas validation mapping results postearthquake high resolution images google earth shows pixel based landslide mapping method able identify landslides relatively high accuracy also approves applicability landsat satellite landslide mapping multispectral information spatial distribution analysis indicates river valleys substantially affected landslides situation even serious high mountain areas landslides generally found areas high elevation large surface slopes mean values degrees respectively findings suggest areas suffer greatly geohazards threat continue next years
use anti tnf agents associated increased risk tuberculosis anti tnf agents stopped active develops however discontinuation treatment result flare underlying disease charts patients developed active among cohort patients using anti tnf agents reviewed retrospectively patients restarting biologics follow identified one patient miliary died within month biologic agent restarted remaining patients frequently initiated biologic agent etanercept followed rituximab interferon alpha biologic treatment initiated anti treatment four patients completing treatment patients median follow restarting biologics iqr months occurred one patient beh double dagger syndrome initially received etanercept due severe sight threatening uveitis third month anti treatment followed canakinumab months later along methotrexate cyclosporine corticosteroids second course months therapy patient currently stable interferon alpha months restarting anti tnf agents biologic agents even treatment seems possible among patients previously developed anti tnf treatment however risk development infection mandates careful follow
essential establish dynamic model wheeled tractor suspended driver seat including air spring magnetorheological damper analyze vibration characteristics performance equivalent linearized model wheeled tractor always neglects effect nonlinear stiffness scissors linkage driver seat air spring auxiliary chamber well dynamic characteristics real tractor tyre considers driver seat linear spring damper elements causes analysis lower precision considered effect nonlinear stiffness scissors linkage seat air spring auxiliary chamber well damper dynamic characteristics real tyre developed complete nonlinear dynamic model wheeled tractor suspended driver seat including air spring damper experimental results demonstrate improved nonlinear dynamic model consistent actual state equivalent linearized model validity proposed model verified furthermore effect forward speed ratio volume air spring respect volume auxiliary chamber area orifice acceleration wheeled tractor also investigated provide theoretical basis control algorithm design semiactive vibration isolation system
comstock act labeled contraceptive information materials obscene banned distribution issue divided united states divides nation today essay examines press coverage contraception new york times los angeles times two newspapers covered contraception since press coverage reveals contemporary efforts regulate women bodies cloaked discussions affordable care act religious freedom morality employer rights accepting ideology contraception longer reproductive rights issue allowed press exclude women debate power political social religious groups control contraception narrative women lives confirmed lived experience women evolved press coverage least gave women platform speak contraception power appears lost
campus website comprehensive information platform campus informatization using algorithm design campus information system key factors designed handle campus information system problems large error system design end design method campus information system based iot technology put forward method higher vocational college example framework college information system given divided various forms management informatization teaching informatization students network life style basis concept internet things described iot technology core technology information integration variety forms information system available schools integrated give unified data center security authentication center user privilege management center user interface implement design campus information system experiments show design method campus information system based iot technology provides good basis realization campus information construction
concurrent minimization construction cost duration challenging task architects conceptual design using differential evolution study aims obtain optimum design solutions minimize unit cost construction construction duration single family housing projects germany sampled intent developing objective functions regression analysis results suggests able converge set optimum design solutions adequate number generations resemblance descriptive statistics sampled observations results underpins regression models employed develop objective functions presence reliable structured data addition results formal test hypothesis based hypervolume indicator offers rand bin outperforms rand bin irrespective building standard last least solutions offered allows discuss insights regarding design economics
social difficulties autism spectrum disorder asd typically explained disruption shared attention mechanism sam sub component theory mind tom system current paper explore hypothesis sam capacity construct self object relations necessary shared attention arises self categorization process weaker among autistic like traits present participants self categorization shared attention tasks measure autism spectrum quotient results reveal negative relationship shared attention via self categorization suggesting role self categorization disruption sam seen asd implications intervention tom model weak central coherence plays role discussed
practical printed circuit board pcb designs electromagnetic interference emi coupled ground plane commonly shared among analog digital mixed signal integrated circuits noisy ground plane couples interference capacitively pins including output effect exacerbated connected long wires traces routed close conductive ground plane paper reports effect interference coupled capacitively pcb ground plane pins opamp connected voltage buffer simulations illustrate susceptibilities custom operational amplifier designs corroborated measurements several commercial devices measurements show emi induced offset attain considerable values critical emi frequencies lie mhz moreover illustrate considerable susceptibility operational amplifiers electromagnetic interference coupled output pins
computer graphics image processing technologies editing photographs taken user photographic entertainment increased recent years one techniques non photorealistic rendering npr focus study study propose method applying david hockneys photographic collage filtering mobile devices using several well known computer graphics image processing techniques process involves taking sequence images extracting feature points using feature points deform image finally obtain photographic collage using david hockney style generating patchwork
aims evidence suggests ongoing practice variability quality skeletal survey examinations non accidental injury purpose study investigate effects examination quality following implementation imaging checklists method retrospective evaluation skeletal survey examinations carried studies performed january november large district general hospital trust longitudinal assessment undertaken three periods following introduction two versions imaging checklists following modifications examinations assessed scored using three measures completeness quality employing modified established scoring system professional body national standards document results total examinations met inclusion criteria quality assessment measures showed improvements period examination completeness increased median projections throughout three periods mann whitney tests showed significant differences period mean combined anatomy score reduced throughout three periods independent tests mann whitney tests showed significant decrease throughout study period total percentage examination quality increased median throughout three periods independent tests also showed significant differences period conclusion use imaging checklists improve quality support optimal acquisition non accidental injury skeletal survey shows encouraging results however work needed optimise content use checklists practice college radiographers published elsevier ltd rights reserved
accurate inter laboratory comparison ilc concerning electrical quantities low frequency laboratory calibration multifunction electrical instruments national institute metrology research inrim secondary high level electrical calibration laboratory performed satisfactory results instrument involved ilc top class multifunction electrical calibrator chosen wide measurement fields excellent definability requiring therefore small uncertainties calibrate ilc first high accuracy comparison exercise inrim involving grid one hundred thirty measurement points ilc allowed check adequately measurement capabilities techniques uncertainties secondary laboratory attention paid evaluate correlated terms two laboratories measurements calibrator showed high stability resulted appropriate fixed standards digits multimeter aim ilc elsevier ltd rights reserved
conventional mri protocols integral part routine clinical imaging pediatric patients advent several newer mri techniques provides crucial insight structural integrity functional aspects developing brain especially introduction mri systems clinical practice field pediatric neuroimaging continues evolve greater emphasis high spatial resolution faster scan time well quest visualization functional aspects human brain vendors increasingly focusing optimizing technology make suitable children compared adults head size usually smaller demonstrates inherent neuroanatomical differences relating brain development eventual goal advances would evolve potential biomarkers predicting neurodevelopment outcomes prognostication addition utility routine diagnostic therapeutic decision making advanced techniques like diffusion tensor imaging functional mri perfusion spectroscopy volumetric imaging arterial spin labeling add understanding normal brain development pathophysiology various neurological disease processes review primarily focused outlining advanced techniques current potential pediatric neuroimaging applications well providing brief overview advances hardware machine design
voltage one fundamental concepts electrical engineering nevertheless shown difficult concept many students help address difficulties designed tutorial worksheet similar published physics education group university washington activity students introduced electric potential compared contrasted voltage electric potential kirchhoff voltage law closely related assumed learning potential would help students gain better qualitative understanding voltage post test exam data introductory circuits course show tutorial many students still difficulties voltage potential three quarters responses concerning voltage potential inconsistent suggests students unable link two concepts therefore conclude potential voltage remain conceptually different students learning process tutorial worksheets proved effective students overcoming conceptual difficulties likely specific difficulties concepts yet identified
traditional chinese herbal medicine tcm used chinese society years treat diseases inflammation cancer report case nine living aids patients age range treated either unique formula tcm alone tcm switched occasional antiretroviral therapy surprisingly viral loads eight patients undetectable levels june remaining patient low viral load copies counts cells ratios nine patients excellent contributing current good health thus case study suggests tcm potential become functional cure hiv aids
background ustekinumab stelara human monoclonal antibody targeting subunit interleukin indicated moderate severe plaque psoriasis psoriatic arthritis large multicenter prospective trials assessing efficacy safety ustekinumab increased rates severe infections observed far case presentation report case year old woman presenting chills pain swelling right foot dark maculae sole elevated inflammatory markers received third dose ustekinumab due psoriatic arthritis three days admission blood cultures revealed growth staphylococcus aureus imaging showed thickening aortic wall ventral bifurcation right internal iliac artery resembling acute bacterial endarteritis without evidence aneurysms absence foreign bodies decision conservative management made patient received four weeks antibiotic therapy intravenous flucloxacillin followed oral regime levofloxacin rifampicin additional four weeks inflammatory markers resolved promptly patient discharged good health conclusion knowledge first report severe aureus infection patient receiving ustekinumab albeit ustekinumab generally regarded safe drug severe bacterial infections always included differential diagnosis elevated inflammatory markers patients receiving biologicals might present nonspecific symptoms fever might absent effort detect deep seated metastatic infections made prevent complications secure appropriate treatment although risk factors invasive staphylococcal infection like psoriasis recent corticosteroid injection prior hospitalisations present therefore directive causative link aureus bacteraemia ustekinumab drawn considered reporting case worthwhile alert clinicians believe ongoing pharmacovigilance detect increased risks rare severe infections beyond phase phase iii trials patients treated biologicals essential
extensible markup language xml meta language widely used provide non proprietary universal format sharing hierarchical data among different software systems application domains many organizations content providers publishing sharing information xml standard schemas increased popularity cloud application deployment common practice share data schemas underpins integrated applications within cloud environment cloud environment fosters collaboration traditional distributed system direct access update shared files using web based collaboration packages seamless access new technologies smartphones tablet devices since heterogeneous schemas stored cloud tend evolve across time need handle versions adequately paper propose central framework deployed cloud environment aid schema developers standard groups track xml schema changes maintain versions compatibility help enhancement particular schema version framework prototyped tool called xsm store retrieve versioned xsds evaluate based quality indicators defined purpose versioning correctness functionality proposed indicators examined set xsds
china number power station increases quickly according information internet august state environmental protection administration approved thermal power projects installed capacity much thermal power projects approved installed capacity much last year thermal power projects approved january august installed capacity much last year power stations come online chinese installed capacity much billion december growth power stations keeps high levels month whole country generating capacity billion kilowatt hour last year rise winter electricity consumption generating capacity power projects increased quickly genearating capacity power projects december last month january december whole country generating capacity billion kilowatt hour last year january october whole country generating capacity billion kilowatt hour last year generating capacity august largest number billion kilowatt hour last year
objective present work build test solar adsorption refrigeration device adsorbent adsorbate silicagel water pair weather conditions bou ismail algeria refrigeration system proposed study consists three major components solar collector tubular adsorbent bed reflecting surface single glazed cover silicagel material air cooled condenser evaporator supplementary system components working operation parameters cooling adsorption system tested successfully experimental results indicated maximum temperature generated varied degrees degrees average ambient temperature condensing temperature varied degrees degrees degrees minimum evaporator temperature pressure values recorded adsorbent bed heating desorption period varied mbar total energy received around solar adsorption refrigeration device provide solar cop ranging results show practicability solar adsorption refrigeration module favorable design use medical storage areas without electrical network algeria sahara region elsevier ltd rights reserved
year old man presented change behaviour nocturnal enuresis abnormal limb movement headache one week duration diagnosis butterfly glioma glioblastoma multiforme made based imaging characteristics confirmed biopsy findings corpus callosum usually resistant infiltration tumours mass involves crosses corpus callosum suggestive aggressive neoplasm neoplastic non neoplastic conditions may involve corpus callosum mimic butterfly glioma well associated imaging features discussed
modeling identification high dimensional stochastic processes ubiquitous many fields particular growing interest modeling stochastic processes simple interpretable structures many applications econometrics biomedical sciences seems natural describe component stochastic process terms factor variables accessible observation possibly components stochastic process relations encoded graphical way via structured dynamic network referred sparse plus low rank network hereafter problem finding network well dynamic model posed system identification problem paper introduce two new nonparametric methods identify dynamic models stochastic processes described network methods take inspiration regularized estimators based recently introduced kernels stable spline tuned correlated etc numerical examples show benefit introduce structure identification procedure elsevier ltd rights reserved
computer programs constructed facilitate development technological world created different objectives different target platforms result different languages may exhibit significantly different run times performing specific tasks world computer programming instrumental stem education computer languages often utilized perform mathematical calculations classrooms experiment compared different run time speeds python java cygwin linux macair compare languages run times purpose research paper poster demonstrate test analyze utilize knowledge varying speeds languages promote educational use computer languages data applied utilizing certain languages paired different platforms enhance accelerate student learning classroom
paper describes development microgasturbine rotor diameter target electrical power output lies around total system fits cylinder diameter length system contains components large gasturbine generator compressor recuperator combustion chamber turbine electrical generator major challenges high rotational speed min high turbine inlet temperature efficiency components small dimensions flow compressor turbine characterized relatively low reynolds numbers higher flow losses inherently lower efficiency require higher blade tip speed large turbines minimize wear frictional losses rotor mounted aerodynamic bearings withstand high centrifugal stresses high strength steel used compressor shaft turbine made sin tin ceramic composite withstand combination elevated stress temperature
emotion regulation examined extensively regard important outcomes including psychological physical health however literature includes many different emotion regulation strategies little examination relate one another making difficult interpret synthesize findings goal meta analysis examine underlying structure common emotion regulation strategies acceptance behavioral avoidance distraction experiential avoidance expressive suppression mindfulness problem solving reappraisal rumination worry evaluate structure light theoretical models emotion regulation also examined distress tolerance important emotion regulation ability relates strategy use conducted meta analyses estimating correlations emotion regulation strategies based samples effect sizes well distress tolerance strategies resulting meta analytic correlation matrix submitted confirmatory exploratory factor analyses none confirmatory models based prior theory acceptable fit data exploratory factor analysis suggested underlying factors best characterized data two factors labeled disengagement aversive cognitive perseveration emerged strongly correlated distinct factors latter consisting putatively maladaptive strategies third factor adaptive engagement less unified factor weakly related factors distress tolerance closely associated low levels repetitive negative thought experiential avoidance high levels acceptance mindfulness discuss theoretical implications findings applications emotion regulation assessment
paper presents methodological solution battle background leakage assessment water networks bblawn competition methodology employs two constrained multiple objective optimization problems implemented context software application generic hydraulic optimization benchmarking water distribution system wds problems objectives combined infrastructure operational costs system wide leakage minimized order accelerate evaluation potential solutions distributed computing approach permits multiple epanet solutions evaluated parallel pressure driven demand extension epanet assists optimization accurately ranking near feasible solutions dynamically allocate leakage demand nodes pressure reducing valves prvs located two ways priori respect optimization analysis posteriori infrastructure optimization reduce excess pressure pipe leakage latter demonstrates better overall fitness leading optimal configurations dominating obtained former several temporal resolutions prv settings evaluated contrast optimal solutions computational effort required american society civil engineers
scarcity water pollution load political issues rising population drawn great attention proper management water resources groundwater century evaluation groundwater quality critical element assessment water resources quality potability water consumed defines baseline protection many diseases infections present study aims calculate water quality index wqi analysis seven physicochemical parameters according national sanitation foundation nsf assess suitability water drinking irrigation purposes human uses present investigation ten groundwater samples collected various parts seraidi municipality area located north east algeria physico chemical parameters temperature dissolved oxygen phosphates nitrates turbidity fecal coliforms analyzed overall wqi values samples found range reveals fact quality samples medium good could used drinking domestic uses proper treatment
degree knowledge influences visual perceptual processes question central seeing versus thinking debate cognitive science often discussed using examples claimed proof one stance another however also muddled usage different unclear definitions perception well defined process perceptual organization argue including speed efficiency equation opens new perspective limits top influences thinking seeing input perceptual organization process may modifiable output enrichable process seems fast efficient thinking hardly time intrude effective mostly fact
methyl aspartate receptors nmdars major targets acute chronic alcohol well regulators plasticity number brain regions aberrant plasticity may contribute treatment resistance high relapse rates observed alcoholics recent work suggests chronic alcohol treatment preferentially modulates expression subcellular localization nmdars containing glunb subunit signaling synaptic extrasynaptic glunb nmdars already implicated pathophysiology various neurological disorders nmdars interact large number proteins glutamate synapse better understanding alcohol modulates proteome needed employed discovery based proteomic approach subcellular fractions hippocampal tissue chronic intermittent alcohol cie exposed cbl mice gain insight alcohol induced changes glunb signaling complexes protein enrichment analyses revealed changes association post synaptic proteins including scaffolding glutamate receptor pdz domain binding proteins glunb particular glunb interaction metabotropic glutamate mglu receptor dependent long term depression ltd associated proteins arc homer increased glua decreased accordingly found lack mglu induced ltd adrenergic receptor induced ltd remained intact hippocampal following cie data suggest cie specifically disrupts mglu ltd representing possible connection nmdar mglu receptor signaling studies demonstrate new way alcohol modulate plasticity hippocampus also emphasize utility discovery based proteomic approach generate new hypotheses regarding alcohol related mechanisms
voters associate female candidates feminine stereotypes voters also associate female candidates qualities valued political leaders experience knowledge current research offers conflicting conclusions whether female candidates benefit breaking feminine norms face backlash aggressive likable enough using series experiments show counterstereotypic gender strategies including women emphasizing masculine trait competencies improve evaluations female candidates along masculine feminine leadership dimensions results offer novel insights female candidates overcome perceptual deficits among voters lack critical masculine leadership qualities also show female candidates overcome biases without losing traditional feminine strengths warmth likability however counterstereotypic female candidates face likability backlash partisan voters findings suggest counterstereotypes may beneficial female candidates primary election context voters copartisans rather general elections candidates often need cross partisan support
background anxiety disorders highly prevalent people bipolar disorder clear many anxiety disorders even times free major mood episodes aimed establish proportion euthymic individuals bipolar disorder meet diagnostic criteria anxiety disorders method performed random effects meta analysis prevalence rates current dsm iii dsm defined anxiety disorders panic disorder agoraphobia social anxiety disorder generalized anxiety disorder specific phobia obsessive compulsive disorder post traumatic stress disorder anxiety disorder otherwise specified euthymic adults bipolar disorder studies published december results across samples individuals bipolar disorder met diagnostic criteria one anxiety disorders euthymia confidence interval direct comparison euthymic individuals bipolar disorder population controls across three studies showed fold increase risk ratio prevalence anxiety disorders bipolar disorder conclusions findings suggest anxiety disorders common people bipolar disorder even mood adequately controlled euthymic people bipolar disorder routinely assessed anxiety disorders anxiety focused treatment initiated indicated
explore impact game changers dynamics innovation time three problem domains wilderness protection women rights assimilation indigenous children canada taking specifically historical cross scale approach look one social innovation problem domain explore origins history development national parks usa legalization contraception usa canada residential school system canada based comparison cases identify three kinds game changers catalyze social innovation define seminal disrupt continuity social innovation label exogenous shocks provide opportunities novel combinations recombinations label endogamous game changers
sleep considered new frontier performance enhancement article presents background content sleep function sleep needs methods sleep investigation along data potential effects ramadan fasting sleep normal individuals athletes accumulated sleep loss negative impacts cognitive function mood daytime sleepiness performance sleep studies athletes fasting ramadan rare demonstrated month sleep duration decreased sleep timing shifted direct relation sleep changes performance ramadan yet elucidated objective sleep patterns investigated using polysomnography actigraphy standardised questionnaires recorded daily journals sleep logs available data sleep indicate team doctors coaches consider planning sleep schedule napping implementing educational programmes focusing need healthy sleep consider routine screening sleep loss athletes age groups genders
standard pet scintillation detection energy timing location incoming photon recovered using analog signal processing techniques energy location information processed using analog digital adc converter samples analog value proportional integral charge created scintillation event propose change paradigm modulate width rather amplitude digital pulse proportional integral charge created analog value outgoing digital pulses recovered using time digital converter tdc back end electronics without need adc note new scenario tdc used record time event used recover amplitude main performance parameter must optimized dynamic range versus dead time front end detector goal bit dynamic range pulse width modulation pwm scheme adequate high resolution pet systems based semiconductor detectors avalanche photodiodes apd cadmium zinc telluride czt novel circuit designed fabricated tested proposed pwm readout scheme circuit different previously developed time threshold pulse width modulation circuits used high energy physics pwm techniques simplify routing back end electronics without degrading performance system readout architecture based pwm processes digital rather analog pulses easily multiplexed enabling one achieve high channel density required ultra high resolution positioning pet detector systems
paper describes novel analog circuit extracting tilt angle output linear micro electromechanical system accelerometer circuit uses accelerometer signal together gravitational acceleration vector generate tilt signal using current mode representation metal oxide semiconductor devices operating weak inversion appropriate trigonometric function realized compute tilt furthermore implementing long time constant filter extract mean tilt level provides adaptation static tilt level specifically circuit designed part implantable vestibular prosthesis provide inclination signals bypassing dysfunctional otolith end organs circuit fabricated austriamicrosystems complementary metal oxide semiconductor technology paper presents theory implementation measured results
whether superiors subordinates accurate assessing emotions others aka emotion recognition accuracy era question gained much interest yielded decidedly mixed empirical results present study investigates whether superiors subordinates actual hierarchical relationship differ era investigated superiors recruited one direct subordinates total superiors subordinates took paper pencil version standardized era test results showed superiors accurate assessing emotions persons subordinates
background recently marcus bioinformatics proposed use compressed bruijn graph describe relationship genomes many individuals strains closely related species devised log time algorithm called splitmem constructs graph directly without using uncompressed bruijn graph based suffix tree total length genomes length longest genome baier bioinformatics improved result results paper propose new space efficient representation compressed bruijn graph adds possibility search pattern allele variant form gene within pan genome ability search within pan genome graph utmost importance design goal pan genome data structures
study investigated structural biomechanical fractographic features rib fractures piglet model test hypothesis fist impact apart thoracic squeezing may result lateral costal fractures observed abused infants mechanical fist accelerometer constructed fixed custom jig twenty stillborn piglets supine position impacted thoracic cage resultant force versus time curves accelerometer data showed number steps indicative rib fracture correlation impact force number fractures statistically significant pearson fractures visualized completely pierced parietal pleura thoracic wall butterfly fracture patterning scanning electron microscopy showed complete bone fractures zone impact normal axis ribs incomplete vertical fractures bifurcation occurred periphery contact zone work suggests mechanism rib failure fist impact typical transverse fracture pattern anterolateral region associated cases non accidental rib injury impact events investigated velocity similar approximately times faster previous quasi static axial bending tests squeezing infantile may induce buckle fractures anterior well posterior region highly flexible bones fist punch impact event may result anterolateral transverse fractures hence findings suggest presence anterolateral rib fractures may result impact rather manual compression elsevier ltd rights reserved
purpose investigate breastfeeding initiation duration affect likelihood overweight obese children aged design cross sectional data national survey children health setting rural urban areas united states subjects households least one member ages sample size measures parent reported body mass index breastfeeding initiation duration covariates gender family income education ethnicity child care attendance maternal health physical activity residential area analysis partial proportional odds models results early childhood breastfed children higher probability normal weight lower probability obese compared children never breastfed children breastfed less months lower probability normal weight higher probability obese respect children breastfed months conclusion study findings suggest length breastfeeding whether exclusive may associated lower risk obesity early childhood however caution needed generalizing results limitations analysis based findings study others breastfeeding promotion policies cite potential protective effect breastfeeding weight early childhood
anti inf alpha therapies used treatment different inflammatory conditions inflammatory bowel disease ibd however paradoxical effects may occur treatment words drugs induce unmask diseases similar intended treat etanercept main anti inf alpha agent associated development paradoxical ibd drug moreover proven usefulness treatment disease association coincidental meets criteria temporal causal association infrequent seen particularly patients spondyloarthritis restarting treatment etanercept may induce new intestinal symptoms endoscopic histopathologic clinical differences primary secondary ibd diagnosed way frequent presentation crohn disease paradoxical event occurs etanercept usually replaced infliximab associated disease recurrence elsevier espana aeeh aeg rights reserved
background gender reflects social norms women men whereas sex defines biological characteristics gender related characteristics explain differences access care premature acute coronary syndrome acs whether associated cardiovascular outcomes unknown objectives study estimated associations gender sex recurrent acs major adverse cardiac events mace acs cardiac mortality revascularization months patients acs methods studied women men age years genesis praxy gender sex determinants cardiovascular disease bench beyond premature acute coronary syndrome prospective observational cohort study hospitalized acs january april gender related characteristics social roles assessed using self administered questionnaire composite measure gender derived outcomes included recurrent acs mace months results feminine roles personality traits associated higher rates recurrent acs mace compared masculine characteristics difference persisted recurrent acs multivariable adjustment hazard ratio score confidence interval nonstatistically significant trend mace hazard ratio confidence interval possible explanation increased anxiety condition prevalent patients feminine characteristics rendered association gender recurrent acs nonstatistically significant hazard ratio confidence interval female sex associated outcomes post acs conclusions younger adults acs feminine gender increased risk recurrent acs months independent female sex american college cardiology foundation
solar radiation valuable green energy important achieving successful building design thermal comfort indoor environment paper considers solar radiation indoors transient thermal transfer models clothed human body offers new numerical method analyze dynamic thermal status clothed human body different solar radiation incidences evaluation model solar radiation indoors group coupled thermal models clothed human body developed integrated simulation capacities integrated models validated comparison predicted results experimental data reference simulation cases also conducted show influence solar radiation thermal status individual clothed body segments human body staying indoors different seasons numerical simulation method provides useful tool analyze thermal status clothed human body different solar radiation incidences indoors thus enables architect efficiently utilize green solar energy building development published elsevier ltd
although phosphorus essential element needed lives excess harmful environment objective study aims determine flows fisheries sector thailand consisting sea freshwater activities captures cultures currently annual fisheries catch averages comes marine capture followed coastal aquaculture freshwater aquaculture inland capture total contained fresh products directly sold local markets consumption sent processing factories prior sold local markets exported quantities entering fisheries sector come captures import fisheries products feed produced agriculture input fisheries sector found average based past ten year records total input captures accounts represents aquatic feeds agriculture animal manures obtained imports fishery products coastal freshwater aquacultures found consumers feeds almost produced agricultural crops grown inland moreover activities cause losses approximately account total loss fisheries sector overall fisheries sector found mobilize three channels consumed within country exported lost ecosystem based results work recommended future research directed ways minimize loss maximize recycle thailand fisheries sector enhance food security curtail water pollution elsevier ltd rights reserved
university students seek counseling discuss concerns academic skills motivation time management well article examines conversational activity normalizing recurrently used counselors manage students negative emotions troubles telling normalizing refers activity something interaction made normal labeling normal commonplace interpreting ordinary way three uses normalizing identified sample videotaped counseling sessions supporting student position challenging student presenting student problem workable argue normalizing means addressing students problematic emotions offering support yet way maintains orientation toward problem solving furthermore normalizing seems serve affiliation suggesting problems unique treated either delicate problematic counselors students
background sige sigg detection necessary accurate effective type hypersensitivity diagnostics estimation disease development typically analyses antibodies performed separately help various specialized systems aim study develop microarray based method simultaneous quantitative detection sige sigg common allergens single sample methods quantitative method simultaneous detection sige sigg developed based technology hydrogel microchips previously designed engelhardt institute molecular biology russian academy sciences eimb ras microarray contained gel pads immobilized allergens gel pads allow obtaining sige sigg internal calibration curves allergen assay possibility simultaneous detection sige sigg developed using corresponding fluorescent dyes results multiplex immunoassay method using hydrogel microarrays developed study allowed quantitative detection sige sigg allergens different groups single assay comparison microarray existing plate based analogues allerg liq sigg elisa performed analysing blood serum samples evaluating pearson correlation coefficients roc analysis passing bablok linear regression results conclusion implementation method allergy diagnostics provide possibility simultaneously performing primary patient screening obtaining additional information concerning severity allergies choice appropriate therapy
background aviation classic example high reliability organization hro organization catastrophic events expected occur without control measures health care systems transition toward high reliability aviation practices increasingly transferred clinical implementation methods pubmed search using terms aviation crew resource management patient safety undertaken manuscripts authored physician pilots accident investigation regulations analyzed subject matter experts involved adoption aviation practices medical field interviewed results pubmed search yielded results relevant inclusion improved clinical outcomes noted five research trials aviation practices adopted particularly regard checklist usage crew resource management training effectiveness interventions influenced intensity application leadership involvement provision staff training usefulness incorporating mishap investigation techniques established whereas aviation accident investigation highly standardized investigation medical error characterized variation discussion adoption aviation practices clinical medicine facilitates evolution toward high reliability evidence efficacy checklist crew resource management training robust transference aviation accident investigation practices preliminary standardized independent investigation process could facilitate development safety culture commensurate achieved aviation industry
subjective indicators building dampness consistently linked health best semi quantitative objective quantitative assessments dampness also needed study dampness related health effects investigators readily non destructively measure moisture content building materials hand held moisture meters however indicate amount water material available microorganisms growth water activity unfortunately readily measurable field relatable unless previously determined experimentally moisture meter reading differ across materials well moisture adsorption desorption determine correspond levels stable air relative humidities generated glove box saturated aqueous salt solutions gypsum board relative humidity chamber air tracked reached equilibrium strong correlations observed meter readings gravimetrically determined among readings three moisture meters meter readings gypsum board
paper dvcc based operational amplifier proposed pole introduced transfer characteristic dvcc integrated capacitor amp composed chip dvcc one integrated nmos resistor capacitor cmos voltage follower bandwidth dvcc amp adjusted voltage tuning resistor conventional voltage mode operational amplifiers suffer introduction second pole high frequencies thus rendering circuits suitable low frequency applications proposed dvcc amp large signal bandwidth operate wide range frequencies bandpass filter tested using reported amp pspice theoretical analysis presented
rationale familial sinus node atrioventricular conduction dysfunction rare disorder leads paroxysmal dizziness fatigue syncope temporarily permanently reduced heart rate date genes familial sinus atrioventricular conduction dysfunction known majority cases remain pathogenically unresolved objective aim identify disease gene large generation family autosomal dominant sinus node dysfunction snd atrioventricular block avb characterize mutation related pathomechanisms familial snd avb methods results genome wide linkage analysis mapped snd avb disease locus chromosome point logarithm odds score region targeted exome sequencing identified novel heterozygous mutation argleu gnb gene strictly cosegregated snd avb phenotype gnb encodes beta subunit beta heterotrimeric protein complex released protein coupled receptors vagal stimulation heterologous expression systems hek cells xenopus laevis oocytes enhanced activation protein activated channel girk kir kir shown mutant beta coexpressed contrast coexpression mutant beta cardiac ion channels hcn hcn cav molecular dynamics simulations suggested reduced binding property mutant beta cardiac girk channels compared native beta conclusions gnb gene mutation associated familial snd avb leads sustained activation cardiac girk channels likely hyperpolarize myocellular membrane potential thus reduces spontaneous activity findings describe first time role mutant protein nonsyndromic pacemaker disease girk channel activation
scalable liquid metal cooled small modular slimm reactor design concept recently developed university new mexico institute space nuclear power studies generates mwth full power years respectively without refueling natural circulation vessel liquid sodium cools reactor core nominal steady state operation shutdown aid vessel chimney tall annular heat exchanger hex concentric helically coiled tubes natural circulation thermal hydraulics model slimm reactor developed investigate effects thermal power vessel chimney height hex design circulation rate core exit temperature vessel liquid sodium pressure losses steady state operation hex design parameters investigated number pitch tube diameter helical coils temperature pinch vessel sodium flow downcomer secondary sodium flow hex coils increasing reactor thermal power vessel chimney height increases flow rate vessel liquid sodium natural circulation decreases exit temperature reactor core conversely increasing number tube diameter hex helical coils decreases flow rate vessel liquid increases exit temperature reactor core decreases hex total height depending steady state reactor thermal power hex design vessel sodium flow reactor core contributes similar total pressure losses sodium flow hex contributes similar respectively elsevier ltd rights reserved
dimensional nanosheets graphene graphene oxide boron nitride transition metal dichalcogenides produced large scale exfoliation techniques lateral shape materials typically considered random irregular average size often estimated using techniques characterized strong approximations poor statistical significance measure quantitative objective way size shape monoatomic nanosheets using combination optical electronic scanning probe techniques measure one one size shape thousands sheets graphene oxide undergo standard ultrasonication treatment using automatic image processing statistical modelling identify two different fragmentation processes nanoscale related two populations nanosheets described gamma exponential size distributions respectively two populations sheets coexist fragmentation process one retaining average size shape results explain size reduction commonly observed nanosheets upon sonication effect changes respective weights two populations nanosheets present material
background freedom discrimination one key principles human rights based approach maternal newborn health objective review published evidence discrimination romani women maternity care europe interventions address search strategy systematic search eight electronic databases undertaken using terms roma maternity care broad search grey literature included websites relevant agencies data extraction synthesis standardised data extraction tables utilised quality formally assessed line argument synthesis developed tested data grey literature results nine hundred papers identified three qualitative studies seven sources grey literature met review criteria revealed many romani women encounter barriers accessing maternity care even able access care experience discriminatory mistreatment basis ethnicity economic status place residence language grey literature revealed health professionals held underlying negative beliefs romani women published research studies examining effectiveness interventions address discrimination romani women infants europe roma health mediation programme promising intervention identified grey literature conclusions evidence discrimination romani women maternity care europe interventions address discrimination childbearing romani women underlying health provider prejudice urgently needed alongside analysis factors predicting success failure initiatives
paper presents operational transconductance amplifier realized using floating gate mosfets used neuron activation function wide linear range adaptable threshold level slope circuit suitable analog signal processing neural network applications circuit generates log sigmoid tan sigmoid naf functions simultaneously circuit parameters naf function easily changed changing voltage control gate fgmosfet linear range proposed fgmosfet based ota circuit large equal power supply power analysis noise analysis proposed circuit performed mismatch study performed using monte carlo simulation tspice simulation results using well process presented layout design circuit done using edit tanner tool
fault cutting algorithm important applying three dimensional numerical manifold method engineering simulation paper presents primary approach fault cutting algorithm including data structures fault cutting procedures basic computing algorithms first data structures physical elements mathematical covers proposed single linked lists linked list arrays respectively reduces complexity algorithm increases efficiency connecting physical elements covers second strategy recording cutting traces every two faults ensure model agrees actual situation proposed strategy also reduces complexity improves efficiency third mathematical covers physical elements cut faults independently process complete cutting instances multiblock form incomplete cutting instances without forming new irrational block finally four cutting examples presented demonstrate proposed fault cutting algorithm correct useful american society civil engineers
failure mechanisms materials intrinsically intertwined nonhomogeneity randomness fine scales using mean field data heterogeneous materials homogeneous materials based fracture models might result prediction unrealistic smooth crack trajectories consequently unreliable load carrying capacity study aims develop heterogeneous cohesive crack model predict macroscopic strength materials based meso scale random fields fracture properties characterizing spatially varying fracture properties random fields heterogeneous cohesive crack propagation simulated predict realistic crack paths reliably assess macroscopic load carrying capacity new stress based criterion determine crack growth direction developed taking account crack tip stress state heterogeneity tensile strength concrete beam subjected mixed mode fracture modelled benchmark example demonstrate crack model numerical simulation reveals crucial fracture phenomena tortuousness crack trajectories effectively captured model effects various important parameters crack paths peak loads macroscopic ductility overall reliability including variance random fields correlation length shear fracture resistance investigated discussed criticality crack propagation incremental length fracture modelling random heterogeneous materials especially highlighted elsevier rights reserved
climate change expected exacerbate drought many plants making drought tolerance key driver species ecosystem responses plant drought tolerance determined multiple traits relationships among traits either within individual plants across species evaluated general patterns across plant diversity synthesized published data stomatal closure wilting declines hydraulic conductivity leaves stems roots plant mortality woody angiosperm gymnosperm species evaluated correlations among drought tolerance traits across species general sequence water potential thresholds traits within individual plants trait correlations across species provide framework predicting plant responses wide range water stress one two sampled traits increasing ability rapidly characterize drought tolerance across diverse species analyzing correlations also identified correlations among leaf stem hydraulic traits wilting point turgor loss point beyond expected shared ancestry independent associations water stress alone average angiosperm species generally exhibited sequence drought tolerance traits expected limit severe tissue damage drought wilting substantial stem embolism synthesis relationships among drought tolerance traits provides crucial empirically supported insight representing variation multiple traits models plant ecosystem responses drought
paper deals electrical modeling lithium ion polymer battery complementary characterization tests first aim work understand electrical behavior battery experimentations environmental conditions final application ones second goal work identify battery models different precision levels implement specific models considered aircraft electrical network paper two equivalent electrical circuit models presented quasi static model functional sufficient electrical energy management aircraft dynamic model behavioral necessary analysis embedded network quality identification parameters carried adapted characterization tests chronopotentiometry constant current electrochemical impedance spectroscopy different temperatures complementarity tests particularly underlined paper useful parameter identification results model simulation experimentation compared mission profile analyzed eventually paper presents complete experimental data commercial lithium ion polymer battery including temperature influence elsevier ltd rights reserved
several approaches proposed literature offering rdf views databases addition variety tools exist allow exporting database contents rdf graphs approaches latter category often proved demonstrating better performance ones former however database contents exported rdf always optimal even necessary export dump procedure often called whole database contents every time paper investigates problem incremental generation storage rdf graph result exporting relational database contents order express mappings associate tuples source database triples resulting rdf graph implementation rrml standard subject testing next methodology proposed described enables incremental generation storage rdf graph originates source relational database contents performance methodology assessed extensive set measurements paper concludes discussion regarding authors important findings
although parenting two parent families increasingly important area research little known parenting conversation crucial aspect parenting study used grounded theory methodology explore chinese singaporean parents perceive parenting conversations light influence families origin interviews conducted mothers fathers sixteen families findings revealed central category conversations along parenting journey two main categories conversations connect collaborate parenting conversations family heritage practices substantive theory parenting conversation process generated synthesis findings study serves foundation future research parenting conversation implications clinicians researchers presented discussed
chronic inflammation associated obesity plays major role development metabolic diseases cancer autoimmune diseases among subsets cells involved pathogenesis autoimmune disorders psoriasis rheumatoid arthritis inflammatory bowel disease steroid resistant asthma multiple sclerosis accumulating data suggest reciprocal interactions metabolic systems immune system play pivotal roles pathogenesis obesity associated diseases herein outline developing principles control cell differentiation function via cellular metabolism also discussed recent findings changes intracellular metabolism including fatty acid metabolism affect cell function obese individuals finally also highlight unique molecular mechanism involved activation retinoid related orphan receptor gamma ror gamma intracellular metabolism discuss new therapeutic approach treating autoimmune disorders inhibition ror gamma
based classical drug design theory novel series gentiopicroside derivatives designed synthesized synthesized compounds biologically evaluated inhibition influenza virus anti hcv activity vitro gentiopicroside derivatives showed interesting anti influenza virus activity respectively however significant anti hcv activity found gentiopicroside derivatives preliminary results indicate modification sugar moiety gentiopicroside helpful enhancing anti influenza activities works demonstrate importance secoiridoid natural products new leads development potential antiviral inhibitors elsevier masson sas rights reserved
aim sub threshold psychotic experiences pes common general population may increase risk psychological distress psychosis onset generating need effective community screening instruments study aimed explore utility brief self report psychosis risk screening tool predicting perceived need psychological treatment among non clinical sample beyond accounted accompanying forms psychopathology trait neuroticism methods construct validity predictive validity test retest reliability brief self report questionnaire screening putative prepsychotic states determined among college students multiple linear regression analyses conducted explore relationship pes perceived need psychological services results exception auditory perceptual disturbances pes significantly associated one need services belief others services needed controlling neuroticism anxiety depressive symptoms auditory perceptual disturbances significantly associated perceived need psychological services even accounting additional symptoms conclusions results confirm usefulness psychosis risk screening tool evaluating presence sub threshold pes particularly auditory perceptual disturbances relationship pes perceived need psychological services however largely explained existence neurotic traits anxiety depressive symptoms screening auditory perceptual disturbances may useful identifying unmet clinical need among young adults
background cardiac fibrosis play key role atrial fibrillation pathogenesis underlying potential molecular mechanism still understood however potential mechanisms mir upregulation role cardiac fibrosis remain unclear controls cell proliferation processes fundamental disease progression methods study immunohistochemistry real time pcr cell transfection cell cycle cell proliferation western blot used respectively results demonstrated tumor suppressor cell adhesion molecule cadm potential target mir study revealed mir regulation cadm expression decreased cardiac fibroblasts fibrosis tissue cardiac fibroblasts transfected mir mimic promoted mir overexpression enhanced stat expression decreased cadm expression nevertheless cardiac fibroblasts transfected mir inhibitor obtained opposite expression result furthermore downexpression mir suppressed cardiac fibroblast proliferation conclusions results suggested mir overexpression promotes cardiac fibrosis via stat signaling pathway decrease cadm expression indicating mir important signaling molecule cardiac fibrotic remodeling
hysteresis poses significant challenge control smart material actuators unaccommodated hysteresis result oscillation poor tracking performance potential instability actuators incorporated control design overcome problems fundamental idea coping hysteresis inverse compensation based preisach model paper address systematically problem preisach model inversion properties employing technique three step composition mapping geometric interpretation preisach model preisach right inverse achieved via iterative algorithm proposed possesses properties preisach model finally comparative experiments performed piezoelectric stack actuator pea test efficacy compensation scheme based preisach right inverse
high speed machining advanced technology significantly developmental potential due drastic market competition development new materials improved demand component quality shortening product life cycle complexity product development manufacturing equipments high speed machining hsm technology develops rapidly process hsm conception industrialization realized hsm technology plays important role chinese aviation article hsm technology application aerial manufacturing introduced summarizing key factors hsm current application innovative mode manufacturing engineering management hsm proposed mode achieve optimization cost
understanding real world driving conditions form driving cycles instrumental design efficient powertrains energy storage systems electric vehicles addition driving cycles serve standardised measurement procedure certification vehicle fuel economy driving range also facilitate evaluation economic lifecycle costs emerging vehicular technologies however discrepancies existing driving cycles real world driving conditions exist due number factors insufficient data inadequate driving cycle development methodologies methods assess representativeness developed driving cycles novel aspect work presented use real world data electric vehicles six month period derive driving cycle appropriate assessment stochastic statistical methodology used develop assess representativeness driving cycle separate set real world electric vehicle driving data developed cycle performs well comparison although direct comparisons internal combustion engine driving cycles informative relevant due marked differences electric vehicles operate discussion around developed electric vehicle cycle relates also included elsevier ltd rights reserved
power loss reduction one main targets electrical energy distribution company paper problem joint optimization topology network parameters real smart grid faced portion italian electric distribution network managed acea distribuzione located rome considered includes user loads lines feeders thyristor voltage regulator distributed energy sources generator sets photovoltaic plant power factor correction pfc performed tuning generator sets setting state breakers order perform distributed feeder reconfiguration dfr dfr paper introduce simplified graph representation electrical network propose new algorithm find radial network configurations pfc dfr optimization faced defining solving suited multi objective optimization problem adopting genetic algorithm tests performed feeding simulation environment real data concerning dissipated generated active reactive power values first results interesting showing considering possible admissible network configurations help optimization procedure finding better solutions
classic evolutionary social exchange perspectives suggest people mate value others possess desirable traits attractiveness status intrinsic individual article broadens mate value ways incorporate relational perspectives first close relationships research suggests alternative measure mate value whether someone provide high quality relationship second person perception research suggests trait based relationship quality measures mate value contain mixture target variance consensus targets classic conceptualization relationship variance unique ratings targets study participants described personal conceptions mate value revealed themes consistent classic relational approaches study used social relations model blocked design assess target relationship variances participants romantic evaluations opposite sex classmates beginning end semester study one many design documented target relationship variances among long term opposite sex acquaintances results generally revealed relationship variance target variance participants romantic evaluations likely unique particular person rather consensual furthermore relative dominance relationship target variance stronger relational measures mate value relationship quality projections classic trait based measures attractiveness resources finally consensus decreased participants got know one another better long term acquaintances study revealed enormous amounts relationship variance implications evolutionary close relationships person perception literatures discussed
novel duct silencer developed using dielectric elastomer absorbers deas dielectric elastomer lightweight high elastic energy density large deformation high voltages smart material used fabricate new generation actuator acoustic performances duct silencer experimentally investigated transmission loss measurement system using two load method found resonance peaks new duct silencer could controlled applying various voltages maximum resonance shift resonance peaks achieved indicated duct silencer could adjusted absorb broadband range noise without addition mechanical part furthermore resonance shift multiple resonances mechanisms using deas proposed discussed present paper aiming achieve broadband noise reduction present results also provide insight appropriateness absorber possible use new acoustic treatment replace traditional acoustic treatment
given public health importance depression identification prevention programs long term effects reducing rate depression critical importance examination factors may moderate magnitude prevention effects study examines impact family check delivered public secondary schools beginning sixth grade development major depression adulthood aged multilevel intervention program included universal classroom based intervention focused problem solving peer relationship skills family check selected brief assessment based intervention designed motivate parents improve aspects family functioning warranted family management treatment indicated focused improving parenting skills demographic gender ethnicity baseline risk factors family conflict academic problems antisocial behavior peer deviance examined possible moderators logistic regression analyses intervention effects depression moderated baseline family conflict academic performance stronger intervention effects youth low grade point averages low conflict families baseline findings extend emerging literature prevention programs long term effects depression highlight directions future research enhance effects
examine requirements available methods software provide imitate uniform random numbers parallel computing environments context great majority applications independent streams random numbers required computed single processing element time sometimes thousands even millions streams needed explain produced managed devote particular attention multiple streams gpu devices author published elsevier behalf international association mathematics computers simulation imacs
three experiments examined impact partner age magnitude socially suggested false memories young participants recalled household scenes collaboration implied young older adult partner intentionally recalled false items experiment participants presented age partner low age salience context experiment participants presented age partner along photograph biographical information partner high age salience context experiment age salience varied within experiment across experiments participants low age salience high age salience contexts incorporated partners misleading suggestions subsequent recall recognition reports thus demonstrating social contagion implied partners importantly effect partner age differed across conditions participants high age salience context less likely incorporate misleading suggestions older adult partners young adult partners participants low age salience context equally likely incorporate suggestions young older adult partners participants discount memory older adult partners age highly salient
paper hydraulic performance self healing capacity geotextile clay liners containing various amounts nano clay studied nano clay employed substitute portion bentonite comparison hydraulic performance self healing capacity common geotextile clay liners geotextile clay liners without additives also experimentally studied novel instrument developed evaluate self healing capacity geotextile clay liners samples atterberg limits free swell index neat modified clayey samples also measured experimental results showed nano clay considerably reduces hydraulic conductivity geotextile clay liners also improves self healing capacity geotextile clay liners free swell index liquid limits bentonite specimens containing nano clay considerably higher normal specimens concluded factors affecting free swell index bentonite change self healing capacity geotextile clay liners study specimen containing nano clay showed best performance hydraulic conductivity self healing capacity among specimens final effect nano clay inclusion permeability bentonite showed analytical model using results surface tension measurements
use indicators fast widely spread way monitor groups children health wellbeing indicators useful research also important tools planners politicians although constructed simplify reality many reports still offer complex confusing picture least sheer numbers although constructed simplify reality many reports still offer complex confusing picture least sheer numbers therefore increasing demand even simplifications indicators combined single summary numbers composite indices time composite index summarizes complex sometimes elusive process making accessible advocacy political interventions combining dissimilar components makes results difficult interpret use obvious dilemma need rigour evidence research orientation wish simple summarizing overview findings policy orientation models created form indicator sets either combining simple addition weighting leaving separate indicators index systems operation use equal weighting system standardization components selected examples models described well pros cons summary suitable ways handling problems indicators composite indices offered surveys taken best different approaches presenting results summary index great picture subindices various domains child health separate indicators detailed study basic components swedish child health index presented example solution
background health risk assessments hras implemented studied decades various settings little known effect introducing hras dynamics content patient clinician conversations medicare annual wellness visits awvs whether effective use hras requires additional training resources methods used conversation analysis techniques analyze awvs conducted academic family medicine residency practice month baseline period low intensity intervention implemented explore improvements dynamics content conversations short exit interviews patients clinicians evaluated standard content analytic techniques results six overarching themes emerged described dynamics awv conversations patients clinicians sub optimally utilized hra report missed many opportunities promoting behavior change however low intensity multi component intervention significantly decreased proportion clinician talk time per visit increased proportion patient talk time robustly increased number duration change talk increased number patient cut ins tended increase number duration clinician advice talk patients felt informed empowered motivated hra enhanced wellness visit clinicians found process helped construct effective visit agenda facilitated convergence patient goals evidence based recommendations conclusions study suggests hras introduced without proper framing education additional resources may allow patients clinicians leverage awvs effective health planning improvement targeted low intensity intervention may help patients clinicians improve quality hra guided health conversations awvs
fuel prices tightening emission standards challenged dominance internal combustion engines response changed business context automotive industry shown active interest waste heat recovery technologies seen rapid development recent years paper uses literature review patent landscape analysis study key emerging technologies field namely thermoelectric generators rankine cycle organic rankine cycle systems state art review highlights challenges advantages future prospects selected technologies patent analysis reveals leading countries principal technological development indicators important actors active field results indicate growing trend patenting selected technologies united states japan far dominant countries waste heat recovery area although relative share patent applications declining applying patent landscape approach study offers quantitative perspective current developments waste heat recovery technology provides indicators future trends contributes debate technological competition automotive industry based conducted analyses thermoelectric generators seems developed alternatives closest commercial application rankine cycle based technologies although less well developed potentially offer greater environmental gains better efficiency thermoelectric generators study provides valuable information stake holders interested waste heat recovery technologies gives policymakers perspectives regarding different technological options development cleaner engine solutions elsevier ltd rights reserved
water plays important role human civilisation since ancient times people started settle regions ensured water availability trade important factor development civilisation silk road important route used trading china countries across eurasia silk many goods including leather exchanged trading leather processing lead release large amount wastewater study carried understand leather processing would affected groundwater quality silk road sites studying current scenarios groundwater quality near tanning industries chennai nearby cities ranipet vaniyambadi chosen case studies groundwater quality around tanneries poor due high electrical conductivity concentration chromium due effluents released tanneries ground open drains without proper treatment similarly leather processing silk road sites would also affected groundwater quality
reality monitoring refers processes involved distinguishing internally generated information information presented external world activity thought based part assessment activated features amount type cognitive operations perceptual content impairment reality monitoring implicated symptoms mental illness associated widely occurrence anomalous perceptions well false memories beliefs present experiment cognitive mechanisms reality monitoring probed healthy individuals using task investigated effects stimulus modality auditory visual type action undertaken encoding thought speech subsequent source memory reduced source accuracy auditory stimuli compared visual encoding accompanied thought opposed speech greater rate externalization internalization errors stable across factors interpreted within source monitoring framework johnson hashtroudi lindsay results consistent greater prevalence clinically observed auditory visual reality discrimination failures significance findings discussed light theories hallucinations delusions confabulation author published elsevier ltd open access article license
geographic object based image analysis geobia mostly uses proprietary software interest free open source software foss geobia growing interest stems cost savings also benefits concerning reproducibility collaboration technical challenges hamper practical reproducibility especially multiple software packages required conduct analysis study use containerization package geobia workflow well defined foss environment explore approach using two software stacks perform exemplary analysis detecting destruction buildings temporal images conflict area analysis combines feature extraction techniques segmentation object based analysis detect changes using automatically defined local reference values distinguish disappeared buildings non target structures resulting workflow published foss comprising model data ready use docker image user interface interaction containerized workflow presented solution advances geobia following aspects higher transparency methodology easier reuse adaption workflows better transferability operating systems complete description software environment easy application workflows image analysis experts non experts result promotes reproducibility geobia also practical adoption
purpose purpose study estimate population size men sex men msm kazakhstan hiv testing history methods conducted structured interviews msm four geographically disparate cities city implement four population estimation methods ascertain hiv testing history results approximately men corresponding similar individuals kazakhstan aged msm sample reported taking hiv test far exceeds reported msm surveillance data conclusion hiv testing surveillance kazakhstan underestimated number msm underscores need redress social structural barriers hiv testing disclosure sexual behavior experienced msm kazakhstan recommendations include promoting cultural sensitivity among testing staff quality assurance regular training increasing protection public awareness antidiscrimination policy development
mobile phone communication genre sex advice writing often criticized former unkind latter sexist yet research indicates digitally mediated communication may advantages particularly disinhibition might confer benefits personal expression resisting coercion sexual harassment paper investigates whether consent discussed differently popular online sexting tips articles compared similar set general sex advice articles find general sex tips infrequently address consent offer communication optional practice sexting tips stress importance consent often warn sexters potential harm unwanted sext might cause recipient suggest may due particular affordances mobile phone communication including lack physical proximity asynchronicity reduction unconscious nonverbal communication discourse consent appears popular format may potential serve model broader cultural shift towards normalization explicit communication consent sexual acts
human emotions often expressed facial expressions generated facial muscle movements recent years analysis facial expressions emerged active research area due various applications human computer interaction human behavior understanding biometrics emotion recognition computer graphics driver fatigue detection psychology novel analysis dynamic facial expressions using positional information automatically detected facial landmarks wavelet transformation presented results proposed spatio temporal descriptor descriptor employed within current paper retrieval scheme dynamic facial expression datasets thoroughly evaluated experiments conducted using six prototypical expressions publicly available dfe dataset well eight expressions included newly released publicly available bpd spontaneous dataset obtained retrieval results outperform retrieval results state art methodologies furthermore retrieval results exploited achieve unsupervised dynamic facial expression recognition aforementioned unsupervised procedure achieves better recognition accuracy compared supervised dynamic facial expression recognition state art techniques
aim investigate antioxidant hepatoprotective effects cortex dictamni aqueous extract cdae carbon tetrachloride ccl induced liver damage rats methods vitro antioxidant effect cdae investigated using alpha alpha diphenyl beta picrylhydrazyl dpph azino bis ethylbenzthiazoline sulfonic acid abts beta carotene bleaching reducing power thiobarbituric acid reactive substance assays linoleic acid system including ferric thiocyanate ftc thiobarbituric acid tba assays used evaluate inhibition lipid peroxidation vivo hepatoprotective antioxidant effects cdae ccl induced liver damage evaluated sprague dawley rats silymarin used positive control liver damage assessed determining hepatic histopathology liver marker enzymes serum enzyme non enzyme antioxidant levels lipid peroxide content measured liver cytochrome cype protein expression measured via immunohistochemical staining nuclear factor related factor nrf heme oxygenase nad quinine oxidoreductase nqo gamma glutamylcysteine synthetase catalytic subunit gamma gcsc protein expression measured western blot results results showed cdae exhibited strong antioxidant activity vitro cdae scavenged dpph abts radicals dose dependent manner cdae inhibited lipid peroxidation lipid peroxide inhibition rate ftc tba assays cdae significantly inhibited lipid peroxidation vivo histopathological studies indicated ccl induced liver injury alleviated following cdae treatment rats sexes cdae significantly prevented ccl induced elevations alkaline phosphatase glutamate pyruvate transaminase aspartate aminotransferase total bilirubin levels rats sexes moreover cdae restored decreased activities hepatic antioxidant enzymes including superoxide dismutase catalase glutathione peroxidase well non enzyme antioxidant glutathione induced ccl treatment cdae significantly suppressed regulation cype promoted nrf nqo gamma gcsc protein expression conclusion cdae exhibits good antioxidant performance vitro marked radical scavenging anti lipid peroxidation activities cdae effective preventing ccl induced hepatic damage rats sexes hepatoprotective activity cdae may attributable antioxidant activity may involve keap nrf mediated antioxidant regulation
medium selectivity notch filter proposed active filter one operational amplifier three resistors one floating capacitor passive components two floating resistors provide positive feedback one grounded resistor used independent tuning factor amplifier pole frequency used designing circuit amplifier used positive negative feedback configuration filter tuned wide frequency range khz khz medium factor upto achievable proposed configuration circuit shows low passive parameter sensitivity characteristic single pole model pspice simulations presented verify theoretical analysis
success machine learning algorithms strongly depends feature extraction data representation stages classification estimation small repetitive signals masked relatively large noise usually requires recording processing several different realizations signal interest one main signal processing problems solve estimating classifying evoked potentials brain computer interfaces cope issue propose novel autoencoder variation called coherent averaging estimation autoencoder new multiobjective cost function illustrate use analyze performance problem event related potentials processing experimental results showing advantages proposed approach finally presented elsevier rights reserved
multicast routing meets multiple quality service constraints important supporting multimedia com munications internet things iot existing multicast routing technologies iot mainly focus hoc sensor net working scenarios thus responsive robust enough supporting multimedia applications iot environment order tackle challenging problem multicast routing multimedia communications iot paper pro pose two algorithms establishing multicast routing tree multimedia data transmissions proposed algorithms leverage entropy based process aggregate weights comprehensive metric uses search multicast tree basis spanning tree shortest path tree algorithms conduct theoretical analysis extensive simulations evaluating proposed algorithms analytical experimental results demonstrate one proposed algorithms efficient representative multiconstrained multicast routing algorithm terms speed accuracy thus able support multimedia communications iot environ ment believe results able provide depth insight multicast routing algorithm design multimedia communications iot
remote sensing atmospheric water vapor using global positioning system gps data become effective tool meteorology weather forecasting climate research paper presents estimation precipitable water gps observations meteorological data algeria three stations located algiers bechar tamanrasset objective study analyze sensitivity gps estimates three sites weighted mean temperature obtained separately two types regression one general one developed specifically algeria stands surface temperature calculated directly era interim data results show differences order producing differences final evaluation good agreement found gps calculated radiosondes small mean difference vaisala radiosondes comparison gps era interim shows large difference highlands region difference possibly due topography first results encouraging particular meteorological applications region good hope extend dataset analysis complete nationwide coverage algeria
dampe dark matter particle explorer scientific satellite mainly aimed indirectly searching dark matter space one critical sub detector dampe payload bgo bismuth germanium oxide calorimeter contains pmt photomultiplier tube dynodes fee front end electronics boards vata two channel low power asics application specific integrated circuits adopted key components fees perform charge measurement pmt signals order monitor parameter drift may caused temperature variation aging environmental factors onboard calibration circuit designed vata asics mainly composed bit dac digital analog converter operational amplifier analog switch test results showed dynamic range precision root meam square rms achieved covers input range used compensate temperature drift test trigger function fees calibration circuit implemented front end electronics bgo calorimeter verified environmental tests qualification model flight model dampe dampe satellite launched end calibration circuit operate periodically space
shaken baby syndrome term often used physicians public describe abusive trauma inflicted infants young children advances understanding mechanisms associated clinical spectrum injury lead modify terminology address abusive trauma pediatric abusive head trauma defined injury skull intracranial contents infant young child age due inflicted blunt impact violent shaking chapter focuses imaging aspects childhood abusive trauma along brief description mechanismand pathophysiology abusive injury diagnosis always obvious abusive injuries many infants may remain unrecognized pediatricians cognizant since pediatricians play crucial role diagnosis management prevention
article numerical method detailed studies two phase mass transfer introduced based three dimensional finite volume arbitrary lagrangian eulerian method implementation two phase species equation employs dirichlet neumann algorithm following domain coupling technique underlying hydrodynamical solver tukovic jasak coupling found dependent discontinuities concentration first derivative well side interface dirichlet neumann conditions specified relaxation parameters introduced stabilize algorithm optimal coefficients calculated explicitly numerical method thoroughly validated three dimensional advection diffusion test case proving accuracy local sherwood numbers peclet numbers ten times higher currently reported maximum additionally limit model instantaneous reactions implemented validated allowing computation product concentrations local global enhancement factors elsevier ltd rights reserved
human islet amyloid polypeptide hiapp considered core fibrillating fragment hiapp associated pathogenesis type diabetes mellitus current challenge discovery efficient way modulate amyloid aggregation inhibit toxicity aggregates work photoexcited porphyrins successfully used inhibit fibrillation hiapp insights inhibitory mechanism explored analysis secondary structure morphology mechanical properties amyloid aggregates addition photoexcited porphyrins displayed retained inhibitory effect hiapp aggregation without irradiation findings may establish new avenue inhibit aggregation amyloid peptide hiapp enrich current selection modulators elsevier inc rights reserved
treatment perpetrators tried tested albeit little researched prevention recidivism domestic violence germany study investigated evidence batterer programs risk domestic violence recidivism risk child maltreatment reported fathers perpetrators domestic violence based indicators high risk reassault confirmed international longitudinal studies risk inventory domestic violence developed implemented three german program sites shortened german version child abuse potential inventory interpersonal reactivity index used perpetrators self report study showed child abuse potential program dropouts significantly higher compared program completers baseline longitudinal results showed significant improvements moderate effect sizes risk indicators assessed specialists battered women perpetrators self report cognitive empathy improved however selfreported risk child maltreatment change evidence selective questioning victims found classification results well implications treatment perpetrators research recidivism germany discussed
purpose condylar reconstruction replacement using alloplastic materials currently attracts much surgical interest major challenge functionally reconstruct anatomical region crucial terms correct mandibular function goal present study evaluate clinical outcomes complications experienced series oncological patients underwent computer aided design computer aided manufacturing cad cam condylar reconstruction following resection disarticulation mandible materials methods included nine patients underwent disarticulation resection surgery treat benign malignant mandibular tumors involving condylar region resections preserved articular meniscus featured placement cad cam reconstructive plate supporting fibular microvascular free flap head prosthetic condyle reproduced anatomical morphology native condyle patients clinically evaluated terms occlusion stability mandibular functional recovery static dynamic pain preservation normal mandibular contour planning postoperative computed tomography scans superimposed assess accuracy reconstruction results patient experienced plate exposure direct clinical examination patient complained joint pain patient developed plate loosening resorption glenoid fossa evident pre postoperative bone thicknesses compared preoperative occlusion preserved dentate patients one patient exhibited condylar displacement terms reconstructive accuracy average postoperative deviation condyle preoperative position range conclusions clinical outcomes series oncological patients underwent reconstruction using cad cam plates including condyles encouraging utility protocol needs confirmed larger patient series european association cranio maxillo facial surgery published elsevier ltd rights reserved
objectives studied practice using nurse telephone follow physician direction assess symptom improvement patient satisfaction methods women recruited clinical care merited nurse telephone follow opinion attending physician women specified preferred telephone number completed symptom questionnaire time enrollment nursing telephone follow completed interval prescribed attending physician answer specified clinical questions approximately months initial office visit satisfaction questionnaire repeat symptom measure mailed subjects results convenience sample women analyzed reached telephone returned follow questionnaire mean age years range years younger women less likely able contacted telephone less likely return questionnaire common diagnoses overactive bladder mixed urinary incontinence satisfaction rates high level convenience patients high women indicated ease speaking telephone condition confidence treatment plan satisfaction telephone follow significantly differ based age diagnosis conclusions patient satisfaction high nurse telephone follow replace office visits selected diagnoses care strategy deserves consideration reimbursement purposes health care evolves
paper discusses procedures development experimental investigation solar collector air heating using solar energy concentrator collector consists solar energy concentrator made polished stainless sheets bent according parabola total aperture area focus concentrator heat absorber tube assembled specific form separate aluminium elements wall density painted black tarnished colour placed form absorber elements creating turbulent air flow absorber tube increases heat exchange wall centrifugal ventilator air flow changeable intensity absorber tube created electric motor ventilator fed direct current produced amorphous silicon flexible photovoltaic module sunny september day efficiency collector heated air temperature increment reached degrees air used room heating drying needs
background aim although etiopathogeneses psoriasis atopy appear different psoriasis found associated atopy atopic dermatitis study aimed determine role atopy examining medical history clinical laboratory findings patients psoriasis materials methods patients psoriasis asthma patients healthy volunteers included study serum total immunoglobulin ige levels obtained prick tests administered groups results psoriatic patients demonstrated percentages atopy history higher healthy subjects median total ige level psoriatic patients found statistically higher healthy control group respect mite positivity statistically significant differences psoriatic asthmatic groups compared healthy control group conclusion study first use skin prick tests psoriatic patients skin prick test sensitivity mites increased psoriatic patients believe finding may useful protecting psoriatic patients activation psoriasis determining appropriate treatment approach
impact violent video games vvgs youth remains unclear given inconsistent results past literature previous experimental studies done college students youth current study examined impact vvgs experimental study teens participants randomized play either violent non violent video game teens also reported levels stress hostility video game play hostility levels neither decreased increased following violent game play bayesian analyzes confirmed results supportive null hypothesis contrast vvg exposure increased stress girls impact vvgs teen hostility minimal however players unfamiliar games may find unpleasant results put context uses gratifications theory suggestions medical professionals address issue vvg play concerned parents
backgroundthe metabolic activity colonic microbiota influenced diet however relationship metabolism colonic content known aim determine effect meals defecation diet colonic content methodsin healthy subjects two abdominal mri scans acquired fasting week apart days low high residue diets respectively diet daily fecal output number daytime anal gas evacuations measured first study day second scan acquired hours test meal hours nil ingestion second study day scan also acquired spontaneous bowel movement resultson low residue diet daily fecal volume averaged subjects passed daytime anal gas evacuations third day non gaseous colonic content high residue diet increased three parameters anal gas evacuations fecal output non gaseous colonic content low residue diet low residue diet non gaseous content right colon increased hours test meal whereas significant change observed hour fast fed defecation significantly reduced non gaseous content distal colonic segments conclusion inferencescolonic content exhibits physiologic variations approximate daily turnover produced meals defecation superimposed diet related day day variations
psychopathological symptoms cognitive impairment related psychosocial functioning however nature association cognitive impairment psychosocial functioning still remains scrutiny aimed examine relationships premorbid adjustment lifetime psychopathological dimensions cognitive performance typical level psychosocial functioning previous year assessed ninety patients schizophrenia spectrum disorders affective disorders psychotic symptoms collect data premorbid adjustment lifetime psychopathological dimensions cognitive performance psychosocial functioning sixty five healthy volunteers included controls pearson correlations hierarchical regression analyses performed ascertain extent aforementioned variables predicted psychosocial functioning functional domains significantly correlated premorbid features lifetime psychopathological dimensions cognitive domains however lifetime negative symptoms best predictors psychosocial functioning hierarchical regression analyses explaining variance psychosocial outcome patients psychoses lifetime negative symptoms showed stronger predictive validity cognitive impairment premorbid adjustment elsevier rights reserved
global loss dna methylation frequently observed genome human tumors although epigenetic alteration clearly associated cancer progression way exerts pro tumoral effect remains incompletely understood remarkable consequence dna hypomethylation tumors aberrant activation cancer germline genes also known cancer testis genes comprise diverse group germline specific genes use dna methylation primary mechanism repression normal somatic tissues review evidence cancer germline genes contribute key processes tumor development notably several cancer germline genes found stimulate oncogenic pathways involved cell proliferation ssx ddx mael piwil angiogenesis ddx immortality boris ctcfl metastasis gabra others appear inhibit tumor suppressor pathways including controlling growth inhibition signals magea mageb apoptosis magea magec genome integrity hormad nxf cancer germline genes also implicated regulation tumor metabolism magea magea together survey substantiates concept dna hypomethylation promotes tumorigenesis via transcriptional activation oncogenes importantly considering highly restricted pattern expression cancer germline genes may represent valuable targets development anti cancer therapies limited side effects elsevier rights reserved
boolean networks bns discrete time dynamical systems boolean state variables bns recently attracting considerable interest computational models biological systems particular gene regulating networks boolean control networks bcns boolean networks boolean inputs consider problem steering bcn given state desired state minimal time using algebraic state space representation assr bcns derive several necessary conditions stated form maximum principles mps control time optimal assr every state input vector canonical vector using special structure yields explicit state feedback formula time optimal controls demonstrate theoretical results develop bcn model genetic switch controlling lambda phage development upon infection bacteria results suggest biological switch designed way guarantees minimal time response important environmental signals
major basketball competitions characterized complex rapid attack defense phases mainly involving higher execution speed performing technical procedures well individual collective tactical actions research aims presenting basketball coaches results obtained applying profile nonverbal sensitivity pons nonverbal communication test ambady consider optimization type communication improve game relations among players well athletes coaches implementing game tactics achieving outstanding performance authors published elsevier ltd
background chronic kidney disease ckd end stage kidney disease eskd continue diagnosed major burden aboriginal communities central australia aim study examine risk poor clinical outcomes associated elevated albumin creatinine ratio acr among aboriginal people central australia methods cox proportional hazards models used estimate risk end stage kidney disease eskd dialysis cvd cardiovascular disease mortality associated participants baseline albuminuria reading year cohort study aboriginal people three communities central australia predictors progression albuminuria also examined context kidney health australia kha risk matrix results baseline acr level mmol associated almost fold increased risk eskd fold risk dialysis albuminuria mmol also associated borderline increased risk cvd significant association observed mortality causes chronic disease diabetes waist hip ratio independently predicted two fold increased risk progression higher acr levels conclusions single measure moderately increased albuminuria strong predictor renal failure population single spot urine acr analysis conjunction kha risk matrix may useful efficient strategy screen risk ckd progression dialysis remote communities focus individuals diabetes central obesity strategies avoid increases albuminuria may also prevent future ckd cvd complications
ice flow velocity used estimate ice mass changes glaciers significant indicator stability antarctica ice sheet global change studies existing regional antarctica ice flow speed maps usually derived radar optical satellite observations modern satellites since paper presents new analytical photogrammetric method estimating antarctica ice flow velocity fields using film based stereo argon photographs collected key proposed innovative method parallax decomposition separates effect terrain relief ice flow motion innovative implementation strategy developed using framework involves key techniques hierarchical stereo image matching ice flow direction determination parallax decomposition ice flow speed estimation method applied rayner glacier eastern antarctica using two sets argon images two month interval produced digital terrain model speed map achieved ground position accuracy speed accuracy comparison recent products shows significant topographic changes study area furthermore speed around grounding line remained level speed ice shelf front decreased ice shelf front advanced approximately years overall observation results indicate favorable conditions stability rayner glacier ice shelf system
callous unemotional traits designate important subgroup antisocial individuals risk early starting severe persistent conduct problems construct received limited attention among young children current study evaluated factor structure psychometric properties validity scores comprehensive measure traits inventory callous unemotional traits icu relation measures antisocial prosocial behavior emotional processing administered preschool children sample included boys girls age recruited mainstream high risk preschools confirmatory factor analyses supported two factor structure including callous uncaring dimensions original icu items scores parent teacher reported icu internally consistent combined scores showed expected associations alternate measure traits measures empathy prosocial behavior conduct problems aggression preschool children high traits less accurate relative children scoring low recognizing facial expressions also less attentionally engaged images others distress occurring conduct problems presented findings extend literature supporting psychometric properties icu among young children open several avenues studying early precursors severe personality disturbance
aims investigate pain sensitivity using quantitative sensory testing older women without cervicogenic headache methods total older women mean age standard deviation years cervicogenic headache healthy controls years participated study pain thresholds pressure heat cold suprathreshold heat pain ratings degrees degrees degrees measured temporalis muscle upper cervical spine tibialis anterior muscle analysis variance used determine differences pain outcomes groups results compared control group cold pain threshold cervicogenic headache patients significantly decreased upper cervical region temporalis tibialis anterior muscles significant group differences pressure pain threshold heat pain threshold suprathreshold heat pain ratings sites conclusion older women cervicogenic headache localized pain sensitivity cold stimuli suggesting peripheral mechanisms underlie hyperalgesia
recent methods detailed accurate biomass carbon stock estimation forests driven advances remote sensing technology conventional approach biomass estimation heavily relies tree species site specific allometric equations based destructive methods paper introduces non destructive laser based approach terrestrial laser scanner individual tree aboveground biomass estimation royal belum forest reserve perak malaysia study area state park believed one oldest rainforests world point clouds generated forest plots using terrestrial laser scanner geo rectified cleaned produce separate point clouds individual trees volumes tree trunks estimated based cylinder model fitted point clouds biomasses tree trunks calculated multiplying volume species wood density biomasses branches leaves also estimated based estimated volume density values branch leaf volumes estimated based fitted point clouds using alpha shape approach estimated individual biomass total ground biomass compared aboveground biomass agb value estimated using existing allometric equations individual tree census data collected field results show combination simple single tree stem reconstruction wood density used estimate stem biomass comparable results usually obtained existing allometric equations however several issues associated data method used branch leaf biomass estimations need improvement
development non human primate nhp model spinal cord injury sci based mechanical computational modeling described scaled rodent model larger primate model using highly controllable friction free electronically driven actuator generate unilateral spinal cord injuries graded contusion lesions varying degrees functional recovery depending upon pre set impact parameters produced nine nhps protocols pre operative magnetic resonance imaging mri used optimize predictability outcomes matching impact protocols size animal spinal canal cord cerebrospinal fluid space post operative mri confirmed lesion placement provided information lesion volume spread comparison histological measures evaluated relationships impact parameters lesion measures behavioral outcomes confirmed relationships consistent previous studies rat addition providing multiple univariate outcome measures also developed integrated outcome metric describing multivariate cervical sci syndrome impacts higher ranges peak force produced highly lateralized enduring deficits multiple measures forelimb hand function lower energy impacts produced early weakness followed substantial recovery enduring deficits fine digital control pincer grasp model provides clinically relevant system evaluate safety potentially efficacy candidate translational therapies
article highlights social work critical thinking ethic care geriatric teamwork promote generativity well latinx elderly offer tripartite paradigm cultural humility transformative complicity empowerment reduce power imbalances service providers elderly persons communities force field analysis considers patient protection affordable care act ppac accountable care organizations aco understand restraining driving forces affecting institutionalization inter transdisciplinary teams effective evidence based models humanize geriatric services offered counter current biomedical emphasis medicare medicaid policies less responsive geriatric institutional educational systems highlight bloom farragher sanctuary model compassionate democratic practices address negative effects moral entrepreneurship ageism case florence lgbtq lesbian gay bisexual trans questioning grandparent multiple health issues analyzed biomedical person environment strength based perspective
courses computer programming language important basic specialty courses majors science technology universities courses often highly abstract practical many works involved teaching process worth exploring researching focusing teaching methods programming language course paper presents ideas practice performing teaching work course paper discusses important works different teaching links including textbook selection courseware preparation classroom teaching practical ability training practice proved adopting appropriate teaching methods adapt actual situation teaching process teachers control teaching process flexibly improve teaching effectiveness quality
provision high quality urban water services assets often conceptualised blue infrastructure essential public health quality life cities hand parks recreation grounds gardens green roofs general green infrastructure provide range urban ecosystem services including quality life aesthetics could also thought inter alia contributors mitigation floods droughts noise air pollution urban heat island uhi effects improvement biodiversity amenity values human health currently blue green assets infrastructure planned operate two separate systems despite obvious interactions example low runoff coefficient green areas resulting reduction stormwater flows irrigation green areas potable water increasing pressure water supply systems study explores prospects integrated blue green approach tested scale household specifically uwot urban water optioneering tool extended used assess potential benefits scheme employed locally treated greywater along harvested rainwater irrigating green roof results simulations indicated blue green approach combined benefits green blue technologies services time minimised disadvantages installed separately
groundwater plays important role socioeconomic development comoro watershed timor leste despite significance groundwater sustainable development always properly managed watershed therefore study seeks identify groundwater potential zones comoro watershed using geographical information systems remote sensing analytic hierarchy process technique groundwater potential zones thus obtained divided five classes validated recorded bore well yield data found alluvial plain northwest along comoro river high groundwater potential zone covers area watershed high groundwater potential zone found eastern part along foothills covers area moderate zone covers area found higher elevation alluvial plain poor poor groundwater potential zone covers watershed hilly terrain located southern central parts study area poor groundwater potential zone due higher degree slope low permeability conglomerate soil type demarcation groundwater potential zones comoro watershed helpful future planning development management groundwater resources
oral vitamin anticoagulation warfarin coumadin coumarin long used long term treatment prophylaxis variety clinical settings given unpredictable pharmacokinetic food impact warfarin episodic monitoring required since early direct oral anticoagulants doacs entered clinical trials potential alternative strategy oral vitamin antagonists long term anticoagulation drugs predictable pharmacokinetics pharmacodynamics requirement episodic routine monitoring however shortly introduction clinical use became apparent certain emergent acute situations may require capacity measure drugs especially bleeding patient doac exposure scramble literature data support suggest laboratory methods rapidly accurately quantify estimate doac concentration soon began review describes literature date recommendations laboratories provide tests assure either presence absence doac capacity quantify doac using rapid methods could implemented clinical laboratory instruments
article presents basic concepts recent research directions stability sampled data systems aperiodic sampling focus mainly stability problem systems arbitrary time varying sampling intervals addressed several areas research control theory systems aperiodic sampling seen time delay systems hybrid systems input output interconnections discrete time systems time varying parameters etc goal article provide structural overview progress made stability analysis problem without exhaustive would neither possible useful try bring together results diverse communities present unified manner existing approaches basic concepts fundamental results converse stability theorems available relations approaches discussed detail results concerning extensions lyapunov frequency domain methods systems aperiodic sampling recalled allow derive constructive stability conditions furthermore numerical criteria presented indicating sources conservatism problems remain open possible directions improvement last emerging research directions design stabilizing sampling sequences briefly discussed elsevier ltd rights reserved
epstein barr virus ebv infection associated cell lymphomas humans ability ebv convert human cells long lived lymphoblastoid cell lines lcls vitro requires collaborative effects ebna hijacks notch signaling latent membrane protein lmp mimics signaling ebv encoded nuclear antigen ebnaa ebnac inhibit oncogene induced senescence apoptosis however recently showed lmp deleted ebv mutant induces cell lymphomas newly developed cord blood humanized mouse model allows ebv infected cells interact cells major source ligand examined whether ebv lmpa protein mimics constitutively active cell receptor signaling required ebv induced lymphomas model find deletion lmpa delays onset ebv induced lymphomas affect tumor phenotype number tumors simultaneous deletion lmp lmpa results fewer tumors delay tumor onset nevertheless lmp lmpa double mutant induces lymphomas approximately half infected animals results indicate neither lmp lmpa absolutely essential ability ebv induce cell lymphomas cord blood humanized mouse model although simultaneous loss lmp lmpa decreases proportion animals developing tumors increases time tumor onset thus expression either lmp lmpa may sufficient promote early onset ebv induced tumors model importance ebv causes human lymphomas models available dissecting ebv causes lymphomas vivo context host immune response recently used newly developed cord blood humanized mouse model show ebv cooperate human cells cause cell lymphomas even major viral transforming protein lmp deleted examined whether ebv protein lmpa mimics cell receptor signaling required ebv induced lymphomas model find deletion lmpa alone little effect ability ebv cause lymphomas delays tumor onset deletion lmp lmpa results smaller number lymphomas infected animals even delayed time tumor onset results suggest lmp lmpa collaborate promote early onset lymphomas model neither protein absolutely essential
paper presents distributed approach scales segment tree crowns within lidar point cloud representing arbitrarily large forested area approach uses single processor tree segmentation algorithm building block order process data delivered shape tiles parallel distributed processing performed master slave manner master maintains global map tiles coordinates slaves segment tree crowns within across boundaries tiles minimal bias introduced number detected trees trees lying across tile boundaries quantified adjusted theoretical experimental analyses runtime approach revealed near linear speedup estimated number trees categorized crown class associated error margins well height distribution detected trees aligned well field estimations verifying distributed approach works correctly approach enables providing information individual tree locations point cloud segments forest level area timely manner used create detailed remotely sensed forest inventories although approach presented tree segmentation within lidar point clouds idea also generalized scale processing big spatial datasets
visual elements central components current political communication visual portrayals example convey cues attributes affect perceived credibility truthfulness suitability politicians pervasive use images politics made visual political communication important research area yet analyses field predominantly use content analyses examine valence visual portrayals present study investigates audience actually interprets visual cues composition elements images politicians compares results findings content analyses card sorting technique sort qualitative interviews employed capture subjective intuitive interpretations color photographs politician compared attribute measurements previous content analyses results show strong accordance audience interpretation attribute analysis regarding unfavorable political depiction however findings indicate disagreement composition favorable depiction
growing main memory capacity fueled development memory big data management processing eliminating disk bottleneck possible support interactive data analytics however memory systems much sensitive sources overhead matter traditional bounded disk based systems issues fault tolerance consistency also challenging handle memory environment witnessing revolution design database systems exploits main memory data storage layer many researches focused along several dimensions modern cpu memory hierarchy utilization time space efficiency parallelism concurrency control survey aim provide thorough review wide range memory data management processing proposals systems including data storage systems data processing frameworks also give comprehensive presentation important technology memory management key factors need considered order achieve efficient memory data management processing
national partner countries international trade manufacturing engineering engineering technology advances different degrees impact paper analyzes development china manufacturing variations export trade theory explain import export trade tfp impact mechanism finally industry grouping according manufacturing industry technical standards industry size compared regression results grouped reasons differences empirical analysis based main conclusions drawn papers put forward relevant policy recommendations
morbidity mortality bradykinin mediated angioedema considerable upper respiratory tract involved associated emergency treatment admission intensive care department laryngeal oedema macroglossia common patients presenting effect taking converting enzyme inhibitors ace inhibitors hereditary forms abdominal pain common involvement larynx progressive nature oedema risk factors admission hospital attack following reaction ace inhibitors emergency specific treatments primarily include inhibitor concentrate icatibant must administered early possible given anti allergy treatments ineffective specialist advice including emergency department appears required appropriate care patients treatment patients recently changed development links doctors specialising emergency medicine referring physicians bradykinin mediated angioedema reference centre appropriate treatment pathway multidisciplinary management vital providing correct care patients view ensuring emergency specific treatments available
video monitoring system due complicated background environment light changes restrictions performance device resulting difficulty target detection algorithm design traditional target detection algorithms typically rely manual selection features hard get valid classification amounts data based deep learning algorithm paper constructs convolutional neural network using person vehicle graphics collected bionic eye monitoring system training network besides design series experiments analysis characteristics network proved training set distribution samples category number training samples small case would impact results training deep learning network addition shows parameters model using fuzzy image training get similar result fuzzy image clear image
effective temperature control vehicle climate chamber investigated temperature regulated electrical heater power valve opening chilled water system cooling load water flow rate adjusting valve studied based distributed parameter model developed previous article order ensure flow capacity increase linearity cooling side control output air temperature two equal percentage valves applied climate chamber characteristics large thermal inertia non linearity performance propor tional integral derivative pid controller used existing system satisfactory fuzzy self tuning pid controller designed pid gains tuned online according temperature error error change rate air velocity using fuzzy logic model predictions showed fuzzy pid control stabilized air temperature shorter time smaller overshoot undershoot time averaged temperature error reduced degrees degrees high temperature test low temperature test reduced degrees degrees elsevier ltd rights reserved
background syndrome common human genetic disorder caused trisomy chromosome individuals syndrome present range health issues lives may require imaging diagnosis radiographers therefore play significant role management communication syndrome patients health purpose review identified patient centered strategies radiographers use provide quality imaging services syndrome patients may limited verbal ability behavioral issues method systematic review using established prisma guidelines undertaken current literature obtained ovid scopus databases total articles found categorized analyzed detail findings high level care syndrome patients require longer usual procedures patients respond well rushed ignored syndrome patients difficulty verbalizing yet understand often thought individuals may require increased imaging time give time respond especially pain patients risk injury aai pathologies caution taken flexion extension spine rays radiographs may reveal undisclosed physical abuse conclusion specific strategies verbal nonverbal communication help facilitate communication reduce anxiety fear improve compliance syndrome patients patients may require increased level care increased imaging time allowing support people present examination process
objectives wealth studies provide evidence action simulation language comprehension recent research suggests action simulations might sensitive fine grained information speed present crucial test action simulation speed language assessing speed comprehension patients parkinson disease based patients motor deficits hypothesized speed motion described language would modulate performance semantic tasks specifically would difficulty processing language relatively fast speed language slow speed methods conducted semantic similarity judgment task fast slow action verbs patients age matched healthy controls participants decide two verbs closely matched target word results compared controls patients slower making judgments fast action verbs judgments slow action verbs suggesting impairment processing language fast action moreover impairment specific verbs describing fast action performed hand conclusions problems moving quickly lead difficulties comprehending language moving quickly study provides evidence speed important part action representations
introduction achieving adherence medications serious challenge patients affected inflammatory bowel disease ibd medical treatment fundamental inducing maintaining remission preventing flares reducing risk colorectal cancer non adherence may affect patients quality life resulting unfavourable treatment outcomes hospitalizations higher healthcare related costs recognising improving adherence therefore primary aim treatment ibd areas covered critically discuss current knowledge medication non adherence adult patients affected ibd also mentioning issues concerning paediatric adolescent populations particular reviewed literature focusing definition detection non adherence extent possible non modifiable modifiable factors involved patient centred therapy related disease related physician related furthermore analysed interventional studies performed far literature review conducted pubmed addressing medication non adherence ibd using keywords adherence related terms ibd ulcerative colitis crohn disease expert commentary adherence therapy ibd complex yet fundamental issue solved addressing single aspect future studies focus patient tailored multidimensional interventions
background rheumatoid arthritis psoriatic arthritis psa result severe joint destruction functional disability left untreated aim develop tools help patients psa understand experience impact inflammatory joint disease integrity juxta articular bone increase adherence medical treatment study used high resolution peripheral quantitative computed tomography pqct develop prototypes patients finger joints methods pqct xtremect scanco measurements performed healthy individuals patients inflammatory joint disease followed print using objet printer healthy participants patients psa underwent detailed standardized interview demonstration printed joints results utilizing pqct images metacarpophalangeal mcp heads high quality exact prints prototypes created erosions different sizes trabecular network printed detail visualized demonstrating structural reduction arthritic healthy bone demonstration prints healthy erosive joint visual haptic participants including healthy volunteers deeply affected often quoting shock patients psa respectively stated would rethink attitude medication adherence importantly patients psa expressed would wished see prints first disease specific conversations conclusion using arthro haptic printed prototypes joints may help better understand impact inflammatory arthritides bone integrity long term damage
background aims one knows exactly proportion gallstones cause clinical events among subjects unaware gallstone status investigated long term occurrence clinical events gallstones associations ultrasound observations clinical events methods analyzed data randomly selected groups general population urban copenhagen age participating international study cardiovascular risk factors multinational monitoring trends determinants cardiovascular disease study study participants examined underwent abdominal ultrasound examinations detect gallstones study population comprised subjects gallstones subjects informed gallstone status participants followed clinical events central registers december independent variables included ultrasound characteristics age sex comorbidity female associated factors analyzed using cox regression results study participants followed median years range participants completed study total participants developed events complicated uncomplicated ten percent awareness gallstones awareness associated uncomplicated complicated events stones larger associated events hazard ratio confidence interval acute cholecystitis uncomplicated events including cholecystectomy multiple stones associated events complicated events common bile duct stones association gallstones years old acute cholecystitis female sex associated uncomplicated events found negative association participant age events uncomplicated events acute cholecystitis comorbidities female associated factors intake birth control pills estrogens number births associated events compared men single stone smaller reference women multiple stones greater highest risk events unadjusted absolute risk events person years conclusions fewer subjects gallstones develop clinical events larger multiple older gallstones associated events studies needed confirm prediction rules
novel longer lasting inflammatory bladder animal models needed better understand pathophysiology chronic cystitis previously developed relatively long lasting mouse cystitis model intravesical injection hydrogen peroxide evaluate pathophysiology study established analyzed rat cystitis model anesthesia solution introduced transurethrally bladder female rats kept min injection significantly increased number micturition events day decreased urine volume per micturition smallest volumes day compared vehicle treated group cystometric analysis day revealed intercontraction intervals significantly shortened without affecting baseline threshold maximum pressures intravesical resiniferatoxin evoked nociceptive behaviors freezing significantly enhanced days furthermore histopathology revealed hemorrhage edema infiltration neutrophils lamina propria urothelial denudation early phase day damages gradually repaired hyperplasia urothelium vascularization increases fibroblast counts infiltration mast cells eosinophils observed later phase days results suggest intravesical injection induces relatively long lasting cystitis enhanced bladder activity pain sensation rats approach thus provides novel rat long lasting cystitis model allows analyze detailed symptoms pathophysiology induced cystitis model mouse model may used investigate pathophysiology treatment chronic bladder hypersensitive disorders bladder pain syndrome interstitial cystitis
low endogenous testosterone production known hypogonadism commonly associated conditions inducing muscle wasting akt signaling control skeletal muscle mass mtor regulation protein synthesis foxo regulation protein degradation pathway previously identified target androgen signaling however testosterone sensitivity akt mtor signaling requires understanding order grasp significance varied testosterone levels seen wasting disease muscle protein turnover regulation therefore purpose study determine effect androgen availability muscle akt mtorc foxoa regulation skeletal muscle cultured myotubes cbl mice either castrated days castrated treated nandrolone decanoate testosterone loss significantly decreased volitional grip strength body weight gastrocnemius gas muscle mass reversed changes related muscle mass regulation decreased muscle igf mrna rate myofibrillar protein synthesis akt phosphorylation phosphorylation akt targets gsk beta pras foxoa induced expression foxo transcriptional targets murf atrogin redd muscle ampk raptor phosphorylation mtor inhibitors altered low testosterone restored igf expression akt mtorc signaling repressing expression foxo transcriptional targets testosterone sensitivity akt mtorc signaling examined myotubes mtor phosphorylation induced independent akt activation low concentrations higher concentration required activate akt signaling interestingly low concentration sufficient amplify myotube mtor akt signaling withdrawal demonstrating potential cultured myotubes initiated positive feedback mechanism amplify akt mtor signaling summary androgen withdrawal decreases muscle myofibrillar protein synthesis akt mtorc signaling independent ampk activation readily reversible anabolic steroid administration acute akt activation myotubes sensitive high concentration testosterone low concentrations testosterone activate mtor signaling independent akt elsevier ireland ltd rights reserved
objectivesthe mini bestest consists items relevant balance deficiencies among people parkinson disease pwpd however mini bestest construct validity sparsely evaluated population therefore aimed investigate hypotheses mini bestest results would worse among pwpd compared healthy controls pwpd moderate compared mild motor severity iii pwpd history recurrent compared non recurrent falls moreover relationship mini bestest tests similar different constructs expected moderate strong poor respectively materials methodsone hundred five pwpd mild moderate motor severity healthy controls included pwpd divided subgroups based motor severity fall history main outcome measures mini bestest timed tug original unified parkinson disease rating scale part activities daily living independent tests spearman rho used analyses resultsthe mini bestest results worse among pwpd compared controls among people moderate motor severity compared mild severity however differences found recurrent non recurrent fallers spearman rho showed moderate poor correlations convergent tug divergent validity updrs part respectively conclusionsoverall mini bestest appears adequately measure dynamic balance among pwpd mild moderate severity although unable distinguish recurrent non recurrent fallers
electric power generated photovoltaic module greatly reduced compared optimal production due weather conditions factors partial shade main defect conventional maximum power point tracking control algorithm misinterpretation location maximum power point sudden change climatic conditions existence several local maxima power voltage characteristic curve work presents preliminary study modeling simulation implementation new algorithm power output maximization photovoltaic generators partially shaded conditions using bond graph approach idea use buck boost converter test experimentally performance proposed algorithm real photovoltaic panel imposed ten patterns irradiance photovoltaic panel half patterns partial shading proposed controller performed excellently shading conditions compared classical direct duty cycle technique control part proposed algorithm implemented microcontroller efficiency developed algorithm demonstrated function real position maximum power point results simulation performed using symbols system modeling bond graph language simulation software results obtained simulation compared experimental results obtained real measurements using photowatt photovoltaic panel operating conditions climatic environment
introduction large body literature highlighted women household decision making power associated better reproductive health outcomes studies tend measure power women point view using husband wife matched responses decision making questions study examined association couples concordant discordant decision makings wife unmet need contraception bangladesh methods study used couple data set bangladesh demographic health survey multivariate logistic regression used examine likelihood unmet need contraception among married women reproductive age findings study results suggested couples support equalitarian power structure seemed powerful meeting unmet demand contraception logistic regression analysis revealed compared couple concordant joint decision making concordance husband involvement decision making associated higher odds unmet need contraception wives exposed family planning information discussed family planning often husbands richest households less likely unmet need contraception conclusion couple concordant joint decision making reflecting concept equalitarian power structure appeared significant analytic category policy makers field family planning may promote community based outreach programs communication campaigns family planning focusing egalitarian gender roles household elsevier inc rights reserved
purpose review rapid development remote sensing technology hasmade dense data available airborne laser scanning recently also photogrammetric point clouds paper reviews methods extraction individual trees data applications forestry ecology recent findings methods analysis data tree level developed since turn century first algorithms based surface models upper contours tree crowns methods robust provide information trees top canopy also methods use complete data however development methods still needed include use geometric properties detect large fraction tallest trees surface model method generally gives best results detection smaller trees top canopy requires methods utilizing whole point cloud several new sensors available capability describe upper part canopy used frequently update vegetation maps highly sensitive laser photo detectors become available civilian applications enable acquisition high resolution laser data large areas much lower costs summary methods itc delineation data provide information large fraction trees still challenge make optimal use information whole point cloud newly developed sensors might make itc methods cheaper feasible large areas
objectives hypothesisto demonstrate racial differences preventable risk behaviors practices contribute head neck cancer hnca study designcross sectional analysis large national risk factor survey methodsthe behavioral risk factor surveillance system analyzed demographic data extracted including age sex race social habits considered risk factors hnca also extracted including alcohol consumption smoking human papillomavirus hpv vaccination status statistical comparisons conducted according race risk factor additional comparisons conducted within american indian population subgroup risk factors according sex resultsa total million americans surveyed american indians reported higher rates binge drinking whites blacks asian americans rate significantly higher american indian males versus females mean total drinks per month higher whites american indians american indians reported highest rates current smoking followed blacks whites asians american indians also reported highest rates every day smoking versus whites blacks asians rates hpv vaccination lowest american indians compared whites blacks asians conclusionsthere striking racial disparities prevalence preventable risk factors hnca data highlight need targeted education prevention programs particular racial groups level evidence laryngoscope
nowadays quickest developing rate among kinds renewable energy generation belongs wind power industry hence proposing optimization framework achieve best design wind power conversion system especially wind electrical generator required ever recently flux switching permanent magnet fspm generators well known rigid structure high torque density lower weight attracted high attention features bring ability respect permanent magnet synchronous pms generator paper thorough analysis carried find optimal design fspm generator interrogating possibility employ different structures small scale wind conversion systems achieve purpose precise challenge laid investigation various design characteristics hence multiobjective function depending mass cost volume electromagnetic performance generator taken account sequel considering multi attribute decision making madm techniques framework based improved analytical hierarchy process ahp composed hybrid scheme formed artificial neural network ann classical ahp proposed achieve trade design fspm numerical study implemented different test cases assess performance proposed framework obtained results prove goodness proposed technique suggest interesting solutions considered applications
cable conduit conductor cicc cooled forced circulation supercritical helium heat exchange bundle region play significant role conductor safe operation remaining quite uncertain parameter heat exchange bundle jacket depends relative contributions convective heat transfer due helium flow inside bundle thermal resistance due wrappings cable conduit order qualify thermal coupling realistic operating conditions dedicated experiment sample iter toroidal field dummy conductor designed performed helios test facility cea grenoble several methods envisaged choice made assess bundle jacket heat transfer coefficient measuring temperature solid copper cylinder inserted conductor jacket submitted heat deposition outer surface mock manufactured tested spring bundle jacket heat transfer coefficient found range results analysis suggests order magnitude convective heat transfer coefficient inside bundle closer colburn reynolds analogy dittus boelter correlation bundle jacket thermal coupling mainly limited thermal resistance due wrappings model based equivalent layer stagnant helium wraps jacket proposed showed good consistency experiment relevant values helium layer thickness elsevier ltd rights reserved
pectin degrading enzymes essential quality product cocoa fermentation previously studied purified pectate lyases pel produced bacillus strains fermenting cocoa characterized cloned pel genes study aims search biological signals modulates pel production regulators influence pel gene expression strains grown end exponential phase media containing various carbon sources pel enzymes production bacillus unaffected simple sugar content variation additionally appeared pel gene control common carbon pectin catabolism regulators ccpa kdgr could explain insensitivity pel production carbon source variation however fold decrease pel production observed bacteria grown rich medium opposed basal mineral medium subsequently bioinformatics analysis cloned pel gene promoter region revealed presence degu binding site furthermore deletion degu gene dramatically reduces pel gene expression revealed real time quantitative pcr showing activation effect degu pel synthesis bacillus strains studied assumed latter stage cocoa fermentation simple sugars depleted production pel bacillus stimulated degu supply microbial cells carbon source polymeric pectic compounds elsevier ltd rights reserved
switched reluctance motor srm promising drive solution electric vehicle propulsion thanks simple rugged structure satisfying performance low price among srms axial flux srm afsrm strong candidate wheel drive applications high torque power density compact disc shape paper four phase stator pole rotor pole double rotor afsrm investigated bike application series analyses conducted reduce torque ripple shaping rotor poles multi level air gap geometry designed specific air gap dimensions different positions static dynamic analyses show significant torque ripple reduction maintaining average electromagnetic output torque demanded level
study investigates application sliding mode controller smc induction motor drive variable displacement pressure compensated pump vdpc system powered isolated wind storage unit variable speed wind turbine proposed drive permanent magnet synchronous generator pmsg feeds storing energy unit stand alone dynamic load energy storage systems required power balance quality isolated wind power systems initially holistic model entire system achieved including pmsg uncontrolled rectifier buck converter storage system induction machine vdpc pump power absorbed connected loads effectively delivered supplied proposed energy storage systems subject sliding mode control main purposes supply three phase inverter adjust speed vdpc pump flow rate performance proposed system compared neural network control conventional pid control simulation results show proposed system smc neural network controllers good performance good prediction electrical parameter waveforms compared case conventional pid controller
several genetic polymorphisms implicated affect outcome allogeneic hematopoietic stem cell transplantation allo hsct role cytokines acute graft versus host disease agvhd well established many involved cytokines signal janus kinase jak pathways study assessed association recipient donor jak haplotypes allo hsct outcome cohort acute myeloid leukemia patients recipient donor haplotypes significantly affected agvhd grades development respectively furthermore influence haplotypes seemed additive multivariate analyses recipient haplotype remained independently related agvhd donor observed significantly less relapses among haplotype carriers overall survival differ findings suggest recipient donor jak haplotypes might involved regulation agvhd
study aims analyze possible relationships emotional intelligence nonverbal communication sample psychology students completed teique emotional intelligence questionnaire resulting scores used divide sample three groups based mean plus minus one standard deviation analyze differences extreme groups two extreme groups individually recorded performing activity three minute clips recording used expert judges rate nonverbal communication participant correlation student test differences means confirm higher emotional intelligence better nonverbal communication interesting results also presented
withdrawn depressed behavior defined child behavior checklist cbcl relates various outcomes developmental psychopathology depression pervasive developmental disorders suicide sought examine temperamental characteristics children concurrently endorse symptoms junior temperament characteristic inventory jtci cbcl data collected children parents family study northeastern united states linear mixed models used test relations temperament dimensions novelty seeking harm avoidance reward dependence persistence jtci controlling age sex item overlap occurring aggression attention problems controlling definitional artifact cbcl aggressive behavior attention scores high harm avoidance low reward dependence significant predictors childhood withdrawn behavior study marks first characterization temperamental profile associated children adolescents
established primary prevention strategies cardiovascular diseases based understanding risk factors whether risk factors associated atrial fibrillation remains unclear conducted systematic review field synopsis associations cardiovascular risk factors incident included reports based consented four electronic health record cohorts participants events identified reports per risk factor heterogeneity definition quality reporting adjustment extracted relative risks confidence intervals visualised number reports inverse associations hypertension reports obesity reports direct associations incident coronary heart disease chd inverse associations non white ethnicity reports total cholesterol reports reports non significant inverse associations diastolic blood pressure reports reports non significant inverse associations direct associations taller height reports opposite direction known associations chd systematic evaluation available evidence suggests similarities well important differences risk factors incidence compared cardiovascular diseases implications primary prevention strategies atrial fibrillation
development personal care formulations incorporates deliberation prerequisite product rheology right rheology modifier deliver effects effectiveness finished product hinge selection level active ingredients excipients esthetics even penetration actives stratum corneum affected product rheology rheology modifiers frequently denoted thickeners increasing apparent viscosity enhance perception quality formulation one aspect rheological control product newtonian pseudoplastic thixotropic existing ringing gel stringy flowable liquid changes way product appears bottle ease aliquots poured scooped packaging process rubbing skin along hair shaft upon using rinsing removal product also vital select correct rheological characteristics guarantee stability finished formulation changing structure polymeric rheology modifiers impact sensorial properties performance characteristics investigated careful selection monomers structure ingredients result products optimized use skin care formulations copyright john wiley sons ltd
objective relaxin pleiotropic hormone insulin like peptide hormone family plays important role reproductive physiology well fibrosis angiogenesis bone remodelling binds relaxin family peptide receptors rxfp rxfp addition independently bind activate glucocorticoid receptor nrc despite wide ranging effect relaxin expression patterns rxfp facial development examined study aimed identify mrna expression patterns rxfp rxfp nrc oral tissues late mouse facial development order pinpoint structures could sensitive relaxin signalling period design rxfp rxfp nrc mrnas identified situ hybridization using digoxigenin labelled riboprobes coronal sections mouse heads embryonic days results found rxfp rxfp nrc mrnas expressed developing maxilla mandible meckel cartilage tongue tooth primordia embryonic days conclusions receptors bind relaxin present developing oral tissues mice finding suggests relaxin may involved prenatal development face elsevier ltd rights reserved
paper training mode professional master aeronautics astronautics manufacturing engineering relatively advanced domestic colleges hit researched position objective curriculum system practical ability education methods aeronautics astronautics manufacturing engineering degree oriented aerospace clarified better basis master degree training aeronautics astronautics manufacturing engineering provided county aerospace industry
extend recently proposed depth integrated finite volume solver nonlinear shallow water equations non hydrostatic pressure distribution proposed model aimed simulating nonlinear dispersive shallow water processes split total pressure hydrostatic dynamic components solve hydrostatic problem non hydrostatic problem sequentially framework fractional time step procedure dispersive properties achieved incorporating non hydrostatic pressure component governing equations governing equations depth integrated continuity equation depth integrated momentum equations along directions unlike previous non hydrostatic shallow water solver momentum equation retain vertical local convective acceleration terms former solver keep local vertical acceleration term paper investigate effects convective terms possible improvements computed solution terms neglected governing equations especially strongly nonlinear processes presence convective terms vertical momentum equation leads numerical solution procedure quite different one previous solver hydrostatic dynamic steps discretize spatial domain using unstructured triangular meshes satisfying generalized delaunay property numerical solver shock capturing easily addresses wetting drying problems without additional equation solve wet dry interfaces present several numerical applications challenging flooding processes encountered practical aspects irregular topography including new set experiments carried hydraulics laboratory university palermo elsevier ltd rights reserved
novel output subspace identification method proposed estimate structural parameters shear beam building unknown ground excitation unique feature method structural parameters ground acceleration identified using absolute acceleration response displacement velocity responses required method uses two subspace identification techniques sequentially iteratively first technique extracts modal parameters building natural frequencies damping ratios mode shapes using absolute acceleration response assumed identified ground acceleration modal parameters lead estimation building structural parameters mass properties building known second technique estimates ground acceleration using absolute acceleration obtained structural parameters first technique two techniques performed iteratively estimated structural parameters converge numerical example laboratory test used illustrate proposed identification method results show estimation structural parameters fairly robust presence measurement noise unknown ground acceleration high frequency range factors influencing performance technique also studied discussed
article sets explore extent moral dimension essential component organizational life theoretical viewpoint argues institutional theory lacks positive account role morality organizational level propose addressed integrating work moral philosopher alasdair macintyre institutional theory notions logics contradictions legitimacy empirically look group christian churches northeast england provide insights practitioners concerns telos organizations core practices faith hence essential concern morality organizational life conclude understanding practice based organizations ignores underplays moral dimension give best diminished account organizational life hence institutional theory needs rethink neglect morality
optical projection lithography workhorse integrate circuit manufacturing industry transfer computer aided design cad semiconducting material wafers resolution limit wavelength lithography initially targeted design rule extended realise approximate devices ingenious interventions three dimensional fin shaped field effect transistor device structure realise design rule still using projection lithography widely accepted solution extreme ultraviolet wavelength source systems still development testing phases recent success reported still falling short supporting volume production requirements study reviews current trends lithography associated resolution enhancement techniques brief introduction integrated cad analysis hotspot detection
paper presents edge boosting method output buffer using signal front detection digital control circuit presented architecture detects data clock signal transitions activates additional drive strength fingers output buffer resulting output current increase improves slew rate compensating losses transmission lines presented edge boosting method used circuits standards ddr double data rate usb universal serial bus pci peripheral component interconnect etc
comparative study different models identification techniques applied quantification valve stiction industrial control loops presented paper objective taking account presence external disturbances hammerstein system used model controlled process linear block sticky valve nonlinear block five different candidates linear block two different candidates nonlinear block evaluated compared two five linear models include nonstationary disturbance term estimated along input output model extended models meant cope situations significant nonzero mean disturbances affect collected data comparison different models identification methods carried thoroughly three steps simulation application pilot plant data application industrial loops first two cases simulation pilot plant specific source fault stiction without external disturbances known hence validation candidate carried easily nonetheless fault case considered previous two steps found application large number datasets collected industrial loops hence merits limitations candidate confirmed result study extended models proved effective large time varying disturbances affect system whereas conventional stationary noise models effective elsewhere elsevier ltd rights reserved
goal models represent requirements intentions software system play important role development life cycle software product lines spls domain engineering phase goal models guide development variability spls providing rationale variability used configuration spls application engineering phase however variability spls represented feature models usually design implementation induced constraints constraints aligned variability goal models configuration goal models becomes error prone remedy problem propose description logic based approach represent models relations common knowledge base moreover apply reasoning detect inconsistencies variability goal feature models formal proof provided demonstrate correctness reasoning approach empirical evaluation shows computational tractability inconsistency detection
default mode network dmn encompasses brain systems exhibit coherent neural activity rest dmn brain systems implicated diverse social cognitive affective processes well risk forms dementia psychiatric disorders associate systemic inflammation areas anterior cingulate cortex acc surrounding medial prefrontal cortex mpfc within dmn implicated specifically regulating autonomic neuroendocrine processes relate systemic inflammation via bidirectional signaling mechanisms however still unclear whether indicators inflammation relate directly coherent resting state activity acc mpfc areas within dmn accordingly tested whether plasma interleukin indicator systemic inflammation covaried resting state functional connectivity dmn among adults aged male caucasian independent component analyses applied resting state fmri data generate dmn connectivity maps voxel wise regression analyses used test associations dmn connectivity across individuals controlling age sex body mass index fmri signal motion within dmn covaried positively connectivity sub genual acc negatively region dorsal medial pfc corrected statistical thresholds novel findings offer evidence unique association marker systemic inflammation acc mpfc functional connectivity within dmn network may important linking aspects immune function psychological behavioral states health disease elsevier inc rights reserved
objective examine fatty acid profiles response omega fatty acid omega supplementation associations clinical status treatment response youth mood disorders methods placebo controlled design year olds parallel pilot trials depression bipolar randomly assigned weeks omega supplementation eicosapentaenoic acid epa docosahexaenoic acid dha omega per day psychoeducational psychotherapy pep combination placebo mainly oleic linoleic acid alone blood drawn baseline endpoint fatty acid levels expressed percent total plasma fatty acids correlational moderator mediator analyses done spss statistics results baseline dha correlated negatively alpha linolenic acid ala arachidonic acid omega correlated negatively global functioning total omega correlated negatively age diastolic blood pressure moderation baseline ala moderated response omega supplementation ala levels sample mean lower dha predicted significantly better placebo controlled response supplementation effects compared placebo omega per day increased epa blood levels sevenfold dha levels half body weight correlated inversely increased epa dha positively clinical mood response mediation epa increase baseline endpoint mediated placebo controlled global function depression improvement greater epa increase less placebo controlled omega improvement conclusion omega supplementation day increases blood levels substantially smaller children possible ushaped response curve explored
dearth scientific knowledge currently exists regarding human nonverbal predictors violence using sample adults study sought identify series nonverbal behaviors research participants perceived associated communication imminent violence assuming boxer stance invading personal space clenched hands threatening remarks almost uniformly associated impending violence several gestures behaviors also perceived associated violence lesser degree behaviors least perceived associated violence crying rapid eye blinking placing hands hips avoiding eye contact analyses sex race found minor substantively insignificant differences suggesting perceptions may innate rather cultural
soil salinization one common land desertification processes found worldwide certainly severe environment hazard threatens stability ecosystems rapid inexpensive tool remote sensing technology combining measurements soil spectra widely concerned identifying mapping salt effect lands however effects soil moisture often immerge effects salt soil reflectance spectra soil moisture became major factor restrict soil salinity monitoring soil reflectance high soil moisture content lead failure soil salinity estimation soil reflectance data paper semianalytical model using exponent function developed estimate soil salt content ssc different moisture levels based control laboratory experiment root mean square error mean relative error respectively model applied estimate sscs wet soil reflectance sum considering effects soil moisture soil salt soil reflectance semianalytical model reduced ssc estimated error approach presented paper provides new way estimating soil salinity soil spectra various soil moisture conditions potential application large scale ssc mapping
phytoene synthase psy key regulatory enzyme carotenoid biosynthesis pathway plants present study examines role psy carotenogenesis stress management banana germplasm screening indian cultivars showed nendran dry weight rasthali dry weight contained highest lowest amounts beta carotene respectively ripe fruit pulp nendran ripe pulp also showed significantly higher antioxidant activity compared rasthali meta analysis three banana psy genes mapsy mapsy mapsy performed identify structural features subcellular chromosomal localization banana genome distinct expression patterns mapsy mapsy mapsy genes observed various tissues fruit developmental stages two contrasting cultivars suggesting differential regulation banana psy genes positive correlation observed expression mapsy beta carotene accumulation ripe fruit peel pulp nendran presence stress responsive cis regulatory motifs promoter region mapsy genes correlated expression pattern various stress abscisic acid methyl jasmonate salicylic acid dark treatments positive modulation mapsy noticed abiotic stresses suggested role plant physiological functions defense response amino acid sequence analysis psy proteins contrasting cultivars revealed psy comprises conserved domains related enzyme activity bacterial complementation assay validated functional activity six psy proteins among psy nendran nen psy gave highest activity data provide new insights regulation psy expression banana developmental stress related signals explored banana improvement programs
paper presents novel reduced order model rom thrust efficiently flapping airfoil using system identification method naca airfoil pitching plunging low reynolds number used test rom unlike conventional aerodynamic models introduce airfoil displacements directly inputs study utilizes quadratic terms displacements inputs overcome frequency doubling effect propulsion forces oscillation frequency autoregressive exogenous input arx model adopted construct mappings input output data meanwhile heuristic searching strategy applied sensitivity analysis input variables optimal input vector determined roms validated time domain comparing predicted thrust responses cfd simulations either harmonic random excitations results show proposed roms accurately predict thrust responses flapping airfoil arbitrary motions moderate small oscillation amplitudes leading edge vortex develop computational cost reduced nearly orders magnitude compared high fidelity cfd simulation method finally validity roms mostly clearly shown using propulsive characteristic analysis flapping airfoil excellent qualities roms indicate used flapping mode optimization flapping flight control future research
study presents comprehensive investigation aerostatic buffeting response characteristics suspension bridge catwalk three dimensional aerostatic response analysis carried taking account geometric nonlinearity nonlinear dependence wind loads angle attack buffeting response analysis performed time domain aerostatic buffeting responses catwalk show strong coupling vertical lateral vibrations lateral displacement main component wind induced static buffeting response catwalk
background asparaginase asp associated venous thromboembolism vte serious adverse complication associated acute lymphoblastic leukemia lymphoma treatment incidence rate asp related vte asian cancer patients well known methods performed population based study using claim databases including diagnostic medication codes anti cancer treatment asp vte diagnoses starting date months cessation asp results total patients prescribed asp treatment type lymphoid malignancy including lymphoma patients experienced vte common site thrombosis upper extremities cerebral vein thrombosis occurred two pediatric patients pediatric patients adult patients suffered vte respectively lymphoma patients diagnosed vte asp exposure univariate analysis diagnosis lymphoma adult patient pediatric patient risk factors vte occurrence however multivariate analysis age remained risk factor vte odds ratio confidence interval conclusions first largest population based study asian patients lymphoid malignancies treated asp demonstrating adult patients elevated risk thrombosis asp exposure overall incidence asp related vte amongst patients similar caucasian populations
urban environments increasingly pervaded embedded networks mobile digital components capable sensing computing acting real time augmented environments capability dynamically respond adapt context behavioral patterns human occupants forms interaction fluid hoc paper proposes framework based improvisation analysis design environments following study nature improvisation process systems view improvisation adopted structural elements viewpoints improvisation technique mapped design stages second order systems develop framework design interactive urban environments
background chronic kidney disease ckd patients clinicians seek ways mitigate risk ckd progression associated complications emerging data suggest dietary modifications may beneficial adjuvant approaches reducing risk adverse ckd outcomes summary review focuses several different dietary patterns including dietary approaches stop hypertension mediterranean diets kidney health benefits discuss healthful dietary patterns lower dietary acid load improving diet quality may slow progression ckd also discuss barriers may impede socially disadvantaged individuals following healthful diets key points dietary patterns low dietary acid load might slow progression ckd current evidence suggests reduction dietary acid load could beneficial patients ckd supremacy particular diet yet established additional randomized controlled dietary interventions among ckd patients needed inform evidence based recommendations tailored individual preferences ability access healthful foods karger basel
goal study determine people endorsement different moral foundations influences degree prosocial behavior set economic exchange games moral foundations theory proven useful means categorizing ideas morality predicting opinions aspects social justice political orientation constructs related prosocial behavior study sought determine progressivism degree individuals endorse individualizing moral foundations harm care fairness reciprocity binding moral foundations group loyalty authority respect purity sanctity would lead frequent cooperation prisoner dilemma higher level investment trust game higher level return one partner investment trust game fewer points stolen thieves game results indicated relationship progressivism performance thieves game three separate linear regressions controlling age gender race big personality traits progressivism associated frequent cooperation prisoner dilemma higher level investment trust game higher level return one partner investment trust game therefore appear moral foundations predict performance economic exchange games greater endorsement progressivism associated prosocial behavior elsevier ltd rights reserved
many agitation mixing processes utilize various sensors real time monitoring control involve complex costly equipment many mixing agitation processes dough making mixing energy placed resistance extension increases point decreases high quality bread obtained stopping mixing close maximum resistance change resistance causes change motor torque torque change affects motor current draw agitation mixing machines driven electrical motors rheological characteristics mixed material related motor torque mixing machine therefore related motor electric current load variation estimated low cost current sensor paper outlines novel design intelligent agitator mixer process controller design based current sensing line learning reinforcement learning using operator input system provides low cost approach automate various kinds production equipment currently operated manually common developing world additionally approach requires minimal modification equipment requires current sensor control relay set buttons operation embedded system published elsevier ltd
destination memory refers ability remember piece information previously transmitted paper assessed ability schizophrenia twenty five patients schizophrenia control participants told proverbs send thief catch thief pictures celebrities elvis presley afterward participants indicate celebrity previously said proverbs participants also completed binding task required associate letters corresponding context location analysis revealed worse destination memory binding patients schizophrenia controls populations destination memory significantly correlated performances binding task findings suggest difficulty ability attribute information appropriate destination schizophrenia difficulty may related compromise binding separate cues together form coherent representation event memory
zero suppressed binary decision diagrams zdds widely used data structures representing handling combination sets boolean functions particular zdds commonly used cad synthesis verification integrated circuits purpose article design error resilient version data structure self repairing zdd precisely design new zdd canonical form called index resilient reduced zdd faulty index reconstructed time number nodes corrupted index moreover propose new versions standard algorithms zdd manipulation construction error resilient execution produce index resilient zdd output experimental results validate proposed approach
performing cryptanalysis interest approximate boolean function variables affine functions usually assumed input vectors boolean function equiprobable mounting affine approximation attack fast correlation attacks paper consider general case component input vector independent identically distributed bernoulli variates parameter since scope within area cryptography initiate analysis cryptographic boolean functions previous considerations derive expression analogue walsh hadamard transform nonlinearity case consideration observe allow take complex values framework involving quantum boolean functions introduced provides connection walsh hadamard transform nega hadamard transform boolean functions biased inputs
mesh denoising imperative improving imperfect surfaces acquired scanning devices main challenge faithfully retain geometric features avoid introducing additional artifacts removing noise unlike existing mesh denoising techniques focus either first order features high order differential properties approach exploits synergy facet normals quadric surfaces integrated recover piecewise smooth surface specific vote surface normal tensors robust statistics guide creation consistent subneighborhoods subsequently used moving least squares mls voting naturally leads conceptually simple way gives unified mesh denoising framework handling noise also enabling recovering surfaces sharp small scale features effectiveness framework stems multiscale tensor voting avoids influence noise effective energy minimization strategy searching consistent subneighborhoods piecewise mls fully prevents side effects different subneighborhoods surface fitting framework direct practical easy understand comparisons state art methods demonstrate outstanding performance feature preservation artifact suppression note practitioners three dimensional sensing scanning devices widely used capture digital surfaces real objects scenes many scenarios however due occlusion motion multiple reflections captured data often suffer severe contamination noise significantly hindering practical applications therefore indispensable remove noise prior processing commonly referred mesh denoising mesh denoising long standing problem remains open academic well industrial applications due challenging nature state art methods either fail retain original features presented well object avoid additional artifacts vertex drifts contrast design denoising framework aiming improving quality raw surface producing mesh better perceptual features technique developed produce high quality surface data real objects scenes would facilitate modeling reconstruction recognition applications computer aided design reverse engineering printing computer aided manufacturing
background malaria big problem public health many tropical countries socioeconomic development deficient four species plasmodium capable infecting human falciparum malaria vivax ovale southeastern corner iran including sistan baluchestan hormozgan tropical part kerman province endemic region malaria study aimed find clinical findings malaria caused various plasmodium species moderate transmission area southern kerman province methods study conducted health centers kahnooj manujan ghale ganj roudbar fariab south kerman province southeastern iran three hundred thirty patients positive malaria parasite slides entered study frequencies several malaria clinical presentations investigated four plasmodium species results considered patients male mean age patients younger older patient months respectively ten patients infected falciparum plasmodium vivax mixed infection symptoms fever chills sweating present subjects complaints joint pain headache fatigue vomiting diarrhea splenomegaly detected individuals conclusion malaria considered differential diagnosis acutely febrile patients endemic area classic symptoms fever chills sweating may present patients
current study investigated ventromedial prefrontal cortex vmpfc activity impression formation individuals varying distinct dimensions social status block design functional magnetic resonance imaging fmri experiment participants presented photographs faces paired colored background indicating lower higher financial status lower higher moral status participants asked form impression targets instructed explicitly evaluate based social status building previous findings cloutier ambady meagher gabrieli region interest analysis revealed interaction status dimension level vmpfc finding preferential response targets higher compared lower moral status previously demonstrated also greater response targets lower compared higher financial status implications results discussed emphasis towards better understanding impact social status social cognition uncovering neural substrates person evaluation elsevier inc rights reserved
guiding mechanism based flexure hinges fhs widely used micro nano manufacturing technology stiffness frequency fhs play significant roles dynamic performance design task structure find optimal topology corresponding size fhs stiffness frequency constraints however existing optimization methods pay attention stiffness frequency constraint owing difficulties dynamic topology optimization article symmetrical layout assumption fhs analytical equivalent stiffness mass expression single simultaneous topology size optimization problem converted analytical optimization formula discrete continuous variables finally tension stiffening effect used compensate manufacturing errors design case used illustrate efficiency proposed method
subclinical hyperthyroidism known associated risk fractures elderly people however studies assessing whether low normal thyroid stimulating hormone tsh levels affect bone density geometry aimed assess influence tsh level bone mineral density bmd geometry elderly euthyroid subjects cross sectional cohort study total men women euthyroidism included analyzed separately subjects divided tertiles based serum tsh level bmd geometry measured using dual energy ray absorptiometry hip structural analysis program multiple regression analysis used compute odds ratios osteoporosis lower tsh tertile group association geometry parameters tsh level found femoral neck total hip bmds lower lower tsh tertile group women cross sectional area cortical thickness femur negatively associated tsh level three regions narrow neck intertrochanter femoral shaft however men geometry parameters significantly associated tsh level intertrochanter region buckling ratio bone geometry parameter representing cortical instability significantly higher lower tsh tertile group three regions women men results indicated lower tsh levels euthyroid range related lower bmd weaker femoral structure elderly women
introduction changes personality described parkinson disease suggestion established disease tend risk averse disinclination addictive behaviour however little known earliest prodromal stages personality relationship addictive behaviours help answer important questions mechanisms underlying addiction methods population ascertained subjects within years diagnosis patients rapid eye movement sleep behaviour disorder rbd control subjects fully characterised motor symptoms non motor symptoms across following personality domains neuroticism extraversion conscientiousness agreeableness openness using big five inventory results patients early neurotic less extraverted less open controls rbd subjects showed pattern neurotic less extraverted less open patients smoked less drunk less alcohol controls caffeine beverage consumption similar extraverted open less neurotic predicted higher alcohol use extravert less agreeable associated smoking conclusions similar pattern personality changes seen rbd compared control population personality characteristics associated addictive behaviours suggestive common link lower rates addictive behaviours onset motor symptoms persisted accounting personality authors published elsevier ltd
reality television highly popular genre growing body scholarly research unlike scripted programming offers fictional storylines reality television relies heavily cast member reactions carefully crafted situations study examined relationship reality television gender role stereotyping seminal reality television show mtv jersey shore content analysis used conduct depth examination first season jersey shore investigating three gendered issues physical appearance social roles behavioral traits findings demonstrated carefully manufactured relationship gender role stereotyping reality television programming jersey shore illustrate development female reality show character related sexualized behavior social emotional gender stereotypes depiction female reality show characters seems increased level sensationalism continuing cliched conventional depiction male characters beginning push boundaries typecast regards physical appearance role performing domestic tasks additionally physical alterations screen many warranting investigation behavior
introduction incorrect use flowers leaves seeds plants members general public give rise serious toxicities datura innoxia also known pipe grass weed wizard frequently used treatment asthma cough alleviate cramps however also hallucinogenic tremendous potential abuse cause anticholinergic toxicity serious fatal complications coma respiratory failure death reported case report present cases two women years old years old admitted emergency department findings anticholinergic toxicity including mydriasis agitation delirium taking patients pupils widely dilated gastric decontamination administration activated charcoal fluids midazolam diazepam performed patients general conditions recovered except mydriasis however week diameter patients pupils returned normal conclusion unconscious misuse plants cause fatal anticholinergic toxicity toxicity though rarely reported plants known cause toxicity usually endemic clinicians alert potential anticholinergic toxicity patients present anticholinergic symptoms endemic areas
atrial fibrillation heart failure reduced ejection fraction hfref frequently coexist complicates course treatment recent population based studies demonstrated conditions together increase risk stroke heart failure hospitalization cause mortality especially soon clinical onset guideline directed pharmacological therapy hfref important however although various treatment modalities clear consensus best treat concomitant hfref depth review discusses available data treatment setting hfref focuses areas investigation necessary examines clinical implications randomized observational clinical trials presents suggestions individualized treatment strategies specific patient groups
ethylhexyl phthalate dehp known endocrine disrupting properties previously demonstrated prenatal dehp exposure associated decreased progesterone levels testosterone estradiol ratio cord blood however evidence effects prenatal dehp exposure adrenal androgen glucocorticoids infants scarce thus objectives study investigate association prenatal dehp exposure adrenal androgen glucocorticoids discuss effects steroid hormone profiles infants part birth cohort study hokkaido study environment children health sapporo cohort among participants mother infant pairs available data maternal mono ethylhexyl phthalate mehp adrenal androgen dehydroepiandrostenedione dhea androstenedione glucocorticoid cortisol cortisone cord blood levels included study adjusting potential confounders linear regression analysis showed maternal mehp levels associated reduced cortisol cortisone levels glucocorticoid adrenal androgen ratio whereas increased dhea levels dhea androstenedione ratio quartile model comparing adjusted least square means quartile mehp quartile cortisol cortisone levels glucocorticoid adrenal androgen ratio decreased whereas dhea androstenedione cortisol cortisone ratios increased significant value trends cortisol cortisone levels cortisol cortisone ratio glucocorticoid adrenal androgen ratio observed combination previous results reduced progesterone levels testosterone estradiol ratio prenatal exposure dehp altered steroid hormone profiles infants studies investigating long term effects dehp exposure growth neurodevelopment gonad reproductive function required elsevier rights reserved
paper studies regularized least squares regression problem arises many applications signal processing machine learning iterative thresholding algorithm important algorithm solving problem viewed jacobi type iterative method paper proposes gauss seidel version iterative thresholding algorithm called gaita solving problem certain conditions establish global convergence eventual linear rate convergence local minimizer compared jacobi counterpart proposed algorithm allow larger step sizes converge much faster effectiveness proposed algorithm justified numerical experiments synthetic data real data elsevier rights reserved
background ability analyze genomics malignancies opened new possibilities label targeted therapy cancers refractory standard therapy mayo clinic efforts organized center individualized medicine cim results prior gtb datasets analyzed integrated team bioinformaticians cancer biologists therapeutically actionable mutations identified patients tested receiving genomically targeted therapy fda approved drugs independent clinical trial responding standard care soc options continued patients tested exhausting soc options responding treatment patients actionable targets treated choosing comfort measures passing away materials methods patients referred cim clinic october december patients received clinical genomic panel testing selected subsets receiving array comparative genomic hybridization clinical whole exome sequencing complement validate panel findings genomic tumor board gtb reviewed results possible developed treatment recommendations conclusions treatment decisions driven tumor genomic analysis lead significant clinical benefit minority patients success genomically driven therapy depends access drugs robustness bioinformatics analysis novel clinical trial designs increasing utility genomic testing robust data sharing outcomes needed optimize clinical benefit patients
paper generalized higher order variable coefficient nonlinear schrodinger equation studied describes propagation subpicosecond femtosecond pulses inhomogeneous optical fiber derive set integrable constraints variable coefficients constraints via symbolic computation modified hirota method bilinear equations one two three soliton solutions dromion like structures obtained properties interactions solitons studied effects solitons resulting wave number third order dispersion group velocity dispersion gain loss group velocity related discussed analytically graphically normalized propagation distance along fiber bound state different values presented periodic quasiperiodic formulae derived interactions two solitons bound states single soliton respectively discussed single double triple dromion like structures different values also presented distortions found determined variable coefficients
previous observational research suggests stretching contagious budgerigars melopsittacus undulatus report first experimental evidence response reanalysis previous experiment testing contagious yawning species using repeated measures design birds tested pairs alongside familiar unfamiliar conspecifics without visual barriers results show stretching behavior temporally clustered birds could see one another corroborating previous observational findings supporting contagion additionally first time show ingroup bias response overall frequency stretching significantly differ function conspecific familiarity contagious stretching present cage mates paired together findings discussed relation recent research studying social cognition species
ambient intelligence ami paradigm represents vision next wave computing relying various computing networking techniques ami systems potential enhance everyday lives many different aspects one area widespread application innovative paradigm promises particularly significant benefits health care work presented contributes realizing promise proposing functioning software application able learn behaviors habits thereby anticipate needs inhabitants living technological environment smart house city result health care system actively contribute anticipating thereby preventing emergency situations provide greater autonomy safety disabled elderly occupants especially cases critical illness
addition endorsing content stigmatizing thoughts self stigma content frequently automatically individuals think thoughts self stigma process also implications well present study examined roles self compassion mindfulness moderating relationships self stigma content process subjective well people recovery mental illness pmi people living hiv plhiv participants included pmi plhiv hong kong reported levels self compassion mindfulness self stigma content process life satisfaction path analyses indicated proposed model fitted two samples well chi cfi nnfi rmsea groups self compassion mindfulness significantly associated life satisfaction self compassion moderated relationship self stigma content life satisfaction among plhiv mindfulness moderated relationship self stigma process life satisfaction among pmi differential moderating roles self compassion mindfulness buffering effects self stigma content process among pmi plhiv identified implications stigma reduction well promotion different stigmatized groups discussed
flow generated oscillating sphere quiescent fluid classical problem fluid mechanics whose solution used ubiquitously miniaturisation mechanical devices small scales operation high frequencies fluid common modern nanomechanical systems preclude use unsteady stokes equation continuum flow explore combined effects gas rarefaction unsteady motion sphere within framework unsteady linearised boltzmann bgk bhatnagar gross krook equation equation solved using method characteristics resulting solution valid oscillation frequency arbitrary degrees gas rarefaction resulting force provides non continuum counterpart continuum unsteady stokes drag sphere contrast stokes solution flow isothermal non continuum effects lead temperature jump sphere surface non isothermal flow unsteady effects heat transport found mix strongly leading marked differences relative steady case solution canonical flow problem expected significant practical value many applications including optical trapping nanoparticles design application nanoelectromechanical systems also provides benchmark computational approximate methods solution boltzmann equation
identification treatment responders challenge comparative studies treatment efficacy measured multiple longitudinally collected continuous count outcomes existing procedures often identify responders basis single outcome propose novel multiple longitudinal outcome mixture model assumes conditionally cluster label longitudinal outcome generalized linear mixed effect model utilize monte carlo expectation maximization algorithm obtain maximum likelihood estimates high dimensional model classify patients according estimated posterior probability responder demonstrate flexibility novel procedure two multiple sclerosis clinical trial datasets distinct data structures simulation study shows incorporating multiple outcomes improves responder identification performance occur even outcomes ineffective general procedure facilitates identification responders comprehensively defined multiple outcomes various distributions copyright john wiley sons ltd
digital control method combining primary side sensing observer model predictive control techniques proposed conventional isolated flyback converter chosen demonstrating method measured signal drain source voltage switch following procedure signal processing state estimation constraint problem formulation controller determines optimal duty cycle ratio advantages proposed method include minimal overshoot fast stabilization converter state restriction measurement network simplification
paper presents dynamic model variable speed wind energy conversion systems equipped variable pitch wind turbine synchronous electrical generator full power converter specially developed use power system stability studies involving large networks high number buses high level wind generation penetration validity necessary simplifications contrasted detailed model allows thorough insight mechanical electrical behavior system interaction grid developed dynamic model implemented widely used power system dynamics simulation software pss performance tested well documented test power network elsevier ltd rights reserved
semiempirical reciprocating compressor model developed characterize time response pressure within compressed natural gas storage tank model assumes isentropic compression single stage compressor feeds isothermal reservoir compression heat assumed dissipate cylinder tank low order model utilizes key variables compression ratio cylinder volume tank volume engine speed yields reasonable approximation pressure inside tank time natural gas compressor used validate model unique automotive internal combustion engine heavily modified two distinct modes one mode engine cylinders fire normally providing locomotion natural gas vehicle mode one cylinder engine used compress low pressure residential natural gas multiple stages standard compressed natural gas vehicle storage tank pressure bar gauge found first order response model closely matches trend tank pressure time seen laboratory experiments typical error less
three connecting bolts fractured assembled fan used internal combustion engine detailed fractographic study metallurgical analysis focused fractured bolts fractographic metallurgical studies indicate fracture surface microstructure three bolts exhibit similar features fatigue fracture main failure mechanism bolts appearance micro cracks thread tip fractured bolts makes stress thread regions increase intensively fatigue cracks initiated thread regions due presence dynamic load bolts never properly tightened installation responsible formation cracks
coccidioidomycosis valley fever systemic fungal infection resulting inhalation coccidioides immitis posadasii spores many cases infection causes self limited community acquired pneumonia however patients risk factors immunosuppression african pacific island ancestry significantmorbidity mortality disseminated disease may occur presented comparative images using mdp bone scan fdg pet mri demonstrates particular strengths aid assessing extent systemic involvement biopsy proven case disseminated coccidioidomycosis
paper presents results experiments aiming quantitative assessment adverse effects arise electric drive powered alternating current power via long cable elimination negative influences used various types output emi electromagnetic interferences devices studied much mention devices reduce interfering influences mainly overvoltage peaks rate voltage rise
background virtually low middle income countries undergoing epidemiological transition whose progression varied experienced high income countries observed changes mortality disease patterns reveal transition low middle income countries characterized reversals partial changes simultaneous occurrence different types diseases varying magnitude localized characterization shifting burden frequently lacking essential guide decentralised health social systems effective targeting limited resources based rigorous compilation mortality data two decades paper provides comprehensive assessment epidemiological transition rural south african population methods estimate overall cause specific hazards death functions sex age time period mortality data agincourt health socio demographic surveillance system conduct statistical tests changes differentials assess progression epidemiological transition period results early population experienced reversal epidemiological transition driven mostly increased hiv aids related mortality recent years transition following positive trajectory result declining hiv aids related mortality however age groups cause death distribution yet reach levels occupied early transition also characterized persistent gender differences rapid positive progression females males conclusions typical rural south african population experiencing protracted epidemiological transition intersection interaction hiv aids antiretroviral treatment non communicable disease risk factors complex social behavioral changes impact continued progress reducing preventable mortality improving health across life course integrated healthcare planning program delivery required improve access adherence hiv non communicable disease treatment findings local rural setting extended period contribute evidence needed inform refinement advancement epidemiological transition theory
objective study weighted average global prevalence migraine community level study design setting systematic review using advanced search strategies employing pubmed medline scopus web science conducted community based non clinical studies combining terms migraine community based names every country worldwide spanning previous years january august methods accordance prisma moose guidelines meta analysis subgroup analysis performed identify pooled migraine prevalence examine cohort heterogeneity results total community based studies involving participants median age years male female ratio included global migraine prevalence random effects africa asia europe north america central south america pooled cohort stratified prevalence among females among males among urban residents among rural residents among school college students result showed pattern rising global migraine prevalence conclusion migraine affects one ten people worldwide featuring recent rise higher prevalence found among females students urban residents elsevier rights reserved
background china rapid urbanization past decades exacerbated problems environmental degradation health disparities however studies analysed differences urban rural residents relation environmental quality impacts health outcomes study examines associations chinese people perceptions environmental quality self rated health particularly focusing differences rural urban residents environment health relationships methods using logistic regression model data chinese general social survey cgss representative sample data urban residents years rural residents years analysed dependent variable used logistic regressions whether respondents reported healthy independent variables included respondents evaluations living environment frequently participated physical activities interaction terms employed measure moderating effects physical exercise relationship perceived environmental quality health results percentage healthy urban residents significantly larger healthy rural respondents versus urban respondents living areas sufficient green space likely report good health rural respondents without reliable access fresh water likely report poor health urban respondents exposed green spaces exercised frequently per cent likely report good health exercised infrequently lived areas insufficient green space exercised frequently per cent less likely report good health exercised infrequently evidence suggested physical exercise exerted moderating effect relationship exposure air pollution health conclusions average urban residents better health rural residents among four indicators low environmental quality air pollution lack green spaces water pollution uncertain access freshwater resources green space important determinant urban residents health status unreliable access fresh water harmed rural residents health physical exercise moderated effects exposure green spaces urban residents health
online language learning teaching multimodal contexts identified one key research areas computer aided learning call lamy white paper aims explore meaning making online language learner interactions via desktop videoconferencing dvc illustrate multimodal transcription analysis well application theoretical frameworks fields recordings learner dvc interactions interviews qualitatively analysed within case study methodology analysis focuses semiotic resources available dvc used meaning making drawing semiotics interactional sociolinguistics nonverbal communication multimodal interaction analysis conversation analysis findings demonstrate use contextualization cues five codes body paralinguistic elements emotional expression gestures overlapping speech meaning making paper concludes recommendations teachers researchers using investigating language learning teaching multimodal contexts
flexural resonators operated within fluid time limited viscous damping nonetheless depending resonator geometry significant acoustic damping also considered reviewing main theoretical approaches proposed literature evaluate acoustic losses provide useful simplified expressions quantify corresponding quality factor original results obtained extending well known methods different shapes also present numerical simulations experiments compare assess validity predictions show analytical models combining viscous acoustic damping give reliable values observed quality factors elsevier rights reserved
live interesting times individuals members various communities organisations inhabitants planet earth face many challenges ranging climate change resource limitations market risks uncertainties complex diseases extent challenges arise complexity systems dealing problems arise understanding modelling controlling systems computing scientists professionals much contribute solving complex problems means computer systems software algorithms important part field talk focus one particular type complexity central interest evolutionary computation community artificial intelligence far beyond namely computational complexity particular hardness investigate question extent hard problems formidable often thought present overview several directions research aim characterise improve behaviour cutting edge algorithms solving hard problems pragmatic yet principled way prominent problems ranging propositional satisfiability sat tsp planning mixed integer programming mip demonstrate automated analysis design techniques used model enhance performance characteristics cutting edge solvers sharing surprising insights along way
extracellular potassium concentration major determinant neuronal excitability healthy brain levels tightly controlled seizures increases thought cause seizures due depolarizing effect although astrocytes suggested play key role redistribution spatial buffering excess connexin based gap junctions gjs relation dynamic regulatory process seizure generation remains unknown contrasted role astrocytic gis hemichannels studying effect hemichannel blockers regulation vivo measured sensitive microelectrodes neuronal excitability estimated local field potential lfp responses forepaw stimulation changes power resting state activity starting baseline level cortical microinjection cbx broad spectrum connexin channel blocker increased hemichannel blocker gap increased levels seizures observed hemichannel blockade tat gap increased microinjection aminopyridine known convulsant increased induced spontaneously recurring seizures whereas direct application trigger seizure activity findings first vivo demonstration astrocytic gjs major determinants spatial buffering increase alone trigger seizures neocortex elsevier inc rights reserved
electromagnetic structure phase shift autotransformer psat introduced operation psat connection double steps rectifier discussed algorithm deduction main design quantities machine described circuit model psat arrived circuit analysis allows deducing quantities machine design performed inputs thermal analysis results thermal analysis machine designed built authors shown
known objectivenephrotoxicity recognized side effect cisplatin chemotherapy however optimal strategy preventing cisplatin induced nephrotoxicity remains unclear primary objective study determine whether mannitol furosemide provides better nephroprotection administered hydration prior weekly low dose cisplatin concurrently whole pelvic radiotherapy methodsclinical data abstracted women underwent chemoradiation figo iva cervical cancer regional safety net health system january december creatinine clearance estimated using idms traceable mdrd study equation descriptive statistics used summarize patient demographics cox proportional hazard models used identify factors associated hypomagnesemia survival results discussiona total women received weekly doses single agent cisplatin concomitant whole pelvic radiation furosemide administered intravenously prior cisplatin doses whereas mannitol administered prior doses significant magnesium wasting observed second weekly cisplatin infusion regardless whether furosemide mannitol utilized repetitive low dose cisplatin infusion impact measured levels serum creatinine estimated glomerular filtration rate prior history hypertension diabetes mellitus hepatitis infection acute gastrointestinal toxicity associated early onset hypomagnesemia new conclusionsrepetitive administration low dose cisplatin concurrent whole pelvic radiation associated magnesium wasting however choice diuretic pretreatment hydration significant impact severity adverse effect
paper wide spread mathematical models deterministic chaos transistor oscillators considered models describe dynamic processes take place transistor colpitts oscillators variations deterministic chaos transistor oscillator schemes presented phase portraits time spectral diagrams chaotic oscillation obtained
rural residential areas low resident density areas usually distressed lack municipal infrastructure causes poor supply water energy well shortage waste pollution disposal equipment courtyard integrated ecological system cies example ecological engineering solution problem cies originated hainan rural area china family level symbiotic system designed authors according sustainable principles making good use local natural resources low cost convenience operation resource recycling cies systematically integrated series single techniques vertical planting hydroponic farming artificial wetland rainwater harvesting automatic management brief introduction cies design article also studied economic environmental benefit one year monitoring data comparison cies pattern traditional pattern emergy analysis carbon footprint analysis methods results showed cies could provide increase green land green volume vegetables rural family addition family could save kwh electric power fresh water chemical fertilizer pesticides year additionally counting money saved cies produce rmb years payback compared traditional living pattern local area cies pattern costs former emergy carbon footprint traditional living pattern assuming cies applied half rural households hainan province farmer would receive extra rmb year emergy consumed system would reduced sej emissions would reduced elsevier ltd rights reserved
objectives aim explore experiences iranian postmenopausal women sought medical help symptomatic vulvovaginal atrophy vva methods five focus group discussions fgds conducted participants postmenopausal bothersome symptoms vva came clinic previously sought medical help vva confirmed physical signs vva upon examination gynecologist results twenty five women aged years participated five fgds twenty women said currently vva symptom presentation clinic four major themes emerged women narrative stories negative impact vva women life psychological distress associated vva negative impact vva marriage relationship inadequate symptom relief available treatments due lack awareness vva treatment options none participants reported ongoing treatment vva local low dose estrogen women commented although local estrogen products costly would like use prescribed conclusions considering negative impact vva symptoms women lives health professionals iran prescribing approved effective therapies symptomatic women
thin porous materials spontaneously transport oil fluids single direction great potential making energy saving functional membranes however little data preparation functionalities smart material report novel method prepare one way oil transport fabrics application detecting liquid surface tension functional fabric prepared two step coating process apply flowerlike zno nanorods fluorinated decyl polyhedral oligomeric silsesquioxanes hydrolyzed fluorinated alkylsilane fabric substrate upon one sided irradiation coated fabric shows one way transport feature allows oil fluid transport automatically unirradiated side irradiated surface stops fluid transport opposite direction fabric still maintains high superhydrophobicity treatment one way fluid transport takes place oil fluids specific surface tension value fluid selectivity dependent treatment time changing irradiation time broadened one way transport fluids surface tension around range proved selective one way oil transport used estimate surface tension liquid simply observing transport feature series fabrics different one way oil transport selectivities knowledge first example use one way fluid transport materials testing liquid surface tension may open theoretical studies development novel fluid sensors
study reports results researcher administered survey patients receiving chronic opioid therapy days obtain information regarding chronic opioid therapy started chronic opioids started surgery confidence interval treatment acute injury related pain many initiated opioid therapy surgery reported postoperative complications many injury related pain reported follow corrective surgery led continuation opioids large percentage patients concurrent depression anxiety many participants medical history aberrant drug related behavior self reported history addiction almost one quarter reported taking opioids different indication opioids started patients receiving long term opioid therapy often transitioned chronic use starting opioids short term treatment postoperative injury related pain evident clear decision continue opioids chronic basis made survey provides insight chronic opioid therapy started may suggest opportunities improved patient selection opioid therapy perspective article explores reasons patients using chronic opioid therapy days initiated opioid medications results study may help clinicians better select patients chronic opioid therapy american pain society
recent applications passive microwave remote sensing techniques estimate snow water equivalent swe increasingly rely comprehension microwave emission theories instead traditional empirical fitting approaches study advanced swe retrieval algorithm based markov chain monte carlo method developed method samples posterior multiple layer snow properties according likelihood brightness temperature simulation actual observations microwave emission model layered snowpacks improved born approximation memls iba used observation model using globally applicable method produce prior estimates snow properties retrieval approach called bayesian algorithm swe estimation passive microwave measurements base applied snowpits sodanlcyla finland churchill canada colorado result shows root mean squared rms error retrieved swe excluding two outliers outliers well six deep snowpits colorado excluded accuracy approximately meets requirement integrated global observing strategy shallow snow poor performance outlier deep snowpits explained additional experiments using accurate priors show swe retrieval accuracy improved local snowcover knowledge historical snowpit measurements snow process model simulations available elsevier inc rights reserved
capture influences uncertain factors river bridge safety evaluation probabilistic approach adopted systematic nonlinear problem mpp based reliability analyses suitable sampling approach monte carlo simulation mcs importance sampling often adopted enhance efficiency sampling approach study utilizes bayesian least squares support vector machines construct response surface followed mcs providing precise safety index although several factors impacting flood resistant reliability bridge previous experiences studies show reliability bridge plays key role thus goal study analyze system reliability selected bridge includes five limit states random variables considered include water surface elevation water velocity local scour depth soil property wind load first three variables deeply affected river hydraulics probabilistic hec ras based simulation performed capture uncertainties random variables accuracy variation solutions confirmed direct mcs ensure applicability proposed approach results numerical example indicate proposed approach efficiently provide accurate bridge safety evaluation maintain satisfactory variation
facility huff location problem aims locating facilities competitive environment maximize market share deeply studied field continuous location paper study facility huff location problem networks formulated mixed integer nonlinear programming problem solved branch bound algorithm propose two approaches initialization division subproblems first one based straightforward idea enumerating every possible combination edges network possible locations second one defining sophisticated data structures exploit structure combinatorial continuous part problem bounding rules designed using difference convex interval analysis tools computational study compare two approaches battery networks show handle problems reasonable computing time elsevier rights reserved
purpose age related macular degeneration amd leading cause irreversible visual loss developed countries etiology includes genetic environmental factors although vegfa variants associated amd joint action variants within vegf pathway interaction nongenetic factors investigated methods affymetrix chipsets used genotype single nucleotide polymorphisms snps amd cases controls environmental exposures collected questionnaire set based test conducted using chi statistic snp derived kraft two degree freedom joint test pathway gene based test statistics calculated mean independent snp statistics phenotype labels permuted times generate empirical value results main effect vegf pathway identified pathway associated neovascular amd women accounting birth control pill bcp use analysis vegf subpathways showed snps proliferation subpathway associated neovascular amd accounting bcp use nominally significant genes within subpathway also observed stratification bcp use revealed novel significant genetic effects women taken bcps conclusions results illustrate amd genetic risk factors may revealed complex relationships among risk factors considered shows utility exploring pathways previously associated genes find novel effects also demonstrates importance incorporating environmental exposures tests genetic association snp gene pathway level
construction quality control storehouse surfaces major concern construction management roller compacted concrete rcc dams construction quality special dam filling material rcc affected many factors including rolling compaction concrete temperature construction climate storehouse surfaces timely collection comprehensive analysis construction data entire construction process storehouse surfaces subsequent feedback construction operations site key issues control construction quality thus obtain greater attention traditional methods construction quality monitoring including manual inspections sampling tests labor intensive easily lead indiscoverable irreparable quality defects present study real time construction quality monitoring method storehouse surfaces rcc dams proposed auto identification compacted layers realized based integration global positioning system gps global navigation satellite system glonass techniques sensor technology network transmission technology real time construction quality monitoring system developed applied ldl dam case study application results realize whole process weather timely monitoring rolling compaction quality concrete temperature construction climate compacted layer storehouse surfaces guarantees satisfactory construction quality high efficiency demonstrates effectiveness system moreover construction data used establish predictive models compactness loss vibrating compacted value applying multiple regression analysis method elsevier rights reserved
commercial distributed computing mode cloud computing needs meet quality service qos requirement users top priority however cloud computing service providers also need consider reduce overhead data center keep load balancing one key points maximize use resource data center paper propose improved multi objective niched pareto genetic algorithm npga take load balancing consideration without affecting performance time consumption financial cost handling user cloud computing tasks presenting load balancing shift mutation operator simulation results analysis show proposed algorithm performs better npga maintaining diversity distribution pareto optimal solutions cloud tasks scheduling population size evolution generation
background psychiatric disorders occur considerable proportion patients rheumatoid arthritis often reflecting difficulties patients coping chronic debilitating disorder aim study evaluate proportion anxiety disorder patients using large database analysis methods study designed case control population based study using data clalit health services chs database patients defined anxiety disorder least one documented diagnosis identified international classification diseases icd medical records proportion anxiety disorder compared patients controls logistic regression model used estimate association anxiety disorder multivariate analysis adjusted age gender socioeconomic status ses results study included patients age sex frequency matched controls proportion anxiety patients higher controls multivariate analysis found independently associated anxiety study shortcomings cross sectional nature allow make inferences causal relationship anxiety conclusion study confirms higher proportion anxiety patients especially young women low ses physicians aware findings therefore apply proper screening strategies
introduction fexofenadine fxf third generation antihistamine drug osthole assumed natural antihistamine alternative paper compares results histamine fxf osthole impact hrh cox ccr mrna expression also measured mrna expression beta ccl rantes incubated peripheral blood mononuclear cells pbmc compared histamine fxf osthole influence expression level interacts product secretion objective purpose investigate expression pattern asthma pbmc methods cultures treated fxf osthole measured mrna expression histamine hrh cox ccr beta ccl rantes real titne pcr pcr results present study suggest osthole may potential inhibitor histamine receptor activity also demonstrated cells cultured histamine increase cox mrna expression osthole reduce conclusion allergy remains one common chronic diseases europe rapidly approaching epidemic proportions current predictions estimating number allergy afflicted equal healthy population therefore paramount find new pharmaceuticals successfully combat allergic disease elsevier gmbh rights reserved
paper presents chip thermal flow sensor patterned outside polymer microfluidic channel sensor low power low hysteresis device excellent resolution min built calibration covering wide range typical lab chip flow rates features together compatibility approach current printing roll roll techniques prove realistic mass producible solution direct monitoring microfluidic protocols inside lab chip loc devices contrast commercially available flow sensors low price allows use disposable devices functionality microsensor tested microfluidic cell culture application nutrients flow rate monitored controlled results indicate successful performance sensor highly sensitive environment overall chip sensor approach offers significant improvements existing sensor devices academic commercial applications elsevier rights reserved
people often favor groups belong beyond group boundary yet group favoritism always occur people sometimes favor group group delineate theoretically group favoritism self protection group favoritism benevolence occur two experiments groups relative status competence stereotypes manipulated groups outcomes non contingent experiment contingent experiment allocating reward members low status group self protective favoring group group non contingent contingent outcomes high status benevolently favored group outcomes non contingent self protective contingent outcomes people willing engage social activities group member regardless competence however task collaboration implications self low status preferred competent less competent group members traits high status targets differentiated low status experiments whereas high status differentiated low status members traits outcomes contingent general principle fits data implications intergroup responses self determine benevolence self protection
paper developed design investigated performance kwe turbo machine unit space nuclear reactor power systems closed brayton cycle cbc energy conversion compressor turbine unit scaled versions nasa bru developed sixties seventies performance results turbo machine unit calculated rotational speed krpm variable reactor thermal power system pressure fixed turbine compressor inlet temperatures analyses used detailed turbo machine model developed university new mexico accounts various energy losses compressor turbine effect compressibility mole working fluid increased flow rate model also accounts changes physical transport properties working fluid temperature pressure results show unit efficiency achievable rotation speed krpm system pressure mpa assuming shaft electrical generator efficiencies corresponding net electric power output unit kwe flow rate working fluid pressure ratio polytropic efficiency compressor turbine
background variation cypa gene alters rate nicotine metabolic inactivation associated smoking behaviors cessation success rates underlying neurobiological mechanisms genetic influence unknown methods intrinsic functional connectivity strength whole brain data driven graph theory based method applied resting state functional magnetic resonance imaging data smokers nonsmokers subset subjects smokers nonsmokers performed monetary incentive delay task probing reward anticipation task probing response inhibition two occasions presence absence nicotine patch results significant cypa genotype smoking effect found dorsal anterior cingulate cortex ventral striatum normal slow genotype individuals showed greater functional connectivity strength among smokers nonsmokers functional connectivity strength negatively associated severity nicotine dependence slow metabolizers hubs biased inputs insula identified seed based connectivity similar gene environment interactions seen ventral striatum smoking abstinence subjects performed monetary incentive delay task dorsal anterior cingulate cortex performed task reductions normalized smokers increased nonsmokers acute nicotine administration conclusions cypa effect seen smokers data suggest rate nicotine metabolism thus concentration nicotine presented brain course nicotine addiction shapes brain circuits among functions compute reward impulsivity processes
hashing important technique achieve high code performance variety data processing applications concept emphasized computer science curricula industry values graduates use hashing skillfully although several implementation details hashing routinely handled software libraries remains responsibility programmer choose suitable hash function poor hash function degrade performance researchers designed number generic hash functions environments code development offer shelf solutions also curious textbooks reference books point learners rich resource paper remedies deficiency providing learners easy way compare hash function performance alternatives assistive tool eclipse plugin java programs focused traditional hash functions non cryptographic hash functions preserve distance however approach extended easily programming languages development environments hash function classes
backgroundacute worsening asthma symptoms exacerbation predominantly triggered respiratory viruses influenza causing severe exacerbations lack adequate animal model hampers mechanistic insight development new therapeutics aimwe developed characterized robust consistent reproducible mouse model severe exacerbation chronic allergic asthma methodschronic allergic airway inflammation induced following house dust mite hdm sensitization protocol hdm sensitized mice controls infected influenza virus either treated inhaled fluticasone propionate systemic corticosteroids pred anti mice killed different time points infection cellular accumulation cytokines levels airways penh measure airway hyper responsiveness ahr lung histology viral replication assessed resultsinfection low dose led prolonged deterioration lung function aggravated mucus production peri vascular peri bronchial allergic inflammation unresponsive inhaled corticosteroids responsive systemic corticosteroids exacerbation preceded virus exposure marked innate response subsequently followed enhanced numbers eosinophils neutrophils dendritic cells lung lumen parenchyma draining lymph nodes hdm sensitized mice anti treatment attenuated eosinophils prevented induced exacerbation conclusionstogether findings indicate early innate response involves eosinophils underlies exacerbation model recapitulates major features severe asthma exacerbations serve discern driving mechanisms promote development novel therapeutics
physical conception memristor hewlett packard labs opened possibility combining new fundamental circuit element traditional devices order carried novel applications important step incorporating memristor computer aided design tools find expression represents behavior device paper novel modeling methodology memristive systems using homotopy perturbation methods introduced methodology capable generating semi symbolical expression represents memristive behavior device new memristor model characterized order determinate impact variables memristive behavior establishes range compliance using principal fingerprints memristor besides novel memristor model depicted two cases study finally advantages memristor model presented discussed
system dynamics computer simulation modeling methodology one suitable effective ways dynamics modeling complex non linear natural technical organization systems studying dynamics behavior marine electric power systems one complex dynamic non linear technical systems requires application effective modeling methods aim paper show efficiency system dynamics computer simulation modelling dynamics behavior marine diesel drive generating set one complex non linear marine technical systems marine diesel drive generating set presented qualitative quantitative system dynamics computers model special automation aspect provided two unieg pid regulators electronics universal pid regulators one used diesel motor speed frequency regulation used synchronous electrical generator voltage regulation
social perception among important tasks occur daily life perceivers readily appreciate social affordances others demonstrate sex categorizations functionally biased towards male percept perceivers judged body shapes varied waist hip ratio men reality exclusive women male categorizations occurred quickly female categorizations studies pattern corroborated participants identified average body shapes men women study assessed participants cognitive representations study moreover tendencies modulated emotion context study thus male categorizations occurred readily rapidly demonstrating pronounced categorization bias temporal advantage male judgements
studies revealed upward social comparison social network sites snss risk factor depressive symptoms however little known underlying processes may mediate moderate relationship study extended prior research examining mediating role self esteem moderating role optimism relationship sample chinese undergraduate students completed measures upward social comparison snss depressive symptoms self esteem optimism results showed self esteem partially mediated relation upward social comparison snss depressive symptoms addition direct effect upward social comparison snss depressive symptoms mediating effect self esteem moderated optimism two effects potent individuals low optimism high optimism present study contributes better understanding upward social comparison snss increases risk depressive symptoms limitations implications study discussed elsevier ltd rights reserved
background delayed sleep phase syndrome dsps seasonal affective disorder sad may manifest similar delayed circadian phase problems however relationships comorbidity two conditions fully studied authors examined comorbidity dsps sad methods recruited case series dsps controls normal sleep roughly matched age gender ancestry dsps controls completed extensive questionnaires sleep morningness eveningness trait depression mania seasonality symptoms etc results prevalences sad subsyndromal sad sad higher dsps compared controls chi dsps times likely report sad odds ratio compared controls defined seasonal pattern assessment questionnaire spaq correspondingly dsps showed significantly higher seasonality scores compared controls mood appetite energy level subscores global seasonality score respectively weight fluctuation seasons winter summer sleep length differences also significantly higher dsps controls respectively sad sad reported significantly higher eveningness higher depression self ratings previous mania symptoms compared non seasonal subjects regardless whether dsps controls conclusions cases suggested dsps partially comorbid sad data support hypothesis dsps sad may share pathophysiological mechanism causing delayed circadian phase elsevier rights reserved
traditionally public professional debate inappropriateness media violence children focuses mainly negative effects violence entertainment programming however since terrorist attacks september recent coverage war iraq suitability real life news violence children may doubted ever draw attention potential harmful effects violence presented news programs argued present article health care professionals advocate broader conception media violence thus far used basis recent research potential effects violent news content fear aggression desensitization discussed recommendations provided abate outcomes
cysteine interesting biomolecule heavy metals trapping field thanks amino thiol carboxylic groups amino acid indeed present natural chelating agents glutathione phytochelatins metallothioneins however cysteine never used remediation processes immobilized polypropylene nonwoven geotextile innovative eco friendly material obtained potential use drainage filtration wastewaters sediments first functionalized acrylic acid using low pressure cold plasma process bring reactive carboxylic functions onto surface cysteine covalently grafted modified cysteine grafting optimized using response surface methodology allowed concluding best conditions immersion without heating consist solution containing mol cysteine materials characterized scanning electron microscopy infrared spectroscopy ray photoelectron spectroscopy evidence covalent cysteine grafting given preliminary sorption tests degrees artificially polluted solutions give promising results divalent heavy metal ions cuso solution counter ion per gram trapped elsevier ltd rights reserved
gut microbiota important regulator body homeostasis including intestinal extraintestinal effects review focuses bone axis define effect gutassociated microbial community molecules synthesize bone health research field limited findings preclinical studies support gut microbes positively impact bone mineral density strength parameters moreover administration beneficial bacteria probiotics preclinical models demonstrated higher bone mineralization greater bone strength preferential bacterial genus shown beneficial effects bone lactobacillus thus lactobacilli among best candidates future clinical intervention trials however effectiveness dependent stage development early life constitutes important time impacting bone health perhaps via modulation addition sex specific difference also impacts efficacy probiotics although auspicious many questions regarding bone axis require consideration potential mechanisms sex specific efficacy effective dose probiotics timing duration treatment abbreviations bmc bone mineral content bmd bone mineral density bone volume percentage total volume conv conventionalized conv conventionally raised crohn disease dxa dual energy ray absorptiometry germ free git gastrointestinal tract gut microbiota hydroxytryptamine ibd inflammatory bowel disease interleukin ibs irritable bowel syndrome lps lipopolysaccharide lbp lps binding protein ocl osteoclast opg osteoprotegrin ovx ovariectomized rank receptor activator nuclear factor kappa rankl receptor activator nuclear factor kappa ligand sam senescence accelerated mice sert serotonin transporter tlrs toll like receptors tph tryptophan hydroxylase tnf tumor necrosis factor ulcerative colitis
ability differentiate individuals group memberships individuation useful forming impressions social categorization fails method particularly valuable encountering incongruent social category conjunctions female bricklayer tested notion individuation initiated applying cognitively effortful explanatory emergent attributes incongruent conjunctions incongruent category conjunctions likely comprised emergent attributes individuation moderated application attributes experiment experiment individuation moderated emergent attribute application incongruent conjunctions cognitive load attenuated relationship allowing preventing generation attributes affect individuation incongruent conjunctions experiment ruled possibility emergent attributes cause increased individuation rule notion individuation precedes explanatory attributes together findings suggest individuating whose category memberships clash may applied effortful application explanatory emergent attributes
investigation vibration important topic purposes ride investigation control vibration important topic purposes ride comfort railway engineering vibration rail vehicles becomes complex affected condition vehicles including suspensions wheel profile condition track sections including rail profile rail irregularities cant curvature present study deals modeling control lateral rail vehicle active suspension pid controller numerical simulation dynamic behavior made based lagrangian approach order study effect vehicle speed response imperfections tracks model degrees freedom adopted consists one car body bogies wheel sets sperling ride index iso calculated using filtered rms accelerations order evaluate ride comfort allowing time evaluation dynamic behavior car body level passenger comfort analyzing accelerations center mass car body
study addresses applicability financial feasibility residential rainwater harvesting systems city austin texas cost benefit analysis used estimate financial return individual households rainwater harvesting systems addition subsidy value could provided delay wastewater treatment plant expansion project investigated findings suggest residential rainwater harvesting system would feasible without sufficient subsidy estimated subsidy also enough make cost harvesting system effective however multi purpose benefits quantified
controlling groundwater always great concern tunnel management tunnel drainage system may function properly due insufficient drain capacity drains become clogged sediment calcium carbonate study various types geocomposites investigated laboratory evaluate filtration discharge capacity characteristics potential use tunnels drain capacity geocomposites compared needle punched non woven geotextile currently used drain layer material tunnels based results discharge capacity tests performed four types geocomposites found meet filtration requirements presence calcium carbonate caco water found result decrease approximately maximum discharge capacity confining pressure kpa also maximum reduction observed discharge capacity approximately confining pressure increased kpa comparison geocomposites non woven needle punched geotextiles however revealed geocomposites significantly larger discharge capacity non woven needle punched geotextiles similar thickness approximate average times larger moreover discharge capacity geocomposites relatively less affected caco confining pressure compared non woven needle punched geotextile elsevier ltd rights reserved
activatable photosensitizers activated cancer associated stimuli drawn increasing attention simultaneous fluorescence imaging photodynamic ablation cancer cells developed cancer cell specific photosensitizer nano delivery system synthesizing protoporphyrin pplx conjugated pullulan reducible disulfide bonds amphiphilic ppix conjugate self assembled aqueous condition form core shell structured nanoparticles ppix nps average size showing reduction controllable stability vitro photoactivity sppix nps aqueous environment significantly suppressed self quenching effect kept ppix nps photo inactive quenched state presence gsh pix nps quickly dissociated reductive breakage disulfide linkers followed significant recovery fluorescent emission singlet oxygen generation mcf cells compared non reducible ppix nps stable amide linkages ppix nps displayed higher cytotoxicity induced higher apoptosis rate tumor cells light irradiation treatment result ppix nps may serve effective smart nanomedicine platform specific light reduction triggered cancer imaging photodynamic therapy prominently reduced damage normal tissues cells elsevier inc rights reserved
paper presents design results experimental platform aimed control air pressure inside small tank basic idea allow control algorithm select appropriate characteristic controller driving air compressor available set first approach goal make functional hardware circuits design software support inside integrated development environment high level programming language functional tests future work intended implement artificial intelligent based algorithms order exploit multicharacteristics features fuzzy decisions set selecting optimal control main parts controller industrial pressure sensor pic microcontroller microchip air pressure part consisting mainly car compressor small tank additional elements make operation safe solution microcontroller put operation parallel another one using industrial digital controller honeywell platform intended research activities dealing kind control algorithms implemented software associated pneumatic systems academic purpose joining unique structure sensors microelectronics interface techniques industrial controllers motors pneumatic elements software
nowadays significant increase noise become major problem urban areas using pervious concrete pavement recommended reduce noise unfortunately standard materials used produce pervious concrete completely environmental friendly result many researchers devoted attention towards identifying eco friendlier substitutions used manufacturing pervious concrete respect current paper discussed efficiency two different sizes oil palm kernel shell cockle shell partial replacement natural coarse aggregate sound absorption pervious concrete thirteen mixtures made replaced limestone shells specimens cured fog room void content compressive strength tested replacement natural aggregate decreased compressive strength although range still acceptable pervious concrete days however angular shape shells caused high void content maximum increase void content compared control pervious concrete cpc achieved use days moreover increasing sound absorption application shells particularly concrete could used silent road pavement therefore concluded use produce cleaner quitter pervious concrete pavement practical mechanically environmentally elsevier ltd rights reserved
purpose corporate social responsibility csr evolved important agenda many industries scope widened responsible business strategic decisions therefore purpose paper investigate concept csr perspective construction industry questioning csr awareness csr activities csr integration comparative case study turkey design methodology approach conducting comparative qualitative research using case study methodology study sets context understanding differences two countries csr perceived put practice selected case firms findings results revealed construction companies aware increasing importance csr however company scale characteristics country great impact csr preferences despite differences approaches firms take regard csr domains csr types ethical domain social orientation become prominent csr initiatives turkey originality value study provides empirical evidence understanding integration csr concept construction industry shed light missing knowledge csr integration serves source depth researches csr
research elder physical activity health emphasis predominantly centered outcome little attention given examination recruitment strategies effective article reports strategies methods used recruiting participants senior health physical exercise shape project randomized trial neighborhood walking multifaceted staged protocol computerized telephoning followed direct mail personal contact methods employed recruit representative sample elderly participants years female metropolitan neighborhoods portland significant variations distribution found conditions chi within walking condition chi indicating overall women men tended respond differentially different methods details evaluation recruitment strategies costs implications findings recruiting older adults community based physical activity programs discussed elsevier inc rights reserved
novel dispersive delay structure dds based composite right left handed crlh crlh coupler proposed demonstrated full wave experimental results experimental prototypes compact shielded multilayer ddss implemented low temperature fired ceramics technology compared conventional pass section dds proposed crlh section dds exhibit larger group delay swing leads higher resolution analog signal processing applications result higher coupling capability moreover feature larger bandwidth smaller size generalized wave interference analysis presented rigorously derive transfer functions group delay characteristics section ddss provide deeper insight operating mechanisms left right handed regimes
study attempts model spatio temporal dynamics total phosphate concentrations along river effective hydro environmental management propose systematical modeling scheme sms ingenious modeling process equipped dynamic neural network three refined statistical methods reliably predicting concentrations along river simultaneously two different types artificial neural network bpnn static neural network narx network dynamic neural network constructed modeling dynamic system dahan river taiwan used study case ten year seasonal water quality data collected seven monitoring stations along river used model training validation results demonstrate narx network suitably capture important dynamic features remarkably outperforms bpnn model sms effectively identify key input factors suitably overcome data scarcity significantly increase model reliability satisfactorily estimate site specific concentration seven monitoring stations simultaneously adequately reconstruct seasonal data monthly scale proposed sms reliably model dynamic spatio temporal water pollution variation river system missing hazardous costly data interest elsevier rights reserved
social categorical knowledge partially grounded proprioception study participants describing hard soft politicians hard soft scientists used different hard soft traits two groups suggesting meaning traits context specific studies showed meanings supported hard soft proprioception consistent political stereotypes perceivers viewing faces handling hard ball likely categorize republicans rather democrats compared perceivers viewing faces handling soft ball study similarly consistent stereotypes hard soft academic disciplines perceivers likely categorize photographs professors physicists historians handling hard versus soft ball study finally thinking republicans democrats led participants perceive ball harder softer respectively suggesting simulating proprioception might aid social categorical thinking study
objective considering higher rate oral cancer reduction salivary antioxidants smokers indicated previous studies antioxidant containing nutrients green tea seem beneficial counteracting oxidative stress group study assessed salivary total antioxidant alteration smokers compared nonsmokers short tem days long term weeks green tea drinking design experimental study volunteer moderate heavy male smokers matched healthy non smokers selected participate according inclusion criteria participants instructed drink two cups green tea per day dissolving green tea hot water cup saliva collection antioxidant capacity saliva measured baseline days days statistical evaluation done spss using paired samplet tests one way anova bonferroni tests results day zero nonsmokers higher antioxidant capacity smokers also significant difference two groups salivary total antioxidant capacity one week three weeks green tea consumption however upward trend smokers non smokers study period tea drinking addition significant difference found total antioxidant capacity alteration smokers compared non smokers baseline day conclusions results support effectiveness green tea consumption salivary antioxidants enhancement smokers short long term elsevier ltd rights reserved
study presents approach system identification adaptive control non inverting buck boost converter presence large signal changes uncertainty converter components effects imperfect modelling feedback loops converters typically designed conservatively closed loop regulation stability margins maintained pre determined range operating conditions proposed approach able keep high performance response without instability issue dynamic change converter presence uncertainty parameters converter digital adaptive controller based system identification minimum degree pole placement proposed verify validity proposed digital controller experimental setup constructed non inverting buck boost converter fully digital adaptive control implemented micro controller experimental results show capability adaptive controller different operating points
multifunctional nanocomposite huge potential cell imaging drug delivery improving therapeutic effect less side effects date diverse approaches demonstrated endow single nanostructure multifunctionality herein report synthesis application core shell nanoparticles composed upconversion nanoparticle ucnp core graphene oxide quantum dot goqd shell ucnp prepared applied imaging guided analyses upconversion luminescence goqd prepared employed promising drug delivery vehicles improve anti tumor therapy effect study unique properties ucnps goqds incorporated single nanostructure provide desirable functions cell imaging drug delivery addition hypocrellin loaded goqds photo dynamic therapy pdt commonly used chemotherapy drug photo sensitizer conjugated goqd interaction loaded pegylated ucnp without complicated synthetic process break structure applying core shell nanoparticles mit assay demonstrated ucnps goqd shell loaded could excellent candidates multifunctional agents cell imaging drug delivery cell therapy elsevier rights reserved
recent years field neuroimaging undergone dramatic development specifically importance clinicians researchers managing patients epilepsies new methods brain imaging search seizure producing abnormalities implemented older methods undergone additional refinement methodology predict seizure freedom cognitive outcome also rapidly progressed general image data processing methods different complicated even decade ago review identify recent developments neuroimaging aimed improved management epilepsy patients advances structural imaging diffusion imaging fmri structural functional connectivity hybrid imaging methods quantitative neuroimaging machine learning discussed also briefly summarize potential new developments may shape field neuroimaging near future may advance understanding epileptic networks source treatment resistant seizures also better define areas need treated order provide patients better long term outcomes
paper presents new version wheelchair wheelchair stair climbing ability wheelchair able climb single obstacles staircases thanks hybrid wheel leg locomotion unit triple wheels cluster architecture new concept presented work represents improvement respect previous versions different arrangement functional elements wheelchair performances terms stability regularity movement stair increased particular attention paid ensure regular comfortable motion user stair climbing operation reason cam mechanism introduced designed aim compensate oscillation generated wheelchair frame locomotion unit rotation design methodology cam profile presented moreover parametric analysis cam profile mechanism dimensions conducted aim find cam profile suitable dimensions performances terms pressure angle radius curvature elsevier ltd rights reserved
bullying peer victimization school serious concerns students parents teachers school officials around world article reviews risk factors associated bullying peer victimization school within context bronfenbrenner ecological framework review integrates empirical findings risk factors associated bullying peer victimization within context micro parent youth relationships inter parental violence relations peers school connectedness school environment meso teacher involvement exo exposure media violence neighborhood environment macro cultural norms beliefs religious affiliation chronosystem changes family structure levels theories explain relationships risk factors bullying behavior also included discuss efficacy current bullying prevention intervention programs followed directions future research elsevier ltd rights reserved
emerging technology photovoltaic concentrated solar power csp hybrid technology considered one research focuses currently solar energy field due various advantages compared alone csp alone technologies compared alone system csp hybrid system produce electricity better power quality compared csp alone system cost power production reduced overall generating efficiency also greatly improved component csp component hybrid system compactly hybridized topping spectral beam splitting sbs technologies development csp hybrid systems accelerated recent years increase maturity csp technologies paper presents exhaustive review state art csp hybrid technologies including non compact hybrid system topping hybrid system sbs hybrid system hybrid system combining sbs topping technologies recent progresses key technologies csp hybrid systems high temperature solar cells spectral beam filters high flux heat exchangers generally discussed research status hybrid system performance summarized literature provide global point view csp hybrid technology advantages limitations hybrid technology also concluded according literature reviewed
background persons living hiv aids plwh smoke higher rates adults experience hiv related nonhiv related adverse smoking consequences study conducted systematic review synthesize current knowledge sex differences smoking behaviors among plwh methods abstracts medline reviewed publications met review inclusion criteria reported data smoking behaviors plwh sex sufficient data available conduct meta analysis one smoking variable current smoking prevalence results across studies meta analytic prevalence current smoking among female plwh confidence interval male plwh meta analytic odds ratio analyses repeated studies prevalence current smoking significantly different female plwh compared male plwh meta analytic odds ratio studies reported data sex smoking variables quit attempts noncigarette tobacco product use results many variables mixed discussion unlike general population difference smoking prevalence female versus male plwh indicating hiv infection status associated greater relative increase smoking women men research needed areas smoking behavior plwh understand similarities differences sex provide best interventions reduce high smoking prevalence sexes
article present new kind controllable metamaterial electromagnetic structure may applied stealth design stealth technology future transmission coefficient electromagnetic wave single radar cross section rcs structure electrically controlled simulated characterized ghz structure constructed split ring resonators srrs metallic wire arrays including pin diodes pin diodes periodically inserted discontinuous control electrical continuity wires either state state depending voltage simulation test prove structure could absorb electroniagnelic incident wave reduced rcs inarkedly largest scope dbm around frequency wiley periodicals inc
vessel circular star shaped cross sections studied representing respectively dilated constricted cases endothelial cells smoothly line bulge lumen computational haemodynamics simulations carried idealised periodic arteriole sized vessels red blood cell tube hematocrit value simulation single red blood cell serves comparison purposes bulk motion red blood cells reproduces well known effects including presence cell free layer apparent shear thinning non newtonian rheology velocity flow field analysed lagrangian reference frame relative given red blood cell hence removing bulk coaxial motion highlighting instead complex secondary flow patterns aggregate formation becomes apparent continuously rearranging dynamic brought inter cellular fluid mechanics interactions deformability properties cells secondary flow field induces vacillating radial migration red blood cells different radial locations red blood cells express different residence times orientation shape shear stresses exerted flow vessel wall influenced motion red blood cells despite presence cell free layer spatial temporal variations wall shear stress patters observed especially circular vessel star shaped vessel bears considerable stress protruding endothelial cell crests stress vectors coaxially aligned bulging endothelial cells hence regularise transmission stresses vessel wall elsevier ltd rights reserved
cellular senescence state stable proliferation arrest cells senescence pathway many beneficial effects seen activated damaged stressed cells well embryonic development wound healing however persistence accumulation senescent cells various tissues also impair function implicated pathogenesis many age related diseases osteoarthritis severely debilitating chronic condition characterized progressive tissue remodeling loss joint function prevalent disease synovial joints increasing age primary risk factor profile inflammatory catabolic mediators present pathogenesis strikingly similar secretory profile observed classical senescent cells chondrocytes sole cell type present within articular cartilage exhibit increased levels various senescence markers senescence associated beta galactosidase sagal activity telomere attrition accumulation pinka suggests hypothesis senescence cells within joint tissues may play pathological role causation review discuss mechanisms senescent cells may predispose synovial joints development progression well touching upon various epigenetic alterations associated senescence
public sphere question value anthropology degree assessment unfortunate education anthropology prepares students wide variety careers communicate relevancy anthropology discipline needs renewed focus applied methods longer research primarily phd students undergraduates also need opportunities developing tangible skills attractive useful employers paper provides example collaborative anthropological research laboratory carl addresses need based utah state university carl engages undergraduates experiential learning research cognitive anthropological study campus gender roles students gain valuable experience suite methodological approaches valued applied sector contend carl serves example construct research group focuses educational needs undergraduates
purpose review aimed review invasive fungal infections complicating primary immunodeficiencies pid recent findings several pid predisposing fungal infections recently deciphered card deficiency selectively predisposes fungal infections including candidiasis aspergillosis deep dermatophytosis phaeohyphomycosis frequent central nervous system location especially candida infection patients heterozygous stat gainof function mutations mostly predisposed chronic mucocutaneous candidiasis may also display even though less frequently invasive fungal infections aspergillosis complicating stat deficiency also major concern patients lung cavities antifungal prophylaxis recommended first group patients previously well reported pid known predispose fungal infections genetic defects impairing ifn gamma axis predispose cryptococcosis dimorphic fungal infections summary patients developing invasive fungal infections including candidiasis aspergillosis cryptococcosis phaeohyphomy cosis pneumocystosis disseminated infections caused dimorphic fungi without known underlying risk factors explored immunogenetically order diagnose primary immunodeficiencies even absence previous infectious episodes
purpose study examine impact rewarding parenting styles kindergarteners cheating behavior participants young children enrolled one three public kindergartens sanlurfa province turkey ages ranged months mean age months participants randomly assigned reward control groups participant tested individually participants asked solve labyrinth puzzle without looking solution absence applicator research assistants reward group participants informed successfully solved puzzle would get lollipop findings revealed reward group exhibited significantly cheating behavior control group cheating behavior related parenting styles investigator concluded using rewards educational tool may increase children tendency cheat
herein investigate solar photothermal conversion performances nanofluids experimentally theoretically experiments nanofluids loaded beaker exposed solar radiation solar photothermal conversion efficiency performances nanofluids using different nanoparticle volume fractions solar intensities discussed experimental results show equilibrium temperature increases volume fraction solar intensity increase although extent variation photothermal conversion efficiency declines conditions furthermore theoretical analysis based rayleigh scattering approximation beer lambert law predict solar absorption efficiency discussed good agreement calculated absorption efficiency experimental solar photothermal conversion efficiency reported absorption efficiency increases exponentially increasing collector height volume fraction moreover optimization selection collector design direct absorption solar collectors without consideration temperature field particular scientific importance elsevier ltd rights reserved
objective aim study describe literature regarding impact psychosocial comorbidities working capacity aneurysmal subarachnoid hemorrhage asah design methods study review literature using pubmed cinahl pyschinfo google scholar results patients asah affected depression anxiety cognitive impairment posttraumatic stress disorder less likely return work although mixed results may due inconsistent inclusion adjustment demographic clinical variables shown associated return work differences instrumentation sample size conclusions working capacity asah likely affected poor psychosocial outcomes future research consider standardization demographic clinical data use standardized measurement tools consider interrelatedness psychosocial comorbidities
background aim assess influence long term treatment tumor necrosis factor alpha tnf inhibitors total cholesterol triglycerides low density lipoprotein ldl high density lipoprotein hdl atherogenic index rheumatoid arthritis psoriatic arthritis psa ankylosing spondylitis patients methods retrospective cohort study conducted psa patients treated tnf inhibitors least days levels ldl hdl compared baseline values months patients subdivided three groups according hmg coa reductase inhibitor statin treatment status order assess effect results results records patients psa reviewed increased following treatment tnf inhibitors baseline months respectively months respectively increased following treatment tnf inhibitors baseline months ldl decreased significantly patients treated statins entire study period baseline months contrast increase ldl values patients receive statins study conclusions tnf inhibitor treatment associated significant increase levels adding statins treatment associated significant decrease ldl levels
paper propose high performance matrix inversion implementation reconfigurable application specific processor implementation accelerate variable order matrix inversion ranging adopt decomposition reduce computation complexity pivoting operation ensure stability order get higher performance within limited resources parallel computing time sharing multiplexing employed chip testing results show implementation improve performance inversion efficiently highest parallel speed ratio achieve times execution time matrix inversion
ergodic semi markov process structure represented full graph loops simulates digital control algorithm generated transactions onto object investigated elementary simplifications reduction semi markov processes defined recursive procedure reduction initial semi markov process structure till model includes selected states links proposed formulae recalculation probabilities weighted densities expectations time switching linked states obtained shown recursive procedure may used also calculation time expectation return process one selected states simplified task evaluation time intervals transactions polling procedure
modifiable areal unit problem ecological fallacy known problems occur modelling multiscale spatial processes investigate forms spatial aggregation error guide regionalization spatial domain interest regionalization mean specification geographies define spatial support areal data topic studied vigorously geographers given less attention spatial statisticians thus propose criterion spatial aggregation error minimize obtain optimal regionalization define criterion draw connection spatial aggregation error new multiscale representation karhunen loeve expansion relationship criterion spatial aggregation error multiscale karhunen loeve expansion leads illuminating theoretical developments including connections spatial aggregation error squared prediction error spatial variance novel extension obled creutin eigenfunctions effectiveness approach demonstrated analysis two data sets one using american community survey one related environmental ocean winds
although bariatric surgery fosters heightened excess weight loss values nutritional deficiencies prominent one common iron deficiency anemia purpose elucidate frequency anemia roux gastric bypass sleeve gastrectomy subjects retrospective analysis conducted subjects diagnosed type diabetes randomized sleeve gastrectomy roux gastric bypass intensive medical therapy anemia common female subjects underwent sleeve gastrectomy roughly half developed microcytosis months thereafter etiology anemia appears iron related precipitated female sex scant iron supplementation likely causative however anemia chronic inflammation discounted somewhat causal subsequently aggregate may synergistic influence
plasmonic silver nanoparticles varied shapes sizes agnps synthesized via facile one pot chemical reduction method investigated applicability dye sensitized solar cells dsscs synthesized agnps exhibit broadband absorption entire visible region owing unique localized surface plasmon resonance lspr photon conversion efficiency pce dsscs increased similar incorporating similar agnps similar ttm thin reference photoanode enhancement mainly due increase light harvesting ability plasmonic photoanode result local electromagnetic field enhancement strong near field scattering effect agnps addition reduction charge transfer resistance value confirms high charge carrier generation plasmonic dsscs elsevier rights reserved
establishing research strategy suitable undertaking research software engineering vital guarantee research products developed validated following systematic coherent method took account carried competisoft research project investigated software process improvement spi context latin american small companies experience enabled develop research strategy based integrated use action research case study methods paper introduces proposed research strategy provides extensive discussion application developing methodological framework competisoft spi putting framework practice eight small software companies refine methodological framework due practice feedback use research strategy allowed observe suitable developing refining improving applying validating competisoft methodology framework furthermore seen applied believe strategy offers successful integration action research case study useful conducting research software engineering areas address needs small software companies
mapreduce programming system distributed processing large scale data efficient fault tolerant manner private public hybrid cloud mapreduce extensively used daily around world efficient distributed computation tool large class problems search clustering log analysis different types join operations matrix multiplication pattern matching analysis social networks security privacy data mapreduce computations essential concerns mapreduce computation executed public hybrid clouds order execute mapreduce job public hybrid clouds authentication mappers reducers confidentiality data computations integrity data computations correctness freshness outputs required satisfying requirements shields operation several types attacks data mapreduce computations paper investigate discuss security privacy challenges requirements considering variety adversarial capabilities characteristics scope mapreduce also provide review existing security privacy protocols mapreduce discuss overhead issues elsevier inc rights reserved
green roof systems suggested ease growing urban environmental problems resulting rapid urbanization however irrigation green roofs heavily depends using precious potable water consequently generates negative environmental effects rainwater recommended address dilemma design method well developed study major design factors rainwater harvesting system green roof irrigation systems examined simulation based mathematical model established elucidate correlation tank volume system performance optimal system design probability distribution potable water replacement rate also discussed basis case study university building keelung northern taiwan results show optimal tank volume potable water replacement rate probability exceedance respectively addition economic performance identified feasible hence design method verified useful tool ease urban environmental issues
three single stage absorption heat transformer ssht configurations modeled analyzed compared viewpoints thermodynamics economics using engineering equation solver ees software addition multi objective optimization carried three configurations specify optimal design point considering second law efficiency product unit cost two objective functions configurations differ one another considering number heat exchangers used results show coefficient performance cop exergy coefficient performance ecop configuration around higher corresponding values configuration respectively also configuration found economic product unit cost lower configurations respectively furthermore observed relatively higher absorber temperatures achieved configurations compared configuration concluded multi objective optimization conditions evaporator condenser absorber temperatures degrees degrees degrees respectively represents optimal solution
aim work study effect localized impact wall made soil reinforced geocells first two structures tested impacting remote controlled car experiments carried scale model structures practical reasons designed mimic mechanical response alveolar geocell reinforcement system two types constitutive materials considered geocells different mechanical properties test structures dismantled tests analyse influence impact cell layers especially within bulk examining video tests captured two high speed cameras also helped understanding phenomena occurred impact experiments completed numerical simulations whose objective understand clearly causes phenomena observed either within dismantled structures videos elsevier ltd rights reserved
existing theories acculturative stress theory adequately explain mental disorders immigrants less prevalent non immigrants paper culture gene evolutionary theory mental disorders utilized generate novel hypothesis connection heritage culture reduces risk mental disorders immigrant children four groups children aged years identified united states national survey children health generation immigrant children generation immigrant children foreign adoptees non immigrant children generation immigrant children connection heritage culture stronger similar generation immigrants foreign adoptees little connection birth culture controlling age sex family type ses odds add adhd conduct disorder anxiety disorder depression diagnosis lowest generation immigrant children followed generation immigrant children foreign adoptees foreign adoptees non adopted children similar odds disorders connection heritage culture might underlying mechanism explained recent immigrants lower rates mental disorders
past three decades exponential increase worldwide availability internet access devices able access online materials literature review investigated whether increased accessibility internet child pornography increases risk person child sexual exploitation current review found little evidence availability internet increased worldwide incidence prevalence person child sexual abuse fact time period internet flourished international crime statistics shown steady decrease person child sexual abuse exception trend increase internet child pornography luring offenses stats involves child abuse definition article reviews impact internet child sexual abuse also reviews characteristics online offenders treatment offenders prevention offenses also discussed
paternal postpartum depression ppd within first postpartum year estimated occur new fathers paternal ppd occurs later postpartum men women results father infant bonding issues may lead long term effects child detrimental effects couple relationship risk factors paternal ppd include mother ppd father history depression unmarried recent evidence suggests paternal ppd may related sensitivity low testosterone men childbirth professionals opportunity raise awareness issue pre postnatal education parents
special diets consumed treatment diseases food allergies diabetes lactose intolerance coeliac disease lifestyle related diets vegetarian weight reducing sports bodybuilding low carbohydrate diets also called special diets aim study examine frequency reasons special diet consumption therapeutic measure lifestyle related choice among year old finns nationwide cross sectional data collected mailed self administered questionnaires number respondents varied response rates ranged consumption special diets therapeutic purposes lifestyle related choice showed significant increasing trend year olds study period frequently reported single diets adolescents vegetarian lactose intolerance diets however fluctuation trend observed consumption different lifestyle related diets growing number respondents especially girls reported simultaneous consumption combination two therapeutic lifestyle related diets reason choosing therapeutic diet seems stay constant studied period contrast wide variety reasons health wellbeing body weight ethical ideological reasons avoidance specific foods given consumption lifestyle related diets study results correspond well increased prevalence common illnesses finland data also reveal properties special diet consumption among adolescents long run highlights need educate finnish adolescents nutrition literacy
background recently reported antipsychotic treatment reverted contactin associated protein like caspr cntnap mrna expressions leukocytes schizophrenia scz subjects levels healthy controls caspr expressed various regions mice brain cortex frontal lobes corpus callosum hippocampus etc thus study evaluated caspr mrna expression scz subjects find new clue schizophrenia pathogenesis methods one hundred scz subjects age matched controls compared levels caspr mrna leukocytes analysed quantitative real time pcr method using taqman probes results caspr mrna expression significantly higher leukocytes scz subjects controls however significant correlations expression level clinical parameters scz subjects conclusion considering caspr involved building brain neural network autophagy circulating leukocytes abnormal caspr expression scz subjects may associated pathogenesis scz
mccune albright syndrome mas triad cafe lait skin pigmentation precocious puberty polyostotic fibrous dysplasia bone general seems common component mas rarely precocious puberty found association cafe lait skin pigmentation absence cases therefore clinically relevant definition mas fibrous dysplasia bone least one typical hyperfunctioning endocrinopathy cafe lait spots almost combination possible bone scan modality choice look bone disease burden fibrous dysplasia patients mas may change management accordingly cases mas reported worldwide associated hyperthyroidism best knowledge basis literature search pubmed google case reported hypothyroidism herein report year old girl diagnosed mas associated hypothyroidism also reviewed mas related literature
background schizophrenia suggested complex polygenetic disorder high heritability genome wide association studies found polymorphisms associated han chinese however results validation studies inconsistent study aimed test association nkapl tspan mpc polymorphisms chinese population methods study contained unrelated patients zhuang han gender age matched controls zhuang han polymorphisms tspan nkapl mpc genotyped using sequenom massarray method statistical analyses performed plink program spss windows stata used meta analysis results statistically significant difference found different allele genotype frequencies cases controls zhuang han ethnicities total samples meta analysis suggested single nucleotide polymorphism significantly associated han chinese population conclusions case control study failed validate significant association nkapl tspan mpc polymorphisms susceptibility southern zhuang han chinese population however meta analysis showed significant association mpc variant susceptibility han chinese
modern design long suspension bridges must satisfy time spanning long distances limiting response several external loads even high intensity structural control solutions provides offer reliable contribution limit internal forces deformations structural elements extreme events occur positive aspect interesting dimensions structure large herein updated numerical model existing suspension bridge developed commercial finite element work frame starting original data model used reevaluate optimization procedure passive control strategy already proven effective simplified model buffeting wind forces optimization procedure previously implemented quasi steady model buffeting excitation reevaluated adopting refined version wind structure interaction forces wind actions applied towers cables considering drag forces deck refined formulation based use indicial functions adopted reflect coupling bridge orientation motion shown variation previously identified optimal passive configuration
harvesting rainwater common practice worldwide particularly areas access public water supply insufficient groundwater reserves two million people living semiarid regions brazil consume rainwater stored cisterns little information available regarding water quality despite initial good quality rainwater harvest storage introduce contaminants must eliminated consumption evaluate influence handling cistern age precipitation quality harvested rainwater monitored seven cisterns semiarid brazilian northeast years microbial physicochemical parameters monitored month denaturant gradient gel electrophoresis dgge performed end monitoring period coliform bacteria detected samples escherichia coli observed alkalinity conductivity highest recently built cisterns due dissolution construction materials dgge dna reveal presence coli instead dgge bands sequencing indicated species primarily affiliated alphaproteobacteria present cisterns indicating presence microbial ecosystems capable purifying stabilizing stored rainwater
recognized veterans increased rates depression post traumatic stress disorder ptsd suicide substance use disorders rates homicide unintentional injury deaths veterans minimally investigated evaluated non natural deaths new mexico veterans comparison non natural deaths among non veterans reviewed decedents new mexico history military service investigated medical examiner excluding natural deaths deaths due fall standing height common manner death unintentional injury deaths due motor vehicle accidents followed unintentional overdose suicide rates among veterans consistently higher general population common mechanism suicide men gunshot wound intentional overdose women services needed veterans tailored ages sexes
covert channels provide means conceal information transfer hosts bypass security barriers communication networks hidden communication paramount concern governments companies conceal data leakage malware communication crucial building blocks used cyber crime propose detectors based descriptive analytics traffic dat facilitate revealing network transport layer covert channels originated wide spectrum published data hiding techniques dat detectors transform communication data flexible feature vectors represent traffic set extracted calculations estimations case covert channels core detection performed combined application autocorrelation calculations multimodality measures built upon kernel density estimations pareto charts dat detectors devised embedded extensions network intrusion detection systems able perform fast lightweight analysis numerous flows present paper focuses specifically tcp traffic provides suitable classifications tcp fields related covert channel techniques perspective statistical detection proposed methodology evaluated public traffic datasets well covert channels generated according main techniques described related literature copyright john wiley sons ltd
since refineries petrochemical plants connected mexican grid number magnitude failures electrical generators increased constant starts stops grounding schemes used plants important factors typical cases failure reported last years described paper
since pair programming appeared literature effective method teaching computer programming many systems developed cover application pair programming distance today systems serve personal professional educational purposes allowing distributed teams work together programming project current research focuses distributed pair programming systems suitable supporting students learning computer programming systematic review publicly available systems revealed absence effective collaboration support students main drawbacks pair programming uneven workload distribution infrequent role switches addressed available systems building enhanced version distributed pair programming system successful instructional strategies similar collaborative learning systems explored order improve students interactions applying pair programming distance result new system allows students practice distributed pair programming form collaboration scripts paper presents features underlying concepts system results first evaluation study showed distributed pair programming attracted positive feedback students scripted collaboration affected students engagement programming resulted evenly distribution learning objectives among pairs
computer simulation basic tool future power engineering education allows better understanding various electrical phenomena without need make contact real system achievement use simulators contribute improvement electricity supply security taking account basic idea one utmost important factors electric power field quality education training specialists connecting disconnecting electrical circuits using circuit breakers voltages currents occur differ stationary quasi permanent regimes generating high stress working conditions electrical appliances present application made simulate short circuit current transient recovery voltage certain simplifying conditions flash code action script programming language used completion simulator software items exhibited paper highlight real solution achieve suitable interface graphic analysis dynamic phenomena electric networks application meant improve electric engineering education modern simulation methods
introduction second hand smoke exposure shs children remains major pollution problem important consequences children health study aimed identify sources exposure shs among year old children comparing self reports urinary biomarker exposure characterize important variables related shs exposure population methods year old children exposure shs assessed parental reported questionnaire urinary cotinine measurements participants different areas spanish inma infancia medio ambiente environment childhood project questionnaire shs included information smoking habits home household members exposure shs places including homes bars restaurants transportation association quantified levels sociodemographic variables different sources shs exposure examined using logistic regression results based parental reports children exposed shs home elsewhere making total children exposed shs addition children whose parents reported regularly exposed shs quantified values children younger mothers higher odds exposure shs per year well families lower educational level secondary primary less odds quantifiable children dropped smoking ban public places regarding sources shs exposure observed quantifiable odds increased children whose parents smoked home presence mother occasionally mother often father occasionally father often children attending confined places mainly houses people smoked conclusions children shs exposure nowadays unresolved major public health problem spain ban smoking public places health care professionals put emphasis parents importance controlling exposure children private spaces elsevier inc rights reserved
internet security problems still big challenge many security events occurred internet worms spam phishing attacks etc botnet well organized distributed network attack consists large volume bots generates huge volumes spam launching distributed denial service ddos attacks victim hosts address problems practical collaborative network security management system proposed well deployed collaborative utm unified threat management traffic probers paper propose design implementation cloud based security center network security forensic scrutiny propose use cloud storage keep collected traffic data processing cloud computing platform find malicious attacks workable case phishing attack forensic analysis presented required computing storage resources evaluated based real trace data
introduction article part focus theme methods information medicine pervasive intelligent technologies health background effective nonverbal communication patients clinicians fosters delivery empathic patient centered care positive patient outcomes although nonverbal skill training recognized need efforts enhance patient clinician communication provide visual feedback nonverbal aspects clinical encounter objectives describe novel approach uses social signal processing technology ssp capture nonverbal cues real time display ambient visual feedback control affiliation two primary yet distinct dimensions interpersonal nonverbal communication examine design clinician acceptance ambient visual feedback nonverbal communication formulated model relational communication ground ssp conducted formative user study using mixed methods explore design visual feedback methods based model relational communication reviewed interpersonal communication research map nonverbal cues signals affiliation control evidenced patient clinician interaction corresponding formulation theoretical framework designed ambient real time visualizations reflect variations affiliation control explore clinicians acceptance visual feedback conducted lab study using wizard technique simulate system use healthcare professionals followed seven participants interviews iterate design revised visualization addressed emergent design considerations results ambient visual feedback nonverbal communication provides theoretically grounded acceptable way provide clinicians awareness nonverbal communication style provide implications design visual feedback encourages empathic patient centered communication include considerations metaphor color size position timing feedback conclusions ambient visual feedback ssp holds promise acceptable means facilitating empathic patient centered nonverbal communication
synthesis characterisation partially substituted calix jarene namely tetra tertbuty bis aminoethoxy dihydroxycalix arene reported interaction commonly used pharmaceuticals clofibric acid diclofenac aspirin investigated spectroscopic nmr electrochemical conductance measurements thermal titration calorimetry techniques concluded basis experimental work molecular simulation studies receptor interacts selectively drugs preliminary studies selective extraction pharmaceuticals water calix receptor reported potential carrier mediated sensor based ligand site monitoring pharmaceuticals discussed elsevier rights reserved
quantitative measurements local fuel concentrations conducted direct injection hydrogen spark ignition research engine using spark induced breakdown spectroscopy sibs technique sibs measurements new sensor developed commercially available type spark plug major modifications electrodes new plug sensor showed better durability required less maintenance used hydrogen research engine emission spectra plasma generated spark plug collected optical fibre housed centre electrode plug resolved spectrally atomic emissions main focus present work characterise effects ambient pressure ignition timing spectral line emissions improve accuracy sibs measurements taking account pressure dependency atomic emissions significant effect corresponding pressure ignition timing observed spark induced breakdown spectroscopic measurements emission line characteristics retarded spark timing higher ambient pressure ignition site resulted lower spectral line intensities well weaker background emissions well established relatively higher pressure density atoms molecules cooling expanding plasma accelerates collision probability increases leading weaker broadband continuum atomic emissions calibration map representing correlation air excess ratio relative air fuel ratio intensity ratio pressure ignition timing created subsequently used quantitative measurements local fuel concentrations port injection direct injection strategies demonstrate explore effects pressure dependency atomic emission accuracy sibs measurements local stratification fuel mixture vicinity spark gap location associated direct injection strategies confirmed coefficient variation local air excess ratio relatively small measurements made using calibration map demonstrated measurement accuracy local fuel concentrations spark plug sensor improved significantly pressure dependency atomic emissions taken account hydrogen energy publications llc published elsevier ltd rights reserved
objectives whether smoking increases risk postoperative pulmonary complications ppcs lung resection patients remains controversial objective study evaluate whether active smoking time surgery increases risk ppcs compared abstention shortly procedure methods conducted case control study patients underwent non extended lobectomy institution cases active smokers time surgery controls patients quit smoking time weeks surgery patients received perioperative care including chest physiotherapy occurrence ppcs considered outcome ppcs defined pneumonia american thoracic society criteria atelectasis requiring bronchoscopy cases controls matched according age body mass index forced expiratory volume first second expiration fev fev forced vital capacity type approach diagnosis non small cell lung cancer calculated odds ratio confidence interval ppcs results overall prevalence ppcs active smokers group smokers group matching two sets patients compared prevalence active smokers conclusions population patients strictly matched according risk criteria ppcs smoking time surgery identified risk variable therefore practice postponing surgery tobacco abstention achieved seem justified
process mining emerging discipline whose aim discover monitor improve real processes extracting knowledge event logs representing actual process executions given organizational setting light applied faithful event logs adhering accepted standards xes available many real world settings though event logs explicitly given instead implicitly represented inside legacy information systems organizations typically managed relational technology work devise novel framework supports domain experts extraction xes event log information legacy relational databases consequently enables application standard process mining tools data differently previous work extraction driven conceptual representation domain interest terms ontology one hand ontology linked underlying legacy data leveraging well established ontology based data access obda paradigm hand framework allows one enrich ontology user oriented log extraction annotations flexibly used provide different log oriented views data different data access modes devised view legacy data lens xes
rationale preeclampsia reflects unusual increase systemic inflammation pregnancy objectives studied associations preeclampsia asthma allergy eczema copenhagen prospective studies asthma childhood copsac national registries methods copsac high risk birth cohort danish children asthma allergy eczema diagnosed prospectively lung function measured age month years sensitization evaluated age months months years years skin prick tests ige measurements register based cohort included million children danish national registries year period children born mothers preeclampsia analyzed regarding risk asthma allergy eczema measurements main results copsac cohort diagnosed preeclampsia preeclampsia associated increased risk treatment inhaled corticosteroids age years adjusted odds ratio confidence interval increased bronchial responsiveness methacholine adjusted beta coefficient log mol allergic rhinitis adjusted odds ratio year old children furthermore children increased risk sensitization aeroallergens food allergens increased amount total ige childhood registry based cohort born mothers preeclampsia preeclampsia associated increased risk asthma eczema aeroallergen food allergy especially pronounced duration preeclampsia days maternal asthma increased risk preeclampsia conclusions preeclampsia shared prenatal risk factor asthma eczema allergy childhood pointing toward utero immune programming child
vigorous increase frequency water pollution become serious bottlenecks constraining national economy modern industry development therefore research control treatment water contaminants great significance urgency zeolitic imidazolate frameworks zifs product chemical material science rapidly developing recent years received extensive attention around world applied waste water treatment owing stable structure high surface area excellent performance taking zif representative paper reviews research development application zifs remove water contaminants performance zifs removal water contaminants adsorbent photocatalyst introduced systematically factors influencing water contaminants removal zifs summed moreover carried forecast later period research objective paper provide theoretical reference practical application zifs treatment real waste water
stress episodic memory impairment previously associated acute stress disorder asd maladaptive stress response develops individuals following traumatic life events recently authors demonstrated specific deficit associative memory emotionally neutral stimuli asd posttraumatic stress disorder ptsd study tested relationship memory impairment course asd assessed new learning memory item associative information patients diagnosed asd matched trauma naive controls memory performance posttraumatic symptoms examined approximately week periods following traumatic experience two experiments participants studied list stimuli pairs verbal visual tested memory items item recognition test association items pair associative recognition test experiments asd patients showed marked associative memory deficit compared control group weeks asd symptoms resolved patients interestingly performance associative recognition verbal stimuli improved associative deficit visual stimuli remained unchanged potential mechanisms underlying associative memory deficit posttrauma patients discussed elsevier ireland ltd rights reserved
way emotion represented processed human brain expanding area research key implications understand potentially treat affective disorders depression characterizing effects pharmacological manipulations key neurotransmitter systems also help reveal neurochemical underpinnings emotional processing common antidepressant drugs may work treatment depression anxiety approach revealed depression associated neural behavioural biases towards negative positive stimuli evidence pharmacological challenge studies suggests antidepressant treatment acts normalize biases early treatment resulting patients experiencing world positive way improving mood time model supported evidence pharmacological non pharmacological interventions unique perspective antidepressant treatment offered approach provides insights individual response treatment well novel approaches drug development
purpose purpose paper deal design passive filter power electronics voltage inverters used aircraft electrical drives permanent magnet synchronous machine fed six phase voltage inverter pmw control using optimization sizing sensibility analyses design methodology approach approach generic aid allows modify easily frequency model check various study cases carry filter optimization different topologies control strategies findings approach generic aid allows modify easily frequency model check various study cases carry filter optimization different topologies control strategies research limitations implications power electronics load supposed set predefined harmonic sources obtained experiment time simulation plus fast fourier transformation optimization process practical implications problem numerous constraints components mainly technological constraints volume minimized respecting electromagnetic standards electro magnetic interference filter prototype made originality value frequency model automatically generated complex aircraft application studied thanks approach several sensibility analyses carried emc filter sized experimental prototype made comforting sizing optimization
article problems use common winch cart steep terrain planted permanent crops described especially regard energy losses hypothesis developed regarding improved use potential energy leads development new economical hydraulic machine transmission new agricultural tractor use much bigger share effective potential energy conceived rough principles portable flatbed improves total efficiency comparable analysis different sloped terrains presented argue greater efficiency new machine yearly fuel quantity saving using new hydraulic machine sloping terrain realistic topography comparison winch cart decisional limits minimum internal combustion engine power discussed
development process complex production machines requires intense collaboration different technical disciplines context interdisciplinary development team often lacks common continuously updated system model machine consequently lead high communication effort delays overall development process efficient effective production machine design process interdisciplinary modeling language required follows generic design approach therefore analyzed existing modeling languages identified drawbacks concerning application machine design based findings developed interdisciplinary modeling language iml combining benefits existing languages extensions iml includes three diagram types functional structure interaction structure sequential behavior diagram sbd furthermore propose diagrams integrated general machine development process demonstrate utilization imi basis use case
purpose psychosocial risk factors high rates psychiatric comorbidity render individuals autism spectrum disorders asd vulnerable developing low self esteem lse cognitive behaviour therapy cbt interventions effective enhancing self esteem typically developing populations degree clinically beneficial individuals asd little explored paper aims discuss issues design methodology approach pilot group intervention undertaken investigate effectiveness acceptability cbt lse adults asd adaptations standard protocols made order accommodate core asd characteristics findings four participants attended eight sessions comprised formulation causal maintaining mechanisms lse cognitive interventions designed reduce self criticism promote balanced self view behavioural interventions intended increase engagement enjoyable activities enhance problem solving skills assertiveness self report questionnaires completed four time points baseline first last sessions one month follow data analysis indicated change primary self esteem outcome measure improvements noted secondary outcomes specifically social anxiety depressive symptoms general functioning research limitations implications studies needed determine design deliver cbt interventions techniques target lse individuals asd originality value one first cbt group interventions designed address lse adults asd
structural damage detection diagnosis important factor structural safety wavelet transform combined artificial immune algorithm used improving application artificial intelligence algorithms structural damage detection result simulation verification analyzing suspension bridge structure suggest approach combines advantages wavelet analysis artificial immune algorithm quickly accurately identifying damage location calculating extent damage method used engineering practice structural damage detection improve efficiency structural damage identification
common materials used orthopedic implants titanium alloys improve compatibility environment living organism titanium implant surfaces covered bioactive layers mwcnt insertion living organism material exposed direct contact patient blood includes proteins albumin adsorption albumin may constitute one early stages implant surface modification serving cell adhesion analysis phenomenon terms kinetics deposition protein surface implant confirms biocompatibility vivo proposed working model adsorption albumin allows choosing best time protein form stable connection surface titanium implant traditional methods materials engineering chemistry allow obtaining information presence protein surface vis wettability application correlation analysis turn gains insight dynamics changes associated deposition protein formation uniform layer change conformation analysis allowed selection optimal time protein adsorption surface implant better compatibility body implant provides modification introducing layers accelerate material tissue interactions composition layer carbon nanotubes mwcnts deposited titanium electrophoretic epd method using raman spectroscopy analyzing spectra correlation method possible gain insight molecular structure layer studies indicate albumin contact surface titanium obtained stable conformation min confirmed vis raman shifts stretching bands position well analysis amide band confirms conformation dynamics changes noticed correlation peaks observed maps elsevier rights reserved
epidemiological studies based hygiene hypothesis declare level childhood exposure environmental microbial products inversely related incidence allergic diseases later life multiple types immune cell mediated immune regulation networks support hygiene hypothesis epithelial cells first line response microbial products environment bridge innate adaptive immune systems however role hygiene hypothesis unknown demonstrate hygiene hypothesis airway epithelial cells examined effect lipopolysaccharide lps toll like receptor ligand expression proallergic cytokines thymic stromal lymphopoietin tslp interleukin cells pulmonary mucoepidermoid carcinoma cells stimulation tlr ligand polyi human parechovirus type hpev lps induced tslp interferon regulatory factor irf kappa activity validated using inhibitors dexamethasone bay short hairpin rna mediated gene knockdown importantly polyi hpev stimulated tslp induction reduced lps treatment attenuating tank binding kinase irf kappa activation interestingly basal mrna levels tlr signaling proteins downregulated long term lps treatment cells suggests long term exposure modulates expression innate immunity signaling molecules airway epithelial cells mitigate allergic response contrast effects lps treatment alarmin high mobility group protein acts synergy polyi promote tslp expression data support part hygiene hypothesis airway epithelia cells vitro addition therapeutic targeting tslp local application non pathogenic lps may rational strategy prevent allergies
psoriatic arthritis psa heterogeneous disease involve variety distinct anatomical sites including patient peripheral axial joints entheses skin nails appropriate management psa requires early diagnosis monitoring disease activity utilization cutting edge therapies accomplish former variety psa specific tools available screen diagnose assess patients review outline recently developed psa screening tools including toronto psoriatic arthritis screening questionnaire topas psoriasis epidemiology screening tool pest psoriatic arthritis screening evaluation pase psoriasis arthritis screening questionnaire pasq also review classification criteria psoriatic arthritis caspar current psa disease severity measures disease activity index psoriatic arthritis dapsa psoriatic arthritis joint activity index psajai composite psoriatic disease activity index cpdai case psa screening assessment tools also variety new therapies available psa historically patients psa treated nsaids traditional disease modifying anti rheumatic drugs dmards however ability medications slow radiographic progression joint disease demonstrated contrast anti tnf agents etanercept infliximab adalimumab golimumab certolizumab effective regard emerging psa treatments include oral phosphodiesterase inhibitor apremilast janus kinase jak inhibitor tofacitinib several new biologics target pathway including secukinumab brodalumab ixekizumab ustekinumab herein review mechanisms action drugs results clinical trials guidelines administration lastly treatment recommendations european league rheumatism eular group research assessment psoriasis psoriatic arthritis grappa discussed published elsevier ltd
micro energy grids many merits promising applications smart grid vision demanding procedures optimal planning performance enhancement one key features micro energy grid ability separate isolate main electrical network continue feeding islanded portion paper optimal sizing operation strategy micro energy grids equipped renewable non renewable based distributed generation storage presented general optimization objective define best mix energy storage units self sufficient micro energy grids multi objective genetic algorithm applied solve planning problem minimum optimization goal overall cost including investment cost operation maintenance cost fuel cost carbon dioxide emission constraints include power heat demands constraints dgs capacity limits candidate technologies include chps combined heat power different characteristics boilers thermal electrical storages renewable generators wind photovoltaic order assess different configuration options components sizes several case studies typical micro energy grid presented
brain food tryptophan antioxidative substances vitamins magnesium thought beneficial obesity inflammation insulin resistance present pilot study hypothesised specific amino acid mixture micronutrients improves cardiometabolic situation chronically stressed persons cardiovascular metabolic parameters analysed per protocol patients chronic stress disorders patients assessed psychological neurological questionnaire pnf dietary intervention reduction fasting serum insulin concentrations occurred treatment group association found pnf values insulin concentrations baseline insulin reduction weeks results support use specific dietary supplement improved stress management decrease metabolic dysfunction
introduction acute hepatitis acute inflammation liver elicited large number causes sometimes spontaneously recovers sometimes may progress chronic hepatitis liverfatty acid binding protein fabp small protein abundant hepatocytes binds longchain fatty acids present cytosol aim present study aimed investigate levels serum urine fabp acute hepatitis diagnostic value serum urine fabp levels patients acute hepatitis materials methods present study included total patients total number patients acute hepatitis five acute hepatitis one acute hepatitis two acute hepatitis five autoimmune hepatitis four toxic hepatitis hepatic encephalopathy liver cirrhosis controls included serum urinary fabp levels analyzed enzyme linked immunosorbent assay elisa results serum fabp levels patients acute hepatitis hepatic encephalopathy cirrhosis control subjects respectively statistically significant positive correlations serum levels fabp aspartate aminotransferases ast alanine aminotransferases alt creatinine cre gamma glutamyl transferases ggt respectively cut value serum fabp patients area curve auc sensitivity specificity respectively positive negative predictive values serum fabp respectively conclusion serum urine fabp may new diagnostic marker liver damage patients acute hepatitis however study showed except aminotransferases fabp used diagnosis liver damage patients acute hepatitis chronic hepatitis also cirrhosis
electromagnetic actuators widely used industry due simple structure force characteristics low manufacturing costs however control point view nonlinear systems brief clustering based system identification experiments well piecewise mathematical model described furthermore model based fault detection isolation actuator presented armature movement sensed indirectly sensing armature current
steganography technique dissimulating information digital media contrast cryptography keep non intended recipients knowing hidden information keep secret even existence hidden information paper propose new image steganography method based haar discrete wavelet transform data hidden frequency domain since robust area embedding performed integer part coefficients transform prevent loss data coming floating point way increases imperceptibility capacity hiding test performance proposed method experiments variety images accomplished results show better image quality high imperceptibility payload comparison prior works security strengthened using random key chooses randomly location hide data
rainwater harvesting small dams good potential provide supplementary agricultural irrigation critical crop growth stages field experiments conducted evaluate cropping patterns fallow wheat mash wheat maw sorghum wheat maize grain wheat maize grain gram mung canola muc two conditions irrigated command area pira fatehial small dam rainfed command area sandy loam soil three years treatments arranged randomized complete block design three factor factorial cropping patterns irrigated non irrigated conditions years using four replications highest grain yield wheat mgha obtained maw cropping pattern compared cropping patterns summer crops sorghum fodder maize grain mash performed excellent irrigated conditions water use efficiency wheat kgha following mash conditions exhibited higher values compared cropping patterns however nutrient use efficiency cropping pattern surpassed others performance crops remained better irrigated condition seasons years rainfall deficiency compensated supplementary irrigations hence study concluded farmers water resources supplemental irrigation adopt cropping pattern based grain yield efficient utilization available supplemental water better utilization nutrients similarly based improved nutrient utilization monitory outputs maw sequence followed rain fed areas better resource management copyright john wiley sons ltd
background lower urinary tract symptoms highly prevalent large proportion symptoms known associated dysfunction afferent pathways diagnostic tools objective reproducible assessment afferent nerve function lower urinary tract missing previous studies showed first feasibility results sensory evoked potential recordings following electrical stimulation lower urinary tract healthy subjects patients nevertheless refinement methodology necessary methods study prospective randomized trial conducted balgrist university hospital zurich switzerland ninety healthy subjects forty females fifty males without lower urinary tract symptoms planned included study subjects undergo screening visit including standardized questionnaires day bladder diary urinalysis medical history taking vital signs physical examination neuro urological examination followed two measurement visits separated interval weeks electrical stimulations bipolar square wave pulse width applied using custom made transurethral catheter different locations lower urinary tract including bladder dome trigone proximal urethra membranous urethra distal urethra every subject randomly stimulated one specific site lower urinary tract sensory evoked potentials sep recorded using channel eeg cap sep segmental work place additional electrodes scalp cpz spine visit two three conducted identically reliability assessment discussion measurement lower urinary tract seps elicited electrical stimulation different locations lower urinary tract potential serve neurophysiological biomarker lower urinary tract afferent nerve function patients lower urinary tract symptoms disorders implementation diagnostic tool clinical practice optimized setup efficient reliable measurements data acquisition crucial addition normative data larger cohort healthy subjects would provide information variability potential confounding factors cut values investigations patients lower urinary tract dysfunction symptoms
beside major objective providing congestion control achieving predictable queuing delay maximizing link utilization robustness main objectives active queue management aqm controller paper proposes improved queue dynamic model incorporating packet drop probability well applying improved model new compensated pid aqm controller developed transmission control protocol internet protocol tcp networks non minimum phase characteristic caused pade approximation network delay restricts direct application control methods unstable internal dynamics paper parameter varying dynamic compensator operates tracking error internal dynamics proposed capture unstable internal dynamics also reduce effect uncertainties unresponsive flows proposed dynamic compensator used design pid aqm controller whose gains obtained directly state space representation system gain tuning requirements packet level simulations using network simulator show outperformance developed controller queuing delay stability resource utilization improved underlying model leads also faster response controller copyright john wiley sons ltd
previously demonstrated single treatment non peptidic delta opioid receptor agonist knt antidepressant like effect rodents forced swim test evaluated effect repeated administration potential antidepressant knt olfactory bulbectomized obx rat model male wistar rats weeks old underwent olfactory bulbectomy days surgery weighed administered either knt day selective serotonin reuptake inhibitor ssri fluoxetine day vehicle daily days hyperemotionality measured days repeated administration knt significantly decreased total individual hyperemotionality scores attack startle struggle fight entire period conversely fluoxetine show significant effect days significantly reduced total score day inhibitory effects knt greater fluoxetine knt control groups gained weight fluoxetine group lost weight results suggest knt potential lead compound antidepressant therapy high efficacy relatively rapid onset therapeutic effect without possible adverse effects weight loss caused ssris published elsevier
spectral distribution light influences microalgae productivity however development photobioreactors proceeded largely without regard spectral optimization use monochromatic light quantify joint influence path length culture density light intensity wavelength productivity efficiency synechococcus elongatus productivity green light approximate red highest levels culture density depth light intensity performance attributed combination increased dilution penetration weakly absorbed wavelength larger volume fraction reactor contrast red light outperformed wavelengths low density cultures low light intensities low density cultures also adapted rapidly reduce absorption longer wavelengths allowing prolonged cultivation taken together results indicate particularly artificially lit photobioreactors wavelength needs included critical operational parameter maintain optimal performance biotechnol bioeng wiley periodicals inc
clustering one basic tasks data mining machine learning aims discovering hidden structure data many real world applications often exist many different yet meaningful clusterings existing clustering methods produce single clustering address limitation multiple clustering tries generate clusterings high quality different emerged recently paper propose novel alternative clustering method generates non redundant multiple clusterings sequentially algorithm built upon nonnegative matrix factorization take advantage nonnegative property enforce non redundancy specifically design quadratic term measure redundancy reference clustering new clustering incorporate objective optimization problem takes simple form solved efficiently multiplicative updating rules experimental results demonstrate proposed algorithm comparable outperforms existing multiple clustering methods
paper stability local bifurcation behaviors nonlinear aeroelastic model airfoil external store investigated using analytical numerical methods three kinds degenerated equilibrium points bifurcation response equations considered characterized one pair purely imaginary eigenvalues two pairs conjugate complex roots negative real parts two pairs purely imaginary eigenvalues nonresonant case one pair conjugate complex roots negative real parts three pairs purely imaginary eigenvalues nonresonant case aid maple software normal form theory stability regions initial equilibrium point explicit expressions critical bifurcation curves obtained lead static bifurcation hopf bifurcation certain conditions tori motion may occur complex dynamical motions considered paper finally numerical solutions achieved fourth order runge kutta method agree analytic results
weighted controller structure converters proposed deal large signal operations wide range variations input voltage load conditions converters firstly divide pre defined global operation space local subspaces local linear compensator designed corresponding subspace local linear compensators weighted single controller structure weighted controller automatically decide local linear compensator regulates dynamics converter according operation conditions thus capability self adaptation wide range operating point variations furthermore prominent feature underlying weighted control scheme also nonlinearities converters easily handled linear compensation approaches easily implemented analog digital control circuitries demonstrate effectiveness controller structure stand alone converter cascaded converter system taken examples simulation experimental results
vernonia cinerea less proposed medicinal plant interesting activities aid smoking cessation worldwide despite previous clinical success smoking cessation exhibiting reduced oxidative stress approved aim study investigate various antioxidant activity active compounds approved including protective activity human red blood cells rbcs stem flower leaf extracts less vitro extracts tested antioxidant activity scavenging diphenyl picrylhydrazyl dpph radicals analyzed high performance liquid chromatography hplc active compounds total tannin five catechin compounds epicatechin gallate ecg epicatechin epigallocatechin gallate egcg epigallocatechin egc flavonoid nitrite nitrate caffeine nicotine moreover antioxidant activities extracts evaluated azobis amidinopropane dihydrochloride aaph treated rbcs results showed flower leaf less higher activity stem scavenging dpph radicals tannin content flower leaf higher stem leaf highest content five catechins egcg ecg egc flavonoid compared stem flower furthermore leaf extract higher nitrate nitrite stem nicotine content found higher leaf compared flower addition leaf showed protective activity glutathione gsh malondialdehyde mda protein carbonyl dose response aaph oxidized rbcs standard egcg thus study concluded radical scavenging antioxidant compounds catechins flavonoid nitrate nitrite nicotine present different less parts included aaph oxidized rbc model
geosynthetic tubes inflated water clay slurry sand widely used large dike construction land reclamation projects paper analytical solutions geosynthetic tube resting rigid foundation presented adopting approach similar presented leshchinsky proposed method allows quick preliminary design made using closed form solution simplify analysis relationships geometrical parameters pumping pressure established using numerical method analytical solutions compared several existing solutions good agreements achieved
treatment schizophrenic disorders still major challenge concerns acute treatment long term treatment early detection new approaches diagnostics therapy help influence course positively
paper novel technique based graph theory introduced solve sparse linear systems proposed technique enhances ability build sparse parallel solvers circuit simulation matrices thus proposed technique improves performance circuit simulation algorithms new technique represents sparse linear system signal flow graph divides graph separate strongly connected components scc sccs relations represented used enhance parallelism solver
significant energy loss results poor thermal insulations commercial public buildings windows diffuse large fraction building heating cooling energy external environment representing annual impact quadrillion british thermal unit primary energy current technology efficient windows relies upon double pane insulated glass unit insulating gas key challenge reduce thermal conductivity windows without relying insulating materials photothermal effect possibly utilized particular functionalities collect solar energy reducing heat loss insulation efficiency quantified factor defined ratio heat flux per unit area pane difference delta window interior surface exterior temperatures upon solar irradiation single panes self heat via photothermal effect nanoparticle coatings effectively reduce delta enhanced thermal insulation study photothermal effect feo nanoparticles stimulated solar light investigated nanoparticles solutions thin films energy efficient windows feo nanoparticles surface functionalized different polymers modulate colloidal stability investigation photothermal effect photothermal heating efficiencies feo different surface coatings found much greater white light irradiation near infrared nir aqueous suspension thin films mechanism photothermal effect feo identified terms band structure urbach energy band gap obtained based absorption spectra various feo nanoparticles urbach tail found consistent nanoparticle surface defect structures band gap similar corresponded electronic transitions octahedral site feo also discuss absorption based photonic physics responsible much enhanced photothermal heating white light compared nir based photothermal heating factors obtained nanoparticle coatings show promise producing energy efficient windows
knowledge discovery process discovering useful knowledge broad range sources relational databases images texts dialogues generated interaction people using natural language used source information discovered knowledge needs represented several approaches paper propose method discover knowledge task oriented dialogues representing dialogues folksonomies using novel quadripartite model folksonomies knowledge structures composed users tags resources dialogues folksonomies social dimension common renders folksonomies suited representing knowledge discovered dialogues knowledge represented folksonomies used interpret new utterances dialogue detect trends discovering topics addressed people different time intervals dialogues used learn folksonomies main difference approach past techniques use characteristics content resource discovery process experiments involving real world task oriented dialogue corpus showed using method learned folksonomies interpret utterances accuracy moreover another experiment showed possible use method determine topics addressed interlocutors dialogues elsevier ltd rights reserved
paper proposes approach robust tracking method objects intersection appearances similar target object target image sequences taken moving camera paper tracking methods using color information tend track mistakenly background region object color similar target object since proposed method based particle filter method constructs probabilistic background model histogram optical flow defines likelihood function likelihood region target object may become large leads increasing accuracy tracking probabilistic background model made density forests infer probabilistic density fast proposed method process faster authors previous approach introducing density forests results demonstrated experiments using real videos outdoor scenes
study estimates dynamic latent factor model yield curve canada using newly constructed data series term structure constant maturity zero coupon interest rates state space representation model used assess dynamic interaction three latent yield curve factors level slope curvature key macroeconomic variables real activity inflation monetary policy instrument estimates support strong macroeconomic effects future yield curve yield curve effects future macroeconomic developments bidirectional causality much stronger found research united states elsevier inc rights reserved
paper included theme challenges marine renewable energy discusses innovative concept electrical machine particularly fitted marine current turbine generators investigations focus permanent magnet direct driven synchronous generators connected variable speed power electronic drive original conventional solutions compared terms mass cost common set specifications realistic application
projection neurons play key role carrying long distance information spatially distant areas nervous system controlling motor circuits little known projection neurons distinct anatomical targets organized studies addressed spatial organization level individual cells paired commissural ganglia cogs stomatogastric nervous system crab cancer borealis projection neurons convey sensory motor modulatory information several distinct anatomical regions functions descending projection neurons dpns control downstream motor circuits stomatogastric ganglion well characterized anatomical distribution well neurons projecting labrum brain thoracic ganglion received less attention using cell membrane staining investigated spatial distribution cog projection neurons relation cog neurons retrograde tracing revealed somata associated different axonal projection pathways completely spatially segregated distinct preferences within ganglion identified dpns diameters larger cog somata restricted medial anterior ganglion contained within cluster motor neurons projecting nerve innervate labrum indicating soma position independent function target area rather findings suggest cog neurons projecting variety locations follow generalized rule nerve pathway origins soma cluster centroids closest proximity whose axons project pathway
world population million people suffering hearing loss taken account would third largest nation world current production hearing aids meets less global need one forty people hearing aids developing countries moving traffic without anybody help calling others distance reachable hand major problem faced hearing speech impaired people aim paper enable hearing speech impaired people recognize horn sound vehicles make interaction easy people similar disabilities address problem need device assist hearing challenged people responding important sounds paper proposes sound alert system detect horn sound gives alert also help calling one another indoor environment sound alert system works help microphone analog circuit microcontroller unit traffic mode hand help wireless communication module interaction mode
schisandra chinensis main constituent schizandrin sch exhibit antiinflammatory anti allergic activities allergic inflammatory reactions aggravated via caspase signaling pathway however regulatory effects sch caspase activation clarified yet study aimed clarify anti allergic effects sch using ovalbumin ova sensitized mice anti anticd antibodies stimulated splenocytes sch significantly inhibited levels immunoglobulin igg interleukin serum ova sensitized mice sch significantly inhibited levels tumor necrosis factor tnf alpha beta spleen ova sensitized mice sch significantly suppressed expression caspase receptor interacting protein rip spleen ova sensitized mice activated splenocytes sch significantly decreased expression caspase rip well production tnf alpha suggest sch exert anti allergic effect regulating caspase signaling
propose scheme broadcast satellite communication satellite radio frequency converted signals transmitted optical fiber also propose simultaneous frequency modulation converted catv converted optical transmission system one applications confirm proposals demonstrate simultaneous transport converted catv signals converted signals single optical fiber experiments carriers vsb catv channels carriers qam digital channels carriers tcpsk channels carriers qpsk channels simultaneously transmitted optical access network application practical transmission length zero dispersion optical fiber achieved using dispersion compensation fiber dcf
objectives age related changes sleep behavior well described children yet effect gender socioeconomic status ses ethnicity less clear factors important developing culturally socially appropriate guidelines healthy sleep objective study examine effects age gender ses ethnicity sleep patterns school aged children methods cross sectional survey conducted primary schools adelaide south australia parents reported demographic information sleep patterns school non school days children aged years results cohort boys mean age caucasian equal distribution across defined ses bands sleep duration reduced age shorter non school school nights result later bedtimes boys children low ses areas non caucasian children reported shorter sleep times girls children high ses areas caucasian children respectively non caucasian children low ses areas reported shortest sleep opportunity conclusions results study suggest addition biological mechanisms sleep behaviors culturally socially driven considered developing recommendations healthy sleep children elsevier rights reserved
background reduced bone formation associated increased bone marrow fat many bone loss related diseases including aging post menopause anorexia nervosa several lines evidence suggested regulation osteogenesis adipogenesis bone marrow derived mesenchymal skeletal stem cells bmscs paracrine mediators study aimed investigate impact adipocytes secreted factors cell proliferation osteoblast differentiation bmscs methods serum free conditioned medium adipo collected stromal cells derived adipocytes cell viability quantitative alkaline phosphatase alp activity assay alizarin red staining matrix mineralization osteogenic gene array expression performed determine effect adipo cell proliferation osteoblast differentiation primary murine bmscs mbmscs regulation bmps kappa signaling pathways adipo detected western blot analysis gene reporter assay results adipo showed effect cell viability proliferation primary mbmscs compared control hand adipo significantly inhibited commitment mbmscs osteoblastic cell lineage dose dependent manner adipo found dramatically inhibit bmp induced osteoblast differentiation activate inflammatory kappa signaling mbmscs interestingly treatment mbmscs selective inhibitor kappa pathway bay showed retrieve inhibitory effect adipo bmp induced osteoblast differentiation mbmscs conclusions data demonstrated marrow adipocytes exert paracrine inhibitory effect osteoblast differentiation mbmscs blocking bmps signaling mechanism mediated adipokines induced kappa pathway activation
identifying patient level disease specific predictors healthcare utilization inflammatory bowel disease ibd may allow targeted interventions reduce costs improve outcomes identify demographic clinical predictors healthcare utilization among veterans ibd conducted single center cross sectional study veterans ibd demographics disease characteristics abstracted manual chart review annual number ibd related visits estimated dividing total number ibd related inpatient outpatient encounters duration ibd care associations predictors utilization determined using stepwise multivariable linear regression overall patients ulcerative colitis crohn disease ibd unclassified ibdu mean ibd related encounters annually patients encounters compared multivariable model hispanics less visits compared caucasians african americans current smokers visits never smokers first ibd visit age pancolitis associated visits proctitis penetrating phenotype associated encounters inflammatory type found current tobacco use age first ibd visit pancolitis fistuilizing phenotype addition caucasian african american race independent predictors increased healthcare utilization interventions targeted groups decrease healthcare utilization costs
purpose review although chronic migraine common disorder severely impacts patient functioning quality life usually underdiagnosed treatment responses often remain poor even diagnosis addition effective treatment options limited due rarity randomized controlled trials rcts involving patients present review discuss updated pharmacological non pharmacological neurostimulation treatment options recent findings pharmacological treatments include acute preventive measures acute treatment options similar episodic migraine preventive treatment topiramate botulinum toxin exhibited efficacy two rcts addition several studies revealed behavioral interventions cognitive behavioral therapy biofeedback relaxation techniques associated significant improvements symptoms thus treatment options recommended patients especially refractory cases neurostimulation procedures occipital stimulation supraorbital transcutaneous stimulation non invasive vagal nerve stimulation transcranial direct current stimulation shown promising results treatment however current studies neurostimulation suffer small sample size replication negative results summary although less responsive treatment compared recent advance pharmacological non pharmacological neurostimulation treatments may provide chance successful treatment
paper examine whether source monitoring errors might one mechanism accounts traumatic memory distortion participants watched traumatic film critical crux non critical non crux scenes removed twenty four hours later completed memory test increase likelihood participants would notice film gaps inserted visual static length missing scene added manipulations designed affect people behaviour encourage systematic watching film warned half participants removed scenes encourage heuristic participants also saw labels describing missing scenes adding static highlighting missing scenes affect false recognition missing scenes however warning decreased labels increased participants false recognition rates conclude manipulations designed affect behaviour also affect degree memory distortion paradigm
quantified differences trabecular volumetric bone mineral density bmd femoral head patients proximal femoral fractures healthy subjects control group using quantitative computed tomography qct purpose providing guidance choice head screw intramedullary nail fixation participants suffering intertrochanteric fractures patients recruited addition fracture free age matched cases considered control group volumetric bmd different regions interest roi proximal femur scanned qct analyzed fracture control groups bmd proximal femur fracture group markedly lower control group significant differences distinct regions male female two groups furthermore trend bmd changes among femoral head femoral neck intertrochanter parallels terms average value conclusion osteoporosis demonstrated main risk factor proximal femoral fracture bmd value proximal femur often inconsistent femoral head given preoperative qct assessment plays important role choosing proper head screw intramedullary nail fixation
phase equilibria nonadecane decalin nonadecane naphthalene systems studied curves liquidus eutectic temperatures systems calculated using schroder chatelier equation strictly regular solutions model rsm calculated values experimental data compared
biological rhythms essential regulator life evidence circadian rhythm activity disrupted chronic stress animals humans may also less marked diseases investigated whether detectable circadian rhythm activity exists dairy cows commercial settings using real time positioning system used cowview gea farm technologies regularly record individual positions cows danish dairy farm nio infer cows activity resting feeding alley ran factorial correspondence analysis cows activities used first component analysis express variations activity axis activities obtained following weights resting alleys feeding applying weights proportions time cow spent activities able chart circadian rhythm activity found average level activity cow given clay variations day varied specific states estrus lameness mastitis specifically circadian variations activity appeared particularly sensitive vary farmer detected disorder findings offer promising avenues research design models predict physiological pathological states cows real time positioning data
violent media often blamed severe violent acts following recent findings violence movies increased substantially last decades research examined whether increases related trends severe acts violence annual rates movie violence gun violence movies compared homicide aggravated assault rates years time series analyses found violent films negatively although nonsignificantly related homicides aggravated assaults nonsignificant negative relations remained present even controlling various extraneous variables results suggest caution warranted generalizing violent media research conducted primarily laboratories via questionnaires societal trends violent behavior
understanding implementation sustainable design evolved significantly past decade today leading edge green building design teams analyze model building construction operational performance determine environmental impacts life project support analysis design community pushing manufacturers develop publish environmental product declarations epd concise credible consistent report card product impacts environment paper looks market influences epd reporting identifies latest building codes standards rating systems incentivize epds submissions review requirements developing epd based criteria product category rules content verification formatting describes manufacturer end user product benefit epd development along directory pcrs epds within cement concrete concrete products industry
day experiment carried delineate role dietary pyridoxine labeo rohita fingerlings modulating immunity prevention fungal infection two hundred seventy fingerlings randomly distributed three treatments triplicates three iso caloric isonitrogenous purified diets prepared graded levels pyridoxine three experimental groups role dietary pyridoxine modulating immunity prevention fungal infection assessed haemato immunological parameters like erythrocyte counts leucocyte counts haemoglobulin packed cell volume pcv mean corpuscular volume mcv mean corpuscular haemoglobin mch mean corpuscular haemoglobin concentration mchc nitro blue tetrazolium nbt phagocytic activity albumin globulin total plasma protein albumin globulin challenge study saprolegnia parasitica relative percentage survival rps recorded pcv mcv mch nbt total plasma protein albumin globulin contents lysozyme phagocytic activity significantly higher fed group significantly higher rps recorded group fed days hence capacity stimulate nonspecific immunity increase resistance parasitica infection rohita fingerlings elsevier ltd rights reserved
coupled green building roof system assess bidirectional heat flux indoor space two high rise residential blocks humid subtropical hong kong without roof building thermal insulation bti monitored thermal performance across seasons weather conditions block three plots sedum herbaceous peanut green roofs plus bare control diurnal heat flux data partitioned daytime nighttime positive negative fractions hot summer sunny day control without bti facilitates notable daytime influx nighttime efflux heat sedum augments thermal mass effect pushing heat indoor control balance transpirationcooling heat sink formation peanut registers intermediate heat gain adding bti raises heat gain eliminates control heat loss curtails sedum heat gain maintains peanut heat gain bti partnering green roof offer synergistic thermal benefit increasing thermal mass thermal capacity thermal resistance furnish thermal buffering thermal lag extending heat ingress nighttime lower solar radiation input summer cloudy day significantly trims heat gain control limited reduction green roofs summer rainy day brings drop heat gain cloudy rainy scenarios heat gain suppression notable bti interpretations season weather conditions implications findings elaborated elsevier ltd rights reserved
paper present technological solution implementing force feedback haptic interface context virtual reality interaction applications real time haptic algorithms implemented twincat runtime environment control drivers via ethercat fieldbus dimensional visualization model virtual reality interaction developed virtual reality toolbox matlab simulink interconnected twincat software automation device specification communication protocol using matlab simulink model based programming method instead programming language allows researchers haptic domain focus control engineering issues programming skills experimental tests verification haptic algorithms visualization model presented
dendritic hpg amid mpeg core multishell nanocarriers cms represent novel class unimolecular micelles hold great potential drug transporters facilitate topical therapy skin diseases atopic dermatitis among common inflammatory skin disorders complex barrier alterations may affect efficacy topical treatment tested penetration behavior identified target structures unloaded cms topical administration healthy mice mice oxazolone induced atopic dermatitis examined whole body distribution possible systemic side effects simulating high dosage dermal penetration subcutaneous injection following topical administration cms accumulated stratum corneum without penetration deeper viable epidermal layers observed atopic dermatitis mice indicating barrier alterations atopic dermatitis influence penetration cms following subcutaneous injection cms deposited regional lymph nodes well liver spleen lung kidney however vitro toxicity tests clinical data morphometry assisted histopathological analyses yielded evidence toxic otherwise adverse local systemic effects cms affect severity course atopic dermatitis taken together cms accumulate stratum corneum healthy inflammatory skin appear highly biocompatible mouse even conditions atopic dermatitis thus could potentially serve create depot anti inflammatory drugs skin
physiologic adaptations pregnancy unmask woman predisposition diseases complications increasingly predicted first trimester algorithms amplify pre existing maternal phenotype accelerate risks chronic diseases offspring adulthood barker hypothesis recent evidence suggests vice versa pregnancy diseases also indicate maternal even grandparent risks chronic diseases reverse barker hypothesis pub med embase reviewed mesh terms fetal programming pregnancy complications combined maternal disease january studies linking pregnancy complications future cardiovascular metabolic thrombotic risks mother offspring reviewed women history miscarriage fetal growth restriction preeclampsia preterm delivery obesity excessive gestational weight gain gestational diabetes subfertility thrombophilia frequently demonstrate echocardiographic abnormalities higher fasting insulin deviating lipids clotting factors show defective endothelial function thrombophilia hints thrombotic risks later life pregnancy abnormalities correlate future cardiovascular metabolic complications earlier mortality conversely women normal pregnancy lower rates subsequent diseases general female population creating term pregnancy window future health although placenta works gatekeeper many pregnancy complications may lead sickness earlier death later life child becomes adult epigenetic mechanisms mismatch pre postnatal life created term fetal origin adult disease impact cardiovascular metabolic thrombotic risk profiles investigated separately mother child manuscript strive illustrate consequences fetus mother within cohesive perspective thus try demonstrate complex interrelationship genetics epigenetics long term health societies future generations maternal fetal medicine specialists key role prevention non communicable diseases implementing framework patient consultation interdisciplinary networks health care providers policy makers increasingly invest stratified primary prevention follow reduce increasing number manifest cardiovascular metabolic diseases prevent waste health care resources
quantum phase transition thermodynamics periodic anderson like polymer chain magnetic field investigated green function theory phase diagram explored wherein crossover temperature denoting gapless phase crossover quantum critical regimes smoothly connects near critical fields universal linear line similar ends providing new route capture quantum critical point qcp quantum critical scaling around qcps demonstrated analyzing magnetization specific heat gruneisen parameter gamma provide direct access distill power law critical exponents beta delta alpha obeying critical scaling relation alpha beta delta analogous quantum spin system furthermore scaling hypothesis equations proposed check scaling analysis data collapse onto single curve two independent branches plot appropriate scaling variable indicating self consistency reliability obtained critical exponents elsevier rights reserved
neuropeptide oxytocin oxt facilitates prosocial behavior selective sociality context stress oxt also regulate hypothalamic pituitary adrenal hpa axis activity leading consideration oxt potential treatment many socioaffective disorders however mechanisms administration exogenous oxt modulates social behavior stressful environmental contexts fully understood investigate hypothesis autonomic pathways components mechanisms oxt aids recruitment social resources stressful contexts may elicit mobilized behavioral responses female prairie voles microtus ochrogaster underwent stressor walking shallow water following pretreatment intraperitoneal oxt oxt antagonist oxt allowed recover without sibling cagemate administration oxt resulted elevated oxt concentrations plasma dampen hpa axis response stressor however oxt oxt pretreatment prevented functional coupling usually seen absence oxt paraventricular nucleus pvn activity measured fos immunoreactivity hpa output corticosterone release furthermore oxt pretreatment resulted functional coupling pvn activity brain regions regulating sympathetic rostral ventrolateral medulla parasympathetic dorsal vagal complex nucleus ambiguous branches autonomic nervous system findings suggest oxt increases central neural control autonomic activity rather strictly dampening hpa axis activity provides potential mechanism oxt may facilitate adaptive context dependent behavioral physiological responses stressors published elsevier inc
stem cell factor scf critical protein key roles cell hematopoiesis gametogenesis melanogenesis present study comparative analysis nucleotide sequences scf performed humanoids using bioinformatics tools including ncbi blast mega jbrowse analysis nucleotide sequences find closely evolved organisms high similarity ncbi blast tools mega showed human chimpanzee pan troglodytes placed cluster using jbrowse found scf neanderthal single copy number similar modern human partly conserved nucleotide sequences together results approved gene flow genetics similarity scf among human troglodytes may suggest evolution scf gene transferred partly intact either basis sequence function ancestors troglodytes ancient human like neanderthal modern human
systemic sclerosis ssc rare multisystem connective tissue disorder characterized triad fibrosis vasculopathy immune dysregulation chronic disease significant impact orofacial region involved two thirds cases ssc patients show wide array oral manifestations usually associated severe impairment quality life often present decreased salivary flow reduced mouth opening contribute substantially worsening oral health status therefore ssc patients require specific multidisciplinary interventions initiated early possible identification specific radiological clinical signs early stage improve management patients study reviews wide spectrum orofacial manifestations associated ssc suggests clues oral management remains challenging
introduction atrial fibrillation frequently encountered complication coronary artery bypass grafting cabg underlying mechanisms still unclear natriuretic peptides reported markers predicting occurrence postoperative study evaluates whether scal anp gene polymorphisms predict occurrence postoperative material methods prospective study consecutive patients coronary artery disease undergoing elective cabg undertaken atrial natriuretic peptide anp scal gene polymorphism several perioperative data analysed postoperative defined lasting least min confirmed lead ecg occurring within postoperative days scal polymorphism anp gene determined polymerase chain reaction pcr size dependent separation pcr products polyacrylamide gel followed staining ethidium bromide results total frequency frequencies scal anp gene polymorphisms follows order assess hypothesis allele marker increased risk postoperative atrial fibrillation odds ratio calculated non significant odds ratios significant either non non conclusions anp genotype predispose incidence new set
background previous studies postulated association migraine excessive daytime sleepiness eds study evaluated association eds migraine headache frequency general population adjusting potential confounding variables methods study postal survey random age gender stratified sample persons aged years old drawn national population register norway questionnaire included questions migraine headache epworth sleepiness scale ess various comorbidities eds defined ess association eds migraine headache analysed bivariate multivariable logistic regression analyses results total persons responded ess included analyses odds ratio eds increased migraineurs compared non migraineurs however finding significant adjustment number possible confounders eds increased increasing headache frequency days per year compared without headache multivariable analysis conclusions general population odds eds increased significantly headache frequency irrespective migraine status eds associated reported migraine multivariable analysis
one main concern related performance unsaturated soils construction service life earthen structures loss matric suction due seasonal variations gravimetric water content gwc ground water infiltration possible development excess pore water pressure addition reducing soil shear strength loss matric suction result wetting could also reduce soil reinforcement interface shear strength comparison built value lower gwc paper presents results small scale pullout interface tests woven geotextile reinforcement material different marginal soils order quantify difference soil geotextile interface shear strength function gwc practical applications moisture reduction factor mrf omega used account reduction soil geotextile interface shear strength function matric suction range gwc values includes dry wet sides soil optimum gravimetric water content gwc opt optimum moisture content omc observed interface shear strength geotextile reinforcement marginal soils could significantly lower much wet optimum omc comparison omc assumed represent built condition
autism characterised difficulties social functioning notably interactions people yet studies addressing social difficulties used static images best videos social stimuli scope real interaction study one crucial aspect social interactionsgaze behaviourin interactive setting first typical individuals shown videos experimenter means deception procedure either led believe experimenter present via live video feed pre recorded participants eye movements revealed passively viewing experimenter believed live looked less person believed experimenter video pre recorded interestingly reduction viewing behaviour response believed live presence experimenter absent individuals high autistic traits suggesting relative insensitivity social presence alone participants asked actively engage real time interaction experimenter however high autistic trait individuals looked significantly less experimenter relative low autistic trait individuals results reinforce findings atypical gaze behaviour individuals high autistic traits suggest active engagement social interaction may important eliciting reduced looking propose difficulties spatio temporal dynamics associated real social interactions rather underlying difficulties processing social stimulus may drive effects results underline importance developing ecologically valid methods investigate social cognition autism res authors autism research published wiley periodicals inc behalf international society autism research
causes psychopathy condition characterized interpersonal superficial charm affective lack empathy behavioral impulsive actions features remain contested present review examines influential etiological models psychopathy response modulation hypothesis rmh proposes psychopathic individuals exhibit difficulties adjusting behavior presence dominant response set conduct meta analysis narrative literature review examine rmh quantitatively qualitatively estimate statistical effects response modulation deficits psychopathic individuals ascertain boundary conditions rmh ninety four samples published unpublished studies involving participants identified inclusion overall results provided support rmh revealing small medium relationship psychopathy deficits extended psychopathy dimensions moreover predicted rmh deficits observed affectively neutral affectively laden tasks number moderators anxiety laboratory task dependent measure psychopathy measure race contributed significant variability effect sizes also found evidence potential publication bias using methods raising questions concerning robustness findings ancillary narrative review revealed rmh inconsistent number replicated findings psychopathy literature suggesting rmh least present form unlikely provide comprehensive etiological account psychopathy nevertheless recent attentional versions rmh may hold promise respect intervention fruitful directions research rmh including use multiple dependent measures latent variable approaches delineated
paper describes conservation figurative geometrical patterned century mosaic ruins house ionic capitals hierapolis one world heritage sites mosaic significant quantity detached disintegrated tesserae result deterioration bedding layer conservation process included fixing detached tesserae reinforcing bedding layer lime mortars integrating disintegrated original tesserae fill small lacunae better visual perception mechanical poultice cleaning using permeable geotextile reburial environmental factors herbicide application prevent plant intrusion elsevier masson sas rights reserved
reduction testosterone levels men aging associated cognitive decline risk dementia animal studies shown benefits testosterone supplementation improving cognition reducing alzheimer disease pathology randomized placebo controlled crossover study men subjective memory complaint low testosterone levels investigated whether testosterone treatment significantly improved performance various measures cognitive functioning forty four men administered battery neuropsychological tests establish baseline prior randomly divided two groups first group group received weeks testosterone treatment treatment followed weeks washout weeks placebo second group group received treatments reverse order placebo washout treatment group tep compared baseline modest point significant improvement general cognitive functioning measured mini mental state examination mmse following testosterone treatment improvement baseline sustained following washout period crossover placebo treatment similar mini mental state examination mmse scores observed comparing testosterone treatment placebo group pet significant increase observed baseline following testosterone treatment trend towards increase compared placebo treatment improvements baseline depression scores assessed geriatric depression scale observed following testosterone placebo treatment groups difference observed comparing testosterone placebo treatment findings indicate modest improvement global cognition testosterone treatment larger clinical trials longer follow inclusion blood brain imaging markers needed conclusively determine significance testosterone treatment
examined schema affects recognition memories subjective experiences actions objects first participants watched consecutive slides described man kitchen slides man performed schema consistent actions schema inconsistent actions schema consistent objects schema inconsistent objects left kitchen space watching slides participants completed recognition test remember know test perception thought emotion context questionnaire objects discrimination targets distracters accurate schema inconsistent items schema consistent items owing perceptual thought emotional recollections schema inconsistent object targets actions schema consistent targets frequently recognized schema inconsistent targets remember judgments based perceptual contextual recollections item specific information schema inconsistent targets could elaborated objects perceptual details contextual relationship schema consistent targets could elaborated actions also found less false recognitions schema consistent action distracters schema consistent object distracters retrieval perceptual details schema consistent action targets could prevent false recognitions schema consistent action distracters
smart grid integrates electrical network communication systems information technologies increasing architecture interdependency introducing new challenges evaluation possible threats could affect security reliability power system cyber attacks widely studied consequences physical failures real time applications starting receive attention due implications power system security paper presents methodology quantify impact observability state estimation possible disruptive failures common transmission infrastructure numerical results obtained calculating observability indicators ieee bus test case considering simultaneous disconnection power transmission lines communication links installed infrastructure
interleukin receptor associated pathogenesis multiple sclerosis though mechanisms clear myelin expression highly conserved zebrafish mammals zebrafish become ideal model studying demyelination used transgenic mbp nfsb egfp zebrafish line oligodendrocytes expressed green fluorescent protein gfp larval stage adulthood exposing adult transgenic zebrafish metronidazole induced demyelination resembled morphological changes associated early stages metronidazole induced demyelination confirmed magnetic resonance imaging mri first time microarray analysis revealed regulation demyelination targeted knockdown demonstrated essential myelination embryonic larval zebrafish moreover regulation induced signaling via jak stat pathway leading apoptosis oligodendrocytes findings contribute understanding role demyelination provide rationale development based therapies demyelinating diseases
background nutrition training boost competence health workers improve children feeding practices way child undernutrition ameliorated general populations however evidence lacking efficacy interventions among human immunodeficiency virus hiv positive children aimed examine efficacy nutrition training intervention improve midlevel providers mlps nutrition knowledge feeding practices nutrition statuses hiv positive children tanga tanzania methods cluster randomized controlled trial conducted care treatment centers ctcs intanga eight ctcs assigned intervention arm total mlps received nutrition training provided nutrition counseling care caregivers hiv positive children total pairs hiv positive children caregivers recruited intervention arm data analyzed using instrumental variable random effects regression panel data examine efficacy intervention nutrition status feeding practices results mean nutrition knowledge scores higher post training compared pre training among mlps mean increment weight gain also observed follow compared baseline among children intervention arm feeding frequency dietary diversity improved following intervention months follow increase unit feeding frequency dietary diversity associated unit unit respectively decrease child underweight conclusions nutrition training improved nutrition knowledge among mlps caring hiv positive children attending ctcs tanga tanzania caregivers feeding practices also improved turn led modest weight gain among hiv positive children sustain weight gain efforts made also improve households food security caregivers education addition inservice nutrition trainings protocol registered recruitment isrctn trial registry trial registration number isrctn
paper discusses findings measurement campaign rotating wind turbine blade operating free atmosphere realistic conditions total pressure sensors together array usable hot film sensors based constant temperature anemometry used study behavior boundary layer within specific zone suction side diameter wind turbine different operational states set several hundreds data sequences recorded show certain circumstances flow may regarded fully turbulent accompanying computational fluid mechanics cfd simulations suggest view classical transition scenario according growth called tollmien schlichting apply copyright john wiley sons ltd
internet things iot inspired solutions already available addressing problems various application scenarios healthcare security emergency support tourism however clear approach modeling systems envisioning capabilities design time therefore process designing systems hoc real impact evaluated solution already implemented risky expensive paper proposes modeling approach uses human centric wireless sensor networks specify evaluate models iot based systems time design avoiding need spend time effort early implementations immature designs allows designers focus system design leaving implementation decisions next phase article illustrates usefulness proposal running example showing design iot based solution support first responses medium sized large urban incidents case study used proposal evaluation based real train crash proposed modeling approach used design iot based systems application scenarios support security operatives monitor chronic patients homes
paper presents design control pneumatically actuated transtibial prosthesis utilizes pneumatic cylinder type actuator power prosthetic anlde joint support user locomotion pneumatic actuator multiple advantages traditional electric motor light weight low cost high power weight ratio objective work develop compact lightweight transtibial prosthesis leveraging multiple advantages provided highly competitive actuator paper design details prosthesis described including determination performance specifications layout actuation mechanism calculation torque capacity authors design calculation prosthesis able provide sufficient range motion torque capacity support locomotion individual controller design also described including underlying biomechanical analysis formulation finite state impedance controller testing results human subject indicate prosthesis able generate natural walking gait sufficient power output amputee user
background objective study identify importance number potential factors affecting likelihood sexual activity perimenopausal women likelihood number barriers sexual activity methods cohort women undergoing menopausal transition surveyed annually years data collected sexual activity sexually active reasons sexual activity well number potential risk factors height weight measured annual clinic visit serum hormone concentrations assayed using blood samples donated annually data examined logistic regression models using individual random effect subset analysis nonsexually active women determine likelihood barrier factors univariate associations considered multivariate model building stepwise addition results total woman years included analysis sexual activity likelihood sexual activity increased women living partner perceived quality life less frequent hot flashes among woman years reporting sexual activity women living partner women reporting frequent fatigue less likely lack sexual partner likely sexual difficulties women physical work average women higher serum estradiol levels less likely sexual difficulties conclusions factors associated sexual activity menopausal women complex indicating individualized approach improving sexual activity required
fibrotic disorders associated tissue accumulation fibroblasts recently showed caveolin cav gene suppression profibrotic cytokine transforming growth factor tgf beta contributes fibroblast proliferation apoptosis resistance cav shown constitutively suppressed idiopathic pulmonary fibrosis ipf mechanisms suppression incompletely understood hypothesized epigenetic processes contribute cav regulation ipf lung fibroblasts fibrogenic stimuli cav expression levels dna methylation status histone modifications associated cav promoter examined pcr western blots pyrosequencing chromatin immunoprecipitation assays ipf lung fibroblasts normal fibroblasts tgf beta stimulation murine lung fibroblasts bleomycin injury methylation specific pcr demonstrated methylated unmethylated cav dna copies groups despite significant changes cav expression changes dna methylation observed cpg islands cpg island shores cav promoter pyrosequencing lung fibroblasts ipf lungs response tgf bleomycin induced murine lung injury compared respective controls contrast association cav promoter active histone modification mark lysine trimethylation correlated cav regulation activated fibrotic lung fibroblasts data indicate cav gene silencing lung fibroblasts actively regulated epigenetic mechanisms involve histone modifications particular lysine trimethylation whereas dna methylation appear primary mechanism findings support therapeutic strategies target histone modifications restore cav expression fibroblasts participating pathogenic tissue remodeling
internet based cyber physical world profoundly changed information environment development artificial intelligence bringing new wave research promoting new era one prominent characteristics research era crowd intelligence attracted much attention industry research communities specifically crowd intelligence provides novel problem solving paradigm gathering intelligence crowds address challenges particular due rapid development sharing economy crowd intelligence becomes new approach solving scientific challenges also integrated kinds application scenarios daily life online offline application real time traffic monitoring logistics management paper survey existing studies crowd intelligence first describe concept crowd intelligence explain relationship existing related concepts crowdsourcing human computation introduce four categories representative crowd intelligence platforms summarize three core research problems state art techniques crowd intelligence finally discuss promising future research directions crowd intelligence
study tried employ state art multi objective uniform diversity genetic algorithm muga pareto optimization pid controllers load frequency control lfc power systems first multi objective optimization linear non reheat two area interconnected power system conducted respect three conflicting objective functions gains pid controllers considered design variables objective functions integral time multiply absolute error itae minimum damping ratio dominant eigenvalues settling times frequency tie line power deviations illustrate superiority muga finding optimum values deign variables proposed designs muga compared proposed single multi objective optimization methods bfoa hbfoa pso nsga results indicate noticeable improvement response system robustness proposed designs demonstrated varying system parameters nominal values monitoring sensitivity system response variations end take nonlinearities physical constraints account evaluate performance muga complex system three unequal area hydro thermal system generation rate constraints considered elsevier ltd rights reserved
background given growing numbers older adults mental substance use disorders msuds study examined association ten types adverse childhood experiences aces lifetime msuds among aged methods data age group came national epidemiologic survey alcohol related conditions using multivariable binary logistic regression analyses examined relationships ten aces six lifetime msuds major depressive disorder mdd anxiety post traumatic stress alcohol use drug use nicotine use disorders gender differences examined using tests interaction effects gender separate logistic regression models results sample women men reported least one ace genders parental adult substance abuse prevalent followed physical abuse emotional neglect child abuse neglect parental adult mental illness substance abuse small consistently significant associations msuds odds ratio parental adult substance misuse mdd although relationship total number aces andmsuds cumulative men women associations physical abuse sexual abuse emotional neglect parental separation divorce msuds stronger among men conclusions study underscores significant yet modest association aces lifetime msuds late life research needed investigate aces seem greater effects older men discern sources gender differences aces effects
chronic pain patients increasingly seek treatment mindfulness meditation study aims synthesize evidence efficacy safety mindfulness meditation interventions treatment chronic pain adults conducted systematic review randomized controlled trials rcts meta analyses using hartung knapp sidik jonkman method random effects models quality evidence assessed using grade approach outcomes included pain depression quality life analgesic use thirty eight rcts met inclusion criteria seven reported safety found low quality evidence mindfulness meditation associated small decrease pain compared types controls rcts statistically significant effects also found depression symptoms quality life mindfulness meditation improves pain depression symptoms quality life additional well designed rigorous large scale rcts needed decisively provide estimates efficacy mindfulness meditation chronic pain
aims assess efficacy safety abobotulinumtoxina dysport adult patients neurogenic detrusor overactivity ndo methods phase iia international multicentre double blind randomised placebo controlled pilot study enrolled patients ndo urinary incontinence resulting spinal cord injury sci multiple sclerosis patients treated intra detrusor injections dysport equivalent placebo injections dysport equivalent placebo primary endpoint change baseline mean number daily incontinence episode frequency ief day secondary endpoints included change baseline urodynamic parameters quality life qol safety assessment also conducted results adjusted mean changes baseline ief injections dysport placebo groups respectively injections dysport placebo groups respectively statistically significant improvements maximum cystometric capacity maximum detrusor pressure volume first contraction reported dysport groups compared placebo improvements qol reported three muscle weakness episodes reported serious adverse events two tetraplegic one paraplegic patient injections dysport group conclusions injections administration modes dysport decreased daily ief resulted significant improvements urodynamic parameters ndo patients sci reduction injection sites appear associated impact efficacy wiley periodicals inc
modulatory actions glutamate main excitatory neurotransmitter central nervous system cns exerted activation metabotropic glutamate receptors mglurs eight known mglurs mglur group iii mglurs mglur mglur mglur mglur less understood lack selective ligands except mglur group iii mglurs widely distributed throughout cns mainly located presynaptic terminals inhibit neurotransmitter release glutamatergic aminobutyric acid gaba ergic synapses location certain synapses considered critical normal cns function makes potential targets neurological psychiatric treatments novel ligands selective group iii mglur subtypes recently developed compounds mainly targetallosteric sites act positive negative allosteric modulators pams nams glutamate transmission contributing understanding functional roles group iii mglurs number pathological conditions epilepsy anxiety neurodegenerative diseases chronic pain moreover presence group iii mglurs throughout entire pain neuraxis particularly descending system suggests endogenous substrates extend cortex first spinal synapse candidates pain control recent data chronic pain alleviation group iii mglur ligands encourage studies pathological pain one troublesome diseases current lack satisfactory therapy review summarizes recent studies group iii mglurs animal models chronic pain evidence opposite modulation mglur mglur pain responses capability affect pain responses pathological states
spent nuclear liquid waste often kept partially filled storage tanks storage tanks subjected wind earthquake induced excitations could lead detrimental conditions therefore storage tank designers ensure safe design margins develop methodologies overcome wide range possible scenarios present study systematic numerical simulations carried investigate sloshing dynamics liquid storage tank subjected seismic excitation precursor influence resonant harmonic excitation free surface displacement pressure distribution slosh forces etc studied suppress free surface fluctuations associated slosh force two types baffles viz ring vertical baffle examined based response imposed harmonic excitation vertical baffle plate middle tank found effective dimensions systematically optimized baffle geometry tested well known seismic excitation centro observed effectively suppress free surface fluctuations slosh forces elsevier ltd rights reserved
damage detection full scale nine story reinforced concrete building investigated using forced vibration test fvt building former civil architecture department tohoku university located sendai japan earthquake resistance elements building severely damaged miyagi ken oki earthquake building retrofitted fvt performed structure retrofitting sensor arrangement using data acquired sensors system identification performed using rational fraction polynomial damage assessment detection location done modal assurance criterion derivatives results indicate detected damages location using method corresponds actual damages occurred structure
background volumes paracardial adipose tissue pat epicardial adipose tissue eat greater menopause interestingly pat eat associated estradiol decline suggesting potential role menopause pat accumulation assessed whether volumes heart fat depot eat pat associated coronary artery calcification cac women midlife whether associations modified menopausal status estradiol levels methods results eat pat volumes cac measured using electron beam computed tomography scans cac evaluated presence cac cac agatston score extent cac log cac agatston score study included women aged years pre early perimenopausal late perimenopausal postmenopausal eat significantly associated cac measures associations modified menopausal status estradiol contrast associations pat cac measures modified menopausal status interaction independent study covariates including adiposity measures unit increase log pat associated higher risk cac presence increase cac extent postmenopausal women compared pre early perimenopausal women additional adjustment estradiol hormone therapy attenuated differences moreover association pat cac extent stronger women lower estradiol levels interaction conclusions findings suggest pat potential menopause specific coronary artery disease risk marker supporting need monitor target fat depot intervention women midlife
recent heterogeneous system designs integrate general purpose processors gpus specialized accelerator devices single platform provide power performance benefits important support efficient dispatching mechanisms terms performance programmability work proposes models integrating hardware accelerators applications executing standard operating systems embedded processor instead using direct mapping accelerator units user applications using legacy drivers incur communication overheads large programming effort develop abstraction layer kernel driver driver communicates custom dispatcher interface number hardware accelerators time remove need include iommus virtual physical translation device side need perform copies user kernel space offtoading computational instensive tasks accelerators demonstrate effectiveness solutions running real applications prototype hybrid heterogeneous system chip platform
california commission immigration housing ccih unveiled bold new experiment home teacher program los angeles program sent volunteers mexican communities teach immigrant women new american ways homemaking childrearing lesson plans sample dialogues teacher testimonies photographs featured ccih publications provide fascinating window tense interactions home teachers immigrant women scholars long explored different ways mining institutional records forms writing americanization advocates insights experiences participated programs essay contributes discussion california americanization curricula two ways first provide close reading ccih texts order uncover analyze three layers recorded experience teacher biases confronted immigrant women immigrant women difficult material realities immigrant women complex responses americanization second provide evidence view mexican immigrant women responded americanization efforts variety ways outright resistance milder forms pushback times conditional acceptance american customs presented light evidence argue mexican immigrant women impossible laying claim piece california complex relationship negotiated home teachers although americanization programs intended flatten mexican women ethnic affiliations immigrant women found subtle ways assert agency survive hardship prejudice forge new mexican american ethnic community process
contemporary china experiencing deeper reform social transformation newly born social media participated historical process china reform social change based existing literature social media internet public events article aims study china internet public events perspective social transformation theory especially theories civic society public sphere study used case study explore role social media play social change china depth analysis typical cases found social media important information source means online civil mobilization also provide citizens open free space discussion internet public events impact social media promoting social change reflected supervision governmental judiciary public power maintenance justice protection disadvantaged groups attracting government attention urging governmental information publicity investigation events promoting social management innovation institutional change social media helpful force construction internet public sphere civil society contemporary china meanwhile necessary cautious social media also likely breeding ground nationalist populist discourses elsevier ltd rights reserved
objectiveprognosis following first demyelinating event difficult predict genetic markers progression currently identified myelin basic protein mbp major component myelin sheath cns neurons may play central role demyelinating diseases however genetic variation mbp implicated onset risk large genome wide association studies hypothesized genetic variations mbp may determinant clinical course materials methodswe investigated whether variations mbp gene altered clinical course conversion relapse annualized change disability using prospectively collected longitudinal cohort study persons first demyelinating event followed year review resultswe found one variant predicted worse clinical outcomes risk genotype significantly associated hazard relapse greater annualized disability progression also found significant interaction risk genotype baseline anti hhv igg predicting interaction relapse interaction functional prediction analysis showed variant target many transcription factors binding sites mir mir conclusionsour results provide novel insights role genetic variation within mbp gene predicting clinical course directly interaction known environmental risk factors
model based control designs advantage controlling complex systems assuring global system stability comparison ordinary linear controllers pid controllers paper attempts promote use model based control designs industrial applications particularly marine system industry simple pendulum system used example help compare backstepping sliding mode controller pid controller display main steps deriving model based control design consistent manner highlight benefits using model based control laws comparison standard pid based control laws results example indicate model based controller barely affected changes system parameters comparison pid controller must retuned time system parameters changed indicates lookup table controller gains interpolation needed pid controller used controlling system changing system parameters highly nonlinear dynamics furthermore offshore hydraulic winch system used depth case study system thoroughly analyzed based simple fluid dynamics mechanics dynamics general simplified state space model highly nonlinear model describes main characteristics hydraulic system developed used derivation speed controller torque controller hydraulic winch system process plant model describing hydraulic winch system together lumped wire load model used simulations test verify derived control laws seem well suited controlling hydraulic system based observations results obtained work indicated pid controller would able control hydraulic winch system large stability region well model based controller huge amount work done tuning making lookup tables interpolation algorithms controller gains argues use model based control designs industrial applications containing nonlinear dynamics varying system parameters elsevier ltd rights reserved
paper focuses radicalization parenting perspective propose approach sees radicalization possibility adolescent development part interaction adolescent social environment socialization aim study discover parents react adolescent develops extreme ideals using depth interviews young people extreme ideals parents parental reactions towards ideals explored subsequently reactions categorized according two dimensions control support study shows parents struggle confronted radicalization shift less demanding responses due powerlessness dissociation parental uncertainty
synaptic dysfunction loss strongest pathological correlate cognitive decline alzheimer disease increasing evidence implicating neuropathological tau protein process despite knowledge tau spreads defined synaptic circuits currently unknown whether synapse loss occurs accumulation tau consequence address used array tomography examine rtgtauec mouse model expressing human tau transgene transgene labeling cytoplasm red tdtomato presynaptic terminals green synaptophysin egfp transgenes restricted primarily entorhinal cortex using neuropsin promotor drive tta expression previously shown rtgtauec mice exhibit neuronal loss entorhinal cortex synapse density loss middle molecular layer mml dentate gyrus months age observed density tau expressing total presynapses spread tau postsynapse mml month old red green rtgtauec mice observe loss synapse density mml months even axons expressing tau despite maintenance synapse density see spread human tau presynaptic terminals postsynaptic compartments mml early ages indicating spread tau neural circuits due degeneration axon terminals early feature disease process
adults adaptive interactions intimate partners enhance well hypothesized adult males physiological responses opposite sex conspecifics distress result interaction environmental factor early social interaction caregivers genetic factor polymorphism within promoter region serotonin transporter gene httlpr assessed heart rate changes non married male adults distress vocalizations female infant bonobo cries males early interaction parents assessed using parental bonding instrument buccal mucosa cell samples collected assess httlpr genotype significant interaction emerged early experience genetic predisposition males genetic predisposition higher sensitivity environmental factors showed atypical physiological responses adult female cries according experienced early maternal parenting environmental experiences genetic characteristics associated adult males physiological responses socially meaningfully stimuli understanding mechanisms modulate responses opposite sex conspecifics may improve personal well social adaptiveness
report deals loading geomembrane construction phase inner shell tunnel systematic parameter analysis institute underground construction munster geomembrane geotextile tested different realistic conditions laboratory testing showed dependence seal support surface shotcrete characteristics geotextile deformations membranes due fresh concrete pressure significantly smaller permitted values technical regulations main results investigations described
despite increasing utilization chromosomal microarray analysis cma autism spectrum disorders asd limited information exists results influence parents beliefs etiology prognosis conducted depth interviews surveys parents children asd received cma results categorized pathogenic negative variant uncertain significance parents tended incorporate child cma results within existing beliefs etiology asd regardless cma result however parents expectations future tended differ depending results received genetic confirmation children asd expressed sense concreteness acceptance permanence condition parents expressed hope future biomedical treatments result genetic research
significant minority women menopausal symptoms unpleasant however many worried taking menopausal hormone therapy mht fear causing breast cancer micronised progesterone available europe since clinical trials shown oral daily oral sequentially vaginal every second day effectively protect endometrium stimulatory effects oestrogen mht containing significantly lower breast cancer risk containing progestins micronised progesterone appear attenuate cardiovascular benefits oestrogen pharmaceutical grade body identical mht available australia
background vitamin deficiency emerging epidemic especially minority populations vitamin crucial bone health proper brain development functioning low levels vitamin associated depression seasonal affective disorder schizophrenia adults little known vitamin mental health pediatric population methods one hundred four adolescents presenting acute mental health treatment month period assessed vitamin status relationship vitamin levels severity illness defined presence psychotic features results vitamin deficiency levels present vitamin insufficiency levels present remaining normal range adolescents psychotic features lower vitamin levels association vitamin deficiency psychotic features substantial race independently associated vitamin deficiency independently associated psychosis asian biracial white race longer associated psychosis results adjusted vitamin level conclusions vitamin deficiency insufficiency highly prevalent adolescents severe mental illness preliminary associations vitamin deficiency presence psychotic features warrant investigation whether vitamin deficiency mediator illness severity result illness severity higher prevalence vitamin deficiency greater risk psychosis african americans confirmed may special implications health disparity treatment outcome research
aimsthe aim study compare expression urinary nerve growth factor ngf brain derived neurotrophic factor bdnf substance calcitonin gene related peptide cgrp women without overactive bladder oab sought determine factors associated higher expression neuropeptides methodsparticipants oab age matched controls enrolled symptom severity assessed validated questionnaires urinary neurotrophin levels symptom scores clinical data compared groups multivariate analysis determined independent factors associated urinary neurotrophin levels resultssixty seven women oab controls included women oab controls similar age race body mass index parity smoking status women oab likely report history pelvic pain pelvic surgery neurotrophic factor levels normalized urinary creatinine differ groups increasing age associated greater urinary levels bdnf ngf respectively higher urinary ngf associated increasing bmi pain associated elevated urinary conclusionsour data support relationship urinary neurotrophin levels oab age matched postmenopausal women research necessary elucidate role urinary neurotrophins diagnosis management oab neurourol urodynam wiley periodicals inc
contemporary rdbms based systems visualization high volume numerical data difficulty cope hard latency requirements high ingestion rates interactive visualizations existing solutions lowering volume large data sets disregard spatial properties visualizations resulting visualization errors work introduce vdda visualization driven data aggregation models visual aggregation pixel level data aggregation query level based aggregation producing pixel perfect line charts highly reduced data subsets define complete set data reduction operators simulate overplotting behavior frequently used chart types relying relational algebra common data aggregation functions approach generic applicable visualization system consumes data stored relational databases demonstrate visualization driven data aggregation using real world data sets high tech manufacturing stock markets sports analytics reducing data volumes two orders magnitude preserving pixel perfect visualizations producible raw data
present paper probability distribution function derived sum squares random variables nonzero expectations distribution function enables one develop efficient one step algorithm phase ambiguity resolution determining spatial orientation signals satellite radio navigation systems threshold values rejecting false solutions statistical properties algorithm obtained
paper present novel sensor array manufacturing process involves transfer printing methods using chip mounter vacuum collet using methods one mount ultra thin microsensors also microcontroller amplifier chips required sensor device fabrication successfully transfer printed fragile microelectromechanical systems based long wide thick high aspect ratio ultra thin pzt strain sensor onto flexible printed circuit fpc substrate etched wiring connected sensor wiring printing conductive paste using screen printer large ferroelectric polarization voltage hysteresis curves obtained even transfer printing process since output voltage corresponding magnitude strain developed sensor generated confirmed ultra thin sensors could integrated fpc substrate transfer screen printing techniques without damage pzt thin films shown epsilon dynamic strain sensitivity according resonant vibration stainless plate
study evaluate permeable pavement constructed topdown porous asphalt compacted natural grading base materials situ soil blended coarse sand geotextile crushed gravel permeable pavement paved field testing site installed rainfall simulation device control intensity rainfall coefficient permeability water content layer collected well volumetric water infiltration surface run test results show permeability surface layer degrading severely nine years service base subbase remained functional rainfall simulation performed permeable pavement retain water infiltration surface run measured respectively analysis flood peak present permeable pavement delay occurrence flood peak generated surface run ease quickly continuous infiltration
design implementation hybrid energy scavenging integrated circuit presented includes asynchronous self powered analog sensor data logger sdl unit mhz radio frequency programming interface sdl unit operates event based analog self powering technique energy sensing computation non volatile storage harvested directly signal sensed exploiting operational primitives inherent controlled hot electron injection mechanism sdl unit eliminates need voltage regulation energy storage adcs mcus rams commonly used traditional energy scavenging sensors remote programming data interrogation sdl unit performed using integrated mhz back telemetry interface interface consists instruction set digital command control unit based token ring architecture high voltage generator programming floating gate transistors front end unit communicating external reader show self powered design suitable integration electro capacitive transducers piezoelectric transducers generate open load voltages greater drive currents less measured results prototypes fabricated standard cmos process demonstrate consumes less self powering mode less power powering mode interrogation distance combining self powering powering show sensor experiences minimum time continuously monitor record level crossing statistics different attributes sensor signals
paper discusses grid interface challenges cern proposed compact linear colliders clic klystron modulators including power system optimisation modular multilevel converter evaluated candidate topology medium voltage grid interface along control method reducing impact klystron modulators electrical network
according social message model interpersonal judgments transactions judges convey important social messages individuals evaluate targets targets respond judgments less adaptive ways argue judges opinions emerge current concerns promote well foster group cohesion targets judgments best interpret meaning judgment receive understanding judge concerns competence judge qualities transaction suggest judges targets better able reason judgment process likely change behaviors adaptively people less able reason area
laboratory reactor physics systems behaviour psi epfl developing recent years new code system reactor analysis based openfoam objective supplement available legacy codes modern tool featuring state art characteristics terms scalability programming approach flexibility part project new solver developed eigenvalue transient solution multi group diffusion equations several features distinguish developed solver available codes particular object oriented programming ease code modification maintenance modern parallel computing capabilities use general unstructured meshes possibility mesh deformation cell wise parametrization cross sections arbitrary energy group structure addition solver integrated gen foam multi physics solver general features solver integration gen foam already presented previous publications present paper describes diffusion solver details provides overview new features recently implemented including use acceleration techniques discontinuity factors addition code verification performed comparison monte carlo results thermal fast reactor system elsevier ltd rights reserved
idiopathic pulmonary fibrosis ipf lethal lung disease treatment options poor prognosis emodin extracted chinese rhubarb found able alleviate bleomycin blm induced pulmonary fibrosis yet underlying mechanism remains largely unknown study aimed investigate effects emodin inflammation fibrosis blm induced pulmonary fibrosis mechanism involved rats results showed emodin improved pulmonary function reduced weight loss prevented death blm treated rats emodin significantly relieved lung edema fibrotic changes decreased collagen deposition suppressed infiltration myofibroblasts characterized expression alpha smooth muscle actin alpha sma inflammatory cells mainly macrophages lymphocytes moreover emodin reduced levels tnf alpha tgf beta heat shock protein hsp lungs blm treated rats vitro emodin profoundly inhibited tgf beta induced alpha sma collagen fibronectin expression human embryo lung fibroblasts helfs emodin also inhibited tgf beta induced smad stat activation indicating smad stat inactivation mediates emodin induced effects tgf beta induced myofibroblast differentiation results suggest emodin exert anti fibrotic effect via suppression tgf beta signaling subsequently inhibition inflammation hsp expression myofibroblast differentiation extracellular matrix ecm deposition elsevier ireland ltd rights reserved
cold drawn programmed shape memory polymer smp fibers show excellent stress recovery property promotes application mechanical actuators smart material systems full understanding thermomechanical damage responses fibers crucial minimize trial error manufacturing processes material systems work multiscale viscoplastic viscodamage theory developed predict cyclic mechanical responses smp fibers proposed viscoplastic theory based governing relations individual microconstituents establishes microscale state stress strain subphases microscale fields averaged micromechanics framework demonstrate macroscale constitutive mechanical behavior cyclic loss functionality smp fibers interpreted damage process herein cyclic loss stress recovery property calibrated identify state damage continuum damage mechanics cdm together thermodynamic consistent viscodamage theory incorporated simulate damage process developed coupled viscoplastic viscodamage theory provides excellent correlation experimental simulation results cyclic loading damage analysis work relies underlying physical facts accounts microstructural changes micro constituents established framework provides well structured method capture cyclic responses smp fibers utmost importance designing smp fiber based smart material systems doi
objective study conducted assess level knowledge influenza infection among health care workers secondary health care facility osogbo southwest nigeria methods structured questionnaire assessing participants knowledge swine influenza viruses mode transmission clinical criteria primary prevention indications emergency care care affected persons ongoing pandemic influenza hand delivered senior health care workers working hospital results mean age respondents years majority females television radio newspapers health workers internet main sources information influenza nearly felt source information disease inadequate half knew virus transmitted one person another majority identified correctly symptoms infected victims fever runny nose identified hand washing soap water mode preventing transmission felt infected person isolated knew oseltamivir zanamivir drugs treat multivariate linear regression analysis identified male sex internet source information knowledge prevention factors significantly associated high knowledge score current pandemic conclusion need provide comprehensive information health workers current pandemic
discharge untreated wastewater one general performances threatening local environment moreover urban rural regions increasingly confronting challenges towards managing access clean water supplies contemporarily growing interest development green buildings observed reflecting necessity creating environmentally responsive built environments main purpose sustainability green buildings mitigate negative impacts buildings respective lifecycle natural environment essential represent substantial impact green building evaluations inherent part future building policies creation healthy living environments nevertheless contemporary complex wastewater treatments process requires significant energy resources resulting elevated emission levels likewise diverse wastewater treatment practices may require considerable energy consumption deteriorating sustainability provisions consequently article proposes utilization hybrid membrane wastewater treatment techniques approach sustainable design green built environments elsevier ltd rights reserved
evaluation developed afb real time dynamic response experiment performed cable stayed bridge model response cable stayed bridge model measured using traditional wired system developed afb based usms experiment results showed compressed dynamic response acquired afb based usms matched significantly traditional wired system still carrying sufficient modal information cable stayed bridge therefore developed afb able reconstruct resample dynamic response wholly compressed response signal applied new kind measurement system wsn based structural health monitoring system secures economy efficiency published elsevier ltd
ability produce peak performance plays decisive role success athletes competitive contest situations levels appetitive competition motivation acm desire defeat opponent independent secondary reinforcing factors assessed professional female football soccer players premier regional leagues using club level measurement sport success furthermore influence social environments predominantly encouraging masculine competitive play behavior players perceptions gender role orientations investigated ninety female football players german premier league regional leagues participated age years questionnaires ascertaining acm self perceptions gender via gender role stereotypes childhood play behavior style upbringing utilized premier league athletes showed significantly greater inclination toward direct sporting confrontations almost variance acm premier regional league athletes determined modern upbringing style development gender roles corresponding classic female gender stereotypes results emphasize significance acm important facet competitive sports illustrate influence socialization athletic performance
training ethics fundamental higher education among faith based secular colleges universities regardless one academic major field study catholic colleges universities included moral philosophy theology applied ethics undergraduate curricula generations purpose investigation determine anything jesuit college psychology departments educate psychology majors regarding ethical issues survey method used assess psychology departments jesuits colleges universities united states total schools responded completed survey five schools reported offered course specifically ethics psychology three additional schools offered related courses eight offered ethics related courses one required majors take enrolled mental health forensic psychology tracks two schools ethics psychology course counted university core ethics requirement two others class met elective university ethics requirement psychology majors
body central many mindfulness based interventions body mindfulness defined observing body experiences consequence appreciating body experiences since psychometrically sound questionnaires available measure observing aspect body mindfulness scale specifically addresses appreciating aspect body mindfulness body mindfulness questionnaire bmq created study presents development psychometric evaluation bmq exploratory confirmatory factor analyses suggested two scales experiencing body awareness appreciating body awareness evidence reliability internal consistency retest reliability validity factorial validity construct validity sensitivity change reported findings suggest bmq valid reliable instrument allows assessment essential facets body mindfulness
climate change hugely important issue human facing sustainable development green building one solutions mitigate impacts climate change pervious concrete one type green material pervious concrete keep runoff rainwater water resource environment preserved heat island effects reduced general pervious concrete used pavement also employed coastal structures artificial fish reefs seawalls taiwan paper focused studying characteristics applying designed pervious concrete pavement seawall utility experimental results showed compression strength field specimen kgf exceed specifications normal concrete structure pervious concrete used study capacity penetrate water field permeability test simulated field site sec seawall made pervious concrete experimental results showed seawall reduce phenomena wave run comparing seawall made normal concrete specimens furthermore shown surface temperature pervious concrete fluctuates quicker normal concrete preliminary results study valuable serve useful reference designing constructing pervious concrete future
paper reviews challenges projects long drives installed microtunneling methods provides review state art equipment technology well specialized techniques minimizing penetration resistance limiting compressive stresses within jacked pipe string length pipe jacked using microtunneling methods depends number interrelated variable factors roughly categorized penetration resistance strength materials limitations microtunneling equipment installation feasibility include production efficiency cost containment specialized techniques improved technology safety personnel actual distance achievable given set site conditions optimized implementing state art equipment technology using range specialized techniques automated systems lubrication plants intermediate jacking stations steering controls intended improve production rates safety issues involve personnel entry pipeline increasing length north america witnessed microtunnel drive lengths increased however parts world longer pipe drives relatively common municipalities able make use long drive microtunneling technology realize increased benefits greater flexibility solve difficult problems locating shafts accommodating surface disruptions sensitive areas especially urban centers wetlands environmentally contaminated sites significant cost benefits may also realized reducing number expensive shafts needed install pipeline elsevier ltd rights reserved
media violence research mainly focused aggression effects far audiences thoughts violent portrayals actually confined aggressive fantasies study examines complex thought processes violent portrayals involve reflection meaning making truth seeking violence fact social reality conducted qualitative depth interviews participants different backgrounds including professions risk exposure violence media professionals interviewees general population interviews revealed three main categories reflective thoughts violent media content including thoughts truth value life world relevance psychological moral implications violence depicted participants also discussed unrealistic content features interfered meaning making
objective investigate concentration serum matrix metalloproteinase mmp active ankylosing spondylitis infliximab treatment evaluate whether mmp mmp associated clinical measures disease activity function method baseline sequential serum mmp mmp examined week infliximab treatment patients clinical sores evaluated asdas basfi basmi esr crp paired test spearman correlation analysis used statistic analysis results serum mmp mmp clinical scores including asdas basfi basmi esr crp patients significantly decreased treated infliximab weeks peripheral arthritis patients higher mmp level without patients contrastly without patients higher mmp level association found mmp esr crp asdas basfi mmp associated crp asdas basfi basmi weeks decrease mmp associated improvement asdas basfi esr crp basmi decline mmp correlated improvement asdas basmi crp thirty seven responders seven non responders according improvement asdas criteria week infliximab infusion responders higher baseline serum mmp non responders mmp conclusions serum mmp mmp decreased significantly active patients infliximab therapy decline associated improvement clinical syndromes infliximab responders higher baseline serum mmp mmp level infliximab non responders
propose novel approach observing cosmic rays ultra high energy repurposing existing network smartphones ground detector array extensive air showers generated cosmic rays produce muons high energy photons detected cmos sensors smartphone cameras small size low efficiency sensor compensated large number active phones show user adoption targets met network significant observing power highest energies elsevier rights reserved
background olmsted syndrome congenital dermatosis characterized palmoplantar keratoderma periorificial keratotic plaque trpv transient receptor potential vanilloid subtype encodes thermosensitive channel causative gene however molecular mechanism causes pathological development unclear objective aimed investigate molecular mechanisms underlying pathology perspective lipid metabolism methods comprehensive lipidomics microarray analyses conducted tissue samples non lesional skin area model rats rats wild type rats control results infiltration leukocytes eosinophils neutrophils increase fibrotic region detected unaffected skin area rats compared rats among lipid species examined levels lipoxygenase lox metabolites precursors anti inflammatory pro resolving lipid mediators dihydroceramides decreased fold rats compared rats consistent decreases lox metabolites expression levels genes encode loxs alox aloxb largely reduced conversely increased expression levels detected cxcl cxcl encode cytokines chemokines encode binding proteins implicated epidermal proliferation conclusion pro inflammatory state unaffected skin rats caused decreases lox metabolites increases cytokines chemokines may contribute pathogenesis japanese society investigative dermatology published elsevier ireland ltd rights reserved
depression involves dysfunction affective fronto limbic circuitry including prefrontal cortices several limbic structures including cingulate cortex amygdala hippocampus well basal ganglia major emphasis research etiology treatment mood disorders assess impact centrally generated top processes impacting affective fronto limbic circuitry present review shows peripheral bottom unipolar stimulation via visual auditory modalities well physical exercise modulates mood depressive symptoms humans animals activates central affective neurocircuitry involved depression proposed amygdala serves gateway articulating mood regulatory sensorimotor stimulation central affective circuitry emotionally labeling mediating storage emotional events long term memory since amelioration aggravation mood shown possible unipolar stimulation review suggests psychophysical assessment mood modulation multimodal stimulation may uncover mood ameliorative synergisms serve adjunctive treatment depression thus integrative review emphasizes relevance investigating optimal levels mood regulatory sensorimotor stimulation also provides conceptual springboard related future research
section model wind tunnel test currently main technique investigate flutter performance long span bridges study applying wind tunnel test results aerodynamic optimization still needed systematical parameters test principle bridge section model determined using three long span steel truss suspension bridges flutter critical wind different attack angles obtained section model flutter test unfavorable working condition tests investigate effects upper central stabilized plate lower central stabilized plate horizontal stabilized plate flutter performance main beam conducted according test results optimal aerodynamic measure chosen meet requirements bridge wind resistance consideration safety economy aesthetics last credibility results confirmed full bridge aerodynamic elastic model test flutter reduced wind speed long span steel truss suspension bridges stays approximately concluded reference investigation flutter performance future similar steel truss girder suspension bridges
objective purpose study assess features patient satisfaction scores radiologists using popular physician rating website materials methods patient reviews retrieved website ratemds listed radiologists cities population greater reviews included rating scores highest four categories staff punctuality knowledge helpfulness additional physician information obtained medicare files common words patient free text comments assessed statistical analyses performed results identified patient reviews radiologists four categories common score excellent second common score terrible scores far less frequent scores four categories highly correlated one another radiologists northeast scored significantly lower elsewhere staff punctuality radiologists attending designated top medical school showed nonsignificant trends toward lower scores helpfulness knowledge common words free text comments positive reviews caring knowledgeable professional negative reviews rude pain unprofessional common conclusion overall radiologists rated online patients score well reviews tended either strongly positive negative scores across various categories highly correlated suggesting halo effect radiologists recognize effect facility radiologist related factors influencing patients overall perceptions
intimate partner abuse ipa major social problem lead mental health conditions implicated female male homicide deaths hypothesized due distinct relationship structures power dynamics immersed varying sociocultural contexts victims male male female female female male dyads experience different patterns ipa objectives examine demographic clinical characteristics victims male victim male abuser female victim male abuser male victim female abuser female victim female abuser dyads compare patterns ipa reported victims groups subjects general population attempted internet based study english speaking subjects older years experienced ipa provided complete information analysis victims ipa screened specific methods abuse evaluated significantly educated groups experienced abuse age parent relative experienced physical abuse least physical abuse threats abuse front children reported least ipa patterns differ significantly presenting physical profile presenting least
active circuits arbitrary transfer characteristics current mode presented paper given circuits bayed multiple loop feedback structure namely follow leader feedback structure output summation modeling signal flow graph technique used modify transform structure current mode implementations multi output current differencing input transconductors cdta given verification illustration shown designed circuits simulated pspice snap resulting responses confirming theoretical assumptions
aims prognostic stratification patients idiopathic dilated cardiomyopathy idcm difficult task assessed additive value evaluation biomarkers inflammasome activation systemic inflammation long term risk stratification idcm patients methods results studied ambulatory idcm patients mean age years men nyha class median left ventricular ejection fraction lvef mean sodium meq median bnp median beta beta median median follow period months patients died underwent heart transplantation patients died underwent heart transplantation likely male nyha class iii atrial fibrillation lower lvef higher bnp levels beta levels differ significantly groups patients good bad prognosis beta levels vary significantly among either different nyha classes quartiles lvef multivariable model however beta strong independent predictor cause mortality log squared transformed values factors associated outcome male gender presence atrial fibrillation sodium concentration estimated time dependent roc curve multivariable model showed auc conclusions serum levels beta could useful predict long term outcome patients idcm
objectives study investigated effect menstrual cycle vocal fold vibratory characteristics young women using high speed digital imaging study examined menstrual phase effect five objective high speed imaging parameters two self rated perceptual parameters effects oral birth control use also investigated methods thirteen subjects prior voice complaints included study data collected three different time periods premenses postmenses ovulation course one menstrual cycle five subjects data collected two consecutive cycles six subjects oral birth control users high speed imaging data five objective parameters computed fundamental frequency fundamental frequency deviation harmonics noise ratio harmonic richness factor ratio first second harmonics supplemented two self rated parameters reflux severity index perceptual voice quality rating analysis included mixed model linear analysis repeated measures results results indicated significant main effects menstrual phase cycle birth control use analysis mean fundamental frequency fundamental frequency deviation harmonics noise ratio harmonic richness factor first second harmonics reflux severity index perceptual voice quality rating additionally interaction effects conclusions hormone fluctuations observed across menstrual cycle appear direct effect vocal fold vibratory characteristics young women voice concerns birth control use hand may influence spectral richness vocal fold vibration
paper propose efficient secure key establishment protocol tailored wireless mesh networks protocol based identity based key establishment without utilization trusted authority private key generation instead task performed collaboration mesh nodes number users exceeding certain threshold form coalition generate private keys network users performed simulative performance evaluation order show effect threshold value network size total number nodes latency key establishment success percentage user private key generation results reveal trade resiliency efficiency increasing threshold value also increases resiliency network negatively effects latency success percentage threshold values smaller minimum mesh nodes least user private keys computed within min also discuss security protocol show protocol secure outsider malicious insider semi honest adversaries elsevier rights reserved
background coronal alignment important factor function longevity total knee arthroplasty tka coronal bowing lower extremity common among asians may pose risk malalignment lower leg malposition component hypothesis hypothesized coronal bowing risk malalignment lower leg malposition femoral tibial components navigation tka beneficial patients coronal bowing investigated incidence femoral tibial bowing patients treated tka compared radiographic parameters navigation group conventional group additionally influence coronal bowing radiographic parameters investigated materials methods enrolled patients knee osteoarthritis bilateral simultaneous tkas patients underwent tka use computer tomography free navigation one knee conventional tka contralateral knee preoperative coronal bowing measured subjects divided subgroups bowing group non bowing group lateral bowing expressed plus medial bowing expressed minus various radiographic parameters including coronal bowing lower leg alignment component position outliers compared navigation group conventional group results femoral bowing varied degrees degrees average degrees tibial bowing varied degrees degrees average degrees femoral component placed properly navigation group number outlier regarding coronal femoral component angle femoral mechanical axis cases bowing group cases non bowing group discussion conclusion coronal femoral bowing important effect femoral bone cut tka navigated tka consistent conventional tka aiding proper alignments femoral component elsevier masson sas rights reserved
background antibiotic use early life linked disruptions microbiome changes disturb immune system development differences observed microbiota children without allergies studies antibiotic use allergic disease objective evaluated associations early life antibiotic use subsequent occurrence food allergy allergies childhood using electronic health record data methods used longitudinal data children age years geisinger clinic electronic health record conduct sex age matched case control study evaluate association antibiotic use milk allergy non milk food allergies allergies outcome estimated conditional logistic regression models adjusting race ethnicity history medical assistance mode birth delivery models repeated separately penicillins cephalosporins macrolides results milk allergy cases non milk food allergy cases allergy cases children three antibiotic orders greater odds milk allergy odds ratio confidence interval non milk food allergy allergies compared children antibiotic orders associations strongest younger ages differed antibiotic class conclusions clinical relevance observed associations antibiotic orders allergic diseases providing evidence potentially modifiable clinical practice associated paediatric allergic disease differences antibiotic class explored knowledge could inform paediatric treatment decisions
inhibition beta secretase bace currently main pharmacological strategy available alzheimer disease qsar qsar analysis cyclic sulfone hydroxyethylamines inhibitors secretase carried using hologram qsar hqsar comparative molecular field analysis comfa comparative molecular similarity indices analysis comsia methods best model based training set generated hqsar value value comfa value value comsia value value order gain understand vital interactions cyclic sulfone hydroxyethylamines protease analysis performed combining comfa comsia field distributions active sites bace final qsar models could helpful design development novel active bace inhibitors elsevier ltd rights reserved
industrial waste heat may one answers future energy demands depending temperature industrial waste heat may used produce electricity meet cooling heating demands different temperature levels however order estimate influence waste heat may future energy systems magnitude industrial waste heat different countries need estimated germany far top analyses waste heat potential exist using key figures derived studies countries paper first bottom approach estimating industrial waste heat potential germany presented approach algorithm evaluate test mandatory emission report data german production companies developed second step round data sets evaluated calculate conservative lower boundary value industrial waste heat conservative lower boundary based collected data german industry waste heat volume evaluated industrial fuel consumption results used derive key figures missing share data approximated
adaptive optics system proportion integration differentiation pid controller widely used correcting wave front controller strictly dependent response model deformable mirror paper novel wave front correction method proposed method combining fuzzy control pid control depend response model deformable mirror based rapid wave front reconstruction wave front evaluation indexes extracted reconstructed wave front employed input fuzzy controller pid controller thus model response matrix deformable mirror required actuator deformable mirror corresponds independent fuzzy pid controller designing fuzzy controller including fuzzy rule base selection fuzzy reasoning three parameters pid controller proportional integral differential adjusted automatically high rapid dsp hardware platform constructed verify method test results show method used correct diffraction limit multiplication factor beta light spot basically traditional pid control stability better model need calibrate deformable mirror installation deformable mirror easier
taste preferences health concerns play important roles determining eating attitudes thus influencing food choices disordered eating attitudes common among women lead development maintenance eating disorders attitudes toward health taste food among patients comparison non clinical women well known knowledge could improve eating interventions study compared taste preferences health concerns women diagnosis bulimia nervosa women non clinical sample participants completed health taste attitude scale htas using analysis covariance compared htas scores patients college students risk behaviors assessed eating attitudes test identified non clinical sample therefore excluded comparison patients non clinical sample compared patients scored higher htas taste domain pleasure subscale whereas patients scored higher htas health domain light product interest subscale based data eating attitudes women non clinical sample related taste pleasure whereas women concerned adopting diet regarded healthy thus increasing interest light products therefore taste health concerns must considered nutrition interventions women general prevention treatment determinants food choice elsevier ltd rights reserved
surge tank provided secondary sodium circuit sodium cooled fast reactors sfr protect secondary sodium circuit components pressure surges due sodium water reaction steam generator pressurized argon gas inside surge tank sodium act cushion absorb pressure surges entrainment argon gas sodium due free level fluctuations turbulence etc cause operational difficulties reactor necessary develop effective gas entrainment mitigating devices keeps sodium free surface calm development experiments difficult time consuming therefore cfd model surge tank developed predict surge tank hydraulics validated experiments velocity measurement model different directions different elevations carried using ultrasonic velocity profiler uvp
background kingdom swaziland following introduction national family planning programme witnessed insufficient scientific publications contraceptive practices country despite documented high fertility rates low contraceptive prevalence rates study conducted understand practices potential determinants contraception among swazi women requested emergency contraception methods data collected period one month analysed using simple descriptive analysis summarise data bivariate analysis determine relevant factors associated use contraception results majority participants use contraceptives reasons given using contraception previously ranged medical conditions sexually active widely used contraceptives male condoms injectable hormones combined oral contraceptives least popular implants post coital pills knowledge contraceptives came mainly health facilities peers mass media parents least consulted sources high percentage aware sexually transmitted diseases stds male female condoms best forms protection stds demographic socio economic variables significantly related use contraceptives conclusion study established majority participants used form contraception also delayed sexual debut age years observed changes increased contraceptive use later age sexual debut could associated increased levels education participants predominant relaxed approach protestants zionists usually tolerant contraception recommendations based findings study would assist planning implementation future family planning programmes study serves foundation
main issue higher education czech republic relating mechanical engineering currently lack opportunities students acquire practical knowledge experience field studies moreover engineering companies czech republic often reluctant share knowhow universities meaning study machine design isolated practice engineering companies one way deal issues improve different aspects teaching technical subjects order improve quality efficiency comprehensibility attractiveness machine design faculty mechanical engineering university west bohemia fme launched machine design teaching enhancement project tep whose goal provide students academics fme quality learning materials learning materials concerned teaching computer aided engineering cae systems developed part tep step step learning materials promote self study make learning cae systems much easier students another part tep concerned developing new concept project based learning materials based interactive cae models learning materials developed academics cooperation local engineering companies software developers paper presents learning materials advantages students academics fme
explicit tests social cognition revealed pervasive deficits schizophrenia less known automatic social cognition schizophrenia used spatial orienting task investigate automatic shifts attention cued another person eye gaze patients controls central photographic images face eyes shifted left right looking straight ahead preceded targets appeared left right cue examine automatic effects cue direction non predictive target location cue target intervals non social control trials arrows replaced eye gaze cues groups showed automatic attentional orienting indexed faster reaction times rts arrows congruent target location across cue target intervals similar congruency effects seen eye shift cues intervals patients showed significantly larger congruency effects driven delayed responses incongruent target locations short cue target intervals neither group showed faster rts congruent incongruent eyeshift cues patients significantly slower detect targets direct gaze cues findings conflict previous studies using schematic line drawings eye shifts found automatic attentional orienting reduced schizophrenia instead data indicate patients display abnormalities responding gaze direction various stages gaze processing reflected stronger preferential capture attention another person direct eye contact initial stages gaze processing difficulties disengaging gazed location shared attention established
adding number computing nodes common approach achieving higher performance parallel computing system however constraint fixed system architecture fixed algorithm structure difficult improve performance parallel computing extending scale absolutely realize extension fixed structure analyze key factors architecture parallel task affect scalability use weighted graph model architecture well parallel task especially focusing case architecture graph parallel task graph homogeneous propose extension method graph similarity case architecture graph parallel task graph heterogeneous critical path unchanged scaling method proposed actually two extending methods change graph structure adjust node weight edge weight relevant graph furthermore mathematical derivation conclusions new scaling methods drawn finally order verify effectiveness simulative experiments conducted platform simgrid experimental results show proposed methods realize iso speed efficiency extension guide practical extensions parallel computing
published concurrent data structures avoid locking provide fairness guarantees allow processes access data structure complete operations arbitrarily many times trying process complete single operation behavior prevented enforcing fairness however fairness requires waiting helping helping techniques often complex memory consuming furthermore known possible automatically transform every data structure non blocking implementation corresponding data structure addition satisfies weak fairness requirement mean enforcing fairness best use locks answer negative show possible automatically transfer non blocking wait free data structure similar data structure satisfies strong fairness requirement without using locks limited waiting fairness require process initiate complete two operations given resource process kept waiting resource approach allows many processes possible access shared resource time long fairness preserved achieve goal introduce solve new synchronization problem called fair synchronization solving new problem enables add fairness existing implementations concurrent data structures transform solution mutual exclusion problem fair solution elsevier inc rights reserved
background varenicline efficacious medicine smoking cessation little known characteristics varenicline users study examined characteristics first time naive varenicline users finland compared previously used pharmacotherapy trying pharmacotherapy first time methods cross sectional survey conducted finnish community pharmacies february january pharmacy customers purchasing varenicline starter package first time ever asked complete questionnaire participate structured interview conducted pharmacist identical questions questionnaire included questions demographic characteristics smoking habits previous cessation attempts factors associated varenicline use results altogether people completed survey majority daily smokers history years regular smoking strong strong nicotine dependence half participants trying pharmacotherapy first time demographic characteristics smoking habits similar first time previous users medications health centers occupational health care clinics common sources varenicline prescriptions majority participants received prescription varenicline mentioning desire quitting physician conclusions considering relatively large proportion naive medicine users among new users varenicline smokers previously reluctant quit smoking use pharmacological interventions perhaps unaware options may interested attempting cessation varenicline participants made initiative discuss smoking physician led varenicline prescribing suggests physicians may satisfactorily recognize patients nicotine dependence desire quit actively support patients smoking cessation
translation biomaterial based nanoparticle formulations clinic faces significant challenges including efficacy safety consistency scale manufacturing stability long term storage continuous microfluidic fabrication polymeric nanoparticles potential alleviate challenges associated manufacture offering scalable solution clinical level production poly beta amino esters pbae class biodegradable cationic polymers self assemble anionic plasmid dna form polyplex nanoparticles shown effective transfecting cancer cells specifically vitro vivo demonstrate use microfluidic device continuous scalable production pbae dna nanoparticles followed lyophilization long term storage results improved vitro efficacy multiple cancer cell lines compared nanoparticles produced bulk mixing well comparison widely used commercially available transfection reagents polyethylenimine lipofectamine characterized nanoparticles using nanoparticle tracking analysis nta show microfluidic mixing resulted fewer dna free polymeric nanoparticles compared produced bulk mixing wiley periodicals inc
hydrodynamic parameters identified firstly predicting soil water loss specific issues objectives laboratory simulation scouring experiments conducted different gravel contents flow discharges slopes based field investigation achieved suitable parameter predicting soil water loss simulation landslide deposit slope wenchuan earthquake area china results showed gravel content always threshold controlled flow shear stress tau stream power omega increased decreased different flow discharges unit stream power unit flow energy decreased gravel contents increased ratio manning coefficient flow depth higher fine sediments gravels without gravels flow discharge consistent effects hydrodynamics ordered min tau suitable parameter predicting soil water loss considering degree reliability even though omega also significant positive power function soil water loss could describe hydrodynamics soil water loss alternative parameter predicting soil water loss results provide useful information soil water loss prediction landslide deposits
investigate strong stabilisation wind turbine tower model plane turbine blades comprises nonuniform nasa spacecraft control laboratory experiment scole system two mass drive train model gearbox control input torque created electrical generator using strong stabilisation theorem class impedance passive linear systems bounded control observation operators show wind turbine tower model strongly stabilised control static output feedback angular velocities nacelle generator rotor
paper reviews condensed form historical perspective various methods treating simulating turbulence effects hydraulic flows highlighting main characteristic features turbulence role plays hydraulics necessarily brief overview given main methods used hydraulic flow calculations dealing turbulence effects empirical relations methods solving reynolds averaged navier stokes rans equations aid statistical turbulence models direct numerical simulations dns large eddy simulations les brief comments made historical development different methods rans dns les methods application examples presented details individual methods application examples reader directed extensive literature
paper deals algorithm optimize efficiency induction motors used electrified powertrains battery electric hybrid vehicles drivetrain concepts necessary design electric drives high efficiency order maximize driving range performance algorithm part holistic design process presented well shown efficiency maps generated created way different control strategies influence drive efficiency therefore efficiency analyses two different induction machines field oriented rotor frequency control presented compared
context chemokine ligand ccl suggested play role development pulmonary fibrosis macrophages thought main source ccl effect pirfenidone anti fibrotic agent idiopathic pulmonary fibrosis expression ccl macrophages warrants investigation objective purpose study investigate effect pirfenidone expression ccl macrophages materials methods cells differentiated macrophages phorbol myristate acetate stimulated recombinant induce production ccl cells treated pirfenidone mrna protein levels ccl measured reverse transcription polymerase chain reaction enzyme linked immunosorbent assay respectively effects pirfenidone receptor expression stat activation investigated jak kinase activity measured using lyte kinase assay results pirfenidone significantly suppressed expression ccl cells treated concentrations pirfenidone affect expression components selective stat inhibitor suppressed ccl expression pirfenidone suppressed stat phosphorylation although effect pirfenidone less marked lyte kinase assay showed reduction activities jak jak tyk pirfenidone conclusion pirfenidone suppresses ccl expression macrophages effect thought attributed partly inhibition stat phosphorylation
resonant poles lcl filters may challenge entire system stability especially digital controlled pulse width modulation pwm inverters order tackle resonance issues many active damping solutions reported instance notch filter employed damp resonance notch frequency aligned exactly resonant frequency lcl filter however parameter variations lcl filter well time delay appearing digital control systems induce resonance drifting thus break alignment possibly deteriorating original damping paper effectiveness notch filter based active damping first explored considering drifts resonant frequency revealed resonant frequency drifts away nominal value phase lead lag introduced notch filter may make fail damp resonance specifically phase lag make current control stable despite resonant frequency drifting grid current fed back contrast case inverter current feedback control influence phase lead lag active damping dependent actual resonant frequency accordingly paper notch frequency designed away nominal resonant frequency tolerate resonance drifting proposed robust active damping simulations experiments performed three phase grid connected pwm inverter verify effectiveness proposed design robust active damping using digital notch filters
context black patients likely white patients die intensive care unit life sustaining treatments differences patient surrogate provider communication may contribute phenomenon objectives test whether hospital based physicians use different verbal nonverbal communication black white simulated patients surrogates methods conducted randomized factorial trial relationship patient race physician communication using high fidelity simulation using combination probabilistic convenience sampling recruited hospital based physicians western pennsylvania completed two encounters prognostically similar critically terminally ill black white elders identical treatment preferences conducted detailed content analysis audio video recordings encounters coding verbal emotion handling shared decision making behaviors nonverbal behaviors time interacting patient surrogate open closed posture touching patient physical proximity used paired test compare subjects summed verbal nonverbal communication scores black patient compared white patient results subject physicians verbal communication scores differ patient race black white value however nonverbal communication scores significantly lower black patient white patient black white value conclusion small regional sample hospital based physicians similar verbal communication behaviors discussing end life care otherwise similar black white patients exhibit significantly fewer positive rapport building nonverbal cues black patients american academy hospice palliative medicine published elsevier inc rights reserved
last decade share renewable energy sources energy mix risen significantly many countries large scale integration intermittent energy sources constitutes major challenge power grid crucial building block successful transformation today energy systems use energy storage either located renewable energy sources grid level end present model basis markov decision process short term trading intermittent energy production located energy storage model explicitly considers time lag trade delivery energy characteristic energy markets storage representation includes asymmetrical conversion losses asymmetrical power self discharge stochastic production market prices represented arima processes producer may also undertake price arbitrage purchasing energy market prices comparatively low regarding solution model develop several intuitive easily interpretable decision rules readily applied practice extensive numerical study based real world data confirms excellent performance rules comparison sophisticated approximate dynamic programming algorithm adapted literature elsevier ltd rights reserved
rapid expansion evolution epigenetics core scientific discipline raised new questions endogenous environmental factors inform mechanisms biological form function regulated existing proposed animal models used epigenetic research targeted myriad health disease end points may acute chronic transgenerational nature initiating events outcomes may extend across entire lifespan elicit unanticipated phenotypes particular concern institutional animal care use committees iacucs dynamics plasticity epigenetic mechanisms produce effects consequences manifest differentially within discreet spatial temporal contexts including prenatal development stem cells assisted reproductive technologies production sexual dimorphisms senescence others many dietary nutritional interventions also shown significant impact biological functions disease susceptibilities altered epigenetic programming environmental chemical toxic therapeutic psychosocial stressors used animal studies elicit epigenetic changes become extreme raise iacuc concerns well proper care research animals involved epigenetics research rapidly becoming integral part search mechanisms every major area biomedical behavioral research foster continued development new animal models iacuc perspective care must taken acknowledge particular needs concerns created superimposition epigenetic mechanisms diverse fields investigation ensure proper care use animals without impeding scientific progress
scholars consider latin american migration toward europe case study feminization international migration however studies focused second generation girls beginning gender intergenerational approach paper stresses agency role played reunified teenage daughters ecuadorian migrants ecuador well southern europe discussion based two transnational ethnographic studies conducted ecuadorian children aged families two medium sized southern european cities genoa seville ecuador first paper shows girls carry essential task caretakers transnational household point origin destination despite responsibilities show higher commitment school terms time spent school results secondly analyses girls negotiate role inside outside family challenging parents moral sexual control strategies results disclose identity struggle everyday lives girls participate migration project transnational family simultaneously implement practices resistance renegotiation addressing traditional division gender roles
first known exact solutions derived free vibration thick moderately thick functionally graded rectangular plates least one pair opposite edges simply supported basis family two dimensional shear normal deformation theories variable order boundary value problem first expressed compact unified form invariant respect order kinematic theory levy method applied compact form yields set governing equations written terms invariant matrices appropriately expanded according order plate model resulting equations put state space representation frequency values finally obtained substituting general solution state equation set boundary conditions solving related homogeneous system discussing way recovering thickness modal displacement stress distribution point plate effective elastic properties graded plate computed numerical results presented using various higher order theories comparisons exact three dimensional two dimensional approaches provided two constituents metal ceramic plates new exact results functionally graded plates six combinations boundary conditions also obtained useful valuable sources validating approaches approximate methods elsevier ltd rights reserved
background vitamin deficiency associated adverse health outcomes examined genetic environmental determinants serum childhood methods study sample consisted healthy australian children predominantly caucasians provided venous blood sample parental interview conducted skin phototype anthropometry measures assessed concentrations measured selective solid phase extraction capillary liquid chromatography tandem mass spectrometry concentrations deseasonalised relevant remove effect month sampling results deseasonalised log concentrations moderately correlated following predicted uvr weeks interview natural skin eye colour height vitamin allelic metabolism score following predicted lifetime sunburns vitamin allelic synthesis score overall variation could explained accounting concentrations higher uvr weeks interview vitamin allelic metabolism score predicted concentrations conclusions environmental factors genetic factors contributed vitamin metabolite concentrations intriguing finding higher ambient uvr contributed higher accounting concentrations requires evaluation
gram negative bacterium riemerella anatipestifer important waterfowl pathogen causing major economic losses duck producing industry however little known virulence factors mediate pathogenesis anatipestifer infection study raym raym predicted form two component signaling system tcs bioinformatics analysis tcs highly conserved across flavobacteriaceae mutant delta strain constructed investigate role raym raym tcs anatipestifer virulence gene regulation median lethal dose delta found cfu equivalent avirulent bacterial strains bacterial abundances delta strain heart brain liver blood spleen significantly lower wild type anatipestifer strain pathological analysis using hematoxylin eosin staining showed compared wild type mutant delta strain caused significantly less virulence infected ducklings rnaseq real time pcr analysis indicated raym raym tcs phop phor system novel type tcs gram negative bacteria tcs also found global regulator expression anatipestifer genes regulated genes regulated delta strain similar genes demonstrated differential expression summary reported first phop phor tcs identified gram negative bacterium demonstrated involved virulence gene regulation anatipestifer
demand infrared transmitting materials grown steadily several decades markets realize new applications longer wavelength sensing imaging growth come demand new challenging material requirements satisfied crystalline products alone chalcogenide materials unique physical thermal optical properties found acceptance designers fabricators meet demands material perfect every regard chalcogenides exception cause concern relatively low fracture toughness propensity bulk material fracture condition amplified traditional subtractive manufacturing processes employed form processing leaves behind micro fractures sub surface damage act propagation points local catastrophic failure material precision lens molding subtractive process result micro fractures sub surface damage created results stronger component one produced traditional methods new processing methods also identified result even stronger surface resistant breakage without need post processing techniques may compromise surface integrity paper discuss results achieved process lens molding development edmund optics result measurably stronger chalcogenide components various metrics examined data presented quantifies component strength different manufacturing processes acute limb ischemia one common peripheral arterial disease surgical restoration blood flow often results ischemia reperfusion injury previous study revealed inflammation intensity arterial tissue characterized expression high mobility group box protein hmgb contrary fluctuation hemodynamics reperfusion limbs rat model study meant clarify role hmgb process laser doppler perfusion imaging evaluated limb hemodynamics mean max perfusion unit femoral arterial tissue collected molecular biology examination results revealed hmgb promoted vascular structure remodeling vasomotor dysfunction acute characterized degradation collagenous fibers disruption elastic lamellae intensive inflammation phenotype transfer smooth muscle cells blockade hmgb preserved vascular homeostasis improved pus meanpu maxpu elevated expression tnf alpha icam vcam mmp mmp alpha actin correlated hmgb positively conclusion hmgb promoted vascular remodeling dysfunction via initiating inflammation cascade blockade hmgb would preserve vascular homeostasis facilitate blood perfusion ischemic limb elsevier inc rights reserved
controllable synthesis surface modification tio crystals specific exposed facets using fluoride shape directing agent drawn great deal attention photocatalytic field exposed facets surface ions known great influence photocatalytic performance tio crystals two factors usually considered discussed separately investigated influence surface ions carrier migration surface ions present anatase tio crystals predominant facets using photo oxidation photo oxidation probe reactions observed remarkable synergistic effect facets surface ions photogenerated hole migration facets provide hole trapping sites electrostatic effect surface anions attract accelerate holes migration facets synergistically promote electron hole pair separation thus significantly enhance photo oxidation activity however synergistic effect detected facets surface ions finding provides new insight photogenerated charge migration fluorinated tio specific exposed facets elsevier rights reserved
stream experience unfolds memory system rapidly transforms current inputs long lasting meaningful memories putative neural mechanism strongly influences input elements transformed meaningful memory codes relies ability integrate existing structures knowledge schemas however yet clear whether schema related integration neural mechanisms occur online encoding current investigation examined encoding dependent nature phenomenon humans showed actively integrating words congruent semantic information provided category cue enhances memory words increases false recall memory effect active integration congruent information robust even interference task occurring right encoding word list addition via electroencephalography show separate studies onset neural signals successful encoding appeared early similar encoding congruent words neural signals successful encoding congruent incongruent information followed similarly similar later suggests earlier neural response contributed memory formation propose encoding events congruent readily available contextual semantics trigger accelerated onset neural mechanisms supporting integration semantic information event input faster onset would result long lasting meaningful memory trace event time make difficult distinguish plausible never encoded events related false memories
uranus together neptune solar system belongs class planets called ice giants never explored using dedicated mission mission explore ice giants one highest priority missions nasa paper present new unique multi probe multi planet spacecraft explore two outer planets saturn uranus mission concept addresses high priority science goals saturn uranus set forth national research council planetary sciences decadal survey visions voyages planetary science decade growing importance understanding evolution role ice giants extra solar planetary systems makes uranus pertinent scientific target mission concept employs space launch system deliver orbiter uranus using ballistic saturn uranus trajectory time flight years baseline mission concept includes two atmospheric entry probes one deployed saturn another uranus prior impulsive orbit capture payload nine remote sensing situ plasma instruments onboard orbiter support broad array investigations nominal year science mission addition baseline concept system trade studies conducted explore advantages aerocapture use space launch system based results trade studies preferred point design within constraints nasa flagship program launched late neural network model using analogy based data developed estimate mission cost found billion cospar published elsevier ltd rights reserved
background hereditary angioedema normal inhibitor levels hae associated factor xii mutation subjects however role mutation pathogenesis angioedema unclear objective sought evidence abnormalities pathways bradykinin formation bradykinin degradation plasma patients hae without mutation methods bradykinin added plasma rate degradation measured using elisa plasma autoactivation assessed using chromogenic assay kallikrein formation plasminogen activator inhibitors pais also measured means elisa results pai levels varied mean control subjects mean patients hae factor xii mutation samples mean patients hae without factor xii mutation samples pai levels varied mean control subjects mean patients hae without factor xii mutation autoactivation dilution abnormally high patients hae subcategory could corrected supplemental inhibitor bradykinin degradation markedly abnormal patients hae normal remaining patients conclusions bradykinin degradation normal patients hae studied contrast marked abnormality pai levels patients hae seen patients inhibitor deficiency pai levels varied considerably statistically significant difference seen link excessive fibrinolysis bradykinin generation estrogen dependent suggested
investigate whether association braak neurofibrillary tangle nft stage clinical mri features definite primary age related tauopathy part analysed cases braak nft tangle stage thal phase beta amyloid present twenty nine female median age death years iqr years fifteen tdp positive tdp stage argyrophilic grain disease three alpha synuclein positive lewy bodies tdp inclusion present rare predominantly perivascular tdp three showed moderate number inclusions also hippocampal sclerosis neuronal intranuclear inclusions fine neurites region hippocampus four cases apolipoprotein epsilon apoe allele significant correlation age death braak nft stage accounting age clinical examination significant associations braak nft stage wais block design trail making tests higher braak stage associated poorer performances thirty cases completed antemortem volumetric head mri two separate mri analyses revealed association higher braak nft stage grey matter atrophy head left hippocampus significant clinical radiologic associations tdp findings study demonstrate aggregated tau distribution associated poorer cognitive performance well atrophy absence beta amyloid findings support parcellation definite part useful construct relatively low frequencies apoe tdp lewy bodies hippocampal sclerosis rarity morphology tdp lesions noted contrasts typically observed alzheimer disease old
whereas data available late smoking relapse among adult quitters none teen quitters study year follow teen quitters collected retrospectively data extent timing relapse found even strictly defined quit six months prolonged abstinence one year substantial relapse occurred early late majority relapses occurred year interval quit findings implication need research relapse process teen quitters need develop interventions teens adults prevent early late relapse published elsevier ltd
objectivesdeep brain stimulation dbs subthalamic nucleus stn improves motor symptoms advanced parkinson disease stn dbs may also affect emotion possibly impacting parallel limbic cortico striatal circuit objective study investigate changes prefrontal cortical activity related dbs emotion induction task materials methodswe used near infrared spectroscopy monitor prefrontal cortex hemodynamic changes emotion induction task seven dbs patients tested sequentially stimulation stimulation states dopaminergic medication patients watched series positive negative neutral videos general linear model used compare prefrontal oxygenated hemoglobin concentration dbs states resultsdeep brain stimulation correlated prefrontal oxygenated hemoglobin changes relative stimulation state response positive negative videos changes specific emotional stimuli seen neutral stimuli conclusionsthese results suggest stn stimulation influences prefrontal cortical representation positive negative emotion induction
abstract general theory control engineering fundamental traditional teaching methods course facing difficulties teachers find difficult teach students feel hard learn long time order improve teaching efficiency quality course virtual experiment method applied teaching practice course new method relies matlab simulink virtual experiment platform realize combination real experiment virtual experiment furthermore provides open self learning platform students experimental study teaching course three years carried using equal group test method verify effect virtual experiment results show virtual experiment play good role course teaching significantly improve teaching effect also promote students professional quality ability independent innovation
hexanucleotide repeat expansions corf gene causally associated frontotemporal lobar dementia ftld amyotrophic lateral sclerosis als physiological function normal corf protein remains unclear study characterized subcellular localization corf processing bodies bodies recruitment stress granules sgs upon stress related stimuli gain function loss function experiments revealed long isoform corf protein regulates assembly crispr cas mediated knockdown corf completely abolished formation negatively impacted expression associated proteins tia hur accelerated cell death loss corf expression compromised cellular recovery responses removal stress additionally mimicking pathogenic condition via expression hexanucleotide expansion upstream corf impaired expression corf protein caused abnormal accumulation rna foci led spontaneous formation sgs study identifies novel function normal corf assembly sheds light mutant expansions might impair formation cellular stress related adaptive responses
classical electrical circuits consist resistors capacitors governed integer order model circuits may called fractance represents electrical element fractional order impedance therefore fractional order derivative important study dynamical behaviors circuits paper extends classical coupled duffing circuits cover new fractional order duffing system consisting two identical periodic forced circuits coupled linear resistor fundamental resonance responses various paired unpaired fractional orders investigated detail using harmonic balance combination polynomial homotopy continuation approximate solutions high degree accuracy steady state response sought exist different shapes frequency versus response excitation amplitude versus response curves various fractional orders multiple valued solutions nonclassical bifurcations observed analytically verified numerically influence coupling intensity fundamental resonance response also examined new contributions include innovative introduction fractional order coupled duffing circuits explicit integration fractional order linear consideration higher harmonics improve nonlinear solutions lower harmonics without increasing computational complexity
decrease use fossil fuels face energetic demand integration renewable energy necessary step part renewable energy supplied production electricity photovoltaic panels windfarms massive use intermittent energies lead overproduction periods consequently need convert surplus electricity storable form energy power gas ptg technology consists using electricity convert water hydrogen electrolysis synthetize methane carbon dioxide hydrogen techno economic life cycle assessment methane production via combination anaerobic digestion ptg technology applied sewage sludge valorization process studies equipment design addressed considering already available technologies sensitivity analyses done biogas upgrading technologies electricity prices annual operation time composition electricity mix also comparison ptg direct injection appears electricity expensive longer operation time methanation process must competitive injection methane biogas reduction electricity consumption electrolysis step decreases production costs even current context feature adapted conditions ensure economically viable chain evolution energetic context next years well expected technological improvements contribute overall cost reduction environmental point view continuous ptg generates greenhouse gases direct injection intermittent operation use renewable electricity significantly reduce ghg emissions endpoint impacts perspective impact continuous ptg higher biogas upgrading much lower fossil energy future development low electricity consumption electrolysis process integration renewable credits valorization increase competitiveness technology published elsevier ltd
recent literature indicates potential community based obesity prevention programmes endeavour reduce prevalence obesity developed nations considerable suggestion advocacy come theoretical standpoints little known actual practical application type multi component health promotion programme article explores experiences implementation stakeholders large community based obesity prevention programme facilitated national health service care trust north east england three stakeholder groups senior health officials public health workers community members administrated experienced programme since conception provide perspectives aspects local delivery receipt semi structured interviews focus groups conducted stakeholders participants total participants felt three broad aspects shaped constrained delivery receipt programme namely partnership working integration services quality issues data indicated taken time establish working partnerships multi agencies involved community based obesity programme strategic management would aid processes communication collaboration agencies also local community involved administration delivery participation interventions programme secondly way programme justified sustained reviewed intention using suitable evaluative framework tool monitoring purposes
paper presents wavelet based linearization method evaluating aerodynamic damping wind turbine operation method used estimate aerodynamic damping solely actual measurements dynamic response operating wind turbine due ambient excitation air turbulence control forces based response measurements generalised displacement velocity acceleration vectors related given aeroelastic model available aeroelastic code estimated state observer external generalised load vector depending generalised velocity vector obtained aeroelastic code next external generalised load vector linearized two parts quasi static load vector independent generalised velocity vector first order term linearly proportional velocity vector indicating aerodynamic damping matrix filtering technique applied evaluate quasi static load vector actual measurements structural stiffness force made product time dependent stiffness matrix estimated generalised displacement vector finally time dependent aerodynamic damping matrix evaluated wavelet analysis time step unlike inverse based approaches wavelet based method avoid calculating inverse velocity vector covariance matrix singular proposed method illustrated reduced dof aeroelastic model used mimic situ response measured wind turbine elsevier ltd rights reserved
abuse psychostimulant methamphetamine associated substantial costs limited treatment options understand mechanisms lead abuse animal models voluntary drug intake crucial aimed develop protocol study long term non invasive voluntary intake mice mice maintained home cages allowed daily access attached tunnel leading test chamber nebulized available restated went nebulizing chamber self administered inhalation protocol compared injected imposed exposure nebulized series seven experiments established concentration nebulized motor activity increases following voluntary intake resembled following injection imposed inhalation found mice regulated exposure self administering shorter durations concentrations nebulized increased mice acquire available repeatedly running nebulizing chamber brief bouts intake exposure nebulized elevated plasma levels limited evidence sensitization locomotor activity finally blocking access wheel affect time spent nebulizing chamber conclude administration nebulization effective route self administration new protocol represents promising tool examining transitions first intake long term use behavioral neural consequences non invasive protocol
paper presents linear programming model solution time cost tradeoff problem although several analytical models developed time cost optimization tco many mainly focused projects contract duration fixed optimization objective therefore restricted identify minimum total cost another group primarily focused project duration minimization model presented considers scheduling characteristics ignored prior research new formulation variability funding uncertainty project duration considered together chance constrained programming used incorporate variability funding quantified coefficient variation financial feasibility expressed stochastic constraint transformed deterministic equivalent prespecified confidence level also project duration uncertainty incorporated model applying program evaluation review technique pert scheduling uncertainty quantified coefficient variation prespecified confidence level system objective function minimizing direct cost group constraints solved using lindo software two examples conducted demonstrate model performance contributions four scenarios adopted solving example problems reflect effect funding variability time uncertainty project cost duration results revealed confidence level variability funding versus omitting would increase direct cost approximately prespecified project deadline also variability time versus omitting would increase duration range approximately prespecified direct cost hand considering variability funding time would increase direct cost prespecified project deadline time increase project duration occur prespecified direct cost
ability control engineering process execution vital importance success engineering project thus many studies focusing capitalizing knowledge practices systems engineering processes proposed former work complete solution syspem system process engineering metamodel problem starting engineering process models process orchestration execution control one main components solution scheduling engine able reach balance time consumption respective interest resource implemented solution context real life case study noticed inability provide high quality schedules available resources severely reduced limitation due fact scheduling engine limited using available resources given input absolute constraint paper provide solution problem proposition additional resources cost optimization context work strongly linked former publications conveniently cited paper completion original solution shall see end paper shall considered context case study order review execution results
accessible summary known subject serious gaming support learning development use serious games skills development rehearsal management events replicated real life well established serious games used mental health services none forensic mental health care paper adds existing knowledge serious game may coproduced forensic mental health service users game developers acceptability therapeutic use serious gaming forensic mental health service users providers implications practice computer games may used practitioners therapeutic work forensic mental health service users mental health nurses use serious games creatively safely bridge gap service users receiving care controlled environments living independent community abstract introduction assessment users skills confidence safely respond risky community based situations underpins discharge planning serious games used skills development study trialled use forensic mental health services aim aim develop test acceptability usability innovative serious game support forensic mental health service users preparation discharge method prototype serious game developed service users researchers acceptability usability testing undertaken service providers interviewed acceptability serious gaming forensic mental health services result prototype game produced successfully trialled service users however service users providers identified work needed done develop test game greater complexity discussion acceptability usability using serious games support service users develop skills needed successful discharge demonstrated implications practice mental health practitioners may use gaming support practice work innovatively professions game developers create new ways working forensic mental health services
parkinson disease neurodegenerative disorder characterized motor nonmotor symptoms nonmotor symptoms include cognitive deficits impairment emotions recognition ability associated loss dopaminergic neurons substantia nigra alteration frontostriatal circuits review analyzed studies social cognition ability patients searched pubmed web science databases screening references included studied review articles additional citations initial articles met search criteria total patients compared health controls different tests assessed subcomponents social cognition theory mind decision making emotional face recognition studies cognitive function patients focused executive function patients showed impairment social cognition earliest stages disease ability seems significantly associated cognitive functions
background incontinence constitutes major health problem affecting millions people worldwide present study aims assess cure rates treating urinary fecal incontinence number people may remain dependent containment strategies methods medline embase psycinfo cochrane central register controlled trials central cinahl pedro searched january june supplementary searches included conference abstracts trials registers included studies patients years reported treatment cure success rates patients treated intervention recognized international guideline algorithms followup months published onwards title abstract screening full paper screening data extraction risk bias assessment performed independently two reviewers disagreements resolved discussion referral third reviewer necessary narrative summary included studies presented results evidence found surgical interventions stress showed median cure rate interquartile range iqr people urgency mostly treated using medications median cure rate antimuscarinics iqr pelvic floor muscle training bulking agents showed lower cure rates sacral neuromodulation median cure rate iqr conclusions many individuals cured hence may continue rely containment studies found assessing success containment strategies lack data disabled neurological diseases elderly cognitive impairment surgical interventions effective stress interventions showed lower cure rates many individuals likely reliant containment strategies
advances information technology witnessed great progress healthcare technologies various domains nowadays however new technologies also made healthcare data much bigger also much difficult handle process moreover data created variety devices within short time span characteristics data stored different formats created quickly large extent regarded big data problem provide convenient service environment healthcare paper proposes cyber physical system patient centric healthcare applications services called health cps built cloud big data analytics technologies system consists data collection layer unified standard data management layer distributed storage parallel computing data oriented service layer results study show technologies cloud big data used enhance performance healthcare system humans enjoy various smart healthcare applications services
paper presents new driving method sulfur plasma lamp low power applications newly developed magnetron power supply mps series resonance type full bridge topology controlled phase shift track beam current magnetron drive sulfur plasma lamp optimally mps provide peak power discharge condition excite sulfur plasma lamp allow average power control light dimmer satisfying condition newly developed driving method uses burst mode enables peak average power controls satisfy conditions furthermore magnetizing current offset balancer developed guarantees zero voltage switching field effect transistors although mps operates burst mode thus proposed method provides easy lighting relighting optimized conditions high efficiency power mps delivered proposed method reached variable average power similar adjusting burst time proportionally experimental results proved feasibility proposed driving method
discourse managerial expertise favours rational analysis masculine ideals contemporary management literature also recognises value well employee voice workplace drawing upon narrative analysis interview data share unique insights lived experiences laura one female project manager recently managed construction site midlands contrast previous research indicates female managers tend conform quite traditional set gender behaviours laura embraces range workplace appropriate gendered strategies hard work horseplay together sensitivity caring draws mix gendered strategies negotiating two different discourses construction one professional one tough practical behaviour reproduces masculine ideals horseplay heroic management opens possibilities modernizing construction management caring combination strategies heart tacit expertise laura theoretically discussion adds development nuanced understanding management expertise situated person specific knowledge draws explicit tacit specifically centrality gendered strategies beyond masculine ideals success site highlighted
receptor tyrosine kinase like orphan receptor ror proteins conserved family tyrosine kinase receptors function developmental processes including cell survival differentiation cell migration cell communication cell polarity proliferation metabolism angiogenesis ror recently shown expressed various types cancer cells normal cells pharmacokinetics pharmacodynamics single chain fragment variable scfv antibodies provide potential therapeutic advantages whole antibody molecules present study scfvs specific peptide extracellular domain ror selected using phage display technology selected scfvs characterized using polyclonal monoclonal phage enzyme linked immunosorbent assay elisa soluble monoclonal elisa colony pcr sequencing antiproliferative apoptotic effects selected scfv antibodies also evaluated lymphoma myeloma cancer cell lines using mtt annexin assays results elisa indicated specific reactions isolated scfvs ror peptide colony pcr confirmed presence full length kappa inserts percentages cell growth treatment cells individual scfv revealed scfv significantly inhibited growth rpmi chronic lymphocytic leukemia cll cells comparison untreated cells interestingly treatment specific scfv induced apoptosis cell death rpmi cll cells taken together results demonstrate targeting ror using peptide specific scfv effective immunotherapy strategy hematological malignancies
paper focuses security assessment electricity distribution networks dns vulnerable distributed energy resource der nodes adversary model simultaneous compromise der nodes strategic manipulation generation setpoints loss defender operator includes loss voltage regulation cost induced load control supply demand mismatch caused attack three stage defender attacker defender dad game formulated stage defender chooses security strategy secure subset der nodes stage attacker compromises set vulnerable ders injects false generation setpoints stage defender responds controlling loads non compromised ders solving trilevel optimization problem hard due nonlinear power flows mixed integer decision variables address challenge problem approximated tractable formulation based epsilon linear power flow model set critical der nodes setpoint manipulations characterizing optimal attack strategy computed iterative greedy approach computing attacker defender strategies original nonlinear problem proposed results provide guidelines optimal security investment defender response preattack postattack conditions respectively
remotely piloted aircraft rpa used study collect high resolution data flow complex terrain potential site wind energy test field southern germany described system used retrieve information flow field turbulence intensity vertical wind components shear escarpment site known high wind potential measurements done aircraft several days varying wind weather conditions focus study characterisation flow field main wind direction neutral stratification shown flow inclination found escarpment attenuates within hundred metres downstream formation reattached boundary layer could measured well increased turbulence intensity reattachment zone results highly valuable information planning wind energy test site location experiment also used validation numerical simulations remote sensing instruments elsevier ltd rights reserved
susan albrecht career spanned years years served english teacher school psychologist behavior consultant coordinator services special education faulty member contributions field include leadership positions council children behavioral disorders susan shared reflections career view challenges facing field future
objective study aimed investigate whether negative impact result psoriatic arthritis disease inner ear function methods twenty four successive patients healthy volunteers younger years age followed least one year outpatient clinics physical therapy rehabilitation diagnosis psa according caspar criteria complain hearing impairment included study distortion product otoacoustic emission dpoae values khz khz tympanometric examination results stapes reflex values speech reception threshold srt speech discrimination values pure tone values high frequency values analyzed statistical comparisons groups performed using chi square test mann whitney test accepted level statistical significance results study population consisted male female patients mean age range years male female healthy volunteers mean age range years control group mean duration arthritis years evaluation hearing frequencies patients statistically significant difference found relative control group dpoae values patients analyzed within interval compared control group statistically significant difference found conclusion study provides strong evidence suggesting necessity monitorization patients regarding sensorineural hearing loss take measures development hearing loss early stage may another disability patients psa potential cause severe disability elsevier ireland ltd rights reserved
background aimslittle known aetiology morbidity clinical characteristics pyogenic liver abscess caused extended spectrum beta lactamase producing enterobacteriaceae methodsan analysis pyogenic liver abscess patients caused extended spectrum beta lactamase producing enterobacteriaceae isolates caused non extended spectrum beta lactamase producing enterobacteriaceae performed resultsamong pyogenic liver abscess patients patients pyogenic liver abscess biliary origin pyogenic liver abscess patients caused extended spectrum beta lactamase producing enterobacteriaceae isolates mainly escherichia coli klebsiella pneumoniae pyogenic liver abscess patients related biliary disorders pyogenic liver abscess patients caused extended spectrum beta lactamase producing enterobacteriaceae within pyogenic liver abscess patients caused enterobacteriaceae expressing extended spectrum beta lactamases occurrences pyogenic liver abscess patients associated biliary disorders compared pyogenic liver abscess patients caused non extended spectrum beta lactamase producing enterobacteriaceae significantly greater incidences polymicrobial infections bacteremia pulmonary infection recurrence death pyogenic liver abscess patients caused extended spectrum beta lactamase producing enterobacteriaceae carbapenems remain mainstay drugs extended spectrum beta lactamase producing coli pneumoniae independent risk factors occurrence pyogenic liver abscess caused extended spectrum beta lactamase producing enterobacteriaceae biliary disorders including extra intrahepatic cholangiolithiasis abnormal bilioenteric communication bile gut treatment history malignancy operation chemotherapy pulmonary infection diabetes mellitus conclusionspyogenic liver abscess caused extended spectrum beta lactamase producing enterobacteriaceae isolates mainly occurs patients biliary disorders treatment history malignancy mainstay treatment remains carbapenems combination adequate aspiration drainage
accumulating evidence suggests long noncoding rnas incrnas crucial regulators epithelial mesenchymal transition emt tgf beta signaling major inducer emt facilitate lung cancer metastasis however role lncrnas process remains largely unknown identified incrnas differentially expressed lung cancer tissues compared adjacent normal tissues gene body vicinity transcripts also bound smad expression linc significantly decreased cells treated tgf beta furthermore linc stably regulated lung cancer tissues compared normal tissues tcga data sets another published lung cancer data sets bioinformatics analysis suggested linc associated tgf beta might participate emt process moreover knocking linc promoted cell migration invasion whereas linc overexpression prevented cell metastasis importantly linc expression regulated smad linc affected several emt markers expression findings suggest linc mediator tgf beta signaling play significant role regulation emt lung cancer cell migration invasion elsevier rights reserved
design procedures currently applied dimensioning structural load bearing components conveyances specify safe service life instead based safety factors related static loads order solve problem work verified relationships find fatigue endurance structural elements conveyances function service time type conveyance required values applied loads considered function time normal operating conditions study compiling results research work undertaken department strength materials structures agh ust provides analytical formulas verified experimentally real objects yielding maximal loads experienced conveyance suspensions hoisting ropes start fully loaded conveyance moving bottom station maximal loads experienced conveyance suspensions hoisting ropes braking fully loaded conveyance approaching top station loads guiding system skip head shalt steelwork skip lower frame shaft steelwork skip travel fixed speed
mass spectrometry based proteomics achieved near complete proteome coverage humans several organisms producing wealth information stored databases bioinformatics resources recent implementation selected multiple reaction monitoring srm mrm technology targeted proteomics introduced possibility quantitatively follow specific protein targets hypothesis driven experiment contrast immunoaffinity based workflows typically used biological clinical research protein quantification srm mrm characterized high selectivity large capacity multiplexing approx proteins per analysis rapid cost effective transition assay development deployment concept srm mrm utilizes triple quadrupole qqq mass analyzer provide inherent reproducibility unparalleled sensitivity selectivity efficiently differentiate isoforms post translational modifications mutated forms proteins srmlike targeted acquisitions parallel reaction monitoring prm pioneered high resolution accurate mass platforms based quadrupole orbitrap orbitrap mass spectrometer expansion also caused development data independent acquisition dia review presents step step tutorial development srm mrm protein assay intended researchers without prior experience proteomics discus practical aspects srm based quantitative proteomics workflow summarize milestones basic biological medical research well recent trends emerging techniques elsevier rights reserved
twenty two novel substituted matrinic ethanol derivatives synthesized evaluated antiviral activities hcv taking compound lead sar study indicated shortening butyl chain ethyl chain affect activity significantly target compounds matrinic ethanol demonstrated potential anti hcv effect value value free hydroxyl arm made possible parent structure prepare pro drug potential application hcv treatment study provided powerful information strategic optimization development kind compounds novel family anti hcv agents elsevier ltd rights reserved
objective although growing body evidence suggests culture change corollary personcentered care improves resident outcomes nursing home setting little known effect culture change postacute setting patients receive skilled nursing rehabilitation services relatively short period time returning home design data study collected part larger project understand impact veterans health administration vha policies shift mission vha community living centers clcs long stay custodial care short stay skilled nursing rehabilitative care results although qualitative data collected interviews site visits eight geographically diverse clcs suggest increase quality life care veterans interview data also indicate unintended consequence specifically staff described aspects homelike environment relationship based care delivery attention veterans preferences characterize culture change prolong veteran length stay beyond treatment completion addition providing skilled nursing rehabilitation vha clcs also serve latent function providing comfortable home peer community veterans connect socialize one another congregate living environment persons shared symbolic status veteran unique vha clcs strong bonding among peers staff well staff respect veterans service country may increase sense obligation keep veterans past expected discharge date conclusion findings suggest complexities culture change veteran centered care short term care setting may underrecognized discuss findings may also relevant non vha sector amda society post acute long term care medicine
background child sexual assault csa global health problem affects many children often reported developing countries data csa countries aims objectives study aimed review pattern medical care victims csa tertiary hospital month period methods retrospective descriptive study case files cases csa retrieved patients seen paediatric patient department ekiti state university teaching hospital january march results victims csa accounted new patients seen period review yearly increase time victims female median age years age range genito urinary findings anal tear assailants male mostly adults school teacher school friends perpetrators cases respectively screened hiv screened hepatitis received hiv post exposure prophylaxis none given prophylaxis viral hepatitis eligible post exposure emergency contraception received antibiotics analgesics routinely given cases one patients attended follow none repeat serological screening tests police involved cases prosecution conclusion perpetrators csa protean study area gross inadequacies care provided victims standard treatment protocols additional training health care providers involved management csa victims required
several newly synthesized triazoles including aeuro nitrobenzyl methenylideneamino mercapto triazol methenyl triazole nmtt aeuro methoxybenzyl methenylideneamino mercapto triazol methenyl triazole mmtt aeuro chlorobenzyl methenylideneamino mercapto triazol methenyl triazole cmtt studied corrosion inhibitors mild steel hcl weight loss measurements electrochemical experiments quantum chemical calculations experimental results show compounds high inhibition efficiency order cmtt mmtt nmtt cmtt concentration showed highest inhibition efficiency adsorption inhibitors metal surface obeyed langmuir isotherm basic adsorption mechanism proposed based quantum chemical calculations
objectives evaluate relationship hemoglobin hbac risk left atrial thrombus spontaneous echo contrast lat sec non valvular atrial fibrillation patients methods retrospective study consecutive non valvular patients undergoing transesophageal echo cardiography prior radiofrequency catheter ablation electric cardioversion enrolled baseline characteristics collected analyzed results patients lat sec hbac levels patients lat sec significantly higher patients without lat sec mol independent risk factor lat sec odds ratio confidence interval conclusions elevated hbac indicated significantly increased risk lat sec non valvular patients hbac might significance predicting risk prothrombotic state non valvular
animals undergo remarkable transition active normal life dormant state called aestivation entry hypometabolic state ensures life continues even long periods environmental hardship study aimed identify central nervous system cns peptides may regulate metabolic suppression leading aestivation land snails mass spectral based neuropeptidome analysis cns comparing active aestivating states revealed differentially produced peptides upregulated active animals upregulated aestivated animals buccalin neuropeptide investigated since existing evidence molluscs buccalin modulates physiology muscle contraction theba pisana cns contains two buccalin transcripts encode precursor proteins capable releasing numerous buccalin peptides tpi buccalin highly expressed within cns transcriptome derived multiple metabolic states significant difference observed level gene expression levels tpi buccalin active aestivated animals suggesting regulation may reside level post translational control peptide abundance spatial gene peptide expression analysis aestivated snail cns demonstrated buccalin widespread distribution within regions control several physiological roles conclusion provide first detailed molecular analysis peptides associated genes related hypometabolism gastropod snail known undergo extended periods aestivation elsevier inc rights reserved
novel series vicinal diaryl azole urea derivatives synthesized evaluated potential inhibit soat enzyme among reported compounds compound emerged potent compound value polaxamer induced lipoprotein lipase inhibition model compound reduced triglyceride turnover vivo compound also showed dose dependent prevention serum total cholesterol prevention ldl elevation dose furthermore compound showed potential stop falling levels serum hdl dose dependently improved atherogenic index effect body weight plaque formation development atherogenic lesions studied toxicological study compound indicated dose devoid signs toxicity mortality elsevier masson sas rights reserved
pathogen fusarium graminearum producer mycotoxin deoxynivalenol sitobion avenae aphids reside onwheat ears explored influence earlier aphid infestation expression profile specific molecular markers associated graminearum infection using reverse transcription quantitative polymerase chain reaction analysis followed expression wheat defence genes avenae infestation explored effect subsequent graminearum infection performed assessment disease symptoms fungal biomass mycotoxin production number aphids several time points disease progress wheat ears infected graminearum showed disease symptoms higher deoxynivalenol levels ears pre exposed aphids relative sole inoculation graminearum aphids induced defence genes typically induced graminearum infection defence genes showed earlier enhanced transcription exposure aphids graminearum discussion link symptomatic epidemiological parameters transcriptional induction pattern plant study suggests pre exposure wheat ears aphids affects plant response plays role subsequent attack graminearum enabling fungus colonize wheat ears rapidly
study investigated application geotextiles sustainable urban drainage systems degradation organic pollutant load present stormwater three experimental granular filter rigs used packed alternating layers made gravel pea gravel sand either upper layer upper lower layer layer geotextile hydraulic loading capacity matched commonly used conventional sand filters standard water quality parameters measured collated data evaluated using anova levine test homogeneity variance procedure found rig upper lower geotextiles statistically significant difference data rig single geotextile layer high chemical oxygen demand suspended solids removal rates occurred rigs however control rig showed increased outflow concentration nutrients indicating potential geotextiles stormwater treatment
men ages years develop complaints symptoms reminiscent menopausal complaints women parallels sought changes female male endocrinology period life indeed men show decline serum testosterone age years onwards slow decline per year time may amount hypogonadism mechanism decline serum testosterone men resemble menopause partially aging neuroendocrine system less efficient testosterone production equally important result inhibition testosterone production metabolic factors relation visceral obesity effects part reversible weight loss hypogonadal state aging men deleterious effects mortality causes highest men low testosterone impacting metabolic state leading diabetes mellitus cardiovascular disease osteoporosis sexual dysfunction normalization testosterone aging hypogonadal men beneficial effect pathologies fear testosterone treatment elderly men would lead prostate disease substantiated studies men menopause testosterone deficiency old age deserves serious attention elsevier ireland ltd rights reserved
aims identify distinct classes smokers based quit day withdrawal symptoms explore relations withdrawal classes demographics tobacco dependence treatment smoking outcomes design secondary data analysis participants randomized double blind placebo controlled multi site smoking cessation trial provided ecological momentary assessments withdrawal symptoms quit day participants received smoking cessation counseling randomized receive placebo one five active pharmacotherapies setting research offices madison milwaukee wisconsin usa participants adult smokers female white recruited community via advertisements abstained quit day measurements demographics tobacco dependence assessed baseline participants carried palmtop computers record withdrawal symptoms craving negative affect difficulty concentrating hunger anhedonia quit day point prevalence abstinence latency relapse assessed weeks months post quit findings latent class analysis identified four withdrawal classes akaike information criterion aic moderate withdrawal sample high craving anhedonia sample affective withdrawal sample hunger sample high craving anhedonia class reported significantly higher dependence less likely received combination nicotine replacement reported lower week abstinence rates relapsed sooner moderate withdrawal class affective withdrawal class reported higher levels baseline negative affect life time psychopathology relapsed quickly moderate withdrawal class conclusions majority smokers report typical levels withdrawal symptoms quit day one third report extreme craving extreme negative affective extreme hunger responses initial abstinence distinct quit day withdrawal symptom patterns related baseline characteristics treatment cessation success
background blunted facial affect common negative symptom schizophrenia additionally assessing trustworthiness faces social cognitive ability impaired schizophrenia currently available pharmacological agents ineffective improving either symptoms despite clinical significance hypothalamic neuropeptide oxytocin multiple prosocial effects administered intranasally healthy individuals shows promise decreasing negative symptoms enhancing social cognition schizophrenia although two small studies investigated oxytocin effects ratings facial trustworthiness schizophrenia effects facial expressivity investigated population method investigated effects oxytocin facial emotional expressivity participants performed facial trustworthiness rating task individuals schizophrenia age matched healthy controls using double blind placebo controlled cross design participants rated trustworthiness presented faces interspersed emotionally evocative photographs video recorded participants facial expressivity videos quantified blind raters using well validated manualized approach facial expression coding system faces results oxytocin administration affect ratings facial trustworthiness significantly increased facial expressivity individuals schizophrenia trend level healthy controls conclusions results demonstrate oxytocin administration increase facial expressivity response emotional stimuli suggest oxytocin may potential serve treatment blunted facial affect schizophrenia
objective providing patient centered care requires consideration numerous factors making decisions influence patient health status background clinical decisions informed relevant research evidence literature often lacks pertinent information problems encountered routine clinical practice although randomized clinical trial provides best research design ensure internal validity study findings ethical considerations competitive culture sport often preclude random assignment patients participants control condition clinical advantages cohort study design bayesian approach data analysis provide valuable evidence support clinical decisions dichotomous classification outcome predictive factors permits quantification likelihood occurrence specified outcome conclusions multifactorial prediction models reduce uncertainty clinical decision making facilitate individualization treatment thereby supporting delivery clinical services evidence based patient centered
wheel torque control bandwidth vehicle dynamics model crucial evaluating optimal tracking ability tire slip analysis control system stability electric drives control dynamics influenced timing digital control events sampling instant motor currents reflecting timing drive analytical models therefore important analysis vehicle traction systems paper considers five various transfer function models including issues digital control events timing aim paper compare accuracy models representing dynamics permanent magnet synchronous motor pmsm drive bode characteristics analytical models compared reference model comparison made three commonly used cases pmsm current sampling applicability presented models discussed frameworks use specific models indicated
rapid development electrical circuits micro electromechanical system mems network technology wireless smart sensor networks wssn shown significant potential replacing existing wired shm systems due cost effectiveness versatility structural systems monitored using wssn measuring acceleration temperature wind speed humidity however multi scale sensing device capability measure displacement yet developed previous paper new high accuracy displacement sensing system developed combining high resolution analog displacement sensor mems based wireless microprocessor platform also wireless sensor calibrated laboratory get high precision displacement data analog sensor performance validated measure simulated thermal expansion laboratory bridge structure paper expands validation developed system full scale experiments measure static dynamic displacement expansion joints temperature vibration service highway bridge brief visual investigation bridges comparison theoretical measured thermal expansion also provided developed system showed capability measure displacement accuracy
memory researchers long speculated certain tactics may lead people recall crimes never occurred thus could potentially lead false confessions first study provide evidence suggesting full episodic false memories committing crime generated controlled experimental setting suggestive memory retrieval techniques participants induced generate criminal noncriminal emotional false memories compared false memories true memories emotional events three interviews participants classified false memories committing crime theft assault assault weapon led police contact early adolescence volunteered detailed false account reported false memories crime similar false memories noncriminal events true memory accounts kinds complex descriptive multisensory components appears context highly suggestive interview people quite readily generate rich false memories committing crime
computational thermodynamics known calphad method dawned aimed coupling phase diagrams thermochemistry computational techniques eventually evolves toward kinetic simulations integrated thermodynamic calculations computational kinetics including diffusion controlled phase transformation precipitation simulation phase field simulation meantime thermodynamic mobility physical property databases multi component multi phase materials served basic knowledge materials design critically evaluated calphad approach combining key experiments first principles calculations statistic methods empirical theories combination computational techniques conjugated databases makes possible simulate phase transformations predict microstructure evolution real materials foreseeable future links microand macro scale simulations lead multi scale computational framework aid search quantitative relations among chemistry process microstructures materials properties order accelerate materials development deployment new route materials process design pursued integrated computational materials engineering icme materials genome initiative mgi article presents review basic theories applications state art perspective computational thermodynamics kinetics
business process reengineering one main problems consists organizational reintegration employee new instruments automatic identification stakeholders among existing staff evaluation needed difficult identify stakeholder especially refer science stakeholders proper evaluation researcher value position international level needed large contradictions concerning validity various types indexing services techniques used classify researchers paper proposes use corporate human resource management hrm specific instruments comes researcher informational stakeholder identification main idea behind method use form information retrieval techniques set research papers contain mostly key words extract hierarchy researchers involved referenced set distributed approach used due inherent scalability use inference engine also deemed necessary due complexity problem system may used automatic assessment research performance public private institutions easily modified support complex sets rules depending user needs personnel evaluation main research field papers concerns distributed artificial intelligence elsevier ltd rights reserved
hierarchical data found variety database applications including content management categories forums business organization charts product categories paper examine two models deal hierarchical data relational databases namely adjacency list model nested set model analysed models executing various operations queries web application management categories thus highlighting results obtained performance comparison tests purpose paper present advantages disadvantages using adjacency list model compared nested set model relational database integrated application management categories needs manipulate big amount hierarchical data
tree shadowing significant mobile satellite radio propagation investigation must known successful link design therefore limited data relevant problem purpose propagation measurements uhf band performed trabzon turkey respectively experiments executed transmitter top high building receiver system located van outfitted antenna roof receiver equipment interior measurements carried different tree types results bands presented tabular graphical forms experiments repeated trees months april september variations tree attenuation examined months without foliage average values tree attenuations found uhf band respectively scaling factor uhf band attenuations decibels determined approximately using measured parameters fade depth statistics calculated using lognormal shadowing model establish validity obtained results design mobile satellite links results compared previous investigations
migraine disabling brain disorder involving abnormal trigeminovascular activation sensitization fasting skipping meals considered migraine trigger altered fasting glucose insulin levels observed migraineurs therefore peptides involved appetite glucose regulation including insulin glucagon leptin could potentially influence migraine neurobiology aimed determine effect insulin glucagon leptin signaling trigeminovascular nociceptive processing level trigeminocervical complex hypothalamus male rats anesthetized prepared craniovascular stimulation vivo electrophysiology used determine changes trigeminocervical neuronal responses dural electrical stimulation phosphorylated extracellular signal regulated kinases perk immunohistochemistry determine trigeminocervical hypothalamic neural activity response intravenous administration insulin glucagon leptin vehicle control combination blood glucose analysis blood glucose levels significantly decreased insulin leptin whereas glucagon opposite effect dural evoked neuronal firing trigeminocervical complex significantly inhibited insulin glucagon leptin trigeminocervical complex perk cell expression significantly decreased insulin leptin increased glucagon compared vehicle control however leptin affected perk expression hypothalamus significantly decreasing perk immunoreactive cell expression arcuate nucleus findings demonstrate insulin glucagon leptin alter transmission trigeminal nociceptive inputs potential neurobiological link migraine impaired metabolic homeostasis may occur disturbed glucose regulation transient hypothalamic dysfunction author published elsevier inc open access article license
paper presents design innovative device applies dynamic mechanical load human knee joints dynamic loading employed applying cyclic periodic force target area repeated force loading considered effective modality repair rehabilitation long bones subject ailments like fractures osteoporosis osteoarthritis etc proposed device design builds knowledge gained previous animal mechanical studies employs modified slider crank linkage mechanism actuated brushless direct current motor provides uniform cyclic force functionality device simulated software environment structural integrity analyzed using finite element method prototype construction device controlled microcontroller programmed provide desired loading force predetermined frequency specific duration device successfully tested various experiments usability full functionality results reveal device works according requirements force magnitude operational frequency device considered ready used clinical study examine whether controlled knee loading could effective regimen treating stated bone related ailments
integration renewable energy sources increases complexity maintaining power grid particular highly dynamic nature generation consumption demands better utilization energy resources seen cost storage infrastructure achieved demand response accordingly availability energy potential overload situations reflected using price signal effectiveness mechanism arises flexibility device operation nevertheless heavily reliant exchange information grid consumers paper investigate capability interactive energy management system timely inform users energy usage order promote optimal use local resources particular analyze data collected several households italy austria gain insights usage behavior drive design effective systems outcome formulation energy efficiency policies residential buildings well design energy management system consisting hardware measurement units management software mjolnir framework release open use provides platform various feedback concepts implemented assessed includes widgets displaying disaggregated aggregated consumption information well daily production tailored advices formulated policies implemented advisor widget able autonomously analyze usage provide tailored energy feedback advisor estimated leading potential savings using measurement data greend dataset
growing concern human factors green building imperative high rise high density urban environments paper describes attempts explore influence workplace green features green certification ventilation mode building morphology health perceptions personal sensation sensorial assumptions healing performance based survey hong kong singapore results validated relationship green features health perceptions workplace environment remarkably participants air conditioned offices revealed significant higher concerns health issues participants mixed ventilated offices mixed ventilation design performs bridge connect indoor environment outdoor space enables people contact nature additionally preferred building morphology workplace pattern building complex instead single building complex form integrates configuration courtyards podium gardens green terrace public plaza types open spaces building clusters contributes better health perceptions research contributes rationalization optimization passive climate adaptive design strategies green buildings high density tropical subtropical cities
human memory often inaccurate similar words figures new faces often recognized seen studied items long short term memory tests however neural mechanisms underlying false memory remain elusive previous fmri study using morphed faces standard false memory paradigm found shaped response curve amygdala old new lure items indicates amygdala active response items salient hit correct rejection compared items less salient false alarm terms memory retrieval present fmri study determined whether false memory faces occurs within short term memory range seconds assessed neural correlates involved veridical illusory memories nineteen healthy participants scanned mri short term memory task using morphed faces behavioral results indicated occurrence false memories within short term range found amygdala displayed shaped response curve memory items similar observed previous study results suggest amygdala plays common role long short term false memory faces made following conclusions first amygdala involved detecting saliency items addition fear supports goal oriented behavior modulating memory second amygdala activity response time might related subject response criterion similar faces elsevier rights reserved
mass customisation model discussed competitive positioning strategy marketplace adding value customer end use includes user part construction process responding customer demands wishes present day almost proposals mass customisation focused design phase single family houses reality processes carried work execution inefficient costs mass customisation models assumed customer offer solutions support change management furthermore inefficiency often makes mass customisation unfeasible terms deadlines site management therefore present proposal focuses achieving paradigm mass customisation traditional residential construction complementary existing proposals design phase proposal framework integral management work execution address change management introduced users offering efficient productive model reduces costs process model focus synergy different strategies techniques technologies currently used construction management lean construction six sigma together strategies technologies proven valid solutions fields business process management service oriented architecture etc
present study aimed analyze imaging clinical pathological features fungal infection involvement primary biliary cirrhosis pbc retrospectively analyzing reviewing features two patients fungal infection involvement pbc patients female one patient confirmed diagnosis pbc patient confirmed sjogren syndrome pbc two cases pbc infected fungal infection treatment hormonal immunosuppressive agents rcr sputum confirmed pneumocystis spp infection patient pbc alone mucormycosis infection confirmed patient pathological examination renal biopsy state illnesses progressed quickly patients ultimately succumbed conditions patient prognosis fungal infection involvement pbc poor patients treated long term hormone immunosuppressive agents monitored
background radioiodine effective treatment hyperthyroidism cats optimal dose restore euthyroidism without inducing hypothyroidism unclear treatment induced hypothyroidism lead azotemia reduced duration survival objective compare efficacy short term outcomes low dose versus higher standard dose treatment hyperthyroidism animals total client owned cats undergoing treatment mild moderate hyperthyroidism serum methods prospective nonrandomized cohort study comparing treatment either low dose mci standard dose mci serum thyroid stimulating hormone tsh creatinine concentrations measured months determine persistent hyperthyroidism overt hypothyroidism low high tsh subclinical hypothyroidism normal high tsh azotemia results significant difference prevalence cats persistent hyperthyroidism standard low dose treatment groups versus versus months overt versus subclinical versus hypothyroidism common cats months standarddose difference incidence azotemia existed groups cats treated standard dose higher creatinine concentrations higher percent rises creatinine reduced frequency iatrogenic hypothyroidism azotemia
accurate combustion parameters foundations effective closed loop control engine combustion process combustion parameters including start combustion location peak pressure maximum pressure rise rate location identified engine block vibration signals signals often include non combustion related contributions limit prompt acquisition combustion parameters computationally main component non combustion related contributions considered caused reciprocating inertia force excitation rife engine crank train mathematical model established describe response rife parameters model recognized pattern recognition algorithm response rife predicted related contributions removed measured vibration velocity signals combustion parameters extracted feature points renovated vibration velocity signals angle deviations feature points vibration velocity signals cylinder pressure signals start combustion system bias adopted correct deviation error bound predicted parameters within degrees predict location maximum pressure rise rate location peak pressure algorithms based proportion high frequency components vibration velocity signals introduced tests results show two parameters able predicted within degrees degrees error bound respectively increase knee point preceding peak value point peak value vibration velocity signals used predict value maximum pressure rise rate finally monitoring frame work inferred realize combustion parameters prediction satisfactory prediction combustion parameters successive cycles achieved validates proposed methods elsevier ltd rights reserved
lipid transporter atp binding cassette class abca plays critical role biogenesis alveolar type cell lamellar bodies lbs relatively large number mutations abca gene identified association diffuse parenchymal lung disease dpld common missense mutation valine substitution lysine residue abca leads functional impairment transporter vitro consequences abca gene expression vivo unknown address question developed mouse models expressing abca knocked endogenous mouse locus parental mouse line mabca retained intronic pgk neo selection cassette inserted reverse orientation mabca rneo demonstrated allele dependent extracellular surfactant phospholipid deficiency hypothesize deficiency leads aberrant parenchymal remodeling contributing pathophysiology dpld phenotype compared wild type littermates baseline studies mice homozygous pgk neo insert mabca rneo revealed nearly reduction bronchoalveolar lavage bal content accompanied quantitative reduction size compensatory increase number phenotypic alteration surfactant lipid homeostasis resulted early macrophage predominant alveolitis peaked weeks age followed age dependent development histological dpld characterized initially peribronchial inflammatory cell infiltration culminating emphysema like phenotype included stereologically quantifiable reductions alveolar septa surface area volume septal wall tissue plus foci trichrome positive collagen deposition together substantial proliferation hyperplastic cells addition spontaneous lung remodeling mabca rneo mice rendered vulnerable exogenous injury three weeks following intratracheal bleomycin challenge mabca rneo mice demonstrated allele dependent susceptibility bleomycin including enhanced weight loss augmented airspace destruction increased fibrosis removal rneo cassette mabca alleles resulted restoration bal content wild type levels absence changes lung histology weeks age results support importance surfactant homeostasis susceptibility factor intrinsic exogenously induced lung injury remodeling elsevier gmbh rights reserved
multiscale multi physics applications central solve increasing number important scientific challenges computationally speaking difficulty combine high performance computing need couple various codes solvers representing different scale different physical process paper present muscle hpc new hpc implementation muscle previously developed multiscale coupling library environment present design implementation demonstrate advantages compared muscle conduct performance comparison tightly coupled mpi application use case results indicate using muscle hpc couple submodels within hpc cluster lead better computing performance comparable native mpi execution thus reduce coupling overhead elsevier rights reserved
real time structural parameter identification damage detection great significance structural health monitoring systems extended kalman filter implemented many structural damage detection methods due capability estimate structural parameters based online measurement data current research assumes constant structural parameters uses static statistical process control damage detection however structural parameters typically slow changing due variations environmental operational effects hence false alarms may easily triggered data points falling outside static statistical process control range due environmental operational effects order overcome problem article presents novel real time structural damage detection method integrating extended kalman filter dynamic statistical process control based historical measurements damage sensitive parameters state space model extended kalman filter used provide real time estimations parameters well standard derivations time step used update control limits dynamic statistical process control detect abnormality selected parameters numerical validation performed linear nonlinear structures considering different damage scenarios simulation results demonstrate high detection accuracy rate light computational costs developed extended kalman filter dynamic statistical process control damage detection method potential implementation structural health monitoring systems service civil structures
two purposes study select data mining model predict learners academic performance computer programming subject group learners cooperative learning comparing efficiency models created data mining classification technique develop model cooperative learning via web using selected data mining model group learners efficiency seven models created data mining classification technique using seven algorithms artificial neural network nearest neighbor naive bayes bayesian belief network jrip compared found models created best efficiency accuracy model created accuracy tests show model reliable therefore model selected group learners stad technique cooperative learning web result also shows inappropriate predict learners performance data mining model created shows math gpa influential academic performance computer programming subject model cooperative learning model via web using group learners consists components data management module prediction grouping module learning resources cooperative community quiz module results also show case using selected model group learners case grouping learners lecturers learning progressive score first case higher
wine particularly red wine beverage great chemical complexity continuous evolution chemically wine hydroalcoholic solution similar water comprises wide variety chemical components including aldehydes esters ketones lipids minerals organic acids phenolics soluble proteins sugars vitamins flavonoids constitute major group polyphenolic compounds directly associated organoleptic health promoting properties red wine however due insufficient epidemiological vivo evidences subject presence high number variables human age metabolism presence alcohol complex wine chemistry wide array vivo biological effects compounds suggest cautious conclusions may drawn studies focusing direct effect wine specific health issue nevertheless several reports health protective properties wine phenolics several diseases cardiovascular diseases cancers obesity neurodegenerative diseases diabetes allergies osteoporosis different interactions wine flavonoids may key biological targets crucial health promoting effects interaction wine flavonoids specific enzymes one example way wine flavonoids may absorbed metabolized could interfere bioavailability therefore health promoting effect hence reports focused flavonoids absorption metabolism microbiota effect overall flavonoids bioavailability review summarizes major issues directly related potential health promoting effects wine flavonoids reports related flavonoids health highlight relevant scientific information however still gap knowledge wine flavonoids bioavailability health promoting effects vivo results well studies focused flavonoid metabolites still required moreover also necessary better understand biological interactions microbiota cells enzymes general biological systems could interfere flavonoid bioavailability
paper rtk gps system used movement data collection two identification models namely multi input single output miso robust fit regression neural network auto regression moving average exogenous input nnarmax models used identification data analysis test results indicate nnarmax models defined taking account results robust regression analysis estimate structural movements accurately nnarmax model robust fit regression models good capacities mapping relationship applied loads effects factors displacements tower however temperature humidity effects entire modal shapes insignificant traffic loads main factor affects tower bridge displacement elsevier ltd rights reserved
recently sparse representation based clustering attracted growing interests field image processing pattern recognition since technology favorable category distinguishing ability introduce fuzzy clustering paper propose new clustering algorithm called sparse learning based fuzzy means fcm firstly reduce computation complexity based fcm method energy discriminant feature obtained solving model reserved remainder discarded way redundant information correlation among samples different classes discriminant feature also removed improve clustering quality furthermore enhance clustering performance position information valid values discriminant feature also used define distance sample clustering center fcm weighted distance fcm enhance similarity samples class difference samples different classes thus improve clustering result addition dimension stored discriminant feature sample different use set operations formulate distance cluster center fcm comparisons several datasets images demonstrate fcm performs better state art methods higher accuracy keeps low spatial computational complexity especially large scale dataset image elsevier rights reserved
regulator tregs inflammation transcription factor forkhead winged helix transcription factor foxp plays important roles types dermatitis however detailed mechanism foxp well defined increasing evidence indicates foxp involves epigenetic mechanisms fulfill functions anticipated several types mechanisms might link foxp epigenetic profile assessed impact foxp global profile histone acetylation methylation found overexpression foxp increased histone lysine demethylation hkme hkme lysine acetylation hkac hkac cells exposed ultraviolet light foxp clearly increased levels hkac hkac hypoxia increased modifications whereas overexpression foxp hypoxia stabilized hkme hkme hkac hkac levels almost back normal foxp functions opposite traf tnf receptor associated factor modifications modifications altered foxp may influence cell cycle apoptosis showed foxp increased proportion cells phase decreased proportion cells phase markedly enhanced cell apoptosis conclusion work provides evidence foxp epigenetic regulator implies new molecular basis pathogenesis diseases
introduction limited evaluation clinical theoretical claims sexual thoughts children coercing others facilitate sexual offending nature thoughts contain also unknown aim examine relation child coercive sexual thoughts sexual offending determine nature thoughts differences among sexual offending non sexual offending nso non offending men methods cross sectional computerized survey anonymous qualitative quantitative self reported sexual thought experience data collected adult volunteers composing equal numbers nso men recruited medium security prison community sample men main outcome measures computerized interview sexual thoughts computerized inventory sexual experiences results three analytical approaches found child sexual thoughts related sexual offending sexual thoughts coercive themes latent class analyses identified three types child sexual thought primarily differentiated interpersonal context reporting emotions emotions others four types sexual thoughts coercing others chiefly discriminated person response emotional states reported consent non consent mixed type child sexual thought participant group significantly related type coercive sexual thought group marginally related consensual type common group non consensual type common group expected statistically conclusion child sexual thoughts risk factor sexual offending assessed clinicians general sexual thoughts coercive themes risk factor although thought type could important thoughts person expresses enduring lack consent exploring dynamic risk factors associated type child coercive thought could lead targeted treatment copyright international society sexual medicine published elsevier inc rights reserved
aimto identify potentially modifiable risk factors cognitive decline among veterans home residents taiwan methodsthe present retrospective cohort study part veteran affairs comprehensive geriatric assessment study retrieved data comprehensive geriatric assessment residents living four veterans homes taiwan study participants interviewed every months january december demographic characteristics multimorbidity charlson comorbidities index physical function barthel index cognition mini mental state examination mmse depression five item geriatric depression scale nutritional status mini nutrition assessment short form collected analysis generalized estimating equation model used adjusted age educational level five item geriatric depression scale problem communication difficulty identify potential modifiable risk factors cognitive decline resultsthe mean age participants years mean follow period weeks prevalence cognitive impairment defined mmse whereas study participants positive depressive symptoms approximately one fifth study participants using psychotropic agents higher among participants cognitive impairment without generalized estimating equation model physical function nutritional status depressive symptoms drinker multimorbidity stool incontinence positively correlated mmse score whereas advanced age low educational level years presence communication difficulty use psychotropic agents inversely associated mmse score conclusionsphysical function nutritional status positively associated mmse score use psychotropic agents negatively correlated cognitive function intervention study required improve cognitive health older adults living veterans retirement communities geriatr gerontol int suppl
paper focusing evaluating real technical losses within distribution network study conducted distribution system operator within romanian power system algorithm proposed authors able compute load dependent non dependent technical losses analyzed area represented real part romanian power system quantitative qualitative field measurements provided discussed followed technical losses computing based provided algorithm
multistage flash desalination msf currently facing enormous challenge cutting cost within last years msf experienced gradual decline investment compared techniques desalting water thus significant improvement required remain attractive capital investors improved process control cost effective approach energy conservation increased process profitability work dynamic model presented using gproms model builder optimize control msf process proportional integral derivative controller pid generic model control gmc used successfully control top brine temperature tbt brine level last stage different times year objectives study firstly obtain optimum tbt profiles four different seasons throughout year minimizing total seasonal operating cost tsoc secondly track optimum tbt profiles using pid gmc controllers without presence constraints thirdly examine types controllers handle disturbances occur plant results promising show gmc controller provides better performance conventional pid controller handle nonlinear system elsevier ltd rights reserved
topic article development open source automated design framework synthetic biology specifically design artificial gene regulatory networks based digital approach opposition tools geneda open source online software based existing tools used microelectronics proven efficiency last years complete framework composed computation core directly adapted electronic design automation tool input output interfaces library elementary parts achieved gene regulatory networks interface electrical circuit simulator modules extension microelectronics tools concepts odin abc verilog language spice simulator systemc ams geneda first validated benchmark several combinatorial circuits results highlight importance part library framework used design sequential circuit including biological state machine
onset timing growth children adolescents occurs considerable variability cohorts chronological age musculoskeletal system changes proportion time lever arm changes altered individual flexibility strength lead age specific injury patterns youth sports sports juniors commonly grouped according chronological age early late maturing children adolescents might therefore routinely trained relation biology represents risk overuse injury might limit development sports obtain information biological age children challenging numerous methods studied validated however implementation methods large scale still come report provides brief overview growth dynamics relation youth sports injuries describes challenges future
three hundred forty two university students completed short dark triad edinburgh handedness inventory ehi inconsistent handers showed higher psychopathy scores consistent handers handedness differences observed narcissism machiavellianism participants subdivided quartile low moderately low moderately high high psychopathy groups non clinical absolute ehi scores equally distributed among low moderate groups significantly lower high psychopathy group findings suggest inconsistent handedness associated upper quartile psychopathy scores also males showed significantly higher psychopathy scores females ratio male female inconsistent handers decreased psychopathy score increased genderxhandedness interaction indicated female male inconsistent handers higher psychopathy scores consistent handers although significant effects small participants range potential clinical diagnosis reader therefore strongly cautioned equating inconsistent handedness psychopathy
research performed investigate behavior geosynthetic reinforced sandy soil foundations study effect different parameters contributing performance using laboratory model tests parameters investigated study included top layer spacing number reinforcement layers vertical spacing layers tensile modulus type geosynthetic reinforcement embedment depth shape footing effect geosynthetic reinforcement vertical stress distribution sand strain distribution along reinforcement also investigated test results demonstrated potential benefit using geosynthetic reinforced sand foundations test results also showed reinforcement configuration layout significant effect behavior reinforced sand foundation two layers reinforcement settlement reduced footing pressure levels sand reinforced composite geogrid geotextile performed better reinforced geogrid geotextile alone inclusion reinforcement redistribute applied footing load uniform pattern hence reducing stress concentration result reduced settlement finally results model tests compared analytical solution developed authors previous studies analytical solution gave good predication experimental results footing geosynthetic reinforced sand japanese geotechnical society production hosting elsevier rights reserved
malnutrition childhood trauma shown affect opposite way cortisol awakening response car patients anorexia nervosa assess influence binge purging behaviour car patients measured car restrictive anr binge purging anbp patients without history childhood maltreatment seventeen anbp women anr women healthy women collected saliva samples awakening min filled eating disorder inventory edi anr anbp patients exhibited car significantly higher healthy women moreover car anbp women even higher anr women positively correlated bulimia subitem scores edi present findings show first time differences car anbp anr subtypes may suggest possible connection hpa axis functioning binge purging copyright john wiley sons ltd eating disorders association
petrochemical plants require addition removal energy process movement material within process piping vessels fundamental mass energy transfer requirements typically achieved use process utilities include electricity steam fuel gas cooling water compressed air utilities responsible significant portion operating cost plant therefore reduction consumption utilities common process optimisation area situation different comes generation transportation utilities often overlooked regard optimisation paper potential benefits utility optimisation illustrated particular focus generation transportation areas main objectives reductions electrical energy consumption cost illustrated dual circuit cooling water system system non linear also hybrid sense contains continuous discrete input variables significantly complicates design implementation control optimisation solutions paper illustrates cost energy consumption hybrid system reduced implementation hybrid non linear model predictive control hnmpc economic hnmpc ehnmpc results compared base case advanced regulatory control arc case showing significant additional benefit may achieved implementation advanced control optimisation techniques paper illustrates additional capital necessarily required implementation techniques elsevier ltd rights reserved
one popular fresh fruit banana musa acuminata cultivated world subtropical tropical areas recent years pathogen fusarium oxysporum cubense foc widely rapidly spread banana cultivated areas causing substantial yield loss however molecular mechanism banana response foc remains unclear functional identification disease related genes also limited study nine kda heat shock proteins hsps genomewide identified moreover expression profile different organs developmental stages response abiotic fungal pathogen foc systematically analyzed notably found transcripts mahsps commonly regulated melatonin acetyl methoxytryptamine foc infection studies showed exogenous application melatonin improved banana resistance fusarium wilt effect lost cotreated hsp inhibitor geldanamycin gda moreover melatonin gda opposite effect auxin level response foc melatonin gda cotreated plants significant effect suggesting involvement mahsps cross talk melatonin auxin response fungal infection taken together study demonstrated mahsps essential melatonin mediated plant response fusarium wilt extends understanding putative roles mahsps well melatonin biological control banana fusarium wilt
background autobiographical memory plays key role self understanding psychological health deficits autobiographical memory well established autism studies focused adolescence critical period developing self self esteem method adolescents autism spectrum disorder asd typically developing adolescent controls matched gender asked provide three self defining three everyday memories participants rated memories emotional intensity visual perspective extent self revealing memories independently rated self defining everyday experiences according valence theme self esteem depressed mood assessed self report questionnaires results group differences ability recognise self defining memories assessed independent reports groups also reported self defining memories intense everyday memories however adolescents asd contrast non asd controls reported self defining memories reveal less everyday memories relative controls retrieved fewer memories achievement theme memories recreational theme control group showed bias towards retrieving positive rather negative self defining memories asd group showed tendency self esteem mood poorer asd group self esteem related retrieval negative self defining memories conclusions adolescents asd exhibit instable self representation recognise types past experiences define feel weak connections memories elsevier ltd rights reserved
background next generation sequencing ngs technologies enable studies analyses diversity cell receptors tcr bcr human animal systems elucidate immune functions health disease last years several algorithms tools developed support respective analyses raw sequencing data immune repertoire tools focus distinct aspects data processing require strong bioinformatics background facilitate analysis cell repertoires less experienced users software needed combines common tools repertoire analysis results introduce graphical user interface gui providing complete analysis pipeline processing raw ngs data human animal tcr bcr clonotype determination advanced differential repertoire studies provides two applications clonocalc prepares raw data downstream analyses combines demultiplexer barcode splitting employs mixcr paired end read merging extraction human animal tcr bcr sequences clonoplot wraps package tcr contributes self developed plots descriptive comparative investigation immune repertoires conclusion workflow reduces amount programming required perform respective analyses supports communication training scientists technicians across scientific disciplines open source development java modular invites advanced users extend functionality software documentation freely available https bitbucket org clonosuite clonocalc plot
individual level characteristics including socioeconomic status associated poor metabolic cardiovascular health however residential area level characteristics may also independently contribute health status current study used hierarchical clustering aggregate census block groups durham orange wake counties usa six homogeneous clusters similar characteristics based demographic factors assigned cardiac catheterization patients clusters based residence first catheterization controlling individual age sex smoking status race elevated odds patients obese odds ratio confidence intervals diabetes congestive heart failure hypertension cluster urban impoverished unemployed compared cluster urban low percentage people impoverished unemployed findings demonstrate feasibility applying hierarchical clustering assessment area level characteristics living impoverished urban residential clusters may adverse impact health
paper deals cylinder flow field analysis two stroke engine motoring conditions particle image velocimetry piv computational fluid dynamics cfd main objective analyze effect engine parameters viz engine speed compression ratio port orientation cylinder flows loop scavenged two stroke gasoline direct injection gdi engine aim help researchers design fuel efficient less polluting two stroke engines study single cylinder two stroke engine commonly used two wheeler application considered engine cylinder modified provide optical access cylinder region piv experiments conducted various engine speeds viz rev min plane averaged velocity vector fields obtained analyzed understand cylinder flow behavior cfd study also carried using commercial cfd code starcd study compare cylinder flow parameters various engine operating conditions cfd results compared experimental results extent possible cfd predictions found good agreement experimental results therefore cfd analysis extended understand effect various engine parameters cylinder flows found turbulent kinetic energy tumble ratio increased respectively engine speed increased rev min also found turbulent kinetic energy tumble ratio decreased compression ratio increased addition found port orientation rather port areas greater influence cylinder flow parameters elsevier ltd rights reserved
malware forensic analyses embedded cyber physical systems tedious manual processes testbeds commonly designed support additionally attesting physics impact embedded cyber physical system malware formal methodologies currently art chapter describes novel testbed design methodology integrates virtualized embedded industrial control systems physics simulators thereby supporting malware forensic analyses embedded cyber physical systems without risks unlike existing hardware based testbeds resulting soft industrial control system testbeds portable distributable expandable design however embedded system virtualization non trivial especially firmware level solutions vary widely depending embedded system architectures operating systems chapter discusses proposed methodology overcomes challenges virtualizing embedded systems explores benefits via proof concept implementation involving siemens variable step voltage regulator control panel
ipv security issues still ipv ipv unique design characteristics additional impact system network security well potential impact policies procedures address autoconfiguration key feature ipv protocol stack allow hosts generate addresses using confluence information hosts information router advertisement duplicate address detection dad process part address autoconfiguration used check addresses generated already configured nevertheless design dad process vulnerable denial service dos attack leaving hosts unconfigured example host reply neighbor solicitations temporary address causing host consider duplicate eventually reject address various mechanisms send savi introduced address attacks techniques effective still possibilities dos attacks carried new mechanism needed effectively prevent dos attacks dad process paper present detailed design development novel mechanism address shortfalls existing prevention techniques
introduction objective digital modeling slowly becoming everyday orthodontic practice two decades research development basic element orthodontics aim study development use geometric entities digital models diagnosing planning monitoring orthodontic therapy using cad computer aided design systems methods statistical analysis synthesis orthodontic parameters upper lower jaw defining three hypotheses testing application test results three hypotheses confirmed convenience using geometric entities higher accuracy digital models substantial displacement teeth first six months therapy student test first six months distances plane occlusal plane bigger upper lower jaw additionally distances plane medial plane decreased left right side say first phase therapy success jaws wider next four controls parameters showed slight progress statistically significant overall months therapy considerable improvement plane changes distances clinical crown heights small could explained fact therapy using different arches upper molars pushed inside toward palate analyzing computer models could notice plane displacement upper left first molar larger conclusion use geometric entities defining orthodontic parameters gives new possibilities accurate reliable analysis patient orthodontic condition
background endocardial mapping tools use variable interelectrode resolution whereas body surface mapping tools use narrow bandpass filtering bpf map fibrillatory mechanisms established high resolution optical imaging objective purpose study study effect resolution bpf underlying mechanism mapped methods hearts healthy new zealand white rabbits langendorff perfused studied effect spatial resolution bpf location characterization rotors comparing phase singularities detected high resolution unfiltered optical maps fibrillating myocardium decimated filtered maps simulated electrode spacing results decimated maps interelectrode spacing mean number rotors detected decreased respectively lowering resolution led synthesized pseudo rotors may inappropriately identified applying bpf led fewer mean phase singularities detected giving appearance pseudo spatial stability measured translation index bpf without bpf pseudo temporal stability longer duration bpf maps unfiltered maps true underlying fibrillating myocardium mapped conclusion electrode resolution bpf electrograms result distortion underlying electrophysiology fibrillation newer mapping techniques need demonstrate sensitivity analysis quantify degree distortion clinical use avoid inaccurate electrophysiologic interpretation
objective paper builds upon analyses presented three companion papers using data cycles canadian incidence study reported child abuse neglect cis cis ontario child abuse neglect data system ocands examine disproportionality disparity child welfare involvement asian canadian children involved child welfare system methods study used cis data adjusted census child population data examine rates per three disparity indexes population based disparity index pdi decision based disparity index ddi maltreatment based disparity index mdi determine representation child maltreatment investigations asian canadian versus white canadian children involved child welfare system logistic regression analyses conducted determine odds case closure substantiated child maltreatment investigations whether asian ethnicity remained significant controlling child demographics household composition case characteristics clinical concerns results study found asian canadian children underrepresented child welfare system compared white canadian children per asian children canadian population per white children canadian population child welfare involvement asian canadian children almost times likely close investigation white canadian children three disparity indexes pdi ddi mdi showed substantially different results respect representation child maltreatment investigations involving asian canadian versus white canadian children physical abuse sexual abuse neglect emotional maltreatment exposure domestic violence conclusions disproportionality disparity complex phenomena variation results derived different methods calculating representation suggests need greater clarity consistency definitions methodology examining racial disparity child welfare research methodological considerations future child welfare research asian canadian populations discussed elsevier ltd rights reserved
fuzzy set theory effectively manage vagueness ambiguity images degraded poor illumination component study augment mechanism fuzzy set algorithm design propose fuzzy local mean discriminant analysis flmda dimensionality reduction flmda nearest neighborhoods selected local patches local patch flmda redefines fuzzy local class means constructs fuzzy local class within class scatters respectively maximizing difference fuzzy local class scatter fuzzy local within class scatter flmda finds optimal transformed subspace local neighbor relationship preserved time compactness separability enhanced experimental results face database yale face database uci wine dataset polyu palmprint database show flmda outperforms state art algorithms
first results reported statistical tomography kilometer scale irregularities layer high latitude ionosphere amplitude data satellite radio probing basic formulae statistical tomography three dimensionally anisotropic small scale irregularities presented shown anisotropy disguises spatial distribution irregularities insuperable difficulty tomographic reconstruction example shown imaging spatial distribution variance electron density fluctuations kola peninsula february iterative procedure tomographic inversion used reconstruction steps applying statistical tomographic approach outlined
omalizumab recombinant humanized monoclonal antibody immunoglobulin guidelines treatment chronic idiopathic urticaria also known chronic spontaneous urticaria recommend use omalizumab third line therapy addition high doses histamine receptor type antihistamines unsuccessful first second line therapy performed systematic review literature identify studies evaluated efficacy omalizumab treatment chronic idiopathic urticaria controlled real world settings assess potential role preferred therapy pubmed sciencedirect lilacs latin american caribbean health sciences literature google scholar databases searched january november search limited articles published peer reviewed journals english language studies included review omalizumab administered every weeks appears effective safe dosage rapid response time treatment chronic idiopathic urticaria minor adverse effects appears safe offspring pregnant patients received drug however published studies omalizumab sparse future studies warranted findings confirmed larger studies due efficacy safety increased benefit cost ratio omalizumab could become preferred method treatment chronic idiopathic urticaria patients unresponsive antihistamines
scheme reconstruction non polynomial predictors improve forecast chaotic time series algebraic manipulation maple environment basis obtaining accurate predictors beyond different times prediction optional arguments computational routines optimize running analysis global mappings
purpose common evaluate children sustained minor head trauma computed tomography head scalp swelling particular associated intracranial injury subset patients however present delayed fashion often days head trauma soft tissue edema progresses caregiver notices scalp swelling explore value workup setting methods conducted retrospective review prospectively collected cohort children months age presenting texas children hospital scalp swelling following head trauma cases collected year study period june may results seventy six patients comprising patient encounters included study mean age presentation months range days months patients noncontrast head part evaluation emergency medicine well screening nonaccidental trauma nat child protection team common finding head linear nondisplaced skull fracture associated extra axial hemorrhage epidural subdural hematoma found patient encounters patient encounters patients discharged emergency room patients admitted neurologic monitoring patients admitted solely allow nat evaluation patients admitted none experienced neurologic decline nonfocal neurologic exams discharge patient returned delayed fashion neurologic decline patient encounters patient required surgery conclusions pediatric patients months age presenting delayed fashion scalp swelling minor head trauma otherwise nonfocal examination require surgical intervention experience neurologic decline radiographic investigation alter neurosurgical management patients however noted workup child abuse social care may influenced findings suggesting need future development clinical decision making tool help safely avoid imaging setting
ambient intelligence ubiquitous computing carrying world reality almost every object interacts environment either via sensors actuators users must learn interact systems paper presents gesture based interaction approach manipulate objects developed prototype using leap motion controller hand tracking device support vector machine classifier distinguish gestures system evaluated users commands also show review gesture based interaction compare proposals
research addressing links work stress family stress asthma constrained inconsistent evidence failure consider combined exposure work stress family stress primary focus western study populations aimed address knowledge gaps used cross sectional data collected among women five professional groups five chinese cities work stress measured item effort reward imbalance eri questionnaire family stress assessed psychometrically evaluated instrument comprising five items familial conflicts domestic workload asthma operationalized self reports physician diagnosis associations examined multivariable logistic regression estimating odds ratios ors confidence intervals cis high work stress eri score high family stress score median associated asthma respectively women combined exposure versus none somewhat higher odds asthma sole exposure either work stress family stress interaction terms significant continuous variables dichotomized variables present study suggests work stress family stress positively associated asthma women china combined exposure may associated excess asthma occurrence longitudinal studies needed confirm findings explore potential temporal relationships
objectivebased role superior temporal gyrus stg auditory processing language comprehension self monitoring study aimed investigate relationship stg cortical thickness positive symptom severity schizophrenia methodthis prospective meta analysis includes data individuals schizophrenia collected seventeen centres around world contribute enigma schizophrenia working group stg thickness measures extracted weighted brain scans using freesurfer study performed meta analysis effect sizes across sites generated model predicting left right stg thickness positive symptom severity score harmonized saps panss positive scores controlling age sex site secondary models investigated relationships antipsychotic medication duration illness overall illness severity handedness stg thickness resultspositive symptom severity negatively related stg thickness hemispheres left std right std statistically controlling age sex site effect remained stable models including duration illness antipsychotic medication handedness conclusionour findings underline important role stg hallmark symptoms schizophrenia findings assist advancing insight symptom relevant pathophysiological mechanisms schizophrenia
research quantifies rate volume oil gas released two natural seep sites gulf mexico lease blocks depth depth objectives determine variability release rates bubble size five individual vents investigate effects tidal fluctuations bubble release observations autonomous video cameras captured formation individual bubbles released partially exposed deposits gas hydrate image processing techniques determined bubble type oily gaseous mixed oily gaseous size distribution release rate temporal variations observation intervals ranged semiautomatic bubble counting algorithm developed analyze bubble count release rates video data method suitable discrete vents small bubble streams commonly seen seeps adaptable multiple situ set ups two vents birthday candles birthday candles analyzed released oily bubbles average diameter rate bubbles bubbles respectively approximately away within seep site two vents mega plume mega plume analyzed vents released mixture oily gaseous bubbles average diameter rate bubbles bubbles respectively fifth vent rudyville released gaseous bubbles average diameter rate bubbles pressure records mega plume rudyville showed diurnal tidal cycle rudyville vent demonstrated positive correlation diurnal tidal cycle however observations conclusive regarding tidal effects bubble release elsevier ltd rights reserved
since decades cross cultural psychology examines moral values using data standardized surveys assuming values guide human behavior add literature studying link moral values various forms prosocial behavior using data respondents sixth world values survey germany participated online behavioral experiment experiment consists series incentivized tasks allows elaborate association survey measured values three facets observed prosocial behavior evidence boils three findings emancipative values relate higher common pool contributions higher donations charitable organizations secular values linked productive less protective investments results conform key theories reach empirical significance major postindustrial nation conclude important evidence hand highlighting potential combined survey experiment methods establish value behavior links otherwise inexplorable
tunnels constructed using soft ground pressure balance tunnel boring machines london new elizabeth line completed year period single lining design solution developed tunnels using fully gasketed steel fibre reinforced concrete segmental lining suitable use potential ground conditions anticipated along alignment pound billion crossrail project faced many challenges including dealing significant quantities different excavated material minimising environmental impact transportation disposal minimising settlement effects dealing multiple tunnel boring machine launches receptions paper addresses issues tackled comments tunnel boring machine design approach taken survey control outline figures also provided tunnelling rates finally conclusions recommendations made based observations lessons learnt project
study aims develop evaluation process comparing energy performances green non green buildings information building attributes energy consumption multi family housing complexes mfhcs including non certified mfhcs mfhcs accredited green standard energy environmental design seed certification official green building certification south korea mfhcs accredited leadership energy environmental development leed certification applied empirical study data mining techniques applied develop comparison groups considering various building attributes database classified four groups based average enclosed area per household aea shown large aea groups group less energy use intensity eui small aea groups group mean site eui groups significantly different kwh respectively seed leed certified mfhcs considered energy savings respectively compared non certified mfhcs comparative analysis developed groups revealed seed certified mfhcs non certified mfhcs significant differences energy performance therefore energy performance rating system seed revised proposed energy performance evaluation process also useful identifying energy performance buildings elsevier ltd rights reserved
recently luo introduced concept color transfer visual cryptographic scheme ctvcs embedding information color channels conventional vcs luo ctvcs visually decoded halftoned secret image stacking shadow images similar conventional vcs obtained high quality color image however luo ctvcs requires key encoding decoding phases therefore strictly speaking threshold scheme perfect security study solved security problem proposed ctvcs require key experiment indicated proposed solution achieves feature obtaining original color image luo ctvcs addition formally defined contrast security conditions ctvcs demonstrated constructions satisfied contrast security conditions ctvcs elsevier ltd rights reserved
paper presents bit algorithmic adc uses iterative gain enhancement technique uses multiple clock phases increase effective amp gain switched capacitor circuit using amp gives loop gain feedback circuit without gain enhancement application iterative gain enhancement technique boosts loop gain algorithmic adc uses capacitor sharing scaling technique saves power reduces errors adc active area cmos dissipates iterative gain enhancement increases sndr sfdr reducing number gain enhancement iterations lsbs increases conversion rate minor performance degradation
address force law classical electrodynamics material media paying attention force term due time variation hidden momentum magnetic dipoles highlight emergence force component required general theorem deriving zero total momentum static configuration charges currents time disclose impossibility add force term covariantly lorentz force law material media show adoption einstein laub force law resolve issue small electric magnetic dipole density einstein laub force integrates exactly equation like lorentz force inclusion hidden momentum contribution thus none available expressions force moving dipole compatible relativistic transformation force support statement number particular examples respect suggest applying lagrangian approach derivation force law magnetized polarized medium framework approach obtain novel expression force small electric magnetic dipole novel expression generalized momentum latter expression implies two novel quantum effects non topological phases electric dipole moving electric field magnetic dipole moving magnetic field phases general related dynamical effects equal zero classical force dipole vanishing implications obtained results discussed elsevier inc rights reserved
background data chronic spontaneous urticaria csu originate highly selected patient populations treated specialized centres little known csu patient characteristics burden csu routine clinical practice aware world wide antihistamine refractory chronic urticaria patient evaluation ongoing global study designed assess chronic urticaria real life setting objective describe baseline characteristics first german aware patients antihistamine refractory csu methods prospective non interventional study included patients years diagnosis antihistamine refractory csu months baseline demographic disease characteristics comorbidities pharmacological treatments recorded quality life qol assessed using dermatology life quality index dlqi chronic urticaria qol questionnaire angioedema qol questionnaire qol cases angioedema previous healthcare resource utilization sick leave data collected retrospectively results march december patients assessed sites across germany percentage females mean age mean body mass index years respectively mean urticaria control test score one two patients angioedema frequent comorbidities chronic inducible urticaria cindu allergic rhinitis hypertension asthma depression overall patients receiving least one pharmacological treatment including second generation antihistamines first generation antihistamines corticosteroids mean dlqi total total qol scores respectively csu patients reported frequent use healthcare resources including emergency services general practitioners additional allergists dermatologists conclusions clinical relevance study reveals german antihistamine refractory csu patients high rates uncontrolled disease angioedema comorbid cindu undertreated impaired qol rely heavily healthcare resources
background non small cell lung cancers met amplification may respond met inhibitors methods examined lung adenocarcinoma patients mutations amplification status epidermal growth factor receptor egfr anaplastic lymphoma kinase alk ros met clinical characteristics patients met amplification responses met inhibitor therapy studied results patients analyzed positive met gene amplification cases showed intermediate result patients egfr positive met analysis secondary biopsy tissue performed following disease progression met positive patients men age range study years patients started crizotinib cases positive following tyrosine kinase inhibitor therapy patients showed response patient showed response later found concurrent mutation conclusions categories met gene amplification lung cancer patients novo secondary tki therapy patients benefit met inhibitor therapy dual mechanisms resistance egfr mutation met amplification tki therapy may suggest poor prognosis karger gmbh freiburg
sketching natural mode human communication creative processes presents opportunities improving human computer interaction geospatial information systems however use sketch map user input must localized within underlying spatial data set information system base metric map achieved matching process called qualitative map alignment qualitative spatial representations two input maps used establish correspondences sketched object one objects metric map challenge best knowledge method matching qualitative spatial representations suggested far applicable realistic scenarios due excessively long runtimes incorrect algorithm design inability use one spatial aspect time address challenges metaheuristic algorithm uses novel data structures match qualitative spatial representations pair maps present design data structures performance evaluation algorithm using real world sketch metric maps well synthetic data algorithm novel two main aspects firstly employs novel system matrices known local compatibility matrices facilitate computation estimates future size partial alignment allow several types constraints used time secondly heuristic computes higher accuracy state art heuristic task yet requires less computation algorithm also general method matching labelled graphs special case one involving complete graphs whose edges labelled spatial relations results evaluation demonstrate practical runtime performance high solution quality
reservoir simulations always involve large number parameters characterize properties formation fluid many subject uncertainties owing spatial heterogeneity insufficient measurements provide solutions uncertainty related issues reservoir simulations general package called genpack developed genpack includes three main functions required full stochastic analysis petroleum engineering generation random parameter fields predictive uncertainty quantifications automatic history matching genpack developed modularized manner non intrusive package integrated existing commercial simulator petroleum engineering facilitate application computational efficiency improved theoretically introducing surrogate model based probabilistic collocation method technically using parallel computing series synthetic cases designed demonstrate capability genpack test results show random parameter field flexibly generated customized manner petroleum engineering applications predictive uncertainty reasonably quantified computational efficiency significantly improved ensemble kalman filter enkf based automatic history matching method improve predictive accuracy reduce corresponding predictive uncertainty accounting observations
considering traditional power amplifier disadvantage poor reliability flexibility three level pulse width modulation pwm power amplifier based novel field programmable logic gate array fpga algorithm hardware solution proposed power amplifier provide various signals flexibly realize rapid response magnetic suspension spindle micro electrical discharge machining edm paper principle three level pwm amplifier half bridge full bridge power circuit introduced according different functions amplifier divided four function modules include pwm signal generator module voltage signal convert module bootstrap drive module power bridge module pwm signal generator module also divided four sub modules term new fpga algorithm voltage signals converted high speed photo coupler hcpl irs chips applied drive half bridge full bridge power circuits according kirchhoff voltage law period pwm signals duty cycles larger average current half bridge full bridge however ripple half bridge full bridge still less advantage suitable control system magnetic suspension spindle test results average current ripple close theoretical value axial response frequency spindle reach using power amplifier magnetic suspension spindle micro edm achieved axis stroke
great strides made advance understanding neurobiology suicidal behavior neural neuropsychological mechanisms associated well understood purpose current study identify neurocognitive markers context medical rehabilitation performances patients medical rehabilitation center aged examined series neurocognitive executive tasks decision making iowa gambling task igt mental flexibility wcst response inhibition sst working memory digit span self report questionnaires administered suicidal behaviors depression anxiety ptsd well perceived social support suicidal participants performed poorly igt mediation analysis presented significant direct effect decision making suicidal risk well significant indirect effect decision making suicidal risk mediated depressive symptoms bca medium effect size bca despite complexity relationship decision making suicidal risk results suggest clinicians routinely assess decision making abilities adults risk suicide due fact impaired decision making may increase suicidal risk beyond conferred depression
many resource constrained embedded devices wireless sensor nodes require public key encryption digital signature induced plenty research efficient secure implementation elliptic curve cryptography ecc bit processors work study suitability special class finite fields called optimal prime fields opfs lightweight ecc implementation view toward high performance security first introduce highly optimized arithmetic library opfs includes two implementations finite field arithmetic operation namely performance optimized version security optimized variant latter resistant simple power analysis attacks sense always executes sequence instructions independent operands based opf library describe performance optimized security optimized implementation scalar multiplication elliptic curve opfs several security levels former uses gallant lambert vanstone method twisted edwards curves reaches execution time cycles bit opf bit atmega processor whereas latter based montgomery curve executes cycles
topical review article attempt capture recent advances development sustainable hybrid nanocomposite coatings corrosion inhibition structural metals spurred primarily urgent imperative replacing hexavalent chromium also driven concerns regarding environmental impact organic solvents materials criticality considerations need maintain structural integrity function extreme environments renewed impetus towards lightweighting design new coating concepts seen explosion activity discuss varying modes corrosion inhibition drive towards multicomponent nanostructured coatings synergistically unite multiple modes corrosion inhibition within single coating system nanocomposite coatings nanoparticles one phase dispersed within continuous phase usually polymeric matrix provide modular design approach multifunctional coatings provided fundamental challenges dispersion compatibility resolved dint high surface volume ratios incorporation nanoparticles profoundly modifies adjacent polymeric matrix giving rise interphase region modified properties relatively low filler loadings implications incorporating metallic porous metal oxide carbon nanomaterials graphene carbon nanotubes within polymeric matrices explored emphasis active corrosion inhibition availability high quality nanoparticles either electroactive metals graphene carbon nanotubes etc capable serving reservoirs active corrosion inhibitors porous silicon oxide layered double hydroxides halloysite provides unprecedented functionality opportunities multifunctional coatings review emphasizes mechanistic considerations elucidated view towards developing systematic design principles corrosion inhibition outlook future design multimodal coatings presented emphasis emergence rational design nanoparticles advances nanoparticle surface chemistry high throughput testing materials informatics multiscale modeling integrated computational materials engineering approaches
objectives lead pollution serious public health problem world especially plays severe damage role children health apart reducing lead induced damages decrease lead accumulation also critical study first attempt investigate effects meso dimercaptosuccinic acid dmsa potassium iodide chlorophyll chl lead accumulation male mice material methods eighty healthy kunming male mice selected divided randomly groups treated lead acetate pbac intraperitoneally individually combination dmsa chl daily days meanwhile control group treated normal saline whole exposure period day mice sacrificed lead concentrations detected whole blood livers kidneys testicles mice means graphite furnace atomic absorption spectrometry results comparison control group lead concentrations increased mice treated pbac dmsa chl diminished lead accumulation whole blood livers kidneys chl specifically effects lead concentrations testicles male mice conclusions potassium iodide chl food additives effects dmsa reduce lead accumulation male mice effectively results provided experimental evidence vivo preventive measures lead poisoning
background previous emergency contraception studies excluded women report episode unprotected underprotected intercourse thus clinical recommendations based exposure single episode underprotected intercourse objective sought assess prevalence timing underprotected intercourse episodes among women requesting emergency contraception examine probability pregnancy following emergency contraception regimen including placement either copper intrauterine device levonorgestrel intrauterine device simultaneous administration oral levonorgestrel pill women reporting multiple underprotected intercourse episodes including episodes beyond food drug administration approved emergency contraception time frame days study design women seeking emergency contraception negative pregnancy test desired either copper intrauterine device levonorgestrel emergency contraception regimen enrolled prospective observational study enrollment participants reported number timing underprotected intercourse episodes previous days two weeks later participants reported results self administered home pregnancy test results women presented emergency contraception received day intrauterine device reported multiple underprotected intercourse episodes days prior presenting emergency contraception women multiple underprotected intercourse episodes reported median events range two week pregnancy data available participants participant positive pregnancy test pregnancy occurred confidence interval women single underprotected intercourse episode confidence interval women reporting multiple underprotected intercourse episodes includes confidence interval women reporting underprotected intercourse days prior intrauterine device insertion conclusion women seeking emergency contraception clinics commonly reported multiple recent underprotected intercourse episodes including episodes occurring beyond food drug administration approved emergency contraception time frame however probability pregnancy low following day intrauterine device placement
paper proposes cascaded control structure method practical application attitude control multi rotor unmanned aerial vehicle uav cascade control tighter control capability single loop control rarely used attitude control multi rotor uav due input output relation longer simply set point euler angle response transfer function single loop pid control multiply measured signals interactive control loops increase complexity evaluation conventional way design however proposed research method optimize cascade control primary secondary loops pid controller loop investigation currently available pid tuning methods lead selection simple internal model control simc method based internal model control imc direct synthesis method analysis experiments research proposes systematic procedure implement cascaded attitude controller includes flight test system identification simc based pid tuning proposed method validated successfully multiple applications application roll axis lead pid pid cascade control application yaw axis lead pid
work aim detect faces violence scenes order help security control used violent flow vif descriptor horn schunck proposed violence scenes detection first stage applied non adaptive interpolation super resolution algorithm improve video quality finally fire kanade lucas tomasi klt face detector order get low time processing paralleled super resolution face detector algorithms cuda experiments used boss dataset also built violence dataset taking scenes surveillance cameras promising results detecting faces environment benefits proposal
since discovery antitumor activity cisplatin late development metal based drugs enormous burst aim increase anti cancer activity lower side effects promote specific accumulation target cells organs indeed new discipline called medicinal inorganic chemistry born metal ions play fundamental role review provides comprehensive overview various metal complexes targeting translocator protein tspo kda high affinity cholesterol drug binding protein found mostly outer mitochondrial membrane formerly known peripheral type benzodiazepine receptor tspo distribution healthy tissues varies considerably contrast aberrant expression tspo noted several pathological specimens including neurodegenerative diseases cancers findings suggest tspo targeted therapy imaging may utility treatment visualization diseases expressing high density tspo review potential applications cancer diagnosis therapy discussed elsevier rights reserved
abuse related trauma remains global health issue however paucity nationwide reports aim estimate incidence abuse related trauma forward medical care identify characteristics clinical course taiwan patients trauma occurred months diagnosis abuse identified randomly sampled nationwide longitudinal health insurance database million beneficiaries patients demographic data injury pattern medical resource utilization measured stratified age sex compared using chi square test risk factors next trauma event identified using cox regression analysis ninety three patients females identified mean age years including years age first trauma event patients visited emergency room received intervention needed hospital care seven less years old intracranial hemorrhage required intensive care thirty three left complications sequelae required rehabilitation survived victims sexual abuse aged less years men received mood stabilizers antipsychotics reeducative psychotherapy risk factors next trauma event injury involving extremities hazard ratio use antibiotics first trauma event abuse related trauma heterogeneous presentations among subgroups clinicians alert providing timely diagnosis individualized intervention
background contextual factors including gender researchers influence experimental patient pain reports currently known social stimuli influence pain percepts types sensory modalities communication auditory visual olfactory cues associated person perception gender processing produce effects objectives determine whether exposure two forms social stimuli audio visual virtual male female stranger modulates cold pressor task cpt pain reports methods participants similar demographic characteristics conducted cpt solitude without physical presence experimenter another person cpt participants exposed voice image virtual male female stranger voices analogous vocal prosody provided semantic information spoken foreign language differed pitch images depicted middle age male female health care practitioner results male participants females showed higher cpt pain intensity exposed female stimuli compared male stimuli follow analyses showed association social stimuli variability pain sensitivity moderated individual differences subjective self image objective measurements one physical stature discussion findings show exposure virtual gender based auditory visual social stimuli influences exogenous pain sensitivity conclusion research contextual factors vocal properties health care examiners exposure background voices may influence momentary pain perception necessary creating standardized methods measuring patient pain reports clinical settings
present study investigates whether nonverbal behavioral cues hidden criminal intentions build phase criminal act measured end created recordings actors search situation committing mock crime theft bomb placing public crowded area ecological validation used authentic cctv footage real crimes experiment experiment two behavioral clusters pattern movement space nonverbal communication behavior analyzed results showed deviance pattern movement space offenders compared nonoffenders condition well bystanders baseline significant difference nonverbal communication behavior offenders nonoffenders conditions experiment conducted examine two behavior clusters use object self adaptors controlling interpersonal differences results showed increased use object decreased use self adaptors build phase mock crime compared control condition search thus nonverbal behavior offenders seems differ nonverbal behavior nonoffenders however holds conditions valid baseline judging single typical behavioral cue whole cluster nonverbal behaviors pattern movement space use object adaptors general
study explored effects sost gene silencing proliferation apoptosis invasion migration human osteosarcoma cells wnt beta catenin signaling pathway fresh tissues obtained patients osteosarcoma patients osteochondroma human osteosarcoma cells hos saos normal osteoblast hfob selected cultured osteosarcoma cells grouped randomly blank group scrambled control group sost sirna group cell proliferation determined mtt assay cell cycle apoptosis tested flow cytometry transwell scratch test performed determine cell invasion migration qrt pcr western blotting used detect mrna protein expression level sclerostin wnt beta catenin myc cyclin mmp activity caspase assessed immunocytochemistry alkaline phosphatase alp activity measured using nitrophenylphosphate substrate low sost mrna sclerostin protein expression levels observed osteosarcoma tissues cells compared blank scrambled control groups sclerostin expression apoptotic cells alp activity caspase activity regulated proliferation invasion migration abilities osteosarcoma cells evidently enhanced sost sirna group sost gene silencing mrna protein expression levels wnt beta catenin myc cyclin mmp osteosarcoma cells beta catenin protein expression levels nucleus cytoplasm significantly elevated sost gene silencing promotes proliferation invasion migration inhibits apoptosis osteosarcoma cells activating wnt beta catenin signaling pathway
background study aimed investigate efficacy safety nasal packing products silicone tube beschitin aquacel functional endoscopic sinus surgery fess chronic rhinosinusitis crs patients china material methods sixty six crs patients undergoing fess surgery randomly divided groups patients group silicone tube group beschitin group aquacel group postoperative headache nasal pain nasal bleeding swelling nasal mucosa observed month fess surgery bacteriology chronic rhinosinusitis conducted culturing removed nasal packing results vas scores nasal pain silicone tube group lower beschitin aquacel groups volume nasal bleeding beschitin group higher silicone tube aquacel groups adhesion rate nasal cavity beschitin group also higher silicone tube group aquacel group results bacterial culture removed nasal packing showed coagulase negative staphylococci cns frequent silicone tube group beschitin aquacel groups streptococcus pneumonia haemophilus influenza gram negative rods common aquacel group silicone tube beschitin groups conclusions results indicate silicone tube may effective safe beschitin aquacel nasal packing fes surgery crs
wealth governance research examined ceo successions negative organizational consequences arise boards unable effect smooth leadership transitions despite findings empirical anecdotal evidence indicates disruptive successions still common article investigate whether disruptive ceo successions viewed governance lapse board focus specifically succession processes involve use interim leader leverage established research shows pattern board turnover observed wake negative events indicative whether board behaviors practice viewed normative violations theorize audiences disapprove boards use interim ceos therefore expect successions prompt higher rates board turnover observed following noninterim successions however also anticipate relationship moderated situational characteristics surprise ceo departure dynamic industry environment complicate succession planning make audiences accepting board decision rely interim ceo analysis successions publicly traded firms provides support arguments discuss implications findings successions corporate governance
background several states passed medicaid home community based services hcbs waivers expand eligibility criteria available services children autism spectrum disorder asd previous research shown considerable variation waivers little known extent address health care needs children asd objective determine effects medicaid hcbs waivers characteristics unmet health care needs among children asd methods used data waves national survey children health detailed information medicaid hcbs waiver programs states quasi difference difference differences models used determine effects waivers characteristics parent report unmet health care needs children asd compared children without asd results greater waiver cost limits per child estimated costs services enrollment limits associated significant decreases adjusted rate unmet health care needs considerable variation household income level conclusions findings suggest medicaid hcbs waivers significantly decrease unmet need health care among children asd substantially among would otherwise qualify medicaid findings regarding effects specific aspects waivers inform development insurance policies states address needs children asd
paper presents inverse dynamic model estimation based artificial neural network complete new parallel robot manipulator prototype pgk six degrees freedom built petru maior university tirgu mures model estimation parallel robot manipulator performed feedforward artificial neural network control engineering domain control structures need direct inverse model process ensuring process control imposed performances usually determination direct inverse mathematical model difficult impossible task achieved cases different non parametric parametric line line identification methods used solution may support line parametric methods represented feedforward artificial neural networks implementing feedforward artificial neural networks nonlinear autoregressive model exogenous inputs authors investigate possibility choosing optimum parameters characterize neural network approximates better possible model pgk prototype robot finally innovative algorithm developed obtaining optimal configuration parameters set feedforward artificial neural network proposed algorithm helps setting optimal parameters neural network offer high opportunities provide satisfactory identification robot model experimental results obtained structure derived proposed solution demonstrate good approximation related studied system characterized nonlinearities high complexity
purpose activity glymphatic system impaired animal models alzheimer disease evaluated activity human glymphatic system cases diffusion based technique called diffusion tensor image analysis along perivascular space dti alps materials methods diffusion tensor images acquired calculate diffusivities axes plane lateral ventricle body patients evaluated diffusivity along perivascular spaces well projection fibers association fibers separately acquire index diffusivity along perivascular space alps index correlated mini mental state examinations mmse score results found significant negative correlation diffusivity along projection fibers association fibers also observed significant positive correlation diffusivity along perivascular spaces shown alps index mmse score indicating lower water diffusivity along perivascular space relation severity conclusion activity glymphatic system may evaluated diffusion images lower diffusivity along perivascular space dti apls seems reflect impairment glymphatic system method may useful evaluating activity glymphatic system
bone cartilage destruction one key manifestations rheumatoid arthritis although role helper cells processes clear role producing cells cells neglected sought investigate role focusing functional characteristics main producers cytokine synovial cells show frequency synovial fluid tnf cells patients significantly higher compared patients psoriatic arthritis psa frequency peripheral blood cells patients positively correlated disease activity score das serum anticyclic citrullinated peptide anti ccp antibodies igm rheumatoid factor igm levels associated matrix metalloproteinase mmp mmp related induced significantly secretion mmp mmp synovial biopsies sorted cells significantly induced release mmp mmp fibroblast like synoviocytes fls compared medium cells coculture system neutralization tnf resulted significantly less production mmp fls results study indicate new role synovial tnf cells promoting synovial inflammation joint destruction patients importantly blockade combination anti tnf might effective therapy patients inhibiting mmp induced inflammation joint destruction
software project encounters many changes software development life cycle key challenge control changes manage impact project plan budget implementation schedules well developed change control process assist project manager responsible team monitoring changes paper examine number approaches project monitoring control different scenarios project schedules comparison shows effect applying approach cost time project evaluation illustrates integrated software project change management ipcm efficient providing control tracking change requests improve performance monitoring process
designing effective menu systems key ingredient usable graphical user interfaces task generally relies human ability building hierarchical structures however trading different partially opposite guidelines standards practices time consuming exceed human skills problem solving recent advances showing task addressed generative approaches exploit evolutionary algorithms means evolving different unexpected solutions search optimal solutions made trivial due different alternatives lead local optima constraints invalidate large sectors search space make valid solutions sparse problem addressed choosing appropriate algorithm paper face problem searching optimal solutions linear genetic programming particular compare solution conventional approaches based simple genetic algorithms genetic programming experimental results discussed compared human made solutions
background current obesity theories suggest repeated intake highly palatable high sugar foods causes adaptions striatum parietal lobe prefrontal visual cortices brain may serve perpetuate consumption feed forward manner however data humans cross sectional observational leaving little ability determine temporal precedence repeated consumption brain response objective tested impact regular sugar sweetened beverage intake brain behavioral responses beverage stimuli design performed experiment healthy weight individuals randomly assigned consume sugar sweetened beverages daily underwent functional mri sessions completed behavioral explicit hedonic assessments results consistent preclinical experiments daily beverage consumption resulted decreases dorsal striatal response receipt consumed beverage decreased ventromedial prefrontal response logo elicited anticipation decrease prefrontal response correlated increases behavioral disinhibition toward logo consumed beverage daily beverage consumption also increased precuneus response juice logos compared tasteless control suggesting generalized effect toward beverage cues last repeated consumption beverage resulted explicit hedonic devaluation similar nonconsumed beverage conclusions analogous previous reports initial results provide convergent data role regular sugar sweetened beverage intake altering neurobehavioral responses regularly consumed beverage may also extend beverage stimuli future research required provide evidence replication larger sample establish whether neurobehavioral adaptations observed herein specific high sugar nonnutritive sweetened beverages generally related repeated consumption type food
wrky family large family transcription factors tfs found higher plants plays central roles many aspects biological processes adaption environment however little information available family apple malus domestica present study total candidate wrky genes apple genome identified classified three main groups group iii based structure conserved domains group subgroup showed similar exon intron structures motif compositions evolution analysis showed mdwrky genes clustered intensive regions mdwrky formed pairs collinear relationships suggesting tandem segmental duplications played important role evolution diversification wrky gene family apple furthermore expression mdwrky genes apple leaves response biotic stress alternaria alternate hormone treatments salicylic acid methyl jasmonate meja ethephon examined using rna seq qrt pcr results showed mdwrky genes differential expression transcript abundance response alternaria alternata apple pathotype infection moreover pathogen responsive mdwrky genes also changed significantly apple leaves treated meja ethephon plant growth regulations suggesting interaction ethylene eth hormone signaling biotic stress work may provide basis future studies genetic modification wrky genes pathogen resistance apple
trees outside forests tof represent source lignocellulosic biomass received increasing attention recent years studies already investigated potential tof germany spatial explicit analysis specifically baden wuerttemberg still lacking used unique wall wall airborne light detection ranging lidar dataset combined openstreetmap osm data map classify tof federal state baden wuerttemberg similar south western germany furthermore annual biomass potentials tof areas collected available literature calculated mean annual biomass supply tof areas baden wuerttemberg combination remote sensing based classification available literature resulted mean annual biomass supply similar tof baden wuerttemberg classification congruence three reference sites high similar using simple filter technique applied lidar data masking man made objects using osm data contrast available literature revealed high variability biomass potentials supporting demand inventory system still results demonstrate applicability lidar based vegetation mapping value osm data baden wuerttemberg detect man made objects elsevier rights reserved
safety stability hydraulic turbine regulating system htrs hydropower plants become increasingly important since rapid development broad application hydro energy technology paper novel mathematical model francis hydraulic turbine regulating system straight tube surge tank based state space equations introduced study dynamic behaviors htrs system existence possible unstable oscillations model studied extensively presented forms bifurcation diagram time waveform plot phase trajectories power spectrum eliminate undesirable behaviors specified fuzzy sliding mode controller designed hybrid controller sliding mode control law makes full use proposed model guarantee robust control presence system uncertainties fuzzy system applied approximate proper gains switching control sliding mode technique reduce chattering effect particle swarm optimization developed search optimal gains controller numerical simulations presented verify effectiveness designed controller results show performances nonlinear htrs system assisted proposed controller much better commonly used optimal pid controller
even though construction management practice oriented profession always easy cover practical aspects content construction management university texas san antonio lecture based course includes many project related administrative topics students take course previous construction project experience type course typically instructor centered taught passive learning methods recognizing fact different strategies developed every semester make lecture interactive learner centered study construction site trip experience including integrated collaborative learning exercise covering request information rfi content construction management course content previously covered class teamwork exercise also covered teamwork exercise construction site trip examples technical problems encountered execution construction project measure effectiveness site trip survey conducted participating students findings indicate students favored learning experience addition class type exercise good supplementary method learning integration collaborative technical exercise site trip novel portion study american society civil engineers
background etiology chronic fatigue syndrome cfs unclear treatment still big issue exists wide range literature acupuncture moxibustion cfs traditional chinese medicine tcm certain doubts well effectiveness treatment due lack comprehensive evidence based medical proof dispel misgivings current study evaluated systematically effectiveness acupuncture moxibustion treatments cfs clarified difference among chinese herbal medicine western medicine sham acupuncture methods comprehensively reviewed literature including pubmed embase cochrane library cbm chinese biomedical literature database cnki china national knowledge infrastructure may rct clinical research cfs treated acupuncture moxibustion traditional direct meta analysis adopted analyze difference treatments analysis performed based treatment experiment control groups network meta analysis adopted make comprehensive comparisons two kinds treatments primary outcome total effective rate relative risks confidence intervals used final pooled statistics results total randomized controlled trials rcts enrolled analyses traditional direct metaanalysis found comparison chinese herbal medicine cbam combined acupuncture moxibustion meant two types acupuncture moxibustion adopted higher total effective rate similar compared chinese herbal medicine western medicine sham acupuncture sam single acupuncture single moxibustion higher total effective rate similar addition compared sam cbam higher total effective rate similar network meta analyses similar results recorded subsequently ranked treatments high low effective rate order cbam sam chinese herbal medicine western medicine sham acupuncture conclusions treatment cfs cbam sam may better effect treatments however included trials relatively poor quality hence high quality studies needed confirm finding
background patients intermediate uveitis represent heterogenous group characterized wide spectrum etiologies regional differences aim study analyze characteristics patients examined academic center germany methods conducted retrospective analysis clinical records patients intermediate uveitis referred eye center university freiburg diagnosis followed standardization uveitis nomenclature sun criteria data analysis included etiology demographics complications treatment visual acuity results identified patients intermediate uveitis period mean age diagnosis years female mean duration years range month years etiology idiopathic multiple sclerosis sarcoidosis frequent systemic causes etiologies including infectious diseases tuberculosis borreliosis immune mediated conditions vaccination present pattern complications included macular edema cme cataract secondary glaucoma epiretinal membrane formation periphlebitis optic neuritis frequent conjunction treatment comprised local systemic steroids immunosuppressive agents biologics surgery best corrected visual acuity better eyes years follow conclusions german academic center cases idiopathic associated sarcoidosis contrast countries infectious cases rare patients overall visual prognosis favorable even duration long despite numerous complications
dielectric elastomers doped high permittivity fillers ceramic particles achieve enhanced dielectric properties lower voltage required actuation thermodynamic model proposed investigates electromechanical deformation stability dielectric elastomer composites process electromechanical coupling analyzed particular emphasis saturated polarization ceramic fillers modifies instability due electrostriction stability characteristics studied using established principles provide information achieving goal high performance stretchable dielectric actuators elsevier ltd rights reserved
objective among hiv infected persons tenofovir disoproxil fumarate tdf use associated higher risk developing chronic kidney disease ckd lower serum bicarbonate concentrations may precede ckd onset study investigated associations tdf use bicarbonate concentrations bicarbonate ckd risk among tdf users nonusers methods retrospective cohort study hiv infected veterans initiated antiretroviral therapy association tdf use longitudinal bicarbonate concentrations associations bicarbonate incident ckd stratified tdf use never initial later user evaluated results compared tdf users never users faster declines bicarbonate concentrations change bicarbonate mmol per year confidence interval compared mmol per year initial users mmol per year later users low baseline bicarbonate mmol significantly associated ckd risk among tdf never users among tdf users similarly declining bicarbonate concentrations associated higher ckd risk among never users hazard ratio per mmol among tdf users interactions highly significant analyses value conclusion despite associations nephrotoxicity tdf use associated higher serum bicarbonate concentrations longitudinally additionally tdf use obscured strong associations bicarbonate ckd risk hiv infected persons therefore role bicarbonate concentrations tool monitor kidney health hiv infected persons may limited setting tdf use
one main drawbacks existing oscillation damping controllers designed based offline dynamic models adaptivity power system operating condition increasing availability wide area measurements rapid development system identification techniques possible identify measurement based transfer function model online used tune oscillation damping controller model could capture dominant oscillation modes adaptive coordinated oscillation damping control paper describes comprehensive approach identify low order transfer function model power system using multi input multi output mimo autoregressive moving average exogenous armax model methodology consists five steps input selection output selection identification trigger model estimation model validation proposed method validated using ambient data ring data machine bus northeast power coordinating council system results demonstrate measurement based model using mimo armax capture dominant oscillation modes compared mimo subspace state space model mimo armax model equivalent accuracy lower order improved computational efficiency proposed model applied adaptive coordinated oscillation damping control
united states world large numbers nutraceuticals sold people take boost immune response addition almost equal number products sold reduce allergies however consumers indeed physicians aware structure function claim structure function claims labeling claims used describe potential effects dietary ingredient similar substance structure function human body category claims created legislation contained dietary supplement health education act intent supply consumers reasonably substantiated information would allow make educated choices diet health intended weight substantiation claims made conventional prescription pharmaceuticals rather proposed fill gap consumer desire counter supplements foods rigorous generally potent potentially toxic prescription medications legally mandated disclaimer stating food drug administration evaluated structure function claim often leads misinterpretation biologic premise underlying claim absolute requirement conventional rigorous placebo controlled dose response trial may clinical standard typical scientific oriented society might desire reflects attempts fda find common grounds allow consumers use products generally considered safe based historical use biologic comparisons logic indeed need structure function claims straightforward however equal importance nutraceuticals properly labeled accuracy ingredients free contamination safe reasonable body data supports efficacy
multiple sclerosis chronic progressive disabling disorder characterized immune mediated demyelination inflammation neurodegenerative tissue damage central nervous system cns associated frequent exacerbations remissions neurologic symptoms eventual permanent neurologic disability several therapies successful reducing relapses none effective treating patients specific response individual patient one therapies remains largely unpredictable physicians patients forced use trial error approach deciding treatment regimens priori markers predict optimal benefit risk profile individual patient would greatly facilitate decision making process thereby helping patient receive optimal treatment early disease process pharmacogenomic methods evaluate person genetic genomic makeup affects response therapeutics review focuses pharmacogenomics studies used identify biologically relevant differences treatments provide characterization predictive clinical response patterns pharmacogenomics research dependent availability longitudinal clinical research studies concerning glatiramer acetate interferon beta products majority published long term data date described detail studies provided considerable insight prognostic markers associated disease potential predictive markers safety beneficial response published elsevier ltd
elaboration didactic learning units oriented create methodological advantages students could important effort educational process university didactic learning units presented paper objective complementing class notes teacher lectures order improve quality degree education complements students carried work didactic learning units developed topic subjects coursed defense university center marin spain subject materials engineering units try simplify streamline learning curve student common structure explain basic principles topic beginning document competencies bologna process contained educational unit detailed moreover theoretical explanations topic supplemented several schemes figures provide clear view contents furthermore include kind colour speech balloons whose purpose exalt important concepts unit thematic type speech balloons shows anecdotes lesson goal generate interest curiosity student end didactic learning units test basic questions student self assessment subject allows practical exercises didactic learning unit includes solved problems several proposed problems finally educational documents complemented knowledge pills videos uploaded university network available students teacher shows presentation oriented educational learning unit presented
impulsivity widely related socially problematic behaviors psychiatric illness previous studies investigated relationship response inhibition impulsivity however study intensively examined impulsivity correlates automatic sensory processing drive response inhibition sensory inputs sensory gating automatic inhibitory function attenuates neural response redundant sensory information protects higher cognitive functions burst information processing although functions abnormally several clinical populations little evidence supporting changes conjunction impulsivity traits non clinical populations present study recruited healthy adults conduct neurophysiological experiment using paired click paradigm self report scales assessing impulsive behavioral traits auditory stimuli included pure tone also white noise explore differences auditory evoked potential aep responses two stimuli white noise affective pure tones therefore predicted aeps white noise would correlate self reported impulsivity pure tones main findings showed amplitudes significantly correlated self reported reward responsiveness fun seeking respectively white noise stimuli demonstrating higher scoring impulsivity subcomponents related greater frequency domain analyses also revealed greater desynchronization beta band second white noise stimulus associated higher motor impulsivity scores suggesting impulsivity related change associated attentional modulation findings indicate measurement white noise may efficient tool evaluate impulsivity non clinical populations also applied clinical populations
building fractional mathematical models specific phenomena developing numerical analytical solutions fractional mathematical models crucial issues mathematics physics engineering work new analytical technique constructing predicting solitary pattern solutions time fractional dispersive partial differential equations proposed based generalized taylor series formula residual error function new approach provides solutions form rapidly convergent series easily computable components using symbolic computation software method evaluation validation proposed technique applied three different models compared well known methods resultant simulations clearly demonstrate superiority potentiality proposed technique terms quality performance accuracy substructure preservation construct well prediction solitary pattern solutions time fractional dispersive partial differential equations elsevier inc rights reserved
new compact combinatorial coordinate system presented address voxels truncated octahedra body centered cubic grid also lower dimensional cells faces edges vertices almost integer triples address cell grid incidence adjacency relations cells easily captured coordinate values new coordinate system effectively efficiently applied topological shape analysis modeling image processing computer graphics applications elsevier inc rights reserved
use biomarkers proposed diagnosing alzheimer disease recent criteria biomarkers sufficiently investigated justify routine clinical use evaluate literature review clinical validity amyloid positron emission tomography pet imaging using structured framework developed assessment oncological biomarkers homogenous criteria addressed reviews alzheimer disease biomarkers adequate evidence main aims phases rationale use discriminative ability achieved aims phase early detection ability partly achieved phase studies performance representative mild cognitive impairment patients currently ongoing phase studies quantification impact costs still come review highlights priorities pursued enable proper use amyloid pet imaging clinical setting future investigations primarily large phase studies assess utility amyloid pet imaging routine clinical practice elsevier inc rights reserved
data warehouse evolution critical problem present scenario due perpetual transactions change structure arising continual evolving users requirements handling properly type changes crucial process forms core component modern dss therefore updated periodically according different type evolution information sources problem evolving appropriate set views subjected materialized view evolution problem many different materialized view evolution methods proposed literature address issue paper provides survey materialized view evolution methods paper aims studying materialized view evolution relational databases data warehouses well distributed setting defines evolutionary approach highlighting materialized view evolution problem identifying three main dimensions basis classification materialized view evolution methods namely framework architecture iii model design model study reviews architecture based materialized view evolution methods identifying respective potentials limits authors published elsevier
multiculturalism acknowledgment appreciation diversity despite positive consequences often met resistance among majority group members particularly whose race ethnicity central self concept building upon findings multiculturalism lowers white americans prejudice presented abstract relative concrete concept tested whether even concrete forms multiculturalism improve intergroup attitudes across two experiments highly identified white americans exhibited less racial prejudice induced view multiculturalism concrete learning opportunity concrete set policies study concrete ideology generally study effect mediated high identifiers increased perceptions diversity benefits society whole implications prejudice reduction fostering majority group members active involvement diversity relevant issues well applicability studies cultural contexts discussed
quantitative susceptibility mapping qsm increasingly used measure variation tissue composition brain areas body range disease pathologies although qsm measurements originally believed independent echo time used gradient recalled echo gre acquisition derived recent literature sood shown measurements highly dependent number brain regions work systematically investigate possible causes effect analysis apparent frequency qsm measurements derived data acquired multiple tes vivo healthy brain regions cerebral microbleeds cmbs qsm data acquired gadolinium doped phantom qsm data derived idealized simulated phase data apparent frequency measurements optic radiations central corpus callosum compared predicted pool white matter model however model failed fully explain contrasting frequency profiles measured results show dependent qsm measurements caused failure phase unwrapping algorithms around strong susceptibility sources cmbs however healthy brain regions behavior appears result intrinsic non linear phase evolution signal results conclude care must taken deriving frequency qsm measurements strong susceptibility sources due inherent limitations phase unwrapping signal compartmentalization due tissue microstructure content plausible cause dependent frequency qsm measurements healthy brain regions better sampling signal complex models tissue needed fully exploit relationship
paper examines current electrical generation expansion plan ghana compares proposed expansion pathways higher penetration renewable energy technologies adaptation schwartz scenario methodology used develop scenarios analysed using long range alternatives planning leap model scenarios represents policy options generation expansion ghana energy economic environmental analysis three alternative scenarios compared base scenarios undertaken sensitivity results show country follow generation expansion path described renewable energy scenarios could reap economic benefits depending developments fuel prices renewable technology capital cost analysis quantifies benefits derived reduction greenhouse gases scenarios policy implications generation system ghana based results also discussed
behavioural theory consists machine independent postulates characterizing particular class algorithms systems abstract machine model provably satisfies postulates rigorous proof algorithm system stipulated postulates captured abstract machine model class interest article synchronous parallel algorithms class behavioural theory already developed blass gurevich unfortunately though mathematically correct fails convincing intuitively clear postulates really capture essence synchronous parallel algorithms article present much simpler presumably convincing set four postulates synchronous parallel algorithms rather close used gurevich celebrated sequential asm thesis behavioural theory sequential algorithms key difference made extension bounded exploration postulate using multiset comprehension terms instead ground terms formulated signature states addition implicit assumptions made explicit amounts considering states parallel algorithm represented meta finite first order structures article first provides necessary evidence axiomatization presented article characterizes indeed whole class synchronous parallel algorithms formally proves parallel algorithms captured abstract state machines asms proof requires recourse methods finite model theory means shown critical tuple defines update update set also every bther tuple logically indistinguishable defines update update set elsevier rights reserved
aim developing autonomous miniature hovering flying robots capable navigating unstructured gps denied environments major challenge miniaturization embedded sensors processors allow platforms fly paper propose novel ego motion estimation algorithm hovering robots equipped inertial optic flow sensors runs real time microcontroller enables autonomous flight unlike many vision based methods algorithm rely feature tracking structure estimation additional distance sensors assumptions environment method introduce translational optic flow direction constraint uses optic flow direction scale correct inertial sensor drift changes direction solution requires comparatively much simpler electronics sensors works environments geometry describe implementation performance method hovering robot equipped eight optic flow sensors show used closed loop control various motions
treatment neuropathic pain using topical formulations still infancy topical analgesic formulations become available clinical use among analgesic creams still rare unfortunate analgesic creams offer number advantages patches convenience ease adapting frequency application dose rubbing cream hurts involves patient much therapeutic process compared patches localized treatment modalities although literature supporting efficacy safety analgesic creams mostly compounded growing since last decade pain physicians yet noticed appreciated therapeutic potential clinical value creams probably due prejudice topical application need act transdermally less slow release formulation patches delivering opioids discuss prejudice show multiple important targets skin reached topical analgesic anti inflammatory compounds keratinocyte one targets specifically targeting keratinocyte analgesia seems possible effective safe thus topical analgesic creams may hold promise novel treatment modality neuropathic pain
benzene exposure represents potential risk children health apart known carcinogen humans group according iarc scientific evidence suggesting relationship benzene exposure respiratory problems children results still inconclusive inconsistent study aims assess determinants exposure indoor outdoor residential benzene levels relationship respiratory health infants participants year old infants inma cohort valencia spain residential benzene exposure levels measured inside outside dwellings means passive samplers day campaign persistent cough low respiratory tract infections wheezing first year life covariates dwelling traits lifestyle factors sociodemographic data obtained parental questionnaires multiple tobit regression logistic regression models performed assess factors associated residential exposure levels health associations respectively indoor levels higher outdoor ones respectively considerable percentage dwellings indoors outdoors respectively surpassed guideline derived lifetime risk leukemia monitoring season maternal country birth parental tobacco consumption associated residential benzene exposure indoor outdoors additionally indoor levels associated mother age type heating outdoor levels linked zone residence distance industrial areas adjustment confounding factors significant associations found residential benzene exposure levels respiratory health infants hence study support hypothesis benzene exposure effect respiratory health children even highlights public health concern related personal exposure levels since considerable number children surpassed abovementioned guideline benzene exposure authors published elsevier ltd
background purpose paper describe variation months year major depressive episode mde prevalence important aspect epidemiological description mde one received surprisingly little attention literature evidence seasonal variation mde prevalence weak contradictory studies sought estimate prevalence seasonal affective disorder using cut points applied scales assessing mood seasonality rather mde approach align modern classification seasonal depression diagnostic subtype major depression rather distinct category also studies may lacked power detect seasonal differences addressed limitations examining month specific occurrence conventionally defined mde pooling data large epidemiological surveys enhance precision analysis method data two national survey programmes national population health survey canadian community health survey used providing ten datasets collected together including studies assessed mde using short form version composite international diagnostic interview cidi major depression one exception survey used non abbreviated version cidi proportion episodes occurring month evaluated using items diagnostic modules statistical methods addressing complex design features trials overall month specific pooled estimates associated confidence intervals estimated using random effects meta analysis gradient assessed using meta regression model included quadratic term results considerable sampling variability month specific proportions estimated individual survey datasets however across various datasets sufficient homogeneity justify pooling estimated proportions producing large gains precision seasonal variation clearly evident pooled data highest proportion episodes occurred december january february lowest proportions occurred june july august proportion respondents reporting mde january higher august suggesting association implications health policy pattern persisted stratification age group sex latitude conclusions seasonal effects mde may obscured small sample sizes prior studies canada mde clear seasonal variation yet addressed planning services results suggest availability depression treatment higher winter summer months
two studies provided evidence decision report ambiguous case child abuse affected subsequent memory case information participants falsely recognized details presented original information schematically associated child abuse moreover post decision information child later died abuse influenced memory reports participants chosen report case increasing reports false schema consistent details suggests false decision consistent memories primarily due sense making schematic processing rather motivation justify decision present findings points important mechanism decision information become distorted retrospect emphasize difficulties improving future decision making contemplating past decisions results also indicate decisions may generate false memories apparent absence external suggestion misleading information implications decision making theory applied practices discussed
network coding important cloud storage technique recover data small repair bandwidth high reliability compared existing erasure coding replication methods however regardless data recovery technique used repaired data geographically distributed cloud storage system easy eavesdropped transmission link local datacenter remote backup site kind network security issue called link eavesdropping paper network coded cloud storage system propose systematic design methodology determine important data recovery system parameters specified security level analysis present performance curves relate remote repair bandwidth number coded data fragments consequently important system parameters network coded data recovery system including number storage nodes link capacity datacenter backup site precisely designed satisfying different security level requirements
prior studies suggest increased urine albumin associated heightened fracture risk women results men unclear used data osteoporotic fractures men mros prospective cohort study community dwelling men aged years evaluate association increased urine albumin subsequent fractures annualized rate hip bone loss calculated albumin creatinine ratio acr urine collected visit subsequent clinical fractures ascertained triannual questionnaires centrally adjudicated review radiographic reports total hip bmd measured dxa visit average years later estimated risk incident clinical fracture using cox proportional hazards models annualized bmd change using ancova men calculable acr acr albuminuria acr macroalbuminuria mean years follow men incident clinical fracture multivariate adjusted models neither higher acr quintile trend albuminuria versus albuminuria associated increased risk incident clinical fracture increased urine albumin borderline significant multivariate adjusted positive association rate total hip bone loss modeled acr quintiles modeled albuminuria versus albuminuria macroalbuminuria associated higher rate annualized hip bone loss compared albuminuria annualized loss men acr limited prevalence macroalbuminuria precluded reliable estimates fracture associations community dwelling older men found association urine albumin levels risk incident clinical fracture found borderline significant positive association rate hip bone loss american society bone mineral research
article reviews research contributions political science communication topic nonverbal communication politics review opens research content nonverbal communication considers studies examining moderates impact nonverbal aspects political messages attitudes behavior mechanisms underpin effects period reviewed research shows nonverbal channel rich political information consequential political decision making particularly certain circumstances low information conditions visuals affect political decisions cognitive emotional routes review article also identifies several directions research required particularly regard social media nonvisual aspects nonverbal communication interplay visual verbal arguments mechanisms behind effects nonverbal communication
purpose review purpose review examine relationship headaches epilepsy well headaches psychogenic non epileptic seizures pnes emphasis placed clinical characteristics pathophysiology treatment recent findings epilepsy headaches common disorders occur often would expected chance overlapping clinical features migraine epilepsy well evidence shared underlying mechanisms proposed theories shared etiology include ion channel dysfunction glutamatergic mechanisms mitochondrial dysfunction recent diagnostic classification systems recognized relationship headaches epilepsy ictal headaches rare raise suspicion pnes headaches patients epilepsy undertreated despite evidence efficacy abortive headache medications summary comorbid headaches epilepsy relatively common population presenting neurologist patients headaches epilepsy pnes receive appropriate treatment often includes mutually beneficial preventative therapy includes abortive headache treatment
home environment influence childhood allergies respiratory health little information associations early life exposure home new onset remission asthmatic allergic symptoms preschool children questionnaire survey performed random cluster sample preschool children urumqi china information home environment perceptions odors indicators pollution sources children health wheeze rhinitis eczema collected first years life last year answering questionnaire one parents another guardian child associations home environment first years life new onset remission childhood symptoms analyzed multiple logistic regression home environment factors reported first years life consistently positively associated new onset symptoms negatively associated remission symptoms visible mold moldy odor air dryness stuffy odor parental smoking associated new onset symptoms factors negatively associated remission symptoms conclusion mold contamination home moldy odor visible mold poor indoor air quality stuffy odor air dryness exposure environmental tobacco smoke ets first years life increase incidence asthmatic allergic symptoms decrease remission symptoms preschool children else rights reserved
knowledge autumn phenology response climate variability currently limited one way improve understanding autumn phenology landscape scale investigate autumn vegetation dynamics based multiple vegetation indices remote sensing data study derived two autumn phenological metrics phenometrics onset drying dormancy semi arid grasslands modis normalized difference water index ndwi time series onset drying represents start decline vegetation metabolism autumn onset ndwi based dormancy signifies end metabolic activity ndwi based phenometrics compared enhanced vegetation index evi based phenometrics northeastern china influences climatic variability autumn phenology analyzed using partial correlation analysis found general onset drying slightly later onset evi based senescence strongly correlate precipitation mean minimum temperature august onset ndwi based dormancy average time lag seven days relative onset evi based dormancy moreover showed much stronger response mean minimum temperature september evi based dormancy colder autumn generally advanced onset ndwi based dormancy little effect onset evi based dormancy study area results suggest phenological studies using ndwi could expand understanding land surface phenology furthermore considering different responses onset ndwi evi based dormancy climate variability combination phenometrics could contribute study ecosystem processes carbon cycle semi arid grasslands elsevier rights reserved
among available tools estimating ecological impacts discharge alteration hydraulic habitat models link hydraulic models streams biological models reflect preferences organisms hydraulics simplification habitat models enables application catchment scale estimating impacts habitats discharge abstraction management seine normandie catchment france propose original linkage distributed hydrological model fish species distribution model hydraulic habitat models show groundwater abstraction catchment cause moderate alteration low flows median weak alteration usable habitats fish median however spatial distribution alterations helps identify regions impacts stronger habitat alteration around due strong abstraction presence demanding fish species uncertainty analysis indicates results interpreted regional scale allow identifying regions would deserve detailed analyses results open many perspectives taking account habitat issues quantitative water management catchment scale
objectives objective prospective comparative cohort study establish effectiveness safety erbium yag yag laser treatment genitourinary syndrome menopause compare established topical estriol treatment methods fifty patients genitourinary syndrome menopause divided two groups estriol group received treatment estriol ovules weeks laser group first treated weeks estriol ovules times per week hydrate mucosa received three sessions yag laser non ablative mode biopsies taken months post treatment maturation index maturation value recorded months post treatment vas analysis symptoms recorded months post treatment results statistically significant reduction assessed symptoms observed laser group follow ups months post treatment significant improvement maturation value decrease laser group detected months treatment improvement endpoints pronounced longer lasting laser group histological examination showed changes tropism vaginal mucosa also angiogenesis congestion restructuring lamina propria laser group side effects minimal transient nature groups affecting patients laser group patients estriol group conclusions results show yag laser treatment successfully relieves symptoms genitourinary syndrome menopause results pronounced longer lasting compared topical estriol treatment authors lasers surgery medicine published wiley periodicals inc
parasite infection often results alterations host behaviour changes vary greatly magnitude slight shifts time spent host performing given activity appearance novel behaviours effects parasites differ age physiological condition host rickia wasmannii ectoparasitic fungal symbiont myrmica ants covers whole body surface host reduces lifespan fungus present young old individuals making optimal subject study age related parasitic effects tested effect fungal infection locomotory activity myrmica scabrinodis ant different age categories fat content workers measured proxy physiological status based findings old workers bore thalli leaner young individuals tended move higher speeds lower degree meandering young individuals covered smaller distances slower speeds higher degree meandering contrary expectations infection intensity wasmannii affected neither fat content locomotory activity ant workers however two age classes seem different strategies regards relationship fat content distance covered results suggest characteristics locomotory activity differ age classes many respects also influenced physiological status parasitism wasmannii seem straightforward effect variables studied elsevier ltd rights reserved
along continuous improvement various properties green building amount data big operation maintenance green buildings need use data analyze make decisions premise data analysis data collected system accurate paper data power generation system air conditioning system green building analyzed pre treatment using cook distance algorithm based deletion model improved lof algorithm analysis abnormal according characteristics data establishing real time detection model abnormal data
majority cardiac fibroblasts mature mammalian heart derived epicardium prenatal development reactivate developmental programs progression fibrotic disease addition epicardial activation proliferation fibrosis occur ischemic hypertensive injury review cellular molecular mechanisms control epicardium derived cell lineages development disease focus cardiac fibroblasts article part special issue entitled fibrosis myocardial remodeling elsevier ltd rights reserved
present phase field model simulate grain growth occurring polysilicon channel process one critical steps fabricating vertical nand flash memory process called solid phase crystallization annealing following depositing amorphous silicon film side wall channel hole prediction grain structures grain size great importance process engineers grain boundaries degrade bit line current flowing along channel set allen cahn equations polycrystalline film numerically solved finite difference method using parallel computing platform model could successfully reproduce experimental trends film thickness dependence final grain size
background aim study determine plasma levels cyclooxygenase cox visfatin different stages different subtypes migraine headaches compared control group elucidate pathological mechanisms involved material methods recruited case control cohort adult migraine patients age matched gender matched healthy controls migraine patients divided two groups headache attack period group group headache free period group group two groups divided subgroups according whether aura symptoms solid phase double antibody sandwich enzyme linked immunosorbent assay elisa used measure plasma levels cox visfatin statistical analysis performed using spss results plasma levels cox visfatin headache attack period group significantly higher headache free period group control group significant differences headache free group control group significant differences plasma levels cox visfatin subgroups headache attack period aura subgroup headache attack period without aura sub group conclusions cox visfatin participated pathogenesis migraine headaches presence aura effect serum levels cox visfatin
wireless sensor networks wsns consists large number spatially distributed configurable sensors meet requirements industrial military precision agriculture health monitoring applications ease implementation maintenance cost transmission data requires energy quality service qos aware routing ensure efficient use sensors effective access gathered information design wsns considering issues challenging task leads complex algorithm design difficult analyze analytical methods physical measurements deploying test beds supposes huge effort deed computer aided simulation feasible approach analysis wsns addressed different types simulators along key features applicability simulation numerous application areas
goal study evaluate influence hypothyroidism induced mmi gestation gestation plus lactation testis relation leptin rats six eight pups killed days age statistical analysis one way anova followed holm sidak post hoc test used hypothyroidism resulted significant reduction fsh testosterone increase leptin serum levels significant decrease star fshr lhr pstat socs protein expression fertility parameters conclude hypothyroidism associated reduction steroidogenesis spermatogenesis leading low fertility potential animals outcome could consequence low pituitary stimulus testicular response probably related leptin hormone since signaling pathway regulated testis elsevier ireland ltd rights reserved
recognition texts scenes one important tasks many computer vision applications though different scene text recognition techniques developed scene text recognition generic condition still open challenging research problem one major factor defers advance research area character touching many characters scene images heavily touched segmented recognition paper proposed novel scene text recognition technique performs word level recognition without character segmentation proposed technique three advantages first converts word image sequential signal scene text recognition second adapts recurrent neural network rnn long short term memory lstm technique widely used handwriting recognition recent years third integrating multiple rnns accurate recognition system developed capable recognizing scene texts including heavily touched ones without character segmentation extensive experiments conducted number datasets including several icdar robust reading datasets google street view dataset experiments show proposed technique capable recognizing texts scenes accurately
type lectins ctls represent complex family animal human lectins comprises different groups evolution ctls developed diversification cover broad range glycan ligands however ligand binding ctls necessarily restricted glycans ctls also bind proteins lipids inorganic molecules ice crystals ctls share common fold harbors contact sugar invariant residues phylogenetically conserved pattern vertebrates ctls numerous functions including serum glycoprotein homeostasis pathogen sensing initiation immune responses myeloid ctls innate immunity mainly expressed antigen presenting cells play prominent role recognition variety pathogens fungi bacteria viruses parasites however myeloid ctls macrophage inducible ctl mincle clec may also bind self antigens thus contribute immune homeostasis ctls induce pro inflammatory responses thereby lead activation adaptive immune responses ctls act inhibitory receptors dampen cellular functions since ctls key players pathogen recognition innate immunity targeting ctls may promising strategy cell specific delivery drugs vaccine antigens modulate immune responses
background mortality septicaemia meningitis encephalitis caused listeria monocytogenes twenty one cases invasive listeriosis associated alemtuzumab including least patients multiple sclerosis published reported world health organization case safety reports database three cases fatal including least one patient treated multiple sclerosis case presentation report patient multiple sclerosis developed pyrexia nausea abdominal discomfort hours third last infusion second alemtuzumab cycle infusion related reaction suspected patient however eaten soft cheese raw sausage days prior treatment monocytogenes septicaemia diagnosed based positive blood cultures conclusion listeriosis associated alemtuzumab potentially fatal condition mimic infusion related reaction previously reported cases symptoms started rapidly last infusion suggesting patient already carried bacteria prior alemtuzumab infusions summary product characteristics recommends patients avoid foods associated listeria least month treatment recommendation include also last weeks prior treatment
background health literacy linked health outcomes across population groups around world nepal low income country experiences double burden highly prevalent communicable well non communicable diseases world health organization positioned health literacy key mechanism meet health related sustainable development goal sdg however little known status health literacy developing countries nepal paper aims review potential health literacy address sdg nepal methods rapid review conducted using knowledge action evidence summary approach articles included review reporting barriers health care engagements nepal published english language january december results barriers healthcare engagement included knowledge education strong factors followed culture gender roles quality service cost services barriers influence nepalese community access engage services make enact healthcare decisions individual level family level factors directly linked health literacy health literacy pivotal determinant understanding accessing using health information health services important health literacy needs people addressed conclusion locally identified developed health literacy interventions may provide opportunities systematic improvements health address impediments healthcare nepal research health literacy implementation health literacy interventions may help reduce inequalities increase responsiveness health systems could potentially facilitate nepal meet sustainable development goals currently little place health literacy impact sdg paper generates insights health literacy potential role
organizational interventions aiming improving employee health wellbeing proven challenging evaluate analyze intervention processes two methodological approaches widely used quantitative often questionnaire data qualitative often interviews methods established tools distinct epistemological properties enable illuminate different aspects organizational interventions paper use quantitative qualitative process data organizational intervention conducted national postal service intervention process measure questionnaire well extensive interview study used analyze type knowledge intervention processes two methodologies provide discuss strengths weaknesses well potentials mixed methods evaluation methodologies
large amount silicon form silicon scraps wasted annually photovoltaic industry presence silicon carbide inclusions silicon carbide inclusions must eliminated silicon scraps recycled study investigated electromagnetic separation silicori carbide inclusions multicrystalline silicon imposition supersonic frequency magnetic field silicon carbide particles tend migrate ingot side top bottom central region ingot increasing holding time separation process penetrating aluminum react silicon carbide dissolve inclusions work separation efficiency reaches holding time min method potentially effective means recycling silicon scraps elsevier ltd rights reserved
background biomass burning shown amajor source poor indoor air quality iaq developing higher income countries across world specifically wood burning cooking heating contributes high indoor concentrations fine particles aerodynamic diameters coarse particles aerodynamic diameters pmc particulate matter endotoxin predominantly found within coarse fraction airborne particulate matter associated proinflammatory effects adverse outcomes among susceptible populations aim study assess efficacy air filter interventions reducing indoor pmc pmc associated endotoxin concentrations homes using wood stove primary heating results homes randomized receive roomair filtration units either high efficiency filter active lower efficiency fiberglass filter placebo active filter intervention showed reduction indoor concentrations reduction relative placebo intervention active placebo filters effective substantially reducing indoor concentrations pmc average reduction active placebo filters respectively pmc associated endotoxin concentrations average reductions respectively conclusions findings support use high efficiency air filtration units reducing indoor homes using wood stove primary heating also discovered using lower efficiency lower cost filter alternatives effective reducing pmc airborne endotoxin homes burning biomass fuel published elsevier
background outcomes studies season birth bias eating disorders inconsistent inconsistency explained differences methodologies resulting different types effect sizes aim current study facilitate comparison using methodology samples two studies differing conclusions methods statistical analyses used study applied samples study resulting effect sizes cramer odds ratio compared discussed results studies cramer ranged ranged according common conventions cramer ors considered small conclusion marker one potential risk factors observed effects considered small reanalysed allowing direct comparisons studies contrasting conclusions converge towards absence support season birth bias patients
hybrid electric vehicles assumed play major role future mobility concepts although sales numbers increasing little emphasis laid recycling key components power electronics electric motors permanent magnet synchronous motors contain considerable amounts rare earth elements recovered conventional recycling routes although recycling could large economic environmental strategic advantages industrial recycling permanent magnets available western countries moment regarding essential steps dismantling electric vehicles well extraction magnets rotors little published paper therefore presents discusses different recycling approaches recycling ndfeb magnets hybrid electric vehicles many results stem german research project recycling components strategic metals electric drive motors
neuroscientific evidence indicates human social functioning supported distributed network frontal temporal brain regions undergoes significant development childhood adolescence clinical studies individuals early brain insults ebi frontotemporal regions suggest lesions may interfere maturation sociocognitive skills lead increased sociobehavioural problems however little attention focussed direct assessment sociocognitive skills moral reasoning following focal ebi present study performance patients focal ebi years compared demographically matched controls basic neuropsychological measures executive functions sociocognitive tasks moral reasoning moral decision making empathy parent reports sociobehavioural problems social adaptive skills patients focal ebi significantly lower levels moral reasoning maturity moral decision making empathy matched controls differ general measures cognition parents also reported increased sociobehavioural problems findings suggest focal ebi frontotemporal regions result reduced sociocognitive capacities specifically moral reasoning increased vulnerability sociobehavioural problems
paper area competent field programmable gate array fpga execution scheme elliptic curve cryptography ecc depicted numerous limitations traditional encryption algorithms rivest shamir adleman rsa advanced encryption standard aes respect security power resources real time performance ecc mounting imperative cryptography gives idea promise substitute rsa paper ecc processor architecture galois fields gfs multitalented bit serial multiplier depicted accomplishes greatest area power performance traditional digit serial multiplier addition vigilant scheduling operation employed diminish involvedness logic unit operations ecc processor anticipated architecture executed vertex fpga expertise xilinx software demonstrate results perk performance enhanced design contrasting traditional design
paper presented comparative study system designed implemented monitoring toxic emissions resulting industrial processing leather existing systems system consists sensors data acquisition boards industrial ethernet connection process computer specially designed software application runs process computer system compared systems taking consideration specific criteria advantages disadvantages approach presented first criterion communication data acquisition boards process computer cable wireless second criterion process computer failure case analyzed different approaches prevent loss data collected sensors data acquisition boards received process computer failed third criterion represents autonomy data acquisition boards analyzed cases running batteries connected electrical network cases together final criterion represents number sensors process computers case investigated possibility using cluster process computers order connect many sensors required results study used set path future improvements system
paper first time developed analytical model surface potential double gate tunneling field effect transistors tfets considering effect localized charges sio interface near source channel junction surface potential model minimum tunneling width evaluated used extract threshold voltage using constant current method model applied study effect localized charges threshold voltage tfets captures shift threshold voltage due change localized charge region length localized charge density polarity accuracy proposed model verified using technology computer aided design simulations
aim current study investigate relationship ambivalent sexism specifically hostile sexism benevolent sexism religiosity attitudes toward childlessness muslim undergraduate students sample consisted women men turkish islamic undergraduate students studying north cyprus aged years old originating various regions turkey participants completed measures ambivalent sexism attitudes toward childlessness well rated level religiosity expected due emphasis traditional gender roles benevolent sexism high islamic religiosity would predict negative attitudes toward childlessness turkish sample results showed women higher levels religiosity benevolent sexism predicted negative attitudes toward childlessness whereas men benevolent sexism alone predictive negative attitudes toward childlessness results discussed accordance literature ambivalent sexism religion islam
given different roles women men play households communities strategies improve food security build adaptive capacity need take gender differences account many developing countries local organizations role play however degree overlap among priorities men women organizations including non governmental bodies local government offices agencies working community generally known know whether organizations strengthening adaptive capacity men women effectively equally using gender disaggregated data arising community level participatory research organizational level interviews sites across west africa east africa south asia conduct cross regional analysis local organizational landscapes relate livelihoods food security find regions women tend value local organizations highly thus appear less connected external organizations men additionally women perception food security broader men going beyond production focus local organizations food security stated objective focus production marginalize alienate women given effects climate change predicted food security development organizations consider differing priorities men women use gendered perspective building adaptive capacity respond climate change maintain improve food security work perhaps effectively implemented existing community groups
propose approach designing formalizing implementing top existing multiagent systems without interfering sentinels detect errors fail uncontrolled multiagent systems controllers identify particular situations ambient intelligence ami systems formalism use representing expected patterns actions trace expressions extended features dealing exceptions timeouts handlers paper provide syntax semantics extended trace expressions formalism examples use different contexts fail uncontrolled ami systems
brain imaging postmortem studies indicated white matter abnormalities may contribute pathology pathogenesis depression however study quantitatively investigated white matter changes depression rats current study used chronic unpredictable stress cus model depression body weight sucrose preference test spt scores assessed weekly upon successfully establishing cus animal model animals tested using spt open field test oft transmission electron microscopy unbiased stereological methods used investigate white matter changes rats compared control group body weight sucrose preference cus rats significantly decreased respectively oft total time spent total distance traveled inner area cus rats significantly lower control group respectively stereological results revealed white matter volume total volume total length mean diameter myelinated fibers white matter cus rats significantly decreased compared control rats respectively results study suggested white matter atrophy disruption myelinated fibers white matter may contribute pathophysiology underlying depression might provide new targets development novel therapeutic interventions depression
amr sawalha professor internal medicine marvin betty danto research professor connective tissue research university michigan department internal medicine division rheumatology also holds faculty appointments center computational medicine bioinformatics graduate program immunology university michigan recently appointed guest professor central south university changsha china received medical degree jordan university science technology completed residency training internal medicine university oklahoma health sciences center fellowship rheumatology university michigan research focus genetics epigenetics complex autoimmune inflammatory diseases including lupus systemic vasculitis authored peer reviewed manuscripts book chapters review articles editorial board several journals field elected member american society clinical investigation received numerous awards including edmund dubois memorial lectureship award american college rheumatology recognition work lupus chair lupus foundation america research subcommittee member vasculitis foundation medical scientific advisory board also provides clinical care teaching rheumatology outpatient inpatient services director nih funded rheumatology training grant university michigan
searching new efficient algorithms solve complex optimization problems big data scenarios priority especially search space increases exponentially problem size making impossible find solution mere blind search networks evolutionary processors nep formal framework formed highly parallel distributed computing models inspired abstracted biological evolution able solve hard problems efficient way however nep expressive enough model quantitative aspects present many problems paper propose nepo new model based nep evolutionary processors nepo deals class data able solve hard optimization problems defines novel selection process based quantitative filtering strategy present linear time solution well known complete optimization problem knapsack problem order demonstrate nepo advantages result suggests nepo quantitative filtering suitable tackle practical solutions optimization problems order deploy highly scalable distributed computational platforms elsevier rights reserved
main result paper simulation algorithm quite general constraints transforms algorithms running congested clique model algorithms running mapreduce model case study applying simulation algorithm first present distributed delta coloring algorithm running congested clique rounds delta log log log logn rounds otherwise applying simulation theorem congested clique coloring algorithm yields round delta coloring algorithm mapreduce model apply simulation algorithm congested clique algorithms including ruling set metric facility location algorithms berns icalp simulation algorithm illustrates natural correspondence per node bandwidth congested clique model memory per machine mapreduce model congested clique generally network congest model major impediment constructing fast algorithms logn restriction message sizes similarly mapreduce model combined restrictions memory per machine total system memory dominant effect algorithm design showing fairly general simulation algorithm highlight similarities differences models elsevier rights reserved
general numerical solution dynamics microring resonator modulators proposed using signal flow graphs fields calculated according signal flow graphs solution suitable many kinds microring resonator modulators coupling modulation resonators symmetric mach zehnder interferometer coupling regions studied method results show method provides theoretical rigor wide applicability microring resonator devices
service based systems become popular software industry software engineering widely acknowledged requirements quality attributes performance security reliability significantly impact design software systems study explores role quality attributes design service based systems investigate significance quality attributes designing service based systems quality attributes addressed design decisions across application domains related aspects software development architecture documentation conducted descriptive survey survey done online questionnaire targeting practitioners furthermore included researchers practical design experience obtained valid responses survey participants consider quality attributes functionality equally important treat quality attributes explicitly rather implicitly furthermore dependability relevant quality attribute service based systems find quality attributes particularly important specific application domains quality attributes addressed hoc decisions rather established architecture design patterns technologies decision alternatives considered making architectural decisions address quality attributes results partially confirm anecdotal evidence current literature also strengthen previous claims providing empirical evidence results point future research directions exploring impact decision types well quality attributes achieved implications practitioners training makes difference quality attributes treated
one fourth one half parents children attention deficit hyperactivity disorder adhd adhd complicating delivery evidence based child behavioral pharmacological treatments article review literature examining relation parent adhd outcomes following behavioral pharmacological treatments children adhd also review research incorporated treatment parent adhd either alone combination child treatment goal improving parenting child outcomes finally offer recommendations future research relation parent adhd evidence based treatment outcomes children purpose advancing science informing clinical care families
ignitor program maintains objective approaching ignition conditions incorporating systematical advances made relevant high field magnet technology experiments high density well confined plasmas present machine design additional objective charting development high field line experiments goes alcator machine ignitor device rationale class experiments aimed producing poloidal fields highest possible values compatible proven safety factors known plasma instabilities given basis favourable properties high density plasmas produced systematically line machines envisioned future line based novel high field superconducting magnets includes possibility investigating advanced fusion burn conditions plasmas ignitor designed considering detailed machine design carried coppi nucl fusion advances made different areas physics technology relevant ignitor project reported included within following sections present paper main components issues assembly welding procedures robotics criteria non linear feedback control simulations three dimensional structures disruption studies icrh dedicated diagnostics systems anomalous transport processes including self organization fusion burning regimes zero dimensional model tridimensional structures thermonuclear instability control provisions superconducting components present machine envisioned experiments high field superconducting magnets
schizophrenia characterized increased mortality suicidality decisive factor analysis cortical thickness folding elucidate neuroanatomical correlates suicidality schizophrenia yet performed searched relevant brain regions differences patients suicide attempts patients without suicidal thoughts healthy controls schizophrenia patients suicide attempters non suicidal age gender matched healthy controls included suicidality documented clinical interview chart review participants underwent weighted mri scans whole brain node node cortical thickness folding estimated freesurfer software compared additionally three group comparison prefrontal regions interest performed spss using multifactorial glm compared healthy controls patients showed typical pattern cortical thinning prefronto temporal regions altered cortical folding right medial temporal cortex patients suicidal behavior compared non suicidal patients demonstrated pronounced cortical thinning right dlpfc superior temporal cortex comparing cortical thickness suicidal patients non suicidal patients significant cortical thinning additionally found right superior middle temporal temporopolar insular cortex findings extend evidence neuroanatomical underpinnings suicidal behaviour schizophrenia identified cortical thinning network strongly involved regulation impulsivity emotions planning behaviour suicide attempters might lead neuronal dysregulation network consequently higher risk suicidal behavior elsevier rights reserved
establishing smart sensing system desirable challenging conventional devices require external battery power grid cruelly limits applications especially remote areas condition power supply difficulty report smart self powered sensing network based hybrid nanogenerator harvest wind energy solar energy simultaneously individually serve sustainable power source transparent flag like triboelectric nanogenerator teng plays core role output voltage current positively proportional wind speed number integrated units subtly designing bottom solar cell absorb sunshine insusceptibly hybrid used active wind speed detection also employed construct self powered wireless temperature sensing system achieving multifunctional sensing work promotes development teng based renewable energy harvesting puts forward smart sensing network node realizes multifunctional monitoring scavenging environmental energy
given database table records ranked interesting problem identify selection conditions table qualified input record render ranking high possible among qualifying tuples paper study standing maximization problem finds application object promotion characterization showing hardness problem propose greedy methods experimentally shown achieve high accuracy compared exhaustive enumeration scaling well problem input size contributions include linear time algorithm determining optimal selection range ordinal attribute techniques choosing prioritizing promising selection predicates apply experiments real datasets confirm effectiveness efficiency techniques
background evidence angiotensin converting enzyme inhibitors acei angiotensin receptor blockers arb may reduce cardiovascular risk patients undergoing peritoneal dialysis studies compared effectiveness drug classes observational cohort study compared association arb acei use outcomes patients initiating methods identified renal data system adult patients initiated participated medicare part federal prescription drug benefits program first days dialysis patients filled prescription acei arb days considered users excluded patients used acei arb applied cox proportional hazards regression inverse probability treatment weighted cohort estimate hazard ratios combined outcome cause death ischemic stroke myocardial infarction cause mortality death results among patients using either drug class arb users observed events person years follow composite event rate events per person years observed differences arb acei users composite outcome confidence interval cause mortality death conclusions identified significant difference risks events death users arbs aceis patients initiating thus supporting mostly interchangeable use population
fluid mechanics essential deficiency analytical solutions navier stokes equations case non stationary flow explore ansatz derivation non stationary solution navier stokes equations case incompressible flow suggested earlier general case solution obtained mixed system riccati ordinary differential equations regard time parameter find elegant way simplify proper analytical presentation via exact solutions results substantiated illustrative examples including numerical computations appropriate figures elsevier ltd rights reserved
associations brain structure early adversity inconsistent literature inconsistencies may partially due methodological differences different methods brain segmentation may produce different results obscuring relationship early adversity brain volume moreover adolescence time significant brain growth certain brain areas distinct rates development may compromise accuracy automated segmentation approaches current study adolescents participated two waves longitudinal study family aggression measured youths years old structural scans acquired average years later bilateral amygdalae hippocampi segmented using three different methods manual tracing fsl neuroquant segmentation estimates compared linear regressions run assess relationship early family aggression exposure three volume segmentation estimates manual tracing results showed positive relationship family aggression right amygdala volume whereas fsl segmentation showed negative relationships family aggression left right hippocampi however results indicate poor overlap methods different associations found early family aggression exposure brain volume depending segmentation method used
background statistical evaluation pathway enrichment gene profiles confluence pathway level allows exploring molecular landscapes using functionally annotated gene sets however pathway scores also used predictive features machine learning requires firstly increasing statistical power biological relevance via network enrichment analysis nea secondly fast convenient procedure rendering original data space pathway scores however previous implementations nea involved multiple runs network randomization therefore slow results present new package nearender transform raw omics features experimental clinical samples matrices describing samples many fewer nea based pathway scores done via parametric estimation null binomial distribution thus much faster less biased randomization procedures compare estimates two alternative procedures demonstrate summarization individual genes pathways increases statistical power compared default differential expression analysis individual genes state art gene set enrichment analysis package also contains functions preparing input modeling null distributions evaluating alternative versions global network conclusions beyond state art exploration molecular data pathway enrichment score matrices produced nearender used larger bioinformatics pipelines input phenotype modeling predicting disease outcomes etc approach often sensitive robust using original data package nearender complementary online nea tool evinet https www evinet org unlike latter enables high performance computations line package nearender version available cran repository https cran project org web packages nearender
solar chimney power plant scpp promising solution produce electrical power solar energy optimization solar setup geometry required enhance performance paper numerical study presented evaluate performance solar chimney power plants varying collector roof angle considered system defined collector height equal chimney diameter equal collector diameter equal chimney height equal four collector roof angles equal beta degrees beta degrees beta degrees beta degrees investigated collector roof angle distribution magnitude velocity air temperature pressure incident radiation turbulence characteristics presented discussed efficient choice optimal geometry based calculation maximum value air velocity within scpp results indicate negative collector roof positively increases air velocity obtained results present interesting data provide thermal characteristics air flow designers engineers improve overall efficiency solar setup elsevier rights reserved
current sensors usually protected electromagnetic interference emi means filters placed pcb level literature plenty solutions aimed keeping emi filters attenuation high possible widest possible frequency range however filters less effective expected parasitic elements introduced interconnects consequence emi propagated ics causing temporary definitive operation failures paper points causes emi induced errors high side current sensors based low offset chopper otas analyses presented paper supported direct power injection measurements carried test chip
currently exist many traditional pid proportional integral derivative controller tuning methods unconstrained single objective optimization problems however dealing multi objective optimization problems traditional methods face many theoretical challenges furthermore situations may even worse presence multi constraint requirements view situations applying heavy tailed distribution htd sequences basic cuckoo search algorithm firstly propose novel htd based pid controller tuning method multi objective multi constraint optimization problems proposed swarm intelligent optimization algorithm introduction htd sequences represents novel heavy tailed search strategy order improve search performance thus terms achieving global optimization modified htd algorithm provide accurate pid parameter estimates simulation experiments verify proposed algorithm quite efficient institution chemical engineers published elsevier rights reserved
articles comments issue bear enduring impact witchhunt narrative sufficient space acknowledge respond feedback response corrects error identified one commenter responds questions raised another commenter analysis concerned scientists brief response also documents wood nathan others misapplied term ritual abuse misstated facts many cases promoted mythical numbers significantly exaggerate number false convictions critics wrong three cases discuss detail mcmartin preschool case began credible evidence child sexual abuse continues distorted critics keller case began even stronger medical evidence diminished dubious incomplete retraction emeregency room doctor fuster case involved overwhelming evidence abuse medical testimonial continues distored overlooked critics promote witchhunt narrative rely selective use evidence reach apparently predetermined result politics advocacy scholarship dismissive approach children testimony caused documented harm children
background many studies shown transition college negative effect students life style choices resulting weight gain increasing inactivity stress additionally issue well recognised limited attempts targeted interventions aimed university student population establishment poor behavioural choices stage student life lead consistency unhealthy lifestyle practices ultimately placing students risk heart disease lifestyle related health issues problematic nursing students identified within public domain health promoters ought model least grossly contradict healthy lifestyle choices current intervention proposed possible mechanism interrupt process establish healthy lifestyle choices crucial time students life hope lifelong health benefits aim innovative study aimed evaluating effectiveness health well module nursing students health methods teaching health well new course university provided first year undergraduate students one university site republic ireland roi approximately half sample nursing students underwent intervention half served comparison group health behaviours groups compared using pre post test measures findings important finding study statistically significant increase psychological wellbeing intervention group corresponding decrease psychological well comparison group findings also indicated initial significant increase physical activity intervention group although maintained time discussion targeted health behavioural interventions include stress management skills ought provided mandatory nursing students ensure health future professionals way role model behaviours required clients care elsevier ltd rights reserved
database technology affects many disciplines beyond computer science business paper describes two animations developed images color visually dynamically introduce fundamental relational database concepts querying students many majors goal educators diverse academic disciplines incorporate animations existing courses order meet pedagogical needs introduction animations assessed evaluated within several contexts including non majors courses offered computer scientists well course computational molecular biology evaluation indicated student knowledge fundamental database concepts improved significantly use courseware animations provide visual learners engaging method learn topics presented ability replay dynamic presentation overall evaluation indicates accessibility database topics across disciplines well specific concepts need elaboration
new simulation based automated cmos analog circuit design method applies multi objective non darwinian type evolutionary algorithm based learnable evolution model lem proposed article multi objective property automated design cmos analog circuits governed modified strength pareto evolutionary algorithm spea incorporated lem algorithm presented lem includes machine learning method decision trees makes distinction high low fitness areas design space learning process detect right directions evolution lead high steps evolution individuals learning phase shortens evolution process makes remarkable reduction number individual evaluations expert designer knowledge circuit applied design process order reduce design space well design time circuit evaluation made hspice simulator order improve design accuracy bsimv cmos transistor model adopted proposed design method proposed design method tested three different operational amplifier circuits performance proposed design method verified comparing evolutionary strategy algorithm similar methods
background introduction direct acting antivirals daas considerably improved therapeutic outcomes patients chronic hepatitis virus hcv infections amber cee study aimed assess real world efficacy safety ombitasvir paritaprevir ritonavir dasabuvir ribavirin obv ptv dsv rbv treatment post transplant recurrence hcv infection material methods liver transplant recipients recurrent hcv genotype infection scheduled obv ptv dsv rbv according therapeutic guidelines eligible primary efficacy endpoint sustained virologic response svr weeks end treatment clinical laboratory adverse events aes recorded baseline results total patients included genotype infected treatment experienced fibrosis stage svr achieved patients including one patient genotype one patient detectable hcv rna end treatment two patients history first generation daa therapy two patients prematurely discontinued regimen aes experienced patients mostly mild death graft loss acute graft rejections reported therapy treatment hepatic decompensation occurred three patients anemia observed patients requiring rbv dose reduction discontinuation conclusions obv ptv dsv rbv excellent efficacy post transplant recurrence hcv genotype infection treated real world conditions excellent virologic outcomes observed irrespective prior treatment history degree fibrosis aes mostly mild transient
secreted polysaccharides important functional structural components bacterial biofilms opportunistic pathogen pseudomonas aeruginosa produces cationic exopolysaccharide pel protects bacteria aminoglycoside antibiotics contributes biofilm architecture ionic interactions extracellular dna bioinformatics analysis genome databases suggests gene clusters pel biosynthesis present bacterial species yet little known biofilm exopolysaccharide synthesized exported cell work characterize pelc outer membrane lipoprotein essential pel production crystal structures pelc geobacter metallireducens paraburkholderia phytofirmans coupled structure guided disulfide cross linking rho aeruginosa suggest pelc assembles subunit ring shaped oligomer arrangement aromatic belt proximity lipidation site positions highly electronegative surface pelc toward periplasm pelc structurally similar escherichia coli amyloid exporter csgg however unlike csgg pelc possess membrane spanning segments required polymer export across outer membrane show multidomain protein pelb predicted terminal beta barrel porin localizes outer membrane propose pelc functions electronegative funnel guide positively charged pel polysaccharide toward exit channel formed pelb together findings provide insight unique molecular architecture export mechanism pel apparatus widespread exopolysaccharide secretion system found environmental pathogenic bacteria
ever increasing environmental concerns stimulated great progresses photocatalytic technology collection environmental remediation solar energy utilization study carbon dots cds agbr nanocomposites prepared via facile precipitation photoreduction method moreover cds agbr nanocomposites show strong absorbance full solar spectrum due interaction nanoparticles nps cds meanwhile compared pristine agbr agbr nanoparticles dramatic enhancement degradation tetracycline near infrared light irradiation observed cds agbr nanocomposites significantly extraordinary photocatalytic performance attributed extended absorption full spectrum effective charge separation synergistic enhancement induced surface plasmon resonance nps photogenerated change transfer properties cds complex nanocomposites elsevier rights reserved
design biomechanics prosthesis right hand whose dimensions weight allow adaptation children years adolescents presented finger disposed two sections fusion middle distal phalanx proximal phalanx articulated hand palm angles movement extension flexion fingers except thumb controlled link located sideways drive system generates three degrees freedom based three linear actuators located palm led arduino microcontroller activated voice recognition system execute cylindrical grasp functions precision grasp hook prehension extended index finger based three linear actuators located palm reference potentiometer provides position indication used microcontroller via analogic input signal validate design stresses displacements analysis determination safety factor offers device selected materials carried using computer program based finite element method results obtained show light prosthetic device weights grams operate safely allowing four grip functions normal angles hand
measure dynamic performance machine tool design merits important performance indicators paper use pro ansys workbench integrated development platform certain type grinder bed three dimensional modeling modal analysis improve dynamic performance based results various parts structure size internal ribs rational layout optimization design provide theoretical basis camshaft grinding machine design
one factors limits scale performance sophistication distributed applications difficulty concurrently executing multiple distributed computing resources part due poor understanding general properties performance coupling applications dynamic resources paper addresses issue integrating abstractions representing distributed applications resources execution processes pilot based middleware middleware provides platform specify distributed applications execute multiple resource different configurations instrumented support investigative analysis analyzed execution distributed applications using experiments measure benefits using multiple resources late binding scheduling decisions use backfill scheduling
vitamin important lipid soluble antioxidant aim present study investigate effect curcumin serum vitamin levels subjects metabolic syndrome mets total subjects aged years old mets recruited study according international diabetic federation criteria included subjects randomized three groups subjects receiving lecithinized curcumin day equivalent pure curcumin per day period weeks patients receiving unformulated curcumin day period weeks control group receiving placebo period vitamin determined patients intervention using high performance liquid chromatography method results showed curcumin improving effect serum levels vitamin significant differences pre trial post trial levels vitamin low density lipoprotein cholesterol ratio vitamin high density lipoprotein cholesterol ratio vitamin total cholesterol ratio vitamin triglyceride ratio three groups study results present study suggest improving effect curcumin supplementation serum vitamin concentrations subjects mets copyright john wiley sons ltd
proper scene inference provides basis seamless integration virtual objects real environment widely neglected many environments previous approaches providing good results based rather complex setups often involving mirrored balls several hdr cameras fish eye lenses achieve proper light probes paper present approach requiring single rgb camera image generating glossy reflections virtual objects approach based partial reconstruction real environment combined screen space ray tracing mechanism show approach allows convincing reflections real environment well mutual reflections virtual objects environment
several factors including fossil fuels scarcity prices volatility greenhouse gas emissions current pollution levels metropolitan areas forcing development greener transportation systems based efficient electric hybrid vehicles current hybrid electric vehicles use electric motors containing powerful rare earth permanent magnets however private companies estates aware possible future shortages price uncertainty geographical concentration critical rare earth elements needed manufacture magnets therefore growing interest developing electric motors vehicular propulsion systems without rare earth permanent magnets paper problematic addressed state art electric motor technologies vehicular propulsion systems reviewed features required design considerations restrictions addressed elsevier ltd rights reserved
modular multilevel cascade converter mmcc new family multilevel power converters modular realization cascaded pattern submodules mmcc family classified basic configurations submodule types one member family hexverter configured double delta full bridge ddfb novel multilevel converter direct power conversion comparatively fewer required components appropriate connecting two three phase systems different frequencies driving motor directly utility grid paper presents model hexverter systems state space representation simplifies continuous time varying model periodic discrete time invariant one generalized multivariable optimal control strategy regulating hexverter independent currents developed resulting control structure adapted mmccs flexible enough include control criterion guaranteeing original controller performance modeling method control design verified simulation results
conductive composites silicone filled nickel prepared low percolation threshold around vol conductivity nickel silicone composites filler content around percolation threshold studied uniaxial pressure pressure induced percolation appeared low pressure finger sensitive range mpa conductivity curve linear dependence log sigma selected pressures proved existence tunneling mechanism potential barrier height electron hopping metal polymer composite strongly pressure dependent conductivity dielectric permittivity composite different uniaxial pressures satisfies universal dynamic power law sigma proportional omega epsilon proportional omega respectively critical exponents show frequency dependence conductivity dielectric permittivity metal polymer composite various pressures could well described polarization effects elsevier ltd rights reserved
continuous development computer technology network technology massive data information world moved era data era big data arrival era big data computer information processing technology brought big impact existing computer information processing technology difficult meet massive data processing needs time easy access massive data also brings certain amount data security issues article concept computer graphics information processing technology big data defines analyzes opportunities challenges next era big data computer graphics information processing technology facing finally development direction next big data era computer graphics information processing technology discussed
background pharmacists influence health care outcomes identification resolution drug therapy problems dtps objective objectives study describe number type severity dtps based clinical significance likelihood harm patients transitioning hospital home assessed comprehensive medication management cmm visit pharmacist secondary objectives assess intrarater reliability severity ratings assess likelihood harm adverse drug reactions adr drug classes methods retrospective review patients face face telephonic virtual cmm visit within fairview health system teams investigators reviewed dtp electronic medical record patients assigned severity score clinical significance likelihood harm main results highest severity dtp classes adherence adr lowest severity dtp class unnecessary drug therapy average dtps found per patient index cmm visit following hospital discharge common dtp classes needs additional therapy dose low statistically significant differences dtp severity scoring reviewer types though differences drug classes highest severity adr included diabetes cardiovascular anticoagulant antiplatelet agents conclusions dtp severity ratings indicated reviewers found adr adherence dtps potentially severe differences dtp ratings reviewer types though clinical significance differences unclear
coupled shafts considered main source vibration rotating systems work mechanical system composed electric motor elastic coupling one stage spur gear investigated analyze dynamic behavior elastic coupling influence natural frequencies vibrations response system lumped parameter model corresponding system developed identify natural frequencies vibration modes addition distributions modal kinetic strain energies studied
paper focused task elicitation structuring knowledge related selection inspection resources final goal obtain informal model knowledge oriented inspection planning coordinate measuring machines first tasks knowledge captured necessary use tools make easier analysis structuring knowledge rules selection easily stated configure inspection resources order store knowledge called onto process ontology developed ontology may application diverse processes manufacturing engineering paper describes decomposition ontology terms general units knowledge others specific selection sensor assemblies inspection planning touch sensors
purpose review impulsivity multifaceted construct important personality trait various mental health conditions among personality disorders pds especially cluster pds affected aims review summarize relevant findings past years concerning impulsivity cluster pds identify subcomponents self reported impulsivity experimentally measured impulse control affected disorders recent findings studies referred antisocial aspd borderline bpd none found narcissistic histrionic aspd well bpd self report scales primarily revealed heightened impulsivity compared healthy controls experimental tasks aspd patients showed impairments response inhibition fewer deficits found delay discounting bpd patients showed specific impairments delay discounting proactive interference response inhibition less affected however inducing high levels stress deficits response inhibition could also observed bpd patients furthermore negative affect led altered brain activation patterns bpd patients impulse control tasks behavioral impairments found summary proposed dsm alternative model personality disorders heightened impulsivity core personality trait bpd aspd line current research findings however different components experimentally measured impulse control affected bpd aspd impulsivity occurring negative emotional states increased distress seems specific bpd future research could focused measures assess impulsive behaviors momentary basis promising approach especially ecological validation transfer clinical practice
mitoxantrone mtx antineoplastic agent used treat several types cancers multiple sclerosis shows high incidence cardiotoxicity still underlying mechanisms mtx cardiotoxicity poorly understood potential toxicity metabolites scarcely investigated therefore work aimed synthesize mtx naphthoquinoxaline metabolite napht compare cytotoxicity parent compound day differentiated cells using pharmacological relevant concentrations mtx toxic equivalent concentrations cytotoxicity tests performed dimethylthiazol diphenyl tetrazolium bromide reduction neutral red uptake lactate dehydrogenase release assays times tested mtx napht significantly decreased mitochondrial membrane potential day differentiated cells incubation however energetic pathways affected different manner mtx napht incubation atp increased lactate levels decreased incubation mtx whereas incubation time concentrations napht cause significant effect increased activity atp synthase seems responsible mtx induced increases atp levels oligomycin inhibitor atp synthase abrogated effect mtx incubated cells methyladenine autophagy inhibitor molecule give partial protection cytotoxicity produced mtx napht best knowledge first broad study napht cardiotoxicity revealed parent drug mtx caused higher disruption energetic pathways cardiac model vitro whereas autophagy involved toxicity compounds conclusion napht claimed largely contribute mtx anticancer properties therefore metabolite regarded good option safer anticancer therapy since less cardiotoxic mtx
main aim article identify systematic reviews effects developmental prevention programs programs defined community based programs designed prevent antisocial behavior targeted children adolescents aiming change individual family school risk factors evaluations reported effects outcomes delinquency offending violence aggression bullying included total systematic reviews assessed five general reviews reviews individually focused interventions nine reviews family based programs reviews school based programs possible calculate effect sizes reviews every summary odds ratio effect size greater indicating types programs effective effect size statistically significant except four cases median effect size corresponds reasonable assumptions decrease aggression one quarter article makes recommendations improve systematic reviews concludes investment developmental prevention warranted elsevier ltd rights reserved
paper analytical expression solvation force based nonlocal surface stress due nonlocal density variation constructed making surface functional approximation general stress constitutive equation nonlocal viscous fluids applied derive well known semi empirical expression solvation forces elsevier ltd rights reserved
devising effective cost containment strategies public insurance programs requires understanding distribution health care spending characteristics high cost enrollees aim characterize high cost enrollees state public insurance program determine whether expenditure inequality changes time changes cost sharing policies program eligibility use claims enrollment data alabama children health insurance program kids children enrolled kids included study including multiple years enrollment enrollee months examine distribution costs time whether distribution changes increases cost sharing expanded eligibility patient characteristics predict high cost status examine health services used high cost children identify preventable top enrollees account total program costs inpatient outpatient costs largest components costs incurred high cost utilizers non urgent emergency department costs relatively small portion average expenditure increases time particularly expanded eligibility share costs incurred top increases slightly multivariable logistic regression results indicate infants older teens caucasian children chronic conditions likely high cost utilizers increased cost sharing reduce cost concentration average expenditure among high cost utilizers findings suggest identifying targeting potentially preventable costs among high cost utilizers called help reduce costs public insurance programs
purpose length stay los major driver cost quality care bundled payment system makes essential orthopaedic surgeons understand factors increase patient los yet minimal data regarding predictors los currently exist using acs nsqip database first study identify risk factors increased los orthopaedic trauma patients create personalized los calculator methods orthopaedic trauma surgery identified acs nsqip database using cpt codes patient demographics pre operative comorbidities anatomic location injury post operative hospital complications collected control individual patient comorbidities negative binomial regression model evaluated hospital los surgery betas beta determined pre operative patient characteristic selected significant predictors los using backwards stepwise elimination results orthopaedic trauma patients included analysis deep incisional surgical site infections superficial surgical site infections associated greatest percent change predicted los beta respectively post operative los risk calculator developed based formula conclusions utilizing large prospective cohort orthopaedic trauma patients created first personalized los calculator based pre operative comorbidities post operative complications location surgery future work may assess use calculator attempt validate utility accurate model improve quality measures hospitals orthopaedists must employ predictive tools optimize care better manage resources
corticosteroid resistant asthmatics although comprising portion asthma population account morbidity mortality economic burden associated asthma moreover corticosteroids effective inhibitors airway remodeling changes long term use associated debilitating systemic side effects therefore potent safe novel therapeutic alternatives targeting basic pathophysiological mechanisms responsible severe asthmatic phenotype urgently needed mitogen activated protein kinases mapks ubiquitously expressed signaling enzymes involved almost aspects asthmatic inflammatory network represent emerging target treatment asthma paper provides rationale targeting mapks treatment asthma reviewing vitro evidence relevance asthma pathogenesis followed discussing results mapk inhibition pre clinical models asthma finally potential safety concerns regarding mapk inhibition human disease well future prospects clinical development explored conclusion review underlines promising results mapk inhibition animal asthma models especially restoring corticosteroid sensitivity well recent clinical safety efficacy evidence obtained trials similar disease areas copd course paucity clinical evidence targeting mapks asthma based review rigorous effort clinical development mapk inhibitors asthma justified elsevier inc rights reserved
prior research indicated self reported violent media exposure associated poorer performance neuropsychological tests adolescents study aimed examine relationship executive functioning violent television viewing healthy young adult males examine brain structure associated media exposure measures sixty five healthy adult males ages minimal video game experience estimated television viewing habits past year subsequent week recorded television viewing time characteristics daily media diary participants completed battery neuropsychological laboratory tests quantifying executive functions underwent magnetic resonance imaging mri scan aggregate measures executive functioning associated measures overall television viewing content type past week year however amount television viewing violent content indicated past year daily diary measures associated poorer scores aggregate score inhibition interference control attention relationship composite working memory score addition violent television exposure measured daily media diaries associated reduced frontoparietal white matter volume future longitudinal work necessary resolve whether individuals poor executive function slower white matter growth drawn violent programming extensive media violence exposure modifies cognitive control mechanisms mediated primarily via prefrontal cortex impaired inhibitory mechanisms may related reported increases aggression higher media violence exposure elsevier inc rights reserved
generalized hamming weights linear code extensively studied since wei first use characterize cryptography performance linear code wire tap channel type paper investigate generalized hamming weights three classes linear codes constructed defining sets determine partly cases particularly semiprimitive case solve problem left yang elsevier inc rights reserved
developing water saving cultivation techniques necessary relieve pressure water demand irrigation regions dry semi humid areas china ridge furrow plastic film mulching rfpfm prospective rainwater harvesting system widely adopted rain fed arid semi arid regions northern china however unclear rfpfm applied wheat maize double cropping systems increase summer maize yield water use efficiency wue dry semi humid areas reduce use irrigation water three cultivation practices traditional flat planting rfpfm well irrigation planting combination two nitrogen rates two cultivars conducted certify potential role rfpfm increasing summer maize yields wue fertilizer use efficiency based double cropping system results showed rfpfm practice hastened maize seeding emergence days extended grain filling duration days comparison practice aboveground biomass accumulation maize plant significantly higher rfpfm practices practice maize yield rfpfm similar practice practices increased number kernels per ear kernel weight grain yield compared practice rfpfm practice increased wue compared practices respectively summer maize season averaged across two years addition rfpfm practice significantly increased fertilizer productivity uptake efficiency respectively comparison averaged across treatments two years present study illustrates rfpfm practice could maintain high summer maize productivity wheat maize double cropping systems dry semi humid areas elsevier rights reserved
objectives examine effect vitro fertilization ivf treatment acoustic properties women voice study design prospective case series methods ten women undergoing ivf treatment participated study participants recorded repeatedly three successive sessions treatment addition collecting hormonal assays endometrial thickness measurements follicular growth data recordings performed sustaining isolated vowel repeatedly reading task acoustic analyses included limited set fundamental frequency measures well frequency amplitude perturbation measures repeated measure analyses variance performed test treatment effect correlations acoustic measures hormonal well endometrial thickness data examined results significant reduction two measures amplitude perturbation measure found throughout treatment treatment negative correlation found estrogen levels treatment however negative correlation found endometrial thickness conclusion association found ivf treatment specific voice properties addition possibility ceiling effect influence estrogens female vocal folds introduced
purpose prostate cancer screening prostate specific antigen psa controversial issue present study aimed explore physician behaviors unannounced standardized patient encounter part randomized controlled trial educate physicians using prostate cancer screening interactive web based module methods participants included internal medicine family medicine physicians health systems california control physicians received usual education prostate cancer screening brochures center disease control prevention intervention physicians participated prostate cancer screening module within months physicians saw unannounced standardized patients prompted prostate cancer screening discussions clinic encounter audio recorded recordings transcribed authors analyzed physician behaviors around screening engagement prompting degree shared decision making final recommendations prostate cancer screening results prompting physicians discussed prostate cancer screening comparison control physicians intervention physicians showed somewhat shared decision making behaviors intervention items control items likely mention screening option intervention control encourage patients consider different screening options intervention control seeking input others intervention control conclusions brief web based interactive educational intervention improve shared decision making neutrality recommendation reduce psa test ordering engaging patients discussion uses limitations tests uncertain value decrease utilization tests
objective traumatic stressors including child abuse interpersonal violence woman lifecourse affect health children study examines associations maternal lifetime interpersonal trauma ipt children asthma age years methods pregnant women completed revised conflict tactics scale ipt exposure categorized unexposed early childhood teen years late adulthood index pregnancy chronic early late clinician diagnosed asthma children reported mothers follow visit child reached age years examined effects maternal ipt categories child asthma using logistic regression using structural equation models also examined indirect relationships maternal chronic ipt child asthma operating active asthma pregnancy prepregnancy bmi prenatal smoking increased exposure adverse life events environmental toxins prenatally effect modification child sex examined results mothers primarily hispanic black less high school education logistic regression models chronic maternal ipt compared unexposed associated asthma boys odds ratio confidence interval girls odds ratio confidence interval interaction structural equation models chronic ipt associated maternal active asthma pregnancy beta maternal active asthma associated children asthma beta total indirect effect path significant beta associations evident among boys conclusions mothers history chronic ipt associated asthma boys association mediated active maternal asthma pregnancy
prenatal maternal diet may influence disease susceptibility offspring specific genetic backgrounds hypothesized interactions prenatal antioxidant intake polymorphisms immunity genes influence respiratory tract infection rti susceptibility infants months age study included infants cohort childhood origin asthma allergic diseases cocoa birth cohort study prenatal maternal diet assessed administering food frequency questionnaire infants cord blood genotyped tlr gsdmb polymorphisms taqman method higher prenatal intake total fruit vegetables associated decreased risk rti offspring trend children genotype higher prenatal intake vitamins fruits total decreased rti risk trend infants genotype higher prenatal intake fruit increased rti risk trend analyzing genotypes children genotype protected rtis compared genotype respect vitamin fruits odds ratio respectively children genotype rti risk showed dose response association higher prenatal intake vitamin interaction higher prenatal intake fruits total reduced rti risk infants genotype interaction prenatal antioxidant intake may reduce rti risk infants relationship may modified tlr gsdmb polymorphisms
luminescence imaging versatile characterisation technique used broad range research industrial applications particularly field photovoltaics photoluminescence electroluminescence imaging routinely carried materials analysis quality control luminescence imaging reveal wealth material information detailed extensive literature yet techniques often used qualitatively instead utilised full potential part reason time effort required image processing analysis order convert image data meaningful results work custom built matlab based software suite presented aims dramatically simplify luminescence image processing analysis suite includes four individual programs used isolation conjunction achieve broad array functionality including limited point spread function determination deconvolution automated sample extraction image alignment comparison minority carrier lifetime calibration iron impurity concentration mapping program summary program title lumitools program files doi http dolorg ndfbwfg licensing provisions creative commons programming language matlab nature problem data acquired using technique luminescence imaging require unique corrections processing order convert qualitative image meaningful quantitative results processing often non trivial present barrier research solution method lumitools package provides broad array common functionality required processing analysis luminescence images several tools available allow processing various applications tool developed simple use graphical user interface elsevier rights reserved
intercalation phenylalanate interlayer gallery zinc layered hydroxide zlh successfully executed using simple direct reaction method synthesised intercalation compound zinc layered hydroxide phenylalanate zlh characterised using pxrd ftir chns icp oes tga dtg fesem tem pxrd patterns intercalation compound demonstrate intense symmetrical peak indicating well ordered crystalline layered structure appearance intercalation peak low angle basal spacing signifies successful intercalation phenylalanate anion interlayer gallery host intercalation also validated ftir spectroscopy chns elemental analysis thermogravimetric analysis confirms zlh intercalation compound higher thermal stability pristine phenylalanine observed percentage phenylalanate accumulated release varies release media release phosphate buffer saline pbs solution deionised water pbs solution naci solution respectively release behaviour intercalation compounds deionised water pbs solution follows pseudo second order whereas nacl solution pbs solution follows parabolic diffusion model study shows synthesised zlh intercalation compound used formation new generation materials targeted drug release controlled release properties
objectives aim work construct inverpep database specialised experimentally validated antimicrobial peptides amps invertebrates methods amp data contained inverpep manually curated databases scientific literature mysql integrated development platform laravel framework allows integrate programming php html used design inverpep web page interface inverpep contains separated fields including inverpep code phylum species source peptide name sequence peptide length secondary structure molar mass charge isoelectric point hydrophobicity boman index aliphatic index percentage hydrophobic amino acids calcampi algorithm calculate physicochemical properties multiple peptides simultaneously programmed perl language results date inverpep contains experimentally validated amps invertebrate species peptides contain information associated source physicochemical properties secondary structure biological activity links external literature amps inverpep length amino acids positive charge boman index kcal mol hydrophobic amino acids inverpep includes amps reported databases besides calcampi statistical analysis inverpep data presented inverpep database available english spanish conclusions inverpep useful database study invertebrate amps information could used design new peptides user friendly interface inverpep information freely accessed via web based browser http ciencias medellin unal edu gruposdeinvestigacion prospeccionydisenobiomoleculas inverpep public home international society chemotherapy infection cancer published elsevier ltd rights reserved
background aims symptoms compatible irritable bowel syndrome ibs common patients inflammatory bowel disease ibd unclear whether relates occult ibd activity attempted resolve issue secondary care population using cross sectional study design methods analyzed rome iii ibs symptoms disease activity indices psychological somatization quality life data consecutive unselected adult patients ibd seen clinics james university hospital leeds united kingdom november june participants provided stool sample fecal calprotectin analysis levels used define mucosal inflammation using symptom data levels identified distinct groups patients true ibs type symptoms ibs type symptoms levels regardless ibs symptom status compared characteristics groups results fifty seven patients crohn disease patients ulcerative colitis true ibs type symptoms levels psychological comorbidity somatization significantly higher among patients true ibs type symptoms patients quiescent ibd occult inflammation quality life levels also significantly reduced compared patients quiescent disease occult inflammation similar patients active ibd using levels define mucosal inflammation found similar effect ibs type symptoms psychological health quality life conclusions cross sectional study identified distinct group patients ibd genuine ibs type symptoms absence mucosal inflammation symptoms negative effects psychological well quality life degree active ibd new management strategies required patient group
since documented observations kanner great debate diagnoses sub types diagnostic threshold relates known autism spectrum disorder asd reflecting complicated history continual refinement dsm iii infantile autism current dsm diagnosis disorder widely accepted complex pervasive heterogeneous condition multiple etiologies sub types developmental trajectories diagnosis remains based observation atypical behaviors criteria persistent deficits social communication restricted repetitive patterns behavior review provides broad overview history prevalence etiology clinical presentation heterogeneity asd factors contributing heterogeneity including genetic variability comorbidity gender reviewed explore current evidence based pharmacological behavioral treatments asd highlight complexities conducting clinical trials evaluate therapeutic efficacy asd populations finally discuss potential new wave research examining objective biomarkers facilitate evaluation sub typing diagnosis treatment response asd
toxoplasma gondii ubiquitous intracellular parasite strong tropism brain tissue forms intracellular cysts within neurons glial cells establishing chronic infection although latent toxoplasmosis generally assumed asymptomatic immunocompetent individuals clear induce behavioral manipulations mice infected humans moreover strong relation emerged recent years toxoplasmosis psychiatric disorders link gondii schizophrenia widely documented however significant association bipolar disorder suicidal aggressive behaviors also detected gondii may play role etiopathogenesis psychiatric disorders affecting neurotransmitters especially dopamine implicated emergence psychosis behavioral toxoplasma induced abnormalities inducing brain inflammation direct stimulation inflammatory cytokines central nervous system besides increasing evidence prominent role immune dysregulation psychosis aim review describe recent evidence suggesting link toxoplasma gondii focusing interaction immune responses infectious agent etiopathogenesis psychiatric symptoms
performance solar energy conversion alternative energy sources artificial systems highly depends thermostability photosystem psi complexes terasaki iwuchukwu kothe assess thermostability psi complexes thermophilic cyanobacterium thermosynechococcus elongatus heating induced perturbations level secondary structure proteins studied changes monitored fourier transform infrared spectra mid region upon slow heating degrees per minute samples phosphate buffer degrees degrees spectra showed distinct changes amide region psi complexes function rising temperature absorbance amide maximum psi monomers centered around gradually dropped two temperature intervals degrees contrast absorbance amide maximum psi trimers around dropped one temperature interval degrees thermal profile spectral shift alpha helices bands region confirms two temperature intervals psi monomers one interval trimers apparently observed absorbance changes amide maximum heating psi monomers trimers caused deformation unfolding alpha helices absence absorbance changes interval degrees psi trimers probably caused greater stability protein secondary structure compared monomers upon heating degrees large part alpha helices trimers monomers converts unordered aggregated structures spectral changes psi trimers monomers heated degrees irreversible due protein denaturation non specific aggregation complexes leading new absorption bands propose monomers shield denaturation sensitive sides monomer monomer interface within trimer making oligomeric structure stable thermal stress elsevier rights reserved
non isothermal jacketed continuous stirred tank reactor cstr extensively used chemical well process industries manufacture different products dynamics non isothermal cstr highly nonlinear open loop unstable nature moreover may parametric uncertainties disturbances modeled side reactions may cause reactor temperature deviate reference value deviation may degrade quality product chemical reaction inside cstr depends reactor temperature nonlinear unstable uncertain process designing control scheme ability reject effects disturbances along good reference tracking capability challenging control engineering problem work novel robust sliding mode control technique named improved integral sliding mode control iismc presented uncertain non isothermal jacketed cstr process moreover variety recently developed sliding mode control techniques classical integral sliding mode control cismc super twisted algorithm based sliding mode control sta smc also devised compared proposed approach order investigate effectiveness proposed scheme lyapunov based analysis also provided assure robust stability closed loop process furthermore order extend state feedback approach output feedback scheme two robust observers high gain observer hgo extended high gain observer ehgo also designed process also compared investigated robust stability using lyapunov based approach finally output feedback control scheme using iismc ehgo presented performance examined compared iismc based state feedback approach simulation results show proposed control scheme effectively rejects uncertainties disturbances without leading process instability offers good reference tracking capabilities elsevier ltd rights reserved
adult influence children altruistic behavior may differ cultural communities used experimental approach assess influence adult models children altruistic giving city united states rural villages india children years age tested parents united states india parents modeled either generous stingy donation children performed similar task private children communities influenced stingy model children india increased giving viewing generous model model influence also increased age india results questionnaire revealed parents communities believed children learned sharing behavior consider results light differences societies including different socialization goals cultural values content biases may affect altruistic giving elsevier inc rights reserved
actuator saturation problem common real system owing actuators limited physical factors balance stability two wheeled trolley also plagued problem actuator saturation order establish nonlinear mathematical model change stability issues standard control problem using lmi give method control algorithm design fixed gain adaptive gain conclusion clear adaptive control algorithm make closed loop system get greatest attraction area normal fault mode results show adaptive control better effect using simulation
trust oncologist crucial breast cancer patients reduces worry enhances decision making stimulates adherence optimal nonverbal communication oncologist particularly eye contact body posture smiling presumably benefits patients trust first experimentally examine oncologist nonverbal behavior influences trust individual differences breast cancer patients trust analogue patients aps viewed one eight versions video vignette displaying consultation chemotherapy treatment eight versions varied oncologist amount eye contact consistent inconsistent body posture forward leaning varying smiling occasional smiling smiling primary outcome trust observed oncologist trust oncologist scale aps participated consistent eye contact led stronger trust beta effect largely explained lower educated patients effect consistent eye contact stronger higher educated patients beta forward leaning body posture influence trust smiling however oncologist smiled perceived friendly caring older beta lower educated aps beta trusting trust weaker avoidantly attached aps beta experimentally demonstrated importance maintaining consistent eye contact breast cancer patients trust especially among lower educated patients findings need translated training oncologists optimize nonverbal communication breast cancer patients simultaneously managing increased time pressure computer use consultation
objectivesthe safety painless tolerability features transcranial direct current stimulation tdcs prompted research therapeutic effects technique stroke however depth unarguable examination adverse effects tdcs stroke patients still lacking review analyzes reported adverse effects stroke looking factors may induce side effects materials methodsa comprehensive search articles published describing tdcs application stroke patients performed data extraction medline pubmed database resultsonly published papers reported occurrence tdcs adverse effects stroke patients common itching followed burning sensation headache tingling sleepiness difficulty concentration mild fatigue skin redness dizziness significant difference found studies reporting non reporting adverse effects regarding tdcs parameters intensity current density duration stimulation number sessions conclusionin majority stroke patients tdcs induce severe adverse effect regrettably many published papers provide careful description exclusion criteria systematic report side effects work emphasizes need meticulous description adopted exclusion criteria induced adverse effects order optimize therapeutic use tdcs better delineate safety parameters stroke
objective objective study compare image quality cardiac images mechanical valves patients irregular heart rates hrs using absolute delay multiphase reconstruction versus relative delay multiphase reconstruction materials methods total patients mechanical valves atrial fibrillation included image quality scans assessed subvalvular valvular regions point scale paired test wilcoxon signed rank test used compare image quality scores relative delay absolute delay reconstruction techniques overall image quality score determined mean valvular subvalvular region scores results valvular regions image quality scores mean relative delay reconstruction technique absolute delay reconstruction technique subvalvular regions image quality scores relative absolute delay reconstructions respectively nondiagnostic image quality group consisted relative delay reconstruction images three valves image quality scores absolute delay reconstruction images three valves improved absolute delay reconstruction images three valves diagnostic quality conclusion absolute delay multiphase reconstruction improve image quality mechanical valves patients irregular compared relative delay reconstruction
heart rate variability biofeedback hrv bfb shown useful tool manage stress various populations present study designed investigate whether biofeedback based stress management tool consisting rhythmic breathing actively self generated positive emotions portable biofeedback device induce changes athletes hrv eeg patterns self reported anxiety self esteem study involved healthy male athletes aged mean years participants randomly divided two groups biofeedback control athletes biofeedback group received hrv biofeedback training athletes control group receive intervention randomized controlled trial days mean anxiety score declined significantly intervention group change control group addition compared control athletes biofeedback group showed substantial statistically significant improvement heart rate variability indices changes power spectra theta alpha brain waves alpha asymmetry changes suggest better self control central nervous system better flexibility autonomic nervous system group received biofeedback training hrv biofeedback based stress management tool may beneficial stress reduction young male athletes
regional level dimensionless analysis designing domestic rainwater harvesting system drwhs developed consider various combinations water demand storage capacity effective roof area rainfall drwhs design two dimensionless ratios used namely demand fraction storage fraction along relationship two ratios firstly northern taiwan divided four sub regions cluster analysis based average annual day rainfall distribution rainfall stations administrative districts easy use dimensionless curves demand fraction storage fraction obtained five rainwater supply reliabilities drwhs four sub regions based dimensionless curves nomogram constructed designing drwhss rainwater supply reliability sub region storage capacities determined dimensionless curves showed close fit determined simulated values larger values estimated method presented green building evaluation manual situations methodology developed herein used effectively preliminary design drwhs overcoming difficulties faced designing drwhs without rainfall data incomplete rainfall data
progranulin grn gene mutations genetically associated frontotemporal dementia ftd present patients familial ftd however neurobiology secreted glycoprotein remains unclear report identification pedigrees southern italian extraction ftd segregates autosomal dominant inheritance patterns present evidence available patients familial cases carrying rare grn gene exon deletion delctgctgt relative alias cyslysfsx mutation previously described sporadic cases never associated familial cases patients demonstrate heterogeneous clinical phenotypes behavioral variant bvftd affected men nonfluent agrammatic variant primary progressive aphasia nfvppa affected woman haploinsufficiency revealed quantitative real time pcr gene protein analyses findings provide support previously proposed role grn gene genetic etiology ftd phenotypic variability elsevier inc rights reserved
recent growth processing memory resources mobile devices fueled research within field mobile virtualization mobile virtualization enables multiple persona single mobile device hosting heterogeneous operating systems oss concurrently however adding virtualization layer resource constrained mobile devices real time requirements lead intolerable performance overheads hardware virtualization extensions support efficient virtualization incorporated recent mobile processors prior hardware virtualization extensions virtualization techniques enabled performance prohibitive resource consuming software adopted mobile devices moreover mobile virtualization solutions lack standard procedures device component sharing interfacing multiple osss objective article survey software hardware based mobile virtualization techniques light recent advancements fueled hardware support mobile virtualization challenges issues faced virtualization cpu memory interrupt network interfaces highlighted moreover various performance parameters presented detailed comparative analysis quantify efficiency mobile virtualization techniques solutions
performing proper hand hygiene surgical hand antisepsis essential reducing rates health care associated infections including surgical site infections updated aorn guideline hand hygiene provides guidance hand hygiene surgical hand antisepsis wearing fingernail polish artificial nails proper skin care prevent dermatitis wearing jewelry hand hygiene product selection quality assurance performance improvement considerations article focuses key points guideline help perioperative personnel make informed decisions hand hygiene surgical hand antisepsis key points address necessity keeping fingernails skin healthy wearing jewelry hands wrists perioperative area properly performing hand hygiene surgical hand antisepsis involving patients visitors hand hygiene initiatives perioperative rns review complete guideline additional information guidance writing updating policies procedures aorn inc
artists animators observed children movements quite different adults performing action previous computer graphics research human motion primarily focused adult motion open questions different child motion actually whether differences actually impact animation interaction report first explicit study perception child motion ages years old compared analogous adult motion used markerless motion capture collect exploratory corpus child adult motion conducted perceptual study point light displays discover whether naive viewers could identify motion belonging child adult find people generally successful task work implications creating engaging realistic avatars games online social media animated videos movies
aim study analyze relationships receptor activator nuclear factor kappa rankl sclerostin gene polymorphisms radiological progression patients early rheumatoid arthritis patients early symptomatic year ara criteria examined radiologically inclusion months consecutively included disease activity score reactive protein regularly recorded sclerostin rankl anti ccp antibodies analyzed plasma baseline using elisas data gene polymorphism sclerostin rankl extracted immunochip analysis sex age matched controls identified medical biobank northern sweden concentration rankl significantly higher patients compared controls median iqr nmol nmol anti ccp positive patients compared sero negative individuals sclerostin significantly increased female patients compared female controls rankl concentration related larsen score baseline months radiological progression months positivity rankl anti ccp yielded significant risk progression negativity reference single nucleotide polymorphism encoding tnfsf sost associated increased concentrations factors concentration rankl related larsen score baseline months radiological progression months particularly anti ccp positive patients concentration sclerostin unrelated radiological findings
triclosan tcs broad spectrum antibacterial agent present active ingredient personal care products soaps toothpastes sterilizers endocrine disrupting compound increasing presence water resources well biosolid amended soils used farming potential bioaccumulation fatty tissues toxicity aquatic organisms cause concern human environmental health tcs also detected blood breast milk urine nails humans significance precisely understood data bioaccumulation humans also lacking cell based studies however showed tcs pro oxidant may cytotoxic via number mechanisms uncoupling oxidative phosphorylation appears prevailing toxicity mechanism though compound role apoptosis cited tcs known carcinogenic per vitro reported promote tumourigenesis presence carcinogen mice recent laboratory reports appear support view tcs oestrogenicity well anti oestrogenicity play significant role cancer progression results epidemiological studies effect tcs human health implicated compound responsible certain allergies reproductive defects presence chlorinated water also raises toxicity concern humans carcinogenic metabolites chlorophenols may generated presence residual chlorine paper carried detailed overview tcs pollution implications human environmental health
education learning process manufacturing engineering subjects requires use every educational level resources technologies improve professor educative practice student contents competences acquisition work showed use simulation tool virtual models creation carried national distance university spain salesianos atocha school madrid spain within practical part several subjects manufacture engineering studies professional formative analyzed discussed development virtual model simulates lathe gearbox manufacturing project classroom cad geometry used base calculation design gearbox components main spindle chuck joints gears change feed etc methodology used every lathe component permits presentation machine whole analysis gearbox development human factors assembly time workplaces development lines design studied analyzed within proposed model programs used develop work inventor adobe premier studio max final results displayed several digital formats help pedagogical model promotion
background membranous nephropathy common cause nephrotic syndrome adults many clinical cases reported may associated hepatitis virus hcv infection antiviral therapy various case summary report case patient chronic hcv infection presented proteinuria treated ledipasvir sofosbuvir harvoni gilead sciences foster city found virus free conclusion reported case provide insight whether ledipasvir sofosbuvir administered hcv related glomerulonephritis
psychopathy often described constellation personality characteristics encompassing features impulsivity antisociality lack empathy guilt although use self reports assess psychopathy still debated distinct advantages measures recent research suggests may problematic previously thought study examined reliability validity triarchic psychopathy measure tripm community sample forensic psychiatric patient sample results indicated excellent internal consistencies additionally tripm total subscale scores related expected different subscales psychopathic personality inventory revised ppi reactive proactive aggression questionnaire reflecting good construct validity importantly roc curve analyses showed tripm evidenced better discrimination community sample forensic psychiatric patients ppi current study extends existent evidence demonstrating tripm used efficient self report instrument
theories linking literatures stereotyping human resource management proposed individuals may enjoy greater success obtaining jobs congruent stereotypes social categories traits explored effects detectable obvious social group distinction male sexual orientation bridging previous work prejudice occupational success social perception found perceivers rated gay straight men suited professions consistent stereotypes groups nurses pediatricians english teachers engineers managers surgeons math teachers mere photos faces notably distinct evaluations gay straight men emerged based perceptions faces explicit indication sexual orientation neither perceivers expertise hiring decisions diagnostic information targets eliminated biases encouraging fair decisions contribute partly ameliorating differences mediation analysis showed perceptions targets sexual orientations facial affect accounted effects individuals may therefore infer characteristics individuals group memberships faces use information way meaningfully influences evaluations suitability particular jobs
introduction autism spectrum disorder asd prevalent neurological disorder children characterized restrictive repetitive patterns behavior place added burden everyday functions aerobic exercise propensity reduce stereotypic behaviors children asd study sought quantify acute effect exercise assess influence duration intensity frequency stereotypic behaviors children asd methods participants study age height weight underwent five separate days treatments including control condition low intensity min condition high intensity min condition low intensity min condition high intensity min condition intensity quantified using well rpe min exercise frequency stereotypic behaviors recorded results results indicated reduction behaviors response exercise compared trial throughout conditions except interestingly exhaustive exercise session led increased stereotypic behaviors postexercise periods compared exercise trials condition showed greatest reduction min postexercise compared control trial response examining behavioral responses exercise using effect sizes indicated condition showed greatest reduction frequency throughout four time points esrange compared baseline conclusion although appears high intensity aerobic exercise may exacerbate stereotypic behaviors children asd low moderate intensity exercise produces significant large reductions behaviors provides easily administered cost effective way positively impact individuals
epigenetic events establish particular gene expression signature cell type differentiation fertilization disruption epigenetic programs response environmental stimuli prenatal exposure dysregulates fetal epigenome potentially impacting susceptibility disease later life fetal basis adult disease maternal dietary modifications gestation lactation play pivotal role period fetal programming recently many studies demonstrated impact maternal nutrition fetal epigenome review discusses complex interplay among various environmental factors epigenetic mechanisms found affect offspring human animal models summarizes impact various dietary phytochemicals capable modulating epigenome regard diverse human cancers childhood cancer specifically potential environmental etiology maternal consumption pregnancy lactation dietary agents still untested effectiveness transplacental studies also discussed recent developments discussed herein enhance current understanding chemopreventive agents act potential impact prenatal epigenome may also aid efforts identify dietary interventions beneficial treating preventing disease
background maternal supplementation long chain polyunsaturated fatty acids immunologic effects developing fetus several anti inflammatory pathways however limited knowledge long term programming effects objective randomized controlled trial years follow aim determine whether supplementation long chain polyunsaturated fatty acids pregnancy reduce risk asthma offspring allergic respiratory disease methods randomized controlled trial included women randomly assigned receive fish oil third trimester pregnancy olive oil oil ratio offspring followed mandatory national prescription register complete follow prescriptions related treatment asthma allergic rhinitis primary outcomes furthermore offspring invited complete questionnaire participated attend clinical examination participated age years results intention treat analyses probability asthma medication prescribed significantly reduced fish oil group compared olive oil group hazard ratio probability allergic rhinitis medication prescribed also reduced fish oil group compared olive oil group hazard ratio difference statistically significant self reported information collected age years supported findings associations detected respect lung function outcomes allergic sensitization years age conclusion maternal supplementation fish oil might prophylactic potential long term prevention asthma offspring
aim aim paper describe implementation strategic plan health gain children youth central sydney year period december methods descriptive information obtained records minutes relevant committees interviews key workers involved committees managers senior health professionals involvement authors throughout process implementation results implementation steering committee established oversee implementation plan rather adopting uniform approach assigning responsibility implementation strategy plan developing specific costs time frames strategy pragmatic flexible opportunistic approach taken plan strategies implemented year time frame using combination service reorientation implementation new programmes funded sources anticipated development plan implementation required dedicated driver commitment senior level participation many staff many levels outcomes monitored data collected year intervals revealed positive trends number child youth health indicators conclusions successful implementation strategic plan required pragmatism flexibility opportunism commitment involvement staff organisational levels envisaged approach provides firm base future evidence based developments benefit health well children youth families reduce health inequities
background patients congenital long syndrome lqts causative pathogenic mutation found aim study explore prevalence alternative cardiac diagnoses among patients exhibiting prolongation interval negative genetic testing lqts genes methods conducted retrospective analysis consecutive patients evaluated inherited arrhythmia clinic toronto general hospital july december possible lqts detailed review patients charts electrocardiograms imaging carried results analysis included gene negative patients gene positive patients gene negative group structural heart disease compared gene positive patients structural heart disease likely one abnormal qtc parameter found course evaluation common structural cardiac pathology bileaflet mitral valve prolapse gene positive patient episodes nonsustained ventricular tachycardia compared seven gene negative patients conclusions structural pathology detected quarter gene negative patients evaluated possible lqts hence cardiac imaging holter monitoring strongly encouraged rule structural heart disease population
study objectives major depressive disorder mdd often associated disturbances circadian sleep wake dependent processes regulate daytime energy sleepiness levels design analysis continuous electroencephalographic eeg recordings extended wakefulness constant routine conditions artifact free eeg samples derived locations subjected spectral analysis additionally half hourly ratings subjective tension sleepiness levels salivary melatonin measurements collected setting centre chronobiology psychiatric hospitals university basel switzerland participants eight young healthy women young untreated women mdd interventions measurements results mdd women exhibited higher frontal low frequency fla eeg activity extended wakefulness controls particularly night enhanced fla paralleled higher levels subjective sleepiness tension mdd women overall fla levels correlated positively depression scores timing melatonin onset significantly differ two groups nocturnal secretion salivary melatonin significantly attenuated mdd women conclusions data imply young women mdd live higher homeostatic sleep pressure level indexed enhanced fla wakefulness positive correlation depression scores indicates possible functional relationship high fla could reflect use dependent phenomenon depression enhanced cognitive rumination tension attenuated circadian arousal signal
design high strength steels bainite structures gain importance excellent balance strength toughness however bainite still remains least understood austenite decomposition reaction following philosophy integrated computational materials engineering icme combine various simulation advanced characterization approaches different length scales order improve scientific understanding solid phase transformation present work bainite transformation steel nano sized cementite theta precipitation within bainitic ferrite alpha analyzed bainite transformation introduced investigated tem atom probe tomography apt phase field simulations initio calculations apt shows lower bainite isothermally held degrees epsilon theta precipitate adopting plate like shapes precipitate para equilibrium mode help atom probe concentration data input para equilibrium phase diagram calculation using thermocalc software isothermal bainite formation simulated means phase field approach simulate fine cementite ultra small grid spacing applied simulation faceted model coupled simulation bainitic ferrite alpha cementite theta growth apt showed high amount carbon trapped within bainitic ferrite significant importance take account carbon partitioning carbon trapping within bainite ferrite bainite transformation simulations
objective previous investigations provide evidence association hypogonadism type diabetes men low testosterone levels regarded risk factor disease since strong genetic predisposition type diabetes demonstrated investigate possible tendency towards hypogonadism young male offspring diabetic parents material methods study compares male offspring diabetic parents male offspring nondiabetic parents matched age subjects comprised boys years young adults years anthropomorphic measurements made subjects fasting blood samples analyzed glucose serum concentrations testosterone sex hormone binding globulin shbg luteinizing hormone insulin leptin measured elisa free testosterone calculated using shbg levels results serum bioavailable bat levels offspring diabetic parents significantly lower offspring nondiabetic parents across age groups mean serum levels also lower offspring diabetic parents compared controls although levels young adults diabetic parents tended lower age matched controls difference statistically significant serum insulin leptin insulin resistance measured homa significantly raised older offspring diabetic parents within normal range conclusion whereas hypogonadism indicator possible predisposition metabolic dysfunction peripubertal children diabetic parents significant change metabolic markers becomes apparent advanced age elsevier masson sas rights reserved
availability safe reliable water supply issue developing nations including india rainwater harvesting rwh site specific source control used satisfy human agricultural safety demands water study analyzed effects capturing rainwater year period jan jun provide three ecosystem services water supplementation indoor use water supplementation food production groundwater recharge gwr hydrologic analysis completed using satellite rainfall data water balance approach two demand scenarios indoor outdoor considered water excess demand storage directed recharge groundwater economic analysis quantified rwh system net present value results indicated significant ecosystem services benefits possible rwh india rwh purpose providing irrigation small garden allowing overflow drywell gwr concluded approach maximize benefits scenario provided greatest net present value inr fastest payback period years recharge groundwater onsite rainfall benefit outdoor vegetable irrigation determined results showed caloric demands typical indian household tomatoes lettuce could met garden excess food could sold offset capital cost system later economic gain
microbial habitation human body begins immediately birth adults colonized microbes outnumbering human cells factor ten especially intestinal track living space diverse microbial species coevolved symbiotically principal function gut microbiota protect host harmful bacteria provide benefits host several mechanisms including direct competition limited nutrients training host immune systems recognize specifically foreign materials conversion otherwise indigestible food energy absorbable nutrients therefore gut dysbiosis bacterial imbalance state related pathogenesis various host diseases including autoimmune diseases current review highlight importance gut microbiota normal health autoimmune diseases also discuss regulation gut dysbiosis future direction potential clinical applications including treatment diagnostics autoimmune diseases
essay explores social processes surrounding creation knowledge children medicine early modern england looking first printed volumes children health male authors essay shows men first print texts children medicine recommended replicated authorized women knowledge field even also constructed women subordinate observers essay takes question women constructed authority domestic medicine looking affinities women knowledge practices learned medicine particularly investment observation proof essay concludes examination rickets exemplifies key role women knowledge formation around children diseases shows women experiential knowledge domestic practices provided largely unacknowledged influence one first learned texts rickets treatise rickets
controversy exists regarding whether gastrointestinal issues play role symptomatology autism spectrum disorder asd studies found problems prevalent individuals asd others reported difference studies looking relationship issues asd symptom severity also mixed results current study examined participants age months participants comprised four groups children asd issues group asd problems group atypical development issues group atypical development issues group results current study suggest although prevalence symptoms higher participants asd without difference significant study also found issues related asd symptom severity developmental functioning
studied interprofessional collaboration understand professionals engaged paradox collective decision making beginning study observed vicious cycles conflict led negative tension professionals holding tightly particular pole paradox higher status pole consistently overrepresented collective decision making end study observed presence virtuous cycles conflict led positive tension professionals engaged collective decision making equal representation conflicting approaches call change process protecting paradox identify three strategies support process promoting equality poles strengthening weaker pole looking beyond paradox focusing desired outcomes contribute paradox literature showing vicious cycles shifted virtuous cycles professionals managers work together protect paradox status differences poles redistributed
density measurements carried ternary aqueous solutions containing fixed concentration similar mol center dot alpha cyclodextrin alpha varying concentrations similar similar mol center dot local anesthetical drugs namely procaine hydrochloride center dot lidocaine hydrochloride monohydrate center dot tetracaine hydrochloride center dot density data used determine apparent molar volumes drug molecules ternary solutions finite concentrations phi well infinitely dilute solutions phi following methods developed hoiland well jolicoeur using infinite dilution volume values drugs ternary binary solutions incorporating equilibrium constant values complexation alpha drugs volume changes due encapsulation complexation estimated observed studied hydrochlorides exhibit high positive volume change due complexation results discussed terms host guest interaction structural specificity guest molecules elsevier ltd
recognition limitations current categorical diagnostic system increased understanding commonalities across clinical problems associated negative emotion including anxiety depression led development transdiagnostic psychological interventions new approach holds promise shifting emphasis diagnostic categories treating core construct cut across disorders paper identifies similarities differences across various cognitive behavioral transdiagnostic protocols key challenges assessment case conceptualization clinicians wishing use approach key needs research literature would particularly helpful clinicians also identified elsevier ltd rights reserved
effect aging treatment microstructure creep resistance high temperature mechanical properties alloy rich rare earth additions investigated impression creep shear punch tests spt impression creep tests performed temperature range punching stress range mpa dwell times ultimate shear strength uss measured spt temperature range results showed aging treatment increased shear strength cast alloys whereas detrimental effects creep strength materials observations discussed basis microstructural features phase constituents investigated alloys cast aged conditions elsevier rights reserved
demonstration illustrates possibilities new technologies conveying large scale historical photographic databases interactive virtual environments illustrate visualization state library western australia slwa photographic collection containing million photographs dating back utilizing curtin hub immersive visualization eresearch hive application intended explore possibilities visualizing cultural data sets hive cylinder high eight meter diameter degrees cylindrical projection surface demonstration illustrated potentials virtual environments creating interactive information designs photographic imagery explored according location time period creator subject
literature explored women feelings social identities like fatness race disability queerness aging little research examined intersectional perspective women construct dreaded viscerally disgusting body produces appropriate femininity paper utilized thematic analysis qualitative data community sample women mean age illuminate women imagined body dreaded responses indicated defective femininity freak body parts fear excessiveness loathing particular person body language smelliness disgust appeared weaving together women fears fatness dark skin becoming old disabled implications incorporating visceral disgust examinations body image intersectional foundations women dreaded selves discussed imagining bodies may produce especially vivid narratives around social biases internalized oppression
parkinson disease characterized progressive loss dopaminergic neurons substantia nigra process leads dopamine deficiency striatum deficiency responsible development motor symptoms including resting tremor bradykinesia rigidity postural instability based observation substantial neuronal death alternatives parkinson disease treatment studied including cell based therapies present study aimed assess therapeutic potential intravenous intrastriatal transplant bone marrow mononuclear cells mouse model parkinson disease animals underwent stereotaxic surgery received injection hydroxydopamine medial forebrain bundle three weeks later mice injected bone marrow mononuclear cells saline caudal vein directly right striatum motor function assessed using rotarod apomorphine induced rotation tests results showed intrastriatal bone marrow mononuclear cells intravenous short term therapeutic effect dopaminergic response mice model parkinsonism assessed apomorphine induced rotation test phenomenon identified rotarod test showing dissociation dopaminergic response motor behavior experiments needed elucidate precise mechanisms involved effects elsevier rights reserved
paper consider binary transfer learning problem focusing select combine sources large pool yield good performance target task constraining scenario real world assume direct access source data rather employ source hypotheses trained propose efficient algorithm selects relevant source hypotheses feature dimensions simultaneously building literature best subset selection problem algorithm achieves state art results three computer vision datasets substantially outperforming transfer learning popular feature selection baselines small sample setting also present randomized variant achieves results computational cost independent number source hypotheses feature dimensions also theoretically prove reasonable assumptions source hypotheses algorithm learn effectively examples elsevier inc rights reserved
previous studies suggest bone loss fracture risk associated higher inflammatory milieu potentially modifiable diet primary objective analysis evaluate association dietary inflammatory index dii measure inflammatory potential diet risk hip lower arm total fracture using longitudinal data women health initiative observational study clinical trials secondarily evaluated changes bone mineral density bmd dii scores dii scores calculated baseline food frequency questionnaires ffqs completed participants mean age years without history hip fracture enrollment year ffqs used calculate dii change score fractures reported least annually hip fractures confirmed medical records hazard ratios fractures computed using multivariable adjusted cox proportional hazard models stratified age race ethnicity pairwise comparisons changes hip bmd measured dual energy ray absorptiometry baseline year year analyzed quartile least inflammatory diet baseline dii scores subgroup women mean dii score improved significantly years change associated fracture risk baseline dii score associated hip fracture risk younger white women significant associations among white women older years races ethnicities women least inflammatory dii scores less loss hip bmd year despite lower baseline hip bmd versus women inflammatory dii scores conclusion less inflammatory dietary pattern associated less bmd loss postmenopausal women inflammatory diet associated increased hip fracture risk white women younger years american society bone mineral research
much ink spilled regarding trials tribulations adapting formal methods needs software engineering practitioners exception computer scientists passion algorithm design optimization plethora greek letters symbols anathema whose first love writing code advent graphical modeling languages uml supporting tools generate production quality code executable modeling behavioral simulations bridging gap formalism coding paper proposes illustrative examples exploratory learning modality practicing engineer investigate empirically learn semantic mapping uml syntax semantic domains system instantiation reactive behavior
angioedema defined local noninflammatory self limiting edema circumscribed owing increased leakage plasma capillaries located deep layers skin mucosae two mediators histamine bradykinin account cases angioedema angioedema occur wheals manifestation urticaria form frequently allergic present review discuss nonallergic angioedema without wheals divided acquired hereditary forms histamine mediator acquired angioedema unknown etiology idiopathic histaminergic acquired angioedema whereas forms main mediator bradykinin angioedema caused inhibitor deficiency inh hereditary angioedema inh acquired angioedema mutations coagulation factor xii fxii hereditary angioedema treatment angiotensin converting enzyme inhibitors acei acquired angioedema etiology remains unclear acquired angioedema idiopathic nonhistaminergic acquired angioedema type hereditary angioedema hereditary angioedema unknown origin several treatments licensed hereditary inh deficiency plasma derived recombinant inhs bradykinin receptor blocker icatibant plasma kallikrein inhibitor ecallantide approved demand treatment reverse angioedema symptoms attenuated androgen plasma derived inh approved prophylaxis
family carbohydrate binding module thermotoga maritima beta mannanase tmcbm chosen carbohydrate active enzyme database computer aided design possessing lowest binding free energy mannopentaose improve enzymatic properties glycoside hydrolase family beta mannanase aspergillus usamii aumana two fusion beta mannanases aumana aumana designed fusing tmcbm terminus linked flexible peptide ggggs rigid peptide eaaak two fusion enzyme genes aumana aumana constructed designed theoretically overlapping pcr aumana two fusion genes expressed pichia pastoris three recombinant beta mannanases reaumana reaumana reaumana purified homogeneity specific activities temperature optimum reaumana degrees identical reaumana thermostability melting temperature reached degrees degrees degrees degrees higher latter respectively additionally values reaumana towards locust bean gum konjac gum guar gum significantly decreased reaumana cat catalytic efficiency values increased ing latter respectively results verified fusion tmcbm terminus aumana mediated eaaaic linker contributed improved thermostability catalytic efficiency society biotechnology japan rights reserved
root knot nematode meloidogyne incognita causes significant damage various economically important crops infection associated secretion effector proteins host cytoplasm interference host innate immunity combat infection identification functional annotations excretory secretory proteins serve key produce durable control measures identification proteins experimental methods expensive time consuming bioinformatics approaches cost effective prioritizing experimental analysis potential drug targets parasitic diseases study predicted functionally annotated proteins incognita genome using integration several bioinformatics tools proteins orthologues free living nematode caenorhabditis elegans parasitic nematodes whereas appeared novel incognita specific molecules elegans homologues proteins loss function phenotype rna interference could represent potential drug targets parasite intervention control could functionally annotate proteins using gene ontology terms proteins protein domains established pathway associations sequences using kyoto encyclopaedia genes genomes kegg proteins also mapped several important plant cell wall degrading cazyme families including chitinase cellulase xylanase pectate lyase endo beta xylanase comprehensive analysis incognita secretome provides functional information experimental study elsevier ltd rights reserved
aimto assess incidence associated risk factors asymptomatic urinary retention elderly women upon admission internal medicine department methodstwo hundred two consecutive elderly women mean age years admitted four internal medicine departments tertiary medical center prospectively enrolled patients underwent post void residual urine pvr measurements morning following admission day measurements undertaken using portable ultrasound bladder scan asymptomatic urinary retention defined pvrml without lower urinary tract symptoms abdominal pain two consecutive measurements resultsasymptomatic urinary retention diagnosed women mean pvr range mean age prevalence chronic diseases use opioid antimuscarinic drugs similar women versus without asymptomatic urinary retention binary logistic regression analysis showed asymptomatic urinary retention significantly independently associated low mobility measured functional independence measure fim scale odds ratio confidence interval hypothyroidism odds ratio confidence interval among patients thyroid stimulating hormone tsh serum levels measured statistically significant correlation demonstrated tsh values pvr measurements conclusionsasymptomatic urinary retention elderly women upon admission internal medicine department infrequent independently associated hypothyroidism low mobility pvr measurements therefore considered women low level mobility hypothyroidism upon admission internal medicine department neurourol urodynam wiley periodicals inc
purpose paper twofold develop sound complete rules along algorithms data structures construct network voronoi diagram nvd road network compute nvd attention focused distinguish divisible paths others whose midpoints exactly border points research shows dominance relation introduced paper plays important role making distinction generate prune candidate paths concurrently border point binary tree introduced pre computed nvd organized linked lists available access nvd list based query search method nvdl compute single step experiments show nvdl method reduces execution time sparse data distribution real road network compared existing ine method nvdl query time remains nearly constant regardless data points distributed road network query point positioned addition approach prevents nvdl experiencing slow convergence condition often occurs using incremental approach elsevier rights reserved
eating pathology seasonal affective disorder sad may severe hyperphagia winter although research documented elevated rates subclinical binge eating women sad prevalence correlates binge eating disorder bed sad remain largely uncharacterized examined prevalence correlates binge eating weekly binge eating distress bed defined dsm sad also tested whether binge eating exhibits seasonal pattern among individuals bed two samples combined form sample individuals sad third sample included non depressed adults clinical subclinical bed participants completed questionnaire eating weight patterns revised qewp modified seasonal pattern assessment questionnaire spaq sad sample reported binge eating met criteria weekly binge eating distress met criteria bed atypical symptom severity predicted binge eating bed bed sample endorsed seasonal worsening mood reported winter pattern binge eating spectrum eating pathology sad includes symptoms bed associated atypical depression symptoms typical depression symptoms elsevier ireland ltd rights reserved
technical university cluj napoca lighting engineering laboratory lel main lighting independent consultant around transylvania north west side romania among lot private companies town halls national regional authorities require lel consultancy designing new lighting solutions lighting refurbishment university greatest lecture hall led dedicated control solution success starting point new strategy greener university finalised survey energy efficiency lighting techniques presented technical university cluj napoca financed year internal energy efficiency project aiming determine present energy consumption university buildings starting present consumption based tested energy efficiency implemented solutions eco active building concept developed living building lab main design proposals presented authors published elsevier ltd
background worldwide infertility affects couples seek medical help including assisted reproductive technology art treatments undergoing art treatments create many physical emotional burdens study examined psychological consequences infertility iranian infertile males females well spouses unlike previous studies examined mainly females infertility methods subjects descriptive analytical design recruited ivf department mirza koochak khan hospital rouyesh infertility treatment center tehran iran aug sep overall couples response rate consisting infertile male spouses infertile female spouses included research psychological disorders measured persian version symptoms checklist revised cattle inventory results psychological disorders infertile couples significantly associated increasing age higher education longer duration infertility unemployment prevalence anxiety depression hypochondriasis paranoia infertile females spouses infertile males significantly higher husbands infertile females obsession sever infertile females significantly greater infertile males depression significantly lower infertile males spouses conclusion iranian infertile females spouses infertile males experienced psychological disorders infertile males spouses infertile females results may due impact cultural beliefs gender roles iranian society anxiety depression obsession paranoia hypochondriasis addressed art treatments
trauma extremities disproportionately represented casualties recent conflicts accounting injuries sustained operations iraq afghanistan infectious complications reported evacuated trauma patients treated intensive care unit icu osteomyelitis reported intensive care unit patients deep wound infection type iii open tibia fractures infections complicating extremity trauma frequently caused multidrug resistant bacteria demonstrated lead failure limb salvage unplanned operative take backs late amputations decreased likelihood returning duty invasive fungal infections extremities also presented unique challenge combat injured patients particularly blast injuries massive transfusion requirements high injury severity scores infection prevention begin time injury although context specific depending level care includes appropriate irrigation surgical debridement wound care coverage fracture fixation antibiotic prophylaxis addition basic infection prevention measures clinical practice guidelines address infection prevention combat trauma including extremity infection developed revised endorsement surgical infection society infectious disease society america nevertheless significant challenges remain including austere environments care multiple transitions care lack coordinated efforts prevention treatment established infections optimally multidisciplinary particularly deep wounds bone joints involved surgical debridement overtly infected necrotic tissue necessary particularly aggressive margins invasive fungal infection suspected infected nonunion frequently requires use prosthetic materials fixation potentiating biofilm formation complicating medical therapy antibiotic therapy targeted results deep wound bone cultures however complicated frequent contamination wounds requiring differentiation potential pathogens terms virulence decreased culture recovery patient frequently received previous antibiotics lessons learned infection prevention treatment orthopaedic trauma combat serve inform care patients injured natural disasters noncombat trauma
thoth standalone software application graphical user interface making easy query display visualize analyze tabular data stored relational databases data files imported data tables create pie charts bar charts scatter plots many kinds data graphs simple menus mouse clicks programming required leveraging open source jfreechart library also computes useful table column data statistics mature tool underwent development testing several years written java computer language hence run computing platform java virtual machine graphical display capability downloaded used anyone free charge general applicability science engineering medical business fields special tools features common tasks astronomy astrophysical research included software published elsevier
end stage failing heart valves currently replaced mechanical biological prostheses types positively contribute restore physiological function native valves number drawbacks limits expected performances order improve outcome tissue engineering offer alternative approach design fabricate innovative heart valves capable support requested function promote formation novel viable correctly operating physiological structure potential result particularly critical referred aortic valve one mainly exposed structural functional degeneration regard proposed study presents fabrication vitro characterization bioresorbable electrospun heart valve prosthesis using particle image velocimetry technique either physiological pathological fluid dynamic conditions scaffold designed reproduce aortic valve geometry also mimicking fibrous structure natural extracellular matrix evaluate performances possible implantation flow fields downstream valve accurately investigated compared experimental results showed correct functionality device supported formation vortex structures edge three cusps reynolds stress values threshold risk hemolysis comprised range depending exposure period good structural resistance mechanical loads generated driving pressure difference elsevier ltd rights reserved
along molecular abnormalities mutations jak calreticulin calr mpl genes chronic inflammation major hallmark myelofibrosis investigated vitro effects crucial factors inflammatory microenvironment interleukin beta tumor necrosis factor tnf alpha tissue inhibitor metalloproteinases timp atp functional behaviour derived circulating cells found regardless mutation status beta tnf alpha increases survival derived cells addition along stimulation cell cycle progression phase beta tnf alpha timp significantly stimulate vitro clonogenic ability cells jak mutated patients whereas jak mutated group addition beta tnf alpha timp decreased erythroid compartment calr mutated patients megakaryocyte progenitors stimulated beta jak mutated patients inhibited tnf alpha beta tnf alpha motif chemokine cxcl timp highly stimulates vitro migration derived cells interestingly migration toward beta tnf alpha cxcl timp cells jak mutated patients show increased clonogenic ability demonstrate interplay inflammatory factors promotes selects circulating derived cells higher proliferative activity clonogenic potential migration ability targeting micro environmental interactions may clinically relevant approach
background onabotulinumtoxina onabota considered effective patients chronic migraine failed traditional therapies study designed evaluate effect onabota injection series migraine outcome negative emotional states sleep quality patients methods total patients mean age years female included data pittsburgh sleep quality index psqi headache frequency severity number analgesics used migraine disability assessment scale midas scores depression anxiety stress scale dass evaluated baseline visit consecutive follow visits conducted onabota injection series week visit week visit week visit week visit evaluate change baseline follow results baseline visit significant decrease noted least square mean headache frequency rho headache severity rho number analgesics rho midas scores rho significant change baseline noted global psoi dass scores throughout study conclusions findings revealed onabota therapy associated significant improvement migraine outcome leading decrease headache frequency severity number analgesics used midas scores significant change noted overall sleep quality prevalence negative emotional states patients without negative emotional states baseline showed improved sleep quality throughout study
power system simulation software tools traditionally designed serial codes optimized using single processor computers inadequate terms computational efficiency execution time ever increasing complexity power grid due mentioned sequential computing demerits paper used matlab data parallelism message passing interface software execute lagrange particle swarm optimization pso algorithms parallel multiple processor units different large data sets solution combined economic emission dispatch ceed problem two important advantages using parallel computing approach solve power system economic dispatch problem increase efficiency solution quality reduce execution time speed parallelization process ceed problem solution comparison lagrange pso data parallel solution quality execution time presented ceed problem institute electrical electronic engineers ieee bus ieee bus systems paper contributes line real time market analyses deregulated power system need improved solution quality fast computation process solve power system energy management ceed problems proper discussion decision making control center level
counting solution number combinational optimization problems important topic study computational complexity concerned vertex cover paper first investigate organizations vertex cover solution spaces underlying connectivity unfrozen vertices provide facts global local environment vertex cover solution number counting algorithm proposed complexity analysis provided results fit well simulations better performance rsb neighborhood random graphs based algorithm variation fluctuation solution number statistics studied reveal evolution mechanism solution numbers furthermore marginal probability distributions solution space investigated random graph scale free graph illustrate different evolution characteristics solution spaces thus solution number counting based graph expression solution space alternative meaningful way study hardness complete complete problems appropriate algorithm design help achieve better approximations solving combinational optimization problems corresponding counting problems
introduction impact pregnancy related health warning labels hwls appearing cigarette packages women reproductive age socio demographic groups well understood current study analyzes different age gender groups respond pregnancy related hwls compared non pregnancy hwls methods data analyzed four waves online longitudinal study adult smokers aged australia canada mexico participants classified four dge gender groups women men women men participants rated one pregnancy related several non pregnancy related labels worry believability motivation quit country specific adjusted linear gee estimated regressing ratings three key outcomes pregnancy related hwls rating difference score subtracted average ratings non pregnancy warning rating pregnancy warning models adjusted socio demographics smoking related variables results mexico australia graphic pregnancy related hwl imagery used premature infant women reproductive age reported stronger believability worry quit motivation groups results similar text hwls used contrast canada pregnancy related hwl imagery features pregnant woman ratings unassociated gender age groups stronger effects among women reproductive age limited pregnancy hwls country except canada conclusions hwls depict graphic effects illustrate smoking related pregnancy risks appear perceived particularly effective among women reproductive age elsevier ltd rights reserved
many circumstances concepts ideas emotions mainly conveyed colors color vision disorders heavily limit user experience accessing information society therefore color vision impairments taken account order make information services accessible broader audience task easy designers generally affected color vision disorder case design accessible user interfaces lead boring color schemes selection appealing harmonic color combinations preserved past research investigated generative approach led evolutionary computing supporting interface designers make colors accessible impaired users approach also followed authors contribution paper provide experimental validation claim approach actually beneficial designers users
pigment epithelium derived factor pedf neurotrophic factor neuroprotective anti tumorigenic anti angiogenic effects elevated levels pedf previously proposed cerebrospinal fluid csf biomarker alzheimer disease however origin pedf csf whether derived brain systemic circulation specificity finding hitherto remained unclear analyzed levels pedf paired csf serum samples elisa patients alzheimer disease frontotemporal dementia ftd vascular dementia bacterial meningitis multiple sclerosis pseudotumor cerebri diverse non inflammatory neurological diseases established csf serum quotient diagrams determine fraction intrathecally synthesized pedf csf found pedf significantly increased csf patients ftd bacterial meningitis remarkably pedf concentrations also significantly elevated serum patients csf serum quotient diagrams demonstrated elevated pedf concentrations csf patients mostly due elevated pedf concentrations serum findings underscore importance relating concentrations proteins csf respective concentrations serum avoid erroneous interpretations increased protein concentrations lumbar csf elsevier rights reserved
conventional high torque low speed drive systems commonly mechanical transmission induction motor load consisting gears gear heads belt pulleys camshafts main drawbacks setups deficiency drive system high cost maintenance needs alternative replacement induction motor mechanical transmission elements permanent magnet synchronous motor pmsm directly coupled load running low speed context paper deals design evaluation rpm motor concentrates two radial flux promising topologies surface mounted permanent magnets inner outer rotor since goal mainly minimization machine active weight respect constraints related outer dimensions efficiency cost designs machines conducted solving optimization problem three optimization methods adopted three weighted cost functions presented effectiveness methods finding competitive alternative pmsm designs evaluated presented results compared found literature reveal satisfactorily enhanced design solutions performance proposed methods
ripening related firmness loss shortens considerably storage potential sweet cherry prunus avium thus limiting postharvest handling transportation commercialisation biochemical mechanisms underlying process cherries fully understood mechanisms operating given fruit may extrapolated different species cell wall materials obtained untreated calcium treated celeste sweet cherries fractionated analysed cold storage related enzyme activities gene expression assessed calcium treated fruit firmer lower weight loss decay incidence controls accumulation beta gal paexp transcripts strongly inhibited cold stored fruit although expression levels recovered largely three days shelf life data suggest pectin methylesterase beta galactosidase expansin activities may control access additional proteins substrates possible role apoplastic redox status modulation process also discussed elsevier rights reserved
calcitonin gene related peptide cgrp amino acid peptide found primarily delta sensory fibers arising dorsal root trigeminal ganglia well central nervous system calcitonin gene related peptide found play important roles cardiovascular digestive sensory functions although vasodilatory properties cgrp well documented somatosensory function regarding modulation neuronal sensitization enhanced pain received considerable attention recently growing evidence indicates cgrp plays key role development peripheral sensitization associated enhanced pain calcitonin gene related peptide implicated development neurogenic inflammation upregulated conditions inflammatory neuropathic pain likely cgrp facilitates nociceptive transmission contributes development maintenance sensitized hyperresponsive state primary afferent sensory neurons also second order pain transmission neurons within central nervous system thus contributing central sensitization well maintenance sensitized neuronal condition believed important factor underlying migraine recent successful clinical studies shown blocking function cgrp alleviate migraine however mechanisms cgrp may contribute migraine still fully understood reviewed role cgrp primary afferents dorsal root ganglion trigeminal system well role peripheral central sensitization potential contribution pain processing migraine
background emergency contraception significantly reduce rate unintended pregnancies unsafe abortions especially sub saharan africa despite increasing awareness among educated young women nigeria rate utilisation remains low study therefore explores main barriers use among female university students analysing knowledge emergency contraception methods ever used perceived efficacy acceptability methods paper brings together findings several focus groups depth interviews conducted amongst unmarried female undergraduate students two nigerian universities results participants considered use condom abstinence effective methods preventing unplanned pregnancy however many participants misinformed emergency contraception generally participants relied unconventional unproven ecs ampiclox alabukun salt water solution lime potash perceived effective preventing unplanned pregnancies furthermore respondents narratives methods preventing unwanted pregnancies revealed inadequate information emergency contraception reliance unproven crude contraceptive methods misconception modern contraception constitute barriers use emergency contraception conclusions findings suggested female university students misinformed emergency contraception reliance unproven ecs constitutes barrier use approved methods barriers serious implications prevention unplanned pregnancies cohort behavioural interventions targeting use unproven emergency contraceptive methods misperceptions ecs would crucial cohort nigeria
purpose purpose paper apply insights social role theory trust repair highlighting underexplored implications gender trust repair may difficult following violations incongruent transgressor gender role design methodology approach paper reviews research trust repair particularly kim discovery apologizing internal attributions best ability related violations denying responsibility best integrity related violations propositions trust repair grounded attribution social role theory findings trust violations may incur bigger backlash incongruent gender roles particularly individuals gender incongruent professions cultures low gender egalitarianism men may find ability related violations difficult repair women may find repairing benevolence integrity related violations difficult apologies offered attributions consistent gender roles internal attributions men external attributions women may effective practical implications gender relevant factor trust repair policies training addressing conflict consider differences manifest originality value gender role differences largely overlooked trust repair integrating social role theory exploring benevolence based violations paper offers complete understanding trust repair
introduction family centered care fcc health care delivery approach endorsing support participation families date little research addressed associations fcc adaptation outcomes specifically context pediatric cancer main objective research identify direct indirect associations caregiving burden parents fcc quality life qol life satisfaction method participants parents children diagnosed cancer parents answered measure processes care questionnaire evaluate perceptions fcc domains family centered services provision general information perceptions caregiving burden revised burden measure qol eurohis qol life satisfaction satisfaction life scale also assessed pediatric oncologists provided information child diagnosis treatment status results findings showed parents perceived children health care family centered also reported lower caregiving burden family centered services indirectly linked qol life satisfaction caregiving burden discussion research suggests way parents perceive formal care namely less family centered may influence burden experience caregivers child cancer indirectly adaptation findings highlight relevance gaining greater understanding interaction family health care systems context pediatric cancer
one important challenges decade internet things iot pursues integration real world objects virtual world internet one property characterises iot systems react variable continuous changes means iot systems need work self managed systems effectively manage context changes autonomy property inherent software agents makes suitable choice developing self managed iot systems embedding agents devices compose iot possible realize decentralized system self management capacities however scenario new problems arise firstly current agent development approaches lack mechanisms deal heterogeneity present iot domain secondly agents must simultaneously deal potentially conflicting changes behaviour concerning self management application goals order afford challenges propose use approach based dynamic software product lines spl preference based reasoning spl provides preference based reasoning agent necessary information adapt behaviour runtime making trade self management system accomplishment application goals
massive mimo promising technology strong candidate future generation wireless systems paper describes aspects realistic algorithm design antenna prototype including low complexity algorithms feasible designs equivalent channel acquisition srs sinr estimation cqi estimation dmrs design irc receiver implementation etc finally link level simulation shows effectiveness benefits proposed algorithms designs
present work strength materials based approach used determination effective coupled thermo electro mechanical tem properties piezoelectric fiber reinforced composite pfrc rectangular representative volume element rve rectangular fibers considered dependencies effective coupled thermo electro mechanical coefficients pfrc fiber volume fraction studied results obtained electro mechanical coefficients compared already published results mallik ray effective coefficients piezoelectric fiber reinforced composites aiaa ray micromechanics piezoelectric composites improved effective piezoelectric constant int mech mater des show excellent agreement results also show effective thermal coefficients reduced effective pyroelectric coefficients pfrc increased fiber volume fraction range compared bulk piezoelectric materials model predicts strong dependence effective coefficients pfrc fiber volume fraction well elastic properties matrix elsevier ltd rights reserved
identifying contents black box electrical circuit challenging experiment paper present approach identifying topological structure circuit estimating values internal components applying input signals measuring available signals black box model provided simulink model whose contents accessible students overall procedure performed matlab simulink environment results obtained given circuit compared actual values experiment performed group undergraduate students assessment results show effectiveness challenging knowledge
article presents meta analysis studies yielding independent samples subjects relationship exposure media violence violent aggression mean effect sizes aggregate experimental studies suggest media violence criminal aggression positively associated findings prospective longitudinal studies ambiguous summary statistics based models strictly conforming study original design compared post hoc models measures model specification consistent original description overall original models controlling trait suggest exposure media violence associated criminal aggression summary statistic boys reached statistical significance effect size small conclusions based finding attenuated known biases coefficients estimated
objective evaluate long term transverse anteroposterior vertical skeletal changes rapid maxillary expansion rme data clinical trials assessed skeletal changes cephalometric analysis surgical simultaneous treatment evaluation period accepted electronic databases pubmed medline medline process non indexed citations cochrane database systematic reviews asp journal club dare cctr embase web sciences lilacs searched help senior health sciences librarian abstracts appeared fulfill initial selection criteria selected consensus original articles retrieved methodological checklist used evaluate quality selected articles references also hand searched possible missing articles articles without adequate control group factor growth changes excluded three articles one measuring transverse two anteroposterior vertical changes measured rme stability active expansion methodological flaws limit attainable conclusions individual analysis articles made long term transverse skeletal maxillary increase approximately total dental expansion prepubertal adolescents better long term outcomes expected transverse changes rme less skeletally mature patients rme appears produce clinically significant anteroposterior vertical changes position maxilla mandible conclusions systematic review considered caution secondary level evidence found long term randomized clinical trials needed
background child maltreatment severe short long term consequences children health development wellbeing despite provision child protection education programs many countries rigorously evaluated determine effectiveness describe design multi site gold standard evaluation australian school based child protection education program intervention developed profit agency comprises sessions delivered first grade students aged years regular classrooms incorporates common attributes effective programs identified literature aligns australian education curriculum methods design three site cluster randomised controlled trial rct learn safe emmy friends conducted children approximately first grade classrooms queensland primary elementary schools three state regions period years entire schools randomised using computer generated list random numbers intervention wait list control conditions prevent contamination effects across students classes data collected baseline pre assessment immediately intervention post assessment months follow assessments outcome assessors blinded group membership primary outcomes assessed children knowledge program concepts intentions use program knowledge skills help seeking strategies actual use program material simulated situation anxiety arising program participation secondary outcomes include parent discussion monitor parent observations children use program materials satisfaction program parental stress process evaluation conducted concurrently assess program performance discussion rct addresses shortcomings previous studies methodologically extends research area randomising school level prevent cross learning conditions providing longer term outcome assessment previous study examining degree parents guardians discuss intervention content children home assessing potential moderating mediating effects family child demographic variables testing vivo measure assess children ability discriminate safe unsafe situations disclose trusted adults testing enhancements existing measures establish greater internal consistency
many applications local time stepping offers interesting worthwhile alternative well established global time step control fact local time stepping allow highly detailed resolution localized features solution strongly reduced computational cost compared global time step control however local time stepping applicable straight forward manner context fully implicit time discretizations present method efficient parallel adaptive solution non linear partial differential equations particular reaction diffusion equations using spatially adapted time step sizes context fully implicit solution strategy proposed method uses discontinuous galerkin method time approach within full space time approach moreover designed scratch efficient parallel computation employ shallow tree based mesh data structures order ensure low memory footprint adaptive meshes solving time dependent partial differential equation dimensional non conforming mesh space time adaptivity naturally achieved combination discontinuous galerkin method time size arising systems precisely controlled additionally introduce discuss stabilization scheme space time mortar element methods also highly positive impact efficiency preconditioning techniques arising systems equations present results extensive numerical experiments address question convergence efficiency linear non linear solver performance parallel scalability tip cores well accuracy linear heat equation real world non linear reaction diffusion equation field computational electrocardiology elsevier inc rights reserved
multi output boolean functions also called boxes various measures nonlinearity widely discussed literature many problems left open topic purpose paper present new approach estimating nonlinearity boxes fine grained view notion nonlinearity boxes presented new connections linear codes established precisely mainly study nonlinearity indicator denoted boxes coding theory point view cryptographic parameter related best affine approximation attacks stream ciphers establish direct link minimum distance corresponding linear code exploit connection derive first general lower bounds non affine functions dividing furthermore show determined directly weight distribution corresponding linear code
web browser new desktop many users spend time using browser browser also become host rich dynamic applications previously tailored individual operating system lingua franca web scripting javascript pivotal development imagine desktop applications allocated memory single heap managed operating system reclaim memory upon application shutdown processes would garbage collected one quit operating systems improved upon approach long ago browsers managed memory recently article explores compartmentalized memory management approach tailored specifically web browsers idea partition javascript heap compartments allocate objects compartments based origin objects compartment reference direct whereas cross origin references wrapper objects carefully evaluate techniques using mozilla firefox browser ships enhancements demonstrate benefits collecting compartment independently simultaneously improves runtime performance reduces garbage collection pause times well memory footprint browser addition enforcing origin security policy becomes simple efficient compartments
world health organisation estimates global population similar billion people lack access electricity furthermore global population similar billion people rely traditional use biomass cooking oedc iea study details development prototype electrical generator portable stoves commonly use developing world generator capable delivering small amounts grid electricity power generated using thermoelectric effect single thermoelectric module utilised convert small portion heat stove electricity electricity produced used charge single lithium iron phosphate battery drive low power fan well auxiliary features airflow produced fan used conjunction commercially available heat pipe heat sink maintain adequate temperature difference across thermoelectric module experiments laboratory maximum teg power output obtained average energy stored battery typical long burn three long burns produced sufficient energy fully charge battery performance electricity generating cooking stove subsequently tested malawi using locally sourced fuel fire stoking methods elsevier ltd rights reserved
study explores conceptions research undergraduate pre service teachers english language major public mexican university pragmatist definition research survey design used informants pre service efl teachers second sixth tenth semesters major conceptions research showed similar percentages among pre service teachers semesters slight variation found factor misconceptions research factor research problem solving one showed significant weak correlation semester undergraduate pre service efl teachers slight differences also found age range conceptions research overall lack differences among research conceptions undergraduate pre service efl teachers opposed findings previous studies explained fact studies done different contexts graduate students disciplines different foreign language teaching suggested students misconceptions corrected research activities promoted studies
paper presents eso based control design ball beam system one sought problem control engineering students system comprises long beam moved using servo motor ball rolls respect beam motion design estimation virtual state disturbance carried online state observer states used controller nullify effects actual disturbances uncertainties plant designing controller simpler model used thus avoiding accurate modeling system nonlinear term unknown parameter plant considered internal external disturbance peculiar feature automatic disturbance rejection control eso based control scheme hence linearized model ball beam considered simulations carried help matlab simulink using algorithm controller shows good disturbance rejection capability shown simulation results ifac international federation automatic control hosting elsevier ltd rights reserved
style styles specific way expressing particular area human activity certain purposes communication based definition relating performance context volleyball decided conduct study communication style female volleyball players official game style communication sport environment called nonverbal communication target group consisted female players csu medicina tirgu mures team plays first volleyball division romanian national championship participated last seasons challenge cup study conducted competitive season consisted exemplifying ways communication players game coordinator teammates study aims highlight existence different style communication especially nonverbal communication represents starting point involved sports life beyond
recalling positive autobiographical memories powerful strategy repair affect positive memory recall operates reparative strategy enhancing positive affect facilitates regulation negative affect individual differences however ability use positive material repair mood participants elevated depression scores example less likely profit strategy depression associated elevated fear positive emotion current study examined whether elevated fear positive emotion associated depression related difficulties mood repair ninety four participants first underwent mood repair task sad mood induction followed cue recall positive autobiographical memories subjective measures state happiness sadness collected across mood induction positive memory recall procedures results revealed greater fear positive emotion linked less ability enhance positive affect regulate negative affect using positive memories results also provided preliminary support mediation model greater depressive symptoms predicted elevated fear positive emotion turn predicted less ability repair positive affect findings highlight fear positive emotion potential target interventions aimed improving affect regulation
consider linear quadratic optimal sampled data control problems state evolves continuously time according linear control system control sampled piecewise constant subdivision time interval cost quadratic first result prove sampling periods tend zero optimal sampled data controls converge pointwise optimal permanent control extend classical riccati theory sampled data control framework developing two different approaches first one uses recently established version pontryagin maximum principle optimal sampled data control problems second one uses adequate version dynamic programming principle turn obtain closed loop expression optimal sampled data controls linear quadratic problems elsevier ltd rights reserved
serious games foster acquisition complex problem solving skills assessment skills line instruction within serious game environment content validity equal face face assessment research assessment serious gaming remained rather scarce article shows assessment implemented serious gaming way assures content validity core authors validation method entails mapping learning activities contained game scenario performance indicators outputs derived formal attainment levels present elaborated applied method assessment game ict managers secondary vocational education describe procedure extent assessment content valid compared face face assessment
neuropsychiatric events systemic lupus erythematosus patients may present diagnostic therapeutic challenge common heterogeneous characterization attribution systemic lupus erythematosus non systemic lupus erythematosus important derived clinical assessment selection interpretation investigations standardized approach assigning attribution used recent studies current therapies largely empiric based upon known disease mechanisms treatment serious organ disease systemic lupus erythematosus insight immunopathogenetic mechanisms clinical outcome neuropsychiatric systemic lupus erythematosus required inform design execution therapeutic clinical trials
paper constitutive model developed unidirectional natural fiber reinforced composite materials describe mechanical degradations subjected long term hydrothermal ageing two internal variables reflect effects moisture absorption hydrolysis reaction incorporated helmholtz free energy energy dissipations within non equilibrium thermodynamic framework furthermore specific forms modified helmholtz free energy employed study constitutive behaviors composite damage evolution laws hydrothermal ageing processes established apply theoretical model analyze elastic responses composite long term hydrothermal ageing present theoretical predictions found agreement existing experimental results shows moisture absorption related damage develops rapidly reaches plateau within days resulting sharp decrease elastic modulus composite early ageing stage whereas evolution deterioration associated hydrolysis reaction much slower rate elsevier ltd rights reserved
people regularly take prosocial actions making individual sacrifices greater good similarly people generally avoid causing harm others twin desires good avoid harm often align sometimes diverge creating situations moral conflict examined moral conflict using modified dictator game participants chose much money allocate away recipient designated orphan creating sense harm money reallocated either participant charity people strongly prosocial allocated money away orphan charity furthermore people left money orphan harm framed means taking side effect splitting predicted dual process theories moral decision making response times longer take action positively correlated amount taken orphan concluded people take positive actions greater good similarly willing cause harm benefits others rather
manufacturers exploring innovative strategies achieve sustain competitive advantages facing new era intensive global competition strategy supply chain management scm gained tremendous amount attention researchers practitioners since last decade supply chain management scm considered popular operations strategy improving organizational competitiveness twenty first century attracted lot attention recently due role involving activities industrial organizations ranging raw material procurement final product delivery customers well designed supply chain systems substantially improve efficiency product quality eventually enhance customer satisfaction profitability paper manufacturing engineering perspective supply chain integration presented research issues discussed include product process design supply chain design valuation manufacturing supply chain agent based techniques supply chain integration intelligent information sharing across supply chain development standards product process production data exchange facilitate electronic commerce objective provide guidelines references manufacturing engineers researchers interested supply chain integration
mufas unsaturated fas one double bond derived endogenous synthesis dietary intake accumulating evidence suggested plasma erythrocyte mufa levels associated cardiometabolic disorders including cvd metabolic syndrome previous genome wide association studies gwass identified seven loci plasma erythrocyte palmitoleic oleic acid levels populations european origin identify additional mufa associated loci potential functional variant locus performed ethnic specific gwas meta analyses trans ethnic meta analyses participants chinese european ancestry identified novel genome wide significant associations vaccenic acid fads pkdl log bayes factor gondoic acid fads gckr log bayes factor also observed improved fine mapping resolutions fads gckr loci greatest improvement observed gckr number variants credible set reduced covering covering including missense variant trans ethnic meta analysis also confirmed previously reported associations pkdl fads gckr hifan palmitoleic acid fads lpcat oleic acid chinese specific gwas trans ethnic meta analyses pathway based analyses suggested identified loci unsaturated metabolism signaling pathways findings provide novel insight genetic basis relevant mufa metabolism biology
scheduling multiple parallel workflows arrive different instants heterogeneous distributed computing systems great challenge different requirements resource providers users overall scheduling length main concern resource providers whereas deadlines workflows major requirements users algorithms use fairness based strategies reduce overall scheduling length however algorithms cause obvious unfairness longer makespan workflows shorter makespan workflows furthermore systems meet deadlines workflows particularly large scale resource constrained computational grids gaining reasonable balance overall scheduling length deadlines workflows desirable goal study first propose fairness based scheduling algorithm called fairness based dynamic multiple heterogeneous selection value achieve high performance systems compared existing works meet deadlines partial higher priority workflows present priority based scheduling algorithm called priority based dynamic multiple heterogeneous selection value finally combining fairness based dynamic multiple heterogeneous selection value priority based dynamic multiple heterogeneous selection value present tradeoff based scheduling algorithm meet deadlines higher priority workflows still allowing lower priority workflows processed actively better performance systems example extensive experimental evaluations demonstrate significant improvement proposed algorithms copyright john wiley sons ltd
activation induced cytidine deaminase aid relative apobec cytidine deam inases boost immune response mutating immune viral genes genome mutating activities aid apobecs also drivers tumorigenesis due highly charged surfaces extensive non specific protein protein nucleic acid interactions formation polydisperse oligomers general insolubility structure elucidation proteins ray crystallography nmr challenging hence almost available aid apobec structures mutated truncated versions reported functional structure aid using combined computational biochemical approach described new regulatory mechanism first human dna rna editing enzymes mechanism involves dynamic closure catalytic pocket subsequent ray nmr studies confirmed discovery showing apobecs also close catalytic pockets highlight catalytic pocket closure emerging important regulatory mechanism aid apobecs focus three sub topics first propose variable pocket closure rates across aid apobecs underlie differential activity immunity cancer review supporting evidence second discuss dynamic pocket closure ever present internal regulator contrast proposed regulatory mechanisms involve extrinsic binding partners third compare merits classical approaches ray nmr emerging computational biochemical approaches structural elucidation specifically aid apobecs
aims self reported information questionnaires frequently used clinical epidemiological studies provide information reproducibility instruments applied secondary coronary prevention studies study aims assess test retest reproducibility questionnaire applied cross sectional norwegian coronary cor prevention study methods cor study coronary heart disease chd patients completed self report questionnaire consisting questions validated instruments novo questions test retest reliability instrument estimated four weeks consecutive coronary patients intraclass correlation coefficient icc kappa calculated results mean interval test retest days reproducibility values questions first part questionnaire differ latter good good reproducibility found lifestyle factors smoking exercise icc medical factors drug adherence icc sleep apnoea icc psychosocial factors anxiety depression icc quality life item short form health survey icc well majority novo created variables covering patient perceptions motivation needs preferences conclusions present questionnaire demonstrates highly acceptable reproducibility key items instruments thus emerges valuable tool evaluating patient factors associated coronary risk factor control chd patients
instituto astronomia universidad nacional autonoma mexico unam along instituto nacional astrofisica optica electronica university arizona smithsonian astrophysical observatory developing telescopio san pedro martir tspm project diameter optical telescope engineering technology corp design construction management firm responsible site infrastructure enclosure support facilities telescopio san pedro martir project tspm located within san pedro martir national park baja california mexico sea level approximately east pacific ocean west sea cortes gulf california south united states mexico border aim paper present preliminary design site infrastructure enclosure support facilities date share design construction approach
aim previous studies reported outstanding amount injuries taekwondo competitions dominant mechanism results physical contact athletes therefore training program designed considering physiological stress competition athlete would perform pad instead real opponent order prevent injury preparatory competition methods twelve elite taekwondo players selected ages years height weight max measured using bruce exhaustive test min anaerobic power measured using rast field method heart rate alterations determined using rpe borog scale competition three intervals periods round end third round blood lactate concentration evaluated competition evaluate ratio fighting non fighting activity digital video camera used simulation taekwondo players performed motor skills simulating competition pads change blood lactate rpe measured compared competition conditions opponents data compared one way repeated measurement analysis variance anova results significant differences observed two conditions competition simulation training rpe variables conclusion apparently simulation training inflicts physiological stress elite athletes may replaced preparatory competitions tournament avoid possible sports injuries
purpose background aim study examine effects memantine adjuvant treatment obsessive compulsive symptoms patients bipolar disorder type manic phase methods procedures week double blind placebo controlled randomized clinical trial patients manic phase symptoms randomly allocated receive memantine placebo plus routine medications lithium olanzapine clonazepam yale brown obsessive compulsive behavior scale used assess outcomes adverse effects also recorded findings results thirty eight patients memantine group placebo group completed trial throughout trial mean score decreased memantine group placebo group end study patients memantine group patients placebo group demonstrated decline yale brown obsessive compulsive behavior scale score serious adverse effects reported implications conclusions double blind controlled clinical trial showed memantine effective adjuvant agent reducing symptoms patients however needs noted study preliminary larger double blind controlled studies needed confirm results
urgent need identify signs harbinger onset borderline personality disorder bpd advancement area required refine developmental theories discover etiological mechanisms improve early detection achieve ultimate goal prevention though many studies supported wide range factors increase subsequent risk bpd literature yet critically evaluated comprehensive reviews examine integrate findings address limitation conducted systematic review summarize synthesize current literature electronic databases systematically searched prospective longitudinal studies examined risk factors subsequent bpd outcomes features symptoms diagnosis resulting total studies reflecting unique samples though increased risk bpd reliably attributed multiple factors within social family maltreatment child domains striking limitation research lack disorder specific findings additional limitations including notable heterogeneity sampling methodology symptom assessment methodology developmental timing assessments discussed terms close pinpointing risk attempt provide roadmap future research
age associated changes lung structure function important predictors overall health cognitive activities longevity common aging cells increase oxidatively modified dna bases primarily oxo dihydroguanine oxog repaired via dna base excision repair pathway driven oxoguanine dna glycosylase ogg ber whose role aging focus many studies study hypothesizes signaling consequent gene expression cellular response ogg ber wires senescence aging processes test ogg ber mimicked repeatedly exposing diploid lung fibroblasts cells airways mice oxog base results showed repeated exposures led cell cycle arrest pre matured senescence cultured cells genes differentially expressed identical naturally senesced cells gene ontology analysis gene expression displayed biological processes driven small gtpases phosphoinositide kinase mitogen activated kinase cascades cultured cells lungs results together points new paradigm role dna damage repair ogg aging age associated disease processes elsevier ireland ltd rights reserved
building integrated photovoltaic bipv technology immerging area recent development high potential implemented urban areas panels bipv system serve structural elements required fixed optimum tilt angle maximum insolation open fields obstructions hdkr hay davies klucher reindl model employed effectively calculating optimum tilt angle urban areas required consider adverse effect shading sky view blocking building accurate calculation optimum tilt angle determining maximum insolation attempt calculate optimum tilt angle bipv panel surrounded buildings different heights located different radial distances panel employing modified hdkr model present mathematical model gives accurate insolation values accounts shading sky view blocking effects sky view blocking effect expressed factor calculated integrating sky trapped curve plotted given tilt angle panel optimum tilt angle insolation bipv panel presented different state capital india considering shadow effect surrounding buildings elsevier ltd rights reserved
autoimmune pancreatitis aip occurring association inflammatory bowel disease ibd rather rare carries worse prognosis greater disease severity compared ibd alone although infrequently documented association progress last years led better understanding association aip ibd ibd stronger association type type aip clinical histologic features aip ibd often reveal features type aip imaging helpful facilitating diagnosis aip ibd similarly attempts identify serological marker yielded better result proposed lymphocyte homing mechanism provides insight mechanism pathogenesis review represents update current knowledge association aip ibd
wide range factors associated induction autism invariably linked either inflammation oxidative stress sometimes use acetaminophen babies young children may much strongly associated autism use pregnancy perhaps well known deficiencies metabolic breakdown pharmaceuticals early development thus one explanation increased prevalence autism increased exposure acetaminophen exacerbated inflammation oxidative stress neurotoxic babies small children view mandates extreme urgency probing long term effects acetaminophen use babies possibility many cases infantile autism may actually induced acetaminophen exposure shortly birth
species clusia genus shown important biomedical properties including ability inhibit tumor growth vitro usefulness skin care study examined cytotoxic effect hexane ethyl acetate methanol extracts clusia latipes planch triana clusiaceae leaves survival human prostate cancer cells colon cancer cells rko astrocytoma cells breast cancer cells mcf ethyl acetate extract displayed substantial cytotoxic effect however using comet assay observed hexane extract induced genotoxic effect dna damage human lymphocytes vitro model chromatographic purification latipes hexane extract led isolation identification friedelin friedolan hesperidin active cytotoxic compounds hexane extract beta amyrine identified active cytotoxic compound ethyl acetate extract latipes thereby supporting studies molecular mechanisms underlying effect secondary metabolites cancer cell survival sociedade brasileira farmacognosia published elsevier editora ltda rights reserved
agricultural expansion intensification main drivers land use change brazil soybean major crop expansion area soybean production involves large amounts water fertiliser act sources contamination potentially negative impacts adjacent water bodies impacts might intensified projected climate change tropical areas water footprint assessment wfa serves tool assess environmental impacts water fertiliser use aim study understand potential impacts environmental sustainability agricultural intensification close protected forest area amazon climate change carried wfa calculate water footprint related soybean production glycine max understand sustainability tapajos river basin region brazilian amazon large expansion intensification soybean based global datasets environmental hotspots potentially unsustainable areas identified spatially plotted baseline scenario projection use land use change scenario includes climate change effects results show green grey values increased respectively one third watersheds doubled grey soybean production lies within sustainability imits however current soybean expansion intensification trends lead large impacts relation water pollution water use affecting protected areas areas impacted terms water pollution dropped whole catchment unsustainability increased management practices water consumption regulations stimulate efficient water use reduction crop water use evapotranspiration optimal fertiliser application control could key factors achieving sustainability wilhin river basin elsevier rights reserved
non spherical particles known orient preferentially near wall turbulence rod like disk like particles align differently relative mean vorticity direction uncover mechanism gives rise preferential particle orientations anisotropic turbulence lagrangian statistics channelflow simulation analysed fluid mech vol showed fluid vorticity long rods independently aligned lagrangian fluid stretching direction isotropic turbulence following approach deduced left cauchy green strain tensor along lagrangian trajectories tracer spheroids channel flow turbulence results showed alignment fluid vorticity vector strongest lagrangian stretching direction channel centre isotropic turbulence vanished vicinity walls analysis revealed directions strongest lagrangian stretching compression near wall turbulence streamwise wall normal directions respectively channel found symmetry axis prolate spheroids aligned direction strongest lagrangian stretching whereas oblate spheroids oriented direction lagrangian compression finding apparently universal since trends found highly anisotropic wall turbulence well isotropic turbulence contrary prevailing view shown first time preferential orientation symmetry axis long rods streamwise direction flat disks wall normal direction caused lagrangian stretching fluid rotation finding fills gap understanding orientation rotation tracer spheroids anisotropic wall turbulence
camera objectives laser focusing units consist complex lens systems multiple lenses optical performance complex lens systems dependent correct positioning lenses system deviations location angle within system directly affect achievable image quality optimize achievable performance lens systems errors corrected machining mount lens respect optical axis innolite gmbh opto alignment technology developed novel machine center turning operation confocal laser reflection measurement sensor determines absolute position optical axis reference spindle axis strong advantage compared autocollimator measurements utilized opto alignment sensor capable performing centration tilt measurements without changing objectives radius surface infinity lens diameters including cylinder aspheric parabolic surfaces addition performs significantly better coated lenses optical axis skewed offset reference spindle axis determined measurement using information mount reference surfaces machine program untrue turning process calculated data fully automated manner since optical axis collinear spindle axis diamond tool compensates linear tilt deviations small correction movements results simple machine setup control system works electronic alignment chuck remaining eccentricity angular errors sec typical alignment results
theoretical analysis optimization optoelectronic receiving chain pulsed laser tracking systems presented optical receiver electronics analog signal processing measure angle displacements optical axis receiver direction optical receiver designated object based current signals generated avalanche quadrant photodiode considering minimum allowed angle measurement error optimal optical receiver aperture diameter optimal size avalanche quadrant photodiode maximal range system estimated
background human immunodeficiency virus hiv associated cognitive impairment loneliness associated cognitive decline old age older black adults hiv may particular risk loneliness due stigma lack social resources objective tested hypotheses older black adults hiv would show greater loneliness older white adults hiv greater loneliness among older black adults hiv would associated poorer cognitive function methods total participants hiv without hiv mean age years standard deviation years mean education years standard deviation years male black community based cross sectional study rush center excellence disparities hiv aging cedha completed item self report scale used measure emotional loneliness battery cognitive measures results contrary expectations older black adults indicated less overall loneliness white adults beta models controlling effects age education sex global cognition income however models cognitive function outcome interaction race loneliness observed older black adults indicated greater loneliness showed poorer cognitive function relative white adults beta conclusion older black adults hiv reported less loneliness older white adults however inverse association loneliness cognitive function stronger black white older adults additional work needed elucidate mechanisms underlying interaction karger basel
social factors influence drug abuse conversely drugs abuse alter social behavior especially pertinent post weaning development profound changes social repertoire sensitivity positive negative effects drugs abuse altered study aimed provide overview current understanding interaction drugs abuse juvenile adolescent social behavior first provide evidence characteristic form juvenile adolescent social behavior social play behavior reinforcing properties affected drugs abuse next social risk factors drug use addiction described including antisocial personality traits early social insults last discuss research investigates social influences drug use well consequences perinatal drug exposure later social interactions social play behavior highly rewarding laboratory animals affected low doses opioids cannabinoids ethanol nicotine psychostimulants humans antisocial personality traits prominently form conduct disorder prominent risk factor drug addiction preclinical studies consistently shown altered sensitivity drugs result social isolation post weaning development social environment individual profound complex influence drug use perinatal drug exposure markedly alters later social interactions studies reviewed provide framework understand interaction drugs abuse adolescent social interaction preclinical clinical level
paper presents new proportionate normalized subband adaptive filter pnsaf algorithm called iaf pnsaf assigns individual activation factor filter coefficient instead common one filter coefficients standard pnsaf algorithm algorithm achieves improved performance terms convergence rate tracking capability identifying highly sparse system moreover overcome trade fixed step size iaf pnsaf algorithm fast convergence rate small steady state misalignment adaptive combination version proposed simulation results identifying impulse response high sparseness demonstrated proposed algorithms outperform counterparts
shrink electrical circuits beyond looming practical limits moore law common goal create carbon based components first example new class donor sigma acceptor rectifiers hemibiquinones hbqs hbqs possess donor acceptor moieties electronically isolated inter ring torsion hbq dinitrile self assembles template stripped gold surface directed chemisorption forming thick monolayer rectification measured monolayer single molecules using three different top electrode arrangements even though hbqs composed relatively weak electrophores rectification ratios ranging observed
using data family module east asian social survey article examines associations marital satisfaction divisions housework gender ideology four east asian societies urban china japan south korea taiwan compared japanese korean married women men chinese taiwanese spouses satisfied marriage egalitarian divisions housework simultaneously held less egalitarian gender ideologies multivariate analyses showed relative share housework negatively associated marital satisfaction japanese korean men korean taiwanese women egalitarian gender ideology significantly associated lower marital satisfaction among taiwanese women addition negative association housework marital satisfaction pronounced taiwanese women espoused egalitarian gender ideologies authors discuss differences macro level social contexts explain cross society variations
measurement bone turnover markers alternative way determine effects exercise bone health week group based step aerobics exercise significantly improved functional fitness postmenopausal women low bone mass showed positive trend reducing resorption activity via bone turnover markers major goal study determine effects short term group based step aerobics gbsa exercise bone metabolism bone mineral density bmd functional fitness postmenopausal women pmw low bone mass forty eight pmw aged years low bone mass lumbar spine bmd score recruited randomly assigned exercise group control group participants attended progressive week gbsa exercise intensity heart rate reserve min per session three sessions per week serum bone metabolic markers terminal telopeptide type collagen ctx osteocalcin bmd functional fitness components measured training program mixed models repeated measures method used compare differences groups alpha week intervention period significant exercise program time interaction ctx however percent change ctx significantly different groups significant change osteocalcin groups expected significant change bmd groups addition functional fitness components significantly improved demonstrated substantial enhancement lower upper limb muscular strength cardiovascular endurance current short term gbsa exercise benefited bone metabolism general health significantly reduced bone resorption activity improved functional fitness pmw low bone mass suggested gbsa could adopted form group based exercise senior community
enhanced nonstationary buffeting force model calculating tropical storm typhoon hurricane induced buffeting response long span bridges presented evolutionary power spectral density epsd existing nonstationary tropical storm wind model first revisited enhanced taking consideration recently proposed typhoon turbulence spectra coherence transfer function matrix time dependent aerodynamic admittance function introduced eliminate strip quasi steady theory assumptions way implementing wind tunnel measured span wise chord wise coherence aerodynamic forces finally non linearity buffeting forces resulting variations instant effective angle attack nonuniform span wise profile mean wind speed considered enhanced model influence aforementioned enhancements nonstationary buffeting force model tropical storm induced buffeting response long span bridges assessed example stonecutters bridge subjected typhoon dujuan results suggest enhanced epsd model tropical storm winds nonlinearity due instant effective angle attack variations velocity span wise profile slightly change buffeting responses however introduction span wise coherence buffeting forces increases nonstationary extreme responses time dependent admittance function reduces extreme responses much american society civil engineers
access distributed web applications computer network mobile agents long proved successful tool power mobile agent lies migrating destination hosts directly retrieving information consideration since many businesses run sensitive data distributed servers mandatory demand information downloaded mobile agents need authenticated authorized provide authentication digital signatures based well known algorithms rsa ecc proposed past main drawback works computationally efficient encryption decryption keys used encrypt decrypt content thus major contribution work reduce computational complexity authentication mobile agents new hierarchical access management scheme computational costs reduced key derivation signature verification processes proposed work reduces computational time provides flexibility give fine grained access mobile agents access authorized files extensive simulations prove approach significantly reduces computational overhead recent works literature hence approach best suited implementation distributed web environments
background ghrelin levels obestatin ghrelin ratio proposed activity markers ulcerative colitis data available celiac disease irritable bowel syndrome ibs aims follows assess obestatin ghrelin concentrations adult active patients diarrhea predominant ibs ibs healthy controls relation intestinal permeability evaluate ghrelin obestatin profile patients year gluten free diet gfd establish impact ghrelin genetics methods study included patients ibs patients intestinal permeability assayed high performance liquid chromatography determination urinary lactulose mannitol circulating concentrations obestatin ghrelin ratio evaluated enrollment gfd ghrelin single nucleotide polymorphisms arggln leumet glnleu analyzed results intestinal permeability impaired patients ameliorated gfd ghrelin significantly higher obestatin ghrelin ratio significantly lower patients compared ibs gfd reduced peptide levels without reaching concentrations significant differences found leumet polymorphism among groups reduction genotype allele ibs patients compared conclusion intestinal permeability altered ibs patients ghrelin levels increase patients observed inflammatory conditions moreover role ghrelin genetics hypothesized sustaining many pathogenetic components different pathologies similar symptom profile copyright wolters kluwer health inc rights reserved
paper consider balancing problem hierarchical market based structure smart energy grids based universal smart energy framework large scale introduction renewable intermittent energy sources power system create mismatch forecasted day ahead actual supply demand without proper control strategy deviation could lead network overloads commercial losses present multilevel distributed optimal control formulation problem appliances prosumers provide flexibility optimally dispatched based local information control strategy takes capacity limitations distribution network account provide example simulation results obtained distributed model predictive control
stone columns proved useful technique supporting flexible structures resting soft soils however case soft soils stone columns encountered excessive settlements due insufficient lateral resistance offered soft soil bulging columns upon loading bulging may reduced great extent reinforcing columns either encasing geosynthetics placing horizontal circular discs geosynthetics within columns regular interval present study model tests carried long floating end bearing single groups columns without reinforcement evaluate relative improvement failure stress composite ground due different types reinforcement exhumed deformed column shapes used understand failure mechanism different types configurations reinforcement geogrid best geosynthetic type encasement end bearing columns floating columns geotextile geogrid equally good horizontal circular discs encasement configurations
used retrospective data mining approach explore association serum amiodarone amd desethylamiodarone dea concentrations thyroid related hormone levels laboratory data sets january april extracted computerized hospital information system database national cerebral cardiovascular center ncvc data sets contained serum amd dea concentrations thyroid function tests including thyroid stimulating hormone tsh free thyroxine free triiodothyronine analyzed total clinical laboratory data sets patients analyzed data sets classified five groups euthyroidism hyperthyroidism subclinical hyperthyroidism hypothyroidism subclinical hypothyroidism based definition thyroid function hospital abnormal levels thyroid hormones observed within therapeutic range serum amd dea concentrations mean dea amd ratio hyperthyroidism group significantly higher euthyroidism group mean dea amd ratio hypothyroidism group significantly lower euthyroidism group suppressed tsh group elevated level group showed significantly higher dea amd ratios compared normal level groups elevated tsh group showed significantly lower dea amd ratio compared normal group high low dea amd ratios associated amd induced hyperthyroidism hypothyroidism respectively dea amd ratio may predictive marker amd induced thyroid dysfunction
occupational stress known health risk range psychological behavioral medical disorders diseases organizations individuals mitigate disorders preventive stress management enhanced wellbeing article addresses first known health risk evidence related occupational stress second use preventive stress management organizations framework intervention third emerging domain enhancing wellbeing strengthens individual premature death disability along chronic suffering occupational stress inevitable despite known outcome risks
since thermal environment affects production egg quality laying hens mortality rates highly relevant control thermal environment within poultry houses best financial profits could obtained three commercial poultry houses different climatization systems analyzed current research poultry house tunnel like ventilation pad cooling poultry house natural ventilation nebulization poultry house simple natural ventilation thermal environment production egg quality laying hens mortality rates among different poultry houses different areas poultry house compared economic profits based difference electric energy consumption climatization systems laying hens productivity poultry house calculated electricity meters installed within electrical circuits climatization light systems three poultry houses data registered december march results showed poultry houses featured heterogeneity internal thermal environment faults climatization systems important differences reported egg production quality caused overheating poultry house tunnel like ventilation pad cooling best thermal isolation external environment resulted improvement production decrease laying hens mortality rates best economic result
background aimed evaluate efficacy five oral nucleos ide analogues nas including lamivudine entecavir adefovir telbivudine tenofovir prevention hepatitis virus hbv reactivation hbv related complications chronic hepatitis virus chb infected patients hematological malignancies receiving chemotherapy hematopoietic stem cell transplantation hsct network meta analysis methods search identified articles involving different prophylactic regimens covering participants results among five prophylactic regimes tenofovir predicted probability effective intervention followed entecavir preventing hbv reactivation significant difference tenofovir entecavir preventing hbv reactivation regards outcomes tenofovir telbivudine included evaluate due lack relevant studies entecavir effective intervention reducing risk hbv related hepatitis hbv related death causes hepatitis conclusion tenofovir entecavir might potent regimes prevention hbv reactivation chb infected patients hematological malignancies undergoing chemotherapy hsct
paper studies notations students family gender roles feminine stereotypes prevailingly established masculinity young men less expressed ideas roles women men viewpoint girls young men respectively collected girls priority career family ascertained well main motive creation family important qualities based ideas roles responsibilities life partner future husband girls important criteria choice life partners thought system diligence maturity ability provide protect family confidence maintaining healthy lifestyle lack addictions students also noted need emotional contact spouses future children well consciousness importance husband head family research able obtain data indicating immaturity ideas family structures gender roles students entertained possibility combination domestic duties child rearing career growth others preferred career family students tendency dominate dictate dish orders others shown coupled instability character difficult situations preferred rely opinion decision spouse study subjects youths displayed low indicators readiness marriage understood marriage emotional journey overestimated romanticism subjects lacked major psychological household skills needed marriage majority students interested marriage plans get married nearest future published future academy www futureacademy org
magnetically controlled shape memory alloys new kind smart material used microdisplacement micropositioning applications however hysteresis nonlinearity material obstacle achieving high precision accuracy describe hysteresis nonlinearity modeling method based proportional integral differential pid neural network proposed using backpropagation training algorithms train weights model better approximate main minor hysteresis loops adding nonlinear function input layer simulation results show maximum prediction error pid neural network model given input signal results major hysteresis loop maximum prediction error pid neural network model given input signal results major minor hysteresis loops error calculations demonstrate effectiveness modeling method
created easy use device operant licking experiments another device records environmental variables devices use raspberry computer obtain data multiple input devices radio frequency identification tag readers touch motion sensors environmental sensors activate output devices led lights syringe pumps needed data gathered devices stored locally computer automatically transferred remote server via wireless network tested operant device training rats obtain either sucrose water control fixed ratio variable ratio progressive ratio reinforcement schedule lick data demonstrated device sufficient precision time resolution record fast licking behavior rats data environment monitoring device also showed reliable measurements providing source code design open source license believe examples stimulate innovation behavioral studies
objective study estimate whether maternal history childhood maltreatment associated pre pregnancy obesity excessive gestational weight gain pregnant women reported pre pregnancy weight height gestational weight gain followed years post partum reported maltreatment childhood trauma questionnaire ctq ctq score ranged maltreatment severe maltreatment prenatal mental health modified association ctq score maternal weight percentile state trait anxiety inventory relative risk confidence interval associated among less anxious percentile women risk excessive gestational weight gain higher adjusted every increase ctq score anxious women association observed less anxious women adjusted prenatal depression similarly modified association maltreatment weight gain factors psychological status traumatic experiences early childhood may contribute pre pregnancy obesity excessive gestational weight gain
clinical practice low molecular weight heparins used relatively frequently patients atrial fibrillation prevent embolic events article revised available evidence following clinical situations rapid onset anticoagulation bridging therapy replacing long term oral anticoagulant therapy around invasive procedure transesophageal echocardiography guided cardioversion elsevier espana sociedad espanola medicina interna semi rights reserved
vessel segmentation critical task various medical applications diagnosis assistance diabetic retinopathy quantification cerebral aneurysm growth guiding surgery neurosurgical procedures despite technology advances image segmentation existing methods still suffer low accuracy vessel segmentation two challenging common scenarios clinical usage regions low signal noise ratio snr vessel boundaries disturbed adjacent non vessel pixels paper present automated system achieve highly accurate vessel segmentation images even challenging scenarios three key contributions achieved system progressive contrast enhancement method adaptively enhance contrast challenging pixels otherwise indistinguishable boundary refinement method effectively improve segmentation accuracy vessel borders based canny edge detection content aware region interests roi adjustment method automatically determine locations sizes rois contain ambiguous pixels demand verification extensive evaluation method conducted datasets public retinal dataset named drive staal ieee trans med imaging clinical cerebral dataset approach achieves superior performance state art methods including vesselness based method frangi int conf medical image computing computer assisted intervention optimally oriented flux oof based method law chung european conf computer vision evaluation clinical cta cerebral datasets shows method achieve average accuracy respect manual segmentation reference better five baseline methods yushkevich neuroimage law chung european conf computer vision law chung ieee trans image process wang neurosci methods manually optimized parameters system also applied clinically cerebral aneurysm development analysis experimental results patients data two scans per patient show system automatic diagnosis outcomes consistent clinicians manual measurements
paper describes method fast identification thermal behavior vehicle integrated electric drives propose better understanding electric machine design tailored driving cycles simple satisfactorily accurate calculation method estimation machine losses input analytic thermal network early design stage introduced analytic models verified using measurement data used parameter case studies consideration thermal environment focus gearbox first case study analyzes influence gearbox thermal behavior critical machine components aiming use gearbox lubricant cooling winding heads improvement machine performance using alternative cooling approach cools end windings shown second case study
development new material designed trap heavy metals sediments wastewater based polypropylene non woven covalently grafted cysteine reported previous paper part non woven first functionalized acrylic acid used spacer cysteine immobilized substrate covalent coupling order obtain called cysteine preliminary heavy metals adsorption tests gave interesting results degrees heavy metals solution cysteine adsorbs cuso solution solution solution solution second part work heavy metals sorption tests carried iii separately order determine sorption capacity new sorbent function heavy metals concentration solution contact time solution iii ionic strength solution containing heavy metals moreover sorption capacity cysteine studied using polluted solution consisting mixture different heavy metals electron paramagnetic resonance study finally carried order determine coordination geometry environment copper trapped cysteine elsevier ltd rights reserved
point cloud fundamental representation three dimensional geometric objects analyzing processing point cloud surfaces important computer graphics computer vision however existing algorithms surface analysis require connectivity information therefore desirable develop mesh structure point clouds task simplified aid parameterization particular conformal parameterizations advantageous preserving geometric information point cloud data paper extend state art spherical conformal parameterization algorithm genus closed meshes case point clouds using improved approximation laplace beltrami operator data points propose iterative scheme called north south reiteration achieving spherical conformal parameterization balancing scheme introduced enhance distribution spherical parameterization high quality triangulations quadrangulations built point clouds aid parameterizations also meshes generated guaranteed genus closed meshes moreover using proposed spherical conformal parameterization multilevel representations point clouds easily constructed experimental results demonstrate effectiveness proposed framework
pulmonary vein thrombosis pvt rarely encountered disease entity varied clinical presentations usually associated lung carcinoma lung surgeries complication radiofrequency catheter ablation procedure atrial fibrillation clinical manifestations vary mild hemoptysis lung infarction hemodynamic compromise year old male presented history pleuritic left sided chest pain past medical history included polycythemia vera atrial fibrillation coronary artery disease pulmonary embolism pulmonary hypertension chest radiograph normal troponins normal lead electrocardiogram show ischemic changes computerized tomography pulmonary angiogram revealed filling defect left lower lobe pulmonary vein treated subcutaneous enoxaparin symptoms improved case highlights rare etiology chest pain first reported case association polycythemia vera pulmonary vein thrombosis high index suspicion required appropriate diagnostic work pvt mimic pulmonary embolism diagnostic work treatment strategies depend acuity presentation
order comply new requirement personnel training transformation local universities applied technological universities article associate teaching practice changsha university aims promoting teaching reform updating teaching methods strengthening practical teaching changing testing methods reforms successfully mobilized enthusiasm initiative students obtained preliminary results
aim study develop evaluate stability cosmetic formulations containing botanical extracts acai chamomile green tea promising adjuvants cosmetic preparations extracts previously submitted photostability antioxidant activity studies antioxidant activity determined chemiluminescence total phenolic content folin ciocalteu method photostability extracts also determined formulations developed experimental formulations prepared containing extracts acai chamomile green tea submitted accelerated stability studies determination rheological properties sensorial analysis results showed extracts potential antioxidant effect green tea promising one highest total phenolic content may explain difference observed formulation containing green tea extract also showed best performance sensorial analysis concluded extracts seem promising properties use cosmetic formulations green tea extract however significant performance studies published elsevier
building construction maintenance one major contributors global warming result potential leader sustainable development scaffolding systems important component building construction especially high rise buildings scaffold consists modular system metal bamboo tubes pipes scaffolding temporary construction structure created reaching heights human reach purpose helping construction maintenance structure scaffolding industry dominated steel areas bamboo indigenous like many east asian cities bamboo scaffolding material choice even comes high rise buildings goal analyze bamboo steel thoroughly establish environmental impacts using life cycle analysis lca consequently study explores ecological viability expanding use bamboo scaffolding steel predominates functional units used study bamboo steel scaffolding systems high wide deep cradle gate lca performed evaluate environmental performance two scaffolding systems results suggest bamboo scaffolding lower carbon footprint steel scaffolding ability sequester carbon growth phase significant contributing factor important advantage bamboo nonrenewable materials steel additionally bamboo functions buffer delaying release use phase main challenge scaffolding system made renewable materials western world demand standardization therefore ideal future goal design standardized scaffolding systems using renewable materials combines durability homogeneity steel scaffolding sustainability environmental performance bamboo scaffolding
suicidal behavior among military personnel persists significant public health issue previous research indicates primary motive suicide attempts among military personnel desire reduce alleviate emotional distress finding converges studies nonmilitary samples much less understood consequences first suicide attempt could influence occurrence additional suicide attempts order identify contingencies active duty soldiers attempted suicide first time attempters multiple attempters participated structured interviews focused experiences immediately following first attempt soldiers likely made multiple suicide attempts younger time first attempt admitted hospital treatment program first attempt experienced emotional psychological relief immediately afterwards results suggest soldiers experience emotional psychological relief immediately first suicide attempt receive treatment likely make additional suicide attempts elsevier ireland ltd rights reserved
population level little known regarding risk liver nonliver related mortality hospitalization development hepatocellular carcinoma hcc hepatitis virus hcv infected patients decompensated cirrhosis large scale national record linkage study estimates outcomes following first hospital admission record linkages national hcv diagnosis clinical databases national inpatient hospital episode database mortality register conducted follow disease course identified hcv diagnosed chronically infected persons study population consisted hcv chronically infected persons first hospital admission within period observed overall average annual percentage change new patients evidence improvement relative risks liver related cause death time january may patients died liver nonliver related cause respectively patients subsequent first admission hcc year cumulative incidence liver related mortality nonliver related mortality first subsequent hcc admission respectively health burden hcv infected patients associated development decompensated cirrhosis increased dramatically last years findings establish baseline mortality hcc progression rates patients impact new antiviral therapies measured
two inter related studies examined effect september terrorist attacks attitudes towards war violence three wave subjects analysis revealed attitudes towards war became positive september remained high year afterwards self reported trait physical aggression also rose september attitudes towards penal code violence pcv became positive immediately september somewhat reduced year afterward two wave within subjects study revealed war attitudes became even positive months post september attitudes towards pcv became less positive time period women aggression related attitudes affected either study studies demonstrate large scale event change attitudes attitudes must directly relevant event
empathy widely recognized psychological foundation prosocial behavior yet little known methods increase affective empathy students trainees present research sought assess reliability potential boundary conditions one intervention brief emotional video featuring boy diagnosed cancer study found video succeeded indirectly increasing empathic concern african american victim police abuse among ethnically diverse student sample classroom setting study replicated effect online environment among population near racially homogeneous adults effect brief convenient positive affect intervention line practice based negative affect interventions
electricity generation moving currents without using dams stream hydrokinetic electricity potential introduce multiple renewable power grids study evaluates control system designed regulate generator rotor rate rpm improve power production stream hydrokinetic turbines control algorithm evaluated using numerical models rigidly mounted tidal turbine moored ocean current turbine oct coupled induction electric machine model moored simulation utilizes innovative approach coupling multiple degrees freedom dof nonlinear hydrodynamic mechanical turbine model nonlinear electromechanical generator model based turbine torque speed characteristic well asynchronous machine features proportional integral controller used generate correction term frequency three phase sinusoidal voltages supplied asynchronous generator speed control induction generator supply frequency accomplished simplified voltage source inverter vsi simplified vsi consists control voltage sources cvss comparison real vsi using diodes transistors controlled pulse width modulation pwm technique also presented simulations used evaluate developed algorithms showing rpm fluctuations around tidal turbine operating wave field significant wave height around moored ocean current turbine operating wave field significant wave height
paper compares field response two test embankments constructed similar soft soil deposits strengthened foundation vertical drains underneath embankment strengthened foundation geotextile encased granular columns provided basal geogrid reinforcement effectiveness encased granular columns assessed comparing settlement embankments horizontal displacement soft foundation excess pore pressures middle soft clay layer results showed granular encased columns significantly reduced maximum settlement occurring embankment well maximum horizontal displacement clayey foundation settlement level load carrying capacity strengthened foundation found increase much around times strengthened one also observed geotextile encased granular columns caused noticeable reduction maximum excess pore pressure following load application furthermore degree consolidation achieved end embankment construction quite high encased granular columns used
understanding sources chemical components roof runoff help prevent water quality problems rooftop rainwater harvesting identify contribution wet deposition mass components roof runoff samples air rainwater dust buildup roof runoff collected urban site shenzhen china results indicate wet deposition dominant contribution mass total organic carbon toc organic acids roof runoff mass acetic acid formic acid roof runoff may greatly reduced neutralization components alkaline dust buildup rooftop wet deposition partially contributes mass roof runoff factors like dust buildup rooftop chemical reactions also non negligible impact furthermore toc organic acids wet deposition mainly influenced atmospheric pollution due fast increase fossil fuel consumption vehicle emissions therefore effects wet deposition carefully considered rooftop rainwater harvesting urbanized areas
demonstrated people suffering substance related addictions less empathic non addicted counterparts first aim verify also true behavioral addictions hypothesized problem gamblers less empathic healthy controls second aim identify cognitive marker empathy could targeted cognitive rehabilitation strategies propose potential cognitive marker empathy could visuospatial perspective taking specifically hypothesized visuospatial perspective taking performances lower problem gamblers compared healthy controls visuospatial performances predict empathy thirty one non gamblers healthy gamblers problem gamblers performed visuospatial perspective taking task completing interpersonal reactivity index iri davis davis problem gamblers decreased empathy lower performance visuospatial perspective taking task non gamblers healthy gamblers furthermore confirmed visuospatial perspective taking abilities predict empathy iri dimensions interpersonal perspective taking personal distress present study provides new evidence reduced empathy limited subjects substance related addictions rather extends behavioral addictions visuospatial perspective taking may viable cognitive marker use rehabilitation target empathy
one robust laws memory repeated activation improves memory study shows nature repetition matters specifically although negated repetition affirmative repetition improve memory compared repetition negated repetition hinders memory compared affirmative repetition showing participants different entities asked features entities leading either yes responses findings show correctly negating incorrect feature entity elicits active forgetting effect compared correctly affirming true features example seeing someone drink glass white wine answering red wine may lead one greater memory loss individual drinking wine compared answering yes white wine find negation induced forgetting effect experiments differ meaning given negation type stimuli visual verbal memory measure recognition free recall discuss possible underlying mechanisms offer theoretical applied implications negation induced forgetting effect relation known inhibition effects
paper dynamic linear model suspension bridge center spans formulated three different ways fixing main cables studied model describes vertical torsional oscillations deck action lateral wind mutual interactions main cables center span hangers analyzed three variational evolutions analyzed variational equations correspond way main cables fixed existence uniqueness continuous dependence data proved
cancers diagnosed children age years represent cancer cases survival childhood cancer greatly improved past years high income countries study aims estimate number people living italy childhood cancer cancers combined selection cancer types computed year prevalence using data italian population based cancer registries covering italian population estimated complete prevalence italy using childprev method implemented comprev software total persons alive january cancer diagnosed childhood number corresponds proportion per italians prevalent cases among males survived diagnosed start observation period quarter childhood prevalent cases diagnosed brain central nervous system tumors quarter acute lymphoid leukemia hodgkin lymphoma nearly quarter prevalent patients aged years older information number people living childhood cancer italy cancer type specific health care needs may helpful health care planners clinicians development guidelines aimed reduce burden late effect treatments childhood new number long term childhood cancer survivors expected increase due improved treatments treatments may long term effects study authors developed methodology estimate total number proportion people living particular country age surviving childhood cancer estimates may help health care planners clinicians develop specific guidelines aimed reducing burden late effect treatments received childhood
present results obtained using evolution cuda based solution exploration via breadth first search large graphs latest version exploits best features kepler architecture relies combination techniques reduce number communications among gpus amount exchanged data final result code visit billion edges second using cluster equipped tesla gpus
numerous policies proposed local state national level restrict youth access violent video computer games although studies cited support policies published research children perceive uses influence violent interactive games authors conduct focus groups boys ages boys use games experience fantasies power fame explore master perceive exciting realistic environments distinct real life work angry feelings relieve stress social tools boys believe harmed violent games concerned younger children might imitate game behavior especially swearing
aim paper propose solution model adequacy verification indirect adaptive control beside classical known validation tests dynamic system selected verify proposed solution represented flexible transmission described complex four order model using selected model adequacy index studied influence spab signal perturbation amplitude model adequacy control solution two different tracking performances selections proposed solution comes overcome model validation problems encountered real time applications main advantage improving model identification control solutions
fresh water renewable limited resource scarce many areas developing world paper proposes dual water supply consisting rainwater groundwater provide sustainable water arsenic contaminated area paper novel model developed based rainfall variance rainwater harvesting rwh system obtain optimal performance changing demand water use according rainfall model used design rwh system cukhe village using rainwater potable purposes dry days purposes rainy days recommended cost rwh systems also analyzed order achieve reliability four member household rwh system roof area additionally tank size recommended overall cost efficiency yearly water supply chart recommended rainwater supplied potable purposes january april october december supplied purposes may september
daily practice apophyseal avulsions sportive adolescents frequently diagnosed time delay treated heterogeneously using actual literature experience current diagnostic therapeutic strategies put perspective regards needs adolescent athlete apophyseal lesions hip area adolescence separated pelvis proximal femur reviewed according frequency relevance using updated literature treatment methods reported focus degree dislocation level sports activity frequent apophyseal avulsion pelvis avulsion tuber ischiadicum followed inferior anterior iliac spine superior anterior iliac spine apophysis ilium affected structure proximal femur lesser trochanter lesions greater trochanter rare cause injury specific acute contracture muscle inserting affected apophysis different sporting activities treatment pelvic apophyseal injuries surgical cases considerable fragment dislocation high level athletes femoral side patients treated almost always conservatively despite modern efficient osteosynthetic techniques treatment avulsion lesions hip region mainly conservative even athletes applying consequent diagnostic therapeutic principles development pseudarthroses heteropic ossifications minimised
climate change improper use water resources surface waters pollution well increase water requirements results growing population people world causes water deficiency majority countries world including poland due water pollution advanced technologies treatment demand leads increase water price connection often taken actions reduce water consumption using rainwater flush toilets wash cars laundry water green areas publication presents results life cycle cost analysis two variants water supply systems designed multi family residential building situated rzeszow line lcc methodology calculations made throughout whole life cycle building considering initial investment outlays intended construction water supply system well operation maintenance costs first analyzed variants assumed system would fed municipal water supply network second variant rainwater harvesting system domestic use additionally applied rainwater stored tank would used sanitary installation flush toilets leads lowering costs municipal water purchase reducing fees rainwater discharge sewage system consequently beneficial financial standing examined building
demographic aging worldwide phenomenon cognitive behavioral impairment becoming global burden nerve damage however effect pharmacological treatment satisfying therefore analyzed efficacy music therapy elderly dementia patients whether music therapy used first line non pharmacological treatment comprehensive literature search performed pubmed embase cochrane library inception september total studies analyses subjects included acceptable quality based pedro casp scale scores studies based type dementia patient combined analyzed subgroup standardized mean difference disruptive behavior cognitive function primary outcomes random effect models using controls comparator secondary outcomes depressive score anxiety quality life evidence publication bias found based begg egger test meta analysis confirmed baseline differences two groups balanced subgroup analyses showed disease sub type intervention method comparator subject location trial design trial period outcome measure instrument made little difference outcomes meta regression may identified causes heterogeneity intervention method comparator trial design music therapy effective patients received interactive therapy compared group positive evidence support use music therapy treat disruptive behavior anxiety positive trends supporting use music therapy treatment cognitive function depression quality life elsevier rights reserved
threats masculinity trigger compensatory mechanisms risk taking aggression disparagement gender atypical others study tested whether threat men agentic self information level testosterone influences men attitudes toward parental duties support gender equality polish men women whose gender identity threatened manifested traditional attitudes toward parental duties willing endorse stereotypical gender roles showed less support gender equality less willingness support collective egalitarian actions study found agency related gender system justification men suggesting potential mediator effects related compensatory mechanisms evoked gender identity threat among men confirmed study participants read short scientific text either emphasizing existence stereotypical gender differences terms agency communality claiming differences results indicated differences condition men women showed lower acceptance gender inequality greater willingness engage domestic activities effect mediated participants self perceived agency
paper use discrete transmission line model known geophysicists layered earth model derive several computationally efficient solutions following three problems well known hessenberg matrix capturing recurrence relations szego polynomials differs unitary last column hence first problem rapidly evaluate eigenvectors almost unitary hessenberg matrix second problem design fast algorithm inversion szego vandermonde matrices generalizing well known traub algorithm inversion usual vandermonde matrices iii finally third problem extend well known horner rule evaluate polynomial represented basis szego polynomials shall see three problems closely related solutions computed family fast algorithms although results derived algebraically reveal connection system theory deduce algorithms via elementary operations signal flow graphs digital filter structures including celebrated markel gray filter widely used speech processing certain filter structures choice clarifies derivation suggests variety possible computational schemes also makes interesting connection many results related szego polynomials already interpreted via signal flow graphs generalized lattice filter structures including formulas gohberg semencul type inversion toeplitz like matrices schur type levinson type algorithms etc example connection allows show moment matrices corresponding called horner szego polynomials though toeplitz quasi toeplitz certain shift invariance property elsevier science inc rights reserved
background estimated million school children participate sports united states middle school participants become injured seek medical treatment annual cost close billion purpose current study evaluate injury incidence rates female athletes middle school setting course seasons methods female basketball soccer volleyball players recruited single county public school district kentucky consisting middle schools total female athletes basketball soccer volleyball participated athletes monitored sports related injury number athlete exposures aes athletic trainer injury rates calculated specific types injuries within sport injury rates games practices also calculated compared sport results total injuries recorded sport seasons knee commonly injured body part injuries patellofemoral dysfunction osgood schlatter disease sinding larsen johansson patella tendinosis greatest incidence ankle second commonly injured body part accounting injuries overall rates injury sport follows soccer per aes volleyball per aes basketball per aes conclusions female middle school athletes displayed comparable injury patterns seen high school counterparts future work warranted determine potential improved outcomes female middle school athletes access athletic training services clinical relevance participation levels number injuries continue rise middle school athletes demonstrate increasing need medical services provided certified athletic trainer
research shown robust tendency people underestimate ability get others comply requests five studies demonstrate underestimation compliance effect reduced requesters offer money exchange compliance studies participants assigned incentive monetary incentive condition made actual requests others studies requesters offered incentives underestimated likelihood approached would grant requests however requesters offered monetary incentives prediction error mitigated studies present evidence support model explain underlying mechanism attenuation effect studies demonstrate offering monetary incentives activates money market frame study find activation reduces discomfort associated asking allowing requesters accurately assess size request consequently likelihood compliance elsevier inc rights reserved
nonverbal processes crucial parent child communication seldom focus therapeutic intervention child months age paper reviews literature nonverbal communication parent child interaction outline assessment tools interventions designed measure improve nonverbal communication identify gaps publications describing existing practice discuss implications intervention research development searched medline psycinfo databases theoretical empirical articles defined conceptualized measured intervened parent child nonverbal interaction although found number validated reliable assessment measures routinely used inform development interventions directly targeted nonverbal communication additionally identified interventions met established criteria evidence based practice directly focused nonverbal communication target change interventions included review utilized play creative arts mediums psycho education work therapeutically nonverbal processes given importance nonverbal communication effective parenting parent child communication recommend nonverbal communication assessed addressed explicitly core part parent child intervention development evaluation intervention development may additionally informed existing nonverbal assessment tools many already established good reliability validity therefore may assist intervention well outcome measurement
study aim identify mismatch industries requirement students perception towards entry level construction managers roles tasks total construction management students malaysian public universities uitm usm uthm participated study data collected using questionnaire analysed rasch model semi structure interview conducted verifying explaining quantitative result result study shows six eight similarities towards entry level construction managers roles task data semi structured interview clarify mismatch exist due lack exposure students internship construction company lack experience knowledge lead students misperception towards entry level construction managers roles tasks
ethnopharmacological relevance genus mitragyna rubiacaeae traditionally used parts africa asia oceania recent years increased interest species mitragyna introduction products western markets regulatory uncertainty aim study paper reviewed traditional ethnomedicinal uses leaves species belonging genus mitragyna reference botany known chemistry order highlight areas interest products currently sold kratom materials methods literature search conducted using web science google scholar royal museum central africa internet archive hathi trust biodiversity heritage library search engines spring fall winter document uses bark leaf root material results leaves speciosa kratom common documented ethnomedicinal uses opium substitute remedy addiction species mitragyna reportedly used treating pain however mode preparation often cited topical application uses mitragyna included treatment fever skin infections mild anxiolytic conclusions mitragyna species used medicinally various parts world significant traditional evidence use modern products include formulations topical application liniments balms tinctures may provide effective alternatives treatment certain types pains future research required establish safety toxicology limits medicinal chemistry parameters potential different physiological responses among varying genetic populations support regulatory requirements mitragyna spp
paper several kinds improved modes exhaust gas turbocharging egt investigated transient performances including steam assisted turbocharging sat electronically controlled turbocharging ect supercharger exhaust gas turbocharging set turbocharged gasoline engine employed study object conducted bench test firstly get basic data building calibrating simulation model accurate reliable power model steady transient engine operation developed basis transient processes four types engines egt engine set engine sat engine ect engine investigated simulation comparative analysis results show set sat ect reduce response time fuel consumption acceleration process response time various turbocharging approaches follows descending sequence egt sat ect set speed min idling full load compared egt engine specific fuel consumption sfc set engine decreased reduced sat engine ect engine respectively finally reveal improvement potentials sat ect matched larger turbine without wastegate results indicate torque thermal efficiency sat ect engines improved acceleration equilibrium time increased elsevier ltd rights reserved
background patients moderate severe atopic eczema often require photo systemic immunomodulatory therapies induce disease remission maintain long term control current evidence guide clinical management small despite frequent often label use treatments registries patients photo systemic immunomodulatory therapies could fill gap collection core set concerning therapies allow direct comparisons across registries well data sharing pooling using edelphi approach international treatment atopic eczema treat registry taskforce aims seek consensus key stakeholders internationally core set domains domain items patient registries research focus collect data children adults photo systemic immunomodulatory therapies methods design participants six stakeholder groups invited doctors nurses non clinical researchers patients well industry regulatory body representatives edelphi comprise three sequential online rounds requesting participants rate importance proposed domain domain items participants able add domains domain items proposed list round final consensus meeting held representatives stakeholder group discussion identifying uniform core set domains domain items captured patient registries increase utility individual registries provide greater insight effectiveness safety cost effectiveness photo systemic immunomodulatory therapies guide clinical management across dermatology centres country borders
vialactea project work package dedicated tools infrastructure inside task database virtual observatory infrastructure task aims providing infrastructure store resources needed purposely scientific work packages project infrastructure includes combination storage facilities relational databases web services top taken whole name vialactea knowledge base vlkb contribution illustrates current status vlkb details set data resources put together describes database allows data discovery inspired metadata maintenance illustrates discovery cutout access services built top former two users exploit data content
septo optic dysplasia sod morsier syndrome characterized optic nerve hypoplasia pituitary endocrine dysfunction midline brain abnormalities hypopituitarism hypothyroidism hypogonadism adrenal insufficiency lead severe hypoglycemia adrenal crisis seizures sudden death anesthetic management sod associated high perioperative mortality year old male child proposed dental treatments extractions medical history sod hypopituitarism hypothyroidism delayed psychomotor development observed anesthetic induction sevoflurane intravenous administration hydrocortisone plus dexamethasone given infusion glucose sodium chloride started anesthesia sevoflurane air combined local infiltration lidocaine maintained procedure patient breathing spontaneously hemodynamically stable normal glucose levels measured every min patient received paracetamol analgesia discharged hospital procedure without complications mortality related general anesthesia patients put challenges procedure imperative improving health quality life patient opted inhalational anesthesia combined local infiltration think combined anesthesia contributed abolition pain avoided adrenal suppression contributing success procedure
vaginal discharge common complaint managed nps ambulatory settings article reviews noninfectious etiologies vaginal discharge diagnostic criteria recommended treatment aid correctly managing patients
study measured incidence hip fractures tangshan china shows compared data reported tangshan crude incidence hip fractures increased females slightly decreased males however incidences age specific hip fracture females aged males aged increasing introduction purpose study assess incidence hip fractures tangshan china compare incidence previously reported tangshan methods data obtained hospitals within tangshan orthopedic department medical records radiographs patients sustained fractures reviewed absolute number admissions described incidence rates per individuals adjusted age years gender calculated based data tangshan population population tangshan determined males females results population years age represented total population included individuals males females cervical trochanteric fractures males females male female ratio overall incidence rate hip fractures fractures per men per year fractures per women per year females showed significantly higher incidence hip fractures males older groups youngest group males markedly higher incidence females compared incidence measured tangshan crude incidence hip fractures decreased males increased females age specific incidence increased male older age groups age specific incidence increased female older age groups decreased younger years conclusion compared results crude incidence hip fractures tangshan increased females slightly decreased males however age specific incidences hip fracture females aged males aged still increasing
bipolar disorder unique mood disorder defined periods depression mania defining diagnosis presence mania hypomania symptoms including hyperactivity risk taking since current treatments ameliorate cognitive deficits risky decision making impulsivity negatively affect patient quality life better treatments needed tested whether acute treatment brexpiprazole serotonin dopamine activity modulator partial agonist activity hta receptors would attenuate mania relevant behaviors dopamine transporter dat knockdown mouse model mania effects brexpiprazole dat knockdown wild type littermate mice examined behavioral pattern monitor bpm iowa gambling task igt quantify activity exploration impulsivity risk taking behavior respectively dat knockdown mice exhibited hyper exploratory behavior bpm made fewer safe choices igt brexpiprazole attenuated mania like hyper exploratory phenotype increased safe choices risk preferring dat knockdown mice brexpiprazole also reduced safe choices safe preferring mice irrespective genotype finally brexpiprazole reduced premature impulsive like responses groups mice consistent earlier reports dat knockdown mice exhibited hyper exploratory risk preferring impulsive like profiles consistent patients mania tasks behaviors attenuated brexpiprazole treatment data therefore indicate brexpiprazole could novel treatment mania risk taking impulsivity disorders since remediates relevant behavioral abnormalities mouse model
electric vehicle vehicle powered electric motor cases induction motors applied clearly increasing complexity electrical electronic architectures used electric vehicles possible generate fault conditions open circuits provide graceful degradation system performance three phase induction motor operate even one less phase avoid hard fail stop behaviors ensure continuity operation even presence fault conditions article proposes introduction multiphase voltage source inverter multiphase induction motor double star induction machine electric drain train controlled direct torque control open circuits fact using strategy control allows elimination torque ripples continuity service experimental results illustrate effectiveness proposed control scheme hydrogen energy publications llc published elsevier ltd rights reserved
anorexia nervosa serious psychiatric disorder typically occurs young women however cases middle aged women reported management complex disease requires team approach full recovery occurs patients endocrine metabolic complications commonly observed latter may even life threatening require prompt proper management infections albeit reported usually major clinical problem patients herein report case severely malnourished middle aged woman long standing hospitalized marked hypokalaemia meq rhabdomyolysis hospitalization developed septic shock acute respiratory distress syndrome required urgent admission intensive care unit underwent sedation tracheal intubation mechanical ventilation managed combined therapies eventually led successful outcome life threatening medical complications occur young women middle aged women well require combined multidisciplinary approach
improve availability software defined networking sdn distributed denial service ddos attacks multi queue sdn controller scheduling algorithm based time slice allocation strategy proposed proposed algorithm take different time slice allocation strategies according intensity ddos attacks use sdn controller schedule processing flow request different switches including switches suffering different degrees attacks normal switches ensure better protection normal switch network ddos attacks simulation results presented show effectiveness proposed algorithm
improved solution drug distribution presented paper divided two parts multi operator evolutionary algorithm charge calculating initial delivery routes ambient intelligence based support system able tracing merchandise along distribution route first one establishes routes followed vehicles based proposal estimation travel times second one formed system able recognize trace drugs inside vehicle laboratory experimentation conducted order demonstrate adequacy route calculator addition field experimentation carried implementing traceability system delivery van drug distributor city bilbao note practitioners motivated specific needs found drug distributor managing deliveries pharmacies involved supply chain paper considers optimization problem proper way model particularities found scenario paper proposes use combinatorial optimization problem way model problems due fact distributor clients located different cities proposal considers travel times cities inside city addition rush hours also taken account order provide realistic model finally radio frequency identification based solution proposed order implement traceability delivered products well prevent human errors additionally case unavoidable error occurs solution offers also incident management mechanism
kda protein redox active dithiol active site cys gly pro cys human thioredoxin trx demonstrated excellent anti inflammatory effect various animal models trx induced various oxidative stress factors including ultraviolet rays radiation oxidation viral infections ischemia reperfusion anticancer agents involved pathogenesis progression various diseases demonstrated systemic administration transgenic overexpression trx effective wide variety vivo inflammatory disease models viral pneumonia acute lung injury chronic obstructive pulmonary disease indomethacin induced gastric injury dermatitis recent studies indicate topically applied trx prevents skin inflammation via inhibition local formation inflammatory cytokines chemokines indicate activation inflammasome skin mucosa may regulated trx suggest application trx may useful treatment various skin mucosal inflammatory disorders based results conducting clinical studies develop human recombinant thioredoxin rhtrx pharmaceuticals also developed substances increase expression trx body trx inducing substances vegetables plant ingredients also developing skin care products functional foods take advantage anti inflammation anti allergic action trx elsevier inc rights reserved
study examined pathogenesis early onset sarcoidosis eos patient rare nod mutation surveyed literature identify hallmark features early diagnosis infant girl suffering prolonged fever skin rash multiple pinkish papules subsequent erythema nodosum referred institution skin biopsy dna sequencing performed along cytokine profiling patient serum stimulated mononuclear cells kappa activation analyzed using transfected cells multiple non caseating granuloma inclusions recognized biopsy specimens obtained patient rash dna sequencing revealed rare heterozygous metthr mutation nod mononuclear cells produced low amount beta upon stimulation compared normal control cells mutated nod transfection enhanced kappa activation suspected mutation nod decreased beta production enhanced kappa activation likely responsible patient granuloma involvement comprehensive review literature cases sporadic type eos revealed patients cutaneous manifestations one displaying granulation majority eos patients half sporadic eos nod mutations present case accordingly skin rash granuloma formation specific nod mutations may represent early diagnostic hallmarks eos infants persistent inflammation
determination network equipment weaknesses discovery intrusion intention one difficulties troubled network security management personnel based previous studies proposed double attack graph based domain equipment underlying network topology data collected analyzed using bayesian theory complete quantify double attack graph generation strategy minimal power key set cost calculation key equipment automatic recognition network topology provide important basis network maintenance experimental results show measure using quantitative domain equipment double attack graph recognize intrusion intention effective feasible also feature easy promotion
background recently role gastrointestinal nematodes modulating immune responses inflammatory immune mediated conditions allergy autoimmune diseases introduced mainly due suppressive effects somatic excretory secretory products nematodes immune responses study evaluated immunomodulatory potentials somatic products marshallagia marshalli gastrointestinal nematodes sheep suppress immune mediated responses murine model allergic airway inflammation balb mice intraperitoneally sensitized ovalbumin ova alum challenged ova somatic products marshalli administered sensitization effects somatic products development allergic airway inflammation evaluated analyzing inflammatory cells recruitment histopathological changes cytokines production tgf beta serum antibody titers igg igga results somatic products marshalli able suppress induction allergic airway inflammation mice modulation type responses igg via upregulations tgf beta production observed injection somatic products marshalli addition inflammatory cells infiltration pathological disorders significantly diminished following administration somatic products conclusions data raised possibility helminths could potential therapeutic candidate alleviate inflammatory conditions allergic asthma according results concluded marshalli may contain immune modulatory molecules attenuate allergic airway inflammation via induction regulatory cytokines investigations required identify molecules might potentials development novel therapeutic targets
paper describes analog signal processing technique development novel electronic circuit embedded photodiode sensor integrated circuit board electronic signal processing detect energy centre optical signal represents accurate position measurement light emitter source mounted structure like buildings bridges mines optical scanning sensor shm structural health monitoring proposed due fact signal processing stage embedded sensor require additional software processing reducing time memory spacing requirements information recording theoretical principle operation technological experimental aspects design development validation presented
inferring intentions beliefs another ability fundamental social affiliative interactions substantial amount empirical evidence suggests making sense another intentional belief states theory mind relies exteroceptive visual auditory proprioceptive motor signals yet despite pivotal role guidance behaviour role observer interoceptive visceral processing understanding another internal states remains unexplored predicting keeping track interoceptive bodily states inform intentions beliefs guide behaviour one fundamental purposes human brain paper focus role interoceptive predictions prescribed free energy principle making sense internal states cause another behaviour discuss multimodal expectations induced deep high hierarchical levels necessarily entail interoceptive predictions contribute inference others heart theory mind authors published elsevier inc
based findings postnatal tactile stimulation favorable experience rats present study examined influence prenatal juvenile behavior adult amphetamine amph sensitization structural alteration prefrontal cortex pfc striatum female rats received baby hair brush throughout pregnancy pups born tested open field locomotion elevated plus maze epm novel object recognition play fighting behaviors development persistence drug induced behavioral sensitization adults tested repeated amph administration challenge respectively structural plasticity brain assessed prefrontal cortical thickness striatum size serial coronal sections results indicate females showed enhanced exploration open field decreased frequency playful attacks whereas response face evade attack affected anxiety like behavior cognitive performance influenced amph administration resulted gradual increase locomotor activity behavioral sensitization persisted least weeks however male female rats exhibited attenuated amph sensitization compared sex matched controls furthermore drug associated alteration prefrontal cortical thickness striatum size observed controls prevented experience summary prenatal development modified juvenile behavior attenuated drug induced behavioral sensitization adulthood reorganized brain regions implicated drug addiction elsevier rights reserved
thermodynamic analyses high pressure methane adsorption shale rarely reported lack reliable approach obtaining true adsorption uptake observed adsorption isotherms routinely used oversimplified clausius clapeyron approximation work extends previously proposed dual site langmuir adsorption model calculate isosteric heat adsorption analytically observed adsorption isotherms high pressure methane adsorption isotherms longmaxi shale sichuan china mpa calculated isosteric heat adsorption considers real gas behavior bulk methane adsorbed phase volume neglected approximation method temperature dependence well uptake dependence isosteric heat readily investigated former revealed using approximation influence adsorbed phase gas behavior real gas ideal gas isosteric heat adsorption also investigated shows neglecting either real gas behavior adsorbed phase volume always results overestimation isosteric heat adsorption henry law regime low pressure low adsorption uptake surface occupancy isosteric heat adsorption methane longmaxi shale approximately constant mol decreases significantly higher pressures work therefore justifies method obtain true isosteric heat adsorption high pressure methane shale lays foundation future investigations thermodynamics heat transfer characteristics interaction high pressure methane shale elsevier ltd rights reserved
prevalence diabetes metabolic disorders noticeably increased worldwide causal link increasing risk type diabetes exposure environmental pollutants reported hypothesized exposure methyl tert butyl ether mtbe oxygenate additive gasoline would hinder zinc glucose homeostasis rats male sprague dawley rats received mtbe drinking water days end treatment pancreas blood samples collected biochemical molecular examinations expression four candidate genes including insulin insulin mta slca real time quantitative pcr pcr well biochemical parameters including fasting blood glucose fbs triglycerides cholesterol cho low density lipoprotein ldl high density lipoprotein hdl copper calcium levels well high sensitive reactive protein assessed endpoints study suggested mtbe exposure associated disruption zinc homeostasis glucose tolerance
embodied cognition theory proposes individuals abstract concepts associated sensorimotor processes authors examined effects teaching participants novel embodied metaphors based prior physical experience found evidence suggesting lead embodied simulation suggesting refinements current models embodied cognition creating novel embodiments abstract concepts laboratory may useful method examining mechanisms embodied cognition elsevier rights reserved
globalization economic development application mathematics throughout various areas probability statistics use modern engineering social economic research core mathematics mathematical modeling provides new way thinking economic problems economic decision making issues mathematical model probability statistics economic field
letter propose road structure refined convolutional neural network rsrcnn approach road extraction aerial images order obtain structured output road extraction deconvolutional fusion layers designed architecture rsrcnn training rsrcnn new loss function proposed incorporate geometric information road structure cross entropy loss thus called road structure based loss function experimental results demonstrate trained rsrcnn model able advance state art road extraction aerial images terms precision recall score accuracy
purpose review objective review advances bile acids health disease published last years bile acid diarrhea bad recognized common cause chronic diarrhea recognition facilitated development new screening tests recent findings primary bad account cases chronic diarrhea mechanisms leading bad include inadequate feedback regulation fibroblast growth factor fgf ileal enterocytes abnormalities synthesis degradation proteins involved fgf regulation hepatocytes variations function bile acid receptor tgr gpbar sehcat widely used test diagnosis bad significant validation fasting serum fgf ahydroxy cholesten one surrogate measure bile acid synthesis bile acid sequestrants primary treatments bad farnesoid receptor fgf pathway provides alternative therapeutic targets bad bile acid stimulated intestinal mechanisms contribute beneficial effects bariatric surgery obesity glycemic control treatment recurrent clostridium difficile infection summary renewed interest role bile acids leading novel management diverse diseases besides bad
paper proposes novel method semi regular remeshing triangulated surfaces achieve superior triangles lead advanced visualization model based mesh segmentation subdivision surface fitting uses curvature adapted polygon patches contribution lies building sophisticated system three stages curvature aware mesh segmentation submesh surface fitting generate high quality semi regular mesh finally stitching segments using efficient algorithm method uses centroidal voronoi tessellation lloyd relaxation generate curvature adapted site centers geodesic distances site centers used labeling segments indexing corner vertices segment boundary using information site centers corner vertices feature adapted polygonal patches generated segment patches subdivided optimized using squared distance metric adjust position subdivision sampling segment details prevent oversampling last efficient stitching algorithm introduced connect regular submeshes together build final semi regular mesh demonstrated results semi regular remeshing algorithm meshes different topology complexity compared known methods superior triangle quality higher aspect ratio together acceptable distortion error achieved according experimental results
variations sex hormones influence bone health men aging men associated decrease testosterone levels examined relationship levels changes bone health status measured quantitative ultrasound qus phalanges calcis peripheral bone mineral density pbmd phalanges healthy elderly spanish men examined men aged years assessed total serum concentrations total serum comparisons measured bone parameters higher normal serum group multiple regression analysis revealed serum independent predictor qus calcaneus phalangeal pbmd data indicate independent determinant qus calcis pbmd phalanges elderly spanish men
celestial spectrum contains great deal astrophysical information analysis spectra people get physical information celestial bodies well chemical composition atmospheric parameters implementation lamost sdss telescopes large scale surveys massive spectral data produced especially along formal operation lamost spectral data generated observation night requires efficient processing technology cope massive spectra automatic classification stellar spectra basic content spectral processing main purpose paper research automatic classification massive stellar spectra lick index set standard indices defined astronomical spectra describe spectral intensity spectral lines represent physical characteristics spectra lick index relatively wide spectral characteristics line index named prominent absorption line paper bayesian method used classify stellar spectra based lick line index divides stellar spectra three subtypes first lick line index spectra calculated characteristic vector spectra bayesian method used classify spectra massive spectra computation lick indices spectral classification using bayesian decision method implemented hadoop use high throughput good fault tolerance hdfs combined advantages mapreduce parallel programming model efficiency analysis processing massive spectral data improved significantly main innovative contributions thesis follows using lick indices characteristic classify stellar spectra based bayesian decision method implementing parallel computation lick indices parallel classification stellar spectra using bayesian based hadoop mapreduce distributed computing framework
gras gene family performs variety functions plant growth development processes also play essential roles plant response environmental stresses medicago truncatula diploid plant small genome used model organism despite vital role gras genes plant growth regulation studies genes truncatula conducted date using truncatula reference genome data identified mtgras genes classified groups phylogenetic analysis located eight chromosomes structure analysis indicated mtgras genes retained relatively constant exon intron composition evolution truncatula genome closely related members phylogenetic tree similar motif compositions different motifs distributed different groups mtgras genes sources functional divergence twentyeight mtgras genes expressed six tissues namely root bud blade seedpod nodule flower tissues suggesting putative function many aspects plant growth development nine mtgras genes upregulated cold freezing drought aba salt stress treatments indicating play vital roles response abiotic stress truncatula study provides valuable information utilized improve quality agronomic benefits truncatula plants
structure oceanic spreading centres subsurface melt distribution within newly formed crust largely understood marine seismic experiments iceland however sub aerial rift elevation allows accurate surface mapping installation large broadband seismic arrays present study using ambient noise rayleigh wave tomography image volcanic spreading centres across iceland high resolution model images continuous band low seismic velocities parallelling three segments branched rift iceland upper contains strong velocity variations shear wave velocities faster older non volcanically active regions compared active rifts slow velocities correlate closely geological surface mapping contours anomalies parallelling edges neo volcanic zones low velocity band extends full width neo volcanic zones demonstrating significant contrast narrow wide magmatic zone seen fast spreading ridges rate melt supply similarly high within seismically slow rift band lowest velocity cores anomalies occur centre mantle plume vatnajtikull icecap eastern volcanic zone central volcano katla suggests localisation melt accumulation specific volcanic centres demonstrating variability melt supply shallow crust along rift axis shear velocity inversions depth show strongest velocity contrasts found upper show slight depression shear velocity mid crust rifts model also shows less intensity slow rift anomaly western volcanic zone supporting notion rift activity decreasing ridge jumps eastern volcanic zone author published elsevier
sustainability housing units improved integrating green building equipment systems energy efficient hvac systems building envelopes water heaters appliances water efficient fixtures use green building measures often improves environmental social performances housing units however increase initial cost life cycle cost paper presents multi objective optimization model capable optimizing housing design construction decisions order generate optimal near optimal tradeoffs among three sustainability objectives maximizing operational environmental performance housing units maximizing social quality life residents minimizing life cycle cost model designed multi objective genetic algorithm provide capability optimizing multiple housing objectives criteria include minimizing carbon footprint water usage housing operational phase maximizing thermal comfort enhancing indoor air lighting quality improving neighborhood quality minimizing life cycle cost application example analyzed illustrate use developed model evaluate performance results analysis illustrate novel capabilities model generating near optimal tradeoff solutions analyzed housing example represents optimal near optimal unique tradeoff among aforementioned three sustainability optimization objectives maximizing operational environmental performance housing units maximizing social quality life residents minimizing life cycle cost novel capabilities developed model expected improve design construction housing units maximize overall sustainability elsevier rights reserved
implantable devices like artificial cardiac pacemakers generally used control irregular pulses heart year usage high accuracy supply voltage essential unavoidable aging power system achieve near natural beat rhythm self calibration buck converter buck proposed achieve high output voltage accuracy eliminating offset caused mismatch process voltage temperature pvt furthermore discontinuity affects transient performance conventional offset cancellation also overcome large area occupation required decrease mismatch conventional operational amplifier largely decreased according monte carlo analysis without trimming process proposed buck technique achieves high accuracy long term usage years low cost test chip fabricated umc cmos process proves output voltage accuracy since mismatch error amplifier suppressed
mixed valence polyoxometalate electrons usually delocalized within cluster anion low level inter cluster interaction herein report structure electrical properties single crystal mixed valence polyoxometalates electrically wired cationic molecules tetrathiafulvalene substituted pyridinium electron transport characteristics suggested represent electron hopping strong interactions cluster cationic molecules
trace element zinc essential immune function regulation since zinc deficiency allergic hyperresponsive reactions often accompanied influence zinc allergen induced cell growth regulatory treg cell numbers cytokine expression allergic immune reactions investigated peripheral blood mononuclear cells pbmcs non atopic atopic subjects treated timothy grass allergen pre incubated without zinc proliferation determined analyzing incorporation thymidine intracellular zinc foxp levels cell surface antigens measured facs cytokine expression elisa real time pcr incubation zinc sulfate enhances cytosolic zinc concentrations cells data also reveal combination plus allergen significantly reduces pbmc proliferation atopic subjects additionally plus allergen enhances cytokine responses shown increased interferon ifn gamma interleukin ratios well enhanced tumor necrosis factor alpha release response allergen zinc increases treg cells upregulates mrna expression cytotoxic lymphocyte antigen atopic subjects interestingly alone leads increase cdhigh cells atopic non atopic subjects zinc may regulate unwanted hyperresponsive immune reactions suppressing proliferation significant shift cytokine ifn gamma enhanced regulatory cell numbers therefore zinc supplementation may promising tool therapy allergies without negatively affecting immune system
data structures relations becoming increasingly complex difficult assess manage although automated rules algorithms used many data mining tasks still situations human attention insight required identify unexpected circumstances unanticipated patterns presentation large quantities data always challenging task paper method representing large graph based data sets proposed help users navigate large clusters data proposed method based stereoscopic visualization special enhancements large multi node graph visualization stereoscopic projection allows utilization techniques draw users attention particular regions graph method uses specially established node node relations calculate attention drawing factor values graph node
although many researchers explored relations among gender identification discriminatory attributions intentions challenge discrimination examined causal impact gender identity salience women actual responses sexist encounter current study addressed question experimentally manipulating salience gender identity assessing impact women decision confront sexist comment simulated online interaction female participants randomly assigned complete short measure either personal collective self esteem designed increase salience personal versus gender identity given opportunity confront male interaction partner expressed sexist views compared primed focus personal identity participants primed focus gender identity perceived interaction partner remarks sexist likely engage confrontation highlighting powerful role subtle contextual cues shaping women perceptions responses sexism findings important implications understanding gender identity salience antecedent prejudice confrontation online slides instructors want use article teaching available pwq website http journals sagepub com page pwq suppl index
visual tracking widely used many vision fields one active research topics computer vision recent years however still challenges visual tracking illumination change object occlusion appearance deformation overcome difficulties reliable point assignment rpa algorithm based wavelet transform proposed reliable points obtained searching location holds local maximal wavelet coefficients since local maximal wavelet coefficients indicate high variation image reliable points robust image noise illumination change appearance deformation moreover kalman filter applied detection step speed detection processing reduce false detection finally proposed rpa integrated tracking learning detection tld framework kalman filter improves tracking precision also reduces false detections experimental results showed new framework outperforms tld kernelized correlation filters respect precision measure average overlap percent
current work present methodology development item response theory model within non linear mixed effects framework characterize longitudinal changes movement disorder society sponsored revision unified parkinson disease rating scale mds updrs endpoint parkinson disease data obtained parkinson progression markers initiative database included observations months subjects belonging novo cohort probability obtaining score reported items questionnaire modeled function subject disability initially single latent variable model explored characterize disease progression time however based understanding questionnaire set results residuals based diagnostic tool three latent variable model mixture implementation able adequately describe longitudinal changes total score level also individual item level linear progression rates obtained patient reported items non sided items similar roughly take months typical subject progress linearly baseline one standard deviation however sided items found better side deteriorates quicker disabled side study presents framework analyzing mds updrs data adapted traditional updrs data collected clinical trials result efficient designs analyses studies
main design criteria modern sustainable development vehicle powertrains high energy efficiency conversion system competitive cost lowest possible environmental impacts need efficiency improvement vehicle energy system induces search innovative methodology design process article energy services mobility comfort integrated energy integration mobility comfort service applied innovative methodology combining process integration techniques methodology applied energy integration study hybrid electric vehicle powertrain vehicle cabin energy balance internal combustion engine done discussed according operating points energy requirement comfort cabin also determined according seasonal requirement heating cooling work cycles heat recovery described investigated minimum energy requirement determined different mobility comfort situations energy recovery potential single stage rankine cycle diesel engine combination hybrid electric powertrain assessed rankine cycle circuit equipment simultaneously presided
objective purpose article compare injury patterns skeletally mature patients versus skeletally immature patients better understand factors cause specific injury appearance physis essential factor injury manifestation examined conclusion physis immature chondroosseous junctions operate weak links immature skeleton deciding factors pattern injury even though injury mechanisms identical adults
backgroundthe aim present study investigate whether age menarche associated non alcoholic fatty liver disease nafld later life methodsthe association age menarche obesity insulin resistance nafld menopause investigated cross sectional study postmenopausal chinese women nafld diagnosed hepatic ultrasound information regarding age menarche collected using interviewer administered questionnaire resultswomen age menarcheyears logistic regression revealed women earlier menarche higher risk age adjusted prevalence overweight obesity insulin resistance nafld whereas later menarche showed weaker still significant association lower prevalence nafld however adjustment variables current body mass index bmi homeostasis model assessment insulin resistance homa attenuated association later menarche lower prevalence nafld decreasing trend risk nafld seen across increasing levels age menarche age adjusted trend multivariate adjusted trend multivariate current bmi adjusted trend multivariate homa adjusted trend conclusionage menarche associated prevalence nafld later life independent bmi insulin resistance
luteinizing hormone rises dramatically menopause correlated increased incidence alzheimer disease decreased memory performance humans animal models test whether acts directly dorsal hippocampus affect memory ovariectomized female rats infused either homologue human chorionic gonadotropin hcg receptor antagonist deglycosylated hcg hcg infusion hcg either lateral ventricle dorsal hippocampus caused significant memory impairments ovariectomized estradiol treated females consistent infusion antagonist hcg dorsal hippocampus caused amelioration memory deficits ovariectomized females furthermore gonadotropin releasing hormone antagonist antide failed act hippo campus affect memory findings demonstrate significant role action dorsal hippocampus spatial memory dysfunction elsevier inc rights reserved
purpose evaluate characteristics nonresearch industry payments radiologists associations regional diagnostic imaging utilization methods using cms open payment data disclosed nonresearch related industry payments radiologists identified health resources services administration area health resources files used identify actual population weighted numbers radiologists state utilizing random beneficiary sample cms research identifiable files average medicare imaging spending per beneficiary state calculated average frequency dollar amounts nonresearch non royalty payments radiologists calculated state level using pearson correlation coefficient relationship frequency amounts nonresearch payments radiologists versus per beneficiary medicare imaging spending evaluated state level results overall radiologists diagnostic interventional received nonresearch nonroyalty payments industry representing radiologists nationwide total individual transfers translated discrete payments per receiving radiologist mean median range food beverage expenses constituted vast majority disclosed transfers followed travel lodging consulting fees educational expenses considerable geographic variation payments observed ranging radiologists vermont district columbia correlation identified average per beneficiary medicare imaging spending proportion nonresearch funded radiologists state similarly correlation identified average per beneficiary medicare imaging spending average nonresearch transfer amount radiologists state conclusions small minority united states radiologists received nonresearch payments industry state level medical imaging utilization seem influenced financial relationships
although olfactory sense always considered less interest visual auditive somatic senses plays major role ordinary life important implication dangerous situations social emotional behaviors traditional diffusion tensor signal model related tractography used past years reconstruct cranial nerves including olfactory nerve however supplementary information regard pathways olfactory network provided using advanced constrained spherical deconvolution csd diffusion model show first time vivo non invasively healthy humans olfactory system widely distributed anatomical network several cortical regions well many subcortical structures although present study focuses healthy sample size similar approach could applied near future gain important insights regard early involvement olfaction several neurodegenerative disorders
recent studies shown plumbagin anti inflammatory anti allergic antibacterial anti cancer activities however yet shown whether plumbagin suppresses alpha melanocyte stimulating hormone msh induced melanin synthesis prevent hyperpigmentation study demonstrated plumbagin significantly suppresses msh stimulated melanin synthesis mouse melanoma cells understand inhibitory mechanism plumbagin melanin synthesis performed cellular cell free tyrosinase activity assays analyzed melanogenesis related gene expression demonstrated plumbagin directly suppresses tyrosinase activity independent transcriptional machinery associated melanogenesis includes micropthalmia associated transcription factor mitf tyrosinase tyr tyrosinase related protein tyrp also investigated whether plumbagin toxic normal human keratinocytes hacat lens epithelial cells may injured using skin care cosmetics surprisingly lower plumbagin concentrations effectively inhibited melanin synthesis tyrosinase activity cause toxicity keratinocytes lens epithelial cells mouse melanoma cells suggesting plumbagin safe dermal application taken together results suggest inhibitory effect plumbagin pigmentation may make acceptable safe component use skin care cosmetic formulations used skin whitening
background male patients tend meniscal chondral injuries time anterior cruciate ligament acl reconstruction females studies examined sex specific predictors meniscal chondral lesions acl injured patients purpose identify sex specific predictors meniscal chondral lesions well meniscal tear management patients undergoing acl reconstruction study design cohort study level evidence methods data collected prospectively patients males undergoing acl reconstruction predictors meniscal tears meniscal tear management chondral injuries determined using multivariate logistic regression models stratified sex predictors age body mass index bmi mechanism contact noncontact type high impact sports basketball football soccer skiing sports sports related injury interval injury surgery weeks instability episodes none odds ratios cis reported results males lateral medial meniscal tears well lateral predicted medial meniscal tears high impact sports predicted medial meniscal tears medial meniscectomies medial meniscal repairs injuries predicted lateral meniscectomies repairs instability episodes predicted medial meniscectomies conclusion sex differences observed males predictors included age bmi sports related injuries injuries weeks surgery instability episodes females predictors included age bmi instability episodes
purpose paper develop model individual social behavior incorporates contributions personality actor relevant features situation performing analyzing original formula lewin viz paper first considers importance accorded situation previous theorizing asianness analyzes contributions actor personality noting particular actors come develop broad expectancies situational outcomes associated situations encounter situations glossed social psychological purposes terms affordances potential yields relative actor motivations sociality status situational affordances defined normative prescriptions believed operative situation acceptable enactments behaviors aimed attaining actor goals sociality status normative pressure objective though may judged actor termed component situation held degree consensus others observers situation two components specify strength situation social psychological purposes yielding elaborated lewinian formula culture participants national organizational familial dyadic determine beta weights linking components formula
reduced expression brain derived neurotrophic factor bdnf implicated pathophysiology schizophrenia bdnf valmet polymorphism results deficient activity dependent secretion bdnf associated clinical features schizophrenia investigated effect polymorphism prepulse inhibition ppi translational model sensorimotor gating disrupted schizophrenia utilized humanized bdnfvalmet hbdnf valmet mice modified carry valmet polymorphism well express humanized bdnf vivo also studied long term effect chronic corticosterone cort exposure animals model history stress ppi assessed interstimulus intervals isi analysis ppi commonly used isi identified irrespective cort treatment hbdnf val met genotype associated significantly reduced ppi contrast ppi different hbdnf met met hbdnf val val genotype mice isi cort treatment selectively disrupted sensorimotor gating hbdnf val met heterozygote mice hbdnf val val hbdnf met met mice analysis startle reactivity revealed chronic cort reduced startle reactivity hbdnf val val male mice however independent effect cort ppi summary provide evidence distinct bdnfvalmet heterozygote specific phenotype using sensorimotor gating endophenotype schizophrenia data important implications clinical studies possible bdnfval met heterozygote genotype distinguished bdnfmet met genotype
background sought assess association age prevalence obesity among children without autism spectrum disorder asd national survey children health methods analyses restricted children ages valid measures parent reported weight height asd status exploratory analyses describe impact sex race ethnicity household income relationship age obesity asd results although overall prevalence obesity among children asd significantly higher among children without asd confidence interval difference child age significantly modified difference multivariable logistic regression analysis adjusted sex race ethnicity household income odds obesity among children asd compared children without asd increased monotonically ages years pattern arose due consistently high prevalence obesity among children asd decline prevalence advancing age among children without asd findings replicated using propensity score analysis exploratory analyses suggested age related change obesity disparity children without asd may modified sex race ethnicity household income conclusions patterns prevalence observed increasing age among children without asd unexpected better understanding etiological maintenance factors obesity youth asd needed develop interventions tailored specific needs children
complex offerings evolving customer needs increase demand market driven salespeople yet many today managers struggle effectively deploy selling approach light reality develop test multi level market capabilities framework examine team level drivers boundary conditions market driven salesperson behaviors norms performance data collected lagged multi source cross level field study salespeople nested within sales teams provide evidence investments team social capital itsc support self correcting customer centric learning behaviors needed performance results show managers itsc positively associated team goal monitoring commitment service quality learning effort goal monitoring learning effort increase commitment service quality helps drive sales performance also find transactive memory systems tms efficient team knowledge resource strengthens learning effort performance service quality performance relationships elsevier inc rights reserved
paper presents detailed numerical model dynamic behaviour francis turbine installed hydroelectric plant model considers detail francis turbine electromechanical subsystems main speed governor controller servo actuator turbine distributor electrical generator particular reproduces effects pipeline elasticity penstock water inertia water compressibility turbine behaviour dynamics surge tank low frequency pressure waves also modelled together main governor speed loop position controllers distributor actuator hydraulic electrovalve model validation made means experimental data hydraulic head francis turbine acquired starting tests partial revamping also involved control system distributor elsevier ltd rights reserved
irritable bowel syndrome ibs chronic functional disorder gastrointestinal tract one commonly diagnosed gastrointestinal diseases impact ibs general population large due high prevalence suboptimal medical treatments significant economic burden pathophysiology ibs complex treatments often symptom specific themost common therapeutic approaches ibs include education reassurance lifestyles especially nutrition based interventions peripherally acting medications typically target motility centrally actingmedications target visceral hypersensitivity pain psychological interventions aim reduce effects stress symptom specific anxiety beneficial dietary approach might include following measures diet low fermentable oligo monosaccharides polyols fodmaps limitation exclusion gas producing foods lactose gluten fiber supplementation selected cases new therapeutic agents namely nutraceutics also interesting option management ibs patients paper focus available dietary interventions ibs review evidence nutrition based therapies
false memories influenced variety factors emotion variable special significance theoretical practical reasons interestingly emotion effects false memory depend whether embedded content remembered events moods mood aspect context events encoded sketch theoretical basis content context dissociation review accumulated evidence content context effects indeed different paradoxically find experiments spontaneous implanted false memories negatively valenced content foments distortion negatively valenced moods protect addition correlational data show enduring negative natural moods depression foment false memory current opponent process models false memory fuzzy trace theory able explain content context dissociation variations emotional content primarily affect memory gist events whereas variations emotional context primarily affect memory events exact verbatim form important questions remain effects modulated variations memory tests arousal promising methods tackling questions outlined especially designs separate gist verbatim influences emotion
aim regenerative medicine replacing missing damaged bone tissues synthetic grafts based porous interconnected scaffolds allow adhesion growth proliferation human cells optimal design scaffolds bone tissue engineering field meet several geometrical requirements first customized replicate skeletal anatomy patient provide proper trabecular structure successfully populated cells therefore modelling scaffolds specific design methods needed conceive extremely complex structures controlling macro micro shapes purpose last years computer aided design triply periodic minimal surfaces received considerable attention since presence natural shapes structures work propose method exploit triply periodic minimal surfaces unit cell development customized trabecular scaffolds aim identify mathematical parameters surfaces order obtain target requirements bone grafts reason method implemented generative design tool allow interactively controlling porosity pores size scaffolds
tio nanotube arrays fabricated using electrochemical anodization titanium foils different types electrolytes tested determine conceptual choice nanotubes fabrication electrolytes containing nhf naso containing nhf naf containing mixture water ethylene glycol containing nhf foils marked type ethylene glycol type ammonium sulfate type sodium sulfate type sodium fluoride photocatalytic capabilities characterization fabricated ntas analyzed using sem xrd drs degradation ratio designated organic pollutants rhodamine analyzed obtained results proven foils fabricated using ethylene glycol significant photocatalytic abilities degradation ratio types respectively
considering characteristics frequent occurrence serious losses technology standpipe flat roof green building community designed alleviate urban waterlogging test carried find influence concrete height underlying surface return period reduction rate peak discharge rainwater pipe diameter results showed reduction rate peak discharge increased increase concrete height reduction rate kept constant concrete height reduction rate peak discharge increased increase roof area proportion reduction rate peak discharge decreased increase return period time results used guide practical engineering elsevier rights reserved
accurate measurement cardiomyocyte contraction critical issue scientists working cardiac physiology physiopathology diseases implying contraction impairment cardiomyocytes contraction quantified measuring sarcomere length tools available none freely distributed developed plug sarcoptim imagej fiji image analysis platform developed national institutes health sarcoptim computes sarcomere length via fast fourier transform analysis video frames captured displayed imagej thus tied dedicated video camera work real time offline latter overcoming rotating motion displacement related artifacts sarcoptim includes simulator video generator cardiomyocyte contraction acquisition parameters pixel size camera frame rate tested experimental recordings rat ventricular cardiomyocytes synthetic videos freely distributed source code available works windows mac linux operating systems camera speed limiting factor since algorithm compute online sarcomere shortening frame rates khz conclusion sarcoptim free validated user friendly tool studying cardiomyocyte contraction species including human
child labour global issue confronted many countries around globe including pakistan research conducted aim examine phenomenon child labour perspective earners children exclusively emphasises child labour affects physical psychological health children district gujrat meet targets research quantitative methodology used total children selected using simple random technique data collected questionnaires analysed using spss findings highlight children forced earn contribute family income found environment workplace adverse effects children health research insinuations future direction well specified paper
study cluster analysis discriminant analysis used assess water quality evaluate spatial temporal variations south florida purpose years data set water quality variables covering monitoring stations observations used agglomerative hierarchical grouped monitoring sites three groups low pollution moderate pollution high pollution based similarity water quality characteristics important data reduction method used assess water pollution status analysis spatiotemporal variation found stepwise five variables chi tkn water temperature important discriminating water quality parameters responsible temporal variations spatial stepwise mode identified seven variables chl tkn magnesium chloride sodium six variables tkn turbidity magnesium chloride important discriminating variables responsible spatial variations wet dry seasons respectively different patterns associated spatial variations identified depending variables considered season however overall trend environment pollution problems found low pollution region high pollution region believed results study could useful local authorities control management pollution better protection important riverine water quality elsevier rights reserved
increasing evidence indicates central nervous system cns target air pollution previously reported postnatal exposure mice concentrated ambient ultrafine particles ufp via university rochester hucaps system critical developmental window cns development equivalent human trimester produced male predominant neuropathological behavioral characteristics common multiple neurodevelopmental disorders including autism spectrum disorder asd humans current study sought determine whether vulnerability fine ufp air pollution exposure extends embryonic periods brain development mice equivalent human trimesters pregnant mice exposed day gestational days gds using new york university vaces system concentrated ambient fine ultrafine particles average concentration course exposure period postnatal days pnds neuropathological consequences characterized gestational air pollution exposures produced ventriculomegaly increased corpus callosum area reduced hippocampal area sexes sexes demonstrated hypermyelination increased microglial activation reduced total microglia number analyses iron deposition critical component myelination revealed increased iron deposition exposed female offspring males findings demonstrate vulnerability brain air pollution extends gestation produces features several neurodevelopmental disorders sexes highlight importance commonalities components particulate matter exposures source neurotoxicity common cns alterations
particle accelerators consist enormous number components many operate pulse voltage current accelerator components require precise voltage current keep beams stable reason many pulse power supplies used accelerators subsystems improve performances one example power supply scanning magnets pencil beam proton therapy use high voltage inverters high speed ramping also low voltage inverters precise current control however use intelligent digital controllers possibly simplifies precise power supplies propose method precise current control using digital control system previous work successfully controlled pulse current power supplies synchrotron main magnets next step modified previous method faster power supplies ones scanning magnets addition developed control board using high performance fpga method implemented board paper describe details proposed method experiments using small scale power supply developed control board
construction sector general characterized frequent deadlines delays budget overruns problems maintaining proper quality prevent problems common practice transfer management methods used successfully production industry article presents idea introducing lean management methodologies chosen construction processes purpose study show lean management influence total cost selected process managing storage area construction site article based study conducted authors construction office building poznan poland city center proposed new approach management introduced tested authors performed deeper analysis introducing proposed methodology processes column concreting storage area management scaffolding ordering article authors focused attention economic aspects introduced changes one storage area management showing proposed different style management influence costs analyzed processes lean methodologies used assess risk problems find suitable solution influence reduction total time cost analyzed works proposed idea lean management paper construction management solution remedy many different problems construction industry limited analyzed example authors published elsevier ltd
face growing demand electricity avoid use polluting fossil energies oil gas several countries turned renewable energies including wind turbine integration rate wind farms electrical network become increasingly significant consequently several instability problems arise far take part system services study focused control management production active reactive powers wind farm indeed power management guaranteed supervision algorithm based proportional distribution analysis transferred powers wind system estimation maximum production capacity powers carried provide necessary information algorithm guarantee accurate operation supervision algorithm proposed system order coordinate reactive power references distribution dfig stator grid converter algorithm added reactive compensation flexibility wind farm considering three operating modes presented simulation results validate algorithm developed powers supervision wind farm connected grid different operating modes
new water resources management methodologies needed address increasing demands future uncertainty urban water resources adaptive water demand management strategies provide approach improve efficiency water system operations meet water demands adapting flexibility increasing stresses droughts study simulates adaptive water demand management development complex adaptive system modeling framework couples cellular automata modeling agentbased modeling hydrologic modeling simulate land use change consumer behaviors management decisions rainfall runoff process reservoir storage model applied simulate effect demand management strategies reductions municipal water demands sustained storage surface water supply reservoir historic projected climate change hydroclimatic time series used assess effectiveness domestic water restrictions including outdoor watering restrictions rainwater harvesting rebate program high density land use change policy strategies adaptively implemented based amount water storage available framework applied evaluate strategies arlington texas metropolitan area historically suffers severe droughts framework provides approach evaluate combination multiple strategies effectively managing increasing stresses caused urbanization population growth climate change results demonstrate adaptive demand management strategies respond water shortages result long term per capita demand reductions climate projections forecast severe water shortages development density strategies effective rainwater harvesting strategies combination strategies reduce need interbasin transfers maintain reservoir volumes american society civil engineers
social perception studies revealed smiling individuals perceived favourably many communion dimensions comparison nonsmiling individuals research gender differences smiling habits showed women smile men study investigated phenomena hypothesised women perceive smiling individuals honest men experiment conducted seven countries china germany mexico norway poland republic south africa usa revealed gender may influence perception honesty smiling individuals compared ratings honesty made male female participants viewed photos smiling nonsmiling people men women differ ratings honesty nonsmiling individuals women assessed smiling individuals honest men discuss results social norms perspective
interoception exteroception body signals two different ways perceiving self first within second outside investigated relationship interoceptive accuracy iacc external perception body tested seeing body external perspective affect iacc fifty two healthy female subjects performed standard heartbeat perception task assess lacc body image revealer bir body perception task designed assess different aspects body image performance lower lacc group heartbeat perception task significantly improved exteroceptive task findings highlight relations interoceptive exteroceptive body representations supporting view two kinds awareness linked interact elsevier ltd rights reserved
nondestructive method developed assessing total viable count tvc pork refrigerated storage using hyperspectral imaging technique study hyperspectral images visible near infrared vis nir region acquired fifty pork samples vis nir diffuse reflectance spectra extracted images reference values tvc pork samples determined classical microbiological plating method partial least square regression plsr model support vector machine regression model svr tvc built comparative analysis achieve better results different transformation methods filtering methods applied improve models results show optimized plsr model svr model predict tvc well svr model based second derivation better achieved correlation coefficient prediction set sep standard error prediction set log cfu prediction set image processing algorithm developed transfer prediction model every pixel image entire sample visualizing map tvc would displayed real time detection process due simplicity model results demonstrated hyperspectral imaging potential reliable approach non destructive real time prediction tvc pork
internet digital signature indispensable approach securing commerce online transactions requiring authentication concerning computing costs signature generation verification become common practice security practitioners outsource computations heavily loaded application servers called tenants dedicated proxies like signature servers enterprise private cloud paper present high performance signature server called guess implements elliptic curve digital signature algorithm ecdsa key size linux powered commodity computer harnessing desktop graphics processing unit featured cryptographic accelerator demonstrate experience maximizing computing power guess also capability deliver power tenants includes earth customization optimization considering various hardware software factors comprehensive implementation ecdsa tested intensive network traffic field experiments show guess achieves operations per second ops signature generation ops verification significantly faster existent prototypes products guess universal server readily supports various categories elliptic curve cryptographic schemes digital signature key agreement encryption
multispan suspension bridges frictional resistance main cables saddles essential counterpoising unbalanced cable tension different spans use friction plates saddles one common methods increasing frictional resistance corresponding evaluation method vital design suspension bridges study analytical model calculation frictional resistance cables saddles presented large scale model tests performed simulate realistic friction conditions typical multispan suspension bridge china namely yingwuzhou yangtze river bridge validate model main components frictional resistance analyzed effects vertical friction plates enhancing frictional resistance investigated model tests theoretical analyses results indicate presented analytical model provides effective feasible tool evaluating total frictional resistance contribution friction plates practice main components total frictional resistance including frictions base side contact interfaces cable saddle trough quantified proving former dominant parameter analyses reveal frictional resistance increased incorporating six vertical friction plates actual saddle
communicative skills chimpanzees significant interest across many domains developmental psychology communication emerge prelinguistic beings evolution human language evolve primate gestures comparative psychology nonverbal communication chimpanzees humans compare ask gestures develop chimpanzee infants raised interactive program designed study skill development data socio communicative development collected following daily interaction infant longitudinally birth first year life consistent significant developmental pattern found across contexts tickle play grooming chase play infant chimpanzees first engaged interactions initiated others initiated interactions finally requested others join interaction gestures documented initiating requesting tickle play initiating requesting grooming initiating requesting chase play gestural requests emerged significantly later gestural initiations age gestures emerged significantly different across contexts gestures related hierarchical rank relations gestures used subordinates interaction dominant individuals wrist presenting rump presenting emerge manner gestures study offers new view development gestures specifically many develop interaction communicate socio emotional desires gestures emerge manner primatol wiley periodicals inc
review gives overview mechanisms action oral emergency contraception pills ecps focusing levonorgestrel lng ulipristal acetate upa containing ecps vivo vitro studies addressed effect various possible targets based studies well clinical trials clear efficacy ecps prevent unintended pregnancy depends mechanism action well use relation fertile window main effect available ecps prevent delay ovulation window action upa wider lng provides biological explanation difference observed clinical trials higher efficacy upa neither lng upa impairs endometrial receptivity embryo implantation correct knowledge mechanism action ecps important avoid overestimating effectiveness advise women correct use
nowadays considerable attention paid agile methods means improve management software development processes widespread use methods professional contexts encouraged integration software engineering training undergraduate courses although several research efforts focused teaching scrum simulating software development project covered learning programming practices within scrum team furthermore studies tackle nontechnical skills development practices work presented introduces original scrum based training model enhanced agile coaching maximize student performance validated case study capstone project scrum course paper summarizes positive results introducing agile coaching resulted approximately coverage software engineering practices addition survey data showed compared students receive coaching coached students gained valuable insight internalization scrum problem solving guidance means checkpoint meetings
among many energy harvesting techniques great potential microbial fuel cell mfc technology arguably underdeveloped even excitement building microorganisms harvest electrical power biodegradable organic source wastewater readily available resource limited settings nevertheless requirement endless introduction organic matter imposes limiting factor technology demanding active feeding system additional power demonstrated self sustaining bioelectricity generation microliter scale microbial fuel cell mfc using syntrophic interaction heterotrophic exoelectrogenic bacteria phototrophs mfc continuously generated light responsive electricity heterotrophic bacterial metabolic respiration organic substrates produced photosynthetic bacteria without additional organic fuel mixed culture chamber mfc generated self sustained current days heterotrophic culture produced current decreased dramatically within hours current mixed culture times greater device photosynthetic bacteria miniaturization provided short start time well controlled environment small internal resistance advantages become general design platform micropower generation elsevier rights reserved
objective main study objective identify perceived barriers achieving glycemic control among arab population israel members arab community type diabetes primary care teams working arab community methods series six focus groups using qualitative research methodology conducted two phases among people diabetes primary care professionals treating results perception disease among people diabetes one low severity barriers adopting healthy lifestyle self management included awareness need financial considerations regarding medication traditional gender roles food preparation family life identified strong cultural determinant health literacy needs depth accessible educational programs identified primary care staff viewed needs similarly exception need depth instructional materials conclusion practice implications understanding significance healthy lifestyles self management essential developing culturally appropriate implementation programs policy consultation involvement patient groups needs assessment planning essential established policy promotes best practice health promotion chronic illness
building stakeholders easily quantify environmental impacts buildings accrue construction goal work demonstrate method measure manage cradle gate life cycle environmental impacts linking environmental targets modern construction management methods enable buildings meet sustainable target values stv work construction activity based computational framework developed enable stakeholders reliably efficiently construct cradle gate life cycle models capturing environmental impacts including carbon energy associated material extraction manufacture transport site construction models allow stakeholders measure manage impact accrual exceed stvs without framework construction managers building stakeholders possess adequate environmental management tools deliver projects consistently stv specifically components developed time dependent impact accrual budgets construction impact measurement construction benchmarks used determine whether specific project target values similar methods cost schedule variance analysis two case studies used test framework integration provides life cycle assessment lca modeling platform management environmental footprint construction published elsevier ltd
monte carlo method used quantitative structure activity relationships modeling quinoline isoquinoline derivatives acting dipeptidyl peptidase inhibitors quantitative structure activity relationships models calculated representation molecular structure simplified molecular input line entry system one random split training test set statistical quality developed model good best calculated quantitative structure activity relationships model following statistical parameters training set test set structural indicators defined molecular fragments responsible increases decreases inhibition activity calculated computer aided design new compounds potential dipeptidyl peptidase inhibitors application defined structural alerts presented
manuscript describe fundamentally novel approach design anti aliasing filters approach termed filtering aliasing incorporates frequency domain aliasing operation filtering task spectral content spread periodic mixer weighted simple analog filter aliases sampler designing system according formulations presented manuscript sampled output subjected sharp highly programmable anti alias filtering manuscript describes proposed filtering aliasing idea effective programmable anti aliasing filter design range frequency responses manuscript also addresses implementation sensitivities proposed filtering aliasing approach provides performance comparison existing techniques context reconfigurable anti alias filtering
main purpose paper determine dynamic characteristics structural stability two approach viaducts bosphorus suspension bridge expected stresses would caused earthquake conditions ortakoy beylerbeyi approach viaducts constitute side spans bridge two locations bridge main span bosphorus suspended whereas supported base either end numerical investigation viaducts computational structural finite element models developed natural frequencies corresponding mode shapes obtained analyzed presented compared performances viaducts earthquake conditions studied considering delta effects implementing push poa non linear time history analyses ntha ntha three earthquake ground motions generated depending location bridge seismic performances viaducts determined accordance requirements turkish seismic code earthquake design railways bridges tsc caltrans caltrans given seismic design steel bridges separately furthermore investigation extended evaluating possible need retrofitting future analysis resultant data retrofit recommendation viaducts presented
extending raney depalma research study examined effects sport production sport consumption experimental design crossed scripted unscripted sport violence nonviolence investigate effects variables violent outcomes enjoyment viewing one four clips participants responded three incomplete story stems responses coded measure hostile expectancy bias form violent outcome participants also responded enjoyment clip consumed analyses showed main effect consuming sport violence increased participants hostile expectancy bias however significant interaction showed scriptedness moderated effect violence increased hostile expectancy bias scripted condition enjoyment also affected scriptedness violence violent nonscripted sports enjoyed conditions results suggest violence sports may interpreted differently based scriptedness sport may processed differently violence forms entertainment implications findings discussed limitations future directions study
backgroundthis study describe quantify relationships among family poverty parents caregiving practices access education development children living low middle income countries lamic methodswe conducted secondary analysis data collected unicef multiple indicator cluster surveys mics early childhood development assessed four domains language cognitive physical socio emotional approaches learning countries classified three groups basis human development index hdi resultsoverall data children aged months lamic included analyses mean child development scale score maximum score low hdi countries high hdi countries family poverty associated lower child development scores countries total indirect effect family poverty child development score via attending early childhood education care child home use harsh punishments home total effect low hdi countries total effect medium hdi countries total effect high hdi countries conclusionschildren disadvantaged position societies children living low hdi countries greatest risk failing reach developmental potential optimizing care child development home essential reduce adverse effects poverty children early development subsequent life
coronary artery diseases leading cause mortality increasingly prevalent age however large number age increasing morbidities make difficult understand impact cardiovascular ageing alone coronary flow pattern present study aims shed light effect arterial ventricular ageing coronary circulation studied means validated mathematical model forward backward pressure flow waves analysed well intensity results highlight complex spatiotemporal coronary wave pattern intense waves originate aorta particularly systole deep myocardium isovolumic compression diastolic phase subendocardial viability ratio decreases age total coronary flow slightly reduced left ventricular work increases consequently left ventricular work per unit blood flow increases thus limiting cell oxygen availability abundance therefore increasing risk myocardial infarction results highlight physiological age induced supply demand unbalance augment risk myocardial ischemia contribute pave way typical coronary pathological processes
aimsprevious studies using isolated strips human detrusor muscle identified adjustable preload tension novel mechanism acutely regulates detrusor wall tension purpose investigation develop method identify correlate measure adjustable preload tension urodynamics methodspatients reporting urgency time based iciq oab survey scores prospectively enrolled extended repeat fill empty urodynamics study designed identify correlate adjustable preload tension call dynamic elasticity cystometric capacity determined initial fill repeat fills defined percentages capacity passive emptying via syringe aspiration performed strain soften bladder complete fill active voiding included determine whether human bladder exhibits reversible strain softening resultsfive patients completed extended urodynamics study intravesical pressure ves decreased subsequent fills significantly lower fill compared fill demonstrating strain softening active voiding fill caused strain softening reversal ves fill returning baseline measured fill dynamic elasticity urodynamic correlate adjustable preload tension calculated amount strain softening reversal per capacity average ves fills capacity dynamic elasticity lost via repeat passive filling emptying strain softening regained active voiding regulated process strain softening reversal conclusionsimproved understanding dynamic elasticity human bladder could lead improved sub typing novel treatments overactive bladder neurourol urodynam wiley periodicals inc
paper presents information system multidimensional data analysis data mining identification associative dependences multidimensional data implemented post relational dbms cache environment information system modules considered perform next tasks design object database physical level provisioning construction multidimensional data structures creation database association rules mining among multidimensional data methods olap cubes construction considered well association rules mining implemented information system
ethnopharmacological relevance kuntai capsule traditional chinese medicine widely used clinical treatment menopausal syndrome however mechanisms remain poorly understood considering aging ovaries primary cause menopause study designed investigate effects mechanisms kuntai capsule ovarian function novel mice model accelerated aging ovaries materials methods seventy five female cbl mice chosen study fifteen mice separated normal control group remaining sixty used establish novel accelerated aging ovary model superovulation oxidative stress randomly dividing mice four equal groups one group considered model group mod three groups treated low middle high doses kuntai capsule intragastrically every day weeks treatment body weight fur condition mice recorded mice forced swim record exhaustive swimming time est measures strength mice sacrificed sampling ovarian reserve evaluated using follicle counts amh expression ovarian function evaluated using estrous cycle sex hormone level litter experiments ovarian follicles categorized counted estimate ovarian reserve ovarian histologic sections stained terminal deoxynucleotidyl transferase mediated dutp nick end labeling tunel detect apoptotic cells ultrastructure ovarian cells observed using transmission electron microscopy western blotting used measure expression bax bcl amh sod protein results compared group mod group clearly displayed worse fur condition ovarian function situations showed improvement kuntai capsule treatment specifically fur condition est kuntai capsule groups superior fur condition est mod group cases damaged ovarian function kuntai capsule regulate estrous cycles increase hormone secretion fertility significantly decrease atretic follicles transmission electron microscopy results revealed kuntai capsule rescued ovarian ultrastructure mice tunel staining confirmed apoptotic cells reduced kuntai capsule treatment western blotting revealed kuntai capsule increase amh sod protein expression decrease bax expression conclusions kuntai capsule may improve damaged ovarian function may related antioxidant anti apoptosis effects
evaluate effect continuing care interventions cocaine use hiv risk reduction components hiv sex risk explore whether cocaine use treatment initiation interacts type continuing care intervention affect hiv sex risk cocaine dependent participants randomized treatment usual tau intensive outpatient treatment tau telephone monitoring counseling tmc tau tmc plus incentives participation telephone contacts tmc participants tmc tmc received brief hiv intervention booster sessions needed generalized estimating equations analysis compared tau tmc tmc months post baseline following outcomes overall hiv sex risk number sexual partners condom usage exchange drugs sex exchange sex drugs exchange money sex exchange sex money crack house visits overall sex risk decreased treatment conditions follow treatment main effects people cocaine use baseline tau experienced greater sex risk reductions tmc tmc three treatment conditions effective reducing hiv sex risk tmc hiv risk reduction components unnecessary cocaine dependent clients stop using cocaine early treatment
aim study determine whether nature drug crime relationship differs function participant age adolescent adult hypothesized drug crime interaction would predict subsequent drug use serious offending early mid adolescents adults participants came offending crime justice survey conducted england wales hypothesis supported results two separate two equation multivariate linear regression analyses findings indicate relationship drug use criminal offending varies function participant age relationship interactive formative years becomes cumulative additive early adulthood research theoretical practical implications results discussed
background society thoracic surgeons sts american college cardiology transcatheter valve therapy tvt registry captures procedures food drug administration approved transcatheter valve devices performed united states mandated condition reimbursement centers medicaid medicare services objectives annual report focuses patient characteristics trends outcomes transcatheter aortic mitral valve catheter based valve procedures united states methods reviewed data patients receiving commercially approved devices december entered tvt registry results patients transcatheter aortic valve replacement demonstrated decreases expected risk day operative mortality sts predicted risk mortality prom transcatheter aortic valve replacement prom tvt prom observed hospital mortality decreased year mortality decreased however day post procedure pacemaker insertion increased patients underwent transcatheter mitral leaflet clip similar patients hospital mortality mitral regurgitation reduced grade patients patients underwent mitral valve invalve mitral valve ring procedures high risk sts prom mitral valve replacement observed hospital mortality day post procedure mortality conclusions tvt registry innovative registry monitors quality patient safety trends rapidly evolving new technologies coll cardiol american college cardiology foundation society thoracic surgeons published elsevier inc behalf american college cardiology foundation rights reserved
mass market head mounted displays hmds currently attracting wide interest consumers allow immersive virtual reality experiences affordable cost flying virtual environment common application hmd however conventional keyboard mouse based interfaces decrease level immersion motivation design three types immersive gesture interfaces bird superman hand flyover navigation kinect depth camera used recognize gesture extracting analyzing user body skeletons evaluate usability interface user study result analyze advantages disadvantages interface demonstrate gesture interfaces preferable obtaining high level immersion fun hmd based environment
hysteresis class smart material based actuators represented adopting prandtl ishlinskii model controller designed based indirect adaptive robust control framework order reduce hysteresis effect least squares method line parameter estimation associated approximate model inverse compensation employed inversion error analyzed quantitatively robust controller designed accommodate uncertain nonlinearities make system stable simulation shows adaptive robust controller good output tracking performance also accurate parameter estimates
seaweed constituents traditionally employed management various human pathologic conditions edema urinary disorders inflammatory anomalies current study performed investigate antioxidant anti arthritic effects fucoidan undaria pinnatifida noteworthy vitro antioxidant potential diphenyl picrylhydrazyl scavenging assay inhibition nitrogen oxide inhibition assay hydroxyl scavenging assay iron chelating assay substantial ascorbic acid equivalent reducing power ascorbic acid equivalent total antioxidant capacity suggested fucoidan good antioxidant agent regulation cox expression rabbit articular chondrocytes dose time dependent manner unveiled vitro anti inflammatory significance vivo carrageenan induced inflammatory rat model demonstrated inhibition inflammation whereas inflammation inhibition potential recorded anti arthritic complete freund adjuvant induced arthritic rat model substantial ameliorating effect altered hematological biochemical parameters arthritic rats also observed therefore findings present study prospects fucoidan potential antioxidant effectively abrogate oxidative stress edema arthritis mediated inflammation mechanistic studies recommended observed activities elsevier rights reserved
background psoriasis associated numerous comorbidities often reported terms relative risk doctors general population tend overestimate effects exposures presented relative terms leading anxiety potentially poor treatment decisions absolute risks might provide better basis risk assessment objective characterize compare relative absolute risks comorbidities patients psoriasis methods systematic review using medline identified comorbidities associated psoriasis relative risks information calculating absolute risks results comorbidities associated psoriasis highest relative risk nonmelanoma skin cancer melanoma lymphoma relative risks respectively attributable risk conditions per person years respectively attribute event conditions psoriasis would require seeing patients respectively limitations database studies might fully account confounders resulting overestimates risk impact comorbidities conclusions presenting attributable risk form number needed harm provides clearer picture magnitude risk basis wiser medical decision making patient education
data integration problem combining set heterogeneous autonomous data sources providing user unified view data integrating data raises several challenges since designer usually encounters incompatible data models characterized differences structure semantics one hardest challenges define correspondences schema elements attributes determine relate since business data currently stored relational databases present declarative formal approach specify correspondences relational schema components differently usual approaches cas semantics deal outer joins data metadata relationships finally demonstrate use cas generate mapping expressions form sql queries present preliminary tests verify performance generated queries
study objectives investigated generally unappreciated feature sleep disorder narcolepsy patients mistake memory dream real experience form sustained delusions significant events design interviewed patients narcolepsy healthy controls establish prevalence complaint identify predictors setting academic medical centers boston massachusetts leiden netherlands participants patients diagnosis narcolepsy cataplexy age matched healthy healthy controls interventions measurements results dream delusions surprisingly common narcolepsy often striking severity opposed fleeting hypnagogic hypnopompic hallucinations sleep wake transition dream delusions false memories induced experience vivid dream led false beliefs could persist days weeks conclusions delusional confusion dreamed events reality prominent feature narcolepsy suggests possibility source memory deficits disorder yet fully characterized
sports related distal radius fractures srdrf represent fractures affecting upper extremity type fracture occurs frequently males females average age presentation years pediatric population peak incidence sports injuries years high impact sports football basketball soccer carry especially high risk type injury however wide variety sport disciplines different characteristics demand velocity energy use upper extremities uniform pattern srdrf general principles diagnosis treatment distal radius fractures athletes part follow general population however unique aspects clinical approach srdrf athlete frequently require additional radiographic views common need advanced imaging computer tomography scans magnetic resonance imaging athletes constitute special patient population elite athletes highly motivated return competition soon possible frequently willing accept risk poor healing repeat injury treating physician may subjected pressure prematurely end immobilization reduce recovery time even remove plates alter therapy based competition requirements influences mitigated favor long term benefit patient elsevier inc rights reserved
purpose review examine definition asthma copd overlap syndrome acos current treatment strategies recent findings patients acos lower quality life suffer complications affected either disease alone diagnosis acos difficult clinical similarities two diseases various phenotypes comprise syndrome defining treatment strategies acos challenging many clinical trials asthma therapy purposefully excluded patients features copd copd clinical trials included patients might asthmatic component disease therefore randomized treatment trials included patients acos summary smoking cessation appropriate vaccinations cornerstone therapies pharmacologic therapy focused bronchodilators inhaled corticosteroids role biologics omalizumab antagonists acos treatment still defined paucity randomized control trials guiding treatment strategies global initiative asthma gina global initiative chronic obstructive lung disease gold guidelines recommend treating acos according dominant phenotype
appropriately merging visual words effective dimension reduction method bag visual words model image classification approach hierarchically merging visual words extensively employed gives fully determined merging hierarchy existing supervised hierarchical merging methods take different approaches realize merging process various formulations paper propose unified hierarchical merging approach built upon graph embedding framework approach able merge visual words scenario preferred structure undesired structure defined therefore effectively attend kinds requirements word merging process terms computational efficiency show algorithm seamlessly integrate fast search strategy developed previous work thus well maintain state art merging speed best survey proposed approach first one addresses hierarchical visual word mergence flexible unified manner demonstrated maintain excellent image classification performance even significant dimension reduction outperform existing comparable visual word merging methods broad sense work provides open platform applying evaluating developing new criteria hierarchical word merging tasks
propose model volunteering test validity across four cultural groups hypothesize individuals explicit prosocial motivation relates positively sustained volunteering conceptualized latent factor comprising activity volunteer service length service frequency hours volunteering moreover introduced implicit prosocial motivation hypothesized relationship explicit prosocial motivation sustained volunteering would amplified implicit prosocial motivation data collected samples china germany turkey united states results confirmed expectation across cultures sustained volunteering associated explicit prosocial motivation relationship explicit prosocial motivation sustained volunteering strongest implicit prosocial motivation also high including implicit prosocial motivation study offers novel approach identifying sustained volunteer involvement particular relevance recruitment activities voluntary organizations across various cultural contexts
study examines influence three informal institutions performance orientation self expression social desirability extent internationalization early stage entrepreneurial firms employed multi level modeling techniques using individual level responses obtained global entrepreneurship monitor gem survey countries supplementing country level data obtained world values survey wvs global leadership organizational behavior effectiveness globe study results demonstrate high performance orientation high self expression low social desirability entrepreneurship societies increase extent internationalization early stage entrepreneurial firms study promotes new theory empirical findings relationship informal institutions entrepreneurial agency elsevier ltd rights reserved
background little known frontolimbic abnormalities thought underlie borderline personality disorder bpd endeavoured study regional responses well connectivity habituation emotion processing methods bpd patients normal female controls controlled menstrual phase underwent emotion induction fmri task using standardised images block design performed psychophysiological interaction ppi analysis investigate functional connectivity results bpd patients reported disgust questionnaires compared controls relative showed reduced left amygdala increased dorsolateral prefrontal cortex dlpfc activation emotions collapsed versus neutral habituation ventral striatal activity repeated emotional stimuli observed controls bpd finally context disgust emotions versus neutral bpd patients displayed enhanced left amygdala coupling dlpfc ventral striatum limitations strict inclusion criteria reduced sample size conclusions summary bpd showed abnormal patterns activation habituation connectivity regions linked emotion regulation amygdala deactivation may mediated abnormal top regulatory control dorsolateral prefrontal cortex aberrant emotion processing may play unique role pathophysiology bpd
original task scheduling algorithm hadoop meet performance requirements heterogeneous clusters according dynamic change load task node difference node performance different tasks heterogeneous hadoop cluster novel adaptive task scheduling strategy based dynamic workload adjustment atsdwa presented atsdwa tasktrackers adapt change load runtime obtain tasks accordance computing ability realize self regulation avoiding complexity algorithm prime reason make jobtracker system performance bottleneck experimental results show atsdwa highly efficient reliable algorithm make heterogeneous hadoop clusters stable scalable efficient load balancing furthermore performance superior original improved task scheduling strategy hadoop aspects execution time tasks resource utilization speed ratio
contact resistance interlaced conductive yarns certain circumstances constitute problem sensor applications electrical routing interactive textile structures type resistance could alter effective area sensor introduce hot spots routing paper presents technique measuring contact resistances fabric samples samples used unit cells plain weave two conductive silver coated yarns warp direction two weft direction numerical values contact resistance order approximate resistor network made hole film resistors known values used evaluation method results show technique provides values typically within error compared known resistor values thus method used order calculate contact resistances woven conductive textile
study investigated quality life adjustment mechanisms parents children attention deficit hyperactivity disorder adhd ninety parents children adhd completed sociodemographic questionnaire self assessment scales measure perceived stress social support sense control coping strategies quality life adhd children negatively affected parents quality life especially psychological well personal fulfillment family couple relationships well daily life activities also affected severity disorder perceiving situation threat loss feeling guilty holding irrational beliefs related emotion focused coping strategies poorer quality life furthermore hyperactivity index stress ratings relative perceiving situation threat loss adopting emotion focused coping strategies predicted poorer quality life contrast perceiving situation challenging related greater sense control personal fulfillment moreover perceiving situation challenging adopting problem focused coping strategies predicted better quality life findings highlight negative effects adhd parent psychological adjustment underline need recommend training programs improve parenting skills parents perceptions concerning child behavior disorder parental functioning
ethnopharmacological relevance scutellariae radix scutellaria baicalensis georgi coptidis rhizoma coptis chinensis franch known traditional chinese medicine tcm widely used effects suppressing fever dispelling dampness purging fire removing toxicosis owing unimaginable complexity difficult understand pharmacokinetic properties detail aim study develop optimal proteomics approach analyze protein profiling related adme tox rat liver treated radix rhizoma well compatibility materials methods male rats respectively administered extracts radix rhizoma mixture days liver tissue samples prepared comparative proteomic analysis significantly differentially expressed proteins experimental groups control group found identified maldi tof analyses validate proteomic analysis results glutathion peroxidase catalase betaine homocysteine methyl transferase selected confirmed western blotting results seventy eight significantly differentially expressed proteins experimental groups control group found identified querying relational databases identified differentially expressed proteins summarized classified three groups phase drug metabolic enzymes phase drug metabolic enzymes rest proteins mainly involve energy metabolism signal transduction cytoskeleton proteins involved adme tox may targets metabolic studies markers toxicity conclusions findings indicated radix rhizoma well compatibility assuredly influence expression proteins rat liver administration majority expressions presented downward trend may closely related pharmacological properties medicine method study may open new road complementary tests adme tax properties radix rhizoma well compatibility elsevier ireland ltd rights reserved
article review mitochondrial transport mitochondrial uptake exchange involved cell biology including activation differentiation shaping cellular signals based recent observations propose crosstalk mitochondria endoplasmic reticulum cytoplasm may form proportional integral derivative pid controller pid mechanism well known engineering could responsible computing cellular decisions addition point importance analogue digital signal processing cell life implication mitochondrial transport process
objectivesthe meaningful use initiative made nearly billion available incentive programs encourage provider adoption use electronic health records objective study evaluate impact outpatient physicians participation meaningful use quality care provided medicare fee service ffs enrollees designretrospective cohort study settingone hundred percent inpatient outpatient medicare ffs claims covering period january december participants medicare ffs enrollees new york state measurementshospitalizations emergency department visits ambulatory care sensitive conditions acscs diabetic retinopathy screening diabetic nephropathy screening colorectal cancer screening influenza vaccinations resultsphysician participation meaningful use initiative associated reductions acsc related hospitalizations percentage points confidence interval visits percentage points relative comparison group meaningful use participation associated higher odds colorectal cancer screening odds ratio relative comparison group diabetic retinopathy screening diabetic nephropathy screening influenza vaccinations similar results found secondary analyses dually eligible beneficiaries participating medicare medicaid conclusionphysician participation meaningful use associated substantial improvements six quality measures
hereditary angioedema hae rare genetic disease characterized episodic subcutaneous submucosal swelling primary cause common form hae deficiency functional esterase inhibitor inh swelling caused hae painful disfiguring life threatening reduces daily function compromises quality life affected individuals caregivers among different treatment strategies replacement inh concentrates employed demand treatment acute attacks long term prophylaxis three human plasma derived inh preparations approved hae treatment european union regions cinryze berinert cetor however cinryze approved long term prophylaxis postmarketing studies shown home therapy self administered administered caregiver convenient safe option preferred many hae patients review summarize role self administered plasma derived inh concentrate therapy cinryze home prophylaxis hae
objective response evidence deteriorating outcomes people schizophrenia recently published critical review journal concerning outcomes schizophrenia improving published commentary review raised criticisms aim address herein method published data related four issues raised commentary reviewed results body evidence supports possibility dramatic improvements treatment effectiveness presented critical review achieved within existing financial resources present day understanding pathophysiology schizophrenia however commentary leads highlight four current obstacles improving treatment effectiveness belief many psychiatrists long term antipsychotic medication raises cardiovascular mortality rate schizophrenia opposite almost certainly case need improve psychiatrist training diagnostic communication skills especially first episode presentations requirement comprehensive structured assessment highly prevalent deficits insight decision making capacity associated schizophrenia need improved intervention design minimise impact deficits treatment choice refusal conclusion sense professional urgency genuinely respectful caring partnership clinicians affected individuals families researchers relative little innovation conclude standard care definitely raised treatment schizophrenia
background primary cardiac tumors rare myxoma constitutes majority present study summarizes year clinical outcomes surgical myxoma resection methods january december patients men women mean age years underwent surgical myxoma resection common origin site left atrium surgery performed via biatrial approach atrial septotomy right atriotomy left atriotomy mean myxoma size based longest length range results mean follow duration years range years hospital mortality common postoperative complication atrial fibrillation year survival rates respectively recurrence occurred two patients detected months first surgery respectively conclusions long term survival myxoma resection excellent recurrence rare based experience surgical method affect outcome
computer generated images easily generated pinhole images whereas images obtained optical lenses exhibit depth field dof effect due fact optical lenses gather light across finite apertures whereas simulation pinhole lens means light gathered infinitesimal small aperture thus producing sharp images depth simulating physical process gathering light across finite aperture done example distributed ray tracing computationally much expensive simulation infinitesimal aperture usual way simulating lens effects therefore produce pinhole image post processes image approximate dof post processing algorithms fast suffer incorrect visibilities paper propose novel algorithm tackles visibility issue sparse set views rendered optical center lens several peripheral viewpoints distributed lens peripheral images warped towards central view create layered depth image ldi observed points located central view ray stacked pixel ldi pixel ldi conceptually scattered point spread function psf blended depth order scatter method inefficient gpu propose selective gather method dof synthesis scans neighborhood pixel blends colors psfs covering pixel experiments show proposed algorithm synthesize high quality dof effects close results distributed ray tracing much higher speed elsevier ltd rights reserved
article examines ecosystem biomimicry potential contribute evolution intelligent built environments ecosystem biomimicry emulation ecosystems work design context article begins ascertaining whether analysing urban built environment perspective ecosystems function could significant step towards creation built environment positive integration restoration local ecosystems could realized aim examine ecosystem biomimicry usefulness practical tool research evaluation existing built environments design new retrofitted developments significance research could provide comprehensive basis development ecosystem based biomimicry practical measurable multiple potential benefits concept ecosystem services analysed used define framework employing ecosystem biomimicry urban built environment context ranking research exercise key ecosystem services may benefit focus built environmental context identified results case study testing usability ecosystem biomimicry determine design goals retrofit existing city presented
objective direct stimulation peroneal nerve actigait implantable drop foot stimulator potent therapy described previously stroke related drop foot authors report successful long term application actigait implantable drop foot stimulator patients multiple sclerosis methods six patients years persisting central leg paresis received implantable actigait drop foot stimulator successful surface test stimulation ten weeks year surgery gait speed endurance safety evaluated patient satisfaction assessed questionnaire results gait test stimulation actigait stimulator significantly reduced time needed average approximately weeks surgery time improved year median distance covered patients stimulator minutes walking increased significantly remained stable year distance covered patients surface stimulation patients implanted actigait stimulator noticed pronounced improvement mobility social participation quality life conclusions actigait implantable drop foot stimulator improved gait speed endurance quality life patients period year may serve new therapeutic option patients related drop foot
communication ether nature erratic thus wireless networks often deemed unsuitable support time critical distributed control applications like shop floor industrial plants however scheduling techniques derived real time operating systems along channel redundancy run time retransmission management profitably applied wireless networks improve determinism tangibly paper presents novel approach combines solutions preliminary prototype implementation relies ieee set assess feasibility performance approach results show determinism data exchange improved degree makes wireless networks actually suitable many soft real time applications
given long follow periods often required treatment intervention studies potential use surrogate markers decrease required follow time attractive goal however previous studies shown using inadequate markers making inappropriate assumptions relationship primary outcome surrogate marker lead inaccurate conclusions regarding treatment effect currently available methods identifying validating surrogate markers tend rely restrictive model assumptions focus uncensored outcomes ability use methods practice primary outcome interest time event outcome difficult censoring missing surrogate information among experience primary outcome surrogate marker measurement paper propose novel definition proportion treatment effect explained surrogate information collected specified time setting time event primary outcome proposed approach accommodates setting individuals may experience primary outcome surrogate marker measured propose robust non parametric procedure estimate defined quantity using censored data use perturbation resampling procedure variance estimation simulation studies demonstrate proposed procedures perform well finite samples illustrate proposed procedures investigating two potential surrogate markers diabetes using data diabetes prevention program copyright john wiley sons ltd
background well understood one five patients report poor outcomes following knee arthroplasty study evaluated changes knee biomechanics perceived pain among patients reporting either good poor outcome knee related quality life total knee arthroplasty methods twenty eight patients mean age years included prospective study within one month knee arthroplasty one year surgery patients underwent three dimensional gait analysis completed knee injury osteoarthritis outcome score koos rated perceived pain using visual analogue scale good outcome defined change greater minimally detectable change koos knee related quality life poor outcome defined change minimally detectable change nineteen patients classified good outcome groups analyzed separately knee biomechanics compared using two way repeated measures anova differences pain groups evaluated using mann whitney test results patients classified good outcome improved significantly knee gait biomechanical outcomes including increased knee flexion extension range reduced peak varus angle increased peak flexion moment reduced peak valgus moment good outcome group also displayed significant increase walking speed reduction normalization stance phase duration gait cycle increased passive knee extension whereas change knee biomechanics one year surgery patients classified poor outcome significant reduction peak varus angle differences pain postoperatively found groups conclusion patients reporting good outcome knee related quality life improved knee biomechanics gait patients reporting poor outcome despite similar reduction pain remained unchanged knee biomechanics one year total knee arthroplasty regards surgeon controlled biomechanical factors surgery may successfully address frontal plane knee alignment however achieving good outcome patient reported knee related quality life may related dynamic improvements sagittal plane
common germline single nucleotide polymorphisms snps jak locus associated myeloproliferative neoplasms mpn germline sequence variant tert related risk mpn suggesting complex association snps pathogenesis mpn previous study unpublished data showed high frequency distribution genotype ten eleven translocation tet locus one chinese familial primary myelofibrosis present study evaluate role clinical significance genotype jakvf positive sporadic mpn tet genotype higher incidence jakvf positive sporadic mpn patients normal controls predisposing mpn odds ratio mpn patients genotype increased leukocyte platelets counts elevated hemoglobin concentration comparison genotype thrombotic events common mpn patients genotype confirmed genotype downregulated tet mrna transcription mechanism may involved disruption interaction ccaat enhancer binding protein alpha ebpa tet locus tet genotype stimulated erythroid hematopoiesis mpn patients altogether found novel hereditary susceptible factor tet variant development mpn suggesting variant may partially responsible pathogenesis accumulation mpn
subjective aha experience problem solvers often report find solution taken marker insight aha closely linked insightful solution processes theoretically aha experienced correct solution found however little work explored whether aha experience also accompany incorrect solutions false insights similarly although aha experience unitary construct little work explored different dimensions proposed constituents address gaps literature participants presented set difficult problems magic tricks rated solutions aha well regard suddenness emergence solution certainty correct surprise pleasure relief drive solution times also used predictors aha experience study reports three main findings first false insights exist second aha experience multidimensional consists key components pleasure suddenness certainty third although aha experiences correct incorrect solutions share three common dimensions also experienced differently regard magnitude quality correct solutions emerging faster leading stronger aha experiences higher ratings pleasure suddenness certainty solution correctness proffered slightly different emotional coloring aha experience additional perception relief correct solutions surprise incorrect ones results cast doubt assumption occurrence aha experience serve definitive signal true insight taken place hand quantitative qualitative differences experience correct incorrect solutions demonstrate aha experience mere epiphenomenon strong aha experiences clearly exclusively linked correct solutions
water situation pusey district catherine parish jamaica acute district hilly terrains made connections centralised public water supply difficult residents depend rainwater harvesting rwh systems meet potable needs like many catchments across jamaica rainwater collecting practices water use habits residents surveyed present future rwh capacity evaluated using available years rainfall data downscaled precis model climate change scenarios addition effect nino episodes rainfall patterns evaluated coefficients variations annual rainfall found higher nino years normal years two nino years rainwater harvesting capacity negatively impacted rainfall annual total lesser average annual rainfall ability rwh meet potable needs reduced based predicted shorter intense showers frequent dry spells storage tank per household persons proposed meet water demand maximum consecutive dry days january february water shortage periods design efficient rwh systems provision government subsidy storage tanks enable residents capture rainwater meet daily domestic needs
people high victim sensitivity personality trait characterized strong fear exploited others likely attend social cues associated untrustworthiness rather cues associated trustworthiness compared people low victim sensitivity people react initial expectation regarding target trustworthiness turns false results two studies show victim sensitive compared victim insensitive individuals show enhanced source memory greater change person perception negatively labeled targets violated rather confirmed negative expectations trustworthy trickster findings line recent theorizing schema inconsistency expectancy violation effects social cognition research different facets justice sensitivity personality psychology
hidradenitis suppurativa associated marked inflammatory perturbation mechanisms regulating inflammatory network remain elusive micrornas mirnas described gene regulators inflammation evaluated messenger rna mrna expression levels six selected inflammation related mirnas lesional perilesional skin samples patients healthy controls samples patients healthy controls included prospective study expression levels mirnas mirna mirna mirna mirna mirna mirna studied quantitative real time reverse transcription polymerase chain reaction observed significant overexpression mirna mirna mirna mirna mirna lesional skin compared healthy controls expression mirnas also significantly increased lesional skin compared perilesional skin mirna showed increased expression perilesional skin compared healthy controls contrast mirna significantly lower expression lesional skin compared perilesional skin found studied inflammation related mirnas significantly dysregulated lesional skin may regulatory roles inflammatory process given predicted targets functions findings point mirnas potential disease biomarkers manipulation might used therapeutically target inflammatory pathway
recent increase demand wind turbines given rise concerns availability materials used construction combination wind turbine coupled hydraulic pump instead electrical generator offers alternative application renewable energy technology article analyses dynamic response wind hydraulic system consisting wind turbine driving swash plate pump done means mathematical models utilising matlab simulink operational aspects proposed wind hydraulic pumping system validated standard baseline wind turbine model national renewable energy laboratory control issues encountered wind turbines hydraulic systems analysed wind turbine control systems used run electrical generators adopted control pressure controlled swash plate pump pump lends applications controlled varying swash plate angle thus controlling pump output power torque methods generation artificial wind data also included simple wind speed time series developed time series used test wind turbine hydraulic system varying wind conditions using concept control regions models developed show standard steady state response wind turbine together dynamic behaviour wind turbine control parameters established system also presents wind turbine controller analyses behaviour system typical extreme wind conditions study concludes system significant potential technically achievable
drawing social exchange processes leader member exchange lmx posit expressive relational schema ers instrumental relational schema irs refer knowledge structures social exchange processes act antecedents follower rated lmx specifically discuss leader follower relational schema congruence incongruence informs follower rated lmx using polynomial regression models analyze leader follower dyads test congruent incongruent effects follower rated lmx findings show ers congruence positive effect follower rated lmx irs congruence negative effect follower rated lmx results also demonstrate ers incongruence impairs follower rated lmx ers congruence irs incongruence irs congruence follower rated lmx implications lmx theory research discussed elsevier inc rights reserved
study examined whether participants could utilize study perceptual elaboration correct erroneous suggestions partner social contagion memory paradigm participants studied household scenes collaboratively recalled scenes confederate interjected erroneous items completing subsequent individual recall recognition tests participants allowed study original items generate perceptual details items across two experiments participants studied original material less likely incorporate confederate misleading suggestions study reduced false recall recognition increased veridical recall recognition experiment effect especially pronounced longer study episodes experiment items generated perceptual elaboration test offered corrective benefit beyond effects study data demonstrate participants rely self initiated correction processes engaged study reduce socially suggested false memories society applied research memory cognition published elsevier inc rights reserved
paper presents decision support system dss called dsscreening rapidly detect inborn errors metabolism iems newborn screening system created using aide framework uses techniques imported model driven software engineering mdse soft computing available eguider web portal enactment computerised clinical practice guidelines protocols mdse provides context techniques build new software artefacts based models conform specific metamodel also offers separation concern disassociate medical technological knowledge thus allowing changes one domain without affecting changes might include instance addition new disorders dss new measures computation related disorder artificial intelligence soft computing provide fuzzy logic manage uncertainty ambiguous situations fuzzy logic embedded inference system build fuzzy inference system fis specifically single input rule modules connected zero order takagi sugeno fis automatic creation fiss performed aide framework capable embedding generated fiss computerized clinical guidelines also create desktop application execute fis technologically supports addition new target languages desktop applications inclusion new ways acquiring data dsscreening tested comparing predictions results real analyses two groups samples clinical samples belonging individuals ages symptoms necessarily correspond iem system reduced time needed compared interpretation time spent laboratory professionals besides correctly classified samples obtained accuracy samples belonging individuals clinical symptoms elsevier ltd rights reserved
objective borderline personality disorder bpd high prevalence personality disorder pharmacotherapy commonly used however minority studies investigated patterns prescription bpd particularly inpatients unit aimed describe clinical features prescribing practice bpd patients investigate possible advantages single class medications combined drug treatments terms length stay hospital methods retrospective observational study evaluating bpd inpatients june june results evidence extensive use drugs benzodiazepines hypnotics antipsychotics mood stabilizers antidepressants polypharmacy common longer length stay hospital associated prescription antipsychotic antidepressant medication shorter hospitalization associated use mood stabilizer conclusions rates prescription different classes drugs reported sample similar naturalistic studies highlight heterogeneous pattern prescriptions bpd mood stabilizers showed favourable profile terms length stay hospital antipsychotic antidepressant results reiterate discrepancy international recommendations everyday clinical practice
misperception aggressive cues considered risk factor inducing adolescent aggression poor coping life stress also considered major influence aggression current study examined relationship subjective sense control adolescent aggression considering influences upon perception aggressive cues study participants took part sense control high sense control low sense control aggressive cue aggressive neutral subjects contextual experiment result found lower sense control led increase adolescents aggression low sense control condition exposure aggressive cues boost aggression study catalytic effect aggressive cues explored experiment adolescents randomly assigned low high sense control condition test importance aggressive cues results suggest adolescents low sense control condition show higher salience aggressive cues
significant association exists adults expressivity facial attractiveness unclear whether association linear significant extremes attractiveness also unclear whether attractive persons actually display positive expressivity unattractive persons target effects whether high low attractiveness influences expressivity valence judgments perceiver effects experiment demonstrated adult ratings attractiveness predictive expressivity valence high low attractive females medium attractive males experiment showed low attractive females actually display negative expressivity medium high attractive females target effects males also attractiveness influenced expressivity valence judgments perceiver effects females males findings demonstrate low attractive females particular disadvantage social interactions due low attractiveness actual displays negative expressivity perceptions negative expressivity elsevier inc rights reserved
obesity increasing prevalence across sectors society constellation associated ailments including hypertension type diabetes eating disorders melanocortin system critical neural system underlying control body weight functions deficits melanocortin system may promote exacerbate comorbidities obesity system therefore generated great interest potential target treatment obesity however drugs targeting melanocortin receptors plagued problematic side effects including undesirable increases sympathetic nervous system activity heart rate blood pressure circumnavigating roadblock require clearer picture precise neural circuits mediate functions melanocortins recent novel experimental approaches significantly advanced understanding pathways review latest advances understanding role melanocortins food intake reward pathways blood pressure glucose control energy expenditure evidence suggests downstream melanocortin responsive circuits responsible different physiological actions diverge ultimately complete understanding melanocortin pathways myriad roles allow treatments tailored mix metabolic disorders individual patient author published karger basel
decades pid proportional integral derivative like controllers successfully used academia industry many kinds plants thanks simplicity suitable performance linear linearized plants certain conditions nonlinear ones number pid controller gains tuning approaches proposed literature last decades line techniques however cases wherein plants subject continuous parametric changes external disturbances online gains tuning desirable choice case modular underwater rovs remotely operated vehicles parameters weight buoyancy added mass among others change according tool fitted practice amount time dedicated tune pid gains rov best set gains achieved rov ready work however vehicle changes tool subject ocean currents performance deteriorates since fixed set gains longer valid new conditions thus online pid gains tuning algorithm implemented overcome problem paper auto tune pid like controller based neural networks proposed plays role automatically estimating suitable set pid gains achieves stability system adjusts online controller gains attain smaller position tracking error simulation results given considering underactuated dof degrees freedom underwater rov real time experiments underactuated mini rov conducted show effectiveness proposed scheme
paper develops grounded theory receiving respect work enables individuals engage positive identity transformation resulting personal work related outcomes company employs inmates state prison perform professional business business marketing services provided unique context data collection data indicate inmates experienced respect two distinct ways generalized particularized initiated identity decoupling process allowed distinguish inmate identity desired future selves construct transitional identities facilitated positive change social context organization provided opportunities personal social identities claimed respected granted producing social validation enabling individuals feel secure transitional identities find security personal identities produces primarily performance related outcomes whereas security company identity produces primarily well related outcomes two types security together foster integration seemingly incompatible identities identity holism employees progress toward becoming desired selves work suggests organizations play generative role improving lives members respect based processes
high rates psychotic disorder among special populations homicide offenders females youth mentally disordered received much investigation personality disorder especially antisocial personality disorder augments relative risk ratio violence especially combination substance use disorder studies correlates violence especially homicide reported low medium income countries lmic using structured clinical interview dsm diagnosis scid personality disorders identified cross sectional study involving homicide offenders jimma prison ethiopia predictors personality disorder determined using multivariate analysis various demographic clinical variables example age psychiatric history substance use offenders completed scid fulfilled dsm criteria personality disorder rationale killing self defence anger revenge offenders planning involved offending reasonably high level relationship functioning married different data high income countries diagnostically relevant cultural factors lmic play high income countries may explain differences personality disorders similar mental disorders underlying mediators homicide
paper presents digital control technique achieve valley switching bidirectional flyback converter used drive dielectric electroactive polymer based capacitive incremental actuator paper also provides design low input voltage variable high output voltage bidirectional flyback converter driving capacitive incremental actuator incremental actuator consists three electrically isolated mechanically connected capacitive actuators requires three high voltage bidirectional converters accomplish incremental motion charging discharging capacitive actuators bidirectional flyback converter employs digital controller improve efficiency charge discharge speed using valley switching technique charge discharge processes without need sense signals output side experimental results verifying bidirectional operation flyback converter presented using polypropylene film capacitor load energy loss distributions converter presented mosfets used side flyback prototype mosfet demonstrated charge energy efficiency charge capacitive load discharge energy efficiency discharge
honey established traditional medicine variety putative nutritional health effects including antibacterial antioxidant anti inflammatory prebiotic aim present study investigate safety consuming manuka honey umf healthy individuals establishing whether umf caused allergic response measured ige levels changed major commensal beneficial microbial groups gut affected levels one common advanced glycation endpoints epsilon carboxymethyl lysine cml study randomised double blind cross design total twenty healthy individuals aged years recruited tested two different honeys multiflora honey umf produced comvita new zealand ltd puke new zealand multiflora honey umf consumed daily weeks week washout period blood samples collected every week intervention period used measure total ige levels serum advanced glycation endproducts consequence methyglyoxal accumulation faecal samples collected beginning end week period dna extracted faecal samples levels number microbial groups gut beneficial commensal analysed neither product changed levels ige cml altered lint microbial profiles trial confirming umf safe healthy individuals consume despite anecdotal evidence suggesting manuka honey good digestive health observed beneficial effects lower gut bacterial levels either honey healthy population
idiopathic pulmonary fibrosis ipf age related multifactorial disease featuring non uniform lung fibrosis decisive cellular events early stages ipf poorly understood involvement club cells ipf pathogenesis unclear migration associated lung fibrosis study labeled club cells immunohistochemically ipf lungs using club cell marker claudin cldn unique protein based recent report demonstrated appearance cldn developing repairing lungs precedes club cell markers including club cell secretory protein ccsp cldn positive cells ipf lungs displayed marked pleomorphism found varied arrangements suggesting phenoconversion results corroborated immunogold labeling cldn immunohistochemical double labeling cldn alpha smooth muscle actin alpha sma demonstrated aberrant alpha sma signals frequently encountered near disorganized cldn positive cells hyperplastic bronchiolar epithelium thickened interstitium ipf lungs collectively data indicate club cells actively participate initiation progression ipf phenoconversion involving acquisition proliferative migratory abilities thus new findings open possibility club cell targeted therapy become strategic option treatment ipf
mobile hoc network manet type wireless network consisting set self configured mobile hosts communicate using wireless links without assistance fixed infrastructure made possible create distributed mobile computing application also brought several new challenges distributed algorithm design checkpointing well explored fault tolerance technique wired cellular mobile networks however directly applicable manet due dynamic topology limited availability stable storage partitioning absence fixed infrastructure paper propose adaptive coordinated non blocking checkpointing algorithm provide fault tolerance cluster based manet minimum number mobile hosts cluster take checkpoints performance analysis simulation results show proposed scheme performs well compared works related authors published elsevier
present novel method data protection resolve issue mass tampered regions image watermarks approach involves asymmetric cryptography follows nonspatial domain technique codebook exists public key verification code exists private key two major components study self recovery images sparse approximation specifically generate self recovery images basis previous research generate verification codes mark data maximum coefficient resulting sparse approximation approach processes blocks given images results demonstrate block processed sparse approximation algorithm main texture feature associated codeword higher sparse coefficient value codebook provides robust method protect data via watermarking verify copyright data proposed method efficiently supports compression transmission via popular communication applications using method common conditions confirmed outstanding unit correction rate approximately especially crop attacked images
objectiveschizophrenia may result failure normal lateralization process brain however whole brain asymmetry assessed date propose novel measure global brain asymmetry based dice coefficient quantify similarity brain hemispheres methodglobal gray white matter asymmetry calculated high resolution structural images acquired patients schizophrenia healthy controls age sex matched analyses replicated much larger sample obtained open access online databases resultspatients schizophrenia global gray matter asymmetry controls additionally increased gray matter asymmetry associated avolition whereas inverse relationship found anxiety trend level analyses replicated larger sample confirmed previous results conclusionour findings suggest global gray matter asymmetry related concept developmental stability useful indicator perturbations neurodevelopment
endophenotypes disease associated phenotypes thought reflect neurobiological mechanisms underlie overt symptoms psychiatric illness endophenotypes critical understanding genetics neurobiology treatment schizophrenia psychiatric illnesses multiple causes including genetic nongenetic risk factors endophenotype linked one mechanisms may expressed frequently disease however schizophrenia research endophenotypes almost exclusively studied older adolescents adults entered passed age risk disorder yet schizophrenia neurodevelopmental disorder prenatal development starts cascade brain changes across lifespan endophenotypes minimally utilized explore perinatal development vulnerability one major impediment development perinatally useful endophenotypes established validity criteria example criterion endophenotype frequently present disease without difficult demonstrate decades long period endophenotype measurement age greatest risk onset disorder article proposes changes endophenotype validity criteria appropriate perinatal research reviews application modified criteria helped identify perinatally usable phenotype risk schizophrenia sensory gating used propose novel perinatal primary prevention intervention
since industrial processes wide range operating conditions difficult build single global model describes process one solution widely used control engineering practice combine multiple models based collected process data approach successful important cluster data modeling study pairwise constraints active learning method incorporated affinity propagation algorithm resulting new method called active semi supervised affinity propagation assap clustering apply assap modeling industrial processes active learning strategy firstly used obtain constraints data based angle change two data points probability belonging class constraints used adjust clustering process improve clustering precision finally least squares support vector machine svm used build submodel cluster data points sub models integrated model whole data set verification assap method carried data uci university california irvine machine learning repository olivetti dataset addition assap svm combined applied data combustion process coke oven result shows effectiveness method modeling complex industrial process based assap published elsevier ltd
course sexual development many people experience dissonance dimensions sexual orientation including attraction behavior identity study assesses relationship sexual orientation discordance mental health data obtained national longitudinal study adolescent adult health female non hispanic black hispanic race non white multivariable linear regression evaluated correlation sexual orientation discordance perceived stress depressive symptomatology models stratified sex sexual identity among self identified heterosexual females mostly heterosexual males sexual orientation discordance predicted significantly increased depressive symptomatology subpopulation demonstrated significant correlation sexual orientation discordance depressive symptomatology perceived stress association sexual orientation discordance depressive symptomatology suggests link sexuality self concept mental health
background purpose study elucidate effects dual coated probiotic supplement duolac care symptoms diarrhea predominant irritable bowel syndrome randomized double blind clinical trial methods fifty subjects diarrhea predominant irritable bowel syndrome randomly assigned either non coating group dual coating group order receive two capsules per day multi species probiotics containing billion bacteria per capsule weeks data adequate relief questionnaire used assessment primary outcome daily records stool frequencies bristol stool scale weekly symptom diary using visual analog scale beck depression inventories collected blood tests including blood cell counts interleukin tumor necrosis factoralpha inducible nitric oxide synthase regulatory cells high cells lap cells high lap cells analyzed study shift gut microbiota investigated using quantitative real time polymerase chain reaction assay results responses adequate relief questionnaire indicated significant improvement overall discomfort dual coating group ratio normal stools hard watery stools better effect dual coated probiotics compared non coated probiotics may due shift intestinal microbiota correlation analysis showed significant negative correlation bifidobacterium urgency defecation conclusions result implies dual coating layers probiotic supplement candidate treatment diarrhea predominant irritable bowel syndrome
objectives study focuses facilitation clients psychosocial communication prenatal counseling fetal anomaly screening assessed psychosocial communication clients related midwives psychosocial affective communication client directed gaze counseling duration methods videotaped prenatal counseling consultations dutch midwives verbal psychosocial affective behavior measured roter interaction analysis system rias rated duration client directed gaze performed multilevel analyses assess relation clients psychosocial communication midwives psychosocial affective communication client directed gaze counseling duration results clients psychosocial communication higher midwives asked psychosocial questions showed affective behavior beta beta respectively clients psychosocial communication related midwives client directed gaze additionally psychosocial communication clients directly positively related counseling duration beta conclusions contrast expectations midwives client directed gaze related psychosocial communication clients practice implications addition asking psychosocial questions study shows midwives affective behavior counseling duration likely encourage client psychosocial communication known especially important facilitating decision making authors published elsevier ireland ltd open access article ncnd license http creativecommons org licenses
article discussed application fly ash building materials engineering farm industry aspects detail last analyzed future application
due low residual flux density ferrite magnets flux focusing multi layer configurations deployed harness permanent magnet torque reluctance torque new configuration featuring spoke rotor structure embracing combined configuration conventional spoke shaped interior permanent magnet ipm machines proposed superior torque density equivalent counterparts magnetic open circuit characteristic spoke machine first analysed compared equivalent spoke shaped machines finite element analysis fea simulations performed load conditions confirm superior performance proposed design frozen permeability method carried provide insights torque production mechanism operating efficiency torque profiles power speed performance also investigated evaluated confirm utility proposed ferrite machine design
polysaccharides extracted pleurotus eryngii peps streptococcus thermophilus ascc eps sulphonated composition determined antioxidant activities crude sulphonated polysaccharides peps eps investigated using abts radical scavenging test ccd caco cell models degrees sulphonation peps eps respectively results showed peps eps significantly higher scavenging capacities peps eps abts radical scavenging test reactive oxygen species malondialdehyde treated ccd con ccd caco cells significantly inhibited peps eps peps eps compared control group additionally peps eps significantly improved superoxide dismutase catalase glutathione peroxidase activities treated ccd caco cells compared peps eps control groups results indicated sulphonation effective improving antioxidant activities peps eps elsevier ltd rights reserved
electrical analogy used solve numerical problems fluid mechanics used solve classical problem couette flow two parallel plates hagen poiseuille flow pipe transient free convection flow along semi infinite vertical wall nonlinear system partial differential equations numerically solved network simulation method based thermo electric analogy simulator electrical devices permits direct visualization local integrated transport variables temperatures velocities concentrations fluxes point section medium time solution transient steady state problems obtained requirement finite difference schemes spatial variable educational tool seen useful solving numerical problems engineering used graduate university wiley periodicals inc comput appl eng educ
introduction determine benefits healing therapy spiritual healing adjunct conventional management irritable bowel syndrome ibs inflammatory bowel disease ibd methods outpatients ibs ibd randomised either conventional treatment control conventional plus five sessions healing therapy intervention weeks controls also healing therapy outcomes used measure medical outcomes profile mymop ibs qol ibdq symptom measures results significant improvement mymop score week maintained week improvements mymop significantly greater intervention group weeks effect sizes condition specific data ibs showed qol dimensions significant minimum point score improvement weeks overall score improvement units week units week units week ibd also similar score improvement week associations improved social bowel functions respectively group differences identified qol scores ibs week week ibd group conclusions addition healing therapy conventional treatment associated improvement symptoms qol ibs lesser extent ibd authors published elsevier gmbh
divisible cash systems allow users withdraw unique coin value units bank spend several times distinct merchants system whereas users want anonymity transactions bank wants prevent least detect double spending trace defrauders primitive introduced two decades ago quite really anonymous constructions proposed addition one proven secure random oracle model still either weak security models quite complex settings thus costly constructions unique proposal secure standard model appeared recently unpractical evidence authors left construction efficient scheme secure model open problem study authors answer first efficient divisible cash system secure standard model based new way building coins unique public global tree structure coins actually propose two constructions offer tradeoff efficiency security achieve constant time withdrawing spending amounts units allowing bank quickly detect double spendings simple comparison serial numbers deposited coins ones previously spent coins
bacterial ribosome many functional ribosomal rna rrna sites computationally analyzed rrna regions involved interactions subunits various properties rrna solvent accessibility opening energy hydrogen bonding pattern van der waals energy thermodynamic stability determined based properties selected rrna targets hybridization complementary methyl oligoribonucleotides ome rnas inhibition efficiencies designed ribosome interfering ome rnas tested using beta galactosidase assay translation system based coli extract several oligonucleotides displayed values similar range determined known ribosome inhibitors tetracycline pactamycin calculated opening van der waals stacking energies rrna targets correlated best inhibitory efficiencies ome rnas moreover binding affinities several oligonucleotides ribosomes isolated subunits measured using doublefilter retention assay applied heat shock chemical transformation introduce ome rnas coli cells verify inhibition bacterial growth observed high correlation cell free extract bacterial growth inhibition overall results suggest computational analysis potential rrna targets within conformationally dynamic regions inter subunit bridges help design efficient antisense oligomers probe ribosome function
morality prominent guide action perception argue non emotional gestures prime abstract concept honesty four studies demonstrated emblematic gesture associated honesty putting hand one heart increased level honesty perceived others increased honesty shown one behavior target persons performing gesture described terms associated honesty appeared trustworthy others targets photographed control gesture persons performing hand heart gesture provided honest assessments others attractiveness refrained cheating compared persons performing neutral gestures findings suggest bodily experience associated abstract concepts influence one perceptions others one complex actions findings suggest influence mediated changes affective states
investments european structural funds pursue goals smart inclusive sustainable growth many towns cities europe shrinking rather growing policy makers practitioners therefore face challenges ensuring places limited growth potential fall behind scholars argue cities long term decline would benefit enhancing capacity develop collaborative initiatives draw local resources assets practice local decision makers seem struggle engage communities fight causes consequences decline paper advances argument concept production well suited explore explain collaborative actions unlock new strategic choices based capabilities resources local actors control case study small manufacturing town germany used illustrate production different levels lead tangible long term improvements context ongoing shrinkage
increasing demand complex distributed software calls novel software engineering methods techniques create systems able autonomously adapt dynamically changing situations paper present framework engineering requirements adaptive software systems approach called troposas combines goal oriented concepts high variability design methods troposas requirements model directly mapped software prototypes agent oriented architecture executed requirements validation refinement give comprehensive description framework conceptual models modelling guidelines supporting tools applicability framework requirements validation refinement illustrated case study two controlled experiments subjects provide empirical evaluation proposed modelling language statistical evidence effectiveness modelling approach gathering requirements adaptive systems
direct model predictive power control dmppc emerged viable alternative grid tied active front end afe power converters however one switching vectorper sampling interval character leads big ripples control variables work proposes performance enhanced direct multiple vector model predictive power control dmv mppc solution grid tied afes directly implementable fpga proposed control scheme compared classical dmppc presented experimental results illustrate control performance significantly improved proposed dmv mppc scheme
examine transient evolution negatively buoyant laminar plume emptying filling box containing uniform porous medium long time limit tau infinity box partitioned two uniform layers different densities however approach towards steady state characterized lower contaminated layer continuously stratified presence continuous stratification poses non trivial analytical challenges nonetheless demonstrate possible derive meaningful bounds range possible solutions particularly limit large represents ratio draining filling time scales validity approach confirmed drawing comparisons free turbulent plume case unlike porous media plumes analytical solution accounts time variable continuous stratification lower layer available baines turner fluid mech vol germeles fluid mech vol separate component study considers time variable forcing laminar plume source strength changes abruptly time source turned half period delta tau depth reduced gravity contaminated layer oscillate two extrema first cycles different behaviour seen source merely turned instance change source reduced gravity leads permanent change interface depth qualitative point difference free turbulent plume case
purpose review update healthcare providers potential contribution increased basal metabolic rate hypermetabolism low testosterone development weight loss cancer patients recent findings cancer cachexia loss skeletal muscle without loss fat multifactorial syndrome wide variation frequency hypermetabolism exists cancer patients accurately identified indirect calorimeter frequency hypermetabolism increases depending histology stage tumor associated presence acute inflammatory response often accompanied weight loss hypogonadism result chemotherapy radiation treatment use opioids treat chronic pain frequently noted male cancer patients reported also associated anorexia weight loss summary cancer patients may develop weight loss cachexia distressing patients family treatments directed reducing basal metabolic rate supplementation testosterone hypogonadic male patients may potential improve lean body mass research needed
wind energy many advantages pollute inexhaustible source however evaluation control schemes electrical generator hard wind turbine since wind speed varies similar environment turbine wind turbine emulator wte used purpose wind energy systemsis tomaximize energy efficiency extract maximum power wind speed words power coefficientis maximum therefore maximum power point tracking case mppt control becomes important realize control strategy conventional proportional integral controller usually used however strategy achieve better performance paper proposes robust control turbine optimizes production improve quality energy efficiency namely strategy sliding mode control proposed sliding mode control strategy presents attractive features robustness parametric uncertainties turbine proposed sliding mode control approach applied wind turbine emulator matlab simulink
present work total energy equivalence hypothesis applied constitutive modeling engineering materials approach originally developed damaged materials extended modeling damage also dissipative phenomena like phase transformation consistent manner proposed model examined means parametric studies show ability reflect different experimentally observed features real materials
background context lack information postoperative outcomes related risk factors associated spinal surgery patients parkinson disease purpose study aimed investigate postoperative morbidity mortality associated spinal surgery patients risk factors poor outcomes study design retrospective matched pair cohort study patient sample data patients underwent elective spinal surgery july march extracted diagnosis procedure combination database nationwide inpatient database japan outcome measures hospital mortality occurrence postoperative complications methods patient randomly selected four age sex matched controls hospital year differences hospital mortality occurrence postoperative complications compared patients controls multivariable logistic regression model fitted generalized estimation equation used identify significant predictors major complications surgical site infection sepsis pulmonary embolism respiratory complications cardiac events stroke renal failure multiple imputation used missing data results among patients undergoing spinal surgery patients matched controls identified crude hospital mortality higher patients controls respectively crude proportion major complications also higher patients controls postoperative delirium common patients controls parkinson disease significant predictor major postoperative complications even adjusting risk factors odds ratio confidence intervals conclusions patients significantly increased risk postoperative complications following spinal surgery postoperative delirium frequently observed complication elsevier inc rights reserved
mathematical model emissions developed twingo engine effects variations compression ratio fuel air equivalence ratio spark advanced combustion duration pollutant emissions studied analysis data collection performed engine bank using data acquisition system integrated interactive engineering environment control strategy implemented guarantee emissions reduction
background although asthma attacks known adverse events associated nonsteroidal anti inflammatory drug nsaid use studies quantified risks objectives study utilize epidemiological approach quantitatively evaluate risk acute asthma attacks associated nsaid prescription japan compare risks among nsaids according cyclooxygenase cox selectivity methods conducted self controlled case series study using japanese health insurance claims data exposed cases identified experienced nsaid prescription acute asthma attack defined combination inhalation procedure prescription inhaled agonist incidence rate ratios irrs confidence intervals cis nsaid prescription periods compared baseline periods calculated using conditional poisson regression models cox selective nonselective nsaids similarly compared results identified subjects younger years significantly higher risk acute asthma attacks nsaid prescription period compared baseline period quantified irrs descending order prescription start date days prescription start date days prescription end date days prescription start date days prescription start date lower asthmatic risks cox selective nsaids compared nonselective nsaids conclusions use nsaids japan associated increased risk acute asthma attacks however risk lower cox selective nsaids
increase urban population high rise buildings widely applied foundation basis building quality directly relative safety building according practical example foundation engineering high rise building paper established parameterized model foundation engineering bim technology simulated whole process foundation construction quickly complete transmission construction information accomplished cooperative work platform bim afterward collision detections reinforcement clearance done catch collision problems reinforcements joints early time compared traditional construction management method found application bim technology control construction quality effectively optimize resource allocation ensure safety foundation engineering
introduction polycythemia vera one common forms myeloproliferative neoplasms acute myeloid leukemia secondary well reported mechanism clarified extent limited number cases reported development acute lymphoblastic leukemia course possible underlying mechanism explored well case presentation year old patient developed years diagnosed presence remarkable splenomegaly typical immunophenotyping peripheral blood increased expression serum fibrosis markers indicated existence extramedullary hematopoiesis may ascribe myelofibrosis treatment dosage modulated chemotherapy patient got complete remission conclusion jak mutation may underlying factor contributes development existence may indicate progression post polycythemic may risk factor accelerated transformation
risk prevention measures put forward vehicle burning operating periods three tower four span suspension bridge combining characteristics bridge vehicle burning accident article set traffic reporting system tankers bridge determined report system tankers across bridge tankers passed middle lane near median guidance bridge manager significant indicators set ends bridge vehicles could shunt rapidly extreme fire conditions department public security fire control transportation bridges management center get together establish accident emergency rescue leading group formulated security system fire resistance rescue organization yingwuzhou yangtze river bridge video monitoring alarm system fire control facilities set side pier side tower middle main span middle tower provided reliable prevention measures bridge operation
forward quantification simulation code response uncertainties requires knowledge physical model parameter uncertainties nuclear thermal hydraulics codes relap trace provide information uncertainties physical model parameters framework developed quantify uncertainties physical model parameters using maximum likelihood estimation mle bayesian maximum priori map markov chain monte carlo mcmc algorithms objective present work perform sensitivity analysis physical model parameters code trace calculate uncertainties using mle map mcmc algorithms oecd nea bwr full size fine mesh bundle test bfbt data used quantify uncertainty selected physical models trace code bfbt based multi rod assembly measured data available single two phase pressure drop axial radial void fraction distributions critical power wide range system conditions work steady state cross sectional averaged void fraction distribution used input data inverse uncertainty quantification iuq algorithms selected physical model probability distribution function pdf desired output quantity elsevier ltd rights reserved
vanadium dioxide promising multifunctional smart material shown strong promise microactuation memory optical applications thermally induced insulator metal phase transition changes electrical mechanical optical properties demonstrate pronounced complex hysteresis respect temperature presents challenge utilization material paper extended generalized prandtl ishlinskii model proposed model hysteresis nonlinear memoryless function introduced improve modeling capability novel inverse compensation algorithm hysteresis model developed based fixed point iteration convergence conditions algorithm derived proposed approach shown effective modeling compensating asymmetric non monotonic hysteresis saturation curvature output temperature input coated microactuator well asymmetric hysteresis partial saturation resistance output temperature input film
article presents three successful case studies oriented disabled dependent people three case studies results following corresponding projects autonomous agent monitoring alzheimer patients agalz facilitates monitoring tracking patients alzheimer azteca formed set tools facilitate work disabled people work environment movi mas simulates work environment enabling detection dangerous situations tools developed using agent platform called pangea platform develop open multi agent systems specifically including organizational aspects virtual agent organizations
paper novel effective approach automated audio classification presented based fusion different sets features visual acoustic number different acoustic visual features sounds evaluated compared features fused ensemble produces better classification accuracy state art approaches visual features sounds built starting audio file taken images constructed different spectrograms gammatonegram rhythm image images divided sub windows set texture descriptors extracted feature descriptor different support vector machine svm trained svms outputs summed final decision proposed ensemble evaluated three well known databases music genre classification latin music database ismir database gtzan genre collection dataset bird vocalization aiming specie recognition dataset right whale calls aiming whale detection mat lab code ensemble classifiers extraction features publicly available https www delunipclit node pattern recognition ensemble classifiers elsevier rights reserved
psychology antarctic explorers groups antarctic bases much studied recent years current knowledge summarized review palinkas suedenfeld formal psychological research heroic age antarctic exploration number doctors non medical personnel expeditions keen observers psychological aspects expeditions wrote paper describe understanding psychology antarctic exploration comparing current knowledge clear found formal study known explorers heroic age
study sought determine evaluation current pre morbid personality traits alzheimer disease well personality changes psychodynamic framework sidney blatt personality developmental perspective anaclitic introjective taken references study conducted four groups assessed using depressive experiences questionnaire mainly form individual interview sessions current personality measure alzheimer disease group consisting female participants age years control group consisting female participants population large age years pre morbid personality measure alzheimer disease group informants control group informants results line psychodynamic literature review provide new research data findings suggest stability across life cycle relatedness anaclitic dependency personality style dementia implications findings future research discussed elsevier ltd rights reserved
compared understanding neurocognitive processes involved producing mimicry downstream consequences mimicked less clear wide variety positive consequences mimicry liking helping reported behavioural research however depth review suggests link mimicry liking positive outcomes may fragile positive responses mimicry break due individual factors social situations mimicry may unexpected remains unclear complex behavioural effects mimicry relate neural systems respond mimicked mimicry activates regions associated mirror properties self processing reward review outline three potential models linking regions cognitive consequences mimicked models suggest positive downstream consequences mimicry may depend upon self overlap detection contingency low prediction error finally highlight limitations traditional research designs suggest alternative methods achieving highly ecological validity experimental control also highlight unanswered questions may guide future research elsevier ltd rights reserved
advanced communication technologies allowed power line communication plc channel transmission medium enables transfer high speed digital data classical indoor electrical wires development plc systems internet voice data services requires measurement based models transfer characteristics mains network suitable performance analysis simulation paper presents impact load impedances connected electrical network insertion gain capacity plc link
contribution obtain nonlinear controller class nonlinear time delay systems using inverse optimality approach avoid solution hamilton jacobi bellman type equation determination bellman functional extending inverse optimality approach delay free nonlinear systems time delay nonlinear systems achieved combining control lyapunov function framework lyapunov krasovskii functionals complete type explicit formulas optimal control obtained efficiency proposed method illustrated via experimental results applied dehydration process whose model includes delayed state linear part delayed nonlinear part give evidence good performance proposed control law experimental comparison industrial proportional integral derivative controller optimal linear controller additionally experimental robustness tests presented elsevier ltd rights reserved
strong economic growth recent years led intensive use natural resources causes environmental stress well restrictions availability resources therefore efficient use resources necessary important contribution sustainable development essenz method presented article comprehensively assesses product resource efficiency going beyond existing approaches considering pollution environment well physical socio economic availability resources paper contains short description essenz methodology well case study mercedes benz class comparing conventional petrol engine plug hybrid electric motor petrol engine applying essenz method shown use different materials plug hybrid influences dimensions physical socio economic availability significantly however environmental impacts especially climate change summer smog clear advantages occur due lower demand fossil energy carriers shown within case study applying essenz method comprehensive evaluation used materials fossil energy carriers achieved
objective compare clinical characteristics cervical spine trauma patients ankylosing spondylitis cervical ossification posterior longitudinal ligament opll control group methods total patients cervical spine trauma january december reviewed fourteen patients diagnosed patients diagnosed opll patients controls spine plain radiography computed tomography magnetic resonance imaging obtained evaluation cervical spine trauma american spinal injury association impairment scale subaxial cervical spine injury classification used evaluate neurologic status patients fracture mechanism results patients opll spinal injuries associated minor trauma control group patients spinal fracture injuries cervical spine trauma patients opll mostly spinal cord injuries without bony fractures cervical spine trauma delayed diagnosis occurred patients patients opll improvement neurologic deficit treatment showed better outcomes patients opll controls conclusions patients opll cervical spine trauma showed different characteristics outcomes control patients proper surgical treatment led better outcomes patients patients opll control patients moreover important thoroughly examine patients opll cervical trauma delay diagnosis
cell culture three dimensional hollow cylindrical porous scaffolds radial flow packed bed bioreactors rpbbs advantages static culture axial perfusion bioreactors transport models rpbbs tissue engineering proposed thus far neglect effect fluid dynamics bioreactor void spaces radial flux maldistribution although effect proven important industrial reactors paper two dimensional axisymmetric model proposed steady state momentum transport three compartments rpbbs conditions construct permeability typical tissue engineering applications transport inner hollow cavity outer peripheral annulus described according navier stokes equations darcy brinkman equation used transport across annular construct model predictions qualitatively validated literature data effects performance determining dimensionless groups radial flux distribution along bioreactor length investigated criterion proposed design operate rpbbs radial fluxes uniformly distributed along bioreactor length conditions typical tissue engineering bioreactor designs operation meeting criterion avoid non uniform development tissue structure functional properties elsevier rights reserved
research men health increasingly recognized importance depression eating disorders among men present study sought extend extant work self concept depression men incorporating muscularity related attitudes behaviors also incorporating risk disordered eating two samples one heterosexual college men one gay bisexual men sampled online recruited participants completed measures drive muscularity self concept depression symptoms eating disorder symptoms data analyzed using structural equation model relationships drive muscularity attitudes behaviors depression eating disorder symptoms mediated physical self concept global physical self concept selfesteem model supported gay bisexual men sample college men sample implications future research men integration body related variables therapy men discussed
research simplified approach based size effect theory used extrapolate strength values obtained small asphalt mixtures specimens low temperature modified bending beam rheometer bbr first nine asphalt mixtures different mix designs prepared weibull statistics factorial design used evaluate statistical distribution bbr measurements effect conditioning time loading rate testing temperature material response respectively finally bbr strength measured three different temperatures compared corresponding values obtained two conventional test methods direct tension indirect tension idt tests observed bbr strength values statistically equivalent idt size effect theory weakest link model used take account difference volume geometry stress field across three testing methods american society civil engineers
background common understanding needs emergency department frequent users differ patients study sought examine best serve population examinations frequent users present barriers care exist service offerings may help patients achieve optimal level health conducted methods performed prospective study frequent users adult level trauma center approximately visits per year frequent users defined make four visits month period participants administered piloted structured interview trained researcher querying demographics usage perceived barriers care potential aids maintaining health results screened patients identified frequent users one hundred frequent users enrolled mean age years majority subjects female white insured medicaid medicare subjects median visits inpatient admissions past months hospital frequent users stated primary reason visit felt health problem could treated transportation presented major barrier patients subjects stated hours options besides minor health issues nurse work one one help manage health care needs would helpful achieving optimal health conclusion study characterized frequent users identified several opportunities better serve population understanding barriers care patient perspective health systems potentially address unmet needs prevent wellness population
background considerable body evidence suggest behavioural activation depression equally effective less complex treatment cognitive behavioural therapy may therefore suitable cognitively impaired early stage dementia mild cognitive impairment learning disability materials methods case study presented outlines behavioural approach used support older adult learning disability mild cognitive impairment depressed delivered carer liaison practitioner employed memory service results client score gds reduced gas indicating clinically significant improvement symptoms depression anxiety post treatment mood ratings ottawa mood scales rose increased engagement activities improvement client problem solving abilities evident conclusions case study demonstrates clinical utility behavioural activation treatment depression older adult learning disability mild cognitive impairment matches findings studies behavioural activation intervention treat depression older adults however client formal diagnosis learning disability may therefore atypical comprehensive studies including randomised controlled trials needed confirm findings thoroughly test effectiveness behavioural interventions client group
background health mothers newborns intricately related weight infant birth powerful predictor infant growth survival considered partly dependent maternal health nutrition pregnancy conducted longitudinal study urban community within karachi determine maternal predictors newborn birth weight methods four hundred pregnant women enrolled study period data related symptoms acute respiratory illness fever cough difficulty breathing runny nose sore throat headache chills myalgia lethargy pregnant women collected weekly delivery birth weight newborn recorded within days delivery weight classified low birth weight lbw results total symptom episodes recorded fever cough difficulty breathing runny nose sore throat headache chills myalgias lethargy enrolled pregnant women study pregnant women whose newborns weighed within days birth lbw proportion multivariate analysis independent significant risk factors noted delivering lbw babies early pregnancy weight odds ratio adjusted oradj gestational age oradj every one week increase gestational age among mothers high socioeconomic status ses every unit increase number episodes respiratory illness weeks pregnancy trend association increased risk delivering lbw infants oradj however among mothers belonging low ses association number episodes maternal respiratory illness pregnancy infants lbw oradj conclusions overall respiratory illnesses pregnancy impact newborn weight study found trend sub group mothers belonging higher ses whether mothers belonging lower ses effects respiratory illnesses overshadowed risk factors associated poverty need studied
high power white light emitting diodes leds attracted much attention due versatility variety applications growing demand markets general lighting automotive lamps communications devices medical devices particular need high reliability long lifetime poses new challenges research development production application led lighting accurate effective prediction lifetime reliability led lighting emerged one key issues solid state lighting field prognostic engineering technology predicts future reliability determines remaining useful lifetime product assessing extent deviation degradation product expected normal operating conditions prognostics bring benefits led developers users optimizing system design shortening qualification test times enabling condition based maintenance led based systems providing information return investment analysis paper provides overview prognostic methods models applied led devices led systems especially use long term operational conditions methods include statistical regression static bayesian network kalman filtering particle filtering artificial neural network physics based methods general concepts main features methods advantages disadvantages applying methods well led application case studies discussed fundamental issues prognostics photoelectrothermal theory led systems also discussed clear understanding reliability lifetime concepts leds finally challenges opportunities developing effective prognostic techniques addressed
paper describes successful application pilot sensors groyne alongside yellow river near dayulan aim innovative application sensors create real time monitoring system used monitoring system designed based knowledge gained dutch ijkdijk project ijkdijk dutch word calibration levee deployed sensors tri axialy mems micro electrical mechanical systems optical glass fibre system geotextile management system readymind links sensor output dike stability analysis model provides gis based interface offering continuous status information dike stability system also provides sophisticated simulation capability operational support offering benefits areas emergency response planning crisis management
two well known problems recognizing faces presence facial expression variation presence occlusion humans depict feelings facial expressions effective way nonverbal communication facial expressions dynamic recognizing faces varying facial expressions thus challenging task ability recognize human affective state intelligent machine empower interpret understand respond human emotions moods possibly intentions similar one person another hand occlusion image refers obstructions view object face recognition systems real world applications need manage extensive variety obstructions faces occluded facial accessories sunglasses scarf cap cloak objects face hand food cellular telephone extreme illumination shadow self occlusion non frontal pose poor picture quality blurring paper perform comparative study various state art techniques recognize faces varying facial expressions presence occlusion
background short term psychodynamic psychotherapies shown effective major depression unclear could treatment choice depressed patients many chronic complex health issues sufficiently responded treatment method superiority trial used single blind randomised parallel group design test efficacy time limited intensive short term dynamic psychotherapy istdp treatment resistant depression trd patients referred secondary care community mental health teams cmht met dsm criteria major depressive episode received antidepressant treatment weeks hamilton depression rating scale ham scores recruited effects sessions istdp judged comparison secondary care cmht treatment usual tau primary outcome ham scores months secondary outcomes included patient health questionnaire phq self report measures depression dichotomous measures remission defined ham score partial remission defined ham score results sixty patients randomised groups istdp tau data collected baseline months multi level linear regression modelling showed change time depression scales significantly greater istdp group comparison tau statistically significant group treatment differences moderate large range favouring istdp observed observer rated cohen self report measures cohen depression relative tau patients istdp group significantly likely months achieve complete remission partial remission limitations unclear results generalizable providers geographical locations cultures conclusions time limited istdp appears effective treatment option trd showing large advantages routine treatment delivered secondary care services
recent experimental work shown variations confinement butane bronsted acid sites due changes zeolite framework structure strongly affect apparent intrinsic enthalpy entropy activation cracking dehydrogenation quantum chemical calculations provided good estimates intrinsic enthalpies entropies activation extracted experimental rate data mfi extending calculations less confining zeolites proven challenging particularly activation entropies herein report efforts develop theoretical model cracking dehydrogenation butane occurring series zeolites containing ring channels differing cavity size ton fer svr mfi mel stf mww combine approach calculate intrinsic apparent activation parameters thermal corrections apparent barriers obtained configurational bias monte carlo simulations account configurational contributions due global motions transition state obtain good agreement theory experiment activation parameters central cracking zeolites terminal cracking dehydrogenation good agreement theory experiment found highest confinements experimental activation parameters especially dehydrogenation tend increase decreasing confinement trend captured theoretical calculations deviations theory experiment increase confinement decreases propose transition states dehydrogenation later cracking relative movements fragments produced reaction become increasingly important less confining zeolites
device free positioning allows localize track passive targets carrying electronic device moving area monitored dense network low power battery operated wireless sensors technology promising wide number applications ranging ambient intelligence smart spaces intrusion detection emergency rescue operations critical areas paper new approach proposed average path loss fluctuations received signal strength induced moving target jointly modeled based theory diffraction novel stochastic model derived used evaluation fundamental performance limits model proved tight enough adopted real time estimation target location proposed localization system validated extensive experimental studies indoor outdoor environments model calibration addressed practical scenarios compare performance different bayesian online localization methods test bed system supports efficient flexible target tracking without requiring action end users addition technology proven readily applicable existing ieee compliant phy layer standard adapting low level mac firmware
scouring significant problem river bank coastal protection systems severe scouring cause damaging consequences geotextile tube embankment structures study five case scenarios embankment system supported stacked geotextile tubes analyzed using commercially available finite element analysis software case scenarios include conventional geotextile tube stacking ground base foundation geotextile tube stacking gravel bedding foundation geotextile tube stacking excavated foundation geotextile tube stacking excavated foundation gravel bedding fortification stacked geotextile tubes riprap protection case scenario simulated normal loading critical loading conditions without scouring base toe embankment system results suggest potential problems occur scouring critical states embankment system instigate failures could destabilize geotextile tube retaining structure among case scenarios considered additional fortification riprap increases performance global stability geotextile tube embankment system american society civil engineers
investigate effects mediterranean type diet patients osteoarthritis ninety nine volunteers aged years completed study female southeast england participants randomly allocated dietary intervention diet control con diet group asked follow mediterranean type diet weeks whereas con group asked follow normal diet participants completed arthritis impact measurement scale aims pre mid post study period subset participants attended clinic start end study assessment joint range motion rom diet con provide blood samples diet con biomarker analysis including serum cartilage oligomeric matrix protein scomp marker cartilage degradation panel relevant biomarkers including pro anti inflammatory cytokines differences groups response aims components biomarkers except pro inflammatory cytokine alpha decreased diet group similar scomp decreased diet group similar significant improvement knee flexion hip rotation rom diet group average reduction scomp diet group represents meaningful change longer term effects require study
cockroach allergies caused american cockroach hyave recognized repsonsible ige mediated type hypersensitivity worldwide per one recognized main allergens american previous study examined another american allergen per patients allergies examined epitope sequences allergen present study aimed examine epitope sequences per allergen purpose per gene cloned expressed escherichia coli coli systems results revealed sera patients american allergies reacted per assessed elisa confirming per major allergen american results also revealed expression ccr passively sensitized basophils obtained sera patients american allergies increased approximately fold indicating recombinant per functionally active addition immunoinformatics tools namely dnastar protean system bioinformatics predicted antigenic peptides bpap system bepipred server used predict peptides results revealed peptides potential cell epitopes per allergen moreover per predicted cell epitope sequences namely findings study allergen may prove useful development peptide based vaccine prevention treatment allergies
extremely low frequency magnetic fields elf mfs exposure still topic concern due possible impact children health although epidemiological studies claimed evidence possible association elf childhood leukemia biological mechanisms able support causal relationship elf disease found yet provide knowledge children elf exposure correlated children daily activities measurement study conducted milan italy eighty six children recruited specifically chosen respect distance power lines built transformers oversample potentially highly exposed children personal bedroom measurements performed child two different seasons major outcomes study median values personal bedroom measurements established italian law quality target geometric mean values bedroom measurements mostly seasonal variations significantly influence personal bedroom measurements highest average levels mostly found home day outdoors significant differences found median geometric mean values personal bedroom measurements found arithmetic mean
vein marshall ablation introductionthe ligament marshall may hinder creation mitral isthmus block pulmonary vein isolation pvi radiofrequency catheter ablation atrial fibrillation aimed assess benefit ablation targeting vein marshall vom failed cases block pvi methods resultswe reviewed medical records patients underwent ablation targeting vom failed ablation left pvi using conventional method included circumferential point point ablation around antrum carina pvi endocardial epicardial distal coronary sinus ablation block vom identified using selective vom venography external irrigation ablation catheter ablation targeting vom performed application ostium vom inside endocardial region facing vom course set period venography performed patients failure left pvi block venography vom visualized patients pvi selective venography vom procedure related complication observed application targeting vom successfully achieved block patients pvi patients conclusionselective vom venography using irrigated ablation catheter feasible safe ablation targeting vom may provide additional benefit failed cases block pvi
intermolecular cross linking bone collagen intimately related way collagen molecules arranged fibril imparts certain mechanical properties fibril may involved initiation mineralization raman microspectroscopy allows analysis minimally processed bone blocks provides simultaneous information mineral organic matrix mainly type collagen components spatial resolution similar aim present study validate raman spectroscopic parameters describing one major mineralizing type trivalent cross links namely pyridinoline pyd achieve series collagen cross linked peptides known pyd content determined hplc analysis human bone porcine skin predentin dentin animal model tissues analyzed raman microspectroscopy results present study confirm feasible monitor pyd trivalent collagen cross links raman spectroscopic analysis mineralized tissues exclusively raman band similar wavenumbers allows determination relative pyd content undecalcified bone tissues spatial resolution similar thus enabling correlations histologic histomorphometric parameters
ambulatory pre screening point care poc device compatible commercially available diapers developed rapidly screen urine samples incontinent functionally impaired elderly poc device consists set colorimetric reaction pads accompanying reference colors smartphone camera convenient tool analysis colorimetric assays software application developed smartphones photograph colorimetric assay classify colorimetric reactions according reference colors facilitate detection multiple biomarkers biomarkers references per biomarker automatic localization test reference pads implemented recognition corner alignment marks projective coordinate transformation perspective removal test run trains set classifiers extracted reference data used classify extracted test data smartphone application gives semi quantitative results functions independently illumination intensity illumination color device type smartphone brand model device settings iso shutter speed aperture automatic camera preprocessing smartphone application tested successfully samsung galaxy edge edge zte nubia mini iphone various illumination conditions
important production practice discussed professional cultivation characteristics metallic materials engineering major harbin university science technology hrbust principal questions existed production practice stated means analysis research current situation production practice including large number student unwilling accept student enterprises practice ability low teachers metallic materials engineering example improvement measures proposed follows elaborating management production practice cooperation school enterprise improvement engineering practice ability teachers measures carried obtained pleased effects important referential significance production practice professional cultivation technological universities similar majors
flow field high order scheme usually calculated solve complex flow problems describe flow structure accurately however two problems reduced order boundary inevitable order scheme discontinuous shock wave contained flow field supersonic flow field low questionable whether reduced order boundary low order scheme shock wave effect numerical solution accuracy flow field inside paper according actual situation direct numerical simulation flow field two model equations exact solutions solved steady unsteady respectively study question high order scheme interior domain reduced order method boundary center domain comparing exact solutions found effect reduced order exists ignored addition two model equations exact solutions often used fluid mechanics also studied process reduced order problem
altemans risk factor cardiac arrhythmia including atrial fibrillation cellular level alternans observed beat beat alternations contraction action potential morphology magnitude transient cat widely accepted directional interplay membrane voltage crucial development alternans however recently attention shifted instabilities cellular handling role alternation remains poorly understood study provides new insights beat beat alternation morphology affects occurrence cat alternans atrial myocytes pacing induced cat alternans studied rabbit atrial myocytes using combined imaging electrophysiological measurements determine role morphology generation cat alternans trains two voltage commands form aps recorded large small alternans cats applied voltage clamped cells aps longer duration observed small amplitude alternans cat especially beat beat alternations morphology alternans reduced pacing frequency threshold increased degree cat alternans morphology contributes development cat alternans two mechanisms first waveform observed small alternans cats coincided higher end diastolic sarcoplasmic reticulum levels alternans resulted beat beat alternations end diastolic second type current significantly affected morphology wave form observed large cat elicited type currents higher magnitude faster kinetics resulting efficient triggering release conclusion alternation morphology plays significant role development stabilization atrial alternans demonstration cat alternans controlled even prevented modulating morphology important ramifications arrhythmia prevention therapy strategies elsevier ltd rights reserved
purpose purpose paper explore innovation adoption theory define model investigate operational activities communication innovation networks stimulate supply demand also aims exemplify model activities innovation network dedicated promoting passive houses design methodology approach autoethnography literature research used develop model order conduct structured analysis operational activities facilitate innovation decision processes using networks data activities used steer client decisions businesses innovation gathered network archives results social research methods applied within passive house network findings findings reveal operational activities multiplayer networks focus reinforcing conditions communicative activities support innovation decision processes one step next order activate supply demand communication strategies modelled increase adoption innovation continued knowledge generation networks research limitations implications one network evaluated housing sector exemplified may possible generalise research results researchers therefore encouraged test proposed model practical implications paper includes implications developing activities innovation networks order guide businesses customers steps adoption decision process social implications paper provides insights regarding uptake innovation construction sector beyond demonstration projects originality value paper connects innovation adoption activities network field construction
none proposed mechanisms alzheimer disease fully explains distribution patterns neuropathological changes cellular regional levels clinical correlates one aspect problem lies complex genetic epigenetic environmental landscape early onset often familial autosomal dominant inheritance vast majority cases late onset epsilon variant gene encoding apolipoprotein apoe known confer fold increased risk partial penetrance mechanisms genetic variants environmental factors influence development pathological changes especially neurofibrillary degeneration yet known review current knowledge involvement monoaminergic systems changes serotonergic noradrenergic dopaminergic histaminergic melatonergic systems briefly described also summarize possibilities monoamine based treatment besides neuropathologic criteria include noradrenergic locus coeruleus special emphasis given serotonergic dorsal raphe nucleus drn brainstem nuclei among first affected tau protein abnormalities course sporadic causing behavioral cognitive symptoms variable severity possibility tangle bearing neurons drn may release amyloid beta well soluble monomeric oligomeric tau protein trans synaptically diffuse projections cerebral cortex emphasizes selective vulnerability warrants investigations monoaminergic systems elsevier ltd rights reserved
paper aims synthesise literature attachment children autism spectrum disorder asd highlighting gaps current research applications clinical practice research databases psycinfo ovid medline cochrane library searched terms autism attachment forty papers investigating attachment children asd identified narratively reviewed seven samples identified reported attachment classifications using strange situation paradigm average children asd classified secure research date concluding children asd form secure attachments studies looking risk protective factors development attachment correlates attachment attachment disorders children asd attachment based interventions children asd many studies preliminary investigations contradictory findings reported highlighting important directions future research crown copyright published elsevier ltd rights reserved
objective despite great number substances produced skincare industry seem truly effect skin therefore given social implications surrounding physical appearance search new bioactive compounds prevent attenuate skin ageing enhance self image priority current research context rich valuable compounds proteins phenolics lipids vitamins study focused potential activity rapeseed press cake hydrolysates used raw materials skincare applications methods study protein rich press residue rapeseed oil industry converted enzymatically short chain biologically active peptides using four protease products varying substrate specificity alcalase protex protamex corolase antioxidant anti wrinkle anti inflammatory activities obtained hydrolysates evaluated invitro biocompatibility human skin fibroblasts tested results hydrolysates biocompatible skin fibroblasts exposure non hydrolysed extract induced cell toxicity alcalase protex obtained hydrolysates promising extracts showing improved bioactivities suitable skin anti ageing formulations namely antioxidant activity inhibiting approximately cellular reactive oxidative species anti inflammatory anti wrinkle properties inhibiting around myeloperoxidase activity elastase activity conclusion enzymatic technology applied rapeseed oil industry costream results release bioactive compounds suitable skincare applications
objective although emergency department visits offer opportunity deliver brief behavioral interventions improve health provision based interventions targeting adolescent sexual health uncommon objectives study evaluate feasibility preliminary effects novel sexual health service intervention adolescents methods cross sectional feasibility study sexually active patients aged years presenting midwestern pediatric recruited receive intervention improve sexual health intervention based motivational interviewing included agenda setting exploration behaviors decisional balance exercise tailored feedback provision personalized health services including condoms prescription emergency contraception urine testing chlamydia trachomatis neisseria gonorrheae referral hospital affiliated adolescent clinic data collected intervention administration month follow telephone interview surveys assessed sexual risk behaviors satisfaction intervention health care use demographics feasibility criteria subject rated interventionist fidelity principles likert scale strongly agree strongly disagree subject satisfaction likert scale session duration minutes recorded interventionist secondary outcome proportion subjects completed least health service services provided adolescent clinic determined electronic medical record review comparisons responses sex subgroups analyzed using test results august november adolescents approached completed screening survey reported previous sexual activity agreed participate mean age years female reported interventionist maintained high fidelity principles satisfied intervention mean intervention length minutes subjects accepted health services including completed clinic follow referral clinic following services provided subjects condoms emergency contraception prescription trachomatis gonorrheae testing hormonal birth control provision human immunodeficiency virus testing fifteen subjects reached month follow condom use maintained reporting sexual activity conclusions study demonstrated feasibility potential utility based service navigation intervention connect youth point care services well resources ongoing sexual health needs
determining optimal forest management provide multiple goods services also referred ecosystem services ess requires operational scale information suitability forest provisioning various ess remote sensing allows wall wall assessments provides pixel data flexible composition management units purpose study incorporate models provisioning potential spatial prioritization framework assess pixel level allocation land use tessellated forested area landscape altogether pixels modeled potential pixel provide biodiversity timber carbon storage recreational amenities indicators supporting provisioning regulating cultural ess respectively analyzed spatial overlaps individual ess potential provide multiple ess tradeoffs due production constraints fraction landscape pixels considered important individual ess overlapped much carbon storage timber production ess potential multiple ess could largely explained terms forest structure emphasized sparsely populated spruce dominated old forests large average tree size constraining production ess landscape based priority maps however resulted sub optimal choices compared optimized production even though land use planning completed without involving stakeholders preferences conclude workflow described paper produced valuable information overlaps tradeoffs ess related decision support elsevier rights reserved
sports injuries could highly detrimental career physical education teacher education pete student enable development future sports injury prevention programs sports injuries first year academic bachelor pete students registered prospectively one academic year common risk factors sports injuries taken literature also evaluated means logistic regression analysis found incidence rate injury risk higher generally found sports active population injuries involved lower extremities acute newly occurring injuries took place non contact situations half injuries lead inactivity period week injuries required medical attention major part injuries happened intracurricular sports classes differences seen women men history injury significant risk factor occurrence injuries performance cooling exercises significantly related lower occurrence ankle injuries data inform future programs prevention sports injuries pete students
attack intention recognition reason judge goal attackers according attack behavior network environment order deal dynamical character offense defense confrontation dynamical real time network attack intention recognition algorithm proposed correlating real time security alerts vulnerabilities recognized spread route stage attacks based graph theory probability theory identified attack intention predicted possible transition attacks combined network connectivity relationship simulation experiments proposed network attack intention recognition algorithm performed network examples experimental results show proposed method accurately identify attack intention fully predict post stage attacks
powder coatings receiving attention environmentally friendly contain solvents composition components decorative corrosion protection functions among many others however presence polymers composition increases risk combustion adverse situations context study aims develop characterize acrylic based powder paints addition montmorillonite clays mmt cloisite mmt cloisite mtt employed flame retardants characterization coatings carried thermogravimetric analysis tga ray diffraction scanning electron microscopy application coatings carbon steel substrates flammability tests performed coatings mmt showed overall better results especially flammability tests flames spread less coatings systems however surface bottom temperatures analyzed cone calorimeter test samples prepared mmt considered safer applied fire scenarios wiley periodicals inc appl polym sci
strategy games traditionally applied teaching subjects related decisions making principally university studies related company nevertheless potential methodology makes also applicable studies lead applicable practices companies factories like happens technical educations present paper shows methodology applied teaching engineering plant inside official master manufacturing engineering university cadiz circumscribing context material forming machine shop chip removal experience distributions process product simulated determining fictitious domain pass one another preceded determination finally discussion driven emphasize importance reduction dead times due movements
examine time period generational differences attitudes toward women work family roles two large nationally representative samples monitoring future survey graders general social survey adults twelfth graders became accepting working mothers equal roles women workplace change occurring late acceptance dual income families fathers working half time stay home dads also increased thus part millennials born continued trends toward egalitarian gender roles however slightly graders late favored husband achiever decision maker family adults attitudes toward working mothers became egalitarian early showed small backlash late continued trend toward increased egalitarianism hierarchical linear modeling analyses separating effects time period generation cohort age trends primarily due time period generational peak egalitarianism among white women boomers born policy makers recognize support working mothers solid majority position united states design programs working families accordingly
study classification apples oranges warehouse undertaken three qubit system using method repeated iterations grover algorithm ventura algorithm separately operator describing inversion average constructed square matrix order eight phase inversion operators corresponding iteration operators patterns separately representing apples oranges derived various possible superpositions choice search states classification patterns obtained starting states consisting two patterns single pattern respectively demonstrated second iteration exclusion superposition corresponding iteration operators patterns apples oranges respectively suitably classified using grover algorithm probabilities classifications apples also calculated using ventura algorithm ventura martinez inf sci found phys lett possible superpositions search states results compared grover algorithm demonstrated general classification given pattern apples three qubit system grover ven tura algorithms effective cases number patterns stored database larger smaller respectively
dynamic models needed automatic control online fault detection diagnosis desiccant wheels used solar cooling systems parameters models need experimentally identified operation model based heat mass transfer equations given state space representation developed using model gray box approach developed identify experimentally thermal transfer coefficients nusselt number heat mass transfer coefficients obtained defining unknown parameters model function single parameter depends heat transfer coefficient expressing parameters function geometrical physical properties wheel difference values thermal transfer coefficients given literature obtained method less therefore gray box identification method may adopted tool experimental estimation thermal coefficients various design operation conditions desiccant wheels elsevier rights reserved
article focuses design investigation pair unequally sized wireless electricity witricity devices equipped integrated planar coil strips proposed pair devices consists two different square shaped resonator sizes acting transmitter receiver respectively devices designed simulated optimized using cst microwave studio software prior fabricated verified using vector network analyzer vna surface current results coupled devices indicate good current density distance range good current density demonstrates coupled devices surface electric current per unit area leads good performance range hence results also reveal good coupling efficiency coupled devices approximately distance devices axially aligned addition coupling efficiency achieved maximum lateral misalignment varied angular misalignment degrees degrees implemented proposed device
education parenting became increasingly child centred progressive post war england article contends impact shift concepts childhood children equivocal progressive methods physically emotionally demanding teachers parents popularised versions developmental psychology psychoanalysis shaped limiting concept child article also suggests line recent work thomson shapira changing concepts childhood map democratic selfhood capabilities children lacked must possessed adult citizen exploring children defined relation adults adults needs increasingly subordinated child article also begins question might usefully use age category historical analysis
remote sensing applications water resources management becoming essential asset different levels integrated water rational use due remote sensing data availability different acquisition sensors satellite images wide variability benchmarks could conducted theme rainwater harvesting branch science rainwater main target improve groundwater recharge stratocumulus clouds main source rain arid regions cloud detection using remote sensing techniques proved efficient recently general uses different cloud detection techniques precisely omit clouds satellite images use cloud detection scheme described herein designed meris levelb data therefore total set meris images collected monthly basis years started january use cloud detection algorithm find proper land cover suitable rainwater harvesting mostly covered cloud year evaluation land use rainwater harvesting terms groundwater recharge considered several factors taken consideration ndwi one important factors involved results pointed regions southern saudi arabia qualified enough considered potential sites better rainwater harvesting
paper present novel kernel adaptive recurrent filtering algorithm based autoregressive moving average arma model trained recurrent stochastic gradient descent reproducing kernel hilbert spaces kernelized recurrent system kernel adaptive arma kaarma algorithm brings together theories adaptive signal processing recurrent neural networks rnns extending current theory kernel adaptive filtering kaf using representer theorem include feedback compared classical feedforward kaf methods kaarma algorithm provides general nonlinear solutions complex dynamical systems state space representation deferred teacher signal propagating forward hidden states demonstrate capabilities provide exact solutions compact structures solving set benchmark nondeterministic polynomial complete problems involving grammatical inference simulation results show kaarma algorithm outperforms equivalent input space recurrent architectures using first second order rnns demonstrating potential effective learning solution identification synthesis deterministic finite automata
combining high strength hardness high toughness remains tremendous challenge materials engineering interestingly nature overcomes limitation materials bone display unusual combinations properties spite weak constituents materials highly mineralized building blocks provide stiffness strength weak interfaces blocks channel non linear deformation trigger powerful toughening mechanisms strategy also exploited multilayered ceramics fiber reinforced composites recently topologically interlocked materials work apply concepts toughening glass panels incorporating internal architectures carved within material using three dimensional laser engraving glass relatively stiff hard microstructure inelastic deformation mechanism low toughness poor resistance impacts demonstrate introducing controlled architectures glass completely changes material deforms fails particular new architectured glass panels resist two four times impact energy plain glass architectured glass also displays nonlinear deformation progressive damage failure contained within building blocks work demonstrates micro architecture bio inspiration top fabrication strategies provide new pathways transform mechanics performance materials structures elsevier ltd rights reserved
biomarkers may key foundation precision medicine future article review current knowledge regarding biomarkers difficult treat asthma ability guide use conventional asthma therapies novel targeted therapies biomarkers measured tests including prednisolone cortisol assays fractional exhaled nitric oxide suppression test show promise assessment management nonadherence inhaled oral corticosteroids multiple markers type inflammation developed including eosinophils sputum blood exhaled serum ige periostin although show potential guiding selection novel interventions refractory type inflammation asthma determining desired response achieved becoming clear different biomarkers reflect distinct components complex type inflammatory pathways less progress made identifying biomarkers use difficult treat asthma associated type inflammation future likely see biomarker discovery direct measurements individual cytokines rather surrogates activity increasing use biomarkers combination promise biomarkers fulfilled need provide useful information aids clinical decision making rather another test clinicians order
integrated design process encourages integration team members design phase green building projects intense collaborative processes free exchange information although integration general particular well theorized construction management research community exists systematic mechanism field help owners architects managers green project teams assess level integration projects team environment practical manner key objective present article therefore use qualitative quantitative methodology propose validate integration evaluation framework green project teams statistically test association integration level project success framework used green project teams comparison benchmarking educational purposes integration evaluation improvement team environments research also provides empirical evidence anecdotes suggesting positive link team integration project success green projects
aims hypoalbuminemia common heart failure especially elderly patients associated increased risk death present study sought examine prognostic significance serum albumin level prediction hospital mortality patients admitted acute non ischemic methods results examined association albumin hospital mortality cohort patients admitted acute non ischemic none patients infectious disease severe arrhythmias atrial fibrillation ventricular tachycardia ventricular fibrillation required invasive ventilation presented acute coronary syndrome primary valvular disease thirty six patients died hospital stay patients significantly older years higher heart rate increased creatinine level lower systolic diastolic blood pressures elevated leucocyte count lower albumin levels multivariable analysis age heart rate diastolic blood pressure leukocyte count serum albumin level emerged independent predictors hospital mortality hypoalbuminemia yielded best sensitivity specificity predicting hospital death conclusions serum albumin level measured admission serve simple prognostic factor acute non ischemic hypoalbuminemia associated increased risk hospital mortality especially elderly patients
recent advances technologies high density array based genotyping dna rna deep sequencing expression quantitative trait loci mapping epigenome analyses new computational strategies introduced drastic shifts understanding major histocompatibility complex mhc association immune mediated diseases review exciting findings field show fine characterization structural features expression levels ofmhcalleles posttranslational environmental modifications hla bound peptides epistatic interactions non hla genes made possible provide mechanistic explanations mhc associations immune mediated diseases also help choose relevant therapeutic targets
amiodarone antiarrhythmic agent commonly used treat supraventricular ventricular arrhythmias iodine containing compound associated several adverse events like tends accumulate several organs among serious amiodarone pulmonary toxicity apt incidence complication decreased use lower doses amiodarone occur dose pulmonary complications usually present acute subacute pneumonitis chest ray high resolution computed tomography diffuse infiltrates found present case acute respiratory distress syndrome like features detected got subsided stopping tablet amiodarone patient known case atrial fibrillation taking tablet amiodarone last six months
background health education impact questionnaire heiq evaluates effectiveness health education self management programs provided people dealing wide range conditions aim study translate culturally adapt validate dutch translation heiq compare results english german french translations methods systematic translation process undertaken psychometric properties studied among patients arthritis atopic dermatitis food allergy asthma factorial validity using confirmatory factor analysis item difficulty item remainder correlation composite reliability conducted stability tested using intra class correlation coefficient icc results items well understood minor language adjustments required confirmatory fit indices item difficulty items scales showing acceptable fit indices except reversed emotional distress scale composite reliability ranged test retest reliability icc varied comparisons translations showed comparable fit indices lower icc self monitoring insight scale observed conclusions dutch translation heiq found well understood user friendly patients rheumatoid arthritis atopic dermatitis food allergy asthma robust psychometric properties evaluating impact health education self management programs given wide applications heiq comparability dutch results english german french version heiq practical useful questionnaire evaluate impact self management support programs different countries populations different diseases
mechanized forestry much work conducted use cranes recovering potential energy possible method reduce energy consumption using cranes lift work objective study evaluate capacity new energy efficient hydraulic lift cylinder ehlc secondary cylinder built piston rod store potential energy lowering boom form pressurized hydraulic oil accumulator using stored energy next boom lift ehlc mounted forwarder manipulated enable use also standard cylinder compared ehlc standard cylinder terms function energy consumption repetitive boom lifts lowerings tested settings ehlc saved approximately energy consumed first part boom lifts total lift energy possible adjustments optimization accumulator size enlargement assisting cylinder diameter enhancement accumulator pressurization importantly reduction internal leakage current ehlc could commercial potential
fishes display wide variation physiological responses stress clearly evident plasma corticosteroid changes chiefly cortisol levels fish well known indicator fish stress simple rapid method detecting cortisol changes especially sudden increases desired study describe enzyme functionalized label free immunosensor system detecting fish cortisol levels detection cortisol using amperometry achieved immobilizing anti cortisol antibody selective detection cortisol glucose oxidase signal amplification non toxic measurement electrode surface self assembled monolayer system based maximum glucose oxidation output current change induced generation non conductive antigen antibody complex depends levels cortisol sample immunosensor responded cortisol levels linear decrease current range since dynamic range sensor cover normal range plasma cortisol fish samples obtained fish need diluted electrochemical measurement one sample required similar min sensor system applied determine cortisol levels plasma sampled nile tilapia oreochromis niloticus compared levels samples determined using conventional method elisa values determined using methods well correlated findings suggest proposed label free immunosensor could useful rapid convenient analysis cortisol levels fish without sample dilution also believe proposed system could integrated miniaturized potentiostat point care cortisol detection useful portable diagnostic fish farms future
exposure winter triticale cold promotes genotype dependent resistance fungal pathogen present evidence structural chemical modifications cell wall components induced cold correlated resistance fungal infection results showed cellulose hardened triticale hewo able develop resistance cold treatment compact integrated structure thicker longer fibres compared magnat susceptible fungal infection despite plant hardening structure cellulose limits water sorption favours stronger bonding water crystallisation macromolecules impedes depolymerisation process decomposition finally results higher thermal stability cell wall furthermore lignin composition drastically modified resistant plants pattern thermal decomposition indicates higher molecular mass complex structure lignin followed higher thermal stability conclude specific structure lignocellulosic cell wall resistant plants forms barrier fungal enzymes digesting host tissue well resist better mechanical pressure hyphae
background acute exacerbation idiopathic pulmonary fibrosis ipf high short term mortality unknown causes predict malignant condition clinics challenging study aim demonstrate whether mirnas differ ipf stable ipf may served reliable biomarker ipf prediction methods human fibrotic associated mirnas arrays designed detect mirnas expression plasma aeipf patients stable ipf ipf patients normal controls differentially expressed mirnas ipf ipf patients selected analyses validation studies carried plasma ipf patients ipf patients healthy control subjects signaling pathways cellular processes interacted validated mirnas predicted diana mirpath results according array analysis mirnas showed differentiated expression ipf ipf patients validation studies let decreased ipf decreased ipf compared mir obviously decreased ipf significantly increased receiver operator characteristic roc curve analysis areas curve aucs mir let respectively sensitivity fixed specificity improved two mirnas combined functional prediction mirnas suggested loss anti fibrotic capacity gain uncontrolled cell growth may required ipf pathogenesis conclusions conclusion mir let plasma differentially expressed ipf ipf combination two mirnas may potential biomarker ipf ipf
melatonin hormone synthesized pineal gland regulates number physiological processes mammals range clinical applications synthetic analogue hormone humans animals increasing paper based observations describes applicability tablets various cases abnormal behavior cats dogs cases efficacy confirmed include among others animal anxiety caused excessive noise left alone home transportation disturbances drug applied include excessive excitability cats dogs postoperative period resulting breaking stitches licking fresh surgical wounds well various types stereotypies animal chasing tail dermatitis caused obsessive licking aggression towards animals owner additional argument favor applying cats dogs virtual non toxicity
backgroundpatients frequently report antibiotic allergies however labelled patients true allergy aimwe investigated documentation antibiotic allergy labels aal effect labelling clinical outcomes west australian adult tertiary hospital methodsretrospective cross sectional analysis patients captured national antimicrobial prescribing surveys carried data collected documented antibiotic adverse drug reactions antibiotic cost prescribing appropriateness prevalence multi drug resistant organisms length stay intensive care admission readmissions resultsof patients surveyed aged male prescribed antibiotics aal recorded patients majority penicillin labels details aal documented individual allergy labels describing allergic symptoms patients beta lactam allergy labels received fewer penicillins aminoglycosides metronidazole patients without beta lactam labels five patients received antibiotic contraindicated according allergy status patients aal significantly hospital readmissions within weeks months discharge compared unlabelled patients majority readmitted labelled patients major infections conclusions aal common poorly documented hospital records patients aal significantly likely require alternative antibiotics hospital readmissions may role antibiotic allergy delabelling mitigate clinical economic burdens patients invalid allergy labels
research typically reveals outgroups regarded disinterest best hatred enmity worst working evolutionary framework identify unique pattern outgroup attraction small group lifestyle pre human ancestors plausibly limited access genetically diverse mates ancestral females may solved inbreeding dilemma balancing parental investment pressures mating outgroup males either via converting outgroup cuckolding ingroup vestige mating strategies might manifest human women cyclic pattern attraction across menstrual cycle attraction outgroup men increases fertility increases across cycle two studies one using longitudinal method experimental method evidenced hypothesized linear relationship attraction outgroup men fertility naturally cycling women
multidrug toxin extrusion mate transporter family comprises members medicago truncatula genome play seemingly important yet mostly uncharacterized physiological functions employed bioinformatics molecular genetics identify characterize mate transporters involved citric acid export tolerance translocation mtmate citric acid transporter induced deficiency overexpression mtmate hairy roots altered homeostasis hormone levels deficient oversupplied conditions mtmate plasma membrane citric acid transporter primarily expressed root epidermal cells mtmate mutant less root growth wild type stress seedlings chlorotic deficient conditions overexpression mtmate rendered hairy roots tolerant toxicity mtmate involved seedling development iron homeostasis well hormone signaling mtmate mutant delayed development chlorotic leaves mature plants knock overexpression mutants mtmate showed altered accumulation abnormal hormone levels compared wild type demonstrate zinc finger transcription factor mtstop essentially required mtmate expression plant resistance toxicity proper expression two previously characterized mate flavonoid transporters mtmate mtmate also depends several transcription factors study reveals functional diversity mate transporters regulatory mechanisms legumes stresses also casts light role metal nutrition hormone signaling various stresses significance statement many mate transporters legumes potentially diversified functions analyzed mutants overexpression lines two mate transporters involved citric acid export aluminum tolerance iron translocation one mate transporter affecting growth development iron homeostasis manipulating expression mate transporters might prove useful improving tolerance acidic soils aluminum stress
problem controlling doubly fed induction generators dfig associated wind turbines addressed control objective twofold maximum power point tracking reactive power regulation dfig unlike previous works seek achievement control objective without resorting physical sensors mechanical variables wind turbine velocity dfig rotor speed interestingly wind velocity also assumed accessible measurements control problem dealt using output feedback controller designed basis nonlinear state space representation controlled system controller constituted high gain nonlinear state observer nonlinear sliding state feedback mode using tools lyapunov stability formally shown closed loop control system expressed terms state estimation errors output reference tracking errors enjoys semi global practical stability accordingly possible tune controller design parameters meets objectives arbitrarily high accuracy whatever initial conditions theoretical results confirmed simulations involving wide range variation wind speed
construction site layout planning complex important task conducted project managers planners must able face occurrence potential hazards like fire blast waves instance however minimizing risk resulting natural technological hazards still scientific challenge present paper new methodology developed order evaluate risks within construction site consists modeling construction site components instance electric generator fuel storage offices equipment material storages layout components act hazardous sources potential targets time modeling hazard interaction matrix shows hazard interaction among site components attenuation hazard distance modeling vulnerability interaction matrix represents potential weakness whole targets hazard generated source present research vulnerability expressed function hazard intensity defining utility function aims afford optimized site layout minimum total risk construction site finally performing spatial analysis technique utilizing space syntax principle realize space configurations construction site evacuation process considered evaluating visualizing risk actual risk amplified utilizing penalty factor called mean depth geographic information system gis useful visualizing spatial variability risk within site integrates potential total impact facilities space configuration mean depth results illustration purposes methodology employed case study consisting several facilities acting hazardous sources potential targets layout risk optimization considers level hazards source object hazard attenuation adopts conditional values vulnerability target objects differential evolution algorithm adopted minimize global risk within site results showed proposed methodology efficient due capability generating site layout safer work environment turn leads minimize work accidents serious injuries victims addition model capable highlighting highest risk areas within construction site elsevier rights reserved
currently serious investigations made road security critical research domain however majority based expensive infrastructure paper propose new scheme warnings spreading vehicles without dependence road foundation new concept active vehicle combines power intelligence ambient technologies introduced alert endorsement suggest new model trust management vanet based cooperation active vehicles order enhance security states cut spread false warnings vehicular network authors published elsevier
presentation trainer multimodal tool designed support practice public speaking skills giving user real time feedback different aspects nonverbal communication tracks user voice body interpret current performance based performance presentation trainer selects type intervention presented feedback user feedback mechanism designed taking consideration results previous studies show difficult learners perceive correctly interpret real time feedback practicing speeches paper present user experience evaluation participants used presentation trainer practice elevator pitch showing feedback provided presentation trainer significant influence learning
introduction proteasome inhibitors treatment multiple myeloma patients therapeutic success peripheral neuropathy pnp remains one frequent side effects experienced patients receive novel agents recent investigations mechanisms pnp patients treated bortezomib suggested genetic susceptibility neurotoxicity used data genome wide association study conducted bortezomib treated german patients replicate previously reported associations single nucleotide polymorphisms snps candidate genes pnp patients including snps nominal significance value twelve associations confirmed significance level value corresponding snps located genes involved drug metabolism abcc abcc development function nervous system pogz nfat pathway edn modulation immune responses ilrd ilra signaling pathway psmb btcr systematically investigated functional consequences variants using several bioinformatics tools haploregv regulomedb ucsc genome browser expression quantitative trait loci eqtl data suggested identified snps might influence gene expression differential recruitment transcription factors conclusion confirmed recently reported associations germline variation pnp elucidating mechanisms underlying associations contribute development new strategies prevention reduction pnp
background undesirable outcomes health care associated patient harm substantial excess costs coarctation aorta coa one common congenital heart diseases repaired stenting requires monitoring subsequent interventions detect treat disease recurrence aortic wall injuries avoidable costs associated stenting patients coa unknown methods developed economic model calculate potentially avoidable costs stenting treatment coa united kingdom years calculated baseline costs intervention potentially avoidable complications follow interventions compared costs hypothetical scenarios improved treatment effectiveness complication rates results baseline costs pound per patient avoidable costs ranged pound per patient scenario assuming reduction aortic wall injuries reinterventions follow pound best case scenario treatment success complications overall costs best case scenario overall costs baseline reintervention rate follow identified influential lever overall costs probabilistic sensitivity analysis showed considerable degree uncertainty avoidable costs widely overlapping confidence intervals conclusions significant improvements treatment effectiveness reductions complication rates required realize discernible cost savings total baseline costs could avoided best case scenario highlights need pursue patient specific treatment approaches promise optimal outcomes
adenosine triphosphate involved many metabolic reactions also role cellular danger signal transmitted purinergic receptors prs indeed adenosine triphosphate atp bind prs found membrane many cell types although relative proportions receptor subtypes differ prs classified according genetic pharmacological criteria especially affinities agonists transduction mechanism metabotropic pyrs ionotropic pxrs extracellular atp release activated necrotic cells may activate various prs especially pxr best characterized immune cells pxr known regulate activation nod like receptor nlr family protein nlrp inflammasome permit release potent pro inflammatory cytokine pxr nlrp pathway involved many inflammatory diseases gout fibrosis diseases associated inflammatory process liver lung fibrosis authors imaging also real promising therapeutic potential pxr blockage thus several pharmaceutical companies developed pxr antagonists novel anti inflammatory drug candidates clinical trials efficacy antagonists underway better understanding pxr nlrp signalling pathways permits identification targets development new class drugs able inhibit fibrogenesis process collagen deposition
reducing discolouration events aging water supply networks major challenge facing water utilities worldwide required comply increasingly stringent water quality regulations proactive cost effective manner emerging control methods dynamic reconfiguration network topologies could reduce risk discolouration regulating hydrodynamic conditions facilitate implementation self cleaning networks review paper provides holistic assessment mechanisms pathways govern discolouration processes associated models impact system hydraulics control rules formulated possible role biofilms conditioning wall bound cohesive layers identified methods effective removal discussed information presented identifies key variables research gaps facilitate development near real time hydraulic network topology control long term proactive management discolouration risk
paper proposes automatic generation control agc interconnected multi area multi source hydrothermal power system deregulated environment two equal control areas hydro thermal generating power sources interconnected via parallel links optimal proportional integral regulators designed proposed power system simulate power market transactions possible restructured power system concept disco participation matrix dpm harnessed simulate transactions eigenvalue study conducted assess effect parallel links system performance study also conducted considering appropriate generation rate constraints grcs thermal hydro generating sources dynamic responses proposed multi source hydrothermal power system compared single source thermal thermal power system ascertained responses proposed power system sluggish large overshoots settling times finally study extended frame implement optimal regulators first time agc conventional two area non reheat thermal power system governor dead band nonlinearity superiority optimal regulators established comparing results recently published best claimed craziness based particle swarm optimization crazypso hybrid bacterial foraging optimization algorithm particle swarm optimization hbfoa pso algorithms based controller tuned interconnected power system elsevier ltd rights reserved
whether total joint replacement tjr patients susceptible postoperative cognitive dysfunction pocd remains unclear due inconsistencies research methodologies moreover cognitive reserve may moderate development pocd tjr investigated context current study investigated pocd tjr relationship cognitive reserve using rigorous methodology previously utilized fifty three older adults aged scheduled tjr assessed pre post surgery months forty five healthy controls matched age gender premorbid assessed equivalent interval cognition cognitive reserve physical mental health measured standardized regression based methods used assess cognitive changes controlling confounding effect repeated cognitive testing tjr patients demonstrated significant decline trail making test part tmt performance compared controls cognitive reserve predicted change tmt scores among subset tjr patients specifically patients showed improvement pre post surgery significantly higher reserve showed greatest decline current study provides limited evidence pocd tjr examined using rigorous methodology controlled practice effects cognitive reserve predicted performance within subset tjr sample however role reserve cognitively compromised patients remains determined
violence digital games source controversy scientific community general public two decades research examined issue however much research undercut methodological limitations ideological statements beyond scientific evidence could support review years experimental cross sectional longitudinal meta analytical research field empirical evidence regarding impact violent digital games player aggression best mixed support unambiguous claims games harmful represent public health crisis rather indulgence claims risked damage credibility games effects research credibility restored better empirical research conservative careful statements scholars encourage field engage responsible dialog constructive debate could continue enriching invigorating
aimsto explore clinical features methamphetamine induced paranoia mip associations mip genetic polymorphism dopamine hydroxylase dbh designretrospective analysis clinical presentation genetic association test logistic regression analysis settinga thai substance abuse treatment center participantsa total methamphetamine dependent individuals measurementsclinical semi structured assessment drug dependence alcoholism ssadda methamphetamine experience questionnaire meq genetic dbh findingsforty per cent individuals mip within binge latency mip onset occurred rapidly recent compared initial mip episode despite unchanging intake individuals mip significantly less likely carry lower compared higher activity genotypes versus dbh effects confirmed odds ratio controlling associated clinical variables severity antisocial personality disorder alcohol dependence nicotine dependence carriers likely initiate cigarette smoking probably less likely dependent alcohol conclusionsamong methamphetamine dependent individuals paranoia appears occur increasingly rapidly course session methamphetamine use severity methamphetamine dependence antisocial personality disorder predicts methamphetamine induced paranoia genetic polymorphism dopamine hydroxylase associated methamphetamine induced paranoia influences smoking initiation
background preparation ablation temporary withdrawal thyroid hormone commonly used patients thyroid cancer total thyroidectomy current study aimed investigate brain glucose metabolism relationships mood cognitive function patients using fluoro deoxyglucose positron emission tomography fdg pet method total consecutive adult patients thyroid carcinoma undergone total thyroidectomy recruited cross sectional study time assessment patients hypothyroid two weeks thyroid hormone withdrawal received thyroid hormone replacement therapy euthyroid participants underwent brain fdg pet scans completed mood questionnaires cognitive tests multivariate spatial covariance analysis univariate voxel wise analysis applied image data results hypothyroid patients anxious depressed euthyroid participants multivariate covariance analysis showed increases glucose metabolism primarily bilateral insula surrounding areas concomitant decreases parieto occipital regions hypothyroid group level thyrotropin positively associated individual expression covariance pattern decreased fdg uptake right cuneus cluster univariate analysis correlated increased thyrotropin level greater depressive symptoms hypothyroid group conclusions results suggest temporary hypothyroidism even short period may induce impairment glucose metabolism related affective symptoms
recent years large amounts fire accidents happened countryside due problems electric circuits adversely affect rural people daily lives becomes increasingly important solve problems rural electrical fire southwest rural area china fire situation severe fire accidents occur frequently chosen surveyed situation rural electric circuits strength fire rescue southwest countryside china investigated fire fatalness wood houses potential perils electrical fire rural area presented finally suggestions electrical fire prevention rural area put forward published elsevier ltd
propose incorporate encryption procedure lossy compression voice data pcm pulse code modulation based law approximation quantization proposed codec cpcm chaotic pulse code modulaion join encryption compression voice data scheme provides compression ratio given pcm codec unintelligible content comparisons many used schemes made highlight proposed method terms security rapidity cpcm codec better alternative compress encrypt classical methods time resource consuming non suitable real time multimedia secure transmission
study investigated direct indirect effects biological psychological sociocultural factors predicting disordered eating behaviors girls overweight obesity total hispanic african american girls bar age years completed surveys assessing desire thinner peer weight related teasing disordered eating behaviors demographic characteristics percent body fat assessed structural equation modeling conducted examine influence desire thinner peer weight related teasing percent body fat disordered eating behaviors results indicated percent body fat directly related desire thinner peer weight related teasing indirectly related disordered eating relationship peer teasing findings may useful guiding design interventions preventing development disordered eating behaviors minority girls
well known computer widely used almost fields paper hirota bilinear method computer symbolic computation extended new akns hierarchy variable coefficients result one soliton solutions two soliton solutions obtained analysis obtained one soliton solutions two soliton solutions uniform formulae soliton solutions derived shown computer running obtained one soliton solutions two soliton solutions satisfy akns hierarchy
achieve squarewave output direct digital synthesizer dds without analog signal processing lower order bits dds accumulator used properly position rising falling edges accumulator significant bit msb digital technique called time filtering proposed individually manipulate rising falling edge accumulator msb technique shown achieve design goals design parameters necessary meet spurious suppression requirements presented
although median survival polycythemia vera years mortality higher age sex matched population study included patients diagnosed surveillance epidemiology end results seer registry determine year survival incidence second primary malignancies spm actuarial year survival overall cohort cumulative incidence spm years spms occurred standardized incidence ratio sir absolute excess risk aer per population significantly higher risk noted acute myeloid leukemia sir value chronic myeloid leukemia sir value patients high risk spm leukemic transformation may compromise long term survival
paper solution limit problems important subject high school university mathematics presented using javacc code generation tool symbolic computation methods although javacc generally used generating programming language interpreters similar way also used evaluation mathematical expressions work first general grammar rules limit expressions extracted parser code limit expressions generated javacc according grammar rules using list tokens limit expression parsed code abstract syntax tree ast constructed finally solution obtained interpreting ast class visitor design pattern study regarded promising contribution computer assisted education
well established low level visual features affect person categorization bottom fashion studies examined top influences however largely focused information recalled memory motivation influences categorization investigated race categorizations affected context targets perceived manipulating semantic information associated faces categorized found presenting faces systematically varied racial ambiguity race congruent incongruent semantic labels shifted threshold perceivers distinguished racial groups semantic information offered labels therefore appeared influence categorization race findings suggest semantic information creates context interpretation perceptual cues social categorization highlighting active role top information race perception
intentional unintentional leakage confidential data undoubtedly one severe security threats organizations face digital era threat extends personal lives plethora personal information available social networks smartphone providers indirectly transferred untrustworthy third party fourth party applications work present generic data lineage framework lime data flow across multiple entities take two characteristic principal roles owner consumer define exact security guarantees required data lineage mechanism toward identification guilty entity identify simplifying non repudiation honesty assumptions develop analyze novel accountable data transfer protocol two entities within malicious environment building upon oblivious transfer robust watermarking signature primitives finally perform experimental evaluation demonstrate practicality protocol apply framework important data leakage scenarios data outsourcing social networks general consider lime lineage framework data transfer key step towards achieving accountability design
fear negative evaluation fne state anxiety dominance consequences social functioning present study assessed fne target dominance relevant label related perceptions personality one hundred seventy eight participants scored high low fne underwent laboratory manipulation viewed photograph target high low dominance relevant label rated target big five personality traits dominance fne unrelated perceptions high dominance label associated perceptions higher dominance conscientiousness openness conclusion judges use information others making initial judgments personality judgments impacted trait state psychological distress
paper presents new electronically tunable voltage mode universal biquadratic filter one input five outputs employing five operational transconductance amplifiers two grounded capacitors one resistor filter offer voltage mode low pass band pass high pass band stop pass filter responses circuit properties circuit inverting type input signal requirements high input impedance orthogonal electronic control natural frequency quality factor also possessed moreover active passive sensitivities filter low pspice simulation results provided demonstrate theoretical analysis
animals inhabit mid high latitude regions exhibit various adaptive behaviors migration reproduction molting hibernation response seasonal cues adaptive behaviors tightly regulated seasonal changes photoperiod relative day length night length recently regulatory pathway seasonal reproduction elucidated using quail birds deep brain photoreceptors receive transmit light information pars tuberalis pituitary gland induces secretion thyroid stimulating hormone thyroid stimulating hormone locally activates thyroid hormone via induction type deiodinase mediobasal hypothalamus thyroid hormone induces morphological changes terminals neurons express gonadotropin releasing hormone facilitates gonadotropin secretion pituitary gland mammals light information received photoreceptors retina neurally transmitted pineal gland inhibits synthesis secretion melatonin crucial seasonal reproduction importantly signaling pathway downstream light detection signaling fully conserved mammals birds fish regulatory components seasonal reproduction integrated light detection neuroendocrine output fish specific organ called saccus vasculosus various physiological processes humans also influenced seasonal environmental changes findings discussed herein may provide clues addressing human diseases seasonal affective disorder
irritable bowel syndrome like symptoms response wheat ingestion common well described whether reaction due gluten non coeliac gluten sensitivity wheat proteins fodmaps mostly fructans alone combinations clearly defined exclusion coeliac disease presence negative serology normal villous architecture increased density intraepithelial lymphocytes duodenal biopsies difficult furthermore confidence positive diagnosis made non coeliac gluten sensitivity excluded blinded placebo controlled rechallenge wheat protein reduced strong nocebo responses generally found patients self reported non coeliac gluten sensitivity absence clear biological mechanism action difficulties design interpretation research studies plunged entity even deeper controversy absence clarity diagnosis epidemiology prognosis therapeutic approaches patient may gluten sensitive remain determined adequate understanding issues surrounding controversy research slowly unravel truth behind problem
increase contribution renewable energy sources grid part smart grid initiatives integration renewables solar energy electrical network challenge grid operators intermittency due weather variations despite installed capacity solar globally continues increase thus forecasting becoming important tool system grid operators manage solar photovoltaic energy production satisfy demand energy consumers work aims develop forecasting model solar irradiance used calculating next day energy generation solar systems site specific solar irradiance meteorological parameters used inputs machine learning algorithm shown prediction model fits measured data value equal model validated measured data power generation hybrid connected solar system installed quezon city philippines authors published elsevier open access article license http creativecommons org licenses
study objective examine relationship sleep dietary intake adolescents using experimental sleep restriction protocol design randomized crossover sleep restriction extension paradigm setting sleep obtained monitored home diet measured office visit participants forty one typically developing adolescents age years interventions week protocol consisting baseline week designed stabilize circadian rhythm followed randomly consecutive nights sleep restriction hours bed monday friday versus healthy sleep duration hours bed night washout period night crossover period measurements sleep monitored via actigraphy teens completed validated hour diet recall interviews following experimental condition results paired sample tests examined differences conditions consumption key macronutrients choices dietary categories compared healthy sleep condition sleep restricted adolescents diets characterized higher glycemic index glycemic load trend toward calories carbohydrates differences fat protein consumption exploratory analyses revealed consumption significantly desserts sweets sleep restriction healthy sleep conclusions chronic sleep restriction adolescence appears cause increased consumption foods high glycemic index particularly desserts sweets chronic sleep restriction common adolescence may cause changes dietary behaviors increase risk obesity associated morbidity
restoration mandibular bone defects cancer facilitated computer assisted preoperative planning aim study assess house manufacturing approach customized cutting guides use reconstruction mandible osteocutaneous free flaps retrospective cohort study performed involving patients underwent mandibular reconstruction fibula free flap three institutions period july march single surgeon designed manufactured fibula mandible cutting guides using computer aided design process three dimensional printing technology oncological outcomes production parameters quality reconstructions performed patient recorded computed tomography scans acquired surgery compared preoperative models eighteen consecutive patients squamous cell carcinoma underwent surgery reconstruction using customized house surgical approach lengths fibula bone segments angle measurements simulations similar postoperative volume rendering ease access printing technology enabled computer aided design manufacturing customized cutting guides oral cancer treatment without need input external laboratories
high intensity resistance exercise rex training increases physical capacity part improving muscle cell size function moderate intensity rex feasible many older adults disease disability also increases physical function mechanisms underlying improvements understood therefore measured skeletal muscle structure function molecular tissue level response moderate intensity rex physically inactive older adults knee osteoarthritis although rex training increased quadriceps muscle cross sectional area csa average single fiber csa unchanged reciprocal changes myosin heavy chain mhc iia fibers intermyofibrillar mitochondrial content increased training increases mitochondrial size men women changes subsarcolemmal mitochondria either sex rex increased whole muscle contractile performance similarly men women contrast adaptations single muscle fiber force production per csa tension contractile velocity varied men women fiber type dependent manner adaptations explained molecular level differential changes myosin actin cross bridge kinetics mechanics single fiber mhc protein expression results notable compared studies high intensity rex show effects moderate intensity rex older adults muscle fiber size structure myofilament function absent modest moreover data highlight unique sex specific adaptations due differential cellular subcellular structural functional changes new noteworthy moderate intensity resistance training causes sex specific adaptations skeletal muscle structure function cellular molecular levels inactive older adult men women knee osteoarthritis however responses minimal compared high intensity resistance training thus adjuncts moderate intensity training need developed correct underlying cellular molecular structural functional deficits root impaired physical function mobility limited population
generalized prejudice biases expressed toward multiple outgroups typically explained two aspects authoritarianism bowing form submission right wing authoritarianism rwa kicking form dominance social dominance orientation sdo whereas contemporary approaches treat rwa sdo separate predictors statistically model commonality rwa sdo reflecting underlying tendency toward generalized authoritarian analyzing data existing meta analysis study modelling meta analytic data studies containing clear relevant information study compare standard approach predicting based rwa sdo unique predictors model alternative approach based latent factor indicated rwa sdo model alternative model provided stronger near perfect prediction along specific associations rwa two types prejudice sexism homophobia findings fundamental implications understanding authoritarianism prejudice proneness elsevier ltd rights reserved
secure communication protocols becoming increasingly important internet based communication quantum key distribution qkd allows two parties commonly called alice bob generate secret sequence called key known classically alice bob could never certain communication compromised malicious eavesdropper quantum mechanics however makes secure communication possible fundamental principle quantum mechanics taking measurement perturbs system unless measurement compatible quantum state also applies eavesdropper using appropriate protocols create key alice bob detect presence eavesdropper errors measurements part quvis quantum mechanics visualisation project developed suite four interactive simulations demonstrate basic principles three different qkd protocols simulations use either polarised photons spin particles physical realisations simulations accompanying activities freely available use online download run wide range devices including tablets pcs evaluation students three years used refine simulations activities preliminary studies show refined simulations activities help students learn basic principles qkd introductory advanced undergraduate levels
performance fourier transform based fundamental current detection algorithms evaluated compared paper difficult conditions imposed load draws highly distorted current slight fluctuation non equal semi periods implemented algorithms recursive discrete fourier transform rdft discrete fourier transform dft implemented finite impulse response fir filter respectively fast fourier transform fft butterfly operation radix decimation time dit digital signal processor dsp based solution used real time implementation namely dspace controller development board matlab simulink software used design algorithms provides specialized tools blocks performance comparison one used criteria like total harmonic distortion thd settling time detected fundamental current also run time dsp study may useful guide engineers selecting suitable fourier transform based control algorithm active power filters grid synchronized equipments operating difficult load conditions
short chain fatty acids scfas play crucial role maintaining homeostasis humans therefore importance good reliable scfas analytical detection raised lot past years aim scoping review show trends development different methods scfas analysis feces based literature published last eleven years major indexing databases search criteria included analytical quantification techniques scfas different human clinical vivo studies scfas analysis still predominantly performed using gas chromatography followed high performance liquid chromatography hplc nuclear magnetic resonance nmr capillary electrophoresis performances drawbacks advantages methods discussed especially light choosing proper pretreatment feces complex biological material optimization develop simple cost effective robust method routine use needed elsevier inc rights reserved
aging process menopausal transition important factors sexual dysfunction menopausal women neuroimaging study assessed age menopause related changes brain activation areas associated sexual arousal menopausal women purpose study evaluate time course regional brain activity associated sexual arousal evoked visual stimulation premenopausal menopausal women assess effect menopause brain areas associated sexual arousal menopausal women using functional magnetic resonance imaging fmri thirty volunteers consisting premenopausal menopausal women underwent fmri activation condition volunteers viewed sexually arousing visual stimulation brain areas significantly higher activation premenopausal women compared menopausal women included thalamus amygdala anterior cingulate cortex acc using analysis covariance adjusting age blood oxygen level dependent signal changes amygdala viewing erotic video positively correlated estrogen levels two groups findings suggest reduced brain activity thalamus amygdala acc menopausal women may associated menopause related decrease sexual arousal findings might help elucidate neural mechanisms associated sexual dysfunction menopausal women ibro published elsevier ltd rights reserved
objective investigate relationship low testosterone levels prostate cancer detection risk biopsy population patients methods men underwent initial core transrectal prostate biopsy institution included retrospective study patients divided groups low clinical pathological data analysed results among men men low testosterone levels positive biopsy high grade prostate cancer mean age prostate specific antigen psa level psa density body mass index bmi number abnormal digital rectal examination dre findings diabetes mellitus history significantly different low normal level testosterone groups low testosterone level significantly associated higher risk detection overall prostate cancer normal testosterone level univariate analysis odds ratio multivariate analysis adjusting parameters age psa prostate volume bmi abnormal dre findings meanwhile low testosterone level significantly related higher rate high grade prostate cancer compared normal testosterone level univariate multivariate analysis adjusting parameters conclusion low testosterone level independent risk factor high grade prostate cancer detection biopsy therefore checking testosterone levels could help determine whether prostate biopsy carried
review examines detail bob reinhardt meticulous analyses smallpox eradication within broad context american liberalism cold war politics exercise technological medical political power part united states result book provides unique perspective eradication smallpox
maternal exposure environmental pollutants could affect fetal brain development increase autism spectrum disorder asd risk conjunction differential genetic susceptibility organohalogen congeners measured maternal midpregnancy blood samples recently shown significant negative associations offspring asd outcome report first large scale maternal fetal genetic study midpregnancy serum levels set organohalogens subset genotyped women children collected california early markers autism ema project levels pcb polychlorinated biphenyl pbde polybrominated diphenyl ether congeners showed high maternal fetal estimated snp based heritability accounting total variance genome wide association analyses identified significant maternal loci dde cypb gene bde near shgl gene involved xenobiotic lipid metabolism fetal genetic loci contributed levels bde pcb near potential metabolic genes loxhd ptprd previously implicated neurodevelopment negative associations observed bde bde sum pbdes asd partly explained genome wide additive genetic effects predicted pbde levels results support genetic control midgestational biomarkers environmental exposures nonoverlapping maternal fetal genetic determinants suggesting future studies environmental risk factors take genetic variation consideration independent influence fetal genetics supports previous hypotheses fetal genotypes expressed placenta influence maternal physiology transplacental transfer organohalogens
imagination sometimes leads people behave feel think though imagined events real even know paper suggest understanding phenomena achieved differentiating implicit truth value itv spontaneous truth evaluation explicit truth value etv self reported truth judgment three experiments measure itv using autobiographical implicit association test sartori agosta zogmaister ferrara castiello used assess two autobiographical events true findings demonstrate imagining event like experiencing event increases itv even people explicitly acknowledge imagined event false experiments furthermore show imagined representations generated first person perspective higher itv imagined representations generated third person perspective experiment findings suggest implicit explicit measures truth differ sensitivity properties underlying truth judgment discuss contribution characterizing events according itv etv understanding various psychological phenomena lying self deception elsevier rights reserved
large left hemisphere porencephalic cyst incidentally found year old woman diagnostic statistical manual dsm diagnosis schizophrenia encephaloclastic characteristics cyst indicated acquired gestational weeks major waves neuronal migration tapered cyst destroyed left temporal occipital lobes inferior parietal lobule surprisingly evidence aphasia alexia agraphia ideational apraxia contrast cognitive functions dependent integrity right hemisphere severely impaired test hypothesis development language took place expense functions normally carried right hemisphere investigated correlates oral comprehension fmri proxy auditory comprehension cognitive functions strongly lateralized posterior left hemisphere ideational praxis reading comprehension spoken language engaged homologous wernicke area right planum temporale porencephaly may represent natural model neuroplasticity supervening predictable epochs prenatal development
fungi cause billion skin infections million mucosal infections million serious allergies million deaths year global mortality owing fungal infections greater malaria breast cancer equivalent owing tuberculosis hiv statistics evidence fungal infections major threat human health major burden healthcare budgets worldwide patients greatest risk life threatening fungal infections include weakened immunity suffered trauma predisposing infections hiv address global threats human health research urgently needed understand immunopathology fungal disease human disease susceptibility order augment advances made fungal diagnostics drug development highlight recent advances basic research medical mycology fungal immunology beginning inform clinical decisions options personalized medicine vaccine development adjunct immunotherapies article part themed issue tackling emerging fungal threats animal health food security ecosystem resilience
introductionfractional exhaled nitric oxide feno used marker airway inflammation airway caliber related level feno asthmatics objectivesthis study aimed investigate whether airway obstruction could interfere real feno levels different feno changes albuterol inhalation could assist distinguishing asthma chronic obstructive pulmonary disease copd methodsfeno spirometry measurements performed albuterol inhalation following three patient groups steroid naive asthmatics asthmatics inhaling corticosteroids long acting adrenergic agonists least month copd patients bronchodilator test bdt results positive patients enrolled correlations among feno levels pulmonary function sputum eosinophil counts analyzed resultsfeno increased significantly albuterol inhalation steroid naive asthmatics ics treated asthmatics copd patients feno levels demonstrated significant correlation spirometry results sputum eosinophil counts inhaling bronchodilator three groups levels feno changes feno albuterol inhalation steroid naive asthma patients higher ics treated asthmatics copd patients differences remained proper adjustment confounding factors gender age smoking pack years ics treated pulmonary function index conclusionsour results support role feno differentiating asthmatics copd patients positive bdt feno detection albuterol inhalation encouraged steroid naive asthma patients airway obstruction
social cognition refers ability use social cues infer meaning intentions behind behaviour others order respond socially adaptive manner increasingly recognised disorders social cognition including problems emotion perception theory mind conversational inference morality judgements decision making social inhibition characterise many developmental psychiatric disorders highly relevant many acquired brain injuries diseases especially frontotemporal dementias review provides introduction overview papers special edition social cognition places context recent research several current issues clinical management social cognition delineated given social cognition seems sensitive predictor psychosocial function assessment social cognition seen many clinicians important although profession responsible yet resolved issues social cognition assessed discussed including importance context social cognition interactive nature need recognise influences family upbringing gender emotional state social cognitive performance also needs development tests address aspects social cognition including decision making inhibition finally review discusses intervention research interventions especially well developed relation schizophrenia less well developed brain injury appear generally effective although treatments emotional self awareness yet developed
computer mouse tracking relatively recently developed behavioral methodology contribute unique insight wide variety psychological phenomena recording mouse movements route specific responses screen researchers glean continuous information tentative commitments multiple response alternatives time approach yields richness data fully explored variety sophisticated analytic techniques approaches relatively underutilized difficult adopt describe several techniques researchers examine onset timing evolving decision processes test degree response competition different time points assess trajectory complexity spatial disorder analyses identify qualitatively distinct psychological processes response generation finally distill unique meaningful components mouse tracking data subsequent analysis guide hope researchers address novel hypotheses otherwise inaccessible traditional methods
study investigates another calendar anomaly literature yet address week year woy effect using weekly returns stock market indexes countries worldwide period ends december findings demonstrate returns week starts october ends november positive countries also statistically significant contrast returns week starts october ends october negative countries statistically significant countries also apply investment strategy derived findings prediction period find strategy beats simple buy hold policy substantial margin elsevier rights reserved
objective objectives study describe mri findings pedal phalangeal bone marrow edema patients raynaud phenomenon discuss clinical implications mri findings conclusion progressive distal proximal pattern pedal phalangeal bone marrow edema mri patients knowledge may allow early diagnosis treatment rheumatologic disorders potentially associated
background trauma commonly associated substance related problems yet associations specific substances specific posttraumatic stress disorder symptoms ptsss understudied hypothesized substance related problems associated ptss severities interpersonal traumas benzodiazepine prescriptions methods using cross sectional survey methodology consecutive sample adult outpatients trauma histories used logistic regression examine substance related problems general primary confirmatory analysis well alcohol tobacco illicit drug problems specifically secondary exploratory analyses relation demographics trauma type ptsss benzodiazepine prescriptions results adjusting multiple testing several factors significantly associated substance related problems particularly benzodiazepines aor alcohol tobacco illicit drugs dsm ptsd diagnosis aor alcohol tobacco illicit drugs ptsss especially negative beliefs recklessness avoidance interpersonal traumas assaults child abuse conclusion clinical sample consistent strong associations several trauma related variables substance related problems consistent hypotheses discuss possible explanations implications findings hope stimulate research improve screening treatment
objectives atrioventricular nodal ablation avna recommended patients pts cardiac resynchronization therapy crt atrial fibrillation incomplete ventricular capture class iia level avna reduces mortality improves new york heart association nyha functional class intermediate term follow objectives study long term outcome regarding quality life qol survival crt pts avna design crt pts undergoing avna due inadequate biventricular pacing included study data retrospectively obtained clinical records telephone interviews results twenty pts died follow period average months avna ventricular capture improved significantly significant sustained improvement average nyha functional class found additionally large percentage pts discontinued taking rate reducing drugs potential severe side effects conclusion avna crt pts safe effective treatment resulted sustained improvement qol including long term improvement nyha functional class
new generator control unit gcu must designed work wide frequency range order obtain better control performance variable frequency power system control algorithms make improvements terms determining control parameters analyze influence controller parameters system stability compensate loss signals generated conditioning process paper compares pros cons different rms algorithms determine final rms calculation scheme test results show considerable performance improvement proposed design dynamic performance adjustment precision
adaptive algorithms prevalently applied design nonlinear active noise control anc systems important nonlinearity anc saturation effect produced electro acoustical sensors transducers dominant saturation nonlinearity transducers represented wiener model effective solution mitigate nonlinear distortion employ nonlinear filtered least mean square nlfxlms algorithm controller compensates nonlinearity using model saturation effect represented scaled error function sef however nlfxlms limited two practical issues degree nonlinearity known advance sef evaluated real time work nlfxlms algorithm modified incorporating tangential hyperbolic function thf model saturation effect loudspeaker proposed thf nlfxlms algorithm models nonlinear secondary path applies estimated degree nonlinearity control algorithm design results show wiener secondary path saturation nonlinearity represented sef modelled thf certain degree accuracy yield reasonable estimate degree nonlinearity performance proposed algorithm comparable benchmark nlfxlms superior conventional fxlms well second order volterra algorithm similar computational complexity proposed algorithm
many tiller crops plant architecture including plant fresh weight plant height number tillers tiller angle stem diameter significantly affects grain yield study propose method based volumetric reconstruction high throughput three dimensional wheat studies proposed methodology involves plant volumetric reconstruction multiple images plant model processing phenotypic parameter estimation analysis study performed triticum aestivum plants results analyzed comparing automated measurements manual measurements mean absolute percentage error mape plant height plant fresh weight average plant height average plant fresh weight respectively root mean square error rmse plant height plant fresh weight respectively correlation coefficients plant height plant fresh weight respectively additionally proposed methodology including plant reconstruction model processing trait extraction required approximately average per plant using parallel computing graphics processing unit gpu demonstrating methodology would valuable high throughput phenotyping platform
aims study analyze relationship food insecurity adherence antiretroviral therapy art among people hiv evaluate contribution four possible mediators lack time due work family responsibilities lack resources satisfy needs psychological distress side effects art differences adherence according level cross sectional survey convenience sample people hiv attending two public institutions mexico city conducted variables assessed questionnaire logistic regression models estimated people moderate likely skip dose reported low adherence last month poor adherence among people explained side effects art unsatisfied needs lack time psychological distress may curtail benefits universal access policies associated lower adherence art adjustment health services reduce negative effects adherence art required
background unlike tablet tab formulation liquid liq directly absorbed intestine aim study assess whether liq superior tab would overcome interference induced ingestion multiple interfering drugs methods prospective cohort study recruited patients apparent reduced tab absorption due switched liq maintaining daily dose ingestion serum tsh assayed least twice every eight weeks results serum tsh significantly lower liq compared tab patients took either replacement tsh suppression difference evident already first measurement post switch regardless purpose therapy patients took two lower serum tsh liq compared patients took three interestingly patients failed reach target tsh levels liq took three conclusions liq overcomes concurrent interference exerted ingestion multiple cases switching tab liq permits patients reach target tsh within weeks
work present ultra low energy sensor image processing architecture based cellular network spin based neurons neuron constitutes lateral spin valve lsv multiple input magnets connected output magnet using metal channels low resistance magneto metallic neurons operate small terminal voltage similar performing analog computation upon photo sensor inputs static current flow across device terminals limited small periods corresponding magnet switching time determined low duty cycle systemclock thus energy cost analog mode processing inevitable image sensing applications reduced made comparable dynamic leakage power consumption peripheral cmos units performance proposed architecture common image sensing processing applications like feature extraction halftone compression digitization obtained physics based device simulation framework coupled spice results indicate proposed design scheme achieve two orders magnitude reduction computation energy compared state art cmos designs based conventional mixed signal image acquisition processing schemes knowledge first work application nano magnets analog signal processing proposed keywords
multi scale ordered patterns multi component polymer mixtures reveal many peculiar chemical physical properties makes systems important potential applications materials engineering via computer simulation create interesting ordered multi scale structures photosensitive immiscible polymer mixtures system employed comprises ternary molten polymer blends three components mutually immiscible polymer non optically active polymers exhibit reversible chemical reaction reversible arrow induced light firstly investigate phase behavior ternary blend guided cross stripy mask light find chessboard like ordered pattern forms mixture removing mask illuminated regions components gather ellipsoidal core shell structures uncrossed illuminated area components gather star structures crossed stripes regions remove mask entire system becomes illuminated reaction reversible arrow occurs throughout film ellipsoidal core shell structures components turn spherical structures star structures components turn concentric square ring structures show influences number cross stripes initial composition formation structure average spatial volume fraction component first increases decreases stripy number increasing component net lattices play important role stability ordered structures secondly blend covered annular mask component gathers illuminated regions components radial arrangement result mixture forms interesting dartboard like pattern however mask removed photochemical reactions occur components whole region increasing free energy induces dartboard like pattern broken change dots ring structure forms perfect concentric ring pattern target like pattern also show effects initial composition ratio component distance two adjacent rings ring width illumination intensity evolution ordered structure larger initial composition ratio component easily ordered target like pattern forms larger distance smaller width better pinning effect component illumination intensity little influence ordered morphology ternary system provide simple approach creating multi scale patterned films long range order could guide fabricating nanoscale devices
nodes wireless sensor network wsn mobile network highly dynamic monitoring every node times impractical result intruder attack network easily thus impairing system hence detecting anomalies network essential handling efficient safe communication overcome issues paper propose rule based anomaly detection technique using roaming honeypots initially honeypots deployed way nodes network covered least one honeypot honeypots check every new connection letting centralized administrator collect information regarding new connection slowing communication new node certain pre defined rules applied new node make decision regarding anomality node timer value honeypot expires sensor nodes appointed honeypots owing honeypot rotation intruder able track honeypot impair network simulation results show technique efficiently handle anomaly detection wsn
order improve aircraft efficiency reliability maintainability aerospace world found progressive electrification board services way reduce remove presence hydraulic mechanical bleed air pneumatic systems concept called electric aircraft mea involves introduction electromechanical actuators emas electro hydraulics actuators ehas actuation flight surfaces wide body aircraft moving fly wire power wire concept resulting step change aircraft electrical loading far reaching implications electrical generation system considerable effort directed towards realizing called electric engine mee foresee integration electrical generator directly inside main gas turbine engine also entire electrical distribution system subject radical revisiting trend leaving constant frequency energy distribution favor variable frequency solutions hence evident mea trend increments technical challenges research topics electrical engineering aeronautic applications aim paper presentation electrical engineering point view challenging application electric machines drives incoming new aircraft generation many board electric components systems analyzed authors centre attention safety critical drives flight surface actuators fuel pumps generators
magnesium isoglycyrrhizinate mgig extensively used treating liver injury common adverse reaction docetaxel doc due narrow therapeutic window small changes pharmacokinetic profiles alter toxicity therapeutic efficacy doc significantly study aimed explore effects mgig disposition doc potential mechanism doc induced liver injury pharmacokinetics tissues distribution behaviors showed significant difference doc group docg mgig doc group mdocg mrna protein levels cytochrome cypa liver intestine kidney significantly upregulated glycoprotein obviously downregulated mdocg compared docg immunoglobulin igm upregulated docg mdocg igm recovered normal levels complement upregulated mgig significant effects disposition doc docetaxel induced liver injury additional potential drug drug interaction may happen mgig administered antitumor drugs substrates cypa hepatoprotective mechanism mgig perhaps upregulation downregulation igm
alcohol smoking frequently occur alcohol primary trigger smoking behavior relapse back smoking study examined whether several indices alcohol use behavior consequences use would associated changes implicit alcohol approach versus implicit cigarette approach cognitions cigarette deprived non deprived cognitions smokers drank risky non risky levels implicit association task iat measured quickly respondents paired alcohol cigarette pictures approach avoid words regression analyses examined associations quantity frequency proportion heavy drinking days number dsm alcohol use disorder aud symptoms risky drinking status iat scores deprived conditions controlling iat order effects non deprived iat score deprived cigarette craving withdrawal interactions craving withdrawal intensity also examined results showed significant positive association proportion heavy drinking days stronger alcohol approach cigarette approach motivations deprived also conditional association aud symptoms alcohol approach motivations among respondents reporting intense withdrawal deprived alcohol quantity frequency well risky drinking status unrelated change iat scores findings suggest cigarette deprivation may magnify motivation drink rather smoke among smokers engage frequent bouts heavy drinking report alcohol related problems results also show relative momentary unconscious preference choice alcoholover cigarettes high risk smokers cigarette craving withdrawal high elsevier ltd rights reserved
paper presents focus error propagation aspect exists interconnected networks handling issues considerations implied negative property method ensuring fault tolerance reliability real time routing processes developed specifying phenomenon effects prevented real time transmissions need constant flow require priority data packets sent conditions provided contribution article consist algorithmic synchronization method impact network errors attenuated method concentrated algorithm design use time interval based tuning parameters specifies algorithm actions synchronize routing devices perform rerouting data interconnected environments
paper focused sustainable development advanced manufacturing technology discussed information technology new materials technology biotechnology enormous supporting advanced manufacturing technology important roles pointed information technology soul advanced manufacturing technology many advanced manufacturing modes based information technology new material technology key development advanced manufacturing technology basis actual application advanced manufacturing technology biotechnology provided new manufacturing models methods advanced manufacturing technology advanced manufacturing technology made encouraging progress result bio manufacturing engineering kind advanced manufacturing mode bionic design kind advanced design method based biotechnology
next generation sequencing combined bioinformatics powerful tool analyzing large number dna sequences present expressed antibody repertoire data sets used advance number research areas including antibody discovery engineering accurate measurement immune repertoire sequence composition diversity abundance important understanding repertoire response infections vaccinations cancer immunology could also useful elucidating novel molecular targets study individual domestic cats felis catus subjected antibody repertoire sequencing total number sequences generated igg igm analysis suggests similar vdj expression patterns exists across cats similar canine repertoire feline repertoire dominated single subgroup namely antibody paratope felines showed similar amino acid variation compared human mouse canine counterparts animals show similarly skewed cdr profile compared canine human mouse distinct differences observed study represents first attempt characterize sequence diversity expressed feline antibody repertoire demonstrates utility using ngs elucidate entire antibody repertoires individual animals data provide significant insight understanding feline immune system function international alliance biological standardization published elsevier ltd rights reserved
loop handover lho technique proposed overcome problem close loop performance digitally controlled single inductor multiple output boost converters start presented technique utilises existing clock source requires small number blocks also occupies smaller silicon area thus consuming low power increasing efficiency presented technique validated proposed chip digital controller multiple output boost converter architecture using segmented delay line digital pulse width modulation experimental results show successful close loop reduced transients using simpler lho technique
ozonation representative taste odor compound isobutyl methoxy pyrazine ibmp drinking water systematically investigated study batch experiments conducted evaluate influencing factors including initial ibmp concentration addition rate initial dosage different water qualities degradation ibmp ozonation process results showed degradation ibmp followed pseudo first order kinetics degradation rate constants increased increasing addition rate initial value whereas decreased increasing initial ibmp concentration degradation ibmp mainly dominated direct ozone oxidation low free radical oxidation may become dominant high levels moreover appropriate dosage greatly increase ibmp degradation rates large excess would act center dot scavenger inhibit degradation addition lower degradation rate observed raw water compared deionized water overall ozonation promising treatment technology control ibmp associated water pollution
sure wireless sensor networks wsns becoming ultimate part next generation mobile networks master piece ubiquitous computing indeed sustain development numerous paradigms technologies distributed ambient intelligence context awareness future mobile networking battery life remains one crucial problems handle article propose infrastructure based topology using mobile ferries mobile micro base stations real life ferry could robot bus tram train engine scrutinizing periodically given area yet message ferries moving along concentric annulus may collect data generated static sensors could classic sensors smart meters wearable devices etc randomly distributed given area next transmissions performed ferry ferry forwarding scheme till arriving sink considered ferries could sense data therefore behave mobile sensors allowing better awareness area state scheme could also assist machine machine communications increase network lifetime potentially cognitive radio capabilities opportunistic detection access proposal easily integrated smart city better interaction green communications next present queueing model queues finite capacity handle generated traffic analyze behavior mobile ferries provided close form expression end end throughput end end delay main objective work improve energy efficiency cognitive sensors asking cognitive sensors care forwarding data except urgent data latter point scope paper static sensors care data sensing reduce individual energy consumption elsevier rights reserved
introduction aim study systematically review growing body published literature reporting one specific multiple sclerosis treatment fingolimod real world assess effectiveness patients evaluate methodologies used investigate clinical practice describe evidence gaps exemplified fingolimod methods conducted prisma compliant systematic review literature cut date march published papers reporting real world data fingolimod regard clinical outcomes persistence adherence healthcare costs healthcare resource use treatment patterns patient reported outcomes met eligibility criteria included data extraction quality assessment results discussion based included studies analysis found fingolimod treatment improved outcomes compared period treatment initiation effective interferons glatiramer acetate however among studies comparing fingolimod natalizumab overall trends inconsistent reported natalizumab effective fingolimod others reported similar effectiveness natalizumab fingolimod studies illustrate challenges investigating real world including subjectivity evaluating clinical outcomes heterogeneity methodologies used patient populations investigated limit comparisons across studies gaps available real world evidence also highlighted including relating patient reported outcomes combined clinical outcomes measure overall treatment effectiveness healthcare costs resource use conclusions included studies provide good evidence real world effectiveness fingolimod highlight diversity methodologies used assess treatment benefit clinical practice future studies could address evidence gaps found literature challenges associated researching designing real world studies assessing data comparing evidence across studies author published elsevier open access article license http creativecommons org licenses
autophagy highly conserved pathway mediates bulk degradation cellular components lysosomes vacuoles plays important role filamentous fungi impacting growth morphology development however leaf rust role autophagy poorly understood study identified structure autophagy leaf rust infection structures using transmission electron microscopy tem results suggest autophagy strongly induced haustorium mother cell hmc occur special infection structures appressorium substomatal vesicle haustorial applying autophagy inhibitor mehyladenine leaf rust resulted significant arrest mycelial growth delays leaf rust infection results suggest autophagy induced hmc important fungal infection wheat research help expand understanding physiological functions autophagy filamentous fungi
background emerging paradigm holds resistance development allergic diseases including allergic rhinoconjunctivitis relates intact epithelial epidermal barrier early childhood conceivably immunologic genomic footprint resistance preserved nonatopic nonallergic adults unmasked exposure aeroallergen objective aim study obtain direct support epithelial epidermal barrier model allergic rhinoconjunctivitis methods twenty three adults allergic house dust mites hdms nonsensitive nonallergic participants completed hour exposures aerosolized hdm dermatophagoides pteronyssinus powder consecutive days allergen challenge chamber analyzed peripheral blood leukocyte levels immune responses rna sequencing derived expression profiles nasal cells hdm exposure results hdm challenge onlym persons developed allergic rhinoconjunctivitis symptoms peripheral blood leukocyte levels responses gene expression patterns nasal cells largely concordant participants gross differences parameters observed baseline pre exposure two key differences observed first peripheral blood cell activation levels initially decreased participants versus increased participants second compared participants genes promoted epidermal epithelial barrier function filament aggregating protein filaggrin versus inflammation chemokines innate immunity interferon upregulated versus muted respectively conclusion imprint resistance hdm challenge nonatopic nonallergic adults muted cell activation peripheral blood inflammatory response nasal compartment coupled upregulation genes promote epidermal epithelial cell barrier function
present study examined role target judge interaction demands first impression accuracy specifically role targets self presentation concerns judges information processing demands accuracy interpersonal traits traits likely accentuated within interpersonal context less interpersonal traits traits less likely accentuated within interpersonal context examined pairs unacquainted participants females males interacted ten minutes one three interaction conditions sought vary interaction demands manipulating degree participants aware judging judged accuracy assessed correlating judgements formed measure target personality comprised average self ratings informant ratings findings revealed interaction conditions mismatch evaluation expectations participant knows judge judged accuracy less interpersonal traits diminished findings discussed relation patterson parallel process model interpersonal communication funder realistic accuracy model limitations terms generalisability findings discussed elsevier ltd rights reserved
early responses stimuli measured sensory evoked potentials using repeated identical stimuli response may represent efficient stimulus detection suppression response may represent inhibition early responses stimuli may related impulsivity compared reflecting stimulus detection inhibition bipolar disorder healthy controls investigated relationships impulsivity subjects healthy controls without family histories mood disorder bipolar disorder measured latencies amplitudes auditory pre attentional initial direction attention initial conscious awareness using paired click paradigm identical stimuli apart impulsivity measured questionnaire laboratory tests inability suppress responses stimuli delay response reward analyses used general linear models amplitudes gating lower bipolar disorder controls amplitude correlated accurate laboratory task responding amplitude correlated impulsive task performance fast reaction times bipolar disorder correlate impulsivity findings independent symptoms treatment substance use history eps related questionnaire measured reward based impulsivity bipolar disorder characterized reduced pre attentional early attentional stimulus registration relative controls within bipolar disorder rapid response impulsivity correlates impaired pre attentional response suppression results imply specific relationships erp measured response inhibition rapid response impulsivity elsevier ltd rights reserved
challenge studying human cognitive evolution identifying unique features intelligence explaining processes arose comparisons nonhuman apes point early emerging cooperative communicative abilities crucial evolution forms human cultural cognition including language human self domestication hypothesis proposes early emerging social skills evolved natural selection favored increased group prosociality aggression late human evolution product selection humans predicted show traits domestication syndrome observed domestic animals reviewing comparative developmental neurobiological paleoanthropological research compelling evidence emerges predicted relationship unique human mentalizing abilities tolerance domestication syndrome humans synthesis includes review first priori test self domestication hypothesis well predictions future tests
argument make straightforward one constant news media coverage excessive lifestyles consumption patterns called super rich normalize extreme privilege obfuscating privilege many others examine series typical news stories print broadcast together examples popular books show mediatization super rich ambivalently organized mixture celebratory derisive stances tandem logics capital tenets consumer culture lurid spectacles fuel complex mix anxiety desire among target readers viewers absolving responsibility relatively seemingly modest excesses invited also defend grounds superior judgement taste
homeostatic conditions well various diseases leukocyte migration crucial issue immune system mainly organized activation bone marrow derived cells various tissues immune cell trafficking orchestrated family small proteins called chemokines leukocytes express cell surface receptors bind chemokines trigger transendothelial migration allergic diseases asthma rhinitis food allergies atopic dermatitis generally classified tissue rather type inflammation making chemokine chemokine receptor system key point immune response moreover small antagonists easily block receptors various molecules developed suppress recruitment immune cells allergic reactions representing potential new drugs allergies review chemokines chemokine receptors important asthma food allergies atopic dermatitis respectively developed antagonists
aims work first evaluate nutritional requirements early weaned kits days age especially fibre experiment protein experiment needs experiment early weaned rabbits offered days age one three experimental diets containing increasing acid detergent fibre level fibre substituted starch fat obtain three isoenergetic diets experiment early weaned rabbits offered days age one three experimental diets containing increasing crude protein level protein substituted starch fat obtain three isoenergetic diets studies revealed effect dietary fibre level dietary level health status days age rabbits given diets containing fibre level level showed lowest growth rate compared respective treatments secondly research aimed evaluate interaction age weaning days days age food diets digestive health performances young rabbits experiment diet formulated contain per starch fibre according nutritional requirements diet formulated reach starch fibre according results experiments litters nine pups per litter assigned days age one four experimental groups factorial design rabbits rabbits rabbits rabbits food intake live weight influenced feeding strategy days age mortality higher group center dot center dot respectively center dot period growth rate proportionately center dot higher conventionally weaned early weaned rabbits center dot days age food intake growth rate proportionately center dot center dot higher respectively conventionally early weaned rabbits center dot consequently live weight higher conventionally weaned rabbits days age proportionately center dot center dot respectively center dot mortality rate days points higher center dot early weaned conventionally weaned pups points higher center dot days age data suggest removal milk feeding early weaning leads detrimental effects health growth young compensated diet meeting better nutritional needs
interest tau protein fast increasing alzheimer disease diagnosis urgent need highly sensitive specific diagnostic platforms quantification also combination hallmarks spr poorly exploited tau detection immunosensing due sensitivity limits nanomolar level whereas clinical requirement picomolar range molecular architectures built layer layer fashion biomolecules nanostructures metallic may amplify spr signal improve limit detection desired sensitivity mostly gold nanostructures widely employed aim great interest also emerging multi walled carbon nanotubes mwcnts mwcnts modified decorated secondary antibody tau protein eventually took advantage mwcnts antibody conjugate obtain sandwich based bioassay capability increase spr signal folds compared direct detection conventional unconjugated sandwich respect results hope give strong impulse investigation studying possible roles carbon nanotubes optical based biosensing
psoriasis chronic systemic immune mediated inflammatory dermatosis associated several comorbidities psoriasis patients increased risk developing cardiovascular diseases cvd namely coronary heart disease stroke peripheral vascular disease psoriasis seems independent cardiovascular risk factor antipsoriatic systemic therapy especially anti tumor necrosis factor tnf seems exert beneficial effect comorbidities purpose study measure level cardiovascular serum markers psoriasis patients comparison healthy volunteers compare serum level markers patients months adalimumab therapy investigated six biomarkers connected cvd reactive protein measured high sensitively hscrp oxidized low density lipoproteins oxldl oxldl glycoprotein complex oxldl gpi vascular endothelial adhesion molecule vcam selectin interleukin biomarkers measured patients moderate severe psoriasis treatment adalimumab healthy volunteers hscrp oxldl gpi complex selectin significantly increased comparison healthy controls whereas oxldl vcam also higher psoriasis patients difference reach statistical significance decrease selectin observed months adalimumab therapy inhibition tnf seems improve psoriasis also decreases serum cardiovascular biomarkers selectin could serve monitoring efficacy antipsoriatic systemic therapy cardiovascular risk
power systems generating masses data including measurement simulation data operate control power systems effectively paper establishes distributed platform store read compute massive amounts data distributed computing platform support online simulation based power system security knowledge discovery big data analysis first framework distributed computing platform designed distributed algorithms developed including distributed massive sampling simulation method distributed feature selection method next software platform hardware platform distributed computing platform established finally platform applied guangdong province power system china evaluate accuracy efficiency simulation results show distributed computing platform improve computing efficiency perform better centralized platform
flexible business processes often modelled easily using declarative rather procedural modelling approach process mining aims automating discovery business process models existing declarative process mining approaches either suffer performance issues real life event logs limit expressiveness specific set constaint types lately relationalxes relational database architecture storing event log data introduced paper introduce mining approach directly works relational event data querying log conventional sql leveraging database performance technology mining procedure fast without limiting detecting certain control flow constraints queries customised cover process perspectives beyond control flow organisational aspects evaluated performance capabilities approach regard several real life event logs
paper presents integrated error propagation analysis method estimate measurement uncertainty using monte carlo method order analyze measurement accuracy drive stage air bearing high acceleration subjected influence variety errors including straightness errors thermal errors deformation errors air bearing gap change errors caused acceleration force firstly integrated error propagation model drive stage built combined effects various error sources based multi body system instrument precision theory errors identified experiments finite element analysis influence error six degrees freedom displacement obtained finally displacement measurement uncertainty stage reference coordinate system evaluated monte carlo method within probability displacement measurement results expanded uncertainty directions calculated respectively proposed method used error budget precise machine design applied error compensation improve measurement control accuracy precise machine workpiece stage elsevier ltd rights reserved
mathematics filling draining permeable geotextile bag developed previous investigation large geotextile containers used dewater dredged material mine tailings resulting outflow draining bag looks remarkably like overland flow hydrograph analog model overland flow developed draining bag compared experimental runoff data obtained laboratory number rolled erosion control blankets analog model defined dimensionless parameter includes permittivity term characterizes rate runoff comparison analog model measured runoff excellent across entire range natural geosynthetic erosion control products investigated
simulated spectrometric observations unresolved resident space objects required interpretation quantities measured optical telescopes allows characterization part regular space surveillance activity peer reviewed spacecraft reflectance model necessary help improve understanding characterization measurements objective mind novel approach model spacecraft spectral reflectance overall spectral bidirectional reflectance distribution function sbrdf presented spacecraft overall sbrdf determined using triangular faceted computer aided design cad model empirical sbrdf homogeneous materials cad model used determine proportional contribution homogeneous material overall reflectance empirical sbrdf contained look tables developed measurements made range illumination reflection geometries using simple interpolation extrapolation techniques demonstration spacecraft reflectance model provided simulation optical ground truth characterization using canadian advanced nanospace experiment engineering model nanosatellite subject validation reflectance model achieved qualitative comparison simulated measured quantities cospar published elsevier ltd rights reserved
training programmes incorporating isoinertial technology contributed considerable improvement developing muscle force muscle power objectives evaluate knee flexor extensor muscle force concentric eccentric contractions method week training programme sessions week using isoinertial technology implemented involving simultaneous flexion extension knees training programme lower body power evaluated using versapulley isoinertial technology separate knee extension flexion exercises data power velocity force work repetition times etc recorded monitored concentric eccentric contractions results significant improvement recorded concentric eccentric contractions knee flexion extension conclusions early stages functional recovery general exercise enhances adaptation limbs reducing asymmetry prompted sports injuries course physical recovery overload caused working separately affected limb diminished thus shortening recovery time
although many teaching techniques children autism spectrum disorder asd require instructor gain child eye contact prior delivering instructional demand literature contains notably procedures reliably produce outcome address problem evaluated effects sequential model increasing eye contact children asd model included following phases contingent praise eye contact contingent edibles plus praise stimulus prompts plus contingent edibles praise contingent video praise schedule thinning maintenance evaluations years results indicated procedures increased eye contact participants one additional participant require consequences participants praise alone sufficient support eye contact however high levels eye contact typically maintained participants therapists used combined schedules intermittent edibles video continuous praise discuss limitations model directions future research increasing eye contact children asd
several biologics currently fda approved asthma target high patients unfortunately patients severe asthma fit phenotype disease fewer effective therapeutic options clinical setting total ige feno peripheral blood eosinophils important tools defining high patients asthma however precise biomarkers predict better response one specific high asthma therapy versus another lacking important recognize none current medications targeting pathway induces persistent immunomodulation remission
prolonged exposure happy face makes subsequently presented faces appear sadder facial emotion aftereffect fea people autism spectrum disorders relatives diminished holistic perception faces levels autism measured continuously general population autistic traits using autism quotient prior work found association fea adults possibly due non holistic processing strategies employed higher end spectrum present study tested whether aqwas associated fea partially occluded faces hypothesized inferring emotion faces would require participants process viewable parts gestalt percept thus anticipated ability would diminish autistic traits increased experiment partially occluded adapting faces aligned misaligned opaque bars conditions produced significant feas aftereffects negatively correlated experiment adapted participants obscured faces flickering luminance manipulated facilitation holistic perception varying synchronization flickering found significant feas conditions abolished association experiment showed association fea occluded conditions experiment due recognizability perceived emotional intensity adaptors although overall feas linked emotional intensity propose increasing autistic traits associated diminishing abilities perceiving emotional faces gestalt percept elsevier ltd rights reserved
article deals evaluation designed controller named sliding mode control smc sliding surface controller integrated proportional integral derivative pid controller control scheme established derived dynamic equation stability proven lyapunov theorem performance assessment designed pid sliding surface controller parameter first obtained conventional tuning method known ziegler nichols compared particle swarm optimization pso computational tuning algorithm observation simulation results pso tuning algorithm showing outperform performances compared conventional tuning method term trajectory tracking electro hydraulic actuator eha system
background acupuncture practice important step confirm location sensitized acupoint reflects diagnosis stimulated specialized needle treat disease abnormal symptoms hyperalgesia allodynia sensitized acupoints patients visceral disorders considered relation referred pain neurogenic inflammation yet limited study investigated cutaneous neurochemical changes sensitized acuponits methods resent study developed animal model gastric mucosal injury gmi hcl administered stomach rats evans blue dye applied injection tail vein mucosal damage observe neurogenic plasma extravasation dots skin rats dots extravagated skin compared locations acupoints immnohistochemistry analysis used detect expression calcitonin gene related peptide cgrp substance labeled nerve fibers histamine serotonin tryptase labeled cells dots images recorded analyzed confocal imaging system olympus image processing software results results showed gmi resulted neurogenic plasma extravasation skin acupoints back abdomen mostly occurred dermatomere extravasation dots appeared gmi disappeared gradually natural self recovery gastric mucosa cgrp positive nerve fibers distributed dots regions beside dots control mostly distributed nerve fibers around vessels root hair follicle mast cells also aggregated degranulated release algogenic substances around vessels areas dots conclusions results indicates mechanism extravasation skin acupoints induced gmi closely related neurogenic inflammation high expression local allergic substances nociceptive neuropeptides local skin including cgrp mast cell tryptase may underlying mechanism acupoint sensitization
many challenges developing treatments complex diseases review explores question whether possible imagine data repository would increase pace understanding complex diseases sufficiently well facilitate development effective treatments first consideration given amount data might needed data repository whether existing data storage infrastructure enough several successful data repositories examined see common characteristics area science unsuccessful attempts develop data infrastructure described see lessons could learned data repository devoted complex disease variety issues related sharing data discussed areas reasonably clear move forward areas significant open questions need addressed data repositories using baseline information question whether data archives effective understanding complex disease explored major goal data archive likely identifying biomarkers define sub populations disease published elsevier ltd
background schizophreniform syndromes divided primary forms polygenic causes secondary forms due immunological epileptiform monogenic degenerative causes steroid responsive encephalopathy associated autoimmune thyroiditis sreat secondary immunological form associated increased thyroid antibodies antithyroid peroxidase antibodies shows good response corticosteroids case presentation present case year old woman suffering schizophreniform syndrome starting age developed psychotic exacerbations formal thought disorder acoustic hallucinations cenesthopathic experiences loss ego boundaries time began suffer chronic sexual delusions olfactory hallucinations respond neuroleptic medication levels antithyroid peroxidase antibodies slightly increased blood brain barrier disturbed electroencephalogram eeg showed intermittent generalized slowing cerebral magnetic resonance imaging cmri depicted mild temporolateral atrophy high dose corticosteroid treatment led convincing improvement attentional performance disappearance delusions olfactory hallucinations conclusion sreat mimic typical symptoms schizophreniform syndromes increased titer antithyroid peroxidase antibodies combination eeg slowing blood brain barrier dysfunction cmri alterations basis suspecting immunological cause patient chronic delusions olfactory hallucinations cognitive deficits successfully treated corticosteroids occurrence secondary immunological forms schizophreniform syndromes demonstrates need innovative immunosuppressive treatment options
herringbone water sediment separation structure hereinafter referred herringbone structure shown effective separating coarse inorganic debris however less known regarding large wood filtration effect structure paper presents preliminary research wood filtration effect herringbone structure based physical model tests results show herringbone structure exhibited effective performance large wood size segregation component filtration rate diameter larger ribbed beam opening width total filtration rate also exceeded fraud number larger increased increase exceeding max total filtration rate would decreased due overflow beside flow condition structure parameters influence significantly filtration rate attempt explain filtration process via particle contact trajectory particle movement trajectory inclined angle ribbed beam gamma contributed variation filtration rate via influencing coincidence particle contact trajectory particle movement trajectory high sensitivity coefficient ribbed beam theta relatively low conditions implies remarkable influences filtration effects causing clogging problem ribbed beam opening width together diameter influenced size segregation performance
zeolites fascinating versatile materials vital wide range industries due unique structural chemical properties basis applications gas separation ion exchange catalysis given economic impact powerful incentive smart design new materials enhanced functionalities maximizing application performance review article intends summarize published reports applications molecular simulation adsorption separation diffusion theoretical aspects adsorption thermodynamics adsorption isotherm comprehensively studied relation adsorption applications adsorbates characteristics influence adsorption review comprehensively discusses theoretical computational aspects diffusion pure components long chain hydrocarbons mixture diffusion including molecular dynamics simulations kinetic monte carlo furthermore cation zeolite adsorbate interactions thoroughly examined elucidate role cations zeolites applications cation exchange influences structural dynamics properties zeolites study also focuses role cations gas liquid adsorption separations elsevier inc rights reserved
paper first apply cosine radial basis function neural networks solve fractional differential equations initial value problems boundary value problems examples successfully obtained numerical solutions fractional riccati equations fractional langevin equations computer graphics numerical solutions show method effective
paper mathematical model induction generator based distributed electrical parameters presented transient electromechanical processes occurring power system analyzed case unbalanced lagging load interdisciplinary method coming modification hamilton principle used order formulate state differential equations numerical simulations made results simulations presented paper graphs
cannibalism intraspecific predation play major role changing individual fitness population processes insects cannibalism frequently occurs across life stages cannibals consuming smaller vulnerable stage predation adult insects one another considered uncommon investigated adult cannibalism colorado potato beetle leptinotarsa decemlineata say oligophagous herbivore specializing plants family solanaceae important agricultural pest laboratory conditions starvation crowding encouraged teneral adults feed upon reduced weight loss period starvation however pupae attacked consumed adults injured beetles higher probability cannibalized intact beetles males frequently attacked females appeared function smaller size rather gender specific traits cannibalizing eggs larval stage affect beetle propensity cannibalize adults adult stage given choice conspecific adults mealworms beetles preferred eat conspecifics cannibalistic behavior including adult cannibalism could important population persistence species
background vietnam concentrated hiv epidemic injection drug use dominant mode hiv transmission vietnam rapidly expanded antiretroviral therapy art methadone maintenance therapy mmt study aims analyze art uptake retention among male clients receiving mmt vietnam early phase mmt program methods male clients age newly enrolled care started art two hiv clinics hanoi three hiv clinics tho included analysis lymphocyte count hiv care enrollment art initiation retention art retrospectively analyzed values receiving mmt compared values two groups injection drug use idu status documented receiving mmt male clients receiving mmt analyze retention survival analysis log rank test cox proportional hazard model used results study period adult men newly enrolled hiv care idu status documented initiated art idu status documented among initiated art receiving mmt care enrolment receiving mmt median count iqr cells men self reporting idu receiving mmt men receiving mmt median count iqr cells iqr cells respectively art initiation men receiving mmt significantly higher count median iqr cells men self reporting idu receiving mmt iqr cells men receiving mmt iqr cells receiving mmt significantly higher retention rate self reporting idu receiving mmt hazard ratio men receiving mmt hazard ratio conclusions analysis suggests men receiving mmt vietnam achieving relatively early uptake high retention rates art findings support potential benefits integrating mmt art services vietnam
angiotensin converting enzyme ace gene established substantial attention recent years candidate gene hypertension cardiovascular diseases type diabetes aim present study investigate association ace polymorphism coronary artery disease cad north indian population total subjects cad patients healthy controls examined association ace gene polymorphism environmental risk factors mean age cad patients control subjects years years respectively anthropometric demographic data showed bmi values significantly higher among cad patients control subjects observed pronounced central obesity cad patients controls even lowest bmi values dyslipidemia highly prevalent cad patients compared control subjects genotypic data showed significantly higher frequency genotype cad patients control subjects significant difference observed distribution genotypes cad patients control subjects logistic regression analysis data demonstrate genotype associated fold increased risk development cad asian indians frequency allele significantly higher cad patients significant difference observed clinical biochemical characteristics cad patients controls data stratified according genotypes ace gene conclusion genotype ace gene may associated increased risk cad asian indian population
cereal based foods key components diet dominate food based dietary recommendations order achieve targets intake carbohydrate protein dietary fibre processing milling grains produce refined grain products removes key nutrients phytochemicals flour although countries nutrients may replaced mandatory fortification overall refinement reduces potential nutritional quality increasing evidence observational intervention studies increased intake less refined whole grain foods positive health benefits highest consumers consistently shown lower risk developing cvd type diabetes cancers consumers may also better digestive health likely lower bmi gain less weight time bulk evidence benefits comes observational studies evidence benefit intervention studies potential mechanisms action increasing overall evidence supports promotion foods refined grain foods diet would require adoption standard definitions whole grain whole grain foods enable innovation food manufacturers provide clarity consumer encourage implementation food based dietary recommendations public health strategies
apoptosis dna oxidative damage serve significant roles pathogenesis steroid induced femoral head necrosis vitamin demonstrates anti apoptotic anti oxidant properties therefore present study investigated effects vitamin osteocyte apoptosis dna oxidative damage bone marrow hemopoietic cells early stage steroid induced femoral head osteonecrosis japanese white rabbits randomly divided three groups steroid vitamin treated control groups comprising rabbits steroid group group initially injected twice intravenous dose escherichia coli endotoxin interval two injections intramuscular dose methylprednisolone three times intervals order establish rabbit model osteonecrosis vitamin treated group group received treatment group administered vitamin daily beginning modeling control group group injected normal saline equivalent dosage times aforementioned two groups two time points weeks following completion modeling selected osteonecrosis verified histopathology hematoxylin eosin staining apoptosis rate osteonecrosis analyzed terminal deoxynucleotidyl transferase dutp nick end labeling assay apoptosis expression levels caspase cell lymphoma bcl dna oxidative damage bone marrow hematopoietic cells analyzed immunohistochemistry weeks following completion modeling vacant bone lacunae rates group respectively lower results group osteocyte apoptosis indexes group respectively lower results group addition bcl expression week femoral head tissues group higher compared group proportion bcl positive cells group higher compared group caspase staining data week femoral head tissues demonstrated femoral heads group four negative eight positive group five negative seven positive group negative one positive addition dna oxidative damage rate week bone marrow hemopoietic cells group lower compared group higher compared group vitamin effective intervening apoptosis decreasing caspase expression upregulating bcl expression alleviating dna oxidative damage bone marrow hemopoietic cells early stage steroid induced femoral head necrosis rabbit models
variational lagrangian formulation stochastic processes evolution equations associated probability density functions developed particular attention dedicated poisson kac processes possessing finite propagation velocity variational formulation terms lagrangian hamiltonian densities permits address different forms reversibility characterizing processes respect processes driven nowhere differentiable wiener fluctuations associated concepts dynamic statistical reversibility latter property statistical reversibility implies extended markov operator associated poisson kac generalized poisson kac processes forms group continuously parametrized respect time elsevier rights reserved
despite popularity strategy video games poorly studied social science strategy video games require long gaming sessions planning management resources reaching long term goals assumed would function virtual training center self regulation abilities every day life adopting strength model self control theoretical framework baumeister vohs tice two cross sectional studies examined extent playing strategy video games predicts self regulation study found positive significant association strategy video game play controlling impact video game genres self regulation study deepened relationship controlling effects personality traits individual preferences age gender satisfaction life avoidance temptations need cognition risk taking impulsiveness big overall frequency exposure video games study playing strategy video games positively associated self regulation moreover relation statistically held controlling impact individual personality differences implications future directions discussed elsevier ltd rights reserved
background nasal nitrous oxide nno increased allergic rhinitis asthma non invasive marker inflammation nasal passages methods levels nno measured compared healthy children children mild moderateto severe levels nno treatment steroids antihistamine compared groups relationship quality life nasal symptom reactivity outdoor outdoor allergens examined results nno levels higher mild healthy children higher moderate severe mild one month steroid antihistamine treatment lowered nno levels control levels mild approximately halfway control levels moderate severe nno levels weak correlation quality life questions fair correlation nasal symptom scores treatment correlation weakened lost treatment correlation seen nno levels responses indoor outdoor allergens conclusion nno levels children may useful assessing response treatment relationship quality life nasal symptoms sensitivity specific allergens needs study
factorization polynomials one foundations symbolic computation applications arise numerous branches mathematics sciences however present advanced programming languages support symbolic computation directly hence leads difficulties applying factorization engineering fields paper authors present algorithm use numerical method obtain exact factors bivariate polynomial rational coefficients proposed method directly implemented efficient programming language together gnu multiple precision library addition numerical computation part often requires double precision easily parallelizable
main goal map ability interrogators register manifestations nonverbal communication situation testimony secondary goal analyse aspects process identification manifestations nonverbal communication research aimed area described available literature sources theoretical description general terms use non verbal communication application level research practically known although reality confirm file records interrogations contain part described nonverbal expressions interrogated person ability tested presentation short sequences nonverbal communication record denoting book sheet analytical part work offer results examination study partial output research methods procedure crime scene vysk authors published elsevier ltd
chapter report two studies grade students used distributed computing infrastructure vimap tangible order collaboratively invent mathematical machines generating geometric shapes vimap tangible combines vimap visual programming language distributed computing infrastructure students collaboratively control behavior virtual agent using mechanical devices virtual algorithms curricular activities integrate engineering practices user centered design agent based computer programming mathematical reasoning multiplication rates geometry physical science concepts central learning newtonian mechanics study investigate key affordances distributed computing environment learning integrated stem identify relationships various elements students physical constructions computational models stem learning outcomes study deeper investigation effect iterative user testing refinement children designs stem learning
objective objectively assess seated non exercise physical activity patients anorexia nervosa relative healthy controls hcs examine associations physical activity eating disorder pathology levels anxiety depression method eleven inpatients hcs wore shoe based accelerometer smartshoe three time points eating lunch filling questionnaires watching television results across three tasks patients significantly active hcs thereby engaging greater degree restless fidgeting behavior degree physical activity positively correlated eating disorder psychopathology sample trend towards positive association physical activity levels depression anxiety also found sample among individuals physical activity significantly correlated bmi duration illness number days since hospital admission discussion use minimally invasive shoe based monitor revealed patients engaged greater degree fidgeting relative hcs quiet seated tasks heightened activity related measures pathology non exercise physical activity including fidgeting may warrant clinical attention patient population elsevier ltd rights reserved
humans fish consumption major source mercury exposure aim study assess effect peacock blenny salaria pavo species family blennies used indicator water pollution performed sublethal contamination fish hgcl days concentration measured experimental water much lower nominal concentration also measured gill liver tissues displays significant increase concentration gills day exposure followed decrease throughout experiment liver burden reaches maximum day followed also decrease partial length cdna gpx cat mnsod cuznsod characterized results mrna expression levels displayed regulation gpx mnsod downregulation cat observed several biomarker activities determined gills liver exposure affected antioxidant enzymes gills erod gst gpx significantly decreased cat levels increased days exposure lipid peroxidation lpo induction observed gills exposed fish regarding liver activity enzymes increased significantly beginning experiment lpo induction however induced days histological analysis also performed indicated fish exhibited several damages gills liver mainly relation circulatory disturbances gills regressive changes liver biomarkers assessed showed peacock blennies able detoxify gill liver tissues developing various defense mechanisms
recent increase youth sports participation single sport youth athletes past years increase number acute overuse sports injuries population review focuses overuse traumatic injuries shoulder elbow young athletes particular discuss little league shoulder glenohumeral internal rotation deficit glenohumeral instability superior labrum anterior posterior lesions little league elbow panner disease osteochondritis dissecans capitellum posteromedial elbow impingement posterolateral rotatory instability elbow significant emphasis evaluation management upper extremity injury overhead thrower
concept dispersion code modulation dcm introduced enhancing spectral efficiency wireless communications nth order dcm modulation scheme splits data streams channels distinct dispersion codes hence increases throughput factor order dcma system based physical models demonstrated
estuary plumes western louisiana continental shelf gulf mexico outside constricted channels sabine calcasieu lakes observed two radarsat synthetic aperture radar sar images situ data showed change salinity similar psus across front northwest edge plume corresponding locations vertical salinity variation psu velocity magnitude outside inlet reached seaward brackish lens upper water column spread contributed development plume volume brackish water within plume estimated order magnitude larger volume output calcasieu river within entire ebb tidal period implies plume formed multiple tidal cycles sustained flood tides weak diurnal tides exist satellite situ observations showed interesting western intensification plume analysis momentum vorticity equations suggests western intensification due asymmetry vorticity divergence relationship coriolis force also enhanced ambient coastal current strengthens convergence front estuary plumes shown bright dark features two sar images results radar model simulation situ water temperature data showed sar observed plume features dominated water temperature differences
restricted mobility major issue individuals knee osteoarthritis total knee arthroplasty tka expected improve mobility people knee alleviating pain improving walking ability present study aimed describe time course mobility tka identify factors affecting mobility tka prospective cohort study comprised patients undergoing tka evaluated month preoperatively well months postoperatively outcome measures included mobility life space assessment lsa self efficacy walking tasks modified gait efficacy scale mges physical quadriceps strength timed tug test knee function knee society score questionnaire result total patients mean age years range years completed postoperative assessments compared preoperative values patients showed decreased lsa mges scores month postoperatively found improvements scores month month assessment however difference lsa mges scores preoperative month assessment also found improvements quadriceps strength tug score knee society score pain scores preoperative month assessment additionally months postoperatively mges tug scores significantly affected mobility results suggest mobility months tka similar preoperative level self efficacy walking tasks functional ability important factors improving mobility tka
bark beetles important agents tree mortality conifer forests interaction trees influenced host defense chemicals monoterpenes phenolics since mountain pine beetle dendroctonus ponderosae hopkins expanded host range lodgepole pine pinus contorta doug loud var latifolia engelm dominated forests novel jack pine pinus banksiana lamb forests western canada studies investigating jack pine suitability host beetle exclusively focused monoterpenes whether phenolics affect jack pine suitability mountain pine beetle symbiotic fungus grosmannia clavigera unknown investigated phenolic monoterpene composition phloem foliage jack lodgepole pines subsequent change response water deficit clavigera inoculation treatments lodgepole pine phloem water deficit treatment inhibited accumulation total richness phenolics effect total monoterpene production richness fungal infection also inhibited total phenolic production effect phenolic monoterpene richness increased total monoterpene synthesis jack pine phloem water deficit treatment reduced phenolic production effect phenolic monoterpene richness total monoterpenes fungal infection affect phenolic monoterpene production lesions species contained lower phenolics higher monoterpenes non infected phloem tree species richness monoterpenes phenolics greater non infected phloem lesions conclude monoterpenes seem critical component induced defenses clavigera jack lodgepole pines however lack increased monoterpene response fungal infection important evolutionary factor defining jack pine suitability mountain pine beetle invasion western canada
computational fluid dynamic models based limpet owc turbo generation section created investigate airflow impingement created rotating turbine directly upstream increased heat transfer away electrical generator could increased adjusting clearance turbine tips shroud found reducing clearance consistent beneficial effects turbine performance generator cooling due greater utilisation airflow tip gap
effect urea injection nox emissions six cylinder four stroke internal combustion engine fueled biodiesel experimentally investigated results reveal urea injection leads reduction nox emissions biodiesel fuel moreover influence injection parameters nox reductions studied findings show increasing injection temperature results lower nox emissions also urea mass flow rate increment leads nox reduction result obtained increase spray angle addition increasing number nozzles indicates depletion nox emissions three nozzles spray system considerable effect nox reductions energy institute published elsevier ltd rights reserved
data parallel skeleton libraries implementation skeletons usually tightly coupled data structures however loose coupling like stl improve modularity flexibility skeletons data structures flexibility particularly valuable tree skeletons achieve loose coupling present iterator based interface trees tree skeletons implemented tree skeletons basis interface present design implementation paper also reports results preliminary experiments
background vertically oriented global health initiatives ghis addressing hiv aids epidemic including president emergency plan aids relief pepfar successfully contributed reducing hiv aids related morbidity mortality however still debate whether disease specific programs improved harmed health systems overall especially respect non hiv health needs methods part larger evaluation pepfar effects health system collected qualitative quantitative data semi structured interviews district health officers dhos districts uganda asked dhos share perceptions ways hiv programs largely pepfar ugandan context helped harmed health system identified key themes among responses using qualitative content analysis results ugandan dhos said pepfar generally helped health system improving training integrating hiv non hiv care directly providing resources lesser extent dhos said pepfar caused health system focus narrowly hiv aids increased workload already overburdened staff encouraged doctors leave public sector jobs higher paid positions hiv aids programs conclusion health system leaders uganda district level appreciative resources aimed hiv could often apply broader purposes hiv infection becomes chronic disease requiring strong health systems manage sustained patient care time uganda weak health systems require broad infrastructure improvements inconsistent narrow vertical health programming
wing wave ocean alternative energy system convert circular motion ocean waves propagate sea electrical energy system consists planes called wings wings mounted sea floor move radial motion result passing waves mechanical energy translated electrical energy means electrical generator three wing wave prototype systems built florida institute technology florida tech deployed november june june respectively deployment provided valuable information lead modifications subsequent versions deployment techniques culminating demonstration fully functioning feasible alternative renewable electrical energy producing subsea system
paper presents design test results biaxial excitation generator motor automobiles bega three phase stator salient pole excited heteropolar rotor multiple flux barriers filled low cost permanent magnets pms new generator low voltage regulation obtained flux barrier combination field excitation low power control full power diode rectifier stator good power volume superior efficiency obtained costs comparable existing lundell generator generator configuration principle equations finite element field analysis design optimization performance characteristics test results together generating system simulations constitute core paper
recurrence meningitis due cryptococcus neoformans treatment causes substantial mortality hiv aids patients across sub saharan africa order determine whether recurrence occurred due relapse original infecting isolate reinfection different isolate weeks months initial treatment used whole genome sequencing wgs assess genetic basis infection hiv infected individuals recurrent cryptococcal meningitis comparisons revealed clonal relationship pairs isolates recovered recurrence showing relapse original infection two remaining pairs showed high levels genetic heterogeneity one pair found result infection mixed genotypes second result nonsense mutations gene encoding dna mismatch repair proteins msh msh rad nonsense mutations led hypermutator state leading dramatically elevated rates synonymous nonsynonymous substitutions hypermutator phenotypes owing nonsense mutations genes previously reported neoformans represent novel pathway rapid within host adaptation evolution resistance first line antifungal drugs
proportional integral derivative pid controllers popular control systems equipped industries due simplicity effectiveness functionality article adaptive differential evolution algorithm presented tune controller parameters pid systems proposed algorithm uses shift based parameter control pseudo population reduction procedures algorithmic parameters adapted additional parameter introduced set three typical control instances taken study performance proposed algorithm four recently reported algorithms chosen baselines numerical experiment turns proposed algorithm yields better performance four baseline algorithms moreover proposed algorithm better scalability reliability test algorithms
existing automated compliance checking acc systems limited automation rely use hard coded proprietary rules representing regulatory requirements requires major manual effort extracting regulatory information textual regulatory documents coding information rule format address limitation paper proposes new unified acc system integrates semantic natural language processing techniques express data based techniques automatically extract transform regulatory information regulatory documents design information building information models bims automated compliance reasoning semantic logic based information representation reasoning could fully automated test proposed system bim test case checked compliance chapter international building code comparing manually developed gold standard recall precision noncompliance detection achieved elsevier rights reserved
background child abuse health social problem screening instruments available detection risk primary health care aim develop screening instrument used professionals public health care sector thus enabling detection infants toddlers risk emotional physical abuse neglect provide evidence feasibility instrument cyprus greece spain method total health professionals paediatric public health care centres three countries involved three step process guiding development screening tool application results nine item screening tool consisting items assessing relational emotional abuse physical abuse risk factors developed screening tool applied total families year old children attending public health centres three countries clinicians reported agreed inclusion questions found questions useful clinical evaluation family conclusion screening tool shows considerable face validity reported feasible international set clinicians
purpose study explore link political affinity source credibility perception cases fox news npr based third person perception framework study combines methodology focus group interviews investigate interaction audience source shaping credibility media source results confirmed third person perception audiences tend perceive politically aligned news channel trustworthy fails attain social impact deserves contrast audiences perceive hostile news channel social impact although trustworthy
hierarchial aminated polyacrylonitrile aopan composite nanofibrous membrane obtained electrospinning technique surface modification hydroxylamine chloride prior hydro thermal method composite nanofibrous membranes characterized fourier transform infrared spectroscopy ftir scanning electron microscopy sem ray diffraction xrd transmission electron microscope tem confirm formation nanoparticles aopan nanofibers results revealed degrees best hydrothermal condition nanoparticles effectively load surface aopan nanofibrous membrane adsorption process showed dependence maximum adsorption occurred langmuir adsorption model described well experimental adsorption data estimated maximum loading capacity mainly due protonation groups nanoparticles acid condition benefit adsorbing hcro kinetics studies indicated adsorption equilibrium attained experimental data followed pseudo second order model meanwhile aopan composite nanofibrous membrane easily separated liquid solutions shows excellent cyclic utilization per formance composite membrane maintained removal rate rinsing dilute naoh solution four cycles therefore aopan composite nanofibrous membrane could good candi date removing wastewater study provides simple effective route develop ment new environmental remediation nanomaterials
backgroundwhile studies mindfulness based stress reduction mbsr youth recently emerged shortage research adolescents clinical populations experience mbsr purpose qualitative study explore impact mbsr subjective perspective adolescents serious mental health concerns methodadolescents residential treatment center participated adapted week mbsr program learned range mindfulness skills encouraged apply skills everyday lives end program month follow youth participated semistructured interviews asked describe impact program perspectives basic interpretive qualitative analysis methods used code data group codes higher level themes resultssix main themes found including improved mood enhanced relationship self increased self control improved problem solving awareness present enhanced interpersonal relationships discussionresults study suggest mbsr program perceived beneficial short term follow several aspects emotional cognitive interpersonal functioning
linear switched reluctance machines lsrm relatively low force output high force ripples paper discusses double sided linear hybrid switched reluctance machine lhsrm includes permanent magnets embedded stator leg slots proposed lhsrm hybrid excitation flux circuits derived permanent magnets external current excitations machine design based equivalent magnetic circuit analysis performance evaluation carried finite element methods fem simulation results demonstrate lhsrm better propulsion force output performance reduced force ripples compared pure lsrm without pms dimensions experimental measurement results verify proposed linear machine possesses higher average force lower force ripple factor
developing effective treatments preventing inflammatory bowel disease ibd urgent challenges improving patients health suggested platelet activation reactive oxidative species generation involved pathogenesis ibd examined inhibitory effects selective phosphodiesterase inhibitor cilostazol two antioxidants enzymatically modified isoquercitrin emiq alpha lipoic acid ala dextran sulphate sodium dss induced colitis balb mice treated emiq ala feed colitis induced administering dss drinking water days inhibitory effects substances evaluated measuring relevant clinical symptoms faecal blood diarrhoea body weight loss colon length plasma cytokine chemokine levels whole genome gene expression histopathology diarrhoea suppressed treatment prevented shortening colon length treatment groups exhibited decreased plasma levels interleukin tumour necrosis factor tnf alpha compared dss group microarray analysis showed cell adhesion cytoskeleton regulation cell proliferation apoptosis might related inflammatory cell infiltration mucosal healing affected groups dss induced mucosal injuries mucosal loss submucosal oedema inflammatory cell infiltration distal colon prevented antioxidant treatment results suggest anti inflammatory effects agents reduced dss induced mucosal injuries mice therefore may provide therapeutic benefits ibd elsevier gmbh rights reserved
misremembering systematic ordinary occurrence daily lives since commonly assumed function memory remember past misremembering typically thought happen memory system malfunctions paper argue cases misremembering due failures memory system particular argue many ordinary cases misremembering seen instances memory malfunction rather normal result larger cognitive system performs different function remembering one operation building upon extant psychological neuroscientific evidence offer picture memory integral part larger system supports thinking case potentially could case also could case precisely claim remembering particular operation cognitive system permits flexible recombination different components encoded traces representations possible past events might might occurred service constructing mental simulations possible future events
objectivethe aim study optimize synthesis plasmin urokinase upa inhibitor benzylsulfonyl ser homophe amidino benzylamide bsfab characterize activity mechanism action assess use improve stratum corneum barrier function methodspeptide coupling methods used synthesize bsfab high performance liquid chromatography mass spectrometry hplc together nuclear magnetic resonance spectroscopy nmr applied clarify structure determine purity binding mode determined docking studies catalytic domains plasmin upa inhibition constants determined enzyme kinetic studies effect bsfab plasmin upa transglutaminase expression evaluated non cytokine cytokine stimulated keratinocytes vehicle controlled clinical study barrier function conducted facial skin subjects self perceived sensitive skin resultsbsfab synthesized high purity silico studies indicated amidine moiety bsfab anchored pocket enzymes binding asp ser gly whereas backbone ser residue makes anti parallel sheet interaction gly bsfab shown effective inhibitor plasmin upa values respectively bsfab also inhibited keratinocyte secreted protease activities basal plasmin inhibition upa inhibition cytokine induced conditions plasmin inhibition upa inhibition stimulated gene expression transglutaminase cytokine stimulated keratinocytes approximately times increased expression clinically bsfab shown improve barrier integrity day subjective improvements perception healthy skin day conclusionbsfab binds reversible competitive inhibitor active sites plasmin upa additionally bsfab positively improved keratinocyte differentiation gene expression transglutaminase effects translated improvements barrier integrity clinically subjects dry sensitive skin improved perception healthy skin condition resume objectifle cette etude etait optimiser synthese inhibiteur plasmine urokinase upa benzylsulfonyl ser homophe amidino benzylamide bsfab pour caracteriser son activite mecanisme action evaluer son utilisation pour ameliorer fonction barriere stratum corneum methodesles methodes couplage peptidique ont ete utilisees pour synthetiser bsfab chromatographie liquide haute performance spectrometrie masse clhp avec spectroscopie resonance magnetique nucleaire rmn qui servent clarifier structure determiner purete ont ete employees son mode liaison ete determine par etude amarrage aux domaines catalytiques plasmine upa les constantes inhibition ont ete determinees par des etudes cinetique enzymatique effet bsfab sur plasmine upa expression transglutaminase ete determine chez les keratinocytes stimules par les cytokines non une etude clinique controlee contre placebo sur fonction barriere ete realisee sur peau visage des sujets peau sensible auto percue resultatsle bsfab ete synthetise avec une purete elevee les etudes silico ont indique que groupement amidine bsfab ete ancre dans poche deux enzymes par liaison asp ser gly alors que squelette residu ser fait feuillet interaction avec gly antiparallele bsfab est montre etre inhibiteur efficace plasmine upa avec des valeurs respectivement bsfab egalement inhibe les activites des proteases keratinocytaires secretees dans les conditions base plasmine inhibition upa inhibition des conditions induites par cytokine plasmine inhibition upa inhibition stimule expression gene transglutaminase dans les keratinocytes stimules par des cytokines une expression accrue environ fois cliniquement bsfab ete permis ameliorer integrite barriere jour apporter des ameliorations subjectives dans perception peau saine jour conclusionbsfab lie comme inhibiteur competitif reversible aux sites actifs plasmine upa outre bsfab ameliore positivement expression gene differenciation des keratinocytes transglutaminase ces effets ont ete traduits ameliorations dans integrite barriere cliniquement chez les sujets ayant une peau seche sensible ont ameliore leur perception avoir une condition peau saine
objectives although mobility aids crutches walkers wheelchairs typically beneficial associated injury objective study describe incidence patterns trends pediatric mobility aid related injuries children adolescents aged years treated emergency departments methods retrospective analysis conducted using data national electronic injury surveillance system database children adolescents aged years sample weights used calculate national estimates mobility aid related injuries basis actual cases results estimated cases children adolescents aged years treated emergency departments mobility aid related injuries approximately mobility aid related injuries occurred patients using wheelchairs children aged years likely sustain injuries using walkers wheelchairs injure heads sustain traumatic brain injuries children aged years likely sustain injuries using crutches injure lower extremities sustain sprains strains injuries involving wheelchairs likely traumatic brain injuries result hospitalization injuries involving crutches likely involve misuse triggered stairs curbs conclusions injuries related crutches walkers wheelchairs distinct injury patterns mechanisms injury trigger factors injury patterns younger older children different additional research needed identify effective injury prevention strategies pediatric population pediatrics
background objectives pulmonary aspergillosis serious fungal infection etiological agent fungi genus aspergillus infection mainly affects immunocompromised individuals high mortality rate among related difficult diagnosis treatment due difficulty obtain positive results aspergillus traditional methods laboratory culture becomes necessary evaluate alternative techniques detection microorganism one advances diagnosis aspergillosis galactomannan test detects fungal cellular membrane polysaccharide released host bloodstream infection methods study consisted analysis hospitalized patients period tertiary hospital rio grande sul state brazil epidemiological analysis following data patients collected age sex hospitalization unit underlying disorders clinical radiological data antimicrobial use results galactomannan test results patients showed positive results galactomannan test individuals prolonged neutropenia mainly result hematologic malignancies persistent fever despite use broad spectrum antibiotics main clinical sign associated suspected invasive pulmonary aspergillosis conclusion study established clinical profile patients suspected api characterized prolonged fever neutropenia
authors report year old gravida para claimed menarche age menopause years two months prior presentation subject first noticed hard elastic fist sized mass left inguinal region gradually grew causing pressure related pain although external genitalia appeared female vagina short blind ending uterus ovaries identified transvaginal ultrasound chromosome banding results band method showed laparoscopy revealed traces vestigial uterus ovaries thus based appearance external genitalia diagnosis testicular feminization syndrome made pathological testing palpable mass led diagnosis seminoma leydig cell hyperplasia thus case development seminoma undescended testis led detection testicular feminization syndrome
report fabrication imaging quality optical mirrors smooth surfaces using carbon nanotubes embedded epoxy matrix cnt epoxy multifunctional smart composite material sensing capabilities made incorporate self actuation well moreover since precursor low density liquid large lightweight mirrors fabricated processes replication spincasting printing technology therefore holds promise development new generation lightweight compact smart telescope mirrors figure sensing active adaptive figure control report measurements made optical mechanical characteristics discuss possible paths future development
restrain influence armature reaction flux barriers added rotor structure enhance output power ability brushless doubly fed machine design scheme brushless doubly fed machine barrier rotor provided based field circuit coupled finite element method asynchronous operation performance brushless doubly fed machine barrier rotor studied condition load including adjusting voltage adjusting speed series resistance adjusting voltage prototype carried condition load asynchronous operation comparison analysis simulation speed values tested speed values realized designed machine reasonable reliable
whether cumulative stress including chronic stress adverse life events associated decreased heart rate variability hrv non invasive measure autonomic status predicts poor cardiovascular outcomes unknown healthy community dwelling volunteers mean age years participated cumulative stress adversity interview cai item event interview measuring cumulative adversity including major life events life trauma recent life events chronic stressors underwent ambulatory ecg monitoring hrv analyzed frequency domain standard deviation intervals sdnn calculated initial simple regression analyses revealed total cumulative stress score chronic stressors cumulative adverse life events cale inversely associated ultra low frequency ulf low frequency vlf low frequency power sdnn hierarchical regression analyses total cumulative stress chronic stress significantly associated sdnn ulf even highly significant contributions age sex covariates accounting additional appreciable variance vlf total cumulative stress chronic stress significantly contributed variance alone longer significant adjusting race health behaviors summary total cumulative stress components adverse life events chronic stress associated decreased cardiac autonomic function measured hrv findings suggest one potential mechanism stress may exert adverse effects mortality healthy individuals primary preventive strategies including stress management may prove beneficial
objective examine whether cumulative family discrimination acculturation stress prenatally months postpartum among mexican origin adolescent mothers mother figures predicted children socio emotional functioning academic achievement years age role maternal depressive symptoms mother child interactions association method mexican origin families adolescent mother child mother figure participated wave longitudinal study families recruited interviewed adolescent mother pregnancy adolescent mothers mother figures children assessed annually next years using combination interview based survey observational methods maternal reports children socio emotional behaviors measured using child behavior checklist children academic achievement assessed woodcock johnson iii tests achievement bateria iii woodcock munoz used results structural equation modeling revealed greater cumulative family discrimination acculturation stress pregnancy months postpartum predicted higher adolescent mothers depressive symptoms greater mother child intrusive interactions less mother sensitivity months postpartum maternal depressive symptoms positively related children cbcl symptoms months postpartum greater cumulative discrimination acculturation stressors directly predicted children lower woodcock johnson bateria test scores accounting socio economic status conclusion mexican origin adolescent mothers mother figures cumulative discrimination acculturation stress pregnancy children second birthday predicted children socio emotional academic achievement age overall findings underscore cumulative impact stressors well population substantial public health significance
infantile anorexia defined diagnostic classification mental health developmental disorders infancy early childhood revised zero three occurs child refuses eat adequate amounts food least month shows growth deficiency communicate hunger lacks interest food child food refusal follow traumatic event due underlying medical illness usually emerges transition self feeding child issues autonomy played daily feeding situation studies evidence feeding interactions children mothers characterized low reciprocity greater interactional conflict negative affects chatoor ammaniti moreover studies pointed maternal depression eating disorders frequently associated cooper ammaniti lucarelli date research focused almost exclusively mother child dyad fathers involvement parental family interactions poorly studied current study pilot research investigated mother father child triadic interactions feeding play families children diagnosed comparison families normally developing children study participated families five child diagnosis five lack child diagnosis matched child age gender parents child triadic interactions assessed feeding play contexts using lausanne trilogue play fivaz depeursinge corboz warnery adapted observe father mother infant primary triangle feeding context compared play context lucarelli families group showed difficulties expressing sharing pleasure positive affects structuring predictable flexible context children showed little autonomy difficulty actively engaged tune parents dysfunctional family interactions critical issue affects parental family subsystems stressing importance articulated diagnostic assessment order target effective treatment approaches
cytokine interferon ifn alpha induces wide spectrum anti viral mediators via janus kinase signal transducer activator transcription jak stat pathway stat stat well characterised upregulate ifn stimulated gene isg expression even though stat also activated ifn alpha role anti viral isg induction unclear several viruses including hepatitis mumps reduce cellular stat protein levels via promotion ubiquitin mediated proteasomal degradation viral immune evasion mechanism suggests undiscovered anti viral role stat ifn alpha signalling investigate stat functional involvement type ifn pathway first analysed effect upon replication two viruses influenza vaccinia viral plaque assays using wild type stat murine embryonic fibroblasts mefs revealed stat required inhibition influenza vaccinia replication furthermore stat shrna knockdown also enhanced influenza replication hindered induction several well characterised anti viral isgs pkr oas mxb isg stat expression effect upon induction separate isg group viperin ifi cxcl ccl discoveries reveal first time anti viral role stat ifn alpha pathway characterise requirement stat expression specific isgs findings also identify stat therapeutic target viral infection highlight essential pathway component endogenous therapeutic ifn alpha responsiveness
objective vertigo symptoms lead less vertigo related handicap longitudinal study investigated whether depression anxiety somatization mediate relationship vertigo symptoms vertigo related handicap methods patients vertigo dizziness provided complete data following measures vertigo symptoms baseline depression month follow anxiety month follow somatization month follow vertigo handicap month follow mediation analyses bootstrapping performed investigate mediating role anxiety depression somatization relationship vertigo symptoms vertigo related handicap results mediating role anxiety depression somatization evaluated separately single mediation models effect vertigo symptoms baseline exerted vertigo related handicap month follow significantly mediated depression month follow anxiety month follow well somatization month follow statistically controlling mediators amultiple mediator model depression month follow mediated effect vertigo symptoms baseline vertigo related handicap month follow conclusion psychological distress important mechanism process vertigo symptoms lead vertigo related handicap elsevier inc rights reserved
paper analyses whether china export vat rebates export taxes driven environmental concerns since china struggles enforce environmental regulation trade policy used second best environmental policy general equilibrium model possible show second best export tax increases product pollution intensity empirical analysis investigates whether export tax equivalent partial vat rebates export taxes higher products pollution intensive along several dimensions results indicate vat rebate rates set way discourages exports water pollution intensive intensive energy intensive products moreover conservation natural resources minerals metals wood products precious stones seems key determinant china export vat rebate rates little evidence export taxes motivated environmental concerns author published elsevier inc open access article license http creativecommons org licensesiby
spatio temporal variation black carbon mass concentration total aerosol optical properties simulated regional climate model regcm versions investigated compared situ remote sensing measurements higher mass concentrations found indo gangetic basin igb versions mass regcm closer observations mass estimated regcm found agree within respect observation pre monsoon monsoon seasons differences observed simulated mass winter locations winter post monsoon western india suggests need improvement emission inventory region emissions biofuel crop residue burning agriculture low emission inventories regcm simulated aerosol optical depths aods found underestimation winter post monsoon kanpur overestimates aod pre monsoon monsoon seasons kanpur seasons except winter gandhi college single scattering albedo ssa values range lower ssa values found igb anthropogenic emissions dominate ssa simulated regcm lowered respect aerosol robotic network aeronet derived ssa moreover winter differences higher regcm simulated mass concentrations nearer observations columnar optical properties regcm close measurement mass closer observations model ozone related chemical tracers chemical transport model chemical boundary condition utilized addition cam earth
paper presents signal flow graph nonlinear modeling two cell cascade buck converters systematic procedure developing unified flow graph model cascade converter discussed simplified procedure described used deduce large small signal steady state models unified signal flow graph converter converter performance expressions small signal steady state transfer functions derived large signal model developed programmed tutsim simulator converter large signal responses obtained supply load disturbances validity proposed signal flow graph modeling cascade converters verified comparisons made via psim simulator results experimental results provided verify proposed method
increase food allergies worldwide led mounting concern among healthcare providers families schools food industry particular interest growing prevalence peanut allergy learning early peanut allergy leap study confirms early introduction peanut significantly decreases risk developing peanut allergy among high risk children however number issues unified definition high risk whether screen patients peanut introduction remain article review leap findings new peanut allergy prevention guidelines briefly discuss recommendations introduction allergenic foods based results food allergy prevention randomised controlled trials
work aims elucidate notions concerning ideal operation greenhouse gas ghg emissions benefits combined heat power chp systems investigating various metrics change function ghg emissions underlying electricity source building use type climate additionally new term entitled chp attributable reductions introduced quantify benefits simultaneous use thermal electric energy removing benefits achieved solely fuel switching generating electricity efficiently ghg emission benefits implementing internal combustion engine microturbines phosphoric acid fuel cell based chp systems evaluated optimization approach considering energy demands prototypical hospital office residential buildings varied climates explore effect electric ghg emissions rates ideal operation chp systems evaluated three scenarios high ghg emissions rates low ghg emissions rates current ghg emissions rate specific location analysis finds fuel cells achieve highest ghg emission reductions cases considered though exceptions common heuristics electric load following thermal load following optimal operating strategy specific conditions optimal chp capacity operating hours vary function building type climate ghg emissions rates grid electricity ghg emissions reductions high considering fuel cell prototypical hospital boulder colorado however chp attributable reductions less elsevier ltd rights reserved
background condition non coeliac gluten sensitivity ncgs clinically similar coeliac disease lack objective diagnostic criteria symptom relief gluten free diet followed gluten containing food challenge may confirm condition clinical settings aim describe results open bread challenge patients suspected ncgs compare results recently suggested cut offs symptom change material methods fifty six patients males self instituted gluten free diet negative coeliac disease diagnostics examined ncgs open bread challenge symptoms reported gastrointestinal symptom rating scale ibs version gsrs ibs visual analogue scale vas results retrospectively compared salerno monash cut offs symptom change results forty seven patients diagnosed ncgs total gsrs ibs score overall symptoms vas increased significantly ncgs non ncgs patients respectively total gsrs ibs challenge score overall symptoms vas significantly higher ncgs non ncgs patients respectively applying salerno monash cut offs would classified ncgs respectively according total gsrs ibs absolute agreement lowest clinician diagnosis salerno cut highest salerno monash cut offs conclusion clinician diagnosed ncgs proportion ncgs lower according salerno monash cut offs salerno cut starting point common definition symptom change
markov chain monte carlo mcmc methods proven powerful tool analyzing data complex structures however computer intensive nature typically require large number iterations complete scan full dataset iteration precludes use big data analysis article propose called bootstrap metropolis hastings bmh algorithm provides general framework tame powerful mcmc methods used big data analysis replace full data log likelihood monte carlo average log likelihoods calculated parallel multiple bootstrap samples bmh algorithm possesses embarrassingly parallel structure avoids repeated scans full dataset iterations thus feasible big data problems compared popular divide combine method bmh generally efficient asymptotically integrate whole data information single simulation run bmh algorithm flexible like metropolis hastings algorithm serve basic building block developing advanced mcmc algorithms feasible big data problems illustrated article tempering bmh algorithm viewed combination parallel tempering bmh algorithm bmh also used model selection optimization combining reversible jump mcmc simulated annealing respectively supplementary materials article available online
ceritinib second generation selective potent oral anaplastic lymphoma kinase alk inhibitor approved alk positive advanced non small cell lung cancer previously treated crizotinib population pharmacokinetic analysis performed describe ceritinib used evaluate covariate effects systemic exposure label dose orally daily ceritinib concentration time data clinical studies described compartment model delayed first order absorption time dependent elimination apparent clearance steady state determined increase body weight albumin decrease increase alanine aminotransferase japanese ethnicity appeared significantly influence apparent fractional turnover rate inhibited metabolic enzyme dose adjustment necessary patients lower body weight preexisting mild hepatic impairment ceritinib steady state exposure auc increased prediction interval non japanese asians japanese patients compared white patients covariates including sex age baseline eastern cooperative oncology group performance status baseline total bilirubin baseline estimated glomerular filtration rate prior crizotinib treatment concomitant use proton pump inhibitors statistically significant effect ceritinib parameters conclusion nonlinear ceritinib described using population based approach patients alk positive tumors none covariates assessed study considered clinically relevant therefore warrant dose adjustment
micro controllers arduino widely used kinds makers worldwide popularity driven arduino simplicity use large number sensors libraries available extend basic capabilities controllers last decade witnessed surge software engineering solutions internet things several cases solutions require computational resources advanced simple resource limited micro controllers surprisingly spite basic ingredients complex hardware software systems seem simple flexible way extend basic capabilities micro controllers coordinate inter connected micro controllers internet things indeed new capabilities added per application basis interactions mainly limited bespoke point point protocols target hardware rather services provided hardware paper present arduino service interface programming asip model new model addresses issues providing service abstraction easily add new capabilities micro controllers providing support networked boards using range strategies including socket connections bridging devices mot based publish subscribe messaging discovery services etc provide open source implementation code running arduino boards client libraries java python racket erlang show asip enables rapid development non trivial applications coordination input output distributed boards implementation line following algorithm remote robot assess performance asip several ways quantitative qualitative elsevier rights reserved
variety research areas weighted bag vectors histogram widely used descriptors complex objects expressed discrete distributions clustering pursues minimum total within cluster variation set discrete distributions subject kantorovich wasserstein metric clustering severe scalability issue bottleneck computation centroid distribution called wasserstein barycenter minimizes sum squared distances cluster members paper develop modified bregman admm approach computing approximate discrete wasserstein barycenter large clusters case support points barycenters unknown low cardinality method achieves high accuracy empirically much reduced computational cost strengths weaknesses method alternatives examined experiments recommend scenarios respective usage moreover develop serial parallelized versions algorithm experimenting large scale data demonstrate computational efficiency new methods investigate convergence properties numerical stability clustering results obtained several datasets different domains highly competitive comparison widely used methods corresponding areas
multiple sclerosis causes demyelinating lesions white matter increased iron deposition subcortical gray matter myelin protons extremely short directly detected conventional clinical magnetic resonance imaging sequences iron deposition also reduces leading reduced signal clinical sequences study tested hypothesis inversion recovery ultra short echo time ute pulse sequence directly simultaneously image myelin iron deposition using clinical scanner technique first validated synthetic myelin phantom myelin powder feridex iron phantom followed studies cadaveric specimens healthy volunteers patients ute imaging synthetic myelin phantom showed excellent component signal decay two populations protons one residual water protons myelin protons ute imaging shows sensitivity wide range iron concentrations similar ute signal white matter brain healthy volunteers shows rapid signal decay short similar consistent values myelin protons synthetic myelin phantom ute imaging brain specimens patients showed multiple white matter lesions well areas high signal subcortical gray matter specimens corresponded position perl diaminobenzide staining results consistent increased iron deposition ute imaging simultaneously detects lesions myelin loss white matter iron deposition gray matter elsevier inc rights reserved
battery state charge soc important parameter battery capacity state indirectly estimated measurable variables voltage current temperature accurate estimation soc one key problems battery management system battery model based equivalent electrical circuits used describe battery dynamics model experimentally validated using laboratory test battery soc estimated real time means two methods luenberger observer kalman filter paper presents comparison two model based soc estimation algorithms
purpose worksite health promotion whp programs reduce occurrence cardiovascular disease risk factors state law encourage employers employer provided insurance companies offer comprehensive whp programs research examines state law authorizing whp programs design quantitative content analysis setting worksites workplaces subjects united states district columbia intervention state law effect authorizing whp programs measures frequency distribution states whp laws analysis determine content laws analysis coding identified policy elements centers disease control prevention worksite health scorecard hsc additional supportive whp strategies used strategies key words search laws authorizing whp programs select whp elements calculated number type whp elements state whp laws selected two case examples states comprehensive whp laws results twenty four states authorized onsite whp programs authorized whp employer provided insurance plans authorized seven states comprehensive whp strategy addressing hsc elements common hsc elements weight management tobacco cessation physical activity conclusion states laws encouraging adoption whp programs massachusetts maine implementing comprehensive whp laws studies evaluating health impact needed
field primary headaches cranial neuralgias experienced relatively brief period startling progress expansion knowledge allowed partial unraveling machinery involved occurrence attacks identification set mediators genes likely play role case migraine accumulated evidence recently led development first disease specific prophylactic drug cgrp antibodies cases drugs available indications different pain botulinum toxin antiepileptic drugs tested adapted protocols proving effective chronic migraine showing potential efficacy cranial pains cluster headache trigeminal neuralgia temporomandibular joint disorder notwithstanding undeniable scientific advances much research still needed fully understand effectively treat primary headaches cranial neuralgias open issues manifold spanning pathophysiology clinical aspects represent exciting challenges future research
adequate response global climate change low carbon economy development become worldwide concerned subject one energetically intensive industries construction industry key area promote decarbonization important path realize national strategic goals carbon reduction china paper focuses low carbon technology integration management analyzes existing research status green building low carbon buildings related evaluation indexes proposes evaluation system framework low carbon technology integration innovation perspective system management points evaluation low carbon technology innovation conducted smarter managing system resource input process control system comprehensive performance output furthermore based questionnaire survey exploratory factor analysis result selected indexes paper implements rough set method identify weight indexes found managers focus affordable input beginning stage management control middle period innovation instead output performance later stage indicates management control front stages essential later ones constructed evaluation framework system perspective properly reflect integrity multi level stakeholder structure technology integration low carbon projects could support decision maker considering complexity construction evaluation technology innovation performance multi level perspective combined methods adopted exploratory factor analysis rough set evaluation determine evaluation index weights could well reflect overall performance low carbon project evaluation selected indicators certain scientific practical effectiveness could provide references enterprise lct innovation management industry multi level technologies integration single technological adoption innovation satisfy economic transformation requirements modern construction industry development integration innovation management evaluation model needed sustainability evaluation construction practice development main scientific objective study taking consideration entire life cycle assessment various factors elsevier ltd rights reserved
background spinal cord stimulation improves microcirculatory blood flow relieves diabetic neuropathic ischaemic pain reduces amputation rate patients severe peripheral arterial occlusive disease aim evaluate whether transcutaneous oxygen tension tcpo measurements used specific prognostic parameter assessment suitability permanent device implantation prospective controlled study diabetic patients peripheral arterial occlusive disease methods sixty patients men women mean age years range submitted implantation spinal cord electrical generator severe peripheral vascular disease failed conservative surgical treatment clinical status classified fontaine stage iii main pathology diabetic vascular disease pedal tcpo assessed dorsum foot ankle toe pressure doppler measurements performed two weeks four weeks implantation results pain relief limb salvage achieved diabetic patients partial success pain relief limb salvage least months obtained patients method failed affected limbs amputated clinical improvement spinal cord stimulation success associated increases tcpo within first two weeks implantation temporary period limb salvage achieved significant increase tcpo within first two weeks testing period mmhg rest pain patients mmhg patients trophic lesions size trophic lesions mmhg unrelated stage disease initial tcpo value tcpo changes related presence adequate paraesthesias warmth painful area trial period systolic anklelbrachial blood pressure index toe pressure change stimulation conclusions two week testing period performed diabetic patients treated spinal cord stimulation peripheral arterial occlusive disease identify candidates permanent implantation diabetic patients significant increases tcpo clinical improvement test period considered permanent implantation merely patients pain relief tcpo changes could used predictive index therapy success considered terms cost effectiveness final decision permanent implantation
research question sport fandom acknowledged offering consumers opportunity differentially engage well create value network interaction enhancing social well social integration however recent research indicates sport fandom escalates escalates time calls examine intersection parenting sport fandom research focuses mothers fathers examines sport fandom intensifies declines consequence raising children research add understanding fandom identifying circumstances sport fandom bonding detaching experience parents role plays socialization consumer behavior research methods study adopts multi method interpretive qualitative approach using depth interviews online discussion forum sampling frame consists total parents using two stages research stage stage participants varying stages parenthood single mixed gender families results findings study develops typology escalating sport fandom parenthood differentiates fandom pertaining individual social identity data also reveal varying dichotomies excess moderation risk reward individual shared behaviors including customer customer interaction well perceptions allegiance disloyalty implications knowledge parenting sport fandom assist managers developing effective loyalty schemes marketing packages offer understanding temporal effect children fandom
zing finger protein zfp novel cys zinc finger transcription factor anti apoptotic role myocardial cells involved endothelial transforming growth factor beta tgf beta signal transduction pathway mothers decapentaplegic homolog smad binding partner aim present study determine involvement zfp tgf beta mediated cytoprotection chemical hypoxia induced apoptosis using cardiac myocytes hypoxia chemically induced myocardial cells exposure cobalt chloride cocl response hypoxia cell viability decreased whereas expression levels hypoxia inducible factor alpha zfp increased pretreatment tgf beta attenuated cocl induced cell apoptosis upregulated zfp protein expression however effects could suppressed inhibitor tgf beta type receptor smad phosphorylation furthermore suppression zfp expression rna interference reduced anti apoptotic effects tgf beta thus increased cocl induced apoptosis cell lymphoma bcl associated protein bcl ratio reactive oxygen species generation caspase activation also increased following zfp inactivation conclusion results indicate zfp component tgf beta smad signaling pathway involved protective effects tgf beta chemical hypoxia induced cell apoptosis inhibition mitochondrial apoptotic pathway
article reports chromic polymer responsive shape memory properties behavior shape memory polymers chromic materials employed strategy fabricate smart material represents new principle making chromic materials material made shape memory polyurethane tetraphenylethylene units covalently connected soft segments pcl material displays biocompatibility shape fixity almost shape recovery reversible mechanochromic solvatochromic thermochromic shape memory effect memory chromism represented reversible change emission intensity shows negative correlation shape fixity temperature existence solvent may explained soft segments molten dissolved solvent shape recovery switch open aie units free crystal binding migrate easily larger areas thus aie units particles far apart barrier rotation phenyl groups reduced lead reduction emission intensity appeared colors pale colors vice versa since switch fundamental structural character smps shape memory properties led chromism call memory chromic wiley periodicals inc polym sci part polym phys
background anxiety mood disorders shown relevant psychiatric comorbidities associated migraine influencing clinical course treatment response clinical outcomes limited information available specific anxiety depression symptoms related migraine symptoms based approach current trend mental health research may improve understanding migraine comorbidity purpose study analyze anxiety depression aspects related migraine symptom based approach methods studied patients general population completed self administered questionnaire assessing demographics headache features anxiety depression symptoms binary logistic regression analyses conducted test association four ratings gad anxiety phq depression scales subitems covariates migraine headache outcome results leading odd ratios observed individuals migraine relative without migraine anxiety related able stop control worrying daily basis trouble relaxing feeling nervous anxious edge daily basis worrying much different things although hallmark symptoms depression emotional hopelessness sadness highest scores found physical apetite fatigue poor sleep irritability significant increase migraine risk experienced days half days experienced nearly every day conclusions anxiety robustly associated increase migraine risk depression lack ability properly control worrying relax prominent issues migraine psychiatric comorbidity physical symptoms depression linked migraine emotional symptoms symptom based approach helps clarifying migraine comorbidity replicated studies
study aims reduce earthquake induced vibrations container crane structures using active vibration control vibration control using intelligent controllers fuzzy logic attracted attention structural control engineers last decade fuzzy logic handle uncertainties heuristic knowledge even nonlinearities effectively easily improved seismic control performance performed converting simply designed static gain real time variable dynamic gain self tuning mechanism several advantages self tuning fuzzy logic control algorithm used study furthermore aim increasing performance designed controller derivative integral controller independent fuzzy logic controller added architectural structure controller structure called self tuning fuzzy logic pid controller stflpidc study six degrees freedom nonlinear mathematical model container crane structure defined controller developed performance designed controller evaluated numerical simulations simulations ground motion kobe earthquake japan january used earthquake excitation time history displacements accelerations frequency responses uncontrolled controlled cases crane structure control force obtained performance designed controller compared classical fuzzy logic controller flc comparison stflpidc flc frequency time domain presented evaluate effect performance controllers simulations stflpidc show better seismic performance classical flc besides robustness stflpidc checked change rigidity parameters revealed using designed controller active vibration control system causes suppression earthquake induced vibration
certain situations syntactically valid incorrect data entered database result near immediate catastrophic financial losses organization examples include omitting zeros prices goods commerce sites financial fraud data directly entered databases bypassing application level financial checks dangerous data detected deviates substantially statistical properties existing data detection kind problem requires comparing individual data items large amount existing data database run time furthermore identification errors probabilistic rather deterministic nature research proposes part whole validation approach addressing dangerous data situation part whole validation addresses fundamental issues database management example integrity maintenance illustrative representative examples first defined analyzed architecture part whole validation presented implemented prototype illustrate feasibility research
expectation reward shaped observation actions expressions people one environment person apparent confidence likely reward action instance makes qualities evidence observed directly socially accessible strategy computationally distinguished associative learning methods rely direct observation use inference indirect evidence twenty three healthy human subjects isolated effects first hand experience people choices mediating effect confidence decision making neural correlates value within ventromedial prefrontal cortex vmpfc value derived first hand experience people choices regardless confidence indiscriminately represented across vmpfc however value computed agent choices weighted associated confidence represented specificity ventromedial area pattern corresponds shifts connectivity overlapping cognitive processes along posterior anterior vmpfc axis task behavior self reported self reliance decision making social contexts correlated tendency conform social contexts corresponded increased activation cortical regions previously shown respond social conflict proportion subsequent conformity campbell meiklejohn tendency self monitor predicted selectively enhanced response accordance others right temporoparietal junction rtpj findings anatomically decompose vmpfc value representations according computational requirements provide biological insight social transmission preference reassurance gained confidence others
predicting behavior geotextiles made polyesters polypropylene fibers described differential equations derived mechanical models thereby describe behavior geotextiles elastic limit elastic limit represents permissible load geotextile material may subjected exploitation without distorting structure elastic limit defined analyzing stress strain curve analyzed geotextiles nonwoven geotextile materials polyester polypropylene fibers surface mass used experimental material
work address stabilization optimization issues class linear systems terms pathwise state feedback impulsive control show pathwise state feedback impulsive mechanism universal asymptotically stabilizable system admits impulsive control law furthermore improve system performance solve min max problem optimizing impulsive paths via proper algorithm design numerical example illustrates efficiency proposed method
paper compares performance kwp grid residential solar photovoltaic power system using pvsyst simulation software household kunming yunnan province china monthly available solar energy missing energy array final reference yields performance ratio array capture system losses analyzed five solar tracking modes fixed tilted plane seasonal tilt adjustment horizontal axis tracking vertical axis tracking dual axis tracking although similar aspects across five systems minimum available solar energy kwh maximum missing energy kwh obtained using fixed tilted plane system tilt angle degrees azimuth angle degrees whereas maximum available solar energy kwh minimum missing energy kwh october obtained using dual axis tracking system average monthly performance ratio maximal fixed tilted plane system minimal dual axis tracking system hydrogen energy publications llc published elsevier ltd rights reserved
background parkinson disease presently conceptualized protein aggregation disease pathology involves enteric central nervous system possibly spreading one another via vagus nerves gastrointestinal dysfunction often precedes parallels motor symptoms enteric system vast diversity microorganisms may involved pathogenesis alterations enteric microbial taxonomic level dopa naive patients might also serve biomarker methods performed metagenomic shotgun analyses compared fecal microbiomes early stage dopa naive patients age matched controls results found increased verrucomicrobiaceae akkermansia muciniphila unclassified firmicutes whereas prevotellaceae prevotella copri erysipelotrichaceae eubacterium biforme markedly lowered samples observed differences could reliably separate control roc auc functional analyses metagenomes revealed differences microbiota metabolism involving beta glucuronate tryptophan metabolism abundances prophages plasmids differ controls total virus abundance decreased participants based analyses intake either mao inhibitor amantadine dopamine agonist summary relates patients overall influence taxa abundance microbial functions conclusions data revealed differences colonic microbiota microbiota metabolism patients controls unprecedented detail achievable sequencing findings point yet unappreciated aspect possibly involving intestinal barrier function immune function patients influence parkinsonian medication investigated future larger cohorts
note addresses parameterization issues nonlinear observer based fault detection systems composed residual generator residual evaluator threshold study consists two steps first step aid nonlinear factorization input output operator techniques prove stable residual generator parameterized cascade connection process kernel representation post filter represents parameter system second step based state space representation parameterized residual generators investigate called infinity classes observer based systems leads parameterization threshold settings classes systems associated characterization existence conditions
purpose purpose paper evaluate accuracy functionality selection basic android ios apps mobile devices designed generate bibliographic citations design methodology approach number inexpensive free apps installed several different tablets phones book citations mla apa format generated evaluated accuracy findings results show majority apps tested produced unacceptably inaccurate citations many limited functionality best apps tested easybib research limitations implications infinite combinations operating systems apps citation styles material types devices testing study limited uncomplicated apps likely appeal undergraduate students include sophisticated apps managing reference libraries study investigated well several android ios apps installed mobile devices functioned generate mla apa citations print books practical implications role mobile technology education continues grow librarians need remain aware solutions help students manage research librarians opportunity provide feedback developers reviewing rating apps originality value undergraduate students face challenges learning appropriately acknowledge materials consulted research writing librarians play important role helping students select appropriate tools make citing sources easier accurate
near field thermophotovoltaic nftpv devices received much attention lately alternative energy harvesting system whereby heated emitter exchanges super planckian thermal radiation photovoltaic cell generate electricity work describes use grating structure enhance power throughput nftpv devices increasing energy conversion efficiency ensuring large portion radiation entering cell band gap device contains high temperature tungsten grating radiates photons room temperature cell vacuum gap several tens nanometers scattering theory used along rigorous coupled wave analysis rcwa calculate radiation energy exchange grating emitter tpv cell parametric study performed varying grating depth period ridge width range fabricated using available fabrication technologies found power output increased improving efficiency selected grating emitter compared case flat tungsten emitter reasons enhancement found due enhanced energy transmission coefficient close band gap work shows possible way improving nftpv sheds light grating structures interact thermal radiation nanoscale
although well established rhythmically coordinating social partner increase cooperation yet unclear intentional coordination effects distinguish three dimensions along explanations might vary first pro social effects might require phase synchrony simply coordination second effects rhythmic movements cooperation might direct mediated intervening variable third pro social effects might occur proportion quality coordination occur threshold amount coordination occurred report experiment two follow ups sought identify classes models required account positive effects coordinated rhythmic movement cooperation across studies found evidence coordination synchrony pro social consequences long social nature task perceived effects intentional coordination direct mediated degree coordination predict degree cooperation fact inter personal coordination moving together time social context required pro social effects suggest future research use kind carefully controllable experimental task used continue develop explanations coordination affects pro social behaviors
domain information technologies certification exams widespread mechanism validation expertise specific domains knowledge comptia organization recognized ansi created respond demand certification information technology comptia security certification internationally recognized validation skills related computer security absence ontologies semantic markup learning objects domain certification exam context semantic web main motivation development proposal article presents proposal domain ontology network security certification exam developed reaching formal modeling protege subdomain firewalls
paper proposes low power low output ripple regulator radio frequency identification tags inner blocks regulator supplied elementary stages output rectifier proposed operational amplifier works class bias adaptive biasing form bandgap reference sampling voltage resistors used paper completely designed transistors culminate low power dissipation regulator output voltage output ripple value line regulation power supply rejection ratio regulator efficiency respectively power consumption calculated omega load simulation done help cadence software cmos technology operational frequency mhz layout proposed regulator
background headaches associated pituitary adenoma reported related structural characteristics endocrine factors tumour objectives objective study investigate prevalence clinical characteristics risk factors non functioning pituitary adenoma nfpa associated headaches chinese patients normal endocrine activity methods ninety seven patients nfpa normal endocrine laboratory results prospectively enrolled study relevant clinical demographic data collected examined appropriate statistical methods results pre operative prevalence tumour associated headaches patients migraine like headaches family history primary headache odds ratio higher tumour knosp grade identified risk factors occurrence nfpa associated headaches patient age sex visual disturbances optic chiasm compression tumour size tumour volume significantly associated nfpa associated headaches addition headache severity significantly correlated knosp grade sides headaches cavernous sinus invasion significantly concordant agreement kappa conclusions migraine like headaches common clinical manifestation patients nfpas family history primary headaches cavernous sinus invasion risk factors nfpa associated headaches
adverse relationship suboptimal fetal environments development adult diseases hypertension type diabetes cardiovascular disease reported numerous studies purpose study investigate strain difference offspring response maternal malnutrition pregnancy involvement renin angiotensin system ras development adult hypertension using cbl mice angiotensin ang type receptor associated protein transgenic atrap mice pregnant dams fed isocaloric diet containing either normal protein low protein protein birth weight significantly reduced offspring atrap offspring arterial blood pressure higher offspring groups contrast atrap offspring show increase blood pressure compared offspring renal angiotensin type receptor expression altered maternal malnutrition whereas angiotensin type receptor expression significantly decreased offspring conclusion findings suggest suboptimal intrauterine environment induces adult hypertension alteration expression ras components partly suppressed sustained atrap overexpression via attenuation receptor mediated pathological response soc hypertens american society hypertension rights reserved
artificial hair sensors ahs recently developed air force research laboratory afrl using carbon nanotube cnt deformation cnt air flow causes voltage current changes circuit used quantify dynamic pressure aerodynamic load along wing surface afrl done lot essential work design manufacturing measurement ahss work paper bridge current afrl work ahss feasible applications flight dynamics control gust alleviation highly flexible aircraft highly flexible vehicle modeled using strain based geometrically nonlinear beam formulation coupled finite state inflow aerodynamics feedback control algorithm rejection gust perturbations developed simplified linear quadratic regulator lqr controller implemented based state space representation linearized system ahs measurements used control input wing sectional aerodynamic loads defined control output designing feedback gain controller designed closed loop aeroelastic simulations performed evaluate performance different controllers force feedback compared traditional controller designs state feedback study feasibility ahss flight control assessed whole study facilitate building fly feel simulation environment autonomous vehicles
energy harvesting based tethered kites benefits exploiting higher wind speeds higher altitudes setup considered paper based pumping cycle generates energy winching high tether forces driving electrical generator flying crosswind winches stationary neutral position thus leaving net amount generated energy focus paper put flight control design implements accurate direction control towards target points allows flight eight pattern extended overview control system approach well details element flight controller presented control architecture motivated simple yet comprehensive model kite dynamics addition winch strategies based optimization scheme presented order demonstrate real world functionality presented algorithms flight data fully automated pumping cycle operation small scale prototype given setup based kite linked ground based electrical motor generator single line elsevier ltd rights reserved
study fifth order lowpass log domain butterworth filter appropriate bluetooth receiver designed signal flow graph approach filter realized using unique translinear integrator circuit bluetooth modes obtained without changing circuit configuration change mode filter needed change cutoff frequency filter electronically tuned adjusting external currents bluetooth receivers mhz khz cutoff frequencies respectively bjts grounded capacitors utilized achieve desired circuit lowpass log domain butterworth filter simulated using spice simulation program validated bjt idealized bjt models used obtain simulation results confirming theoretical analysis
despite substantial advances animal production efficiency last years feed still represents majority production costs negative impacts animal production environment must reduced implies reduction nutrient losses environment associated animal production feed efficiency mostly expressed feed conversion ratio fcr key indicator judge financial environmental performance farming system intensive rabbit breeding average farm fcr maternity fattening units european farms improved past years translates drop nitrogen phosphorus output approximately improvement attributed progress health control nutritional factors strategies management genetics optimize rabbit farm fcr reproducing stock well fattening unit must considered review summarizes impact different strategies optimize fcr intensive production conditions rabbits exclusively fed pelleted diet high performing reproduction stock results lower fcr maternity use diets nutrient levels optimize digestive health together appropriate feeding restriction weaning leads minimal losses large impact fcr different fiber requirements met increase dietary energy level especially finishing stage reduces fcr approximately points increase future possibilities genetic selection feed efficiency based improvements residual feed intake seems possible improve feed efficiency reducing feed intake without affecting weight gain genetic improvement would reduce feed input reducing costs output reducing environmental impacts average farm fcr similar pig breeding reached next decade rabbit meat production elsevier rights reserved
poly lactic acid pla biodegradable polymer high stiffness presenting limitation using actuator applications adding plasticizer one way solve problem enhance flexibility improve electromechanical properties pristine pla work pla films prepared via simple solvent casting method influences plasticizer type electric field strength electromechanical behavior pla films investigated melt rheometer bending measurement pla films filled dibutyl phthalate dbp storage modulus immediately increased towards steady state rapidly recovered original value without electric field respectively referred reversible system hand pla film tween processed highest delta due available amount polarized groups bending measurement dielectrophoresis forces plasticized pla films found increase increasing electric field deflections occurred towards anode side polarized groups generated negative charges dbp pla film exhibited greatest bending dielectrophoresis force thus biodegradable pla along dbp combine great potential towards actuator application elsevier ltd rights reserved
previous research identified number coordination processes enable people perform joint actions determines coordination processes joint action partners rely given situation present study tested whether varying shared visual information available actors trigger shift coordination processes pairs participants performed movement task required synchronously arrive target separate starting locations participants pair received auditory feedback time partner reached target held movement duration constant facilitate coordination received additional visual information movements switched fundamentally different coordination process exaggerating curvature movements communicate arrival time findings indicate availability shared perceptual information major factor determining individuals coordinate actions obtain joint outcomes authors published elsevier
alloxan material well known induce diabetes prior inducing prolonged diabetic state causes acute tubulointerstitial nephritis however precise primary target site mechanism nephrotoxicity remain unclear objective study evaluate morphological characteristics relevant acute renal toxicity following administration rats intravenously treated eight hours treatment aquaporin negative pump positive thick ascending limbs henle tal degenerated outer medulla tubular lesions progressed outer medulla cortex day treatment lesions reached peak proximal distal tubules also showed degeneration necrosis tubular regeneration seen tal immunohistochemically damaged tubular epithelium included slightly enlarged prohibitin positive granules expressed glut transporter ultrastructurally cytoplasmic mitochondrial swelling detected degenerated cells tal findings suggest initially causes degeneration tal induces mitochondrial cellular damage tubular epithelium without involving glut
renewable energy projects korea two avenues provide subsidies increase financial viability feed tariffs fits offer cost based prices renewable electricity compete conventional energy producers clean development mechanism cdm issues certified emission reduction cer credits generate additional revenues enhancing renewable projects return investment study investigated subsidies impact financial returns korea cdm projects investment analysis performed four cases including solar hydropower wind landfill gas projects revenues electricity sales fits cers compared using financial indicators measure relative contributions profitability results indicate cdm partial towards large scale projects high emission reductions moreover conflicts fit schemes deter small scale capital intensive projects pursuing registration analysis highlights cdm bias particular project types part due impartiality towards carbon credit prices also reveals korea key benefactor cdm susceptible biases demonstrated disproportionate distribution issued cers improving incentives bundled small scale projects cer price differentiation excluding domestic subsidies additionality testing proposed possible reforms
fecal microbial transplantation fmt established successful treatment modality recurrent clostridium difficile infection cdi safety profile potential therapeutic advantages fmt diseases associated dysbiosis immune dysfunction led many publications mainly case series many studies reviews published use fmt inflammatory bowel disease ibd potential use disease conditions thoroughly reviewed aim review investigate evidence surrounding use fmt conditions ibd cdi pubmed search performed using terms fecal microbiota transplantation fmt bacteriotherapy total articles describing use fmt variety intra extraintestinal disease conditions including gastrointestinal hematologic neurologic metabolic infectious autoimmune disorders included review demonstrated positive results studies included case reports case series controlled trials cohort studies findings studies demonstrate fmt particularly conditions associated gastrointestinal dysbiosis shows promise provide another effective tool therapeutic armament practicing physician fmt found possibly effective various diseases mostly associated enteric dysbiosis immune dysfunction randomized clinical studies large populations performed explore effectiveness therapy basic research studies designed gain understanding mechanisms impact disorders
background recent many studies found abnormal neurometabolites acute bipolar disorder however limited studies detect neurometabolites remitted comparison acute remitted conductive understand outcome neurometabolites study sought investigate differences neurometabolites remitted depressed patients using proton magnetic resonance spectroscopy mrs methods three subject groups enrolled remitted patients depressed patients healthy controls subjects underwent mrs measure acetylaspartate naa choline cho myo inositol creatine several bilateral areas potentially involved prefrontal whiter matter pwm thalamus putamen neurometabolite ratios compared among three groups correlations abnormal neurometabolite ratios clinical data computed results lower bilateral pwm naa ratios found depressed patients remitted patients healthy controls differences found remitted patients controls depressed patients left pwm naa ratios showed negative correlation age onset right pwm naa ratios showed positive correlation duration illness conclusions findings suggest abnormal neurometabolites prefrontal lobe whiter may occur depressed remitted may resemble healthy subjects terms neurometabolites addition abnormal neurometabolites prefrontal lobe whiter may correlate age onset illness length
staircase fractional part functions basic examples real functions applied several parts mathematics analysis number theory formulas primes computer programming floor ceiling functions provided significant number programming languages basic uses various programming tasks paper view staircase fractional part functions classical example non continuous real functions introduce basic properties present interesting constructions concerning explore intriguing interpretations functions throughout paper use functions order explain basic concepts first calculus course domain definition discontinuity oddness functions also explain detail researching properties functions one draw graph crucial part process understanding nature paper present subjects first year student exact sciences may encounter try clarify subjects show ideas important understanding non continuous functions part studying analysis general
background women health key factor affecting health whole population tackling inequality determinants health recognized main path toward reducing inequality health outcomes study aimed analyze provincial inequality determinants women health health care iran methods using moss model comprehensive framework determinants women health including geopolitical environment culture norms sanctions women roles reproduction production health related mediators health outcome categories chose indicators afterward using data sources including iranian multiple indicators demographics health survey national organization civil registration statistics centre iran analyzed provincial inequality indicators iran gini coefficient lorenz curve used measuring inequality results gini coefficients calculated follows life satisfaction level literate women women proper knowledge hiv aids prevention unemployed women women without income women use least one type mass media women used computer internet women received pregnancy care skill birth attendant sba women delivered help sba women currently smoke cigarettes women currently consume hookah women least one chronic disease women deaths respectively conclusions found large provincial disparities determinants women health iran determinants lifestyle health behavior health knowledge health care services availability considered health policymakers addressing inequality women health provincial level
energy use internal combustion engine passenger vehicles contributes directly emissions fuel consumption well producing number air pollutants optimizing vehicle velocity utilising upcoming road information opportunity minimize vehicle energy use without requiring mechanical design changes dynamic programming capable optimization task shown simulation produce fuel savings average compared real driving data however paper also applied real time raspberry low cost miniature computer situ vehicle test drive undertaken driver feedback provided dynamic programming algorithm results compared simulated intelligent cruise control system follow algorithm results precisely reduction fuel loss time reported compared test driver
multiple sclerosis putative autoimmune disease central nervous system cns autoreactive immune cells recognizing myelin antigens lead demyelination axonal injury mechanisms relevant pathogenesis fully elucidated particularly underlying initiation immune system dysfunction example known reactivity cns components generated within peripheral immune system review propose significant contribution immunoregulatory events may derive cell cell communication system involving production secretion transfer extracellular vesicles known exosomes herein discuss detail biogenesis roles cell surface generated vesicles standpoint receptors cargo microrna well known exosomes cross blood brain barrier thus may contribute spread brain antigens periphery understanding exosome dependent mechanisms provide novel angle analysis pathogenesis disease finally launch idea exosomes contents may serve biomarkers published elsevier
doped graphene based materials recently recognized promising adsorbents capture understanding adsorption mechanism atomic level still limited herein local structures promotion mechanism capture doped graphene investigated combining density functional theory initio thermodynamics single vacancy defected graphene involving dual doping found superior adsorbent capture mild conditions degrees atm enhanced adsorption performance ascribed charge delivery channel along path leading extra charge transfer graphene worth mentioning extra charge transfer stimulated unique hybridization pyridine enhanced dual doped graphene possible mechanism proposed explain high adsorption performance dual doped graphene offers insights design new graphene based adsorbents elsevier rights reserved
paper presents shunt active power filter apf division summation sigma digital control based three phase three wire inverter configuration apf shapes source current introducing one degree freedom compensate load harmonic currents adopted sigma digital control approach accommodate filter inductance variation reducing core size significantly derive control laws directly average power method adopted paper determining fundamental current source side readily implemented without complex calculation frame transformation extra filter design implementation inductances corresponding various inductor currents estimated startup stored microcontroller scheduling loop gain cycle cycle ensure system stability measured results kva three phase apf confirmed analysis discussion apf
objectives assess effectiveness week cognitive behavioral therapy cbt group based enhancement home visiting address stress prevent depression compared home visiting usual low income mothers young children methods conducted randomized controlled trial low income mothers young children assess effectiveness week cognitive behavioral group based enhancement healthy families america parents teachers home visiting cbt address stress prevent depression compared home visiting usual booster sessions cbt group offered months participants completed measures coping stress depression three points baseline prior randomization post intervention months post intervention parent child interaction also measured months results intent treat analyses found improved coping reduced stress depression post intervention impacts outcomes attenuated months positive impacts observed selected aspects mothers interactions children maternal characteristics baseline associated participation intervention post intervention month outcomes mothers lower levels stress fewer children likely attend intervention sessions mothers lower levels stress favorable post intervention outcomes conclusions cbt group based enhancement home visiting improved maternal coping reduced stress depression immediately post intervention months suggesting work needed sustain positive gains low income mothers young children
novel bias scheme realizing low voltage second order translinear loops introduced paper provided design examples include current geometric mean squarer divider multiplier divider cells performed comparison shows derived analog signal processing blocks offer reduced circuit complexity improved performance compared corresponding already published counterparts
gabriel abend discusses interest sociology morality main ideas book moral background inquiry history business ethics abend according abend business ethics discipline growing popularity business schools deals tension making money ethical preconditions enable moral life moral background abend states studying moralities moral action social sciences usually viewed lens first one behavioral level second one normative level moral immoral behavior norms respectively taken together constitute first order morality abend also points moral background suggested third level second order morality underlies supports first order morality six dimensions include reasons first level morality support existing concepts repertoire subject moral evaluation proper moral methods objectiveness morality metaphysical conceptions dimensions society level organization conceptual repertoire speaking moralities different languages dimensions individual level organization objectivity relativity first order morality abend identifies two types moral background describes christian merchant standards practice christian merchant type characterized ethics developing certain features character moral objectivism standards practice ethics sustains moral relativism emphasizes moral actions particular attention motives standards practice type found way business schools curricula business ethics discipline believes morality taught using case studies approach maintaining principles corporate social responsibility negative effects society economy long corporations suggest ethics pays act morally make profit risk without payoff stop acting morally fact causes questions surface corporate social responsibility ethical behavior business ultimately values place morality society large
hadoop distributed file system hdfs mapreduce model become popular technologies large scale data organization analysis existing model data organization processing hadoop using hdfs mapreduce ideally tailored search data parallel applications need data dependency neighboring adjacent data however many scientific applications image mining data mining knowledge data mining satellite image processing dependent adjacent data processing analysis paper identify requirements overlapped data organization propose two phase extension hdfs mapreduce programming model called xhami address extended interfaces presented apis implemented context image processing application domain demonstrated effectiveness xhami case studies image processing functions along results although xhami little overhead data storage input output operations greatly enhances system performance simplifies application development process proposed system xhami works without changes existing mapreduce models utilized many applications requirement overlapped data copyright john wiley sons ltd
article uses data analyze parental leave policies twenty one european countries influence men behavior examines entitlement characteristics nontransferability duration payment compulsory period policies assess effect proportion leave men use total parental leave country findings suggest large majority men take nontransferable highly paid leave small minority take types provide basis developing parental leave equality index plei plei ranks countries degree parental leave policies reinforce diminish gendered division labor results indicate although iceland parental leave policies advance gender equity country equal nontransferable well paid leave parent policy arrangement would precondition men women equal participation childcare
project scheduling important part construction project planning resource leveling process used within project scheduling reduce fluctuations resource usage period project implementation fluctuations frequently create untenable requirement regularly hiring firing temporary staff resources meet short term project needs construction project decision makers currently rely experience based methods manage fluctuations however methods lack consistency may result unnecessary wastage resources costly schedule overruns research introduces novel optimization model called fuzzy clustering chaotic based differential evolution solving multiple resources leveling multiple projects scheduling problem fcde mrlmp novel fuzzy clustering chaotic based differential evolution fcde algorithm integrates fuzzy means clustering chaotic techniques original differential evolution algorithm handle complex optimization problems chaotic technique prevents optimization algorithm converging prematurely fuzzy means clustering technique acts several multi parent crossover operators order utilize population information efficiently enhance convergence efficiency experiments run indicate proposed model obtains optimal results reliably efficiently benchmark algorithms considered proposed optimization model promising alternative approach assist project managers handle resource leveling project scheduling problems effectively faculty engineering alexandria university production hosting elsevier
objective identify effective mind body exercise programs provide clinicians patients updated high quality recommendations concerning non traditional land based exercises knee osteoarthritis methods systematic search adapted selection criteria included comparative controlled trials mind body exercise programs patients knee osteoarthritis panel experts reached consensus recommendations using delphi survey hierarchical alphabetical grading system used based statistical significance clinical importance improvement results four high quality studies identified demonstrated various mind body exercise programs promising improving management knee osteoarthritis hatha yoga demonstrated significant improvement pain relief grade physical function grade tai chi qigong demonstrated significant improvement quality life grade pain relief grade physical function grade sun style tai chi gave significant improvement pain relief grade physical function grade conclusion mind body exercises promising approaches reduce pain well improve physical function quality life individuals knee osteoarthritis
previous work shows children view group membership psychological traits essentialist terms perceiving biologically determined stable across time extent might individuals view mental states beliefs similarly given beliefs often based experience change across time one hypothesis beliefs whole elicit essentialism alternative hypothesis however beliefs may perceived inherited stable time characteristics associated essentialism three studies examined two aspects psychological essentialism regarding three different types beliefs religious beliefs factual beliefs opinions year old children adults asking whether beliefs seen biologically based stable across time children adults distinguished among belief types considering biology opinions perceived rooted biology beliefs contrast fewer consistent differences emerged children adults considered stability example children adults perceived opinions factual beliefs equally changeable finally although children typically perceived beliefs rooted biology adults specific patterns across belief types perceiving opinions rooted biology religious beliefs remained relatively stable across age groups thus development social learning may play larger role perceptions biological component essentialism judgments particular beliefs discuss implications literatures essentialism religious cognition social cognitive development elsevier inc rights reserved
important factor governs solar energy transformation electrical chemical energy using nanoparticles based devices spatial location traps limiting electron transport evidences presented indicating electron diffusion strongly influenced nanoparticle boundaries whose characteristics depend particles preparation present work studied role hydrated excess proton structures formation anatase nanoparticles boundaries samples prepared ticl hydrolysis low temperature strong acidic conditions samples constituted anatase nanocrystals mainly amorphous titania studied mas nmr hrtem results indicate hydrated excess proton species generated solvation bridging hydroxyls protons highly defective anatase amorphous titania chains favor chains bonding anatase nanoparticles condensation nanoparticles surface chains bonding facilitates anatase particles aggregation producing oriented self assemblings preparation conditions determine strong condensation amorphous titania chains favor anatase transformation rutile elsevier rights reserved
esterase inhibitor berinert generally used treat severe attack hereditary angioedema describe case patient presented severe angioedema induced angiotensin converting enzyme inhibitors aceis endangering life could successfully treated medicine
leed leadership energy environmental design rating system rates green buildings lca life cycle assessment tool evaluate environmental impacts building materials aim paper demonstrate importance integrating lca leed enhance rating system leed gold building presented research centennial college progress campus located toronto canada using athena impact estimator version conduct lca study analyses different building envelope solutions building materials affect results environmental assessment whole building building life cycle years environmental impact assessment leed buildings discussed research topics suggested example develop specific lca software tools integrate lca analysis green building rating system authors published elsevier ltd open access article license
nsw department primary industries delivered watersmart farms project australian government water future initiative project provided irrigation management training infrastructure upgrade grants licensed river potable water irrigators peri urban areas sydney basin securing megalitres water savings preventing export nitrogen phosphorus annually greenhouse vegetable producers region mostly culturally linguistically diverse communities enterprises small tight cash flows uncertain land tenure due potential rezoning investing expensive water efficient infrastructure disinfection filtration systems presented major barrier technology uptake address barriers extension team decided two pronged approach utilised demonstration farms showcasing basic low cost technology rainwater harvesting tanks high tech high cost recycling systems ozone copper ionisation ultra filtration systems concurrently services independent auditors engaged assess water savings potential options growers demonstration sites assisted increasing uptake recycling projects potable water savings per annum per site realised along significant reductions nitrogen phosphorus export catchment area financial analysis hydroponic greenhouse vegetable recycling project sites shown payback period two years overall project provided valuable data lessons help developing water management strategies long term water security river health peri urban landscapes
background iron plays essential role balancing various metabolism body also involved synthesis several neurotransmitters nutritional iron deficiency one widespread worldwide poses great health challenge due consequences entails objectives aim research study explore percentage psychiatric patients deficiency iron addition study investigates efficacy iron administered oral treatment psychiatric symptomatology among iron deficient patients research study utilized martial biological results involved observation level iron deficiency among outpatients local psychiatrist assessor period january december methods patients women men age participants ranged years average age years exclusion criterion patient refusal inability take prescribed iron assessment test considered transferrin saturation coefficient tsc serum ferritin level single method utilized various laboratories analyse blood samples determine whether deficiency iron patients blood ferritin levels tsc patients subsequently given exclusively oral iron treatment prescribed supplement simultaneously psychotropic treatment daily administered dose elemental iron varied day results half women subjects men subjects certainly deficiency iron blood ferritin level tsc remaining patients tsc unknown measured results indicated iron deficiency patients suffering mostly mood behavioural disorders patients suffering mostly anxiety disorders patients suffering mostly sleep disorders patients suffering mostly delusions persecution patients suffering mostly burn evidence regression remission psychiatric symptoms responsive patients whereas remaining patients considered non responsive responsive patient category participants treated iron received iron supplemented initial psychotropic treatment fully effective patients treated iron prescribed psychotropic drugs simultaneously iron treatment seems bring reduction particularly mono aminergic neurotransmitter synthesis promoting action hyperemotivity anxiety irritability aggressiveness sadness anhedonia apathy asthenia sleep disorders dysautonomia symptoms eating disorders restless leg syndrome cognitive performance likelihood resorting psychiatric admission daily elemental iron dose intake day deficient patients appears likely enhance effects psychotropic drugs even act actual antidepressant many patients received prescription iron antidepressants showed side effects related antidepressants small number required psychiatric hospitalization patients considered unresponsive iron therapy left study assessed study timeframe ended still iron deficiency continuously take medication suffered somatic diseases explains resistance treat low iron level nutritional imbalance digestive urinary gynecological iatrogenic diseases sleep apnea conclusion clinical observation two years local psychiatrist clinic revealed patients iron deficiency although low iron level explain physical psychiatric symptoms patients useful note half iron deficient patients responded favorably oral treatment iron result leads investigation level iron psychiatric patients reconsider iron range placed laboratories addition crucial eliminate possibility iron deficiency psychiatric patients research studies needed set specific detailed criteria determine range iron deficiency order support findings study optimize care given patients suffering various disorders psychiatric syndromes encephale paris
study describes analysis design improved recycling folded cascode using new input path positive feedback simultaneously increases transconductance considerably proposed amplifier bias circuits cmfb circuit simulated tsmc hspice circuit simulator according simulation results proposed circuit shows mhz gain gbw power dissipation respectively demonstrates gain enhancement mhz gbw improvement comparison recycling folded cascode capacitor load power dissipation finally corners monte carlo simulations performed verify robustness proposed circuit versus process temperature supply voltage device dimension mismatch variations
research learning analytics educational data mining recently become prominent fields computer science education scholars field emphasize student learning student data analytics however also important focus teaching analytics teacher preparation key roles student learning especially learning environments nonverbal communication strategies play important role successful interpersonal communication teachers students order assist novice practicing teachers exhibiting open affirmative nonverbal cues classrooms designed multimodal teaching platform provisions online feedback used interactive teaching rehearsal software teachlive basic research environment teachlive employs digital puppetry paradigm core technology individuals walk virtual environment interact virtual students displayed large screen practice classroom management pedagogy content delivery skills teaching plan teachlive environment designed experiment evaluate impact online nonverbal feedback application experiment different types multimodal data collected two experimental settings data include talk time nonverbal behaviors virtual students captured log files talk time full body tracking data participant video recording virtual classroom participant student teachers participated minute experiment settings participants provided teaching plans taught participants took part experimental settings order balanced experiment design half participants received nonverbal online feedback first session half received feedback second session visual indication used feedback time participant exhibited closed defensive posture based recorded full body tracking data observed received feedback first session demonstrated significant number open postures session containing feedback however post questionnaire information indicated participants mindful body postures teaching participated study
influence acuteness model angle direction printing investigated different three dimensional printers understand fidelity printing polyjet printer two fused deposition modeling printers used present study computer aided design cad models designed form triangular prism height varying angles degrees degrees degrees degrees degrees degrees cad designs additive manufacturing models printed three different directions three printers investigate global fidelity printers height surface outlines model cross sections measured fidelity models increasingly acute angles accurately reproduced printed surface outlines model cross sections different direction printing device printing technology printing direction need considered accurate reproduction acute angles fine structures medical models necessity
pregnant women affected substance use often encounter barriers treatment including housing insecurity poverty mental health issues social stigma access health care providers may lack resources needed provide quality care clinicians offering prenatal care women substance use disorder encouraged support family centered multidisciplinary care women infants focusing harm reduction collaboration providers maternity care substance abuse treatment case management family primary care pediatric developmental care improve outcomes pregnancy early years parenting
system identification problems impose nonnegativity constraints parameters estimated due inherent physical characteristics unknown system nonnegative least mean square nnlms algorithm variants allow one address problem online manner nonnegative least mean fourth nnlmf algorithm recently proposed improve performance algorithms cases measurement noise gaussian paper provides first theoretical analysis stochastic behavior nnlmf algorithm stationary gaussian inputs slow learning simulation results illustrate accuracy proposed analysis elsevier rights reserved
use software effectively efficiently chemical pharmaceutical life science industries one central questions process optimization paper shows five examples chemical engineering various programs connect first principle process simulator existing interfaces also shows functionality process simulator enhanced application programming interface api objects used beyond boundaries flow sheeting program chemcad
understanding intent relevance surrounding agents video essential task many applications robotics computer vision modeling evaluation contextual spatio temporal situation awareness particularly important domain intelligent vehicles robot required smoothly navigate complex environment also interacting humans paper address issues studying task road object importance ranking video first human centric object importance annotations employed order analyze relevance variety multi modal cues importance prediction task deep convolutional neural network model used capturing video based contextual spatial temporal cues scene type driving task object properties related intent second proposed importance annotations used producing novel analysis error types image based object detectors specifically demonstrate cost sensitive training informed object importance annotations results improved detection performance objects higher importance insight essential application navigation mistakes safety critical quality automation human robot interaction key
concept sustainability defined first time brudland report published united nations world commission environment development placed center several studies practices adaptation environment energy policies supporting economic development threatening natural life international community makes states establishments institutions business world non governmental organizations stakeholders force act way eco friendly smart buildings result sustainable environment policies construction sector widely responsible consumption natural resources environment pollution sustainable constructions called smart buildings green buildings tech buildings control automation systems kind building design stakeholders architects engineers landscape architects product manufacturers energy consultants project managers building users local administrators working together identification potential threats opportunities following technologies selection appropriate technological capabilities company industry acquisition technologies internal external companies usage required strategic management technology firms make investments research development acts construction industry future world using strategic technology management make power sustainable compete global market able find place market authors published elsevier ltd
mindfulness parenting relationship proposed help parents children better regulate stress though yet shown physiological level study tested relations maternal mindfulness parenting mothers infants hypothalamic pituitary adrenal hpa axis activity dyadic stressor months later participants mother infant dyads larger longitudinal study months postpartum mothers completed self report measures general dispositional mindfulness parenting specific mindfulness well stressful life events months postpartum mother infant dyads completed still face task four saliva samples collected dyad member cortisol assay index hpa axis response hierarchical linear modeling cortisol trajectories revealed main effect maternal parenting specific mindfulness mindful parenting general dispositional mindfulness mothers cortisol mothers higher mindful parenting showed steeper cortisol recovery slopes addition maternal mindful parenting moderated effect life stress later mother infant cortisol context high life stress maternal mindful parenting predicted lower infant cortisol levels extended maternal cortisol elevations implications biobehavioral model mindful parenting discussed
differentiated thyroid cancer common form thyroid cancer prognosis favourable cases suppression thyroid stimulating hormone tsh supra physiological thyroid hormone replacement mainstay long term management years however evidence beneficial outcome tsh suppression conflicting intervention must balanced adverse effects particularly affecting cardiovascular system skeleton discuss role tsh suppression long term management differentiated thyroid cancer context risk stratification disease recurrence latest clinical guidelines royal college radiologists published elsevier ltd rights reserved
study investigates ignition characteristics pulverised coal biomass firing use visual drop tube furnace vdtf high speed imaging technique three coals anthracite bituminous coal lignite four biomasses pine eucalyptus olive residue miscanthus various biomass coal mixtures tested coal biomass mixture distinct flame established within vdtf continuous feeding fuel environment air furnace teniperature degrees observe ignition point phantom high speed camera used capture videos fuel combustion frames per second fps technique developed using matiab image analysis tool automate ignition point detection results image processing used statistically analyse determine changes ignition behaviour different fuels firing ratios results obtained tested coals shown distance ignition increases coal volatile matter content decreases whereas opposite trend found biomass fuels addition biomass anthracite significantly reduces distance ignition much less pronounced effect ignition found biomass fired bituminous coal lignite synergistic effect ignition biomass anthracite mixture mainly attributed high volatile content potential effects catalysis alkali metals present biomass results study shown vdtf testing coupled image analysis technique allows effective simple method characterising ignition behaviours pulverised coal biomass mixtures authors published elsevier
combined two staged analytical hierarchy process ahp proposed respect compatibility selection textile architecture specifically examined ability support decision determination appropriate textile structures prior sensor integration textile structure selection methodology sensor integration implemented interviewing experts fields textiles electronics hence constructed two staged methodology including experimental study ahp respect different textile structures including transmission lines containing different conductive yarn types three different weave types manufactured via weaving technology first stage experimental part methodology second stage alternatives based experimental study evaluated using ahp comparisons made using priority scales assigned expert team synthesized get aggregated global ratings conclusion appropriate textile structures based weaving manufacturing technology sensor integration chosen using ahp technique ranking alternatives
objectives evaluate inhibition indirubin flss migration invasion activation proliferation flss methods levels cultural supernatants measured elisa fls migration invasion vitro measured boyden chamber method scratch assay signal transduction protein expression measured western blot fls proliferation detected edu incorporation actin measured immunofluorescence staining results found indirubin reduced migration invasion inflammation proliferation flss addition demonstrated indirubin inhibited lamellipodium formation cell migration gain insight molecular mechanisms evaluated effect indirubin pak mapk activation results indicated indirubin inhibited activity pak mapk conclusions observations suggest indirubin may protective joint destruction regulating synoviocyte migration invasion activation proliferation
payment systems healthcare system rewarded physicians services attempted control healthcare spending rewards penalties based upon projected goals future spending incorporation quality goals alternatives fee service introduced replace previous system rewards penalties describe history healthcare payment system focusing medicare efforts control spending sustainable growth rate describe latest evolution payment system emphasizes quality measurement alternative payment models conclude suggestions influence physician behavior education payment reform behavior aligns alternative care models control spending future
present paper proposes fuzzy neural network fnn based modelling identification structural parameters uncertain multi storey shear buildings method developed identify uncertain structural mass stiffness damping matrices dynamic responses structure without optimization processes generally used solve inverse vibration problems uncertainty taken term fuzzy numbers governing equations motion first solved classical method get responses consecutive stories governing equations motion modified based relative responses consecutive stories way new set equations implemented cluster fnns model starts solving nth floor fnn modelling estimate structural parameters subsequently series fnn models used estimate parameters storey first storey one may note single layer fnns used training cluster fnn converged weights give uncertain structural parameters initial weights fnn architecture taken design parameters uncertain fuzzy form order validate present model various example problems different multi storey shear structures considered related results incorporated term tables graphs comparisons theoretical identified results carried found good agreement
non suicidal self injury nssi immediate deliberate destruction one body tissue without suicidal intent purposes socially accepted critical concern youth schools despite significant scholarly advances increasing clinical awareness nssi many school mental health professionals mhps continue report feeling ill equipped support students self injure emphasize need formal education nssi management schools thus first part article summarizes current nssi research prevalence age onset gender differences functions risk factors associations suicide emerging review second part offers research informed recommendations mhps managing nssi schools including guidelines identifying students elevated risk self injury developing protocol school personnel initial response student self injury first level assessment nssi managing critical issues related nssi contagion online activity
neck surgery study presents review nanotechnology regenerative therapeutics focus applications implications plastic surgery british association plastic reconstructive aesthetic surgeons published elsevier ltd rights reserved rapid ascent nanotechnology regenerative therapeutics applied medicine surgery seen exponential rise scale research generated field evidenced sheer volume papers dedicated nanotechnology also large number new journals dedicated nanotechnology regenerative therapeutics specifically medicine surgery aspects nanotechnology already brought benefits areas include advanced drug delivery platforms molecular imaging materials engineering surgical implants particular areas interest include nerve regeneration burns wound care artificial skin nanoelectronic sensors head
complex software development projects rely contribution teams developers required collaborate coordinate efforts productivity development teams size related produced output important consideration project schedule management well cost estimation majority studies empirical software engineering suggest due coordination overhead teams collaborating developers become less productive grow size phenomenon commonly paraphrased brooks law software project management states adding manpower software project makes later outside software engineering non additive scaling productivity teams often referred ringelmann effect studied extensively social psychology organizational theory conversely recent study suggested open source software oss projects productivity developers increases team grows size attributing collective synergetic effects surprising finding linked aristotelian quote whole sum parts using data set oss projects commits contributed developers article provide large scale analysis relation size productivity software development teams findings confirm negative relation team size productivity previously suggested empirical software engineering research thus providing quantitative evidence presence strong ringelmann effect using fine grained data association developers source code files investigate possible explanations observed relations team size productivity particular take network perspective developer code associations software development teams show magnitude decrease productivity likely related growth dynamics editing networks interpreted first order approximation coordination requirements
several cases symptomatic hemicrania continua reported year old man suffering migraine without aura presented four month history new headache fulfilling ichd beta clinical criteria onset strictly related use transdermal nitroglycerine patch tnp agreement cardiologist tnp discontinued headache promptly disappeared symptoms reappeared within hours nitroglycerine reintroduction permanent discontinuation tnp headache disappeared one year follow best knowledge first report occurrence like headache related tnp
hyperalgesia increased pain sensitivity suggested contribute increased prevalence clinical pain parkinson disease experimental research equivocal mechanisms poorly understood conducted meta analysis studies comparing patients healthy controls hcs response experimental pain stimuli articles acquired systematic searches major databases inception twenty six studies met inclusion criteria comprising participants hcs random effects meta analysis standardized mean differences smd revealed lower pain threshold indicating hyperalgesia patients unmedicated states smd attenuated dopamine medicated states smd unaffected age duration severity analysis studies employing suprathreshold stimulation paradigms indicated greater pain patients failing reach significance smd findings support existence hyperalgesia could contribute onset intensity clinical pain implicate dopamine deficiency potential underlying mechanism may present opportunities development novel analgesic strategies elsevier rights reserved
background modifiable cardiovascular risk factors elevate risk subsequent depression older adults effect onset age incident depression unclear methods participants male medical students without diagnosis depression matriculated followed cox proportional hazards models used assess associations vascular risk factor burden diabetes hypertension hyperlipidemia smoking status overweight obese status onset incident depression adjustment covariates race enrollment wave baseline age physical activity heavy alcohol use results analysis included person years follow among participants depression free age vascular risk factor burden age hazard ratio confidence interval associated incident depression risk age magnitude vascular risk factor burden age depression risk age comparable effect additional years age diabetes hypertension hyperlipidemia age associated incident depression risk age men diagnosed diabetes age times risk incident depression age limitations findings restricted male former medical students may affect study generalizability conclusions results support vascular depression hypothesis depression screening older adults vascular risk factor burden may provide avenue prevention late onset depression
growing energy demands environmental degradation uncontrolled exploitation fossil fuels compelled world look alternatives context biogas promising candidate easily utilized engines vehicular well decentralized power generation applications primary constituents raw biogas methane defines heating value carbon dioxide acts like diluent dilution effect reduces flame speed heating value biogas eventually deteriorating engine performances present article focuses experimental evaluation quantification variations engine performance three compositions biogas containing volume respectively studied small engine dual fuel mode moreover evaluate individual process inefficiencies exergy analysis based second law thermodynamics implemented exergy balances different compositions biogas presented biogas dual fuel operation showed diesel substitution lower engine loads higher loads total irreversibility engine increased diesel operation biogas compositions respectively furthermore combustion irreversibility found decreasing higher concentrations biogas showed comparable results diesel operation second law efficiencies respectively elsevier ltd rights reserved
particle swarm optimization pso genetic algorithms used minimize cost permanent magnet synchronous generator concentrated windings tidal power applications use matlabs global optimization toolbox possible run several optimization algorithms problem combine two stochastic solvers pso gradient based solver fmincon produce two hybrid optimization solvers shown complex machine design problem tight constraints narrow solution space difficult solve pso pso unable find optimal value hybrid versions pso gave better results average minimum costs found hybrid pso hybrid times global minimum integer value set optimal value hybrid found mean cost times global minimum algorithms necessary increase population size improve fitness functions reduce variance
study developed artificial filter bank afb emulates auditory system order efficiently obtain significant dynamic responses developed afb composed digitally coded band pass filter optimizing algorithm boa peak picking algorithm ppa developed afb optimized using random centro earthquake wave often used structural dynamic studies reconstructed signal compressed signal compared original signal using reconstruction error compressive ratio afb developed designed evaluated study adequately captures time frequency information original signal capturing significant dynamic response compressed frequency range interest also digitally developed afb overcomes shortcomings conventional analog filter banks supporting quick easy software based implementation new logics optimizations designs ultimately afb developed study expected provide new paradigm structural health monitoring construction structures well structures authors published elsevier ltd
coupled equations incoherent optical spatial solitons nonlocal nonlinear medium studied analytically soliton solutions hereby obtained via symbolic computation optical soliton motion nonlocal nonlinearmedium studied psi inversely related kappa omega delta positively related omega delta independent kappa psi slowly varying amplitude beam delta refractive index change kappa beam intensity distribution omega frequency propagating beam unperturbed refractive index head overtaking interactions observed head interaction transformed overtaking one increasing bound state interaction displayed increasing period decreases delta increases considering external forces nonlocal nonlinear medium explore chaotic motions nonlinear nonlocal medium including effects external forces motions seen vertical bar alpha vertical bar vertical bar omega vertical bar vertical bar alpha vertical bar vertical bar kappa vertical bar two dimensional attractors stretching folding structures exhibited developed chaos occurs alpha alpha amplitudes external forces speed light vacuum chaotic motions weakened omega kappa omega bar omega bar increasing decreasing omega bar omega bar represent frequencies external forces
many automated finite state machine fsm based test generation algorithms require characterising set set harmonised state identifiers first produced previously published algorithms partial fsms brute force algorithms exponential worst case time complexity paper presents polynomial time algorithms also massively parallel implementations polynomial time algorithms brute force algorithms experiments parallel algorithms scaled better sequential algorithms took much less time interestingly parallel version polynomial time algorithm fastest sizes fsms parallel version brute force algorithm scaled better due lower memory requirements
aims objectives focus sexual health rights study describes transgender people experience meetings health care professionals background transgender people face prejudice discrimination worldwide little known experiences sexual health promoting settings method within descriptive design persons aged identifying transgender nonbinary interviewed results analysed constructivist grounded theory results disrespect among health care professionals core category connected experiences result transgender people experience estrangement expectations eviction different sexual health promoting settings conclusion transgender knowledge needs increased general specialised transgender health care many health care settings prevent transgender peoples experiences estrangement moreover increased knowledge respect sexual health rights needed prevent transgender peoples exposure gender binary cis heteronormative expectations addition access sexual health care essential following gender confirmatory care well avoid transgender peoples experiences eviction health care system relevance clinical practice nurses important role play striving equity justice within health care study describes health care professionals appear disrespectful suggestions avoided made
background aimsstudies assessing hiatal hernia related effects lung volumes derived body plethysmography limited aimed evaluate effect hernia size lung volumes including assessment body plethysmography relationship functional capacity well impact corrective surgery methodsseventy three patients years female large meanstandard deviation intra thoracic stomach type iii respiratory function data spirometry body plethysmography diffusing capacity underwent surgery respiratory function analysed relation hernia size groups iii respectively functional capacity post operative changes quantified subgroup resultstotal lung capacity tlc vital capacity correlated inversely hernia size tlc predicted groups iii respectively predicted however mean values normal abnormal lung volumes surgery increased tlc predicted decreased residual volume total lung capacity tlc ratio respiratory changes modest relative marked functional class improvement among parameters improved following surgery decreased tlc forced expiratory volume increased tlc ratio correlated poorer functional class pre operatively conclusionsincreasing size correlates reduced tlc surgery improves lung volumes gas trapping however changes mild within normal range
background biologics seem offer promising nonsurgical approach hidradenitis suppurativa especially disease highly pronounced inflammation recent studies revealed increased expression broad range cytokines lesional skin including interleukin objective study undertaken determine serum levels group patients methods study conducted group patients years age total matched healthy volunteers constituted control group enzyme linked immunosorbent assay kits used quantify serum concentration results mean serum level patients significantly elevated compared found healthy volunteers moreover tendency toward higher serum concentrations patients advanced disease disease duration patient sex age body mass index smoking habits determining factors serum concentration limitations hospital based study population limitation lack posttreatment assessment conclusion light findings literature increased expression lesions evaluating clinical effectiveness using anti agents treatment patients justified
introduction subjective cognitive decline scd could indicate preclinical alzheimer disease existing literature confounded heterogeneous approaches studying scd assessed differential cognitive affective neuroimaging correlates two aspects scd reporting high cognitive difficulties self rated questionnaire versus consulting memory clinic methods compared patients memory clinic isolated scd community recruited elders similarly high levels self reported cognitive difficulties community recruited controls low self reported cognitive difficulties results increased anxiety amyloid beta deposition observed groups high self reported difficulties whereas subclinical depression hippocampal atrophy specifically associated medical help seeking cognitive tests showed group differences discussion results validate concept scd community clinic based groups yet recruitment methods influence associated biomarkers affective symptomatology highlighting heterogeneous nature scd depending study characteristics alzheimer association published elsevier inc rights reserved
spin change dynamics model ultra cold hyperfine spin atoms confined optical superlattice discussed first disturbance two site dynamics coupling dimer spin ancilla analyzed dimer coupled ancilla even weak coupling significant changes system time evolution processes observed next show twoparticle case total hyperfine spin singlet state generated exploiting quadratic zeeman shift realistic values strength external magnetic field evolution period time moreover even weak coupling regime proper choice additional ancilla dimer interaction results generating wave function characteristic homogeneous three site ring consequence wave function exhibits translational invariance symmetry despite strong asymmetry lattice furthermore present proposal extracting various kinds maximally entangled states mes three site spin systems starting initial product states particular show type generated mes unambiguously recognized measurement performed ancilla
nodular lymphocyte predominant hodgkin lymphoma nlphl indolent lymphoma scarcity made clinical trials difficult consensus first line treatment conducted population based study patients diagnosed nlphl sweden women men focusing clinical features therapy overall survival median female male age years respectively early stage disease little mortality survival differences therapies patients advanced stage disease mortality relatively high patients receive first line rituximab absent year survival imbalances prognostic factors two groups advanced stages first line rituximab use increased markedly year survival multivariate although patients diagnosed longest followed largest population based cohort report hitherto unreported year median age difference sexes increasing rituximab use improved survival
objective study aimed investigate frequency familial mediterranean fever fmf coexists diseases determine whether mediterranean fever mefv gene mutations involved coexistence material methods total consecutive patients fmf investigated mefv mutation enrolled study female male mean age years patients questioned presence concurrent disorders medical records patients revised retrospectively previous diagnosis inflammatory disorder fmf considered true met relevant criteria mefv mutations divided groups namely subgroup homozygous heterozygous group others group compound heterozygosity mutation included group form homogeneous group group group group compared according phenotypical features presence mefv mutation investigated exons multiplex pcr reverse hybridization method results concomitant disorders found patients fmf group patients group concomitant disorders group follows cases amyloidosis cases behcet disease cases ankylosing spondylitis case antiphospholipid syndrome case henoch schonlein purpura hsp case combination psoriatic arthritis hsp membranoproliferative glomerulonephritis case amyloidosis group following disorders found case amyloidosis case case case ulcerative colitis case vitiligo conclusion presence mutation may predispose patients fmf developing inflammatory disorders
ambient vibration measurement output data dynamic testing natural excitations represented instance winds typhoons modal identification involving output measurements requires use specific modal identification techniques paper presents application reliable method stochastic subspace identification ssi implemented general purpose software criterion toward robustness identified modes bio inspired optimization algorithm highly nonlinear objective function introduced order find optimal deployment reduced number sensors across large civil engineering structure validation modal identification ting kau bridge tkb one longest cable stayed bridges situated hong kong chosen case study results show proposed method catches eigenvalues eigenvectors even reduced number sensors without significant loss accuracy
rapid sensitive selective accurate method developed quantitative determination levonorgestrel lng rat plasma validated specificity linearity accuracy precision sensitivity matrix effect recovery efficiency stability liquid liquid extraction procedure using hexane ethyl acetate mixture ratio employed efficiently extract lng rat plasma reversed phase luna column installed sciex triple quad system used perform chromatographic separation lng identified within min high specificity linear calibration curve drawn within concentration range developed method validated intra day inter day accuracy precision whose values fell acceptable limits matrix effect found minimal recovery efficiency three quality control concentrations low medium high found stability lng various stages experiment including storage extraction analysis evaluated using samples results showed lng stable conditions validated method successfully used study pharmacokinetics lng rats subq injection providing applicability relevant preclinical studies elsevier rights reserved
paper mainly studies image contour detection algorithm distinguish edges different strengths based study probability boundary operator find defects response suppression offset exist algorithm detection corners curved edges thus improved algorithm proposed algorithm retains advantage probability boundary algorithm effectively distinguish edge strength improves mentioned defects improved algorithm proposed characterize strength boundary reasonably making test results line human subjective recognition results
objective research findings indicated mothers children diagnosed life threatening illnesses risk posttraumatic stress disorder ptsd symptoms ptss african american mothers especially vulnerable evidence suggesting higher rates ptsd among african americans women race ethnicity past trauma exposure interaction variables evaluated risk factors ptss depression state trait anxiety among african american caucasian mothers chronically ill children method mothers children diagnosed life threatening illness cancer type diabetes mellitus tdm completed standardized measures provided salivary cortisol sample attending medical appointments ill children results mancova revealed mothers children diagnosed tdm higher cortisol levels mothers children cancer racial ethnic disparity risk ptss among mothers conclusion findings suggest mothers children tdm may vulnerable stress reactions reflected cortisol biological marker clinicians researchers might consider illness specific features evaluating risk stress reactions among mothers children life threatening illnesses
aim review provide current state knowledge usefulness modern genetic technologies uncovering causality isolated multiple congenital anomalies array comparative genomic hybridization next generation sequencing revolutionized clinical approach patients phenotypes technologies enable early diagnosis especially clinically challenging newborn populations help uncover genetic defects associated various phenotypes application complementary methods could assist identifying many variants may simultaneously involved development number isolated multiple congenital anomalies technologies carry serious variant misinterpretation risks well therefore methods variant classification accessible variant databases mentioned useful strategy clinical genetic testing application methodologies presented finally future directions challenges briefly commented review
kit pathway important development many mammalian cells organs indispensable development hematopoiesis melanocytes primordial germ cells loss function mutations kit lead perinatal death mouse embryos previously kit used one salivary epithelial stem progenitor cell markers mouse specific temporo spatial expression pattern function developing murine submandibular gland smg still unclear used quantitative real time pcr situ hybridization immunohistochemistry analysis detect kit expression development murine smg found kit expressed epithelia developing smgs embryonic day initial bud stage postnatal day smg completely mature kit expression end bud epithelium increased prenatal development gradually decreased birth expression undetectable mature acini moreover kit expressed smg primordial cord initial bud pseudoglandular canacular terminal end bud stages kit also expressed presumptive ductal cells adjacent developing acini late terminal end bud stage kit expression could detected ductal cells however kit expression detected ductal cells expression increased dramatically taken together findings describe spatial temporal expression pattern kit developing murine smg suggest kit may play roles epithelial histo morphogenesis ductal progenitor cell homeostasis smg
background hard water associated atopic dermatitis eczema wanted determine baby cleanser individual components altered free ionized calcium simulated hard water baby bath studies vitro determination free simulated hard water baby bath vivo exploratory study free absorption skin hard water performed methods free measured ion sensitive electrode vitro hard water ppm addition cleanser components exploratory study absorption skin hard water determined three female participants aged years results use dilution test cleanser reduced free similar ppm ppm use dilution bound virtually free anionic surfactant component contributed effect exploratory vivo study measured reduction similar free simulated hard water minutes conclusion baby cleansers bind free reduce effective water hardness bath water reducing amount free water reduce availability ion binding skin altering reducing free concentrations bath water may important parameter creating ideal baby bath
automated computer vision based fire detection gained popularity recent years every fire detection needs fast accurate paper new fire detection method using image processing techniques proposed explore create fire flame based colour space via linear multiplication conversion matrix colour features sample image show matrix multiplication result differentiating colour space fire part highlighted non fire part dimmed particle swarm optimization pso sample pixels image used obtain weights colour differentiating conversion matrix medoids provides fitness metric pso procedure obtained conversion matrix used fire detection different fire images without performing pso procedure allows fast easy implementable fire detection system empirical results indicate proposed method provides qualitatively quantitatively better results compared conventional state art algorithms elsevier ltd rights reserved
retina tagged approachable part brain due common embryonic origin appears promising site investigation psychiatric disorders retinal function assessed best electroretinogram erg obtained large sample patients major depressive disorder matched controls erg cone rod luminance response functions recorded non dilated eyes major depressive disorder patients mdd controls mean age respectively amongst mdd patients drug free mean age medicated patients cone level prolonged wave observed drug free patients prolonged wave discovered averaging implicit time highest wave amplitudes photopic hill medicated patients mixed rods cones wave reduced whereas trend observed pure rod wave reduced mixed rods cones reduced prolonged drug free patients similar pattern could observed terms effect sizes overall medicated drug free mdd patients sharod deficits suggesting anomalies present beyond effect medication interest prolonged cone reduced rod amplitude reported group schizophrenia patients suggesting common neurodevelopmental root major psychiatric disorders published elsevier inc
experimental study hydroxy hho oxy hydrogen cng compressed natural gas fuel mixtures used additional fuels non modified diesel engine via intake manifold substitution diesel fuel three cases experiment performed four cylinders four stroke diesel engine first case non substitute liquid fuel neat diesel operation second case hho lpm addition air mixture operated substituted diesel engine third case hho cng mixture hydroxy cng lpm inducted intake manifold running substituted diesel engine tests stepping motor driver used fuel pump plunger substitute diesel fuel similar pilot diesel injection effects hho hhocng fuels relative neat diesel operations investigated rpm engine speeds expressed engine performance values like brake torque brake power brake specific fuel consumption brake thermal efficiency exhaust emissions nox exhaust gas temperature egt results showed addition hho cng mixture effective improving engine performance providing environmentally friendly attitude exhaust emissions compared neat diesel operations hydrogen energy publications llc published elsevier ltd rights reserved
previous research showed vertical vection could modulate human mood examined possibility using memory recognition task positive negative neutral emotional images high low arousal levels images remembered accidentally participants visual dummy task later presented together novel images vertical vection inducing neutral visual stimuli results showed downward vection facilitated recognition negative images inhibited recognition positive ones modulations incidental memory task provide additional evidence vection influence cognitive emotional processing also provide new paradigm used future vection embodied cognition research
using multi method approach study examined differences parental meta emotional philosophy including parental emotional awareness emotion coaching families anxiety disordered non children aged investigated whether children emotion regulation varied across non groups parent interviewed awareness emotions emotion coaching completed battery questionnaires included measure assessing children emotion regulation engaged parent child discussion task results indicated compared parents non youth parents youth less aware emotions children emotions results varied emotion type parents youth engaged significantly less emotion coaching parents non youth youth identified significantly greater difficulty regulating emotions compared non youth implications role parental meta emotional philosophy youth emotion regulation discussed
assessed whether diversity plant hydraulic traits explain observed diversity plant responses water stress seasonally dry tropical forests sdtfs ecosystem demography model updated trait driven mechanistic plant hydraulic module well novel drought phenology plant water stress schemes four plant functional types parameterized basis meta analysis plant hydraulic traits simulations original updated evaluated field data costa rican sdtf site remote sensing data central america updated model generated realistic plant hydraulic dynamics leaf water potential stem sap flow compared original predictions novel trait driven model matched better observed growth phenology variations among functional groups notably original produced unrealistically small leaf area index lai underestimated cumulative leaf litter biases corrected updated model updated model also better able simulate spatial patterns lai dynamics central america plant hydraulic traits intercorrelated sdtfs mechanistic incorporation plant hydraulic traits necessary simulation spatiotemporal patterns vegetation dynamics sdtfs vegetation models
paper electrical analogous models fractional hereditary materials introduced based recent works authors mechanical models materials viscoelasticity behavior firstly approached using fractional mathematical operators viscoelastic models elastic viscous components obtained combining springs dashpots various arrangements elements used viscoelastic models equivalently modeled electrical circuits spring dashpot analogous capacitance resistance respectively proposed models validated using modal analysis moreover comparison numerical experiments based finite difference time domain method shows long time simulations correct time behavior obtained modal analysis use electrical analogous viscoelasticity better reveal real behavior fractional hereditary materials elsevier rights reserved
developing robust recyclable absorbents water purification great demand control water pollution provide sustainable water resources herein first time reported fabrication kevlar nanofiber knf based composite particles water purification knf knf carbon nanotube composite particles produced large scale automatic injection casting solution ethanol resulted nanofibrous particles showed high adsorption capacities towards various pollutants including metal ions phenylic compounds various dyes meanwhile adsorption process towards dyes found fit well pseudo second order model adsorption speed controlled intraparticle diffusion furthermore adsorption capacities nanofibrous particles could easily recovered washing ethanol general knf based particles integrate advantages easy production robust effective adsorption performances well good recyclability used robust absorbents remove toxic molecules forward application absorbents water purification elsevier rights reserved
background orally disintegrating tablets odts modern form tablets placed oral cavity disperses rapidly tablets advantages particularly good applications children old patients complication chewing swallowing solid dosage forms aim study design formulate evaluate physicochemical properties montelukast odts prevention asthma seasonal allergies methods formulations prepared different amounts super disintegrating agents effervescent bases disintegrant agents flowability compressibility mixed powders evaluated prepared formulations tested hardness thickness friability weight variation drug content wetting time disintegration time dissolution study moisture uptake studies results compressibility index angle repose range respectively hardness thickness friability wetting time content uniformity formulations range respectively disintegration time tablets prepared super disintegrating agents effervescent bases combination two range respectively conclusions mixture powders tablets passed specified tests results showed formulations prepared super disintegrating agents super disintegrating agents effervescent bases shorter disintegration time compared formulations effervescent bases alone
authors evaluated association parkinson disease duration hypertension assessed office measurements hour ambulatory monitoring patients hypertension evaluated office ambulatory blood pressure measurements among participants mean age years women prevalence hypertension according office ambulatory measurements respectively cohen duration inversely associated hypertension diagnosed office measurements odds ratio confidence interval ambulatory monitoring ambulatory patterns showed higher nocturnal among patients long lasting disease conclusion ambulatory monitoring improves detection hypertension compared office evaluation likelihood hypertension decrease course rather pattern shifts towards nocturnal hypertension
pulse gate turn thyristor based voltage source converter gto vsc topology number pulse vscs elementary unit together fundamental frequency mode gto gate control widely used statcom dynamic reactive power compensation electrical network pulse topology generally produces output voltage waveforms contain etc harmonics hardly find application due higher total harmonic distortion thd level paper new model level pulse mvar statcom employing pulse gto vscs fundamental frequency gate switching control methodology capacitor energy storage two stages magnetics designed simulated attenuate harmonics order etc sim power systems toolbox matlab environment operating performance compensator studied regulating voltage power factor correction electrical network results show model acceptable power system applications
recent years research used classical heavyweight encryption technology realise data privacy integrity protection data aggregation wireless sensor networks challenge balance resource constraints complexity deployment study authors proposed lightweight integrity protecting oriented data aggregation scheme wireless sensor networks lipda lightweight secure easy operability preserve data privacy integrity data aggregation wireless sensor network first distance based formation scheme network topology presented balance energy consumption cluster heads structure complex number composes private factor nodes original data composed complex number encrypted additive homomorphic encryption method realise data aggregation without decryption also reliability data ensured using integrity verification method based complex operation theoretical analysis simulation results show proposed scheme lipda meet requirement privacy protection moreover compared related work lipda lower calculation less traffic higher accuracy verifiable completeness
according compression sensing reconstruction algorithm orthogonal matching pursuit omp algorithm problem iteration select optimal atomic optimize omp algorithm design ensures iteration current allowance minimum observation signal proposes kind optimize omp algorithm based fpga realize hardware structure design matrix decomposition part adopts modified cholesky decomposition methods avoid root operation reduce calculation time delay easy fpga implementation whole system adopts parallel computing resource reuse technology improve computing speed reduce resource utilization quartus development environment design rtl description fpga simulation platform simulation simulation results verify validity design
real quadratic number field root integral basis element denoted period length fundamental unit epsilon real quadratic number field also denoted epsilon root unit theorem real quadratic fields says every unit integer ring quadratic field generated fundamental unit also regulator real quadratic cryptography outstanding seen regulator log epsilon plays role group order regulator problem find integer satisfies vertical bar vertical bar approximation given precision computed polynomial time discriminant however fundamental units calculated computer programme short time big numbers long calculations usual algorithm also main problem computing informatics point view determining fundamental units great importance paper construct theorem determine certain real quadratic fields root specific form continued fraction expansion mod square free integer also present general context obtain new certain parametric representation fundamental unit epsilon types fields specialization get fix yokoi invariants support results tables authors published iase
selection reference image important step color balancing however past research currently available methods focus leading lack effective way select reference image color balancing remote sensing imagery mosaic letter proposes novel automatic reference image selection method aims select reference images assessing multifactors according land surface types target images proposed method addresses limitations caused use single assessment factor well selection single image reference traditional methods addition proposed method wider range applications requiring reference image visual experimental results indicate proposed method select suitable reference images benefits color balancing result outperforms comparative methods moreover absolute mean value skewness metric proposed method lower values comparison methods indicates result proposed method best performance color information quantitative analyses metric absolute difference mean value indicate proposed method good ability maintaining spectral information spectral changing rates reduced least proposed method compared methods
paper adaptive predictive control algorithm employed controlling class continuous stirred tank reactor cstr system main contribute paper cstr system discrete time form non symmetric dead zone inputs considered design parameters control algorithm cstr systems much calculated amount control algorithm less considering radial basis function neural networks rbfnn unknown functions approximated mean value theorem utilized algorithm design process based lyapunov analysis method choosing design parameters appropriately signals closed loop system proved semi global uniformly ultimately bounded sguub tracking error converged small compact set simulation example cstr systems studied demonstrate effectiveness proposed approach elsevier rights reserved
aim study examine differences neural processing social information kin friends different levels closeness social network level twenty five female participants engaged cognitive social task involving different individuals social network undergoing functional magnetic resonance imaging scanning detect bold blood oxygen level dependent signals changes greater levels activation occurred several regions brain previously associated social cognition thinking friends thinking kin including posterior cingulate cortex pcc ventral medial prefrontal cortex vmpfc linear parametric analyses across network layers showed came thinking friends activation increased vmpfc lingual gyrus sensorimotor cortex individuals thought friends closer layers network findings suggest maintaining friendships may cognitively exacting maintaining kin relationships
authors show two well known widely employed public key encryption schemes rsa optimal asymmetric encryption padding rsa oaep diffie hellman integrated encryption scheme dhies instantiated one time pad secure strong simulation based security notion selective opening security chosen ciphertext attacks random oracle model schemes obtained via known generic transformations transform relatively weak primitives security sense one wayness indistinguishability ind cca secure encryption schemes authors also show similar result well known fujisaki okamoto transformation generically turn one way secure public key encryption system one time pad ind cca secure public key encryption system authors prove selective opening security comes free transformations dhies rsa oaep important building blocks several standards public key encryption key exchange protocols fujisaki okamoto transformation versatile successfully utilised build efficient lattice based cryptosystems considered schemes first practical cryptosystems meet strong notion simulation based selective opening sim cca security
wind power generation techniques continuing develop increasing numbers doubly fed induction generator dfig based wind power systems connecting shore shore grids local standalone weak networks microgrid applications impedances weak networks large neglected require careful attention due impedance interaction weak network dfig system subsynchronous resonance ssr high frequency resonance hfr may occur dfig system connected series parallel compensated weak network paper discuss ssr hfr phenomena based impedance modeling dfig system weak networks cause two resonances explained details following factors discussed paper transformer configuration different power scale dfig system different parameters lcl filter adopted grid side converter gsc rotor speed current closed loop controller parameters digital control delay basis analysis active damping strategies hfr using virtual impedance concept proposed
prove vanishing viscosity limit navier stokes boltzmann equations see euler boltzmann equations see three dimensional compressible isentropic flow radiation hydrodynamics shown reasonable assumptions radiation coefficients exists unique regular solution navier stokes boltzmann equations degenerate viscosities arbitrarily large initial data far field vacuum whose life span uniformly positive vanishing viscosity limit worth paying special attention fact via introducing two different symmetric structures applying techniques dealing complexity caused strong coupling fluid radiation field also give uniform estimates rho gamma del rho rho provide convergence regular solution viscous radiation flow inviscid radiation flow see zhu infinity space element rate epsilon elsevier inc rights reserved
study examined whether victimization associated negatively distorted social cognition bias specific increased sensitivity social negative cues assessing perception social exclusion consequences psychological wellbeing moods fundamental needs self reported peer reported victimization participants age years girls measured social exclusion manipulated inclusion versus exclusion virtual ball tossing game cyberball children perceptions psychological well general negative exclusion inclusion moreover self reported peer reported victimi zation associated perception excluded receiving ball less well negative moods less fulfillment fundamental needs regardless excluded included cyberball game contrast peer reported victimization associated negative mood lower need fulfillment exclusion condition together results suggest children indicate victimized negatively distorted social cognition whereas children victimized according peers experience increased sensitivity negative social situations results stress importance distinguishing self reported peer reported victimization implications interventions aimed victimized children social cognition elsevier inc rights reserved
previously showed paternal cocaine exposure reduced reinforcing efficacy cocaine male offspring sought determine whether paternal cocaine experience could also influence anxiety levels offspring male rats allowed self administer cocaine controls received saline passively days bred naive females measures anxiety cocaine induced anxiogenic effects assessed adult offspring cocaine sired male offspring exhibited increased anxiety like behaviors measured using novelty induced hypophagia defensive burying tasks relative saline sired males contrast sire cocaine experience effect anxiety like behaviors female offspring challenged anxiogenic anorectic dose cocaine anxiety like behavior enhanced animals equal degree regardless sire drug experience since anxiety depression often morbid also assessed measures depressive like behavior sire cocaine experience effect depression like behaviors measured forced swim task among male offspring separate group naive littermates select neuronal correlates anxiety measured male offspring cocaine experienced sires showed increased mrna protein expression corticotropin releasing factor receptor hippocampus together results indicate cocaine experienced sires produce male progeny increased baseline anxiety unaltered subsequent cocaine exposure
introduction large proportion individuals gambling disorder also present history alcohol dependence studies directly examined relationship two conditions study primary secondary aims examine relationship personality traits occurring lifetime current past alcohol dependence status accounting differences gambling characteristics occurring psychiatric disorders among problem pathological gamblers recruited community methods problem pathological gamblers completed measures personality traits gambling characteristics gambling severity gambling involvement delayed discounting monetary rewards clinically interviewed occurring psychiatric disorders results occurring lifetime diagnosis alcohol dependence associated lower personality scores control well achievement traditionalism harm avoidance well higher scores alienation tellegen waller bivariate analyses problem pathological gamblers lifetime alcohol dependence reported greater lifetime gambling severity greater past year gambling involvement steeper delayed discounting greater likelihood current lifetime substance dependence lifetime antisocial personality disorder current unipolar mood disorders multivariate analyses indicated lower control traditionalism well occurring lifetime substance dependence diagnosis best accounted occurring lifetime alcohol dependence diagnosis problem pathological gamblers conclusions problem pathological gamblers occurring lifetime alcohol dependence demonstrate addictive behavior across multiple domains report personality style characterized hopelessness impaired control resistance externally motivated treatment approaches implications treatment complex cases discussed elsevier ltd rights reserved
objective assess incidence risk factors cardiovascular events patients psoriatic arthritis psa methods cohort analysis conducted involving patients recruited followed period large psa clinic participants assessed month intervals according standard protocol collected information included demographics lifestyle habits medical history medications use psa related outcomes primary outcome composite major cardiovascular end point comprising myocardial infarction ischaemic stroke revascularisation cardiovascular death association features disease activity occurrence cardiovascular events assessed using cox proportional hazard models results total patients psa analysed follow period cardiovascular events occurred considerable proportion patients developed cardiovascular event patients age years patient age years trend risk developing cardiovascular events observed decades multivariate analysis following variables independent predictors major cardiovascular events hypertension relative risk diabetes number dactylitic digits sedimentation rate significant predictor among women conclusion significant proportion patients psa develop cardiovascular events course disease increased cardiovascular risk associated combination traditional cardiovascular risk factors disease activity
background considerable lack scientific estimate psychiatric morbidity among indian prisoners objective objective following study study prevalence psychiatric morbidity among prisoners settings design cross sectional study district jail kozhikode kerala materials methods total prisoners inmates period mid april mid july participated study study subjects included male female remand convict prisoners socio demographic data clinical history criminological history collected individual psychiatric morbidity assessed using mini plus statistical analysis done using spss version spss inc chicago usa results total subjects current mental illness substance use disorder common diagnosis antisocial personality disorder diagnosed adjustment disorder mood disorder psychosis another prisoners high rate current psychiatric disorder seen male prisoners significant association noticed different nature crimes psychiatric diagnoses previous imprisonment nearly prisoners reported moderate high suicide risk conclusion mental health problems among prisoners quite high mentally ill prisoners high risk repeated incarceration increased rate psychiatric disorders concern mental health professionals policy makers
schizophrenia scz neurodevelopmental psychiatric disorder cognitive function becomes disrupted early stages disease although mechanisms underlying cognitive impairments remain unclear methyl aspartate receptors nmdar hypofunctioning prefrontal cortex pfc implicated moreover cognitive symptoms scz usually unresponsive treatment current antipsychotics onset disruption dopamine system nmdar hypofunctioning dominates symptoms therefore treating cognitive deficits early stage realistic approach study tested whether early treatment targeting mglur would effective ameliorating cognitive impairments methylazoxymethanol acetate mam model scz investigated effects mglur agonistimglur antagonist nmdar expression function juveniles well cognitive deficits adult rats juvenile treatment found gestational mam exposure induced significant decrease total protein levels nmdar subunit nrb significant increase pnrbtyr juvenile rat pfc treatment juvenile mam exposed rats effectively recovered disrupted nmdar expression furthermore subchronic treatment juvenile mam exposed rats also alleviated learning deficits cognitive flexibility impairments tested cross maze based set shifting task adults therefore study demonstrates targeting dysfunctional nmdars mglur agonist early stage scz could effective strategy preventing development progression addition ameliorating cognitive impairments scz elsevier inc rights reserved
paper introduces wearable feedback device aims relaxing user stressful situations system called wearelaxable provides various feedback modalities vibration ambient light acoustic stimuli heat order reduce user stress level development wearelaxable based two studies first five kinds feedback appropriate body positions stimulation evaluated participants based findings initial study built wearable arduino prototype prove feasibility concept experience using system tested test subjects laboratory conditions conclude concept design wrist worn device provides acoustic visual feedback tactile stimulation shirt would provide vibration positions shoulders well heat loins users explicitly activate system time combination feedback modalities
borderline personality disorder bpd associated negative self images however remained underexplored whether bpd patients hold negative views personal future receiving information possible future live events healthy participants tend update estimates toward desirable toward undesirable information test whether bpd patients process information future negative fashion healthy controls participants rated probability experiencing adverse life events receiving statistical information average probability events bpd patients first estimated probability experiencing negative life events higher healthy controls however receiving information life events estimates two groups differ groups updated estimates toward desirable toward undesirable information thus findings suggest nuanced picture outset bpd patients appear pessimistic might able overcome pessimism provided relevant information taken together bpd patients initially pessimistic personal future healthy controls groups showed positively biased updating without evidence differences bpd patients
article presents estimation impact distributed energy resources der electrical network power losses using novel quasi dynamic analytical approach contribution distributed generation network power losses estimated slow dynamics simulations performed differently controlled order clarify importance impact different voltage power control strategies
italian white certificate scheme main national policy instrument incentivise energy efficiency industrial sector savings white certificates amounting italy primary energy consumption mechanism sets binding energy saving targets electricity gas distributors least clients includes voluntary opt model participation parties paper investigates assesses elements scheme help overcome several barriers deliver industrial energy efficiency results survey conducted among leading experts indicate italian system provides strong financial incentive energy efficiency investments covering significant share investment costs thus reducing payback time moreover scheme fosters development energy service companies escos key developing installing arranging finance projects ground conjunction policies mechanism also raises awareness energy efficiency investment opportunities thus helping overcome market failure insufficient information core challenges remain including tackling regulatory uncertainty improving access finance
passive film nuclear grade stainless steels evaluated quantifying color changes coloration reactions compared using ferroin blue dot solutions indicators basis measured results laboratory reactions applied stainless steel valves nuclear power plant degree color change indicates degree growth passive film ferroin solution exhibits higher accuracy stable blue dot solution determining passive film quality potentiodynamic polarization curves show blue dot solution might cause surface damage compared ferroin solution inspection result stainless steel valves supports laboratory result however stainless steel exhibited dramatic decrease sensitivity blue dot intrinsic instability high acidity solution ferroin solution superior blue dot solution stainless steel facilities nuclear power plant elsevier rights reserved
cessation self efficacy shown consistent predictor smoking cessation outcomes date scale assessing cessation self efficacy validated across smokers without psychiatric diagnosis current past smokers psychiatric diagnosis typically heavy smokers difficult time quitting prone experience lower self efficacy determining whether smoking cessation self efficacy scores invariant across populations crucial future research intervention strategies data flexible extended dosing nicotine replacement therapy nrt varenicline comparison fixed dose nrt smoking cessation flex trial randomized control trial smoking cessation used assess factor structure smoking cessation self efficacy questionnaire seq item scale assessing individual confidence refrain smoking confirmatory factor analysis cfa used compare model fit original factor structure present data test measurement invariance across current past psychiatric diagnosis initial support found factor structure using cfa factor model displayed adequate fit indices global fit index gfi results model comparisons showed differences current past psychiatric diagnosis cmin factors highly correlated indicative underlying global factor seq found measurement invariant across treatment seeking smokers preliminary evidence suggesting valid measurement scale evaluating overall cessation self efficacy regardless psychiatric status
wartime violence affect public attitudes toward government long run paper examine whether violence civilians korean war continues influence people attitudes toward south korean government half century later find wartime violence clear long term attitudinal effects using difference differences analysis compares cohorts born war findings indicate people experienced violence childhood years less supportive south korean government especially administration military compared born areas years war argue gap pre post war cohorts generated long lasting trauma wartime violence social stigma imposed violence victims war
reward predictive stimuli augment instrumental reward seeking humans effect denoted pavlovian instrumental transfer pit role differential reward value stimuli emotional conditioned responses pit remains unknown fifty one participants experienced pavlovian phase associated two stimuli either next participants underwent instrumental training two responses reinforced either finally transfer phase continued instrumental training presence pavlovian stimuli participants dichotomised aware unaware according expectancy awareness outcome associations aware participants demonstrated pit increased choice number responses response key presence respectively yet aware unaware groups rated stimulus pleasant stimulus findings suggest expectancy reward necessary pit however emotional conditioned responses appear sufficient influence pit future research attempt manipulate emotional conditioned responses pit context test sufficiency reward expectancy pit published elsevier
objectives investigate impact occupational skin disease consultations among outpatients dermatological department university hospital northern norway study design patients occupational skin disease examined given advice skin care skin disease treatment skin protection work legal rights patients disease ten fifteen years later wanted look patients terms work situation current status disease help received labour offices subjective quality life material methods autumn spring number patients examined period selected sent questionnaire asked answer return regarding work situation progress current status occupational disease results total patients answered questionnaire patients still work old age retired working retired early disability changed jobs occupational skin disease patients indicated skin disease improved since previous investigation conclusions investigation patients occupational skin disease documented majority patients received professional dermatological consultation intervention offers still labour market good control skin disease years later discovered patients still employed remained work became old age pensioners dropped work disability high percentages may indicate intervention contributed positively patients work conditions course skin disease
epidemiological studies demonstrated clear phenomenological association low birth weight increased cardiometabolic risk later life similar high birth weight subjects pre neonatal overfeeding appears etiological clue animal studies irrespective birth weight neonatal nutrition leads later overweight impaired glucose tolerance cardiometabolic alterations probably perinatally acquired alterations dna methylation patterns gene promoters central nervous regulators body weight metabolism play key role mediating relationships humans long term impact neonatal nutrition conclusively demonstrated studies consequences breastfeeding formula feeding taken together quantity quality nutrition neonatal life plays critical role beyond prenatal development long term programming health disease opens variety opportunities challenges primarily prevent chronic diseases metabolic syndrome elsevier ltd rights reserved
real time visualization scenes important feature many computer graphics solutions applications computer aided design scientific visualization even growing computer games market performance visualization becomes essential addition complexity scenes increasing contain objects composed thousands even millions polygons moreover emergence new standards new supported functionalities web mobile environments enable efficiently render complex scenes however environments gpu capabilities partially supported therefore necessary resort different techniques allow maintain quality performance applications managing huge amount geometry environments among different solutions many authors concentrated level detail approaches main objective paper introduce studies topic presenting different solutions currently exist field real time visualization level detail models fits gpu limited environments web mobile platforms
study conducted determine performance low cost plantar measuring device aim device establish shoe measurement system high resolution take relatively accurate measurements calibration method smart material established use kistler force plate coefficient determination force resistance calibration curve residual standard deviation amounted value repetitive loading experiments amounted residual standard deviation forces larger data obtained insole deemed sufficiently accurate quantitative analysis authors published elsevier ltd
introduction fractional concentration exhaled nitric oxide feno biomarker airway inflammation repeat feno maneuvers multiple fixed exhalation flow rates extendednoanalysis used estimate parameters quantifying proximal distal sources mathematical models lower respiratory tract growing number studies use extendednoanalysis official standard flow rate sampling protocol paper provide information study planning deriving theoretically optimal flow rate sampling designs methods first reviewed previously published designs nonlinear regression framework estimating parameters steady state two compartment model identified unbiased optimal four flow rate designs within range using theoretical derivations simulation studies optimality criteria included parameter standard errors ses asimulation study used estimate sample sizes required detect associations parameters estimated studies different designs results designs unbiased noparameter ses smaller designs target flows replicate maneuvers per target flow larger range target flows high flows important estimating alveolar concentration low flows important proximal parameters southern california children health study design fold larger ses required fold subjects detect association determinant parameter compared optimal design conclusions class reasonable flow rate sampling designs good theoretical performance practice designs selected balance tradeoffs optimality feasibility flow range total number maneuvers
research work carried order develop motorized akpu milling machine quest improve poverty eradication nigeria technological innovation considering various traditional method grinding akpu cassava machine fabricated ability grind tubers akpu cassava squeezing extracting moisture content frying fire oven research work aimed eliminating problem traditional method milling akpu capacity akpu milling machine developed machine runs single phase three horse power electric motor speed rpm due inherent problems contamination machine may adopted large scale industrial applications
new systematic design procedure square root domain rootx domain circuits based signal flow graph sfg synthesis approach introduced paper sfg prototype system modified using proposed set operators way rootx domain building blocks could used corresponding implementations purpose new rootx domain integrator circuits proposed constructed new current mode geometric mean multiplier divider circuits main advantages proposed circuits accuracy due immunity body effect low circuit complexity potential low voltage operation example fifth order chebyshev low pass filter designed using proposed technique simulation results confirm validity proposed design technique high performance proposed circuits
new adaptive filtering algorithm time series data based qrd inverse updates method pan plemmons derived first principles common fast algorithms time series adaptive filtering algorithm requires operations solution pth order problem unlike previous fast algorithms based qrd technique algorithm presented explicitly produces transversal filter weights furthermore derivation algorithm achieved quite simply means signal flow graph manipulation relationship fast qrd inverse updates algorithm ftf algorithm briefly discussed results preliminary computer simulations algorithm using finite precision floating point arithmetic presented
developed surgery support system robot assisted laparoscopic partial nephrectomy system computer graphics dcg model includes kidney arteries veins tumors saved separately overlaid surgeon viewing endoscopic camera image operator console monitor real time position orientation dcg model calculated optical flow endoscopic camera images model moved semi automatically display condition part dcg model independently controlled anytime using mouse rotary controllers key board
desalination driven solar energy represents appealing solution agricultural irrigation remote areas work desalination system based photovoltaic powered nanofiltration membrane studied experimental work explored effect influent concentration solar radiation permeate production energy consumption recovery rate quality permeate product four cases different inlet conditions influent concentrations studied set influent concentration kept constant varying irradiance along solar day addition unit cost permeated water estimated maximum tested energy consumption kwh concentration total dissolved solids system produces permeate water unit cost
study relationship heuristics standard tool application design process control systems relationship illustrated classical control history examples features modem engineering objects highlighted challenge classical control approach leave substantial space creative solutions focus inevitable heuristics control design modem complex process systems study suggests new systematic approach heuristic control design approach based simplification technique follow three steps first certain assumptions negligible nonlinearity dynamic behavior help develop simplified model problem setup second standard control design performed reduced model third perturbation theory methods help find corrections obtained control cope real plant special attention given paradigm concurrent integrated plant control design study suggests finding proper compromise investments process control several cement manufacturing process examples demonstrate method generate better effect comparing autonomous approach institution chemical engineers published elsevier rights reserved
emotional disorders related attentional memory biases especially emotional material recent research shown depression dysphoria high internalizing traits related increase false memories negative events however clear whether anxiety alone may imply effect whether applies emotional events negative ones present study examined questions using paradigm based pictorial scripted material analyze inferential memory errors negative positive neutral everyday events high anxious control young adults results showed increase negative positive inferential false memories high anxious individuals even controlling depression level contrary negative material reduced false memories control participants supporting previous research concluded high trait anxiety enhances elaboration negative emotional material eventually leads misremember causal antecedents negative events previously experienced inferred elsevier ltd rights reserved
article explores canadian youth participate gay straight alliances gsa teachers advise perceive experience pansexuality participants perspectives definitions alignment pansexuality examined unpack mis understandings associated nonmonosexual identities gsa members bisexual pansexual identity labels interchangeable terms bisexuality associated male binary pansexuality served personal contestation dichotomy despite distinctions nonmonosexualities marked invisibility mis understandings prejudice school findings emphasize students knowledge sexual diversity fluidity wasmore nuanced gsa advisors due personal online research gsa participation enabled pansexual knowledge exchange among students teachers promoted overall understandings pansexualities although gsa involvement facilitated opportunities discuss pansexualities article also highlights effort made integrate pansexual content clubs
reversible circuit synthesis important field quantum computing low power design reversible circuit problem reversible circuit synthesis complicated hard solve input reversible circuit experience huge increase extended multi bit paper novel algorithm reversible circuit synthesis proposed satisfied priority positions efficiently select position satisfied selected gate generated benefit overall situation therefore proposed algorithm able optimize reversible circuit fewer gates implemented regard multibit reversible circuit synthesis addition gate set used contains toffoli spanning wires toffoli gate liable transformed another gate set helpful algorithm design experiment shows proposed algorithm efficient optimal results superior others
type diabetes mellitus tdm chronic autoimmune disease affecting around million people world pathophysiology based malfunction glucose homeostasis given deficiency production insulin hormone pancreas therefore ingestion high carbohydrate meal patient condition able recover back right plasma glucose concentration nowadays exists approach treat condition control engineering based development artificial pancreas able provide needed doses insulin glucagon given time however one main concerns development artificial pancreas provide automatic controller reliable mathematical model physiology treated patient order perform right decision making although literature mathematical modeling diabetes quite vast purpose paper provide update recent advances diabetes modeling mainly related glucose homeostasis review mainly focused developments last ten years
objective adolescents young adults depressive symptoms highly prevalent dynamic clinicians difficult determine whether young person reporting depressive symptoms risk developing ongoing mood difficulties whether symptoms form part transient maturational process trajectory analyses longitudinally assessed symptoms large cohorts potential untangle clinical heterogeneity determining subgroups classes symptom course risk factors interrogating impact known suspected risk factors trajectory slope intercept tracing interrelation depressive symptoms clinical outcomes time method conducted systematic review trajectory studies conducted cohorts including people aged years results retrieved relevant articles studies suggest young people fall common mood trajectory classes class membership symptom course mediated biological environmental risk factors furthermore studies provide evidence high persistent depressive symptoms associated range concurrent health behavioral outcomes conclusion findings could assist formulation novel concepts depressive disorders young people inform preventive strategies predictive models clinical practice
numerical aspects central importance identification control many computations fields involve approximations using polynomial rational functions obtained using orthogonal oblique projections aim paper develop new general theoretical framework solve large class relevant problems proposed method built introduction orthonormal polynomials respect data dependent linear form linear form generalises conventional inner product allows asymmetric indefinite problems proposed approach shown lead optimal numerical conditioning kappa recent frequency domain instrumental variable system identification algorithm comparison shown recent algorithms exhibit extremely poor numerical properties solved using traditional approaches
three dimension scaffolds bone tissue regeneration produced combining three different phases nanometric hydroxyapatite synthesized precipitation method crystals nucleation took place directly within collagen fibrils following biologically inspired mineralization process polycaprolactone employed give material structure chemico physical analysis carried test material properties composition revealed high similarity composition morphology biologically mineralized collagen fibrils scaffold degradation pattern suitable physiological processes micro computerized tomography micro showed porosity mean interconnected pores computer aided design computer aided manufacturing cad cam technology used molding scaffold volume design shape guiding surgical procedure cutting guides custom made scaffolds implanted sheep mandible using prototyped surgical guides customized bone plates three months healing scanning electron microscopy sem analysis explanted scaffold revealed massive cell seeding scaffold cell infiltration within scaffold interconnected pores micro explanted construct showed good match scaffold adjacent host bone shield implant primary stability histology confirmed cell penetration widely documented neoangiogenesis within entire scaffold volume wiley periodicals inc biomed mater res part appl biomater
previous research shown exposure violent video games increases aggression whereas exposure prosocial video games reduce aggressive behavior however little known neural correlates behavioral effects work first investigate electrophysiological features relationship playing prosocial video game inhibition aggressive behavior forty nine subjects played either prosocial neutral video game min participated event related potential erp experiment based oddball paradigm designed test electrophysiological responses prosocial violent words finally subjects completed competitive reaction time task crtt based taylor aggression paradigm contains reaction time noise intensity chosen measure aggressive behavior results show prosocial video game group compared neutral video game group displayed smaller amplitudes accurate distinguishing violent words less aggressive evaluated crtt noise intensity chosen mediation analysis shows amplitude evoked violent words partially mediates relationship type video game subsequent aggressive behavior results support theories based general learning model provide converging behavioral neural evidence exposure prosocial media may reduce aggression
aim article design implementation intelligent irrigation devices using arduino microcontroller control interface irrigation system created mobile application currently existing various similar solutions perspective money unprofitable present solution cheap effective especially home usage following extension also applied larger scale buildings greenhouse intelligent garden others used hardware components realization microcontroller arduino yun real time clock two humidity sensors relays solenoid valves application controlling irrigation device using mobile technology created programming language java easy smart irrigation system controlled smart phone tablet operating systems android reactions functions proposed intelligent system verified statistical surveyes results evaluated using technics explorating analysis non parametric levene test analysis determine reliability irrigation equipment clarify behavior system existence systematic random errors
paper discuss design manually operated soil compaction machine used manufacture stabilized soil blocks ssb case study manufacturing three million blocks housing project using manually operated machines illustrated paper focussed design development evaluation manually operated soil compaction machine production ssb also details machine design philosophy compaction characteristics soils employment generation potential small scale stabilized soil block productions systems embodied energy static compaction partially saturated soils performed generate force displacement curves confined compaction process generated based soil compaction data engineering design aspects toggle press illustrated results time motion study block production operations using manual machines discussed critical path network diagrams used small scale ssb production systems production systems generate employment low capital cost
maltreated non maltreated year old children tested deese roediger mcdermott drm false memory task using emotional neutral word lists true recall significantly better non maltreated maltreated children regardless list valence proportion false recall neutral lists comparable regardless maltreatment status however maltreated children showed significantly higher false recall rate emotional lists non maltreated children together results provide new evidence maltreated children could prone false memory illusions negatively valenced information non maltreated counterparts elsevier inc rights reserved
power divider combiner circuit simultaneously achieves wide bandwidth flat gain characteristics bidirectional operation proposed multichannel broadband system applications proposed circuit utilizes cascode based bidirectional amplifier cores steer operation modes divider combiner depending control input two stage distributed amplifier topology artificial transmission lines implemented silicon germanium bicmos technology platform proposed divider combiner provides advantage seamless integration digital control blocks power divider combiner exhibits flat band gain operational bandwidth ghz covers bands addition shows amplitude imbalance phase imbalance degrees port port isolation output compression point dbm good impedance matching power consumption
many efforts devoted modeling diffusive impedance conjugated polymer based actuators using equivalent electrical circuits employing methodology based mechanical sensors also treated equivalent transmission line circuit overall impedance modeled correspondingly due large number resources study electrical circuits technique practical tool therefore study equivalent circuit model including electrochemical parameters determined obtain better perception sensing mechanism mechanical sensors conjugated polymers capable generating output current voltage upon induced mechanical deformation force observed behavior polymer based mechanical sensors considered reverse actuation process many outstanding properties conjugated polymer actuators including light weight biocompatibility still retained sensors sensors trilayer configuration capable operating air response mechanically induced bending deformation however due nonlinear behavior multivariable characteristics required propose systematic approach order optimize performance gain optimal values constituent decision variable therefore proposed mathematical model used define output voltage ppy based mechanical sensor along sensitivity model applied frequency induced deformation applying multiobjective optimization algorithm optimization problem solved tracking ability proposed model verified
prescribed burning widespread management technique wildfire hazard abatement understanding effects tree ecophysiology key defining burn prescriptions aimed reducing fire hazard mediterranean pine plantations pinus pinea stands assessed physiological responses adult pinea trees using combination dendroecological anatomical hydraulic isotopic analyses tree ring widths xylem cell wall thickness lumen area hydraulic diameter tree ring delta delta measured trees burned control sites vulnerability curves elaborated assess tree hydraulic efficiency safety despite relatively intense thermal treatment residence time temperatures degrees stem surface ranged burned trees suffer mechanical damage stems significant reduction radial growth moreover affect xylem structure tree hydraulics variations derived water use efficiency recorded confirmed high resistance pinea surface fire stem base however burned trees showed consistently lower values year likely consequence reduced competition water nutrients due understory burning increased photosynthetic activity stomatal conductance multi approach analysis offers new perspectives post fire survival strategies pinea environment fires predicted increase frequency severity century
numerical model developed framework openfoam open source computational fluid dynamics cfd simulation code simulate particle laden dense flows model uses discrete element method dem discrete particle phase computational fluid dynamics approach cfd fluid continuum phase current study validation model done two steps first step drag model validated comparing results settling velocity spherical particle second step spout fluidization test cases different operating conditions simulated results numerical simulation spout fluidized bed compared experimental simulation results reported literature isosurface plots solid volume fraction show good qualitative prediction different flow regimes particle velocity profiles vertical direction different test cases corresponding different flow regimes plotted compared literature data predictions model good agreement experimental numerical results reported literature elsevier inc rights reserved
introduction objectives currently studies leadless pacemaker micra mostly limited clinical trials less months follow often fail reflect real population outcomes sought evaluate electrical parameters implantation chronologically follow well safety new technique methods prospective observational study included consecutive patients years indication single chamber pacemaker implantation results successful implantation accomplished patients referred leadless implantation mean age years range years men permanent atrial fibrillation atrial tachycardia sinus rhythm concomitant atrioventricular node ablation performed immediately implantation patients implantation performed transcatheter aortic valve implantation procedure performed uninterrupted anticoagulation regimen maximum inr patients exception moderate pericardial effusion without tamponade severe complications mean follow months patients year follow sensing pacing parameters stable implantation short mid term follow conclusions implantation leadless pacemakers feasible safe provides advantages conventional system studies longer follow periods needed devices become widely used routine clinical practice sociedad espanola cardiologia published elsevier espana rights reserved
purpose lichen sclerosus chronic inflammatory skin condition frequently involves anogenital region ongoing research focused finding effective treatments tissue repair reducing symptoms aim study evaluate effectiveness platelet rich plasma prp local injections penile methods forty five male patients affected penile underwent injections autologous prp affected skin areas age diagnosis first treatment number treatments clinical conditions phimosis splitting inflammation synechiae meatus stenosis symptoms pain burning itching functional impairment considered treatment efficacy also evaluated investigator global assessment iga six point likert scale dermatology life quality index dlqi results patient age diagnosis years mean age first prp treatment years number treatments patient ranged follow months prp injections observed patients significant improvement clinical conditions reduction disappearance symptoms topical steroid therapy interrupted prp treatment restarted patient one patient underwent later circumcision procedure iga scale dlqi score showed significant difference prp treatment conclusions prp treatment penile seems helpful regenerate scarring reduce symptoms improve patient quality life studies necessary evaluate long term results
novel biologic agents allowed clinicians achieve improved patient outcomes appropriate pharmacoeconomic analyses demand evaluation relevant costs including treatments disease comorbidities costs alternative treatments including short long term side effects complete data value therapies correctly estimated assessing costs pharmacoeconomic studies complement studies efficacy safety helping determine relationships treatment outcome article provides broad framework understanding evaluating published economic analyses identifying key costs benefits caring patients asthma immune diseases
propose two end view based digital image processing algorithms high precision rotational angle alignment specialty optical fibers first technique based cross correlation calculation images two fiber ends accurate alignment achieved identical specialty optical fibers arbitrary end face structures one based self correlation method two fibers different refractive index profiles fusion splicer rotated preset angles independently high precision accurate angle alignment less degrees uncertainty low average splicing loss seven core multicore fibers achieved experiment speed alignment process proposed two simplified algorithms mentioned techniques time consumption reduced acceptable alignment accuracy confirmed methods suitable kinds specialty optical fibers polarization maintaining fibers photonic crystal fibers
present study evaluated response bias scale rbs symptom validity test embedded within minnesota multiphasic personality inventory mmpi restructured form mmpi assesses feigned neurocognitive complaints sample pretrial incompetent stand trial ist criminal defendants additionally examined improbable failure scale performance validity test embedded within structured interview reported symptoms second edition sirs similarly assesses feigned cognitive impairment fci results indicated rbs area curve auc scale auc achieved moderate classification accuracy using test memory malingering tomm criterion rbs scale appeared useful screening defendants presented genuine specificity respectively less effective classifying defendants suspected feigning according tomm sensitivity respectively order identify significant proportion ist defendants may feigning impairment considerably lower cutoff scores recommended measure manual evaluated rbs score sensitivity specificity scale raw score sensitivity specificity required achieve sensitivity alternate cutoff scores may therefore useful screening inpatient forensic psychiatric ist defendants scales effectively predicted tomm classification combination although rbs significantly contributed model implications assessment fci forensic psychiatric settings discussed
atypical visual perceptual skills thought underlie unusual visual attention autism spectrum disorders assessed whether individual differences visual processing skills scaled quantitative traits associated broader autism phenotype bap visual perception assessed using figure ground subtest test visual perceptual skills edition tvps large adult cohort tvps figure ground scores positively correlated autistic like social features assessed broader autism phenotype questionnaire relationship gender specific males showing correspondence visual perceptual skills autistic like traits work supports link atypical visual perception autism highlights importance characterizing meaningful individual differences clinically relevant behavioral phenotypes
goal treatment patients primary hypothyroidism attain euthyroidism guided stipulated thyroid stimulating hormone tsh levels range minimize potential long term adverse effects however various factors may result levothyroxine replacement study aimed evaluate mean daily dose replacement asian patients primary hypothyroidism secondary aims determine proportion either replaced factors associated thyroid function status replacement adherence data collected using questionnaire survey targeted patients managed typical public primary care center singapore socio demographic characteristics clinical parameters laboratory investigations mean daily replacement doses replacement regimens thyroid status patients classified based thyroid function investigations complete data patients analyzed total patients tsh within normal range replaced respectively asian patients primary hypothyroidism achieved normal tsh status requiring average daily kgbw body weight subjects replaced higher daily tdose kgbw compared euthyroid replaced groups replacement largely due excessive dosage patients younger lower socioeconomic strata higher bmi likely replaced majority asian patients hypothyroidism required replacement daily kgbw thyroid status influenced demographic dosing factors
attention basic cognitive function necessary daily activities beneficial effects cognitive abilities exposure nature reported explore relaxation indoors nature differently affect directed attention physiological measures participants women measured directed attention necker cube pattern control test guided progressive relaxation session indoors outdoors nature additionally systolic diastolic blood pressure heart rate measured relaxation participants environmental preference explored main result showed environmental effect directed attention favour natural environment similar environmental effect physiological measures seen results indicate relaxation natural environments positive effect directed attention hence could important component preventive rehabilitative interventions stress related symptoms
selective serotonin reuptake inhibitors ssris reported potentially associated increased risk bleeding meta analysis observational studies conducted quantify risk case control cohort studies investigating bleeding risk ssri therapy retrieved searching medline pascal google scholar scopus databases case control studies included reported bleeding incidents without use ssris cohort studies included reported rate bleeds among ssri users non users main outcome severe bleeding whatever site data concerning ssri belonging atc class noab used case control cohort studies recorded adjusted effect estimates confidence intervals pooled adjusted odds ratio estimates computed case control cohort studies using inverse variance model meta analysis adjusted ors observational studies showed significant association ssri use risk bleeding random effect model association found case control studies patients increased risk bleeding well cohort studies including patients subgroup analyses showed association remained constant whatever characteristics studies meta analysis shows increased risk bleeding least based high level observational studies ssris use elsevier ltd rights reserved
although many scientific discoveries frequently reported kinds insightful breakthrough suddenly illuminated one mind never exactly know whether afterward reports reliable study subjects asked solve list remote associate test problems got subsets insightfully routinely solved items study examined whether people recollect aha experiences well non aha ones found subjects accurate recollecting aha experiences relative routine ones study examined report bias aha non aha problem solving experiences could changed afterward suggestive information indicated discovery unique rare found tendency participants falsely recollect routine problem solving experience aha ones told item solved rare tendency falsely recollect aha problem solving experiences routine ones item said common
paper presents simple approach load flow analysis radial distribution network embedded generation proposed approach utilizes forward backward sweep algorithm based kirchoff current law kcl kirchoff voltage law kvl evaluating node voltages iteratively approach computation branch current depends current injected neighbouring node current adjacent branch approach starts end nodes sub lateral line lateral line main line moves towards root node branch current computation node voltage evaluation begins fro root node moves towards nodes located far end main lateral sub lateral lines proposed approach tested using three radial distribution systems different size configuration found computationally efficient effectiveness proposed approach demonstrated integrating embedded generation load flow analysis radial distribution network
background patient level data available randomized controlled phase iii phase solifenacin clinical trials methods meta analyses conducted interrogate data broaden knowledge solifenacin overactive bladder oab general integrating data datasets individual studies mapped single format using methodology developed clinical data interchange standards consortium cdisc initially data structure harmonized ensure identical categorization using cdisc study data tabulation model sdtm allow patient level metaanalysis data integrated mapped analysis datasets mapping included adding derived categorical variables followed standards described analysis data model adam mapping sdtm adam performed twice two independent programming teams results compared inconsistencies corrected final output adam analysis sets included assignments patients safety analysis set full analysis set results three analysis groupings analysis group placebo controlled monotherapy fixeddose studies analysis group placebo controlled monotherapy pooled fixed flexibledose analysis group solifenacin monotherapy treated patients treatment groups solifenacin fixed dose solifenacin flexible dose solifenacin fixed dose overall solifenacin patient similar enough data pooling acceptable conclusions creating adam datasets provided significant information individual studies derivation decisions made study validated adam datasets exist medical history efficacy aes results meta analyses similar time authors published elsevier inc open access article license
today huge amount tables presented web pages word documents spreadsheets many unstructured tabular data intended understood humans interpreted machines time often need information structured form relational databases propose rule based approach table analysis interpretation demonstrate applied transform tabular data unstructured spreadsheets structured relational databases form paper discusses representing tabular data facts working memory rule engine formal language defining rules table analysis interpretation implementation
paper provides review key concepts concurrent design different machine types suitable self sensing zero low speed high speed operation impact modifying machine design suitable self sensing power conversion properties average cogging ripple torque presented several classical advanced machine types general recommendations yield self sensing performance good power conversion properties provided induction machines surface permanent magnet machines flux intensifying interior permanent magnet machines variable flux machines variable magnetization state variable leakage flux
active appearance models aams one popular well established techniques modeling deformable objects computer vision paper study problem fitting aams using compositional gradient descent cgd algorithms present unified complete view algorithms classify respect three main characteristics cost function type composition iii optimization method furthermore extend previous view proposing novel bayesian cost function interpreted general probabilistic formulation well known project loss introducing two new types composition asymmetric bidirectional combine gradients image appearance model derive better convergent robust cgd algorithms providing new valuable insights existent cgd algorithms reinterpreting direct applications schur complement wiberg method finally order encourage open research facilitate future comparisons work make implementation algorithms studied paper publicly available part menpo project http www menpo org
aim article address questions paula nurius presents article innovation emerging scientific careers social work prepared compete todays scientific marketplace specifically article focus better prepare emerging research scholars successful innovators trans disciplinary training educational activities article recommends two main ideas first main idea social work host meetings lectures roundtables trainings disciplines tend collaborate order build inter disciplinary partnerships second suggestion students socially integrated via extensive interaction outside disciplines customized semester long rotation style trainings implementing suggestions providing space doctoral students gain understanding different disciplines researchers technologies methods add ability produce innovative ideas encouraging creative complex thinking problem solving
diverticulosis diverticular disease colon common conditions western countries incidence prevalence diseases increasing becoming significant health systems growing body knowledge shifting paradigm pathogenesis treatment diverticular disease low grade inflammation altered intestinal microbiota visceral hypersensitivity abnormal colonic motility identified factors leading diverticular disease risk developing diverticulitis among individuals diverticulosis lower studies indicate diverticular disease may become chronic disorder patients merely acute illness contrary advice international guidelines studies shown high fiber diet protects diverticulosis evidence use antibiotics uncomplicated diverticulitis sparse low quality relation surgery studies support conservative approach prophylactic surgery patients recurrent disease chronic symptoms finally new pathophysiological knowledge suggests treatments may useful mesalamine rifaximin probiotics however research necessary validate safety effectiveness cost effectiveness strategies
high cost traditional stabilizing agents lime cement led research industrial agricultural wastes suitable alternatives rice growing areas kenya accumulate large quantities rice husk pose serious disposal problems burnt means disposal rice husk ash formed difficult coagulate thus contribute air water pollution require large space disposal cause respiratory health problems inhaled red coffee soil poses serious engineering problems swelling due wetting shrinkage due drying low bearing capacity differential settlement leading cracks needs improvement strength stability service red coffee soil rice husks samples obtained gatundu mwea respectively rice husk burnt temperatures degrees ensure maximal formation siliceous component chemical analysis rice husk ash gave sum sio feo alo indicating pozzolanic activity rice husk ash applied weight dry soil plasticity index liquid limit linear shrinkage decreased lean sample rice husk ash stabilized samples whereas plastic limit increased soaked california bearing ratio value rice husk ash stabilized samples increased corresponding soil subgrade class however lime stabilized samples gave higher values
objectives physical activity may positive effects decreasing anxiety stress depression maintaining mental health ensuring psychological vitality study aimed determine physical activity program elderly people nursing homes affected depressive symptoms quality life methods included individuals aged years intervention group controls experimental randomized controlled pretest posttest study besides socio demographic data depressive symptoms quality life assessed standardized procedures beck depression scale bdi quality life questionnaire ten weeks lasting physical activity program consisting min warm activities mintes rhythmic exercices min cool exercises mintes free walking period four days week results contast controls individuals intervention group presented significant decrease bdi physical activity program likewise eight subscales two sub dimensions quality life questionnaire significantly improved experimental group conclusions results suggest structured physical activity program positively impacts depressive symptoms quality life elderly individuals elsevier rights reserved
although childhood health status widely recognized important determinant future achievement health studies impact patient cost sharing children health paper investigates whether reduced cost sharing leads improvement health status among preschool school age children japan exploiting regional disparities expansions municipality level subsidy programs pocket expenditure eligibility subsidy program known medical subsidy children infants msci coinsurance rate generally decreases zero outpatient health care services drug prescriptions order uncover impact program conducted original survey municipalities japan understand time series evolution eligible age msci october weighted response rate probability eligible msci calculated age prefecture residence year probabilities matched children health data comprehensive survey living conditions results show eligibility msci improves subjective measures health status among preschool children however find improvement among school age children addition msci eligibility reduce hospitalization among either preschool school age children taken together study finds discernible effects health among school age children suggesting recent rapid expansions msci age group associated improvement health status elsevier ltd rights reserved
combined actual situation material forming control engineering east china jiaotong university starting aims thinking construction comprehensive reform specialty paper analyze practice construction process material forming control engineering specialty construction specialty include enhancing building teaching staff learning course teaching materials experimental base engineering training base
background study impact psoriasis features associated psoriasis classification outcome population based follow cohort children juvenile idiopathic arthritis jia methods children jia followed median years prospective nordic population based cohort study data remission available children presence psoriasis psoriasis like rash dactylitis nail pitting enthesitis tenosynovitis heredity assessed relation ilar classification remission results clinical findings associated psoriasis developed consecutively year period six children psoriasis classified juvenile psoriatic arthritis according ilar criteria year follow dactylitis common children early onset jia years found cumulative median number eleven arthritic joints children psoriasis psoriasis like rash compared six rest cohort also chance remission years increased significantly patients psoriasis psoriasis like rash least two first degree heredity psoriasis psoriatic arthritis dactylitis nail pitting compared rest group conclusions results indicate severe disease time psoriasis associated jia features psoriasis develop disease course group major challenge encompass future jia classification order facilitate early tailored treatment
human dental tissue hydrated biological mineral composite terms volume mass human tooth mainly consists dentine enamel human dental tissues hierarchical structure versatile mechanical properties dentine enamel junction dej important biological interface provides durable bond enamel dentine life long success story intact free disease interface fail despite harsh thermo mechanical loading oral cavity underlying reasons remarkable strength durability still fully clear structural mechanical perspectives one possibility example residual stress engineering evolution led formation layer inelastic strain adjacent dej odontogenesis tooth formation however due significant experimental interpretational challenges meaningful quantification residual stress vicinity dej appropriate spatial resolution reported date study applied recently developed flexible versatile method measuring residual elastic strain sub micron scale utilising focused ion beam fib milling digital image correlation dic report results span transition human dentine enamel incorporate material lying vicinity dej capability observing association internal architecture residual elastic strain state micrometre scale useful understanding remarkable performance dej may help creation improved biomimetic materials clinical engineering applications statement significance studied micronscale residual stresses exist within human teeth enamel outer tooth shell hardest substance human body dentine soft bonelike vascularised tooth core dentine enamel junction dej extremely interesting example nature design terms hierarchical structuring residual stress management key developments reported systematic focused ion beam fib milling digital image correlation dic micrometre scale residual strain evaluation determination principal strain direction near dej correlated internal architecture responsible remarkable strength work helps understanding dej performance improying biomimetic materials design clinical engineering applications acta materialia inc published elsevier ltd rights reserved
study develops novel cervical precancerous detection system using texture analysis field emission scanning electron microscopy sem images processing scheme adopted proposed system focused two steps first step enhance cervical cell sem images order show precancerous characterization indicator problem arises question extract features characterize cervical precancerous cells first step preprocessing technique called intensity transformation morphological operation itmo algorithm used enhance quality images proposed algorithm consisted contrast stretching morphological opening operations second step characterize cervical cells three classes namely normal low grade intra epithelial squamous lesion lsil high grade intra epithelial squamous lesion hsil differentiate normal precancerous cells cervical cell sem images human papillomavirus hpv contained surface cells used indicators paper investigated use texture tool determining precancerous cell images based observation cell images distinct visual texture gray level occurrences matrix glcm technique used extract texture features confirm systems performance system tested using cervical cell sem images results showed accuracy sensitivity specificity proposed system respectively
purpose goal study compare international prostate symptom storage subscore ipss active bladder symptom score oabss tools assessing symptoms overactive bladder oab methods cross sectional study conducted sample patients aged years older lower urinary tract complaints undergone medical examination one several centers patient reviewed international prostate symptom score oabss patients divided groups according ipss result group score group score another groups according oabss diagnosis group oab patients group non oab patients determined whether oabss varied statistically significant extent groups furthermore evaluated correlation ipss severity oabss results group oab diagnosis rate compared groups results groups oabss results found vary statistically significant extent group significant correlation found ipss severity oabss results prevalence analysis statistically significant difference found among groups receiver operating characteristic curve showed area curve conclusions results cross sectional analysis suggest ipss oabss significantly correlated although scores used measure oab symptoms simultaneous use ipss oabss warranted
introduction cardiovascular morbidity mortality increasing concern patients also health care profession service providers preventative benefit treatment dyslipidaemia unquestioned large far unmet need improve clinical outcome exciting new discoveries targets may translate improved clinical outcome areas covered review highlights new pathways cholesterol triglyceride metabolism examines new targets new drugs new molecules review includes results recent trials relatively new drugs shown benefit cardiovascular endpoint outcomes drugs licenced without endpoint trials yet available new drugs yet licenced produced exciting results animal studies early phase human studies expert opinion new areas discovered cause dyslipidaemia opened host new targets new drugs including antisense rna microrna human monoclonal antibodies plethora new targets new drugs made extraordinarily exciting time development therapeutics combat atherosclerosis
emergence drug resistant viruses high cost adverse side effects associated standard therapy hepatitis virus hcv infection demonstrate need development well tolerated effective antivirals identified chemically characterised dehydrorotenoid boeravinone isolated herb boerhaviadiffusa new inhibitor hcv entry compound significantly inhibits binding entry hepatitis like particles hcv lps hepatoma cells invitro apparent cytotoxicity boeravinone inhibits initial phase hcv entry probably acting directly viral particle importantly compound prevents hcv entry infection cell culture exvivo thus boeravinone potential antiviral agent prevention control hcv infection
background objectivethe aim study evaluate effect nonsurgical periodontal therapy clinical parameters gingival crevicular fluid levels tissue blood vessel type plasminogen activator plasminogen activator inhibitor pai patients periodontitis without rheumatoid arthritis material methodsfifteen patients chronic periodontitis systemically healthy patients chronic periodontitis periodontally systemically healthy volunteers included study plaque index gingival index probing pocket depth clinical attachment level bleeding probing gingival crevicular fluid pai levels erythrocyte sedimentation rate serum reactive protein disease activity score evaluated baseline mechanical nonsurgical periodontal therapy resultsall periodontal clinical parameters significantly higher groups compared group decreased significantly treatment pretreatment levels highest group significantly decreased post treatment pre post treatment pai levels significantly lower controls compared periodontitis groups gingival crevicular fluid volume levels pai significantly correlated conclusionin patients periodontitis nonsurgical periodontal therapy reduced pretreatment gingival crevicular fluid levels significantly correlated gingival crevicular fluid pai levels significantly higher pai gingival crevicular fluid levels periodontal patients regardless systemic status suggest plasminogen activating system plays role disease process periodontitis
type diabetes mellitus alzheimer disease two common diseases aging around world given frequency occur notion people may increased risk large societal consequences understanding mechanistic links diseases imperative development effective prevention treatment strategies apart accelerator associated progressive cognitive decline impaired insulin signaling inflammation accumulation advanced glycation end products oxidative stress play essential role pathogenesis diabetic complications therefore reasonable postulate pathways involved increased risk dementia occurs population early diagnosis cognitive impairment identification subset patients higher risk developing challenge healthcare providers meeting permit implement personalized medicine essential issue diabetes care significant therapeutic implications main gaps filled achieve objective examined
thermodynamic feasibilities four possible intermediates atoms two compounds oxychlorides carbochlorination process alo feo sio fly ash evaluated thermodynamic simulation using factsage software atmosphere pressure atm temperature range formation intermediates reaction routes carbochlorination process revealed
discrete conformal mappings planar triangle meshes also known similar possible asap mapping involve minimization quadratic energy function thus easy generate popular image warping scenarios generalize classical mapping case quad meshes taking account mapping interior quad analyze detail common case unit grid mesh show generalization combined barycentric coordinate mappings source target polygons spawns entire family new mappings governed quadratic energy functions allow control quite precisely various effects mapping approach quite general applies also arbitrary planar polygon meshes application generalized asap mappings unit grid mesh demonstrate used warp digital photographs achieve variety effects one effect modifying perspective camera took given photograph without moving camera related challenging effect photography warping contemporary photograph order reproduce camera view present vintage photograph scene taken many years different camera different viewpoint apply generalized asap mapping images discretized unit grid using quad mesh opposed triangle mesh permits biasing towards affine maps unit squares allows introduction affine possible aaap mapping good approximation homographies present warps achieving quite accurate results demonstrate advantages aaap mapping variety synthetic real world examples
computational thinking core computer science field essential thinking process solve problems effectively efficiently using computing systems learners must able design algorithms identify appropriate algorithm design skill specific problem apply problem aiming stimulate learners interest learning algorithm design skills developed puzzle based algorithm learning program user friendly format tailored real world scenario investigated effect puzzle based algorithm learning program learners abilities results provide evidence puzzle based algorithm learning program effective developing learners study suggests puzzle based algorithm learning worth learning model improving learners
background western countries quarter children affected parental separation number authors previously investigated familial structure impacts children health purpose work analyze psychomotor development children aged months based family structure parents together separated independently influence socio economic environment well documented analyse psychomotor development children younger years based family structure parents together separated independently influence socio economic environment well documented methods cross sectional study examination children part free preventive medicine consultation data came assessment conducted months birth information collected psychomotor development perform standing jump dress draw vertical line circle use pronoun build three word sentence say first name results ten percent children separated parents compared parents together adjusting socioeconomic environment well potential confounders adjusted odds ratios ors confidence interval children separated parents terms ability perform standing jump dress draw vertical line circle respectively adjusted ors children inability say pronoun build three word sentence say first name respectively conclusions adjusting sociocultural factors potential confounders observed children exhibited slower progression psychomotor development especially language graphic abilities parents separated implications study somewhat limited provide necessary arguments enabling set prospective cohort study study able better assess impact parental separation child development confirming preliminary results
integrating culture sustainable development ongoing research topic yet interest green building community existing green building programs including standards certification auditing schemes focus technical assessment assuming building cultural resource reflects past shapes future society added cultural sustainability green buildings recognizing three roles cultural proposed cost action cultural sustainability culture fourth dimension safeguarded culture mediating balancing factor dimensions culture essential foundation achieve proposed cultural sustainability criteria indicators framework adopted green building communities depth review relevant indicator systems ecosystem services sustainable regional urban planning existing green building programs copyright john wiley sons ltd erp environment
systematic review synthesised literature predictors moderators mediators outcome following fairburn cbt eating disorders sixty five articles included relationship individual variables outcome synthesised separately across diagnoses treatment format early change found consistent mediator better outcomes across eating disorders moderators mostly tested binge eating disorder moderators affect cognitive behavioural treatment outcome relative treatments consistent predictors emerged findings suggest unclear treatment works research testing mediators moderators needed variables selected analyses need empirically theoretically driven future recommendations include need authors interpret clinical statistical significance findings use consistent definition outcome studies directly compared iii report null statistically significant findings copyright john wiley sons ltd eating disorders association
attack angioedema frequently occurring disorder especially adults may appear without hives itch may idiopathic may accompany disorders may allergic including ige related histamine major mediator non ige related mediated mediators paf allergic angioedema provoked food insect venom drug allergic focal infection often itching hives corticosteroids antihistaminics adrenalin drugs effectively removing symptoms nonallergic angioedema contrast allergic one usually induced bradykinin type angioedema grows slowly accompanied itch hives reach large size disappears spontaneously days bradykinin mediated angioedema consequence hereditary acquired deficiency inhibitor hyperactivity agglutination factor xii appear also intake drugs decrease inactivation bradykinin resistant corticosteroids antihistaminic drugs adrenaline requires treatment inhibitor drugs inhibitor receptor bradykinin fresh frozen plasma bradykinin angioedema presents subcutaneous external angioedema submucosal membrane internal organs usually airways digestive system bradykinin angioedema airways may fatal requires immediate efficient medical treatment however bradykinin angioedema digestive system also may dangerous due shock provoked hypovolemy ache due intestine occlusion
neurobiological mechanisms underlie facial affect recognition deficits traumatic brain injury tbi yet identified using functional magnetic resonance imaging fmri study aims determine differences brain activation facial affect processing people tbi facial affect recognition impairments tbi relative people tbi healthy controls facial affect recognition impairments tbi respectively identify relationships neural activity facial affect recognition performance facial affect recognition screening task performed outside scanner used determine group classification tbi patients performed greater one standard deviation normal performance scores classified tbi tbi patients normal scores classified tbi fmri facial recognition paradigm performed within environment results participants reported tbi tbi fmri task tbi tbi groups scored significantly lower group blood oxygenation level dependent bold signals facial affect recognition compared baseline condition viewing scrambled face revealed lower neural activation right fusiform gyrus tbi group group right fusiform gyrus activity correlated accuracy facial affect recognition tasks within outside scanner decreased activity suggests facial affect recognition deficits tbi may result impaired holistic face processing future directions clinical implications discussed
sustainability research faces many challenges respective environmental urban regional contexts experiencing rapid changes unprecedented spatial granularity level involves growing massive data need spatial relationship detection faster pace spatial join fundamental method making data informative respect spatial relations dramatic growth data volumes led increased focus high performance large scale spatial join paper present spatial join spark sjs proposed high performance algorithm uses simple efficient uniform spatial grid partition datasets joins partitions built join transformation spark sjs utilizes distributed memory iterative computation spark introduces calculation evaluating model memory spatial repartition technology optimize initial partition evaluating calculation amount local join algorithms without disk access compare four memory spatial join algorithms sjs performance improvement based extensive experiments real world data conclude sjs outperforms spark mapreduce implementations earlier spatial join approaches study demonstrates promising leverage high performance computing large scale spatial join analysis availability large sized geo referenced datasets along high performance computing technology raise great opportunities sustainability research whether new trends data technology utilized help detect associated trends patterns human environment dynamics
approximately new york city smokers chinese russian speakers increase utilization smoking cessation services among populations department health mental hygiene developed linguistically culturally tailored outreach strategies promote enhance annual nicotine patch gum program online web applications chinese russian introduced input sought community develop russian language radio newspaper ads russian speaking liaison provided phone assisted online enrollment support chinese newspaper ads introduced cantonese mandarin speaking liaison hired provide enrollment support russian speakers chinese speakers enrolled program via web application russian speakers applied via web application assisted russian speaking liaison forty four chinese speakers applied online russian speakers applied via web application assisted russian speaking liaison eighty five chinese smokers applied online via web application seventy assisted chinese speaking liaison following implementation culturally tailored cessation support interventions ethnic russian smokers uptake cessation support increased tenfold chinese smokers uptake doubled although linguistically appropriate resources essential foundation reaching immigrant communities high smoking rates devising culturally tailored strategies increase quit rates critical programmatic success
year old autistic son jake declining rate peers developing pimples sudden height hormones right side body slumps like someone stroke right handed uses left hand knocked eyes parallel tracks slamming temple corner wooden post one eye looks straight ahead looks side optic nerves damaged damage self inflicted banging punching head since babyhood
semiconductor quantum dots qds interesting photocatalysts solar fuel production environmental pollution control however poor stability recombination probability photogenerated electron hole pairs prevented practical applications qds based photocatalysts herein demonstrated incorporation amorphous titania tio coatings cuins zns tio heterostructures cis zns tio gel markedly boost photocatalytic performance stability reduction promoted photocatalytic activity cis zns tio gel associated enhanced light absorption distinctive heterojunction imposed integration cis zns tio amorphous tio coatings drastically speed separation photogenerated electron hole pairs moreover physical protection photo corrosion inhibition functions receptors photogenerated holes cis zns qds arised amorphous tio coatings mainly responsible promoted photo stability cis zns tio gel cis zns tio gel retained initial activity cycle tests bared cis zns tio showed distinct reduction approximately original efficiency due photocorrosion weight loss obviously incorporation amorphous tio along bulk appearance gel realized enhanced photocatalytic performance favorable cycling stability strategy could extended qds based photocatalysts improving photocatalytic performance toward practical application elsevier rights reserved
present mapreduce computing model based hadoop framework gradually become famous distributed computing framework remarkable features scalability fault tolerance data security powerful ability however hadoop framework supports limited load balancing policies may result performance deterioration heterogeneous clusters additionally hadoop advanced dynamic load balancing mechanism enabling optimal performance dynamic environment paper presents sliding window based dynamic load balancing algorithm specially aims balancing load among heterogeneous nodes hadoop job processing presented algorithm evaluated simulated physical environments experimental results show performances terms efficiency hadoop cluster significantly improved copyright john wiley sons ltd
extreme temperature differences flat steel box girder cable stayed bridge studied firstly using long term measurement data collected structural health monitoring system installed runyang cable stayed bridge daily variations well seasonal ones measured temperature differences box girder cross section area summarized probability distribution models temperature differences established extreme temperature differences estimated return period years finally temperature difference models cross section area proposed bridge thermal design results show horizontal temperature differences top plate vertical temperature differences top plate bottom plate considerable positive negative temperature differences described weighted sum two weibull distributions maximum positive negative horizontal temperature differences top plate degrees degrees respectively maximum positive negative vertical temperature differences top plate bottom plate degrees degrees respectively bridge thermal design two vertical temperature difference models top plate bottom plate six horizontal temperature difference models top plate
present study examined moderating effect cigarette smoking status relation anxiety sensitivity fear expected negative consequences anxiety bodily sensations hazardous alcohol consumption sexual compulsivity suicidality series multiple hierarchical regressions used test proposed hypothesis among sample persons living hiv aids usa male age fifty seven percent participants reported past month smoking results indicated reported smoking higher anxiety sensitivity demonstrated highest rates hazardous alcohol use sexual compulsivity suicidality simple slope analyses indicated anxiety sensitivity associated higher rates hazardous alcohol use sexual compulsivity suicidality among individuals reported past month smoking among individuals smoke present results suggest smoking status moderates relation anxiety sensitivity hazardous alcohol use sexual compulsivity suicidality among persons living hiv aids data add growing literature suggesting smoking negative impact among persons living hiv aids extends beyond physical health problems variety clinically significant behavioral health sequelae
introduction date descriptions literature gynecologic sexual function evaluation female patients dermatomyositis polymyositis objective assess sexual function female patients patients methods monocentric cross sectional study patients ages years compared healthy women age group characteristics sexual function obtained applying questionnaires female sexual quotient fsq female sexual function index fsfi validated brazilian portuguese language results mean age patients comparable controls years well distribution ethnicity socioeconomic class gynecological characteristics patients healthy controls differ respect age menarche percentages dysmenorrhea menorrhagia premenstrual syndrome pain mid cycle mucocervical secretion vaginal discharge fsq score well domains fsfi questionnaire desire arousal lubrication orgasm satisfaction significantly decreased patients versus controls patients showing degree sexual dysfunction conclusions first study identify sexual dysfunction patients therefore multidisciplinary approach essential patients idiopathic inflammatory myopathies order provide prevention care sexual life providing better quality life patients partners elsevier editora ltda
accumulation ceramide implicated mediating cellular responses stress aberrant sphingolipid metabolism frequently associated metabolic neurodegenerative diseases often assumed peripheral disturbances sphingolipid concentrations reflective processes occurring brain circulating sphingolipids directly influence cerebral sphingolipid abundance order address assumptions study explores physiological system metabolic pathways regulating sphingolipid metabolism brain plasma mice male cbl maintained low fat control diet saturated fat enriched sfa diet without provision sphingolipid modulating agents following months feeding abundance seven sphingolipid classes assessed esi hippocampus hpf cerebral cortex ctx plasma long term consumption sfa diet increased ceramide dihydroceramide plasma inhibiting novo synthesis ameliorated effect inhibition acidic sphingomyelinase sphingosine phosphate receptor agonist sfa feeding influence sphingolipid levels either hpf ctx novo synthesis inhibition reduced ceramide ctx treatment sphingosine phosphate receptor agonist reduced ceramides hpf analysis individual ceramide species revealed effects chain length dependent positive negative correlations observed plasma hpf ctx ceramide species findings study show hpf ctx sphingolipid concentration influenced distinct pathways independent peripheral sphingolipid concentration
past decade development computer aided graphics field appliedgraphics rapid graphics system established based traditional ruler gauge conditions also changed dramatically therefore author reviewed current situation following pulse information times premise practice application making bold adjustment traditionaldesign graphics teaching environmental art design major introducing intelligent modeling technologyin teaching process making defect traditional graphics teaching space expression accordingly increase student computer graphics link order construct teaching system design graphicswhich fit information times
ultra low power signal processing essential part sensor nodes particularly emerging wearable sensors biomedical applications analog signal processing important role low power low voltage low frequency applications key drive decrease power consumption existing analog domain signal processing map signal processing approaches analog domain paper presents analog domain signal processing circuit approximates output discrete wavelet transform dwt use ultra low power wearable sensors analog filters used dwt filters demonstrated generate analog domain dwt like information embeds information butterworth daubechies maximally flat mother wavelet responses analog dwt realised hardware via gmc circuits designed operate coin cell battery provide dwt like signal processing using power implemented cmos process practical examples demonstrate effective use new analog dwt ecg electrocardiogram eeg electroencephalogram signals recorded humans
manufacturing cost analysis becoming increasingly important tool photovoltaics industry identify research areas need attention enable progress towards cost reduction targets describe method estimate manufacturing cost suitable use early stage technology development delivering manufacturing cost estimate well uncertainty analysis quickly highlights opportunities greatest cost improvement apply technique three process sequences large scale production organic inorganic hybrid perovskite photovoltaic modules process sequence combines two demonstrated perovskite module sequences estimated cost uncertainty range comparable commercial crystalline silicon cadmium telluride technologies basis levelized cost electricity calculation shows perovskite technology would competitive incumbent photovoltaic technologies module power conversion efficiency lifetime years achieved analysis shows even cost active layers rear electrode reduced zero module power conversion efficiency lifetime years would required meet sunshot levelized cost electricity targets copyright john wiley sons ltd
context fibroblast like synoviocytes fls rheumatoid arthritis display pathogenic behavior various members wnt pathway especially canonical wnt catenin cascade may contribute autonomous fls activation shown two wnt inhibitors sfrp dkk contribute several critical aspects joint biology however effects fls poorly characterized aim study investigate effects sfrp dkk fls markers wnt components target oncogenes expression fls compare findings osteoarthritic fls materials methods fls treated sfrp dkk days wnt signaling components wnta lrp catenin wnt target oncogenes cyclin wisp fls markers fibronectin mmp analyzed using western blotting qrt pcr results data indicated sfrp regulated key gene catenin fls sfrp decreased fibronectin well known downstream effectors gene wnt catenin pathway lrp expression fls fls sfrp induced increased expression wnta mmp affect levels fls hand dkk increased fibronectin expression fls decreased expression fls conclusion results confirm involvement wnt signaling fls transformation show two inhibitors cascade regulate differently elements single inhibitor initiate signaling depending cellular context abbreviations fls fibroblast like synoviocytes rheumatoid arthritis wnt wingless frizzled lrp low density lipoprotein receptor protein wisp wnt inducible signaling pathway protein sfrp secreted related proteins dkk dickkopf osteoarthritis dmem dulbecco modified eagle medium fbs fetal bovine serum pbs phosphate buffered saline sds page sodium dodecyl sulfate polyacrylamide gel electrophoresis ecl enhanced chemiluminescence detection solution mmp metaloproteinase qrt pcr quantitative real time polymerase chain reaction standard deviation crd cysteine rich domain mecp methyl cpg binding protein rankl nuclear factor kappa ligand
multiple sclerosis lesions influence process image analysis leading tissue segmentation problems biased morphometric estimates existing techniques try reduce bias filling lesions normal appearing white matter weighted images considering time point separately however due lesion segmentation errors presence structures adjacent lesions ventricles deep grey matter nuclei filling lesions white matter like intensities introduces errors artefacts paper present novel lesion filling strategy inspired painting techniques used computer graphics applications image completion proposed technique uses five dimensional patch based multi modality andmulti time point non local means algorithm fills lesions plausible texture demonstrate strategy introduces less bias fewer artefacts spurious edges current publicly available techniques proposed method modality agnostic applied multiple time points simultaneously addition preserves anatomical structures signal noise characteristics even lesions neighbouring grey matter cerebrospinal fluid avoids excess blurring rasterisation due choice segmentation plane shape lesions size location authors published elsevier inc
today manufacturers fully leverage potential computer aided engineering cae design machine tools production machines common design tools drive systems machine components build algebraic system description however dynamic quality criteria significant impact achievable accuracy productivity evaluated purely algebraic descriptions generally dynamic criteria incorporated signal oriented models control engineering modeling process time consuming knowledge intensive reusability models limited paper presents methodology simplify optimization machine components feed drives taking dynamic quality criteria account method based object component oriented modeling language modelica quick development models limited expert knowledge models integrated extensible model library modern mathematical optimization methods support systematic search combination system components parameters regards defined quality criteria therefore different design alternatives quickly analyzed compared authors published elsevier
antimicrobial resistance increases health social economic impact areas state regional local initiatives try contain problem resistance arise update year study microbiological epidemiological clinical aspects multi resistant bacteria well resources therapeutic approach ancient modern drugs therapeutic combinations optimization stewardship programs case fungal infection analyze clinical scenarios different species yeast new clinical settings filamentous fungi taking paediatric population homologies differences adults invasive fungal infection compared finally field parasitology treatment severe malaria imported resistant antimalarial drugs reviewed
background enhance indicated prevention patients clinical high risk chr psychosis recent research efforts increasingly directed towards estimating risk developing psychosis individual level using multivariable clinical prediction models aim study systematically review methodological quality reporting studies developing validating models method systematic literature search carried march find studies developed validated clinical prediction model predicting transition psychosis chr patients data extracted using comprehensive item list based current methodological recommendations results total studies met inclusion criteria none retrieved studies performed true external validation existing model three studies event per variable ratio least recommended minimum avoid overfitting internal validation performed studies seven used biased internal validation strategies frequently observed modeling approaches recommended methodologists included univariable screening candidate predictors stepwise variable selection categorization continuous variables poor handling reporting missing data conclusions systematic review revealed poor methods reporting widespread prediction psychosis research since studies relied small sample sizes perform internal external cross validation used poor model development strategies published models probably overfitted reported predictive accuracy likely overoptimistic
work crack initiation elliptical holes plates uniaxial tension studied means closed form analytical finite fracture mechanics approach allow detailed study crack initiation stress intensity factors available literature discussed compared extensive numerical results based physical rationale improved stress intensity factor solution proposed shows good agreement numerical results wide range stress concentration factors ellipse crack lengths using exact solution stress field notched plate proposed stress intensity factor efficient finite fracture mechanics solution obtained empiric length parameters introduced strength fracture toughness required evaluation analysis comprises case circular hole limiting cases crack tangential normal loading direction typical notch size effects covered coupled stress energy approach continuous transition strength materials linear elastic fracture mechanics rendered elsevier masson sas rights reserved
mediterranean mussel mytilus galloprovincialis species bivalve mollusk high capacity filtering water nearby concentrate virus bacteria present constitute microbiological risk consumed afterwards thus depending water pollution mussels suffer depuration process usually controlled using escherichia coli indicator aim study determine microbiological quality mussels various sources purifying consider utility use clostridium perfringens quality indicator microbiological analysis performed fifteen lots mussel samples obtained spain italy aerobic mesophilic microorganisms enterobacteriaceae coli vibrio spp listeria monocytogenes perfringens presence salmonella spp measured results showed presence salmonella spp four batches mussels various locations perfringrens thirteen samples within legal limits coli conclusion results propose use coli indicator microorganism mussels depuration process sufficient assure microbiological quality product thus would appropriate include perfringens additional indicator control carried refinement done finally results emphasized necessity properly cook food product prior consumption allows destruction microorganisms present
background risks early growth becoming overweight adulthood widely studied humans however early life predictive factors canine adult overweight obesity yet studied identify factors may help explain development overweight obesity adulthood dogs longitudinal study years conducted female beagle dogs age sexual status raised identical environmental conditions means hierarchical classification principal components following quantitative values fat free mass ffm percentage fat mass pelvic circumference years age three groups dogs established nominally named ideal weight slightly overweight overweight aim identifying predictive factors development obesity adulthood parental characteristics growth pattern energy balance plasma factors analysed logistic regression analysis results months group compositions line body condition scores bcs values groups logistic regression analysis permitted identification neonatal growth rate first weeks life bcs months predictors development obesity adulthood seventy percent dogs either grw bcs months belonged group results energy intake expenditure corrected ffm showed greater positive energy imbalance months compared group conclusion study expands understanding previously reported risk factors overweight obese dogs establishing studied dogs became overweight bcs months age could used predictive factors overweight adult dogs group higher values compared groups dogs
phylogenies getting easier build difficult reuse combine synthesize information provide published trees often available image files taxonomic information standardized across studies open tree life otl project addresses issues providing digital tree encompasses organisms built combining taxonomic information published phylogenies project also provides tools services query download parts synthetic tree well source data used build present rot package search download data fromthe open tree life directly rot uses common data structures allowing researchers take advantage rich set tools methods available manipulate analyse visualize phylogenies vignettes accompanying package demonstrate rot used packages analyse biodiversity data phylogenies used growing number applications rot facilitates access phylogenetic data allows integration statistical methods data sources available inr
wind turbine drivetrains consist components directly convert kinetic energy wind electrical energy therefore guaranteeing robust reliable drivetrain designs important prevent turbine downtime current drivetrain models often lack ability model impacts electrical transients well wind turbulence shear one package paper capability fast wind turbine computer aided engineering tool developed national renewable energy laboratory enhanced integration dynamic model drivetrain dynamic drivetrain model built using simscape matlab simulink environment incorporates detailed electrical generator models model used evaluate internal drivetrain loads due excitations wind generator
despite persistence wage gaps indicators discrimination many americans oppose affirmative action women study investigated potential source social influence often hypothesized reduce compassion sympathy women pornography national panel data employed data gathered adults ranging age baseline pornography viewing indexed via reported consumption pornographic movies attitudes toward affirmative action indexed via opposition hiring promotion practices favor women contrary selective exposure perspective media use prior opposition affirmative action predict subsequent pornography viewing consistent social learning perspective media effects prior pornography viewing predicted subsequent opposition affirmative action even controlling prior affirmative action attitudes number potential confounds gender moderate association practically results suggest pornography may social influence undermines support affirmative action programs women theoretically results align perspective sexual media activate abstract scripts social behavior may applied judgments extend beyond specific interaction patterns depicted
study aim construct significant structural measurement model comparing students affective characteristics mathematic achievement according model aim test measurement invariances gender sub groups hierarchically study conducted basic descriptive research secondary level analyses conducted program international student assessment pisa turkish student questionnaire data sample consisted fifteen year old students schools statistical territories analysis techniques regression analysis exploratory confirmatory factor analyses executed order construct significant initial measurement model multi group confirmatory factor analysis executed analyse invariance gender sub groups according results taking consideration limitations model constructed study observed strong invariance gender sub groups provided finding indicates similarities affective characteristics fifteen year old turkish students across gender sub groups results evaluated evidence possibility bias prejudice students affective characteristics toward mathematics high
degradation membranes proton exchange fuel cells chemical oxidation one main factors limiting lifetime effect electric field oxidative degradation poly phenylene bibenzimidazole pbi investigated using electro fenton tests degraded pbi characterized measuring sample intrinsic viscosity eta int weight loss using thermal gravimetric analysis tga scanning electron microscopy sem fourier transform infrared spectroscopy ftir nuclear magnetic resonance spectroscopy nmr ray photoelectron spectroscopy xps intensity electric field increased membrane weight decreased eta int pbi decreased rapidly meanwhile larger number larger pores formed pbi membranes according sem images thermal stabilities degraded pbi membranes decreased significantly intensity electric field increased ftir nmr xps spectra revealed electric field accelerated formation amide amino groups breakdown benzimidazole rings pbi amino groups stabilized protonation acidic fenton reagent possible mechanism increased oxidative degradation pbi electric field proposed elsevier ltd rights reserved
potential influence violent video games youth violence remains issue concern psychologists policymakers general public although several prospective studies video game violence effects conducted none employed well validated measures youth violence considered video game violence effects context influences youth violence family environment peer delinquency depressive symptoms current study builds upon previous research sample female mostly hispanic youth results indicated current levels depressive symptoms strong predictor serious aggression violence across outcome measures depressive symptoms also interacted antisocial traits antisocial individuals depressive symptoms inclined toward youth violence neither video game violence exposure television violence exposure prospective predictors serious acts youth aggression violence results put context criminological data serious acts violence among youth
field remote laboratories developed years laboratories valuable educational tools allow students faculty interact real equipment internet physically front system remote laboratory developed many technical difficulties found mainly respect links different elements physical system database clients work analyze challenges propose approaches develop remote laboratories achieve flexibility scalability greater educational value particular present remote laboratory automatic control includes electro pneumatic classification cell architecture laboratory based three tier architecture physical system layer server layer client layer client layer implemented web standards html ajax css clients interact system using content management system communication interface physical system database uses middleware based opc ole process control engineering students regularly used remote laboratory evaluated surveys elsevier ltd rights reserved
present work report results spin trapping esr study four essential oils widely used skin care products creams bath salts studied essential oils rosmarini aetheroleum rosemary menthae piperitae aetheroleum mint lavandulae aetheroleum lavender thymi aetheroleum thyme fenton reaction presence ethanol used generate free radicals tert butyl alpha phenylnitrone pbn used spin trap fenton reaction rosemary oil lowest effect radical adduct formation compared reference fenton system since essential oils known lipid soluble also conducted studies essential oils fenton reaction presence lipids two model lipids used namely dioleoyl glycero phosphocholine dopc dipalmitoyl glycero phosphocholine dppc obtained results suggested presence dopc lipids center dot pbn chch center dot radicals formed phases water lipids studied essential oils affected fenton reaction similar way whereas dppc system additional type pbn radical adduct generated dft calculations hyperfine splittings performed blyp epr level theory set centered pbn adducts order identify pbn radical
depletion global ipv address pool made deployment ipv new version internet protocol inevitable paper transition mechanisms first phase ipv deployment surveyed dns plus nat solution found appropriate important free open source dns implementations selected bind totd unbound powerdns test environment testing method described first three selected dns implementations tested linux openbsd freebsd whereas powerdns tested linux performance characteristics response time number answered requests per second cpu memory consumption measured compared effect hardware architecture test computer also examined using single core dual core quad core test computers stability tested dns solutions analyzed overload conditions test may used production environments strong response time requirements measurement results show significant differences performance tested dns implementations unbound served four times requests per second powerdns executed single core cpu linux load generated eight clients however absolute order determined influenced different factors architecture hardware especially number cores bind powerdns multithreaded therefore profit multiple cores totd unbound also operating system dns server significant influence performance dns implementations certain conditions details measurements disclosed results presented paper easy use implementation selection guide also provided short summary high number results
evidence indicates green buildings outperform conventional non green buildings many performance areas nevertheless perceived higher upfront cost building owners investors frequently cited hurdle widespread adoption green buildings study extensive literature survey conducted aggregate green cost premiums reported results published empirical studies investigated cost premium associated green building results methodologies empirical studies tabulated comparatively analyzed find conclusive answer whether green building costs less conventional counterpart yet consensus reached significant gap exists quantified cost premium range reported green cost premiums empirical investigations fall within range two studies found green buildings cost less conventional counterparts surprisingly among reviewed empirical studies six publications classified academic publications four research articles published peer reviewed journals one conference paper one book size literature addresses issue green buildings cost premium reflect significance problem elsevier rights reserved
paper presents detailed approach provide improved cooling heat spreading electric machine rotors using centrifugally pumped revolving thermosiphons design concepts discussed offer following advantages high thermal performance across wide range operating points low impedance heat paths excellent opportunities integration electric machine design improved electromagnetic performance structural design well practical cost effective manufacturing takes advantage centrifugal force provide effective inertial pumping wide range operating conditions addition new thermosiphon design compatible existing standard electric machine manufacturing techniques cooling needs condenser section fin ramp structure provides consistently high condensation performance surface texture design promote effective nucleate boiling high speeds discussed fluid fill factor analyzed applications include induction synchronous machines benefits thermosiphons include increased steady state power torque density increased consistent efficiency reduced permanent magnet volume cost synchronous machines applications may include centrifugal gas compression chemical processes machine tools
covering generalized rough set theory important extension classical rough set theory characterize fuzzy set given covering approximation space pair fuzzy sets called covering rough fuzzy lower upper approximations introduced describe well much uncertainty induced granularity knowledge paper first discuss relationship uncertainty granularity knowledge examine several commonly used distance measures indicate exhibit limitations next propose roughness measure based minkowski distance examine important properties measure finally illustrative example provided demonstrate application roughness measure incomplete information systems fuzzy decision
integration digital technologies institutions higher education profoundly influencing formal learning global scale social constructivist models fully online learning well positioned address demands government economic social development organizations civically engaged individuals strong problem solving critical thinking collaboration competencies established record performance university ontario institute technology uoit canada fully online learning community folc one model paper theorizes folc response several problematics including aforementioned demand greater educational focus higher order competency development deficiencies distance education moocs learning models quest new learning models strengthen deliberation skills deepen democratic experience divergent fork community inquiry model folc describes collaborative learning symbiosis social cognitive interactions amplified effective use synchronous asynchronous digital affordances furthermore models democratized learning communities reduce transactional distance learners educators incorporates authentic assessment encourages negotiated technology affordances cognitive outcomes distributing responsibility constructive criticality positioned folc conceptually addressed current limitations research agenda extending empirical foundations leveraging uoit eilab affordances presented underlying argument self regulating transformative learning communities established sustained fully online environments communities produce diversity beneficial learning outcomes deepen democratic functioning learners social contexts
purpose study examine youth perceptions attention deficit hyperactivity disorder adhd communication pediatric providers reported adherence adhd medications desired location adhd educational program youth ages adhd diagnosis recruited research associate interviewed youth parents completed demographic questionnaires seventy families participated one third youth wanted discussion adhd providers visits average youth eight questions adhd treatment youth wanted learn adhd provider office non white older youth significantly likely less adherent adhd medications youth want providers engage visits providers take advantage interest engage youth discussions regarding adhd treatment pediatric adhd visits
widely publicized violent encounters police african american youth unknown consequences emotional mental health pregnant african american women since studies document hypervigilance black mothers exert protect children violence racism findings also reveal association racial gendered stress includes parenting stressors depressive symptoms pregnancy examination effects stress anticipated negative experiences black youth police maternal mental health warranted july august mostly low income pregnant african american women lived metropolitan atlanta first second trimesters completed edinburgh postnatal depression scale selected items jackson hogue phillips contextualized stress measure demographic form bivariate logistic regression analyses conducted response questions asked anticipation negative encounters black youth police associated antenatal depressive symptoms presence prior children male female contribute association question results showed anticipated negative african american youth police experiences significantly associated antenatal depressive symptoms chi question presence preschool aged male child home significantly associated antenatal depression odds ratio observed associations antenatal depressive symptoms anticipated negative police youth encounters implications clinical community based interventions responding unique psychosocial risks pregnant african american women
rainwater harvesting alternative sources water supply used potable non potable uses could helps store treated rainwater beneficial use also flood mitigation sustainable approach flooding problem reduction urban areas slowing rate surface runoff flows source providing storage area tank order understand performance rainwater harvesting system rwh preliminary monitoring diy rwh model additional first flush strategy water quality treatment done main concept behind first flush diversion prevent initial polluted rainwater entering storage tank based seven rainfall events observed parit raja quality quantity rainfalls analysed rainwater quality samples first flush diverter storage tank taken understand performance based dissolved oxygen turbidity total dissolved solid tds total suspended solid tss chemical oxygen demand cod biochemical oxygen demand bod parameters rainwater quantity hydrograph analysis done based performance total rainfall runoff peak flow rainfall runoff delayed time parameters based interim national water quality standard inwqs national drinking water quality standard ndwqs first flush diverter apparently helps water quality improvement storage tanks tds tss turbidity classified class inwqs allowable drinking bod cod parameters classified class iii inwqs hence potential used potable usage need extensive treatment reduce poor microbial quality based maximum observed rainfall event total volume liter peakflow reduction delayed runoff minutes rainfall started concludes performance water retention could due total rainfall tank capacity therefore rwh potential used potable use time also potential reduce local urban flooding
combining photorefractive spatial soliton waveguide sbn crystal coherent system able manipulate spatial frequencies input optical image perform edge enhancement direct component enhancement operations theoretical analysis optical image processor presented interpret experimental observations work provides approach optical image processing using photorefractive spatial solitons elsevier rights reserved
recently mobile applications emerged uprising smartphone trend days huge number mobile operating systems require developments order achieve open source cross platform mobile frameworks came order allow importing code various operating systems paper focus made commonly used mobile development methods process selects suitable solution particular need proposed eventually new framework helps choose appropriate approach tool respectively suggested according convenient survey based binary questions addition certain criteria
electricity customers install solar panels often paid prevailing retail price electricity generate demonstrate rate compensation typically optimal payment distributed generation retail price electricity often induce welfare maximizing level distributed generation fixed costs centralized electricity production network management costs accommodating intermittent solar large centralized generation produce similar pollution externalities optimally exceed alternative conditions optimal compensation policy varies considerably industry conditions change furthermore requirement equate reduce aggregate welfare substantially generate pronounced distributional effects
single institution retrospective experience examining effect race ethnicity disease phenotype myeloproliferative neoplasms demonstrate racial disparities outcomes myeloproliferative neoplasm caucasian ethnicities relatively protected cardiovascular thrombosisis hemorrhagic complications african americans ethnic sub group highest risk hemorrhagic complications background philadelphia chromosome negative myeloproliferative neoplasms mpns characterized increased risk thrombotic hemorrhagic complications large retrospective studies demonstrated racial disparities mpn outcomes attributed differences access health care utilizing single institution experience report outcomes patients polycythemia vera essential thrombocythemia myelofibrosis relation ethno racial background patients methods total caucasian non caucasian adult patients mpns consecutively treated university illinois examined retrospective study relationships ethno racial background vascular complications disease transformation evaluated using multivariate logistic regression models results non caucasian patients increased risk vascular complications including cardiovascular thrombosis hemorrhagic events caucasian patients higher risk progression myelofibrosis cox proportional hazard regression analysis caucasian race emerged independent prognostic factor protective cardiovascular thrombosis patients hazard ratio confidence interval age years prior thrombosis significant risk factors univariate analysis non caucasian race also significant risk factor univariate analysis hemorrhagic complications largely driven african american ethnicity conclusion study shows first time race influence clinical outcomes myeloproliferative neoplasms findings highlight need greater representation non caucasian patients studies investigating vascular risk factors mpns elsevier inc rights reserved
introduction children affected nutritional eating disorders adults bipolar disorder display symptoms deficient emotional self regulation present different forms observe clinical developmental histories individuals affected eds based cognitive systemic post rationalist approach hypothesise continuum two disorders aim pilot study support hypothesis explanatory rather non descriptive approach eds possible result issues tied biological psychological self regulation issue manifests individual early stages eating disorder likely result actual affective disorder individual adult years materials methods study examined total patients affected ages least one parents diagnosed mental disorder subjects completed child behavior checklist cbcl eating disorders inventory edi patients underwent pediatric assessment using bmi establish type parents divided two groups subjects subjects affected psychopathologies results although comparison patients eds parents without demonstrate significant difference scale highlighted specific common characteristics disorder presented parent cognitive emotional expressions child fact results indicate cbcl problems thought scale explains much impulsivity variance obtained edi cbcl high withdrawal depression dependent factor highlighted statistical significance edi low interoceptive awareness scale conclusions study presented limitations especially respect sample size examined suggests field explored understand reasons significance aspects related contrasting emotional adjustments impulsivity depression withdrawal highlighting connection parents distinctive relational model
human health beset legion ailments exacerbated lifestyle errors numerous enzymes human body aromatase tytochrome enzyme particularly critical occurring crossroads multiple signalling pathways homebstasis vital optimal health unfortunately medications hormone therapy chemical additives food endocrine disrupting personal care products oscillating aromatase concentration beyond permissible level enzyme converts androgens estrogens agitation different outcomes different genders age groups common pathologies associated aromatase disruption include breast cancer prostate cancer polycystic ovary syndrome pcos endometriosis osteoporosis ovarian cancer gastric cancer pituitary cancer alzheimer disease schizophrenia male hypogonadism transgender issues several drugs cosmetics pesticides act activators suppressors enzyme carefully compiled critical review expected increase public awareness regarding threats resultant perturbations enzyme motivate researchers investigation field elsevier ltd rights reserved
nuclear envelope amazing piece engineering one hand built like mediaeval fortress filament systems reinforcing membrane walls double membrane structure forming lumen like castle moat hand structure adapt maintaining integrity like reed bending river like fortress guarded drawbridges nuclear pore complexes also mechanical means communication enabled largely linc complex multi protein structure connects intermediate filament nucleoskeleton across lumen double membrane nuclear envelope multiple cytoplasmic filament systems could act simultaneously like mediaeval buttresses like lines suspension bridge although many details greater linc structure remain discerned number recent findings giving clues structural organization yield striking dynamic yet stable properties combining double triple helical coiled coils intrinsic disorder order tissue specific components intermediate filaments enables unique properties federation european biochemical societies published elsevier rights reserved
study examined infants early visual attention month age social engagement months predictors later joint attention months sample drawn maternal lifestyle study longitudinal multicenter project conducted centers national institute child health human development neonatal research network included high risk cocaine exposed matched noncocaine exposed infants hierarchical regressions revealed infants attention orienting month significantly predicted frequent initiating joint attention months age social engagement months predicted initiating joint attention months results provide first empirical evidence role visual attention social engagement behaviors developmental precursors later joint attention outcome
several challenges found current applications building information modelling model bim technology large scale mechanical electrical plumbing mep projects huge modelling workloads mep models details untapped potential supporting cooperative construction management multiple participants insufficient functions intelligent facility management paper proposes multi scale solution address insufficiencies current applications construction facility management mep projects particularly practical multi scale bim consisting several macro micro schematic scale information models described detail required information mep components according schema industrial foundation classes based model paper presents bim based construction management system provide virtual construction scenes appropriate scales various participants communicate cooperate well bim based facility management system share information delivered previous phases improve efficiency safety mep management operation maintenance period application real world airport terminal illustrates proposed model two systems support collaborative construction management facility management multi scale functionalities among participants paper proposes series feasible models techniques promote bim application large mep projects elsevier ltd rights reserved
recent years physical continuous decline students main strategy school sports work struggling facing degradation desalination weakening marginalized deformity development makes school physical education made way long time absence abdicated status state stage better way solve aftermath sports injury accident school physical education implement moderate basic cancelled kinds fierce confrontation physical contact may cause sports injuries sports teaching safety norms regulate activities parties reduce accidents effectively
cesarean birth recognized physical psychological stressor many women maternity practices cesarean birth meet women needs maintaining safety optimize experience family centered cesarean birth package interventions encourages woman participate choosing interventions would helpful undergoing planned unplanned cesarean birth included family centered cesarean birth implementation skin skin care operating room neonates appear term healthy process attempting implement family centered cesarean birth one academic center presented including steps implementation benefits challenges areas continued improvement research article part special series articles address midwifery innovations clinical practice education interprofessional collaboration health policy global health american college nurse midwives
non adherence treatment medical recommendations one leading causes treatment failure poor clinical outcomes increased healthcare utilization although non adherence observed across medical specialties adherence treatment dermatology deserves special attention given multiple different routes treatment adherence measured using subjective methods patient reporting questionnaires objective methods pill counts electronic chips pharmacy records adherence dermatologic treatments varies based specific condition poor systemic therapies even worse topical agents among factors influence adherence duration treatment complexity regimen access play large role interventions improve adherence range simplifying treatment regimens scheduling frequent office visits due profound effect cost healthcare outcomes mortality understanding improving adherence equally important making correct diagnosis prescribing correct treatment
article focused control houses flats apartments use currently popular smart wiring control system based programmable logical controller plc possibilities control heating lighting controlled access security air condition system present unusual possibilities also television satellite radio multimedia control via infra red modules technology last goal create describe user friendly web application whole house monitoring control via tablet mobile phone computer
severe health shocks provide new information one personal health shown influence smoking behaviors paper suggest may also convey information hard predict financial consequences illnesses relevant financial risk information idiosyncratic unavailable consumer preceding illness information search costs high however new salient information health well financial consequences smoking health shock may impact smoking responses using variation timing health shocks two features health care system uninsured spells aging medicare program test heterogeneity post shock smoking decision according plausibly exogenous changes financial risk exposure medical spending also explore relationship smoking evolution pocket costs individuals experiencing cardiovascular health shock uninsured spell twice cessation effect receiving illness insured uninsured prior age years experiencing cardiovascular shock post medicare eligibility completely offsets cessation effect also find older adults medical spending changes separate health shocks influence smoking behavior copyright john wiley sons ltd
many practical applications found control engineering functionality safety overall control process rely proper function respective operating system fact makes software one safety critical elements practical applications especially control process placed inhospitable environment directly accessible man one environments space paper problem designing safety critical real time operating system small space satellite called cubesat discussed shown design operating system increase reliability protect single upset events
backgroundexcessive gestational weight gain gwg associated adverse maternal child health outcomes managing energy intake gwg versus optimising nutrient intake challenging present study aimed examine relationships dietary portion size gwg nutrient intakes pregnancy hypothesised adjustment potential confounders portion size would positively associated gwg nutrient intakes pregnancy methodsprospective data obtained australian women women children health study validated food frequency questionnaire used weeks gestation quantify diet portion size previous months pregnancy nutrient intakes compared australian nutrient reference values nrvs gwg measured weeks compared institute medicine weight gain recommendations wtadh resultsin multivariate regression models portion size factor psf positively associated gwg women high socio economic status ses overweight obese pre pregnancy body mass index bmi psf uniquely accounted variability gwg women high ses overweight obese pre pregnancy bmis respectively nutrient intakes psf similar regardless wtadh women achieved nrvs calcium zinc psf categories women large psf still failed achieve nrvs folate iron fibre conclusionsall women require advice quality food choices pregnancy optimise health outcomes targeting portion size alone insufficient manage gwg may prove valuable tool pregnant women high ses overweight obese pre pregnancy
direct eye contact powerful social cue regulate interpersonal interactions previous behavioral studies showed link eye contact motor mimicry indicating automatic mimicry observed hand movements significantly enhanced direct eye contact exists observer observed model present study aim investigate neurophysiological basis previously reported behavioral enhancements transcranial magnetic stimulation tms applied assess changes cortico motor excitability level primary motor cortex explore whether motor system facilitated observing others hand movements particular process modulated eye contact motor evoked potentials meps collected two hand muscles participants received single pulse tms naturally observed video clips actor showing hand opening movements static hands observation either direct averted eye gaze established subject observed actor findings show clear effect eye gaze observation induced motor facilitation indicates mapping mirroring others movements significantly enhanced movement observation accompanied direct eye gaze compared averted eye gaze results support notion eye contact powerful social signal ability direct human non verbal social behavior furthermore findings important understanding role mirror motor system mapping socially relevant actions
scaling aggressive intermittent faults increasing importance current deep submicron complementary metal oxide semiconductor cmos technologies work shows dependability assessment fault tolerant computer system intermittent faults applied methodology lies vhdl based fault injection allows assessment early design phases together high level observability controllability evaluated system duplex microcontroller system cold stand sparing wide set intermittent fault models injected simulation traces coverages latencies measured markov models system generated dependability functions reliability safety calculated results enhancements detection recovery mechanisms suggested methodology presented general fault tolerant computer system
background aims vedolizumab gut selective alpha beta integrin antagonist therapy ulcerative colitis crohn disease gemini long term safety lts trial ongoing open label study investigating safety vedolizumab present interim exploratory analyses efficacy patients crohn disease methods patients gemini gemini studies vedolizumab naive patients could enrol gemini lts received vedolizumab every weeks data collected may june outcomes clinical response remission defined harvey bradshaw index health related quality life hrql assessed weeks treatment efficacy population results among patients response week gemini received vedolizumab continuously patients available data remission weeks respectively increased dosing frequency every weeks gemini every weeks gemini lts improved outcomes patients withdrawn early gemini experiencing clinical response remission week gemini lts dose increase similar improvements observed regardless prior tumour necrosis factor tnf antagonist exposure long term benefits hrql also observed conclusions clinical benefits vedolizumab continued long term treatment regardless prior tnf antagonist exposure increased dosing frequency might improve outcomes patients lose response conventional weekly dosing
revision british association psychopharmacology evidence based guidelines treating depressive disorders antidepressants undertaken order incorporate new evidence update recommendations appropriate consensus meeting involving experts depressive disorders management held september key areas treating depression reviewed strength evidence clinical implications considered guidelines revised extensive feedback participants interested parties literature review provided identifies quality evidence upon recommendations made guidelines cover nature detection depressive disorders acute treatment antidepressant drugs choice drug versus alternative treatment practical issues prescribing management next step treatment relapse prevention treatment relapse stopping treatment significant changes since last guidelines published include availability new antidepressant treatment options improved evidence supporting certain augmentation strategies drug non drug management potential long term side effects updated guidance prescribing elderly adolescent populations updated guidance optimal prescribing suggestions future research priorities also made
anxiety disorders among common mental health problems youth faulty interpretation bias positively linked anxiety severity even within anxiety disordered youth quick reliable assessment interpretation bias may useful identifying youth certain types anxiety assessing changes cognitive bias intervention study examined factor structure reliability validity self report ambiguous social situations youth sassy scale self report measure developed assess interpretation bias youth participants age met diagnostic criteria social phobia generalized anxiety disorder separation anxiety disorder exploratory factor analysis performed baseline data youth participating large randomized clinical trial exploratory factor analysis yielded two factors accusation blame social rejection sassy full scale social rejection factor demonstrated adequate internal consistency convergent validity social anxiety discriminant validity evidenced non significant correlations measures non social anxiety sassy social rejection factor accurately distinguished children adolescents social phobia anxiety disorders supporting criterion validity revealed sensitivity changes treatment given relevance youth social phobia pre post intervention data examined youth social phobia test sensitivity treatment effects results suggested sassy scores reduced treatment responders findings suggest potential utility sassy social rejection factor quick reliable efficient way assessing interpretation bias anxious youth particularly related social concerns research clinical settings clinicaltrials gov number nct
sigmadelta modulation currently successful technique used perform high resolution analog digital conversion spite practical success theoretical signal analysis remained limited sigmadelta modulator contains feedback loop includes nonlinear operation amplitude discretization quantization feedback allows use oversampling compensate limitations quantizer resolution precision typical analog circuits however lack signal analysis still clear much resolution conversion gained function oversampling paper show large class sigmadelta modulators feedback loop theoretically yields equivalent feedforward signal flow graph least constant inputs possible thanks remarkable modulo properties modulators equivalence asymptotically extrapolated time varying inputs increasing oversampling although exact components equivalent graph currently known general theoretical structure feedforward graph sufficient point misconceptions current knowledge final resolution nth order sigmadelta modulator specifically except modulator ideal global resolution conversion increases bits per octave oversampling instead currently believed rate bits octave
aims describe prevalence childhood recent trauma patients overactive bladder oab assess impact traumatic events clinical presentation severity oab symptoms quality life psychosocial health methodspatients diagnosed oab age matched healthy controls administered childhood traumatic events scale recent traumatic events scale assessing exposure perceived impact common traumatic events among oab patients validated instruments administered correlate traumatic exposure evaluate adult urinary symptoms iciq iciq oab oab udi iiq uss mood dysregulation hads sleep fatigue promis psychological stress pss resultschildhood sexual trauma prevalent patients oab compared controls oab patients also rated childhood sexual exposure traumatic compared controls mean ratings difference childhood deaths parental upheaval violence illness injury recent traumatic events oab control subjects childhood trauma predicted worse bladder pain worse non urologic pain poorer mood higher anxiety higher physical symptom burden higher psychological stress however childhood trauma correlate severity oab symptoms urgency frequency incontinence conclusionsthirty percent oab patients reported childhood sexual trauma patients report pain symptoms poorer mood greater somatic burden data highlight potentiating role psychosocial stressors childhood adult suffering oab neurourol urodynam wiley periodicals inc
algorithmic computer programming bachelor degree course demands large involvement students performing non standard exercises practical aspect incompatible classical cathedra course reason implement blended learning approach much responsive students bachelor class bio engineering gembloux agro bio tech faculty university liege belgium course alternates theoretical classes take home lessons help online pedagogical resources video debriefing sessions students possibility benefit teacher support students better prepared examination also gain confidence motivation teacher longer simply transmits knowledge assists students reflection process mastering programming tools
methodology realize continuous time current mode tunable ladder filters order presented proposed technique individually simulates signal flow graph sfg branch element passive filter prototype using multi output second generation current controlled conveyors mccciis grounded capacitors leads simple structure ease design suitability fabrication third order butterworth low pass filter third order elliptic low pass filter sixth order chebyshev band pass filter employed demonstrate proposed realization scheme simulated filters retain minimum requirement passive active elements provide filter corner frequency tunability moreover method allows implementation elliptic filters simply adding floating capacitors pole filter structures elsevier gmbh rights reserved
energy consumed schools colleges offices electricity supply lighting cooling hvac equipments hence necessary provide thermal insulation heat outside may enter building summer electricity consumption increases due air conditioning rooms compensate higher ambient temperature present work includes design green building meeting civil construction requirements gyan ganga college technology ggct educational institute energy saving expected proposed energy conservation measures calculated calculated using application software design builder
article study effects temperature control dehydration tomato slices process two control strategies considered pid controller optimal linear control inherent input time delay considered first controller tuned partitions method numerical procedure order minimize quadratic performance index second one considers state predictor compensate effects input delayed energy savings intrinsic characteristics tomato slices vitamin total phenols lycopene levels quantified order conclude advantages two controllers study
psoriasis chronic inflammatory skin disease marked hyper proliferation aberrant differentiation keratinocytes affects world population research pathogenesis psoriasis hampered lack models accurately reflect biology psoriatic phenotype previously reported east indian sandalwood oil eiso significant anti inflammatory properties skin models hypothesized eiso might provide therapeutic benefit psoriasis patients due anti inflammatory anti proliferative properties present interim results going proof concept phase clinical trial topically applied eiso demonstrating well tolerated helpful alleviating mild moderate psoriasis symptoms led evaluate ability eiso affect psoriatic phenotype using mattek corporation reconstituted organotypic psoriatic normal human skin models eiso impact phenotype normal skin tissue model however eiso treatment psoriasis tissue model reverted psoriatic pathology demonstrated histologic characterization expression keratinocyte proliferation markers psoriasin phenotypic affects correlated suppressed production ena mcp csf beta demonstration ability eiso abrogate psoriasis symptoms well characterized vitro psoriatic tissue models supports hypothesis clinically observed symptom alleviation due suppression intrinsic tissue inflammation reactions afflicted lesions study presents systematic approach study underlying mechanisms cause psoriasis presents data supporting potential eiso new ethnobotanical therapeutic concept help direct accelerate development effective therapies
bipolar disorder serious debilitating mental illness frequent relapses often challenging symptoms nature clinical manifestations including severe mood swings significant stressor caregivers patient relatives may experience severe distress impinges overall family functioning may even lead family disruption turn well established family functioning may marked impact course outcome chronic mental illness relevant studies led development psychosocial interventions adjunct pharmacotherapy initially addressing families patients schizophrenia currently forms psychosocial interventions psychoeducational approach usual widely implemented families patients achieve satisfactory outcome life long management psychoeducation provides patient family essential knowledge illness treatment along training communication problem solving skills psychoeducational interventions support caregivers coping effectively problematic behavior patient challenges care improvement family atmosphere development effective coping strategies alleviation burden caregivers constitute crucial determinants overall therapeutic outcome accumulative evidence documents effectiveness psychoeducational intervention decreasing relapses prolonging periods euthymic state reducing number duration hospitalizations
paper suggests novel architecture operational amplifier using circuit method increase high speed response provided due special circuit nonlinear correction extension active operational range input differential stage static current common circuit source maximum slew rate increases times level process technology xfab
model reconstruction important part field reverse engineering become feasible use method create model existing product component cad cam applications various phases reverse engineering reconstruction reviewed details along methodology involved within stages data acquisition crucial stage model reconstruction non touch touch techniques data acquisition studied giving comparative advantages disadvantages face based edge based techniques reviewed segmentation acquired data collected point data obtained stereo lithography stl format popular field modern computer science collected data used construct surfaces using modern cad systems like catia pro etc paper also reviews researches field reverse engineering methods implemented outcome various technologies used limitations reviews latest advancement field model reconstruction
background purpose inverted osteotomy mandibular distraction pierre robin sequence prs useful technique avoiding injury tooth root inferior alveolar nerve identification lingula understudied may decrease iatrogenic complications study aims map position lingula micrognathic mandible compare location lingula relative normal mandible methods retrospective cohort study symptomatic prs patients three dimensional scans reviewed relative lingula position described results study includes prs patients controls average measurements overjet prs versus control vertical ramus height versus width versus horizontal ramus length versus gonial angle degrees versus degrees horizontal lingula position versus vertical position versus ratio along axis prs versus controls along axis ratio versus conclusions compared normal controls overjet greater vertical ramus height widths lesser horizontal ramus length lesser gonial angle greater prs patients analyzed proportions along height width vertical ramus statistical difference position lingula prs patients normal controls
paper presents rational approximation method fractional calculus operators alpha given frequency range error based best rational approximation definition fractional integral operator selected example describe construction rational approximation functions application case used illustrate effectiveness proposed method obtained approximation function frequency domain best rational approximation function improve accuracy approximation without increasing orders basis presented rational approximation method rational approximation equation fractional order pid controller obtained finally method analyzing optimization frequency characteristics fractional order controller implemented demonstrate good frequency characteristic best structure results theoretical analysis experimental verification show proposed method provides new design idea effective application fractional order pid controller engineering
introduction diabetes growing prevalence internationally individuals require insulin part treatment technology evolves optimize delivery improve adherence reduce dosing errors insulin pens outperform vial syringe simplicity dosing accuracy user preference bolus advisors improve dosing confidence treatment adherence inpen system offers novel approach treatment via wireless pen syncs mobile application featuring bolus advisor enabling convenient insulin dose tracking accurate bolus advice among features areas covered existing technology insulin delivery bolus advice reviewed mechanics functionality inpen device delineated findings formative testing usability studies inpen system reported future directions inpen system treatment diabetes discussed expert opinion diabetes management complex largely data driven inpen system offers promising new opportunity avail insulin pen users features known improve treatment efficacy otherwise primarily available using pumps given majority insulin users use insulin pumps inpen system poised improve glucose control significant portion diabetes population
crime victims emotional display legal settings found influence credibility judgments specific nature public expectations crime victims emotional responses however adequately investigated experimental vignette study respondents community sample estimated likelihood female male victims would experience distinct emotions response types crimes across crime types female victims expected experience significantly situation focused anxiety fear inward focused guilt shame sadness emotions significantly less focused emotions hatred anger male victims calls increased focus distinct emotions future research victim emotions implications victims legal social settings discussed
background growing recognition chronic cocaine users alterations sensorimotor control positively related low frontal striatal connectivity within motor system frontal striatal motor circuits however modulated circuits governing attention also disrupted cocaine users study aim determine sensorimotor control deficits positively related difficulty motor task exist independent increasing cognitive demand methods functional mri data collected individuals non treatment seeking chronic cocaine users age gender matched non drug using controls mimicked unpredictable finger tapping sequence various speeds dependent measures included task accuracy percent bold signal change sensorimotor regions interest rois functional connectivity temporal correlations rois results groups speed increased bold signal change increased primary motor cortex supplementary motor area sma cerebellum anterior cingulate cortex compared controls cocaine user sma caudate acc putamen connectivity lower speeds contralateral hemisphere furthermore speed increased decrease connectivity additional roi pairs among users conclusions data support previous observations sensorimotor performance deficits dorsal frontal striatal connectivity impairments among cocaine users previous studies demonstrate deficits performing finger tapping task single speed show impairments exist multiple levels task difficulty data suggest previously observed frontalstriatal connectivity cocaine users sensorimotor task performance stable directly related cognitive demands task published elsevier ireland ltd
objective report contraceptive practices women epilepsy wwe community predictors highly effective contraception use reasons wwe provide selection particular method methods cross sectional data come epilepsy birth control registry ebcr web based survey regarding contraceptive practices wwe community ages years report demographic epilepsy antiepileptic drug aed characteristics well contraceptive use determined frequency use highly effective contraception use methods failure rate year conducted binary logistic regression analysis determine predictors highly effective contraception use report frequencies wwe consult various health care providers regarding selection method reasons cited selection results wwe risk unintended pregnancy use generally considered highly effective contraception hormonal intrauterine device iud tubal vasectomy efficacy wwe especially use hormonal contraception remains proven significant predictors highly effective contraception use insurance insured noninsured race ethnicity caucasian minority age neurologist consult regarding selection method although aed interaction cited top reason selection significance ebcr web based survey first large scale study contraceptive practices wwe community findings suggest need development evidence based guidelines address efficacy safety contraceptive methods special population greater discourse neurologists wwe regarding contraception
purpose present study aims investigate maternal emotion socialization children self perception social problem solving skills addition study describes association levels children self perception social problem solving skills research methods quantitative study adopting relational research design study group consists children aged years attending preschool kirklareli city center school year mothers coping children negative emotions scale ccnes demoulin self perception test children wally social problem solving test wspst personal information form used collect data collected data analyzed spss package program findings results current study demonstrated positive high association total scores children self perception social problem solving skills result study concluded mothers supportive unsupportive reactions could statistically explain children self perception level social problem solving skills implications research practice results suggest children solving problems peers individuals immediate environment developing adequate strategies enables adopt positive attitude self perception addition studies process children emotion socialization contribute relevant literature investigating variables children disposition cultural traits social context live socio economic status family ani publishing ltd rights reserved
characterize brucella infection wild southern sea otter enhydra lutris nereis osteolytic lesions similar reported marine mammals humans otter stranded twice along central california coast period handled extensively two wildlife rehabilitation facilities undergoing multiple surgeries months postsurgical care ultimately otter euthanized due severe progressive neurologic disease necropsy postmortem radiographs revealed chronic severe osteoarthritis spanning proximal interphalangeal joint left hind fifth digit numerous coccobacilli within joint strongly positive brucella immunohistochemical labelling brucella isolated pure culture lesion sparse brucella immunopositive bacteria also observed cytoplasm pulmonary vascular monocyte multifocal granulomas observed spinal cord liver histopathology findings biochemical characterization ribosomal dna gene sequencing bacterial isolate identical marine origin brucellae isolated cetaceans phocids although ompa gene sequencing revealed homology marine brucella spp infecting pinnipeds whales humans ompb gene sequences identical pinniped origin isolates multilocus sequence typing classified sea otter isolate sequence type previously associated cetaceans data suggest sea otter brucella strain represents novel marine lineage distinct brucella pinnipedialis brucella ceti prior reports document zoonotic potential marine brucellae isolation brucella stranded sea otter highlights importance wearing personal protective equipment handling sea otters marine mammals part wildlife conservation rehabilitation efforts
aimsto review assess definitions drug resistance evidence supporting treatment drug resistant overactive bladder detrusor overactivity oab methodsevidence review extant literature consensus opinion used derive summary recommendations resultsdrug resistance drug refractory status inconsistently defined reported current evident sources recent publications use correlation lack efficacy experienced side effects define drug resistance algorithms based upon definitions largely relate appropriate use neuromodulation botulinum neurotoxin based upon patient selection patient choice current treatment pathways hampered inability consistently profile patients optimize management particularly failure initial pragmatic treatment conclusionsfurther research recommended better identify patient phenotype purposes directing optimized therapy oab current treatment algorithms influenced extensive data generated recent neuromodulation botulinum neurotoxin trials
wearable photoplethysmographic sensors form wristbands watches become increasingly popular mobile healthcare propose technique cancel motion artifacts using two reflective pulse signals single green led switched microcontroller high low light intensities accurately estimate motion artifacts applying differential measurement common mode rejection performance assessed four different motion artifacts artificial white noise artificial color noise vertical horizontal random movements hand different condition accurately cancelled motion artifacts
tropical home gardens developing countries traditional land use system contributes basic food requirements farming families well providing small important income throughout year home gardens rely rain survival rainfed systems present home gardens neglected due social environmental problems among issues scarcity water cropping seasons important issue adversely affects crop production home gardens mainly due occurrence unexpected dry periods cropping seasons requirement water source farmer residence irrigate home garden dry spells capture conserve roof runoff home gardens subsequent use appropriate green option mitigate situation microlevel rainwater tanks promoted used collect roof runoff water wet periods enabling farmer irrigate home garden crops dry periods field experiments carried mapalana research farm sri lanka obtain roof runoff coefficients commonly used roof types namely asbestos tiles thatched either straw woven coconut leaves objective case study develop methodology estimate optimum size rainwater tank based roof size roof cover climatic conditions irrigation requirement home garden irrigation paper presents experimental setup runoff coefficients obtained different types roof materials methodology used calculate optimum storage capacity tank home garden irrigation designing rainwater tank sizes microirrigation systems drip pot irrigation systems assessed water use efficiency drip systems comparatively small compared subsurface pot irrigation based tank sizes obtained study roof runoff water farmer roof sufficient recommended used irrigation source home gardens american society civil engineers
electrical arcs emit extremely high intensity light across wide spectrum damage eye delicate structures cornea retina developing industry safety standards mitigate light hazards critical component arc flash safety accurate measurement light intensity first step understanding level eye protection needed traditionally light measurement devices assembly light detecting resistors made cadmium sulfide cds silicon cells however response times inadequate capturing peak light intensity dynamic changes initial arc flash addition brightness arc flash greater measurable light levels traditional light measurement devices furthermore light sensitivity traditional sensors match commission internationale eclairage luminosity function lambda curve defines human eye sensitivity bright light function wavelength typical ambient light conditions paper discusses novel light measurement technique overcome limitations traditional approaches design capable measuring light intensity arc flash perceived human eyes results used evaluate potential arc flash harm eyes
year old italian woman came center revaluation previous diagnosis polycythemia vera patient presented lifelong history polycythemia increase white blood cells wbcs platelets negative bone marrow biopsy analysis hemoglobin fractions showed abnormal fast moving component aimed determine variant cause polycythemia patient complete blood count cbc performed automated cell counter fractions determined high performance liquid chromatography hplc standard stability tests oxygen affinity evaluation also performed genomic dna extracted peripheral blood leukocytes using phenol chloroform method entire globin gene analyzed direct sequencing hematological level anemia hemolysis observed abnormal fraction detected using cation exchange hplc molecular analysis globin gene showed heterozygosity aag acg substitution codon resulting lysthr amino acid replacement demonstrated new variant increased oxygen affinity altered physiology caused reduction diphosphoglycerate dpg effects due amino acid substitution central pocket near terminal chain called new variant san cataldo native city proband
non competitive nmda receptor antagonists known induce psychosis like symptoms rodents administration compounds cause behavioural effects memory impairment hyper locomotion additionally drugs phencyclidine pcp ketamine cause distinctive increases striatal local field potential lfp high frequency oscillation hfo band power spectrum amperometric sensors provide means measure tissue oxygen bold like signal brains freely moving rats simultaneously acquiring lfp using electrode carbon paste electrodes implanted striatum hippocampus male wistar rats rats administered saline ketamine pcp recordings made khz using three different potentials measure control conditions nmda receptor antagonism caused significant increases striatum hippocampus power spectrum analysis showed significant increases hfo power striatum hippocampus conversely significant decreases delta alpha power along increases theta gamma power hippocampus absent striatum supports findings lfp obtained amperometric sensor signal allowing simultaneous acquisition two translational biomarkers neuronal activity lfp elsevier ltd rights reserved
high frequency rotation speed analysis design methods high speed machine different conventional ones rotor stress calculation rotor dynamics analysis electromagnetic design view outer rotor permanent magnet claw pole machine proposed claw pole wingding designed analyzed equivalent magnetic circuit finite element method fem rotor stress distribution calculated check strength rotor bending mode critical speed simulated analyze dynamics properties finally prototype developed test research prototype carried feasibility accuracy theoretical analysis verified experimentation
tobacco addiction serious psychosocial health problem pregnant woman smokes influences maternal organism also passes health risks unborn child fetus exposed maternal smoking directly influenced also endangered wide range diseases adult years components tobacco smoke play significant role development number diseases large proportion smoking population well among pregnant article summarizes findings regarding impacts production steroid hormones first describing smoking related changes steroidogenesis women focusing influence maternal smoking fetus developing steroidogenesis assume prenatal development fetus already exposed effect endocrine disruptors time fetal steroidogenesis begins fetal programming exposure serious pathophysiological effects pregnancy well later life example effects might delay creation kidney adrenal androgens could also evident level steroid neuroactive metabolites may influence individual psychological state lead later addictions published elsevier ltd
objective study examined symptom reporting related edition international statistical classification diseases related health problems icd criteria postconcussional syndrome pcs operation enduring freedom oef operation iraqi freedom oif veterans aims examine relationships among pcs symptoms identifying potential subscales british columbia postconcussion symptom inventory psi examine group differences psi items subscales veterans without blast exposure mild traumatic brain injury mtbi posttraumatic stress disorder ptsd method sample included veterans blast related mtbi history blast exposure mtbi history without blast exposure overall veterans ptsd conducted exploratory factor analysis efa psi followed multivariate analysis variance examine differences psi subscale scores blast exposure mtbi history ptsd results psi factors interpreted cognitive vestibular affective anger somatic items factor scores highest veterans blast exposure plus mtbi lowest controls vestibular affective somatic factors significantly higher veterans blast exposure plus mtbi controls significantly different blast exposure mtbi results remained significant ptsd symptom severity included covariate cognitive anger somatic subscales significantly higher veterans ptsd though interaction effect ptsd mtbi blast history conclusions efa derived subscales psi differentiated veterans based blast exposure mtbi history ptsd
even though green building concept fairly new malaysia development industry growing recent years prior launch malaysia standard namely green building index gbi one criteria assessed gbi energy efficiency takes overall assessment considering passive design included green building concept reduce energy usage without compromising occupant thermal comfort study attempts assess passive design effectiveness terms indoor air quality green office buildings tropics two green office buildings incorporated radiant slab cooling conventional cooling system selected case studies detailed assessment terms thermal comfort parameters temperature relative humidity indoor pollutants concentration carbon dioxide carbon monoxide formaldehyde air movement carried results showed thermal comfort parameters fall within malaysian standard ashrae standard except air movement buildings based results obtained future buildings using radiant slab cooling better comfort level lesson learned buildings
highly linear pga level shifter class output stage ble receiver reported paper merits degenerated pga operational amplifier based pga synthesized proposed pga implemented cmos process draws current supply driving capacitor load mhz high obtained oip dbm achieved gain modes due constant loop bandwidth proposed pga gain range step thd reaches frequency mhz proposed pga outputs vpp differential voltage signal
pericardial effusion cause cardiac tamponade physiology resultant cardiogenic shock death myelofibrosis replacement marrow cavity fibrous connective tissue secondary complication group disorders known myeloproliferative neoplasms clonal processes characterized abnormal proliferative growth one hematopoietic lineages one consequence myelofibrosis development hematopoiesis anatomic sites commonly spleen liver phenomenon known extramedullary hematopoiesis emh herein report case man died pericardial tamponade due subacute pericardial effusion secondary emh pericardium setting myelofibrosis case highlights unusual etiology pericardial effusion tamponade considered cases myelofibrosis stimulates discussion regarding mechanisms anatomic distribution emh elsevier inc rights reserved
self aggregation sodium dodecylsulphate sds anionic surfactant aqueous solutions tetraalkylammonium bromide salts rnbr propyl butyl pentyl determined various temperatures range critical micelle concentration cmc determined conductivity data used study thermodynamics surfactant presence bromide salts found affect micellization sds accordance hydrophobicity tetraalkylammonium cations thus cmc values follow order additive prnbr bunbr pen nbr results conventional conductivity methods combined spectroscopic techniques like fluorescence vis studies
discuss future massively parallel computing fundamental architecture standpoint central thesis various versions moore laws unavoidably break next two three decades due fundamental limitations imposed laws physics especially quantum mechanics therefore end scaling von neumann based architectures adding cores incremental technology advancements within sight challenges overcome order continue making computation faster cheaper energy efficient reliable one possible answer lies connectionist massively parallel models based artificial neural networks paradigms biology neuroscience statistical physics discuss would massively parallel connectionist computers like based implementing neural networks hardware undertake several thought experiments comparing contrasting hypothetical connectionist parallel machines classical multicore supercomputers large scale distributed computing systems
paper reviews grinding research led professor brian rowe liverpool john moores university establishments previously research reviewed extends fundamentals grinding processes machine performance carried fifty five years topics range accuracy centreless grinding grinding processes grinding machine behaviour high precision grinding machine design including bearing technology research also ranges high removal rate grinding processes surface integrity intelligent process control review highlights progress selected areas demonstrates improving product quality allows improved manufacturing productivity
three dimensional tissue models invaluable tools closely reflect vivo physiological environment however usually difficult develop low throughput often costly limiting utility laboratories recent availability inexpensive additive manufacturing printers open source design software offers possibility easily create affordable cell culture platforms demonstrate established simple inexpensive robust method producing arrays free floating epithelial micro tissues using combination computer aided design printing hydrogelmicro moulding collagen cell encapsulation engineered microenvironments consistently direct growth micro tissue arrays described adaptability technique testing several immortalised epithelial cell lines mdck caco generating branching morphology micron millimetre scaled micro tissues established fluorescence electron microscopy micro tissues polarised cell type specific differentiated phenotypes regain native vivo tissue qualities finally using salmonella typhimurium show micro tissues display physiologically relevant infection response compared epithelial monolayers grown permeable filter supports summary developed robust adaptable technique producing arrays epithelial micro tissues vitro model potential valuable tool studying epithelial cell tissue function architecture physiologically relevant context
advantage iccg method solving large sparse matrix taken fdtd equation solving iccg fdtd accelerate iteration numerical calculation reduce memory overhead maxwell equation electromagnetic wave dispersive medium plasma deduced format differentiated time domain fdtd method become unconditionally stable process large sparse matrix generated solving matrix iccg method sufficient advantages iccg method convergence fast stable quite easy computer programming addition data required iccg method memorized computer format one dimensional compression helps computer memory save large amount capacity especially issues rather complex cope algorithm display strength advantages iccg method able calculate reflection coefficient transmission coefficient electromagnetic waves plasma well phase angle calculation indicates time step required iccg fdtd method eliminated constraints cfl thus shortening required time making calculated result stable accurate improving efficiency programming elsevier gmbh rights reserved
pressing demand deploy software updates without stopping running programs fostered much research live update systems past decades prior solutions however either make strong assumptions nature update require extensive error prone manual effort factors discourage adoption live update paper presents mutable checkpoint restart mcr new live update solution generic multiprocess multithreaded server programs written compared prior solutions mcr support arbitrary software updates automate common live update operations key idea allow running version safely reach quiescent state allow new version restart similarly fresh program initialization possible relying existing code paths automatically restore old program threads reinitialize relevant portion program data structures transfer remaining data structures mcr relies combination precise conservative garbage collection techniques trace global pointers apply required state transformations fly experimental results popular server programs apache httpd nginx openssh vsftpd confirm techniques effectively automate problems previously deemed difficult cost negligible performance overhead percent average moderate memory overhead average without optimizations
intrusion detection become essential network security increasing connectivity computers several intrusion detection systems developed protect networks using different statistical methods machine learning techniques study aims design model deals real intrusion detection problems data analysis classify network data normal abnormal behaviors study proposes multi level hybrid intrusion detection model uses support vector machine extreme learning machine improve efficiency detecting known unknown attacks modified means algorithm also proposed build high quality training dataset contributes significantly improving performance classifiers modified means used build new small training datasets representing entire original training dataset significantly reduce training time classifiers improve performance intrusion detection system popular kdd cup dataset used evaluate proposed model compared methods based dataset proposed model shows high efficiency attack detection accuracy best performance thus far elsevier ltd rights reserved
high piezo photo catalytic efficiency degrading organic pollutants realized cus zno nanowires using solar mechanical energy cus zno heterostructured nanowire arrays compactly vertically aligned stainless steel mesh simple two step wet chemical method mesh supported nanocomposites facilitate efficient light harvesting due large surface area also easily removed treated solution solar ultrasonic irradiation cus zno nanowires rapidly degrade methylene blue aqueous solution recyclability investigated process ultrasonic assistance greatly enhance photocatalytic activity performance attributed coupling built electric field heterostructures piezoelectric field zno nanowires built electric field heterostructure effectively separate photogenerated electrons holes facilitate carrier transportation cus component improve visible light utilization piezoelectric field created zno nanowires separate photogenerated electrons holes driving migrate along opposite directions present results demonstrate new water pollution solution green technologies environmental remediation industrial level
differential hybrid charge sensitive preamplifier csp designed taking monolithic dual channel junction field effect transistor jfet high speed low noise operational amplifier core parts input stage circuit employs low noise differential dual jfet ensures high input impedance low noise differential dual transistor makes quiescent point first stage differential output stable convenient connecting post stage high speed operational amplifier broadband could amplified connecting double differential dual transistors folded cascode bootstrap amplifying circuit replaces interstage post stage discrete components traditional csp integrated operational amplifier simpler reliable simplifies design quiescent point gives full play advantages releasing large open loop gain improves charge voltage conversion gain stability particularly charge voltage conversion gain larger smaller feedback capacitor thus enabling gain better signal noise ratio designed csp tested reporting charge sensitivity rise time signals signal noise ratio gamma rays kev noise slope gamma rays kev measured bpx detector designed csp room temperature providing energy resolution
automatic registration multimodal remote sensing data optical light detection ranging lidar synthetic aperture radar sar challenging task due significant nonlinear radiometric differences data address problem paper proposes novel feature descriptor named histogram orientated phase congruency hopc based structural properties images furthermore similarity metric named hopcncc defined uses normalized correlation coefficient ncc hopc descriptors multimodal registration definition proposed similarity metric first extend phase congruency model generate orientation representation use extended model build hopcncc fast template matching scheme metric designed detect control points images proposed hopcncc aims capture structural similarity images tested variety optical lidar sar map data results show hopcncc robust complex nonlinear radiometric differences outperforms state ofthe art similarities metrics ncc mutual information matching performance moreover robust registration method also proposed paper based hopcncc evaluated using six pairs multimodal remote sensing images experimental results demonstrate effectiveness proposed method multimodal image registration
discrete time robust disturbance attenuation problem degrees freedom dof mechanical systems uncertain energy function considered paper first shown continuous time setting robust control problem dof mechanical systems reduced disturbance attenuation problem specific type control rule used afterwards robust disturbance attenuation problem formulised special disturbance attenuation problem discrete time counterpart problem characterised means gain given finally solution problem via direct discrete time design presented sufficient condition proposed discrete time design utilizes discrete gradient energy function considered system therefore new method also proposed using quadratic approximation lemma construct discrete gradients general energy functions proposed direct discrete time design method used solve robust disturbance attenuation problem double pendulum system simulation results given discrete gradient obtained method presented paper note solution presented robust disturbance attenuation problem give explicit algebraic condition design parameter whereas solution problem requires solving hamilton jacobi isaacs partial differential inequality general nonlinear systems
limited information regarding neurobiology underlying non suicidal self injury nssi clinically referred youth however salience disturbed interpersonal relationships disrupted self processing associated nssi suggests neural basis social processes key area additional study adolescent participants years divided three groups nssi plus depression diagnosis nssi depression dep healthy controls scanner participants completed interpersonal self processing task taking direct indirect mothers best friends classmates perspectives regarding self characteristics across perspectives nssi showed higher bold activation limbic areas anterior posterior cortical midline structures versus dep showed greater activity rostrolateral frontal pole occipital cortex nssi dep youth moreover nssi youth showed heightened responses amygdala hippocampus parahippocampus fusiform taking mothers perspective negatively correlated self reports mother support adolescents emotional distress nssi group nssi youth also yielded greater precuneus posterior cingulate cortex activity indirect self processing classmates perspective findings suggest role disruptions self emotion processing conflicted social relationships neurobiology nssi among depressed adolescents elsevier ireland ltd rights reserved
study presents novel reactor based ferroresonance fault current limiter drffcl stabilising ferroresonance oscillations potential transformer distribution network decreasing amplitude fault current acceptable level first ferroresonance overvoltage introduced various types overvoltage studied effects suggested drffcl oscillations investigated shown proposed drffcl control ferroresonance oscillations also decrease fault current amplitude case short circuit faults occurrence drffcl performance simulated using matlab software scaled laboratory prototype implemented tested simulation results validation measured results agreement simulation results clearly show ability drffcl controlling ferroresonance overvoltage fault current
paper active charging stations electric cars active charging station usually part modern electrical grids known smart grids micro grids paper also includes executive summary existing knowledge structure service electricity distribution network analysis electric car industry potential impact electrical network also conceptual solution charging stations electric cars minimal effects power network
develop social group utility maximization sgum framework cooperative wireless networking takes account social relationships physical coupling among users specifically instead maximizing individual utility overall network utility user aims maximize social group utility hinges heavily social tie structure users show framework provides rich modeling flexibility spans continuum non cooperative game network utility maximization num two traditionally disjoint paradigms network optimization based framework study three important applications sgum database assisted spectrum access power control random access control respectively case database assisted spectrum access show sgum game potential game always admits socially aware nash equilibrium sne also develop distributed spectrum access algorithm converge sne also quantify trade performance convergence time algorithm cases power control random access control show exists unique sne network performance improves strength social ties increase numerical results corroborate sgum solutions achieve superior performance using real social data trace furthermore show sgum framework generalized take account positive negative social ties among users useful tool studying network security problems
review explores prevalence factors associated disturbed sleep patients ankylosing spondylitis non radiographic axial spondyloarthritis order clarify consistent findings otherwise disparate research field association physical demographic psychological factors correlating poor sleep explored effectiveness interventions assessed ten electronic databases searched amed cinahl embase medline psycinfo pubmed scopus web science opengrey base following application inclusion exclusion criteria articles critically assessed basis methodology experimental design ethics quality sleep data leading selection studies final review poor sleep reported patients axial spondyloarthritis prevalent within clinical population compared healthy control subjects disturbed sleep important aspect disease patients reflects severity disease activity pain fatigue functional disability however direction relationship undetermined associations age gender years spent education quality life depression also demonstrated anti tnf medication effective reducing poor sleep exercise also produced beneficial results future research poor sleep take account multifactorial nature also current lack research investigating non pharmacological interventions combination therapies standardised validated measurement poor sleep appropriate regular patient screening would useful first step future research
present demonstrate highly stabilized non isolated single mode brillouin fiber laser utilizing novel simple inexpensive approach locking cavity length scheme based intuitive control algorithm programmed embedded microcontroller characterized smooth control signals laser cavity length controlled real time using piezoelectric actuator according pump level inside cavity using control scheme demonstrate ultra stable non isolated brillouin fiber laser power variations similar lasing frequency drift hundreds kilohertz best knowledge first comprehensive report frequency stability properties controlled bfls compare stability laser non controlled cavities investigate impact minimal isolation discuss various parameters affected achievable stability govern laser short long term stabilities demonstrated approach highly attractive real life lab applications sufficient thermal mechanical isolation difficult expensive obtain
aim study assess observed changes emotion dysregulation obtained systems training emotional predictability problem solving stepps program sample composed subjects personality disorder borderline features participants filled difficulties emotion regulation scale ders significant decrease ders total score end treatment month follow friedman test showed significant decrease suicide attempts hospitalizations time analysis ders subscales showed goals impulse two dimensions treatment acted changes stable time stepps associated improvement emotion regulation reduction number hospitalizations suicide attempts treatment seems act behavioral dimensions emotion dysregulation like ability control impulsive behaviors achieve goals
bone turnover markers btms product bone cell activity generally divided bone formation bone resorption markers purpose review structure available information use btms studies small ruminants especially monitoring variations related diet exercise gestation metabolic lactation state circadian seasonal variations also skeletal growth pre clinical translational studies using btms sheep goats animal models orthopaedic research studies help evaluation fracture healing process osteoporosis research also described review available information reviewed studies systematically organized order highlight promising btms small ruminant research well provide wide view use sheep goat animal models orthopaedic research type markers commercial assay kits cross reactivity sheep goat method sample storage serum urine bone turnover markers determination usefulness limitations bone turnover markers different studies therefore effective tool researchers seek answers different questions using btms small ruminants
paper first make brief review general method solving master equation density operator includes number method method super operator method number transform quantum master equation fokker plank equation differential equation density matrix elements method wide applicable range fokker plank equation differential equation difficult solve besides solution always applicable initial condition super operator method solve master equation efficiently compared number method however solving process super operator method mostly depends characteristics lie algebra instance corresponding lindblad operator divided generators lie group super operator longer applicable thus although super operator efficiently number method narrow applicable range furthermore researchers made much effort develop super operator method instance wang proposed left right action operator left operator general operator right action operator right side acts general operator thus explicit formation super operator given method fan proposed thermal entangled state representation convert operator real mode fictitious mode developments depend lie algebra thus narrow applicable range like super operator method introduce new ket bra entangled state kbes method paper transform master equation schrodinger like equation corresponding ket bra entangled state one use method schrodinger equation time evolution method perturbation method etc solve master equation compared number method super operator method kbes method several merits wide applicable range kbes method applicable master equation finite level system theory compatibility computer programming crucial procedure calculate exponent lindblad operator needs diagonalization finished computer mature methods schrodinger equation used solve master equation kbes method transform master equation schrodinger like equation study model two level qubit coupled reservoir time varying external field corresponding master equation deduced solved kbes method furthermore analyze decoherence evolution density operator consider entanglement evolutions two uncoupled qubit cases find external field seriously influences decoherence process diagonal elements rho become damply oscillated external field exists frequency oscillate keeps growing along lambda gamma besides dynamic evolution concurrence also influenced external field leads occurrence entanglement sudden death entanglement sudden birth last esb phenomenon happens external field thus thought one suppress decoherence disentanglement process exerting suitable time varying external field open system course suitable external field also obtained kbes method theory
aim identify set contributors weight rank pathophysiological basis methods patients undergone lactulose glucose hydrogen breath test rule small intestinal bacterial overgrowth sibo various clinical symptoms including diarrhoea weight loss abdominal pain cramping bloating seen eligible inclusion retrospective single centre study clinical data morbidities medication laboratory parameters possible risk factors identified electronic data system cases lacking substantially incomplete clinical data excluded analysis suspected contributors summarised four different pathophysiological pathways impaired gastric acid barrier impaired intestinal clearance immunosuppression miscellaneous factors including thyroid gland variables investigated using chi test student test logistic regression models results total patients undergone hydrogen breath testing analysed impairment gastric acid barrier gastrectomy odds ratio ppi therapy impairment intestinal clearance resecting gastric surgery colonic resection stenosis gastroparesis neuropathy immunological factors drug induced immunosuppression altered thyroid gland metabolism hypothyroidism levothyroxine therapy diabetes mellitus associated significantly sibo abdominal surgery ileocecal resection vagotomy iga deficiency influence history appendectomy decreased risk sibo multivariate analysis revealed gastric surgery stenoses medical immunosuppression levothyroxine strongest predictors levothyroxine therapy strongest contributor simplified model conclusion important contributors development sibo ascending order immunosuppression impairment intestinal clearance levothyroxine use sufficiently explain emergence
water one important resources world essential life recently several strategies proper use water different sectors industrial agricultural domestic ported involve options recycling reusing regeneration however overall water management macroscopic level received lower attention macroscopic level numerous water uses involved several sources freshwater interact satisfy freshwater demands also recycling reusing regeneration strategies implemented therefore paper proposed new optimization formulation proper use water macroscopic level involving water recycling reusing regeneration well accounting impact surrounding watershed case study central west part mexico analyzed results show possible reduce freshwater consumption investment year
paper efficiency biosorbent prepared mikania micrantha remediate hazardous dye alizarin red aqueous phase investigated morphological constitutional characteristics biosorbent studied performing sem ftir adsorption equilibrium modeled langmuir freundlich isotherm maximum monolayer adsorption capacity found degrees isotherm data better fitted freundlich model indicated heterogeneous nature adsorbent negative values delta degrees positive value delta degrees demonstrated adsorption alizarin red onto mikania micrantha spontaneous endothermic nature respectively positive value delta degrees advocated randomness solid liquid interface
introduction diagnostic discrimination inflammatory bowel disease ibd functional gastrointestinal disorders complex cause similar signs symptoms faecal calprotectin useful marker context used select patients benefit colonoscopy aim study evaluate utility discriminating organic disease functional disorders material methods study included patients presenting gastrointestinal complaints consistent organic pathology levels determined diagnostic accuracy assessed using area curve obtained final diagnosis results calprotectin levels organic bowel disease patients significantly higher median confidence interval interquartile range functional disease patients similarly patients ibd values obtained higher irritable bowel syndrome cut area roc curve discriminate organic functional disease discriminate irritable bowel syndrome ibd conclusion study supports importance marker evaluation patients ibd best diagnostic accuracy obtained cut value elsevier espana aeeh aeg rights reserved
antimony toxic relatively low concentrations may exist groundwater surface water bodies investigated potential oxidation adsorption pathways iii species presence oxidizing bacteria without batch experiments conducted determine oxidation adsorption characteristics species presence biogenic oxides bmos formed situ via oxidation oxidizing bacterium pseudomonas qjx results indicated iii ions could oxidized ions bmo originating iii oxidation adsorbed effectively bmo introduced chemically oxidized feooh precipitates mixed bmo form new compound biogenic oxides bfmo bmo part bfmo mainly oxidized feooh bfmo mainly adsorbed species aquatic solutions containing iii iii bfmo formed situ preferentially oxidized adsorbed efficiently chemical analysis reverse transcription real time polymerase chain reaction revealed presence iii iii accelerated oxidation inhibited activity oxidizing bacteria results provide significant insights biogeochemical pathways aquatic ecosystems without research center eco environmental sciences chinese academy sciences published elsevier
present study attempt estimate energy exergy potential biogas run dual fuel diesel engine using emulsified rice bran biodiesel rbb pilot fuel varying compression ratio injection timing objective arrive optimum setting engine based dual fuel characteristics using energy exergy analysis pilot fuel considered study two phase stable water emulsion rbb water content surfactants hydrophilic lipophilic balance value experimentation single cylinder direct injection natural aspirated water cooled variable vcr diesel engine converted dual fuel engine experiments conducted different combinations deg deg deg deg bottom top dead center btdc full load conditions brake mean effective pressure bmep bar parameters analyzed energy exergy potential fuel input shaft work cooling water exhaust gas exergy destruction peak cylinder pressure pcp peak heat release rate phrr brake thermal efficiency bte exergy efficiency exhaust gas temperature egt entropy generation rate emission analysis results indicate combination deg btdc gives better thermodynamic performance particular range operating parameters raw biogas run dual fuel diesel engine using emulsified rbb pilot fuel
according huaxi group blind inclined shaft hoisting machine adopts tkd control system speed control performance poor control circuit complex high noise stability low reliability paper proposes scr system replace original scheme reforming electric control system paper introduces structure working principle scr system shows main equipment selection main circuit gives system installation adjustment result shows reformed electric control system characteristics perfect protection control high precision good energy saving effect achieved expected goal
network structures human behaviors considered two important factors virus defense currently however due ignorance network security normal users usually take simple activities reinstalling computer system using computer recovery system clear virus system recovery influences virus spreading taken consideration currently paper new virus propagation model considering system recovery proposed first steady state analysis virus propagation steady time steady states deduced experiment results show models considering system recovery effectively restrain virus propagation furthermore algorithm system recovery scale free network proposed simulation result turns target immunization strategy system recovery works better traditional ones network
use building information modelling bim related software tools increasingly expanding work site managers construction projects early uses bim actual tasks site managers explored examining utilization bim work challenges deployment new digital tools traditional project collaboration ethnographic method study consists shadowing site managers work site managers actively used bim found beneficial daily work however use bim construction sites still limited managers competence use bim software tools mobile tools lacking information content models needed construction work insufficient
background individuals aphasia often excluded studies exploring poststroke cognition many standard cognitive assessments rely language ability primary objective examine association performance cognitive tests performance comprehension naming tests poststroke aphasia second aimed determine association language performance real life measure cognition kettle test third explored feasibility administering cognitive tests aphasia methods thirty six participants poststroke aphasia controls assessed battery pen paper cognitive tests recommended stroke auditory comprehension measured using comprehensive aphasia test naming measured using boston naming test twenty two community dwelling participants aphasia controls also asked complete kettle test multiple linear regressions used explore relationship language performance performance cognitive tests feasibility determined quantifying missing data results cognitive tests highest variance accounted auditory comprehension naming animal fluency hopkins verbal learning test recognition discrimination index cognitive tests significantly associated auditory comprehension naming except star cancellation test kettle test thirty three percent participants aphasia unable complete cognitive tests conclusion language non linguistic cognitive processes often interrelated pen paper cognitive tests significantly associated auditory comprehension naming even tests require verbal response language performance significantly associated real life cognitive performance measure task instructions stimuli responses completion need tailored individuals aphasia minimize influence language deficits testing non linguistic cognitive performance
intimate partner violence ipv sub saharan africa affects population several african countries rank among highest globally article present evidence prevalence determinants impact ipv across several sub saharan african countries interpreted backdrop social ecological theory also describe prevention intervention programs tested different regions africa selecting programs published journal outlet met high criteria implementation methodology based review empirical literature risk factors violence documented western societies africa including poverty drinking past history child abuse posttraumatic stress disorder highly traditional gender role beliefs low education also associated ipv women men africa partner abuse intersects hiv pandemic making violence prevention especially urgent african programs prevent ipv often incorporated hiv prevention community building community engagement emphasized africa north america europe invoke individually focused approaches programs review lowered hiv exposure women others contributed reduced violence perpetration among men programs show sufficient promise recommend replication dissemination sub saharan africa
study aimed recognize personality factors predisposition seasonal mood fluctuations non clinical sample group subjects women men mean age years completed battery tests comprising seasonal pattern assessment questionnaire spaq chronotype questionnaire chq neo five factor inventory coping inventory stressful situations ciss smaller sample completed winter blues scale wbs women scored significantly higher men seasonality neuroticism agreeableness avoidance oriented coping style subjects seasonal affective disorder sad sub sad diagnosed spaq exhibited higher levels neuroticism openness comparison non sad individuals latter declared less frequent avoidance coping style measures seasonality spaq global seasonality score wbs correlated significantly respectively subjective amplitude circadian rhythm described distinctness scale chq female gender neuroticism openness confirmed factors linked seasonal mood variability additionally study revealed association susceptibility mild winter depression avoidance oriented coping style avoidance coping style correlated positively aspects seasonality described spaq correlation coefficients sub types avoidance oriented style distraction social diversion associated marked subjective seasonal changes sleep length mood energy level subjective amplitude circadian rhythm proved connected seasonality subjective acrophase rhythm morningness eveningness preference may hypothesized sensitivity natural environmental conditions synchronizers separate individual trait shaping subject proneness energy mood changes diurnal year scale circadian seasonal mood variations
simple phenomenon water drop falling onto glass plate may seem like trivial fluid mechanics problem however detailed imaging shown process highly complex small air bubble always entrapped drop makes contact solid bubble interfere uniformity spray coatings degrade inkjet fabrication displays etc describe use high speed interferometry million frames per second understand details process impacting drop approaches solid dynamics characterized balance lubrication pressure thin air layer inertia bot tom drop deforms drop forming dimple bottom making drop touch surface along ring thereby entrapping air layer typically thick air layer highly compressed deceleration bottom drop large describe thicknessevolution lubricating air layer extracted following interference fringes frames two color interferometry also used extract absolute layer thicknesses finally identify effects nanometric surface roughness first contact drop substrate need resolve thickness changes occurring intervals requiring state art high speed cameras surprisingly see ring micro bubbles marking first contact drop glass microscope slides typical roughness rings absent drop impacts onto molecularly smooth mica surfaces
put practice flipped classroom way utilizing learning contents computer programming course since main feature practice use time usually dedicated lecture practicing assigning students learning materials preparation class gave students homework learn vocabularies grammar programming language decreased time teacher spent lecturing students assigned applied problems make practical software addition conventional basic problems training goal maintain students motivation learn computer programming sense accomplishment student obtains finishing practical assignments training confirmed effectiveness approach comparing examination scores last year year putting questionnaires students additionally analyzed learning situation students week programming results shown paper
background purpose epidemiological data suggests excess risk cardiovascular disease cvd low doses ionizing radiation furthermore underlying biological molecular mechanisms radiation induced cvd still unclear damage endothelium could critical related cvd study aimed identify effects radiation immortalized endothelial cells context atherosclerosis material methods microarrays qpcr used compare response endothelial cells irradiated single ray dose measured various post irradiation repair times day days days consolidate mechanistically support endothelial cell response ray exposure identified via microarray analysis dna repair signaling gamma hax tpbp foci quantification cell cycle progression brdu aad flow cytometric analysis cellular senescence beta galactosidase assay cprg igfbp quantification pro inflammatory status ccl assessed results microarray results indicated persistent changes cell cycle progression inflammation cells underwent arrest dose dependent manner high doses compensated increased proliferation week almost normalized weeks however point irradiated cells showed increased beta gal activity igfbp secretion indicative premature senescence production pro inflammatory cytokines ccl increased early time points conclusions induces pro atherosclerotic processes endothelial cells dose dependent manner findings give incentive research shape dose response curve show even low doses induce premature endothelial senescence later time points furthermore findings time dose dependent response regarding differentially expressed genes cell cycle progression inflammation senescence bring novel insights underlying molecular mechanisms endothelial response ray radiation may turn lead development risk reducing strategies prevent induced cvd use cell cycle modulators anti inflammatory drugs radioprotectors radiation mitigators
utilising qualitative case study approach research study set understand discrimination experienced immigrant students interactions south african students prejudice immigrant students expressed black south african students findings reveal discrimination experienced immigrant students could clustered four broad themes namely categorisations prototypes practised stereotypes academic social exclusion work ethic furthermore statements immigrant students make south african students seem fall two broad categories namely lack value moral integrity lack value education educating students value human dignity view cosmopolitan citizens world could way ensure social cohesion harmony future generations come
wireless laser communication wlc emerging effective last mile solution high rate data transmission consists transmitter receiver atmosphere unguided propagation medium transimpedance design based optical receivers employed till still involve unwanted compromise bandwidth noise influenced capacitance photodiode suggest operational transresistance amplifier otra based receiver section link arrangement otra new building block field analog signal processing show highly improves upon compromise bandwidth noise also show proposed receiver section highly improves upon contemporary receiver designs provides several unique useful advantages using otra based band pass filter employed receiver section
water supply reliability expected affected precipitation amount distribution changes recent future climate change compare historical changes annual mean annual maximum daily precipitation global set station observations global historical climatology network climate models inter sectoral impact model intercomparison project isi mip develop study model projections high radiative forcing scenario rcp develop simple rainwater harvesting system rwhs model drive observational modeled precipitation study changes mean maximum precipitation along changes reliability model rwhs tools assess impact changes precipitation amount distribution reliability precipitation fed water supplies results show faster increase observed maximum precipitation per global warming mean precipitation per increased reliability model rwhs driven observed precipitation average per decade isi mip models show even faster increase maximum precipitation compared mean precipitation however imply decreases mean reliability average per decade compared observations climate models underestimate increasing trends mean maximum precipitation show opposite direction change reliability model water supply system
autoimmune diseases high prevalence population autoimmune thyroid disease aitd one common representatives thyroid autoantibodies frequently detected patients aitd also subjects without manifest thyroid dysfunction high prevalence raises questions regarding potential role extra thyroidal diseases review summarizes etiology mechanism aitd addresses prevalence antibodies thyroid peroxidase thyroid stimulating hormone receptor tshr anti thyroglobulin action outside thyroid main issues limiting reliability conclusions drawn include problems different specificities sensitivities antibody detection assays employed well potential confounding effects altered thyroid hormone levels lack prospective studies addition well known effects tshr antibodies fibroblasts graves disease studies speculate role anti thyroid antibodies cancer antibodies may tumor promoting role breast cancer carcinogenesis despite anti thyroid peroxidase antibodies positive prognostic effect patients overt disease cross reactivity lactoperoxidase leading induction chronic inflammation might promote breast cancer anti thyroid antibodies manifest breast cancer might indication active immune system better general health condition older women anti thyroid peroxidase antibodies might support hypothesis different actions anti thyroid antibodies correspond differences cellular location antigens titers circulating antibodies duration antibody exposure immunological mechanisms hashimoto thyroiditis
paper deals inertial cavitation single gas bubble liquid submitted ultrasonic wave aim calculate accurately pressure temperature bubble wall liquid adjacent wall collapse two different approaches proposed modeling heat transfer ambient liquid gas simplified approach liquid acting perfect heat sink rigorous approach liquid acting normal heat conducting medium time profiles bubble radius gas temperature interface temperature pressure corresponding models compared important differences observed excepted bubble size exact pressure temperature distributions liquid corresponding second model also presented profiles necessary prediction physical phenomena occurring around cavitation bubble possible applications sono crystallization elsevier rights reserved
background contribution women mobility hiv aids epidemic africa poorly understood despite women high mobility evidence associated higher risk sexual behavior sought measure levels mobility hiv prevalence related risk behaviors among female traders kisumu kenya methods used global positioning system mapping develop probability based sample recruited female market traders participation survey voluntary hiv counseling testing estimated hiv prevalence fitted logistic regression models measure associations mobility risk behaviors hiv infection results hiv prevalence confidence interval migrated changed residence county national boundary past year past years one third spent nights away main residence past month spending week away multiple partners reported women last year married women reported concurrent partnership mobility significantly associated hiv prevalence although recent short term mobility significantly correlated higher numbers sexual partners past year conclusions female market traders highly mobile hiv prevalence among traders higher general population women reproductive age kisumu nyanza province kenya high hiv prevalence risk behavior among women study warrant accelerated attention hiv prevention care needs mobile women including market traders
purpose purpose paper empirically examine effect investments organisational resources corporate governance features market based performance islamic banks ibs design methodology approach required data calculate different constituents banks investment strategies governance mechanism hand collected annual reports different regression models used determine impact investment human structural capital corporate governance features market performance ibs findings paper finds investments knowledge resources human capital particular significantly positive impact market value ibs results reveal ibs strategy rely long term human capital accumulation seen idiosyncratic problem solving knowledge capital based market measure paper finds role duality significant positive impact size advisory board opposite effect market value research limitations implications study includes ibs ignores islamic financial services providers takaful insurance companies study leaves chasm filled future researchers practical implications findings may serve useful input islamic bankers regulators apply knowledge management institutions furthermore dominant role human capital also provides insight managers respect business performance levers originality value main contribution paper provide insight islamic banking business model using unique hand collected data set identify effect investments organisational resources bank governance market value financial crisis
paper propose efficient method salient region detection first image decomposed using superpixel segmentation groups similar pixels generates compact regions based upon generated superpixels similarity regions calculated benefiting color location histogram intensity area information region well community identification via complex networks theory segmented image contrast distribution complex networks based saliency maps generated using mentioned features saliency maps used create final saliency map applicability effectiveness consistency proposed approach illustrated conducting experiments using publicly available datasets tests used compare proposed method state art methods reported results cover qualitative quantitative assessments demonstrate approach outputs high quality saliency maps mostly achieves highest precision rate compared methods
purpose present study analyze mother child collaborative play children autism spectrum disorders asd compared children syndrome typical developing children children asd often described deficient play skills particularly symbolic domain caregivers involvement child play activities increases structural complexity playing typically developing children children disabilities participants included mothers children asd syndrome typical development mother child play sessions analyzed using coding system exploratory symbolic play results indicated children asd showed exploratory play compared children groups significant differences emerged three groups child symbolic play mother play findings discussed relation debate functional symbolic play children asd relation importance setting age play assessment
aimrapid pacing regularly used model induce heart failure dogs aim study evaluate handling left ventricular contractile response administration compared exercise well oxygen consumption mechanical efficiency methodsfifty three mongrel dogs instrumented measure pressure fractional shortening regional wall thickening coronary blood flow contractile reserve measured isoproterenol intravenous administration assess function sarcoplasmic reticulum post extrasystolic potentiation pesp uptake measured graded treadmill test performed baseline separate group animals myocardial performance oxygen consumption measured using wide range loading conditions resultsleft ventricular contractility significantly decreased upon cessation pacing contractile response isoproterenol blunted compared preserved response post extrasystolic potentiation slightly increased maximal velocity max uptake unchanged contractile response exercise attenuated external work reduced whereas oxygen consumption preserved provoking reduced mechanical efficiency conclusionforty eight hours provokes reversible dysfunction function response exogenous preserved compatible intracellular functional remodelling counteract overload provoked left ventricular dysfunction accompanied reduced contractile reserve unchanged oxygen consumption illustrating alteration oxygen utilization
mechanochemistry branch solid state chemistry analyzes processes occur solids due application mechanical energy energy supplied high energy milling mechanochemical approach belongs group procedures intensify course processes producing various surface bulk defects treated solids accumulated energy acquired milling utilized subsequent processes principle potential mechanochemistry applied cases economic demand high temperatures well wet processes consideration several applications mechanochemistry illustrated demonstrate potential apparently distinct fields like extractive metallurgy materials engineering medicine
simple linear regression functional errors variables eiv model revisited different perspective problem addressed using small sigma model instead large sample theory general analysis developed study slope estimator minimizes family objective functions least squares fit maximum likelihood estimator minimizers special functions general formulas higher order terms bias variance mean square error derived accordingly two efficient estimators proposed implementing pre post bias elimination techniques numerical tests confirm superiority proposed estimators others
era highly active antiretroviral therapy haart hiv associated neurocognitive disorders hand persist infected individuals adequate immunological virological status risk factors cognitive impairment include hepatitis virus infection host genetic factors predisposing hand early establishment virus cns persistence haart thus cns important reservoir hiv microglial cells permissive hiv nlrp inflammasome associated genes found expressed brains hiv infected persons contributing brain disease inflammasomes triggered alarmins danger associated molecular patterns damps directly stimulate production proinflammatory mediators glial cells contribute blood brain barrier injury induction release various proteases allow passage infected macrophages trigger release primed cells amongst alarmins involved hiv induced neuropathogenesis high mobility group box hmgb particular interest neurocognitive alterations recently associated dysregulation axis cns leading induction neuronal apoptosis decrease synaptic function neuroinflammation specific biomarkers including hmgb anti hmgb antibodies identified cerebrospinal fluid patients hand correlated immune activation identifying early stage neurocognitive impairment precedes changes metabolites detected magnetic resonance spectroscopy moreover hmgb plays crucial role hiv persistence dendritic cells constitution viral reservoirs review mechanisms whereby alarmins contribute hiv induced cns inflammation neuropathogenesis discussed
objective revise conversion disorder scale establish psychometric properties revised scale methods case control study conducted february june government college university lahore pakistan comprised schoolchildren children conversion disorder order generate items revised version conversion disorder scale seven practising mental health professionals consulted list items finalised expert ratings empirical validation scale items administered participants factor analysis conducted results participants schoolchildren controls group children conversion disorder clinical group results factor analysis revealed five factors swallowing speech symptoms motor symptoms sensory symptoms weakness fatigue mixed symptoms retention items revised version conversion disorder scale concurrent validity revised scale found significantly high similarly discriminant validity scale also high clinical control groups significant difference scores cronbach alpha scale alpha item total correlation ranged sensitivity specificity analysis indicated revised conversion disorder scale sensitive predicting conversion disorder specificity showed scale accurate specifying participants control group conclusion revised version conversion disorder scale reliable valid tool used screening children conversion disorder
abnormal expression function myelin related proteins contribute nervous system dysfunction associated neuropsychiatric disorders however underlying mechanism remains unclear found breast carcinoma amplified sequence bcas basic protein abundant brain expressed specifically oligodendrocytes schwann cells expression level decreased demyelination suggests bcas novel myelin associated protein bcas knockout mice displayed schizophrenia like behavioral abnormalities tendency toward reduced anxiety like behaviors moreover found loss bcas specifically induced hypomyelination expression inflammation related genes brain observations provide novel insight functional link oligodendrocytes inflammation abnormal behaviors
schizophrenia patients impaired performance abnormal brain activation facial emotion recognition may represent marker genetic liability schizophrenia however remains unclear whether impairment specific recognizing emotion faces instead attributable generalized dysfunction current study aimed distinguish specific generalized neural dysfunction underlying impaired facial emotion recognition schizophrenia examine associations genetic liability twenty eight schizophrenia patients nonpsychotic first degree relatives community controls underwent functional magnetic resonance imaging making judgments either emotion age emotional faces patients performance deficits emotion age discrimination conditions compared relatives controls relatives intact performance patients hypoactivation compared controls across conditions mainly medial prefrontal cortex unlike controls patients demonstrated failure recruit dorsomedial prefrontal cortex region involved social cognition decision making relatives pattern recruitment intermediate patients controls compared controls relatives greater deactivation regions associated default mode network patients similar findings age discrimination common patterns performance deficits activation abnormalities emotion age discrimination schizophrenia suggest generalized cognitive impairment notably social cognition decision making contributes impaired facial emotion recognition similar functional activation patterns relatives despite intact performance suggest brain activation may represent sensitive marker genetic liability behaviour hyperdeactivation default mode network regions relatives may represent cognitive inefficiency compensatory mechanisms help maintain intact performance
study propose self tuning interval type fuzzy proportional derivative plus proportional integral stitfpd controller consists two fuzzy processors first itfpd controller parallel combination itfpd controller itfpi controller used main controller second tuning mechanism type fuzzy logic system tfls used parameters tuning tuning mechanism generates updating factors update output scaling factors sfs output membership functions mfs degree uncertainty input mfs proposed stitfpd controller implemented practically based microcontroller controlling overhead crane system test established using hardware loop hil simulation practical results show proposed stitfpd controller improves significantly performance wide range system uncertainties
analysis design performance conductor backed coplanar waveguide cbcpw moisture sensor described sensor used determine moisture content per cent oil palm fruit agricultural products sensor consists three parts coupling system representing transition coaxial line cbcpw two layer structures cbcpw sensing area semi infinite three layer cbcpw structure relationship scattering parameter attenuation sensor moisture content sample developed reflection transmission phenomena sensor structure represented signal flow graph simplified use non touching loop rules calculation based quasi transverse electromagnetic mode approximation work also studies effect thickness protective layer size gap conducting line upper ground plane sensitivity dynamic range sensor close agreement theoretical prediction experimental results obtained sensitivity accuracy sensors unit wet basis respectively sensor suitable development complete instrument used quality assessments oil palm fruit agricultural products
interpersonal deception dynamic process participating individuals adjust adapt behaviors deception proceeds using theme demonstrate deceptive communication group settings highly patterned examine patterning behavior using strategy focused lens interpersonal deception theory buller burgoon commun theory correlation regression analyses suggest deceivers tend strategically assertive carry deception group settings individuals suspicious deception tend engage probing behavior ostensibly attempting confirm suspicions findings demonstrate value analyzing deceptive behavior terms patterning gain greater insight complex deception process
objectives high bone mass hbm associated radiographic knee osteoarthritis partly mediated increased bmi pelvic enthesophytes hip osteophytes suggestive bone forming phenotype aimed establish whether hbm associated radiographic features non weight bearing hand joints whether demonstrates bone forming phenotype methods hbm cases bmd scores compared family controls blinded assessor graded hand radiographs osteophytes joint space narrowing jsn subchondral sclerosis index distal interphalangeal joint dipj carpometacarpal joint cmcj using established atlas analyses used random effects logistic regression model adjusting priori age gender mediating roles bmi bone turnover markers btms explored adjustment results hbm cases mean age years female controls years female included osteophytes grade common hbm dipj cmcj adjusted respectively differences seen jsn adjustment bmi failed attenuate ors osteophytes hbm cases controls dipj cmcj adjustment btms concentrations lower amongst hbm cases attenuate ors conclusions hbm positively associated non weight bearing joints independent bmi hbm associated characterised osteophytes consistent bone forming phenotype rather jsn reflecting cartilage loss systemic factors genetic architecture govern hbm may also increase bone forming risk authors published elsevier inc open access article license
study proposes application implementation new power factor correction pfc variable slope ramp small wind power system without input voltage sensing circuits external control components current shaping loop hardware description variable slope ramp simplifies complexity integrated circuit realization low resolution analog digital converters achieves high power factor multi three phase converters wind power systems small wind power system tested verify performance proposed pfc control highest achieved power factor reaches
article deals electronic implementation dynamical system comprises multiple scrolls regarded unstable dissipative system system dissipative one components unstable two proposed electronic circuit implemented resistors capacitors comparators capability generate two three scrolls
assessed correlates obsessive compulsive ocpd schizotypal spd borderline bpd personality disorders obsessive compulsive disorder ocd patients found ocd patients ocpd exhibit higher rates hoarding bipolar disorders increased severity hoarding symmetry lower prevalence unacceptable thoughts involving sex religion less non planning impulsivity conversely ocd patients spd displayed frequently bipolar disorder increased severity depression ocd neutralization greater prevalence low order behaviors touching lower low planning impulsivity greater behavioral compulsivity finally exploratory analyses ocd patients bpd exhibited lower education higher rates several comorbid psychiatric disorders greater frequency compulsions involving interpersonal domains reassurance seeking increased severity depression anxiety ocd dimensions symmetry hoarding motor non planning impulsivity greater cognitive compulsivity findings highlight importance assessing personality disorders ocd samples elsevier ltd rights reserved
clause equal satisfied least one literal assigned one literal assigned max nae sat given set boolean variables set clauses asks find assignment equal satisfied clauses maximized max nae sat turns max nae sat clause contains literals max nae sat approximated respectively little done terms algorithm design approximate max nae sat paper propose local search algorithm approximate max nae sat show max nae sat approximated within polynomial time equal moreover extend algorithm max nae sat approximate max nae sat clause contains least literals
fast cosine transform increasingly used data compression image coding signal filtering feature extraction order implement transform parallel processing environment signal flow graph ifct modelled among several interconnection networks parallel processing omega network popular due property universality paper models ifct algorithm map multiprocessors connected omega multistage interconnection network min communication complexities involved mapping estimated speedup efficiency performance omega network based multiprocessors evaluated
protein coupled receptors gpcrs regulate many animal behaviors gpcr signaling mediated agonist promoted interactions gpcrs heterotrimeric proteins gpcr kinases grks arrestins elucidate role grks regulating gpcr mediated behaviors utilized genetic model system caenorhabditis elegans studies demonstrate grk loss function strains egg laying defective contain low levels serotonin high levels metabolite hydroxyindole acetic acid hiaa egg laying defect could rescued expression wild type catalytically inactive grk selective expression grk hermaphrodite specific neurons addition inhibition metabolism also rescued egg laying defect furthermore demonstrate amx primary monoamine oxidase metabolizes elegans also found grk loss function strains abnormally high levels amx compared wild type nematodes interestingly grk also found interact promote phosphorylation amx additional studies reveal hiaa functions inhibit egg laying manner dependent receptor ser protein goa results demonstrate grk modulates metabolism regulating amx function hiaa may function ser signaling pathway
realized multifunctional aerial display aerial image polarization processing display formed aerial imaging retro reflection changing polarization modulation patterns switch three layered display secure display
flavonoids baicalin dihydroxy phenyl benzopyran one beta glucuronic acid aglycone baicalein found edible medicinal plants scutellaria baicalensis georgi oroxylum indicum kurz abundant quantities antioxidant anti inflammatory effects flavonoids demonstrated various disease models including diabetes cardiovascular diseases inflammatory bowel diseases gout rheumatoid arthritis asthma neurodegenerative liver kidney diseases encephalomyelitis carcinogenesis flavonoids almost toxicity human normal epithelial peripheral myeloid cells antioxidant anti inflammatory activities largely due abilities scavenge reactive oxygen species ros improvement antioxidant status attenuating activity kappa suppressing expression several inflammatory cytokines chemokines including monocyte chemotactic protein mcp nitric oxide synthase cyclooxygenases lipoxygenases cellular adhesion molecules tumor necrosis factor interleukins review summarize antioxidant anti inflammatory effects baicalin baicalein molecular mechanisms chemopreventive chemotherapeutic applications treatment inflammatory related diseases elsevier masson sas rights reserved
objective compare perception students usefulness interactive tutorials clinically oriented problem solving tutorials methods cross sectional study carried january november bahria university medical dental college karachi perception medical students usefulness interactive tutorials clinically oriented problem solving tutorials acquired questionnaire distributed medical students completed first two years studies responses various aspects learning physiology acquired scale poor good excellent learning abilities acquired skills compared terms extent great extent data analysed using spss results hundred students initially enrolled complete response obtained females significant difference understanding structure function clinically oriented problem solving tutorials students preferred clinically oriented problem solving tutorials far understating difficult concepts concerned presentation skills improved interactive tutorials whereas clinical reasoning skills acquired clinically oriented problem solving tutorials found significantly better tutorials helped learning content physiology conclusion clinical reasoning skills acquired clinically oriented problem solving tutorials helped better understanding structure functions
aims compare patient characteristics rates costs medically attended falls among patients parkinson disease probable plus neurogenic orthostatic hypotension noh materials methods marketscan commercial medicare supplemental databases january december used identify probable noh patients first medical prescription claim suggesting diagnoses served index date baseline characteristics post index cause fall related healthcare utilization costs compared patient groups results total noh patients identified compared patients noh patients older years comorbidities pre post index date noh patients medically attended fall patients respectively fallers groups similar numbers medically attended falls months pre index mean noh fallers falls post index compared patients noh patients fall related emergency department visits hospitalizations non office visit outpatient services adjusted total post index medical costs falls total cause costs higher noh patients limitations study limitations icd diagnosis code noh combination diagnoses confounding conditions excluded served proxy noh diagnosis also rate falls associated costs cohorts might reported medically attended falls evaluated conclusions noh patients higher prevalence pre existing comorbidities higher rate medically attended falls alone leading increased costs care
sought identify relationship individual psychological factors related four profiles intimate partner violence ipv among pregnant adolescent couples ipv male ipv victim female ipv victim mutual ipv associations differ sex using data longitudinal study pregnant adolescents partners couples used multivariate profile analysis using multivariate analysis covariance within subjects effects compare ipv groups sex relationship psychological factors analyses conducted couple level ipv groups subjects couple level variable sex within subjects variable allowed model compare outcomes partners controlling correlated nature data analyses controlled age race income relationship duration gestational age among couples ipv male ipv victim mutual ipv female ipv victim relationship psychological factors differed ipv group overall attachment anxiety attachment avoidance relationship equity perceived partner infidelity depression stress hostility differed ipv profile attachment anxiety equity depression stress significant ipv profile sex interaction couples mutual ipv least healthy relationship psychological characteristics couples ipv healthiest characteristics females mutually violent relationships particularly high risk couple level interventions focused relational issues might protect young families developing ipv behaviors wiley periodicals inc
study examined whether diagnostic classification mental health developmental disorders infancy early childhood revised edition zero three parent infant relationship global assessment scale pir gas applicable six european countries contributes identification caregiver infant toddler dyads abusive relationship patterns sample consisted dyads children ages ranging months sixty four dyads recruited community settings without known violence problems dyads recruited clinical settings already identified violence problems risk violence problems classify dyads pir gas categories caregiver child interactions video recorded coded observational scales appropriate child age test whether pir gas allows reliable identification dyads abusive relationship patterns pir gas ratings compared scores international society prevention child abuse neglect ispcan child abuse screening tool parental version icast runyan etal questionnaire measuring abusive parental disciplinary practices found pir gas ratings differentiated general clinical sample dyads abusive patterns relationship identified pir gas icast interrater reliability pir gas ranged moderate excellent value broader use tools promote early identification families risk infant toddler abuse neglect discussed
introduction efficacy safety tocilizumab tcz humanized anti interleukin receptor monoclonal antibody patients polyarticular course juvenile idiopathic arthritis pjia demonstrated clinical trials area covered literature search undertaken public domain data included regulatory submission leading approval tcz treatment pjia european union united states japan also presented tcz patients weighing provided pharmacokinetic exposure comparable tcz patients pharmacodynamic reactive protein erythrocyte sedimentation rate soluble efficacy outcomes comparable tcz patients proportions patients achieving jia acr responses week increased higher exposure meansd min quartile quartile adverse event rate increase increased exposure data support weight based dosing regimens expert commentary biologics improved outcomes patients pjia inadequate response conventional therapy tcz likely become increasingly important treatment option management pjia
drought natural climatic phenomenon occurs throughout world impacts many sectors society help decision makers reduce impacts drought important improve monitoring tools provide relevant timely information support drought mitigation decisions given drought complex natural hazard manifests different forms monitoring improved integrating various types information remote sensing climate timely region specific identify droughts occurring vegetation drought response index canada vegdri canada recently developed drought monitoring tool canada vegdri canada extends initial vegdri concept developed conterminous united states broader transnational coverage across north america vegdri canada models similar developed united states integrating satellite observations vegetation status climate data biophysical information land use land cover soil characteristics environmental factors collectively different types data integrated hybrid vegdri canada isolate effects drought vegetation twenty three weekly vegdri canada models built growing season april september weekly analysis data using regression tree based data mining approach year time series vegdri canada results produced using models output validated randomly selecting historical data well holdout year unseen data across growing season pearson correlation ranged case study also conducted evaluate vegdri canada results prairie region canada two drought years one non drought year three weekly periods growing season early mid late season comparison vegdri canada map canadian drought monitor cdm independent drought indicator showed vegdri canada maps depicted key spatial drought severity patterns two targeted drought years consistent cdm addition vegdri canada compared canola yields prairie provinces regional scale period evaluate indices applicability monitoring drought impacts crop production result showed vegdri canada values relatively higher correlation canola yield nonirrigated croplands canadian prairies region areas drought typically limiting factor crop growth showed negative relationship southeastern prairie region water availability less limiting factor cases hindrance crop growth waterlogging occurs initial results demonstrate vegdri canada utility monitoring drought related vegetation conditions particularly drought prone areas general results indicated vegdri canada models showed sensitivity known agricultural drought events canada year period mainly nonirrigated areas
recently developed models psychopathy include traits fearlessness boldness invulnerability section iii diagnostic statistical manual mental disorders dsm includes well psychopathy specifier modeled traits purpose current study test empirically convergent discriminant validity psychopathic personality inventory revised ppi triarchic psychopathy measure tripm elemental psychopathy assessment epa personality inventory dsm pid respect relationship one another traditional measures psychopathy antisocial personality disorder measure factor model participants samples community adults indicated engaged criminal activities results indicated good convergent discriminant validity ppi tripm epa pid psychopathy specifiers well relationships measure factor model quite distinct relationships obtained traditional measures antisocial personality disorder psychopathy however concerns raised respect reliance reverse coded items assessment components psychopathy
atrial fibrillation mainly triggered arrhythmogenic foci originating atrial myocardial extensions mes pulmonary veins pvs aim study evaluate endocardial voltage maps pvs surrogate parameter extent mes subjects ultra high density mapping system sixty four bipolar electrograms recorded simultaneously orion mini basket catheter placed pvs consecutive patients paroxysmal persistent undergoing isolation pvi rhythmia system conjunction orion mini basket catheter utilized create bipolar electro anatomic reconstruction left atrium pvs mean patients age years paroxysmal persistent mean endocardial bipolar voltages pvs follows right superior right inferior left superior left inferior pvs detectable endocardial signals pvs total pvs revealed non uniform arrangement mes area mes significantly larger superior pvs compared inferior pvs statistical differences terms mes length found among pvs according type pilot study using ultra high resolution electro anatomical mapping system endocardial voltage maps pvs surrogate parameter mes among patients well correspond previous data histopathological studies
energy atmosphere category leed accounts total points heavily depends standards ansi ashrae iesna difficulties arise leed implemented different countries varying degrees similarity local standards standards countries standards may range non existent locally developed instruments standards preferred existing codes standards regulations effect india abu dhabi turkey used relevant category leed reviewed relative counterparts found india ecbc combines local conditions international standards abu dhabi esma adqcc make sure geographic conditions prevalent part world reflected codes regulations turkey new bep code constitutes significant step towards energy conservation study shows standards effect subject countries adapted standards local conditions different stages development variety quality substance coverage standards make difficult implement green building certification systems countries elsevier rights reserved
study study conducted determine effects geriatric foods utilizing healthy geriatric cats years initially cats fed control food day pre feeding period blocked age gender body fat percentage randomly assigned foods experimental geriatric food lams active maturity royal canin mature purina one senior protection formula day testing period chemistry screens microalbuminuria evaluated day day along dual energy ray absorptiometry dexa scan day cats fed foods maintained weight body fat content throughout study day cats fed food reduced bone mineral content cats fed food reduced lean cats fed food tended lower percentage cats renal damage compared cats fed food vital organ measures cats fed food lower however cats fed food weighed less less fat compared cats fed food cats fed food also less fat combining data studies plotting increasing lysine calorie ratio versus lean loss corresponding ratio strong linear relationship could detected line representing variation lean loss moderate linear relationship detected bone mineral content decreased increasing crude protein concentration studies suggest feeding food reduced protein phosphorus higher levels polyunsaturated fatty acids well antioxidants improved markers kidney function compared commercial formulas additionally increasing lysine calorie ratio prevented loss lean body mass geriatric cat provided similar response high protein foods
right ventricular function difficult assess owing complex morphology structure function right ventricle comprises three compartments inlet apex outlet contracting peristaltic motion inflow outflow chamber tightly linked left ventricular function pulmonary circulation interventricular septum myocardium inside pericardial envelop relation function symptom occurrence exercise capacity prognosis wide variety cardiac diseases emphasizes usefulness routine assessment evaluation largely carried echocardiography daily clinical practice despite important limitations inherent two dimensional imaging multiple views numerous parameters allow clinicians integrate function clinical decision making process recent modalities echocardiography myocardial deformation three dimensional imaging exercise echocardiography promising tools assessment cardiac magnetic resonance imaging provides unique opportunity image motion three dimensions without limitation echogenicity therefore cardiac magnetic resonance imaging taking growing place assessment wide variety cardio pulmonary diseases pulmonary hypertension ischemia arrhythmogenic right ventricular cardiomyopathy hypertrophic cardiomyopathy heart failure congenital heart diseases integrating complex interplay ventricles pulmonary circulation review discuss latest results standard novel techniques allowing assessment function echocardiography cardiac magnetic resonance imaging provide clinicians facing therapeutic challenges comprehensive overview right heart function
offer use slow wave structures swss monitoring parameters absorbing coatings widely used stealth technology shown resonant frequencies factor sws section placed parallel monitored coating strongly depend electric magnetic properties coating dependence converted coating parameters reading
principles computer programming pcp compulsory subject degree courses offered first year study unikl miit seven courses taking subject compulsory subject regardless technical arts management disciplines study identify weak students technical disciplines study also identifies nontechnical disciplines students potential results obtained showed students ability logical thinking problem solving skills performance analysis based different course disciplines done identify whether course discipline influence result observation showed first year students influence disciplines almost equal chances score subject contradicts students perceptions especially arts management disciplines even students technical disciplines taken subject seriously continuity programming subjects enrolled therefore need equip strong programming skills results shown large number students technical disciplines ready pursue higher levels programming subjects however still small group students yet reconsider choice course disciplines
recent years number mobile device significantly increase high bandwidth led demand mobile hoc network manet network offers mobile access users minimal configuration operate nonetheless salient feature requires flexibility cooperation users increases network vulnerability black hole attack therefore improved security approach needed maintain optimal network performance black hole attack severely threaten network exploiting vulnerability route request rreq discovery process routing protocols hoc demand distance vector aodv intruders able utilise loophole carry malicious behaviours rreq process essential mechanism within aodv result genuine rreq packets exploited erroneously relayed false node demand routing protocols act binding element networks common target security attack paper presents review black hole attack mobile nodes subsequently proposes new mechanism alleviate issue aodv routing protocol chosen base protocol inherently similar types demand routing protocol dsdv dsr fact routing protocol follows request reply method may utilise scheme mitigate issue includes proactive routing protocol olsr proposed scheme node capable detect isolate malicious node local region appropriate implementation
transient effects occurring superconducting accelerator circuit correctly simulated models consistently account electrothermodynamic coupling magnets protection systems remaining network present framework based idea cosimulation core component coupling interface exchanging information independent models within framework simulate selected parts magnet electrical network combining appropriately different commercial tools modularity gives possibility integrating new tools framework provide insights different physical domains mechanics fluid dynamics workflow applied field circuit coupling lhc main dipole magnet
network information technology product combination communication computer technology computer network interconnect world dispersed independent computers accordance network protocol rapid development information technology home abroad developed countries parts developing countries strengthening national information infrastructure several gold projects information technology representative gradually deeper forming unprecedented development entire information network technology globalization construction market intensifying competition construction management requires higher information technology relatively backward china construction industry important practical significance clearly recognize entire network computing model technology developments properly apply construction project management
objective evaluate relationship hospital teaching intensity medicare payments perioperative outcomes background several emerging payment policies penalize hospitals low value healthcare teaching hospitals may disadvantage given perception deliver care less efficiently methods using medicare provider analysis review files studied patients age years underwent abdominal aortic aneurysm aaa repair pulmonary resection colectomy patients hospitals categorized quintiles teaching intensity major major minor minor nonteaching hospitals based resident bed ratio risk adjusted day medicare payments price standardized account graduate medical education payments disproportionate share costs regional wage index adjustments risk adjusted perioperative outcomes also assessed results comparing risk adjusted medicare payments per episode surgery major teaching hospitals expensive nonteaching hospitals aaa repair expensive pulmonary resection expensive colectomy however accounting social subsidies regional variation medicare spending risk adjusted medicare payments statistically different major teaching hospitals nonteaching hospitals aaa repair pulmonary resection statistically significant attenuated difference persisted colectomy major teaching hospitals generally higher risk adjusted rates serious complications readmissions lower risk adjusted rates failure rescue day mortality nonteaching hospitals conclusions price standardization account intended differences medicare spending risk adjusted medicare payments episode surgical care similar teaching hospitals nonteaching hospitals three complex inpatient operations
aim paper critically review prominent decomposed fuzzy pid control structures structural construction output control laws controllers discussed merits drawbacks highlighted based critical discussions new structure fuzzy pid controller proposed based cascaded structure yields simpler design flow parameters tuning advantages proposed fuzzy pid structure reduction tuning parameters rules fuzzy controller addition proposed structure allows usage signed distance method application method reduces computation burden significantly power inverter regulation needs fast precise computations
combination sorption capacity reaction enthalpy melting temperatures around available industrial waste heat solar source high thermal efficiency compared others salt hydrates makes strontium bromide two respective hydrates potential material low temperature energy storage building applications considered among suitable materials low thermochemical sorption energy storage application tsoukpoe due high energy storage density end user temperature strontium bromide simultaneously considered phase change thermochemical material short analysis general physical chemical properties thermodynamics melting temperature density sorption kinetics exergy thermal conductivity specific heat capacity permeability highlights advantageous properties review use strontium bromide pure modified form extended applications building structure composite design thermal storage heating cooling usefulness disadvantages use closed open processes discussed possible solutions issues presented proposed
aim paper present digital implementation direct torque control dtc induction motor constant switching frequency using field programmable gate array fpga component fpga used order overcome digital signal processing control engineering dspace limitations sequential processing increase sampling time conventional direct torque control cdtc presents disadvantages torque stator flux ripples stator current distortions due variable commutation frequency inverter overcome conventional dtc limitations switching frequency imposed using space vector modulation svm hardware implementation proposed take advantages fpga digital control field electrical machines real time reduction execution time adopting parallel processing possibility implementing complex efficient algorithms exploiting parallel computing performances direct torque control space vector modulation evaluated digital simulation using toolbox xilinx system generator xsg implementation results fpga found proposed control yields high performances term ripples execution time
working alliance empathy believed important components counseling although studies empirically tested recently conducted randomized controlled trial brief motivational reduction counseling failed increase number participants made quit attempt comparison usual care brief advice quit negative findings could due nonspecific factors secondary analysis used subset participants test whether comparison usual care brief telephone based motivational reduction counseling predicted greater working alliance empathy whether changes nonspecific factors predicted increased probability month follow whether counseling affected probability via working alliance empathy mediation findings similar active counseling conditions motivational reduction versus usual care comparison usual care active counseling predicted greater working alliance empathy greater working alliance predicted greater probability surprisingly greater empathy predicted decreased probability month follow working alliance empathy mediated active counseling effects probability one explanation motivational reduction interventions failure influence qas comparison usual care working alliance empathy opposing effects quitting analyses illustrate testing nonspecific factors mediators help explain treatment failed
performing systematic literature review slr turbulent field software engineering brings different obstacles uncertainties commonly used guidelines performing slr field adapted health sciences presented kitchenham charters paper follows kitchenham three phases review process fulfils findings observations recommendations influential authors field process slr observed perspective appliance field supplemented important precautious measures undertaken authors performing thus paper aims present state art performing slr
paper presents fast concurrent binary search tree algorithm achieve high performance contention algorithm divides update operations within eager abstract access returns rapidly efficiency reason lazy structural adaptation may postponed diminish contention achieve high performance read workloads features rebalancing mechanism guarantees read operations searching element execute lock free evaluate contention friendly binary search tree using synchrobench benchmark suite compare synchronization techniques specifically compare performance five state art binary search trees use locks transactions compare swap synchronization intel xeon amd opteron oracle sparc results show tree efficient trees double throughput existing lock based trees high contention
background localized early stage extra nodal marginal zone lymphoma mzl presents heterogeneous organ involvement treated various modalities including resection radiotherapy systemic therapy report long term outcome large cohort extra nodal mzl assess impact patient disease characteristics organ site treatment strategy disease control survival patients methods identified consecutive patients stage iie mzl referred memorial sloan kettering cancer center pathology reviewed hematopathologists institution patient disease factors well treatment types analyzed association relapse free survival overall survival cumulative incidence relapse results median follow treatment years five year relapse free survival overall survival respectively cumulative incidence disease specific death years radiotherapy alone initial treatment patients followed surgical resection observation immunotherapy chemotherapy initial treatment type primary disease site number involved sites significant factors multivariable analysis relapse except thyroid higher risk relapse strategies antibiotics topical therapies associated higher risk relapse compared radiation therapy crude rate transformation pathologically confirmed large cell lymphoma patients conclusion overall cause specific survival high early stage extra nodal mzl curative intent treatment led fewer relapses reduced need salvage stomach cases lower risk relapse anatomic primary sites study supports use local therapies treat stage iie mzl
introduction allophilia may defined positive attitudes toward different groups aim study translate validate allophilia scale spanish population method participants individuals spain questionnaires measure prejudice toward north african people stress empathy used analyze convergent divergent validity allophilia scale results confirmatory factor analysis showed items questionnaire fit model five factors corresponding dimensions proposed original authors affection comfort kinship engagement enthusiasm inter related cronbach alpha allophilia scale five factors high addition found different sub scales allophilia scale related variables prejudice toward north african people cognitive emotions behaviours stress interaction resources identity empathy discussion light results conclude questionnaire methodologically valid used scientific community measure cooperative participatory intergroup behaviour complement traditional measures prejudice negative intergroup behaviours
least angle regression promising model selection method differentiates conventional stepwise stagewise methods neither greedy slow closely related norm optimization advantage low prediction variance sacrificing part model bias property order enhance model generalization capability paper propose efficient least angle regression algorithm model selection large class linear parameters models purpose accelerating model selection process entire algorithm works completely recursive manner correlations model terms residuals evolving directions pertinent variables derived explicitly updated successively every subset selection step model coefficients computed algorithm finishes direct involvement matrix inversions thereby relieved detailed computational complexity analysis indicates proposed algorithm possesses significant computational efficiency compared original approach well known efficient cholesky decomposition involved solving least angle regression three artificial real world examples employed demonstrate effectiveness efficiency numerical stability proposed algorithm
background folate deficiency independent risk factor congenital heart disease chd however maternal plasma folate level paradoxically good diagnostic marker genome wide surveys identified variants nonfolate metabolic genes associated plasma folate level suggesting genetic polymorphisms potential risk factors chd methods examine effects folate concentration related variations chd risk han chinese population performed independent case control studies including total patients chd control subjects expression fidgetin fign detected human cardiovascular decidua tissue specimens quantitative real time polymerase chain reaction western blotting molecular mechanisms investigated luciferase reporter assays surface plasmon resonance chromatin immunoprecipitation fign interacting proteins confirmed tandem affinity purification coimmunoprecipitation proteasome activity metabolite concentrations folate pathway quantified commercial proteasome activity assay immunoassays respectively results variant intron fign gene associated significant reduction chd susceptibility allele genotype analysis combined samples indicated chd risks individuals carrying heterozygous homozygous genotypes reduced odds ratio confidence interval respectively compared major genotype minor allele carriers decreased plasma folate levels exhibited significantly increased fign expression transcription suppressor creb bind alternative promoter fign isoform mechanistically increased fign expression led accumulation reduced folate carrier dihydrofolate reductase via inhibition proteasomal degradation promoted folate absorption metabolism conclusions report previously undocumented finding decreased circulating folate levels induced increased folate transmembrane transport utilization determined fign intronic variant serves protective mechanism chd results may explain circulating folate levels good diagnostic value
background providing correct complete counseling use oral contraceptives ocs central securing autonomy women child bearing age powerful proven tool social change pharmacists many developing countries egypt involved dispensing times prescribing pharmaceuticals including oral contraceptives readily available without prescription objectives predict egyptian community pharmacists counseling oral contraceptives utilizing theoretical framework guided theory planned behavior tpb methods cross sectional self administered survey completed random sample community pharmacists alexandria egypt determine attitudes behaviors regarding counseling ocs multiple regression used predict self reported counseling oral contraceptives function tpb related constructs six factors perceived importance profit dispensing ocs pharmacy revenue number hours worked age gender pharmacy practice degree marital status pharmacist results pharmacists invited complete survey participated pharmacists indicated talked slightly higher proportion women importance taking ocs time daily topics day start taking ocs side effects dose ocs missed pharmacists reported counseling oral contraceptives positively associated perception women welcomed pharmacist initiated counseling beta perceived adequacy time available counsel women ocs beta perceived number women asked help selecting without providing prescription past week beta pharmacists reported women welcoming pharmacists initiating counseling associated pharmacists reported percent asked pharmacists advice last women seeking male pharmacists less likely female pharmacists report women welcomed pharmacist initiated counseling conclusions tpb appears help predict pharmacists counseling need prepare pharmacists frequently requested assist women selection oral contraceptive interventions would facilitate women requests information may valuable increase pharmacists counseling oral contraceptives future qualitative observational studies needed assess complexities counseling oral contraceptives developing countries elsevier inc rights reserved
background intensive insulin treatment bothersome obese patients type diabetes mellitus high insulin dosages increase weight gain risk hypoglycemia glucagon like peptide receptor agonists decrease insulin need cause weight loss reduce risk hypoglycemia limited data effect exenatide obese diabetics intensive insulin regimens methods retrospective case series report clinical outcomes obese morbidly obese patients uncontrolled type diabetes mellitus age years body mass index hbac high dose unit intensive insulin exenatide twice daily added mean follow period months intensive insulin regimens continued patients others switched basal insulin follow results follow mean hbac levels patients significantly improved along significant decrease body mass index total insulin need baseline insulin dosages significantly higher intensive regimen group demographical clinical characteristics similar significant difference present groups regarding alterations hbac body mass index reduction total insulin dosages conclusion add exenatide appears rational treatment modality uncontrolled obese patients type diabetes mellitus despite intensive insulin regimens prospective randomized studies longer follow periods recommended
background aim impact nocturia getting night void health related quality life hrqol often estimated study investigated relative burden terms hrqol utilities nocturia real world setting methods patient data collected two surveys nocturia specific cross sectional survey physicians patients dsp general population health survey hsfe utilities productivity work productivity activity index impact nocturia symptoms nocturia impact diary overactive bladder questionnaires assessed number voids robust linear regression model propensity score weights used control confounding factors estimating utilities results physician recorded data available patients across germany spain france included patient reported outcomes total controls drawn two surveys compared nocturia patients deterioration hrqol associated increasing number night time voids particular significant differences observed voids per night associated modest significant deterioration utility limitations cause nocturia multifactorial mostly elderly patients may several concomitant diseases authors tried adjust common ones may diseases unknown relationships included conclusions nocturia negatively affected hrqol patient utility clear effect seen already two voids per night every effort therefore made reduce nocturia bother threshold two voids per night
background attachment theory proven essential mental health including psychopathology development interpersonal relationships validated psychometric instruments measure attachment abound suffer shortcomings common traditional psychometrics recent developments multimodal fusion machine learning pave way new automated objective psychometric instruments adult attachment combine psychophysiological linguistic behavioral analyses assessment construct objective aim study present new exposure based automatic objective adult attachment assessment biometric attachment test bat exposes participants short standardized set visual music stimuli whereas immediate reactions verbal responses captured several computer sense modalities automatically analyzed scoring classification also aimed empirically validate two assumptions capacity measure attachment security viability using themes placeholders rotating stimuli methods total french participants general population assessed using adult attachment questionnaire aaq adult attachment projective picture system aap attachment multiple model interview ammi ground truth attachment security exposed three different bat stimuli sets whereas faces voices heart rate electrodermal activity eda recorded psychophysiological features skin conductance response scr bayevsky stress index behavioral features gaze facial expressions well linguistic paralinguistic features automatically extracted exploratory analysis conducted using correlation matrices uncover features associated attachment security confirmatory analysis conducted creating single composite effects index testing correlations attachment security stability theory consistent features across three different stimuli sets explored using repeated measures analysis variances anovas results total theory consistent correlations found exploration total significant correlations example attachment security measured aap correlated positive facial expressions ammi security father inversely correlated low frequency hrv attachment security partners measured aaq inversely correlated anger facial expression confirmatory analysis showed composite effects index significantly correlated security aap aaq ammi repeated measures anovas conducted individually theory consistent features revealed features significantly different values among responses three different stimulisets conclusions able validate two instrument core assumptions capacity measure attachment security viability using themes placeholders rotating stimuli future validation dimensions well ongoing development scoring classification algorithms discussed
paper prove lazer mckenna conjecture suspension bridge model higher dimension also discuss properties limiting problem related swift hohenberg equation
mechanism tacrine precognitive drug considered complex fully understood reported involve wide spectrum targets involving cholinergic gabaergic nitrinergic glutamatergic pathways review effect tacrine derivatives nmda receptors nmdar focus mechanism action biological consequences related alzheimer disease treatment findings indicate effect tacrine glutamatergic neurons direct indirect direct nmdar antagonistic effect often reported vitro studies however achieved high tacrine concentrations likely occur clinical conditions impact memory behavioral testing ascribed indirect effects tacrine caused influencing nmdar mediated currents via receptor activation leads inhibition activated potassium channels inhibition prevents membrane polarization leading prolonged nmdar activation subsequently long term potentiation considering findings conclude tacrine derivatives dual cholinesterase nmdars modulating activity may represent promising approach drug development diseases associated cognitive dysfunction alzheimer disease elsevier inc rights reserved
purpose investigate influence intensity telecommuting employee health design study design comprised longitudinal analysis employee demographic data medical claims health risk assessment data remote connectivity hours setting data prudential financial served setting subjects active employees ages years completed health risk assessment study subjects measures measures included telecommuting status intensity eight indicators health risk status obesity depression stress tobacco use alcohol abuse poor nutrition physical inactivity overall risk measure employee age sex race ethnicity job grade management status work location control variables analysis health risks determined nontelecommuters telecommuters working remotely hours per month longitudinal models health risk estimated controlling demographic job characteristics results telecommuting health risks varied telecommuting intensity nontelecommuters greater risk obesity alcohol abuse physical inactivity tobacco use greater overall risk least one telecommuting groups employees telecommuted hours per month significantly less likely nontelecommuters experience depression association telecommuting stress nutrition conclusion results suggest employees may benefit telecommuting opportunities
background purpose cervical artery dissection common cause stroke young people temporal profile stroke risk cervical artery dissection presenting without ischemia remains uncertain methods performed crossover cohort study using administrative claims data emergency department visits acute care hospitalizations using previously validated international classification diseases ninth revision clinical modification codes identified patients cervical artery dissection previous concurrent stroke transient ischemic attack diagnosis compared risk stroke successive week periods weeks dissection versus corresponding week period year later absolute risk increases calculated using mcnemar test matched data sensitivity analysis limited population patients presenting typical symptoms cervical artery dissection results identified patients dissection without ischemia absolute increase stroke risk confidence interval first weeks dissection compared time period year later absolute risk increase confidence interval weeks longer significant remainder week postdissection period findings similar sensitivity analysis identifying patients presented typical symptoms acute dissection conclusions risk stroke cervical artery dissection unaccompanied ischemia time diagnosis seems limited first weeks
objective evaluate levels calcium binding proteins skin patients psoriatic arthritis methods skin punch biopsies obtained patients psoriatic arthritis healthy control subjects semiquantified via immunohistochemistry semiquantitative polymerase chain reaction results study included biopsies nine patients psoriatic arthritis nine control subjects present visibly higher levels psoriatic plaques compared normal skin samples rna levels significantly higher peripheral region plaques compared central region conclusion may represent good therapeutic targets psoriasis psoriatic arthritis
leukemic transformation patients diagnosed polycythemia vera associated poor prognosis median survival exceeding months date cases post acute lymphoblastic leukemia reported year old female patient developed years met criteria diagnosis molecular study positive jakvf mutation due high risk features history deep vein thrombosis treated hydroxyurea moderate efficacy became anemic thrombocytopenic mild leukocytosis still blood bone marrow smears revealed blast cells respectively immunophenotyping blasts consistent diagnosis early precursor cell found positive jakvf mutation patient received induction regimen achieved complete remission negative minimal residual disease flow cytometry post chemotherapy study jakvf mutation positive patient remained remission months suitable donor searching initiated post extremely rare phenomenon due poor prognosis allogeneic stem cell transplantation considered fit patients achieved remission
solar thermal energy considered promising source drive air conditioning applications due good correlation supply demand present work examines feasibility novel low profile concentrated solar thermal collector provide medium temperature heat commercial buildings heating cooling purposes aiming redtice non renewable energy consumption levels best authors knowledge semi passive tracking concentrating platform employed collector represents significant improvement stationary internal tracking module remains fixed solar concentrating technology investigate real world viability collector design solar heating cooling system level techno economic performance analysis conducted using validated trnsys model solar heating cooling shc system includes proposed solar thermal collectors auxiliary heater double effect absorption chiller study proposed solar collectors employed supply thermal energy chiller offset building cooling demand thermal energy also used directly satisfy btiilding heating demand sufficient solar energy available auxiliary heater provides rest heating cooling demand annual solar fraction economic metrics total levelized costs used selection criteria among design options simulation results demonstrate specific collector area per cooling optimal storage tank specific volume sufficient cover load requirement building economic analysis indicates levelized cost cooling energy lcoc similar derived solar air conditioning system elsevier ltd rights reserved
multi peer assessment often used teachers reduce personal bias make assessment reliable study reviews design development multi peer assessment systems detect solve two common issues systems non consensus among group members personal radicalness assessments multi peer assessment model proposed address issues model captures roles activities data structures typical multi peer assessment setting generalized scenarios implemented model multi peer code review system conducted several empirical experiments programming language classes studies showed model significantly improve student learning outcomes single peer assessment also used statistical measures detect non consensus radicalness issues often occur model results reveal many insights provide valuable guidance teachers implement multi peer assessment system
setting despite clinical importance idiopathic pulmonary fibrosis ipf epidemiology rarely reported economic burden ipf therefore difficult predict objective analyse health care burden current situation respect medical resource utilisation patients ipf korea methods analysed nationwide data collected korean health insurance review assessment hira database patients ipf defined code korean classification disease revision results total direct health care costs increased principal factor responsible highest proportion costs hospitalisation proportion total ipf patient population hospitalised least year average length hospital stay days post hoc analysis hospital admission emergency room visit intensive care unit admission rates showed significant seasonal variations admission rates highest spring lowest autumn conclusions health care costs ipf increasing annually hospital admissions representing major financial burden
associated prime number combined model generalized bilinear kadomtsev petviashvili boussinesq equation gbkpb short terms function proposed involves four arbitrary coefficients guarantee existence lump solutions constraint among four coefficients presented firstly lump solutions constructed classified via searching positive quadratic function solutions gbkpb equation different conditions posed lump parameters investigated keep analyticity rational localization resulting solutions finally dimensional plots density plots dimensional curves particular choices involved parameters given show profile characteristics presented lump solutions potential function lnf
paper addresses problem integrating ontological knowledge bases complex software applications proposing library exposing ontology access manipulation web services proposed framework extension previous work framework enhances integrating reasoning techniques generating web services layer performing basic crud operations inferred information retrieval ontologies ontology access provided party apis jena api simple ontology access drq case using ontologies mapped relational databases storing individuals object oriented layer generated intermediate flow information data sources web services ontology reasoning rules database may generated runtime using java reflection techniques framework used diagnostic ontology perform set experiments illustrate benefits proposed solution code complexity reduction reasoning capabilities
many consumer electronics firms adopting ecosystem centric approach supporting third party applications emerging market consumer electronics firm may need create new ecosystem adopt newly developed platform significant commercial technical implications paper identify three types ecosystems used today vertically integrated hardware software platforms closed source software platforms open source software platforms introduce first step towards multi criteria decision support method determines type ecosystem suitable specific product category software engineering perspective use method analyze wide range consumer electronics products analysis shows vertically integrated platform type suitable product high degree innovation open source software platforms suitable large amount variants needed closed source software platform type less suitable types consumer electronics devices first step towards full fledged decision support method used platform owners decide whether platform also successfully transferred another product type copyright john wiley sons ltd
incorporation delay based computing polychronicity models neural networks helped increase memory representational capacity spiking neural networks however computational advantages spiking neural networks largely obviated instantiated conventional computer architecture alternative architecture advanced paradigm polychronous wavefront computation pwc pwc framework transponders embedded kind wave conductive medium used simplified representation computational processes similar exhibited spiking neural networks programming network amounts determining proper geometrical arrangement transponders within conductive medium mind therefore conjecture transforming mathematical function corresponding pwc geometry compiling representational code function could best done form swarm based optimization within physical space potential geometries herein test ability swarm algorithms particle swarm optimization select arrangements capable encoding simple mathematical functions compare convergence times one another well optimization algorithms less obvious geometrical interpretations genetic algorithms published elsevier
group innate lymphoid cells ilc exert critical roles type immune responses epithelial repair mucosal tissues metabolic homeostasis ilc rapidly provide large amounts type signature cytokines thereby driving type immune responses defense helminths however deregulated ilc facilitate tissue fibrosis trigger unwanted type immunopathologies allergies asthma atopic dermatitis therefore ilc need tightly regulated beginning understand mediators activate inhibit rare important cell population review summarize current knowledge positive negative regulation ilc discuss immunological consequences elsevier ltd rights reserved
hiv chemoprophylaxis prep pep emerged transformative prevention tool reduce infection rates decrease disease burden however uptake low efficacy depends upon adherence maximize impact potential barriers uptake adherence must identified understood using univariate logistic regression analytic methods assessed associations among potential barriers uptake adherence including hiv chemoprophylaxis knowledge negative stereotyped beliefs people use negative attitudes towards hiv chemoprophylaxis use relatives among residents two high hiv prevalence neighborhoods new york city quarter respondents knew hiv chemoprophylaxis endorsed negative stereotyped beliefs users yet approximately two thirds positive attitudes toward use among male female relative young age lesbian gay friends family members low levels homophobia associated endorsing negative stereotyped beliefs negative stereotyped beliefs associated negative attitudes toward hiv chemoprophylaxis use among relatives implications prep dissemination discussed
besides providing spatial anatomic information heart valves real time three dimensional echocardiography combined color doppler potential overcome limitations flow quantification inherent conventional color doppler methods recent studies validated application color doppler quantification regurgitation flow based vena contracta area vca proximal isovelocity surface area pisa methods particularly assessment vca led change paradigm understanding vca strongly asymmetric majority patients etiologies review provides comprehensive description different concepts based flow quantification setting different valvular heart diseases presentation recent guidelines
background thyroid hormone concentrations may deviate normal values critical illness condition known nonthyroidal illness syndrome ntis influence results screening congenital hypothyroidism neonatal extracorporeal membrane oxygenation ecmo objectives determine incidence aberrant screening results ecmo treated neonates identify possible determinants follow patients abnormal thyroid hormone concentrations methods retrospective cohort study included ecmo treated neonates admitted screened protocol divided following groups group screened ecmo group screened shortly ecmo group screened shortly ecmo results screening results aberrant neonates screened ecmo neonates screened ecmo neonates screened ecmo neonates aberrant screening result low thyroxine concentration normal thyrotropin concentration screening seen ntis none diagnosed mortality significantly differ neonates aberrant screening result neonates normal screening result screening ecmo screening ecmo higher pediatric logistic organ dysfunction score associated aberrant screening result conclusions aberrant screening results found ecmo treated neonates screened ecmo likely due ntis follow thyroid hormone concentrations best started recovery critical illness results suggest thyroxine therapy required ecmo author published karger basel
background primary purpose study assess existing evidence cost effectiveness surgical interventions management knee hip osteoarthritis systematically reviewing published economic evaluation studies methods systematic review conducted period electronic databases searched identify trial model based economic evaluation studies evaluated surgical interventions knee hip osteoarthritis results total studies met inclusion criteria assessment studies showed total knee arthroplasty tka total hip arthroplasty tha showed evidence cost effectiveness improvement quality life patients compared non operative non surgical procedures hand even though delaying tka tha may lead cost savings short run results study showed cost effective option conclusions tka tha cost effective recommended management patients end stage severe knee hip however needs additional studies assess cost effectiveness surgical interventions order definite conclusions reached
present project possible prove relationship existing internal personality variables self concept pro sociality distal variables like physical activity academic achievement within school context promoting physical activity sport also means teenagers learn personal social competence allows offer educational tool develop pro social behavior descriptive project whose sample made secondary school students socio demographic questionnaire used self concept questionnaire scale pro sociality teenagers adults cantoblanco scale socialization difficulties soc different school qualifications among results obtained confirmed physical activity ones physical self concept improves turn leads better social perception thus integrating teenager peer groups resulting better academic results
lung transplant recipient diagnosed penicilliosis due talaromyces marneffei fungus endemic south east asia acquired donor transmission first case talaromyces marneffei transmission transplantation underscores current globalisation travelling necessitates increased vigilance transmission unusual pathogens organ recipients
purpose children growing homeless families disproportionately likely experience health psychological problems objective describe social environmental individual family characteristics associated emotional behavioral difficulties among homeless children living paris region methods face face interviews representative sample homeless families conducted bilingual psychologists interviewers january may children ages years mothers reported children emotional behavioral difficulties strength difficulties questionnaire sdq family socio demographic characteristics residential mobility parents children physical mental health children interviewed regarding perception living arrangements friendships school experiences studied children sdq total score linear regression framework results homeless children higher sdq total scores children general population france mean total score multivariate analyses children difficulties associated parents region birth beta sub saharan africa beta eastern europe beta countries residential mobility beta children health beta overweight beta child sleeping habits beta mother suicide risk beta child dislike family accommodation beta child experience bullying beta conclusions children growing homeless experience high levels psychological difficulties put risk poor mental health educational outcomes long term access appropriate screening medical care vulnerable yet underserved group greatly needed elsevier masson sas rights reserved
present time dependent stop operator based prandtl ishlinskii model characterize singular hysteresis loops piezoceramic actuator model constructed based time dependent threshold inverse time dependent stop operator based prandtl ishlinskii model obtained analytically applied feedforward compensator compensate singular hysteresis loops class smart material based actuators objective study present invertible prandtl ishlinskii model applied feedforward compensator compensate singular hysteresis loops without inserting feedback control system elsevier rights reserved
globally water pollution mainly caused presence heavy metals metalloids arsenic majority techniques employed removal low efficiency high cost therefore work presented adsorption processes arsenic iii ions employing magnetite nanoparticles mnps synthesized aerosol assisted chemical vapor deposition aacvd process adsorption efficiency determined different times concentrations remaining concentration solutions analyzed atomic absorption spectroscopy adsorbed ions surface nmps analyzed high resolution transmission electron microscopy results showed overall removal efficiency contact time minutes results suggested use nmps promising alternative removal ions water
primary focus current research goal projection ascription perceiver goal onto interaction partner target extending finding perceivers project goal onto target kawada oettingen gollwitzer bargh two studies applied cognitive conceptualization goal pursuit detection explain boundary conditions goal projection conversation experiment demonstrated strength cognitive association perceivers goal social context moderated projection projection greater strongly moderately weakly linked goals experiment established target goal pursuit efficiency congruency perceiver target goals influenced projection compared targets efficient pursuit nonidentical goals projection greater target perceiver goal regardless efficiency different goals target inefficient
carotid body chemoreceptors transduce low arterial tension increased action potential activity carotid sinus nerves contributes resting ventilatory drive increased ventilatory drive response hypoxia arousal responses hypoxia sleep upper airway muscle activity blood pressure control sympathetic tone sensitivity low newborn increases days weeks birth reach adult levels postnatal functional maturation response termed resetting occurs every mammalian species studied date environment appears play key role fetus develops low environment throughout gestation initiation resetting birth modulated large increase arterial oxygen tension occurring birth although numerous studies reported age related changes various components transduction cascade environment shapes normal prenatal development postnatal resetting remains unknown viewing resetting environment driven developmental phenotypic plasticity raises important mechanistic questions received little attention review examines known known mechanisms functional maturation focus role environment elsevier rights reserved
objective paper describes field injury illness near miss evacuation profiles national outdoor leadership school nols methods nols incident database used record injuries illnesses near miss incidents close calls evacuations nonmedical incidents database used continually since results period september august program days incidents reported involving students staff athletic injuries account injuries soft tissue injuries account athletic injuries often sprains strains knees ankles backs falls slips around camp hiking leading contributing factors common illnesses gastrointestinal symptoms nausea vomiting diarrhea flu like illness including flu symptoms respiratory symptoms rock fall leading near miss incident two hundred fifty seven medical evacuees received treatment able rejoin finish course one fatality fatality rate period per program days conclusions number injuries specifically number athletic injuries declined number rate near miss incidents increased result better reporting rate nonmedical incidents held steady motivation continues leading category nonmedical incident efforts collecting incident data provide useful measurement gauge risk management performance
new approach solar electricity generation storage proposed based concept thermally regenerative batteries concentrated sunlight used external thermo chemical charging flow battery electricity produced conventional electro chemical discharge battery battery replaces steam turbine currently used commercial concentrated solar power csp plants potentially leading much higher conversion efficiency approach offers potential performance cost operational advantages compared existing solar technologies existing storage solutions management electrical grid significant contribution intermittent solar electricity generation analyze theoretical conversion efficiency new thermo electro chemical storage tecs plant schemes based electro chemical systems sodium sulfur zinc air thermodynamic upper limit solar electricity conversion efficiency ideal tecs cycle reactor temperature zinc air system sunlight concentration hybrid process carbothermic reduction zinc air system reaches theoretical efficiency practical conditions reaction temperature concentration practical tecs plant efficiency estimated upper limits may much higher compared existing solar electricity technologies technical economical feasibility proposed cycle also discussed elsevier ltd rights reserved
objective dialectical behavior therapy dbt evidence based psychosocial treatment efficacy reducing self harm behaviors borderline personality disorder bpd study describes evaluates clinical curriculum teach dbt psychiatry residents developed large urban university hospital curriculum objectives psychiatry residents achieve basic understanding dbt theory clinical skill increase residents ability confidence treating self harm behaviors suicidal behavior non suicidal self injury enhance residents willingness treat individuals bpd methods addition week didactic course dbt offered residents elected enroll year long dbt clinical training curriculum course year period dbt clinical training consisted additional didactics ongoing conduct individual therapy group dbt skills training videotaping individual therapy sessions weekly supervision meetings utilizing videotape provide feedback residents participating clinical training program videotaped baseline later sessions rated dbt adherence graduates program surveyed regarding impact training practice psychiatry results upon graduation high percentage curriculum didactic course reported incorporating dbt psychiatry practice well willingness confidence treating bpd self harm behaviors residents participating clinical training demonstrated significant improvement ability utilize dbt interventions particularly structuring sessions problem assessment problem solving using validation dialectical strategies conclusion dbt curriculum effective preparing psychiatrists training incorporate evidence based practices effective treatment bpd self harm behaviors serve model teaching dbt psychiatry residency training limitations include small sample size lack baseline survey measurement attitudes pre post curriculum comparison
prostate cancer second leading cause death cancer among males western countries also commonly diagnosed male cancer japan progression prostate cancer mainly influenced androgens androgen receptor androgen deprivation therapy established therapy advanced prostate cancer however prostate cancers frequently develop resistance low testosterone levels progress fatal stage called castration resistant prostate cancer crpc surprisingly signaling pathway still activated crpc cases overcome problem abiraterone acetate enzalutamide introduced treatment crpc despite impact drugs prolonged survival crpc acquires resistance keep pathway activated functional molecular studies shown collaborative transcription factors tfs including octamer transcription factor oct gata binding protein gata forkhead box foxa still stimulate activity castration resistant state therefore elucidating crosstalk collaborative tfs pathway critical developing new strategies treatment crpc recently many compounds targeting pathway developed treating crpc review summarize signaling pathway terms collaborators focus pyrrole imidazole polyamide candidate compound treatment prostate cancer
emergence economically viable efficient sensor technology provided impetus development smart devices appliances modern smart environments equipped multitude smart devices sensors aimed delivering intelligent services users smart environments presence diverse smart devices raised major problem managing environments rising solution problem modeling user goals intentions interacting environments using user defined goals domotic effects user goal modeling framework provides ambient intelligence ami designers integrators abstract layer enables definition generic goals smart environment declarative way used design develop intelligent applications high level nature domotic effects also allows residents program personal space see fit define different achievement criteria particular generic goal defining combination devices particular states using domain specific custom operators paper describes approach automatic enforcement domotic effects case boolean application domain suitable intelligent monitoring control domotic environments effect enforcement ability determine device configurations achieve set generic goals domotic effects paper also presents architecture implement enforcement boolean domotic effects results obtained carried experiments prove feasibility proposed approach highlight responsiveness implemented effect enforcement architecture
least mean kurtosis lmk algorithm successfully applied linear system identification outperforms conventional least mean square method gaussian non gaussian noises purpose work apply lmk algorithm active noise control anc systems develop filtered lmk fxlmk algorithm proposed fxlmk algorithm robust attenuation various noise interferences anc system improve noise reduction performance recursive sampled variance method incorporated fxlmk algorithm resulting improved fxlmk ifxlmk algorithm without significantly increasing computational burden simulations various noise inputs show effectiveness proposed algorithms moreover traction substation noise control problem considered simulations overall system scheme simulation studies conducted simulation results demonstrate ifxlmk algorithm improve convergence rate adaptive filter improve performance noise reduction
forest fire known important natural hazard many countries causes financial damages human losses thus necessary investigate different aspects phenomenon study performance four models linear quadratic discriminant analysis lda qda frequency ratio weights evidence wofe investigated model forest fire susceptibility yihuang area china purpose firstly forest fire locations map prepared implementing modis satellite images field surveys classified two groups including training validation random algorithm addition forest fire effective factors prepared used slope degree slope aspect altitude topographic wetness index twi plan curvature land use normalized difference vegetation index ndvi annual rainfall distance roads rivers wind effect annual temperature soil texture using training dataset effective factors lda qda wofe models applied forest fire susceptibility maps prepared finally area curve auc receiver operating characteristics roc implemented investigating performance models results depicted wofe best performance auc followed auc qda auc lda auc respectively results study showed high contribution altitude slope degree temperature hand seen slope aspect soil lowest importance forest fire susceptibility mapping auc results concluded wofe lda qda acceptable performance could used forest fire susceptibility mapping regional scale
afp producing adenocarcinoma variant adenocarcinoma high malignancy production afp suggests enteroblastic hepatoid differentiation cancer cells gata key molecule involved prenatal development stomach liver gata epigenetically silenced hypermethylation primer region many types cancers including gastric cancer aim study investigate expression epigenetic regulation gata alp producing adenocarcinoma immunohistochemical analysis revealed gata positive cases afp producing gastric adenocarcinomas cases common type adenocarcinomas epigenetic modification gata promoter region investigated afp producing common type gastric cancer cell lines gata mrna detected alp producing common type gastric cancer cell lines pcr methylation specific pcr revealed gata methylation afp producing gastric cancers whereas methylation consistent gata expression common type gastric cancers chromatin immunoprecipitation assay afp producing gastric cancers revealed histones hypoacetylated gata negative cells hyperacetylated gata positive cells treatment trichostain inhibitor histone deacetylase induced acetylation histones tri methylation lysine histone associated active transcription gata gata negative afp producing cells results indicated histone deacetylation silencing mechanism gata expression afp producing gastric cancer cells differences alp producing gastric cancer common type gastric cancer terms mechanism gata regulation may reflected phenotypic deviation afp producing gastric cancer common type gastric cancer elsevier inc rights reserved
study presents bioacoustic sensor system developed early detection recovery bowel activity abdominal surgery perform analysis bowel sounds different studies order able attenuate noise two capacitive microphones oriented opposite directions used bowel sounds typically observed frequency amplitude signal strength boosted times amplifying circuit second microphone used observe environmental noise examination room noise signals digitized using adc daq data acquisition usb finally developed software extract spectral properties signal present results real time
context previous studies reported caveolin cav associated lung fibrosis however role cav expression pirfenidone treated idiopathic pulmonary fibrosis ipf unknown objective study investigated cav expression pirfenidone treated ipf compared effects pirfenidone acetylcysteine prednisone ipf materials methods rat ipf model established endotracheal injection bleomycin specific pathogen free wistar male rats pirfenidone daily prednisone daily acetylcysteine times per day used treat rat model intragastric administration consecutive days respectively normal rats without ipf used controls days drug treatment lung histopathology assessed expression cav determined using real time quantitative pcr western blot expression tumour necrosis factor alpha tnf alpha transforming growth factor beta tgf beta platelet derived growth factor pdgf determined enzyme linked immunosorbent assay results days drug treatment comparison three drug treated groups model group showed significantly lower significance airsacculitis fibrosis scores lung tissues well expression tgf beta tnf alpha pdgf expression cav higher compared group fibrosis score significantly lower protein expression cav significantly higher group additionally expression cav negatively correlated airsacculitis fibrosis scores well expression tgf beta tnf alpha pdgf discussion conclusion pirfenidone prednisone acetylcysteine inhibit airsacculitis pulmonary fibrosis rat ipf models may related enhanced caveolin reduced tnf alpha tgf beta pdgf
behavior based safety bbs methods widely reported important contributor prevention accidents improvement safety performance construction projects however existing bbs methods fail look impact interactions workers supervisors overcome limitation impact supervisor behaviors safety climate workers behavioral performance examined study supervisor focused bbs method proposed accordingly takes group level safety climate mediator encourage supervisor behaviors improve workers behavioral performance construction projects case study carried construction project hong kong statistical analysis proved intervention supervisor behaviors resulted significant improvement safety climate workers behavioral safety performance sustainability bbs impacts results demonstrated focusing supervisor behaviors viable approach ameliorating effectiveness sustainability bbs improving safety performance construction industry american society civil engineers
mutations leucine rich repeat kinase lrrk gene frequent cause inherited parkinson disease common associated lrrk mutation induces increased production reactive oxygen species vitro therefore hypothesized individuals associated lrrk mutations might increased concentrations oxidative stress markers decreased total antioxidant capacity tac cerebrospinal fluid csf measured two oxidative stress markers namely hydroxy deoxyguanosine ohdg isoprostane iso tac csf lrrk mutation bearing patients lrrk sporadic patients spd healthy control subjects without mutations lrrk ctl ctl ohdg iso levels increased lrrk ctl subjects tac similar groups iso negatively correlated tac positively correlated montreal cognitive assessment scores lrrk lrrk ctl ctl subjects correlations groups patients two oxidative stress markers unified parkinson disease rating scale total scores weak tac negatively correlated scores findings suggest oxidative stress may increased cns healthy individuals associated lrrk mutations tac may decrease cns progression cognitive impairment present regardless presence absence
present cooperative aerial robot system transportation hoses hose robot attachment makes whole system physically interconnected rigid control design becomes difficult nonlinear optimization problem hose quasistationary state modeled sections catenary curves use proportional integral derivative pid controllers quadrotor attitude trajectory control tuned particle swarm optimization pso work test pso minimizing energy function achieve pid controller tuning horizontal motion quadrotor teams transporting hoses different stress conditions
benign intraperitoneal metastatic leiomyomatosis rare benign disease observed leiomyoma present peritoneal surface women undergone hysterectomy leiomyomas commonly affected patients usually asymptomatic presentation frequently incidental finding imaging studies ultrasound play important role diagnosis lesions histologically identical uterine counterparts different theories pathogenesis disease including peritoneal seeding laparoscopic hysterectomy others support hypothesis multiple independent foci smooth muscle proliferation treatment uterine leiomyomatosis generally conservative report year old hysterectomized woman intraperitoneal leiomyomas detected routine physical examination mobile abdominal masses underwent successful laparoscopic resection
background types abuse neglect associated suicide attempts however association level type childhood trauma suicidal behavior severity including progression ideation attempts adjusting occurrence yet clear methods used cross sectional web based survey collected brazilian internet study temperament psychopathology brainstep investigate isolated effects type childhood trauma suicidal behavior severity sample consisted self selected volunteers assessed childhood trauma questionnaire ctq following key question ever thought attempted kill suicidal behavior questionnaire sbq results adjusting demographic variables childhood trauma subtypes severe emotional abuse associated suicidal ideation attempts mainly serious suicide attempts found associations smaller magnitude severe emotional neglect serious suicide attempts severe physical neglect sexual abuse attempts without really meaning die meaningful trend physical abuse found using reference group ideators associated serious suicide attempts peak percentile found associations smaller magnitude meaningful trend conclusions suicidal behavior strongly associated emotional abuse childhood even compared ideators suggesting relevant factor progression ideation attempts elsevier masson sas rights reserved
objective purpose evaluate effectiveness progressive muscle strengthening program using swiss ball patients methods sixty patients randomized intervention group control group eight exercises performed patients free weights swiss ball two times per week weeks evaluations performed blinded evaluator baseline weeks using following instruments one repetition maximum test basmi basfi haq minute walk test time test basdai asdas esr crp dosage likert scale results statistical difference groups strength capacity following exercises abdominal rowing squat triceps reverse fly minute walk test timed test likert scale better results differences observed groups respect functional capacity evaluation using basfi haq basmi tug asdas esr cpr dosage conclusions progressive muscle strengthening using swiss ball effective improving muscle strength walking performance patients elsevier editora ltda
investigation paper integro differential nonlinear schrobinger idnls equation equivalent spin evolution equation classical homogeneous heisenberg magnetic chain continuum limit based hirota method bilinear form soliton solution idnls equation derived help symbolic computation moreover soliton solution idnls equation expressed terms double wronskian testified direct substitution bilinear form besides bilinear backlund transformation infinitely many conservation laws also obtained idnls equation propagation characteristics interaction behaviors solitons discussed analysis physical quantities soliton amplitude width velocity initial phase interactions solitons proved elastic asymptotic analysis effect inhomogeneity interaction solitons studied graphically
rapid integration technology professional personal lives left many education systems ill equipped deal influx people seeking computing education improve computing education applying techniques developed procedural fields present study applied technique subgoal labeled worked examples explore whether would improve programming instruction first two experiments conducted laboratory suggest intervention improves undergraduate learners problem solving performance affects learners approach problem solving third experiment demonstrates intervention similar perhaps stronger effects online learning environment service teachers want become qualified teach computing courses implementing subgoal intervention tool educators teach students education systems could improve computing education better prepare learners increasingly technical world
cortana one new features introduced microsoft windows desktop operating systems voice activated personal digital assistant used searching stuff device web setting reminders tracking users upcoming flights getting news tailored users interests sending text emails platform relatively new forensic examination cortana largely unexplored literature paper seeks determine data remnants cortana usage windows personal computer research contributes depth understanding location evidentiary artifacts hard disk type information recorded artifacts result user activities cortana decoding exporting data one databases created cortana application four custom python scripts developed additionally part paper gui tool called cortanadigger developed extracting listing web search strings well timestamp search made user cortana box several experiments conducted track reminders based time place person detect anti forensic attempts like evidence modification evidence destruction carried cortana artifacts finally forensic usefulness cortana artifacts demonstrated terms cortana web search timeline constructed period time elsevier ltd rights reserved
background contingency management demonstrated efficacy treating many drug addictions including nicotine however one commonly perceived limitations regard dissemination community settings whether protocol could equally effective treating patients across different income levels objective study aimed examine whether individuals income levels affect treatment success cognitive behavioral treatment cbt included voucher based protocol smoking cessation methods total treatment seeking smokers community setting randomly assigned cbt group cbt plus group procedure included voucher program smoking abstinence reinforced schedule escalating magnitude reinforcement reset contingency analyzed impact self reported monthly income alone combination treatment condition short term treatment retention long term self reported number days continuous smoking abstinence month follow results results income effect treatment retention continuous abstinence outcomes month follow either treatment condition treatment modality emerged significant predictor treatment success conclusions findings suggest treatment seeking smokers general population respond equally well regardless income levels results randomized controlled trial support generalizability evidenced based program community settings
fundamental concern human beings mortality salience impacts various human social behaviors including intergroup interactions however underlying neural signature remains obscure examined neural signatures underlying impact mortality reminders group bias costly punishment combining second party punishment task multivariate pattern analysis fmri data mortality salience priming general negative affect priming participants received offers racial group group proposers decided punish proposers reducing payoffs revealed priming attenuated group bias dampened discriminated activation patterns pertaining group identities regions previously implicated costly punishment including dorsomedial prefrontal cortex temporo parietal junction anterior cingulate cortex dorsolateral prefrontal cortex group identity represented multivariate patterns activity regions predicted group bias control condition stronger discriminative representations group identities regions larger group bias furthermore group bias reliably decoded distributed activation patterns punishment related networks control condition condition findings elucidate neural underpinnings effects mortality reminders intergroup interaction hum brain mapp wiley periodicals inc
background stereoisomer inositol scyllo inositol regarded promising therapeutic agent alzheimer disease however compound relatively rare whereas another stereoisomer inositol myo inositol abundant nature bacillus subtilis ability metabolize inositol stereoisomers including previously reported subtilis cell factory modified inositol metabolism converts culture medium strain constructed deleting genes related inositol metabolism overexpressing key enzymes iolg iolw using strain initially included medium completely converted within cultivation rich medium containing bacto soytone results initial concentration increased conversion limited therefore overexpression systems iolt pntab main transporter subtilis membrane integral nicotinamide nucleotide transhydrogenase escherichia coli respectively additionally introduced subtilis cell factory conversion efficiency hardly improved systematically determined amount bacto soytone necessary ultimate conversion result conversion reached within cultivation conclusions subtilis cell factory improved yield production rate simultaneous overexpression iolt pntab addition bacto soytone conversion medium concentration increased even stationary phase perhaps due nutrients bacto soytone contribute conversion process thus conversion may optimized via identification control unknown nutrients
internet addiction become public health issue neglected jordan need investigate issue among school students descriptive correlational study aimed assess prevalence internet addition associated risk factors jordanian school students participants aged years selected randomly ten public schools amman governorate jordan socio demographical data patterns internet usage young internet addiction tool yiat symptom checklist anxiety scale scl anxiety center epidemiological studies depression scale children ces used findings showed prevalence severe internet addiction highest prevalence internet addiction among students family monthly income fathers completed elementary education mothers completed university higher education academic performance poor friend home favorite place among internet addicted students chatting highest reason internet addiction students experiencing anxiety depression symptoms highest prevalence internet addiction respectively statistically significant relationship age school grade family income academic performance average hours internet daily usage school days holidays anxiety depression internet addiction findings emphasize importance developing implementing interventions preventive measures early diagnosis internet addiction among school students furthermore counseling programs recommended increase awareness families regarding internet addiction responsibilities providing guidance support children elsevier ltd rights reserved
background smoking aberrant epithelial responses risk factors lung cancer well chronic obstructive pulmonary disease idiopathic pulmonary fibrosis conditions disease progression associated epithelial damage fragility airway remodelling sub epithelial fibrosis aim study assess acute effects cigarette smoke epithelial cell phenotype pro fibrotic responses vitro vivo results apoptosis significantly greater unstimulated cells copd patients compared control proliferation cxcl release different cigarette smoke dose dependently induced apoptosis proliferation cxcl release normal epithelial cells responsive copd patient derived cells cigarette smoke induce epithelial mesenchymal transition vivo cigarette smoke exposure promoted epithelial apoptosis proliferation moreover mimicking virus induced exacerbation exposing mice poly exaggerated inflammatory responses whereas expression remodelling genes similar conclusions collectively data indicate cigarette smoke promotes epithelial cell activation hyperplasia secondary stimulus required remodelling phenotype associated copd
among interstitial lung diseases ilds idiopathic pulmonary fibrosis ipf chronic hypersensitivity pneumonitis fibrotic connective tissue disease related ild associated worse prognosis death occurring result respiratory failure serious associated comorbidities recent development approval antifibrotic agents nintedanib pirfenidone reduced rate decline lung function patients ipf clinical trials offer hope may possible alter increased mortality associated ipf although chronic hypersensitivity pneumonitis connective tissue disease related ild may associated inflammatory component evidence use immunosuppressive agents treatment largely limited retrospective studies lack benefit immunosuppressive therapy advanced fibrosis argues rigorous clinical trials using antifibrotic therapies types ild well patients fibrotic ild may benefit identification management associated comorbid conditions pulmonary hypertension gastroesophageal reflux osa may improve quality life cases survival affected individuals early assessment may optimize posttransplantation outcomes lung transplant evaluation occur early patients ipf forms fibrotic ild
article utilizes trope domesticity domestication order explore notions gendered temporality hou hsiao hsien cafe lumiere dialogue chinese writer eileen chang western theories women time domestic temporality article proposes works hou chang described instances ecriture feminine interrogate ambivalence toward domesticity drawing chantal akerman film contrast hou article demonstrates use cinematographic long take domesticates time space well ways horror everyday domesticity captured rey chow calls feminine details finally present article argues cafe lumiere domesticates fear domesticity pregnancy reconfiguration linear cyclical time reversal gender roles protagonists privileging aurality visuality cinematic style presents potential new kind union new kind futurity premised upon reordered gendered forms temporality
background study assessed efficacy safety methotrexate mtx compared thiopurines tps refractory crohn disease methods fifty one consecutive patients refractory intolerant tps steroid dependent retrospectively analyzed mtx subcutaneous adopted inducing maintaining clinical remission fifty seven patients naive immunosuppressant prescribed azathioprine mercaptopurine simultaneously recruited results week rate mtx tps groups respectively patients disease duration years likely achieve mtx odds ratio week rate patients achieved remission week mtx tps groups respectively normalization high sensitivity reactive protein level relative risk platelet count relative risk week predicted efficacy maintaining remission mtx among patients remission week mucosal healing rates week mtx tps fifteen patients mtx tps experienced adverse events conclusions mtx effective inducing maintaining achieving mucosal healing patients refractory crohn disease efficacy comparable tps naive patients side effects mtx mild tolerable
previous studies demonstrated matrix factorization techniques nonnegative matrix factorization nmf concept factorization yielded impressive results image processing data representation however conventional variants single layer factorization fail capture intrinsic structure data paper propose novel sequential factorization method namely graph regularized multilayer concept factorization gmcf clustering gmcf multi stage procedure decomposes observation matrix iteratively number layers addition gmcf incorporates graph laplacian regularization layer efficiently preserve manifold structure data efficient iterative updating scheme developed optimizing gmcf convergence algorithm strictly proved computational complexity detailedly analyzed extensive experiments demonstrate gmcf owns superiorities terms data representation clustering performance elsevier rights reserved
considerable evidence association obesity impaired executive function adolescents adults however little research examined overweight obese children furthermore data underweight individuals lacking addition consensus directionality relationship body mass index bmi longitudinal studies rare thus present study examined whether children differ performance battery tasks depending weight status underweight normal weight overweight investigated longitudinal cross lagged associations bmi hot delay gratification affective decision making cool attention shifting inhibition working memory updating bmi assessed german elementary school children two time points approximately oneyear apart overweight children exhibited slightly poorer attention shifting updating affective decision making abilities compared normal weight children unexpectedly show deficits inhibition delay gratification levels underweight children differ significantly normal weight children furthermore poor attention shifting enhanced affective decision making predicted slightly higher bmi oneyear later higher bmi also predicted poorer attention shifting updating oneyear later latter association bmi subsequent scores however diminished controlling socioeconomic status results indicate hot cool plays role weight development children might promising factor address preventive interventions
discovery jak mutation mid started fill gap clinical presentation polycythemia vera first described vaquez end century spontaneous erythroid colony formation reported prchal axelrad mid knowledge mutation brought important insight understanding pathogenesis led revision world health organization diagnostic criteria jak stat major signaling pathway implicated survival proliferation hematopoietic precursors high prevalence jak mutation among myeloproliferative neoplasms similar primary myelofibrosis essential thrombocythemia together role constitutively activating jak stat made jak privileged therapeutic target ruxolitinib jak inhibitor already proven efficient relieving symptoms primary myelofibrosis latter also appears improve microvascular involvement however evidence regarding potential role altering natural course use adjunct current standard therapies sparse therapeutic advances needed phlebotomy low dose aspirin cytoreductive agents interferon alpha therapeutic tools available moment influence outcome even though several questions still unanswered review aims serve overview article potential role ruxolitinib according current literature expert opinion help hematologists visualize place tyrosine kinase inhibitor field current practice offer criteria careful patient selection
curbing water scarcity problems semi arid regions top priority economic social development alternative strategies sustainable domestic water supply therefore required augment water supply affordable cost technology scant research findings sub saharan africa however reported inefficiency adapting water scarcity problems region therefore investigation domestic rainwater harvesting rwh reliability important identify factors affecting system found rainwater harvesting existing traditional rwh systems mekelle city unreliable unreliability attributed inefficient design systems installed without considering deterministically stochastic nature rainfall family size water demand rooftop area storage tank size
overeating physical inactivity great importance etiology obesity psychological factors often found background life style chronic stress contribute physical inactivity behaviors hinder keeping diet irregular eating pattern emotional eating results randomized controlled trials show relaxation reduce emotional eating improve cognitive restraint thereby reduce weight however stress management relaxation consists adaptive emotion focused problem focused coping strategies skills improve relationships deflection skills may help replacing emotional eating behaviors cognitive restructuring saying problem solving help prevent manage conflicts difficulties otherwise would result overeating due distress developing stress management skills may result greater compliance treatment techniques presented study easily applied general practitioners specialists provide tools optimizing obesity treatment
background ultrasound used treatment wide variety musculoskeletal disorders include acute ankle sprains update cochrane review first published previously updated objectives evaluate effects ultrasound therapy treatment acute ankle sprains search strategy searched cochrane bone joint muscle trauma group specialised register september cochrane central register controlled trials cochrane library issue medline september embase september cinahl pedro physiotherapy evidence database accessed also searched cochrane rehabilitation related therapies field database reference lists articles contacted colleagues international clinical trials registry platform searched ongoing trials selection criteria randomised quasi randomised trials included following conditions met least one study group treated therapeutic ultrasound participants acute lateral ankle sprains outcome measures included general improvement pain swelling functional disability range motion data collection analysis two authors independently performed study selection assessed risk bias extracted data risk ratios risk differences together confidence intervals calculated dichotomous outcomes mean differences together confidence intervals continuous outcome measures limited pooling data undertaken clinical homogeneity terms participants treatments outcomes follow time points main results six trials included involving participants five trials included comparisons ultrasound therapy sham ultrasound three trials included single comparisons ultrasound three treatments assessment risk bias hampered poor reporting trial methods results none five placebo controlled trials sham ultrasound demonstrated statistically significant differences true sham ultrasound therapy outcome measure one four weeks follow pooled risk ratio general improvement one week random effects model confidence interval active versus sham ultrasound differences intervention groups generally small zero six per cent dichotomous outcomes authors conclusions evidence five small placebo controlled trials included review support use ultrasound treatment acute ankle sprains potential treatment effects ultrasound appear generally small probably limited clinical importance especially context usually short term recovery period injuries however available evidence insufficient rule possibility optimal dosage schedule ultrasound therapy may benefit
many studies related sno sno based solar thermochemical water splitting cycle however still studies addressing detailed thermodynamic analysis process using hsc chemistry software thermodynamic database cycle first step belongs endothermic solar thermal reduction sno producing gaseous sno second step corresponds exothermic production via water splitting reaction using sno produced first cycle thereby regenerating sno recycled back step thermodynamic equilibrium compositions associated step identified function reaction temperatures partial pressures inert carrier gas furthermore thermodynamic efficiency analysis performed following second law thermodynamics determine cycle solar fuel energy conversion efficiencies associated sno sno based thermochemical water splitting cycle effects thermal reduction water splitting temperatures various thermodynamic parameters also investigated detail obtained results indicate higher values cycle efficiency solar fuel energy conversion efficiency achievable operating cycle thermal reduction temperature water splitting temperature equal heat recuperation work gives detailed thermodynamic efficiency analysis sno sno based two step solar thermochemical water splitting cycle hydrogen production elsevier ltd rights reserved
medically assisted procreation significantly contributes increase twin pregnancies one major factors contributing twin births use fertility treatments twin pregnancy without risk fetal organ development health outcome new borns children adults multiple pregnancies associated increased risk developmental complications perinatal mortality premature births low birth weight oxidative stress involved pregnancy disorders abortion intrauterine growth retardation prenatal mortality link oxidative stress prenatal development poorly perceived medical community major problem human reproductive medicine health outcomes sex based considerations analyses also often neglected biomedical research addition fetal sexual dimorphism antioxidant pathways following intrauterine exposure environmental pollutants explored important area research sexually dimorphic antioxidant adaptive responses early life exposure induced oxidative stress may long term effects offspring health outcome increase risk non communicable diseases men women concept useful since may open avenue develop antenatal antioxidant therapeutic strategies developmental disorders complications related multiple pregnancies association acute chronic environmental exposure article reviews status research supporting data possible pathogenic mechanisms future perspectives proposed area birth defects research part wiley periodicals inc
study deals design load sensorless multi loop control system stand alone inverter proposed strategy inverter current measured practically required control protection purposes load voltage current estimated using linear kalman filter algorithm gradient descent adaptive control method respectively estimated quantities used feedback signals inner outer double loop controller uses proportional resonant outer controller regulate output voltage minimum steady state error simple proportional inner controller provide active damping improve transient performance controller parameters designed frequency domain based required bandwidth stability margin furthermore controllability observability well stability overall digital control system including dynamics estimators analytically investigated simulation experimental results prototype confirm theoretical achievements illustrate excellent performance proposed estimation control scheme
objective complete traumatic avulsion ischial tuberosity young athletes rare optimal treatment unclear purpose article present experience efficacy surgical repair avulsions ischial tuberosity bony dislocation discuss complex postoperative rehabilitation methods three young athletes sustained complete avulsion ischial tuberosity bony dislocation different sport activities long jump soccer sprinting age time injury ranged years underwent surgical repair reattachment hamstring muscle complex origin ischium time injury repair varied weeks patients underwent specific postoperative rehabilitation program follow ranged months results athletes improved surgery good subjective objective functional results one patient needed operative revision day primary repair suture loosening excessive muscle contractions wake general anesthesia finally returned preinjury sport level conclusions young athletes traumatic avulsion ischial tuberosity dislocation benefit operative repair good results achieved cases basis functional recovery patient satisfaction chronic complaints could avoided also return sport possible surgery spinal anesthesia recommended
transactional model stress coping responses key preventing stress response study possible role psychological well personal determinant coping strategies academic context analyzed specifically study two objectives identify different profiles students according level psychological well analyze differences profiles use three coping strategies positive reappraisal support seeking planning age gender degree estimated covariables total university students participated study latent profile analysis applied four indices psychological well self acceptance environmental mastery purpose life personal growth optimal four profile solution reflecting significant incremental shifts low high psychological well obtained predicted profile membership distinguished participants positive reappraisal support seeking planning importantly higher profile psychological well higher use three coping strategies gender differences coping strategies observed interaction effects psychological well found age degree relevant explaining use coping strategies results suggest psychological well stands important personal resource favor adaptive coping strategies academic stress
purpose study aims validate score predicting risk complications pediatric patients chemotherapy related febrile neutropenia evaluate performance previously published models risk stratification patients methods children diagnosed cancer presenting evaluated prospective single center study score predicting risk complications previously derived unit validated prospective cohort performance six predictive models published geographically distinct settings assessed cohort results complications observed episodes months risk score based undernutrition two points time last chemotherapy five points absolute neutrophil count per two points used stratify patients low risk score assessed using following parameters overall performance nagelkerke calibration calibration slope hosmer lemeshow test discrimination statistic overall sensitivity negative predictive value clinical net benefit six previously published rules demonstrated inferior performance cohort conclusion indigenous decision rule using five simple predefined variables successful identifying children risk complications prediction models derived developed nations may appropriate low middle income settings need validated use
criminal justice research frequently investigates relationships punishment decisions demographic characteristics accused gender race age many similarities criminal justice child welfare cases research child maltreatment yet examine potential demographic influences case outcomes current study examines relationships parent gender type maltreatment child removal among agency responses child maltreatment cases using data collected national data archive child abuse neglect data system ncands identify differences likelihood child removal parental home across type maltreatment perpetrator gender results indicate mother perpetrators physical abuse face significantly higher likelihood removal mother perpetrators neglect risk losing children father perpetrators physical abuse neglect findings suggest gendered attributions stereotypes regarding parenting shape assessments parents blameworthiness dangerousness rehabilitative potential propose future research child maltreatment cases adapt apply justice concepts frameworks uncover potential unwarranted demographic disparities agency decision making elsevier ltd rights reserved
development home area network residents opportunity schedule power usage home aiming reducing electricity expenses moreover renewable energy sources deployed home energy management system needs consider energy consumption generation simultaneously minimize energy cost paper smart home energy management model presented considers energy consumption generation simultaneously proposed model arranges household electrical thermal appliances operation monetary expense customer minimized based time varying pricing model model home gateway receives electricity price information well resident desired options order efficiently schedule appliances shave peak well scheduling approach tested typical home including variety home appliances small wind turbine panel battery period elsevier ltd rights reserved
normal physiological functions require robust biological timer called circadian clock clocks dysregulated misaligned dampened pathological consequences ensue leading chronic diseases accelerated aging emerging research area development clock targeting compounds may serve drug candidates correct dysregulated rhythms hence mitigate disease symptoms age related decline review first present concise view circadian oscillator physiological networks regulatory mechanisms circadian amplitude given close association circadian amplitude dampening disease progression clock enhancing small molecules cems particular interest candidate chronotherapeutics recent proof principle study illustrated natural polymethoxylated flavonoid nobiletin directly targets circadian oscillator elicits robust metabolic improvements mice describe mood disorders aging potential therapeutic targets cems future studies cems shed important insight regulation disease relevance circadian clocks
paper describes method used schaeffler analyze integrated hybrid transmission architectures one electric motor properties modes aspects mode transitions become clear using special visualization techniques method implemented matlab several transmission examples discussed leads design aspects requirements concerning overall transmission layout components examples beneficial components schaeffler discussed small shifting elements allow space electric motor clutches brakes cvt subsystems right size hybrid transmissions provide required comfort low friction bearings demand actuators contribute increased range electric driving
although democracies ideally elect leaders based abilities voters often biased seemingly unrelated factors candidate appearance prior work examining relations election outcomes appearance primarily focused restricted range top candidates examined pairwise comparisons present study tested whether predictive ability ratings based facial appearance would extend wider range candidates specifically examined whether individuals could predict outcomes bulgarian presidential elections evaluating facial appearance candidates large number candidates naturally running high level office allowed accurately test strength relationship judgments facial appearance election outcomes across broad range faces found strong correlation ratings facial competence election outcomes persisted across full range candidates participants hypothetical choices paralleled actual bulgarian election outcomes demonstrated competence ratings effective predicting election outcomes judgments variety characteristics deemed important bulgarian voters well ratings attractiveness furthermore judgments competence largely drove correlation hypothetical actual votes elsevier inc rights reserved
article presents recent efforts improving efficiency scalability mixed cell computation step context polyhedral homotopy method solving systems polynomial equations important problem applied mathematics polyhedral homotopy method important numerical method task method necessary preprocessing step known mixed cell computation problem main bottleneck parallel efficiency scalability article presents recent remarkable improvements parallel scalability algorithm applicable wide range hardware architectures including multi core systems numa systems computer clusters gpus devices elsevier ltd rights reserved
subspace based model predictive control smpc combination result subspace system identification model predictive control mpc method particularly uses subspace linear predictor equation predict future value system mpc implementation instead usual state space representation recursive subspace identification updates estimation extended observability matrix online presented multi input ulti output mimo system specifically nonlinear biological waste water treatment process givens rotation applied recursive updating decomposition matrix smpc smpc need explicit state space representation system abolished resulting control algorithm performs system identification controller design single simultaneous step additionally smpc algorithm inherit numerical robustness typical subspace based methods thus giving easily deployable control implementation adaptive framework
objective present focused review scientific literature effect alcohol consumption violence related injuries assessed emergency room show psychological behavioral sciences could lead better understanding factors contributing alcohol related injuries retrieved published literature detailed search academic search premier medline full text psycarticles psychology behavioral sciences collection psycinfo pubmed socindex full text articles related emergency rooms medical problems sociocognitive models addressing alcohol intoxication articles first search conducted june updated august literature shows compared uninjured patients injured ones higher probability elevated blood alcohol concentration upon arrival reporting drunk alcohol six hours preceding event iii suffering drinking related consequences adversely affect social life main neurocognitive sociocognitive models alcohol aggression also discussed order understand aetiology violence related injuries emergency rooms suggestions made future research prevention
objective adjunctive antipsychotic therapy prescribed patients depression inadequate response antidepressants study aimed describe use adjunctive antipsychotics time period includes authorization prolonged release quetiapine first adjunct antipsychotic used major depressive disorder research design methods adults episode depression january july identified antidepressant prescriptions depression diagnoses clinical practice research datalink patients prior records bipolar disorder schizophrenia antipsychotic prescriptions excluded main outcome measures rates adjunct antipsychotic initiation characteristics management patients adjunct antipsychotics results adults depression initiated adjunct antipsychotic therapy overall incidence antipsychotic initiation per patient years overall rate change although initiation typical antipsychotic prescribing decreased atypical antipsychotics especially quetiapine increased initiated antipsychotics women typical antipsychotics atypical antipsychotics median age years typicals years atypicals years conclusions antipsychotics rarely used treat depression primary care choice adjunctive antipsychotic therapy changed time atypical antipsychotics representing preferred treatment choice however information patients strictly cared settings psychiatrists hospitals potentially severe patients unavailable may differ nonetheless high label use primary care even authorization quetiapine suggests need licensed treatment options adjunctive antipsychotic therapy major depressive disorder
wells turbine blade bidirectional curved surface design frequently applied hydropower wind power generations study proposes new design method improve traditional straight shaped blade based key design points determining curvature blade profile increase turbine efficiency measure rotating speed electrical generator new turbine driven study develops simple wind generating tube power evaluation experimental turbine prototypes manufactured cnc engraving device optimal parametric design derived taguchi experiments finally confirmation experiments performed verify outcomes improved design results showed proposed method enhance turbine efficiency approximate
three experiments reported explore affectively based spontaneous evaluative impressions seis stimulus persons experiments used modified versions savings relearning paradigm carlston skowronski confirm occurrence seis indicating equivalent whether participants instructed form trait impressions evaluative impressions neither experiments also show seis occur independently explicit recall trait implications stimuli experiment provides single dissociation test distinguish seis spontaneous trait inferences stis showing disrupting cognitive processing interferes trait based prediction task presumably reflects stis affectively based social approach task presumably reflects seis implications findings potential independence spontaneous trait evaluative inferences well limitations important steps future study discussed
compare mri defined back muscle volume patients age spinopelvic alignment matched control patients chronic back pain male patients enrolled age spinopelvic alignment matched controls male found among non patients chronic back pain matching procedure fully matched controls found patients represent patients without deformity however matched controls found patients represent patients deformity mri parameters back muscle paraspinal muscle psoas muscle disc level including cross sectional area csa fat free cross sectional area fcsa compared patients matched controls covariates including bmi self reported physical activity presence chronic disease influence back muscle volume also investigated statistical differences age body mass index score back pain nrs spinopelvic alignment physical activity matched patients control patients except duration back pain mri parameters paraspinal muscle volume matched patients without deformity significantly less control patients significantly larger non matched patients deformity body size adjusted mri parameters relative csa relative fcsa paraspinal muscle showed strong correlations lumbar lordosis sacral slope relationship paraspinal muscle spinopelvic parameters remained significant even multivariate adjustment patients without deformity already decreased paraspinal muscle volume compared age spinopelvic alignment matched non patients chronic back pain decrease paraspinal muscle volume significantly associated kyphotic deformity patients even multivariate adjustment although result study supports causal relationship muscle degeneration kyphotic deformity patients study required prove causality
material system circulating fluidized bed boiler could divided two gas solid two phase flow circulates inside outside actually traditional modeling ways always focus analyze gas solid two phase flow microscopic point view paper collision friction gas solid particle neglected macro point view fluid network model built signal flow graph theory algorithm description nodes branches built finally according graph modeling software form based signal flow graph built
paper presents semi adaptive control approach closed loop medication infusion problems rationale underlying approach design controller adapt model parameters large impact model fidelity fixing remaining parameters nominal values paper control oriented model purpose derived via system identification sensitivity analysis low order model capturing direct dose response relationship using model thus derived model reference adaptive controller composite adaptive controller designed compared silico simulation results using remifentanil effect respiratory rate example indicate controllers regulate output commanded set points copyright john wiley sons ltd
sustainable water management may strongly benefit integrated approach additionally integrated urban water management policy considering various urban water flows possible interactions water sector remaining urban activities benefit based urban metabolism based analysis article assesses water flows lisbon metropolitan area considering conventional water supply system wastewater treatment system flows also hydrological cycle flows proposes global set indicators perform benchmarking analysis municipalities region results highlighted heterogeneous nature metropolitan area terms water management either terms management entities predominantly public municipalized water consumption varying hab day palmela hab day seixal wastewater treatment municipalities already undergo secondary tertiary wastewater treatments runoff indices depending municipality level urbanization among output volumes also assessed potential municipalities reuse wastewater potable non potable urban uses well potential harvest harness rainwater main constraints integrated water management identified potential solutions measured proposed even though need assessment particularly cost benefit perspective elsevier rights reserved
reconstruction point spread function psf critical process weak lensing measurement develop real data based galaxy oriented pipeline compare performances various psf reconstruction schemes making use large amount cfhtlens data performances three classes interpolating schemes polynomial kriging shepard evaluated find polynomial interpolations optimal orders domains perform best quantify effect residual psf reconstruction error shear recovery terms multiplicative additive biases spatial correlations using shear measurement method zhang find impact psf reconstruction uncertainty shear shear correlation significantly reduced cross correlating shear estimators different exposures takes stars greater similar per square arcmin exposure reach best performance psf interpolation requirement satisfied cfhtlens data
objective hiv prevalence data collected routine hiv testing pregnant women antenatal clinics anc potentially available facilities offer testing services pregnant women used improve estimates national subnational hiv prevalence trends develop methods incorporate new data source joint united nations programme aids estimation projection package spectrum methods develop new statistical model incorporating anc hiv prevalence data aggregated either health facility level site level regionally census level estimate hiv prevalence alongside existing sources hiv prevalence data anc unlinked anonymous testing anc uat household based national population surveys synthetic data generated understand availability anc data affects accuracy various parameter estimates results estimate hiv prevalence additional parameters using anc existing data fitting hiv prevalence using synthetic data generally gives precise estimates underlying trend parameters years anc data improve prevalence estimates anc sites continuation existing anc uat sites may improve estimate calibration anc uat anc sites conclusion proposed methods incorporate anc data spectrum obtain precise estimates prevalence measures epidemic many assumptions accuracy consistency representativeness anc prevalence underlie use data monitoring hiv epidemic trends tested data become available national anc programs
order reduce accumulation hydrogen thus mitigate risk combustion many countries installed passive autocatalytic recombiners pars within light water reactor containments severe hydrogen combustion events recent fukushima daiichi accident likely incentivize increased demand upgrading nuclear power plants pars numerical simulation important tool assessing par operation severe accident terms efficiency proper installation advanced numerical par models required challenging boundary conditions severe accident example low oxygen amount high steam amount presence carbon monoxide reko direkt code developed order provide par model capable simulating complex par phenomena time suitable implementation thermal hydraulic codes development reko direkt supported small scale experiments performed forschungszentrum juelich reko facilities facilities allow study par related single phenomena reaction kinetics different conditions including variation steam oxygen carbon monoxide reko chimney effect reko recently code validated full scale experiments performed thermal hydraulics hydrogen aerosols iodine thai facility eschborn germany framework organisation economic operation development nuclear energy agency thai project code proven applicability different par designs broad range boundary conditions pressure bars steam amount vol low oxygen conditions reko direkt successfully implemented commercial computational fluid dynamics code ansys cfx well code cocosys gesellschaft anlag und reaktorsicherheit grs germany
ever increasing load insufficient growth generation transmission capacities operating constraints modern integrated power system increasing led ever increasing dynamic problems low frequency oscillations system needs detected damped quickly efficiently electrical power networks small oscillations appear time time oscillations concern quantities determining equilibrium point system following system stability system behaviors influenced objective study check static stability high voltage power small perturbations electrical network context linearizing system power system stabilizer pss far extensively utilized mitigate problems paper presents novel efficient approach optimal tuning power system stabilizer parameters pss using genetic algorithm eigenvalue based objective function proposed approach implemented examined system single machine connected infinite bus via transmission line results technique verified eigenvalue analysis time domain simulations obtained results evaluated compared ones obtained ordinary gas eigenvalue analysis nonlinear system simulations demonstrated effectiveness proposed approach damping electromechanical oscillations enhancing system dynamic stability
current study aimed test developmental model dissociation model based clinical observations research findings concerning role childhood emotional neglect development maintenance dissociative symptoms seven hundred ninety two adult volunteers completed questionnaires parental bonding theory mind alexithymia dissociation significant associations found investigated variables multiple mediation analysis showed relationship childhood emotional neglect dissociation totally mediated theory mind alexithymia findings study support view childhood experiences emotional neglect may foster difficulties mentalizing well problems affect regulation two factors interacting generate excessively activated dissociative processes may suggest individuals exposed emotional neglect childhood currently suffer dissociative symptoms may greatly benefit clinical interventions aimed foster mentalized affectivity
optimum economic sizing water distribution network focus study many researches projectors represent relevant part sanitation programs known works approaches implantation cost considering pipes biggest heavy project problem reduced sizing pipes objective reach cheaper network satisfying minimum hydraulic prerequisites leads choice network pipes minor diameters since choice satisfies hydraulics restrictions new brazil approach consider maintenance cost throughout life span network one way larger diameters expensive resistant break rugosity effects leads network minimum maintenance cost throughout life span reach equilibrium implantation cost maintenance cost
help symbolic computation system maple riccati equation expansion method linear variable separation approach new family exact solutions gamma dimensional generalized calogero bogoyavlenskii schiff system gcbs derived based derived solitary wave solution novel localized excitations fusion fission annihilation complex waves investigated
meet person article presents synthesis two interviews andre delbecq senior fellow ignatian center jesuit education professor management leavey school business santa clara university andre pioneering researcher number areas management scholarship group decision making nominal group technique managing innovation change career extending years experienced shift late career toward study executive leaders spirituality interviews andre talked shift providing inspiring example successful career transition well personal insight venturing new areas research andre career example engaged scholarship academic researcher development decentered academic product
report theoretical experimental realization spr based fiber optic nicotine sensor coatings silver graphene doped zno nanostructure onto unclad core optical fiber volume fraction graphene zno optimized using simulation electric field intensity four types graphene doped zno nanostructures viz nanocomposites nanoflowers nanotubes nanofibers prepared using optimized value morphology photoluminescence spectra vis spectra nanostructures studied peak intensity found highest zno graphene nanofibers optimized value zno graphene nanofiber reconfirmed using vis spectroscopy experiments performed fiber optic probe fabricated zno graphene layer optimized parameters situ detection nicotine interaction nicotine zno graphene nanostructures alters dielectric function zno graphene nanostructure manifested terms shift resonance wavelength sensing signal performance parameters measured including sensitivity limit detection lod limit quantification loq stability repeatability selectivity real sample prepared using cigarette tobacco leaves analyzed using fabricated sensor makes suitable practical applications achieved values lod loq found unrivalled comparison reported ones sensor possesses additional advantages immunity electromagnetic interference low cost capability online monitoring remote sensing
introduction hydroxyvitamin deficiency associated low testosterone levels men conflicting reports associations sex hormones women less known whether associations independent adiposity lifestyle factors whether differ race ethnicity aim examine associations concentrations sex hormone levels methods cross sectional analysis men women multi ethnic cohort main outcome measures testosterone estradiol dehydroepiandrosterone dhea sex hormone binding globulin shbg free testosterone results mean levels men women respectively men adjusting demographic lifestyle variables nem nmol decrease associated average difference nmol shbg percent free testosterone associated low total testosterone level nmol women decrease levels associated average difference nmol estradiol nmol shbg percent free testosterone nmol dhea significant interaction race ethnicity conclusions lower concentrations associated lower shbg levels higher free testosterone levels men women lower estradiol higher dhea levels women independent adiposity lifestyle observed significant association total testosterone men future studies needed determine whether vitamin supplementation influences sex hormone levels elsevier ireland ltd rights reserved
background ticks blood sucking arachnids feed classes vertebrates including humans ixodes holocyclus also known australian paralysis tick capable causing myriad clinical issues humans companion animals including transmission infectious agents toxin mediated paralysis allergic inflammatory reactions mammalian meat allergies humans australian paralysis tick endemic australia two exported cases reported literature case report report third exported case tick paralysis caused holocyclus imported patient singapore also discuss clinical course patient salient points management proper removal tick species emergency physician aware increasing air travel emergency physicians need aware identify imported cases tick paralysis institute proper management advice patient also describe tick identification features proper method removal tick species elsevier inc rights reserved
improve identification capability algorithm time varying sparse system propose block parallel swl dcd algorithm paper proposed algorithm first introduce norm constraint promote application sparse system second use shrinkage denoising method improve track ability third adopt widely linear processing take advantage non circular properties communication signals last reduce high computational complexity make easy implemented utilize dichotomous coordinate descent dcd iterations parallel processing deal tap weight update proposed algorithm verify convergence condition proposed algorithm also analyze steady state behavior several simulation done results show proposed algorithm achieve faster convergence speed lower steady state misalignment similar apa type algorithm apply proposed algorithm decision feedback equalizer dfe bite error rate ber decreases obviously
rivaroxaban apixaban increasingly used stroke prevention non valvular atrial fibrillation might impact platelet reactivity directly indirectly inhibition factor fxa preclude generation relevant thrombin amounts also block signalling fxa via protease activated receptors however weather fxa inhibition affects platelet haemostasis remains incompletely known one hundred twenty eight patients chronic anticoagulation either rivaroxaban apixaban least weeks included study time course group rivaroxaban apixaban venous blood samples taken noac medication intake morning well afterwards patients rivaroxaban apixaban blood samples drawn left atrial rfa procedures well min first heparin application rfa group platelet reactivity analyzed whole blood aggregometry multiplate analyzer roche response adp collagen trap aspi arachidonic acid altered rivaroxaban apixaban neither time course rfa group moreover soluble selectin thrombospondin von willebrand factor beta thromboglobulin plasma levels measured elisa showed statistically significant changes clinical settings either fxa inhibitor present study fails demonstrate significant changes platelet reactivity patients chronic rivaroxaban apixaban medication neither trough peak levels case haemostatic activation vivo depicted rfa procedures
two studies based stanley milgram original pilots present first systematic examination cyranoids social psychological research tools cyranoid created cooperatively joining real time body one person speech generated another via covert speech shadowing resulting hybrid persona subsequently interact third parties face face show naive interlocutors perceive cyranoid unified autonomously communicating person evidence phenomenon milgram termed cyranic illusion also show creating cyranoids composed contrasting identities child speaking adult generated words vice versa used study stereotyping person perception mediated inner dispositional outer physical identity results establish cyranoid method unique means obtaining experimental control inner outer identities within social interactions rich mundane realism
central aortic pressure cap used predict cardiovascular structural damage cardiovascular events development simple well validated non invasive methods cap waveforms estimation critical facilitate routine clinical applications cap existing widely applied methods generalized transfer function gtf cap method point moving average npma cap method based clinical practices lack mathematical foundation methods also inherent drawback personalisation missing individual aortic characteristics overcome pitfall present personalized model based central aortic pressure estimation method cap paper cap mathematical foundation human aortic network model proposed developed based viscous fluid mechanics theory could personalized conveniently via measuring pulse wave proximal distal ends radial artery least square method proposed estimate patient specific circuit parameters thus central aortic pulse wave obtained via calculating transfer function radial artery central aorta invasive validation study subjects comparing cap direct aortic root pressure measurements percutaneous transluminal coronary intervention carried beijing hospital experimental results show better performance cap method compared gtf cap method npma cap method illustrates feasibility effectiveness proposed method elsevier ltd rights reserved
united nations convention rights child crc spells many rights including right participate decision making within urban context child right city includes opportunity participate local governance youth councils ycs provide opportunities using nationwide survey united states paper describes characteristics accomplishments findings show ycs generally operate little funding commonly administered within parks recreation departments city council offices addition ycs created prior primarily addressed youth related problems whereas created focused leadership skills significant accomplishments reported ycs include development leadership skills knowledge government community based service projects conclusion considers impact ycs furthering goals crc giving youth access decision making
article describes creation application learning study material university west bohemia pilsen faculty mechanical engineering department machine design project specifically deals description design calculation construction universal center lathe study materials meet standards used modern engineering practice also appropriately structured better understanding documents created help experts field authors published elsevier ltd
graph colouring labelling elements graph subject certain constraints divided vertex edge colouring cases assignment labels traditionally called colours two vertices edges must colour graph colouring various applications especially parallel computing paper introduces degree six modified chordal ring chro parallel network interconnection topology model discusses node link colouring despite asymmetry chromatic number chro generalised must determined specifically based combination chords case cases chromatic index chro degree one colour degree generalised proven chromatic numbers important minimising completion times processes parallel processing reducing points synchronisation link colouring aids processor scheduling
personality disorders manifest stable deviations personality traits especially arise negative interactions others typical dysfunctional interactions observed particularly dissocial antisocial personality disorders adults severe forms personality disorders often showed specific symptoms childhood adolescence clinical researchers therefore demand respective diagnosis childhood adolescent psychopathy extensive body research dissocial borderline personality disorders children adolescents date severe form dissocial personality disorders psychopathy specifically classified transfer diagnosis childhood adolescence crucial based assumption persistence risk stigmatisation many clinicians refuse diagnose psychopathy young age hand positive treatment outcomes aim symptom reduction early age specification dissocial personality disorders childhood adolescence may encourage development new treatments stigmatisation well qualify dogged assumption persistence personality disorders
advancement phytochemical phytopharmacological sciences enabled elucidation composition biological activities several medicinal plant products including plant extract essential oils products widely used around world since ancient times treatment various disorders diabetes hypertension peptic ulcer disease microbial infection sexual disorder many popularity modern system medicine mainly due availability fewer adverse reactions compared synthetic drugs various scientifific investigations conducted look potential extract plant isolated compounds continued use products treatment prevention various kinds human diseases evident available literature scientifific investigations many plant species possess potential use benefificial therapeutic remedy multiple pharmacological actions analgesic anti inflflammatory antipyretic hypoglycemic hypotensive antimicrobial antiulcer anticonvulsant activities present review aims provide relevant updated information certain plant products composition preparation fungicidal fungistatic effects different species fungus evaluated studies done past introduces six medicinal plants studied antifungal property found effective overall objective provide comprehensive information use plant extract essential oil treating fungal infections explore evidence supporting effectiveness treating fungal diseases without causing serious adverse reactions
objective assess role oral pentosan polysulphate pps reduction bacille calmette guerin bcg related local side effects patients high grade non muscle invasive bladder cancer nmibc patients methods total symptomatic patients receiving bcg instillation randomized three groups group received placebo vitamin complex tablet thrice daily group received pps thrice daily group received pps daily placebo vitamin complex tablet twice daily weeks visual analogue scale vas score bladder pain overactive bladder validated question screener oab scores dysuria evaluated three groups weekly visit bcg instillation results mean post treatment vas scores significantly lower groups group addition post treatment vas score significantly lower group group mean post treatment oab score significantly lower group decreased dysuria decreased groups persisted group conclusion present study shows oral pps thrice daily effective relieving bcg related local side effects
distributed video coding dvc provides different compression paradigm consists lightweight encoder complex decoder compression paradigm shed light nowadays mobile devices equipped limited battery computing resources corresponding multimedia service backed cloud computing infrastructures years developing coding performance decoding speed dvc still facing serious challenges example dvc rate distortion performance far behind traditional prediction based video codec required decoding complexity handicaps value practical usage order meet challenges propose efficient real time dvc framework progressive side information regeneration taking gpgpu based parallel computing account proposed system resolve one achilles heels large group picture scenario dvc codec good performance much improved decoding speed bjontegaard delta peak signal noise ratio improvement system compared discover codec also comparable state art optical flow based dvc codecs average decoding speed goes frames per second fps even fps hall sequence best knowledge first dvc codec tackles performance decoding speed issues simultaneously
information technology contributing various areas knowledge particular field education stands concerns teaching computer programming literature contains important efforts aim assist learning process teaching algorithms programming concepts first year students always great challenge universities new computer science students usually difficulties understanding abstracting problem logics alternative contributed teaching learning process use learning objects contribute towards mediating enhancing teaching learning process one great difficulties learning initial semesters engineering computer science courses related contents computer programming increases students failure level also dropout rate courses order decrease rates developed project create various learning objects help teach concepts considered difficult understand students science courses results positive paper presents qualitative quantitative results experiment conducted development application learning objects help teaching students computer science project conducted outcome data showed use learning objects contributes significantly teaching learning process
melatonin mlt serotonin two biosynthetically related compounds implicated several common physiological functions etiology mood disorders interact though yet fully understood study single unit extracellular recordings used monitor dorsal raphe nucleus neuronal activity anesthetized rats basal conditions ctrl response mlt administration pinealectomy across light dark cycle basal conditions number spontaneously active neurons firing rate significantly lower dark phase light phase administration mlt low doses decreased firing activity inhibitory effect mlt completely blocked receptor antagonist luzindole selective receptor antagonist pdot selective hta receptor antagonist way alpha adrenoceptor antagonist idazoxan opposite experiment increased firing activity dark phase reversed mlt administration finally forced swim test mlt increased immobility time decreased swimming behavior together results suggest nocturnal mlt secretion imposes tonic inhibitory control sub population neurons mlt induced decrease neurotransmission may represent biological mechanism underlying mood disorders characterized increased mlt secretion seasonal affective disorder
recently degree freedom dof based models widely used study mimo network performance existing dof based models differ interference cancellation behavior many suffer either loss solution space possible infeasible solutions overcome limitations new dof based model employs scheme based node ordering proposed paper apply new dof model study throughput maximization problem multihop mimo network problem formulation involves joint consideration flow routing dof allocation falls form mixed integer linear program milp main contribution efficient polynomial time algorithm offers competitive solution milp series linear programs lps algorithm employs sequential fixing framework obtain initial feasible solution improves solution exploiting impact node ordering dof consumption node route diversity network simulation results show solutions obtained proposed algorithm competitive feasible
paper small remote area located nigeria considered model tested managing scheme providing electricity water strategy groundwater pumped water tank later used supplying required irrigation drinking water pat pump turbine used hybrid system supplying electricity water well storing water water tank also photovoltaic plant package batteries bat addition diesel ice internal combustion engine used optimized along best size devices managing system purpose obtaining maximum economical operating strategy paper two cases considered assess effectiveness system study firstly mentioned devices used show internal combustion engine system dominates components due low cost fuel second case renewable resources exploited optimized order make renewable system least possible cost variables makes problem complicated requires solved algorithm accuracy therefore mgsa modified gravitational search algorithm adapted mutation tactic used find best cost management strategy first case although cost diesel oil low using pat diesel oil consumption reduced second case order make renewable system size enlarged approximately times comparison first case hybrid pat storing structure capable deliver water irrigation domestic requirements well electricity needed rural community elsevier ltd rights reserved
addition economics reliability environmental emissions great importance designing power generation system objective study optimally design autonomous non autonomous hybrid green power system hgps supply specific load demand considerations economics reliability indices environmental emissions hgps includes wind turbine units photovoltaic arrays electrolyzer fuel cell data used simulation actual annual solar irradiation wind speed northwest region iran reliability analysis assumed convertor electrical network failure supplying power imperial competitive algorithm utilized optimization address different levels importance economics environmental emission fuzzy multi objective problem formulation used non autonomous hgps optimally designed non autonomous hgps maximum purchased power based current rates costs less autonomous hgps exchange tons emissions general determined allowance purchasing power results lower overall efficiency non autonomous hgps elsevier ltd rights reserved
adsorption behavior unstable proteins bovine serum albumin alpha lactalbumin studied hydrophobic interaction chromatography medium mass overloading conditions different kosmotropic salt concentrations mobile phase mechanistic model formulated used describe kinetics thermodynamics protein interactions adsorbent surface model assumed two site binding adsorption reversible protein unfolding allowed predicting inhibition protein unfolding high column loadings simplified procedure determination model parameters developed based inverse method model successfully used reproduce pattern chromatographic elution well course breakthrough curves model formulation supported nano differential scanning fluorimetry measurements exploited determine protein stability liquid adsorbed phases different column loadings salt concentrations elsevier rights reserved
background contrary dsm definition based recurrence low grade hypomanic depressive symptoms cyclothymia better defined neurodevelopmental perspective exaggeration cyclothymic temperament emotional dysregulation extreme mood instability reactivity core features complex symptomatology method present article critically reviewed literature diagnosis treatment cyclothymia focusing temperamental neurodevelopmental perspectives results current epidemiological clinical research showed high prevalence validity cyclothymia distinct form bipolarity frequently associated multiple comorbidities anxiety impulse control substance use called personality disorders many patients receive correct diagnosis treatments many years illness superposition complications reduces possibility complete remission therapeutic model combining focus symptomatic presentations temperamental perspective seems represent effective approach cyclothymic patients complex clinical presentations conclusion cyclothymic mood instability understudied issue despite evidence clinical relevance unresolved issues concern diagnostic delimitation possible relationships emotional dysregulation observed neurodevelopmental disorders need confirm specificity disorder improve recognition early phase life especially youth early recognition means avoiding unnecessary complications establishing specific treatments clinical management since beginning
throughout united states rise public discourse transgender people transgender issues much attention stems passed proposed anti lgbtq lesbian gay bisexual transgender queer questioning legislation including bathroom bills would require transgender people use public facilities corresponding sex designated birth certificates recent discussion legislation impacting school aged children adolescents mean school nurses care advocate transgender students article aim empower school nurses join discussion advocate inclusive equitable school policies deliver gender affirming care transgender students explain transgender identities transgender related stigma prejudice discrimination health concerns gender affirming approaches caring transgender youth implications school nurses school nurses play key role creating space welcoming affirming transgender students thrive
purpose paper study design opportunities high speed toothless toroidal winding surface permanent magnet machine enabled implementation silicon carbide based power electronic inverters high speed machines designed toothless toroidal winding configuration beneficial eliminating cogging torque due absence stator teeth airgap flux density reduced inductance small due large equivalent airgap hand high pole count toroidal winding electric machines advantages less total weight volume low pole count machines however high fundamental frequency required high pole count machine challenging meet silicon based power electronic drives limited switching frequency silicon carbide based devices fast switching capability due mosfet characteristics replace silicon igbts high voltage applications greater using silicon carbide based power electronic drives two challenges low inductance high fundamental frequency requirement high pole count toothless toroidal winding machines overcome research studies presented paper show implementation silicon carbide based drives reduces current harmonic distortion high pole count toothless toroidal winding machine makes feasible high speed operation low inductance high current ripple issues mitigated
localization tracking resources construction jobsites emerging area location materials labor equipment used estimate productivity measure project progress enhance jobsite safety gps widely used outdoor tracking construction operations however gps suitable indoor applications due lack signal coverage particularly inside tunnels buildings several indoor localization research studies attempted however developments rely heavily extensive external communication network infrastructures developments also susceptible electromagnetic interference noisy construction jobsites paper presents indoor localization system using microcontroller equipped inertial measurement unit imu imu contains cluster sensors accelerometer gyroscope magnetometer microcontroller uses direct cosine matrix algorithm fuse sensors data calculate non gravitational acceleration using nine degrees freedom motion equations current position calculated based measured acceleration heading accounting growing error speed estimation utilizing jerk integration algorithm experimental results presented illustrate relative effectiveness developed system able operate independently external aids visibility conditions elsevier rights reserved
objectives evaluate impact risk factors associated abnormal exercise test systemic inflammatory rheumatic disease sird patients commencing supervised physical exercise methods total sird patients enrolled three controlled clinical trials including sle patients control group consisted healthy sedentary subjects matched age gender bmi performed according bruce ellestad protocol cardiovascular disease risk factors medications comorbidities details sird assessed results sird patients higher percentage abnormal ets compared control group especially exercise hypertensive behaviour higher oxygen consumption higher resting heart rate heart rate first minute recovery chronotropic incompetence inc disease involved higher likelihood abnormal odds ratio sle year increment age increased chance abnormal patients well hypertension regarding inc age played protective role sle asdas esr associated higher risk conclusion results showed higher prevalence abnormal ets asymptomatic cardiovascular sird patients disease associated higher likelihood abnormal test emphasizing relevance need performing starting supervised physical exercise
heat stress dry period affects cow mammary gland development metabolism immunity transition period however effect late gestation heat stress calf performance immune status unknown objective evaluate effect heat stress final similar gestation growth immune function calves calves treatment born cows exposed cooling heat stress dry period heifer calves used measurements growth immune status birth heifer calves managed identical conditions fed colostrum respective dams within birth weaned age moa body weight obtained weaning monthly moa withers height measured monthly moa hematocrit plasma total protein assessed birth age total serum igg evaluated age apparent efficiency absorption calculated peripheral blood mononuclear cells isolated age proliferation rate measured thymidine incorporation vitro blood cortisol concentration measured darns dry period calves preweaning period gestation length shorter cows compared cows calves cows greater calves cows birth compared heifers heifers decreased weaning similar moa compared heifers cows less total plasma protein total serum igg apparent efficiency absorption tended decreased hematocrit additionally heifers greater peripheral blood mononuclear cell proliferation relative heifers fold compared late gestation affect blood cortisol concentration darns dry period calves preweaning period calves tended increased circulating cortisol birth conclude heat stress dam dry period compromises fetal growth immune function offspring birth weaning
background vulnerability reduction natural light associated fall winter generally accepted main trigger seasonal affective disorder sad whereas light therapy treatment choice disorder however relationship exposure light mood regulation remains unclear compared green light blue light shown acutely modulate emotion brain processing healthy individuals investigated impact light emotion brain processing patients sad healthy control subjects relationship retinal light sensitivity methods fourteen symptomatic untreated patients sad years women healthy control subjects years women performed auditory emotional task functional magnetic resonance imaging fall winter season exposed alternating blue green monochromatic light scotopic photopic retinal light sensitivities evaluated electroretinography results blue light enhanced responses auditory emotional stimuli posterior hypothalamus patients sad whereas green light decreased responses effects blue green light observed healthy control subjects despite similar retinal sensitivity sad control subjects conclusions results point posterior hypothalamus neurobiological substrate involved specific aspects sad including distinctive response light altered emotional responses
objective sport participation shows overall trend decline age statistics canada transition adulthood often threatening athletes decision continue sports lim study explored role community sport clubs facilitating sport participation throughout youth adult transition among non elite athletes design study part larger project guided case study design method eight non elite athletes males females successfully transitioned youth adult community club rugby canada largest city engaged semi structured interviews data analyzed thematic analysis braun clarke results clubs first played important role prior transition drawing youth clubs clubs built sense loyalty sport commitment identity throughout youths transition young adulthood fostered appealing club philosophy atmosphere supportive team mates opportunities senior junior adult youth mentorship clubs strategies athletes continued involvement adulthood included gradual introduction senior adult level focus skill development fitness health flexibility programming providing opportunities leadership roles conclusions findings discussed lens transition adaptation models well sport participation development findings highlight practical implications promoting long term sport participation among non elite athletes emphasize importance research exploring trajectories non elite athletes successfully less successfully transition adult sport elsevier ltd rights reserved
data storing sharing requirement database becomes important industrial control software point scheme proposed design database first object oriented technology applied design data structure real time database designed direct memory address technology historical database built structured storage technology last interface historical database client application designed based com technology
extreme learning machine elm well known algorithm training neural networks two modes functionality regression classification paper presents novel model using elm ciphering study begins investigation real time recurrent neural network rrnn derived gradient based learning symmetric cipher weakness cipher error converges zero rrnn change regardless plaintext changed given nature elm technique elm based cipher proposed provide capability performing training independently input error gradient different simulation scenarios used evaluate validate effectiveness proposed cipher results revealed elm based cipher performed better rrnns especially terms security moreover elm based cipher demonstrated significantly competing performance wide range evaluation measures using elm based cipher instead aes type ciphers added advantage providing addition level securityby allowing user change algorithmic core cipher simply changing weights neural network allows hardware programmed ciphers secure costing less compared ciphers copyright john wiley sons ltd
high throughput screening generates large volumes heterogeneous data require diverse set computational tools management processing analysis building integrated scalable robust computational workflows applications challenging highly valuable scientific data integration pipelining facilitate standardized data processing collaboration reuse best practices describe jenkins shelf open source continuous integration system used build pipelines processing images associated data high content screening hcs jenkins provides numerous plugins standard compute tasks design allows quick integration external scientific applications using jenkins integrated cellprofiler open source image processing platform various hcs utilities high performance linux cluster platform web accessible facilitates access sharing high performance compute resources automates previously cumbersome data image processing tasks imaging pipelines developed using desktop cellprofiler client managed shared centralized jenkins repository pipelines managed data annotated facilitate collaboration reuse limitations jenkins primarily around user interface addressed selection helper plugins jenkins community
hydrogen sulphide endogenously produced vascular tissue anti oxidant vasoprotective properties study investigates whether chronic treatment using fast donor nahs could elicit vasoprotective effect diabetes diabetes induced male cbl mice streptozotocin daily weeks confirmed elevated blood glucose glycated haemoglobin levels diabetic mice treated nahs mol day weeks aortae collected functional biochemical analyses diabetic group endothelium dependent vasorelaxation basal nitric oxide center dot bioactivity significantly reduced maximal vasorelaxation center dot donor sodium nitroprusside impaired aorta compared control mice vascular superoxide generation via nicotine adenine dinucleotide phosphate nadph oxidase elevated aorta diabetic mice associated increased expression nox nahs treatment diabetic mice restored endothelial function exogenous center dot efficacy back control levels nahs treatment also reduced diabetes induced increase nadph oxidase activity affect nox protein expression data show chronic nahs treatment reverses diabetes induced vascular dysfunction restoring center dot efficacy reducing superoxide production mouse aorta
previous studies biological genetic evidence indicate myo inositol monophosphatase impa gene may influence schizophrenia performed genetic association study han chinese cohorts five single nucleotide polymorphisms within impa promoter region well one intron positively associated another study selected genotyping patients schizophrenia mentally healthy controls genotype allele frequencies assessed gender stratification interestingly showed strong association schizophrenia allele frequent cases controls vitro promoter assay showed transcription activity allele promoter higher allele promoter allele contributed risk schizophrenia stratifying males females found gender specific association impa schizophrenia allele frequent male cases compared male controls data suggest promoter polymorphism impa possibly contributed risk schizophrenia elevating transcription activity han chinese individuals
floods impose significant risk buildings sustainability due climate changes issue becomes topic areas among various categories cultural heritage especially vulnerable assets reproduced contribution discusses results ongoing research project focused protection cultural heritage flood danger one crucial goals project design development methodology supporting software application analysing building materials vulnerability floods research several experts various areas materials engineering contributed extensive knowledge base covering important materials related immovable constructs movable objects model designed goal transformed formalised computer model enables development knowledge system system prototyped finalized end users offers users perform customised analysis building consisting general aspects building location together sophisticated details inner building constructions movable objects
mhd free convection inclined plate thermally stratified high porous medium presence magnetic field studied dimensionless momentum temperature equations solved numerically explicit finite difference technique help computer programming language compaq visual fortran obtained results studies discussed different values well known parameters different time steps also stability conditions convergence criteria explicit finite difference scheme analyzed finding restriction values various parameters get accuracy effects various governing parameters fluid velocity temperature local average shear stress nusselt number investigated presented graphically authors published elsevier ltd
evaluating performance distributed systems real experimentation resource consuming essence difficult reproduce conversely analytical modeling simulation facilitate investigation level realism needs evaluated avoid misinterpretation paper combine production experiments realistic simulation performance modeling optimization application workflows deployed european grid infrastructure egi one largest distributed systems world use validated simulator exhaustively evaluate analytical model application makespan study influence calibrate parameters application workflow particular checkpointing period experimental results show model fits simulated makespan relative error simulation allows validate analytical models exhaustive manner possible production experiments results also show provided simulator correctly validated instantiated simulation safely used exhaustive parameter studies allowing quick fine tuning sensitive application parameters elsevier rights reserved
epidemiological studies shown patients psoriatic arthritis psa often affected numerous comorbidities carry significant morbidity mortality reported comorbidities include diabetes mellitus obesity metabolic syndrome cardiovascular diseases osteoporosis inflammatory bowel disease autoimmune eye disease non alcoholic fatty liver disease depression fibromyalgia health care providers patients psa recognize monitor comorbidities well understand effect patient management ensure optimal clinical outcome
empirical analysis data drawn european social survey reveals individual characteristics controlled women engaging market work housework similar life satisfaction levels complementing micro level data survey country level variables namely gdp per capita gender inequality measured world economic forum global gender gap index gggi estimate multilevel regression model shed light contextual factors life satisfaction women europe find working women well relative housewives greater countries gggi indicates smaller gender gap women better position terms equality men public domains interpret finding mean called paradox declining female happiness part due persistent gender roles appear larger impact well working women
fire whirls powerful spinning disasters people surroundings occur large urban wildland fires whereas fire whirls studied fire safety applications previous research yet harness potential burning efficiency enhanced combustion article presents laboratory studies fire whirls initiated pool fires fuel sits water surface suggesting idea exploiting high efficiency fire whirls oil spill remediation show transition pool fire fire whirl previously unobserved state blue whirl blue whirl smaller stable burns completely blue hydrocarbon flame indicating soot free burning combination fast mixing intense swirl water surface boundary creates conditions leading nearly soot free combustion worldwide need reduce emissions wanted unwanted combustion discovery state points possible new pathways reduced emission combustion fuel spill cleanup current methods generate stable vortex difficult also propose blue whirl may serve research platform fundamental studies vortices vortex breakdown fluid mechanics
magnetic shape memory alloy msma relatively new kind smart material upon application large magnetic field exhibits actuation strains similar thermal shape memory alloy sma shows significantly reduced response time millisecond range currently application restricted brittleness single crystal material nonlinear behaviour difficulty generate apply magnetic field around order exploit full actuation potential focus work design miniaturized magnetic circuits bulk msmas various circuit designs compared toroidal series parallel shapes equivalent circuit well finite element simulation used increase magnetic field characteristic air gap smart material placed symmetrical toroid coil layout msma element center allows easy integration actuator various applications described static characterization results actuator provided using described magnetic circuit msma rods dimensions xmm peak displacement blocked force obtained design guidelines miniaturized actuators given
order satisfy requirements productivity quality recent years laser welding processes certain grades steels mainly thin sheets assemblies tailored welded blanks twbs given many successful advantages manufacturing engineering welding process particular makes possible easily joint steel parts thickness grade identical different many industrial applications car industry pipe lines tubes etc additionally interstitial free steels low contents successfully developed order perform specific complex deep drawing operations automotive industry major developments twb means laser welding area also occurred certain grades steel particularly suitable deep drawing operations twb due high values lankford ratio grumbach sanz ductile brittle tests impact tensile test itt metall bayraktar kaplan buirette grumbach application impact tensile testing welded thin sheets mater process technol bayraktar kaplan hugele jansen evaluation pipe line laser girth weld properties charpy impact tensile tests mater process technol bayraktar kaplan grumbach application impact tensile testing spot welded sheets mater process technol however narrowness weld bead important hardness gradient determination toughness definition criterion ductile brittle transition impact test welded connection weld bead heat affected zone confirm delicate laser welding main objective paper make comparative study microstructural mechanical toughness characterisation steel assemblies base metal welded laser procedure test specifically adapted used welded joints first part study consider different steel grades grade febfn steel grade interstitial free steel welded laser largely used automotive industry elsevier rights reserved
study aimed establish whether family characteristics health behaviour illnesses parents children associated public health nurses phns concerns children physical health psychosocial development context health examinations factors affecting children health well identified early possible provide children families appropriate support cross sectional study finland collected information phns concerns children health well well background factors affecting health examinations preschool age children school aged children associations family characteristics parents children behaviour diseases phns concerns assessed using logistic regression analysis overweight children long term illnesses children parents parental smoking factors strongly associated phns concerns child physical health whereas non nuclear family types father low educational level unemployment child lack sleep bullying associated concerns child psychosocial development connections found demonstrate health examinations address factors affect whole family well comprehensively promote children health growth development
xpd ercc gene encodes dna helicase involved dna repair transcription patients mutations xpd may different autosomal recessive phenotypes including trichothiodystrophy ttd xeroderma pigmentosum ttd patients sulfur deficient brittle hair short stature developmental delay contrast patients freckle like pigmentation greatly increased risk sun induced skin cancers mothers ttd patients reported high frequency pregnancy neonatal complications performed molecular epidemiological study mothers ttd patients mothers patients xpd mutations found ttd pregnancies pre term delivery pre eclampsia hemolysis elevated liver enzymes low platelets hellp syndrome prematurity low birth weight none pregnancies complications mutations xpd may differential effects dna repair transcription observations provide insights role xpd human pregnancy fetal development european journal human genetics doi ejhg published online may
background distinguishing pediatric bipolar disorder attention deficit hyperactivity disorder adhd challenging hyperactivity core feature disorders severely disturbed sleep circadian dysregulation characteristic least adults tested hypothesis objective measures activity sleep circadian rhythms would help differentiate pediatric subjects adhd typically developing controls methods unmedicated youths males age diagnosed using dsm criteria kiddie sads youths compared typically developing controls children adhd adhd plus comorbid depressive disorders three five days minute minute belt worn actigraph data ambulatory monitoring inc collected school week processed yield metrics per subject assessed group differences analysis covariance cross validated machine learning algorithms used determine predictive accuracy four parameter model measures reflecting sleep hyperactivity circadian dysregulation plus indic bipolar vulnerability index results prominent group differences several activity measures notably mean lowest hours activity skewness diurnal activity relative circadian amplitude predictive support vector machine model discriminated bipolar non bipolar mean accuracy roc area kappa specificity sensitivity conclusions objective measures sleep circadian rhythmicity hyperactivity abnormal wearable sensor technology may provide bio behavioral markers help differentiate children adhd healthy controls
carriers fragile premutation fpm cgg trinucleotide repeat expansions utr fmr compared cgg repeat length general population carriers thought without symptoms recognized develop variety early neurological symptoms well risk developing late onset neurodegenerative disorder fragile associated tremor ataxia syndrome fxtas several mouse models contributed understanding fpm fxtas findings studies using models summarized review also discusses information improving understanding molecular cellular abnormalities contribute neurobehavioral features seen fpm carriers patients fxtas mouse models show much pathology seen fpm carriers individuals fxtas including presence elevated levels fmr mrna decreased levels fragile mental retardation protein ubiquitin positive intranuclear inclusions abnormalities dendritic spine morphology several brain regions associated neurocognitive deficits spatial temporal memory processes impaired motor performance altered anxiety vitro studies identified altered dendritic synaptic architecture associated abnormal dynamics electrical network activity fpm mice particularly useful understanding roles fmr mrna fragile mental retardation protein translation potentially toxic polyglycine peptide pathology finally potential using emerging mouse models preclinical development therapies improve neurological function fxtas considered
patients severe mental illnesses manifest substantial deficits self assessment abilities impact everyday functioning study compares patients schizophrenia healthy individuals social cognitive performance assessment performance convergence performance indicators effort solving tasks patients schizophrenia healthy controls completed bell lysaker emotion recognition test blert psychometrically sound assessment emotion recognition participants rated confidence accuracy responses item participants instructed respond rapidly possible without sacrificing accuracy time complete item recorded patients schizophrenia performed less accurately blert patients confident items correctly answered items errors patients less confident overall significant interaction confidence group accuracy demonstrated substantial adjustment response time task difficulty taking considerably longer solve items got wrong whereas patients showed minimal adjustment results expand knowledge self assessment social cognitive performance ability appraise difficulty adjust effort social cognitive task demands patients schizophrenia elsevier rights reserved
big data technology developed management data large volumes different varieties data would processed optimal velocity data dealt may structured unstructured relational databases spreadsheets typical examples structured data methods well techniques researches relational database management well known paper describe formalism structured data considered directly generalized model relational databases higher leveled structured data generalization defined recursively set queue lower leveled structured data consequently study proves many concepts results relational database management transferred structured data accordingly generalization sub data components structured data functional dependencies structured data well keys data structured data defined studied alternately concepts defined structured data applied relational databases special case paper operations structured data homomorphism structured data defined studied appear quite suitable relational databases fact formalization introduced offers effective methods structural algebraic researches structured data
herein two classic animal behavior despair tests forced swim test tail suspension test used evaluate antidepressant like activity saringosterol sargassum fusiforme mice saringosterol found significantly shorten immobility time forced swim test tail suspension test doses mice measurement locomotor activity indicated saringosterol central nervous system stimulating effects addition found saringosterol significantly increased noradrenaline serotonin metabolite hydroxyindoleacetic acid mouse brain suggesting antidepressant like activity may mediated neurotransmitters
know electrical power losses electrical network established perimeter adopt measures order obtain decrease represent important problems electrical networks exploitation maintenance thus paper aims realize model medium voltage network belonging electrical station centre urban area cluj napoca order determine technological consumption model established zone performed using paladin designbase determining time self technological consumption stc entire network several situations also different scenarios proposed paper starting normal operating scheme another target authors determine optimum specific methods obtain higher efficiency end users suplying considered area
psychiatric evaluation presents significant challenge conceptually integrates input multiple psychopathological approaches recent technological advances study protein structure function interactions provided breakthrough diagnosis treatment mood disorders identified novel biomarkers used indicators normal disease states response drug treatment investigation biomarkers psychiatric disorders enzymes catechol methyl transferase monoamine oxidases neurotransmitters dopamine serotonin norepinephrine receptors particularly involvement neuroendocrine activity brain structure function response psychotropic drugs facilitate diagnosis clinical settings prognostic biomarkers may revealed analyzing serum saliva cerebrospinal fluid promote timely diagnosis personalized treatment mechanisms underlying activity currently used drugs based functional regulation proteins including receptors enzymes metabolic factors study analyzed recent advances identification biomarkers could used timely diagnosis treatment stratification prediction clinical outcomes
opiates still effective widely used treatments acute chronic pain however problems associated morphine standard opioid analgesics severely limit effectiveness clinic ppl ppl derived morphine morphinan ring systems contain chiral substituent confers unique combination high binding affinities partial agonist activities delta kappa opioid receptors leading unique vivo pharmacology compared conventional opioids acute antinociceptive reward acquisition ppl ppl assessed mice using tail flick assay conditioned place preference cpp paradigm respectively reinforcing effects compounds assessed rats using self administration paradigm mice ppl ppl produced antinociception reaching maximal effects equivalent morphine approximately morphine dose respectively ppl induced antinociception attenuated following pretreatment kappa antagonist jdtic opioid antagonist beta fna mice ppl ppl produced dose dependent decreases activity similar kappa agonists however produce conditioned place aversion fact elicited trend toward cpp rats neither ppl ppl self administered substituted morphine ppl attenuated morphine self administration administered systemically prior self administration session collectively results indicate mixed opioid receptor partial agonists produce potent antinociceptive activity lack aversion mice without self administered rats compounds profile could superior analgesics greatly reduced addiction liability fewer side effects compared traditional opiates
objectives although acupuncture microcurrent widely used chronic pain remains considerable controversy therapeutic value neck pain aimed determine effect size microcurrent applied lower back acupuncture points assess impact neck pain design cohort analysis treatment outcomes pre postmicrocurrent stimulation involving patients history nonspecific chronic neck pain subjects settings consenting patients enrolled group therapists attending educational seminars asked report pain levels pre post hours single mps application interventions measurements direct current microcurrent point stimulation mps applied standardized lower back acupuncture protocol points used evaluations entailed baseline visual analog scale vas pain scale assessment using vas repeated twice therapy immediately postelectrotherapy follow period patients received single mps session results analyzed using paired tests results outcomes pain intensity showed initial statistically significant reduction points mean neck pain levels standard protocol treatment compared initial pain levels statistically significant reduction mean neck pain levels compared pain levels immediately standard protocol treatment points total average pain relief conclusions positive results study could applications patients impacted chronic neck pain
sunitinib tyrosine kinase inhibitor tki used treatment metastatic renal cell carcinoma mrcc gastrointestinal stromal tumors pancreatic neuroendocrine tumors one common side effects related sunitinib hypothyroidism recent trials suggest correlation incidence hypothyroidism treatment outcome patients treated tki study evaluates whether development hypothyroidism predictive marker progression free survival pfs patients mrcc treated sunitinib twenty seven patients diagnosed clear cell mrcc nephrectomy good intermediate mskcc risk prognostic group included study patients received sunitinib first line treatment standard schedule initial dose day weeks weeks thyroid stimulating hormone serum levels obtained baseline every weeks treatment statistic analyses used kaplan meier method assessment progression free survival comparison survival used log rank test study incidence hypothyroidism patients developed hypothyroidism better median pfs patients normal thyroid function months months versus months months survival analysis perceive thyroid dysfunction predictive factor progression free survival pfs unified group patients development hypothyroidism treatment sunitinib positive marker pfs treatment thyroid function evaluated regularly
smart materials structures emerging revolutionary technology requiring multidisciplinary training fields aerospace mechanical materials engineering important educate undergraduate graduate students fundamentals applications technology curriculum designed university maryland introduce students materials addition general overview smart materials structures laboratory lecture case study piezoelectric actuated beam developed laboratory experiments used determine bending modal frequencies mode shapes cantilevered beam actuation piezoceramics tests conducted smart structures laboratory university maryland regular lecture length class times using existing equipment results experiment compared exact numerical solutions vibration frequencies uniform rectangular beam case study proved excellent learning tool shown lab data correlation positive student reviews
kikuchi fujimoto disease kfd rare self limiting disorder typically affects cervical lymph nodes lns although initially described young women kfd also occurs men reports clinical manifestations characteristics male kfd patients therefore study conducted assess incidence kfd among males well frequent clinical characteristics patients retrospective cross sectional study performed tertiary hospital patients pathologically confirmed kfd biopsy specimens clinical laboratory data treatment outcomes enrolled patients analyzed gender total patients diagnosed kfd enrolled females males mean age years compared female patients males frequent manifestations fever headache bilateral lymphadenopathy thrombocytopenia elevated reactive protein crp elevated liver enzymes elevated lactate dehydrogenase ldh male patients fewer autoimmune features fewer positive antinuclear antibodies study enrolled patients male female male sex ratio male patients showed distinctive profile characterized higher frequency fever headache bilateral lymphadenopathy thrombocytopenia well elevated liver enzymes crp ldh
single nucleotide polymorphisms snps within dna region containing interferon lambda ifnl ifnl genes prognostic factors treatment response chronic hepatitis chc iron overload frequently diagnosed chc associated unfavorable disease course risk carcinogenesis etiology relationship immune response chc fully explained aim determine whether ifnl polymorphisms chc patients associate body iron indices whether linked hepatic expression genes involved iron homeostasis ifn signaling chc patients four snps within ifnl ifnl region genotyped liver biopsies histopathological analyses performed expression five mrnas three long non coding rnas lncrnas determined qrt pcr liver samples genotypes well markers serum hepatocyte iron overload associated higher activity gamma glutamyl transpeptidase liver steatosis presence two minor alleles tested snps predisposed abnormally high serum iron concentration correlated higher hepatic expression lncrna nrir hand homozygosity major allele associated higher viral load patients bearing genotype lower hepatic expression hepcidin hamp hamp mrna level positively correlated serum iron indices degree hepatocyte iron deposits ifnl polymorphisms influence regulatory pathways cellular response ifn affect body iron balance chronic hepatitis virus infection
background substance use disorder sud important health problem requires complex range care chronic nature disorder multiple psychosocial problems involved current outpatient programs often difficulties delivering coordinating ongoing care access different healthcare providers various case management models developed first patients psychiatric domains patients sud order improve treatment outcomes aim paper aims assess effectiveness patients sud methods performed systematic review interventions patients sud analyzing randomized controlled studies published subject found electronic database pubmed results conclusion fourteen studies included analysis differences studies outcome measures populations included intervention characteristics made difficult compare results studies reported improvement chosen outcomes treatment adherence mostly improved substance use reported decrease third studies overall functioning improved half studies heterogeneity results might linked differences studies research needed field
previous studies reported numerous correlations psychopathy various personality traits behavioural tendencies clinical characteristics present study examined greater depth relationships components psychopathy measured psychopathy checklist revised pcl intelligence well impulsivity total ninety male violent offenders recruited prison forensic psychiatric hospital germany subjects assessed using pcl barratt impulsiveness scale bis short version german wechsler adult intelligence scale wip expected canonical correlation analysis showed negative association spatial intelligence factor subtotal pcl reckless lifestyle antisociality addition results agreed assumption association impulsivity subtotal pcl factor positive relationship verbal intelligence subtotal factor pcl insincere manipulative conduct affective deficits vanished controlling educational level results indicate relationship spatial components intelligence concept psychopathy described hare result supports spatial impairment aetiological model antisocial behaviour elsevier ltd rights reserved
taken individually ground source heat gsh pervious paving systems pps rainwater harvesting new combination energy water blend relatively recent sealed impermeable geomembrane pps becomes water harvesting tank installing gsh collectors base potential sustainably heat cool buildings provide flood resilience improve water quality review literature found coefficients performance suggest systems could considered viable reaching value required renewable energy directive small scale laboratory based test rigs combined system able reduce pollutants biological oxygen demand ammonia nitrogen rare occurrences potentially pathogenic bacteria legionella low survival rates escherichia coli whilst test rigs provide valuable information field monitoring building scale way validate technology thus paper presents previously unpublished results monitoring combined system building scale found clear potential use clean renewable sustainable source heat time providing flood resilience water quality improvements amenity domestic setting however also found seasonal changes building use affected levels comfort achievable lessons learnt construction strategies optimise design including depth heat collectors optimal surface area pps available infiltrate water elsevier ltd rights reserved
adsorption chiller refrigerant water operating pressure low kpa cooling power generation flooded evaporator affected height water column resolve issue experimentally investigate performance flooded evaporator function water height results show optimum water height equal tube diameter leading achieve highest cooling power condition internal external thermal resistances inside outside evaporator tubes account overall thermal resistance reduce internal thermal resistance twisted type turbulent flow generators incorporated evaporator tubes evaporator cooling power shows increase twisted tape type turbulators used cost increase internal pressure drop times respectively twisted tape type turbulators improve average specific cooling power adsorption chiller respectively reduce external thermal resistance outside surface evaporator tubes coated porous copper coated evaporator increases overall heat transfer coefficient times improves specific cooling power adsorption chiller compared uncoated tubes elsevier ltd rights reserved
research proposed novel development dof infinity loop shaping structured controller based particle swarm optimization pso considers closed loop dynamic response robustness stability minimal control input design criteria control position dof pneumatic surgical robot unlike conventional infinity controllers proposed controller offers robustness high performance cost effective simple structure recently received attention several researchers preferred industrial applications proposed technique simulated experimented nonlinear system pneumatic dof surgical robot minimally invasive surgery mis mechanical design dynamics modeling system identification surgical robot conducted simulation results verify proposed controller gain better infinity sub optimal solution conventional dof infinity loop shaping controller also experiments confirm proposed controller capable tolerate perturbed conditions alternative conventional controllers pneumatic controlled system elsevier ltd rights reserved
impairments executive functioning give rise reduced control behavior impulses therefore risk factor violence criminal behavior however contribution specific underlying processes remains unclear crucial element executive functioning essential cognitive control goal directed behavior visual attention elucidate importance attentional functioning general offender population employed attentional capture task measure visual attention expected offenders impaired visual attention revealed increased attentional capture compared healthy controls comparing performance offenders healthy community controls found hypothesis partly confirmed offenders accurate overall accurate absence distracting information suggesting superior attention presence distracting information offenders significantly less accurate compared distracting information present together findings indicate violent offenders may superior attention yet worse control attention violent offenders may trouble adjusting unexpected irrelevant stimuli may relate failures self regulation inhibitory control
effectiveness convolutional neural network cnn already demonstrated many challenging tasks computer vision image retrieval action recognition object classification paper specifically exploits cnn design local descriptors content based retrieval complete nearly complete three dimensional vessel replicas based vector quantization designed descriptors clustered form shape vocabulary object associated set clusters words vocabulary finally weighted vector counting occurrences every word computed reported experimental results pottery benchmark show superior performance proposed method spie
one promising fields ambient intelligence implementation intelligent emergency plans use drills living labs reproduce social behaviors panic attacks strongly affect plans use agent based social simulation provides approach evaluate plans thoroughly hypothesis presented paper little interest describing key modules simulators must include formally represented knowledge realistic simulated sensor model especially providing researchers tools reuse extend interconnect modules different works lack interest hinders researchers achieving holistic framework evaluating emergency plans forces reconsider implement components scratch addition supporting hypothesis considering simulators paper defines main modules identified proposes use semantic web technologies cornerstone aforementioned holistic framework provides basic methodology achieve framework identifies main challenges presents open free software tool hint potential holistic view emergency plan evaluation indoor environments
decision tree one techniques data mining prediction using method hidden information abundant data taken interpret information useful knowledge paper academic performance student examined two faculties faculty manufacturing engineering faculty microelectronic engineering university malaysia perlis unimap objectives study determine compare factors affect students academic achievement two faculties prediction results show five attributes considered factors influence students academic performance
terms policy ministry construction prepared issued guidelines green ecological residential area construction elements technical china ecological residential technology evaluation manual environmental impact evaluation law people republic china documents practice economically developed areas combined characteristics carried green building applications construction green ecological district vanke langrunyuan etc worth mentioning beijing green olympics shanghai eco expo made green building concept deeply rooted people hearts although green building aroused widespread attention among walks life green building still initial stage need standardize evaluation criteria research order make green building enter substantive application stage therefore study uses multi level gray evaluation method qualitative quantitative combining method evaluate green building basis research evaluation methods ecological residence foreign countries british breeam leed multinational gbtool chinese ecological residence absorb essence abandon defects establishment green building evaluation ecological view study gray comprehensive evaluation indicator used evaluate green performance building better identify compare effectiveness green buildings allow easier promotion application across country
objective study explore outcomes preventive programs psychosocial treatments suicidal ideation behaviour gender sub groups mixed gender studies studies limited one gender method used systematic review randomized controlled trials rcts included women men reported examined outcomes psychosocial interventions mixed gender samples total rcts reported examined differences intervention outcomes mixed gender rcts reported greater effectiveness females males review identified promising interventions female samples none trials reported greater effectiveness intervention men majority reviewed studies looking treatment outcomes gender sub groups showed differences women men indicated psychosocial interventions effective women need studies look gender effects development interventions effective appealing men risk suicide
small modular reactor smr offers many feasible pathways construction nuclear power plants physics model near term deployable smr integral pressurized water reactor ipwr design developed fuel depletion simulations performed optimize active fuel length fuel enrichment core loading pattern order achieve uniform core power distribution optimized core produce thermal power four year core life time capacity factor core consists uranium dioxide fuel assemblies assemblies enrichment assemblies enrichment active fuel length core diameter active core height diameter ratio part study active fuel length increased resulting increased capacity factor thermal power output active core height diameter ratio rod cluster control assemblies rccas placed strategically reduce overall core power peaking factor estimated reactor kinetics parameters delayed neutron fraction mean neutron generation time typical existing larger pressurized water reactors pwrs much ipwr based smr design derived study showed doppler moderator temperature void power reactivity coefficients negative core life time four years indicating possibility safe reactor operation semi analytical thermal hydraulics analysis reveals acceptable radial axial fuel element temperature profiles significant safety margin industry standards peak fuel clad surface temperature limits critical heat flux chf calculated exceeded even overpower conditions addition nucleate boiling ratio dnbr calculated found entirety active core region parameters engender confidence safety smr design elsevier ltd rights reserved
background although fishing communities significantly higher hiv prevalence general population paucity data burden hiv service utilization particularly among youth assessed hiv prevalence utilization hiv prevention treatment services among youth kasensero fishing community neighboring communities method data derived rakai community cohort study rccs surveys conducted rccs population based household survey collects data annually individuals aged years resident communities rakai neighboring districts uganda analysis socio demographic behavioral hiv related data obtained individuals aged years used logistic regression conduct bivariate multivariable analysis determine factors independently associated hiv positive status corresponding confidence intervals data analyzed using stata version results overall hiv prevalence higher kasensero gwanda kyebe among females males uptake hiv testing high hiv positive hiv negative youth consistent condom use virtually non existent hiv positive youth compared hiv negative youth hiv positive youth receiving antiretroviral therapy art higher hiv positive females hiv positive males slightly half males reported circumcised proportion circumcised youth higher among hiv negative males hiv positive males factors significantly associated hiv positive status included living kasensero landing site adjusted odds ratio aor reporting one aor sexual partners past months aor conclusion prevalence hiv high especially among young females landing site communities peripheral communities uptake hiv prevention treatment services low urgent need youth friendly services communities
quest observe gravitational waves challenges ability discriminate signals detector noise issue especially relevant transient gravitational waves searches robust eyes wide open approach called sky burst searches show signal classification methods inspired broad astrophysical characteristics implemented sky burst searches preserving generality case study apply multivariate analyses based artificial neural networks classify waves emitted compact binary coalescences enhance orders magnitude significance signals belonging broad astrophysical class noise background alternatively given level mis classification noise events detect total signal population also show general strategy signal classification actually performed testing ability artificial neural networks discriminating different signal classes possible impact future observations ligo virgo network detectors discussed analysing recoloured noise previous ligo virgo data coherent waveburst one flagship pipelines dedicated sky searches transient gravitational waves
biological clocks genetically encoded oscillators allow organisms keep track environment among circadian system highly conserved timing structure regulates several physiological metabolic behavioural functions periods close time also crucial everyday activities involve conscious time estimation timing behaviour second minutes range known interval timing involves interaction cortico striatal circuits review summarize current findings neurobiological basis circadian system genetic behavioural level also focus interactions interval timing seasonal rhythms order construct multi level biological clock
hepatocellular carcinoma hcc prevalent primary liver cancer incidence rise largely attributed hepatitis virus hcv related liver cancer distinct feature hcv associated hcc substantially increased incidence metastasis compared non viral hbv associated hcc first reported human metastasis suppressor regulated many human metastatic cancers functions modulated several virus associated cancers study shows hcv protein expression well hcv infection induces pro metastatic effect cancer cells simultaneous transcriptional regulation protein degradation moreover intracellular localization significantly altered cells expressing hcv protein importantly overexpression rescue cancer cells pro metastatic effects hcv hcv infection limited study provides evidence role hcv mediated cancer metastasis
objectives explore impact lushan earthquake schoolchildren health learning environment months earthquake collect children health information identify school environmental health risks methods explorative single case study case defined two primary schools affected earthquake april relocated rebuilt temporary classroom study collaborated department social work sichuan agricultural university located support social work station school age children affected majun gonghe primary schools invited participate study july finally children participated data collected structured questionnaire field observation social work station report analyzed using descriptive analysis qualitative content analysis results one hundred eighty seven school age children participated study participants demographic characteristics showed around half subjects male majority aged grades whereas preschool children near three quarters children living parents school environmental health risks identified including public health school building risks conclusions one hundred eighty seven school age children two primary schools involved study baseline data children health status obtained school health risks identified findings suggested would vital develop collaborative care service learning model enhance children health school safety disaster prone community
point view power engineering successful commercial market electric vehicles demands completely new concept integration contemporary electrical network electric vehicles limited range charged short periods means grid problems peaks daily load profile paper outlined one promising decentralization network help multiagent systems agent collects evaluates data vehicles small area manages area relative independently main problem create algorithm optimal cooperation communication agents example cooperation shown firstly simple linear programming problem secondly complex using game theory mathematical basis multiagent systems system connected smart grid possibilities altering load profile shown last chapter explores necessity shift grid artificial intelligence epistemic modal logic presented possible solution
purpose clarify mechanism inhibitory action trk naltalimide unique opioid receptor partial agonist micturition reflex methods effect trk isovolumetric rhythmic bladder contractions rbcs examined guinea pigs effect clarified treatment naloxone spinal cord transection effect trk urodynamic parameters also observed guinea pigs addition effect trk bladder contraction induced peripheral stimulation pelvic nerve investigated rats results trk dose dependently inhibited rbcs dose dependently antagonized naloxone however antagonism susceptibility different morphine minimum effective dose trk remained similar spinal cord transected animals trk increased bladder capacity without changing voiding efficiency maximum flow rate intravesical pressure maximum flow rate whereas oxybutynin increased bladder capacity affected parameters trk produce significant changes bladder contractions induced peripheral stimulation pelvic nerve oxybutynin significantly suppressed bladder contractions conclusions results suggest trk enhances bladder storage function modulating afferent limb micturition reflex opioid receptors spinal cord trk could effective safer therapeutic agent different fashion antimuscarinics conventional opioids overactive bladder
stable highly crystalline titanium dioxide colloids paramount importance establishment solution processable library materials could help bringing advantages digital printing world photocatalysis solar energy conversion nano sized titanium dioxide anatase phase synthesized means hydrothermal methods treated hydrogen peroxide form peroxy titanium complexes ptcs influence hydrogen peroxide structural optical rheological properties titanium dioxide colloidal solutions assessed practical demonstration low temperature compliant digitally printed anatase thin film given elsevier inc rights reserved
tumors develop resistance targeted cancer drugs even though drugs produced substantial clinical responses established anaplastic lymphoma kinase alk positive drug resistant lung cancer cell lines resistant ceritinib ldk found ceritinib treatment resulted robust upregulation src activity measured phosphorylation src substrate paxillin knockdown src alone sirna effectively sensitized ceritinib resistance alk positive cells furthermore src inhibition azd effective alk resistant cancer cells thus alk inhibition ceritinib may lead upregulation src signaling azd could serve potential drug clinic treat alk resistant lung cancer patients
major depressive disorder mdd severe mental illness leading long term disabilities one current challenges psychiatric research develop new approaches investigate pathophysiology mdd monitor drug response order provide better therapeutic strategies patients since retina considered part central nervous system suggested constitutes appropriate site investigate mental illnesses past years several teams assessed retinal function patients mood disorders many relevant abnormalities reported investigation retinal electrophysiological abnormalities mdd remains young emerging field believe current findings promising argue objective retinal electrophysiological measurements may eventually become relevant tools investigate pathophysiology mdd review retinal abnormalities detected objective electrophysiological measurements flash electroretinogram ferg pattern electroretinogram perg electrooculogram eog patients mdd discuss changes might reflect pathophysiology mdd clinical scientific points view according especially monoamine neurotransmission deficiency hypothesis also discuss technical details must taken consideration potential use objective retinal electrophysiological measurements tools investigate pathophysiology mdd elsevier ltd rights reserved
study presents results rheological measurement clay suspensions using vane geometry wide gap configuration focuses measurement viscosity effective two reasons limits vane geometry limits material depending content solid particles image analysis flow shearing material carried relate flow behavior several approaches compute shear flow curve torque rotational velocity data used results demonstrate applied setpoint applying logarithmic shear rate ramp different calculated shear rate existing theories depending solid volume fraction particles mixture relate macroscopic behavior using image analysis shear flow curves rheophysical regime flow suspensions therefore paper two simultaneous goals first one describe physical phenomena control macroscopic behavior second one highlight limits vane geometry viscosity measurement mineral suspensions like kaolinite pastes
deceleration processor scaling due moore law accelerates research new types computing structures need arises rethinking operating systems paradigms traditionally operating system layer hardware applications primary function managing hardware resources providing common abstraction applications function apply however new types computing paradigms operating systems even needed new structures paper revisits operating system functionality new computing paradigms structure new computers uncertain many possibilities neuromorphic bio inspired adiabatic reversible approximate quantum combinations others unforeseen know however whatever new computers need manage resources provide programming support partition scale connect deal partial failure along traditional operating system functionality might also new functionality creating abstract control loops reasoning precision new ways reconfiguring strongly believe even traditional operating systems functionality evolves need operating systems remain new era computing
paper presents load control method small data centers rarely studied although account data centers method utilizes data network electrical network control power usage participation demand response programs regarded killer applications emerging smart grid traditional data center power management often directly manipulates energy usage may ineffective impractical small data centers due limited resources data centers considered cyber physical systems cpss article proposes approach performs data center load management cyberspaces targeted data center proposed method instructs workload dispatcher select best suited algorithm event issued additionally method also adjusts temperature set points air conditioners simulation result shows approach achieve power reduction elsevier rights reserved
golimumab glm latest anti tumor necrosis factor tnf gained marketing license thanks pursuit induction maintenance trials approved treatment ulcerative colitis anti tnf drugs available infliximab adalimumab two drugs validated algorithms concerning prescription therapeutic drug monitoring tdm little known glm available data glm exposure response relationship pursuit trials recently published data reveal factors may impact pharmacokinetic parameters dosage body weight concomitant drugs presence anti drug antibodies adabs sex age addition glm trough level steady state appears correlated patient improvement may make precious indicator predict clinical response however consensus possible therapeutic level cutoff associated clinical response remission outcome measure endoscopic healing lack threshold value validation different assay techniques makes difficult use glm tdm clinical practice anti tnf agents glm associated development adabs prevalence effects still insufficiently described objective review describe current data understanding glm including serum concentrations glm adabs patients better understanding parameters could lead improved patient care glm
real time image filtering technique proposed could result faster implementation fingerprint image enhancement one major hurdle associated fingerprint filtering techniques expensive nature hardware implementations circumvent modified anisotropic gaussian filter efficiently adopted hardware decomposing filter two orthogonal gaussians oriented line gaussian architecture developed dynamically controlling orientation line gaussian filter improve performance filter input image homogenized local image normalization proposed structure middle range reconfigurable fpga parallel compute intensive real time demands achieved manage efficiently speed image processing time improve resource utilization fpga test results show improved speed hardware architecture maintaining reasonable enhancement benchmarks
background syntax synergy percutaneous coronary intervention taxus cardiac surgery trial patients vessel left main coronary artery disease cad improved long term outcomes coronary artery bypass graft cabg surgery compared percutaneous coronary intervention pci drug eluting stents des improvements driven mainly differences myocardial infarction repeat revascularization objectives study compared long term quality life benefits des pci versus cabg patients vessel left main cad methods syntax trial randomized patients vessel left main cad either cabg des pci health status assessed baseline months using seattle angina questionnaire saq item short form health survey results year follow cabg superior des pci several saq domains including angina frequency physical function well role physical role emotional scales item short form health survey subgroup analysis demonstrated significant interaction angiographic complexity assessed syntax score angina relief mean difference saq angina frequency score cabg pci points low intermediate high syntax score patients respectively interaction conclusions among patients vessel left main cad cabg des pci associated substantial sustained quality life benefits years follow general cabg resulted greater angina relief although absolute treatment benefit small angina relief years enhanced cabg among patients high syntax scores finding reinforcing recommendation cabg strongly preferred patients synergy percutaneous coronary intervention taxus cardiac surgery syntax nct american college cardiology foundation
background programmed cell death protein plays important role immune response regulation inhibitory signal cell activation however little known serum autoantibody profile systemic lupus erythematosus sle disease characterized breakdown immune tolerance self antigens excessive production autoantibodies thus aim investigate serum levels function anti patients new onset sle methods serum levels anti igg igm isotypes detected new onset sle patients rheumatoid arthritis primary sjogren syndrome ankylosing spondylitis healthy controls using enzyme linked immunosorbent assay elisa correlation anti clinical characteristics laboratory parameters patients new onset sle analyzed effects purified anti igg sle patients cell proliferation measured using flow cytometry results data revealed increased levels anti igg igm especially new onset sle patients positive rate anti igg level anti igg closely associated malar rash arthritis serositis hematological renal neurological involvement moreover serum levels anti igg positively correlated sle disease activity index sledai score erythrocyte sedimentation rate esr vitro examination showed purified anti igg obtained sle patients enhanced cell proliferation cultured dendritic cells dcs conclusions current study indicates first time serum levels inhibitor autoantibodies elevated new onset sle patients associated disease activity sle autoantibodies facilitating cell proliferation revealed new insight function negative regulation signals involved pathogenesis sle
long literature demography debated importance place health especially children health study assess whether importance dense settlement infant mortality child height moderated exposure local sanitation behavior open defecation without toilet latrine worse infant mortality child height population density greater poor sanitation important mechanism population density influences child health outcomes present two complementary analyses using newly assembled data sets represent two points trade external internal validity first concentrate external validity studying infant mortality child height large international child level data set demographic health surveys matched census population density data subnational regions second concentrate internal validity studying child height bangladeshi districts using new data set constructed gis techniques allows control fixed effects high level geographic resolution find statistically robust quantitatively comparable interaction sanitation population density approaches open defecation externalities important child health outcomes people live closely together
disruptive mood dysregulation disorder dmdd included first time revision dsm transatlantic controversy surrounding clinical picture prevalence early onset bipolar disorder gave occasion develop new diagnostic category chapter depressive disorders capturing behavioral phenotype non episodic chronic irritability frequent temper tantrums present paper reviews first available studies applying new criteria dmdd clearly distinguished bipolar disorder preliminary evidence suggests strong overlap oppositional defi ant disorders odd upcoming revision icd discussed introduce specifier indicating whether presentation odd includes chronic irritability anger rather establishing new diagnosis regardless nosological categorization described behavioral phenotype main challenges represent better understanding regard etiology developmental psychopathology prognosis development beneficial treatment options
discovering new effective antibiotics major issue facing scientists today luckily development computer science offers new methods overcome issue study set computer software used predict antibacterial activity nonantibiotic food drug administration fda approved drugs explain action possible binding well known bacterial protein targets along testing antibacterial activity gram positive gram negative bacteria three dimensional virtual screening method relies chemical shape similarity applied using rapid overlay chemical structures rocs software select candidate compounds fda approved drugs database share similarity known antibiotics check antibacterial activity disk diffusion test applied staphylococcus aureus escherichia coli finally protein docking method applied using hybrid software predict binding active candidate target receptor similar antibiotic drugs screened selected among drugs showed antibacterial activity whereby drotaverine metoclopramide activities without precedent reports furthermore docking process predicted diclofenac drotaverine flurbiprofen ibuprofen indomethacin could bind protein target similar antibiotics nevertheless antibacterial activities weak compared similar antibiotics potentiated performing chemical modifications structure
characterizing plant responses past present future changes atmospheric carbon dioxide concentration critical understanding predicting consequences global change evolutionary ecological timescales previous studies provided great insights effects rising leaf level gas exchange carbohydrate dynamics plant growth however scaling effects across biological levels especially field settings proved challenging moreover many questions remain fundamental molecular mechanisms driving plant responses global change factors discuss three examples topics significant questions research remain unresolved mechanisms effects plant developmental transitions implications rising integrated plant water dynamics drought tolerance effects symbiotic interactions eco evolutionary feedbacks addressing key questions research require collaborations across scientific disciplines new approaches link molecular mechanisms complex physiological ecological interactions across spatiotemporal scales
teachers need continuously update information communication technologies ict knowledge usually trained deal problems arising use fact studies literature report techno anxiety unpleasant physiological activation discomfort due present future use ict teachers thus goal action research study teachers techno anxiety reduced increasing ability solve technological problems inter subject experiment carried teachers high school teachers chosen digital immigrants moment research students digital natives born around year since could find specific training teachers increase resolution skills technological problems order apply treatment study designed deployed online course ict problem solving skills based model learning development results show success course comes increasing ict problem solving skills reducing techno anxiety
paper discusses compares different abstract state space representations class linear hyperbolic systems defined one dimensional spatial domain starts pde representation weakly strongly coupled forms next homogeneous state equation including unbounded formal state operator presented based semigroup approach results well posedness internal stability given boundary observation operators introduced assuming typical configuration boundary inputs well pointwise observations state variables consequently homogeneous state equation extended called boundary control state signal form next classical additive state space representation involving triple state input output operators considered short discussion appropriate hilbert spaces state space equation called factor form also presented finally resolvent system state operator discussed
background psoriasis debilitating chronic inflammatory autoimmune disease affecting approximately million adults united states plaque psoriasis common form affecting patients objectives describe impact challenges psoriasis presents various stakeholders provide nondermatologist healthcare decision makers information enhance contributions drug pharmacy benefit design discussions discussion psoriasis carries increased risk early mortality increased prevalence comorbidities including psoriatic arthritis cardiovascular disease diabetes also associated anxiety depression social isolation negatively impact patients relationships productivity careers physical psychologic social economic impact psoriasis plus associated stigma result cumulative impairment patient lifetime current treatments moderate severe psoriasis include topical therapy phototherapy systemic drugs nonbiologic biologic however patient satisfaction remains low combination therapy treatment switching common many patients remain untreated undertreated clinicians consider patient holistically select treatment based range factors including disease severity physical psychosocial manifestations susceptibility cumulative life course impairment considering personality behavior cognition comorbidities concomitant medication patient preference estimated total annual direct cost treating psoriasis united states exceeded billion conclusion psoriasis complex disease appropriate management correspondingly complex newer psoriasis treatments provide improved efficacy safety versus traditional treatments challenges remain ensuring patients access medications improved understanding barriers appropriate treatment needed well clear accessible information payers clinicians current treatment options ensure decision makers control costs providing patients optimal care
nonlinear time series analysis applied first time time series obtained large eddy simulations les internal combustion engine ice aim study obtain information cycle cycle variation ccv studied simplified ice geometry available standard methods phase space reconstructions created time series estimates largest lyapunov exponent calculated time delays used phase space reconstructions determined using average mutual information proper embedding dimensions chosen according method false nearest neighbours quantitative information behaviour flow ccv acquired three dimensional phase space reconstructions introduced modifications flow clearly visible phase space reconstructions energy dissipation indicating quantities appropriate monitoring analysing state system estimates largest lyapunov exponents positive almost time series indicating chaotic dynamics permutation spectrum test used confirm chaoticity ccv present results indicate used methods offer promising new framework characterising ccv viewpoint nonlinear time series analysis elsevier inc rights reserved
background hepatosplenic schistosomiasis hes evaluated transient elastography far correlation ultrasound variables remains defined aims aim study describe parameters liver spleen stiffness hes assessed transient elastography comparison cirrhotics controls evaluating correlation ultrasonographic data patients methods hes hepatitis virus cirrhotic control patients included sectional study liver spleen stiffness compared among three groups ultrasonographic parameters compared transient elastography hes patients results thirty hes hepatitis virus cirrhotic patients controls included hes presented liver stiffness significantly higher controls lower cirrhotics versus versus kpa spleen stiffness values comparable hepatosplenic cirrhotics versus kpa significantly higher controls kpa patients hes high spleen stiffness associated right liver lobe diameter splenic artery resistance index portal vein diameter portal vein area portal vein congestion index splenic vein diameter spleen diameter conclusion liver stiffness may useful tool differentiate portal hypertension related cirrhosis hes high spleen stiffness potential surrogate marker portal hypertension population copyright wolters kluwer health inc rights reserved
performance thick high density polyethylene geomembrane gmb simulated municipal solid waste landfill liners presented accelerated ageing experiments conducted geosynthetic liner longevity simulators allow simulation field conditions including elevated temperatures overburden pressure leachate circulation composite liner exposure conditions sand protection layer used gravel drainage layer underlying gmb liner comparison results obtained sand protection layer obtained geotextile protection layer presented terms antioxidant depletion tensile strains antioxidant depletion stage gmb sand protection layer predicted around years degrees degrees respectively antioxidant depletion stage sand protection layer longer geotextile protection factor gmb leachate test boundary conditions comparison tensile strains induced gmb sand geotextile protection layers shows long term tensile strains gmb sand protection layer substantially lower gmb geotextile protection layer
aim paper show well known sparskit spmv routines ellpack itpack jagged diagonal formats easily successfully adapted hybrid gpu accelerated computer environment using openacc formulate general guidelines simple steps done transform source codes irregular data access efficient openacc programs also advise improve performance programs tuning data structures utilize hardware properties gpus numerical experiments show accelerated versions sparskit spmv routines achieve performance comparable performance corresponding cusparse routines optimized nvidia
study proposes new design generalized predictive control multirate system sampling interval plant output integer multiple hold interval control input design system one degree freedom integral action extend two degrees freedom integral compensation revealed modeling error disturbance arises integral compensation cause transient response deteriorate absent moreover even modeling error step type disturbance plant output converges step type reference input integral compensation revealed proposed design based state space representation hence easily extended multivariate system
setting multicentred hospital based cases control subjects korea objective evaluate association idiopathic pulmonary fibrosis ipf hazardous materials people occupationally exposed design multicentre hospital based matched case control study performed ratio ipf cases controls group ipf cases controls matched terms age group sex place residence conditional logistic regression analysis performed results simple logistic regression analysis exposure metal dust exposure year occupational setting significantly associated ipf metal dust exposure adjustment environmental military exposures smoking history metal dust exposure multiple logistic regression analysis conclusions metal dust associated incident ipf seoul gyeonggi provinces korea information used support tailored preventive strategy specific industries occupations
objectives angioedema potentially life threatening occurrence encountered critical care providers mechanistic understanding angioedema syndromes improved recent years novel medications available improve outcomes syndromes clinically focused review describe underlying genetics pathophysiology classification treatment angioedema syndromes emphasis novel pharmacologic agents recently become available acute treatment data sources medline search conducted mesh terms angioedema acquired angioedema hereditary angioedema type iii angiotensin converting enzyme inhibitor induced angioedema study selection selected publications describing angioedema clinical trials diagnosis management genetics retrieved reviews guidelines clinical trials case series bibliographies also reviewed identify relevant publications data extraction data relevant publications reviewed summarized information synthesized data synthesis data obtained used describe current state diagnosis management various angioedema syndromes conclusions angioedema life threatening syndrome multiple subtypes distinct pathophysiology present evidence based approach diagnosis suggested management various subtypes angioedema securing airway remains important intervention followed administration established novel pharmacologic interventions based disease pathology crit care med
introduction opportunistic pneumonias major cause mortality morbidity human immunodeficiency virus hiv reactive patients despite significant role fungi play causation opportunistic mycoses indian studies attempted investigate burden aetiological spectrum hiv aids associated fungal pneumonias aim document prevalence fungal aetiology hiv aids related opportunistic pneumonias indian setting elucidate various fungal opportunists responsible materials methods present study prospective cross sectional analysis conducted maulana azad medical college associated lok nayak hospital new delhi october september expectorated sputa collected hiv reactive patients clinical diagnosis pneumonia subjected direct microscopic examination employing gram stain koh wet mount india ink preparation addition direct immunofluorescence sputum samples performed detection cysts trophozoites pneumocystis carinii also sputum sample inoculated duplicate onto sabouraud dextrose agar sda culture blood sample drawn patient battery serological tests performed including cryptococcal antigen latex agglutination system calastm detection cryptococcal capsular polysaccharide antigen platelia aspergillus eia detection aspergillus galactomannan antigen serion elisa antigen candida detection candida antigen histoplasma dxselect detecting antibodies histoplasma species descriptive statistics employed depict results proportions figures arithmetic mean standard deviation calculated central tendencies median non normal skewed distributions results definite fungal aetiology established hiv reactive patients pneumonic involvement sputa patients yielded single fungal isolates mixed fungal isolates reported four patients pneumocystis carinii predominant fungal pathogen isolated study reported patients pulmonary aspergillosis reported patients aspergillus flavus aspergillus fumigatus aspergillus niger commonly recovered aspergillus species candida pneumonia documented patients candida species isolated included candida albicans four candida glabrata one candida tropicalis one six patients respectively pulmonary cryptococcosis diagnosed patients coexisting cryptococcal meningitis documented one furthermore antibodies histoplasma species detected cases suggesting possible aetiological role conclusion fungal opportunistic pneumonias common hiv reactive patients indian setting warrant prompt accurate diagnostic evaluation form combination microbiological serological histopathological techniques effective prophylactic therapeutic management
background opioid use disorder oud affects approximately million people worldwide study aims determine association age onset opioid use comorbid disorders physical psychiatric patients receiving methadone maintenance treatment mmt oud understanding association may inform clinical practice important prognostic factors patients mmt enabling clinicians identify high risk patients methods study includes data collected june august genetics opioid addiction research collaborative mcmaster university canadian addiction treatment centers patients interviewed trained health professionals using mini international neuropsychiatric interview case report forms physical comorbidities verified using patients electronic medical records multi variable logistic regression model constructed determine strength association age onset opioid use presence physical psychiatric comorbidity adjusting current age sex body mass index methadone dose smoking status results data mmt patients mean age years analyzed individuals age onset opioid use younger years found higher odds physical psychiatric comorbid disorder compared individuals age onset opioid use years older odds ratio confidence interval significant association found risk comorbidity age onset opioid use years years compared age onset opioid use years older conclusion study demonstrates younger one begins use opioids greater chance physical psychiatric morbidity understanding risk posed earlier onset opioid use later development comorbid disorders informs clinical practice important prognostic predictors aids identification high risk patients
proportional integral derivative pid controller design based gaussian process model proposed study model defined mean covariance function provides predictive variance addition predicted mean model highlights areas prediction quality poor due lack data indicating higher variance around predicted mean variance information taken account pid controller design used selection data improve model successive stage results trade safety performance due controller avoiding region large variance cost tracking set point ensure process safety proposed direct method evaluates pid controller design gradient calculation order reduce computation characteristic instantaneous linearized model extracted linearized framework pid controller design two case studies continuous batch processes carried illustrate applicability proposed method elsevier ltd rights reserved
smart environments interactive spaces offer quality life users considering definition study aims investigate papers containing projects evaluation smart environments context smart cities using gesture based interaction applied health solutions approach systematic review literature examined following databases ieee xplore sciencedirect springer citeseerx google scholar november december studies identified agreement eligibility criteria analysis papers usability smart gesture based environments discussed considering medical area presenting possible benefits healthcare
among various nanofillers composite systems carbon based fillers graphite carbon fibers carbon black carbon nanotubes graphene etc attracting great attention academia industry advent highly integrated electronic devices objective fabricating composite materials obtain distinct properties evolved synergistic effects component materials may exploited various applications electronics optical devices present work polyurethane graphite composites synthesized aim using electromagnetic shielding applications polyurethane graphite composites prepared situ polymerization method presence graphite nanoparticles prepared composites characterized scanning electron microscope transmission electron microscope tem ray diffraction techniques shifting major peak graphite nanoplatelets gnps prepared nanocomposites towards left degrees spacing degrees spacing theta scale indicates intercalation type dispersion prepared nanocomposites validated tem characterization introduction gnps polyurethane situ polymerization creates electrical network resulting composite therefore makes highly conductive prepared nanocomposite showed electrical network vol percolation threshold condition similar percolation threshold found conditions maximum conductivity found vol filler loading resulting composites evaluated electromagnetic interference emi shielding different filler loadings prepared gnps composites found highly effective shielding effectiveness electromagnetic interference shielding materials ghz
sexual gender minority sgm youth often live nonsupportive environments study reports influence social support primary secondary social ties confidence self esteem among participants hatch youth drop group level intervention sgm youth hour hatch youth meeting consists social educational youth led support hour weeks meetings randomly observed individual interviews participating youth staff volunteers conducted data underwent content analysis participants perceived increase confidence self esteem enhanced bonding family friends sense belonging community empowerment involvement hatch youth suggesting drop centers strengthen secondary social ties improve confidence self esteem
methyladenosine prevalent modification present mrnas higher eukaryotes yth domain family ythdf reader protein recognize mrna sites mediate mrna degradation however regulatory mechanism ythdf poorly understood end investigated post transcriptional regulation ythdf bioinformatics analysis suggested microrna mir might target untranslated region utr ythdf mrna levels mir negatively correlated ythdf mrna clinical hepatocellular carcinoma hcc tissues immunohistochemical staining revealed ythdf closely associated malignancy hcc interestingly mir decreased luciferase activities utr ythdf mrna mutation predicted mir binding sites utr ythdf mrna abolished mir induced decrease luciferase activity overexpression mir dose dependently regulated ythdf expression hcc cells levels mrna protein conversely inhibition mir resulted regulation ythdf cells dot blot analysis immunofluorescence staining revealed overexpression mir strongly increased levels relative control hcc cells increase could blocked ythdf overexpression moreover mir inhibition strongly decreased levels rescued treatment small interfering rna based ythdf knockdown thus conclude mir modulates levels targeting utr ythdf mrna hcc cells
long section expressway polish villages paslek milomlyn completed road alignment partially crossed thick organic soil formations showing consistency range plastic soft plastic therefore subsoil improvement measures unreinforced full displacement concrete piles geotextile reinforced embankment designed owner despite executed soil improvement measures seven months release traffic settlements occurred along long section expressway utilizing finite element method well comparative calculations using conventional methods failure back analysis conducted zentrale technik technical office vienna article hand focusses executed assessment damage well results performed failure analyses furthermore elaborated restoring concepts restoring measure executed site presented
hemibiotrophic fungal pathogen leptosphaeria maculans causal agent blackleg disease brassica napus canola oilseed rape causes significant loss yield worldwide genetic resistance used mitigate disease means traditional breeding strategies little knowledge genes contribute blackleg resistance rna sequencing streamlined bioinformatics pipeline identified unique genes plant defense pathways specific plant resistance napus maculans lepr avrlepr interaction time complemented temporal analyses monitoring gene activity directly infection site using laser microdissection coupled quantitative pcr finally characterized genes involved plant resistance blackleg arabidopsis maculans model pathosystem data reveal accelerated activation plant transcriptome resistant host cotyledons associated transcripts coding extracellular receptors phytohormone signaling molecules functional characterization provides direct support transcriptome data positively identifies resistance regulators brassicaceae spatial gradients gene activity identified response maculans proximal site infection dataset provides unprecedented spatial temporal resolution genes required blackleg resistance serves valuable resource interested host pathogen interactions
classic research initiated response heavy reliance children evidence certain types criminal cases showed incidence false memories declines steadily childhood young adulthood developmental decline pattern became centerpiece much expert testimony treated settled science court rulings settled science large number studies recently appeared developmental reversals opposite pattern false memories events preserve gist experience increase dramatically early childhood young adulthood developmental reversals challenge forensic principle children evidence inherently infected false memories adults evidence
introduction low birth weight associated increased risk heart disease high blood pressure diabetes adult life fetal growth determined nutrient availability related placenta nutrient transport medium chain fatty acids mcfas particular class nutrients known readily available energy source data reported mcfas low birth weight fetus aim prospective study conducted tertiary center prenatal diagnosis investigate maternal fetal mcfas levels appropriate gestational age aga intrauterine growth restricted iugr small gestational age sga pregnancies method plasmatic levels mcfas aga iugr sga mother infant pairs quantified gas chromatography mass spectrometry analytical method linearity range limit quantification reduced fetal growth defined estimated fetal weight percentile gestational age iugr without sga fetal doppler abnormalities result maternal fetal mcfas plasma levels significantly different among sga iugr aga groups additionally observed mcfas fetal maternal ratio iugr group whilst sga aga fetal maternal ratio less one conclusion changes mcfas levels fetal maternal plasma related placental functionality nutrients availability suggesting presence novo biosynthesis
wikipedia become common frequently used tool information source students asked academic assignment aware circumstance also limitations quality existing articles relation manufacturing processes technologies systems project initiated aimed enhancing organising learning activities around creation improvement contents wikipedia present work describe particular experience two optional subjects design manufacture assembly plastics technology main objectives activity encourage understanding knowledge skills values closely bound active use open free information systems promote autonomous learning study depth subject contents active attitude give possibility work knowledge generated students remain line accessible people lecturer raise ability critical evaluating different information sources learn work cooperative collaborative contexts addition manufacturing engineering contents wikipedia significantly improved several remarkable created improved articles manufacturing domain based results project objectives fulfilled outcomes positive lecturers satisfied terms quantity quality contributions whose time devoted students fit adequately planned intended skills exercised furthermore works even awarded manufacturing engineering society prize regarding students agreed activity interesting would recommend future even think make contributions wikipedia
disseminated peritoneal leiomyomatosis dpl rare disorder characterized presence multifocal nodules tumors composed proliferating smooth muscle tissue spread throughout peritoneum estrogens progesterone considered main factors initiating formation disseminated leiomyomatosis disseminated peritoneal leiomyomatosis often asymptomatic acyclic vaginal bleeding pain lower abdomen associated leiomyomatous rebuilt uterus corpus disseminated peritoneal leiomyomatosis ambiguous presentation difficulty dpl diagnosis always accompanied scattered leiomyomas occur menopause cases dpl associated surgical procedures uterine fibroids especially use morcellator present case year old woman dpl underwent laparoscopic myomectomy laparoscopic supracervical hysterectomy final diagnosis dpl complete surgical treatment performed center patient free symptoms
obstructive sleep apnea osa common condition associated significant morbidity health care utilization determined validity algorithm derived administrative data identifying osa using respiratory disturbance index rdi reference standard conducted retrospective cohort study adults alberta canada referred facility community based sleep diagnostic testing july august validity indices estimated several case definitions osa derived outpatient physician billing claims hospital discharge codes algorithm sensitivity specificity positive predictive value ppv negative predictive value npv calculated several reference standards osa rdi rdi rdi patients included study algorithm requiring one hospital discharge code two outpatient billing claims identifying osa year period sensitivity specificity ppv npv reference standard rdi comorbidities included case definition specificity ppv reference standard rdi similar findings observed using rdi reference standard identify claims based algorithm identifies osa high degree specificity patients referred sleep diagnostic testing validated algorithm good ppv may useful identifying patients osa population studies within single payer health care system
time series categorical data widely studied research topic particularly available work bayesian analysis categorical time series processes objective filling gap present paper consider problem bayesian analysis including bayesian forecasting time series categorical data modelled pegram mixing operator applicable ordinal nominal data structures particular consider pegram operator based autoregressive process analysis real datasets infant sleep status analysed illustrations also illustrate bayesian forecasting accurate corresponding frequentist approach intend forecast large time gap ahead copyright john wiley sons ltd
aimit remains unclear functional connectivity may related specific cognitive domains neuropsychiatric disorders used simultaneous resting state functional magnetic resonance imaging rsfmri electroencephalography eeg recording patients schizophrenia evaluate within outside default mode network dmn methodsour study population included patients schizophrenia healthy control participants participants acquired rsfmri data simultaneously recorded eeg data using compatible amplifier analyzed rsfmri eeg data used conn toolbox calculate regions interest also performed group comparisons standardized low resolution electromagnetic tomography based intracortical lagged coherence eeg frequency band results within dmn measured rsfmri eeg significantly differ groups analysis rsfmri data showed right posterior inferior temporal gyrus medial prefrontal cortex stronger among patients schizophrenia compared control participants conclusionanalysis within dmn using rsfmri eeg data revealed significant differences patients schizophrenia control participants however rsfmri data revealed modulated medial prefrontal cortex right posterior inferior temporal gyrus patients schizophrenia compared control participants suggesting patients altered higher correlations across nodes within outside dmn studies using simultaneous rsfmri eeg required determine whether altered within dmn associated schizophrenia
cognitive flexibility traditionally considered frontal lobe function however converging evidence suggests involvement larger brain circuit includes cerebellum reciprocal pathways connecting cerebellum prefrontal cortex provide biological substrate cerebellum may modulate higher cognitive functions observed cognitive inflexibility cerebellar pathology occur psychiatric disorders autism schizophrenia addiction however degree cerebellum contributes distinct forms cognitive flexibility rule learning unknown tested lurcherwildtype aggregation chimeras lose cerebellar purkinje cells development touchscreen mediated attentional set shifting task assess contribution cerebellum higher lower order rule learning cognitive flexibility purkinje cells sole output cerebellar cortex ranged tested mice reversal learning extradimensional set shifting impaired mice purkinje cell loss cognitive deficits unrelated motor deficits ataxic mice acquisition simple visual discrimination attentional set unrelated purkinje cells positive relationship observed purkinje cells errors exemplars novel non relevant dimension introduced collectively data suggest cerebellum contributes higher order cognitive flexibility lower order cognitive flexibility attention novel stimuli acquisition higher lower order rules data indicate cerebellar pathology observed psychiatric disorders may underlie deficits involving cognitive flexibility attention novel stimuli
mechanisms chlorination pbo cdo zno cuo poly vinyl chloride pvc sodium chloride naci including reaction temperatures pathways products studied compared found pvc chloridize four oxides via different mechanisms producing corresponding chlorides heavy metal oxides pvc pbo pvc cdo chloridized gas solid reaction hcl direct chlorination pvc occurred degrees pvc zno pvc cuo initial temperatures weight loss degrees lower pvc decomposition relatively facile chlorination pbo compared oxides might reason volatile metals naci chlorination effect cdo zno cuo absence media found first time naci alone could convert pbo pbcl via liquid solid reaction temperature higher melting point naci degrees oxygen involved chlorination effect naci markedly weaker pvc since pvc naci important chlorine sources solid waste chlorination effects heavy metals ignored elsevier ltd rights reserved
chronic brain hypoperfusion cbh induces accumulation abnormal cellular proteins accompanied cognitive decline autophagic lysosomal system abnormal dementia whether cbh accounts autophagic lysosomal neuropathology remains unknown show cbh significantly increased number autophagic vacuoles avs high levels decreased sqstm cathepsin levels hippocampi rats following bilateral common carotid artery occlusion weeks studies showed microrna mira upregulated weeks compared sham group additionally lamp proteins downregulated mira overexpression upregulated mira inhibition unchanged binding site mutations mir masks indicating lamp target mira knockdown endogenous mira prevented reduction lamp protein expression well accumulation avs hippocampi rats overexpression mira induced knockdown mira reduced accumulation avs level cultured neonatal rat neurons results revealed cbh rats weeks could induce inefficient lysosomal clearance regulated mira mediated downregulation lamp protein expression findings provide insight novel molecular mechanism autophagy mirna level
objectivethe aim research explore transition pathways transition aged youth child adolescent mental health services perth western australia secondary aim identify factors impact upon transition process methodcases discharged seven child adolescent mental health community clinics perth metropolitan area june june transition age years age examined retrospectively two hundred forty five cases met selection criteria reviewed psychiatric services online information system resultsfour specific pathways referral acceptance adult mental health service identified referred referred immediate engagement referred delayed engagement referred engagement accepted principal discharge diagnosis length stay housing situation discharge found influence likelihood referral principal discharge diagnosis found influence successful acceptance adult mental health service conclusionsthe factors found influence transition pathways present study largely consistent findings findings present research assist clinicians make informed decisions discussing transition clients broadly findings used policy makers support formation maintenance transition protocols
relationships autism quotient systematizing empathizing selectivity explored assess whether selectivity implicated complex social skills assumed experimentally examined eighty participants aged trained simultaneous discrimination task tested extinction degree learned elements reinforced compound higher lower scorers demonstrated greater selectivity relationship selectivity results imply high scorers perform similarly individuals asd cognitive task selectivity may related complex social skills like empathy
experiencing past adversity traditionally linked negative life outcomes however emerging evidence suggests heterogeneity exists respect links adversity resilience adversity often enhancing cooperation face joint suffering authors present studies designed examine severity past adversity associated enduring propensity empathy mediated compassion whether resulting compassion directly turn linked behavior meant relieve suffering others using mturk laboratory based paradigms authors find increasing severity past adversity predicts increased empathy turn linked stable tendency feel compassion others need addition demonstrate resulting individual differences compassion appear engender behavioral responses meant assist others charitable giving helping stranger
backgroundarteriovenous malformations avms underlie many diverse neurological signs symptoms headaches common presentation significant impact quality life objectivethe authors investigated gamma knife stereotactic radiosurgery srs outcomes patients avms associated headaches methodsthis retrospective study analyzed patients avms underwent srs patient headache symptoms led avm diagnosis developed post hemorrhage avm information regarding headache characteristics obtained patient medical records follow using scripted clinical interview median imaging follow months clinical follow months median treatment volume srs median marginal dose resultsthe actuarial avm obliteration rate years years patients reported overall headache severity decreased headache frequency reduced headache reduction reported patients year years median time improvement months srs headache medication usage decreased patients permanent adverse radiation effects srs occurred patients obliteration complete annual risk hemorrhage srs per year conclusionalthough recall bias related retrospective analysis impact outcomes headache symptoms associated avms may potentially decreased eliminated subset patients treated gamma knife radiosurgery
aberrant angiogenesis vascular remodeling main features idiopathic pulmonary fibrosis kallistatin anti angiogenic peptide known effects endothelial cells study aimed demonstrate kallistatin beneficial effects bleomycin blm induced pulmonary fibrosis rat model inhibiting angiogenesis twenty five rats randomly divided five experimental groups saline negative control blm blm model group blm kallistatin kal blm kallistatin kal blm kallistatin kal fibrillar collagen quantified masson trichrome hematoxylin eosin staining transforming growth factor beta tgf beta smooth muscle actin alpha sma microvascular density mvd measured immunohistochemistry vascular endothelial growth factor vegf vascular endothelial growth factor receptor vegfr tumor necrosis factor alpha tnf alpha assayed western immunoblotting elisa daily administration kallistatin attenuated fibrosis blm induced pulmonary fibrosis shown histology inflammation blm induced pulmonary fibrosis kallistatin reduced number inflammatory cells infiltrating bronchoalveolar lavage fluid kallistatin also inhibited vegf expression phosphorylation vegfr flk vitro kallistatin blocked tube formation inhibiting flk gsk beta phosphorylation results demonstrated continuous administration kallistatin attenuated blm induced pulmonary fibrosis improved survival blm rats reducing pulmonary fibrosis achieved partial inhibition pulmonary inflammation angiogenesis
context authors reported nationally representative data number sport recreation injuries resulting emergency department visitation existing studies provided years data longitudinal nature objective use novel algorithmic approach determine visitation due resulting substantially larger longitudinal dataset design descriptive epidemiology study setting hospital patients participants national hospital ambulatory medical care survey stratified random sample survey hospital eds combined years unweighted patient visits determined main outcome measure custom algorithm classified visits based international classification diseases ninth revision clinical modification code pattern recognition narrative text sport recreation visits assessed age categorized according broad injury classifications additional quantification performed visits lower extremity knee specific injuries sample weights applied provide national annual estimates results annually visits resulted largest classification injury sprains strains males substantially related visits females versus patients years old lower extremity knee specific injury visits annually injury types males higher rate visitation however females greater odds visitation lower extremity knee specific injury respectively conclusions burden health system visits substantial males presented higher rate injury though females higher proportion lower extremity knee specific injury visitations longitudinal analysis population level data provides information target research specific subpopulations mitigate injury
carbon nanotubes cnts hollow interior space explored biomedical applications drug repository undesirable inactivation devise cnts smart material controlled release cargo molecules propose concept gold carbon nanobottles encapsulating cis diammineplatinum dichloride cisplatin cddp cnts covalently attached gold nanoparticles aunps open tips cnts via different cleavable linkages namely hydrazine ester disulfide containing linkages compared previous study cddp leaked cnts hours aunps found significantly decrease spontaneous release addition cddp release aunp capped cnts via disulfide linkage selectively enhanced twofolds reducing conditions namely dithiothreitol dtt mimic intracellular environment treated human colon adenocarcinoma cells hct cddp loaded gold carbon nanobottles examined cell viability using lactate dehydrogenase assay interestingly found nanobottles cleavable disulfide linkage exerted stronger cytotoxic effect hct compared normal human fetal lung fibroblast cells imr therefore infer nanobottles strategy inbuilt disulfide linkage could attain selective release payload highly reductive tumor tissues avoiding collateral damage normal tissues
two competing theories address influence foetal testosterone cerebral laterality one proposing exposure high foetal testosterone concentrations related atypical lateralisation geschwind galaburda hypothesis high foetal testosterone concentrations exaggerate typical lateralisation callosal hypothesis current study examined relationship cord testosterone concentrations cerebral laterality language spatial memory adulthood male participants high nmol low nmol cord testosterone levels invited take part study group cerebral laterality measured using functional transcranial doppler ultrasonography participants completed word generation visual short term memory tasks typical left lateralisation language common high testosterone group low testosterone group chi spatial memory laterality unrelated cord testosterone level findings indicate foetal testosterone exposure related language laterality direction supports callosal hypothesis elsevier rights reserved
coverage connectivity two important problems wireless sensor network paper focuses wireless sensor network communication radius high density sensor nodes deployed randomly two times smaller sensing radius put forward distributed coverage multi connected node deployment algorithm based grid simulation results show algorithm paper guaranteeing wireless sensor network coverage connectivity reduce number active state nodes effectively prolong wireless sensor network lifetime theoretical analysis results show article nodes deployment algorithm achieves multi connected
educating future engineers gain high proficiency computational thinking essential career prospects educators acquiring good understanding various learning motivation factors tools well inter relationships significant step forward achieving goal article describe exploratory data analytic investigation influences various learning motivation factors one another well effecting learning group science engineering students taking computer programming courses based algorithmic results highlight concrete ideas may direct impact improving existing learning system describe graphical visualization algorithmic results guide set priority focusing learning motivation factors first factors next achieving given education goal among new insights easily obtainable confirmatory based analyses
extracting underlying low dimensional space high dimensional signals often reside center numerous algorithms signal processing machine learning literature past decades moreover working incomplete large scale datasets recently commonplace diverse reasons called big data era currently living calls devising online subspace learning algorithms suitably handle incomplete data anticipated goal recursively estimate unknown subspace processing streaming data sequentially thus reducing computational complexity paper online variational bayes subspace learning algorithm partial observations presented account unawareness true rank subspace commonly met practice low rankness explicitly imposed sought subspace data matrix exploiting sparse bayesian learning principles sparsity simultaneously low rankness favored subspace matrix sophisticated hierarchical bayesian scheme adopted proposed algorithm thus adept dealing applications whereby underlying subspace may also sparse new subspace tracking scheme outperforms state art counterparts terms estimation accuracy variety experiments conducted simulated real data elsevier rights reserved
psoriasis chronic inflammatory skin disease profound effects patients health related quality life hrqol twenty nine patients plaque psoriasis history streptococcal associated psoriasis exacerbations randomly assigned tonsillectomy control groups followed months patients evaluated psoriasis disability index psoriasis life stress inventory psoriasis area severity index hrqol psoriasis related stress improved significantly tonsillectomy group compared control group respectively mean improvement hrqol mean improvement psoriasis induced stress clinical improvement correlated significantly improved hrqol psoriasis related stress tonsillectomized patients concluded procedure worthwhile tonsillectomy may improve quality life selected patients plaque psoriasis
drilling using twist drill frequently used secondary machining fiber reinforced composite laminates delamination important concern drilling drill design drilling parameters associated thrust distribution drilling induced delamination presented core center drill found advantageous core drill reference practice experiences response surface methodology rsm practical economical useful tool modeling analysis experimental results using polynomials local approximations true input output relationship due radial basis function network rbfn fast learning speed simple structure local tuning global generalization power researchers field manufacturing engineering using rbfn nonlinear manufacturing studies present paper compares two techniques using various drilling parameters diameter ratio feed rate spindle speed predict thrust force core center drill drilling composite materials obtained results indicated rbfn practical effective way evaluation drilling induced thrust force
mesenchymal stem cell msc applied therapy allergic disorders due beneficial immunomodulatory abilities however underlying mechanisms therapeutic efficacy reported diverse according source cell isolation route administration sought investigate safety efficacy human adipose tissue derived mscs hat mscs mouse atopic dermatitis model determine distribution cells intravenous administration murine model established multiple treatment dermatophagoides farinae mice intravenously infused hat mscs monitored clinical symptoms administration hat mscs reduced gross histological signatures well serum ige level hat mscs mostly detected lung heart mice within days administration hardly detectable weeks mice administered hat mscs survived sacrifice demonstrate adverse events culture experiments revealed hat mscs significantly inhibited proliferation maturation lymphocytes via cyclooxygenase cox signaling moreover mast cell degranulation suppressed hat msc conclusion intravenous infusion hat mscs alleviate regulation cell function mesenchymal stem cell msc applied therapy allergic disorders due beneficial immunomodulatory abilities however underlying mechanisms therapeutic efficacy reported diverse according source cell isolation route administration sought investigate safety efficacy human adipose tissue derived mscs hat mscs mouse atopic dermatitis model determine distribution cells intravenous administration murine model established multiple treatment dermatophagoides farinae mice intravenously infused hat mscs monitored clinical symptoms administration hat mscs reduced gross histological signatures well serum ige level hat mscs mostly detected lung heart mice within days administration hardly detectable weeks mice administered hat mscs survived sacrifice demonstrate adverse events culture experiments revealed hat mscs significantly inhibited proliferation maturation lymphocytes via cyclooxygenase cox signaling moreover mast cell degranulation suppressed hat msc conclusion intravenous infusion hat mscs alleviate regulation cell function
background parenteral nutrition life sustaining therapy appropriate clinical settings hospital setting nondiabetic patients develop hyperglycemia subsequently require long term insulin receiving whether similar hyperglycemia seen outpatient setting unclear methods studied patients enrolled mayo clinic home parenteral nutrition hpn program january december patients excluded diabetes mellitus type previously received hpn taken corticosteroids risk refeeding syndrome results enrolled patients met inclusion criteria patients requiring addition insulin hpn mean age insulin requiring group higher non insulin requiring group nir years years men group men nir group mean blood glucose baseline starting infusion patients nir patients stepwise multivariate analysis assessing risk developing hyperglycemia age conclusions hyperglycemia common finding use hospital ambulatory setting patients without previous diagnosis age significant predictor requirement insulin present study hyperglycemia managed appropriately insulin therapy long term complications minimized
main objective research project develop new type hybrid glulam beam increase performance timber structural element combining ultra high performance concrete short fibre reinforcement uhpc sfr hybrid beam obtained layered structures obtained combining glued laminated glulam wood beam uhpc sfr lamellae bonded top bottom faces obtained hybrid beam possesses lower bending stiffness glulam beam similar overall dimensions higher ultimate load capacity two models developed validate concept presented paper first analytical model based hypotheses related usual strength materials second finite element model load displacement moment curvature relationships models compared experimental results obtained large scale specimens results show good correlation analytical modelling experimental results illustrate potential applications composite beam configurations civil engineering structures elsevier inc rights reserved
study investigated effect bright blue enriched versus blue suppressed indoor light sleep wellbeing healthy participants years twenty nine participants private houses uniform settlement copenhagen exposed two light epochs weeks blue enriched lux weeks blue suppressed lux indoor light vice versa randomized cross design first light epoch october second november two light epochs separated one week participants examined baseline end light epoch experimental indoor light well tolerated majority participants sleep duration hours blue enriched conditions hours blue suppressed conditions neither rest hours chromatic pupillometry saliva melatonin profile showed significant changes blue enriched blue suppressed epochs baseline pittsburgh sleep quality index psqi significantly worse females versus males females psqi improved significantly blue enriched light exposure significant changes found males subjective grading indoor light quality doubled participants habitual indoor light bright experimental light stable light epochs although clear differences blue enriched blue suppressed electrical light conditions imposed even though study carried late autumn northern latitude significant difference actiwatchmeasured total blue light exposure contributions blue enriched bright indoor light superseded contributions daylight
task generating network based evidence support network forensic investigation becoming increasingly prominent undoubtedly evidence significantly imperative used diagnose respond various network related issues performance bottlenecks routing issues etc importantly leveraged infer investigate network security intrusions infections context paper proposes proactive approach aims generating accurate actionable network based evidence related groups compromised network machines approach envisioned guide investigators promptly pinpoint malicious groups possible immediate mitigation well empowering network digital forensic specialists examine machines using auxiliary collected data extracted digital artifacts one hand promptness approach successfully achieved monitoring correlating perceived probing activities typically first signs infection misdemeanors hand generated evidence accurate based anomaly inference fuses big data behavioral analytics conjunction formal graph theoretical concepts evaluate proposed approach global capability security operations center empirical evaluations employ real darknet traffic indeed demonstrates accuracy effectiveness simplicity generated network based evidence
redundancy checking key knowledge reduction technology extension rule new reasoning method first presented well received experts home abroad novel extension rule ner improved based reasoning method presented paper first analyse characteristics extension rule present simple algorithm redundancy checking based extension rule rcer addition introduce mimf type heuristic strategy using aforementioned rule strategy design implement rcher algorithm relies mimf next design implement rcner redundancy checking based ner algorithm based ner parallel computing greatly accelerates ner algorithm weak dependence among tasks executed considering present pner parallel ner apply redundancy checking necessity checking furthermore design implement rcpner redundancy checking based pner ncppner necessary clause partition based pner algorithms well experimental results show mimf significantly influences acceleration algorithm rcer formulae large scale high redundancy comparing pner ner rcpner rcner average speedup reach number task decompositions executed comparing ncpner rcner based algorithm separating redundant formulae speedup increases steadily scale formulae incrementing finally describe challenges extension rule faced suggest possible solutions
rainwater harvesting utilization important role play harnessing production potential within dryland systems study assesses performance small rainwater harvesting structures farm ponds major rainfed states india period using data multiple sources stakeholders rainwater harvested using structures varying types sizes used either supplemental irrigation recharging open wells many cases farm level rainwater harvesting structures highly effective rainfed farming multiplier effect farm income situations however viewed farmers waste productive land use farm ponds maharashtra example resulted significant increase farm productivity cropping intensity consequently farm income chittoor district andhra pradesh farm pond water profitably used supplemental irrigation mango plantations vegetables crops animal enterprises net returns estimated structure annum despite examples adoption farm ponds low except maharashtra functional analysis reasons high adoption water harvesting structures indicated factors technical support customized design level farmer participation age existing ownership open wells annual rainfall household assets major determinants performance farm level rainwater harvesting structures based countrywide analysis different policy institutional options proposed promoting farm level rainwater harvesting dryland agriculture elsevier rights reserved
study aimed investigate physicochemical properties antidiabetic effects polysaccharide obtained corn silk pcs pcs isolated physicochemical properties characterized hypoglycemic effects determined using high fat diet streptozocin induced type diabetic mellitus tdm insulin resistance mice results showed pcs heteropolysaccharide average molecular weight kda pcs composed galactose mannose glucose xylose arabinose rhamnose pcs treatment significantly reduced body weight loss decreased blood glucose serum insulin levels improved glucose intolerance levels serum lipid profile regulated levels glycated serum protein non esterified fatty acid decreased significantly activities superoxide dismutase glutathione peroxidase catalase notably improved pcs also exerted cytoprotective action histopathological observation results suggested pcs could good candidate functional food medicine tdm treatment elsevier ltd rights reserved
aiming improving unideal testing result means analog signal processing wavelet analysis introduced nondestructive testing steel iron materials based characteristics electromagnetic nondestructive testing signal according requirement wavelet algorithm hardware advantages dsp digital signal processing function high calculating speed design scheme steel electromagnetic nondestructive testing device proposed paper experiments show method extract detection signal effectively
distribution network low voltage nominal defined consumer medium voltage nominal selected discretion different various countries costs network sensitive medium voltage nominal obviously lower voltage better studied model showed costs abruptly diminish load density sizes fed zones growing certain limit cost voltage losses little sensitive voltage nominal uniform load density cost slightly growing medium voltage non uniform load density thick load alternates sparsely populated area network costs critical medium voltage due voltage loss latter strongly diminishing medium voltage growing making possible increase medium voltage fed zone dominated equipment prices economic indices
paper presents several mechatronics equipments low cost small scale employing components technology applied model building systems developed built students different levels knowledge pontifical catholic university rio janeiro aid teaching learning research engineering particularly control automation mechanical mechatronics fields ifac international federation automatic control hosting elservier ltd rights reserved
proportional integral derivative pid controller frequently used controller design industrial applications favorable response simplicity adjustment however pid manual tuning traditionally based engineering experience adjusting nonlinear unknown systems extremely difficult promoting intelligent controller design theory applied control various systems paper proposes nonlinear control design method involves determining optimal solution obtaining transfer function unknown system using sequential quadratic programming addition paper presents case study induction motor speed control demonstrate effectiveness proposed method based matlab simulation results prove design proposed intelligent pid controller robust traditional controller designs
engineering courses benefit using remote laboratories support aching activities online learning remote control system effective tool used practical classes enhance students experimental skills online experimentation also otters important support engineering teaching used improve students learning process instance electrical engineering courses particularly topics related systems automatic control paper describes online experiment demonstration propped remote lab system aiming identifying model given nonlinear system design apply controllers based different methodologies experimental setup used interact remote lab web based platform students visualize collect data real time available remote system ifac internatioilal rederation automatie control hostieg elsevier ltd rights reserved
evolution design test results novel permanent magnet generator use direct drive wind turbines presented generator topology based steel core modules make rotor air cored stator winding topology allows reduction structural mass large diameter generators lead lightweight generators copyright john wiley sons ltd
light emitting diode led based visible light communication vlc system provide lighting communication simultaneously attracted much attenuation recently photovoltaic cell also known solar cell physically flexible low cost easily available could good choice vlc receiver furthermore besides acting vlc solar cell convert vlc signal electricity charging devices hence could promising candidate future internet thing iot networks however using solar cell vlc challenging since response solar cell highly limited limit vlc data rate work propose demonstrate first time using pre distortion manchester coding signal enhance signal performance solar cell based vlc proposed scheme significantly mitigate slow response well direct current wandering effect solar cell hence times increase data rate experimentally achieved
several systematic reviews suggest acupuncture effective knee osteoarthritis furthermore safe cost effective treatment condition recent clinical practice guideline cpg national institute health care excellence nice united kingdom recommended use acupuncture grounds effect size comparison sham acupuncture small safety data considered review addition levels evidence acupuncture recommended therapies compared consequently argued nice guideline limitations lead several potential biases evaluation acupuncture addressed correctly nice prior scoping process limited review nice introduced method developing recommendations based consideration interventions make minimal important differences greater rather statistical significance effect intervention compared appropriate comparison evidence sham acupuncture physiologically inert level beneficial effect hence artificially reducing magnitude comparison sham low adverse effects profile acupuncture evidence trials comparing acupuncture usual standard care considered cost effectiveness data lack usual cpg head head comparisons interventions criteria methods applied acupuncture applied nice recommended therapies knee including patient centeredness patient education self management weight loss nonsteroidal anti inflammatory drug nsaids cyclooxygenase inhibitor cox inhibitors would longer recommended opiates would become first line drug prescription given problems sham acupuncture perhaps time embrace pragmatic studies employ comparative effectiveness studies instead
advent large complex datasets nosql databases gained immense popularity efficiency handle datasets comparison relational databases number nosql data stores mongo apache couch etc operations data stores executed quickly paper aim get familiar popular nosql databases elasticsearch apache couchdb paper also aims analyze performance elasticsearch couchdb image data sets analysis based results carried instantiate read update delete operations document oriented stores thus justifying couchdb efficient elasticsearch insertion updation deletion operations selection operation elasticsearch performs much better couchdb implementation done linux platform
survey genetic improvement general purpose computing graphics cards summarise several experiments demonstrate four themes experiments gzip program show genetic programming automatically port sequential code parallel code experiments stereocamera program show upgrade legacy parallel code new hardware software experiments niftyreg barracuda show make substantial improvements current parallel cuda applications finally experiments pknotsrg program show semi automated approaches enormous speed ups sometimes growing grafting new code genetic programming combination human input
background objective examined seasonality winter seasonal affective disorder sad old order amish lancaster county pennsylvania unique population prohibits use network electric light homes methods estimated sad using seasonal pattern assessment questionnaire spaq amish adults compared frequencies sad total sad presence either sad subsyndromal sad men women young old awareness ever never heard sad heritability global seasonality score gss estimated using maximum likelihood method including household effect capture shared environmental effects results mean gss prevalence sad total sad heritability gss adjusting age gender household effects limitations limitations include likely overestimation rates sad spaq possible selection bias recall bias limited generalizability study conclusions amish gss sad prevalence lower observed earlier spaq based studies predominantly caucasian populations low heritability sad suggests dominant environmental effects effects awareness age gender sad risk similar previous studies identifying factors resilience sad face seasonal changes amish could suggest novel preventative therapeutic approaches reduce impact sad general population elsevier rights reserved
purpose explore agreement cancer occurrence site among medicare part massachusetts cancer registry death certificates methods linked data sources cohort population based east boston senior health project component national institute aging established populations epidemiologic studies elderly cohort consists subjects dying january december results detected following agreements cancer occurrence hospitalization data death certificates kappa hospitalization cancer registry data kappa cancer registry death certificate data kappa measures agreement changed little analyses stratified age sex calendar year place death autopsy performance cigarette smoking alcohol consumption site specific agreements higher colorectal respiratory tract cancer compared breast prostate across ail three comparisons conclusions results assist epidemiologists better understand strengths limitations data sources elsevier science inc
imperative soil improvement technique considerably affect soil media mechanical behavior however considering recent researches concluded combined study effect cement treatment soil geotextile interfacial shear strength parameters almost neglected thus main objective study fill research gap main focus selected site shiraz city iran regard shear strength parameters untreated cement treated soil samples acquired traditional modified direct shear tests apparatuses results indicate high cement contents soil geotextile interfacial shear strength increases observed behavior similar consolidated soils cement treatment improve properties adding cement increased friction angle cohesion soil considerably complementary microscopic evaluation interface indicated interfacial soil geotextile shear strength highly dependent upon soil particles size distribution specially fines content finally numerical modeling illustrative reinforced soil structure revealed knowing state stress prerequisite selection soil improvement zone sharif university technology rights reserved
objective assess body distribution timing appearance rest tremor parkinson disease methods information obtained computerized database containing historical information collected first visit data collected subsequent follow visits information rest tremor developed follow could therefore obtained observation proportion patients results among patients rest tremor reported disease onset cases detected last follow examination patients analysis patients report rest tremor disease onset indicated patients overall population manifested rest tremor disease course rest tremor spread new sites patients manifested rest tremor disease onset regardless tremor presentation disease onset follow upper limb frequent tremor localization follow rest tremor developed faster upper limb body sites risk developing rest tremor follow affected sex side motor symptom onset site tremor presentation however age disease onset years associated increased risk rest tremor spread conclusions study provides new information body distribution timing rest tremor appearance course early stages parkinson disease may help clinicians patients counselling elsevier rights reserved
study economic performances consecutive multi span suspension bridges carried part study material amount structural cost estimation formulas bridges derived based structural ultimate carrying capacity bridge cost includes part superstructure part substructure three types bridge foundations bored piles concrete caissons floating foundations considered substructure formulas used parametric study bridge cost order define economical layout different conditions part two study
paper focuses marital birth control practices era widespread uniform adoption modern contraceptives two nearby swiss cities characterized different religious cultures asks responsibility contraceptive practices shared within marital couple whether object discussion spouses choice method contraception made religious culture affected elements paper uses written sources reflecting medical authorities views birth control semi structured interviews elderly persons lower middle working classes results point three key conclusions firstly findings show joint responsibility spouses contraceptive practices secondly paper shows religious culture plays key role access means birth control specifically fribourg gynecologists reluctant prescribe modern methods thirdly results underline combination methods used throughout reproductive life depending spouses desire additional children men women individual attitudes toward birth control methods
article presents proposal detection programming source code similitude academic environments objective proposal provide support professors detecting plagiarism student homework assignments introductory computer programming courses developed tool codesight based modification greedy string tiling algorithm tool tested one theoretical three real scenarios obtaining similitude detections assignments ranging contained code without modifications assignments containing insertions procedural instructions inside main code results verified efficiency tool first five levels plagiarism spectrum programming code addition supporting suspicions plagiarism real scenarios wiley periodicals inc comput appl eng educ view article online doi
objective work minimize testing cost analog circuits complete specification tests available use integer linear program ilp eliminate many tests possible without exceeding required defect level method leverages correlation among specifications thereby avoiding tests specifications sufficiently covered tests specifications first monte carlo simulation determines probabilities test covering specifications originally intended probabilities given defect level define ilp model eliminating unnecessary tests hypothetical example illustration ten specifications demonstrates depending defect level requirement half tests may eliminated monte carlo simulation using spice probabilistic characterization tests versus specifications followed ilp optimization two commercially available integrated circuits operational amplifier radio frequency power controller rfpc presented evidence effectiveness technique
present channel front end readout board openpet electronics system major task developing nuclear medical imaging system positron emission computed tomograph pet single photon emission computed tomograph spect electronics system wide variety detector camera design concepts relatively simple nature acquired data allows common set electronics requirements met flexible scalable high performance openpet electronics system analog signals different types detectors used medical imaging share similar characteristics allows common analog signal processing openpet electronics processes analog signals detector boards report development channel detector board signal digitized continuously sampled analog digital converter adc processed field programmable gate array fpga extract pulse height information leading edge discriminator creates timing edge time stamped time digital converter tdc implemented inside fpga digital information channel sent fpga services analog channels information multiple channels processed fpga perform logic crystal lookup doi calculation calibration etc
hanging type sand retaining wall common sand blocking fence structure used prevent sand movement type wall widely used along qinghai tibet gobi desert railways xinjiang western china analyze characteristics wind sand flow fields effect sand fence structure wind tunnel test field test carried wind tunnel test showed zoning characteristics flow fields effect hanging type sand retaining wall field test provided sediment transport data effective wind proof interval sand resistance data front behind sand retaining wall consistency wind sand flow fields spatial distribution characteristic wind carried sand motion verified correspondences acceleration zone flow field negative elevation points percentage variations sand collection rate spatial distribution characteristic field sand collection data showed spatial structural characteristic sandy air currents action hanging type sand retaining wall sand resistance characteristic sand retaining wall systematic study wind sand flow fields control hanging type sand retaining wall provides theoretical basis rational layout sand control engineering systems efficient utilization hanging type sand retaining wall
cluster headache rare underdiagnosed primary headache disorder severe unilateral pain autonomic symptoms clinical characteristics korean patients yet reported analyzed clinical features patients university hospitals korea among total patients patient chronic average age patients years range years average age onset years range years male female ratio among teen onset among twenties onset pain severe visual analogue scale average duration attack minutes bout lasted weeks autonomic symptoms present restlessness agitation present patients patients suffered range bouts range years diurnal periodicity season propensity present patients respectively sex differences associated symptoms diurnal seasonal periodicity korean patients high male female ratio relatively short bout duration low proportion chronic unlike patients western countries
recently sparse graph based discriminant analysis sgda developed dimensionality reduction classification hyperspectral imagery sgda graph constructed norm optimization based available labeled samples different traditional methods nearest neighbor euclidean distance weights graph derived via sparse representation automatically select discriminative neighbors feature space however sparsity based graph represents sample individually lacking global constraint specific solution consequence sgda may ineffective capturing global structures data overcome drawback sparse low rank graph based discriminant analysis slgda proposed low rank representation proved capable preserving global data structures although may result dense graph slgda informative graph constructed combining sparsity low rankness maintain global local structures simultaneously experimental results several different multiple class hyperspectral classification tasks demonstrate proposed slgda significantly outperforms state art sgda
optimizing transition child adolescent mental health services camhs adult mental health services amhs priority healthcare systems purpose systematic review identify compare models care may used facilitate transition camhs amhs discuss trends implications inform future research practice results identified three models care move beyond healthcare services incorporate broader range services better meet dynamic needs transition aged youth joint working among providers coupled individualized approaches essential facilitating continuity care
mediterranean ecosystems particularly vulnerable environmental changes occurred last decades evaluating ecosystem response changes therefore top priority particularly concerning water carbon dynamics pianosa island well known test site numerous environmental surveys performed fully characterize typical vegetation type mediterranean macchia first measurement campaign concerning vegetation soil properties performed repeated soil properties vegetation cover characterized means aircraft high resolution lidar dataset taken additional medium low spatial resolution satellite images landsat oli modis aircraft photos recovered various sources availability datasets offers unique opportunity develop test methodology capable modelling analyzing water carbon dynamics mediterranean macchia decade aim simulation procedures integrating remotely sensed ancillary data first tuned towards available observations vegetation biomass soil carbon content procedures applied produce daily estimates macchia actual evapotranspiration aet gross primary production gpp net ecosystem exchange nee whose accuracy assessed corresponding eddy covariance flux tower observations taken two years results obtained satisfactory support capability modelling approach reproduce water carbon dynamics macchia study decade ecological viewpoint fluxes increasing time period mainly depending similarly increasing spring rainfall macchia ecosystem behaves net sink carbon stored primarily soil congruent secondarily vegetation elsevier rights reserved
research intergroup contact grown exponentially past decade research typically extolled benefits positive interaction members historically divided communities particularly outcomes related prejudice reduction emerging work field however qualified optimistic picture identifying three gaps existing literature first everyday life contact may construed negative experience increases rather decreases responses prejudice anxiety avoidance second real life settings contact often circumscribed informal practices segregation easily overlooked researchers rely primarily examining structured contact explicit processes using primarily laboratory questionnaire methods third positive contact may ironic effects political attitudes behaviors historically disadvantaged undermining recognition social injustice decreasing willingness engage collective action challenge status quo although truism intergroup contact reduce intergroup prejudice developments emphasize importance maintaining critical perspective contact hypothesis model promoting social change historically divided unequal societies also lay foundations future developments field
aim present study offer validated decision model casino enterprises model enables users perform early detection problem gamblers fulfill ethical duty social cost minimization end interpretation casino customers nonverbal communication understood signal processing problem indicators problem gambling recommended delfabbro identifying problem gamblers gambling venues final report combined viterbi algorithm interdisciplinary model helps decoding signals emitted casino customers model output consists historical path mental states cumulated social costs associated particular client groups problem non problem gamblers simulated investigate model diagnostic capability cost minimization ability group consisted subjects subsequently enlarged subjects approximately cases mental states correctly decoded problem gamblers statistical analysis using planned contrasts revealed model relatively robust suppression signals performed casino clientele facing gambling problems well misjudgments made staff regarding clients mental states last mentioned source error occurs pronounced manner judgment extremely faulty cumulated social costs might distorted
bridging anticoagulation commonly prescribed patients atrial fibrillation initiating warfarin require interruption anticoagulation current guidelines recommend bridging patients high risk stroke among patients atrial fibrillation one risk factors ischemic stroke recently published bridge trial found forgoing bridging interruption average noninferior bridging respect ischemic complications significantly fewer hemorrhagic complications sought examine benefits harms bridging anticoagulation across spectrum ischemic hemorrhagic stroke risk thereby enable nuanced risk stratified decision making bridging considered initiation interruption vitamin antagonists monte carlo simulation using combination literature derived estimates registry data trial data net clinical benefit weighting ischemic strokes intracranial hemorrhages extracranial major hemorrhages benefits harms bridging anticoagulation vary according underlying patient risk profiles thromboembolic stroke major intracranial bleeding patients high risk ischemic stroke low risk hemorrhage derive benefit bridging initiation interruption warfarin therapy patients similarly high low risk outcomes may receive benefit bridging initiation bridging interruption sensitive underlying assumptions need stratification along axes risk robust wide range parameters bridging anticoagulation may provide benefit patients high risk ischemic stroke low risk intracranial hemorrhage initiating interrupting warfarin therapy patients high low risk complications may harmed use bridging anticoagulation patients non valvular atrial fibrillation considered stratification risk ischemic hemorrhagic complications
internet global system interconnected networks carries extensive array information resources services key requirements include good quality service protection infrastructure nefarious activity distributed denial service ddos attacks network monitoring essential network engineering capacity planning prevention mitigation threats develop open source architecture packet monitor amon online monitoring analysis multi gigabit network streams leverages high performance packet monitor ring readily deployable commodity hardware amon examines packets partitions traffic sub streams using rapid hashing computes certain real time data products resulting data structures provide views intensity connectivity structure network traffic time scale routing proposed integrated framework includes modules identification heavy hitters well visualization statistical detection time onset high impact events ddos allows operators quickly visualize diagnose attacks limit offline time consuming post mortem analysis demonstrate system context real world attack incidents validate state art alternatives amon deployed currently processing multi gigabit live internet traffic merit network extensible allows addition statistical filtering modules real time forensics
growing evidence supporting use lay health workers lhws address treatment gap common mental disorders cmd task shifting study looks experience lhws delivering problem solving therapy pst intervention cmd people living hiv plwh primary health care setting semi structured interviews lhws plwh received pst carried using thematic content analysis year period lhws developed indigenous concepts pst opening mind kuvhura pfungwa uplifting kusimudzira strengthening strengthening kusimbisa kusimbisisa respectively using terms locally conceived knowledge sharing amongst lhws made acceptable deliver pst part daily work indigenous terms conceived developed lwhs describe components processes pst contribute therapy acceptability continued use primary care facilities
hypothesis drying constitutes key step production thin particulate films complex microstructure develops functional additives redistribute throughout film thus shaping film properties onset pore emptying constitutes paramount marker film formation process capillary liquid transport emerges experiments film shrinkage development surface liquid content liquid depletion surface pores thin films studied means novel experimental approach using example lithium ion battery anodes optical brightener incorporated films produced convective slot nozzle dryer various drying times images film emit light fluorescently exposure radiation captured analyzed image processing film shrinkage observed means laser displacement sensor findings soon first pores empty pore fluid transported convectively exerting external force pressure surge film transition fully saturated partially emptied film revealed significance drying rate particle shape studied show liquid depletion surface pores occur prior concurrent end film shrinkage elsevier inc rights reserved
background isoflavones class phytoestrogens considered important raw material healthcare products mainly dietary supplements hormone replacement active ingredients skin care cosmetics many scientific reviews found regarding extraction analysis methods biological activities compounds however emphasized date studies found concerning technological mapping patents involving isoflavones scope approach present study aimed map patents covering last years technology innovation comprising isoflavones patent survey conducted years international patent database espacenet using title keywords isoflavones genistein daidzein glycitein biochanin formononetin key findings conclusions resulting data allowed identification major countries universities companies invest products containing compounds addition patents separated interest groups three clusters discussed study processes obtaining enriched isoflavone fractions different plant materials intended healthcare products dietary supplements use isoflavones cosmetic products incorporation isoflavones micro nanostructured systems mask unpleasant tastes overcome low water solubility bioactive forms conclusion study along literature reviews could assist designing strategic research worldwide development new products containing isoflavones elsevier ltd rights reserved
background although theophylline shown anti inflammatory effects therapeutic use theophylline sepsis unknown aim study determine effect theophylline copd patients presenting sepsis methods nationwide population based propensity score matched analysis used data linked administrative databases taiwan national health insurance program patients copd hospitalized sepsis divided theophylline users non users primary outcome day mortality secondary outcome hospital death intensive care unit admission need mechanical ventilation cox proportional hazard model conditional logistic regression used calculate risk groups results propensity score matched cohort theophylline users non users included compared non users day day day overall mortality significantly lower theophylline users additionally theophylline users also lower risk hospital death need mechanical ventilation conclusions theophylline use associated lower risk sepsis related mortality copd patients pre hospital theophylline use may protective copd patients sepsis elsevier ltd rights reserved
study young black msm ybmsm explored correlates outcomes enhanced sexual pleasure condom protected sex six hundred ybmsm enrolled sexually transmitted infection clinic southern united states men completed computer assisted self interview item scale assessed perceptions related condoms enhancing sexual pleasure nine correlates met screening level significance tested regression model three obtained multivariable significance men discussing condom use sex partners greater odds aor experiencing enhanced pleasure insertive partners lower odds aor experiencing enhanced pleasure men scoring higher internalized homophobia lower odds aor experiencing enhanced pleasure also men experiencing enhanced pleasure less likely report condomless anal sex experience enhanced sexual pleasure condom protected sex may important target behavioral intervention efforts
beneficial effects ginger management gastrointestinal disturbances reported study anti inflammatory potential ginger extract assessed cellular model gut inflammation addition effects ginger extract major active compounds intestinal barrier function evaluated response caco cells following exposure mixture inflammatory mediators interleukin beta lipopolysaccharides lps tumor necrosis factor tnf alpha interferon inf gamma assessed measuring levels secreted addition mrna levels cyclooxygenase inducible nitric oxide synthase measured moreover degree nuclear factor kappa inhibition examined intestinal barrier function determined measuring transepithelial electrical resistance teer fluorescein isothiocyanate fitc dextran transfer observed ginger extract constituents improved inflammatory responses decreasing levels nitrite pge via kappa inhibition ginger extract also increased teer decreased transfer fitc dextran apical side epithelium basolateral side taken together results show ginger extract may developed functional food maintenance gastrointestinal health
iodine essential trace element synthesis thyroid hormones excessive well deficient iodine ingestion adversely affects thyroid function major sources iodine japan edible seaweeds namely nori wakame kombu iodine content kombu ranges although japan regarded non goitrous iodine excess country cases endemic goiter northern island hokkaido could tracked back however recent data relationship iodine status thyroid dysfunction available surveillance system monitor iodine intake nationwide school based survey throughout japan conducted february survey covered children schools across prefectures overall median urinary iodine concentration sites combined suggesting iodine sufficiency excess
paper reviews literature sex cultural differences physical aggression argues understanding interactions among evolutionary predispositions hormonal influences social situational factors possibly make sense patterns human aggression see around specifically proposed process natural selection shaped hormonal responses males sensitive situations involving challenges status competition males hormonal changes essential ingredients aggressiveness occurs situations models aggression focus situational cognitive emotional triggers aggressive behavior attempt understand human aggression without reference biology destined incomplete best elsevier ltd rights reserved
known objectivecentenarians represent population individuals delayed disability ideal representation ageing well however studies related medicine use population scarce study aimed explore temporal trends associated utilization preventive medicines centenarians methodsa repeated cross sectional analysis conducted january december individuals years old date dispensing captured new zealand pharmaceutical claims data set variable medication possession ratio vmpr used identify medicines use preventive calculated aggregating days supply first last prescription divided time last prescription date plus days supply first prescription date poisson regression used examine dispensing trends low dose aspirin clopidogrel warfarin dabigatran statins bisphosphonates vmpr resultsdispensing aspirin incident rate ratio irr clopidogrel irr aspirin clopidogrel irr declined significantly study period similar trends observed statins irr bisphosphonates irr utilization anticoagulants studied increased significantly warfarin irr dabigatran irr new conclusionover decade dispensing preventive medicines centenarians decreased marginally antiplatelets statins substantial decrease bisphosphonates use increase anticoagulant use noted period temporal trends provide opportunity investigate uptake guideline based prescribing age group
although vaccination promising way combat nicotine addiction traditional hapten protein conjugate nicotine vaccines show limited efficacy due poor recognition uptake immune cells study aimed develop hybrid nanoparticle based nicotine vaccine improved efficacy focus study impact hapten density immunological efficacy proposed hybrid nanovaccine shown nanovaccine nanoparticles taken dendritic cells efficiently conjugate vaccine regardless hapten density nanoparticles similar hapten density nanovaccine induced significantly stronger immune response nicotine conjugate vaccine mice moreover high medium density nanovaccines resulted significantly higher anti nicotine antibody titers low density counterpart specifically high density nanovaccine exhibited better immunogenic efficacy resulting higher anti nicotine antibody titers lower anti carrier protein antibody titers medium low density versions high density nanovaccine also best ability retain nicotine serum block nicotine entering brain results suggest hybrid nanoparticle based nicotine vaccine elicit strong immunogenicity modulating hapten density thereby providing promising next generation immunotherapeutic strategy nicotine addiction elsevier ltd rights reserved
modern operating systems memory mapped mmio important access method maps file file like resource region memory mapping allows applications access data files memory semantics load store provides ease programming number applications use mmio increasing memory semantics provide better performance file semantics read write data located main memory performance applications enhanced owing effect large cache mmio used hot data tend reside main memory cold data located storage devices hdd ssd data placement memory hierarchy depends virtual memory subsystem operating system generally performance storage devices direct impact performance mmio widely expected better storage devices lead better performance however expectation limited fast storage devices used since virtual memory subsystem reflect performance feature devices article examine linux virtual memory subsystem mmio path determine influence fast storage existing linux kernel throughout investigation find overhead linux virtual memory subsystem negligible hdd prevents applications using full performance fast storage devices reduce overheads fully exploit fast storage devices present several optimization techniques modify linux kernel implement optimization techniques evaluate prototyped system low latency storage devices experimental results show optimized mmio better performance original mmio also compare system system enough memory keep data main memory system insufficient memory mmio achieves performance resource rich system result implies virtual memory subsystem mmap effectively extend main memory fast storage devices
bio electrochemical strategy developed constructing simple sensitive levofloxacin lev sensor based single chamber microbial fuel cell mfc using fepo nanoparticles nps cathode catalyst instead traditional assembled sensor device fepo nps dramatically promoted electrooxidation oxygen cathode helps accelerate voltage output mfc provide powerful guarantee lev detection scanning electron microscopy sem ray diffraction xrd fourier transform infrared ftir ray photoelectron spectroscopy xps used fully characterize fepo nps optimized cod condition lev concentration range could detected successfully exhibited excellent linear interval concentration range range concentrations lev temporary effect anode exoelectrogenic bacterial less min could occur came back normal exhibited long term stability maintaining stable electricity production months continuous running besides detection mechanism investigated quantum chemical calculation using density functional theory dft
investigation paper dimensional broer kaup kupershmidt system nonlinear dispersive long gravity waves two horizontal directions shallow water uniform depth bilinear forms backlund transformation lax pair derived based bell polynomials symbolic computation one two soliton solutions real function phi constructed via hirota method scaled space coordinate propagation interaction solitons illustrated graphically phi affects shape solitons interaction solitons including elastic inelastic interactions discussed solitons interaction elastic amplitude velocity shape soliton remain invariant interaction except phase shift smaller amplitude soliton larger phase shift iii height water surface horizontal bottom bell shaped soliton upside bell shaped soliton certain conditions horizontal velocity water wave always keeps bell shaped published elsevier
weak separation user kernel space modern operating systems facilitates several forms privilege escalation paper provides survey protection techniques cutting edge time tested used prevent common privilege escalation attacks techniques compared terms effectiveness performance impact complexity implementation impact diversification techniques aslr overall literature provides litany disjoint techniques trades performance cost effectiveness particular isolated threat single technique found effectively mitigate known potential attack vectors reasonable performance cost overhead
inadequate skid resistance pavement surface substantial reason traffic accidents close relationship sliding resistance characteristics texture morphology demanding high precision comprehensive acquisition macrotexture microtexture morphology traditional three light sources photometric stereo method improved study fourfold first six light sources adopted enhance illumination eliminate incomplete information retrieval pavement surface image second low rank approximation proposed image processing stage significantly reduce interference noise highlights shadow resulting higher precision reconstructed pavement surface compared existing photometric stereo method using three light sources third unlike control point based weighting algorithm control point based surface interpolation algorithm established optimizes precision reconstructed surface combining effect global integration elevation positions relative points testing indoor conditions surface interpolation photometric stereo method control points using low rank approximation effectively measure macrotexture microtexture morphology last low rank approximation global integration six light sources used relax requirement surface interpolation photometric stereo method control points statistical analysis indicates low rank approximation global integration six light sources effective method reconstructing three dimensional macrotexture microtexture morphology american society civil engineers
objectiveseveral studies reported non demented older adults clinical depression show changes amyloid levels blood cerebrospinal fluid neuroimaging consistent observed patients alzheimer disease findings suggest may one mechanisms underlying relation two conditions sought determine relation elevated cerebral presence depression across month prospective observation period methodscognitively normal older adults australian imaging biomarkers lifestyle study depressed undergone positron emission tomography scan classify either high low participated depressive symptoms assessed using geriatric depression scale short form month intervals months resultswhilst difference probable depression groups baseline incidence confidence interval times greater within high group low group month assessment conclusionsresults study suggest elevated levels associated fold increased likelihood developing clinically significant depressive symptoms follow preclinical alzheimer disease underscores importance assessing monitoring treating depressive symptoms older adults elevated copyright john wiley sons ltd
minimal amount research examined cognitive predictors children performance naturalistic errand type planning tasks zoo map task behavioral assessment dysexecutive syndrome children bads thus current study examined prospection ability remember carry future intention executive functioning intelligence markers predictors performance widely used naturalistic planning task children aged years old measures planning prospection inhibition crystallized intelligence fluid intelligence collected individual differences study regression analyses showed prospection rather traditional measures intelligence inhibition predicted planning suggesting naturalistic planning tasks zoo map task may rely future oriented cognitive processes rather executive problem solving general knowledge
paper present new high accuracy multiplier circuits focused implementation original techniques improving linearity proposed structures new approach designing high precision multipliers using multifunctional cores presents important advantage allowing facile reconfiguration designed circuits multiplier core able implement multitude additional circuit functions amplifying squaring square rooting simulating positive negative equivalent resistance multiplier structures designed low voltage low power operation supply voltage implementing cmos technology current consumption smaller proposed multiplier
conducted meta analysis investigate overall incidence risk endocrine complications cancer patients treated inhibitors methods pubmed embase oncology conference proceedings searched relevant studies results comparison chemotherapy everolimus cetuximab control inhibitors significantly increased risk grade hypothyroidism relative risk hyperthyroidism relative risk hypophysitis compared ipilimumab control risk grade hyperthyroidism hypothyroidism inhibitors monotherapy seemed higher ipilimumab risk hypophysitis lower ipilimumab conclusion treatment inhibitors associated increased risk developing hypothyroidism hyperthyroidism hypophysitis
paper presents true rms converter based ddcc building block working wide range input current utilizing general purpose building block using small value capacitor makes circuit good candidate biomedical analog signal processing applications circuit implemented using standard current mode building block ddcc compared previous works circuit calculates true rms arbitrary shaped input current wider range amplitude higher accuracy output rms value deviate real value selected input shapes
paper presents distributed algorithmic solutions employ opportunistic inter agent communication achieve dynamic average consensus solutions agent endowed local criterion enables determine whether broadcast state neighbors starting point continuous time distributed coordination strategy continuous time communication achieves practical asymptotic tracking dynamic average time varying agents reference inputs algorithm depending directed undirected nature time varying interactions suitable connectivity conditions propose two different distributed event triggered communication laws prescribe agent communications discrete time instants opportunistic fashion cases establish positive lower bounds inter event times agent characterize dependence algorithm design parameters analysis allows rule presence zeno behavior characterize asymptotic correctness resulting implementations several simulations illustrate results elsevier ltd rights reserved
modern parallel computing programming models mapreduce proven powerful tools efficient parallel execution data intensive tasks entity matching era big data reason studies challenges possible solutions benefit well known cloud computing programming model become important demand nowadays furthermore effectiveness scalability based implementations depend well workload distribution balanced among reduce tasks article investigate mapreduce used perform efficient load balanced parallel using variation multi pass sorted neighborhood method snm uses varying size adaptive window propose multi pass mapreduce duplicate count strategy multimr dcs based approach multi pass adaptive snm aiming increase even performance snm evaluation results based real world datasets cluster infrastructure show approach increases performance mapreduce based snm regarding execution time detection quality elsevier inc rights reserved
background prior studies clinical prognostication idiopathic pulmonary fibrosis ipf using computed tomography often used subjective analyses evaluated quantitative measures isolation study examined associations densitometric local histogram based quantitative measurements pulmonary function test pft parameters mortality addition study sought compare risk prediction scores incorporate quantitative measures previously described systems methods forty six patients biopsy proven ipf identified registry patients interstitial lung disease brigham women hospital boston scans subject visually scored using previously published method semi automated method used segment lungs surrounding tissue densitometric measurements including percent high attenuating area mean lung density skewness kurtosis made entirety patient lungs separate automated tool used detect quantify percent lung occupied interstitial lung features analyses used create clinical quantitative based risk prediction scores performance compared performance clinical visual analysis based methods results densitometric measures correlated forced vital capacity diffusing capacity total amount interstitial change percentage interstitial change honeycombing measured using local histogram method higher percent high attenuating area higher mean lung density lower skewness lower kurtosis higher percentage honeycombing associated worse transplant free survival quantitative based risk prediction scores performed similarly clinical visual analysis based methods conclusions densitometric feature based quantitative measures correlate pulmonary function test measures associated transplant free survival objective measures may useful identifying high risk patients monitoring disease progression work needed validate measures quantitative imaging based risk prediction scores cohorts
introduction inappropriate use oral anticoagulants oacs well investigatedand however may frequent real world practice patients nonvalvular atrial fibrillation nvaf study designed evaluate prescription patterns appropriateness oacs patients nvaf real world clinical settings methods performed prospective observational study nct total patients nvaf screened oac prescription appropriateness prescribing evaluated using criteria medication appropriateness index mai indication choice dosage modalities practicability administration drug drug interactions drug disease interactions duplication duration criterion evaluator rate whether medication appropriate inappropriate limited clinical importance inappropriate results patients warfarin group rivaroxaban group dabigatran therapy group mai showed group group group patients least inappropriate criterion moreover according choice criterion group group group rated inappropriate dosage appropriate group group group conclusion inappropriate drug use frequent among patients nvaf warfarin also noacs although apparent improvement thromboprophylaxis nvaf much effort needed appropriate use oacs
insect cuticle works first line defence protect insects pathogenic infections water evaporation however old cuticle must shed order enter next developmental stage ecdysis moulting fluids produced secreted area among old new cuticles previous study protein bombyx mori single domain von willebrand factor type bmsvwc bgibmga identified moulting fluids mori demonstrated regulate ecdysis study show mori larvae bmsvwc primarily locates integument epidermal cells cuticle wing discs head moulting stage bmsvwc released moulting fluids produced epidermal cells ecdysis fungal infection shown decrease amount bmsvwc cuticle indicates bmsvwc target protein entomopathogenic fungi thus bmsvwc mainly involved maintaining integrity integument structure serves protect insects physical damage pathogenic infection
aims study investigated community dwelling adults definition trust health care providers interpersonal trust description attributes trustworthy provider factors influenced development loss trust background trust important part health care relationships however meaning trust patients well understood health care providers need understand meaning trust order build maintain therapeutic relationships patients design descriptive qualitative research design used investigate perceptions trust methods semi structured open ended interviews carried community dwelling adults participants recruited church groups senior health programs community programs interviews thematically analysed definitions interpersonal trust trust health care provider attributes trustworthy provider factors pivotal development loss trust health care provider results trust health care providers differed interpersonal trust role specific attributes individuals trust although influenced confidence provider competence strongly tied interpersonal caring attributes provider loss trust hand closely allied issues competency conclusions perceptions trust varied greatly among sample reinforcing significance tailoring approach patients individual basis relevance clinical practice assuming trusted based role nurses may facilitate development therapeutic relationship patients nurses health care providers need acutely aware patient trust clues pending loss trust study prior studies shown trust provider lost nearly impossible rebuild
determine efficacy physiotherapy behavior therapy find specific subgroups women overactive bladder syndrome might gain increased benefit therapy women micturitions per period included six nine therapy sessions held within day interval efficacy end point reduction micturitions episodes nocturia secondary outcomes included iciq oab iciq oabqol visual analog scales follow months levene test student test pearsona spearman correlations utilized well friedman test multivariable multilevel model women included mean age years standard deviation mean body mass index bmi reduction number micturitions per reduction day reduction episodes nocturia iciq oab iciq oabqol questionnaires well vas showed significant improvement persisting month follow addition multivariable model controlling age women overactive bladder syndrome therapy responded significantly better already therapy study shows efficacy physiotherapy behavior therapy women overactive bladder syndrome post therapy effect especially women prior treatment
cyber physical system cps emerging area work efficiently without proper software handling data business logic software middleware soul cps software development cps critical issue complicity large scale realistic system furthermore object oriented approach ooa often used develop cps software needs improvements according characteristics cps develop software cps environment new systematic approach proposed paper comes practice evolved software companies consists requirement analysis event oriented way architecture design data oriented way detailed design coding object oriented way testing event oriented way new approach based ooa difference compared ooa proposed approach different emphases measures every stage accord characteristics event driven cps cps software development one focus events functions objects case study smart home system designed reveal effectiveness approach shows approach also easy operated practice owing simplifications running result illustrates validity approach
aims objectivesto describe nurses believe almost continuous skin skin contact preterm infants weeks gestation backgroundskin skin contact hours per day become standard care preterm infants high technology neonatal intensive care units however units practice kangaroo mother care involves almost continuous skin skin contact designa qualitative descriptive design methodsan online questionnaire open ended questions administered nurses three neonatal units data analysed qualitative content analysis findingsnurses believed would lose control limited access infant would able provide adequate care nurses also believed mothers practicing almost continuous skin skin contact would feel trapped would experience stress could meet demands method conclusionsalthough nurses describe several documented benefits almost continuous skin skin contact underuse continues exist relevance clinical practicebeliefs described nurses important consider resolve goal implement provide kangaroo mother care
background clozapine remains evidence based treatment treatment resistant schizophrenia prediction clozapine response important developing stratified treatment studied potential predictors clozapine response applying functional assessments well service use procedures performed nationwide cohort study among individuals diagnosed schizophrenia denmark age years initiated clozapine treatment global assessment functioning gaf score registered clozapine initiation year follow clinical response defined hospitalization schizophrenia improvement gaf score moderate improvement increase substantial improvement increase gaf performed cox regression analysis report adjusted hazard rate ratios hrrs confidence intervals cis results among clozapine users registered gaf score remained hospital achieved moderate functional improvement substantial functional improvement potential predictors voluntary status clozapine initiation showed borderline statistical significance nonhospitalization hrr regarding functional improvement living partner strongest predictor almost threefold increased hrr female sex nonsignificantly associated functional improvement whereas chance substantial improvement decreased hrr year delay clozapine initiation among females conclusions living partner strongest predictor functioning clozapine initiation study although potentially indicating better premorbid functioning finding stresses need importance social support course treatment independent clinical factors
review application projective geometry interpretation growth human body submitted features use geometry electric circuit theory shown growth human body change regime parameters network interpreted projective transformations transformations possess invariants cross ratios four points common mathematical apparatus represents interdisciplinary approach view analogy processes different physical nature obtained results develop methodology application non euclidean geometries
movement fluids unsaturated zone plays important role many geoenvironrnental engineering problems examples include cover basal liner systems waste containment facilities geosynthetics widely used amongst many examples paper highlights importance assessing unsaturated characteristics geosynthetics influence behaviour engineered systems soils geosynthetics interact unsaturated conditions includes information water retention curve hydraulic conductivity function geosynthetics geotextiles geosynthetic clay liners gcls particular focus capillary barriers liner performance elevated temperatures interface friction respectively mechanisms involved development capillary barriers evaluated explain storage water interface materials contrasting hydraulic conductivity fine grained soil nonwoven geotextile potential desiccation gcls explained light application liquid waste impoundment elsevier rights reserved
range estimation electric vehicles evs important point carefree use motor loss parameters required estimate range evs however many electric motor manufacturers provide parameters without special permissions besides design stage many motor alternatives must considered complicates permission process several suppliers deal instead parameters torque speed curve efficiency map presented electric motor datasheets paper presents novel range estimation method uses efficiency map instead motor parameters calculate motor losses validate proposed method simulation experimental studies carried midi bus furthermore effect different battery capacities range heavy electric vehicle examined
water scarcity pertaining many interrelated issues rapid urbanisation increasing water pollution acknowledged around world water reuse emerged viable water conservation measure satisfy water demand many communities among diversity wastewater treatment processes membrane assisted treatment technologies employed different water reuse scenarios regard one critical problems select appropriate membrane technology water reuse scenario research therefore develops decision making framework selection wastewater treatment technology framework applied different non potable reuse scenarios south african cities suburban areas employing multi criteria analysis method results show approach able provide systematic rigorous analysis help comparing selecting wastewater technologies
traditional vaccination approaches live attenuated killed microorganisms among effective means prevent spread infectious diseases approaches nevertheless failed yield successful vaccines many important pathogens overcome problem methods developed identify microbial components protective immune responses elicited subunit antigens identified approaches enable production defined vaccines improved safety profiles however generally poorly immunogenic necessitating administration potent immunostimulatory adjuvants since safe effective adjuvants currently used vaccines approved human use available displaying poor potency inability stimulate types immune responses required vaccines specific diseases cytotoxic lymphocytes ctls treat cancers development new vaccines aided availability characterized platforms new adjuvants improving capacity rationally select adjuvants different applications one approach involves addition microbial components pathogen associated molecular patterns pamps stimulate strong immune responses subunit vaccine formulations conjugation pamps subunit antigens provides means greatly increase vaccine potency targeting immunostimulation antigen antigen presenting cell thus methods enable efficient inexpensive production antigen adjuvant fusions represent exciting mean improve immunity towards subunit antigens herein review four protein based adjuvants flagellin bacterial lipoproteins extra domain fibronectin eda heat shock proteins hsps genetically fused antigens enable recombinant production antigen adjuvant fusion proteins focus mechanisms action structural sequence requirements activity sequence modifications enhance activity simplify production adverse effects examples vaccines preclinical human clinical trials elsevier inc rights reserved
objective phase study assessed performance positron emission tomography pet brain images made flutemetamol injection detecting beta amyloid neuritic plaques japanese subjects methods seventy subjects probable alzheimer disease pad amnestic mild cognitive impairment amci cognitively normal healthy volunteers hvs underwent pet brain imaging intravenous flutemetamol injection mbq images interpreted normal abnormal neuritic plaque density five non japanese five japanese readers blinded clinical data primary efficacy analysis based pad data agreement non japanese readers image interpretations clinical diagnosis resulting estimates positive percent agreement ppa based subjects similar sensitivity negative percent agreement npa based hvs similar specificity secondary analyses included ppa npa japanese readers inter reader agreement ira intra reader reproducibility irr quantitative image interpretations standardized uptake value ratios suvrs diagnostic subgroup test retest variability five pad subjects safety results ppa non japanese readers ranged japanese readers npa ranged non japanese readers japanese readers majority image interpretations interpretations made independently readers resulted ppa values npa values non japanese japanese readers respectively ira irr strong composite suvr values mean multiple regional values allowed clear differentiation pad subjects hvs test retest variability ranged test retest agreement blinded visual interpretations readers flutemetamol injection generally well tolerated conclusion detection brain neuritic plaques japanese subjects using flutemetamol pet images gave results highly consistent clinical diagnosis non japanese japanese readers giving similar results inter reader agreement intra reader reproducibility high sets readers visual delineation abnormal normal scans corroborated quantitative assessment low test retest variability
deep venous thrombosis dvt major cause morbidity mortality manually scanning ultrasound probe brings heavy work load sonographers paper proposes novel mirror robotic scanning system system composed two arm robot linear probes master slave side kinect sensor vision servo master side sonographers hold one robot arm operate probe inspect one leg slave side robot follows master probe navigation kinect scans leg images legs segmented register get mirror matrix clustered viewpoint feature histogram cvfh descriptors segmented probe cad computer aided design training data calculated probe recognition leg phantom platform built mirror matrixes obtained correlation coefficients two legs calculated times icp iterative closest point calculated platform results initial experiment indicate idea feasible promising greatly improving inspection efficiently clinically method implemented pre operative procedures predict risk dvt may improve scanning efficacy
background latino populations disproportionately moved areas southeast midwest emerging destinations outside traditional latino enclaves recent years objective examine whether health care experiences differ traditional emerging destinations latino children research design defined traditional emerging destination counties based levels changes latino population measures linked restricted national survey children health along county level data area resource file census state local governments compare outcomes among latino children across destinations linear probability models adjusted individual level characteristics area level characteristics state fixed effects measures outcomes access usual source care unmet health care needs preventive health visit prior year family centered care results compared traditional destination counterparts latino children emerging destinations tended younger healthier likely families speaking english home latino children emerging destinations significantly less likely usual source care adjusting individual level county level variables dimensions access similar destinations conclusions differences usual source care may reflect lower supply culturally competent providers limited information seek care realized access care protective factors emerging destinations higher average incomes area lower community uninsurance rates might counteract negative effects emerging destinations
growing global awareness climate change ushered new era demanding policy financial behavioural innovations accelerate transition clean energy economy dramatic price decreases solar photovoltaics public policy underwritten expansion solar power accounting largest share renewable energy california rising fast countries germany italy governments efforts expand solar generation base integrate municipal regional national energy systems spawned several programs require rigorous policy evaluations assess effectiveness costs contribution paris agreement goals study exploit natural experiment northern california test capacity property assessed clean energy pace promote investment pace highly cost effective doubling residential installations elsevier ltd rights reserved
hereditary angioedema hae genetic condition characterized frequent episodes localized angioedema rare disorder primary care provider otolaryngologist dermatologist rheumatologist may encounter occasionally disease reviewed significant advances understanding genetics biology therapeutic management surrounding condition histamine mediated angioedema responds steroids antihistamines epinephrine whereas bradykinin mediated angioedema resistant interventions requires specialized therapy previously used medications significant adverse effects approved medications hae effective decreasing morbidity mortality patients condition review presentation diagnosis available pharmaceutical options hae explore limitations implementing recommended therapy
main objective study analyse outcomes total knee arthroplasty tka group patients least one self reported allergy group patients without reported allergies hypothesized significant negative influence clinical outcome scores tka patients self reported allergies four hundred seventy five patients undergone tka analysed preoperatively year surgery womac kss scores obtained patients yesavage depression questionnaire score also recorded scores patients without self reported allergies compared scores patients least one self reported allergy medical record preoperative scores similar groups womac post operative scores kss knee score worse group patients self reported allergies group without allergies scores yesavage depression questionnaire similar groups patients least one self reported allergy worse post operative outcomes terms womac kss knee scores tka patients without allergies poor outcomes seem related depression therefore research needed explain reported allergies could considered prognostic factor used counselling tka patients
variety catalysts recently developed electrocatalytic oxygen evolution readily integrated semiconducting light absorbers photoelectrochemical photocatalytic water splitting demonstrate efficient core shell photoanode highly active oxygen evolution electrocatalyst shell femnp semiconductor core rutile tio photoelectrochemical oxygen evolution reaction metal organic chemical vapor deposition single source precursor used ensure good contact femnp tio tio femnp core shell photoanode reaches theoretical photocurrent density rutile tio reversible hydrogen electrode simulated sun irradiation dramatic enhancement result synergistic effects high oxygen evolution reaction activity femnp delivering overpotential tafel slope dec koh conductive interlayer surface active sites semiconductor core boosts interfacial charge transfer photocarrier collection facile fabrication tio femnp core shell nanorod array photoanode offers compelling strategy preparing highly efficient photoelectrochemical solar energy conversion devices
web services provide functionalities users software products services require high quality quality parameters web cloud based applications includes scalability balancing workload high availability parameters objective paper improve performance web cloud based applications cloud based applications provide services users platform service paas infrastructure service iaas software service saas design development large scale computer model high storage demand processing intensive application tightly coupled infrastructure distributed computing applications one important services cloud applications infrastructure service iaas provides storage network computing cloud files virtual machines demand problem access applications scalability distributed computing interoperability grid applications proposed cloud service selection model find services demand provides cloud services quality parameters programming model simple api grid application saga provide data high performance grids connecting various applications use map reduce algorithm expected improve performance web services cloud based applications
bioethanol gasoline blends represent otto cycle engines consolidated alternative attempts reduce ghg emissions limit use fossil fuels however use alternative fuels strongly influence performance engines purpose study analyse output pollutant emissions four stroke engine fuelled bioethanol gasoline blends tests performed engine used broad applications specific modifications applied carburetion system order evaluate fuel flexibility capabilities tests evidenced mixture tends get lean alcoholic fuels brake specific fuel consumption increased due lower lhv bioethanol highest brake thermal efficiency obtained minor torque power reductions recorded ethanol blends concentration uhc decreased nox emissions reduced lower combustion temperature due bioethanol cooling effect leaner mixture contrast concentration increased poor homogenization charge lower combustion temperature facilitated formation partial oxidation products elsevier ltd rights reserved
objectivesto assess effect mirabegron cardiovascular end points adverse drug reactions real world japanese patients overactive bladder cardiovascular disease methodsparticipants overactive bladder history coexisting cardiovascular disease lead electrocardiogram carried days initiating weeks mirabegron treatment patients serious cardiovascular disease class iii new york heart association functional classification confirmed expert analysis excluded patient demographics physical characteristics cardiovascular history recorded weeks patients underwent another electrocardiogram incidence cardiovascular adverse drug reactions change baseline electrocardiogram parameters qrs intervals fridericia corrected heart rate assessed resultsof patients registered met criteria baseline post dose electrocardiograms male aged years coexisting cardiovascular disease notably arrhythmia angina pectoris starting mirabegron daily doses incidence cardiovascular adverse drug reactions weeks mean heart rate increased statistically significant clinically acceptable per previous trials significant changes observed qrs fridericia corrected significant correlations total population age sex segregated subgroups observed baseline fridericia corrected change weeks correlation heart rate versus change baseline heart rate treatment observed conclusionsmirabegron well tolerated real world japanese patients overactive bladder coexisting cardiovascular disease unexpected cardiovascular safety concerns observed
article examines social construction contestation gender gender roles city blantyre malawi fieldwork gendered household roles related food security interviews men women revealed distinct set connotations word gender reflected malawians historical contemporary engagement concepts development modernity human rights denote malawian concept gender gender order distinguish word participants used interviews widely accepted conventional definition use distinction highlight ways ideas gender equality introduced received malawian context urban setting research key drawing association gender westernization bringing focus power dynamics inherent project translating global discourses gender rights gender equality meaningful social change developing countries gender malawi denotes top outside process framing malawi goals gender equality creates political constraints form resistance gender resonates long history social change imposed outside forces form superficial adherence gender appear urban modern especially western researcher local understandings gender gender undermine efforts promote gender equality means address malawi intense urban poverty household food insecurity resumeneste articulo analiza construccion social disputa genero los roles genero ciudad blantire malaui trabajo campo sobre los roles generizados hogar relacion con seguridad alimentaria entrevistas con hombres mujeres revelaron conjunto distintivo connotaciones con palabra genero las cuales reflejaban envolvimiento historico contemporaneo los malauies con los conceptos desarrollo modernidad derechos humanos denotamos concepto malaui genero como genero con objetivo distinguir palabra que lxs participantes utilizan las entrevistas definicion convencional mas ampliamente aceptada luego utilizamos esta distincion para destacar las formas que las ideas igualdad genero han presentado recibido contexto malaui contexto urbano investigacion clave para identificar asociacion genero con occidentalizacion poniendo foco dinamica poder inherente del proyecto traducir los discursos globales los derechos genero igualdad genero cambios sociales significativos los paises desarrollo genero malaui denota proceso vertical arriba hacia abajo afuera hacia adentro definicion los objetivos malauies igualdad genero esto crea limitaciones politicas forma resistencia genero porque resuena con una larga historia cambio social impuesto por las fuerzas exteriores tambien forma adherencia superficial genero para parecer mas urbana moderna especialmente investigador occidental las formas locales entender genero como genero socavan los esfuerzos por promover igualdad genero como una manera abordar intensa pobreza urbana inseguridad alimentaria hogar malaui
linear max plus systems describe behavior large variety complex systems known systems show periodic behavior initial transient phase assessment length transient phase provides important information complexity measures systems crucial system design identify relevant parameters graph representation systems propose modular strategy derive new upper bounds length transient phase first give asymptotically tight potentially subquadratic transience bounds use bounds derive new complexity results particular distributed computing elsevier rights reserved
although well known role bone development mineral homeostasis emerging evidence vitamin capable functioning regulator skeletal muscle development hypertrophic growth review focus relatively limited body evidence regarding impact vitamin prenatal development postnatal growth skeletal muscle meat animal species recent evidence indicating improvement maternal vitamin status dietary hydroxycholecalciferol supplementation positively affect fetal skeletal muscle fiber number myoblast activity swine well work demonstrating posthatch vitamin status enhancement stimulates satellite cell mediated skeletal muscle hypertrophy response broiler chickens discussed relative lack information regarding best supply dietary vitamin promote optimal prenatal development postnatal growth skeletal muscle provides exciting field research expansion knowledge area ultimately improve ability efficiently effectively produce livestock required meet increasing worldwide demand meat products
rapid developments computer technology information technology human machine interfaces aircrafts ships nuclear power plants battlefield command system complex information systems evolved traditional control mode digital control mode visual information interface paper studies error factors information interface human computer interaction based visual cognition theory feasible error cognition model established solve design problems result serious failures information recognition analysis even operation execution processes based rasmussen norman reason error types well hera cream failure identification models performed classification cognitive characterization error factors according information search information recognition information identification information selection judgment well decision making process obtained comprehensive error cognition model complex information interface
background prevalence characteristic determinants anemia time inflammatory bowel disease ibd diagnosis yet fully elucidated methods retrospective cross sectional study analytical data disease characteristics obtained upon diagnosis ibd patients crohn disease ulcerative colitis collected results anemia present patients diagnosis patients respectively reactive protein respectively current smoking risk factor anemia protective one penetrating behavior increased risk anemia anemia increased disease extension conclusions female sex disease activity major determinants anemia ibd diagnosis anemia associated disease behavior disease extension published elsevier ltd behalf editrice gastroenterologica italiana
learning based model predictive control lbmpc new control policy combines statistical learning along control engineering providing levels guarantees safety robustness convergence designed control policy respects general rules flocking static obstacles appear uavs required steer around also avoid collisions also uav team match team members velocity stay close flockmates flight main contribution paper lays solving formation reconfiguration problem group cooperative uavs forming desired formation using lbmpc presence uncertainties obstacles simulation
integrative trend world economy drastic competition market commercial intercourse future emphasize convenience thus strengthening comprehensive transportation network research practice become mainstream paper describes development intelligent traffic control dispatch system
haze weather becoming one biggest problems many big cities china triggers public anxiety official concerns particulate matter plays important role causing adverse health effects chemical composition includes primary particles secondary particles toxicological mechanisms human body include oxidative stress inflammation carcinogenesis short long term exposure especially cause series symptoms including respiratory symptoms cough wheezing dyspnea well symptoms positive associations mortality due number causes considered contribute onset asthma exacerbation chronic obstructive pulmonary disease copd haze weather approaches including outdoor health care indoor health care preventive medications prevent patients chronic airway diseases exacerbations
adaptive intelligent instructional systems used deal issue learning personalisation contexts human instructors immediately available role transferred entirely part onto computer even though systems mostly developed well defined domains rather straightforward acquisition order mathematics computer programming found application ill defined domains well natural language learning one domain developing adaptive instructional systems specific purpose notoriously complex challenging due nature language systems paper hand examines theoretical background adaptivity intelligence instructional systems discusses application learning teaching natural languages moreover paper reviews adaptive intelligent language learning systems existence identifies characteristics systematic manner discussion section offers detailed view selected systems language learning exhibit interesting innovative implementation solutions paper concludes suggesting possible developmental directions future work field
recent experiences indicate already reported types cancer circulating tumor cells ctcs may play role also non small cell lung cancer nsclc diagnosis therapy monitoring prognostic purposes ctcs evaluation could particularly relevant clinical setting objective difficulty obtaining tumor tissue also lack reliable tumor markers current review focus possible applications ctcs nsclc patients elsevier ireland ltd rights reserved
nanotechnology material surface modification provided functional platform advancement several medical fields dermatology furthermore smart choice preparation material proven confer unique properties develbped nanosystems context focused sphingolipid cer amide whose deficiency found negatively affect psoriasis ceramide doped surfactant based vesicular phospholipid systems create tubulated vesicles cerosomes loaded model anti psoriatic drug tazarotene properties tested compared ceramide free vesicles cerosomes characterized drug entrapment viscosity vitro drug release morphology vivo drug skin deposition thermal behavior clinically tested psoriatic patients factorial design study revealed surfactant type ceramide surfactant ratio presence ethanol hydration buffer affected entrapment efficiency viscosity vesicles ceramide increased entrapment tazarotene decreased release enhancing deposition within skin correlating better clinical therapeutic outcome compared topical marketed product ceramide also able cause significant membrane tubulation vesicles causing deviate conventional spherical morphology conclusion cerosomes present new functional treatment modality psoriasis worthy future experimentation elsevier rights reserved
objective pharmacotheraphy recommended smoking cessation clinical practice however cardiovascular safety smoking cessation drugs questioned goal evaluate effects smoking cessation drug varenicline cardiovascular parameters oxidative stress subjects methods twenty six smokers without cardiovascular diseases healthy subjects enrolled study total oxidant status tos total antioxidant status tas urotensin levels determined blood samples echocardiography performed individuals smokers assessed measurements mentioned beginning treatment group end third month group measurements performed control group results aortic strain distensibility measurements group found significantly lower group significant changes observed varenicline treatment tos values group found higher groups differences statistically significant however tas values group found significantly lower group differences groups terms diastolic dysfunction urotensin levels conclusion study revealed varenicline may decrease tas smokers thanks smoking cessation varenicline seem negative effects aortic stiffness studies needed confirm results
atypical femur fracture aff serious complication long term bisphosphonate therapy usually preceded incomplete fracture appearing lateral femur aff likely result severely suppressed bone turnover ssbt however differences bone structure turnover patients incomplete complete aff remain unknown examined trans iliac bone biopsies white postmenopausal women aff incomplete complete therapy years healthy white premenopausal women histomorphometric measurements performed separately cancellous intracortical endosteal envelopes histomorphometric measurements difference bone surfaces cancellous intracortical endosteal bone resorption variables nos endosteal surface significantly lower patients complete aff incomplete aff compared healthy premenopausal women trabecular bone volume thickness number significantly lower patients aff dynamic bone formation variables patients aff significantly reduced bone surfaces likelihood biopsy tetracycline labeling significantly higher aff patients healthy premenopausal women based results conclude significant differences bone turnover patients incomplete complete aff suggesting suppression bone turnover already existed femur incomplete aff compared healthy premenopausal women bone turnover similarly suppressed patients either type aff
computer programming related courses account large proportion current information courses courses typically include language programming language programming java language programming language programming data structures algorithms many common aspects terms knowledge points among programming courses however currently courses taught separately furthermore trend shrinking time allocation declining number courses undergraduate curriculum critical maximize use limited hours programming courses enhance teaching effectiveness based inquiry based teaching model accordance cdio teaching philosophy proposed paper conduct programming curriculum group construction therefore knowledge program design courses within group shared courses instruction within group coordinated knowledge sharing facilitates application experiments projects improve students comprehensive capabilities especially ability solve practical problems
paper presents neutronics conceptual design long life mwth innovative sodium cooled fast reactor isfr isfr derived based korean prototype generation sodium cooled fast reactor pgsfr intended alternative fast reactor option waiting availability readiness fuel recycling technology republic korea isfr core designed lifetime efpys effective full power years average core discharged bumup greater mthm loaded annular metallic low enriched uranium leu fuels arranged eight rings hexagonal assemblies surrounded three rings pbo radial reflectors core neutronic performance characteristics core lifetime power profiles thermal hydraulics analysis kinetics parameters reactivity feedback coefficients cladding fast neutron fluence analyzed using mccard monte carlo code matra lmr thermal hydraulics sub channel code balance reactivity bor analysis also investigated preliminary assess safety capability isfr several unprotected transient scenarios addition two new unique passive safety devices named fast floating absorber safety transient safe static absorber feedback equipment also introduced discussed paper elsevier ltd rights reserved
background substance use pregnancy associated severe maternal fetal morbidities substantial economic costs however studies evaluated cost effectiveness substance use treatment programs pregnant women purpose study evaluate economic impact behavioral intervention integrated motivational enhancement therapy cognitive behavioral therapy met cbt treatment substance use pregnancy comparison brief advice methods conducted economic evaluation alongside clinical trial collecting data resource utilization performing cost minimization analysis met cbt brief advice similar effects clinical outcomes alcohol drug use birth outcomes costs estimated health care system perspective included intervention costs hospital facility costs physician fees costs psychotropic medications date intake assessment month postpartum compared effects met cbt costs brief advice using wilcoxon rank sum tests results although integrated met cbt therapy higher intervention cost brief advice median participant versus participant costs care prenatal period delivery postpartum period well psychotropic medications comparable two groups values statistically significant difference overall cost care median total cost participant met cbt versus participant brief advice conclusions met cbt therapy brief advice resulted similar clinical outcomes overall medical costs research incorporating non medical costs targeting women severe substance use disorders evaluating impact met cbt participants quality life provide additional insights
chlormadinone acetate cma progesterone derivative acetoxy chloro pregnadiene dione first synthesized used progestin based hormone replacement therapy since first used oral contraception combined ethinyl estradiol cma exerts potent progestagenic effect one third higher observed endogenous progesterone cma also anti estrogen showing androgenic effects birth control dose unlike progesterone mild glucosteroidal effect anti mineralocorticoid effect biological actions allowed cma role therapeutic use dysmenorrhea hyperandrogenism contraceptive agent addition cma exhibited beneficial neuroendocrine effects women mood cma combination shown excellent contraceptive efficacy high tolerability compliance due risk benefit profile additional benefits skin hair reduction seborrhea acne metabolic tolerance cma demonstrated several clinical studies currently cma formulated taken oral caplets caplets package containing cma per pill without seven placebo additional pills another presentation caplets containing cma plus four placebo pills
laser stealth space target useful important urgent practice paper introduces definition expression laser radar cross section lrcs general laws influencing factors space target lrcs including surface materials types target shape size paper discusses possible laser stealth methods space target practical applications two view points material stealth methods shape stealth methods conclusions suggestions provide references next research thinking methods target laser stealth
background adolescents cancer enrolled clinical trials far lower rates children report compares number adolescents year olds children year olds enrolled protocols european pediatric soft tissue sarcoma study group epssg number cases expected occur methods observed expected ratio detected epssg countries contributing cases italy france spain netherlands united kingdom ireland observed cases included patients enrolled epssg protocols october october epssg protocols open countries number expected cases calculated incidence rates estimated throughout rarecarenet database countries population based cancer registries results countries considered cases aged years enrolled epssg trials children adolescents ratio among patients years old opposed years old ratio differed different subtypes adolescents rhabdomyosarcoma rms non rhabdomyosarcoma soft tissue sarcomas nrsts respectively children respectively ratios differed across countries considered conclusions adolescents less well represented children epssg protocols better enrolment rms nrsts age groups
application synchronization theory build new cryptosystems hot topic last two decades paper analyze recent proposal field pinpoint main limitations software implementation chaos based systems designed grounds synchronization theory addition show cryptosystem evaluation possesses serious security problems imply clear reduction key space
warming climate anticipated increase future heat related total mortality urban areas however little evidence reported cause specific mortality nonurban areas assessed impact climate change heat related total cause specific mortality urban rural counties jiangsu province china next five decades address potential uncertainty projecting future heat related mortality applied localized urban nonurban specific exposure response functions six population projections including population change scenario five shared socioeconomic pathways ssps temperature projections global scale general circulation models two representative concentration pathways rcps results showed projected warmer temperatures lead higher heat related mortality total non accidental cardiovascular respiratory stroke ischemic heart disease ihd chronic obstructive pulmonary disease copd causes occurring annually may september jiangsu province china nonurban residents jiangsu suffer excess heat related cause specific mortality urban residents variations across climate models rcps dominated uncertainty heat related mortality estimation whereas population size change limited influence findings suggest targeted climate change mitigation adaptation measures taken urban nonurban areas jiangsu province specific public health interventions focused leading causes death stroke ihd copd whose health burden amplified warming climate elsevier ltd rights reserved
paper improved tan phi expansion method proposed seek general exact solutions new partial differential equation concise straightforward method applied biswas milovic equation bme exact particular solutions containing four types hyperbolic function solution trigonometric function solution exponential solution rational solution obtained solutions comparing methods recently method developed searching exact traveling wave solutions nonlinear partial differential equations abundant exact traveling wave solutions including solitons kink periodic rational solutions found solutions might play important role engineering physics fields shown method help symbolic computation provide straightforward powerful mathematical tool solving problems nonlinear optic elsevier gmbh rights reserved
one serious challenges computer vision image classification learning accurate classifier new unlabeled image dataset considering available labeled training data transfer learning domain adaptation two outstanding solutions tackle challenge employing available datasets even significant difference distribution properties transfer knowledge related domain target domain main difference two solutions primary assumption change marginal conditional distributions transfer learning emphasizes problems marginal distribution different conditional distribution domain adaptation deals opposite conditions prior works exploited two learning strategies separately domain shift problem training test sets drawn different distributions paper exploit joint transfer learning domain adaptation cope domain shift problem distribution difference significantly large particularly vision datasets therefore put forward novel transfer learning domain adaptation approach referred visual domain adaptation vda specifically vda reduces joint marginal conditional distributions across domains unsupervised manner label available test set moreover vda constructs condensed domain invariant clusters embedding representation separate various classes alongside domain transfer work employ pseudo target labels refinement iteratively converge final solution employing iterative procedure along novel optimization problem creates robust effective representation adaptation across domains extensive experiments real vision datasets different difficulties verify vda significantly outperform state art methods image classification problem
objective studies facial affect recognition people traumatic brain injury tbi shown significant problem vocal affect recognition also appears challenging population little known degree one modality impaired compared study compared facial vocal affect recognition high low intensity emotion expressions people moderate severe tbi methods diagnostic analysis nonverbal accuracy adult faces voices administered participants tbi results adults tbi identified vocal emotion expressions greater accuracy facial emotion expressions facial affect recognition impairment identified participants classified vocal affect recognition impairment showed impairment modalities participants significantly less accurate identifying low high intensity emotion expressions modalities happy facial expressions significantly better identified emotions errors distributed across emotion categories vocal expressions conclusions degree facial affect impairment significantly greater vocal affect impairment sample people moderate severe tbi low intensity emotion expressions particularly problematic advantage positively valenced facial emotion expressions indicated
objective apremilast oral phosphodiesterase inhibitor downregulates intracellular inflammatory mediator synthesis elevating cyclic adenosine monophosphate levels palace trial evaluated apremilast efficacy safety patients active psoriatic arthritis psa despite prior conventional disease modifying antirheumatic drugs biologic therapy methods eligible patients randomized placebo apremilast bid apremilast bid week patients swollen tender joint count improvement improvement american college rheumatology response criteria acr week results intent treat population acr week achieved patients receiving apremilast bid bid versus placebo clinically meaningful improvements signs symptoms psa physical function psoriasis observed apremilast week common adverse events diarrhea nausea headache upper respiratory tract infection diarrhea nausea generally occurred early usually resolved spontaneously continued treatment laboratory abnormalities infrequent transient conclusion apremilast demonstrated clinical improvements psa weeks including signs symptoms physical function psoriasis new safety signals observed clinicaltrials gov identifier nct
purpose knowledge regarding environmental impacts agricultural systems required consideration uncertainty life cycle assessment lca provides additional scientific information decision making aims study compare environmental impacts different growing cherry tomato cultivation scenarios mediterranean conditions assess uncertainty associated different agricultural production scenarios materials methods burdens associated cherry tomato production calculated evaluated lca methodology functional unit chosen study mass unit commercial loose cherry tomatoes study included quantitative uncertainty analysis monte carlo simulation three scenarios considered greenhouse screenhouse open field flows processes product scenario structured several sections structure auxiliary equipment fertilizers crop management pesticides waste management six midpoint impact categories selected relevance climate change terrestrial acidification marine eutrophication metal depletion fossil depletion using impact evaluation method recipe midpoint ecotoxicity using usetox results discussion structure auxiliary equipment fertilizers produced largest environmental impacts cherry tomato production greatest impact stages found manufacture drawing steel structures manufacture perlite amount hdpe plastics used electricity consumed irrigation system manufacture application fertilizers cropping scenario largest environmental impact categories varying higher respectively metal depletion higher eutrophication showed highest uncertainty ecotoxicity bandwidth ctue probability higher respectively conclusions lca used improve identification evaluation environmental burdens cherry tomato production mediterranean area study demonstrates significance conducting uncertainty analyses comparative lcas used comparative relative product environmental impacts
objective association allergic disease depression consistently reported whether key mediating ingredients predominantly biological psychological mere artifacts remains unknown current study examined hypothesized relationship allergen specific immunoglobulin ige status changes allergy symptoms worsening depression scores methods patients recurrent mood disorders individually coupled sensitization specific seasonal aeroallergens assessed allergen specific ige temporal windows exposure aeroallergens low versus high tree ragweed pollen counts measured according national allergy bureau guidelines compared structured interview guide hamilton depression rating scale seasonal affective disorder version sigh sad depression score changes patients mood disorders major depression bipolar disorder diagnosed structured clinical interview dsm scid seropositive tree ragweed pollen specific ige antibody versus patients mood disorders major depression bipolar disorder seronegative aeroallergen specific ige results worsening total depressive scores low high pollen exposure greater allergen specific ige positive patients compared allergen specific ige antibody negative patients stratified polarity association significant patients bipolar disorder relationship resilient adjustment changes allergy symptom scores conclusion knowledge first report coupling molecular marker vulnerability allergen specific ige specific environmental trigger airborne allergens leading exacerbation depression patients bipolar disorder
examined causal relationship playing violent video games increases aggressiveness using implicit measures aggressiveness become important accurately predicting impulsive behavioral tendencies ninety six adults randomly assigned play one three versions computer game differed regard game content violent peaceful abstract game work reading task games environmental context mouse gestures physiological arousal indicated heart rate skin conductance kept constant violent game soldiers shot peaceful game sunflowers watered abstract game simply required clicking colored triangles five minutes play alter trait aggressiveness yet implicit association test detected change implicit aggressive self concept playing violent game produced significant increase implicit aggressive self concept relative playing peaceful game well controlled study closes gap research causality link violence exposure computer games aggressiveness specific regard implicit measures discuss significance importing recent social cognitive theory aggression research stress need development aggression related implicit measures aggr behav wiley liss inc
paper provides comprehensive review published literatures concerning fluid mechanics heat transfer mechanisms liquid drop impact heated wall review divided four parts centered one main heat transfer regimes film evaporation nucleate boiling transition boiling film boiling regimes discussed detail terms available depictions drop deformation breakup proposed heat transfer mechanisms predictive correlations models shown understanding underlying physics heat transfer regime highly dependent experimental methods investigators adopted broadness available databases terms liquid type drop size momentum impact angle wall material surface roughness despite significant advances experimental theoretical computational research understanding interfacial behavior drop moment impact many inconsistencies concerning important aspects impact process ensuing heat transfer especially regards critical heat flux transition boiling leidenfrost point review concluded recommendations concerning future work needed address poorly understood contradictory issues published elsevier ltd
objective evaluate effects week polestriding intervention gait disease severity people mild moderate parkinson disease design withdrawal study design setting outpatient movement disorder center community facility participants individuals women men mean age range mild moderate according united kingdom brain bank criteria hoehn yahr score ranging stable medication regimen ability tolerate medication state interventions twelve week polestriding intervention week follow main outcome measures gait evaluated using several quantitative temporal spatial variability measures addition disease severity assessed using clinical scales unified parkinson disease rating scale updrs hoehn yahr scale parkinson disease questionnaire results step stride lengths gait speed step time variability improved significantly week polestriding intervention also updrs motor score updrs axial score scores updrs subscales walking balance improved significantly intervention conclusions increased step time variability decreased step stride lengths associated severity increased risk falls observed improvements suggest regular practice polestriding may reduce risk falls improve mobility people american congress rehabilitation medicine
model driven architecture mda one prominent trends software development nowadays approach proven alleviate many problems usually appear software development processes particular possibility automatically translate models executable code reduces bugs development deployment times among important advantages transformation mapping domain abstract models technology independent technology dependent models platform independent models become crucial issues reason business analysis software engineering communities recognize importance business process modelling software development paper proposal process generating validating model transformations using ontologies introduced proposal starts description business processes within organization intended contribute automation quality architectural design
study design retrospective study prospectively collected data objective aim study identify risk factors developing hospital acquired conditions hacs association hacs day complications adult spinal deformity asd population summary background data hacs subject nonpayment policy center medicare medicaid services provide incentive medical institutions improve patient safety hacs asd population may exacerbate already high rates postoperative morbidity mortality methods acs nsqip database queried using current procedural terminology cpt codes adults fusion spinal deformity patients divided two cohorts basis development hac defined case surgical site infection urinary tract infection venous thromboembolism univariate multivariate logistic regression analyses employed determine predictors hacs association hacs day postoperative outcomes results five thousand eight hundred nineteen patients met inclusion criteria study hac multivariate logistic regression analysis revealed age versus years odds ratio versus versus hours hours associated developing hac hacs also risk factors postoperative complications
paper addresses problem voltage regulation power distribution networks deep penetration distributed energy resources renewable based generation storage capable loads plug hybrid electric vehicles cast problem optimization program objective minimize losses network subject constraints bus voltage magnitudes limits active reactive power injections transmission line thermal limits losses provide sufficient conditions optimization problem solved via convex relaxation using data existing networks show sufficient conditions expected satisfied networks also provide efficient distributed algorithm solve problem algorithm adheres communication topology described graph graph describes electrical network topology illustrate operation algorithm including robustness communication link failures several case studies involving bus power distribution systems
opportunistic subcutaneous fungal infections increasing nowadays due growing number medical conditions causing immunosuppression especially organ transplant incidence rate subcutaneous phaeohyphomycosis low studies found case reports showed wide variation clinical presentations pyrenochaeta romeroi fungus dematiaceae group saprophyte found soil plants possible causative agent phaeohyphomycosis present rare case subcutaneous phaeohyphomycosis caused romeroi mimicking synovial cyst diabetic patient
paper novel approach proposed increase confidence active slip system identification polycrystalline metals approach takes advantage microscale deformation tracking via digital image correlation dic combined scanning electron microscopy sem experimentally obtained high resolution deformation fields mapped undeformed configuration gives slip traces suitable comparison undeformed crystal orientation data metric named herein relative displacement ratio rdr calculated displacement fields near slip traces characterize localized deformation due slip validation cases experimentally measured rdrs matched well rdrs theoretically calculated active slip systems test cases active slip system identification incorporating rdr additional constraint demonstrated preferable using schmid factor alone constraint proposed approach supplements existing techniques slip system identification increased confidence
paper presents novel method capturing profile inside rolling road vehicle tyre tyre road contact region method captures contact region times vehicle negotiates obstacles system uses pair inexpensive digital cameras capable capturing frames per second features purely mechanical stabilisation system ensure cameras capture contact region wheel speed vehicle acceleration captured images processed using computer vision techniques using open source computer vision library called opencv stereo image pairs used create clouds points showing profile inside surface good accuracy various obstacles traversed deformed tyre profile compared undeformed profile system improves current measurement techniques used measure contact patch capturing large region contact patch providing full surface geometry well remaining centred contact patch irrespective wheel rotation system also enables imaging techniques used digital image correlation determine velocity profiles well strain measurements istvs published elsevier ltd rights reserved
use saft equation state model solubility various homopolymers also model swelling ratio polypropylene mixture using saft compare results sanchez lacombe simha somcynsky equations results show saft describe solubility polymers well compare two sets parameters saft equation gross chen swelling ratio saft using chen parameters better equation commonly used early researchers studying solubility polymers wiley periodicals inc
students significant behavioral social problems experience poorest outcomes school beyond imperative therefore educational researchers school based professionals address needs students exhibit maladaptive behavior alter poor outcome trajectory social problem solving sps instruction promising approach improving social competence changing problem behaviors despite documented outcomes sps instruction school settings coleman wheeler webber review appears date compilation sps literature thus purpose article present current review literature sps interventions school settings examine summarize studies investigating sps interventions settings discuss findings implications educational research practice
machine vision technologies hold promise enabling rapid accurate fruit crop yield predictions field key fulfilling promise accurate segmentation detection fruit images tree canopies paper proposes two new methods automated counting fruit images mango tree canopies one using texture based dense segmentation one using shape based fruit detection compares use methods relative existing techniques method based nearest neighbour pixel classification contour segmentation method based super pixel segmentation classification using support vector machines robustness algorithm tested multiple sets images mango trees acquired period years image sets acquired varying conditions light exposure distance tree average number fruit tree orchard season images collected conditions calibration images estimated fruit numbers within actual fruit numbers measure detection performance methods results poorer models used estimating fruit numbers trees different canopy shape different imaging conditions used fruit background segmentation nearest neighbour pixel classification based colour smoothness pixel classification based super pixel segmentation clustering dense scale invariant feature transform features visual words bag visual word super pixel classification using support vector machines effective simple contrast colour based segmentation pixel classification best followed fruit detection using elliptical shape model blob detection using colour filtering morphological image processing techniques method results also compared using precision recall plots imaging night artificial illumination careful attention maintaining constant illumination conditions highly recommended
new fault diagnosis method based multi signal flow graph msfg proposed deal online complex system diagnosis method three steps first step develop multi signal graph model object system generate dependency matrix diagnostic knowledge second step generate conflict sets dependency matrix system observation vector problem finding minimal diagnosis set transformed problem integer programming final step optimal solution problem integer programming calculated using branch bound algorithm diagnosis way explosion problem caused enumeration avoided order facilitate application msfg modeling line diagnosis real problems intelligent diagnostic platform idp provides msfg modeling environment employs branch bound algorithm complex system diagnosis developed structure software idp presented finally case study fuel system aircraft described detail illustrate procedure using idp diagnostic problems demonstrate effectiveness proposed method
currently developed methods detect sharp wave transients exist latent phase hypoxia ischemia electroencephalogram eeg order determine micro scale transients potential biomarkers major issue sharp waves eeg possess large variability sharp wave profile making difficult build compact footprint uncertainty fou required ideal performance type fuzzy logic system fls classifier paper develop novel computational eeg analysis method robustly detect sharp waves using post occlusion eeg equivalent utero preterm fetal sheep model cohort demonstrate initial wavelet transform sharp waves stabilizes variation profile thus permits highly compact fou built hence optimizing performance type fls demonstrate method leads higher overall performance clinical sampled eeg high resolution sampled eeg improved upon conventional standard wavelet respectively fuzzy approaches respectively performed isolation
optimal use electrical energy efficiency consumption two important questions today industrial energy management suppliers buy energy power plants transmit customers power consumed input end users thus supplier real impact supplier subject stochastic changes energy utilization limited possibilities control power consumption nevertheless supplier interest keeping power level smooth possible one suppliers compensation tools integration remote controlled heating equipment electrical boilers heaters switched supplier low tariff periods aim project develop reliable methods efficient utilization centralized ripple control system crcs controlled storage water heaters paper summarizes results research optimization power consumption crcs elsevier ltd rights reserved
cancer multifactorial disease network genes causing genetic alterations sophisticated techniques molecular biology revealed different cancer pathway mechanistic approach still shrouded tumor necrosis factor tnf related apoptosis inducing ligand receptors emerged potential target drug cancer therapy among natural products basidiomycete fungus ganoderma lucidum constituents endowed plethora activities modulating signaling cancer ganoderic acid triterpene lanosteroidal skeleton play inextricable role modulating signaling cascades various mitogenic pathways present study receptor based molecular docking performed study dynamic behavior docked complexes molecular interactions ganoderic acid isoforms tumor necrosis factor receptor top scoring compounds compared already documented natural inhibitor tumor necrosis factor curcumin catechin bupropion pentoxyphyllin binding affinity absorption distribution metabolism excretion toxicity properties ganoderic acid interact promising compared isoforms gscore kcal mol lipophilic evdw bond glide emodel involvement tyr leu gln residues binding tumor necrosis factor docking ganoderic acid ganoderic acid exhibits gscore hbond glide emodel involvement hydrogen bonding inmet arg pro glu residues natural inhibitors already documented exhibit low binding energy docking parameters edge ganoderic acid tumor necrosis factor ganoderic acid efficiently inhibits proliferation viability intracellular reactive oxygen species messenger rna expression tumor necrosis factor breast cancer cell lines
understand components behavior urban water cycle useful management environmental economic resources city concept integrates hydrological water supply distribution water use water pollution harvesting treatment reuse bogota rates population geographic growth going accelerated pace point urban water cycle gaining greater importance public private administrations necessary search new sources water supply extension basic sanitation infrastructure control pollutants bogota rivers according paper presents analysis current state components urban water cycle bogota additionally presents different challenges facing city sustainable environmental social economic future
propose novel framework photometric stereo low light conditions using uncalibrated near light illumination operates free form video sequences captured minimalistic affordable setup address issues albedo variations shadowing perspective projections camera noise method uses specular spheres detected perspective correcting hough transform robustly triangulate light positions presence outliers via least squares approach furthermore propose iterative reweighting scheme combination norm minimizer robustly solve calibrated near light problem contrast approaches framework reconstructs depth albedo relative light source intensity normals simultaneously demonstrated synthetic real world scenes
membrane parallel theoretical framework computing homology information foreground background binary digital images developed starting work progress two senses providing advanced topological information homology torsion efficiently answering decision classification problem sum xels related cycle boundary optimizing previous framework implemented using gpgpu computing discrete morse theory effective homology theory parallel computing techniques suitably combined obtaining homological encoding called algebraic minimal model region interest seen cubical complex presegmented digital image elsevier rights reserved
factors promote healthy relationships understudied objective study examine mother child verbal nonverbal communication separately relationship quality children positive social behaviours risk sample framed within developmental psychopathology approach mothers part year longitudinal prospective study children rated peers measures aggression social withdrawal mothers year old children participated conflict game playing tasks verbal nonverbal communication coded separately using systematic observational measures maternal childhood histories aggression withdrawal predicted poorer dyad verbal communication relationship quality children positive social behaviours frequently displayed positive verbal nonverbal communication associated better relationship quality children positive social behaviours results highlight unique contributions verbal nonverbal communication adaptive development promoting healthy relationships risk families middle childhood
objective due time constraints limit physician ability deliver detailed contraception counseling patients increasingly require supplemental education opportunities applications smartphones tablets designed educate patients contraceptive methods simplify communication patient provider designed mobile application entitled plan birth control provide targeted information common nonpermanent contraceptive methods emphasis long acting reversible methods study design developed mobile application designed provide tailored information common nonpermanent contraceptive methods pilot testing volunteers clinic participants recruited randomized controlled trial clinicaltrials gov identifier nct participants assigned simple randomization contraception counseling via tablet health educator compared participants contraceptive choice groups secondary outcomes included knowledge method choice satisfaction counseling results participants primary study chose long acting reversible methods uptake long acting reversible contraceptives similar groups received health educator counseling received mobile application counseling groups demographically similar age educational status knowledge long acting methods differ significantly groups conclusion results study suggest plan birth control adversely affect highly effective birth control uptake study population save time physicians health educators used adjunct contraception counseling waiting room settings
series novel pyrimidine based sulfonamides synthesized short periods time microwave conditions good excellent yield chemical structures heterocycles consist central pyrimidine ring phenyl group pyrimidine groups sulfonamide motifs enzyme inhibitory potential compounds investigated acetylcholinesterase ache butyrylcholinesterase bche enzymes play crucial role treatment alzheimer disease compared reference compound eserine ache bche values synthesized compounds ranged ache bche among tested compounds group found potent one enzymes ache bche quantitative structure activity relationship qsar molecular docking studies synthesized compounds also performed
although extensive research investigated benefits green buildings little known user perception satisfaction studies involving users green buildings form post occupancy evaluations gather satisfaction scores qualitative feedback building occupants however difficult generalize individual case studies wider discussion preferences green building attributes current research uses generalizable technique examine occupants experiences green buildings study identifies relative importance environmental experiential design categories occupants based lived experiences space article provides results choice based conjoint cbc study compares responses green non green building occupants results provide novel insights degree importance experiential categories design social territories visual non visual aesthetics compared environmental categories design energy efficiency water savings indoor environmental quality article contributes green building design literature evaluating green buildings new perspective based users preferences perspective influential developing green building rating systems enhancing green building performance elsevier ltd rights reserved
conventional wisdom aggressive networking requirements high packet rates small messages scale tail latency best addressed outside kernel user level networking stack present dataplane operating system provides high performance high resource efficiency maintaining protection isolation benefits existing kernels uses hardware virtualization separate management scheduling functions kernel control plane network processing dataplane dataplane architecture builds upon native zero copy api optimizes bandwidth latency dedicating hardware threads networking queues dataplane instances processing bounded batches packets completion eliminating coherence traffic andmulticore synchronization control plane dynamically adjusts core allocations voltage frequency settings meet service level objectives demonstrate outperforms linux user space network stack significantly throughput end end latency moreover improves throughput widely deployed key value store xand reduces tail latency three varying load patterns control plane saves processor energy allows background jobs run standalone throughput
applications remote sensing imaging medical imaging high resolution images urgently required image super resolution reconstruction great application prospects optical imaging paper propose novel unified partial differential equation pde based method single image reconstruction firstly two directional diffusion terms calculated anisotropic nonlinear structure tensor anlst constructed combing information channels prevent singular results making full use directional diffusion feature secondly introducing multiple orientations estimation using high order matrix valued tensor instead gradient orientations estimated precisely junctions corners unique descriptor orientations mixed orientation parameter mop separated two orientations finding roots second order polynomial nonlinear part synthesize gradient vector flow gvf shock filter balance edge enhancement noising process experimental results confirm validity method show method enhances image edges restores corners junctions suppresses noise robustness competitive existing methods
one main aims green building movement desire create healthy indoor environment building occupants terms improving enhancing occupant well unique case emerges healthcare facilities whose main existence based principles improving health patients leadership energy environmental design leed rating system become widely recognized used certification system green buildings including green hospital buildings however hospitals high total scores may green buildings necessarily optimal green healthcare environment patient wellbeing perspective goal study identify whether hospitals healthcare facilities actually value specific criteria influence health patients recovery period depth analysis leed healthcare specific credits revealed general tendencies practices green healthcare buildings based statistical analysis mean percent healthcare specific scores calculated certified leed healthcare hospitals certified leed new construction hospitals certified leed new construction rating systems hospitals included healthcare category initially expected successful ones terms achieving patient recovery wellbeing related credits proved earn lowest percent relevant points analysis result may attributed heightened restrictions requirements credits healthcare scorecard hospitals may valuing level certification credits deemed relevant patient wellbeing rate recovery either due lack information due economic constraints high correlation coefficient calculated among total scores healthcare specific scores healthcare dataset hand correlation coefficients calculated two datasets indicate random pattern among two variables hospitals certified new construction rating system seem weak support claim hospitals receive high total scores thus certification levels high healthcare specific points well
recent quantum private set intersection qpsi scheme cryptanalyzed original claimed communication overhead shown accurate original security definition passive fair ensure fairness passive third party introduced also shown unconditional fairness qpsi protocol impossible since otherwise would violate well known impossible quantum cryptography result
decision making project delivery system pds important link entire lifecycle project one critical factors leading project success traditionally pdss usually chosen based decision makers experience knowledge project information without exploring inherent dependencies influencing factors pdss presently researches factors affecting choice pdss primarily concentrated owner characteristics project characteristics project external environment paper mainly aimed owner characteristics researched key factors affecting decision making pdss two aspects studied subsequent research twenty two influencing factors owner characteristics summarized literature review relatively important high frequency factors high frequency chosen discussion specialists based owner characteristics information chinese construction projects collected questionnaires taken research sample rough set method applied reduce redundant factors result indicates responsibility owner willingness involved owner house technical capability risk allocation owner willingness control overdesign owner five key characteristics factors affecting pdss decision making research result provides valuable reference owner choosing appropriate pdss enriches research methods field pdss although design build design bid build dbb engineering procurement construction epc deeply studied research reported paper pdss turnkey construction management project management would taken consideration researches
design high stability voltage controlled current source vccs cervical cancer detection ccd applying electrical bio impedance spectroscopy ebs presented circuit designed simulated tsmc cmos technology power supply proposed howland current source based self biased complementary folded cascode cfc operational amplifier complying requirements medical electrical equipment international standard abnt nbr iec sinusoidal current peak amplitude settled accordance requirements ebs ccd specifications cfc calculated meet mhz frequency range sinusoidal output current output impedance higher omega mhz frequency post layout simulations run main results output current peak amplitude specified frequency range omega load impedance values omega output impedance mhz nominal current amplitude variations lower load impedances range omega omega results performance vccs adequate ebs ccd applications
paper presents study collective knowledge information technology comparative analyses innovative trends standardisation roads knowledge subfields software engineering focus amount required innovation necessary examples database standardised units improvement information systems goal determine obtain appropriate knowledge model excellence contribution modelling excellence pdca plan check act presented elsevier rights reserved
purpose reviewsuicide attempts usually regretted people survive furthermore addiction gambling represented among people attempt die suicide raising question whether decision making impaired advances decision neuroscience enabled investigate decision processes suicidal people elucidate putative neural substrates disadvantageous decision making recent findingsearly studies linked attempted suicide poor performance gambling tasks recently functional mri augmented reinforcement learning computational model revealed impaired decision making suicide attempters paralleled disrupted expected value expected reward signals ventromedial prefrontal cortex behavioral studies linked increased delay discounting low lethality poorly planned attempts multiple attempts occurrence attempted suicide addiction behavioral tendency may related altered integrity basal ganglia contrast well planned serious suicide attempts associated intact diminished delay discounting one study linked high lethality suicide attempts impaired social decision making summarythis emerging literature supports notion various impairments decision making often broadly related impulsivity may mark different pathways suicide propose aggressive self destructive responses social stressors people prone suicide result predominance automatic pavlovian processes goal directed computations
objective assess patient physician discordance global assessment disease activity early axial spondyloarthritis axspa time determinants discordance methods desir devenir des spondyloarthropathies indifferenciees recentes french multicentre longitudinal cohort patients early inflammatory back pain suggestive axspa patient global assessment pga physician global assessment phga rated numerical rating scale every months years years discordance defined absolute difference pga phga range analysed visit determinants pga phga assessed visit level generalised linear mixed model results total patients analysed baseline complete data years mean age years female mean symptom duration months mean pga values always higher mean phga values mean absolute difference points baseline patients discordance mainly pga phga years frequency discordance stable range discordance stable patient level patients discordant twice twice determinants pga phga spine pain fatigue conclusions discordance concerned quarter patients early axspa years follow discordance decrease reference shift discordance stable trait indicating discordance patient characteristic
selecting right technology given application critical future enterprise companies invest billions dollars year new technologies intended provide competitive advantage many attempts rationalize technology selection process sufficiently focused technology many processes simply add layer complexity already difficult process developed three stage technology selection tool provides framework simple risk managed process evaluating selecting new technologies tool provides powerful visual aid help clarify key attributes various technologies decisions related adoption illustrating team members senior management decision making processes engaged technologists project managers considering new technologies three stage filter tested new product development project leading multinational company seeking smart material technologies drive strategic innovation
wireless sensor network applications range industrial automation control agricultural environmental protection surveillance medicine applications data highly sensitive must protected type attack abuse security challenges wireless sensor networks mainly defined power computing resources sensor devices memory size quality radio channels susceptibility physical capture article embedded sensor node microcontroller designed support sensor network applications severe security demands presented features low power bitprocessor core supported number hardware accelerators designed perform complex operations required advanced crypto algorithms microcontroller integrates embedded flash channel bit analog digital converter making good solution low power sensor nodes article discusses important security topics wireless sensor networks presents architecture proposed hardware solution furthermore gives details chip implementation verification hardware evaluation finally chip power dissipation performance figures estimated analyzed
relationship hydroxyvitamin parathyroid hormone pth metabolic traits appear differ among ethnicities may influenced obesity aim study examine association serum pth metabolic syndrome mets controlling adiposity black women using cross sectional study design urban black women aged years north west province south africa included multiple regression models used explore relationship pth body composition explore association pth mets separate variable created including least mets criteria excluding elevated waist circumference diagnostic criterion logistic regression model majority women overweight obese women excessive adiposity using age specific cut points body fat percentage body composition variables positively associated pth whereas body mass index waist circumference body fat percentage negative associations also adjusting confounders adjusting age body fat habitual physical activity tobacco use season data collection estimated glomerular filtration rate neither pth showed significant associations mets although pth positively associated negatively associated adiposity black women association either pth mets study population adiposity influence relationships
framework presented investigating antenna coupling arbitrary environments way antenna environment scattering parameter matrices environment scattering parameter matrices bona fide scattering parameters describe environment radiation ports terminated nonreflecting loads simplification antenna coupling equations leads second formulation compatible classically defined antenna scattering parameter matrices third formulation based auxiliary set matrices describing environment scattering unexcited radiation ports open circuited extends coupling formulation used spherical near field antenna measurements arbitrary environments
prior studies demonstrated price transparency lowers test ordering rates trainees hospitals physician targeted price transparency efforts viewed promising cost controlling strategy examine effect displaying paid price information test ordering rates common imaging studies procedures within accountable care organization aco block randomized controlled trial year total fully licensed clinicians primary care specialists starting january clinicians control arm received price display intervention arms received single paired internal external median prices test ordering screen electronic health record internal prices amounts paid insurers aco services external paid prices amounts paid insurers services delivered unaffiliated providers ordering rates orders per face face encounters adult patients overall designated completed internally within aco considered inappropriate mri simple headache thought appropriate screening colonoscopy found significant difference overall ordering rates across control single median price paired internal external median prices study arms every encounters clinicians control arm ordered tests single median price arm ordered tests paired prices arms ordered tests one way anova value difference ordering rates tests designated completed internally considered inappropriate appropriate displaying paid price information alter frequently primary care specialist clinicians ordered imaging studies procedures within aco particular interest removing waste health care system may want consider variety contextual factors affect physician targeted price transparency
italy since early english word gender twisted code word purported teoria gender gender theory ideologia gender gender ideology also simply referred gender gender theory purportedly aims destroy differences males females preaching sex sexual orientation gender identity gender roles chosen children ought indoctrinated schools knowledge paper examines roots concept originating within opus dei evolved france movement equal rights sex couples gender ideology understood either philosophical theological theory mere political tool utterly confused theories gender movement fact coherent rebuttal gender studies queer theories rather concocted mishmash conspiracy theories held true far right groups
past research shown activation aggressive cognitions memory media violence exposure examined priming effects viewing relational aggression media current study women viewed video clip depicting physical aggression relational aggression aggression subsequent activation physical relational aggression cognitions measured using emotional stroop task results indicated priming relational aggression cognitions viewing relationally aggressive video clip activation physical relational aggression cognitions viewing physically aggressive video clip results discussed within framework general aggression model aggr behav wiley periodicals inc
stressful environment families mothers depressive symptoms might increase children risks developing behavioral problems exacerbating genetic influences using data nationally representative early childhood longitudinal study birth cohort data approximately pairs twins examined whether genetic influences preschoolers behavioral problems depended upon mothers depressive symptoms results indicated genetic etiology internalizing externalizing behaviors varied maternal depressive symptoms months child age genetic effects externalizing behaviors increased mothers depressive symptoms increased however genetics effects internalizing behaviors increased depressive symptoms either increased decreased median level different patterns interactive effects suggest potentially different mechanisms etiology children externalizing internalizing behaviors
new application aqueous based post combustion combined capture process proposed simultaneously capture remove sulfite solid kso precipitation method thermodynamic model kso system combined capture process developed validated work analyze heat absorption system kso precipitation characteristics kso system average heat absorption system degrees around mol loading average heat absorption system degrees around mol loading average heat absorption system degrees mol loading loading respectively solubility kso increases temperature loadings decreases concentration loaded aqueous thermodynamic evaluation indicates combined capture process could employ typical absorption regeneration process simultaneously capture absorber thermally desorb stripper feasibly remove sulfite oxidized sulfate content precipitating kso lean solvent lean rich heat exchanger elsevier ltd rights reserved
objective treatment options psoriatic arthritis psa increased improved past decade treatment patterns psa remain poorly understood understanding current practices would aid treatment management patients psa methods observational study based data corrona registry adult patients psa north america collected january december patients divided among therapy cohorts tumor necrosis factor inhibitor tnfi monotherapy methotrexate mtx monotherapy tnfi mtx combination therapy patients divided among study periods understand changes time data collected persistence discontinuation restarting switching adding dropping therapy dose stretching results study included patients tnfi monotherapy mtx monotherapy combination therapy time proportion patients initiating tnfi monotherapy decreased proportion initiating combination therapy remained constant percentage patients persistent decreased time across therapy cohorts remained higher tnfi monotherapy cohorts duration persistence decreased time patients initiating mtx monotherapy likely tnfi counterparts add therapy conclusion treatment patterns patients psa changed physicians likely initiate tnfi monotherapy although clinical evidence supporting effectiveness increased study period patients remain persistent
typical variable air volume vav terminals spend majority time minimum airflow set points often higher minimum ventilation requirements defined code resulting excess energy use risk cooling spaces developed tested time averaged ventilation tav control strategy institutional building berkeley campus address issue whenever zone require cooling tav alternates vav damper partially open fully closed average airflow matches predefined ventilation setpoint compared existing base case scenario using single max vav logic strategy reduced mean zone airflow fraction intervention period corresponding reductions average heating cooling fan power respectively addition programmed directly native control system tav may applied via smap low cost retrofit strategy building bacnet network direct digital control ddc vav terminal elsevier rights reserved
viable therapy curing type diabetes mellitus pancreatic islet transplantation however unavoidable terms immunogenicity differently affected transplantation site therefore necessary determine alternate sites permit successful islet transplantation outcomes paper reviews evidence anterior chamber eye ace could good site islet transplantation compared alternate sites addition site may promising technical platform noninvasive vivo imaging transplanted pancreatic islets korean society industrial engineering chemistry published elsevier rights reserved
three dimensional carbon materials derived waste biomass attracted increasing attention catalysis materials science great potential catalyst supports respect multi functionality unique structures high surface area low cost present facile efficient way preparing heterogeneous catalysts based vertical mno wires deposited hemp derived porous carbon porous carbon materials fabricated carbonization activation processes using hemp cannabis sttiva porous carbon materials employed catalyst supports direct deposition vertical mno wires using one step hydrothermal method xrd xps results reveal crystalline structure alpha mno wires resultant composites employed catalyst glycolysis poly ethylene terephthalate pet high conversion yield expected expressly profitable plastics recycling industry elsevier rights reserved
considering major requirements automotive applications high torque power density low torque ripple wide speed range high speed operation capability synchronous reluctance machine still intensive investigation traction motor proper operation synrm low high speeds desired magnetic mechanical performance core structure important challenges therefore prior final design need analyzed regards core magnetic behavior mechanical robustness cause degradation torque quality harmful deformation critical points rotor structure low speed high current demand maximum torque makes core magnetic performance dominant whereas high speed mechanical behavior rotor core structure limits machine performance paper presents comparative analysis different core characteristics improve core magnetic mechanical performance synrm equipped transversal laminated anisotropic rotor type automotive applications
research chinese film industry far behind actual development practice especially considering evolution main influential factors furthermore existing research film industry economic geography mostly conducted perspective cluster theory lesser attention institutions culture paper theory evolution used tackle two gaps role institutions culture industrial organization three fundamental elements evolution pointed discussed theoretical section phenomena evolution shanghai film industry important examples chinese film industry analysed empirical part phase development process four periods differentiate identified effects evolution institutions culture industrial organization based specific setting particular period
present study examined levels construal affect retrieval induced forgetting higher level construal associated focus similarities among stimuli suggesting high level construal promotes relational processing based fact retrieval induced forgetting may reduced eliminated high level construal condition effect relational processing two experiments conducted using retrieval practice paradigm different stimuli priming level construal meta analysis synthesizing results showed retrieval induced forgetting occurred low level construal condition whereas forgetting occur high level construal condition results suggest abstract thinking eliminate retrieval induced forgetting relational processing demonstrating role levels construal memory inhibition
proportion elderly people years old rapidly increased social costs related aging population problems grown globally governments want reduce social costs advanced technologies physician medical center evaluates health conditions reports elderly people however self reports often inaccurate sometimes reports family caregivers accurate solve problems evaluated objective method based sensor data needed paper propose data driven smart home system uses web technologies connecting sensors actuators proposed system provides method monitoring elderly people daily activities using commercial sensors register recognizable activities easily addition controls actuators home using user defined rules shows summary elderly people activities monitor
radar cross section rcs measurement setup characterization measurement periodic structures presented idea modify existing spherical range anechoic chamber setup allowing scattered field measurements pec artificial magnetic conductor prototypes proposed setup scattered field object test measured different azimuth roll angles well incident wave polarization measurement setup performance validated comparing simulations measurements finally combined pec artificial magnetic conductor surface intended rcs reduction measured proposed setup
nowadays obesity seriously increasing populations world associated development progression high mortality diseases type diabetes mellitus tdm subsequent cardiovascular pathologies recent data suggest body fat distribution adipocyte phenotype determinant fatal outcomes obese patients increased general adiposity particular visceral adiposity significantly linked long term alterations different cardiac structures developed forms myocardial diseases hypertensive ischaemic heart diseases diabetic cardiomyopathy interestingly depot may also related epicardial fat accumulation secretion lipids adipokines pro inflammatory oxidative factors adipocytes thus visceral adiposity white single lipid like adipocytes risk factors different forms heart disease heart failure mainly higher degree obese subjects however specific stimuli adipocytes transdifferentiate brown multi mitochondrial like adipocytes anti inflammatory anti apoptotic proprieties accordingly order improve potential cardiovascular abnormalities obese tdm patients several therapeutic strategies addressed modulate visceral epicardial fat volume phenotypes addition lifestyle modifications specific genetic manipulations adipose tissue administration ppar agonists statins improved fat volume phenotype cardiovascular failures furthermore incretin stimulation reduced visceral epicardial fat thickness whereas increased formation brown adipocytes alleviating insulin resistance associated cardiovascular pathologies
widespread ideas muslim women oriented life home participating paid labour article explores notions work groups practicing muslim veiled turkish dutch students higher education netherlands turkish veiled higher education students turkey best prepared group women future paid work primary objective article see respondents think futures regard paid work views compared drawing depth interviews analysed using grounded theory article shows respondents settings keen interest taking paid work also raising families however ideas work differ two settings turkish dutch faced rather gendered expectations local community paid work perceived along gendered lines taking account one roles wife mother choices profession rather gender specific however turkish respondents encounter gendered discourses marriage homemaking strongly choices profession less gender specific rather choose professions regarding perceptions much money would make article shows different discourses regarding gender roles work shape think paid work differently two settings
article examines formalization rainwater harvesting rwh implications new policy trends water governance analysis rwh policies across united states indicates three trends codification water administrative rather public law institutionalization rwh market based tools rise policies different spatial scales resulting greater institutional complexity new bureaucratic actors potential points friction drawing cases colorado texas article argues states diverse legal traditions water enable successful regulatory environments downspout alternatives
paper presents new variable speed wind energy conversion systems wecs based six phase asymmetrical squirrel cage induction generator scig matrix converter power electronic interface six phase scig electrical network analysis employs rotor flux vector control algorithm scalar strategy modulated control generator characteristics used maximizing power tracking control different wind speeds delivering powers grid simultaneously considered provides sinusoidal input output voltages unity power factor causes asymmetry generator current control strategy including method suppressing imbalance caused asymmetry discussed numerical simulations carried showing effectiveness proposed wecs topology
vigorous spread renewable energy much attention paid natural ventilation natural ventilator usually classified passive type active type iri study venturi type ventilator one passive type basically operated bernoulli principle experimentally investigated evaluate ventilation characteristics according outdoor wind velocities opening area wall confirmed experimental results ventilation rate venturi type ventilator linearly increased ventilation rate affected intake opening area wider intake opening size gets ventilation rate increases furthermore new coefficient reflects pressure loss intake opening mixing zone venturi type ventilator introduced experimentally evaluated value beta evaluated provides simple calculation means estimate ventilation rate venturi type ventilator geometric dimensions known elsevier rights reserved
research investigated relevance four hydrological variables performance domestic rainwater harvesting drwh system hydrological variables investigated average annual rainfall precipitation concentration degree pcd antecedent dry weather period adwp ratio dry days rainy days principal component analyses used group water saving efficiency select set variables relevance hydrological variables water saving efficiency system studied using canonical correlation analysis associated pcd adwp attained better correlation water saving efficiency single conclude empirical models represent large combinations roof surface areas rainwater tank sizes water demands rainfall regimes also consider variable precipitation temporal variability treat independent variable elsevier rights reserved
tutorials code puzzles commonly used today novice programming environments introduce computer programming children research explored effectiveness instructional format teaching different kinds information independently little work explored learners perceptions value strategic decisions users make around instructional format learning program present study learners selected set tutorials puzzles identical set programming content explore reasoning behind choices potential implications learning support available future programming environments
order understand security level organization network detection methods important tackle probable risks attackers malicious activities intrusion detection systems detection solutions defense depth concept one main devices record analyze suspicious behaviors besides benefits systems security enhancement bring challenges issues security administrators large number raw alerts generated intrusion detection systems clearly reflect need novel proactive alert correlation framework reduce redundant alerts correlate security incidents discover model multi step attack scenarios track several alert correlation frameworks proposed literature majority address alert correlation offline settings paper propose three phase alert correlation framework processes generated alerts real time correlates alerts aid causal knowledge discovery automatically extract causal relationships alerts constructs attack scenarios using bayesian network concept predicts next goal attacks using creating attack prediction rules experimental results show scalable proposed framework efficient enough learning detecting known unknown multi step attack scenarios without using predefined knowledge results also show proposed framework perfectly estimates complex attacks damage assets network john wiley sons ltd
objective although majority women serious mental illnesses smi mothers limited research available relationship maternal smi pediatric health care use adherence preventive care associated improved children health well also decreased costs health care system study examines relationship maternal psychotic disorders pds pediatric health care method retrospective secondary analysis medicaid claims compares age cohorts children years mothers without pds bivariate multivariate logistic regression models used examine established measures pediatric preventive care emergency department care among mother child dyads results adherence preventive care guidelines ranged among mothers pds among mothers without pds mothers pds times likely least one preventive care visit year times less likely least one visit year significantly likely high reliance children ages years conclusions differences existed pediatric health care use among medicaid insured mothers without pds although preventive pediatric health care use among mothers pds comparable mothers without pds mothers mental illness could still benefit targeted strategies reduce reliance young children years social work involvement families living poverty help families access use preventive care young children
sexism variety prejudice widely addressed severe social problem society owing quality establishing various forms inequality however sexism rather neglected issue geography especially concerning global south postcolonial island state mauritius agrarian oriented socially conservative well integrated global value chains shows unique combination strong paternalistic form inward ethnic orientation characteristic postcolonial states combined minor tendency metropolisation makes island state worthwhile development generic theories sexism general paper analyses relevant predictors sexism mauritius useful informing approaches focus especially north south differences gender inequality becomes apparent mechanisms sexism mauritius dimensions mechanisms found global north communalism absent metropolisation remain significant yet important predictors sex life satisfaction withholding citizen rights foreign wives mauritian men xenophobic attitudes results point direction necessity think new ways attitudinal differences societies global north south especially postcolonial contexts elsevier ltd rights reserved
rationale senegal prevalence childhood asthma utilization appropriate asthma therapies unknown methodology used international study asthma allergies childhood isaac survey instrument assess childhood respiratory health rural senegal interviewed caregivers children aged years age four largest niakhar villages august results interviewed primary caregivers children representing age eligible children study area overall children wheeze time past wheeze within past year reported clinical diagnosis asthma among children wheeze within past year symptoms severe asthma nocturnal cough reported children denied history wheezing illness four children wheeze past year ever received bronchodilator therapy children wheeze past year significantly likely seek medical care respiratory symptoms perceived less healthy peers children lower socioeconomic status significantly likely wheeze conclusions nearly one ten children niakhar senegal symptoms suggestive asthma however children diagnosis asthma use appropriate therapies study highlights opportunity raise community awareness asthma rural senegal increase access appropriate medical therapies wiley periodicals inc
femoral nerve block fnb proposed pain control following anterior cruciate ligament acl reconstruction although numerous studies assessed efficacy fnbs little research effect blocks postoperative strength patient reported outcomes hypothesized performance fnb would result decreased quadriceps strength poorer patient reported outcome scores within first months following acl reconstruction total patients scheduled undergo hamstring autograft acl reconstruction following acute acl injury randomized single shot fnb group control group preoperatively patients completed knee injury osteoarthritis outcome score koos isokinetic quadriceps strength testing degrees second weeks postoperative patients completed koos isometric quadriceps strength testing degrees months postoperative patients completed koos isokinetic strength testing quadriceps femoris strength limb symmetry indices lsi calculated time points repeated measures analysis variance anova models utilized model effect fnb time lsi well koos subscales activities daily living pain symptoms lsi koos subscales demonstrated improvement time following acl reconstruction repeated measures anova demonstrated patients underwent fnb mean lsi lower control group poorer koos symptoms subscale scores point difference weeks postoperative compared controls months postoperative differences noted lsi koos subscales based block status fnb resulted decreased strength poorer koos symptom subscale score weeks following acl reconstruction compared controls differences resolved months postoperative long term effect delayed quadriceps recovery movement patterns functional outcome remains unknown requires study study randomized controlled trial level evidence
one critical aspects drilling operation reduce nonproductive time avoid borehole instability issues kicks blow outs lost circulation stuck pipe breakouts investigate problems one understand formation properties fluid hydraulics basic mechanics behind drilling well previous research field factors widely discussed results obtained related formation properties however considering stresses wellbore mechanical factors rpm contact casing different positions wellbore usually neglected furtherance study importance thermal condition fluid loss filter cake formation study ruled work includes new insight toward understanding stress redistribution due pipe contact wellbore smear mechanism additionally presents numerical analysis influence casing contact downhole thermal conditions using finite element analysis classical equations used obtain wellbore stresses include parameters far field stresses pore pressure wellbore geometry consider influence casing contact drilling mud cake permeability elastic inelastic properties formation take account effects parameters finite element analysis carried considering mentioned parameters various scenarios main objective simulations investigate hypothesis increase hoop stress considering casing contact regard formation stresses orientation study different cases shows variation hundred psi hoop stress however thermal effect near wellbore stress regions important drilling deep water complex drilling environments see thermal effect study develops thermo poroelastic model found decrease radial stress hoop stress near wellbore region time reduction considerable impact fracture initiation pressure near wellbore region also smearing effect influenced stress changes due change temperature
aim presented study assess fractal dimension geometrical characteristics length width landslides identified north tehran iran first landslide locations landslides identified interpretation aerial photographs satellite images field surveys calculate fractal dimension used computer programming named fracek next step geometrical characteristics landslide length width calculated arcgis software landslide polygons digitized mentioned landslide inventory map rotated based movement direction fractal dimension landslides varied subsequently relationship length width ratios fractal values landslides calculated results showed correlation coefficients different regression models exponential linear logarithmic polynomial power ratio relatively high respectively concluded fractal dimension values geometry characteristics landslides would useful indices management hazardous areas susceptible slopes land use planning landslide hazard mitigation
adaptive educational hypermedia systems aehs provided new perspectives access information enhance learning however aehs advantages positive impact learning still defies design production paper propose agile learning design method support design production aehs based agile practices software engineering practices learning design illustrate approach experiment validates proposed method application design aehs called ald aehs creation one important component aehs user model
digital dollhouse proposed enhanced traditional psychological play therapy digital sensors computer graphics combined together obtains significant difference reaction children compared normal dollhouse proposed approach connecting concrete object touching haptic touching information humans several sensors presents several representative image display virtual assume haptic virtual approach would specific effect improving biological reaction children also adult try conducted experiments proposed device method implemented preliminarily experimental obtained knowledge effect haptic virtual approach
flash floods considered catastrophic phenomena possessing major hazardous threat coastal cities towns villages infrastructures study deals evaluation flash flood hazard ungauged wadi lith basin depending detailed morphometric characteristics lith basin sub basins detailed study aster data used preparing digital elevation model dem geographical information system gis used evaluation linear areal relief aspects morphometric parameters major parameters watershed boundary flow accumulation flow direction flow length stream ordering prepared using archydro tool surface tool arcgis software aster dem used create different thematic maps dem contour slope aspect hill shade maps twenty five morphometric parameters measured calculated interlinked produce nine effective parameters evaluation flash flood hazard degree study area based nine morphometric parameters affect hydrologic behaviour wadi influence time concentration direct influence flooding prone area flash flood hazard lith basin sub basins identified classified three groups high medium low hazard degree study provides details flash flood prone area wadi lith mitigation measures study also helps plan rainwater harvesting watershed management flash flood alert zones
acculturative family distancing afd rating questionnaire measures distancing occurs immigrant parents children caused breakdowns communication cultural value differences items included afd questionnaire indicators proximal problem focused aspects acculturation gap study psychometric analysis performed data gathered afd instrument one hundred twenty three chinese american families mothers fathers children total completed questionnaire addition specifications extended tier item factor analysis model within bayesian multidimensional item response theory framework provided psychometrically analyze afd data results suggest original dimensions communication difficulties cultural values incongruency refined clinically relevant dimensions verbal communication difficulties nonverbal communication difficulties general cultural values incongruency family values incongruency moreover reducing number items improve afd estimates reduce assessment burden
model based development become industry wide standard paradigm open source alternative scilab xcos widely employed hybrid dynamic systems modeling tool increasing efficiency implementation using graphical model development code generation modeling simulation community struggling assuring quality well maintainability extendibility refactoring defined evolutionary modernization activity time structure artifact changed alter quality characteristics keeping behavior unchanged widely established technique textual programming languages improve code structure quality refactoring also regarded one key practices model engineering methodologies approaches model refactoring still development architecture driven modernization adm introduced software engineering community model based approach software modernization implicit information lies software artifacts extracted models model transformations applied modernization tasks regarding refactoring low level modernization task practices adm adaptable accordingly paper proposes model based approach model refactoring order come efficient effective model refactoring methodology accessible extendable modelers like graphical modeling tools scilab xcos also possesses formalized model specification conforming implicit metamodel rather proposing another metamodel knowledge extraction pragmatic approach proposes conduct place model model transformations refactoring employing scilab xcos model specification construct structured model based approach implicit scilab xcos metamodel explicitly presented utilizing ecore meta metamodel practical model transformation approach established based scilab scripting scilab toolset provided modeler place model model transformations using sample case study demonstrated proposed model transformation functions scilab provide valuable refactoring tool
sources effects gendered leadership stereotypes women representation explore role stereotypes shaping public attitudes toward women representation using americasbarometer survey data countries report three key results first modal respondent almost every country rejects gendered leadership stereotypes affirming women men leaders equally qualified corruption economy holds even attempt account social desirability bias second significant individual country level determinants stereotyping countries higher women representation labor force participation without gender quotas citizens likely choose pro female neutral responses pro male stereotypes individual level rejecting stereotypes less authoritarian supportive labor market equality leftist reporting pro female stereotypes third consequences representation vary partisanship country context pro female leadership stereotypes boost support women presidential candidates legislative gender quotas matter less among copartisans women candidates matter women candidates viable gendered outsiders rejecting leadership stereotypes altogether less supportive quotas
current trends engine design indicate necessity take advantage highest sates heat transfer associated nucleate boiling mostly high engine loads used conjunction advanced thermal management strategies subcooled boiling may take place low velocities little information available ducts small cross sectional area undesired effects relative sizes ducts bubbles may appear paper experiments subcooled boiling flow low velocities engine like temperature conditions conducted usual engine coolant high speed photographic camera used collect images detached vapor bubbles microscopic characteristics heating surface determined experimental results mean values show acceptable agreement results mechanistic radius model assuming departure lift radius related flow boiling suppression factor additionally results obtained compatible sizes nucleation sites estimated surface characterization results obtained size distribution consistent found literature
objective despite number studies reasons self injurious behavior sib yet clearly specified using path analysis sought test hypothesis exposure adverse events produces depression posttraumatic stress turn motivate dissociation high levels supports use sib method sample adults female mean age years recruited general population national survey company administered measures evaluating posttraumatic stress depression dissociation sib results total participants reported level sib within prior months younger age exposure adverse events posttraumatic stress depression dissociation related sib univariate analyses path analyses revealed although adverse events predicted posttraumatic stress depression associated sib paths sib longer significant dissociation entered model indicating full mediation conclusion rather arising directly posttraumatic stress depression sib may occur proximally response dissociation pain associated sib potentially serving interrupt titrate unwanted hypoarousal numbing clinicians consider specifically targeting dissociation adversity related antecedents treating sib
researchers identified problems validity software engineering research findings particular often impossible reproduce data analyses due lack raw data sufficient summary statistics undefined analysis procedures aim paper raise awareness problems caused unreproducible research software engineering discuss concept reproducible research mechanism address problems idea outcome research paper computational environment report recent studies cast doubts reliability research outcomes software engineering discuss use means addressing problems discuss use software engineering research present methodology used adopt principles report small working example create reproducible research summarise advantages problems adopting methods conclude supports good scientific practice would help address problems found empirical software engineering research
objectives hypothesischildren obstructive sleep apnea osa may multiple sites upper airway obstruction uao wide variety techniques used evaluate uao aim compare findings cine magnetic resonance imaging mri drug induced sleep endoscopy dise identifying uao sites children persistent osa adenotonsillectomy study designretrospective chart review material methodsthe medical records children underwent dise cine mri reviewed data pertaining demographics past medical history body mass index polysomnography findings dise cine mri obtained resultsfifteen children boys girls age range years identified comorbid conditions syndrome nine patients cerebral palsy one attention deficit hyperactivity disorder two asthma three severity osa moderate five severe dise cine mri showed uao site patients single site tongue nine multiple sites tongue oropharynx lateral walls one dise showed additional uao sites undetected cine mri three patients cine mri showed additional uao sites undetected dise one patient dise cine mri showed different sites obstruction one patient conclusionscine mri dise documented single multiple sites uao children persistent osa cine mri dise findings similar majority children assessment sensitivity specificity cine mri dise detecting sites uao merits investigation level evidence laryngoscope
studies war exposed children investigated comprehensive array resilience promoting factors representative samples children adolescents representative sample adolescents randomly selected communities recently exposed war experienced war trauma administered questionnaires measuring war exposure family violence availability leisure activities school related problems interpersonal peer problems socialization daily routine problems displacement availability parental supervision contact medical needs well coping skills related religious coping denial self control avoidance problem solving mental health measured strengths difficulties questionnaire sdq child revised impact events scale cries resilient adolescents defined experienced war trauma manifest symptoms sdq cries resilience related male using problem solving techniques leisure activities parents spent time adolescents supported school work interventions designed war traumatized youth must build individual coping skills children adolescents yet time target parents teachers integrated manner
objective evaluate corticosteroid related quality care indicators patients ulcerative colitis crohn disease methods adults diagnosed prescription fills oral identified large commercial claims database quality indicators included prolonged use days use sparing therapy bone loss assessment state level variations quality care indicators estimated using logistic regression models adjusting age gender insurance plan type severity results patients receiving respectively prolonged users among prolonged users patients used sparing therapy bone loss assessment observed patients prolonged use newly diagnosed patients prolonged use lowest kentucky odds ratio highest wisconsin patients lowest north carolina new york highest utah patients sparing therapy use lowest delaware highest michigan patients significantly different south carolina patients bone loss assessment rates highest arizona patients lowest mississippi highest texas patients limitations information disease severity available database conclusions significant regional variations three quality indicators observed across
contents colostrum milk complex mammary secretions providing puppy many nutritional immunological factors play crucial role correct development survival case colostrum milk intake deficiency puppies increased risk infectious diseases work reviews various nutritional hyperimmune supplementations proposed provide passive immune protection positively impact puppies health strategies rely canine immunoglobulins canine colostrum banking canine serum plasma supplementation others involve heterologous sources antibodies immune factors bovine colostrum hyperimmune egg powder among different solutions evaluated birth weaning canine plasma hyperimmune egg powder showed promising beneficial effect puppies health canine plasma seems positively impact growth increased growth neonatal period also digestive health higher species richness intestinal microbiota general health tendency lower morbidity puppies supplemented hyperimmune egg powder presented increased neonatal growth decreased risk canine parvovirus infection nevertheless natural canine maternal colostrum milk ingestion remains optimal guarantee puppies health survival source immunity energy growth factors
project presents new approach humanoid operated mobile platform using humanoid robot nao aldebaran robotics nao chosen versatility wide range movements allows perform various tasks steering simple programming algorithm system integration nao mobile platform done using arduino microcontroller interface project consists several parts paper focuses implementation developed control system integration new mobile platform improvement previous research integrate hokuyo urg laser range finder navigation system shows good result platform able avoid obstacles navigating conduct obstacle avoidance experiment result shows new platform suitable fit nao handling navigation authors published elsevier
skull fracture characteristics associated loading conditions impact point impact velocity could provide indication abuse accident induced head injuries however correlations fracture characteristics loading conditions infant toddler ill understood simplified computational model representing infant head built simulate skull responses blunt impacts fractures decided first principal strain based element elimination strategy simulation results qualitatively compared test data porcine heads simplified model well captured fracture pattern initial fracture position direction fracture propagation model also well described fracture characteristics found studies human infant cadaveric specimens series parametric studies conducted results indicated parameters studied substantial effects fracture patterns additionally jagged shapes sutures associated strain concentrations skull
last three decades scientists uncovered extent human impacts earth operating systems increasing clarity precision findings prompted scientific claims transitioned holocene anthropocene epoch earth geological history crutzen stoermer time traditional humanist underpinnings university eroded ongoing digitisation massification decentralisation higher education article argues higher education crucial role play responding anthropocene thesis time provides powerful impetus reimagining university posthumanist concepts developing analysis conceptual distinctions drawn visions hope disaster local regional dwelling construction emplacement displacement context university learning environments learning environment specifically addressed throughout fluid transitional space experimenting concepts practices operate outside humanist constructs disciplinary boundaries idea university campus threatens become anachronism author concludes speculative proposition reimagining university anthropocene era
identifying processes human cultures spread across diffferent populations one topical objectives shared among diffferent fields study seminal works analyzed variety data attempted determine whether empirically observed patterns result demic cultural difffusion special issue collects articles exploring several themes modes cultural transmission drivers dispersal mechanisms contexts neolithic europe spread computer programming languages offfer new insights augment theoretical empirical basis study demic cultural difffusion introduction outline state art modeling processes briefly discuss pros cons two commonly used frameworks equation based models agent based models summarize significance article special issue
automated assessment systems gaining popularity within computer programming courses paper perform empirical evaluation mooshak online judge verifies program correctness order determine usefulness classroom settings particular provide detailed study students use tool analyze opinions critiques measure features like capability reduce dropout rates experience carried within course algorithm design analysis collected information several questionnaires data generated tool course among main findings highlight usage tool adequate relation students testing feedback needs richer order improve acceptance among students statistical evidence claim mooshak reduced dropout rate elsevier ltd rights reserved
development transdermal nanocarrier drug delivery system potential treatment psychiatric disorders schizophrenia bipolar disorder described lipid nanocarriers encompassing various solid liquid lipid compositions formulated assessed potential nanosystems transdermal delivery olanzapine previously optimized method hot high pressure homogenization hph adopted production comprised solid lipid nanoparticles sln nanostructured lipid carriers nlc nanoemulsions precirol selected solid lipid progression studies sln exhibited best performance transdermal delivery olanzapine based vitro release permeation studies coupled results physicochemical characterization several solid liquid lipid formulations stability tests performed give indication long term storage behavior formulations good agreement previous studies best choice solid liquid lipid ratio overall findings highlight sln based formulation promising inclusion production transdermal patches representing innovative therapeutic approach
studied effects female migrants acculturation strategies affective evaluation sexism social dominance orientation sdo france host country romania home country quasi experimental design used countries description integrated assimilated separated marginalized female migrant introduced participants benevolent hostile sexism sdo degree acceptance migrant assessed control condition introduced assessing attitudes without migrant description france female migrant perceived positively integration condition three ones assimilation increased sdo romania female migrant perceived positively benevolent sexism lower home culture maintained considering female migrants strategies depend acculturation policies host countries results highlight role integration policies improving female migrants acceptation relations communities relations genders study contributes extant literature two main innovations provides information influence female migrants acculturation strategies gender relations sdo documents influence host home country using similar procedure
paper adaptive fuzzy controller design methodology via multiobjective particle swarm optimization mopso based robust stability criterion proposed plant controlled modeled input output experimental data considering takagi sugeno fuzzy narx model using fuzzy means clustering algorithm antecedent parameters estimation weighted recursive least squares wrls algorithm consequent parameters estimation adaptation mechanism mopso problem online tuning fuzzy model based digital pid controller parameters based gain phase margins specifications formulated experimental results adaptive fuzzy digital pid control thermal plant time varying delay presented illustrate efficiency applicability proposed methodology
background studies examined acute injuries track field elite subelite athletes purpose observe absolute number relative rates injury track field athletes across wide range competition levels ages years penn relays carnival assist future medical coverage planning injury prevention strategies study design descriptive epidemiology study methods year period injuries treated medical staff recorded standardized injury report form absolute number injuries relative injury rates number injuries per competing athletes determined odds ratios ors injury rates calculated sexes competition levels events injuries also broken major minor medical orthopaedic injuries results throughout study period competing athletes participated penn relays carnival injuries sustained medical coverage purposes relative rate injury subtypes greatest minor orthopaedic injuries injuries per participants followed minor medical injuries injuries per participants major medical injuries injuries per participants major orthopaedic injuries injuries per participants college elite athletes displayed lowest relative injury rate injuries per participants significantly less high school injuries per participants masters athletes injuries per participants male athletes displayed greater likelihood minor orthopaedic injury compared female athletes less likely sustain major medical injury heavily participated events relay displayed greatest relative injury rate injuries per participants compared relays conclusion medical coverage teams future large scale track field events need plan least major orthopaedic major medical injuries per participants male track field athletes particularly masters male athletes greater risk injury compared sexes competition levels
across series studies investigated cultural differences children responses ostracism situations working children farmers herders focused painful children estimate ostracism study showed year old children socially interdependent farming community estimated ostracism less painful children independent herding community study showed cultural difference specific social pain apply physical pain study replicated results study showed individual differences parents level social interdependence mediated relationship cultural group painful children estimate ostracism study replicated effect showed children tendency recommend seeking social support following ostracism mediated relationship cultural group perceived pain excluded finally study investigated cultural differences moral responses ostracism showed children farming community punished individual ostracized someone else less harshly children independent herding community thus different economic cultures associated striking differences social interdependence responses ostracism early development
new method obtain second order reductions ordinary differential equations polynomial derivatives dependent variable presented method applied obtain reductions new solutions several well known equations mathematical physics lubrication equation thin film equation zoomeron equation family order partial differential equations includes caudrey dodd gibbon sawada kotera kaup kupershmidt ito lax equations pieces computer algebra code derive reductions also included elsevier inc rights reserved
background bushen tianjing recipe btr traditional chinese herbal medicine prescribed premature ovarian failure pof decades china nevertheless little known regarding underlying molecular mechanism present study investigated effects btr tripterygium glycoside induced pof rat model methods three doses btr administered via intragastric gavage adult female sprague dawley rats induced pof days treatment estrous cycle examined vaginal smear analysis serum levels estradiol follicle stimulating hormone progesterone testosterone measured radioimmunoassay histological analysis assessment apoptosis performed hematoxylin eosin staining ovarian tissue sections expression vascular endothelial growth factor vegf vascular endothelial growth factor receptor vegfr anti apoptotic factor bcl pro apoptotic factors bax caspase ovaries animals examined immunohistochemistry process results btr reverted abnormal estrous cycle decreased ovary index pof rats also improved abnormal secretion reproductive hormones associated pof addition treatment btr protect ovaries induced damage induce intraovarian expression vegf vegfr regulate intraovarian expression apoptosis related proteins conclusions results show btr effective treatment induced pof rats promotion angiogenesis anti apoptosis likely contribute effects btr pof
aging unavoidable phenomenon often afflicting structure functionality body marked onset age associated manifestations parkinson disease second common form dementia manifested lewy body formation dopaminergic dysfunction present study explores silymarin known hepatoprotective regimen efficacy aging using caenorhabditis elegans silymarin positively modulated longevity reduced oxidative stress independent feeding behaviour regulation longevity stress related genes daf sod gst skn indicate possible involvement genes regulating longevity addition silymarin alleviated symptoms reducing alpha synuclein levels lipid accumulation enhanced dopamine function silymarin executes beneficial effects mitigation free radicals achieving alleviation parkinsonism possibly pdr mediated recruitment ubiquitin proteasome system evident qpcr studies altogether silymarin emerged potent molecule investigation aging age related disorders elsevier ltd rights reserved
using signal flow graph approach general synthesis method realisation high order voltage transfer functions presented current conveyor filter obtained resulting filter contains minimum number capacitors resistors well current conveyors plus type operate current mode
simple object access protocol soap among techniques implements web services soap offers lightweight simple mechanism exchange structured typed information among computing devices decentralized distributed computing environment however soap transmits data extensible markup language xml format xml documents huge size verbose thus becoming major hindrance performance high performance applications process lots data paper develop implement evaluate soap performance optimization aggregated architecture disadvantaged network mbps bandwidth aggregated architecture entailed client side caching document literal web services description language wsdl description simple database queries server side gzip compression technique experimental results showed relatively high turnaround time low network throughput nevertheless improved performance soap evident terms bandwidth utilization transfer time useful disadvantaged networks
recent years water pollution become major problem environment human health due industrial effluents discharged water bodies day day new molecules pesticides dyes pharmaceutical drugs detected water bodies bio refractory microorganisms last two decades scientists tried different advanced oxidation processes aops fenton photocatalytic hydrodynamic acoustic cavitation processes etc mineralize complex molecules among processes hydrodynamic cavitation emerged new energy efficient technology treatment various bio refractory pollutants present aqueous effluent review various geometrical operating parameters process discussed emphasizing effect importance parameters designing reactor advantages combining oxidants aops ozone fenton process photocatalytic process discussed recommendation large scale operation observed geometry device operating parameters operating pressure cavitation number key design parameters ultimately decide efficacy potentiality degrading bio refractory pollutants industrial scale
aimto identify nurses role experiences keeping children safe backgroundapproaches preventing identifying responding child abuse neglect moved towards multidisciplinary approach professionals expected contribute goal keeping children safe frequently contact children families nurses well positioned contribute keeping children safe abuse neglect much published around nurses experiences role keeping children safe literature yet synthesized determine challenges potential scope role designintegrative review following integrative review framework data sourcesstudies identified search electronic databases cinahl medline web science scopus informit identify literature published review methodsall studies critically appraised methodological quality using critical skills appraisal programme data study extracted categorized according review aims study major findings resultsinclusion criteria met studies three main findings identified including nurses insufficient knowledge need validation improved communication balancing surveillance support vulnerable families conclusionsnurses many roles experiences keeping children safe often felt knowledge skills support take action area research needed understand nurses feel inadequate disempowered advocate intervene behalf children risk abuse neglect
izmit bay suspension bridge app east istanbul crosses sea samara main span foundation bridge poses interesting challenges bridge site highly seismic region moreover ground profile ranges dolomitic limestone thick sandwich silty sand clay layers overlying bedrock
pathogenesis coronary artery disease cad multi factorial several conventional risk factors ascribed ldl one important risk factor however indian population studies established cad often show ldl levels within normal range patients proven cad hypothesized small dense low density lipoprotein sdldl atherogenic might correlate strongly occurrence severity cad aim study evaluate association serum small dense ldl level angiographically documented coronary artery disease cross sectional case control study sdldl measured patients cad patients without cad total cholesterol hdl cholesterol ldl cholesterol triglycerides measured standard methods along traditional risk factors direct quantitative measurement sdldl done enzymatic analysis mean sdldl level higher patients coronary stenosis patients without coronary stenosis respectively significant correlation mean sdldl severity cad assessed syntax score mean sdldl level low intermediate high syntax score respectively value cut value associated presence cad using roc curve conclusion indian patients established cad higher sdldl levels compared individuals without cad despite comparable ldl levels
contribution studies usability aquifer thermal energy storage ates seasonal solar heat storage means thermo hydraulic modeling geological setting refers north east german basin negb specifically site approx west berlin germany considered storage formation located jurassic sandstones depth surface showing situ undisturbed formation temperature around degrees appropriate hydraulic storage properties paper considers idealised doublet systems faulted well unfaulted reservoir domains studies energy mass transport simulated ates systems five perennial loading unloading series solar thermal energy investigated assumed harvested hectare sized flat plate collector field modeled employing climate data considered region simulation results exemplarily show storage system develops temperature conserving recovery fractions heat recovery first years operation elsevier ltd rights reserved
study explores using passive microwave pmw rainfall estimation spatial temporal adjustment precipitation estimation remotely sensed information using artificial neural networks cloud classification system persiann ccs persiann ccs algorithm collects information infrared images estimate rainfall persiann ccs one algorithms used integrated multisatellite retrievals gpm global precipitation mission estimation time period pmw rainfall estimations limited available continued improvement persiann ccs support integrated multisatellite retrievals gpm current well retrospective estimations global precipitation study takes advantage high spatial temporal resolution geo based persiann ccs estimation effective lower sample frequency pmw estimation probability matching method pmm used adjust rainfall distribution geo based persiann ccs toward pmw rainfall estimation results show significant improvement global persiann ccs rainfall estimation obtained
paper vibration analysis tapered magnetostrictive plate msp studied first time magnetostrictive material msm component smart material due magneto mechanical coupling stress strain relations reciprocal nature feedback control system utilized order investigate magnetic field intensity using velocity feedback gain parameter thickness rectangular msp varies linearly directions first order shear deformation theory fsdt considering shear correction factor used derive governing equations tapered msp including five equations five unknowns solved differential quadrature method dqm results indicate effect various parameters aspect ratio thickness ratio taper ratios controller effect velocity feedback gain frequency msp results also compared available literature findings used vibration cancellation systems utilized designing magnetostrictive actuator motor transducer sensors
aims type diabetes mellitus tdm characterized severe autoimmune destruction pancreatic beta cells triggering autoimmunity beta cells probably caused combination environmental genetic risk factors even though much known genetic tdm information needed completely unravel tangled disease micrornas mirnas class small noncoding rnas molecules negatively regulate gene expression inducing target mrna cleavage inhibiting protein translation abnormal mirna expressions described autoimmune diseases tdm polymorphisms genes codifying mirnas may alter expression corresponding mirna thus confer susceptibility given disease therefore aim study investigate whether polymorphisms genes encoding mir mir mir associated tdm methods frequencies mirna mirna mirna polymorphisms analyzed tdm patients nondiabetic subjects results mir mir polymorphisms associated protection tdm strongest association observed dominant model odds ratio respectively adjustment age ethnicity risk hla loci however mir frequencies differ cases controls conclusion mir mir polymorphisms associated protection tdm
hydropower plants important source renewable energy near future high head storage hydropower plants gain importance key element large scale electricity production systems however power plants cause hydropeaking characterized intense unnatural discharge fluctuations downstream river reaches consequences environmental conditions sections diverse include changes hydrology hydraulics sediment regime short time scales altered conditions affect river ecosystems biota instance due drift stranding fishes invertebrates several structural operational measures exist mitigate hydropeaking adverse effects ecosystems estimating predicting ecological benefit remains challenging developed conceptual framework support ecological evaluation hydropeaking mitigation measures based current mitigation projects switzerland scientific literature refined framework international panel hydropeaking experts framework based set indicators covers hydrological phases hydropeaking important affected abiotic biotic processes effects mitigation measures indicators predicted quantitatively using prediction tools discharge scenarios numerical habitat models framework allows comparison hydropeaking effects among alternative mitigation measures pre mitigation situation reference river sections identified key issues addressed increase efficiency current future projects include spatial temporal context mitigation projects interactions river morphology hydropeaking effects role appropriate monitoring evaluate success mitigation projects elsevier rights reserved
online role playing video games provide opportunities connect socially enhance self esteem players however overuse fosters dependency leading negative psychosocial health consequences per american psychiatric association criteria diagnosis internet gaming disorder igd follow addiction model include characteristics preoccupation tolerance withdrawal though useful approach lacks focus underlying motivations may partially explain vulnerability igd study explored relationships among igd symptoms two potential risk factors social phobia player avatar identification participants female recruited game related internet forums surveyed online tested model positive relationship social phobia igd symptoms partially mediated stronger avatar identification social phobia avatar identification igd symptoms strongly positively related found modest support mediation proposed accordingly suggest fundamental needs social connection approval potent motivators play particularly socially phobic players uncomfortable face face contact vicarious interactions gaming avatar may fulfill needs reinforcing stronger self identification avatar turn offer players stronger positive sense self influences may work synergistically motivate increasing intensity preoccupation gameplay contributing igd results support use player avatar identification assessing risk igd developing treatment options reaching better understanding socialization identity influenced virtual interactions accomplishments elsevier ltd rights reserved
biogas earmarked efficient way promote economic development mitigate environmental emissions requires better accounting framework evaluate performance study aim develop emergy based accounting framework assess report sustainability performance biogas projects first existing financial accounting environmental accounting methodologies combined measure report economic events environmental characteristics biogas project using new metric emdollar value cost revenue flows within system boundary unified quantified multiplying specific emergy transformity reflect embodiment hierarchical characteristics integrated accounting framework covering economic aspects economic profitability economic efficiency operation risk environmental aspects environmental resource utilization load emissions environmental economic composited characteristics emissions reduction efficiency emdollar intensity emission reduction emission intensity profit set accordingly results show biogas project positive net present value emdollars total cost returned years renewability ratio environmental load ratio elr composite sustainability indicator csi reflecting environmental load respectively proposed sustainability accounting framework may unveil real environmental support assess ecological economic performance biogas project elsevier ltd rights reserved
handy system presented creating real time natural television image composed real scene computer graphics object light positions colors rgb values real scene estimated applied object using simple equipment objective subjective experiments demonstrated effectiveness system enhanced algorithm also presented improves accuracy light estimation
evaluating smiles people regarding amusement authenticity spontaneity intensity perceivers typically rely orbicularis oculi activity causes wrinkles around target eyes called duchenne marker also impact generalized judgments person characteristics regarding target attractiveness intelligence dominance trustworthiness address issue current study asked participants provide smile evaluations person judgments series duchenne non duchenne smiles results showed smile evaluations uniformly increased duchenne marker presence marker effect person judgments contrast judgment dependent attractiveness dominance intelligence ratings showed expected enhancement trustworthiness ratings remained unaffected facial cue interest findings suggest duchenne marker role cue social relevance target perception depends type person inference consideration
background key challenge human nutrition assessment usual food intake particular interest given recent proposals ehealth personalized interventions adoption mobile phones created opportunity assessing improving nutrient intake used digitalizing dietary assessments providing feedback last years hundreds nutrition related mobile apps launched installed millions users objective study aims analyze main features popular nutrition apps compare strategies technologies dietary assessment user feedback methods apps selected two largest online stores popular mobile operating systems google play store android itunes app store ios based popularity measured number installs reviews keywords used search follows calorie diet diet tracker dietician dietitian eating fit fitness food food diary food tracker health lose weight nutrition nutritionist weight weight loss weight management weight watcher calculator inclusion criteria follows english language minimum number installs million google play store reviews itunes app store relation nutrition diet monitoring recommendation independence device wearable subscription results total apps classified popular inclusion analysis nine apps offered prospective recording food intake using food diary feature food selection available via text search barcode scanner technologies portion size selection textual without images icons nine apps also capable collecting physical activity information using self report global positioning system gps wearable integrations outputs focused predominantly energy balance dietary intake none nine apps offered features directly related diet plans motivational coaching contrast remaining four apps focused opportunities without food diaries one app fatsecret also innovative feature connecting users health professionals another health provided nutrient balance score conclusions high number installs indicates clear interest opportunity diet monitoring recommendation using mobile apps apps collecting dietary intake used nutrition assessment method food diary record technologies data input text search barcode scanner emerging technologies image recognition natural language processing artificial intelligence identified none apps decision engine capable providing personalized diet advice
prevalence antisocial behavior school settings still discouraging students often engage aggressive acts may lack ability appreciate emotional consequences behaviors share others emotions children empathic attitudes questionnaire ceaq one questionnaires used assess empathy children early adolescents study aimed validate spanish version ceaq sample comprised children males aged years madrid confirmatory factor analysis indicated excellent fit unidimensional model chi cfi rmsea multigroup invariance analysis showed significant gender related differences levels results also referred acceptable reliability omega results provide psychometric support use spanish version ceaq valid reliable instrument assess empathy children youth population especially school based interventions
ulipristal acetate upa new selective progesterone receptor modulator used emergency contraception however understanding mechanisms action oviductal cilia limited present study focused vitro effects upa mol cilia steroid receptors human fallopian tubes ciliary beat frequency cbf ultrastructure cilia levels steroid receptors measured effects upa progesterone induced cbf reduction also studied results show upa dose dependently antagonizes progesterone induced cbf decrease affect cbf ultrastructure cilia upa also upregulates expression levels estrogen receptor fallopian tubes results enable better understand mechanisms upa works emergency contraceptive provides scientific basis clinical application
paper provide exploration analysis lean six sigma lss implementation dutch manufacturing engineering small medium sized enterprises smes critical success factors csfs impeding factors identified analysed exploratory empirical evidence lss implementation dutch smes collected survey study dutch smes statistical testing applied validate ranking csfs deepen insight organizations translate csfs practice cope impeding factors additional depth qualitative information gathered six case studies linking customer vision plan statement communication management involvement participation highest ranked csfs internal resistance availability resources changing business focus lack leadership strongest impeding factors case studies confirmed importance csfs revealed three new csfs personal lss experience top management development project leader soft skills supply chain focus smes netherlands make distinct separation lean manufacturing six sigma rather apply approaches intertwined journal operational research society doi jors published online may
paper presents extension palladio component model pcm together new performance analysis infrastructure supports fixed priority preemptive scheduling policy proposed solution allows modelling analysing component based embedded software applications defined using specific pattern component executed task specific priority infrastructure also capable analysing system performance tasks access shared resources using either immediate priority ceiling priority inheritance protocols order avoid priority inversion problem paper shows set rules enable transformation application compliant proposed design pattern corresponding pcm finally use case example based real system set tests validates analysis infrastructure provided system board software satellite payload currently developed space research group university alcala software charge managing instrument control unit energetic particle detector launched part solar orbiter mission european space agency united states national aeronautics space administration nasa elsevier inc rights reserved
paper innovative method presented identify models modified frequency domain subspace method new approach allows introduce subspace resolution constraints identified model poles location general formulation proposed take account regions continuous discrete map formulation based lmi linear matrix inequalities description stability domain represents particular case lmi constraints combined frequency domain subspace resolution obtain identified models whose poles situated specified lmi regions approach benchmarked loewner one belongs class frequency domain input output model identification approximation methods besides fact belong data driven model approximation class result slightly different objectives show complementary performances discussion illustrated practice experimentations performed identification control gust disturbance wing span sub transonic wind tunnel facility
developmental lead exposure suggested laboratory studies trigger neurodegenerative diseases alzheimer disease sortilin related receptor dlr class repeats containing sorl recently identified genetic risk factor sorl limited characterization vertebrate models comparison genetic risk factors characterize sorl protein sequence homology humans mice zebrafish analyzed showed conservation functional repeats domain orientation next spatial expression sorl zebrafish larvae completed diffuse expression neural tissue restricted brain observed influences sex age quantitative expression sorl brain adult zebrafish assessed sex specific alteration sorl expression transpired aging process females zebrafish utilized investigate impacts ppb embryonic exposure sorl expression known genetic risk factors sex specific quantitative gene expression analysis completed adult zebrafish brain compare developmentally exposed control treatment significant difference sorl expression genetic risk factors observed overall study provided characterization sorl changes brain expression aging female specific finding agreement females prone onset analysis additional genetic risk factors needed facilitate understanding impact ppb embryonic exposure copyright john wiley sons ltd
context coordinating software project across distances challenging even without geographical time zone distances distances within project cause communication gaps example organisational cognitive distances product owners development near roles developers testers lead differences understanding interpretation business requirements applying good software development practices known enhance alignment coordination within development projects alleviate challenges objective aim research identify describe underlying factors explain certain practices support aligning coordinating software development projects method inductively generated theory analysing empirical data consisting interviews different companies systematic iterative analysis based initial hypothesis distances affect development results previous research results present theory distances explains practices improve communication within project impacting distances people activities artefacts also present theoretical model specific alignment practices affect different types distances conclusions results provide basis research used software organisations improve software practice elsevier rights reserved
evidence support role cerebellum emotional learning processes demonstrably altered patients chronic pain tested cerebellar activation altered visceral pain related fear conditioning extinction irritable bowel syndrome ibs cerebellar blood oxygenation level dependent bold data ibs patients healthy controls collected part previous fmri study reanalyzed utilizing advanced normalizing method cerebellum differential fear conditioning paradigm consisted acquisition extinction reinstatement phases acquisition two visual conditioned stimuli presented either paired unpaired painful rectal distension unconditioned stimulus extinction phase presented without reinstatement unpaired presentations followed unpaired presentations group differences cerebellar activation analyzed contrasts acquisition ibs patients revealed significantly enhanced cerebellar bold responses pain predictive safety cues compared controls pcs group differences prominent contrast extinction reinstatement significant group differences found visceral pain related fear conditioning ibs patients showed increased activations circumscribed areas medial intermediate lateral cerebellum areas involved autonomic somatosensory cognitive functions likely contribute different aspects pain related fear cerebellum contributes altered pain related fear learning ibs
aim determine prevalence symptoms eating disorders overweight obesity population students city bom jesus methods epidemiological cross sectional study used self administered questionnaire assessment eating disorders body image dissatisfaction bullying kidscape gender age number daily meals total body mass height also collected study results study found individuals symptoms eating disorders overweight obese excess body fat associated symptoms eating disorders victims bullying almost times likely overweight individuals performed meals showed less likely overweight conclusions results similar cities country world showing need preventive measures
wind turbine drivetrains consist components directly convert kinetic energy wind electrical energy therefore guaranteeing robust reliable drivetrain designs important minimize turbine downtime current drivetrain models often lack ability model impacts electrical transients well wind turbulence shear one package work capability fast wind turbine computer aided engineering tool developed national renewable energy laboratory enhanced integration dynamic model drivetrain dynamic drivetrain model built using simscape matlab simulink environment incorporates detailed electrical generator models model used future test advanced control schemes extend life gearbox
scope predictive adaptive response hypothesis suggests utero environment mismatched post natal environment influence later life health underlying mechanisms poorly understood may involve gene transcription changes regulated via epigenetic mechanisms methods results factorial design female cbl mice randomised low normal folate diets folic acid diet prior pregnancy lactation offspring randomised high low fat diets weaning genome wide gene expression promoter dna methylation measured using microarrays adult male livers maternal folate depletion high fat intake post weaning influenced gene expression genes respectively promoter dna methylation loci respectively changes expression methylation poorly matched dietary interventions expression genes altered response maternal folate depletion post weaning high fat feeding treatments imposed separately addition evidence combined dietary insult maternal folate depletion followed high fat post weaning caused largest expression change genes conclusion observations align provide evidence support potential underlying mechanism predictive adaptive response hypothesis
blasting important essential prerequisite opencast mine fragmenting hard deposits blasting always produces unwanted effects like ground vibrations noise fly rock among ground vibrations effect surrounding structures propagation ground vibrations lead destruction surrounding structures prediction ground vibrations especially terms peak particle velocity beneficial opposed conventional data monitoring techniques expensive well time consuming paper uses predictors estimate intensity ground vibrations compares different methods prediction methods like linear regression multiple linear regression non linear regression nlr artificial neural networks intensity ground vibrations generated blasting operations monitored three different mines limestone dolomite coal obtaining ground vibration recordings total statistical modelling data driven modeling shown promise prediction blast vibrations proposed system introducing site specific rock parameters like poison ratio uniaxial compressive strength rock young modulus improve correlation coefficient using statistical modelling commonly called feature engineering machine learning circles
chronic kidney disease ckd common costly health problem middle east incidence ckd still unknown incidence end stage renal disease esrd estimated incident cases per million population middle east countries available statistics prevalence treated esrd published population based studies incidence prevalence ckd esrd still lacking middle east countries negatively affects health planning effectiveness preventive therapeutic measures region prevalence renal replacement therapy vanes among different countries middle east infrastructure services also variable among countries affects outcome yet measured accurately low gross national income middle east countries major factor negating implementation research planning improvement services ckd patients overcome obstacles renal services middle east countries constraints health expenditure need surmounted easy task related appropriately gross national income awareness within medical community public large advances therapeutic preventive measures also important factor progress toward better kidney health middle east
paper presented novel approach low energy consumption architecture box used advanced encryption standard aes algorithm using programmable second order reversible cellular automata rca architecture entails low power implementation minimal delay overhead performance proposed rca based box terms security evaluated using cryptographic properties nonlinearity correlation immunity bias strict avalanche criteria entropy also found proposed architecture secure enough cryptographic applications moreover proposed aes algorithm architecture simulation studies show energy consumption power dissipation mhz energy consumption power dissipation mhz proposed aes algorithm rca based box shows reduction power consumption energy consumption compared best classical box composite field arithmetic based aes algorithm apart also shown rca based boxes dynamic nature invertible low power dissipation compared lut based box hence suitable wireless body area network wban applications
structural failures occur worldwide various investigations concluded primary causes failure design construction errors within building process however exact factors played significant role clear therefore primary focus study improve structural safety determining influencing factors structural safety within design construction process first theoretical framework developed based safety science management literature particular concept critical success factors factors within projects essential reach stated goals appeared useful research factors mentioned literature played role within documented structural failures netherlands based framework questionnaire established questionnaire participants building industry asked indicate extent factors theoretical framework present successful less successful projects addition asked select greatest determining factors structural safety opinion list possible factors results statistically analyzed factors concerning interrelations various project partners largest impact structural safety communication collaboration control mechanisms allocation responsibilities structural risk management safety culture knowledge infrastructure factors designated critical factors structural safety essential assure structural safety within projects
transient faults safety critical computer based systems represent major issue guaranteeing correct system behaviour fault injection commonly used method evaluate sensitivity systems paper presents fault injection tool called kito evaluate effects faults memory containing data structures belonging unix based operating system particular elements linked resource synchronization management experimental analysis conducted large set memory elements operating system system subject stress benchmark programs use different elements linux kernel experimental results show synchronization aspects kernel susceptible significant set possible errors ranging performance degradation failure successfully completing benchmark application elsevier ltd rights reserved
purpose rapport service employees customers suggested important determinant customer relationship management yet existing marketing literature still lacks sufficient understanding service employees nonverbal communication affects customer employee rapport development service encounters purpose paper fill research gap proposing testing model explores service employees nonverbal communication employee affective delivery behavioral mimicry influences customer positive emotions customer employee rapport mediating role customer positive emotions moderating role store atmosphere process customer employee rapport development also assessed design methodology approach using observational methodology conjunction customer survey multi source survey data collected customer employee pairs apparel retailing industry examined structural equation modeling regression analysis findings results showed employee nonverbal communication positively influenced customer positive emotions customer employee rapport partial mediating role customer positive emotions moderating role store atmosphere process rapport development also confirmed practical implications service firms train motivate employees use nonverbal communication develop strengthen customer employee rapport importance customer positive emotions service process addressed customer employee rapport development process moreover service managers also allocate firm resources create well designed store atmosphere target customers originality value research represents one earliest studies explore empirically test influence employee nonverbal communication customer employee rapport development service encounters partial mediating role customer positive emotions moderating role store atmosphere relationship employee nonverbal communication customer employee rapport also proposed confirmed
background atopic dermatitis inflammatory disease skin characterised chronic relapsing course aim aim study assign prevalence clinically active food allergies among group children months years age methods eighty eight children screened specific ige antibodies food proteins patients specific ige antibodies food proteins subjected oral food challenges ofcs relevant foods results food sensitised patients moderate levels sige clinically active food allergy milk egg basis positive ofcs high ige eosinophilia prevalence almost regardless concomitant food sensitisation disease severity conclusions study clinically active food allergies recognised children nevertheless association confirmed food sensitisation severity high ige peripheral eosinophilia found prevalent among children severe among children food sensitisation infants younger children screened underlying food allergy regardless disease severity seicap published elsevier espana rights reserved
acne vulgaris common skin diseases people experience lives thirteen rhizosphere isolates screened propionibacterium acnes bacterium exhibited highest activity acnes identified bacillus methylotrophicus yml rrna gene sequencing scanning electron microscopy used assess changes morphology acnes preliminary studies antimicrobial substance demonstrated hydrophilic nature compound mic mbc cytotoxic effect extract least survival compared benzyperoxide survival results suggest yml promising bioresource may useful lead bacterium develop new type anti acne skin care prep cure prevent acne mechanism action proper clinical trials may promising research
background aim irritable bowel syndrome ibs common functional gastrointestinal disorder commonly diagnosed one gastroenterologists study aim explore frequency ibs among medical students qassim factors associated disorder among materials methods cross sectional study carried among medical students academic levels three local universities qassim region qassim university unizah well alrajhi colleges medicine data study collected throughout semester academic year using validated self administered anonymous paper questionnaire questionnaire included three main sections demographics rome iii criteria hospital anxiety depression scale hads results among students completed study ibs senior medical students times likely ibs juniors depression significantly associated ibs stepwise logistic regression showed chronic health problems advanced academic level personal history ibs significant predictors ibs conclusion prevalence ibs among medical students qassim region depression age living situation advanced academic years family personal history episode travellers diarrhoea main predictors ibs offering psychological emotional support along stress management courses order deal stress recommended
control wave energy converters wecs often limited hydrodynamic control absorb maximum energy possible ocean waves generally ignores significantly simplifies performance real power take pto systems however including required dynamics constraints control problem may considerably vary control strategy power output therefore paper considers incorporation model conversion stages ocean waves electricity network referred wave wire models identifies necessary components dynamics constraints including grid constraints addition paper identifies different control inputs different components pto system inputs articulated dynamics system examples pneumatic hydraulic mechanical magnetic transmission systems driving rotary electrical generator linear electric generators provided
receptor associated protein eprap newly identified molecule regulates macrophage activation recently demonstrated presence eprap mice brain however little known function eprap tissue therefore investigated role eprap behavior emotion using behavioral analysis mice study subjected eprap deficient mice wild type cbl mice battery behavioral tests eprap mice tended shorter latencies fall wire hang test normal neuromuscular strength eprap mice exhibited elevated startle responses reduced pre pulse inhibition compared mice eprap mice increased depression like behavior forced swim test abnormal behaviors partially mimic symptoms depression attention deficit hyperactivity disorder adhd schizophrenia methylphenidate administration increased locomotor activity less eprap mice mice finally levels norepinephrine reduced eprap mouser brain behavioral abnormalities eprap mice may result dysfunction monoamines particular norepinephrine results suggest eprap participates pathogenesis various behavioral disorders elsevier inc rights reserved
background objective idiopathic pulmonary fibrosis ipf progressive disease poor prognosis variable clinical course although matrix metalloproteinase mmp emerging important ipf biomarker reproducibility across studies unclear aimed determine whether previously reported prognostic threshold mmp predictive mortality independent cohort ipf patients methods mmp concentrations obtained heparinized plasma samples determined elisa patients ipf healthy controls association previously published heparin plasma mmp threshold cause mortality transplant free survival tfs determined either independent biomarker part modified personal clinical molecular mortality index pcmi results mmp plasma concentrations significantly higher ipf patients compared healthy controls plasma mmp threshold significantly associated cause mortality tfs unadjusted cox proportional hazard ratio respectively mmp concentrations split significantly predictive mortality tfs adjusting age gender smoking baseline pulmonary function parameters multivariate cox proportional hazards model mmp concentrations negatively correlated diffusing lung capacity carbon monoxide dlco positively mortality risk scoring system gap combines age gender forced vital capacity fvc dlco conclusion study confirms mmp concentrations could used accurately predict outcomes across cohorts centres similar collection protocols applied
increasing modernization urbanization asia much future focus obesity epidemic asian region low testosterone levels frequently encountered obese men otherwise recognizable hypothalamic pituitary testicular hpt axis pathology moderate obesity predominantly decreases total testosterone due insulin resistance associated reductions sex hormone binding globulin severe obesity additionally associated reductions free testosterone levels due suppression hpt axis low testosterone leads increasing adiposity creating self perpetuating cycle metabolic complications obesity associated hypotestosteronemia functional non permanent state reversible requires substantial weight loss testosterone treatment lead moderate reductions fat mass obesity absence symptomatic androgen deficiency established indication testosterone therapy testosterone therapy may lead worsening untreated sleep apnea compromise fertility whether testosterone therapy augments diet exercise induced weight loss requires evaluation adequately designed randomized controlled clinical trials
survey conducted determine geometry operating parameters key features large circular octagonal culture tanks used produce atlantic salmon smolt post smolt six major norwegian atlantic salmon production companies total large tanks reported seven land based hatchery locations averaging range large tanks per land based site addition one floating fiberglass tank sea reported culture volume ranged land based tank tanks circular one site used octagonal tanks land based tank diameters ranged diameter whereas floating tank diameter maximum tank depths ranged mat land based facilities produced diameter average depth ratios floating tank much deeper diameter average depth ratio land based tanks floors sloping toward tank center various pipe configurations penetrated culture tank water volume tank center pipes sloping floors used reduce labor removing dead fish harvesting fish maximum flow ranged min per land based tank min floating tank tank flow adjustable facilities land based tanks flushed mean hydraulic retention time hrt min maximum feed load land based tank ranged day floating tank reached day almost half large tanks reported survey installed renovated since including three tank systems highest flow rate per tank greater min recent tanks operated rapid tank hrt min min hrt typical large tanks built addition flow per unit feed load land based tanks began operating lower flow feed tanks began operating later flow feed comparison floating tank operates maximum daily tank flow feed load flow feed least intensive tanks surveyed survey results suggest recently built tanks designed operate reduced metabolic loading per unit flow tendency would improve water quality throughout culture tank else equal trend possible due ever increasing application water recirculating systems authors published elsevier
rheumatoid arthritis chronic systemic autoimmune disease complex unclear etiology hypotonicity synovial fluid typical characteristic may play pivotal roles pathogenesis work studied responses synovial fibroblasts hypotonic stress vitro explored underlying mechanisms data showed hyposmotic solutions significantly triggered increases cytosolic calcium concentration synoviocytes subsequently caused rapid release atp well remarkable production intracellular reactive oxygen species ros meanwhile hypotonic stimulus promoted proliferation synovial fibroblasts effects almost abolished calcium free buffer significantly inhibited gadolinium iii chloride mechanosensitive channel blocker ruthenium red transient receptor potential vanilloid trpv blocker phorbol didecanoate specific agonist trpv also mimicked hypotonic shock induced responses shown contrast voltage gated channel inhibitors verapamil nifedipine little influences responses furthermore pcr western blotting evidently detected trpv expression mrna protein level isolated synoviocytes taken together results indicated hypotonic stimulus resulted atp release ros production cell proliferation depending entry activation trpv channel synoviocytes elsevier inc rights reserved
show thz absorptance metals significantly increased structuring surface metals array parallel grooves produced scanning femtosecond laser beam study enhance absorptance titanium wavelength thz even without optimization surface structure finding shows femtosecond laser surface structuring technology suitable creating highly absorptive metal materials variety terahertz submillimeter waves applications including terahertz spectroscopy thz sensing thz stealth technology space astronomy
current distributed routing control algorithms dynamic networks model networks using time evolution density network edges routing control algorithm ensures edge density converge wardrop equilibrium characterized equal traffic density used paths rearrange density model recast problem within framework mean field games illustrate extended state space solution approach study stochastic case density evolution driven brownian motion investigate case density evolution perturbed bounded adversarial disturbance stochastic worst case scenarios provide conditions density converge pre assigned set moreover analyze conditions two different perspectives repeated games vector payoffs inclusion theory
revocation key evolving paradigms central issues cryptography pki particular novel concern related areas raised recent work sahai seyalioglu waters crypto noticed revoking past keys times scenario cloud storage accompanied revocation past ciphertexts prevent unread ciphertexts read revoked users introduced revocable storage attribute based encryption abe good access control mechanism cloud storage abe protects revoked users future data supporting key revocation also past data supporting ciphertext update ciphertext time updated new ciphertext time using public key motivated pioneering work ask whether possible modular approach includes primitive time managed ciphertext update primitive call encryption supports primitive self updatable encryption sue suggest modular cryptosystems design methodology based three sub components primary encryption scheme key revocation mechanism time evolution mechanism controls ciphertext self updating via sue method coordinated revocation needed goal allow self updating ciphertext component take part design new improved cryptosystems protocols flexible fashion specifically achieve following results first introduce new cryptographic primitive called self updatable encryption sue realizing time evolution mechanism sue ciphertext private key associated time user decrypt ciphertext time earlier private key additionally anyone cloud server update ciphertext ciphertext newer time also construct sue scheme prove full security static assumptions following modular approach present new abe scheme shorter ciphertexts sahai prove security length efficiency mainly due sue scheme underlying modularity apply approach predicate encryption supporting attribute hiding property obtain revocable storage scheme selectively secure demonstrate sue independent interest showing used timed release encryption applications augmenting key insulated encryption forward secure storage elsevier rights reserved
background gravity omnipresent earth however humans space astronauts international space station experience microgravity long term exposure microgravity considered elicit physiological changes muscle atrophy human body addition certain types cancer cells demonstrate inhibited proliferation condition time averaged simulated microgravity tasmg however response human hodgkin lymphoma cancer cells reduced gravity associated physiological changes cells elucidated methods study proliferation human hodgkin lymphoma cancer cells hdlm tasmg condition defined studied using clinostat normal human dermal fibroblast hdf proliferated condition control group development clinostat two motors used actuate frames electrical wires power supply communication connected via slip ring symmetrical path gravitational vector optimal angular velocities motors found using simulation results condition tasmg implemented clinostat proliferation cells observed days results results indicated proliferation cancer cells significantly inhibited tasmg whereas proliferation normal hdf cells affected conclusions findings study could significantly valuable developing novel strategies selective killing cancer cells lymphoma
introduction omalizumab used treatment severe allergic asthma intended mechanism action based anti ige proprieties however recent studies highlighted mechanisms action state art omalizumab treatment associated decrease number dendritic cells lymphocytes eosinophils anti inflammatory activity characterized decrease levels several cytokines involved recruitment activation survival eosinophils mastocytes orientation immune response modulation bronchial remodeling omalizumab recently shown decrease production extracellular matrix components proliferation smooth muscle cells could involved modulation mechanisms action could explain part clinical efficiency omalizumab non allergic conditions non allergic asthma non allergic urticaria nasal polyposis conclusion precise knowledge mechanisms action omalizumab could allow identification biomarkers predictive efficacy treatment could useful tools phenotyping severe asthma splf published elsevier masson sas rights reserved
past ten years human identification received increased attention computer vision research community however part research papers divorced context algorithms would used real world system paper describes unique opportunity group academic researchers design deploy human identification system demanding real world environment busy airport system designed ground including robust modules realtime human detection tracking distributed low latency software architecture front end user interface designed specific scenario none issues typically addressed identification research papers critical effective system end users would actually willing adopt detail challenges real world airport environment computer vision algorithms underlying human detection identification algorithms robust software architecture ground truthing system required provide training validation data algorithms initial results show despite challenges constraints airport environment proposed system achieves good performance operating real time
objective provide evidence consensus based recommendations concerning assessment management sleep problems youths attention deficit hyperactivity disorder adhd method pubmed ovid embase web knowledge searched october evidence available consensus authors achieved evidence level recommendations management sleep disturbances based scottish intercollegiate guidelines network sign system results total original articles sleep childhood adhd retrieved including treatment sleep disturbances review focuses behaviorally based insomnia circadian rhythm disorder sleep disordered breathing restless legs syndrome periodic limb movement disorder sleep disturbances due comorbid psychiatric disorders adhd medications healthy sleep practices recommended foundation management strategies behavioral interventions considered first line treatment insomnia although evidence randomized controlled trials rcts needed prove efficacy adhd among pharmacological treatments rcts support use melatonin reduce sleep onset delay whereas limited evidence medications conclusion growing empirical evidence informing assessment management strategies sleep problems youths adhd however rcts warranted support current recommendations
pregnancy birth survey started fukushima medical university part fukushima health management survey order assess physical mental health mothers provide parenting support telephone counseling need present study reviewed major findings annual surveys conducted overall proportions preterm deliveries low birth weight infants congenital anomalies first year almost national surveillance data prevalence depressive symptoms among mothers held steady years regarding content parenting counseling proportion mothers voiced concerns radiation decreased year survey continued provide support mothers fukushima
various algorithms optimal control require explicit determination switching surfaces however switching strategies may complicated computation switching surfaces quite challenging general methods proposed compute switching surfaces systematically based algebraic computational tools triangular decomposition methods highly complex compared widely used numerical options made feasible real time applications moving computational burden line tutorial style presentation intended introduce potentially powerful symbolic computation methods system scientists particular illustrative example time optimal control given show effectiveness generality approach
biogas fired tri generation system cooling heating electricity generation bcchp supported photovoltaic system discussed analyzed energetic ecological effectiveness point view analyzed system based internal combustion engine adsorption machine evaluation primary energy savings bcchp aided system indicators total primary energy savings tpes relative primary energy savings apes defined also analysis carried reduction greenhouse gases emission ecological potential evaluation environmental impact indicator total greenhouse gasses reduction tghgr taken account presented detailed algorithm evaluation multigeneration system global balance boundary applied analysis energy effects consumption primary energy well ecological effect emission greenhouse gasses real data hour hour year operation taking account random availability renewable energy allows take account important factor characterized renewable energy systems res variability random availability case photovoltaic primary energy particularly presented work effects analysis application discusses algorithms demonstrated hour hour availability solar radiation daily changing availability chemical energy biogas additionally energy ecological evaluation algorithms integrated methods offered exergy analysis case cogeneration systems problem allocation fuel useful products heat electricity commonly applied methods energetic division take account different quality products generated cogeneration unit moreover methods require subjective assumptions lead cases non physical results fuel allocation commonly known exergy losses decide amount consumed energy driving production process considered process two products generated losses proportionally allocated products reason correct allocation also done application exergetic allocation proposed algorithm presented paper elsevier ltd rights reserved
paper study self taught learning hyperspectral image hsi classification supervised deep learning methods currently state art many machine learning problems methods require large quantities labeled data effective unfortunately existing labeled hsi benchmarks small directly train deep supervised network alternatively used self taught learning unsupervised method learn feature extracting frameworks unlabeled hyperspectral imagery models learn extract generalizable features training sufficiently large quantities unlabeled data distinct target data set trained models extract features smaller labeled target data sets studied two self taught learning frameworks hsi classification first shallow approach uses independent component analysis second three layer stacked convolutional autoencoder models applied indian pines salinas valley pavia university data sets captured two separate sensors different altitudes despite large variation scene type algorithms achieve state art results across three data sets
background date effects exclusive breastfeeding duration timing solid food introduction allergy prevention unclear aim study determine effect variable feeding practices intestinal inflammation infants using faecal eosinophil cationic protein surrogate marker assess whether faecal eosinophil cationic protein associated serum immunoglobulin methods subjects enrolled prediction allergies taiwanese children patch birth cohort study stool samples collected months determining eosinophil cationic protein blood collected determining total allergen specific immunoglobulin months compared biomarkers infants variable exclusive breastfeeding duration infants introduced solid foods various periods association faecal eosinophil cationic protein total serum immunoglobulin specific immunoglobulin also analysed results faecal eosinophil cationic protein significantly higher exclusively breastfed infants compared formula fed infants infants exclusively breastfed months age months reduce serum immunoglobulin rather increased intestinal inflammation faecal eosinophil cationic protein associated total serum immunoglobulin specific immunoglobulin might useful indictor immunoglobulin sensitization infancy
objective examined mediating roles coping depression anxiety encountering difficult sexual situations explaining association stigma men sex men msm hiv risk methods conducted path analyses using longitudinal data collected chinese msm beijing baseline months months results msm stigma specifically anticipations stigma marginally significant protective total effect unprotected anal intercourse months overall association however byproduct significant indirect associations risk enhancing protective routed coping anxiety difficult sexual situations note heavier use avoidant coping principally protective effect risk behavior decreasing difficult sexual situations conclusions interventions reduce avoidant coping would important tool improving emotional well chinese msm interventions however must paired biomedical behavioral hiv prevention strategies ensure benefit undermined unintended increased hiv transmission risk response reduced social isolation among msm
critical heterosexuality studies demonstrate role traditional white wedding reproduction heteronormativity gender contribute social order privileges white middle class heterosexual married couples relationships however social science research points ways sex weddings offer site resistance heteronormativity traditional gender roles analyze depth interviews women straight sex marriages find women straight marriages likely embrace traditional white wedding sex marriages women planning sex weddings think deeply wedding ceremonies relate heteronormativity participants reject traditional weddings excessively costly wasteful argue although weddings often sites celebration consumerism traditional gender heterosexuality also sites resistance challenge social norms
study carried determine predictors health promoting behaviors hpbs patients coronary artery diseases cad iranian population cross sectional descriptive study eligible patients ages years body mass index bmi cad admitted cardiac hospital urmia iran participated valid questionnaires used health promoting lifestyle profile hplp cardiac self efficacy cse general self efficacy gse scales assess hpbs cse gse respectively fifty five percent participants men mean age years hierarchical multiple regression analysis indicated cse gse education bmi best predictors hpbs respectively model predicted hpb change adjusted responsibility health spiritual growth motivates patients apply hpbs however physical activity stress management least applied
china rapid economic growth causes sharp increase demand electricity electricity price china generally controlled low level government leading substantial electricity subsidy electricity subsidy focus energy price reform also closely linked residential life sensitive issue residents paper adopts price gap approach estimate scale electricity subsidy finds residential electricity subsidy china amounted billion cny chinese yuan accounting gdp year subsequently paper estimates impacts residential electricity subsidy reform welfare residents using compensating variation measurement results show residential electricity price rises billion cny respectively residential electricity subsidy reform also moderating role rebound effect electricity consumption direct rebound effect china residential electricity consumption electricity subsidy reform raise terminal electricity price restrain residential electricity consumption therefore electricity subsidy reform effective measure mitigate rebound effect
paper presents validation airflow network afn computational fluid dynamics cfd simulations naturally ventilated office building using wind tunnel measurements reference external pressure coefficients effective airflow rate prediction cfd simulation model also used study effect partially open windows effective flow rate study also includes design exercise naturally ventilated office building analyses differences predicted average window open area typical weather year results obtained show simple isolated buildings cfd predict pressure coefficients less average error cases interfering surrounding buildings complex building geometries average error less average errors bulk flow rates lower typically less largest errors occur effective flow rate predictions cases openings exposed recirculations shear driven flows
background aimthe first evidence based clinical practice guidelines principles care people dementia australia released guidelines detail number important evidence based recommendations occupational therapists aim paper provide overview guideline development describe evidence supporting recommendation occupational therapy common characteristics effective occupational therapy programmes people dementia described methodsguideline development involved adaptation existing high quality guidelines developed overseas systematic reviews ensure recent high quality evidence included one systematic reviews involved examining evidence interventions promote independence people dementia specifically looked evidence occupational therapy effect activities daily living quality life carer impact resultsa total recommendations included guidelines occupational therapy found significantly increase independence activities daily living improve quality life effective occupational therapy programmes involve environmental assessment problem solving strategies carer education interactive carer skills training conclusionoccupational therapists working people dementia community settings ensure time spent aspects intervention shown effective
objectives association cardiovascular disease depression well established peripheral arterial disease arises atherosclerosis like cardiovascular disease unlike cardiovascular disease impairs ambulation lower extremity function given peripheral arterial disease unique characteristics underrepresentation mental health research aimed assess prevalence depression depressive symptoms among peripheral arterial disease patients compared coronary artery disease rates assess whether independent association peripheral arterial disease depression exists identify associated factors may targeted intervention design study based systematic review materials methods electronic databases searched identify studies examined peripheral arterial disease depression depressive symptoms methodological quality assessed using newcastle ottawa scale results identified studies prevalence depression depressive symptoms ranged cross sectional studies longitudinal studies comparable reported coronary artery disease rates depressed peripheral arterial disease patients likely female african american severe peripheral arterial disease symptoms compromised physical function compared non depressed patients evidence suggest depression exerts negative influence walking ability physical function independently peripheral arterial disease conclusions critical need address depression peripheral arterial disease patients particularly characteristics place increased risk vascular care providers appear primary contact assessing depressive symptoms identified integrated mental health providers may intervene prevent worsening depression peripheral arterial disease
paper first time report nonmonotonic dependence snapback voltage buried oxide thickness box silicon insulator laterally double diffused mos soi ldmos transistors step step analysis effect carried decoupling self heating impact ionization effects cause turning parasitic bipolar junction transistor bjt subsequently snapback effect observed ldmos transistors low box increases increase box due reduction drain current density well reduced impact ionization higher lattice temperature hand high box reduces increase box due early switching parasitic bjt higher temperature therefore possible find optimum value box obtain highest soi ldmos transistor interesting observation proper choice box safe operating area soi ldmos corresponding bulk ldmos physics based compact model developed implemented verilog compared technology computer aided design simulated results model exhibits high level accuracy
purpose atopic dermatitis chronic eczematous dermatitis high prevalence diverse clinical features although several hypotheses multifactorial pathogenesis suggested cause yet fully understood better understanding clinical features may helpful inelucidating pathogenesis methods retrospective study analyzed questionnaires medical charts laboratory examination results patients diagnosed single tertiary hospital korea results demographics allergic comorbidities family history severity treatment experiences patients analyzed patients adults classified havingan extrinsic type mean eczema area severity index easi score found adult patients found higher severity age groups anatomical involvements different among age groups involvements head neck adults patients reported seasonal changes stress factors aggravated symptoms topical steroids oral cyclosporine used medications clinic whereas patients underwent allergen specific immunotherapy conclusions analysis patients would lead better understanding various subtypes diverse clinical features koreans distinct characteristics observed among different age groups thus treatment strategies may need differentiated accordingly
background supervised injection facilities sifs legally sanctioned environments people inject drugs medical supervision sifs currently operate ten countries date sif opened usa light increasing overdose mortality usa study evaluated willingness use sif among youth report non medical prescription opioid nmpo use methods january february youth recent nmpo use recruited participate rhode island young adult prescription drug study rapids explored factors associated willingness use sif among participants injected drugs risk initiating injection drug use defined sex partner injects drugs close friend injects results among eligible participants median age iqr male white among participants asked would use sif answered yes answered unsure among participants reporting injection drug use last six months reported willingness use sif injected less daily reported willingness participants injected daily reported willingness compared participants unwilling unsure participants willing use sif also likely homeless last six months accidentally overdosed used heroin used fentanyl non medically typically use prescription opioids alone conclusions among young adults use prescription opioids non medically inject drugs risk initiating injection drug use six ten reported willingness use sif established risk factors overdose including homelessness history overdose daily injection drug use heroin use fentanyl misuse associated higher sif acceptability indicating young people highest risk overdose might ultimately individuals use facility supervised injection facilities merit consideration reduce overdose mortality usa
background extremely high percentage children worldwide exposed stress first months life aim review bring together experimental results related chronic early life stress human experimental models methods aimed achieve objective via thorough review literature results early life stress challenge developing organism leads negative effects medium long term emotional cognitive behavioral domains compromised due alterations produced nervous system important related main neurotransmission systems conclusions using experimental models possible address study structural functional changes resulting early life stress thus plan intervention prevention alternatives
eating disorders hold unique place among mental health disorders salient symptoms objectively observed measured rather determined patient interviews subjective evaluations measurement advantage alone evidence based medicine would expected make rapid strides however conclusions eating disorders research medical research literature often continue misleading ambiguous one major long known source problems misuse misinterpretation statistical significance values strewn throughout research papers like much confetti problem become systemic enforced rather corrected peer review system discussion attempts clarify issues suggest readers might deal issue processing research literature
existing analytical solutions steady state temperature field straight row piped freezing artificial ground freezing cover single piped multi piped single row piped double row piped freezing yet sufficient meet needs construction projects triple row piped even multi row piped freezing increasingly adopted paper original engineering problems temperature field single piped row piped freezing firstly converted solving plain laplace equation specified boundary conditions based superposition thermal potential analytical solutions steady state temperature field single piped single row piped double row piped freezing deduced succession solution triple row piped freezing obtained validated comparison thermal numerical analysis furthermore formula calculating thickness triple row piped frozen soil wall proposed important construction management artificial ground freezing elsevier ltd rights reserved
despite value emergency contraception reducing unintended pregnancy use college women widely studied exploratory descriptive study using web based survey described knowledge use college women identified associations selected personal characteristics use women knew could obtained counter effective within intercourse women inaccurately thought effective first trimester pregnancy could cause birth defects among sexually active women reported use experiencing false alarm pregnancy knowing available counter asian pacific islander positively associated use additional studies explore utility populations efforts stepped provide accurate information access mechanism use
contextual based image classification attempts considering spatial temporal information learning process order make classification process smarter sequential learning techniques one used ones perform contextual classification based two step classification process traditional noncontextual learning process followed one step classification based extended feature vector paper propose two ensemble based approaches make sequential learning techniques less prone errors since effectiveness strongly dependent feature extension process ends adding wrong predicted label neighborhood samples new features proposed approaches validated context land cover classification results considerably better state art techniques literature
background adults high blood pressure adverse serum lipids smoking associate cognitive deficits effects risk factors childhood midlife cognitive performance unknown objectives study sought investigate associations childhood adolescence cardiovascular risk factors midlife cognitive performance methods population based cohort children baseline age years followed years year intervals serum lipids body mass index smoking assessed follow ups cumulative exposure area curve risk factor determined childhood years adolescence years young adulthood years cognitive testing performed participants aged years results high systolic elevated serum total cholesterol smoking childhood independently associated worse midlife cognitive performance especially memory learning number early life risk factors including high levels extreme percentile cumulative risk exposure ages years systolic total cholesterol smoking associated inversely midlife visual episodic memory visuospatial associative learning standard deviations per risk factor remained significant adjustment contemporaneous risk factors individuals risk factors within recommended levels ages years performed standard deviations better cognitive domain exceeding risk factor guidelines least twice difference corresponds effect years aging cognitive domain conclusions cumulative burden cardiovascular risk factors childhood adolescence associate worse midlife cognitive performance independent adulthood exposure american college cardiology foundation
background treatment neuropsychiatric symptoms nps dementia insufficient antipsychotics acetylcholinesterase inhibitors used generating symptomatic improvements behavior cognition studies investigated effect alzheimer disease biomarkers cerebrospinal fluid csf objective secondary analysis based earlier clinical trial comparing treatment effects nps aim study examine whether treatment risperidone galantamine affect levels biomarkers tau tau beta beta ratio csf secondary aim test baseline levels biomarkers associated clinical course nps methods patients mean years dementia nps randomized galantamine risperidone treatment csf samples collected baseline weeks results changes levels biomarkers two treatment groups differ significantly low baseline levels beta significantly associated reduction irritability follow low baseline levels beta beta tau significant correlates reduction appetite eating disorders csf beta levels patients treated risperidone significantly decreased follow showing reduction compared baseline conclusions results suggest risperidone may affect csf profile biomarkers indicating amyloid pathology treatment galantamine affect csf biomarkers direction adcsf biomarkers displayed correlations specific nps suggesting potential research questions pursued
backgroundskin protective barrier exogenous substances modulated various internal external factors affect functional state order prevent early symptoms signs diseases skin frequent skin health assessment performed aims study evaluate four skin properties transepidermal water loss tewl hydration elasticity pigmentation using non invasive skin assessment tool dermalab combo also determine possible factors may influence skin condition methodsdermalab combo used measure tewl hydration pigmentation elasticity forearm volunteers using different probes study four parameters observed reflect health skin volunteers resultsthere significant differences tewl hydration pigmentation elasticity different genders anatomical site forearm female subjects higher average value tewl hydration elasticity compared male subjects differences may due individual daily activity use skin care products well environmental factors use moisturiser drinking lots water may keep skin hydrated delay process skin ageing shown better hydration elasticity observed conclusionin study concluded dermalab combo reliable skin analysis instrument offers high precision accuracy reproducibility measuring parameters also found daily activities habits influence skin condition reflected measurement biophysical skin parameters
log messages generated debug statements developers insert code runtime contain rich information runtime behavior software systems log messages used widely system monitoring problem diagnoses legal compliances yuan performed first empirical study logging practices open source software systems studied development history four server side projects derived ten interesting findings paper performed replication study order assess whether findings would applicable java projects apache software foundations examined different java based open source projects three different categories server side client side supporting component similar original study results show projects contain logging code actively maintained however contrary original study bug reports containing log messages take longer time resolve bug reports without log messages significantly higher portion log updates enhancing quality logs formatting style changes spelling grammar fixes rather changes feature implementations updating variable names
study thermal performance tamar suspension bridge deck plymouth presented paper ambient air suspension cable deck truss temperatures acquired using wired sensor system deck extension data acquired using two hop wireless sensor network empirical models relating deck extension various combinations temperatures derived compared accurate model used four temperature variables predicted deck extension accuracy time delays ranging min identified daily cycles air temperature structural temperatures deck extension however accounting delays temperature extension models improve models prediction accuracy results study suggest bridge design recommendations based overly simplistic assumptions could result significant errors estimated deck movement especially temperature extremes findings aim help engineers better understand important aspect thermal performance steel bridges paper also presents concise study effective use shelf wireless technology support structural health monitoring bridges
epidemiological studies show maternal immune activation mia pregnancy risk factor autism however mechanisms mia affects brain development behaviors offspring remain poorly described determine whether placental interleukin signaling required mediating mia offspring generated mice restricted deletion receptor rot placental trophoblasts cyp cre llra tested offspring cyp cre llra mothers immunological pathological behavioral abnormalities following induction mia reveal mia results acute inflammatory responses fetal brain lack signaling trophoblasts effectively blocks mia induced inflammatory responses placenta fetal brain furthermore behavioral abnormalities cerebellar neuropathologies observed mia control offspring prevented cyp cre llra offspring results demonstrate activation placenta required relaying inflammatory signals fetal brain impacting behaviors neuropathologies relevant neurodevelopmental disease elsevier inc rights reserved
borderline personality disorder bpd diagnosis defined impairments several dynamic processes interpersonal relating affect regulation behavioral control theories bpd emphasize impairments appear specific contexts emerging results confirm view time bpd complex construct encompasses individuals heterogeneous pathology featuresdynamic processes situational specificity individual heterogeneitypose significant assessment challenges current study demonstrate assessment analytic methods capture person differences within person changes time twenty five participants diagnosed bpd completed event contingent ambulatory assessment protocols days used technique factor analyses identify person specific psychological structures consistent clinical theories personality five exemplar cases selected presented detail showcase potential utility methods presented cases factor structures reflect heterogeneity also suggest points convergence factors also demonstrated significant associations important clinical targets self harm interpersonal violence
quick development innovation moves plan best choice accurate mission numerous independent automated innovations intimated lives individuals making work much easier seen automated vehicles presented far shrewd abilities enormous measures cash spent yearly examination paper autonomous maze solving robot developed independent mapping localization skill firstly maze solving vehicle designed three infrared sensors two used wall detection avoid collision third obstacle detection picking placing objects clear pathway help robotic arm also desires use robot environment unreachable human addition also places use robots way achieve goal appropriate placement sensory devices critical successfully implemented maze solving ability onto robot called mazebot tested robot solve maze successfully without interruption walls objects design accuracy measurements real time processing allied minimum processing power key components overall embedded design authors published elsevier
shift towards electrical aircraft bringing many new technologies redesign existing aircraft electrical network require thorough testing implementation led creation copper bird test bench recreates aircraft electrical system used equipment evaluation validation paper details development accompanying virtual electrical test bench modelling real time simulation operation aircraft electrical system conducting verification activities different aircraft electrical architectures developing energy management strategies paper particular attention given pem fuel cell model characterized validated using scaled version electrical test bench model shows good accuracy giving average error less max error fuzzy logic based energy management developed fuel cell battery based auxiliary power unit fuel cell supplying average load power whilst acting current source battery handling load transients overload situations energy management attains goals operating fuel cell average power order extend lifetime whilst maintaining battery state charge also order extend lifetime well maintaining ability absorb excess generated power
diagnostic criteria eating disorders remain largely based clinical presentations capture full range behaviours population aimed derive empirically based behaviour classification using behavioural body mass index bmi indicators three time points adolescence validate classes investigating prospective associations adverse outcomes adolescents avon longitudinal study parents children alspac provided data age years weight height measured psychological behavioural outcomes assessed years fit gender age stratified latent class models employed logistic regression investigate associations classes later outcomes one asymptomatic two symptomatic largely representing higher lower frequency behaviours classes observed time point although relative prevalence varied age gender majority girls symptomatic classes remained symptomatic subsequent assessments girls symptomatic classes higher odds subsequent anxiety depressive disorders binge drinking drug use deliberate self harm data analyses underpowered amongst boys presence two symptomatic classes characterised different behaviour frequency prospective association adverse outcomes suggest need refine diagnostic thresholds based empirical data despite instability classes particularly mid adolescence evidence half girls symptomatic classes remained symptomatic suggests persistence behaviours adolescence highlights need early identification reduce chronicity
study examines factorial invariance scale beliefs children adjustment sex families sbcassf across countries three samples chilean spanish hispanic university students scale analyzes attitudes toward consequences rearing education children parents homosexual sexual orientation instrument consists two subscales individual opposition normative opposition spanish sample composed university students chilean sample made students hispanic sample consists students results provide empirical evidence reliability sbcassf samples countries factorial invariance strict invariance results also provided differences countries sex sbcassf could potentially useful measure educators psychologists mental health professionals wish study beliefs child rearing practices sex parents
industry sector accounts third global final energy consumption nearly share global energy related emissions compared sectors however industrial energy modelling received less attention due variety sub sectors impact energy saving measures product qualities statistical problems paper explains industry sector modelled world energy outlook presents energy saving opportunities energy efficiency sector using world energy model partial equilibrium model found exploiting economic potential energy efficiency reduce energy demand growth industry per year average period savings arise faster adoption efficient technologies phasing older facilities process change system optimisation including electric motor driven systems significant barriers implementation energy efficiency requirement short payback periods concerns change could interrupt production affect reliability order realise potential energy savings policy makers need address issues improving mechanisms capacity building energy management financing
endeavor paper study potential offered expenditure innovative solar combisystem scs used space heating load domestic hot water supply electric energy production investigation achieved work based experimental simulation studies trnsys simulation program achieved order evaluate scs monthly annual thermal electric performances found proposed scs covered energy needs considering solar energy result shows also scs provided total dhw needs also found scs electric production ranged gain factor varying economic appraisal also achieved appraise scs feasibility results economic analysis show annual energy saved payback period based electric water heater respectively equal year years found based gas gas town years respectively results economic analysis shows adoption scs saves electric energy gas gas town kept back conventional system elsevier ltd rights reserved
volunteerism community involvement demonstrated offer benefits communities volunteers however every method encourage behaviors equally effective producing committed volunteers drawing relevant theoretical empirical literatures identify features efforts likely produce intrinsically motivated oriented volunteers may produce extrinsically motivated self oriented volunteers particular explore ways socialize young people help ways build sense community focused particular issues also examine requirements community service approaches highlight self oriented benefits volunteers may obtain finally return focus importance intrinsic motivation promoting sustained involvement volunteers even acknowledge volunteers come extrinsic self oriented reasons still offer much communities satisfied activities match motivations
attempt tackle shortcomings current approaches collaborating development structured data sets present prototype platform allows users share collaborate development data structures via web application using language bindings api using techniques theory persistent linked data structures resulting platform delivers automatically version controlled map graph abstract data types web service core system provided hash array mapped trie hamt made confluently persistent path copying system aims make efficient use storage consistent access update times regardless version accessed modified
data processing complexity partitionability locality provenance play crucial role effectiveness distributed data processing dynamics data processing necessitates effective modeling allows understanding reasoning fluidity data processing virtualization resources become scattered heterogeneous dynamic performance networking paper propose new distributed data processing model based automata data processing modeled state transformations approach falls within category declarative concurrent paradigms fundamentally different imperative approaches communication function order explicitly modeled allows abstraction concurrency thus suited distributed systems automata give way formally describe data processing independent underlying processes also providing routing information route data based current state fashion around networks distributed processing nodes implementation named pumpkin model capture automata schema routing table data processing protocol show globally distributed resources brought together collaborative way form processing plane data objects self routable plane elsevier rights reserved
bioretention cells brcs increasingly popular stormwater control measure used mitigate hydrologic water quality impacts urbanization previous brc research demonstrated strong capacity pollutant removal however long term sequestration pollutants within soil media elevate concentrations levels fostering environmental human health risks soil media samples collected year old brc charlotte analyzed accumulation spatial distribution zinc copper phosphorus pollutant distribution varied significantly respect depth ordinate distance brc inlet zinc concentrations soil exceeded environmental thresholds phosphorus concentrations soil increased initial levels factor seven however notable accumulation restricted brc forebay maximum zinc copper concentrations soil media exceed mandatory cleanup levels regular maintenance forebay effective life brc media exceed life developments treat elsevier ltd rights reserved
paper presents size effect fracture toughness polyurethane foams pur nominal density closed cell rigid foams widely used sandwich cores determination fracture toughness carried three point bending tests tpb notched specimens room temperature degrees determine size effect mode fracture toughness specimens geometrically similar two dimensions length width ratio selected specimens subjected quasi static loading speed min applied exactly notch direction strong size effect closed cell pur foam experimentally demonstrated considering smooth transition strength materials approach size effect asymptotic case linear elastic fracture mechanics
despite widely accepted concept probiotics confer miscellaneous benefits hosts controversies surrounding health promoting claims ignored controversies hinder development innovation field clarify effects age gender probiotic induced immune responses recruited taiwanese individuals calculated ratio ifn gamma production individual pbmcs stimulated six probiotic strains paracasei brap acidophilus longum faecium rhamnosus reuteri results indicated gender age minor effects immune modulation probiotics additionally showed paracasei brap acidophilus two dominant strains inducing ifn gamma production taiwanese individuals reuteri effective stimulator ifn gamma additionally significant inverse relationship ability paracasei brap rhamnosus stimulate ifn gamma ifn gamma production also observed results indicated age gender minor effects immune modulation abilities probiotics
paper focuses learning post processing composite materials current context manufacturing engineering education spain use composites significantly increased different sectors industry last decades students taking manufacturing courses engineering study plans need basic formation concerning post processing composites due complexity process powerful numerical tools needed develop practical models focused damage prediction learning skills include modeling anisotropic materials specific concepts composite machining induced damage
emotion reactivity emotion regulation salient constructs theories emotion emotion disorders however little known convergent discriminant validity instruments used measure current paper examines validity four emotion regulation three emotion reactivity instruments total subscales across three independent samples university students total eight subscales coping instrument also examined confirmatory factor analysis failed show expected patterns convergent discriminant validity however exploratory factor analysis revealed three different factors reflecting control negative emotion emotion awareness expression cognitive strategies emotion regulation results implications basic emotions research clinical science elsevier ltd rights reserved
paper describes high temperature voltage comparator operational amplifier amp silicon carbide sic cmos process circuits used building blocks designing high temperature sic low side current protection circuit current protection circuit used protection circuitry sic fet gate driver power converter applications amp comparator tested degrees degrees temperature respectively amp input common mode range gain unity gain bandwidth mhz phase margin degrees degrees comparator rise time fall time respectively degrees current protection circuit implemented analog building blocks designed sense voltage across sense resistor
paper deals issue field proxernics refers perception usage space way transmitting messages attitudes behaviors military certain situations defining concepts proxemics establishing four types distances humans intimate personal social public aim identify elements area characteristic drill romanian armed forces consequently work proposes particularly army reveal significations norms established military general regulations impact military personnel aim answer following research question romanian armed forces drill regulations take account aspects human topology role personal distances everyday transactions addition intend analyze comparative manner romanian foreign american european military drill regulations identify certain specific elements proxernics possess cultural connotations research methodology based mixed method consisting document study study distances military drill regulations
multi fractured horizontal wells mfhws effective technique developing shale gas reservoirs fracturing stimulated reservoir volumes srvs invariably exist around wellbore paper composite elliptical srv model hydraulic fracturing stage established based micro seismic events srv outer regions assumed single porosity media different formation physical parameters based unstructured perpendicular bisection pebi grids mathematical model considering darcy flow diffusion adsorption desorption shale gas reservoirs presented numerical solution obtained combining control volume finite element method fully implicit method model verified simplified model solution mfhw blasingame production decline curves consider elliptical srvs shale gas reservoirs plotted computer programming flow regions divided five flow regimes early formation linear flow radial flow srv region transient flow pseudo radial flow boundary dominated flow finally effect six related parameters including srv area size outer region permeability srv region permeability langmuir pressure langmuir volume diffusion coefficient analyzed type curves model presented paper expand understanding mfhw production decline behaviors shale gas reservoirs applied estimate reservoir properties srv area reserves types reservoirs type curve matching
four studies tested support idea implicit theories fixedness versus malleability gender roles entity incremental theories predict differences degree gender system justification support status quo relations women men society relative incremental theory holding entity theory correlated system justifying attitudes self perceptions study men women alike also found strength identification one gender group stronger predictor system justification men women suggesting men defense status quo may motivated membership high status group social hierarchy experiments tested whether exposure fixed gender role theory would lead men identify masculine characteristics male gender group thus increasing defense gender system fair expect fixed gender role theory trigger identity motivated responses women overall found increasing degree psychological investment masculine identity adopting fixed gender role theory increased men rationalization gender status quo compared gender roles perceived changeable suggests men motivated align masculine identity likely endorse persistence gender inequality way affirming status real men
small rnas class short non coding endogenous rnas play essential roles many biological processes recent studies reported micrornas mirnas also involved ethylene signaling plants leerf one ethylene response factors erfs tomato locates downstream ethylene signal transduction pathway elucidate intricate regulatory roles small rnas ethylene signaling pathway tomato deep sequencing bioinformatics methods combined decipher small rnas landscape wild sense antisense leerf transgenic tomato fruits except known mirnas putative novel mirnas trans acting short interfering rnas sirnas natural antisense small interfering rnas nat sirnas also found results enriched tomato small rnas repository among small rnas mirnas nat sirnas differentially expressed wild transgenic tomato fruits significantly large amount target genes small rnas identified involved ethylene pathway including tfs auxin response factors box proteins erf tfs apetala like protein mads box tfs degradome sequencing confirmed targets mirnas six novel targets also discovered furthermore regulatory model reveals regulation relationships small rnas targets involved ethylene signaling set work provides basic information investigation function small rnas ethylene pathway fruit ripening
despite much attention including national initiatives concerns remain approaches managing behavior symptoms psychiatric conditions across settings including long term care settings nursing homes assisted living facilities one key reason problems persist efforts reform correct situation failed explore address root causes instead promoted inadequate piecemeal solutions improvement requires jumping bandwagon rethinking entire issue including recognizing applying key concepts clinical reasoning care delivery process every situation huge negative impact cognitive biases rote approaches related clinical problem solving decision making patient outcomes also must addressed amda society post acute long term care medicine
high telomerase expression hallmark types cancer therefore strategies inhibit telomerase anticancer treatment pursuit many years contrast cancer short telomeres lack telomerase associated aging age related disease including heart disease consequently pharmacological telomerase activation delay aging also provides cardioprotection viewpoint briefly summarized faces telomerase cancer aging discuss see therapeutic future telomerase activation rather inhibition treatment cardiac disease possibly even context cancer
application basal reinforced piled embankments earth structures approved method particularly traffic route engineering technique transferring static variable loads soil layers low bearing capacity soft clay deeper stiffer soil layers amongst others like cur ebgeo recommendations design analysis earth structures using geosynthetics reinforcements german society geotechnics dggt provides recommendations calculation design execution reinforced piled earth structures recommendations based specific geometrical mechanical load related boundary conditions fully transferable geotechnical applications traffic route engineering objective often minimize height bearing layer reinforced earth structure technical optimum reinforced base layer becomes essential predict stability arch also due cyclic loading well effects surface deformation bearing layer reliable way paper presents results three dimensional numerical simulation single layered reinforced piled embankment quasi static cyclic loading compares stress distribution geogrid current analytical methods
wound burn guidelines committee consists members commissioned board directors japanese dermatological association jda held several meetings evaluations writing since october drafted five guidelines diagnosis treatment including commentaries wounds general guidelines diagnosis treatment pressure ulcers taking opinions scientific committee board directors jda consideration
incidence breast cancer rise sub saharan africa ssa efforts early diagnosis successful public scant knowledge disease large percentage breast cancer cases diagnosed late mainly rural ssa women practice breast self examination poor paper argue examination social cultural contexts ssa influence breast cancer diagnosis management region needed discuss implications sociocultural factors gender roles spirituality breast cancer diagnosis management ssa
paper presents new topology emulating floating lossless negative inductance positive frequency dependent resistance resistance controlled resistance capacitance multipliers circuit uses three current feedback operational amplifiers cfoas three passive elements functionality proposed circuit verified using advanced design system ads software cfoa simulation results excellent agreement theoretical calculations
fast fourier transform algorithms large data sets achieve poor performance various platforms inefficient strided memory access patterns inefficient access patterns need reshaped achieve high performance implementations paper formally restructure ffts targeting generic machine model two level memory hierarchy requiring block data transfers derive memory access pattern efficient algorithms using custom block data layouts algorithms need carefully mapped targeted platform architecture particularly memory subsystem fully utilize performance energy efficiency potentials using kronecker product formalism integrate optimizations spiral framework evaluate family dram optimized fft algorithms hardware implementation design space via automated techniques evaluations demonstrate dram optimized accelerator designs large tradeoff space given various problem single double precision ffts hardware platform chip dram stacked dram asic fpga etc parameters show spiral generated pareto optimal designs achieve close theoretical peak performance targeted platform offering system performance power efficiency improvements respectively conventional row column fft algorithms
simulation applied tool learning training sports psychology medicine time current use potential training musicians less well understood aim study explore musicians perceptions experiences using simulated performance environments nine conservatory students performed two simulations interactive virtual elements vivid environmental cues recital virtual audience audition virtual judges qualitative data collected focus group interview written reflective commentaries thematic analysis highlighted musicians experiences terms anticipation using simulations process performing simulations usefulness simulation tool developing performance skills ways improving simulation training results show simulation new musicians individual levels immersion differed musicians saw benefits approach developing experimenting enhancing performance skills specifically musicians emphasised importance framing simulation experience plausible procedures leading following performance recognised potential combining simulation complementary training techniques
high growing supply database service solutions cloud platform vendors many enterprises still show moderate low demand even though migration daas solution might result significantly reduced bill maintenance data security privacy issues among reasons low popularity services migration also often justified could done seamlessly changes system possible transparent data encryption could help solutions tde shipped major database systems limited securing data rest appear useless machine could physically accessed adversary probable risk hosting cloud paper proposes different approach tde takes account cloud specific risks extends encryption cover data use partly data motion capable executing large subsets sql including heavy relational operations complex operations attributes transactions
pid control schemes widely used industrial control systems however difficult determine suitable set pid parameters industrial systems nonlinearity order overcome problem data driven pid pid control scheme based utilizing database proposed effectiveness investigated however pid controller two problems one training database line manner takes long time database requires large amount memory high computational cost micro controllers order train database line manner frit scheme combination database fictitious reference iterative tuning frit scheme proposed previous research according frit scheme pid controller trained line manner using set operating data paper address problem required memory computational cost method expresses pid controller simple nonlinear function using group method data handling gmdh proposed according proposed method pid controller trained advance using set operating data replaced network constructed adalines units expressed simple nonlinear function proposed method first explained effectiveness proposed method numerically evaluated simulation example
impedance spectroscopy powerful tool study frequency behavior supercapacitors comes pricy hardware postprocessing routines present non impedance method extract fractional order model parameters alpha alpha supercapacitor assumed equivalent series association resistance constant phase element using magnitude response measurement circuit consisting large bandwidth operational amplifier negative feedback theory behind measurement circuit along extraction method model parameters validation within error using simulated experimental results commercial supercapacitor presented discussed
present work reports synthesis novel oxo tetrahydroquinoline dioxo tetrahydroquinoline derivatives containing enaminone system bearing sulfonamide moiety newly synthesized compounds designed compliance general pharmacophoric requirements carbonic anhydrase inhibiting anticancer drugs may play role anticancer activity twelve newly synthesized compounds evaluated vitro anticancer activity human breast cancer cell line mcf compounds showed values respectively comparable reference drug doxorubicin hand compounds exhibited better activity doxorubicin values respectively
polycyclic aromatic hydrocarbons pahs products incomplete combustion organic materials commonly found particulate matter associated development asthma asthma exacerbation urban populations examined time spent home outdoors predictors exposures airborne pahs measured urinary hydroxypyrene glucuronide ohpg internal dose pahs children aged years baltimore weeklong periods saturday saturday four seasons daily activities assessed using questionnaires indoor air nicotine concentrations monitored urine specimens collected tuesday day saturday day measurement ohpg time spent non smoking homes associated significantly decreased ohpg concentration urine beta secondhand smoke shs exposures modified associations higher urinary ohpg concentrations children spending time smoking homes non smoking homes value interaction time spent outdoors associated increased urinary ohpg concentrations beta boys results suggest shs ambient outdoor air pollution contribute internal dose pahs inner city children
objective study examine association parenting stress functional impairment among children neurodevelopmental disorder ndd sample parents children diagnosed ndd recruited schools offer special education services parents completed self administered survey containing parenting stress index short form psi scale columbia impairment scale multiple logistic regression conducted compare clinically significant psi scores indicated risk parents clinically significant scores parenting stress increased times functionally impaired children ndd risk stress increased times parents reported disorder disease risk stress reduced higher college level education compared college level education findings might help health care providers initiate early intervention strategies peer support education prevent parenting stress reduce risk potential incidence depression
objective aim study assess whether time menstrual day embryo transfer expected menstrual cycle tetemc associated implantation women regular cycles materials methods forty women successful implantation forty women without implantation regular cycles randomly selected prospectively collected database assisted reproductive technology clinic zeynep kamil women children health training research hospital tetemc calculated case assess relationship successful implantation results comparison groups revealed significant differences regard tetemc menstrual period roc analyses tetemc auc menstrual period auc significant predictors clinical pregnancy cut value menstrual period found days sensitivity specificity cut value tetemc days sensitivity specificity conclusion longer menstrual cycle tetemc seem associated implantation failure
euclidean plane geometry evolute spline nurbs curves nurbs curves moreover evolute computed symbolically article extends results equiaffine plane geometry analogously euclidean geometry equi affine evolute spline nurbs curves nurbs curves algorithm symbolic computation given spline curves results new method analyze global affine differential properties spline curves assess spline curve quality affine invariant context
study examined attitudes police officers judiciary members toward wife abuse turkey relation attitudes profession ambivalent sexism hostile benevolent sexism gender gender roles following instruments used analyses attitudes toward wife abuse scale awas ambivalent sexism inventory asi bem sex role inventory participants police officers judiciary members selected different regions turkey results showed compared judiciary members police officers tolerant physical verbal abuse women marriage less tolerant idea victim leaving abusive marriage partner similarly men tolerant women husbands physically verbally abuse wives less supportive wife leaving abusive partner profession ambivalent sexism hostile benevolent sexism found strongest predictors attitudes toward wife abuse
basic part mechanical transmission gears high transmission accuracy gear precision measurement key technology based existing research computer vision technology introduced gear test according definitions technical indexes pitch deviation tooth thickness deviation etc analysis research new measurement method proposed complete determination modulus tooth number total accumulated pitch deviation gear proposed methods indexes pitch tooth thickness measured arc length rather chordal length consistent definitions measured points positioned reference circle gear pitch total accumulative pitch deviations examined finally gear measured proposed method main test obtained follows single pitch deviation total cumulative pitch deviation tooth thick deviation experiment demonstrates proposed method feasible effective meet precision need engineering practice study provides new solution method gear line measurement
background diabetes mellitus disease considered metabolic syndrome sugar metabolism impaired also said profound effects influence metabolic disorders almost metabolic pathways affected dreadful disease slow poison starts showing effects time progresses one commonest complaint seen diabetes patients loss libido derangement sexual physiology common complaints include erectile dysfunction mood elevations patients also complain stressfulness symptoms point towards common source decrease testosterone levels sincere effort put study understand relations total serum testosterone seen diabetes mellitus patients may help physicians operating surgeons also anaesthetists understand plethora metabolic disturbances seen diabetes mellitus take necessary steps correct conditions also take necessary preventive members may result catastrophe methods study cross sectional study done government medical college nizamabad one hundred known diabetic patients attended department surgery government medical college nizamabad identified fasting levels postprandial level hbac detected total testosterone level identified incidence low testosterone checked different levels glucose fasting postprandial hbac compared amount serum total testosterone finally time since diabetes known patients correlated levels testosterone result present study incidence low total testosterone found percent diabetics present study positive correlation total testosterone levels number years passed since patient known diabetic present study positive correlation found serum total testosterone levels mean fasting glucose levels mean postprandial mean hbac levels conclusion study intended help surgeons physicians anaesthetists managing patients diabetes mellitus better way especially pre postsurgical patients stress levels enormous testosterone also plays role controlling stress testosterone supplementation therapy considered patients study lot scope future gene identified cause obesity diabetes also lower serum testosterone present study forms base studies molecular level understanding disease better also managing patients better
objective investigate quality life qol psychosocial well youth neuromuscular disorders nmds wheelchair users data sources medline embase cinahl psycinfo january april reference lists retrieved full text articles study selection peer reviewed studies included data describing self reported qol psychosocial well could separately understood using wheelchairs years age records independently screened potentially eligible articles obtained examined reviewers twelve observational qualitative studies met inclusion criteria data extraction population representativeness measurement tools outcomes possible comparison groups two reviewers independently appraised studies risk bias internal validity generalizability data synthesis heterogeneity measurement reporting precluded meta analysis data cross sectional compared age typically developing peers physical qol scored consistently significantly lower youth nmds whereas psychosocial qol psychosocial qol highest youth nonambulant since early childhood recruited via single tertiary specialist clinics mental health social participation could compared age populations conclusions despite low physical qol psychosocial qol youth nmds appeared comparable age peers psychosocial well younger adolescents degenerative disease trajectories appeared compromised however longitudinal effects growing nmd mental health social participation unknown interpretation hampered poor description participant age sex physical ability lack population based recruitment strategies inconsistent use age appropriate measures understanding self reported qol psychosocial well youth nmds transitioning adulthood limited
patients spinal muscular atrophy sma risk poor bone health prevalence fractures low areal bone mineral density abmd score lateral distal femur osteoporosis sma subtype known aimed describe natural history bone health patients sma prior bisphosphonate treatment reviewed data eligible patients sma ages months years seen single institution january july fracture history reported annual clinic visits abmd obtained dual energy ray absorptiometry scans lumbar spine total body lateral distal femur patients abmd scores progressively lower worsening sma severity longitudinal abmd scores lateral distal femur decreased age fractures occurred patients femur common location fractures thirteen percent patients fulfilled criteria osteoporosis low abmd femur fractures highly prevalent sma subtypes young age however patients met criteria osteoporosis poor bone health may recognized comorbidity sma published elsevier
background ecological momentary assessments ema data collection approaches characterize behaviors real time however ema underutilized alcohol substance use research among men sex men msm aim analysis explore correlates engagement ema text messages among substance using msm san francisco methods present analysis uses data collected project pilot study two month period participants received responded ema daily text messages inquiring study medication alcohol methamphetamine use baseline characteristics including demographics alcohol use substance use examined potential correlates engagement ema text messages logistic regression proportional hazards models results participants response rate ema text messages study period msm color significantly lower adjusted odds responding ema texts time compared white msm adjusted odds ratio college educated msm lower adjusted hazard week long discontinuation ema texts adjusted hazard ratio older msm higher adjusted hazard week long discontinuation ema texts adjusted hazard ratio conclusion differences engagement ema text prompts discovered msm different racial ethnic backgrounds ages education levels substance use variables correlated engagement text messages suggesting ema may useful research tool among actively substance using msm san francisco published elsevier inc
paper presents new approach develop remote practices systems engineering automatic control laboratories based easy javascript simulations ejss raspberry node ejss used create javascript html laboratory front end lets leachers students parametrize observe behavior controllers systems study web browsers tablets smartphones raspberry low cost single board computer charge running program closes control loop selected plant javascript laboratory web server hosts laboratory front end communicates controller finally javascript development runtime platform node used develop run javascript laboratory web sever within raspberry support communications laboratory front end server new strategy tested proportional integral differential pid controller vertical mono rotor plant provides low cost real time support controller friendly remote access mobile devices practices students ifac international federation automatic control hosting elsevier ltd rights reserved
background zno based varistors used surge protectors electrical circuits nonlinear polymer composites attractive potential applications low voltage varistors aim research study nonlinear behavior new composite containing zno polythiophene polyethylene methods sample disks consist zno polymer matrixes prepared using hot press method mpa degrees characteristics disks studied applying voltage structure products examined fesem ray diffraction results characteristics disks show resistivity varies nonlinearly different voltage increasing polythiophene content sample disks breakdown voltage decreases whereas nonlinear coefficient increases hand increasing press temperature effect breakdown voltage nonlinear coefficient addition increase working temperature leads lower breakdown voltage nonlinear coefficient conclusion polymer composite containing zno polyethylene polythiophene appropriate nonlinear behavior increase press temperature enhances nonlinear coefficient reduces breakdown voltage fesem images samples show pressing samples degrees affect composite structure
paper presents results investigation electrical circuits manufactured screen printing technology textile materials aim compare print quality line width thickness edge blurriness electrical resistance circuits printed using silver paste pont woven polyester non coated coated thin polyurethane polymeric layers morphology percentage silver electrical circuits analyzed scanning electron microscope sem energy dispersive ray eds spectrometer structure material precision printing direction strongly influence printed lines thin polymer layers close pores existing interspaces threads form surfaces low roughness minimize paste penetration substrate results demonstrate relatively uniform coverage conductive paste polyester coated polyurethane
much literature examined immigrants health canada less attention focused specifically life stress important yet understudied post migration challenge may lead poor coping strategies negative health consequences study pooled canadian community health survey cchs analyzed using multilevel logistic regression examine compositional effects individual level areal effects cma level reported high life stress separate models run immigrants non immigrants comparative purposes results reveal different ways select individual socioeconomic lifestyle factors affect life stress statistically significant yet small areal effect cma level life stress identified immigrants non immigrants comparing immigrants non immigrants factors smoking length residency canada mental health status found particularly informative predicting high life stress among immigrants healthy immigrant effect hie partially evident immigrants longer stay canada likely highly stressed recent arrivals areal effect variances high life stress minimal suggesting importance focusing individual level effects stress predictors
objectivest cell prolymphocytic leukemia pll rare aggressive cell neoplasm peripheral cell lymphoma otherwise specified ptcl nos also highly aggressive lymphoma two diseases often confused therefore aimed determine clinical pathological differences pll ptcl nos methodswe analyzed pll ptcl nos patients also compared clinical features pll ptcl nos leukemic presentation peripheral blood images biopsy specimens analyzed treatment responses determined via imaging modalities clinicopathological characteristics statistically compared resultst pll cells smaller size ptcl nos leukemic presentation moreover ptcl nos cells leukemic presentation smaller ptcl nos without leukemic presentation immunophenotypic patterns pll ptcl nos similar five year overall survival rates pll ptcl nos patients respectively significant differences found clinical manifestations prognoses pll ptcl nos leukemic presentation essentially equivalent characteristics conclusiont pll ptcl nos may share common biological clinical characteristics japanese patients
purpose study determine whether playing quest code computer game designed teach children asthma would help healthy children acquire knowledge attitudes towards asthma whether beneficial effects would maintained time sample consisted children four middle schools randomly assigned play quest code game nutrition serving control condition data collected knowledge attitude pre intervention post intervention follow four weeks later results revealed children played quest code knowledgeable positive attitudes peers control condition benefits maintained follow tests findings indicate effectiveness potential using quest code tool asthma education classroom setting
series multiarm star hydroxyl terminated polyesters mhps synthesized one pot method trimethylolpropane core molecule dimethylolpropionic acid type monomer epsilon caprolactone monocarboxylic acids modifiers influence different monocarboxylic acids viscosities polyesters films hardness studied found mhps prepared lauric acid displayed higher films hardness lower viscosities spectra mhps disclosed ring opening reaction epsilon caprolactone hydroxyl groups occurred nmr spectra demonstrated molecular structures mhps irregular due multiplicity reaction processes measured number average molecular weights mhps around mol pdi mhps exhibited lower viscosities range mpa solid contents possessed lower intrinsic viscosities compared linear polymers similar molecular weight cured films mhps exhibited excellent impact resistance adhesion flexibility high hardness displayed good thermal stability weight loss degrees solution viscosities mhps less mpa solid contents voc contents coatings obtained mhps low
diurnal animals better model seasonal affective disorder sad nocturnal ones previous work diurnal rodents demonstrated short photoperiod conditions brought depression like behavior however rodents large phylogenetic distance humans contrast nonhuman primates closely similar humans making excellent candidate sad model study made first attempt develop sad rhesus macaque macaca mulatto found short photoperiod conditions could lead monkeys display depressive like huddling behavior less spontaneous locomotion well less reactive locomotion addition depression related behavioral changes physiological abnormalities occur patients sad weight loss anhedonia hypercortisolism also observed sad monkeys moreover antidepressant treatment could reverse depression related symptoms including depressive like huddling behavior less spontaneous locomotion less reactive locomotion weight loss anhedonia hypercortisolism first time study observed sad symptoms rhesus macaque would provide important platform understanding etiology sad well developing novel therapeutic interventions future elsevier rights reserved
intake exhaust valves important components internal combustion engines used control inflow outflow gases valves subject thermal loading due high temperature pressure inside cylinder must tolerate limit material temperature sustainable optimal operation present study constitutes contribution predict temperature maps intake exhaust valves considering real conditions engine operation adequate subdivision valve used better assess effect part cylinder head therefore instantaneous heat transfer coefficient adiabatic wall temperature subdivision evaluated four stroke engine average values parameters calculated introduced boundary conditions finite element model implemented commercial code ansys cfx facilitate simulations runs proposed model apdl ansys parametric design language code developed extract thermal map application methodology used highlight temperature maps show region extreme temperature heat flux aim avoiding damage elsevier ltd rights reserved
backround aim study investigate dynamic thiol disulfide homeostasis untreated schizophrenia methods blood thiol disulfide homeostasis status reflects native thiol disulfide exchanges investigated untreated patients males females obtained results compared healthy controls blood serum native thiol total thiol tosh concentrations measured paired test half value difference native thiol tosh concentrations calculated disulfide bond amount results tosh concentrations found significantly lower patients untreated schizophrenia compared control group whereas disulfide levels significantly higher schizophrenia patients significantly higher tosh ratios significantly lower tosh ratio compared healthy individuals conclusions tosh amounts found insufficient untreated schizophrenia patients additionally according results study thiol disulfide homeostasis also disturbed shift disulfide bond formation side might affect neurotransmission processes known related many symptoms observed schizophrenia replacement thiol gap reduction excess amounts might positive effect supporting therapy schizophrenia patients
chiari malformation type defined descent cerebellar tonsils level foramen magnum traditional treatment symptomatic patients foramen magnum decompression fmd surgery intraoperative neurophysiological monitoring inm established surgical adjunct proposed reduce potential risk various surgical procedures though inm suggested helpful patient positioning determining optimal surgical extent fmd duroplasty laminectomy tonsillectomy shortcomings include prolongation anesthesia surgery well monetary costs multimodality inm including transcranial electric motor evoked potential tcmep routinely employed practices study evaluates efficacy multimodality inm fmd work retrospective analysis prospectively collected data twenty two fmd surgeries pediatric patients aged years performed center utilizing multimodality inm patients presented chiari malformation type presented syringomyelia underwent posterior fossa decompression fmd laminectomy accompanied additional cervical laminectomies duroplasty partial tonsillectomies tcmep somatosensory evoked potentials ssep monitored throughout procedure including positioning inm alarms correlated perioperative long term patient outcomes inm data remained stable operations three cases displayed significant attenuation monitoring signals concomitant patient positioning surgical table one case showed attenuation ssep data remained attenuated following repositioning another displayed altered tcmep concomitant positioning partially stabilized following repositioning resolved following bony decompression third case showed unilateral attenuation tcmep ssep data rectify closure three cases new neurological deficits observed post operatively multimodality inm useful fmd surgery particularly patient positioning tcmep attenuations may occur independent sseps clinical implications monitoring alerts yet defined need establish optimal cost effective monitoring protocol fmd
background surgical deactivation migraine trigger sites offers alternate treatment option patients recalcitrant headaches unresponsive medical therapies unable take medications aim article provide comprehensive review prevalence analysis migraine surgery trigger sites patients year study period methods retrospective review migraine patients underwent surgical decompression peripheral nerves data migraine surgery database maintained senior author reviewed preoperative variables included patient demographics migraine trigger sites whereas intraoperative variables included specific trigger site deactivation results overall female male patients underwent deactivation migraine headache trigger sites migraine surgery patients average trigger sites single trigger site operated migraine headache patients whereas patients multiple trigger sites nasal trigger site iii prevalent single trigger site affecting patients overall patients site component migraine complex concurrent occurrence trigger sites iii prevalent trigger site combination involving patients conclusion article offers prevalence information trigger sites provides simple classification ease communication among surgeons teams british association plastic reconstructive aesthetic surgeons published elsevier ltd rights reserved
present study investigates accuracy five different data driven techniques estimating oxygen transfer efficiency baffled chutes feedforward neural network ffnn radial basis neural network rbnn generalized regression neural network grnn adaptive neuro fuzzy inference system subtractive clustering anfis adaptive neuro fuzzy inference system fuzzy means clustering anfis fcm baffled apron chutes drops used channel structures dissipate energy flow baffled chute design effective energy dissipation aerating flow reducing nitrogen supersaturation close relationship energy dissipation oxygen transfer efficiency study aims determine aeration efficiency baffled chutes stepped wedge trapezoidal shaped baffle blocks performances ffnn rbnn grnn anfis anfis fcm models compared multilinear nonlinear regression models based comparisons observed data driven models could successfully employed modeling aeration efficiency baffle blocks available experimental data among data driven models ffnn model found best american society civil engineers
silver nanoparticles agnps extensively used antibacterial component numerous healthcare biomedical consumer products therefore adverse effects biological systems become major concern agnps shown absorbed circulation redistributed various organs thus great importance understand nanoparticles affect vascular permeability uncover underlying molecular mechanisms negatively charged mecaptoundeonic acid capped silver nanoparticle mua agnp investigated work vivo experiments mouse plasma revealed mua agnps caused plasma prekallikrein cleavage positively charged neutral agnps well ions effect vitro tests revealed mua agnps activated plasma kallikrein kinin system kks triggering hageman factor autoactivation using specific inhibitors aprotinin hoe demonstrated kks activation caused release bradykinin activated receptors induced shedding adherens junction protein cadherin biological perturbations eventually resulted endothelial paracellular permeability mouse retina intravitreal injection mua agnps findings work provided key insights toxicity modulation biomedical applications agnps
helping aggression core topics social psychology far abundant evidence violent media decreases helping increases aggression collected however recent theoretical empirical work demonstrated media may also increase prosocial outcomes decrease antisocial outcomes fact exposure media prosocial content increases accessibility prosocial thoughts empathy helping behavior decreases aggression aggression related cognition affect present article reviews research provides overview media exposure instigates helping reduces aggression
university california berkeley ucb developed preconceptual design commercial pebble bed fluoride salt cooled high temperature reactor fhr fhr baseline design mark fhr plant thermal reactor uses fluoride salt coolant solid coated particle pebble fuel design differs earlier fhr designs uses nuclear air brayton combined cycle designed produce electric base load electricity using modified general electric gas turbine peak electricity generation ability boost power output electric using natural gas firing uses direct heating power conversion fluid air primary coolant salt rather using intermediate coolant loop combining results computational neutronics thermal hydraulics pebble dynamics ucb developed detailed design annular core key functional features active normal shutdown cooling system passive natural circulation driven emergency decay heat removal system included computational models fhr validated using experimental data literature scaled thermal hydraulic facilities led set design criteria system requirements operate safely reliably three dimensional computer aided design models derived design criteria presented
constant changes occurring today teaching learning processes provide continuous improvement interaction information time globalization need streamlining time facilitate development new methods imparting knowledge new information technologies new forms learning occur adding greater dynamism information form learning optimizes time space known distance learning amply used many different areas distance education presents advantage facilitating teaching learning processes without face face interaction knowledge transmitted partly whole using technology fact technological innovation assumed vital role education looking achieve efficiency carrying various activities job market constantly requires investment new skills knowledge professionals operate equipment working tools successfully quality paper presents new system learning curricular unit circuit theory using desktop virtual reality software provides possibility understand relationship physical concepts electrical circuit direct alternating current computer simulations animations work developed demonstrate desktop prototype virtual electric manual vema applied engineering unit used enhance security resourcefulness using electrical equipment several interactive scenes developed illustrate idea using measurements instrumentation laboratory virtual environment range interactive learning environments presented menu first interactive experiment simulator circuit allows student analyze setting parallel series parallel resistive circuit series powered direct current second menu features simulator alternating current circuit demonstrates student perform analysis circuit resistors inductors capacitors third interactive experiment simulator three phase alternating current circuit fourth menu refers study transitional phenomena finally fifth menu interactive experiment related phenomena resonance vema offers students opportunity understand processes helping better discern procedures trains interact equipment vema prototype addresses issues highlights potential benefits using purpose experiment provide technical scientific knowledge order give student user adequate information training subject
paper focuses primary goal achieve emotional behaviour new version social robot probo ability enhance nonverbal communication children possible facial expressions eye tracking face face contact new social robot degrees freedom dof grouped five subsystems named generically eyes ears trunk mouth neck robotic head actuated using servo motors components manufactured using cheap flexible easy technologies order get social robot head able express emotions graphical user interface gui developed way facial expressions created sliders push buttons additionally investigated possibility controlling robot arduino board case using pre programmed learned algorithms robot getting semiautonomous level based usage various sensors able express six bagic emotions happiness sadness fear anger surprise disgust based feedback provided sensors robot react accordingly enhancing human robot interaction hri
osteoporosis common bone metabolic disease affecting nearly million people worldwide strong influence genetic components simultaneously adipogenesis osteogenesis two highly coordinated processes imperative maintenance bone quality quantity perturbation leads pathological conditions obesity osteopenia osteoporosis delineate adipogenic osteogenic connection total cases score recruited north india analyzing bone health status employing quantitative ultrasound qus bone densitometer genetic variants perilipin plin complement factor cfd adiponectin adipoq genotyped using pcr rflp arms pcr approach subjects plin cfd genotypes conferred nearly fold increased risk towards bone deterioration predicted rna secondary structures corroborated risk associated wild type allele allele carriers adipoq locus likely lower bone health fold haplotype analysis revealed adipoqvariants slight linkage disequilibrium nonetheless haplotype associated increased risk locus locus gene gene interaction models revealed greater likelihood bone deterioration conclusion certain variants adipogenic genes might serve potential biomarkers determining genetic predisposition towards bone loss north indian population emphasizing role impaired metabolism bone health elsevier rights reserved
energy crucial economic progress contemporary worldwide population increase demands greater energy generated conventional exhaustible resources energy price upsurge environmental concerns imperils sustainable economic growth nevertheless switching renewable energy produced naturally replenished resources promotes energy security likewise addressing issues global warming climate change paper aims exploring influence causal relation renewable energy overall type sustainable economic growth european union countries period notice mean share renewable energy gross final energy consumption mean share renewable energy transport fuel consumption thresholds respectively set directive estimating panel data fixed effects regression models results provide support positive influence renewable energy overall well type namely biomass hydropower geothermal energy wind power solar energy gross domestic product per capita however biomass energy shows highest influence economic growth among rest renewable energy types fact increase primary production solid biofuels increases gdp per capita besides cointegrating regressions set panel fully modified dynamic ordinary least squares regressions confirm positive influence related primary production renewable energies economic growth increase primary production renewable energies increases gdp per capita however results granger causality based panel vector error correction model indicate short run long run unidirectional causal relationship running sustainable economic growth primary production renewable energies supported conservation hypothesis
gait recognition challenging problem computer vision especially multi persons walk together called multi gait recognition multi gait recognition includes two aspects participant segmentation participant recognition paper propose segment participant hypergraph partition recognize participant multi linear canonical correlation analysis algorithm umcca firstly raw pixel areas obtained grid pixel area taken hypergraph vertex hog based detection tracking technology used calculate weight hyperedge segmentation umcca used extract gait features finally identity multi gait recognized experimental results demonstrate proposed method achieves good performance multi gait dataset
novel transparent roof made solid cpc compound parabolic concentrator photovoltaic thermal day lighting system presented combines solar system green building design system achieve excellent light control noon adjust thermal environment building high efficiency utilization solar energy could achieved modern architecture kind roof increase visual comfort building occupants also avoid building interior overheating dazzling noon caused direct sunlight transparent roof optical simulation software used track light path different incidence angles cfd computational fluid dynamics simulation steady state experiment taken investigate thermal characteristic device finally experimental system built efficiency light transmittance air heating power system tested real sky conditions elsevier ltd rights reserved
paper new approach introduced structural health monitoring offshore jacket platforms procedure uses measured ambient vibration responses corresponding readable natural frequencies mode shapes structural system since offshore platforms composed heavy topsides supported jacket structures participation first mode dominant direction response structure field excitations moreover ambient vibrations wave loads boat impacts excite first modes structure therefore difficult find higher modes pertinent frequencies use accelerometers data introduced innovative method research uses first fundamental frequencies mode shapes structure algorithm employs inverse vibration technique develop simple two three dimensional reference model monitoring health structure show efficiency proposed procedure case study carried models jacket type platform persian gulf namely spd finally uncertainty analysis performed due existence noises uncertainties input data collected accelerometers results indicate proposed method ability detect induced damages high level accuracy considering probable sources error elsevier ltd rights reserved
network intrusion detection systems widely used present day public private networks successfully detect cyber intrusions recent times plethora readily available hacking tools widened adversarial attack surface launch advanced malicious attacks entails need devise deploy stronger security solutions including countermeasures prevent detect deter attacks need efficient effective mechanism detecting network intrusions real time understated distributed pattern matching information sharing intrusion detection agents one approach towards identifying anomalous activity network paper novel distributed pattern matching approach proposed detecting malicious network activities first analyzing network traffic detector agents subsequently exchanging information subpattern among detector agents order holistically identify anomalous network activities detection effectiveness proposed approach studied using simulation conducted considering different pattern exchange hierarchies simulation results show approach yields high accuracies intrusion detection low false alarm rates
switched power electronic converters involve different control actions different system events local control strategy may developed reacts local information available component without communication different system components located far away real time purpose paper present low cost memory based control strategy boost converter control employed work based sliding mode hysteretic control strategy sliding manifold derived priori stored look table digital memory hardware proposed control implementation strategy low cost offers robust dynamic response used mitigate many disturbances system elsevier ltd rights reserved
within digital map service environment rapid growth spatial big data driving new requirements effective mechanisms massive online vector map tile processing emergence sql nosql databases resulted new data storage management model scalable spatial data deployments fast tracking better suit scenario high volume low latency network map services traditional standalone high performance computer hpc relational databases paper propose flexible storage framework provides feasible methods tiled map data parallel clipping retrieval operations within distributed nosql database environment illustrate parallel vector tile generation querying algorithms mapreduce programming model three different processing approaches including local caching distributed file storage nosql based method compared analyzing concurrent load calculation time online geological vector tile map service prototype developed embed processing framework china geological survey information grid experimental results show nosql based parallel tile management framework support applications process huge volumes vector tile data improve performance tiled map service
gas diffusion barriers gdb essential building blocks protection sensitive materials devices ambient gases like oxygen moisture work study mechanics gdbs processed atomic layer deposition ald demonstrate wide range ald grown barrier layers carry intrinsic mechanical tensile stress range mpa application gdbs top organic electronic devices derive critical membrane force sigma crit gpa angstrom corresponding layer thickness onset cracking delamination time evidence thicker gdbs would favorable efficient encapsulation statistically occurring particle defects thus reduce overall membrane force case levels sigma crit introduce additional compressively strained layers metals sinx thereby highly robust gdbs prepared top organic light emitting diodes crack delaminate even damp heat conditions degrees
starting point choosing theme belief specific physical education instructive activity dominant form communication nonverbal communication teacher pupils relationship study consisted sociological approach inquiry conducted middle school group pupils questionnaire comprised items prefigured open answers facilitate research middle school pupils dominant form expressing physical education lesson represented body movements expression energy information posture movement indices psycho somatic connection body soul
although several early intervention programs efficacious improving outcomes children autism treatment response variable leading families enroll child several interventions simultaneously knowledge effects combining different therapies limited critically important develop test predictions active ingredients different interventions interact child characteristics one another combined obstacle research agenda pre paradigmatic stage autism early intervention field many practices organized around seemingly irreconcilable vocabularies argue formalization explanatory structures informing different treatments based four parameters logical coherence falsifiability parsimony consilience provide conceptual lingua franca formulation testable hypotheses treatment individualization combination thus facilitating coherent rational approach research area
tear apophysis proximal tibia rare injury apophysal lesions mainly affects male adolescents years main causes concentric eccentric stress sport activity morbus osgood schlater seems predisposing factor date survey pathogenesis diagnostics treatment strategies literature research level iii studies well results affected patients mostly male type iii fractures frequently seen accompanying injuries missed treatment usually consists surgery means open reposition internal refixation recently also minimal invasi results mainly good good approximately reach old level activity almost one third patients develop mostly slight complication acute tear apophysis proximal tibia infrequent disease dislocated injuries standard procedure open reposition internal fixation lesions within knee particularly expected intraarticular fractures und must missed good good result expected correct treatment momentous complications together rare
purpose influence tactics prevalent workplace linked crucial outcomes career success helping behaviours authors argue sex role identity affects women choice influence tactics workplace receive positive performance ratings behaviours congruent gender role expectation furthermore authors hypothesize relationships may moderated occupational continuance commitment results suggest femininity negatively related use influence tactics overall relationship moderated occupational continuance commitment design methodology approach women working construction industry surveyed continuance occupational commitment sex role identity supervisors whose responses linked subordinates surveyed women influence tactics performance ratings findings results suggested femininity negatively related use influence tactics overall relationship moderated occupational continuance commitment results also showed women use influence tactics positively received terms performance ratings influence tactic congruent gender role expectations research limitations implications results current study suggest women equally likely use influence tactics tactics result positive perceptions performance feminine women general refrain using influence tactics unless driven stay given occupation receive positive results behaviours congruent society gender role expectations originality value past research mostly focused broad differences males females study shown nuanced differences accurately describe effects gender disposition sex role identity influence tactics also emphasizes importance occupational commitment boundary condition influences women step gender roles even though may penalized lower performance ratings
main aim study conduct preliminary analysis performance two conceptual designs integrate production potable water electricity salt used reverse osmosis pressure retarded osmosis pro electrodialysis produce potable water electricity salt respectively objective analysis observe relative positions pro integrated process affect five key parameters total dissolved solids tds potable water permeate rate total energy requirement units net delivered power salt potential simulated integrated design using previously validated mathematical expressions pro found net delivered power higher unit located pro unit sequence also results lower energy requirement producing potable water although permeate rate smaller rival sequence hand salt potential affected relative positions pro units elsevier rights reserved
matching software industry requirements academy significant challenge must accomplished benefit sectors mexico small medium size companies smes key software development way highly capable personal development high quality software products fundamental piece warranty permanency market context mexican organizations accreditation ensure quality software engineering smes software industry moprosoft norm undergraduate education institutions computer science informatics conaic document comparative analysis made understand coverage academic curricula higher education regarding software industry requirements based government norms establish accreditation
introduction irritable bowel syndrome ibs functional bowel disorder characterized chronic recurrent abdominal pain association defecation change bowel habits predominant disorder bowel habits ibs classified three main subtypes constipation predominant ibs ibs diarrhea predominant ibs ibs ibs alternating constipation diarrhea ibs linaclotide first class oral daily guanylate cyclase receptor agonist licensed symptomatic treatment moderate severe ibs adults review aims facilitate optimize clinical practices establishing common guidelines monitor patients ibs treated linaclotide methods group experts functional digestive disorders convened review efficacy safety linaclotide develop updated consensus report treatment patients ibs search performed english french spanish language articles pubmed basis articles identified initial document drafted addressing different issues frequently raised general practitioners specialists related prescription efficacy safety linaclotide document reviewed modified expert panel final text agreed upon validated results based evidence panel addressed following recommendations linaclotide indicated treatment moderate severe ibs adults recommended patients take linaclotide continuously sporadically patients warned risk diarrhea given choices concerning deal possible side effect absence tachyphylaxis potential risks implies linaclotide treatment maintained long periods time conclusions document seeks lay set recommendations identify key issues may useful clinical management ibs patients treated linaclotide
accumulating research indicates regular practice physical exercise beneficial human brain improvement academic achievement children prevention alzheimer disease elderly exercise appears beneficial across developmental spectrum recent work animal studies also indicates pregnant mother transfer benefits exercise gestation offspring brain exercising pregnant rats give birth pups better memory spatial learning well increased synaptic density investigate whether transfer pregnant mother child also occurs humans conducted randomized controlled trial measured impact exercise pregnancy neuroelectric response neonatal brain electroencephalography eeg show compared newborns mothers inactive pregnancy children exercising pregnant women born mature brains measured infant slow positive mismatch response spmmr electroencephalographic potential known decrease amplitude age spmmr reflects processes associated brain maturation via response sound discrimination auditory memory study children mothers exercised throughout pregnancy smaller spmmr children mothers remained sedentary results demonstrate impact regular exercise pregnancy development human fetal brain
paper pays attention predicting nonlinear bending behaviors functionally graded materials fgm infinite cylindrical shallow shells two parameter elastic foundation using two step perturbation method shells subjected uniform temperature rise temperature dependency constituents also taken account two ends shells assumed clamped pinned plane boundary conditions immovable governing equations derived based physical neutral surface concept high order shear deformation theory explicit expressions transverse load deflection obtained perturbation method numerical examples comparisons shown verify correctness present research solution method concluded fgm cylindrical shallow shells subjected uniform bending loadings bring snap buckling jump changes foundation enhance stability shells elsevier ltd rights reserved
responding association southeast asian nations asean community educational action teach common asean values curricula develop materials using united nations education sustainable development esd research aims train teachers develop interactive multimedia english second language esl courseware promotes asean culture literature esd uses addle instructional design analysis stage stage teachers enrolled master education esl course trained develop courseware computer programming integrated course teachers designed grade english syllabus matching required competencies asean content esd key thrusts design stage finalized interactive multimedia courseware syllabus promoted viewing reading skills grammar intercultural communicative competence development stage teachers courseware production courseware underwent readability content reliability implementation stage courseware underwent field pilot testing findings evaluation reflections interviews field testing show courseware scored strongly observable courseware promoted desired objectives use authoring software right training teachers limited background computer programming develop courseware
flexibility environmental perception artificial intelligence needed exist supporting software modules able automate creation specific language syntax make analysis relevant decisions based semantic functions according proposed approach implementation possible create couples formal rules given sentences case natural languages statements case special languages helping computer vision speech recognition editable text conversion system automatic improvement words developed approach achieved significantly improve training process automation artificial intelligence result give higher level self developing skills independently users base approach developed software demo version includes algorithm software code entire mentioned component implementation computer vision speech recognition editable text conversion system program ability work multi stream mode simultaneously create syntax based receiving information several sources
nephrologists serve many important functions hiv infected patients including identifying risks developing kidney disease detecting diagnosing kidney disease distinguishing antiretroviral induced kidney injury kidney disease setting antiretroviral therapy comanaging clinical course complications ckd preparing patients dialysis transplantation epidemiology kidney disease hiv informs functions describing natural history disease frequent occurrence high risk communities potential causes risk factors drive ckd hiv black race hypertension diabetes hiv viral replication low cell counts high viral load acquired immune deficiency syndrome defining conditions antiretroviral agents nephrotoxic potential prevalence risk factors population determines magnitude problem range low high recent research focuses kidney health hiv important links hiv viral replication glomerular filtration rate even patients normal kidney function reported review data provides foundation better understanding kidney disease hopefully better treatment patients hiv national kidney foundation inc rights reserved
aim study assess aerobic biodegradation four selected sulfonamides sulfanilamide sulfamethoxazole sulfadiazine sulfathiazole using water samples drawn highly polluted rivers additionally aimed identify factors significant effect process efficiency water samples collected brynica czarna przemsza rivers poland location approximately monthly intervals characteristic feature results presence significant differences rates sulfonamides biodegradation particular samples sulfonamide resistant biodegradation sulfamethoxazole whereas sulfathiazole biodegradable seasonal variations related microbial population changes significant effects sulfonamides biodegradation studied process highly inhibited wintertime decrease biodegradation rate river water could caused accidental water pollution industrial wastewater heavy metals increase salinity decrease turbidity elsevier rights reserved
using newly released globally available high resolution remote sensing data forest loss update assessment cross country determinants deforestation developing countries validate major determinants found previous literature generally based earlier time periods except role institutional quality agricultural trade hitherto relatively neglected found one main factors causing deforestation focusing effect international trade show countries different levels relative forest cover react differently shock agricultural exports value also emphasize taking countries development account may critical assessing global deforestation trends impact trade high countries still endowed large proportion forest cover lower countries smaller remaining forest cover finally estimate simple calibration exercise requirements cost effective redd policy compensating trade losses open economy exporting agricultural commodities endowed tropical forests conclude world increasing global demand might costly compensate totally thus offer right incentives developing countries limit deforestation elsevier ltd rights reserved
scoping review literature parenting programmes target promotion adolescent mental health conducted examine quality studies unique content programmes parents ethnoculturally diverse communities psycinfo web science searched april publications prior date august publications april august using specific keywords inclusion criteria hand search also conducted overall studies met inclusion criteria final data extraction included evaluations interventions targeted substance use early risky sexual activity behavioural problems eighteen studies described programmes targeting parents adolescents diverse ethnocultural communities quality studies assessed using marginally modified version downs black checklist downs black average quality assessment score addition two key themes reflected successful interventions emerged strengthening parent adolescent relationship communication importance community engagement designing implementing intervention findings indicate gaps service delivery parents adolescents ethnoculturally diverse communities limited number studies programmes targeting ethnoculturally diverse parents adolescents quality studies exist overall low given increasing diversity emphasis placed developing modifying programmes meet needs ethnoculturally diverse communities rigorous standardised efforts made evaluate programmes exist
apply machine learning principles predict hip fractures estimate predictor importance dual energy ray absorptiometry dxa scanned men women dual energy ray absorptiometry data two danish regions combined national danish patient data comprise women men years follow time original cohort men women twenty four statistical models built data points repeat cross validation validated remaining data points calculate area curve auc calibrate probability estimates best models retrained restricted predictor subsets estimate best subsets women bootstrap aggregated flexible discriminant analysis bagfda performed best test auc well calibrated probabilities following bayes adjustments bagfda model limited predictors among bone mineral densities bmd biochemical glucose measurements general practitioner dentist use achieved test auc men extreme gradient boosting xgbtree performed best test auc poor calibration higher probabilities ten predictor subset bmd biochemical cholesterol liver function tests penicillin use osteoarthritis diagnoses achieved test auc using xgbtree model machine learning improve hip fracture prediction beyond logistic regression using ensemble models compiling data international cohorts longer follow performing similar machine learning procedures potential improve discrimination calibration
purpose explore attitudes norms behaviors responses early life experiences protective factors influence pregnancy sexually transmitted infection risks perspectives current former foster youth inform development prevention strategies methods conducted semi structured individual qualitative interviews diverse sample current former foster youth aged years female average age years used theoretical thematic analysis systematically analyze data key themes related sexual health four categories norms attitudes responses early life experiences protective factors youth driven intervention ideas results participants reported range sexual experience levels varied sexual orientations also reported varied life experiences prior foster care detected several norms attitudes likely contribute risks early pregnancies sexually transmitted infections included one tell looking whether partner trustworthy sexually transmitted infection condoms necessary long term infrequent partners birth control used teen pregnancy inevitable event respect responses early life experiences youth frequently described difficulties dealing strong emotions context romantic sexual relationships many attributed difficulties early experiences biological family members foster care participants linked emotion regulation difficulties struggles trust appraisal effective communication impulsive behaviors youth also described variety protective factors felt helped prevent sexual risk behaviors improved lives respects finally participants endorsed factors likely improve intervention acceptability efficacy including open non judgmental group based environment involvement peer mentors inclusion caregiver caseworker training components conclusions trauma informed tailored intervention strategies address key norms attitudes provide broad based assertiveness emotion regulation skills likely effective strategies reduce risks teen pregnancies sexually transmitted infections among teens foster care group based interventions involve peer mentors caregiver caseworker components may especially acceptable effective teens foster kinship care elsevier ltd rights reserved
aims aim study assess empowerment intervention people schizophrenia methods randomized controlled trial carried november may involving participants diagnosed schizophrenia patients years diagnosed diagnostic statistical manual mental disorders dsm schizophrenia schizoaffective disorder outpatient mental health clinics jordan randomly assigned take part intervention consisted receiving weeks worth information booklets face face discussions receiving usual medication allocated treatment usual participants assessed baseline immediately intervention month follow primary outcome change helplessness score secondary outcomes psychiatric symptoms recovery rate empowerment quality life results study showed people schizophrenia intervention group showed improvement helplessness score immediately post intervention month follow reported significant improvements secondary outcomes conclusion study indicated empowering intervention effective intervention integrated treatment usual
efficient utilization satellite radio resource paramount importance satellite system performance economic competitiveness likely use band frequencies future satellite systems need better quality service qos complicate radio resource management process especially return link satellite system one connects user gateway hub paper discusses research themes part phd research carried supaero aimed developing radio resource management algorithms ultimately improve resource utilization qos return link interactive broadband satellite systems employing fade mitigation techniques band frequencies inputs optimization criteria resource management process identified various physical layer issues confront process also identified duration research years march end
objective replicating training program non verbal communication based theoretical framework interpersonal communication non verbal coding valuing aging aspects perspective active aging checking current relevance content assimilation index days mediate application method descriptive exploratory field study conducted three hospitals direct administration state sao paulo caters exclusively unified health system sus patients training lasted hours divided three meetings applied health professionals results revealed satisfactory satisfactory mediate content assimilation index conclusion program replication proved relevant updated setting hospital services remaining efficient healthcare professionals
objective many men diagnosed prostate cancer experience physical psychosocial late effects treatment interest preferences receiving information addressing common sequelae well understood examined long term survivors level interest whether differed based upon symptomatology preferred coping information source methods survivors years post diagnosis completed survey physical psychological health information interests preferences related late effects cancer treatment results half survivors reported interest information late effects treatment sexual health approximately quarter interested emotional health information survivors preferred receive information late effects treatment oncologists sexual health information primary care providers pcp oncologist written online resources emotional health information pcp information needs commonly reported among men poorer domain specific health functioning conclusion long term survivors report significant interest receiving information physical sexual emotional health practice implications medical providers caring men inquire survivors information needs future intervention efforts consider delivers information dependent upon type dysfunction reported elsevier ireland ltd rights reserved
fuel consumption viewed fundamental problem boats operate sea long time without need refueling paper hybridization conventional medium sized boat reduce fuel consumption considered purpose optimal sizes main components electric motor internal combustion engine battery generator calculated via constrained particle swarm optimization algorithm considers accelerating speeding expectations constraints furthermore new fuzzy thermostat controller whose parameters tuned via optimization proposed manage energy flow main components estimate fuel consumption backward forward simulation approach based quasi static maps diesel engine electric motor employed moreover boat resistance forces calculated typical driving cycle displacement planning modes simulation results reveal hybridization conventional boat leads reduction fuel consumption without violating performance constraints
sequential monte carlo smc implementation probability hypothesis density phd filter suffers low computational efficiency since large number particles often required especially large number targets dense clutter order speed computation algorithmic framework parallel smc phd filtering based multiple processors proposed algorithm makes full parallelization four steps smc phd filter computational load approximately equal among parallel processors rendering high parallelization benefit multiple targets dense clutter parallelization theoretically unbiased provides result serial implementation without introducing approximation experiments multi core computers demonstrated parallel implementation gained considerable speedup compared serial implementation algorithm elsevier rights reserved
studies trans prejudice prejudice transgender people conducted western countries current study explored trans prejudice sample heterosexual college students people republic china also examined relationship gender self esteem importance gender one self identity trans prejudice results indicated men reported trans prejudice women women men reported violence toward teasing discomfort trans women compared trans men gender self esteem significant predictor trans prejudice men women results suggest predictors trans prejudice chinese people may similar predictors found western samples however differences may due cultural factors membership collectivistic versus individualistic society
noninvasive techniques nail imaging would useful confirming diagnosis monitoring treatment response microscopic level patients nail psoriasis however use ultrasound high resolution magnetic resonance imaging nail evaluation limited optical coherence tomography oct produces high resolution images transversal tissue sections represents optimal approach study nail study used multibeam oct instrument produce speckled variance oct oct blood flow images used measure degree change successive scans nail changes inflammation response therapy evaluated year old female patient psoriasis severe acrodermatitis continua hallopeau hands treated weeks adalimumab administered subcutaneously every week prednisone administered orally daily oct provided detailed assessment nail structures relation inflammation psoriatic tissues restoration normal anatomy nail apparatus apparent following adalimumab treatment oct evaluation correlated clinical appearance oct may diagnostic role provide objective tool assess clinical subclinical inflammation nail psoriasis
paper addresses road toll pricing capacity investment problem congested road network multicriteria decision making framework goal programming approach used following four major goals considered cost recovery service level environmental equity multiobjective road toll pricing capacity investment problem formulated bilevel goal programming model upper level model aims minimize deviations stated goals given priority ranking goals lower level road users route choice equilibrium problem simulated annealing based solution algorithm developed solve proposed model numerical results show priority structure goals significantly affect road toll pricing capacity investment decisions simulated annealing based solution algorithm outperforms sensitivity analysis based solution algorithm terms solution quality proposed methodology provides avenue understanding trade offs among conflicting objectives designing financially environmentally sustainable transportation system
modeling wave propagation microstructured materials able account various scales microstructure based proposed new exponential expansion method obtained multiple explicit exact traveling wave solutions strain wave equation describing different types wave propagation microstructured solids solutions obtained paper include solitary wave solutions topological kink singular kink non topological bell type solutions solitons compacton cuspon periodic solutions solitary wave solutions rational functions shown new exponential method help symbolic computation provides effective straightforward mathematical tool solving nonlinear evolution equations arising mathematical physics engineering faculty engineering shams university production hosting elsevier open access article license http creativecommons org licenses
deep learning techniques sentiment analysis become popular provide automatic feature extraction richer representation capabilities better performance traditional feature based techniques surface methods traditional surface approaches based complex manually extracted features extraction process fundamental question feature driven methods long established approaches yield strong baselines predictive capabilities used conjunction arising deep learning methods paper seek improve performance deep learning techniques integrating traditional surface approaches based manually extracted features contributions paper sixfold first develop deep learning based sentiment classifier using word embeddings model linear machine learning algorithm classifier serves baseline compare subsequent results second propose two ensemble techniques aggregate baseline classifier surface classifiers widely used sentiment analysis third also propose two models combining surface deep features merge information several sources fourth introduce taxonomy classifying different models found literature well ones propose fifth conduct several experiments compare performance models deep learning baseline use seven public datasets extracted microblogging movie reviews domain finally result statistical study confirms performance proposed models surpasses original baseline score authors published elsevier ltd
virtual remote laboratories commonly used engineering education mainly designed using java programming language popular widely used learning management system moodle paper describes development virtual laboratory using easy java simulations software tool integration learning tool moodle virtual laboratory demonstrates easy java simulations moodle used optimal control theory education example well known brachistochrone problem solution
evaluated differences major markers cardiovascular risk inflammatory bowel diseases ibds controls systematic review meta analysis searched pubmed embase cochrane databases literature comparing risk markers ibds controls overall mean carotid intima media thickness cimt flow mediated dilation fmd carotid femoral pulse wave velocity cfpwv difference patients ibds control groups calculated twenty eight studies included meta analysis including studies data cimt studies reporting fmd studies cfpwv compared controls patients ibds showed significantly higher cimt standardized mean difference smd confidence interval significantly lower fmd smd significantly increased cfpwv smd analyzing subgroups ulcerative colitis crohn disease results still significant except cimt findings support current evidence elevated burden patients ibd support clinical utility markers subclinical atherosclerosis management patients
last decade new surgical treatment modality developed frontal secondary headache based assumption trigger pain entity entrapment peripheral sensory nerves surgery entails procedure endoscopic approach used decompress supraorbital supratrochlear nerve branches entrapped periosteum region corrugator supercilii muscle candidates surgery define headache moderate severe persistent daily pressure tension localized frontal area sometimes accompanied symptoms nausea photophobia mimicking primary headache migraine created step step screening algorithm used differentiate patients highest chance successful surgical decompression published data regarding type surgery demonstrate long lasting successful outcomes adverse effects minor article reviews discusses surgeon perspective decompression surgery secondary headache attributed supraorbital supratrochlear nerve entrapment
aim work assess role polymorphisms belonging genes involved regulation ionic homeostasis caucasian patients meniere disease recruited patients definite meniere disease controls control group without lifetime history vertigo overlapping patients age rate hypertension validated positive results caucasian subjects selected european general population control group clinical history migraine hypertension collected genomic dna characterized panel snps encoding proteins involved ionic transport found higher rate migraineurs subjects compared group four snps displayed differences patients compared group controls sik gene slca values chi squared test genotype frequencies respectively slca gene encodes exchanger sik gene encodes salt inducible kinase enzyme associated atpase function validation control group displayed strongly associated respectively data support hypothesis genetically induced dysfunction ionic transport may act predisposing factors develop
since first description celiac disease ced samuel gee later miraculous discovery bread responsible condition following world war europe exponential growth knowledge regarding ced thought knew everything know disease however offering new challenges presentation significantly morphed years cases overt gastrointestinal symptoms malnutrition atrophic villi duodenal biopsies largely extraintestinal subtle mild symptoms along changes unexpectedly new parallel entity appeared years ago gaining ground called nonceliac gluten sensitivity impro per name actually referred wheat intolerance syndrome given role gluten cases far demonstrated implication immune involvement suggested term sensitivity still unfounded lastly wheat offender also immunoglobulin mediated allergy whose presence must also evaluated ruled selected cases practicing physician therefore challenged task discerning patients need assessed one disorders review aims providing updated critical reassessment entities
rapidly growing internet traffic energy efficient operation wdm networks sleep enabled routers increasing interest however network security provide guaranteed communications would still desirable ensure certain fraction bandwidth assured routers put sleep using software control paper presents energy minimized wdm network using mixture sleep enabled non sleep enabled router cards certain percentage network bandwidth guaranteed offered traffic mixed configuration also motivated fact always traffic demand node pair time even though traffic node pairs may fluctuate low levels implies need non sleeping router cards time another motivation mixed configuration course migration today networks non sleep enabled cards future networks sleep enabled cards non sleep enabled network devices quickly abandoned gradually replaced also causes network situation mixed router card types design wdm network sleep enabled non sleep enabled router cards used propose mixed integer linear programming milp model jointly minimizes energy consumption router cards guaranteeing secured fractional bandwidth node pairs modified milps subsequent port channel association also proposed along efficient heuristic algorithms perform almost well joint milp approaches performance approaches studied simulations wide variety networks
quaternion ordered combination four real numbers also expressed sum scalar vector three dimensional euclidian space quaternion algebra allows division vectors since current vector algebra allow division vectors many branches mechanics vectoral quantity falls denominator expression general tendency use magnitude rather vector character vector division defined quaternion algebra becomes possible redrive equations vector quantities denominators study basic equations stress strength materials reviewed according rules quaternion algebra shown new point view brings powerful consistent system normal stress becomes scalar quantity area moment inertia cross section becomes vectoral quantity direction shearing stresses change becomes consistent convention especially torsion problems striking results obtained shear flow
background aims despite excellent efficacy direct acting antivirals daa reported clinical trials virological failures occur often associated development resistance associated substitutions rass study aimed characterize presence clinically relevant rass classes real life daa failures methods virological failures analyzed daa treated patients pegylated interferon ribavirin pegifn rbv without hcv treatment experienced cirrhotic observed sanger sequencing nsa nsb performed home made protocols failure whenever possible baseline results majority virological failures relapsers breakthroughs non responders ras prevalence varied according ifn rbv use daa class failure type hcv genotype subtype ifn group ifn free highest prevalence nsa rass compared rass ifn without nsb rass ifn without sofosbuvir failures ifn free group rass higher breakthrough non responders relapsers daa classes showed multiclass resistance including nsa failures furthermore patients baseline rass always confirmed failure conclusions failure setting ras prevalence remarkably high genes partial exception nsb whose limited resistance still higher previously reported multiclass resistance advocates hcv resistance testing failure three genes best second line therapeutic tailoring
paper presents framework human detection based joint component model using extended feature descriptors framework provides two contributions handling partially occluded problem pedestrian detection crowded environments first presents feature descriptors based extension two well known feature descriptors accommodation partially occluded pedestrian detection feature descriptors use multiple scale blocks based histograms oriented gradients mhog parallelogram based haar like feature phf proposed improving accuracy detection system result using mhog extensive feature space allows obtaining highly discriminated features supports robust detection hand phf adaptive shape human limbs detection pedestrians contribution also presents special data structures store image intensities image gradients using integral image method helpful fast computation feature descriptors second joint component model human detection proposed training detecting pedestrians crowded scenes proposed detection method based fusion boosting technique support vector machine svm presented svm known one efficient learning models classification advantage boosting strong classifier based combination set weak classifiers however performance boosting depends kernel element classifier method based extended feature descriptors joint component model helpful constructing efficient classification experimental results demonstrate method pedestrian detection outperforms current methods crowded situations variety outdoor environments elsevier rights reserved
objective inappropriate sexual behaviors isbs represent challenging stressful manifestations dementia highly burdening patients families healthcare providers nevertheless isbs far attracted limited clinical scientific interest compared neuropsychiatric symptoms occurring dementing illnesses authors aimed systematically investigate prevalence characteristics isbs population patients dementia attending memory clinic methods cross sectional study individuals dementia attending memory clinic consecutively enrolled january february participating subjects underwent detailed medical history collection comprehensive cognitive functional neuropsychiatric assessment presence isbs previous days investigated adoption hoc questionnaire administered informants logistic regression model carried identify sociodemographic clinical variables associated isbs results patients women dementia recruited study isbs detected patients total sample logistic regression model showed male sex anxiety statistically significantly associated presence isbs conclusion isbs represent common manifestations dementing illnesses given significant burden isbs patients families impact care management occurrence always investigated clinical care individuals dementia purpose specific screening assessment tools properly designed validated
rapid growth construction megaprojects worldwide triggered growing number papers published area past two decades suggesting construction megaproject management become emerging area field construction engineering management cem study aims investigate status trends megaproject research conducting structured literature review total relevant articles identified eight peer reviewed cem journals analyzed based number articles published annually institutional regional contributions citations categorization research interests methodologies analysis results indicated developed countries united kingdom united states australia enjoyed significant advantages megaproject research greater experience megaproject research developing countries russia india turkey vietnam remains weak lacking results also revealed many theory based findings reported five subareas namely construction site management cost schedule management risk analysis management innovation utilization information technology leadership professional development subareas organization stakeholder management project planning procurement project monitoring control remain promising domains future research particularly developing countries yet develop research tradition incorporating complexity theory institutional theory theoretical foundation subareas develop megaproject research strengthened global collaboration future
two centuries ago james parkinson provided first medical description parkinson disease later refined jean martin charcot mid late century include atypical parkinsonian variants also termed parkinson plus syndromes today parkinson disease represents second common neurodegenerative disorder estimated global prevalence million conversely atypical parkinsonian syndromes encompass group relatively heterogeneous disorders may share clinical features parkinson disease uncommon distinct clinicopathological diseases decades scientific advancements vastly improved understanding disorders including improvements vivo imaging biomarker identification multimodal imaging visualization structural functional brain changes especially important allows window underlying pathophysiological abnormalities article first present overview cardinal clinical neuropathological features synucleinopathies parkinson disease lewy body spectrum disorders well multiple system atrophy tauopathies progressive supranuclear palsy corticobasal degeneration comprehensive presentation wellestablished emerging imaging biomarkers disorder discussed biomarkers following imaging modalities reviewed structural magnetic resonance imaging mri using susceptibilityweighted sequences volumetric voxel based morphometric analyses well mri derived visual signatures diffusion tensor mri assessment white matter tract injury microstructural integrity proton magnetic resonance spectroscopy quantifying proton containing brain metabolites single photon emission computed tomography evaluation nigrostriatal integrity assessed presynaptic dopamine transporters postsynaptic dopamine receptors cerebral perfusion positron emission tomography gauging nigrostriatal functions glucose metabolism amyloid tau molecular imaging well neuroinflammation myocardial scintigraphy dysautonomia transcranial sonography measuring substantia nigra lentiform nucleus echogenicity imaging biomarkers using multimodal approach may aid making early accurate objective diagnostic decisions highlight neuroanatomical pathophysiological mechanisms well assist evaluating disease progression therapeutic responses drugs clinical trials
open source software project openphase allows three dimensional simulation microstructural evolution using multiphase field method core modules openphase implementation well parallelization distributed memory setting presented especially communication load balancing strategies discussed synchronization points avoided increased halo size additional layers ghost cells allow multiple stencil operations without data exchange load balancing considered via graph partitioning sub domain decomposition results presented performance benchmarks well variety applications grain growth polycrystalline materials including large number phase fields well alloy solidification elsevier rights reserved
paper presents time dependent simulation three phase squirrel cage induction motor using comsol multiphysics software simulation made constant rotational velocity adjusted nominal one tested motor course stator currents currents rotor bars rotor ring course motor torque shown finite element method model external electrical circuits meshing also shown values stator current motor torque compared values motor catalogue seen simulation results comsol match catalogue values rather well
objectives estimate billed charges generated university hospital patients seen outpatient senior clinic month period estimate average billed charges per geriatric patient generated month period design retrospective analysis setting hospital based outpatient senior clinic university medical center participants outpatients aged older measurements total inpatient outpatient professional fee charges generated senior health center shc patients estimated month period use billing data professional hospital billing systems estimate multiplier effect average charges per shc patient per year analysis focused professional charges generated directly shc professional fees hospital charges generated secondary referral inpatient outpatient results one thousand nine hundred ninety eight patients seen shc month period every billed professional charges shc billed elsewhere hospital system geriatric medicine professional charges generated shc patients month period totaled month charges rest hospital system patients included hospital inpatient charges departments hospital outpatient charges ancillary plus technical including facility fees shc professional fees departments thereby producing multiplier factor average overall charges per geriatric patient per months totaled included hospital inpatient hospital outpatient professional fees generated average hospital charges per shc patient per months average hospital charges generated per established shc patient per months average hospital charges new shc patient per months average professional charges per patient per months conclusions study provides reasonable estimate substantial multiplier flow effect senior clinic parent medical center although senior clinics may cost center viewed isolation clinics actually revenue generators viewed perspective entire health system
investigation paper set dimensional nonlinear schrodinger maxwell bloch nls equations describes optical pulse propagation erbium doped fibre employing hirota method symbolic computation obtain one two soliton solutions prove interactions two solitons elastic asymptotic analysis soliton solutions figures plotted show one soliton interaction two solitons find decrease frequency shift resonance make angle propagation directions amplitudes two solitons bigger implying change amplitudes two solitons closely related propagation directions two nls solitons
effects feeding system libitum restricted restriction programs daily weekly base evaluated commercial crossbred rabbits housed individually weaning slaughter age first three weeks restricted rabbits received libitum intake according two feeding curves daily group weekly increments week average group restriction period feeding system affected cttad crude protein restricted compared libitum rabbits restriction dry matter ether extract adf mad lower previously restricted rabbits compared always fed libitum first period feed restriction reduced daily weight gain feed intake empty body lipid energy contents compared libitum feeding second period previously restricted rabbits showed higher daily weight gain lower feed conversion besides higher empty body lipid energy contents compared rabbits fed libitum whole trial feed restriction reduced mortality tended reduce feed intake feed conversion well retention restriction program effects restriction period feeding period rabbits submitted week week restriction exhibited higher weight gain feed intake lower feed conversion compared restricted daily base whole trial rabbits showed higher feed consumption excretion rabbits later slaughter age increased final live weight feed conversion dressing percentages dissectible fat hind leg muscle bone ratio empty body lipid energy contents besides body retention excretion conclusion regardless restriction program mild feed restriction libitum first period improved rabbit health status reduced environmental pollution fattening sector without impairing growth performance slaughter results carcass traits elsevier rights reserved
paper presents method friction compensation linear electric motor model loop suspension test rig suspension consists numerically modeled spring damper inputs suspension motion linear motor force controlled using force sensor track output numerical model method uses coulomb friction model applies feedforward step signal velocity zero crossing occurs velocity zero crossing estimation achieved using algorithm based measured feedback velocity force experimental results indicate reduction force tracking error caused coulomb friction leading improved test rig accuracy
shake tables essential facilities laboratory evaluating structural performance subject vibration excitation paper improve time waveform replication accuracy electro hydraulic shake tables ehsts improved feedforward inverse control algorithm adaptive refinement proposed ehst system transfer function stable inverse model firstly estimated designed multi step recursive extended least squares algorithm zero magnitude error tracking controller technology respectively reduce side effect model identification errors estimated actual system system model corrector identified based previous estimated ehst model inverse corrector obtained constitute improved feedforward inverse controller ific cascading inverse corrector previous designed inverse model adaptive refinement controller using least mean square algorithm applied ific controlled system cope system uncertainties nonlinear effects therefore proposed algorithm combines merits feedforward inverse control adaptive control finally help xpc rapid prototyping technology experiments conducted real uniaxial ehst system experimental results demonstrate proposed algorithm exhibits better tracking accuracy conventional controllers shake tables
work proposed new real time monitoring system distribution transformer communication zigbee network obtains voltage current power energy frequency loads connected distribution transformer information collected measurements send server zigbee network safe information new real time system build wireless network low energy consumption large transmission distance enough conditions work urban distribution electric network system make possible low cost infrastructure task save electric magnitude well possible diagnostic electrical network
recent years image encryption algorithms developed rapidly order ensure security image transmission assistance previous work paper proposes novel chaotic image encryption algorithm based self adaptive model feedback mechanism enhance security improve efficiency different existing methods permutation performed self adaptive model initial values iteration generated novel way make distribution initial values uniform unlike schemes strength feedback mechanism stage diffusion piecewise linear chaotic map first introduced produce intermediate values sake resisting differential attack security efficiency analysis performed measure scheme comprehensive simulations considering key sensitivity key space encryption speed resistance common attacks especially differential attack
objective examine physician eye contact patient understanding adherence methods secondary analysis national institute aging videotapes physician elder patients two visit types routine anxiety provoking conducted self reports understanding adherence used history taking segments qualitatively quantitatively analyzed relationships understanding adherence results qualitative analysis showed two salient elements frequency type brief sustained verbal synchronicity commonly invoked conjoint unfolding three communication elements looking listening talking may salient patient outcomes despite differing patterns routine anxiety provoking visits statistical analyses showed patient understanding adherence ratings similar sample population comprising two visit types significant correlations elements understanding adherence found conclusions salience patient centered communication shown prior research present findings broaden significance including verbal synchronicity methodological limitations may account significant correlations patient outcomes practice implications using suggested framework operationalizing elements including verbally synchronous communication may facilitate patient centeredness positive implications patient understanding adherence elsevier ireland ltd rights reserved
recent discovery association low serum melatonin levels relapse multiple sclerosis opens new horizon understanding pathogenesis disease skin main organ sensing seasonal changes duration sunlight exposure level melatonin production dependent light exposure molecular mechanisms connecting peripheral skin sensing light exposure developing brain inflammation investigated hypothesize connection reaction skin seasonal changes sunlight exposure risk seasonal changes light exposure cause peripheral skin inflammation production cytokines subsequent inflammation brain skin genetically predisposed individuals cytokines attract memory cutaneous lymphocyte associated antigen cla lymphocytes maintain local inflammation inflammation resolved cla lymphocytes return circulation eventually migrate brain brain lymphocytes may initiate inflammatory response observation increased chemokine ligand ccl sera supports involvement skin pathogenesis importance data ccl chemokine released activated keratinocytes upregulated inflamed skin propose high serum levels ccl result skin inflammation due exposure seasonal changes sunlight future studies determine whether ccl serum level correlates seasonal changes sunlight exposure exacerbation skin inflammation
heterogeneous catalytic hydrogenation gaseous carbon dioxide methanol important reduction reaction chemical process engineering renewable energy industry emerging green chemistry provides means harness surplus electrical energy convert pollutant emitted greenhouse gas useful building block biofuel industrial operating scale multifunctional copper zinc catalysts various supporting substrates cza alumina commonly used due high selectivity conversion work post hartree fock density functional theory dft calculations carried assess thermodynamics elucidate pathway leading formation methanol realistic spinel type tri metallic materials firstly commercial like zno alo synthesised via precipitation characterised obtain active sites structure modelling powder ray diffraction xrd brunauer emmett teller bet surface area measurement scanning transmission electron microscopy sem tem energy dispersive ray spectroscopy eds performed subsequently gibbs free energy enthalpy entropy chemical equilibrium constants direct methanol synthesis competing reverse water gas shift rwgs reaction temperatures degrees pressures bar evaltated using initio quantum chemistry method ccsd aug pvqz investigate kinetics mechanistic pathway scheme established intermediates constructed whereas physical chemical adsorption desorption energies geometries barriers rates adsorbate elementary steps calculated using plane wave dft results demonstrate formate precursor route predominates respective transition state activation energies lower thus proposed form hcoo hcoo hcooh cho cho species elsevier rights reserved
filtering potential policy issues large range possibilities relatively small list agenda items allows organisation power influence within policy sector examined study investigated power influence health policy agenda setting one state australia victoria years actors seen influential predominantly medically trained working academia health bureaucracies public teaching hospitals research supports elite model health policy agenda setting outcomes dependent structured interests within policy field however corporate elite profession influential frontline service providers indicated location influentials large prestigious organisations politicians professional associations unions less well represented consumer community groups virtually absent sharp increase economists nominated influentials subsequent decrease influentials medical training relates perceived real shift influence medical profession senior health bureaucrats economic concerns appear shaping visible health policy agenda increased number influentials economics training also apparent ability shape issues influentials adding agenda items corporate elite medicine remains powerful range concerns effectively limited cost containment cost reduction better planning efficiency limiting concerns occurs within international policy context general trends globalisation emphasis neo liberal economics impact direction health policy individual countries elsevier science ltd rights reserved
rapid identification mycotoxins deoxynivalenol aflatoxin agricultural commodities ongoing concern food importers processors sophisticated chromatography based methods well established regulatory testing food safety authorities techniques exist provide rapid assessment traders study advances development mid infrared spectroscopic method recording spectra little sample preparation spectral data classified using bootstrap aggregated bagged decision tree method evaluating protein carbohydrate absorption regions spectrum method able classify maize samples european union regulatory limit deoxynivalenol gkg first time peanut samples gkg aflatoxin subset model revealed dependency variety type fungal infection employed crc sbl maize varieties could pooled model reduction classification accuracy samples infected fusarium verticillioides removed leaving samples infected graminearum culmorum dataset improving classification accuracy gkg classification threshold deoxynivalenol maize performed even better accuracy assumed due larger number samples around threshold increasing representativity comparison established principal component analysis classification consistently showed overlapping clusters confirmed superior performance bagged decision tree classification
due increase elderly population research healthcare monitoring ambient assisted living technology crucial provide improved care time contain healthcare cost among existing systems none robust system act bridge different systems facilitate knowledge sharing empower detection prediction capabilities systems use data knowledge similar systems due complexity involved sharing data storing information also challenge due high volume sensor data generated sensor proposed heal model platform provides services developers leverage previously processed similar data corresponding detected symptoms proposed architecture cloud based provides services input sensors internet things devices context providers ultimate goal system fill gap symptoms diagnosis trend data order predict health anomalies accurately quickly
common expectation analytical rotations factors components aiming simple structure allow dimensions intercorrelated manifest variables identified high degree certainty recently presented counter model rotation complex structure supported large number investigations fundamentally calls assumption question paper examines claimed advantage rotation complex structure aid artificially generated data structures whose components predetermined similarity comparisons possible show rotation complex structure provides interpretable realistic solutions elsevier ltd rights reserved
cam mechanisms integral parts many products used many applications combustion engines milling machines fitness machines suggested range applications important issue article configuration mechanism comprising flat faced follower pressed surface radial cam coil spring studied basis known lifting function results previous work new cam profile proposed lifting functions polynomial character particularly cubic polynomial fifth degree polynomial seventh degree polynomial studied subsequently proposed methodology calculation torque according desired angular velocity cam methodology used choosing suitable electric motor proper selection coil springs spring preload determined intention avoid rebound follower cam surface based analytical analysis new measuring stand proposed future analytical results complemented experiment authors published elsevier ltd
solar photovoltaic system known one outstanding new renewable energy systems achieving nearly zero energy building nzeb continuous deployment solar system urban environments crucial estimate rooftop solar potential urban areas however high rise buildings abound always suitable solar installation therefore important accurately estimate available rooftop area considering shadows surrounding buildings reliable rooftop solar potential estimation therefore study proposed method estimating rooftop solar potential analyzing available rooftop area hillshade analysis toward end rooftop solar potential estimated following hierarchical process calculation physical potential calculation geographic potential iii calculation technical potential accurate estimation rooftop solar potential geographic potential available rooftop area explored detail analyzing shadow based location sun hillshade analysis applying proposed method gangnam district seoul south korea study estimated physical geographic technical potentials hourly monthly annual bases overall physical geographic technical potentials gangnam district found respectively rooftop solar potential results used establishing solar policies analyzing different levels rooftop solar potential hourly monthly annual bases elsevier ltd rights reserved
examined self determination theory sdt weight loss hypothesized diabetes prevention program dpp intervention would result increase autonomous regulation motivation participants higher perceived educators supporting sdt defined needs would lose weight support health information nutrition exercise shine study data analyzed shine randomized controlled dpp translation trial years telephonic primary care staff autonomous motivation males increased significantly females showed change males high females lost weight however significance relationships varied time participants perceived educators supportive psychological needs lost weight especially males however effect support weight loss mediated change autonomous motivation educator support relevant male weight loss future research might develop interventions enhance autonomous motivation educator support understand change pathways
ankylosing spondylitis chronic autoimmune disease affecting spine involvement cervical spine atlanto occipital temporomandibular cricoarytenoid joints leads difficulty airway management securing airway conventional laryngoscopy report case severe ankylosing spondylitis severe restriction neck movements limited mouth opening conventional laryngoscopy endotracheal intubation impossible patient movement atlanto occipital join decided use king vision video laryngoscope intubation proved great use publishing services elsevier behalf egyptian society anesthesiologists
background objectives association fruit vegetable intake risk metabolic syndrome mets elucidated fully particularly menopausal status method study design study population women aged years participating korea national health nutrition examination survey definition mets components based modified national cholesterol education program adult treatment panel iii ncep atp iii koreans dietary data assessed hour recall results fruit intake inversely related risk high blood pressure mets total vegetable consumption inversely associated mets risk combined fruits inverse association observed even features high triglycerides low hdl cholesterol well mets assessing women menopausal status revealed inverse association mets risk found postmenopausal women greater total vegetables total intake aor trend aor trend respectively analysis regarding mets features showed inverse association total vegetables total intake observed high risk postmenopausal women fruits intake inversely associated high risk premenopausal women aor trend conclusion results suggest fruit intake inversely associated high premenopausal women greater dietary intake vegetables total may protect risk mets particularly postmenopausal women
present paper aims providing objective narrative review existing non pharmacological treatments spasticity whereas pharmacologic conventional physiotherapy approaches result well effective managing spasticity due stroke multiple sclerosis traumatic brain injury cerebral palsy incomplete spinal cord injury real usefulness non pharmacological ones still debated performed narrative literature review contribution non pharmacological treatments spasticity management focusing role non invasive neurostimulation protocols ninm spasticity therapeutic options available physicians include various pharmacological non pharmacological approaches including ninm vibration therapy aimed achieving functional goals patients caregivers successful treatment spasticity depends clear comprehension underlying pathophysiology natural history impact patient performances even though studies aimed validating non pharmacological treatments spasticity fostered growing evidence supporting usefulness non pharmacologic approaches significantly helping conventional treatments physiotherapy drugs reduce spasticity improving patient quality life hence non pharmacological treatments considered crucial part effective management spasticity elsevier ltd rights reserved
state feedback technique gain matrix well known method pole assignment linear system technique could encounter difficulty eliminating steady state errors states introducing integral element effectively eliminate errors state feedback fractional integral control proposed work pole placement linear time invariant system proposed method yields simple gain formulae paper presents derivation design formulae method applied stabilise inherently unstable inverted pendulum cart system simulation experimental results show effectiveness proposed method set point tracking disturbance rejection stabilising inverted pendulum comparison results obtained applying achermann formula also presented
objective aim study measure possible impacts salutogenic lifestyle education programme wellness academic outcomes group socioeconomically disadvantaged students first year higher education setting university eastern cape province south africa methods mixed methods approach utilised assess relationship wellness academic outcomes data gathered using wellness questionnaire higher education semi structured researcher generated questionnaire transcripts academic results data analysed using spssv nvivov results findings revealed students showed modest improvements overall wellness scores correlation found student wellness academic success stronger students gained highest marks made two three lifestyle changes conclusion holistic salutogenic wellness education programme shows potential increase student wellness may translate student academic success
social stimuli often function reinforcers behavior children autism reinforcement social stimuli praise required maintenance generalization multitude social behaviors notably verbal behaviors maintained generalized conditioned reinforcement purpose study extend literature conditioning praise reinforcer identified primary reinforcers two nonverbal participants autism ages tickles potato chips preliminary reinforcer analysis demonstrated button pressing consistently frequent contingent primary reinforcer condition contingent praise programmed consequence conditions contingent pairing praise primary reinforcer administered min sessions responding praise alone evaluated pairing sessions day context reversal design praise probes pairing resulted increases button pressing praise condition relative programmed consequence condition addition consecutive pairing sessions resulted higher levels button pressing praise consecutive pairing sessions future research continue refining procedures conditioning attention reinforcer well examine closely role motivating operations process
present three field experiments probe influence choice architecture contributions total participants real charities first experiment framing one time donation opportunity opt opposed opt decision significantly increases donations environmental non profit second experiment automatic donation mechanism provided allows subjects self select opt framing combined incentive neutral social norm supporting activities cheap talk voting automatic donations sustain increased contributions ten month study period hiv aids related charity third experiment study extent mention hiv aids charity informational material impacts emotions donations potential donors case connection hiv aids elicit stigma find changes mood exposure charity informational material predict increased donations donors experience improved mood donating published elsevier inc
backgroundshunting glycolytic intermediates pentose phosphate pathway suggested protect hyperglycaemia induced microvascular damage hypothesized genetic variability gene encoding transketolase key pentose phosphate pathway enzyme contributes early nerve dysfunction recent onset diabetes methodsin cross sectional study assessed nine single nucleotide polymorphisms snps transketolase gene plasma methylglyoxal concentrations clinical quantitative measures peripheral nerve function type type diabetic patients diabetes duration year resultsthe total symptom score associated transketolase snps peroneal motor nerve conduction velocity mncv correlated cold thermal detection threshold tdt foot associated transketolase snps warm tdt hand correlated bonferroni correction correlations transketolase snp total symptom score warm tdt hand remained statistically significant among subgroups men type diabetes showed strongest associations associations observed nine tagged transketolase snps plasma methylglyoxal concentrations conclusionsthe observed associations genetic variation transketolase enzyme neuropathic symptoms reduced thermal sensation recent onset diabetes suggest role pathways metabolizing glycolytic intermediates early diabetic neuropathy copyright john wiley sons ltd
breakdown public distribution system north korea famine made way citizen led grassroots marketization means survival confluence several factors including skewed ratio males official jobs state sanctioned role women housewives mothers mandatory military service males predominance females light industry service sectors allowed women greater opportunity participate burgeoning market economy understudied aspect new phenomenon regional discrepancies north korea affect role women markets large regional socioeconomic differences exist north korea previous studies used haphazard samples refugees coming primarily northeastern province close china semi structured open ended oral history interviews five female refugees coming different regions north korea study paid special attention women witnessed changes several provinces including capital findings disparities certainly exist across regions urban rural gap pronounced study also confirmed despite double victims state marginalization social discrimination north korean women primary breadwinners nuclear family challenging traditional gender roles result nationwide market participation
many years ago beneficial effects using reinforcement improve property soil demonstrated last three decades use polymeric reinforcement geotextile increased geotechnical engineering among possible applications earth reinforcement techniques become useful economical techniques solve many problems geotechnical engineering practice improve bearing capacity settlement characteristics footing research presents effect geotextile inclusion bearing capacity two close strip footings located surface soft clay broad series finite element analysis performed two footings width using two dimensional plane strain model using computer code plaxis ver one type soft clay used analysis soil represented two yielding criteria including hardening soil model mohr coulomb model reinforcement represented elastic element interface reinforcements soft clay interface elements used wide range boundary conditions including unreinforced reinforced cases analyzed varying parameters number geotextile layers vertical spacing layers depth topmost layer geotextile tensile stiffness geotextile layers distance two footings numerical results bearing capacity ratio interference factor foundations estimated basis analysis performed research concluded best distance footings optimum depth topmost layer achieve maximum bearing capacity closely spaced strip footings bearing capacity also found increase increasing number reinforcement layers reinforcements placed within range effective depths addition analysis indicated increasing reinforcement stiffness beyond threshold value result increase bearing capacity
background whole genome amplification techniques enabled analysis unexplored genomic information sequencing single amplified genomes sags whole genome amplification single bacteria currently challenging contamination often occurs experimental processes thus increase confidence analyses sequenced sags bioinformatics approaches identify exclude non target sequences sags required since currently reported approaches utilize sequence information public databases limitations new strains targets interest developed software sag identify exclude non target sequences independent database results method template control sequences acquired wga used calculated probability sequence derived contaminants comparing mer compositions template control sequences based results tests using simulated sag datasets accuracy method predicting non target sequences higher currently reported techniques subsequently applied tool actual sag datasets evaluated accuracy predictions conclusions method works independently public sequence information distinguishing sags non target sequences method effective employed sag sequences unexplored strains anticipate contribute correct interpretation sags
determine maximum tolerated dose mtd tositumomab patients refractory recurrent hodgkin lymphoma preliminarily determine tositumomab activity positron emission tomography pet deoxy fluoro glucose performed weeks post therapy predicted week response separate dose finding studies performed patients without prior transplant single therapeutic total body radiation dose tbd tositumomab administered tbd escalated escalated based dose limiting hematologic toxicity dlt using modified continual reassessment method pet scans performed baseline weeks post therapy twelve patients nine classical three lymphocyte predominant completed two dosing levels post transplant cgy cgy transplant cgy cgy groups hematologic toxicities common transient twelve weeks tositumomab patients progressed two lphl achieved complete response pet weeks post therapy appeared predictive weeks response weeks tositumomab tositumomab well tolerated patients relapsed refractory complete responses lphl support therapeutic effect subtype early metabolic response assessments pet radioimmunotherapy appear predictive purely anatomic assessments
cancer cachexia severe disabling clinical condition frequently accompanies development many types cancer muscle wasting hallmark cancer cachexia associated serious clinical consequences physical impairment poor quality life reduced tolerance treatments shorter survival cancer cachexia may evolve different stages clinical relevance namely pre cachexia cachexia refractory cachexia given detrimental clinical consequences appears mandatory prevent delay progression cancer cachexia refractory stage implementing early recognition treatment nutritional metabolic alterations occurring cancer research molecular mechanisms underlying muscle wasting cancer cachexia expanded last years allowing identification several potential therapeutic targets development many promising drugs several agents already reached clinical evaluation becoming increasingly evident single therapy may completely successful treatment cancer related muscle wasting given multifactorial complex pathogenesis suggests early structured multimodal interventions including targeted nutritional supplementation physical exercise pharmacological interventions necessary prevent treat devastating consequences cancer comorbidity future research focus approach
treatment efficiency constructed wetlands cws highly dependent stability hydraulic flow patterns date general technologies used study hydraulic flow patterns cws mainly include tracer method model simulation velocity measurement either expensive empirical secondary pollution study new technology based isotopic composition variation cws applied detect hydraulic flow patterns two different cws results showed hydraulic flow patterns two studied wetlands could detected effectively using hydrogen oxygen isotopes furthermore locations stagnant areas sas preferential flow areas pfas also determined significant regional difference isotopic composition existed inside two wetland design suggestions proposed hydraulic analysis one influent cws supposed distributed uniformly another piece advice vegetation direction perpendicular water flow maintained types density elsevier rights reserved
background previous studies thoroughly investigated prevalence risk factors completed suicide marked contrast lack better understanding attempted suicide elderly aim study estimate prevalence attempted suicide elderly examine associated factors methods using multi stage cluster sampling approach cross sectional survey elderly house dwelling residents conducted shanghai china results two week prevalence attempted suicide elderly bivariate analysis caregivers depressive anxiety sad fear obsessive compulsive anger symptom lower scores barthel index activities daily living lawton instrumental activities daily living scale significantly associated increased risk attempted suicide elderly multivariate analysis sad fear symptoms significantly independently associated higher risk attempted suicide elderly conclusion two week prevalence attempted suicide elderly relatively high compared annualized lifetime prevalence reported china foreign settings elderly individuals certain mental symptoms targeted suicide prevention provided timely mental health support
literature data vehicle life cycle water consumption limited contradictory published estimates vehicle life cycle water withdrawal place future discussions sustainable mobility firmer technical basis report results cradle grave assessment water withdrawal water consumption gasoline internal combustion engine vehicle icev battery electric vehicle bev variants ford focus average life cycle water withdrawal consumption cubic meters respectively lifetime driving distance miles estimated focus icev using gasoline employing upper bound water use oil refinery operations corn ethanol production increases life cycle withdrawal consumption respectively average life cycle water withdrawal focus bev times icev reflecting large volume cooling water required electricity generation whereas water consumption comparable icev vehicle use significant phase life cycle fuel production accounting water withdrawal water consumption icev bev fuel electricity production accounts life cycle water withdrawal consumption results highlight importance renewable sustainable fuels increased vehicle energy efficiency providing sustainable mobility
study investigates perception honour related violence women female male university students three countries morocco cameroon italy considered honour cultures different terms various sociocultural factors family structure gender roles one hundred fourteen moroccan females males cameroonian females males italian females males students attending turin university currently living turin answered questionnaire evaluate act honour related violence father daughter results showed perception act influenced participants nationality italians evaluated incident serious crime moroccans latter cameroonians furthermore italians attributed less responsibility victim responsibility assailant moroccans cameroonians accordingly also proposed severe punishment assailant moroccans cameroonians results also showed interaction nationality gender cameroonian women attributed responsibility victim less assailant cameroonian men italian men attributed less responsibility assailant italian women results interpreted terms importance attributed family honour three countries differences social organisation gender roles
study provides national prevalence estimates military veterans severe pain compares veterans nonveterans similar age sex data used national health interview survey adults completed adult functioning disability supplement participants severe pain identified using validated pain severity coding system imbedded national health interview survey adult functioning disability supplement estimated military veterans reported pain previous months classified severe pain compared veterans fewer nonveterans reported pain severe pain whereas veterans aged years significantly higher prevalence rates severe pain similar aged nonveterans veterans age years older less likely report severe pain nonveterans male veterans likely report severe pain male nonveterans however statistically significant difference seen female groups prevalence severe pain significantly higher veterans back pain jaw pain severe headaches migraine neck pain nonveterans conditions respectively although veterans likely nonveterans joint pain difference seen prevalence severe pain associated condition perspective prevalence severe pain defined occurs days every day bothers individual lot strikingly common veterans members general population particularly veterans served recent conflicts additional assistance may necessary help veterans cope pain published elsevier inc behalf american pain society
rapid development economics country large number high level specialized talents needed universities expand enrollment scope recruit year undergraduates professional degree postgraduates study country order improve training quality control engineering full time professional degree postgraduate series reforms carried northeast petroleum university experience practice represented
utilizing complex dynamics chaotic maps systems encryption studied comprehensively pas two half decades fridrich chaotic image encryption scheme designed iterating chaotic position permutation value substitution rounds received intensive attention field chaos based cryptography solak proposed chosen ciphertext attack fridrich scheme utilizing influence network cipher pixels corresponding plain pixels based creative work paper scrutinized properties fridrich scheme concise mathematical language minor defects real performance solak attack method given work provides base optimizing attack fridrich scheme variants
cryptococcosis fungal infection relatively rare absence impaired immunity lung brain may involved cryptococcal dissemination rare absence impaired immunity documentation alone adrenal involvement without central nervous system involvement rare present case immunocompetent patient presented bilateral adrenal cryptococcosis adrenal insufficiency without central nervous system involvement fdg pet correctly identified residual disease
background recent years number government sponsored initiatives implemented germany focused early preventive intervention child protection response need interdisciplinary training area internet based learning program early preventive intervention child protection developed professionals child welfare health care systems working families infants toddlers program currently undergoing evaluation effectiveness user satisfaction methods pre post design users requested complete questionnaires assess three measures expertise theoretical knowledge relevant fields ability correctly identify subtle signals infant communication ability assess maternal sensitivity article presents contents program pre training results participants descriptive analyses well pearson correlations bonferroni corrections error conducted using statistical program spss results findings show wide range professionals making use program existing theoretical knowledge early preventive intervention well ability identify subtle signals infant communication relatively good however ability assess maternal sensitivity considered crucial indicator risk child abuse low conclusions outcome pre training results indicates professionals working area child protection need develop capability recognizing maternal sensitivity order ensure early detection families risk thus need support finally number years professional experience correlate scores three measures emphasizes importance providing interdisciplinary training area working child family services regardless background
rise location based services enabled many opportunities content service providers optimize content delivery user wireless devices based location since sharing precise location remains major privacy concern among users certain location based services rely contextual location residence work etc opposed acquiring user exact physical location paper present pacl privacy aware contextual localizer model learn user contextual location passively monitoring user network traffic pacl discern set vital attributes statistical application based user network traffic predict user contextual location high accuracy design evaluate pacl using real world network traces users total data results show pacl built using bayesian network machine learning algorithm predict user contextual location accuracy around elsevier rights reserved
new model interface problems capillary effects compressible fluids presented together specific numerical method treat capillary flows pressure waves propagation new multiphase model agreement physical principles conservation respects second law thermodynamics new numerical method also proposed global system equations split several submodels submodel hyperbolic weakly hyperbolic solved adequate numerical method method tested validated thanks comparisons analytical solutions laplace law experimental results droplet breakup induced shock wave elsevier inc rights reserved
modal analysis large span suspension bridge different construction stages carried aerodynamic instability analysis based finite element model triple tower twin span ttts suspension bridge completed stage models tower cable deck system corresponding deck units erection stage established respectively backward dismantling method dynamic characteristics tower cable deck systems analyzed study modal properties ttts suspension bridge various deck erection stages results demonstrate natural frequencies erection stage closely distributed low order range beginning deck units erection stage tower cable dominated modes primary modes deck dominated modes come next due strong interactions deck unites cables plane plane vibrations cables would excite swing lifting torsional modes deck units plane plane modes including phase phase modes two main cables span symmetry anti symmetry modes neighboring span cables well corresponding combinations classified groups deck unites erected main girder built gradually thus frequencies deck dominated mode would arise different frequency variations result modal crossover phenomena reflect instability dynamic characteristics long deck erection period last aerodynamic stability suspension bridge checked early erection stage wind ropes application aerodynamic stability enhancement investigated study dynamic characteristics provides reference wind resistance analysis ttts suspension bridge deck units erection stage
paper consider variable coefficient calogero degasperis equation variable coefficient potential kadomstev petviashvili equation generalized dimensional variable coefficient kadomtsev petviashvili equation time dependent coefficients shock wave solutions considered models obtained using ansatz method form tanhp function physical parameters soliton solutions obtained functions dependent coefficients copyright john wiley sons ltd
purpose identify main concerns broad range hospital staff implementation new computerized provider order entry cpoe system medication management methods study conducted large australian teaching hospital using semi structured inter views focus groups six focus groups involving total participants broad section health professionals including doctors nurses managers pharmacists senior health executives systematic concurrent analysis data undertaken team researchers results identified recurrent themes related nine areas shared concern including work practices software hardware relationships communication education training inexperienced staff skilling higher level analysis identified four interrelated constructs highlight people concerned help work cope impair existing interaction limitations research provides snapshot overview perceptions range hospital personnel lead cpoe implementation generalizability limited size sample contextual circumstances hospital studied discussion work contributes valuable evidence often neglected dimension evaluation computer systems hospitals namely pre implementation concerns staff pre conceptions significant effect technology implemented utilised acknowledging addressing people concerns contribute establishment durable channels negotiation communication research informed findings study help advance process elsevier ireland ltd rights reserved
experiments assisted living confirm systems provide context aware services enable occupants remain active independent also demonstrate abnormal sensor events hamper correct identification critical potentially life threatening situations existing learning estimation time based approaches inaccurate inflexible applied multiple people sharing living space propose technique integrates semantics sensor readings statistical outlier detection evaluate technique four real world datasets include multiple individuals show consistent rates anomaly detection across different environments
operational amplifier amp really significant widely used building block analog mixed signal circuit design since performance amp integrated circuit affects overall performance system therefore power consumption amp needs reduced designs low power circuits require reduction internal power supply voltage minimum interconnection parasitic elements considering requirements low power low voltage high efficient circuit ultra low power low voltage two stage cmos amp high open loop gain gain high unity gain bandwidth ugb proposed achieve accuracy fast settling requirements giving power supply work high open loop gain fast settling time attained cascode technique unity gain bandwidth enhanced help gain stage miller capacitor feedback path proposed amp provides open loop gain unity gain bandwidth mhz power consumption simulations performed using cadence technology
background inappropriate use systemic antifungal agents result unnecessary exposure adverse events increased microbial resistance increased costs aim study analysed use systemic antifungal agents adherence treatment guidelines fungal infections setting brazilian tertiary hospital methods cross sectional study investigated patients treated systemic antifungals antifungal drugs classified according fourth level anatomical therapeutic chemical classification system appropriateness treatments analysed respect indication dose potential drug drug interactions descriptive univariate statistical analyses performed main outcome measure frequency adherence treatment guidelines fungal infections results number established treatments pre emptive targeted empirical prophylactic treatments overall adherence treatment guidelines proportion appropriate treatment considering indication dosage drug drug interactions respectively commonly prescribed systemic antifungal agents fluconazole voriconazole amphotericin deoxycholate cases conclusion study showed low proportion appropriate antifungal drug use dosage drug drug interactions criteria determining factors high percentage non adherence treatment guidelines hospital profile antifungal agents used showed predominance fluconazole well use new antifungal drugs
decade iranian population growth rate remained constant around percent address issue iranian government terminated national family planning program removed information birth control methods school education media government websites moreover iranian ministry health medical education mohme implemented program entitled reproductive health aim increasing fertility rate least percent accordingly women reproductive age fewer three children found encouraged deliver least three children mohme also restricted providing permanent sterilization services community new regulations banned advertisement family planning health clinics policies potentially significant negative consequences public health iran therefore provide set recommendations health policy public health points view includes improving maternal child health prevention non communicable diseases traffic injury prevention strengthening elderly health care
objective despite extensive use treating cognitive deficits schizophrenia computer assisted cognitive remediation cacr currently lacks standardized protocol duration important feature defined may contribute heterogeneous outcome study compares treatment durations versus months analyze effects cognition daily functioning method fifty seven outpatients schizophrenia received months cacr received months cacr patients assessed baseline months brief assessment cognition schizophrenia quality life scale qls results repeated measures anova showed significant improvements cognitive domains months significant effect treatment duration observed executive functions significantly higher scores among patients treated months significant improvements qls also observed months groups significant time treatment interaction qls total score conclusions results confirm efficacy months cacr terms cognitive functional improvements suggesting extended intervention may lead benefits executive functions daily functioning
anaplastic lymphoma kinase alk inhibitor alectinib effective treatment alk positive non small cell lung cancer bioequivalence study evaluated vivo performance test formulations reduced wetting agent sodium lauryl sulfate sls content randomized period sequence crossover study compared alectinib sls hard capsule formulations reference sls clinical formulation healthy subjects fasted conditions following high fat meal geometric mean ratios confidence intervals cis max auc last auc infinity alectinib major active metabolite alectinib plus determined test formulations versus reference formulation bioequivalence concluded cis within boundaries sls formulation demonstrated bioequivalence reference sls formulation max auc last auc infinity alectinib alectinib plus fasted fed conditions reductions sls content sls meet bioequivalence criteria cross group comparisons showed approximately fold positive food effect reducing sls resulted formulation bioequivalent current sls formulation used alectinib pivotal trials
whole grain consumption associated reduced risk chronic disease one fifth adults children consume whole grains adolescents low consumption rates factors affecting whole grain intake among adolescents well understood study examined socioeconomic environmental lifestyle psychological factors likely influence consumption explored whether outcomes aligned behavioural predictors proposed reasoned action approach five focus groups explored young people attitudes towards knowledge consumption wholegrain foods well barriers facilitators consumption participants male female adolescents aged years mixed socioeconomic backgrounds ethnicities recruited schools city leeds focus groups analysed using thematic analysis participants tried wholegrain food products cereal products popular many recognised whole grain health benefits related digestive health related heart disease cancers several barriers eating whole grains identified including difficulties identifying wholegrain products health benefits taste visual appeal poor availability outside home suggested facilitators consumption advertisements educational campaigns followed improved sensory appeal increased availability choice tailoring products young people constructs theory reasoned action identifiable data suggesting factors influencing whole grain intake adolescents well captured model study outcomes may inform research health promotion increase whole grain intake age group elsevier ltd rights reserved
aim experimental study improve energy absorption capacity tubular metallic structures plastic buckling increasing strength properties materials based novel idea change plastic strength materials could predictable loading pathcomplexity concept original experimental device represents patent issue developed uniaxial loading biaxial combined compression torsion loading path generated means device tests carried investigate biaxial plastic buckling behavior several tubular structures made copper aluminum mild steel effects loading path complexity geometrical parameters structures loading rates notably tangential one plastic flow mechanism mean collapse load energy absorbed carefully analyzed results related copper aluminum metals show plastic strength properties tubes crushed biaxially change torsional component rate emphasizes energy absorption improves increasing applied loading complexity however energy absorbed data mild steel tubular structures demonstrate sensitivity quasi static loading path complexity
testosterone deficiency hypogonadism common conditions men chronic kidney disease ckd disturbed hypothalamic pituitary gonadal axis due ckd thought contribute androgen deficiency data experimental studies support hypothesis exogenous administration testosterone may induce activation renin angiotensin system ras production endothelin regulation anti proinflammatory cytokines involved pathogenesis hypertension kidney damage hand low testosterone levels male patients ckd paradoxically associated higher risk morbidity mortality possibly explained anemia osteoporosis cardiovascular disease article present overview clinical experimental studies impact testosterone progression prognosis male patients ckd even today remains controversial issue
examined formal organizational diversity policies affect minorities leadership relevant self perceptions goals two experiments organizational mission statements manipulated reflect policies acknowledging valuing subgroup differences multiculturalism emphasizing subgroup differences valuing interindividual differences value individual differences emphasizing differences favor overarching group membership value homogeneity study showed compared value homogeneity policies multiculturalism value individual differences policies increase perceptions open diversity climate turn enhance leadership self efficacy situational minority employees focusing racial ethnic minority majority employees study replicated extended findings revealing similar results anticipated leadership self efficacy positive outcome expectations willingness apply higher level leadership positions
background although acitretin widely used treatment psoriasis additional safer effective approaches including traditional chinese medicine needed objectives investigate efficacy safety total glucosides paeony tgp combined acitretin treatment moderate severe plaque psoriasis materials methods randomised double blind placebo controlled multi centre clinical study conducted total patients moderate severe plaque psoriasis randomly assigned treatment tgp plus acitretin group placebo plus acitretin group weeks results weeks therapy percentage patients achieving reduction psoriasis area severity index group group rate serum alanine aminotransferase elevation group group conclusion tgp conducive enhancing anti psoriatic efficacy reducing liver damage due acitretin tgp combined acitretin safe effective treatment approach moderate severe plaque psoriasis
drill stem vibration may cause drilling inefficiencies often leads non productive time drill stem vibration analysis performed prevent identify rpm values may cause damaging standing waves drill stem however different models assumptions give different vibration results one simplification commonly done excluding drilling fluids paper investigates effect including drilling hydraulics dynamic pressure drill stem vibrations model assumes drill stem acting euler bernoulli beam discretized using finite element formulation two fluid rheological models herschel bulkley power law used determine uncoupled dynamic pressure drop across drill stem results show including dynamic pressure drill stem vibration model causes critical rotational speeds change much rpm expected axial torsional vibrations affected lateral vibration changes significantly ratio wellbore diameter drill stem outside diameter narrow total drill bit flow area operating high flow rates therefore creating rpm road maps avoid vibrations drilling contribution dynamic pressure included elsevier rights reserved
introduction mitochondrial neurogastrointestinal encephalopathy mngie disease extremely underrated syndrome beginning around age eighteen years severity diagnosis considered patient presents atypical anorexia nervosa mngie disease inherited autosomal recessive manner related mutations tymp gene chq qter encoding thymidine phosphorylase mngie often misdiagnosed associated time diagnostic years first symptoms thus critical review aims help clinicians better identify symptoms paraclinical markers mngie differential diagnosis atypical anorexia nervosa methods literature search performed using pubmed google scholar databases results clinical diagnosis mngie disease based association severe loss weight additional symptoms severe gastrointestinal dysmotility nausea vomiting intestinal pseudo obstruction ptosis external ophtalmoplegia peripheral sensorimotor neuropathy mngie disease clinically suspected paraclinical testing help validate mngie diagnostic arterial blood test reveals lactic acidemia increased serum concentration lactate without modifications brain mri indicates leukoencephalopathy usually asymptomatic direct evidence mngie disease based specific testing thymidine phopshorylase enzyme activity leukocytes less control increase plasmatic thymidine mol increase plamatic deoxyuridine mol evidence mutations tymp gene molecular genetic testing conclusion mngie disease severe trouble multisystemic complications thymidine phopshorylase enzyme activity leukocytes measured soon possible patient presents atypical anorexia nervosa encephale paris
objective investigate association hypogonadal symptoms serum total testosterone levels young men aged years attempt determine whether exists clear cut discriminatory threshold hypogonadal symptoms become prevalent patients methods retrospectively reviewed charts men presented outpatient men health clinic chief complaint low testosterone sexual psychological physical symptoms evaluated using androgen deficiency aging male adam questionnaire serum levels collected day men completed adam questionnaires subsequently performed univariate test chi square multivariate analyses ordinal logistic regression evaluate factors predicted low level results probability hypogonadal symptoms increased serum level cluster symptoms two psychological decreased energy sadness three physical decreased strength endurance decreased ability play sports deterioration work performance strongly associated serum levels multivariable analysis lack energy predicted level conclusions hypogonadal symptoms men aged years associated level hypogonadal symptoms evaluated adam questionnaire lack energy appears important symptom predicts level
due increased life expectancy older population growing probability elderly person testify eyewitness victim robbery similar crime however little known aging effects testimony accuracy circumstances older adults would prone memory errors younger adults study older younger adults memory actions robbery examined recognition test although differences found hits older adults higher proportion false alarms showed less accurate recognition younger adults addition older adults less able attribute actions occurred robbery correct sources thus source memory deficits may contribute explain older adults less accurate recognition finding taken account real life eyewitness situations elderly person involved
session initiation protocol sip proved integral part parcel multimedia based application based telephony service requires signaling sip supports http digest based authentication responsible creating maintaining terminating sessions guarantee secure sip based communication number authentication schemes proposed typically based smart card due temper resistance property recently zhang presented authenticated key agreement scheme sip based elliptic curve cryptography however peer peer netw appl finds scheme insecure user impersonation attack furthermore presented improved scheme claimed secure known attacks recently farash peer peer netw appl points scheme vulnerable server impersonation attack farash also proposed improvement scheme however analysis paper shows scheme insecure server impersonation attack scheme farash improvement protect user privacy vulnerable replay denial services attacks order cope limitations proposed privacy preserving improved authentication scheme based ecc proposed scheme provides mutual authentication well resists known attacks mentioned farash
model mathematical description inulin biosynthesis particular focus dynamics sucrose kestose concentration developed model takes account specific action two involved enzymes sst fft principle inulin biosynthesis thus described thermodynamically stabilizing process leading stable nodal sink time initial phases reaction oscillation sucrose kestose concentration observed dampening rapidly products stable steady state condition applying boundary conditions higher number average degree polymerization lead higher frequency amplitude oscillation
many individuals clinical samples borderline personality disorder bpd experience high levels functional impairment however little known levels functional impairment experienced individuals bpd general community address issue compared overall domain specific educational occupational social recreational functioning sample community based individuals bpd community based individuals without bpd clinically ascertained individuals bpd bpd diagnoses functional outcomes based well accepted semi structured interviews community based individuals bpd significantly less likely experience good overall functioning steady consistent employment good relationship compared community based individuals without bpd bpd non bpd risk difference even compared directly non bpd siblings risk difference community based individuals bpd versus without bpd differ significantly domain specific outcomes former group experienced poorer educational occupational performance lower quality relationships parents partners friends however community based individuals bpd significantly likely experience good overall functioning clinically based individuals bpd risk difference latter group likely experience reduced employment status poor quality relationships partners social isolation conclusion community based individuals bpd experienced marked functional impairment especially social domain less likely experience extreme occupational social impairments seen among patients bpd elsevier ltd rights reserved
aim aim study explore value adding narrative perspective listening two drug users comorbid antisocial personality disorder aspd experienced participation intervention treatment targeting antisocial behaviour methods two cases chosen representing low high level change participation programme intervention targeting aspd within outpatient drug treatment interpretative phenomenological analysis used capture quality experiences narrative sense making strategies findings two cases converged core preconceptions individuals aspd contradicted others experiences narratives differed ways perceived life challenges feelings agency control concerning ability engage change processes without losing core self conclusions responding adequately user experiences requires paying attention individual narratives sense making strategies certain aspects aspd may exclusive indications pathological processes serve important function engaging treatment change taking approach potential facilitate constructive dialogue aspects behaviour makes sense change
algorithm automatic digitization pluviograph strip charts presented rainfall signal incrementally extracted scanned image strip chart combining moving average method curve edge following method mechanical properties float based rain gauge used constraints algorithm design algorithm tested strip chart images comparison data derived algorithm data slovenian environment agency shows algorithm produces accurate rainfall time series except charts contain ink smudges thus algorithm well suited main component interactive system would enable visual inspection detected rainfall curve possible adjustment
despite widely published speculation regarding potential potency advantage short wavelength blue appearing light seasonal affective disorder sad treatment systematic studies comparing short wavelength broad wavelength white light actual clinical conditions suggest equivalent effectiveness multicenter parallel group design trial undertaken compare effects light therapy sad using blue similar versus blue free led lights fifty six medication free subjects aged years met dsm criteria recurrent major depression winter type seasonal pattern enrolled blinded study five participating centers january march thirty five subjects met criteria randomization min either blue similar blue free daily morning light therapy twenty nine subjects completed study three subjects withdrew due treatment related adverse events including migraines three withdrew non study related reasons primary effectiveness variable depression score sigh ads six weeks daily light treatment secondary effectiveness variables included quality life qol suicidality ratings using intent treat analysis mean depression scores different baseline blue group versus blue versus blue free respectively initial score used covariate baseline scores significantly different treatment groups among completed study significant differences depression scores observed weeks mean scores weeks versus blue versus blue free respectively addition proportion subjects met remission criteria defined depression score significantly different two groups among subjects completed study subjects experienced remission end trial coincided beginning spring qol suicidality ratings also significantly improved pre post treatment significant difference treatments subject experienced worsening non improved symptoms week trial main finding study subjects treated blue light improve subjects treated blue free light showed substantial improvement multiple measures failure find differences may resulted methodological constraints including small sample size recruitment began mid winter unusually mild season trial terminated earlier planned study sponsor due failure detect difference however confirmed larger randomized sample results suggest blue wavelengths necessary successful sad treatment
previous study examined differences treatments outcomes acute myocardial infarction ami patients without rheumatoid arthritis setting coronary reperfusion therapy readily available study aimed examine whether coexisting affected likelihood receiving coronary reperfusion therapy hospital mortality among ami patients japanese nationwide setting coronary reperfusion therapy readily available using diagnosis procedure combination database retrospectively identified patients admitted ami created matched pair cohort patients without based age sex hospital admission year maximum ratio performed multivariable logistic regression analyses associations likelihood coronary reperfusion therapy day hospital mortality significant differences group non group proportions patients receiving coronary reperfusion therapy day admission hospitalization day hospital mortality multivariable logistic regression analyses showed significantly associated either likelihood receiving coronary reperfusion therapy hospitalization odds ratio confidence interval day hospital mortality odds ratio confidence interval coexisting affect likelihood receiving coronary reperfusion therapy hospital mortality among ami patients setting reperfusion therapy readily available
introduction previous studies demonstrated students attention deficit hyperactivity disorder adhd struggle particularly grasping implicit inferential level narratives crucial story comprehension however studies used offline tasks story presentation used indirect measurements identifying main ideas yielded inconclusive results using think aloud techniques moreover studies conducted preschool elementary school children adhd using listening televised story comprehension study interested examining spontaneous immediate activation suppression forward predictive inferences backward explanatory inferences inference evoking textual information occur online reading comprehension adolescents adhd method participants without adhd read short narrative texts included predictive sentence bridging sentence referred back predictive sentence via actualization predicted event two intervening sentences positioned predictive bridging sentences introduced temporary transition main predictive episode activation suppression inferential textual information assessed using naming times word probes implied preceding text explicitly mentioned neither following control texts cases true false inferential textual question followed probe results naming facilitations observed control adhd group responding inference probes followed predictive bridging sentences text probes followed predictive sentences participants adhd accurate albeit slower controls answering true false questions conclusions adolescents adhd difficulties generating predictive explanatory inferences retaining relevant textual information working memory reading although answer questions reading texts relatively short findings discussed regard development comprehension strategies individuals adhd
quality composition biomass used portugal thermal power plants highly variable biomass consists mainly residual forest biomass derived forestry operations wood waste industrial processes particular paper pulp industry quality composition influenced presence moisture inert fragments latter incorporated collection consequence adherence biomass prior collection variability presents difficulties thermal power plants besides additional operational cost presence large amounts water inerts biomass used fuel result problems related instability combustion accumulation ash rock removed discarded objective paper review main parameters influence quality biomass analysing current state art power generation biomass sector portugal new contribution earlier studies
deindividuation may described situation individuals act groups see individuals thereby facilitating antinormative behavior present article analyzes construct deindividuation theory conceptualization bon recent theoretical model social identity model deindividuation effects aim study compare theories deindividuation highlight advances identify theoretical questions remain suggest future directions study issue recent research conducted deindividuation may promote prosocial behavior prevent social disturbance prevent development prejudice among children furthermore may provide feasible way comprehend intervene contemporary social issues recent scientific techniques neuroimaging predictive mathematical models may improve comprehension construct terms definition prospective effects
water use control methods water resources planning high priority irrigated agriculture right way save water increase water use efficiency better management present work validates procedures methodologies using remote sensing determine water availability soil moment giving opportunity application water depth strictly necessary optimise crop growth optimum irrigation timing irrigation amount analysis applied irrigation district divor evora using experimental plots areas irrigated centre pivot systems cultivated maize data determined images cultivated surface obtained satellite integrated atmosphere crop parameters calculate biophysical indicators indices water stress vegetation normalized difference vegetation index ndvi kcb therefore evapotranspiration etc estimated used calculate crop water requirement together opportunity amount irrigation water allocate although remote sensing data available satellite imagery presented practical constraints study could contribute validation new methodology used irrigation management large irrigated area easier lower costs traditional fao recommended crop coefficients method remote sensing based methodology also contribute significant saves irrigation water elsevier rights reserved
background wolves shown better independent problem solving tasks dogs however unclear whether cognitive motivational factors underlie differences number species problem solving linked persistence exploration neophobia suggesting aspects may underlie dog wolf differences problem solving indeed adult wolves shown likely approach novel object persistent investigation also slower making contact fearful dogs methods current study investigated potential differences equally raised dogs wolves explorative neophobic behaviors novel environment novel objects weeks age results results showed wolves persistent exploring environment objects dogs case ages differences frequency fear related behaviors time spent proximity humans stress related behaviors similarly expressed weeks although wolves showed higher frequency behaviors weeks discussion overall results puppies confirm adult animals wolves appear explorative dogs motivational differences need taken account comparing dogs wolves cognitive tasks
paper system proposed combine small finger movements large scale body movements captured motion capture system strength proposed work previous research real time natural interactions virtual hands environment able conform physics virtual hands feel like virtual extensions one hands provides higher degree immersion interactivity compared traditional virtual reality systems
usage geotextile based artificial soil materials recently increase coastal protection applications materials become important temporary solutions lack supplying natural materials rock quick solutions cases one important applications geotextile application coastal engineering one several layer geotubes overlap replacements height wave run coast line near protecting coastal area stability type structures generally tested numerically wave loads determined geotubes presented paper numerical model generated extreme wave loads geotube compared bearing capacity geosynthetic black sea coast turkey protecting filled zone
approximately one half oncological patients worldwide use complementary alternative integrative methods state evidence therapies used inhomogeneous integrative oncology understood combination conventionally approved medicine conventional mainstream medicine scientifically tested complementary medicine mind body medicine article gives brief survey state evidence well fields application mind body medicine integrative oncology efficacy relaxation techniques reduction anxiety nausea enhancement quality life well documented level evidence mindfulness based stress reduction mbsr shows positive effects primary therapy anxiety stress reduced quality sleep health related quality life hrqol enhanced also good evidence positive effects yoga hrqol breast cancer patients qigong tai chi beneficial reduction fatigue well improvement sleep quality vitality hrqol preoperative hypnosis reduce doses anesthetic drugs alleviate pain nausea vomiting fatigue emotional strain many methods mind body medicine good state evidence particularly recommendable meditation mbsr enhancement hrqol reduction depression better general stress management relaxation training reduction depressive symptoms yoga combat depression mood disturbances fatigue well hypnosis combat fatigue
direct acting oral anticoagulants doacs introduced alternatives warfarin stroke prevention non valvular atrial fibrillation treatment venous thromboembolism many patients undergoing major gastrointestinal resections bypass receive anticoagulants various indications including treatment thrombotic complication surgery prevention visceral vessels events recurrence doacs wide therapeutic range allows fixed dosing determined based studies conducted healthy subjects normal absorptive capacity patients significantly altered gastrointestinal tracts included phase iii studies assessed doac efficacy safety aim article review clinical data doacs use patients major surgical resection bypass medline embase searched identify studies case reports doac use population prescribing information four approved doacs also reviewed types available literature identified case series isolated case reports patients underwent major distal intestinal resection successfully anticoagulated rivaroxaban dabigatran effective uncertainty efficacy rivaroxaban dabigatran patients requiring anticoagulation roux gastric bypass avoidance rivaroxaban therapy patients undergoing gastrectomy advised data lacking regarding anticoagulation using apixaban edoxaban patients major gastrointestinal resection bypass lacking clinicians aware limitations using doacs group patients
wetlands ability accumulate large amounts carbon therefore wetland restoration proposed means sequestering atmospheric carbon dioxide help mitigate climate change growing interest using services wetlands help reduce habitat loss finance restoration projects however including wetlands markets worldwide requires better mechanistic understanding methane exchange instruments models accurately inexpensively monitor predict fluxes across global wetlands remote sensing technology including near surface satellite instruments approaches effective tool modeling fluxes including gross primary productivity gpp site global scale study evaluate potential using digital cameras simple cost effective means estimating gpp restored wetlands assess suitability using landsat data model gpp environments regional upscaling research focused restored temperate freshwater marshes due high sequestration potential observed ecosystems daily gpp strongly correlated site greenness derived camera imagery gcc cam based show potential using gcccam eddy covariance data adapt parameterize light use efficiency lue model predict daily gpp lue model combining gcccam meteorological data able explain variation daily gpp restored marshes predict annual gpp budgets within observed budgets however model performance decreased increasing site complexity highlighting need explicitly consider spatial heterogeneity lue models also tested similar model using landsat derived indices found although model performance high homogeneous wetland dominated emergent vegetation data model agreement decreased site comprised mixture open water vegetation reflecting limitations landsat data nonetheless show digital camera land sat imagery used model photosynthesis restored wetlands providing low cost methods monitoring capture used market funded wetland conservation restoration elsevier rights reserved
differences cognitive emotional ratings involving aggressive content texts men women different level psychoticism analyzed texts scenes violence previously subjected expert procedure identification content emotivity estimated probationers means cognitive questionnaire enables scale emotional informational activational components texts content according obtained data maximal significant differences texts ratings revealed groups men women high level psychoticism thus confirming existence sex differences mechanisms determine psychoticism results discussed context modem researches psychoticism
background cognitive interventions either restorative compensatory developed mild alzheimer disease tested widely cognitive measures less known effects interventions generalizable daily functioning present study looked affective state perceived functionality quality life indicators three different cognitive rehabilitation programs methods fifty one patients mild stage disease selected study randomly assigned one three cognitive training groups memo paper pencil memory training program sensecam wearable camera used passive external memory aid written diary personal journal used control condition patients attended sessions twice week hour length three outcome indicators examined standardized instruments applied intervention one week six months follow results treatment sensecam memo groups significantly reduced depressive symptoms compared diary control condition found measures perceived functional capacity intervention effects found quality life measures immediate effects interventions maintained follow conclusions results suggest two types memory rehabilitation improve depressive symptomology instrumental activities daily living suggesting interventions stimulate cognition also well least short term
engineering education engineering practice relationship premises train reserve personnel meeting requirements engineering engineering education must return engineering therefore particularly important construct engineering education center well creates engineering practice condition real engineering environment students discussions done classification properties functions construction management significance improving quality engineering education
paper describes structure manufacturing engineering data integrated process manufacturing resources planning recommendations requirements data structures integration effective computerization manufacturing engineering presented examples data structure data base original integrated computer aided manufacturing engineering system provided
research social psychology potential address real world issues involving racial stereotyping prejudice discrimination literature confrontation suggests addressing racism seen persuasive act allow effective interpersonal interactions article explore persuasive communication literature context classroom education pervasiveness racial bias examine challenges instructors might face students finally suggest strategies might allow effective classroom experience
neural underpinnings emotion dysregulation borderline personality disorder bpd characterized limbic hyperactivity disturbed prefrontal activity unknown whether neural correlates emotion regulation change psychotherapy goal improve emotion dysregulation bpd dialectical behavioral therapy dbt investigated distraction main emotion regulation strategy dbt female patients bpd thirty one bpd patients instructed either passively view memorize letters confronted negative neutral pictures distraction task functional magnetic resonance imaging paradigm applied week residential dbt based treatment program compared dbt group bpd control patients continued usual non dbt based treatment treatment healthy participants behaviorally bpd groups healthy participants differ significantly respect alterations time neural level bpd patients received dbt based treatment showed activity decrease right inferior parietal lobe supramarginal gyrus distraction negative rather neutral stimuli compared control groups decrease correlated improvement self reported borderline symptom severity dbt responders exhibited decreased right perigenual anterior cingulate activity viewing negative rather neutral pictures conclusion findings reveal changes neural activity associated distraction emotion processing dbt patients bpd changes point lower emotional susceptibility distraction bpd symptom improvement
basketball game involves beyond physical preparation individual technical tactical knowledge essential good development game proactive attitude towards goal action team spirit consists interaction players based mutual knowledge acceptance understanding cooperation reaching common goal athletes ability communicate create relationships analysed connection individual ability shift attention sociometric preferential statuses consequently team cohesion level sociometric analysis achieved periodically according team structure composition evolution order ensure optimal integration athletes team increase cohesion eventually performance sociometric analysis correlated nonverbal communication ability knowing preferential status indices psi purpose research subjects members representative women basketball team juniors nonverbal communication ability positively correlates preferential status index team player research methods bibliographic study pons profile nonverbal sensitivity test moreno psycho sociometric analysis statistical mathematical method graphical representation average score obtained calculating psi negative value close zero namely regarding minimal maximal values noted balanced distribution scores compared central tendency value pearson correlation coefficient pons psi variables indicates close positive correlation variables published future academy www futureacademy org
paper describes requirements design principles electric motor helicopter tail rotor application application demands high specific power specific torque little possibility adopt liquid cooling solution tail rotor shall also comply severe safety requirements directly affect motor design volume weight constraints make design electrical machine challenging different solutions investigated propose effective alternative fenestron mechanical actuation system paper two different permanent magnet motors external rotor illustrated compared
classification numeric estimation two common types data mining goal classification predict discrete type output values whereas estimation aimed finding continuous type output values predictive data mining generally achieved using one specific statistical machine learning technique construct prediction model related studies shown prediction performance kind single flat model improved utilization hierarchical structures hierarchical estimation approaches usually combination multiple estimation models proposed solving specific domain problems however literature generic hierarchical approach estimation hybrid based solution combines classification estimation techniques hierarchically therefore introduce generic hierarchical architecture namely hierarchical classification regression hcr suitable various estimation problems simply speaking first level hcr involves pre processing given training set classifying classes leading subsets three approaches used perform task study hard classification fuzzy means fcm genetic algorithms training data containing associated class label used train support vector machine svm classifier classification next second level hcr regression estimation models trained based corresponding subsets final prediction experiments based different uci datasets show hierarchical prediction models developed hcr architecture significantly outperform three well known single fiat prediction models linear regression multilayer perceptron mlp neural networks support vector regression svr terms mean absolute percentage error mape root mean squared error rmse rates addition found using based data pre processing approach classify training set subsets best threshold class svm mlp outperforms three baseline hierarchical regression models
performance reluctance synchronous machine rsm strongly depends well designed geometry stator rotor within intention high torque high power factor difference ratio direct quadrature inductance must set maximum paper easy semi analytic design method used determine inductances reluctance machine standard induction machine stator multiple flux barrier rotor varying rotor stator dimensions bore diameter slot geometry effect difference ratio inductances therefore output performance parameters studied analysis simplified analytical model magnetic circuit model reluctance synchronous machine created solved iteratively rsm leakage inductances determined using analytical equations used induction motors optimum design various objective functions like maximum torque maximum torque per kva maximum torque per volume found means analytic model result important conclusions achieved regarding stator rotor design respectively
background bonexpert newly developed medical device based digital ray radiogrammetry measure human cortical bone thickness aim study quantify cortical bone loss metacarpals patients psoriatic arthritis psa compare findings radiological scoring methods methods study includes patients verified psa method used measure metacarpal index mci metacarpal bones additionally score mci score mci calculated radiographic severity determined psoriatic arthritis ratingen score proliferation score destruction score published wassenberg psoriatic arthritis modified van der heijde sharp score joint space narrowing score erosion score results total psa study cohort scoremci significantly reduced mci negatively correlated proliferation score destruction score psoriatic arthritis ratingen score lower coefficients correlations observed psoriatic arthritis modified van der heijde sharp score context severity dependent psa related periarticular demineralisation measured mci quantified strongest reduction observed mci destruction score conclusions mci score showed periarticular demineralisation severity dependent bone loss patients psa measurements technique able sensitively differentiate different stages disease manifestation affecting bone integrity thereby seem achieve potential surrogate marker radiographic progression psa
ultra precision coordinate measuring machine cmm trinano developed design workpiece mounted stage driven three parallel drives mutually orthogonal linear drives support stage using vacuum preloaded vpl air bearings whereby drive determines position stage along one translation direction exactly constrained design results highly repeatable machine behavior furthermore machine complies abbe principle full measurement range application parallel drives allows excellent dynamic behavior design allows measurement uncertainty nanometers measurement range cubic centimeters verification measurements using gannen tactile probing system spherical artifact show standard deviation single point repeatability around direction
study adds body research examining links two components cognitive self regulation inhibitory control verbal working memory social functioning social integration social problem solving prosocial skills focuses children sex moderator association cognitive self regulation social functioning participants french schoolchildren followed kindergarten mage months months grade using hierarchical regression analyses three major findings revealed inhibitory control better predictor verbal working memory prosocial skills assessed peers using sociometric technique well teachers using questionnaires controlling sex mother education verbal non verbal prosocial skills assessed teachers kindergarten contributed explaining prosocial skills peer acceptance assessed grade cognitive self regulation sex moderate relationship cognitive self regulation social functioning results suggest developing strong cognitive self regulation especially inhibitory control prosocial skills young children schooled france could beneficial social development
background study evaluates benefits integrating behavioral health trauma services latinas history drug use changes quality life qol domains documented participation manualized intervention cohort latinas methods participants part prospective cohort study latinas occurring disorders cod may experienced trauma receiving services outpatient treatment facility bayamon puerto rico whoqol bref spanish version used score physical psychological social environmental qol domains intake six months sociodemographic variables alcohol drug use mental health disorders severity substance use disorders defined dsm also tabulated descriptive statistics paired test wilcoxon signed rank test computed comparison results median age years seen high school education higher degree majority unemployed diagnosis severe cocaine use present almost half three dsm diagnoses mean qol scores higher six months statistically significant differences domain women neurodevelopmental disorders schizophrenia yielded higher mean qol scores domain six months except social domain women polydrug use women reported exposure trauma depressive disorder experienced statistically significant increments physical psychological social domains comparison counterpart women conclusions significant positive changes qol found domain latinas reported traumatic events lower scores physical psychological qol domains high prevalence diminished physical mental functioning latinas cod exposure trauma lack social support negatively affect treatment access retention latinas
recently increase use finite control set model predictive control fcs mpc power converters model predictive control mpc uses discrete time model system predict future values control variables possible control actions computes cost function related control objectives control technique provide fast dynamic response however mpc method implementation imposes high computational burden causes significant hardware requirements real time implementation paper fully field programmable gate array fpga based real time implementation mpc proposed direct matrix converter dmc proposed method control calculations safe commutation scheme dmc fully implemented fpga need another digital control platform digital signal processors dsp dspace eliminated proposed scheme takes full advantages parallel computation capability fpgas
severe fungal infection affecting head lateral line system diagnosed captive scalloped hammerhead sharks sphyrna lewini aquarium thailand extensive severe necrotizing cellulitis consistently observed microscopically along cephalic lateral line canals conjunction positive fungal cultures fusarium molecular phylogenetic analysis performed isolates based nucleotide sequences containing internally transcribed spacer portion rdna fungus highly homologous closely related solani species complex fssc belongs clade fssc results illustrate histopathological findings expand upon knowledge prevalence invasive fusariosis head lateral line system hammerhead sharks
exposure graphic warning labels gwls cigarette packaging found produce heightened activity brain regions central emotional processing higher order cognitive processes current study extends literature using functional magnetic resonance imaging fmri investigate neural activation response gwls use predict relapse evidence based smoking cessation treatment program participants treatment seeking nicotine dependent smokers completed fmri paradigm exposed gwls text warning labels tols matched control stimuli subsequently enrolled smoking cessation treatment smoking behavior monitored activation bilateral amygdala right dorsolateral prefrontal cortex right inferior frontal gyrus left medial temporal gyrus bilateral occipital lobe bilateral fusiform gyrus greater gwls tols neural response ventromedial prefrontal cortex vmpfc exposure gwls relative visual control image predicted relapse treatment beyond baseline demographic dependence severity response amygdala gwls findings suggest neurocognitive processes vmpfc may critical understanding gwl induce behavior change may useful predictor smoking cessation treatment prognosis
paper transfer function model heavy duty gas turbine developed load frequency control studies based large signal model rowen small signal model developed model much suitable automatic generation control proportional integral derivative secondary controller developed small large signal models improve system response ziegler nichols method simulated annealing fuzzy gain scheduling used tuning secondary controller ziegler nichols method used conventional tuning whereas simulated annealing search based tuning fuzzy gain scheduling adaptive found simulated annealing tuned proportional integral derivative controller yields better response two controllers large signal small signal model heavy duty gas turbine plant elsevier ltd rights reserved
local binary pattern lbp proved efficient local image descriptor used computer vision lbp operator successfully applied many biometrics applications face recognition one application performance degrades due varying illumination facial expressions head pose changes address issues effectively lbp operator used represent face images feature extraction however due limited number discriminative characteristics lbp operator address issues properly seeks distinctive well structured local feature representation paper reports face identification system makes use novel lbp variant called logically concatenated lbp basic notion modified lbp exploited combined three logical operations viz xor logical operations used produce three different labeled face patterns single face patterns used face matching identification proposed face identification tested fei umist extended yale face databases identification accuracies determined experimental results found encouraging convincing experimental results also compared existing local descriptors
increasing evidence suggest symptomatic overlap clinically significant degree occurrence autism spectrum disorders asd psychotic disorders schizophrenia nature relationships remain unclear reviewed literature reporting prevalence rates autistic like traits alts asd populations diagnosis schizophrenia psychotic disorder search three large databases conducted seven studies met criteria inclusion point prevalence rates alts ranged whilst prevalence rates diagnosed asd ranged across outpatient inpatient populations suggests prevalence rates alts asd psychosis populations much higher general population important implications regarding future research clinical implications terms ensuring patients receive appropriate diagnosis treatment
background hbac important parameter diagnosis diabetes however many factors independently influence hbac levels present study aimed determine affect hypothyroidism hbac level materials methods individuals selected study attended ameen medical college hospital december october applying inclusion exclusion criteria served cases control relevant investigations carried thyroid hormone replacement initiated hypothyroid cases reviewed weeks tsh hbac along relevant investigations repeated results total cases controls studied comparable mean age groups mean hbac hypothyroid cases controls difference means mild statistically significant mean tsh cases controls difference means statistically significant cases evaluated second visit statistically significant reduction mean tsh hbac thyroid replacement therapy compared pretreatment values cases conclusion hbac tsh levels found high non diabetic hypothyroid subjects compared normal controls drop levels hbac tsh initiation thyroid hormone replacement
variable ratio gearbox vrg enable small wind turbines operate discrete variable rotor speeds reliable low cost alternative require power conversion equipment case conventional variable speed previous work conducted author demonstrated vrg increase power production fixed speed system passive blades current study characterizes performance wind turbine equipped vrg active blades contribution work integrative framework optimizes power production blade root stress works defining set control rules specify vrg gear ratio pitch angle used relation wind speed three ratios selected proposed procedure case study based simulation wind turbine model performed demonstrate proposed technique model constructed aerodynamic mechanical electrical submodels drivetrain components work together simulate conversion moving air electrical power blade element momentum bem technique used compute blade loading resulting torque rotor speed reduced increased respectively mechanical system gearbox output applied electrical generator bem technique also used determine bending thrust loads applied blade stress root blade determined based loads caused centrifugal force gravity proposed method devises vrg design control algorithm based unique wind conditions given installation site two case studies conducted using wind data sets provided national renewable energy laboratory nrel low high speed data set selected inputs demonstrate versatility proposed method dynamic programming used reduce computational expense enables simulation exhaustive set potential vrg combinations set recorded wind data possible combination evaluated terms total energy production blade root stress produced simulation period set weights applied multi objective function computes cost associated combination pareto analysis used identify vrg combination establish control algorithm systems results suggest vrg improve energy production partial load region roughly cases although stress increases region decreases region overall optimal selection gear combinations
alpha nicotinic acetylcholine receptor nachr implicated many neuropsychiatric disorders making important target positron emission tomography pet imaging first aim work compare two alpha nachrs pet radioligands asem diazabicyclo nonan fluorodibenzo thiophene dioxide dbt diazabicyclo nonan fluorodibenzo thiophene dioxide nonhuman primates second aim assess quantification test retest variability asem humans pet scans high specific activity asem dbt acquired three rhesus monkeys one male two female kinetic properties radiotracers compared additional asem pet scans blocking doses nicotine varenicline cold asem acquired separately two animals next six human subjects five male one female imaged asem pet min arterial sampling used measure parent input function different modeling approaches compared identify optimal analysis method scan duration quantification asem distribution volume addition retest scans acquired four subjects three male one female test retest variability assessed rhesus monkey brain asem dbt exhibited highly similar kinetic profiles dose dependent blockade asem binding observed administration either nicotine varenicline change asem asem selected validation used humans accurate quantification asem humans achieved using multilinear analysis least min data acquisition resulting values ranging cerebellum thalamus test retest variability results confirm asem suitable radiotracer imaging quantification alpha nachrs humans
hereditary angioedema due inhibitor deficiency inh hae rare disorder characterized intermittent unpredictable episodes swelling cause disfigurement disability pain case laryngeal swelling risk death historical factors including intermittent nature disorder lack awareness ultra rare condition amongst medical personnel lack specialist centers limited treatment options contributed diagnosis treatment condition incorrect treatment attacks common even medical help sought lead reduced health seeking behavior alternative coping strategies sometimes even denial many families minority hae affected patients become serial emergency room attenders chronic pain ongoing requirement opiate based painkillers strategies incurred physical also psychological economic consequences last years new effective acute therapies made available also provided short term long term prophylaxis options together better understanding older prophylactic drugs improved awareness hae amongst general public family members physicians reduced long delay diagnosis increased number patients receiving effective date therapies improve physical impact disorder data impact treatment psychological outcomes scarce limited information available suggests access specialist advice treatment leads psychological well physical improvement hae also profound effects individual family economic output directly via absenteeism school work indirectly via lost opportunities economic improvements associated better treatments offset high cost new acute treatments resulting difficult pharmaco economic calculations worldwide cost considerations present potentially insurmountable barriers treatment many patients depending healthcare system individual country
inflammatory bowel diseases chronic conditions unknown etiology showing growing incidence prevalence several countries including italy although etiology crohn disease ulcerative colitis unknown due current knowledge regarding pathogenesis effective treatment strategies developed several guidelines available regarding efficacy safety available drug treatments inflammatory bowel diseases nevertheless national guidelines provide additional information adapted local feasibility costs legal issues related use drugs observations prompted italian group study inflammatory bowel disease ibd establish italian guidelines safety currently available treatments crohn disease ulcerative colitis guidelines discuss use aminosalicylates systemic low bioavailability corticosteroids antibiotics metronidazole ciprofloxacin rifaximin thiopurines methotrexate cyclosporine tnf alpha antagonists vedolizumab combination therapies guidelines based current knowledge derived evidence based medicine coupled clinical experience national working group editrice gastroenterologica italiana published elsevier ltd rights reserved
varicocele often surgically repaired due male infertility however recently linked low serum testosterone paper serves review current literature regarding varicocele subsequent repair serum testosterone twenty eight human studies identified fifteen showing improved serum testosterone repair majority studies demonstrated improvement preoperative testosterone levels low normal additionally multiple well designed studies control groups undergoing surgical repair demonstrated significant difference groups improvement less observed studies normal preoperative serum testosterone majority patients studied presenting infertility remains determined findings reproduced men without infertility findings suggest microsurgical varicocele repair improve serum testosterone men low levels preoperatively appropriately counseled men remains seen whether varicocele repair help prevent development low testosterone future patients risk developing low testosterone due varicocele
objective article consider discuss existing research theory concerning copycat problem behaviors copycat offending may applicable populations firesetting children adolescents primary databases used search literature psychinfo medline eric google scholar used additional internet search engine primary focus literature published since earlier literature considered important also included qualitative quantitative studies suggest consumption violent media affects aggressive behaviors supports existence copycat effect within offending populations existing literature suggests processes desensitization observational learning priming alteration scripts involved copycat behaviors mediated individual environmental media factors literature concerning firesetters largely overlooked possibility copycat effect given young age often antisocial nature individual environmental problems associated firesetters may population particularly vulnerable effect need consideration potential role media copycat behaviors care taken way media reports events
previous research demonstrated even brief exposures facial expressions emotions elicit facial mimicry receivers form corresponding facial muscle movements well vocal verbal patterns speakers converge conversations type vocal mimicry also evidence cross modal mimicry emotional vocalizations elicit corresponding facial muscle activity empathic capacity associated enhanced tendency towards facial mimicry well verbal synchrony investigated type potential cross modal mimicry simulated dyadic situation specifically examined influence facial expressions happy sad neutral emotions vocal pitch receivers potential association empathy results indicated whereas mean pitch variability pitch varied somewhat predicted directions empathy correlated difference variability pitch speaking sad neutral faces discussion results considers dimensional nature emotional vocalizations possible future directions
paper presents results eigenvalue analysis fatih sultan mehmet bridge high resolution finite element model created directly available design documents physical properties structural components included detail calibration measured data necessary deck towers modeled shell elements nonlinear static analysis performed eigenvalue calculation calculated natural frequencies corresponding mode shapes showed good agreement available measured ambient vibration data calculation effective modal mass showed nine modes single contributions higher total mass frequency range comparison results torsional modes especially demonstrated advantage using thin shell finite elements beam modeling approach
objective compare changes lipids lipid associated cardiovascular risk markers patients rheumatoid arthritis treated tocilizumab adalimumab methods post hoc analysis performed patients received tocilizumab intravenously every weeks adalimumab subcutaneously every weeks weeks adacta trial lipid lipid associated risk biomarkers including high density lipoprotein associated serum amyloid hdl saa secretory phospholipase iia spla iia lipoprotein measured baseline week results study included patients treated tocilizumab patients treated adalimumab hdl saa spla iia measured subpopulation patients respectively greater increases mean low density lipoprotein cholesterol ldl mmol high density lipoprotein cholesterol hdl mmol total cholesterol mmol triglycerides mmol hdl ratio occurred tocilizumab baseline weeks hdl saa spla iia decreased tocilizumab adalimumab median changes baseline week hdl saa spla iia difference adjusted means similar results observed efficacy responders non responders per american college rheumatology european league rheumatism criteria conclusion ldl hdl increased tocilizumab adalimumab hdl saa spla iia decreased tocilizumab lipid change effects interleukin tumour necrosis factor tnf inhibition manifest net impact lipids lipoproteins synonymous clinical significance unclear requires study trial registration number nct post results
paper semi analytical numerical models developed previous works study dynamic behaviour natural convection assessed experimental data obtained means natural circulation loop ncl dime tec labs university genoa experimental campaign reference made set nine experiments performed using water working fluid providing thermal power set data firstly adopted validation semi analytical linear analysis tool aimed studying asymptotic behaviour ncls definition dimensionless stability maps two different numerical models adopted previous work confirm linear analysis assessed namely object oriented one dimensional model three dimensional computational fluid dynamics cfd model regard model represents fast tool evaluation important quantities velocity temperature fields loop along axial coordinate hand cfd tool intended support analysis characterised high computational burden allows highlighting interesting spatial effects validation tools secondary respect stability maps actually numerical approach fundamental study time dependent behaviour stable unstable natural circulation regimes stability maps provide information achieved results developed models able catch behaviour experimental data particular outcome possible accurate modelling heat exchanger section piping thermal inertia considered elsevier ltd rights reserved
paper reports method simultaneous estimation unwrapped phase higher order phase derivatives single phase fringe pattern recorded optical interferometric setup thereby overcoming substantial barriers achieving measurements proposed method considers interference phase weighted linear combination gaussian radial basis functions defined along given row column time gaussian radial basis functions defined constant standard deviation equally spaced centers unscented kalman filter employed accurate estimation weights basis functions using state space representation spatial evolution interferogram estimated weights along numerically computed gradients basis functions also provide estimations phase derivatives arbitrary order proposed representation interference phase along unscented kalman filter provides high robustness speckle noise simulation study preformed evaluate dependence phase phase derivative estimation accuracy selection basis dimension noise level experimental results demonstrate practical applicability proposed method
article outlines trends ongoing reform moral education japan examining dealing problems issues arisen past practice moral education schools moral class incorporated elementary junior high school curriculum non subject lesson since course study revised upgrade moral class official subject order revamp moral education well children society focus reform described shift thinking discussion intention new subject encourage children think reflectively critically expected active learning discussion collaborative work problem solving enhance children abilities think deeply act proactively teacher education collaboration within society key realizing potential new subject
presence damage civil structure alters stiffness consequently modal characteristics identification changes provide engineers useful information condition structure constitutes basic principle vibration based structural health monitoring eigenfrequencies mode shapes commonly monitored modal characteristics sensitivity structural damage may low relative sensitivity environmental influences modal strains curvatures could offer attractive alternative current measurement techniques encounter difficulties capturing small strain sub microstrain levels occurring ambient operational excitation sufficient accuracy paper investigates ability obtain sub microstrain accuracy standard fiber optic bragg gratings using novel optical signal processing algorithm identifies wavelength shift high accuracy precision novel technique validated extensive experimental modal analysis test steel beam instrumented fbg sensors top bottom flange raw wavelength fbg data processed strain values using novel correlation based processing technique conventional peak tracking technique subsequently strain time series used identifying beam modal characteristics finally accuracy algorithms identification modal characteristics extensively investigated
objective aim study investigate whether early alterations evoked potentials eps prognostic value relapsing remitting multiple sclerosis rrms methods retrospectively selected early patients neurological follow ranging years multimodal eps visual brainstem auditory somatosensory motor performed diagnosis conventional ordinal score used quantify observed abnormalities results extent change composite score well correlated expanded disability status scale edss ten years years disease onset analysis predictive value score showed increased risk disability progression conversely risk disability progression associated lower score reduced respectively conclusions data support good predictive value long term disability progression multimodal eps performed early disease onset rrms patients significance study performed homogeneous rrms cohort long term follow demonstrates value early comprehensive neurophysiological assessment marker future disability international federation clinical neurophysiology published elsevier ireland ltd rights reserved
construction management water conservancy project characteristics wide range multi field includes construction process management measures completion inspection acceptance management series problems construction management water conservancy project present stage quality control security administration therefore corresponding measures taken solve urgent problems process water conservancy project construction proprietor supervise monitor contractor establish improve system safety management formulate strict safety supervision system strengthen contract management quality management water conservancy construction
current state knowledge psychological stress management among patients suffering temporomandibular joint dysfunction well lack educational projects aimed patient group available literature became inspiration develop psychoeducational programme aim programme provide basic information contribution stressors aetiology temporomandibular joint dysfunction educate methods coping stress commonly used psychology purpose study compile programme validate usefulness study population group patients aged usefulness psychoeducation training assessed via questionnaire baseline survey month psychoeducation programme survey preliminary results suggest programme improves emotional state patients receiving prosthetic treatment temporomandibular disorders
several frameworks dynamic analysis wind vehicle bridge systems presented past decade study safety ride comfort road vehicles pass bridges crosswinds wind loads vehicles generally formed based aerodynamic parameters stationary vehicles ground wind loads pure bridge decks without effects road vehicles studies carried explore dynamic effects aerodynamic interference road vehicles bridge decks particularly moving road vehicles study aerodynamic parameters moving road vehicle deck considering mutually affected aerodynamic effects formulized firstly corresponding wind loads road vehicle bridge system obtained refined analytical framework wvb system incorporating resultant wind loads driver model road roughness plane fully consider lateral motion road vehicle crosswinds proposed shown obvious lateral yaw motions road vehicle occur selected single road vehicle passing long span bridge slight effects caused aerodynamic interference moving vehicle deck dynamic responses system
isogeometric analysis iga introduced hughes exploits one mathematical basis representation computer aided design cad geometry analysis entire engineering process paper extend concept also visualization presented post processing visualization techniques thereby strengthen relation geometry analysis visualization achieved facilitating mathematical function space used geometry analysis also post processing visualization purposes non linear analysis derivatives incrementally computed stored different basis function representations introduce investigate projection methods able use function space displacements stresses without loss accuracy obtain common representation structured unstructured meshes like hierarchical spline locally refined spline spline spline techniques exploit bezier decomposition post processing step resulting bezier element representation constitute generalized representation typically used unrelated fictitious finite element mesh representation visualization purposes easily replaced without changing underlying geometry well algorithmic data structure one benefit used bezier decomposition lies fact facilitates natural parallel implementation graphics processor units gpus exploiting shader programming paper developed investigated accurate efficient practical post processing pipeline visualization isogeometric analysis results proposed iga visualization pipeline consists three steps projection bezier decomposition pixel accurate rendering tested four different projection methods description perform bezier decomposition splines given whereas hierarchical splines done furthermore use gpu shader programming enable efficient pixel accurate visualization detailed performance four different projection techniques tested manufactured problems well realistic benchmark problems furthermore iga visualization pipeline demonstrated number real world applications author published elsevier open access article license http creativecommons org licenses
trang phuc linh plus tplp food supplement product derived dried extracts herbal agents atractylodes macrocephala poria cocos paeonia lactiflora phellodendron amurense added lactobacillus fermentum lysate immunegamma hydroxytryptophan tplp functional food used adjunctive treatment treating irritable bowel syndrome ibs however biological effect mechanism action ibs elucidated study aimed determine pharmacological activities mode action tplp ibs animal models mice given single administration mustard oil intracollonically acute colitis induction resulted later development ibslike accelerated upper gastrointestinal transit inmice mice treated different tplp controls results showed tplp dose day given orally significantly decreased intestinal motility compared control animals effect similar duspatalin day mebeverine hydrochloride antispasmodic helps relieve pain discomfort associated gastrointestinal spasms increased tplp dose day better effect relief duspatalin day tplp also reduced peristalsis frequency decreased fluid volume electrolytes excretion intestine tested vivo models overall tplp may effective nutraceutical supplement ibs
cyclic dipeptides cdps heterocyclic diketopiperazines exceptional structural rigidity enzymatic stability biological activity exhibiting substantial tendency take part intermolecular interactions strong intermolecular interactions driven unique hydrogen bonding patterns render cdps high propensity undergo molecular self assembly review aim provide comprehensive summary design strategies used engineer molecular self assembly cdps functional nano micro architectures molecular gels potential applications biomedical materials engineering fields
background prevalence diabetic nephropathy varies according ethnicity environmental well genetic factors contribute heterogeneity presentation diabetic nephropathy objective evaluate heterogeneity within caucasian population methods geo ethnic origin genotyped caucasian type diabetes patients action diabetes vascular disease preterax diamicron controlled evaluation determined using principal component analysis genome wide association studies analyses age onset performed geo ethnic groups separately combined results first principal component separated caucasian study participants slavic celtic ethnic origins age onset diabetes significantly lower slavic patients whereas prevalence hypertension albuminuria significantly higher age onset albuminuria appear important genetic component values traits also different slavic celtic individuals living countries common geo ethnic specific loci found associated age onset diabetes among latter prox prox genes highest impact single nucleotide polymorphism genotype associated year earlier onset slavic patients living countries predominant slavic populations conclusion results reveal presence distinct genetic architectures caucasian ethnic groups likely clinical relevance among prox gene strong candidate early onset diabetes variations depending ethnicity
sprays described kinetic disperse phase model strongly coupled navierstokes equations resolution strategy constrained accuracy objectives robustness needs computing architecture order leverage good properties eulerian formalism introduce deterministic particle based numerical method solve transport physical space simple adapt many types closures moment systems method inspired semi lagrangian schemes developed gas dynamics show semi lagrangian formulations relevant disperse phase far equilibrium particle particle coupling barely influences transport particle pressure negligible particle behavior indeed close free streaming new method uses assumption parcel transport avoids compute fluxes limiters makes robust deterministic resolution method require efforts statistical convergence noise control post processing couplings done among data form eulerian fields allows one use efficient algorithms anticipate computational load makes method accurate efficient context parallel computing complete verification new transport method various academic test cases demonstrate overall strategy ability solve strongly coupled liquid jet fine spatial resolution apply case high fidelity large eddy simulation dense spray flow fuel spray simulated atomization diesel engine combustion chamber conditions large parallel strongly coupled computation proves efficiency method dense polydisperse reacting spray flows elsevier inc rights reserved
health risks drinking rainwater relatively small developing world context action needed ensure water safety water safety plans wsps use approach manage water quality shown signs success public communal water supplies relatively little research done investigate application wsps self supply systems aim paper investigate primary issues surrounding appropriate water quality management domestic rainwater harvesting drwh systems fiji consider principles wsps applied context qualitative research design followed utilising semi structured interviews rural households six key informants sanitary inspections drwh systems thematic data analysis number challenges including limited government resources limited knowledge casual attitudes rural rainwater consumers constrain practicality adopting conventional wsps household level steps improvement taken
agomelatine melatonergic antidepressant rapid onset action one recent drugs antidepressant category agomelatine antidepressant actions attributed sleep promoting chronobiotic actions mediated receptors present suprachiasmatic nucleus well effects blockade htc receptors blockade htc receptors causes release noradrenaline dopamine fronto cortical dopaminergic noradrenergic pathways combined actions agomelatine htc receptors facilitate resynchronization altered circadian rhythms abnormal sleep patterns agomelatine appeared effective treating major depression moreover evidence exists points possible efficacy drug treatment bipolar depression anxiety disorders alcohol dependence migraines etc thus aim narrative review elucidate current evidences role agomelatine disorders major depression
approach mass measurement electronic balance based continuous time sigma delta sigma delta modulator described paper effect multifarious interfering noises accuracy electronic balance restricted general idea proposed approach apply electromagnetic force compensated load cell emcc related signal processing circuit composite filter circuit mainly consists proportional integral differential controller pulsewidth modulator combine emcc form sigma delta modulator sigma delta modulator possesses inherent antialiasing filtering oversampling noise shaping characteristics interfering noises effectively removed composite filter composed two sinc filters simulations electronic balance models adopting proposed approach working conventional pulse current mode analyzed adding white gaussian noise simulink simulation results demonstrate effectiveness proposed approach proposed electronic balance field improve signal noise ratio testing results meet requirement weighing accuracy special class scale defined organisation internationale metrologie legale nonautomatic weighing instruments
temporary anaesthesia analgosedation used awake craniotomies carry substantial risks like hemodynamic instabilities airway obstruction hypoventilation nausea vomiting agitation interference test performances tested actual need sedatives opioids patients undergoing awake craniotomy brain tumour resection eloquent motoric brain areas cranial nerve blocks permanent presence contact person therapeutic communication provided therapeutic communication based assumption patients extreme medical situation enter natural trance like state elevated suggestibility anaesthesiologist acted continuous guide using strong rapport nonverbal communication hypnotic suggestions dissociation safe place reframing disturbing noises simultaneously avoiding negative suggestions analgesics sedatives hand according principle much necessary needed sedation necessary patients besides treatment seizures two thirds patients requested remifentanil mean dosage end tumour resection total hemodynamic reactions indicative stress mainly seen nerve blockades neurological testing postoperative vigilance tests showed equal higher scores preoperative tests main challenges patients undergoing awake craniotomies include anxiety fears terrifying noises surroundings immobility loss control feeling helplessness left alone situations psychological support might helpful pharmacological approach adequate therapeutic communication patients require sedation low dose opioid treatment awake craniotomies leaving patients fully awake competent entire surgical procedure without stress approach termed awake awake awake technique
objective aim present study investigate associations reproductive factors survival age years methods prospective study postmenopausal women women health initiative recruited followed last outcomes evaluation august participants included women born august survival age follow ascertained women classified survived age exceptional longevity died age multivariable logistic regression models used evaluate associations ages menarche menopause natural surgical reproductive lifespan longevity adjusting demographic lifestyle reproductive characteristics results participants average aged years range baseline women survived age women aged least years menarche modestly increased odds longevity odds ratio significant trend toward increased longevity later age menopause natural surgical trend ors cis least compared less years respectively later age natural menopause separate exposure also significantly associated increased longevity trend longer reproductive lifespan significantly associated increased longevity trend odds longevity higher women compared less reproductive years conclusions reproductive characteristics associated late age survival older women
background european association palliative care eapc recently issued framework defines optimal palliative care dementia however implementation guidelines may pose challenges physicians working dementia patients practice objective measure compare perceptions physicians two european regions regarding importance challenges implementing recommendations optimal palliative care dementia patients design cross sectional observational study setting netherlands united kingdom subjects physicians providing palliative care patients dementia measurements postal survey results physicians netherlands northern ireland united kingdom prioritized domains optimal palliative care dementia match priorities eapc endorsed guidelines respondents countries rated lack education professional teams lack awareness general public among important barriers providing palliative care dementia respondents also identified access specialist support barrier results indicate strong consensus among experts elderly care physicians general practitioners across variety settings europe person centered care involving optimal communication shared decision making top priority delivering optimal palliative care dementia conclusions current findings support enhance new recommendations ratified eapc take forward implementation eapc guidelines palliative care dementia necessary assess challenges thoroughly country specific level design test interventions may include systemic changes help physicians overcome challenges
hepatitis virus hcv major cause chronic liver disease worldwide due asymptomatic nature infection many acute cases hcv infection left undiagnosed screening individuals risk important public health priority new medications offer sustained virologic response rates fewer adverse reactions shorter durations therapy article reviews new treatment guidelines evaluation management patients hcv infection
objectives study aims determine optimal tolerability dose ranges risperidone ris olanzapine olz administered schizophrenia maintenance phase methods two year continuation rates prescription discharge examined using retrospective cohort study method adult patients schizophrenia related psychotic disorders receiving antipsychotic monotherapy ris olz discharge included primary outcome measures time treatment discontinuation year continuation rates modal dose ranges drug estimated optimal tolerability dose ranges comparing continuation rates various modal doses results patients received ris received olz ris year continuation rates daily modal dose ranges significantly different difference favoring ris lower doses higher doses contrast significant differences among olz modal dose ranges time treatment discontinuation significantly favored olz ris however significantly differ ris olz lower doses conclusions suggested optimal tolerability dose range maintenance treatment ris olz ris lower doses comparable olz lower doses
paper emphasis best efforts technique reduction harmonic content sinusoidal waveform voltage done increasing number steps general number bridges determined formula levels number bridges leads bridges research makes use bridges achieved making use asymmetrical multilevel inverter different voltage source also use pwm eliminated reduces harmonic content waveform
deformation asymmetry magnesium alloys important factor machine design automobile industry represented ratio compressive yield stress cys tensile yield stress tys deformation asymmetry strongly related texture grain size polycrystalline viscoplasticity model modified intermediate phi model used predict deformation behavior magnesium alloys different grain sizes validated experimental results integrated computational materials engineering applied find route achieving desired asymmetry via thermomechanical processing example cys tys rolled texture smaller different loading directions textures extruded texture cys tys large along normal direction starting rolled texture asymmetry increase close along rolling direction compressed strain modified phi model also shows grain refinement increases cys tys along texture control grain refinement also optimize yield asymmetry grain size decreases critical value cys tys reaches cys increases much faster tys tailoring microstructure using texture control grain refinement achievable optimize yield asymmetry wrought magnesium alloys published elsevier
jurors asked use personal knowledge experience make verdict decisions thus surprise religious beliefs might influence decisions legal insanity trials jurors might also exposed religious stimuli crucifix prayer bible etc could evoke prime religious beliefs thus influence decisions two studies examined whether dimensions religiosity religious beliefs relate attitudes decisions concerning mental health defenses testing social identity theory allport ross religiosity hypothesis study attitudes survey study mock juror decision making paradigm religious fundamentalist beliefs consistently predicted punitive attitudes decisions related mental health defenses verdicts moderated intrinsic religiosity religious fundamentalist beliefs predicted punitiveness individuals low intrinsic religiosity also priming fundamentalist beliefs increased punitiveness verdict sentencing decisions combined results suggest religious beliefs play role jurors verdict decisions insanity case priming fundamentalist beliefs increases jurors punitiveness allport ross religiosity hypothesis supported social identity theory
purpose study evaluate role collapse degeneration articular cartilage patients osteonecrosis femoral head onfh sixteen hips patients four men eight women mean age years history systemic corticosteroid treatment studied using rho magnetic resonance imaging mri six hips collapsed onfh five non collapsed onfh five osteonecrosis controls using oblique coronal images divided articular surface necrotic femoral heads region necrotic bone necrotic zone another living bone living zone rho value evaluated zone mean rho value necrotic zone significantly higher collapsed onfh group non collapsed onfh group collapsed onfh group mean rho value significantly higher necrotic zone living zone non collapsed onfh group significant difference mean rho values necrotic living zones collapsed onfh group mean rho value necrotic zone interval pain onset mri examination positively correlated current rho mri study suggested degeneration articular cartilage onfh begins necrotic region collapse
mechatronic based embedded digital draft force wheel slip measuring devices developed includes load cell based dynamometer measure draft force hall sensor based magnetic pins mounted discs measure wheel slip amplifier amplify sensing unit signals dynamometer microcontroller process received load cells hall sensors data calculate draft force wheel slip display lcd screen well record data card module compare assess degree accuracy developed draft measurement system wheel slip measurement system system involving instrumented three point linkages developed measure draft force simultaneously non contact type radar sensor used validate wheel slip measurement system observed maximum variation draft forces observed developed strain gauge dynamometer also found close draft force values calculated asabe equation maximum variation wheel slip observed developed manual measured values developed devices simple construction mounted make model agricultural tractor implements developed devices much helpful educational institutions research needs drawbar performance studies elsevier rights reserved
essential hypertension affected genetic environmental factors polymorphism connexin genes found associated development hypertension however association polymorphism cxs investigated study aimed investigate association polymorphism connexin genes kazak han chinese xinjiang china polymerase chain reaction restriction fragment length polymorphism pcr rflp method matrix assisted laser desorption ionization time flight mass spectrometry maldi tof used analyze polymorphism genes kazak han patients well normotensive controls results showed significant differences frequencies different three genotypes alleles patients normotensive controls however kazak patients frequencies three genotypes respectively significantly different han patients han patients frequencies three genotypes respectively frequencies four genotypes statistical differences among kazak han patients normotensive controls results suggest polymorphisms genes may associated pathogenesis carrying genotypes may protect development
paper presents new optimization algorithm based human society intelligent contests fifa world cup international association football competition competed senior men national teams contest one significant competitions among humans people teams try hard overcome others earn victory competition one winner best position rather others paper introduces new technique optimization mathematic functions based fifa world cup competitions main difficulty optimization problems type interpreted specific manner world cup optimization wco algorithm number parameters solve type problems due defined parameters analyzing system performance applied benchmark functions also applied optimal control problem practical case study find optimal parameters pid controller considering nominal operating points changes avr system main objective proposed system minimize steady state error also improve transient response avr system optimal pid controller optimal values pid controller achieved wco algorithm compared particle swarm optimization imperialist competitive algorithm different situations finally illustrating system capability disturbance applied generator disturbance results compared algorithms simulation results show excellence wco algorithm performance nature base competitive algorithms
structurally simple water soluble rhodamine derivatived fluorescent probe responsive acidic conveniently synthesized via one step condensation reaction rhodamine hydrazide formybenzene disulfonate stable highly sensitive sensor probe displays approximately fold fluorescence enhancement range structure probe changes spirocyclic weak fluorescent ring open strong fluorescent decreasing synthesized fluorescent probe applied detection changes vitro vivo bioimaging immortalized gastric cancer cells satisfactory results
india production electricity thermal power plants accounts total electricity generated thermal power plants produce million tons per year coal ash waste materials improper disposal ash poses threat environment requires allocation vast land area dumping storing pollutes land ash generated thermal power plants falls two categories namely fly ash pond ash one ways minimize harmful effects due unsafe disposal ash environment utilize ash construction industry admixture brick making cement manufacture etc moreover conventional brick making precious natural soil resource overexploited one essential requirements green building use environmentally friendly building materials well reuse recycle industrial waste products like fly ash pond ash fly ash pond ash used optimally replacing clay brick manufacturing industry waste material treated greener material also reduce pressure excavation soil besides energy saving methodologies green building involves application technologies using materials without affecting natural resources investigation attempt made devise ways optimal use pond ash manufacturing coal ash bricks article presents experimental results coal ash brick made pond ash fly ash lime gypsum stone dust fundamental strength durability tests conducted evaluate basic properties bricks energy dispersive ray diffraction study scanning electron microscope sem study carried elemental analysis analyze chemical composition abovementioned materials
purpose samoan communities australia exhibit disproportionate rate kidney disease compared australians article describes research project used culturally sensitive framework afaletui help reduce barriers language culture increase understanding factors contributing kidney disease one samoan community australia design semistructured group interviews undertaken samoan community families groups interviews analyzed according key concepts embedded afaletui framework findings four factors associated health risks samoan community emerged diet exercise issues related collective incorporating village church family tapu cultural protocols importance language conclusions findings suggest future kidney health promotion initiatives within samoan community effective sensitive samoan cultural norms language context
background university rochester specialty pharmacy hepatitis patient management program offers unique advantage integrated within health system university rochester medical center urmc gastroenterology hepatology division objective primary purpose study assess treatment success incidence achieving sustained virological response svr patients served specialty pharmacy versus nonintegrated pharmacies methods single center retrospective cohort study adult patients urmc gastroenterology hepatology prescribed hepatitis treatment january july incidence svr adherence delay therapy initiation early treatment discontinuation rate attainment viral load measurement post therapy completion predictors associated treatment outcome assessed results total patients prescribed hepatitis virus treatment study period initiate therapy rate svr among patients specialty pharmacy nonintegrated pharmacies adherence therapy specialty pharmacy nonintegrated pharmacies respectively conclusions specialty pharmacy associated svr rate significantly greater adherence compared nonintegrated pharmacies larger studies needed determine significant difference svr exists integrated nonintegrated pharmacies study provides framework institutions justify developing integrated hepatitis specialty pharmacy services evaluate success
analysis detection human behaviors video sequences became recently hot research topic computer vision artificial intelligence indeed human behavior understanding plays fundamental role several innovative application domains smart video surveillance ambient intelligence content based video information retrieval however uncertainty vagueness typically characterize human daily activities make frameworks human behavior analysis hba hard design develop order bridge gap paper proposes hierarchical architecture based tracking algorithm time delay neural networks fuzzy inference systems aimed improving performance current mba systems terms scalability robustness effectiveness behavior detection precisely joint use aforementioned methodologies enables quantitative qualitative behavioral analysis efficiently face intrinsic people objects tracking imprecision provide context aware semantic capabilities better identifying given activity validity effectiveness proposed framework verified using well known caviar dataset comparing system performance similar approaches working dataset elsevier inc rights reserved
thermal hydraulics aerosols iodine thai facility located eschborn germany steel test vessel designed simulate operational accident conditions nuclear containment structure thai facility provides experimental data used validation thermal hydraulic codes test performed facility modeled using gothic software package purpose validating physical models modeling techniques test analyzed step international standard problem test performed thai facility test consisted three injection ports steam helium enter vessel axis axis injection locations along compartmented geometry facility provide complex coupling physics would present accident transient inside containment typical light water reactor key considerations analysis stratification steam helium condensation deposition flow patterns within vessel
study aims mathematical modeling mechanism solar tracker system two axes well modeling stepper motors drive axis get best angle incidence sun photovoltaic plate proposed architecture modeled using conversion method kinetic energy potential lagrange stepper motors modeled detailed analysis internal characteristics ready models used software matlab perform simulations order view system response step engine speed high system response oscillatory need using pid controls system improve system position control efficiency used second method ziegler nichols determining parameters pid controller gains thus system modeling completed fine tuning pid controller order find best values controller parameters using embedded system arduino uno
therapeutic relationship particular importance working patients antisocial personality disorder despite paucity literature exploring student nurses perceptions developing therapeutic relationship patients hence qualitative study explored perceptions second year mental health nursing students developing therapeutic relationship patient group student nurses university northwest england participated two focus groups compare perceptions group student nurses experience secure settings forensic hospital four key themes emerged diagnosis safety engagement finally environmental influences groups commented looking beyond diagnosis seeing person student nurses cited staff clinical placement areas hugely influential terms development perceptions patients antisocial personality disorder relate
fearful faces capture attention hold however little known time course capture hold spatial attention fearful emotional faces three dot probe studies examined time course experiments used fearful neutral faces experiment dot probe targets occurred post face onset experiment dot probe targets occurred post face onset experiment conditions reaction times fastest congruent trials slowest incongruent trials reaction times baseline trials falling two pattern found conditions experiment later time points experiments significant differences conditions examine whether time course unique fearful faces third dot probe experiment using time points identical experiment conducted happy neutral faces results experiment suggest happy faces captured held attention conditions together results indicate attention captured held fearful faces times earlier approximately happy faces also captured held attention slightly different time course
duo general user friendly program computing rotational rovibrational rovibronic spectra diatomic molecules duo solves schrodinger equation motion nuclei simple case uncoupled isolated electronic states typical ground state closed shell diatomics also general case arbitrary number type couplings electronic states typical open shell diatomics excited states possible couplings include spin orbit angular momenta spin rotational spin spin corrections due non adiabatic effects accounted introducing relevant couplings using called born oppenheimer breakdown curves duo requires user specified potential energy curves relevant dipole moment coupling correction curves computes energy levels line positions line intensities several analytic forms plus interpolation extrapolation options available representation curves duo refine potential energy coupling curves best reproduce reference data experimental energy levels line positions duo provided fortran program tested variety operating systems program summary program title duo catalogue identifier aezj rogram summary url http cpc qub summaries aezlv html program obtainable cpc program library queen university belfast ireland licensing provisions standard cpc licence http cpc qub licence licence html lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language fortran computer personal computer operating system linux windows mac code vectorized parallelized parallelized ram case dependent typically classification nature problem solving schrodinger equation nuclear motion diatomic molecule arbitrary number type couplings electronic states solution method solution uncoupled problem first basis set truncation solution coupled problem line list computed dipole moment function provided potential energy curves empirically refined fitting experimental energies frequencies provided restrictions current version restricted bound states system unusual features user supplied curves objects potential energies spin orbit couplings dipole moment etc analytic functions grid program requirement running time case dependent test runs provided take seconds minutes normal elsevier rights reserved
challenges modeling unsteady lift two dimensional naca airfoil oscillating translating large incidence angles investigated paper forced oscillation motions two reduced frequency values used cfd results show hysteresis loop developed lift variation angle attack shapes loops change significantly reduced frequency value dynamic stall vortex identified pitching plunging motions vortex delays onset flow separation upper surface higher incidence would occur steady conditions unsteady lift fast motion enhanced significantly due formation compression wave lower surface expansion wave upper surface results show clear limitations unsteady aerodynamic theories modeling motions high incidences also cfd solution indicial functions show large oscillation angles attack beyond stall angle predictions model based radial basis function matches cfd values quite well elsevier masson sas rights reserved
power line parameters important factor relay applications power quality studies literature phasor measurement unit method measuring current voltage two ends power line usually used estimate power line parameters study parallel resonance impedance detection method used estimate power line parameter obtain input data real measurement values used obtain parallel resonance impedance method real measurement values include measurement errors current voltage transformer thus estimated parameter values realistic electrical network busbars belongs organized industrial zone turkey used application harmonic measurement power line electrical network made obtain parallel resonance impedance obtained parallel resonance impedance used maximization problem maximization problem defined estimated accuracy rate solved using clonal selection algorithm genetic algorithm particle swarm optimization make realistic parameter estimation methods defined parameter estimators selected used widely electrical engineering problem solutions results methods compared real parameter values accuracy estimate determined method
clinicians encouraged collect feedback patients ongoing patient report questionnaires monitor treatment response assess change instruments rely patient self reporting functional impairment distress corresponding changes presents particular challenges working individuals diagnosed personality disorder due nature psychopathology pragmatic solution clinician notice certain affective defensive cognitive markers serve observable indicators emerging change patient personality organization identify three markers signal anxiety repression mentalization proposition illustrated clinical material case adult patient diagnosed borderline personality disorder treated using psychoanalytic psychotherapy excerpts psychotherapy session analyzed providing qualitative description evaluation change personality organization borderline patient highlighting feasibility assessing change real world psychotherapy context
present study multi dimensional cfd computational fluid dynamics combustion simulations internal combustion engines new optimized chemical kinetic reaction mechanism oxidation prf primary reference fuel instead gasoline developed order carry depth research combustion phenomenon internal combustion engines optimized reduced prf mechanism including intermediate species radicals developed developed mechanism contains iso octane heptane surrogates contains species reactions compared many mechanisms prf reactions oxidation reactions added present mechanism order improve performances model developed mechanism focused improvement prediction ignition delay time developed mechanism validated various experimental simulation data including shock tube data laminar flame speed data hcci homogeneous charge compression ignition engine data results showed developed prf mechanism agreements experimental data approved reduced mechanisms could applied multi dimensional cfd simulations internal combustion engines elsevier ltd rights reserved
glycosaminoglycans gags play important roles various biological processes cell adhesion signal transduction well promote anti inflammatory activity previously revealed glycol split heparin aliphatic amine conjugates form self assembled nanoparticles suppress production pro inflammatory cytokines tumor necrosis factor tnf alpha interleukin beta lipopolysaccharide lps stimulated macrophages much strongly native control release babazada considering gag anti inflammatory activity present study initiated examine whether conjugation gags aliphatic amines generally effective activity augmentation lps stimulated macrophages newly synthesized stearylamine conjugates chondroitin sulfate hyaluronic acid low molecular weight heparin investigated effect position degree sulfation molecular weight gags anti inflammatory activity conjugates formed self assembled nanoparticles aqueous solution value suppression tnf alpha production macrophages smallest derivative followed degree sulfation appeared important determining anti inflammatory activity would correspond previous results using derivatives site selectively desulfated comparison derivatives revealed fractionated smaller heparin greater anti inflammatory activity
early diagnosis pancreatic exocrine insufficiency pei hindered many functional diagnostic techniques used expensive require specialized facilities prevent widespread availability reviewed current evidence order compare utility functional diagnostic techniques fecal elastase test following three scenarios screening pei patients presenting symptoms suggestive pancreatic disease abdominal pain diarrhea determining presence pei patients established diagnosis pancreatic disease chronic pancreatitis cystic fibrosis determining exocrine status disorders commonly tested pei known association disorder evidence suggests test reliable evaluation pancreatic function many pancreatic non pancreatic disorders non invasive less time consuming unaffected pancreatic enzyme replacement therapy although considered gold standard method functional diagnosis pei advantages test make appropriate test screening patients may risk disorder
aid theoretical calculations series molecularly imprinted polymers mips designed prepared recognition dicyandiamide dcd via precipitation polymerization using acetonitrile solvent basis long range correction method simulated bonding sites bonding situations binding energies imprinted molar ratios mechanisms interaction dcd functional monomers among acrylamide methylenebisacrylamide mba itaconic acid methacrylic acid maa maa confirmed best functional monomer strongest interaction maximum number hydrogen bonds lowest binding energy occurs dcd maa optimal molar ratios dcd functional monomers used respectively additionally pentaerythritol triacrylate peta confirmed best cross linker among divinylbenzene dvb ethylene glycol dimethacrylate egdma trimethylolpropane trimethylacrylate trim peta due facts weakest interaction highest binding energy occurs peta dcd strongest interaction lowest binding energy occurs peta maa depending results theoretical calculations series mips prepared among ones prepared using dcd maa peta template functional monomer cross linker respectively exhibited highest adsorption capacity dcd apparent maximum absorption quantity dcd mip
background blastocystis one common parasites reported human animals parasite prevalent regions low levels hygiene close contact animal unsuitable disposal systems aim study subtype blastocystis isolated diarrheic non diarrheic patients using sequencing ribosomal dna methods totally stool samples collected diarrheic non diarrheic patients referred imam reza hospital tehran apr aug samples concentrated using conventional formalin ether technique recognized light microscope fresh stool samples also cultivated clotted fetal bovine medium examined growing blastocystis every direct smear slides dna extraction performed positive samples amplified dna fragment rdna sequenced compared reference genes previously deposited genbank database results number diarrheic non diarrheic patients participated study respectively three subtypes identified positive samples subtype prevalent followed subtype subtype mixed subtypes furthermore prevalent subtypes diarrheic non diarrheic patients subtype subtype respectively conclusion blastocystis one prevalent unicellular parasites among diarrheic non diarrheic patients indeed prevalent subtype particularly samples collected diarrheic patients
bullous pemfigoid autoimmune disorder also induced medications vildagliptin new drug used treat diabetes mellitus recently cases vildagliptin induced described literature report patient vildagliptin thought possible causative agent awareness development risk gliptin therapy prevent unnecessary usage systemic drugs serious side effects
paper proposes studies nonparametric system identification foil air bearing fab research motivated two advantages removes computational limitations replacing air film foil structure equations displacement force relationship capture complications easily modeled identification based empirical data recurrent neural network rnn trained identify full numerical model fab wide range speeds variable speed rnn fab model successfully validated benchmark results two ways subjecting different input data sets using harmonic balance solution process unbalance response rotor bearing system either case results identified variable speed rnn maintain good correlation benchmark wide range speeds contrast earlier identified constant speed rnn demonstrating great potential method absence self excitation effects
paper explicit model predictive control mpc two stage turbocharged diesel engine presented mpc provides superior performance conventional map based pid boost pressure control easily adapted multivariable control relatively easy tune control oriented multiple input multiple output model turbocharged diesel engine derived using system identification methods mpc control design based linear model validation controller carried using high fidelity nonlinear engine model using high fidelity simulation model provides opportunity fine tune controller real time testing experimental real time tests demonstrate superior control performance wider range compared performance obtained using conventional control
polymer electrolyte membrane pem fuel cell system considered ideal alternative internal combustion engine especially used city bus hybrid buses fuel cell systems energy storage systems undergoing transit service demonstrations worldwide hybrid pem fuel cell city bus hierarchical control system studied paper firstly powertrain hierarchical control structure introduced secondly vehicle control strategy including start stop strategy energy management strategy fuel cell control strategy including hydrogen system air system control strategies described detail finally performance fuel cell analyzed based road test data results showed different subsystems well coordinated component functioned concert order ensure safety speed requirements satisfied output current fuel cell system changed slowly output voltage limited certain range thereby enhancing durability fuel cell furthermore economic performance optimized avoiding low load conditions
aimchildhood maltreatment related persistent reprograming stress response copeptin marker hypothalamic pituitary adrenal axis activation however studies examined copeptin levels children exposed aim study compare serum copeptin levels children reporting child abuse neglect children history methodsthis study included children positive history moderate severe reported parent clinical interview children history comparison group considered moderate severe based child reported frequency exposed events related sexual abuse physical abuse emotional abuse emotional neglect physical neglect child psychopathology symptoms assessed using child behavior checklist cbcl measured serum copeptin concentration using enzyme linked immunosorbent assay resultschildren exposed exhibited higher levels serum copeptin compared children without controlling sex age psychiatric morbidity cbcl total score including internalizing externalizing symptoms higher children found correlation copeptin cbcl scores internalizing symptoms externalizing symptoms conclusion associated copeptin serum levels independently age sex symptom severity copeptin promising new biomarker children history abuse neglect
paper details analysis design air core permanent magnet based energy harvest system use within pipe mobile water quality sensor sensor free moving free rotating device energy harvest system occupies appreciable volume therefore electrical mechanical dynamics device strongly coupled poses modeling challenge address challenge rigorous electrical mechanical model established determine expected energy harvest given geometric material parameters electrical mechanical inputs model utilized within single objective optimization maximizing energy harvested impacts design prototype constructed used model validation subsequently multiobjective optimizations performed establish tradeoff energy harvest versus device volume impact based versus rolling based energy harvest efficacy
systematic way transcribing schematic integrated circuit signal flow graph sfg equivalence presented sfg transfer functions loop gains input output impedances readily computed analysis valid multiloop amplifiers computation three stage amplifier nested miller compensation presented illustrate robustness method two theorems sfg relating stability networks also derived
performance onsite rainwater harvesting rwh system mediterranean climate assessed stochastic model quantifying necessary storage function rainfall frequency depth roof area residents number specific water use toilet flushing laundry required efficiency developed two performance indicators calculated water saving efficiency rse proportion water used supplied rwh system rainwater use efficiency rue proportion rainwater actually used maximum storage capacity wse decreased increasing number residents given roof area increasing roof area constant number residents variable storage volume rue increased increasing storage capacity reached maximum increase residents number decrease roof area model enables determine wse rue specific storage volumes determine desired wse calculate necessary storage
background inflating balloon foley catheter urethra complication urethral catheterisation report five patients complication occurred unskilled catheterisation due lack awareness problem recognised promptly patients came harm case series tetraplegic patient developed pain lower abdomen became unwell transurethral catheterisation pelvis revealed full bladder balloon foley catheter dilated urethra routine ultrasound examination asymptomatic tetraplegic patient urethral catheter drainage revealed foley balloon urethra advised get catheterisations done senior health professionals paraplegic patient developed bleeding bypassing transurethral catheterisation ray revealed foley balloon urethra urethral catheter changed ensuring correct placement urinary bladder subsequently balloon foley catheter inflated urethra several times community nurses resulted erosion bulbous urethra urinary fistula suprapubic cystostomy performed tetraplegic patient developed sweating increased spasms following urethral catheterisations abdomen revealed distended bladder balloon foley catheter located urethra flexible cystoscopy transurethral catheterisation guide wire performed patient noticed decrease sweating spasms paraplegic patient developed lower abdominal pain nausea following catheterisation abdomen revealed bilateral hydronephrosis hydroureter foley balloon located urethra urehral catheterisation performed guide wire cystoscopy subsequently suprapubic cystostomy done conclusion spinal cord injury patients increased risk intra urethral foley catheter balloon inflation lack sensation urethra urethral sphincter spasm false passage due previous urethral trauma education training doctors nurses proper technique catheterisation spinal cord injury patients vital prevent intra urethral inflation foley catheter balloon spinal cord injury patient develops bypassing symptoms autonomic dysreflexia following catheterisation incorrect placement urethral catheter suspected
phase dynamics phase noise coupled phase locked loops plls independent oscillators analyzed phase noise coupled plls independent oscillators analyzed using signal flow graph mason gain rules near carrier phase noise pll elements array reduced single independent without coupling vco pll element return free running phase noise far carrier frequency provided coupling network reciprocal feedback loop gain pll elements large phase detector amplifier noise neglected phase dynamics noise improvement coupled pll arrays verified using two coupled plls independent gaas mesfet oscillators operating band
target research determine program slicing contributes program comprehension enhance functionality applying slicing tree concept implementation slicing tree concept refers automatically repeating program slicing slicing criterion changeable program decomposes atomic parts using technique offers several advantages traditional program slicing first facilitates process understanding original slicing even slicing number lines remains excessive easy understanding using slicing trees final nodes tree point relatively small fragment code starting point understand program behavior words bottom approach comprehension process becomes faster easier furthermore much easier use knowledge based recognizing patterns smaller fragments code recognizing patterns play great role comprehending code intuiting intention behind third method answers programmer question deciding next best slicing criteria next step since chosen automatically efficiently applied slicing tree concept several program codes containing basic programming functions analyze efficiency technique contribution improve program comprehension
large scale parallel computing system becoming failure prone due increasing number computational nodes results serious reliability problems parallel computing ensure successfully running parallel tasks meta tasks dag tasks necessary perform reliability analysis scheduling parallel tasks meta tasks key factors discussed affect impede successful execution single task reliability formula meta tasks presented dag tasks hardware failures software failures network link failures subtask execution order taken account shall calculate reliability subtasks also reliability network communication two reliability algorithms dag tasks designed finally experiments conducted experimental results show reliability analysis methods effective comprehensive
currently museums provide visitors interactive tour guide applications installed mobile devices provide timely tailor made multimedia information exhibits display paper argue mobile devices could provide help visitors also museum staff goal integrate within system multimedia tour guides management facilities required museums paper present imuseuma intelligent museum agents mobile based solution customize visits perform context aware management tasks imuseuma follows agent based approach makes possible interact easily museum environment make decisions based current status system currently deployed museum informatics informatics school university malaga main contributions mobile application provides management facilities museum staff means sensing processing environmental data providing integrated solution visitors tour guides museum staff allows coordination communication enrichment among different groups users iii using benefiting group communication heterogeneous groups users created demand
stone columns installed extremely soft soils may significantly reduce effectiveness treatment due insufficient lateral confinement provided soft soil encasement columns geotextiles commonly used cases satisfactory results thanks extra confinement provided geotextile column influence encasement behavior stone columns studied means drained triaxial tests performed encased non encased samples gravel two different densities gravel two different geotextiles tested study focused increase strength encased samples compared non encased ones extra confining pressure provided geotextiles mobilized friction angle gravel results show improvement achieved gravel encased geotextiles effect significant lower confining pressures elsevier ltd rights reserved
purpose relocation utilities major source delay indian infrastructure projects delay particularly critical road bridge construction projects purpose paper identify various factors also interrelationships factors influence delays relocation utilities design methodology approach case studies conducted road bridge projects india varying levels complexity size factors causing relocation delays identified using computer aided qualitative analysis methodology cognitive mapping technique used map interrelationships factors identify critical delay factors findings factors affecting delays identified across two groups namely technical organizational factors study offers insights kinds interactions factors lead delays project critical factors causing delays identified slow response utility agencies difficulty identification underground utilities lack information underground utilities conflict agencies research limitations implications limitations study interview respondents evenly distributed among type organizations may induced bias responses impact utility relocation delays overall project delay detailed practical implications interrelationships factors potential help officials highway department contractors utility agencies others understand various interactions linkages factors contributes delays utility relocations recommendations provided practical use reduce impact delays originality value utility relocation received little attention extant literature paper seeks contribute knowledge area identifying linkages factors critical factors utility relocation delays india
drive control system modulated grating branch laser designedin order meet applications test requirements ytunable laser computer system implemented labview graphical programming language developed company hardware high speed microcontroller control core combining multiple voltage controlled current source module serial communication module realize fully programmable real time control laser drive current stability constant current source part designed module hours room temperature theadjustablecurrent source part error range bandwidth input driving signal current tuning rate reach maximum signal delay
existing programming tools writing high performance simulation code labor intensive requires sacrificing readability portability alternative prototype simulations high level language like matlab thereby sacrificing performance matlab programming model naturally describes behavior entire physical system using language linear algebra however simulations also manipulate individual geometric elements best represented using linked data structures like meshes translating linked data structures linear algebra comes significant cost programmer machine high performance implementations avoid cost rephrasing computation terms linked index data structures leaving code complicated monolithic often increasing size order magnitude article present simit new language physical simulations lets programmer view system linked data structure form hypergraph set global vectors matrices tensors depending convenient given time simit provides novel assembly construct makes conceptually easy computationally efficient move two abstractions using information provided assembly construct compiler generates efficient place computation graph demonstrate simit easy use simit program typically shorter matlab program high performance simit program running sequentially cpu performs comparably hand optimized simulations portable simit programs compiled gpus change program delivering speedups optimized cpu code
wireless sensor networks wsns widely used structural health monitoring shm attractive features low cost high efficiency flexibility optimal wireless sensor placement shm much difference traditional tethered sensors paper presents new method extract optimal wireless sensor configuration shm objective function trade linear dependence identified mode shapes connectivity wsns proposed discrete firefly algorithm dfa based basic firefly algorithm continuous variable developed solve complicated optimization problem improvements like one dimensional binary coding system hamming distance parthenogenesis movement scheme introduced make underlying concept applicable owsp numerical experiment using long span suspension bridge demonstrates dfa find optimal wireless sensor configuration high dependence identified mode shapes good connectivity wsn effectiveness proposed method validated
paper present concurrent systems class parallel programming parallel distributed computing pdc concepts taught years despite several rounds changes hardware class maintains goals allowing students learn parallel computer organizations studying parallel algorithms writing code able run parallel distributed platforms discuss benefits class reveal key elements developing class receiving funding replace outdated hardware also share activities attracting students interested pdc related topics
current medical practice long term chronic respiratory diseases treatment lacks convenient method empowering patients caregivers continuously quantitatively track intensity respiratory symptoms asthmatic wheezing occurring respiratory sounds envision mobile personalized asthma monitoring system comprising wearable energy constrained acoustic sensor smartphone paper address energy burden acquisition streaming acoustic respiratory signal lessen applying concept compressed sensing first analyse adherence normal pathologic respiratory sounds frequency representations discrete fourier transform discrete cosine transform sparse signal model given pseudo random non uniform subsampling encoder implemented msp microcontroller review tradeoffs accuracy execution time different algorithms suitable real time respiratory spectrum recovery smartphone working respiratory spectrum acquisition prototype demonstrated evaluated prototype enables real time reconstruction spectra dominated approximately eight frequency components accuracy android smartphone using orthogonal matching pursuit algorithm signal samples respect nyquist rate acquired streamed sensor
important signal source chaotic circuit play key blocks codec fields weak signal detection high speed security communication non linear control first review chaotic circuit design methodology three kinds methods like blocks stickiness blocks decreasing increasing type root cause period three implying chaos two new chaotic circuits designed demonstrated core features plus multiplier operational amplifier plus mosfet phase diagrams fft spectrums tested independent variables show new circuits chaotic greatest lyapunov exponents zero last conclusions throw birth lee circuits logic steps deep thinking precision measurements based chaos voltage current mode
article interested implementing new intelligent strategies based fuzzy controllers better integration renewable energy powerful electrical networks commonly called super grids apreliminary investigation allowed learn impact integration algebraic variables electrical network one hand modes operation power plants indeed necessary ensure strategic balance production consumption especially peak hours power operators shall ensure integration one wind farms affect aspect quality energy distributed subscribers perfect stability large power grids times integration renewable energy sources ensured use new strategies constituting potential support acts overcome hazards may hinder operation components basic grids
composite lymphoma describes rare occurrence distinct types lymphoma single anatomical location present case year old man presenting month history weakness malaise increasing dyspnea lymph node excised posterior triangle neck revealed coexistence morphologically phenotypically distinct lymphoid neoplasms consistent blastoid variant mantle cell lymphoma mcl occurring composite classical hodgkin lymphoma chl mixed cellularity subtype translocation demonstrated fluorescence situ hybridization mcl hodgkin reed sternberg cells chl multiplex polymerase chain reaction detected clonal immunoglobulin heavy chain vfr vfr vfr clonal immunoglobulin light chain kappa intron kde clonal immunoglobulin light chain lambda gene rearrangements mcl report represents first case blastoid variant mcl occurring composite chl
paper presents new improved nonlinear tracking differentiator intd hyperbolic tangent function state space system stability convergence intd thoroughly investigated proved error analysis proposed intd extract differentiation piecewise smooth nonlinear signal reach high accuracy improved tracking differentiator intd required filtering features cope nonlinearities caused noise simulations intd implemented signal derivative generator closed loop feedback control system nonlinear pid controller nonlinear mass spring damper system showed could achieve signal tracking differentiation faster minimum mean square error
efficient routing quality service qos guarantees safety traffic communication plays vital role success vehicle hoc networks vanets due connection less nature network establishing stable route connected nodes vanets extremely important challenging paper proposes new algorithm multi constrained qos routing vehicular network adopting clustering approach algorithm design qos metrics used addition stability metrics finding establishing stable route destination achieved calculating corresponding qos provision values selecting optimal reliable stable route nctuns network simulator used experiment proposed scheme results show significant improvement proposed approach terms broken links routing overhead end end delay
current terminology goals general competency framework systematically utilized education residents regardless specialty almost unrecognizable quite foreign trained example clinical professional expectations physicians training placed onto developmental framework milestones expectations required training expanded include leadership team participation skills proficiency use information technology systems based knowledge including respect resources cost care patient safety quality improvement population health sensitivity diversity individual populations patients additions physician training accreditation council graduate medical education acgme hopes remain accountable social contract medicine public focus psychiatric practice article provides general background overview major overhaul accreditation process educational goals graduate medical education briefly highlights possibilities future
modular typed dielectric barrier discharge dbd device designed tested air water remediation module made number dbd tubes arranged series parallel dbd tubes comprises inner electrode enclosed dielectric barrier arranged provide gap passage gases non thermal plasma generated gap effectively creates gaseous chemical reactions efficacy remediation gas stream containing high nox similar diesel emission wastewater containing latex presented six tubes dbd module successfully removed nitric oxide gas stream another arrangement oxygen fed two tubes dbd generate ozone treatment wastewater samples wastewater collected treatment pond rubber vulcanization pilot plant water pollution load evaluated chemical oxygen demand cod biological oxygen demand bod values preliminary results showed improvement cod treatment time increased bod results higher bod cod ratio ozonation indicate better biodegradability wastewater elsevier inc rights reserved
steep learning curve associated computer programming daunting prospect particularly well aligned way logical thinking however programming skill becoming increasingly important geography graduates entering careers atmospheric science one example particularly diverse group often require better knowledge understanding computing critically necessity field people diverse range data analysis modelling abilities article outlines module design evaluation introductory programming course non computer scientists within geography department
recent decades main demographic historical research assessed importance bio demographic components human reproduction diffusion birth control contraceptive techniques according dominant view fertility decline marital fertility mainly regulated biological physiological factors socio economic factors played limited indirect role order demonstrate importance non biological components present study focuses six pre transitional communities situated different geographic areas italy work aims demonstrate fertility levels could significantly affected social economic factors even natural fertility populations diffusion contraceptives micro level data collected several historical sources discrete time event history models applied female reproductive careers order estimate effects socio economic status household structure price fluctuations marital fertility controlling several bio demographic factors despite clear differences geographic localization environment marital reproductive behavior appeared significantly constantly affected socio economic status household composition price levels investigated communities
satellites play irreplaceable role human daily life satellites sent space time foreign space powers competing develop satellite stealth technology safety factors survival ability satellite ignored analysis space surveillance system high orbit satellite strong optical detection capability optical visibility spatial objects optical brightness typical satellite body finally pointed development satellite optical stealth technology imperative
reconstruction tridimensional geometry visual scene using binocular disparity information important issue computer vision mobile robotics formulated bayesian inference problem however computation full disparity distribution advanced bayesian model usually intractable problem proves computationally challenging even simple model paper show probabilistic hardware using distributed memory alternate representation data stochastic bitstreams solve problem high performance energy efficiency put forward way express discrete probability distributions using stochastic data representations perform bayesian fusion using representations show approach applied diparity computation evaluate system using simulated stochastic implementation discuss possible hardware implementations architectures potential sensorimotor processing robotics elsevier inc rights reserved
paper proposes application fractional order pid controller fopid reactive power compensation stability analysis stand alone micro grid enhancement voltage stability reactive compensation isolated system svc based controller incorporated paper emphasizes role fractional pid based svc controller reactive power management improved stability stand alone micro grid provides special advantage two degree freedom accurate tuning comparison conventional controller system performance particularly variations different parameters values studied properly different input parameters loading conditions improvement stability margin optimisation system parameters achieved controller based imperialist competitive algorithm elsevier ltd rights reserved
objective study examines uptake children aged predominantly years australian primary mental health service access allied psychological services programme began particular considers access use child component access allied psychological services child mental health service introduced method using routinely collected programme data national minimum dataset regional population data conducted descriptive regression analysis examine programme uptake predictors service reach consumer treatment based characteristics service results referrals children made sessions scheduled via access allied psychological services via child mental health service first years operation rate referrals children child mental health service associated rate access allied psychological services referrals consumers aged years conclusions child mental health service increased services provided within access allied psychological services programme children emotional behavioural issues families potentially filling service gap area prevention early intervention children significant levels need unable access mental health services findings policy relevant developed countries similar primary mental health care system considering means improving service access children
global prevalence obesity increasing dramatically ages although traditional causes obesity development studied widely unclear whether environmental exposure substances trace heavy metals affects obesity development among children adolescents far data national health nutrition examination survey retrieved children analyzed study urinary level nine trace heavy metals including barium cadmium cobalt cesium molybdenum lead antimony thallium tungsten analyzed association prevalence obesity among children aged years multiple logistic regression performed assess associations adjusted age race ethnicity gender urinary creatinine pir serum cotinine television video game computer usage remarkable association found barium exposure obesity children aged years negative association observed cadmium cobalt lead obesity negative associations stronger years group years group present study demonstrated barium might increase occurrence obesity cadmium cobalt lead caused weight loss among children results imply trace heavy metals may represent critical risk factors development obesity especially area state metal contamination serious
human melanopsin gene reported mediate risk seasonal affective disorder sad hypothesized caused decreased photic input winter light levels fall threshold resulting differences circadian phase sleep however unclear melanopsin increases risk sad causing differences sleep circadian phase differences symptoms mood disorder determine melanopsin sequence variations associated differences sleep wake behavior among suffering mood disorder authors tested associations melanopsin gene polymorphisms self reported sleep timing sleep onset wake time community sample non hispanic caucasian participants age yrs history psychological neurological sleep disorders authors also tested effect melanopsin variations differences preferred sleep activity timing chronotype may reflect differences circadian phase sleep homeostasis daylength day assessment measured included analyses dna samples genotyped melanopsin gene polymorphisms using fluorescence polarization genotype interacted daylength predict self reported sleep onset interaction specifically sleep onset among genotype later day individuals assessed longer days earlier day shorter days whereas individuals genotype groups show interaction effect genotype also interacted analogous way daylength predict self reported morningness interaction results suggest genotype interacts daylength predispose individuals vary sleep onset chronotype function daylength whereas genotypes seem effects vary daylength better understanding melanopsin confers heightened responsivity daylength may improve understanding broad range behavioral responses light circadian sleep mood well etiology disorders seasonal patterns recurrence exacerbation author correspondence kroeck pitt edu
nearest neighbor knn method widely used applications data mining machine learning due simple implementation distinguished performance however setting test data value previous knn methods proven make methods impractical real applications article proposes learn correlation matrix reconstruct test data points training data assign different values different test data points referred correlation matrix knn knn short classification specifically least squares loss function employed minimize reconstruction error reconstruct test data point training data points graph laplacian regularizer advocated preserve local structure data reconstruction process moreover norm regularizer norm regularizer applied learn different values different test data result low sparsity remove redundant noisy feature reconstruction process respectively besides classification tasks knn methods including proposed knn method utilized regression missing data imputation conducted sets experiments illustrating efficiency experimental results showed proposed method accurate efficient existing knn methods data mining applications classification regression missing data imputation
background cytotoxic lymphocyte antigen ctla plays pivotal role immune homeostasis dysregulated expression ctla leads many autoimmune diseases including rheumatoid arthritis systemic lupus erythematosus type diabetes controversial association ctla snp autoimmune diseases therefore meta analysis performed assess link autoimmune disease risk materials methods retrieved available studies pubmed embase february performed meta analyses included populations well ethnicity results evaluating data patients healthy controls included caucasian asian ethnicities found strongly associated autoimmune disease incidence homozygote comparison confidence interval heterozygote comparison allelic model allele allele dominant model recessive model odds ratio models suggested significant association autoimmune diseases conclusion present study indicates ctla associated susceptibility autoimmune disease hence might utilized diagnostic biomarker asian caucasian populations
colloidal behavior widely used non ionic emulsifier sorbitan monooleate span investigated non polar solvents cyclohexane xylene using electrical impedance spectroscopy eis electrical characteristics colloidal mixtures measured frequency scans ranging khz conductances low frequencies found increase increase span concentration source conductivity non polar solvents using non ionic emulsifiers usually attributed ionic impurities either span non polar solvents measured electrical characteristics pure span pure non polar solvents revealed source ionic conduction impurities span confirmed ionic impurities non polar solvents form aggregate ions ion pairs triple ions unaffected emulsifier concentration analyses using equivalent electrical circuits confirmed critical maxwell wagner frequency mixtures conductance concentration profiles mixtures showed transitions square root linear concentration dependence cmc indicated dissociation model holds cmc fluctuation model applies cmc conductance profiles enabled estimates relative hydrophilic core radius fraction charged micelles non polar solvents
article visits relationship teacher beliefs teaching behaviours analyses factors influencing translation teacher beliefs teaching behaviours using case developing generic skills university students interviews teachers skills subjects teachers specialised subjects business administration programs six different vietnamese universities shown indirect relationship teacher beliefs teaching behaviours analysis showed institutional leadership teachers personal motivation could strongly influence translation beliefs actual teaching behaviours elsevier ltd rights reserved
propose fast calculation method synthesize computer generated hologram cgh realistic deep threedimensional scene previous study proposed calculation method cgh reproducing scene called ray sampling plane rsp method light ray information scene converted wavefront wavefront numerically propagated based diffraction theory paper introduce orthographic projection rsp method accelerating calculation time numerical experiments verified accelerated calculation ratio times compared conventional rsp method calculated cgh fabricated printing system using laser lithography demonstrated deep image reconstruction mmxmm realistic appearance effect gloss translucent effect
nigeria populous country africa populous world strategic realization united nations sustainable development goals sdgs however sdg affordable clean energy goals connected reduction climate change crucial attainment sustainable development nigeria comprehensive review encompasses discussions clean energy potential obstacles stimulants clean energy implementations renewable energy policies nigeria solar biomass resources presented article huge availability nigeria nigeria potential produce estimated million tonnes oil equivalent mtoe annually biomass resources likewise billion day solar energy incident total surface nigeria biomass resources tapped renewable energy production nigeria include jatropha high oil contents sweet sorghum molasses food crops cassava rice coconut cashew millet rice oil palm maize yam agricultural residues wastes food crops cassava peels cassava liquid sludge mango peel mango seed kernel rice husks corn residues oil palm derivatives sugar cane straw bagasse forest resources municipal solid wastes animal wastes resources exploited production biogas bioethanol biodiesel briquettes organic fertilizers anaerobic digestion transesterification gasification pyrolysis briquetting also huge potentials deployment solar photovoltaic thermal systems grid grid connected hybrid installations concluded techno economic feasibility environmental significance solar power bioenergy nigeria sustainable development site specific subject factors incentives financing research development public enlightenment government policies private investments
current mode universal biquadratic filter five inputs one output employing three inverting second generation current conveyors icciis two grounded capacitors two resistors presented new circuit offers following advantage features low active passive sensitivities using grounded capacitors ideal integrated circuit implementation versatility synthesize type active filter transfer functions without requirements critical component matching conditions high output impedance needs another current follower duplicate input current signal realization notch allpass responses
going developments smart technologies wireless sensor networks micro electro mechanical systems mems computer vision fibre optics advanced data interpretation techniques may revolutionise structural health monitoring shm dedicated shm bridge assets potential produce valuable data sets provide owners managers information aid key questions current performance margins safety actual loading stress history risk fatigue extent deterioration residual life however parameters measured value data obtained differ viewed perspectives different stakeholders asset owners designers contractors researchers paper purposes monitoring reviewed methodology proposed facilitate formal discussions key stakeholders deployment specified ensure scarce resources wasted pursuit data opposed information approach used determine prima facie case specification shm project assess potential value information may obtained developed methodology trialled five historical monitoring case studies bridges authors familiar
forests represent important economic resource mountainous areas region mountain communities main form income however wood chain management contexts differs traditional schemes due limits imposed terrain morphology operation planning aspects hardware requirements fact forest organizational technical problems require wider strategic detailed level planning reach level productivity forest operation techniques applied flatlands particular perfect knowledge forest inventories improves long term management sustainability efficiency allowing better understanding forest ecosystems however knowledge usually based historical parcel information cases remote sensing information satellite imageries enough fully exploit benefit mountain areas forest stocks economic ecological value single parcel depends singletree characteristics work presented paper based results slope integrated processing control systems sustainable forest production mountain areas project investigates capability generate manage visualize detailed virtual forest models using geospatial information combining data acquired traditional field laser scanning surveys technologies new aerial survey uav systems models combined interactive virtual globes continuous assessment resource characteristics harvesting planning real time monitoring whole production
multi slice methods allow approximate phenomena without carrying full analysis skewed radial flux electrical machines idea divide machine several fem models connected electrical circuits show multi slice method perfect parallel computation computation efficiency close models modern parallel hardware results shown match computation experimental results
research violent offenders delinquent adolescents suggests endogenous testosterone concentrations strongest positive correlations violence among men low concentrations cortisol present study tested hypothesis testosterone cortisol would similarly interact determine neural activation regions supporting self regulation response anger provocation nineteen healthy asian male participants insulted asked control anger functional magnetic resonance imaging fmri cortisol levels low testosterone positively correlated activation dorsolateral prefrontal cortex dlpfc thalamus cortisol levels high induced anger control functional connectivity increased amygdala top prefrontal cortical control network moreover amygdala pfc connectivity strongest among high testosterone low cortisol research highlights possible neural mechanism testosterone cortisol may influence anger control
original realization cmos gaussian function generator presented proposed method based new approximation function able fourth order match gaussian function current mode operation circuit strongly reduces technological caused errors errors introduced temperature variations result important increasing accuracy squaring circuit represents functional core gaussian generator additionally bandwidth generator increased result current mode operation utilization new fourth order approximation function deviation ideal gaussian function smaller extended range input variable circuit designed implementing cmos technology proposed architecture compatible low voltage operation proposed gaussian function generator based new approximation function allows extend capability generating continuous mathematical functions feature obtained changing approximation function coefficients elsevier ltd rights reserved
recent evolution computer science web technology result continually expanding resources web pose unprecedented challenges big data access existing framework order access vastly increasing resource effectively clustering methods required resource description framework rdf used describe resources web results suggest linking resources semantic manner enhance searching capabilities web using keywords linking information used calculate semantic similarity consequently traditional retrieval system often suffers scalability inefficiency problems processing analyzing largescale data hence basic idea propose framework retrieves information effectively resource description framework rdf using sparql engine furthermore purpose pruning method improves accuracy quickly filtering false alarms whenever change source automatically update rdf document used semantically retrieving root source content particular resource improve scalability efficiency big data environment framework implemented hadoop widely adopted distributed computing platform
context globalwarming important understand drivers controlling river temperature order mitigate temperature increases modeling approach useful quantifying respective importance different drivers notably groundwater inputs riparian shadingwhich potentially critical reducing summer temperature study use one dimensional deterministicmodel predict summer water temperature hourly time step reach lower river france sinuous gravel bed river undergoes summer temperature increase potential impacts salmonid populations model considers heat fluxes water air interface attenuation solar radiation riparian forest groundwater inputs hydraulic characteristics river modeling performed two periods five days summers river properties obtained hydraulic modeling based cross section profiles water level surveys wemodel shadows vegetation river surface using lidar data groundwater inputs determined using airborne thermal infrared tir images hydrological data results indicate vegetation groundwater inputs canmitigate highwater temperatures summer riparian shading effect fairly similar two periods degrees degrees groundwater input cooling variable two studied periods groundwater discharge represents river discharge cools river degrees cwhile effect low degrees groundwater discharge contributes discharge effect shading varies day low morning high afternoon evening whereas induced groundwater inputs constant day overall effect riparian vegetation groundwater inputs represents water temperature diurnal amplitudes elsevier rights reserved
chulitna river bridge five girder five span steel bridge parks highway fairbanks anchorage alaska bridge built widened live load condition five support bearings contact heavily loaded trucks often travel across bridge oil fields prudhoe bay alaska virtual finite element modeling dynamic field testing ambient vibrational response structural health monitoring system used analyze evaluate monitor structural performance first stage research article presents results dynamic testing evaluation structural responses bridge dynamic field testing portable accelerometers placed centerline along bridge length record structural response ambient free decay response used evaluate dynamic properties bridge structure natural frequencies modal damping ratios identified characterized using hilbert huang transform fast fourier transform methods compared conventional approaches study demonstrates hilbert huang method found effective suitable modal parameter identification long steel girder bridge using ambient truck loading nonlinear damping first time identified based hilbert huang transform amplitude time slope modal frequencies sensitive sensor location position optimized
postmenopausal women bothersome vasomotor symptoms vms often seek alternatives hormone based treatment due medication risks personal preference sought identify effects meditation mindfulness hypnosis relaxation vms health related quality life perimenopausal postmenopausal women conducted umbrella review supplemented new randomized controlled trials rcts published since recent good quality systematic review eligible interventions searched medline cochrane database systematic reviews pubmed embase cinahl allied complementary medicine databases identified five systematic reviews six new rcts met eligibility criteria new meta analysis examining four rcts comparing paced respiration control group found paced respiration associated statistically significant decrease vms frequency standardized mean difference smd confidence interval three trials severity smd three trials sufficient new information conduct meta analyses examined effect mindfulness hypnosis outcomes interest effect vms quality life found various relaxation mindfulness interventions
introduction emergence environmental problems major social issues throughout world prompted sustainable development efforts wide range areas including industry construction transportation followed execution numerous studies policies concept sustainable development dealt earnest construction field since declaration interdependence sustainable future chicago convention uia declaration included tasks implemented respect green buildings recycling resources application energy efficient designs utilization natural energy addition application sustainable designs part green building practices countries around world implementing various green building certification standards leed gbcc casbee breeam certification standards prescribe criteria relating external environment energy conservation materials resources indoor environment energy conservation top priority issues due energy consumption building operation accounting half building life cycle cost accordingly although many studies undertaken purpose developing means conserving energy relation green buildings majority studies concentrated development technologies environmental facilities application active designs study finite nature propose hypotheses gather evidence date little suggest copying nature purports advantages architects primarily fully autonomous buildings towns yet built according described malthusian darwinian dynamic two critical questions seek address paper essence sustainable dwelling principles adhered making dwelling sustainable words study aims elucidate essence sustainability green building design implementation
medical electronic implants significantly improve people health quality life implants typically powered batteries usually finite lifetime therefore must replaced periodically using surgical procedures recently subdermal solar cells generate electricity absorbing light transmitted skin proposed sustainable electricity source power medical electronic implants bodies however results date obtained animal models apply technology human beings electrical performance characterized using human skin covering subdermal solar cells paper present electrical performance results implantable solar cell array human skin samples isolated cadavers results indicate power densities depend thickness tone human skin higher power generated thinner brighter skin generated power density high enough operate currently available medical electronic implants pacemakers require tens microwatt
objective aim study investigate predictive factors need persistent antimuscarinic therapy treatment discontinuation antimuscarinic therapy women overactive bladder syndrome oab methods consecutive oab women enrolled prospective cohort study treated solifenacin weeks university hospital factors affecting analyzed cox regression analysis results total women enrolled women underwent week solifenacin treatment dropout rate median follow period weeks interquartile range twenty seven women median free interval weeks nocturia episodes hazard ratio suboptimal response hazard ratio strong desire volume hazard ratio independent predictors cox backward stepwise regression analysis areas receiver operating characteristic curves nocturia episodes suboptimal response strong desire volume predict respectively addition normalized urinary nerve growth factor level significant hazard ratio predicting furthermore normalized urodynamic findings correlate suboptimal response changes overactive bladder symptom score urinary nerve growth factor level conclusions frequent nocturia episodes suboptimal response small bladder capacity may predict solifenacin treatment findings may serve initial guide consultation regarding treatment oab
sex hormones increasingly implicated memory formation recent literature documented relationship hormones emotional memory sex differences likely related hormones long demonstrated variety mnemonic domains including false memories hormonal contraception alters sex hormones associated bias towards gist memory away detailed memory women use emotional memory task investigated whether associated changes susceptibility false memories may related formation gist memories tested false memory susceptibility using two well validated false memory paradigms deese roediger mcdermott drm task story based misinformation task found hormonal contraceptive users less susceptible false memories compared non users misinformation task differences seen groups drm task hypothesise differences false memories misinformation task may related hormonal contraceptive users memory bias away details towards gist memory
since fda approval hiv pre exposure prophylaxis prep hiv prevention attention focused prep implementation cdc estimates million adults might benefit prep minority using prep significant unmet need increase access risk hiv given large numbers individuals indications prep enough practicing specialists meet growing need providers trained providing prep moreover since prep preventive intervention otherwise healthy individuals primary care providers pcps primary prescribers prep important clinical considerations providers take account planning prescribe prep highlighted clinical case discussed growing body research also suggests providers may cautious prescribing prep concerns regarding real world effectiveness anticipated unintended consequences associated use ambiguity prescribe review summarizes findings studies assessed prescriber behavior regarding provision prep offers recommendations optimize prep implementation primary care settings development dissemination educational interventions pcps potential prep users needed including improved methods assist clinicians identifying appropriate prep candidates programs promote medication adherence access social behavioral health services pcps well positioned prescribe prep coordinate health related services improve sexual health patients tailored educational programs needed
background exposure media violence might detrimental effects psychological adjustment associated aggression related attitudes behaviors result many media literacy programs implemented tackle major public health issue however little evidence effectiveness evaluating design effectiveness particularly regarding targeting process would prevent adverse effects improve evaluation evidence based media literacy programs objectives present research examined whether different relational lifestyles may explain different effects antiviolence intervention program research design based relational lifestyles theory authors designed randomized controlled trial applied analysis variance treatment experimental control lifestyle classes emerged data using latent class analysis communicative autonomous meta reflexive fractured subjects seven hundred thirty five italian students distributed classes participated anonymously research females measures participants completed lifestyle questionnaire well attitudes behavioral intentions dependent measures results results indicated program effective changing adolescents attitudes toward violence however behavioral intentions toward consumption violent video games moderated lifestyles communicative relational lifestyles showed fewer intentions consume violent video games boomerang effect found among participants problematic lifestyles conclusion adolescents lifestyles played important role influencing effectiveness intervention aimed changing behavioral intentions toward consumption violent video games reason audience lifestyle segmentation analysis considered essential technique designing evaluating improving media literacy programs
inherited heart disease causing electric instability heart suggested risk factor sudden unexpected death epilepsy sudep purpose study reveal correlation epilepsy related sudden unexpected death sud inherited heart disease twelve epilepsy related sud cases seven males five females aged years examined nine cases fulfilled criteria sudep three cases died drowning addition examining three major epilepsy related genes used next generation sequencing ngs examine inherited heart disease related genes detected known pathogenic variants rare variants minor allele frequencies pathogenicity variants evaluated graded eight silico predictive algorithms six known six potential rare variants detected among three known variants ldb dsc kcne three potential rare variants myh dsp dsg predicted silico analysis possibly highly pathogenic three nine sudep cases two three cases desmosome related variants showed mild possible significant right ventricular dysplasia like pathology case ldb myh variants showed hypertrabeculation left ventricle severe fibrosis cardiac conduction system three drowning death cases one case mild prolonged interval two variants ank study shows inherited heart disease may significant risk factor sud epilepsy cases even pathological findings heart progressed advanced stage disease combination detailed pathological examination heart gene analysis using ngs may useful evaluating arrhythmogenic potential epilepsy related sud
term emotional dysregulation refers impaired ability regulate unwanted emotional states scientific evidence supports idea emotional dysregulation underlies several psychological disorders example personality disorders bipolar disorder type interpersonal trauma anxiety disorders mood disorders post traumatic stress disorder emotional dysregulation may derive early interpersonal traumas childhood early traumatic events create persistent sensitization central nervous system relation early life stressing events reason authors suggest common endophenotypical origin across psychopathologies last years cognitive behavioral therapy increasingly adopted interactive ontogenetic view explain development disorders associated emotional dysregulation unfortunately standard cognitive behavior therapy cbt methods useful treating emotional dysregulation cbt derived new approach called schema therapy integrates theory techniques psychodynamic emotion focused therapy holds promise fill gap cognitive literature model psychopathology viewed interaction innate temperament child early experiences deprivation frustration subject basic needs deprivation may lead develop early maladaptive schemas ems maladaptive modes present paper point emss modes associated either dysregulated emotions dysregulatory strategies produce maintain problematic emotional responses thanks special focus therapeutic relationship emotion focused experiential techniques approach successfully treats severe emotional dysregulation paper make several comparisons main ideas science emotion regulation present conceptualize pathological phenomena terms failed regulation strategies techniques foster successful regulation patients
background descriptive epidemiologic studies injury soccer community level players although many sports injury surveillance systems described scientific literature implemented community level soccer restricted adolescent players single club purpose objective study develop method undertaking routine surveillance injury community level soccer study design cohort study level evidence methods cohort community level players aged years followed winter competitive season week player contacted telephone interview conducted collect data participation matches training sessions injuries adherence injury prevention measures results seventy five percent cohort male median age years data collected player matches totaling player match hours player training sessions totaling player training hours total match injury events reported giving overall incidence rates injury events per player match hours injury events per player matches incidence rate match injury events significantly higher females males total training injury events reported giving overall incidence rates injury events per player training hours injury events per player training sessions common injuries sprains strains lower limb tackling common cause injury conclusion study shown routine injury surveillance using cohort design exposure measurement successfully implemented community level soccer
urban green space forms integral part urban ecosystems quantifying urban green space substantial importance urban planning development considering drawbacks previous urban green space index models established either grid method green distribution difficulty validation process earlier urban green space index models study exploits advantages multisource high resolution remote sensing data establish building neighborhood green index bngi model model analyzes spatial configuration built areas vegetation based building oriented method considers four parameters green index proximity green building sparsity building height comparing bngi different types characteristic building regions found bngi evaluates urban green space sensitively also found high rise low sparsity area lower mean value bngi compared low rise low sparsity neighborhood whereas mean equal neighborhoods taking characteristics urban building green types consideration bngi model effectively used many fields land suitability analysis urban planning
background development measures monitor evaluate performance quality emergency medical services ems systems focus attention many years medicare rural hospital flexibility program flex program established congress provides grants states implement initiatives strengthen rural healthcare delivery systems including better integration ems systems care objective building national efforts develop ems performance measures sought identify measures relevant rural communities hospitals supported flex program measures intended use monitoring rural ems performance community level well use state flex programs federal office rural health policy forhp demonstrate impact flex program methods evaluate performance ems rural communities conducted literature search reviewed research performance measures conducted key ems organizations recruited panel ems experts identify rate rurally relevant ems performance measures well emergent protocols episodes trauma elevation myocardial infarction stemi stroke rated measures assessed inclusion final measure set results expert panel identified program performance measures support ems services rural communities measures monitor capacity local agencies collect report quality financial data use data improve agency performance train rural ems employees emergent protocols age groups conclusion system care approach rural ems measures set based support forhp goal better focusing state flex program activity improve program impact performance rural ems services areas financial viability quality improvement local regional health system performance
strawberry one economically important fruit crops world cytokinins cks play critical role plant growth development well stress response level cks plants regulated synthesis degradation pathways key synthetic enzymes cks isopentenyl transferases ipts lonely guys logs surveyed strawberry genome identified seven fvipt genes nine fvlog genes analyzed gene structures conserved domains phylogenetic relationships rice arabidopsis isoelectric points glycosylation sites proteins predicted also analyzed tissue organ specific expression patterns fvipt fvlog genes fvipt fvlog genes showed different expression profiles different organs fvipt fvlog genes regulated response osmotic stress high temperature treatment exogenous abscisic acid aba application suggesting possible roles genes plants resistance abiotic stresses addition found results bioinformatics analyses identify cis regulatory elements may consistent experimental expression data thus computer predicted putative cis elements need confirmed experiments systematic analyses fvipt fvlog families provide foundation characterizing function genes regulation growth development stress tolerance fragaria vesca well reference improving stress tolerance manipulating content
study design systematic review meta analysis background remains unclear whether exercise combining different types physical activities combined exercise interventions would effectively preserve postmenopausal women bone mineral density bmd different sites objective examine impact combined exercise interventions lumbar spine femoral neck total hip total body bmd postmenopausal women methods electronic database search conducted pubmed embase sportdiscus web science january randomized controlled trials conducted combined exercise interventions reported bmd values postmenopausal women included two authors independently extracted data individual studies primary end point change bmd values baseline follow effect sizes estimated standardized mean difference smd methods using fixed effects models results eleven randomized controlled trials including postmenopausal women met inclusion criteria levels study heterogeneity relatively low exercise integrating different physical activities significantly increased lumbar spine smd confidence interval femoral neck smd total hip smd total body smd bmd combined exercise interventions generated beneficial effect femoral neck bmd smd groups women aged younger years significantly improved lumbar spine bmd smd groups women aged years older conclusion findings suggest combined exercise interventions appear effective preserving postmenopausal women bmd lumbar spine femoral neck total hip total body
women bone mass undergoes changes pregnancy postpartum period risk subsequent development osteoporosis thus present study aims evaluate effects flaxseed flour femur quality post weaning dam rats weaning rats divided control experimental groups treated diet containing flaxseed flour lactating period maintenance period days post partum serum hormone fatty acids composition bone compartments computed tomography biomechanical analyses determined food intake length body mass hormone analysis total bone compartments showed similar results biomechanical computed tomography analysis fatty acids composition group showed higher maximum force breaking strength rigidity femoral head radiodensity presented lower total polyunsaturated fatty acids arachidonic acid higher ala epa fatty acids composition flaxseed flour well protein profile calcium content able improve bone quality may associated lower serum levels arachidonic acid higher epa showing anti inflammatory profile increased deposition organic matrix post weaning period may result prevention future osteoporosis
coupling iso thio cyanates amines alcohols thiols yield thio urea urethane gas phase important vacuum deposition processes functional organic thin films molecular layer deposition chemical vapor deposition study kinetics thermodynamics reactions bifunctional reactants containing nco ncs moieties calculated using double hybrid density functional theory find systematic structure reactivity relationships activation energy proton transfer step correlated basicity nucleophile bronsted acid reactants exothermicity coupling reaction depends whether functionality nco ncs analysis transition states revealed location transition state affected basicity reactants vibrational electronic spectra product obtained help future experimental investigations
providing adaptive support users engaged learning tasks central focus intelligent tutoring systems evidence female male users may benefit differently adaptive support yet understood effectively adapt task support gender paper reports study four versions intelligent tutoring system introductory computer programming offering different levels cognitive conceptual problem solving affective motivational engagement support results show female users reported significantly engagement less frustration affective support system versions human tutorial dialogue condition used comparison consistent difference observed females males results suggest presence mars venus effect systematic difference female male users benefit cognitive affective adaptive support findings point toward design principles guide development gender adaptive intelligent tutoring systems
present year old boy cerebral palsy intellectual disability speech delay seizures carries likely pathogenic novo heterozygous deletion microdeletion syndrome region also carries maternally inherited duplication impacting first three exons chrna majority previously published cases syndrome shared common features including growth restriction muscular hypotonia absent severely delayed speech using copy number variation cnv data available subjects defined minimal critical region within syndromic region encompassing hnrnpd also identified larger critical region encompassing ten protein coding genes six prkg rasgefb hnrnpdl hnrnpd lin cops significantly low number truncating loss function mutations long range chromatin interaction data suggest deletion may alter chromatin interactions microdeletion region suggest deletion misregulation genes likely contribute neurodevelopmental neuromuscular abnormalities syndrome
nonlinear evolution equations form fundamental theme mathematical physics search exact solutions nonlinear equations interest recent years paper obtain exact solutions nonlinear jaulent miodek hierarchy dimensional calogero bogoyavlenskii schiff equation using generalized kudryashov method calculations study made checked back aid maple packet program
objective unusual unexpected effect treatment background ankylosing spondylitis chronic inflammatory disease predominantly affects axial skeleton ability anti tnf alpha agents reduce disease activity patients axial spondyloarthritis axspa including demonstrated multiple randomized trials several meta analyses reports efficacy rituximab treatment described good results report patient failed anti tnf therapy showed good clinical improvement rituximab therapy case report year old male patient diagnosed showed poor response sulfasalazine non steroidal anti inflammatory drugs nsaids infliximab initiated marked improvement per bath ankylosing spondylitis disease activity index basdai due disease flare patient switched etanercept subsequently acquired papillary thyroid cancer etanercept discontinued underwent total thyroidectomy followed radioiodine therapy ongoing active disease nsaids sulfasalazine resumed lack response basdai rituximab started resulted significant improvement basdai conclusions rituximab potential target therapy patients start lose response tnf inhibitors develop solid malignancies placebo controlled studies required
traditionally sport heteronormative domain space women men different sexual orientations rejected transgressing questioning heteronormative patriarchy recent years spanish society seems changed tolerant respectful climate diversity created however current studies analysing situation sport spain work attitude scale towards sexual diversity sport presented initial version item questionnaire completed athletes genders whose ages ranged years old validity content initial battery items analysed four experts afterwards two successive exploratory factor analyses carried assess internal validity determining scale items adequate internal consistency reliability alpha results also show four factors bring attitudes together cognitive attitudes towards diversity attitudes towards gender stereotypes attitudes towards transgression affective attitudes towards diversity item analysis analysis internal consistency four factors also carried therefore study results support conclusion scale general shows good adaptation due validity reliability
paper presents results experimental model study transient loading steam generator tubes postulated main steam line break mslb accident nuclear power plant problem involves complex transient two phase flow dynamics fluid structural loading processes better understanding phenomenon permit development improved design tools ensure steam generator tube integrity pressure temperature measured upstream downstream sectional model tube bundle cross flow transient tube loads directly measured using dynamic piezoelectric load cells high speed videos taken observe better understand flow phenomena causing tube loading working fluid tube bundle normal triangular array pitch ratio flow bundle choked majority transient transient tube loading explained terms associated fluid mechanics empirical model developed enables prediction maximum tube loads pressure drop known
explore favorable structural system cable stayed bridges ultra kilometer main span based fully self anchored cable stayed bridge main span partially earth anchored cable stayed bridge scheme main span designed numerical investigation dynamic characteristics aerostatic aerodynamic stability two bridge schemes conducted results compared suspension bridge similar main span considering aspect wind stability feasibility using partially earth anchored cable stayed bridge super long span bridges ultra kilometer main span discussed moreover effects structural design parameters including length earth anchored girder number auxiliary piers side span height width girder tower height etc dynamic characteristics aerostatic aerodynamic stability partially earth anchored cable stayed bridge analyzed reasonable values proposed results show compared fully self anchored cable stayed bridge suspension bridge similar main span partially earth anchored cable stayed bridge greater structural stiffness better aerostatic aerodynamic stability consequently becomes favorable structural system super long span bridges ultra kilometer main span partially earth anchored cable stayed bridge achieve greater stiffness better wind stability cases increasing earth anchored girder length increasing height width girder setting several auxiliary piers side span increasing tower height
brain metastasis common carries poor prognosis melanoma single institution retrospective cohort melanoma patients analyzed determine braf mutational status associated brain metastasis eighty three patients braf mutations initial diagnosis braf mutations associated younger age higher proportion females higher ajcc stage regional lymph node involvement family history cancer compared braf braf patients increased risk brain metastasis multivariate analysis however braf patients treated selective braf inhibitor brafi similar risk brain metastasis compared braf patients moreover treatment brafi significantly prolonged time initial diagnosis brain metastasis diagnosis compared tissues brain frequent site metastasis braf patients without brafi frequency brain metastasis lower braf braf patients brafi respectively proportion patients brain metastasis site braf braf without brafi braf brafi groups respectively study provides evidence clinical importance braf mutations braf inhibition progression melanoma brain metastasis new melanoma spreads brain usually kills patient inside year metastases predicted stopped become lethal authors investigated whether mutation braf gene increases chances brain metastasis cohort melanoma patients showed carrying mutation braf developed brain metastases often normal copies gene patients braf mutation received treatment braf inhibitor however effect reversed patients experienced risk without braf mutations
considerable interest relationship biodiversity disease recently captured attention research community important public policy implications particular malaria amazon region often cited example forest conservation improve public health outcomes however despite growing body literature increased understanding relationship malaria land use land cover change lulc amazonia contradictions emerged studies report deforestation increases malaria risk others claim opposite assessing malaria risk requires examination dynamic processes among three main components environment lulc landscape transformations vector biology mosquito species distributions vector activity life cycle plasmodium infection rates iii human populations forest related activity host susceptibility movement patterns paper conduct systematic literature review malaria risk deforestation amazon focusing three components explore key features likely generate contrasting results using reviewed articles data brazil peru conclude suggestions productive avenues future research article part themed issue conservation biodiversity infectious disease scientific evidence policy implications
mutations jak mpl calr genes identified majority myeloproliferative neoplasm mpn patients patients negative three mutations called triple negative mpn study examined mutational profiles triple negative mpn patients including essential thrombocythemia primary myelofibrosis polycythemia vera targeted next generation sequencing performed using actonco comprehensive cancer panel ion ampliseq comprehensive cancer panel life technologies target coding exons cancer related genes overall nonsynonymous somatic mutations detected patients range mutations per sample notably one patient found jakvf kitpl mutations low allele frequency one mplpl mplmt mutations identified respectively recurrent mutations also identified including kmtc kmtd irs syne pdedip setd atm tnfaip ccnd addition germline mutations also found cancer related genes copy number changes rare cohort mpns conclusion somatic germline mutations detected mpn patients
zernike moments zms useful image descriptors belong family orthogonal rotation invariant moments due many attractive characteristics used many pattern recognition image processing computer vision applications however suffer high computation complexity prohibits use many practical problems zms computed convolution process image data zernike kernel functions past various attempts made efficient computation zms considerable success achieved using recursive relations way symmetry anti symmetry zernike function paper propose new computational flow model convolution image data zernike kernel functions proposed model also takes advantage way symmetry anti symmetry property kernel function builds convolution process reduces number additions subtractions number multiplications refer table text location octant circular disk moments computed detailed experimental results show speed zms computation increases factor varying depending upon order moments multiple images compared existing fast algorithms available literature zms computed pixel image overlapping blocks improvement computation time varies elsevier gmbh rights reserved
study market framework proposed practical implementation lossy financial transmission rights ftrs advantage lossy ftrs conventional ftrs lossy ftrs settled directly according locational marginal prices lmps without requiring lmp decomposition therefore price risk forward contract perfectly hedged power transaction involved perfectly matches corresponding ftr although proposed long back lossy ftrs still find entry market prejudice market complexity inefficiency principal aim study thus create necessary environment make fine risk hedging tools available market first suitable format forward contracts prescribed enable proper utilisation lossy ftrs detailed lossy ftr auction model prepared based upon suitable optimal power flow opf formulation addition implementation lossy ftrs shown system appropriately modelling line power flow behaviour according chosen opf framework lossy ftr auction model prepared thoroughly verified ftr issuance per market expectations
work comprehensive characterization sponge like nanostructured zinc oxide films proposed marked attention exhibited sensing properties sponge like zinc oxide films grown different kinds hard flexible substrates two step process involving room temperature sputtering deposition metallic sponge like zinc films followed low temperature oxidation treatment method allowed growing films thickness micrometers material presented polycrystalline porous structure randomly oriented grains formation top electrodes sensing properties samples assessed particular films exhibited sensing capability photocurrents four orders magnitude higher current values measured dark conditions material also showed considerable piezoelectric response mechanical stimulus exerted impact water drop delivered surface generated intense piezoelectric output voltage peaks thus proving material sensing capability maximum average output power density calculated interesting properties make sponge like zno promising smart material sensing energy harvesting applications elsevier ltd rights reserved
paper deals combined additive subtractive process metal parts production starting configuration commercial lom machines new machine design proposed metal parts equipped atc various form tools capable adaptive slicing attention focused adaptive slicing algorithm advantages proposed solution application comparison existing solutions improved aesthetic appearance part also new methodology final form would result faster product better accuracy
finding alternative resources secure increase water availability key issue urban areas makes research alternative local water resources increasing importance context political tension main water provider malaysia singapore implementing comprehensive water policy decades relies water demand management local water resource mobilisation order reach water self sufficiency production water alternative resources seawater desalination water reclamation implies energy consumptive technologies reverse osmosis context increasing energy costs high primary energy dependency water self sufficiency objective likely important challenge singapore aim paper quantify long term impact singapore water policy national electricity bill investigate impact singapore projects reduce water energy footprint estimate singaporean electricity demand already dedicated water wastewater treatment processes water energy footprint dramatically increases coming decades ambitious research projects may buffer energy cost water self sufficiency
important insights role interfacial composition structure controlling digestion oil water emulsions gained last decade driving interest relies necessity controlling digestion lipids decrease delay fat intake address obesity crisis existing worldwide assuring bioaccessibility bioactive emulsified lipids hydrophobic bioactive compounds article mainly reviews relationship composition structure protein polysaccharides stabilized emulsions susceptibility vitro lipolysis analysis concentrates emulsions proteins polysaccharides used single emulsifiers emulsions stabilized protein polysaccharide conjugates protein polysaccharide multilayer emulsions primary emulsion formed protein protein polysaccharide emulsions proteins main emulsifiers polysaccharides perform stabilizers mechanisms involved control rate extent lipolysis discussed special attention given interactions emulsions components bile salts critical point controlling lipids digestion elsevier ltd rights reserved
goal invited editorial introduce ieee rita special issue trends computers education special issue integrates thoroughly revised extended versions five outstanding papers presented international symposium computers education siie held rioja november
decisions made early design phase enormously contribute performance product life cycle since users preferences may change time product design revised preference change providing accurate data designers ensures optimal decision product design research presents new method assess effects quantified changes product cost development time addition two models optimize design unexpected disturbances proposed normally optimal parameters require several search iterations design process finalizing product design time terms number iterations reduced adding resources iteration using modern control engineering methods however adding resources increase design cost proposed method research minimizes total product design cost environmental impacts changes users preferences method validated using example smartphone design research novelty method applying quantified changes external disturbances changes users preferences design process addressing real problem industry proposing optimal models products reduced cost environmental impacts
various additives including food colorants fcs used food industry make food appealing consumers add variety despite widespread usage fcs adverse reactions related consumption including reactions triggered immune immediate delayed type hypersensitivity non immune intolerance mechanisms considered rare discrepancy perception patients parents reported prevalence adverse reactions additives higher atopic individuals documented reactions mild involving mainly skin rarely anaphylaxis major problem diagnosing reactions fcs identification offending agent based careful dietary history taking allergy testing usually unrevealing except reaction natural colorants treatment consists avoidance offending colorant successful desensitization procedures reported crown copyright published elsevier ltd rights reserved
modern computer graphics capable generating highly photorealistic images although considered success computer graphics community given rise complex forensic legal issues compelling example comes need distinguish computer generated photographic images pertains legality prosecution child pornography united states performed psychophysical experiments determine accuracy observers capable distinguishing computer generated photographic images find observers considerable difficulty performing task difficulty observed years ago computer generated imagery photorealistic also find observers likely report image photographic rather computer generated resolution surprisingly little effect performance finally find small amount training greatly improves accuracy
many areas world leaching phosphorus soil causes serious water pollution purpose research decrease phosphorus loss soil adsorption behavior biochars special structural characteristics study series analysis methods including scanning electron microscopy infrared spectroscopy elemental composition thermogravimetric ray diffractometer analysis used investigate properties structures different sources biochars adsorption phosphorus maize straw biochar rice hull biochar pine biochar quantified balance method research results show pine biochar structural thermal stability maize straw biochar rice hull biochar different sources biochar significantly different phosphate adsorption capabilities pine biochar best phosphorus adsorption capacity actual maximum adsorption capacity mgg however phosphorus adsorption capacity maize straw biochar minimum actual maximum adsorption capacity mgg volume phosphorus adsorption biochars increases increasing concentration phosphorus added solution rate increase gradually decreases phosphorus adsorption curve agreed well langmuir isotherm equation
paper presents software suitable undergraduate students implement computer programs compose music software offers low floor students easily get started also high ceiling complex compositional theories modelled students particularly interested tonal music aesthetic preferences supported without stylistically restricting users software use rule based approach constraint programming allow great flexibility software cluster rules implements collection compositional rules rhythm harmony melody counterpoint new music constraint system cluster engine orjan sandred software offers low floor observing several guidelines programming environment uses visual programming cluster rules cluster engine extend algorithmic composition system pwgl music theory definitions follow template students learn examples create definitions finally students offered collection predefined rules freely combine definitions music technology students including students without prior computer programming experience successfully used software students used musical results computer programs create original compositions software also interesting postgraduate students composers researchers complex polyphonic constraint problems supported high ceiling users freely define rules combine predefined rules also cluster engine efficient search algorithm makes advanced problems solvable practice
background major index used evaluate improvements brain function although studies reported evaluating effectiveness manual acupuncture electro acupuncture monitoring research field yet active aim study investigate effects periodic low frequency electrical stimulation applied brain activity analyzing method study conducted randomized double blind test subjects including males females subject received sessions stimulation one month period session low frequency electrical stimulation average applied acupuncture points event related potentials erps measured first session last session electrical stimulation results results chi square test indicated double blind test conducted correctly compared sham group subjects real stimulation group showed tendency toward decreasing latency increasing amplitude sessions stimulation women amplitude significantly increased fcz cpz conclusions experiment low frequency electrical stimulation two acupuncture points confirmed positive influence prevention natural cerebral aging
cancer common event patients rheumatic diseases cases disease risk factors treatment could play role favoring cancer article analyzes current knowledge risk malignancy associated biologics rheumatic diseases discusses methodological issues considered evaluating association disease treatments risk cancer article focuses risk overall malignancy also skin cancer lymphoma recurrent cancer associated biologics marketed treatment rheumatic diseases
work address several theoretical computational issues related thermomechanical modeling shape memory alloy materials specifically paper revisit non isothermal version theory large deformation generalized plasticity suitable describing multiple complex mechanisms occurring materials phase transformations also discuss computational implementation generalized plasticity based constitutive model demonstrate ability theory simulating basic patterns experimentally observed behavior set representative numerical examples
fitting geometric algebraic surfaces data pervasive problem many fields science engineering particular ellipsoids employed features computer graphics sensor calibrations also useful pattern recognition computer vision body detection electronic device design standard ellipsoid fitting techniques solve problem involve minimization squared errors however procedures sensitive noise propose method based minimization absolute errors although algorithm iterative adaptive step size used achieve faster convergence leads substantial improvement robustness outlier data proposal demonstrated several computational examples comprise synthetic data real data scanner stereo camera
work concerns behavior inflatable beams subjected bending loads authors worked subject strength materials theories written paper first propose calculate precisely radius length inflated tubes needed use strength materials theory case high pressure usual linear equations precise enough needed use non linear set equations second part focuses strength materials theory assumptions straight section remains plane deformation first considered shear bending stiffnesses identified use results code dedicated inflatable structures takes account orthotropic behavior fabrics finally correction moduli proposed correction takes account variation geometry natural state corresponds non inflated beam initial state corresponds inflated beam
free living flatworm genus macrostomum emerging model system studying links sex allocation sexual selection mating system evolution well underlying developmental physiological mechanisms responsible wide intra inter specific variability reproductive phenotypes despite compelling comparative morphological evidence sexual diversity detailed experimental work reproductive behaviour physiology macrostomum far largely limited two species lignano hystrix obligate preferential outcrosser respectively study establish third species pusillum exhibits combination reproductive traits strikingly different congeners unlike lignano demonstrate pusillum adjust sex allocation speed spermatogenesis prevailing social group size macrostomum pusillum relatively simple sperm morphology likely explains short spermatogenesis duration report linked hypodermically inseminating mode fertilization show also means worms capable self fertilization surprisingly unlike hystrix selfing isolated worms commences short delay compared onset reproduction grouped individuals little evidence differential inbreeding depression isolated progeny combined results suggest nature pusillum may regularly selfing contrast congeners studied date findings highlight rapid correlated evolution reproductive traits reinforce utility genus macrostomum understanding evolutionary developmental mechanisms responsible diversity
crowd simulation studied extensively computer graphics animation safety real time crowd simulator developed based potential fields agent approach article simulator produces realistic complex heterogeneous motion improves simulation rates least comparison potential field results model simulator efficiently tackle problems global optimal navigation collision avoidance dynamic interaction furthermore allows agent make independent decisions
mental health problems parental anxiety children epilepsy investigated parents children epilepsy healthy children asked complete strengths difficulties questionnaire children state trait anxiety inventory epilepsy girls boys mean age years control group successful school emotional problems score children epilepsy higher control group case group behavior problems attention deficit hyperactivity scores higher respectively prosocial behavior scores control group significantly higher state trait anxiety levels parents children epilepsy higher children epilepsy neuro behavioral problems parents greater anxiety levels physicians contact children epilepsy psychological health family besides seizure control
traditional nutrition research dealt providing nutrients nourish populations nowadays focuses improving health individuals diet modem nutritional research aiming health promotion disease prevention performance improvement consequence ambitious objectives disciplines nutrigenetics nutrigenomics evolved nutri genetics asks question individual genetic disposition manifesting single nucleotide polymorphisms copy number polymorphisms epigenetic phenomena affects susceptibility diet nutrigenomics addresses inverse relationship diet influences gene transcription protein expression metabolism major methodological challenge first pre requisite nutrigenomics integrating genomics gene analysis transcriptomics gene expression analysis proteomics protein expression analysis metabonomics metabolite profiling define healthy phenotype long term deliverable nutrigenomics personalised nutrition maintenance individual health prevention disease transcriptomics serves put proteomic metabolomic markers larger biological perspective suitable first round discovery regulatory networks metabonomics diagnostic tool metabolic classification individuals great asset platform quantitative non invasive analysis easily accessible human body fluids like urine blood saliva feature also holds true extent proteomics constraint proteomics complex terms absolute number chemical properties dynamic range compounds present apart addressing complex ome proteomics represents platform delivers markers disposition efficacy also targets intervention omics disciplines applied context nutrition health potential deliver biomarkers health comfort reveal early indicators disease disposition assist differentiating dietary responders non responders last least discover bioactive beneficial food components paper reviews state art three omics platforms discusses implication nutrigenomics elaborates applications nutrition health digestive health allergy diabetes obesity nutritional intervention nutrient bioavailability proteomic developments applications potential field nutrition specifically addressed another review issued group
paper single stage multi path operational transconductance amplifier ota fast settling response high performance applications designed produced amplifier uses current shunt technique double recycling structure cross coupled positive feedback configuration idle devices signal path enhance transconductance conventional folded cascode amplifier transconductance boosting techniques lead higher gain gain bandwidth gbw slew rate lower settling time compared previous structures phase margin degraded simulation results presented using cmos technology show increment gbw gain improvement approximately power consumption compared conventional amplifier
chronic pain global problem reached epidemic proportions estimated adults suffer pain another diagnosed chronic pain year goldberg mcgee despite high prevalence chronic pain estimated billion people afflicted worldwide much remains understood underlying causes condition urgent requirement better pain therapies discovery novel targets development better analgesics rely assortment preclinical animal models however major challenges translating discoveries made animal models realized pain therapies humans review discusses common animal models used recapitulate clinical chronic pain conditions neuropathic inflammatory visceral pain methods assessing sensory affective components pain animals also discuss advantages limitations modeling chronic pain animals well highlighting strategies improving predictive validity preclinical pain studies wiley periodicals inc
aimsto compare efficacy safety two commercially available single incision slings sis trans obturator vaginal tapes tot namely miniarc monarc slings report results year follow methodsa retrospective observational study prospectively collected data conducted women primary stress urinary incontinence sui single tertiary referral center patients treated miniarc monarc compared data regarding intraoperative post operative outcomes collected compared kaplan meier analyses assessed continence rate objective cure rate novo overactive bladder symptoms oab surgical failure erosion free rates year follow log rank test used compare efficacy complication patients stratified according type surgery resultsmedian follow months patients treated monarc slings miniarc two groups homogeneous terms pre operative characteristics year follow difference found monarc miniarc patients monarc showed better oab free rates significant differences found terms erosion rates results limited retrospective nature conclusionswe demonstrated short term results miniarc maintained time defining comparability two slings years terms subjective objective outcomes complications neurourol urodynam wiley periodicals inc
catechol methyltransferase comt genotype implicated vulnerability factor several psychiatric diseases well aggressive behavior either directly interaction adverse environment present study aimed investigating susceptibility properties comt genotype adverse favorable environment relation physical verbal aggressive behavior comt valmet polymorphism genotyped swedish population based cohort including individuals ages years males significant three way interaction found correction multiple testing comt genotype exposure violence parent child relationship association physical verbal aggressive behavior homozygous val allele reported lower levels physical aggressive behavior exposed violence time experienced positive parent child relationship compared met carriers thus susceptibility properties comt genotype observed relation physical aggressive behavior supporting hypothesis comt genotypes modifying sensitivity environment confers either risk protection aggressive behavior novel findings warrant investigation replication independent samples wiley periodicals inc
background autistic individuals commonly show circumscribed special interests areas obsessive interest specific category present study investigated impact interests attention aspect autistic cognition often reported altered neurotypical individuals interest expertise shown result automatic attentional priority related items examine whether change salience also seen autism methods adolescents young adults without autism performed personalized selective attention task assessing level attentional priority afforded images related participant specific interests addition participants performed similar task generic images order isolate effects interest expertise crucially autistic non autistic individuals recruited study held strong passion interest differences attention could solely attributed differing prevalence interests two groups tasks participants asked perform central target detection task ignoring irrelevant distractors related unrelated interests level distractor interference various task conditions taken indication attentional priority results neurotypical individuals showed predicted attentional priority circumscribed interest images generic items reflecting impact interest expertise contrary predictions autistic individuals show priority processing interest related stimuli task demands low attention images unrelated circumscribed interests equivalent two groups conclusions results suggest despite autistic individuals holding intense interest particular class stimuli may reduced impact prior experience expertise attentional processing implications absence automatic priority discussed terms behaviors associated condition
due increase unstructured data companies shifting towards nosql still data perfectly relational till date modeling various software functionality efficiently done using relational databases storing different parts data sql nosql cumbersome requires lot manual work manage multiple data sources hence theoretical framework discussed bridge gap two technology abstraction layer
paper adapt robust quantization index modulation qim originally proposed chen wornell images protection relational databases order embed bit watermark modulate relative angular position circular histogram center mass one numerical attribute experimentally verify suitability scheme terms distortion robustness complexity within framework one medical database one half million inpatient hospital stay records solution robust common database attacks tuple deletion insertion attribute value modifications embedded message error free retrieved even suppression addition database tuples making suitable database copyright protection owner identification traitor tracing
curious eroded depressions resembling eye shedding elongate tear found gently sloping intertidal carbonate rich arenite outcropping sea coast near lakes entrance victoria southeast australia depressions known locally tears virgin evidently formed multiple generations barnacle chthamalus antennatus darwin association cyanobacteria round part depression offers barnacle modicum protection impacts high tides also partially inhabited cyanobacteria extend tend fill elongate tear appears first case mutualism higher invertebrate cyanobacteria cyanobacteria reducing barnacle risk desiccation receiving metabolic wastes low tides also first record balanomorph barnacle eroding calcareous arenite beneath shell net effect would expected reduce adhesion substrate however siliceous residue resulting barnacle dissolution calcite rich sedimentary rock sequestered delicate folds inside shell wall grows brief review cirripedes capable excavation includes first photographic documentation excavation mollusc shell verrucomorph
salmon gelatin boldine natural antioxidant used prepare edible films cold casting method concentration component optimised applying box behnken experimental design bbd goal maximising radical scavenging capacity film forming suspensions ffs measured dipheny picrylhydrazyl dpph free radical assay results showed synergistic effect gelatin boldine antioxidant capacity radical scavenging antimicrobial activity gelatin escherichia coli atcc listeria monocytogenes isp release boldine food simulant faster films containing gelatin containing kinetic data boldine release films fitted weibull model possible molecular interactions gelatin boldine observed ftir spectrum composite films within range strong interference caused boldine hydrogen bonding water imide residues observed owing simultaneous antioxidant antimicrobial activities displayed gelatinboldine films potential application preservation perishable fresh food fish meat cheese elsevier ltd rights reserved
previous studies suggested real time person perception relies continuous competition partially active categories smoothly compete time two studies demonstrated involvement different kind competition study participants selected correct sex category morphed faces mouse trajectories often exhibited continuous attraction toward incorrect category increased sex category ambiguity indicating continuous competition trials however trajectories initially pursued incorrect category abruptly redirected toward correct category suggesting early incorrect category activation rapidly reversed later processing abrupt category reversals also increased ambiguity study participants presented faces containing sex typical sex atypical hair cue context norm either sex typical targets normative context sex atypical targets counternormative context sex atypical targets induced greater competition normative context sex typical targets induced greater competition counternormative context together results demonstrate categorizing others involves smooth competition abrupt category shifts flexibly adapt social context
hydrogen bond based visible light response heterojunction photocatalyst melam fabricated first time facile planetary milling treatment fourier transform infrared spectroscopy ftir thermogravimetric analysis reveal formation hydrogen bonds center dot center dot center dot melam compared complete decomposes acetaldehyde also shows times times higher photocatalytic activity photo degradation propanol photo generation respectively visible light irradiation ray photoelectron spectroscopy suggests potential difference center dot center dot center dot heterojunction provides driving force charge transfer melam furthermore hydrogen bonds offer ultrafast electron pathway heterojunction study demonstrates hydrogen bond based heterojunction could promising approach developing new photocatalyst efficient visible light photocatalytic activity elsevier rights reserved
paper presents thermo economic analysis based data real smart polygeneration microgrid spm designed satisfy energy demands university campus savona italy plant made different cogenerative generators micro gas turbines internal combustion engine renewable generators two auxiliary boilers one time generators distributed around campus coupled electrical thermal storages since several cogenerative units included grid integration different storage systems relevant order determine best management strategy following thermal electrical requests taking proper account strong difference two energy demand profiles thermo economic analysis performed exploiting software ecomp developed authors research group order find best operational strategy considering importance appropriate storage system manage polygenerative energy district attention paid integration combination three different kinds storage hot cold water tanks electrical battery different scenarios presented combining storages showing impact terms money savings reduction electrical energy purchasing national grid grid connected mode island mode operation spm considered analysis performed considering time dependent nature energy demands throughout whole year implementing experimental design curves real devices installed grid elsevier ltd rights reserved
primary cutaneous follicular helper cell tfh lymphoma recently described variant peripheral cell lymphomanot otherwise specified particular variant usually presenting sudden onset multiple plaques nodules characterized tumoral atypical cells express array tfh markers inducible cell costimulator bcl cxcl authors present patients whose known clinical skin findings consistent ptcl tfh origin ptcl tfh typically protracted pattern skin disease manifesting scaly patches plaques encountered mycosis fungoides seen cases distinguishing light microscopic phenotypic features cases similar previous reported cases ptcl tfh although systemic involvement seen categorization additional patients ptcl subtype medical literature would needed characterize new entity may lead better targeted treatments based specific cell subtypes
paper introduces design implementation plug free online interactive laboratory based networked control system laboratory ncslab framework system relying html provides full supports control engineering experimentation users allowed design control algorithms apply remote test rigs using web based interface multiple widgets real time charts virtual gauges live images available customize monitoring interfaces enhance sense immersion animations synchronized remote experimental processes also provided users watch interact remote experiments replicas various html based toolkits integrated seamlessly ncslab framework ncslab provides visualized services whole process control experimentation including remote monitoring tuning configuration control algorithm implementation network delay could disturb representation communication scheme using web protocols also implemented feedback teaching shows general acceptance effectiveness ncslab notably high existing online laboratories adopt either native applications plugins methodologies technologies used ncslab could insightful online laboratories toward webbased cross platform systems
software defined networking sdn emerging paradigm breaks vertical integration traditional networks provide flexibility program network logical centralized network control sdn capability adapt network parameters fly based operating environment decoupled structure sdn serves solution managing network flexibility ease sdn centralized cost effective architecture provides network visibility helps achieve efficient resource utilization high performance due increasingly pervasive existence smart programmable devices network sdn provides security energy efficiency network virtualization enhancing overall network performance present various security threats resolved sdn new threats arise result sdn implementation recent security attacks countermeasures sdn also summarized form tables also provide survey different strategies implemented achieve energy efficiency network security sdn implementation effort anticipate future evolution new paradigm discuss main ongoing research efforts challenges research trends area paper readers thorough understanding sdn architecture different security attacks countermeasures energy efficiency
innervation mammalian pineal gland prenatal development poorly recognized therefore immunofluorescence studies pineals day old foetuses domestic pig performed using antibodies tyrosine hydroxylase dopamine beta hydroxylase beta neuropeptide npy terminal flanking peptide npy cpon investigated glands supplied numerous nerve fibres containing beta density fibres higher distal middle parts gland proximal one npy cpon identified majority beta positive fibres well small population beta negative fibres localized mainly proximal part pineal immunoreactive fibres numerous day old foetuses day old ones effect norepinephrine melatonin secretion foetal pineals short term organ culture studied determine role beta positive fibres prenatal life purpose melatonin measured blood umbilical cords jugular vein mother pineals groups foetuses secrete melatonin organ culture independently presence absence norepinephrine medium melatonin concentrations blood umbilical cords foetuses litter jugular vein mother similar presence adrenergic nerve fibres pig pineal gestation seem associated control melatonin secretion
wireless power transfer wpt wireless energy transmission transmission electrical power power source consuming device without using solid wires conductors paper describe implementation concept wireless power transfer transmit power mobile phones mobile phones design use simple inductive coupling basic electrical circuits implement technology
purpose review goal review characterize food allergy management anaphylaxis schools assess current policies level preparedness schools recognize treat anaphylaxis recent findings increasing number school aged children food allergies studies show significant number school children known history allergies experience first anaphylactic reaction school stock unassigned epinephrine auto injectors recommended schools mandatory states therefore epinephrine always available non nursing staff members sometimes administering epinephrine due limitations nurse staffing summary wide variations staff training lack stock epinephrine leave many schools inadequately prepared manage anaphylactic reactions emphasis placed ensuring schools stock epinephrine also training wider range school staff members minimize treatment delay epinephrine improve clinical outcomes
reflection investigates questions arise one attempts write lives together intellectual theoretical implications mode biographical writing might seductions creative possibilities considers place invisible figures group biography argues genre enables recovery figures particularly productive ways focus rests individuals interstices two women receive particular attention first elizabeth kent sister law radical romantic journalist leigh hunt second virginia edgar friend correspondent mary anne disraeli reflection explores happens versions past construct figures disappear dominant cultural narratives group biography enables recovery theoretical pitfalls inherent returning foreground sustained focus creative experience suggests way deploying possibilities group biography act resistance towards posthumous anachronistic constructions significance argues resistance potential creatively liberating
paper provides overview development implementation three year industrially supported sports technology bachelor degree programme optional placement year industry within school mechanical manufacturing engineering loughborough university paper describes engagement course providers industry students encouraged integrated curriculum highlighted degree programme flourished direct result already strong research activities area attention given structure content programme links discussions held sporting goods industry aspirations career destinations students graduates initiated many industry activities believe key factor attracting increasing student numbers examples include one year student placements industry industry sponsorship undergraduate projects extensive donations equipment teaching purposes ongoing input departmental industry advisory board programme steering group includes senior industry academic sports governing body representatives addition industry involved directly teaching includes visiting lectures site visits factory tours emphasis given needs industry accommodated industrial support sought subsequently integrated programme insights gained student feedback forms discussed hoped paper interest others operating similar programmes perhaps importantly currently considering work operatively industry enhance engineering education undergraduate students
importance computer simulations assessment nuclear plant safety systems increased dramatically last three decades systems interest include existing proposed systems operate example normal operation design basis accident conditions severe accident scenario beyond design basis role computer simulations especially critical one interested reliability robustness safety high consequence systems physically tested fully representative environment european framework sarnet project european commission funded phebus fpt experiment chosen code benchmark exercise assess status various codes used severe accident analyses light water reactors aim benchmark assess capability computer codes model integral way physical processes taking place severe accident pressurised water reactor pwr starting initial stages core degradation fission product actinide structural material release transport primary circuit behaviour released fission products containment fpt benchmark well supported participation organisations countries using different codes temperature history fuel bundle total hydrogen production well captured code able reproduce accurately final bundle state using bulk fuel relocation temperature temperature first significant material relocation observed experiment total volatile fission product release well simulated kinetics generally overestimated concerning modelling semi volatile low volatile structural material release models need improvement notably substantial difference bundle fuel release experimentally observed due retention cooler upper part bundle retention primary circuit well predicted due mainly non prototypic formation boron rich blockage rising line fpt steam generator simulated circuit single external cooled tube deposition mechanism volatility elements could better predicted containment vessel thermal hydraulics designed experiment well mixed well calculated concerning containment aerosol depletion rate stand alone cases input data derived experimental data provided acceptable results whilst integral cases input data came circuit calculations tended largely overestimate total aerosol airborne mass entering containment disagreement calculated total aerosol airborne mass containment vessel measured one due combination general underestimation overall circuit retention overestimation fission product structural material release calculation iodine chemistry containment turned major challenge quality strongly depends correct prediction chemistry speciation integral codes major difficulties related presence high fraction iodine gaseous form primary circuit test correctly reproduced codes inability codes compromised simulation observed iodine behaviour containment benchmark significant user effect detected different results obtained different users code taken account analysing results article reports benchmark results comparing main parameters calculated observed summarising results achieved identifying areas understanding needs improved relevant experimental theoretical work way resolve issues raised elsevier ltd rights reserved
discovery noncoding rnas ncrnas importance gene regulation led develop bioinformatics tools pursue discovery novel ncrnas finding ncrnas novo challenging first due difficulty retrieving large numbers sequences given gene activities second due exponential demands calculation needed comparative genomics large scale recently several tools prediction conserved rna secondary structure developed many designed uncover new ncrnas slow conducting analyses large scale present various approaches using database ribogap primary tool finding known ncrnas uncovering simple sequence motifs regulatory roles database also used easily extract intergenic sequences eubacteria archaea find conserved rna structures upstream given genes also show extend analysis choose best candidate ncrnas experimental validation elsevier inc rights reserved
increase computer performance continues support practice large scale optimization computers multiple computing cores vector processing capabilities widely available investigate recently introduced advanced vector instruction avx set intel compatible architectures exploited interior point methods linear nonlinear optimization focus data structures implementation techniques utilize new vector instructions numerical experiments demonstrate avx instruction set provides significant performance boost implementation large scale problem significant fill sparse cholesky factorization achieving gigaflops performance standard desktop computer linear optimization problems required cholesky factorization relatively dense
previous research suggested important role emotion hatred intergroup aggression recent theoretical empirical work strongly suggested combination anger contempt disgust ancodi comprise basic elements hatred key emotions associated intergroup aggression study however provided evidence emotions cause hostile cognitions specific groups report two studies provide initial evidence participants members ideologically motivated groups primed ancodi study participants primed ancodi produced aggressive cognitions relative opponent outgroup neutral outgroup effect occur participants primed fear sadness study participants primed ancodi engaged competitive decision making opponent outgroups neutral outgroup effect occur participants primed disgust findings contribute literature role emotion intergroup aggression hostility provide nuanced view role emotions intergroup relations possibly identifying basic emotional elements hatred wiley periodicals inc
high achievement expectations academic pressure parents implicated rising levels stress reduced well among adolescents study affluent middle school youth examined perceptions parents emphases achievement relative prosocial behavior influenced youth psychological adjustment school performance examined perceived parental criticism possible moderator association data collected female middle school students predominately white upper middle class community students reported perceptions parents values rank ordering list achievement prosocial oriented goals based believed valued mothers fathers child achieve data also included students reports perceived parental criticism internalizing symptoms externalizing symptoms self esteem well school based data grade point average teacher reported classroom behavior person based analyses revealed six distinct latent classes based perceptions mother father emphases achievement class comparisons showed consistent pattern healthier child functioning including higher school performance higher self esteem lower psychological symptoms association low neutral parental achievement emphasis whereas poorer child functioning associated high parental achievement emphasis variable based analyses interaction effects showed elevated maladjustment high maternal achievement emphasis coexisted high low perceived parental criticism results study suggest foster early adolescents well affluent school settings parents focus prioritizing intrinsic prosocial values promote affiliation community least much prioritize academic performance external achievement strive limit amount criticism pressure place children
cultural values regarding gender roles encourage gender discrimination practice sex selection increasing political work force participation women challenges norms exploiting implementation indian law required one third local political seats reserved women investigate impact female leadership sex selection rural india find increase survival higher birth order girls political seats local level reserved women argue likely underlying mechanism change beliefs due exposure female leaders
urban streams could concurrently bring positive amenities accruing view waterscape negative disamenities associated water pollution paper focus specific question yet explicitly answered extant literature estimate cumulative impacts urban streams refer combined impacts amenities disamenities multiple sources high density high rise urban contexts typical residential apartment complex comprised number apartment units located dozens mid high rise commercial apartment buildings contiguous land parcel guangzhou south china used case study detailed palette natural amenities environmental disamenities two bifurcated streams quantified via generalized spatial two stage least squares gssls model model originally constructed spatial connectivity matrix cube contiguity applied address sophisticated manner array endogenous exogenous error interactions along horizontal vertical dimensions inherently exist spatial context high rise housing markets results spatial hedonic models micro neighborhood level demonstrate homebuyers tend evaluate urban streams chemical physical ecological features holistically cumulative impact also found homebuyers would like pay extra premium apartment located farther away polluted streams study advances extant literature contributing novel effective extension conventional two dimensional spatial matrix capture long ignored spatial correlation existing amongst apartment units located contiguous floors well robust estimation demand urban natural environmental amenities gradually rising mid high rise housing market developing developed countries
recent years become easy people far apart communicate telephone mail however neither telephone mail create feeling two people sharing space possible feel physically close someone far away ability communicate would significantly enriched purpose study propose system communication would enable two people feel place despite far apart first experiment conducted using types visual information ascertain types visual information effectively created illusion two separated people sharing space experiment showed simple visual information effective complex visual information creating illusion shared space based results research team able propose new system communication using table various projected visual objects system participant put hot drink example cup coffee table red circle would appear blink slowly position person table fading away conversely participant put cold drink table blue circle would projected onto person table position first person moved cup glass table red blue circle would repeat move blink slowly fade away person table second experiment used participants ascertain effectiveness proposed communication system found participants used proposed communication system felt person communicating shared space moreover participants felt proposed communication system enhanced communication making feel proactive clear participants experienced sense shared space strongly circle moved blinked faded away results suggest proposed communication system using table various projected visual objects succeed creating impression two people different locations sharing space
paper show neurally implemented cognitive architecture evolutionary dynamics solve four tree problem model called darwinian neurodynamics assumes unconscious mechanism problem solving insight tasks darwinian process based evolution patterns represent candidate solutions problem stored reproduced population attractor networks first experiment used human data benchmark showed model behaves comparably humans shows improvement performance pretrained primed appropriately like human participants kershaw experiment second experiment investigated effects pretraining priming two two design found beginner luck type effect solution rate highest condition primed pretrained patterns relevant task third experiment showed deficits computational capacity learning abilities decreased performance model expected conclude darwinian neurodynamics promising model human problem solving deserves investigation
paper presents home area network han based domestic load energy consumption monitoring prototype device part advanced metering system ams device placed individual loads configured measure several loads whole wireless communication infrastructure supported ieee radios run zigbee stack data acquisition concerning load energy transit processed real time main electrical parameters transmitted link wireless terminal unit works data logger human machine interface voltage current sensing implemented using hall effect principle based transducers code developed two bit microcontroller units mcus main features design options thoroughly discussed main contribution paper proposed metering system measures reactive energy component hilbert transform low cost measuring device systems
tree rings precious natural archives assess ecosystem variability time xylem anatomy woody tissue promising source information tree rings since closely linked tree hydraulics carbon fixation however despite rising interest cell anatomy dendrochronology still little known interpretation variability cell anatomical responses observed across different environments species analyze cell anatomical responses increasing summer drought trees conifer species picea obovata pinus sylvestris larix sibirica growing transition zone forest steppe republic khakassia russia analyses include comparison tracheid size distributions along climatic gradients contrasting micro topography results indicate overall decrease earlywood tracheid lumen cell wall thickness high temperature drought regardless species site conditions particular increase one degree celsius summer caused reduction earlywood cell lumen wall thickness anatomical shifts suggest downscaling hydraulic efficiency paralleled increased hydraulic safety presumably due carbon limitation based results case study suggest increasing drought stress might hamper formation functional xylem structure thus possible trigger miss acclimation causing long term decline higher exposure hydraulic failures despite promising study approach studies including data trees years broader climatic gradients would needed improve mechanistic understanding elsevier gmbh rights reserved
boolean control networks bcns discrete time dynamical systems boolean state variables inputs interconnected via boolean functions bcns recently attracting considerable interest computational models genetic cellular networks exogenous inputs topological entropy bcn inputs nonnegative real number interval log roughly speaking larger topological entropy means asymptotically control powerful derive necessary sufficient condition bcn maximal possible topological entropy condition stated framework cheng algebraic state space representation bcns means verifying condition incurs exponential time complexity also show problem determining whether bcn state variables inputs maximum topological entropy hard suggesting solved general using polynomial time algorithm elsevier ltd rights reserved
importance leadership improving educational outcomes schools widely promoted however nature leadership practices context received less attention educational leadership literature article present case study specific leadership practices developed one school site serving learning needs students complex diverse low socio economic community south east queensland australia rather focusing person role leader various leadership qualities traits examine nature particularity leadership practices praxis across variety roles dispositions developed within school help make sense praxis particularity educational leadership practices draw upon recent neo aristotelian practice theory reveal specific actions doings dialogue sayings relationships relatings constituted leadership practice praxis sayings relatings praxis evident formal leadership practices responsive context history particular school site formal informal leadership practices involved establishing leadership group within school address students needs informal leadership practices focused cultivating teacher learning student learning approach simply reinforce sedimented notions constitutes educational leadership sheds new light upon nature leading practices praxis
international society nephrology global organization members countries mission advance diagnosis treatment prevention kidney diseases developing developed world delivers mission low resource settings five education training programs available exclusively low middle income countries programs designed enable sustainable growth capacity nephrology related disciplines provide basis improvement care kidney patients worldwide also directs efforts towards advocacy kidney health kidney care seeking increase understanding kidney disease among general population health professionals health policy makers advocacy challenging complexity kidney health messages need emphasize affordable healthcare solutions prevention treatment acute kidney injury aki well prevention management chronic kidney disease ckd provision renal replacement therapy chronic dialysis kidney transplantation affordable ethically acceptable
work photovoltaic energy station system proposed power converters designed transfer energy source storage underwater autonomous vehicle auv load plus variable load station efficient regulation energy achieved linear control track bus voltage energy management power configuration composed converters digital control using matlab software order calculations mathematical formulation system analyzed local stability controlability gains controllers choice two methods siso tool matlab stability gain analysis based transfer function stability proof analysis converters demonstrated routh hurwitz even variation load station simulation evidence results performance improvement shown
paper proposes precise line sight los vector estimation using inter satellite radio frequency system gnss like technology inherited ranging signals locally generated inside formation however approach differs standard gnss model usage los vector unit length fully explored priori constraint carrier phase integer ambiguity resolution constraint lumped mapping process real valued ambiguities integers called validation subset ambiguity bounding two approaches rules regarding constraint gateway accept reject ambiguity candidates differ using ambiguity set subset ambiguity show remarkable improvement lower integer fixing failure rates without treating constraint validation provides slightly better performance subset ambiguity bounding terms integer fixing failure rates computational efficiency predefined tolerance regions critical two methods analytically determined function carrier noise paper also introduces los dependent ambiguity dilution precision adop los measure serve metric characterize expectation able successfully resolve ambiguities region adop los lower empirically summarized safe region integer fixing failure rates less closed form adop los derived able capture impact various factors antenna baseline geometries multiple frequencies form ultra boc signal structure demonstrated important influencing factors multiple properly arrayed antennas using ultra boc structure instantaneous ambiguity resolution achieved los accuracy reach millimeter level cospar published elsevier ltd rights reserved
alignment free methods one mainstays biological sequence comparison assessment similar two biological sequences fundamental routine task computational biology bioinformatics gained popularity since even standard desktop machines faster methods based alignments however advent next generation sequencing technologies datasets whose size number sequences total length challenge execution alignment free methods standard machines quite common propose first paradigm computation mer based alignment free methods apache hadoop extends problem sizes processed respect standard sequential machine also granting good time performance technically opposed standard hadoop implementation effectiveness achieved thanks incremental management persistent hash table map phase task contemplated basic hadoop functions useful also contexts
composite winding process pressure fluctuation affect density homogeneity products make interfacial strength disaccord fiber volume fraction order improve guiding precision stability winding pressure bearing guide replaced rolling guide designing pressure guiding mechanism parametric model guiding mechanism established based dynamics experiment joint surfaces analyzing modal harmonic response corresponding measures improvement proposed experimental results show designed guiding mechanism based rolling guide high precision perfect stability additionally roundness error installation error mandrel cause winding pressure fluctuate gas compressibility nonlinear flow dead zone cylinder friction measurement noise nonlinear disturbances significant impact pneumatic pressure control system considering circumstance adaptive fuzzy proportional integral derivative pid controller based grey prediction proposed predicting output pressure trend pressure signal reflected accurately provides reliable basis decision making fuzzy pid controller simultaneously two separate fuzzy inference systems employed adjust step length predictive control scale factor step self tuning algorithm simulation experimental results show fuzzy pid controller based grey prediction shorter settling time smaller overshoot error stronger robustness interference immunity designed guiding mechanism control algorithm effectively improved precision stability pressure control system composite materials winding formation
current control software brewer ozone spectrophotometer created years ago dos computers poor compatibility modern software hardware platforms new cross platform software controlling brewer able run actual operating system computers tablets smartphones time one codebase observation data configuration constants spectrophotometer stored embedded relational sqlite database core application written based cross platform framework observation routines implemented script interpreted scripting language integrated core application
report experiment investigating whether dancing music enhances recall person related memory targets experiment used dancers unaware experiment aim two channel silent disco radio headphones marked dance floor two types music memory targets sash colors symbols trial dancers wore radio headphones one four different colored sashes half carried cat symbols using silent disco technology one type music surreptitiously transmitted half dancers music different tempo transmitted remaining dancers pre experiment dancers faces photographed post experiment dancer presented photographs dancers asked recall memory targets results showed music dancing significantly enhanced memory sash color sash symbol findings discussed light recent eye movement research showed significantly increased gaze durations people observing music dance synchrony versus music dance asynchrony relation current literature interpersonal entrainment group cohesion social bonding
skin self care part human life birth death today many different skin care practices preferences traditions routines exist parallel addition preventive therapeutic skin care delivered nursing healthcare formal informal caregivers aim contribution critical discussion skin care context professional nursing practice explicit skin assessment using accurate diagnostic statements needed clinical decision making special attention paid high risk skin areas may either dry moist safety perspective protection maintenance skin integrity highest priority skin cleansing removal unwanted substances skin surface despite cleansing efficacy soap surfactants water inevitably always result destruction skin barrier thousands products available hydrate moisturize protect restore skin properties dependent upon formulation concentration ingredients products intended left contact skin exhibit several actions skin interfering skin biology unwanted side effects include hyper hydration disorganization lipid bilayers stratum corneum dysfunctional barrier increased susceptibility irritants allergies increases skin surface skin barrier impaired appropriate interventions apply lipophilic products sufficient quantity treat dry skin protect skin exposure irritants provided key statement contribution every skin care activity matters every time something placed skin functional structural response provoked response either desired undesired beneficial harmful choice skin care interventions nursing healthcare practice must based accurate assessment skin concomitant health conditions clearly defined outcome standardized skin care skin care product language needed researchers planning conducting clinical trials reviewers systematic reviews evidence base summaries nurses healthcare workers deliver evidence based safe skin care published elsevier ltd
authors proposed new method automatically mesh computed tomography based threedimensional human airway geometry computational fluid dynamics cfd based simulations pulmonary gas flow aerosol delivery traditional methods construct mesh realistic geometry time consuming done manually using image processing mesh generating programs furthermore thoracic image data sets include upper airway structures overcome issues proposed method consists cfd grid size distribution automatic meshing algorithm addition laryngeal model along turbulent velocity inflow boundary condition attached proximal end trachea method based previously developed geometric model irregular centerlines cross sections fitted segmented airway surfaces dubbed fitted surface model new method utilizes anatomical information obtained one dimensional tree skeleton connectivity branch diameters efficiently generate optimal cfd mesh automatically impose boundary conditions systematically reduce simulation results aerosol deposition predicted proposed method agreed well prediction traditional based model laryngeal model generated realistic level turbulence trachea furthermore computational time reduced factor two without losing accuracy using proposed grid size distribution new method well suited branch branch analyses gas flow aerosol distribution multiple subjects due embedded anatomical information elsevier ltd rights reserved
development network technology computer software developing two story structure model multi layer structure multilayer structure middleware key layer application layer application software development become new technology databases operating systems form basis computer software computer software application environment increasingly complex design multi layered architecture use software layering modularity allows software process become clearer easier maintain extend enhance flexibility computer software development adaptability thus stratification technology widely used modern computer software development
space spatiality thorn philosophy side time immemorial spatiality immediately associated corporeality finitude even death properly speaking constituted problems philosophy enigmas posed philosophy disrupt cool complacency root difficulty seems rests nothing prejudice rightful domain philosophy time understood pure continuous duration image eternity compartmentalised units space always plural province cartographers geographers certainly philosopher lost transcendent contemplation follows preliminary study better etude deploying variations single theme liberate space cartesian grid imprisoned long open free expanse might think space form duration without breaks without borders without boundaries last instance pure void another name consciousness
sleep disturbances children autism spectrum disorder asd exist worldwide little known issue non western cultures study aimed characterize sleep disturbances chinese children asd examine associated sociodemographic factors emotional behavioral problems parents chinese children asd aged years shenzhen china completed children sleep habits questionnaire cshq strengths difficulties questionnaire sdq sleep disturbances severe common rates overall disturbances daytime sleepiness sleep duration specific domains severity rate sleep disturbances higher compared previous studies typically developing children region china american children asd respectively significant correlations cshq sdq domains female gender older parental age higher hyperactivity poorer prosocial behavior associated increased overall sleep disturbances
conventional online education platforms implement combination static ptz pan tilt zoom cameras costly also require operators high computational power paper establish real time face tracking system based single ptz camera automatic operation cost effective solution proposed system takes account camera movement network delays tracking algorithm design maintaining cost flexibility practical implementation
objective constipation common symptom affecting western population strongly associated presence intestinal methanogens may directly inhibit motor activity two recent studies performed adult children affected chronic constipation showed supplementation reuteri significantly improved bowel movements whether action related decreasing methane production never tested therefore designed study aimed testing hypothesis patients methods data adults females mean age affected functional constipation treated probiotic reuteri dsm weeks performed lactulose breath test lbt institution showing production higher ppm retrospectively analyzed march june data recorded stool diary reporting frequency defecations stool consistency also analysed well result lbt performed end treatment reuteri results four weeks reuteri administration associated significant decrease mean production determined lbt auc value moreover total disappearance production ppm lbt observed patients observe significant decrease production conclusions study highlights first time beneficial effect lactobacillus reuteri dsm chronic constipation via significant decrease production
consider problem sampling points collection smooth curves plane crust family proximity based reconstruction algorithms rebuild curves reconstruction requires dense sampling local features parts curve close euclidean distance far apart geodesically show epsilon sampling sufficient proposed hnn crust variant improving upon state art requirement epsilon sampling thus may reconstruct curves many fewer samples also present new sampling scheme reduces required density even epsilon sampling achieve better controlling spacing geodesically consecutive points novel sampling condition based reach minimum local feature size along intervals samples mathematically closer reconstruction density requirements particularly near sharp angled features prove lower upper bounds reach sampling density terms lfs epsilon sampling demonstrate typically reduce required number samples reconstruction half
introduction important understand interactions processes issues occur within telerehabilitation interventions inform research practice aim study identify difficulties reported intervention features captured helpful notes written occupational therapists telerehabilitation trial method administrative documentation form subjective objective assessment plan notes collected trial examined effectiveness three teleconference delivered interventions physical activity alone fatigue management physical activity contact control social support people multiple sclerosis results five themes emerged desiring change taking action experiencing difficulty infrastructure support relief appreciation desiring change captured therapists observations clients desire manage symptoms improve participation apparent beginning supported clients taking action interventions progressed therapists identified difficulties group facilitation time management clients difficulties intervention materials infrastructure support reported helpful minimizing difficulties end therapists expressed relief clients appeared benefit appreciate interventions conclusion study highlights need importance providing resources training support teleconference delivered interventions clinical practice
new concept electrical shunt different materials aluminum copper developed used alternative current measurement device device provides better current measurement characteristics compared conventional current measurement devices shunt resistor ammeter multiple shunts consisting molybdenum low temperature coefficient rogowski coil integrated circuit currents several electrical circuits measured using developed current voltage transferring device cvtd voltages aluminum copper elements measured voltages proportional measuring currents shown following experimental equation coefficient depending configuration cvtd institute electrical engineers japan published john wiley sons inc
background reduced insulin insulin like growth factor signaling iis major cause symmetrical intrauterine growth retardation iugr impairment cell proliferation prenatal development results global growth defects mental retardation drosophila chico encodes insulin receptor substrate similar animal models iugr chico mutants defects global growth associative learning however physiological molecular bases learning defects caused chico mutations symmetrical iugr clear results study found chico mutations impair memory associated synaptic plasticity mushroom bodies mbs neural centers olfactory learning mutations chico reduce expression rutabaga type adenylyl cyclase rut leading decreased camp synthesis mbs expressing rut transgene mbs restores memory associated plasticity olfactory associative learning chico mutants without affecting growth thus chico mutations disrupt olfactory learning least part reducing camp signaling mbs conclusions results suggest cognitive defects associated reduced iis may occur independently developmental defects acute reductions camp signaling
shown reflection type dispersive delay structure dds units inherently superior transmission type dds units terms analog signal processing resolution since provide higher group delay swing however dds units suffer drawback requiring circulator separate input output signals order solve issue paper presents dds unit formed combining two identical dds units hybrid coupler proposed dds unit experimentally demonstrated two unit dds provide resolution enhancement one order magnitude compared purely dds counterpart
paper algorithm designed shooting games strong background light six leds uniformly distributed edge game machine screen located four corners middle top bottom edges three leds enlightened odd frames three enlightened even frames simulator furnished one camera used obtain image leds applying inter frame difference even odd frames resulting images six led six bright spots obtain leds coordinates rapidly proposed method based area bright spots calibrating camera based pinhole model four equations found using relationship image coordinate system world coordinate system perspective transformation center point image leds supposed virtual shooting point perspective transformation matrix applied coordinate center point obtain virtual shooting point coordinate world coordinate system game player shoots target two meters away using method discussed paper calculated coordinate error less ten obtain coordinate results per second meets requirement real time system proves algorithm reliable effective
joint pain major clinical problem mainly associated osteoarthritis characterized articular cartilage degradation resulting complex chronic pain state includes nociceptive emotional cognitive manifestations memory impairment depressive anxiety like symptoms reported associated chronic pain leading decrease life quality study evaluated involvement endogenous dynorphin kappa opioid receptor kor system nociceptive emotional cognitive neurochemical epigenetic manifestations joint pain murine model monosodium iodoacetate mia used induce joint pain knockout mice kor kor prodynorphin pdyn wild type littermates kor pdyn mice developed mechanical allodynia intra articular injection mia allodynia significantly increased kor pdyn compared mice accordingly mutants showed increased microglial activation lumbar section spinal cord mia emotional responses evaluated measuring anxiety like behaviour elevated plus maze anhedonia depressive like behaviour cognitive alterations object recognition paradigm emotional cognitive impairments joint pain differently modified kor pdyn mice alterations corticotropin releasing factor crf amygdala hippocampus regulation histone acetylation amygdala suggest possible mechanism explain emotional cognitive manifestations results reveal specific involvement dynorphin kor system joint pain manifestations usually associated osteoarthritis elsevier ltd rights reserved
brain network comprising medial prefrontal cortex mpfc amygdala plays important roles developmentally regulated cognitive emotional processes however little known maturation mpfc amygdala circuitry conducted anatomical tracing mpfc projections optogenetic interrogation synaptic connections neurons basolateral amygdala bla neonatal adult developmental stages mice results indicate mpfc bla projections exhibit delayed emergence relative mpfc pathways establish synaptic transmission bla excitatory inhibitory neurons late infancy events coincide massive increase overall synaptic drive subsequent adolescence mpfc bla circuits modified excitatory synaptic strengthening well transient surge feedforward inhibition latter correlated increased spontaneous inhibitory currents excitatory neurons suggesting mpfc blacircuit maturation culminates period exuberant gabaergic transmission findings establish time course onset refinement mpfc bla transmission point potential sensitive periods development critical network
lattice problems considered key elements many areas computer science well cryptography important shortest vector problem approximate variants algorithms problem known lattice reduction algorithms currently practical lattice reduction algorithm problems block korkine zolotarev bkz algorithm variants authors optimise pruning preprocessing parameters recursive aborted extreme pruned preprocessing bkz lattice reduction algorithm improve results asiacrypt chen nguyen authors derive approximate closed form complexity formulas based sandpile model assumption model hanrot enumeration time allow simple estimation complexity without running simulation algorithm chen nguyen asymptotically suggests modified extreme pruning bounding profiles different parameters hence authors contributions optimising improving analysis complexity upper bound estimates presented chen nguyen based recursive bkz preprocessing model
present study designed experimentally investigate effect using alo distilled water nanofluid working fluid thermal efficiency glass passive circulation evacuated tube solar collector internal spherical coil inside horizontal tank volume fraction nanoparticles nanoparticles dimension triton surfactant used experimental study performance etsc using alo nanofluid water compared flow rate inside coil varied present study revealed maximum efficiency found vol nanofluids mass flow rate collector efficiency shows greater enhancement increasing volume fractions alo nanoparticles flow rate conclusions results suggest alo nanofluids used working fluids etsc absorb heat solar radiation convert solar energy thermal energy efficiently elsevier ltd rights reserved
background aims cases chronic diarrhea unexplained small bowel disorders may one causes aim study assess diagnostic yield clinical impact video capsule endoscopy vce patients chronic diarrhea methods retrospectively analyzed records october august vce nationwide database registry ninety one patients medical centers males females mean age years evaluated vce result chronic diarrhea results duration chronic diarrhea months positive diagnostic yield vce however exhibited inconsistent result negative abnormal findings consistent chronic diarrhea included erosions aphthous ulcers ulcers mucosal erythema edema lumina narrowing common diagnoses functional diarrhea associated irritable bowel syndrome patients crohn disease patients vce examination diagnosis changed patients hematochezia odds ratio confidence interval hypoal buminemia predictive factors positive diagnostic yield conclusions vce favorable diagnostic yield clinical impact management patients chronic diarrhea
research demonstrated military service members elevated risk range psychiatric problems mental health services use conduit symptom reduction remission nonetheless notable underutilization mental health services population systematic review aimed identify critically examine rates service use barriers facilitators care programs interventions designed enhance willingness seek care increase help seeking behaviors among current military personnel active duty national guard reserve overall peer reviewed articles identified inclusion across studies rate past year service use among service members mental health problems time frame based weighted averages studies identified common barriers care concerns regarding stigma career impact facilitators care positive attitudes toward treatment family friend support military leadership support among population although programs screening gatekeeper training developed reduce barriers leverage facilitators encourage service use research needed empirically test effectiveness interventions increasing rates service utilization critical areas future research treatment engagement among high risk population discussed elsevier ltd rights reserved
objectives assess prevalence sonographic visualization rotator cable patients symptomatic full thickness rotator cuff tears asymptomatic controls correlate rotator cable visualization tear size muscular fatty infiltration atrophy functional outcome patients rotator cuff tears methods fifty seven patients rotator cuff tears asymptomatic volunteers underwent shoulder sonography prospective assessment rotator cable rotator cuff tear responded functional outcome questionnaires shortened disabilities arm shoulder hand quickdash constant patients rotator cuff tears appropriate tests used correlate rotator cable visualization tear size functional outcome muscular fatty infiltration atrophy results patients rotator cuff tears included women men mean age years range years volunteers included women men mean age years range years rotator cable identified controls patients rotator cuff tears patients nonvisualization rotator cable correlated larger tears higher grades supraspinatus atrophy fatty infiltration significant correlation functional outcome scores quickdash constant infraspinatus fatty infiltration conclusions nonvisualization rotator cable prevalent patients symptomatic rotator cuff tears asymptomatic controls associated larger tear size greater supraspinatus fatty infiltration atrophy diligent assessment supraspinatus muscle done patients rotator cuff tears without visible rotator cable integrity anatomic structures may interdependent
near isogenic lines nils sweet sorghum genotype individual stay green loci introgressed used understand contribution stay green loci stem sugar accumulation remobilization drought stress exposure sugar starch content activities sugar metabolism enzymes levels expression studied source leaf panicle sugar storing internode three lines irrigated plants plants exposed brief drought exposure panicle emergence stage annotation genes respective stay green loci introgressed nils carried using bioinformatics tools leaves nils accumulated photoassimilates internodes accumulated sugar compared parent line drought stress exposure led decrease starch sugar levels leaves three lines increase sugar levels observed internodes nils sugar fluxes accompanied alterations activities sugar metabolizing enzymes well expression genes related sugar metabolism transport remobilization sugars stem internodes apparent nils subjected drought stress since peduncle supports panicle showed increase sugar content even photoassimation source leaves reduced several genes related carbohydrate metabolism located stay green loci probably contributed variation parameters studied
recent scholarship pastoral epistles shows addressing several controversies author one hand claims legitimate heir long standing pauline tradition seeks advance doctrine provides important information gender roles beginning christianity present article drawing mary douglas theory relationship social physical body compares gender ideals contained pastoral letters apocryphal acts paul thecla
location verification witnessed significant attention vehicular communication due growth number location based intelligent transport system applications traditional cryptography based techniques suggested secure verify location vehicles traditional techniques increase protocol complexity computational overhead due hoc nature vehicular network environments context study proposes two layered location information verification cum security lives technique based transferable belief model tbm layer tiles based verification performed using concepts virtual tiles roads received signal strength layer tbm based verification performed specifically belief presence vehicle tiles belief presence vehicle neighbour neighbouring vehicles combined collective belief attest location claim neighbour vehicle performance lives evaluated road based map based network environments single mixed multiple adversary vehicles considered network environments comparative performance evaluations attest benefits lives compared verification inference position using anonymous beaconing without using lives
mitogen activated protein kinase mapk cascades highly conserved signaling modules transduce externally perceived signals play crucial role plant defense pathogen attack present study turmeric curcuma longa complementary dna cdna encoding mapk gene responsive pythium aphanidermatum infection isolated using rapid amplification cdna ends race pcr designated clmpk based high homology arabidopsis atmpk full length cdna length carried open reading frame orf encoding amino acid polypeptide clmpk protein contains thr glu tyr tey motif activation loop common docking domain terminal end belong subgroup mapk family southern hybridization revealed single copy clmpk turmeric genome intron exon composition showed highly conserved nature signaling kinases across different species quantitative pcr showed high expression clmpk rhizome tissues mature turmeric plants analysis temporal expression revealed significant induction clmpk transcript response defense signaling molecules pathogen attack early stages ectopic overexpression clmpk arabidopsis plants resulted enhanced resistance botrytis cinerea constitutively high expression defense responsive genes like pdf pad aos acs acs etc results suggest clmpk substantiate characteristics atmpk orthologs defense necrotrophic infection plants
object oriented modeling oom become integral part design process construction due advances computer software despite advances remains tendency computer aided design cad used medium assist creation modification analysis optimization electrical instrumentation systems within heavy industrial engineering projects paper retrospective oom systems information model sim systems utility facility constructed engineering procurement construction epc contractor purpose undertaking construct ability assessment prior commencement construction presented discussed cad drawings cable schedule produced epc provided organization undertake constructability assessment errors omissions information redundancy identified quantified sim model used examine tender proposal construction subcontractor epc discrepancies identified suggested differences arose due prevailing errors omissions potential use sim construction quality assurance control examined suggested used ensure development built model provide realistic representation constructed asset safeguards integrity operations maintenance elsevier rights reserved
models care coordination significantly improve health outcomes older adults chronic illnesses engage participants purpose study examine impact nursing contact rate participants voluntary disenrollment care coordination program retrospective cohort study using administrative data participants health quality partners medicare care coordination demonstration program rate voluntary disenrollment approximately lower risk voluntary disenrollment associated greater proportion person telephonic nursing contact hazard ratio confidence interval higher risk voluntary disenrollment associated lower continuity nurses provided care findings suggest person nursing contact care continuity may enhance enrollment chronically ill older adults ultimately overall health well population
automated industries require high quality power supply better performance therefore power generating units play crucial role work multi area power system incorporates six area thermal power systems different steam configuration investigated automatic generation control agc investigated system included non reheat thermal power system area area single reheat thermal power system area double reheat thermal power system areas interconnected tie line proportional integral derivative pid controller proposed secondary controller provide necessary control signal sudden load demand achieve optimal pid controller performance controller gain values optimized considering nature inspired meta heuristic algorithm namely ant colony optimization aco technique using different objective functions time domain specification analysis considered evaluate performance investigated power system power system designed modeled matlab simulink environment finally simulation results established integra time absolute error itae objective function based pid controller provided superior performance compared objective function based pid controller
paper proposed present simple approach load flow analysis radial distribution network using parallel programming computationally unified device architecture cuda proposed approach applies breadth first search evaluate nodes network kirchhoff current law kcl well kirchhoff voltage law kvl evaluating current voltages network nodes procedure repeated till convergence criterion achieved paper demonstrates working breadth first search using cuda efficiency load flow algorithm enhanced utilizing parallel computational power graphics processing unit gpu approach tested nodes well nodes radial distribution systems comparison done performances sequential approach cpu parallel approach gpu results show introducing cuda load flow analysis speeds performance system faster executions gives accurate desired results compared sequential approach
realistic human model reconstruction important component computer graphics computer vision particular texturing surface models key stage reconstruction paper dispose texture mapping model surface optimization image stitching present effective method generate seamless integrated smooth texture surface human model first build corresponding markov random field model respect color images triangular meshes surface basis alpha expansion optimization markov random field model translation coordinate color image adaptive iterative factor introduced optimization match color content boundary adjacent meshes compensates misalignment adjacent color images caused inaccuracy depth data multi view misregistration apply poisson blending composite vector field gradient domain resolve small noticeable illumination variations different color images repair blank regions parameterize model surface project onto plane nearest neighbor algorithm applied fill blank regions texture contents finally evaluate method comparison another three advanced methods human models results demonstrate method images stitching creates best texture surface human model visual effect quantitative analysis
prove high probability choice random graph erdos renyi distribution time degree sum squares semidefinite programming relaxation clique problem give value least log constant yields nearly tight bound value program degree log moreover introduce new framework call pseudo calibration construct sum squares lower bounds framework inspired taking computational analogue bayesian probability theory yields general recipe constructing good pseudo distributions dual certificates sum squares semidefinite program sheds light ways hierarchy differs others
fully digital control pwm converters considerable research done based predictive current control pcc scheme however requires large amount calculation step experimental implementation besides compared classical linear control scheme sampling interval pcc scheme must shorter obtain control performance current due digital signal processor excellent performance required paper proposes improved simplified model pcc scheme three phase pwm converters main objective simplify pcc scheme also proposed control scheme able reduce calculation time without affecting performance simulations experiments carried investigate presented novel predictive current control scheme results indicate three phase pwm converter excellent static dynamic performance proposed scheme besides calculation time obviously shortened
six abomasums yaks bos grunniens studied gross dissection histological methods found mucosa yak abomasum covered simple columnar epithelium lots spiral folds fundic glandular area developed membrane lamina propria occupied high density glands according morphological characteristics glands abomasum divided cardiac gastric pyloric glands cardiac glands curved tubular glands intumescent bottom small glandular cavity fundic glands simple tubular glands branched tubular glands chief parietal mucous neck cells observed clearly pyloric glands curled tubular glands closer deep lamina propria obvious glands curl staining glycoconjugate revealed mucosal epithelium cardiac gastric pyloric glands gastric pits epithelium mainly secreted neutral glycoconjugate portions cardiac gastric glands secreted mixed acid glycoconjugate respectively gordon sweet reticular fiber staining found mucous neck cells possessed characteristic argyrophilic phenomenon large number argyrophilic granules supranuclear cytoplasm contrast chief cells furthermore isolated lymphoid nodules diffuse lymphoid tissue abomasum glands especially corpus abomasi grimelius silver staining showed argyrophil cells located glandular epithelium lamina propria glands also observed connective tissue endocrine cells dispersed individually epithelial cells occasionally cell groups therefore yaks grazed throughout year diverse natural grassland evolved morphological characteristics abomasum enabling consume wide variety plant species thereby better adapting harsh plateau environment
appropriate structural analysis optimization methods great significance conceptual design automotive body white biw structure paper simplifies biw structure spatial semi rigid framed structure provide early stage predictions novel exact transfer stiffness matrix method tsmm proposed static dynamic analyses three dimensional semi rigid framed structures matrix storage equation solution techniques large scale engineering structures also considered additionally size optimization mathematical model biw conceptual structure formulated solved genetic algorithm afterwards promote conceptual design biw structure object oriented matlab toolbox based tsmm developed unified modeling language uml strategy design pattern employed facilitate development toolbox distributed parallel computing technique adopted speed former sequential optimization algorithm simple modifications lastly validity easy used toolbox demonstrated benchmarking auto body elsevier ltd rights reserved
purpose evaluated impact positive youth development program adolescent pregnancy sexual behavior risky sex intentions nonmetropolitan florida high schools methods teen outreach program top compared standard school curriculum content using cluster randomized controlled trial design youth two cohorts majority youth years old ninth grade baseline treatment group youth received top health related classes using multiple imputation account missing data analyzed baseline follow survey data using generalized linear mixed effects models logit link function results cohort sample compared control condition males females receiving top showed lower odds engaging recent sex odds ratio confidence interval compared control males females cohort treatment females engage recent sex less likely risky sex fewer significant findings cohort though top females combined gender lower odds risky sex intentions respectively overall cohort females top condition group likely benefit top conclusions consistent previous research top effective regarding sexual health outcomes among female versus male youth especially true outcome risky sex however results consistent across cohorts prompting questions future research society adolescent health medicine rights reserved
photorealistic modeling rendering materials complex internal mesostructure hard challenge computer graphics particular macroscopic porous materials consist complex translucent substances exhibit different details light interaction several different scales state art techniques modeling porous materials manage material either surface set complex capture procedures volume employing different instances procedural noise models representation surface solution achieves several desired material properties still presents drawbacks practical applications high computational costs complex capture procedures poor image variability among others volumetric solutions flexible final structure appearance difficult control overcome drawbacks propose algorithm procedural generation porous materials method based artistic physically inspired simulation growth self avoiding bubbles inside volume means dynamical systems patterns induced bubbles easily intuitively controlled bubbles adapt given shape convincing global local fluid like patterns seen bread sponges method generates textures adequately represent porous materials used input creating realistic renderings different porous objects case study present results using textures input direct volume renderer show compare favorably standard texture synthesis methods copyright john wiley sons ltd
aim case report describe innovative orthodontic treatment method combined surgical orthodontic techniques novel method used achieve positive result case moderate crowding employing computer guided piezocision procedure followed use clear aligners year old woman malocclusion moderate crowding periodontal indices oral health related quality life ohrqol treatment time evaluated treatment included interproximal corticotomy cuts extending entire thickness cortical layer without full thickness flap reflection achieved three dimensionally printed surgical guide using computer aided design computer aided manufacturing orthodontic force applied teeth immediately surgery using clear appliances better control tooth movement total treatment time months periodontal indices improved crowding correction oral health impact profile showed slight deterioration ohrqol days following surgery year retention follow stability treatment excellent reduction surgical time patient discomfort increased periodontal safety patient acceptability accurate control orthodontic movement without risk losing anchorage may encourage use combined technique appropriate cases
well known existence unstable zero dynamics recognized major barrier many control systems usual digital control zero order hold zoh fractional order hold froh input used unstable zero dynamics inevitably appear discrete time model even though continuous time system relative degree two minimum phase paper investigates zero dynamics sampling period tends zero sampled data models composed generalized sample hold function gshf continuous time nonlinear plant sampler cascade precisely show approximate sampled data model obtained nonlinear systems two special gshf cases sampled zero dynamics resulting model arbitrarily placed two gshfs appropriate parameters provide nonlinear zero dynamics stable possible improved stability properties even unstable given continuous time plant also shown intersample behavior arising multirate input localised appropriately selecting design parameters based stability condition zero dynamics results presented generalize well known ideas linear nonlinear cases
objective aims current study determine whether childhood maltreatment contributes occurrence major depressive disorder mdd bipolarity suicidality methods total outpatients diagnosed mdd medical records included subjects divided two groups according presence childhood maltreatment group childhood maltreatment ncm group depression severity bipolarity identified using beck depression inventory bdi korean version mood disorder questionnaire mdq respectively medical records addition baseline loud dependence auditory evoked potentials patients medical records analyzed results mean total bdi bdi item suicide ideation total mdq score significantly higher group ncm group number subjects bipolarity significantly higher ncm group furthermore two thirds subjects experienced significant maltreatment childhood central serotonergic activity group also lower ncm group conclusion findings study support relationship childhood maltreatment bipolarity suicidality patients mdd
known low testosterone high cortisol levels associated hypertension well chronic stress linking stress elevated blood pressure however association acute stress chronic stress responses clear africans therefore examined association cortisol psychological distress responses low high male subgroups beat beat ambulatory blood pressure abpm electrocardiogram measures obtained serum samples collected analyzed sex hormones cortisol chronic psychological distress verified general health questionnaire acute stress cold pressor test chronic psychological distress observed low high africans compared caucasians low africans tended ischemic events abpm values groups chronic distress cortisol acute stress total peripheral resistance cold pressor responses associated abpm low african group acute chronic stress may contribute increased low african men cortisol vascular responses supported tendency ischemia increasing risk coronary artery disease
covert channels widely considered major risk information leakage various operating systems desktop cloud mobile systems existing works modeling covert channels mainly focused using finite state machines fsms transforms describe process covert channel transmission however fsm rather abstract model information shared resource synchronization encoding decoding presented model making difficult researchers realize analyze covert channels paper use high level petri nets hlpn model structural behavioral properties covert channels use hlpn model classic covert channel protocol moreover results analysis hlpn model used highlight major shortcomings interferences protocol furthermore propose two new covert channel models namely two channel transmission protocol tctp model self adaptive protocol sap model tctp model circumvents mutual inferences encoding synchronization operations whereas sap model uses sleeping time redundancy check ensure correct transmission environment strong noise demonstrate correctness usability proposed models heterogeneous environments implement tctp sap three different systems linux xen fiasco implementation also indicates practicability models heterogeneous scalable flexible environments
paper attempts integrate quality function deployment qfd method new product development npd cycle propose methodology evaluate voice customers designing innovative products results presented applying methodology focus first stage requirements capture design phase development actual product phase considered case study innovative newly patented product biometric identification system emergency cases research methodology inter multi trans disciplinary approach development innovative products context study npd pathway research steps follow qfd logic glue among specialists different fields like quality management electronics computer programming medicine methodology follows general steps qfd formalism consists developing mathematical model quantifies overall index call offset level customer requirements achievement technical characteristics designed developed innovative product authors published elsevier
electron density profiles retrieved constellation observing system meteorology ionosphere climate cosmic satellite radio occultation observations used derive ionospheric upper transition height density equal light ions mainly found ionosphere upper transition height low significant local time latitude seasonal variations extremely low solar minimum transition height higher daytime night except middle latitude region winter hemisphere transition height minimum morning pronounced peak equator seasons transition height higher summer winter hemisphere results comparability nofs satellite observations around equatorial region june august however iri model gives much higher transition height cosmic reproduce latitude season variations well elsevier ltd rights reserved
earlier studies shown level creativity fourth year students mechanical engineering manufacturing engineering programmes universiti kebangsaan malaysia low average reflected evaluation group based design projects based finding next cohort students several creativity techniques introduced course mind mapping combined conventional techniques design engineering includes morphology analysis pugh evaluation matrix students required apply techniques report implementation log books observed students creative able propose ideas box thinking achievements showed creativity level enhanced teaching learning order ensure effective infusion creativity among students mechanical engineering manufacturing engineering programmes proposed students exposed effective creativity techniques combined standard engineering design methods generating ideas students introduced creative techniques design based courses first year university published elsevier ltd selection peer review responsibility kongres pengajaran pembelajaran ukm
design build regarded effective means delivering high performance green buildings selection contractors critical importance objective study evaluate selection design builders public buildings seeking leadership energy environmental design leed certification compare selection practices involved non leed seeking projects robust content analysis requests proposals rfps public projects results content analysis reveal level leed certification dominant means conveying sustainability requirements rfps contractor selection majority rfps including sustainability requirements part contractor evaluation package exception contractors past performance statistically significant difference importance weights selection criteria leed seeking non leed seeking buildings owners tend place emphasis innovative technical solutions rather past performance contractors additionally research findings also indicate owners leed seeking building projects tend provide fewer design decisions rfps solicit innovative design alternatives potential contractors study provides owners number practical implications selecting appropriate design builders green projects american society civil engineers
childhood obesity one common eating disorders prevalence overweight obese children growing rapidly worldwide developed developing countries obesity early years child life particularly hazardous impact physical psychosocial development child individuals developed obesity even face difficulties treatment maintaining healthy body weight changes taken place generally people lifestyles play important role development childhood obesity omission breakfast change less nutritious diet reduction frequency meals taken family reduced number daily meals increase size food portions key factors contribute weight gain children people acquire early childhood essential behavior follows rest lives consequently development bad eating habits children usually persists adolescence adult life
degraded hills restored afforestation conserving soil water rainwater harvesting three slope categories viz degraded hill treated rainwater harvesting rwh structures contour trench gradonie box trench ditch including control view rehabilitate conserving minimizing gradient soil water nutrients soil water content swc height collar diameter acacia catechu azadirachta emblica officinalis holoptelia integrifolia zyziphus mauritiana planted august herbaceous biomass photosynthetically active radiation par interceptions tree vegetation tree vegetation combine par intt monitored suitability rwh devices tree species rehabilitation swc decreased december june linearly related rainfall vegetation height par int tree vegetation tree vegetation combine respectively helped conserve soil water swc plant vegetation growth par intt lowest whereas herbaceous biomass par intv highest slope vegetation height swc linearly related biomass indicating improvement micro climate herbaceous growth highest swc slope promoted plant growth mean annual increment mai height collar diameter enhanced par intt par intc variables highest treatments lowest control plots characteristic root distribution acacia catechu indica promoted growth ditch whereas officinalis mauritiana integrefolia performed best treatment rwh enhanced herbaceous biomass control conclusively structures found best growth herbaceous vegetation well catechu indica plants whereas structures favoured growth tree species rainfall influenced swc rwh helped conserve soil water promoted plantation herbaceous growth facilitated restoration process may promoted restore degrading lands elsevier rights reserved
family conservative truly nonlinear oscillators integer non integer order nonlinearity considered oscillators one odd power form elastic term exact expressions period solution found terms gamma functions cosine ateb function respectively values order nonlinearity possible obtain periodic solution terms common functions however family conservative truly nonlinear oscillators show paper possible obtain fourier series expansion exact solution even though exact solution unknown coefficients fourier series expansion exact solution obtained integral expression regularized incomplete beta function appears coefficients function order nonlinearity computed numerically one application technique compare amplitudes different harmonics solution obtained using approximate methods exact ones computed numerically shown paper example approximate amplitudes obtained via modified ritz method compared exact ones computed numerically elsevier rights reserved
women younger years may face early menopause premature ovarian failure pof cause pof idiopathic iatrogenic especially cancer induced oophorectomy chemo radiation therapy current treatments including hormone replacement therapy hrt cryopreservation techniques increased risk ovarian cancer may reintroduce malignant cells autografting decellularization technique regarded novel regenerative medicine strategy organ replacement wherein living cells organ removed leaving extracellular matrix ecm cellular seeding study aimed produce xenogeneic decellularized ovary ovary scaffold platform ovary regeneration transplantation developed novel decellularization protocol porcine ovary treatment physical chemical enzymatic methods using hematoxylin eosin staining dapi staining scanning electron microscopy sem quantitative analysis approach proved effective removing cellular components preserving ecm furthermore results biological safety evaluation demonstrated ovary tissues noncytotoxic rat ovarian cells vitro caused minimal immunogenic response vivo addition ovary tissues successfully supported rat granulosa cell penetration vivo showed improvement estradiol hormone secretion
manufacturing engineering bamboo fiber reinforced friction material introduced paper ansys used adaptive meshing establish contact impose constraints load solve temperature field bamboo fiber reinforced friction material obtained results showed coupling effect friction heat pressure brake blocks brake discs contact area showed local changes temperature stress characteristics thermal stress coupled parts contact surface showed inhomogeneous distribution contact pressure distribution temperature distribution interact contact pressure distribution coupled parts affects temperature distribution local feature temperature distribution coupled parts conversely affects contact pressure distribution provide important theoretical basis devising friction brake selecting material friction pair
new kind cloud service called database aservice daas provides novel paradigm allows data stored remote databases types database used remote sites divided two categories relational databases rdb nosql nosql databases store data flexible format without schema nosql databases easily scaled across multiple devices advantages nosql databases many large data applications use nosql databases backend data management system nosql databases usually access stored data files distributed file system problem decentralized data management critical nosql databases order address issue many energy efficient algorithms file placement used distributed file systems however energy efficient algorithms focus reducing power consumption storage systems ignore cost data reliability affected frequently setting disk status standby mode maintain data reliability energy efficient storage systems usually combine framework power conservation fault tolerance mechanism however developers energy efficient frameworks consider whether fault tolerance mechanism avoid data loss combination used energy efficient storage systems study proposes general energy efficient framework integrated different fault tolerance mechanisms experimental results show capability proposed framework different erasure code algorithms
objective purpose study test feasibility randomized clinical trial effectiveness combining spinal manipulation standard tobacco cessation counseling methods randomized clinical trial conducted participants intervention group received months counseling plus delivered doctors chiropractic whereas control group participants received counseling alone primary outcome measures smoking decreases day smoking abstinence measured tobacco diary urinary cotinine descriptive statistics calculated results recruitment proved difficult reluctance participants commit month course care ten participants completed pilot study counseling plus group participants greater improvement number cigarettes smoked urinary cotinine three participants achieved least days tobacco abstinence counseling plus group conclusions feasibility study doctors chiropractic appeared capable conducting effective smoking cessation counseling preliminary information indicated may benefit including chiropractic care addition counseling researchers conducting future studies adequately powered consider using multiple locations incentives adequate recruit participants
several studies meta analyses demonstrated efficacy combination nicotine replacement therapy nrt patients wish quit smoking however limited guidance respect initiation tapering combination nrt weattempt review evidence rationale behind combination nrt present dosing used combination nrt studies propose step approach tapering combination nrt integration behavioral strategies published elsevier inc
violence become public health concern united states violent visually stimulating content encompasses various techniques fear humor shock violence stimulate response appeal toward awareness human emotion exposing impressionable youth violent advertisements particularly problematic especially true places like new york city violent crime prevalent problem annual ridership reaching billion new york city subway system abundant advertisements purpose pilot study determine frequency type violent advertising lexington avenue east side line new york city running bronx manhattan represent lower higher median income earning boroughs statistically different findings median household income site station number ads source violent destruction common form violence followed intent strike showing weapon horror ads found stations heading uptown toward bronx borough median household income lowest whereas found stations heading downtown future studies could focus additional boroughs subways lines could collected multiple points time determine prevalent violent advertising throughout new york city different time frames
background march early aeroallergen sensitization subsequent respiratory allergy well established unclear whether early life food sensitization precedes increases risk allergic airway disease objective assess association food sensitization first years life subsequent asthma allergic rhinitis age years methods used data two independent cohorts high risk melbourne atopic cohort study macs population based lisaplus food sensitization assessed months macs months lisaplus multiple logistic regressions used estimate associations sensitization food aeroallergen allergic airway disease results compared non sensitized children sensitization food months macs months lisaplus associated increased risk current asthma aor macs aor lisaplus similar results seen allergic rhinitis additionally cosensitization food aeroallergen cohorts tested point stronger predictor asthma months aor macs aor lisaplus allergic rhinitis months aor macs aor lisaplus conclusions cohorts food sensitization without aeroallergen sensitization first two years life increased risk subsequent asthma allergic rhinitis findings support role early life food sensitization atopic march suggest trials prevent early onset potential reduce development allergic airways disease
paper presents sensorless control stall regulated variable speed wind turbine speed reference obtained estimated aerodynamic torque lqg ltr methodology applied design optimal discrete time feedback controller wind energy conversion system aiming maximize efficiency energy conversion minimize detrimental dynamic loads due wind fluctuation ripple torque trade efficiency maximization energy conversion dynamic load effects minimization considered quadratic cost function lqg ltr design resulting control structure simulated considering step variation wind speed performance proposed control scheme discussed showing really leads wecs operation near maximum efficiency point reduces detrimental dynamic loads also presented alternatives sensorless control electrical generator
large body research bilingualism revealed language processing fundamentally non selective simultaneous graded activation mental representations speakers languages equally deep tradition research code switching mixing revealed important role grammatical principles play determining nature bilingual speech propose integrate two traditions within formalism gradient symbolic computation allows formalize integration grammatical principles gradient mental representations apply framework code mixing constructions element intended utterance appears languages within single utterance discuss directions suggests future research
expression serotonin transporter protein ntt dorsal raphe nucleus dnr early postnatal period investigated laboratory wistar rats immunocytochemical labeling showed first postnatal weeks intensity ntt expression dnr control animals changes earliest postnatal stages dnr subnuclear neurons dorsal dnr ventral dnr lateral dnr lat found intensely express ntt ntt localization sites revealed membrane surface neuronal cell bodies processes neuropil number ntt expressing neurons ntt binding sites decreases time ntt binding sites shown undergo redistribution becoming neuronal cell bodies dendrites rather densely packed axonal membrane number ntt expressing neurons density ntt localization sites neuropil gradually increases age reduction serotonin level dnr regions prenatal development leads reduction number ntt expressing neurons ntt localization sites early postnatal period tendency shown persist age
paper presents multiscale modeling approach simulating self sensing behavior load sensitive smart polymer material statistical spring bead based network model developed bridge molecular dynamics simulations nanoscale finite element model macroscale parametric studies conducted developed network model investigate effects thermoset crosslinking degree mechanical response self sensing material comparison experimental simulation results shows multiscale framework able capture global mechanical response adequate accuracy network model also capable simulating self sensing phenomenon smart polymer finally molecular dynamics simulation network model based simulation implemented evaluate damage initiation self sensing material monotonic loading
aimto discuss available data links lutd sexual dysfunction still unknown causative effect disease processes sexual function suggest proposals research methodsat international consultation incontinence research society ici multi disciplinary group presented literature search known effect lutd men women wider discussions regarding knowledge gaps ideal research methodology ensued presented resultsthe underlying mechanisms impact lutd remain largely unknown risk factors metabolic syndrome may cause luts men improvement may improve conditions women neurovascular changes may common lutd fsd successful luts management results fsd improvement mechanisms ill understood gaps standardization sexual dysfunction terminology variations assessment treatment clinical practice research make studies comparable sensitive knowledge subjective nature problem present challenges often result neglecting conclusionneurovascular hormonal factors also indirect effects may link lutd sexes evidence robust mechanisms unclear need defining terminology standardizing outcomes assessed clinical trials multifactorial nature sexes makes trial design challenging real world studies may prove beneficial patients outcomes clinicians understanding
ambient intelligence paradigm envisions systems whose central entity user ami integrates technologies artificial intelligence implicit human computer interaction ubiquitous services capability ami systems oriented towards assistance humans work classroom even home consequence awl development process usually incorporates final user since first stages however users available long process always possible agent based social simulations users role played simulated entities used make awl development process faster effective scenario modelling cmhbs computational models human behaviour major challenge address issue paper proposes methodology whose main contributions use domain experts knowledge create cmhbs common methodological framework develop cmhbs combining information obtained sensors perceptions experts experiences open source tools support development paradigm paper also presents full case study hospital illustrates number recommendations made methodology techniques proposed mainly use ontologies temporal reasoning potential methodology model personnel hospital elsevier ltd rights reserved
paper presents approximate time domain solution physics based electrochemical lithium ion cell battery models time domain solution represented state space form easily used design state estimator controller uses interconnection system approach derive state space representation battery impedance model provides reduced order model based via balanced truncation method simulation results also provided show performance proposed model frequency domain elsevier rights reserved
paper deals realization fractional order impedance functions passive electrical networks composed fractional capacitor rlc components necessary sufficient conditions existence realization found general case also impedance functions described class fractional order transfer functions realizability conditions stated algebraic conditions parameters transfer function moreover procedure proposed implementation impedance functions passive electrical networks composed fractional capacitor rlc components numerical examples presented show usefulness results paper design fractional order electrical circuits
purpose work establish protocol combines cad modeling non destructive microscopic techniques confocal raman micro spectroscopy laser microscopy assess vivo hydrothermal stability zta femoral head retrievals combined effects wear biological environment vivo occurring peculiar events metal staining evaluated five retrieved zta femoral heads implantation time ranging months protocol relies application polar grid entire surface head divides small sectors sector automatically screened micrometer resolution maps finally linked toto view retrieved head becomes available three dimensions upon combining analytical techniques solid modeling computer aided design cad software becomes possible develop model femoral head comprehensively describes topographic crystallographic micromechanical characteristics entire surface immediate sub surface combination cad polarized ramanspectroscopy laser microscopy led toto screening femoral head micrometer scale resolution thus providing new comprehensive protocol quality assessments new components failure analysis retrievals elsevier ltd rights reserved
objectives natalizumab long term effectiveness data real world relapsing remitting multiple sclerosis rrms needed objective report long term effectiveness safety natalizumab cohort rrms patients methods retrospective study natalizumab treatment two years longer rrms annualized relapse rate expanded disability status scale edss brain magnetic resonance imaging lesion volume virus antibody status previous treatments adverse events analysed results seventy one patients included mean treatment duration months treatment duration significant decrease annualized relapse rate edss evidence clinical disease activity one two years respectively brain magnetic resonance imaging lesion volume remained stable forty patients suspended natalizumab due high risk developing progressive multifocal leukoencephalopathy pml major complication pml conclusions natalizumab showed effectiveness long term follow period cohort reduction arr edss mri lesion load stabilization pml major complication elsevier rights reserved
bone marrow transplant bmt units stressful work environments high staff burnout anxiety turnover qualitative study undertaken better understand care nurses within context clinical practice pediatric bmt unit understanding care practices bmt nurses allow design interventions provide appropriate support subspecialty nurses focus groups held nurses key participants focus groups general participants unit management caregivers inpatients data analyzed using thematic analysis data transcribed verbatim coded consensus members research team five themes emerged data experiencing stressful situations impede care growing developing personally professionally providing trustworthy respectful care acquiring meaningful coping skills sharing others versus isolation stress management professional development interdisciplinary communication areas emerged potential intervention
wavelength stabilization pulsed laser presents challenges continuous wave laser developed simple efficient long term wavelength drifts compensation technique tunable pulsed dye lasers pdl applied sodium detection lidar system wavelength calibration locking implemented using optogalvanic spectroscopy hollow cathode lamp hcl conjunction digital control software optimization signals better laser wavelength discrimination feedback control performed test results indicate locking multimode broadband pdl atomic transition corresponding well achieved although temperature laboratory unstable active compensation maximum wavelength drift reduced maximum wavelength drift rate pdl improved used efficient sodium resonance fluorescence lidar detection technique economical easy implement provides flexible wavelength control allows generalization applications require wavelength tunable pulsed lasers fixed atomic resonance transition references elsevier rights reserved
experiment students men women age years carried compare effect four techniques used mediators number agreements contracted negotiators experimental conditions mediators asked either rephrase reformulate negotiators words imitate show active listening behavior finally use free technique agreements reached active listening condition free rephrase conditions furthermore mediators active listening condition perceived negotiators efficient mediators using techniques although significant difference observed active listening imitation conditions
background prevalence hypogonadism hiv infected patients still matter debate standardized consensual diagnostic method addition etiology endocrine metabolic implications hypogonadism population remain controversial study aims determine prevalence testosterone deficiency single site hospital evaluate association potential risk factors lipodystrophy metabolic syndrome cardiovascular risk methods study analyzed hiv infected men combined antiretroviral therapy patients low total testosterone levels low calculated free testosterone levels considered testosterone deficient according fsh levels patients classified hypogonadotropic hypergonadotropic dysfunction clinical anthropometric analytic parameters also collected analyzed results prevalence testosterone deficiency population among hypogonadotropic dysfunction presented hypergonadotropic dysfunction patients testosterone deficiency older higher hbac levels higher systolic blood pressure patients lower testosterone levels higher prevalence isolated central fat accumulation higher median cardiovascular risk years measured framingham risk score year ascvd risk conclusions prevalence testosterone deficiency hiv population high hypogonadotropic dysfunction responsible majority cases testosterone deficiency might predispose involved pathogenesis hiv associated lipodystrophy patients low testosterone levels higher cardiovascular risk highlighting importance early diagnosis condition
objective saliva plays pivotal role antioxidant system saliva antioxidant levels reduced patients periodontal disease recently biochemical test able determine saliva antioxidant levels proposed predictive oral cavity diseases clinically tested preliminary study evaluated relationships periodontal screening recordings characteristics patients saliva antioxidant levels measures design thirty nine patients men women mean age years attending dental hygiene unit private clinic underwent periodontal screening recordings examination saliva antioxidant levels measurement using biochemical commercial test results clinical periodontal examination compared obtained saliva test results approximately patients showed low saliva antioxidant levels value patients optimal normal values thirteen patients resulted positive periodontal screening recordings test using periodontal screening recordings values gold standard saliva antioxidant levels test correctly classified patients sensitivity specificity conclusions saliva antioxidant levels test good sensitivity compared gold standard finding corroborates hypothesis alterations oral antioxidant levels related periodontal disease reduced specificity shows saliva antioxidant levels test could detect alterations predisposing periodontal disease clinically evident aspects elsevier ltd rights reserved
much unknown adult attachment style formation investigate whether negative reinforcement schedules promote hallmark features secure anxious attachment styles shock threat support seeking paradigm participants ostensibly asked help another participant seated another room time shock threat signal appeared press button indicate need help supporter could stop imminent shock reliability supporters varied supporters consistent continuous reinforcement whereas others inconsistent variable ratio reinforcement results indicated inconsistently responsive others reinforcing variable ratio schedule led heightened approach related attentional biases toward supporter measured event related potentials increased positive attachment associations supporter implicitly measured via lexical decision task negative explicit evaluations supporter
paper general synthesis procedure using signal flow graph sfg technique realize nth order allpass current transfer function current follower transconductance amplifiers cftas grounded capacitors presented proposed circuit general contains cftas grounded capacitors without needing external passive resistors also show design procedure given simple structure convenient tenability suitable integration furthermore circuit low sensitivity pspice simulation results agree well theoretical analysis also included
incidence cardiovascular disease rises dramatically age men women woman risk cardiovascular disease rises markedly onset menopause growing interest effect estrogen heart role pathophysiology diseases much less attention paid impact testosterone heart even though levels testosterone also decline age low testosterone levels linked development cardiovascular diseases knowledge receptors major sex steroid hormones including testosterone present individual cardiomyocytes suggests hormones may influence heart cellular level indeed well established male female differences intracellular release contraction isolated ventricular myocytes growing evidence suggests differences arise effects sex steroid hormones processes involved intracellular homeostasis review considers myocardial contractile function modified testosterone focus impact testosterone processes regulate handling level ventricular myocyte idea testosterone regulates handling heart important dysregulation plays key role pathogenesis variety different cardiovascular diseases better understanding sex hormone regulation myocardial homeostasis may reveal new targets treatment cardiovascular diseases older adults
calibration validation satellite observations essential going tasks ensure compliance mission accuracy requirements automated water hyperspectral radiometer significantly augmented australia ability contribute global regional ocean color validation algorithm design activities hyperspectral data sampled comparison current future sensor wavebands continuous spectral acquisition along ship track enables spatial resampling match satellite footprint study reports spectral comparisons radiometer data visible infrared imaging radiometer suite viirs moderate resolution imaging spectroradiometer modis aqua contrasting water types tropical waters northern australia based standard nir atmospheric correction implemented seadas consistent match ups shown transects range reflectance values modis viirs satellite reflectance data consistently underestimated situ spectra blue bias relative dynamic water radiance irradiance collector dalec ranging automated acquisition produced good quality data standard operating maintenance procedures sensitivity analysis explored effects assumptions data reduction methods indicating need comprehensive investigation quantification source uncertainty estimate dalec reflectances deployment research vessel provides potential radiometric data combined sampling observational activities contribute algorithm development wider bio optical research community
problem distributive electric network operation upgrading efficiency terms selecting optimum strategy maintenance components considered maintenance repair distributive network components controllable random processes description homogeneous semi markov model discrete conditions continuous time developed based complex criterion expenses reliability optimization transmission distribution equipment maintenance carried
paper presents digital hardware implementation real time simulator multiphase drive using field programmable gate array fpga device simulator developed using high speed integrated circuit hardware description language vhdl modular hierarchical design making flexible portable state space representation model suitable fpga implementation proposed dual three phase induction machine dtpim dtpim model computed fixed time step simulator also models level pulse insulated gate bipolar transistor igbt based voltage source converter vsc pulse width modulation pwm scheme measurement system real time simulation outputs stator currents rotor speed validated steady state transient conditions using reference experimental test bench based dtpim rated power results demonstrate accuracy efficiency proposed digital hardware implementation
purpose current processes manage changes subject failure since heavily dependent human discipline purpose paper evaluate quantify difference levels automation change management processes provide input determining use automation systems change management design methodology approach three generations change management processes defined represent progressive practices used major capital projects past decades discrete event simulation used model processes capture behavior compare performance according time compliance metrics oil gas megaproject served validate findings modeling analysis findings results showed automated processes bring compliance real time traceability significant time reduction change process contributes understanding impact workflow based automation construction process performance validity conclusions limited breadth sectors studied inability capture line time allocations personnel involved future research may build work presented studying additional processes requests information project change notices requests scaffolding interface management various industry sectors originality value new approach modeling evaluating construction management process automation contributed specific results paper indicate automated workflow based change management processes implemented megaprojects
paper electric induction force due time varying current used account longitudinal recoil force exerted rails railgun accelerators analysis based lorentz force law paper shows induction force longitudinal rails magnitude depends location speed acceleration armature strongest heads rails observed experiments
brain amino acid oxidase dao daao mainly oxidizes serine agonist methyl aspartate nmda receptors thus dao regulate function nmda receptors via serine breakdown furthermore dao activator daoa reported daoa repressor expression dao daoa genes proteins human brain yet elucidated aim study understand regional age span distribution dao daoa mrna protein concomitant manner determined dao daoa mrna protein expression across six brain regions normal human post mortem brain samples weeks gestation years using quantitative real time reverse transcription polymerase chain reaction enzyme linked immunosorbent assay found higher expression dao mrna cerebellum whereas lower expression dao protein cerebellum compared brain regions studied suggests post transcriptional regulation detected daoa protein daoa mrna brain regions studied suggesting tightly regulated expression understand regulation transcriptional level analyzed dna methylation levels dao daoa cpg sites cerebellum frontal cortex control human post mortem brain obtained gene expression omnibus datasets indeed dao daoa cpg sites cerebellum significantly methylated frontal cortex investigating lifespan effects found dao mrna levels positively correlated age years cerebellum amygdala also detected significant positive correlation controlled age dao daoa protein brain regions studied except frontal cortex summary dao daoa expression human brain age brain region dependent
paper presents descriptions results multi scale pullout interface shear tests woven polypropylene geotextile reinforcement material marginal quality soil main objective tests develop moisture reduction factor mrf pullout resistance equation currently available design guidelines tests carried different overburden pressure gravimetric water content gwc values differences soil geotextile interface strength among cases different gwc values used determine corresponding mrf values results study indicate reinforcement interface strength pullout resistance could decrease significantly result loss matric suction cases dry wet soil optimum moisture content concluded wetting soil geotextile interface construction service life reinforced soil structure measurably reduce interface strength pullout resistance geotextile reinforcement needs accounted design results study also useful estimate difference pullout capacity geotextile reinforcement marginal soil placed different gwc values construction methodology described paper could used expand database mrf results include wider range soil types geotextile reinforcement practical applications elsevier ltd rights reserved
pilot research revealed dielectric constant polyimide reduced modulus improved assembling necklace like interlocking complexes crown ethers find properties complex still adequately meet demand practical applications also deterioration thermal stability functional octa aminopropyl silsesquioxane oaprs significantly rigid cage incorporated crown complex produce inorganic organic oaprs nanocomposites exploiting synergetic effect oaprs properties clearly improved case oaprs dielectric constant reduced young modulus tensile strength increased respectively addition thermal stability complex modified weight loss temperature glass transition temperature increased degrees respectively incorporation wff oaprs indispensable nano reinforcing role aggregated oaprs crystal nanocomposite carefully analysed verified elsevier ltd rights reserved
radar absorbing material effective means rcs reduction context stealth technology paper present design multi layer microwave absorber fractal frequency selective surface fss embedded micro genetic algorithm employed optimization design two designs presented paper regard different frequency spectrum experimental result shown indicates reduction band reflection flat surface use configuration lossy dielectrics good agreement simulation result
background cigarette smoking important risk factor unhealthy dieting behaviors udbs youth role alternative tobacco products udb engagement yet examined empirically despite concerning trends use study aimed examine udb prevalence geographic region specific adolescent sample associations variety tobacco use behaviors perceptions methods weighted data virginia youth survey analyzed udbs assessed included past day fasting diet pill use vomiting laxative use tobacco related items ever past day cigarette smoking past day smokeless tobacco cigar use perception smokers friends udb prevalence recoded number behaviors endorsed bivariate multinomial regression models used examine associations covariates number udbs endorsed gender results overall nearly engaged least one udb fasting prevalent followed vomiting laxative diet pill use across gender ever cigarette smoking past day cigar use perception smokers friends positively associated udb engagement relative isolation well combination conclusions findings highlight importance tobacco related factors weight control behaviors first identify association udb incidence alternative tobacco product cigars work inform prevention efforts tobacco use udbs underscores need address use tobacco weight control
paper implementation pid controllers development passive rehabilitation exercises presented designed built ankle rehabilitation prototype based structure parallel robot mechanism type rrsp two closed kinematic chains consisting joints revolute revolute sphere slot fixed post sphere free software used develop computer programs associated rehabilitation exercises regarding laboratory testing stage results passive exercises reported exercises path planning included pid control used inversion eversion dorsal plantar flexion combined movements
problem existence metzler matrices given spectra addressed positive stable continuous time linear systems electrical circuits necessary sufficient conditions existence metzler matrices established shown positive stable electrical circuits real eigenvalues open problem positive electrical circuits formulated considerations illustrated numerical examples linear systems positive electrical circuits
objectives research article aims measure effects group therapy institutionalized elderly terms reducing depression improving psychosocial functioning methods thirty elderly nursing home residents recruited elected receive group treatment depression declined treatment multidimensional observation scale elderly subjects geriatric depression scale given groups group work began ended results clients received group treatment experienced reductions depression psychosocial functioning improved conclusion group work intervention followed reductions depression levels improvements psychosocial functions among institutionalized elderly clients
design nonlinear luenberger observer extended nonlinear system resulting parameterized linear siso single input single output system studied observability assumption system existence observer concluded second step novel algorithm identification system suggested compared adaptive observers available literature advantage low dimension admit strict lyapunov function
anticholinergics one mainstay medications treatment overactive bladder syndrome review assessment current literature describing cognitive adverse effects related anticholinergic medication use elderly population anticholinergic medications without adverse drug effects activity receptors multiple sites body many side effects including constipation dry mouth confusion thought self limited duration medication exposure recent studies shown association long term anticholinergic medication use increased risk irreversible cognitive changes dementia urologists aware recent studies order provide counseling anticholinergic dose minimization discontinuation anticholinergics signs cognitive decline potential risk long term cognitive effects balance immediate benefits decreasing incontinence improvements quality life
grouted connections gcs extensively used offshore applications last decades widely used today offshore monopile wind turbines effectiveness connections monopiles questioned recently several substructures reported insufficient performance wind farms europe paper brings together current practice terms engineering methods used determination loads acting structure numerical methods used investigation structural behaviour respect hydrodynamic loads monopile wind turbines popular linear wave theory along morison equation used model normal sea states whereas higher order wave models necessary investigate severe events wave breaking terms wind loads blade element momentum proves advantageous respect computational cost ease implementation simulation tools finally finite element modelling gcs introduced close attention given non linearity grout material interface contact considered decisive aspects structural analysis
appropriate health knowledge health perceptions patients spinal cord injury sci linked health related behaviors compliance involvement caregivers efficacy prophylaxis management secondary conditions significance factors determining efficacy educational interventions patients sci underestimated systematic literature review aims identification determinants among patients sci identified papers quantitative measurements conclusive identification determinants individuals sci better correlated health condition related variables traumatic sci history secondary conditions except depression body functions structures tetraplegia incomplete deficit activities independence daily living activities ability locomotion wheelchair inability walk social vocational participation environmental factors access computer internet connection living big city married healthcare recently received personal factors younger age among adults living sci longer time younger age sci onset higher educational level internal locus control limitations encountered included high nonresponse rates among patients enrolled use heterogeneous nonvalidated tools results studies cover entire scope possible interactions exclusively apply univariate correlations paucity methodological limitations studies conclusive identification determinants sci patients development new approaches information education warrant high quality research basis multivariate analyses copyright wolters kluwer health inc rights reserved
introduction mental skills training refers teaching performance enhancement stress management psychological strategies may benefit surgeons objective review application mental skills training surgery contrast domains examine effectiveness approach enhancing surgical performance reducing stress provide future directions mental skills training surgery materials methods systematic literature search medline pubmed psycinfo clinicalkey performed keywords included mental readiness mental competency mental skill mental practice imagery mental imagery mental rehearsal stress management training stress coping mental training performance enhancement surgery reviews mental skills interventions sport well regarded sport psychology textbooks also reviewed primary outcome interest effect mental skills surgical performance simulated clinical environment results identified abstracts articles met inclusion criteria reviewed majority literature provides evidence mental imagery stress management training programs effective enhancing surgical performance reducing stress studies disciplines suggest comprehensive mental skills programs may effective imagery stress management techniques alone conclusions given demonstrated efficacy mental imagery stress management training surgery incremental value comprehensive mental skills curricula used domains concerted effort made apply comprehensive mental skills curricula surgical training
challenging times cardiac surgical anesthesia team interventional cardiologist seem closed flow good cases coming surgery successful percutaneous interventions seem offering reasonable results patients therefore knock doors surgeons common experience among cardiac anesthesiologists surgeons type cases come high risk may presence comorbidities ongoing medical therapies unstable angina uncontrolled heart failure rhythm disturbances patients ischemic heart disease target coronaries far ideal several activities institution preoperative supportive circulatory ventilatory systemic disease control maneuvers seem helped improving outcome high risk patients review attempts look various interventions resulting improvement outcomes several changes happened realm cardiac surgery several route times want evidence maximal optimization may take place patient may encounter unfavorable outcomes review attempt bring focus members cardiac surgical team value preoperative optimization risks improve outcome cardiac surgical patients may broadly divided adults undergoing coronary artery bypass graft surgery valve surgery pediatric patients undergoing repair palliation congenital heart ailments optimization risks appear different genre patients review also brings less often discussed issues anemia nutritional issues endocrine problems review attempt data ameliorating modifiable risk factors altering non modifiable ones
objective paper describes new congestive heart failure chf treatment performance measure information extraction system chief developed part automated data acquisition heart failure project veterans health administration project aiming improving detection patients receiving recommended care chf design chief based apache unstructured information management architecture framework uses combination rules dictionaries machine learning methods extract left ventricular function mentions values chf medications documented reasons patient receiving medications measurements training evaluation chief based subsets reference standard various clinical notes veterans health administration patients domain experts manually annotated notes create reference standard metrics used included recall precision measure results general chief extracted chf medications high recall good precision mentions left ventricular ejection fraction also extracted high recall precision quantitative values left ventricular ejection fraction found recall high precision reasons prescribing chf medications difficult extract reaching fair accuracy recall precision conclusion study demonstrated applying natural language processing unlock rich detailed clinical information found clinical narrative text notes makes fast scalable quality improvement approaches possible eventually improvingmanagement outpatient treatment patients suffering chf
timber framed architecture owns thousands years history china however rapid industrialization urbanization timber frame houses substantially deceased order reduce concentration greenhouses gas atmosphere establish low carbon society promotion green building materials energy saving buildings put prominent place chinese government however number timber frame houses potential using timber green sustainable architectural materials still low china paper presents findings questionnaire shows chinese consumers attitudes timber frame houses semi structured questionnaire method chosen explore common consumers attitudes found prejudice regarding deficiency timber houses terms fire resistance durability stability persists minds consumers aim paper better understanding challenges difficulties timber frame houses market facing view consumers thus figure better ways future development authors published elsevier ltd open access article license
review member panel experts surgical prehabilitation addresses processes may improve oncologic care surgical prehabilitation process continuum care occurs time cancer diagnosis beginning surgical treatment panel focused current state science recommended future research would help identify elements enhance preoperative physical nutritional psychological health anticipation surgery mitigate burden disease facilitate return patient health status baseline values decrease postoperative morbidity reduce health care costs
high frequency dual buck full bridge inverter small power renewable energy applications proposed paper implementation wide band gap sic silicon carbide power device contributes high switching frequency khz high frequency contributes reduced converter volume well improved power density greatly strengthens portability application range control strategy voltage current dual loop controller employed three pole three zero compensator applied current loop order track current reference without static error voltage loop two pole two zero compensator used generate current reference stabilizing bus voltage inner current loop analyzed detail includes modeling equivalent inductor capacitor inductor lcl type inverter design compensator also outer voltage loop discussed model established based energy balance furthermore feedback linearization method adopted simplify duty cycle calculation helps accelerate control speed second order generalized integrator software phase lock loop sogi spll employed obtain phase angle synchronize inverter output current grid voltage parallel structure algorithm conducted based dual core microcontroller unit mcu first time control high frequency inverter approach avoids contradiction high frequency operation limited computing capacity conventional single core mcus software structure time consuming distribution interactive communication method analyzed detailed finally paper verifies feasibility theoretical analyses simulation experiments based prototype
global software development gsd paradigm last fifteen years shifted novel ground breaking widely adopted mainstream wide adoption partly owing many benefits provided gsd reduced labour costs proximity new markets access diverse experienced skills pool yet taking advantage benefits far straightforward research literature includes proliferation guidelines reviews models support gsd industry although active area study firmly established research area right boundaries general software engineering gsd somewhat confused poorly defined effort consolidate understanding gsd developed ontology order capture relevant terms concepts relationships related goals barriers features gsd projects study present builds research conducted collaboration project industry academia developed ontology order provide practitioners common language conceptualisation successful outcome encouraged create broader ontology captures current trends gsd literature key ontology along three subontologies result review relevant literature together several expert evaluations ontology serve useful introduction gsd researchers new paradigm moreover practitioners take advantage order contextualise projects predict detect possible barriers using common language help researchers practitioners avoid ambiguities misunderstanding elsevier rights reserved
according scientific literature childrens cognitive development complete adolescence therefore problems inherent children serving witnesses crucial preschool aged children false memories may identified misinformation insight bias additionally susceptible suggestions aim study verify levels suggestibility children three years age ninety two children examined male female years used correlation coefficient pearson averages variance spss statistical program results concluded younger children almost always susceptible suggestibility dimension immediate recall negatively correlates total suggestibility social compliance source monitoring errors contribute patterns suggestibility older children shift answers often younger children change answers times
objective explore serum caveolin cav levels patients atrial fibrillation evaluate role cav biomarker incident heart failure methods three hundred five patients enrolled study divided three groups sinus rhythm group paroxysmal group paaf persistent group peaf serum cav concentrations measured enzyme linked immunosorbent assay baseline clinical characteristics laboratory data collected hospitalization follow months carried results serum cav concentrations significantly decreased group highest concentrations cav patients found group peaf tertile studies subjects lower tertile cav concentrations likely become paroxysmal much lower lad middle upper tertiles participants tended suffer compared lower group conclusion provide evidence cav significant meaning patients levels cav may related lad new onset
circularly orthogonal moments widely used many computer vision applications unfortunately suffer two errors namely numerical integration error geometric error heavily degrade reconstruction accuracy pattern recognition performance paper describes new kind circularly orthogonal moments based chebyshev rational function unlike conventional circularly orthogonal moments defined unit disk proposed moment defined whole polar coordinates domain addition given order radial projection function smoother oscillates lower frequency compared existing circularly orthogonal moments free geometric error highly robust numerical integration error experimental results indicate proposed moments perform better image reconstruction pattern classification yield higher tolerance image noise smooth distortion comparison existing circularly orthogonal moments elsevier inc rights reserved
study carried popular tourist destination located italy short term pollution posed problem low quality status bathing waters according european directive owing fecal contamination caused drainage ditches goal understand role meteorological conditions freshwater seawater bacterial indicator levels impact polluted streams seawater contamination aim results surface waters analyzed five bathing seasons results demonstrated relationship bacterial densities rainfall amount time dependent dilution effect sea two halves bathing season analytical survey confirmed strategic role meteorological variables bathing waters quality could support generation development predicting models indicator levels bathing area elsevier ltd rights reserved
background ovarian tumours leading cause death ghana even though geographical racial differences exist frequency types age distribution primary ovarian tumours information clinical pathological characteristics ovarian tumours ghana neighboring countries scanty determined frequency age distribution histopathological types clinical features primary ovarian tumours diagnosed korle teaching hospital ghana aid management patients method pathology records ovarian tumours diagnosed january december reviewed histopathologically tumours classified according world health organization classification biographical clinical data patients also collected entered epi info determine frequency age distribution clinical features types ovarian tumour results seven hundred six ovarian tumours studied germ cell tumours common mean age occurrence years dominated mature teratomas surface epithelial tumours second commonly occurred women aged years sex cord stromal tumours followed mean age occurrence years common malignant tumours surface epithelial dominated serous carcinomas mean age years patients presented within month onset symptoms feeling lower abdominal mass conclusion common primary ovarian tumours study germ cell tumours dominated mature teratomas adenocarcinomas mostly serous occur younger women compared findings western studies single common malignant ovarian tumour children adolescents burkitt lymphoma patients develop ovarian tumours specific symptoms signs presentation aid early diagnosis
paper proposes estimating method operating temperature flux density magnet permanent magnet synchronous motor pmsm load condition method based combination motor differential equations thermal equivalent circuit magnetic equivalent circuit paper effectiveness proposed method verified comparing calculated result finite element analysis fea also effectiveness confirmed experimental result
objectivethere interest whether people attention deficit hyperactivity disorder adhd higher risk developing eating disorder aim study estimate size association meta analysis studies methodswe retrieved studies following prisma guidelines broad range databases resultstwelve studies fitted primary aim investigating adhd populations adhd controls five exploring adhd populations controls pooled odds ratio diagnosing adhd increased significantly similar level risk found across syndromes anorexia nervosa bulimia nervosa binge eating disorder risk significantly higher adhd diagnosed using clinical interview rather self report instrument pooled odds ratio diagnosing adhd participants significantly increased subgroup analysis cohorts binge eating yielded risk none variables examined meta regression procedures explained variance effect size studies discussionpeople adhd higher risk comorbidity people also higher levels comorbidity adhd future studies address patients comorbidity different prognosis course treatment response compared patients either disorder alone resumen objetivoha habido interes saber gente con trastorno por deficit atencion hiperactividad tdah estan mayor riesgo desarrollar trastorno conducta alimentaria tca objetivo este estudio fue estimar tamano esta asociacion con meta analisis los estudios metodos recuperamos estudios una amplia gama base datos que siguen los lineamientos prisma resultados doce estudios encajaron con nuestro objetivo primario investigar los tca poblaciones con tdah tdah controles exploraron tdah poblaciones con tca tca controles odds ratio agrupado diagnosticar cualquier tca tdah incremento significativamente nivel riesgo similar fue encontrado todos los sindromes tca anorexia nervosa bulimia nervosa trastorno por atracon riesgo fue significativamente mayor tdah fue diagnosticado utilizando una entrevista clinica lugar instrumento auto reporte odds ratio agrupado diagnosticar tdah participantes con tca fue significativamente incrementado analisis los subgrupos cohort con atracones solamente produjo riesgo ninguna las variables examinadas los procedimientos meta regresion explicaron varianza tamano del efecto entre los estudios discusion gente con tdah tiene mayor riesgo comorbilidad con tca gente con tca tambien tiene niveles altos comorbilidad con tdah los estudios futuros deberan abordar los pacientes con esta comorbilidad tienen diferente pronostico curso respuesta tratamiento cuando son comparados con pacientes que solamente tienen uno los trastornos wiley periodicals inc int eat disord wiley periodicals inc int eat disord
cognitive robots started find way manufacturing halls however full potential robots exploited integration automation pyramid system able communicate manufacturing execution system mes integrating robot mes allows robot get access manufacturing environment process data perform task without human intervention paper describe mobile robotic manipulator developed project stamina integrated existing mes application kitting task automotive industry
four aromatic pyrrolidinyl benzodioxane epimer dioxane stereocenter previously reported alpha beta nachr ligands replaced nitrogen resulting four diastereoisomeric pairs pyrrolidinyl pyridodioxanes studied nicotinic affinity activity alpha beta alpha beta alpha nachr subtypes compared common carbaisostere turned isosteric substitutions highly detrimental important exception stereoisomer pyrrolidinyl pyridodioxane pyridine nitrogen adjacent dioxane seven atoms distant pyrrolidine nitrogen indeed stereo regioisomer maintained alpha beta affinity also greatly improved selectivity alpha beta alpha subtypes importantly exhibited highly selective alpha beta partial agonism finding instead unselective alpha beta antagonist indicates benzodioxane substructure confers affinity alpha beta nachr binding site activation receptor subtype needs benzodioxane functionalization strict steric requirements previously reported substitution present isosteric modification elsevier masson sas rights reserved
investigated effects ethyl fluorobenzyl methyl oxo dihydropyridine carbonyl amino cyclohexanecarboxylic acid novel cannabinoid type receptor agonist fluoro dinitrobenzene dnfb induced ear inflammation mite antigen induced dermatitis mice oral administration significantly suppressed dnfb induced ear swelling dose dependent manner addition significantly alleviated mite antigen induced atopic dermatitis like skin lesions nga mice histological analysis revealed significantly reduced epidermal thickness number mast cells infiltrating skin lesions demonstrated inhibited mite antigen induced eosinophil accumulation skin lesions endogenous ligand arachidonoylglycerol induced eosinophil migration vitro moreover confirmed levels significantly increased skin lesions mite antigen induced dermatitis model together results suggest inhibits skin inflammation mice blocking activities karger basel
changing trends globalization given rise various challenges software industry today repute software engineering related quality timely delivery product repute also depends industry keeps pace new expertise changing market situation factors like transparency recognition work life balance etc play imperative part preserving reasonable edge ism methodology interactive learning process method factors affect system directly indirectly outlined complete structure model major advantage ism model graphical representations identified factors structured manner indeed subject consideration tool organizes elements affecting system credibility also highlights hierarchical complexity among factors system ultimate necessity analyze performance factors operative application execution software development process main objective paper identify shared communication factors identify driving dependent factors work ism model prepared recognize significant factors administrative consequences software release time point view
failure homogeneous devices due reason called homogeneous fault networks contrast heterogeneous platforms deployed simultaneously network robust homogeneous faults one challenging problems design survivable networks homogeneous faults paper utilizes edge colored graphs investigate network topology homogeneous faults order guarantee network connectivity using minimum number links two types network topologies proposed edge colored graph one type networks characterized fact edges color form hamiltonian path hamiltonian cycle upper bound number colors used proposed network topologies obtained network topologies second type edges colored five colors additionally subnetworks induced edges two colors contain hamiltonian path hamilton cycle cases
maximum operational range continuous variable quantum key distribution protocols shown improved employing high efficiency forward error correction codes typically secret key rate model protocols modified account non zero word error rate codes paper demonstrate model incorrect firstly show example fixed rate error correction codes currently defined exhibit efficiencies greater unity secondly show using secret key model combined greater unity efficiency codes implies possible achieve positive secret key entanglement breaking channel impossible scenario consider secret key model post selection perspective examine implications key rate constrain forward error correction codes operate low word error rates
qatar dabigatran introduced followed rivaroxaban study aim explore trends oral anticoagulant use qatar past years extent doacs replace warfarin also explored extent switching different anticoagulants warfarin doacs vice versa collected anticoagulant prescriptions dispensed patient hamad medical corporation hmc hospitals overall number patients using warfarin dabigatran rivaroxaban last years collectively calculated per calendar year calculated number oac used warfarin dabigatran rivaroxaban frequency use one oac prescribed compared change proportion doacs warfarin prescriptions years overall patients using oac past years among used warfarin used dabigatran used rivaroxaban oral anticoagulants use increased gradually number patients receiving doacs increased significantly compared warfarin since introduction number rivaroxaban users increased significantly compared dabigatran doacs gradually replacing warfarin qatar trend use similar reported countries warfarin remains commonly used oral anticoagulant
countrywide lack relevant necessary professional tertiary institutions offering education training green building south africa causes lack awareness knowledge skill green building principles directly results lack introduction implementation thereof projects property development industry purpose study determine whether tertiary institutions started incorporate green building programmes modules current curricula literature review green building education academic institutions also property industry educators done develop questionnaire reflecting status quo green building education programmes built environment departments six south african universities departments included quantity surveying construction management architecture quantity surveying construction management urban planning intention article investigate curriculum renewal innovation merely examine status quo green building education currently offered tertiary professional institutions south africa based findings green building education built environment departments academic institutions south africa lagging behind progress seems slow however signs indicating positive changes made introduce implement green building education
aim argirein rhein arginine derivative rhein isolated chinese rhubarb rheum officinale baill exhibits antioxidant anti inflammatory activities present study investigated effects argirein stress induced hypergonadotrophic diabetic hypogonadotrophic hypogonadism male rats methods stress induced diabetic hypogonadism induced male rats via injection isoproterenol iso streptozotocin stz iso injected rats treated argirein testosterone replacement days stz injected rats treated argirein aminoguanidine weeks rats euthanized blood samples testes collected serum hormone levels measured expression endothelin receptor eta connexin proteins testes detected vitro experiments testis homogenate prepared normal male rats incubated iso mol high glucose mmol results iso injection induced hyper gonadotrophic hypogonadism characterized low testosterone high fsh levels serum whereas stz injection induced hypogonadotrophic hypogonadism evidenced low testosterone low fsh levels serum testes iso stz injected rats expression eta mmp nadph oxidase ppkcc significantly increased expression decreased administration argirein attenuated abnormal serum hormone levels testis changes iso stz injected rats aminoguanidine produced similar actions stz injected rats testosterone replacement reversed abnormal serum hormone levels affect testis changes iso injected rats argirein pmol exerted similar effects testis homogenate incubated iso high glucose vitro conclusion two types hypogonadism male rats exhibit increased expression eta depressed expression testes despite different patterns serum fsh argirein alleviates two types male hypogonadism via normalizing eta testes
mentoring extremely valuable activity individuals organizations mentoring within organizations develop integrate employees corporate culture mentoring outside thementees work groups professional development organizations give broader perspective support especially times transition mentoring programs require tremendous effort start organize maintain last two years article provides structured approach starting sustaining successful program steps include understanding organization particular needs learning small pilot programs following mentoring pairs committed formal mentoring period evaluating results program cycle learn grow program supplementary materials article available online
purpose study assess polysomnographic indicators increased mortality risk patients stroke transient ischemic attack tia performed polysomnographies acute stroke tia patients mortality data collected national database month follow period stroke tia patients stroke patients died follow nine moderate severe sleep related breathing disorders srbds binarily divided group highest apnea hypopnea index ahi almost fold higher mortality risk hazard ratio confidence interval compared patients lowest ahi patients longest versus shortest nocturnal wake time higher mortality lung disease increased mortality trend toward higher mortality risk atrial fibrillation flutter stroke patients ahi nocturnal wake time indicators increased mortality risk srbds stroke patients receive increased attention
hypothyroidism common condition hormone deficiency oral administration thyroid hormones currently available treatment option however disadvantages treatment modality including compliance challenges patients therefore physiologically based alternative therapy hypothyroidism little side effects needed study developed method microencapsulating porcine thyroid cells thyroid hormone replacement approach hybrid wall polymer microcapsules permits thyroid hormone release preventing immunoglobulin antibodies entry strategy could potentially enable implantation microcapsule organoids containing allogeneic xenogeneic thyroid cells secret hormones time without need immunosuppression recipients porcine thyroid cells isolated encapsulated alginate poly ornithine alginate microcapsules using microfluidic device porcine thyroid cells formed three dimensional follicular spheres microcapsules decent cell viability proliferation thyroxine release encapsulated cells higher unencapsulated cells days results suggest microencapsulated thyroid cell organoids may potential used therapy drug screening
natural cellulosic fibres flax fibres present interesting mechanical properties well biodegradability products short flax fibres could used produce geotextiles stabilise soils today geotextiles often made coir fibres high lignin percentage leading slow degradation soil fibres high cellulosic content flax exhibit lower resistance soil degradation study investigates solutions improve parameter view increasing service life therefore credibility compared coir fibres geotextile applications purpose cellulose coating yarns made short flax fibres performed stability water flow assessed ability form cellulose sheath estimated chromaticity measurements flax fibres applying dye specific lignin infrared spectrometry analysis monitor level protection degradation cellulolytic enzymes also carried appears cellulose coating provides efficient physical protection preventing access enzymes fibrous substrate possibility conferring antibacterial properties cellulose coating chelating phytoalexin molecules gramine assayed proven effective soil cellulolytic bacteria cellvibrio fulvus cellvibrio vulgaris study therefore establishes coating flax yarns cellulose associated antibacterial molecules could contribute obtaining longer service life soil geotextiles manufactured flax fibres elsevier ltd rights reserved
fuzzy trace theory posits independent verbatim gist memory processes distinction implications applied topics eyewitness testimony distinction precise literal verbatim memory meaning based intuitive gist accounts memory paradoxes including dissociations true false memory false memories outlasting true memories developmental increases false memory provide overview fuzzy trace theory using mathematical modeling also present results demonstrating verbatim gist memory true false recognition narrative sentences inferences results supported fuzzy trace theory dual process view memory verbatim memory relied reject meaning consistent unpresented sentences via recollection rejection however verbatim memory often retrieved gist memory supported acceptance sentences via similarity judgment phantom recollection thus mathematical models words extended explain memory complex stimuli narratives kind memory interrogated law society applied research memory cognition published elsevier inc rights reserved
advent network functions virtualization nfv revolutionized numerous network based applications due several benefits flexibility manageability scalability security software based virtualization network functions single infrastructure nfv provides users framework dynamically provisions various network services flexible manner however nfv faces several security challenges multi tenancy live migration make vulnerable cybersecurity attacks side channel attacks shared resource misuse attacks paper provide overview nfv discuss potentially serious security threats nfv introduce effective countermeasures mitigate threats finally suggest practical solutions provide trustworthy platform nfv elsevier rights reserved
background friendships people without intellectual disability remain elusive little known factors support development friendships services promote likelihood contact develop friendship method case study approach used explore qualities development long term friendship women severe intellectual disability qualitative methods data collection analysis used including interviews field notes participant observation findings relationship progressed stages introduction consolidation autonomy supported working practices culture disability support organisation individualised activity role connector culture positive expectations underpinned growth friendship conclusions friendships happen chance require thought attention dedicated resources commitment long term outcomes achieved
paper proposed new approach detection faults linear analog vlsi circuits approach simple efficient based signal flow graph approach also used calculate tolerance component important parameter vlsi circuit paper describe whole method testing linear analog vlsi circuits approach tested two analog circuits integrator circuit mimo circuit model calculation approach done help matlab simulink tool
purpose scoping review identify promising factors underpin effective health promotion collaborations measurement approaches evaluation practices measurement approaches evaluation practices employed english language articles published january october considered data extraction included research design health focus collaboration factors evaluated factors conceptualized measured outcome measures studies methodologically diverse employing either quantitative methods mixed methods qualitative methods total studies examined factors measured leadership commonly studied factor conceptualized differently across studies six factors significantly associated outcome measures across studies leadership gender trust length collaboration budget changes organizational model since factors often conceptualized differently drawing conclusions impact collaborative functioning remains difficult use reliable validated tools would strengthen evaluation health promotion collaborations would support enhance effectiveness collaboration authors published elsevier ltd
paper design aspects high speed electrical machines discussed analytical calculations dealing issues volume weight presented furthermore machine design parameters analyzed main target design turbo generator usage aircraft improve reliability six phase electrical machine introduced
resistance thyrotropin tsh rtsh defined elevated tsh normal hypoplastic thyroid gland caused mutations genes encoding tsh receptor pax linked locus chromosome two nonconsanguineous families nongoitrous euthyroid hyperthyrotropinemia typical rtsh phenotype exome analysis identified five rare duox gene variants sfsx found pathogenic form nongoitrous dyshormonogenesis masquerades clinically biochemically rtsh accordingly mutations duox added slca causes rtsh
green buildings designed low environmental impacts improved occupant health well improvements built environment including ventilation lighting materials resulted improved indoor environmental quality ieq green buildings evidence around occupant health currently centered around environmental perceptions self reported health investigate objective impact green buildings health tracked ieq self reported health heart rate participants green conventional buildings two weeks participants selected relocated syracuse center excellence leed platinum building six workdays ventilation volatile organic compound voc levels changed different days match ieq conventional green green green increased ventilation buildings participants reported improved air quality odors thermal comfort ergonomics noise lighting fewer health symptoms green buildings prior relocation relocation participants consistently reported fewer symptoms green building conditions compared conventional one yet symptom counts closely associated environmental perceptions measured ieq average participants times odds reporting lack air movement symptoms value bpm higher heart rate value ppm increase indoor concentration findings suggest occupant health green conventional buildings driven environmental perceptions physiological pathways authors published elsevier ltd open access article license http creativecommons org licenses
background objectives multiple sclerosis chronic progressive inflammatory disease central nervous system representing primary cause non traumatic disability young adults cognitive dysfunction affect patients time disease process might alter six core functional domains social cognition multi component construct includes theory mind empathy social perception emotions facial bodily vocal cues deficits cognitive faculty might drastic impact interpersonal relationships quality life qol although exhaustive data exist non social cognitive functions little attention paid social cognition objectives present work reappraise definition anatomy social cognition evaluate integrity domain across studies put special emphasis neuropsychological neuroimaging studies concerning social cognitive performance methods studies selected conformity prisma guidelines looked computerized databases pubmed medline scopus index peer reviewed journals identify published reports english french languages mention social cognition multiple sclerosis regardless publication year combined keywords follows facial emotion facial expression emotional facial expressions theory mind social cognition empathy affective prosody multiple sclerosis mri functional mri positron emission tomography functional imaging structural imaging also scanned references articles aiming get additional relevant studies results total studies matched abovementioned criteria neuropsychological studies including five neuroimaging studies available data support presence social cognitive deficits even early stages increase disease burden along multiple disconnection syndrome resulting gray white matters pathology might exceed threshold cerebral tolerance manifest deficits social cognition admitting impact latter patients social functioning thorough screening deficits crucial improving patients qol
student dropout rate universities fascinating especially among students electrical engineering even developed european countries face dropout rate engineering students first year rate high engineering disciplines problem calls attention educators university administration take measures help reduction dropout rate assist students successfully completing degree among many solutions control student dropout rate one adoption prediction mechanism whereby students warned potentially poor performance improve performance resulting better grades existing prediction mechanisms apply various machine learning techniques student cognitive features addition non cognitive features also significant impact students performance however sparsely applied prediction research aims improving existing prediction mechanism exploiting cognitive non cognitive features students predicting results found result analysis addition cognitive features increases prediction accuracies decision tree however addition play significant role techniques study also identified individual cognitive features considered students universities cater drop outs
aims objective work determine whether known strains nonpathogenic vibrios act probiotics control vibrio infections pacific white shrimp litopenaeus vannamei methods results ten species tested vibrio alginolyticus ncimb vibrio gazogenes ncimb showed antagonistic activity towards panel shrimp pathogenic vibrios case alginolyticus activity depended presence live bacteria gazogenes live dead bacteria showed anti vibrio activity injection shrimp either alginolyticus gazogenes total bacteria per shrimp resulted mortality higher levels case alginolyticus mortality postinjection bacteria juvenile shrimp fed commercial diets top coated either chitin immune stimulant chitin gazogenes chitin gazogenes caused significant decline number vibrio like bacteria fore hind gut changes also seen hepatosomatic index measure digestive health total number blood cells circulation analysis mid hindgut faecal samples obtained using terminal restriction fragment length polymorphism showed gut microbiota shrimp limited bacterial diversity weeks exposure experimental diets significant changes microbial flora tract shrimp result presence gazogenes conclusions vibrios tested gazogenes potential probiotic control bacterial diseases shrimp significance impact study overall study shows promise gazogenes together chitin improve health welfare shrimp aquaculture conditions
digital low dropout regulator ldo manages operate low voltage scale process tradeoff current efficiency transient response speed limits applications work coarse fine tuning technique burst mode operation employed advance trade output voltage overshoot detected power mos array changes unit size mhz sampling frequency fixed time comparing size mhz steady state limit cycle oscillation lco steady state reduced feed forward compensation zero negligible power area overheads proposed ldo simulated cmos process achieving voltage undershoot fom speed quiescent current mode lco steady state
parkinson disease debilitating neurodegenerative disorder pathologically characterized intracellular inclusions comprised primarily alpha synuclein alpha syn also transmitted neuron neuron several lines evidence suggest inclusions cause neurodegeneration thus exploring strategies improve neuronal survival neurons alpha syn aggregates critical previously exposure alpha syn pre formed fibrils pffs shown induce aggregation endogenous alpha syn resulting cell death exacerbated either starvation inhibition mtor rapamycin able induce autophagy intracellular protein degradation pathway since mtor inhibition may also inhibit protein synthesis starvation detrimental neuronal survival investigated effects autophagy induction neurons alpha syn inclusions starvation mtor independent autophagy induction mechanism exposed mouse primary cortical neurons pffs induce inclusion formation presence absence disaccharide trehalose proposed induce autophagy stimulate lysosomal biogenesis expected observed exposure pffs increased abundance alpha syn aggregates cell death trehalose alone increased levels consistent increased autophagosome levels remained elevated pff exposure interestingly trehalose alone increased cell viability time course trehalose also able restore cell viability control levels pffs still exhibited toxic effects cells data provide essential information regarding effects trehalose asyn accumulation neuronal survival exposure pff
recently early diagnosis squamous cell carcinoma antigen scca tumor maker various cancers increasingly attracted lot attention heightening incidence rate cancer scca low concentration human serum diluted detecting thus immunoassay high sensitivity significant early detecting scca therefore nonenzymatic sandwich type electrochemical immunosensor herein conducted quantitative detection squamous cell carcinoma antigen scca amino functionalized cobaltosic oxide ceric dioxide nanocubes core shell morphology prepared combine sea urchin like gold platinum nanoparticles coo ceo used labels conjugate secondary antibodies signal amplification due synergetic effect excellent electrochemical property superior auxiliary catalytic activity coo ceo high electrocatalytic current responses toward reduction hydrogen peroxide achieved besides electrodeposited gold nanoparticles nps modified glassy carbon electrodes gce used antibodies carriers sensing platforms well cooperation coo ceo nps broad linear range low detection limit detecting scca achieved addition immunosensor displayed good reproducibility high selectivity stability results satisfactory proposed method applied analyze human serum samples indicating potential application promising clinical monitoring tumor markers
work present polyblaze scalable configurable multicore platform fpga based embedded systems systems research polyblaze extension microblaze soft processor leveraging configurability microblaze bringing multicore era linux symmetric multi processor smp support work details hardware modifications required microblaze processor software stack enable fully validated smp operations including atomic operation support shared interrupts timers exception handling new work present scalable flexible memory hierarchy optimized field programmable gate arrays fpgas manages atomic operations provides support future flexible memory hierarchies heterogeneous systems also new depth analysis key performance characteristics including memory bandwidth latency resource usage system configurations bandwidth found scale linearly addition processor cores memory interface saturated additionally average memory latency remains constant memory interface saturated scales linearly additional processor core categories subject descriptors computer system implementation microcomputers operating systems general performance reliability general
introduction chronic rhinosinusitis crs common disease upper airways paranasal sinuses marked decline quality life qol crs patients suffer sleep disruption significantly higher proportion general population sleep disruption crs causes decreased qol linked poor functional outcomes impaired cognitive function depression areas covered systematic pubmed medline search done assess results studies investigated sleep sleep disturbances crs expert commentary studies reported sleep disruption crs patients main risk factors sleep disruption crs include allergic rhinitis smoking high snot total scores literature inconsistent regard prevalence sleep related disordered breathing obstructive sleep apnea crs patients although nasal obstruction linked sleep disruption extent sleep disruption crs seems expand beyond expected physical blockage upper airways alone despite high prevalence sleep disruption crs detrimental effects qol literature contains paucity studies investigated mechanisms underlying major problem crs
information becoming first class citizen internet information centric networking icn considered promising direction future internet named data networking ndn prominent example emerging icn architectures unfortunately ndn vulnerable various attacks targeting network caching mechanism paper focus false locality pollution attack adversary repeatedly requests number unpopular data objects waste precious cache space ndn router reduce normal users hit ratios simulation experiments show attack cause considerable damage ndn network detect mitigate attack introduce algorithm exploits diversity interest traversing paths within internet service provider point presence network also propose inexpensive methodologies based probabilistic counting bloom filter techniques implement algorithm ndn router experimental results indicate proposed algorithm effective thwarting false locality pollution also experiment strategies adversary may utilize antipollution algorithm demonstrate strategies either ineffective impractical real world
background united states preventive services task force recommends universal osteoporosis screening among women ages targeted screening younger women historically adherence evidence based recommendations suboptimal methods describe contemporary patterns osteoporosis screening conducted retrospective analysis using optumlabs data warehouse database identifiedadministrative claims includes medical eligibility information million medicare advantage commercial enrollees study participants included women ages prior history osteoporosis diagnosis osteoporosis drug use hip fracture osteoporosis screening recent year period continuous enrollment assessed via medical claims patient sociodemographics comorbidities utilization services also determined using health insurance files results overall screening rates low among women ages years respectively secular trends differed significantly age utilization among women ages years declined changed little among women increased among women years even accounting socioeconomic status health status health care utilization patterns non hispanic black women least likely screened whereas non hispanic asian hispanic women likely undergo screening marked socioeconomic gradients screening probabilities narrowed substantially time decreasing among women ages years respectively conclusions despite significant changes utilization osteoporosis screening among women ages line national recommendations tremendous deficiencies among women remain authors published elsevier inc
high rates persistent symptoms found following cholecystectomy patients gallstones aim population based cohort study determine symptoms associated development clinical gallstone events population unaware gallstones three random population samples copenhagen examined ultrasound participants informed gallstone status abdominal symptoms assessed baseline questionnaire follow clinical events performed central registers multivariable cox regression analyses performed participants unaware gallstones followed median years total participants developed clinical events uncomplicated complicated events associated high pain intensity baseline complicated events also associated pain night uncomplicated events associated pain localized epigastrium longer duration need pain medication associations identified dyspepsia irritable bowel syndrome population unaware gallstone carriers possible identify abdominal symptoms associated later clinical detection gallstones finding may contribute better selection patients surgery
polypharmacy come mean inappropriate use multiple medications polypharmacy occur result range situations including excessive application clinical guidelines lack coordination among multiple prescribers treating adverse drug events misaligned medications across transitions care patient self treatment inappropriate overtreatment polypharmacy problem benefits specific medication dose frequency individual patient taking often outweighed costs costs financial however may place greater burden lead unrealized benefits adverse clinical effects
introduction psoriasis chronic immunomediated inflammatory disease involving mainly skin joints often associated several metabolic non metabolic comorbidities tnf alpha inhibitors shown long term efficacy safety tolerability psoriasis preliminary data support use certolizumab pegol czp well areas covered authors review pharmacological properties czp well safety data efficacy profile also review quality life outcomes related czp psoriasis authors also provide expert opinion subject expert opinion czp promising treatment psoriasis owing rapid reduction disease activity long term therapeutic efficacy bio naive non bio naive patients long term safety low rate site injection reactions czp seems promising therapeutic option psoriasis patients although evidence supporting continuing clinical program development czp psoriasis needed
legendre orthogonal functions employed design family pid controllers variety plants proposed method pid controller plant model represented corresponding legendre series matching first three terms legendre series loop gain desired one gives pid controller parameters closed loop system stability conditions terms legendre basis function pole lambda wide range systems including first order second order double integrator first order plus dead time first order unstable plants obtained first order double integrator plants closed loop system stability preserved values lambda plants appropriate range terms lambda obtained optimum value lambda attain minimum integral square error performance index presence control signal constraints achieved numerical simulations demonstrate benefits legendre based pid controller
framework scout project recover subsystem enables satellite infrastructure specifically ground control segment traffic control capabilities basically recover applies rules forward drop route traffic flows paper discuss preliminary architecture recover subsystem design based sdn novel approach computer networking allows network administrators manage network services abstraction higher level functionalities core subsystem new traffic control application provides policy based secure routing ability take routing decisions driven physical network security targets
evidence neural mechanisms underlying internet gaming disorder igd resemble drug addiction functional magnetic resonance imaging fmri studies resting state measures gray matter volume shown internet game playing associated changes brain regions responsible attention control impulse control motor function emotional regulation sensory motor coordination furthermore internet game playing associated lower white matter density brain regions involved decision making behavioral inhibition emotional regulation videogame playing involved changes reward inhibitory mechanisms loss control structural brain imaging studies showed alterations volume ventral striatum important part brain reward mechanisms finally videogame playing associated dopamine release similar magnitude drugs abuse lower dopamine transporter dopamine receptor occupancy indicating sub sensitivity dopamine reward mechanisms elsevier ltd rights reserved
article presents analyzes implementation risk sensitive particle filtering algorithm volatility estimation continuously compounded returns financial assets proposed approach uses stochastic state space representation evolution dynamic system unobserved generalized autoregressive conditional heteroskedasticity ugarch model inverse gamma distribution risk functional importance density distribution ensure allocation particles regions state space associated sudden changes volatility system set hoc performance entropy based measures used compare performance scheme respect classic implementation sequential monte carlo methods terms accuracy precision resulting volatility estimates considering purpose data sets generated blind test format garch structures time varying parameters
study carried examine whether psychological capital conceptual analysis sub dimensions hope self efficacy durability optimism existed akhism organization application founded kayseri anatolia years ago aim article emphasize key importance psyhological capital creating organizational success competitive advantage present draw attention similarities applications time akhism organization regarding development psychological capital context study includes exminations concerning possibility akhism organization source guide present businesses development share psychological capital
background hypothesized constitutionally narrow cavernous sinus might predispose individuals cluster headache cavernous sinus dimensions however never assessed methods case control study measured dimensions cavernous sinus skull base internal carotid pituitary gland high resolution weighted magnetic resonance imaging episodic chronic probable cluster headache patients chronic paroxysmal hemicrania patients headache free controls dimensions compared groups correcting age sex transcranial diameter results qualitative inspection relevant pathology anatomic variants previously associated cluster headache chronic paroxysmal hemicranias observed cavernous sinus paracavernous structures left right transcranial diameter temporal fossa level mean larger headache groups episodic cluster headache chronic cluster headache probable cluster headache chronic paroxysmal hemicrania compared controls adjusting transcranial diameter correcting multiple comparisons differences dimensions cavernous sinus surrounding structures headache patients controls conclusion patients cluster headache chronic paroxysmal hemicrania wider skulls headache free controls proportional dimensions cavernous sinus similar
paediatric palliative care ppc parents confronted increasing caregiving demands children cared home need ppc children lengthened due technical medical improvements therefore clear understanding content parental caregiving ppc becomes increasingly important objective gain insight parental caregiving based lived experience parents child life limiting disease interpretative qualitative study using thematic analysis performed single repeated interviews undertaken parents children malignant non malignant disease receiving ppc based ambition good parent parents caring child life limiting disease strived three aims controlled symptoms controlled disease life worth living ill child family balance aims resulted four tasks parents performed providing basic complex care organising good quality care treatment making sound decisions managing risks organising good family life conclusion parents need early explanation professionals balancing aims related tasks get grip situation prevent becoming overburdened
estrogens trigeminal system inherently linked prescribers treating woman hormonally related mood disorder migraine headaches consider hormonal options optimize patient treatment article discusses interrelationships estrogen serotonin trigeminal system relate menstrual migraine occurrence hormone related mood symptoms addition clinical examples provided facilitate prescribers treating women reproductive transitions declining estrogens related suffering
wadi rayan located african sahara ecoregion palearctic eco zone world largest hot desert total area wadi rayan objective present study enrich knowledge vegetation cover along shores wadi rayan lakes identify different threats underlying causes recommended solutions conservation natural vegetation cover wadi rayan protected area wrpa based field surveys found current pressures human activities natural vegetation include overgrazing irresponsible tourism land encroachment water pollution water use fire habitat change destruction reduction water levels due decreased water incoming considered main threat facing ecosystems biodiversity lakes area found perimeter lower lake decreased loss total lake area due lake decreased water level underlying causes vegetation loss study area found lack awareness weak law enforcement lack suitable strategies weak financial support lack stakeholders cooperation survey results show vegetation cover area connecting channel northeastern lower lake represents highest impacted area human pressures compared locations moreover role wrpa important achieving good cooperation governmental authorities local community owners different economic activities finding new ways improve potential future cooperation stakeholders also provide suggested activities conserving vegetation cover wrpa
since horse highly precocial reproductive strategy organs functionally well developed birth thus embryonic fetal life interesting data development important organs limited detailed macroscopically histologically equine digestive system focusing first third gestation days oral cavity empty space liver contained proliferating endodermal cells days fusiform stomach pancreatic bud present days small tongue esophagus occurred days primary secondary palates developed liver contained cords hepatocytes pancreas triangular days crypts formed intestinal loops cell differentiation observed hepatic parenchyma pancreas elongated pancreatic acini islets observed fetuses days intestines highly convoluted three segments pharynx distinguishable days days intestinal villi wide round tips especially liver stomach oral cavity showed key steps anatomical cellular differentiation early fetuses whereas areas pancreas pharynx still immature investigated phase pluripotency analysis using oct showed initial intense staining digestive system tissues later decreased becoming restricted specific cell layers conclusion data may contribute perform chronological reference developmental events approaches predicting pregnancy disorders horses wiley periodicals inc
hepatitis virus hcv infection represents world health problem protective vaccine effective drug currently exists economic reasons many patients use traditional medicines control infection egypt camel milk one traditional medicines widely consumed patients infected hcv present study aimed evaluate efficacy camel milk treatment patients infected hcv whole camel milk local farm administered patients months day patient patient sera collected prior following camel milk drinking three markers set sera evaluation three markers indicating effect camel milk hcv infection liver function assays alanine aminotransferase alt aspartate aminotransferase ast viral load assay anti hcv antibodies profile isotyping synthetic hcv epitopes camel milk demonstrated ability improve general fatigue health liver function alt ast levels alt reduced similar patients ast reduced patients subsequent drinking camel milk four months majority patients responded positively camel milk treatment rna viral load decreased patients one patient exhibited undetected viremia following camel milk treatment anti hcv antibodies profile isotyping significantly decreased immunoglobulin following treatment patients however treatment ineffective patients experienced reduction rna viral load following treatment camel milk conclusion whole camel milk treatment demonstrated efficacy vivo viral load majority patient sera reduced igg isotype profile converted immunity
introduction patients non small cell lung cancer nsclc interstitial lung disease ild high risk acute exacerbation ild ild treated systemic chemotherapy standard treatment nsclc complicated ild established purpose methods examine whether type ild categorized official ats ers jrs alat statement idiopathic pulmonary fibrosis ipf high resolution computed tomography hrct could predict chemotherapy induced ild nsclc patients ild retrospectively reviewed patients nsclc complicated ild received chemotherapy institute january december patients characteristics pathology clinical staging lung cancer chemotherapy type ild ild chemotherapy evaluated ild classified according statement follows usual interstitial pneumonia uip possible uip inconsistent uip pattern results total patients pre existing ild received chemotherapy mean age years range years fifteen patients ild developed chemotherapy induced ild seen frequently patients ild uip pattern possible uip pattern patients pattern inconsistent uip versus multivariate analyses including age sex performance status radiographic patterns ild showed presence uip possible uip pattern independent risk factor chemotherapy induced ild conclusions ild uip pattern possible uip pattern classification could risk factor ild nsclc patients ild
tonne trailer travelled across tamar suspension bridge october authors monitored response structure load following investigation documents deflection towers deck vehicle passage well change cable tensions achieved studying monitored data bridge collected accelerometers strain gauges attached stay cables well two robotic total stations measured deflection mid span sway tower saddle results subsequently compared response predicted finite element model bridge indicating accurate match model also used simulate variation dynamic response structure suggests natural frequencies vary depending vehicle location mode shape anti nodes
child sexual exploitation cse received considerable attention last years evidence pointing increased risk young people learning disabilities however study specifically focused little known best protect identify support group paper based study examined identification support sexual exploited young people learning disabilities data collection included surveys local authorities sample services supporting vulnerable disabled children depth interviews professional stakeholders young people learning disabilities risk experienced cse paper provides overview study identifies areas improvement policy practice including need education training awareness raising amongst young people families professionals tackling social isolation disempowerment invisibility young people learning disabilities need full implementation government guidance spotlight group young people elsevier ltd rights reserved
research examined children family court advisory support service cafcass reports prepared private family court proceedings domestic violence cases england research found cases children accounts identified victims violence disclosures regularly disappeared report recommendations particular discourses regarding child welfare contact identified routinely impacted ways children voices taken account whilst culturally undoubtedly influential move towards including children perspectives decision making affects views interpreted represented subject adult gate keeping powerful cultural professional ideologies regarding child welfare post separation family relationships research found unrelenting influence deeply embedded beliefs regarding preservation promotion relationships fathers continues effect marginalising issues safeguarding including children voiced experiences violence exceptional cases rather safeguarding concerns respect domestic violence child abuse persistently overshadowed dominant presumption overall benefits contact fathers crown copyright published elsevier ltd rights reserved
digitally controlled circuits power electronic circuits sampling data important digital control circuit operated basis data sampled values affected switching noise power circuit control stability circuit would disturbed paper proposes noiseless sampling method sample value without affected switching noise synchronous sampling method may affected switching noise depending duty ratio circuit noiseless sampling method obtain data immediately turn turn switching control circuit avoid switching noise using noiseless sampling leads disturbance control circuit enhances robustness circuit applying multisampling method experimental results presented verify current control proposed sampling method disturbed switching noise even absence noise filter
poultry pork farming typical activities small farms southern brazil production plays important social economic role many areas often main income source swine compost emerged alternative reduce volume swine wastewater transformed residue easily transported applied less environment prejudice however information literature regarding use compound source nitrogen grain crops therefore aim study evaluate poultry litter swine compost organic sources nitrogen millet crop experiment conducted years southern brazil tillage systems hapludox soil treatments control without nitrogen poultry litter swine compost mineral fertilization npk use poultry litter resulted better averages almost evaluated variables although swine compost express results good crop treated poultry litter crop swine compound applied presented better results plant parameters chemical fertilizer treatment shows two residues viable alternatives nitrogen fertilization millet cultivations
kirchhoff voltage law kvl band pass filter theory bpft utilised estimating power transfer efficiency pte power delivered load pdl magnetically coupled resonant wireless power transfer wpt using two approaches three aspects depth understanding power transfer characteristics designing high efficiency wpt system illuminated research first introducing generalised mistuning factor using diagram discriminance method kvl effect conditions source load loaded quality factors pte pdl analysed applying frequency element transformations bpft restraints butterworth chebyshev type filter wpt application revealed third verified bpft special case kvl former simplifies design analysis derived restraints latter maximal pdl original frequency transfer characteristics frequency splitting region easily achieved butterworth chebyshev type respectively pte pdl versus frequency coupling coefficient analysed detail kvl finally calculated results design examples verified experimental measurements
present study conducted protective edge long lasting military operation state israel hamas gaza hundreds rockets fired gaza various regions across country time israeli forces bombed gaza sent ground forces military operation ended days fighting cease fire warring sides aim study compare attitudes perceptions youth different religious fundamentalist societies toward war readiness peace specific violent struggle attitudes toward israeli palestinian conflict general furthermore wanted examine links attitudes personal sense coherence state anxiety compared two groups adolescents belong religious minorities israel ultra orthodox national religious sample included total subjects groups young people responded questionnaire distributed military operation still rocket fire gaza strip questionnaire included socio demographic characteristics attitudes toward military operation ways resolve israeli palestinian conflict sense coherence state anxiety results indicate groups thought conflict would resolved peacefully wars come furthermore national religious ultra orthodox adolescents thought operation would limited success limited time regarding differences groups sense coherence higher among ultra orthodox group also believed counterparts everything god hands interesting results emerged peaceful resolution linked anxiety among national religious group among ultra orthodox group relationships indicated two variables results study underscore implications ongoing political conflicts alongside growing global power religion minimizes opportunities world peace
fly ash waste product coal industries used extensively construction highway railway embankments paper describes effectiveness steel grid reinforcement form planar mattress along jute geotextile facia throughout slope fly ash backfill material models subjected loading form uniform strip loading means rigid steel plates footings series laboratory model tests carried homogeneous unreinforced reinforced fly ash slopes slope angle degrees rigid base check efficacy reinforcement improving load carrying capacity stability slope fly ash slope rigid base length reinforcement varied height slope steel reinforcement grid thickness square openings laid along width slope continuous form well coverage ratios tests conducted applying uniformly distributed load udl strip loading failure based experimental results types reinforcement cases slope continuous grid length supports maximum strip loading failure compared udl variation length reinforcement showed significant effect settlement backfill
cholesterolomics regarded identification quantification cholesterol precursors post squalene metabolites cholesterol precursors biological sample molecules include dihydroxyvitamin steroid hormones bile acids intermediates respective biosynthetic pathways short article concentrate attention intermediates bile acid biosynthesis pathways particular oxysterols cholestenoic acids molecular classes implicated aetiology diverse array diseases including autoimmune disease parkinson disease motor neuron disease breast cancer lysosomal storage disease niemann pick type autosomal recessive disorder smith lemli opitz syndrome mass spectrometry dominant technology sterol analysis including gas chromatography liquid chromatography recently matrix assisted laser desorption ionisation maldi tissue imaging studies discuss exciting biological findings recent analytical improvements authors published elsevier inc
determine sensitivity specificity hpv serology diagnostic marker hpv driven oropharyngeal squamous cell carcinoma opscc hnscc patients germany italy fresh frozen tumor tissues sera collected treatment included study hundred twenty cancer cases oropharynx head neck cancer regions outside oropharynx oral cavity hypopharynx larynx serum antibodies early late hpv proteins analyzed multiplex serology compared tumor hpv rna status gold standard tumor defined hpv driven presence hpv dna hpv transformation specific rna transcript patterns opscc hpv driven hpv seropositivity best predictor hpv driven opscc diagnostic accuracy cohen kappa hpv driven opscc hpv seropositive compared one among non hpv driven opscc resulting sensitivity specificity hnscc outside oropharynx six hpv driven patients hpv seropositivity lower sensitivity highly specific conclusion hpv seropositivity appears highly reliable diagnostic marker hpv driven opscc high sensitivity specificity might less sensitive hpv driven hnscc outside oropharynx new human papillomavirus hpv infection associated subset oropharyngeal squamous cell carcinomas opscc hpv driven opscc patients improved survival reliable marker applicable clinical operations still needed authors analyzed hpv antibody levels oncoproteins regulatory proteins serum patients molecularly defined tumor hpv status hpv serology could identify hpv driven opscc patients high sensitivity specificity hpv serology may thus represent powerful accurate diagnostic marker hpv driven opscc
background caring people dementia home requires significant amount time organization commitment therefore informal caregivers mainly relatives people dementia often feel high burden although site support groups known positive effects subjective well swb perceived social support informal caregivers cases relatives either time opportunity leave person alone support groups nearby talking time project aims close supply gap providing structured telephone based support groups germany first time international studies shown benefits informal caregivers methods talking time study randomized controlled trial effects month talking time intervention compared control group without intervention two time points baseline months control group receive talking time intervention planned sample size participants study powered detect estimated effect size psychological quality life considering two sided power caregivers informal caregivers eligible years age older cared person diagnosed dementia least four hours four days per week past six months exclusion criteria psychiatric disorders informal caregiver primary outcome mental component summary rated informal caregivers secondary outcomes informal caregivers physical component summary perceived social support caregiver scale sscs score caregiver reaction scale crs score secondary outcome care recipients neuropsychiatric inventory npi process evaluation different quantitative qualitative data sources collected address reach fidelity dosage context discussion results provide information effectiveness optimization telephone based support groups informal caregivers people dementia help guide development effective telephone based social support group interventions
accumulating evidence suggests post diagnostic insulin levels may influence colorectal cancer crc survival yet previous study examined crc survival relation post diagnostic diet rich foods increase post prandial insulin levels hypothesized glycemic insulin scores index load derived food frequency questionnaire data may associated survival specific crc subtypes sensitive insulin signaling pathway prospectively followed crc patients nurses health study health professionals follow study resulting crc deaths person years crc subtypes defined seven tumor biomarkers kras braf pikca mutations irs irs fasn ctnnb expression implicated insulin signaling pathway overall crc subtype hazard ratio confidence interval increase one standard deviation glycemic insulin scores estimated using time dependent cox proportional hazards model found insulin scores glycemic scores positively associated crc mortality index load significant positive associations appeared pronounced among pikca wild type cases fasn negative cases ranging across insulin scores however observe statistically significant interactions insulin scores pikca fasn tumor marker interaction additional studies needed definitive evidence high insulinogenic diet crc diagnosis may contribute worse crc survival new elevated circulating insulin levels associated colorectal cancer crc pathogenesis may also linked crc survival according report insulin contribution crc prognosis potentially reflected differences insulinogenic diet mortality association tumor biomarkers related insulin signaling pathway prospective cohort study crc patients high insulinogenic diet linked poor crc survival primarily crcs pikca wild type fasn negative though interactions statistically significant insulin scores also significantly associated cause mortality among fasn negative cases associations detected glycemic scores crc mortality
vehicles passing trains produce significant short term biases coordinates nearby gps stations preventing coordinates used structural monitoring bridges order study problem carried experiments receivers recording located sides rail next passing trains experiments focused trains similar characteristics velocity analysis data revealed short duration bias coordinates amplitude high spectral frequencies bias due wrong integer ambiguity fixing software defects changing geometry satellites significantly improve addition glonass satellites partly due temporary blocking certain satellites passing vehicles dynamic multipath due fast moving near field reflective surfaces dynamic multipath seems depend geometry satellites characterized shift coordinates whole interval vehicle passage well short period coordinate fluctuations related specific morphological characteristics train reflective surfaces amplitude dynamic multipath smaller horizontal coordinates also characterized clearer pattern vertical coordinates basis results certain strategies modeling dynamic multipath proposed
last plunges gamers decimated world one majority human population succumbed cordyceps fungal infection crumbling monoliths human culture social constructions morality culture explored game protagonist joel various survivors encounters narrative unfolds asks compelling questions nature morality antagonism human natural worlds whether humanity worth saving end narrative utilizes elements naturalism modern form environmental fiction
importance performance frequency regulation already acknowledged regulators independent system operators isos performance based frequency regulation market model considering regulation capacity regulation mileage constraints proposed paper proposed market high performance regulation resources higher priorities selected market market clearing prices derived lagrange relaxation analysis components market clearing prices accurately indicates correlation regulation capacity regulation mileage accommodate proposed regulation market design agc allocation algorithm adjusted based market clearing results clearing procedure market model demonstrated illustrative case proposed market design tested verified market simulations system dynamic simulations simulation results discussed compared show effectiveness proposed market design elsevier ltd rights reserved
kynurenine pathway tryptophan metabolism activated pro inflammatory cytokines kynurenine upstream metabolite pathway acts putative endothelium derived relaxing factor hypothesized play causative role pathophysiology inflammation induced hypotension show xanthurenic acid transamination product hydroxykynurenine efficacious kynurenine causing relaxation resistance artery fails relax pre contracted aortic rings mesenteric artery enhanced activating phosphorylation endothelial nitric oxide synthase nos relaxing action abrogated pharmacological inhibition nos endothelial derived hyperpolarizing factor systemic injection reduced blood pressure mice serum levels increased several fold response pulse endotoxin lipopolysaccharide lps lps induced hypotension mice prevented pre treatment kynurenine monooxygenase kmo inhibitor lowered serum levels enhanced serum levels kynurenine upf another kmo inhibitor could also abrogate lps induced hypotension data identify novel vasoactive compound suggest formation key event pathophysiology inflammation induced hypotension
ulipristal acetate upa recommended first choice hormonal emergency contraception due higher efficacy similar safety compared levonorgestrel even though trials demonstrated first mechanism action inhibition ovulation authors still postulate post fertilization effect also possible raising alert medication fostering ethical debate medline database search performed order find recent articles related upa effects ovulation fallopian tube endometrium also analyzed effects sperm function pregnancy studies conclude upa effective inhibition ovulation even administered shortly peak effects fallopian tube unclear according authors upa inhibits ciliar beat agonistic effect progesterone receptors according others antagonizes progesterone induced ciliar beat decrease concerning action endometrium embryo implantation studies concluded low dose upa used significant effect decrease endometrial thickness embryo attachment results still matter debate finally recent evidence suggests upa modulates human sperm functions effect established pregnancy date majority evidence concurs excluding post fertilization effect upa even though studies needed clarify mechanism action
substantial number evidence based treatments ebts available delivered infrequently public mental health improve quality care states systems focused ebt training however efforts rarely included objective measurement clinician fidelity feasibility issues primary goal current study evaluating feasibility behavioral rehearsal method assess analogue fidelity children mental health quality improvement initiative results indicated low representative clinician participation participants demonstrated greatest improvement post training maintenance decreases months post consultation implications future use discussed
equations compressible ideal fluids analogous electromagnetism reformulated terms hyperbolic octonions furthermore wave equations source terms generalized compact elegant form analogy fluid mechanics electromagnetism also argued considering previous octonionic formulations relevant literature
paper presents current processing current controlled universal biquad filter proposed filter employs two current controlled current conveyor transconductance amplifiers cccctas two grounded capacitors proposed configuration used either single input three outputs sito three inputs single output tiso filter circuit realizes live different standard filter junctions low pass band pass high pass band reject pass circuit enjoys electronic control quality factor single bias current without disturbing pole frequency effects non idealities also discussed circuit exhibits low active passive sensitivity figures validity proposed filter verified computer simulations using pspice
using compensation technique feed forward path improved folded cascode operational transconductance amplifier ota operates weak inversion region designed proposed configuration consists composite transistors recycling structure feed forward compensation path comparison typical folded cascode cmos miller amplifier design higher gain unity gain frequency slew rate without adversely affecting noise offset performance presented ota simulated cmos technology simulation results confirm theoretical analyses finally proposed amplifier open loop gain khz unity gain frequency supply voltage power consumption
theme article protection electrical circuits negative sequence currents sinusoidal trapezoidal waveforms suggested solution enhancement instrument current transducers used industrial relaying control applications instrument negative sequence current transducer connected rogowski coils designed authors presented article protect circuits extremely non sinusoidal currents trapezoidal waveforms instrument transducers order low pass filter suggested presence higher order harmonics protected three phase circuit low pass filter reduce thd output voltage instrument negative sequence current transducer compared harmonics currents protected circuit compensate differentiation effect typical transducer schemes paper may interest investigators engineers engaged research design commissioning protection control equipment current instrument measurement devices used industrial applications also undergraduate postgraduate students electrical engineering elsevier ltd rights reserved
backgroundorofacial clefts congenital malformations orofacial region global incidence one per live births interferon regulatory factor irf omim gene associated etiology syndromic nonsyndromic orofacial clefts aim study show evidence potentially pathogenic variants irf orofacial clefts cohorts africa methodswe carried sanger sequencing dna patients nonsyndromic orofacial clefts individuals multiple congenital anomalies presented orofacial clefts sequenced nine exons irf well untranslated regions analyses pipeline used various bioinformatics tools detect describe potentially etiologic variants resultswe observed potentially etiologic exonic splice site variants nonrandomly distributed among nine exons irf variants occurring exons novel variants also observed nonsyndromic orofacial clefts glulys asnthr multiple congenital anomalies glyval lysasn patients data also show evidence compound heterozygotes may modify phenotypes emanate irf variants conclusionsthis study demonstrates exons irf mutational hotspots cohort irf mutants induced orofacial clefts may prevalent africa population however variable penetrance expressivity observations relevant detection high risk families well genetic counseling conclusion shown may need combine molecular clinical evidence grouping orofacial clefts syndromic nonsyndromic forms
work presents fully fpga based deadbeat like predictive control scheme back back converter pmsg wind turbine systems space vector modulator svm deadbeat like predictive torque current controller used control machine side converter deadbeat power control method alpha beta frame used control grid side converter sides achieve nice steady state performances requiring tuning efforts machine grid side predictive controllers realized commercial shelf fpga based platform using single cycle timed loop sctl technique whole computation time quite short less makes calculation time compensation required effectiveness presented method verified experimental data
describe new method interactively extracts salient object surfaces medical volume data isosurface extraction one popular methods volume visualization contour connected component isosurface often represents boundary surface independent object image however infinite number isosurfaces defined image even one single isosurface may many contours therefore problem effectively finding contour represents region interest becomes important method uses contour tree user interface extracting salient contours contour tree represents possible contours topological structures geometric properties contour computed used label contour tree width color branches topological geometric properties guide users select salient contour surfaces extracted using propagation seed cells derived tree fully utilize multicore cpus manycore gpus extraction process obtain enough interactivity method applied various medical data sets results showed method seven times faster previous methods interactively visualizes salient contour surfaces representing important features data
data intensive systems governance collect process data ensure conformance set business rules testers meticulously verify data test databases extracted different steps live production stream correct application business rules simplify process allowing testers model test domain relational database automatically generate test cases representing data interactions satisfying combinatorial interaction coverage criteria paper also introduces test cases self referential interactions necessity real world databases verify test cases using human loop tool depict depict expert assistance generates complex sql queries test cases produces visual report test case satisfaction apply approach two scenarios simplify optimize periodic archiving operation verify fault codes within testing environment custom directorate tvinn system
akinesia hypokinesia bradykinesia extensively used describe motor execution disturbances applied inconsistently cover conditions greek translations would suggest investigated origins changes meaning terms time particularly relation parkinson disease searched literature use interpretation words akinesia bradykinesia hypokinesia found akinesia hypokinesia appeared terms century opposite hyperkinesia used context since time bradykinetic syndrome introduced use terms increased period due encephalitis lethargica epidemic increased discovery levodopa extensive use criteria sets bradykinesia replaced akinesia commonly used term advent internet led increase publications associated increase heterogeneity use terms review shows variation time lack unity terminology used describe range movement execution disturbances current terminology fails capture nuances challenges face documenting disturbances therefore recommend current situation may benefit objective computationally solid approach using insights network circuitry technology new developments assessment technology expected contribute new framework terminology movement disorders elsevier ltd rights reserved
aims aimed assess efficacy safety vitamin antagonist vka monotherapy atrial fibrillation patients undergoing transcatheter aortic valve implantation tavi methods results tavis since identified patients suffering concomitant received either vka monotherapy vka plus single antiplatelet therapy sapt triple anticoagulation regimen thromboembolic well bleeding complications analysed six months tavi one minor bleeding thromboembolic events occurred vka therapy initiated post tavi compared patients treated additional either single dual antiplatelet therapy incidence major life threatening bleeding complications significantly lower vka mono group vka mono vka sapt triple anticoagulation analysis combined endpoint post procedural death stroke embolism major bleeding revealed significant superiority vka monotherapy compared vka plus sapt dapt respectively conclusions vka therapy without additional antiplatelet treatment effective safe patients undergoing tavi
due limited public resources many children autism spectrum disorder families must wait several months years access early behavioral intervention ebi services service providers must thus develop alternative support models assist families placed waiting lists present study assessed social validity one initiative training coaching program parents whose children put waiting list ebi services program consisted group training sessions strategies cope child disorder based applied behavioral analysis one hour weekly follow meetings support parents interventions child course months social validity assessed parental satisfaction program perception effects family child parental stress participants generally satisfied program overall although wished frequent intensive interventions reported program positive effects psychological well family quality life child behavior however parenting stress levels found increased month period results demonstrate training individually supporting parents beneficial families children asd access early behavioral intervention immediately upon receiving diagnosis importantly however lower cost parent focused programs considered substitute intensive children driven services
natural cellulose based fibers offer low cost low density composite reinforcement good strength stiffness annual renewability biodegradability natural fibers materialized environmentally friendly alternatives synthetic fibers last two decades replacing synthetic materials traditional composites industrial manufacturing sectors automotive construction furniture consumer goods work use lignocellulosic fibers green materials engineering particularly application polymeric composite reinforcement surface treatment via ionizing radiation reviewed cellulose based materials intrinsically hydrophilic require surface modification improve affinity hydrophobic polymeric matrices enhances strength durability service lifetime resulting lignocellulosic fiber polymer composites spite long history using chemical methods modification material surfaces including surface lignocellulosic fibers recent research leans instead towards application ionizing radiation ionizing radiation methods considered superior chemical methods viewed clean energy saving environmentally friendly recent applications controlled ionizing radiation doses formulation natural fiber reinforced polymeric composites resulted products enhanced fiber polymer interfacial bonding without affecting inner structure lignocellulosic fibers applications critically reviewed contribution
previously reported heparan sulfate endosulfatases sulfs expressed articular cartilage sulf knockout mouse developed severe knee osteoarthritis study hypothesised intra articular injection sulf would prevent cartilage degeneration confirming sulf induce atdc cell death vitro gene expression type collagen matrix metalloproteinase mmp presence sulf determined quantitative real time polymerase chain reaction sulf also injected intra articularly mice following surgical destabilisation medial meniscus produce model osteoarthritis cartilage degeneration evaluated safranin mmp staining also investigated fibroblast growth factor fgf extracellular signal regulated kinase erk cell signalling western blotting exposure sulf vitro increased type collagen expression decreased mmp expression concentration dependent manner sulf injection mouse osteoarthritic knee significantly suppressed glycosaminoglycan loss mmp expression erk signalling pathway activation significantly reduced sulf fgf findings indicate sulf prevents cartilage degeneration suppressing mmp via effect fgf erk signalling
social stress modifies activity brain areas involved rewarding effects psychostimulants inducing neuroadaptations dopaminergic mesolimbic system modifying sensitivity dopamine receptors present study evaluated effect dopamine like receptor antagonists sch raclopride respectively short time effects acute social defeat asd male mice socially defeated conditioning session conditioned place preference cpp induced cocaine plus corresponding dopamine antagonist final experiment designed evaluate effect dopamine antagonists cpp induced cocaine without stress experience mice exposed asd showed increase reinstatement conditioned reinforcing effects cocaine blocked dopamine receptor antagonists blockade dopamine like receptors raclopride specifically prevented effects stress without affecting rewarding properties cocaine however sch inhibited cocaine induced preference control groups even induced aversion defeated mice conditioned lower dose cocaine moreover lowest dose sch blocked rewarding effects cocaine induced cpp results confirm dopamine receptor involved short term effects asd rewarding effects cocaine dopamine receptor clearly involved rewarding effects cocaine role effects asd remains demonstrated
present study aimed investigate relationship overall emotional intelligence components reflectivity impulsivity learning style iranian efl learners emotional intelligence learning style female efl learners avaye morad takro private institutes tabriz obtained bar emotional quotient inventory learning style questionnaire pearson correlation analyses conducted measure degree relationship emotional intelligence well components learning style participants results correlation analyses indicated overall emotional intelligence statistically positive relationship learning style efl learners also found among components emotional intelligence intrapersonal adaptability stress management components revealed significant relationship learning style participants results study could help textbook designers curriculum planners foreign language institutes teachers learners parents provide use different methods teaching learning
ambient noise variability critical challenge encountered multiple stakeholders including sonar designers operators among sources ambient noise ocean wind related noise significant impact sonar performance tropical waters indian ocean region ior present random fluctuations surface parameters namely wind speed surface temperature wave height etc resulting variations ambient noise characteristics site specific surface fluctuations tropical regions restrict possibility generalized algorithm design mitigate ambient noise impact work attempts study variations ambient noise levels corresponding fluctuations surface parameters site specific behavior tropical ior demonstrated using surface data available moored buoy three distinct locations ior analysis methodology used characterize predict improve sonar performance particularly severe conditions tropical ior
availability continental global scale spatio temporal geographical data sets requirement efficiently process analyse manage led development temporally enabled geographic resources analysis support system grass gis present temporal framework extends grass gis spatio temporal capabilities framework provides comprehensive functionality implement full featured temporal geographic information system gis based combined field object based approach significantly improved snapshot approach used manage spatial fields raster three dimensional raster vector type time resulting timestamped spatial fields organised spatio temporal fields referred space time data sets types fields handled objects framework spatio temporal extent objects related metadata stored relational databases thus providing additional functionalities perform sql based analysis present combined field object based approach detail show management analysis processing spatio temporal data sets complex spatio temporal topologies key feature hierarchical processing spatio temporal data ranging topological analysis spatio temporal fields boolean operations spatio temporal extents single pixel voxel vector feature access linear scalability approach demonstrated handling raster layers single space time data set provide several code examples show capabilities grass gis temporal framework present spatio temporal intersection trajectory data demonstrates object based ability framework
model updating damage detection structural health monitoring shm modal identification usually first step calculate modal properties natural frequencies damping ratios mode shapes targeted structure utilizing measured time domain responses ambient vibration test provides efficient economical mean collect structural vibration responses purpose modal identification since artificial excitation required paper presents work ambient vibration test modal identification recently constructed boat shaped building situated hong kong building isolated structure connected secondary structure fourth fifth floors identify detail mode shapes sixty two measurement points desired located three staircases minimize effect normal operation building typical floor building due large number measurement points coving almost floors building multiple setups moving references approach designed common problems encountered field test discussed paper recently developed fast bayesian fft method employed perform modal identification method could identify probable value mpv modal parameters efficiently also calculate associated posterior uncertainty analytically providing important tool evaluate accuracy modal parameters first nine modes identified including five translational modes two torsional modes one combined mode one vertical mode due connections building torsional behavior observed translations modes based mpv associated uncertainty variability modal parameters across different setups also addressed interesting feathers structure studied investigated providing baseline future shm condition assessment building elsevier ltd rights reserved
drylands occupy kenya total land mass contribute immensely national economy society agriculture livestock production tourism wild product harvesting dryland ecosystems areas high climate variability making vulnerable threats land degradation consequently agropastoralists inhabiting ecosystems develop mechanisms technologies cope impacts climate variability study aimed determine agropastoralists inhabiting semi arid ecosystem kenya attribute causes indicators land degradation document sustainable land management slm technologies undertaken combat land degradation identify factors influence choice slm technologies vegetation change preferred indigenous forage grass species woody vegetation cited main indicator land degradation land degradation attributed recurrent droughts low amounts rainfall overgrazing unsustainable harvesting trees fuelwood production however despite challenges posed climate variability recurrent droughts local community engaging simple slm technologies including grass reseeding rainwater harvesting soil conservation dryland agroforestry holistic approach combating land degradation improving rural livelihoods choice slm technologies mainly driven additional benefits combating land degradation conclusion promoting simple slm technologies help reverse land degradation trend improve agricultural production food security including access food subsequently improve livelihoods communities inhabiting dryland ecosystems
chronic myeloid leukemia cml polycythemia vera essential thrombocythemia primary myelofibrosis pmf myeloproliferative neoplasms mpn characterized clonal myeloproliferation without cell maturation impairment cml pathogenesis associated chromosome leading bcr abl tyrosine kinase constitutive expression negative mpn pmf characterized mutation jak jak protein auto inhibitory domain found patients approximately half pmf patients considerable effort beingmade understand role jak mpn initiation clarify pathogenesis apoptosis resistance cml pmf patients present investigation evaluated death inducer obliterator dido variants dido levels cml pmf patients data reported dido differential expressions myeloproliferative neoplasms elsevier inc rights reserved
widely believed two alternative forced choice afc old new recognition memory test made comparing two items choosing item higher strength reason considered criterion free researchers found evidence subjects probabilistically compromised comparison choosing left item recognized old using normal test pairs comprised one new one old item two types null pairs comprised new old items found left biased choice coupled higher hit false alarm rates shorter left right choice normal pairs consistent hypothesis bias making choice basis left individual item recognition null pairs much longer new old pairs providing additional evidence basing decision individual item absolute rather relative familiarity additionally subjects gave higher confidence ratings choices old normal new pairs suggesting decision based absolute familiarity items results found due fast response instruction comparative judgment experiment subjects chose item higher lower attribute magnitude show response side bias asymmetry presence bias former absence latter explained weak versus strong relational judgment former latter type afc respectively discuss implications findings use afc method testing recognition memory elsevier rights reserved
purpose lack comprehensive reviews targeting specific aspects functioning difficulties faced persons alcohol dependence aim present review systematically compile existing literature activity limitations participation restrictions defined international classification functioning disability health icf context alcohol dependence methods database search medline psychinfo performed studies published english examining activity limitations participation restrictions alcohol dependence using standardised protocol information studies characteristics data activity limitations participation restrictions evolution onset determinants associations variables extracted studies review results total difficulties activities participation persons alcohol dependence extracted papers spectrum studies wide overall quality good common reason exclusion studies inconclusive definition alcohol dependence issues interpersonal interactions economic professional life dealing aggression legal problems frequently reported difficulties problems high risk behaviours seeking appropriate treatment also common frequent determinants onset evolution identified difficulties factors pertaining course alcohol dependence difficulties rarely studies focus therefore data underlying causes courses limited conclusions results confirm alcohol dependence profoundly affects family social network afflicted person treatment alcohol dependence contribute alleviation associated difficulties icf offers new perspective evaluating wide range difficulties encountered context alcohol dependence
increasingly growing amount service requests world wide customers cloud systems capable providing services meeting customers satisfaction recently achieve better reliability performance cloud systems largely depending geographically distributed data centers nevertheless dollar cost service placement service providers differ multiple regions accordingly crucial design request dispatching resource allocation algorithm maximize net profit existing algorithms either built upon energy efficient schemes alone multi type requests customer satisfaction oblivious applied multi type requests customer satisfaction aware algorithm design objective maximizing net profit paper proposes ant colony optimization based algorithm maximizing net profit amp geographically distributed data centers consideration customer satisfaction first using model customer satisfaction formulate utility net profit maximization issue optimization problem constraints customer satisfaction data centers second analyze complexity optimal requests dispatchment problem rigidly prove complete problem third evaluate proposed algorithm conducted comprehensive simulation compared state art algorithms also extend work consider data center power usage effectiveness shown amp maximizes net profit dispatching service requests proper data centers generating appropriate amount virtual machines meet customer satisfaction moreover also demonstrate effectiveness approach accommodates impacts dynamically arrived heavy workload various evaporation rate consideration power usage effectiveness copyright john wiley sons ltd
introduction cardiovascular risk marker tissue plasminogen activator antigen reduced long term exercise interventions unknown whether due weight loss induced physical activity due physical activity per materials methods tested healthy younger years overweight bmi men randomly assigned weeks intervention one four groups training energy reduced diet training increased diet sedentary lifestyle unchanged diet controls fasting blood samples obtained weeks intervention analyzed plasma results body weight reduced groups observed decrease baseline weeks three exercise diet intervention groups change control group group difference observed weeks due lower values compared control group total body fat mass reduced three exercise groups observed positive correlation changes changes intra abdominal subcutaneous adipose tissue volume conclusions results demonstrate reduced three intervention groups suggests weeks endurance training per irrespective concomitant weight loss beneficially affects cardiovascular risk healthy younger overweight men elsevier ltd rights reserved
mulching increasingly employed stabilize burnt areas making necessary elucidate used effects mulching efficiency two straw application strategies reducing nutrient losses evaluated steep area burnt moderate severity twelve experimental plots split three sets control burnt plots burnt plots straw mulching narrow bands along contour lines global dose wide bands global dose none mulching strategies significant effect soil sediment variables analysed nutrient trace element concentrations principal component analyses show soil sediment samples change time fire regardless treatment decreasing progressively differences successive sampling dates sediments kcl fitted curvilinear regression models time fire independent variable variables showed clear temporal trend first post fire year sediments eroded mulching effect total mass lost sediment nutrients conclude erosion rate rather low year due moderate precipitation rates therefore mulching significantly reduce soil erosion nevertheless concentration sediments exceeded reference levels ecosystem protection lead deficiency problems site vegetation soil water pollution site elsevier rights reserved
topically applied hydrogel system general therapeutic mask transdermal delivery hydrophobic actives efficient due differences polarity actives polymer network work presents study developing hydrogels based carrageenan matrix delivery hydrophobic type active tocotrienol rich palm based vitamin trpe skin strength flexibility hydrogel increased inclusion guar gum potassium citrate glycerine thermogravimetric analysis tga results indicated higher quantity water hydrogel glycerine differential scanning calorimetry dsc showed three types water molecules existed hydrogel hydrogel non irritating according oecd test guideline vitro skin irritation test hydrogel trpe fluids able permeate polysulfone membrane bioavailability trpe improved inclusion peg hydrogenated castor oil mixture therefore carrageenan based hydrogel locust bean guar gum glycerine potassium citrate trpe successfully developed good strength flexibility without potential irritancy good bioavailability trpe loaded hydrogel used skin care application
online laboratories useful valuable resources high education especially engineering studies work presents methodology create effective laboratories learning interact learning management system lms achieve advanced integration based pedagogical aspects considers laboratory application also related resources complement methodology flexible covers possible cases structured stages used system architecture standards type online laboratory virtual remote hybrid abstracts technical aspects high level methodology facilitates creation new online labs teacher even without specialized knowledge clarify many questions may arise gain understanding implement effective online laboratory lms integration assist learning example validation methodology work describes laboratory developed shared content object reference model scorm package hosted institutional lms university jaen laboratory presented students taking industrial automation class student evaluations quite positive
based previous studies linked emotional disorders including depression memory biases aim present study assess relation depression memories negative life events specifically aimed investigate individual differences depressive state evocation veridical false memories study occurrence veridical false memories video paradigm used videos related details shown presented recognition task order induce spontaneous false memories sample participants completed study exchange course credits watching video participants reported current depressive state completing beck depression inventory watching video participants completed recognition task asked indicate whether seen particular detail video results revealed significant differences level veridical memories reported specifically participants high level depression reported low level veridical memories compared participants low level depression differences participants low level depression participants high level depression evocating false memories significant results discussed perspective clinical implications
high levels worry common phenomenon undergraduate populations undergraduates introductory psychology courses classified high worriers worry characterized pervasive neglect present moment persistent thoughts future various methods increasing present moment focus devised purpose study compare effects two brief present moment awareness training paradigms mindfulness meditation present moment joy high worriers although paradigms seek increase present moment awareness processes different potentially contradictory prior studies compared two paradigms field yet examine present moment joy independent technique ninety seven high worriers completed two minute training sessions across days either mindfulness meditation present moment joy participants rated levels state mindfulness curiosity decentering affect anxiety session conditions increased curiosity decentering mindfulness meditation led greater decentering changes day present moment joy conditions decreased anxiety negative affect present moment joy increased positive affect results suggest although mindfulness meditation present moment joy operate via different mechanisms increase present moment awareness reduce anxiety negative affect however one goal also increase positive affect present moment joy may effective intervention
finite element model yueyang dongting lake bridge established large scale general finite element analysis software subspace iteration method adopted analyze natural vibration characteristics bridge meanwhile influences settings different types central buckles mid span main spans main cables girder dynamic behaviors long span suspension bridge deck truss composite stiffening girder studied results show compared setting short hanger cable mid span whole rigidity suspension bridge raised natural frequencies increase setting central buckle various types vibration modes affected different extents among vibration modes antisymmetric vibration longitudinal floating stiffening girder obviously affected stiffness central buckle great influence vibration main cable compared setting short hanger cable vibration main cable increases setting rigid central buckle conclusions paper provide theoretical basis using central buckle long span suspension bridge
background cancer emerging major cause childhood mortality low middleincome countries inmexico cancer number one cause death children aged recently many children cancer baja california mexico went untreated reasoned initiative inspired jude children research hospital sjcrh twinning model could successfully applied san diego tijuana border region twinning project initiated rady children hospital sjcrh general hospital tijuana ght aim establish pediatric oncology unit culturally sensitive manner adapted local healthcare system procedure initial assessment revealed despite existence basic hospital infrastructure ght essential elements pediatric cancer unit lacking including dedicated space trained staff uniform treatment year action plan designed offer training support staff financially improve infrastructure results years accomplishments include opening new inpatient unit updated technology fully trained staff dedicated interdisciplinary team children benefited accurate diagnosis treatment conclusions initiatives implement long term partnerships institutions along mexican north american border highly effective establishing successful pediatric cancer control programs geographic proximity facilitated accelerated training close monitoring project development similar initiatives across disciplines may benefit additional patients synergize pediatric oncology programs reduce health disparities underserved areas
objective aim characterize sle medication trends pregnancy compare commonly used medications sle pregnancies non sle pregnancies methods women pregnancies ending live birth stillbirth identified swedish medical birth register national registers used identify women prevalent sle pregnancy sample without sle identify prescription medications dispensed months pre pregnancy months postpartum reported prevalence dmards systemic css nsaids aspirin reported separately sle pregnancies calculated prevalence estimates medications dispensed pregnancy sle pregnancies medications among non sle pregnancies results pregnancies among women sle pregnancies among women without sle sle pregnancies one dispensing dmards pregnancy prevalence css aspirin nsaids varied pregnancy period prevalence common medications among sle pregnancies fold higher among non sle pregnancies example dalteparin paracetamol levothyroxine conclusion nearly half sle pregnancies women dispensed dmards css commonly used medications sle pregnancies far higher prevalence estimates compared non sle pregnancies research regarding benefits risks commonly used medications sle pregnancies breast milk long term outcomes offspring needed
declaring thinking heroes common human preoccupations surprisingly aspects heroism reinforce behaviors well understood four thematically consistent studies attempt identify lay perspectives psychological functions served heroes study participants freely generated open ended descriptions hero functions sorted independent coders categories instill hope guide others study attempt identify important functions associated heroes participants rated function corresponded personal views heroes results confirmatory factor analysis suggested three factor model hero functions fit data well participants thought heroes enhanced lives others promoted morals protected individuals threats study participants rated heroes likely fulfill protecting function either leaders role models studies participants indicated thinking hero relative leader acquaintance psychological threat fulfilled personal enhancement moral modeling protection needs findings provide empirical basis spur additional research social psychological functions heroes offer
background anorexia nervosa destroys developmentally important early years many young people knowledge insufficient regarding course treatment outcome prognosis naturalistic studies conducted within field eating disorder research naturalistic study included adolescents subthreshold treated outpatient care overall aim examine sample characteristics treatment outcome additional aims examine potential factors associated remission outcome variable possible differences three time periods treatment onset methods participants identified swedish national quality register eating disorder treatment sweat patients registered treatment onset followed year end treatment eot inclusion criteria medical self referral one participating treatment units years age initial entry sweat diagnosed subthreshold total sample consisted patient different treatment units results results show participants remission approximately within healthy weight range eot ended treatment according plan remission within healthy weight range average treatment duration approximately months one third patients terminated treatment prematurely associated decreased chance achieving remission remission rates weight recovery increased time treatment duration decreased considering treatment outcome results show differences patients subthreshold conclusions present study shows relatively good prognosis adolescent patients subthreshold routine care results indicate treatment adolescents sweden become effective past years results present study contribute scope treatment research large scale naturalistic setting secures generalizability clinical environment however research needed different forms evidence new research strategies diversity treatment approaches
objective abundance experimental studies motivated range models concerning cognitive underpinnings severe mental disorders yet conception cognitive brain dysfunction confined specific cognitive domains contexts limited ecological validity schizophrenia bipolar spectrum disorders conceptualized disorders brain connectivity yet little known pervasiveness across cognitive tasks methods address outstanding issue context specificity estimated functional network connectivity fmri data obtained five cognitive tasks back back recognition positive faces negative faces patients schizophrenia spectrum patients bipolar spectrum disorder healthy controls including fmri datasets total tested main effects task group interactions used machine learning classify task labels predict cognitive domain scores brain connectivity results connectivity profiles positively correlated across tasks supporting existence core functional connectivity backbone common tasks however network links also showed significant task related alterations robust single subject level evidenced high machine learning performance classifying task labels independent task specific modulations network links showed significant group effects particularly including sensory sensorimotor visual auditory cognitive frontoparietal default mode dorsal attention networks lack group task interactions revealed pathophysiological sensitivity remained across tasks pervasiveness across tasks supported significant predictions cognitive domain scores connectivity backbone obtained across tasks conclusions high accuracies obtained classifying cognitive tasks support brain connectivity indices provide sensitive specific measures cognitive states importantly provide evidence brain network dysfunction severe mental disorders confined specific cognitive tasks show connectivity backbone common tasks predictive cognitive domain traits pervasiveness across tasks may support generalization pathophysiological models different domains thereby reducing complexity increasing ecological validity future research incorporating wider range cognitive tasks involving sensory modalities auditory somatosensory motor requirements learning perceptual inference decision making etc needed assess certain circumstances context dependent aberrations may evolve results provide evidence large sample fmri based functional network connectivity used reveal state trait effects connectome
studies process acoustic stimulation prenatal period require assess beneficial condition child development well characteristic sounds could negatively affect development auditory system brain even entire body provided simplified model sound attenuation uterus represented first order passive low pass filter basis total harmonic distortion analysis single sound proposal indicating sound reduction intrauterine environment formulated hypothesised sound stimuli uterus sound music source
spreading depolarizations occur high frequency patients malignant hemispheric stroke mhs experimentally sds cause marked increases glutamate lactate whereas glucose decreases studied extracellular brain glutamate glucose lactate pyruvate lactate pyruvate ratio relationship sds mhs inserted two microdialysis probes peri infarct tissue infarct close proximity subdural electrode strip monitoring hours electrocorticography ecog revealed sds patients ninety nine sds electrically active tissue spreading depressions sdd single sdds clustered sddc whereas sds least one electrode electrically inactive tissue isoelectric sds sdi single sdis clustered sdic sds significant number clustered sds occurred first post surgery glutamate significantly elevated grouped analysis observed minor glutamate elevations two sds per hour glucose slightly decreased sdic infarct directions related metabolic changes correspond experimental setting long sampling time standard microdialysis precludes adequate account dynamics revealed ecog
distribution plant material key parameter describe vegetation structure influences several processes radiation interception ecosystem functioning vegetation covers often described using leaf area index lai plant area index pai monitoring modeling purposes characterizing vegetation structure fine scale increasingly required notably order able apply radiative transfer simulations scales consistent spatial resolution recent remote sensing sensors assess pai vegetation plot paper evaluates potential voxelization method using terrestrial laser scanning tls data based beer lambert transmittance computation law theoretical validation performed using simulation framework based radiative transfer model dart framework allowed simulating tls acquisition theoretical distribution leaves realistic representation single tree characteristics well known hence sensitivity analysis performed study influence instrument parameters single multi echo beam divergence scanning configuration scan angle step vegetation characteristics leaf size density leaf angle distribution voxel parameters cubic versus spherical geometry different resolutions without occlusion estimation pai theoretical distribution leaves results showed good accuracy voxelization method rmse mean case voxel level high resolution multi echo tls scan cubic voxels resolution low inter voxel occlusion small leaves surface density error increased larger scan angle resolution single echo tls systems vegetation density also without clumping error increased smaller voxels larger leaves best results obtained multi echo tls scans angular resolution cubic voxels resolution occlusion low voxel sampling higher maximum sampling small leaves provided good agreement rmsd realistic isolated tree pai correctly assessed cubic voxels resolution method merge voxelized scans proposed deal inter voxel occlusion effects elsevier inc rights reserved
cement paste cement mortar concrete common engineering cement based materials performance much affected internal pore structure carbonation transform calcium hydroxide cement based materials calcium carbonate improving internal pore structure improve performance supercritical carbon special carbonization conditions accelerated carbonation efficiency study effect supercritical carbonization paper test research finished change strength carbonation depth carbon dioxide absorption cement base material supercritical conditions found accelerated carbonation rapid carbonization cement base material achieved strength materials increased sharply time large number absorbing double meaning material performance environmental protection
mobile cloud computing mcc state art mobile distributed computing model incorporates multitude heterogeneous cloud based resources augment computational capabilities plethora resource constraint mobile devices mcc execution time energy consumption significantly improved transferring execution resource intensive tasks image processing rendering voice recognition hosting mobile cloud based resources however accessing exploiting remote cloud based resources associated numerous security privacy implications including user authentication authorization user authentication mcc critical requirement securing cloud based computations communications despite critical role gap comprehensive study authentication approaches mcc provide deep insight state art research paper presents comprehensive study authentication methods mcc describe mcc authentication compare cloud computing taxonomy state art authentication methods devised credible efforts critically reviewed moreover present comparison state art mcc authentication methods considering five evaluation metrics results suggest need futuristic authentication methods designed based capabilities limitations mcc environment finally design factors deemed could lead effective authentication mechanisms presented open challenges highlighted based weaknesses strengths existing authentication methods elsevier ltd rights reserved
home security become prime concern everyone present scenario work attempt made develop home security system accessible affordable yet effective proposed system based remote embedded control system recs works web gsm platform authentication monitoring system therefore cost effective relies existing network infrastructure pca popular efficient algorithm face recognition usedin work next interface developed communication purpose embedded security system zigbee module based embedded system automated control door movement implemented electromagnetic door lock technology helps users monitor real time activities web services sms web service consists either web browser command mail provision system establishes communication system authenticated user mail received system authorized person monitor control real time operation door lock entire control system reinforced using armjzf microcontroller tested actual use home environment result shows experimental verification proposed system
expansion electricity grid connected photovoltaic sources requires development solutions solving problems caused disturbances electrical network due strong variable character energy sources power generation grid connected photovoltaic plants increasing world plants crucial part future electric energy system restrict level electromagnetic disturbance currently effective technical solutions based power electronics paper deals issue power quality alteration assessing power electronics equipment operation mode grid connected plants normal restricted conditions operation general analysis performed first section identifying current state art photovoltaic plants influence power quality example designed starting real electric distribution system order create general image issues solutions
developed process oriented method intrusion detection use industrial control system ics networks network traffic ics much lower volume typical enterprise network traffic much regular periodic predictable intrusion detection systems icss require additional capabilities ics network traffic relatively predictable regular anomaly based intrusion detection methods shown literature work reasonably well use anomaly based methods one line defense propose strengthen ics intrusion detection methods adding two process oriented alerting methods unlike anomaly detection methods two methods configured solely network engineer based inspection network traffic utilize critical process variables defined plant operators advantage plant operators best knowledge critical assets system limiting values critical process variables defined collaboratively plant operator network security engineer network sensor alerts human analyst critical process variables values exceed defined ranges also introduce third method employs process network parameter metrics also defined collaboratively plant operator process network parameter metrics pre defined measurements network traffic may indicate either process components missing additional traffic present process normally produce initial discussions plant operator network security engineer designs network models metrics appropriate alerting functions network sensor alerts process network parameter metrics may indicate critical security incident critical process variables would may provide important warning suspicious behavior present
developmental toxicity caused exposure mixture environmental pollutants become major health concern human made chemicals including xenoestrogens pesticides heavy metals well unhealthy lifestyle behaviours mainly tobacco smoking alcohol consumption medical drug abuse major factors adversely influence prenatal development increase susceptibility offspring diseases evidence suggest developmental toxicological mechanisms chemicals lifestyle factors involve generation reactive oxygen species ros cellular oxidative damage overproduction ros induces oxidative stress state increased ros generation overwhelms antioxidant protection subsequently leads oxidative damage cellular macromolecules data involvement oxidative stress mechanism developmental toxicity following exposure environmental pollutants reviewed attempt provide updated basis future studies toxic effect pollutants particularly notion increased risk developmental toxicity due combined cumulative exposure various environmental pollutants aims studies better understand mechanisms environmental pollutants adversely affect conceptus development elucidate impact cumulative exposures multiple pollutants post natal development health outcomes reproductive healthcare ltd published elsevier ltd rights reserved
aluminum graphite composites used self lubricating materials due superior lubricating effect graphite sliding paper summarizes various tribological aspects self lubricating aluminum composites influence various factors material factors graphite size volume fraction mechanical factors applied load sliding speed tribological properties self lubricating aluminum composites discussed furthermore tribological properties self lubricating composites function parameters active wear mechanism involved various systems discussed bringing self lubricating composites different operating systems solution reduce use external toxic petroleum based lubricants sliding contacts way help environment reduce energy dissipation industrial components strategies toward sustainability energy efficiency
neuromodulation emerging area headache management neurostimulation multiple brain areas modulated alleviate pain hence reducing pharmacological need review discuss recent development vagus nerve stimulation vns headache management early case series epilepsy depression cohorts using invasive vns showed serendipitous reduction headache frequency severity noninvasive vns nvns stimulates carotid vagus nerve use personal handheld device also demonstrated efficacy acute migraine cluster headache attacks long term use nvns seemed exert prophylactic effect chronic migraine chronic cluster headache animal studies nvns modulated multiple pain pathways even lessen cortical spreading depression progression nvns clinical efficacy time suggests underlying disease modifying neuromodulation noninvasive vns appears effective invasive counterpart many indications enormous potential therapeutic gain high safety profile development application nvns promising
investigated family members lived experience parkinson disease aiming investigate opportunities well lifeworld led approach healthcare adopted interpretative phenomenological analysis used explore depth interviews people living partners analysis generated four themes illness revealed existential challenge diagnosis like bird broken wing emphasizing need adapt increasing immobility embodied agency together exploring kinship within couples belonging experienced support groups carpe diem illuminated significance time fractured future orientation created diagnosis findings interpreted using existential phenomenological theory well highlighted partners shared impact ontological challenges research different types families different situations required identify services required facilitate process learning live care support family unit needs provide emotional support manage threats identity agency alongside problem solving bodily changes adopting lifeworld led healthcare approach would increase opportunities well within illness journey
address important step determining effective subset heuristics selection hyper heuristics little attention devoted literature decision left discretion investigator performance hyper heuristic depends quality size heuristic pool using one heuristic generally advantageous however unnecessary large pool decrease performance adaptive approaches goal bring methodological rigour step proposed methodology uses non parametric statistics fitness landscape measurements available set heuristics benchmark instances order produce compact subset effective heuristics underlying problem also propose new iterated local search hyper heuristic using multi armed bandits coupled change detection mechanism methodology tested two real world optimization problems course timetabling vehicle routing proposed hyper heuristic compact heuristic pool outperforms state art hyper heuristics competes problem specific methods course timetabling even producing new best known solutions studied instances elsevier rights reserved
photovoltaic technology allows directly convert solar energy electrical energy clear advantages environmental impact operation reliability durability systems reduced operating costs maintenance ability supply remote customers simply connect electrical network paper evaluates performance two photovoltaic systems one fixed one equipped sun tracker objective research analyze increase daily produced energy using sun tracking system analysis accounts also energy consumption sun tracker analytical approach proposed validate results experimental tests two alternative low power systems built system consists source mppt maximum power point tracker power converter electrochemical battery used electric load sun tracker system evidenced important growth power production morning evening elsevier ltd rights reserved
work reports new gated nanodevice acetylcholine triggered cargo delivery prepared characterized janus mesoporous silica nanoparticles functionalized acetylcholinesterase face supramolecular cyclodextrin benzimidazole inclusion complexes caps mesoporous silica face nanodevice able selectively deliver cargo presence acetylcholine via enzyme mediated acetylcholine hydrolysis locally lowering opening supramolecular gate given key role played ach relation parkinson disease nervous system diseases believe findings could help design new therapeutic strategies
authors describe method producing boolean functions degree variables functions plateaued balanced high nonlinearity linear structures nonlinearity largest possible nonlinearity quadratic function odd variables called quadratic bound theorem uses new ideas generalise theorem gave case paper fengrong zhang discuss cryptographic properties applications functions
epidemiological studies indicate patients type diabetes mellitus tdm increased risk developing dementia alzheimer disease review based recent studies presents molecular framework links two diseases explains physical training could help counteract neurodegeneration tdm patients inflammatory oxidative metabolic changes tdm patients cause cerebrovascular complications lead blood brain barrier bbb breakdown peripherally increased pro inflammatory molecules pass bbb easily activate stress activated pathways thereby promoting key pathological features dementia brain insulin resistance mitochondrial dysfunction accumulation neurotoxic beta amyloid beta oligomers leading synaptic loss neuronal dysfunction cell death ceramides also pass bbb induce pro inflammatory reactions disturb brain insulin signaling vicious circle oxidative stress pro inflammatory environment intensify leading cognitive decline low testosterone levels might common risk factor tdm regular physical exercise reinforces antioxidative capacity reduces oxidative stress anti inflammatory effects improves endothelial function might increase brain capillarization physical training counteract dyslipidemia reduce increased ceramide levels might also improve beta clearance regulating beta transporters cases increase basal testosterone levels addition regular physical activity induce neurogenesis physical training therefore emphasized part prevention programs developed diabetic patients minimize risk onset neurodegenerative diseases among specific patient group
clear compelling racial disparities access renal transplant therapy choice many patients end stage renal disease paper conceptualizes role racism internalized personally mediated institutionalized creating perpetuating disparities multiple levels social ecology integrating two often cited theories literature internalized racism manifested intrapersonal level example african american patients devalue self worth thereby pursuing aggressive treatment available personally mediated racism manifested interpersonal level example physicians exhibit unconscious race bias impacts treatment decisions one example institutionalized racism manifested institutional community public policy levels long standing existence racial residential segregation empirically established links neighborhood racial composition dialysis facility level transplantation rates paper concludes clinical research policy recommendations
author presents general synthesis method realisation nth order voltage transfer function using active circuit comprising commercially available active component equivalent combination second generation current conveyor gain ccii unity gain voltage buffer use active component simplifies implementation making proposed circuit attractive
geosynthetics reinforced soil grs walls constructed weak grounds may change horizontal earth pressure deformation wall facing however studies done literature measure analyze horizontal external deformation behavior grs walls constructed soft grounds long period time present study describes external deformation behavior grs walls observed year long term performance horizontal deformation geosynthetics wrapped facing grs walls shows passive behavior along one third wall height top going downwards active behavior rest wall height even geogrid nonwoven geotextiles exposed directly sunlight rainfalls span years functioned well wall facing therefore geosynthetic reinforcement material strong enough resist ultraviolet rays
tactical edge networks provide one challenging communication environments order cope node mobility constrained resources link unreliability communication solutions designed tactical edge networks typically present highly configurable interfaces adaptable various networking conditions however extreme dynamicity heterogeneity tactical scenarios call network aware adaptive communication systems continuously tune configuration parameters match ever changing network conditions paper presents dynamic detect adapt mechanism ddam agile communication middleware distributed solution perform network monitoring communication adaptation specifically designed tactical edge networks present work focuses two components ddam netsensor provides efficient monitoring network status netsupervisor responsible characterizing network technology used connect pair nodes network presented results show solution accurately identify technology used establish links nodes
movement primitive segmentation enables long sequences human movement observation data segmented smaller components termed movement primitives facilitate movement identification modeling learning applied exercise monitoring gesture recognition humanmachine interaction robot imitation learning paper proposes segmentation framework categorize compare different segmentation algorithms considering segment definitions data sources application specific requirements algorithm mechanics validation techniques framework applied human motion segmentation methods grouping online semionline offline approaches among online approaches distance based methods provide best performance stochastic dynamic models work best semionline offline settings however algorithms date tested small datasets algorithm generalization across participants movement changes remains largely untested
flexible querying developed aim proposing powerful user friendly ways setting solving queries within context flexible querying use bipolar queries deserved attention research community way distinguishing queries negative positive assessments data bipolar queries specially studied framework crisp relational databases paper propose approach bipolar queries fuzzy object databases use generalized inclusion concept deal bipolar conditions fuzzy univalued multivalued attributes consistence proposed approach bipolar queries rationale also analyzed elsevier rights reserved
paper proposes new method dead time effect compensation proposed solution based additional phase current measurements realized analog digital converters measurements carried time instants specified pulsewidth modulation pwm strategy makes possible estimate inverter currents commutation instants finally estimate voltage error caused dead time voltage error compensated next switching period modification reference voltage proposed solution used compensate voltage error multilevel multiphase voltage source inverters experimental research studies carried three phase two level three level neutral point clamped inverters supplying motors respectively results experimental investigations presented paper
scaling semiconductor devices past decades made possible continuous innovations materials engineering well device integration geometries thermal processing enabler manufacturing advanced devices unit process concert key technologies like ion implantation epitaxy film deposition paper reviews evolution annealing technology special consideration thermodynamics kinetics integration thermal budgets equipment process innovations meet ever changing material device fabrication requirements presented
current research posited stigma prejudice transfer effect proposes stigmatized group members white women threatened prejudice directed stigmatized group members african americans believe prejudice monolithic qualities stigma researchers assume direct correspondence attitude prejudiced individuals targets sexism affects women racism affects racial minorities five studies reported demonstrate white women threatened racism study men color sexism study robust perceptions liking order measures administered results showed prejudice transfers racism sexism driven presumed social dominance orientation prejudiced individual addition important downstream consequences increased likelihood anticipated stigma expectations unfair treatment attribution negative feedback sexism appeared stigmatized individuals
sensing computing communication main features wireless sensor network wsn serves wide range applications despite versatility simplicity brought various challenges limited storage power consumption radio activities mention distinguishing traits sensor networks direct impact protocol design layer especially medium access control mac layer since manages transmission scheduling well duty cycling energy conservation maximize energy efficiency wsns critical analysis radio duty cycle wsn operating systems carried experimental evaluation moreover focus energy consumption conducting experimental measurements different platforms openmote various operating systems results shows ieee time synchronized channel hopping tsch great impact energy consumption respect radio duty cycles
deformational properties fatigue asphalt layers important design assessment semi rigid flexible pavements two point bending test used determination deformational characteristics asphalt mixtures department construction management zilina results evaluated katems assessment software long term research lead estimation deformational characteristics fatigue different types asphalt mixtures tests shown positive impact additives ground rubber hydrate lime component recycling materials results mixtures
deep models recently shown improved performance numerous benchmark tasks computer vision machine learning availability huge amount digital data possibility massively parallel computations graphics processing units development advance optimisation techniques pushed limits deep learning framework superseding performance state art research specific kernel methods research proposes novel connection two paradigms research shows empirical evidence emphasise knowledge learnt one domain could supplemented significant properties domain achieve best worlds proposed hybrid methodology illustrates advantages deep architectures kernel methods showing significant improvement classification performance benchmark tasks kernel methods shown empirically results achieved either better competitive leading benchmarks support vector machines deep models
psoriasis treatments range topical treatments phototherapy oral systemic medications injections despite good control disease applying appropriate treatments according disease severity insurance parameters patient preference patients ability adhere continued advancements allow even better symptomatic control reduced adverse effects patient satisfaction review aims assess traditional new psoriasis treatments apply clinical practice literature review psoriasis treatments clinical applications performed using pubmed mild moderate psoriasis treatments include topicals localized phototherapy newer therapies combining two types topicals phototherapy topicals easy use foam spray vehicles moderate severe psoriasis therapies include monotherapy various combinations generalized phototherapy oral treatments biologic agents new oral biologic agents horizon dermatologists primary care providers share roles screening associated comorbidities including cardiovascular disorders chronic kidney disease crohn disease dyslipidemia diabetes mellitus insulin resistance depression metabolic syndrome obesity psoriatic arthritis managing patients treatments reevaluating treatment needs new therapies approved continued advancements psoriasis treatment improvement coordinated care allow better overall care patients psoriasis
distinct explicit implicit memory processes support weight predictions used lifting objects making perceptual judgments weight respectively first time object encountered weight predicted basis learned associations priors linking size material weight fundamental question whether brain maintains single global representation priors multiple representations updated context specific way second key question whether updating priors ability scale lifting forces repeatedly lifting unusually weighted objects requires focused attention investigate questions compared adaptability weight predictions used lifting objects judging weights different groups participants experienced size weight inverted objects passively objects placed hands actively participants lift objects full divided attention assess weight judgments measured size weight illusion every trials experience inverted objects passively actively attenuation illusion arises lifting inverted object found context specific attenuation larger mode interaction inverted objects matched method assessment illusion dividing attention interaction inverted objects effect attenuation illusion slow rate lifting forces scaled weight inverted objects findings suggest brain stores multiple representations priors context specific focused attention important scaling lifting forces updating weight predictions used judging object weight elsevier rights reserved
background burkittlymphoma common childhood cancer cameroon reported incidence per children years northwest region treatment three baptist mission hospitals recorded cure rate traditional medicine recognized national health system scope undefined entraps children aim study investigate attitudes practices parents traditional healers towards children order develop recommendations integrative approach improved access life saving treatment children methods descriptive case series children diagnosed treated banso mbingo mutengene baptist hospitals questionnaire used obtain following information demographic information religion rate use reasons guardians chose use diagnoses made treatment offered type payment requested based accounts patient caregivers data analyzed using center disease control epi info results three hundred eighty seven questionnaires completed parents guardians consulted consulted first choice common diagnoses provided included liver problem abscess witchcraft poison hernia side pain mushroom belly toothache methods management included massage cuts concoctions incantations fee services included chickens farm tools cash ranging fcfa usd fcfa usd choice based accessibility failed clinic hospital attendance recommendation relatives belief conclusions involved management cameroon ignorant resulting non referral thus delay diagnosis treatment collaboration could reduce late diagnosis improve cure rates childhood cancers
context people living human immunodeficiency virus hiv plwh risk falling hiv primary care detectable viral loads include homeless unstably housed individuals codiagnosed behavioral health disorders patient centered medical home pcmh model promotes provision comprehensive patient centered accessible coordinated quality care patients initiative provided patient navigation hiv positive homeless unstably housed individuals codiagnosed mental health substance use disorder means create adapted pcmh meet specific needs population objective purpose analysis characterize roles responsibilities patient navigators part effort create medical home homeless unstably housed plwh behavioral health comorbidities design eighty one depth interviews clinic staff focus groups patient navigators conducted content analysis performed identify key roles responsibilities patient navigators results patient navigators played important role creating pcmh working clients schedule complete appointments develop comprehensive care plans forging critical relationships providers within outside health care systems providing holistic support increase patient self management assisting achieving housing stability conclusions may necessary adapt traditional pcmh model effectively meet social behavior health medical needs homeless unstably housed plwh behavioral health comorbidities patient navigator invest time supporting connecting patients needed services may key component creating effective pcmh population findings highlight roles tasks patient navigators may contribute developing pcmh specific homeless unstably housed plwh mental health substance use comorbidities implementation model potential improve health outcomes retention care viral suppression particularly vulnerable plwh thereby reduce burden hiv infection
leptospirosis common condition wallis futuna definitive diagnosis needs established urgently first patient consultation usually one two days onset clinical signs diagnostic aid composite index established based data patients seen wallis futuna admissions services data taken account include age sex patient home island consultation period results leukocytes platelets crp creatinine ggt tests combined major clinical signs headache conjunctival suffusion threshold limits defined index indicates low risk almost certain biologically confirmed leptospirosis febrile diseases responsible thrombocytopenia found wallis futuna probably explains good statistical qualities index value area curve equal
data deluge accelerates data produced remains locked deep web databases linked open data benefit potential represented huge amount data crucial come solutions expose heterogeneous databases linked data xrrml mapping language endeavor towards goal designed map various types databases rdf flexibly adapting heterogeneous query languages data models remaining free specific language extends rrml recommendation mapping relational databases rdf relies rml handling various data formats paper present xrrml analyse data models several modern databases well format query results returned show xrrml translates result data element rdf relying existing languages xpath jsonpath necessary illustrate features xrrml generation rdf collections containers ability deal mixed data formats also describe real world use case applied xrrml build skos thesaurus aimed supporting studies history zoology archaeozoology conservation biology
context synthetic cannabinoids scs recently become one abused substances among young population caused severe health consequences country worldwide objective aim study investigate sociodemographic dermatological findings addicts materials methods total users applied hospital substance dependence center outpatient clinic diagnosed drug addiction according dsm criteria september september enrolled study patients evaluated dermatologist psychiatrist sociodemographic clinical data sheets data obtained direct conversation patients clinical examination findings laboratory tests necessary results patients female male aged mean age common use way smoking patients majorly used opiates majority patients enrolled study low educated almost regular job frequent dermatologic complaints periorbital darkening hallowed cheeks premature aging hair loss gray hair acnes whereas frequent dermatologic examination findings artifact lesions blade scars tobacco scars stains tattoos acnes discussion conclusions given increased prevalence use country around world dermatologists continue familiarize common mucocutaneous markers substance use awareness signs scs use facilitate earlier diagnose intervention directed treatment
recent food safety scandals taiwan caused panic among taiwanese public become primary concern foods discovered containing dangerous amount illegal additives theory planned behavior tpb model extremely useful predicting people food choices consumption habits study included examination public attention perceived credibility mass media food safety information perceived risk background factors extended tpb model predict public intention take precautions avoid consuming foods additives empirical results structural equation modeling analysis useful samples revealed extended tpb model increased explanatory power relative original model regarding intention public taiwan take precautions avoid consuming foods contain additives addition attitudes toward perceived behavioral control consumption food additives impact risk perceptions plays important role determining individual intention take precautions avoid consuming foods contain additives attention individual food additive scandal news perceived risk determine attitude toward consuming food additives individual perceived risk consuming food additives determined attention paid food additive scandal news perceived credibility news elsevier ltd rights reserved
paper sensitivity look ahead economic dispatch real time power markets respect data perturbation studied look ahead dispatch optimization problem small change data used setting interspatial temporal equality inequality constraints objective function may negatively affect normal operations calculation real time wholesale electricity prices operating costs could lead distorted prices larger operating costs look ahead dispatch static dispatch use data single future time perturb karush kuhn tucker conditions look ahead dispatch optimization formulation using derive linear sensitivity matrix assesses impact data corruption look ahead dispatch matrix illustrates changing optimal solution look ahead dispatch subject potential corruption various types spatial temporal data generator bidding cost coefficients capacity limits generators transmission lines ramp rates estimate initial generation output ramp constraints multiple time series forecast load look ahead horizon results simulation illustrated numerical examples ieee bus system
amount electrical energy used interior lighting medium large buildings generally considerable european standard devised establish conventions procedures estimation energy requirements lighting buildings energy performance numeric indicator methodology based three derating factors consider influence daylight exploitation occupancy behavior present constant illuminance sensor factors evaluated statistical approach basis general reference data tabulated standard considering detailed parameters control system impact severely effective energy savings standard methodology appears extremely useful preliminary evaluation accurate evaluation paper suggests improvement procedure considers effective operation time occupancy behavior type control lamps number control groups technique modulation dimming switching delay turning suggested procedure compared standard one highlight improvements
study conducted assess physicochemical changes overall nutritional implications greenhouse grown megaton yureka tomato cultivars vine postharvest ripening conditions first group tomatoes harvested vine breaker pink red ripening stages sampled immediately second group harvested breaker stage allowed ripen room conditions pink red stages based color values similar vine ripened samples results present study revealed fresh weight loss maximum acceptable weight loss firmness minimum limit marketing postharvest ripening pink red stages moreover process deleterious effect antioxidant properties antioxidant activity tomatoes hence results clearly indicate breaker stage tomatoes postharvest ripened room conditions without affecting marketability nutritional components
paper presents novel statistical characterization indoor low voltage narrowband power line communication plc channel cenelec fcc arib bands experimental measurements electrical network complex transfer functions used determine frequency range khz statistics average channel gain delay spread parameters coherence bandwidth channel capacity average measured channel attenuation exhibits values mean frequency band khz root mean square rms delay spread mean value channels revealing values minimum coherence bandwidth correlation level khz mean channel capacity mbps lognormal behavior confirmed justified rms delay spread average channel gain negative correlation two parameters examined relationships different studied metrics also explored
control systems heating ventilation air conditioning non domestic buildings often operate fixed schedules assuming maximum occupancy business hours since lower occupancies usually mean less demand heating ventilation air conditioning energy savings could made air quality sensing often combined temperature sensing performed sufficiently past maintained properly although sensor control failures may increase energy use much energy costs increase coupled increased complexity building services reduced commissioning time placing ever higher demands sensing building controls must meet increasingly stringent environmental requirements whilst also improving reliability sensor fusion offers performance resilience meet demands cost privacy key factors also met article describes neural network approach sensor fusion occupancy estimation feature selection carried using symmetrical uncertainty analysis fusion sensor features used back propagation neural network occupant count accuracy exceeding
background apoptosis inhibitor macrophages aim initially identified apoptosis inhibitor supports survival macrophages various apoptosis inducing stimuli aim produced macrophages may contribute pathogenesis inflammatory bowel diseases ibds however reports kinetics aim ibd impact aim pathogenesis ibd study aimed investigate diagnostic utility levels aim correlation activity crohn disease ibd methods used enzyme linked immunosorbent assay elisa examine aim serum levels healthy subjects patients inflammatory bowel diseases namely ulcerative colitis well patients behcet disease intestinal disease controls compared serum aim levels among groups examined whether correlations serum aim levels disease activity type also performed immunohistochemical staining aim intestinal tissues patients results serum aim levels significantly higher patients patients controls respectively difference serum aim levels treatment patients however patients diagnostic rate using aim better based anti saccharomyces cerevisiae antibodies aim expressed macrophages positive intestinal tissues patients conclusions aim novel biomarker distinguish suggested aim may contribute intestinal inflammation inhibiting apoptosis macrophages
essay analyze three plays spanish writer lourdes ortiz yudita cenicienta aquiles pentesilea goal exploring author intriguing reconsideration power structures configuration gender roles engaging modern interpretation three myths three works writer examines way male female relations shaped suggesting mainly aquiles pentesilea need adopt egalitarian models identity may positive effect society lead greater well female male subjects ipa
test oracle determines whether test execution reveals fault often comparing observed program output expected output always practical example program input output relation complex difficult capture formally metamorphic testing provides alternative correctness determined checking individual concrete output applying transformation test input observing program output morphs different one result since introduction metamorphic relations many contributions metamorphic testing made technique seen successful applications variety domains ranging web services computer graphics article provides comprehensive survey metamorphic testing summarises research results application areas analyses common practice empirical studies metamorphic testing well main open challenges
distribution power systems vulnerable instability destabilizing effect converter controlled constant power loads cpls input filters standard stability analysis tools based averaging linearization techniques used switching frequency converter significantly higher cutoff frequency filter however distribution systems reduced size filter consequently high cutoff frequency common transportation applications conventional methods fail detect instabilities system take account switching effect overcome drawback paper proposes discrete time method analyze stability distribution systems model applied power system cpl switching effects nonlinearities system model taken account simple discretization approach proposed method able predict dynamic properties system slow scale fast scale instabilities active stabilizer also included system model order extend stability margin system finally observations validated experimentally laboratory test bench
multi objective optimization problem applied electric machine design new robust surrogate assisted algorithm proposed research proposed algorithm find robust well distributed pareto front set rapidly precisely robust nondominated solutions using kriging surrogate model uncertainty consideration worst case scenario outstanding performances proposed algorithm verified test function furthermore application optimal design process interior permanent magnet synchronous motor feasibility algorithm verified
skilled human full body movements often planned highly predictive manner example walking reaching towards goal object steps body postures adapted goal position already multiple steps goal contact realization highly predictive behaviors humanoid robots challenge standard approaches optimal control result computation times prohibitive predictive control complex coordinated full body movements multiple steps devised new architecture combines online planning complex coordinated full body movements based flexible combination learned dynamic movement primitives walking pattern generator wpg based model predictive control mpc generates dynamically feasible locomotion humanoid robot hrp dynamic filter corrects zero moment point zmp trajectories order guarantee dynamic feasibility executed behavior taking account upper body movements time ensuring accurate approximation planned motion trajectories demonstrate high flexibility chosen movement planning approach accuracy feasibility generated motion addition show approach generates adaptive motion using machine learning methods interpolation feasible training motion examples fails guarantee stability dynamic feasibility generated behaviors elsevier rights reserved
aim little information relationship uric acid residual renal function rrf continuous ambulatory peritoneal dialysis capd aim research study influence rrf decline capd patients methods retrospective observational cohort study patients started capd without anuria conducted single medical center outcomes measured study included rate rrf decline anuria multiple ordinal logistic regression model backward elimination conducted determine independent factors slope rrf decline cox proportional hazard model conducted determine independent variables time anuria results average rate rrf decline min per month multivariate analysis showed lower group mmol higher group mmol male gender diabetes mellitus use calcium channel blocker ccb rrf baseline linked positively rate rrf decline hand independence dialysate exchanges bun negatively associated risk rrf decline addition male gender diuretics ccb associated higher risk progression anuria whereas urine amount baseline conferred protective role development anuria conclusions shaped relationship found levels rate rrf decline patients capd faster decline rate higher lower groups
recent theoretical model suggests intraspecific competition important determinant severity inbreeding depression reason intraspecific competition density dependent leading stronger negative effect inbred individuals weaker competitors outbred ones support prediction previous empirical work shows inbred individuals weaker competitors outbred ones intraspecific competition often exacerbates inbreeding depression report experiment burying beetle nicrophorus vespilloides recorded outcome competition small vertebrate carcass inbred outbred male resident caring brood size matched inbred outbred male intruder found inbred males successful intruders taking carcass male resident injured frequently either residents intruders furthermore inbred males gained less mass breeding attempt shorter adult life span outbred males finally successful resident males reared substantially smaller brood comprised lighter larvae intruder inbred outbred results shows inbred males increased competitive effort thus contradicting previous work suggesting inbred males weaker competitors furthermore results shows inbred intruders impose greater cost resident males suggesting outbred individuals suffer fitness costs result competition inbred ones
aim paper present mobile agents model distributed classification big data great challenge optimize communication costs processing elements pes parallel distributed computational models way ensure scalability efficiency method additionally proposed distributed method integrates new communication mechanism ensure hpc high performance computing parallel programs distributed one means cooperative mobile agents team uses asynchronous communication ability achieve mobile agents team implements distributed method fuzzy means algorithm dfcm performs big data classification distributed system paper shows proposed scheme assigned dfcm algorithm presents experimental results illustrate scalability efficiency distributed method
speckle reduction prerequisite many image processing tasks synthetic aperture radar images well coherent images recent years predominant state art approaches despeckling usually based nonlocal methods mainly concentrate achieving utmost image restoration quality relatively low computational efficiency therefore study aim propose efficient despeckling model high computational efficiency high recovery quality end exploit newly developed trainable nonlinear reaction diffusion tnrd framework proven simple effective model various image restoration problems original tnrd applications diffusion network usually derived based direct gradient descent scheme however approach encounter problem task multiplicative noise reduction exploited study solve problem employed new architecture derived proximal gradient descent method taking account speckle noise statistics diffusion process despeckling task derived retrain model parameters presence speckle noise finally optimized nonlinear diffusion filtering models obtained specialized despeckling various noise levels experimental results substantiate trained filtering models provide comparable even better results state art nonlocal approaches meanwhile proposed model merely contains convolution linear filters image offers high level parallelism gpus consequence images size gpu implementation takes less produce state art despeckling performance
algebraic algorithmic study integro differential algebras operators started past decade integro differential operators allow particular study initial value boundary problems linear odes algebraic point view differential operators already provide rich algebraic structure wealth results algorithmic methods adding integral operators evaluations many new phenomena appear including zero devisors non finitely generated ideals tutorial give introduction symbolic methods integro differential operators boundary problems developed last years particular discuss normal forms basic algebraic properties computation polynomial solutions ordinary integro differential equations polynomial coefficients also outline methods manipulating solving linear boundary problems illustrate implementation
present study sought examine relationships two language assessments psychometrically validated adaptive behavior scale assessments evaluated included promoting emergence advanced knowledge relational training system direct training module peak assessment basic language learning skills revised ablls vineland adaptive behavior scales second edition vabs assessments completed children diagnosed autism results indicate significant correlation scores peak ablls peak vabs well ablls vabs results indicate ceiling effects amongst assessments results extend research psychometric properties assessment tools provide implications practitioner choice curricula
hybrid approach proposed conceptual design blanket firstly neutron wall loading nwl blanket module obtained neutronics calculation employing model contains geometry outline vacuum vessel components exact neutron source distribution secondly cylindrical model blanket module containing detailed radial building adopted neutronics analysis aim calculating tritium breeding ratio tbr nuclear heating normalized nwl nuclear heating transferred model thermal hydraulics analysis using fluent code series analysis nuclear thermal iterations considers tritium breeding ratio tbr thermal performance optimization objectives optimized radial building module surrounding plasma obtained thirdly structural design module established adding side walls cover plates stiffening plates components based radial building neutronics thermal hydraulics using detailed blanket modules analyzed approach successfully applied design water cooled ceramic breeder blanket chinese fusion engineering test reactor cfetr radial building blanket module surrounding plasma optimized global tritium breeding ratio tbr calculated neutronics analysis temperature materials blanket structure upper limits indicated comparison neutronics thermal hydraulics analyses front zones adjacent plasma present larger deviations nuclear heat namely tungsten respectively breeder zones influence overall temperature achieve significantly smaller deviations less temperature model front breeder zones consistent results model deviation largest deviation occurs back breeder zone manifolds arranged blanket model makes temperature breeder much lower results provide useful reference optimization design elsevier rights reserved
background hiv transmission result complex dynamics risk behaviors partnership choices disease stage position along hiv care continuumindividual characteristics change time capturing dynamics simulating transmissions understand chief sources transmission remain important prevention methods progression transmission hiv aids path agent based model sample people living hiv plwh represent men sex men msm heterosexuals living hiv persons uninfected modeled populations stratified risk gender model included detailed individual level data several large national surveillance databases outcomes focused average annual transmission rates disease stage hiv care continuum sexual risk group results relative risk transmission acute phase nine times percentile simulation interval non acute phase although average acute infections comprised plwh relative risk transmission times high non acute phase achieved viral load suppression compared relative risk transmission among msm times heterosexuals men sex men women generated sexually acquired transmissions among heterosexuals conclusions model results support continued focus early diagnosis treatment adherence art emphasis prevention efforts msm subgroup appear play role transmission heterosexuals
surgical trauma temporalis muscle potential cause post craniotomy headache temporomandibular disorders tmd aim study evaluate prevalence pain masticatory dysfunction trigeminal somatosensory abnormalities patients acquired aneurysms following pterional craniotomy fifteen patients evaluated surgical procedure trained dentist evaluation consisted research diagnostic criteria tmd standardized orofacial pain questionnaire systematic protocol quantitative sensory testing qst trigeminal nerve pterional craniotomy subjects patients developed orofacial pain triggered mandibular function pain intensity measured using visual analog scale vas mean pain intensity prevalence masticatory dysfunction significant reduction maximum mouth opening sensory evaluation showed tactile thermal hypoesthesia area pterional access patients high frequency temporomandibular dysfunction postoperative orofacial pain trigeminal sensory abnormalities findings help understand several abnormalities contribute postoperative headache orofacial pain complaints pterional surgeries
consider coupled linear system partial derivative partial derivative xxxx gamma partial derivative partial derivative epsilon partial derivative partial derivative partial derivative describing vibrations string beam system related well known lazer mckenna suspension bridge model epsilon decay properties solution semigroup discussed dependence nonnegative parameters gamma responsible damping effects
paper addresses problem state parameter estimation class affine systems state space representation method require specific state representation system consists designing switched observer certain conditions given paper allows state parameter estimation errors converge zero assuming parameters estimated belong given polytope idea method recast parameter estimation problem switching rule design auxiliary switched system whose matrices equilibrium correspond matrices system estimated guaranteed cost used design switching rule based max composition set quadratic functions observation error method simple low computational cost main disadvantage regards amount information needed state parameters estimated simultaneously case parameter estimate method reduces standard luenberger observer guaranteed cost
ultra dense networks promising technology enabling high power spectrum efficiencies future wireless systems well known ultra dense networks inter cell interference one main bottlenecks prohibiting achieving promised performance gains order effectively coordinate mitigate interference paper propose graph based low complexity dynamic clustering algorithm key idea behind proposed algorithm dividing whole network number clusters size constraint maximum intra cluster interference minimum inter cluster interference logic maximum intra cluster effectively controlled coordination within cluster meanwhile graph based algorithm exploited reduce implementation complexity make proposed algorithm suitable practical implementation finally simulation results numerically demonstrate proposed low complexity algorithm almost performance compared existing high performance algorithm complexity much lower
natural gas direct injection ngdi engines attracted attention engine manufacturers low pollutant emissions high efficiency jet structure injector properties control parameters optimal mixture formation stable combustion jet characteristics investigated experimentally natural gas jet injected multi hole injector visualized using schlieren photography effects injection chamber pressures macroscopic jet characteristics examined new correlations tip speed tip penetration presented results show reducing chamber pressure effective injection pressure increasing jet axial penetration moreover linear relation non dimensional tip penetration time dependent chamber toinjected gas density ratio elsevier ltd rights reserved
ecosystem water use efficiency important indicator carbon water cycle coupling study presents new measure water use efficiency soil water use efficiency swue based gross primary production surface soil moisture derived remote sensing products ecv variation swue among biomes climate conditions latitudes comprehensively assessed average global swue year period approximately kgh swue relatively high ecosystems near equator decreased gradually increasing latitude biome level high swue measured evergreen broadleaf forests lower values found shrublands compared two commonly used indicators water use efficiency ewue ratio gross primary production evapotranspiration rue ratio gross primary production precipitation average swue significantly higher largest range values addition spatial distributions three indicators varied greatly new indicator swue help promote understanding soil water use various ecosystems elsevier ltd rights reserved
objectives osteoarthritis common form arthritis affecting approximately human population recently increased concentration nitric oxide serum synovial fluid patients observed however exact role nitric oxide initiation elucidated aim present study investigate role nitric oxide innate immune regulation initiation rats methods rat induced performing meniscectomy surgery cartilage samples collected days surgery cartilage cytokine levels determined using enzyme linked immunosorbent assay proteins assessed using western blot results time course study nitric oxide increased seven days induction pro inflammatory cytokines including tumour necrosis factor tnf alpha interleukin beta decreased nitroarginine methyl ester name non specific nitric oxide synthase inhibitor significantly decreased cartilage nitric oxide blocked immune suppression name decreased matrix metalloproteinase mmps increased tissue inhibitor metalloproteinase timp expression meniscectomised rats conclusion nitric oxide dependent innate immune suppression protects cartilage damage early stages initiation rats
obese smokers diabetes special risk category cause mortality major adverse cardiovascular events mace weight loss smoking cessation key interventions advocated management diabetes almost guidelines across globe however substantial risk weight gain following smoking cessation may cases cause transient worsening glycaemic control people diabetes risk weight gain potential worsening hbac may put obese smokers quit cardiometabolic sequelae smoking cessation people without diabetes different benefit smoking cessation terms reduced cardiovascular cause mortality people without diabetes evident within three years quitting however may take years people diabetes get benefit post cessation weight gain much detrimental obese quitters diabetes without aim review explore best high risk individuals supported remain abstinent long term manage vascular risk profile proactively concerted lifestyle intervention judicious use new novel pharmacotherapy
main aspect database protection prove ownership data describes originator data particular importance case electronic data data sets often modified copied without proper citation acknowledgement originating data set present novel method watermarking relational databases identification proof ownership based secure embedding blind multi bit watermarks using bacterial foraging algorithm bfa feasibility bfa implementation shown framed watermarking databases application identification owner cryptographically made secure used embedded watermark improved hash partitioning approach used independent primary key database secure ordering tuples strength bfa explored make technique robust secure imperceptible bfa implemented give nearly global optimal values bounded data usability constraints thus makes database fragile attack parameters bfa tuned reduce execution time bfa experimentally proved better solution genetic algorithm technique proposed experimentally proved resilient malicious attacks
objective glial fibrillary acidic protein gfap studied many neurological diseases purpose study investigate potential role gfap chinese children autism spectrum disorders asd measuring serum circulating levels gfap comparing age gender matched typical development children methods total one hundred fifty years old chinese children confirmed autism cases age gender matched typical development children participated study serum levels gfap assayed enzyme linked immunosorbent assay methods severity asd evaluated childhood autism rating scale cars score results results indicated mean serum gfap level significantly adjusted multivariate logistic analysis model conclusion data indicates serum gfap levels may associated severity asd among chinese children suggesting hypothesis increased serum levels gfap could implicated pathophjrsiology autism chinese children isdn published elsevier ltd rights reserved
development industry gradual increase population main factors consumption electricity increases order establish good exploitation electrical grid necessary solve technical economic problems done resolution unit commitment problem ucp decisions units commit time period level generate power meeting electricity demand therefore robust unit commitment problem first stage commitment decisions made anticipate worst case realization demand uncertainty minimize operation cost scenarios unit commitment problem allows optimizing combination production units states determining production planning order satisfy expected consumption minimal cost specified period varies usually week however production unit constraints make problem complex combinatorial nonlinear chapter proposed two strategies applied ieee electrical network buses solve ucp general particular find optimized combination scheduling produced power unit production first strategy based hybrid optimization method gradient genetic algorithm second one relies fuzzy logic approach throughout two strategies arrived develop optimized scheduling plan generated power allowing better exploitation production cost order bring total operating cost possible minimum subjected series constraints comparison made test performances proposed strategies prove effectiveness solving unit commitment problems
physical geography evolved become highly productive mainstream natural science delivering metrics required accounting systems dominating neoliberal university argue result crisis production articles capable consuming risk production growing scarcity ability produce research questions needed sustain productivity disciplinary fix involving either pursuit problem solving implicit neoliberal impact agenda creative destruction aligning less geography natural sciences using isabelle stengers critique century science argue slowing physical geography changing relate subjects study use ideas william bunge discuss notion geographical expedition means achieving slow science even expedition term used cautiously illustrate points one projects show slow science may allow creation moments might lead creative critical physical geography centred curiosity makes scientist interesting
researchers believe neurogenesis mature mammals restricted subgranular zone dentate gyrus subventricular zone lateral ventricle central nervous system peripheral nervous system neurogenesis thought active prenatal development exception olfactory neuroepithelium however sensory ganglia adult peripheral nervous system reported contain precursor cells proliferate vitro induced differentiate neurons occurrence insult induced neurogenesis reported several investigators brain limited recent reports peripheral nervous system reports suggest damage adult nervous system induces mechanisms similar control generation new neurons prenatal development understanding conditions neurogenesis induced physiologically non neurogenic regions adults one major challenges developing therapeutic strategies repair neurological damage however induced neurogenesis peripheral nervous system still largely unexplored review presents history research adult neurogenesis peripheral nervous system dates back years reveals evidence estimated potential generation new neurons adult peripheral nervous system
study examines association self reported impulsivity nonsuicidal self injury suicidal ideation suicide attempts completed suicides clinical sample finnish adolescents aged treated psychiatric inpatient care april march schedule affective disorder schizophrenia school age children present lifetime interview used gather information psychiatric disorders impulsivity suicidality adolescents mortality data obtained national cause death register adolescent girls impulsivity significantly associated suicidal ideation attempts completed suicides adolescent boys adolescent boys impulsivity died suicide follow time preventive purposes health care professionals encouraged asked adolescents targeted questions impulsivity consider associated risk suicidality identified study
analog multipliers one important building blocks analog signal processing circuits performance high linearity wide input range usually required analog four quadrant multipliers applications therefore highly linear wide input range four quadrant cmos analog multiplier using active feedback proposed paper firstly novel configuration four quadrant multiplier cell presented input dynamic range linearity improved significantly adding two resistors compared conventional structure based proposed multiplier cell configuration four quadrant cmos analog multiplier active feedback technique implemented two operational amplifiers proposed multiplier cell active feedback technique proposed multiplier achieves much wider input range higher linearity conventional structures proposed multiplier fabricated cmos process experimental results show input range proposed multiplier linearity error linearity error power supply voltages respectively
objectivethe sociocultural attitudes toward appearance questionnaire sataq measure internalization appearance ideals personal acceptance societal ideals appearance pressures pressures achieve societal ideal current study sought address limitations scale order increase precision measurement muscular ideal internalization include assessment one desire attractiveness broaden measurement appearance related pressures methodthe factor structure reliability construct validity sataq revised examined among college women study adolescent girls study college men study resultsfactor analysis among college women indicated factor item scale labeled sataq female internalization thin low body fat internalization muscular internalization general attractiveness pressures family pressures media pressures peers pressures significant others sataq female subscales demonstrated good reliability construct validity among college women examination sataq female among adolescent girls suggested six factor scale peer significant others items comprised single subscale scale demonstrated good reliability construct validity adolescent girls examination sataq among men produced item scale seven factors paralleling factors identified among college women scale labeled sataq male demonstrated good reliability construct validity discussionresults support reliability validity sataq female college women adolescent girls sataq male college men wiley periodicals inc int eat disord
dihydro hydroxy oxo naphthyridine carboxamide derivative recently developed selective cannabinoid receptor compound given high selectivity compound cannabinoid receptor well known protective function receptor neurological disorders autoimmune component like multiple sclerosis assessed immunomodulatory properties assessed activated peripheral blood mononuclear cells proliferation viability cell cycle progression measured activation markers expression phosphorylated proteins found reduces pbmc proliferation slightly affecting cell vitality blocks cell cycle progression regulates levels cell activation markers well expression phosphorylated proteins ikk alpha beta ikb alpha erk akt also used drug permeability assays caco cell line evaluate oral bioavailability mdckii hmdr cell lines estimate propensity cross blood brain barrier passive diffusion order potentially maintain efficiency infiltrating auto reactive lymphocytes central nervous system models showed high intestinal absorption good blood brain barrier penetration findings suggest controlling immune response might find potential application orally administered drug pathologies like multiple sclerosis elsevier societe francaise biochimie biologie moleculaire sfbbm rights reserved
increasing use social interaction contexts cross enterprise manufacturing problem solving transform massive unstructured data decision support information cross enterprise manufacturing demand capability matching present automated solutions two phases extracting relationships based semi supervised learning approach derive formalized heterogeneous manufacturing network unstructured text based context contains high levels noise irrelevant information matching group level relationships among entities established manufacturing network extracting phase formulates network data using multiattributed graph encode various entities relationships matching phase based probabilistic multiattributed graph matching implemented using distributed message passing algorithm developed prototype system verify proposed model also flexible new domains contexts scale large datasets ultimate goal paper facilitate knowledge transferring sharing context cross enterprise social interaction thereby supporting integration resources capabilities among different enterprise
paper analyses one important control system design issues controller performance blending process modeled first order plus dead time selected design closed loop pid controller tuning controller parameters done using ziegler nichols tyreus luyben tuning techniques performance pid controllers evaluated comparing set point tracking disturbance rejection capabilities
software refactoring recognized valuable process software development often aimed repaying technical debt technical debt arises software product built amended without full care structure extensibility refactoring useful keep technical debt low automated obvious efficiency benefits using combination automated refactoring techniques software metrics metaheuristic searches automated refactoring tool improve structure software system without affecting functionality paper four different refactoring approaches compared using automated software refactoring tool weighted sums metrics used form different fitness functions drive search process towards certain aspects software quality metrics combined measure coupling abstraction inheritance fourth fitness function proposed measure reduction technical debt functions compared using different searches different open source programs four programs show larger improvement technical debt function search based refactoring process results show technical debt function useful assessing improvement quality elsevier inc rights reserved
machine learning continuously unleashing power wide range applications pushed forefront recent years partly owing advent big data algorithms never better promised challenged big data big data enables algorithms uncover fine grained patterns make timely accurate predictions ever hand presents major challenges model scalability distributed computing paper introduce framework big data mlbid guide discussion opportunities challenges framework centered follows phases preprocessing learning evaluation addition framework also comprised four components namely big data user domain system phases components mlbid provide directions identification associated opportunities challenges open future work many unexplored explored research areas
paper optimal input load disturbance rejection ildr controller integrating processes dead time proposed based internal model control principle main contribution work optimal solution ildr criterion integrating processes dead time input constant disturbances derived based algebraic theory improve performance set point tracking input disturbance rejection two degree freedom tdof control design method also developed compared previous advanced control methods proposed design method three main advantages first optimal ildr controller derived systematically basis algebraic theory designed controller given analytical form second simple tune principle developed set point tracking performance specification robustness stability specification quantitatively achieved monotonously tuning performance degree designed controller finally optimal set point tracking performance input disturbance rejection achieved proposed tdof control structure numerical simulations given illustrate effectiveness proposed method
objective aim study analyze opinions educators occurrence injuries children different ages organized non organized physical activities kindergarten methods sample included teachers kindergartens slovenia calculated frequencies performed chi square test results children organized physical activity kindergarten times per week children first age group usually lasts minutes less children second age group lasts minutes physical activities take place playroom majority injuries also occur injuries frequently occur running jumping less frequently physical activities free play children often injured outer court boys often injured girls educators indicate unforeseen situations common cause injury common injuries bumps head especially younger children stay home days result injuries parents younger children satisfied actions educators injuries occur parents older preschool children educators rehabilitate children injuries inform parents one third educators make record injuries half serious injury occurred conclusions analysis results showed statistically significant differences children different ages according cause injury time injury place child injured organized physical activity type activity time injury injured part body parental satisfaction action educator based results proposed actions reduce injuries preschool children kindergarten
simple realization bulk driven voltage follower direct current level shifter designed cmos technology presented paper circuit characterized large input output voltage swings voltage gain close unity voltage shift input output terminals regulated certain interval around zero means biasing current sinks application proposed voltage follower circuit realization low voltage class output stage also described paper finally operational amplifier exploiting proposed output stage presented evaluated detail copyright john wiley sons ltd
ever essential hospice palliative care nurse leaders front center quality improvement arena nurses integral delivery hospice palliative care pivotal efforts improve quality article sought provide depth understanding leadership role nurses play activities project inception team formation planning stage analysis revealed hospice palliative care nurses leadership role onset project includes active team membership team leader team member champion nurses also leadership role formulating project aims choosing appropriate project model within organizations finally hospice palliative care nurses use planning skills develop project measures data collection plan data analysis plan communication implementation evaluation plan project provides opportunities hospice palliative care nurse leaders use clinical technical administrative knowledge improve care patients families end life
magnetized plasma two electron temperatures dimensional nonlinear schrodinger equation ion acoustic envelope solitons hereby investigated bright dark soliton solutions obtained found soliton amplitude inversely related respectively coefficients dispersive term nonlinear term combined effect transverse perturbation magnetic field head interactions displayed decreasing transferred overtaking ones bright bound state solitons obtained interaction period decreases increasing head overtaking interactions two dark solitons displayed head interaction transformed overtaking one increasing upon introduction external perturbation developed weak chaos observed phase projections power spectra presented difference two chaotic motions roots inequality nonlinear perturbed terms developed chaos weakened decreasing frequency external perturbation increasing
wavelet transform algorithm emphasized research attention ability study transient signal analysis incredible applications pattern recognition image processing paper mathematical formulations wavelet transform developed multiprocessor applications signal flow graph algorithm designed multiresolution level wavelet transform pow graph modeled implementation multiprocessors connected bruijn graph modeling results derived terms computation time speedup efficiency
although hundreds studies media violence focused literature none examining novels accordingly aim current study examine whether reading physical relational aggression books associated aggressive behavior adolescents participants consisted adolescents completed variety measures detailing media use aggressive behavior non recursive structural equation model revealed reading aggression books positively associated aggressive behavior even controlling exposure aggression forms media associations found congruent forms aggression implications regarding books form media discussed aggr behav wiley periodicals inc
recent research compared numerical efficiency magnetic equivalent circuit mec models based upon kirchhoff voltage law mesh equations kirchhoff current law nodal equations stationary magnetic components shown mesh based methods converge significantly fewer iterations although numerical advantages would seemingly apply electric machines two issues limited application mesh based mec models electric machines movement number meshes unlike number nodes position dependent additionally loss airgap element creates infinite reluctance paper issues addressed specifically first shown relatively straightforward algorithm used dynamically update meshes rotor position addition shown mesh model remains stable large values tube reluctance tube reluctance values large enough cause numerical issues easily avoided excluding narrow range rotor positions based upon results mesh based mec model wound rotor synchronous machine developed shown provide significant advantage nodal based model equivalent
sustainable rural food systems poor vulnerable people need locally adapted enhance food security requires participatory action research considers entire food value chain fvc paper presents assessment feasibility potential success upgrading strategies ups enhancing food security based study part larger participatory research project two regions tanzania authors present results relating natural resource management crop production results natural resources show enhanced soil water management rated high semi arid dodoma region morogoro region experts favoured soil fertility improving ups conservation agriculture agroforestry assessments food production regions indicated importance intercropping manure input pest disease control cover crops assessments differed greatly two different climatic regions lesser extent nationality experts gender highlights importance including different south north female male awareness assessments implementation feasibility assessments ups indicated suitable approaches rainwater harvesting semi arid conservation agriculture subhumid regions respectively local regional stakeholders experts involved developing assessing site adapted ups enhancing tanzanian fvcs
detailed publications allow performing associations technical aspects occurrence injuries purpose study apply methodology based recording material assess injury risk factors common nage waza judo techniques regular training amateur judokas used case study novice students men women university vigo five academic years filmed ordinary training period technical execution ten nage waza techniques obtained data evaluated using descriptive statistics patterns analysis thus possible identify presence typical inaccuracies execution technique uncovering main temporal sequence errors allowing link findings injury occurrence order narrow unexpected causes accidents regarding poor technique performance regular training research provides hidden temporal sequence errors common throw techniques helping professionals correct key technical errors order prevent diverse type injuries methodology developed could easily extended martial sports
atp mortality icd patients aimsantitachycardia pacing atp effective treatment ventricular tachycardia reduce frequency shocks patients implantable cardioverter defibrillator icd association survival atp compared shock confirmed large patient population study aims determine patients icd receiving atp lower mortality compared receiving shock methodssixty nine thousand three hundred sixty eight patients underwent icd implantation october may enrolled remote monitoring network jude medical paul usa patients categorized three groups based type icd therapy received follow therapy atp shock groups survival determined linking implant records social security death index resultsthe therapy hazard ratio confidence interval atp groups associated lower mortality risk shock group results unaffected age gender device type atrial fibrillation burden ventricular rate atp effective episodes atp effectiveness dependent ventricular rate conclusionsmortality rates higher icd patients received atp compared therapy icd patients received shock higher mortality compared groups furthermore data suggest age gender device type burden rate arrhythmia change trend higher mortality patients receiving icd shock compared atp alone
extreme degree parallelism high end computing requires low operating system noise large scale bulk synchronous parallel applications run efficiently noiseless execution historically achieved deploying lightweight kernels lwk hand provide restricted set posix api exchange scalability however increasing prevalence complex application constructs situ analysis workflow composition dictates need rich programming apis posix linux order comply seemingly contradictory requirements hybrid kernels linux lightweight kernel lwk run side side compute nodes recently recognized promising approach although multiple research projects pursuing direction questions node resources shared two types kernels exactly two kernels interact extent integrated remain subjects ongoing debate paper describe ihk mckernel hybrid software stack seamlessly blends lwk linux selectively offloading system services lightweight kernel linux specifically focusing transparent reuse linux device drivers detail design framework enables lwk naturally leverage linux driver code base without sacrificing scalability posix api rigorous evaluation medium size cluster demonstrate mckernel provides consistent isolated performance simulations even face competing situ workloads
study aimed assess influence feed composition onset solid feed intake age growth performance health young rabbits slaughter age rabbit kits issued followed two successive reproduction cycles divided experimental groups differing diet suckling rabbits received age young rabbits group fed diet met needs reproductive lcg young rabbits group fed diet met needs growing rabbits rabbits groups fed diet received diet throughout experiment thanks experimental cages allow separate feeding mothers litters groups feed offered libitum weaning age restricted weaning feed intake animal weights health status recorded weekly mortality recorded daily feed intake higher group group feed intake similar groups kit resulted higher average daily gain higher weight weaning group compared group difference live weight two groups reduced due lower feed conversion rate group mortality low weaning differences seen groups concerning mortality morbidity support hypothesis suckling rabbits regulate feed intake based energy content diet onset solid feed intake suggests moment distribution fattening feed weaning impact weight weaning kit health fattening period elsevier rights reserved
aim study assess increase temperature following laser irradiation diode laser wavelengths implant conditions closely replicate human body machined surface implant placed porcine rib replicate conductivity heat given bone peri implant vertical defect made wide deep simulate bone resorption two thermocouples positioned crestally apically implant surface tip laser kept away surface continuously moved side side fashion inside defect seconds initial temperatures time needed reach increase degrees recorded experiment repeated room temperature degrees water bath following settings continuous repeated pulsed critical increase temperature degrees reached lasers continuous mode room temperature diode laser reached critical increase win pulsed mode critical increase temperature registered settings bone block placed degrees water bath results study suggest use diode lasers cause harmful increase temperature used conditions similar human body
psoriasis chronic inflammatory disease appearing scaly erythematous cutaneous lesions characterized parakeratosis acanthosis well infiltration immune cells helper helper cells demonstrated kdpt tripeptide structurally related terminal amino acids alpha melanocyte stimulating hormone previously shown exhibit anti inflammatory effects intestinal inflammation ameliorated ongoing disease mouse model imiquimod induced psoriasis like skin inflammation small xenotransplant mouse model psoriasis could show systemic kdpt treatment significantly reduced hyperkeratosis acanthosis murine well human skin moreover kdpt upregulated foxp cells mice peripheral blood individuals psoriasis decreased expression type inflammatory cytokines indicating beneficial effect kdpt least part mediated induction functional regulatory cells suppressed activation pathogenic ifn cells thus data might suggest kdpt potential novel therapeutic alternative treatment psoriasis
glucokinase hexokinase unique hexokinase plays central role mammalian glucose homeostasis glucose phosphorylation pancreatic beta cell rate limiting step controls glucose stimulated insulin secretion similarly mediated glucose phosphorylation hepatocytes plays major role increasing hepatic glucose uptake metabolism possibly lowering hepatic glucose output small molecule activators gkas identified increase enzyme activity binding allosteric site gkas offer novel approach treatment type diabetes mellitus tdm garnered much attention report design synthesis biological evaluation novel series trisubstituted indole derivatives act highly potent gkas among compound found possess high vitro potency excellent physicochemical properties good pharmacokinetic profile rodents oral administration compound doses low led robust blood glucose lowering efficacy week high fat diet fed mice published elsevier ltd
electrical circuits connect biosensors actuators plants trees many electrochemical components devices plants created nature memristors participate electrical signal transduction phytosensors actuators electrical processes play important roles physiology plants trees fruits seeds electrical form energy entropy content used work information transfer computing analysis signals propagate along sophisticated electrical circuitry plants consisting many electrical components cell computing system decision making processes action potentials mediators intercellular intracellular communication response environmental stresses graphics
flash floods among severe hazards disastrous environmental human economic impacts study interested characterization flood hazard gabes catchment southeastern tunisia considered important step flood management region analytical hierarchy process ahp geographic information system applied delineate characterize flood areas spatial database developed based geological map digital elevation model land use rainfall data order evaluate different factors susceptible affect flood analysis however uncertainties associated ahp techniques may significantly impact results flood susceptibility analyzed function weights using monte carlo simulation global sensitivity analysis ahp ahp models gave similar results however compared ahp approach ahp confidence intervals overall scores small overlaps results obtained validated remote sensing data zones showed high flood hazard extreme rainfall event june hit study basin
advances understanding human pain experience shifted much focus pain research periphery brain current hypotheses suggest progression migraine depends abnormal functioning neurons multiple brain regions accordingly sought capture functional brain changes induced application inflammatory cocktail known inflammatory soup dura mater across multiple brain networks specifically aimed determine whether alters additional neural networks indirectly related primary nociceptive pathways via spinal cord thalamus cortex comprises acidic combination bradykinin serotonin histamine prostaglandin pge introduced basic pain research tool activate sensitize peripheral nociceptors studying pathological pain conditions associated allodynia hyperalgesia using model intracranial pain found dural application awake fully conscious rats enhanced thalamic hypothalamic hippocampal somatosensory cortex responses mechanical stimulation face compared sham synthetic interstitial fluid administration furthermore resting state mri data revealed altered functional connectivity number networks previously identified clinical chronic pain populations included default mode sensorimotor interoceptive salience autonomic networks findings suggest activation sensitization meningeal nociceptors enhance extent brain processes nociceptive signaling define new level modulation affective cognitive responses pain set new tone hypothalamic regulation autonomic outflow cranium change cerebellar functions published elsevier
paper focuses stabilization problem floated inertial platform experimental system based moment analysis platform mode main moment dynamic equation stabilized platform rotating around center derived consideration disturbances solve system model uncertainty measurement noise three axial coupling unmodeled disturbances auto disturbances rejection controller adrc proposed addition time delay problem caused system wireless transmission addressed using improved adrc controller three axial stabilized control system model floated inertial platform experimental system built matlab simulink simulations indicate adrc controller better traditional pid controller controller stabilize platform quickly accurately robustly without overshoot improved smith predicting adrc controller eliminate influence transmission time delay system realize stability control real timely virtue improved controller platform provide effective inertial reference vehicle
objectives faculty sexual reproductive healthcare fsrh recommended emergency contraception health professional discuss individual needs inform women different methods efficacy adverse effects interactions eligibility additional contraception sexual reproductive health care service liverpool knowsley revised guidance issued early reflecting faculty advice studied use changed methods offered changed method chosen women offered three licensed methods appropriateness offer levonorgestrel lng methods studied total case records months months following adoption service fsrh guidance retrospective review charts undertaken interrogating computerised excelicare system clinical records episodes two month periods analysed covering october december march may additionally three non probabilistic purposeful samples representative practitioners charts examined groups women offered methods choosing either ulipristal acetate upa lng offered lng results use lng fell issued upa use rose second month period women offered three methods chose lng upa lng offers judgement clinically appropriate cases offers conclusions comparing second period first women offered three methods use lng fell upa increased women encouraged exercise choice however increasing choice service lead wholesale change lng upa
large number diseases occurring desmosome constituents impaired provides striking evidence key role desmosomes maintaining tissue integrity detailed understanding molecular alterations causing desmosomal dysfunction turn underpinned development novel diagnostic tools salient clinical implications dentists oral medicine practitioners majority desmosomal diseases affect oral cavity present article review autoimmune infectious genetic neoplastic diseases target desmosome particular emphasis clinical manifestations diagnostic pathways relevant laboratory investigations
background collaborative virtual environments cves potential support sociocommunicative interactions people autism spectrum disorder asd little known sense presence participants feel cves cves used assess skills method ten children asd typically developing children aged years judged greeting behaviours human avatar static facial expressions virtual gallery results differences presence reported two groups asd group less sensitive negative greeting human avatar group impaired recognising static facial expressions conclusions self reported measures presence valuable informing kinds tasks technology may provide authentic contexts identify support social competence participants asd
supervisory control ensures deadlock free nonblocldng operation active research area manufacturing engineering far deadlock control policies existing literature assume allocated resources reliable additionally large number methods systems simple sequential processes resources prs part uses one copy one resource processing step contrast investigate automated manufacturing systems amss modeled class petri nets namely spur spur generalization petri net model superclass spr work addresses robust supervision deadlock avoidance spur specifically take account unreliable resources may break working idle considered amss allow use multiple copies different resources per operation stage objective control system breakdowns system continue producing parts types whose production need failed resources given correction faults possible complete going part instances remaining system illustrate characteristics desired supervisor several examples define corresponding properties robustness develop control policy satisfies properties elsevier ltd rights reserved
paper new approach based continuum model proposed estimate main cable tension force suspension bridges measured natural frequencies approach considered vertical vibration main cable hinged towers supported elastic girder hangers along entire length equation reflected relationship vibration frequency horizontal tension force main cable derived avoid generate additional cable tension force sag extensibility analytical solution characteristic equation anti symmetrical vibration mode main cable calculated estimation main cable tension force carried anti symmetric characteristic frequency vector errors estimation due characteristic frequency deviations investigated numerical analysis main cable taizhou bridge field experiment conducted verify proposed approach measuring analyzing responses main cable taizhou bridge ambient excitation horizontal tension force main cable identified first three odd frequencies shown estimated results agree well designed values proposed approach used conduct long term health monitoring suspension bridges
light growing role social media conflict management current study analyzes interrelationship online political participation israeli jews frequency online contacts arabs jews perceived social distances arabs research conducted online survey representative sample israeli jews use social media least times week overall although causation inferred correlational design study results suggest frequency online contacts may positively affect closeness arabs line contact theory keeping socialization perspective political engagement findings indicate impact online political participation social distances arabs mediated interactions jews arabs social media
patients advanced parkinson disease eligible deep brain stimulation dbs referred specialized centers survey evaluated reasons reluctance patients referring physicians regarding dbs two different questionnaires containing multiple choice open verbalized questions developed one neurologists one patients first questionnaire sent neurologists private practice catchment area authors medical center second patient support groups region help german parkinson association addressed neurologists completed questionnaire estimated risk intracerebral hemorrhage severe complication average concerned patients developing mood changes depression dbs felt unable care patients dbs already personal experience patients dbs reported good clinical outcome patients although claimed know specific criteria dbs could actively describe could state three main criteria patients completing questionnaire obtained information dbs regional patient organizations also physician assumed risk severe complications satisfied medical treatment reported considered dbs treatment option latter numbers indicate treating neurologists tend overestimate reluctance patients undergo dbs therefore education patients neurologists improved give realistic figures actual outcomes frequencies possible complications
background purpose epidemiological studies men suggest relationship endogenous testosterone ischemic vascular events hypothesized low testosterone independently associated ischemic stroke ischemic brain changes methods male participants mean age years body mass index visit aric study atherosclerosis risk communities without cardiovascular disease stroke previous testosterone therapy measured plasma total testosterone liquid chromatography mass spectrometry using morning samples divided levels tertiles median percentile general linear models cross sectional analyses proportional hazards regression time event analysis examined association testosterone participant characteristics incident stroke linear logistic regression models examined association testosterone percentage white matter hyperintensities prevalent infarcts participants underwent brain magnetic resonance imaging visit analyses adjusted age race aric center body mass index waist circumference smoking status diabetes mellitus hypertension low density lipoprotein high density lipoprotein results lower testosterone significantly associated higher body mass index greater waist circumference diabetes mellitus hypertension lower high density lipoprotein never smoking adjustment association testosterone incident stroke found hazard ratios confidence intervals tertile versus median follow years percentage white matter hyperintensities cortical infarcts subcortical infarcts conclusions controlling atherosclerotic risk factors association endogenous testosterone incident clinical stroke ischemic brain changes community dwelling men
article present hybrid method improve performance montgomery reduction taking advantage karatsuba technique divide montgomery reduction two sub parts including one conventional montgomery reduction one karatsuba aided multiplication approach reduces multiplication complexity limb montgomery reduction theta asymptotic complexity theta practical implementation results bit microcontroller also show performance enhancements
background prednisone dependence asthma usually described based clinical spirometric characteristics generally believed patients frequent exacerbations lose lung function rapidly uncontrolled airway eosinophilia objectives objectives study report effect asthma exacerbations change lung function time prednisone dependent asthma severe asthma managed using protocol aims maintain normal sputum cell counts methods retrospective survey patients prospectively assessed university tertiary care asthma clinic results patients males mean age years non atopic followed median period years min max monitoring aim keeping sputum eosinophils resulted higher doses corticosteroids median daily dose prednisone inhaled corticosteroids fluticasone equivalent baseline associated predictable adverse effects despite disease severity patients require laba symptom control importantly period follow eosinophilic exacerbations patient year overall increase fev period follow mean year rather expected decline conclusions monitoring eosinophils sputum enables maintain symptom control preserve fev patients severe prednisone dependent asthma
article new active elements current follower transconductance amplifier cfta current mirror inverter cmi realization current mode analog blocks presented proposed internal bipolar structure cfta presented usage active element shown design universal simo single input multi output type frequency filter working current mode frequency filter emloying cfta cmi elements synthesized using signal flow graphs filter enables realizing basic functions low band high pass also band stop pass responses properties filter proposed verified sensitivity analyses pspice program
manuscript deals compact setup photometric determination chemical species requiring heating step prior measurement setup consists flow batch device led based photometer flow batch device machined stainless steel piece designed used analytical procedures without requiring use fluid heat exchange resistive heating element temperature sensor embedded holes perforated stainless steel device allowing temperature control performed software aliquots sample reagent solution inserted heated cavity using solenoid valves controlled software reaction development proceeded compound formed monitored using homemade led based photometer coupled flow batch device optical fiberglass cable steps analytical procedure performed employing microcontroller pic effectiveness proposed flow batch device evaluated using photometric determination manganese plant materials accuracy assessed comparing results achieved using reference method significant difference confidence level observed useful features analytical throughput determinations per hour linear response ranging relative standard deviation reagent consumption naio waste generation per determination achieved elsevier rights reserved
web news articles generated continuous time varying rapid modes environment causes explosion information needs stored processed analyzed conventional machine learning algorithms applied web news mining work offline environment efficiently handle data streams paper propose evolving web news mining framework based recently published evolving type classifier etclass etclass adopts open structure used non stationary environments works single pass learning mode applicable online real time applications effectiveness evolving web news mining techniques numerically validated compared state art algorithms efficacy methodology numerically validated real local australian news articles namely age spanning compared state art algorithms algorithm outperforms consolidated algorithms achieves tradeoff complexity accuracy almost improvement term complexity published elsevier
purpose review purpose review identify emerging developmental toxicants understudied children health exposures may arise new products designed improve utility reduce toxicity replace undesirable chemicals exposures less toxic chemicals may also significant commonly used thereby generating widespread exposure sources exposure include workplace personal home office products food water air recent findings describe eight exposure categories contain numerous potential developmental toxicants references discussed reported pubmed past decade least times frequently examples included phthalates phenols sunscreens pesticides halogenated flame retardants perfluoroalkyl coatings nanoparticles cigarettes dietary polyphenols replacements often close structural homologs precursors suggest biomonitoring preferred means exposure assessment emerging chemicals existing analytic methods would require minimal modification measure exposures others require toxicokinetic analytic investigation summary deliberate strategy biomonitoring emerging replacement chemicals warranted especially view concerns regarding developmental toxicity prevent adverse health effects important characterize exposures become widely disseminated
air pollution major environment related health threat studies toxicity verified cardiovascular system endothelial cells however researches induced myocardial related toxicity limited study aims fully understand toxic effects human myocardial cell explore molecular mechanism based microarray analysis bioinformatics analysis microarray data analysis manifested induced toxicity affected expression genes compared control group including upregulated genes downregulated genes human myocardial cells analysis showed cellular processes immune response cell maturation embryonic heart tube morphogenesis cellular response electrical stimulus skeletal muscle tissue regeneration negative regulation signal transduction upregulated regulation transcription dna dependent rhythmic process protein destabilization apoptotic process innate immune response downregulated pathway analysis indicates cell signaling pathways cytokine cytokine receptor interaction kappa signaling pathway chemokine signaling pathway endocrine factor regulated calcium reabsorption htlv infection cell adhesion molecules cams upregulated tgf beta signaling pathway downregulated addition signal net showed tubaa adrbk brix smc eifb prmt atgb ndc genes significantly decreased expression krtb gene markedly increased compared control group genes verified qrt pcr study provided new bioinformatics evidences induced myocardial tissue toxicity necessary cardiovascular system toxicity studies
combined fast fourier transform fft mathematical hybrid method accurately computing lightning current flowing along grounding grid buried multilayered earth model developed paper hybrid method electrical circuits consist typical elementary element accelerate calculation dynamic state quasi static complex image methods closed form green function introduced model model used study performance transient lightning response grounding grid
background parasacral transcutaneous electrical nerve stimulation tens effective method treatment overactive bladder oab additionally accelerates bowel transit time therefore parasacral transcutaneous electrical nerve stimulation tens improve lower urinary tract symptoms luts also resolves problem constipation significant number children since tens positive effect luts symptoms fecal retention possible action regarding oab could directly associated improvement constipation words positive effect parasacral tens oab would constipation resolved objective study test hypothesis objective test hypothesis positive effect parasacral tens oab would constipation improved method study design prospective study children oab alone submitted parasacral tens inclusion criteria consisted children idiopathic oab alone rome iii criteria children years age used diagnose constipation children treated sessions parasacral tens applied min three times weekly alternating days figure instructions given participants respect diet laxatives pharmaceutical treatment constipation throughout study period none patients used anticholinergics standard urotherapy prescribed results parasacral tens improves oab constipation presence constipation treatment associated poorer prognosis insofar resolution symptoms oab concerned likewise association resolution constipation parasacral tens resolution oab conclusion statistically significant difference urinary symptoms constipated nonconstipated children improvement urgency urge incontinency holding maneuvers constipated non constipated children however significant improvement enuresis resolution oab associated resolution constipation vice versa
paper explores potential possibilities applying critical design approach critical design thinking industrial company mapei mainly focusing improving product development creating innovative concrete surfaces construction industry urban spaces paper also discusses methodological challenges possibilities working cross disciplinary team consisting product designers tertiary level product design students chemical engineers relevant stakeholders study presents overview critical design approach continuation previous work methods design fiction poetic estrangement add value explore possibilities critical design interventions industrial material educational systems research consists series case studies participatory design workshops involved testing critical design approach tertiary level product design students participatory design workshops focused creating design fiction collection conceptual design proposals shift focus design object ideas concepts challenging stakeholders established ideas materials results conducted research participatory design workshops represent expansion critical design approach industrial educational contexts well public realm
consumption bread demands concerning quality features one appearance experiencing rapid growth thus standardization production aiming keep quality applying new methods objective research develop method optimize bread making processes based acceptability crust color effect bread experimentally produced using box behnlcen experimental design three factors sugar flour relation baking temperature baking time three answer variables parameters cielab color space determination color means acquisition pre processing analysis images bread samples getting color expressed cielab coordinates analysis sensorial acceptance made determining highest acceptance consumers finally optimization production process made based parameters getting optimal production parameters results show using proposed method possible correlate parameters cielab color space acceptance final consumer aiming optimize bread making processes means getting bread crust color maximum acceptability elsevier ltd rights reserved
study present high order numerical method based combined compact integrated rbf irbf approximation viscous flow fluid structure interaction fsi problems method fluid variables locally approximated using combined compact irbf incompressible navier stokes equations solved using velocity pressure formulation direct fully coupled approach fluid solver verified various problems including heat burgers convection diffusion equations taylor green vortex lid driven cavity flows applied simulate fsi problems elastic structure immersed viscous incompressible fluid fsi simulations employ immersed boundary framework using regular eulerian computational grid fluid mechanics together lagrangian representation immersed boundary immersed fibre membrane fsi problems although order accuracy present scheme generally similar fdm approaches reported literature present approach nonetheless accurate fdm approaches comparable grid spacings numerical results obtained present scheme highly accurate good agreement reported earlier studies problems elsevier ltd rights reserved
objectives examine influence evidence based guidance health care decisions study use seven different sources types evidence based guidance carried senior health professionals england responsibilities either directing purchasing health care based health authorities providing clinical care patients trust hospitals primary care design postal survey setting three health settings health authorities acute community trust hospitals primary care groups england sample subjects directors public health directors purchasing clinical directors consultants hospitals lead general practitioners main outcome measures knowledge selected evidence based guidance previous use ever beliefs quality usefulness perceived influence practice results usable response rate achieved respondents consulted least one source evidence based guidance ever past professionals health authorities much likely aware evidence based guidance consulted sources mean number different guidelines consulted either hospital consultants mean gps primary care mean little variation belief evidence based guidance good quality respondents health authorities significantly likely either hospital consultants gps perceive specified evidence based guidance influenced change practice across settings least used route accessing evidence based guidance internet several sources effect observed use ever health region health professional worked region guidance produced published evident national sources well initiatives produced locally predominantly local distribution networks conclusions evidence based guidance specified significantly likely seen contributed decisions public health specialists commissioners consultants hospitals gps primary care setting appropriate information support dissemination systems increase awareness access use evidence based guidance clinical interface developed
research social interaction nonverbal communication among individuals severe developmental disabilities also includes study body movements advances analytical technology give new possibilities measuring body movements accurately reliably one advance qualisys motion capture system qmcs utilizes optical markers capture body movements aim study explore practicality measuring body movements nonverbal communication child severe developmental disabilities preliminary case study undertaken social interaction boy developmental disabilities teacher analyzed using observer ratings psychological aspects social interaction measuring body positions velocity angles body movements using qmcs associations observer ratings measured body movements examined preliminary case study indicated emotional response attention level social interaction corresponded local synchronized movements face face orientation measurement motor behavior suggested potentially useful methodological approach studying social interaction communication development
background aims considering ability anti tnf alpha drugs lower burden intestinal inflammation patients inflammatory bowel disease ibd similarity ibd ankylosing spondylitis regarding inflammatory intestinal involvement aimed investigate impact anti tnf alpha biologic therapy subclinical intestinal inflammation patients methods january december patients controls enrolled study investigated small bowel videocapsule endoscopy examination ileocolonoscopy tertile small bowel proximal mid distal assessed calculating lewis score based image stream results lewis scores significantly higher group compared controls patients anti tnf alpha therapy adalimumab infliximab etanercept used nsaids simultaneously compared patients lewis scores lower compared patients entire small bowel proximal distal tertiles respectively lewis score also lower patients receiving adalimumab infliximab compared etanercept entire bowel distal tertile respectively conclusion anti tnf alpha therapy patients reduces subclinical intestinal inflammation magnitude seems depend upon class anti tnf alpha agent used clinical trials gov nct
since introduction biologics many concerns increased risk infections reported date real impact infections daily practice rheumatologic centers still largely unknown work evaluated infection rates associated use biologics large cohort patients prospective study january december enrolling rheumatic patients performed demographic disease characteristics therapies comorbidities infectious events recorded statistically analyzed multivariate analysis two hundred thirty five infectious episodes observed patients total infections bacteria identified total cases viruses common site serious infection urinary tract duration disease longer follow concomitant steroid therapy comorbidities significantly associated serious infection cohort episodes fulfilled criteria serious infection occurred different patients majority involving lower respiratory tract serious infections associated beginning biologics older age prospective observational study showed daily practice lesser rate serious well serious infections may observed rheumatic patients treated biologics reported previous papers common sites serious infections urinary respiratory tracts serious infections respiratory tract pathogens isolated find multidrug resistant organism
identification voltage current harmonic distortion voltage unbalance sources one main problems electric distribution systems order overcome paper use two novel indices proposed one hand load characterization index lci suggested calculate harmonic distortion introduced load index identifies linear non linear loads power systems hand unbalance current ratio ucr suggested assign responsibility system unbalance load source sides indices calculated measurement current input load voltage point common connection pcc main objective paper test performance two indices experimental three phase electrical network order several experimental tests considered elsevier rights reserved
gestures help people think help problem solvers generate new ideas conducted two experiments exploring self oriented function gesture novel domain creative thinking experiment explored relationship children spontaneous gesture production ability generate novel uses everyday items alternative uses task significant correlation children creative fluency gesture production majority children gestures depicted action target object restricting children gesturing significantly reduce fluency however experiment encouraged children gesture significantly boosted generation creative ideas findings demonstrate gestures serve important self oriented function assist creative thinking
french prison inmates reported satisfied sleep life habits good bad sleepers significantly different except television smoking frequently reported symptom insomnia several awakenings night frequently cited etiologies rumination thoughts noise patients reported sleeping problems began worsened incarceration quarter inmates following hypnotic treatment treatments began prison patients satisfied effectiveness observations enabled make recommendations healthy sleep patterns respecting normal night day cycles encouraging stop smoking promoting appropriate use hypnotic treatments
background fractures frequent reason emergency department visits evaluation abusive head trauma associated concern infants recent guidelines suggested retinal examination may necessary absence intracranial injury lack empirical evidence infants year age objective aim evaluate prevalence retinal hemorrhages infants isolated long bone fractures methods retrospective chart review infants year age presented urban tertiary care pediatric hospital january april diagnosis acute long bone fracture retinal hemorrhages patients excluded head injury altered mental status injury mechanism motor vehicle accident multiple fractures injuries outside fracture area patients identified trauma registry data international classification diseases codes results one hundred forty six patients isolated long bone fractures patients undergo retinal examination patients dilated eye examinations patients identified retinal hemorrhages patients identified retinal hemorrhages concerning abuse patients retinal hemorrhages isolated long bone fractures conclusions infants year age presenting isolated long bone fractures dilated eye examination evaluate retinal hemorrhages likely yield additional information results support recent studies subset children infants may require dilated eye examinations evaluation possible abuse elsevier inc rights reserved
windows azure storage cloud storage system provides customers ability store seemingly limitless amounts data duration time customers access data anywhere time pay use store data stored durably using local geographic replication facilitate disaster recovery currently storage comes form blobs files tables structured storage queues message delivery paper describe architecture global namespace data model well resource provisioning load balancing replication systems
paper presents phenomenographic analysis perceptions individuals asperger syndrome republic armenia primary objective apply develop existing theory unique national context across broader respondent group previous studies research compares contrasts views expressed individuals special educational needs disabilities sen parents individuals sen lay members public social comparison models developed hedley young huws jones locke utilised lenses analyse conceptions attitudes beliefs respondent group particular social cultural political history armenia offers insight challenges opportunities autism research former soviet union
high dimensional quantum key distribution qkd generate secure bits one detection event achieve long distance key distribution high secret key capacity letter present decoy state qkd scheme entangled single photon added coherent state espacs source present two tight formulas estimate single photon fraction postselected events eve holevo information derive lower bounds secret key capacity secret key rate protocol also present finite key analysis protocol using chernoff bound numerical results show protocol using one decoy state perform better previous qkd protocol spontaneous parametric conversion spdc using two decoy states moreover considering finite resources advantage obvious elsevier rights reserved
background progressive supranuclear palsy psp frontal presentation characterized cognitive deficits behavioral changes recognized early clinical picture distinct classical called richardson parkinsonism presentations midcingulate cortex associated executive attention tasks consistently found impaired imaging studies patients psp aim present study determine alterations neurotransmission underlying pathophysiology psp well significance clinically identifiable psp subgroups methods vitro receptor autoradiography used quantify densities different receptors caudate nucleus midcingulate area patients psp age sex matched control subjects results densities aminobutyric acid type peripheral benzodiazepine serotonin receptor type nmethyl aspartate receptors significantly higher area patients psp tau impairment stronger caudate nucleus kainate nicotinic cholinergic receptor densities significantly lower adenosine receptor type receptors significantly higher caudate nucleus patients psp receptor fingerprints also segregated psp subgroups clinical parameters occurrence frontal presentation tau pathology severity taken consideration conclusions demonstrate first time knowledge kainate receptors altered psp clinically identifiable psp subgroups differ neurochemical level numerous receptors altered midcingulate cortex suggesting may prove key region psp finally add evidence nondopaminergic systems play role pathophysiology psp thus highlighting potential novel treatment strategies
importance electric aircraft highlighted many publications projects industrial presentations definition electric aircraft concept achieves majority required system functionality using electrically powered sub systems components manifests much higher electrical power demands board aircraft compared conventional architectures presents many challenges design process alleviate risk choose optimum architectures systems aircraft essential incorporate characteristics possible configurations electrical network conceptual preliminary design stages hence current practice performing electrical load analysis detailed design stage adequate address gap paper presents viable robust methodology define requirements size components systems calculates electric power requirements preliminary design stages methodology uses conventional aircraft systems components baseline uses mathematical techniques logical sequences component operation developed research size electrical load profiles conventional aircraft adapts result electric aircraft concept adding key components would account difference conventional system electric system methodology presented makes design process robust aids choice optimum design aircraft
software development companies employ train provide software developers platform improve skills unfortunately investments lost software developer resigns company physically available carry work activities major problem experienced namibian companies paper investigates knowledge transferred retained software developers namibian companies using case study approach five software developers purposively selected five software companies city windhoek namibia data collected using structured interviews findings revealed namibian companies formal knowledge management strategy place management involved practices experienced software developers willing participate process result job insecurities findings also revealed knowledge gaps created namibian companies experienced software developer resigns company consequently hampers process based findings study therefore proposes knowledge management framework kmf namibian companies incorporates needs software developer well needs company create effective namibian companies kmf namibian companies presented five experts field software engineering experts validated kmf namibian companies found useful within context namibian companies kmf namibian companies expected improve way processes carried namibian software companies providing realistic approach improving practices
novel method monitoring parameters absorbing coatings widely used stealth technology described paper offered method measurements based use slow wave structures swss electrodynamic parameters strongly depend electromagnetic properties absorbing coatings main advantages sws based measurements possibility concentrate electromagnetic field volume linear dimensions much smaller wavelength free space split electric magnetic fields providing practically independent monitoring dielectric magnetic properties coatings resonant frequencies factor sws section placed parallel monitored coating used primary measuring parameters analysis dispersion equation derived sws based sensitive element presence coating allows creating algorithms converting measured electrodynamic parameters reading coatings electromagnetic properties shown also use coupled swss leads increase informative parameters number significant increase sensitivity
new generation computer games taken last years called massive multiplayer online role playing games mmorpg parallel usage games education increased exploiting fact young people familiarized would motivated learn entertained however mmorpg require significant amounts resources bandwidth ram cpu capacity support learning paper propose new methodology achieve monitoring optimization load balancing essential resources proper execution educational mmorpg computer programming foreseen bestowed without overloading system moreover present educational mmorpg called cmx aims teach computer programming interactive activities role playing finally apply proposed model cmx conducting experiment conclude server performance indeed increased
study proposes adaptive tuning algorithm dynamic adjustment saturation limits shoot duty ratio stdr modulation index source inverter adaptive tuning crucial source inverter applications wide fluctuations source voltage expected even though standalone application chosen demonstrate validity adaptive tuning algorithm proposed algorithm equally valid applications using source inverter based topologies also effects non idealities link voltage output voltages investigated stdr expressions link voltage maximal derived subsequently expressions utilised define saturation limit stdr proposed adaptive tuning algorithm transient phenomenon state switching behaviour source inverter closed loop operation analysed different perturbed conditions laboratory prototype single phase source inverter built demonstrate proposed adaptive tuning algorithm proposed algorithm associated control laws implemented using dspicf microcontroller effectiveness closed loop controlled single phase source inverter system tested linear non linear loads measured results close agreement analytical investigations
horizontal means reinforcement layers soil substrates installed roads rail routes also interaction geotextiles reinforcement soil subject discussion article effectiveness friction main factor efficiency immobilized planar reinforcement vertical uniform load utility mechanism occurrence friction forces adhesion reinforcement geotextile ground apparent balance forces appointed experimental testing well authors published elsevier ltd
several atypical antipsychotic drugs apds high affinity dopamine receptor relevance efficacy treatment cognitive impairment associated schizophrenia cias poorly understood aim study investigate effects receptor stimulation blockade novel object recognition normal rats sub chronic phencyclidine pcp induced novel object recognition deficit effect agonist antagonist studied alone combination clozapine lurasidone normal rats impaired novel object recognition whereas effect acutely reversed sub chronic phencyclidine induced novel object recognition deficit administration sub effective dose sed sub effective dose lurasidone also reversed deficit sub effective dose sub effective dose clozapine potent antagonist lurasidone reverse sub chronic phencyclidine induced novel object recognition deficit dose induce novel object recognition deficit blocked ability clozapine lurasidone reverse novel object recognition deficit receptor agonism beneficial effect novel object recognition sub chronic pcp treated rats augments cognitive enhancing efficacy atypical antipsychotic drug lacks affinity receptor lurasidone
background aging associated variations hypothalamic pituitary gonadal hpg axis hormones however clear aging changes hormones study examined natural alterations hpg axis aging men women china methods data obtained cross sectional study spect china areas three provinces east china february june subjects selected including men women aged years diseases affecting hpg hormones take exogenous supplements total testosterone estradiol free testosterone sex hormone binding globulin shbg follicle stimulat ing hormone fsh luteinizing hormone measured results men ranges percentiles hormone follows nmol shbg nmol pmol values higher men aged years aged years began increase progressively age years men reached eighties unadjusted annual age trend nmol year linear regression analysis full adjustment demographic variables metabolic factors hormones lifestyle morbidities showed higher levels still associated aging however ratio decreased age year shbg increased age pmol year nmol year respectively women percentile range pmol began decrease age years declined sharply age years pmol year stabilized low concentration age years percentile ranges fsh men women respectively fsh increased per annum men per annum women increased approximately per annum sexes conclusions influence aging hpg axis sex dependent pattern age related different chinese han men compared previous studies western populations values increased aging men suitable estimate life quality older chinese men based karger basel
recent years sustainability concept become common interest numerous disciplines reason popularity perform sustainable development concept green architecture also known sustainable architecture green building theory science style buildings designed constructed accordance environmentally friendly principles green architecture strives minimize number resources consumed building construction use operation well curtailing harm done environment emission pollution waste components design construct operate maintain buildings energy water new materials utilized well amounts waste causing negative effects health environment generated order limit effects design environmentally sound resource efficient buildings green building systems must introduced clarified understood practiced paper aims highlighting difficult complex issues sustainability encompass scope almost every aspect human life authors published elsevier ltd
background epidemiologic clinical evidence supports existence obesity related asthma phenotype distinct pathophysiologic elements specific biomarkers identified thus far increased oxidative stress reported objective aimed verifying whether metabolomics exhaled breath condensate obese asthmatic patients lean asthmatic patients obese nonasthmatic ona subjects could recognize specific statistically validated biomarkers separate asthma obesity respiratory metabolic phenotype defined metabotype methods twenty five patients ona subjects mild moderate age matched patients participated cross sectional study nuclear magnetic resonance nmr profiles analyzed using partial least squares discriminant analysis results validated independent patient set results nmr profiles obtained strong regression models distinguished patients ona subjects quality parameters goodness fit parameter goodness prediction parameter well patients patients allclasses comparison indicated patients possess respiratory metabolic profile fully divergent obtained patient groups also identified specific biomarkers class separation independent clinical bias involved methane pyruvate glyoxylate dicarboxylate metabolic pathways conclusions nmr based metabolomics indicates patients characterized respiratory metabolic fingerprint fully different patients independently affected asthma obesity phenotypic difference strongly suggests unique pathophysiologic pathways involved pathogenesis asthma adult obese subjects furthermore metabotype could define strategy patient stratification based unbiased biomarkers important diagnostic therapeutic implications
background clinical microbiological characteristics prosthetic joint infection pji caused candida species described including cases literature case candida glabrata infection handled present centre methods describe one patient using key words fungal prosthetic joint infection candida prosthetic joint infection searched medline national library medicine bethesda web science cinahl cochrane systematic review databases case reports condition results patients female mean age diagnosis yrs risk factors candidal infection systemic disease rheumatoid arthritis sjogren syndrome systemic lupus erythematosus immunosuppressive therapy cases diabetes mellitus immunosuppression due malignant chronic disease long term antibiotic use four patients infection site knee patients hip pain present patients swelling mean surgery diagnosis interval months frequent species albicans followed parapsilosis diagnosis obtained joint fluid aspirate cases intra operative samples susceptibility antifungals tested isolates frequently used antifungals fluconazole amphotericin two stage exchange arthroplasty performed patients resection arthroplasty patients cured combination medical surgical treatment one patient died infection conclusion pji caused candida requires high index suspicion surgery long term antifungal therapy recommended
background research aims understand role coping strategies self efficacy expectations predictors life satisfaction sample parents boys girls diagnosed autistic spectrum disorder methods total parents men women answered questionnaire life satisfaction coping strategies self efficacy scales results using regression model results show age child associated lower level satisfaction parents results show self efficacy variable best explains level satisfaction mothers use problem solving explains higher level satisfaction fathers men women show similar levels life satisfaction however significant differences found coping strategies women demonstrated higher expressing emotions social support strategies men conclusions development functional coping strategies high level self efficacy represents key tool adapting caring children autism results indicated necessity early intervention parents promote coping strategies self efficacy high level life satisfaction
geosynthetics umbrella term thin flexible material sheets applied civil environmental engineering geotextiles form largest group geotextiles consist polymer polyolefin polyester polyamide family additives improve stability polymer may degrade microplastic particles time various conditions cause adverse effects species may ingest particles encounter adverse effects due interference particles photosynthesis system case algae leaching additives may occur intact material often covalently bound polymer backbone greatly enhanced micro sized plastic particles formed total polymer additives identified ecotoxicity information available terms reach persistence toxicity bioaccumulation pbt assessment classified persistent toxic survey assess potential toxicity remaining substances revealed ecotoxicity studies performed compounds compounds toxicity data found well several chemical groups known used additives geotextiles current knowledge thus lacking two domains one hand ecotoxicity data scarce many substances yet subject ecotoxicological studies hand situ toxic effects might missed current approach single compound toxicity testing moreover environmental occurrence data additives extremely scarce elsevier right reserved
mammalian cerebrum exist two distinct types interneurons expressing nitric oxide synthase nos type neurons large size exhibit heavy nicotinamide adenine dinucleotide phosphate diaphorase nadph histochemical reaction type cells small light nadph reactivity time origin cortical neurons relative corticogenesis remains largely unclear among mammals explored issue guinea pigs using cell birth dating double labeling methods bromodeoxyuridine brdu pulse chasing doses apart given time pregnant mothers followed quantification nadph brdu colocalization parietal temporal neocortex offspring postnatal day type neurons partially colabeled brdu following pulsechasing embryonic day varied total population neurons three time groups type neurons partially colabeled brdu following pulse chasing total population individual time groups type neurons found express brdu total population individual time groups following pulse chasing results indicate guinea pigs type neurons generated early corticogenesis whereas type cells produced wide prenatal time window persisting birth data also suggest type nitrinergic neurons may undergo period development differentiation month nadph reactive
nonverbal behaviors exhibited patients depression interactions others may reflect social maladjustment depression maintenance investigations associations unipolar depression patients interviewers behaviors scarce restricted european samples study examined whether nonverbal behavior patients interviewers associated depression severity recovery cultural differences explored seventy eight depressed outpatients brazilians dutch evaluated week pharmacological treatment patients videotaped hamilton depression scale interview treatment brazilians also videotaped treatment nonverbal behaviors patients speaking effort interviewers encouragement analyzed using two factor ethogram results revealed speaking effort associated encouragement influenced baseline depression severity however treatment whereas encouragement remained unchanged speaking effort increased among unrecovered patients speaking effort associated patients culture brazilians exhibited higher speaking effort dutch findings highlight whereas supportive nonverbal behavior interviewer may stable set nonverbal behaviors composed head movements eye contact gestures displayed patients speaking clinical interviews reflects depression persistence treatment
paper novel set indicators presented arc faults detection electrical circuits indicators defined starting experimental characterization arc fault phenomenon study arcing current several test conditions chosen accordance standard requirements proposed parameters measured means high resolution low frequency spectral analysis arcing current allows achieve good spectral resolution even short observation windows
hierarchical grids appear various applications computer graphics subdivision multiresolution surfaces terrain models since different grid types perform better different tasks desired switch regular grids take advantages grids based domain obtained connectivity information mesh define simple conversions switch regular grids paper introduce general framework used convert given grid another discuss properties refinements transformations framework hierarchical meaning provides conversions meshes different level refinement describe use framework define new regular near regular refinements good properties small factors also describe grid conversion enables use patch based data structures hexagonal cells near regular refinements meshes converted set quadrilateral patches stored simple structures near regular refinements also supported defining two sets neighborhood vectors connect vertex neighbors useful address connectivity queries elsevier ltd rights reserved
geotextile tubes widely used reef structures crest mean sea level requirement beach width main criterion decide crest level nearshore reef structure greater depth placement stacked tubes may one alternative solutions certain circumstances geotextile tubes also used right eroding coastline well known tubes placed abutting eroding coastline get damaged early age experienced devbag maharashtra candolim goa shankarpur coast west bengal however geotextile tubes placed eroding coast covered sand rubble protection enhance life structure case beach nourishment project unsegmented row tubes placed msl useful many purposes acts offshore reef helps attenuating wave energy directly attacking coastline traps sediments downrush also acts barrier hold nourished sand recurring periodic expenditure beach nourishment also decreases beach stabilization within years experiences geotextile tubes coastal protection works india described paper pros cons geotextile tubes placement crest level decision significance protection fabric rays etc discussed details case studies
consider design problem marx generator electrical network pulsed power generator show components design conveniently cast structured real eigenvalue assignment significantly lower dimension state size marx circuit present two possible approaches determine solutions first symbolic approach consists use grobner basis representations allows compute finitely many solutions second approach based convexification nonconvex optimization problem polynomial constraints also comment conjecture number stages problem finitely many solutions necessary assumption proposed methods converge regard proof conjecture interesting challenge general interest real algebraic geometry field elsevier ltd rights reserved
emergence addictive problems associated development information communication technologies icts challenge mental health modern societies reason spanish mental health strategy currently project includes problem emerging addictions young people mental health topics analysed main objective research develop three screening tools used health staff psychologists physicians better link early detection early intervention field technological addictions paper three kind technological addictions selected internet social networks mobile video games two groups participants selected technology users internet social network mobile video games without psychological problems due use technologies people sought counselling advice addictive problems technologies three screening tools technological addiction internet social network mobile video games developed tools consist two items tests highest positive predictive values ppv differentiate non problematic users technologies addictive problem internet mobile video games article shows three screening tools used health clinical staff case professional supposes patient addictive problem three technologies screening procedure implemented diagnostic addiction confirmed patient treated psychological treatment based evidence advices also proposed need specialized intervention addiction
introduction objective computer aided diagnosis cad systems based medical imaging could support physicians several fields recently also applied histopathology aim work discuss detail design testing cad system segmentation discrimination blood vessels versus tubules biopsies kidney tissue elaboration histological images materials methods materials consist kidney biopsy slides kbs periodic acid schiff pas staining regions interest roi identified expert total vessels tubules kbs preparation digital acquisition conducted expert technicians department emergency organ transplantation deto university bari aldo moro italy slice red green blue rgb format image resolution pixel starting kbs images several techniques tested roi segmentation classification particular formerly describe innovative preliminary step segment regions interest procedure extract significant features finally discuss supervised artificial neural networks anns architecture based error back propagation training algorithm training sets builts using vessels non vessels tubules roi samples whose dimensions correlated vessels detected results performance best ann architecture trained using training set vessels among available vessels dataset evaluated terms false positives fps false negatives fns initial reduced dataset reveals good performance robustness terms fps reduction conclusion tests determined supervised ann approach consistent reveals good performance training phase based vessels non vessels tubules samples moreover method could improved using larger dataset diagnosed expert nephropathologists
many studies aimed characterize pressurized transient hydraulics however remains difficult assess importance dynamic effects robust manner modeling complicated tension computational efficiency physical accuracy address challenges incompressible flows article presents adaptive modeling approach combines novel hybrid formulation termed hybrid global gradient algorithm hgga variable time step vts hgga combines generalized rigid water column global gradient algorithms adapt inertially dominated flows without effects computational efficiency physical accuracy balanced adjusting formulation according simulated hydraulics three physically based indicators introduced characterize unsteady flow actively inform hgga model system two pipe networks used demonstrate current work first illustrates utility inertial indicators second comprises extended period simulation vts scheme although computationally intensive conventional modeling methodology shown provide better representation dynamic hydraulics
background prevalence allergic inflammatory diseases atopic dermatitis asthma allergic rhinitis worldwide increased complete recovery difficult korean red ginseng heat processed root panax ginseng meyer widely frequently used traditional medicine east asia study investigated whether korean red ginseng water extract rge regulates expression proinflammatory cytokines chemokines via mitogen activated protein kinases mapks nuclear factor kappa kappa pathway allergic inflammation methods compound induced anaphylactic shock fluoro dinitrobenzene dnfb induced like skin lesion mice models used investigate antiallergic effects rge human keratinocytes hacat cells human mast cells hmc also used clarify effects rge expression proinflammatory cytokines chemokines results anaphylactic shock dnfb induced like skin lesions attenuated rge administration reduction serum immunoglobulin ige interleukin levels mouse models rge also reduced production proinflammatory cytokines including beta expression chemokines thymus activation regulated chemokine tarc macrophage derived chemokine mdc hacat cells additionally rge decreased release tumor necrosis factor alpha tnf alpha beta well expressions chemokines including macrophage inflammatory protein mip alpha mip beta regulated activation normal cell expressed secreted rantes monocyte chemoattractant protein mcp hmc cells furthermore data demonstrated inhibitory effects occurred blockage mapk kappa pathway conclusion rge may useful therapeutic agent treatment allergic inflammatory diseases like dermatitis korean society ginseng published elsevier korea llc
myeloproliferative neoplasms mpn chronic phase evolve blast phase hold dismal prognosis represent urgent unmet clinical need mutational landscape mpn distinct novo acute myeloid leukemia offers insight molecular mechanisms contributing clonal evolution providing potential novel drug targets number retrospective studies identified patient disease specific variables associated increased risk leukemic transformation underlying mpn several prognostic models developed identify mpn patients highest risk may warrant early aggressive therapeutic intervention acute myeloid leukemia type induction chemotherapy offer significant survival benefit mpn unless followed hematopoietic stem cell transplantation unfortunately patients mpn candidates hematopoietic stem cell transplantation result advanced age competing comorbid conditions lack acceptable donor graft option jak inhibitor monotherapy effective reducing splenomegaly symptom burden majority treated patients myelofibrosis still occur high dose jak inhibitor monotherapy appears tolerable modestly active treatment mpn current jak inhibitor based combination therapy approaches supported preclinical investigation currently tested multi center clinical trials elsevier inc rights reserved
paper describes optimization piston bowl geometry operating conditions dual fuel engine based compression ignition engine using gasoline port fuel injection diesel direct injection kiva code coupled chemkin chemistry solver used simulation micro genetic algorithm used optimization algorithm micro genetic algorithm smaller population conventional genetic algorithm optimization proposed algorithm six populations generation sixteen variables composed seven geometry variables nine operating condition variables result optimization improvement gross indicated specific fuel consumption simultaneous decrease overall nox soot emissions achieved also amounts carbon monoxide unburned hydrocarbons decreased baseline case entrant shape optimized case shallow shape narrower spray angle furthermore operating conditions gasoline total fuel ratio increased similar gasoline hcci homogenous charge compression ignition engine egr exhaust gas recirculation rate increased dilution boost pressure initial temperature decreased elsevier ltd rights reserved
recent literature seasonal affective disorder sad begun focus diathesis stress models including young colleagues dual vulnerability hypothesis dual vulnerability hypothesis posits individuals must possess biological vulnerability developing vegetative symptoms psychological vulnerability developing mood symptoms order develop sad episodes however studies directly tested model recently research demonstrated temporal relation mood vegetative symptoms vegetative symptoms earlier onset mood symptoms supporting idea separate factors related two symptom clusters exist current study represents longitudinal assessment vegetative mood symptoms well cognitive factors rumination automatic thoughts may represent part psychological vulnerability shared sad sufferers furthermore present study represents second assess state levels cognitive factors may impact recurrent sad episode severity fifty one individuals participated study across two groups individuals history sad history depression sads findings supported dual vulnerability hypothesis early vegetative symptom onset mood symptom evident individuals history sad participants history sad also reported ruminative responses negative automatic thoughts seasons findings generally supportive young colleagues dual vulnerability hypothesis directions future research suggested
circadian rhythm biological rhythm governing physiology behavior period approximate molecular level circadian output controlled molecular clock composed positive negative feedback loops transcriptional post translational processes clock transcription factor known central component molecular clock feedback loops generating circadian oscillation although clock known undergo multiple post translational modifications knowledge entities remains limited cyclin dependent kinase cdk proline directed serine threonine kinase involved various neuronal processes report cdk novel regulator clock protein cdk phosphorylates clock thr thr residues association transcriptional activation clock cdk dependent regulation clock function mediated alterations stability subcellular distribution results suggest cdk novel regulatory component core molecular clock machinery
shyness linked several distinct behavioral antecedents biological correlates across development including early behavioral inhibition neuroendocrine dysregulation present study examined whether self reported history childhood behavioral inhibition concurrent cortisol output sex affected shyness levels adults results revealed history childhood social behavioral inhibition predicted higher shyness among female adults high levels cortisol output among women low cortisol levels relation childhood social behavioral inhibition shyness levels associations consistent examining history nonsocial behavioral inhibition among adult males findings highlight importance differentiating social versus nonsocial behavioral inhibition examining relations childhood temperament adult shyness findings raise possibility neuroendocrine dysregulation may unique role predicting maintaining social behaviors shyness depending sex individual differences temperament elsevier ltd rights reserved
analgesic effects ibuprofen immediate release extended release tablets evaluated randomized double blind placebo controlled dental pain studies patients years old moderate severe pain following third molar extraction received single dose ibuprofen formulation naproxen sodium placebo study doses ibuprofen formulation placebo study study mean standard deviation time weighted sum pain intensity difference scores placebo ibuprofen ibuprofen naproxen respectively hours hours placebo study mean time weighted sum pain relief pain intensity difference scores versus hours versus hours placebo versus ibuprofen respectively efficacy sustained four hour dosing intervals ibuprofen gastrointestinal adverse events predominated placebo study medication administration rescue medication use applicable ibuprofen provided safe effective analgesia single multiple doses
paper deals influence piping material thermal geometrical properties dynamic stability single phase natural circulation loops purpose semi analytical approach developed adopting tools provided linear analysis considering generic natural circulation loop configuration localized heat flux homogenously distributed internal heat generation ihg governing equations mass momentum energy balance linearized around steady state solution system treated means fourier transform obtain dimensionless stability maps moreover order verify linear analysis methodology numerical strategy adopted solve nonlinear governing equations investigate natural circulation dynamics time domain principle developed approaches applied natural circulation loop configuration present work linear nonlinear analyses applied specific natural circulation loop geometry namely horizontal heater horizontal cooler hhhc one regard object oriented one dimensional model hhhc loop developed assessment model obtained results compared relap computational fluid dynamics cfd time dependent simulations elsevier ltd rights reserved
input offset voltage quit important performance parameter operational amplifiers low frequency noise great effect offset voltage paper chopping technology efficient approach decrease noise offset voltage cmos amplifiers adopted low pass filter multiplier composed used filter modulation noise circuit presented chopper amplifier designed simulated cmos process supply simulated results show total harmonic distortion chopper amplifier chopper frequency khz input referred noise root khz average power consumption proposed technology pleasurable preference
present contribution significant extension work kelbin fluid mech vol new time dependent helical coordinate system introduced lie symmetry methods employed spatial dependence originally three independent variables reduced one remaining variables cylindrical radius time dependent helical variable alpha phi const time variables usual cylindrical coordinates alpha arbitrary function time assuming alpha const retain classical helically symmetric case using imposing helical invariance onto equation motion leads helically symmetric system euler navier stokes equations time dependent pitch alpha may varied arbitrarily explicitly contained latter equations conducted primitive variables well vorticity formulation hence significantly extended set helically invariant flows may considered may altered external time dependent strain along axis helix finally sought new conservation laws found helically invariant euler navier stokes equations derived herein new conservation laws considerable extensions existing conservation laws helical flows constant pitch interestingly enough certain classical conservation laws admit extensions new time dependent coordinate system
investigate controllable behavior nonautonomous soliton external potentials variable dispersion nonlinearity management functions describes propagation optical pulses inhomogeneous fiber system derive lax pair variable spectral parameter exact multi soliton solution generated via darboux transformation based solutions several novel optical solitons constructed selecting appropriate functions main evolution features waves shown interesting figures computer simulation examples breathers periodic potential soliton compression exponentially dispersion decreasing fiber interaction boomerang solitons discussed presented results applications study nonautonomous soliton birefringence managed switching architecture results potentially useful management nonautonomous soliton external potentials optical soliton communications long haul telecommunication networks
cardiovascular diseases cvds leading cause death western world current development clinical diagnostics accurately measure extent specifics cvds laudable goal better understanding structure function relation cardiovascular system much fundamental understanding comes development study models integrate biology medicine imaging biomechanics information models provides guidance developing diagnostics implementation diagnostics clinical setting turn provides data refining models review introduce multi scale multi physical models understanding disease development progression designing clinical interventions begin multi scale models cardiac electrophysiology mechanics diagnosis clinical decision support personalized precision medicine cardiology examples arrhythmia heart failure introduce computational models vasculature mechanics associated mechanical forces understanding vascular disease progression designing clinical interventions elucidating mechanisms underlie diverse vascular conditions conclude discussion barriers must overcome provide enhanced insights predictions decisions pre clinical clinical applications
athletic injuries hand wrist continue increase athletes get bigger faster weekend warrior continues active throughout lifespan management hand wrist injuries athletes depends sport position timing season injury occurs many years athlete left play competition past injuries thought trivial ideally managed complications occur may keep skilled athlete weekend warrior prolonged period time article concentrates common athletic injuries hand wrist
three basic diffusion properties argon shear viscosity bulk viscosity thermal conductivity studied neighborhood critical point using molecular dynamics lennard jones potential energy function simulations performed along isobars green kubo relations lennard jones pair potential used four different sets lennard jones parameters used comparison computed shear viscosity thermal conductivity values data available national institute standards technology nist displayed good agreement results bulk viscosity indicated values property neglected thermodynamic region result violates traditional much assumed stokes hypothesis classical fluid mechanics furthermore shown neighborhood critical region bulk viscosity larger values shear viscosity elsevier rights reserved
objective use conduit established surgical method reconstruction right ventricular outflow tract congenital heart disease however limited durability makes reintervention almost inevitable studied trends new implantation reoperation transcatheter pulmonary valve replacement tpvr swedish national perspective design results swedish registry congenital heart disease swedcon used collect data increase adult patients conduits surgical conduit replacements tpvrs new conduit implantations study period perioperative mortality yearly number new implantations reoperations doubled study period patients new implantations older mean age years compared reoperation tpvr groups mean age years majority patients tetralogy fallot majority conduit reinterventions surgical also introduction tpvr significant difference regarding diagnosis gender age previous number longevity conduits conclusion number adults conduits increased steadily conduit related operations new implantations patients tetralogy fallot surgical conduit replacements increased significantly represented majority conduit reinterventions introduction tpvr indicating tpvr used majority patients conduit failure diagnosis gender age previous number longevity conduits impact choosing surgical replacement tpvr
paper concerned approximations boltzmann equation based method moments propose generalization setting moment closure problem relative entropy divergences corresponding closure procedure based minimization divergences proposed description encapsulates special cases grad classical closure based expansion hermite polynomials levermore entropy based closure establish generalization divergence based closures enables construction extended thermodynamic theories avoid essential limitations standard moment closure formulations inadmissibility approximate phase space distribution potential loss hyperbolicity singularity flux functions local equilibrium divergence based closure leads hierarchy tractable symmetric hyperbolic systems retain fundamental structural properties boltzmann equation
objective study aimed investigate feasibility intervention program women breast cancer undergoing adjuvant anticancer therapy determine preliminary effectiveness reducing unmet needs psychological distress methods intervention based collaborative care model compromised four domains identification unmet needs problem solving therapy behavioral activation supervised psychiatrist psychoeducation referral relevant departments eligible women breast cancer provided collaborative care intervention four sessions feasibility program evaluated percentage women entered intervention percentage adherence program self reported outcomes measured supportive care needs survey short form scns profile mood states poms european organization research treatment cancer quality life questionnaire eortc qlq concern recurrence scale pre post intervention satisfaction medical care results total patients participated study rate participation intervention rate adherence participants significantly improved scores total perceived needs physical needs psychological needs scns vigor confusion poms function physical emotional cognitive nausea vomiting dyspnea appetite loss financial difficulties eortc qlq compared baseline assessment conclusions findings indicated intervention program feasible study needed demonstrate program effectiveness reducing unmet needs
patients ischemic cardiomyopathy icm prone scar related ventricular tachycardia success ablation depends accurate arrhythmogenic substrate localization followed optimal delivery energy provided constant electrode tissue contact current manual remote magnetic navigation rmn guided ablation strategies aim identify reentry circuit target critical isthmus activation entrainment mapping ongoing tachycardia magnetic trial assess ablation using niobe magnetic navigation system results superior outcomes compared manual approach subjects ischemic scar low ejection fraction randomized single blind prospective multicenter post market study total subjects per group enrolled randomized treatment niobe system treatment via manual procedure sites study population consist patients ischemic cardiomyopathy left ventricular ejection fraction lvef implantable cardioverter defibrillator icd sustained monomorphic primary study endpoint freedom recurrence months secondary endpoints acute success freedom year large scar subpopulation procedure related major adverse events mortality rate month follow follow consist visits months include icd interrogation magnetic trial help determine whether substrate based ablation rmn clinical advantages manual catheter manipulation
paper reports model assisted bundle adjustment framework visually derived features fused underlying three dimensional mesh provided priori using approach inspired expectation maximization class algorithms introduce hidden binary label visual feature indicates feature considered part nominal model feature corresponds structure absent model therefore addition improved estimates feature locations identify visual features correspond foreign structure ship hull show framework special case gaussian max mixtures framework efficiently incorporated state art graph based simultaneous localization mapping slam solvers addition precision bundle adjustment framework allows identification structural deviations structure inferred bundle adjusted camera imagery prior model structural deviations clustered shapes allow fuse camera derived structure back mesh augmented model used within photomosaicing pipeline providing visually intuitive reconstruction ship hull evaluate pipeline using bluefin robotics hovering autonomous underwater vehicle hauv surveying curtiss mesh derived computer aided design cad drawings serves prior model addition consistent visual reconstructions update prior mesh information corresponding underwater structure biofouling manually placed cylindrical shapes known dimensions elsevier rights reserved
studies suggested compromised postural control individuals knee osteoarthritis evidenced larger faster displacement center pressure cop however quantification postural control mini squat posture performed patients early knee relation muscle strength self reported symptoms investigated main aim cross sectional observational controlled study determine whether postural control mini squat posture differs individuals early knee control group verify relation among knee extensor torque met self reported physical function stiffness pain twenty four individuals knee grades oag mean age twenty subjects without knee injuries mean age participated study participants assessed postural control force plate bertec mod usa provided information anterior posterior medial lateral cop displacement mini squat isometric concentric eccentric knee extensor torque met isokinetic dynamometer biodexmulti joint system biodex medical incorporation new york usa self reported symptoms womac questionnaire main outcomes measured cop amplitude velocity displacement isometric concentric eccentric ket self reported physical function stiffness pain significant differences found groups postural control significant lower eccentric met higher scores womac subscales pain stiffness physical function found oag moderate negative correlations found cop amplitude displacement physical function rho moderate negative correlations observed cop velocity displacement physical function rho stiffness rho findings present study emphasize importance rehabilitation early degrees knee prevent postural instability need include quadriceps muscle strengthening especially eccentric contractions relationship self reported symptoms lower slower cop displacement suggest postural control strategy tasks semi flexed knee investigated elsevier rights reserved
asymptotic property maximum likelihood estimator mle utilized reconstruct threedimensional sectional images photon counting imaging pci regime first multiple intensity images known elemental images captured geometric ray tracing method employed reconstruct sectional images various depth cues note sectional image consists focused defocused regions depending reconstructed depth position defocused portion redundant removed order facilitate image analysis object tracking recognition classification navigation paper present subpixel level three step based technique involving adaptive thresholding boundary detection entropy based segmentation discard defocused sparsesamples reconstructed photon limited sectional images simulation results presented demonstrating feasibility efficiency proposed method
conduct disorder prior age precursor schizophrenia minority cases associated violent behavior adulthood taking account substance misuse present study used structural magnetic imaging examine gray matter volumes among men schizophrenia preceded szcd men schizophrenia without szcd men healthy men groups schizophrenia similar terms age onset duration illness levels psychotic symptoms medication groups similar number symptoms lifelong aggressive behavior number criminal convictions men szcd relative szcd displayed increased volumes hypothalamus left putamen right cuneus precuneus right inferior parietal cortex controlling age alcohol drug misuse decreased volumes inferior frontal region men szcd relative szcd group relative group displayed increased volumes hypothalamus inferior superior parietal lobes associated substance misuse aggressive behavior prior age lifetime tendency positively correlated volume hypothalamus thus among males szcd represents distinct subtype schizophrenia although differences behavior emerge childhood remain stable adulthood research needed determine whether differences volumes result abnormal neural development distinct males developing schizophrenia
background prevalence self reported gastrointestinal symptoms distress high studies quantified impact health related quality life hrqol methods conducted prospective cohort study patients hiv care ontario canada general linear mixed models used assess impact symptoms diarrhea soft stool nausea vomiting bloating painful abdomen loss appetite weight loss wasting distress range physical mental hrqol summary scores range measured medical outcomes survey results total participants completed one questionnaires median interquartile range iqr baseline men sex men white median age iqr median count iqr undetectable hiv viremia mean standard deviation mental physical hrqol scores respectively adjusted models compared reporting symptoms symptom distress scores symptom bothers little symptom bothers lot associated lower mental hrqol loss appetite distress scores scores diarrhea nausea vomiting bloating score weight loss independently associated lower physical hrqol scores increasing symptom distress associated impaired mental physical hrqol conclusions increasing symptom distress associated impaired mental physical hrqol identifying treating preventing symptoms may reduce overall symptom burden improve hrqol patients hiv
objectives motivation change behavior important therapeutic factor affects treatment outcomes patients substance use disorders motivation level influences treatment engagement retention outcomes assessment motivation important aspect management patients methods total patients admitted kasr ainy addiction unit fulfilling diagnostic statistical manual mental disorders edition criteria one substance dependence disorder included patients assessed using stage change readiness treatment eagerness scale socrates addiction severity index attending motivation incentives group psychotherapy sessions session week patients reassessed using socrates sessions results socrates increased scales motivationincentives groups however recognition ambivalence scales showed significant increase respectively whereas increase taking steps scale statistically significant best fit model regression calculated factors thatmaypredictsocrates group age patient education years main substance abuse either tramadol substances history suicide previous treatment trial positive negative medical history history alcohol use history legal problems presence family issues psychiatric complications predictors recognition ambivalence taking steps components motivation conclusions short motivation incentives group therapy may improve readiness change patients polysubstance dependence
stabilisation problem considered study nonlinear multiple time delay singularly perturbed ndsp systems first neural network model employed approximate reduced order model ndsp plant linear differential inclusion ldi state space representation established dynamics model based ldi state space representation robustness design fuzzy control proposed stabilise ndsp system designed fuzzy controller stabilise ndsp system dither auxiliary fuzzy controller simultaneously introduced stabilise ndsp system frequency dither high enough outputs dithered system corresponding mathematical model relaxed system made close desired makes possible obtain rigorous prediction stability dithered system establishing relaxed system finally study provides numerical example simulations illustrate concepts discussed throughout article
paper computer network information security network strategy reviewed article basis kinds network safety measures technology carry analysis banding mechanical electronic technical computer network example introduces computer network networking strategy computer network information safety protection strategy actual operation computer network hardware software internet use management rules regulations series protective measures set actual situation network security environment guarantee stable operation network education teaching provided support computer network construction computer information safety protection provide beneficial reference
east campaign new internal coil power supply used order enhance control plasma vertical instabilities power supply allows current voltage working modes much higher peak voltages currents faster response time comparison previous power supply allowed current mode bangbang pid composite controller designed voltage mode based optimal control theory rzip rigid plasma response model paper demonstrate faster enhanced controllability realized combination bangbang pid controller large position drift bangbang controller export maximum voltage achieve much faster power supply response slow vertical displacement events vdes pid controller used small drifts finally stabilize vdes minimum position oscillation furthermore evaluate time latency control system power supply stability performance closed loop simulated analysed controller finally implementation test east using quasi snowflake shape achieved growth rates paper shows new power supply using bangbang pid controller significantly enhance control vertical instabilities elsevier rights reserved
railroad track one geosynthetic applications geosynthetic used multiple functions namely reinforcement separation filtration drainage present study static cyclic tests performed full panel railway track models laid compacted soil subgrades tests performed model tracks two different thicknesses subballast layers laid two different subgrade soils namely dhanaury clay delhi silt model tracks adequately instrumented record induced stresses displacements track model tracks reinforced geogrid geotextile suitable interfaces track conditions heavy rainfall simulated model tracks reinforced geogrid ballast subballast interface effective reducing tie displacements ballast subballast strains subgrade displacements compared model tracks reinforced geotextile subballast subgrade interface dhanaury clay used subgrade soil conversely model tracks reinforced geotextile performed better respect reduced tie displacement subgrade displacement subballast strain compared model tracks reinforced geogrid delhi silt used subgrade soil elsevier ltd rights reserved
air pollution represented haze china attracted great global attention recent years china recently introduced series action plans improve air quality prevent air pollution remediation small coal fired boilers development heat power cogeneration hpc centralized heat supply chs important measures preventing air pollution paper introduces mentioned policies industrial park guangdong province china taken example analyze contributions hpc based industrial chs energy saving environmental protection benefits heat supplier user also analyzed furthermore paper presents difficulties challenges developing industrial chs including mismatching early phase price dispute measure dispute negative inter effects reasons problems analyzed possible solutions provided elsevier rights reserved
mechanism characteristic current oscillation four quadrant converter predictive current controller caused nonlinear characteristic system analyzed paper discrete model considering digital control delay single phase four quadrant converter stability condition derived using describing function saturation characteristic frequency amplitude nonlinear oscillation obtained simulation experiment results verify analyses
paper presents research results german namibian joint research project cuvewaters different technologies small scale rain floodwater harvesting introduced pilot plants central northern namibia part broader integrated water resources management iwrm approach central northern namibia semi arid climate conditions clearly distinctive dry wet seasons rain floodwater harvesting irrigation purposes intended increase resilience agricultural production building buffers interseasonal dry spells make irrigation farming possible dry season intended improve availability vegetables rural parts namibia derive income local markets besides raising temperatures climate change sub saharan africa predicted increase rainfall variability therefore adaptations also present precondition adapting future climate change within project different organisational approaches harvesting rainwater household well communal level tested well different locally available tank construction materials technologies developed cooperation local communities framed capacity development measures yielded good results enabled diffusion technology region based years research construction ferrocement tanks household level ponds covered shade nets communal level recommended due high evaporation rates gardens irrigated harvested rainwater equipped water saving drip irrigation systems combination capacity development focusing water management enabled users irrigate gardens throughout dry season
language important part culture allows exchange thoughts feelings well acquisition knowledge deficits language abilities appear different linguistic levels phonetics phonology lexicon semantics syntax morphology pragmatics concern language comprehension speech production different ways different linguistic levels considered diagnosis developmental language disorders particular german guidelines interdisziplinare leitlinie support approach paper gives overview symptoms specific language disorder well classification dsm icd moreover outlook toward icd explanations based beta draft similarities differences three diagnostic systems pointed discussed furthermore reference made interdisziplinare leitlinie distinction expressive receptive language disorders icd dsm two disorders summarized one clinical picture current icd beta draft disorders still divided however subordinate common category represents compromise two approaches additionally dsm supplemented diagnosis social pragmatic communication disorder likely disorder included icd developmental language disorder impairment mainly pragmatic language disorder characterized deficits verbal nonverbal communication future research consider pragmatic aspects language overview shows uniform diagnostic criteria furthermore none illustrated systems considered individual linguistic level language suggested interdisziplinare leitlinie although icf also capture linguistic levels enables comprehensive description impairments abilities differential diagnosis mental retardation must excluded nonverbal intelligence diagnosis controversial difficult implement logopedics practice speech therapy moreover diagnosis specific language disorders double discrepancy criterion must scrutinized current interdisziplinare leitlinie criterion waived controversy practice different definitions classifications specific language disorders lead significant variations data prevalence additionally causal research effectiveness tests therapeutic interventions complicated moreover long period uniform standard design assessments diagnosis reliable diagnosis language developmental disorders requires comprehensive interdisciplinary classification
background prostaglandin pge essential intrafollicular regulator ovulation contrast one gene one protein concept synthesis peptide signaling molecules production metabolism bioactive pge requires controlled expression many proteins correct subcellular localization enzymes coordinated pge synthesis metabolism prostaglandin transport cells facilitate pge action degradation elevated intrafollicular pge required successful ovulation disruption pge synthesis metabolism transport may yield effective contraceptive strategies methods review summarizes case reports studies ovulation inhibition women macaques treated cyclooxygenase inhibitors published findings discussed context studies describing levels mrna protein activity prostaglandin synthesis metabolic enzymes well prostaglandin transporters ovarian cells results ovulatory surge regulates expression component pge synthesis metabolism transport pathway within ovulatory follicle data primary ovarian cells cancer cell lines suggest enzymes transporters cooperate optimize bioactive pge levels elevated intrafollicular pge mediates key ovulatory events including cumulus expansion follicle rupture oocyte release inhibitors prostaglandin endoperoxide synthase ptgs enzyme also known cyclooxygenase cox reduce ovulation rates women studies macaques show ptgs inhibitors reduce rates cumulus expansion oocyte release follicle rupture oocyte nuclear maturation fertilization ptgs inhibitor reduced pregnancy rates breeding macaques administered simulate emergency contraception however ptgs inhibition prevent pregnancy monkeys administered simulate monthly contraceptive use conclusion ptgs inhibitors alone may suitable use emergency contraceptives however drugs class unlikely effective monthly contraceptives inhibitors additional pge synthesis enzymes modulation pge metabolism transport also hold potential reducing follicular pge preventing ovulation approaches target multiple components pge synthesis metabolism transport pathway may required effectively block ovulation lead development novel contraceptive options women therapies target pge may also impact disorders uterus could also benefits women health addition contraception
prospective observational study performed hospitalized patients proven suspected invasive fungal infection treated mean days micafungin mcf preexisting liver function impairment plasma levels mcf steady state correlated liver function tests beginning treatment liver function remained stable even improved patients except one mcf discontinued due liver toxicity elsevier espana sociedad espanola enfermedades infecciosas microbiologia clinica rights reserved
microinsurance recently received much attention promising tool protect poor individuals important shocks yet voluntary demand people low shedding doubt viability microinsurance useful risk management tool better understand puzzle paper reviews theoretical empirical literature demand insurance people lack understanding insurance seem limit demand several fundamental factors price quality limited trust insurer liquidity constraints also seem important role explaining puzzle elsevier ltd rights reserved
due significant drop energy needed desalination kwh kwh past years close theoretical minimum recovering salt free water seawater kwh focus critical aspects offer opportunities reduce costs include pre post treatment analysis optimization performance systems selectivity capacity flux decline flux decline includes concentration polarization fouling inorganic organic biological constituents call three legs undergird membrane processes approach quantitative includes detailed fluid mechanics associated mass transfer systems optimizing performance published elsevier
ternary quaternary metal oxides form rapidly emerging class new functional materials tackling grand challenge efficient solar energy harvesting currently main interest devoted characteristics materials little consideration given preparation solution combustion synthesis scs considered green sustainable alternative widely employed energy time consuming synthesis methods study scs employed prepare bitio perform bandgap engineering foreign ion incorporation synthesized materials characterized powder ray diffraction transmission electron microscopy energy dispersive ray microanalysis diffuse reflectance vis raman spectroscopy surface area determination via adsorption found nanocrystalline materials formed scs synthesis phase composition materials amount foreign metal ions incorporated parent structure could effectively controlled consequently scs technique provided simple reliable tool bandgap engineering photocatalytic activity materials tested methyl orange degradation intrinsic photocatalytic activity various samples compared deconvoluting effect vastly different specific surface areas elsevier rights reserved
influence constant speed wind turbine electrical network torque impact lead various problems disturbances affect active power quality reactive power phase phase voltage paper propose original system control solve firstly problems due variation voltage source secondly brutal impact active reactive powers principle proposed wind energy system statcom supercapacitor energy storage limit rapid variation active power give required reactive power compensation induction machine torque change supercapacitor directly coupled common link whole bidirectional converter control strategy statcom uses linear matrix inequalities lmis approach regulate currents injected absorbed inverter strategy used control variable supercapacitor voltage simulation results statcom using state feedback integral controller currents converter simple proportional controller cascaded axis current loop voltage source presented discussed finally implementation real time performed first experimental results presented validate proposed control elsevier ltd rights reserved
ankylosing spondylitis spinal arthritic disease often associated human leukocyte antigen hla part hla carriers become patients cells reported play important role pathology cell immunoglobulin mucin domain containing molecule tim programmed death known negatively regulate immune response study used flow cytometry analyze immunological differences peripheral blood patients cases found hla positive hla group normal healthy individuals healthy group level cells treg group observed expression tim production ifn gamma tnf alpha examined well found percentage treg group lower healthy group expression cells tim cells lower group group lower production cells higher production cells results hla group similar healthy group data suggested patients impairment ability negatively regulate immune response might related etiology investigate roles tim cells cells tested ifn gamma production tim tim cells patients found tim tim cells produced subsets conclusion dysfunction cells associated tim
context large engineering projects effective efficient exchange versioning information different engineering disciplines essential semantic data integration approaches provide necessary means overcome gap heterogeneous local engineering tool concepts common project level concepts enable mapping engineering data coming different disciplines however evaluations shown ontology based stores satisfy versioning query performance criteria case large multi disciplinary engineering projects paper present architecture solution uses ontologies describe engineering models nosql graph database version individuals evaluate software architectures according quality attributes performance scalability context industrial scenarios compare related approaches main results suggest architecture outperforms ontology stores match solutions relying relational databases
syndrome characterized trisomy chromosome frequently associated thyroid dysfunctions due underlying autoimmune disorders hypothyroidism commonest thyroid dysfunction hyperthyroidism usually graves disease far less common literature review came across approximately cases reported far first case report published data india hyperthyroidism syndrome three case reports report one patient adult male years administered iodine definitive treatment years initial diagnosis
background large amount financial incentive effective increase tobacco abstinence effect small amount unknown purpose evaluated small amount cash incentive increased abstinence quit attempt use cessation aids methods three armed block randomized controlled trial recruited adult daily smokers participated hong kong quit win contest biochemically validated quitters early informed notified incentive week month follow late informed incentive group notified month follow received incentive months validated quitters control group received incentive months without prior notification subjects received brief advice self help education card page booklet outcomes self reported day point prevalence abstinence quit attempt intentional abstinence least use cessation aids month follow results intention treat early informed group month follow reported higher rate quit attempt smoking least groups odds ratio similar abstinence early late informed group showed similar quitting outcomes early informed group reported quit attempts reading self help materials groups conclusions small cash incentive early notification increased quit attempt self directed help abstinence future financial incentive based programmes larger incentive accessible quitting resources encouragement using existing smoking cessation services needed elsevier ltd rights reserved
bacterial septic arthritis rarely occurs upper extremities yet early diagnosis treatment important delay diagnosis results pain impaired hand function degenerative joint disease radioscapholunate rsl arthrodesis well established procedure treating inflammatory arthritis osteoarthritis primary posttraumatic primarily achieve pain relief wrist deformity correction offers alternative option total wrist arthrodesis indications rsl arthrodesis osteoarthritis radiolunate radioscaphoid joint concomitant intact midcarpal joint present case study spontaneous rsl fusion post wrist infection caused dog bite
work context reconstructs feminine masculine rendering public service mirror gender asymmetry nowhere clearer local government many face face services delivered cities counties largest job categories education police work almost elementary school teachers women less police officers women sequelae job segregationoverlooking emotive component jobs pay inequity glass wallswill change organizational logic catches nuanced appreciation gender
psychopathy personality disorder characterized lack affection remorse empathy ability seduce manipulate use people goal perform bibliometric review articles published scientific journals listed psycinfo database february using keywords psychopathy antisocial personality disorder results provide information evolution treatment terms annual productivity place publication recurrent scientific journals prolific authors popular keywords well efforts undertaken prison samples content analysis main authors show need increase diagnostic criteria psychopathy according gender social context personality traits
psoriasis common chronic inflammatory disease skin increasingly recognized systemic inflammatory disorder psoriatic arthritis well known comorbidity psoriasis rapidly expanding body literature various populations settings supports additional associations psoriasis cardiometabolic diseases gastrointestinal diseases kidney disease malignancy infection mood disorders pathogenesis comorbid disease patients psoriasis remains unknown however shared inflammatory pathways cellularmediators genetic susceptibility common risk factors hypothesized contributing elements additional psoriasis comorbidities continue emerge education health care providers essential ensuring comprehensive medical care patients psoriasis
purpose study determine whether intravoxel incoherent motion ivim derived parameters apparent diffusion coefficient adc could act imaging biomarkers predicting antifungal treatment response forty six consecutive patients mean age newly diagnosed invasive fungal infection ifi lung according eortc msg criteria prospectively enrolled patients underwent diffusion weighted magnetic resonance imaging using values sec adc pseudodiffusion coffiecient perfusion fraction diffusion coefficient compared patients favourable unfavourable response values significantly lower unfavourable response group favourable response group receiver operating characteristic curve analyses showed significant predictor differentiation sensitivity specificity ivim mri potentially useful prediction antifungal treatment response patients ifi lung results indicate low perfusion fraction may noninvasive imaging biomarker unfavourable response aeuro cent recognition ifi indicating clinical outcome important treatment decision making aeuro cent ivim reflect diffusion perfusion information ifi lesions separately aeuro cent perfusion characteristics ifi lesions could help differentiate treatment response aeuro cent initial low may predict unfavourable response ifi
disposal red mud poses serious environmental problems wind erosion air water pollution overcome problems effective restoration disposal land naturally growing vegetation sustainable economical approach present study involved estimation frequency density abundance important value index ivi natural flora abandoned sites order assess metal toxicity tolerance capacity based visual observations highest ivi asper punicea identified effective ecological tools restoration barren sites study remarkable differences observed non rhizospheric rhizospheric species rhizospheric analyses confirm ability asper punicea enhancing biological activities abandoned translocation factor iron maximum asper bioconcentration factor bcf found maximum punicea bcf high asper therefore plant could reported iron hyperaccumulator plant results suggest plant species exploited effective restoration deposited land without inputs maintenance
paper concerns automatic welding system digital control directed improvement certain drive guide means relatively freely carried welding wheel rim wheel spider continuous welding part resting freely rotatable table drive guide means carried welding head impart drive part maintaining welding head properly positioned relative part system presented slightly simplified version real automobile wheel welding system although system operation explained terms wheel welding design system much common welding operations utilizing basic industrial automatic welding sequence squeeze weld hold release standby digital control
first quantum private comparison qpc protocol via cavity quantum electrodynamics qed proposed paper making full use evolution law atom via cavity qed third party allowed misbehave conspire either two users proposed protocol adopts two atom product states rather entangled states initial quantum resource needs single atom measurements two users unitary operations quantum entanglement swapping operation necessary proposed protocol proposed protocol compare equality one bit user round comparison one two atom product state proposed protocol resist outside attack participant attack particularly prevent knowing two users secrets furthermore qubit efficiency proposed protocol high
aspects language accent play crucial role formation categorization one cultural identity recent work accent emphasizes role accent person perception social categorization demonstrating accent also serves meaningful indicator ethnic category article investigate whether accent interaction partner marker culture induce cultural frame shifts biculturals report results three experiments performed among bicultural monocultural individuals test hypothesis results demonstrate accent alone affect people cognition
women especially developing countries often responsible managing water household level however rarely represented bodies decide water management hardly play role implementation projects increase water access need enhanced gender equity water management acknowledged international development discourse complexities implementing poorly understood article presents qualitative case study women participation program one million cisterns brazilian semi arid region illustrate promise challenges bringing women participation empowering case study shows women derived significant material benefits program access water also acquired roles responsibilities cistern builders members local water commissions traditionally reserved men key transformational process argue role played local feminist ngos social movements helped rural women create new spaces social inclusion water development elsevier ltd rights reserved
violent behaviour serious problem terms impact victims quality life perpetrators financial burden prison service health sector society generally however date general consensus managed removing perpetrators communities incarceration indeterminate basis short period time reintegration society depending gravity offence systematic review critically examines existing research literature psychotherapeutic interventions violent behaviour forensic clinical populations five databases searched selected journals hand searched authors identified papers contacted efforts obtain relevant unpublished work first author colleague independently evaluated eligibility studies identified abstracted data assessed study quality overall findings provide tentative support utility psychotherapeutic interventions reducing aggressive behaviour forensic psychiatric patients history violent behaviour elsevier ltd rights reserved
objectives individuals essential tremor exhibit range cognitive deficits generally conceptualized dysexecutive fronto subcortical thought reflect disrupted cortico cerebellar networks light emerging evidence increases risk alzheimer disease critical closely examine nature specific cognitive deficits particular attention amnestic deficits may signal early methods performed cross sectional analysis baseline data cases age years enrolled longitudinal clinical pathological study cases underwent comprehensive battery motor free neuropsychological tests functional assessment inform clinical diagnoses normal cognition mild cognitive impairment mci mci dementia mci subdivided subtypes including amnestic single domain mci amnestic multidomain mci non amnestic single domain mci non amnestic multi domain mci results ninety one cases mci within mci mci subtype common followed mci mci mci cases amnestic mci demonstrated lower recognition memory scores non amnestic groups conclusions amnestic mci defined impaired memory recall associated lower memory storage scores frequent mci subtype study impairment explicitly discussed context may early hallmark results implications prognosis specific cognitive deficits
aims study investigated relationship subjective outcome assessment objective parameters intravesical onabotulinumtoxina injection patients overactive bladder oab methods total consecutive patients urodynamically confirmed detrusor overactivity treated intravesical onabotulinumtoxina divided injections normal saline different sites sparing trigone primary end point change global response assessment gra months treatment patients monitored monthly treatment months patients divided successful failed treatment groups according change gra significant improvements oabss months uss oabss urgency urinary incontinence uui urgency episodes months compared patients gra significant difference mbc pvr noted groups months conclusions subjectively successful treatment outcomes intravesical onabotulinumtoxina injection oab patients associated improvement oab symptoms increased bladder capacity wiley periodicals inc
designing programming environments physical simulation challenging simulations rely diverse algorithms geometric domains challenges compounded try run efficiently heterogeneous parallel architectures present ebb domain specific language dsl simulation runs efficiently cpus gpus unlike previous dsls ebb uses three layer architecture separate simulation code definition data structures geometric domains runtimes supporting parallel architectures different geometric domains implemented libraries use common unified relational data model structuring simulation framework way programmers implementing simulations focus physics algorithms simulation without worrying implementation parallel computers geometric domain libraries implemented using common runtime based relations new geometric domains added needed without specifying details memory management mapping different parallel architectures expand runtime interface evaluate ebb comparing several widely used simulations demonstrating comparable performance handwritten gpu code available surpassing existing cpu performance optimizations gpu code exists
reported stress induce depression patient age sex moderating factors associations depression lifestyle korean adults addressed study designed examine relationships among stress problem drinking exercise depression differ age sex study korea health panel data utilized structural equation model using amos employed major findings follows women likely experience stress depression men individuals showed higher tendency toward stress depression age sex specific paths stress problem drinking exercise depression positively inter correlated path exercise depression indicated inverse association results indicate need evidence based stress management programs psychological well korean adults
objective poor sleep known cause detrimental effects course diverse psychiatric disorders putative risk factor hostility aggression thus sleep may crucial forensic psychiatric practice however little known prevalence sleep disturbances complex psychiatric patients methods study investigated presence sleep disorders subjective sleep quality using sleep diagnosis list sdl pittsburgh sleep quality index psqi interviews addressing causes sleep complaints file information sleep medications patients admitted forensic psychiatric hospital results almost participants suffered one sleep disorders especially insomnia even larger proportion participants experienced poor sleep quality interestingly patients antisocial personality disorder traits particularly dissatisfied sleep common causes sleep problems suboptimal sleep hygiene stress ruminating negative sleep conditioning side effects psychotropic medication poor sleepers received hypnotic drug conclusion despite intensive clinical treatment sleep problems experienced large number forensic psychiatric patients would worthwhile examine effects pharmacological non pharmacological sleep interventions psychiatric symptoms reactive aggressive behavior forensic patients elsevier rights reserved
periploca sepium bunge traditional medicinal plant whose root bark important chinese herbal medicine major bioactive compounds steroids periplocin kind cardiac glycoside derived steroid synthesis pathway however research sepium genome transcriptomes related genes lacking long time study estimated species nuclear genome size using flow cytometry rna sequencing four different tissue samples sepium leaves roots adventitious roots calli done using sequencing platform illumina solexa hiseq novo assembly quantitative assessment transcripts unigenes finally generated annotation efforts used number public databases resulted detailed annotation information transcripts addition differentially expressed genes degs identified using digital gene profiling based reads per kilobase transcript per million reads mapped rpkm values compared leaf samples regulated genes regulated genes eventually obtained deepen understanding degs performed two enrichment analyses gene ontology kyoto encyclopedia genes genomes kegg analysis focused upon expression characteristics genes involved terpene metabolic pathway steroid biosynthesis pathway better elucidate molecular mechanism bioactive steroid synthesis sepium bioinformatics analysis enabled find many genes involved bioactive steroid biosynthesis genes encoded acetyl coa acetyltransferase acat hmg coa synthase hmgs hmg coa reductase hmgr mevalonate kinase phosphomevalonate kinase pmk mevalonate diphosphate decarboxylase mdd isopentenylpyrophosphate isomerase ippi farnesyl pyrophosphate synthase fps squalene synthase squalene epoxidase cycloartenol synthase cas sterol methyltransferase smt sterol alpha methyl oxidase smo sterol alpha demethylase cyp sdm delta sterol reductase sterol isomerase hyd sterol alpha methyl oxidase smo delta sterol desaturase ste scdl dehydrocholesterol reductase dwf dhcr delta sterol reductase dwf dhcr sterol desaturase cypa progesterone beta reductase beta por beta hydroxysteroid dehydrogenase beta hsd research helpful understand mechanism bioactive steroid biosynthesis sepium namely steroid periplocin biosynthesis
objectives systematic review aimed explore process variables used stress management intervention smi evaluation research methods systematic review conducted using seven electronic databases studies included reported smi aimed primary secondary stress prevention directed paid employees reported process data two independent researchers checked records selected articles inclusion nielsen randall model process evaluation used cluster process variables three main clusters context intervention mental models results articles included process variables found clustered three main categories context two variables intervention variables mental models variables half articles contained reference process evaluation literature collection process evaluation data mostly took place intervention level employee conclusions findings suggest great heterogeneity methods process variables used process evaluations smi together lack use standardized framework evaluation hinders advancement process evaluation theory development
investigated physical processes molecules properties required case using molecular switches transistors electronic elements future computers studies show molecules biphenyl substituents angle planes phenyl rings depends magnitude applied external electric field ratio squares cosines angles phenyl groups field without field reaches significantly changes ability electrons move along long axis molecule varying nature substituents obtain molecule characteristics make molecules promising future using effect provides use biphenyl substitutes transistors electrical circuits constructed separate molecules
eye contact important successful social interactions dalton nat neurosci doi suggesting gaze avoidance could damaging social functioning gaze avoidance proposed relate higher social anxiety schneier compr psychiatry doi comppsych yet studies utilizing behavioral observation produced mixed findings farabee res personal doi jrpe walters hope behav ther doi weeks soc clin psychol doi jscp goal current study clarify mixed findings literature utilizing clinical sample participants completed interactions another participant assessed eye contact using independent coding participants social anxiety disorder made lower levels eye contact relative participants without social anxiety disorder conversation primed conflict integrating findings previous work theorize social anxiety relates eye contact impairing level social anxiety interaction primed conflict
background aims crohn disease chronic intestinal disorder unknown etiology involving section gastrointestinal tract often associated protein energy malnutrition pem increased resting energy expenditure ree unmatched adequate dietary intake amongst pathogenetic mechanisms proposed pem aim study evaluate ree patients receiving immuno suppressive therapy compared controls methods patients age range years clinically stable without complications since least month studied ree evaluated indirect calorimetry body composition bia full biochemistry performed patients divided two groups group patients without group patients immuno suppressive therapy results two groups similar age height bmi whereas significantly differed weight fat free mass ffm fat mass phase angle degrees serum inflammation parameters significantly higher pcr alfa protein fibrinogen ree higher kcal die men women nevertheless corrected ffm ree resulted higher kcal group also higher compared age sex matched control population ree ffm kcal conclusions preliminary results show ree adjusted ffm increased clinically stable patients mildly reduced immunosuppressive therapy possibly direct action inflammation body composition characteristics authors published elsevier ltd
employment demographic cultural legal changes europe past years brought unprecedented numbers minority groups organisations levels research suggests workplaces likely become even diverse future much attention paid negative experiences minorities workplace also potential important site prejudice reduction response drawing original quantitative qualitative data article explores encounters socially different groups workplace demonstrates workplaces promote meaningful encounters however cases positive encounter difference often discussed level individual reference specific people friendships rather towards minority group individual belonged positive encounters often superficial underlying tensions still existing different groups workplace
power electronic converters single input multiple output simo systems frequency domain distributed power system dps one converter switching frequency ripples another converter perturbations beat frequency components generated due simo characteristics control loops power converters always take high gains low frequency regions beat frequency components relatively low may magnified presented oscillations introduce system instability paper proposes matrix based multifrequency output impedance model describe simo characteristics power converters analyze stability dps buck converter specifically illustrated demonstration proposed model indicates variation switching frequency well traditionally discussed parameters control loops passive components could also change output impedance characteristics introduce system instability dps beat frequency oscillation traditional models fail explain could accurately predicted proposed model addition based proposed model switching frequencies power converters optimized improve stability power electronic based systems simulation experimental results validate accuracy effectiveness proposed method
digital micro controllers processors enable costeffective control grid connected power converter systems terms system monitoring signal processing grid synchronization control grid current voltage control etc normally control implemented micro controller processor fixed sampling rate considering cost complexity number unit delays adopted integer instance conventional digital control systems single phase delay phase locked loop pll system takes unit delays system sampling frequency khz create degrees lagging voltage order achieve grid synchronization orthogonal voltage system however practice grid frequency time variant parameter due various eventualities thus rounding number unit delays delay pll system done implementation process result performance degradation digital control system exactly required number delays realized hence paper virtual unit delay vud proposed address challenges digital delay pll system proposed vud adopts linear interpolation polynomial approximate fractional delay induced varying grid frequency way control performance enhanced proposed vud demonstrated digitally controlled delay pll system experimental results confirmed effectiveness proposal
integrals important many applications ranging physics engineering statistics systematic methods symbolic computation integrals long history computer algebra tools computation parameter integrals recent topic computing definite parameter integrals one necessarily need know explicit antiderivative integrand computations often rely techniques like differentiation integral sign instead
heme oxygenase catalyses degradation heme biliverdin free iron carbon monoxide promoter region contains highly polymorphic repeat shorter repeat sequences linked higher transcriptional activity shown correlate cytoprotective effect higher levels may protect cardiac allograft vasculopathy cardiac allograft recipients transplanted analyzed repeat polymorphism using pcr dna fragment analysis capillary electrophoresis relation cardiac allograft vasculopathy cav analyzed using cox regression including common risk factors cav occurrence rejection episodes explanatory variables total patients analyzed patients positive cav multivariable cox regression analysis short homozygous genotype repeats revealed higher risk cav donor age donor weight significant predictors cav potential risk cav associated rejection episodes history smoking recipient genotype may contribute cav development finding evaluated larger series including studies targeting underlying disease mechanism
analyzes effect submersion formation ochre biofilm geotextile filters used drainage systems chemical microbiological aspects involved ochre formation clogging drainage systems discussed clogging ochre may considered major threat performance filters drainage systems process observed field demonstrated laboratory tests well controlled conditions oxygen needed ochre formation available water air interface filters filters submerged oxygen may also available dissolved water higher concentrations close surface due diffusion process column filter tests introduction iron bacteria three different filter submersion conditions carried woven geotextile filters used tests biofilm formation geotextile filters evaluated analysis eds energy dispersive ray detector scanning electron microscopy ochre formation verified tests confirming ochre formation occur even submerged conditions formation ochre biofilm decreased depth geotextile filter relation water surface following expected reduction available oxygen water surface elsevier ltd rights reserved
multiple animal studies clinical case reports one study observed decreased testosterone production gynaecomastia adverse effect imatinib therapy prospectively studied testosterone fsh levels baseline months imatinib treatment newly diagnosed male bcr abl positive cml patients none patients gynaecomastia months proportion patients low testosterone level increased significantly baseline high fsh increased significantly respectively serum testosterone levels decreased significantly serum fsh levels increased significantly months imatinib therapy comparison baseline levels findings document effect imatinib testosterone levels adult cml patients much reported earlier
theis becoming recurrent concern real terms impending facts yet fully acknowledged note analysis focuses supporting technologies even backdrop situation necessarily mentioned define scenario exploration outlines ecology related results recently discussed series studies authors authors published elsevier ltd
management chronic cardiovascular diseases evolved greatly last decades last thirty years management acute coronary syndrome improved leading important lowering mortality acute phase event consequently optimal management secondary prevention acute coronary syndrome greatly evolved moreover increased number pharmacological alternatives patients affected chronic heart failure non valvular atrial fibrillation reserves number challenges correct management moreover diseases without reasonable doubt largest contributor global mortality present continue future aim study provide updated information real life drug use effectiveness review performed assess potential knowledge gaps treatments diseases indicate potential perspective pharmaco epidemiological research area published elsevier ltd
rhino orbital cerebral mucormycosis rocm rare fulminant opportunistic fungal infection despite relevant treatment high mortality present case year old girl acute lymphoblastic leukemia rocm treated successfully excessive surgery systemic antifungal treatment amphotericin amb posaconazole terbinafine well hyperbaric oxygen surgery included beside extracranial intracranial removal infected areas endoscopic sinus skull base surgery local amb installation addition placement ommaya reservoir intrathecal administrations amb addition review literature rocm pediatric patients hematological diseases
introduction diagnosis treatment syndrome synovitis acne pustulosis hyperostosis osteitis sapho remain difficult describe case series patients sapho response several pharmacological treatments methods clinical biochemical data along medical imaging collected medical records patients diagnosed sapho follow symptoms inflammatory markers recorded twice first patient presentation end follow synovitis acne pustulosis hyperostosis osteitis labeled defining features treatment options categorized according respective responses full remission partial remission disease control results female predominance median age years range years median follow duration months range months total prevalence defining features cohort increased defining feature follow except acne patients reached full partial remission end follow total patients treated bisphosphonates went full partial remission discussion conclusion case series none patients full presentation sapho first consultation presented symptoms suggestive psoriatic arthritis explains diagnosis sapho challenging full remission induced majority individuals bisphosphonates seem noteworthy treatment option suggest prospective placebo controlled clinical trial bisphosphonates confirm observation published elsevier inc
plastic concrete cutoff wall technology successfully applied water control engineering projects higher requirements seepage control quantity quality clay aggregate cement determine appropriateness plastic concrete therefore study laboratory tests four diverse mix designs bentonite sepiolite clay materials conducted determine suitable material concrete increasing clay cement content change observed specimen properties change became obvious increase specimen age increasing silt clay content noticeable reduction compressive tensile strength mechanical properties variation concrete produced sepiolite comparable concrete made bentonite recommended condition available sepiolite material seepage water high contamination improvement modification physical specifications plastic concrete strength permeability metal adsorption reduced cracks increased operating life concrete variety engineering structures published elsevier ltd
system designed protect key data enterprise consists three modules module host information security monitoring auditing module document security management protection module mobile storage management protection constructs multi level security model concerning data security combining authentication authorization management data confidentiality monitoring audit technology protect information throughout life cycle valuable enterprise intranet data protection
detecting epileptic seizure eeg signals constitutes challenging problem significant importance combining adaptive optimal kernel time frequency representation visibility graph develop novel method detecting epileptic seizure eeg signals construct complex networks eeg signals recorded healthy subjects epilepsy patients employ clustering coefficient clustering coefficient entropy average degree characterize topological structure networks generated different brain states addition combine energy deviation network measures recognize healthy subjects epilepsy patients distinguish brain states seizure free interval epileptic seizures three different experiments designed evaluate performance method results suggest method allows high accurate classification epileptiform eeg signals
anterior inferior cerebellar artery aica aneurysms extremely rare accounting intracranial aneurysms average age patients suffering aneurysms found literature years significant difference sexes aneurysms manifest clinically expansive symptoms cerebellopontine angle signs symptoms subarachnoid hemorrhage nausea vomiting headache nystagmus paresis gold standard exam diagnosis cerebral angiography treatment lesions controversial main difficulty surgical treatment aneurysms location aica lies close critical neurovascular structures article describe proximal aica aneurysm embolization without occlusion parent artery excellent results postoperative period
paper analyzes difference useful signal noise signal dissemination characteristic inside wavelet space manufacturing engineering puts forward search algorithm based wavelet decorrelation white noise testing involved parameters parametric equation algorithm select wavelet transform realize best noise reduction effect self adaptive way according characteristic signal containing noise signal noise ratio last simulation experiment engineering application made results compared decomposition result daubechies wavelet concluded self adaptive wavelet basis adequately separate useful information signal
black women likely develop early onset aecurrency years breast cancer lowest five year cause specific survival rate united states racial ethnic group disparities attributed partially higher rate triple negative tnbc blacks yet little known health related quality life hrqol among black women tnbc black women invasive aecurrency years recruited via florida cancer data system part population based case study etiology outcomes early onset invasive consented participants subset self reported sociodemographic clinical psychosocial variables descriptive analyses included participants known tnbc non tnbc disease univariable multivariable analyses conducted examine differences factors associated hrqol unadjusted analyses tnbc participants significantly lower fact total scores compared non tnbc participants tnbc group multivariable analyses indicated five individual level three systemic level factors explain response variation hrqol non tnbc group seven individual level factors three systemic level factors account variation hrqol scores compared black women non tnbc tnbc women worse hrqol key individual systemic level factors unique groups findings inform future hrqol interventions support young black survivors
cold climates freeze thaw cycling important issue engineering freeze cycles translocation water ice caused thermodynamic conditions temperatures degrees changes engineering properties soils previous studies changes physical chemical mechanical properties soils investigated study triaxial compressive tests performed investigate effect freeze thaw cycles strength properties soil reinforced geotextile layer clayey soil reinforced geotextile layer located mid height sample compacted laboratory subjected maximum closed system freeze thaw cycles computerized tomography images also taken samples found investigated soil unconsolidated undrained triaxial compressive strength unreinforced soil decreased increasing number freeze thaw cycles whereas reinforced samples showed better performance strength reduction amount decreased reinforcing soil images shown free water moved soil particles toward lower part soil samples addition found sample reinforcement reduce effect freeze thaw cycles changes cohesion resilient modulus soil elsevier rights reserved
introduction study sought determine symptomatic profile men lower urinary tract symptoms luts visited urology clinic spain impact health related quality life hrql materials methods national epidemiological cross sectional study conducted included urology clinics prevalence storage luts investigated men study collected sociodemographic clinical data subgroup patients storage luts filled international prostate symptom score ipss overactive bladder questionnaire short form oabq patient perception bladder condition ppbc questionnaires impact urinary urgency hrql analysed results prevalence storage luts increasing age patients aged years respectively selected patients storage symptoms exclusively symptom severity ipss increased age nocturia frequency urgency common symptoms impact hrql ipss oabq number urgency episodes inversely correlated hrql multivariate analysis ipss oabq bother scores significant predictors hrql conclusion storage luts highly prevalent among patients attending urology clinics spain severity urgency number urgency episodes predicted poorer quality life patient aeu published elsevier espana rights reserved
article presents case example individual current major depression engaging positive mental imagery intervention specifically computerized cognitive training paradigm involving repeated practice generating positive imagery response ambiguous scenarios patient reported experience intervention suggests potential positive imagery intervention brighten everyday life via promoting involuntary flashes positive mental imagery situations related scenarios associated beneficial effects positive affect future expectations behavior enhancing aspect training involuntary positive imagery contexts adaptive may hold particular promise reducing anhedonic symptoms depression developing simple computerized interventions increase experience positive mental imagery everyday life could therefore provide useful addition drive improve treatment outcomes wiley periodicals inc
objectivesto characterize abnormalities dorsal extensor tendons hand determine importance findings rheumatoid arthritis methodsa retrospective cross sectional study done patients rheumatoid arthritis sonography hands mode power doppler joint activity scored extensor tendons examined mode changes power doppler signals mode changes included anechoic fluid around tendons hypoechoic tissue around tendons paratendon tissue tendon thickening well vascularity around tendon peritendon power doppler signals recorded resultsforty one hands joints reviewed anechoic fluid around tendons peritendon power doppler signals observed respectively patients mode power doppler scores upper tertile respectively mode power doppler scores categories tertiles created reported percentage patients power doppler mode scores category severity synovitis associated anechoic fluid around tendons peritendon power doppler signals according cochran mantel haenszel test common odds ratio confidence interval anechoic fluid around tendons severe synovitis common odds ratio confidence interval peritendon power doppler signals severe synovitis conclusionsfindings dorsal extensor tendons anechoic fluid around tendons hypoechoic tissue around tendons peritendon power doppler signals tendon thickening patients anechoic fluid power doppler signals found severe disease activity joints based mode power doppler scores
graph clustering essential part many methods thus accuracy significant effect many applications addition exponential growth real world graphs social networks biological networks electrical circuits demands clustering algorithms nearly linear time space complexity paper propose personalized pagerank clustering ppc employs inherent cluster exploratory property random walks reveal clusters given graph combine random walks modularity precisely efficiently reveal clusters graph ppc top algorithm reveal inherent clusters graph accurately nearly linear approaches mainly bottom also gives hierarchy clusters useful many applications ppc linear time space complexity superior available clustering algorithms many datasets furthermore top approach makes flexible solution clustering problems different requirements elsevier rights reserved
india state transition massively transformed modern lifestyles one hand influence traditional values customs view current realities urbanization migration globalisation societal transformation mental health treatment needs become complex article highlights existing mental health issues traces development various psychotherapeutic techniques india effort made look basic tenets indian culture bearing conceptualisation practical application psychotherapy indian setting cross cultural relevance adaptability western psychotherapies multi ethnic collectivistic asian culture discussed view differences eastern western approaches mental health challenges culturally responsive adaptations highlighted seen psychological interventions among masses beneficial indigenous approaches based paradigms like themes gita cross fertilized western psychotherapy however need generate empirical evidence indigenization psychological treatments
rapid development electrical network construction urgent need solve problem reasonably planning transmission voltage class sequence transmission network major object study applicable range transmission mode voltage class sequence explored paper firstly fast establishing method proposed given transmission requirement applicable range ehv uhv transmission summarized simulations different transmission scenarios basis combining economical transmission distances voltage class sequence researched suitable transmission schemes selected given transmission scenario based transmission characteristics comprehensive evaluation index system transmission schemes established considered multiple factors including power transmission characteristics reliability economy meanwhile grey comprehensive optimal selection method transmission schemes put forward finally several groups typical transmission scenarios economical transmission schemes established using grey comprehensive optimal selection method evaluation index system optimal one selected comprehensively simulations applicable range transmission voltage class sequence summarized
design conditions research reactor siphon phenomenon induced pipe rupture cause continuous efflux water order prevent water efflux additional facility necessary siphon breaker type safety facility resist loss coolant effectively however analysis siphon breaking complex since comprises two phase flow many inputs considered reason order facilitate analysis design siphon breaker simulation program based fluid mechanics developed using mfc microsoft foundation class programming bernoulli equation velocity quantity well undershooting height water level pressure friction coefficient factors related two phase flow could calculated chisholm model included program analyze two phase flow predict results manner similar obtained real scale experiment modifying values input parameters analyzing results respect loss coolant accident loca locations size pipe coefficients could compared easily since simulation results shown form graph user able confirm total breaking situation furthermore possible save entire simulation results simulation results shown similar obtained real scale experiment program functioned correctly using program user easily able confirm status siphon breaking program also helpful design siphon breaker elsevier ltd rights reserved
objective study causes characteristics outcome treatment patients primary hyperparathyroidism methods retrospective cohort analysis conducted jinnah postgraduate medical centre karachi comprised data patients primary hyperparathyroidism spss used data analysis results patients male female overall mean age years mean duration symptoms years mean pre operative parathyroid hormone level skeletal manifestations reported patients whereas patients renal stone disease besides patients presented severe abdominal pain asymptomatic hypercalcaemia patient presented headache diagnosed parathyroid adenoma context multiple endocrine neoplasia type patients underwent parathyroidectomy solitary adenoma reported patients carcinoma adenoma hyperplasia glands patient conclusion high index suspicion required early diagnosis primary hyperparathyroidism
growing number scientific computation intensive applications calls efficient utilization large scale potentially interoperable distributed infrastructures parameter sweep applications represent large body workflows principle workflows easy conceive execution complex universally accepted solution exists paper focus resource allocation challenges parameter study jobs distributed computing infrastructures cope hard problem high uncertainty present systems propose series job allocation models helps refining simplifying problem complexity way present special cases polynomial show complex scenarios reduced models known practice small number job sizes improves result job allocation therefore state hypothesis relying fact one models unfortunately reduction general problem using means clustering help thus hypothesis proved false future shall look clustering techniques fit goal better
increased availability consumer grade virtual reality head mounted displays hmd created significant demand affordable reliable input devices used control user interfaces accurate positioning user body within virtual environment essential order provide users convincing interactive experiences existing full body motion tracking systems academia industry suffered problems occlusion accumulated sensor error often lacking absolute positional tracking paper describes wireless sensor array system uses multiple inertial measurement units imus calculating complete pose user body system corrects gyroscope errors using magnetic sensor data sensor array system augmented positional tracking system consists rotary laser base station photodiode based tracked object worn user torso base station emits horizontal vertical laser lines sweep across environment sequence known configuration photodiode constellation position orientation tracked object determined high accuracy low latency low computational overhead shown sensor fusion algorithms used result full body tracking system applied wide variety applications interfaces
alzheimer disease represents arguably significant social economic medical crisis time characterized progressive neurodegenerative pathology first foremost condition neuronal synaptic loss repopulation regeneration depleted neuronal circuitry exogenous stem cells therefore rational therapeutic strategy review focus recent advances stem cell therapies utilizing animal models well detailing human clinical trials stem cell therapies currently undergoing development
different design procedures operate mos translinear loops low supply voltage presented utilize innovative biasing strategies based flipped voltage followers floating batteries alternate topology based coupled negative feedback loops also introduced simulation measurement results various test chip prototypes validate proposed techniques allow comparison among
survival following ovarian cancer diagnosis generally low understanding factors related prognosis could important optimize treatment role previously diagnosed comorbidities use medications conditions relation prognosis ovarian cancer patients studied extensively particularly according histological subtype using pooled data fifteen studies participating ovarian cancer association consortium examined associations history hypertension heart disease diabetes medications taken conditions overall survival progression free survival pfs among patients diagnosed invasive epithelial ovarian carcinoma used cox proportional hazards regression models adjusted age stage estimate hazard ratios hrs confidence intervals cis overall within strata histological subtypes history diabetes associated increased risk mortality significant mortality associations observed hypertension heart disease association comorbidities found pfs overall study population however among patients endometrioid tumors hypertension associated lower risk progression comorbidity associated pfs histological subtypes ever use beta blockers oral antidiabetic medications insulin associated increased mortality respectively ever use diuretics inversely associated mortality histories hypertension diabetes use diuretics beta blockers insulin oral antidiabetic medications may influence survival ovarian cancer patients understanding mechanisms observations could provide insight regarding treatment
previously demonstrated serotonin hta receptor htar levels platelets regulated myocardial infarction associated depression study evaluated effects pretreatment ginseng fruit saponins gfs expression htar without depression eighty sprague dawley rats treated saline gfs per group animals randomly divided four subgroups sham depression depression per subgroup protein levels htar serum platelets brain tissues determined elisa results demonstrated serum levels significantly increased gfs pretreatment subgroups except sham subgroup compared saline treated counterparts platelets gfs pretreatment significantly increased levels subgroups compared respective saline treated counterparts brain levels also declined gfs pretreatment depression subgroups saline pretreatment respect htar levels platelet htar decreased gfs pretreated depression depression subgroups saline pretreatment similarly brain htar levels decreased four subgroups pretreated gfs saline pretreatment conclude gfs plays clear role modulating htar expressions depression although effects gfs brain remain elucidated therapeutic potential comorbidities acute cardiovascular events depression appears hold much promise
semantic network approach obsessive compulsive disorder ocd represents new cognitive approach understanding condition dimensional perspective symptoms attempted uncover contamination relevant semantic network unselected undergraduate sample validate purported mechanism association splitting network based intervention symptoms contamination relevant negatively valenced neutral deese roediger mcdermott drm word lists presented accompanied relational item specific semantic processing simulations obsessions association splitting respectively good veridical recognition performance across list types observed simulated obsessions association splitting substantial false recognition rates across critical lure types followed simulated obsessions rates lower simulated association splitting network based accounts contamination relevant findings supported aforementioned research aims additionally enhanced contamination relevant veridical recognition confidence simulated association splitting suggests memory confidence pathway technique might reduce contamination related symptoms lastly contamination relevant recognition performance related contamination related symptom severity across conditions signaling non dimensionality contamination relevant semantic network intensification findings indicate need rigorous research semantic network approach ocd refine tenets association splitting also extensively researched viable technique treating ocd elsevier inc rights reserved
purpose paper presents results national survey pediatric nurse residency programs nrp design methods pediatric nursing certification board pncb database used identify hospitals pediatric units including children hospitals community hospitals pediatric services residency task force institute pediatric nursing ipn developed survey exploring pediatric nurse residency programs survey items addressed structure content outcomes benefits challenges nrps including comparison orientation programs use preceptors results hospitals contacted provided usable information reported nrp hospitals orientation program nrp nrps typically internally developed year length common content included critical thinking stress management small group support professional role transition pediatric resuscitation evidence based practice evaluation nrps included measures satisfaction turnover rates standardized measures primarily casey fink graduate nurse experience survey challenges include obtaining financial support organization developing content relevant across units providing time away clinical units maintaining preceptors benefits noted included development professional role confidence peer support networks increased safe nursing practices decrease nursing turnover conclusions practice implications ongoing development nrps children hospitals issues appropriate content optimal length standardization across settings impact nurse retention safe practice patient outcomes need addressed elsevier inc rights reserved
emerging use wireless multimedia sensor networks wmsns communication facilities increased need network security measures protect different types multimedia data either real time non real time transmission period lot researchers becoming interested secure wmsns due broad application necessities range smart environment security surveillance smart health care requirements secure aggregation multimedia data quality service qos privacy satisfied current technologies proposed security techniques wmsns pros cons security point view explored details addition promising future trends research area giving attention new challenging problems including secure routing protocol fault tolerant robustness recovery process believe paper add significantly valuable discussion among researchers promote fetch new research ideas design approximately best model combining important security issues order reach secure wmsns
first step quantum measurement procedure known premeasurement correlation established system measurement apparatus correlation may classical nonclassical nature one compelling nonclassical correlation entanglement useful resource various quantum information theoretic protocols quantifying amount entanglement generated quantum measurement therefore seeks importance practical ground central issue present paper interestingly two level quantum system obtain amount entanglement measured term negativity generated premeasurement process quantified two factors skew information quantifies uncertainty measurement observable commuting conserved quantity system mixedness parameter system initial state
rapid expansion variable renewable energy wind solar make difficult balance electricity supply demand grid scale much attention focused risk unexpected generation shortfalls periods oversupply supply greater demand also present challenges lead financial losses utilities consumers renewable energy curtailed unique form oversupply occurs hydro dominated systems although hydropower thought offer highly flexible resource complement variable renewable energy seasonal variability streamflows presence environmental regulations create complex oversupply conditions renewable energy plentiful study integrated hydro economic model developed assess frequency severity financial losses arising oversupply pacific northwest hydro dominated system rapidly growing wind power generation present value losses years evaluated several future scenarios including increased wind capacity electricity price uncertainty expanded transmission capacity moving excess electricity export markets results indicate oversupply losses increase function installed wind capacity extent increase sensitive future electricity prices case adding transmission capacity alleviate oversupply losses cost infrastructure substantially associated reduction losses therefore difficult justify elsevier ltd rights reserved
antigen specific immune diseases rheumatoid arthritis often accompanied pain hyperalgesia previous studies demonstrated gamma receptor type fcyri expressed subpopulation rat dorsal root ganglion drg neurons directly activated igg immune complex igg study investigated whether neuronal fcyri contributes antigen specific pain naive rheumatoid arthritis model rats vitro calcium imaging whole cell patch clamp recordings dissociated drg neurons revealed small medium large sized drg neurons responded igg accordingly vivo electrophysiological recordings showed intradermal injection igg peripheral receptive field could sensitize type sensory neurons evoke action potential discharges pain related behavioral tests showed intradermal injection igg dose dependently produced mechanical thermal hyperalgesia hindpaw rats behavioral effects could alleviated localized administration non specific igg fcyri antibody mast cell stabilizer histamine antagonist rat model antigen induced arthritis aia produced methylated bovine serum albumin fcyri found upregulated exclusively small sized drg neurons vitro calcium imaging revealed significantly small sized drg neurons responded igg aia rats although significant difference aia control rats magnitude calcium changes drg neurons moreover vivo electrophysiological recordings showed nociceptive neurons aia rats exhibited greater incidence action potential discharges stronger responses mechanical stimuli igg injected receptive fields results suggest fcyri expressed peripheral nociceptors might directly activated igg contribute antigen specific pain pathological conditions elsevier inc rights reserved
introduction post menopausal phase characterized decline serum oestrogen progesterone levels phase also associated higher incidence peripheral neuropathy aim explore relationship peripheral motor nerve status serum oestrogen progesterone levels assessment motor nerve conduction velocity mncv post menopausal women peripheral neuropathy materials methods cross sectional study conducted jawaharlal nehru medical college study included post menopausal women peripheral neuropathy age post menopausal women without peripheral neuropathy control age compared mncv median ulnar common peroneal nerves serum levels oestrogen progesterone estimated enzyme immunoassays study relationship hormone levels mncv stepwise linear regression analysis done results post menopausal women peripheral neuropathy significantly lower mncv serum oestrogen progesterone levels compared control subjects stepwise linear regression analysis showed oestrogen main effect mncv conclusion findings present study suggest post menopausal age group greater risk peripheral neuropathy decline serum estrogen levels critical development peripheral neuropathy
paper describes dual stroke acting hydraulic power take pto system employed wave energy converter wec inverse pendulum hydraulic pto converts slow irregular reciprocating wave motions relatively smooth fast rotation electrical generator design hydraulic pto system control critical maximize generated power time domain simulation study laboratory experiment full scale beach test presented results simulation laboratory experiments including comparison full scale also presented validated rationality design reliability key components prototype wec inverse pendulum dual stroke acting hydraulic pto system
describe cases skeletal superscan choline pet prostate cancer pca patients cases demonstrated diffuse skeletal involvement besides primary prostate tumor first impression presentation would related diffuse tumoral skeletal invasion pca often seen mdp bone scintigraphy cases bone involvement shown caused hematological disease polycythemia vera chronic myelomonocytic leukemia demonstrating importance also considering presence myeloproliferative syndromes presented diffuse bone disease choline pet performed pca patients
computer programming courses java etc intended non majors facing lot problems cultivating undergraduates abilities computational thinking problem solving students frustrated complex syntax languages confused practical applications paper exploration students abilities cultivations based python teaching practice introduced lesson plan teaching method teaching effect presented detail wish research practice could give hint reform introductory programming courses
risk using child abuse images cai difficult assess especially mostly remains undetected legal authorities present study investigates association aspects sexual preference dynamic risk factors cai mixed offending cai child sexual abuse lifetime within six months prior assessment sample undetected self identified pedo hebephiles investigated multinomial logistic regression analyses revealed sexual preoccupation great importance especially recent cai mixed offending well lifetime mixed offending although inconclusive sexual preference early pubescent children seems interest recent lifetime offending sexual preference prepubescent children additional paraphilias sexualised coping shown although statistically meaningful association lifetime offending gender preference exclusivity pedohebephilia offence supportive attitudes show significant relation offending behaviour
emerging stakeholder needs changing environment drive increasing demands constant adaption software maintenance new capability development evolutionary software engineering approach sought improve engineering responsiveness open system development appears offer partial contribution presents many challenges exploratory research proposes new definition evolution complex engineered systems building essential features openness described cowling lehman ideas evolutionary software using checkland soft system methodology enabled structured literature review analysis relative contributions three divergent methodologies success systems outcomes methodologies plan driven agile open source software development analysis reveals several opportunities highlights critical issue determining return investment needs overcome open approach contribute evolutionary software engineering
washcloth colour indicator appears green immersed skin friendly washing agents around red immersed irritant washing solutions traffic light colour change washcloth helps parents elderly people avoid allergic reactions caused alkaline personal care products washcloth operates fully reversibly thus used multiple times washed without leaching dye chemistry covalently immobilised fabric testing according oekotex product class approves contact babies certifying high stability immobilisation washcloth used proper choice skin care products general dermatology applications
intelligent tutoring systems itss producing consistent learning gains decades however common problem systems maintaining student engagement without reducing learning benefits order balance learning benefits itss motivational benefits games online formative assessment game called tic tac toe quiz single player tris incorporated flowchart based intelligent tutoring system fits benefiting bayesian networks process decision making learning computer programming assessment game combines tic tac toe online assessment revises rule tic tac toe stimulating students use online formative assessment actively finally empirical investigation carried evaluate performance fits indicating considerable gains experimental group control group proposed system extensively enhanced students learning interest attitude degree technology acceptance well improved achievements problem solving activities additionally findings also reveal providing immediate elaborated feedback ief answered question tris optimal design facilitated enhancement programming knowledge acquisition comparing immediate elaborated feedback nief condition elsevier ltd rights reserved
paper presents economical launching accelerating mode including four ordered phases pure electrical driving clutch engagement engine start engine active charging engine driving fit alternating conditions improve fuel economy hybrid electric bus heb typical city bus driving scenarios utilizing fast response feature electric motor adaptive controller designed realize power demand pure electrical driving mode engine starting mode engine active charging mode concurrently smoothness issue induced sequential mode transitions solved coordinated control logic engine clutch simulation experimental results show proposed launching accelerating mode control methods effective improving fuel economy ensure drivability fast transition operation modes heb elsevier ltd rights reserved
traditional digital controls mostly use digital analog converters convert input output voltages digital coding achieve control paper proposes use two digital ramps two different frequencies replace digital analog converter approach produce seven bit resolution dpmw signal addition use digital dll phase correction concept enhance resolution dpwm signal additional three bits resulting bit dpwm signal resolution proposed circuit uses cmos processes core area system switching frequency khz input voltage range output voltage range output voltage measurement accuracy reaches system reaches efficiency output loads elsevier ltd rights reserved
background pharmacy access emergency contraception could involve men pregnancy prevention objectives assess availability cost study design male mystery shoppers visited pharmacies three neighborhoods new york city asked cost noted weekend hours results twenty two pharmacies created barriers get cost higher higher socioeconomic status ses neighborhood higher ses neighborhood pharmacies greater number weekend hours conclusions overall males probability able access national dialogue include males elsevier inc rights reserved
background parasympathetic innervation meninges ability carbachol acetylcholine ach receptor achr agonist induce headaches suggests contribution cholinergic mechanisms primary headaches however neurochemical mechanisms cholinergic regulation peripheral nociception meninges origin place headache almost unknown methods using electrophysiology calcium imaging immunohistochemistry staining meningeal mast cells studied effects cholinergic agents peripheral nociception rat hemiskulls isolated trigeminal neurons results ach carbachol significantly increased nociceptive firing peripheral terminals meningeal trigeminal nerves recorded local suction electrode strong nociceptive firing also induced nicotine implying essential role nicotinic achrs control excitability trigeminal nerve endings nociceptive firing induced carbachol reduced muscarinic antagonist atropine whereas action nicotine prevented nicotinic blocker tubocurarine insensitive trpa antagonist carbachol nicotine induced massive degranulation meningeal mast cells known release multiple pro nociceptive mediators enzymes terminating ach action acetylcholinesterase ache butyrylcholinesterase revealed perivascular meningeal nerves inhibitor ache neostigmine change firing per induced nociceptive activity sensitive tubocurarine pretreatment meninges migraine mediator cgrp observation suggested pro nociceptive action endogenous ach meninges nicotine carbachol induced intracellular transients trigeminal neurons partially overlapping expression capsaicin sensitive trpv receptors conclusion trigeminal nerve terminals meninges well dural mast cells trigeminal ganglion neurons express repertoire pro nociceptive nicotinic muscarinic achrs could activated ach released parasympathetic nerves receptors represent potential target novel therapeutic interventions trigeminal pain probably migraine
latent heat energy storage system one promising solutions efficient way storing excess thermal energy low consumption periods one challenges latent heat storage systems proper selection phase change materials pcms targeted applications compared organic pcms inorganic pcms drawbacks corrosion potential phase separation however available techniques overcome minimize drawbacks hand inorganic pcms found higher thermal conductivity storage capacity organic pcms result inorganic pcms great potential thermal energy storage field especially medium high temperature applications organic pcms viable option study detailed review research outcomes recent technological advancements field inorganic phase change materials presented focusing providing solutions associated disadvantages class pcms long term stability thermal cycling performance heat transfer enhancements also discussed context review
toluene frequently used laser induced fluorescence lif tracer visualizing mixing processes example internal combustion engines signal evaluation relies linear dependence lif signal tracer concentration present many practically relevant cases paper presents investigation dependence lif signal intensities toluene concentration revealing non linear signal response already concentrations approximately ten times given room temperature vapor pressure toluene vaporized mass flow controlled evaporator investigated free jet nitrogen used bath gas variable addition oxygen excitation intensified ccd camera recorded spectrally filtered fluorescence separate experiments effective fluorescence lifetime upon picosecond laser excitation determined results indicate fluorescence lifetime decreases increasing tracer concentration due self quenching results imaging fluorescence lifetime measurements consistent investigation reveals self quenching toluene dominated collisions excited state toluene molecules causes additional dependence magnitude self quenching laser fluence combustion institute published elsevier inc
proposed new method advancing unplugged new process plugged full fledged computer programming languages means deepening understanding computer programming education also proposed new five step method consisting following steps step unplugged activity step plugged activity step trace table step preparing pseudocode step writing java source code
objective persistent concern exists variable possibly inappropriate utilization high cost imaging tests purpose study assess influence appropriate use criteria attributes altering ambulatory imaging orders deemed inappropriate materials methods secondary analysis included medicare imaging demonstration data collected three health care systems via use clinical decision support cds ambulatory imaging order entry cds system captured whether orders inappropriate per appropriate use criteria professional societies provided advice intervention period orders deemed inappropriate assessed impact availability alternative test recommendations conflicts local best practices strength evidence appropriate use criteria primary outcome cancellation modification inappropriate orders expert review determined conflicts local best practices recommendations abdominal thoracic orders strength evidence assessed commonly triggered recommendations deemed inappropriate chi square test used univariate analysis results total imaging test orders deemed inappropriate intervention period amount decreased test orders baseline period inappropriate recommendations alternative test recommendations modified compared four inappropriate recommendations without alternatives seventy eight recommendations conflicted local best practices six inappropriate recommendations conflicted inappropriate recommendations conflicted local best practices modified commonly triggered recommendations oxford centre evidence based medicine level evidence expert opinion conclusion orders imaging tests deemed inappropriate modified infrequently often alternative recommendations present appropriate use criteria consistent local best practices
functional connectivity architecture adult human brain enables complex cognitive processes exhibits remarkably complex structure shared across individuals beginning understand heterogeneous structure ranging strongly hierarchical organization sensorimotor areas widely distributed networks areas parieto frontal cortex study relied functional magnetic resonance imaging fmri data fetuses detectable morphological abnormalities adapting functional magnetic resonance acquisition motion correction nuisance signal reduction procedures resting state functional data analysis fetuses extracted neural activity information major cortical subcortical structures resting fmri networks observed increasing regional functional connectivity gestational weeks gws network based statistical inference approach overall connectivity network short range interhemispheric connections showed sigmoid expansion curve peaking contrast long range connections exhibited linear increase periods peaking development region specific increase functional signal synchrony followed sequence occipital peak temporal peak frontal peak parietal expansion peak successfully adapted functional neuroimaging image post processing approaches correlate macroscopical scale activations fetal brain gestational age vivo study reflects fact mid fetal period hosts events cause architecture brain circuitry mature presumably manifests increasing strength intraand interhemispheric functional macro connectivity
purpose paper propose flexible load dependent digital soft start control method converters vdc system soft start operation needed prevent negative effects large inrush current output overshoot power supply start process converters conventional soft start operation converter slow start deal light load condition therefore always takes long time load condition start power supply obtain desired output proposed soft start control method speed start process flexibly controlled depending load condition obtain optimal speed load condition speed soft start determined approximated function load current estimated experiment results advance proposed soft start control method evaluated simulations experiments results confirmed proposed method superior soft start characteristics compared conventional one
studies design automated canal pool produced fairly good results however designs extended multi pool canals inability eliminate interactions pools caused gate start shutdown paper thus proposes distributed computing gate operation algorithm eliminating water level fluctuation controlling downstream water level canal pools within reasonable range algorithm developed using state space equations derived complete saint venant equations finite difference scheme paper illustrates application control method series pools bounded upstream downstream gates effectiveness control also verified applying laboratory canal wherein soft sensor technique used simplify communication distributed information nodes test results confirmed ability proposed method cope rapid variations water demand maintaining water levels controlled pools copyright john wiley sons ltd
backgroundwhether introduction model end stage liver disease meld effect transplant outcome different age categories remain unclear methodswe analyzed adult hepatitis virus hcv candidates january december scientific registry transplant recipients patients divided four age categories years pre meld era meld era respectively resultswaiting list dropouts decreased meld era categories reduced trend survival observed years patients meld era compared pre meld era year intention treat overall graft survival respectively age categories survival rates superior meld era cox regression analysis showed values hazard ratio age increased advanced age pre meld era compared reference group years hazard ratios overall graft survival meld era conclusionsour study provides useful evidence introduction meld liver allocation may adversely affect survival specific hcv patients
patients suspected hereditary renal cell cancer rcc referred genetic evaluation characterizing prevalence characteristics suspected inherited rcc crucial step toward advancing personalized genetically based cancer risk management patients families evaluate prevalence characteristics suspected inherited rcc syndromes based consensus criteria performed cross sectional analysis patients diagnosis rcc seer institutional cancer registry consensus criteria referral patients rcc genetic evaluation american college medical genetics genomics national society genetic counselors acmg nsgc applied two cohorts associations meeting referral criteria demographic characteristics assessed chi square tests overall seer cohort institutional cohort met acmg nsgc referral criteria genetic counseling white patients commonly met early onset clear cell rcc criteria black patients met papillary rcc criteria twice rate whites cohorts many individuals rcc meet referral criteria genetic evaluation based newly emerging guidelines differences pathology noted race prospective genetic testing studies utilizing emerging referral guidelines help refine genetic spectrum inherited kidney cancer study supports efforts increase awareness referral patients rcc genetic counseling particularly among urologic providers
continuous development peoples life skin care attracting attention many factors affecting skin condition nonlinear correlation factors however current research always use single index evaluate skin condition would accurate article introduce seven key factors affect skin conditions evaluation skin condition classification model built neural network according skin condition index firstly basis age skin condition classified three type youth middle aged old feature kind extracted according seven key factors neural network calculation used study skin condition finally neural network classification result compared real age complete evaluation result proves using method article introduced classification skin condition similarity real age neural network evaluate skin condition effectively addition method simple practical supplies effective way evaluation physical significance evaluation clear uses difference information maximum accurate effective way obtain skin condition information
minimal research explores impact career dementia care senior health professionals study sought positive negative subjective interpretations seven senior health professionals regarding experiences dementia care data semi structured interviews analysed using interpretative phenomenological analysis ipa one superordinate theme honouring stigmatised self overarched four sub themes systemic stigma invalidated self respect moral integrity growth stigma interpreted systemically entrenched minimisation aged care aged care workforce including poor remuneration training participants experienced peer invalidation particularly attempting resolve complex professional moral challenges dementia care often occurred context efforts individualise care constrained within medical model paradoxically external invalidation motivated search redefining self moral integrity wisely acknowledging career experience growthful domains self respect optimism humility innovation defined professional practice personal choices implications discussed
little information gender differences general mental health smoking drinking chronic diseases chinese elderly examined gender differences general mental health smoking drinking number chronic diseases large chinese old population multistage stratified cluster sampling used cross sectional study total people women men aged years included general mental health smoking drinking chronic diseases recorded standardized assessment tools multivariate analyses revealed women less likely current smokers frequent drinkers higher prevalence poor mental health compared male counterparts addition prevalence rate chronic diseases multi morbidities higher women men values health professionals policy makers need pay special attention common chronic diseases poor mental health older women higher prevalence smoking drinking men
research contact hypothesis highlighted role contact improving intergroup relations research addressed problem transforming prejudices historically advantaged communities thereby eroding wider patterns discrimination inequality present research drawing evidence cross sectional survey conducted new delhi explored alternative process contact may promote social change namely fostering political solidarity empowerment amongst disadvantaged results indicated muslim students experiences contact disadvantaged communities associated willingness participate joint collective action reduce shared inequalities relationship mediated perceptions collective efficacy shared historical grievances moderated positive experiences contact hindu majority implications recent debates relationship contact social change discussed copyright john wiley sons ltd
gamma spectrometric field measurements may provide high resolution information topsoil texture yet calibrations estimation texture data usually done site specifically lack site independent calibrations thus limits easy universal use proximal gamma ray sensing soil mapping precision agriculture objective develop study site independent prediction model topsoil texture gamma ray spectra surveyed ten study sites across germany reference samples calibration test set validation providing soils broad range parent materials widely varying soil texture first study site specific models calibrated linear regression approach models provided reliable estimations sand silt clay study sites second study site independent models calibrated via linear regression support vector machines svm latter mathematical methods data pattern recognition based non linear relationship gamma spectrum soil texture varied widely different parent materials linear models appropriate satisfactory soil texture prediction averaged sand silt clay averaged absolute prediction errors respectively contrast svm calibrated prediction models revealed reliable performance also site independent calibrations non linear svm approach able include sites one single prediction model texture fraction although different mineralogical composition parent materials led complex partly opposing relationships gamma features soil texture site independent predictions via svm often even better site specific linear regression models site independent svm calibrated predictions yielded averaged sand silt clay corresponding averaged absolute prediction errors respectively summarize non linear prediction models feasible approach capable site independent texture estimations across wide range soils gamma spectrometry based texture predictions valuable input applications require highly resolved texture information low costs efforts elsevier rights reserved
three year field experiment conducted determine integrating different furrow applied mulches would influence yield water use efficiency wue corn zea mays cultivated plastic covered ridge furrow rainwater harvesting prfrh system semi arid lands china loess plateau effect mulching treatments combination prfrh compared conventional flat control furrow applied mulching treatments designation none bare furrow liquid film biodegradable film thick layer corn stover thick plastic film corn planted furrows either side plastic covered ridges plots treatments though soil moisture measured gravimetrically auger samples taken locations plot intervals depth years soil moisture storage depth significantly higher indicating mulching likely reduced soil evaporation losses suggesting integrated prfrh mulch systems potential increase crop sustainability semiarid region
studied three hybrid poplar plantations quebec canada established sites varying soil environmental characteristics investigate effects logging residues water potential carbon isotope ratio foliar nutrients planted trees site four treatments representing different residue loads well treatments aimed manipulating specific factors environment herbicide geotextile applied test effects seedling water potential carbon isotope ratio foliar nutrients along analyses variance used structural equation modelling infer causal relationships logging residues height basal diameter foliar nutrition trees effects soil temperature soil water content competing vegetation cover logging residues decreased soil temperature sites woody plants cover one site three height basal diameter unit leaf mass strongly related foliar delta concentration unit leaf mass increased decreasing cover woody plants suggesting important role competition resources overall logging residues direct influence hybrid poplar dimensions two growing seasons effects microenvironment resource demanding tree species either cancelling significant enough significant impact growth drivers measured example presence logging residues might reduce soil temperature impeding overall seedling performance study highlights fact given silvicultural method aimed manipulating logging residues complex influence involving interaction multiple environmental drivers net effect tree productivity depend species site specific conditions
little known offending behavior recidivism factors latinos nativity born foreign born present study focused latinos community corrections miami florida examined differences criminal activity drug use mental health nativity data collected utilizing convenience sampling june december research question offending drug use mental health histories latinos involved community corrections participants mostly male white cuban born community corrections clients likely report lifetime recent criminal activity likely report lifetime recent drug use behavior foreign born latinos differences found recent mental health correctional healthcare tailor services substance abuse treatment differently toward born foreign born latinos
background decompression sickness dcs potential danger risk divers aircrew alike dcs also potential side effect altitude hypobaric chamber training well present long training occurs literature review shows altitude chamber induced dcs approximately incidence case report old active duty military member developed symptoms dcs hypobaric chamber training unfortunately seek treatment dcs exposure initial treatment included ground level oxygen therapy min oxygen per minute using nonrebreathing mask achieved complete symptom resolution returned duty however initial flight medicine evaluation patient returned complaining right temporal headache multijoint pains fatigue treated hyperbaric chamber complete resolution symptoms returned flying status later denied return symptoms discussion hypobaric chamber familiarity training requirement military aircrew personnel allow assess ability identify symptoms hypoxia training method costly maintain also places aircrew chamber technicians risk potential long term side effects failed recompression treatment dcs presenting case recurrent dcs symptoms initial ground level oxygen therapy
estrogen withdrawal following menopause results increase osteoclasts formation bone resorption one important mechanisms postmenopausal osteoporosis recently growing evidence suggested receptor interacting protein implicated estrogen regulated metabolic disease including fat metabolism lipid metabolism however little known regarding role receptor interacting protein regulation bone metabolic estrogen present study western blotting disclosed estrogen brings significant increasing expression receptor interacting protein osteoclasts osteoblasts bone marrow mesenchymal stem cells furthermore analysis trap staining bone resorption assay showed depletion receptor interacting protein could significantly alleviate inhibitory effects estrogen osteoclasts formation bone resorption activity moreover estrogen could induce osteoclasts apoptosis increasing receptor interacting protein expression fas fasl pathway taken together receptor interacting protein might critical player estrogen mediated osteoclastogenesis bone resorption
exposure adversity childhood including domestic violence parental mental illness loss poverty known risk factor long term physical mental health problems secondary data analysis uses national survey children health examine association exposure family adversity academic outcomes mediated child mental health analytic sample included children ages six representative child population family adversity mediated child mental health status negatively associated school engagement positively associated retained grade individualized education program male gender family economic hardship living unsafe neighborhood poor caregiver mental health additional risk factors results suggest need improved mental health screening students exhibit internalizing externalizing symptoms
one challenge hcv elimination therapeutic intervention reinfection aim analysis calculate incidence hcv reinfection among hiv positive hiv negative individuals treated recent hcv infection estimated infection duration months individuals recent hcv infection achieved end treatment response four open label studies australia new zealand assessed hcv reinfection confirmed sequencing core nsb regions reinfection incidence calculated using person time observation exact poisson regression analysis used assess factors associated hcv reinfection cohort risk reinfection male median age years composed hiv positive men sex men people inject drugs current ever total follow time risk person years median years range ten cases hcv reinfection identified incidence per reinfection incidence significantly higher among participants reported injection drug use end post treatment irrespective hiv status per adjusted analysis factors associated reinfection older age airr injection drug use end post treatment airr high reinfection incidence following treatment recent hcv infection individuals ongoing risk behaviour emphasizes need post treatment surveillance harm reduction strategies education risk populations
internet based relapse prevention supplement adolescent substance abuse treatment programming promising modality reinforce treatment gains enhance recovery however evidence base lacking assess efficacy online navigating journey nmj program adolescent aged participants ages receiving substance abuse treatment participated randomized parallel group study comparing two conditions experimental nmj versus attention control viewed wellness articles nemours foundation discretion participants experimental condition asked complete core lessons months lesson content developed teach evidence based relapse prevention skills data collected four time points baseline month follow month follow month follow used linear mixed modeling approach test differences conditions outcome participants experimental condition reported significantly greater increase motivation reduce misuse drugs baseline month follow baseline month follow compared control participants participants experimental condition also reported greater decrease drug use score baseline month follow compared control participants analysis age potential moderator suggested intervention may effective older adolescents greater use program associated greater self efficacy lower self reported substance use time relapse prevention treatment adolescents may facilitated theory based online interventions nct
paper propose first provable secure certificate based proxy signature cbps message recovery without bilinear pairing gentry introduced concept certificate based cryptography solve certificate management key escrow problems public key infrastructure identity based cryptosystems respectively overall cost pairing computation higher scalar multiplication elliptic curve group consequently cbps schemes without pairings would efficient according available research regard scheme first provable secure cbps scheme message recovery based elliptic curve discrete logarithm problem prove security presented scheme random oracle model existential forgery adaptive chosen message attacks moreover paper also show would possible convert scheme cbps scheme without message recovery scheme applications cases constrain power restricted bandwidth copyright john wiley sons ltd
model transformations constitute key technology model driven software development software engineering discipline became important last decade tool support unidirectional batch transformations rather mature bidirectional incremental transformations weakly investigated nevertheless several usage scenarios demand incremental bidirectional transformations like round trip engineering uml class models java source code paper presents bidirectional transformation uml class models java model obtained java source code transformation written qvt relations declarative model transformation language provided omg case study demonstrates possible specify bidirectional transformations heterogeneous metamodels single relational specification also reveals inherent limitations language corresponding tool support
publication describes developed general model vehicle power network matlab developed model includes significant components electrical network alternator rectifier loads battery designed form sub models vehicle power network model modular design single sub models replaced easily quality developed model verified comparison simulation results measurement results test bench modeling every single component sub model alternator sub model excitation current control well functioning principle vehicle power network simulated automotive typical test case described detail following publication
investigated relationship functional insertion deletion polymorphism angiotensin converting enzyme ace gene risk nicotine dependence croatian schizophrenia patients also tested whether interactions ace polymorphism smoking status affected clinical psychopathology findings patients measured using positive negative symptom scale panss scores polymerase chain reaction analysis used genotype chronically ill schizophrenia patients males females significant differences distribution ace genotypes alleles male female schizophrenia patients stratified based smoking status however trend toward difference ace genotype distribution female smokers nonsmokers chi due mainly significant overrepresentation ace heterozygous genotypes female smokers compared nonsmokers ace heterozygous females twofold higher smoking risk ace ace homozygous carriers observed contribution ace genotype smoking interaction panss psychopathology first study investigate possible association ace polymorphism nicotine dependence schizophrenia results suggest ace polymorphism may relevant determining risk nicotine dependence female patients schizophrenia ace genotype smoking interaction contribute clinical expression schizophrenia
integrated photo bioelectrochemical ipb system innovative integrating microbial fuel cells mfcs algal bioreactors simultaneous organics degradation nutrient removal bio energy production mathematical model developed simulating understanding performance ipb system model inputs include influent cod chemical oxygen demand total phosphorus external resistance flow rate outputs include biomass growth cod degradation nutrient removal electricity generation determination unknown model parameters assisted sensitivity analysis satisfactory model fitting validation achieved low root mean square error respectively biomass concentration current generation varied cod input simulated results suggested organic input flow rate significant impacts growth algal biomass input factors cod flow rate external resistance importance current generation optimal condition improving particular ipb system predicted cod concentration flow rate min ipb model first attempt kind optimization integrated bioprocess electrochemical reactions algal growth elsevier ltd rights reserved
purpose review although uromodulin tamm horsfall protein discovered years ago functional role humans remains unclear review highlights new studies elucidating clinical correlates uromodulin association kidney function decline nephrolithiasis urinary host defense recent findings uromodulin evolutionarily conserved multiple functional roles large population studies higher levels uromodulin associated higher estimated glomerular filtration rate egfr kidney size possibly indicating greater kidney functional reserve greater uromodulin excretion associated markers volume overload fractional excretion uric acid sodium chloride indicating possible role salt water retention recent evidence also suggests higher uromodulin levels associated lower risk egfr decline death possibly lower risk acute kidney injury higher levels uromodulin associated lower risk urinary tract infections older adults serum uromodulin levels positively associated egfr although functional role remains unclear summary last decade begun understand functional role uromodulin health disease large prospective studies generalizable populations needed confirm preliminary results evaluate clinical utility measuring uromodulin examine whether levels biomarker altered therapeutic benefit
although tyrosine kinase inhibitors tkis dramatically improved clinical outcome chronic myeloid leukemia cml cure rarely occurs may due bcr abl independent aberrant signaling pathways one leads leukotriene formation well recognized inflammatory mediators also affect oncogenic mechanisms several tumors previously discovered elevated synthesis regulated cysteinyl inducing enzyme cml report dose dependent inhibition cml cell growth exerted specific blockers signaling thus cysteinyl receptor antagonist montelukast significantly reduced growth kcl cells well primary blood cells two cml patients adding montelukast tki imatinib caused combined inhibition effect seen normal bone marrow cells similarly growth inhibition also observed lipoxygenase inhibitor bwac activating protein flap inhibitor licofelone ltb blt receptor antagonist thus blocking aberrant signaling may provide additional novel therapeutic possibility cml
addition buffering plants water stress severe droughts plant water storage pws alters many features spatio temporal dynamics water movement soil plant system pws impacts water dynamics drought resilience explored using multi layer porous media model model numerically resolves soil plant hydrodynamics coupling leaf level gas exchange soil root interfacial layers novel features model considerations coordinated relationship stomatal aperture variation whole system hydraulics effects pws nocturnal transpiration night hydraulic redistribution soil model results suggest daytime pws usage night generate residual water potential gradient night along plant vascular system overnight night represents non negligible competing sink strength diminishes significance considering occurrence pws usage single extended dry wide range plant attributes environmental soil conditions selected enhance suppress plant drought resilience discussed compared model calculations suggest increased root water influx plant conducting tissues overnight maintains favorable water status leaf thereby delaying onset drought stress
background controversy exists regarding possible correlation periodontal disease rheumatoid arthritis ankylosing spondylitis confounding factors may relate stringency inflammatory disease diagnosis effect therapeutic intervention periodontal disease factors investigated study methods forty five individuals documented spondyloarthropathy calcium pyrophosphate deposition disease cppd hamann todd collection human skeletons compiled individuals contemporarily incorporated collection examined tooth loss cavity occurrence average maximum lingual buccal depth space tooth bone periosteal reaction serpentine bone resorption abscess formation root penetration bone surface analyzed analysis variance results tooth loss common actual number teeth lost cavity occurrence average maximum lingual buccal depth space tooth bone periosteal reaction serpentine grooving surrounding teeth considered sign inflammation abscess formation root exposure penetration bone surface indistinguishable among controls individuals spondyloarthropathy cppd conclusions although many factors affect periodontal disease presence inflammatory arthritis appear one implication dental disease common general population necessarily associated arthritis least advent modern rheumatologic medications specific diagnosis affect prevalence perhaps current prevalence controversy may relate current intervention subject study
aimed compare efficacy tolerability mirtazapine versus ssris assess whether non response week may clinical indicator combining mirtazapine ssris subsequent treatment one hundred fifty four outpatients mdd randomized receive mirtazapine ssris step weeks non responders step randomly assigned either mirtazapine ssris monotherapy combination step ila responders step continued monotherapy step ilb weeks step mirtazapine showed significantly faster improvement shown higher remission rate week nnt compared ssris somnolence rate higher mirtazapine nausea rate higher ssris step ila combination therapy showed favorable time course ssris monotherapy subjects taking ssris step combination therapy showed significant better improvement hamilton depression rating ham score week ssris monotherapy responders week could reach remission week non responders could reach remission week patients continued monotherapy mirtazapine added ssris non responders week remission rate increased ham score improved points mirtazapine non responders ssris add equally effective mirtazapine may provide faster improvement non response week may indicator mirtazapine add patients receiving ssris elsevier ltd rights reserved
cogeneration systems employed many years various heat power applications micro combined heat power mchp system advanced miniature version cogeneration system expected play major role curbing emissions increasing primary energy savings near future residential sector significant consumer electrical energy petroleum based fuels paper reviews recent studies related research development micro combined heat power mchp systems proposed investigated residential applications salient features prime mover energy conversion device used systems marketing potential developments presented elsevier ltd rights reserved
prior research indicates may disharmonious relationship positive attitudes toward ethnic cultural diversity social identity within socially dominant group recent work cultural psychology however implied disharmonious relationship may confined specific representation social identity research examined possibility study found negative association national identity diversity attitudes found among participants western societies extend participants non western societies study recruited american japanese participants disentangled two distinct representations social identitycollective relational social identityand found differential associations positive attitudes toward multiculturalism implications discussed
binge eating episodes characterized uncontrollable distressing eating large amount highly palatable food represent central feature bingeing related eating disorders research suggests inflammation plays role onset maintenance eating related maladaptive behavior markers inflammation selectively altered discrete brain regions directly indirectly regulate food intake present study measured expression levels different components cytokine systems tnf alpha ifn gamma related molecules inos cox preoptic anterior tuberal parts hypothalamus validated animal model binge eating animal model based exposure food restriction frustration stress binge like eating behavior highly palatable food shown animals exposed frustration stress estrus phase found characteristic regulation receptor system increased expression inhibitor pro inflammatory cytokine together decreased expression binding chain receptor three fold increase expression inos specifically anterior tuberal region hypothalamus animals develop binge like eating behavior differently food restricted animals stressed estrus phase expression increased inos expression significantly affected considering role region hypothalamus controlling feeding related behavior relevant eating disorders obesity data suggest targeting centrally selected inflammatory markers may prevent disordered eating turns full blown eating disorder elsevier rights reserved
objectivesto investigate urodynamic efficacy safety mirabegron add treatment tamsulosin japanese male patients overactive bladder oab methodsa prospective study conducted consecutive male patients oab taking tamsulosin oab diagnosed overactive bladder symptom score oabss weeks mirabegron add treatment preceding tamsulosin assessed oabss international prostate symptom score ipss free uroflowmetry ufm filling cystometry pressure flow study pfs resultsmean age prostate volume study patients years respectively mirabegron significantly improved oabss free ufm mirabegron significantly increased voided volume maximum sec average flow rate sec postvoid residual urine volume change significantly mirabegron patients detrusor overactivity mirabegron add maximum cystometric capacity significantly increased disappeared six patients patients persistent amplitude involuntary contraction decreased bladder volume first involuntary contraction increased statistical significance pfs detrusor pressure maximum flow rate cmh bladder contractility index change significantly conclusions mirabegron add treatment tamsulosin efficacy safety improves storage symptom without impairment bladder contractility voiding male patients oab
laboratory scale physical modelling conducted understand behaviour highway embankments constructed peat foundations artificial transparent soil used simulate deformation properties peat foundation use transparent soil allows determination spatial deformations underneath modelled embankment using particle image velocimetry piv load settlement behaviour field reasonably simulated laboratory scale physical model paper presents results modelled embankment geotextile fabric across base
realizing long distance quantum key distribution qkd fiber channel classical optical communications quantum signals multiplexed different wavelengths attracted considerable attentions achievable secure distance commonly used bennet brassard protocol lowered severely due inevitable crosstalk classical optical pulses unlike conventional quantum key distribution qkd protocols round robin differential phase shift rrdps qkd protocol high tolerance noise since potential information leakage protocol bounded without monitoring signal disturbance thus may promising protocol noisy channel work investigate performance achievable secure distance rrpds protocol crosstalk classical communication considered surprisingly find rrpds quite limited advantage protocol optical misalignment qkd system serious misalignment trivial even outperform rrdps protocol
one ways making pavements high quality making amendments consumption bitumen final asphalt mixture would higher quality order use tropics aim study study sbs polymer order modify properties polymer modified bitumen sbs bitumen characteristics lack bitumen qualifications modification led procedural failures caused heat tropics regions obviously bitumen characteristics modification cause produce higher quality asphalts order use pavement tropical regions producing kind asphalts maintenance costs highways reduced research attempted various methods remove drawbacks technical assessment evaluate effect sbs polymer bitumen properties include two types tests bitumen tests asphalt tests research comparison effects polymer amount penetration softness density degree bitumen also asphalt examined since currently challenging perfectly achieve expected polymer modified bitumen properties time compromised recommendations given paper among greatly enhancing properties acceptably high cost significantly reducing cost relatively poor properties combinations iase publisher rights reserved
background multiple sclerosis allergies considered related imbalanced thl immune responses previous studies evaluating relationship allergies provide conflicting results objective assess allergies asthma risk factors predictors relapses pediatric cohort methods environment genetic risk factors pediatric study national case control project participating sites environmental questionnaire used includes history allergies first five years life case control data entered pediatric network database cases sites enter relapse data prospectively annualized relapse rate calculated patients follow adjusted age disease onset gender race ethnicity use disease modifying therapy dmt results included cases mean age disease onset years female controls relapse data available cases difference prevalence allergies asthma cases controls patients food allergies fewer relapses compared patients without food allergies conclusions allergies asthma associated pediatric cases food allergies fewer relapses compared without food allergies elsevier rights reserved
paper presents control method lcl filter implemented three phase voltage source grid connected inverter offering better attenuation switching harmonics also highly damping resonance discrete time deadbeat current controller tuned state feedback gains proposed realize time optimum responses high control accuracy addition influences different grid inductances switching frequencies three level type inverter controller gains discussed analytical design three dimensional deadbeat controller dealing instantaneous space vectors examined varying grid inductance effectiveness optimum feedback gains control performance validated experimentally deadbeat controller provide fastest response damp resonance lcl filter relatively low switching frequency comparison filter size
primary goal research design electrical generation control system small scale solar thermal collector optimized pacific northwest project team collected data existing solar thermal system worked design power conversion system generate electricity design implementation generator prime mover electric load controller discussed paper
study presents several meet middle attacks reduced round crypton mcrypton block ciphers using generalised set authors construct round distinguishers crypton mcrypton based distinguishers authors propose meet middle attacks round crypton mcrypton attack crypton needs chosen plaintexts encryptions bit blocks attacks mcrypton need chosen plaintexts encryptions bit blocks furthermore attack extended rounds mcrypton complexities chosen plaintexts encryptions bit blocks
virago press published women craft richardson one editors contributed interview gaie davidson called crocheted strategies new audience women work book outcome feminist arts news craft issue raised number questions relative status crafts arts value level derived women assigned status artist turn emerged feministo postal art project instigated kate walker women trained art schools richardson monica ross walker communicated media domestic crafts sewing knitting crochet represent lives work within home alexandra kokoli curator exhibition richardson work burnt breakfast works wrote press release title richardson homemade objects explore domesticity femininity mutual implication distinctly feminist point view exhibition included iconic crocheted full english womanly skill crochet used grain express humorous manner growing dissatisfaction patriarchal gender roles also challenge hierarchical division art craft article explores relevance ideas context recent resurgence craft particularly textiles particularly amongst indie crafters activists able refer feminist histories practices yet feel bound hand handcrafting mobilized statement domestic roles firmly based within language empowerment enacted collaborative practice based work encompassing several disciplines social media public engagement forty years another kind news crafts community propelled social media renewed interest politics crafting necessarily crafting politics
water pollution pharmaceutically active compounds emerging issue toxicological studies reveal pharmaceuticals indeed toxic living organisms lack suitable treatment technology complete removal pharmaceuticals therefore major challenge advanced oxidation processes emerging removal techniques many advantages versus conventional technologies many studies indicate advanced oxidation processes either single combination degradation techniques enhance degradation pharmaceuticals aqueous solutions review degradation pharmaceuticals sonolysis oxidation processes using ultrasound technique hydroxyl radicals generated pyrolytic cleavage water molecules review influence operational parameters additives hybrid techniques degradation pharmaceuticals maximum degradation organic compounds observed frequency range khz high frequency medium power ultrasound even though almost experiments presented removal good biodegradability target compound good mineralization toxicity removal hardly achieved efficiency degradation varies water matrixes varying major pathways degradation hydroxylation dehalogenation demethylation decarboxylation deamination etc hybrid techniques developed scale application ultrasound
arts bots combines intrinsically creative craft materials common robotics components custom programming environment teacher professional development create flexible robotics intervention secondary school classrooms order engage students underserved robotics programs arts bots oriented support creation collaborative expression focused robots opposed commonly implemented competitive task focused robot activities specifically arts bots targets integration traditional nontechnical classes literature history reach broader base students would enrolled elective technology programs paper describes three classroom implementations including secondary school poetry project including arts bots core courses expose diverse students engineering education activities hands experiences computer programming prototyping engineering design process present outcomes grouped within two primary themes first technological fluency present students self reporting concepts learned confidence technology breaking technology stereotypes second complementary non technical skills present skills students learned participating arts bots program
paper introduces panel threshold model empirically estimate main drivers electricity performance empirical analysis based panel data set including oecd countries period argue effective regulatory reforms positive interaction electricity generated leading higher capacity utilization increase level labor productivity sector threshold analysis suggests already economically liberalised countries level economic freedom affect electricity generation subsequently level electricity performance finally results drastically change renewable energy sources res taken account
water crisis one supreme challenges worldwide clean water ultimate need human civilization life earth present study continuous adsorption experiments carried adsorption column survey efficiency carbon nanotubes cnts removal pollutants water wastewater terms physicochemical parameters electrical conductivity total dissolved solids tds chemical oxygen demand cod total organic carbon toc using single walled carbon nanotubes multi walled carbon nanotubes sample solutions allowed flow flow mode fixed bed cnts cnts column showed reduction efficiency electrical conductivity effluent treatment plant etp treated water sample raw effluent sample synthetic salt water sample similarly efficiency tds reduction raw effluent sample etp treated water sample synthetic salt water sample cod also reduced raw effluent sample etp treated water sample case toc column showed reduction efficiency etp treated water sample raw effluent sample findings suggested cnts present great potential removal pollutants terms physicochemical parameters water wastewater
well known laser scanner better accuracy stereo vision detecting distance velocity obstacles whereas stereo vision distinguish objects better laser scanner advantages sensor maximized sensor fusion approach obstacles front detected accurately paper high level sensor fusion laser scanner stereo vision developed object matching sensors time synchronization object age reordering algorithms designed robust tracking objects time delay update algorithm also developed determine process time delay laser scanner expanded laser scanner data every predicted kalman filter matched stereo vision data every cost function formulated describe object matching similarity sensors best matching candidate selected theminimumcost function proposedmatching algorithms verified experimentally field tests various maneuvering cases
objective identify effective strengthening exercise programs provide rehabilitation teams patients updated high quality recommendations concerning traditional land based exercises knee osteoarthritis methods systematic search adapted selection criteria included comparative controlled trials strengthening exercise programs patients knee osteoarthritis panel experts reached consensus recommendations using delphi survey hierarchical alphabetical grading system based statistical significance clinical importance improvement results high quality studies identified demonstrated various strengthening exercise programs without types therapeutic exercises generally effective improving knee osteoarthritis management within six month period strengthening exercise programs demonstrated significant improvement pain relief four grade ten grade two grade physical function four grade eight grade quality life three grade strengthening combination types exercises coordination balance functional showed significant improvement pain relief three grade grade eight grade physical function two grade four grade three grade quality life one grade one grade conclusion variety choices strengthening exercise programs positive recommendations healthcare professionals knee osteoarthritis patients need develop combined behavioral muscle strengthening strategies improve long term maintenance regular strengthening exercise programs
present study examined police officers social workers experiences investigating child sexual exploitation cse cases impact welfare semi structured interviews conducted frontline social workers law enforcement professionals practitioners reported seldom reacted emotionally forensic interviews attending entirely victims gathering evidence although practitioners employed post interview stress management techniques anticipatory coping strategies seldom adopted coping methods employed outside workplace spending time family practitioners focused needs young people almost exclusion many consider negative emotional impact cse cases welfare findings important implications practitioner wellbeing copyright john wiley sons ltd
research shown exposure violent video games causes increases aggression mechanisms effect remained elusive also potential differences short term long term exposure well understood initial correlational study shows video game violence exposure vve positively correlated self reports aggressive behavior relation robust controlling multiple aspects personality tab experiment showed individuals low vve behave aggressively playing violent video game nonviolent game high vve display relatively high levels aggression regardless game content mediational analyses show trait hostility empathy hostile perceptions partially account vve effect aggression findings suggest repeated exposure video game violence increases aggressive behavior part via changes cognitive personality factors associated desensitization
background eosinophils contribute pathogenesis multiple diseases including asthma treatment antibodies targeting receptor reduces frequency asthma exacerbations eosinophil receptors share common chain csf receptors recently reported potent gmcsf maintaining erk psk rps ribosome directed signaling pathway leading increased protein translation objective aimed determine disease relevant consequences prolonged eosinophil stimulation results human blood eosinophils used establish impact activation igg driven eosinophil degranulation compared continuing exposure induced degranulation eosinophils aggregated igg via increased production activation low affinity igg receptor alpha beta integrin addition unlike csf induced expression cdb fcgriib subtype proteins without changing cda fcgriia protein cdb mrna expression levels importantly vitro induced modifications recapitulated vivo airway eosinophils conclusions clinical relevance observed first time upregulation cdb eosinophils identified potent inducer alpha beta mediated eosinophil degranulation
evaluate potential role dual energy dect visualize antiangiogenic treatment effects patients metastatic renal cell cancer mrcc treated tyrosine kinase inhibitors tki patients mrcc underwent baseline follow single phase abdominal contrast enhanced dect scans scans performed immediately weeks start treatment tki virtual non enhanced vne colour coded iodine images generated metastases measured two time points hounsfield unit values vne iodine density well iodine content tissue derived values compared venous phase dect density ctd lesions values treatment compared using paired student test baseline follow mean ctd dect derived showed significant reduction relative reduction measured percent significantly greater ctd also significantly reduced antiangiogenic treatment dual energy based quantification iodine content mrcc metastases allows significantly sensitive reproducible detection antiangiogenic treatment effects aeuro cent sign tumour response antiangiogenic treatment reduced tumour perfusion aeuro cent dect allows visualizing iodine uptake serves marker vascularization aeuro cent sensitive detection antiangiogenic treatment effects mrcc possible
paper presents work area sensing using smart materials specific dielectric electro active polymers deaps sensing one main trio characteristics deaps trio formations applicable uses actuator transducer finally sensor noted one main value propositions whenever deap material used dual characteristics sensing actuating capability following work deap membrane modeled relation among key variables pressure capacitance determined hence relation depends geometrical shape used membrane development process carried propose alternative solutions sensor design using deap laminate material test methodology pressure based test rig prototypes software developed afterwards evaluate prototypes test pieces general deap material proven good sensor pressure taking advantage flexibility wide range operation finally sensitivity theoretical model benchmarked acquired data tests whereby high correlation within approximate range mmhg mean error observed showing promising application deap material pressure sensing general demonstrating feasibility conceptualization blood pressure sensing system based deap material
evolution manufacturing technology definitive indicator human society development wheels started spree world machines revolutionized manufacturing processes manufacturing tools indicative eras development paper focused branch engineering deals manufacturing specifically structure india study investigate premier government institutes respect manufacturing engineering education also included technical education model different education level
mammals suprachiasmatic nucleus scn hypothalamus site main circadian clock synchronized light dark cycle generates behavioral rhythms like feeding drinking activity notwithstanding main role scn clock control circadian rhythms questioned due presence clock activity many brain areas including implicated regulation feeding reward moreover whether circadian rhythms particular motivated behaviors exist unknown evaluated spontaneous daily circadian behavior consumption sweet caloric solution sucrose effects sucrose intake expression clock genes mouse brain mice showed daily light dark cycle circadian constant darkness conditions rhythm intake sucrose preference rise parameters night subjective night addition observed changes circadian day night expression clock gene per scn cortex striatum animals ingesting sucrose compared control mice pure water finally daily rhythms sucrose intake preference abolished per brdm double per per brdm mutant animals data indicate expression circadian rhythms hedonic feeding behaviors may controlled brain circadian clocks per gene expression ibro published elsevier ltd rights reserved
background atmospheric ultrafine particles ufps pesticide rotenone considered potential environmental risk factors parkinson disease however whether ufps alone combination rotenone affect pathogenesis remains largely unknown methods ultrafine carbon black ufcb surrogate ufps rotenone used individually combination determine roles chronic dopaminergic loss neuron glia neuron enriched mix glia cultures immunochemistry using antibody tyrosine hydroxylase performed detect neuronal loss measurement extracellular superoxide intracellular reactive oxygen species ros performed examine activation nadph oxidase genetic deletion pharmacological inhibition nadph oxidase mac receptor microglia employed examine role neuronal loss triggered ufcb rotenone results rodent midbrain neuron glia cultures ufcb rotenone alone caused neuronal death dose dependent manner particularly ufcb doses induced significant loss neurons importantly nontoxic doses ufcb rotenone induced synergistic toxicity neurons microglial activation essential process furthermore superoxide production microglial nadph oxidase critical ufcb rotenone induced neurotoxicity studies mix glia cultures showed ufcb treatment activated microglial nadph oxidase induce superoxide production firstly ufcb enhanced expression nadph oxidase subunits phox phox phox secondly ufcb recognized microglial surface mac receptor consequently promoted rotenone induced phox phox translocation assembling active nadph oxidase conclusion ufcb rotenone worked synergy activate nadph oxidase microglia leading oxidative damage neurons findings delineated potential role ultrafine particles alone combination pesticide rotenone pathogenesis elsevier inc rights reserved
status implementation undergraduate tutorial system domestic foreign studied paper taking metallic materials engineering specialty technological university example authors proposed mode undergraduate tutorial system named team tutorial system team tutorial system refers teachers formed current science research group offer common guide two dormitories students implementation practice technological university proved team tutorial system played positive role cultivating students quality innovation ability due comprehensive advantages various types tutorial system
background plasma derived pasteurized inhibitor inh concentrate berinert decade history use hereditary angioedema hae substantial literature base demonstrates safety efficacy thromboembolic events rarely reported inh products typically label use supratherapeutic doses objectives active surveillance safety clinical usage patterns pasteurized inhibitor concentrate recent pasteurized nanofiltered inh particular interest thromboembolic events methods registry initiated april sites obtain prospective retrospective safety usage data subjects administered inh berinert results may data available subjects infusions subject using inh demand therapy demand therapy prophylactic administration approximately half infusions administered prophylaxis given patient caregiver home setting total adverse events reported overall rate events per infusion considered related inh two thromboembolic events reported patients prothrombotic risk factors conclusion large pool real world clinical usage data hae supports extensive safety profile berinert formulations used demand prophylaxis home andhealth care settings noevidence foundto suggest berinert independent causative risk factor thromboembolic events american academy allergy asthma immunology
compact model amorphous indium gallium zinc oxide thin film transistors suitable cad simulators proposed model simple symmetric accurately accounts subthreshold linear saturation regimes via unique formulation accounts trapped free charges means multiple trapping release percolation conduction band aim paper work analytic expression current terminal charges along surface potential electric field function position channel availability surface potential electric field key model advanced physical effects example carrier injection electrodes channel
background role amitriptyline musculoskeletal pain clearly defined classical neuropathic pain conditions objective assess efficacy effectiveness amitriptyline treatment pain musculoskeletal complaints methods extensive search including medline embase web science made april randomised controlled trials amitriptyline musculoskeletal complaints compared placebo usual care analgesic use included studies assessed risk bias outcomes interest pain reduction function improvement results articles identified seven finally included studies performed patients low back pain rheumatoid arthritis patients arm pain repetitive use meta analysis performed due clinical heterogeneity studies two studies low risk bias found positive results one study found day amitriptyline visual analogue scale vas points resulted significantly greater reduction pain treatment pregabalin day vas points improved function improvement oswestry disability index versus amitriptyline improved function arm pain compared placebo upper extremity function scale versus similar amount side effects occurred amitriptyline comparison groups conclusion studies evaluated use amitriptyline musculoskeletal complaints although amitriptyline may effective musculoskeletal complaints studies required establish amitriptyline works better analgesics
background use topical nsaids treat acute musculoskeletal conditions become widely accepted provide pain relief without associated systemic adverse events review update topical nsaids acute pain adults originally published issue objectives determine efficacy safety topically applied nsaids acute musculoskeletal pain adults search methods searched cochrane register studies online medline embase february sought unpublished studies asking personal contacts searching online clinical trial registers manufacturers websites earlier review also searched house database contacted manufacturers selection criteria included randomised double blind active placebo inert carrier controlled trials treatments administered adults acute pain resulting strains sprains sports overuse type injuries twisted ankle instance least participants treatment arm application treatment least daily data collection analysis two review authors independently assessed studies inclusion extracted data used numbers participants achieving outcome calculate risk ratio numbers needed treat additional beneficial outcome nnt additional harmful outcome nnh compared placebo active treatment reported confidence intervals particularly interested compare different formulations gel cream plaster individual nsaids main results update added new included studies participants excluded four studies also identified additional reports completed ongoing studies published full earlier review included studies update included studies compared topical nsaids form gel spray cream similar topical placebo participants treated topical nsaid placebo oral nsaid increase number included participants previous version review also identified number studies clinical trial registries unavailable results amounting participants efficacy adverse events formulations topical diclofenac ibuprofen ketoprofen piroxicam indomethacin demonstrated significantly higher rates clinical success participants least pain relief matching topical placebo moderate high quality data benzydamine three drug formulation combinations nnts clinical success diclofenac emulgel formulation lowest nnt two studies using least pain intensity reduction outcome diclofenac plasters flector also low nnt based good excellent responses studies ketoprofen gel nnt five studies less well defined outcomes ibuprofen gel nnt two studies outcomes marked improvement complete remission drug formulation combinations nnt values indicating lesser efficacy insufficient data compare reliably individual topical nsaids oral nsaid local skin reactions generally mild transient differ placebo high quality data systemic adverse events high quality data withdrawals due adverse events low quality data authors conclusions topical nsaids provided good levels pain relief acute conditions sprains strains overuse injuries probably similar provided oral nsaids gel formulations diclofenac emugel ibuprofen ketoprofen diclofenac patches provided best effects adverse events usually minimal since last version review new included studies provided additional information particular information topical diclofenac greatly expanded present review supports previous review concluding topical nsaids effective providing pain relief goes demonstrate certain formulations mainly gel formulations diclofenac ibuprofen ketoprofen provide best results large amounts unpublished data identified could influence results updates review
soil degradation one serious ecological problems world arid semi arid northern china soil degradation predominantly arises wind erosion trends soil degradation caused wind erosion northern china frequently change human activities climatic change decrease soil loss wind erosion enhance local ecosystems chinese government encouraging residents reduce wind induced soil degradation series national policies several ecological projects natural forest protection program national action program combat desertification three norths shelter forest system beijing tianjin sand source control engineering project grain green project implemented number decades ago thus created many land management practices control techniques across different landscapes measures include conservation tillage windbreak networks checkerboard barriers non watering tube protecting planting technique afforestation grassland enclosures etc result aeolian degradation land controlled many regions arid semiarid northern china however challenge mitigating reversing soil degradation caused wind erosion still remains
shifting fossil fuel dominated energy system sustainable hydrogen economy could mitigate climate change reduction greenhouse gas emissions estimated fossil fuels remain significant part energy system mid century bridge technologies use fossil fuels environmentally cleaner way offer opportunity reduce warming impact continued fossil fuel utilization methane cracking potential bridge technology transition sustainable hydrogen economy since produces hydrogen zero emissions carbon dioxide however methane feedstock obtained natural gas releases fugitive emissions methane potent greenhouse gas may offset methane cracking benefits work model exploring impact methane cracking implementation hydrogen economy presented impact global emissions carbon dioxide methane explored results indicate hydrogen economy potential reduce global carbon dioxide equivalent emissions methane leakage natural gas relatively low methane cracking employed produce hydrogen hydrogen fuel cell applied wide range result differences scenarios leakage rates used scenarios hand methane leakage natural gas relatively high methane steam reforming employed produce hydrogen internal combustion engine applied hydrogen economy leads net increase global carbon authors published elsevier ltd behalf hydrogen energy publications llc
research indicates affect influences whether people focus categorical behavioral information impression formation one explanation affect confers value whatever cognitive inclinations accessible given situation three studies tested malleable mood effects hypothesis predicting happy moods maintain unhappy moods inhibit situationally dominant thinking styles participants completed impression formation task included categorical behavioral information consistent proposed hypothesis fixed relation mood processing emerged whether happy moods led judgments reflecting category level behavior level information depended whether participants led focus immediate psychological state current affective experience studies physical environment unexpected odor study consistent research socially situated cognition results demonstrate affective state trigger entirely different thinking styles depending context
representing digital objects structured meshes embed coarse block decomposition relevant problem applications like computer animation physically based simulation computer aided design cad one key ingredients produce coarse block structures achieve good alignment mesh singularities corners block paper improve polycube based meshing pipeline produce surface volumetric coarse block structured meshes general shapes aim add new step pipeline goal optimize positions polycube corners produce coarse possible base complexes rely mapping positions corners integer grid using integer numerical programming reach optimal best knowledge first attempt solve singularity misalignment problem directly polycube space previous methods polycube generation specifically address issue corner optimization strategy efficient requires negligible extra running time meshing pipeline paper show optimized polycubes produce coarser block structured surface volumetric meshes compared previous approaches also induce higher quality hexahedral meshes better suited spline fitting reduce number splines necessary cover domain thus improving efficiency overall level smoothness throughout volume
paper presents proof concept graphical models approach assessing moral coherence moral robustness systems social interactions moral coherence refers degree rights duties agents within system effectively respected agents system comply rights duties recognized force relevant context interaction moral robustness refers degree system social interaction configured ensure interests agents effectively respected even face noncompliance using case conscientious objection pharmacists filling prescriptions emergency contraception example illustrate graphical models approach help stakeholders identify structural weaknesses systems social interaction evaluate relativemerits alternate organizational structures illustrating merits graphical models approach hope spur developments area
background utilization diagnostic information national patient registries rests quality registered diagnoses aimed investigate agreement consistency diagnoses psychotic bipolar disorders norwegian patient registry npr compared structured interview based diagnoses given part clinical research project methods diagnostic data npr obtained period patients included thematically organized psychosis top study diagnostic statistical manual mental disorders edition dsm diagnosis schizophrenia delusional disorder schizoaffective disorder bipolar disorder diagnostic agreement primary dsm diagnosis top international classification diseases revision icd diagnoses npr evaluated using cohen unweighted nominal kappa diagnostic consistency calculated proportion registered severe mental disorder diagnoses npr equivalent primary diagnosis given top study results proportion patients registered equivalent icd diagnosis primary dsm diagnosis given top schizophrenia group delusional disorder group schizoaffective disorder group bipolar disorder group diagnostic agreement good schizophrenia bipolar disorder fair schizoaffective disorder poor delusional disorder among patients dsm schizophrenia diagnosed icd bipolar disorder among patients dsm bipolar disorder diagnosed icd schizophrenia diagnostic consistency schizophrenia delusional disorder schizoaffective disorder bipolar disorder conclusions compared research based diagnoses clinical diagnoses schizophrenia bipolar disorder npr accurate consistent minimal diagnostic overlap two disorders
current ambitions limit climate change degrees degrees end century rely heavily availability negative emissions technologies nets bioenergy capture storage beccs direct air capture particular context nets providing specific service removing atmosphere therefore investors would expect appropriate risk adjusted rate return varying function quantity public money involved uniquely beccs facilities possibility generate low carbon power remove atmosphere energy system characterised high penetration intermittent renewable energy wind solar power plants dispatch load factor beccs facilities may small relative capacity potential significantly utilise assets primary purpose removing atmosphere study present techno economic environmental evaluation beccs plants range operating efficiencies considering full part load operation relative national scale annual removal target find cases lower capital cost lower efficiency beccs plant superior higher cost higher efficiency facility environmental economic perspectives show may preferable operate beccs facility base load fashion constantly removing atmosphere dispatching electricity needed basis show use spare capacity produce hydrogen injection natural gas system provision low carbon heating add overall environmental economic benefit system point hypothesis appears break emissions associated biomass supply chain sufficiently large eliminate service removal
food drug administration approval ruxolitinib treatment myelofibrosis polycythemia vera changed management patients myeloproliferative neoplasms yet impact therapy risk thrombosis major cause morbidity mortality among patients remains unknown aim study evaluate impact ruxolitinib risk thrombosis among patients polycythemia vera myelofibrosis following identification randomized controlled trials comparing ruxolitinib standard care placebo rates thrombosis including venous arterial thrombosis analyzed using fixed effects models rates thrombosis significantly lower among patients treated ruxolitinib risk ratio confidence interval subgroup analysis venous arterial thrombosis demonstrated similar risk ratios reach statistical significance risk ratio respectively conclusion analysis suggests jak inhibition ruxolitinib decreases risk arterial venous thrombosis patients polycythemia vera myelofibrosis findings require confirmation prospective study copyright wolters kluwer health inc rights reserved
emerging hepatitis virus hcv resistant strains considered main drawback available drugs since hcv large inactive surface would like hypothesis mutation occur hcv minimal causing less resistance inhibition study short peptide inhibitor hcv namely plectasin identified hcv serine protease assay plectasin peptide showed considerable inhibition hcv serine protease enzymatic activity recombinant apro analysed fluorescence release several fluorogenic peptide substrates resembling dibasic cleavage site sequences flavivirus polyprotein precursor amc labelled peptides pyr rtkr amc efficiently cleaved substrate lowest value kinetic assay showed plectasin peptide inhibited apro activity value compared aprotinin standard proteases inhibitor results plectasin peptide also demonstrated dose dependent inhibition hcv replication considerable reduction rluc activity using hcv replicon containing huh cells study identified unique natural peptide used highlight novel structures development drug derivatives high efficacy hcv protease inhibitors
paper highlights essential pillars schema therapy well outlining basic concepts early maladaptive schemas domains emotional core needs mode model present overview important features schema therapy look special schematic therapeutic relationship work thereby focusing emotional processes needs oriented biography work age appropriate psycho education schema coaching parents clinical recommendations given based recent evidence
early childhood caries ecc common preventable disease childhood affect children health wellbeing children migrant families may greater risk developing ecc objective describe ecc children migrant families explore possible influences basic research design cross sectional analysis caries data collected baseline data oral health promotion study participants analysis sample included year old children clustered within iraqi lebanese pakistani families melbourne australia method child participants received community based visual dental examination parents completed self administered questionnaire demographics ethnicity oral health knowledge behaviour attitudes main outcome measure child caries experience bivariate associations oral health behaviours ethnicity tested significance using chi square multivariate logistic regression analyses performed identify associations ecc adjusting demographic variables accounting clustering family results overall children sample experienced caries non cavitated cavitated caries lesions parent length residence australia consumption sweet drinks parental education remained independent predictors child caries experience adding sugar drinks additional risk factor cavitation ethnicity associated individual oral health behaviours suggesting cultural influences health however relationship independent predictors conclusion culturally competent oral health promotion interventions aim support migrant families young children focus reducing sweet drink consumption
paper propose three dimensional metamaterial absorber based tailored resistive film patch array numerical results show broadband abs orption achieved ghz either transverse electric magnetic polarization wave normal incidence field surface current power loss density distributions absorber investigated explain physical mechanism high absorption addition absorption efficiency oblique incidence also elucidated according analysis field power loss density distributions explain absorption differences mode oblique incidence proposed metamaterial absorber pave way practical applications sensing imaging stealth technology importantly design idea ability extended terahertz infrared optical region elsevier rights reserved
ethnopharmacological relevance cancer proceeded surpass one chronic illnesses major cause mortality developing developed world garcinia mangostana mangosteen family guttiferae known queen fruits one popular tropical fruits cultivated southeast asian countries malaysia indonesia sri lanka burma thailand philippines traditionally numerous parts mangostana utilized treat various ailments abdominal pain haemorrhoids food allergies arthritis leucorrhoea gonorrhea diarrhea dysentery wound infection suppuration chronic ulcer aim study although anticancer activity reported plant goal study designed isolate characterize active metabolites mangostana measure cytotoxic properties research mechanism antiproliferative cytotoxic effects tested compounds investigated materials methods chcl fraction air dried fruit hulls repeatedly chromatographed sio diaion polyamide columns furnish fourteen compounds structures metabolites proven nmr measurements hresims additionally cytotoxic potential compounds assessed mcf hct hepg cell lines using srb assay antiproliferative cell cycle interference effects potentially potent compounds tested using dna content flow cytometry mechanism cell death induction also studied using annexin differential staining coupled flow cytometry results chcl soluble fraction afforded two new xanthones mangostanaxanthones along twelve known compounds mangostanaxanthone beta mangostin garcinone alpha mangostin mangostin garcimangosone aromadendrin beta glucopyranoside tetrahydroxybenzene trihydroxybenzophenone beta glucopyranoside maclurin beta glucopyranoside rhodanthenone epicatechin pentahydroxybenzophenone compound showed considerable antiproliferative cytotoxic effects ranging compounds showed moderate weak cytotoxic effects ranged using dna content flow cytometry found induced significant cell cycle arrest phase indicative antiproliferative properties additionally using annexin fitc differential staining induced cells killing effect via induction apoptosis necrosis hepg hct cells compound produce necrosis apoptosis hct cells contrary induced apoptosis necrosis hepg cells moderate necrosis hct cells conclusion fourteen compounds isolated chloroform fraction mangostana fruit hulls cytotoxic properties exhibited isolated xanthones mangostana reinforce avail natural cytotoxic agent various cancers evidences could provide relevant bases scientific rationale using mangostana anti cancer treatment
paper analyses dynamic behaviour seismic isolation technology adopted foundations towers two recent long span bridges consisting dissipative layer granular soil placed contact foundation caisson group foundation piles fundamental aspects isolation device studied three dimensional modified newmark model accounts multi directionality seismic motion includes simplified description dynamic response superstructure simplified model expressed rigorous non dimensional formulation validated results three dimensional dynamic analysis soil structure interaction specific case suspension bridge taking advantage non dimensional formulation simplified dynamic model parametric study general validity carried highlights significant factors influencing performance dissipative device authors published elsevier ltd
background mean age patients chronic hepatitis virus hcv infection usa increasing despite increasing proportion hcv infected elderly patients group represented clinical trials hcv treatment aim aimed describe real world effectiveness direct acting antivirals daas among elderly patients patients methods retrospectively identified hcv infected patients started treatment sofosbuvir ledipasvir sofosbuvir paritaprevir ombitasvir ritonavir dasabuvir based regimens veterans affairs healthcare system january june ascertained sustained virologic response svr rates patients aged years older performed multivariable logistic regression determine whether age predicted svr results overall unadjusted svr rates confidence interval patients aged years older unadjusted svr rates similar age groups stratifying genotype treatment regimen stage liver disease treatment experience multivariate models age predictive svr adjusting confounders conclusion daas produce high rates svr age groups including patients oldest age category years advanced age considered barrier initiating daa treatment copyright wolters kluwer health inc rights reserved
objective multiple surveys show patients want medical privacy however costs maintaining privacy also risks information shared review previous surveys found surveys asked questions patient privacy concerns willingness share medical information found one study asked sharing medical information better care survey asked patients risk cost comparison medical privacy privacy areas fill gap designed survey compare medical privacy preferences privacy preferences areas measure willingness pay cost additional privacy measures measure willingness accept risks sharing information methods total patients attending physician offices sites completed part anonymous questionnaire results patients willing share medical information treating physicians difference willingness share primary care specialty sites including psychiatry hiv clinic survey difference sharing preference standard medical information information additional legal protections including genetic testing drug alcohol treatment hiv results medical privacy ranked lower sharing social security credit card numbers deemed private information including tax returns handgun purchases statistical difference questions site except hiv aids clinic patients ranking privacy medical record important reducing high medical costs risk medical errors patients willing spend modest amount additional time privacy willing pay additional medical privacy patients unwilling take additional risks keep medical information hidden conclusions patients willing share medical information providers able see importance sharing medical information provide best possible care unwilling hide information providers increased medical risk patients willing spend additional time privacy unwilling spend extra money sixty eight percent patients favored reducing medical costs privacy
method post processing velocity pressure projection developed helps maintain stability resolved inviscid discontinuous element based simulation use environmental fluid mechanics process studies post processing method needed spurious divergence growth element interfaces due discontinuous nature discretization used spurious divergence eventually leads numerical instability previous work shown discontinuous element local projection onto space divergence free basis functions capable stabilizing projection method discontinuity inherent technique may lead instability resolved simulations enforcing inter element discontinuity requiring divergence free result weak sense new post processing technique developed simultaneously improves smoothness reduces divergence pressure projected velocity field time compared non post processed velocity field post processed velocity field remains stable far longer exhibits better smoothness conservation properties elsevier ltd rights reserved
human body odor source important social information study explore whether sex individual established based smelling axillary odor whether exposure male female odors biases chemosensory social perception double blind pseudo randomized application healthy normosmic heterosexual male female raters exposed male female chemosignals odor samples heterosexual donors collected cardio workout odor sample recipients rated chemosensory samples masculinity femininity scale provided intensity familiarity pleasantness ratings additionally modulation social perception gender neutral faces personality attributes affective introspection mood male female chemosignals assessed male female axillary odors rated rather masculine regardless sex donor opposed masculinity bias odor perception femininity bias modulating social perception appeared facilitated femininity detection gender neutral faces personality attributes male female chemosignals appeared chemosensory effect mood rater observed results discussed regards use male female chemosignals affective social communication
football players violent impacts injuries athlete sport concussion mild traumatic brain injuries one lesser known sports injuries last decade advent modern technologies medical engineering disciplines people aware concussion detection prevention concussions often overlooked football players cumulative effect mild traumatic brain injuries cause long term residual brain dysfunctions principle concussion based movement brain neurocranium viscerocranium brain encapsulated cerebrospinal fluid acts protective layer brain fluid protect brain minor movements however rapid movements brain may mitigate protective capability cerebrospinal fluid paper propose wireless health monitoring helmet addresses concerns current monitoring methods non invasive football player helmet additional gear efficient performance equipped eeg nanosensors accelerometer restrict movement user wirelessly communicates remote monitoring station requirement individual monitoring stations required player zigbee protocol couple multiple transmitters one receiver helmet developed validated according mentioned parameters
present paper discusses endoscopic diagnosis treatment years demand gastroenterologist services growing driven partly aging population popularity screening colonoscopy hopefully along better genetic fecal markers allow colonoscopy used much efficiently patients really need innovations reduction pressure patients decreasing diameter electron endoscope particularly transnasal endoscope continued parallel development research capsule endoscopy tentative measure issues regarding perform screening test medical expenses established contrast highly precise imaging techniques progressing important theme endoscopic medicine prevalence development therapeutic endoscopy situation gastroesophageal reflux disease obesity hemostasis luminal stenosis endoscopic submucosal dissection early gastrointestinal cancer stenting endoscopic shincterotomy natural orifice translumenal endoscopic surgery pancreatic biliary diseases addition field gastroenterology gastrointestinal endoscopy need evolve one digestive health sciences new multidisciplinary specialty required department digestive diseases integrating specialists field
variety operating systems application programs internet weak points terms security intelligent attacks weak points spreading rapidly causing lot damage particular files downloaded use application programming interface intermediate interface operating systems application programs running time attacks weak points application programs made principle users infected malicious codes disguised process updating security patches therefore work tries propose system integrity security patch updating using fts patch management file transfer system
social disinhibition difficulties common following traumatic brain injury tbi however clinically sensitive tools objectively assess difficulties lacking study aimed pilot new clinical measure social disinhibition social disinhibition task sdt whether social disinhibition dependent type social information judgements required whether disinhibited responses adjusted additional guidance also examined participants adults male moderate severe tbi adult male healthy control participants participants viewed scenes complex social situations asked describe character part describe character inhibiting inappropriate negative responses part describe character inhibiting negative responses also providing positive responses part one half items contained faux pas requiring participants make inferences character smental state tbi control participants responded similarly part although control participants responded less positively tbi participants faux pas items tbi participants significantly impaired part indicating experienced difficulties inhibiting automatic responding tbi participants however able adjust responding part respond similarly control participants group differences detected reaction time overall sdt appears suitable detect social inhibition difficulties clinical settings provides new direction remediation difficulties individuals tbi
aims objectivesto explore describe parents preterm sick infants neonatal care perceive sleep backgroundparents experience many stressful situations newborn infant preterm sick affects bonding developing family centred care units single family rooms parents given opportunity stay care newborn infant hours day lack sleep may affect new parents ability cope many challenges face daily basis designa phenomenographic study inductive exploratory design methodssemi structured interviews conducted twelve parents infants neonatal care january march describe variations perception phenomenon data analysed using phenomenography findingsfour descriptive categories identified within phenomenon sleep parents preterm sick infants neonatal care impact stress sleep environment affects sleep keeping family together improves sleep parents manage prevent tiredness conclusionanxiety uncertainty powerlessness negative influence sleep decreased continuous information guidance practical support skin skin care perceived stress reducing factor improved relaxation sleep encouraged nurse parents also mentioned importance together private place could relax take care newborn infant improved sleep also desirable involve older siblings order decrease feelings loneliness sadness isolation relevance clinical practiceimproved parental sleep neonatal care may help families cope situation facilitate problem solving emotional regulation transition parenthood
computer aided materials design increasingly importance interest conventional approach solely relying experimentation longer viable within constraint available resources calphad approach emerged first approach calculation phase equilibria thermodynamic properties complex multi component multi phase systems recent years applied broader field materials science engineering beyond phase diagrams solidification coating joining phase transformation approach therefore plays important role modern materials design framework integrated computational materials engineering study present modeling approach integrates thermodynamic calculation kinetic simulation simulate precipitation kinetics multi component alloys applications demonstrated studies number nickel based alloys
steam gasification processes energy conversion pathway organic materials converted useful energy spite high energy content organic waste materials mostly disposed landfills causes harmful environmental issues methane emissions ground water pollution contaminations sense organic solid waste materials regarded alternative resources conversion useful energy steam gasification process study three types waste materials municipal solid waste msw used tires sewage sludge used generate syngas gasification process degrees steam atmosphere syngas generation rates chemical compositions measured evaluated time determine characteristics dynamics gasification process also carbon conversion mass energy balances presented demonstrates feasibility steam gasification waste conversion pathway results show syngas contains high concentrations around volume syngas generation rate found depend carbon content feedstock regardless types input materials comparing hydrogen production water splitting requires extremely high temperatures around degrees hydrogen production steam gasification organic materials regarded equally effective requires lower system temperatures copyright john wiley sons ltd
chylothorax defined presence chyle pleural cavity central vein thrombosis recognized cause chylothorax adult population commonly related central venous catheterization case illustrates patient aids disseminated tuberculosis left chylothorax central vein thrombosis month antituberculosis therapy case patient advanced seminoma presented left chylothorax central vein thrombosis chemotherapy chylothorax resolved anticoagulation cases case lymphoma patient central vein thrombosis developed chylothorax chemotherapy chylothorax resolved continuation anticoagulation recur despite progressive underlying lymphoma central venous catheterization three cases cases illustrate unique association central vein thrombosis chylothorax importance anticoagulation management
humans drastically altered abundance animals marine ecosystems via exploitation reduced abundance destabilize food webs leading cascading indirect effects dramatically reorganize community structure shift ecosystem function however additional implications top changes biogeochemical cycles via consumer mediated nutrient dynamics cnd often overlooked marine systems particularly coastal areas review research underscores importance bottom control local regional global scales coastal marine ecosystems potential implications anthropogenic change fundamentally alter processes focus attention two primary ways consumers affect nutrient dynamics emphasis implications nutrient capacity ecosystems storage retention nutrients biomass supply nutrients via excretion egestion nutrient storage consumer biomass may especially important many marine ecosystems consumers opposed producers often dominate organismal biomass nutrient supply emphasize consumers enhance primary production press pulse dynamics looking forward explore importance cdn improving theory ecological stoichiometry metabolic theory biodiversity ecosystem function relationships context global environmental change increasing research focus cnd likely transform perspectives consumers affect functioning marine ecosystems
deployment ambient intelligence ami paradigm requires designing integrating user centered smart environments assist people daily life activities research paper details integration validation multiple heterogeneous sensors hybrid reasoners support decision making order monitor personal environmental data smart home private way results innovate knowledge based platforms distributed sensors connected objects accessibility authentication methods promote independent living elderly people talisman ami framework deployed integrates four subsystems smart home mobile biomedical telemonitoring platform provide elderly patients continuous disease management integration middleware allows context capture heterogeneous sensors program environment reaction iii vision system intelligent monitoring daily activities home ontologies based integrated reasoning platform trigger local actions manage private information smart home framework integrated two real running environments upm accessible digital home metaltic house successfully validated five experts home care elderly people personal autonomy
cluster consisting group computers act whole system provide users computer resources computer node cluster cluster computer refers system consisting complete set computers connected rapid development computer technology cluster computing technique high performance cost ratio widely applied distributed parallel computing large scale close data group enterprise heterogeneous data integration model built cluster environment based cluster computing xml technology ontology theory model could provide users unified transparent access interfaces based cluster computing work solved heterogeneous data integration problems means ontology xml technology furthermore good application effect achieved compared traditional data integration model furthermore proved model improved computing capacity system high performance cost ratio thus hoped provide support decision making enterprise managers
idiopathic pulmonary fibrosis ipf involves collagen deposition results progressive decline lung function process involves activation smad transforming growth factor tgf beta wnt signaling pathways collagen triple helix repeat containing cthrc protein inhibits smad activation test hypothesis cthrc limits collagen deposition decline lung function cthrc knockout cthrc wild type mice received intratracheal injections bleomycin saline lungs harvested days bronchoalveolar lavage bal tgf beta beta hydroxyproline lung compliance assessed tgf beta significantly higher cthrc compared saline injection bleomycin injection increased tgf beta cthrc hydroxyproline significantly higher cthrc compared bleomycin injection immunohistochemistry cthrc lung sections showed intracellular localization activation catenin areas tissue remodeling evident lung compliance significantly reduced bleomycin cthrc effect animals data suggest cthrc reduces fibrotic tissue formation bleomycin induced lung fibrosis effect potent enough limit decline lung function conclude cthrc plays protective role limiting collagen deposition could form basis novel therapy pulmonary fibrosis
article discusses related art network security management proposed design multi level network security management system based middleware ice technology design single level system design related species module overall framework implementation given based communication module ice technology detailed design done lan wan communication various modules realization various kinds levels network security devices associated host centralized monitor centralized configuration variety security related information timely manner log collection management network species real time view network security status dynamically adjusting network security policy comprehensive network security audit information effectively improve overall security network security management
many applied problems arising agricultural monitoring food security require reliable crop maps national global scale large scale crop mapping requires processing andmanagement large amount heterogeneous satellite imagery acquired various sensors consequently leads big data problem main objective study explore efficiency using google earth engine gee platform classifying multi temporal satellite imagery potential apply platform larger scale country level multiple sensors landsat sentinel particular multiple state art classifiers available gee platformare compared produce high resolution crop classification map large territory similar cropland though study involve large volumes data address efficiency gee platform effectively execute complex workflows satellite data processing required large scale applications crop mapping study discusses strengths weaknesses classifiers assesses accuracies achieved different classifiers ukrainian landscape compares benchmark classifier using neural network approach developed previous studies study carried joint experiment crop assessment monitoring jecam test site ukraine covering kyiv region north ukraine found gee provides good performance terms enabling access remote sensing products cloud platform providing pre processing however terms classification accuracy neural network based approach outperformed support vector machine svm decision tree random forest classifiers available gee
new three dimensional based metal organic framework formula bpy dihydroxypyridine carboxylate bpy bipyridine synthesized hydrothermal condition ray diffraction analyse reveals compound exhibits unique two fold interpenetrated coordination framework connected fsx network topology ligand adopts bridging fashion addition experimental results anti inflammatory activity showed compared organic ligands bpy title compound exerted rather potent activity
simple method aid design digital compensators power switching converter presented simple equations feasible designs determined depending characteristics converter sampling frequency time delay restrictions allows carry sensitivity analysis different parameters obtaining insightful assessment influence system performance
tissue systems distributed parallel computing models inspired structure tissue way communicating substances two cells cell environment work consider variant tissue systems called tissue systems promoters application rules regulated promoters computational power systems investigated specifically proved systems using antiport rules length using symport rules length able compute finite sets non negative integers however systems one cell using antiport rules length symport rules length using symport rules length turing universal moreover uniform solution sat problem provided tissue systems promoters cell division using antiport rules length elsevier rights reserved
paper discusses design process permanent magnet free machine based actuators working elevated temperature environments high dynamic applications demands given application respect maximum volume torque speed performance thermal limits insulation materials limit maximal loss may occur considered starting geometry semianalytic modeling approaches used within optimization algorithm obtain machine design suitable application
introduction salusins multifunctional endogenous peptides shown human rat tissues serum salusin alpha level decreased coronary artery disease lack salusin alpha enhances coronary atherosclerosis hypothyroidism chronic inflammatory disease high risk developing cardiovascular disease aimed search relationship overt hypothyroidism subclinical hypothyroidism salusin alpha inflammatory markers also effect thyroxine treatment findings material methods patients overt hypothyroidism taking thyroxine treatment patients subclinical hypothyroidism without treatment healthy patients control group included study serum salusin alpha tnf alpha scrp glucose insulin lipid levels tested groups results evaluated spss statistical analysis method results hdl scrp salusin mean values statistically significantly different groups hdl level statistically significantly higher control group compared treatment group scrp level higher salusin level lower treatment non treatment hypothyroidism groups compared control group treatment non treatment hypothyroidism groups compared statistically significant difference salusin hdl level high insulin level low statistically significant treatment group conclusions salusin alpha shown protective coronary artery disease hypertension found significantly low hypothyroidism thus marker increases cardiovascular disease risk specific patient group
comparison sources water supply rainwater harvesting rwh typical advantages cheaper easier operate maintain study aimed assessing hydrologic rainwater harvesting potential rural schools south africa obtaining rwh storage capacity level supply reliability relationships representative schools thirty two schools located three rural areas varied rainfall characteristics selected analysis school daily time step behaviour analysis rainwater harvesting system specified storage carried period years rainfall data available number days school daily water demand met year obtained using weibull plotting position formula expected number days demand met per year obtained reliability two summer rainfall regions large proportion rain falls school holidays expected number days supply per year improved storage capacity winter rainfall region rainfall periods school learning times incidence tank volume obtained similar supply levels larger capacities reliability supply levels different schools summer rainfall area mean annual precipitation map year ranged days per year summer rainfall region lower map gave supply levels ranging days per year winter rainfall area map obtained supply levels ranging days reliability
objective cross sectional study define normal sex age dependent values intra articular bone mass microstructures metacarpal heads healthy individuals high resolution peripheral quantitative computed tomography pqct test effect rheumatoid arthritis parameters human cadaveric metacarpal heads used exactly define intra articular bone healthy individuals different sex age categories patients similar age sex distribution received pqct scans second metacarpal head radius total cortical trabecular bone densities well microstructural parameters compared different ages sexes healthy individuals metacarpal heads radius healthy individuals patients cadaveric study allowed exact definition intra articular intracapsular bone margins data applied measuring intra articular radial bone parameters women men healthy individuals patients correlations intra articular radial bone parameters good contrast radial bone intra articular bone remained stable age years decreased significantly women thereafter loss cortical trabecular bone similarly patients showed significant loss intra articular total trabecular cortical bone compared sex age adjusted controls standard sex age dependent values physiological intra articular bone defined postmenopausal state led significant decrease intra articular bone american society bone mineral research
article proposes employment proportional valve calculate amount oxygen air given patient accordance amount fio set control menu ventilation device actualize stepper motor controlled proportional valve used two counts valves employed order control gases bar pressure came oxygen medical air tanks oxygen medical air manometers alongside pressure regulators utilized perform task fuzzy logic based controller calculates rate proportional valves opened closed fio calculation fluidity pressure air given ventilation device tested flow meter oxygen level tested using electronic lung model obtained results study revealed stepper motor controlled proportional valve could safely used ventilation devices article indicated fluidity pressure control could carried two counts proportional valve could done many solenoid valves reduces cost ventilator electrical power consumed ventilator dimension ventilator
introduction data eeg commonly used psychiatrists plan treatment medication however eeg abnormalities isolated epileptiform discharges found prevalent psychiatric patients particularly diagnosed autism spectrum disorder asd medications prescribed asd lower seizure threshold increase side effects therefore may prudent order eeg asd cases especially categorized refractory methods data set obtained multidisciplinary practice treats wide variety neuroatypical children adolescent refractory patients study investigated nonepileptic subjects diagnosed asd aged years visual inspection eeg performed search paroxysmal focal lateralizing patterns results subjects eeg data identified isolated epileptiform discharges analysis found significant difference genders among three age groups findings indicated high prevalence isolated epileptiform discharges among individuals asd conclusions results find compared healthy population large number patients asd isolated epileptiform discharges despite never seizure findings support use eeg children adolescents young adults asd regardless gender age particularly true exhibit aggressive behaviors failed previous medication attempts stimulants antidepressants antipsychotics
correlation process gnss receiver tracking module computationally prohibitive executed central processing unit cpu using single instruction single data algorithms efficient replacement cpu graphics processing unit gpu gpu composed massive parallel processors high floating point performance memory bandwidth used accelerate burdensome correlation process gnss software receivers propose novel gpu based correlator architecture gnss software receivers independent gpu device number processing channels signal type correlation time proposed architecture implemented optimized using cuda parallel computing platform programming model gpus focus following aspects design time complexity analysis proposed gpu based correlator algorithm tests verify correctness optimization implementation performance evaluation optimized gpu based correlator moreover introduce new cuda features applied gpu based correlator
utero exposure rats nicotine nic provides useful animal model studying impact smoking pregnancy human offspring certain sequelae prenatal nic exposure suggest impact development midbrain dopamine system receives robust cholinergic innervation mesopontine tegmentum therefore investigated whether prenatal nic induced structural changes cells synapses within midbrain persisted adulthood osmotic minipumps delivering either sodium bitartrate vehicle veh nic bitartrate day implanted nine timed pregnant dams birth rat pups culled litters six males litters cross fostered plasma levels nic cotinine killed pups provided evidence nic exposure utero pups separated dams weaning showed trend toward reduced locomotor activity time point tested adulthood adult rats killed anatomical studies estimates brain size volume vary nic treatment midbrain sections stained nissl immunoperoxidase tyrosine hydroxylase analyzed using unbiased stereology revealed changes volume cell number substantia nigra compacta ventral tegmental area result nic exposure within ventral tegmental area electron microscopic physical disector analysis showed significant differences number axon terminals number asymmetric putative excitatory symmetric putative inhibitory synapses although infrequent estimate unbiased stereology obvious difference proportion cholinergic axons noted nic versus veh treated animals data suggest activation nicotinic receptors prenatal development induces significant modifications structure cells ventral midbrain assessed adulthood
oxidative stress confirmed contribution pathogenesis pathophysiology many neurological disorders alzheimer disease parkinson disease caffeoylquinic acids cqas considered anti oxidative stress ability previous study structure activity relationships sars cqas neuroprotective effects still unclear present study primarily expound sars cqas counteracting induced injury syy cells found cqas represented protection syy cells induced injury varying degrees malonyl groups could obviously increase anti oxidative stress ability cqas intensive studies dicaffeoyl malic acid methyl ester quinic acid mdcqa indicated mechanisms could potentially involve activation endogenous antioxidant enzymes regulation phosphorylation mapks akt conclusion mdcqa could serve neuroprotective agent potential attenuate oxidative stress
paper new formulation coupled circuit electromagnetic simulation presented formulation employs full wave integral equations model behavior two three dimensional structures using modified nodal analysis model circuit interactions coupling scheme based charge current continuity potential matching realized generalization kirchoff voltage current laws ensures circuit interactions formulated seamless system rigorous port models structures obtained using approach discussed herein shown coupling paradigm reveal additional details circuit interactions provide path analysis based design iteration
evaluate changes dynamic pupillometry patients idiopathic overactive bladder oab study included female patients idiopathic oab healthy female volunteers control group demographic clinical data recorded dynamic pupillometric parameters measured commercially available unit monpack one metrovision france baseline day treatment antimuscarinic treatment drug agent solifenacin daily initial minimum maximum mean pupil diameters latency duration contraction dilatation pupil amplitude contraction dilatation velocity automatically measured compared groups significant differences two groups respect age body mass index respectively measurements initial minimum mean pupil diameters significantly lower patients oab compared healthy controls respectively oab patients significantly longer latency pupil dilatation latency pupil contraction shorter duration pupil contraction control group respectively antimuscarinic treatment latency pupil contraction latency pupil dilatation duration pupil contraction shortened significantly pupil dilatation velocity increased significantly treatment dynamic pupillometric findings study imply impaired autonomic dysfunction mostly increased parasympathetic action oab patients modulatory effects antimuscarinic treatment
experimental study conducted investigate impact violent computer games state hostility state anxiety arousal participants undergraduate students aged years old experimental sessions participants filled self report measures concerning video game habits also pre tested aggressiveness trait anxiety physiological responses heart rate skin conductance measured experiment playing information state hostility state anxiety collected results showed participants played violent game reported significantly higher state hostility support assumption aggressive personality moderates effect playing violent game state hostility
last decade keyword search relational databases extensively studied promises allow users lacking knowledge structured query languages unaware database schema query database intuitive way existing works keyword search databases proposed many approaches gain remarkable results however approaches designed centralized setting keyword search processed single server reality scale databases increases sharply centralized methods hardly handle keyword queries large databases moreover processing keyword search relational databases time consuming task efficiency existing centralized approaches degrade notably single server provide enough computation power keyword search large databases address challenges propose distributed keyword search dks approach mapreduce approach well deployed cluster servers deal keyword search large databases parallel way
bias crime literature focuses adults despite fact youth account large proportion prejudice motivated violence county commission human relations data bias crimes used examine similarities differences adult youth suspects bias motivated crimes findings showed youth victims racial bias crimes times likely targeted youth suspects five times likely commit property offenses public places nearly three times likely resident places location bias crime youth suspects female perpetrators racial bias crimes two times likely youths implications findings discussed
memristor claimed passive fourth fundamental circuit element four decades later physical realization presents memristor behavior resulted significant interest memristor continuing increase growing rate memristor provide new possibilities analog circuit design thanks properties mimicked older passive circuit elements since practically available memristor exist market yet obtaining practical implementation behaves like memristor important point view real world circuit design paper ultra low voltage ultra low power dtmos based memristor design presented ultra low voltage ultra low power operational amplifier ultra low voltage ultra low power multiplier also designed use implementation memristor design composed two type active blocks using cmos process technology symmetric supply voltages memristor used second order sallen key band pass filter topology designed memristor based sallen key band pass filter used real electroencephalogram data processing simulation results show design adjustable memristor memristance memductance provides tunable filter parameters without significant distortion appropriate parameter set even ultra low power levels low frequencies
objectives study aims investigate efficacy acupuncture preventing migraine attacks patients methods december june total patients diagnosis migraine neurology clinic randomized two groups venlafaxine administered three months one group drug therapy group males females mean age years range years group treated acupuncture acupuncture group males females mean age years range years control group consisted total healthy individuals males females mean age years range years blood serotonin levels assessed treatment along visual analog scale vas migraine disability assessment midas groups results statistically significant difference mean analgesic use treatment vas midas scores acupuncture drug therapy groups number duration attacks found significantly lower groups compared pre treatment values serotonin levels acupuncture drug therapy groups significantly higher compared pre treatment values serotonin levels found significantly lower healthy individuals compared study groups conclusion based study findings acupuncture may effective option migraine prophylaxis
rainwater harvesting rwh provides various social environmental economic benefits important first consider individual preferences willingness use harvested water different purposes order encourage community use rwh establish strategies allow introduction alternative water supply additionally foster water management sustainable practices paper presents willingness individuals use rwh three localities guanajuato romita silao state guanajuato mexico evaluated acceptance using collected rainwater found results questionnaires directly applied owners dwelling users urban areas localities studied aspects related rwh included study characteristics population dwellings
principal aim study establish whether metabolic monitoring program implemented second generation antipsychotic medications sgas associated reduction prevalence metabolic syndrome adult inmates treated antipsychotic medications new jersey department corrections average prevalence metabolic syndrome prescribed sgas decreased years metabolic monitoring years monitoring number patients prescribed antipsychotic medication decreased net years study conclude metabolic monitoring one several administrative interventions study period reduced unnecessary exposure inmates risks antipsychotic medications
parental parent infant attachment parenting alliance defined two important components psychoaffective adjustment parental role study aimed build predictive model parental attachment parenting alliance mothers fathers using partial least squares structural equation modeling specifically interested assessing adult romantic attachment marital quality psychological distress influenced parental attachment parent infant parenting alliance forty heterosexual couples completed questionnaires third trimester pregnancy months childbirth results showed adult romantic attachment marital quality psychological distress important antenatal determinants parental attachment parenting alliance although behaved differently mothers fathers hence different predictive models therefore proposed mothers fathers mothers attachment child influenced internal factors adult attachment dimensions fathers also depended mothers antenatal attachment child marital quality concerning parenting alliance mothers fathers depended partner variables antenatal variables important occurs transition parenthood terms parenting adjustment act differently mothers fathers thus important assess psychological functioning mothers fathers
age estimation face images important yet difficult task computer vision main difficulty lies design aging features remain discriminative spite large facial appearance variations meanwhile due difficulty collecting labeling datasets contain sufficient samples possible ages age distributions benchmark datasets often imbalanced makes problem challenge work try solve difficulties means mainstream deep learning techniques specifically use convolutional neural network learn discriminative aging features raw face images without handcrafting combat sample imbalance problem propose novel cumulative hidden layer supervised point wise cumulative signal cumulative hidden layer model learnt indirectly using faces neighbouring ages thus alleviate sample imbalance problem order learn effective aging features propose comparative ranking layer supervised pair wise comparative signal comparative ranking layer facilitates aging feature learning improves performance main age estimation task addition since one face included many different training pairs make full use limited training data noted two novel layers differentiable model end end trainable extensive experiments two largest benchmark datasets show deep age estimation model gains notable advantage accuracy compared existing methods
age related hearing loss arhl postulated affect dementia study aims investigate relationship arhl prevalence year incidence dementia taiwan national health insurance research database nhird selected patients diagnosed arhl nhird comparison cohort comprising patients without arhl frequency matched age sex morbidities occurrence dementia evaluated cohorts arhl cohort consisted patients arhl control cohort consisted frequency matched patients without arhl incidence dementia hazard ratio confidence interval higher among arhl patients cox models showed female well morbidities including chronic liver disease cirrhosis rheumatoid arthritis hypertension diabetes mellitus stroke head injury chronic kidney disease coronary artery disease alcohol abuse dependence tobacco abuse dependence independent risk factors dementia arhl patients found arhl may one early characteristics dementia patients hearing loss higher risk subsequent dementia clinicians sensitive dementia symptoms within first years following arhl diagnosis clinical studies relationship dementia arhl may necessary
wireless sensor networks domain one used standards ieee standard made available many low power operating systems tinyos contiki crucial implementation compliant specifications standard case contiki provided version main medium access algorithm unslotted carrier sensing multiple access collision avoidance csma presents many flaws paper discuss implementation provided csma algorithm point parts respect standard specifications also propose implement compliant version algorithm show simulation correctness implementation
widespread lung cancer screening low dose computed tomography urgently needed europe identify lung cancers early reduce lung cancer deaths effective method identifying high risk individuals recruiting screening determined present pilot study investigated direct telephoning families way identifying high risk individuals recruiting screening smoking cessation program avoided selection bias voluntary screening families province milan italy contacted telephone homes asked family members years heavy smokers pack years persons meeting criteria contacted asked participate program agreed given appointment undergo screening receive smoking cessation counseling among contacted families involving persons eligible ldct screening participated program cost recruitment strategy pilot study around euro per screened subject obtained useful information proportion general population eligible lung cancer screening proportion responded however cost home telephone calling probably high practicable method recruiting high risk persons screening alternative recruitment methods possibly involving family physicians practitioners need investigated elsevier ireland ltd rights reserved
traditionally treatments depression primarily focused reducing patients symptoms deficits less concerned building positive resources study aims compare efficacy manualized protocol empirically validated positive psychology interventions ppi cognitive behavioral therapy cbt protocol controlled clinical trial included adult women dsm diagnosis major depression dysthymia participants blindly allocated session ppi cbt group therapy condition intention treat analysis showed interventions effective reducing clinical symptoms increasing well significant differences groups either main outcomes severity depressive symptoms clinical diagnosis secondary outcomes positive negative affect satisfaction life even within severely depressed participants differences ppi cbt emerged clinical studies confirm results would widen treatment choice patients professionals
type positive allosteric modulators pams alpha nicotinic receptor enhance cholinergic activation preserving spatiotemporal features synaptic transmission receptor characteristic rapid desensitization kinetics alpha nicotinic receptor agonists shown promise improving cognition schizophrenia longer term trials disappointing therefore type pam avl evaluated safety preliminary evidence neurocognitive effect healthy human subjects single dose oral administration ascending doses conducted double blind placebo controlled phase trial non smokers trial found indication positive non significant effects neurocognition two doses produced overlapping peak levels also evidence effects inhibition auditory evoked potential repeated stimuli biomarker responds alpha nicotinic receptor activation pharmacokinetic characteristics consistent subjects safety concerns effects safety profile also assessed cohort smokers concurrent nicotine administration alter either effects safety trial demonstrates type pam safely administered humans potential positive neurocognitive effects central nervous system cns disorders
genira gender rheumatoid arthritis comprehensive project aimed studying gender differences patients differences impact patient outcomes reporting data seventy patients gender cross sectionally evaluated following preestablished protocol univariate multivariate analyses focused different gender associated comorbidity profiles impact quality life disability patients assessed modified health assessment questionnaire haq respectively groups comparable regarding main demographic clinical features different comorbidity profiles found genders higher frequencies diabetes mellitus peptic ulcer ischemic heart disease smoking chronic obstructive pulmonary disease among men depression osteoporosis among women haq lower women men sub scales mental health general health physical functioning physical summary component psc multivariate analysis indicated independent association depression osteoporosis rather gender haq psc depression women present significantly worse disability qol outcomes men differences explained female gender associated comorbidities depression osteoporosis rather gender per
paper presents fast accurate approach dynamic electrothermal analysis photovoltaic plants cell level discretization circuit model developed elementary cell equivalent electrical network automatically built preprocessing stage account power temperature feedback plant analysis represented electrical macrocircuit solved low cpu memory requirements without convergence issues using spice like simulator proposed strategy successfully exploited diagnostic purposes
association gluten related disorders psychiatric diseases firmly demonstrated non celiac gluten sensitivity ncgs syndrome diagnosed patients responsive gluten free dict ruling celiac disease wheat allergy pathogenesis neuro psychiatric disorders ncgs unclear association gluten schizophrenia described tier first time bender dicke noted gluten free diet improved mood celiac patients goldberg study celiac patients tbund showed minor affective disorders bipolar disorder patients show increase blood anti gliadin deamidated antibodies lgg effect diet nutrition autistic spectrum disorders investigated last two decades particularly focusing symptoms hyperactivity attention toxoplasma gondit neurotropic pathogens influenzavints coronavints may associated mood disorders probably secondary increased intestinal permeability abnormalities host microbiota interactions gut microbiota composition associated central nervous system disorders autism anxiety depression integrity intestinal microbiota may considered potential therapeutic goal treat conditions
cave automatic virtual environment cave fully immersive virtual reality system cave systems widely used many applications architectural industrial design medical training surgery plan museums education however one limitation current cave systems separated real world user cave able sense real world around paper propose vconnect architecture aims establish real time bidirectional information exchange virtual world real world utilizing advanced technologies cloud computing mobile communications wireless sensor networks computer vision specifically address three technical challenges proposed vconnect architecture first propose optimal allocation scheme wireless sensor networks ensure data streams captured sensors delivered cloud servers reliable prompt way second optimize allocation cloud resources ensure data streams sent clients processed promptly cloud servers minimal resource cost third propose use marker based finger interactions user cave manipulate information natural intuitive way fourth implemented vhealth prototype cave based real time health monitoring system validate proposed vconnect architecture demonstrated vhealth prototype user cave visualize manipulate real time physiological data patient monitored interact patient
stress encoding affects memory processes typically enhancing preserving memory emotional information effects interesting implications eyewitness accounts real world contexts typically involve encoding aversive event stressful conditions followed potential exposure misinformation present study investigated memory negative event encoded stress subsequent misinformation endorsement healthy young adults participated groups design three experimental sessions conducted apart session one consisted psychosocial stress induction control task followed incidental encoding negative slideshow session two participants asked questions slideshow random subgroup exposed misinformation memory slideshow tested third session assessment memory accuracy across stress stress groups revealed stress induced prior encoding led significantly better memory slideshow overall classic misinformation effect also observed participants exposed misinformation significantly likely endorse false information memory testing stress group however memory accuracy misinformation effects moderated arousal experienced encoding negative event misinformed stress group participants reported negative slideshow elicited high arousal encoding less likely endorse misinformation aversive phase story furthermore individuals showed better memory components aversive slideshow phase directly misinformed results current study provide evidence stress high subjective arousal elicited negative event act concomitantly encoding enhance emotional memory aversive aspects event well remembered subsequently resistant misinformation effects authors published elsevier inc rights reserved
idiopathic pulmonary fibrosis ipf chronic progressive usually lethal disease associated aging however molecular mechanisms aging process contribute pathogenesis ipf elucidated ipf characterized abundant foci highly active fibroblasts myofibroblasts resistant apoptosis remarkably role aging autophagy activity lung fibroblasts relationship apoptosis adaptive responses evaluated previously disease present study analyzed dynamics autophagy primary lung fibroblasts ipf compared young age matched normal lung fibroblasts results showed aging contributes lower induction autophagy basal conditions starvation mediated mtor pathway activation treatment rapamycin target pik akt mtor signaling pathway modified starvation induced autophagy apoptosis ipf fibroblasts interestingly found persistent activation pathway starvation contributes apoptosis resistance ipf fibroblasts findings indicate aging affects adaptive responses stress decreasing autophagy activation mtorc lung fibroblasts activation pathway also contributes resistance cell death ipf lung fibroblasts
objective self modeling curve resolution smcr methods decompose second order bilinear data matrix range chemically meaningful matrices without knowledge chemical physical model describing considered system addition smcr methods efficient approaches deeply investigate data structures finding one solutions possible ones multi set data analysis powerful tool decrease range feasible solutions absence appropriate conditions unique resolution using smcr methods investigated impact multi set data analysis accuracy soft modeling results interestingly feasible regions individual simultaneous analysis compared common abstract space demonstrated global analysis result reduction rotational ambiguity soft modeling analysis moreover systematic study different factors considered order discover advantages limitations multi set data analysis lead proper design accurate results elsevier rights reserved
several challenges field ontology matching outlined recent research selection appropriate similarity measures well configuration tuning combination known fundamental issues community deal verifying semantic coherence discovered alignment also known crucial task challenging issues basic matching techniques combination approach aimed provide improvement basic matcher level also level framework matching large scale ontologies currently one challenging issues ontology matching field main reason large ontologies highly heterogeneous terminological conceptual levels furthermore matching large ontologies entails exploring large searching space discover correspondences may also require huge amount main memory maintain temporary results computational step factors strongly impact effectiveness efficiency ontology matching tool overcome issues developed disk based ontology matching approach underlying idea approach complexity therefore cost matching algorithms reduced thanks indexing data structures avoiding exhaustive pair wise comparisons indeed extensively used indexing techniques many places example defined bitmap encoding structural information ontology indexing structure exploited accelerating similarity propagation moreover approach uses disk based mechanism store temporary data allows perform ontology matching task simple laptop instead powerful server paper describe yam ontology matching tool aimed solving issues evaluated efficiency yam various oaei oaei tracks yam one best ontology matching systems terms measure notably current version yam passed scalability large scale ontology matching tests obtained high matching quality results elsevier rights reserved
introduction clinical characteristics icatibant treatment outcomes patients hereditary angioedema normal inhibitor hae inh limited methods retrospectively analyzed data french hae patients enrolled icatibant outcome survey registry july september compare disease characteristics effectiveness safety acute icatibant treated angioedema attacks patients hae inh hae inh deficiency type dysfunction type results one center grenoble contributed patients hae inh family history hae centers across france contributed patients hae type seven patients hae type patients hae inh compared hae type respectively likely female older median age disease onset years years greater rate abdominal laryngeal attacks icatibant effective groups though median time resolution attack significantly longer hae inh group attacks versus hae type group attacks icatibant self administered attacks patients hae inh patients hae type serious adverse side effects related icatibant reported conclusions data help define disease characteristics hae inh french population extend limited data reporting safe effective use icatibant acute treatment angioedema french patients diagnosed hae inh
agricultural environmental pollution china deteriorating recent years chemical pollution issues become prominent favorable sustainable development china economy paper reports current status development utilization efficiency pesticides chemical fertilizer plastic film total power agricultural machinery moreover comparative analysis input chemical polluting factors agricultural cultivation china horizontal vertical perspectives presented data envelopment analysis model used evaluate comprehensively utilization efficiency factor results indicate inputs chemical pollutants agricultural cultivation china differed greatly among regions inputs increased annually usage amounts pesticides chemical fertilizer plastic film chemical pollutants exhibited lower growth rate total power consumed agricultural machinery utilization efficiencies chemical pollutants generally low regions non effective efficiency decreasing returns scale
proverbs folkloric products important references cultural codes behavioral patterns suppositions related various issues imagination society products may relate countless topics notions social life approaches education social gender issues otherization tendencies paradigms governance applications authority particular topic among phenomenon communication communication acts therefore proverbs scanned clues explaining communication phenomena socially approved proposed communication acts starting presupposition essential aim study communicational phenomena turkish proverbs explore explicit hidden messaging related communicational acts sense study significant contribution formation map communicational semantics turkish society respect browsed proverbs idioms dictionary turkish language association certain words conducted thematic analysis proverbs found relation found many proverbs exerted importance verbal communication relation attributes utterance implications many proverbs exhibited rhetoric affirmed nonverbal communication acts like silence listening reticence hand proverbs visual communication featured messages proposed people judged appearance dressing
study suspensions oblate rigid particles viscous fluid different values particle volume fractions direct numerical simulations performed using direct forcing immersed boundary method account dispersed phase combined soft sphere collision model lubrication corrections short range particle particle particle wall interactions respect single phase flow show flows laden oblate spheroids drag reduced turbulent fluctuations attenuated particular turbulence activity decreases lower values obtained accounting effective suspension viscosity explain observed drag reduction consider particle dynamics interactions particles turbulent velocity field show particle wall layer previously observed found responsible increased dissipation suspensions spheres disappears case oblate particles rotate significantly slower spheres near wall tend stay major axes parallel wall leads decrease reynolds stresses turbulence production overall drag reduction
olive tree olea europaea affected colletotrichum acutatum causing loss yield quality final products whilst incidence fungal infection depends several factors including cultivar susceptibility thus effect acutatum infection cultivars displaying different susceptibilities fungal disease galega vulgar susceptible cobrancosa moderately susceptible picual tolerant assessed spectrophotometric methods hplc ftir spectra cuticles concomitantly registered resorting atr accessory support multivariate analysis spectra allowed discriminate olives distinct infection times besides retrieving evidences concerning different susceptibility cultivar observations reinforced spectrophotometric chromatographic methods furthermore assessment phenolic profile evidenced individual compounds distinct cultivars variations response fungal infection distinct olive cultivars inoculated colletotrichum acutatum resistant olive tree cultivars display highest content phenolics ftir atr based analyses allow monitor response olive fruits acutatum
objective vasectomies safe effective family planning options however factors associated utilization poorly understood examine differences vasectomy rates according socioeconomic status education family composition materials methods retrospective surgical records reviewed vasectomies completed january september china medical university hospital taichung taiwan men received vasectomy questioned person telephone interview questionnaires consisting demographic socioeconomic reproductive characteristics analyzed assess vasectomy associations relationships seasonal sterilization numbers prosperity analyzed results consequently married male taiwanese patients studied one hundred sixty two patients answered questionnaire men chose vasectomies relatively well educated men boychild bearing men belonged families higher socioeconomic standing half men vasectomy recipients underwent procedure within year birth last child seasonal vasectomy number also showed negative correlation seasonal taiwan monitoring indicators reflecting prosperity lev conclusion accounting reproductive history partner demographic characteristics education status already male children belonging middle class factors associated vasectomy acquisition research needed identify causes differences additionally economic fluctuations appear related sterilization decisions within families copyright taiwan urological association published elsevier taiwan llc
preserve structure integrity graphene enhance dispersion compatibility matrix attracts attention researchers graphene polymer nanocomposite field paper methacryloxyethyltrimethyl ammonium chloride dmc kind ionic liquids first used non covalently functionalize graphene process graphene oxide reduction modified graphene dmc rgo incorporated poly vinyl alcohol pva matrix solution casting technique fabricate dmc rgo pva composites structure properties obtained dmc rgo investigated ray diffraction analysis xrd ray photoelectron spectroscopy xps transmission electron microscope tem atomic force microscopy afm raman test results showed graphene could successfully modified dmc ionic interaction structure integrity graphene could reserved non covalently approach furthermore reduction process hydroxyl groups introduced dmc rgo virtue intrinsic properties dmc rgo fabricated dmc rgo pva composites exhibit considerable enhancements mechanical properties remarkable improvements thermal stability well enhancement electrical conductivity low dmc rgo loading simple modification approach gives new opportunity improve performances graphene polymer composites wiley periodicals inc appl polym sci
growing body literature marks feminist ethics care within framework understand transitions primary secondary school education challenging care less especially disabled children exploring narratives parents professionals investigate transitions self identity meaningful transition depends care full spaces pupils inhabit education narratives context privileging academic attainment culture testing examinations parents professionals well children also surveyed care full education processes marginalisation remain impacting disabled children transition secondary school healthy identity construction moreover educational challenges addressed life chances increasingly limited interdependent caring work enables engagement meaningful education positive identity formation school home care full spaces key process
study done evaluate effects stress management program smp stress problem solving skills quality life hospitalized patients schizophrenia methods mixed method design used combination repeated measure design non equivalent control group qualitative data collection participants patients schizophrenia admitted three psychiatric hospitals experimental group received smp twice week total weeks results study results revealed smp effective stress problem solving ability quality life hospitalized persons schizophrenia conclusion results suggest smp effective strategy reduce patients hospitalization stress improve problem solving skills quality life therefore recommended mental health nurses use stress management program clinical practice assist adaptation hospitalization persons schizophrenia
recalling event people usually retrieve main facts reduced proportion specific details objective experiment study effects conceptually perceptually driven encoding recall conceptual perceptual information event materials selected experiment two movie trailers enhance encoding instructions watching first trailer participants answered conceptual perceptual questions event control group answered general knowledge questions watching second trailer participants completed closed ended recall task consisting conceptual perceptual items conceptual information better recalled perceptual details participants made perceptual conceptual commission errors conceptually driven processing enhanced recall conceptual information perceptually driven processing improve recall descriptive details also damaged standard conceptual perceptual recall relationship
modern scientific experiments generate vast volumes data hard keep track consequently scientists find difficult reuse share data sets address problem developing schema independent data cataloging framework efficient management scientific data proposed solution consists agent automatically identifies new data products extract metadata well server indexes metadata using nosql database provides rest api querying sharing reusing data sets novelty solution lies pluggable metadata extraction logic extensible data product generation monitors use nosql database ability dynamically add new metadata fields use apache solr backend database enables proposed solution index search data products much fatser solution based relational databases example apache solr based implementation resolve full text sub string prefix suffix queries faster mysql based implementation
data structures integral topic computer science software engineering degree identified core tier topic acm ieee computer science curricula underlying concepts inherently abstract making especially difficult understand novice programmers paper proposes cognitively challenging technique help students understand thought process learning outcomes fundamental data structure units aim achieve development thought process using technique term visual kinesthetic pseudocode overarching goal helping students code without coding yet providing necessary scaffold guide implementing data structures real code implemented form interactiveds app students teachers guide learning fundamental data structure concepts evaluations demonstrate students strongly credited interactiveds aiding understanding concepts confidence applying data structure concepts practice study also step forward revealing potential threshold concepts pertaining data structure modules wiley periodicals inc
endocrine disrupting chemicals edcs widespread environmental contaminants affect many neuroendocrine functions brain particularly vulnerable edcs critical periods gestational development gonadal hormones exert organizational effects sexually dimorphic behaviors later life peripubertal development also time continued neural sensitivity organizing effects hormones yet little known edc actions times sought determine effects prenatal juvenile exposures class edcs polychlorinated biphenyls pcbs human relevant dosages development physiology social anxiety related behaviors later life consequences second juvenile hit following prenatal treatment exposed male female sprague dawley rats pcbs aroclor day injection vehicle prenatal development embryonic days juvenile development postnatal days exposures differential effects behaviors sex age dependent ways prenatal exposure effects juvenile juvenile exposure often modified unmasked effects first hit additionally females exhibited altered social anxiety behavior adolescence males displayed small significant changes sociosexual preferences adulthood thus brain continues sensitive organizing effects edcs juvenile development humans exposed edcs throughout multiple periods life findings implications understanding edc effects physiology behavior elsevier inc rights reserved
objectives identify describe assess evidence regarding effects diabetes conversation map program educational tool engages patients diabetes group discussions diabetes related topics range patient outcomes study design systematic review data sources five databases including pubmed cinahl scopus embase cochrane collaboration utilized identify studies evaluated conversation map program additionally reference lists identified studies manually reviewed review methods studies evaluated conversation map program since included non english languages non journal papers studies included description program excluded quality assessment relevant studies performed outcomes grouped objective hbac levels subjective self efficacy health behaviors medication adherence results studies originally identified studies included final sample overall methodological quality studies intermediate score almost studies examined objective health measures indicating non significant differences conversation map intervention control groups conflicting results found regarding influence program hbac majority studies reported significant change blood pressure mixed results found regarding health indicators twelve studies examined subjective measures assessed effects health behaviors mostly reporting non significant positive findings conclusions review shows although diabetes conversation map program holds potential improve patient behaviors outcomes current research program provides limited support relationship positive patient outcomes larger sophisticated studies needed order determine potential influence conversation map long term health outcomes elsevier ltd rights reserved
rationale isolated dismal transverse aortic arch kinking adults rare recommended therapy present percutaneous stent implantation may effective method correct could considered patient concerns report year old woman suffered recurrent migraine refractory hypertension significant systolic blood pressure difference upper limbs diagnoses woman diagnosed isolated dismal transverse aortic arch kinking refractory hypertension interventions percutaneous stent implantation performed due kinking nature diseased transverse aortic arch first covered stent moved forward proximal transverse aortic arch deploying without left common carotid artery occlusion second stent placed cover residual kinked part dismal transverse arch outcomes angiography post procedural computed tomography angiography revealed fully corrected diseased segment month follow procedure patient free symptoms normal blood pressure antihypertensive treatment lessons case indicates transverse aortic arch kinking isolation well treated percutaneous stent implantation adult patients unlike pure aortic coarctation elongation bucking give rise occurrence rate stent sliding migration sometimes second stent needed
named data networking ndn architecture packets carry data names rather source destination addresses realize paradigm ndn router maintains three data structures pit fib forwarding plane designing quick enough forwarding plane high capacity major challenge within overall ndn research area paper present novel implementation fib called mafib evaluations indicate excellent data structure efficient lookup algorithm mafib effectively reduce memory cost accelerate lookup process outstanding performance probability false positive also makes mafib meet current network requirements
paper proposes neural network based adaptive constrained control scheme solid oxide fuel cell sofc first radial basis function rbf neural network designed identification sofc dynamic model jacobian information obtained identified rbf model back propagation neural network based pid controller designed tune parameters neural network strong self learning adaptive capabilities time order solve control input saturation fuel utilization problems sofc dynamic anti windup compensator proposed accommodating reference moreover paper theoretically proves stability proposed method based lyapunov stability analysis finally simulation results sofc provided demonstrate effectiveness proposed constrained control approach elsevier rights reserved
much attention paid burden shifting emissions developed regions developing regions trade however less discussed trade also acts mechanism enabling wealthy consumers shift water quantity quality stress trading partners study investigate shanghai largest megacity china draws water resources china outsources pollution virtual quantity quality water flows associated trade results show shanghai consumption goods services led billion freshwater consumption thousand tons cod thousand tons discharged wastewater freshwater consumption cod occurred chinese provinces provide goods services shanghai thirteen provinces severe extreme water quantity stress accounted net virtual water import shanghai provinces experiencing water quality stress endured net cod outsourcing net outsourcing shanghai accordance three redlines recently put forward chinese central government control water pollution cap total water use provinces suggest shanghai share responsibility reducing water quantity quality stress trading partners taking measures provincial industrial consumer levels meantime shanghai needs enhance demand side management promoting low water intensity consumption
maritime industry use pod propulsion system strengthened cruise ships also type vessels several studies performed order investigate power quality issues system failures pods used paper systematic approach developed order investigate pod propulsion electrical point view load torque applied propeller electric machine studied modelled dynamic load changes simulated presented
background global doctors choice transnational network physician advocates reproductive health rights began exploring phenomenon conscience based refusal reproductive healthcare result increasing reports harms worldwide present white paper examines prevalence impact refusal reviews policy efforts balance individual conscience autonomy reproductive decision making safeguards health professional medical integrity objectives search strategy white paper draws medical public health legal ethical social science literature published english french german italian portuguese spanish estimates prevalence difficult obtain consensus criteria refuser status standardized definition practice studies sampling methodologic limitations white paper reviews data offers logical frameworks represent possible health health system consequences conscience based refusal provide abortion assisted reproductive technologies contraception treatment cases maternal health risk inevitable pregnancy loss prenatal diagnosis concludes categorizing legal regulatory policy responses practice conclusions empirical evidence essential varied political actors respond policies regulations competing concerns stake research training diverse geopolitical settings required dual commitments toward conscience obligations patients health rights providers professional medical public health societies must lead attempts respond conscience based refusal safeguard reproductive health medical integrity women lives international federation gynecology obstetrics published elsevier ireland ltd rights reserved
purpose consensus statement diagnostic chromosomal microarray cma testing recommended array resolution throughout genoine balance analytical clinical sensitivity spite clear evidence pathogenicity large copy number variants cnvs neurodevelopmental disorders congenital anomalies significance small nonrecurrent cnvs well established clinical setting methods investigated clinical significance nonpolymorphic small nonrecurrent cnvs patients referred cma clinical testing period years total patients excluded study patients benign likely benign cnvs patients recurrent microdeletions microduplications results total patients found carry least one small nonrecurrent cnv patients one small cnv classified variant uncertain significance vus two small vus cnvs one small vus cnv recurrent cnv one small pathogenic likely pathogenic cnv two small pathogenic likely pathogenic cnvs one small pathogenic likely pathogenic cnv recurrent cnv within pathogenic group patients small pathogenic cnv cases found single whole gene exonic deletion themes emerged study presented discussion section conclusions study demonstrates diagnostic clinical relevance small nonrecurrent cnvs cma clinical testing underscores need careful clinical interpretation cnvs
despite significant global burden gastroenteritis resulting sequelae limited evidence risk factors sequelae development updated extended previous systematic reviews assessing role antibiotics proton pump inhibitors ppi symptom severity development sequelae following campylobacteriosis salmonellosis searched four databases including pubmed january april observational studies reporting sequelae reactive arthritis rea reiter syndrome irritable bowel syndrome ibs guillain barre syndrome gbs following gastroenteritis included primary outcome incidence sequelae interest amongst cases campylobacteriosis salmonellosis narrative synthesis conducted heterogeneity high articles included incidence rea ibs gbs reported following campylobacteriosis salmonellosis pooled summary sequela estimated due high level heterogeneity across studies ppi usage symptoms sparsely reported three seven studies found statistically significant association antibiotics usage development rea additional primary studies investigating risk modifying factors sequelae infections required enable targeted interventions authors published elsevier open access article license http creativecommons org licenses
corrosion behaviour cenospheres metal matric syntactic foams different compositions nacl aqueous solution similar degrees investigated electrochemical properties composites assessed experimentally employing potentiodynamic polarisation electrochemical impedance spectroscopy measurements appropriate equivalent electrical circuits proposed results showed corrosion rate higher metal matrix syntactic foams compared pure sintered aluminium volume fraction cenospheres increases cenospheres fragments presence reaction zones seems greater effect corrosion behaviour composites compared presence unintended porosity
high throughput microfluidic flow cell array mfca system modified enable drug screening small volume cell tissue cultures mfca composed channel network simultaneously flows fluids forty eight flow cells physically divide fluidically seal existing culture multiple compartments docked onto surface cell tissue culture dish modified system provides temperature degrees level controls continuously flowing solutions media liquid drug suspensions cells tissues assays enhanced validated using inverted microscopy fluorescent staining techniques also allow real time viability toxicity assessments work presents results new generation vitro drug testing assay performed using modified mfca system setup allows testing drug combinations different cell tissue specimen flow conditions flow cells utilized test different concentrations cisplatin cddp cddp solutions various concentrations continually flowed cultured human ovarian cancer cells viability assessments performed using red orange calcein sytox green nucleic acid stains cells imaged beginning end experiment order compare validate mfcas suitability drug screening assay mtt assays performed cells found mtt mfca assays generated dose response curves similar profiles innovative advantages mfca system include ability handling smaller amounts solutions compared conventional current state art drug screening cell viability toxicity methods also provides ability continually deliver fresh solution cell samples eliminating wastes produced based reported findings mfca may strong potential providing physiological model current state art static mtt assays
theory based intervention strategy improve purchasing decision maker perceptions ventilated tools developed implemented tested intervention designed target key constructs prevention design adoption readiness model ptd arm previously published conceptual model web based intervention developed included information health effects construction dust testimonial firm owner video demonstrating side side use ventilated nonventilated tools provided visual evidence dust generation productivity performance pretest posttest control group experimental design purchasing decision makers contacted telephone validated survey instrument used collect perception data open ended responses regarding barrier information gain score test analysis found significant improvements perceived ease use health knowledge perceived risk intervention group open ended results identified barriers use ventilated tools intervention methods presented paper used future researchers occupational safety health practitioners improve use safety innovations american society civil engineers
preventing data exfiltration insiders challenging process since insiders users access permissions data existing mechanisms focus tracking users activities connected database unable detect anomalous actions users perform data gain access able detect anomalous actions data critical actions often sign attempts misuse data paper propose approach detect anomalous actions executed data returned users database approach implemented part provenance based anomaly detection data exfiltration pandde tool pandde leverages data provenance information captured operating system level information used create profiles users actions data retrieved database profiles indicate actions consistent tasks users actions recorded profiles include data printing emailing storage profiles used run time detect anomalous actions
one important aspects considered rheumatic musculoskeletal diseases patient activity capacity performance defined ability perform task currently assessed physicians health professionals mainly means patient reported questionnaire sometimes combined therapist judgment performance based tasks work introduces approach assess activity capacity home objective yet interpretable way offers pilot study patients suffering axial spondyloarthritis axspa demonstrate efficacy firstly protocol introduced recognize limited set six transition activities home environment using single accelerometer end hierarchical classifier rejection non informative activity segments developed drawing direct pattern recognition statistical signal features secondly recognized activities assessed similarly scoring performed patients achieved interval coded scoring ics system novel method extract interpretable scoring system data activity recognition reaches average accuracy assessment currently accurate results indicate potential approach next step validation larger patient study
paper proposes new approach field programmable gate array fpga controlled digital implementation shunt active power filter sapf steady state dynamic operations typical implementations sapf uses microprocessor digital signal processor dsp limited complex algorithm structure absence feedback loop delays cost exceed benefit bring paper hardware resources fpga configured implemented order overcome conventional microcontroller digital signal processor implementations proposed fpga digital implementation scheme less execution time boosts overall performance system fpga controller integrates entire control algorithm sapf including synchronous reference frame transformation phase locked loop low pass filter inverter current controller etc required algorithms implemented single chip fpga module provides freedom reconfigure applications entire algorithm coded processed simulated using xilinx ise suite estimate advantages proposed system coded algorithm also defused single chip xilinx spartan dsp xcsd laboratory prototype experimental results thus obtained match simulated counterparts dynamic state steady state operating conditions
background earlier research investigated association parental separation long term health outcomes among offspring studies assessed potentially moderating role mental health status adolescence aim study analyze whether parental separation childhood predicts depression adulthood whether pattern differs individuals without earlier depression methods community based sample individuals adolescent depression matched non depressed peers followed using structured diagnostic interview years participation rate depressed non depressed controls information parental separation conditions childhood adolescence collected baseline outcome depression ages years information depression collected follow diagnostic interview statistical method used binary logistic regression results analyses showed depressed adolescents separated parents excess risk recurrence depression adulthood compared depressed adolescents non separated parents addition among adolescents depression parental separation associated increased risk switch bipolar disorder adulthood among matched non depressed peers associations parental separation adult depression bipolar disorder found conclusions parental separation may long lasting health consequences vulnerable individuals suffer mental illness already adolescence
investigation paper propagation interaction solitons formed incoherently interacting optical beams bulk kerr saturable media nonlinear optical fibers governed dimensional coupled nonlinear schrodinger system via symbolic computation hirota method analytic mixed type vector one two soliton solutions system derived bright dark vector solitons taken example graphically illustrate propagation interaction mixed type vector solitons analysis vector one solitons soliton amplitude width found depend index refraction absolute value index refraction increases bright soliton amplitude dark soliton width become larger inelastic elastic overtaking interactions bright two solitons elastic oblique interaction dark two solitons illustrated see bright soliton larger amplitude moves faster overtakes smaller increasing absolute value index refraction obtain dark soliton larger velocity soliton amplitudes change inelastic interaction keep invariant elastic interaction elsevier rights reserved
vlsi technology advances towards nanoscale devices interconnect delay becoming increasingly important could effectively reduced using buffer insertion widely used buffer insertion technique industry insert set buffers chip may overlap gates greedily move buffers nearest available buffer holes moving distance inserted buffers largely affects wirelength may result increase interconnect delay necessitates efficient algorithms minimize moving distance buffers effective buffer insertion obtain high performance vlsi designs paper proposes efficient perturbation constrained buffer planning algorithm maximize candidate buffer holes regarding feature cps based buffering design framework instead directly moving buffers existing available buffer holes proposed algorithm changes original placement moving gates tinily provide flexibility buffer insertion integer linear programming based technique designed physical design flow allows small moving range gates parallel technique utilized solve ilp problems efficiently scale chip increasing experimental results shown proposed algorithm achieves increase available buffer holes compared algorithm gate movement elsevier inc rights reserved
one features construction industry last three decades use various procurement methods projects management contracting project management design build growth use methods number researchers investigated criteria selection performance terms time cost quality however lack reporting association procurement methods advanced related issues innovation technology supply chain lean construction buildability sustainability value management selected papers well known academic journals construction management detailed coverage issues systematically reviewed aim investigate state art trends procurement research outcome paper may provide platform researchers industrial practitioners appreciate latest developments trends procurement method research authors published elsevier
first impressions made photographs faces depend much momentary characteristics photographed image within person variability consistent properties face person depicted person variability examine two important sources within person variability emotional expression viewpoint find within person variability person variability social impressions key traits trustworthiness dominance attractiveness index main dimensions theoretical models facial impressions important source variability emotional expression face viewpoint photograph also affects impressions modulates effects expression example faces look trustworthy happy expression facing perceiver compared facing elsewhere whereas opposite true anger disgust findings highlight integration different sources variability social impression formation
difficulty engineering student materials engineering courses related learning materials seem abstract learning atomic crystal structure important determine material properties particular mechanical properties strength material study focused increasing quality learning materials engineering particular metal reinforcement specific target research produce multi media learning animation atomic structure research procedures using research development approach carried two stages results first stage multi media animation mma metal reinforcement material influence mechanical properties mma stages evaluation development focus group discussion fgd involving media experts practitioners
migraine common recurrent neurological disorder combining nausea vomiting hypersensitivities visual auditory olfactory somatosensory stimuli however dysfunction sensorimotor network migraineurs well clarified present study evaluated dysfunction sensorimotor network migraineurs without aura controls combining regional homogeneity reho amplitudes low frequency fluctuation alff degree centrality analysis methods based resting state fmri seed based functional connectivity analysis used investigate whether dysfunctional areas within sensorimotor network exhibited abnormal brain areas compared controls migraineurs without aura exhibited significantly smaller reho alff values primary somatosensory cortex right premotor cortex pmc migraineurs showed weaker brain areas within pain intensity spatial discrimination pathways trigemino thalamo cortical nociceptive pathway proposed dysfunction pmc decreased brain areas migraineurs without aura may disrupt discrimination sensory features pain affect nociception pathways would involved dysfunctional mechanism migraine
ins films grown preheated glass substrate spray pyrolysis indium chloride thiourea molar ratio used reagents substrate temperature fixed films adhered well substrate approximately thick structural morphological optical electrical properties grown ins films studied use ray diffraction xrd analysis energy dispersive spectroscopy atomic force microscopy afm optical absorption spectroscopy impedance spectroscopy xrd revealed well crystallized films oriented direction corresponding cubic beta ins phase surface films smooth average roughness afm image revealed films nanopolycrystalline contained grains range optical transmission visible near infrared regions direct band gap energy electrical data analyzed basis impedance cole cole plots frequency range khz room temperature constant phase elements used equivalent electrical circuits fitting experimental impedance data experimental results fitted equivalent electrical circuit use view software conductivity grains grain boundaries estimated gas sensing properties sample investigated basis change conductance result adsorption desorption atmospheric oxygen
study explains design implementation virtual reality framework fun based interactive programming instruction engineering education courses students continue face several difficulties learning programming lack efficient tools overcome difficulties affect students motivation time creates drastic negative impact attitude towards learning programming undesirable student success engineering education rectify suitable approach motivate students needs developed change students mindset towards learning programming student motivation considered imperative directly influences student perseverance dedication towards accomplishing objective rather viewing programming courses means complete coursework requirements students made realize power programming learning gaining experience computer programming necessarily involves development computational critical thinking problem solving skills skills sharpen minds students simultaneously opening multiple job prospects upon graduation end facilitate interactive funfilled learning research employs learner centric user friendly virtual environment teach programming concepts research aims make paradigm shift approach teaching learning programming
online hosts networks easy targets network attacks due static nature creates information asymmetry makes easy attack hard defend break asymmetry moving target defense proposed bring uncertainties computer systems applied levels protections covering applications system software operating systems networks paper present sniffer reflector new method practice moving target defense network reconnaissance usually considered first step attacks sniffer reflector employs software defined networking disturb network reconnaissance use virtualization provide obfuscated reconnaissance result attackers method easily combined existing security tools network forensics well developed prototype virtual local area network experiment results show sniffer reflector effective efficient blurring various network reconnaissance
mutant hypothyroid mouse models recently shown thyroid hormone critical skeletal development important prepubertal growth period additionally thyroid hormone negatively regulates total body fat consistent well established effects thyroid hormone energy fat metabolism since bone marrow mesenchymal stromal cells differentiate adipocytes osteoblasts relationship bone marrow adipogenesis osteogenesis predicted hypothesized thyroid hormone deficiency postnatal growth period increases marrow adiposity mice marrow adiposity deficient tshr mice treated receptor beta specific agonist vehicle control evaluated via dual energy ray absorptiometry osmium micro computed tomography examine mechanism thyroid hormone regulation marrow adiposity used real time pcr measure effects thyroid hormone adipocyte differentiation markers primary mouse bone marrow mesenchymal stromal cells two mouse cell lines vitro tshr mice vivo marrow adiposity increased tshr mice weeks age treatment serum thyroid hormone normally increases day rescued phenotype furthermore rescued phenotype equally well suggesting thyroid hormone effect part mediated via beta signaling treatment bone marrow mesenchymal stromal cells significantly increased expression several brown beige fat markers moreover injection increased browning specific markers white fat tshr mice data suggest thyroid hormone regulation marrow adiposity mediated least part via activation beta signaling
automatically describing content image fundamental problem artificial intelligence connects computer vision natural language processing paper present generative model based deep recurrent architecture combines recent advances computer vision machine translation used generate natural sentences describing image model trained maximize likelihood target description sentence given training image experiments several datasets show accuracy model fluency language learns solely image descriptions model often quite accurate verify qualitatively quantitatively finally given recent surge interest task competition organized using newly released coco dataset describe analyze various improvements applied baseline show resulting performance competition aequo team microsoft research
purpose resilience stressful life events sles increase risk psychopathology influenced genetic factors purpose paper map overlap etiologic risk factors resilience onto broad psychopathological map resilience defined difference twins total score broad measure internalizing symptoms predicted score based cumulative exposure sles methods cholesky decompositions performed openmx quantify overlap genetic environmental risk factors resilience four phenotypes major depression generalized anxiety disorder gad alcohol abuse dependence aad antisocial personality disorder aspd results genetic factors influence resilience account heritability gad respectively aad aspd respectively latent genetic contribution shared resilience aad estimate lower shared environmental covariance nominal conclusions genetic influences resilience contribute internalizing phenotypes higher degree externalizing phenotypes environmental influences also enduring effect resilience however virtually covariance resilience phenotypes genetic
decision table firstly proved effective pair equivalent improved discernibility matrix guarantee attribute reduction based discernibility matrix calculated effective pair get attribute reduction quickly parallel radix sort model proposed simple decision table effective pair obtained taking length distinguishable indistinguishable elements string among effective pair heuristic information attribute reduction algorithm based parallel logical proposed finally examples experiments shown verify effectiveness feasibility proposed algorithm
respect current vulnerable climatic condition water quality become matter highest worldwide concern rainwater harvesting acceptable solution overcoming problem among various rainwater harvesting systems green roof rainwater harvesting significant tool improving standard living rapidly growing populations whole world terms water demand protecting environment pollution paper assesses water quality parameter dissolved oxygen conductivity temperature rainwater harvesting green roofs humid tropic center tropical climate conditions shows values electric conductivity always within class according interim national water quality standards inwqs water quality index wqi depletions values observed green roof runoff runoff quality ranged class iii inwqs wqi lower value indicates harvested rainwater green roofs acidic standard neutral value harvested water must processed general water treatment methods like filtration disinfection reverse osmosis storage tank indoor temperatures always within acceptable range
objective study designed examine independent combined associations physical activity smoking incidence doctor diagnosed insomnia using nationally representative sample seven years taking account relevant covariates methods participants aged years older taiwan national health interview survey nhis links national health insurance nhi claim data without diagnosed insomnia selected study participants classified insomnia international classification diseases ninth revision icd codes self reported smoking status frequency duration types leisure time non leisure time physical activities collected metabolic equivalent met intensity levels activity assigned weekly energy expenditure activity calculated summed results inactive participants higher risk incident insomnia hazard ratio confidence interval active group ever smokers likely incident insomnia never smokers compared nonsmoker active group ever smoker inactive group higher risk incident insomnia sensitivity analyses excluding individuals diagnosed sleep disorders mental disorders yielded similar results ever smoker inactive group highest risk insomnia conclusions inactive adults smokers higher risk incident insomnia highlighting importance healthy lifestyle pointing strategies encouraging smoking cessation physical activity avoid insomnia among adults elsevier rights reserved
multistate survival analysis sojourn patient various clinical states shown correspond diffusion electrical charge electrical network essential comparison differentials probability patient correspond differentials charge equates clinical states electrical nodes indeed death state patient corresponds sink node circuit transient current would seen oscilloscope sink output plot probability density survival time patient electrical circuit analogy explored considering simplest possible survival model two clinical states alive dead sink incorporates censoring truncation sink output seen oscilloscope plot kaplan meier mass function thus kaplan meier estimator finds motivation dynamics current flow fundamental physical law rather nonparametric maximum likelihood estimate mle generalization competing risks settings multiple death states sinks leads cause specific kaplan meier submass functions outputs sink nodes covariates present electrical analogy provides intuitive understanding partial likelihood various baseline hazard estimates often used proportional hazards model
purpose work demonstrate rapid prototyping effectively applied fabricating test models used aerodynamic experimental investigations one popular technology used worldwide printing printing technologies divided following groups inkjet printing fused deposition modelling polyjet present work focused applications polyjet technology manufacturing aerodynamic parts implicitly indicates effectiveness employing polyjet technology fabricating wind tunnel test models second part paper presented case study using eden printing system objet available transilvania university brasov department manufacturing engineering
background four single nucleotide polymorphisms snps modulator recognition factor rich interaction domain mrf aridb gene located chromosome shown associated type diabetes mellitus tdm coronary artery disease japanese cohort study aimed investigate relationship snps new onset tdm lipid metabolism northern chinese population methods case control study genetic variants genotyped snpscan analyzed relation tdm susceptibility individuals newly diagnosed tdm controls without diabetes mellitus associations mrf aridb genetic models tdm determined multivariate logistic regression results regarding snp associated higher risk tdm compared codominant type adjusted sex age body mass index bmi odds ratio confidence interval meanwhile individuals increased risk presenting tdm compared individuals single adjusted sex age bmi respect rsl contributed higher risk tdm compared adjusted sex age bmi also increased risk presenting tdm compared adjusted sex age bmi high density lipoprotein cholesterol hdl levels significantly different among three genotypes controls conclusions present results identified mrf arjdb potential susceptibility gene new onset tdm northern chinese population snp associated hdl levels larger studies required validate findings
new stochastic finite element model calibration framework estimation uncertainty model parameters predictions measured frequency responses proposed paper combines principles bootstrapping technique model calibration damping equalization challenge calibration problem find initial estimate parameters reasonably close global minimum deviation model predictions measurement data idea model calibration damping equalization formulate calibration metric deviation logarithm frequency responses model test data model found measurement level modal damping imposed modes formulation gives smooth metric large radius convergence global minimum study practical suggestions made improve performance calibration procedure dealing noisy measurements dedicated frequency sampling strategy suggested measurement frequency responses order improve estimate test data model deviation metric frequency line weighted using signal noise ratio measured frequency responses solution improved calibration procedure damping equalization viewed starting value optimization procedure used uncertainty quantification experimental data resampled using bootstrapping approach model calibration problem initiating estimated starting value solved individual resampled dataset produce uncertainty bounds model parameters predictions proposed stochastic model calibration framework demonstrated six degree freedom spring mass system prior applied general purpose satellite structure
novel approach using microresonating system low power consumption proposed determining young modulus mirco nano sized waveguide material based mason rule signal flow graph sfg method domain optical transfer function derived resonating layout consists two single microring resonators indirectly coupled add drop micro resonator mathematical function determined critical coupling coefficient optimum optical transmission proposed system resonant mode numbers free spectral range fsr extended band rejection ratio obrr factor young modulus determined based change sensing ring radius due applied external force waveguide causes wavelength shift resonant peaks young modulus lateral surface soi waveguide height radius determined gpa upper surface soi waveguide average width radius determined gpa proposed resonating system potential candidate measuring young modulus materials mirco nano size high resolution advantages low power consumption due low intensity source
individual factors associated hiv testing studied across multiple populations however testing individual level phenomenon secondary analysis ethiopia demographic health survey data conducted determine extent institution opt policy hiv testing antenatal care increased testing among women whether effects differed women stigmatizing beliefs hiv logit model interaction pre post policy year policy exposure birth past year used estimate increased probability past year testing may attributable policy results suggested policy contributed nine point increase probability testing three way interaction used compare effects exposure policy among women holding higher lower hiv stigmatizing beliefs increase probability past year testing percentage points greater among women lower stigmatizing beliefs women higher stigmatizing beliefs less likely report attending antenatal care anc testing last anc visit offered test last anc visit encourage researchers practitioners explore interventions operate multiple levels socio ecological spheres influence addressing stigma structural barriers testing order achieve greatest results preventing hiv
fda approved antidepressant smoking cessation drug bupropion known inhibit dopamine norepinephrine reuptake transporters well nicotinic acetylcholine receptors nachrs cation conducting members cys loop superfamily ion channels broadly pentameric ligand gated ion channels plgics present study examined ability bupropion primary metabolite hydroxybupropion block function cation selective serotonin type receptors characterized bupropion pharmacological effects receptors mouse heterologously expressed hem cells xenopus laevis oocytes equilibrium binding studies addition latter expression system utilized functional studies employing two electrode voltage clamp recordings bupropion hydroxybupropion inhibited serotonin gated currents reversibly dose dependently inhibitory potencies respectively notably measured value hydroxybupropion within therapeutically relevant concentrations blockade bupropion largely non competitive non use dependent unlike modulation cation selective plgics bupropion displayed significant inhibition function anion selective plgics summary results demonstrate allosteric blockade bupropion htar importantly given possibility bupropion major active metabolite may achieve clinically relevant concentrations brain novel findings delineate yet identified pharmacological principle underlying antidepressant effect elsevier ltd rights reserved
phase noise correction crucial exploit full advantage orthogonal frequency division multiplexing ofdm modern high data rate communications ofdm channel estimation simultaneous phase noise compensation therefore drawn much attention stimulated continuing efforts existing methods however either taken account fundamental properties phase noise able provide estimates limited applicability owing considerable computational complexity paper reformulated joint phase noise channel estimation problem time domain opposed existing frequency domain approaches enables develop much efficient algorithms using majorization minimization technique addition propose two methods based dimensionality reduction regularization respectively adapt various phase noise levels signal noise ratio achieve much lower estimation errors benchmarks without incurring much additional computational cost several numerical examples phase noise generated free running oscillators phase locked loops demonstrate proposed algorithms outperform existing methods respect computational efficiency mean squared error within large range snrs
year old adolescent boy presented atypical major depressive episode mde without specific focal neurological signs months diagnosis intracranial germinoma atypical mde symptoms subsided operation however relapse atypical mde months first surgery mood binge eating symptoms subsided intractable body weight gain partially improved treatment encountering manifestations depression atypical features especially binge eating symptoms male children adolescents early onset age family history prolonged depressive episodes clinicians consider mood disorders including bipolar spectrum disorders also organic brain lesions intracranial germinoma
chronic itch inflammatory skin diseases atopic dermatitis markedly diminishes quality life affected individuals comprehensive progress made understanding itch signaling associated mediators skin dorsal root ganglia spinal cord central nervous system may amplify suppress atopic itch conventional therapies atopic dermatitis capable reducing atopic itch however patients satisfied antipruritic capacity conventional treatments exploring itch pathways mechanisms may lead novel therapeutic approaches atopic itch
dopamine required reinforcement learning hence disruptions signaling may contribute learning deficits associated psychiatric disorders receptor linked learning target cognitive motivational enhancement patients schizophrenia separating striatal contribution learning motivation however challenging suppressed striatal expression mice using targeting short hairpin rna shrna delivered locally striatum via adeno associated virus aav assessed reward punishment associative learning using probabilistic learning task motivation using progressive ratio breakpoint procedure confirmed suppression striatal drs immunohistochemically testing locomotor activity administration doxanthrine full agonist control mice treated drshrna drshrna treated mice exhibited impaired reward associative learning punishment associative learning spared deficit unrelated general learning impairments amotivation dshrna treated mice exhibited normal barnes maze learning normal motivation progressive ratio breakpoint procedure suppression striatal drs selectively impaired reward associative learning whereas punishment associative learning aversion motivated learning appetitive motivation spared patients schizophrenia exhibit similar reward associative learning deficits targeted treatments investigated improve reward learning patients elsevier rights reserved
moral appeals altruism means influence people prosocial behavior common especially organ donation communicators might consider conceptions altruism differ among people cultures scholars organ donation employing altruism main appeal contested propose using solidarity reciprocity alternative prosocial appeals qualitative study explored views people diverse israeli groups focus groups medical professionals regarding appropriateness employing moral appeals organ donation analysis presents frameworks contrasting conceptions altruism point potential unintended effects applying restrictive conception also identifies communication challenges associated introducing solidarity reciprocity prosocial value laden persuasive appeals
introductiondirect consumer ads testosterone replacement therapies significantly increased past several years subsequently testing low serum testosterone correspondingly increased aimswe sought determine testing behaviors practitioners well characteristics men undergoing testing low testosterone methodsmen aged years queried institutional electronic data warehouse men considered tested serum total testosterone level measured purpose tested men compared tested main outcome measuresthe frequency timing testing low testosterone well patient demographics clinical characteristics compared using multivariable logistic regression models resultsof total men underwent testing serum total testosterone mean age years frequency testing increased study period multivariable analysis demonstrated significantly likely caucasian increased body mass index addition significantly likely comorbid conditions including decreased libido adjusted odds ratio aor confidence interval infertility aor erectile dysfunction aor osteoporosis aor depression aor prostate cancer aor hypertension aor chronic obstructive pulmonary disease aor benign prostatic hyperplasia aor among men underwent testing conclusionsthe rate testosterone testing increasing testing practices directed toward subset men comorbidities associated hypogonadism compliance physicians obtaining early morning serum testosterone levels low education practitioners required appropriately test patients hypogonadism malik lapin wang lakeman helfand testing appropriately low testosterone characterization tested men compliance current guidelines sex med
novel carbon monoxide sensor fabricated based quartz crystal microbalance qcm using commercial piezoelectric crystal modified single walled carbon nanotubes swcnts spin coating technique purpose alternative current potential frequency mhz optimum surface acoustic wave saw applied piezoelectric crystal saw device follow linear correlation mass difference frequency gradient frequency voltage converter adopted using integrated circuit output potential filtered electrical high pass filter followed fold samplification using operational amplifier finally connection voltmeter according figures merit fabricated sensor linear parts per million ppm detection limit also similar ppm relative standard deviation six replicate analyses based maximum response response time recovery time also evaluated similar atmosphere pressure calibration sensitivity measured ppm significant interference observed introducing least folds various foreign species air diluents reliability sensor finally evaluated via determination two samples
research shows positive mood serve broaden scope attention perceptual conceptual level increasing size spatial attentional focus semantic access remote associates investigated whether relaxation attentional filters positive affect reduces selectivity basic visual features induced positive neutral negative affect asked observers identify target motion direction series rapid random moving dot displays using reverse correlation method examined differential effects emotion observers perceptual tuning curves motion direction find positive affect reduces selectivity motion direction broadening observers perceptual tuning relative neutral negative affect conditions findings provide first behavioral evidence positive emotion influences selectivity basic visual features modulation tuning properties
present systematic review meta analysis aimed assess compare safety efficacy radiofrequency cryoballoon ablation paroxysmal atrial fibrillation paf ablation two frequently used methods pulmonary vein isolation paf better choice paf remains uncertain systematic review conducted medline pubmed embase cochrane library trials comparing ablation screened included inclusion criteria met total eligible studies prospective randomized randomized controlled trials rcts non rcts identified adding patients pool analyses indicated ablation beneficial terms procedural time standard mean difference confidence interval complications without phrenic nerve injury pni odds ratio recrudescence paf however total complications higher subgroup analysis found compared non contact force radiofrequency non first generation cryoballoon second generation cryoballoon ablation could reduce complications pni procedural time recrudescence however safety efficacy similar available overall subgroup data suggested beneficial ablation main advantages reflected comparing non however showed similar clinical benefits
quest energy efficient information communication technology research mostly focused role hardware however impact software energy consumption acknowledged significant researchers software engineering spite due cost time constraints many software producing organizations unable effectively measure software energy consumption preventing include energy efficiency product roadmap paper apply software energy profiling method reliably compare energy consumed commercial software product across consecutive releases demonstrate method applied provide depth analysis energy consumption software components additionally investigate added value measurement multiple stakeholders software producing organization means semistructured interviews results show introduction encryption module caused noticeable increase energy consumption product results deemed valuable stakeholders provided insights specific software changes might affect energy consumption addition interviews show quantification software energy consumption helps create awareness eventually consider energy efficiency aspects planning software releases
atherosclerosis leading cause morbidity mortality multifactorial disease preferentially occurs regions arterial tree exposed disturbed blood flow detailed mechanisms flow induces atherosclerosis involve changes expression genes epigenetic patterns metabolites multiple vascular cells especially endothelial cells review presents overview endothelial mechanobiology relation pathogenesis atherosclerosis special reference anatomy artery underlying fluid mechanics followed discussion variety experimental models study role fluid mechanics atherosclerosis various vitro vivo models study role flow endothelial biology pathobiology discussed review furthermore strategies used global profiling genome transcriptome mir nome dna methylome metabolome important define biological pathophysiological mechanisms atherosclerosis omics approaches especially derive data based single animal model provide unprecedented opportunities better understand pathophysiology atherosclerosis development holistic integrative manner also identify novel molecular diagnostic targets elsevier inc rights reserved
academic research technological innovation associated rainwater harvesting rwh systems seen shift emphasis recent years traditional design approaches use whole life cost assessments prioritise financial savings associated provision alternative water supply however researchers practitioners increasingly recognising broader benefits associated rainwater reuse stormwater attenuation benefits paper identifies describes set novel rwh system configurations potential deployment houses conceptual schematics provided define innovations alongside traditional configurations discussion drivers supporting configurations illustrates opportunities rwh deployment wide range settings quantitative multi criteria analysis used evaluate score configurations range emerging criteria work identifies several rwh system configurations outperform traditional ones terms specified cost benefits selection specific rwh technology shown highly dependent user priorities proposed system configurations highlighted could enable rwh cost effectively installed broad set contexts experienced minimal exploitation date
order cheybshev ladder active bpf fabricated cmos low leakage digital process new technique design zero capacitance spread zcs reported enable application integrator frequency compensation ifc combined wideband amps employing current reusing split path feed forward compensation ffc technique significant power savings achieved standard cmos process bpf measures center frequency mhz four programmable bandwidth center frequency ratios ratio digitally programmable also measures maximum band iip dbm gain maximum band frequency response deviation consuming supply
although researchers found child welfare placement disruptions associated elevated youth physical mental health problems mechanisms explain association previously studied present study built previous investigation physical behavioral consequences long term permanent placement patterns among youth participated longitudinal studies child abuse neglect longscan current investigation aimed report early adolescent living situations youth different long term placement patterns delineate roles adverse childhood experiences aces post traumatic stress pts reactions association unstable long term placement patterns physical mental health problems transition adolescence information youth living situations aces physical mental health gathered prospectively child protective services records biannual caregiver youth interviews youth years old majority youth remained caregiver early adolescence youth chronically unstable permanent placement patterns continued experience instability path analyses revealed aces mediated association unstable placement patterns elevated mental physical health problems late childhood additionally late childhood pts mediated association unstable placement patterns subsequent escalations physical mental health problems transition adolescence findings highlight importance long term permanency planning youth enter child welfare system emphasize importance trauma focused assessment intervention youth elsevier ltd rights reserved
mexico small medium size enterprises smes key software development industry highly qualified personal development high quality software products fundamental piece guarantee permanency market therefore matching software industry requirements academy training represents significant problem must addressed sectors benefit paper presents analysis coverage moprosoft norm standard developed used software industry ensure quality software engineering practices ten academic curricular programs higher education related computer science informatics get overview knowledge skills computer science students acquire universities regarding knowledge required organizations work process models addition survey smes conducted contrast coverage results hired recently graduated personal
paper considers feedback cellular neural network cnn obtained interconnecting elementary cells ideal capacitor ideal flux controlled memristor supposed analogue computation cnn memristors behave dynamic elements dynamic memristor cnn cell described second order differential system state variables given capacitor voltage memristor flux proposed networks called cnns cnns using dynamic memristor giving foundation cnn model paper establishes fundamental result complete stability convergence solutions toward equilibrium points cnn symmetric interconnections presence dynamic memristors cnn displays peculiar basically different dynamic properties respect standard cnns first cnn computes time evolution memristor fluxes instead capacitor voltages standard cnn furthermore steady state reached memristors keep memory result computation limiting values fluxes memristor currents voltages well currents voltages power cnn vanish instead standard cnns currents voltages power drop steady state reached copyright john wiley sons ltd
objectivethe objective evaluate body movement oriented intervention aggression regulation specifically aimed towards reducing anger internalization patients eating disorder methodpatients randomized treatment usual tau plus intervention tau intervention delivered psychomotor therapist tau consisted multidisciplinary day treatment days per week months anger coping self expression control scale eating pathology eating disorder examination self report questionnaire measured baseline follow differences pre intervention post intervention scores tested using repeated measures anova resultsthe intervention group showed significantly larger decrease anger internalization control group groups showed significant reduction eating pathology differences groups significant discussiona body movement oriented therapy seems viable add treating anger internalization patients eating disorder copyright john wiley sons ltd eating disorders association
study present new theory partitioning disease prevalence incidence based mortality demonstrate theory practically works analyses medicare data theory prevalence disease incidence based mortality modeled terms disease incidence survival diagnosis supplemented information disease prevalence initial age year available dataset partitioning trends prevalence mortality calculated minimal assumptions resulting expressions components trends given continuous functions data estimator consistent stable developed methodology applied data type diabetes using individual records nationally representative sample medicare beneficiaries age numerical estimates show excellent concordance empirical estimates theoretical predictions evaluated partitioning model showed prevalence mortality increase time primary driving factors observed prevalence increase improved survival increased prevalence age increase diabetes related mortality driven increased prevalence unobserved trends time periods age groups outside range data used study finally properties new estimator possible statistical systematical uncertainties future practical applications methodology epidemiology demography public health health forecasting discussed elsevier inc rights reserved
positive credit history rating help consumers good payment history get lower interest rates greater flexibility credit well loans longer payment terms order establish credit profiles need get information spending patterns consumers companies selling related goods problem share private information customers companies without compromising secrecy confidentiality information work propose cryptographic protocol share sensitive information preserving privacy customer well information commercial institution furthermore analyse proposed protocol using petri nets verify absence livelocks deadlocks anomalies protocol
internet things wireless data communications technology radio frequency identification rfid emerging technology automatic identification internet things fact means use rfid system identification technology internet achieve application information interconnection sharing paper author analyzes improved rfid middleware architecture optimal algorithm based internet things analysis rfid middleware technology put forward optimized load balancing algorithm results show optimization algorithm superior existing algorithms average time load balancing label processing
enterogenous cysts ecs endodermal lesions resulting splitting anomalies neuroenteric canal report case year old patient presented sudden headache followed collapse brain computed tomography revealed hyperdense lesion anterior part third ventricle obstructive hydrocephalus presumptive diagnosis colloid cyst made underwent right transcortical approach lesion resection histopathological examination revealed ecs common lesions cervical thoracic spine rare supratentorial compartment two previously described cases occurring third ventricle
classic strength materials theory considers plane stresses beams subjected pure bending negligible work undertakes theoretical analysis proposition basing development airy functions polar coordinates purpose research studying effect kind stresses structures fabricated non isotropic materials specifically multi component sandwich beams subjected pure bending large deflections studied analytical model proposed allows plane stresses calculated according curvature change design parameters specific structure completed model used calculate plane stresses different design configurations order study effects finally results compared finite element model
image enhancement edge preserving denoising relevant steps classification postprocessing techniques remote sensing images however multisensor array systems able simultaneously capture several low resolution images area different wavelengths forming high spatial spectral resolution image raising series new challenges paper open computing language based parallel implementation approach presented near real time enhancement based bayesian maximum entropy bme well edge preserving denoising algorithm remote sensing imagery uses local linear stein unbiased risk estimate llsure bme selected results synthetic aperture radar image enhancement whereas llsure shown better noise removal properties commonly used methods within context image processing methods algorithmically adapted via parallel computing techniques efficiently implemented using cpus commodity graphics processing units gpus experimental results demonstrate reduction computational load real world image processing near real time gpu adapted implementation
objective examine association pain catastrophizing pain experience history childhood sexual abuse women chronic pelvic pain cpp gynecologic origin study design cross sectional study women cpp attending tertiary care obstetrics gynecology pain clinic subjects completed standardized questionnaires assess pain intensity pain interference daily activity pain catastrophizing severity depressive symptoms history childhood sexual abuse results correlational analysis indicated pain catastrophizing pain intensity pain interference depression scores shared significant association multiple regression analysis indicated controlling influence depressive symptoms pain intensity pain interference pain catastrophizing significantly predicted pain outcome measures controlling pain catastrophizing depressive symptoms found significantly influence pain interference pain intensity abuse measures women reported major sexual abuse childhood found endorse severe pain catastrophizing conclusion pain catastrophizing appears important variable understanding pain experience women chronic pelvic pain presence history major sexual abuse childhood may additional risk factor pain catastrophizing population contributing pain morbidity
aim computational molecular design identification promising hypothetical molecules predefined set desired properties address issue accelerating material discovery state art machine learning techniques method involves two different types prediction forward backward predictions objective forward prediction create set machine learning models various properties given molecule inverting trained forward models bayes law derive posterior distribution backward prediction conditioned desired property requirement exploring high probability regions posterior sequential monte carlo technique molecules exhibit desired properties computationally created one major difficulty computational creation molecules exclusion occurrence chemically unfavorable structures circumvent issue derive chemical language model acquires commonly occurring patterns chemical fragments natural language processing ascii strings existing compounds follow smiles chemical language notation backward prediction trained language model used refine chemical strings properties resulting structures fall within desired property region chemically unfavorable structures successfully removed present method demonstrated design small organic molecules property requirements homo lumo gap internal energy package iqspr available cran repository
digital tomosynthesis three dimensional imaging technique lower radiation dose computed tomography due missing data tomosynthesis systems ofplane structures depth direction completely removed reconstruction algorithms work analyzed impulse responses common tomosynthesis systems plane plane basis proposed fast accurate convolution based blur add baa model simulate backprojected images addition analysis formalism describing impulse response plane structures generalized rotating parallel gantries implemented ray tracing forward projection backprojection ray based model algorithm convolution based baa model simulate shift add backproject tomosynthesis reconstructions convolution based baa model proper geometry distortion correction provides reasonably accurate estimates tomosynthesis reconstruction numerical comparison indicates simulated images using two models differ less terms root mean squared error convolution based baa model used efficient system geometry analysis reconstruction algorithm design plane artifacts suppression tomosynthesis registration
nonalcoholic fatty liver disease nafld encompasses range liver pathology ranging simple steatosis varying degrees inflammation hepatocyte injury fibrosis without intervention progress end stage liver disease hepatocellular carcinoma given close association obesity prevalence nafld increased dramatically worldwide currently fda approved medications treatment nafld although lifestyle modifications appropriate diet exercise shown beneficial difficult achieve sustain majority patients search effective therapeutic agents active area research peroxisome proliferator activated receptors ppars belong class nuclear receptors key role transcriptional regulation mediators glucose lipid metabolism ppar ligands investigated possible therapeutic agents review current evidence preclinical clinical studies investigating therapeutic potential ppar ligands treatment nafld elsevier societe francaise biochimie biologie moleculaire sfbbm rights reserved
zebrafish become popular animal model studying development alcohol addiction several behavioral paradigms studying alcohol addiction developed zebrafish including conditioned place preference alcohol induced tolerance withdrawal however alcohol choice preference tasks established zebrafish yet ability zebrafish detect alcohol environment required alcohol choice preference tasks knowledge currently unknown whether zebrafish able detect alcohol environment immediately following bath immersion current study analyzed time course alcohol induced behavioral changes zebrafish immersed alcohol solution tank recorded trial high definition quantified behavioral responses using automated video tracking based manual observation based methods quantify temporal changes alcohol induced behaviors alcohol known require several minutes bath immersion reach brain zebrafish argued behavioral responses time point would prove zebrafish ability detect substance water results show min exposure alcohol alters behavioral responses time dependent manner notably alcohol exposure significantly increased absolute turn angle decreased distance bottom variance distance bottom within first min immediately following exposure response occurred alcohol could reach brain subjects measurable amounts results imply zebrafish able detect alcohol environment immediately following immersion drug solution
paper presents methodology modeling repetitive construction projects introducing modeling procedure based system model simulator nexus aim developing intelligent tool facilitate decision making construction implementation phase study offers conceptualization construction processes designed monolithic construction computer aided system moccas enables flexible approach managing repetitive projects within dynamically changing construction environment discussion deals art modeling construction process introduces repetitive construction process formulated dynamic construction process model temporal perspective dcpm construction process representation three coordinate system managing assumed goals mag module designed simulate process behavior create execution strategies models capable handling variability construction process execution address complexity relations among production system components including resource mutual constraints case study discussed involves execution construction processes means slip formwork system exhibits large degree repetition therefore particularly useful example illustrating effectiveness modeling approach proposed original contribution research lies representing construction process acknowledging specificity deriving nature repetitive projects technological regime developing flexible structures dcpm mag enable construction process complexity addressed iii designing representation construction process within system model simulator nexus developed moccas significant outcome overall study development system capable harnessing cyclic nature repetitive processes converting repetitiveness vital asset construction management elsevier rights reserved
importance dietary fibre fractions animal feeding due influence rate passage mucosal functionality role substrate gut microbiota relates performance digestive health complexity physical structure chemical composition polysaccharides plant cell walls explains wide different physiological effects large range fibre fractions review first briefly consider definition structure different classes fibres cell wall constituents followed description analytical methods employed monogastric feeds second nutritional role impact fibre intake digestive health described growing rabbit extensive analysis previous studies performed without antibiotics fibres rabbit feed essential reducing risk digestive trouble weaning requirements defined terms quantity quality fibre fractions follows minimal dietary level lignocellulose adf lignins balanced maximum quantity digestible fibres dgf ratio dgf adf soluble fibres defined difference total dietary fibre ndf quickly fermented digested rabbit however impact digestive health still questioned
rationale patients single ventricle physiology high risk mortality resulting ventricular dysfunction preliminary results phase trial showed cardiosphere derived cells cdcs may effective congenital heart failure objective determine whether intracoronary delivery autologous cdcs improves cardiac function patients single ventricle physiology methods results conducted phase randomized controlled study assign ratio patients single ventricle physiology undergoing stage palliation receive intracoronary infusion cdcs weeks surgery staged reconstruction alone study primary outcome measure assess improvement cardiac function month follow four months palliation controls alternative option receive late cdc infusion request study secondary outcomes included ventricular function heart failure status somatic growth health related quality life month observation months absolute changes ventricular function significantly greater cdc treated group controls versus study late cdc infusion controls increased ventricular function months compared baseline versus year overall cdc infusion associated improved ventricular function versus volumes somatic growth increased trophic factors production insulin like growth factor hepatocyte growth factor quality life along reduced heart failure status cardiac fibrosis relative baseline conclusions intracoronary infusion cdcs staged palliation favorably affected cardiac function reverse remodeling patients single ventricle physiology impact may improve heart failure status somatic growth quality life patients reduce parenting stress families
osteoarthritis quality life scale oaqol specific individuals osteoarthritis present study describes adaptation oaqol use following five european languages german hungarian italian spanish turkish study involved three stages language translation cognitive debriefing face content validity validation validation stage assessed internal consistency cronbach alpha reproducibility test retest reliability using spearman rank correlations convergent divergent validity correlations health assessment questionnaire western ontario mcmaster universities index osteoarthritis nottingham health profile known group validity oaqol successfully translated target languages minimal problems cognitive debriefing interviewees found measures easy complete identified problems content internal consistency ranged test retest reliability reproducibility values indicate new language versions produce low levels measurement error median oaqol scores higher patients reporting current flare osteoarthritis countries scores also related expected perceived severity osteoarthritis oaqol successfully adapted use germany hungary italy spain turkey addition new language versions prove valuable multinational clinical trials clinical practice respective countries
modern operating systems oss expected secure integrate robust security measures ensure users perform daily tasks reliably article extensive experimentation evaluate today common oss fare typical address resolution protocol arp poisoning attack local area network lan test common variants linux along two variants mac one variant windows observe impervious arp poisoning also conclude mac vulnerable oss tested whereas tested variants linux windows show resilience toward attack even though windows believed less secure others
tilted wick type stepped solar stills well known increased distillate yield compared basin type stills study experiments conducted tilted solar still basin tilted solar still wick assess performance distillate quality environmental benefits economic feasibility distillate quality tested units superior annual average distillate yield tilted solar still basin nearly higher unit wick maximum distillate yield noticed tilted solar still basin wick respectively april yearly average thermal exergy efficiency around unit basin unit wick energy payback time unit basin around yrs prevent tons emission yrs life time distillate production cost around usd usd interest rate respectively tilted solar still basin superior performance compared unit wick produce distillate usd invested elsevier rights reserved
background accurate workplace injury data useful prioritization prevention strategies physicians report workplace ill health data within health occupation research thor network including injury case reports aims compare workplace injury data reported occupational physicians ops general practitioners gps thor methods injury cases reported ops gps reported thor analysed demographics industrial groups nature injury kind accident site injury compared data sickness absence workplace injuries reported gps investigated results total workplace injury cases reported ops gps males likely sustain workplace accident females sprains strains reported often upper limbs affected frequently slips trips falls identified important causal factors ops gps psychological injuries also featured thor reporting higher proportion reported ops gps proportion people classified unfit gps reduced following introduction fit note conclusions thor reports returned ops gps provide valuable source information workplace injury data complement sources information reporting injuries diseases dangerous occurrences regulations labour force survey
spondyloarthritis represents heterogeneous group articular inflammatory diseases share common genetic clinical radiological features recently novel insights epidemiology pathogenesis treatment diseases provided herewith present overview significant literature contributions published past year
society enter comprehensive network era mainly featured electronic commerce life closely computer network say life without computer network doubt network security important imagine survive unsafe computer network information transmitted truly completely effectively legally discuss topic network security paper includes meaning characteristics network security threats attacks faced computer network security measures safeguarding network network security technology introduction classification relationship overview firewall firewall key technology examples firewall application construction future development tendency firewall technology products etc
multiple reports context time taken read aloud joint effects stimulus quality word frequency interact words appear list additive nonwords intermixed words malley besner triple interaction explained terms idea different processing modes play different contexts processing cascaded words appear list allowing effect stimulus quality influence downstream process affected word frequency contrast nonwords appear list early process affected stimulus quality word frequency staged thresholded reduce probability lexicalizations reading nonword word stimulus quality low present experiment addresses issue whether thresholding presence nonwords driven orthography phonology nonwords included stimulus set participants read words aloud varied word frequency randomly intermixed nonwords sounded identical words brane brain stimulus quality word frequency additive effects time read aloud context consistent view orthography nonwords matters aspects results suggest level feed back play particular kind nonword used
investigate properties estimators obtained minimization processes lasso penalty high dimensional setting attention focused ranking problem popular machine learning related guessing ordering objects basis observed predictors prove oracle inequality excess risk considered estimator well bound distance theta cap theta estimator oracle besides study properties estimators simulated data sets elsevier rights reserved
analytically construct solutions mean first passage time splitting probabilities escape problem particle moving continuous brownian motion confining planar disc arbitrary distribution number size spacing exit holes absorbing sections along boundary governing equations quantities poisson equation non zero constant forcing term laplace equation respectively subject mixture homogeneous neumann dirichlet boundary conditions solutions expressed explicit closed formulae written terms parameterising variable via conformal map using special transcendental functions defined terms associated schottky group derived exploiting recent results related problem fluid mechanics describes unidirectional flow slip shear surfaces well results potential theory derived using theory schottky groups exact determination finite set mapping parameters performed numerically evaluation also requires numerical inversion parameterising conformal map computations series illustrative examples also presented
conventional rigid machines even biological systems nature generally capabilities like autonomous convergence divergence extraordinary behavior demonstrated first time liquid metal vehicle synthetic soft machine fueled aluminum flake could initiate autonomous locomotion open top circular channel containing naoh solution like running vehicle cutting large machine several smaller separately running vehicles still resumes traveling state along original track chases volumes dispersive vehicles close squeezed channel vehicles would move synchronously oscillation otherwise self motion would become desynchronized interval inequable vehicles decreased gradually volumes significantly different smaller vehicles squeezed channel faster vehicle would overtake slower ones finally coalesced seamlessly assembled vehicle could deform along change velocity finding may shed light future researches smart material fluid mechanics soft matter self fueled machine biomimics would also offer opportunities constructing self reconfigurable soft robots
hereditary angioedema hae rare disabling sometimes life threatening aim study describe prevalence symptomatology treatment sweden total patients identified adults children hae type giving minimum hae prevalence patients received written questionnaire followed structured telephone interview report focuses adults responded females reported attacks previous year males females reported days sick leave days males treated acute attacks plasma derived inhibitor concentrate pdclinh used patients good effect maintenance treatment used attenuated androgens used pdclinh reduced attack rate conclusion minimum hae prevalence sweden hae affected females severely attenuated androgens pdclinh good effect preventing attacks
examined relationship residential eviction exhibiting detectable plasma hiv rna viral load among prospective cohort antiretroviral therapy art exposed hiv seropositive people use illicit drugs pwud vancouver canada used multivariable generalized estimating equations estimate effect residential eviction detectable examine art adherence mediating variable june may art exposed participants included study among experienced least one period detectable time updated multivariable model eviction independently increased odds detectable among homeless adjusted odds ratio aor confidence interval well homeless aor post eviction results mediation analyses suggest association mediated incomplete art adherence findings suggest need development evaluation interventions prevent evictions promote art adherence among pwud facing eviction
bayesianism fast becoming dominant paradigm archaeological chronology construction paradigm shift brought large part widespread access tailored computer software provides users powerful tools complex statistical inference little need learn statistical modelling computer programming result run risk software reduced status black boxes would dangerous position community since good principled use bayesian methods requires mindfulness selecting initial model defining prior information checking reliability sensitivity software runs interpreting results obtained article provide users brief review nature care required offer comments suggestions help ensure community continues respected philosophically rigorous scientific approach
high speed permanent magnet machines supplied pulsewidth modulation pwm voltage source inverters operate distorted stator currents harmonics present stator currents deteriorate machine performance generating losses mostly losses following machine design using transient finite element model precise measurement rotor eddy current losses extremely difficult hence papers provide convincing comparisons predictions measurements paper presents fast precise analytical approach verified measurements consider rotor losses machines supplied pwm voltages already design procedure
objectivedesire thinking voluntary cognitive process involving verbal imaginal elaboration desired target recent research revealed desire thinking may play significant role escalation craving goal study explore effect desire thinking induction craving sample patients alcohol use disorder methodsten patients alcohol use disorder exposed brief exposure alcohol related thoughts plus desire thinking induction versus brief exposure alcohol related thoughts plus distraction resultsthe induction desire thinking led significant increase distress urge use alcohol compared behavioural assessment test distraction task clinical implications treatment alcohol use disorder discussed copyright john wiley sons ltd
global warming climate change increased frequency heavy precipitation heavy rainfall results large amount water entering roadways within short time period water remains pavement system certain time period reduces strengths moduli granular bases subgrades induces pavement distresses geotextiles commonly used roadways drainage purposes require soil saturation however soil saturation always exist roadways enable gravity drainage water conventional geotextiles wicking geotextile new type woven geotextile recently introduced market remove moisture unsaturated soils wicking geotextile includes special hydrophilic hygroscopic deep groove fibers multichannel cross sections induce high capillary force wick water moist soil without saturation soil ability rate geotextile remove water moist soil depends several factors including temperature relative humidity study series laboratory tests controlled temperature relative humidity conducted quantify water removal rate wicking geotextile half length wicking geotextile submerged water tanks half hung outside tanks water wicked tank geotextile evaporated air tests conducted different test conditions different temperatures relative humidities test results demonstrated wicking geotextile could remove water water tank certain rate three commonly used methods available literature adopted quantify water removal rate wicking geotextile based vapor pressure temperature relative humidity new concept equivalent water evaporation length wicking geotextile proposed study pointed tests presented paper aimed determine maximum water removal capacity geotextile given sufficient water supply american society civil engineers
anal squamous cell carcinoma ascc rare accounting gastrointestinal malignancies sought better understand management strategies ascc setting crohn disease retrospective chart review conducted using icd codes ascc adult patients diagnosis time ascc diagnosis included seven patients five female included median age years majority presented perianal pain three bleeding four mean duration years five patients active perianal fistulizing disease time ascc diagnosis clinical stage diagnosis ascc stage stage stage stage iii stage unknown patients treated radiation chemotherapy three patients experienced complications radiation therapy fistulizing disease stenotic disease flap necrosis two patients persistent disease months one patient underwent abdominoperineal resection apr chemotherapy radiation two patients developed locally residual metastatic disease died within year diagnosis five year disease free survival standard nigro protocol remains standard care patients ascc setting patients may best approached case case basis may even require operation first due complications radiation aggressive nature disease due poor treatment outcomes surveillance guidelines patient population necessary
primary rotating flow prf secondary rotating stream srs two basic rotating flow patterns compared mixing performances via iodine transfer process cci water mixing power consumptions srs mixer prf blender approximated maximum value alpha srs exceeded alpha bar srs higher alpha bar prf orders magnitude total energy consumption srs mixer lower prf blender orders magnitude also found alpha bar srs increased sharply decrease consistent typical characteristics higee technology furthermore computational fluid dynamics cfd applied simulate pressure flow field distributions srs based analysis velocity distribution mappings concluded srs spontaneously generates intensive convection vigorous shear stress reversing high gravity field curve alpha srs versus semi circle channels composed peak line wave line theory systematically illustrated reasons high efficiency srs four perspectives time mixing thermodynamics momentum mass transfers opposite energy flows many advantages potentials srs widely explored applied chemical engineering field elsevier rights reserved srs
future population settle large cities metropolitan areas basins pressure water resources already large situation operators water sanitation services must make continuous effort planning reach effective application reduced natural economic resources however urban water systems composed many different elements interact exhibiting feedback loops emerging behaviors simple models could used short complex systems conditions decision makers require appropriate methods tools allow examine several alternatives impacts time systems approach adaptive dynamic modeling one active promising research fields water resources management paper use dynamic modeling applied supply water cities proposed general model shown applied city puebla metropolitan area trend balance scenarios analyzed second composed group conservation rainwater harvesting reuse actions years horizon demonstrating possibility leading system deficit surplus water exemplifying benefits dynamic modeling urban water systems
tinea pedis onychomycosis often occur individuals relationship swimming pools tinea pedis exists however little research investigated relationship onychomycosis tinea pedis swimming pools study sought examine prevalence tinea pedis onychomycosis among swimming pool employees population may risk tinea infections samples taken employees swimming pools netanya area israel koh microscopy culture used identify fungi swimming pool employees concurrent tinea pedis onychomycosis tinea pedis onychomycosis compared controls respectively adjusting age gender swimming pool employees likely concurrent tinea pedis onychomycosis likely tinea pedis likely onychomycosis compared controls present results agreement previous research support swimming pools remain important source fungal contamination attention hygienic guidelines preventative measures may needed settings
pyroclastic density currents pdcs lethal threat volcanoes two main types pdcs fully turbulent fully dilute pyroclastic surges concentrated pyroclastic flows encompassing non turbulent turbulent transport pyroclastic flows subject present study far complex dilute pyroclastic surges remain least understood type despite far greater hazard greater runout length ability transport vast quantities material across earth surface present large scale experiments natural volcanic material gas order provide missing quantitative view internal structure gas particle transport mechanisms pyroclastic flows show outer flow structure head body wake regions broadly resembles current pdc analogues dilute gravity currents however internal structure lower levels consist concentrated granular fluid upper levels dilute contrasts significantly internal structure fully dilute gravity currents bipartite vertical structure shows strong analogy current conceptual models high density turbidity currents responsible distribution coarse sediment marine basins great interest hydrocarbon industry lower concentrated non turbulent levels pdc granular fluid basal flow act fast flowing carrier dilute turbulent upper levels current ash cloud surge strong kinematic coupling flow parts reduces viscous dissipation entrainment ambient air lower part ash cloud surge leads state forced super criticality whereby fast destructive pdcs endure even large distances volcanoes importantly basal flow ash cloud surge coupling yields characteristically smooth rheological boundary across non turbulent turbulent interface well vertical velocity density profiles ash cloud surge strongly differ current theoretical predictions observed generation successive pulses high dynamic pressure within upper dilute levels pdc may important understand destructive potential pdcs experiments show wide range degree coupling particle gas phases critical vertical longitudinal segregation currents reaches starkly contrasting sediment transport capacities particular formation mesoscale turbulence clusters strong particle gas feedback controls vertical stratification inside turbulent upper levels current ash cloud surge triggers significant transfers mass momentum ash cloud surge onto granular fluid basal flow results open new pathways advance current computational pdc hazard models describe interpret pdcs well types high density gravity currents transported across surfaces earth planets across marine basins elsevier rights reserved
japan rapidly aging populace accompanying demographic social economic problems forcing gradual opening increased immigration paper consequently considers factors influence public opinion toward immigration japan using multilevel statistical modeling test hypotheses regarding economic threat cultural threat contact salience change
ionic polymer metal composite ipmc novel smart material widely implemented mems biomimetic mechanical electrical integrated system micro operation system ipmc different shapes dimensions implemented many different types biomechanical integrated systems one inherent properties called creep characteristic difficult handled limits application different ipmcs integrated systems promising control method called sliding mode control smc proposed resist creep characteristics paper smc controller regulate ipmc actuators different shapes dimensions effectively resist creep characteristics without changing parameters control system experiments four different types ipmc actuators conducted semi physical smc experimental platform experimental results confirm feasibility smc control approach regulating multi ipmcs different shapes dimensions based integrated system
preamplifier based source follower direct injection sfdi topology use read integrated circuits roic quantum well infrared photodetectors focal plane arrays qwip fpa demonstrated fabricated circuit shows high linearity high integration time hundreds low current detection capabilities wide range input current order performance achieved use poly poly capacitor although presenting penalties area consumption provides higher linearity lower leakage current higher temperature stability others capacitors found literature secondary effects charge injection clock feed observed experimental results classical techniques like use dummy transistor shown effective minimizing effects maximizing linearity response overall results indicate circuit architecture great potential practically integrated larger qwip fpa roics showing improved performance relating previous works literature
overselective stimulus control refers discriminative control number controlling stimuli limited effective behavior experiment included special education students exhibited overselective stimulus control two sample delayed matching task intervention added compound identity matching opportunity within sample observation period matching trials compound matching functioned differential observing response dor high accuracy verified observation discrimination sample stimuli nineteen participants learned perform dor two sample delayed matching accuracy increased substantially dor completely withdrawn sessions accuracy declined experiment gradual withdrawal dor requirements showed highly accurate performance could maintained dor proportion trials participants results show dor training may lead general improvement observing behavior
irrigation projects realized turkey completely financed state internal funds foreign credits private construction companies deliver projects management state hydraulic works state foundation responsible managing country water resources decisions related irrigation projects turkey important effect agricultural development high amounts allocated national budget implementation exploring best design among various alternatives design development stage serious challenging process determines course success level irrigation projects regard case study introduces risk assessment procedure experienced state hydraulic works design development stage determine best design alternative irrigation project furthermore case study includes crucial remarks another project construction neither state hydraulic works contractor company far executed risk assessment useful decisions taken associated design alternatives former project various problems occurred latter one construction applying risk assessment design development stage
research asian americans experiences racism examined impact generation status ethnicity study investigates phenotypic physical appearance characteristics implicated self reports racialization social anxiety asian american college students completed measures psychological distress well racialization subtle blatant racism scale yoo steger lee participants digital photographs analyzed test whether specific physical characteristics correlated self reported distress results suggest eyeglasses darker skin tone strongly associated greater reports racialization psychological distress asian american college students
art historian ernst gombrich asserted artists viewers constrained specific cultural mental sets within operate used schemata refer actual sketches mental sets mapping mechanism culture juri lotman situated language schematized image centre semiospheres function introduce unity eliminate contradictions schemata obviously served cause result human knowledge loosely constructed yet highly condensed forms art different domains theorizing time hypertrophy scientific linguistic models lotman gombrich appear converged theorizing means connecting people across cultures put forward perspectives concerning interplay culture art pictorial representation paper serves examine lotman gombrich interpreted jakobson scheme communication reveal paradox schemata nonverbal communication latent writings soften paradox drawing lotman conceptulization play emotional structure argued kind emotive potential defined perspective beholders addressees crucial survival global village
effect concentration viscoelastic properties chestnut acorn starch discussed paper starch structure assessed using rheological fractional standard linear solid model fslsm contrary simple power law model usually used many published papers concerning determination rheological properties starch rheological parameters model determined changes different concentrations two tested types starch discussed values rheological parameter fslsm model give useful information concerning elastic properties materials total elasticity networks network oscillations gel stiffness structure cross linking relaxation time materials proposed method interpretation rheological measurements two types starch allows comprehensive estimation analyzed biomaterial structure fractional rheological models useful control biomaterial structure needs final meet envisaged product particularly significant point view materials engineering
paper presents numerical model computing electromagnetic forces existing large hydro generator hydro quebec due high mass low rotational speed hydro generators present static dynamic combined eccentricities resulting unbalanced magnetic pull air gap unbalanced stator currents caused variation magnetic flux density distribution model uses advanced numerical finite element analysis compute electromagnetic forces based maxwell stress tensor obtained results used later inputs study dynamic behavior hydro power turbine shaft results obtained electromagnetic forces damper bar currents circuit currents due magnetic unbalance presented discussed detail
even small design work designers always try design product integration techniques asethetics applicability emotion functions ornamentation scientific artistic combination take mechanics materials design account mechanics remain internal theory textbooks materials remain data database solely art also represents unrestrained imagination artists three articles bring new experience inspiration
big data widely recognized one powerful drivers promote productivity improve efficiency support innovation highly expected explore power big data turn big data big values answer interesting question whether inherent correlations two tendencies big data green challenges recent study investigated issues greening whole life cycle big data systems paper would like discover relations trend big data era new generation green revolution comprehensive panoramic literature survey big data technologies toward various green objectives discussion relevant challenges future directions
purpose reviewfunctional dizziness new term somatoform psychogenic dizziness aim study review arguments new nomenclature clinical features possible pathomechanisms comorbidities functional dizziness recent findingsthe prevalence functional dizziness primary cause vestibular symptoms amounts neuro otology centers rates psychiatric comorbidity patients structural vestibular syndromes much higher nearly highest rates patients vestibular migraine vestibular paroxysmia meniere disease pathophysiologic processes seem include precipitating events trigger anxiety related changes postural strategies increased attention head body motion cocontraction leg muscles personality traits high levels neuroticism low levels extraversion appear risk factors anxiety depressive disorders increased morbidity functional disorders summarycorrect early diagnosis functional dizziness primary cause secondary disorder structural vestibular syndrome important prevent chronification enable adequate treatment treatment plans include patient education vestibular rehabilitation cognitive behavioral therapies medications substantially reduce morbidity offer potential sustained remission applied systematically
background depression growing health issue developed developing countries general unawareness population level lack training among health care providers scarcity resources including treatment opportunities may conceal real burden depression developing countries epidemiological studies prevalence risk factors critically needed aim study reports prevalence depression associated risk factors among female garment factory workers bangladesh major supplier country clothes western market research generate useful evidence national international stakeholders interest improving health safety well outsourced factory workers methods survey conducted sample lower socio economic status working women including garment workers survey collected data demographic health profile workers primary outcome depression measured patient health questionnaire also obtained data traumatic life events post traumatic stress disorder results prevalence depression among garment workers among others part time employment odds ratio confidence interval chronic pain two traumatic life events dysuria found significantly associated depression among workers multivariate regression model depression prevalene lowered among workers every additional monthly earning taka conclusion depression multifaceted health issue many personal social economic health determinants consequences study demonstrates prevalence moderate severe depression among working women bangladesh quite high prevention treatment depression developing countries societies reduce suffering lower incidence suicide prevent economic loss creating awareness outsourced workers poor mental health may help developing initiatives protect preserve well
background prevalence smoking patients schizophrenia higher general population important medical issue short term smoking cessation tends worsen psychiatric symptoms patients schizophrenia decreases sympathetic nervous system activity improves plasma cholesterol levels healthy people studies assessed long term effects smoking cessation patients schizophrenia methods subjects japanese patients schizophrenia smokers non smokers compared following clinical parameters two groups baseline smoking cessation group separately baseline three years smoking cessation autonomic nervous system activity plasma cholesterol levels body weight drug therapy global assessment functioning scores also compared mean changes clinical parameters throughout study groups time points autonomic nervous system activity assessed power spectral analysis heart rate variability results parasympathetic nervous system activity doses antiparkinsonian drugs smokers significantly higher non smokers baseline smoking cessation associated significantly decreased sympathetic nervous system activity decreased doses antipsychotics antiparkinsonian drugs three years smoking cessation however significant difference mean change clinical factors scores except global assessment functioning scores smokers non smokers three years smoking cessation conclusions results suggest smoking reduces autonomic nervous system activity effectiveness drug therapy antipsychotics antiparkinsonian drugs patients schizophrenia factors could ameliorated long term smoking cessation taken together findings previous studies smoking cessation patients schizophrenia many long term positive physiological effects
objective compare bladder sensitivity patients pelvic pain patients pain free undergoing noninvasive controlled bladder distension via diuresis also sought measure potential mechanisms underlying bladder sensitivity design prospective observational study setting community teaching hospital population reproductive age women non bladder chronic pelvic pain cpp painful bladder syndrome pbs pelvic pain free controls methods participants compared cystometric capacity pelvic floor pressure pain thresholds ppts pelvic muscle function leary sant bladder questionnaire psychosocial instruments using wilcoxon rank sum tests multivariate regression used identify factors underlying bladder pain phenotypes main outcome measures pelvic floor pain thresholds self reported bladder distension pain results participants pbs exhibited higher bladder distension pain cpp groups reporting higher pain levels controls significant associations found bladder distension pain pelvic muscle structure pain sensitivity measures however bladder distension pain positively correlates vaginal ppts adjacent bladder pain transvaginal bladder palpation pain maximal distension less influenced somatic sensitivity bladder symptoms versus multivariate regression identified three independent components bladder symptoms pbs bladder distension pain bladder sensation somatic symptoms conclusions diuresis induced bladder pain differentiates cpp pbs experimental bladder pain predicted pelvic floor sensitivity compared patient reported outcomes appears less influenced psychological factors study needed determine whether screening experimental bladder pain sensitivity could predict future risk pbs
operational transconductane amplifier ota fundamental building block analog signal processing application paper demonstrates wide linear range low voltage subthreshold mode based fully differential ota using bulk driven technique proposed ota linearly tunable feature low distortion high output impedance open loop gain ota enhanced use improved wilson current mirror ota provides increase linearity volt open loop gain enhanced unity gain bandwidth ugb khz proposed ota operates volts power consumption ota remains range hundreds nanowatts ota analysis performed standard tsmc micrometer technology bsim model using eldo spice simulator
community acquired acute kidney injury aki found common event population current incidence estimates available evaluations severe elevations serum creatinine indicate incidence high cases per million population older years data risk factors limited older age higher comorbid illness burden especially diabetes cardiovascular disease seem common patients suffer aki addition common hospital acquired aki long term sequelae aki seem severe including renal disease progression mortality efforts better understand aetiology aki ultimately prevent development condition need taken meantime concerted effort general internists nephrologists needed prevent aki highest risk patients thus limit poor outcomes associated entity summary glance review authors show community acquired acute kidney injury common severe important long term adverse consequences
introduction last years ketogenic diet experimentally utilized various childhood neurologic disorders mitochondriopathies alternating hemiplegia childhood ahc brain tumors migraine autism spectrum disorder asd aim review analyze target different medical conditions highlighting possible mechanisms involved areas covered conducted analysis literature concerning use mitochondriopathies ahc brain tumors migraine asd expert commentary role reducing seizure activity mitochondriopathies efficacy pyruvate dehydrogenase deficiency known recently cases suggest potentiality decreasing paroxysmal activity children affected ahc data support potential use adjuvant alternative therapeutic option brain cancer beneficial effect migraine remains unclear could improve cognitive social skills subset children asd
using restricted data california health interview surveys research illuminates role legal status health care among mexican origin children first objective provide population level overview trends health care access utilization along legal statuses parents children second objective examine nature associations children health care legal status time identify specific status based distinctions matter investigate importance changing despite continuing significance child nativity health care descriptive analysis shows proportion mexican origin children foreign born declining trend suggests potentially greater role parental legal status children health care logistic regression analyses demonstrate importance parental legal status varies health care indicator examined inclusion child nativity models moreover variation aspects children health care coalesced around parents citizenship documentation status past one exception salience distinctions dissipated time
apelin newly discovered peptide serum level increases diabetic patients cardiovascular dysfunction recent studies indicate beneficial actions betaine reducing cardiovascular metabolic complications however data related effect adipocytokine expression limited aim study evaluate effect betaine supplementation apelin gene expression cardiac muscle adipose tissue insulin resistance diabetic rats fed high calorie diet induce insulin resistance rats fed high fat high carbohydrate diet five weeks stz injected intraperitoneally confirming diabetes incidence serum glucose mmol animals treated betaine drinking water days days treatment animals euthanized apelin gene expression evaluated real time pcr western blot heart adipose tissues serum levels insulin apelin glucose homa also measured results showed feeding rats high calorie diets caused insulin resistance manifested elevated plasma insulin glucose apelin levels also homa apelin gene expression heart adipose tissues significantly increased simultaneously progression diabetes betaine supplementation decreased serum apelin regulated apelin expression adipose tissue cardiac muscle particularly day treatment concluded betaine might improve metabolic cardiovascular complications diabetic patients regulation apelin expression secretion
real time rendering high precision shadows using digital terrain models input data challenging task especially interactivity targeted level detail data structures utilized tackle huge amount data paper present real time rendering approach computation hard shadows using large scale digital terrain data obtained satellite imagery approach based extended horizon mapping algorithm avoids costly pre computations ensures high accuracy algorithm developed handle large data proposed algorithms take surface curvature large spherical bodies account computation performance issues discussed results presented generated images exploited research aerospace related areas graphics
higher education traditional forms teaching management system difficult adapt individualized requirements cultivation personalized talents higher education information technology new trend world plays important role promoting universities personalized education innovation training personnel improving integrated use excellent teaching resources deepening teaching management reform improving teaching management level enhancing teaching quality advanced manufacturing engineering colleges universities attach great importance building information quality teaching environment information technology promote information technology education major manufacturing engineering
action recognition aiming automatically classify actions series observations attracted attention computer vision community state art action recognition methods utilize dense sampled trajectories build feature representations however performances limited due action region clutters camera motions real world applications matter scenario changes different backgrounds salient cues actions highly dependent appearances motions based discovery paper propose novel saliency based dense sampling strategy named improved dense trajectories idt salient region based contrast boundary idt rcb without external human detector robust mask generated overcome limitations global contrast based saliency action sequences warped optical flow exploited adjust interest points sampling remove subtle motions show appropriate pruning feature points achieve good balance saliency density sampled points experiments conducted three benchmark datasets demonstrated effectiveness proposed method specifically fusion deep learned features hand crafted features even improve recognition performance baseline dense sampling methods particular fusion scheme achieves state art accuracy hollywood ucf respectively
antimicrobial peptides amps cuticular extracts worker ants trichomyrmex criniceps mayr hymenoptera formicidae isolated evaluated antimicrobial activity eight peptides ranging mass characterized using combination analytical bioinformatics approach eight peptides novel similarity amps archived antimicrobial peptide database two eight novel peptides smallest largest mass named crinicepsin crinicepsin chemically synthesized solid phase peptide synthesis two synthetic peptides antibacterial weak hemolytic activity
consumption high fat diet hfd overweight induce functional deterioration atrophy hippocampus alterations associated mental disorders depression anxiety exercise combats obesity enhances brain health substantial evidence neuronal nitric oxide synthase nnos key regulator affective behavior increased brain nnos leads anxiety environmental enrichment reduces brain nnos anxiolytic effects study investigated effects hfd without exercise nnos protein gene expression levels brains mice twelve weeks hfd consumption increased body mesenteric fat weight well nnos protein levels hippocampus cerebral cortex six weeks exercise training reduced body fat rescued hippocampal cortical nnos expression levels hfd fed mice cerebellar nnos expression unaffected hfd exercise results suggest hfd induced brain dysfunction may regulated hippocampal cortical nnos exercise may therapeutic potential treatment hfd induced depression anxiety via nnos pathway conclusion exercise reverses hfd induced changes hippocampal cortical nnos protein levels mice elsevier inc rights reserved
laparoscopic roux gastric bypass lrygb laparoscopic vertical sleeve gastrectomy lvsg proposed cost effective strategies manage obesity related chronic disease aim systematic review study peer review literature regarding postoperative nondiabetic comorbid disease resolution improvement reported randomized controlled trials rcts comparing lvsg lrygb procedures rcts comparing postoperative comorbid disease resolution hypertension dyslipidemia obstructive sleep apnea joint musculoskeletal conditions gastroesophageal reflux disease menstrual irregularities following lvsg lrygb included analysis studies selected pubmed medline embase science citation index current contents cochrane database reported least one comorbidity resolution improvement present work undertaken according preferred reporting items systematic reviews meta analyses prisma jadad method assessment methodological quality applied included studies six rcts performed involving total patients lvsg lrygb reported resolution improvement comorbid disease following lvsg lrygb procedures bariatric procedures provide effective almost comparable results improving resolving comorbidities systematic review rcts suggests lvsg lrygb effective resolving improving preoperative nondiabetic comorbid diseases obese patients results conclusive time lrygb may provide superior results compared lvsg mediating remission improvement conditions dyslipidemia arthritis
grinding mill performance typically controlled making operating adjustments taking external measurements infer happening inside mill optimising existing machines designing new ones difficult expensive dem offers broad range capabilities look inside mills gain improved understanding charge dynamics prediction power draw knowledge energy utilisation paper demonstrate capabilities dem machine design exploring performance variations hicom mill changing operating conditions fill level mill speed different material properties particle size density friction predictions compare well existing experimental observations provide new insights flow dynamics inside hicom mill together demonstrate dem method used mill optimisation design process crown copyright published elsevier rights reserved
optimal sustainable public transport infrastructure project portfolio selection requires environment management strategy social economic development study considers application multi criteria decision making mcdm methodology applied assess sustainable development transport infrastructure projects taking account range transport social financial environmental criteria furthermore order resolve strategic decision making resource constraints carbon footprint factor zero one goal programming zogp model developed facilitate optimal portfolio sustainable public transport infrastructure projects taiwan resulting data shows perspective sustaihable transport criterion decreasing traffic energy consumption significant evaluation factors tamhai light rail tlr project tambai expressway project comprise far optimal portfolio sustainable transport infrastructure projects strengthen connection activity based costing abc evaluation carbon footprint life cycle assessment integrated approach practical useful tool providing solution related information sustainable public transport infrastructure projects help managers incorporate environment costs decision making processes elsevier ltd rights reserved
transparency associated single second mode frequency band gap caused orthogonality breaking induced multimode interactions investigated polarized terahertz waveguide arbitrary wall profile found pure single mode penetrate bragg gap originating lower mode resonances propose method achieving bandwidth agile transparency periodic cylindrical waveguide means suitable wall profile perturbation theory respect wall corrugation amplitude reveals underlying physics single mode transparency major fourier component wall profile affects width stopband proportionally whereas transparent passband within stopband varies inverse proportion numerical simulations four different types wall profile confirm width transparent band manipulated proposed fourier components present simulations demonstrate small variation frequency band structure around thz indicating validity proposed method extensive investigations single mode transparency provide significant benefits future mode control engineering terahertz devices
criminal justice involved clients often complicated population students consider lens oppression nevertheless critical given many serve clients criminal records careers attempt challenge students prejudice toward criminal justiceinvolved people deployed using teaching technique derived intergroup contact theory authors invited juan melendez share story incarceration death row years crime commit article examination impact melendez story application intergroup contact theory
obesity women increased loss circulating estrogen menopause shift work disrupts circadian rhythms also increases risk obesity known whether ovarian hormones interact circadian system protect females obesity high fat feeding male cbl mice develop profound obesity disruption daily rhythms since cbl female mice develop diet induced obesity weeks high fat feeding first determined daily rhythms female mice resistant disruption high fat diet fed female period luciferase mice high fat diet week measured daily rhythms female mice retained robust rhythms eating behavior locomotor activity high fat feeding similar chow fed females addition phase liver molecular timekeeping per luc rhythm altered high fat feeding females determine ovarian hormones protected daily rhythms female mice high fat feeding analyzed rhythms ovariectomized mice high fat feeding amplitudes eating behavior locomotor activity rhythms reduced ovariectomized females liver per luc rhythms also advanced similar high fat feeding chow ovariectomized females together data show circulating ovarian hormones protect integrity daily rhythms female mice high fat feeding
background role environmental exposures pathogenesis ankylosing spondylitis remains unclear particular two types exposures suspected play role mechanical stress infections objective case control study determine childhood infections associated later development methods cases identified swedish national outpatient specialised care register based given least one diagnosis register five controls per case identified swedish population register matched time point index case first spondyloarthritis diagnosis sex birth year county cases controls matched prior age years excluded well cases controls given diagnosis reactive arthritis juvenile arthritis time point diagnosis rheumatic disease psoriasis iridocyclitis inflammatory bowel disease time point matching events hospitalisation infection age years retrieved register categorised according focus infection odds ratios ors confidence intervals cis determined conditional logistic regression analyses results cases controls cases controls hospitalised infection age years appendicitis cases controls respiratory tract infections cases controls particular tonsillitis cases controls associated associations type infection point estimates similar several sensitivity analyses conclusions childhood appendicitis associated decreased risk whereas respiratory tract infections associated increased risk later development findings support possible relationship childhood infections later development although study limited infections resulting inpatient care
purpose develop mechanistic mathematical model predicting pharmacokinetics topically applied solutes penetrating skin blood circulation model could used support design transdermal drug delivery systems skin care products risk assessment occupational consumer exposure recently reported skin penetration model pharm res integrated kinetic equations dermis capillary transport systemic circulation model parameters determined separately molecular microscopic physiological bases without fitting vivo data predicted published clinical studies nicotine used model demonstration predicted plasma kinetics good agreement observed clinical data simulated two dimensional concentration profile stratum corneum vividly illustrates local sub cellular disposition kinetics including tortuous lipid pathway diffusion reservoir effect corneocytes mechanistic model predicting transdermal systemic kinetics developed demonstrated published clinical data integrated mechanistic approach significantly extended applicability recently reported microscopic skin penetration model providing prediction solute concentration blood
diagnostic statistical manual mental disorders dsm classification antisocial personality disorder aspd describes individuals engage repetitive irresponsible delinquent criminal behavior diagnosis highly controversial many researchers clinicians arguing category heterogeneous overinclusive demonstrates considerable overlap disorders review focuses recent studies improved understanding characteristics individuals fit aspd definition exploring subtypes differ comorbid conditions influence presentation aspd addition discuss research etiology aspd identified genetic environmental factors may contribute development persistence antisocial behavior brain imaging research improved understanding relationships aspd psychopathology finally discuss promising preliminary research treatment disorder
study new state space representation protein folding problem use reinforcement learning methods proposed existing studies way defining state action space prevents agent learn state space amino acid sequence rather defined state action space valid particular amino acid sequence moreover existing methods size state space strictly depends amino acid sequence length newly proposed state action space reduces dependency allows agent find optimal fold sequence certain length additionally utilizing ant based reinforcement learning algorithm ant algorithm optimum fold protein found rapidly compared standard learning algorithm experiments showed new state action space ant based reinforcement learning method much suited protein folding problem two dimensional lattice model elsevier rights reserved
group ownership ubiquitous property owned countries corporations families clubs however people understand group ownership simply relying conceptions ownership individuals group ownership subject complexities arise property individually owned report experiments investigating whether children ages understand group ownership experiments children asked different objects belong appropriately judged certain objects likely belong group individual people experiments investigated whether children understand limits group ownership children saw vignettes agents modified depleted property children ages older understood individual members group deplete group owned property children ages understood individual members modify group owned property finally experiments investigated whether children understand benefits group ownership children ages judged acceptable group member take group property nonmember children ages judged group members take group resources nonmembers together results informative children conceive group ownership rights children conceptions groups
oscillation test methodology otm effective detecting physical defects open shorts bridging defects low voltage cmos vlsi analog mixed signal circuits paper discusses otm low voltage two stage operational amplifier using well cmos technology high fault coverage minimum area overhead five bridging faults one open fault detected discrete practical realizations extensive simulations based cmos technology parameters using pspice affirm test technique presented mosfet circuits ensures high fault coverage requires negligible area overhead
background treatment omalizumab shown positive effect food allergies dosages established basophil allergen threshold sensitivity sens used objectively measure omalizumab treatment efficacy correlates outcome double blind placebo controlled food challenge peanut objective evaluate whether individualized omalizumab treatment monitored sens could effective intervention suppression allergic reactions peanut methods severely peanut allergic adolescents treated omalizumab weeks sens analysed based whether sens suppressed weeks patients either subject peanut challenge received eight weeks increased dose omalizumab followed peanut challenge another week cycle omalizumab ige ige antibodies peanut components analysed treatment results individualized omalizumab treatment weeks patients continued open peanut challenge mild objective allergic symptoms patients needing elevated omalizumab dose suppress sens significantly higher sens values baseline compared managed normal dose median ratios ara ige ige significantly higher group compared group conclusions clinical relevance individually dosed omalizumab monitored sens effective safe treatment severe peanut allergy ratio ige storage protein ara ige well sens peanut may predict need higher omalizumab dose
paper presents new non invasive technique granulometric analysis based fusion two imaging techniques unmanned aerial vehicles uav based photogrammetry optical digital granulometry newly proposed technique produces seamless coverage study site order analyze granulometric properties alluvium observe spatiotemporal changes proposed technique tested observing changes along point bar mid latitude mountain stream uav photogrammetry acquired low level flight altitude height used acquire ultra high resolution orthoimages build high precision digital terrain models dtms orthoimages covered regular virtual grid granulometric properties grid fields analyzed using digital optical granulometric tool basegrain tested framework demonstrates applicability proposed method granulometric analysis yields accuracy comparable traditional field optical granulometry seamless nature method enables researchers study spatial distribution granulometric properties across multiple study sites well analyze multitemporal changes using repeated imaging
temperature one many important environmental variables impact long term performance strength deformation characteristics many man made construction materials including geosynthetics functional engineering properties materials must remain within acceptable limits service life ensure overall design performance acceptable case geosynthetics used landfills applications laboratory interface shear tests performed standard test conditions including temperature information emerging today shows geosynthetic interfaces landfill liner applications experience elevated temperatures resulting exothermic reactions occurring waste body amongst factors end field conditions elevated temperatures also simulated laboratory physical mechanical laboratory tests order researchers better understand situ functional engineering properties operational performance manmade geo construction materials purpose temperature controlled chamber designed developed allow shear behavior geosynthetic geosynthetic soil geosynthetic interfaces evaluated different temperatures paper describes development validation test system results experimental investigations presented illustrate shear behavior interfaces nonwoven polypropylene geotextile smooth textured high density polyethylene geomembrane well rounded angular sand geomembranes change temperature results provide insight importance able independently control variable mechanical testing laboratory
aims determine value sehcat retention determining bile acid diarrhoea bad treatment response predictors positive result methods retrospective casenote review consecutive patients undergoing sehcat including gender age history clinical laboratory parameters included diseases associated type bad ileal resection crohn disease type bad chi squared test logistic regression determined factors predictive bad subjective response treatment bile acid sequestrants bas analysed respect sehcat result results patients male average age years ninety five patients investigated type bad type patients type idiopathic bad large increase number performed time difference percentage positive tests one hundred seventy nine patients bad positive result commonest possible type severe bad ninety nine patients severe bad sehcat retention moderate bad retention mild bad retention predictors positive sehcat right hemicolectomy cholecystectomy crohn positive sehcat predicted good partial response bas mild moderate severe bad conclusion sehcat test use increased high positive results throughout ileal resection crohn cholecystectomy independently predict bad sehcat predicted response bas
current usage term hybrid electric power referring electrical networks installed offshore marine assets refers coupling energy transformation systems ets utilize different technologies exchange energy electrical network ets composed energy transformation device etd necessary energy converter utilized match electrical characteristics etd electrical network converter facilitates exchange energy etd electrical network required rate ets may also known source capable supplying net positive energy electrical network consumption loads energy exchange electrical network etd may unidirectional directional directional energy exchange implies etd energy absorption capability energy absorption manifest economically energy storage capability alternately may manifest ability dissipate energy ets energy storage capability may operate directionally unidirectional ets include traditional generators utilizing combustion based diesel engine gas turbine boiler steam turbine prime movers well alternate ets fuel cells primary batteries also energy storage capability unidirectional ets wind turbine generators solar energy energy storage capability commonly understand directional etd include secondary batteries capacitors flywheels hybrid electric power systems offer opportunity improve safety reliability operational efficiency reduce fuel rate environmental footprint maintenance costs compared traditional electrical power systems
one reliable technologies network intrusion detection system nids allows monitoring incoming outgoing traffic identify unauthorised usage mishandling attackers computer network systems extent paper investigates experimental performance snort based nids nids practical network latest technology various network scenarios including high data speed heavy traffic large packet size effective testbed designed based snort using different muti core processors different operating systems windows windows server linux furthermore considering enterprise network consisting multiple virtual local area networks vlans centralised parallel nids cps nids proposed support centralised database server deal high data speed heavy traffic experimental evaluation carried network configuration evaluate performance nids different network scenarios well validating effectiveness proposed cps nids particular analysing packet analysis efficiency improved performance shown achieved linux operating systems improved performance achieved processors
objectives fecal occult blood testing fobt performed routinely starting therapeutic anticoagulation patients despite never validated predict gastrointestinal bleeding gib risk objective determine utility checking guaiac fobt test gfobt initiating therapeutic anticoagulation patients new diagnosis venous thromboembolism vte methods retrospective chart review examined patients diagnosis vte admitted year period one mid sized tertiary care center gfobt performed initiating anticoagulation excluding patients overt gib analysis performed determine gib outcomes addition demographics laboratory data comorbidities recorded time admission admission hypertension abnormal renal liver function stroke history gib history predisposition labile international normalization ratio elderly drugs alcohol concomitantly bled score recorded determine factors predictive new onset gib starting anticoagulation results initially patients new diagnosis vte screened years ultimately patients prescribed anticoagulation therapy documented gfobt gib episode positive gfobt present admission bled admission significantly predicted gib admission well median gib without gib conclusions despite beneficial negative predictive value gfobt initiating therapeutic anticoagulation unlikely change management patients without evidence overt gib
paper presents findings psychometric properties new measure usual severity winter symptomatology commonly found seasonal affective disorder sad seasonality assessment form saf many existing sad related measures focus diagnostic screening include limited range symptoms revisions standard self report depression measures undergone psychometric evaluation saf developed address limitations particular include full range cognitive affective vegetative symptoms dsm criteria depressive episode data came diverse sample students community members recruited winter vegetative changes diagnosed sad patients saf total score well vegetative cognitive affective subscales exhibited good internal consistency convergent construct validity saf demonstrated bifactor structure suggesting large global severity factor additional subfactors related appetite weight negative thought content symptomatic participants reported relatively high levels impairment daily activities particular avoiding delaying daily tasks sum saf appears concise comprehensive reliable valid measure sad symptom severity addition instructions revised easily provide parallel forms assessing current episode recent weeks
individuals understanding wealth power largely determines use resources moreover age range wealth power holders increasing modern societies thus current study examines people different ages understand wealth power varying future time perspective related changes prioritised life goals tested potential mediator age differences total participants aged years asked open ended questions regarding understanding possible use desired use wealth power reported future time perspective compared possible use participants mentioned relatively prosocial elements talked desired use resources especially power older adults expressed prosocial understanding regard desired use wealth possible use power compared younger counterparts age differences fully mediated future time perspective results suggest age critical factor influences individuals conceptualisation wealth power life span developmental stage future time perspective important factors consider explaining individual differences exercise wealth power promoting prosocial usage
light duty vehicles contribute considerably global greenhouse gas emissions fuel cell vehicles fcvs may play key role mitigating emissions without facing limitations range refueling time battery electric vehicles bevs study assess environmental impacts costs polymer electrolyte membrane fuel cell system fcs use light duty fcvs integrate results comparative evaluation fcvs bevs internal combustion engine vehicles icevs conduct detailed life cycle assessment lca cost assessment current state technology two future scenarios technological development compile detailed consistent inventory fcs systematically disassembling integrating information found cost studies vehicle level comparison use models ensure vehicle size performance fuel consumption unbiased vehicle types consistent scenarios technological development results show fcvs decrease life cycle greenhouse gas emissions compared gasoline icevs hydrogen produced renewable electricity thus exhibiting similar emission levels bevs charged electricity mix hydrogen produced natural gas reforming fcvs found offer greenhouse gas reductions along higher impacts several environmental impact categories major contributor impacts fcs particular platinum catalyst carbon fiber hydrogen tank large amount carbon fiber used tank also reason found fcvs may become fully cost competitive icevs bevs even substantial technological development mass production components assumed conclude fcvs lead lower greenhouse gas emissions icevs fuel sourced renewable energy case bevs fcvs attractive alternative icevs terms vehicle performance criteria range refueling time however technological challenges associated reducing environmental impacts costs fcvs seem large larger associated capacity costs batteries bevs even taking account efforts required build hydrogen infrastructure network road transportation
advancement world wide web revolutionized way manufacturers business manufacturers collect customer preferences products product features sales product related web sites enter sustain global market example manufactures make intelligent use customer preference data decide products selected targeted marketing however selected products must attract many customers possible increase possibility selling respective competitors paper addresses kind product selection problem given database existing products competitors set company products dataset customer preferences positive integer want find promising products mpp maximum expected number total customers targeted marketing model mpp query propose algorithmic framework processing query variants framework utilizes grid based data partitioning scheme parallel computing techniques realize mpp query effectiveness efficiency framework demonstrated conducting extensive experiments real synthetic datasets
high quality cardiopulmonary resuscitation contributes cardiac arrest survival traditional chest compression standard neglects individual differences uses unified standards compression depth compression rate practice study effective personalized method automatic mechanical compression devices provided rebuild charles babbs human circulation model coronary perfusion pressure cpp simulation module propose closed loop controller based fuzzy control algorithm ccs adjusts depth according cpp compared traditional proportion integration differentiation pid controller performance fuzzy controller evaluated computer simulation studies simulation results demonstrate fuzzy closed loop controller results shorter regulation time fewer oscillations smaller overshoot traditional pid controllers outperforms traditional pid controller cpp regulation maintenance
digital computers automate manufacturing process important aspect manufacturing engineers modern world selection programming paradigm well programming language supports crucial ensure correct ideas used automate solution problem current malaysian higher institution practices various pps pls courses offered current undergraduate manufacturing majors online survey deployed experienced manufacturing engineers various manufacturing specializations industry graduates one malaysia public universities international islamic university malaysia hum chosen particular study survey found almost participants agreed pps important manufacturing graduates found participants intermediate scale poor scale express ability explain pps asked able explain pps scale study concluded majority manufacturing graduates hum agreed important subject taught university however found majority manufacturing graduates lack knowledge understanding pps general pls
organizational life history documents founder elite gymnastics training organization led organizational members resist deemed unethical institutional influences prior working toward changing institutional practices study contributes idea institutional resistance leadership team organizational levels precede disruptive institutional entrepreneurship activities institutional level diachronic analysis describes micro local historical intra organizational work serves proving ground generating resistance proceeding institutional level work article explores leadership activities scaled affect institutions intermediary organization identity violations triggered founder sensemaking moved lead others resist institutional forces organization training practices founder used rhetorical strategy narrative create sensebreaking help members make sense dominant institutional influence articulate alternative philosophy translate alternative practices acquire material resources undertaking resistance local organizational level finally attempting scale institutional entrepreneurship institutional resistance leadership struggled defining success organization view dominant institutional actors
main purpose study measure changes students perception problem solving ability time using rasch measurement model pre experimental one group pretest posttest design conducted investigate web based learning system design education known proud affected students perceptions problem solving ability thirty second year students pursuing bachelor degree technical vocational education participated study respondents utilized proud weeks process learning design problem solving inventory used research instrument appeared valid reliable measure changes pretest administered beginning course posttest learning completed changes students perceptions problem solving ability gauged using rack stack analysis paired sample test also included data analysis result pretest posttest logits logits respectively findings indicate perceptions students ability solve problems increased significantly using proud paired sample test proven use proud changes students perception problem solving ability throughout learning process design
improving yield strength asymmetry critical expand applications magnesium alloys industry higher fuel efficiency lower production grain refinement efficient method strengthening low symmetry magnesium alloys achievable precipitate refinement study provides guidance precipitate engineering improve mechanical properties grain refinement precipitate refinement improving yield strengths asymmetry simulated quantitatively coupling stochastic second phase grain refinement model modified polycrystalline crystal viscoplasticity model using stochastic second phase grain refinement model grain size quantitatively determined precipitate size volume fraction yield strengths yield asymmetry deformation behavior calculated modified model precipitate shape size remain constant grain size decreases increasing precipitate volume fraction precipitate volume fraction kept constant grain size decreases decreasing precipitate size precipitate refinement yield strengths increase asymmetry approves one decreasing grain size contributed increasing precipitate volume fraction decreasing precipitate size
paper reports qualitative study incarcerated indigenous fathers australia using framework generative fathering researchers interviewed imprisoned indigenous men experiences parenting responses parenting programme participants identified programme supported learning capacity embrace role parenting next generation responses indicate programme format content relevant experience indigenous fathers enhanced skills facilitator provision safe learning environment facilitated growth individuals parents acknowledging cultural identity roles
analogical reasoning important mechanism social cognition typically developing children recent evidence suggests forms analogical reasoning may preserved autism spectrum disorder unanswered question whether children autism spectrum disorder apply analogical reasoning social information children autism spectrum disorder completed social content analogical reasoning task presented via photographs real world social interactions autism spectrum disorder participants exhibited performance well chance significantly worse age intelligence quotient matched typically developing children investigating relationship social content analogical reasoning performance age cross sectional dataset indicated similar developmental trajectories autism spectrum disorder typically developing children groups findings provide new support intact analogical reasoning autism spectrum disorder theoretical implications analogy metacognitive skill may least partially dissociable general deficits processing social content initial study social analogical reasoning children autism spectrum disorder study focused basic research question limited ecological validity evidence children autism spectrum disorder apply analogical reasoning ability social content may long range applied implications exploring capacity might channeled improve social cognition daily life
perfect matchings maximum weight matchings two fundamental combinatorial structures consider ratio maximum weight perfect matching maximum weight general matching motivated computer graphics application triangle meshes seek convert triangulation quadrangulation merging pairs adjacent triangles focus mainly bridgeless cubic graphs first characterize graphs attain extreme ratios second present lower bound bridgeless cubic graphs third present upper bounds subclasses bridgeless cubic graphs shown tight additionally present tight bounds class regular bipartite graphs elsevier rights reserved
although percentage patients report cognitive sideeffects taking lithium difficult determine literature whether cognitive changes reflect lithium lithium serum level residual mood symptoms underlying nature bipolar disorder biological alterations hypothyroidism review carried synthesize evaluate relevant literature examining cognitive impact lithium bipolar disorder effect lithium bipolar disorder examined across cognitive domains attention psychomotor speed processing speed working memory intellectual functioning verbal memory visual memory executive functioning reviewing published empirical literature impact hypothyroidism lithium toxicity also examined literature supports conclusion lithium distinct impact psychomotor speed participants bipolar disorder contrast appears impact attention impact lithium memory patients bipolar disorder unclear literature contradictory effect may overshadowed greater impact residual mood symptoms impact processing speed intellectual abilities executive functioning also remains unclear several clinical management strategies recommended copyright wolters kluwer health inc rights reserved
depression highly prevalent mental health problem morbidity mental physical behavioural disorders internet allows individuals depressed caring depressed connect others via online communities however characteristics discussions yet fully explored work aims explore textual cues online communities interested depression total posts randomly selected online communities five subgroups online communities identified depression bipolar disorder self harm grief bereavement suicide psycholinguistic features content topics extracted posts analysed machine learning techniques used discriminate online conversations depression communities subgroups topics psycholinguistic features found highly valid predictors community subgroup clear discrimination linguistic features topics alongside good predictive power important step understanding social media use mental health
fuel cell systems appropriate candidates alternative energy sources use stand alone applications however generates unregulated voltage suitable stand alone application usage solely paper presents control stand alone application based fuzzy pid fpid controller aim paper designing controlling suitable power conditioning unit pcu consists two converter stages inverter addition analysis cascade structure based fuzzy pid controller single phase inverter done also two feedback control loops comprised inductor current capacitor voltage measured sent feedback inner loop outer loop respectively besides evaluate proposed controller robustness pcu considered step loads disturbance finally shown proposed controller robust behavior good transient response elsevier ltd rights reserved
rainwater harvesting rwh increasingly utilized today populations alleviate water supply issues particularly rural dry environments limited research considered simultaneously numerous factors contribute sustainability example social acceptance water quality maintenance needs rwh research aimed improve understanding factors influencing sustainability rainwater harvesting systems domestic use drwhs examination social water quality technical feasibility components conducted household surveys rainwater quality analyses san jose xacxamayo rural semi arid community puebla mexico results showed drwhs socially accepted primarily presence existing local skills knowledge well critical need water results water quality parameters measured within world health organization guidelines human consumption exception total coliform heterotrophic plate count required water treatment prior consumption technical feasibility main barrier sustainability drwhs highly seasonal rainfall small roof sizes averaging resulted households unable meet annual water needs increasing roof sizes providing water treatment could ensure drwhs sustainability studied community
gender ideologies cape verde shifting individuals find caught changing tides pushed pulled opposite directions divergent gendered expectations article examines different ways young women men take recourse tactics response tensions arise deal changing gender ascriptions midst relations community kin women particular unevenly affected traditional demands expectations whilst cross boundaries traditional gender roles pursuit enhanced education sexual freedom yet actions characterized outright rejection traditional gender ideologies rather piecemeal tactical manoeuvres plot route centrifugal forces play
thermal mixed convection flows nusselt number function reynolds number grashof number angle forced natural convection directions consider flow heated cylinder universal correlation accurately predicts nusselt number function parameters especially opposing convection flows natural convection forced convection revisit classical problem employing modern tools machine learning develop general multi fidelity framework constructing stochastic response surface nusselt number particular combine previously developed experimental correlations low fidelity model direct numerical simulations high fidelity model using gaussian process regression autoregressive stochastic schemes framework high fidelity model sampled times inexpensive empirical correlation sampled high rate obtain mean nusselt number directly stochastic multi fidelity response surface also propose improved correlation new correlation seems consistent physics problem correct vectorial addition forced natural convection pre factor weighs differently forced convection turn results new definition effective reynolds number hence accounting incomplete similarity mixed convection forced convection addition due probabilistic construction quantify uncertainty associated predictions information fusion framework useful elucidating physics flow especially cases anomalous transport interesting dynamics may revealed contrasting variable fidelity across models paper focus thermal mixed convection multi fidelity framework provides new paradigm could used many different contexts fluid mechanics including heat mass transport also combining various levels fidelity models turbulent flows
objective investigating strategies nurses use watch hospitalized elderly method exploratory study qualitative nature research conducted university hospital fifteen clinical nurses facilitate data collection used interview technique empirical material analyzed qualitatively using technique content analysis results qualitative analysis emerged three themes reception individualized nursing care respect autonomy elderly patients respect beliefs values privacy identity elderly patient recovery verbal nonverbal communication patient family conclusion study demonstrates commitment nurses participating research regarding humanized nursing care directed hospitalized elderly
protecting control planes networking hardware high rate packets critical issue networks operation one common approach conventional networking hardware offload expensive functions onto hard wired offload engines asics approach inadequate openflow networks restricts certain amount flexibility network control openflow tries provide therefore need control plane protection mechanism openflow switches last resort preserving flexibility network control paper propose mechanism filter packet messages include packets handled control plane openflow networks without dropping important ones network control switches record values packet header fields sending packet messages filter packets values recorded ones controllers set header fields advance whose values must recorded header fields selected based controller design implemented evaluated proposed mechanism prototype software switch concluding dramatically reduces cpu loads switches passes important packet messages network control
miniaturized thin film transparent ultrawideband uwb antenna design band notch presented pair split ring resonators srrs placed besides radiating element realize band notch centered ghz proposed transparent antenna covers whole ghz uwb frequency band notch ghz isolate interferences wireless local area network wlan dedicated short range communication dsrc applications transparency antenna enabled fabrication conductive silver coated thin film aght hence proposed transparent antenna suitable uwb home entertainment network ieee uwb network green building applications high data rates required multimedia transfer implementation proposed transparent antenna reduce space consumption due low thickness low profile time increasing aesthetic values installed wireless system due high transparency
flatness khpo kdp crystal important effect inertial confinement fusion system method improve flatness kdp crystal implementation machine tool design presented paper finite element model whole machine tool built describe tool tip displacement cutting force along cutting path influence axial radial bearing stiffness aerostatic spindle machined surface flatness discussed furthermore novel adjusting mechanism used adjust squareness spindle slide designed new machining process proposed improve flatness machined surface machining trials carried evaluate validate effectiveness presented approach simulation
context pirfinedone pfd novel agent potential prevent scarring eyes pfd eye drops exhibits poor bioavailability whereas feasibility using contact lens ocular drug delivery device initiated novel possibilities objective evaluate delivery pfd soft contact lens scl vivo screened suitable lens material pfd among various commercially available scl materials vitro material methods firstly different scls diopter respectively soaked pfd loading solution fully absorb drug placed fresh phosphate buffered saline pbs release drug pfd concentration pbs determined ultraviolet absorbance secondly immersing pfd eye drops polymacon lens diopter placed cornea new zealand rabbits pfd concentrations detected high performance liquid chromatography hplc tears aqueous humor conjunctiva cornea sclera different time points results pfd showed affinity phema based lenses polymacon lens slowly released amount pfd lens vitro compared eye drops drug loaded scls greatly enhanced retention time concentrations pfd cornea aqueous humor consequently improved bioavailability pfd conclusion polymacon based scl probably promising vehicle effective ophthalmic delivery system pfd
immunodominance clone selection algorithm icsa robust effective metaheuristic method feature selection problem however icsa usually slow finding optimal solution paper propose parallel immunodominance clone selection algorithm picsa graphics processing unit gpu improve speedup icsa feature selection problem parallel program considerably accelerate feature selection operator immunodominance operator efficiently connects local global information makes algorithm able jump local optimum easily obtain global optimum comparing parallel languages open computing language opencl advantages efficiency portability therefore use opencl implement algorithm intel many integrated core different gpu platforms experiment results obtained using high dimensional uci machine learning image texture datasets demonstrate picsa algorithm allows one achieve good acceleration ratio maintaining similar classification accuracy serial icsa program besides opencl based implementation picsa shows good portability many integrated core different gpu platforms well copyright john wiley sons ltd
menopause increased prevalence metabolic syndrome mets central obesity seems increase hot flashes hfs visfatin inflammatory adipokine secreted visceral fat investigated visfatin levels relationship hot flash number bmi postmenopausal women mets also evaluated effect genistein isoflavone effective reducing hfs visfatin levels hfs year treatment randomized double blind placebo controlled trial postmenopausal women mets randomly assigned receive placebo genistein daily year main outcome measures hot flashes number circulating visfatin levels evaluated visfatin significantly correlated bmi hfs number women mets basal months results indicate strong correlation significant effect genistein reducing hfs visfatin women mets present study suggests visfatin plays role vasomotor symptoms least postmenopausal women metabolic syndrome genistein may reduce hfs decreasing circulating levels inflammatory adipokine
new pass log domain filter presented circuit based integrator loop current sources filter circuit simple structure since uses bipolar junction transistors bjt grounded capacitor configuration offers large dynamic range low power supply higher frequency operation filter large bandwidth due inherent current mode nature log domain properties phase angle electronically tuned bias current circuit implemented integrated form pspice simulations given confirm theoretical analysis
menopause cardiovascular risk factor women cardiovascular changes perimenopause increase risk observed influence plasma adrenalin norepinephrine metabolites cardiovascular system rectification effect estrogen ovariectomized rats fifty four adult female sprague dawley rats randomly divided sham sham ovariectomized ovx ovariectomized estrogen treatment groups ovx rats sham ovx groups given normal saline ovx group given estradiol valerate beginning weeks ovariectomy continuing weeks radioimmunoassay high performance liquid chromatography high performance liquid chromatography tandem mass spectrometry chromatography spectrophotometry used detect estradiol adrenalin norepinephrine metanephrine normetanephrine plasma vanillylmandelic acid urine echocardiography doppler blood flow detection technologyand hamnatodynamometer applied assess cardiovascular function ovariectomy levels estrogen reduced adrenalin metanephrine increased norepinephrine normetanephrine plasma vanillylmandelic acid urine decreased symptoms indicative cardiac diastolic dysfunction including decreased diastolic left ventricular cavity capacity increased wall thickness decreased cardiac rate observed different degrees vasomotor dysfunction appeared different peripheral positions tail vessels relatively systolic conditions however claw pad vessels diastolic besides blood pressure also increased ovariectomy estrogen levels reduced metabolic processes adrenalin epinephrine changed impacted cardiovascular functions changes adrenalin norepinephrine metabolites correlated cardiovascular function cardiovascular disease occurred pen menopausal period estrogen replacement therapy mitigate rectify improve menopause related conditions hot flash elsevier inc rights reserved
cus brass mesh successfully developed counter electrode cds quantum dot sensitized solar cell qdssc attain power conversion efficiency pce front side light illumination equivalent cus brass sheet based qdssc furthermore cus brassmesh achieved pce upon light illumination side first time appears cus brass mesh used fabricate cost effective dual side illuminated qdsscs lightweight applications elsevier rights reserved
present report describes comparison conservative approach platelet rich plasma prp injections treatment iii grade muscle strain proximal femoral bicep junction two subjects matched age sex trauma diagnosis clinical conditions presentation subject treated prp able walk without pain week first injection able start physiotherapy programme weeks injury contrary subject conservatively treated able walk without pain months injury thus delaying beginning physiotherapy protocol seven months injury showed satisfactory recover setting early treatment muscle strain injection prp allowed early mobilization leading faster complete recovery
background etanercept highly recommended patients ankylosing spondylitis efficacy confirmed genetic polymorphisms affecting drug metabolism drug receptor lead interindividual variability drug disposition efficacy therefore study aims investigate whether abcb gene polymorphisms predict therapeutic response etanercept patients methods total patients hospital recruited study december may frequency distributions genotype allele detected polymerase chain reaction pcr electrophoresis verification enzyme products method patients received etanercept treatment weeks followed would evaluated bath disease activity index basdai score improvement assessment spondyloarthritis international society asas score improvements explore relationship genotype abcb gene polymorphisms therapeutic response etanercept patients results weeks basdai score mean improvement value genotype ratios patients genotype reaching basdai asas evaluation criteria respectively results indicated efficacy etanercept promoted genotype basdai score mean improvement value genotype weeks ratios patients genotype reaching basdai asas evaluation criteria respectively results indicated efficacy etanercept promoted genotype however significant associations observed therapeutic response etanercept patients conclusion abcb gene polymorphisms may associated efficacy etanercept patients abcb gene polymorphisms act biological indicators etanercept efficacy abbreviations ankylosing spondylitis basdai bath ankylosing spondylitis disease activity index crp reactive protein esr erythrocyte sedimentation rate pcr polymerase chain reactions snp single nucleotide polymorphism
recently online input selection gained increasing attention evolving fuzzy models paper proposed new evolving fuzzy system referred evolving heterogeneous fuzzy inference system ehfis simultaneously perform local input selection system identification evolving integrative manner introduced ehfis structured fuzzy rules different effective input variables achieved inclusion parameters local input selectors structure takagi sugeno system online learning algorithm proposed identify ehfis premise parameter learning rule evolution take place usage incremental evolving clustering partitioning data space local input selection strategy based switching neighboring model adopted fuzzy rules input structure form new category category parameters linear models consequent parts updated weighted recursive fuzzily weighted least squares estimator performance proposed ehfis evaluated compared several simulations hand made well real life datasets
hartley guinea pigs widely used animal models disease particularly studies osteoarthritis purpose study investigate lesions costal cartilage male month old hartley guinea pigs routine histological sections costal cartilage costochondral junction longitudinal cross sections sternum evaluation bone marrow examined animals histological lesions involving costal cartilage included matrix degeneration mineralization reduced cellularity evidence chondrocyte necrosis lesions contained blood vessels contained central osseous metaplasia cartilage lesions accompanied degeneration sometimes regeneration fibrosis adjacent skeletal muscle animals lesions costal cartilage interpreted dystrophic mineralization unknown cause appear incidental findings although bear resemblance lesions occurring tietze disease humans significance lesions skeletal muscle unclear histological lesions cartilage matrix degeneration mineralization sites knowledge reported previously
containing high salinity biotoxic organic compounds reverse osmosis concentrate municipal wastewater treatment plants high environmental risks aim study investigate feasibility concentrate treatment using microbial electrolysis desalination chemical production cell medcc concentrate put desalination chamber acid production cathode chambers contained nacl within operation maximum desalination rate significant cod removal concentrate achieved medcc although humic like fulvic acid like organic compoundscould transfer desalination chamber acid production chamber minimum maximum acid production cathode chambers reached respectively average total energy consumption kwh among provided bioenergy substrate utilization acid alkali recovery cod rejection treated concentrate low electricity consumption medcc indicate medcc may novel method concentrate treatment practical applications elsevier rights reserved
three theorems presented relate problem stabilizing pid controller design interval time delay plants present counterexample results elsevier ltd rights reserved
background studies indicate exposure polycyclic aromatic hydrocarbons pah associated adverse respiratory allergy outcomes exposure pah may impair immune function foetus subsequently responsible increased susceptibility children allergic diseases objectives aim present study assess association mother exposure pah pregnancy allergy diseases infants also assessed associations using measured pah exposure children urine first two years life methods current analysis restricted mothers children lodz district women interviewed three times pregnancy order collect demographic socio economic medical history data children health status assessed age months repeated two years age associations dependent dichotomous variables urine concentrations hydroxypyrene analysed using logistic regression results showed higher urine concentrations mothers weeks pregnancy increased risk frequent respiratory infections children first year life higher concentrations children urine increased risk food allergy children first two years life conclusions study suggests awareness environmental factors may affect children health since pah showed risk factor airway infections food allergy children adjustment risk factors seicap published elsevier espana rights reserved
magnetorheological fluid type smart material control mechanical properties magnetic field iron particles fluid form chain structures direction applied magnetic field known effect resulting variation stiffness shear modulus damping tribological characteristics fluid effect depends density particles fluid strength magnetic field experiments conducted evaluate friction property reciprocating motion changing types fluid strength magnetic field material aluminum brass steel chosen specimen common material mechanical applications surfaces specimen also observed optical microscope experiments compare surfaces test conditions comparing results show friction coefficient increases strength magnetic field increases regardless types fluid material also density particle fluid affects friction characteristic results research used improve performance mechanical applications using fluid
last years two new cardiovascular drug classes namely inhibitors dpp neprilysin developed cases clinical evidence potential induce angioedema known already blockers renin angiotensin aldosterone system raas majority angioedema induced dpp inhibitors occurs concomitant treatment acei therefore likely mediated overactivation bradykinin type receptors striking contrast molecular pathways causing angioedema induced neprilysin inhibitors sacubitril unclear although contribution bradykinin appears likely nevertheless clinical evidence suggesting inhibition might relieve symptoms prevent invasive treatment including coniotomy tracheotomy angioedema caused drugs therefore risk angioedema always considered especially ambulatory care situations patients rapid access intensive care
background anticoagulant therapy mainstay treatment subsequent major orthopedic surgeries evidence linking anticoagulant therapy osteoporosis delayed fracture healing conclusive previously reported rivaroxaban significantly inhibited cell growth energy metabolism human osteoblastic cell line study analyzed response primary female osteoblast cells rivaroxaban combination various bone modulating hormones methods bone samples taken premenopausal pre postmenopausal post women cells isolated sample cultured sub confluence sample treated rivaroxaban combination following hormones hormones alone hours estradiol estrogen receptor agonist ppt estrogen receptor agonist dpn parathyroid hormone pth vitamin analog jkf results effects observed exposure rivaroxaban alone pre post cells exposed bone modulating hormones control experiment dna synthesis creatine kinase specific activity significantly stimulated greater response pre cells cells exposed rivaroxaban combination bone modulating hormones increased dna synthesis specific activity previously observed completely attenuated conclusions rivaroxaban significantly inhibited stimulatory effects bone modulating hormones pre post primary human cell lines finding may clinical relevance patients high risk osteoporosis managed rivaroxaban factor inhibitors
purpose internet social media offers rich source soliciting public views health issues qualitative research using youtube platform aimed explore public perspectives management dental fear anxiety dfa pediatric patients methods using three keywords dental fear dental phobia dental anxiety youtube videos searched twenty seven videos related dfa children adolescents reviewed three investigators including nondental layperson inductive thematic analysis adopted interpreting data results several strategies considered useful controlling dfa pediatric patients including verbal nonverbal communication establish closeness effective guidance explanation permission seeking reassurance negotiation desensitization dental settings procedures tell show positive reinforcement distraction imagination thoughtful designs clinic parental presence support self coping strategies adopted patients alleviated dfa self reasoning trust building long term connection dentists clinical competence favorable treatment outcomes state art devices technologies dental lasers intraoral camera adapted anaesthesia method contributed reducing dfa conclusions authentic testimonials youtube videos endorsed interpreted variety strategies adoptable patients parents dental professionals managing children adolescents dental fears anxieties
objectives burden hiv aids borne disproportionally growing number racial ethnic minorities socioeconomically disadvantaged individuals developing mhealth interventions everyday self management needs persons living hiv plwh challenging given current constraints healthcare system especially underserved communities order develop effective evidence based mhealth self management interventions need better understanding factors associated mhealth research purpose study assess factors associated plwh participation research using smartphones methods conducted prospective cohort study parent study examine relationships among hiv self management age gender mental wellness relevant study analyzed relationship self reported use smartphones willingness use smartphone research predictor variables including hiv stigma social isolation social integration functions depression selected variables previous work indicated may influence smartphone mhealth use also tend elevated plwh results found increased age hiv stigma social isolation negatively associated smartphone use supports use smartphones conducting research plwh also suggests age stigma social integration functions social isolation need considered research involving plwh conclusions findings support smartphone use research involving plwh however future mhealth interventions targeting plwh take account inverse relationship smartphone use age hiv stigma social isolation predictor variables
popularity internet things lots resource constrained devices equipped sensors actuators pervasively deployed compose smart environment big data obtainable system analytics thus achieve human centric purposes one human centric system smart home analyze big data recognize contexts corresponding preferences service configuration thus provide context aware services however since big data generated real time huge amount analytics based conventional supervised way desirable due requirement human efforts addition usually multiple inhabitants multiple combination contexts home environment difficult fully collect possible context combination well corresponding preferences advance therefore paper proposes unsupervised nonparametric analytics method framework human centric smart homes automatically discover contexts corresponding service configurations models resulting proposed analytics also used determine preference context combination unseen
background intravenous infusion adenylate cyclase activating polypeptide pacap provokes migraine like attacks migraine sufferers whether aggregation migraine first degree relatives contributes discrepancy pacap induced response unknown hypothesized genetic enrichment plays role triggering migraine migraine without aura patients high family load first degree relatives migraine would report migraine like attacks intravenous infusion human pacap methods study allocated previously genotyped migraine without aura patients receive intravenous infusion pmol min pacap recorded migraine like attacks including headache characteristics associated symptoms information familial aggregation obtained telephone interview first degree relatives using validated semi structured questionnaire results pacap infusion induced migraine like attack nine patients high family load compared low family load explorative investigation found migraine response pacap associated risk allele mefd confers increased risk migraine without aura may regulate pacap expression conclusion migraine response pacap infusion migraine without aura patients associated high family load risk allele mefd
introduction migraine long known common complex disease caused genetic environmental factors pathophysiology specific genetic susceptibility poorly understood common variants explain small part heritability migraine thought rare genetic variants bigger effect size may involved disease since migraine tendency cluster families family approach might way find variants also indicated identification migraine associated loci classical linkage analyses migraine families single migraine study using candidate gene approach performed identifying rare mutation tresk potassium channel segregating large family migraine aura finding later become questioned technologies next generation sequencing ngs provides affordable tool investigate genetic variation entire exome genome family based study design using ngs described paper also review family studies using ngs successful finding rare variants common complex diseases order argue promising application family approach migraine method pubmed searched find studies looked rare genetic variants common complex diseases family based design using ngs excluding studies looking novo mutations using candidate gene approach studies cancer issues nature genetics plos genetics utai june screened relevant papers reference lists included relevant papers also searched description family based study design using ngs house protocol used results thirty two successful studies covered different common complex diseases included paper also found single migraine study twenty three studies found one family specific variants less five studies found several possible variants genome wide significant four studies performed follow analyses unrelated cases controls calculated odds ratios supported association detected variants risk disease studies diseases identified rare variants segregated fully large degree disease pedigrees conclusion possible find rare high risk variants common complex diseases family based approach one study using family approach ngs find rare variants migraine already published strong limitations studies way
ionic polymer metal composite actuators ipmcs new kind smart material taken much attention suitable candidates next generation actuators micro electromechanical systems medical devices micro air vehicles paper new kind ipmcs developed incorporating sulfonated poly styrene maleic anhydride ssma nation structure overcome major drawbacks traditional electro active polymers results show ion exchange capacity water uptake ratio ssma nation membrane increased dramatically compared general ipmcs maximum bending displacement maximum blocking force ssma reinforced ipmcs improved greatly ssma ipmc exhibited maximum bending displacement times ssma ipmc exhibited maximum blocking force times
reinforced soil foundations rsfs employed engineering practice increase soil bearing capacity reduce potential footing settlement aim study develop analytical solutions estimating ultimate bearing capacity strip footings rsfs general failure mode rsfs first proposed based previous studies conducted authors test results literature study limit equilibrium stability analysis rsfs performed based proposed failure mechanism new bearing capacity formulas consider confinetnent membrane effects reinforcements increase ultimate bearing capacity developed strip footings rsfs several special cases rsfs presented discussed proposed model verified experimental data reported published literature predicted ultimate bearing capacity good agteement results model tests reported literature study showed depth punching shear failure zone depends relative strength reinforced soil layer underlying unreinforced soil layer directly related reinforced ratio japanese geotechnical society production hosting elsevier rights reserved
beta galactopyranosyl beta galactopyranosyl beta galactopyranosyl beta glucopyranose included galacto oligosaccharides goss produced beta galactosidase derived bacillus circulans known induce particularly strong allergies high purity essential use standard quantify amount goss however isolation high purity never reported study achieved synthesis combination organic enzymatic chemical syntheses short time first report isolated high purity elsevier ltd rights reserved
background crohn disease chronic disabling condition curative medical treatment current treatments provide increasingly sustainable control disease allow patients better quality life limited evidence supporting management specific clinical situations thus precluding evidence based approach aims help clinicians making informed treatment decisions group french gastroenterologists experience management met develop straightforward practical algorithms based european crohn colitis organisation ecco recommendations methods experts opinion developed following nominal group consensus methodology nine clinical situations identified mildly active uncomplicated moderately active without poor prognostic factors uncomplicated severely active perianal single fistula perianal complex fistula without abscess complicated abscess intestinal stricture post operative two working groups formed proposed algorithms approved two thirds majority nominal group results algorithms represent pragmatic consensus group experts gastroenterology modalities therapeutic care different clinical situations available via web application www algorithmici com editrice gastroenterologica italiana published elsevier ltd rights reserved
single issue protests online mobilization proliferated wake social media significant ground covered regarding changing possibilities mobilization question specific circumstances condition political impact online mobilization public protests received much less attention last couple years greenlanders increasingly employed facebook mobilize populace arrange public demonstrations noteworthy results arguing single issue protests separated issues concerned paper explores single potential trivial political issue new parliament building developed prestige project supported nearly unanimous parliament public contested issue failed political project paper invokes actor network theory account trajectory issue translated along way actors built broke alliances concepts mobilizing structures opportunity structures framing processes employed shed light conditions possibilities emergence development impact protest parliament building finally paper discusses social media impact image politically engaged inuit power relations citizens parliament greenland discussion paramount importance greenlanders struggling colonial heritage constructing greenlandic democracy
due rapid developments research areas medical imaging medical image processing robotics computer assisted interventions cai becoming integral part modern patient care software engineering point view systems highly complex research benefit greatly reusing software components supported number open source toolkits medical imaging cai medical imaging interaction toolkit mitk public software library ultrasound imaging research plus slicer independent inter toolkit communication open image guided therapy link openigtlink used combine advantages toolkits enable easier realization clinical cai workflow mitk openigtlink presented network interface within mitk allows easy use asynchronous two way messaging mitk clinical devices toolkits performance interoperability tests mitk openigtlink carried considering whole cai workflow data acquisition processing visualization present mitk openigtlink applied different usage scenarios performance tests tracking data transmitted frame rate latency transmission images typical ultrasound greyscale high definition resolutions possible respectively integration openigtlink mitk protocol supported established open source toolkits field eases interoperability mitk toolkits plus slicer facilitates cross toolkit research collaborations mitk submodule mitk openigtlink provided open source bsd style licence http mitk org
security protocols key ensure network security context state art many methods developed analyze security properties security protocols ban logic theorem proving model checking etc paper used model checking method formally verify security protocols high degree automation briefness effectiveness model checker spin sound algorithm design extraordinary ability checking good support ltl paper studied use spin security protocols proposed effective intruder model formally verify security properties security protocols authentication method paper decreased number model states wide margin avoided state space explosion effectively paper exampled nspk protocol protocol good experimental results shown
static slicing popular program analysis used software engineering find parts program affect parts unfortunately static slicing often produces large imprecise results conservative nature dynamic slicing alternative cases requires detailed runtime information hard impossible obtain create often case users report bugs deployed software paper significantly improve precision static slicing prioslice novel technique exploits insight statements static slice equally likely affect another statement failing point prioslice first computes probabilistic model dependencies program model data dependencies likely occur others control dependencies less likely data dependencies propagate effects errors prioslice traverses program backwards like static slicing order defined computed dependence probabilities study fault localization various java subjects indicates prioslice help localize faults much effectively existing static slicing approaches elsevier inc rights reserved
rural electrification rates india lag behind government goals part due inability distribution companies discoms fund central grid expansion absence central grid electrification mini grids offer significant potential immediate pathway toward rural electrification attendant gains economic growth productivity yet private investment mini grids virtually absent india using comprehensive life cycle cost analysis find mini grids based solar power storage economical incumbent energy services available households without central grid connection current law prospective entrepreneur india require license certification order build mini grid subsequently provide electricity services area covered said installation conversely legal regulatory framework specifies happen central grid extended area already covered mini grid report detailed survey evidence interviews entrepreneurs analysts policymakers whose assessments converge point mini grid investments would jeopardized event central grid extension precisely discoms would regulatory order provide electricity services highly subsidized rates well full economic cost fieldwork suggests threat central grid extension gateway barrier preventing mini grid development india issues associated gateway barrier common elements called holdup problem identified economics organizations two recent federal policy guidelines one actual state level policy addressing regulatory status mini grids examine effectiveness policies proposals terms entrepreneur willingness develop mini grids future elsevier ltd rights reserved
wide spread use biometric based authentication implies need secure biometric reference data various template protection schemes introduced prevent biometric forgery identity thefts cancelable biometrics visual cryptography two recent technologies introduced address concerns regarding privacy biometric data improve public confidence acceptance biometric systems cancelable biometrics important technique allows generation revocable biometric templates number biometric instances limited compromised lost forever cancelable biometrics allows templates cancelled revoked like passwords innumerable times recently various approaches utilize visual cryptography secure stored template impart privacy central databases introduced work attempts summarize existing approaches literature making use two technologies protect biometric templates
daily life emotional events often discussed others influence social interactions veracity emotional memories rarely investigated authors choi kensinger rajaram memory cognition previously demonstrated categorical relatedness information controlled emotional items accurately remembered neutral items present study examined whether emotion would continue improve accuracy memory individuals discussed emotional neutral events others two different paradigms involving social influences used investigate question compare evidence paradigms participants studied stimuli grouped conceptual categories positive celebration negative funeral neutral astronomy valence hour delay recognition memory tested studied items categorically related lures first paradigm recognition accuracy compared memory tested individually collaborative triad second paradigm recognition accuracy compared prior retrieval session occurred individually confederate supplied categorically related lures paradigms emotional stimuli remembered accurately neutral stimuli pattern preserved social interaction occurred fact first paradigm trend collaboration increase beneficial effect emotion memory accuracy second paradigm emotional lures significantly less susceptible social contagion effect together results demonstrate emotional memories accurate nonemotional ones even events discussed others experiment even discussion introduces misinformation experiment
saving power becomes one main objectives information technology industry research companies consume lot money shape power consuming virtual desktop infrastructure vdi new shape delivering operating systems remotely operating systems executing cloud data center users desktops applications accessed using thin client devices thin client device consisting screen attached small cpu vdi benefits terms cost reduction energy saving paper increase power saved grinfy system without vdi grinfy save least energy consumption users companies integrating vdi computing systems using grinfy power efficiency saving improved save improving increasing energy saving features vdi also illustrated experiment integrated grinfy system increase percentage energy saved
hybrid electric vehicles offer potential fuel consumption improvements compared conventional vehicle powertrains fuel consumption benefits realised utilising hybrid electric vehicle architecture dependent much braking energy regenerated well regenerated energy utilised number power management strategies proposed literature owing prospect real time implementation many proposals centred use heuristics despite research advances made key challenge heuristic strategies remains achieving reasonable fuel savings without depleting battery state charge end trip view challenge paper offers two main contributions existing energy management literature first novel simple effective heuristic control strategy employs tuneable parameter percentage maximum motor tractive power decide control sequence impressive fuel savings achieved without depleting final state charge battery battery energy second quantitative exploration braking patterns impact kinetic energy regeneration potential proposed heuristic control strategy explored range driving cycles reflect different driving scenarios results analysis show fuel savings much achieved japan driving cycle comparison suboptimal controller whose control signals derived dynamic programming optimal control proposed strategy found outperforming achieved impressive real time fuel savings without much penalty final state charge battery gentle braking patterns also found significantly improve brake energy regeneration electric motor
review heap leach projects countries provides starting point series experiments degrees vertical pressure kpa examine short term puncturing development geomembrane strains could affect longer term performance underliners gravel sand gravel sand caused significant puncturing excessive strains geomembrane conditions examined shape underliner grading curve much greater effect potential puncturing magnitude strains geomembrane maximum particle size six granular underliners examined best performance well graded gravelly sand silt offered sufficient support minimize strains geomembrane due overliner inducing significant strains directly underliner nevertheless even case maximum strain almost double maximum recommended literature ensuring good long term performance geomembrane consideration composite liners gcls compacted clay liners shows deformable foundation larger indentations strains induced geomembrane given overliner specific conditions examined shown apparent improvement performance lldpe geomembrane versus hdpe geomembrane tested geotextile protection layer geomembrane also found insufficient prevent significant strains geomembrane due overliner examined elsevier ltd rights reserved
socioeconomic status ses consistently linked poorer access utilization outcomes health care services relationship understudied adolescent substance abuse treatment research study examined ses differences adolescent treatment participation long term outcomes abstinence step attendance five years treatment data adolescents ages recruited intake substance abuse treatment four kaiser permanente northern california outpatient treatment programs follow interviews adolescents parents conducted years response rates across time points using parent ses proxy adolescent ses socioeconomic differences found treatment initiation treatment retention long term abstinence alcohol drugs parent education parent income significantly associated step attendance post treatment adolescents higher parent edification likely attend lower parent education findings suggest lack socioeconomic disparities substance abuse treatment participation adolescence potential disparities post treatment step attendance transition adolescence young adulthood elsevier ltd rights reserved
background alcohol abuse important public health problem frequently unrecognized among people living hiv aids plwha requires investigation intervention usually associated lower adherence highly active antiretroviral therapy haart also produce adverse clinical outcomes changes certain hiv markers particularly cell counts hiv viral loads vls thus study aimed evaluate prevalence alcohol abuse among plwha associated risk factors effects cell counts hiv vls southern brazil methods december july patients interviewed reference hospital southern brazil instrument used alcohol use disorder identification test audit cutoff eight points applied socioeconomic demographic clinical laboratory data also collected statistical analysis included poisson regression evaluate factors associated alcohol use disorder linear regression performed assess relationship audit scores cell counts hiv vls results alcohol abuse present respondents possible dependence present risk factors identified included male mixed black skin color low education use intravenous inhaled drugs higher audit score associated lower cell count associated higher hiv values conclusions results show importance screening alcohol abuse group prevalence alcohol abuse high associated socioeconomic factors use illicit drugs moreover audit score negatively affected cell counts well
purpose authors aimed analyze causes outcomes golf related ocular injuries retrospective meta analysis literature review original case series methods forty one articles identified pubmed search resulted included studies yielding subjects included articles described ocular golf injuries presented institution determined period eight factors analyzed age sex location mechanism injury protective eyewear use resulting open globe injury resulting enucleation visual acuity changes results subjects wore adequate protective eyewear significantly subjects injured golf balls golf clubs foreign body ratio golf ball club injuries significantly higher adults children forty seven injuries resulted open globe whereas injuries resulted enucleation mean logmar visual acuity improved treatment lines improvement conclusion reported ocular golf injuries occur less frequently ocular sports injuries may result devastating outcomes supervision children using golf equipment encouraged
although often ignored fmri studies moment moment variability blood oxygenation level dependent bold signals reveals important information brain function indeed higher brain signal variability associated better cognitive performance young adults compared children elderly adults functional connectivity common approach resting state fmri analysis scaled variance thus alterations might confounded driven bold signal variance alterations chromosome deletion syndrome neurodevelopmental disorder associated vast cognitive clinical phenotype date several resting state fmri studies reported altered functional connectivity however bold signal variance yet analyzed employed pls correlation analysis reveal multivariate patterns diagnosis related alterations age relationship throughout cortex patients years old healthy controls age range address functional connectivity default mode network influenced bold signal fluctuations conducted analysis seed voxel connectivity posterior cingulate cortex pcc compared resulting brain patterns bold signal variance lower mainly regions default mode network dorsolateral prefrontal cortex higher large parts temporal lobes regions bold signal variance correlated age healthy controls patients suggesting deviant developmental trajectories child adulthood positive connectivity pcc within default mode network well negative connectivity towards frontoparietal network weaker patients furthermore showed lower functional connectivity pcc driven higher bold signal variability results confirm strong implication bold variance aging give initial insight relationship functional connectivity dmn
due extensive use network services emerging security threats enterprise networks deploy varieties security devices controlling resource access based organizational security requirements requirements need fine grained access control rules based heterogeneous isolation patterns like access denial trusted communication payload inspection organizations also seeking usable optimal security configurations harden network security within enterprise budget constraints order design security architecture distribution security devices along security policies satisfies organizational security requirements well business constraints required analyze various alternative security architectures considering placements network security devices network corresponding access controls paper present automated formal framework synthesizing network security configurations main design alternatives include different kinds isolation patterns network traffic flows framework takes security requirements business constraints along network topology inputs synthesizes cost effective security configurations satisfying constraints provides placements different security devices optimally distributed network according given network topology addition provide hypothesis testing based security architecture refinement mechanism explores various security design alternatives using configsynth improves security architecture systematically increasing security requirements demonstrate execution configsynth refinement mechanism using case studies finally evaluate scalability using simulated experiments
present iterative algorithm called symmetric tensor eigen rank one iterative decomposition steroid decomposing symmetric tensor real linear combination symmetric rank unit norm outer factors using eigendecompositions least squares fitting originally designed symmetric tensor order power two steroid shown applicable order innovative tensor embedding technique numerical examples demonstrate high efficiency accuracy proposed scheme even large scale problems furthermore show steroid readily solves problem nonlinear block structured system identification nonlinear state space identification elsevier rights reserved
backgroundcertain individuals appear predisposed recurrent pasture associated laminitis previous studies predominantly investigated risk factors disease occurrence objectivesto investigate risk factors pasture associated laminitis prior disease occurrence study designprospective cohort study methodsnon laminitic ponies aged years recruited body condition score bcs height weight crest height thickness measured overnight dexamethasone suppression test performed plasma serum adiponectin leptin triglyceride basal insulin insulin post dexamethasone insulin like growth factor igf igf binding protein igfbp igfbp reactive protein von willebrand factor soluble selectin selectin concentrations assayed follow data obtained owners annually years ascertain occurrences veterinarian diagnosed pasture associated laminitis data analysed multivariate logistic regression receiver operating characteristic roc curves analysis performed significant risk factors cut values determined resultsa total animals median interquartile range age years recruited mares geldings common breeds welsh shetland cob overall animals overweight obese bcs ideal weight bcs underweight bcs years respectively animals reported laminitis plasma adiponectin serum basal insulin insulin post dexamethasone levels significantly associated laminitis occurrence cumulatively years use area roc curves distinguish animals develop laminitis showed good basal insulin year fair others poor insulin post dexamethasone levels accuracy main limitationsanimals evaluated single time point biomarkers assayed using single assays conclusionsrisk factors future laminitis prior disease occurrence include low plasma adiponectin high serum basal insulin insulin post dexamethasone concentrations
paper shows design methodology humanoid robotic arm realistic mechanical structure performance realistic mechanically robust structure prosthetic arm developed solid works torque power requirements cost estimation assessed systematically interfacing model simmechanics software robotic arm equipped several robot servo motors perform links arms perform arm movements interfacing robot servo controller picf microcontroller robot servo controller capability drive servo controlled position speed acceleration modes due complexity arm kinematics machine learning techniques rely less precise mathematical analysis implemented anfis one machine learning technique helps decision making control robotic arms paper implements matlab derived multilayered anfis controller using picf microcontroller supervisory control dof robotic arm type robotic arm many advantages simple structure high flexibility low energy consumption quiet operation sensory feedback make prosthetic arm high resemblance normal arm good tradeoff cost performance achieved order meet goal less expensive useful robotic arm disabled practically built arm tested predefined paths random positional targets work space results shown act satisfactorily
introduction western countries obesity currently major public health issue part complex system studied alone yet often seen result qualitatively quantitatively deviant dietary intake seldom questioned symptom psychoanalytic sense part package makes sense objectives study purpose article highlight importance shame psyche obese subjects subjective backup author questions experience shame obese subjects cornerstone symptom psychoanalytic sense methods reporting clinical case author notes occurrences shame discourse patient subsequent analysis presented based transferential counter transferential relationship carry study author drew device supporting catharsis results author addresses successively complaint obese subjects effect shame shame alpha omega bulimic crises lastly body work art building monstrosity author concludes social dimension shame part symptom body transformation obese subjects discussion appears pathological shame reveals difficulty maintain sense existence reason seems important consider effect establish framework emergence latter consultations patients eating disorders conditions patient able pedestal shame voice shame support subjectivity encephale paris
multi source driving transmission systems gear assembly driven multiple induction motors extensively used new energy aerospace marine engineering fields multi source driving system faces even load distribution problem torque speed synchronization issues study synchronization characteristics multi source driving transmission system impact load different load change rates studied accurate electromechanical coupling dynamic model system considering flexible shafts support bearing meshing gear pair established applying virtual equivalent shaft elements considering time varying meshing coupling effects dynamic electric motor speed torque stator current synchronization characteristics investigated using model computational results show influence load change rate speed synchronization characteristics system minor significant influence torque stator current synchronization characteristics stator current root mean square value rms chosen feedback signal monitor synchronization characteristics system proposed research provides theoretical basis formulation synchronization control strategy multi source driving transmission systems
objectives assess accuracy magnetic resonance enterography mre determining site extent complications crohn disease correlation capsule endoscopic colonoscopy findings patients methods performed observational prospective study patients suspected crohn disease already diagnosed patients crohn disease bowel inflammatory changes analyzed involved bowel segment associated lymph nodes abscesses fistulas also evaluated results mre diagnostic small bowel inflammatory changes sensitivity specificity values respectively compared capsule endoscopy overall accuracy compared capsule endoscopy large bowel inflammatory changes mre showed sensitivity specificity values respectively compared colonoscopy overall accuracy compared colonoscopy severely inflamed segments correctly identified false positive findings study conclusion mre practicable non invasive provides additional information regarding areas accessible endoscopy egyptian society radiology nuclear medicine production hosting elsevier open access article license
violent media consumption often thought lead aggression violence especially juveniles social cognitive theories assume pivotal role cognitive functions normative beliefs explanation human behaviour including violence see violent media possible potent learning environment although many studies analysed relationship violent media consumption violence longitudinal apparently study analysed mediator effects violence approving normative beliefs data western country two points time researchers assume violent media consumption aggravate already existing disposition violence due experiences parental maltreatment double dose intensifier effect methodologically described moderator effect assumptions mediation moderation tested structural equation models using cross sectional longitudinal data german panel study results show interaction effects parental behaviour violent media consumption surprisingly weak whereas influence approval violence remarkable extent mediated eventually smaller extent violent behaviour
paper presents hybrid adaptive neuro fuzzy control technique speed control bldc motor drives proposed controller integration adaptive neuro fuzzy fuzzy pid controllers objective utilize best attribute fuzzy pid controllers exhibits better response neuro fuzzy controllers error back propagation learning algorithm ebpa used train data minimize learning error validate performance proposed controller simulations done matlab comparison made fuzzy pid controllers addition performance proposed controller benchmarked controllers reported literature results proposed controller promising terms quick settling time zero peak overshoot zero steady state error
objectives exposure child abuse associated increased risk developing asthma allergies unknown risk present across generations study investigated year old children born mothers history increased risk receiving diagnosis asthma allergies methods data participants collected part babies aob study prospective pregnancy cohort pregnancy woman provided information history months postpartum provided information child medical diagnoses symptoms maternal depression anxiety assessed pregnancy months postpartum results unadjusted models showed compared children born mothers without history year old children born mothers history likely diagnosis asthma allergy maternal symptoms depression assessed late pregnancy symptoms depression anxiety months postpartum significant mediators relationship maternal year old asthma diagnosis maternal symptoms depression anxiety assessed late pregnancy also significant mediators relationship maternal year old allergy diagnosis conclusions results indicate maternal exposure associated increased risk asthma allergy year old children symptoms maternal depression anxiety identified pathways linking variables
nonverbal behavior plays important role human human interaction teaching inherently social activity exception far effect nonverbal behavioral cues accompanying lecture delivery investigated case traditional cathedra lectures students teachers located however becoming increasingly frequent watch lectures online new type setting still unclear effect nonverbal communication article tries address problem proposes experiments performed lectures popular web repository videolectures results show automatically extracted nonverbal behavioral cues prosody voice quality gesturing activity predict ratings videolectures users assign presentations
complexity pursuit recently proposed elegant simple solution blindly without measuring inputs separate modal contributions vibration responses structure potentially finds considerable interest operational modal analysis related applications paper analyses theoretical ins outs method also revises physical interpretation modal analysis context found separate components least dispersive invariant linear filtering property well characterizes modal responses lightly damped systems however also found suffer limitations blind source separation methods used state ofthe art namely difficulty separate strongly coupled modes identify complex mode shapes finally generalization proposed intends widen applicability interestingly generalized crep happens include well known sobi algorithm particular case
whereas past research focused downsides task switching present research uncovers potential upside increased creativity two experiments show task switching enhance two principal forms creativity divergent thinking study convergent thinking study part temporarily setting task aside reduces cognitive fixation participants continually alternated back forth two creativity tasks outperformed participants switched tasks discretion participants attempted one task first half allotted time switching task second half importantly studies reveal people overwhelmingly fail adopt continual switch approach incentivized choose task switching strategy would maximize creative performance findings provide insights individuals switch creativity navigating multiple creative tasks elsevier inc rights reserved
purpose adolescents anorexia nervosa face increased lifetime risk bone fragility randomized controlled study examined efficacy safety high impact activity program markers bone turnover stabilization vital signs vss methods forty one hospitalized adolescents randomly assigned routine care routine care plus jumps twice daily bone markers measured baseline days days days primary outcome change bone specific alkaline phosphatase bsap adjusted bsap median body mass index secondary outcomes serum telopeptide ntx osteocalcin safety determined comparing weight gain time vss length stay group results bsap ntx osteocalcin differ groups baseline bsap ntx associated group enrollment median body mass index vss significantly reduced intervention group compared control group days days significant difference weight gain length stay groups conclusions twice daily jumping activity failed influence markers bone turnover adolescents well tolerated shortened time vital sign stabilization slow weight gain society adolescent health medicine rights reserved
contact activation system cas kallikrein kinin system kks older recognized biochemical pathways include several proteins skirt fringes blood coagulation fibrinolytic complement renin angiotensin fields proteins initially proposed part hemostatic pathways deficiencies associated prolonged clinical assays however absence bleeding states deficiencies factor xii fxii prekallikrein high molecular weight kininogen indicates cas kks contribute hemostasis since discovery hageman factor years ago much learned biochemistry cell biology animal physiology proteins cas pathophysiologic surface defense mechanism foreign proteins organisms artificial materials kks inflammatory response mechanism targeting activation fxiia plasma kallikrein inhibition blood interacts artificial surfaces modern interventional medicine acute attacks hereditary angioedema restores vascular homeostasis fxii fxiia products arise deficiency also offer novel ways reduce arterial venous thrombosis without effect hemostasis summary revived interest cas kks due better understanding activities new appreciation systems lead several new therapies variety medical disorders
studied relation polymorphism glycoprotein breast cancer resistance protein bcrp encoded abcb abcg genes respectively pharmacokinetic variability clinical response treatment sorafenib hepatocellular carcinoma paul brousse hospital villejuif france consecutive patients advanced hcc treated single agent sorafenib enrolled sorafenib exposure measured plasma concentration oral administration bid liquid chromatography enrolled patients genotyped abcb abcg blood genomic dna extraction mass array genotyping clinical response evaluated months treatment according recist criteria significant associations sorafenib exposure studied polymorphisms observed abcb abcg abcg abcg abcb snp heterozygous patients abcb abcg abcg polymorphisms significantly associated lowest sorafenib plasma levels patients presented tendency best clinical evolution heterozygous forms studied polymorphisms could associated better therapeutic response
paper explores relationship health related quality life hrqol measures employment status light constructed index related seasonal affective disorder depends latitude day year models including demographic covariates indicators state year quarter hours darkness associated poorer hrqol turn associated lower likelihood employment relationships darkness index hrqol measures stronger overall women men inclusion darkness index hrqol measures models employment status determinants provides evidence former operates latter predicting lower likelihood employment specifying darkness index instrument hrqol additional day poor mental health per month leads percentage point increase probability unemployment among women elsevier rights reserved
finding pharmaceutically relevant target conformations arbitrary set protein conformations remains challenge structure based virtual screening sbvs growth number available conformations either experimentally determined computationally derived obscures situation inflated conformation space potentially contains viable druggable targets increase conformational complexity consequence poses selection problem address challenge took advantage machine learning methods namely sampling binary classification procedure present novel method select druggable receptor conformations specifically trained binary classifier set nuclear receptor conformations wherein conformation labeled enrichment measure corresponding sbvs classifier enabled formulate suggestions identify enriching sbvs targets six seven nuclear receptors classifier extended proteins interest simply feeding new training data sets classifier work thus provides methodology identify pharmaceutically interesting receptor conformations nuclear receptors drug targets
utility anticoagulants ischemic stroke prophylaxis elderly patients chronic kidney disease ckd atrial fibrillation remains uncertain population based retrospective cohort study determined association anticoagulant use ischemic stroke hemorrhage elderly patients years older advanced chronic kidney disease egfr min atrial fibrillation followed patients ckd new onset atrial fibrillation filled prescription anticoagulant used propensity score matched cox proportional hazards competing risk models determine time first event ischemic stroke hemorrhage mortality matching examine exposure anticoagulants matched pairs identified crude rate ischemic stroke hemorrhage anticoagulants without anticoagulants per person years respectively hazard ratios ischemic stroke hemorrhage mortality receipt anticoagulation prescription confidence interval compared non receipt anticoagulation accounting competing risk death hazard ratios ischemic stroke hemorrhage respectively findings consistent sensitivity analysis accounting time varying anticoagulant exposure thus older patients ckd atrial fibrillation receipt anticoagulant associated lower risk ischemic stroke higher risk hemorrhage lower risk mortality
hydropower long recognized renewable power source due economic reasons high medium head potentials primarily developed later low head potentials became feasible solution application modern bulb generators although bulb generators developed applied since new techniques materials used overcome technical design challenges described herein
investigate whether long term chronic treatment phosphodiesterase inhibitor vardenafil affects adrenal testicular steroidogenesis diabetic men using liquid chromatography tandem mass spectrometry longitudinal prospective investigator started randomized placebo controlled double blind clinical trial carried enrolling male patients affected type diabetes mellitus diagnosed within last years total patients followed year assigned study placebo group respectively progesterone hydroxyprogesterone androstenedione testosterone dehydroepiandrosterone dehydroepiandrosterone sulfate corticosterone deoxycortisol cortisol evaluated using liquid chromatography tandem mass spectrometry differences seen sex testicular steroids study control group adrenal gland steroids considered according zona produced significant differences seen steroid produced zona fasciculata zona reticularis dehydroepiandrosterone significantly decreased treatment study group higher levels visit visits dehydroepiandrosterone sulfate dehydroepiandrosterone ratio significantly increased treatment verum group considering adrenal zona glomerulosa corticosterone significantly changed among visits groups higher levels visit coincidence complete clinical instrumental examination performed visits according study protocol chronically administered vardenafil reduces dehydroepiandrosterone levels increases dehydroepiandrosterone sulfate dehydroepiandrosterone ratio possible consequences modulation steroidogenic enzymes tissue changes cyclic adenosine monophosphate cyclic guanosine monophosphate availability possibly stress related increase corticosterone suggested first time
overt sexual prejudice declining heterosexuals report little prejudice may still harbor subtle biases gay men lesbians examined implicit prejudice sample heterosexual college students reported little sexual prejudice using affect misattribution procedure amp psychophysiological measures affect skin conductance heart rate facial electromyographic responses recorded participants viewed photos mixed sex couples kissing rated valence arousal disgustingness sexual prejudice evident implicit amp ratings explicit ratings valence disgustingness psychophysiological responses results suggest implicit prejudice harbored young adults endorse low levels sexual prejudice cognitively emotionally based unlike fear based reactions commonly described racism limitations future directions research discussed
structural health monitoring large multispan flexible bridges particularly important important role civil infrastructure transportation systems study response yokohama bay bridge ybb three span cable stayed bridge great east japan earthquake used perform multi input multi output system identification studies extensive multicomponent measurements also used develop validate data driven nonlinear mathematical models predict response ybb various earthquake records accurately estimate damping characteristics system driven nonlinear response range combination least square parametric neural network nonparametric approaches used develop mathematical models along time marching techniques dynamic response calculations shown nonlinear mathematical models perform better equivalent linear models response prediction damping estimation importance accurate approach quantifying damping due variety nonlinear features ybb response shown study demonstrates significance constructing robust mathematical models capture correct physics underlying system used computational purposes augment experimental studies given lack suitable data sets full scale structures extreme loads availability long duration measurements great east japan earthquake many strong aftershocks provides excellent opportunity perform analyses presented study copyright john wiley sons ltd
objective paper design controller able control output angle upper limb robotic arm precision motion high speed response aim optimize best controller upper limb robotic arm system precision motion improper motion results injuries fatality loss production manufacturing system research robotic arm prototype degree freedom dof designed fabricated geared motor implemented studies carried based previous research investigate suitable type controller pid controller fuzzy logic controller chosen compared terms performances steady state error settling time rise time overshoot equipment used micro box cytron geared motor motor driver circuit micro box module acts interface hardware component matlab open loop simulations carried obtain transfer function motor substituted system simulation analysis simulation uncompensated system carried observe close loop system characteristic without controller close loop point point ptp trajectory control simulations experiments carried compensated systems using pid controller based ziegler nichols frequency response method analyses made based results obtained best type controller chosen achieving precise motion control upper limb robotic arm paper pid controller shows better performances compared fuzzy logic controller flc steady state error less settling time input reference respectively
background objective scientific literature lack variable selection classification methods considering replicated data problem motivating work consists discrimination people suffering parkinson disease healthy subjects based acoustic features automatically extracted replicated voice recordings methods two stage variable selection classification approach developed properly match replication based experimental design way statistical approach specified allows computational problems solved using easy implement gibbs sampling algorithm results proposed approach produces acceptable predictive capacity discrimination considered database despite fact sample size relatively small specifically accuracy rate sensitivity specificity respectively however important fact improvement interpretability results time shown better chain mixing lower computation time respect classification approaches presented scientific literature conclusions best authors knowledge first approach developed properly consider intra subject variability variable selection classification although proposed approach applied discrimination applied contexts similar replication based experimental designs elsevier rights reserved
paper examines whether indigenous peoples right reproductive autonomy established right self determination health international human rights law extent reproductive health rights effectively protected government sponsored population policies historically instances government population policies targeting specifically primarily indigenous peoples includes sterilisation programmes australia removal aboriginal children live foster white families well recent years peru family planning programme past decade seen important developments field particular australian government symbolically important apology stolen generation proposal state stolen generations compensation bill adopted could provide measure reparation past policies global level number important initiatives population policies developed recent second international conference population development cairo paper argues right self determination health prior informed consent includes right self government autonomy must also include indigenous right reject government policies subject communities birth control programmes
background various online applications service led development online health communities ohcs addition peer peer communication offer patients users also interaction health professionals benefits challenges patients users participation ohcs extensively studied thorough examination health professionals moderators provide clinical expertise patients users ohcs experience participation ohcs lacking objective aim study explore main benefits challenges health professional moderators participation ohcs methods study undertakes exploratory qualitative study depth semi structured interviews health professional moderators participating largest ohc slovenia med net data analysed using inductive thematic analysis approach principles grounded theory results four themes health professional moderators experiences identified benefits addressing ohc users health related needs challenges addressing ohc users health related needs health professional moderators benefits health professional moderators challenges conclusions small study demonstrates health professional participating ohcs moderators perceive facilitators patients ohc users empowering processes outcomes ohc users improve health literacy develop skills expand social support gain important resources necessary dealing health related issues health professional moderator role however also involves several duties responsibilities limitations often experienced difficulties providing patients users adequate counselling online medical service ohcs also represent important terrain personal professional empowerment health professional moderators although presence disempowering processes also needs noted elsevier ireland ltd rights reserved
study strategies serum biomarker assessment developed therapeutic monitoring hcv patients purpose serum chemokine cytokine levels measured cytometric beadarray hcv patients categorized according immunotherapy response non responder relapser rel sustained virologic responder svr results demonstrated overall increase serum chemokine cytokine levels hcv patients general therapeutic failure associated presence predominant baseline proinfiammatory pattern enhanced ccl rantes ifn alpha ifn gamma along decreased levels increased tnf rel svr displayed lower baseline proinfiammatory status decreased cxcl levels inability uphold ifn alpha levels immunotherapy characteristic serum chemokine cytokine signatures support deleterious effect proinflammatory baseline status critical role increased persistent ifn alpha levels guarantee sustained virologic response prominent baseline proinflammatory milieu observed rel yielded restricted biomarker network small number neighborhood connections whereas svr displayed network integrated cytokine connectivity noteworthy svr presented shift towards proinflammatory pattern upon immunotherapy assuming pattern similar observed rel baseline moreover immunotherapy guided rel towards profile similar svr baseline analysis baseline fold changes treatment pointed ifn alpha tnf high performance biomarkers monitor immunotherapy outcome knowledge may contribute novel insights treatment control continuous public health threat posed hcv infection worldwide elsevier rights reserved
background study aims evaluate pre postoperative health promoting lifestyle behaviors among patients undergoing coronary artery bypass graft surgery methods total patients males females mean age years range years without communication problems underwent elective coronary artery bypass graft surgery kartal kosuyolu yuksek htisas training research hospital included health promoting lifestyle behaviors assessed preoperatively six weeks following surgery using health promotion lifestyle behaviors scale results mean scores health promoting lifestyle behaviors patients six weeks following surgery significantly increased preoperative scores also significant increase scores self actualization interpersonal support sub dimensions scale scores health responsibility exercise stress management sub dimensions significantly decreased six weeks following surgery conclusion coronary artery bypass graft surgery affects health promoting lifestyle behaviors patients concluded self actualization skills patients communication immediate family increase responsibility toward health exercise levels meal arrangements stress management decrease six weeks following surgery
particle image velocimetry planar laser induced fluorescence techniques used measure flow scalloped lobed splitter mixers special attention given understanding details flow scalloped mixers role notches enhancing mixing process comparisons three mixers explained providing detailed measurements several axial cross streamwise planes scalloped lobed mixers enhance mixing two streams generating additional pair small scale streamwise vortices observed lobed mixer shear layer test condition impingement inner flow mixing duct occurs downstream lobed mixer scalloped mixer decay cross streamwise velocity starts exit plane lobed mixer initial magnitude rise streamwise decay
japanese lunar explorer selene selenological engineering explorer launched first time utilize vlbi observations lunar gravimetry investigations particularly improve accuracy low degree gravitational harmonics gravity field near limb measured combined doppler measurements enable three dimensional information extracted differential vlbi radio sources called vrad experiment involves two board sub satellites rstar vstar observed using differential vlbi measure trajectories satellites japanese network named vera vlbi exploration radio astrometry international vlbi network use multi frequency vlbi method measure angular distance two sub satellite radio sources rstar vstar observations three frequencies band mhz one band mhz method uses low power consumption carrier waves suitable positioning spacecraft japanese domestic vlbi network vera conduct vlbi observations whole mission period one year addition conduct two periods intensive observations one month duration also include international stations shanghai urumqi china hobart australia wettzell germany observations measure phase delay accuracy better rad deg band baseline length equivalent positioning accuracy moon combining data tracking selene satellites main orbiter rstar vstar different attitudes four way doppler measurements making long term observations sub satellites excess one year without maneuvering able improve accuracy lunar gravitational field known order magnitude completed development board instruments carrying pre flight tests variety conditions also undertaken test vlbi observations orbiters geotail nozomi smart international network cospar published elsevier ltd rights reserved
histoplasmosis systemic fungal infection caused dimorphic fungus histoplasma capsulatum immunocompetent individuals usually self limiting localized disease whereas immunocompromised individuals develop disseminated disease occurrence progressive disseminated histoplasmosis juvenile systemic lupus erythematosus extremely rare one reported case literature showing association therefore report case severe opportunistic fungal infection caused histoplasma year old girl diagnosed juvenile lupus erythematosus subsequently developed septic shock died disease despite aggressive antifungal therapy
aim study investigate overall root shoot allocation metal contaminants amount metal removal absorption adsorption within external root surfaces dose response water hyacinth metal uptake phytotoxicity examined single metal tub trial using arsenic gold copper iron mercury manganese uranium zinc iron also used low medium high concentration treatments test dose effect water hyacinth metal uptake water hyacinth generally tolerant metallotoxicity except total amount metals removed accumulated roots adsorbed onto root surfaces furthermore total metal assimilation water hyacinth located roots bioconcentration factor bcf exceeded recommended index used selection phytoremediating plants nevertheless bcf increased increase concentration water suggests use bcf index alone without consideration plant biomass metal concentration water inadequate determine potential plants phytoremediation accurately thus study confirms water hyacinth holds potential broad spectrum phytoremediation roles however knowing whether metals adsorbed assimilated within plant tissues well knowing allocation roots shoots inform decisions treat biomass metal recovery mode biomass reduction safe disposal phytoremediation
challenges pedagogical interaction drama related teacher student interaction aim research develop theatre based training programmes designed take advantage teachers holistic especially nonverbal communication interaction skills presence use bodies space educational settings research questions theatre based tools used teach body awareness possible use practiced body messages consciously teaching studying learning situations aim paper present background aspects theory based practical training program developed teach holistic interaction professional teachers teacher students helsinki university teacher education challenge empty space research project also present preliminary results effectiveness training programme preliminary data collection carried two groups teacher students one group qualified teachers took basic studies drama education course ects credits holistic interaction skills especially studied theatre education course ects credits course participants reflected learning answering questionnaire respondents felt learnt something new teacher student interaction importance interactions teaching mentioned paying close attention supplementary communication qualified teachers described concrete situations used new holistic interaction skills consciously results preliminary study reinforced view give indications teachers body awareness teaching situations developed methods results help develop theatre based training programme published future academy www futureacademy org
construction industry provides extensive impacts environment population increases driving pressures attempt mitigate impacts industry whole promoted developed numerous green building rating systems gbrs gbrs assign scores buildings based variety assessment criteria determine structures environmental impact previous research identified shortfalls certain areas related gbrs order gain insight systems industry survey conducted establish alternate perspective outcomes survey consistent previous research identifying requirement increase embodied energy consideration structures gbrs average estimation contribution structures life cycle consumption survey findings also identified number key areas changes consideration sustainable development could improved use findings comparison previous research outcomes would assist development supplementary mechanisms improve assessment environmental performance structures elsevier ltd rights reserved
relational databases queries simple structured language sql facilitates kind processing sql useful realize queries qualitative words used expressions high low little among others exact sql quantitative language process way work proposes use fuzzy logic respond subjective queries dataset homicides woman data brazil years used qualitative queries dataset answered using fuzzy methodology
foldable displays represent one attractive next generation display applications therefore critical analyze effects mechanical stress amorphous ingazno igzo thin film transistors tfts order apply foldable displays foldable display applications dynamic mechanical stress tests designed carried using bending radius less paper dynamic mechanical bending stress tests performed igzo tfts using various bending radii directions order examine instability characteristics tfts addition degradation mechanisms investigated using technology computer aided design simulation result demonstrated possible establish reliable circuit guidelines using igzo tfts foldable display applications
recently research cultural groups gradually becomes new focus midst study disabled culture typical example going perspective paper mainly summarizes influence physical appearance interpersonal space distance paralanguage etc disabled nondisabled people communication analyzes cultural foundations based hofstede theory value orientations finally communication principles proposed purpose improve intercultural communication disabled nondisabled people
objective compare physical activity bouts sedentary videogaming svg active videogaming avg paced walking children without autism spectrum disorder asd determine effectiveness avg providing moderate vigorous physical activity materials method participants included nine males years old asd eight age matched males typically developing groups anthropometric motor proficiency movement assessment battery children measures taken testing participants attended three randomly assigned acquisition sessions minutes paced walking metabolic equivalents avg svg videogaming occurred xbox kinect actical accelerometer provided activity counts percentage time moderate vigorous physical activity mvpa compared using repeated measures analysis variance measure results main effects conditions existed mvpa post hoc bonferroni comparisons indicated avg significantly higher mvpa svg significantly lower paced walking mvpa overall participants spent time mvpa avg compared paced walking svg main effects groups group condition interaction effects found either measure conclusions avg may provide appealing means individuals increase overall physical activity levels although avg seen replacement walking forms although research necessary finding groups performed similarly avg suggests games potentially played without modifications adaptations gaming units may provide several advantages terms social cost ease accessing unit
hereditary angioedema hae rare disorder resulting decreased functional levels inhibitor inh manifests periodic episodes localized edema extremely painful debilitating even fatal swelling affects larynx hae complicate many aspects obstetric gynecologic care awareness disease critical clinicians involved care women potential hae related complications pertaining pregnancy labor delivery women health issues article provides review published literature specific hae management female patients including important concerns regarding obstetric gynecologic care growing body relevant experience presented help guide care women hae
ambient intelligence aml worlds consist heterogeneous collections interconnected devices integrate smoothly environment offer services users devices added change fail modifying system topology also circumstances may change affecting users activities time location presence users changes modify information system available satisfy users needs context aml systems need adapt evolving conditions order able provide services unobtrusive possible users also performance requirements system must fulfill provide responses environment stimuli real time opportunistic control mechanisms address issues monitoring context suspending resolving goals appropriate conditions met paper presents faerie software framework supports development aml applications facilities context management rely opportunistic control development faerie systems uses simulator tool testing validation called ubiksim case study artistic installation illustrates use infrastructure elsevier ltd rights reserved
melanopsin opn specialized photopigment responsive especially blue light wavelengths found human brain protein level outside retina specifically opn found retinal ganglion cells intrinsically photosensitive retinal ganglion cells subtype retinal cone cells given allen institute brain science described wide distribution opn mrna two human brains aimed investigate whether opn present human brain also protein level western blotting immunohistochemistry well immunoelectron microscopy used analyse existence distribution opn protein investigated areas human brain samples obtained forensic autopsies male subjects years opn protein expression found subjects furthermore subjects investigated brain areas localized membranous compartments cytoplasmic vesicles neurons opinion wide distribution opn central areas human brain evokes question whether ambient light important straight targets human brain outside retinohypothalamic tract rht studies however needed investigate putative physiological phototransductive actions inborn opn protein outside rht human brain
irritable bowel syndrome ibs heterogeneous patients need proper assessment explanation ibs pathophysiology appropriate therapies low fodmap fermentable oligosaccharides disaccharides monosaccharides polyols diet effectively reduces symptoms patients best treatment nonresponsive depend pathophysiological basis symptom genesis following possible abnormalities visceral hypersensitivity enhanced gut brain communication low fodmap diet mainly targeted patient group dietitian may also recommend antispasmodic agents including peppermint oil another dietary treatment low food chemical diet although diet often extremely limited therefore suited populations psychological therapies also clinically beneficial altered motility patients fast transit dietitian may recommend reduction fodmaps targeted monosaccharides disaccharides osmotic nature effective patients may benefit psyllium exceptional water holding capacity aimed promote formed stools patients slow uncoordinated transit often difficult treat dietary interventions success usually comprise combination adequate fiber fluid osmotic laxatives stimulating agents caffeine senna exercise iii altered microbiome supplementary probiotics prebiotics weak evidence efficacy notable exceptions dietitian may trial supplementary bifidobacterium infantis oligosaccharides usually adjunct therapy guidance dietitian encompass dietary methods treat ibs additionally identify dietary treatment indicated ensure diet correctly used patients nutritionally psychologically compromised
success cartilage fibrocartilage tissue engineering relies heavily using appropriate cell source many different cell sources identified including primary stem cells along experimental strategies obtain required number cells induce chondrogenesis however definitive method exists quantitatively evaluate similarity resulting cell phenotypes native cells candidate strategies study develop integrative approach enable evaluations deriving gene expression profiles two quantitative metrics representing nearest location within range native cell phenotypes deviation example application evaluating potential cell sources cartilage meniscus tissue engineering examine phenotypic changes juvenile adult articular chondrocytes fibrochondrocytes across multiple passages subsequent culture substantial change observed cell phenotype due isolation process followed clear progression toward outer meniscal cell phenotype passage new metrics also indicated culture moderately reduced passage induced deviation native meniscal phenotypes juvenile chondrocytes adult fibrochondrocytes obvious examination individual gene expressions however brief culture alone move cells towards inner meniscal phenotype relevant target meniscal tissue engineering integrative approach examining combining multiple gene expressions used evaluate various tissue engineering strategies direct cells toward desired phenotype copyright john wiley sons ltd
healthcare disparities represent differential treatment patient race experience bias within medical system ways accounted medical factors systematically contribute relatively poor health members stigmatized groups internationally focus bias healthcare experienced blacks relative whites usa practically disparities significant socially consequential empirically disparities comprehensively documented studied specifically describe nature extent racial bias among healthcare providers examine effects biases treatment behavior toward black patients responses perceptions black patients suggest ways reducing negative effects racial bias healthcare although physicians generally inhibit direct effects conscious explicit bias healthcare provide implicit bias independently combination explicit attitudes plays influential role dynamics physicians healthcare interactions black patients producing lower quality care identify several theory based interventions limit potentially eliminate negative consequences provider biases within medical context recognizing active roles providers patients exchanges
masquerade syndromes present uveitis clinics due appearance inflammatory signs chronic symptoms responsive conventional treatment frequently misdiagnosed treated refractory inflammatory conditions delays appropriate diagnosis management review literature focuses commonly encountered masquerade syndromes discusses role multimodal imaging addressing complex clinical presentations review conventional imaging techniques patients discuss emerging technological advances may help establishing diagnosis present cases highlighting utility multimodal imaging identifying etiology
article describes court improvement initiative designed promote uniformity improved court practice ultimate goal improvement outcomes children families article focuses results interviews focus groups conducted part evaluation initiative twelve jurisdictions purposively selected exhibit range family court non family court jurisdictions rural middle sized locations discussion qualitative results focuses changes court practice impact initiative case time key points family court community initiative undertaken promote consistency practice family law matters explain rules impact following areas divorce property distribution result divorce custody visitation child support adoption termination parental rights domestic violence child abuse neglect status offenses describe impact state wide court improvement initiative identify areas improvement within court operations may modified jurisdictions
background mouse urodynamic tests fundamental understanding normal lower urinary tract lut function experiments also contribute understanding neurological dysfunction pathophysiological processes potential mechanisms therapy objectives systematic assessment published evidence urodynamics advantages limitations different urodynamic measurements mice consideration potential implications clinical field methods search using specific search terms urodynamic studies mice conducted pubmed inception july results identified studies examining describing mouse neuro urodynamics summarize reported features mouse urodynamic function deriving frequency volume chart fvc measurements voiding spot assays filling cystometry pressure flow studies similarly influence diurnal cycle voiding observed mice considered interpreting rodent urodynamic studies especially fvc measurements voiding spot assays anaesthesia restraint conditions filling rate influence mouse neuro urodynamics mouse cystometric studies observed intravesical pressure oscillations accompany urine flow attributed high frequency opening closing urethra characterization seen species except rats contrast human clinical urodynamics terminology examinations standardized although many rodent urodynamic studies described conclusion mice many anatomical physiological similarities humans generally cost effective allow investigation effects aging short lifespan differences mouse human urodynamics must considered interpreting lut function mice translational value murine disease models
background many patients suffer hospital cardiac arrest fail receive bystander intervention cardiopulmonary resuscitation cpr defibrillation despite widespread cpr training dissemination automated external defibrillators aeds sought investigate factors encourage lay bystanders initiate cpr aed use cohort bystanders previously trained cpr techniques present hospital cardiac arrest methods results one hundred twenty eight semistructured qualitative interviews cpr trained lay bystanders consecutive hospital cardiac arrest aed present conducted january april denmark purposive maximum variation sampling used establish breadth bystander perspective twenty six interviews chosen depth analyses data saturation used cross sectional indexing using software inductive depth thematic analyses identify factors facilitated cpr aed use addition prior hands cpr training following described facilitators prior knowledge intervention crucial improving survival cause substantial harm aed provide guidance cpr prior hands training aed use cpr performance teamwork support using aed voice prompt ventilation mask well demonstrating leadership feeling moral obligation act conclusions several factors previous hands cpr training facilitate lay bystander instigation cpr aed use recognition modification factors may increase lay bystander cpr rates patient survival following ofhospital cardiac arrest
background aetiology angio oedema difficult determine however essential emergency situations two major contexts may present mast cell mediated bradykinin mediated different forms currently distinguished based clinical criteria spontaneous duration attack presence concomitant late appearing superficial urticaria history atopy others specific biomarkers could improve patient management objective prospective study potential biomarkers identified statistical characteristics examined methods samples taken day patient groups bradykinin mediated peripheral site attack ear nose throat ent abdominal involvement mast cell mediated non bradykinin mediated abdominal pain results assay potential biomarkers revealed significant differences inhibitor levels contrast dimer levels peaked bradykinin mediated attacks median well mast cell mediated attacks high bradykin inmediated compared control group threshold value found negative predictive value bradykinin mediated compared causes abdominal pain group circulating cadherin levels also increased attack could distinguish bradykinin mediated mast cell mediated like dimers conclusions exploration changes fibrinolysis related markers particularly dimers thus promising diagnosis attacks difficult diagnose abdominal forms although able differentiate bradykinin mast cell mediated karger basel
developing simulation program use soil wheel interaction problems coupling finite element method fem discrete element method dem wheel modeled fem soil expressed dem previous two dimensional dem updated analyze tractive performance flexible elastic wheel introducing new algorithm learned pid controller model elastic wheel model four structural parts defined using fem wheel rim intermediate part surface layer wheel lugs wheel rigidity controlled varying young modulus intermediate part tractive performance two elastic wheels lugs planetary rovers european space agency analyzed numerical results compared experimentally obtained results collected dlr bremen germany dem result confirmed depict similar behaviors tractive performance gross tractive effort net traction running resistance wheel sinkage results experiments moreover tractive performance elastic wheels mars predicted using dem results clarified significant difference net traction exists two wheels istvs published elsevier ltd rights reserved
maladaptive self criticism associated diminished goal progress present study examined impact failure success experiences performance working memory measures order gauge goal directed performance participants varying levels self criticism completed baseline working memory task randomly assigned success failure feedback manipulation separate task followed second working memory measure results demonstrated varying feedback dependent test retest performance across levels self criticism low self critics differ test retest scores across feedback conditions failure resulted decrease performance moderate self critics increased performance high self critics conversely success moderate self critics displayed increase high self critics displayed decrease performance retest findings shed light varying perceptions responses failure versus success across levels self criticism important implications factors impact motivation goal directed performance elsevier ltd rights reserved
paper dynamic response cable stayed bridge loaded train moving forces stochastic velocity investigated cable stayed bridge modelled rayleigh beam linear elastic supports stochastic melnikov method derived mean square criterion used determine effects stochastic velocity cables number threshold condition inhibition smale horseshoes chaos system results indicate intensity random component loads velocity contributed enlargement possible chaotic domain system increases chances regular behavior system hand presence cables cable stayed bridges system increases degree safety paradoxically contributed destabilization numerical simulations governing equations carried confirm analytical prediction effect loads number system response also investigated elsevier ltd rights reserved
psoriatic skin laminin integrity altered could lead insufficient laminin integrin interactions leaving integrin exposed possibly accessible autoantibody production therefore investigated presence anti integrin autoantibodies serum patients psoriasis vulgaris psoriatic arthritis psa rheumatoid arthritis comparison healthy donors level circulating anti integrin antibodies determined enzyme linked immunoassay using integrin fragments antibodies least one recombinant fragment found approximately psa patients contrast patients frequency antibodies similar healthy controls study shows presence anti integrin antibodies psa could indicate ongoing abnormal processes skin anti integrin autoantibodies may contribute formation micro wounds skin characteristic wound healing phenotype psoriasis
backgroundmany mood disorder patients need analgesics due increased pain sensitivity recent studies suggested nonsteroidal anti inflammatory drugs nsaids may inhibit antidepressant treatment requires replication clinical recommendations methodsthe clinical health outcomes initiatives comparative effectiveness bipolar disorder study randomized participants months lithium quetiapine treatment use nsaids paracetamol assessed throughout study period psychopathology measured clinical global impression scale bipolar disorder cgi bipolar inventory symptoms scale biss effects nsaids paracetamol treatment outcome examined using mixed effects linear regression adjusted age gender body mass index smoking status exercise somatic diseases resultsamong participants used nsaids paracetamol study nsaid paracetamol users differ nonusers respect treatment outcome lithium quetiapine time point months treatment overall cgi biss cgi subscales depression mania users nsaids paracetamol users nsaids paracetamol showed statistical difference compared nonusers conclusionsthis first trial show use nsaids paracetamol alone combination affect lithium quetiapine based bipolar disorder mood stabilizing treatment outcomes prior studies suggested nsaids may inhibit antidepressant treatment whereas results support findings indicating detrimental effects nsaids paracetamol affective disorder treatment
background aims root hydraulic limitations intra plant restrictions water movement may related crop performance drought groupings hydraulic function drought tolerant drought susceptible rice oryza sativa varieties previously reported study aimed better understand environmental physiological relationships rice root hydraulics drought methods xylem sap bleeding rates field sap shoot measured seasonal diurnal time frames time environmental conditions monitored physiological measurements conducted complementary experiments effects vapour pressure deficit vpd root hydraulic conductivity transpiration rates rooted tillers conducted growth chambers key results diurnal effects bleeding rate closely related irradiance vpd vpd effects root hydraulic conductivity measured day old plants due effects plant growth including root surface area maximum root depth root shoot ratio leaf osmotic potential related grouping drought tolerant drought susceptible varieties rice root hydraulics groupings independent differences phenology low single tiller bleeding rates observed high evapo transpirational demand higher bleeding rates observed negative leaf osmotic potentials drought susceptible varieties drought tolerant susceptible varieties differed vpd induced increase transpiration rates rooted tillers low root suberin amounts drought susceptible varieties may resulted higher ion transport evidenced higher sap concentration higher bleeding rates varieties conclusions results provide evidence environmental effects shoots influence root hydraulics consistent groupings drought tolerant susceptible varieties suggest traits affecting plant osmotic status may regulate root hydraulic response drought rice
primary care practitioners pcps playing increasingly important role management care psoriasis thus important pcps knowledgeable disease able differentiate common myths facts related diagnosis treatment building relationships patients working collaboratively dermatology health professionals specialists pcps facilitate communication patient treatment preferences expectations symptom relief may better able work patient optimize treatment adherence review aims provide pcps primer psoriasis associated comorbidities impact patients quality life discussion topics include psoriasis epidemiology triggering factors clinical presentation differential diagnosis comorbidities approaches treatment review also highlights importance staying abreast advances understanding psoriasis pathogenesis well emerging therapeutic treatment options advances may change treatment landscape increase patients expectations skin clearance
inconsistent social behavior core psychopathological feature borderline personality disorder goal present study examine inconsistency social decision making using simple economic social experiments investigated decisions female patients bpd patients major depressive disorder mdd healthy controls three single shot economic experiments measuring trust cooperation punishment bpd severity assessed using zanarini rating scale bpd investments across identical one shot trust punishment games significantly inconsistent bpd patients controls inconsistencies found social risk conditions trust punishment conditions non social control conditions mdd patients show inconsistencies furthermore social support negatively correlated inconsistent decision making trust punishment game underscores clinical relevance finding elsevier ireland ltd rights reserved
field programmable analog array fpaa computational analog blocks cabs occupying cmos presented cab wide variety subcircuits ranging granularity multipliers programmable offset wide linear range blocks nmos pmos transistors programmable interconnects circuit elements cab implemented using floating gate transistors total number exceeds fifty thousand using devices eliminates need sram store configuration bits since switch stores configuration system exhibits significant performance enhancements predecessor terms achievable dynamic range voltage speed approximate gates accurate current programming isolation switches improved routing fabric designed includes nearest neighbor connections minimize penalty bandwidth due routing parasitic maximum bandwidth mhz switch matrix around mhz first order low pass filter achievable chip limitation program mode switch rectified next chip programming performance improved drastically implementing entire algorithm chip spi digital interface measured results individual subcircuits two system examples including receiver speech processor presented
existing vibration isolators dampers based magnetorheological materials need electrical power feed magnetic coils stimulate material loss power strong earthquake system failure unable protect structure paper outlines design test controllable multilayered magnetorheological elastomer mre isolator based circular dipolar halbach array set magnets generates strong uniform magnetic field combining mre layered isolator system halbach array allows constant vibration isolation low power consumption power generated used adjust halbach position system tested successfully altered lateral stiffness damping force respectively paper also includes extended analysis magnetic field generated circular dipolar halbach array discussion improvements may potentially improve range magnetic fields generated
rainwater harvesting rwh could best alternative water resources affects yield productivity sorghum sorghum bicolor therefore field studies conducted north kordofan area western sudan sandy clay loam soil growing seasons effects five water harvesting techniques whts growing sorghum including mulching intercropping stone barriers crescent shape investigated moisture content soil measured three periods crop sowing mid season harvest four soil depths results revealed soil plant parameters significantly influenced whts growing seasons improving structure infiltrability water storage capacity soil relation control variability soil moisture content smc plant parameters increased drier season decreased wetter season soil depth measurement period interaction highly significant effects smc growing seasons differences among whts obvious topsoil layer significant differences depth straw mulching conserved moisture within one soil profile particularly medium lower depths also consistently captured run water techniques stages plant growth growing seasons followed earth stone bunding clearly reflected better crop establishment yield components sorghum hence generate higher gross returns conclusion study revealed potential advantages whts semi arid zones particularly northern kordofan sudan reference rationale adopting whts enhance sorghum yield
feeding interactions among functional feeding groups ffgs macroinvertebrates robust indicators aquatic ecosystem interactions provide information regarding organic matter processing habitat condition trophic dynamics tropical rivers pronounced wet dry seasons macroinvertebrate based ecological monitoring tools explicitly focused metrics indices ignoring interactions ffg therefore objective study investigate functional feeding type metrics diversity indices feeding interactions among ffg macroinvertebrates along water pollution gradient gilgel gibe watershed ethiopia water quality parameters macroinvertebrate community attributes assessed samples collected upstream sites sites urban impacted stretches sites wetland affected river zones sites watershed rainy july dry february seasons understand effect pollution feeding interactions stable carbon nitrogen isotopes analyzed macroinvertebrate based diversity indices functional feeding type metric showed deterioration ecological integrity urban impacted sites substantial recovery wetland affected downstream sites omnivorous feeding behavior macroinvertebrates noted upstream sites whereas clear trophic guilds ffg suggested wetland affected river zones stable isotope results results pollution gradient analysis feeding interactions among ffgs revealed urban impacted sites showed weaker interactions compared upstream wetland influenced sites affirms potential importance feeding interactions among ffgs macroinvertebrates water quality monitoring elsevier gmbh rights reserved
tissue microenvironment functions crucial player carcinogenesis transforming growth factor beta colorectal cancer tgf beta within microenvironment stimulates formation neoplasms using vitro model malignancy induced tgf beta assessed effect evodiamine berberine interaction dna methyltransferases dnmts target micrornas mirnas model colon tissues neonatal rats days age cultured malignancy induced tgf beta vitro tissues respectively treated evodiamine berberine morphological alteration tissues observed using hematoxylin eosin staining expression levels dnmts targeted mirnas screened bioinformatics software combined gene chip analysis previous study detected immunohistochemistry quantified real time pcr twenty four hours treatment tgf beta expression levels dnmt dnmta dnmtb mir target dnmt mir target dnmta mir target dnmta markedly decreased however expression levels dnmt dnmta significantly increased target mirnas still decreased treatment dnmt inhibitor aza expression levels mirnas increased larger extent reach normal levels treatment berberine evodiamine respectively increased expression dnmt dnmta dnmtb mir mir mir noted conclusion results present study suggest mirnas also post transcriptionally regulated corresponding dnmts berberine evodiamine regulate expression genes provides early epigenetic evidence prevention therapy colorectal cancer
paper analyze direction arrival doa ice sheet data collected jakobshavn glacier airborne multichannel radar depth sounder mcrds field season extracted weak ice bed echoes buried signals scattered rough surface fast flowing jakobshavn glacier analyzing doa signals received five element receive antenna array allowed obtain ice thickness information key parameter generating bed topography glaciers also estimated ice bed roughness bed slope combined analysis doa radar waveforms bed slope degrees roughness terms rms slope degrees
traditional prehospital management trauma victims potential spinal injury become increasingly questioned authors clinicians raised concerns triage harm order address concerns norwegian national competence service traumatology commissioned faculty provide national guideline pre hospital spinal stabilisation work based systematic review available literature standardised consensus process faculty recommends selective approach spinal stabilisation well implementation triaging tools based clinical findings strategy minimal handling observed
forensic tools assist analysts recovery data system events even corrupted storage tools typically rely file carving techniques restore files metadata loss analyzing remaining raw file content significant amount sensitive data stored processed relational databases thus creating need database forensic tools extend file carving solutions database realm raw database storage partitioned individual pages read presented analyst without help database furthermore directly accessing raw database storage reveal things normally hidden database users exists number database specific tools developed emergency database recovery though usually forensic analysis database paper present universal tool seamlessly supports many different databases rebuilding table data content remaining storage fragments disk memory define approach automatically minimal user intervention reverse engineering storage new databases detecting volatile data changes discovering user action artifacts finally empirically verify tool ability recover deleted partially corrupted data directly internal storage different databases authors published elsevier ltd behalf dfrws open access article license http creativecommons org licenses
ease programming burden make parallel programs maintainable computational scientists engineers currently options use software libraries templates general purpose language extensions compose application programs existing options unfortunately considerable limitations compatibility expressive power delivered performance address issues design domain specific language gridfor computational problems defined regular geometric grids language allows programmer first implement algorithm simple data structures commonly illustrated textbooks papers programmer specifies transformations extend algorithm complex data structures required target applications build compiler automatically translate gridfor program parallel fortran version message passing interface calls several optimization techniques implemented compiler enhance program speed
alcohol dependence causes physical social moral harms currently represents important public health concern according world health organization alcoholism third leading cause death worldwide tobacco consumption hypertension recent epidemiologic studies shown growing trend alcohol abuse among adolescents characterized consumption large doses alcohol short time period since brain development ongoing process adolescence short long term brain damage associated drinking behavior could lead serious consequences health wellbeing accumulating evidence indicates alcohol impairs function different components melanocortin system major player involved consolidation addictive behaviors adolescence adulthood hypothesize possible implications melanocortins glial cells onset progression alcohol addiction particular propose alcohol induced decrease alpha msh levels may trigger cascade glial inflammatory pathways culminate altered gliotransmission ventral tegmental area nucleus accumbens nac latter might potentiate dopaminergic drive nac contributing increase vulnerability alcohol dependence addiction adolescence adulthood
objective elevated levels tumor necrosis factor alpha tnf alpha capsule temporomandibular joint tmj implicated underlying pathology temporomandibular disorders tmd tmd group conditions result pain tmj muscles mastication associated significant social economic burdens goal study investigate effect elevated tnf alpha levels tmj capsule nocifensive behavioral response mechanical stimulation trigeminal neurons regulation cytokines within trigeminal ganglion design male sprague dawley rats injected bilaterally tmj capsule tnf alpha changes nocifensive head withdrawal responses mechanical stimulation cutaneous tissue directly capsule determined using von frey filaments cytokine levels trigeminal ganglia determined protein array analysis several time points post injection correlated nocifensive behavior results tnf alpha caused significant increase average number nocifensive responses compared naive vehicle treated animals post injection levels returned control levels based array analysis levels eight cytokines significantly elevated vehicle control levels following tnf alpha injection eight returned vehicle control levels conclusions findings provide evidence elevated levels tnf alpha joint capsule reported occur tmd promotes nociception trigeminal ganglia neurons via mechanism temporally correlates differential regulation several cytokines elsevier ltd rights reserved
evolution procedure fitness distribution population always unforeseeable since varies many factors nonlinearity multimodality optimization problem crossover mutation algorithms progress evolution procedure gas using stochastic selection mechanisms fitness distribution sometimes significantly impacts performance selection process make ineffective protecting superior individuals preventing inferior individuals study new fitness scaling method named powered distance sums scaling pdss proposed eliminate influence fitness distribution stochastic selection unlike previous approaches new method uses powered sums fitness distance substitute raw fitness values ranking numbers computing scaled fitness maintains much constant consistent selective pressure different conditions optimization problem algorithm design may help designers balancing exploration exploitation evolution procedures empirical studies employed illustrate new method using new scaling technique convergence speed search becomes controllable elsevier rights reserved
human identification distance recently become hot research topic fields computer vision pattern recognition since gait patterns operate distance without subject cooperation gait recognition widely studied address problem paper subspace ensemble learning using totally corrective boosting sel tcb framework kernel extension proposed gait recognition framework multiple subspaces iteratively learned different weight distributions triplet set using totally corrective technology order preserve proximity relationships among instance triplets extend sel tcb framework kernel sel tcb ksel tcb framework deal nonlinear manifold data compare method recently published gait recognition approaches usf humanid database experimental results indicate proposed method achieves highly competitive performance state art gait recognition approaches
female participation work places increased last decades women make million seafarers worldwide international maritime organization imo international labor organizations making concerted effort promote women maritime industry still barriers maritime industry hinder female employment particularly leadership positions primary aim paper investigate whether significant difference implicit beliefs leadership males females addition seeks evaluate whether aforementioned difference within context masculine versus neutral work domains findings indicated employees maritime industry might lower expectations towards female leaders thereby indicating presence gender bias evaluation leaders
slca facilitates transport endogenous exogenous cationic compounds many pharmacologically significant compounds transported slca including antidiabetic drug metformin anticancer agent cisplatin antiretroviral lamivudine genetic polymorphisms slca modify pharmacokinetic profiles important medicines could therefore prove useful precision medicine biomarkers since frequency slca polymorphisms varies among different ethnic populations evaluated south african bantu speakers majority group south african population exhibit unique genetic diversity subsequently functionally characterized promoter polymorphisms identified polymorphisms within promoter single nucleotide polymorphisms snps within coding region slca polymorphisms appeared minor allele frequencies similar african non african populations differed considerably especially notable three missense polymorphisms addition functionally characterized two promoter polymorphisms three base pair deletion bioinformatics analysis suggested could alter ets elk stat binding snp could abolish tfii binding significantly higher luciferase reporter gene expression found increase significantly lower expression decrease comparison wild type control observations highlight importance identifying functionally characterizing genetic variation genes pharmacological significance finally data slca attest importance considering genetic variation different populations drug safety response global pharmacogenomics example projects human heredity health africa initiative
objective assess effect introducing consensus guidelines avoidable blood transfusions mwanza region tanzania methods avoidable blood transfusions determined among blood transfusion recipients eight hospitals workshop senior health workers region consensus guidelines prescription blood transfusions developed introduced hospitals months intervention data collected blood transfusion recipients data compared estimate change proportion avoidable blood transfusions results blood transfusion recipients aged years significant reduction proportion avoidable blood transfusions especially peripheral hospitals children proportion decreased operated patients percentage remained pregnant women significant increase proportion avoidable blood transfusions adults improvement peripheral hospitals offset similar deterioration referral hospital thus overall reduction achieved proportion avoidable blood transfusions conclusion development introduction consensus guidelines sufficient change prescribing practice proportion avoidable blood transfusions decreased hospitals compliance maintained regular clinic meetings strict supervision senior medical staff
starch digestion rate strongly related metabolic diseases obesity diabetes starchy foods always contain non starch components affect starch digestibility mixtures ungelatinized corn starch common non starch component pectin used investigate pectin effect starch digestibility rate evolution starch molecular structure digestion using amyloglu cosidase pancreatin whole molecule size distribution chain length distribution chains measured size exclusion chromatography fluorophore assisted carbohydrate electrophoresis digestion profiles changes molecular size distributions whole debranched digesta digestion show addition pectin significantly decreased starch digestion rates pectin change amylose amylopectin ratio digestion decreased digestion rate short amylopectin chains compared long ones visible spectral data suggested major contributor digestion rate change substantial pectin amyloglucosidase interaction suggests approach designing nutritionally beneficial starch based foods taking account interactions pectin digestive enzymes elsevier ltd rights reserved
context awareness key feature ubiquitous middleware mainly applied adapt services interfaces applications use ubiquitous features application context information personalize data queries recent topic computing still presents large number challenges one main gaps evidenced research field lack integration context information designed used ubiquitous middleware domain data frequently persisted relational databases integration necessary context used filter content query position paper presents motivational scenario clarifies necessity integration context used ubiquitous middleware relational data comparison state art field list research opportunities field proposal framework uses ontologies integrate context domain data modeled stored relational databases
study examined relationship child language skills parent child gestures youths without autism spectrum disorder asd diagnosis frequencies rates total gesture use well five categories gestures deictic conventional beat iconic metaphoric reliably coded collaborative tower hanoi task children asd lower peabody picture vocabulary test scores gestured less lower rates compared typically developing children gesture use unrelated vocabulary typically developing children positively associated vocabulary asd demographic correlates gesturing differed group gesture may point communication intervention families children asd
family structure cue stereotyping past reviews topic stereotypes parenthood divided update current understanding important question systematic review summarizes integrates body literature published stereotypes associated married divorced single step sex adoptive parents seventeen articles met inclusion criteria analysis final sample studies helps main trends pertaining six parental types identified findings revealed motherhood fatherhood continue conceptualized differently stereotypes associated different types fathers appearing positive associated different types mothers married parents also appear remain parental type positively stereotyped types compared results compared past meta analytic reviews implications future research presented
paper deals investigations integration renewable energy sources electrical network fact liberalization electricity market development decentralized production induce many scientific technical problems electrical engineering thus renewable energy production obvious problems come technology integrated electrical grid influence global management distribution system important make sure decentralized productions participate actively grid integration particular study networks highlighted paper integration particular wind turbine impact distribution network presented simulations scenarios systems carried matlab simulink
development computer network technology closely relationship people network current network security problem also gradually public field vision actively carried network intrusion detection becomes important direction development network security technology basis original neural network paper puts forward improved algorithm applied network intrusion detection test method better traditional convergence better performance
operating system essential operate computers normally computers come preloaded operating systems however often preloaded operating systems able fulfill requirements users users sometimes need change operating system based needs although comparative studies tools available operating systems still lack tools provide independent objective review recommendation help users understand select major operating systems paper propose tool called fsos analyses well known operating systems used domestic commercial industrial level suggest suitable operating systems users per requirements
automatic identification abnormal cervical cells including feature representation feature combination classification strategy highly demanded women annual cervical cancer screenings however previous methods deal one two three phases currently complete framework problem novel three phrase boosting framework proposed detection abnormal cells cervical smear images first authors extract dimensional features respect cervical cell three aspects including cytology morphology chromatin pathology region intensity particular dimensional chromatin pathology features newly adopted describe nucleus textural transformation second adaptive feature combination method introduced select optimal feature patterns combine features using reinforced margin based approach heuristic knowledge finally two stage classification strategy presented reduce erroneous classification abnormal cells using two different classifiers experimental results achieve state art performance proposed framework outperforms compared detection methods
present noncontact method measure ballistocardiogram bcg photoplethysmogram ppg simultaneously using single camera method tracks motion facial features determine displacement bcg extracts corresponding velocity acceleration bcgs taking first second temporal derivatives displacement bcg respectively measured bcg waveforms consistent reported literature also recorded accelerometer based reference method method also tracks ppg based reflected light facial region makes possible track bcg ppg optics verify robustness reproducibility noncontact method small pilot study subjects presented method first demonstration simultaneous bcg ppg monitoring without wearing extra equipment marker subject
memory diagnostics important improving resilience dram main memory bit cell size reaches physical limits dram memory likely suffer transient permanent errors memory diagnostics operate online component comprehensive strategy allay errors paper presents novel approach asteroid integrate online memory diagnostics workload execution approach supports diagnostics adapt runtime workload behavior resource availability maximize test quality reducing performance overhead describe asteroid design efficiently integrated hierarchical memory allocator modern operating systems also present framework enables control policies dynamically configure diagnostic using adaptive policy core server asteroid modest overhead workloads low high memory demand workloads asteroid adaptive policy good error coverage thoroughly test memory
paper describes early studies results design system supporting domain experts managing data streams coming set sensors services base ambient intelligence ami environments domain experts use proposed system creatively elaborate needs ideas type data flow generated monitoring emergency situations combining physical social sensors moreover conduct different analysis considering contextual information space time thematic
modeling propagation action potentials human atria various models developed past take account detail influence numerous ionic currents flowing cell membrane aiming simplified description bueno orovio cherry fenton bocf model electric wave propagation ventricle adapted recently atrial physiology study adapted bocf abocf model respect capability accurately generate spatio temporal excitation patterns found anatomical spiral wave reentry end compare results abocf model detailed one proposed courtemanche ramirez nattel crn model find characteristic features reentrant excitation patterns seen crn model well captured abocf model opens possibility study origins atrial fibrillation based simplified still reliable description
paper presents tribo dynamic model planetary gear sets hybrid electric vehicle configurations model comprises six degree freedom torsional multi body dynamic system well tribological contact model order evaluate lubricant film thickness friction efficiency meshing gear teeth contacts tribological model takes account non newtonian thermal mixed elastohydrodynamic regime lubrication analysis performed hybrid electric segment vehicle simulated conditions correspond cases power supplied either engine electric motor results illustrate electric motor drive mode improved noise vibration harshness refinement would expected whereas better transmission efficiency achieved internal combustion engine drive mode
research last two decades role positive emotions cognitions psychological functioning leading conceptual changes regarding nature mental disorders mechanisms underlying onset maintenance introduction latest breakthrough research positive emotions cognition offers brief description emerging presence positivity current diagnostic systems like dsm research domain criteria rdoc also analyzes select findings literature experimental psychopathology supporting relevance examining positive aspects functioning clinical psychology addition study positive aspects psychological functioning adds conceptually complex understanding psychopathology multiple perspectives encompassed special issue shed light understanding different roles positive emotions cognitions play mediating normal abnormal human functioning importance improving research methods interventions psychopathology
atomic force microscopy afm powerful characterization tool widely applied problems large range disciplines natural sciences including cellular biology used obtain information morphological changes induced erythrocyte membrane patients epilepsy undergo long time treatment operates upon one several neuronal ionic channels comparative healthy donor technique allowed non invasive imaging erythrocyte membrane revealing details specific characteristics nanometer level characterization surface texture parameters average height average roughness coefficient kurtosis micrometer nanometer resolution healthy donor afm morphology appears characteristics normal red blood cell membrane instead closer examination erythrocytes membrane surface morphology samples collected patients diagnosed epilepsy treated specific drugs reveal similar structures obtained healthy donor nanostructure membrane drastically damaged depending administrated treatment probably time affect functionality therefore anticomital drugs influence neuronal level also red blood cell level
objective evaluate whether age disease presentation helps better characterize disease phenotype psa methods retrospective cohort study included consecutive patients fulfilling caspar criteria psa study outcomes assessed using univariate multivariate analyses according age onset skin joint disease cut years results early onset psoriasis eop showed extensive skin involvement axial pattern disease onset mixed pattern evolution family history psoriasis psa higher prevalence hla hla early onset arthritis eoa family history psa hla positivity patients late onset arthritis loa likely hypertension dyslipidemia obesity late onset psoriasis lop tended obesity hypertension ischemic heart disease follow multivariate analysis lop predicted development loa shown independent risk factor hypertension conclusion age disease onset exerts strong influence several domains disease phenotype psa therefore descriptor considered good stratification option epidemiological genetic studies psa societe francaise rhumatologie published elsevier masson sas rights reserved
floating oscillating bodies constitute important class offshore wave energy converters testing power take equipment pto high pressure hydraulics linear electrical generator realistically simulated sea conditions usually regarded major task laboratory rig consisting tube enclosing oscillating column water driven time varying air pressure devised simulate hydrodynamics oscillating buoy absorbing energy sea waves especially inertia resonant frequency oscillating body pto force applied means piston one ends tube oscillating water column whereas end subject controlled time varying air pressure found provide reasonably realistic way testing pto system including control adequate scale say would avoid use much expensive experimental facility large wave tank testing real wind generated sea waves matching conditions tube geometry driving time varying air pressure must meet ensure adequate simulation derived conditions leave freedom tube rig designer operator allowing practical engineering issues taken account elsevier ltd rights reserved
backgroundall trans retinol precursor retinoic acid effective anti aging treatment widely used skin care products comparison topical retinoic acid believed provide even greater anti aging effects however limited research directly comparing effects retinol retinoic acid skin objectivesin study compare effects retinol retinoic acid skin structure expression skin function related genes proteins also examine effect retinol treatment skin appearance methodsskin histology examined staining invivo confocal microscopy expression levels skin genes proteins analyzed using pcr immunohistochemistry efficacy retinol formulation improving skin appearance assessed using digital image based wrinkle analysis resultsfour weeks retinoic acid retinol treatments increased epidermal thickness upregulated genes collagen type cola collagen type cola corresponding increases procollagen procollagen iii protein expression facial image analysis showed significant reduction facial wrinkles following weeks retinol application conclusionsthe results study demonstrate topical application retinol significantly affects cellular molecular properties epidermis dermis shown skin biopsy noninvasive imaging analyses although magnitude tends smaller retinol induces similar changes skin histology gene protein expression compared retinoic acid application results confirmed significant facial anti aging effect observed retinol efficacy clinical study
strong evidence poverty economic disadvantage associated child maltreatment however research area underdeveloped canada purpose paper examine relationship economic hardship maltreatment families children identified ontario child protection system maltreatment concern secondary analyses ontario incidence study reported child abuse neglect ois conducted ois examines incidence reported maltreatment characteristics children families investigated child welfare authorities ontario descriptive bivariate chi square analyses conducted addition logistic regression predicting substantiation maltreatment investigations household run money food housing utilities past months children households likely developmental concerns academic difficulties caregivers mental health concerns substance use issues controlling key clinical case characteristics children living families facing economic hardship almost times likely involved substantiated maltreatment investigation implications regard future research promoting resilience discussed
objectiveour aims investigate relationship food addiction mental disorders including eating disorders eating related psychopathology body mass index standard deviation score sample adolescent psychiatric inpatients methodsfood addiction assessed yale food addiction scale yfas eating related psychopathology measured three factor eating questionnaire tfeq psychiatric diagnoses assessed according diagnostic statistical manual mental disorders fourth edition sample consisted adolescent psychiatric inpatients met criteria multiple regression analysis used examine association yfas symptom count tfeq scales controlling age gender resultsfood addiction frequency mean yfas symptom count patients food addiction tfeq scale scores significantly higher patients without food addiction frequency patients patients without food addiction tfeq subscales disinhibition hunger well diagnosis associated yfas symptom count discussionfood addiction adolescent psychiatric inpatients occurs rates higher seen community samples children adolescents adults food addiction might associated eating styles related susceptibility hunger feelings loss control implications high yfas scores restricting type anorexia nervosa warrant investigations explore respective items interpreted subgroup copyright john wiley sons ltd eating disorders association
light primary signal calibrates circadian neural circuits thus coordinates daily physiological behavioral rhythms solar entrainment cues drosophila mammalian circadian circuits consist diverse populations cellular oscillators exhibit wide range dynamic light responses periods phases degrees synchrony heterogeneous circadian circuits generate robust physiological rhythms remaining flexible enough respond synchronizing stimuli long remained enigmatic cryptochrome short wavelength photoreceptor endogenously expressed approximately half drosophila circadian neurons previous study physiological light response measured using real time bioluminescence recordings drosophila whole brain explants remain intrinsically light sensitive apply analysis real time bioluminescence experimental data show detailed dynamic ensemble representations whole circadian circuit light entrainment single neuron resolution organotypic whole brain explants either maintained constant darkness days exposed phase advancing light pulse second day find stronger circadian oscillators support robust overall circuit rhythmicity whereas weaker oscillators pushed toward transient desynchrony damped amplitude facilitate new state phase shifted network synchrony additionally use mathematical modeling examine network composed distinct oscillator types give rise complex dynamic signatures conditions response simulated light pulses simulations suggest complementary coupling mechanisms combination strong weak oscillators may enable robust yet flexible circadian network promotes synchrony entrainment complete understanding properties oscillators signaling mechanisms facilitate distinct roles light entrainment may allow direct augment circadian system speed recovery jet lag shift work seasonal affective disorder
article presents version textile sand piles application road construction road bases arranged saline soils construction roads areas saline soils occurrence complex multidimensional problem includes study soil properties conditions education taking account specific features road constructions features excavation production technology case preservation saline soils subgrade required provide stability reduce time accumulation possible drafts road structure practice conditions realized use design technological solutions namely sand piles devices slots horizontal surface pillows precast reinforced concrete piles flexible raft geotextile vertical crushing drainage strips mounds polystyrene plates soil concrete piles well strengthening implementation deep saline soils mechanical mixing binders calculation developed roadbed construction using textile sand piles reduce cost timing road construction saline soils made authors published elsevier ltd
epidermal derived alarmins high mobility group box hmgb protein interleukin upregulated patients atopic dermatitis however capacity pro inflammatory cytokines derived effects skin barrier regulation poorly elucidated investigated impact hmgb gene transcription protein expression epidermal differentiation across distinct keratinocyte vitro models primary keratinocytes healthy donors used submerged monolayer cultures human epidermis equivalents human skin equivalents keratinocyte models underwent stimulation hmgb using positive control regulation vehicle negative control found hmgb downregulated transcription several genes members epidermal differentiation complex including filaggrin furthermore hmgb downregulated expression encoded proteins upper epidermis finally hmgb ultimately led impaired epidermal growth maturation conclusion hmgb could play significant role atopic dermatitis pathophysiology due negative regulation structural proteins stratum corneum formation epidermal growth
paper efficiency using vns variable neighborhood search algorithm forming four member heterogeneous groups within cscl computer supporting collaborative learning analyzed mathematical model based kagan instructions created vns algorithm metaheuristic solving mathematical optimization problems applied model proposed vns method tested set problem instances results compared optimal results obtained cplex solver applied proposed formulation vns method showed better performance terms execution time able solve large problem instances cscl applied three groups first year college students consisting students three groups divided smaller ones four students using vns algorithm group using kagan instructions group randomly group students tested cscl calculus contents statistical analysis shows students divided vns algorithm significantly better results students divided randomly students divided vns algorithm successful students divided without computer means students learning achievement calculus contents better divided vns randomly successful cooperative learning heterogeneous groups vns applied elsevier ltd rights reserved
loss nigral dopaminergic neurons typical parkinson disease responsible hyperexcitability medium spiny neurons resulting abnormal corticostriatal glutamatergic synaptic drive considering neuroprotective effect exercise changes promoted exercise ampa type glutamate receptors ampars role activity regulated cytoskeleton associated protein arc ampars trafficking studied impact short long term treadmill exercise evolution unilateral hydroxy dopamine ohda animal model wistar rats divided sedentary exercised groups without lesion ohda followed months exercised groups subjected moderate treadmill exercise week measured proteins tyrosine hydroxylase arc glua glua striatum substantia nigra motor cortex results showed higher reduction expression sedentary groups compared exercised groups striatum substantia nigra general larger changes occurred striatum first third months training month exercise significant increase glua concomitant reduction glua arc balanced system changes reversed third month showing increase arc glua decrease glua similar results gluas arc observed motor cortex exercised animals modifications may relevant corticostriatal circuits since exercise dependent plasticity modulate gluas expression maybe neuronal excitability
myelofibrosis bcr abl negative myeloproliferative neoplasm mainly characterised reactive bone marrow fibrosis extramedullary haematopoiesis anaemia hepatosplenomegaly constitutional symptoms leukaemic progression shortened survival malignancy still orphan curative treatments indeed treatment clearly demonstrated impact disease progression allogeneic haematopoietic stem cell transplantation minority patients eligible intensive therapy however recently discovery jak mutations also led development small molecule jak inhibitors first ruxolitinib approved treatment united states europe article report old new therapeutic strategies proved effective early preclinical clinical trials subsequently daily clinical practice patients particularly concerning topics anaemia splenomegaly iron overload allogeneic stem cell transplantation
objective study present offline control highly non linear inverted pendulum system moving plane inclined angle degrees horizontal stabilisation achieved using three different soft computing control techniques proportional integral derivative pid fuzzy logic adaptive neuro fuzzy inference system anfis matlab simulink model proposed system initially developed simulated using pid controllers based trial error method anfis controller trained using data sets generated simulation results pid controller anfis controllers designed using three membership functions fuzzy logic control proposed system also shown using nine membership functions study compares three techniques terms settling time maximum overshoot steady state error simulation results shown help graphs tables validates effectiveness proposed techniques
older adults prescribed sedative hypnotic medications higher rates younger adults recommended older adults due risk sedation cognitive impairment falls severe generalized anxiety disorder gad possibly appropriate use medications older people little available use sedative hypnotic medications among older adults gad study examined frequency predictors sedative hypnotic medication use among older adults screening positive anxiety participants reported taking sedative hypnotics past months reported taking benzodiazepines reported taking hypnotic sleep medications depressive symptoms strongly associated sedative hypnotic use insomnia worry major depressive disorder posttraumatic stress disorder gad predicted sedative hypnotic use medications treatments appropriate efficacious depression anxiety insomnia population
perceived ability cope trauma pact scale measures perceived forward focused trauma focused coping measure may also significant utility measuring positive adaption life threatening trauma combat objective examine perceived ability cope trauma measured pact relationships perceived ability clinically pertinent information anxiety depression posttraumatic stress disorder ptsd among military veterans data provided combat veterans consisting veterans ptsd veterans without ptsd subthreshold symptoms disorder veterans completed standardized clinical interviews well battery well validated self report symptom measures found veterans ptsd significantly lower pact scores veterans without ptsd without ptsd self reported ability engage forward focused trauma focused coping ptsd importantly also showed relationships pact scores indices psychological difficulties forward focus trauma focus coping scores negatively correlated ptsd depression anxiety alexithymia finally forward focus pact scale improved prediction ptsd severity combat exposure alone pact especially forward focus scale appears useful measure perceived positive coping ability trauma combat exposed veterans report symptoms traumatic stress extending utility measure normative clinical populations importance adopting forward focused coping discussed
objectives aims study compare contraceptive behaviour christian muslim adolescents abortion thrace greece examine whether extensive contraceptive counselling time abortion modified subsequent contraceptive practices methods adolescents aged years undergone elective abortion department included prospective year study extensive contraceptive counselling offered discharge hospital attitudes contraception assessed means simple questionnaire time abortion year follow results study population comprised christian orthodox adolescents group muslim adolescents group time abortion contraceptive behaviour differed significantly two groups contraceptive methods used group comparison group follows oral contraceptives condoms interrupted coitus periodic abstinence emergency contraception commonest source information contraception group gynaecologist family planning clinic whereas group individual partner parents contraceptive behaviour significantly modified groups post abortion follow original difference groups however persisted group oral contraceptives dominant method followed condoms whereas group order still reverse respectively conclusion cultural differences significantly affect contraceptive behaviour nevertheless interventions promote contraception still successful different populations
work meta models use design optimization low voltage motors investigated idea develop automated efficient methodology design optimization family electric motors widely adopted meta modeling algorithms examined concerns accuracy applicability design optimization motors meta model based optimization conducted case single motor two objectives another case group motors shared design variables cross section dimensions overall objective total material cost meta model based optimal designs verified real solver based optimization computational expense optimization simulations greatly reduced using meta models especially family design case neural network models give satisfactory optimization result among tested meta models terms accuracy variety outcome designs objective space work demonstrates great potential well challenge meta modeling technique use design optimization industrial products processes requirement accuracy reliability surrogate models high
paper postulates feasibility optimization hvac systems using programmable controllers hvac heating ventilating air conditioning systems used controlled maintenance indoor ambient characteristics optimal manner regards outdoor ambient characteristics paper includes simplified sequence diagrams represent architecture system also comprises systems software used also paper gives insight advantages using programmable controllers challenges overcome ease understanding case study pharmaceutical company given currently using system main purpose project create regulated monitoring system integration utilities like electricity water creating general report system given needed time span also create graphical visualization real time data system
chronic medical diseases evaluated several comorbidities indexes reported influence overall survival patients myelodysplastic syndrome mds however studies included patients lower higher risk disease ipss study retrospectively evaluates role comorbidities evaluated mds comorbidity index mds together clinical parameters series patients mds defined either ipss score low intermediate favorable cytogenetic categories ipss multivariate analysis together age years diabetes requiring therapy hemoglobin incorporation comorbidities mds independently associated probability nonleukemic death nld combination variables allowed development model categorizes patients three different groups significantly different probability nld overtime integrated score confirms importance comorbidities diagnosis patients mds
introduction aim study evaluate association breast cancer thyroid diseases many authors already studied possible relationship two diseases results nowadays conflicting materials methods study examining patients breast cancer women men average age years old also thyroid disease evaluated recurrence thyroid diseases association different types breast cancer statistical analyses performed using spss software windows used nonparametric tests chi square mannwhitney level significance set results found significant association breast cancer diagnosed menopause thyroid disease moreover analyzed role thyroid autoimmunity identifying association chronic autoimmune thyroiditis breast cancer diagnosed menopause regarding receptor profile breast carcinoma found increased expression estrogen receptors patients autoimmune thyroiditis compared patients thyroid diseases contrariwise found difference group every thyroid disease group without thyroid disease find statistically significant associations breast cancer parameters like family history tumor size lymph node metastasis distant metastasis cancer clinical pathological stage differentiation grade expression two main groups without thyroid disease likewise found statistically significant association hypothyroidism hyperthyroidism breast cancer
nineteen ent kaurane diterpenes isolated identified barks gochnatia decora kurz cabrera compositae used ethnic medicine treating cough asthma wounds southwestern china among six compounds previously undescribed ent kaurenoic acids known compound beta beta dihydroxy ent kaur oic acid obtained first time nature based traditional effects chinese folk potential anti inflammatory activities methanol extracts isolated diterpenes evaluated tests xyleneinduced ear swelling mice lipopolysaccharide lps induced nitric oxide production mouse macrophage cellular raw inhibition assay neutrophil elastase respectively resulting performed obvious effect mouse ear swelling dose dependent inhibition vivo nine compounds showed significant inhibition production vitro values ranging also exhibited inhibition neutrophil elastase vitro speculating diterpenes may active substances correlated traditional efficacy elsevier ltd rights reserved
chromosomal abnormalities encodes cell receptor alpha delta chain genes generally specific cell malignancies rarely reported malignancies report novel patient myelofibrosis following polycythemia vera year old male developed post years initial diagnosis normal karyotype polycythemic disease stage newly detected time fibrotic transformation therefore likely clonal chromosomal abnormality associated progression disease
recently hardware performance mobile devices extremely increased advanced mobile devices provide multi cores high clock speed addition mobile devices advantages mobility portability compared console many games simulation programs developed mobile environments physically based simulation one key issues deformable object modeling widely used represent realistic expression soft objects tetrahedrons game simulation however requires high computation power plausibly realistically represent physical behaviors interactions deformable objects paper implemented parallel cloth mass spring simulation using graphics processing unit gpu opencl multi threaded central processing unit cpu mobile device applied cpu gpu parallel computing technique spring force computation integration methods euler midpoint order runge kutta optimize computational burden dynamic simulation integration methods compute next step positions velocities node paper tested performance analysis spring force calculation integration method process using cpu multi threaded cpu gpu mobile device respectively experimental results concluded calculation using proposed multi threaded cpu gpu multi threaded cpu much faster using cpu
individuals many species regulate physiology morphology behavior response annual changes day length photoperiod mammals photoperiodic signal mediated change duration melatonin leading alterations gene expressions neuronal circuits hormonal secretion hippocampus one plastic structures adult brain hippocampal neuronal morphology displays photoperiod induced differences hippocampus important emotional cognitive behaviors photoperiod driven remodeling hippocampal neurons implicated seasonal differences affect including seasonal affective disorder sad humans neuronal architecture also affected day night cycle several brain areas hypothesized hippocampal neuronal morphology would display diurnal rhythm day length would influence rhythm present study examined diurnal seasonal differences hippocampal neuronal morphology well mrna expression neurotrophic factors brain derived neurotrophic factor bdnf tropomyosin receptor kinase trkb receptor bdnf vascular endothelial growth factor vegf circadian clock gene bmal hippocampus siberian hamsters diurnal rhythms total length dendrites number primary dendrites dendritic complexity distance furthest intersection cell body observed long day animals however diurnal rhythms number branch points mean length segments observed short day animals spine density dendrites displayed diurnal rhythmicity different peak times subregions long short days results indicate photoperiod affects daily morphological changes hippocampal neurons daily rhythm spine density suggesting possibility photoperiod induced adjustments hippocampal neuronal dynamics might underlie seasonal difference affective responses bmal mrna showed diurnal rhythm different expression levels long short days observed however strong effects day length bdnf trkb vegf gene expression suggesting genes involved photoperiodic effects hippocampal neurons
small scale fixed bed coal biomass gasifiers represent attractive option distributed combined heat power generation known gasification phenomena complex involving drying devolatilization pyrolysis heterogeneous homogenous reactions large number intermediate final products gasification processes also influenced reaction kinetics fluid dynamical effects temperature concentration gradients reason simulation models able predict gasifiers performance assumption thermodynamic equilibrium gasification process takes place known temperature reaction time lower reactants residence time consequence fixed bed gasifiers equilibrium models must consider drying devolatilization taking place lower temperature heat transfer zone solid feed heated syngas therefore moisture volatiles involved gasification reactions since released reaching reaction zone several models based steady state one dimensional representations developed reproduce gasification processes fixed bed reactors models found adequate provide information engineering design process optimization framework steady state simulation model developed department mechanical chemical materials engineering dimcm university cagliari using aspen plus computer code predicting performance small scale draft fixed bed coal gasifiers model used evaluate mass energy balance zone gasifier main characteristics syngas produced gasification process composition mass flow temperature heating value etc paper describes model presents main results parametric analysis shows gasification process influenced main operating parameters moreover results model compared experimental results draft gasifier fed lignite alaska mentioned gasifier part pilot gasification gas treatment plant built sotacarbo research centre sardinia italy comparison shows model well represents performance pilot scale unit elsevier ltd rights reserved
disuse induces rapid bone loss humans animals hypodynamia sedentarity recognized risk factor osteoporosis hypodynamia also decreases bone mass effects largely unknown animal models described hypodynamic chicken recognized suitable model bone loss effects quality fully explored used ten chickens bred large enclosure free group ten others confined small cages little space move around hypo group sacrificed days femurs evaluated microcomputed tomography microct nanoindentation sections thick analyzed fourier transform infrared microspectroscopy ftir see effects mineralization collagen quantitative backscattered electron imaging qbei image mineral bone matrix trabecular bone volume microarchitecture significantly altered hypo group ftir showed significant reduction mineral matrix ratio hypo group associated increase carbonate content increase crystallinity calculated area ratio subbands located indicating poor quality mineral collagen maturity calculated area ratio subbands located significantly reduced hypo group reduced biomechanical properties observed tissue level confined chicken represents new model study hypodynamia bone changes created surgical lesion traumatic method animals reduced bone mass present altered bone matrix quality less mineralized whose collagen contains less crosslinks control chicken
idiopathic pulmonary fibrosis ipf common disease group interstitial lung diseases occurs mainly middle aged elderly people past decade considerable changes approaches diagnosing treating ipf paper presents update epidemiology ipf results new studies pathogenesis main approaches diagnosing disease addition new evidence therapy ipf
review aims summarize information genetic etiology attention deficit disorder hyperactivity adhd particular reference contributions research group also discuss genetic comorbidity estimated genome wide single nucleotide polymorphisms snp adhd major psychiatric disorders schizophrenia major depressive disorder mdd bipolar disorder autism spectrum disorders asd high genetic comorbidity found moderate comorbidity mdd mdd mdd adhd respectively low comorbidity asd furthermore show evidence concerning genetic determination psychiatric diseases significantly lower estimated genome wide snp rather using traditional quantitative genetic methodology adhd mdd asd evolutionary perspective suggest behavioral traits hyperactivity inattention impulsivity play role adhd perhaps also hereditary traits part major psychiatric disorders could high adaptive value early stages evolution homo sapiens however became progressively less adaptive definitively disadvantageous extreme involved frequently diagnosed major psychiatric disorders
exponential smoothing models represent important prediction tool business macroeconomics paper provides analytical forecasting properties random coefficient exponential smoothing model multiple source error framework random coefficient state space representation allows switching simple exponential smoothing local linear trend therefore enables controlling flexible manner random changing dynamic behavior time series paper establishes algebraic mapping state space parameters implied reduced form arima parameters addition shows parametric mapping allows overcoming difficulties likely emerge estimating directly random coefficient state space model finally presents empirical application comparing forecast accuracy suggested model vis vis benchmark models arima exponential smoothing class using time series relative wholesalers inventories usa sample results show reduced form random coefficient exponential smoothing model tends superior competitors elsevier rights reserved
work demonstrate quad edge mesh data structure efficiently used construct large shapes developed system unfold polygonal mesh based quad edge structure using system shape constructed using laser cut developable panels approach particularly suitable construct complicated sculptural architectural shapes anisotropic materials bent one direction elsevier ltd rights reserved
ambient intelligence ami technologies potential create intelligent environments new generation assistive services enhanced ubiquitous robots environments ability anticipatory responsive intelligent providers assistive services anytime anywhere services assist frail persons effectively daily tasks one main challenging research problems assistive robotics endow ubiquitous robots ability pro actively taking tasks help humans performing complex activities participating humans normal societies organizations paper propose collective intelligence framework based narrative reasoning natural language processing proposed approach propose hybrid model bridges together narrative knowledge representation language nkrl natural language processing field harms humans software agents robots machines sensors model multi agent systems engineering field model able drive dialogues humans robots smart devices understand complex situation iii trigger reactive actions ubiquitous environment according given contexts two scenarios dedicated assistance frail person smart home equipped companion robot smart objects implemented discussed validation purposes proposed framework elsevier rights reserved
analyses sexual orientation earnings find gay men face wage gap whereas lesbian women earn higher wages similar heterosexual women however analyses rarely consider bisexual men women unique group separate sexual minorities argue binary views sexual orientationtreating sexual minorities homogenous non heterosexual grouphave obscured understandings impact sexual orientation labor market outcomes specifically predict unequal outcomes gay men lesbian women partly due influence family arrangements effects earnings contrast argue bisexual men women disadvantaged labor market due particularly disadvantaging stereotypes perceptions choice sexual orientation prejudicial treatment using data general social survey national longitudinal study adolescent adult health show family arrangements explain observed earnings differentials gay men lesbian women bisexual men women contrast face wage penalties explained human capital differences occupational characteristics perceptions prejudicial treatment partially explain observed wage gaps
application geosynthetics hydrotechnical engineering requires appropriate selection respect soil properties operational conditions structures paper presents case slope failure deep drainage channel caused geotextile clogging phenomenon resulting selecting inappropriate material respect soil parameters due rapid changes water level channel occur operation required protect slope periodically occurring seepage forces slope reinforcement performed placing draining gravel layer geotextile cohesive soil top openwork concrete plates laid despite reinforcement intense rainfall even channel filled long section slope slid destroyed ecological reinforcement channel bottom paper phenomenon explained analysis slope equilibrium conditions along laboratory tests water permeability clogging process applied geotextile
current study investigates two types cultural diversity approaches school namely fostering equality promoting cultural pluralism adopting mixed methods design study assesses teachers students self reported perceptions descriptive norms evaluates school practices artefacts physical virtual environment secondary schools south west germany results showed schools investigation teachers students perceived descriptive norms fostering mostly equality wide variety practices artefacts found revealing third distinct cultural approach leaning towards endorsing majority culture different practices artefacts linked emphasis equality cultural pluralism endorsing majority culture implications educational policy well applied diversity research discussed elsevier ltd rights reserved
hydropower units subject several forces couples certain conditions cause noise vibration interaction problems electric network even equipment failure objective develop numerical models hydroelectric generator taking consideration shaft interaction order study behavior generator analytical method implemented order study interaction oscillation mechanical couple network influence electromagnetic couple finite element model developed order study impact eccentricity generator origin unbalanced magnetic pulls depending degree eccentricity resulting electromagnetic force significant finally aim work contribute study dynamic behavior shaft hydropower units
previous brain imaging studies demonstrated seasonal difference serotonin transporter sert binding human brain however results somewhat contradictory conducted test retest study single photon emission computed tomography spect adam ligand healthy subjects ten subjects studied within month whereas randomly assigned studied period year primary measure specific uptake ratio sur regions interest included midbrain thalamus putamen caudate intra class correlation coefficient icc across different brain regions month whereas icc year period month variability ranged across different brain regions year variability ranged kruskal wallis test revealed significant difference variability across months wilcoxon signed ranks test showed sur test retest scans borderline significance curve fitting using degree polynomial model revealed significant circadian correlation variability interval test retest measurements findings demonstrate test retest reproducibility adam different time periods suggest circadian variation sert levels human brain might exist elsevier ireland ltd rights reserved
autism spectrum disorder asd complex neurodevelopmental disorder mainly showed atypical social interaction communication restricted repetitive patterns behavior interests activities clinic diagnosis asd mostly based psychological evaluation clinical observation medical history behavioral indexes could avoid defects subjectivity reporter dependency therefore researchers devoted seek relatively stable biomarkers asd supplementary diagnostic evidence goal present study generate relatively stable predictive model based anatomical brain features using machine learning technique forty six asd children thirty nine development delay children aged months evolved result predictive model generated regional average cortical thickness regions top highest importance random forest classifier showed best diagnostic performance random forest proved optimal approach neuroimaging data mining small size set thickness based classification outperformed volume based classification surface area based classification asd brain regions selected models might attract attention idea considering biomarkers supplementary evidence asd diagnosis worth exploring autism res international society autism research wiley periodicals inc autism res international society autism research wiley periodicals inc
netherlands unique perinatal healthcare system high rate home births early discharge delivery hospital although demonstrated pulse oximetry screening critical congenital heart disease feasible netherlands unknown whether parents find screening acceptable performed home birth setting assessed acceptability screening mothers screening home setting questionnaire sent electronically mothers gave birth postnatal care supervision community midwife participating pulse oximetry leiden screening pols study feasibility study screening dutch care system performed leiden region netherlands questionnaire included questions based satisfaction general feelings perceptions screening total mothers completed questionnaire overall mothers happy performance test thought baby comfortable screening feel stressed screening performed mothers would recommend test others considered test important babies conclusion mothers newborns participating study found screening acceptable performed home
paper discuss philosophical psychopathological background domain persons examination anomalous world experiences eawe eawe interview aims describe manifold phenomena schizophrenic lifeworld concrete distinctive features thus complementing abstract symptom focused approach domain persons focuses specifically subjectively experienced interpersonal disturbances may especially common schizophrenia aim domain rest eawe provide clinicians researchers systematic orientation toward knowledge patients experiences experiential universe schizophrenia clarified terms particular feel meaning value patient help provide context eawe domain persons propose definition intersubjectivity dissociality former ability understand persons basis capacity experience people social situations meaningful relies perceptive intuitive well cognitive computational resources dissociality addresses core psychopathological nucleus characterizing quality abnormal persons schizophrenia covers several dimensions including disturbances perceptive intuitive cognitive computational capacities typical perceptive intuitive abnormality hypoattunement lack interpersonal resonance difficulties grasping immediately understanding others mental states characteristic cognitive computational anomaly social hyperreflexivity especially algorithmic conception sociality observational ethological attitude aimed develop explicit often rule based personal method participating social transactions anomalous interpersonal experiences emotional behavioral responses others also discussed relation core dissociality karger basel
cardiac transplantation associated high risk fracture african americans aas believed lower risk osteoporosis caucasians clear whether also protected osteoporosis resulting use glucocorticoids organ transplantation examined possible ethnic differences cardiac transplant recipients aas cross sectional analysis addition bone mineral density vertebral fracture assessment also compared biochemical variables trabecular bone score total body dual energy ray absorptiometry disability overall fracture rates low groups total subjects fractures vertebral fracture assessment history fracture scores similar groups scores lower difference reaching statistical significance controlling important covariates trabecular bone score also lower aas caucasians even adjusting age tissue thickness aas generally thought protected osteoporosis study instead suggests aas may higher risk bone deterioration cardiac transplantation may need managed aggressively suggested current guidelines
data dependencies useful tool design relational databases particular functional multivalued dependencies used obtain relation schemes satisfy normal form property considered good enough applications known class sets functional dependencies learnable exact model learning queries also subclass multivalued dependencies class consequent restricted multivalued dependencies shown learnable model present algorithm learns generalization classes also show algorithm learns non trivial subclass quasi horn formulas closely related classes mentioned
modeling individual fish habitat selection highly variable environments hydropeaking rivers required guiding efficient management decisions analyzed fish microhabitat selection heterogeneous hydraulic thermal conditions modeled two dimensions reach large hydropeaking rhone river locally warmed cooling system nuclear power plant used modern fixed acoustic telemetry techniques survey fish individuals five barbels six catfishes seven chubs signaling position every three month period fish habitat selection depended combinations current microhabitat hydraulics velocity depth past microhabitat hydraulics dewatering risk maximum velocities past days lesser extent substrate temperature mixed effects habitat selection models indicated individual effects often stronger specific effects rhone fish individuals appear memorize spatial temporal environmental changes adopt least constraining habitat selection avoiding fast flowing midstream habitats fish generally live along banks areas dewatering risk high discharge decreases however select higher velocities avoid dewatering areas fast flowing midstream habitats although consistent available knowledge static fish habitat selection quantitative results demonstrate temporal variations habitat selection depending individual behavior environmental history generality could tested using comparative experiments different environmental configurations elsevier rights reserved
platform electrochemical transduction suitable miniaturised point care diagnostic solutions intuitive optical read designed electrolytic current electrochemical cell transduced glow light emitting diode performance optimised several variants transducing circuitry tested circuit comprising field effect transistor fet exhibited sought abilities absolute simplicity high tuneable sensitivity transducing device limit detection signal readable naked eye without additional instrumentation low direct assay whole transducing system employing fet consisted shelf components price reached sic even small scale experimental production system rather suitable semiquantitative yes applications due steep response curve alternative circuitry widening linear range also probed finally rather higher initial voltage required electrochemical cell fet based transducer lead design simplified variable circuit employing operational amplifier elsevier ltd rights reserved
research suggests higher levels authoritarian parenting exist african american families european american families authoritarian attitudes may associated positive outcomes families families however less known authoritarian attitudes children development within families within group study african american mothers year old children examined associations maternal authoritarian attitudes observed maternal limit setting strategies children self regulation limit setting interaction findings indicate families may hold authoritarian attitudes families direction effect authoritarian attitudes children outcomes appears ethnic groups sample examining authoritarian attitudes relative mothers less lower authoritarian attitudes associated authoritative limit setting behavior firm limits within context overall warmth responsiveness better children self regulation
weight suppression predicts onset maintenance bulimic syndromes despite finding study examined psychological mechanisms contributing associations using longitudinal design given societal pressures thin actual history higher weight possible greater weight suppression contributes increased fear gaining weight preoccupation thin increase vulnerability eating disorders present study investigated whether greater drive thinness mediates associations weight suppression bulimic symptoms long term follow participants women men completed self report surveys college years later higher weight suppression baseline predicted higher bulimic symptoms year follow accounting demographic variables baseline bulimic symptoms body mass index drive thinness increased drive thinness year follow mediated effect findings highlight long lasting effect weight suppression bulimic symptoms suggest preoccupation thinness may help maintain association future studies would benefit incorporating hypothesized consequences weight suppression including biological factors risk models general scientific summary weight suppression difference individual highest past current weight risk factor maintenance bulimic syndromes current study supports weight suppression contributes increased preoccupation thin serves key link weight suppression bulimic symptoms
teens tend bed later get less sleep report daytime sleepiness medical research emphasizes biological determinants teens disrupted sleep timing puberty resultant drops melatonin rarely inadequately considering youths social ties determinant sleep behaviors sociologists recognize social ties affect health behaviors generally neglected sleep especially among teens drawing sample teens study early child care youth development study controls developmental social relational factors predict changes youths sleep patterns years age general social relational factors outperform developmental factors determining youths sleep patterns particularly pointing importance parental peer school ties promoting healthy sleep behaviors implications findings research briefly discussed
tremendous interest enzymes biocatalysts led extensive work enzyme engineering well associated methodology development new framework computer aided directed evolution enzymes cadee presented allows drastic reduction time necessary prepare analyze silico semi automated directed evolution enzymes pedagogical example application cadee real biological system also presented order illustrate cadee workflow
paper presents new enhanced stego block chaining esbc technique data hiding address bandwidth transmission time issues simple stego block chaining sbc simple sbc data hiding method security hidden information increased increasing number stages addition stage decreases hiding capacity increases size data needed transmit secret message thus results increase required bandwidth transmission time proposed esbc technique addresses bandwidth transmission time issues simple sbc method output esbc high quality stego image peak signal noise ratio provides additional security simple sbc reduces requirements bandwidth transmission time one half simple sbc thus solves hiding capacity issues sbc low bandwidth channels copyright john wiley sons ltd
objective aim study investigate prevalence risk malnutrition rom orthopedic traumatology patient cohort broad range ages addition classical indicators risk assessment low body mass index weight loss comorbidity study aimed analyze effects lifestyle factors eating pattern smoking physical activity rom methods prospective cohort study included patients level trauma center germany rom assessed nutritional risk screening nrs elderly additionally mini nutritional assessment mna age dependent risk factors identified univariate statistical analysis used multivariate logistic regression models results prevalence patients rom nrs three age categories loss appetite weight loss number comorbidities drugs gastrointestinal symptoms significantly increased rom univariate statistical analysis patients ages several disease lifestyle related factors living home less frequent consumption vegetables whole meal bread low physical activity smoking associated rom multivariate logistic regression model total study population identified weight loss odds ratio confidence interval loss appetite age specific low bmi number drugs taken age days per week vegetable consumption risk factors conclusion malnutrition trauma orthopedic patients problem related age lifestyle related factors also contribute significantly malnutrition geriatric patients elsevier inc rights reserved
monte carlo simulations well established methodology numerically assess effect variations mechanical aerodynamic parameters aeroelastic stability suspended bridge research paper use statistical approach present design methodology assessment long span aeroelastic behavior considers flutter velocity unique safety index common practice also trend total damping function wind velocity specifically several significant service conditions considered indeed wind velocities service conditions events probability much higher flutter condition cases reliability analysis represents added value design process therefore statistical analysis total damping service conditions suggested useful tool judge performance structure especially structures wind structure interaction represents capital aspect overall design happens long span bridges given probability distribution input parameters monte carlo simulations allows one statistically investigate aeroelastic stability structure terms range variation total damping flutter velocity eigenvalue analysis also possible state probability matching design technical specification probability certain prescribed variation band mathematical statistical background design methodology presented case study analyzed reference messina straits bridge test case chosen stress methodology challenging design extreme structural aerodynamic solutions implemented reach main span length performances structure deeply bounded reliability aeroelastic design elsevier ltd rights reserved
background study aim every sport fighting least two athletes essence struggle select one winner apart possible many sports tie lack decision fight physical effort always risk injury even death one even athletes sport fighting also need overcome weaknesses order finally realize passions combat sports disciplines elevated degree injury rate aim study verify hypothesis injuries judo wrestling judo involves injuries upper extremities comparison wrestling injuries lower extremities frequent sports injuries occur often competitions materials methods study involved male female competitors including judo wrestling information sport injuries gathered means specially developed questions contained questionnaire obtained results analysed results main causes injuries judo indicated respondents include poor warm incomplete healing previous injuries direct fight hand wrestling injuries caused direct fight poor warm incomplete healing previous injury vast majority competitors responded continue participate training competition despite pain answers provided competitors reveal respondents suffered least one injury sporting career following number athletes study group judo wrestling suffered injury judo wrestling frequent injures included ones lower extremities judo wrestling respondents suffered injury sporting career conclusions hypothesis turned large extent false proportion injuries noted wrestling especially within upper extremity head however issue turned real lower extremity prone injuries among judo athletes followed upper extremity head relationship conspicuous among wrestling athletes general lower traumatism among judo athletes exception lower extremity explained fact judo basic element training safe fall ukemi waza
perceptions judgments social workers interview child family especially significant factors child abuse assessment process current study describes compares child protection workers assessment processes korea usa use case vignettes depth interview responses social workers two countries compared discussed areas risk assessment perception main problems tolerance corporal punishment judgments appropriateness interventions revealing korean social workers determined abuse based child abuse definition army fap social workers determined abuse based definition affected legal standards cultural differences korean social workers likely remove child home even mild cases fap social workers would recommend child removal home last option social workers participated survey play vital role safety children child protective services countries benefit sharing information improve child protection services delivered social workers professional judgment leads objective consistent outcomes less likely compromise child safety decision making process
evaluating daily life quality important ambient intelligence applications targeted health status monitoring consider fact people approximately spend one third lives sleeping need monitor sleep quality well activities daily living order able provide seamless health monitoring system paper seamless activity recognition system makes use multi modal wireless sensor networks wsns mobile phones proposed proposed system used collect life log sleep behavior data actual users lights information important factors affecting sleep quality person extracted
cobalt promising soft metallic magnetic material used important applications field absorbing stealth technology especially absorbing centimeter waves however frequently presents weak dielectric property instability aggregation crystallographic form method enhancing electromagnetic property metal via phase controlled synthesis nanostructures grown graphene networks developed hexagonal close packed cobalt alpha nanocrystals face centered cubic cobalt beta nanospheres uniform size high dispersion successfully assembled nanosheets via facile one step solution phase strategy different reaction conditions exfoliated graphite oxide graphene oxide nanosheets reduced along formation nanocrystals synthesized nanocomposites showed excellent microwave absorbability comparison corresponding nanocrystals especially nanocomposites alpha nanocrystals reflection loss ghz probably special electrical properties cross linked nanosheets perfect electromagnetic match microstructure well small particle size nanocrystals approach convenient effective magnetic metal alloy materials also prepared via route versatility
paper presents robust color image watermarking algorithm based fuzzy least squares support vector machine fls svm bessel form bkf distribution recently developed geometric correction algorithm firstly compute quaternion discrete fourier transform qdft maximum central region original color image watermark embedded magnitudes low frequency information qdft watermark decoding process synchronous correction based fls svm model used training fls svm model firstly perform quaternion wavelet transform qwt grayscale images correspond color training images use bkf distribution fit empirical histogram coefficients qwt finally use shape parameters scale parameters bkf distribution construct image feature vector experimental results show proposed algorithm invisible also outstanding robustness common image processing attacks geometric attacks
development bioinspired devices energy efficient computing requires numerical models reproduce global electrical behavior neurons present herein stochastic model based monte carlo technique reproduce steady state action potential neurons terms probabilities different ions cross cell membrane gating channels sodium potassium cations leakage channels taken account following hodgkin huxley equations first stage expand model include time dependent ion concentrations intra extracellular space related nernst potentials existence ion pumps equilibrate steady state currents model allows monitoring random passage ions across biological membrane thus includes influence ion shot noise small membrane areas results evidence considered alone shot noise discernible effect spiking wide range excitation currents leading onset spikes also inhibiting appearance
examined whether apolipoprotein apoe status interacts vascular risk factors vrfs predict progression white matter hyperintensities wmhs brain mri scans specific period life older age risk dementia increases age years baseline vrfs assessed via self reported history diabetes hypertension smoking hypercholesterolemia via objective measures blood hbac body mass index diastolic systolic blood pressure blood high density lipoprotein total cholesterol hdl ratio apoe allele coded either present absent wmh progression measured mri years older adults year birth cohort apoe carriers either self reported diagnosis diabetes beta higher glycated hemoglobin levels beta exhibited greater wmh progression former survived correction multiple testing apoe vrf interactions nonsignificant beta interaction results suggest carrying apoe risk allele increases risk greater age related wmh progression early part eighth decade life combined poorer glycemic control interaction effect robust occurring vrfs suggesting possible target mitigating brain cognitive aging age authors published elsevier inc open access article license
sleep circadian rhythms intrinsically linked several sleep traits including sleep timing duration influenced sleep homeostasis circadian phase genetic variation several circadian genes associated diurnal preference preference timing sleep although limited research whether associated sleep measurements investigated whether genetic variations associated diurnal preference morningness eveningness questionnaire various sleep measures including global pittsburgh sleep quality index score sleep duration sleep latency sleep quality genotyped polymorphisms genes circadian expression participants sample british longitudinal population sample young adults conducted linear regressions using dominant additive recessive models inheritance test associations polymorphisms sleep measures found significant association diurnal preference polymorphism period homologue per recessive model novel nominally significant association diurnal preference polymorphism aryl hydrocarbon receptor nuclear translocator like arntl additive model found polymorphism guanine nucleotide binding protein beta beta associated significantly global sleep quality recessive model rare polymorphism period homologue per associated significantly sleep duration quality recessive model findings suggest genes circadian expression may play role regulating circadian clock sleep homeostasis highlight importance studies aimed dissecting specific roles circadian genes play two interrelated unique behaviours
background unwanted pregnancies major public health problem developing developed nations generally results ineffective use contraceptives end induced abortions emergency contraception sometimes called morning postcoital second chance pills used prevent pregnancy unprotected sex attention focused potential emergency contraception reduce number unwanted pregnancies thus abortion rate objectives compare awareness emergency contraceptive pills conventional contraceptive methods among mothers attending mch clinic bapuji hospital davangere study socio demographic profile group methods pre tested semi structured questionnaire used know awareness emergency contraceptive pills versus conventional contraceptive methods among mothers attending mch clinic bapuji hospital davangere october december data entered excel sheet analysed using spss software version data described proportions categorical data using chi square test results total mothers included study duration months approximately respondents age group yrs urban background hindus joint family approximately belonged socioeconomic class iii literate housewives knowledge emergency contraception less compared conventional methods practiced emergency contraception poor compared conventional methods aware female sterilization common known temporary method contraception followed ocp common method used couples condom followed practiced contraception birth child undergone medical abortion previously aware pregnancy terminated medical means correctly identified recommended hrs time limit use emergency contraception none knowledge existence iucd ocp emergency contraception source information emergency contraception maximum television followed paramedics doctors conclusions study reveals good knowledge family planning respondents aware least one method contraception practice using contraception poor
online social networking sites facebook provided new platform individuals produce reproduce gender social interactions new mothers particular may use facebook practice behaviors align mothering identity meet broader societal expectations words motherhood given facebook use may undermine well important understand individual differences underlying new mothers experiences facebook stressful first months parenthood using survey data sample new mothers facebook accounts residing midwest addressed two key questions individual differences new mothers psychological characteristics associated use experiences facebook new mothers psychological characteristics associated greater risk depressive symptoms via use experiences facebook regression analyses revealed mothers concerned external validation identities mothers believed society holds excessively high standards parenting engaged frequent facebook activity also reported stronger emotional reactions facebook commentary moreover mothers concerned external validation likely featured child facebook profile picture mediation analyses indicated mothers prone seeking external validation mothering identity perfectionistic parenting experienced increases depressive symptoms indirectly via greater facebook activity
sharing rows columns networked resistive sensor arrays simplified interconnect complexity suffered crosstalk problem among elements crosstalk mainly affected multiplexers resistor adjacent column elements adjacent row elements array size first designed improved isolated drive feedback circuit iidfc using one operational amplifier reduce crosstalk caused adjacent column elements networked resistive sensor array mathematical equivalent resistance expression element tested ebt circuit analytically derived iidfc equivalent resistance expression ebt evaluated simulations simulation results show iidfc greatly reduce crosstalk error caused adjacent column elements networked resistive sensor array row column fashion resistance expression ebt used general formula evaluate performance iidfc
unmanned aerial vehicles prime targets morphing implementation must adapt large changes flight conditions associated locally varying wind large changes mass associated payload delivery spanwise morphing trailing edge concept locally varies trailing edge camber wing control surface functioning modular replacement conventional ailerons without altering spar box utilizing alternating active sections macro fiber composites mfcs driving internal compliant mechanisms inactive sections elastomeric honeycombs smte concept eliminates geometric discontinuities associated shape change increasing aerodynamic performance previous work investigated representative section smte concept investigated effect various skin designs actuation authority current work experimentally evaluates aerodynamic gains smte concept representative finite wing compared conventional articulated wing comparative performance wings evaluated measuring drag penalty associated achieving design lift coefficient design angle attack reduce experimental complexity optimal control configurations predicted lifting line theory experimentally measured control derivatives evaluated range design flight conditions metric captures comparative capability concepts adapt morph changes flight conditions even simplistic model smte concept shown reduce drag penalty due adaptation design conditions justifying increase mass complexity motivating concepts capable larger displacement ranges higher fidelity modelling condition sensing control
pulmonary surfactant fulfils diverse functions lung air liquid interface air breathing vertebrates neurohormonal regulation surfactant synthesis secretion highly conserved among non mammalian amniotes although pattern surfactant lipid maturation similar among species onset completion differ dramatically differences apparently determined phylogeny may relate timing development relative hypoxia embryo develops related birthing strategy proposed hypoxia evolutionary drive differential surfactant development among species mammalian non mammalian models hypoxia induces fetal growth restriction depending timing insult may associated acceleration deceleration surfactant development hypoxic effect may mediated via hormonal growth factors glucocorticoids vegf however multifactorial nature mammalian growth restriction models complicates mechanistic interpretations hence less complex oviparous animal models required hypoxia isolated maternal influences elsevier rights reserved
synergetic control theory introduced hydraulic generator excitation system hges hydraulic generator governing system hgrs paper synergetic excitation controller sec synergetic governing controller sgc hgu designed order enhance terminal voltage control mechanical power tracking performances simultaneously integrated synergetic controller isc also proposed isc implements synergetic control terminal voltage rotor speed mechanical input power guide vane opening namely isc considering excitation system governing system hydraulic generator unit hgu provide control function instead sec sgc addition control rules aforementioned three controllers deduced nonlinear mathematical analytic model hydroelectric generator unit end paper comparative case studies proposed sgc sec isc classic pid controller presented results show proposed isc improves nonlinear hgu system performance accurate precision shorter settling time different operating conditions
polychlorinated biphenyls pcbs associated adverse human reproductive fetal developmental measures outcomes endocrine disrupting effects however biological mechanisms adverse effects pcb exposure humans currently well established study aimed identify biological pathways potential biomarkers pcb exposure maternal umbilical cord serum using hydrophilic interaction chromatography tandem mass spectrometry hilic metabolomics platform median concentration total pcbs maternal cord serum wet respectively pcb levels maternal fetal serum chiba study mother children health mach cohort comparable earlier cohort studies conducted japan usa european countries used random forest model metabolome profile predict exposure levels pcb first quartile fourth quartile pregnant women fetuses prediction model classification versus area curve auc pregnant women fetuses citraconic add level maternal serum ethanolamine hydroxybenzoate purine levels cord serum auc values candidate biomarkers metabolite included composited models related glutathione amino acid metabolism maternal serum amino acid metabolism ubiquinone terpenoid quinone biosynthesis cord serum fdr indicating disruption metabolic pathways pcb exposure pregnant women fetuses results showed metabolome analysis might useful explore potential biomarkers related biological pathways pcb exposure thus detailed studies needed verify sensitivity biomarkers clarify biochemical changes resulting pcb exposure authors published elsevier ltd open access article license http creativecommons org licenses
patients bipolar disorder high risk developing cardiovascular diseases cvds aging process however investigations lacking regarding risk factors cvds specific patients aim study examine relationship cvds traditional risk factors association characteristics older age totally recruited patients dsm least one psychiatric admission cardiologist confirmed cvd diagnosis icd code mean age years case subject matched one patient without cvds based age sex date recent psychiatric admission years clinical data obtained retrospectively reviewing medical record multiple logistic regression model showed traditional risk factor diabetes mellitus also non traditional one associated first episode mania significantly increased risk cvds given limitation cross sectional study longitudinal investigations needed elucidate contributions traditional risk factors characteristics cvd risk patients
prevalence metabolic syndrome increasing african populations particularly high black south african women women united kingdom united states america population group also known highest prevalence obesity sub saharan african region consequently high risk non communicable diseases article discuss factors abdominal subcutaneous fat visceral fat lean mass adiponectin leptin vitamin smoking menopausal status investigated possible association metabolic syndrome african women discuss recommendations management syndrome particular infrastructural development hiv aids clinics south africa provides ideal integrated platform cater treatment needs patients multiple chronic morbidities
method estimation structural defects density whole wafer area parametric wafer map creation considered technique allows fast accurate estimation defects density wafer area wafer batch input offset voltage operational amplifier amp calculated function structural defects density example corresponding parametric map shown opportunity localize origin structural defects technological route discussed
current geophysical techniques visualizing seismic activity employ image reconstruction methods rely centralized approach processing raw data captured seismic sensors data either gathered manually relayed expensive broadband stations processed base station approach time consuming weeks months hazardous task involves manual data gathering extreme conditions also raw seismic samples typically range bit sampled transferring high fidelity sample large number sensors centralized station results bottleneck due bandwidth limitations avoid issues new distributed method required processes raw seismic samples inside node obtains high resolution seismic tomography real time paper present component averaged distributed multi resolution evolving tomography algorithm processing data inverting volcano tomography network avoiding centralized computation costly data collection algorithm first evaluated correctness using synthetic model core emulator later proposed algorithm runs using real data obtained helens usa results validate distributed algorithm able obtain satisfactory image similar centralized computation constraints network resources distributing computational burden sensor nodes elsevier inc rights reserved
zebrafish danio rerio important vertebrate model organism biomedical research especially suitable morphological screening due transparent body early development deep learning emerged dominant paradigm data analysis found number applications computer vision image analysis demonstrate potential deep learning approach accurate high throughput classification whole body zebrafish deformations multifish microwell plates deep learning uses raw image data input without need expert knowledge feature design optimization segmentation parameters trained deep learning classifier images data augmentation achieved classification accuracy unseen test data set comparable previous state art based user specified segmentation deformation metrics ablation studies digitally removing whole fish parts fish images revealed classifier learned discriminative features image foreground observed deformations head region rather visually apparent bent tail important good classification performance
high mobility group box hmgb critical pro inflammatory cytokine contributes pathogenesis various human diseases flz squamosamide derivative demonstrated neuroprotective effects parkinson disease models shows strong anti inflammatory activity precise mechanism remains unclear investigated anti inflammatory mechanism flz hmgb mediated inflammatory responses effects flz hmgb release microglial cells induced lipopolysaccharide first explored western blot assay elisa immunoprecipition used study flz effect interaction hmgb receptor tlr finally employed hmgb simulate pro inflammatory responses studied inhibitory effects flz bioactivity flz significant inhibitory effect hmgb release exerts inhibitory effect binding hmgb tlr recognition hmgb tlr kappa signaling pathway activated flz could efficaciously alleviate hmgb induced inflammatory responses via suppression tlr myd kappa signaling pathway flz could inhibit hmgb release well hmgb induced inflammatory responses hmgb might one flz anti inflammatory targets interfering inflammatory mediator may benefit effects neurodegenerative disorders parkinson disease
human social perception communication interaction require efficient analysis representation person related information faces voices convey large variety socially relevant information including person identity emotions gender age attractiveness ethnic group focus attention however perceptual mechanisms processing complex social stimuli recently become focus systematic research development arguably facilitated availability sophisticated stimulus manipulation techniques image video voice morphing caricaturing averaging allowing researchers create completely naturalistic person stimuli perceptual social cues nevertheless precise experimental control availability methods cognitive social neurosciences review current status field person perception discuss selected examples highly active areas research show person perception currently developed central topic within psychological research evidence emerging suggest perceptual social cues faces voices spontaneously used promote first impressions people also impressions show degree validity suggesting faces voices seen windows person behind accordingly argue progress fields social cognition deal real virtual agents theory mind research social categorization human decision making enhanced considering strongly influences perceptual facial vocal person information
external overvoltages constitute typical cause faults damages interruptions electrical networks high voltage transmission lines order protect lines equipment lightning overhead ground wires combination surge arresters installed improving lightning performance system reducing annual failure rate achievement low values earth resistance essential requirement since good grounding system reduces considerably corresponding insulation breakdowns however behaviour surge arresters relation grounding resistance different depends position lightning hit current work devoted sensitivity analysis failure probability surge arresters relation grounding resistance investigating concurrently effect arresters installation interval energy absorption capability
usually students face different difficulties learning computer programming leads many drop computing major continue fear programming assignments subsequent courses main reason difficulties inappropriate method used students study subject paper describe experience using journal train students self regulated learning skills studying computer programming although using tool many challenges proves effectiveness improving students self regulated learning skills consequently enhances students performance introductory computer programing course
kinetics trap generation negativebias temperature instability nbti stress pmosfets governed double interface reaction diffusion model incorporated first time commercial technology computer aided design tcad software used simulating degradation various device architectures calibrated tcad framework shown successfully explain measured impact interface trap generation delta bulk silicon finfets wide range stress bias temperature impact device design nbti degradation explored comparing simulated trap generation kinetics bulk finfet silicon insulator finfet gate around nanowire fet devices different geometries simulated predictions agree well experimental observations reported literature proposed tcad framework would enable performance reliability optimization device design advanced technology nodes
background systemic lupus erythematosus sle patients spain associated intestinal dysbiosis study explores whether alteration gut microbiome sle patients china consistent intestinal dysbiosis sle patients spain results depletion firmicutes enrichment bacteroidetes sle patients china consistent sle patients spain furthermore found nine genera gut microbiota sle related microorganisms chinese subjects genera rhodococcus eggerthella klebsiella prevotella eubacterium flavonifractor incertae sedis significantly enriched genera dialister pseudobutyrivibrio significantly depleted sle patients receiver operating characteristic analysis indicated nine genera potential distinguish sle patients healthy controls conclusions comparing dysbiosis gut microbiome among sle patients china spain may indicate gut microbiome profiles sle patients influenced disease ethnicity
background effects sodium glucose transporter type inhibitors home blood pressure examined type diabetes nephropathy methods patients diabetic nephropathy screened medical records hospitals among patients measured home blood pressure started take sodium glucose transporter type inhibitors selected clinical parameters including estimated glomerular filtration rate albuminuria home blood pressure months analysed results sodium glucose transporter type inhibitors luseogliflozin day canagliflozin day reduced body weight hbac albuminuria estimated glomerular filtration rate office blood pressure although sodium glucose transporter type inhibitors alter morning blood pressure reduced evening systolic blood pressure regression analyses revealed decreases evening blood pressure predicted decrements albuminuria conclusion present data suggest sodium glucose transporter type inhibitors suppress sodium overload daytime reduce evening blood pressure albuminuria
background debate remains whether high tibial osteotomy hto unicompartmental knee arthroplasty uka beneficial treatment unicompartmental knee osteoarthritis purpose study compare functional results knee scores activity levels complications two procedures methods performed systematic review published literature august january fifteen papers reporting three prospective randomized trials subjected meta analysis results significant difference two groups noted respect free walking velocity knee score deterioration contralateral patellofemoral knee revision rate total knee arthroplasty however uka produced better outcomes compared hto terms functional results pain assessment complications although patients underwent hto tended slightly better range motion conclusions valgus hto provides better physical activity younger patients whereas uka suitable older patients due shorter rehabilitation time faster functional recovery although uka patients tended improved overall long term outcomes may due accurate indications patient selection treatment options yielded pleasing results therefore unable conclude either method superior
additively manufactured metal components often exhibit fine dendritic microstructures elemental segregation due initial rapid solidification subsequent melting cooling build process without homogenization would adversely affect materials performance letter report situ observation homogenization kinetics nickel based superalloy using synchrotron small angle ray scattering identified kinetic time scale good agreement thermodynamic diffusion simulation predictions using microstructural dimensions acquired situ scanning electron microscopy findings could serve recipe predicting observing validating homogenization treatments materials acta materialia inc published elsevier ltd rights reserved
work results obtained virtualisation manufacturing processes engineering practices malaga university arc analyzed educative innovation tool allows increase efficiency students learning available previously means computer different practise classes later results show improvement obtained preliminary realization virtual way relation make attended practise present laboratory
tau well established microtubule associated protein neurons however pathological conditions aberrant assembly tau insoluble aggregates accompanied synaptic dysfunction neural cell death range neurodegenerative disorders collectively referred tauopathies recent advances understanding multiple functions different locations tau inside outside neurons revealed novel insights importance diverse range molecular pathways including cell signalling synaptic plasticity regulation genomic stability present review describes physiological pathophysiological properties tau relate distribution functions neurons highlight post translational modifications tau pivotal defining modulating tau localisation roles health disease include discussion pathologically relevant changes tau including mutation aggregation aspects impinge propensity tau propagate potentially drive neuronal loss diseased brain finally describe cascade pathological events may driven tau dysfunction including impaired axonal transport alterations synapse mitochondrial function activation unfolded protein response defective protein degradation important fully understand range neuronal functions attributed tau since provide vital information involvement development pathogenesis disease knowledge enable determination critical molecular pathways targeted potential therapeutic agents developed treatment tauopathies
background reproductive coercion impacts many women reproductive age objectives sought explore reproductive coercion including pregnancy coercion birth control sabotage impacts women primary care population methods administered survey women accessing care family medicine clinic bronx reproductive coercion defined positive response least one five questions adapted previous studies assessed association reproductive demographic characteristics lifetime history reproductive coercion results least one form reproductive coercion reported respondents current lack personal safety history transactional sex money place stay significantly associated experienced reproductive coercion conclusions reproductive coercion common among women reproductive age urban family medicine clinic underserved community associated forms control violence clinicians advised discuss birth control sabotage pregnancy coercion patients
background borderline personality disorder bpd avoidant personality disorder avpd characterized hyper reactivity negatively perceived interpersonal cues yet differ degree affective instability recent work begun elucidate neural structural functional cognitive behavioral underpinnings bpd although initial studies brain structure reached divergent conclusions avpd however almost unexamined cognitive neuroscience literature methods present study investigated group differences among bpd patients avpd patients healthy controls structural brain volumes using voxel based morphometry vbm five anatomically defined regions interest amygdala hippocampus medial prefrontal cortex mpfc dorsolateral prefrontal cortex dlpfc anterior cingulate cortex acc also examined relationship individual differences brain structure self reported anxiety affective instability group results observed reductions mpfc acc volume bpd relative significant difference among patient groups group differences amygdala volume found however bpd avpd patients showed positive relationship right amygdala volume state related anxiety contrast inverse relationship mpfc volume state trait related anxiety well bilateral dlpfc volume affective instability limitations current sample sizes permit examination gender effects upon structure symptom correlations conclusions results shed light potentially protective compensatory aspects brain structure populations namely relatively reduced amygdala volume relatively enhanced mpfc dlpfc volume published elsevier
paper deals problem robust stability analysis grid connected converters lcl filters controlled digital signal processor subject uncertain grid inductance model uncertain continuous time plant digital control gain discretization procedure described terms taylor series expansion employed determine accurate discrete timemodel linear matrix inequality based condition proposed assess robust stability polynomial discrete time augmented system includes filter state variables states resonant controllers delay digital control implementation means parameterdependent lyapunov function proposed strategy main advantage provide theoretical certification stability uncertain continuous time closed loop system circumventing main disadvantages previous approaches employ approximate discretized models neglecting errors numerical simulations illustrate benefits discretization technique experimental results validate proposed approach
aimictal epileptic headache ieh rare underestimated epileptic form characterised epileptiform discharges headache attacks without ictal sensory motor manifestations ieh difficult diagnose epileptiform discharges registered headache attack headache disappear intravenous administration anti epileptic drug according last diagnostic criteria study explored clinical neuro physiological therapeutic features ieh paediatric population methodswe analysed two novel cases adolescent female patients chronic headache long history unsuccessful analgesic oral therapy without ictal sensory motor events also reviewed entire literature paediatric ieh resultsthe clinical history diagnostic process led highly suspect ieh patients successful therapy oral anti epileptic drugs namely topiramate ethosuximide resolved chronic headache enforced diagnostic hypothesis literature review highlighted rarity ieh clinical reports particularly paediatric population mainly due stringent diagnostic criteria conclusionour study sheds light ieh paediatric population importance diagnostic electroencephalograms clinical management paediatric patients suffering chronic headache
propose novel variational approach depth defocus problem quality methods strongly depends modelling image formation forward operator connects depth focus blur therefore discuss different image formation models design forward operator preserves essential physical properties maximum minimum principle intensity values allows approximate thin lens camera model better way previous approaches forward operator refrains equifocal assumptions fits well variational framework additionally extend model multi channel case show benefits robustification cope noisy input data embed method joint depth defocus denoising approach minimisation energy functional show advantages multiplicative euler lagrange formalism two aspects first constrains soltition plausible positive range second able develop semi implicit gradient descent scheme higher stability range synthetic experiments confirm achieved improvements experiments real data illustrate applicability overall method elsevier rights reserved
objective evidence reveals link poor physical health suicide physical health rural adult psychiatric outpatients history suicide examined methods medical records patients seen tertiary level academic medical center examined demographics psychiatric medical history self reported measures depression anxiety childhood trauma health status results subjects endorsed history suicide attempts evidenced medical conditions made suicide attempt conclusions results support hypothesis increased health risks patients history suicide attempts highlight need targeted health interventions
control ups inverters special importance applications high quality output voltage needed several control schemes proposed control three phase inverter paper presents simple powerful control scheme using model predictive control mpc uses discrete time model system predict behaviour output voltage possible switching states generated inverter cost function used selecting optimal switching state applied next sampling instant simulation results linear nonlinear loads presented using matlab simulink tools verifying feasibility good performance proposed control scheme finally experimental results presented using hil simulation verify feasibility good performance proposed mpc realistic conditions
underground spaces normally cooler air temperature ambient air temperature earth sheltered walls cooler air circulated occupied spaces using solar chimney effect exhaust air basement needed work aims study viability using natural ventilation induced trombe wall draw fresh air underground basement floors space cooling dry desert climate outdoor air delivered basement earth tube numerical model integrating thermal models basement space occupied zone trombe wall used predict air temperature variation time occupied space air temperature predict thermal comfort feasibility implementing proposed system assessed case study residence inland dry desert climate lebanon summer found proposed system achieved thermally comfortable conditions acceptability considerable number hours without need mechanical ventilation june august electric energy consumption system summer june september estimated floor area american society civil engineers
purpose study determine pediatric nurses decide ethical issues sample cases evaluate issues terms ethical principles well determine problem solving approaches recommend regard qualitative methods used study data collected pediatric nurses using demographic data form open ended questionnaire demographic data form included questions characteristics nurses participation decisions made ethical issues whereas open ended questionnaire consisted questions regarding sample cases developed investigators using current literature forty four percent pediatric nurses reported attempt solve ethical issues encountered professional experiences using personal values hand pediatric nurses stated decisions sometimes taken consideration treatment plan patients reported could participate decision making regarding patients discharge seventy six percent pediatric nurses define ethical issues three sample cases however cases nurses evaluated ethical issues correctly recommended correct approaches statistically significant difference found educational backgrounds professional experiences ethical issues evaluated approaches recommended problem solving recommended nurses receive undergraduate service ethics training order develop appropriate approaches toward ethical issues encounter professional lives
long span bridges deform quasi statically dynamically range operational conditions including wind traffic thermal loads varying patterns different timescales different amplitudes external loads internal forces rarely measured well developed technologies measuring deformations time space derivatives performance data checked design limits used validating conceptual numerical models turn used estimate external loads internal forces changes performance patterns load response relationships also used directly diagnostic tool excessive deformations also concern terms serviceability paper describes application range measurement technologies focusing response extreme loads suspension bridges river tamar main span humber man span effects vehicular thermal wind loads different structures compared showing apart rare extreme traffic wind loads temporal spatial temperature variations dominate quasi static response observations deformation data sensor performance two bridges used highlight limitations redundancies instrumentation
microgrid concept provides appropriate context installing distributed generation resources providing reliability power quality sensitive loads literature analyzed effects different power control strategies inverter based distributed energy resources stability microgrids addressed various load models formulation analysis paper proposes well structured formulation state space representation comprehensive static dynamic load models islanded microgrids environment impact considering induction motor models root loci eigenvalues analyzed sensitivity calculation performed account effect different load model parameters system oscillatory modes
study investigates relation age stereotypes perceived age discrimination existing evidence relation notoriously ambiguous regard direction age stereotypes predict perceived discrimination experiencing discrimination may also change views ageing used dataset two waves disentangle direction associations considering research multi dimensionality views ageing perceived age discrimination addressed question domain age group specific perspective drawing data two measurement points german ageing survey deas age range years participants examined reciprocal relations views ageing perceived age discrimination cross lagged models revealed domain specific views ageing predict subsequent changes perceived discrimination corresponding domains negative views ageing regarding personal competence physical decline social interactions associated increases perceived discrimination domains work medical care social life respectively however find evidence reciprocal effect perceived age discrimination views ageing sum results indicate negative views ageing act self fulfilling prophecies predisposing people categorize people behaviour age discrimination act way might elicit ageist behaviour others
purpose worldwide number obese persons continues grow online mediated self help groups represent opportunity obese persons support aim study evaluate whether use active participation online self help groups associated perceived informational emotional support among obese adults methods conducted online based questionnaire users online self help groups obese adults germany results findings revealed forum activity significantly correlated perceived informational emotional support asking questions strongly correlated types social support sharing opinions answering posts strongly correlated perceived emotional support conclusion level social support online communities depends individual forum activity findings offer foundation professionals health care sector enhance understanding make recommendations develop online self help groups elsevier rights reserved
aim investigate childhood abuse victimization relation adult dna methylation levels novel region nrc emotional support possible modifier materials methods participants black women health study multivariable linear regression models used compute differences mean percent methylation levels results women reporting childhood abuse victimization exhibited higher mean nrc methylation levels nonabused women clear dose response relationship childhood emotional support appeared attenuate associations among women highest levels physical sexual abuse conclusion nrc mean methylation higher among women reported childhood abuse research warranted clarify whether extent childhood emotional support buffers association
beta hydroxy beta methylbutyrate hmb commonly supplemented maintain muscle elderly clinical populations potential nootropic previously shown male female rats long term hmb supplementation prevents age related dendritic shrinkage within medial prefrontal cortex mpfc improves cognitive flexibility working memory performance age sex specific study explore cognitive effects assessing visuospatial learning memory morris water maze female rats ovariectomized months age model human menopause months age male female rats received relatively short long term month dietary hmb dose supplementation twice day prior testing spatial reference learning memory assessed across four days water maze four trials daily probe trial last day consistent previous work age related deficits water maze performance sexes however deficits ameliorated hmb treated males training sexes probe trial performance thus hmb supplementation prevented age related decrement water maze performance especially male rats elsevier inc rights reserved
research visual nonverbal aspects political communication experiencing renaissance sorts expanding boundaries already innovative dynamic branch cross disciplinary scholarship articles assembled special issue represent breadth work occurring vibrant crossroads scholarly inquiry introduction discusses contribution providing overview entire issue
purpose purpose paper reveal dynamical behavior nonlinear wave searching new breather soliton cross two soliton solutions fifth order caudrey dodd gibbon cdg equation design methodology approach authors apply bilinear form extended homoclinic test approach fifth order cdg equation findings paper using bilinear form extended homoclinic test approach authors obtain new breather soliton cross two soliton solutions fifth order cdg equation shown extended homoclinic test approach help symbolic computation provides effective powerful mathematical tool solving nonlinear evolution equations mathematical physics research limitations implications research manifests structures solution nonlinear equations diversified complicated originality value methods used paper widely applied research spatial temporal characteristics nonlinear equations physics engineering technology methods also conducive people know objective laws grasp essential features development world
background examined relationships mothers sense coherence soc child social skills development among preschool children relationship mediated mother childrearing style methods mothers japanese children aged years completed self report questionnaire soc childrearing style children teachers evaluated social skills using social skills scale sss comprises three factors cooperation self control assertion results path analyses revealed mother childrearing mediated positive relationship mother soc cooperation self control assertiveness aspects children social skills additionally significant direct path mother soc self control component social skills conclusions findings suggest mother soc may directly well indirectly influence children social skills development mediating effect childrearing results offer preliminary evidence focusing support improve mothers soc may efficient effective strategy improving children social skills development
according many published literature parallel computing regarded efficient solution digital terrain analysis dta geographic information system stable credible services play irreplaceable role high performance computing especially error occurs large scale science computing paper new approach parallel dta considering performance fault tolerance proposed fast parallel computation fpr fpr owns fast self recovery ability based redundancy mechanisms compared fault tolerant methods errors application layers detected data block computation errors partitioned several sub blocks computed surviving processes concurrently improve efficiency failure recovery overlapping strategy error detection computation presented decomposing data block several logic sub blocks result error logical sub block data block detected comparing thread computing process immediately starts correct error strategy reduces time computation error detection overlapping comparing traditional computation method experiments show proposed fpr method achieve better performance efficiency fewer overhead
nowadays web services one commonly used technologies distributed system integration interoperability recently new communication technique called web sockets appeared implementing web services offer true server push mechanism paper present system based manage agent communications motivate use assistive technologies use case new web socket message transport protocol described implementation jade platform presented subscription based agent interaction use case presented along comparison web socket http message transport protocols
iter toroidal field coils required quench demanding event plasma disruption followed fast discharge central solenoid poloidal field coils correction coils event creates large heat deposition iter magnet stainless steel structures addition conductor losses order prevent quench occurring conductor cooling channels implemented coil structure tfcs remove large fraction heat deposited first integrated structure mock manufactured tested helios cryogenic test facility cea grenoble determine thermal coupling tfcs conductor actively cooled supercritical helium bar consists stainless steel casing cooling pipe glued resin casing groove winding pack ground insulation radial plate copper dummy cable conduit conductor cicc steady state well transient thermal characterizations completed may simulation results thermal hydraulic codes venecia supermagnet experimehtal data presented discussed thermal coupling helium cooling tube coil structure modelled equivalent heat transfer coefficient order simplify thermal hydraulic models comparison simplified coupling detailed coupling presented elsevier ltd rights reserved
young marsupials monotremes born immature state followed prolonged nurturing maternal lactation either pouch nest nevertheless level locomotor ability required newborn marsupials monotremes reach safety pouch nest varies considerably transferred pouch nest egg monotremes others transferred passively gravity dasyurid marsupials horizontal wriggle make peramelid didelphid marsupials others must climb vertically long distance reach maternal pouch diprotodontid marsupials present study archived sections inner ear hindbrain held bolk hill hubrecht collections museum fur naturkunde berlin used test relationship structural maturity vestibular apparatus locomotor challenges face young different mammalian groups system staging different levels structural maturity vestibular apparatus applied embryos pouch young hatchlings correlated somatic size indicated greatest body length dasyurids born immature state vestibular apparatus little otocyst stage peramelids born vestibular apparatus mature state fully developed semicircular ducts ductus reuniens forming cochlear duct saccule semicircular canals diprotodontids monotremes born vestibular apparatus mature state non eutherians semicircular canals formed maculae present vestibular nuclei brainstem yet differentiated monotremes marsupials reach later stages vestibular apparatus development mean body lengths lie within range found laboratory rodents mouse rat reaching vestibular stage
paper proposes advanced configuration power converter heliostat system traditional converter four switches replaced npc converter modulation algorithm npc converter also introduced replacement help system works many low level voltage sources output voltage flexible therefore system efficiency increases dimension battery solar panel decrease theory simulation experiment presented paper order validate configuration
stability feedback system generally characterized point variable system phase margin phase margin function system loop gain always well defined paper show obtain phase margin closed loop system response translating phase function simple algebraic relation method utilizes closed loop result exact algebraic translation results complete fully accounting loading effects feed forward feedback reverse transmission active elements
deployment renewable energy technologies solar photovoltaics wind turbines poses challenges terms electricity grid stability due intermittent nature energy sources creates need innovative storage solutions demonstrate metal hydride based hybrid electrochemical system enables solid oxide fuel cell operate fuel cell mode battery mode allowing interrupted electricity generation fuel cell mode device acts conventional fuel cell converts chemical energy stored fuels electrical energy battery mode metal hydride near anode releases hydrogen quickly responds fuel supply interruption power demand surges concept demonstrated promising way provide robust economical solution balancing power supply demand electrical grid future
use symbolic computation homological perturbation hpt compute resolution integers integer group ring fundamental group klein bottle easy read homology klein bottle well information
previous study five different secretory proteins including gsn adamtsl calr ppia txn identified associated nasopharyngeal carcinoma npc metastasis work proteins investigated bioinformatics analysis suggested might play important role process npc development western blotting analysis showed targets could secreted extracellular high metastatic npc cells non metastatic npc cells except gsn expressions adamtsl calr ppia txn proteins extracts cells significantly different thus expressions differentially expressed proteins tested cohort npc tissue specimens results indicated expression levels adamtsl txn highly correlated lymph node distant metastasis npc patients moreover enzyme linked immunosorbent assay elisa used investigate concentrations adamtsl txn serum specimens npc patients results revealed serum adamtsl expression level closely correlated lymph node metastasis clinical stage npc patients able discriminate metastasis npc non metastasis npc sensitivity specificity present data show first time adamtsl txn may novel potential biomarkers predicting npc metastasis furthermore serum adamtsl could potential serum tumor biomarker prognosis npc
autism spectrum disorders asd characterized difficulties social interaction verbal nonverbal communication development maintenance interpersonal relationships result individuals asd increased risk bullying victimization compared typically developing peers paper reviews literature emerged past decade regarding prevalence bullying involvement asd population well associated psychosocial factors directions future research suggested including areas research currently unexplored underdeveloped methodological issues defining measuring bullying well informant validity reliability considered implications intervention discussed
backgroundif left untreated obsessive compulsive disorder ocd cause significant distress impact functioning throughout lifespan despite severity disorder often significant delay onset symptoms successful treatment part due delays recognising ocd symptoms young people particularly symptom forms less common ocd accurately diagnosed cognitive behavioural therapy cbt known efficacious treatment sometimes combination medication producing good long term prognosis therefore important accurately detect ocd children young people offered timely intervention use best tools clinical research settings improves detection diagnosis well enabling tracking progress treatment aim current paper review measurement tools ocd young people focus practicalities using tools busy child mental health clinical settings methodto discover measurement tools available ocd young people conducted pragmatic literature measurement tools ocd young people searched psycinfo med line cochrane databases reports relating measurement ocd additionally sought information national institute health care excellence nice guidance child outcomes research consortium corc website children young people improving access psychological therapies cyp iapt programme also reviewed large trials meta analyses treatment ocd young people communicated relevant researchers clinicians resultsseventeen questionnaire measurement tools variable psychometric properties four commonly used semistructured clinician administered interview measures identified conclusionsthere several measurement tools good psychometric properties useful initial screening identification ocd well formal diagnosis symptom tracking treatment evaluation availability brief screens well online diagnostic measures tools burden clinical practice rather helpful aid support clinicians assessment treatment ocd
paper focus interconnected trajectory optimization two sets solenoid actuated butterfly valves dynamically coupled series system undergoes different approach angles pipe contraction typical profile called smart valves network containing tens actuated valves high fidelity interconnected mathematical modeling process derived reveal expected complexity multiphysics system dealing electromagnetics fluid mechanics nonlinear dynamic effects coupled operational optimization scheme formulated order seek efficient trajectories interconnected valves minimizing energy consumed enforcing stability physical constraints examine various global optimizationmethods including particle swarm simulated annealing genetic gradient based algorithms avoid trapped several possible local minima effect approach angles pipeline contraction amount energy saved discussed detail results indicate substantial amount energy saved intelligent operation uses flow torques augment closing efforts
paper problems disadvantages china current tutorial system objective training professional degree graduate students analyzed graduate student training model school enterprise cooperation model discussed combining domestic foreign studies tutor teams finally construction management evaluation index system double tutorial system professional degree graduate students proposed
last years substantial gains made understanding human memory errors phenomenon false memory wherein individuals remember entire events happen research established false memories consequential emotional last long periods time merely product demand characteristics recovery extant hidden memories recent advances discussed extensions earlier foundational research
background congenital heart disease chd common congenital malformations high mortality morbidity prevalence chd reported previously ranged per live births per live births cross sectional study aimed document prevalence chd langfang district hebei province china analyzing data collected hospitals located counties district supported public health campaign methods total consecutive month old infants included july july structural abnormalities diagnosed based echocardiography findings including two dimensional color doppler echocardiography results results infants found cardiac structural abnormalities total prevalence chd per live births value significantly higher previously reported prevalence cases per live births top five common cardiac abnormalities follows atrial septal defect asd cases ventricular septal defect cases parts per thousand patent ductus arteriosus cases parts per thousand pulmonary stenosis cases parts per thousand tetralogy fallot cases parts per thousand chd prevalence differed gender study chi majority asd cases females regional differences prevalence also found chi higher prevalence found urban areas cases per live births rural areas cases per live births significant difference prevalence chd preterm versus full term infants chi prevalence chd infants maternal aged years significantly higher chi conclusions prevalence chd langfang district within range reported using echocardiography echocardiography used early diagnose chd
purpose analyzing managing urban water pollution discharge systems uwpds comprehensively systematic approach tracking tracing analyses developed based environmental systems analysis theory directed graph nodal flow balance network analysis geographic information system gis used based digitalized uwpds gis established collecting processing large amount topographic sewage discharge drainage data scientific approach applied make tracking tracing analyses wastewater treatment plants pumping stations illicit sewage outlets pollution sources drainage pipelines systematically upstream downstream information sources discharging paths flow quantities final destinations pollutants obtained potential problems uwpds analysis illicit connections different drainage pipelines identified spatial analysis developed approach tested using uwpds chaohu city anhui province china study results important implementation sewage interception engineering determination load reduction optimization drainage pipelines pumping stations future
vulvar lymphedema uncommon disabling side effect pelvic lymphadenectomy pelvic radiotherapeutic treatment invasive genital cancer lymphorrhea complication lymphedema may extremely distressing patients due requirement wear sanitary towels pain loss elasticity vulvar skin mucosa cause discomfort coitus surgical treatments lymphorrhea vulvar lymphedema secondary gynecological cancer treatments remain controversial currently considered standard therapy present study reports two cases vulvar lymphedema complicated vulvar lymphorrhea females undergone treatment cervical endometrial cancer respectively review literature also included two present cases vulvar lymphedemas refractory standard treatments including decongestive therapy manual lymph drainage elastic bandaging low stretch bandaging exercises skin care laser excision vaporization whole skin mucosal tissue vulva successfully performed treat lymphorrhea improve quality life thus present two cases indicated laser surgery may present additional therapy treatment genital lymphedema refractory treatments
security information health care environment depends much technical controls compliance policy use information awareness policy observance code conduct whilst important ensure staff respect confidentiality let alone follow measures secure records culture security must developed throughout health care community demands clear policy practical procedures relevant workplace long term programme changes introduced managed way sensitive tensions security working practises commitment senior management achieve change strong leadership within health care professions national health service begun process endorsement caldicott committee report review patient identifiable information recommendation health organisations appoint senior health care professional responsible confidentiality patient information raising political profile patient confidentiality served change rate change gear response one health care community initiative discussed lessons drawn regarding cultural change information security elsevier science ireland ltd rights reserved
present wind tunnel study focuses effects roadway wind barriers aerodynamic aeroelastic characteristics bridge decks characterized various aerodynamic shapes cross section three bridge deck sections studied streamlined semi bluff bluff sections standard high full scale wind barrier porosity placed windward leading edge bridge deck sections aerodynamic forces overturning moment determined various wind incidence angles galloping stability studied using quasi steady theory flutter derivatives determined evaluate flutter sensitivity studied bridge deck sections wind barrier comparison empty bridge deck sections experimental results indicate important features particular drag force coefficient increased bridge deck sections wind barrier place feature particularly exhibited streamlined bridge deck section wind barrier alters trends values lift force coefficient influence wind barrier pitch moment particularly exhibited positive wind incidence angles characteristic bridge deck sections wind barrier influence galloping sensitivity studied bridge deck sections deteriorates dynamic stability respect torsional flutter elsevier ltd rights reserved
large number energy inefficient buildings constructed without taking account principles green building requires efficient utilization local resources work hemp peat fibres used order produce effective ecological thermal insulating material tests carried using short dishevelled hemp chopped peat fibres effective composites local renewable resources produced macro microstructures composites well hemp peat fibres shown activated peat allows getting ecological binder insulating materials hemp peat fibres orientated chaotically fibres consist many yarns investigations shown thermal conductivity natural fibres depends material density structure
background shortened life expectancy people mental illness widely known focus research policy activity date research primarily reflected perspectives health professionals limited attention views opinions closely affected voice carers particularly minimal despite policy stipulating carer participation required mental health services aim present views opinions carers regarding physical health people care methods qualitative exploratory two focus groups one individual interview conducted people identifying carers person mental illness research conducted australian capital territory data analysis based thematic framework braun clarke results two main themes interaction physical mental health carers physical mental health participants described impact mental illness treatments physical health including conclusions carers acknowledged crucial delivery high quality mental health services therefore important role play addressing poor physical health people mental illness hearing views opinions essential
background airplane headache occurs flights often appears intense short lasting headache take landing reports limited pathological mechanisms underlying occurrence headache proper diagnosis treatments would benefit identification potential pathways involved pathogenesis study aimed providing simulated airplane headache condition proxy towards identification underlying mechanisms methods fourteen participants including volunteers suffering healthy matched controls recruited meeting diagnostic safety criteria based approved study protocol simulation achieved entering pressure chamber similar characteristics airplane flight selected potential biomarkers including salivary prostaglandin pge cortisol facial thermo images blood pressure pulse saturation pulse oxygen spo defined values collected flight simulation pressure chamber salivary samples analyzed elisa techniques data analysis statistical tests handled spss version results participants group experienced headache attack similar experience flight non group experience headaches data showed values pge cortisol spo significantly different group comparison non group flight simulation pressure chamber conclusion pressure chamber proved useful provoke like attack also study potential biomarkers study pge cortisol levels together spo presented dysregulation simulated attack affected individuals compared healthy controls based findings propose use pressure chamber model induce thus assess new potential biomarkers future studies
background ethnic minorities europe high susceptibility type diabetes tdm groups also cardiovascular disease cvd pregnancy considered stress test predicts future morbidity patterns women affects future health child objective review ethnic differences adiposity hyperglycaemia pre eclampsia pregnancy future risk mother obesity tdm cvd prenatal development possible influences maternal obesity hyperglycaemia pre eclampsia offspring future disease risk relevant ethnic minorities europe asian african origin design literature review results maternal health among ethnic minorities still sparsely documented higher pre pregnant body mass index bmi found women african middle eastern descent lower bmi women east south asia compared women majority population within study populations risk gestational diabetes mellitus gdm considerably higher many minority groups particularly south asians majority population increased risk apparent lower bmi younger ages women african origin higher risk pre eclampsia gdm pregnancy implies approximately seven fold higher risk tdm normal pregnancies gdm pre eclampsia increase later risk cvd asian neonates lower birth weights mostly also african neonates may translate increased risks later obesity tdm cvd foetal overgrowth promote conditions breastfeeding represents possible strategy reduce risk tdm mother child conclusions ethnic minority women europe asian african origin offspring seem increased risk tdm cvd currently future pregnancy important window opportunity short long term disease prevention
autoimmune diseases often share common susceptibility genes genetic variants associated susceptibility systemic lupus erythematosus also associated autoimmune diseases linked variant positioned exon ccdc gene encoded protein functions regulation kappa master regulator immune response aim study investigate whether polymorphism may general susceptibility factor autoimmunity evaluated case control association occurrence different autoimmune diseases including new data systemic lupus erythematosus previous genome wide association studies gwas though analyse chromosome psoriasis celiac disease crohn disease ulcerative colitis multiple sclerosis vitiligo type diabetes rheumatoid arthritis ankylosing spondylitis cases patients affected amyotrophic lateral sclerosis type diabetes also included study detected nominal significant associations systemic lupus erythematosus additive model test vitiligo psoriasis one two studies multiple sclerosis results suggest associated risk several autoimmune diseases european populations specifically diseases present among else skin european federation immunological societies published elsevier rights reserved
smart materials emerging category multifunctional materials physical chemical properties controllably altered response external stimulus combining standard properties advanced material unique ability recognize adapt response change environment materials finding applications areas sensing drug delivery majority materials responsive physical chemical changes particularly exciting area research seeks develop smart materials sensitive specific molecular biomolecular stimuli systems require integration molecular recognition probe specific target molecule interest ease synthesis labeling low cost stability dna aptamers make uniquely suited effectively serve molecular recognition probes novel smart material systems review highlight current work area aptamer based smart materials prospects future applications
non linear velocity dependent rolling friction coefficient rigid ball soft surface determined instrumenting ball triaxial gyroscope converting spin rate translational velocity latter differentiated numerically resulting translational acceleration normalised gravitational acceleration order obtain rolling friction coefficient rolling friction coefficient rigid sphere foam surface increased velocity consisted three components sharp increase friction coefficient slow velocities starting static rolling friction coefficient constant coefficient medium velocities coefficient increasing velocity squared higher velocities authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
long term northern hemisphere daily snow cover extent sce product jasmes developed application consistent objective snow cover mapping algorithm data historical optical sensors polar orbiting satellites conventional decision tree algorithm multiple threshold tests employed analyze radiances five spectral bands available across full analysis period accuracies analyzed sce maps evaluated situ snow data measured ground stations along sce maps national oceanic atmospheric administration climate data record noaa cdr product evaluation showed jasmes product temporally stable producer accuracy omission error noaa key factor analysis long term sce trends comparison seasonal sce trends two products showed noaa opposite trends jasmes fall winter seasons overestimated sce decreasing trends spring summer tendencies consistent increasing spatial temporal resolutions information time used generating noaa snow analysis estimation unbiased sces based accuracies sce maps also endorses long term trends jasmes product jasmes seasonal sce exhibited negative slopes seasons statistically significant summer jja fall son delayed snow cover onset observed main driver decreasing annual snow duration scd trends spatial pattern annual scd trends exhibited noticeable asymmetry continents largest significant decreases observed western eurasia relatively statistically significant decreases north america authors published elsevier inc
paper presents novel prognostic method allows proper characterization uncertainty associated evolution time nonlinear dynamical systems method assumes state space representation system well availability particle filtering based estimates state posterior density moment prognostic algorithm executed proposal significantly improves particle filtering based prognosis frameworks currently available two main aspects first provides correction expression used computation time failure tof probability mass function context online monitoring schemes secondly presents method improved characterization tails tof probability mass function via sequential propagation sigma points computation gaussian mixture models gmms proposed algorithm tested validated using experimental data related problem lithium ion battery state charge prognosis elsevier ltd rights reserved
agent based simulations increasingly popular exploring understanding cellular systems natural complexity systems desire grasp different modelling levels demand cost effective simulation strategies tools context present paper introduces novel sequential distributed approaches three dimensional agent based simulation individual molecules cellular events approaches able describe dimensions position molecules high accuracy thus study critical effect spatial distribution cellular events moreover two approaches allow multi thread high performance simulations distributing three dimensional model platform independent computationally efficient way evaluation addressed reproduction molecular scenarios different scalability aspects agent creation agent interaction three approaches simulate common biophysical biochemical laws faithfully distributed approaches show improved performance dealing large agent populations sequential approach better suited small medium size agent populations overall main new contribution approaches ability simulate three dimensional agent based models molecular level reduced implementation effort moderate level computational capacity since approaches generic design major potential used event driven agent based tool elsevier inc rights reserved
although strong focus nosql databases cloud computing environments traditional relational data bases still integral part many computing services cloud two significant issues managing relational database cloud environment handling inevitable evolution database schema managing changes system configuration data stored database system evolves time techniques handling issues premise databases much less feasible cloud computing environments demand efficiency elasticity scalability propose versioning system used relational databases allow new versions database schema data maintained within database production data past research versioning either handles data versioning schema changes handles focused olap xml databases paper describe mechanism storing concurrent versions data oltp database explore two different implementation alternatives versioned data storage evaluate relative merits given different workloads provide concrete description implemented within innodb storage engine default data store mysql databases present quantitative comparison two implementations innodb
paper presents design implementation digital control system modular multilevel converters based digital signal processors achieve higher system control reliability multi functionality proposed architecture built effective split control tasks involved master controller six slave controllers one six arms converter master controller handles energy flow within converter user communication using ethernet universal serial bus slave controller handles capacitors voltages balancing within arm intercommunication different boards achieved mainly optical fiber inter integrated circuit bus experiments carried verify effectiveness architecture
study evaluated effects single double triple reinforcing layers bearing capacity ratio bcr strip footing sand slope system seventy two laboratory loading tests conducted stripfooting model reinforced sand slope moreover study illustrated effects different parameters two reinforcing layers bearing capacity double reinforced sand slope bcr increased single reinforced slope soils double reinforced slope soils three layered reinforced systems double reinforced soil slopes effective spacing two reinforcing layers
inulin term applied heterogeneous blend fructose polymers found widely distributed nature plant storage carbohydrates functional food ingredient provides unique combination technological properties furthermore provides nutritional benefits results better health attenuation risk many diseases inulin neutral taste colorless thereby minimally influences organoleptic characteristics product high solubility inulin enables fortified dairy products milk drinks yogurt cheeses desserts ability inulin form cream sheared skim milk provides good mouth feel food incorporated lieu also used fat replacer several animal human studies shown inulin function prebiotic promoting good digestive health influencing lipid metabolism decreasing risk osteoporosis increasing calcium absorption inulin also found exhibit effect insulinaemia glycemia well reduce risk colon cancer breast cancer tumor growth review gives emphasis major application inulin functional health aspects
objective document use contraception representative sample australian women aged years compare methods women asked use contraception method used reason non use computer assisted telephone interviews women sampled random digit dialling landline mobile phones participation rate results weighted sample heterosexually active women interviewed using method contraception including sterilisation amounts women aged using method pregnant wanted baby said partners infertile currently intercourse past menopause apparently risk unintended pregnancy used method used oral contraceptives condoms sterilisation primary method use condoms intrauterine devices implants emergency contraception increased since use sterilisation fallen method used varied age group location occupational group relationship status parity third women ever used emergency contraception highest rate among women conclusion australian women access wide range effective contraceptive methods implications given high levels use unintended pregnancies australia likely attributable method failure inconsistent use elsevier inc rights reserved
background increasing frequency addiction conceived brain disease accounts seem especially pertinentwith regard rapid delivery nicotine brain via cigarette smoke moreover drug administration trials cigarette puffs suggest behavior smoking becomes automatized individuals developing prototypical approaches smoking cigarette compared presumably social activities drinking alcohol may little opportunity social processes influence smoking behavior however survey research examining smoking motivation often reveals broadly defined social factor field research suggests social context influence smoking argument posit laboratory smoking research largely ignored social contextual factors may help understand better precise mechanisms underlying smoking behavior smoking motivation method reviewed laboratory studies examining effect social context operationalized modeling smoking behavior studies identified searching psychinfo medline using following keywords smoking nicotine tobacco cigarette consumption topography puff smoking behavior cigarettes smoked modeling imitation social context social influence peer pressure reference citation lists studies searched identify additional studies conclusions laboratory smoking studies target social context studies indicate smoking behavior influenced presence others also evidence social context influences effects smoking well processes related self perception self regulation reinforce smoking hamper smoking cessation efforts
end end learning machines enable direct mapping raw input data desired outputs eliminating need hand crafted features despite less engineering effort hand crafted counterparts learning machines achieve extremely good results many computer vision medical image analysis tasks two dominant classes end end learning machines massive training artificial neural networks mtanns convolutional neural networks cnns although mtanns actively used number medical image analysis tasks past two decades cnns recently gained popularity field medical imaging study compared two successful learning machines experimentally theoretically purpose considered two well studied topics field medical image analysis detection lung nodules distinction benign malignant lung nodules computed tomography thorough analysis used optimized mtann architectures distinct cnn architectures different depths experiments demonstrated performance mtanns substantially higher cnn using limited training data larger training dataset performance gap became less evident even though margin still significant specifically nodule detection mtanns generated false positives per patient sensitivity significantly lower best performing cnn model false positives per patient level sensitivity nodule classification mtanns yielded area receiver operating characteristic curve auc significantly greater best performing cnn model auc thus limited training data mtanns would suitable end end machine learning model detection classification focal lesions require high level semantic features
stormwater runoff infiltration brings concerns regarding potential impact soil ground water quality besides fate contaminants source control devices somewhat suffers lack documentation present study dedicated assessing spatial distribution three heavy metals copper lead zinc surface soil ten small scale infiltration facilities along several physical parameters soil moisture volatile matter variable thickness upper horizon high resolution samplings situ measurements undertaken followed ray fluorescence analyses spatial interpolation highest metal accumulation found relatively narrow area near water inflow zone concentrations markedly decreased increasing distance maximum enrichment ratios amounted contaminated sites heavy metal patterns give time integrated vision non uniform infiltration fluxes sedimentation processes surface flow pathways within devices element indicates lateral extent contamination mainly controlled hydraulics evidenced spatial structure soil concentrations restricts area remediation measures would necessary systems suggests possible optimization hydraulic functioning towards easier maintenance heterogeneous upper boundary conditions taken account studying fate micropollutants infiltration facilities either mathematical modeling soil coring field surveys elsevier rights reserved
previous meta analyses shown psychotherapy improves gastrointestinal symptoms adults irritable bowel syndrome ibs however impact functioning daily activities unknown meta analysis used estimate effect psychotherapy mental health daily functioning adults ibs extensive literature search located eligible randomized controlled trials rcts providing outcome data mental health rcts providing data daily functioning compared mixed group control conditions psychotherapy produced significantly greater improvements mental health bar daily functioning bar cognitive behavior therapy cbt evaluated largest number trials trials followed hypnosis trials psychodynamic trials relaxation trials psychotherapeutic modalities comparable respect effect mental health cbt produced greatest improvements daily functioning effect significantly larger produced relaxation therapy results important clinical implications treatment adults ibs authors published elsevier ltd
sesquiterpene lactones stls large structurally diverse group plant metabolites generally found asteraceae family stls exhibit wide spectrum biological activities generally accepted major mechanism action alkylation thiol groups biological molecules guaianolides one various groups stls anti tumour anti migraine effects allergenic agent inhibitor smooth muscle cells meristematic cell proliferation commonly reported activities stls amphibians fully grown ovarian oocytes arrested beginning meiosis stimulus progesterone meiotic arrest released meiosis progresses metaphase process known oocyte maturation previous records inhibitory effect dehydroleucodin dhl guaianolide lactone progression meiosis also shown dhl dihydroderivative dhl mixture epimers act blockers resumption meiosis fully grown ovarian oocytes amphibian rhinella arenarum formerly classified bufo arenarum aim study analyze effect four closely related guaianolides dhl achillin desacetoxymatricarin estafietin possible inhibitors meiosis oocytes amphibians vitro discuss structure activity relationships found inhibitory effect meiosis resumption greater lactone two potentially reactive centres either alpha beta alpha beta diunsaturated cyclopentanone moiety epoxide group plus exo methylene gamma lactone function
objective male hypogonadism common disorder associated low bone density poor muscle mass anemia sexual dysfunction endocrine society recently published clinical practice guideline testosterone therapy androgen deficient men treatment frequently initiated adolescence goal quality improvement initiative assess whether pediatric endocrinologists large tertiary care center follow guidelines identify opportunities improvement design performed retrospective chart review boston children hospital inclusion criteria follows current age years diagnosis hypogonadism testosterone replacement therapy data collected current age age treatment initiation diagnoses pre treatment testosterone levels route testosterone administration dose bone density hematocrit levels adherence therapy results fifty nine patients included fourteen prescribed lower testosterone doses recommended clinical practice guideline seven pre treatment testosterone levels treatment levels patients treatment testosterone levels least one value lower adult reference range ten men low testosterone levels dose adjustments thirty seven patients dual energy ray absorptiometry scans hematocrit levels conclusions pediatric endocrinologists review consistently follow clinical practice guideline testosterone therapy hypogonadal adult males strategies improve adherence guidelines could help maximize benefits therapy minimize treatment associated risks
dzhafarov kujala introduced contextual probability theory called contextuality default based three principles first principles states random variable automatically labelled conditions recorded aim article relate principle block structured computer programming languages variables declared local construct called scope scopes syntactic constructs correspond notion condition used way variable declared two scopes safely overloaded meaning label preserve two distinct identities without need label variable condition advocated means examples notion probabilistic program program introduced based scopes semantics programs illustrated using well known relational database language sql provides efficient understandable operational semantics core issue addressed construct single probabilistic model various interim probability distributions returned syntactic scope purpose probabilistic variant natural join operator relational algebra used glue together interim distributions single distribution generally article attempts connect contextuality probabilistic programming means relational database theory published elsevier inc
aim epigenetic mechanisms critical normal immune development epigenetic alterations might therefore possible contributors immune diseases investigate dna methylation whole blood associated total allergen specific ige levels methods performed epigenome wide association study investigate association dna methylation ige level allergen specific ige self reported immune diseases allergies individuals results identified replicated cpg sites associated ige mapping biologically relevant genes including acot ilra kcnh prg epx total loci associated allergen specific ige none cpg sites associated self reported allergies immune diseases conclusion study shows ige levels associated dna methylation levels numerous cpg sites might provide new leads investigating links ige allergic inflammation
background executive functions important role human behavioural regulation determinant eating behaviour aim study different components executive functions obese individuals waiting clinical treatment comparing normoweight subjects similar socio demographic characteristics method total adults obese normoweight completed neuropsychological battery included tasks conceptualization abstraction motor programming response maintenance inhibition resistance problem solving cognitive flexibility verbal fluency results statistically significant difference groups dimensions executive functions evaluated obese group showing poorer performance compared normoweight conclusions obese individuals demonstrated poorer executive functions normoweight individuals
combination large range motion insufficient bony stabilization makes glenohumeral joint susceptible injuries including dislocation young athletes magnetic resonance arthrography arthrography computed tomography arthrography arthrography play important role preoperative workup labroligametous injuries paper illustrates arthrography arthrography findings acquired time subjects illustrate common causes sequelae shoulder instability teaching points arthrography arthrography equivalent slap full thickness rotator cuff tears arthrography superior evaluating osseous defects cartilage surface lesions arthrography superior evaluating intrasubstance extra articular tendinous injuries
schizophrenia serious mental disease high mortality rate severe social consequences due insufficient knowledge etiopathogenesis curative treatments available one promising new research concepts mild encephalitis hypothesis schizophrenia developed mainly karl bechter norbert willer according hypothesis significant subgroup schizophrenia patients suffer mild chronic form encephalitis markedly different etiologies ranging viral infections traumas autoimmune diseases inflammatory process thought occur beginning course disease article investigate consequences mild encephalitis hypothesis schizophrenia scientific community evaluate consequences ethically mild encephalitis hypothesis implies schizophrenia would longer considered incurable psychiatric disorder instead would considered chronic treatable neurological disease paradigm shift would doubtlessly significant consequences major reforms would necessary theoretical conceptualization schizophrenia would challenge psychiatric diagnostic systems diagnostic statistical manual mental disorders version icd psychotic patients treated interdisciplinary teams optimally neuropsychiatric units additionally specialists endocrinology diabetology cardiology consulted frequently occuring somatic comorbidities current diagnostic procedures therapies would modified significantly might repercussions pharmaceutical industry well first old drugs expired patent protection could partly replace expensive drugs second would demand development new anti inflammatory drugs legal evaluation compulsory treatment orders might reconsidered light causal therapies leading increased legal approval reduced need compulsory treatment orders due better patient compliance social inclusion patients might improve treatment became effective regarding cognitive social functioning stigmatization patients relatives might decrease
motivated large number vertices future technologies put front path search algorithms inspired highly regular mesh structures exist domain applications paper propose new allpairs shortest paths algorithm given regular mesh topology complexity vertical bar vertical bar vertical bar vertical bar number vertices graph proposed algorithm achieve better runtime known algorithms cost narrowing scope graphs process graphs regular topology algorithm developed formalism algebraic transformations tropical algebra well known floyd warshall algorithm first prove equivalency floyd warshall algorithm tropical algebraic representation put transformations algorithm algebraic domain secondly mind structure target class graphs transform original algorithm algebraic domain develop simple low complexity iterative algorithm pairs shortest paths calculation decreasing computational complexity contribute better exploitation algorithm wide range applications hardware design new emerging technologies big data problems information technologies
background speech gestures part nonverbal communication conversations either support verbal message provide interlocutor additional information furthermore prompt nonverbal cues cooperative process turn taking present study investigated influence speech gestures perception dyadic dialogue aphasic patients particular analysed impact speech gestures gaze direction towards speaker listener fixation body parts hypothesized aphasic patients restricted verbal comprehension adapt visual exploration strategies methods sixteen aphasic patients healthy control subjects participated study visual exploration behaviour measured means contact free infrared eye tracker subjects watching videos depicting spontaneous dialogues two individuals cumulative fixation duration mean fixation duration calculated factors speech gesture present absent gaze direction speaker listener region interest roi including hands face body results aphasic patients healthy controls mainly fixated speaker face found significant speech gesture roi interaction indicating presence speech gesture encouraged subjects look speaker significant gaze direction roi group interaction revealing aphasic patients showed reduced cumulative fixation duration speaker face compared healthy controls conclusion speech gestures guide observer attention towards speaker source semantic input discussed whether underlying semantic processing deficit deficit integrate audio visual information may cause aphasic patients explore less speaker face elsevier ltd rights reserved
differential susceptibility theory proposes subset individuals exist display enhanced susceptibility negative risk promoting positive development enhancing environments experiment represents first attempt directly test assumption exposing children experimental group negative positive feedback using puppet role plays thereby serves empirical test well methodological primer testing differential susceptibility dutch children girls ages years participated examined whether negative positive feedback would differentially affect changes positive negative affect prosocial antisocial intentions behavior depending children negative emotionality results show hearing negative feedback children experimental group increased negative affect decreased positive affect strongly children control group hearing positive feedback children experimental group tended increase positive affect decrease prosocial behavior however changes response negative positive feedback depend children negative emotionality moreover using reliable change scores found support subset vulnerable children subset susceptible children findings offer suggestions guide future differential susceptibility experiments elsevier inc rights reserved
human observations behavioral studies expensive time consuming error prone reason automatization experiments highly desirable reduces risk human errors workload robotic system developed simple cheap build handles feeding data collection automatically system built using mostly shelf components novel feeding mechanism uses servos perform refill operations used robotic system two separate behavioral studies bumblebees bombus terrestris system used training bees experimental data collection robotic system reliable flight studies failing due technical malfunction data recorded easy apply analysis software hardware design open source development cheap open source prototyping platforms recent years opened many possibilities designing experiments automatization reduces workload also potentially allows experimental designs never done dynamic experiments system responds example learning animal present complete system hardware software used various experiments requiring feeders collection visitation data use system limited particular experimental setup even species
climate control applications form heating cooling account significant portion energy consumption buildings transportation consequently improved efficiency climate control systems significantly reduce energy consumption greenhouse gas emissions particular leveraging intermittent continuous sources waste heat solar energy thermally driven energy storage systems climate control play crucial role demonstrate concept thermophysical battery operates storing thermal energy subsequently releasing provide heating cooling demand taking advantage adsorption desorption evaporation condensation mechanisms thermophysical battery high power density rechargeable energy storage system investigated thermophysical battery detail identify critical parameters governing overall performance detailed computational analysis used predict cyclic performance exposed different operating conditions thermodynamic cycles addition experimental test bed constructed using contemporary adsorptive material nax zeolite demonstrate concept deliver average heating cooling powers respectively maximum power densities specific powers observed heating cooling respectively making thermophysical battery competitive stateof art climate control systems provide relatively lower power densities additionally opportunities development innovation especially synthesizing novel adsorptive materials thermophysical battery achieve significantly higher power densities ability function using thermal energy input compact lightweight thermophysical battery offers option address energy challenges associated rising demand climate control elsevier ltd rights reserved
landslide triggered earthquake rainstorm often results serious property damage human casualties therefore necessary establish emergency management system facilitate processes damage assessment decision making paper presented integrated approach mapping analyzing spatial features landslide remote sensing images digital elevation models dems several image interpretation tools provided analyzing spatial distribution characteristics landslide different dimensions terrain variation analysis along mass movement direction morphological analysis addition results image interpretation discussed adjusted online cooperating platform built improve coordination players involved different phases emergency management hazard experts emergency managers first response organizations mobile based application also developed enhance data exchange site investigation pilot study guanling landslide shows presented approach potential facilitate phases landslide monitoring information management hazard assessment emergency preparedness planning mitigation response
second two companion papers provide overview mentalization based concepts techniques working seeming mindlessness intra family violence focus paper general mentalization oriented approaches specific interventions aim disrupt non mentalizing cycles generate intra family violence encourage emergence patterns family interactions provide foundation non violent alternatives various playful exercises activities described including taking mental state snapshots selfies sessions staging inverted role plays well using theatrical masks creating body mind maps scans make chronic relationship issues come alive session permit experiences generate safe context mentalizing take place core work continuous focus integrating experience reflection without acute awareness thoughts feelings occurring sessions mere reflection likely enable change increasing mentalizing family system family members trusting attitudes grow within outside family
smart environments sme growing combination various computing frameworks ubiquitous pervasive etc devices control algorithms complex web interactions core user facilitation number industrial domestic public areas basis application areas sme may critical terms correctness reliability safety security etc achieve error free requirement compliant implementation systems designed resorting various modeling approaches including ontology statecharts paper attempts consider correctness reliability safety security design process sme related components proposing design time modeling formal verification methodology proposed methodology covers various design features related modeling formal verification sme focusing users devices environment control algorithms interaction set requirements model checking realistic case study bank door security booth system bdsb tested results show successful verification properties related safety security desired reliable behavior bdsb copyright john wiley sons ltd
two control strategies power flow control hybrid electric vehicles hevs parallel configuration planetary gear system power coupling device internal combustion engine electric machine proposed paper aim strategies determine given driving cycle appropriate mixture power provided two engines performance measured terms fuel consumption driving cycle tracking preservation energy bank batteries also considered first strategy named pgs strategy designed around planetary gear system heuristic inspired bang bang optimal control formulations low computational load second optimal one derived pontryagin minimum principle pmp shown appropriate choice weighting parameters hamiltonian pmp strategies give similar results therefore pgs strategy corresponds feasible solution optimization problem strategies implemented real time however pgs strategy easier tune tuning strategies parameters independent driving cycle power flow control laws continuous enforce use internal combustion engine maximum possible efficiency strategies tested simulations power train hybrid diesel electric bus subjected demands four representative urban area driving cycles although optimization solutions based simplified dynamic models simulation results verified detailed dynamic models hev main subsystems allows evaluate accuracy results verify hypothesis established optimization formulation simulation results indicate strategies attain good fuel consumption reduction levels
introduction mild traumatic brain injury common condition childhood although classified mild post concussive symptoms may persist interfere daily activities established guidelines exist respect follow medical care children may delay receiving appropriate care developed follow program screen persistent symptoms necessary refer patients medical assistance methods july december eligible children aged years presented sustaining mild traumatic brain injury included patients received phone call weeks period months schoolteacher parents asked complete questionnaire results discussed monthly multidisciplinary team results total children enrolled follow program headache common acute symptom upon presentation overall patients problems either weeks months patients referred special care common persistent post concussive symptoms headache cognitive problems behavioural problems period two years review patient charts revealed problems resolved conclusion one fifth children exhibit post concussive symptoms mild traumatic brain injury education patients caregivers follow visit needed applied appropriate care early stage minimise physical mental problems european paediatric neurology society published elsevier ltd rights reserved
volume measurement system based unmanned aerial vehicle uav platform designed paper solve problems long measuring period low accuracy high cost process material volume measurement system mainly consists unmanned aerial vehicle uav laser scanner inertial measurement unit differential positioning system wireless transmission equipment microcontroller uav performs measurement tasks specified measurement area planned routes measured data returned ground station system calculate coordinates measured point build stack model based triangular grid modeling method finally ground station system calculates volume produce three dimensional map measured stock characteristics system strong adaptability environment short measurement period high accuracy
triamcinolone acetonide classified glucocorticoid prohibited list published world anti doping agency caused prohibited competition administered orally intravenously intramuscularly rectally minimum required performance level mrpl detection identification glucocorticoids common local injection routes intraarticular intratendinous intrabursal injection prohibited purpose study analyze triamcinolone concentrations urine single injection patients determine would produce positive result study performed patients sports injuries joint pains administered locally doses varied samples extracted using solid phase extraction column followed hydrolysis liquid extraction using diethyl ether elution solvents collected dried dried residue reconstituted assayed performing liquid chromatography tandem mass spectrometry positive ionization mode using electrospray ionization multiple reaction monitoring acquisition mode results demonstrated concentrations urine exceeded mrpl single local injection obtained positive results patients positive result one patient furthermore metabolic situation long acting glucocorticoid exact linear model highest concentrations appeared injection information could useful limiting misuse athletes suggest athletes aware using injections competition period obtain approval therapeutic use exemption prior using authors published elsevier ireland ltd
critical metals significantly important preparation high tech materials associated applications renewable energy sustainable materials engineering cleaner production importance together supply risk substantial extent within european union pushed recovery waste highlighted electronic waste usually end life electronic products notable secondary resource purpose distinctive features range critical metals including rareearth metals indium cobalt valuable metals copper silver gold possibly recovered electronic waste top current practices electronic waste recycling requires innovations technology breakthroughs process design order promote critical metal recovery electronic waste treatment general green sustainable significant potentials noticed hydrochemistry metallurgy technologies processes contribute development flexibility relatively high recovery rate extraction selectivity critical metals possibilities eliminating secondary waste review critical evaluation carried aspects understanding features different hydrochemistry processes recycling critical metals electronic waste identifying difficulties process implemented industrial application still originate high complexity electronic waste secondary waste generation wastewater defining circulability metals recovered recognizing potentials zero waste scheme according evaluation sustainable even zero waste processing expected achieved electronic waste treatment long term preferred reduce prevent generation electronic waste improve material efficiency whole life cycle electronic products
background objective study investigate biomechanical histological effects posterior cruciate ligament pcl medial tibial plateau methods total cadaveric human knee specimens collected grouped follows pcl intact group anterolateral bundle rupture group postmedial bundle rupture group pcl rupture group strain anterior middle posterior parts medial tibial plateau axial loading force different flexion angles measured analyzed respectively forty eight rabbits chosen animal study surgery performed one side rabbit randomly experimental group side taken control control group every rabbits culled four selected time points collect medial tibial plateau morphological histological observation results pcl rupture either partial complete may generate abnormal load parts medial tibial plateau axial loading positions noticeable time dependent degenerative histological changes medial tibial plateau observed rabbit models pcl rupture compared control group pcl rupture groups exhibited higher expression matrix metalloproteinase mmp tissue inhibitors metalloproteinase timp time points conclusions either partial complete pcl rupture may generate abnormal load parts medial tibial plateau axial loading positions may cause cartilage degeneration medial tibial plateau
modelling simulation multiphysical phenomena need considered design optimisation mechanical properties cast components order accelerate introduction new cast alloys data casting defects including microstructure features crucial evaluating final performance related properties component paper required models prediction interdendritic casting defects microporosity hot tears reviewed data calculated solidification shrinkage presented effects microporosity levels discussed numerical simulation results microporosity presented aluminium alloys using procast software calculated pressure drop interdendritic liquid observed quite significant regions high pressure drop used indicator severity interdendritic microporosity defects
paper deals new method integral transformation alternating nonharmonic periodic functions presented integral transformation serves determination circuit parameters electromagnetic phenomenon paper calculated circuit parameters means measured voltage current waveform basis ones developed kirchhoff current law kirchhoff voltage law root means square values current voltage nonsinusoidal conditions
limited investigation volume shape difference subcortical structures children adhd paucity examination influence sex findings objective study examine morphology volume shape subcortical structures association emotion dysregulation girls boys adhd compared typically developing counterparts participants included children ages years old without dsm adhd structural magnetic resonance images obtained shape analyses conducted using large deformation diffeomorphic metric mapping lddmm compared boys boys adhd showed reduced volumes bilateral globus pallidus amygdala volumetric differences structure adhd girls shape analysis revealed localized compressions within globus pallidus putamen amygdala adhd boys relative boys well significant correlations increased unique subregion expansion right globus pallidus putamen right amygdala findings suggest sexually dimorphic pattern differences subcortical structures children adhd compared children possible neurobiological mechanism boys adhd demonstrate increased difficulties
aim study explore relation mothers parenting stress functioning hypothalamic pituitary adrenal axis hpaa expressed daily salivary cortisol concentrations children diagnosed attention deficit hyperactivity disorder adhd seventy five children aged years diagnosed adhd predominant hyperactive impulsive combined adhd inattentive symptoms adhd healthy peers mothers participated study mothers completed measures assessing children adhd status perceived parenting stress parenting stress index short form psi mothers symptoms psychopathology social support socioeconomic status children salivary cortisol samples collected six different time points single day mothers children adhd reported higher levels parenting stress mothers children adhd controls psi subscales showed significant associations children cortisol awakening response car adhd groups exception parental distress subscale adhd group adhd groups parent child dysfunctional interaction subscale difficult child subscale psi total score significantly associated children car interrelation revealed mothers high levels parenting stress hpaa functioning children adhd population car identified sensitive peripheral measure hpaa functioning children lay summarythis study showed families children diagnosed adhd complex relation mothers high levels parenting stress children atypical hypothalamic pituitary adrenal axis functioning
volume issue journal colman dee joyce cdj used data national youth risk behavior surveys nyrbs found parental involvement laws effect probability minors abstain sex use contraception examine question augmenting nyrbs data state youth risk behavior surveys syrbs use variety identification strategies control state level time varying unmeasured heterogeneity consistent cdj find laws effect minor teen females abstinence decisions however exploit additional state policy variation unavailable cdj use non minor teens within state control group find evidence suggest laws associated increase probability sexually active minor teen females use birth control elsevier rights reserved
objective study preliminary identification heterotrophic ammonia oxidizing bacteria aob cell concentration cross sectional profile geotextile filters wastewater treatment filters thicknesses made non woven textile supplied septic tank effluent intermittently dosed filtered hydrostatic pressure cumulative loads chemical oxygen demand cod total solids respectively filters analysis reached relatively high removal efficiency organic pollution biochemical oxygen demand bod cod ammonia nitrogen removal efficiency level proved unstable biomass samples dry mass identification taken two regions continuously flooded wastewater intermittently flooded wastewater culturable heterotrophic bacteria determined colony forming units cfus microbiological selective media means plate method aob nitrite oxidizing bacteria nob examined using fish technique relatively wide range heterotrophic bacteria observed geotextile layers highest concentration heterotrophic bacteria observed first layer textile filter aob identified occasionally bacteria colonizing last filter layer occasionally much higher concentrations ammonia nitrogen efficiency achieved bacteria oxidizing nitrite nitrate observed relation total organic fraction biomass culturable heterotrophic bacteria also found
purpose dose response relationship fasting blood glucose levels risk pancreatic cancer investigated association casual blood glucose levels pancreatic cancer death examined examined association casual fasting blood glucose levels death due pancreatic cancer japanese methods performed pooled analysis individual japanese including participants aged years ten cohorts participants classified five groups low normal middle normal high normal prediabetes casual blood glucose fasting blood glucose diabetes casual blood glucose fasting blood glucose anti diabetic drug use low normal middle normal high normal defined according tertiles casual fasting normal blood glucose levels hazard ratios hrs confidence intervals cis pancreatic cancer mortality estimated stratifying casual fasting blood glucose cohort stratified cox proportional hazards regression analysis low normal casual blood glucose fasting blood glucose reference results fasting blood glucose showed dose response relationship pancreatic cancer mortality trend adjusting covariates hrs cis prediabetes diabetes however significant associations casual blood glucose tendencies observed exclusion participants censored first years follow conclusions fasting blood glucose better predictor pancreatic cancer death casual blood glucose
present first parallel demand spatial hierarchy construction algorithm targeting ray tracing many core processors gpus method performs simultaneous ray traversal spatial hierarchy construction focused parts data structure traversed method based versatile framework built around task pool runs entirely gpu show demand construction improve rendering times compared full hierarchy construction evaluate method object bvh space tree subdivision data structures compare mutually demand method particularly beneficial rendering large scenes high occlusion also present sah tree builder outperforms previous state art builders running gpu
agitation associated dementia frequently reported clinically received little attention preclinical models dementia current study used intracerebroventricular injection model alzheimer disease assess acute memory impairment bilateral intrahippocampal injection model aggregated beta injections bilateral injection model dementia lewy bodies aggregated nac injections assess chronic memory impairment rat alternating lever cyclic ratio schedule operant responding used data collection incorrect lever perseverations measured executive function memory running response rates rrr measured behavioral output agitation results indicate bilateral injections beta bilateral injections nac decreased memory function increased rrrs whereas intracerebroventricular injections decreased memory function increase rrrs findings show using aggregated peptide injection models dementia induce chronic neurotoxicity memory decline accompanied elevated behavioral output demonstrates peptide injection models dementia provide preclinical screen pharmacological interventions used treatment increased behavioral output agitation also establish detrimental side effects memory wolters kluwer health inc rights reserved
study targeted permanently employed staff specific business unit campus south african university explore relationship employees perceived levels trust immediate line manager supervisor overall perceptions diversity climate within business unit south africa recently celebrated years democracy although racism discrimination place democracy current widespread unrest university campuses suggests big enduring challenges transformation easily resolved clearly much still remains done order accelerate transformation higher education system critical question arises change brought cost effective sustainable way view steadily growing incidents often violent unrest university campuses therefore seems appropriate researchers evaluate far south africa really come considering extent different business units universities able contribute towards creation prejudice free inclusive society factors might influence within environment similar organisations university diversity climate barometer extent university able establish academic environment free prejudice discrimination diversity climate institution reflects psychological perceptions attitudes beliefs individuals also translate different groups may include limited gender age racial ethnic groups interact within specific organisational context psychological behavioural indicators diversity climate affect individual organisational performance dramatic way either positive negative nature previous research studies international arena suggest address challenge change organisations develop quality relationships interpersonally organisationally inter organisationally enhanced building developing trust however easily said done especially since historical context one trust diverse groups repeatedly fractured destroyed time despite fact effective diversity management create prejudice free inclusive workplace environments becoming growing concern empirical research diversity climate still limited even fewer studies examined possible relationship diversity climate trust fact within south african context research relationship various forms trust potential influence diversity climate organisation extremely rare study took quantitative approach explore relationship dyadic trust diversity climate cross sectional survey used collect data questionnaire used study combination three previously validated instruments diversity climate defined employees perceptions policies practices communicate extent fostering diversity eliminating discrimination priority organisation diversity climate measured previously validated diversity climate assessment instrument consisted nine items study employed definition trust widely accepted across disciplines according trust defined willingness party vulnerable actions another person based expectation perform particular action important trusting party irrespective ability monitor control party trust multi dimensional interrelated complex concept dimensions used measure trust included predictors trust well evidence actual risk taking expressed trusting behaviours two previously validated measures trust combined order measure trust component comprehensive manner predictors included eight items measure trusting party propensity also known innate generalised inclination trust others items employed measure perceived trustworthiness derived indications trusted party perceived ability items benevolence items integrity items trust also measured items confirmed indicators trusting behaviours willingness rely items disclose information items trusted party despite lack guarantees one trust abused prior operationalisation measurement instrument translated english afrikaans sesotho possible errors identified corrected independent professional translator fluent three languages study results indicated majority employees perceive diversity climate positive agree organisation committed towards diversity management eliminating discrimination correlation analysis dimensions trust diversity climate revealed trust dimensions except propensity towards trust sort relationship diversity climate results indicated group employees education matric grade indicated higher propensity towards trust compared group either diploma post graduate degree propensity towards trust disclosure based trust dimensions revealed noticeable differences black white groups practical significance within diversity climate construct gender education ethnic employment status level employment groups regarded positive result institution paper concluded recommendations future research
modern knowledge base systems frequently need combine collection databases different formats relational databases xml databases rule bases ontologies etc deductive database system ddbase manage different formats knowledge reason even file systems different computers part knowledge base often necessary handle different versions knowledge base might want find common parts differences two versions relational database examine use abstractions rule bases predicate dependency rule predicate graphs also proof trees derived atoms help compare different versions rule base moreover might possible derivations joining rules formalisms knowledge representation ontologies shown benefits many applications intelligent systems many proposals rule languages compatible semantic web stack swrl semantic web rule language recently ontologies used hybrid systems specifying provenance different components
linguistic summaries databases provide quick insight stored data important facilities understanding grasping meaning large data collections especially relevant context big data however large data collections often suffer incomplete data case relational databases modelled called null values paper propose novel soft computing technique measuring quality linguistic summary case missing information specifically describe illustrate bipolar satisfaction degrees used model validity summary hesitation validity might caused due missing information extra information hesitation provides users semantically richer description summarization results important view correct interpretation
background laparoscopic gastrectomy reported associated faster recovery open gastrectomy however influence surgical approach initiation timing adjuvant chemotherapy remains unclear methods single institutional retrospective observational study patients pathological stage iii gastric cancer undergoing lymphadenectomy group matched patients selected similar patients undergoing group identically matching gender age pathological stage type gastrectomy comparing initiation timing two groups factors associated delayed initiation investigated multivariable analysis results performed patients median time interval significantly shorter group weeks respectively grade odds ratio confidence interval open surgery postoperative weight loss conclusions may associated shorter intervals postoperative morbidity reduced much possible elsevier ltd baso association cancer surgery european society surgical oncology rights reserved
many real world data naturally represented tensors multi dimensional arrays tensor decomposition important tool analyze tensors various applications latent concept discovery trend analysis clustering anomaly detection however existing tools tensor analysis scale well billion scale tensors offer limited functionalities paper propose blgtensor large scale tensor mining library tackles problems carefully designed scalability blgtensor decomposes least larger tensors current state art furthermore blgtensor provides variety distributed tensor operations tensor generation methods demonstrate blgtensor help users discover hidden concepts analyze trends large scale tensors hard processed existing tensor tools
water diesel nanoemulsions prepared aid high energy emulsification method formulation accomplished presence triton surfactant wide range surfactant concentration varying amount water percentage used preparation nanoemulsion fuels droplet size nanoemulsions different water surfactant diesel ratio increased surfactant concentration decreased high kinetic stability observed nanoemulsions stability nanoemulsions surfactant concentration persisted two weeks without phase separation droplet size nanoemulsions increased time proving influence breakdown processes ostwald ripening combustion characteristics nanoemulsions studied terms different formulating compositions engine test bed diesel engine used combust nanoemulsions study exhaust emission concentrations performance parameters include brake power thermal efficiency highest reduction exhaust gas emissions concentrations notified using surfactant concentration water content lowest calorific value prepared nanoemulsions achieved using surfactant concentration water highest brake power thermal efficiency also obtained surfactant concentration water content addition characteristic evaluation nanoemulsions made basis emission characteristics neat diesel observed use nanoemulsions diesel engine evidently led reduction exhaust emissions anticipating application alternative eco friendly fuel internal combustion engine energy institute published elsevier ltd rights reserved
china largest emission source power sector large scale power exchange results issue interprovincial emissions transfer embodied power transmission based interprovincial detailed power exchange data bottom method takes account fuel mix exported electricity developed calculate provincial emissions embodied power transmission provincial emissions power sector associated consumption perspective analyzed compared production based perspective calculation shows total emissions embodied interprovincial power exchange accounting total emissions power sector embodied emissions risen general transfer pathway embodied emissions eastern china western china long range power transmission disparities consumption production based emissions significant provinces production based emissions power sector inner mongolia higher consumption based consumption based emissions beijing larger production based study also reveals increasing trend emissions production consumption principles provinces period elsevier rights reserved
emergency ambulance calls represent one routes emergency hospital admissions care homes aimed describe pattern ambulance call rates care homes identify factors predicting homes calling ambulance frequently obtained data south western ambulance service nhs foundation trust ambulance calls relating people aged care homes torbay region april july supplemented data care quality commission cqc website home characteristics outcomes cqc inspections used descriptive statistics identify variation ambulance call rates residential nursing homes fitted negative binomial regression models determine call rates predicted home type nursing versus residential five standards cqc reports dementia care status travel time hospital one hundred forty six homes residential nursing included analysis number calls made ranged median number iqr range calls per resident per year nursing homes lower call rate residential homes adjusted rate ratio arr care homes failing quality suitability management standard lower call rate compared passed arr homes specialising dementia higher call rate compared specialising arr findings require replication regions establish generalisability investigation required determine extent call rate variability reflects different needs resident populations differences care home policies practice
dna methylation implicated pathogenesis schizophrenia egr considered potential candidate gerie schizophrenia conducted vitro dna methylation reaction lucia luciferase activity assay pyrosequencing assay assess dna methylation egr expression underlying pathophysiology schizophrenia found dna methylation putative egr regulatory regions attenuated lucia luciferase activity difference dna methylation pattern egr schizophrenic patients controls data suggest dna methylation regulated expression egr might associated schizophrenia
found evidence usual developmental trends children spontaneous false memories eliminated using novel stimuli containing obvious themes children created false memories adults scenes needed remembered experiment year olds higher false memory rates adults using visual scenes experiment showed gist cuing could account effect experiment children adults received visual scenes story contexts scenes embedded types stimuli found children highest false memory rates results indicate underlying theme scenes easily identified resulting developmental false memory trend elsevier inc rights reserved
background short valid instruments measuring factors facilitating hindering implementation efforts called article describes adaptation shorter version evidence based practice attitude scale ebpas items psychometric properties shortened version norwegian data methods participants mental health service providers recruited clinics providing mental health services san diego county california norwegian participants psychologists psychiatric nurses psychology students recruited norwegian psychological association norwegian nurses organization confirmatory factor analysis cfa approach used results reduction resulted items named ebpas original factor model maintained ebpas acceptable model fit indicated low degree misspecification errors rmsea srmr norwegian data rmsea srmr incremental model fit fair cfi tli norwegian samples cfi tli internal consistency cronbach norwegian samples good total ebpas score respectively ranged adequate excellent subscales norway conclusions ebpas adequate psychometric properties norwegian samples hence indicating cross cultural validity brief pragmatic user friendly instrument ebpas yet maintains broad scope retaining original measurement domains
migration health studies traditionally focused socioeconomic determinants health emerging body literature exploring migration status proximate cause health outcomes study path analysis predictors mental health amongst documented migrant workers singapore shows threat deportation one important proximate social determinants predicted mental illness mediator impact workplace conflict mental health study qualitative study narratives migrant workers workplace conflict employers demonstrates workers believed threats used negotiating strategy workplace conflicts findings suggest migration status places workers come workplace conflict employers heightened risk mental illness migration status used tool employers workplace negotiations
article explores occasions professionals law enforcement medicine find trapped amidst paradoxical demands diagnostic investigative practice juxtaposing research experiences police officers charged interviewing children alleged victims sexual abuse clinicians tasked diagnosing managing contested cases thyroid disease paper develops understanding practice paradoxes occasions stalled transition liminal hotspots drawing process theoretical understanding liminality analysis explores personal experiential affective efficacy epistemological framework practices share liminal hotspots denote paradox stalemates paper argues also responsible recurrent instants temporary affective unsettledness provoke novel thinking agency towards innovation practice areas notoriously resistant change improvement systematizing property could turn resources change
currently mobile devices people planet number likely multiply many folds internet things revolution next years may treasure unprecedented computational power especially wide spread multicore processors mobile phones paper investigates proposes new methodology mobile cluster computing multiple mobile devices including multicore processors combined perform possibly massively parallel applications paper presents details steps building testing mobile cluster using proposed methodology proving successful implementation
nasa soil moisture active passive smap satellite mission launched january provide global mapping high resolution soil moisture freeze thaw state every days using band active radar band passive radiometer level radiometer soil moisture product provides soil moisture estimates posted earth fixed grid using brightness temperature observations descending passes paper provides first comparison validated release product soil moisture products provided soil moisture ocean salinity smos aquarius advanced scatterometer ascat advanced microwave scanning radiometer amsr missions comparison conducted part smap calibration validation efforts smap smos appear similar among five soil moisture products considered paper overall exhibiting smallest unbiased root mean square difference highest correlation overall smos tends slightly wetter smap excluding forests differences observed smap aquarius compared little two months compare well especially low moderately vegetated areas smap ascat show similar overall trends spatial patterns ascat providing wetter soil moistures smap moderate dense vegetation smap amsr largely disagree soil moisture trends spatial patterns amsr exhibits overall dry bias desert areas observed wetter smap
purpose though perianal fistulas commonly seen patients crohn disease also seen patients without inflammatory bowel disease purpose study evaluate imaging differences perianal fistulas patients without crohn disease methods retrospective search january december radiology database perianal fistula yielded patients patients dedicated fistula protocol studies included whereas patients previous anal surgery anastomosis anorectal tumors equivocal findings could definitely assessed fistula excluded following features assessed anatomic type fistula parks classification luminal origin hour clock position anal verge distance signs acute inflammation circumference anus involved inflammation presence rectal inflammation abscess results one hundred twenty six patients met inclusion criteria crohn disease common fistulas identified transphincteric crohn non crohn intersphincteric crohn non crohn abscess associated cases crohn group non crohn group rectal inflammation present patients crohn disease without crohn finding statistically significant conclusions study demonstrates groups similar imaging features accompanying rectal inflammation commonly seen crohn disease
number recent studies identified overconfidence effect psychosis whereby people schizophrenia overconfident errors simultaneously slightly underconfident accurate effect may implications delusions based inaccurate inferences perceptions judgements typically held high conviction given importance overconfidence effect may accounting delusional conviction current narrative review aims summarise critique recent evidence effect within schizophrenia people schizophrenia consistently found overconfident errors slightly underconfident correct appraisals effect appears artefact poor task performance overconfidence effect linked delusion proneness general population less direct evidence linking overconfidence delusional symptoms clinical populations future studies need adopt longitudinal designs include additional measures overconfidence investigate association appropriately also investigate possible mediators postulated relationship dopaminergic activity
multiple criteria decision making mcdm process evaluating alternatives relevant decision making criteria several methods available facilitate evaluation steps paper deals rural water supply problem coastal areas bangladesh three different mcdm methods weighted summation analytical hierarchy process novel approach imprecise assessment decision environments used evaluate suitable water supply alternative ranking alternatives obtained mcdm techniques produced similar results among five water supply alternatives evaluated rainwater harvesting systems deep tube wells scored first second respectively three evaluation methods addition sensitivity analyses carried mcdm techniques results show drastic variations either finding implies selection mcdm technique important evaluating similar problems emphasis given defining problem comprehensively thus selecting relevant criteria priorities factor decision problem
contribution develop describe new adaptive pulsed laser welding method thin electrical laminations using reflective laser sensor custom made control unit appropriate software system triggers laser pulse contacts laminations way total laser pulse energy consequently specific power losses electromotor stack used significantly reduced new method great potential serial production electromotors
risks involved design construction projects several studies conducted identifying risks involved using traditional delivery method design bid build design construction projects however little research done identifying risks involved using alternative project delivery apd methods design construction water wastewater projects identification risks could assist improving project performance future projects use apd methods survey conducted identify risks involved using apd methods design construction water wastewater projects respondents survey owners policy makers utility managers project managers used apd methods water wastewater projects survey results showed top three risks using apd methods discomfort change traditional delivery method lack qualified personnel within organization loss control design process one recommended approaches provided respondents address risks educate owners policy makers project staffs regarding apd methods
objective investigate feasibility effectiveness home based exercise program tsp ham individuals methods twenty three tsp ham individuals divided two groups according timed tug score performed week home based exercise program primary outcomes exercise adherence maximum voluntary isometric contraction lower limbs mvic barthel index secondary outcomes adverse effects barriers exercise practice results mvic social functioning domain improved significantly tug group improved significantly physical functioning domain total adherence week home based exercise program mild moderate adverse events related exercise program adverse events related mvic test conclusions home based exercise program feasible effective improving disability quality life individuals tsp ham
paper addresses identification switched linear mimo state space systems proposed methodology explores use subspace identification techniques clustering data classification obtain estimate submodels main contribution work lies inclusion identification step points generated mode points classification proposed use hybrid filtering technique known interacting multiple model imm algorithm important feature overall identification algorithm matrices different submodels directly combined obtained state space basis efficiency developed method demonstrated via numerical examples
paper deals identification errors variables eiv models corrupted additive uncorrelated white gaussian noises noise free input arbitrary signal required periodic particular frequency domain maximum likelihood estimator proposed analyzed detail eiv estimators method assumes ratio noise variances known estimation problem formulated frequency domain shown parameter estimates consistent explicit algorithm computing asymptotic covariance matrix parameter estimates derived possibility effectively use lowpass filtered data using part frequency domain discussed analyzed illustrated elsevier ltd rights reserved
paper aim propose parallel multi core hyper heuristic based greedy randomized adaptive search procedure grasp permutation flow shop problem makespan criterion grasp well known two phase metaheuristic first construction phase builds complete solution iteratively component component greedy randomized algorithm local search phase improves solution choice component order added solution mostly depend incremental cost thus basic grasp configuration defined cost function probabilistic parameter greediness neighbourhood structure consider five cost functions seven well known neighbourhood structures paper cost function based bounding operator integrated grasp first time mechanisms investigate automatically algorithm configurations refer hyper heuristics hyper heuristic investigates grasp configurations reports one produces better results parallel multi core computing used way efficiently implement hyper heuristic taillard benchmark instances used test hyper heuristic permutation flow shop problem copyright john wiley sons ltd
traditional rubber hand illusion psychological experiment participants illusion rubber hand part body paper examines use real virtual augmented reality environments identifying elements influence body ownership healthy participants compared classical experiment plastic rubber hand used realistic representation chosen create illusion time immersive virtual reality augmented reality experiments performed volunteers undergoing testing session composed three stages participants asked complete two different questionnaires one measuring cognitive workload another one regarding experience rubber hand illusion addition eeg signals individuals recorded resulting electroencephalogram datasets results indicate correlations ownership statements beta gamma electroencephalogram bands premotor cortex activity link higher gamma production ventral premotor area illusion established previous studies
dynamic modeling simulation mooring system key technologies anchor handling simulator ahs built mooring line dynamics model based lumped mass method lmm fourth order runge kutta method used solve model huge amounts calculation model solving time consuming process brings great impact real time fidelity immersed feeling anchor handling scene simulation seriously hindered application ahs novel parallel algorithm proposed speed model solving process taking advantages graphic processing units gpu massive parallel computing float point computing capability model solving process implemented vertex shader based transform feedback mechanism modern gpu experimental results show new algorithm reduced calculating time largely without losing accuracy finally realize real time solving simulation
paper presents method accelerate target recognition processing advanced driver assistance systems adas histogram oriented gradients hog effective descriptor object recognition computer vision image processing hog expected replace conventional descriptors template matching adas however hog consider occurrences gradient orientation objects localized portions image region interest roi set precisely size position roi set precisely frame automotive environment target distance changes dynamically use radar determine size position roi hog propose radar camera sensor fusion algorithm experimental results discussed
wireless sensor network wsn vulnerable wired network relatively easy adversary eavesdrop insert alter intercept message communicated network sensor nodes limited power memory designing secure communication architectures main goal design energy memory efficient protocols well known communication architectures like tinysec llsp minisec compromise security issues energy memory constraints sensor nodes wsn communication consumes energy computation minimizing communication overhead energy consumption reduced propose new energy efficient secure communication architecture called eesca wsn make communication secure along authentication confidentiality integrity proposed architecture provides strong replay protection data freshness permutation substitution used generate massage authentication code eesca robust heavy packet loss reset resynchronization counter required proposed scheme energy efficient security packet overhead reduced byte best known secure communication architectures efficacy eesca shown theoretical experimental analysis copyright john wiley sons ltd
drawing basic physics kummel beaudreau attributed productivity slowdown opec price hike led decrease rate growth energy consumption mid high post wwii energy use growth rates observed oecd countries fell drastically decreasing productivity gdp growth however since considerable doubt cast view example rate growth energy use manufacturing specifically electricity use fall price electricity either unaffected increased slightly afterwards second fall instantaneously without usual lag third energy consumption growth rates return pre level real energy prices returned pre levels drawing kinetics paper presents alternative hypothesis namely energy demand related factors notably physical limits energy based speed ups energy supply related factors may behind sudden decrease productivity growth hence behind productivity slowdown specifically many industries sectors maximum machine speed velocity may near reached late early making increases physically impossible economically viable elsevier ltd rights reserved
easily perceived identities race may interact perceptually ambiguous identities sexual orientation meaningful elusive ways investigated intersecting identities impact impressions leadership people perceived gay black men better leaders members either single minority group gay black yet different traits supported judgments leadership abilities black white targets instance warmth positively predicted leadership judgments black men dominance positively predicted leadership judgments white men differences partly occurred different perceptions masculinity across intersection race sexual orientation indeed categorical race sex noncategorical trait social information contributed leadership judgments findings highlight differences traits associated leadership black white men well importance considering intersecting cues associated obvious ambiguous groups moderate perceptions
provides simultaneous benefits reducing demand potable water generation water runoff rainwater harvesting rwh received increasing attention urban water managers past decades study employs mass balance based method estimate rwh performance four large metropolitan areas united states namely new york city philadelphia chicago seattle geospatial analysis used concert climatic records characterize cityscape climatic patterns city evaluate rwh systems performance terms potable water savings roof runoff reductions analysis indicates typical urban rainwater harvesting setups consisting roof connected storage volume would able reduce potable water demand cities contextually reduce roof runoff generation small differences performance observed among cities due differences precipitation patterns typical roof area population density furthermore evaluation total water savings runoff reduction application rwh practices maximum build four study cities provided sensitivity estimates performance precipitation patterns systems operating algorithm also analyzed discussed elsevier rights reserved
helpful legal punishment neighbor help preventing parents physical child abuse real life setting uncertain suspicious question concern considering prevailing advocacy preventing child abuse community address question study examines preventive effects survey high school students chinese metropolis shanghai results reveal significant preventive effects legal punishment neighbor help physical abuse father mother respectively addition legal punishment mother tended reduce father physical abuse presence neighbor help results support ecological theory posits joint contribution complementary resources obtained different sources results imply merit orchestrating support parents neighbors legal authorities preventing child abuse elsevier ltd rights reserved
many changes occur structure properties test material drying consequence moisture evaporation use image acquisition analysis techniques proposed potential method obtaining better understanding different phenomena happen drying techniques quantify morphological textural color features materials changes occur techniques convenient use accurate facilitate rapid measurement accordingly use image acquisition analysis techniques continues attract considerable research interest field drying many techniques applied field scanning electron microscopy sem charge coupled device ccd photography neutron radiography magnetic resonance imaging mri ray tomography forth technique characteristics specific applications sem employed investigate morphological structure pore distribution sample drying form magnified images computer vision system typically uses two portable ccd cameras provide top side view images sample used online monitoring change shape color crack development sample drying mri used determination moisture profiles inside sample drying addition mri used characterize pore distribution combination technologies ray tomography provides cross sections tomographic reconstructions sample used elucidate volume crack development surface area porosity moisture profiles sample drying overall various image acquisition analysis techniques ray tomography considered one promising future field drying
understood economic terms interest elevates baser human impulses degrades higher human potential motivates individuals value material gains moral ones influence difficult consider interest regime value beleaguered mean ought abandoned especially interest placed front center constitutional order providing perspective merits interest alexis tocqueville offers conceptualization allows regime value relevant even contemporary administrators operating spaces diffused public responsibility
storage insects may cause occupational allergies humans identification prevalence ige reactions measured protein fractions prepared multiple life stage granary weevil sitophilus granarius reported sera patients suburban population upper silesia south poland tested presence ige antibodies antigens larvae pupae adults sexes beetle identify protein fractions containing potential allergens proteins collected four life stages granary weevil fractionated sds page probed anti human anti ige monoclonal antibodies proteins fractionated sds page identified western blot patients antibodies particular antigens identified using anti human anti ige monoclonal antibody conducted immunological analysis showed existence many protein fractions life stage give positive reactions ige antibodies largest number allergenic potential fractions shown pupae protein fractions smallest amount shown larvae protein fractions summarizing obtained results suggest existence many protein fractions allergenic potential multiple life stages indicates developmental stages may serious source antigens potential risk factors exposed persons elsevier ltd rights reserved
anatomical functional evidence ventral midbrain dopaminergic cell groups sub thalamic nucleus stn receive noradrenergic innervation rodents much less known interactions primates degeneration neurons locus coeruleus related brainstem cell groups well established pathological feature parkinson disease development pathology animal models inconsistent across species laboratories recently demonstrated neuronal loss cell groups rhesus monkeys rendered parkinsonian chronic administration methyl phenyl tetrahydropyridine mptp study used dopamine beta hydroxylase beta immunocytochemistry assess impact neuronal loss number terminal like varicosities substantia nigra pars compacta snc ventral tegmental area vta retrorubral field rrf stn mptp treated parkinsonian monkeys findings reveal innervation ventral mid brain stn normal monkeys heterogeneously distributed far extensive vta rrf dorsal tier snc ventral snc stn parkinsonian monkeys regions underwent significant similar decrease innervation electron microscopic level positive terminals formed asymmetric axo dendritic synapses vta stn findings demonstrate vta rrf sncd main ventral midbrain targets ascending inputs connections undergo major break chronically mpip treated parkinsonian monkeys severe degeneration ascending system may contribute pathophysiology ventral midbrain stn neurons elsevier inc rights reserved
simulation based studies sbs become interesting investigation approach software engineering however reports experiments dynamic simulation models found technical literature lack relevant information hampering full understanding procedures results reported well replicability apart limitations length conferences journal papers relevant information seems missing due methodological issues considered conducting studies case missing research questions goals lack evidence regarding dynamic simulation model validity poorly designed simulation experiments amongst others based findings previous quasi systematic literature review propose set reporting guidelines sbs dynamic models context aiming providing guidance information report contain furthermore guidelines evolved support sbs planning identifying potential threats simulation study validity making recommendations avoid qualitative analysis external evaluation finally conducted different evaluations regarding reporting planning guidelines apart using support planning sbs regards software evolution set reporting planning guidelines different stages simulation lifecycle focused experimentation dynamic simulation models put together first assessments point comprehensive set guidelines supporting comprehensive preparation review plans reports studies apart planning sbs focused software evolution potentially reducing threats experimentation validity dynamic simulation models guidelines understood separate groups reporting planning overlap many aspects main goal use guidelines support planning simulation based study dynamic models experimenters may identify potential threats validity produce relevant information complete simulation experiment report advance despite initial contribution increase validity sbs reporting planning simulation based experiments dynamic models still discussed improved therefore additional assessments set guidelines needed strengthen confidence completeness usefulness
work two methods gear rattling detection mechanical systems studied purpose experimental quick return mechanism constructed gears driven electric motor rattling detected mechanical vibrations acceleration electric motor current vibrations signal measured biaxial accelerometer electrical current obtained motor electronic driver signals processed time domain time frequency domain rattling level measured proposed performance evaluation index obtained application band pass filters rms value signal time domain processing time frequency analysis wavelet transform used isolate rattling signal post processed compute rms value shown use electric motor current detection rattling produce better results mechanical vibrations acceleration respect time domain method versus time frequency method found application wavelet transform significantly improves indexes used gear rattle detection
spontaneous massive infarction mammary gland tumors reported occur infrequently humans subcutaneous mass observed right axilla extending chest region week old female wistar hannover galas rat histopathologically well circumscribed mass lobular structures present subcutis mass occupied extensive coagulative necrosis neoplastic cells relatively uniform acinar ductal structures although necrotic acinar structure separated reticular fibers periacinar stromal collagen fibers abundant considering site occurrence histological features necrotic tissue diagnosed adenoma mammary gland necrotic region lacked hemorrhage obvious inflammatory cell infiltration indicating necrosis caused infarction although multiple necrosis focal infarction occasionally observed large sized tumors rodents especially adenocarcinomas present case characteristic massive infarction involving parts tumor despite relatively small size low atypia neoplastic cells rare case spontaneous infarcted adenoma mammary gland rats histologically resembling human cases
interleukin pleiotropic helper type cytokine frequently associated asthma atopic dermatitis mediated signalling initiated binding alpha recruits alpha form heterodimeric receptor complex also binds alpha considered either decoy key mediator fibrosis neutralising antibodies act preventing binding alpha alpha alpha tralokinumab cat neutralising human igg monoclonal antibody shown clinical benefit patients asthma decipher tralokinumab inhibits effects determined structure tralokinumab fab complex human resolution structure analysis reveals tralokinumab prevents binding alpha alpha supported biochemical ligand receptor interaction assay data tralokinumab epitope mainly composed residues helices mostly light chain complementarity determining regions driving paratope interactions variable light complementarity determining region plays key role providing residue contacts network hydrogen bonds salt bridge core binding key residues within paratope contributing binding identified asp asp ser lys study demonstrates tralokinumab prevents pharmacodynamic effect binding helices thus preventing interacting alpha alpha astrazeneca published elsevier ltd
concentration eight heavy metals surface groundwater around dhaka export processing zone depz industrial area investigated health risk posed local children adult residents via ingestion dermal contact evaluated using deterministic probabilistic approaches metal concentrations except bangshi river water drinking water quality guidelines groundwater less recommended limits concentration metals surface water decreased function distance estimations non carcinogenic health risk surface water revealed mean hazard index values combined pathways ingestion dermal contact age groups estimated risk mainly came ingestion pathway however values examined metals groundwater adult children respectively deterministic probabilistic estimations cancer risk exposure groundwater well safety limit overall population exposed bangshi river water remained carcinogenic non carcinogenic health threat risk higher adults sensitivity analysis identified exposure duration ingestion rate water relevant variables affecting probabilistic risk estimation model outcome elsevier ltd rights reserved
objective study introduces predictability framework based concept granger causality order analyze activity interactions different intracardiac sites atrial fibrillation methods based interactions studied using three electrode analysis scheme multi variate autoregressive models involved preprocessed intracardiac signals method evaluated different scenarios covering simulations complex atrial activity well endocardial signals acquired patients results results illustrate ability method determine atrial rhythm complexity track andmap propagation conclusion proposed framework provides information underlying activation regularity require activation detection postprocessing algorithms applicable analysis multielectrode catheter significance proposed framework potentially help guide catheter ablation interventions
social problem solving associated alcohol use adolescents examined within context well established risk factors childhood conduct problems parental history alcohol use association deviant peers behavior undercontrol study surveyed year old first year college students examine whether poor social problem solving risk factor adolescent alcohol use beyond well established risk factors examine whether social problem solving moderator behavior undercontrol alcohol use adolescents hierarchical multiple regressions found social problem solving significant risk factor beyond well established risk factors adolescent alcohol use furthermore social problem solving significant moderator behavior undercontrol adolescent alcohol use results also indicated association deviant peers family income accounted significant variance adolescent alcohol use suggesting association deviant peers family income risk factors strongly related adolescent alcohol use
synthetic azo dyes aromatic rings become important source water pollution worldwide due high color high toxicity non biodegradability study microbial fuel cell coupled constructed wetlands mfcs constructed azo dye degradation performance degradation cod removal electricity generation mfcs investigated experimental results showed cod removal rate substrate consistently higher without substrate removal rates respectively removal efficiencies different hydraulic retention time hrt without substrate highest detected power density external resistance omega uvvis absorption spectra analyze indicated degradation reactive brilliant red first occurred conjugation system later naphthalene rings benzene rings best degradation effect achieved additional substrate longer hrt however extension hrt may affect internal resistance contrary
objective investigate predictive validity fear avoidance beliefs assessed work subscale fabq fear avoidance beliefs questionnaire sample patients work related musculoskeletal disorder identify two fabq cut points identified participants high low risk non return work following interdisciplinary rehabilitation program methods retrospective analysis patient data collected conjunction victorian workcover authority sprains strains program sequential logistic regression analysis used construct model prediction baseline variables age disability using pain disability index gender fabq scores receiver operator characteristic roc curves used identify fabq cut points best predicted return work outcome results age initial fabq scores significantly improved predictive capabilities model gender disability model explained variability rtw outcome roc curves showed maximum sensitivity score identified optimum specificity conclusion individuals low fabq scores likely return work however high scores necessarily poor outcome study supports limited utility fabq score screening risk poor return work outcome patients work related musculoskeletal disorder
component based approaches prevalent software development robotic applications due reusability productivity article present embedded modular software framework networked robotic system emsbot targeting resource constrained devices microcontroller based robots emsbot primarily built upon cos iii real time support however operating system abstraction layer makes available various operating systems employs unified port based communication mechanism achieve message passing hiding heterogeneous distributed environment applications also endows framework fault tolerant capabilities describe design core features emsbot framework article implementation experimental evaluation show availability small footprint size effectiveness independence
present fully automated multi sperm tracking algorithm demonstrated capability detect track simultaneously hundreds sperm cells recorded videos accurately measuring motility parameters time minimal operator intervention algorithms kind may help associating dynamic swimming parameters human sperm cells fertility fertilization rates specifically offer image processing method based radar tracking algorithms detects tracks automatically swimming paths human sperm cells timelapse microscopy image sequences kind analyzed fertility clinics adapting well known joint probabilistic data association filter jpdaf automatically tracked hundreds human sperm simultaneously measured dynamic swimming parameters time unlike existing casa instruments algorithm capability track sperm swimming close proximity apparent cell cell collisions collecting continuously parameters sperm tracked without sample dilution currently impossible using standard casa systems provides opportunity compare data standard fertility rates use algorithm thus potential free clinician rely elaborate motility measurements obtained manually technicians speed semen processing provide medical practitioners researchers useful data currently available
field data analysis clustering powerful technique groups data different subsets using distance function data belonging subset similar nature offer heterogeneity data reside subsets clustering proved potentiality various fields bioinformatics pattern recognition image processing many paper two step artificial bee colony abc algorithm proposed efficient data clustering two step abc algorithm initial positions food sources identified using means algorithm instead random initialization along discover promising search areas improved solution search equation based social behavior pso applied onlooker bee phase abc algorithm abandoned food source location found using hooke jeeves based direct search method five benchmark two artificial datasets applied validate proposed modifications abc algorithm results study compared well known clustering algorithms experimental statistical analyses show improvements abc algorithm advantage conventional abc algorithm solving clustering problems
many sinusoidal components different power system frequency instantaneous power occur three phase induction motors faults unbalanced conditions amplitude frequency components give idea faults level theoretical analysis indicates side band components changes slip around twice power system frequency occur broken rotor bars faults new detection algorithm introduced based power spectral density changes frequency band three phase instantaneous power experimental results demonstrated new algorithm detects faults reliable effective methods
speed accuracy important factors dealing time constraint events disaster risk crisis management support object based image analysis time consuming task extracting information large images segmentation algorithms use pixel grid initial object representation would natural efficient work perceptually meaningful entities derived pixels using low level grouping process superpixels firstly tested new workflow image segmentation remote sensing data starting multiresolution segmentation mrs using esp tool superpixel level aiming reducing amount time needed automatically partition relatively large datasets high resolution remote sensing data secondly examined whether random forest classification based oversegmentation produced simple linear iterative clustering slic superpixel algorithm performs similarly reference traditional object based classification regarding accuracy tests applied quickbird worldview data different extents scene content complexities number bands assess computational time classification accuracy affected factors proposed segmentation approach compared traditional one starting mrs pixel level regarding geometric accuracy objects computational time computational time reduced cases biggest improvement min min worldview scene eight bands extent million pixels geometric accuracy kept similar slightly better slic superpixel based classification similar better overall accuracy values compared mrs based classification results obtained fast manner avoiding parameterization mrs two approaches potential enhance automation big remote sensing data analysis processing especially time important constraint
backgroundsleep disturbance frequently comorbid depression sleep complaints common residual symptoms treatment among adolescents depression present analyses investigated effect sleep disturbance depressed adolescents treated interpersonal psychotherapy adolescents ipt versus treatment usual tau school based mental health clinics methodsixty three adolescents participated randomized clinical trial ipt versus tau adolescent depression participants diagnosed dsm depressive disorder assessed symptoms depression interpersonal functioning sleep disturbance measures assessed baseline session treatment session postacute treatment follow hierarchical linear modeling used model change depression interpersonal functioning sleep disturbance resultsongoing sleep disturbance significantly associated worse depression scores rated clinician self report well worse interpersonal functioning across course treatment treatment condition predict change sleep disturbance conclusionsfor patients study sleep disturbance predictor depression interpersonal functioning depressed adolescents sleep disturbance predicted depression interpersonal stress across treatments led slower improvement depression interpersonal functioning data suggest sleep disturbance target future treatment development research among depressed adolescents
propose improved fault detection scheme based residual signals extracted line system models identified high dimensional measurement data recorded multi sensor networks system models designed coverage approach comprise linear non linear approximation functions representing interrelations dependencies among measurement variables residuals obtained comparing observed versus predicted values predictions achieved system models normalized subject uncertainty models supervised incrementally adaptive statistical tolerance band upon violation tolerance band fault alarm triggered improved methods comes two main novelty aspects development enhanced optimization scheme fuzzy systems training builds upon sparsefis sparse fuzzy inference systems approach enhances embedding genetic operators escaping local minima hybrid memetic sparse fuzzy modeling approach termed gensparsefis design application adaptive filters residual signals time sliding window based incremental decremental manner smoothen signals reduce false positive rates gives freedom tighten tolerance band thus increase fault detection rates holding level false positives results section verify increase statistically significant case adaptive filters applying proposed concepts onto four real world scenarios three different ones rolling mills one engine test benches hybridization sparse fuzzy inference systems genetic algorithms led generation high quality models turn used process residual generators new hybrid sparse memetic modeling approach also achieved fuzzy systems leading higher fault detection rates scenarios elsevier rights reserved
purpose study evaluate effects home based exercise program anxiety levels metabolic functions patients anxiety disorders taiwan purposive sampling used recruit participants randomized experimental study participants asked complete pretest month exercise program posttest week follow test months exercise program study measures included four self report scales biophysical assessments collect assess personal data lifestyle behaviors anxiety levels metabolic control functions study participants completed posttest month follow test including experimental group control group participants experimental group showed significant improvements body mass index high density lipoprotein cholesterol levels level moderate exercise program relative control group analyzed generalized estimating equations mixed model repeated measures state trait anxiety levels also significantly improved pretest follow test experimental group finally prevalence metabolic syndrome declined participants experimental group exercise program produced positive effects metabolic indicators anxiety levels taiwanese adults anxiety disorders health providers consider using similar exercise programs help improve mental physical health patients anxiety disorders communities
introductionin clinical practice research patient centred outcomes often utilised help improve communication patients clinicians help manage expectations treatment however many goals generic adequately capture details day day life bother patients hope improve therapy study aimed understand goals patients overactive bladder symptoms taking part clinical trial assess goal achievement methodsthis qualitative analysis patients goals recorded using self assessment goal achievement saga questionnaire study assessing flexible dose fesoterodine adults safina trial free text patient goals completed baseline assessment achievement performed end treatment grounded theory used develop themes sub themes resultsthree hundred thirty one patients completed trial open ended goals set six themes emerged data including oab luts finishing task hand multiple subthemes noted conclusionsby assessing understanding important patient may help tailor patient care treatment improve patient satisfaction
main objective paper present academic example controller applied teach position control design motor automatically adjust potentiometer adjustment focused solve maximum power transfer objective linear electrical circuit design involves use extremum seeking algorithm support proposal numerical simulations mathematical modelling main problem statement programmed ifac international federation automatic control hosting elsevier ltd rights reserved
high fat diets hfd impair hippocampal dependent learning memory produce important changes synaptic transmission enhancing glutamate uptake decreasing synaptic efficacy inhibiting plasticity mechanisms methyl aspartate mediated long term depression ltd within hippocampus adolescent animals seem particularly susceptible detrimental effect hfd dietary treatments carried weaning early adulthood much efficient terms hippocampal damage carried adult period palmitic acid abundant saturated fatty acid hfd effect hippocampal function needs studied however glycogen synthase kinase gsk pleiotropic enzyme highly expressed central nervous system modulates hippocampal long term potentiation ltp ltd implicated neurological disorders including alzheimer disease study characterized mice hippocampus effect hfd intervention vitro palmitic acid well possible involvement gsk mentioned plasticity mechanisms results show hfd palmitic acid inhibit ltp hippocampal slices whereas effect ltd observed moreover tideglusib atp noncompetitive inhibitor gsk induced hippocampal ltp partially reversed impairment ltp induced palmitic acid
background diagnostic construct mild neurocognitive disorders mncds substantially congruent previously proposed criteria mild cognitive impairment mci mncd mci associated neuropsychiatric symptoms nps previous studies examined prevalence nps amnestic non amnestic mci subtypes however studies exist etiological types mncd aimed estimate prevalence nps patients mncd due alzheimer disease mncd subcortical vascular mncd scvmncd determine whether nps would expand mncd phenotypes methods sample comprised patients mncd patients scvmncd cognitively normal elderly persons cnep diagnosis mncd made according dsm criteria possible mncd scvmncd patients fulfilled dsm criteria probable vascular mncd diagnostic criteria subcortical vascular mci according frisoni prevalence nps based neuropsychiatric inventory statistical analyses included parametric non parametric tests multivariate regression spearman correlation coefficient results cnep mncd scvmncd patients one nps prevalence nps mncd groups significantly higher cnep prevalent nps significant differential diagnostic value separating mncd scvmncd well mncd cnep anxiety irritability mncd depression scvmncd mncd groups observed significant correlations distinguishing nps differential cognitive disturbances amnestic syndrome mncd executive dysfunction scvmncd conclusion nps occur majority persons mncd scvmncd anxiety irrtability prevelant nps mncd well depression scvmncd ammestic anxious irritable syndrome main phenotype mncd hand dysexecutive depressive syndrome considered prevelant clinical manifestation scvmncd obtained data may used clinical differentiation mncd scvmncd patients
men batter often affected cognitive distortions related gender roles legitimization violence valid way solve conflicts objectives research analyze psychometric properties inventory distorted thoughts women use violence revised ipdmuv delete non updated items compare predictive ability revised version ipdmuv measures nomological network sample consisted men batterer men men normative population mean age years results showed acceptable fit indices unidimensional structure ipdmuv new version items alpha higher original version items score ipdmuv showed statistically significant correlations self reports measure social desirability ambivalent sexism analyzing cutoff points differentiate batterer men normative group ipdmuv higher discriminative ability compared ipdmuv hostile benevolent sexism dimensions conclude instrument adequate psychometric properties detect cognitive biases violent men partner presented instrument useful clinical purposes
master builders south africa mbsa reviewing elements national audit system author approached assist respect review terms research identify focus audit system although audits focus physical aspects construction concern much focus administration furthermore anecdotal evidence findings audits indicates focus risk management hazard identification risk assessment regional competition award winners surveyed using self administered questionnaire delivered per mail salient findings include cost quality time marginally important respondents organisations hazard identification risk assessment hira risk management critical worker participation education training construction management competencies supervision management construction management competencies important predictors performance manifests physical state aspects interventions stakeholders contributed respondents organisations achieving competition award major opposed minor extent therefore multi content cocktail required optimise performance emphasis placed hira assessment risk management auditing focus predictors performance practitioners hazard identification risk assessment interventions contribute healthy culture result healthy climate management commitment supervision worker participation published elsevier ltd
purpose objective study determine incidence injuries playing hours severity days absence cause match injuries women rugby methods performed prospective epidemiological study injury elite national female rugby players nonelite elite teams nonelite elite applying methodology injury definitions compliant international consensus statement rugby research injuries occurred usa rugby sanctioned tournament series usa rugby local area territorial union national star sevens series usa sevens invitational collegiate rugby championships results one hundred twenty time loss injuries encountered elite injury rate injuries injury rates nonelite national level elite candidates mean days missed found elite level players per injury whereas nonelite acute injuries significant resulting immediate removal pitch main mechanism injury occurred tackling players common type injury seen ligament sprains involving lower extremity common body parts injured knee head face conclusions time loss injuries occurred frequency women rugby tournaments overall injury rates women lower international elite men women rugby head neck area female players injured greater rates international male rugby injury prevention women rugby must focus injuries knee head neck understanding risk factors allow safe return play decisions formulate injury prevention protocols
gaussian process regression popular statistical kernel method learning relationship hidden data however extensive calculation kernel matrix hinders applications many computer vision tasks super resolution active sampling using active learning extract small informative subset large training set overcome bottleneck regression based still room improving quality well efficiency paper target nearly real time based termed spgpr integrating active sampling traditional sparse proposed framework based statistics model projection vector approximately sparse specific first train full model based informative subset obtained active sampling original training dataset propose employ sparse approximate full model seeking sparse projection vector significantly accelerate prediction efficiency getting higher reconstruction quality proposed method fundamentally coarse fine extensive experimental results indicate proposed method superior state art competitors promising real time application
measurement total thyroxine first testing step work thyroid disease small animals evaluated enzyme linked fluorescent assay elfa house method measure cats dogs compared concentration sera cats dogs measured elfa enzyme immunoassay eia assess concordance methods bias elfa cats dogs using bland altman plots limits agreement cats dogs imprecision calculated methods intra interassay coefficients variation cvs elfa feline sera eia respectively intra interassay cvs elfa eia canine sera reference intervals elfa method established nmol cats nmol dogs accuracy eia elfa scored assessing measured value would identify expected range low normal elevated patients based history clinical presentation diagnostic means response therapy possible cats dogs methods yielded acceptable results eia accurate compared elfa percentage true positives cats dogs eia elfa
paper briefly describes visualization method otrokovice municipality nineteen thirties rapid growth town began beginning century otrokovice around inhabitants many building plans cadastral maps historical photographs preserved period reason rendering set years created collected information chronologically sorted basis visualization otrokovice town center created begin terrain model otrokovice created based altitude values published internet buildings accessories separately modeled standard polygonal representation used textured mapping technique complex scene individual models accessories created visualization output performed rendered images animations years
paper highlights digital control problems issues controller design suggests solutions resolve purpose digital controller designed basis digital redesign emulation technique applied buck converter working continuous conduction mode nonlinearities due adc dac quantizers loop delay etc introduced control loop adverse effects performance interrogated nonlinearities suppressed retuning digital controller order controller may increase require resources implementation quantizers nonlinearities add quantization noise loop may cause offsets limit cycle oscillations lcos overall phase margin gets reduced due delay thus keeping bandwidth limited leading system towards instability well tuned loop remains asymptotically stable nonlinearities neglected matlab simulink environment used address issues
simple database storage configuration includes block device filesystem advanced multi disk database storage configuration also disk manager required article presents multi disk storage configuration impact relational database performance research results include various local multi disk storage space configuration scenarios database cluster modern database management systems popular disk managers like software raid standard thin provisioned logical volume equipped disk allocation policy research conclusions facilitate local storage space configuration efficient transaction processing relational databases
performance geosynthetic clay liners gcls arsenic rich gold mine tailings investigated construction test cover comprised three gcl products placed tailings abandoned gold mine nova scotia canada parallel research performance three commercially available gcls assessed based series laboratory column experiments three needle punched gcls tested one untreated wyoming bentonite woven carrier geotextile second polymer enhanced wyoming bentonite scrim reinforced nonwoven carrier geotextile third polymer enhanced wyoming bentonite woven carrier geotextile coated thin polypropylene geofilm years exposure field laboratory bentonite structure exhumed gcls appeared well hydrated visible cracks provided cover soil thickness gcl untreated bentonite exhibited highest reduction exchangeable sodium percentage esp decreased field laboratory swell index decreased field laboratory tests despite reduction swelling capacity maximum measured hydraulic conductivity gcl still considered low gcls polymer enhanced bentonite experienced less cation exchange esp field laboratory gcl untreated bentonite values gcl polymer enhanced bentonite non coated carrier geotextile field laboratory lower measured gcl untreated bentonite lowest measured values gcl polymer enhanced bentonite geofilm coating carrier geotextile three gcls prevented migration arsenic overlying cover soil even gcl resting directly tailings without foundation layer
background prospective memory essential productive independent living necessary compliance prescribed health behaviors parkinson disease cause deficits associated activity limitations reduced quality life forming implementation intentions iis encoding strategy may improve population objective determine effect iis performance methods laboratory based randomized controlled trial participants mild moderate without dementia performed computerized test virtual week standard instructions one week later randomly allocated perform using either iis rehearsal encoding strategy results performance better use strategies relative standard instructions effect larger tasks event based compared time based cues addition iis resulted larger effect nonrepeated tasks conclusions strategies support full encoding cues actions improve performance among people particularly tasks cues readily available environment iis may effective nonrepeated tasks finding warrants verification future work address transfer strategy use laboratory everyday life targeted strategies manage impairment could improve function quality life significantly affect clinical care people
quality life often relatively lowered families children additional needs may particularly case additional needs accompanied autism spectrum disorder asd explore effects diagnostic status specifically comparing families children asd diagnosis others additional needs signs asd additional needs signs asd diagnosis mothers children additional needs completed standardised questionnaires quality life stress service provision child behaviour presence severity asd traits addition group mothers typically developing young people completed standardised questionnaires individual family quality life behaviour son daughter mothers typically developing young people significantly higher individual family quality life scores three groups increased severity asd associated increased maternal stress turn associated decreased family maternal quality life group reporting lowest quality life highest stress mothers individuals signs asd diagnosis pattern seem explained lack access services rates intellectual disability challenging behaviour sub group finding poor quality life high stress apparent sub group mothers children signs asd diagnosis asd suggests interesting topic investigation whether receipt diagnosis positively influence quality life levels maternal stress
accreditation bodies engineering education around world advocating implementation outcome based education order achieve effectively engineering educators increasingly adopting student centered modes learning one mode problem based learning pbl paper experience implementation micro level pbl described one topic course electronic materials undergraduate programme materials engineering taught using pbl end course students feedback recorded gauge success otherwise learning method general student found enthuiastic learning pbl lectures appreciated pbl opportunity play role professional engineer apply acquired kowledge solve particular problem student feedback reveals pbl effective achieving programme outcomes pos easy achieve lectures related lifelong learning team work iii professional ethical responsibility economic social environmental impact etc thus pbl complement lectures successfully implementing outcome based education implementation pbl micro level one topic course found fairly easy require extra resources since converting whole undergraduate programme pbl formidable venture believed pbl adopted limited number topics major courses programme tangible benefits
voltage regulation fluctuations power distribution systems represents important matter electricity customers utilities distributed energy resources proven provide solutions satisfying demand also providing voltage control support electrical network reinforced coordination control actions distributed generation long designed optimal way order improve network voltage performance distributed control strategy based state based potential games proposed work control strategy applied test system illustrating benefits viability proposed approach
thiamine vitamin essential health living organisms deficiency long associated diseases animals fish birds alligators domesticated ruminant mammals thiamine also implicated several human diseases including alzheimer diabetes dementia depression notably wernicke korsakoff syndrome beriberi disease yet highly sensitive specific detection thiamine remains analytical challenge levels thiamine need detected environmental human samples respectively various phosphorylated variants need discriminated rapid site detection would highly desirable furthermore appropriate sample preparation mandatory owing complexity relevant sample matrices including fish tissues ocean water body fluids review two objectives first provides thorough overview analytical techniques published thiamine detection last years second describes principles analytical approaches based biorecognition may open new avenues rapid high throughput thiamine analysis notably periplasmic binding proteins ribozymes aptamers particular interest function bioaffinity recognition elements fill important assay technology gap owing unavailability thiamine specific commercial antibodies finally authors provide brief evaluations key outcomes major assay concepts suggest innovative techniques could help develop sensitive specific thiamine analytical test systems
mutations calreticulin calr gene found majority janus kinase negative myeloproliferative neoplasms mpn thus far exclusively reported acquired somatic mutations assessed mutational status exon calr gene blood samples submitted centre identified subjects harbouring distinctive calr mutations allelic frequency involving indels occurring multiples buccal cell samples obtained patients confirmed germline nature mutations importantly germline mutations diagnostic mpn thus report first time identification confirmation germline mutations calr distinct somatic mutations define classical mpn finding non standard calr mutation allelic frequency raise suspicion possibility germline calr mutation cases investigated
thought uniquely human prosocial behavior observed number species including vampire bats engage costly food sharing another social chiropteran jamaican fruit bats artibeus jamaicensis observed engage cooperative mate guarding thus might expected display prosocial behavior well however frugivory hematophagy diets may impose different selection pressures prosocial preferences given prosocial preferences may depend upon cognitive abilities selected different ecological constraints thus assessed whether jamaican fruit bats would assist conspecific escape paradigm donor could opt release recipient enclosure test apparatus contained two compartments one equipped sensor triggered released trap door adjacent compartment sixty six exhaustive pairs bats tested bat role twice recipient present twice absent bats decreased behavior releasing trapdoor conditions time decreasing behavior slightly rapidly recipient absent condition bats release door often recipients present regardless recipient thus clear evidence prosocial behavior
active charge accumulator aca pressure converter device water hydraulic system able increase decrease pressure without using pressure regulating valve basic characteristics acas however yet sufficiently revealed study experimentally examined basic characteristics acas focus placed acas reduce pressure examination revealed piston stroke acas depends load flow rate well valve switching timing theoretically analyzed phenomena using mathematical model analytic model built taking consideration compressibility working fluid valve performance level elements made comparison analytic experimental results verify validity analysis comparison revealed pressure waveforms low pressure pressure conversion sections obtained analysis agreed obtained experiments indicating analytic model valid
fused deposition modeling filament extrusion base additive manufacturing process integrates computer aided design system material science computer numerical control extrusion process fabricate physical parts without geometrical limitations notwithstanding wide industrial diffusion one limiting aspects technology obtainable surface roughness limitation implies secondary finishing operations necessary order comply design requirements several efforts done field lack exists computer numerical control machining fused deposition modeling mesostructure anisotropic surface morphology strongly depends upon deposition angle make difficult determination cutting process parameters aim work develop methodology able unlock possibility finish fused deposition modeling parts computer numerical control machining variable cutting depth considered avoid inner defects arising eliminate initial surface morphology experimental campaign allowed determine cutting depth set function deposition angle particular virtual model offset permitted generate computer aided manufacturing machine code case study characterized functional surfaces confirmed applicability method complex geometry great reduction average roughness reliable uniformity finished surfaces obtained elsevier ltd rights reserved
construction management system provides assistance online exchange sharing various documents related projects contracts processes government agencies construction companies perform national road river construction projects system used road river construction projects approximately locations recent development various information technologies including big data gis geographic information system cloud enabled construction workers utilize information devices work plan improving construction management system suggested study applying spatial information various map based information services could provided construction workers suggested plan expected provide workers visual construction status including cost integrating construction information spatial information reduce onsite work hours efforts providing customized functions user
introduction prostate cancer pca common disease male patients particularity androgen dependent aim current study provide overview interest testosterone dosage management pca regardless stage disease patients methods systematic review literature done pubmed database searching following key words alone combination prostate cancer testosterone risk aggressiveness hormonotherapy active surveillance prognosis androgen cardiovascular risk biochemical recurrence results level plasmatic testosterone depends moment day peak end night morning test either whole testosterone level free testosterone level bioavailable testosterone bioavailable testosterone representative presence androgen tissues specialized laboratory mandatory testosterone plasmatic rate potentially useful several steps pca management localized prostate cancer cases men low testosterone levels likely aggressive disease therefore good candidates active surveillance extensive radical prostatectomy considered case young men since patients likely recur subsequently advanced prostate cancer cases testosterone level less equal guarantee appropriate castration patient undergoing androgen deprivation treatment dissociation trend psa testosterone levels starting point castration resistant period disease conclusion testosterone level bring useful information regarding profile pca ability evolve whole natural history disease elsevier masson sas rights reserved
craig interpolation valuable tool program analysis verification modern smt solvers implement interpolation procedures theories commonly used applications however many application specific theories remain unsupported limits class problems interpolation based techniques apply paper present generic framework build new interpolation procedures via reduction existing interpolation procedures consider case application specific theory formalized extension base theory additional symbols axioms technique uses finite instantiation extension axioms reduce interpolation problem theory extension one base theory identify model theoretic criterion allows detect cases technique complete discuss specific theories relevant program verification satisfy criterion particular obtain complete interpolation procedures theories arrays linked lists latter first complete interpolation procedure theory supports reasoning complex shape properties heap allocated data structures
paper presents results liquid water injection cylinder compression expansion strokes internal combustion engine ice aim achieving optimal cylinder pressure improving power output using cfd simulation employing compression stroke degrees crank angle top dead centre btdc resulted reduction compression work due reduction peak compression pressure margin decreased peak compression pressure also yielded benefit decrease nox emission margin well prevention detonation using expansion stroke top dead centre atdc revealed two stages cylinder pressure first stage involved decrease pressure heat absorption second stage involved increase pressure result increase steam volume via expansion case water addition water temperature degrees percentage decrease cylinder pressure first stage pressure increase second stage water injection helped reducing energy losses resulting transfer heat walls exhaust gases degrees atdc exhaust gas temperature decreased respectively increasing temperature degrees resulted decrease cylinder pressure first stage increase approximately second stage use compression expansion strokes resulted maximum increase cylinder pressure demonstrating potential higher power output
network security traditional sense consists following four elements secret integrity availability authenticity recent studies indicated anonymity important indicator information security recent years research shows anonymity also gradually important indicator information security rapid development communication technology internet people pay attention personal privacy result research anonymous communication system gradually increasing network openness unpredictability malicious nodes make network user privacy information vulnerable illegal theft attacker get contents file also get identity related privacy information sender receiver anonymous technology best way solve privacy protection therefore important theoretical significance application value study anonymous technology network environment however development anonymous technology network attack technology become focus research paper mainly analyzes typical active attack technology
purpose symptoms urinary irritation urgency frequency obstruction known lower urinary tract symptoms common urological practice however little known etiology pathogenesis lower urinary tract symptoms especially relative contributions genetic environmental factors development symptoms used classic twin study design examine relative contributions genetic environmental factors occurrence lower urinary tract symptoms middle aged men materials methods twins members vietnam era twin registry used mail survey collect data lower urinary tract symptoms using pss international prostate symptom score instrument twin correlations biometric modeling used determine relative genetic environmental contributions variance pss total score individual items results participants monozygotic dizygotic middle aged male twin pairs mean age years nearly sample pss greater indicating least moderate lower urinary tract symptoms heritability total pss heritability estimates ranged nocturia straining moderate heritability urinary frequency urgency conclusions genetic factors provide moderate contribution lower urinary tract symptoms middle aged men suggesting environmental factors may also contribute substantially lower urinary tract symptoms future research needed define specific genetic environmental mechanisms underlie development symptoms conditions associated lower urinary tract symptoms
current trends evolution going towards enriching environments intelligence order support humans everyday life ami systems plunged real world humans expect interact way similar one humans kind systems eliciting requirements involves several documents stakeholders mainly users first consumers system requirement analysis phase affected incomplete ambiguous imprecise information hence need find fruitful way knowledge management representation design time paper propose set abstractions used early requirements analysis ami systems development result simple time powerful set concepts guidelines providing environment knowledge representation ami systems
paper develops proposal combination standard iso guidance project management project construction management systems emphasis integration pmbok lean construction philosophy project construction management studied global point view connecting matching supplementing combining tools techniques practices afore mentioned management systems applied construction projects within framework stakeholder participation analyzed application integrated project delivery ipd target value design tvd well sequences processes inputs outputs relate time originating variants effort achievement optimum compatibility authors published elsevier ltd
web services allow middleware access relational database require data representation xml format xml views obtained relational databases accessed using xpath queries article proposes optimization model xml data processing based heuristic algorithm extract data xpath views end author uses various xpath query classes temporarily stored cache xpath views view selected cache compensation query found composed order solve xml data query experimental results reveal effectiveness heuristic method used solve queries xml documents
despite benefits smoke free legislation adult health little known impact children health examined effects tobacco control policies rate emergency department visits childhood asthma ear infections respiratory infections using outpatient visit data massachusetts new hampshire vermont used negative binomial regression models analyze effect state local smoke free legislation visits health condition controlling cigarette taxes health care reform legislation found changes overall rate visits asthma ear infections upper respiratory infections implementation state local smoke free legislation cigarette tax increases however interaction children age revealed among year olds state smoke free legislation associated reduction visits asthma adjusted incidence rate ratios airr reduction ear infections reduction upper respiratory infections found overall reduction visits lower respiratory infections implementation state smoke free legislation implementation health care reform massachusetts also associated reduction children visits ear upper respiratory infections results suggest state smoke free legislation health care reform may effective interventions improve children health reducing visits asthma ear infections respiratory infections elsevier inc rights reserved
one main challenges ambient assisted living aal reach appropriate acceptance level assistive systems well analyze monitor end user tasks feasible efficient way development evaluation aal solutions based user centered perspective help achive goals work designed methodology integrate develop analytics user centered tools assistive systems analysis software tool gathers information end users adapted psychological questionnaires naturalistic observation context aim enable deep analysis focused improving life quality elderly people caregivers
one important methods reusing treated wastewater soil aquifer treatment sat simulation sat pounds three columns diameter height filled sandy loam soil used assess removal chemical biochemical oxygen demands cod bod nitrogen phosphate total dissolved solid total coliform fecal coliform treated wastewater soil surfaces columns covered different materials one geotextile another coarse structural debris third one remained bare columns saturated treated wastewater mahdasht karaj treatment plant experiments conducted permanent saturated soil condition removal percentages geotextile soil column bod cod tss coliform fecal coliform phosphate respectively low efficiency nitrate removal columns also observed waterlogging time leads decrease pollutant removal using geotextile structural debris soil surface covers lead reduction pollutants transfer help stabilizing soil system filter
youth leadership programming become increasingly common context foster basic psychological needs promote youth development purpose qualitative study explore strategies involved fostering youth needs support within six leadership programs two leaders youth participated semi structured interviews better understand strategies used foster needs support findings revealed leaders able foster sense relatedness among youth building trusting adult youth relationships nurturing inclusive environment maximizing choice negotiating youth voice helped foster youth autonomy finally creating task oriented climate providing intentional opportunities skill building helped foster youth competence findings suggest training leaders critical understanding strategies employed help foster youth needs support leadership programming limitations future directions outlined elsevier ltd rights reserved
background suicide major public health concern barrier reducing suicide rate lack objective predictors risk present study considers whether quantitative sleep electroencephalography eeg may neurobiological correlate suicidal ideation methods participants included female mean age adults diagnosed major depressive disorder mdd item measures thoughts death suicide quick inventory depressive symptomatology qids used classify participants low suicidal ideation females mean age high suicidal ideation females mean age data obtained archival samples collected university michigan university texas southwestern medical center sleep eeg quantified using power spectral analysis focused alpha beta delta frequencies results results indicated participants high compared low suicidal ideation experienced increased fast frequency activity decreased delta activity increased alpha delta sleep adjusting age sex depression insomnia symptoms limitations limitations include exclusion imminent suicidal intent single suicidal ideation item cross sectional archival data conclusions one first studies provide preliminary support electrophysiological brain activity sleep associated increased suicidal ideation mdd may point toward central nervous system cns hyperarousal sleep neurobiological correlate suicidal ideation
regional seismic damage simulation buildings potentially reveal possible consequences important disaster mitigation decision making however simulation involving buildings region computationally intensive study computational framework using network distributed computers equipped graphics processing units gpus proposed computational framework includes two types structural fidelity models high fidelity models employed analyze complex important buildings efficient gpu based linear equation solver developed incorporated opensees open source computational platform commonly used structural earthquake engineering simulations buildings civil infrastructures handle large number computationally intensive high fidelity structural models region dynamic load balancing strategy designed distribute computational tasks among available resources moderate fidelity models used model regular building structures gpu based tool developed accelerate simulation static load balancing strategy designed distribute computational tasks among gpus demonstrate potential cost effective flexible computing paradigm regional seismic simulation computational framework applied perform seismic simulation virtual city high fidelity structural models moderate fidelity building models elsevier ltd rights reserved
paper study new stabilized method based local pressure projection solve semi linear elliptic equation proposed scheme combines nonconforming finite element pairs ncp triangle element two level method number attractive computational properties parameter free avoiding higher order derivatives edge based data structures favorable stability less support sets stability analysis error estimates done finally numerical experiments check estimates presented
purpose low volume hospital lvh payment adjustment established patient protection affordable care act aca scheduled sunset october purpose analysis estimate effect aca lvh adjustment qualifying hospitals profitability margins examine hospital market characteristics hospitals would adversely affected loss aca lvh adjustment methods data hospital cost report information system hospital market service area file nielsen claritas pop facts file used estimate difference difference regression models hospital level random effects order determine whether aca lvh adjustment improved qualifying rural hospitals profitability margins recycled predictions estimated effect losing aca lvh adjustment profitability margins bivariate analyses explored associations predicted profitability margins hospital market characteristics findings aca lvh adjustment significantly improved sole community hospitals medicare inpatient margins year received adjustment large statistically insignificant effect profitability margins rural hospitals hospitals would adversely affected loss aca lvh adjustment likely small located south high poverty markets higher proportions black uninsured individuals conclusions elimination aca lvh adjustment would differential effects subgroups hospitals located markets serving historically underserved populations would adversely affected
arthrographis kalrae occasionally described opportunistic human pathogen study investigated immune response kalrae murine experimental infection days post infection fungal load higher early phase mice presented neurological syndrome course infection gradual increase level anti kalrae igg increased levels dth days decreased ifn gamma days increase days decreased levels cytokines gamma observed brain days results suggest immune response murine kalrae infection modulates pattern response study shows first time cytokines cellular immunomodulation occur response experimental infection kalrae mice elsevier ltd rights reserved
background objective antibacterial peptides abps essential components host defense microbial infections present domains life amps incorporating unnatural amino acids uabps exhibit several advantages naturally occurring amps based factors bioavailability metabolic stability overall toxicity methods computer aided modeling vitro susceptibility test combined rationally design short uabps potent antimicrobial activity procedure peptide characterization machine learning modeling used develop statistical regression predictors employed guide molecular design structural optimization uabps number commercially available unnatural amino acids introduced results improved uabp population obtained several promising candidates successfully prepared antibacterial potencies three bacterial strains staphylococcus aureus pseudomonas aeruginosa escherichia coli measured using broth microdilution assay consequently four uabps hybrid structure property determined high potency tested strains minimum inhibitory concentration mic conclusions molecular dynamics simulations revealed designed uabps amphipathic helix solution would largely unfold spontaneously embedding artificial lipid bilayer mimics microbial membrane elsevier ireland ltd rights reserved
studies attribute markets seasonality sentiment assume seasonal affective disorder sad creates seasonal fluctuations risk aversion turn affects prices employing variance risk premium directly test seasonality risk aversion find significant seasonality explained exogenous events market realized variance returns major macroeconomic variables use number people actively suffer sad show consistent sad hypothesis sad significantly positively correlated international comparison reveals significant positive association magnitude seasonally prevalence sad
background paradigm shift medical education methodologies traditional methods spices model necessitates change teaching assessment techniques call change accepted rejected face quality research peer reviewed evidence methods present study undertaken amongst third semester mbbs students posted forensic medicine part clinical rotations two groups students instructed topic problem based learning traditional lecture based learning respectively post exposure assessments undertaken using peer reviewed validated question paper open ended questions results assessment subjected statistical analysis respect various levels cognitive domain results results showed statistically significant learning outcomes group exposed problem based learning study may done broader basis representing core area subject conclusion study brought statistically significant better assessment scores problem based learning method manifest recall also higher levels cognitive domain learning process also witnessed appreciably increased level student operation team work coupled greater problem solving skills amongst learners qualitative research assessing competence indian medical graduate fulfil legal duties medical expert witness courts law may undertaken future
background objective assess impact obstetric mode delivery particular birth caesarean section school performance adolescents using large population based cohort methods extracted data swedish medical birth register national school register included live singleton births sweden school grades reported scale scores less pass considered poor school performance mode delivery categorised unassisted vaginal delivery assisted elective emergency measured association mode delivery poor school performance using logistic regression used quantile regression assess association mode delivery school performance across distribution scores adjusted maternal age parity small large gestational age gestational age maternal country birth maternal depression non affective disorder bipolar disorder parental income time birth parental social welfare time birth also conducted sensitivity analyses investigate association results logistic regression analysis adjusted odds ratio aor assisted poor school performance compared unassisted elective emergency quantile regression assisted showed little difference scores compared unassisted point across distribution elective associated point decrease scores emergency associated point decrease scores conclusion slight association found birth school performance however effect quite small given complex nature relationship interpreted caution
study examined prosocial compensating behavior towards socially excluded ingroup outgroup members using prosocial cyberball game year old dutch adolescents results showed adolescents compensated social exclusion unknown peer virtual ball tossing game tossing ball often player compensation conditions compared fair play condition proportion tosses towards excluded player significantly differ function group status player although compensating behavior towards ingroup versus outgroup members differ underlying motivation behavior may vary empathic concern associated prosocial tosses towards ingroup member self reported bullying behavior associated less compensating behavior outgroup condition findings may practical implications programs intending change bystander behavior bullying situations foundation professionals services adolescents published elsevier ltd rights reserved
date little research examined developmental reversals false memory outside word list paradigm purpose study investigate whether knowledge familiarity types environments influenced quantity accuracy errors recalled children year olds adults using images open recall questions findings present study support predicted reversal false memories developmental variability supporting cross effect age false memories children performed better adults providing less relevant errors commission semantic based errors environments familiar adults thee findings support predicted developmental reversal false memories findings discussed within context fuzzy trace theory semantic knowledge structures implications applied eyewitness context examined elsevier inc rights reserved
objectives examined prevalence low testosterone subset men proscar long term efficacy safety study pless serum total testosterone measured baseline methods pless enrolled men benign prostatic hyperplasia bph men body mass index bmi measurements baseline patients classified baseline results pless patients baseline bmi measurements prevalence increased increasing bmi occurring normal weight patients baseline bmi conclusions observed one five pless patients baseline bmi measurements prevalence increased increasing bmi one three obese pless patients baseline measurements
imperative interrupt link arthritis regulation oxidative stress administration antioxidants suramin known anti inflammatory antineoplastic antiangiogenic activities implying possible antioxidant property study antioxidant activity suramin cell free system found higher ascorbic acid respect scavenging effect nitric oxide hypochlorous acid hydrogen peroxide radicals besides suramin found nontoxic cultured raw cells even high concentrations along marked inhibition production suramin found curb inflammation associated collagen induced arthritis cia model administration suramin significantly reduced malondialdehyde protein carbonyl content joints liver kidney spleen rats studied vivo furthermore increased antioxidant enzymes sod catalase gst gpx activities tissues restored significantly suramin treatment silico experiments using vlife mds grip docking method showed strong affinity suramin towards erythrocyte catalase followed glutathione peroxidase thus corroborating findings antioxidant enzyme assays studies clearly indicate suramin remarkable antioxidant potential ameliorate arthritis via modulation oxidative stress elsevier rights reserved
although glucosamine commonly consumed athletes effectiveness sports injuries still debate aimed investigate effects glucosamine rehabilitation outcomes anterior cruciate ligament acl reconstructed athletes glucosamine sulfate daily weeks administered half cohort male athletes half used placebo groups received rehabilitation protocol knee pain functions evaluated visual analogue scale vas international knee documentation committee ikdc lysholm scores oral administration additionally isokinetic test performed administration period scores revealed significant improvements groups weeks significant difference detected groups parameters glucosamine supplementation improve rehabilitation outcomes athletes acl reconstruction first study investigating topic studies help obtain clear evidence glucosamine efficacy acl injured acl reconstructed athletes
recently rainwater harvesting systems received increased attention due capability adapting water scarcity climate change however key obstacle implementation rainwater harvesting systems often financially feasible given difficulty determining optimal system size key premise previous studies rainwater harvesting systems constructed single construction event even though possible construct system multiple stages assumption limits managerial flexibility construction rainwater harvesting systems particularly valuable scenarios difficult forecast future rainfall patterns therefore propose multi stage system expansion strategy implementation rainwater harvesting systems using decommissioned septic tanks scenarios uncertainty rainfall real option perspective means improve financial feasibility implementing rainwater harvesting systems tested strategy evaluating proposed rainwater harvesting system midsize apartment complex jeonju south korea multi stage expansion strategy generated option value usd study help improve financial feasibility rainwater harvesting systems adding value managerial flexibility sequential expansion rwh systems new information becomes available
purpose existing studies postcoital bleeding pcb western countries date study focused various pcb related comorbidities taiwan women work aims analyze compare presence absence pcb among taiwanese women gynecological comorbidity methods study population based retrospective cohort investigation outpatients pcb index date considered total female patients pcb icd identified using nationwide outpatient sample comparison cases randomly matched study group terms gender age resutls pcb incidence rate cases taiwanese women mean age years median age years mode age years women pcb exhibited fold risk cervical dysplasia fold risk malignant neoplasm cervix young women pcb showed high risk cervical cancer common benign diseases among pcb related comorbidities cervical erosion ectropion followed vaginitis vulvovaginitis comparison pcb non pcb groups indicated several significant high risk comorbidities including cervical polyps cervical erosion leukoplakia cervix intrauterine contraceptive device cervicitis vaginitis menopause dyspareunia vulvodynia conclusions study provides evidence pcb related comorbidities manifested benign diseases lower genital tract infection cervical cancer thus healthcare providers must ensure appropriate routine screening tests counseling given women pcb
moving centralised administrative child support system one private ordering state intervene limited circumstances requires parents agree set suitable sustainable arrangements particular implications children although child perspective often overlooked article situates children active social agents exploring interactions negotiations separated parents regard money time parenting argues policies take account agentic child experiences perspectives may fail address impact policy children lives john wiley sons ltd national children bureau
objectivesto evaluate efficacy safety mirabegron compared imidafenacin treatment female patients overactive bladder methodspatients randomized receive imidafenacin twice daily mirabegron daily weeks primary efficacy end point change total overactive bladder symptom score secondary efficacy end points included change overactive bladder symptom score day micturition diary international prostate symptom score overactive bladder questionnaire safety assessments included adverse events vital signs post void residual volume patient reported incidence severity distinctive symptoms related adverse events resultsthe mirabegron group showed significantly reduced mean total overactive bladder symptom score baseline significant differences noted change total overactive bladder symptom score compared imidafenacin group significant improvements secondary efficacy end points observed regarding mean number micturitions mean number urgency episodes mean number incontinence episodes mean volume voided micturition total international prostate symptom score quality life groups significant differences groups overall incidence adverse events incidence dry mouth significantly higher imidafenacin group mirabegron group patient reported incidence severity dry mouth significantly exacerbated imidafenacin group conclusionstreatment mirabegron daily effectively relieves overactive bladder symptoms women fewer adverse events treatment antimuscarinics
argument made retrofitting suspension bridge greatest value obtained engineer considers fundamentals engineering rather simply following code fundamentals two aspects considered one thorough understanding structural behaviour also loads resistances safety factors derived aspect covers fundamentals good design opposed good analysis preparing designs constructed short occupancies tolerant problems might arise short construction period deadlines design aspect includes looking opportunities reduce maintenance improve inspection access produce benefits may desired
paper presents step step heuristic algorithm reconfiguration radial electrical distribution systems aiming power loss minimization proposed methodology based dynamic switches set approach updated due topological changes electrical network avoid premature convergence algorithm suboptimal solutions moreover proposed algorithm considers demand variation system load curves determines sequence switching operations reconfiguration process obtain feasible operation points intermediate stages process network state reconfiguration stage analyzed using conventional power flow algorithm proposed methodology applied systems literature evaluate effectiveness elsevier ltd rights reserved
aim commentary report recent views natural history subclinical hypothyroidism according different etiologies children idiopathic natural evolution often favourable high percentage cases reverting euthyroidism remaining even prolonged follow contrast risk significant deterioration thyroid status distinctly higher children hashimoto thyroiditis risk even higher cases related chromosomal abnormalities turner syndrome
massive xml data increasingly generated representation storage exchange web information twig query processing massive xml data become research focus however traditional algorithms directly implemented distributed manner existing distributed algorithms generate lot useless intermediate results execute many join operations partial results cases others require priori knowledge query pattern xml partition storage query processing impractical cases large scale data frequent incoming new queries improve efficiency scalability paper propose phase distributed algorithm dist based node distribution mechanism avoid unnecessary intermediate results furthermore propose lightweight local index rep enhanced xml partitioning approach using arbitrary partitioning strategy based rep propose improved phase distributed algorithm distrep reduce communication cost performance guarantees analyzed extensive experiments conducted verify efficiency scalability proposed algorithms distributed twig query applications
aims two part study sought define long sacral neuromodulation users overactive bladder trial new setting attributing symptoms setting subsequently evaluated patient preferences variable stimulation regimens methods initial phase prospective pilot study participants devices turned later reactivated time symptom recurrence resolution recorded phase two participants trialed four settings masked fashion random order unmasking participants chose preferred setting followed year results twelve subjects completed phase one device mean time symptom recurrence days mean time symptom regression following reactivation days combined percentile days symptoms reflect device new setting among women completing part two popular setting time unmasking cycled setting chosen participants according published estimates battery longevity participants chose energy conserving setting time unmasking mean difference estimated battery longevity chosen baseline regimens months gains diminished following year clinical changes device settings patients providers conclusions sacral neuromodulation patients allow week trial attributing symptoms new setting additional information many opt energy conserving settings regimen warrants study wiley periodicals inc
study proposes identification algorithm time delay fractional order system measurement noise via modulating function approach polynomial function adopted modulating function approach determine coefficients modulating function provided property modulating function identified fractional order equation converted algebraic equation recursive least squares estimation algorithm estimation method coefficients offered supposing measurement noise output signal gauss white noise revised identification algorithm proposed compensate effect measurement noise finally two examples given verify effectiveness proposed method
facing increasingly serious water pollution chinese government changing environmental management strategy solely pollutant concentration control total maximum daily load tmdl program water quality models increasingly applied determine allowable pollutant load tmdl despite frequent use models studies focused parameter uncertainty water quality models affect allowable pollutant loads tmdl program particularly complicated high dimension water quality models uncertainty analysis models limited time consuming simulation high dimensionality nonlinearity parameter spaces study allowable pollutant load calculation platform established using environmental fluid dynamics code efdc widely applied hydrodynamic water quality model bayesian approach differential evolution adaptive metropolis dream algorithm high efficiency multi chain markov chain monte carlo mcmc method applied assess effects parameter uncertainty water quality model simulations influence allowable pollutant load calculation tmdl program miyun reservoir important surface drinking water source beijing suffers eutrophication selected case study relations pollutant loads water quality indicators obtained graphical method simulation platform ranges allowable pollutant loads obtained according results parameter uncertainty analysis total organic carbon toc total phosphorus total nitrogen wide ranges allowable pollutant loads reveal importance parameter uncertainty analysis tmdl program allowable pollutant load calculation margin safety mos determination sources uncertainty discussed ways reduce uncertainties proposed elsevier rights reserved
objective aim study evaluate use peg glycerides different hlb oleoyl macrogol glycerides labrafil caprylocaproylmacrogol glycerides labrasol compared labrafac lipophile peg free glyceride preparation nanostructured lipid carriers nlcs peg glycerides suggested perform dual function oily component peg containing substrate required producing pegylated carriers without physical chemical synthesis methods lipid nanocarriers loaded simvastatin promising anticancer drug optimization study nlc fabrication variables first conducted effect lyophilization investigated using cryoprotectants various types concentrations prepared nlcs characterized terms particle size size distribution pdi zeta potential drug entrapment vitro drug release morphology drug excipient interactions influence glyceridespeg cytotoxicity evaluated mcf breast cancer cells addition cellular uptake fluorescent blank nlcs results alteration different oil types significant impact drug release sucrose trehalose showed lowest increase pdi reconstituted lyophilized nlcs vitro cytotoxicity cellular uptake studies indicated showed highest antitumor effect mcf cancer cells loaded labrasol nlcs demonstrating high cellular uptake well conclusion study confirms applicability peg glycerides development nlcs encapsulating labrasol containing nlc could enhance antitumor effect drug
live yeast saccharomyces cerevisiae ncyc added diet weaning rabbits old analyse effects caeca ecosystem biotope bacterial community digestion health status two levels yeast feed group corresponding cfu compared control group without live yeast addition three groups young rabbits used first experiment measure digestibility caecal parameters calculate yeast survival rate digestive tract growth performance health status studied groups rabbits experiment live yeast concentration fell slightly diet pelleting log cfu degrees survival rate yeast digestive tract high increased increasing yeast supplementation live yeast addition modify total tract digestibility nutrients growth performance mortality rate age lower highest yeast level dead compared groups average structure caecal bacterial community modified yeast presence caecum bacterial diversity tended higher redox potential caecal content increased yeast addition whereas fermentation pattern caecal remain unaffected meanly elsevier rights reserved
western societies groups minority ethnic background represented formal mental health care however unknown minority ethnic victims child sexual abuse differ majority ethnic victims regarding help seeking behaviours study used multi method design investigate prevalence formal help seeking child sexual abuse influence attitudes towards gender roles sexuality help seeking among dutch minority ethnic majority ethnic victims also examined differences reasons seek help quantitative survey data help seeking patterns among child sexual abuse victims collected four qualitative focus groups conducted professionals working field child sexual abuse minority ethnic groups explore help seeking behaviour significant differences ethnicity emerged help seeking rates however respondents liberal gender attitudes likely disclose conservative respondents additionally interaction effect observed ethnicity gender attitudes indicating contrary main effect young people moroccan turkish heritage liberal gender attitudes less likely disclose abuse reasons seeking help differed among groups focus group members emphasised mistrust towards counsellors perceptions inhibit minority ethnic youth seeking help
background prior studies suggested darkness winter impacts level mental distress sleeping problems study investigated whether people living sub arctic sleeping problems mental distress winter methods cross sectional population tromso study conducted tromso north norway degrees north arctic circle study included entire birth cohorts random samples population aged years data collected continuously october end december except july persons completed questionnaires including hscl mctq results significant differences reporting current mental distress depending season significantly reported current sleeping problems winter seasons less sleeping problems found spring conclusions sub arctic population insomnia prevalent winter significant seasonal differences mental distress although people sub arctic clearly mentally negatively affected darkness winter negative impact winter mental distress adult population conclusive
definite pattern growth seminiferous tubules different post natal ages mammals present work involves recording changes seminiferous tubules cellular components seminiferous epithelium leydig cells male assam goats different micrometrical parameters seminiferous tubules found increase increase age male goats showed significant increase age months also micrometrical parameters different spermatogenic cells showed significant increase month old goats leydig cells could marked intertubular tissue right birth various micrometrical parameters leydig cells found increase advancement age male goats nuclear diameter leydig cells show definite pattern postnatal growth micrometrical measurements leydig cells denoted highest values age months
production tribological nanoscale multilayer crn nbn coatings thick sputtering hipims reported literature however high demanding applications internal combustion engine parts need thicker coatings production parts sputtering would economically restrictive due low deposition rates work nanoscale multilayer crn nbn coatings produced high deposition rate industrial size cathodic arc physical vapor deposition arc pvd chamber containing three cathodes alternate positions four thick nbn crn multilayer coatings different periodicities produced coatings characterized ray diffraction xrd transmission electron microscopy tem multilayer coating system composed alternate cubic rock salt crn nbn layers coherently strained due lattice mismatch film grew columnar morphology entire stratified structure periodicities adopted maintained throughout entire coating periodicity coating showed separate nbn crn peaks xrd patterns lower periodicity coatings one intermediate lattice spacing detected almost linear increase hardness decreasing bilayer period indicates interfacial effects dominate hardening mechanisms
objective describe history available data sphenopalatine ganglion spg neuromodulation treatment headache present background spg therapeutic target treat primary headache disorders years multiple destructive lesions also tried variable rate duration success neurostimulation spg cluster headache first described methods systematic review authors review anatomy pathophysiology spg cluster headache important clinical trials relating history spg neuromodulation reached current state approval european union pivotal registration study cluster headache results approved spg stimulation cluster headache mark february since several countries elected reimburse implantation cluster headache patients implanted worldwide conclusions success rates implanted spg neuromodulation experimental phase european randomized controlled trial open label extension trial registry patients implanted outside trial remain two thirds patients implanted responders defined able terminate least attacks least decrease attack frequency pivotal registration study underway confirm results obtain fda approval treatment cluster headache patients studies migraine also underway
introduction concept child abuse radically changed mode interaction pediatricians children also practice sanitary personnel primary care centers often first see victims maltreatment study aims illustrating results questionnaire sent family doctors pediatricians hospitals milan surrounding areas concerning child abuse among operators returned questionnaires results show scarce knowledge report judicial authority cases child abuse mainly lack basilar information concerning manner reporting concerns specific training almost half subjects recruited study admitted attended congress meeting concerning child maltreatment last three years time span one third read scientific articles concerning child abuse addition admit ever attended professional training course concerning child maltreatment study highlights scarce knowledge behalf pediatricians general practitioners regarding deal child abuse importance proper training programs
ultrarapid underpass urup tunneling method shield machine launched received ground surface level developed tunneling congested areas paper reports monitoring results full scale test conducted first urup tunneling project china investigation special attention paid tunneling phases shield machine buried super shallowly partially ground surface paper focuses tunneling induced soil movements grouting process measurement results indicated surface settlements represented commonly used gaussian function regardless cover depth load factor approach provides fair prediction volume loss contracting transverse soil displacement field identified dominating pattern although expanding displacement field observed several locations pressure measurements used identify time dependent response grouting process
objectives observational study evaluate relationship serum concentrations adalimumab disease activity patients receiving long term adalimumab treatment psoriatic arthritis methods serum adalimumab adalimumab antidrug antibodies quantified enzyme linked immunosorbent assay disease activity assessed using disease activity score joint measures serum reactive protein quantified using standard methods results total patients recruited significant inverse correlations serum adalimumab concentration serum reactive protein crp concentration number tender joints disease activity score das crp mean serum adalimumab levels significantly higher patients das crp patients das crp conclusions serum adalimumab could important tool may improve management psoriatic arthritis patients responding long term treatment
article defines new way perform intuitive geometrically faithful regressions histogram valued data leverages theory optimal transport particular definition wasserstein barycenters introduce first time notion barycentric coordinates histograms coordinates take account underlying geometry ground space histograms defined thus particularly meaningful applications graphics shapes color material modification beside abstract construction propose fast numerical optimization scheme solve backward problem finding barycentric coordinates given histogram low computational overhead respect forward problem computing barycenter scheme relies backward algorithmic differentiation sinkhorn algorithm used optimize entropic regularization wasserstein barycenters showcase illustrative set applications wasserstein coordinates various problems computer graphics shape approximation brdf acquisition color editing
context recent upsurge referral patients compromised left ventricular function cardiac surgery led increasing use inotropes achieve improvement tissue perfusion perioperative period aims objectives compare hemodynamic effects immediate postoperative outcomes levosimendan dobutamine patients moderate severe dysfunction undergoing pump coronary artery bypass grafting opcab settings design university teaching hospital randomized control study materials methods eighty patients randomly divided two groups group received levosimendan min group received dobutamine min hemodynamic data noted min obtuse marginal grafting surgery heart rate mean arterial pressure map pulmonary capillary wedge pressure pcwp cardiac index systemic vascular resistance index svri pulmonary vascular resistance index pvri left ventricular stroke work index lvswi right ventricular stroke work index rvswi mixed venous oximetry svo lactate measured statistical analysis used chi square student test results map pcwp svri pvri lower group compared group group patients showed statistically significant increase lvswi rvswi compared group comparatively group patients maintained higher svoand lower lactate levels duration ventilation intensive care unit icu hospital stay lower group conclusions levosimendan associated statistically significant increase indices contractility lvswi rvswi decrease pcwp opcab levosimendan group lower incidence atrial fibrillation shorter length icu hospital stay
primary aim descriptive correlational study determine domains health related quality life hrqol controlling demographic correlates predict depressive symptoms among seropositive african american men women active antiretroviral therapy art demographic questionnaire center epidemiological studies depression scale cesd health related quality life hrqol scale administered regression analyses resulted three models first model indicated emotional well explained variance depressive symptoms model two emotional well role limitations emotional health explained variance final best fitting model emotional well role limitations emotional health pain explained variance depressive symptoms respectively findings underscore need explore impact hrqol mental health also screen treat seropositive african american men women art depressive symptoms published elsevier inc
image enhancements lead improved performance increased accuracy feature extraction recognition identification classification hence change detection increases utility remote sensing suit environmental applications aid disaster monitoring geohazards involving large areas main aim study compare effect image enhancement applied synthetic aperture radar sar data landsat imagery landslide identification mapping methodology involved pre processing landsat imagery image registration despeckling sar data landsat imagery enhanced principal independent component analysis pca ica spectral index involving bands using false colour composite fcc components bearing geologic information sar data processed using textural edge filters computation sar incoherence enhanced spatial textural edge information sar data incorporated spectral information landsat imagery knowledge based classification methodology tested central highlands kenya characterized rugged terrain frequent rainfall induced landslides results showed sar data complemented landsat data enriched spectral information afforded fcc enhanced geologic information sar classification depicted landslides along ridges lineaments important information lacking landsat image classification success landslide identification classification attributed enhanced geologic features spectral textural roughness properties elsevier rights reserved
paper presents benefits using sic cascodes realize single phase continuous conduction mode ccm totem pole bridgeless power factor correction pfc converter switching khz exploiting excellent switching conduction performance sic cascodes compatibility gate drive synchronous rectification full bridge high peak efficiency achieved converter high line input output correct digital control full bridge gate signals inductor current spike zero crossing significantly reduced total harmonic distortion thd achieved high line near full load
background dystonia clinically genetically heterogeneous despite first line testing tool heterogeneous inherited disorders whole exome sequencing yet evaluated dystonia diagnostics set pilot study address yield whole exome sequencing early onset generalized dystonia disease subtype enriched monogenic causation methods clinical whole exome sequencing coupled bioinformatics analysis detailed phenotyping mutation carriers performed consecutive cases genetically undefined early onset generalized dystonia candidate pathogenic variants validated tested cosegregation whole exome approach complemented analyzing mutated yet unestablished causative genes another dystonia cases results whole exome sequencing detected clinically relevant mutations known dystonia related genes generalized dystonia cases among novel variants reflecting locus heterogeneity identified unique variants distributed genes gch thap tora ano adcy ano mutated recurrently three genes gch thap tora associated isolated generalized dystonia whereas ano adcy gave rise combined dystonia myoclonus phenotypes follow screening ano adcy revealed set distinct variants interest pathogenicity supported bioinformatics testing cosegregation work conclusions study identified whole exome sequencing effective strategy molecular diagnosis early onset generalized dystonia offers insights heterogeneous genetic architecture condition furthermore provides confirmatory evidence dystonia relevant role ano adcy likely associate broader spectrum dystonic expressions previously thought international parkinson movement disorder society
background myalgic encephalomyelitis chronic fatigue syndrome cfs characterized unexplained persistent fatigue commonly accompanied cognitive dysfunction sleeping disturbances orthostatic intolerance fever lymphadenopathy irritable bowel syndrome ibs extent gastrointestinal microbiome peripheral inflammation associated cfs remains unclear pursued rigorous clinical characterization fecal bacterial metagenomics plasma immune molecule analyses cfs patients healthy controls frequency matched age sex race ethnicity geographic site season sampling results topological analysis revealed associations ibs morbidity body mass index fecal bacterial composition bacterial metabolic pathways plasma immune molecules ibs morbidity strongest driving factor separation topological networks based bacterial profiles metabolic pathways predictive selection models based bacterial profiles supported findings topological analyses indicating cfs subgroups defined ibs status could distinguished control subjects high predictive accuracy bacterial taxa predictive cfs patients ibs distinct taxa associated cfs patients without ibs increased abundance unclassified alistipes decreased faecalibacterium emerged top biomarkers cfs ibs increased unclassified bacteroides abundance decreased bacteroides vulgatus top biomarkers cfs without ibs despite findings differences bacterial taxa metabolic pathways defining cfs subgroups decreased metabolic pathways associated unsaturated fatty acid biosynthesis increased atrazine degradation pathways independent ibs morbidity increased vitamin biosynthesis salvage pyrimidine ribonucleoside degradation top metabolic pathways cfs without ibs well total cfs cohort cfs subgroups symptom severity measures including pain fatigue reduced motivation correlated abundance distinct bacterial taxa metabolic pathways conclusions independent ibs cfs associated dysbiosis distinct bacterial metabolic disturbances may influence disease severity however findings indicate dysbiotic features uniquely cfs associated may masked disturbances arising high prevalence ibs morbidity cfs insights may enable accurate diagnosis lead insights inform development specific therapeutic strategies cfs subgroups
objective examined associations perceptions attitudes body weight adherence physical activity recommendation par adolescents achieve min day moderate vigorous physical activity tested whether body mass index bmi moderator relationships study design cross sectional survey methods self reported data canadian adolescents participated ontario student drug use health survey analysed results dissatisfaction body weight associated lower odds adherence par odds ratio confidence interval specifically perceived overweight obese lower odds adherence par compared think right weight trying gain weight likely adhere par compared nothing body weight bmi significant moderator association dissatisfaction body weight adherence par low bmi differences adherence par adolescents dissatisfied body weight high bmi adolescents dissatisfied body weight less likely adhere par dissatisfied weight results different males females conclusions results suggest adolescents dissatisfied body weight lower adherence par particularly overweight obese royal society public health published elsevier ltd rights reserved
mapreduce comes simplicity preparing input data programmer needs implement mapper reducer optionally combiner partitioner aspects execution handled transparently execution framework clusters ranging single node thousand nodes datasets ranging gigabytes petabytes however also means conceivable algorithm programmer wishes develop must expressed terms small number rigidly defined components must fit together specific ways may appear obvious multitude algorithms recast programming model purpose paper provide guide mapreduce algorithm design paper presents notion design pattern mapreduce instantiate arrangements components specific techniques designed handle frequently encountered situations across variety domains
symbolic method presented calculation weakly nonlinear distortion effect operational amplifiers avoid complicated symbolic generation considering transistor nonlinearities simplified analysis method adopted method identifies nonlinearity amplifier stage low order polynomial proposed symbolic method derive analytical distortion results automatically without need going lengthy signal flow graph analysis method applied sweep analysis opamp distortion respect external feedback elements optimal selection parameter value determined given frequency remarkable speedup repeated spectre simulation observed
paper presents results research conducted field confinement effects ultrathin dielectric films method choice method green functions proved powerful tool theoretical research solid state physics among many properties materials optical conductive etc method possible obtain critical values boundary parameters corresponding transitions bulk localized exciton states research valid four layered crystalline film since type ultrathin structure object research conditions occurrence one two three even four localized states found analyzed regions equal number localized states defined corresponds process reconstruction energy spectra excitons quasi nanostructures respect corresponding bulk structures
recent natural events earthquakes japan storm surge effects new york led growing interest sustainable civil engineering sustainability topics soil liquefaction green building design typically included within civil engineering programs baccalaureate graduate levels topics sustainability adapted secondary school students well addition efforts attract quality diverse students civil engineering given rise engineering camps aimed secondary school students research focuses exploration civil engineering sustainable module topics secondary school students development content well implementation two case studies sustainability module topics identified instructional content lesson objectives key concepts activities experiments pedagogical techniques proposed two modules applied bucknell engineering summer camp program targeting secondary school students module topics developed well case study results provide examples engineering educators throughout country introduce sustainable civil engineering way encourage future civil engineering students american society civil engineers
prevalence interatrial block iab high elderly particularly heart disease despite high prevalenceand association iab risk atrial fibrillation stroke cognitive declinelittle information exists prognosis older patients iab wave duration morphology associated risk developing stroke cognitive decline elderly patients structural heart disease aim interatrial block yearly events bayes registry assess impact iab risk stroke years follow series ambulatory patients age years heart disease centers included similar size groups patients group normal wave duration minutes documented form electrocardiographic recording stroke results study might significantly improve knowledge iab impact outcome elderly patients heart disease could open door use anticoagulation therapy elderly patients iab
objectives adults irritable bowel syndrome ibs bacterial gas production colonic fermentation related symptom generation intestinal transit whether gas production affects symptom generation psychosocial distress intestinal transit childhood ibs unknown methods children ages years pediatric rome iii ibs completed validated psychosocial questionnaires week daily diary capturing pain stooling characteristics stool form determined ibs subtype subjects completed hour lactulose breath test measurement total breath hydrogen methane production carmine red used determine whole intestinal transit time results total children mean age standard deviation years enrolled girls children produced hydrogen produced methane hydrogen methane production correlate either abdominal pain frequency severity psychosocial distress hydrogen methane production differ significantly ibs subtype methane production correlated positively whole intestinal transit time inversely bowel movement frequency methane production threshold ppm marker identifying ibs sensitivity specificity conclusions lactulose breath test total methane production may serve biomarker whole intestinal transit time bowel movement frequency children ibs children ibs lactulose breath test hydrogen methane production however correlate abdominal pain ibs subtype psychosocial distress
cognitive models vulnerability anxiety propose information processing biases interpretation bias play part etiology maintenance anxiety disorders however present little known role memory information processing accounts child anxiety current study investigates relationships interpretation biases memory fear responses learning new stimuli children aged years presented ambiguous information regarding novel animal fear interpretation bias memory information measured main findings trait anxiety interpretation bias significantly predicted acquired fear interpretation bias significantly mediate relationship trait anxiety acquired fear interpretation bias appeared important predictor acquired fear trait anxiety per relationship interpretation bias acquired fear mediated number negative memories mediated number positive false positive memories findings suggest information processing models child anxiety need explain role positive memory formation fear responses
introduction primary headaches high epidemiologic impact symptomatic treatment often remains problematic nonsteroidal anti inflammatory drugs nsaids frequently used modality employment efficacy differential efficacy highly variable study investigated current nsaid use episodic headache italian headache center january february methods retrospective evaluation performed patient records migraine tension type headache tth migraine plus tth results among migraine patients used nsaids past year preferences nimesulide ketoprofen ibuprofen complete efficacy significantly higher incomplete absent efficacy nsaids replaced triptans patients first visit year spontaneous significant return nsaids among tth patients nsaid users preferences nimesulide ketoprofen diclofenac significantly higher complete incomplete absent efficacy nimesulide ketoprofen replacement analgesics performed patients year return nsaids among migraine plus tth patients nsaid users preferences nimesulide ibuprofen ketoprofen significantly higher complete incomplete absent efficacy replacement analgesics performed patients year return nsaids conclusions nonsteroidal anti inflammatory drug use headache higher could hypothesized based guidelines nsaid preferences entirely coinciding international recommendations outcome suggests need greater awareness treatment options headache patients physicians
quantitative susceptibility mapping qsm technique depicts quantifies magnetic susceptibility sources mapping iron dominant susceptibility source brain many important clinical applications herein review qsm applications diagnosis medical management surgical treatment disease assist early disease diagnosis qsm identify elevated iron levels motor cortex amyotrophic lateral sclerosis patients substantia nigra parkinson disease patients globus pallidus putamen caudate huntington disease patients basal ganglia wilson disease patients additionally qsm distinguish hemorrhage calcification could prove useful tumor subclassification measure microbleeds traumatic brain injury patients guiding medical management qsm used monitor iron chelation therapy patients monitor smoldering inflammation multiple sclerosis lesions blood brain barrier bbb seals monitor active inflammation lesions bbb seals without using gadolinium monitor hematoma volume intracerebral hemorrhage qsm also guide neurosurgical treatment neurosurgeons require accurate depiction subthalamic nucleus tiny deep gray matter nucleus prior inserting deep brain stimulation electrodes brains patients qsm arguably best imaging tool depiction subthalamic nucleus finally discuss future directions including bone qsm cardiac qsm using qsm map cerebral metabolic rate oxygen copyright john wiley sons ltd
mechanics intracardiac blood flow epigenetic influence exerts heart function subjects intense research lately fetal intracardiac flows especially useful gaining insights development congenital heart diseases received due attention thus far likely technical difficulties collecting sufficient intracardiac flow data safe manner circumvent obstacles employing stic ultrasound scans quantify fetal heart motion three normal week fetuses subsequently performing computational fluid dynamics simulations left ventricles based patient specific heart movements analysis simulation results shows significant differences fetal adult ventricular blood flows arise dissimilar heart morphology ratio diastolic systolic duration ratio heart rate formations ventricular vortex rings observed wave flow simulations vortices sufficient momentum last end diastole responsible generating significant wall shear stresses myocardial endothelium well helicity systolic outflow based findings previous studies hypothesized vortex induced flow properties play important role sustaining efficiency diastolic filling systolic pumping cardiovascular flow normal fetal hearts
circuit parameters configuration important studying synergistic effects total dose set explore method combining dynamic parameter measurement spectrum analysis lead better understanding complex phenomenon paper symbolic circuit analysis used obtain relationship input output noise injection due photocurrent generation form rational function using symbolic variables complex frequency domain simulation technique able predict impact total dose level circuit parameters iii injected energy aset shapes basic mechanisms field collapse collection efficiency also predicted assessed
background intracranial hypotension secondary spontaneous spinal cerebrospinal fluid csf fistula rare condition serious sequelae early diagnosis treatment challenging case description present case year old male presented history sudden onset postural headaches associated upper thoracic back pain magnetic resonance imaging mri demonstrated thoracic extradural fluid collection slumping brain within posterior fossa patient initially managed period bed rest followed thoracic epidural blood patch symptoms recurred subsequent operative exploration found large arachnoid cyst csf egress linear split axilla right nerve root arachnoid cyst resected defect closed primarily symptoms completely resolved mri months postoperatively demonstrated normal spinal configuration resolution brain sagging conclusions spontaneous csf leaks rare cause postural headache although epidural blood patching easy safe intervention early serial imaging ascertain evolution pathology may identify cases amenable early surgical management
paper describes new model reduction procedure tailored power systems uses measurement data devise family reduced order nonlinear models retaining physical interpretability parameters equations manifold boundary approximation method mbam uses fisher information matrix calculated measurements identify least relevant parameter combination original model next numerically constructs geodesic corresponding statistical manifold originating initial parameters least relevant parameter direction manifold boundary found mbam identifies limiting approximation mathematical form model removes one parameter combination simplified model recalibrated fitting behavior original model process repeated appropriate mbam demonstrated example synchronous generator treated extensively literature implications proposed model reduction procedure large power system models illustrated bus dynamical model
curriculum integration multidisciplinary studies become key issues improving engineering education paper presents design implementation laboratory material based active collaborative learning integrates three traditionally independent courses industrial engineering curriculum manufacturing engineering ergonomics simulation utilizing experiential assembly system collaborative project incorporates team based learn approach theoretical knowledge subject areas components implemented dynamic reconfigurable environment students given opportunity contrast design working reality preliminary results project discussed along impact curriculum
article examines positions defended group black mulata women journal minerva biweekly magazine dedicated women color twilight nineteenth century cuba analysis wants confront positions racial gender claim raised authors open debate interacts gender racial ideologies brought patriarchal structure addressing turning points nationalist discourse also form part discussion attachment traditional archetypes gender roles interpretations legacy developed contemporary cuban academy
capability approach developed amartya sen criticized overly individualistic approach simultaneously framed alignment dominant social structure situate individual agency within frame social power structures examining agency empowerment gained mobile phone usage vietnamese foreign brides singapore use intersectionality perspective gender studies find facing multiple grounds discrimination dominant group women constantly negotiate intersections gender ethnicity social class leading two active strategies positive well empowerment essentialization gender aspiration mobile phone found active agent facilitating aspiration individual changes autonomy powerful decision making roles domestic social domains variety communicative practices developed capabilities hand mobiles also mediated enactment practices foreign brides essential beliefs idealized femininity traditional gender roles contrast dominant development discourse women empowerment socio cultural contexts influencing processes technological appropriation discussed perspective development particularly framing western notions gender equality within agentic framework
paper propose control architecture combines velocity sideslip angle yaw rate regulation motor temperature regulation electric vehicle four independent electric motors linear controller incorporates vehicle dynamics electric motor dynamics combining four wheel vehicle model motor degradation model found resulting controller enhances vehicle stability vehicle also extends lifetime motors regulating temperatures ifac international federation automatic control hosting elsevier ltd rights reserved
preliminary investigations circular volume conductors suggested far field potential magnitude declines progressively slower increasing radial distance current source follows cosine function angular displacement recording electrode electrical generator axis using circular volumes differing radii mathematical relationship angle radii far field potential amplitude determined previous theoretical relationships amplitude versus dipolar spacing current distance dipole generator bounded volume conducting medium verified near field far field potentials circular volumes found become constant radii greater bounded volume radius additionally adjoining volume conductor acts simply passive fluid filled electrode wick electrode circular volume containing generator intercompartmental opening circular volume exceeds circumference finding clinically supported recording similar somatosensory evoked far field potentials generated caudal foramen magnum various portions cranium whose connections torso foramen magnum neck average respectively finally circular volume conductors connected series channels less volume conductor circumference adjoining circular volumes equipotential far field potential present boundary first circular volume containing dipole generator observation supports clinical finding far field potential transmission multiple human bodies conductive contact
article focus role music therapy people advanced dementia families well considering resource family music therapist informing work information meaningful themes life person dementia provided constellation significant people around importance personal history identity explored family members influence music therapy numerous ways outside within sessions article explore ways reciprocal relationship therapeutic alliance developed family members loved one emphasis finding unique approach fits family concerned much pain encountered work requiring music therapist proceed caution sensitivity ways music therapy enables expression intimacy particularly couples also addressed clinical illustrations underpin themes article demonstrating value alliances made music therapist family members
purpose review phalangeal fractures dislocations fracture dislocations hand common injuries review current literature diagnosis treatment injuries athlete understanding anatomy relationship mechanism injury may help direct appropriate management return play remains important concern patient athlete recent findings findings recently published articles reinforce previously established treatment methods management finger phalangeal fractures dislocations fracture dislocations majority injuries treated non operatively technological advances implant designs may conceivably allow earlier rehabilitation turn expeditious return sport management phalangeal injuries elite athlete often necessitates special treatment considerations summary majority phalangeal bone joint injuries athlete treated comparable manner non athlete goals treatment restoration bone joint alignment stability order hasten return competition surgery means expedite return play high level athlete determined case case basis technological improvements surgical implants may enable accelerated postoperative recovery however knowledge published studies definitively support assumption
mucormycosis zygomycosis emerging fungal disease allogeneic hematopoietic stem cell transplant allo hsct recipients year old woman diagnosed acute myelomonocytic leukemia needing allo hsct presented pulmonary cerebral infection due rhizomucor pusillus fungal infection treated surgical treatment posaconazole delayed release tablets strategy allowed reaching high drug levels could obtained posaconazole solution author published elsevier ltd behalf international society infectious diseases open access article license
monitoring strain data provides possibilities fatigue assessment critical components real structures operational conditions paper presents case study investigation fatigue performance welded details long term monitoring strain data years collected structural health monitoring system mounted runyang suspension bridge runyang cable stayed bridge utilized study focuses two aspects effects different strain components raw strain data fatigue damage assessment necessity long term strain measurement fatigue evaluation results indicate temperature effect stress range spectrum negligible enormous low level stress cycles caused random interference would result erroneous equivalent stress ranges number cycles thus eliminated stress range spectrum depth analysis monitoring strain data three special months years respectively revealed short term data monitored days medium term data monitored months adequate enough reveal actual fatigue behaviors steel bridges would give inaccurate fatigue life prediction finally fatigue life predictions two types welded details considering traffic flow growth carried lessons learned long term monitoring expected enhance understanding fatigue performances steel bridges copyright john wiley sons ltd
paper proposes novel rotation invariant feature object recognition firstly local fourier transform features pixels described region encoded fisher vectors encoded vectors aggregated final representation ordinal pyramid pooling hierarchically partitions described region sub regions based orders pixels rotation invariants since encoded fisher vectors ordinal pyramid pooling strategy rotation invariant extracted feature rotation invariant nature two kinds rotation invariants investigated framework one radial gradient orientation radial gradient angle experiments handwritten digit recognition airplane car detection aerial images demonstrate effectiveness proposed method outperforms state art elsevier rights reserved
deployments technology across global toward efficient learning environment growing rapidly united kingdom educational system government investing million pounds primary secondary school early programming lessoning starting age five upwards ideology behind innovation make younger generation linked innovation digital industries improve pace successful education system world paper assessment driven educational programming tutoring system young students described high level overview provides abstract design main components proposed system well detailed discussion existing tutoring programming tools kids intention develop given proposed design fully functional evaluate different primary schools middle east countries one main intended aims study would offer suitable educational programming system could ease process teaching learning programming kids primary schooling
supplementing well recognised practical models project construction management based probabilistic fuzzy events may make possible transfer weight change extra orders assessment qualitative form quantitative one assessment however naturally burdened immeasurable subjective aspect elaboration probability occurrence construction project unforeseen building works requires application addition non measureable qualitative criteria measurable quantitative criteria still appear construction project implementation reimbursable engineering contracts random event described extra supplementary building work random character occurs specific likelihood lump sum contracts hand random event fuzzy character occurrence defined linear manner function affiliation set fuzzy events identical unforeseen events strive quantitative presentation criteria regarded nature qualitative intention determine relations led application fuzzy sets theory issue properties enable description unforeseen works construction projects unambiguous quantitative way
identified aox genes monocot species lemnoideae spirodela polyrhiza lemna gibba landoltia punctata pothoideae anthurium andraeanum anthurium amnicola monsteroideae epipremnum aureum subfamilies within araceae early diverging monocot family findings highlight presence aox ancient monocot ancestor also least partial loss gene occurred speciation events within several monocot orders presence aox monocot species challenges new understanding evolutionary history aox gene family angiosperms drives experimental bioinformatics efforts explore functional relevance two aox gene family members plant growth development knowledge gain field impact running strategies aox derived functional marker candidate development plant breeding elsevier gmbh rights reserved
fatty acids containing alkyl chain stearic acid fatty acid oleic acid fatty acid linoleic acid fatty acid common emulsifiers skin care products cosmetics also used skin cleansers study prepared calcium salts salts fatty acids determine effect degree unsaturation alkyl chain scanning electron microscopy images ray diffraction patterns show fatty acid salts plate shaped lamellar crystalline powder fatty acid salt amorphous powder therefore fatty acid salt exhibits lower lubrication ability fatty acid salts addition bactericidal ability staphylococcus aureus staphylococcus epidermidis propionibacterium acnes improved increasing degree unsaturation findings suggest salts unsaturated fatty acids potential applications cleansing cosmetic products
mimicry involves unconsciously imitating actions others powerful ubiquitous behavior social interactions long debate whether mimicry abnormal people autism spectrum conditions asc causes differences might wang hamilton social top response modulation storm model proposed people asc mimic unlike neurotypical participants fail modulate mimicry according social context study used established mimicry paradigm test hypothesis neurotypical participants direct gaze specifically enhanced congruent hand actions previously found asc sample direct gaze led faster reaction times congruent incongruent movements result shows mimicry intact asc socially modulated gaze predicted storm
paper aimed towards studying compiling analyzing recent advances risks current ambient technology present modern day cars progression sophisticated technologies inside cars make even comfortable entertaining place especially commutes work recent security threats distractions uncovered upsurge usage new technologies study also includes survey senses people use car technologies driving authors published elsevier
purpose qualitative secondary data analysis examine major influencers mothers hiv childbearing decisions well influencers shape conversations clinicians health care providers regarding hiv treatment prevention original study gained insight reproductive decision making mothers hiv analyzing subsample interviews original cohort participants earlier study three major themes identified follows family members health care providers influence reproductive decisions negative attitudes toward subsequent pregnancies mainly due hiv transmission birth control decisions predominately supported family members health care providers consulted
article aims investigating filtering abilities periodic structures nonlinear interconnected synchronized switch damping inductor electrical networks periodic structures without electrical networks naturally function filtering since structure response breaks pass bands stop bands structure excited external force multiple varying frequencies introduction linear electrical networks periodic structure makes stop bands structure wider structure without electrical networks however nonlinear piezoelectric electrical networks may better effect mechanical wave attenuation linear piezoelectric electrical networks terms frequency band therefore article proposes piezoelectric periodic structure nonlinear interconnected synchronized switch damping short circuit synchronized switch damping inductor electrical network transfer matrix formulation including interconnected electrical network also proposed deriving characteristics elastic wave propagation results show proposed technique permits enhancing damping abilities particular frequency bands compared electrically independent periodic cells combined structural tailoring would allow achieving high damping performance
vasopressors widely used resuscitation ventricular failure sepsis often induce pulmonary hypertension undefined mechanisms hypothesize vasopressor induced pulmonary hypertension caused increased pulmonary blood volume tested hypothesis dogs general anesthesia normal hearts model phenylephrine min transiently increased right decreased left cardiac output associated increased pulmonary blood volume pressures left atrium pulmonary capillary pulmonary artery however trans pulmonary gradient pulmonary vascular resistance remained stable changes absent decreasing blood volume right cardiac dysfunction reduce pulmonary blood volume model double ventricle bypass model phenylephrine min slightly induced pulmonary vasoconstriction vasopressin dose dependently increased pulmonary artery pressure cause pulmonary vasoconstriction normally beating hearts model pulmonary artery left atrial pressures increased left ventricle dysfunction model increased phenylephrine injection respectively conclusion vasopressors increased blood volume lung minimal pulmonary vasoconstriction thus pulmonary hypertension similar hemodynamic pattern observed left heart diseases passive due redistribution blood systemic pulmonary circulation understanding underlying mechanisms may improve clinical management patients taking vasopressors especially coexisting heart disease
beta hydroxysteroid dehydrogenase type beta hsd expressed almost exclusively testis converts delta androstene dione testosterone mutations hsdb gene causing beta hsd deficiency responsible rare recessive form disorders sex development dsd report novel cases tunisian patients beta hsd deficiency due previously reported mutations well case novel compound heterozygous mutations moreover previously reported polymorphism identified heterozygous state combination novel non coding variant also heterozygous state male patient presenting micropenis low testosterone levels identification four different mutations cohort eight patients confirms generally observed genetic heterogeneity beta hsd deficiency nevertheless analysis dna randomly selected healthy controls geographic area region sfax revealed high carrier frequency mutation approximately genotype reconstruction affected pedigree members revealed mutation carriers harbored haplotype indicating inheritance mutation common ancestor thus identification founder effect elevated carrier frequency mutation emphasize importance consider mutation diagnosis genetic counseling affected beta hsd deficiency pedigrees tunisia elsevier ltd rights reserved
people imagine criminal behavior greater detail ascribe blame criminals description crime written using imperfective verb aspect hart albarracin experiment initiative reproduce findings conducted eerland yielded lack replication eerland suggested original effect likely driven type error produced methodological aspects experiment including low sample size recent conceptual replications hart albarracin effect sherrill eerland zwaan magliano however might imply effect could contingent sample characteristics
aim calcium channel blockers widely used cardiovascular diseases besides type channels type calcium channels involved contraction human renal blood vessels hypothesized type channels involved contraction human brain mammary blood vessels methods internal mammary arteries bypass surgery patients cerebral arterioles patients brain tumours without hypertension tested myograph perfusion set pcr immunohistochemistry performed isolated blood vessels results type antagonist agatoxin iva mol type calcium blocker mibefradil mol inhibited kcl depolarization induced contraction mammary arteries hypertensive patients effect blood vessels normotensive patients omega agatoxin iva decreased contraction cerebral arterioles hypertensive patients type blocker nifedipine abolished contraction mammary arteries pcr analysis showed expression type ttype type calcium channels mammary cerebral arteries immunohistochemical labelling mammary cerebral arteries revealed presence cav endothelial smooth muscle cells cav also detected mammary arteries conclusion type present human internal mammary arteries cerebral penetrating arterioles type calcium channels involved contraction mammary arteries hypertensive patients normotensive patients furthermore cerebral arterioles type channels importance restricted hypertensive patients might lead type channels could new target hypertensive patients
objectivesto assess relationship hormone replacement therapy hrt coronary artery calcium cac designcross sectional settingestablished population based cohort reykjavik iceland participantswomen mean age completed questionnaires hrt use measurementscoronary artery calcium assessed using computed tomography outcome variable compared women history hrt never used hrt analyzed according age length use time menopause hrt initiated resultseight hundred seventy two participants used hrt current users adjustment age late life variables propensity score based midlife data hrt use observed late life significant negative associations cac history length hrt use association evident age categories hrt used longer years median cac level less observed never users lowest cac observed started hrt within years menopause prevalence coronary events comparable groups conclusiona strong association found long term hrt use low cac negative association duration hrt cac evident age groups older women
repeated exposure methamphetamine meth cause severe neurotoxicity cortical neurons present study investigated effect meth cognitive function deficits determined neuroprotective effects memantine mem memory impairment induced meth protein levels bcl cleaved caspase prefrontal cortex pfc examined exploring underlying mechanism found repeated meth administration impaired long term memory retention without affecting short term min memory retention administration mem meth training session significantly improved meth induced cognitive function meth significantly decreased expression level bcl increased expression level cleaved caspase pfc changes prevented mem pretreatment thus results demonstrated mem pretreatment reversed meth induced changes protein levels apoptotic related gene produced protective effects meth induced cognitive deficits suggesting effectiveness mem may due anti apoptotic activity elsevier rights reserved
tested social cognition abilities adolescents autism spectrum disorders asd neurotypically developed peers ntd multi faceted test battery including facial emotion categorization fec classical false belief tasks fbt complex social cognition yielded significantly lower accuracy rates fec complex tasks asd significant differences performance concerning fbt significant correlation age performance fec task complex task found asd propose dynamic fragmented fec tasks elicit deficits implicit processing facial emotion efficiently difficulties asd solving complex tasks ascribed deficits acquisition application social schemata
background chronic hepatitis virus hcv infection important cause hepatocellular carcinoma hcc epithelial mesenchymal transition emt key process associated tumor metastasis poor prognosis hcv infection hcv core nsa protein could induce emt process role nsb emt remains poorly understood methods overexpressed hcv nsb protein hepg cells huh cells infected hcvcc cadherin expression cadherin expression emt associated transcriptional factor snail determined migration invasion capabilities transfected cells evaluated using wound healing assay additionally used snail sirna interference confirm relation hcv nsb snail emt promotion results hcv nsb increased expression emt related markers promoted cell migration invasion snail knock almost completely eliminated function nsb protein emt changes reversed cell migration capacity lower level hcv nsb protein could reduce expression scribble hippo signal pathway subsequently inactivated resulting activation pik akt pathway may reason regulation snail conclusions study demonstrates hcv nsb protein induces emt progression via upregulation snail hcc may novel underlying mechanism hcv associated hcc development invasion metastasis
paper presents design modeling control novel wave energy converter wec using dielectric electro active polymer deap application deap wec attracted lot works due development renewable energy increasing human energy demand however various challenges wec using deap must overcome going realistic application firstly stretch ratio significant influence energy conversion efficiency deap exceed limitation value due mechanical electrical breakdown whereas small stretch ratio reduces energy conversion efficiency significant secondly wec controlled maximize absorbed energy therefore study employs innovative device adjust inertia floating buoy variable inertia hydraulic flywheel attached main thrust shaft control stretch ratio based change hydrodynamic behavior system proportional integral derivative pid controller designed optimize stretch ratio different regular waves consequently overall energy conversion efficiency proposed wec reach
objective goal study develop practical framework recognizing disambiguating clinical abbreviations thereby improving current clinical natural language processing nlp systems capability handle abbreviations clinical narratives methods developed open source framework clinical abbreviation recognition disambiguation card leverages previously developed methods including machine learning based approaches recognize abbreviations clinical corpus clustering based semiautomated methods generate possible senses abbreviations profile based word sense disambiguation methods clinical abbreviations applied card clinical corpora vanderbilt university medical center vumc generated comprehensive sense inventories abbreviations discharge summaries clinic visit notes furthermore developed wrapper integrates card metamap widely used general clinical nlp system results conclusion card detected distinct abbreviations discharge summaries clinic visit notes respectively two sense inventories constructed frequent abbreviations corpora using sense inventories created discharge summaries card achieved score identifying disambiguating abbreviations corpus vumc discharge summaries superior metamap apache clinical text analysis knowledge extraction system ctakes using additional external corpora also demonstrated metamap card wrapper improved metamap performance recognizing disorder entities clinical notes card framework sense inventories wrapper metamap publicly available https sbmi uth edu ccb resources abbreviation htm believe card framework valuable resource improving abbreviation identification clinical nlp systems
commercially available fluctuating temperature chambers large costly poses challenge experimental ecologists endeavouring recreate natural temperature cycles laboratory large number commercial chambers required replicated study designs prohibitively expensive purchase requires large amount space consumes great deal energy developed validated design economical programmable fluctuating temperature chambers based relatively small commercially manufactured constant temperature chamber modified customized user friendly microcontroller week trial chambers reliably reproduced real world fluctuating degrees body temperature regime individual frog near perfect fit target actual temperatures confidence interval slope day trials also reliably produced simpler daily fluctuating temperature scheme sine wave fluctuating degrees range constant temperature regimes design inexpensive simple assemble large numbers enabling genuine replication even highly complex many treatment study designs example possible simultaneously examine replicate chambers responses organisms constant regimes regimes fluctuate following means experienced populations regimes exactly mimic fluctuations measured length time particular individuals differ behaviour microhabitat use chambers thus vastly expand pool resources available manipulative experiments thermal biology ecology
objective high resolution peripheral quantitative computed tomography pqct novel imaging modality capable visualizing bone microarchitecture vivo human peripheral sites distal radius distal tibia research extended technology provide non invasive assessment bone microarchitecture human knee establishing new hardware imaging protocols data analysis design custom leg holder developed stabilize human knee centrally within second generation hrpqct field view five participants anterior cruciate ligament reconstructions knee joint imaged continuous scan axially nominal isotropic voxel size bone mineral density microarchitecture assessed within weight bearing regions medial lateral compartments knee three depths weight bearing articular bone surface including cortical trabecular bone regions results scan duration approximately min per knee produced projection data reconstructed image data image matrix slices motion scan minimized leg holder similar magnitude scan distal tibia bone mineral density microarchitectural parameters assessed volumes interest tibiofemoral joint conclusions new non invasive vivo assessment tool bone microarchitecture human knee provides opportunity gain insight normal injured surgically reconstructed human knee bone architecture cross sectional longitudinal studies crown copyright published elsevier inc rights reserved
argument based machine learning abml knowledge refinement loop offers powerful knowledge elicitation tool suitable obtaining expert knowledge difficult domains paper first use conceptualize difficult even ill defined concept distinguishing basic advanced programming style python programming language teach concept interactive learning session student computer demonstrate automatically selecting relevant examples counter examples explained student abml knowledge refinement loop provides valuable interactive teaching tool
purpose study evaluate relationship daytime activity sedentary time moderate vigorous intensity physical activity mvpa indices polysomnographically psg assessed sleep including sleep disordered breathing sdb one hundred thirty six adults female years body mass index bmi provided daily estimates time spent light moderate vigorous intensity activity days mean days prior laboratory psg daily sedentary time calculated amount time spent awake light moderate vigorous intensity activity time spent moderate vigorous intensity activity combined mvpa indices psg sleep included timing sleep midpoint duration total sleep time continuity sleep efficiency depth slow wave sleep sdb apnea hypopnea index ahi using median splits sedentary time mvpa analyses covariance examined relationship sleep following adjustment age sex race employment education bmi existing cardiovascular disease depression history mean daily wake time binary logistic regression examined odds least mild severity sdb ahi according sedentary time mvpa combination adults median sedentary time min day significantly greater ahi lower odds mild sdb compared adults low sedentary time adults high mvpa min day significantly lower ahi compared adults low mvpa examined model adults high sedentary time low mvpa significantly higher ahi higher odds mild sdb groups sleep measures related sedentary time mvpa combination sedentary time mvpa associated sdb whether reducing sedentary time leads lower sdb severity deserves future exploration
formation damage due incompatibility formation injected low salinity water decreases relative permeabilities oil brine increases residual oil saturation decreases oil recovery presence swelling clays shock effect sudden water injection results increase formation damage clay minerals may cause formation damage due swelling migration production oil gas therefore good understanding damage mechanisms clays helps prevent remedy possible damage reservoirs work effect clay swelling behavior oil recovery factor pore scale using glass micromodel studied clay coated micromodel sodium bentonite swelling clay prepared using image processing technique ultimate oil recovery factors flooding low salinity water isw high salinity water hsw estimated effect clay swelling phenomena oil recovery factor studied final residual oil saturation higher lsw used injection fluid compared hsw used fact said clay swelling somehow inhibits film flow injection fluid causes oil bypassed micromodel elsevier rights reserved
current study shows real estate prices several countries reveal significant persistent seasonality highest rates return obtained spring early summer lowest rates return obtained fall seasonality explained joint effect change number daylight hours latitude area zone consideration notably latitude affects real estate prices beyond effect change number daylight hours function latitude joint effect robust two explanations seasonality given literature matching theory bargaining power hypothesis well several macroeconomic variables effect also conforms well known seasonal affective disorder sad found studies affect people health risk attitude consequently risk perception investment decisions turn affect asset prices elsevier rights reserved
recent years deep learning attracted increasing amount attention machine learning artificial intelligence areas currently many deep learning network related architectures deep neural networks dnns convolutional neural network cnn wavelet scattering network scatnet principal component analysis network pcanet proposed effective network pcanet achieved promising performance image classification face object handwritten digit recognition pcanet handle data represented single view features paper present canonical correlation analysis network ccanet address image classification images represented two view features ccanet learns two view multistage filter banks canonical correlation analysis cca method constructs cascaded convolutional deep network incorporate filters binaryzation block wise histogram processes form final depth structure addition introduce variation ccanet dubbed randnet filter banks randomly generated extensive experiments conducted using eth yale usps databases object classification face classification handwritten digits classification respectively experimental results demonstrate ccanet algorithm effective pcanet randnet randnet elsevier inc rights reserved
goal article present role technology transit different stages mathematical modeling cycle since tecnologico monterrey began development course involves mathematical modeling perspective principal mean learning differential equations presented design specific situation related circuits electric context activities based use diverse technology based praxeological study describes types tasks related mathematical modeling cycle technology applied also former ones might propose better transit diverse domains modeling cycle conclude concluding remarks future lines research
background lat slca transport competent unit heterodimer formed glycoprotein slca catalyzes antiport neutral amino acids ile leu val cys met gln phe thus involved amino acid metabolism interestingly lat expressed many human cancers characterized increased demand amino acids therefore lat recently acknowledged novel target cancer therapy however knowledge molecular mechanism lat transport still scarce methods combined approaches bioinformatics site directed mutagenesis chemical modification transport assay proteoliposomes adopted unravel dark sides human lat structure function relationships results demonstrated residues crucial substrate recognition plays minor role targeted reagents transporter preferential dimeric structure catalyzes antiport reaction follows simultaneous random mechanism conclusions critical residues substrate binding site lat probed site freely accessible molecules substrate similarly leut regulatory properties lat general significance collected data represent solid basis deciphering molecular mechanism underlying lat function elsevier rights reserved
many women commuted shorter distances less time men research underscored pernicious effects racial ethnic segregation access transportation minority women commuting since growing income inequality bifurcation employment well paid secure jobs growing number insecure poorly paid jobs accompanied concentration jobs central suburban locations transformation women roles labor market investigate geographical implications trends analyzing commuting new york metropolitan region gender race differences commuting varied across metropolitan area regression analysis demonstrates impacts wages household composition commuting differ highly valued center benefited private public investment suburbs traditional gender roles persist deteriorating inner ring minority women still commute long times slow public transit findings highlight racial gender disparities geographical access employment within metropolitan region
world health organization widely criticised failing anticipate outbreak ebola remote forested region south eastern guinea would trigger public health emergency international concern pheic explaining failure critics pointed structural restraints united nations organisation leadership vacuum geneva among factors paper takes different approach drawing internal documents interviews key actors epidemic response argue failure better understood consequence ebola shifting medical identity triage systems managing emerging infectious disease eid risks focusing discursive non discursive practices produced ebola problem global health security argue ebola longer regarded paradigmatic eid potential biothreat much neglected tropical disease result relegate ebola fringes biosecurity concerns moment virus crossing international borders west africa triggering large urban outbreaks first time ebola fluctuating medical identity also helps explain prominence fear rumours epidemic social resistance ebola control measures contrasting delay declaring pheic rapid declaration pheics relation swine flu polio conclude missed alarms may inescapable consequence pandemic preparedness systems seek rationalise responses emergence new diseases
three dimensional finite element model developed order analyze free vibration characteristics tower cable system triple tower twin span suspension bridge construction phase right erection main cable dynamic characteristics component tower cable system isolated side span main span cables free standing towers first analyzed separately natural frequencies vibration modes isolated side span main span cables obtained finite element analysis closely matched analytical solution linear free vibration analysis verified validity finite element model local natural frequency global natural frequency defined categorize characteristics free vibration calculation results show tower cable system maintains information modal characteristics component system also contains unique modal characteristics important information dynamics characteristics system lower natural frequency range swinging motion plane motion uncoupled coupled modal information towers cables separated two groups based natural frequencies vibration main component tower cable system additional natural frequencies vibration modes obtained finite element analysis depicting dynamic interaction towers cables furthermore observed lower order modes side span cables couple higher order modes main span cables either phase phase local global modes tower cable system exhibits many new coupled mode combinations reveal useful information
paper proposes dimmable energy efficient light emitting diode led driver applications interior lighting high efficiency achieved adaptive voltage regulation minimizes power losses linear current regulator digital control mechanism employing resistive digital analog converter feeding analog feedback input converter introduced shown digital control methodology gives maximum design flexibility enhances control regulation speed stability experimental setup proposed concept verified evaluated operating input voltage led driver provides relatively wide output voltage range output current regulated steady state precision whereas pulsewidth modulation dimming frequency khz shortest time employed peak efficiency complete system achieved
improving energy efficiency buildings windows play significant role largely influence energy load although many studies energy efficient window design rigorous study missing analyzes mutual impact windows size position orientation energy load study aims address gap case study single family house aim different design scenarios created vary window size position orientation building information models bims created scenario via autodesk revit used calculation total energy load conducted autodesk green building studio first analysis stage window wall ratio wwr windows position studied assess effect energy load preliminary results stage indicate total energy load increases wwr grows windows position biggest impact load wwr using results next stage position windows different orientation studied assess energy load changes windows position orientation results show building requires lowest load windows located middle height orientations east windows positioning affects total energy load
several techniques used requirements engineering practitioners address difficult problems specifying precise requirements using inherently ambiguous natural language text ensuring consistency requirements often problems addressed building processes tools combine multiple techniques output technique becomes input next powerful techniques without problems inherent errors technique may leak subsequent step process model study process checking consistency temporal requirements assess error leakage wasted time perform analysis input factors model determine effect sources uncertainty may final accuracy consistency checking process convinced error leakage exists negatively impacts results overall consistency checking process perform second simulation assess impact analysts efforts check requirements consistency show analyst effort varies depending precision recall subprocesses number capability analysts affect effort share insights gained discuss applicability processes built piped techniques
background cross sectional study examined whether changes occur people capacity coordinate two simultaneous tasks dual task transitioning adulthood later life central executive baddeley working memory model component responsible coordination contradictory results reported regarding relationship ageing dual task performance seem related methodological issues addressed study methods nine hundred seventy two participants aged years old volunteered carry verbal digit span task followed single concurrent dual task tests first box crossing task digit recall task relation memory span finally tests simultaneously results found difference people capacity coordinate attention two tasks adulthood healthy later life including oldest age groups furthermore gender educational level related dual task performance conclusions results support normal functioning central executive old people data contrast research patients suffering different types dementia show decrease dual task performance
order study evolution mechanism forecast development direction green building market paper establishes model asymmetric evolutionary game green building market using idea evolutionary game firstly dynamic equations two strategies set using idea replicator dynamics evolution game lastly evolutionary game equilibrium model established analysis results show build green buy green build non green buy non green two evolutionary stable situations empirical analysis development green building country divided three development stages analyzing evolution characteristics stage evolution mechanism development trend green building country obtained
aimsthe purpose study evaluate lower urinary tract symptoms luts idiopathic normal pressure hydrocephalus inph methodspatients new onset inph prospectively evaluated luts via detailed history physical administration questionnaires international consultation incontinence assess incontinence iciq overactive bladder iciq oab quality life iciq lutqol well american urological association symptom score bother scale patients moderate severe luts offered urodynamic testing sub analysis performed based gender medical comorbidities age resultsfifty five consecutive patients inph completed initial evaluation surveys total urinary incontinence score mild moderate scale experiencing leakage reporting urge incontinence common oab symptom nocturia scale urge incontinence bothersome scale quality life impact moderate scale american urological association symptom score bother scale scale urodynamics testing revealed detrusor overactivity mean bladder capacity several differences identified based gender medical comorbidities age conclusionspatients inph present mild moderate incontinence nocturia common symptom urge incontinence bothersome patients detrusor overactivity younger patients experienced greater bother related luts knowledge prospective evaluation urinary symptoms patients new onset inph
investigated paper variable coefficient higher order nonlinear schrodinger equation describe propagation subpicosecond femtosecond optical pulse inhomogeneous optical fiber set painleve integrable coefficient constraints equation transformed bilinear forms single two anti dark soliton solutions constructed via hirota method based solutions graphically discuss features anti dark solitons well interaction inhomogeneous optical fibers shown results backgrounds anti dark solitons related gain loss coefficients third order dispersion coefficients directly influence propagation trajectories anti dark solitons provide possible way manage solitons inhomogeneous fiber hand overtaking interaction two anti dark solitons obtained seen elastic frequency shift parameter gamma almost effect solitons
paper presents power system harmonic elimination using mixed adaptive linear neural network variable step size leaky least mean square adaline vssllms control algorithm based active power filter apf weight vector adaline along variable step size parameter leakage coefficient vssllms algorithm automatically adjusted eliminate harmonics distorted load current iteration vssllms algorithm selects new rate convergence searching runs computations adopted shunt hybrid apf shapf consists apf series tuned passive filter connected phase performance proposed adaline vssllms control algorithm employed shapf analyzed simulation matlab simulink environment experimental results real time prototype validate efficacy proposed control algorithm
present research examined effects pre encoding pre recall induced mood episodic memory hypothesized happy angry mood prior encoding increasing left hemisphere activity tandem fearful mood prior recall increasing right hemisphere activity would associated superior episodic memory also hypothesized tympanic membrane measures tmt indicative hemispheric activity would change function induced mood although subjectively experienced mood induction successful pre encoding pre recall mood alter memory altered tmt pre encoding fear pre recall angry mood induction conditions interestingly baseline absolute difference left right tmt measure differential hemispheric activity regardless direction activity significantly positively related number total words written number correctly recalled words corrected recall score tmt measure pre encoding regardless specific mood significantly negatively related false recall results discussed terms hera model episodic memory nature interhemispheric interaction involved episodic recall elsevier inc rights reserved
ligament injury common sport injury athletic sports training progress development suture technique provides good guarantee treatment tear rupture tendon ligament tissue units use absorbable suture materials prevent partly risk treatment induced absorbable suture materials therefore absorbable suture materials generally favored doctors patients absorbable sutures degraded soluble product body thereby reducing patients second operation pain minimize patient suture scar formation get favor doctors patients different materials absorbable sutures appeared meet people needs extend
background postdecompressive craniotomy defect management following failed prior cranioplastyis challenging authors describe staged technique utilizing free muscle transfer tissue expansion custom polyetheretherketone peek implants management previously failed cranioplasty sites patients complicating local factors methods consecutive patients previously failed cranioplasties following large decompressive craniectomies underwent reconstruction skull soft tissue defects staged free latissimus muscle transfer tissue expansion placement custom computer aided design modeling peek implants temporalis plus modification minimize temporal hollowing implants placed vascularized pocket third stage elevating plane previously transferred latissimus superficial fascia left skin muscle left dura bone patients evaluated postoperatively cranioplasty durability aesthetic outcome complications results six patients average previously failed cranioplasties underwent staged technique average age years average defect size average time procedure series completion months flap failures one patient early postoperative incisional dehiscence following peek implant placement managed immediate scalp flap readvancement month average follow cranioplasty failures three patients underwent subsequent refining outpatient procedures patients achieved complete coverage craniectomy defect site hear bearing skin acceptable head shape normalized head contour conclusions described technique resulted aesthetic durable craniectomy defect reconstruction retention native hear bearing scalp skin challenging patient population
informal seed saving farmer farmer seed exchange dictated local rules practices turn influence distribution management crop biodiversity systems essential components livelihoods small holder farmers kenya situ conservation intraspecific interspecific diversity using mixed methods approach combining interviews focus groups household survey identify distribution crop varieties tharaka kenya shaped human migrations transported seeds gender roles restricted travel utilization local indigenous varieties early migrations results suggest migrations first tharaka people mbwa years ago influenced concentration local indigenous varieties areas first settlement today subsequent smaller migrations dictated men within tharaka particularly northern areas originally limited distribution crops pearl millet pennisetum glaucum dependent women seed selection processing study offers specific case consideration human migration gender roles currently historically influenced distribution crop biodiversity thus farmer access specific types varieties within single region ethnic group
hepatocellular carcinoma hcc also called malignant hepatoma one deadliest cancers due complexities reoccurrence surgical resection metastasis heterogeneity incidence mortality hcc increasing western countries expected rise consequence obesity epidemic multiple factors trigger initiation progression hcc including chronic alcohol consumption viral hepatitis infection metabolic disorders age although sorafenib fda approved drug treatment hcc numerous treatment modalities transcatheter arterial chemoembolization transarterial chemoembolization tace radiotherapy locoregional therapy chemotherapy tested clinics polymeric nanoparticles liposomes micelles carrying small molecules proteins peptides nucleic acids attracted great attention treatment various cancers including hcc herein discuss pathogenesis hcc relation various recent treatment methodologies using nanodelivery monoclonal antibodies mabs small molecules mirnas peptides synopsis recent clinical trials mabs peptide drugs presented broad overview pathogenesis disease treatment efficacy elsevier inc rights reserved
paper original method construction special orthogonal transform data compression proposed method based direct modification multiplication coefficients signal flow graph fast cooley tukey algorithm transform matrix constructed according reference vector calculated processed data using transform compression method multi dimensional data proposed method proved effective nuclear physics data results obtained using derived transform classical transforms compared
role tumor microenvironment leukemias lymphomas well established yet intricacies malignant cells regulate influence non malignant counterparts remain elusive example chronic lymphocytic leukemia cll expansion malignant cells yet non malignant cells play large role disease presentation etiology herein review dynamic tumor cell lymphoid repertoire interactions found two non hodgkin lymphoma subtypes cll angioimmunoblastic cell lymphoma aim highlight pivot work done murine models recapitulate diseases explore insights gained studying immuno oncological regulation non malignant lymphoid counterparts
paper presents results study utilization copy voltage controlled current follower differential input transconductance amplifier vccfdita active element single purpose filtering structure active element three voltage controlled parameters intrinsic resistance current input voltage gain transconductance output section useful design oscillators signal generators frequency filters one active element paper important parameters possible behavioural model vccfdita shown particular solution controllable band pass filter presented theoretical calculated simulated moreover also measured results mutually compared
purpose purpose paper compare performance levels small scale local government contractors sslgcs northern part nigeria international practice previous studies focused attention primarily benchmarking performance contractors mostly conceptual rather empirical findings continuous pose challenge sustainable development construction industry particularly developing countries like nigeria therefore need identify assess compare performance practice levels small scale contractors design methodology approach performance contractor evaluated using five point likert scale used obtaining mean performance levels respect three classes performance practices questionnaire survey administered major parties industry clients contractors consultants selected using proportionate stratified random sampling technique contractors performance compared using anova post hoc findings results indicated sslgcs nigeria average performers effects differences among various contractors levels performance international practice research limitations implications study limited sslgcs northern part nigeria practical implications study provided criteria evaluation sslgcs performance nigeria developing countries faced similar problems social implications study created bases self evaluation competition among small scale contractors nigeria enhancement productivity particularly rural areas general national development originality value study emanated governmental reports past researches area performance management persistence poor performance small scale contractors construction industry
hybrid safety injection tank sit enhance capability advanced power reactor plus apr station black sbo accompanied severe accident may useful alternative electric motor operations strategy sit investigated achieve maximum utilization function study master logic diagram analysis identifying differences sit safety injection pump accident case classification used determine parameters sit operation conditions require use sit determined using decision making process proper timing using sit also analyzed using multi dimensional analysis reactor safety mars code korea atomic energy research institute daejeon south korea operation strategy analysis indicates sit mitigate five types failure failure safety injection pump failure passive auxiliary feedwater system failure depressurization system failure shutdown cooling pump scp failure recirculation system results mars code demonstrate time allowed recovery extended using sit compared situation sit used based results use sit recommended especially pilot operated safety relief valve posrv opened copyright published elsevier korea llc behalf korean nuclear society
empirical basis determining seasonal affective disorder sad patients best suited type treatment using data parent clinical trial comparing light therapy cognitive behavioral therapy cbt combination cbt sad constructed hierarchical linear regression models explore baseline cognitive vulnerability constructs dysfunctional attitudes negative automatic thoughts response styles prognostic prescriptive factors acute next winter depression outcomes cognitive constructs predict moderate acute treatment outcomes baseline dysfunctional attitudes negative automatic thoughts prescriptive next winter treatment outcomes participants higher baseline levels dysfunctional attitudes negative automatic thoughts less severe depression next winter treated cbt treated addition participants randomized solo scored sample mean cognitive measures baseline severe depressive symptoms next winter relative scored mean baseline dysfunctional attitudes negative automatic thoughts predict treatment outcomes participants assigned solo cbt cbt therefore sad patients extremely rigid cognitions fare well subsequent winter treated initially solo patients may better suited initial treatment cbt directly targets cognitive vulnerability processes elsevier ltd rights reserved
objectiveto study association body composition measures menstrual status large sample adult patients history anorexia nervosa calculate predicted probability resumption menstrual function furthermore establish whether fat percentage superior body mass index predicting resumption menses methodone hundred thirteen adult women history anorexia nervosa underwent dual energy ray absorptiometry dxa scan completed questionnaires regarding medication prescription menstrual function resultsfifty percent patients expected resume menstrual function body mass index fat percentage twenty five percent patients expected resume menstrual function body mass index fat percentage fat percentage body mass index equally capable predicting resumption menses discussionfat percentage body mass index positive predictors resumption menses however body composition measured dual energy ray absorptiometry superior body mass index predicting menstrual recovery great clinical relevance body mass index easier cheaper obtain body composition measures account one numerous factors involved resumption menses regression models based data value indicating variation menstrual recovery could explained variables included wiley periodicals inc int eat disord
examined relation emotion susceptibility misinformation using novel paradigm ambiguous stimuli affective priming asap paradigm participants viewed ambiguous neutral images primed either encoding retrieval interpreted either highly positive negative neutral primed viewing images either asked misleading non leading questions following delay memory accuracy original images assessed results indicated emotional priming encoding led higher susceptibility misinformation relative priming recall particular inducing negative interpretation image encoding led increased susceptibility false memories major misinformation entire object actually present scene contrast pattern reversed priming used recall negative reinterpretation image decreased memory distortion relative unprimed images findings suggest precise experimental control experience emotion event encoding particular implicated false memory susceptibility
background gesture often used modality promote recovery communication aphasia compensation device facilitator language recovery date systematic analysis quantitative effects gesture training aphasia light quality research methods undertaken aims aim current project systematically evaluate scientific evidence effects symbolic nonsymbolic gestural training post stroke aphasia specifically aimed evaluate effects gesture treatment measures verbal nonverbal communication methods procedures systematic search literature conducted august september relevant electronic databases utilising search terms study characteristics summarised methodological quality studies independently rated first two authors using pedro sced scales group single case experimental designs sceds respectively effect sizes calculated none provided original manuscript results initial search yielded citations met inclusion exclusion criteria group designs sceds individuals participated studies majority nonfluent moderatesevere chronic aphasia methodological rigour weak group studies sceds achieved high quality scores higher gesture training alone nonsignificant effects verbal production combined gesture verbal training showed positive effects verbal production nouns verbs participants mixed pattern generalisation untrained words contexts gesture verbal training paradigms limited advantage verbal training alone significant gains gesture production reported trained gestures following gesture training protocols studies examined generalisation discourse effects training nonsymbolic gestures less conclusive conclusions comparative effect sizes support benefit combined gesture verbal treatment noun verb production individuals aphasia whether benefit surpasses results verbal treatment alone well established symbolic gestures acquired individuals aphasia although communicative effectiveness requires study overall gestural training aphasia generating positive outcomes relatively understudied need large scale investigation taking account considerable participant variability
background objectiveover last years bioactive plant food compounds received considerable attention regard beneficial effects periodontal disease study investigated effects black tea theaflavins tfs virulence properties porphyromonas gingivalis gingival keratinocyte tight junction integrity addition effects black tea tfs nuclear factor signaling pathway proinflammatory cytokine matrix metalloproteinase mmp secretion monocytes macrophages assessed material methodsvirulence factor gene expression gingivalis investigated quantitative real time pcr fluorescence assay used determine gingivalis adherence invasion gingival keratinocyte monolayer tight junction integrity gingival keratinocytes assessed determination transepithelial electrical resistance proinflammatory cytokine mmp secretion gingivalis stimulated macrophages quantified elisa luc monocyte cell line transfected luciferase reporter gene used monitor activation gelatin degradation monitored using fluorogenic assay resultsblack tea tfs dose dependently inhibited expression genes encoding major virulence factors gingivalis attenuated adherence gingival keratinocytes treatment gingival keratinocytes black tea tfs significantly enhanced tight junction integrity prevented gingivalis mediated tight junction damage well bacterial invasion black tea tfs reduced secretion interleukin tumor necrosis factor chemokine ligand mmp mmp mmp gingivalis stimulated macrophages attenuated gingivalis mediated activation signaling pathway lastly black tea tfs inhibited gelatin degradation mmp conclusionthis study provides clear evidence black tea tfs represent promising multifunctional therapeutic agents prevention treatment periodontal disease
electrochemical immunosensors potential transform analytical procedures within food industry providing highly specific rapid inexpensive determination pathogens paper recent advances area outlined particular attention paid new methods developed modification working electrode surfaces many advances related use novel nanomaterials carbon nanotubes graphene metallic nanoparticles often used conjunction polymers use materials generally provided superior sensor sensitivity application immunosensors detection range pathogens real samples investigated establish whether provide solutions practical applications
collection storage management anticipation contextual information user support decision making constitute key operations ambient intelligent ami systems instructor computer based class often difficult confirm students working proposed activities order mitigate problems might occur environment learning technologies suggest ami system aimed capturing measuring supervising students level attentiveness real scenarios dynamically provide recommendations instructor system possible assess individual group attention real time providing measure level engagement student proposed activities allowing instructor better steer teaching methodologies
applied computer laboratory lessons could unproductive many students correcting students mistakes one one wasting lesson time especially beginners mistakes caused complex integrated development environments study develop client server application computer laboratories developed application able compile programming language source code remotely thus students need make something writing source code furthermore instructors need install compiler computer laboratory start lesson enough server configured authors published elsevier ltd
present study examined mediators moderators relation parental adhd symptomatology development child attention deficit hyperactivity disorder adhd oppositional defiant disorder odd symptoms across preschool years participants included boys year old children months without behavior problems parents took part year longitudinal study maternal adhd symptoms predicted later adhd symptoms children controlling early child symptomatology family history adhd paternal comorbid psychopathology predicted later child adhd odd symptoms account association maternal child adhd symptoms although paternal adhd symptoms associated age child adhd symptoms significantly predict later child adhd symptoms controlling early symptomatology family adversity moderated relation maternal adhd child adhd symptoms relation maternal child adhd symptoms stronger families less adversity maternal overreactive parenting mediated relation maternal adhd symptoms later child adhd odd symptoms findings suggest targeting paternal comorbid psychopathology maternal parenting holds promise attenuating effects parental adhd children adhd
torsional buckling failure carbon fiber epoxy resin composite thin walled tubes ctwts tested analyzed effects torsional buckling material failure failure loads simulated finite element method order enhance torsional bearing capacity ctwts buckling failure tubes filled polymer foam simulated abaqus numerous simulation results show buckling tube strongly inhibited foam core torque usage crushable foam material influence elastic modulus yield strength foam materials torsional failure modes loads studied elastic modulus yield strength increasing buckling failure load ctwts gradually increases reaches ultimate permitted strength materials reasonable selection core material help obtain higher bearing capacity make full use high strength properties composite materials
present work aims develop methodology classifying lung nodules using lidc idri image database proposed methodology based image processing pattern recognition techniques describe texture nodule non nodule candidates use taxonomic diversity taxonomic distinctness indexes ecology calculation indexes based phylogenetic trees work applied candidate characterization finally apply support vector machine svm classifier testing stage used exams lidc idri image database apply methodology divided complete database two groups training testing used training testing partitions division repeated five times random presented methodology shows promising results classifying nodules non nodules presenting mean accuracy lung cancer presents highest mortality rate one lowest survival rates diagnosis therefore earlier diagnosis higher chances cure patient addition information available specialist precise diagnosis methodology proposed contributes
introductionasymmetric dimethylarginine adma nitric oxide show mechanism action reciprocally balance molecules contributes tight regulation airways tone function objectivesthe aim study determine serum levels adma patients chronic obstructive pulmonary disease copd establish whether level vary relation forced expiratory volume fev assess role pathophysiology copd materials methodsthis study consisted patients copd healthy subjects serum adma levels measured using enzyme linked immunosorbent assay colorimetric method respectively resultsserum adma levels significantly higher however levels lower patients copd compared controls adma levels inversely correlated levels serum adma significantly correlated fev multivariable logistic regression analysis revealed serum adma independently significantly associated presence copd multiple linear regression analysis showed copd positively associated adma additionally copd adma independently inversely associated levels decreased adma levels increased compliant progression copd stages conclusionwhile circulating adma higher lower copd show strong correlation degree airflow limitation adma seems possible new marker prognosis copd novel therapeutic target treatment copd
background patients suffering depression experience significant mood anxiety cognitive symptoms currently antidepressants work altering neurotransmitter activity brain improve symptoms however last decade research revealed extensive bidirectional communication network gastrointestinal tract central nervous system referred gut brain axis advances field linked psychiatric disorders changes microbiome making potential target novel antidepressant treatments aim review analyze current body research assessing effects probiotics symptoms depression humans methods systematic search five databases performed study selection completed using preferred reporting items systematic reviews meta analyses process results ten studies met criteria analyzed effects mood anxiety cognition five studies assessed mood symptoms seven studies assessed anxiety symptoms three studies assessed cognition majority studies found positive results measures depressive symptoms however strain probiotic dosing duration treatment varied widely studies assessed sleep conclusion evidence probiotics alleviating depressive symptoms compelling additional double blind randomized control trials clinical populations warranted assess efficacy
space filling visualization model first invented ben shneiderman maximizing utilization display space relational data graph visualization especially tree visualization uses concept enclosure dismisses edges graphic representation frequently used traditional node link based graph visualizations therefore major issue graph visualization edge crossing naturally solved adoption space filling approach however past space filling concept attracted much attention researchers field multidimensional visualization although problem edge crossing also occurred among polylines used basic visual elements parallel coordinates visualization problematic edge crossings among polylines evenly distributed display plate visual clutter occur problem could significantly reduce human readability terms reviewing particular region visualization study propose new space filling multidimensional data visualization sfmdvis first time introduces space filling approach multidimensional data visualization main contributions achieving maximization space utilization multidimensional visualization display area fully used eliminating visual clutter sfmdvis use non classic geometric primitive improving quality visualization visual perception linear correlations among different variables well recognizing data patterns evaluate quality sfmdvis conducted usability study measure performance sfmdvis comparison parallel coordinates scatterplot matrix finding linear correlations data patterns evaluation results suggested accuracy sfmdvis better terms perceiving linear correlations also sfmdvis efficient less time required recognizing data patterns elsevier inc rights reserved
study thermodynamic description system presented phase diagram data structural information thermochemical data used assessment solution phases modeled using compound energy formalism addition heat capacity measurement mgmno mgmno phases reported thermodynamic description reproduces thermochemical structural phase diagram data
background prevention ige binding cellular ige receptors anti ige omalizumab clinically effective allergic asthma limited ige threshold levels overcome limitation developed single use ige immunoadsorber column igenio igenio based recombinant ige specific antibody fragment used specific extracorporeal desorption ige objective study safety efficacy igenio regarding selective depletion ige randomized open label controlled pilot trial patients allergic asthma investigate igenio bind ige omalizumab immune complexes methods fifteen subjects enrolled randomly assigned treatment group control group immunoadsorption done veno venous approach processing twofold calculated plasma volume treatment minimum average ige depletion last cycle intention treat population defined primary endpoint safety treatment studied secondary endpoint addition possible changes allergen specific sensitivity investigated well clinical effects peak flow measurement symptom recording depletion ige omalizumab immune complexes studied vitro study registered clinicaltrials gov nct conducted december july results ige immunoadsorption igenio selectively depleted ige end last cycle removal pollen allergen specific ige associated reduction allergen specific basophil sensitivity prevented increases allergen specific skin sensitivity clinical symptoms pollen seasons igenio also depleted ige omalizumab immune complexes vitro therapy investigation safe well tolerated total aphereses severe adverse events sae recorded one episode acute dyspnea possibly related treatment resolved administration antihistamines corticosteroids conclusions pilot study indicates ige immunoadsorption igenio may used treat patients pollen induced allergic asthma furthermore treatment could render allergic patients highly elevated ige levels eligible administration omalizumab facilitate desorption ige omalizumab complexes study funded fresenius medical care deutschland gmbh bad homburg germany authors published elsevier
wind turbine emulator important hardware simulate wind energy conversion systems emulator hardware often built coupled motor prime mover controlled variable speed drive shaft electrical generator work propose design implement novel wind turbine emulator using squirrel cage induction machine permanent magnet induction generator control prime mover performed igbt drive drive controlled bit microprocessor furthermore computer supervises drive generates wind patterns sets configuration wind turbine models allows user define different wind patterns emulate different wind turbines combination controller computer supervision microprocessor ensures accurate performance entire system frequency generated voltage proportional shaft rotational speed therefore output voltage frequency used rotational speed meter main communication channel drive computer finally results demonstrate effective accurate performance proposed emulator reproducing dynamics actual wind turbine elsevier ltd rights reserved
position women society women role society always debated along men turkey well lot discussion women social position main aim study evaluate women issues context gender roles focusing novels three writers different periods turkish political history study first ottoman era writer fatma aliye hanim novel muhederat rebuplican era writer adalet agaoglu novel olmeye yatmak finally contemporary writer ayfer tunc novel yesil peri gecesi analyzed gender roles characters one novel writer chosen exceed time limit congress report scope research literature review done observed works reviewed general comments made single period time moreover purpose addressing different time periods examine changes women issues throughout history changes social structure concepts female male relations family social gender work politics freedom characters novels even though women problems still exist results indicate women changed social perception increasing awareness result effort conclusion paper facilitates understanding providing opportunity compare social opinion three writers different periods showing progress writers made providing opportunity interdisciplinary vision literature social structure also provide convenience researchers different disciplines future studies
prevalence self injurious behavior sib high among children autism spectrum disorder asd identification risk factors development sib critical early intervention prevention however little empirical research utilizing prospective design identify early risk factors sib purpose study evaluate behavioral characteristics predicting sib age years among infants high familial risk asd logistic regression results indicated presence sib proto sib lower developmental functioning age months significantly predicted sib months pattern persistent sib period associated diagnosis autism poorer cognitive adaptive outcomes
goal study demonstrate whether increased fluoride uptake lesions positron emission tomography pet scan predict new syndesmophyte development patients ankylosing spondylitis patients fluoride pet magnetic resonance imaging mri performed baseline radiography performed baseline year follow following data recorded presence increased fluoride uptake lesions pet defined uptake greater uptake adjacent normal vertebral body acute type advanced type corner inflammatory lesions cils fat lesions mri syndesmophytes radiography anterior vertebral corners without syndesmophyte baseline type cils type cils fat lesions mri six increased fluoride uptake lesions pet observed year follow new syndesmophytes eight patients occurred new syndesmophytes developed significantly frequently anterior vertebral corners increased fluoride uptake lesions fat lesions baseline without lesions respectively adjusting confounding factors baseline increased fluoride uptake lesions independently associated new syndesmophytes development fat lesions also associated new syndesmophytes formation data suggest fluoride pet may applied identify patients high risk future syndesmophyte formation
chronic hepatitis virus hev infection may occur immunocompromised patients previous studies report different immunosuppressive agents interfere viral replication however role tnf alpha hev infection currently unknown describe case severe exacerbation chronic hev infection patient undergoing treatment tnf alpha inhibitor psoriatic arthritis despite potent anti hev cell responses used state art hev cell culture methods test antiviral effects different drugs cytokine release assay assess hev specific cell immunity addition standard tools diagnostics laboratory employed vitro data confirmed inhibition hev replication tnf alpha could abolished addition tnf alpha inhibitors thus tnfa may play critical role control hev replication therefore recommend exclusion hev infection prior initiation tnf alpha inhibitor therapy societe francaise rhumatologie published elsevier masson sas rights reserved
service reputation key factor service selection service composition service oriented ambient intelligence systems hence service reputation computing fully reflect feature multi rating fusion utility value dynamic attenuation characters rating paper combines evidence theory dynamic attenuation puts forward service reputation computing algorithm based multi rating fusion adapted ambient intelligence systems first layered computing model service reputation given mechanism dynamic attenuation based time windows objective rating advertisement honesty rating service user credibility computing algorithm presented afterward rating information combined evidence theory raise aggregation algorithm service general reputation ambient intelligence environments finally prototype test carried verify effectiveness availability model together algorithms
electrical variable transmission evt electromagnetic device dual mechanical electrical ports hybrid electric vehicles hev used split power wheels part coming combustion engine part exchanged battery important feature power splitting done electromagnetic way advantage mechanical power splitting devices reduced maintenance high efficiency inherent overload protection depending operating point part power transmitted electromagnetic way rest transmitted electrically using two back back inverters power flow determines power rating inverters cooling machine design paper gives overview different operating points corresponding power flow
objective zeneo needle free injection device performed pharmacokinetic study investigate bioequivalence methotrexate administered subcutaneously using either needle free injection device conventional needle syringe research design methods single dose open label laboratory blind randomized crossover study performed adult healthy volunteers participant received two methotrexate injections one via needle free injection device one via conventional injection day wash interval dosing participant administration site injections either abdomen thigh main outcome measures primary pharmacokinetic outcome parameters auc max bioequivalence assessed standard criteria whether confidence intervals geometric mean ratios two administration methods within results fifty two individuals completed study bioequivalence criteria met auc overall analysis injection sites confidence interval injection site separately bioequivalence similarly demonstrated auc bioequivalence criteria max fulfilled abdominal administration overall analysis injection via needle free injection device well tolerated limitations limitations include conducting study healthy volunteers relatively small subject number albeit satisfactory bioequivalence conclusions study shows methotrexate injection via needle free injection device bioequivalent conventional needle syringe relation auc auc studies needle free injection device use patients requiring methotrexate therapy planned
brain glucose uptake declines aging significantly impaired alzheimer disease ketones main alternative brain fuel glucose represent potential approach compensate brain glucose reduction caffeine interest potential ketogenic agent owing actions lipolysis lipid oxidation whether ketogenic humans unknown study aimed evaluate acute ketogenic effect doses caffeine healthy adults caffeine given breakfast significantly stimulated ketone production dose dependent manner also raised plasma free fatty acids whether caffeine long term ketogenic effects could enhance ketogenic effect medium chain triglycerides remains determined
background compare outcomes individuals major depressive disorder mdd without subthreshold hypomania mixed features naturalistic settings methods using optum research database retrospective analysis individuals newly diagnosed mdd conducted continuous enrollment months initial mdd diagnosis required mdd subthreshold hypomania mixed features mdd defined based hypomania diagnosis within days mdd diagnosis one year follow period absence bipolar diagnoses psychiatric medication use healthcare utilization costs one year follow period compared using multivariate logistic gamma regressions controlling baseline differences results mdd individuals met operational definition mdd compared mdd group mdd group suicidality anxiety disorders substance use disorders individuals mdd treated antidepressants mood stabilizers atypical antipsychotics polypharmacy multiple drug classes individuals mdd higher hospitalizations rates total healthcare costs mean limitations commercial claims data used collected research purposes may represent certain populations specific claims based diagnostic code mdd mixed features exists conclusions greater use mood stabilizers atypical antipsychotics polypharmacy healthcare resources provides evidence complexity severity mdd identifying optimal treatment regimens population represents major unmet medical need
paper general model transient dynamic analysis functionally graded material fgm thick arch ring introduced material arbitrarily distributed metal aluminium steel ceramic alumnina silicon carbide phases according several types functional distributions including exponential law power law sigmoid law among others model developed within context strength materials theory includes many others theories particular cases example timoshenko beam first order shear deformation theories material properties young modulus shear modulus density arbitrarily vary along generally shaped cross section multiply connected region however holding symmetry respect motion plane tangential stresses consistently featured classical internal equilibrium equations polar coordinates allows proper calculation shear coefficient crucial class theories three fully coupled motion equations solved order carry studies natural vibrations well transient dynamics general type applied loads transient solution reached means modal superposition method appealing hoc orthogonality conditions numerical studies presented show qualitatively quantitatively vibratory features ceramic metallic thick arches rings graded properties elsevier ltd rights reserved
background surgical interventions commonly advocated correcting kyphotic deformities relieving severe back pain ankylosing spondylitis patients aim study evaluate clinical outcome osteotomy performed gap pathological fracture treatment kyphosis ankylosing spondylitis introduce key points novel surgical approach methods january december consecutive patients treated osteotomy fracture gap retrospectively reviewed patients underwent radiographic assessment sagittal balance parameters visual analog scale vas scores used assess improvement back pain results average follow time years month median operation time min range min mean blood loss range major acute complications death complete paralysis occurred neurologic complications cerebrospinal fluid leaks patient one patient postoperative wound infection subsided switch antibiotics global kyphosis cobb angle patients decreased preoperative degrees degrees degrees degrees surgery plumb line used assess global balance relationship posterosuperior corner sacrum decreased thoracolumbar kyphosis cobb angle decreased degrees degrees degrees degrees vas scores back pain decreased lumbar lordosis increased degrees degrees degrees degrees conclusions osteotomy pathological fracture gap safe effective surgical procedure kyphosis correction improvement back pain patients pathological fractures significant kyphosis correction improvement back pain achieved surgical procedure
background study aimed elucidate previously observed associations morningnesseveningness depressive symptomatology university students relations components depressive symptomatology morningness eveningness analysed methods nine hundred seventy four university students completed polish versions centre epidemiological studies depression scale ces polish translation appended paper composite scale morningness principal component analysis pca used test structure depressive symptoms pearson partial correlations age sex controlled along regression analyses morning affect circadian preference predictors used results pca revealed three components depressive symptoms depressed somatic affect positive affect interpersonal relations greater related less depressive symptoms three components morning circadian preference related less depressive symptoms depressed somatic positive affects unrelated interpersonal relations morningness eveningness components exhibited stronger links depressed somatic positive affects interpersonal relations three ces components exhibited stronger links circadian preference regression analyses statistically significant positive affect better interpersonal relations whereas depressed somatic affect predicted lower morning circadian preference relationship reversed compared correlations limitations self report assessment conclusions three groups depressive symptoms polish university students associations depressed somatic positive affects primarily responsible observed links morningness eveningness depressive symptoms university students people evening circadian preference whose lowered less depressed somatic affect elsevier rights reserved
common engineering problem manufacturing identifying many possible factors influences response interest words causing performance reliability quality cost issue evolutionary operations commonly called evop harnesses muscle manufacturing operations generate large data sets minimal disruption factory capture natural variance materials processes materials used manufacture product supersaturated experiments methods guide experimental plans supports statistical analysis data upon sound conclusions interpretations drawn paper presents methods applied together problem screening many factors find influence particular response interest case study virtual cell factory presented
investigation paper fourth order variable coefficient nonlinear schrodinger equation describe inhomogeneous one dimensional anisotropic heisenberg ferromagnetic spin chain alpha helical protein aid hirota method symbolic computation bilinear forms dark one two soliton solutions obtained influences variable coefficients dark one two solitons graphically shown discussed amplitude shape dark one soliton keep invariant propagation variable coefficients chosen constants variable coefficients functions amplitude dark soliton keeps unchanged propagation direction soliton curves head overtaking collisions dark two solitons displayed variable coefficients chosen constants shown shapes two solitons change collision choose variable coefficients functions directions two solitons change elastic collisions occur two solitons
paper investigates robust control invariance boolean control networks bcns via semi tensor product matrices firstly based algebraic state space representation bcns two necessary sufficient conditions presented check whether given set robust control invariant set given state feedback controller secondly defining series suitable sets possible state feedback gain matrices given set robust control invariant set characterized illustrative example presented demonstrate obtained new results elsevier ltd rights reserved
recent paper fernandez argues memory distortion beneficial outcomes although agree find reasoning examples flawed degree lead misunderstandings rather clarification field memory distortion paper fernandez uses terms belief memory incorrectly creating conceptual blur also fernandez tries make case certain circumstances false memories abuse beneficial argue idea reasoning behind claim based controversial assumptions repression although true memory distortions beneficial examples sketched fernandez line recent documentation area elsevier inc rights reserved
universal mobile telecommunication system umts growth enormous variety applications interactive services work propose complement services complete access anywhere time umts services units involves satellite segment complements terrestrial one offer global mobile communication service satellite component aims extend enhance existent units terrestrial radio access network utran referred umts satellite radio access network usran paper alternatives architecture scenarios proposed analysed respective protocols stack performance testing
social sexual networking technologies reported yield psychosocial benefits sexual risks gay bisexual men yet little research explored technology interacts social geographical environment shape health gay bisexual men relatively understudied environment small cities article draws semistructured interviews examining use social sexual networking technologies among racially diverse gay bisexual men two small cities questions probed participants use technology meet sexual partners engagement gay community role virtual nonvirtual spaces relation health findings suggest social networking technologies help men navigate challenges small cities including small insular gay communities lack dedicated gay spaces sexual minority stigma however participants also describe declines gay community visibility cohesion attribute technology use article concludes discussing intersections virtual physical space small cities sites production health illness
purpose purpose paper study corrosion behavior cryorolled cryorolled short annealed commercially pure aluminum percent nacl solution design methodology approach cast homogenized samples cryorolled degrees samples short annealed degrees min transmission electron microscope studies performed understand effect cryorolling short annealing microstructure corrosion behavior samples percent nacl solution evaluated potentiodynamic polarization studies findings though cryorolling adversely affects corrosion resistance short annealing restore loss corrosion resistance partially recovery process extent restoration loss corrosion resistance short annealing influenced texture originality value results obtained investigation help understanding effect cryorolling short annealing corrosion behavior
contribution presents functionalities multimedia contents learning module virtual prototyping garments within erasmus project entitled learning course innovative textile fields advantex use advanced information technologies systems assure textile garment manufacturing companies competitive advantages high constant quality products productivity flexibility quick response requirements fashion market wide range new technologies using fascinating possibilities computer graphics together new generation computer based systems assure textile companies ability react extremely fast customer demands offering quality future oriented services enables greater commercial presence contributes company better marketing position universities research institutions software producers apply nowadays whole range new technologies create advanced computer solutions future support whole cycle starting virtual design fabric garments automated production virtual merchandising therefore students textile professionals already working textile industries given knowledge needed successful work new technologies contribute developing textile information society future module learning course innovative textile field informs readers course participants new emerging technologies great potential textile related industries virtual prototyping garments scanning
need understand control strategies utilized humans everyday activity requires measurement several variables pertain different aspects interaction environment work focuses validation uncertainty quantification sensor fusion suite acquisition biometric information used estimation control strategy variety everyday tasks specifically acquisition biomechanical parameters involving estimations human ankle mechanical impedance addressed sensor fusion suite devised consists centralized program synchronize integrate information coming several transducers work system combines set two computer vision cameras cameras utilize stereovision algorithm transforms markers acquired cartesian space model camera space furthermore biomechanical model human integrated system reconstruction tracked movements joint space architecture systems allows integration transducers beyond implemented date including inertial measurement units electromyography pressure sensors system able capture dynamics inverted pendulum cart mimicking human walking treadmill mechanical parameters ankles estimated simulating single stand phase
years uncanny valley model captivated researchers various fields expertise still explanations slightly imperfect human like characters evoke feelings eeriness remain subject controversy many experiments exploring phenomenon emphasized specific visual factors connection evolutionary psychological theories underlying categorization conflict recently studies also shifted away focus appearance human like entities instead exploring mental capabilities basis observers discomfort order advance perspective introduced participants virtual reality chat program presented two digital characters engaged emotional empathic dialogue using prerecorded scene manipulated perceived control type depicted characters human controlled avatars computer controlled agents well alleged level autonomy scripted self directed actions statistical analyses revealed participants experienced significantly stronger eeriness perceived empathic characters autonomous artificial intelligences human likeness attractiveness ratings result significant group differences present results evidence uncanny valley mind relies attribution emotions social cognition non human entities possible relationship philosophy anthropocentrism threat human distinctiveness concept discussed elsevier rights reserved
dna methylation level certain gene region considered new type biomarker diagnosis miniaturized rapid detection system required diagnosis developed simple electrochemical detection system dna methylation using methyl cpg binding domain mbd glucose dehydrogenase gdh fused zinc finger protein analytical system consists three steps methylated dna collection mbd pcr amplification target genomic region among collected methylated dna electrochemical detection pcr products using gdh fused zinc finger protein system successfully measured methylation levels promoter region androgen receptor gene copies genomic dna extracted tsu cancer cell lines since sequence analysis enzymatic digestion required detection system dna methylation levels measured within simple procedure
study hydraulic anatomy function trees long tradition motivated current projected changes water availability field tree hydraulics experiencing bout activity significant progress made understanding water transport trees organized integrates physiological processes andwhat takes malfunction many advances possible fields research traditionally separate aremerging example wood anatomy plant ecophysiology developments led creation powerful novel approaches help answer longstanding questions relating fundamental aspects fluid transport plants andhowplants survive face environmental stresses drought freezing increased capacities visualize ultrastructures wood ever greater detail ability situ visualization long distance fluid transport contributed progress review provides entry point vast continuously increasing knowledge water transport trees organized scales cells tissue anatomy whole tree physiology landscape ecology known mechanisms novel conceptual theories aroundhowtrees die aswell ways prevent fate summarized high priority research questions coming years formulated
short discussion goldi remote lab infrastructure new experiment control panel ecp integrated graphical interactive finite state machine toolset gift main focus paper interconnection multiple remote labs based goldi infrastructure remote lab cloud within two running tempus projects ten remote labs four countries used worldwide based cloud structure necessary adapt complex goldi access control system new reservation system possibilities effective worldwide experiment management available described article
human immunodeficiency virus acquired immune deficiency syndrome hiv aids disproportionately burdens african american youth young adults studies conducted historically black colleges universities hbcu settings african american youth generally perceive low risk contracting hiv sexually transmitted diseases stds despite higher rates unprotected sexual encounters multiple sex partners particularly low rates hiv testing awareness hiv status findings position hbcus pivotal role theory based research practice modify behaviors order decrease hiv acquisition risk get students mobilized retooled transform smart interventional research project urban hbcu northeastern metropolitan area project designed assess address irresponsible behavior among students college campuses leads illicit drug use excessive alcohol consumption underage drinking risky sexual behaviors increase likelihood acquiring hiv stds gender plays critical role interventions article explores gender similarities differences inform planning implementation get smart subsequent projects address substance alcohol use hiv hbcu setting survey research conducted find similar different factors may valuable implementing tailoring evidence based interventions predominantly african american campus setting survey results revealed young adult women consume alcohol use marijuana young adult men young adult men also likely tested hiv compared young adult women
non uniform flow patterns distillation trays result significant losses separation efficiency compared conditions straight chordal flow paths improve flow pattern via tray design revamps well accurate prediction achievable separation efficiency better understanding flow formation required however straight forward since evolving patterns depend column tray design well operating conditions may cover configurations continuous liquid pushed curtain rising bubbles bubble regime continuous gas phase carrying liquid droplets spray regime study wire mesh sensor technique used visualize flow patterns larger trays technique tracks conductivity tracer pulses passage across tray proper calibration routine developed methodology proposed determine point liquid residence time distributions weir weir liquid velocities experiments carried tray column diameter feasibility study included experiments different liquid capacities various outlet weir obstructions tray benchmark data high spatio temporal resolution obtained suitable validation cfd models flow simulation industrial scale sieve trays institution chemical engineers published elsevier rights reserved
introduction although studies show importance physical activity prevention maintaining healthy standard living practice determine increased risk occurrence injuries among people practice sports activities objective determine prevalence factors associated injuries leisure time physical activity practice city pelotas brazil methods population based cross sectional study conducted urban area pelotas southern brazil sample taking account different clusters selected sociodemographic economic behavioral nutritional physical activity injury related characteristics collected using standardized pre coded questionnaire results prevalence injuries subjects physically active leisure time prevalent injuries contusions dislocations sprains soccer practice weightlifting activities injuries occurred injuries associated male gender younger age black mixed race conclusion although prevalence injuries among practitioners important benefits active lifestyle outweigh risks
present network control systems employ common approximation solve connectivity issue due time delays coupled external factors however approach tends complex terms time delays inherent local phase missing therefore necessary study behavior delays well integration differential equations bounded delays related time delays need known priori dynamic real time perspective order understand dynamic phase behavior objective paper demonstrate inclusion data frequency transmission time delays bounded parameters dynamic response real time scheduling approximation considering local phase situation related control law designed considering fuzzy logic approximation nonlinear time delays coupling main advantage integration behavior extended state space representation keeps certain linear bounded behavior leading stable situation events presentation based accurate data transmission rate expected result basics local phase missing result local bounded time delays lack tide synchronization conforms modeling approximation
paper discusses engagement furniture design environmental elements ecological system design literature purpose establish gap area ecological design sustained relationship field study resulted two major areas designs industrial design manufacturing technology design one minor field found business industrial marketing term describes creative thinking involved industrial cycle methodologies instead aesthetics ergonomics applies manufacturing engineering principles develop ecological system forms design term structured measures commonly applied manufacturing industrial technology engineering another prominent term green design manufacturing environmentally conscious manufacturing ecm means material sources processed systems producing goods several operations large production scale meet ecological consumer behaviour materials must specified earliest stages due design production stages furthermore remains minor area slightly important since environmental communication derived ecological system issues based greenhouse gases ghg function initiative drives business business communication could considered ecological economics player normally manufacturing sector complies national economic transformation agenda international intention finally combination three areas study may lead probable finding ecological influence elements extraction environmental design standards theory hence topic focus criteria capability characteristics ecological system awareness producing recycling product design forms context help practicing designers identify problems issues gaps relation ecological concept using suitable methodologies applications
postharvest pathogen penicillium digitatum responsible green mold decay citrus fruit causing important economic losses examine possible elements involved fungal pathogenesis virulence fungicide resistance identification functional characterization pdste particular type fungal transcription factor carried pdste functionally inactivated homologous recombination deletant fungal strains delta pdste failed cause green mold decay citrus fruit delta pdste mutants exhibited reduced growth impaired conidiogenesis fungal infection towards citrus fruit additionally pdste characterized via overexpression transformants showing higher infectivity rate low virulence digitatum strain providing evidence pdste role virulence moreover fungicide sensitivity evaluation showed pdstel involved fungicide resistance transcription factors results indicate pdstel transcription factor controls invasive growth asexual reproduction major virulence function elsevier rights reserved
paper deals dynamical modelling view behavior analysis double stars induction machine dsim supplied voltage source pwm inverter two modelling approaches elaborated first one stator armatures dsim described two coupled circuits concordia frame second approach stator armatures dsim described two decoupled circuits one equivalent model three phase machine concordia frame equivalent passive circuit produce torque based established electrical circuits effect supply mode increasing inverter level current quality torque ripples analyzed
fused deposition modeling fdm recognized effective technology manufacture dimensional parts directly digital computer aided design cad model layer layer style although become significantly important manufacturing process still well accepted additive manufacturing technology load carrying parts dynamic cyclic conditions due many processing parameters affecting part properties purpose study characterize fdm manufactured parts detecting individual interactive fdm process parameters influence performance manufactured products dynamic cyclic conditions experiments conducted fractional factorial design artificial neural network ann effect parameter dynamic modulus elasticity investigated using analysis variance anova technique furthermore optimal processing parameters determined validated conducting verification experiment results showed ann fractional factorial models provided good quality predictions yet ann showed superiority properly trained ann capturing nonlinear relationship system fractional factorial data fitting estimation capabilities pei university maribor rights reserved
approach psychological profile vulnerability injury athlete become necessary competitive sports subjects consisted total sample males non injured females non injured male athletes average age years female athletes years sample consisted athletes individual sports tennis athletics swimming players team sports football basketball handball belonging different sports clubs valencian community sport competitive anxiety test scat used evaluation competitive anxiety epr scale used evaluate hardiness competitiveness scale used assess competitiveness specific registration form used assessment injury study carried basing quantitative methodology design study observational descriptive correlational study based hypothesis number injuries increase lower levels hardiness success oriented motivation higher levels competitive anxiety motivation addressed avoid failure objective analyze differences number injuries among athletes profile vulnerability injury low hardiness high competitive anxiety low motivation success high motivation oriented avoid failure fit profile according theoretical foundation placed profile would susceptible injury however results study indicate men profile vulnerability injury sustain injuries suffered fewer moderate injuries total number injuries rate injury lower results discussed conclusions study indicated
paper switching flow graph models developed study nonlinear behavior switching converters based concept virtual switches virtual switching functions switching flow graph sfg model created easily without complex mathematics sfg modeling technique helpful undergraduate students beginners understand switching converters operate different switching states students also learn develop model observe cause effect relationship converter variables research basic cuk converter used example reveal dynamic behavior switching converters operated dcm ccm students enhance concept circuit design developing sfg model software simulate various conditions
background osteoarthritis knee involves degeneration articular cartilage diarthrodial joints current treatment options temporarily relieve joint pain restore lost cartilage recently designed novel bone morphogenetic protein receptor type bmpri mimetic peptide activates bmpria signaling absence bone morphogenetic protein bmp previous research demonstrated induced chondrogenesis vitro vivo however unknown restores damaged articular cartilage vivo study demonstrate induced articular cartilage repair mouse model methods designed hyaluronic acid based hydrogel particles hgps slowly release hgp particles tested chondrogenic potency pluripotent mesenchymal stem cells cht cells locally injected intra articular capsule mice cartilage defects cbl mice operated destabilize medial meniscus mice kept weeks surgery sustain like damage mice injected via intra articular capsule hgp weeks injection mice sacrificed femurs analyzed cartilage defects results immunohistochemical analysis cartilage demonstrated complete repair compared sham operated mice immunofluorescence analysis revealed collagen type production along collagen type mice injected hgp mice injected phosphate buffered saline pbs hgp alone greater collagen type osteocalcin production sharp contrast injected hgp indicating increased chondrocyte hypertrophy conclusions results demonstrate slow release hgp drives cartilage repair without induction chondrocyte hypertrophy peptide could powerful tool understanding signaling pathways contributing repair process also may used potential therapeutic treating degenerative cartilage diseases
studies identified prenatal flavour exposure determinant taste preferences infants however studies focused relatively small samples limited flavours many parents struggle getting children accept variety nutritious foods study factors influencing food acceptance warranted objective study determine whether exposure wider variety fruit vegetables overall higher diet quality utero results acceptance greater variety foods better diet quality offspring childhood study secondary data analysis pregnant women resulting offspring recruited women children health study nsw australia dietary intake mothers children measured using food frequency questionnaires diet quality vegetable fruit variety calculated using australian recommended food score australian child adolescent recommended food score associations maternal child diet quality variety assessed using pearson correlations total effect utero maternal pregnancy diet childhood diet decomposed direct indirect effect using mediation analysis maternal pregnancy post natal diet correlated child diet overall diet quality fruit vegetable variety mediation analyses showed indirect effect maternal pregnancy diet child diet mediated maternal post natal diet particularly fruit vegetables nutrition intervention therefore aimed improving diet quality variety mothers young children order subsequently improve eating habits offspring
similar renewable energy sources wind energy characterized low power density hence wind energy make considerable contributions world overall energy supply large wind farms offshore consisting arrays ever larger wind turbines envisioned built fluid mechanics perspective wind farms encompass turbulent flow phenomena occurring many spatial temporal scales particular interest understanding mean power extraction fluctuations wind farms scales ranging comprise wakes behind individual wind turbines motions reaching kilometers scale inherently associated atmospheric boundary layer review summarize current understanding flow phenomena particularly mean second order statistics field studies wind tunnel experiments large eddy simulations analytical modeling emphasizing relevant features wind farm design operation
children perceptions social resource inequalities investigated measuring open ended explanations race based disparities access societal resources fifth graders years years viewed animated vignettes depicting hypothetical resource inequalities institutions serving children african american european american background children frequently explained disparities terms institutions differing financial resources revealing awareness economic inequalities often underlie groups differential access societal resources children attributed inequalities differential treatment often witnessed african americans disadvantage witnessed european americans disadvantage demonstrating awareness racial minority groups likely experience restricted access resources finally children reasoned differential treatment judged inequality actions perpetuated inequality negatively children attributed inequalities institutions differing needs revealing link awareness discrimination rejection social inequalities elsevier inc rights reserved
article describes double action hydraulic power take wave energy converter inverse pendulum power take converts slow irregular reciprocating wave motions relatively smooth fast rotation electrical generator design double action power take control critical magnitude continuity generated power interaction power take behavior wave energy converter hydrodynamic characteristics complex therefore time domain simulation study presented parts included power take modeled using amesim hydrodynamic equations implemented matlab simulation used predict behavior complete system simulation results show design double action hydraulic power take wave energy converter inverse pendulum entirely feasibility superiority verified preliminary experiments especially compared existing single action power take system
introduction preoperative information bladder wall injection botulinum toxin botox holds several essential facts understand retain patients aim study review essential preoperative information items according genulf medical experts method prospective review december april three delphi rounds done survey monkey software initial questionnaire composed items patient information sheet edited genulf item rated medical expert numeric scale importance patient information last round asked experts confirm items eventually selected results list items regarded essentials patient information checked experts three delphi rounds confirmed experts best rated items learning self catheterisation essential mean interest number rate kidney protected long term mean interest number rate efficiency months long mean interest number rate discrepancies mostly lack distinction neurologic non neurologic patients conclusion identified accurate items considered essential preoperative information patients bladder wall injection botulinum toxin botox delphi method recommended elsevier masson sas rights reserved
adsorption cooling organic rankine cycle orc systems promising technologies used exploit abundant amount low grade heat sources solar energy geothermal energy waste heat industrial processes study two bed adsorption cooling cycle integrated orc simultaneously generate cooling power utilising aqsoa sapo water silica gel water adsorption working pairs rfa rmfc orc working fluids four different scenarios integrated adsorption orc system investigated first three scenarios adsorption system set topping system orc set bottoming system first one utilized waste heat adsorption power orc system additional heat named adsorption heat recovery scenario ahrs second scenario adsorption return heating fluid used power orc system return adsorption heating fluid scenario rahfs third scenario heat exchanger scenario hes cooling heating sources leaving adsorption system enter heat exchanger additional heat added cooling fluid order power orc system fourth scenario return orc heating fluid scenario rorchfs orc considered topping system adsorption system considered bottoming system return orc heating fluid used power adsorption cycle results show using ahrs integrated adsorption orc system achieved system efficiency using silica gel water using sapo water addition maximum specific power specific cooling power scp achieved utilising sapo values ads ads respectively work highlights potential using integrated adsorption cooling system orc generate cooling power simultaneously elsevier ltd rights reserved
control tilt twist angles ion implantation process becoming one challenging issue future cmos technologies continuous shrink cmos device dimensions imposes accurate dopant placement within transistor architecture moreover improvement packing density increases shadowing impact resist patterns leading use quasi vertical implants paper propose experimentally determine sensitivity standard electrical parameters advanced technologies sub mum tilt angle variations may occur within wafer within lot lot lot critical implants high tilt implants pockets studied pmos nmos transistors nominal results obtained nominal tilt angle compared electrical results threshold voltage law short channel effects obtained modified tilt angle degrees curves sensitivity extracted conclusion specifications angle accuracy proposed order insure perfect matching device performance whatever tilt angle discrepancies
photocatalytic hydrogen evolution potential route converting inexhaustible solar energy available clean chemical energy herein highly efficient stable tio photocatalysts hydrogen generation prepared incorporating clusters onto surface tio facile precipitation method obtained tio photocatalyst optimal content mol shows outstanding photocatalytic production rate mol apparent quantum efficiency comparable excellent tio photocatalyst efficient copper specie modified tio photocatalyst formation clusters essentially contribute enhanced production activity reducing potential water reduction promoting transfer photogenerated electrons conduction band tio clusters high stability tio photocatalyst achieved due oxidation process structure confinement clusters mesopores tio work brings new insight developing low cost noble metal free photocatalytic system solar fuel conversion elsevier rights reserved
quercetin flavonoid high antioxidant activity conceivably useful pharmaceutical cosmetic applications additionally molecular structure potentially suited stabilize emulsions work interaction quercetin cationic nonionic surfactants mixed surfactant bioactive nanoemulsion investigated high loaded quercetin nanoemulsion prepared wow entrapment efficiency prepared sub pit method assessed terms thermal photostability safety cosmetic applications proved highly stable chemical degradation ambient sub ambient storage conditions photostable artificial radiation results absorption emission spectroscopy differential scanning calorimetry confocal fluorescence microscopy studies showed nanoemulsion quercetin appears mainly form neutral non emissive hydrogen bonded tautomer minor population emissive hydrogen bonded tautomer mono anionic form quercetin stable radiation iii quercetin interacts surfactants predominantly located oil water interface nanodroplets contrast present coarse emulsion quercetin preferentially dispersed aqueous phase nanoemulsion showed excellent biocompatibility skin low eye irritancy potential het cam assay favorable safety profile coupled high antioxidant content thermal photophysical stability suggests large potential quercetin nanoemulsion studied work skin care applications elsevier rights reserved
economics information security recently become rapidly growing field research vitally important managing decisions behaviors cyberspace security field provides valuable insights security experts also policy makers business managers economists psychologists paper going discuss emergence evolution economics information security came today future directions research conducted survey explores literature economic issues information security review advantages drawbacks future research directions set scene assessment analysis economics information security publications followed furthermore provide structured discussion overview selected sets works highlight models theories field organizing presented works six main categories namely information security investment trust privacy network security malicious program malware economics penetration testing digital forensics software security additionally survey aims familiarize readers major areas field already hand indicate gaps overlooked issues economics security
backgroundschool based treatment counseling services tcss integrate mind body techniques mbts improve children health wellness academic performance aimed describe effect school based tcs mbt use among students experiencing difficulties concentration emotions behaviors getting along dcebg methodsnational health interview survey data utilized logistic regression examined associations tcs type mbt use propensity score matching controlled confounders prematch sample resultscompared children without dcebg mbt use higher among children dcebg decreased receipt school based tcs increased receipt school tcs compared nonschool tcs associated lower mbt use matching difference remained prematch postmatch prematch postmatch school tcs use increased family activity limitations decreased higher parental education mind body techniques use higher girls associated higher parental education family activity limitations conclusionswhile relative increase mbt integration school based tcs commendable encouraged school mental health practitioners account differential effects family level factors tcs choice mbt use
paper presents novel relational database architecture aimed visual objects classification retrieval framework based bag features image representation model combined support vector machine classification integrated microsoft sql server database
considered process density wave propagation logistic equation diffusion fisher kolmogorov equation arguments deviation firstly studied local properties solutions corresponding considered equation periodic boundary conditions using asymptotic methods shown increasing period makes spatial structure stable solutions complicated secondly performed numerical analysis particular considered problem propagating density waves interaction infinite interval numerical analysis propagating waves interaction process described equation performed computing cluster yarsu usage parallel computing technology openmp computations showed complex spatially inhomogeneous structure occurring interaction waves explained properties corresponding periodic boundary value problem solutions increasing spatial variable changes interval thus complication wave structure problem associated space extension
despite enormous empirical success formalism quantum theory still raises fundamental questions nature described terms complex hilbert spaces modifications could reasonably expect find regimes physics address questions studying compatibility thermodynamics constrains structure quantum theory employ two postulates probabilistic theory reasonable thermodynamic behaviour arguably satisfy framework generalised probabilistic theories show postulates already imply important aspects quantum theory like self duality analogues projective measurements subspaces eigenvalues however may still admit class theories beyond quantum mechanics using thought experiment von neumann show theories admit consistent thermodynamic notion entropy prove second law holds projective measurements mixing procedures furthermore study additional entropy like quantities based measurement probabilities convex decomposition probabilities uncover relation one quantities sorkin notion higher order interference
purpose review review current studies cannabinoids urinary bladder cannabinoids identified urinary bladder purported play modulatory role detrusor overactivity change expression cannabinoid receptors cbr patients compared healthy controls studies using knock mice suggest sensory urodynamic endpoints modified activation cbr clinical studies demonstrated cannabis improves urgency patients neurogenic cbr involved micturition peripheral cns sites cbr expressed afferent fibre endings urothelium could influence bladder function cbr agonists may useful future treatment altered cbr expression bladders addition faah localised human bladder future studies may show enzyme role bladder dysfunction
two omnidirectional circularly polarized low gain antennas crossed drooping dipole mode circular patch antenna developed direct broadcast satellite radio dbsr outdoor mobile terminal applications two medium gain circularly polarized microstrip patch arrays one uses conventional circular polarization feed uses sequentially arranged feed techniques also developed provide least dbic peak gain dbsr indoor fixed terminal applications sequentially arranged fed array better performance broader bandwidth conventionally fed array antennas small size mass inexpensive fabrication cost patch antennas also low profile john wiley sons inc
buprenorphine partial agonist kappa antagonist used treatment pain opioid addiction mixture buprenorphine hydrochloride naloxone hydrochloride approved treatment opioid dependence study third order derivative spectrophotometric method based zero crossing technique used simultaneous determination buprenorphine hydrochloride naloxone hydrochloride tablets measurements carried wavelengths zero crossing point naloxone hydrochloride zero crossing point buprenorphice hydrochloride buprenorphine hydrochloride naloxone hydrochloride respectively third order derivative spectra obtained methanol naoh solvent method found linear range buprenorphine hydrochloride naloxone hydrochloride within day day coefficient variation error values less respectively proposed method successfully used simultaneous determination drugs pharmaceutical dosage form without interference excipients need prior separation analysis
background clinical data long term safety efficacy infliximab psoriatic patients older years limited objectives aim report long term efficacy safety tolerance infliximab geriatric patients methods retrospective study conducted department dermatology university rome tor vergata clinical data reported week results charts evaluated total patients included range age years mean age years female male ratio mean age onset psoriasis years average treatment duration months range fourteen patients suffered plaque type psoriasis psoriatic arthritis baseline mean pasi score week mean pasi respectively reduction mean pasi maintained long term treatment patients conclusion data suggest long term treatment infliximab effective safe patients years old therapy also associated high compliance
study presents design channel field programmable gate arrays fpga ultrasound instruments working high frame rates order fps fpga multiline acquisition ethernet framing received data stream analog digital converters adcs study also presents implementation innovative methods moving window algorithm critical window capture envelope detection fpga data rate reduction aid video processing laptops fpga serial peripheral interfacing bus interface towards microcontroller fpga also data interface towards adcs gigabit ethernet mac device microcontroller line management interface gigabit ethernet mac fpga fpga dataflow consists received signal processing captured ultrasound data adcs temporary storage fpga forwarding external ethernet devices ethernet framing functional blocks integrated synchronized external clock internal clock control signal generation modules generate requisite timing clocks fpga design realized prototype hardware prototype hardware microcontroller based control matlab based graphical user interface device configurations image processing captured packets well acquired image results shown design modular flexible large scale integration cost effective easily replicated
aim assess impact disease characteristics quality life qol children inflammatory bowel diseases ibd methods cross sectional study conducted first department pediatrics university athens aghia sophia children hospital children diagnosed crohn disease ulcerative colitis followed outpatients hospitalization participated informed consent obtained legal representative qol assessed impact iii questionnaire demographic data disease characteristics also collected statistical analyses included parametric student test pearson non parametric mann whitney test fisher test spearman rho procedures results ninety nine patients females females aged years included overall well sub domain scores differ overall score respectively entire sample total score related physician global assessment pga patients classified mild moderate active disease average points lower total scores compared remission age impact completion pearson disease activity assessed indices pediatric ulcerative colitis activity index pediatric crohn disease activity index pga significantly associated subdomains scores presence extraintestinal manifestations negative impact emotional social functioning domains conclusion disease activity main correlate qol children ibd underlining importance achieving sustaining clinical remission key words inflammatory
background translation knowledge skills classroom settings clinical practice major challenge healthcare training especially behavioral interventions example screening brief intervention referral treatment sbirt highly promoted approach identifying treating individuals risk alcohol drug problems yet effective routine use sbirt lagged objective objective paper describe development pilot testing trial protocol mobile app based theory planned behavior tpb promote sbirt skill translation application methods intended use classroom training occurs mobile app three primary functions designed increase behavioral intent deliver sbirt review skills address knowledge beliefs sbirt apply skills patients build confidence perceived behavioral control report performance data increase accountability social norms influence app includes depression anxiety screening tools due high comorbidity substance use randomized controlled trial rct progress among health social service learners recruited universities different training programs nursing social work internal medicine psychiatry psychology participants randomized sbirt classroom instruction alone classroom instruction plus app access prior beginning field placement rotations tpb based data collected via qualtrics via mobile app pre post sbirt utilization weekly weeks key outcomes include frequency self reported confidence delivery sbirt results beta testing advanced practice nursing students indicated app associated assessment tools acceptable useful system usability scale sus mean indicated sbirt app acceptable could benefit improvement indeed modifications implemented prior starting trial enrollment trial participants began september results expected december conclusions report describes process tpb based app development testing protocol rct determine effectiveness app enhancing skill translation effective approach could improve sbirt implementation fidelity clinical outcomes
background objective previous studies suggest migraine might associated female sexual dysfunction fsd although association may complicated overweight obesity disentangle relationships migraine obesity fsd examined fsd rates women migraine obesity matched sample women obesity free migraine associations indices migraine severity fsd larger sample participants migraine overweight obesity controlling important confounders methods women migraine obesity seeking behavioral weight loss treatment decrease headaches nonmigraine controls obesity seeking weight loss via bariatric surgery matched age years body mass index bmi reported sexual activity past month groups completed female sexual function index fsfi validated fsfi total cutoff score used define fsd participants migraine overweight obesity separate logistic regression models evaluated associations migraine attack frequency intensity duration odds fsd controlling age bmi depression anxiety results average participants matched controls severe obesity bmi range years age range fsd rate differ migraine participants controls larger sample participants migraine overweight obesity years age bmi range migraine days month maximum pain intensity scale average attack duration hours fsd associated attack frequency pain intensity attack duration associated severe anxiety symptoms conclusions rates sexual dysfunction differ severely obese women without migraine moreover indices migraine severity associated increased risk fsd women overweight obesity replication present findings wider populations women migraine normal weight overweight obese status warranted
lately upsurge interest compressed data structures aiming pack ever larger quantities information constrained memory without sacrificing efficiency standard operations like random access search update main goal paper demonstrate data compression benefit networking community showing squeeze forwarding information base fib giant table consulted routers make forwarding decisions information theoretical entropy bounds essentially zero cost longest prefix match fib update first adopt state art compressed data structures yielding static entropy compressed fib representation asymptotically optimal lookup redesign venerable prefix tree used commonly lookup least years routers also admit entropy bounds support lookup optimal time update nearly optimal time evaluations linux kernel prototype indicate compressors encode fib comprising prefixes memory threefold increase lookup throughput penalty fib updates
article places media violence research broader context typical public debate whether violent video games programs movies cause school shootings extreme acts violence describe scientists today decide whether one variable exposure violent media increases risks contributes causes another aggressive violent behavior discuss different research methods used examine relationship exposure violent media aggressive violent acts review research evidence link exposure violent media aggressive behavior violent behavior undesirable behavior less helping less empathy compassion others conclude although exposure violent media cause aggressive violent behavior important risk factor contribute aggressive violent behaviors fewer prosocial behaviors
mild diaper dermatitis often occurs children toilet training complete particularly months age common presentation irritant contact dermatitis diaper dermatitis may account dermatology visits health care providers first year life fortunately since introduction hypoallergenic superabsorbent modern disposable diapers incidence severity irritant allergic contact dermatitis decreased dramatically diaper dermatitis broadly refers skin disorders occur diaper area skin eruptions triggered diapers rashes exacerbated diaper events occur diaper area number skin conditions occur anywhere skin may present distinctive findings diaper area following discussion review common triggers diaper dermatitis contact irritant dermatitis focusing skin conditions may associated overlap clinically contact dermatitis
high sided lightly loaded vehicles known prone accidents strong gusty winds wind related accidents may occur anywhere roads vehicles sensitive wind passing bridges given higher road elevations exposure possible speed effects various bridge locations compared ground level roads paper presents extended roll model estimation vehicle stability strong gusty winds study example double deck suspension bridge four typical vehicles investigated including tractor trailer truck intercity bus courier van full sized suv using sectional model bridge deck vehicle models built scale six component force moment coefficients measured various lanes full azimuth wind directions effects road level also investigated based expected wind turbulence properties bridge site measurements wind flow modifications various deck locations vehicle stability roll predicted various wind vehicle speeds calibration purposes comparative tests analyses vehicles carried confederation bridge pei canada results compared adopted policy traffic control strong winds bridge recommendations traffic management strong winds tested bridges drawn
immersive multi user virtual environments give good support closely coupled collaboration located users complex collaborative tasks may require individual user navigation achieve loosely coupled collaboration designed navigation framework based human joystick metaphor alterations cohabitation management model allows user navigate independently using human joystick based control avoiding physical obstacles staying within usable part system conducted series user studies investigate influence alteration testing combinations various navigation tasks results show modified transfer functions adaptive neutral orientations improve users cohabitation performance impact adaptive neutral positions need studied
understanding acceptance electric mobility typically discussed comparison vehicles different types propulsion engines battery electric vehicles vehicles internal combustion engine nevertheless electric mobility comprehends combination public transport electric vehicles aim paper understand peoples outlook electric mobility identifying shared aspects assessment battery electric vehicles different user perspectives transportation special research design form repertory grids provides opportunity study underlying causes cognitive perceptions emotions relating electric mobility cognitive interviews motivate respondents reflect beyond insights provided standard forms interview especially topic battery electric vehicles prejudices instance propagated media discarded actual requirements patterns mobility become visible special tasks involved interviews lead example deliberation integrate battery charging processes existing mobility patterns special method reveals individuals take interest characteristics modes transport usually analysed researching electric mobility addition three anticipation clusters identified individuals higher affinity cars first perception battery electric vehicles shows high levels similarity cars internal combustion engines differentiating types engines meaningless second battery electric vehicles perceived part urban public transport third battery electric vehicles viewed similar pedelecs seg ways whereas questions range innovation environmental aspects play greater role perceptions results lead conclusion studying acceptance bevs comparison cars internal combustion engines battery electric vehicles sufficient grasp complete user perspective analysis within framework wider range modes transport required order address people transportation needs elsevier ltd rights reserved
micro gas turbines mgts offer valuable advantages small scale combined heat power chp production compared reciprocating internal combustion engines ices lower maintenance costs per kwh cleaner exhaust lower vibration levels concentration residual heat single source exhaust gases nevertheless mgts lower electrical efficiencies fact prevented penetrating chp market hot liquid water injection means saturation tower within micro humid air turbine mhat cycle allows improving flexibility heat production electrical efficiency mgts two qualities enhanced would increase economic feasibility technology although advantages mhat technology proven thermodynamic point view economic performance yet fully investigated paper presents comparison economic profitability primary energy savings mgt ice mhat unit operating real network conditions aim investigate whether increase flexibility electrical efficiency achieved transforming mgt mhat allows technology economically outperform ices results show three units viable scenarios high electricity low natural gas prices cases investment feasible revenues mhat highest thanks flexibility heat generation mhat units able run year long hand greatest primary energy savings achieved ice units highest overall efficiencies mhat savings substantially lower elsevier ltd rights reserved
basis initio simulations value strength interatomic bonds one two three dimensional carbon crystals obtained shown decreasing dimensionality crystal gives rise nearly linear increase strength atomic bonds ascertained growth strength crystal decrease dimensionality due reduction coordination number atom increase angle directions atomic bonds based data substantiated one dimensional crystals maximum strength strength carbyne absolute upper limit strength materials
ubiquitous computing ubicomp term used human interaction computers virtually everything almost everywhere embedding computers daily lives create active intelligent environment future phase computers beyond desktop notebook environment currently progressively heading deeper inside new phase ubiquitous computing mainly focus computer integral part human unaware presence computer scientists focusing hard ways interaction human computer simplified think era surrounded hundreds computers unique task irrespective location time keeping human unaware article explore evolution ubiquitous computing origin history architecture role privacy integration privacy system design features technical challenges ubiquitous computing third wave computing begun ubicomp field require considerable efforts match current technological developments according view computer scientists engineers future technological advancement field amaze world
purpose nocturia sleep problems common older adults developed tested novel intervention multicomponent behavioral treatment exercise therapy bet may reduce nocturia improve sleep men compared reductions nocturia improvement sleep men bet versus active drug comparator alpha blocker used alone combination bet alpha blocker methods randomized controlled trial conducted ambulatory setting department veterans affairs medical centers men least years age nocturia defined nightly episodes participants randomized receive either bet including pelvic floor muscle training urge suppression techniques delayed voiding fluid management sleep hygiene peripheral edema management active comparator known efficacy alpha blocker tamsulosin one tablet nightly therapies combined participants received interventions weeks outcomes assessed via voiding diaries wrist actigraphy validated questionnaires primary outcome change diary recorded nocturia assessed using ancova group changes paired tests within group changes findings total men mean age years participated weeks mean diary recorded nocturia changed bet episodes night alpha blocker therapy episodes night combination therapy episodes night reductions statistically different across treatment groups bet also showed statistically significant improvements sleep quality bother nocturia nocturia specific quality life treatment groups indicated global satisfaction treatment implications behavioral therapy men alone combined blocker therapy consistently showed large statistically significant nocturia reductions favorable effects sleep quality life based findings behavioral therapy statistically superior alpha blocker therapy may provide meaningful treatment option men nocturia future research include development behavioral treatment exercise therapy interventions could easily deployed published elsevier journals inc
remote sensing image processing traditional fusion algorithm based intensity hue saturation ihs transformation method take account texture spectrum information spatial resolution statistical information photos adequately leads spectrum distortion image although traditional solutions application combine manifold methods fusion procedure rather complicated suitable practical operation paper improved ihs transformation fusion algorithm based local variance weighting scheme proposed remote sensing images proposal firstly local variance spot comes french systeme probatoire observation dela tarre means earth observing system image calculated using different sliding windows optimal window size selected images normalized optimal window local variance secondly power exponent chosen mapping function local variance used obtain weight component match spot images obtain component weight component matched spot images finally final fusion image obtained inverse intensity hue saturation transformation components proposed algorithm tested compared image fusion methods well known literature simulation result indicates proposed algorithm could obtain superior fused image based quantitative fusion evaluation indices
lacking shelter care children chinese lost child elderly impoverished mental state compared older people general fragile sensitive even united self help efforts often unhelpful scale increasingly expanding risen many serious social problems appearance lost child old man people vulnerability protection elderly mainly due faultiness birth control policy lack government finance imperfect social security system chinese government establish mechanism increase maintain value administrative compensations strengthen administrative pay protection administrative contracts broaden administrative relief channels elderly effectively protect pension interests lost child elderly
background previous research suggests exposure nicotine replacement therapy nrt may associated increased risk cardiovascular disease cvd methods using data united kingdom clinical practice research datalink study aimed evaluate cvd events survival among individuals attempted smoking cessation support nrt compared aided smoking cessation advice studied cvd outcomes weeks smokers attempting quit supported smoking cessation advice support nrt prescribed primary care physician patients matched smoking cessation advice patients nrt patient demographic clinical characteristics baseline year preceding quit attempt cox proportional hazard regression conditional negative binomial regression model conditional logistic regression used analyze data results mean standard deviation population age years females time first diagnosis ischemic heart disease ihd among nrt smoking cessation advice patients similar within first weeks shorter nrt patients weeks hazard ratio confidence interval similar trend observed cerebrovascular disease nrt patients prior diagnosis ihd cerebrovascular disease higher rate primary secondary care consultations ihd cerebrovascular disease weeks rate ratio patients prescribed nrt shorter survival time weeks compared receiving advice conclusion findings suggest treatment nrt weeks appear impact cardiovascular risks however longer follow period weeks resulted increase cardiovascular events patients prescribed nrt compared receiving smoking cessation advice
verifying complex systems power plants satisfy requirements ensure proper operation particular respect safety dependability environmental regulations difficult due large number potential situations explored terms initiating events chain consequences behavior system paper presents new framework supporting methodology aims reconciling innovation ability modify system safety ability comply regulatory requirements general principle produce independently formal models requirements possible variants design dynamic behavior system possible designs assemble together simulate full system behavior automatically detect possible violations requirements
results meta analyses suggested subtle deficits cognitive control among antisocial individuals almost studies focused children conduct problems adult psychopaths however little known cognitive control mechanisms among majority persistent violent offenders present antisocial personality disorder aspd present study aimed determine whether offenders aspd relative non offenders display dysfunction neural mechanisms underlying cognitive control assess extent dysfunctions associated psychopathic traits trait impulsivity participants comprised violent offenders non offenders underwent event related functional magnetic resonance imaging performing non verbal stroop task offenders relative non offenders exhibited reduced response time interference different pattern conflict error related activity brain areas involved cognitive control attention language emotion processing anterior cingulate dorsolateral prefrontal superior temporal postcentral cortices putamen thalamus amygdala moreover group differences behavioural neural responses revealed associations core features psychopathy attentional impulsivity thus results present study confirmed hypothesis offenders aspd display alterations neural mechanisms underlying cognitive control alterations relate least inpart personality characteristics published elsevier ireland ltd
intuitionistic fuzzy databases used handle imprecise uncertain data represent membership nonmembership hesitancy associated certain element set paper presents intuitionistic fuzzy fourth normal form decompose multivalued dependent data technique determine intuitionistic fuzzy multivalued dependencies working closure dependencies proposed derive closure obtaining logically implied dependencies set intuitionistic fuzzy multivalued dependencies inference rules complete set inference rules intuitionistic fuzzy multivalued dependencies given along derivation rule rules help compute dependency closure use defining intuitionistic fuzzy fourth normal form
novel folded cascode operational amplifier opamp employing nested gain boosted technique presented gain booster signal path consists two level recursive folded cascode amplifier achieve high gain high speed opamp designed simulated cmos technology bode plot results open loop gain unity gain frequency loads obtained settling measurements shows opamp settling time less proposed opamp employed high speed high resolution analog digital converters adcs pipelined adc
facile sol gel method suggested prepare tio zno photocatalysts nanocomposites tio zno prepared different amounts zinc oxide precursors prepared products characterised xrd raman vis drs tem edx bet eis techniques photocatalytic response tio zno nanocomposites analysed degradation organic dyes brilliant green methylene blue solar light irradiation outcome increased surface area rod like morphology low charge transfer resistance reduced band gap composite tio zno optimum level zinc sulphur contents showed enhanced photocatalytic activity degrading dyes
static dynamic characteristics practicable step nine switch matrix convertor control strategy proposed venturini analysed fully recently presented circuit transformation technique signal flow graphs step nine switch matrix convertor consists nonideal voltage current sources occur practical inductance capacitance filters energy storage elements inductors capacitors simplified ideal current voltage sources previous works dynamic behaviour convertor explored several static dynamic features convertor steady state input output voltage gain input power factor transient response predicted analytically verified computer simulations signal flow graph adopted solve complex fourth order equivalent convertor thus nine switch matrix convertor analysed fully explicit form found voltage gain input displacement angle independently controllable unlike ideal nine switch matrix convertor case however controllable certain extent properly selected switch modulation function paper compares computer simulation results obtained analytic technique authors expect report practical circuit work due course
small noncoding rnas sncrnas play important roles rna interference rnai addition microrna mirna piwi interacting rna pirna one key member sncrnas group endogenous small interfering rna endo sirna studies show role endo sirnas dicer ago mutants however biological functions specific endo sirnas remains mostly unanswered study performed comparative analysis endo sirnas present porcine sperms oocytes zygotes identified deep sequencing bioinformatics analysis observe large amount endo sirnas specific binding orf utr porcine sirnas sirnas generated dsrna formed transcript newly identified antisense noncoding rna characterized show sirnas regulate early embryonic development inhibiting activity retrotransposition work contribute understanding functional role abundant endo sirnas embryonic development
autonomous mobile service robots move buildings carrying different tasks across multiple floors moving performing tasks robots find variety states although speech often used communicating robot state humans communication often ineffective investigate use lights persistent visualization robot state relation tasks environmental factors programmable lights offer large degree choices terms animation pattern color speed present space choices introduce different animation profiles consider animate set programmable lights robot conduct experiments query suitable animations three representative scenarios autonomous symbiotic robot cobot ourwork enables cobot tomake state persistently visible humans
context optimism around antiretroviral therapy art prevention hiv aids addressing barriers long term art adherence critical particularly important given tendency individualise use blame discourse exploring hiv infected patients fail adequately adhere art sufficiently exploring contextual reasons poor adherence may require varying solutions study took place three clinics one hospital khayelitsha south africa document contextual factors challenged art adherence community interviews conducted hiv infected patients defaulted art subsequently admitted khayelitsha hospital clinical complications art service providers including doctors nurses hiv counsellors interviews assessed reasons patients defaulted art explored ways could prevented data groups analysed collectively using thematic analysis interviews revealed landscape environmental risks threatening adherence art patients managed overcome identified barriers point treatment phase indicating fluidity patients needs decision making patients reported distrustful relationships service providers could inhibit understanding art interrupt follow clinics patients described rationale agency underlying non adherence testing bodies physical limits without art medication study speaks need appreciate contextual social structural barriers related art adherence negotiated differently specific sub groups support appropriate response imperative solely emphasise loss follow also assess patients subjective trajectory art journey decision making agency adhering art relations healthcare workers dynamics intertwined broader constraints health systems
ankylosing spondylitis chronic inflammatory disease primarily affecting sacroiliac joints spine pathogenesis thought result combination host genetic factors environmental triggers however precise factors determine one susceptibility remain unraveled trillion bacteria residing mammalian gut established symbiotic relation host influencing many aspects host metabolism physiology immunity growing body evidence suggests intestinal microbiota may play important role several mechanisms suggested explain potential role microbiome etiology alterations intestinal permeability stimulation immune responses molecular mimicry review existing evidence involvement microbiome pathogenesis discussed potential intestinal microbiome targeting strategies prevention treatment evaluated
global increase cultural religious diversity led calls toleration group differences achieve intergroup harmony although much social psychological research examined nature stereotyping prejudice discrimination impact targets biases little research examined nature impact toleration intergroup relations toleration require people give objections group norms practices rather mutual accommodation integrating research various social sciences explore nature intergroup tolerance including three components objection acceptance rejection drawing implications future social psychological research explore psychological consequences social groups object toleration consider complex ways intergroup tolerance impacts majority minority groups dynamic interplay pluralistic societies
paper presents eso based ipi control common rail pressure first detailed mathematical model high pressure common rail injection system hpcris built mathematical model validated software matlab commercial software amesim considered hpcris effective model free controller called extended state observer based intelligent proportional integral eso based ipi controller designed proposed eso ipi controller composed mainly referred eso observer ipi controller finally demonstrate performances effectiveness proposed controller proposed controller implemented compared conventional pid controller active disturbance rejection control adrc corresponding simulations carried
mathematical model linear induction motor energy flow relationship dual linear induction motor system analyzed paper basis analysis energy cross feed dual linear induction motor testing system designed cross feed dual energy linear induction motor testing system consists two linear induction motors accordance certain control strategies one electric motor state one power generation state testing systems could used simulate characteristics motor loading status motor traverse mechanical energy produced mechanical motion electrical energy backs grid testing system possesses excellent properties good reliability energy efficiency flexible control ability
forensic sciences verification digital media recordings important aspect electrical network frequency enf criterion promising technique media recording authentication enf reference database recorded single point power grid based fact enf variation across points grid fact valid case system disturbances whereas enf reference database varies time space post disturbance enf recorded single point mismatched enf extracted media recorded point grid lead judicial errors forensic examination recordings new method establishing robust enf reference database using geographical information system gis wide area frequency measurements proposed method based building enf reference database number frequency sensors deployed multipoint grid rather single point minimum number sensors required determined according frequency sensitivity enf extraction algorithm estimation accuracy frequency sensor sensors locations decided based partitioning power grid set geographical frequency coherent areas novel harmony search algorithm using gis data wide area frequency measurements proposed identify geographical frequency coherent areas different disturbance scenarios results showed proposed method used enhance accuracy enf database matching process
background prevalence oral mucosal fungal infections increases frequent administration antibiotics corticosteroids immunosuppressive drugs therapeutically used antifungals usually associated variety drug interactions furthermore noticeable increase microorganisms resistant preparations mucoadhesive buccal films represent modern therapeutic system treatment oral mucosal fungal infection paired high degree patient compliance ciclopirox olamine applied directly onto oral mucosa offers attractive alternative treatment systemic antifungals thanks low incidence resistance side effects objective aim work evaluate pharmacokinetic parameters ciclopirox olamine buccal application mucoadhesive film prepared solvent casting method method chromatographic method using internal standard developed validated evaluation ciclopirox olamine plasma concentrations method accuracy interday intraday assays respectively results pharmacokinetic properties ciclopirox olamine studied new zealand white rabbits mucoadhesive films containing ciclopirox olamine total dose applied rabbits plasma ciclopirox olamine concentrations determined following application time taken reach maximum plasma concentration drug administration cmax overall elimination half life conclusion experiment suggests oral mucoadhesive film may valuable alternative ciclopirox olamine administration
purpose paper introduce new trajectory tracking controller applied furuta pendulum arm tracks desired time varying trajectory pendulum remains regulated upward position controller derived input output feedback linearization technique rigorous analysis internal dynamics presented showing tracking error regulation error trajectories uniformly ultimately bounded experimental results show validity introduced theory additionally detailed experimental study also presented pid controller output tracking controller compared respect new algorithm presents best performance
objective despite early dietary treatment phenylketonuria patients lower poorer executive functions compared healthy controls cognitive problems phenylketonuria often associated phenylalanine levels present study examined cognitive profile mental health adult phenylketonuria relation phenylalanine levels tetrahydrobiopterin treatment method fifty seven early treated adult patients phenylketonuria healthy matched controls years performed subtests executive function tests amsterdam neuropsychological tasks also completed adult self report mental health problems analyses variance performed examine group differences results patients phenylketonuria normal iqs although lower controls performed poorer working memory inhibitory control sustained attention tasks patients reported depressive avoidant personality problems frequently specifically patients childhood lifetime phenylalanine mol poorer cognitive mental health outcomes controls subset patients comparisons patients tetrahydrobiopterin showed nontetrahydrobiopterin users matched childhood pretreatment phenylalanine slower number tasks reported mental health problems conclusions adult patients lower poorer executive functions controls resembling problems observed younger patients phenylketonuria well internalizing problems group differences phenylalanine outcome associations smaller observed younger populations subset nontetrahydrobiopterin users matched childhood phenylalanine level poorer outcome tests tetrahydrobiopterin users might indicate impact tetrahydrobiopterin treatment beyond lowering phenylalanine however clinical relevance needs investigation
objectiveto examine association year temporal changes primary care workforce medicare beneficiaries outcomes data sources american medical association masterfiles fee service medicare claims study design methodswe calculated two primary care workforce measures within primary care service areas number primary care physicians per population per capita number medicare primary care full time equivalents ftes per medicare beneficiaries three outcomes mortality ambulatory care sensitive condition acsc hospitalizations emergency department visits measured marginal association changes primary care workforce patient outcomes using poisson regression models principal findingsan increase one primary care physician per population associated fewer deaths per fewer acsc hospitalizations per increase one medicare primary care fte per beneficiaries associated fewer deaths per fewer acsc hospitalizations per fewer visits per conclusionsmedicare beneficiaries outcomes improved number primary care physicians clinical effort increased
computer programming courses aim develop students programing skills problem solving abilities easily achieved traditional teaching method focuses boring grammar approach thinking students learn deeper article practiced deep learning cycle delc curriculum programming language steps delc focused step processing learning deeper adopted task based mode online judge like acm icpc designed problem repository teaching contents closely combined make students learn deeper practice proved based delc teaching model students programming skills proficiency greatly improved
evidence emotional expressions characterized diagnostic cues individual face features example upturned mouth indicative happiness whereas furrowed brow associated anger current investigation explored whether motivating people perceive stimuli local feature based rather global holistic processing orientation advantageous recognizing emotional facial expressions participants classified emotional faces primed local global processing orientations via navon letter task contrary previous findings identity recognition current findings indicative modest advantage face emotion recognition conditions local processing orientation primed local processing orientation participants performed significantly faster accurately emotion recognition task primed global processing orientation impacts finding theories emotion recognition face processing considered
one challenging aspects accurate simulation three dimensional soft objects vesicles biological cells computation membrane bending forces origin difficulty stems need numerically evaluate fourth order derivative discretized surface geometry investigate six different algorithms compute membrane bending forces including regularly used methods well novel ones based physical model due canham helfrich start surface discretization flat triangles time differ substantially numerical approach start comparing numerically obtained mean curvature laplace beltrami operator mean curvature finally surface force density analytical results discocyte resting shape red blood cell find none considered algorithms converges zero error nodes algorithms error even diverges furthermore pronounced influence mesh structure discretizations irregular triangles node connectivity present serious difficulties investigated methods assess behavior algorithms realistic physical application investigate deformation initially spherical capsule linear shear flow small reynolds numbers exclude influence flow solver two conceptually different solvers employed lattice boltzmann boundary integral method despite largely different quality bending algorithms applied static red blood cell find actual flow situation algorithms give consistent results hydrodynamic solvers even short review earlier works reveals wide scattering reported results taylor deformation parameter besides presented application biofluidic systems investigated algorithms also high relevance computer graphics numerical mathematics communities elsevier rights reserved
mcs lock one prevalent queuing locks provides fair scheduling high performance massively parallel systems however mcs lock mandates bring context policy lock user must provide additional context queue node interact lock paper proposes mcsg variant mcs lock relaxes restriction key observation lock users created equal analyzed locks used massively parallel modern systems numa aware operating systems databases found systems often small number regular code paths enter lock frequently code paths primary beneficiary high scalability mcs locks however also many guest code paths infrequently enter lock need degree fairness access lock background tasks run periodically lower priority guest users typically spread various modules software prefer context free locks ticket locks mcsg provides guests context free interface regular users still enjoy benefits provided mcs also used drop replacement mcs advanced locks cohort locking also propose mcsg extended version mcsg avoids guest starvation non fifo behaviors might happen mcsg evaluation using microbenchmarks tpc database benchmark socket core server shows mcsg mcsg preserve benefits mcs regular users providing context free interface guests
roller one main parts high pressure grinding roller type highly efficient ore crushing equipment working life strongly affected materials used paper new kind roller material high vanadium alloy steel hvas investigated results showed cast microstructures hvas roller contained martensite residual austenite alloy carbides hvas sample quenched degrees high hardness much higher compressive strength abrasive wear resistance tempering degrees min mechanical properties hvas sufficient existing roller materials feasible larger machine design
paper describes concept software tools data stream processing tools used implement parallel processing systems description task presented first part paper system based pipeline parallelism distributed using cluster computer paper describes base scheme main work algorithm system actual application example presented system weak sides described end paper direction future research presented end article
recently reported piwi interacting rnas likes pir could regulate functions interacting phosphorylated proteins proteins addition except writers erasers functional efficacy proteins readers still remains unknown therefore reasoned type sncrnas could regulate functional efficacy proteins profiled sncrnas interacting phosphorylated ser thr tyr residues hbe lung scc cell lines investigated effects mechanisms phosphorylated residue interacting sncrnas results demonstrated sncrnas regulating functional efficacy proteins thus referred protein functional effector sncrnas pfernas pfernas distributed among nucleotides shared core sequences showed distinctive expression patterns hbe scc cells core sequences showing consistent upregulation scc cells bound directly nucleolin ncl dependent key elements cgcg ser ncl ncl interaction critical functional efficacy ncl basic activities lung normal cancer cells thus revealed novel type pfernas controlling functional efficacy proteins lung somatic cells elsevier rights reserved
micrornas small noncoding single stranded rnas emerged important posttranscriptional regulators gene expression essential role vertebrate development different biological processes review highlights recent advances function mirnas roles bone remodeling bone diseases micrornas mirnas class small similar noncoding single stranded rnas emerged important posttranscriptional regulators gene expression essential vertebrate development play critical roles different biological processes related cell differentiation activity metabolism apoptosis rising number experimental reports indicate mirnas contribute every step osteogenesis bone homeostasis embryonic skeletal development maintenance adult bone tissue regulating growth differentiation activity different cell systems inside outside skeleton importantly emerging information animal studies suggests targeting mirnas might become attractive new therapeutic approach osteoporosis skeletal diseases even though still major concerns related potential target effects need efficient delivery methods vivo moreover besides recognized effects cellular level evidence also gathering mirnas excreted circulate blood body fluids potential paracrine endocrine functions thus could represent suitable candidates becoming sensitive disease biomarkers different pathologic conditions including skeletal disorders despite promising perspectives work remains done mirnas serve robust therapeutic targets established diagnostic tools precision medicine skeletal disorders
gene expression quantified high throughput using microarray technology describe accurately detect differential expression splicing using probe level expression change averaging peca method peca available package bioconductor https www bioconductor org supports multiple operating systems
southern nigeria leaves emilia coccinea sims dons used traditionally birth control study therefore aimed evaluating activities methanolic leaf extract emilia coccinea parameters affect reproduction well acute toxic effects plant using nonpregnant female mice models leaves extracted maceration methanol oral acute toxicity profiles examined effects female reproductive cycle determined oral treatment day daily days using stilbesterol day normal saline controls activities day day reproductive hormones organs also studied using estradiol valerat day progesterone day normal saline controls extract induce observable toxic effect extract significantly shortened estrus cycle prolonging estrus phase comparable observed stilbesterol extract also increased uterine weight altered histology uterine ovarian tissues female reproductive hormones additionally altered effects comparable estradiol valerat indicate possible antifertility effects hrftms analysis showed putatively identified compounds pyrrolizidine alkaloid occurring highest intensity among identified compounds conclusion leaf extracts shown study exhibit antiovulatory estrogenic activities would support traditional use plant nigeria
ambient intelligence systems require natural personalized experience interacting services provided environment view interaction may happen either pervasive way combination devices embedded environment using conversational interface acting environment concierge latter case interface embodied conversational agent able involve users human like conversation establish social relation developing ambient conversational system acs requires model user considers cognitive ingredients mental state also extra rational factors affect engagement attitudes paper describes multimodal framework recognizing social attitude users interaction embodied agent smart environment particular started analysis annotation advisory dialogs humans used annotated corpus build framework recognizing social attitude multimodal dialogs acs results study show acceptable performance framework recognizing monitoring social attitude dialog anacs also compared results analysis human human interactions respect human acs interaction even level initiative subjects dialog lower lattermodality difference average number social moves significant thus showing subjects probably keen establish social relation conversational agent
using data state national youth risk behavior surveys period carpenter cook find strong negative relationship cigarette taxes youth smoking revisit relationship using four extra waves yrbs data results suggest youths become much less responsive cigarette taxes since fact find little evidence negative relationship cigarette taxes youth smoking restrict attention period conclude policy makers interested reducing youth smoking may adopt alternative strategies
paper examines validity structured clinic interview dsm scid sample veterans seeking treatment substance use disorders suds participants initially receiving residential outpatient treatment suds completed scid one third participants met criteria axis disorder almost one half met criteria axis disorder concurrent discriminant predictive validity examined diagnoses suds antisocial personality disorder apd well symptoms depression anxiety thought disorder results generally provided strong support concurrent discriminant predictive validity scid diagnoses alcohol use disorders auds strong support concurrent discriminant validity drug use disorders duds mixed support concurrent validity apd predictive validity duds apd supported
users bittorrent community participate multiple swarms usually simultaneously uploader downloader thus inter swarm aspect bandwidth resource allocation high relevance algorithm design deployed bittorrent clients inter swarm connections among users bittorrent community represented flow network special structure using representation demonstrated facto solutions resource allocation bittorrent communities suboptimal paper investigate conclusion details using graph measures optimization techniques find bittorrent communities sensitive removal highly contributing users inter swarm connectivity lead different performance results torrent selection mechanisms hardly improve average download performance users regarding theoretical optimum discussed problem show necessary comply bittorrent protocol
realization millennium development goals also reflected construction industry sustainable consumption production patterns associated implementing developing reverse logistics system construction site close supply chain construction materials initiating activities undertaken already construction site conditioning thereby possibilities resource recovery stages recovery process total costs hence type quantity quality waste affect cost collection significant item project budget paper provides overview existing national recovery systems waste policies provide background case study crucial part research analysis three waste management scenarios particular construction project anthropocentric current ecocentric approaches studied terms waste collection costs two extreme approaches created alternative usual waste management policy applied construction site antropocentric approach reflection ill conceived waste management assuming segregation leads high costs waste processing ecocentric approach turn assumes direct sales sorted waste lower prices also reverse logistics within project thereby providing cost savings results show policy waste disposal encourages even forces entrepreneurs implement reverse logistics despite additional duties requirements general conclusions research confirm currently operating systems waste management site sustainable nevertheless still possible make eco efficient time profitable proved analysis ecocentric scenario could also called economic authors published elsevier ltd
deterioration models pavement surface distresses developed using probabilistic modelling approaches condition data collected using visual inspection surveys distress data used modelling include cracking texture loss stone loss different pavement surfacing types latter includes dense graded asphalt open graded asphalt ultra thin asphalt sprayed chip seal geotextile seal chip seal geotextile underlay probabilistic modelling approaches used include logistic regression markov chains two variables used modelling distress rating surface age models used network level management network modelled herein logistic models found provide predictions comparable actual average condition data different age values also observed predictions models higher predictions logistic models actual average data
myelofibrosis chronic malignancy blood forming system caused hyperactivation jak stat signaling pathway small molecule inhibitors jak variably ameliorate related symptoms caused chronic inflammation hepatosplenomegaly anemia significant problem adverse prognostic factor third patients often worsened jak inhibitors jak inhibitor momelotinib unexpectedly resulted reduction anemia patients phase trials current phase iii trials basis seeking regulatory approval momelotinib studies determine momelotinib improves anemia underway potentially leading expanded momelotinib use development targeted therapies treating anemia related diseases
background aim evaluate characteristics cardiovascular complications large belgian cohort adults diagnosed type diabetes tdm years methods retrospective analysis patients diagnosed tdm years tdm patients diagnosed age years compare variables groups independent test paired test used normally distributed continuous variables mann whitney test non normally distributed continuous variables chi squared test mcnemar test categorical variables multivariable logistic regression used adjust confounders results young onset tdm cohort age diagnosis years patients female ethnic minority background last visit age patients years diabetes duration years mean hbac mmol mol patients obese hypertensive reach ldl cholesterol target cardiac event time last visit compared women men higher hbac mmol mol mmol mol significantly higher rate cardiac events even adjustment confounders compared caucasians patients younger diagnosis years years less often obese compared first visit glycemic control improved mmol mol mmol mol time last visit compared older onset tdm cohort young onset tdm patients showed higher hbac mmol mol mmol mol higher bmi last contact adjusted age diabetes duration hbac cardiovascular risk factors difference cardiovascular events two cohorts conclusions diagnosis tdm years important impact patients lives prevention measures essential also specific attention high risk group needed better achieve therapeutic targets
sunitinib oral multi targeted tyrosine kinase inhibitor tki targets various receptors including vascular endothelial growth factor receptors vegfrs sunitinib received approval became standard treatment option first line treatment metastatic renal cell cancer mrcc phase iii trial showed superiority compared interferon alpha ifn alpha sunitinib also shown activity second line treatment several trials combination trials sunitinib various agents led considerable toxicity without improving efficacy sunitinib alone causes significant side effects distinct profile diarrhoea hypertension skin effects hypothyroidism fatigue nausea special interest recommended dose sunitinib mrcc orally daily weeks followed weeks treatment schedule alternative weeks week schedule schedule seems similar efficacy better tolerability could widely used future intermittent treatment strategy stop remission induction progression showed efficacy smaller trials currently evaluated phase iii trial direct comparison sunitinib pazopanib first line treatment showed similar efficacy tkis distinct toxicity profile data two phase trials showed sunitinib also activity non clear cell cancer option due lack better alternatives currently immune checkpoint inhibitors shown promising results second line treatment rcc tested number phase iii trials first line setting future show position sunitinib first line treatment rcc era immune checkpoint inhibitors
introduction targeted radionuclide therapy trt demonstrated effective therapeutic tool patients disseminated bone metastasis trt generally performed single radionuclide study investigated feasibility combined trt high energy beta emitter low energy beta emitter wistar rats methods cocktail complex edtmp prepared determine effect metal ligand edtmp molar ratio labeling yield several complex analyzed changing edtmp molar ratio edtmp administered intravenously tail vein wistar rats biodistribution data collected hours day post injection scintigraphic images taken hours week administration radiopharmaceutical results results revealed high skeletal uptake hours post injection respectively rapid blood clearance minimal uptake major organs scintigraphic images verified high skeletal uptake conclusion results indicate combination feasible safe study suggests combination different radionuclides different radiation energies half life could advantageous patients tumoral lesions different sizes
cutaneous lymphocyte associated antigen cla cells specialized skin homing represent main cell population atopic dermatitis lesions cla expressed surface circulating cdro memory cells skin infiltrating cells mechanistic studies thus treatment advancements limited need large number skin biopsies circulating cla cells may reliable surrogate marker inflammatory events occurring skin thus evaluation cla cells blood may eliminate need skin biopsies preliminary work established disease associated cell abnormalities approached either study skin lesions activated cla cell subsets peripheral blood future studies adults children across different skin disorders correlating blood skin phenotypes determining skin homing cell functional properties needed establish whether cla memory subsets used biomarkers substitute skin biopsies review summarizes latest advancements reached circulating cla great potential harbor understanding mechanisms
fractures second common presentation child abuse following soft tissue bruising burns often difficult determine potential abuse child presenting non rib fracture without soft tissue injuries one hundred fifteen consecutive patients aged parts per thousand currency sign years presented fracture january june emergency department pediatric fracture clinic retrospectively analyzed statistical analyses carried non accidental fractures based age year years location presentation pediatric fracture clinic type long bone fracture number fractures patient demographics fractures patients reported non accidental trauma nat eighty patients first reported thirty two percent fractures children aged year fractures children aged years reported nat sixteen patients reported abuse multiple fractures patients aged year eight reported femoral fractures transverse fractures corner fractures occurred children aged year never occurred isolation reported nat four patients commercial insurance patients medicaid reported nat age less year multiple fractures corner fractures transverse fractures covered medicaid common factors associated reporting nat
methamphetamine dependence growing problem australia globally currently approved pharmacotherapy options management methamphetamine dependence acetylcysteine one potential pharmacotherapy option received growing attention therapy managing addictions capacity restore homeostasis brain glutamate systems disrupted addiction thereby reduce craving risk relapse acetylcysteine also antioxidant properties protect methamphetamine induced toxicity may therefore assist management neuropsychiatric neurocognitive effects methamphetamine commentary overviews actions acetylcysteine evidence efficacy treating addiction particular focus potential utility methamphetamine dependence conclude preliminary evidence indicates need full scale trials definitively establish whether acetylcysteine therapeutic benefit nature benefit managing methamphetamine dependence mcketin dean baker carter turner kelly berk potential role acetylcysteine management methamphetamine dependence drug alcohol rev
background background crystal methamphetamine colloquially known tik extensively used emerging working class coloured youth cape town south africa exploratory qualitative study conducted explore experience mothers whose children use methamphetamine methods researchers conducted one one semi structured depth interviews sixteen purposively selected caregivers mothers whose sons use methamphetamine interviews recorded simultaneously translated transcribed thematic analysis used identify themes related experiences caregivers youth methamphetamine problems results findings showed youth misbehaviour provided context led feelings shame embarrassment participants also experienced personal challenges included emotional problems fear self blame participants also expressed family disruptions financial drain adverse experiences results sons misbehaviour conclusion study results highlight psychosocial challenges caregivers children use methamphetamine findings underscore need effort directed development formal support interventions mothers youth troubled addiction
waterflooding common solution enhancing oil recovery oil reservoirs water injected reservoir purpose injection rates determined optimally control desired oil production well accomplish reservoir management strategies goal achieved precisely modeling waterflooding phenomena paper applicable algorithm modeling waterflooding process oil reservoirs developed using proper system identification techniques help consider change inherent reservoir specifications addition operating point variations due injection alternation rate also severe nonlinear nature reservoir consequently obtain adaptive model reservoir able reflect mentioned phenomena reservoir considered multi input multi output mimo plant several manipulated variables outputs mimic variables dynamics reservoir operational life recursive least square rls approach utilized proper forgetting factor sliding window length selection extract reservoir dynamic model content mimo model structure developed approach evaluated spe model well known reservoir case study paper observed results demonstrate proposed method acceptable capability compared conventional line least square extended least square els approaches may lead auto regressive model exogenous input arx auto regressive moving average model exogenous inputs armax structures modeling dynamical behaviors reservoir employed powerful tool control optimization applications elsevier rights reserved
current techniques water desalination relatively costly high consumption electrical power fossil fuel desalination seawater using solar energy therefore one ways meet growing water demand low cost technologies currently available solar still fresh water production applied large scales mainly production rate desalted water low compared techniques using fossil fuels membranes low production rate main reason behind lack industrial usage solar stills maximum temperature reached within solar still high evaporation rate inside solar still remains low low temperature main reason massive disadvantage resulting reduced heat transfer rate slow vaporization process work reported herein aims analyzing reason solar still low productivity suggesting design modifications solve problem done dividing solar still evaporation four processes every process thoroughly analyzed solve main problem provide maximum temperature heat transfer rate inside solar still problem solved use solar stills industry become possibility
objective aim study compare patients antisocial personality disorder aspd healthy individuals terms sexually transmitted diseases stds blood borne transmitted infections btis prevalences methods study prospective single center open label non randomized controlled clinical study two groups study patient group consistsed males diagnosed aspd clinical interview form control group consisted healthy males psychiatric disorder dermatologic examination performed clinical findings recorded results mean age patient group range years mean age control group years common disease gonorrhea followed genital wart molluskum contagiosum hbsag hsv seropositivity patients group control group hsv seropositivity genital wart molluskum contagiosum gonorrhe commonly seen control group stds bvtis found common patients group control group conclusions patients aspd greater risk normal population catch stds btis lower educational levels riskier behaviors condition entertains risk general population patients
global industry currently facing growing increase competitiveness forces companies adopt develop new strategies methods production therefore one relevant challenges manufacturing engineering innovatively integrating product process factory dimensions life cycles holistic approach design recycling disposal reuse challenge faced synchronization simultaneous generation three domain models integrating manufacturing engineering knowledge early stage modelling planning processes next generation factories modular scalable flexible open agile knowledge based order able adapt real time continuously changing market demands technology options regulations therefore integration flexibility efficiency requirements ability simulate production life cycle factory play crucial role decreasing ramp design times furthermore play crucial role improving performance evaluation reconfiguration new existing facilities supporting management decisions providing tools guarantee real time performance monitoring therefore necessary research implement underlying models ideas foundation stage new conceptual framework designed implemented next generation factories supported suitable information communication technologies ict digital infrastructures lay foundations future applications research area industrial paradigm factory product line context presented propose development factory templates address design operation practices throughout entire life cycle factory different dimensions factory templates presented paper cover design creation factory remodelling even disassembly recycling stages entire study takes account relevant factors costs quality time flexibility environmental social issues energy efficiency throughout article different kinds models presented describe adjust structure analysis design development factory integration project helps provide formal analysis system furthermore templates integrating factory response internal external disturbances also developed elsevier ltd rights reserved
study examined impact selective anxiety prevention program offspring clinically anxious parents three domains child functioning social familial emotional behavioral dyads randomized either coping promoting strength program caps information monitoring comparison group multi informant assessments conducted baseline post intervention months follow ups random effects mixed models linear growth modeling lgm framework used assess impact caps growth trajectories time children caps group significantly lower anxiety anxious depressed symptoms lower total behavior problems parent report compared children group intervention impact domains assessed social functioning may due floor effects measures longitudinal follow data needed provide valuable information high risk population
stress management resilience learning learn self esteem empathy life skills play pivotal role psychosocial development youth prepared manage everyday challenges caring toward people animals hypothesized dog club membership associated improved life skills youth participating activities compared youth surveyed washington idaho youth years old three conditions clubs conducting dog focused activities dog clubs clubs conducting activities involving dogs non dog clubs school youth involved school group life skills attitude toward attachment pets assessed using emotional quotient inventory youth version short self perception profile children social skills improvement system rating scales pet attitude scale lexington attachment pets scale analysis covariance used evaluate main effects condition covariates age sex number siblings dog home two way interaction effects questionnaire scores condition affected scores youth dog clubs higher stress management scores compared non dog clubs school group conditions higher scholastic competence global self worth scores compared school group much variation scores remains unexplained predictors investigated thus extent results represent interest dog activities due pre existing characteristics opposed changes resulting experience unclear nevertheless study participants least one dog condition effects detected accounting dogs home suggesting activities involving dogs beneficial effects benefits resulting dog contact per
aims studies compared time trends incidence psychosis date results inconsistent showing decline increase significant change far know studies explored changes prevalence early risk factors aim study investigate differences early risk factors cumulative incidences psychosis type psychosis two comparable birth cohorts methods northern finland birth cohorts nfbcs prospective general population based cohorts children followed since mother mid pregnancy data psychoses schizophrenia narrow spectrum bipolar disorder psychotic features major depressive episode psychotic features brief psychosis psychoses icd collected nationwide registers including inpatients outpatients data early risk factors including sex place birth offspring parental age psychosis maternal education birth prospectively collected population registers follow reached age years results increase cumulative incidence psychoses seen nfbc nfbc due increase diagnosed affective psychoses earlier onset cases relatively psychoses women observed nfbc changes prevalence potential early risk factors identified parental psychosis significant predictor cohorts hazard ratios difference psychosis incidence dependent changes prevalence studied early risk factors conclusions surprisingly increase cumulative incidence psychosis also changes types psychoses found two birth cohorts years apart observed differences could due real changes incidence attributable changes diagnostic practices early psychosis detection treatment
research intelligent procedure designed implemented based vibration signals detecting classifying prevalent faults internal combustion engine timing belt vibration signals timing belt captured operation six different states healthy tooth crack back crack wear separated tooth oil pollution signals processed three domains namely time frequency time frequency domains time domain signals transformed frequency time frequency domains using fast fourier transform wavelet transform respectively six statistical features extracted vibration signals three domains extracted features used inputs artificial neural network primary classification timing belt defects classification accuracy artificial neural network detecting classifying timing belt faults time frequency time frequency domains obtained respectively combining separate classification accuracies time frequency time frequency domains implemented using dempster shafer theory evidence classification accuracy based fusion time frequency domain classifiers time time frequency results frequency time frequency results also whereas combination results domains led accuracy results show proposed methodology detect classify timing belt defects high precision reliability failure occurrence
studies found traumatic experiences childhood lasting effects across lifecourse adverse childhood experiences aces include variety types trauma including psychological physical sexual abuse living poverty violence home living substance abuser living mentally ill suicidal person living someone imprisoned long term effects among adults found previous studies limited research association aces adolescent development even less potential protective factors mediate associations utilizing national survey children health study examines prevalence aces nationally representative sample year old adolescents cross sectional relationship experiencing aces multiple measures well potential protective factors examined mediation model results indicate aces adolescents experience less likely enjoy high levels well many factors partially mediate association including residing safe neighborhood attending safe school parental monitoring friends activities conclude measures adverse childhood experiences aces represent important construct indicator systems addition findings indicate measures protective factors represent important components indication systems
algorithm symbolic computation aluthge transform polynomial matrix derived paper purpose well known psvd pqrd algorithm considered avoid square roots polynomials aluthge transform matrix algorithm symbolic computation polar decomposition polynomial matrices developed well furthermore aluthge transform rank one matrices defined cross products vectors symbolically calculated presented closed formula
due impact society design new drugs potential interest wide audience provides rare opportunity introduce several concepts chemistry biochemistry drug design seen multiobjective cyclic optimization process indeed important develop understanding drug generally effective ligand protein therapeutic interest also molecules need drug like properties computer aided drug design bioinformatics approaches play fundamental role addressing different challenges introduce new freely available integrated web based educational tool drug design workshop presents basics drug design provides anyone access computational methods resources conceive evaluate molecules potential become actual drugs provide examples drug design targets discovery common state art drugs used educators introduce easily different concepts related drug discovery anti inflammatory agents drugs immunotherapy targeted cancer therapy since workshop successfully given people web site optimized basis positive constructive comments high school teachers students years old
background increasing recognition risks associated hypoglycemia patients diabetes studies investigated incident cause specific cardiovascular outcomes regard low fasting glucose general population objective hypothesized low fasting glucose would associated cardiovascular disease risk cause mortality postmenopausal women methods test hypothesis used continuous incidence rates cox proportional hazards models participants women health initiative fasting glucose measured baseline participants separated groups based fasting glucose level low results participants free cardiovascular disease enrollment mean age years caucasian african american asian hispanic median follow years graphs continuous incidence rates compared fasting glucose distribution exhibited evidence weak shaped association heart failure mortality predominantly due participants treated diabetes impaired diabetic fasting glucose positively associated outcomes associations low fasting glucose differed coronary heart disease significantly inverse stroke combined cardiovascular disease cause mortality null inverse significant heart failure positive significant conclusions fasting glucose upper range lower range significantly associated incident cardiovascular disease cause mortality elsevier inc rights reserved
rheumatoid arthritis ankylosing spondylitis psoriatic arthritis associated potentially sight threatening inflammatory eye disease although ocular manifestations associated ankylosing spondylitis psoriatic arthritis similar anterior uveitis differs rheumatoid arthritis dry eye peripheral ulcerative keratitis scleritis major ocular complications apart causing sight loss conditions painful debilitating often recurrent chronic may require long term therapy treatments ocular lubricant topical corticosteroid systemic corticosteroid systemic immunosuppression often similar underlying systemic disease yet treatment ocular complications evidence base weak close collaboration rheumatologist often essential particularly management patients elsevier ltd rights reserved
background biologicals directed tumour necrosis factor tnf proven efficacy treatment spondyloarthritis rheumatoid arthritis present radiolabelling method certolizumab pegol czp commercially available humanized fab fragment directed tnf biodistribution dosimetry study conducted hynic czp synthesized vitro tnf neutralizing activity tested exposing cells various concentrations mtc hynic czp measuring tnf induced cytotoxicity biodistribution dosimetry images blood urine sampling performed cumulative activities estimated using mono exponential fitting organ doses estimated using olinda exm effective dose calculated using international commission radiological protection recommendations uptake tracer peripheral joints assessed visually semiquantitatively results vitro tests showed blocking tnf cytotoxicity hynic czp formulation comparable effect obtained unlabelled czp without hynic linker analysed eight patients rheumatoid arthritis spondyloarthritis highest mean absorbed organ doses recorded kidneys spleen liver mbq effective dose msv mean injected activity mbq urinary excretion blood analysis yielded distribution half life elimination half life visual analysis scans revealed marked tracer accumulation clinically affected peripheral joints addition statistically significant higher uptake tracer swollen joints median uptake ratio compared background rheumatoid arthritis peripheral spondyloarthritis compared clinically negative joints respectively conclusions present radiolabelling technique czp fab fragment directed tnf currently used therapeutic agent rheumatology effective dose msv estimated confirmed uptake new radiopharmaceutical clinically affected peripheral joints
volumetric efficiency air charge estimation one demanding tasks control today internal combustion engines specifically using three way catalytic converter involves strict control air fuel ratio around stoichiometric point hence requires accurate model air charge estimation however high degrees complexity nonlinearity gas flow internal combustion engine make air charge estimation challenging task obvious engines variable valve timing systems gas flow complex depends functional variables results models either quite empirical look tables interpretability extrapolation capability physically based models appropriate onboard applications solving problems novel semi empirical model proposed work needed engine speed load valves timings volumetric efficiency prediction accuracy generalizability model shown test numerical experimental data three distinct engines normalized test errors three engines respectively also performance complexity model compared neural networks typical black box models complexity model less half complexity neural networks computational cost approximately neural networks prediction capability considered case studies usually results show superiority proposed model conventional black box models neural networks terms accuracy generalizability computational cost
political communication scholars shown nonverbal communication cues potential influence political judgments bulk literature focused leader displays context electoral politics study reported aligns body literature tests facial displays ordinary citizens might affect political participatory intentions among different demographic groups study reported provides support idea exposed audiovisual news features emotional testimonies people firsthand experience social issues encourages political participation findings mixed design experiment examining story personalization ideological strength education level offer evidence participants higher lower socioeconomic segments society become equally motivated political participation viewing emotional testimony fellow citizens reasonable start considering potential news gives voice ordinary people showcasing facial displays emotion revitalizing public sphere
purpose autologous matrix induced chondrogenesis amic utilizing type iii collagen membrane compared microfracture mfx alone focal cartilage lesions knee one two five years methods forty seven patients aged years mean defect size randomized treated either mfx sutured glued amic prospective multicentre clinical trial results improvement first two years subgroups progressive significant score degradation observed mfx group functional parameters remained stable least five years amic groups two five years mri defect filling complete amic groups treatment related adverse events reported conclusions amic effective cartilage repair procedure knee resulting stable clinical results significantly better mfx group five years
psychiatric patient prisoner certified treated involuntarily saskatchewan mental health services act regional psychiatric center mentally ill incapable making treatment decision likely cause harm self others retrospective study examined treatment certified patients year period total patients treated using certifications separate hospital admissions fifty certified patients required one certification required another certification within three months first certification among certified schizophrenia related psychosis substance use disorder antisocial personality disorder common discharge diagnoses antipsychotics frequent discharge medications global assessment functioning score patients improved significantly admission discharge functional improvement may suggest beneficial use certification keeping patients treatment benefit may enhanced statutory duration certification increased account length time required adequate resolution symptoms reduce need repeat certification
due complex building experiment environment difficulty analysis correctness performance algorithm algorithm design experiment information science courses paper web based virtual lab platform algorithm learning designed developed platform resource packaged web service student able submit source code algorithm developed multi programming language server choose corresponding virtual experiment component build experiment process testing algorithm platform enable student concentrate design optimization algorithm last virtual experiment system digital image processing illustrates effectiveness platform
water resources assessment arid lands particular interest scientific terms also concept sustainable development study area ambagi basin represents remote arid area scarcity data measured effective porosity permeability revealed high potentialities nubian sandstone oligocene sediments hydrogeologic setting indicates favorable conditions groundwater accumulation opportunity recharge thus sustainability groundwater research approach based geological investigations well several data layers gis environment including landforms lithology slope soil morphometric parameters structural lineaments geophysical data several specific sites suggested targets future groundwater explorations studied basin contains four sub basins intensive drainage network morphometric parameters revealed potential surface runoff occurrence also groundwater recharge two investigated sub basins show high hazard degrees protected avoid flash floods estimated runoff volume single rainfall event reach hence management rainwater harvesting protection measures flash floods necessary future water resources management strategy based results multidisciplinary study proposed
benchmarks required determine environmental performance new buildings lca study assessed environmental impacts elementary school buildings south korea conducting statistical analysis pearson correlation analysis partial correlation analysis mann whitney test gross floor area latitude longitude influence factors cause differences environmental impacts among buildings differences environmental impacts gross floor area considered defining functional unit one square meter floor area differences environmental impacts region considered dividing elementary school buildings according latitude longitude based results two step cluster analysis mann whitney test latitude longitude environmental impacts elementary school buildings divided two clusters exception human carcinogenic potential human non carcinogenic potential therefore study presented benchmarks two clusters instance benchmarks global warming potential clusters one two respectively benchmark human carcinogenic potential cases benchmarks expected used deterinining environmental performance new elementary school buildings elsevier rights reserved
study aimed identify analyze prevalence physical psychological family violence sample children adolescents different categories disabilities hospital rio janeiro brazil cross sectional observational study based application parent child conflict tactics scale sample parents guardians prevalence psychological aggression physical maltreatment children adolescents disabilities suffered physical punishment also victims psychological aggression suffered severe physical maltreatment also suffered psychological aggression children adolescents disabilities showed increased risk suffering family violence compared without disabilities conclusion need greater awareness raising training health teams detection notification child abuse efforts made support families
work describes practical implementation floating interleaving boost converter fibc fuel cell applications paper aims validate concept digitally controlled four phases fibc fuel cell applications fibc exhibits interesting performance terms magnetics input output current ripple part count distributed power losses potential field application indeed medium higher power fuel cell front end converters minimizing input current ripple significant also redundancy reliability crucial actually approach covers aspects since provide module device redundancy real time flexible digital control reconfiguration relevant aspects related design modeling simulation experimental verification arduino controlled phases fibc treated paper
accelerated testing photovoltaic module important procedure know effect weather outdoor exposure module cell temperature depends environmental parameters ambient temperature global irradiation wind velocity type mounting configuration type technology paper effect irradiance temperature estimate acceleration factor glass eva tedlar mono crystalline silicon modules studied trail arrhenius behavior indoor outdoor operation composite climate national institute solar energy gurgaon india irradiance temperature glass cell polymer sheet glass cell glass calculated using equivalent effective eff temperature maximum teq teff temperature found degrees degrees mol activation energy glass cell polymer sheet similarly degrees degrees maximum values aff found glass cell glass mol activation energy present study mol glass cell polymer sheet configuration required time simulate outdoor exposure comparison values activation energy elsevier ltd rights reserved
contractor selection decision important greatly impacts overall success project therefore need quantitative methods help stakeholders including owners make better decisions contractor selection although previous studies presented different methodologies contractor selection subject contractor selection remains attractive many researchers paper enhances construction management profession introducing new contractor selection method incorporates multiple decision makers paper introduces quantitative fuzzy set method assist contractor selection process implementing multiattribute decision making integrates group decision makers although preferred attributes contribute contractor selection dependent project method presented paper implemented attributes determined important contractor selection specific case method introduced research reported paper intended help decision makers rank different contractors based various attributes triangular fuzzy set model implemented define linguistic terms used describe subjective judgment related decision makers experience level attribute weight assessment selection attributes rating many uncertainties ambiguities arise contractor selection decision multiattribute group decision time pressure therefore fuzzy weighted average method used simulate grouping multiple decision makers research reported paper models different levels experience decision makers involved evaluation process decision makers using fuzzy membership functions express experience level different decision makers input beliefs importance set attributes contribute decision prequalify given contractor using linguistic terms converted membership functions decision makers rate different contractors five contractors using linguistic terms converted membership functions represent degree decision makers believe contractor meets set criteria important prequalification decision results research reported paper provide project stakeholders valuable insights contractor selection problem computer program uses fuzzy logic approach modeling multiattribute decision making process introduced program implemented stakeholders make better contractor selection decisions computer program validated five developers real case study results computer program agreed actual contractor selected developers project new contribution paper lies fact implements subjective judgment using fuzzy logic contractor selection decision introduces multiple decision makers quantitative solution introduced research reported paper american society civil engineers
maps solar irradiance readily available represent economic viability solar project particular location paper provides financial analysis different electricity tariffs maps internal rate return irr solar load displacement projects examine locations southwestern usa show irr maps differ substantially irradiance maps analysis includes scenarios derived following combinations three types solar installations concentrated photovoltaic cpv south facing oriented optimize irr three project start dates three price projections grid connected systems optimistic central pessimistic variation irradiance across locatibns much lower variation irr direct normal irradiance almost uncorrelated irr cpv projects indicating irradiance alone poor predictor irr tariff differences among locations including time use aspects play major role determining economic viability irr varies considerably even within single city orienting modules optimize irr brings little benefit unless optimized azimuth greater west south elsevier ltd rights reserved
accessible summary known subject care adult son daughter psychosis filled overwhelming demands caused symptomatology illness exacerbations parents display disenfranchised grief multiple losses report increased levels emotional burden studies use quantitative methods rely pre existing theoretical frameworks investigate psychometric measures effects carer meaning attributions disorder changes parent child relations time poorly understood paper adds existing knowledge hermeneutic phenomenological study illuminates subjective experience parenting son daughter psychosis lived described parents young adults psychosis findings suggest parents perceptions child changes course disorder leading redefinition parent child relationship causing alternations attachment findings illuminate parents profound guilt contributed prevented disorder good parents feeling ambivalent towards intimate stranger guilt compensated absolute dedication son daughter care expense well implications practice interventions parents must available soon possible hospitalization discharge professionals provide therapeutic space parents could express intimate thoughts feelings address guilt fear resentment issues assisted parenting role well reconstruction sense self self esteem professionals invited facilitate illness acceptance provide accurate information assist parents redefine relationship child facilitate integration traumatic experience personal family narrative professionals must develop depth awareness biases attitudes ongoing training respond parents needs facilitate therapeutic change accompany families course adult child illness trajectory abstract introduction children diagnosed psychosis often rely parents prolonged care impact care partially understood studies use quantitative methods pre existing theoretical frameworks limit investigation emotional burden emotional responses aim explore parents lived experience caring child psychosis method hermeneutic phenomenological design used sample parents children psychotic disorders hospitalized attended outpatient clinic large psychiatric greek hospital results identified themes follows psychosis experience redefinition parent child relationship course disorder iii challenges parenting child psychosis discussion caring intimate stranger reflects parents overall experience involving changes parent child relationship ambivalence towards caretaking profound guilt compensated self sacrifice parenting practices implications practice findings highlight necessity train mental health professionals provide individualized information facilitate family communication address parents guilt ambivalence meaning attributions compromise adjustment support challenges parenting son daughter psychosis
smart cards well known tamper resistant devices due portability security represent excellent platform implementing strong authentication services contribution analyses three spanish smart card deployments intended used egoverment services comparing respective contents capabilities result analysis conclude current deployment smart cards electronic prescription service rolled throughout spain could replaced use already consolidated spanish national identity card
introduction idiopathic pulmonary fibrosis ipf diffuse parenchymal lung disease cure recently treatment proven alter natural history judged rate lung function decline however emergence two novel anti fibrotic agents pirfenidone nintedanib revolutionized management condition demonstrated ability deliver major reduction rate chronic ipf progression areas covered review article focuses pirfenidone pyridone derivative initially designed analgesic anti pyretic agent describe history drug inception exploratory pre clinical vitro vivo studies anti fibrotic potential identified eventually large multicenter randomized controlled trials expert commentary article also summarizes difficulties surrounding clinical end point selection ipf trials addresses challenges facing ipf community coming years
paper new neural network observer based optimal tracking control presented attenuate effect backlash uncertainty position tracking multi motor servomechanism mms adopting continuously differentiable function instead non differential dead zone model backlash state space representation mms set using linear part differentiable function based state space representation optimal neural network observer used estimate uncertainties unmeasured states combines optimal state feedback synthesis actual control law finally lyapunov theory utilized certify tracking error observed error neural network weights semi globally uniformly ultimately bounded sguub simulation results validate effectiveness method
therapeutic tasks forensic psychiatry range field tension improvement security entrusted persons respect aspects paradoxical position politics society seen whereas regulatory security aspects emphasized detention measures required respect treatment measures according penal code stgb relaxation rules critically viewed pressure european jurisprudence preventive detention declared therapeutic measure superordinate priority measures prevent recidivism article firstly summarizes empirical evidence concerning efficacy forensic psychiatric treatment relevant disorders becomes obvious data unreliable due relevant risk aspects therefore comparison safety therapeutic interests remains challenging undertaking working approach successfully encompass aspects long term case management position justice inpatient interaction dynamic aspects treatment process beyond detention effectiveness aftercare confirmed propose implementation forensic outpatient treatment alternative forensic inpatient treatment
objective identify psychiatric diagnoses psychosocial factors associated intentional male genital self mutilation gsm specific injury subtypes methods search medline embase psycinfo pubmed web science cinahl cases gsm conducted december based gsm related terms cases examined injury subtype psychiatric diagnosis psychosocial factors chi square analyses employed determine differences frequency factors across injury subtypes results data obtained cases genital mutilation penile amputation castration combined amputation castration common psychiatric disorders included schizophrenia spectrum substance use personality gender dysphoric disorders chi square analyses revealed schizophrenia spectrum disorders occurred significantly often among auto amputates compared self castrators mutilators gender dysphoria occurred significantly often among self castrators auto amputates significant differences emerged regarding psychosocial factors across gsm subtypes however associations observed psychosocial factors psychiatric diagnoses although altogether commonly reported experiential factors reported psychotic individuals treatment inaccessibility noted among gender dysphorics engaging auto castration conclusion clinicians must consider diverse range psychiatric disorders psychosocial factors underlying gsm elsevier inc rights reserved
paper presents brief analysis renewable energy infeed based historic data wind speed weather station power output existing photovoltaic power plant standard load demand publicly available distribution system operators three data prepared used run single node model implemented matlab simulink single node model consist load block renewable energy source wind solar reference source simulation shows power profile excess renewable energy production absorbed storage system paper also presents brief performance analysis power wind energy source goes establish need depth analysis driven data smaller sample space spanning longer time frame obtain accurate results result inform process proposing set rules tool sizing placement storage electrical network
atopic dermatitis chronic inflammatory skin disease manifests intractable itch underlying mechanisms poorly understood study assessed relationship immunoglobulin igg dorsal root ganglia drg nga mice model manifests like symptoms including itch immunohistochemical analysis showed large amounts igg drg extracts nga mice like dermatitis large fraction igg distributed satellite glial cells drg proteomic analysis showed igg reactive tropomyosin dermatophagoides farinae findings indicate accumulation anti tropomyosin igg drg atopic nga mice may associated pathogenesis like symptoms including itch elsevier inc rights reserved
essay examines role racial ethnic cultural bias custody cases analyzes cases court explicitly considered parents racial ethnic cultural background cases court acknowledge factors clear court opinion biases influenced decision briefly describes literature implicit bias demonstrate biases may influence assessments custody evaluators lawyers judges despite best efforts make fair impartial decisions drawing studies suggesting individuals reduce implicit biases effects decision making essay explores individual strategies institutional reforms address bias custody disputes key points family court community custody evaluators lawyers judges influenced racial ethnic cultural backgrounds parents child custody disputes implicit biases may influence custody evaluators lawyers judges interpret parents behaviors testimony preferences parenting styles favored middle class families disproportionately disadvantage racial ethnic minorities low income families best interests child standard increases risk intuitive biased assessments acknowledgement racial ethnic cultural differences necessary reduce bias individual strategies institutional reforms may help reduce bias effect assessments decision making custody cases
introduce game trusted computation sensor equipped limited computing power leverages central computer evaluate specified function large dataset collected time assume central computer attack propose strategy sensor retains limited amount data counteract effect attack formulate problem two player game sensor defender chooses optimal fusion strategy using non trusted output central computer locally stored trusted data attacker seeks compromise computation influencing fused value malicious manipulation data stored central computer first characterize nash equilibria game turn dependent parameters known players next adopt iterated best response ibr scheme iteration central computer reveals output sensor computes best response based linear combination private local estimate untrusted third party output characterize necessary sufficient conditions convergence ibr along numerical results show convergence conditions relatively tight elsevier ltd rights reserved
motivated applications relational databases alechina proposed many sorted first order logic specialized models called models ordinary first order structure equipped system functions realizing functional dependences variables interpreted attributes due constraints restricted set assignments available model factor may rouse undesirable effects formulas language evaluated develop relevant first order languages another assignment free algebraic semantics based improved models
paper examines motivation applications development short term solar forecasting using ground based sky imagery controlling equipment electrical grids historically great deal interaction fields solar forecasting electrical grid research situation changing rapidly solar forecasting becoming increasingly important dealing mass uptake photovoltaics solar thermal generation electrical grids around world interactions two fields examined along opportunities applying solar forecasting grid mini grid applications review solar forecasting techniques summarise applications evaluate links suitable techniques applications review current solar forecasting techniques including numerical weather prediction nwp statistical data driven approaches satellite techniques presented also compare characteristics technique illustrate requirements status suitability use short term solar forecasting applications application sky camera skycam forecasting electrical grids discussed addition presentation detailed case study demonstrating use techniques enhance grid operation control strategy developed demonstrates increase real time penetration renewable power dynamically adapting solar inverter setpoints according cloud forecast data novel short term solar forecasting system presented makes use inexpensive ground based sky imaging cameras skycams system able predict changes irradiance forecasting cloud movement min ahead update frequency several novel techniques skycam setup forecasting presented include new high performance approach cloud classification using novel set neural network input features new method calibrating lens distortion model novel technique using per pixel cloud movement vectors predict timing extent sun shading events latter technique capable correctly classifying cloud pixels validation database examples finally present new technique taking features extracted sky camera pixel data building model predicting large shading events show example model easily adapted either conservative aggressive operation solar power system backup generator conservative operation model shown supply adequate excess energy time using min ahead forecasts used scheduling backup electrical generator meaning system would require minimal battery storage producing large reduction fossil fuel consumption crown copyright published elsevier ltd rights reserved
current mode first order allpass filter app using active elements studied present paper proposed circuit comprises two operational transconductance amplifiers otas one operational amplifier suitable future development integrated circuit pole frequency phase response electronically adjusted changing bias currents otas apf high output impedance easy cascade high order filter drive load without using buffering device current mode quadrature oscillator included show usability proposed filter results pspice simulation accordant theoretical analysis
paper system proposed combine small finger movements large scale body movements captured motion capture system strength proposed work previous research real time performance integrating small scale finger hand animation full body skeletal animation provides higher degree immersion interactivity compared traditional virtual reality systems use traditional user interfaces number experiments conducted humanoid skeletons similar actual human swat officer dissimilar gremlin showcase performance proposed approach
present study conducted meta analysis systematic review current evidence assess efficacy probiotics preventing treating small intestinal bacterial overgrowth sibo relevant studies pubmed embase cochrane central register controlled trials may assimilated prevention efficacy assessed incidence sibo probiotic group treatment efficacy sibo decontamination rate reduction concentration symptom improvement relative risk weighted mean difference wmd used effect measures random effects model used meta analysis total full text articles abstracts included systematic review studies eligible data synthesis patients probiotic usage showed insignificant trend toward low sibo incidence confidence intervals pooled sibo decontamination rate probiotics group showed significantly higher sibo decontamination rate nonprobiotic group also concentration significantly reduced among probiotic users wmd ppm ppm although probiotics produced marked decrease abdominal pain scores wmd significantly reduce daily stool frequency wmd therefore present findings indicated probiotics supplementation could effectively decontaminate sibo decrease concentration relieve abdominal pain ineffective preventing sibo
robust evidence linking interindividual differences positive affect adaptive psychological physical health outcomes however recent research suggested intraindividual variability fluctuations states time may also important predictor individual health outcomes report research focuses level various forms dynamics variability instability inertia reactivity relation health level refers average level positive feelings contrast dynamics refer short term changes unfold time discuss consideration level dynamics provide framework reconciling high conducive detrimental health conclude work dynamics needed especially combination level suggest productive questions future inquiry area karger basel
requirements engineering includes processes intended elicit analyse specify validate systems software requirements throughout software life cycle mastering principles key achieving goals better cheaper quicker systems software development projects also important prepared work remote teammates distributed global projects becoming common paper presents experiment total students two universities spain morocco assigned either located distributed team traditional reuse based requirements specification techniques applied participants produce requirements documents outcomes analysed approaches compared point view effect set performance based perception based variables located distributed settings found significant differences productivity difficulty regards scores attained non reuse reuse conditions located modality findings show general participants attained similar results requirements specification using two strategies distributed non distributed environments copyright john wiley sons ltd
backgroundexcessive ethanol etoh consumption remains important health concern effective treatments lacking central oxytocin system emerged potentially important therapeutic target alcohol drug addiction studies tested hypothesis oxytocin reduces etoh consumption methodsmale cbl mice given access etoh using model binge like drinking drinking dark also included use lickometer circuits evaluate temporal pattern intake well bottle choice drinking home cage addition etoh sucrose self administration fixed progressive ratio schedules also evaluated wide range systemically administered oxytocin doses tested models resultsoxytocin dose dependently reduced etoh consumption maximal reduction binge drinking model lower effective doses minimal effects general locomotor activity oxytocin effect blocked pretreatment oxytocin receptor antagonist pattern contacts licks etoh bottle suggested reduction motivation drink etoh oxytocin decreased bottle choice drinking without altering general fluid intake oxytocin also reduced operant responding etoh sucrose dose related manner however oxytocin decreased responding motivation breakpoint values etoh doses alter responding sucrose conclusionsthese results indicate oxytocin reduces etoh consumption different models self administration effects likely due general sedative effect neuropeptide oxytocin reduces motivation etoh doses alter responding natural reward sucrose evidence supports role oxytocin receptors mediating effects additional studies needed elucidate underlying mechanisms nevertheless results support therapeutic potential oxytocin treatment alcohol use disorder
independently adjustable multielectrode arrays routinely used interrogate neuronal circuit function enabling chronic vivo monitoring neuronal ensembles freely behaving animals single cell single spike resolution despite importance approach widespread use limited highly specialized design fabrication methods address developed scalable lightweight integrated quick assemble multielectrode array platform platform additionally integrates optical fibers independently adjustable electrodes allow simultaneous single unit recordings circuit specific optogenetic targeting manipulation current designs fully assembled platforms scalable microdrives yet range light enough small animals describe design process starting intent computer aided design parameter testing finite element analysis experimental means implementation various applications across mice rats combined methods may expand utility multielectrode recordings continued integration tools enabling functional dissection intact neural circuits
propose bayesian approach person perception outlining theoretical position methodological framework testing predictions experimentally use term person perception refer perception others personal attributes age sex also perception social signals direction gaze emotional expression bayesian approach provides formal description way perception combines current sensory evidence prior expectations structure environment expectations lead unconscious biases perception particularly evident sensory evidence uncertain illustrate ideas reference recent studies gaze perception show people bias perceive gaze others directed towards also describe potential application study perception person sex bias towards perceiving males typically observed elsevier inc rights reserved
skeletal surveys currently considered standard care evaluation fractures infants suspected abuse well described subtle fractures may missed soft tissue visceral injuries often undetected using radiographic modality whole body mri mri mainly used oncology infectious disease however application field child abuse pediatrics well studied present case illustrates potential utility mri using magnet evaluating infants suspected child abuse elsevier ltd rights reserved
although studies based satellite gravimetry laser altimetry measurements achieved region wide glacier mass change tien dynamic process glacier yet closely monitored understood impact assessed accurately study investigated region wide glacier thickness change central tien cts differencing shuttle radar topographic mission srtm digital elevation model dem newly constructed dem tandem images total glacier area average glacier thickness change rate derived result agrees well result based satellite laser altimetry measurements reported earlier temporal synchronization fine spatial resolution wide coverage measurements able reveal abundant glacier change features dependencies cts firstly lower mountains seen severe glacier decline glaciers facing prevailing wind westerlies experienced greater decline stronger evaporation furthermore glaciers lying along extremely high meridian mountain range obviously gained mass upper reaches air current west blocked lifted meridian mountain range secondly entire glacier body theoretical hyperbolic dependence debris thickness ice decline difficult establish huge glaciers covered heavy debris still experienced severe decline however even though heavy debris prevent ablation attenuating effects considerable thirdly glaciers surged mass gain restoring zones enough cover mass loss ablation zones large glaciers surged however much lower magnitudes previous surges general surge glaciers experienced greater decline non surge glaciers fourthly due ice front calving subglacial thermal erosion glaciers connected proglacial lakes receded thinned much rapidly land terminated glaciers overall glaciers cts stable parts tien however glacier state still alarming moderate average thinning rate derived drastic thinning ablation zones balanced slight thinning broad accumulation zones elsevier inc rights reserved
although sleep disorders neurologic illness common burdensome right combined tremendous negative impact individual level well societally socioeconomic burden sleep disorders neurologic illness identified real cost conditions lies far beyond financial realm urgent need comprehensive care support systems help burden disease research improving patient outcomes suffer conditions help patients families society general
widely accepted human immunodeficiency virus type hiv envelope glycoprotein plays important role hiv induced neural injury pathogenesis hiv associated dementia hand multiple pathways proposed induced neurotoxicity amongst activation methyl aspartate receptors nmdars shown causes neuronal injury death transgenic mice exhibit neurological similarity hand blocked attenuated nmdar antagonists several lines evidence indicate subtype location activated nmdars key determinants nature nmdar physiology examine subtype location nmdars affected studied subtype nmdar mediated epscs region rat hippocampal slices blind whole cell patch recordings results showed bath application increased nra nrb mediated epscs possibly via presynaptic mechanism much stronger effect nrb mediated epscs contrast failed enhancing ampa receptor mediated epscs imaging studies revealed potentiated glutamate induced increase intracellular concentration rat hippocampal neuronal cultures blocked nmdar antagonist ampa receptor antagonist indicating induces influx nmdars investigations demonstrated increased epscs mediated extrasynaptic nrbrs taken together results demonstrate interacts nra nrb subtypes nmdars predominant action extrasynaptic nrb implicating role nrb may play hiv associated neuropathology
aimsaxonal degeneration pathological symbol early stage alzheimer disease triggered amyloid peptide deposition growing evidence indicates deficit autophagy eventually leads axonal degeneration previous studies shown dendrobium nobile lindl alkaloid dnla protective effect neuron impairment vivo vitro however underlying mechanisms still unclear methodswe exposed cultured hippocampus neurons investigate effect dnla vitro axonal degeneration evaluated immunofluorescence staining mtt assay neurons overexpressing gfp lcb used measure formation autophagosome autophagosome lysosome fusion lysosomal cathepsin activity assessed reflect autophagy process proteins interest analyzed western blot resultsdnla pretreatment significantly inhibited axonal degeneration induced peptide vitro studies revealed dnla treatment increased autophagic flux promoting formation degradation autophagosome hippocampus neurons moreover enhancement autophagic flux responsible protective effects dnla axonal degeneration conclusionsdnla prevents induced axonal degeneration via activation autophagy process could novel therapeutic target
study relies double sided chips capacitive micromachined ultrasonic transducers cmut manufactured sides silicon substrate order perform galvanic isolation two electrical circuits operating principle based propagation acoustic waves one transducer providing high level electrical isolation work presented focuses mainly assessment power efficiency experimental theoretical point view encouraging power efficiency values reached showing significant efficiency gain taking advantage coupling substrate
spinal cord stimulation therapeutic option chronic pain years neurostimulator device consisting three primary components electrode array configured either paddle wire implantable pulse generator ipg consisting minicomputer transceiver antenna electrical generator battery insulated wiring connecting electrode ipg electrode array implanted epidural space overlying dorsal spinal cord along peripheral nerve device generates pulsed electrical signals stimulate underlying dorsal columns spinal cord resulting perception paresthesia patient overlapped painful areas paresthesia help decrease patient level pain increased applications indications technology enhance likelihood patient seen dental practice therefore purpose study investigate whether electromagnetic interference occurred operation apex locator electric pulp tester ept electrocautery unit implanted epidural space human cadaver dental devices used intraorally implant circuitry tested trial two apex locators two epts one electrocautery unit tested seventy trials used dental device tissue using exact binomial method determining confidence intervals probability damage devices negligible endod
modern societies strong belief scientific progress unfortunately parallel partial regress occurs often avoidable mistakes mistakes mainly forgetting erroneous theories errors experiments manuscripts prejudice selected publication positive results fraud example forgetting methods introduced decades ago used without knowing underlying theories basic articles longer read cited omission may cause incorrect interpretation results instance false use actual base excess instead standard base excess calculation number hydrogen ions leaving muscles raised idea unknown fixed acid produced addition lactic acid exercise erroneous theory led conclusion lactate anion strong acid buffer mistakes occur incorrect application method exclusion unwelcome values evaluation measurements false calculations preparation manuscripts authors well reviewers always carefully read papers publication peer reviewers might biased hypothesis author general problem selected publication positive results example fraud sports medicine presence doped subjects groups investigated athletes reduce regress important investigators search original recent articles topic conscientiously examine data authors reviewers read text thoroughly inspect tables figures manuscript
soil moisture ocean salinity smos mission provided unique remote sensing capability observing key variables hydrological cycle sea surface salinity sss however due limitations related instrument interferometric concept challenging data processing smos sss maps still display significant artifacts biases especially close coast mainly due presence radio frequency interferences rfi land sea contamination lsc paper new methodology filtering salinity retrievals correcting spatial biases introduced validated elsevier inc rights reserved
bit low power successive approximation adc designed fabricated poly poly capacitor ams technology sar adc targeted bridge type pressure sensor wireless sensor node applications improved cascaded inverter based comparator used lower power consumption reduced supply voltage modified sar digital circuit incorporated accommodate higher input range adc given noise floor higher input range adc ensures enhanced snr performance relaxing constraint sensor interface circuit preceding adc also novel switching scheme used feedback comparator reduce charge injection induced offset without sacrificing useful bandwidth adc inverter based comparator consumes power operating speed mhz comparator make use offset cancellation techniques suitably choosing capacitor array inherent dac calibration techniques avoided adc adc achieves effective number bits consuming conversion speed khz fom whole adc found conversion step active area occupied adc
recently service function chaining sfc promising innovate network service mode modern networks however feasible implementation sfc still difficult due need achieve functional equivalence traditional modes without sacrificing performance increasing network complexity paper present configurable network service chaining cnsc mechanism provide services network traffics flexible optimal way firstly formulate problem network service chaining design effective service chain construction framework based integrating software defined networking sdn network functions virtualization nfv model service path computation problem integer liner optimization problem propose algorithm named spcm cooperatively combine service function instances network utility maximum policy procedure spcm achieve service node mapping defining service capacity matrix substrate nodes work optimal link mapping policies segment routing finally simulation results indicate average request acceptance ratio resources utilization ratio reach spcm algorithm respectively upon prototype system demonstrated cnsc outperforms approaches provide flexible scalable network services
nowadays many bridges extra width needed vehicle throughput order obtain precise finite element model complex bridge structures practical hybrid updating method integration gaussian mutation particle swarm optimization gmpso kriging meta model latin hypercube sampling lhs proposed demonstrating efficiency accuracy hybrid method model updating damaged simply supported beam proposed method applied model updating self anchored suspension bridge extra width showed great necessity considering results ambient vibration test results bridge model updating showed mode frequencies shapes relatively high agreement updated model experimental structure successful model updating bridge fills blanks model updating complex self anchored suspension bridge moreover updating process enables model updating issues complex bridge structures
bioactive compounds natural sources due widely recognized benefits exploited cosmeceutical ingredients among phenolic acids emerge interesting potential context review analyzes hydroxycinnamic acids derivatives multifunctional ingredients topical application well limitations associated use cosmetic formulations hydroxycinnamic acids derivatives display antioxidant anti collagenase anti inflammatory antimicrobial anti tyrosinase activities well ultraviolet protective effects suggesting exploited anti aging anti inflammatory agents preservatives hyperpigmentation correcting ingredients due poor stability easy degradation oxidation microencapsulation techniques employed topical application preventing degradation enabling sustained release based findings hydroxycinnamic acids present high cosmetic potential studies addressing validation benefits cosmetic formulations still scarce furthermore studies dealing skin permeation scarcely available need conducted order predict topical bioavailability compounds application
group streptococci gas cause wide spectrum diseases ranging benign pharyngitis skin infections severe invasive disease immune sequelae rheumatic fever rheumatic heart disease pharyngitis one frequent diseases caused gas highly prevalent school age children temperate climates major cause antibiotic use efficacious vaccine would reduce disease burden associated pharyngitis need care sick children importantly gas pharyngitis recognised main precursor acute rheumatic fever vaccine efficacious gas pharyngitis also prevent acute rheumatic fever rheumatic heart disease may also prevent post streptococcal glomerulonephritis invasive disease since gas pharyngitis one precursors clinical syndromes clearly articulated pathway clinical trial design leading gas vaccine registration review outlines clinical development strategy detailing phases development required registration candidate gas vaccine gas pharyngitis initially followed impetigo associated sequelae major advantages strategy first focused gas pharyngitis early proof principle followed studies clinical syndromes end goal availability preventive tool prevalent gas associated diseases globally elsevier ltd rights reserved
paper propose output observer design methodology linear single output systems shown among potential applications proposed observer used filtering fault detection purposes unlike traditional observers based state space representation system proposed observer design based input output representation system main advantage proposed observer simplicity design lower order original system
evidence suggests dissociation negative affect may precipitate binge eating extent dissociation may impact experience around binge eating unclear women bulimia nervosa completed week ecological momentary assessment protocol dissociation binge eating multilevel modeling used examine dissociation moderator binge eating greater time binge eating participants higher average dissociation subjects momentary dissociation greater one average within subjects trajectory characterized sharper increase binge eating participants higher average dissociation trajectories characterized sharper increases decreases binge eating momentary dissociation greater one average results support salience dissociation relation occurrence binge eating
migration acculturation psychiatric disorders may cause stress adaptation processes differently men women empirical research scarce retrospective study turkish migrants native german inpatients depressive anxiety disorders matched age gender diagnoses compared using item instrument assessment migration acculturation related stressors migstr gender differences prevalence stressors total sum stressors calculated compared migrants indigenous patients results showed higher global stress level migrants women men migration background regarding single stressors perceived loss status significantly prevalent pronounced men women whereas guilt feelings severe women turkish migration background compared men gender differences perceived stress taken account migration acculturation research
background invasive fungal infection ifi increased recent years due greater number risk factors ifi caused candida frequent although candida albicans isolated species currently decrease albicans increase species genus aims analyse epidemiology risk factors antifungal susceptibility blood culture isolates non albicans candida species hospital last years methods retrospective study conducted patients candidaemia admitted hospital candida isolates susceptibility fluconazole itraconazole voriconazole amphotericin fluorocytosine caspofungin micafungin anidulafungin determined means micro dilution technique sensititre yeast one izasa spain results total strains belonged non albicans candida species candida parapsilosis complex candida glabrata complex candida tropicalis candidci krusei candida lipolytica candida membranaefaciens candida pulcherrima common risk factor adults children catheter use observed non albicans strains resistant fiuconazole conclusions results work confirm necessary know epidemiology non albicans candida species vitro susceptibility species involved main risk factors especially patients predisposing conditions asociacion espanola micologia published elsevier espana rights reserved
present unit performs continuous time hybrid approximate computation analog digital signals functions continuous time cmos prototype system capable solving nonlinear differential equations order scalable higher orders nonlinear functions generated programmable clockless continuoustime bit hybrid architecture adc sram dac digitally assisted calibration used analog mixed signal blocks compared prior art chip makes possible arbitrary non linearities achieves lower power dissipation thanks technology scaling extensive use class analog blocks typically unit achieves computational accuracy rms solution times fraction several hundred total computational energy fraction hundreds depending equation details significant advantages observed computational speed energy two orders magnitude one order magnitude respectively compared obtained modern microcontroller rms error
many autophagy related genes knowledge identified crohn disease polymorphic sites genomic wide studies novel member microtubule associated protein map family maps microtubule binding proteins involved autophagy however expression potential functions understood first time discovered regulated maps autophagy level indicated inflamed epithelium among patients similarly tnbs induced murine colitis model maps expression obviously increased meanwhile found location maps active caspase acted apoptotic executor might indicate basis efficient cellular level maps silencing inhibited starvation induced expression active caspase partially via wnt catenin signaling activation hct cells finally demonstrated iwp inhibitor wnt beta catenin signaling reversed regulation active caspase induced maps sirna hct cells taken together results suggested maps regulated among patients maps related autophagy inhibits apoptosis intestinal epithelial cells iecs wnt catenin signaling pathway might play vital role protection intestinal mucosal barrier inhibition progression elsevier inc rights reserved
counter electrodes plays vital role electron transport operation qdsscs lower charge transfer resistance counter electrode electrolyte interface fecilitates improvement photoconversion efficiency present study describes novel facile spray pyrolysis method fabrication low cost alpha moo carbon composite alpha moo material used counter electrode qdsscs qdssc tio photoanode sensitized cadmium sulphide cds qds polysulfide electrolyte alpha moo composite counter electrode exhibited solar energy electricity conversion efficiency better cells used platinum cus counter electrodes qdsscs alpha moo composite used counter electrode gives stable reproducible performance improvement efficiency alpha moo ccomposite counter electrode mainly driven improvement photocurrent density decrease charge transfer resistance counter electrode electrolyte interface electrochemical impedence spectroscopy studies carried understand electron transport device various interfaces alpha moo composite shown electrocatalytic response reduction redox species polysulfide platinum cus
solubility alpha temperature pressure conditions typical hot isostatic pressing hip pore laden laser additive manufactured parts investigated equilibrium pressure radius containing pore hip function initial pore radius evaluated thermodynamics perspective found reduction pore radius one two orders magnitude well extremely high pore pressures order gpa result hip using density functional theory dft formation energies solutes pure matrix calculated several different types solutes including interstitial single crystal substitutional single crystal bar bar twin boundaries considered calculations solubility calculated based formation energies function temperature pressure although dissolution highly endothermic substitutional atoms especially crystallographic defects like twin boundaries found possess significantly lower formation energies interstitials corresponding solubility within matrix found low however increases substantially elevated pressure temperature conditions pores hip facilitates removal elsevier rights reserved
although child protective services cps child welfare agencies aim prevent maltreatment cases child abuse neglect recidivism common better understanding recidivism predictors could aid preventing additional instances maltreatment previous study identified two cps interventions predicted recidivism psychotherapy parent related reduced risk recidivism temporary removal child parent custody related increased recidivism risk however counter expectations previous study identify specific risk factors related maltreatment recidivism current study hypothesized cumulative risk total number risk factors would significantly predict maltreatment recidivism beyond intervention variables sample cps case files therapy parent would related reduced likelihood recidivism believed relation temporary removal child parent custody maltreatment recidivism explained cumulative risk study also hypothesized relation temporary removal child parent custody recidivism would mediated cumulative risk performing hierarchical logistic regression analysis first two hypotheses supported additional predictor psychotherapy child also related reduced chances recidivism however hypothesis supported risk significantly mediate relation temporary removal recidivism elsevier ltd rights reserved
paper presented synchronous reference frame control strategy applied single phase microgrid system connected renewable energy power source control strategy aims regulate active power flow optimize power factor point common coupling pcc whole control system carried synchronous reference frame pcc voltage frame direct current responsible active power regulation quadrature one regulates power factor direct current used regulate link voltage single phase converter consequently keeping active power balance system experimental results presented demonstrate system feasibility effectiveness
prior research suggests religiosity especially public religious participation related greater volunteerism however less known religious transmission across life course particular whether religiosity childhood linked later life volunteerism study investigates sample emerging adults south texas high percent hispanic americans percent specifically examine pathways childhood emerging adulthood religiosity leading secular volunteerism findings indicate childhood emerging adulthood religiosity associated greater volunteerism effects childhood religiosity emerging adulthood volunteerism mediated emerging adulthood religiosity findings provide confirmation importance childhood religiosity insofar religiousness persists adulthood words find emerging adulthood religiosity transmits childhood religiosity greater secular volunteerism later life furthermore emerging adulthood public religiosity robust direct effects volunteerism
objectives acute subacute exacerbations recognized severe complication rheumatoid arthritis associated interstitial lung disease ild nevertheless role intensive immunosuppression ild remains elusive attempted evaluate clinical characteristics efficacy immunosuppressive treatment exacerbated ild methods clinical data including respiratory function imaging treatment prognosis retrospectively collected patients ild required hospitalization university tokyo hospital due acute exacerbation patients subacute exacerbation patients results patients ild demonstrated significantly higher titers anticyclic citrullinated peptide antibodies compared patients japanese ninja registry suggesting role adaptive immunity immunosuppressive treatment suppressed deterioration pulmonary functions improved ground grass opacity consolidation particular patients less fibrosis computed tomography images showed better response treatment although five patients treated combination therapy including cyclophosphamide showed severely decreased lung volume intensive therapies provided good prognosis without fatalities average observation period days conclusions immunosuppressive therapy effective exacerbations ild severe cases low respiratory function intensive therapy including cyclophosphamide potential improve prognosis
work proposes digitally enhanced low drop voltage regulator ldo ultra high radio frequency identification uhf rfid passive tags ldo design approach based finite state machine fsm nature tag digital control injecting part fsm unconsumed current ldo loop enhance transient response flat output voltage obtained chip measurements shows ldo consumes quiescent current delivering output current voltage power efficiency observed circuit design fabrication performed using cmos technology
drug malabsorption one potential troubles bariatric surgery evidence diminished levothyroxine absorption reported patients bariatric surgery study reports cases hypothyroid patients well replaced thyroxine tablets year euthyroid thyrotropin tsh levels surgery roux gastric bypasses rygb biliary pancreatic diversions bpd months surgery patients elevated tsh levels patients switched oral tablets liquid formulation dosage min breakfast two three months switch tsh significantly reduced patients treated rygb treated bpd levels significantly changed rygb group tsh bpd group tsh results first show liquid could prevent problem malabsorption patients bpd confirm previous studies patients submitted rygb suggesting oral liquid formulation could circumvent malabsorption bariatric surgery
battery recovery effect phenomenon available capacity battery could increase battery sleep certain period time since last discharging accordingly battery work longer time takes rests consecutive discharging processes works time however effect considered design energy efficient topology control algorithms wireless sensor networks paper propose distributed battery recovery effect aware connected dominating set constructing algorithm bre cds wireless sensor networks bre cds network node periodically decides join connected dominating set nodes slept preceding round priority join connected dominating set current round nodes worked preceding round encouraged take sleep current round battery recovery detailed algorithm design presented computational complexity bre cds deduced node degree simulation results show bre cds significantly prolong network lifetime compared existing work copyright john wiley sons ltd
recent advances sediment source tracing fingerprinting procedures focussed primarily use novel sediment properties either easier measure provide improved source discrimination improved procedures representing estimating uncertainty associated final source apportionment results spatial variability source properties long recognised potential problem approach attempts explore nature magnitude variability wider implications source fingerprinting investigations contribution addresses issue particular reference surficial sediment sources reports results investigation aimed documenting magnitude nature spatial variability geochemical properties surface soils within single cultivated field exploring implications findings sediment source fingerprinting procedures samples surface soil collected points located within field particular attention directed extent spatial variability geochemical properties surface soil could potentially used fingerprints importance influence soil redistribution rate properties surface soil provision guidelines selecting sampling points degree correlation different soil properties implications numerical procedures employed sediment source fingerprinting studies novel aspect study caesium measurements used provide information magnitude spatial pattern soil redistribution rate within field influence soil redistribution rate causing systematic spatial variability fingerprint properties could explored elsevier ltd rights reserved
social network sites snss relatively new phenomena relationship snss psychopathology remains unclear purpose study evaluate type snss depressed adolescents use incidence depressive disclosure snss among study designed cross sectional sample consisted adolescents diagnosed depressive disorder confirmed sads non depressed adolescents children depression inventory social anxiety scale social network use questionnaire administered primary finding amount time spent internet snss significantly higher among depressed adolescents non depressed adolescents additionally depressed adolescents reported significantly higher disclosure anhedonia worthlessness guilt loss concentration irritability thoughts suicide snss intensity depression sharing significantly higher depressed group depressed young people use social networks express symptoms adolescents disclosure social networks may able guide relatives friends mental health professionals
geosynthetic structures created channel erosion protection offer environmental friendly benefits demonstrably lower construction lifetime costs similar hard structures geotextile mattress sloping curtain gmsc offers alternative countermeasure channel erosion present study experiments conducted investigate working mechanism effectiveness gmscs installed movable beds rectangular flume bathymetry plastic sand beds measured tests results showed presence gmsc led sediment deposition dune formation upstream downstream edges gmsc structure prevent bottom erosion near structure increase stability flow induced sediment scour erodible beds protected
lagrangian numerical approach simulation rapid landslide runouts presented discussed simulation approach based called particle finite element method moving soil mass assumed obey rigid viscoplastic non dilatant drucker prager constitutive law cast form regularized pressure sensitive bingham model unlike classical formulations computational fluid mechanics slip boundary conditions assumed basal slip boundary conditions introduced account specific nature landslide basal surface interface basal slip conditions formulated form modified navier boundary conditions pressure sensitive threshold special mixed eulerian lagrangian formulation used elements basal interface accommodate new slip conditions particle finite element method framework avoid inconsistencies presence complex shapes basal surface flux condition basal surface relaxed using penalty approach proposed model validated simulating laboratory tests real large scale problem critical role basal slip elucidated copyright john wiley sons ltd
hospitals multiple data sources embedded systems monitors sensors number data available increasing information used care patient also assist decision processes introduction intelligent environments health care institutions adopted due ability provide useful information health professionals either helping identify prognosis also understand patient condition behind concept arises intelligent system track patient condition critic events health care system great advantage adaptable environment user needs system focused identifying critic events data streaming vital signs ventilation particularly valuable understanding patient condition work aims demonstrate process creating intelligent system capable operating real environment using streaming data provided ventilators vital signs monitors development important physician becomes possible crossing multiple variables real time analyzing value critic variation clinical importance
problem project management performed optimization task uncertainty subject real world constraints use probability theory insufficiently proved methods due unavailable data indeed need different methods best way evaluate uncertainty one approaches based application fuzzy sets theory since inception theory fuzzy sets advanced variety ways many disciplines applications theory found example artificial intelligence computer science medicine control engineering decision theory expert systems logic management science operations research pattern recognition robotics paper proposes fuzzy decision making approach project selection problem uncertainty evaluation provided illustration proposed approach conclusion show method help decision makers selection appropriate project based profitability
introduction anti tnf drugs represented epochal revolution treatment rheumatoid arthritis spondyloarthritis field axial spondyloarthritis golimumab fully human monoclonal anti tnfa administered subcutaneously every weeks shown significant efficacy good safety patients ankylosing spondylitis recently also indicated effective treatment patients suffering non radiographic axial spondyloarthitits areas covered systematic literature search completed using largest electronic databases medline embase cochrane aim review data concerning administration golimumab patients suffering axial spondyloartritis expert opinion week ahead study golimumab effective patients non radiographic spondyloarthritis high levels crp positive mri findings subjects negative crp mri finding allows addressing anti tnf treatment specifically preliminary data concerning open label extension ahead study outlined high retention rate drug weeks production antibodies golimumab rare seems exert scarce influence drug performances conclusion golimumab appears useful well tolerated anti tnf agent
principle diode neutral point clamped three phase three level inverter neutral line analyzed mathematical model main circuit established basis operation principle oversample multi time calculation control strategy proposed reduce typical delay digital control improve system calculation accuracy lower inverter output voltage thd order improve inverter output voltage waveform logic external execution also proposed proposed control method verified kva inverter controlled microchip processor icf dsp experiment results indicated thd inverter output voltage decreased considerably
highly integrated band ghz planar phased array receiver antenna elements presented features instantaneous reception full band ghz wide two orthogonal polarizations wide scan angles using time delay instead phase shift receiver part system satellite broadcast reception board moving vehicles two sige radio frequency integrated circuits rfics developed packaged ceramic bgas assembled onto layer printed circuit board pcb integrates antenna elements outline system given along detailed description sets new standard integration density receiver extensive analog signal processing intermediate frequency level novel bipolar implementation true time delay proposed continuous programmable delay range less group delay variation ghz bandwidth wide calls constant group delay implementation chain receiver rfic consumes per channel channel gain
consider general differential inclusion parameterized parameter perform time discretization present conditions discretized solution map locally lipschitz lipschitzian modulus bounded sense show possible obtain local lipschitzian property even original discretized solution map conclude paper example concerning stability analysis nonregular electrical circuits ideal diodes
paper presents new approach determining day ahead bidding strategies large scale hybrid electric energy company company energy generation energy retailing businesses competitive electricity market demand response programs also considered retail side company order hedge risk participation wholesale market paper introduces max min bilevel mathematical programming equilibrium constraint model offering strategy manages risk uncertain forecasted rivals bids robust optimization max min bilevel model converted equivalent single level optimization using karush kuhn tucker optimality conditions duality theory utilized find equivalent ordinary maximization model max min problem strong duality theory big method also used linearize final model offering strategy applicability proposed approach shown implementing ieee bus test system
background researchers studying siblings people autism spectrum disorder asd suggest growing individual disability positive negative effects method qualitative content analysis semistructured interviews typically developing adolescents brother asd mothers used explore experience growing sibling asd identify differences relationship attitude toward brother results siblings expressed mixed feelings brother precocious sense responsibility concern future friendship difficulties troubles desire talk experience adolescents integrated positive negative feelings however adolescents displayed rejection denial sense persecution conclusions qualitative research experiences adolescent siblings people asd used develop support programs help adolescents manage relationship sibling disability
program emtp atp effective tool solving analysis transients various electrical circuits used program analysis energy stored inductance induction motor influence starting current paper deals situation repeating induction motor starting occurs immediately follow repeating induction motor starting influence already existing magnetic field motor applied caused energy stored main inductance induction motor performed simulation emtp atp made measurement
effective thermal conductivities etc vacuum computed numerically blocks open cell foams either obtained ray tomography generated computer aided design cad ideal geometries first time monte carlo random walk code accounting coupling conduction solid phase radiation pore space used whole range conduction radiation ratio parameterized nusselt number scanned law relating etc parameter obtained cases conductive radiative contributions additive slope radiative contribution etc found display distinct behavior depending whether radiation conduction dominates low temperature regime emissivity dependent etc slope high temperature regime critical ratio regimes related ratio cell strut diameters cases found etc anisotropy decreases temperature closing windows enhances conduction parallel closing walls reduces radiation perpendicular effect shown influence etc eigendirections actual media elsevier masson sas rights reserved
confirmation pregnancy viability presence fetal cardiac activity diagnosis fetal presentation head buttock maternal pelvis first essential components ultrasound assessment obstetrics former useful assessing presence going pregnancy latter essential labour management propose automated framework detection fetal presentation heartbeat predefined free hand ultrasound sweep maternal abdomen method exploits presence key anatomical sonographic image patterns carefully designed scanning protocols develop first time automated framework allowing novice sonographers detect fetal breech presentation heartbeat ultrasound sweep framework consists classification regime frame frame categorization slice video classification scores regularized conditional random field model taking account temporal relationship video frames subsequently consecutive frames fetal heart detected kernelized linear dynamical model used identify whether heartbeat detected sequence dataset predefined free hand videos covering mother abdomen straight sweep fetal skull abdomen heart detected mean classification accuracy furthermore detection heartbeat overall classification accuracy achieved authors published elsevier
geosynthetic clay liners gcls widely used hydraulic barrier along hdpe geomembrane landfills internal interface strengths gcls important evaluating landfill stability improved simple shear apparatus used study force shear failure occur along pre determined plane composite specimens fail along interface shearing gcl internally displacement component specimen also measured tests non woven geotextile side contacts textured nwgt gmx woven geotextile side contacts compacted clay layer wgt ccl dry gcl failure interface change nwgt gmx interface wgt ccl interface increases normal stresses conversely woven geotextile side contacts textured wgt gmx non woven geotextile side contacts compacted clay layer nwgt ccl dry gcl failure always occurs wgt gmx interface applied normal stresses internal failure gcl occur normal stress increased kpa gcl dry condition
study calculates rheological disease factor stain patterns blood microfluidic drop samples patients work explores programmed recognition infection specimen dried miniaturized scale drop blood stains patient pathological examination novel pathological examination proposed study less micro liters blood required strategy benefit significantly affordable low cost effortless less intrusive entirely robust disease screening infants old infection affects physical mechanical properties biological fluid blood reported many medical fluid mechanics fraternity previously thus influences specimen dehydrated blood miniaturized scale beads instance low platelet index causes drop viscosity one mechanical properties biological fluid blood due blood thinning thus blood miniaturized scale drop stain specimen utilized screening infections study proposes programmed investigation dehydrated small scale droplet blood stain specimen utilizing machine vision pattern feature extraction recognition specimens small scale drop blood stains ordinary healthy people discernible specimen miniaturized scale drop blood stains unhealthy people contextual investigation miniaturized scale drop blood stains infected contrasted small scale drop blood stains healthy noninfected people study dives fundamental fluid mechanics behind specimen dehydrated small scale drop blood stain shaped thick circular boundary dehydrated small scale drop blood stains healthy people thin crack ridge lines dehydrated small scale drop blood stains infected tuberculosis observed circular boundary microfluidic channel stream outward current conveying blood cells suspended plasma periphery concentric formed circles brought internal marangoni stream inner depositions stain patterns seen dehydrated small scale drop blood stain specimen typical noninfected people
objectives assessed effects cognitive behavioral intervention english field hockey players appraisals organizational stressors emotions performance satisfaction design concurrent across participants multiple baseline single case research design three months post intervention follow method four high level female field hockey players participated four phase intervention lasted weeks rapport building observation phase baseline monitoring phase educating players facilitating acquisition cognitive restructuring technique phase iii encouraging integration technique sport performance phase questionnaires social validation used record participants appraisals emotions performance satisfaction throughout intervention three months post intervention follow conducted assess participants retention intervention effects results reduced threat loss appraisals elevated challenge appraisals reported immediately phase iii introduced pleasant emotions performance satisfaction increased unpleasant emotions decreased throughout intervention social validation immediately post intervention end follow period indicated sustained adaptive changes outcome variables conclusions cognitive restructuring represents promising technique optimizing high level hockey players appraisals challenge appraisals pleasant emotions appear linked increased performance satisfaction positive intervention effects retained period three months post intervention researchers examine effectiveness efficacy cognitive restructuring technique populations develop robust evidence base appraisal optimization sport elsevier ltd rights reserved
operational amplifiers well known mostly used building blocks analog circuit design however due limited performance researchers look better alternatives active blocks result significant amount past going research new current mode active building blocks operational transconductance amplifiers ota second generation current conveyors ccii current feedback amps cfoa four terminal floating nullors ftfn differential voltage current conveyor dvcc differential difference current conveyor ddcc third generation current conveyor cciii dual current conveyors dxccii current controlled current conveyors cccii current differencing trans conductance amplifiers cdta etc using new active elements analog design implementing cmos technology designers acquired new possibilities solve classic opamp based problems bandwidth slew rate etc moreover active mos topologies provide solutions analog circuit design additionally usage fgmos transistors analog circuits alternative approach whose efficiency shown recently paper discusses new possibilities analog circuit design including applications communication measurement systems combining main features circuit design actual circuit realizations demonstrating several performance limitations chosen circuit examples
different researchers reported positive null negative relationships confidence accuracy reports memory one possible reason paradox variety materials used across experiments two experiments reported article show positive negative confidence accuracy correlations observed using single procedure materials subjects studied words semantic categories took recognition test making confidence ratings previously studied items positive correlations confidence accuracy obtained using three different measures yet confidence accuracy correlations assessed unstudied items studied categories correlations zero negative critical factors determining negative correlations found similarity lures presented items type analysis used results indicate one cautious relying confidence recognition rememberers must decide among highly similar events
bulimia nervosa reliably classified subtypes based dimensions dietary restraint negative affect community clinical studies shown dietary negative affect subtypes greater test retest reliability concurrent predictive validity compared subtypes based diagnostic statistical manual mental disorders dsm although dietary negative affect subtypes shown utility characterizing eating disorders involve binge eating framework may broader implications understanding restrictive eating disorders objective purpose study test concurrent predictive validity dietary negative affect subtypes among patients anorexia nervosa method latent profile analysis used identify subtypes based dimensions dietary restraint negative affect chi square multivariate analysis variance used characterize baseline differences identified subtypes structural equation modeling used test whether dietary negative affect subtypes would outperform dsm categories predicting clinically relevant outcomes results results supported profile model replicated dietary negative affect subtypes latent profile clinically elevated scores restraint latent profile elevated scores restraint negative affect validation analyses showed membership dietary negative affect profile associated greater lifetime psychiatric comorbidity psychosocial impairment compared dietary class dietary negative affect subtypes outperformed dsm categories predicting quality life impairment year follow conclusions findings highlight clinical utility subtyping based dietary restraint negative affect informing future treatment matching personalized medicine strategies
background children exposed maltreatment show neural sensitivity facial cues signalling threat however little known maltreatment influences processing social threat cues broadly whether atypical processing social threat cues relates psychiatric risk methods forty one year old children underwent social rejection themed emotional stroop task functional magnetic resonance imaging children documented history maltreatment comparison children maltreatment history groups matched age pubertal status gender socioeconomic status ethnicity reading ability classic colour stroop stimuli also administered paradigm investigate potential differences general cognitive control results compared peers children experienced maltreatment showed reduced activation rejection versus neutral condition across circuitry previously implicated abuse related posttraumatic stress disorder ptsd including left anterior insula extending left ventrolateral prefrontal cortex orbitofrontal cortex left amygdala left inferior parietal cortex sts bilateral visual association cortex encompassing cuneus lingual gyrus group differences neural behavioural responses found classic colour stroop conditions significant negative associations activity bilateral cuneus sts rejection themed stroop higher self reported ptsd symptomatology including dissociation observed children exposed maltreatment conclusion findings indicate pattern altered neural response social rejection cues maltreated children compared peers children displayed relative hypoactivation rejection cues regions previously associated ptsd potentially reflecting avoidant coping response suggested atypical processing social threat may index latent vulnerability future psychopathology general ptsd particular
new device continuous measurement fruit stem growth basis optoelectronic reflex sensor microcontroller board developed successfully tested open field conditions principle system based detection alternating narrow white blacks bars printed flexible tape tightened loop around measured object slides infrared reflex sensor response object radial growth design new sensor allows continuous long term measurements without need periodic maintenance physical adjustments measurement device new system measures changes fruit stem perimeter rather diameter thus yielding relevant information growth objects intrinsically perfectly circular cross sectional shape described sensor lightweight require mechanical frame support structure tested prototypes measurement resolution perimeter corresponding resolution diameter spherical object cost sensor modest consists inexpensive components elsevier rights reserved
present paper proposes model fuzzy logic control doubly fed asynchronous machine dfam first mathematical model dfam written appropriate reference frame established investigate results simulations order control rotor currents dfam torque tracking control law synthesized using controllers stator side power factor controlled unity level artificial intelligent controls fuzzy logic control applied simulated performances compared classical controller results obtained matlab simulink environment show fuzzy control robust superior dynamic performance hence found suitable replacement conventional controller high performance drive applications
purpose study examine efficacy abbreviated classroom based teacher taught acceptance commitment therapy act program intervention improve mental health adolescents group randomized controlled trial students age nested within classes turn nested within schools individual classes randomly assigned either four session act program usual curriculum control condition students assessed using questionnaires pre post treatment month follow questionnaires assessed quality life internalizing externalizing problems thought attention problems psychological inflexibility hierarchical linear modeling showed significant improvements outcome measures compared control group substantive effect sizes act across time observed findings failed support act format used current study abbreviated classroom based teacher taught program improve mental health students large sample many outcome variables failed find statistically significant effects substantive effect sizes study act delivered teachers opposed mental health professionals possible professionally trained therapists needed act efficacious
partial reconfiguration fpgas used dynamically extend adapt functionality computing systems swapping tasks coordinate demand task execution propose implement run time system manager rtsm scheduling software tasks available processor hardware tasks number reconfigurable regions rrs partially reconfigurable fpga fed initial partitioning application tasks corresponding task graph available task mappings rtsm controls system operation considering status task region busy idle scheduled reconfiguration execution etc rtsm supports task reuse configuration prefetching minimize reconfigurations task movement among regions efficiently manage fpga area region reservation future reconfiguration execution validate correctness portability rtsm executing image processing application two xilinx based platforms zedboard xupv also perform extensive evaluation features using simulation framework find despite technology limitations approach give promising results terms scheduling quality since rtsm supports also scheduling parallel tasks use manage execution entire parallel edge detection application desktop compare application execution time using openmp framework find rtsm execution times faster unoptimized openmp version processor affinity optimization enabled openmp rtms openmp par indicating scheduling efficiency rtsm competitive state art scheduler supporting addition management tasks
haitian study group kaposi sarcoma opportunistic infections gheskio nonprofit organization began administering antiretroviral therapy art patients practice transformed hiv fatal disease manageable chronic condition however relatively studies focus experiences survivors study provided unique opportunity interview patients survived least years treated art gheskio goal study elicit patients perspectives enabled survive aids grounded theory qualitative research method used guide data collection coding analysis individual interviews conducted audio taped transcribed analyzed creole translated english data saturation reached participants women mean age range years married completed elementary school income remaining participants incomes ranging annually qualitative analysis resulted codes grouped six categories spiritually grounded supportive interactions providers caring children setting personal goals persevering living life usual maintaining strict medication adherence practices overarching theory reason live despite one circumstances living life usual enabled one survive strong spiritual foundation coupled supportive family providers motivated participants live adhere art number patients living longer hiv haiti increases results study important helping tailor interventions enhance overall quality life
background silicosis progressive lung disease resulting inhalation respirable crystalline silica lung transplantation treatment end stage silicosis aim study analyze survival experience following lung transplantation among patients silicosis methods reviewed data patients underwent lung transplantation silicosis matched group undergoing lung transplantation idiopathic pulmonary fibrosis ipf single medical center march end december survival followed results total lung transplantations performed silicosis among lung transplantations study period observed non statistically significant survival advantage hazard ratio undergoing lung transplantation silicosis relative ipf patients undergoing lung transplantation period conclusions within limits small sample survival silicosis patients following lung transplantation reduced compared ipf ind med wiley periodicals inc
elliptic curve cryptosystems proved well suited securing systems constrained resources like embedded portable devices fault based attack errors induced computation cryptographic primitive results collected derive information secret key safely stored device introduce novel attack methodology recover secret key employed implementations elliptic curve digital signature algorithm attack exploits information leakage induced altering execution modular arithmetic operations used signature primitive rely underlying elliptic curve mathematical structure thus applicable standardized curves provide validation feasibility attack even employing common shelf hardware perform required computations low cost countermeasure counteract
purpose mathematical complexity brillouin function makes unsuitable calculations application difficult computer programming magnetism approximation tanh function proposed ease mathematical operations cases approximation works good accuracy acceptable practical calculations approximation already formed foundation hyperbolic model magnetism study hysteretic phenomena reversal brillouin function important difficult mathematical problem practical purposes proposal put forward easy approximation using analytical expression provides good workable solution function dependent angular momentum quantum number material used proposed approximation applicable within working range practical applications paper aims discuss issues design methodology approach multi variant brillouin function closely approximated tanh function ease calculations mathematically unsolved reversed function approximated simple analytical expression good working accuracy findings brillouin function reversal approximated practical users mostly professionals working magnetism research limitations implications practical problems magnetism solved within limitations two approximations practical implications proposed functions ease mathematical problems faced researchers users magnetism social implications ease frustration users working field magnetism originality value application tanh function replacing brillouin function led creation hyperbolic model hysteresis author knowledge reverse function mathematically solved vastly complicated mathematics hardly suitable practical calculations magnetism proposed simple expression useful theorists experimental scientists
flexible cartesian manipulator coupling system moving rigid body flexible structures thus vibration suppression problem must solved guarantee stability control accuracy characteristic model based nonlinear golden section adaptive control cmngsac algorithm implemented suppress vibration flexible cartesian smart material manipulator driven ballscrew mechanism using servomotor system modeling derived recognize dynamical characteristics closed loop stability analyzed based model also experimental setup constructed verify adopted method experimental comparison studies conducted modal frequencies identification active vibration control flexible manipulator active vibration control experiments include set point vibration control responses vibration suppression resonant excitation simultaneous translating vibration suppression using different control methods experimental results demonstrate controller suppress larger lower amplitude vibration near equilibrium point effectively elsevier ltd rights reserved
article systematically reviews studies exploring resilience among youth experiencing homelessness searched eight databases articles fit inclusion criteria represented four methodologies qualitative survey secondary data analysis quantitative mixed method designs studies indicate youth experiencing homelessness rely informal social networks survival spirituality mental health creativity associated enhanced coping experimental intervention studies necessary support evidence based resilience practices additionally researchers need exercise self awareness stereotypical pejorative paradigms may constrain innovative strengths based scholarship
children represent population risk short size naivety attraction animals face hands specific locations young children wounds often multiple half cases child knows animal dogs cats frequency argument bite episode occurs mostly child alone pet without direct supervision playing stroking animal bites pediatric lesions infectious functional aesthetic emergencies goal work primarily make point principles surgical management animal bites children highlighting pediatric specificities animal bites require psychological anesthetic surgical treatment adapted child specialized structure hospitalization general anesthesia frequent children suspicion mistreatment abuse lead child hospitalization even wounds justify monitoring surgical environment emergency surgery essential limit functional aesthetic consequences healing capacities child frequent lack morbidity allow conservative surgical treatment suture repositioning skin flaps controlled healing first place immobilization drainage antibiotics complete surgery healing process however leads specific management scar remodeling phase growth psychological care child parents forgotten start time surgical treatment acute phase elsevier masson sas rights reserved
homelessness major public health problem received considerable attention clinicians researchers administrators policymakers recent years individuals homeless united states department housing urban development individuals united states experiencing homelessness month sometime lives experiencing homelessness last year tsai homelessness remains recalcitrant problem ripe area study particularly addressing needs individuals high risk homelessness understudied populations new innovative measurement approaches interventions study methodologies presented special issue shed light psychology help benefit improve homeless services
mycosis fungoides characterized switch indolent behaviour early stages worse clinical outcome advanced ones recently various studies investigated role microenvironment might play switch analysed distribution langerhans cells plasmacytoid dendritic cells myeloid derived suppressor cells cases various stages aiming assess whether changes occur early advanced stage investigated number langerin arginase positive cells distribution high power data analysed using test continuous variables chi tests fisher exact test categorical variables well analysis covariance comparing stages iib observed significant decrease langerhans cells value significant increase arginase positive cells value markers furthermore significant increase langerhans cells observed stage iib comparison stage iii stage significant decrease langerhans cells noted comparison stage iii data suggest changes microenvironment might influence disease progression especially stages iib opening new scenarios therapy
past decades characterized exponential growth knowledge advances clinical treatment atrial fibrillation known genesis requires vulnerable atrial substrate formation composition substrate may vary depending comorbid conditions genetics sex factors population based studies identified numerous factors modify atrial substrate increase susceptibility date genetic studies reported independent signals genomic regions studies established advanced age male sex european ancestry prominent risk factors modifiable risk factors include sedentary lifestyle smoking obesity diabetes mellitus obstructive sleep apnea elevated blood pressure predispose factor shown induce structural electric remodeling atria heart failure myocardial infarction increase risk vice versa creating feed forward loop increases mortality cardiovascular outcomes attributed including stroke thromboembolism well established epidemiology studies championed therapeutics mitigate adverse outcomes however role anticoagulation preventing dementia attributed less established review comprehensive examination epidemiological data associating unmodifiable modifiable risk factors pathophysiological evidence supporting mechanistic link risk factor genesis review also critically examines epidemiological data clinical outcomes attributed summarizes current evidence linking outcome
orthorexia recognized eating disorder obsessive compulsive spectrum disorder somatoform disorder aim research analyze nutritional behaviors assessment risk orthorexia authors developed questionnaire respondents participated used research method men women ate mostly meals per day women versus men however men women ate meals daily men versus women place birth field study differ terms number meals moreover observed number meals per day correlated declared time spent planning diet people ate meals per day often indicates spent per day planning diet comparison people ate meals respondents declared often ate meals company someone whereas indicated rule remaining respondents often consumed meals alone almost twice many men women never paid attention qualitative composition nutrition women followed slimming diet often men versus indicated attempts losing weight around one third respondents suffered suffer eating disorders owing insufficient information orthorexia essential conduct research determine characteristics high risk groups taking growing interest healthy lifestyle account need address problem orthorexia public space
background emergency contraception known several decades dedicated products market close years yet unclear whether women particularly low resource countries access important second chance method contraception objectives review relevant policies regulations factors related access emergency contraception worldwide search strategy wide range gray literature reviewed several specific studies commissioned number online databases searched main results several positive policies regulations place emergency contraception products registered majority countries around world listed many countries essential medicines lists included widely used guidance supported donors yet analysis demographic data shows majority women low income countries never heard emergency contraception surveys find many providers negative attitudes toward providing emergency contraception conclusions despite decade concerted international country level efforts ensure women access emergency contraception accessibility remains limited international federation gynecology obstetrics published elsevier ireland ltd rights reserved
agents agent systems becoming important development variety fields ubiquitous computing ambient intelligence autonomous computing intelligent systems intelligent robotics paper analyze agent technology presented mathematical models computation demonstrating models used novel distributed intelligent managed element dime network architecture dna extends conventional computational model information processing networks allowing improvement efficiency resiliency computational processes
boost converters indirect energy transfer topologies fastest transient response usually coincide minimum possible output voltage deviation paper introduces practical mixed signal current programmed mode cpm controller compared time optimal solutions provides smaller deviation lower current stress simpler controller implementation recover transients controller passes two phases first phase inductor current set proximity steady state value initial transient caused capacitor charging discharging process reversed second phase voltage gradually recovered controller implements simple algorithm setting inductor current output voltage peak valley values transients based output current estimate obtained self tuning procedure operation controller verified simulations experimentally boost based prototype operating khz switching frequency comparison time optimal controller shows introduced programmable deviation system results times smaller voltage deviation limiting component stress
every day people interested learning computer science either improve skill set apply new jobs personal growth sector population looking instruction subjects increased diversified need new tools appeal wider audience game based learning one promising approaches moment need scalable game based instruction paradigms easily adapted different levels complexity content related different programming languages different programming paradigms throughout paper present flexible scalable architecture create videogames learning languages architecture based idea students control game using small pieces text written language keys scalability approach separates language used write programs game design game model provides system levels allows incremental learning language structures validation implementation approach developed lost space educational videogame teach xml markup language game player travels several levels guiding spaceship introducing small pieces xml text console players move rotate ship among power ups get unblocked advances game game tested undergraduate students social sciences comparing traditional instruction teacher slides presentation students played game much engaged attended lecture showing active attitude throughout whole experience also spent time practicing class findings also suggest game effective instruction regardless background students however educational gain observed game based instructional approach although effective significantly higher traditional instruction think approach adequate introduce languages general well new programming languages seems appealing new comers traditional instruction
background limited data available regarding cost firefighter injuries information necessary develop targeted injury prevention strategies objective categorize cost injuries filed firefighters large department job duty injury type body part affected general motion pattern employed time injury methods data taken reports filed cfd personnel claims filed workers compensation board wcb alberta january december results injuries reported categorized sprains strains frequent affected back total cost claims sprain strain related knee back injuries costly categorized job duty sprains strains sustained attending fire station responsibilities although physical training associated highest costs fireground operations attributed sprains strains costs lifting injuries frequent costly injuries conclusions common costly injuries occurred attending fire station related responsibilities physical training
context lactation causes delay ovulation postpartum period therefore delay resumption menses however return fertility variable postpartum period contingent upon numerous factors postpartum period therefore critical time initiate effective contraception order support numerous beneficial health outcomes optimal pregnancy spacing breastfeeding women unmet need highly effective birth control methods interfere lactation safe infants progesterone releasing vaginal ring pvr releases natural progesterone suppresses ovulation specifically designed breastfeeding women first postpartum year objective review published peer reviewed literature regarding safety effectiveness pvr used contraception among lactating women well safety infants results review informed decisions guideline development group include recommendations contraceptive eligibility pvr within world health organization medical eligibility criteria contraceptive use edition methods searched pubmed popline lilacs bibliographic databases articles published language database inception october reviewed literature evidence regarding safety pvr among breastfeeding women using method well infants preventive services task force system applied assess quality evidence results seven articles met criteria inclusion review studies prospective cohort design studies consistently showed use pvr among breastfeeding women compares favorably methods contraception regard effectiveness compromise woman breastfeeding performance adversely affect infant growth first year postpartum conclusion pvr safe highly effective method contraception use among breastfeeding women offered women plan breastfeed context postpartum contraceptive counseling published elsevier inc
small interfering rnas antisense oligonucleotides asos simplicity reasons referred oligonucleotides small synthetic rna dna molecules sequence complementary pre mrna although basic mechanisms action sirnas aso distinct sequence specific interaction oligonucleotides target pre mrna alters target fate includes highly effective sequence specific blockade translation consequently depletion corresponding protein number years oligonucleotides used tool biological research study gene function vitro recently safe specific delivery oligonucleotides liver mammals achieved optimized allowed use vivo gene studies physiology disease also opened opportunity development new generation rna specific drugs therapeutic purposes first oligonucleotide product targeting rna hepatic cholesterol pathway approved blood coagulation large portion key proteins produced liver thereby sirnas asos also used appropriate tools target proteins vivo review describe first use oligonucleotides purpose zebrafish primates use oligonucleotides allows avoidance early lethality associated full deficiency several coagulation factors proved value studying proteins physiology disease currently oligonucleotides tested therapeutics ultimate goal beneficially modulate hemostatic balance thrombosis hemophilia patients discuss preclinical clinical studies number sirnas asos potential introduced drugs prophylactic treatment thrombosis hemophilia conclude coagulation field oligonucleotides value research purposes moment come fulfill promise therapeutics
background preterm infants immature skin contributes skin problems little known postnatal changes skin despite clinical importance issue aim assess temporal changes skin water content preterm infants study design prospective observational study subjects infants admitted neonatal intensive care unit included study outcome measures skin water content measured five different skin regions using dielectric methods depth skin water content measured postnatal day infants correlation skin water content gestational week analyzed measurements also made postnatal days every days thereafter corrected age weeks infants temporal changes statistically analyzed dividing participants seven groups gestational age results postnatal day skin water content correlated inversely gestational age skin regions skin water content decreased significantly time converging level term infants corrected age weeks conclusions skin water content depth related corrected age reached level term infants corrected age approximately weeks elsevier ireland ltd rights reserved
objectives study assess within person hypotheses regarding temporal cognition pain associations morning pain flares predict changes two afternoon adaptive maladaptive pain related cognitions changes afternoon cognitions predict changes end day pain reports turn carry predict next morning pain individuals fibromyalgia two hundred twenty individuals fibromyalgia completed electronic assessments pain intensity pain catastrophizing pain coping efficacy three times day three weeks multilevel structural equation modeling established afternoon catastrophizing coping efficacy parallel mediators linking late morning end day pain reports controlling afternoon pain line prediction catastrophizing stronger mediator coping efficacy moreover afternoon cognitions end day pain reports served sequential mediators relation day next day morning pain findings align assertions cognitive behavioral theories pain pain flares predict changes pain adaptive maladaptive cognitions turn predict changes pain
study carried investigate heat transfer characteristics peristaltic flow oldroyd constant curved channel inertial streamline curvature effects negligible solution resulting nonlinear governing equations obtained using finite difference technique fdm combined iterative scheme impacts physical parameters flow heat transfer characteristics investigated detail particular attention given explain pumping trapping phenomena detail comparative study curved straight channels also made found rate heat transfer increases increasing curvature channel current two dimensional analysis applicable bio fluid mechanics industrial fluid mechanics engineering fields elsevier ltd rights reserved
circadian rhythms daily rhythms regulate many biological processes gene transcription behavior disruption rhythms lead myriad health risks circadian rhythms entrained light oscillation maintained core molecular feedback loop composed canonical circadian clock genes proteins different modulators help maintain proper rhythmicity genes proteins one emerging modulator dopamine dopamine shown circadian like activities retina olfactory bulb striatum midbrain hypothalamus regulates regulated clock genes areas thus likely dopamine essential mechanisms maintain proper rhythmicity five brain areas review discusses studies showcase different dopaminergic mechanisms may involved regulation brain areas circadian rhythms mechanisms include dopamine dopamine receptor activity directly indirectly influence clock genes proteins dopamine interactions gap junctions influence daily neuronal excitability dopamine release effects gated low high pass filters dopamine neurons described review also release inhibitory neurotransmitter gaba influences clock protein expression retina discuss articles explore gaba may contribute actions dopamine neurons circadian rhythms finally understand loss function dopamine neurons could influence circadian rhythms review studies linking neurodegenerative disease parkinson disease disruptions circadian rhythms five brain areas purpose review summarize growing evidence dopamine involved regulating circadian rhythms either directly indirectly brain areas discussed appreciation growing evidence dopamine influence circadian rhythms may lead new treatments including pharmacological agents directed alleviating various symptoms circadian rhythm disruption
rosiglitazone thiazolidinedione peroxisome proliferator activated receptor gamma ppar gamma agonist increases insulin sensitivity documented side effect diabetes drug increased appetite although mechanism mediating response unknown better understand effects food intake regulation evaluated appetite associated effects rosiglitazone alternative vertebrate agriculturally relevant model domesticated chick four day old chicks received intracere broventricular icv injections nmol rosiglitazone food water intake measured chicks received nmol rosiglitazone increased food intake observation period effect water intake next experiment chicks icv injected nmol rosiglitazone hypothalamus collected post injection total rna isolation real time pcr performed measure mrna abundance appetite glucose regulation associated factors neuropeptide npy proopiomelanocortin pomc mrna decreased npy receptor npyr mrna increased rosiglitazone injected chicks compared controls results show central effects rosiglitazone appetite conserved birds mammals increases food intake might mediated npy pomc neurons hypothalamus elsevier inc rights reserved
purpose study draws social comparison theory explore circumstances individuals receiving idiosyncratic deals deals likely help workers design data collected alumni association engineers participants completed two questionnaires time findings find relationship deals helping behavior direct mediated organizational based self esteem relationship stronger deal recipients believe workers opportunity get deals implications deal recipients expected help colleagues helping colleagues consistent positive self developed thanks deals workers opportunity get deals social comparison deal recipient colleagues likely salient strengthen indirect relationship deal helping behavior originality study tests deals vantage point social comparison theory rather perspective social exchange thereby provide richer account complexities involved helping behavior exploring contextual variables likely trigger social comparisons also expect better understand circumstances deals likely associated helping behavior
relationship facial shape attractiveness extensively studied yet studies investigated underlying biological factors attractive face many researchers proposed link female attractiveness sex hormones little empirical evidence support assumption present study investigated relationship circulating sex hormones attractiveness created prototypes separately averaging photographs women high low levels testosterone oestradiol testosterone oestradiol ratio levels respectively independent set facial images shape transformed toward prototypes paired resulting images way one face depicted female high hormone level one low hormone level fifty participants asked choose attractive face pair found low testosterone oestradiol ratio low testosterone positively associated female facial attractiveness preference faces high oestradiol levels additional experiment participants confirmed low testosterone oestradiol ratio plays larger role low testosterone alone results provide empirical evidence attractive female face shaped interacting effects testosterone oestradiol
objectivesto investigate whether higher serum microglobulin levels kidney function marker associated prevalent incident frailty community dwelling older women designcross sectional longitudinal analyses prospective cohort settingpopulation based cohort study tokyo japan participantscommunity dwelling women aged older adequate data assessing frailty status subset participants without baseline frailty repeated frailty assessment years follow measurementsthe primary predictor level outcomes prevalent incident frailty year follow period frailty defined presence three five fried criteria weight loss exhaustion weakness slowness low physical activity adjusted odds ratios main confounders obtained using logistic regression discrete time cox proportional hazards models used determine risk developing frailty resultsthe study included women prevalent frailty baseline incident frailty year follow multivariate analysis adjusted multiple potential confounders odds prevalent frailty times great levels levels less times great levels unadjusted model levels associated greater incidence frailty levels less hazard ratio confidence interval multivariate analysis adjusted potential confounders significant association noted highest quartile incident frailty conclusionhigher levels independently associated greater frailty baseline older adults slightly associated greater risk incident frailty years follow
introduction juvenile idiopathic arthritis jia common chronic rheumatic disease childhood improvement knowledge pathogenetic mechanisms jia advances understanding pathways linking inflammation autoimmunity functions multiple transcription factors translated new drug development tailored treatment directed specific subpopulations jia patients areas covered review provides digest new investigational drugs currently recently tested treatment jia highlights early phase clinical trials rilonacept givinostat daclizumab tofacitinib sarilumab expert opinion several studies focused multiple complementary pathways driving synovial inflammation jia molecules implicated inflammatory signature jia deliver durable effects prevent long term complications since jia complex disorder multiple faces identifying new treatment options patients nonresponsive current drug armamentarium great relevance number agents developed last years givinostat tofacitinib showing promising results cases trials remain early phase agents currently evaluation phase setting longer term use possibly high numbers patients adequate data collection using large scale registries necessary confirm clinical efficacy provide well balanced overview safety issues related drugs presented review
background erythropoietin epo part endogenous neuroprotective system brain may address pathophysiological mechanisms progressive multiple sclerosis objective evaluate treatment effect epo progressive methods single center randomized double blind placebo controlled phase trial patients secondary primary progressive allocated treatment recombinant epo placebo administered intravenously times weeks patients expanded disability status score edss clinical progression without relapses preceding years primary outcome change composite measure maximum gait distance hand dexterity cognition baseline weeks results total patients completed study venesection performed often thromboembolic events occurred found difference primary outcome epo placebo group using intention treat principle none secondary outcomes neither clinical magnetic resonance imaging mri measures showed significant differences conclusion study provides class evidence treatment high dose epo effective treatment patients moderately advanced progressive
paper presents systematic design approach synthesize feasible configurations parallel transmissions hybrid electric vehicle using single electric motor generator based studies existing parallel hybrid systems four main types parallel hybrid transmissions classified studied mechanisms studied present research two degrees freedom compound planetary gear trains consisting two simple planetary gear trains applying proposed design approach twelve feasible mechanisms parallel hybrid transmissions generated four potential mechanisms used existing designs employed systematically synthesize corresponding feasible parallel hybrid transmissions including existing parallel systems demonstrate feasibility synthesized systems new parallel hybrid transmission taken arbitrarily numerical example illustrate working principle operation modes kinematics power flow analysis elsevier ltd rights reserved
background within international rugby union injury rates rugby world cup reported therefore injury rates types international tournaments unknown purpose assess year incidence severity nature causes match training injuries sustained different international tournaments played welsh national rugby union team study design descriptive epidemiology study methods injury data players selected national rugby union team year period analyzed using international consensus statement methods player height mass recorded tournaments grouped comparisons autumn tournaments rugby world cup rwc six nations summer tournaments injury incidence injuries hours prevalence players unavailable severity days lost calculated tournament injury location type cause match training injuries analyzed results match injury incidence highest autumn tournaments match hours lowest rwc match hours summer tournaments highest training incidence injuries training hours mild injuries likely rwc risk ratio severe injuries likely autumn tournaments quadriceps hematomas match hours concussions match hours common match injuries shoulder dislocations severe mean days lost per injury conclusion injury rates considerably higher previously reported multiple teams rwc tournaments investigation injury rates risk factors recommended accurately gauge impact within international rugby union particularly regard lower limb hematoma concussion shoulder injuries
endolichenic fungus apiospora montagnei isolated lichen cladonia cultured solid rice medium yielding new diterpenoid libertellenone new pyridine alkaloid acetyl nhydroxyapiosporamide new xanthone derivative hydroxy hydroxymethyl oxo hxanthene carboxylic acid methyl ether together known compounds structures new compounds elucidated nmr spectra well hresims data absolute configuration new seco libertellenone derivative determined single crystal ray diffraction four additional known compounds isolated naci nhci added solid rice medium compounds exhibited significant cytotoxicity murine lymphoma cell line values respectively elsevier ltd rights reserved
automated environmental compliance checking requires automated extraction rules environmental regulatory textual documents energy conservation codes epa regulations automated rule extraction requires complex text processing analysis information extraction subsequent formalization extracted information computer processable rules proposed automated compliance checking acc approach text first classified predefined categories information extraction advantages irrelevant text filtered text classification text similar semantic meaning grouped thereby improving efficiency accuracy compliance reasoning categories used predefined semantic topic hierarchy classified text subsequently used semantic semantic paper presents proposed machine learning based algorithm classifying clauses environmental regulatory documents based topic hierarchy developing algorithm different text preprocessing techniques algorithms performance improvement strategies tested used final algorithm tested environmental regulatory documents evaluated terms precision recall algorithm achieved approximately average recall precision respectively testing data
conclusion present study confirms correlation chronic cerebrospinal venous insufficiency ccsvi diagnosis meniere disease ccsvi could considered new ultrasound vascular pattern cerebrospinal venous system patients affected definite conversely present results showed ccsvi considered pathogenic mechanism idiopathic sudden sensorineural hearing loss issnhl objectives aim study investigate correlation ccsvi evaluate ccsvi considered risk factor also issnhl moreover study seeks establish even different timing onset natural history issnhl may share common pathogenic mechanism method one hundred eighty two patients affected definite patients affected issnhl healthy control patients enrolled study subjects underwent echo color doppler ecd cerebrospinal venous flow results one hundred fifty two patients affected definite patients affected issnhl positive ccsvi ecd examination cerebrospinal venous flow healthy control group consisted subjects showed positivity ccsvi
background migraine prevalent disorder characterised recurrent headache attacks preceded accompanied aura subgroup patients migraine often occurs together major depressive disorder mdd alterations adipokine levels reported migraine mdd cross sectional study aimed assess associations serum leptin adiponectin levels migraine migraine subtypes analyses adjusted lifetime history mdd order investigate association adipokines migraine consideration depression status methods included participants colaus psycolaus study impact leptin adiponectin levels diagnosis migraine analysed binary regression analyses adjusting variables known influence adipokine levels subgroup analyses conducted based presence aura results crude leptin levels significantly higher subjects migraine controls mann whitney performing adjusted analyses leptin levels found significantly higher subjects migraine odds ratio migraine aura odds ratio conclusion high leptin levels might play role pathogenesis migraine migraine aura
caffeine major purine alkaloid tea long known role plant defense however effect colletotrichum gloeosporioides causes brown blight disease tea largely unknown especially elevated show elevated reduced endogenous caffeine content tea leaves sharply increased susceptibility tea gloeosporioides expression gloeosporioides actin gene gradually increased postinoculation period contrast foliar application caffeine decreased gloeosporioides induced necrotic lesions expression gloeosporioides actin analysis endogenous jasmonic acid content revealed exogenous caffeine could induce content conditions absence fungal infection however presence fungal infection caffeine increased content elevated furthermore exogenous caffeine enhanced lipoxygenase lox activity biosynthetic gene expression conditions indicating increased biosynthesis via lox pathway caffeine might strengthen plant defense elevated caffeine induced defense ambient might associated independent lox pathway tea results provide novel insights caffeine induced plant defense mechanisms might help develop eco friendly approach disease control
adhesively bonded joints found important application areas marine offshore industry last years one particular application use bonded patches repair steel structures floating production storage offloading units fpsos experience shown fpsos develop corrosion cracks service welding frequently applied repairing kinds defects hot work allowed fpsos production closing production expensive thus composite patch repair using adhesives attractive alternative means need investigate strength bonded steel composite joints present paper strength adhesively bonded lap shear joints studied failure loads obtained experimentally presented compared theoretical predictions capacity estimates provided traditional strength materials approaches agree experiments hand results obtained recent inelastic fracture based analysis represent measured strength values well furthermore finite element analysis using cohesive elements adhesive bondline shown powerful tool strength predictions adhesively bonded joints addition provide accurate estimates ultimate failure loads fracture process modelled analysis method applicable wide range joint geometries elsevier ltd rights reserved
worldwide upward trend obesity dramatic affecting american women reproductive age obesity associated many adverse maternal fetal effects prenatally also exerts negative influence female fertility obese women likely ovulatory dysfunction due dysregulation hypothalamic pituitary ovarian axis women polycystic ovarian syndrome also obese demonstrate severe metabolic reproductive phenotype obese women reduced fecundity even eumenorrheic demonstrate poorer outcomes use vitro fertilization obesity appears affect oocyte preimplantation embryo disrupted meiotic spindle formation mitochondrial dynamics excess free fatty acids may toxic effect reproductive tissues leading cellular damage chronic low grade inflammatory state altered levels adipokines leptin obese state affect steroidogenesis directly affect developing embryo endometrium also susceptible evidence impaired stromal decidualization obese women may explain subfecundity due impaired receptivity may lead placental abnormalities manifested higher rates miscarriage stillbirth preeclampsia obese population many interventions explored mitigate effect obesity infertility including weight loss physical activity dietary factors bariatric surgery data largely mixed high quality studies guide improve understanding pathophysiology obesity human reproduction hope identify novel treatment strategies american society reproductive medicine
article describes methods calculation slopes fortified geotextile framework plastic systems marginal analysis continuous anisotropic medium shift resistance taken experiments theoretical values bearing capability compared experimental values obtained tray modeling experiments bearing capability calculating algorithm artificial reinforced embankment presented computer software example tray experiments similarity conditions maintained geosynthetics modeling material characteristics defined experiments medium grained sand used base air dry state experimental values load limit correspond estimated load values gained sample results work used engineering practice calculate artificial earthwork structures reinforced geosynthetics first limiting state ultimate limit states authors published elsevier ltd
background regular sleep schedules important part healthy sleep habits although television viewing associated altered sleep patterns sleep disorders among children adolescents effect television viewing sleep patterns infants toddlers known objective test hypothesis television viewing infants toddlers associated irregular naptime bedtime schedules methods used data national survey early childhood health nationally representative cross sectional study health health care children months age main outcome measures whether children irregular naptime bedtime schedules main predictor hours television watched daily basis performed multivariate logistic regression analyses adjusting variety factors including demographic information measures maternal mental health measures family interactions test independent association television viewing irregular naptime bedtime schedules results data available children thirty four percent children irregular naptime schedules irregular bedtime schedules mean hours television viewing per day follows hours day confidence interval hours day children months age hours day hours day children months age hours day hours day children months age logistic regression model number hours television watched per day associated irregular naptime schedule odds ratio irregular bedtime schedule odds ratio conclusions television viewing among infants toddlers associated irregular sleep schedules research warranted determine whether association causal
design integrator based filters degrees freedom selection signal flow graph representing connection state integrator paper procedure proposed selecting signal flow graph filter small deviation ideal frequency characteristics general integrator works ideally near unit gain frequency hence older realize filter excellent characteristics guideline described selecting signal flow graph unit gain frequencies integrators used filter close since amount computation selection signal flow graph becomes enormous even filter low order evaluation scale search used easily estimate spread unit gain frequencies individual signal flow graphs examples signal flow graphs derived fifth order maximally flat delay low pass filter third order amplitude equal ripple low pass filter validity proposed evaluation scale presented effectiveness design guideline confirmed computer simulation filter made mosfet based obtained signal flow graphs scripta technica
background glenoid bone loss affect outcome treatment posttraumatic recurrent anterior glenohumeral instability clinical presentation adolescent age group shoulder instability glenoid bone loss largely unknown basis information believe high incidence glenoid bone loss adolescent patients recurrent glenohumeral instability hypothesize highimpact injuries sports injuries reductions requiring sedation factors associated glenoid bone loss methods performed retrospective cross sectional cohort study reviewing consecutive adolescent patients recurrent traumatic glenohumeral instability chart analysis included demographic presenting radiographic data glenoid bone loss interpreted plain radiographs computed tomography magnetic resonance imaging arthroscopy compared possible risk factors subjects without glenoid bone defects using test sample tests results glenoid bone loss seen patients patients critical bone loss forty five percent appreciated glenoid bone loss visualized plain radiographs average age years range male female ratio male sex older age taller stature statistically associated glenoid bone loss respectively primary dislocations occurred sports likely glenoid bone loss presence apprehension sign physical examination positively correlated bone loss conclusions presence glenoid bone loss primary traumatic glenohumeral instability adolescent population high however high previously reported factors associated glenoid bone loss include male sex older age taller stature sports injuries presence apprehension physical examination level evidence study establishes patients may high risk glenoid bone loss based mechanism injury physical examination findings prognostic study level retrospective study
pulmonary fibrosis progressive often fatal condition believed partially orchestrated macrophages mechanisms control migration cells within lung remain undefined evaluated contributions semaphorin receptor plexin plxnc exocytic calcium sensor synaptotagmin syt processes evaluated role plxnc macrophage migration using boyden chambers scratch tests characterized contribution experimentally induced lung fibrosis mice defined mechanism observations findings reveal relative control participants patients idiopathic pulmonary fibrosis demonstrate excessive monocyte migration underexpression plxnc lungs circulation finding recapitulated setting scleroderma related interstitial lung disease relative wild type plxnc mouse macrophages excessively migratory plxnc mice show exacerbated collagen accumulation response either inhaled bleomycin inducible lung targeted tgf beta overexpression findings ameliorated replacement plxnc bone marrow derived cells genetic deletion syt data demonstrate previously unrecognized observation plxnc deficiency permits syt mediated macrophage migration enhances mammalian lung fibrosis
continuous valued number system novel number system employed developing analog signal processing units continuous number system represented set continuous digits one main features system digits share information digit level redundancy redundancy used protect digits environment imperfections implemented analog circuits paper integrity number system representing real values explored study required show effect implementation imperfections indicative feasibility effects possible errors error threshold implementing system studied paper error recovery method proposed enhances number system representation efficient error recovery method extends application number system high density memory storage devices hardware implementations neural networks
lung sensitization asthma main health effects methylenediphenyl diisocyanate mdi albumin adducts isocyanate specific adducts mdi might involved etiology sensitization reactions albumin adducts mdi analyzed sera diisocyanate exposed worker without diisocyanate occupational asthma well exposed workers without diisocyanate specific igg antibodies positive workers igg positive workers albumin adducts significantly higher versus workers without specific igg negative odds ratio positive times larger workers adduct levels fmol odds ratio igg positive times larger workers adduct levels fmol therefore albumin adducts appear good predictor biological effects albumin adduct levels workers without biological effects range adduct levels found previous studies healthy mdi factory construction site workers
internal combustion engines technology choice propulsion decentral power supply last century due high energy density hydrocarbon based fuels could far reached alternative technologies keep leading role applications next decades although general functionality seems unchanged since invention internal combustion engine gone substantial developments driven various challenges within pollution control named first due role main driver engine aftertreatment development since discussions air quality started years ago meanwhile industrialized countries emerging countries less stringent regulations main harmful exhaust components nox particulates second main challenge named reduction emissions various engine technologies currently used tackle global trends lead major impact exhaust aftertreatment components tackle challenges exhaust aftertreatment development understood integrated multi disciplinary multi scale design process considering engine design operation board diagnosis aftertreatment design operation likewise
backgrounda subset patients chronic constipation display relatively high manometric rectal pressure strain hypothesized patients represent unique phenotype functional defecatory disorder fdd would benefit undergoing anorectal biofeedback methodsof consecutive patients chronic constipation symptoms fdd defined high rectal pressure strain using statistically derived cut subset compared remaining patients regard baseline clinical profile physiology outcome key resultsthere greater representation males high rectal pressure group constipation score impact bowel dysfunction quality life satisfaction bowel habits differ remaining patients eighty four percent patients high group successfully expelled rectal balloon displayed paradoxical anal contraction strain compared remaining patients following patients high group reduced rectal pressure normal end treatment outcomes improved significantly similar degree groups conclusions inferenceswe identified subgroup patients dyssynergic symptoms without formal rome iii diagnosis fdd characterized high straining rectal pressure although patients displayed physiological differences patients lower straining rectal pressure suffer similarly importantly shown patients respond favorably anorectal
phase shift control effectively avoid soliton interactions symbolic computation hirota bilinear method analytic studies made nonlinear schrodinger equation used describe propagation solitons dispersion decreasing fibers analytic two soliton solutions obtained obtained solutions variable group velocity dispersion function dispersion decreasing fibers gaussian one phase shift control achieved soliton interactions avoided pulse quality optical communication systems improved moreover influences parameters dispersion decreasing fibers phase shift control discussed results also helpful logic gates optical switches
role women romanian society undergone changes time image female characters commercials running national channels suffered process diversification accordance view television primary storyteller viewed important agent socialization stories appear news reality programs dramas etc last least commercials multiple layers perception overlap thus potential consumers left develop meanings present paper intended semio stylistic analysis relevant commercials appearing romanian channels period aim identifying gender roles way exist general perception dichotomy masculine feminine romanian society
utilization ontologies knowledge management become well accepted many approaches instance database semantics agent natural language processing etc artificial intelligent researchers originally applied word ontology philosophy fields means existence word spread many scientific domain ontologies used several developments purpose research present simple methodologies methods used build adapt integrate ontologies system requirement reusing engineering ontologies also process merging approach addressed normal ontology engineering suitable non expert user tools helping user accomplish ontology engineering task however simple paper mentioned observation figure practical methodology non expert user learn create simple ontology little background paper mentioned ontology ontology engineering revisits also main section paper mentioned scenario walkthrough reality non expert user creates simple ontology using suggested existing methodologies last section recommendation suggestion research experimental explain proper ontology developing methodology non expert user
investigate short term non linearity solar irradiance fluctuations using multifractal detrended fluctuation analysis mfdfa mfdfa shows time series solar irradiance long range correlation function multifractal behavior apply method solar irradiance time series several regions around world resolutions seconds minutes obtained generalized hurst renyi exponents tau suggest non linear non stationary essence measured irradiance time series also analyze shuffled random phase rank wised surrogated data reveal nature multifractality conclude linear non linear correlations dominant contributions observed multifractal non linear behavior solar irradiance elsevier ltd rights reserved
access family planning identified critical public health improving linkage medical social services could result improved access care risk unintended pregnancy study used survey based alfred bandura social cognitive theory increase understanding barriers social workers confront provision family planning information clients although moral disagreement family planning presented barrier workplace policy participation family planning trainings working urban setting greater value understanding barriers
sacubitril valsartan lcz first angiotensin receptor neprilysin inhibitor approved reduce cardiovascular mortality hospitalization patients heart failure reduced ejection fraction neprilysin nep one several enzymes known degrade amyloid beta beta theoretical risk beta accumulation following long term nep inhibition primary objective study evaluate potential effects sacubitril valsartan central nervous system clearance isoforms cynomolgus monkeys using sensitive stable isotope labeling kinetics silk beta methodology vitro selectivity valsartan sacubitril active metabolite sacubitrilat established sacubitrilat inhibit human beta degrading metalloproteases week study sacubitril valsartan day vehicle orally administered female cynomolgus monkeys conjunction silk beta despite low cerebrospinal fluid csf brain penetration csf exposure sacubitril sufficient inhibit nep resulted increase elimination half life beta beta beta total acutely returned normal expected repeated dosing days csf concentrations newly generated beta auc indicated elevations aggregable form beta day day shorter forms beta beta beta total day however elevations beta isoforms brains monkeys day second study cynomolgus monkeys administered sacubitril valsartan vehicle control weeks microscopic brain changes beta deposition assessed immunohistochemical staining present clinical studies planned address relevance findings authors published elsevier inc
paper method modelling dynamics electronic discussions proposed based three parameter model known modern control engineering knowledge model points possibility estimating dynamic movements discussions well understanding designing maintaining guidance several thousands real discussions processed
main focus paper select economically suitable sustainable standalone power supply system remote grid town western australia existing power systems remote towns australia adverse environmental impacts contribute global warming due utilization fossil fuels especially diesel gas possible electricity supply systems towns vary diesel gas generator towards hybrid system composed generator wind turbine photovoltaic system battery energy storage order limit cost system propose economically feasible solution various combinations supply systems considered systems analyzed paper help homer software determine optimal architecture control strategy supply system study used real demand data town well prices different electrical components australian market scenario yields minimum cost energy defined suggested also decision making based technique proposed help local electricity utility finding suitable solution case budget limits investment annual operation maintenance another aim analysis investigate illustrate impact small annual load growth size selected components selected power system well total net present cost cost electricity sensitivity analysis also performed analyze impact uncertainties parameters outcome study obtain optimized cost selected system elsevier ltd rights reserved
ectomycorrhizal fungi reported increase root hydraulic conductivity altering apoplastic plasma membrane intrinsic protein pip mediated cell cell water transport pathways associated roots little effect root water transport depending interacting species imposed stresses study investigated water transport properties pip transcription roots aspen populus tremuloides seedlings colonized wild type strain laccaria bicolor strains overexpressing major fungal water transporting aquaporin inoculation aspen seedlings bicolor resulted colonization rate root tips developed dense mantle hartig net restricted modified root epidermis transcript abundance aspen aquaporins pip pip pip decreased colonized root tips root colonization overexpressing strains significant impact seedling shoot water potentials gas exchange dry mass however led decrease transcript abundance pip pip significantly lower non inoculated roots results taken together previous study showed enhanced root water hydraulics bicolor colonized white spruce picea glauca suggest impact bicolor root hydraulics varies ectomycorrhiza associated tree species
background examine whether combined use cit dopamine transporter single photon emission computed tomography dat spect mibg myocardial scintigraphy mibg superior either modality alone diagnosing parkinson disease methods patients probable underwent dat spect mibg myocardial scintigraphy within short intervals enrolled specific binding ratio sbr dat spect images heart mediastinum ratio mibg images used quantitative measures classified patients groups based sbr value ratio two groups based striatal asymmetry index sai dat spect examined clinical features group also investigated characteristics swedds scans without evidence dopaminergic deficits patients finally calculated sensitivity specificity method combined method results sbr value significantly correlated early delayed ratio values motor complications hallucinations observed high frequency group lower sbr ratio hallucinations appeared group larger sal swedds observed patients sensitivity specificity diagnosing sbr dat spect ratio mibg uptake combined modalities respectively conclusions combined use dat spect mibg myocardial scintigraphy increases specificity diagnosis helpful understanding clinical features predicting complications elsevier rights reserved
objectives study anti fertility effect dna vaccine using binb target antigen male mice methods novel recombinant eukaryotic vector containing fusion gene sequence mouse binb tandem three copies fragment used construct psg binb correct expression binb protein confirmed transfected hek cells indirect immunofluorescence western blot analysis fertility immunised mice determined mating experiment sperm motility test anti binb antibody titres sera examined elisa assays binding activity fragment fusion protein verified receptor expressing raji cells flow cytometric analysis results immunisation psg binb recombinant dna vaccine significantly decreased sperm motility compromised fertility male mice elisa results showed titres anti binb igg sera immunised mice increased markedly immunisation process anti fertility effect psg binb significantly better psg binb dna vaccine generated higher titres anti binb antibody conclusions results show recombinant dna vaccine targeting binb markedly reduce fertility male mice providing alternative approach birth control
effects land use land use changes river nutrient concentrations well understood especially watersheds developing countries mixed land use rice paddy fields developing urban surfaces present three year study paddy agricultural urban area gradient watershed southeast china annual anthropogenic nitrogen input agricultural region urban region high yet results showed monthly nutrient concentrations river low rainy seasons nutrient concentrations decreased continuously river water passed traditional agriculture region tar paddy rice wheat rotation increased substantially city region traditional agricultural reference region exported nutrient loads high flows intensified agricultural region iar aquaculture poultry farming exported nutrient loads moderate flows reference area exported nutrient loads low moderate flows developed statistical model link variations nutrient concentrations proportion land use types rainfall statistical results showed impervious surfaces interpret proxy urban activities including sewage disposal important drivers nutrient concentrations whereas water surfaces accounted substantial proportion nutrient sinks therefore efficiently reduce water pollution sewage urban areas must addressed priority although wet land restoration could also achieve substantial pollutant removal published elsevier
besides application photovoltaics semiconductor solar energy materials directly employed photocatalysts hydrogen fuel production using sunlight water feedstock paper facile hydrothermal route synthesized cuo zno junction nanocomposite absence presence carbon nanotube cnt applied water photosplitting setup evolve hydrogen gas investigation revealed presence cnt photocatalyst performance increases significantly becomes approximately twice superior activity witnessed ternary nanocomposite cuo zno cnt explained terms ability cnt enlarge photocatalyst surface area enhance absorption photons prohibit recombination photogenerated pairs finally quantum yield energy efficiency analyses performed binary ternary nanocomposite materials well semiconductor components results discussed detail physicochemical viewpoint
paper addresses optical based displacement measurement system applied structural dynamic observation april long span suspension bridge lisbon portugal namely main span central section lack nearby absolute reference points structure dynamic behaviour allow applying conventional solutions metallic suspension bridge recently developed non contact measurement solutions global navigation satellite systems microwave interferometric systems recommended since measurement accuracy affected multi path effect resulting reflections electromagnetic waves bridge structural components optical system comprised high focal length digital camera rigidly connected lower surface stiffness beam orientated towards tower foundation set four active targets installed based pinhole camera model camera intrinsic parameters targets world coordinates previously quantified targets image coordinates allowed determining camera projection centre world coordinates adopted measurement configuration considered representative central section spatial position making possible displacement measurement paper describes experimental procedures results obtained camera intrinsic parameterization also field calibration test optical system displacement measurements related train passage mentioned suspension bridge also shown analysed concluded described optical system suitable vertical transversal displacement bridge observation within determined measurement uncertainty
agriculture largest employing sector involves manpower pakistan total population participates gdp pakistan side country facing shortage water population lives rural hilly areas implementing schemes water hilly areas feasible high expenditures less progress moreover supplying water hilly areas time consuming unsafe expensive work therefore hilly areas rainwater harvesting appropriate feasible technique paper represents study runoff pattern investigate potential water harvesting sites potohar plateau pakistan techniques geographic information system remote sensing hec geohms hec hms used delineation water channels drainage line estimation runoff generation results revealed study area potential rainwater harvesting order accumulate store runoff generated annual rainfall
objective brief assessment cognition schizophrenia bacs cognitive assessment tool used measure broad aspects cognition frequently impaired patients schizophrenia study aims develop normative data chinese version bacs among mandarin speaking population method cross sectional study included healthy participants age range years mean age years men taiwan evaluated bacs means standard deviations subtests composite scores arranged age group gender scores calculated based norms compared scores based norms established study results raw scores bacs tests verbal memory digit sequencing token motor test verbal fluency symbol coding tower london negatively correlated participants age women superior men verbal memory inferior executive function furthermore applying norms bacs determine performance chinese bacs results bias regard verbal memory token motor test verbal fluency symbol coding tower london composite score conclusions findings demonstrate directly applying western cognitive norms mandarin speaking population cause biased interpretations results study important reference clinical settings research related cognitive assessments mandarin speaking chinese populations
present study new quaternary mgy mgy alloys synthesized employing disintegrated melt deposition dmd casting technique followed hot extrusion microstructural characterization revealed presence long period stacking ordered structure lpso mgyznal phases aligned along direction extrusion alloys refined grains extruded microstructures compared monolithic significant increase microhardness similar tensile yield strength similar ultimate tensile strength similar observed alloys despite significant increase strength materials failure strains alloys comparable monolithic ignition temperatures alloys found outperform commercially available high temperature alloys highest ignition temperature degrees achieved mgy alloy elsevier ltd rights reserved
background teriparatide recombinant human parathyroid hormone increasingly used treatment severe osteoporosis stimulates bone formation may potentially enhance fracture healing objective study investigate effects teriparatide versus bisphosphonate radiographic outcomes treatment osteoporotic vertebral compression fractures ovcf methods total patients undergoing non operative treatment recent single level ovcf reviewed retrospectively thirty eight patients treated daily subcutaneous injection micrograms teriparatide tpd group whereas patients received alendronate weekly group except medications treatment protocol applied groups radiographic assessments included union status vertebral kyphosis mid vertebral body height rates fracture site surgical intervention also compared two groups mean follow period months median range months results cox regression analysis showed tpd reduced time union adjusted relative hazard ratio union rate six months treatment tpd group group surgical intervention rate significantly higher tpd group adjusted odds ratio change local kyphosis degrees tpd group degrees group paired test change mid vertebral body height tpd group group paired test fracture site surgical interventions required tpd group however two patients group eventually underwent surgical treatment symptomatic non union vertebral collapse conclusions retrospective study suggests teriparatide may enhance fracture healing improve union rate ovcf
sensitizing young adults sleep hygiene knowledge helpful sleep attitudes may potential instill long lasting healthy sleep practices towards ends evaluation psychoeducational program sleep tailored college students undertaken following two weeks sleep log recordings participants randomly assigned sleep experimental condition sleep monitoring control condition sleep condition comprised two minute workshops aimed educate students healthy sleep practices helpful thoughts sleep ways improve sleep sleep monitoring group received sleep hygiene handout completed sleep logs study duration sleep participants endorsed fewer maladaptive beliefs attitudes sleep increased sleep hygiene knowledge reduced sleep onset latency compared sleep monitoring participants brief psychoeducational courses may cost effective way alleviate current prevent future sleep problems young adults
design lab chip microfluidic devices typically preceded long costly period prototyping stages system gradually refined iterative process involving manufacturing physical prototype making lot laboratory experiments scenario virtual prototyping framework allows emulation behavior complete system greatly welcome paper presents framework details virtual prototyping methodology able soundly handle microfluidic behavior based systemc ams extensions use extensions permit communication developed microfluidic models external digital mixed signal devices allows emulation whole lab chip system usually includes digital control mixed signal reading environment moreover systemc ams also extended cover physical domains within catrene project interactions domains possible example electromechanical optical parts part system presented extensions manage modeling micro fluidic system detailed two approaches selected model fluid analytically based poiseuille flow theory model fluid numerically following sph smoothed particle hydrodynamics approach modeling techniques encapsulated tdf timed data flow moc model computation systemc ams elsevier rights reserved
chitin polysaccharide particular abundance fungi nematodes arthropods immunogenic acts threat organisms tackle endowed chitinase enzyme even enzyme present organisms possess proteins chitin binding domain chtbd many lethal viruses like ebola hcv hepatitis virus domains manipulate carriers target organisms keeping basic rule survival self origin body component chitins chitinases protective non self origin organisms detrimental health exogenous chitins chitinases provoke human innate immunity generate deluge inflammatory cytokines injure organs leading asthma atopic dermatitis etc persistent situations lead death multiple sclerosis systemic lupus erythromatosus sle cancer etc unfortunately chitin chitinase stimulated hypersensitivity common cause occupational allergy hand chitin deacetylated derivative chitosan increasingly proving useful pharmaceutical agriculture biocontrol applications critical review discusses complex nexus chitin chitinase assesses pathogenic well utilitarian aspects elsevier rights reserved
plant diseases one major bottlenecks agricultural production bad effects economic country automatic detection disease could minimize effects features selection usual pre processing step used automatic disease detection systems important process detecting eliminating noisy irrelevant redundant data thus could lead improve detection performance paper improved moth flame approach automatically detect tomato diseases proposed moth flame fitness function depends rough sets dependency degree takes consideration number selected features proposed algorithm used power exploration moth flame high performance rough sets feature selection task find set features maximizing classification accuracy evaluated using support vector machine svm performance mforsfs algorithm evaluated using many benchmark datasets taken uci machine learning data repository compared feature selection approaches based particle swarm optimization pso genetic algorithms rough sets proposed algorithm used real life problem detecting tomato diseases powdery mildew early blight real dataset tomato disease manually built tomato disease detection approach proposed evaluated using dataset experimental results showed proposed algorithm efficient terms recall precision accuracy score long feature size reduction execution time elsevier rights reserved
fluid structure interaction fsi affects dynamic characteristics behaviors fluid structure able understand solve fsi problems important engineering science medicine everyday life generally fsi problems simulated either monolithic partitioned methods still many challenges development better numerical methods fsi problems terms accuracy problem scale stability robustness efficiency focused partitioned methods allow use existing flow structural analysis solvers without elaborate modification paper describes development parallel partitioned coupling analysis system large scale fsi problems study employed existing flow structural analysis solvers frontflow blue ffb adventure solid respectively general purpose codes used solve large scale analysis models ranging millions billions degrees freedom dofs addition developed parallel coupling tool called adventure coupler efficiently handle exchange interface variables various parallel computing environments achieve robust fast convergence fixed point iteration employed broyden method quasi newton method update interface variables verified accuracy fundamental performance developed fsi analysis system using solve fsi benchmark problem vortex induced oscillation flexible plate wake square column results agreed quantitatively well researchers results finally successfully applied system analysis three dimensional flapping motion elastic rectangular plate objective furthering research development micro air vehicles mavs flapping wings elsevier ltd rights reserved
pillar industry chinese national economy construction industry made great strides building construction issue become increasingly prominent number deaths mining industry construction industry exceeded coal mining enterprises ranking caused heavy lose also serious impact development industry paper analyzes causes construction enterprises producing high incidence accidents deeper reason sense leadership levels business production management personnel levels lack knowledge awareness behind meanwhile construction site currently engaged building management staff mostly related management civil engineering engineering graduate students students school learn basics received knowledge building health education therefore situation paper training universities actively explore construction management personnel particularly important
exploiting unique social economic differences east west germany authors investigated macro level opportunities interact couple level decision making explain gender differences determinants economic outcomes household migration incorporating regional socioeconomic conditions household bargaining theory hypotheses region derived hypotheses tested using cross classified multilevel regressions german socio economic panel combined regional economic indicators first gender specific determinants couples west west within west germany east west migration analyzed second subsequent economic consequences investigated comparing couples singles results confirm gender differences macro conditions impose decision logics seemingly contradict initial power relation within couples despite traditional gender arrangements west germany well educated partnered women earn significant absolute relative income gains migration egalitarian east german counterparts suffer significant losses compared single women east german men
psoriasis common disease affecting population produces significant impairment quality life immense burden sufferers families psoriasis associated significant cardiovascular comorbidity metabolic syndrome angiogenesis relatively researched component psoriasis key factor pathogenesis psoriasis also contributes development atherosclerosis vascular endothelial growth factor vegf well established mediator pathological angiogenesis upregulated psoriasis possible patients psoriasis cutaneous angiogenesis may marker systemic vascular pathology novel therapeutic target viewpoint study role vegf mediated angiogenesis cause cardiovascular events patients psoriasis explored
objective compare clinical outcome patients presenting symptoms uncomplicated cystitis seen doctor patients given treatment following diagnostic algorithm design randomized controlled trial setting hours service oslo norway intervention women typical symptoms uncomplicated cystitis included trial time period september november randomized two groups one group received standard treatment according diagnostic algorithm group received treatment regular consultation doctor subjects women aged years mean age groups years main outcome measures number days symptomatic resolution results significant differences found groups basic patient demographics severity symptoms percentage urine samples single culture growth median three days symptomatic resolution found groups day four algorithm group regular consultation group free symptoms number patients contacted doctor follow period received alternative antibiotic treatment insignificantly higher regular consultation treatment according diagnostic algorithm cases severe pyelonephritis hospital admissions follow period conclusion using diagnostic algorithm safe efficient method treating women symptoms uncomplicated cystitis hours service simplification treatment strategy lead rational use consultation time stricter adherence national antibiotic guidelines common disorder
work reports numerical investigation transient operation solar reactor performing high temperature step zno thermochemical cycle two step redox cycle comprises endothermal dissociation zno using concentrated solar energy subsequent oxidation produce performance solar reactor investigated using dynamic numerical model consisting two coupled submodels first monte carlo ray tracing model applied compute spatial distribution maps incident solar flux absorbed reactor surfaces subjected concentrated solar irradiation delivered promes cnrs megawatt solar furnace mwsf second heat transfer thermochemical model uses computed maps absorbed solar flux radiation boundary condition simulate coupled processes chemical reaction heat transfer radiation convection conduction experimental validation solar reactor model accomplished comparing solar radiative power input temperatures zno dissociation rates measured data acquired solar reactor mwsf experimentally obtained solar chemical energy conversion efficiencies reported various energy flows quantified model shows prominent influence reaction kinetics attainable energy conversion efficiencies revealing potential achieving eta solar chemical provided mass transport limitations zno reaction interface overcome
experiments model foraging behavior formation conditions free choice maze revealed learning failure background reduced motor activity offspring rats exposed tobacco smoke gestation days afobazole administered pregnant rats orally doses daily whole gestation entering rat pup body breast milk mothers receiving day life normalized learning capacity formation short term long term memory animals receiving afobazole differ control hence afobazole corrects cognitive disorders rats exposed tobacco smoke prenatal development
study explored potential computer vision system cvs hyperspectral imaging hsi technique covering spectral range identifying freezer burnt salmon fillets frozen storage local binary pattern lbp descriptor applied rgb image classification reflectance spectra obtained various positions surface pretreated using standard normal variate snv transformation treebagger classifier used build classification models recognition authentication freezer burnt flesh results suggested hyperspectral discrimination performed much better cvs correct classification rate ccr validation ccr cross validation effective wavelengths selected based upon feature importance treebagger model corresponding optimized model yielded ccr validation cross validation overall outcome suggested capability hsi rapid categorization damaged regions frozen salmon elsevier ltd iir rights reserved
changes electric utility necessitate new needs opportunities monitoring controlling electric power consumption generation technical solutions exploiting opportunities answering needs would ideally preserve best practices like reliability privacy efficiency flexibility nonintrusive load monitor nilm serve ideal platform constructing energy box capable sophisticated monitoring control paper introduces data processing analysis framework nilm manager nilm manager creates business model handling power data minimizing network bandwidth placing intelligence feature expansion easily transmitted energy apps
implementation cryptography algorithms constantly observing threat multiple techniques breaking secure system current trend breaking secure system cryptography power analysis technique order break secure key energy consumed digital circuit computation measured technique commonly known differential power analysis explored hackers break secure systems circumvent type attacks necessary explore different designs dissipate less energy ideally reversible circuits dissipate zero energy present new reversible architecture greatest common divisor gcd computation using modified binary gcd algorithm present generalized design methodology reversible gcd computation unit compare proposed gcd computation design existing design proposed reversible gcd architecture takes less number iterations compared existing gcd architecture literature proposed design outperforms existing gcd design terms quantum cost gate count ancilla inputs copyright john wiley sons ltd
improving safety transportation systems attracts lots attention researchers introduced methods detect analyze vehicle pedestrian road accomplish goal however bicycle also significant factor safety road paper bicycle detector side view image proposed based observation bicycle consists two wheels form ellipse shapes frame form two triangles proposed triangle detection algorithm bicycle model geometric constraints relationship triangles ellipses computation fast according sample implementation evaluation reduced data amount besides training process unnecessary single image required algorithm experimental results also given paper show practicability performance proposed bicycle model bicycle detection algorithm
background previous studies reported human immunodeficiency virus hiv infection antiretroviral therapy art lead osteoporosis hiv infected individuals however effects alveolar bone well established objective study measure alveolar bone mineral density bmd hiv infected patients without antiretroviral therapy art comparison hiv free individuals determine factors associated bmd alveolar bone methods cross sectional study performed non hiv infected individuals hiv infected individuals without art medical status clinical data recorded periapical radiographs maxillary mandibular right premolars analysed changes alveolar bmd based hiv art status factors associated changes alveolar bmd explored using parametric multivariate analysis covariance mancova results one hundred one hiv infected individuals receiving art age range years median age years receiving art age range years median age years hiv negative individuals age range years median age years enrolled neither hiv status use art significantly associated changes alveolar bmd conclusion although osteoporosis reported hiv infected individuals treated art alveolar bmd appear changed result infection use art
social support family friends significant others known buffer impact adverse life events children well functioning however little known pathways explaining association investigated whether maltreatment related cognitions mediate association social support posttraumatic stress symptoms ptss furthermore age introduced moderator assessed history maltreatment maltreated children adolescents age years using semi structured interview participants perceived current social support maltreatment related negative cognitions related subjectively worst experience maltreatment ptss past month assessed using self report questionnaires set mediation analyses demonstrated negative maltreatment related appraisals mediated relation perceived social support ptss hypothesized negative associations social support ptss dysfunctional cognitions differ children years adolescents years thus protective function social support maltreatment explained fewer negative beliefs maltreated youth world results provide support models social cognitive processing emphasize importance cognitive coping regard episodes maltreatment shaped within social interactions non abusive caregivers friends significant others elsevier ltd rights reserved
heavy agricultural equipments cause high compaction top layer soil agriculture present method soil compaction measurement ergonomically good practice hand held penetrometers either static dynamic india compaction data taken hand operated penetrometers generally certain limitations chance error manually operated penetrometers dial gauge digital display type penetrometers however developed countries using automatic multi probe type sensor collecting data soil penetration resistance due limitations hand held penetrometers tractor operated sensor based soil compaction measurement device developed increases volume data particular area reduce human factor error upgrade quality measurement used indian scientific community agricultural soil compaction scientists correlate crop parameters grown data used agricultural machine design different crop parameters hence recommendations particular machinery particular area crop generated soil compactness soil moisture content maps give colour coded maps area particular region specific crop area needs attention priority basis
aims examine factors related excess mortality cohort adults congenital heart disease chd methods results conducted survival analysis using prospective data adults chd males median age entry years iqr median follow time years iqr survival status patient verified cross checking spanish national death index total follow person years patients died annual death rate standardized mortality ratio smr confidence interval median age death estimated left truncated kaplan meier method years survival reduced compared general population whatever level complexity repair status underlying chd independent risk factors excess mortality including cyanosis univentricular physiology genetic disorders ventricular dysfunction residual haemodynamic lesions acquired late complications among others identified left truncated cox regression model smr median age death years patients least one risk factor contrast smr median age death years patients risk factors conclusions clinical parameters anatomical features haemodynamic sequelae acquired complications independent predictors excess mortality adults chd survival individuals risk factors differ reference population
background autologous platelet rich plasma prp widely used treatment sports injuries associated improved healing regeneration soft tissues elite athletes athletes commonly receiving nonsteroidal anti inflammatory drugs nsaids yet effect drugs platelet function prp formulations taken consideration hypothesis function platelets prp produced influence nsaids inhibited may lessen possible healing effect site injury study design controlled laboratory study methods prp collected patients receiving nsaids elective orthopaedic surgery platelet function evaluated using light transmission aggregometry lta results compared obtained healthy volunteers without history nsaid intake previous weeks two different systems blood collection prp production arthrex acp double syringe system standard sodium citrate blood collection tubes used compared regarding quality prp produced results groups baseline platelet counts whole blood platelet counts prp formulations found normal range collection systems prp produced comparable results without significant differences groups platelet function testing lta revealed significantly impaired platelet aggregation prp preparations obtained patients taking nsaids irrespective type nsaid subjects control group showed normal platelet aggregation patterns tested lta conclusion autologous prp produced subjects nsaid medication shows significantly impaired platelet function may result lower quality regarding content bioactive compounds
aimchildren nephrotic syndrome prolonged disease course relapses requiring frequent visits prolonged steroid therapy long term concerns factors affect child families many domains functioning objective study assess multidimensional impact families children nephrotic syndrome using pedsql family impact module fim methodsthis cross sectional study conducted paediatric nephrology clinic tertiary care hospital fifty cases steroid sensitive nephrotic syndrome age group years included equal age sex matched healthy children taken controls baseline demographic factors including age gender education status modified kuppuswamy socio economic status collected clinical variables cases recorded fim parent reported instrument measures impact paediatric chronic health conditions care giver hrqol family function mean fim scores compared among cases controls different predictive factors affecting family impact analysed resultsthe total score showed significantly lower scores cases mean score compared controls mean among individual groups lowest scores found two domains namely worry emotional function mean scores respectively although domains also significantly affected conclusion score evaluated cases parenting children may significantly affect domains family functioning
one teenagers key developmental tasks engage new meaningful relationships peers adults outside family context attachment derived expectations self others terms internal attachment working models potential shape social reorientation processes critically thereby influence adolescents social emotional development social integration neural underpinnings developmental task remain largely unknown sought investigate functional magnetic resonance imaging asked adolescents ages years evaluate positive negative adjectives regarding either close adapted version well established self trait evaluation task measures attachment obtained scores reflecting participants positive versus negative attachment derived self models means relationship questionnaire controlled possible confounding factors also obtaining scores reflecting internalizing externalizing problems schizotypy borderline symptomatology results revealed participants negative attachment derived self model showed increased brain activity positive negative adjective evaluation regarding self decreased brain activity negative adjective evaluation regarding close bilateral amygdala parahippocampus bilateral anterior temporal pole anterior superior temporal gyrus left dorsolateral prefrontal cortex findings suggest low positivity self concept characteristic attachment anxiety dimension may influence neural information processing opposite directions comes self versus close representations discuss results framework attachment theory regarding implications especially adolescent social emotional development social integration
osteochondral tissue complex graded structure biological physiological mechanical properties vary significantly full thickness spanning subchondral bone region beneath joint surface hyaline cartilage region joint surface presents significant challenge tissue engineered structures addressing osteochondral defects fused deposition modeling fdm bioprinters present unique solution problem objective study use fdm based bioprinting nanocrystalline hydroxyapatite improved bone marrow human mesenchymal stem cell hmsc adhesion growth osteochondral differentiation fdm printing parameters tuned computer aided design computer numerical control software manipulate scaffold geometries ways beneficial mechanical performance without hindering cellular behavior additionally ability fine tune printed scaffolds increases investment casting procedure facilitates inclusion nanoparticles biochemical factors elicit desired hmsc differentiation study fdm used print investment casting molds innovatively designed varied pore distribution full thickness scaffold mechanical biological impacts varied pore distributions compared evaluated determine benefits physical manipulation results indicate mechanical properties cell performance improve graded pore structures compared homogeneously distributed porous non porous structures differentiation results indicated successful osteogenic chondrogenic manipulation engineered scaffolds
structure cobalt oxide coox nanoparticles dispersed rutile tio tio characterized ray diffraction vis nir diffuse reflectance spectroscopy high resolution transmission electron microscopy ray absorption fine structure spectroscopy ray photoelectron spectroscopy coox nanoparticles loaded onto tio impregnation method aqueous solution containing center dot followed heating air modification tio followed heating resulted highest photocatalytic activity good reproducibility structural analyses revealed activity photocatalyst depended strongly generation coo nanoclusters optimal distribution nanoclusters thought interact tio surface resulting visible light absorption active sites water oxidation
paper presents novel system configuration voltage source converter vsc based high voltage direct current hvdc transmission connected large scale offshore wind power plant wpp proposed scheme reconfigured onshore end achieve shunt series compensation named unified vsc hvdc vsc hvdc mathematical model proposed configuration derived determine rating employed series shunt converters achieve flexible control strategy balanced unbalanced fault conditions proposed transient management scheme employs positive negative sequence controllers series compensation negative sequence voltage components determined way minimize power oscillations caused asymmetrical faults hence reduce link voltage overshoots test system comprised detailed representation proposed configuration simulated evaluated using pscad emtdc comprehensive study validates capability proposed configuration transient management scheme achieving smooth power transfer superior transient performance electrical grid also minimizes possibilities electrical network propagations response symmetrical asymmetrical grid faults
metformin frequently administered drug treatment type diabetes investigated potential treatment various types cancer however cellular basis putative anti cancer action remains controversial current study examined effect metformin endoplasmic reticulum stress autophagy glucose starved micro vascular endothelial cells mec rationale experimental protocol growing tumor mecs subjected hypoxia nutrient glucose starvation results reduced supply relatively high consumption glucose mouse mecs mmecs glucose starved absence presence metformin status stress autophagic cell survival apoptotic markers assessed activation stress autophagy observed glucose starved mecs evidenced significant increase levels stress autophagic markers accumulation lcb stained punctae mec confirmed autophagic activation treatment metformin independent ampk significantly reversed glucose starvation induced stress autophagy mec decrease cell viability however persistent stress metformin associated inhibition autophagy decreased cell viability caused cell cycle arrest increased number cells sub phase cell cycle treatment metformin reduced phosphorylation akt mtor inhibited downstream targets mtor findings support argument treatment metformin used combination glycolytic inhibitors inhibit pro survival autophagy promote cell death potentially prove basis effective anti cancer strategy elsevier inc rights reserved
posaconazole recommended prophylactic agent patients high risk invasive fungal infection since adequate drug levels seem reached target sites despite relatively low levels detected blood objective study obtain pharmacokinetic information associated blood tissue distribution posaconazole animal model invasive pulmonary aspergillosis parameters lung samples systematically higher serum multiple dose administration posaconazole significant accumulation drug evident lung tissue behavior posaconazole particular experimental model similar observed humans thus believe model could valid tool evaluate posaconazole exposure response relationship elsevier inc rights reserved
paper presents novel approach demand side management dsm using individualized price policy end user receives separate electricity pricing scheme designed incentivize demand management order optimally manage flexible demands pricing schemes objective reducing peaks overall system demand way average electricity price individual user receives non discriminatory shown paper approach number advantages benefits compared traditional dsm approaches demand aware price policy approach outlined paper exploits knowledge demand awareness obtained advanced metering infrastructure presented analysis includes detailed case study existing european distribution network dsm trial data available residential end users
backgrounds coeliac disease prevalence liver test abnormalities ltas higher patients severe mucosal inflammation crohn disease prognosis related severity mucosal inflammation aim aim study investigate whether presence lta predicts occurrence complicated disease behaviour newly diagnosed crohn disease methods retrospective cohort study performed patients newly diagnosed crohn disease complicated disease defined occurrence stricturing perforating disease ltas defined value alkaline phosphatase gamma glutamyl transpeptidase ggt aspartate aminotransferase ast alanine aminotransferase alt upper limit normal results three hundred eighty three patients included lta ltas mostly mild less two times upper limit normal year follow patients group lta developed complicated disease behaviour compared patients without lta presence lta identified risk factor complicated disease behaviour confidence interval conclusions newly diagnosed crohn disease presence lta independent risk factor development complicated disease behaviour
introduction fatigue common disabling symptom may seen early parkinson disease understanding phenomenology etiology fatigue limited objective study determine whether fatigue related cognition early patients methods study part norwegian parkwest project population based cohort study comprising novo drug naive patients diagnosed according gelb criteria fatigue assessed fatigue severity scale fss cognition assessed battery tests evaluating functions domains verbal memory processing speed executive function visuospatial abilities results cohort moderate severe fatigue fss univariate correlation analyses high fatigue score correlated disease severity presence sleep problems depressive symptoms apathy reduced processing speed reduced visuospatial abilities multiple regression analysis disease severity measured updrs part sleep problems depressive symptoms reduced visuospatial abilities contributed model conclusion fatigue associated visuospatial function early patients studies needed determine pathophysiologic relevance association elsevier ltd rights reserved
early experience social context interact alter phenotype complex social behaviors early experiences also result alterations cortical organization connections given ability neuropeptide oxytocin modulate social reproductive behavior likely involved cortical processes however little known distribution receptors otr within neocortex using autoradiographic neuroanatomical techniques characterized cortical distribution receptors otr prairie voles socially monogamous rodent species found otr density low primary sensory areas including primary somatosensory auditory regions quite high association regions including temporal parietal association areas prelimbic regions primary motor area well temporal parietal association areas observed differences otr density across cortical layers specifically cortical layers exhibited greater otr density layer results point role integrating sensory motor prairie vole brain providing complementary mechanism modulation social interactions given ability early social experience developmental manipulations affect brain behavior results suggest novel mechanism may influence cortical organization ibro published elsevier ltd rights reserved
somatic mutations codons jak exon highly specific confirm diagnosis polycythemia vera aim study develop pyrosequencing method detection quantification jak exon allele burden nucleotide sequencing jak exon fragment carried use pyromark verify presence mutations dna sequences extracted clinical samples cloned obtained clones sequenced use reagents equipment applied biosystems usa sample containing mutation analyzed confirming presence mutations clones sanger sequencing pyromark quantification jak exon allele burden among jak negative patients high clinical hematological probability diagnosis del mutation jak exon detected years old male patient detection quantification jak exon allele burden virtue using pyrosequencing method patient carried three times august june results show jak del allele burden increase twice months following patient data suggest increase number transformed clonal cells proposed method allows detecting carrying quantitative determination mutant jak exon allele burden monitoring efficacy therapy
dynamic programming demanding algorithm design technique article introduce extension recursion visualization system srec intended support dynamic programming contributions chapter threefold firstly present srec support several phases systematic development dynamic programming algorithms generation recursion trees checking recursion redundancy recursion tree generation dependency graph associated recursion tree matching graph table facilities require high degree interactivity effective article illustrates facilities construction dynamic programming algorithm knapsack problem secondly address several pragmatic issues usage educational scenarios experience dynamic programming algorithms limitations thirdly article reports results evaluation system usability results positive providing evidence adequateness extensions furthermore allowed identifying minor opportunities improvements
research suggests benefiting someone voluntary intentional costly effort encourages reciprocal prosocial behavior well promoting upstream reciprocity increases reciprocal actions recipient benefit unrelated third party current study examines role identifiability benefactor determining extent people engage direct upstream reciprocity results three studies reveal identified benefactor tends engender greater direct reciprocal reactions unidentified one strong reaction toward identified benefactor hold extent upstream reciprocity considered regardless identification third party hand benefactor unidentified levels direct upstream reciprocity remain similar moderated mediation analysis suggests ethical commitment associated universal norm reciprocity explains decrease prosociality reactions toward benefactor toward third party identified condition copyright john wiley sons ltd
canine chronic ulcerative stomatitis also known chronic ulcerative paradental stomatitis painful condition oral cavity purpose study determine commonalities clinical radiographic features among patients whether histopathologic evaluation might inform pathogenesis whether condition appears similar human oral mucosal diseases prospectively collected clinical radiographic histopathologic data dogs diagnosed disease clinical data based clinical disease activity index oral periodontal examination parameters full mouth dental radiographs histopathological immunohistochemical data based oral mucosal samples obtained erosive ulcerated areas findings revealed canine chronic stomatitis clinically characterized painful oral mucosal ulcers varying size pattern appearance distribution often associated teeth early periodontitis histologic examination revealed subepithelial lichenoid band interface mucositis cells cells forkhead box protein foxp interleukin expressing cells present cells might play role underlying immune response immune mediated pathogenesis suspected clinical histopathologic features chronic inflammatory mucosal disease dogs resemble oral lichen planus humans
approach integrated research action model interactions psychosis parent parenting family relations child development risk resilience factors research objectives identifying resilience factors research interaction risk resilience mechanisms predicting development psychopathology children psychotic parents dynamic evaluation resilience longitudinal study conducted period group children schizophrenic parent children parent bipolar disorder applied scales cbcl vth axis icd panss risc connor davidson resilience scale panss psychotic parents correlated scores specific items obtained children risc manova pearson test correlated dependent variables predictive influence factors high panss scores specific items correlated negatively resilience scores children psychotic parents maximum frequency positive codifications vth axis found rejection behavior one parent family disharmony distorted family communication significantly correlated low scores child resilience personal competency negative effects tolerance safe interpersonal relations high performance social family support social connectedness proved relevant variables resilience modified improved targeted interventions understanding resilience process concurrent factors needed
background whether hypothyroidism independent risk factor cardiovascular events still disputed aimed assess association hypothyroidism risks cardiovascular events mortality methods searched pubmed embase inception february cohort studies included restriction hypothyroid states priori main outcomes ischemic heart disease ihd cardiac mortality cardiovascular mortality cause mortality results fifty five cohort studies involving participants identified patients hypothyroidism compared euthyroidism experienced higher risks ihd relative risk confidence interval myocardial infarction cardiac mortality cause mortality subclinical hypothyroidism sch especially thyrotropin level miu also associated higher risks ihd cardiac mortality moreover cardiac patients hypothyroidism compared euthyroidism experienced higher risks cardiac mortality cause mortality conclusions hypothyroidism risk factor ihd cardiac mortality hypothyroidism associated higher risks cardiac mortality cause mortality compared euthyroidism general public patients cardiac disease
slow paced persistent attack slow worm bot bewilder detection system slowing attack detecting attacks based traditional anomaly detection techniques may yield high false alarm rates paper frame problem detecting slow paced persistent attacks time series obtained network trace focus time series spectrum analysis identify peculiar spectral patterns may represent occurrence persistent activity time domain propose method adaptively detect slow paced persistent attacks time series evaluate proposed method conducting experiments using synthesized traffic real world traffic results show proposed method capable detecting slow paced persistent attacks even noisy environment mixed legitimate traffic
ethnopharmacological relevance kidney deficiency main pathogenesis osteoporosis based theory kidney governing bones traditional chinese medicine tcm combined herba epimedii fructus ligustri lucidi based traditional chinese formula zhi pills frequently used tcm formulas prescribed kidney tonifying bone strengthening however unclear whether combination two herbs may protective influence glucocorticoid induced osteoporosis giop objective study evaluate therapeutic effects underlying molecular mechanism decoction active fractions combined herbs giop rats materials methods male sprague dawley rats divided seven groups including normal control giop model active fractions low laf active fractions high haf decoction low decoction high calcium vitamin cad treated group giop model established intramuscular injection dexamethasone twice week weeks different kinds indicators measured including bone mineral density bmd bone biomechanical properties serum bone alkaline phosphatase alp serum bone carboxyglutamic acid containing protein bgp serum bone morphogenetic protein bmp serum tartrate resistant acid phosphatase tracp serum carboxy terminal cross linked telopeptide typelcollagen ictp bone mineral content bmc bone structured histomorphometry protein mrna expression tgf beta smad smad smad smad detected western blotting quantitative real time polymerase chain reaction qrt pcr respectively results administration combined herba epimedii fructus ligustri lucidi decoction combined active fractions could significantly prevent induced bone loss increasing contents serum alp bgp bmp markers bone formation reducing serum tracp ictp contents inhibit bone resorption enhancing bmc could also attenuate biomechanical properties bmd reduction deterioration trabecular architecture rats mrna protein expressions tgf smad smad smad regulated mrna protein expression smad regulated following combined herba epimedii fructus ligustri lucidi treatment conclusion combination herba epimedii fructus ligustri lucidi exhibited protective effects promoting bone formation precluding bone resorption underlying mechanism may attributed regulations tgf beta smads pathway substance bases combined herbs anti osteoporosis total flavonoids herba epimedii total iridoids flavonoids fructus ligustri lucidi
paper theoretical analysis simulation simply supported circular cylindrical shell linearly changed temperature filed proposed influence material properties internal thermal change equivalent stiffness structure considered difference influence material properties internal thermal discussed dynamic modeling variable stiffness cylindrical shells action temperature field built considering influence young modulus basic frequency different modes based theory piezoelectric material used actuator eliminate effects thermal environment direction research enhance performance structures base general materials using smart material effective control methods future
purposeadverse drug reactions adrs including medication allergies well described among large national cohorts study described common documented medication allergies reactions among national cohort veterans affairs inpatients methodswe evaluated inpatient admissions medical center january december admission linked allergy history preceding upon admission individual drugs aggregated drug class category including penicillins sulfonamides angiotensin converting enzyme ace inhibitors opiates hmg coa reductase inhibitors statins non steroidal anti inflammatory inhibitors nsaid results reported aggregate time resultsapproximately million inpatient admissions occurred found commonly reported allergy drug classes penicillins opiates ace inhibitors sulfonamides nsaids statins several allergy histories increased time including opiates ace inhibitors statins nsaids rash commonly documented reaction reports penicillins sulfonamides nsaids common reaction opiates nausea vomiting cough coughing ace inhibitors muscle pain myalgia statins conclusionswe report penicillins opiates commonly documented drug allergies among inpatients drug classes ace inhibitors statins nsaids becoming increasingly common clinicians also commonly document non allergic adrs allergy section cough myalgia copyright john wiley sons ltd
introduction late onset bipolar disorder common addition bipolar disorder dominancy sexual behaviors rare hence traumatic vigorous sexual behavior masturbation self mutilation odd rare occurrences case presentation elderly woman manic phase bipolar disorder without previous history psychiatric disorders concomitant problematic sexual stimulation context hyper sexuality traumatized genitals underwent surgery repair following admission psychopharmacologic therapy recovered conclusions presentation bipolar disorder elderly seen sexual behaviors self mutilation lead need reparative surgery case trauma external genitalia psychiatric problems considered
development emotion regulation strategies central developmental task childhood especially children confronted problems stressors strategies effectively support downregulation negative emotions sadness important children health development particular functional emotion regulation strategies active problem solving positive reframing connected health well whereas dysfunctional emotion regulation strategies rumination withdrawal instead connected emotional behavioral problems despite fact many factors assumed involved development strategies question conditions contribute acquisition repertoire functional strategies sufficiently investigated date family context particular seems play pivotal role development tripartite model familial influence morris silk steinberg myers robinson posit children learn three possible ways observation modeling emotion related parenting practices emotional climate although separate pathways tripartite model partially investigated studies take variables one pathway account rare moreover moderating mediating relationships often neglected study preschool children ages years female one parents female interplay selected pathways suggested model supported particular relation parents children pathway direct indirect role emotional climate family pathway defined positive negative parenting well marital relationship investigated moreover study focuses consequences children problem behavior path analyses show specific effects variable family climate summary results indicate positive relation parents children dys functional strategies relation parents children functional strategies however undermined presence negative emotional climate family negative parenting punitive parenting behavior turn connected higher score children problem behavior positive emotional climate family warm consistent parenting positive marital quality however neither directly contributes children adjustment enhance learning strategies family implications research practical relevance results discussed
inversion laplace beltrami operator computation hodge decomposition tangential vector field smooth surfaces arise computational tasks many areas science computer graphics machine learning computational physics present high order accurate pseudo spectral approach applicable closed surfaces genus one three dimensional space view toward applications plasma physics fluid dynamics wiley periodicals inc numer methods partial differential
two studies examined whether social identity processes group identification social identity threat amplify degree people attend social category information early perception assessed event related brain potentials erps participants presented faces muslims non muslims evaluative priming task erps measured implicit evaluative bias assessed study revealed non muslims showed stronger differentiation ingroup outgroup faces early later processing stages implicit evaluations identified strongly ethnic group moreover identification effects implicit bias mediated intergroup differentiation study social identity threat control manipulated among muslims results revealed high social identity threat resulted stronger differentiation muslims non muslims early late implicit evaluations processing stages effects predicting implicit bias combined studies reveal seemingly bottom early social categorization processes affected individual contextual variables affect meaning social identity implications results social identity perspective well social cognitive theories person perception discussed
hydroxyurea widely used first line cytoreductive therapy patients high risk philadelphia negative myeloproliferative neoplasms neg mpn small proportion patients refractory disease experience adverse effects studies demonstrated busulfan active first line agent data role second line later therapy minimal evaluate efficacy safety context undertook multicenter audit neg mpn patients received therapy intolerance failure patients identified achieved either complete partial hematological response following least one cycle generally well tolerated cycles complicated adverse effects predominantly cytopenia cycles ceased due treatment complications effective well tolerated agent patients neg mpn setting intolerance unresponsiveness
vertical gate around vgaa structure shown one promising devices scaling beyond reduced area large driving current good gate control moreover emerging devices heterojunction tunneling fets amenable vertical fabrication however past studies vertical channel devices focused regular memory architectures simple standard cells like inverters since naive migration regular finfet layouts vertical fets yields little benefits identify several vertical efficient layout structures propose novel layout generation heuristics vertical channel devices also compare vgaa symmetric asymmetric source drain architectures different contact placement strategies layout efficiencies several vgaa structures vertical double gate lateral gate around lgaa finfet presented experiments routing congestion estimation cell level chip level placement routing also presented observe even though vertical channel standard cells diffusion gaps lateral cells still benefit vertical architectures area vertically aligned top contacts asymmetric architectures area larger symmetric architectures extra diffusion gaps needed experiments indicate symmetric asymmetric architectures vertical channel devices likely density advantage lateral channel devices
prenatal development teeth camel foetuses different length studied radiographically radiographs first recorded incidence teeth maxillary mandibular foetuses length followed mandibular centrals length full term foetus total six teeth mandibular maxillary jaws recognised age maxillary mandibular yet detected radiographs erupted later mature animal
correlation socioeconomic disadvantage child maltreatment long observed drivers association poorly understood sought estimate effects economic factors risk child maltreatment adjusting known influences using australian temperament project population based birth cohort individuals parents used logistic regression estimate associations childhood economic factors parental education occupation unemployment type housing retrospective perception poverty retrospective reports perceived child maltreatment physical abuse sexual abuse emotional abuse neglect witnessing domestic violence controlling demographic factors parental mental health substance use child health used estimates approximate proportions child maltreatment population attributable fractions theoretically preventable addressing childhood economic disadvantage economic factors associated types child maltreatment part associations diminished partially controlling noneconomic con founders supporting hypotheses causal relationships jointly economic factors significant predictors physical abuse sexual abuse witnessing domestic violence emotional abuse neglect retrospective perceptions childhood poverty particular strongly associated forms child maltreatment sexual abuse accounting economic factors estimated child maltreatment jointly attributable economic factors findings suggest strategies reduce economic disadvantage likely hold significant potential reduce prevalence child maltreatment elsevier ltd rights reserved
oral microbiota survives daily physical chemical perturbations intake food personal hygiene measures resulting long term stable microbiome biological properties confer stability microbiome important prevention dysbiosis microbial shift toward disease periodontitis caries although processes underlie oral diseases studied extensively processes involved maintaining normal healthy microbiome poorly understood review present hypothesis healthy oral microbiome acquired maintained introduce view prenatal development tolerance normal oral microbiome propose development fetal tolerance toward microbiome mother pregnancy major factor successful acquisition normal microbiome describe processes influence establishment microbiome followed perspective process sustaining healthy oral microbiome divide microbiome maintenance factors host derived microbe derived focusing host finally highlight need directions future research
pseudorandom binary sequences play crucial role cryptography classical approach pseudorandomness binary sequences based computational complexity approach certain weak points thus last two decades new constructive quantitative approach developed since multidimensional analogs binary sequences called binary lattices also important applications thus natural idea extend new approach multidimensional case extension started paper published since papers written subject goal present survey papers elsevier rights reserved
objectives describe contraceptive use among female family planning providers compare contraceptive choices general population study design surveyed convenience sample female family planning providers ages years including physicians advanced practice clinicians via internet based survey april may family planning providers compared female respondents ages years national survey family growth results total responses eligible analysis respondents using contraceptive method providers contraceptive use differed markedly general population providers significantly likely use intrauterine contraception implant vaginal ring providers significantly less likely use female sterilization condoms significant differences providers general population use partner vasectomy pill long acting reversible contraception larc use significantly higher among providers general population results consistent stratifying variables including self identified race ethnicity educational level conclusions contraceptive choices sample female family planning providers differed significantly general population findings implications clinical practice patient education health policy elsevier inc rights reserved
structure dynamic neural networks line learning algorithm two important factors naicss nonlinear adaptive inverse control system recurrent neural networks effective identifiers nonlinear plant however complex architecture order simplify structure dynamic neural networks paper proposed improved dafnn dynamic activation function neural network changing neurons structure modified dfann simple feedforward architecture origin one better dynamic ability gradient vectors calculation becomes chief bottleneck learning algorithms dafnns due complex chain rule expansions new line learning algorithm proposed simplify proceeding gradient calculation dafnns paper according signal flow graph theory new algorithm adaptive learning rates guarantee convergence algorithm used learning algorithms identifier controller naicss simulation results show efficient algorithm naicss
recent times cellulose based electro active paper eapap investigated electro mechanical coupling piezoelectric effects promising characteristics smart material paper effects electrodes eapap investigated vibration energy harvesting although piezopolymers smaller value electro mechanical coupling constants compared piezoceramics flexible motivates use materials potential media flexible energy harvesting cellulose based electro active papers deposited different metal electrodes like aluminum gold silver fabricated samples tested aluminum cantilever beam input excitation effects area electrodes also investigated comparing output voltage different area electrodes ranging eapap cantilever tested lowest resonant frequency varying acceleration amplitude maximize output voltage experimental results concluded potential eapap flexible energy harvester promising
lead highly studied contaminant known biological function causes harmful adverse effects ecological human health tried evaluate protective current soil regulatory levels towards safeguarding ecological health order achieve study evaluated effect soil texture toxicity availability lead earthworms soils varying soil properties earthworm eisenia fetida exposed three soils different physico chemical characteristics solutions homogenously mixed soil obtain concentrations ranging dry soil avoidance behaviour weight loss mortality measured study calculate values weight loss mortality earthworms due toxicity following order acidic neutral alkaline soil values resulting decrease worm weight control acidic neutral alkaline soils soil respectively thus acidic soil recorded well soil guideline value whereas values resulting mortality worms control respectively acidic neutral alkaline soils concentrations earthworms ranged wet weight soils low clay content acidic neutral values demonstrated increased toxicity earthworms compared soils alkaline worm weight loss sensitive parameter mortality study emphasizes soil regulatory levels protective worms acidic soils therefore care taken using current regulatory limits assess predict safety contaminated site acidic soils towards ecological health
objective weight loss research focuses weight primary outcome often exclusion physiological psychological measures study aims provide holistic evaluation effects weight loss interventions individuals obesity examining physiological psychological eating disorders outcomes interventions methods databases medline psycinfo cochrane library searched randomised controlled trials systematic reviews obesity treatments dietary exercise behavioural psychological pharmacological surgical data extracted included study features risk bias study outcomes assessment treatment impacts physical psychological eating disorder outcomes results novel records studies met inclusion criteria evaluated review lifestyle interventions strongest evidence base first line approach escalation pharmacotherapy bariatric surgery severe complicated cases quality life common psychological outcome measure improved cases assessed across intervention types behavioural psychological lifestyle interventions weight loss led improvements cognitive restraint control eating binge eating bariatric surgery led improvements eating behaviour body image sustained long term discussion numerous treatment strategies trialled assist people lose weight many effective short term quality life lesser degree depression anxiety psychosocial function often improve alongside weight loss weight loss also associated improvements eating disorder psychopathology related measures although overall eating disorder outcomes rarely assessed research sector collaboration required address significant overlap risk factors diagnoses treatment outcomes obesity eating disorders
background historically smoking cessation thought negatively impact substance use outcomes among smokers use substances sought synthesize recent reports association methods google scholar pubmed cinahl searched studies published march reported impact smoking cessation treatment quitting smoking substance use substance use disorder treatment outcomes general population among substance abuse treatment studies grouped reported impact follows positive improved null change negative worsened results twenty four studies included eighteen reported impact quitting smoking six reported impact smoking cessation treatment intervention independent quitting substance use outcomes eleven studies reported solely positive impact four reported solely null impact eight reported mixed positive null impact analysis combined subgroup substance length follow comparison group one study reported mixed negative null impact ethnic group studies reported increased substance use conclusion smoking cessation appear negative effect often positive effect substance use outcomes smoking cessation advice offered without hesitatkin smokers report substance use treatment substance use disorder elsevier ltd rights reserved
last years many clinical studies revealed cisplatin treated cancer survivors significantly increased risk cardiovascular events cisplatin induced cardiovascular toxicity increasing concern aim present work evaluate cardiovascular alterations induced different chronic cisplatin treatments identify mechanisms involved direct blood pressure basal cardiac left ventricle coronary arteries vascular aortic mesenteric functions evaluated chronic weeks saline cisplatin treated male wistar rats three different doses cisplatin tested week alterations cardiac vascular tissues also investigated immunohistochemistry western blot quantitative pcr analysis cisplatin treatment provoked significant modification arterial blood pressure heart rate basal cardiac function maximum dose tested however vascular endothelial dysfunction occurred lower doses expression collagen fibers conexin increased cardiac tissue cisplatin treated rats doses week expression endothelial nitric oxide synthase also modified cardiac vascular tissues cisplatin treatment conclusion chronic cisplatin treatment provokes cardiac vascular toxicity dose dependent manner besides vascular endothelial dysfunction occurs lower doses cardiac systemic cardiovascular toxicity moreover structural changes cardiac vascular tissues also patent even systemic cardiovascular alterations
currently developed countries already formulated implemented sophisticated category construction laws regulations based development characteristic effectively reducing accident occurrence contrast although china promulgated implemented relevant laws regulations construction projects still many safety problems concerning construction management regard paper author analyzed existing problems construction projects put forward comprehensive management system drawing experience successful construction project management abroad
paper present comparative analysis three survey studies disease prestige medical culture studies conducted using research design three rounds sample norwegian physicians asked rate set diseases scale according prestige believed health personnel general would award results show remarkable stability prestige rank order years top three diseases three surveys leukaemia brain tumour myocardial infarction four lowest ranked fibromyalgia depressive neurosis anxiety neurosis hepatocirrhosis notable change concerns apoplexy brain stroke moved rank three rounds argue stable pattern well change substantiate interpretation previous research prestige disease affected localization affected organ body part effect style typical treatment social attributes typical patient analysing physicians shared evaluations different diseases paper contributes cultural understanding disease conceptions medicine understanding conceptions important disease prestige may influence decision making healthcare sector elsevier ltd rights reserved
paper focus gender classification face images despite advances equipment well methods automatic face image processing recognition even extraction demographics still challenging task unrestricted scenarios tests aimed carrying extensive comparison feature based approach two score based ones directly using features first apply different operators extract corresponding feature vectors stack vectors classified svm based approach using scores different operators applied completely separate way produces corresponding scores answers either fed svm compared pairwise exploit likelihood ratio testbeds used experiments ega database presents good balance respect demographic features stored face images gropus increasingly popular benchmark massive experiments obtained performances confirm feature level fusion achieves often better classification accuracy however computationally expensive contribute research topic three ways show proposed score level fusion approaches though less demanding achieve results comparable feature level fusion even slightly better given fuse particular set experts main advantage feature based approach relying chained vectors required evaluate complex multi feature distribution training process thanks individual training experts overall process efficient flexible since experts easily added discarded final architecture evaluate number uncertain ambiguous cases might cause classification errors depending classification thresholds used show score level fusion significantly decreases despite final rate correct classifications results robust system achieve good results operators computationally expensive elsevier inc rights reserved
gadolinium based contrast agents gbcas used magnetic resonance imaging last three decades recent reports demonstrated gadolinium retention patients brains following intravenous administration since gadolinium highly toxic heavy metal potential adverse effects prolonged retention deposition particularly children reason society spr pediatric radiology quality safety committee conducted survey evaluate current status gbcas usage among pediatric radiologists assess usage gbcas among spr members online question survey distributed spr members survey questions pertained type gbcas used protocoling workflow requirement renal function pregnancy tests various clinical indications contrast enhanced mri examinations total survey responses compiled survey invitations majority academic institutions united states ninety four percent reported studies always usually protocoled pediatric radiologists common gbca utilized survey respondents eovist ablavar gadovist magnevist dotarem several clinical indications survey responses regarding gbca administration concordant american college radiology acr appropriateness criteria including seizures headache osteomyelitis indications including growth hormone deficiency suspected vascular ring survey responses revealed potential overutilization gbcas compared acr recommendations survey results demonstrate gbcas administered judiciously children yet opportunity improve utilization goal reducing potential future adverse effects
background hereditary angioedema hae rare auto somal dominant disorder characterized inh esterase inhibitor low serum levels type dysfunction type normal serum levels function type iii lead subcutaneous submucosal edema attacks aim study investigate demographic clinical laboratory findings iranian patients hae methods patients history symptoms angioedema referred immunology asthma allergy research institute iaari jan jan assessed based specific questionnaire laboratory evaluation patients definite diagnosis hae type type entered study results among patients diagnosed hae type hae type fifteen patients years adults mean age symptoms onset diagnosis years years respectively mean delay diagnosis years commonly involved locations edema hands face genitalia moreover laryngeal edema observed patients led death two patients study conclusion hereditary angioedema life threatening disease considerable morbidity mortality outcomes study used inform clinicians health care providers hae help earlier diagnosis better management patients specifically life threatening attacks
many women information technology careers multiple reasons wanted create workshop targeted middle school girls many opportunities learn computer programming decided female high school college students help teach workshop would allow inspire better connect middle school students workshop used scratch programming language since user friendly require prior knowledge computer programing use many girls came workshop less confidence using technology less interest pursuing technology related careers boys workshop taught students different parts scratch showing function part asking create mini project learned got important aspects scratch asked students create game despite girls thinking experience using technology much less boys end workshop girls created games boys could thereby girls realize programming fun girls mean information technology jobs
realize multipixel camera astronomical observation developed cryogenic multi channel readout systems using gallium arsenide junction field effect transistor gaas jfet integrated circuits ics based experience cryogenic ics designed manufactured demonstrated operational amplifiers requiring four power supplies two voltage sources amplifiers operate open loop gain gain bandwidth product expect khz power dissipation performance evaluations input referred voltage noise rms rms khz respectively noise power spectrum density type extended khz elsevier ltd rights reserved
paper shows review ecdm process basis novel theoretical model novel process novel machine design published elsevier ltd selection peer review responsibility conference committee members international conference materials processing characterization
use electric vehicles long proposed viable alternative conventional cars means tackling transportation challenges related increasing reliance fossil fuel resulting greenhouse gas emissions however considerable barriers effective market uptake still persist one important ones cost compared options car market segment purpose paper assess whether investment pays different car market segments comparisons internal combustion engine cars battery bev undertaken evaluating excess cost consumer evaluation complemented probabilistic risk analysis car market segment found relevant aspect results suggesting acquisition bev higher end car market segment easily become financially attractive option hand cost argument acquiring bev lower middle car market segment still convincing analysis undertaken assuming current portuguese market conditions results deemed pertinent markets regions elsevier ltd rights reserved
assembly design system important part computer aided design systems important tools realizing product concept design traditional assembly design system record connection information production engineering layer consequently upstream design idea fully used downstream design assembly design model based relationship engineering connection presented model nodes divided two categories component connection moreover product constructed basis connection relationship components model graph ability record assembly schemes model records connection information engineering application value product design addition model significantly reduce number combinations favorable assembly sequence planning downstream system contains connection knowledge system mapped connection node connection knowledge obtained practice returned knowledge system finally used develop prototype system called connect based assembly planning cap relationship cap system commercial assembly design system also established
aim study develop treatment diary patients receiving spasticity treatment including botulinum toxin injection physiotherapy occupational therapy diary focuses problems triggered skeletal muscle overactivity agreed goals treatment patient self evaluation achievement goal attainment scale skeletal muscles injected physiotherapists occupational therapists evaluation patients achievement objectives goal attainment scale proposals optimization treatment changing goals evaluation included satisfaction questionnaire qol bref well score overall patients enrolled pilot study patients generally satisfied diary found involved treatment made easier set personal goals found worth time spent using however clear advantage relation quality life qol bref well score reported copyright author published wolters kluwer health inc
although misfolded aggregated alpha synuclein alpha syn recognized disease progression synucleinopathies role impairment cortical circuitries synaptic plasticity remains incompletely understood investigated alpha synuclein accumulation affects synaptic plasticity mouse somatosensory cortex using two distinct approaches long term vivo imaging apical dendrites performed mice overexpressing wild type human alpha synuclein additionally intracranial injection preformed alpha synuclein fibrils performed induce cortical alpha syn pathology find alpha synuclein overexpressing mice show decreased spine density abnormalities spine dynamics age dependent manner also provide evidence detrimental effects seeded alpha synuclein aggregates dendritic architecture observed spine loss well dystrophic deformation dendritic shafts layer pyramidal neurons results provide link pathophysiology underlying dementia associated synucleinopathies may enable evaluation potential drug candidates dendritic spine pathology vivo
work explores feasibility integrating adaptive meta model finite element model updating formulation using dynamic response data bayesian model updating approach based stochastic simulation method considered present formulation approach combined surrogate technique efficient model reduction technique particular adaptive surrogate model based kriging interpolants model reduction technique based substructure coupling implemented integration techniques updating process reduces computational effort manageable levels allowing solution complex problems effectiveness proposed strategy demonstrated three finite element model updating applications
although traditional economic models posit money fungible psychological research abounds examples deviate assumption across eight experiments provide evidence people construe physical currency carrying traces moral history experiments people report less likely want money negative moral history stolen money experiments provide evidence alternative account people judgments merely reflect beliefs consequences accepting stolen money rather moral sensitivity experiment examines whether aversion stolen money may reflect contamination concerns experiment indicates people report would donate stolen money thereby counteracting negative history positive act finally experiment demonstrates even recall actual events people report reduced tendency accept tainted money altogether findings suggest robust tendency evaluate money based moral history even though designed participate exchanges effectively erase origins
prenatal metabolism exerts profound effects development first stool newborn meconium provides window prenatal metabolic environment objective study examine feasibility meconium novel matrix quantify prenatal steroid levels quantified parameters analytical interest regarding use meconium including sample stability hypothesized meconium steroid content would differ sex prompting analysis meconium test effects prenatal steroid metabolism meconium newborns enrolled early autism risk longitudinal investigation earli study including males females analyzed isotope dilution liquid chromatography high resolution mass spectrometry hrms blinded identity testosterone androstenedione dehydroepiandrosterone dhea steroid levels compared sex investigations potential trends resulting sample storage processing conducted unconjugated steroid content meconiuni ngig mean standard deviation males dhea females dhea higher meconium males dhea higher meconium females female male values limit detection extreme variability hydration trend steroid levels storage time detected sexually dimorphic levels hormones may reflect gestational differentiation future studies consider meconium analysis elsevier ltd rights reserved
past decades variety malicious attacks internet discovered attacks packets different network protocols due fast spread attacks difficult people copy immediately consequently packet filtering critical method prevent attacks however packet filtering software solutions satisfy demands contemporary network bandwidth paper propose gpu based multiple pattern matching algorithm filtering malicious packets using bloom filter inspect packet payload leveraging high parallelism computing power gpu experiments compare proposed algorithm different gpu implemented technologies sequence bloom filter algorithm different platforms experimental results demonstrate proposed algorithm significantly enhances performance sequential algorithms
background aim describe relationship risk factors stress depression anxiety potentially protective factors pediatric headache related disability mindfulness resilience self compassion determine teens interest mind body skills training help reduce headache related disability methods cross sectional survey among adolescents seen academic neurology clinic reporting four headaches monthly using standardized instruments determine relationship putative risk protective factors well physiologic markers inflammation vagal tone headache related disability results among participants male average age years average headache frequency per month commonly reported trigger stress risk protective factor significantly associated headache related disability depression depression negatively correlated mindfulness resilience self compassion positively correlated stress sleep disturbance anxiety biomarkers vagal tone inflammation correlated headache related disability depression strong interest learning skills like slow deep breathing practices supported smart phone application reduce stress negative impact headaches daily life discussion among teens frequent migraine headaches depression strongest risk factor headache related disability stress viewed headache trigger teens reported wanting learn simple stress management strategies supported smart phone application help reduce headache related disability
study novel plasma enhanced vapor selenization coupled etching pesvse technique demonstrated achieve uniform depth distribution cigs film significant increase concentration surface cigs film ascribed removal excessive metallic indium plasma pesvse process single phase cigs film obtained without phase separation small grains cracks observed cigs film based pesvse process cigs device obtained pesvse process showed enhanced conversion efficiency compared device obtained tasvs process elsevier rights reserved
aim study analyze mutalion rate jakvf mplwl calr genes adult patients essential thrombocythemia accuracy combined detection receiver operating curve three hundred forty two cases high platelets consecutively selected patients analyzed routine blood examination bone marrow biopsy genetic testing one hundred fifty four cases diagnosed cases secondary thrombocythemia according hematopoietic lymphoid tissue tumor classification standards found mutant type three genes showed three bands whereas one hand wild type jakvf mpl mutations cause change open reading frame calr mutation resulted change mutation rate jakvf calr group significantly higher secondary thrombocythemia group positive mutation rate mpl jakvf positive mutation alone used diagnose area curve auc sensitivity specificity cut value calr positive mutation alone used diagnose auc sensitivity specificity cut value respectively jakvf combined calr mutation used diagnosis auc sensitivity specificity cut values conclusion positive mutation rate jakvf calr higher sensitivity specificity accuracy diagnosis significantly improved using detection jakvf calr
mid fairtrade organic registration data showed oaxaca mexico organic coffee farm operators women female farmer rate increased research investigates impact significant increase women coffee association participation among members two coffee producer associations oaxaca mexico find female coffee organization members report high levels household decision making power likely male counterparts report control coffee income significant advances women agency within household offset fact women experience significant time poverty engage coffee production bearing disproportionate share domestic labor obligations women coffee producers view organizational labor third burden time reproductive productive labor time poverty experience limits ability fully participate coffee organizational governance consequently women leaders levels coffee producer businesses problematic limits women ability fully benefit organizational membership women fully participate governance gain valuable business leadership skills producer associations active female members may also likely develop maintain programs policies enhance gender equity findings indicate targeted agricultural development programs improve gender equity among agricultural smallholders involve creative ways ease women labor burdens reduce time poverty order facilitate full organizational participation research findings fill gap existing studies agricultural global value chains gvcs demonstrating certified coffee gvc depends women paid labor within household also within producer organizations
objectives analyze predictive value psa progression role testosterone quality life qol patients androgen deprivation therapy adt metastatic prostate cancer materials methods psa testosterone data used phase iii trial randomizing patients without progression psa months induction course continuous cad intermittent iad adt year risk progression calculated baseline psa fast slow psa decline days cut oft psa nadir performance status pain testosterone kinetics qol also evaluated univariate kaplan meier survival analysis log rank tests used compare risk progression results progression analysis patients data available year risk progression baseline psa cad iad respectively year risk progression psa nadir cad respectively tad group similar trend seen patients psa nadir though significantly higher year risk progression compared cad respectively psa decline showed predictive value patients without pain significantly lower year risk progression groups without adt testosterone remained castrate level months first second iad cycle respectively normalized testosterone qol difference found although side effects occurred cad conclusions metastatic prostate cancer patients high baseline psa pain high psa nadir poor prognosis adt patients low psa nadir significantly worse tad compared cad low testosterone adt incomplete testosterone recovery may explain similar qol therefore tad good treatment option many metastatic prostate cancer patients elsevier inc rights reserved
full scale test embankment constructed soft deposit kpa improved geotextile encased granular columns assess serviceability performance nearby stockyard foundation behaviour improved foundation monitored means instrumentation respect surface settlements excess pore pressures total vertical stresses acting top encased column surrounding soft soil well geotextile radial deformation two dimensional finite element analysis performed using axi symmetric unit cell results compared field measurements observed soil arching progressed post construction due decrease apparent stiffness soft clay quasi undrained drained stiffness furthermore difference settlement top encased column surrounding soft soil midpoint columns increased construction consolidation stages measured relation also found correlate geotextile expansion maximum settlement occurring embankment
introduction information continuity critical person centered care patients receive care multiple healthcare systems patients access electronic health record data patient portals facilitate information exchange pilot developed improve care continuity rural veterans promoting use department veterans affairs patient portal share health information non providers evaluating impact health information sharing community appointment materials methods veterans nine healthcare systems trained access share continuity care document ccd non providers patients non providers completed surveys experiences results participants primarily older white vietnam era veterans training reported ccd would help involved healthcare planned share regularly non providers veterans attended community appointments provider responses appointments indicated confident accuracy information wanted continue receive ccd ninety percent providers reported ccd improved ability accurate medication list helped make medication treatment decisions fifty percent reported order laboratory test another procedure information available ccd conclusions pilot demonstrates feasibility value patient access ccd facilitate information sharing non providers outreach targeted education needed promote consumer mediated health information exchange
work aims design system ensure availability services services public company municipality florencia caqueta interrupted power loss faulty hardware infrastructure failures data communication virtual servers errors operating systems machines virtual design appropriate system implemented descriptive projectives methods applied research identify failures cause disruption determine requirements new design ensuring availability services company
characterizing highly dynamic transient vertically lofted emissions open area sources poses unique measurement challenges study developed applied multipollutant sensor time integrated sampler system use mobile applications vehicles tethered balloons aerostats unmanned aerial vehicles uavs determine emission factors system particularly applicable open area sources forest fires due light weight compact size internal power supply sensor system termed kolibri consists sensors measuring samplers particulate matter volatile organic compounds vocs kolibri controlled microcontroller record transfer data real time radio module selection sensors based laboratory testing accuracy response delay recovery cross sensitivity precision kolibri compared rack mounted continuous emissions monitoring system cems another mobile sampling instrument flyer used ten open area pollutant sampling events results showed time series concentrations measured kolibri agreed well cems flyer laboratory tested percentage error respectively voc emission factors obtained using kolibri consistent existing literature values relate concentration modified combustion efficiency potential effect rotor downwash particle sampling investigated indoor laboratory preliminary results suggested influence minimal field application kolibri sampling open detonation plumes indicated sensors responded dynamically concentrations varied emission transients kolibri system applied various challenging open area scenarios fires lagoons flares landfills published elsevier ltd
many lung diseases result fibrotic remodelling fibrotic lung disorders divided diseases known unknown aetiology among unknown aetiology idiopathic pulmonary fibrosis ipf common diagnosis progressive character leading rapid decline lung function fatal disease poor prognosis limited therapeutic options thus ipf motivated many studies last decades order increase mechanistic understanding pathogenesis disease current concept suggests ongoing injury alveolar epithelium impaired regeneration capacity alveolar collapse finally fibroproliferative response origin lung injury remains elusive diversity factors discussed article shown associated ipf alveolar epithelial type cells play key role lung fibrosis crucial role epithelial regeneration stabilisation alveoli interaction fibroblasts known responsible collagen deposition illustrated whereas mechanisms collagen deposition fibroproliferation focus many studies field awareness mechanisms disease currently limited biochemical imaging studies including quantitative assessments lung structure ipf animal models assigning alveolar collapse collapse induration crucial roles degradation lung resulting aeration loss surface area dysfunctional cells instable alveoli mechanical stress trigger remodelling consists collapsed alveoli absorbed fibrotic tissue collapse induration
background france negative views schizophrenia pervasive even among health professionals prior research suggests level prejudice lower illness described example specific individual finding highlights importance designing local targeted destigmatization campaigns present study aims evaluate benefits short intervention offering contact psychiatric services users reducing stigma mentally ill people among sample health administrators students methods data collected time time short training intervention program proposed sample health services administrators students four day workshop explained multiple causes mental illness clinical implications psychosis various mental disorders subjective experience mental illness legal evolutions users rights intervention strongly based live testimonies users using french version attitudes mental illness scale compared attitudes training intervention among trainees answered questionnaire time time results training significantly lower endorsement stigmatizing statements compared baseline found one third items results plead research potential benefits initiatives like short intervention program significantly reducing stigmatizing attitudes towards mentally ill people among health administrators students conclusions present study highlights importance studying effect targeted interventions offer first hand contact persons mental illness
article analyses security discourses beginning self consciously take board shift towards anthropocene first sets developing episteme anthropocene highlighting limits instrumentalist cause effect approaches security increasingly becoming displaced discursive framings securing process generated new forms mediation agency capable grasping interrelations fluid context approach methodology hacking creatively composing repurposing already existing forms agency elaborates hacking set experimental practices imaginaries securing anthropocene using case study field digital policy activism focus community empowerment social technical assemblages developed applied city anthropocene jakarta indonesia article concludes policy interventions today readily grasped modernist frameworks problem solving seen terms evolving adaptive life hacks
design construction interface problems impede successful delivery construction projects within specified time cost quality objective paper assess design construction interface problems united arab emirates uae construction industry twenty two problems identified literature review questionnaire survey developed distributed construction professionals thirty nine responses collected consultants contractors construction professionals government authorities weighted average responses calculated results reveal significant interface problems uae include lack coordination inside design firm lack specialist construction manager poorly written contract lack project management individual professional service time limitation design phase moreover paper analysed responses according company role problems caused lack coordination communication among main contracting parties recommendations made enhance coordination management construction projects lead reduction design construction interface problems
explaining constituent groups often vary perceptions salient aspects organization identity existing research drawn almost exclusively social identity research self enhancement motives research suggests different organizational identity categorizations enhancing groups others variation organizational identity perceptions arises paper contrast explore role unmotivated spontaneous cognitions may play influencing variation constituents organizational identity categorizations based data study business school constituents develop dual path model motivated spontaneous processes influence different organizational identity categorizations constituent groups find salient discuss theoretical practical implications findings
research explores intended unintended consequences eating disorder public service announcements assessed participants attitudes toward eating disorders people eating disorders willingness interact people eating disorders experience eating disorders covariate time time participants randomly assigned watch stigmatizing non stigmatizing eating disorder public service announcement exposure stigmatizing public service announcement resulted negative attitudes toward eating disorders less willingness interact people eating disorders significantly negative attitudes toward people eating disorders discussion highlights practical implications health communication campaigns
beta hydroxysteroid dehydrogenase type beta hsd present almost exclusively testes converts androstenedione testosterone beta hsd deficiency rare diagnosis missed early childhood clinical presentation may subtle frequent presentation hsd deficiency individual female external genitalia labial fusion blind ending vagina without clitoromegaly low testosterone androstenedion ratio suggestive beta hsd deficiency diagnosis confirmed molecular genetic studies day newborn referred hospital palpable gonads labia majora physical examination baby female external genitalia palpable gonads labia majora ratio diagnosis beta hsd deficiency confirmed evidence compound heterozygousity novel frameshift mutations exon hsdb gene
mathematical model calculating steady non sinusoidal mode complex electrical network proposed taking account distribution overhead transmission lines parameters suspension geometry brand wires availability overhead ground wire cable way grounding along route line based calculation complex network steady mode fundamental losses accounted caused positive sequence currents fundamental frequency total losses caused actual currents fundamental frequency high harmonic currents wires ground wires paper introduces example steady mode calculation results study effect loss electric power suspension geometry wires overhead ground wire cable
objective health messages tailored applying different tailoring ingredients among personalisation feedback adaptation experiment investigated separate effects tailoring ingredients behaviour auditory health persuasion furthermore moderating effect self efficacy assessed design participants design consisted four conditions generic health message served control condition personalisation applied using recipient first name feedback given personal state message adapted recipient value main outcome measures study consisted pre test questionnaire measuring fruit vegetable intake perceived difficulty performing behaviours indicating self efficacy exposure auditory message follow questionnaire measuring fruit vegetable intake two weeks message exposure results ancovas showed main effect condition either fruit vegetable intake moderation found vegetable intake self efficacy low vegetable intake higher listening personalisation message significant differences conditions found self efficacy high conclusion individuals low self efficacy seemed benefit incorporating personalisation regarding vegetable consumption finding warrants investigation tailoring research
thermal hydraulics supercritical water forced mixed convection natural circulation conditions fully understood order study thermal hydraulic behaviour fluid natural circulation conditions small size closed experimental loop designed built thermal hydraulic phenomenon occurring loop measured thermocouples mounted onto outer surface heated tube wall absolute differential pressure transducers flow meter moreover simultaneously visualized neutron radiography techniques paper describes loop process experiment measurement techniques data acquisition system applied results got first measurement series based results first measurement series found measured part steady state characteristic independent system pressure slight dependence steady state characteristic inlet temperature identified higher inlet temperature higher mass flow rate total pressure drop components seem independent system pressure strongly dependent inlet temperature due influence bulk fluid temperature relevant thermophysical properties density dynamic viscosity pressure drop due acceleration flow found negligible next two dominant components pressure drop due frictional resistance due gravity coupled evaluation radiographic images thermophysical properties wafer shown main driving force behind decrease neutron attenuation decreasing water density bulk fluid temperature increases reverse relationship could exploited validation future monte carlo simulations elsevier ltd rights reserved
widely distributed osteosclerosis unusual radiographic finding multiple causes year old premenopausal spanish woman gradually acquired dense bone diffusely affecting axial skeleton focally affecting proximal long bones systemic lupus erythematosus sle diagnosed adolescence well controlled fractured received antiresorptive therapy hepatitis virus antibody negative family members low bone mass lumbar spine bone mineral density bmd measured dual photon absorptiometry dpa age years receiving glucocorticoids average value age matched controls ages years dual energy ray absorptiometry dxa bmd scores steadily increased lumbar spine femoral neck serum calcium phosphorus levels consistently normal hydroxyvitamin ohd parathyroid hormone pth sometimes slightly increased reduced estimated glomerular filtration rate egfr min hypocalciuria likely reflected positive mineral balance increasing bmd turnover markers serum bone specific alkaline phosphatase alp procollagen type propeptide pnp osteocalcin ocn carboxy terminal cross linking telopeptide type collagen ctx urinary amino terminal cross linking telopeptide type collagen ntx ctx fold reference limits bone formation seemed increased resorption fgf slightly elevated perhaps kidney disease serum osteoprotegerin opg tgf levels normal sclerostin sost receptor activator nuclear factor kappa ligand rankl elevated serum multiplex biomarker profiling confirmed high level sost rankl whereas dickkopf dkk seemed low matrix metalloproteinases mmp mmp elevated iliac crest biopsy revealed tetracycline labels distinction thick trabeculae cortical bone absence peritrabecular fibrosis osteoclasts mastocytosis past years bmd scores steadily decreased skeletal fluorosis mastocytosis myelofibrosis hepatitis associated osteosclerosis multiple myeloma aberrant phosphate homeostasis explain osteosclerosis mutation analysis lrp lrp sost osteopetrosis genes negative microarray showed notable copy number variation perhaps osteosclerosis reflected interval autoimmune mediated resistance sost rankl american society bone mineral research
paper aims develop new method identification power quality events based discrete gabor transform dgt finite impulse response window fir dgt type fuzzy kernel based support vector machine tfk svm fir dgt extracted features input signals tfk svm classified using proper window function dgt essential iterated sine window used window function extract events features iterated sine window function four times faster default window function dgt kernel design main part many kernel based methods svm using tfk total accuracy classification enhanced present work use hybrid approach decreased extracted features size execution time total required memory optimized classification section simulation results revealed accurate classification execution detection classification nine types events overall accuracy proposed method comparable methods accuracy evaluated noisy conditions hardware platform developed evaluating proposed method based arm lpc microcontroller assess accuracy method real conditions
aim case series examine engagement outcomes family based treatment fbt adolescents dsm atypical adolescents underweight presentation consecutive referrals fbt adolescents atypical specialist child adolescent eating disorder program examined engagement treatment dose treatment completion rate changes psychological symptomatology eating disorder symptoms depressive symptoms self esteem obsessive compulsiveness weight menstrual function examined need additional interventions hospitalization medication estimated remission rates also examined sample comprised adolescents aged years female engagement fbt high completing least half treatment dose significant decreases eating disorder depressive symptoms fbt improvement self esteem significant change percent median bmi age gender sample whole however adolescents admitted hospital prior fbt gained weight admitted gain weight fbt overall remission rate ranged depending criteria applied fbt appears effective treatment adolescents atypical however research needed systematic adaptations fbt treatments could improve overall remission rates
gut development phenomenon starts early foetal period continues first months postnatal life structural functional competences acquired prenatal development prepare foetus extra uterine life adaptation nutritional microbial challenges development mucosal immune system occurs early birth passive innate adaptive immune systems confer appropriate protection harmful pathogens along tolerance ubiquitous dietary antigens microbiota number factors related maternal environment gestation lactation likely influence developmental profile gut functions young piglets compromised maternal foetal relations primary causes intrauterine growth restriction induce digestive disorders due gut immaturity moreover establishment intestinal microbiota birth plays important role development neonatal gut immune system factors maternal environment diet composition antibiotic treatment etc induce changes maternal microbiota huge effects offspring gut physiology finally body evidence maternal diet composition may influence colostrum milk composition leading changes gut functions piglets long term impacts early modifications gut physiology piglets prospectively discussed conclusion
background multiple health conditions increasingly problem adults musculoskeletal conditions however multimorbidity research focused primarily elderly limited subset musculoskeletal disorders sought determine whether associations multimorbidity additional burden differ specific forms musculoskeletal conditions among working age adults methods data sourced nationally representative australian survey specific musculoskeletal conditions examined osteoarthritis inflammatory arthritis forms arthritis arthropathies musculoskeletal conditions elsewhere specified gout back pain soft tissue disorders osteoporosis multimorbidity defined additional presence one australian national health priority area conditions burden assessed self reported measures self rated health musculoskeletal related healthcare medicines utilisation iii general healthcare utilisation associations multimorbidity additional health healthcare utilisation burden among working age adults aged years age specific musculoskeletal conditions estimated using logistic regression adjusting confounders interaction terms fitted identify whether specific musculoskeletal conditions multimorbidity strongly associated poorer health greater healthcare utilisation remaining musculoskeletal group results among working age adults specified musculoskeletal conditions multimorbidity associated similar increased likelihood additional self rated health burden certain types healthcare utilisation differences relationships multimorbidity burden specific musculoskeletal conditions one specific musculoskeletal condition appeared consistently associated greater additional health burden presence multimorbidity across majority self rated health burden healthcare use measures conclusions working age people musculoskeletal conditions examined multimorbidity increases self reported health healthcare utilisation burden one musculoskeletal condition appears consistently worse presence multimorbidity need better understand identify strategies acknowledge address additional burden concomitant conditions working age adults range musculoskeletal conditions
symbolic computation important area mathematics computer science many large computations would benefit parallel execution symbolic computations however challenging parallelise complex data control structures dynamic highly irregular parallelism symgridpar framework sgp developed address challenges small scale parallel architectures however multicore revolution means number cores number failures growing exponentially communication topology becoming increasingly complex hence improved parallel symbolic computation framework required paper presents design initial evaluation symgridpar sgp successor symgridpar designed provide scalability onto cores hence also provide fault tolerance present sgp design goals principles architecture describe scalability achieved using layering allowing programmer control task placement outline fault tolerance provided supervising remote computations outline higher level fault tolerance abstractions describe sgp implementation status development plans report scalability efficiency including weak scaling cores investigate overheads tolerating faults simple symbolic computations elsevier ltd rights reserved
order obtain high precision ccd positions himalia sixth jovian satellite total ccd observations obtained years observations made using telescopes administered yunnan observatories nights several factors would influence positional precision himalia analysed including reference star catalogue used geometric distortion phase effect taking advantage unprecedented positional precision recently released catalogue gaia data release chosen match reference stars ccd frames himalia open clusters whichwere observed deriving geometric distortion latest version sofa library used calculate positions reference stars theoretical positions himalia retrieved jet propulsion laboratory horizons system includes satellite ephemeris jup positions jupiter based planetary ephemeris results showed means observed minus computed residuals arcsec right ascension declination respectively standard deviations estimated arcsec direction
prenatal development recognized critical period etiology obesity cardiometabolic disease potential strategies reduce maternal obesity induced risk later life largely overlooked paper first propose conceptual framework role public health preventive medicine inmitigating effects fetal programming second review small growing body research august examines interactive effects maternal obesity two public health foci diet physical activity offspring results review support hypothesis diet physical activity early life attenuate disease susceptibility induced maternal obesity human evidence scant based review identify major gaps relevant prevention research characterizing type dose response dietary physical activity exposures modify adverse effects maternal obesity offspring third discuss potential implications interactions maternal obesity postnatal dietary physical activity exposures interventions mitigate maternal obesity induced risk among children conceptual framework evidence review future research directions offer platform develop test implement fetal programming mitigation strategies current future generations children elsevier inc rights reserved
volumes spatiotemporal trajectory data continue grow rapid pace new generation data management techniques needed order able utilize data provide range data driven services including geographic type services key challenges posed spatiotemporal data include massive data volumes high velocity data captured need interactive response times inherent inaccuracy data propose infrastructure elite leverages peer peer parallel computing techniques address challenges infrastructure offers efficient parallel update query processing organizing data layered index structure logically centralized physically distributed among computing nodes infrastructure elastic respect storage meaning adapts fluctuations storage volume respect computation meaning degree parallelism adapted best match computational requirements infrastructure offers advanced functionality including probabilistic simulations contending inaccuracy underlying data query processing extensive empirical studies offer insight properties infrastructure indicate meets design goals thus enabling effective management big spatiotemporal data
paper propose encryption scheme based phase shifting digital interferometry according original system framework add random amplitude mask replace fourier transform fresnel transform develop mathematical model give discrete formula based scheme makes easy implement scheme computer programming experimental results show improved system better performance security original encryption method moreover demonstrates good capability anti noise anti shear robustness
introduction allergen specific immunotherapy curative approach treatment allergies urgent need improved therapies increase efficacy patient compliance novel routes immunization use advanced vaccine platforms gained heightened interest field areas covered current status allergen specific immunotherapy summarized novel routes immunization challenges clinics critically discussed use nanoparticles novel delivery system allergy vaccines comprehensively reviewed specifically advantages silica nanoparticles vaccine carriers adjuvants summarized expert opinion future allergen specific immunotherapy combine engineered hypoallergenic vaccines novel routes administration skin due biodegradability easiness introduce surface modifications silica nanoparticles promising candidates tailor made vaccines covalently linking allergens polysaccharides silica nanoparticles versatile vaccination platform designed specifically target antigen presenting cells render formulation hypoallergenic introduce immunomodulatory functions combining potent skin vaccination methods fractional laser ablation nanoparticle based vaccines addresses requirements safe efficient therapy allergic diseases
college counseling centers report increased student presentation severe psychological issues gallagher although dialectical behavior therapy dbt demonstrated efficacy multiple clinical populations standard model dbt feasible many traditional college counseling centers article describes iterative development evolution comprehensive dbt program adapted fit scope traditional college counseling center guidelines implementing lessons learned years program provided
grid electrical network performs functions like electricity generation transmission dispatch control operation present grid less efficient due limitations electromechanical nature one way communication centralized generation number sensors actuators manual monitoring restoration limited control etc introduction smart grid phenomenon improvement itc infrastructure management control strategies becoming advanced paper highlights application one smart infrastructure components called smart meter prove feasibility smart management system employing accurate load prediction smart grid
cortical spreading depolarization csd electrophysiologic phenomenon found mostly setting neurologic injury resulting disturbance ion homeostasis leading changes local vascular response bioelectric etiology csd shares similarities epileptic disorders yet relationship seizures csd unclear several studies observing cortical depression seizure activity thus obscuring understanding whether csd activity potentiates limits seizures vice versa cortical sampling exhibited redistribution ion concentrations intra extracellular environments interplay excitation seizures electrical depression csd modeling environments suggested csd synchronizes affected tissue creating favorable environment seizure activity however studies demonstrated opposite epileptiform activity initiating waves csd studies underscored role vascular response subsequent ischemia csd contributes epileptogenesis investigations migraine traumatic brain injury neurologic injuries suggest several drugs may target csd manipulations occurrence nature csd potentially alter threshold seizure activity perhaps minimize immediate long term sequelae associated epilepsy karger basel
rapid increase computational power mobile devices amount ambient intelligence based smart environment systems increased greatly recent years proposition solution described paper namely real time monitoring electrocardiogram ecg signal everyday activities identification life threatening situations paper research review describes previous work authors current state art context authors work proposed aforementioned system although parts solution described earlier publications authors whole concept presented completely first time along prototype implementation mobile device windows tablet modern system three main purposes first goal detection sudden rapid cardiac malfunctions informing people patient surroundings family friends nearest emergency station deteriorating health monitored person second goal monitoring ecg signals non clinical conditions detect anomalies typically found diagnostic tests third goal register analyze repeatable long term disturbances regular signal finding patterns
quantum key distribution qkd schemes rely randomness exchange secret keys two parties control key generate pseudo randomness key exchanging parties increases key exchange rate however use pseudo randomness true randomness required makes classical system vulnerable known plain text attack contrary belief unavailability attack qkd show attack actually possible whenever control key employed paper show possible make use uncertainty principle avoid attack also remove hazards photon number splitting attack quantum setting define secrecy control key based guessing probability propose scheme achieve defined secrecy show general applicability framework common qkd schemes
purpose review breakthrough success capsule endoscopy device assisted enteroscopy inspired researchers test push boundary technologies authors herein summarize latest significant studies clinical impact recent findings competing capsule endoscopy models enriched platform wireless device role capsule endoscopy crohn disease expanding learn significance disease distribution response treatment benefit capsule endoscopy abdominal pain previously sceptical may role device assisted enteroscopy demonstrates significant benefit management patients crohn disease peutz jeghers syndrome contrary long term data suggest endotherapy small bowel angioectasia may beneficial patients thought role device assisted enteroscopy novel territory including coeliac disease endoscopic retrograde cholangiopancreatography continues tested summary limit capsule endoscopy enteroscopy yet reached accumulating long term data alludes benefits current practice spawning novel indications small bowel endoscopy
consider problem group testing sum observations noiseless answers aim locate multiple objects querying number objects sequence chosen sets study probabilistic setting entropy loss assume joint bayesian prior density locations objects seek choose sets queried minimize expected entropy bayesian posterior distribution fixed number questions present new non adaptive policy called dyadic policy show optimal among nonadaptive policies within factor two optimal among adaptive policies policy quick compute nonadaptive nature makes easy parallelize bounds show performs well even compared adaptive policies also study adaptive greedy policy maximizes one step expected reduction entropy show performs least well dyadic policy offering greater query efficiency reduced parallelism numerical experiments demonstrate procedures outperform divide conquer benchmark policy literature called sequential bifurcation show procedures may applied stylized computer vision problem
passive rainwater harvesting technique used design sustainable landscape residential lot located desert design adapted desert southwest region united states based thirty years daily historical climate data including precipitation reference evapotranspiration four cities including paso albuquerque phoenix pahrump selected represent area residential lot broken micro watersheds reflecting runoff water separate portion house roof driveway lawn area paper explains detail design steps one micro watersheds water retention infiltration structures distributed throughout soil area capture stormwater runoff close source passive rainwater capture landscape obtained using stormwater captured infiltration structures stored surrounding soil native vegetation shrubs trees use water exclusively growth plants require watering root establishment period passed except extreme droughts meanwhile stormwater discharge lot decrease groundwater recharge increase results indicate current urban water budget made sustainable replacing watering landscape municipal water harvested stormwater results relatively lush shady environment even desert climates success artifact tendency urban watersheds increase volume stormwater relative pre development conditions
adolescent girls boys use online networking sites differently girls higher risk harmed non adaptive use aim study assess extent adolescents portray according gender stereotypes facebook profiles participants facebook users sexes responded bem sex role inventory bsri personal well index pwi first step adolescents responded bsri respect view typical adult terms gender stereotypes second step half responded bsri respect view half responded respect self presentation facebook results show adolescents consider less sexually differentiated typical adult sex self perception self portrayal facebook study confirms psychological well girls decreases considerably age associated greater degree masculinity conclude adolescents produce accurate self representations facebook profiles boys girls tend offer less sexually differentiated self concept self portrayal typical adult slight preference masculine traits moreover masculinity associated greater degree psychological well
eating disorders serious mental disorders reflected significant impairments health psychosocial functioning excess mortality despite clear evidence clinical significance despite availability evidence based effective treatments research shown paradox elevated health services use yet infrequent treatment specifically targeting eating disorder high unmet treatment need review paper summarizes key studies conducted collaboration terence wilson offers update research literature published since three research areas undergirded collaborative research project unmet treatment needs cost illness cost effectiveness treatments regards unmet treatment needs epidemiological studies find number individuals eating disorder receive disorder specific treatment continues remain high cost illness show eating disorders associated substantial financial burdens individuals family society yet comprehensive examination costs across public sectors lacking cost measures vary widely making difficult draw firm conclusions hospitalization major driver medical costs incurred individuals eating disorder handful cost effectiveness studies conducted leaving policy makers little information base decisions allocation resources help reduce burden suffering attributable eating disorders elsevier ltd rights reserved
speech multisensory percept comprising auditory visual component content processing pathways audio speech well characterized visual component less well understood work expand current methodologies using system identification introduce framework facilitates study visual speech natural continuous form specifically use models based unheard acoustic envelope motion signal categorical visual speech features predict eeg activity silent lipreading results show models performs similarly predicting eeg visual regions respective combinations individual models emv provide improved prediction neural activity constituent models comparing different combinations find model incorporating three types features emv outperforms individual models well models performs similarly model importantly outperform considering higher dimensionality model suggests data needed clarify finding nevertheless performance emv comparisons subject performances three individual models provides evidence suggest visual regions involved low level processing stimulus dynamics categorical speech perception framework may prove useful investigating modality specific processing visual speech naturalistic conditions
study investigates routing aspects battery electric vehicle bev drivers effects overall traffic network performance bevs unique characteristics range limitation long battery recharging time recuperation energy lost deceleration phase equipped regenerative braking system rbs addition energy consumption rate per unit distance traveled lower moderate speed higher speed raises two interesting questions whether characteristics bevs lead different route selection compared conventional internal combustion engine vehicles icevs whether route selection implications bevs affect network performance increasing market penetration bevs questions becoming important study formulates multi class dynamic user equilibrium mcdue model determine equilibrium flows mixed traffic consisting bevs icevs simulation based solution procedure proposed mcdue model mcdue model bevs select routes minimize generalized cost includes route travel time energy related costs range anxiety cost icevs minimize route travel time results numerical experiments illustrate bev drivers select routes lower speed conserve recuperate battery energy icev drivers select shortest travel time routes also illustrate differences route choice behavior bev icev drivers synergistically lead reduction total travel time network performance towards system optimum certain conditions elsevier ltd rights reserved
probiotics may play role aiding digestion patients suffering digestive diseases consumers looking information effectiveness various diseases need find reliable sources answer questions eight internet resources presented provide quality information probiotics effectiveness common digestive diseases
indian education sector grown exponentially last decades per various official reports large amount information pertaining education sector generated every year led requirement managing analyzing structured unstructured information related various stakeholders time need adapt dynamic global world channelizing young talent appropriate domains cognizing deriving knowledge individual student preferences hidden within vast amount education data derived knowledge getting finer information related courses facility quality institutes etc also analyzing unstructured educational learning resources present form multimedia data also desire cater stakeholders decision making related courses admissions career planning etc accentuated big data analytics various mis erp systems handling structured information educational applications exist order aid administration managerial process systems useful customizing software application per institutes courses generating various customizable reports aiding decision making process related institutes need storing maintaining analyzing unstructured information related multimedia content online generated need big data data analytics paper emergence unstructured data comparison features provided relational databases big data identify scope big data indian education sector
aim research design charge pump improve current matching wide range output voltage fast switching operation reduce charge sharing transistor design charge pump proposed simulated cadence virtuoso ade adxl tools cmos technology current mismatching analysed monte carlo simulation output variation calculated pvt designed charge pump achieves wide output voltage swing similar improve current mismatching approximate power dissipation
background skin moisturizing routines part bundle interventions designed prevent skin tears objective evidence based report card reviews effect twice daily moisturization skin skin tear occurrence versus occurrence rates using routine skin care search strategy literature systematically reviewed studies evaluated use standardized skin moisturizers rate skin tears older adults years age professional librarian performed literature search yielded articles following title abstract reviews identified retrieved studies met inclusion criteria findings evidence concerning effectiveness routine twice daily skin moisturizing reducing rate skin tears mixed routine twice daily skin moisturizing significantly result lower incidence skin tears long term care residents compared usual care one study however occurrence skin tears per occupied beds lower moisturizer applied twice daily compared usual care conclusion routine skin moisturizing recommended one component prevention program skin tears among aged adults residing long term care facilities
despite surge psychological research gratitude past several years number important questions remain unanswered highly valued trait largely unknown example gratitude maintained times distress article supports extends existing theory research relevance benefit detection perception received gain rendered intentionally voluntarily another testing model religious involvement general religious coping particular help sustain gratitude face negative emotions across studies community college student sample another among individuals seeking psychological treatment found initial support model implications research gratitude areas positive psychology discussed
valorization converting defatted silkworm pupae dswp microbial lipids oleaginous yeast yarrowia lipolytica investigated obtain best hydrolysis dswp obtain final production cultivation method ultrasound assisted enzymatic pretreatment presence butyl methylimidazolium chloride salt bmim followed trypsin hydrolysis applied pretreat dswp optimal conditions response surface methodology highest weight loss achieved hydrolysis degree lipid yield increased fold respectively adding amount defatted silkworm pupae hydrolysate dswph yeast could produce lipid efficiently besides cost much lower peptone replacement peptone dswp lipid production lipolytica efficiently cut cost microbial lipid production lipid concentration yeast grew medium dswph adding amount increased threefold compared control group citric acid concentration decrease fold given large amount fatty acids accumulation instead citric acid accumulation dswph could replace industrial nitrogen source future practical applications developed enzymatic pretreatment method changed structural dswp assisted using ultrasound bmim application suitable parallel utilization nutrient rich biomass solving problems environmental corruption caused dswp covers analytes effective previously reported methods especially effective cheap safe degradation dswp small moleculars highly desirable suitable nitrogen source replacement peptone dswph better lipid production novel culture medium good lipid production lipolytica reduced cost microbial lipid
humans alterations thyroid hormone signalling associated mood anxiety disorders neural mechanisms underlying association poorly understood present study investigates involvement neuronal thyroid hormone receptor alpha anxiety using mouse genetics cre loxp technology specifically alter tra signalling neurons evaluated behaviour mice expressing dominant negative neuron specific mutation tra alpha ami cre mice using elevated plus maze light dark box open field tests first experiment mice housed individually behaviour alpha ami cre mice differed significantly control littermates tests suggesting heightened anxiety second experiment designed evaluate robustness results tests mice housed groups conditions behaviour alpha ami cre mice differed control littermates light dark box thus alpha ami cre mice appear likely develop anxiety stressful housing conditions control mice results suggest adult mice thyroid hormone signalling neurons via tra involved control anxiety behaviour elsevier rights reserved
purpose compare monotherapy tadalafil tamsulosin combination therapy men benign prostatic hyperplasia erectile dysfunction comparing ipss score prostate volume qmax outcomes materials methods randomized single blind paralleled group clinical trial done patients referred hospital tehran patients lower urinary tract symptoms benign prostatic hyperplasia grade erectile dysfunction recruited randomly divided three groups participants group group received daily tadalafil group received daily tamsulosin group receieved combination daily tamsulosin daily tadalafil primary outcomes prostate volume prostate specific antigen post void residual volume ipss score luts severity qmax iief erectile dysfunction severity secondary outcome complications results mean ultrasonographic prostate volume prostate specific antigen level post void residual level significantly different treatment except group also group meaningful difference compared groups regard significant differences pre post treatment international prostate symptom scores group conclusion combination tamsulosin tadalafil improve international prostate symptom scores international index erectile function questionnaire scores qmax patients lower urinary tract symptoms benign prostatic hyperplasia degrees separate use combination recommended synergistic effects well toleration safety
high physical psychological economic cost sports injuries reason lead recognition need system monitor health parameters professional athlete hence preventing incidences severe injuries athletes sports greatly benefit feedback systems improving quality training paper present architecture cloud based system incorporates wearable motion sensors obtain information health parameters sports athlete provide feedback sports clubs sports organization montenegro sensors placed athlete body predefined positions may capture movements heart rate ecg respiratory data advances wireless technology supporting infrastructure provide opportunity real time healthcare fitness monitoring without constraining activities user wirelessly connected sensors placed around body form body area network continuous unobtrusive monitoring health parameters professional sports athletes
paper presents numerical simulation using plaxis code geosynthetic reinforced embankment locally weak zones case study concerns reinforcement road embankment crosses section sabkha soil chott hodna algeria salt flat dry summer gets flooded winter site observations geotechnical investigations indicated soil sabkha characterised high compressibility low bearing capacity contains locally weak zones limited extent main objective paper assess effect geosynthetic reinforcement settlement embankment locally weak zone influence parameters namely compressibility parameter locally weak zone stiffness geosynthetic locally weak zone geometry friction angle embankment fill also analysed results show computation large displacement suitable small displacement problem differential settlement improvement due combination membrane strength effect geosynthetic arching effect within embankment fill elsevier ltd rights reserved
ethnopharmacological relevance lithospermum erythrorhizon angelica sinensis widely used several folk medicine wound pus discharge dermatitis history several hundred years asian countries aim study investigate therapeutic effect der induced inflammatory response human bronchial epithelial seas cells methods effects der stimulation thymic stromal lymphopoietin tslp nuclear factor kappa kappa pathway inflammasome specifically apoptosis speck like protein asc nod like receptor nlrp caspase signal transducer activator transcription stat pathway evaluated human bronchial epithelial seas cells results results indicated reduced tslp kappa kinase nlrp levels reduced caspase also reduced kappa kappa asc stat levels conclusion aqueous extracts exert anti inflammatory effects der stimulated beas cells effects may involve multiple mechanisms including inhibition tslp production well suppression ikka caspase nlrp however additional studies warranted elucidate underlying mechanisms
parallel resonance circuit equivalent impedance purely resistive value maximum using feature resonant circuit integrated operational amplifier feedback resistor position resonant frequency achieve specific signal frequency selection amplifying design mainly attenuation frequency selection network frequency selection amplifying module automatic gain control module two integrated operational amplifier frequency selection network combination achieve stable resonant amplification amplification resonant frequency mhz using single power supply power consumption observed spectrum analyzer waveform high value smaller rectangle coefficient frequency offset khz bandwidth khz whole system stable output excitation signal output
cognitive deficits pervasive among people schizophrenia treatment options limited increased interest neurocognitive benefits exercise comprehensive evaluation studies date lacking therefore conducted meta analysis controlled trials investigating cognitive outcomes exercise interventions schizophrenia studies identified systematic search across major electronic databases inception april meta analyses used calculate pooled effect sizes hedges cis identified eligible trials cognitive outcome data patients schizophrenia exercise significantly improved global cognition statistical heterogeneity effect size studies randomized controlled trials meta regression analyses indicated greater amounts exercise associated larger improvements global cognition beta interventions supervised physical activity professionals also effective exercise significantly improved cognitive domains working memory social cognition attention vigilance effects processing speed verbal memory visual memory reasoning problem solving significant meta analysis provides evidence exercise improve cognitive functioning among people schizophrenia particularly interventions using higher dosages exercise given challenges improving cognition wider health benefits exercise greater focus providing supervised exercise people schizophrenia needed
frequency response measurements high frequencies shown provide valuable design tool various fields electronics measurements often challenging using commercially available measurement tools due relatively low maximum sampling frequency long measurement time effectively prevents frequency response based low cost applications fast reliable measurements required paper proposes use combined frequency mixer applied pseudo random sequences method applied pseudo random excitation upconverted high frequencies mixer injected device tested system response converted lower frequencies method provides low cost solution applied rapid high frequency measurements using modest data acquisition tools experimental results based high frequency resonator presented used demonstrate effectiveness proposed methods
recently proposed similar goal directed habitual action mediated fronto striatal circuits fronto striato subthalamic pallidal thalamo cortical network may also mediate goal directed habitual automatic inhibition motor non motor domains within framework clinical manifestations parkinson disease dystonia tourette syndrome obsessive compulsive disorder considered represent imbalance goal directed habitual action inhibition possible surgical interventions targeting basal ganglia nuclei deep brain stimulation subthalamic nucleus internal segment globus pallidus improve disorders restoring functional balance facilitation inhibition fronto striatal networks proposals require investigation future studies article part themed issue movement suppression brain mechanisms stopping stillness
previous research suggests established link vertical position self assignment social power affects processing social exclusion hypothesized verticality induced self assignment social power moderates evaluation exclusion via change subjective expectancy social participation following idea superior position associated higher power supposed increase sensitivity transition social exclusion transition simulated virtual ball tossing game cyberball inclusionary block followed partial exclusion participant participants vertical position relative players varied three experimental groups superior even inferior inclusion partial exclusion observed increase event related brain potential related violation subjective expectancy participants reported corresponding increase threat social needs negative mood participants inferior position exclusionary effects need threat less pronounced compared participants even superior position results indicate verticality impacts basic cognitive processes subjective expectancy formation inferior position already provides bias loss social power transition social exclusion less unexpected
semi arid sub humid sub saharan africa highly variable rainfall frequent droughts low water productivity consistently undermining food security rainwater harvesting technologies rwhts help utilise water productively whilst raising yield levels article argued realising potential rwhts resilience building climate adaptation requires better understanding global regional processes influencing rwhts adoption combined pre existing analysis household scale basis systematic literature review processes influence diffusion uptake rwhts identified relate shifting ideology associated food production systems scope investments agriculture science technology emergent actors shaping development assistance patterns farmer mobility drawing insights theory transformations sustainability development article adds understanding connectedness farm level adoption rwhts regional global level actors institutions processes elsevier ltd rights reserved
background aims interstitial pneumonia lymphocytes play important role lung injury involvement integrin alpha beta leukocytes previously reported animal models although integrin alpha beta expression level known regulated inflammatory cytokines involvement interleukin unclear purpose study address possible involvement integrin alpha beta circulating lymphocytes correlation serum interstitial lung diseases ilds methods measured expression levels integrin alpha beta peripheral lymphocytes serum concentration subjects ilds males females years old control subjects males females years old results recombinant regulated expression levels integrin alpha beta healthy human lymphocytes vitro experiment expression levels integrin alpha beta significantly higher acute hypersensitivity pneumonitis non specific nsip compared control serum concentration also significantly increased acute nsip subjects compared control concentration positively correlated integrin alpha beta expression level serum minimal detectable level subjects conclusions findings suggest regulated levels integrin alpha beta systemic lymphocytes elevated serum might involved extravasation lymphocytes
posterior reversible encephalopathy syndrome pres associated several symptoms visual acuity loss light oversensitivity photophobia light flashes photopsia known pres related eye symptoms report post partum woman pres associated hemolysis elevated liver enzymes low platelets syndrome hellp color vision abnormality achromatopsia sole manifestation cesarean section performed weeks due headache epigastralgia severe hypertension hellp became evident delivery post partum day complained achromatopsia stating things look brownish gray ophthalmologic examination normal brain magnetic resonance imaging showed occipital lobe lesions indicative pres interestingly also color vision center area lesions suggesting achromatopsia caused brain damage may prudent question hellp patients concerning achromatopsia
purpose paper present comparative study relational non relational database models web based application executing various operations relational non relational databases thus highlighting results obtained performance comparison tests study based implementation web based application population records non relational database used mongodb relational database used mssql also present advantages using non relational database compared relational database integrated web based application needs manipulate big amount data
rhododendron anthopogon small compact himalayan shrub growing nepal known medicinal plant used treat sore throat colds blood disorders bone disease potato allergies vomiting relieve liver disorders headaches back pain present study investigated chemical composition bioactivities leaf essential oil anthopogon dhankuta nepal essential oil leaves obtained hydrodistillation detailed chemical analysis conducted gas chromatography mass spectrometry enantiomeric distribution monoterpenoid components determined using chiral gas chromatography represents first chiral examination anthopogon essential oil essential oil screened antimicrobial activity using microbroth dilution test cytotoxic activity mcf mda using mtt assay total volatile components identified essential oil major components alpha pinene delta cadinene beta pinene limonene delta amorphene alpha muurolene caryophyllene minor constituents essential oil showed marginal antibacterial cytotoxic activities antifungal effects
paper studied surface quality damage morphology phase transformation yttria stabilized tetragonal zirconia polycrystal tzp cad cam milling subsequent polishing sintering sandblasting processes applied dental restorations ray diffraction scanning electron microscopy sem used scan processed surfaces determine phase transformations analyse surface damage morphology respectively average surface roughness maximum roughness processed surfaces measured using desk top sem assisted morphology analytical software ray diffraction patterns prove sintering induced monoclinic tetragonal phase transformation sandblasting induced phase transformation detected cad cam milling pre sintered tzp produced rough surfaces extensive fractures cracks simply polishing sintering milled pre sintered surfaces significantly improve surface roughness anova neither sintering polishing milled surfaces could effectively improve surface roughness anova best surface morphology produced milling polishing sintering process achieving meets threshold bacterial retention sandblasting intaglios smaller abrasives recommended larger abrasive produced visible surface defects study provides technical insights process selection tzp achieve improved restorative quality elsevier ltd rights reserved
understanding human behaviour activities challenging problem computer vision application areas like health care ambient intelligence use camera feed might seen invasive may resented human behaviour understanding combine images signals feature extraction machine learning techniques paper presents overview technique aims investigate low cost acceptable visual camera monitoring systems elderly main idea limit amount information needs transmitted visual sensor unit proposed technique use filtered images without saving transmitting visual information thus maintaining privacy
software based thread level speculation tls software technique optimistically executes parallel loops whose fully parallel semantics guaranteed compile time modern tls libraries allow handle arbitrary data structures speculatively desired feature comes high cost local store remote recovery times easier local store harder remote recovery unfortunately times critical path tls system paper propose solution performs local store constant time recover values time order number threads see solution together additional improvements makes difference slowdowns noticeable speedups speculative parallelization non synthetic pointer based applications real system experimental results show gain respect baseline system relative efficiency average respect tls implementation specifically tailored benchmarks used
multi level optimisation divides problem sections addressed using appropriate evaluation optimisation processes methodology proposed address design operation building energy system split three levels building design system design system operation optimisation techniques used multi objective genetic algorithm design mixed integer linear programming operation evaluation methods used building energy simulation program energyplus building level energy hub model system level objective functions used annual carbon emissions initial capital cost multi objective design problem annual running costs single objective operational problem methods used described detail proposed methodology applied case study concerning office building detailed results presented include trade front optimal design level solutions convergence optimisation trends associated design variable values derived properties solution operational variable values run times operational optimisation conclusions drawn regarding case study overall approach future directions suggested elsevier ltd rights reserved
background aims use exogenous hormones form oral contraceptives ocs linked consistently risk crohn disease nonetheless clear ocs might contribute progression methods conducted prospective study female patients age identified inpatient outpatient care components swedish national patient register january december information current use obtained prescribed drug register starting july updated december primary outcomes defined first related surgery first steroid prescription used cox proportional hazard modeling time varying covariates estimate multivariable adjusted hazard ratios adjusted hrs results identified incident cases surgery among patients median follow period months compared nonusers adjusted hrs surgery confidence interval past users current users risk surgery increased longer duration use trend higher prescribed daily dose trend specifically women years use adjusted surgery association confined combination type estimated every patients receiving combination type oral contraceptives least year extra surgery required rate steroid prescriptions appear increase past current use ocs compared patients taken ocs pcomparisons conclusions nationwide analysis patients sweden long term use ocs particularly combination type associated increased risk surgery among women established clinicians carefully evaluate monitor contraceptive options among women established
study examined gender differences among homeless young adults coping strategies homelessness stressors relate legal full time employment selling personal possessions selling blood plasma illegal economic activity selling drugs theft prostitution sample homeless young adults recruited cities los angeles austin denver participate semi structured interviews march july risk resilience correlates legal illegal economic activity analyzed using six ordinary least squares regression models full sample female male sub samples full sample three variables avoidant coping problem focused coping mania associated legal income generation whereas eight variables social coping age arrest history transience peer substance use antisocial personality disorder aspd substance use disorder sud major depressive episode mde associated illegal economic activity female sub sample three variables problem focused coping race ethnicity transience correlated legal income generation whereas six variables problem focused coping social coping age arrest history peer substance use aspd correlated illegal economic activity among males model depicting legal income generation significant yet seven variables social coping age transience peer substance use aspd sud mde associated illegal economic activity understanding gender differences coping strategies economic activity might help customize interventions aimed safe legal income generation population elsevier ltd rights reserved
background aim study evaluate relationships cypc cox genetic polymorphisms therapeutic efficacy non steroidal anti inflammatory drugs nsaids treatment ankylosing spondylitis material methods enrolled inpatients outpatients arthritis rheumatism department peking university first hospital healthy people getting routine check ups september july cypc cox genetic polymorphisms detected pcr rflp patients underwent medical treatment week follow treatment score differences basdai asas asas asas patients different genotypes treatment compared results terms cox gene polymorphism genotype allele frequency case group control group obviously different patients improved basdai asas asas asas scores received nsaid treatment furthermore efficacy nsaid treatment cox gene polymorphism associated conclusions cox polymorphism may increase risk considered biological indicators prediction efficacy nsaids treatment
objectives although violent behaviour psychopathology often occur little research psychiatric disorders among men treatment intimate partner violence ipv study aimed examine prevalence broad spectrum psychiatric disorders among men voluntarily attending treatment ipv setting clinics ipv treatment located east south west norway participated study cross sectional design men attending therapy violence partner went face face structured diagnostic interview mini international neuropsychiatric interview participants men contacted clinic inclusion period men attend men referred outpatient clinics men offered therapy provide consent participate study excluded men missed interview results total men participated study majority ethnic norwegians total men fulfilled diagnostic criteria least one ongoing psychiatric disorder three categories disorders stood approximately equal prevalences depressive disorders anxiety disorders including post traumatic stress disorder alcohol substance abuse antisocial personality disorder present approximately participants comorbidity high nearly half men assigned two diagnoses conclusions men voluntarily admitted treatment ipv harbour wide spectrum psychiatric disorders findings suggest need screening procedures psychiatric disorders well adoption treatment interventions according different types psychopathologies therapeutic needs limitations include caution terms generalisation populations voluntarily admitted treatment ipv risk ignoring symptoms covered clinical structured interview
roots abrus precatorius fabaceae traditionally used vietnam china treatment inflammatory diseases stomatitis asthma bronchitis hepatitis therefore study isolated methoxylonchocarpin anti inflammatory compound present studied anti inflammatory effects mice trinitrobenzenesulfonic acid tnbs induced colitis lipopolysaccharide lps stimulated macrophages found inhibit nuclear factor kappa activation tumor necrosis factor tnf interleuldn expression inhibiting lps binding toll like receptor tlr vitro oral administration mice tnbs induced colitis suppressed colon shortening colonic myeloperoxidase activity treatment significantly inhibited activation nuclear factor kappa phosphorylation transforming growth factor beta activated kinase colon treatment also inhibited tnbs induced expression beta tnf reduced tnbs induced expression macrophage markers arginase tnf found increase expression macrophage markers arginase conclusion oral administration attenuated colitis mice inhibiting binding lps tlr immune cells increasing polarization macrophages macrophages elsevier rights reserved
two studies examined whether belief occurrence events recollecting events belief accuracy recollections distinct aspects autobiographical remembering study student participants received cue recall five childhood events rated event constructs characteristics associated remembering structural equation modelling revealed variance ratings best explained three anticipated latent variables study online sample adults recalled rated childhood event event somehow uncertain confirmatory modelling replicated three latent variables relationship key predictors perceptual detail spatial detail experiencing event plausibility latent variables confirmed distinction studies demonstrate belief occurrence belief accuracy appraisals distinct former indexing truth status event latter degree event representation accurately reflects prior experience suggest belief accuracy indexes monitoring quality recollections elsevier rights reserved
examined neural activity associated true false recognition encoding retrieval using remember know procedure separate recollection mental reinstatement experienced events unique details memory recalled familiarity mental awareness event experienced previously without unique details event recognition memory neuroimaging data retrieval revealed right parahippocampal gyrus activated recollection based true recognition compared familiarity based true recognition indicating item specific retrieval visual details effect right parahippocampal gyrus observed false recognition contrary expectation reactivation effect early visual cortex observed true recognition opposed false recognition neuroimaging data encoding revealed right visual cortex right occipitotemporal sulcus activated encoding items yielded recollection based true recognition compared familiarity based true recognition indicating item specific visual processing effect right visual cortex observed false recognition results suggest subjective feeling remember know respect veridical false memories varies neural activity encoding retrieval authors published elsevier ireland ltd japan neuroscience society rights reserved
cyclical mood disorders characterized shifting affective states include bipolar disorder seasonal affective disorder premenstrual syndrome premenstrual dysphoric disorder article explore relationship disorders bring reader date advances made past year understanding relationship bipolar disorder seasonality premenstrual symptoms
paper establish regularity criterion terms temperature fractional boussinesq equations zero heat conductivity
tomographic images spatial distribution electron density ionospheric region presented russian american tomography experiment rate november well campaigns carried northern scandinavia november russia april reconstructions selected display ionisation troughs tomographic chains receivers geomagnetically quiet disturbed periods two mathematical models high latitude ionosphere developed polar geophysical institute applied interpretation observed tomographic images
sports injuries frequently involve tendons muscles ligaments variable outcome surgery medical treatment support early functional treatments eccentric exercise showed effectiveness management achilles tendinopathy patellar tendinopathy lateral epicondyle tendinopathy let preliminary results tendinopathies sports injuries suggest wide prescription sport rehabilitation field comprehensive search pubmed web science cochrane collaboration database physiotherapy evidence database pedro evidence based medicine ebm search review national guidelines scopus google scholar performed using keywords eccentric exercise sports injuries rehabilitation tendinopathy hamstrings strain adductor injuries acl reconstruction rehabilitation alone associated therapies represents feasible cost effective successful tool treatment well known targets might promising shoulder tendinopathy adductor related groin pain hamstring strains acl rehabilitation lack standardization protocols variable amount quality follow studies different anatomy pathophysiology therapeutic targets limit evidence applicability sports injuries role pathology biomechanics response investigated new randomized controlled trials test effectiveness standardized regimens various sites sports injuries
recent years sparse representation theory attracted attention many researchers signal processing pattern recognition computer vision communities choice dictionary matrix plays key role sparse representation based methods pre defined dictionary learned via optimization procedure furthermore dictionary learning process extended non linear setting using appropriate kernel function order handle non linear structured data framework choice kernel function also key step multiple kernel learning appealing strategy dealing problem paper within framework kernel sparse representation based classification propose iterative algorithm coincident learning dictionary matrix multiple kernel function weighted sum set basis functions considered multiple kernel function weights optimized reconstruction error sparse coded data minimized proposed algorithm sparse coding dictionary learning multiple kernel learning processes performed three steps optimization process performed considering two different structures namely distributive collective sparse representation based classifier experimental results show proposed algorithm outperforms existing sparse coding based approaches results also confirm collective setting leads better results number training examples limited hand distributive setting appropriate enough training samples
propose algorithm electrical source imaging epileptic discharges takes data driven approach regularizing dynamics solutions method based linear system identification short time segments combined classical inverse solution approach whereas ensemble averaging segments epochs discards inter segment variations averaging across approach explicitly models indeed may even possible avoid need time consuming process marking epochs containing discharges altogether demonstrate approach produce stable accurate inverse solutions experiments using simulated data real data epilepsy patients illustrative example show able image propagation using approach show applied imaging seizure data approach reproducibly localized frequent seizure activity within margins surgeries led patients seizure freedom approach could used planning epilepsy surgeries way localize potentially epileptogenic tissue resected
secure sanitary water supply essential human health well challenges meeting demand great small island developing states water resources may limited due social environmental constraints honiara solomon islands number factors constrained access fresh water including rapid population growth urbanisation neglected water infrastructure ethnic tensions water tariff increases past years sole reliance groundwater poor supporting electrical infrastructure within context case using rainwater tanks either predominant source augmentation existing domestic water supply explored effect historical drought events rainwater tanks examined water balance model developed various household scenarios reviewed determine reliability domestic rainwater tanks year period development model highlighted opportunities limitations honiara used inform decision makers planners water resources management
background nonalcoholic fatty liver disease nafld one leading causes chronic liver disease worldwide tremendous clinical burden economic burden nafld well studied goal assess economic burden nafld study medicare beneficiaries january december nafld diagnosis international classification diseases ninth revision codes absence liver diseases selected inpatient outpatient resource utilization parameters total charges total provider payments nafld patients compensated cirrhosis compared decompensated cirrhosis results total inpatients outpatients nafld included white male cardiovascular disease cvd metabolic syndrome conditions cirrhosis inpatients median total hospital charge nafld patients cirrhosis higher charges payments noncirrhotic nafld patients compared nafld patients higher charges payments outpatients median total charge nafld patients cirrhosis higher charges payments noncirrhotic nafld patients compared patients higher total charges multivariate analysis variables associated increased inpatient resource utilization inpatient mortality cvd outpatients cvd obesity hypertension conclusions nafld associated significant economic burden medicare presence cirrhosis cvd associated increased resource utilization
background four free one care policy hiv aids related free services place china since however linkage human immunodeficiency virus hiv care yet achieved well among people living hiv conducted qualitative study explore individual contextual factors may influence linkage hiv care perspective young hiv infected men sex men msm highly centralized hiv care context china methods purposive sampling used recruit hiv infected msm shandong province depth interviews conducted march july thematic content analysis subsequently used data analysis results key barriers facilitators related linkage hiv care emerged participants narratives barriers included perceived healthy status low health literacy stigma associated receiving hiv care facilitators included awareness responsibility knowledge associated health literacy social support trusting relying services provided center disease control prevention cdc government related quality current hiv counselling testing service promotion cost placement hiv services conclusions order improve msm linkage hiv care china imperative improve quality current going counselling testing critical linkage support includes increasing supportive services among local cdc systems designated hospitals community based organizations cbos financial support hiv aids related testing medical checkups treatments
substantial research indicated media violence induces short long term increases aggressive thoughts feelings behaviors recently neuroimaging techniques begun identify mechanisms driving changes important avenue neuroimaging tools address exposure media violence childhood affects brain development lifelong behavioral consequences review highlights neuroimaging research examining media violence exposure affects pediatric brain research limited evidence suggests prefrontal mechanisms controlling emotion behavior altered exposure violent media therefore long term increases aggression decreases inhibitory control due excessive media violence exposure may result impaired development prefrontal regions however additional neuroimaging research necessary establish whether exposure media violence specifically shapes subsequent neural maturation optimize use neuroimaging inquiry imaging studies stand instead must integrated traditional research paradigms establish complete picture effects future research must employ longitudinal approaches better characterize long term effects high exposure violent screen media may brain development particularly prefrontal limbic brain regions
purpose focus paper environmental protection specifically within context green building institutions higher education ihes one major reason many ihes undertaking sustainable building policies barriers adoption lack efficiency caused barriers adoption campus green building examined purpose paper identify common barriers adoption green building initiatives ihes multiple stakeholder perspectives propose possible solutions design methodology approach manuscript provides general review lack efficiency caused barriers adoption sustainable building policies tertiary education institutions findings campus sustainable building policies face various barriers adoption green building policies campus sustainable building policies face various barriers adoption include lack awareness among many stakeholders incentives champions understanding financial considerations occupant satisfaction barriers addressed review student perceptions encouraging knowledge gains larger wealthier ihes campus planning offering financial motivations employing campus sustainability officer marketing green campus building initiatives however every stakeholder needs part collaboration incentivized order reduce barriers practical implications manuscript helpful campus community members involved crafting implementing managing green building policies green building development contemporary issue among higher education sector research prove helpful decision makers identifies barriers solutions barriers furthermore research assist practitioners attempting implement green building policies respective ihes helping understand barriers well potential solutions barriers campus green building originality value general review uncovers barriers green building higher education sector sector historically dearth green building research furthermore solutions offered address overcome barriers multiple stakeholder perspectives within sector
polycystic ovary syndrome pcos common endocrine condition women often anecdotally associated binge eating behaviours food cravings however paucity research study aimed report prevalence binge eating food cravings relation obesity risk women pcos participants completed online survey including bulimia investigatory test edinburgh food cravings trait questionnaire three factor eating questionnaire revised study included obese overweight lean women pcos lean healthy women sixty percent obese women pcos categorised binge eating behaviour presenting clinically significant behaviour obese women pcos presented high mean food cravings trait scores significantly greater compared lean overweight women pcos multiple regression exploring relations eating styles adiposity explained variance binge eating symptom scores women pcos significant predictors food cravings total score beta emotional eating score beta body mass index beta uncontrolled eating score beta compared lean healthy women lean women pcos exhibited significantly higher binge eating symptom scores versus though similar total food craving scores versus study largest date robustly report high proportion women pcos exhibit binge eating behaviours recommend screening women pcos binge eating behaviours help inform choice weight management approach clinical population elsevier ltd rights reserved
background laboratory scale two chamber microbial fuel cell employing aerated cathode catalyst inoculated mixed inoculum acetate carbon source electrochemical impedance spectroscopy eis used study behavior mfc initial biofilm week maximum power density week eis performed anode chamber biofilm without anolyte anolyte without biofilm nyquist plots eis data fitted two equivalent electrical circuits estimate contributions intrinsic resistances overall internal mfc impedance weeks respectively results results showed system tended increase power density week week current density week week samples identified pyrosequencing rrna gene showed initial inoculum week constituted proteobacteria bacteroidetes firmicutes week proteobacterial species predominant electricity generation anode biofilm rhodopseudomonas palustris meanwhile anolyte firmicutes phylum predominant bacillus study proved experimental conditions used important contribution interaction biofilm anolyte cell performance table presents summary specific influence element system study conclusions results showed certain members bacterial electrode community increased relative abundance initial inoculum example proteobacterial species important electricity generation anode biofilms firmicutes phylum predominant anolyte transfer electron three systems variation observed time biofilm makes significant contribution charge transfer processes electrode cdl consequently performance anode chamber biofilm act barrier reduces diffusion anolyte towards electrode behaving like porous material anolyte interaction biofilm exert considerable influence diffusion processes given presents highest values increased week
synadenium grantii frequently used treatment various diseases allergies gastric disorders especially cancer aim study evaluate possible antiproliferative potential methanol extract fractions pure compounds stems grantii phytochemical analysis carried conventional chromatographic techniques antiproliferative activity analyzed using sulforhodamine assay mtt based assay nonpolar fraction subfractions stems grantii exhibited promising cytostatic effect several human tumor cell lines glioma breast kidney lung total grown inhibition values ranging one active principles plant identified rare phorbol diterpene ester denoted tetraacetylphorbol phenylacetate compound demonstrated antiproliferative activity glioma kidney lung triple negative breast cancer cell lines results demonstrate grantii stems produce active principles relevant antiproliferative potential
problem statement study gender peculiarities discursive description gender linguistics aspects nonverbal communication norms differences similarities behavior men women different countries research questions emotional peculiarities genders study identification emotional state according gender linguistics nonverbal means purpose study study emotional state women men facial expressions degree control nonverbal behavior cultural indicator emotional state expressed nonverbal means contributes disclosure inner world aesthetic appreciation personality gender linguistics research methods used discursive comparative descriptive analyses classifying features behavioral state men women universal types emotion external indicators nonverbal communication similarities differences different countries explained diversity mental states actions reactions disclosure individual state gender linguistics findings positive achievements cross cultural communication emotional state gender discursive description intonation variety mental states characteristics contribute better understanding gender psychology linguistics human ability identify basic emotions nonverbal displays universal data show women rights men conclusions study focuses problems discursive description gender linguistics new actual theme philological science nowadays concept gender scientific trend define social place women men society authors published cognitive crcs responsibility author
large scale relational databases normally large size high degree sparsity made database compression important improve performance save storage space using standard compression techniques syntactic gzip zip take advantage relational properties techniques look nature data since semantic compression accounts exploits meanings dynamic ranges error individual attributes lossy compression existing data dependencies correlations attributes table lossless compression effective table data compression inspired semantic compression study proposes novel independent lossless compression system utilising data mining model find frequent pattern maximum gain representative row order draw attribute semantics besides modified version augmented vector quantisation coder increase total throughput database compression algorithm enables granular suitable every kind massive data tables synthetically considering compression ratio space speed experimentation several large real life datasets indicates superiority system respect previously known lossless semantic techniques
thought disorder long associated schizophrenia widely recognized symptom mania psychotic disorders well previous studies suggested found clinically unaffected relatives schizoaffective bipolar probands qualitatively similar found probands examine quantitative measures optimize distinction patients diagnoses bipolar disorder psychotic features nonpsychiatric controls addition investigate whether measures also distinguish respective clinically unaffected relatives relsz relbp controls well find deviant verbalizations significantly associated familial clinically unaffected relsz dissociated familial disorder contrast combinatory thinking nonspecifically associated psychosis aggregate either group relatives results provide support usefulness identifying potential non penetrant carriers risk genes turn enhancing power genetic analyses findings also suggest refinement phenotype may needed order suitable use genetic studies bipolar disorder
purpose vestibular system part inner ear responsible balance vertigo dizziness generally caused vestibular disorders common symptoms people years old one efficient treatments moment vestibular rehabilitation permitting improve symptoms however rehabilitation therapy highly empirical process needs enhanced better understood methods work studies vestibular system using alternative computational approach thus part vestibular system simulated three dimensional numerical model first time using combination two discretization techniques finite element method smoothed particle hydrodynamics method possible simulate transient behavior fluid inside one canals vestibular system results obtained numerical results presented compared available literature fluid solid interaction model occurs expected methods applied results obtained semicircular canal model boundary conditions similar solutions obtained authors conclusions numerical technique presented represents step forward biomechanical study vestibular system future allow existing rehabilitation techniques improved
vulnerability water environmental defined measure degree water pollution susceptibility resilience influence human activities natural causes analysis study indicates water environment humid intensive human activity area southern china vulnerable water quality water quantity vulnerability water environment key element water security regions study provided new approach quantify vulnerability surface water environment humid areas case study southern china taking pollution water environment input output process classic data envelopment analysis method dea often used management science introduced establish evaluation model access vulnerability surface water environment analysis results water resources districts pearl river basin china using sea method showed majority water resources districts abundant water resources greater carrying capacity less vulnerable shortage water resources contamination water environment
cannabis sativa sativa well known medicinal industrial recreational use however allergies relation cannabis sativa sativa rarely reported sativa one common weeds found pakistan pollen grains common spring fall season although categorized aeroallergen limited number reports regarding allergenic potential sativa therefore current study aimed exploring ige binding potential among sativa pollen local pollen allergic patients initial screening sativa sensitized individuals carried dot blot sera pollen allergic patients proteins pollen grains extracted resolved gel eight bands visible gel however one protein fragment kda size found bind ige analyzed protein gel blot analysis strong ige affinity kda protein fragment sativa pollen extract suggests allergenic potential study required find exact nature protein fragment
yuyang coal mine drainage potentially negative impact surrounding drinking water including hongshixia water source causing detrimental effects environment human health contamination coal mine analyzed physicochemical interpretation numerical simulation constructed two sampling profiles along groundwater flow transverse directions collected twenty six groundwater samples near drainage ponds yuyang coal mine physicochemical analysis interpretation terms numerical simulations chose modflow software describe river drainage ponds reservoir establish flow model chose mtdms modular software build solute transport model established three dimensional transient numerical model predict migration total physicochemical analytical results indicate groundwater quality degrades approach drainage ponds variations ion concentrations eastward northward directions show migration distance contaminants eastward direction direction groundwater flow much greater northward direction perpendicular groundwater flow direction numerical simulation results suggest within predicted days concentrations mine drainage ponds higher acceptable levels recommended national groundwater quality guidelines imposing serious risks surrounding groundwater human health pollution plumes contaminants migrate closer groundwater source governed groundwater flow suggesting mine drainage may pose risk groundwater quality hongshixia water source
longitudinal study investigated predictive value trauma mental health problems development antisocial personality disorder aspd borderline personality disorder bpd previously detained women participants detained adolescent females assessed traumatic experiences mental health problems mean age years three years later aspd bpd diagnosed semistructured interview forty percent women personality disorder aspd bpd aspd bpd posttraumatic stress depressive symptoms dissociation detention increased risk bpd adulthood surprisingly neither conduct problems substance dependence predicted aspd findings require study add controversy surrounding aspd females high prevalence rates personality disorders indicate need intervention programs target unwanted outcomes
recent years aromatherapy become increasingly popular clinical treatment therapeutic management acute chronic stress targets distinct unique neurobiological characteristics olfactory system tightly linked emotions information processing well autonomous nervous system yet depending mode application aromatherapeutic interventions show varying degrees therapeutic effectiveness series five experiments effects new mode aromatherapeutic application inhaler investigated specifically designed directly stimulate olfactory system reduce activity sympathetic nervous system overall application inhaler showed consistent large psychological physiological effects also clearly outperformed stress management techniques like progressive muscle relaxation bach flowers passive resting periods natural control effects occurred shortly inhalations drastically reduced stress related biomarkers blood pressure heart rate cortisol considerably enhanced well copyright john wiley sons ltd
existence matrix representations given finite dimensional complex lie algebra classic result lie theory particular representations obtained means isomorphic matrix lie algebra consisting upper triangular square matrices unfortunately general information minimal order matrices involved representations way main goal revisit debug implement algorithm provides minimal order matrix representations finite dimensional solvable lie algebra inserting law well returning matrix representative algebra using minimal order previously computed order show applicability procedure computed minimal representatives solvable lie algebra dimension less also solvable lie algebras arbitrary dimension elsevier rights reserved
cretaceous section parnaiba basin designated grajau basin represents intracontinental half graben formed early cretaceous due separation south american african continents final dispersal western gondwana synergetic approach fluid inclusion planes flps outcropping geologic structures borehole breakouts remote sensing data elucidate different scales main structural features kinematic indicators normal faults strike mainly nne ssw wnw ese deformation bands extension joints trend flps wnw ese addition normal fault generated scarps border geomorphological units constitute dense zones deformation bands fluidization microthermometric fip analyses suggest fracturing event occurred shallow basin levels temperatures degrees furthermore joints bands flps present mutually cross cutting relationships thus indicating contemporaneity numerical inversions applied striated faults non striated faults joints deformation bands flps suggest occurrence extensional event characterized variable direction extension sigma trending wnw ese nne ssw event probably started albian final gondwana fragmentation stages quasi perpendicular sigma trend could caused one following phenomena stress ratio values obtained indicate possibility radial extension sigma approximate sigma perhaps response deformation partitioning due kinematic simple shearing constraints along equatorial atlantic transform margin along wnw oriented release normal faults local extension nne ssw switch positions relation regional extension wnw ese rotating degrees influence pre existing structures regional stress field thus spatial temporal relationships cretaceous fault activity stress field development geomorphological features grajau basin contribute understanding brazilian equatorial margin geodynamics elsevier rights reserved
component based development object oriented software modularization depends packages structured organized packages evolve time require structuring time understandability maintainability gets improved paper new approach package restructuring named change history based package restructuring chpr introduced identify proper package regrouping possibilities chpr approach considers past change patterns packages along structural coupling series experiments open source software systems performed preliminary results show chpr approach able indentify meaningful package restructuring
last decades increasing urban development coastal areas produced extensive modifications shores world making critical active management pressures sandy beaches use engineering solutions counteract beach erosion significantly increasing ecological indicators used monitor interventions generally focus short medium term effects little known effectiveness long term temporal scales following ecological indicators tested present study macrofaunal community abundance diversity orientation behaviour talitrus saltator talitrid amphipod widespread mediterranean european atlantic sandy beaches two sites considered sandy beach portuguese atlantic coast one located front natural dune distance dune rebuilt using geotextile tubes macrofauna sampling orientation experiments saltator performed sites spring autumn contemporaneously main environmental variables registered macrofaunal data analysed multivariate statistical tests orientation distributions circular statistics calculated multivariate analyses angular data performed geotextiles appeared successful stabilising recovered dunes accordingly diversity macrofaunal communities orientation performances saltator showed differences altered control sites significant reductions nevertheless observed artificial dune site regarding abundance saltator lesser extent macrofaunal densities likely ascribable presence geotextiles instead vegetated natural dune preventing invertebrates burrow sand results complementing comprehensive study two sites indicate abundance saltator best indicator follow long term effects kind soft engineering intervention use bioindicator may recommended late phases monitoring procedures dune recovery processes elsevier ltd rights reserved
present study aimed examine professionals experiences perceptions knowledge regarding violence exposed children order clarify status opportunities children swedish legal system questionnaire distributed professionals representing police prosecutors social personnel treatment personnel findings revealed several problems hindered effective work routines guidelines lacking knowledge gaps regarding children found among professions perceptions children remember tell widely held although conditions enabling sufficient reports seldom met results used guide necessary changes national routines guidelines ensure recovery maintaining societal rights group psychologically abused victims
explore benefits using online autotuning find optimal configuration parallel construction surface area heuristic sah trees using quickly converging autotuning mechanism achieve significant performance improvement sah tree spatial data structure fundamental tool domain computer graphics simulations parallel construction trees influenced several parameters controlling various aspects algorithm however parameter configurations advocated literature hardly ever portable boost portability apply online autotuning four state art variants parallel tree construction show speedups variants standard configurations possible low programmer effort demonstrate performance portability approach evaluating performance varying multicore platforms static dynamic geometries
background dry skin common skin condition childhood studies exist investigating influence daily skin care dry skin infants risk developing atopic dermatitis aimed assess effect skin care dry skin special cohort using validated scores analysis skin microtopography methods children randomized group group infants group weeks applied daily plant based emollient petrolatum based emollient core outcome assessed severity scoring atopic dermatitis scorad patient oriented scoring atopic dermatitis scorad influence parents life evaluated questionnaire microtopography visioscan results scorad index declined significantly week groups sleeplessness score analyzed scorad highly reduced influence parents anxiety reduced visioscan parameter scaliness strongly diminished groups conclusions trial demonstrates improved skin conditions sleep following daily emollient application infants children dry skin risk especially parents infants showed reduced fear children might develop studies required investigate preventive effect daily emollient therapy special cohort evaluating outcome measures used trial karger basel
intravesical botulinum toxin bont safe effective treatment overactive bladder syndrome many reports clinical experience bont especially patients neurogenic detrusor overactivity food drug administration recently approved use idiopathic overactive bladder ioab various studies reported positive results ioab short term yet little known results repeated bont injections study evaluated long term results botulinum toxin bont women ioab patients treated bont evaluated non academic teaching hospital zuyderland heerlen netherlands female patients follow years idiopathic bladder dysfunction included patients received onabotulinum toxin intradetrusor injections patients applied dose adjustment repeated injections patients instructed use clean intermittent self catheterization cisc treatment advised patients commence cisc post void residual exceeded total women included patients least year follow first injection mean follow months mean age years patients still bont treatment last follow visit discontinued treatment insufficient effect tolerability issues patients discontinued treatment first second injections patients discontinued treatment two injections follow intravesical bont effective treatment women idiopathic oab however time almost two thirds patients study discontinued therapy patients discontinue treatment one two injections mainly due tolerability issues
one vulnerable coasts world climate change bangladesh india facing new challenges protect sundarban largest mangrove world adverse impacts climate driven changes study unsupervised classification mangrove density performed landsat images folk time periods years identify spatiotemporal evolution sundarban mangrove infer causes observed changes specifically influences environmental anthropogenic drivers changes discriminated correlating observed change patterns cyclones tracks erosion processes areas expected human influences assessed local stakeholders results highlight dynamic systerh rapid changes characterized decreasing mangrove density mainly india erosion accretion similar net erosion years sundarban remains limited relative documented high rate sea level rise mangrove density changes attributed cyclones increased salinity anthropogenic influences based interpretation spatial pattern density changes local stakeholders conclude zones accessible human activities significantly affected land cover changes management policies sundarban bangladeshi indian authorities acknowledge important role played natural global drivers like sea level change cyclones affecting mangrove well manage localized anthropogenic pressures elsevier ltd rights reserved
recently flutter active control using linear parameter varying lpv framework attracted lot attention lpv control synthesis usually generates controllers least order aeroelastic models therefore reduced order model required synthesis avoidance large computation cost high order controller paper proposes new procedure generation accurate reduced order linear time invariant lti models using system identification flutter testing data proposed approach two steps well known poly reference least squares complex frequency lscf algorithm firstly employed modal parameter identification frequency response measurement parameter identification dominant physical modes determined clear stabilization diagrams clustering technique second step prior knowledge physical poles improved frequencydomain maximum likelihood estimator presented building accurate reduced order model estimation improved subspace identification considering poles constraint also proposed initializing iterative procedure finally performance proposed procedure validated real flight flutter test data chinese society aeronautics astronautics production hosting elsevier ltd open access article license
background patients liver cirrhosis higher risk cardiac surgery population based long term follow studies lacking aim study therefore validate long term outcome cardiac surgery patients methods results data obtained taiwan national health insurance database study included patients matched controls without actuarial survival rate years cohort significantly lower control cohort years cardiac surgery compared matched control cohort group higher risk liver heart failure readmission follow period addition cohort higher risk liver causes death control cohort cohort deaths due hepatocellular carcinoma group valve surgery advanced cirrhosis lower survival rate conclusions even successful cardiac surgery long term outcome unsatisfactory patients progressive deterioration liver function
ionic polymer metal composite ipmc kind ionic electroactive polymer eap smart material exhibit conspicuous deflection low external voltages similar cut various sizes shapes used applied robots artificial muscles capability aquatic operation ipmc strip modeled cantilever beam loading distribution surface nevertheless loading distribution non uniform due imperfect surface conductivity causes four different imaginary loading distributions employed structural model difference times paper novel linear time variant ltv model introduced applied model ipmc system modeling method different previous linear time invariant lti models internal environment ipmc may unsteady due mobile cations water molecules addition influence surface conductivity simulated proven based model finally applying novel modeling method hysteresis exists ipmc affects relationship output deflection corresponding input voltage rad sinusoidal waves shown simulated
analyses alternating electrical circuits electrical engineering usually based assumption currents voltages sinusoidal values assumption allows analysis electrical networks symbolic mathematical calculation also allows application vector diagrams representing relationship analyzed electrical values practice periodic non sinusoidal values sometimes found solving values symbolic mathematical calculation vector diagrams used paper shown non sinusoidal periodic values separated applying fourier series infinite series contains constant term infinitely many harmonic components way allows acquired knowledge methods solving sinusoidal periodic values still used
objective characterize compare cardiovascular disease cvd risk hiv infected uninfected postmenopausal minority women using framingham risk score frs assessment measure methods cross sectional analysis performed hiv hiv subjects existing study cohort postmenopausal hispanic african american women data necessary calculate frs menopause features retrieved retrospective chart review bivariate statistics used compare cvd risk factors multivariable linear regression used determine factors associated frs hiv infected women results hiv infected group younger less obese lower rates diabetes versus controls subset age matched participants median frs differ groups iqr iqr fourteen percent hiv infected women meeting criteria low risk frs category history cvd similar rate controls hiv infected women intermediate high cvd risk higher rates surgical menopause according clinical guidelines half hiv infected women prescribed statin therapy eligible treatment however statin therapywas similarly prescribed uninfected women conclusions study cvd risk assessed frs significantly different hiv status performance frs may compromised postmenopausal hiv infected minority women hiv infected uninfected women may undertreated statin therapy large longitudinal cohorts inclusion subclinical measures cvd necessary better characterize risk
analogue digital circuit thermal control resonance frequency optical ring resonators suggested approach characterised low power dissipation needs chip area cmos technology therefore well appropriate used control cells large optical switch matrices compared purely analogue heater control approach power dissipation reduced
myeloproliferative neoplasms mpn clonal disorders hematopoietic stem progenitor cells mutation janus kinase jak frequent genetic event detected philadelphia negative mpn advanced phases clinical hallmark disease striking inflammatory syndrome far cellular molecular basis inflammation fully understood therefore sought investigate relationship activating jak mutation aberrant cytokine expression mpn cytokine array performed identify jakvf related cytokine expression secretion cxcl mrna expression analyzed qpcr peripheral blood cells exclude paracrine autocrine stimulation potential mechanism generated epor jakwt epor jakvf cells lacking cxcl receptor pharmacologic inhibition jak kinase achieved jak inhibitor treatment signaling pathways downstream effectors characterized western blotting immunofluorescence microscopy luciferase reporter assays qpcr chromatin immunoprecipitation studies identified cxcl highly induced cytokine jak mutated cell lines mpn patients cxcl highly expressed jakvf jakwt mpn healthy donor controls moreover cxcl expression correlates jakvf allelic burden high cxcl correlates presence clinical risk factors clinical symptoms quality life pharmacologic inhibition mutated jak kinase inhibits cxcl expression kappa signaling activated downstream jakvf receptor directly induces cxcl expression data provide first evidence link oncogenic jakvf signaling cell intrinsic induction cxcl induced activated nfkb signaling
last decades tremendous rise number research studies dedicated towards development diagnostic tools based bio sensing technology early detection various diseases like cardiovascular diseases cvd many types cancer diabetes mellitus many infectious diseases many breakthroughs developed areas improving specificity selectivity repeatability biosensor devices innovations interdisciplinary areas like biotechnology genetics organic electronics nanotechnology also great positive impact growth bio sensing technology product improvements fast consistent sensing policies productively created precise ultrasensitive biomarker based disease diagnostics prostate specific antigen psa widely considered important biomarker used diagnosing prostate cancer many publications based various biosensors used psa detection limited review available classification biosensors used detection psa review highlights various biosensors used psa detection proposes novel classification psa biosensors based transducer type used also highlight advantages disadvantages limitations technique used psa biosensing make article complete reference tool future researches psa biosensing
since medieval times association religiosity anorexia nervosa suggested systematic studies exist study examines nationwide setting whether personal family religiosity associated lifetime anorexia nervosa among women adolescence early adulthood women birth cohorts finnish twins screened lifetime dsm anorexia nervosa parental religiosity assessed self report women aged years women self reported religiosity ages years parental religiosity increase risk lifetime anorexia nervosa neither religiosity women adolescence early adulthood shaped curve compatible data indicating increased risk low high levels religiosity result statistically non significant religiosity weakly negatively correlated body dissatisfaction suggestive evidence socioregional variation association religiosity lifetime anorexia nervosa first population study directly address religiosity anorexia nervosa evidence found significant association religiosity anorexia nervosa either personal family level regional differences possible modest protective association religiosity body dissatisfaction also possible despite compelling case descriptions holy anorexia religiosity appear central factor development anorexia nervosa finland highly secularized christian country
despite broad improvements construction management claims still inseparable part many construction projects due huge cases claim construction industry study argues claim management significant factor construction projects success study possible causes emerging claims identified statistically ranked probability impact matrix subsequently classifying claims different cases important ones ranked order achieve better understanding claim management project regard new index defined able applied variety projects different time cost values calculate amount possible claims project along related ratios respect cost time claim study introduces new model predict frequency claims construction projects using proposed model rate possible claims project obtained model validated applying fitting case studies iran construction industry
present article retrieves idea justice alain badiou aim contributing enunciate terms identify combat doctrinal morality underlying work performance basic education teachers concepts labour sociology lacanian psychoanalysis post foundational philosophy worked order reflect light reference overemphasis discipline bureaucracy basic education also served sustain argument applied idea alain badiou justice field formal school education requires fight prejudice programs regulations drawn experts automatically result improvement defend idea justice faithful disciplined action around equality dignity bodies ideas work teachers proposed first instance start training idea justice equality bodies ideas central contribution term quasipolitical understood act state inability crossing disappearing division labour experts simple executors
paper presents mixed reality system results integration telepresence system application improve collaborative space exploration system combines free viewpoint video immersive projection technology support nonverbal communication nvc including eye gaze interpersonal distance facial expression importantly features interpreted together people move around simulation maintaining natural social distance application simulation mars within collaborators must come agreement example rover land first contribution creation system supporting contextualization nvc two technological contributions prototyping technique subtract person background may contain physical objects moving images lightweight texturing method multiview rendering provides balance terms visual temporal quality practical contribution demonstration pragmatic approaches sharing space display systems distinct levels immersion research tool contribution system allows comparison conventional authored video based reconstructed avatars within environment encourages exploration social interaction aspects system quality including communication facial expression end end latency reported
transportation biofuel production efficiencies cruising ranges provided one hectare land studied life cycle perspective boreal climate zone efficient biofuel production essential terms sustainability especially land use biodiversity ghg emissions grass methane produced anaerobic digestion synthetic natural gas sng produced willows gasification provide longest cruising ranges however electricity production solar panels electric vehicles significantly efficient option biofuels grass methane straw ethanol sng require less primary energy per produced fuel energy options increasing biofuel production passenger cars cultivated biomass boreal climate zone carefully considered electricity transportation significantly efficient elsevier ltd rights reserved
organisational stressors associated positive negative outcomes extant literature however little known demands predict outcomes extant theory literature also suggests coping style may influence individual resilience vulnerability stressors subsequently psychological responses outcomes purpose study therefore examine main effects organisational stressors coping styles various outcomes positive negative affect performance satisfaction sport performers completed measures organisational stressors coping styles positive negative affect performance satisfaction multiple regression analyses revealed positive relationships goals development stressors duration intensity team culture stressors frequency intensity negative affect furthermore problem focused coping positively related positive affect emotion focused coping positively related negative affect study furthers theoretical knowledge regarding associations organisational stressors dimensions coping styles various outcomes practical understanding regarding optimal design stress management interventions
two dimensional boron nitride nanosheets rising material stars unique properties amazing functionalities concise history diverse synthesis routes nanosheets briefly summarized recent development towards mass production nanosheets chemical blowing technique relying blowing molten polymer precursors large polymeric bubbles subsequent annealing bubbles nanosheets focused abundant nanosheets enable applications especially representative polymeric composites nanosheet additives particularly highlighted review highly thermoconductive insulating filled composites thus envisaged high performance packaging materials electrical circuits
study numerically investigated laminar mixed convection heat transfer different water copper nanofluids inside microtube curvature angle degrees using finite volume method reynolds number modeling nanoparticles volume fractions chosen richardson numbers varied findings depicted dimensionless axial velocity coefficient friction nusselt number profiles well dimensionless temperature contours validity model excellent compared former numerical experimental studies results showed heat transfer hydraulics behavior nanofluids curved geometries extent different geometries flat surfaces due presence buoyancy centrifugal forces time especially regions near degrees curvature angle behavior heat transfer nanofluid flow unpredictable region increasing nanoparticles volume concentration transition forced convection regime free convection state cause decrease nusselt number friction factor entrance region microtube results completely opposite increasing richardson number nanoparticle concentration enhances heat transfer well friction factor also velocity profile variations vertical horizontal diameter microtube significant areas degrees heterogeneity profile increases rising rayleigh number volume fraction solid particles society powder technology japan published elsevier society powder technology japan rights reserved
network attacks cyber security breaches may cause huge monetary damages modern information based economy thus need network security stronger ever need full traffic sanitization nonetheless purge malicious packets still often relegated destination attacks letting unwanted traffic roam freely time next generation routers promises able modulate energy consumption basis actual traffic thus presence malicious traffic network cause economic losses even attack successful past work modelled analysed energy savings enabled aggressive intrusion detection however fluctuations traffic intensity fully taken account article introduce new enhanced adaptive model takes full account actual load routers including due forecasting errors
starting link discrete polynomial decomposition propose extension non uniform filter bank framework vector valued signals carry non marginal color wavelet transform recently quaternions clifford algebras used perform color image processing paper uses embedding color information imaginary part quaternion coding strategy discrete hypercomplex polynomial transform presented generalizing real polynomial transform hypercomplex domain illustrate numerical approach used define wavelet filter bank transform color image piecewise hypercomplex polynomial connection discrete polynomial representation multiscale filter bank algorithm already defined grayscale image described proposed color representation discussed new hypercomplex polynomial wavelet transform extra parameter imaginary unit quaternion corresponding privileged color direction new color representation satisfies conditions orthogonality perfect reconstruction linear phase filter moreover link hypercomplex polynomial projections discrete multiscale differentiators studied also give practical study new hypercomplex transform contexts image denoising validates interest construction
background arthroscopic meniscal repair limits medium term risk radiological osteoarthritis magnetic resonance imaging mri provide accurate assessment meniscal healing may show harbingers osteoarthritis meniscal extrusion objective study assess long term meniscal extrusion meniscal repair hypothesis arthroscopic meniscal suture followed meniscal extrusion therefore provide good knee function long term methods consecutive patients underwent arthroscopic meniscal suture stable stabilised knee included retrospectively mri performed measure absolute meniscal extrusion ame relative meniscal extrusion rme anterior sagittal extrusion ase posterior sagittal extrusion pse coronal cartilage coverage index ccci sagittal cartilage coverage index scci results mean follow years evidence meniscal extrusion patients stable stabilised knees ame rme ase pse ccci scci conclusion long term meniscal repair osteoarthritis limited meniscal function seems preserved elsevier masson sas rights reserved
efficient emission model radiation problems integrated circuits ics required early phase industrial design traditional source reconstruction methods rely exclusively near field scanning lack flexibility needed handle varying work conditions proposed hybrid model build physical connection inherent electric properties therefore simple parameter adjustments applied mode operation complete model consists two sets equivalent dipoles one converted directly current voltage information distributed along package initially solved linear equations describe relationship dipoles scanned fields multiplied scaling factor adapt varying work conditions emission behavior bit commercial microcontroller reasonably simulated full wave solver various working conditions proposed hybrid equivalent source model correctly predicted simulated reference fields operation mode feasibility flexibility proposed modeling method well validated
analyzed singular distributed parameter system sdps boundary conditions high dimension bounded domain sufficiently smooth boundary spectrum theory pde systems initially formulated infinite dimensional singular systems state space representation system built according matrices decomposition method admissible property discussed singular system theory novel uniform state feedback controller designed
objectives assessed ability patients autoimmune inflammatory diseases successfully use investigational autotouch reusable autoinjector well patient preference autotouch versus currently marketed single use prefilled etanercept sureclick autoinjector methods two multicenter studies performed home use study patient preference study home use study patients rheumatoid arthritis psoriatic arthritis self administered etanercept weekly weeks primary end point successful self injection etanercept via autotouch patient preference study open label randomized week crossover trial weeks device patients psoriasis pso primary end point preference autotouch versus sureclick results home use study proportion successful self injections autotouch weeks patient preference study patients preference rate autotouch overall patients patients pso needle apprehension different initiation autoinjectors difference injectors weeks overall patients preferred autotouch ease self injecting ease pressing start button ease following injection progress certainty knowing injection completed sureclick preferred fewer steps experiencing less injection site discomfort pain conclusion introduction autotouch give patients choice two different autoinjectors self administration etanercept
paper deals design load test outer rotor permanent magnet synchronous generator pmsg purpose many analyses made identify modification geometrical parameters help improve voltage waveform winding terminals generator tests results complements previous works presented analysis pmsg total harmonic distortion thd analyzed design parameters handling geometry stator polar arc percentage air gap skew angle rotor poles pole length core steel class seventy six cases simulated results provide useful information designing machines tests machine help verify electromagnetic analysis finally important stages generator building process shown
increasing concern serious global energy crisis high energy consumption high content solid wastes hcsws treatment microbial fuel cell mfc recognized promising resource utilization approach hcsw stabilization simultaneous electrical energy recovery contrast conventional hcsw stabilization processes mfc unique advantages direct bio energy conversion single step mild reaction conditions viz ambient temperature normal pressure neutral review mainly introduces important aspects electricity generation hcsw stabilization mfc focusing mfcs different fundamentals configurations designed constructed produce electricity hcsw performance wastes degradation electricity generation prospect deficiency posed mfcs hcsw substrates date major drawback mfcs fueled hcsw lower power output using simple substrates hcsw hydrolysis decomposition would major tool improve performance mfcs optimization parameters needed push progress mfcs hcsw fuel higher education press springer verlag berlin heidelberg
systematic review meta analysis investigate clinically relevant effects selenium supplementation patients chronic autoimmune thyroiditis controlled trials adults years autoimmune thyroiditis comparing selenium without levothyroxine substitution versus placebo levothyroxine substitution eligible inclusion identified outcomes serum thyrotropin thyroid stimulating hormone levels untreated patients thyroid ultrasound health related quality life eleven publications covering nine controlled trials included systematic review random effects model meta analyses performed weighted mean difference thyroid stimulating hormone ultrasound health related quality life quality evidence assessed per outcome using grade meta analyses showed change thyroid stimulating hormone improvements health related quality life thyroid echogenicity ultrasound levothyroxine substitution untreated patients assigned selenium supplementation placebo three trials found improvement wellbeing patients receiving levothyroxine substitution could synthesized meta analysis quality evidence ranged low low thyroid stimulating hormone well ultrasound outcomes low moderate health related quality life generally downgraded due small sample sizes found effect selenium supplementation thyroid stimulating hormone health related quality life thyroid ultrasound levothyroxine substitution untreated individuals sporadic evaluation clinically relevant outcomes levothyroxine substitution treated patients future well powered rcts evaluating disease progression health related quality life warranted determining relevance selenium supplementation autoimmune thyroiditis
article investigates evolution data quality issues traditional structured data managed relational databases big data particular paper examines nature relationship data quality several research coordinates relevant big data variety data types data sources application domains focusing maps semi structured texts linked open data sensor sensor networks official statistics consequently set structural characteristics identified systematization posteriori correlation quality dimensions provided finally big data quality issues considered conceptual framework suitable map evolution quality paradigm according three core coordinates significant context big data phenomenon data type considered source data application domain thus framework allows ascertaining relevant changes data quality emerging big data phenomenon integrative theoretical literature review
robots seemingly possession experiential mind well humans allegedly incapable thereof reported elicit feelings eeriness perceivers current work examined claim asking participants rate robots humans various social situations regarding mind capacities emotional capability intelligence non mind qualities animacy usefulness overall appeal eeriness likeability found feelings eeriness towards targets formed distinct emotional response separable simple dislike yet unexpectedly eeriness towards targets intensified less seen possessing typical human mind robots however association less consistent moreover eeriness towards robots towards humans strongly predicted lack perceived usefulness results indicate mind attributions affect people attitudes towards strongly attitudes towards humanoid robots
system nonlinear parabolic equations describing evolution color image considered existence uniqueness global solution mixed problem system proved
flood modeling forecasting using hydraulic models computationally expensive high resolution large scale problems advent high performance computing numerical models obtain promising speedup using parallel computing resources paper message passing interface mpi based parallel shallow water flow solver using discontinuous galerkin method presented parallelization implemented static domain decomposition using single program multiple data design data transfer subdomains achieved using mpi implementation parallel solver tested using idealized dam break tests field tests fully wet partially wet domains performance parallel speedup efficiency compared different mesh resolution cluster architecture statistical index maximum ratio halo cells total number elements introduced evaluate parallel efficiency performance index used guide choose number cores applications american society civil engineers
aim study investigate consequences exposure three levels boric acid male rats reproduction fertility progeny outcome emphasis testicular dna level quality adult male rats weeks old treated orally bwt results indicated administration bwt adverse effects fertility sperm characteristics prenatal development impregnated females however dose treatment significantly increased serum nitric oxide testosterone estradiol levels testicular boron calcium levels also significantly reduced serum arginase activity sperm quality testicular dna content minor dna fragmentation impact exposure dose male rats fertility translated increases pre implantation loss resulting decrease number live fetuses litter addition significant alteration biochemical measurements observed dose administration caused testicular atrophy severe damage spermatogenesis spermiation failure significant reduction testicular levels none male rats treated bwt could impregnate untreated females suggesting occurrence definitive loss fertility conclusion impaired fertility dose dependant manner targeting highly proliferative cells germ cells decreasing dna synthetic rate rather induction dna damage
several studies showed efficiency natural techniques dewater sludge water treatment plants brazil objective study evaluate dewatering system drainage drying geotextile blanket using sludge decanters two types water treatment plants laboratory experiments reduced scale following technical parameters project considered density blanket application rate solids volumetric application rate drying different climate conditions drainage phase total volume percolated liquid presented compatible quality standardized limits freshwater bodies classes according resolution national council environment drying phase possible obtain total solid rates values magnitude order obtained mechanical drainages even critical drying conditions
paper examine use performance based financing scale hiv testing men sex men msm global health initiatives china mechanism ties financing directly achievement targets indicators assures measurable results produced health interventions accounts financial spending one hand adoption hiv programming china articulates broader shifts global health place currency particular forms evidence time performance based financing reshapes hiv interventions carried counts programmes suturing financing outputs directs gets counted consequence leads production measurable results end based months ethnographic research carried china explore effects mechanism ask gets left pursuit evidence particular demonstrate demand outputs undermines hiv prevention msm thus risking lives interventions intended save
hear event description mental construal based lexical items also message syntactic structure well studied domains causation event participants object conceptualization less studied construals temporality numerosity function syntax present theory syntax affects construal event similarity duration way systematically predictable interaction mass count syntax verb semantics test predictions six studies punctive events count syntax give kiss durative events mass syntax give advice construed taking less time transitive frame kiss advise durative verbs count syntax give talk however result semantic shift orthogonal duration estimates results demonstrate syntactic semantic structure together systematically affect event construal author published elsevier inc
purpose main purpose review critically evaluate literature psychotherapies borderline personality disorder bpd published past years identify progress remaining challenges determine priority areas future research method systematic review literature last years undertaken results review yielded relevant abstracts applying inclusion criteria articles fully reviewed based articles implications future research clinical practice conclusion review indicated patients various severities benefited psychotherapy intensive therapies significantly superior less intensive therapies enhancing emotion regulation processes fostering coherent self identity important mechanisms change therapies extended patients bpd posttraumatic stress disorder research needed directed functional outcomes
objective evaluate micro rna mirna expression profile patients early psoriatic arthritis psa order assess role mirnas potential psa biomarkers methods expression mature mirnas peripheral blood mononuclear cells early psa patients comparison early rheumatoid arthritis era patients healthy controls evaluated using mirna microarray patients active disease treatment results validated specific mirna mir entire series patients plus additional group early psa era using droplet digital pcr results psa microarray analysis revealed distinct pattern era deregulated mirnas significant regulation mir early psa era comparison validated confirmed psa mir found significantly regulated weeks therapy significantly correlated reduction dapsa score conclusion early psa era mirna signature identified differential expression mirnas patients active disease makes attractive biomarkers psoriatic disease mir found regulated early psa era finding highlights role inflammatory process general potential role therapeutic target different inflammatory disorders potential role mir response treatment biomarker early psa identified
time series utilized geodetic signal analysis strain groundwater level data usually largely affected barometric pressure earth tide precipitation also suffer missing observations due instrument maintenance breakdown detect informative geodetic signal heavily noise affected data one must build time series model decomposition data taking account characteristics effects covariates paper proposes new modeling method detecting geodetic signal earthquake related time series data introducing pole restricted precipitation model jump component pre processing model interpolating missing observations using proposed method geodetic sample data decomposed stably several components including geodetic trend signal barometric pressure response earth tidal response precipitation response data level shift due mechanical maintenance breakdown decomposition time series interpolation missing observations performed efficiently using state space representation kalman filter smoother finally case studies real geodetic sample data demonstrate effectiveness proposed modeling method lead important findings seismology elsevier inc rights reserved
paper presents novel multi channel optical filter structure proposed design based using set microring resonators mrrs new formation named flower like arrangement shown instead using mrrs using mrrs recommended formation filtering operation achieved shown structure six filters four integrated demultiplexers demuxs obtained simplicity extensibility compactness structure make usable wavelength division multiplexing wdm networks filter characteristics shape factor free spectral range fsr stopband rejection ratio designed adjusting microrings radii coupling coefficients model structure signal flow graph method sfg based mason rule used modeling method discussed depth furthermore accuracy applicability method verified examples comparison modeling schemes elsevier rights reserved
background capacity emotion recognition understanding crucial daily social functioning examined extent capacity impaired young children language impairment typical development children learn recognize emotions faces situations social experiences social learning children less access experiences therefore expected fall behind peers without method study preschool children children without mean age years months groups tested three indices facial emotion recognition discrimination identification attribution emotion evoking situations parents reported children emotion vocabulary ability talk emotions results preschoolers without performed similarly non verbal task emotion discrimination children fell behind peers without tasks emotion recognition involved labelling four basic emotions happy sad angry fear outcomes two tasks also related children level emotion language implications outcomes emphasize importance emotion talk youngest age possible children elsevier ltd rights reserved
background aims despite decades research occurring smoking depression cessation rates remain consistently lower depressed smokers smokers general population highlighting need theory driven models smoking depression paper provides systematic review particular focus upon psychological states disproportionately motivate smoking depression frame incentive learning theory account smoking depression occurrence methods searched pubmed scopus psychinfo cinahl december yielded papers using pre established eligibility criteria identified papers focused clinical issues motivational mechanisms underlying smoking established adult smokers maintenance quit attempts cessation relapse elevated symptoms depression two reviewers determined independently whether papers met review criteria included papers qualitative synthesis results review identified three primary mechanisms underlie persistent smoking among depressed smokers low positive affect high negative affect cognitive impairment propose novel application incentive learning theory posits depressed smokers experience greater increases expected value smoking face three motivational states promotes goal directed choice smoking behavior alternative actions conclusions incentive learning theory accounts current evidence depression primes smoking behavior provides unique framework conceptualizing psychological mechanisms smoking maintenance among depressed smokers treatment focus upon correcting adverse internal states beliefs high value smoking states improve cessation outcomes depressed smokers
budding lentiviral particles lvp incorporate cell membrane proteins viral envelope explored possibility harnessing process generate lvp expressing membrane proteins therapeutic interest studied potential tools treat different pathologies fas mediated apoptosis central maintenance cell homeostasis prevention autoimmune processes prepared lvp express murine fasl surface data indicate mfasl bearing lvp induce caspase processing cytochrome release significantly cell death control lvp vitro cytotoxicity blocked caspase inhibitor vad analysis application reagents treatment inflammatory arthritis vivo suggests fasl expressing lvp could useful therapy autoimmune diseases rheumatoid arthritis excess fas expressing activated cells joint lvp could vehicle mfasl also membrane bound proteins maintain native conformation might mediate biological activities
identifying flow processes multi aquifer flow systems considerable challenge especially substantial abstraction occurs rajshahi barind groundwater flow system bangladesh provides example manner flow processes change time locations decrease time groundwater heads also magnitude seasonal fluctuations report describes important stages detailed field modelling study specific location groundwater flow system understand changing conditions piezometers constructed different depths location water levels piezometers indicate formation additional water table conceptual models described show conditions changed years following formation additional water table aquifer system conceptualised two units pumping test described data collected pumping recovery phases pumping test data lower unit analysed using computational model estimates aquifer parameters model also provided estimates quantity water moving ground surface upper unit provide input lower unit reasons substantial changes groundwater heads identified monitoring recently formed additional water table provides means testing whether abstraction occurring
construction safety important domains architecture engineering construction however studies rarely discussed safety issues perspectives employers employees ignorance safety requirements novel approach modeling reasoning functionalities applied semi automated identification safety requirements construction safety standards proposed approach based ontological modeling document modeling techniques techniques model safety concepts requirements semantically rich human readable computer interpretable format features enable reasoning concepts requirements needed identify applicable safety requirements test cases used validate approach illustrate advantages validation results discussed conclusions directions future research given proposed approach benefit construction safety improving participants awareness safety requirements
physical education syllabuses promoting life skills constitutes important educational objective aim study implement coping training program ephect within regular evaluate effects coping stress among vocational students eight classes vocational school selected study four allocated intervention group four control group study examined intervention effects pre postintervention postintervention months follow compared showed improved coping skills pre postintervention postintervention follow stress decreased path analysis suggests indirect effect stress perception follow via improved adaptive coping skills findings support ephect positive contribution development adaptive coping skills project shows physical educators translate psychological theory practice
objectives dental personnel risk develop asthmatic disease exact reason far unknown abrasive procedures dental personnel exposed nano sized dust particles released dental composite aim study investigate whether respirable composite dust may also release monomers methods respirable composite dust collected release methacrylate monomers bisphenol bpa water ethanol evaluated liquid chromatography mass spectroscopy dust ultra morphologically chemically analyzed transmission electron microscopy energy dispersive ray spectroscopy tem eds results analysis revealed irrespective type composite respirable fraction composite dust may release relatively high concentrations unpolymerized methacrylate monomers water ethanol higher release observed ethanol endocrine disruptor bpa also emanated composite dust particles tem showed particles nano sized although particle size ranged mode value particles consisted several filler particles resin matrix although single nano filler particles could also observed elemental analysis tem eds proved particles collected filters originated dental composites conclusion theoretically composite dust may function vehicle transport monomers deeply respiratory system results study may shed another light increasing incidence respiratory disease among dental personnel care taken prevent inhalation composite dust clinical significance special care taken prevent inhalation composite dust dust particles may release methacrylate monomers elsevier ltd rights reserved
shelf moisture responsive acetate backed adhesive tape investigated commercially available smart material fabricating low cost multifunctional humidity responsive millimeter scale structures laser ablation used cutting thinning tape enhance response water submerged cantilevers show radius curvature lower laser thinned cantilevers additionally humidity response function angle longitudinal axis cantilever polymer orientation cut angled degrees respect orientation results tip rotation degrees enabling formation bending cantilevers twisting behavior tape cantilevers functionalized magnetic nanoparticles used create four finger grippers close underwater within minutes sample liquid cyclic humidity monitor also fabricated using tape strip walks unidirectionally ratchet shaped surface upon exposure humidity variations wiley periodicals inc
objective investigate whether bright light treatment reduce body mass overweight subjects irrespective seasonal light dependence methods crossover placebo controlled randomized clinical trial performed november april novosibirsk russia degrees trial comprised week home session morning bright light treatment using device light emitting diodes week placebo session means deactivated ion generator separated protocol period least days number placebo light sessions matched respect season data obtained overweight women aged years seasonal dependent according seasonal pattern assessment questionnaire weekly measures included body weight percentage body fat bioimpedancemetry subjective scores appetite mood energy levels results motivation expectation towards weight loss similar two intervention sessions light compared placebo session weight reduce significantly percentage fat fat mass appetite significantly lower average fat reduction latter two results remained significant excluding seasonal dependent subjects analysis irrespective type intervention seasonal dependent subjects greater weight fat mass changes treatment decline sessions regain photoperiod air temperature lesser extent sunshine associated weight change greater weight reduction second session spring conclusion morning bright light treatment reduces body fat appetite overweight women may included weight control programs copyright karger gmbh freiburg
paper introduces fast algorithm randomized computation low rank dynamic mode decomposition dmd matrix consider matrix represent development spatial grid time data static video source dmd originally introduced fluid mechanics community also suitable motion detection video streams use background subtraction received little previous investigation study present comprehensive evaluation background subtraction using randomized dmd compare results leading robust principal component analysis algorithms results convincing show random dmd efficient powerful approach background modeling allowing processing high resolution videos real time supplementary materials include implementations algorithms python elsevier inc rights reserved
paper presents alternative existing techniques based nodal analysis designed specifically suit implementation matrix oriented programming languages keeping simplicity original nodal analysis bringing improvements make virtually circuit topologies solvable dealing potential singularities hence name singular nodal analysis sna two variants novel algorithm described validity proven applicability shown two practical examples
aim study perform systematic review etiology nasal bone fractures nbfs pubmed titles scopus search terms nasal bone fracture etiology cause used among titles duplicated excluded titles excluded abstracts read subsequently abstracts excluded full articles providing data etiologies nbfs reviewed finally papers incorporated analysis causes nbfs different adults children adults frequent causes fights traffic accidents sports falls children frequent causes sports fights traffic accidents collisions falls noticeable fights traffic accidents falls frequent adults children although sports collisions frequent children adults causes nbfs varied geographically fights frequent cause asia south america europe north america however traffic accidents frequent cause followed fights sports among sports injuries ball related sports frequent cause fighting related sports contributed relatively small proportion nbfs efforts prevent nbfs children sports injuries primarily considered restraining devices seatbelts needed prevent nbfs caused traffic accidents especially north america
increasing networking performances well emergence mixed reality technologies make possible providing advanced interfaces improve remote collaboration paper present novel interaction paradigm called vishnu aims ease collaborative remote guiding focus collaborative remote maintenance illustrative use case relies expert immersed virtual reality remote workspace local agent helped augmented reality interface main idea vishnu paradigm provide local agent two additional virtual arms controlled remote expert use interactive guidance tools many challenges come collocation inverse kinematics perception remote collaborator gestures coordination vishnu aims enhance maintenance procedure thanks remote expert show local agent exact gestures actions perform pilot user study shows may decrease cognitive load compared usual approach based mapping localized informations could used agents order perform specific procedures without needing available local expert
according fluid mechanics rolling theory rolling interface friction dynamic characteristics influence rolling speed rolling load roller material rolling temperature oil properties studied respectively lubrication without lubrication hot rolling two dimensional reynolds equation established steady unsteady rolling friction interface research rolling interface friction characteristics influence mill vibration found lubrication film thickness roll gap thicker friction coefficient lower damping effect system stability worse rolling speed greater certain value rolling interface friction coefficient fall sharply increase rolling speed produces self excited vibration caused negative damping contrast test different rolling interface carried emulsion open close high chromium cast iron high speed steel roller put use high chromium cast iron roller grinded finely coarsely rolling speed normal reduced results showed obvious effect mill vibration suppression adoption emulsion close high speed steel roller
article address cyber technology may facilitate reflective functioning patients present primitive self states fragmentation dissociation utilization text based information communication technology may allow reflective space apart therapist explicit intrusion potential danger abandonment rejection may help develop capacity reflection symbolization case illustration research findings discuss benefits challenges using cyber technology adjunct face face treatment
article propose method generating two dimensional schematic diagrams three dimensional models mechanical electrical plumbing systems computer aided design software represent information traditional user friendly format difficult grasp relationships various mechanical electrical plumbing elements building information models represented visually complex three dimensional manner hand relationships building elements easily understood using traditional schematic diagrams first network mechanical electrical plumbing systems section view extracted separately three dimensional models next extracted files displayed schematic diagrams computer aided design software expressions traditional drawings referenced generate new diagrams schematic diagrams created evaluated staff members facilities department university japan
study aimed explore different pathogeneses combined pulmonary fibrosis emphysema cpfe emphysema pulmonary fibrosis levels transforming growth factor beta tgf beta vascular endothelial growth factor vegf krebs von den lungen matrix metalloproteinase mmp tissue inhibitors metalloproteinases timp cytokeratin fragment cyfra squamous cell carcinoma antigen scc telomerase activity peripheral blood measured cpfe patients pulmonary emphysema patients idiopathic pulmonary fibrosis ipf patients results demonstrated levels vegf tgf beta ipf patients significantly higher emphysema patients levels cyfra ipf patients significantly higher emphysema cpfe patients among three groups levels scc mmp timp mmp timp ratio telomerase activity different study showed vegf tgf beta cyfra may play role pathogenesis pulmonary fibrosis lower levels cyfra cpfe patients may one reasons patients develop emphysema basis fibrosis
aggressive behaviors schools potential cause serious harm students emotional social well limit ability achieve full academic potential prevention programs developed reduce children aggressive behaviors school settings provide interventions universal targeted level main aim randomized control study examine efficacy coping power adapted universal prevention program reducing children behavioral problems improving school grades nine classes participated students mean age months two elementary state schools tuscany italy study findings showed significant reduction behavioral problems improvement school grades intervention classes relative control classes study suggests coping power program delivered school settings universal targeted prevention levels multi tiered prevention model teachers educators school psychologists learn set intervention skills delivered flexibility thus reducing complexity costs schools using multiple interventions
despite knowledge cellular molecular mechanisms involved myeloproliferative neoplasm mpn pathophysiology remain unclear authors shown galectin gal playing roles tumour angiogenesis fibrosis correlated poor prognosis patients mpn present study lgals lgals differently expressed polycythemia vera essential thrombocythemia primary myelofibrosis pmf diseases increased lgals expression associated negative jak status mutation leucocytes pmf patients without mutation however positive janus kinase jak cell line established patients set cells treated jak inhibitor presented high levels lgals additionally high lgals expression found cells leucocytes patients pmf absence jak mutation also set cells treated jak inhibitor thus findings indicate differential expression lgals lgals patients mpn linked jak status mutation diseases state cell differentiation
acoustophoresis ability acoustically manipulate particles cells inside microfluidic channel critical enabling technology cell sorting applications however one major impediments routine use acoustophoresis clinical laboratory reliance inherent physical properties cells separation present microfluidic based microbubble activated acoustic cell sorting baacs method rely specific binding target cells microbubbles conjugated specific antibodies surface continuous cell separation using ultrasonic standing wave acoustophoresis cells positive acoustic contrast particles migrate pressure nodes contrary air filled polymer shelled microbubbles strong negative acoustic contrast particles migrate pressure antinodes used selectively migrate target cells proof principle demonstrate separation cancer cell line suspension better efficiency moreover microbubble cell conjugates migrated anti node hence better upstream affinity capture potential provide higher sorting efficiency baacs technique expands acoustic cell manipulation possibilities offers cell sorting solutions suited applications point care
inspired progresses cognitive science artificial intelligence computer vision mobile computing technologies propose implement wearable virtual usher cognitive indoor navigation based egocentric visual perception novel computational framework cognitive wayfinding indoor environment proposed contains context model route model process model hierarchical structure proposed represent cognitive context knowledge indoor scenes given start position destination bayesian network model proposed represent navigation route derived context model novel dynamic bayesian network dbn model proposed accommodate dynamic process navigation based real time first person view visual input involves multiple asynchronous temporal dependencies adapt large variations travel time trip segments propose online adaptation algorithm dbn model leading self adaptive dbn prototype system built tested technical performance user experience quantitative evaluation shows method achieves improvement accuracy compared baseline approaches based hidden markov model user study system guides participants destinations emulating human usher multiple aspects
order promote development green building market without bringing heavy financial burden government paper studies optimal subsidy problem green building market perspective policy benefit government end user principals developer agent optimal subsidy principal agent models conditions asymmetric information complete information established equivalent models presented get optimal solutions results show perspective policy benefits subsidy policy influenced construction costs transfer paid end user developer preference toward green buildings furthermore comparisons models two conditions demonstrate eliminating asymmetric information contribute green building areas fewer unit subsidies finally numerical example presented show effectiveness model
discuss energy density temperature entropy dark matter dark energy functions scale factor expanding universe model non interacting dark components repeat derivation thermodynamics well known relations energy density entropy temperature particular entropy constant consequence energy conservation consider model interaction energy density increase proportional particle density model dependence energy density temperature scale factor substantially modified discuss realization model consists relativistic particles diffusing environment energy gained dark matter comes cosmological fluid negative pressure define entropy free energy non equilibrium system show universe evolution entropy increasing whereas entropy decreasing total entropy increase spite energy conservation temperatures different discuss non equilibrium thermodynamics basis notion relative entropy
objective assess effects week stress management health promotion program women undergoing breast cancer chemotherapy treatment patients methods total patients recruited cancer centers randomly assigned intervention program control group intervention program consisted different stress management techniques combined instructions lifestyle modification assessments carried questionnaires measurement body mass index bmi baseline end week program results participants completed intervention program whereas participants completed observational control program intervention program resulted small effect size internal dimension health locus control hlc medium effect size stress depression anxiety night sleep duration chance dimension hlc strong effect size recorded bmi sleep onset latency self rated health spiritual well powerful others dimension hlc significantly affected additionally participants reported reduction side effects caused chemotherapy conclusions intervention resulted several benefits general health status patients therefore considered feasible potentially beneficial women undergoing breast cancer chemotherapy however necessary intervention tested randomized controlled trial larger sample patients adopting program standard cancer care
research threat documents negative consequences similarly research intergroup contexts emphasized negative behavioral effects drawing meaning maintenance model recent perspectives potential positivity intergroup conflict predicted meaning threat produce antisocial prosocial responses intergroup conflict depending people preexisting meaning frameworks studies demonstrated meaning threat low ingroup glorifiers strengthened support peaceful conflict resolution whereas high ingroup glorifiers strengthened support military based conflict resolution context israel palestinian conflict study found low glorification associated greater support peace hot cold conflict hot conflict reduced meaning life findings consistent notion meaning threatened people affirm preexisting values whether prosocial antisocial even context intergroup conflict
describe quantitative model heat separation fluid due motion along pressure gradient physical model involved relevant one explanation temperature separation vortex tube effect point saturation fluid temperature pressure related boundaries adiabatic law vortex tube models sometimes assume saturation achieved physical devices conclude likely safe assumption much time describe circumstances saturation might achieved propose test model temperature separation elsevier ltd rights reserved
tremendous growth internet large amounts data generated create big challenges nowadays computing technologies systems however hand also sheds new light areas data analytics mining enables uncovering patterns laws beneath big data recent years big data analytics successfully applied many areas commerce healthcare industry time security analytics based big data also receive great attention academic industry paper give comprehensive sketch techniques applications big data network security analytics existing research works classified three types supervised unsupervised hybrid approaches elaborate technical issues three kinds approaches compare advantages disadvantages finally outlook potentials research directions future
morphological characteristics infant face collectively referred baby schema babyishness well established infant traits implicitly projected overgeneralized adults babyish facial features however studies date investigated neural underpinnings generalization present study addressed issue comparing neural activations elicited baby faced mature faced adult faces men using fmri found increased activations clusters surrounding bilateral insula bilateral anterior cingulate cortex right inferior frontal gyrus previously linked processing facial attractiveness infant related information also discovered increased activation left medial prefrontal cortex might related emotional empathic responses directed towards baby faced adults activated region also included left premotor cortex presumably reflects embodied response approach motivation directed toward infant related information furthermore activation level left caudate correlated salivary concentration oxytocin taken together findings indicate passive viewing babyish adult faces induces increased responses neural regions linked facial attractiveness infant related information processing responses partially influenced oxytocinergic factors
purpose analysed hyaline cartilage human knee ankle joints collagen proteoglycan turnover order find differences metabolism biochemical content extracellular matrix could explain higher prevalence osteoarthritis knee joint compared ankle joint methods cartilage tissue ankle knee joints patients assessed total collagen proteoglycan content turnover aggrecan epitope type collagen propeptide collagenase generated intrahelical cleavage neoepitope quantified results molecular analyses showed type collagen turnover significantly elevated ankle whereas aggrecan turnover total proteoglycan total collagen comparable joints analysis inter relationships components cartilage matrix turnover showed significant positive correlation conclusions data suggest increased type collagen turnover ankle knee cartilage comparable aggrecan turnover comparable contents type collagen proteoglycan findings point towards focused attempt advanced cartilage structurally repair collagen network pronounced ankle joint may explain part higher prevalence knee compared ankle joint
architecture implemented software system parsing schemes algebraic algebra interpretation software system allows generate automated schemes create program debug relevant schemes clear division algebraic algebra separate modules defined characterized functional load methods parsing development presentation grammar schemes used automatic transforming list form implemented machine system algebraic algebra abstract interpretation mechanism grammar parser defined vocabulary consists finite empty set lexical units expression finite length string lexical units empty string contain lexical items denoted set lexical units denoted language subset language displayed set lexical units language definition criteria satisfy lexical items belong language another one important method set language use generative grammar grammar consists lexical units set various types rules productions set expression constructing grammar vocabulary set lexical units language expressions building lexical units vocabulary terminal replaced lexical units text realizes structural submitted activities provides subject object process purpose means results appear content structural functional communicative criteria parameters units internal organization text structure alphabet vocabulary paradigmatics grammar syntagmatic paradigm paradigmatic relations syntagmatic relation identification rules expressions unity phrasal fragments blocks compositional level isolated sentences paragraphs sections chapters chapter page etc except sentence indirectly related internal structure considered help database database terms morphemes structural parts speech defined rules text analysis searching terms parsers operate two stages lexemes content identifying parsing tree creates
structural molecular properties antidepressants dimethylamino propyi fluorophenyl dihydroisobenzofuran carbonitrile examined using quantum mechanics density functional theory dft blyp pbepbe methods lanldz basis sets study therapeutic properties drug structure desired material optimized computer calculation method use powerful gaussian software lowest energy value bond length bond angle dihedral angle constituent atoms crystal structure desired material measured optimized values amount positive negative charges polarizability dipole moment atoms using mulliken charge natural atomic charges dft blyp pbepbe methods lanldz basis sets determined results compared individual atoms mentioned methods also type stretching vibrations bending vibrations constituent atoms molecule specified using mentioned computational methods vibrational spectra experimental spectrum material taken determine functional groups computational experimental values compared nuclear magnetic resonance nmr used specify isomer shift carbons protons presence polar non polar solvents also natural bond orbital nbo used determine type electron transfers sigma sigma sigma sigma amount hardness softness molecule determined using difference ionization energy electron affinity energy constituent atoms molecule highest occupied molecular orbital homo lowest unoccupied molecular orbital lumo presence solvents chcn vis spectrum drug taken using dft blyp pbepbe methods lanldz basis sets well solvents chcn associated transmissions examined elsevier rights reserved
self report inventories enable efficient assessment mental attributes large representative surveys however inventory administered several ways whose equivalence largely untested present study administered thirteen psychological questionnaires assessing positive negative aspects mental health questionnaires administered four different data collection methods face face interview telephone interview online questionnaire offline questionnaire found twelve questionnaires differed survey methods although studies showed social desirability tends highest telephone survey lowest web survey furthermore effects social desirability online offline samples however statistically significant differences face face telephone samples anxiety scale stress scale tradition scale also found eight scales online sample statistically different offline sample respondent answers moreover survey method effects moderated age finally measurement invariance across four survey methods tested self report measure full strong measurement invariance established nine thirteen scales partial strong measurement invariance remaining four scales across four survey methods findings indicated measurement invariance affected different survey methods elsevier ltd rights reserved
paper reviews characteristics smart materials piezoelectrics pzt shape memory alloys sma mganetostrictive materials terfenol since properties smart materials vary greatly terms free strain actuation stress need identify optimum smart materials particular application review comparison different types pumps based pzt sma terfenol recognize pumps unique advantages specific application fields
aim variations sex hormone levels menstrual cycle may affect neuromuscular performance risk sustaining musculoskeletal injury women aim study investigate mrna protein levels sex steroid hormone receptors skeletal muscle three distinct phases menstrual cycle methods fifteen healthy women regular menstrual cycles participated study muscle biopsies vastus lateralis obtained three hormonally verified phases menstrual cycle individual follicular phase ovulatory phase luteal phase mrna protein levels oestrogen progesterone androgen receptors analysed results overall significant variation mrna protein levels across menstrual cycle mrna protein levels highest follicular phase oestradiol levels low whereas protein levels highest luteal phase progesterone levels high mrna levels highest ovulatory phase significant variation levels detected across menstrual cycle levels low three phases menstrual cycle conclusion significant variations mrna protein levels detected skeletal muscle three confirmed phases menstrual cycle results may impact effects muscular training sports injuries women
smart meters play vital roles aspects management operation smart grids demand response energy efficiency improvement electricity pricing massive amounts data collected owing popularity smart meters two main issues addressed context one communication storage big data smart meters reduced cost effective extraction useful information massive dataset paper svd sparse representation technique includes two phases dictionary learning sparse coding used decompose load profiles linear combinations several partial usage patterns pups allows smart meter data compressed hidden electricity consumption patterns extracted linear support vector machine svm based method used classify load profiles two groups residential customers small medium sized enterprises smes based extracted patterns comprehensive comparisons results means clustering discrete wavelet transform dwt principal component analysis pca piecewise aggregate approximation paa conducted real datasets ireland results show proposed technique outperforms methods compression ratio classification accuracy
using mixed methods approach researcher gathered set narrative responses focus groups supported claim underreporting campus discrimination survey multiple studies shown underrepresented minority students likely bond ethnic peers racially tense campus climate mixed method follow investigation post environment arab muslim american community college students demonstrated less variation level perceived discrimination relationship percentage ethnic faith campus friendship groups post hoc comparisons revealed arab muslim students exhibited significantly higher mean scores perceived discrimination scale ethnic groups
aim paper present specific context occurrence sexual problems sexual dysfunction population homo bisexual men sexual problems revealing usually big challenge men case homo bisexual men additional psychological social factors may contribute occurrence problems well make experiencing painful also impede looking receiving adequate help factors connected specific features gay men sexuality lack obvious sexual scripts homosexual men full reversibility sexual roles positions contacts two men fear unwanted pregnancy also unique psychosocial context minority stress internalized homophobia clinicians psychiatrists sexologists psychologists aware existence deliver effective professional culturally competent care free prejudice based deepened reflection void automatic transference experiences work heterosexual men slowa klucze dysfunkcje seksualne homoseksualnosc
background coccidioidomycosis potentially fatal fungal infection considered emergent mycotic disease increased incidence fungal infections registered recent years infection occurs inhalation arthroconidia two main species coccidioides coccidioides immitis posadasii endemic arid semi arid regions north america coccidioides species infect humans also infect mammals land aquatic wild domestic reptiles birds objective obtain information regarding habitat coccidioides spp animals infected fungus identify role infected animals play reservoirs disseminators fungus nature materials literature review conducted identify habitat coccidioides spp infected non human animal species targeted fungus results conclusions review allows suggest coccidioides spp may classified halotolerant organisms nevertheless perpetuate life cycle organisms depend different animal species reservoirs serve link environment acting disseminators fungi nature
new approach constructing adsorption thermodynamics provides derivation rigorous thermodynamic relationships adsorption system particularly system deformable adsorbent proposed expressions thermodynamic functions adsorption system form arbitrary control volume containing adsorbent adsorbed gas derived derived expressions role adsorption played total adsorbate content system control volume boundaries set appropriately quantity identical absolute adsorption
transport sector electric vehicles evs widely accepted next technology paradigm capable solving environmental problems associated internal combustion engine vehicles icevs however evs also environmental impacts directly related country electricity generation mix countries without environmentally friendly electricity generation mix evs may effective lowering greenhouse gas ghg emissions study analyzed extent ghg emissions associated evs differs among countries world relation domestic electricity generation mix compared results ghg emissions icevs countries high percentage fossil fuels electricity generation mix showed high ghg emissions evs countries evs associated ghg emissions icevs countries policies based positive environmental impact evs may reconsidered addition different policies may need considered different vehicle types compact car suv etc ability evs reduce ghg emissions compared icevs varies vehicle type elsevier ltd rights reserved
study evaluated effectiveness osteoporosis self assessment tool asians osta screening osteoporosis elderly male population chengdu area china lunar prodigy advance bone densitometer used measure bone mineral density healthy males age years men osta scores osta assigned low risk moderate risk high risk group respectively scores measured dual energy ray absorptiometry different sites compared across groups bone mineral density lumbar spines left femur sites decreased gradually age increasing age screening sensitivity osta osteoporosis lumbar spine femur gradually increased whereas specificity decreased areas receiver operating characteristic curves osta index different age groups different sites therefore osta index demonstrated value screening osteoporosis men age years significant differences effectiveness observed among different age groups
multiple system atrophy msa demyelinating neurodegenerative disorder characterized accumulation aggregated synuclein asyn inside oligodendrocyte precursors mature oligodendroglia neurons msa dysfunction associated loss trophic factor production glial neuronal cells report recombinant wild type human asyn uptake oln oligodendroglia cell line reduced brain derived neurotrophic factor bdnf expression furthermore oln cells stably transfected human wild type msa associated mutant asyn produces neuronal glial inclusions reduced bdnf mrna nearly unmeasurable qpcr levels curiously another msa associated asyn mutant also produces neuronal glial inclusions caused trend toward bdnf mrna reduction transfected oln cells suggests oligodendrocyte associated bdnf loss occurs response specific asyn types treating oln cells fty fingolimod gilenya food drug administration fda approved therapeutic multiple sclerosis counteracted bdnf downregulation asyn oln cells fty also restored bdnf mrna oln cells treated recombinant asyn measured qpcr semiquantitatively agarose gels immunoblots confirmed fty increased histone acetylation oln chromatin immunoprecipitation assays showed increased acetylated histone bdnf promoter fty moreover oln cells treated valproic acid classic histone deacetylase inhibitor confirmed increasing acetylated histone levels increases bdnf expression cumulatively data suggest fty associated histone deacetylase inhibition stimulates bdnf expression oligodendroglial cells raising possibility msa patients may also benefit treatment fty elsevier ltd rights reserved
multicentric castleman disease polyclonal lymphoproliferative disorder recently new variant disease reported named tafro syndrome acronym thrombocytopenia ascites myelofibrosis renal dysfunction organomegaly year old woman presented hospital dyspnea exertion high fever laboratory tests revealed anemia thrombocytopenia proteinuria computed tomography revealed large anterior mediastinal mass mild splenomegaly bilateral pleural effusion pericardial effusion mild systemic lymphadenopathy guided biopsy unable establish definitive diagnosis resected mediastinal mass diagnostic therapeutic purposes pathological findings consistent hyaline vascular type castleman disease diagnosed tafro syndrome description patient tafro syndrome large mass first case tafro syndrome treated debulking surgery
computational topology vibrant contemporary subfield article integrates knot theory mathematical visualization previous work computer graphics developed sequence smooth knots shown converge point wise piecewise linear approximant extended isotopic convergence discovery aided computational experiments sufficient conditions attain isotopic equivalence determined priori sufficient conditions need tight bounds providing opportunities optimizations results presented facilitate computational experiments theory knots also known stick knots theory less mature smooth knots elsevier rights reserved
purpose evidence exists regarding time course clinical relevance muscle strength improvements following resistance training people multiple sclerosis pwms purpose study investigate temporal course clinical meaningfulness changes strength induced high intensity resistance training whether changes impact muscle endurance fatigue functional outcomes methods pwms predominantly unilateral hyposthenia ankle dorsiflexors underwent week isokinetic training affected ankle dorsiflexion muscles maximal strength measured baseline training weekly basis end intervention post week follow muscle endurance fatigue mobility walking outcomes assessed baseline post follow reproducibility responsiveness analyses performed results significant gains muscle strength already detected weeks training improvements following weeks improvements exceeded cutoff values relevant changes also positively correlated improved muscle endurance fatigue mobility measures none observed changes muscle performance functional outcomes retained follow conclusions preliminary evidence showed weeks high intensity resistance training induces consistent meaningful improvements muscle performance ankle dorsiflexors pwms findings may practical dose response cost effectiveness implications management induced muscle weakness potentially enhancing understanding response training exhibited pwms
describe experiment satellite radiowave probing ionosphere modified powerful waves heating facility tromso norway may amplitude scintillations variations phase vhf signals russian navigational satellites passing heated region observed show large scale electron density irregularities several tens kilometers size small scale ones hundreds meters kilometers generated radiation maximum effects caused small scale irregularities detected satellite signals observed directions sector approximately parallel geomagnetic field lines although large scale structures detected within much larger area properties small scale irregularities electron density fluctuations investigated applying statistical analysis studying experimental model mean values logarithm relative amplitude signal results indicate satellite radio probing supporting diagnostic technique ionospheric heating add valuable information studies effects produced modification
pregnancy successful safe therapeutic management patients possible lower burden disease often topical therapy combination intensive basic skin care sufficient drug therapies may also used often systemic diseases autoimmune diseases psoriasis early change therapy also key planned pregnancies treatments switched adjusted reduced closely monitored another point consider keep drug dosing low possible without occlusion local therapy short termed exception autoimmune malignant diseases interdisciplinary collaboration obstetrics gynecology rheumatology internal medicine dermatology well pharmacologists utmost importance
focused attention meditations shown improve psychological health wellbeing nowadays integral part many psychotherapies research neural correlates focused attention meditation increasing findings vary whether meditations associated high low activity default mode network dmn clarify relationship focused attention meditation activity dmn regions may helpful distinguish internal external attention well different phases within one meditation focused attention meditation practitioner switches mindful attention mind wandering refocusing employed thought probe paradigm study neural correlates different phases twenty healthy meditation naive participants introduced external mindfulness sound internal mindfulness breathing attention meditation practiced meditation home four consecutive days performed focused attention meditations fmri scanning four runs alternating internal external attention pseudorandom intervals participants asked whether focused task mindful attention distracted mind wandering mindful attention brain regions typically associated dmn medial prefrontal cortex posterior cingulate cortex left temporoparietal junction showed significantly less neural activation compared mind wandering phases reduced activity dmn found external internal attention stronger deactivation posterior cingulate cortex internal attention compared external attention moreover refocusing mind wandering associated activity left inferior frontal gyrus results support theory mindful attention associated reduced dmn activity compared mind wandering independent practitioner attention focus internal external
extracting owl ontologies relational databases extremely helpful realising semantic web vision however approaches context often drop many expressive features owl highly expressive axioms detected database schema alone instead require combined analysis database schema data paper present approach transforms relational schema basic owl schema enhances rich owl constructs using schema data analysis techniques rely user verification features furthermore apply machine learning algorithms help ranking resulting features based user supplied relevance scores testing tool number databases demonstrates proposed approach feasible effective
effectiveness limestone sand fines material finer controlling durability performance slag cement concrete investigated experimental program slag cement concrete specimens incorporating limestone aggregate produced two water cement ratios leading moderate high level durability linear regression analysis applied evaluate rates significance change durability performance parameters concrete varied levels fines content ranging significant relationships performance parameters compressive strength water penetration resistance chloride migration coefficient resistivity abrasion resistance fines content found statistical analysis depending water cement ratio compared low water cement ratio concrete specimens contribution fines durability prominent concrete mixes high water cement ratio paper also presents case study durability assessment going marine infrastructure project involving izmit bay crossing suspension bridge findings obtained field conform output research elsevier ltd rights reserved
background alcohol ingestion influences sensory motor function overall well individuals detecting alcohol induced impairments gait daily life necessitates continuous unobtrusive gait monitoring system objectives paper introduces development use non intrusive monitoring system detect changes gait induced alcohol intoxication methods proposed system employed pair sensorized smart shoes equipped pressure sensors insole gait features extracted adjusted based individual gait profile adjusted gait features used train machine learning classifier discriminate alcohol impaired gait normal walking experiment pilot study twenty participants completed walking trials meter walkway measure sober walking alcohol impaired walking using smart shoes results proposed system detect alcohol impaired gait accuracy pressure value analysis person dependent model classifier applied statistical analysis revealed single feature discriminative detection gait impairment conclusions alcohol induced gait disturbances detected smart shoe technology automated monitoring ubiquitous environment demonstrated personal monitoring machine learning based prediction could customized detect individual variation rather applying uniform boundary parameters gait
conducted retrospective cohort study using randomly selected medical charts women reporting history partner violence women history partner violence time family planning abortion appointment per group analyzed lifetime history partner violence odds lifetime history abortion miscarriage number birth control problems closely match timing analyzed subsample women reporting current violence versus time abortion appointment differences gestational age medical versus surgical method choice return follow visit adjusting years risk demographic characteristics women past history partner violence likely ever one abortion likely problems birth control repeat abortions miscarriages women history violence women current partner violence also likely receiving abortion later gestational age found differences groups return abortion follow visit choice surgical versus medication abortion findings support screening influence partner violence reproductive health related safety planning
background temperament character traits adolescents nonsuicidal self injury disorder nssi might differentiate without comorbid borderline personality disorder bpd methods participants female adolescents nssi disorder without bpd nssi bpd adolescents nssi disorder bpd nssi bpd clinical controls nonclinical controls temperament character traits assessed junior temperament character inventory impulsivity barratt impulsiveness scale nogo task results adolescents nssi disorder scored significantly higher novelty seeking harm avoidance lower persistence self directedness cooperativeness nssi bpd group scored even higher nssi bpd group novelty seeking harm avoidance lower persistence cooperativeness adolescents nssi reported higher levels impulsivity group however difference found nogo task conclusions results provide evidence distinct diagnostic entity nssi disorder
experimental study conducted investigate impact violent computer games state hostility state anxiety arousal participants undergraduate students aged years experimental sessions participants filled self report measures concerning video game habits also pre tested aggressiveness trait anxiety physiological responses heart rate skin conductance measured experiment playing information state hostility state anxiety collected results showed participants played violent game reported significantly higher state hostility support assumption aggressive personality moderates effect playing violent game state hostility
rainwater underutilized water resource become important recent years due severe water logging water shortage cities evaluation rainwater harvesting potential fundamental importance planning rainwater harvesting systems management policies study used minute interval rainfall data water mass balance method coupling urban hydrological processes assess annual rainwater availability potential rap different underlying surfaces urban areas beijing inside ring road estimated total rap million rainwater could effectively harvested use among rooftops highest harvesting ratio contributed half total rap indirect use rainwater achieved infiltration facilities concave green land construction porous brick pavement increase amount rainfall infiltrates soil respectively rainwater harvesting utilization could serve significant water source urban areas beijing
research generic analytical model voltage response fractance time domain often cited various disciplines control engineering electronic engineering etc proposed model applied fractance order type current excitation found beneficial various fractance involved disciplines stated crucial basis development technology internet things due generality
presented paper describes design implementation functions twitter feeds analysis visualization based combination analytical technologies big data processing tools main idea utilize hadoop processing framework storage computational capabilities analytical tasks designed implemented language purposes decided use hadoop hdfs mapreduce storage handling processing logic connected via tessera framework analytical functions written results analysis presented graph visualizations visualizations implemented using trelliscope framework flexible visualizations large complex data environment fast effective fashion
paper presents strategy based approach designing inserting helicopter vibration isolation systems mountable mechanisms springs adjustable sign changing stiffness system stiffness control procedure extend effective area stiffness control presented set parameters sensitivity analysis practical mechanism design formulated validity flexibility approach illustrated application crewmen seat suspensions vibration isolators equipment protection containers strategy provides minimization vibrations especially infra low frequency range important crewmen efficiency safety equipment also would prevent performance degradation operating systems effectiveness demonstrated measured data obtained development parallel flight tests new operating systems published elsevier ltd
background propiverine hydrochloride antimuscarinic drug used overactive bladder syndrome methods two studies performed one patients open angle glaucoma oag treated topical beta blockers one patients narrow angle glaucoma nag treated pilocarpine topical beta blockers patients treated randomized place controlled double blind parallel group fashion attribution placebo treatments single blind dose morning day baseline double blind matched placebo afternoon day morning day results morning day trough mean serum concentrations coefficient variation oag nag hours dosing respectively treatment led prompt oag gradient nag increase pupil diameter pud maximum difference confidence interval oag nag respectively however average increase intraocular pressure iop increase note worthy safety relevant individual iop values changes thereof effect visual acuity accommodation conclusions week treatment appeared safe oag patients treated topical beta blockers nag patients treated topical pilocarpine beta blockers irrespective whether eyes previously treated glaucoma surgery laser therapy
work reviewing two different ways solve riccati systems able present extensive list families integrable nonlinear schrodinger nls equations variable coefficients using riccati equations similarity transformations able reduce standard nls models consequently construct bright dark peregrine type soliton solutions nls variable coefficients important application solutions riccati equation parameters means computer algebra systems shown parameters change dynamics solutions finally test numerical approximations inhomogeneous paraxial wave equation crank nicolson scheme analytical solutions found using riccati systems solutions include oscillating laser beams laguerre gaussian beams
recently proposed neural substrate mediating smile production might play key role also recognition others smile hypothesis however challenged difficulties eliciting ecological smiling standard laboratory settings report case difficulties overcome combining electrical stimulation intracranial electroencephalogram recording patient drug resistant focal epilepsy stimulation pregenual anterior cingulate cortex pacc elicited smiling facial expression leads exploring pacc showed increase gamma band activity observation video clips depicting actors laughing relative video clips depicting actors crying producing neutral expression findings indicate smile production recognition encoded pacc support role region social cognition
research shows anxiety may relate following goal conflict resolution distraction automatic detection threat related stimuli investigate relationships used modified stroop task fearful happy emotional target faces overlaid either emotionally neutral emotionally congruent emotionally incongruent distracting words trait anxiety related speed accuracy trade seemed primarily reduce accuracy incongruent trials target fearful faces overlaid emotionally conflicting word happy offer explanation effect based upon theories positive stimuli threat related stimuli differentially affect information processing future studies seek verify anxiety related speed accuracy trade mechanism activated elucidate positive stimuli affect anxiety threat related stimuli elsevier ltd rights reserved
hexanitro hexaazaisowurtzitane high energy nitramine explosive high mechanical sensitivity trinitrotoluene tnt insensitive means high performance explosive reveal significant importance smart material functionality energetic energetic crystals stability mechanical explosive properties tnt crystal tnt crystal crystal studied non hydrogen bonded non covalent interactions govern structures energetic energetic crystals however difficult accurately calculate non covalent intermolecular interaction energies paper local conformation intricate non covalent interactions effectively mapped analyzed electron density rho derivatives results show two components tnt connected mainly nitro aromatic interactions nitro nitro interactions steric interactions tnt could confronted attractive interactions moreover scatter graph tnt crystal reveals reason tnt brittle detailed electrostatic potential analysis predicted detonation velocities impact sensitivity compounds increase sequence tnt crystal tnt additionally tnt crystal better malleability pure components demonstrates capacity feasibility realizing explosive smart materials crystallization even strong hydrogen bonding schemes generally lacking energetic materials
biomimetic robots used explore explain natural phenomena ranging coordination ants locomotion lizards developed series decision architectures inspired information exchange host organism microbiome first modeled biochemical exchanges population synthetically engineered coli built physical differential drive robot contained integrated onboard computer vision system relay established simulated population cells robot microcontroller placing robot within target containing two dimensional arena explored different aspects simulated cells robot microcontroller could integrated form hybrid decision architectures found distinct decision architectures allow develop models computation specific strengths runtime efficiency minimal memory allocation taken together hybrid decision architectures provide new strategy developing bioinspired control systems integrate living nonliving components
summary aim study correlate radiometric indices cone beam computed tomography cbct images bone mineral density bmd postmenopausal women quantitative cbct indices used screen women low bmd purpose osteoporosis disease characterized deterioration bone tissue consequent decrease bmd increase bone fragility several studies performed assess radiometric indices panoramic images low bmd predictors aim study correlate radiometric indices cbct images bmd postmenopausal women methods sixty postmenopausal women indications dental implants cbct evaluation selected dual energy ray absorptiometry dxa performed patients divided normal osteopenia osteoporosis groups according world health organization criteria cross sectional images used evaluate computed tomography mandibular index ctmi computed tomography index inferior cti computed tomography index superior cti student test used compare differences indices groups intraclass correlation coefficient icc results statistical analysis showed high degree interobserver intraobserver agreement measurements icc mean values ctmi cti cti lower osteoporosis group osteopenia normal patients comparing normal patients women osteopenia statistically significant difference mean value cti conclusions quantitative cbct indices may help dentists screen women low spinal femoral bone mineral density refer postmenopausal women bone densitometry
widespread adoption mobile devices explosive growth spatio temporal data location based services lbs become indispensable technology daily lives key characteristics lbs applications include high rate time stamped location updates many concurrent historical present predictive queries commercial providers lbs must support three kinds queries address high update rates employ relational databases purpose traditional databases unable cope growing demands many lbs systems support spatio temporal indexes within databases limited tree based approaches although number advanced spatiotemporal indexes proposed research community support historical queries indexing techniques support historical queries unable sustain high update query throughput typical lbs technological trends involving increasingly large main memory growing processing core count offer opportunities address issues present several key ideas support high performance commercial lbs exploiting memory database techniques taking advantage large memory available modern machines system maintains location data index past days memory older data index kept disk propose memory storage organization high insert performance also introduce novel spatio temporal index maintains partial temporal indexes versioned grid structure partial temporal indexes organized compressed bitmaps extensive evaluation demonstrate system supports high insert query throughputs outperforms leading lbs system significant margin
article contains description structure software functional capabilities scope purposes application group profile computer technique technique rests conceptual basis microgroup theory includes new modified questionnaires unique algorithm tied questionnaires identification informal groups yields wide range data group whole indices informal group indices group member indices technique used study different types groups production work groups design teams military units etc academic school classes student groups sports
increasing evidence suggests altered immune functions related pathophysiology schizophrenia relatively little information available toll like receptors tlrs implicated recognition molecular patterns associated pathogens internal cellular damage signals using immunophenotyping flow cytometry investigated tlrs monocytes foxp regulatory cells reg activated cells act drug naive patients schizophrenia week period antipsychotic treatment risperidone olanzapine compared healthy control individuals drug naive patients schizophrenia exhibited increased percentage tlr tlr monocytes tlr reg act cells end treatment period observed normalized tlr monocytes regulation tlr monocytes reg act cells mean fluorescent intensity values indicating receptor density consistent findings drug naive state treatment higher percentages tlr tlr monocytes correlated severe cognitive deficits positive negative general clinical symptoms associated tlrs significant differences patients receiving olanzapine risperidone results indicate abnormal expression tlr detected earliest stage schizophrenia modulated antipsychotics immunological alterations unmedicated schizophrenia patients may linked cognitive deficits elsevier inc rights reserved
paper elaborates issue representation administrative information form hierarchies related events relational server efficient manipulation data models data representation operations data considered possible solutions compared terms performance safety
response inhibition suggested dysfunctional obsessive compulsive disorder ocd however process involves intentional cognitive control correspond automatic emergence stereotyped thoughts behaviours usually reported patients ocd present study excessive facilitation unintentional processes assessed ocd using computerized mirror pointing task cmpt seventy six volunteers participated study including patients ocd healthy controls cmpt administered participants score appropriateness sensorimotor adaptation mirror inversion computed initial deviation angle ida precedes intentional readjustment movement results showed throughout trials cmpt ida score remained significantly abnormal patients ocd comparison control participants analyses ida scores ocd revealed clear tendency keep natural visuomotor processing rigid unadapted mirror condition irrespective physical requirements environment patients ocd showed strong tendency initiate movements per previously consolidated although unadapted sensorimotor mapping suggests tendency excessive facilitation unintentional stereotyped processes studies conducted question using tasks sensitive cognitive processes visuo spatial abilities elsevier ltd rights reserved
chemokines promising biomarkers immune activation inflammation evidence chemokine abnormalities schizophrenia relationship clinical factors remains inconclusive aimed understand chemokine related diagnostic differences clinical correlates using comprehensive panel studying large well characterized sample adults without schizophrenia studied outpatients schizophrenia schizoaffective disorder healthy comparison individuals years age clinical measureswere obtained plasma levels chemokines assessed usingmultiplex immunoassay schizophrenia differenceswere tested chemokine adjusting age gender bodymass index current smoking status also examined whether age gender relationships differed diagnostic groups using logistic regression created chemokine index explored clinical correlates levels monocyte chemoattractant protein mcp ccl macrophage inflammatory protein mip ccl eotaxin ccl thymus activation regulated chemokine tarc ccl macrophage derived chemokine mdc ccl significantly higher persons schizophrenia hcs group differences tarc reduced adjusting covariates linear combination eotaxin mdc levels positively associated age duration schizophrenia severity negative symptoms levels chemokines neuroimmune regulatory effects higher individuals schizophrenia particularly older chronic patients treatments aimed normalizing chemokine levels might improve mental physical health among schizophrenia patients age published elsevier right arrow
introduction numerous clinical practice guidelines emphasis placed need coordinated care psoriatic arthritis psa rheumatologists objective develop experience based points consider facilitating implementation multidisciplinary units dermatology rheumatology management patients psa methods scientific committee rheumatology dermatology experts management psa experience joint care discussed critical aspects multidisciplinary psa units discussion became basis delphi survey two rounds submitted panel specialists rheumatology dermatology involved psa units statements practices reached consensus summarized elaborated results two delphi rounds agreement reached proposed statements included justification units objectives utilities well operational aspects units minimal ideal premises referral criteria necessary resources statements compiled points consider conclusions consensus offers points consider including premises recommendations development specialized units management psa based expert opinion trust guidelines may facilitate implementation future
context dehydroxymethylepoxyquinomicin dhmeq originally developed analog antibiotic epoxyquinomicin specific potent inhibitor kappa shown possess promising potential anti inflammatory anti tumor agent objective study examines dhmeq effect therapeutic potential atopic dermatitis like lesions materials methods lesions chronically induced repetitive alternative application dinitrochlorobenzene dncb oxazolone ears balb mice mice externally treated dhmeq ointment macroscopic microscopic changes skin lesions observed recorded results dhmeq inhibited ear swelling relieved clinical symptoms like lesions induced dncb balb mice histopathology examination illustrated significantly decreased dncb induced epidermal thickness infiltration inflammatory cells count mast cell elevated level immunoglobulin ige serum mrna levels interferon gamma ifn gamma interleukin ear tissues also suppressed dhmeq discussion conclusion study indicated dhmeq would useful treatment
set open cell foams growing porosities growing pore nominal diameters artificially generated firmly connect normal spectral emittances textural features work strictly focused foams composed opaque struts optically smooth surfaces compute normal spectral emittances monte carlo ray tracing code carefully used indirect method based kirchhoff laws monte carlo ray tracing code considers complex refractive index solid phase constituting struts foams particular attention therefore paid performing calculation absorption indices preserve opacity strut thorough analysis ray transport within foams representative elementary volumes used computing homogenized radiative properties known beforehand general simple law established connects normal spectral emittance one hand open porosity complex index refraction hand field thermal conversion solar energy example new law gives relevant insight radiative performance highly porous foams virtually coated materials known possessing undeniable spectral selectivity shaped dense samples elsevier ltd rights reserved
resveratrol caloric restriction mimetic naturally occurring polyphenolic compound antioxidant anti inflammatory properties oxidative stress implicated etiology number neuropsychiatric disorders including generalized anxiety schizophrenia study investigated anxiolytic antipsychotic potentials resveratrol murine models anxiety schizophrenia mice pretreated resveratrol carboxymethyl cellulose days subjected behavioural tests day anxiolytic activity resveratrol determined using hole board staircase tests anti psychotic property evaluated via apormorphine induced stereotypy swim induced grooming tests although resveratrol significantly reduce mean number head dips doses used hole board test significantly decreased mean episodes rearing without significantly altering total number upward steps climbed staircase test resveratrol significantly reduced mean climbing scores first ten minutes apormorphine induced stereotypic climbing significantly decreased episodes total duration swim induced grooming mice administration resveratrol doses used study produced anxiolysis anti psychotic effects mice
paper studies time complexity gene expression programming based maintaining elitist gep using theory markov chain technique artificial fitness level properties transition matrices gep analyzed based properties upper lower bounds average time complexity gep obtained furthermore upper bound estimated determined parameters gep algorithm theoretical results acquired paper used analyze gep solving function modeling clustering problem last set experiments performed problems illustrate effectiveness theoretical results results show upper bound expected first hitting time used direct algorithm design gep
synthesis nanocrystalline silver nanosilver nag major aim work nanosilver nanomaterial great interest due special biocidal properties particularly desirable various fields medicine cosmetology materials engineering construction others aimed develop new method preparation nanosilver would completely environmentally friendly paper discusses process obtainingnanosilvervia chemical reduction silver nitrate served source silver ions glucose responsible reduction stabilizing agent natural protein substance gelatin added inhibit growth metallic agglomerates use gelatin stabilizing factor glucose reducing agent interfere natural environment use substances renders method environmentally friendly consistent principles green chemistry investigated influence independent variables namely molar ratio reducer silver ions mass content stabilizer temperature resulting suspension properties particle size determined using dynamic light scattering study carried zetasizer nano provided information electrokinetic potential reflects stability colloidal system atomic force microscopy used image obtained suspension
paper discuss sectionalization linear tail biting trellis lafourcade vardy investigated basic property sectionalization conventional trellis proofs basic properties based conventional trellis structure fails generalized linear tail biting trellis derive proofs construction koetter vardy trellis properties sectionalization conventional trellis preserved linear tail biting trellis especially prove necessary condition optimal sectionalization linear tail biting trellis
atrial fibrillation common arrhythmia cardiac surgery pathophysiological point view myriad factors trauma atrial dilation ischemia mechanical myopericarditis autonomic imbalance loss connexins nest remodeling inflammation sutures dysfunction caused postextracorporeal circulation contribute postoperative atrial fibrillation poaf resulting longer hospital stay consequently higher cost recent studies showed short fragments rna called microrna mirna contribute development several cardiovascular diseases including aim study evaluate levels circulating mirnas mir involved poaf patients submitted coronary artery bypass graft surgery grouped poaf patients without poaf patients results showed older age longer clamp time days intensive care unit well longer total hospital stay poaf group preoperative levels circulating mirnas similar analysis mirnas revealed significantly lower circulating levels mirna poaf group postoperative period receiver operating characteristic roc analysis showed area roc curve mir mir predicting confidence interval respectively data suggests circulating mirna may involved underlying biology postoperative development
develop systematic framework joint modeling returns multiple daily realized measures assume linear state space representation log realized measures noisy biased estimates log daily integrated variance least due jensen inequality incorporate filtering methods estimation latent log volatility process dependence daily returns realized measurement errors leads develop two step estimation method parameters model specification estimation method computationally straightforward even stochastic volatility model non gaussian return innovations leverage effects extensive empirical study nine dow jones stock return series reveals measurement errors become significantly smaller filtering forecasts model outperforms set recently developed alternatives
objectives study aimed investigate effect trospium chloride cognitive function postmenopausal women treated overactive bladder oab methods randomized double blind placebo controlled trial conducted april april women aged years older seeking treatment oab randomized either trospium chloride daily placebo baseline cognitive function assessed via hopkins verbal learning test revised hvlt mini mental status exam mini mental status digit span trails trails epworth sleepiness scale cognitive function reassessed week week priori power analysis determined subjects needed per group results although women enrolled randomized trospium placebo completed assessment trospium placebo mean age years white previously taken oab medication primary outcome difference hvlt total score trospium placebo groups week also differences based cognitive tests therewas correlation age following week tests hvlt total score hvlt total recall subscale trails trails linear regression model found hvlt total score decreased points increased year age conclusions women aged years older changes cognitive function taking trospium placebo cognitive function correlated age
study addressed individual differences two types prosocial behavior internet helpgiving sharing moral courage questionnaire measure behaviors developed investigated effects big five personality traits sadistic traits values help giving moral courage found willingness help internet promoted open personality relationship partly moderated high weekly use social media willingness act morally courageous promoted open personality inclination toward sadism self transcendence values surprisingly relationship moral courage sadistic traits moderated time spent online willingness donate charity fostered benevolence universalism values future studies need replicate results behavioral observations
permeable geotextile tubes usually made sewing geotextile sheets together filling clay slurry sand however tensile strength seamed woven geotextile material usually half seamless geotextile sheet new seam method proposed improve tensile strength seamed woven geotextile material main idea method reinforce geotextile area pin hole side weakest part traditional seaming methods test results show seam reinforced percentage ratio tensile strength strength seamless geotextile sheet improved
soil scientists usa created large national database written soil profile descriptions follow well defined set rules describing soil morphological properties interpreting soil descriptions skill requires considerable practice experience writing soil description straightforward recreating visual representation soil profile written description difficult far generalized approach translating written tabular soil descriptions visual representations propose novel procedural modeling approach inspired procedural models commonly used field computer graphics framework takes tabular soil morphological data soil profile descriptions textual input translates visual features based parametric models models used generate two dimensional soil profiles generate three dimensional interactive models allow rotation scaling forms visual explorations procedural modeling technique enables user generate soil profile visual representation small amount data images need stored generated needed
background main purpose study analyze correlation erectile function hormonal pattern year mortality risk using charlson comorbidity index cci methods cross sectional analysis consecutive men attending sexual medicine men health outpatient clinic july july conducted inclusion criteria age years old history pelvic surgery radio cryotherapy treatment gonadotropin releasing hormone analogues antiandrogenic drugs variables including age height weight body mass index cci erection hardness score ehs questionnaire hormonal pattern testosterone sex hormone binding globulin shbg biochemical data prospectively recorded free bioavailable testosterones calculated using vermeulen formula low levels defined multivariate analysis performed relationship study population variables year mortality risk erectile dysfunction low testosterone levels related entities affecting cardiovascular health diabetes metabolic syndrome heart disease cci validated tool predict mortality using items tool predict year mortality risk results one hundred eighty patients included mean age years old rate low levels found men univariate analysis variables age ehs reactive protein related higher mortality risks according cci multivariate analysis variables age reactive protein related higher mortality risks conclusion age reactive protein related higher estimated year mortality risk using cci
earlier evidence predominantly supports women ethical men replication hypothesis testing study examined whether feminine gender roles better predictor ethical attitudes ethical behaviors corporate responsibility values biological sex four hundred ten management students two technical institutes eastern india participated study along socio demographic variables questionnaire inventories used assess gender roles ethical attitudes ethical behaviors corporate responsibility values inventories acceptable reliability validity results suggested confounding effects age caste rural urban origin controlled women manifest higher corporate responsibility values men embody similar ethical attitudes ethical behaviors men furthermore feminine roles participants found consistent potent direct predictors ethical attitudes ethical behaviors corporate responsibility values biological sex hence individuals feminine roles may better suited ethical responsibilities
study microstructure property relationships processing history leading relationships core materials engineering historical evolution understanding processing microstructure property relationships largely relied empirical evidence turn helped catalyze theories iteratively linking modeling experiments helped maturation process materials design power modeling methods increased yet unified mathematical formalism seamlessly connect materials chemistry kinetics micro mesoscale information despite decades work article provide overview microstructural informatics permits one capture interaction processing variables influence microstructure chemistry property correlations includes particular focus use manifold representations data compression methods defining microstructure chemistry property relationships explain known materials behavior aid designing new processing pathways materials enhanced properties concept identifying irreducible representation microstructure introduced
study clarified factors affecting increase jump distance novice increased number steps approach run long jump discusses training task designed improve performance long jump twenty eight male students novices long jump take part sport activity regularly participated study performed long jump run ups six twelve strides take motions participants captured high speed digital camera fps two dimensional motion analysis students increased number steps approach run jump distance approach velocity increased horizontal deceleration take phase remained almost unchanged vertical velocity take contact time decreased change rate jump distance six twelve steps approach run positive correlation change rates approach velocity vertical velocity negative correlation change rate contact time previous study using athletes participants athletes increased jump distance increased number steps approach run present study however many students increase jump distance change rate jump distance wide distribution therefore divided students groups according whether participant change rate jump distance lower higher average change rate participants although groups increased horizontal velocity touchdown lengthened run participants low group increase jump distance vertical velocity take decreased additionally comparison athletes students lower vertical velocity take horizontal deceleration take novice thus learn proper technique take generate vertical velocity horizontal deceleration authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering rmit university
air pollution topic currently studied address well known health problems arise use esp electrostatic precipitator treatment submicron particles sources small scale combustion systems presents advantages comparison possible devices study new esp prototype geometry based separating discharge electrode support gas stream path designed constructed tested gas stream small size diesel internal combustion engine used good esp behavior moderate time periods verified achieving average collection efficiencies thermogravimetric sem eds scanning electron microscopy energy dispersive ray spectroscopy analyses performed influence regulation power value discharge electrode effective length collection efficiency evaluated higher removal efficiencies linked higher power values higher discharge electrode effective lengths high impact operating time observed different discharge electrode geometries tested indicating increase collection efficiency power increased stainless steel electrodes opposite trend threaded rod electrodes elsevier ltd rights reserved
theory dissipativity well developed controllable systems appropriate definition dissipativity context uncontrollable systems terms existence storage function namely function along every system trajectory rate change time instant power supplied system time however even supplied power expressible terms external variables dissipativity property uncontrollable systems crucially hinges whether storage function depends variables unobservable hidden external variables paper investigates key aspects cases also proposes another intuitive definition dissipativity three definitions compared show drawbacks one definition addressed another dealing first observable storage functions conditions two uncontrollable poles add zero dissipativity strict frequency tends infinity prove dissipativities system controllable part equivalent use behavioural approach formalising key notions system behaviour set system trajectories prove storage functions unobservable lossless uncontrollable systems known however unobservable storage functions result certain fallacious examples lossless systems propose intuitive definition dissipativity system behaviour called dissipative embedded controllable dissipative superbehaviour prove embeddability results use resolve fallacy example termed lossless due unobservable storage functions next show quite unreasonably embeddability definition admits behaviours strictly dissipative strictly antidissipative drawbacks embeddability definition context rlc circuits finally related inability realise synthesise special one port electrical network called nullator using passive electrical components
issue providing information security data computing resources grid networks reviewed specific features architecture distributed computing networks based grid platforms analyzed security threats specific grid systems typified available measures ensuring security grid systems considered drawbacks indicated set applied issues associated ensuring grid protection unauthorized access defined
study distributed delta vertex coloring delta edge coloring problems problems among important intensively studied problems distributed computing despite intensive research last years deterministic algorithms problems sublinear delta time known far moreover restricted scenarios related problems lower bounds ohm delta goos hirvonen suomela kuhn wattenhofer szegedy vishwanathan question possibility devise algorithms overcome challenging barrier one fundamental questions distributed symmetry breaking barenboim elkin goos hirvonen suomela kuhn panconesi rizzi article settle question delta vertex coloring delta edge coloring devising deterministic algorithms require delta log delta log time static dynamic faulty settings term log unavoidable view lower bound linial moreover delta vertex coloring delta edge coloring devise algorithms root delta log deterministic time roughly quadratic improvement comparing state art requires delta log time barenboim elkin kuhn panconesi rizzi results actually general since apply also variant list coloring problem generalizes ordinary coloring results obtained using novel technique coloring partially colored graphs also known fixing partition uncolored parts small number subgraphs certain helpful properties color subgraphs gradually using technique employs constructions polynomials novel way construction inspired algorithm linial ordinary delta coloring however sophisticated construction differs linial several important respects new insights using systems polynomials allow significantly speed delta coloring algorithms moreover allow devise algorithms running time also complicated settings dynamic faulty networks
produce reliable estimates size vital rates given population important boundaries population study clearly defined particularly critical large migratory animals levels sustainable harvest based estimates small errors may serious long term consequences population populations delineated rates exchange adjacent populations determined accounted corrected calculating abundance based mark recapture data using satellite radio collar locations polar bears western canadian arctic illustrate one approach delineating wildlife populations integrates cluster analysis methods determining group membership home range plotting procedures define spatial utilization approach flexible respect specific procedures used provides objective quantitative basis defining population boundaries
purpose paper employ graphics processing units numerical solution large systems weakly singular volterra integral equations vies means waveform relaxation methods cuda solver based different kinds iterations developed numerical results large systems vies arising semi discretization space fractional diffusion wave equations presented showing obtained speed imacs published elsevier rights reserved
depression frequently encountered parkinson disease non motor feature reported cause exaggerate motor deficits neurodegenerative events experimental models studied effect chronic mild stress cms pre post pre post exposure mediated depression motor non motor symptoms oxidative stress inflammation brain derived neurotrophic factor bdnf levels related signalling molecules methyl phenyl tetrahydropyridine probenecid mptp induced neurotoxicity mice cms mptp coexposed cbl mice exhibited low neuromuscular strength stride length enhanced oxidative stress inflammation compared cms mpip alone exposed mice coexposure diminished levels bdnf expressions trkb perk erk akt akt creb nigrostriatal regions compared alone exposure cms alone exposed mice showed anxiety related behaviour diminished expression serotonin transporter compared mptp alone injected group post stress exposure mptp mice exhibited lowest motor reflecting higher anxiety state greatest enhancement inflammation reduction protein expression stress cell signalling markers compared pre pre post stress exposed mice however pre pre post cms exposed animals vulnerable oxidative stress compared post stress experienced mptp mice cms mediated depression exacerbates motor non motor symptoms mptp animals modulating oxidative stress various signalling molecules results suggested stress induced nms accelerate neurodegenerative processes progressive expedited manner elsevier inc rights reserved
recent findings provide evidence fungal structures detected brain tissue alzheimer disease patients using rabbit polyclonal antibodies raised whole fungal cells present work developed tested specific antibodies recognize fungal proteins enolase beta tubulin antibody recognizes fungal polysaccharide chitin consistent previous studies number rounded yeast like hyphal structures detected using antibodies brain sections patients structures intracellular strikingly found located inside nuclei neurons whereas fungal structures detected extracellularly corporya amylacea patients also contained enolase beta tubulin revealed selective antibodies devoid fungal chitin importantly brain sections control subjects usually negative staining three antibodies however fungal structures observed control individuals collectively findings indicate presence two fungal proteins enolase beta tubulin polysaccharide chitin cns tissue patients findings consistent hypothesis caused disseminated fungal infection
icam institut catholique arts metiers founded lille today eight campuses offer engineering training france abroad lille nantes toulouse roche sur yon vannes pointe noire douala central africa loyola icam college engineering technology chennai city capital tamil nadu state south india icam remains true jesuit legacy strives educate student become person able take responsibilities real world students icam well known engineering grande ecole france icam pedagogy consists blend theory practice based important collaboration industry three years basic courses every engineering fields mechanical engineering fluid mechanics materials engineering design manufacturing engineering electrical engineering computer sciences fourth year allows students choose courses following areas agrifood construction public works transportation energy information communication technologies courses taught industry professionals giving students accurate vision future jobs fifth year training focuses one semester internship engineer one semester project based research development activities realised collaboration industry projects past five years projects carried teams students working full time one semester supervised icam research fellow lecturer ects credits projects performed subcontracted companies small medium businesses large companies helping students better understanding industrial organisation applications also helps department develop strong links local industry collaborations school industry offer several advantages educational point view student motivation project management suited customer expectations deadlines methodology financial issues taken account hands approach development new materials product process design process improvements quality procedures etc projects examples relais development characterisation optimisation industrialisation new insulation material based recycled textiles staub support environmental compliance foundry toles perforees sambre development evanescent oil cleaning system based luminous flux perforated steel sheets railtech process modeling rails aluminothermic welding
background although eating disorder examination questionnaire version ede one widely used questionnaires eating disorders western countries research addressed psychometric properties ede japanese sample methods explored factor structure ede examined internal consistency derived scales japanese participants study convergent validity eating disorder related psychological measures study distinction derived two body image related factors psychological measures studyiii ede administered undergraduate students study study subsequently assessed two self report measures eating pathology eating attitudes test eat undergraduate students eating disorders inventory edi studyiii another undergraduate students participated examination relationships derived body image related subscales ede psychological measures rosenberg self esteem scale beck depression inventory public self consciousness scale multidimensional perfectionism scale results exploratory factor analysis ede identified four meaningful factors original four ede factors restriction eating concern retained however two factors shape weight concerns combined two different factors fear obesity self esteem based shape weight internal consistency derived four factors adequate relationships edi eat measures demonstrated convergent validity analysis distinction fear obesity self esteem based shape weight revealed self esteem based shape weight significantly associated measures assessing psychopathology related eating disorders conclusions study describes restructured factors ede tested undergraduate students distinction two factors fear obesity self esteem based shape weight may understanding psychopathology eating disorders adolescent japanese subjects facilitate future developments research treatment
investigated effects metacognitive detached mindfulness therapy stress management training hypertension symptoms depression anxiety compared control condition total female patients mean age years randomly assigned one three conditions metacognitive detached mindfulness therapy stress management training control condition blood pressure symptoms depression anxiety decreased baseline post test follow group comparisons showed blood pressure symptoms depression anxiety decreased psychotherapeutic groups control group psychotherapeutic treatment hypertension reduced blood pressure symptoms depression anxiety positive effects observable follow weeks later
annual consumption petroleum products india million metric tons imported indian industrial sector accounts total fuel consumption thermal energy different heating applications temperature range degrees degrees solar collectors meet temperature requirements offer possibility mitigate consumption oil study highlights fact conversion efficiency solar energy much higher process heating electricity generation process heating applications constitute significant share industrial energy consumption paper methodology developed estimate potential integration solar collectors process heating methodology employs process operating temperatures select type solar collectors size solar field estimated taking account thermal heat loads working fluid temperatures processes efficiency chosen solar collectors location based solar irradiance capacity utilization solar collectors proposed methodology validated software tool called system advisor model sam techno economic analysis indicate viability solar systems integration industries therefore consociated parameters economic capital cost fuel oil savings monetary benefits financial payback periods rates returns environmental carbon savings estimated methodology applied select indian industries verify potential quantitatively industries selected include textile pulp paper dairy leather automobile process wise energy demands considered estimating potential fuel requirement offset solar energy terms absolute fuel oil savings monetary benefits carbon savings economic financial parameters mentioned estimated verify capability present market position solar systems sensitivity analyses performed respect solar energy penetration fuel oil prices address viability integration solar energy process heating published elsevier ltd
child maltreatment remains significant problem united states single mothers elevated risk maltreatment due financial limitations lower levels available supports current study investigates whether neigborhood social cohesion informal social control associated child maltreatment sample single mothers examines direct indirect pathways associations occur current study uses analytic sample mothers participated third fourth wave fragile families child wellbeing ffcw study estimate direct associations social cohesion informal social control child maltreatment well two potential mediators maternal depression parenting stress descriptive statistics reveal participants economically disadvantaged approximately possessed least high school diploma ged majority participants african american non hispanic followed hispanic white non hispanic structural equation models show significant associations informal social control either physical abuse neglect social cohesion hand indirectly related physical abuse neglect maternal depression mediated relationship social cohesion maltreatment parenting stress explain relationship social cohesion child maltreatment parenting stress individually associated physical abuse neglect findings suggest maternal depression may important pathway social cohesion affects child abuse neglect single non cohabitating mothers elsevier ltd rights reserved
paper explores use constructivist century learning model implement week long workshop delivered hackathon encourage preuniversity teenagers pursue careers stem particular emphasis computer science irish preuniversity students experience computing vary word processing foundational programming many schools looking introduce ict classroom many students left narrow view computer science twenty one students participated workshop completed pre post surveys free word association exercise areas computing careers computing analysis revealed students motivation learn design process programming inputs outputs wearable technology wearables internet things iot increased following participation also increases confidence inputs outputs wearables iot following participation well changes computing word associations students associating computing computer programming terms rather general terms internet findings suggest combination hackathon event model century learning effective motivating increasing self efficacy preuniversity teenagers number emerging technological contexts iot wearables
paper modeling common rail pressure control high pressure common rail injection system hpcris presented proposed mathematical model high pressure common rail injection system contains three sub systems high pressure pump sub model common rail sub model injector sub model relative complicated nonlinear system mathematical model validated software matlab virtual detailed simulation environment considered hpcris effective model free controller called extended state observer based intelligent proportional integral eso based ipi controller designed proposed method composed mainly referred eso observer time delay estimation based ipi controller finally demonstrate performances proposed controller proposed eso based ipi controller compared conventional pid controller adrc isa published elsevier ltd rights reserved
ditch cleaning drained peatland forests increases sediment loads degrades water quality headwater streams lakes better understanding processes controlling ditch erosion sediment transport systems prerequisite proper peatland management order relate hydrological observations key erosion processes headwater peatlands drained forestry two year study conducted nested sub catchment system treated ditch cleaning two reference sites treated catchment instrumented continuous discharge turbidity monitoring erosion pin measurements changes ditch bed banks time integrated sampling suspended sediment composition results showed ditch cleaning clearly increased transient suspended sediment concentrations sscs suspended sediment yields ssys resulted temporary storage loosely deposited organic sediment ditch network exhaustion sediment storage subaerial processes erosion ditch banks became dominant producing sediment transport recorded sscs higher rising limbs event hydrographs throughout study period indicating transport limited availability erosion prone sediment strong positive correlation rainfall intensity threshold mmh average ssc obtained rising limb hydrographs sub catchment showed soil detachment ditch banks raindrop impact directly increase ssc runoff main catchment outlet variation ssc best explained linear combination initial discharge peak discharge lag time initial peak discharge based factors ditch cleaning slightly increased peak discharges decreased transit times study catchment implications results water pollution management peatland forests discussed copyright john wiley sons ltd
traditionally multi mission applications airborne radar implemented expensive phased array architectures emerging applications civilian surveillance hand prefer low cost low swap space weight power systems study introduces software based solution intends use low cost hardware advanced algorithms processing backend meet remote sensing goals multi mission applications low cost airborne radar platform garmin international used representative example system platform focus study optimal operating mode data quality algorithm development cases weather sense avoid saa applications main challenges solution resolution limitation due small aperture size limitations field view fov scan speed mechanical scanning show basic operational needs satisfied software processing various algorithms concept progress polarimetric airborne radar dual function operations band generation paradox based platform also discussed
achievement maintenance virologic suppression cancer diagnosis associated improved outcomes hiv infected patients studies analyzed virologic immunologic outcomes cancer diagnosis hiv infected patients diagnosis cancer urban clinic population baltimore included review hiv related outcomes hiv rna viral load cell count abstracted compared patients non aids defining cancers nadcs aids defining cancers adcs four hundred twelve patients baseline hiv rna viral load data analyzed diagnoses adcs nadcs patients nadcs higher median age years years higher frequency hepatitis coinfection median baseline lower patients adcs cells cells patients nadcs likely suppressed cancer diagnosis median patients nadcs significantly higher patients adcs months diagnosis higher months significantly patients nadc times adjusted odds suppressed months times odds months compared patients adc diagnosis patients diagnosed adcs nadcs urban clinic setting virologic suppression immunologic recovery improved time patients nadcs highest odds virologic suppression years following cancer diagnosis
jeanette winterson novel sexing cherry story dog woman adopted son jordan live seventeenth century london meeting john tradescant famous botanist gardener jordan found thames named jordan river becomes obsessed travelling exploration discovery accompanies tradescant journeys across world search exotic plants time jordan lot daydreaming mind travelling journeys finds equally realistic important visits magical cities meets fairy tale characters besides since jordan mother twentieth century counterparts said also travel time paper explore different ways travelling described novel purpose discovering extent follows conventions travel genre general also examine travelling context enlightenment period colonial expansion british empire addition since one novel significant topics gender roles paper also focus differences male female travellers male female time
article adopts computer simulation graph theoretic algorithm choose reasonable place convey drugs article use mathematical modeling computer programming solve problem transport drugs
many senior citizens keeping touch modern times put modern technologies good use attempt adapt era avoid computers smart devices senior citizens often also educate ict immune troubles come hand hand ict even psychological issues stem learning new skills high age many even reconsider asking effort worth outcome courses attend might best suited different one another taught operating systems teacher individual attitude accessibility course learning environment huge impact senior attitude quality gained skills article aims describe areas issues senior citizens feel limiting access quality education ict tackled results come qualitative research among selected sample senior citizens took part ict courses published elsevier ltd
critical conditions effect transverse fracture canine teeth carnivores lateral loading analyzed teeth modeled tapered coaxial beams uniformly thin enamel coats stress analysis first carried using beam theory stress intensity factors inward propagating cracks location maximum tensile stress along lingual face determined fracture begins arrested channel cracks within enamel followed stable penetration around tooth dentin point failure two three dimensional finite element models used evaluate full fracture evolution analysis yields explicit scaling relation critical fracture load terms characteristic tooth dimensions notably tooth height base radius role enamel ignored previous strength materials analyses shown important determining precursor crack equilibrium prior full fracture implications concerning allometry briefly discussed elsevier ltd rights reserved
objective obesity comorbidities emerged leading public health concern aim study explore relationship body mass index bmi sleep patterns including duration disturbances methods convenience sample college students completed online survey consisting pittsburgh sleep quality index psqi self reported height weight calculate bmi univariate multivariate logistic regression analyses performed using components psqi predictors overweight bmi results one third participants bmi poor quality sleepers psqi controlling age sex sleep disturbances associated overweight odds ratio confidence interval conclusions sleep disturbances rather sleep duration predicted overweight among young adults consistent recent evidence literature findings support expanding scope wellness programs promote healthy sleep among students
attributional life cycle assessment lca conducted provide comprehensive picture environmental burdens associated cacao production primary processing philippines analysis considered entire system agricultural operations field storage dried beans required produce process ton dried cacao beans inputs include fertilizer pesticides diesel electricity biodegradable plastics outputs include dried beans emissions lambda cyhalothrin mancozeb solid wastes following impacts found associated production ton dried cacao beans human toxicity terrestrial ecotoxicity atmospheric acidification climate change transportation harvesting pest management nutrient management contributed environmental impact categories considered study suggested improvement measures focused reduction fossil fuel consumption judicious application fertilizers pesticides minimize adverse environmental impacts cacao production primary processing amount harmful emissions released impact scores cacao production primary processing generally low may indication cleaner production eco efficiency system results lca study serves feedback mechanism assist philippine cacao industry identifying options improving environmental management production primary processing system
interferon beta ifn beta often discontinued rrms patients due common side effect flu like syndrome fls mechanisms underlying ifn beta induced fls symptoms still unclear endocannabinoid system ecs key regulator pain inflammation thus tested hypothesis ecs could involved fls severity exploring effect genetic polymorphisms functional impact ecs patient reported fls symptoms carriers transient receptor potential vanilloid trpv single nucleotide polymorphism reported greater pain weakness fls study suggests trpv channel involved fls severity elsevier rights reserved
two part paper propose general algorithmic framework minimization nonconvex smooth function subject nonconvex smooth constraints also consider extensions structured nonsmooth problems algorithm solves sequence separable strongly convex problems maintains feasibility iteration convergence stationary solution original nonconvex optimization established framework general flexible unifies several existing successive convex approximation sca based algorithms importantly differently current sca approaches naturally leads distributed parallelizable implementations large class nonconvex problems part devoted description framework generality part customize general methods several multiagent optimization problems communications networking machine learning result new class centralized distributed algorithms compare favorably existing hoc centralized schemes
backgroundaberrant activation catenin signaling wnt dependent wnt independent pathways demonstrated asthmatic airways thought contribute critically remodeling airways yet exact role catenin asthma poorly defined previously reported abnormal expression catenin toluene diisocyanate tdi induced asthma model study evaluated therapeutic efficacy two small molecules xav icg tdi asthmatic male balb mice selectively block catenin mediated transcription methodsmale balb mice sensitized challenged tdi generate chemically induced asthma model inhibitors catenin xav icg respectively given mice intraperitoneally injection resultstdi exposure led significantly increased activity catenin confirmed luciferase assay hbe transfected topflash reporter plasmid treatment either xav icg effectively inhibited activation catenin downregulated mrna expression catenin targeted genes tdi asthmatic mice paralleled dramatically attenuated tdi induced hyperresponsiveness inflammation airway alleviated airway goblet cell metaplasia collagen deposition decreased inflammation well lower levels tgf vegf hmgb conclusionthe results showed catenin principal mediator tdi induced asthma proposing catenin promising therapeutic target asthma
proliferation information major confront faced commerce industry ease customers information proliferation recommender systems introduced improve computational time large scale data process recommendation implemented scalable fault tolerant distributed processing framework paper proposes content based implemented scalable fault tolerant distributed framework hadoop map reduce generate recommendations improved computational time proposed technique map reduce content based recommendation mrcbr implemented using hadoop map reduce follows traditional process content based recommendation mrcbr technique comprises user profiling document feature extraction uses vector space model followed computing similarity generate recommendation target user recommendations generated target user set top documents proposed technique recommendation executed cluster hadoop tested news dataset news items collected using rss feeds stored mongodb computational time mrcbr evaluated speedup factor performance evaluated standard evaluation metric precision recall measure
micrornas mirnas class endogenous evolutionarily conserved small non coding rna molecules mediate posttranscriptional process target gene leading translational repression degradation target mrnas series studies indicated mirnas play important role tumor initiation development progression study found regulation mir frequent event crc tissues compared paracarcinoma tissues study demonstrated mir implicated crc metastasis transwell migration assay revealed elevated mir expression reduces crc cell migration moreover study showed suppression mir expression induces crc cell epithelialmesenchymal transition emt overexpression mir inhibits crc cell emt addition bioinformatics target prediction identified jag putative target mir knockdown mir shown upregulate jag expression furthermore overexpression mir suppressed expression jag consistent results also obtained regulation jag expression mir specified crc tissues moreover overexpression jag induces epithelialmesenchymal transition emt promotes metastasis crc cells decreased notch expression suppresses crc cells metastasis emt together results indicate mir novel regulator colorectal cancer metastasis data suggest mir implicated regulating epithelial mesenchymal transitions directly suppressing downstream target gene jag inactivate notch signaling pathway
based objectives principles order training mode paper aims taking hotel english teaching vocational applied english example clarify reference opinions ministry employment oriented higher vocational education reform clearly stated higher vocational education serve purpose employment oriented path development combining production research production construction management service line culture going stay lingua franca practical ability highly skilled personnel good career goal vocational education personnel training long term education reform development plan issued july clearly states government earnestly perform duties development vocational education vocational education economic social development industrial development planning promote vocational education scale professional set economic social development needs adapt say specialty higher vocational colleges degree docking industrial structure directly related educational level social service capabilities vocational colleges order training model viable effective training method especially recent years favored higher vocational colleges
purpose review marijuana used medicinally recreationally since ancient times interest compounds pain relief increased recent years identification intrinsic endocannabinoid system laid foundation research recent findings synthetic cannabinoids developed synthesized marijuana plant dronabinol nabilone food drug administration approved use dronabinol nabilone chemotherapy associated nausea vomiting hiv human immunodeficiency virus wasting nabiximols cannabis extract approved treatment spasticity intractable pain canada clinical trials studying effect marijuana extracts seizure disorders summary phytocannabinoids identified key compounds involved analgesia anti inflammatory effects compounds found cannabis flavonoids terpenes also investigated individual synergistic effects article review relevant literature regarding medical use marijuana cannabinoid pharmaceuticals emphasis pain headaches
postpartum contraception important lengthening birth intervals improving health women children breastfeeding women choice timing contraception may influence breastfeeding infant growth patterns nonhormonal methods contraception preferred choice breastfeeding women progestin methods comprise viable next option combined hormonal methods contraception containing estrogen progestin may considered third option birth control breastfeeding women objective chapter review current literature recommendations use hormonal nonhormonal methods contraception breastfeeding
many students classrooms belong gamer generation success digital games entertainment products well formidable motivators possibility using educational settings contemplated research try identify set digital games potential used design learning activities specifically learn computer programming concepts like algorithms variables control structures based contents sequencing learning two games chosen incorporated activities workshop introduction programming order analyze usefulness workshop designed moodle platform using gamification approach present selection serious games focused computer language programming selection criteria two use workshop incoming students well results obtained experience
purpose investigate association unintentional injury mental health australian rural communities methods using cross sectional baseline data longitudinal study randomly selected adults nonmetropolitan australia fitted logistic regression models outcomes domestic public setting injury injury high risk settings using prior depression demographic factors reported also calculated current mental health including psychological distress depressive symptoms risky alcohol consumption comparing injured findings participants completed injury component reported injury requiring treatment doctor hospitalization previous months requiring treatment hospitalization reported injured domestic public setting high risk setting common types mechanisms injury sprains strains falls trips slips respectively preinjury depression independently associated unintentional injury domestic public setting injured setting associated double odds experiencing current depressive symptoms likelihood high risk setting injury significantly associated male gender high risk setting injury associated current psychological distress higher levels alcohol usage conclusions study supports hypothesis pre existing depression associated unintentional injury rural sample indicates important role prior depression management injury given high rate injury rural communities mechanisms prior depression increases likelihood unintentional injury investigated using longitudinal data
background comorbid anxiety symptoms disorders present many psychiatric disorders methodological variations render comparisons frequency intensity difficult furthermore whether risk factors comorbid anxiety symptoms similar patients mood disorders schizophrenia spectrum disorders remains unclear methods overall anxiety severity impairment scale oasis used measure anxiety symptoms psychiatric care patients schizophrenia schizoaffective disorder ssa bipolar disorder depressive disorder helsinki university psychiatric consortium study bivariate correlations multivariate linear regression models used examine associations depressive symptoms neuroticism early psychological trauma distress self efficacy symptoms borderline personality disorder attachment style anxiety symptoms three diagnostic groups results frequent constant anxiety reported ssa patients described severe extreme patients respectively ssa patients significantly less anxious less often avoided anxiety provoking situations patients regression analyses oasis associated high neuroticism symptoms depression borderline personality disorder low self efficacy patients early trauma patients mood disorders conclusions comorbid anxiety symptoms ubiquitous among psychiatric patients mood schizophrenia spectrum disorders almost half reportedly severe anxiety symptoms appear strongly related concurrent depressive symptoms personality characteristics regardless principal diagnosis elsevier masson sas rights reserved
stress reduction interventions linked enhanced well health study examined affect cortisol individuals randomly assigned single minute guided relaxation stress management lecture control group positive affect increased relaxation compared control group dispositional stress reactivity moderating influence individuals high stress reactivity showed highest increases positive affect relaxation results indicate single guided relaxation intervention improves positive affect among individuals high stress reactivity
model independent statistical framework presented interpret data systems mean time derivative positional cross correlation world lines measure spreading quantum geometrical wave function measured precision smaller planck time framework provides general way constrain possible departures perfect independence classical world lines associated planck scale bounds positional information parameterized candidate set possible correlation functions shown consistent known causal structure classical geometry measured apparatus holographic scaling information suggested gravity frequency domain power spectra derived compared interferometer data simple projections sensitivity realistic experimental set ups suggests measurements confirm rule class planck scale departures classical geometry
background recurrent strokes preventable awareness control risk factors hypertension lifestyle changes healthier diets greater physical activity smoking cessation however vascular risk factor control frequently poor among stroke survivors particularly among socio economically disadvantaged blacks latinos people color chronic care model ccm effective framework multi component interventions aimed improving care processes outcomes individuals chronic disease addition community health workers chws played integral role reducing health disparities however effectiveness reducing vascular risk among stroke survivors remains unknown objectives develop test assess economic value ccm based intervention using advanced practice clinician apc chw team improve risk factor control stroke resourced racially ethnically diverse population methods design single blind randomized controlled trial adults years ischemic stroke transient ischemic attack intracerebral hemorrhage within prior days enrolled five sites within los angeles county safety net setting randomized intervention usual care participants excluded speak english spanish cantonese mandarin korean unable consent intervention includes minimum three clinic visits healthcare setting three home visits chronic disease self management program group workshops community venues primary outcome blood pressure control systolic mmhg year secondary outcomes include mean change systolic control vascular risk factors including lipids hemoglobin inflammation reactive protein crp medication adherence lifestyle factors smoking diet physical activity estimated relative reduction risk recurrent stroke myocardial infarction cost effectiveness intervention versus usual care discussion multi component interdisciplinary intervention shown effective improving risk factor control stroke may serve model used internationally reduce race ethnic socioeconomic disparities stroke resource constrained settings
frontal lobe dysfunction known associated impairment social behavior investigated link severe pharmacoresistant frontal lobe epilepsy antisocial trait studied four patients pharmacoresistant epilepsy involving prefrontal cortex presenting abnormal interictal social behavior noninvasive investigations video eeg pet mri intracerebral recording stereoelectroencephalography seeg performed part presurgical assessment comprehensive psychiatric cognitive evaluation performed pre postoperatively frontal lobe epilepsy least years follow patients shared characteristic epilepsy pattern chronic severe prefrontal epilepsy daily seizures epileptogenic zone defined intracerebral recording involving anterior cingulate cortex ventromedial pfc posterior part orbitofrontal cortex early propagation contralateral prefrontal ipsilateral medial temporal structures patients fulfilled diagnostic criteria dsm antisocial personality disorder proved reversible following seizure control pharmacoresistant epilepsy involving prefrontal network associated antisocial personality hypothesize occurrence frequent seizures region prolonged period produces functional damage leading impaired prefrontal control social behavior functional damage reversible since successful epilepsy surgery markedly improved antisocial behavior patients results line previous reports impairment social moral behavior following ventromedial frontal lobe injury elsevier inc rights reserved
sought identify differences health related quality life hrqol among sample hiv positive individuals receiving case management services northern florida study consisted individuals receiving hiv case management included males african americans years old hrqol measured using hiv aids targeted quality life scale hat qol results show significant group differences hrqol race income tobacco use alcohol use drug use cell count despite sample able recall recent count translating findings inform practice hiv care providers need provide continuing education patients disease status knowledge treatment relates self care also hiv care providers especially cognizant impact tobacco alcohol illicit drug use hrqol persons living hiv aids plha working assess social support identify readiness change make appropriate referrals treatment
cardiopulmonary resuscitation cpr life saving medical practice particular characteristics time initiation cpr increase survival cases sudden cardiac arrest main component cpr application external chest compressions unfortunately bystander cpr rates remained low past decade unwillingness attributed various causes among complications discussed paper complications cardiopulmonary resuscitation often occur even doctor skilled acts according guidelines iatrogenic manipulations cpr contain significant violation risk patient physician scope paper review main complications cardiopulmonary resuscitation discussion points characterize ethico legal approach complications ultimate objective prejudice negative defensive medicine doctors avoid application cpr fearing malpractice litigation
bisphenol bpa reported associated adverse health effects including high blood pressure bpa also suspected cross placenta pregnancy might affect children health present study aimed evaluate effect prenatal exposure bpa child age followed children age born women participated midterm pregnancy birth cohort study august july bpa showed nonlinear association constructed piecewise regression model examine association urinary bpa concentration mother around weeks gestation child age determine threshold level bpa association diastolic children positively associated maternal urinary concentration bpa threshold level measured around weeks gestation log unit increment prenatal urinary bpa concentration diastolic increased adjusting potential confounders pulse pressure decreased however systolic significantly associated prenatal bpa concentration present study suggests exposure bpa pregnancy associated higher diastolic children certain threshold creatinine online data supplement
study large size direct shear tests conducted determine interfacial shear characteristics sand geotextile three different normal stresses geotextiles used present study hybrid needlepunched nonwovens containing defined weight proportions jute polypropylene fibers subsequently interfacial shear characteristics hybrid nonwoven geotextile consisting solely polypropylene fibers sand compared analyzed different normal stresses initial higher shear stiffness sand polypropylene geotextiles observed corresponding sand hybrid geotextiles specifically higher normal stresses nevertheless contact efficiency sand hybrid nonwovens similar sand polypropylene geotextiles surface morphology sand particles investigated based images obtained scanning electron microscopy sem quantitatively analyzed means wadell roundness degree angularity methods elsevier ltd rights reserved
study presents new active building block analog signal processing applications namely fully differential current conveyor transconductance amplifier proposed circuit realized using differential difference current conveyors transconductance amplifiers unlike previous building blocks fully differential input electronic tuning capability obtained single new device proposed building block used realize universal biquadratic filter example application pspice simulation results using cmos technology mietec used confirm presented building block simulation results express proposed active building block used realize analog signal processing circuits
background despite suggested link anorexia nervosa autism spectrum disorder asd previous studies used self report diagnostic criteria assess asd populations rather direct observation symptom characteristic asd aim study use standardised clinical assessment asd autism diagnostic observation schedule edition ados investigate presence autistic symptoms cross sectional sample women methods sixty women recruited inpatient day patient specialist eating disorder services participant underwent ados assessment completed set self report questionnaires assessing eating disorder pathology psychiatric symptoms also assessed results fourteen women scored clinical cutoff asd ados eight women displayed repetitive restrictive behaviours difficulties social affect elevated asd symptoms associated increased alexithymia obsessive compulsive symptoms specific eating disorder pathology conclusions asd symptoms represented women severe appear associated psychiatric symptoms warrant investigation consideration treatment
exposed suicide increased risk adverse outcomes including mental illness impaired social functioning fatal non fatal suicidal behavior however unclear many people exposed suicide general community first meta analysis population based studies aimed provide pooled estimates past year lifetime prevalence exposure suicide among family friends peers relationships addition study examined prevalence exposure suicide age group adolescents adults systematic searches literature embase medline psy cinfo identified eighteen studies included analysis pooled past year prevalence life time prevalence past year lifetime prevalences exposure suicide among friends peers significantly higher prevalence exposure within families differences prevalence exposure suicide adolescents adults heterogeneity highly significant future research conducted large national representative samples use standardised assessment instruments given increased risks adverse outcomes among exposed suicide high rate exposure suicide reported important ramifications public health mental health service delivery elsevier ltd rights reserved
background previous studies found ilethr snp melanopsin gene opn functionally associated pupillary light reflex indicates possibility opn ilethr associated non image forming responses aim study therefore determine whether opn ilethr associated sleep wake timing methods total healthy japanese university students participated study scalp hair used genotype ilethr snp opn sleep habits including bedtime wake time sleep duration assessed separately weekdays weekends total samples including samples genotype genotype genotype used statistical analysis significant difference age male female distribution found among three genotype groups results significant difference circadian preference among genotype groups weekdays bedtime wake time midpoint sleep subjects significantly later subjects however difference subjects sleep habits weekends bedtime subjects significantly later subjects midpoint sleep subjects significantly later subjects conclusions findings demonstrated opn ilethr associated sleep wake timing also found sleep wake timing subjects genotype later subjects genotype
study examined associations among head start attendance individualized education programmes ieps parental behaviours child outcomes sample five hundred seventy year old children disabilities home language number disabilities head start enrollment associated iep parents children ieps participated head start used social services social support prevalent parents non head start children ieps children frequent parental book reading greater number books home greater perceived social support among parents associated favourable cognitive social emotional outcomes greater social service use adversely associated reading scores non head start children findings highlight need inclusive iep policies head start programmes parents regarding access special education supports children demonstrate developmental concerns participation head start may buffer negative effects social service use children reading skill development although research needed uncover specific mechanisms responsible association
computer assisted technologies offer new opportunities medical imaging rapid prototyping biomechanical engineering three dimensional modelling soft tissues bones becoming important accuracy analysis modelling processes depends outline tissues derived medical images aim study evaluation accuracy models dog femur derived computed tomography data using point cloud method boundary line method several modelling software solidworks rapidform dsmax software used create models outcomes evaluated statistically accurate prototype dog femur created stereolithography method using rapid prototype device furthermore linearity volumes models investigated software constructed models difference software real models manifests sensitivity software devices used manner
evidence lowered tryptophan activated tryptophan catabolite trycat pathway play role depression somatoform disorder postpartum blues aim study delineate associations trycat pathway premenstrual syndrome pms perinatal depressive physio somatic symptoms examine associations end term serum igm iga responses tryptophan trycats relation zinc reactive protein crp haptoglobin prenatal physio somatic previously known psychosomatic symptoms fatigue back pain muscle pain dyspepsia obstipation prenatal postnatal depression anxiety symptoms measured using edinburgh postnatal depression scale epds hamilton depression rating scale hamd spielberger state anxiety inventory stai included pregnant females without depression non pregnant females significant associations iga igm responses tryptophan trycats prenatal postnatal depression anxiety symptoms except lowered iga responses anthranilic acid prenatal depression large part variance iga responses trycats explained pms haptoglobin positively crp inversely levels iga responses trycats significantly increased pms particular picolinic anthranilic xanthurenic kynurenic acid kynurenine variance physio somatic symptoms end term explained pms previous depressions zinc inversely crp haptoglobin positively igm responses quinolinic acid positively anthranilic acid tryptophan negatively results suggest mucosa derived trycat pathway activation significantly associated pms perinatal depression anxiety symptoms physio somatic symptoms pregnancy immune inflammatory pathophysiology induction trycat pathway appears related physio somatic depression symptoms
cerebral cavernous malformation ccm one common types vascular malformations central nervous system affecting nearly one people ccm lesions characterized grossly dilated vascular channels lined single layer endothelium genetic linkage analyses mapped three ccm loci ccm ccm ccm three causative genes identified allowing new insights ccm pathophysiology focused ccm protein might take place blood vessel formation report expression patterns ccm prenatal development adult human neocortex means immunohistochemistry western blot analysis ccm obviously detected vascular endothelium neuroglial precursor cells development also observed arterial endothelium neurons glial cells adult neocortex expression patterns suggest could one arterial markers whether cause consequence altered vascular identity ccm might play role vasculogenesis angiogenesis human brain development furthermore study ccm described first time developing human neocortex isdn published elsevier ltd rights reserved
small satellites limited payload attitudes sometimes difficult determine limited onboard sensors alone wrong attitudes lead inaccurate map projections measurements require post processing correction study propose automated robust scheme derives satellite attitude observation images known satellite position matching land features observed image well registered base map images scheme combines computer vision algorithms feature detection robust optimization geometrical constraints satellite observation applying proposed method uniform observations class small satellite satellite attitudes determined accuracy degrees comparable star trackers satellite position accurately determined map projected images generated based accurate attitudes errors satellite position add systematic errors derived attitudes proposed scheme focuses determining satellite attitude feature detection algorithms applying raw satellite images unlike image registration studies register already map projected images delivering accurate attitude determination map projection proposed method improve image geometries small satellites thus reveal fine scale information earth
prototyping plays various roles software engineering function exploratory way order gather requirements generate artifact iterative cycles development leads final delivery product system according literature beaudouin lafon mackay prototyping tools techniques human computer interaction handbook fundamentals crc press lim stolterman tenenberg anatomy prototypes prototypes filters prototypes manifestations design ideas acm transactions computer human interaction tochi prototype described incomplete flexible communication tool design idea manifesting filtering interesting aspects original idea basis propose peircean definition tool prototype considered complex set signs better text features literally stands corresponding features final artifact foreseeing particular aspects overall capacity outcome happens stakeholders involved project little competence tools technologies discussed correctly interpret prototype answer question propose discourse analysis duranti linguistic anthropology cambridge mass cambridge university press potter discourse analysis way analyzing naturally occurring talk qualitative research theory method practice edited silverman sage schegloff harvey sacks lectures conversation introduction memoir human studies design session elders daily centre frail adults rome context could observe interactions material aspect prototype product intended meaning significance produce distortions form aberrant interpretations even complete lack comprehension communication breakdown prototypes lose connection features behaviors product relation representamen interpretant lost
paper proposes stability guaranteed bias compensated normalized least mean square nlms algorithm noisy inputs bias compensated algorithms require estimated input noise variance elimination process bias caused noisy inputs however conventional methods estimating input noise variance algorithms might cause instability specific situation paper first analyzes stability nlms algorithm investigating dynamics mean deviation mean square deviation nlms algorithm based analysis estimation input noise variance adjustment step size carried perform stabilization well performance enhancement terms steady state error convergence rate simulations system identification acoustic echo cancellation scenarios noisy inputs show proposed algorithm outperforms existing bias compensated algorithms aspect stability steady state error convergence rate
home gardening extremely important resource poor households limited access production inputs however south africa attempts implement home garden programmes often fail improve food security poor due water scarcity rainwater harvesting technology rwht used supplement conventional water supply systems potential fully exploited understanding factors influencing adoption improved technologies therefore critical successful implementation agricultural development programmes study evaluated determinants farmers decisions adopt rainwater harvesting technology rwht rural msinga kwazulu natal province south africa using binary logistic regression model based household survey rural home gardeners result logistic regression model showed gender age education income social capital contact extension agent perception attitude towards rwht statistically significant explaining farmers adoption rwht study area implications agricultural rural development policy discussed
power systems increasing flexibility requirements increasingly relying gas turbines follow net load gas network support unforecast changes gas turbine generation addition role gas network supplying fuel heating sector means alternative heating scenarios impact gas network ability provide flexibility light paper presents novel methodology assessment impact heating integrated flexibility gas electrical transmission networks model considers transport requirements gas heating sector well regional distribution gas within gas network context zonal linepack distribution electrical network modelling conducted using opf gas network flexibility assessed using novel iterative steady state gas flow methodology case studies performed british networks highlight energy systems large heat based gas demand extreme cold days reduce flexibility gas network milder days use gas turbines supplying electrified heating sector lead increase linepack swing
peroxisomes indispensable organelles lipid metabolism humans biogenesis assumed regulation peroxisome proliferator activated receptors ppars however recent studies hepatocytes suggest mitochondrial proliferator pgc alpha peroxisome proliferator activated receptor gamma coactivator alpha also acts upstream transcriptional regulator enhancing peroxisomal abundance associated activity unknown whether regulatory mechanism enhancing peroxisomal function node mitochondrial biogenesis human skeletal muscle hskm whether fatty acid oxidation fao affected primary myotubes vastus lateralis biopsies lean donors bmi exposed adenovirus encoding human pgc alpha gfp control peroxisomal biogenesis proteins peroxins genes pexs responsible proliferation functions assessed western blotting real time qrt pcr respectively palmitic acid lignoceric acid exclusive peroxisomal specific substrate used assess mitochondrial oxidation peroxisomal derived metabolites overexpression pgc alpha peroxisomal membrane protein kda pmp pex mitochondrial citrate synthetase protein content significantly elevated pgc alpha pmp key pexs peroxisomal beta oxidation mrna expression levels significantly upregulated concomitant increase lignoceric acid oxidation peroxisomal mitochondrial activity observed novel findings demonstrate addition proliferative effect mitochondria pgc alpha induce peroxisomal activity accompanying elevations long chain longchain fatty acid oxidation peroxisomal mitochondrial functional cooperation observed hskm cells
observe effects huannao yicong formula hyf learning memory regulating effect gamma secretase related anterior pharynx defective aph presenilin enhancer pen signaling pathway discuss clarify mechanism hyf alzheimer disease sixty app transgenic mice randomly allocated groups model group donepezil group hyf low dose group hyf hyf high dose group hyf group another cbl mice age genetic background allocated control group proper dosage drugs distilled water given intragastric administration daily weeks weeks administration learning memory abilities mice group evaluated morris water maze test amyloid precursor protein app beta beta levels hippocampus detected enzyme linked immunosorbent assay gamma secretase detected dual luciferase assaying levels aph hypoxia inducible factor alpha hif alpha camp response element binding protein creb pen mrna expression measured western blot real time polymerase chain reaction hyf ameliorate learning memory deficits app transgenic mice decreasing escape latency improving number platform crossing swimming speed hyf decrease levels app beta beta activity gamma secretase hippocampus alzheimer disease model mice hyf regulate levels creb pen expression mrna hyf improve learning memory ability inhibiting activity gamma secretase creb pen signaling pathway may one therapeutic mechanisms hyf alzheimer disease
experimental investigation carried generate mechanical behavior normal concrete cores strength range mpa including compressive strength elastic modulus strain peak stress stress strain relationships several formulations concrete study observed conservative estimation elastic modulus strain peak stress obtained value compressive strength accuracy predictions number analytical models available literature discussed paper shows development statistical damage mechanics model concrete uniaxial loading compression ultimate failure model formulated using weibull statistical theory strength materials body heterogeneous concrete material simulated continuum comprising large population microscopic weakestlink elements model provides good prediction experimental results study compared existing models gave better prediction elsevier ltd rights reserved
transition parenthood watershed moment parents introducing possibility intra individual interpersonal growth decline given increasing number dual earner couples united states new parents attitudes towards employment well ways balance employment personal demands may impact overall well based anecdotal accounts guilt conflict employment family termed work family guilt appears particularly pervasive among mothers young children specifically mothers fathers express high levels subtype work family guilt pertains negative impact work families termed work interfering family guilt however little research within psychology explicitly examined phenomenon knowledge quantitative study investigated gender differences work family guilt among parents young children cross sectional correlational study involving parents toddlers greater southern california area coded parents narrative responses series open ended questions regarding employment family presence work family guilt work interfering family guilt form guilt negative impact employment children mothers significantly higher work family guilt work interfering family guilt relative fathers discuss findings terms theory gender roles well questions generate future areas investigation
developed calibration target use fluid immersed endoscopes within context gift surg guided instrumentation fetal therapy surgery project one aims project engineer novel real time image processing methods intra operative use treatment congenital birth defects spina bifida twin twin transfusion syndrome developed target allows sterility preserving optical distortion calibration endoscopes within minutes good optical distortion calibration compensation important mitigating undesirable effects like radial distortions hamper accurate imaging using existing endoscopic technology fetal surgery also make acquired images less suitable potentially useful image computing applications like real time mosaicing paper proposes novel fabrication method create affordable sterilizable calibration target suitable use clinical setup method involves etching calibration pattern laser cutting sandblasted stainless steel sheet target validated using camera calibration module provided opencv state art software library popular computer vision community
optical absorption semiconducting agbr nanocubes significantly increased times measured spectral range bonded surface dielectric sio nanospheres electrostatic interaction absorption enhancement factor depends wavelength size sio nanoparticles nps finite difference time domain calculations provide nearfield intensity mapping heterostructure composed agbr nanocube close contact sio nanosphere electric field distributions indicate field enhancement near sio agbr interface due light scattering absorption enhancement agbr nanocube implying enhanced scattering nearfield increases absorption cross section agbr nanocube absorption cross section spectra calculated using mie theory agree experimental observations discovery sheds light utilization dielectric spherical particles increase absorption semiconductor nps thus improving light harvesting efficiency solar energy conversion
textile industry largest manufacturing industry pakistan good reputation global supply chains organizations want achieve excellence optimally utilizing human capital socio technical complexity working systems along high level expectations workplace stress management become area deep concern textile sector exception highly important address stress related issues organizations capitalize benefits related human resource ensuring well levels people involved management expected vulnerable stress critical role organizations objective study identify causes workplace stress among managers textile industry cross sectional study data questionnaire collected managers different areas textile sector like spinning weaving apparel manufacturing exploratory factor analysis carried factors like physical agents work training development support work family work interface work environment role found major causes workplace stress
energy efficient medical equipment design current research trend medical science scientists shifting focus toward energy efficient medical equipment design ecg machine commonly used medical equipment medical equipment consuming less power traditional counterpart whole medical system greener energy efficient finally reduces cost medical treatment work going design implement energy efficient ecg machine using lvdci low voltage digitally control impedance sstl stub series terminated logic hstl high speed transistor logic standard
circuit generated noise limits analog signal processing measure circuit ability maintain signal integrity given circuit signal noise ratio find quantity must first find equivalent noise signal input generated circuit paper presents direct systematic method finding complete input equivalent noise signal use driving point impedance signal flow graph methodology approach noise signal translated unambiguously origin node input without use approximations distinctions active device types bipolar mos limited device models used
person identification receives increasing attentions computer vision due potential applications video surveillance order alleviate wrong matches caused misalignment missing features among cameras propose learn multi view gallery frequently appearing objects relatively closed environment gallery contains appearance models objects different cameras viewpoints strength learned appearance models lies invariant viewpoint illumination changes automatically estimate number frequently appearing objects environment update appearance models online propose dynamic gallery learning algorithm specifically build two datasets validate effectiveness approach realistic scenarios comparisons benchmark methods demonstrate promising performance accuracy efficiency identification
attribute based signature abs schemes play vital role accomplish authentication signer privacy simultaneously recent years cryptographic primitives deployed insecure devices mobile devices thereby secret key exposure seems inevitable alleviate impact key exposure abs scenarios authors apply method key insulation abs construct first signature policy attribute based key insulated signature abkis scheme proposed construction supports expressive monotone boolean functions signing predicates preserves signer privacy abkis scheme key insulated strong key insulated secure computational diffie hellman exponent assumption best knowledge proposed abkis first abs scheme signature policy flavour dealing key exposure problems employing key insulation mechanism
basal marker expression triple negative breast cancers identifies basal like tumours thus separates group two prognostic groups however expression prognostic significance basal markers luminal breast cancers poorly described aim study investigate expression prognostic value basal markers egfr luminal breast cancer total formalin fixed paraffin embedded breast cancer tumours well characterized cohort norwegian women previously reclassified molecular subtypes using ihc ish included study present study tumours expressing least one basal markers egfr defined basal marker positive cumulative incidence death breast cancer hazard ratio analyses used assess prognosis according basal marker expression total cases basal marker positive higher proportion basal marker positive tumours histopathological grade compared basal marker negative hormone receptor positive negative cases found better prognosis basal marker positive breast cancer compared basal marker negative subtypes combined poorer prognosis basal marker negative cases found histopathological grade tumours among grade
paper presents novel predictive digital control method boundary conduction mode pfc converters without need detecting inductor current proposed method inductor current predicted analytical equations instead detected sensing resistor predicted zero crossing point inductor current determined values input voltage output voltage predicted inductor current importantly prediction zero crossing point achieved single switching cycle therefore errors predictive calculation caused parameter variations compensated prediction zero crossing point proposed method shown good accuracy proposed method also shows high stability towards variations inductance output power experimental results demonstrate effectiveness proposed predictive digital control method pfc converters
embryos extend anterior posterior axis conserved process known axis elongation drosophila axis elongation occurs epithelial monolayer germband driven cell intercalation cell shape changes oriented cell divisions posterior germband anterior germband cells also divide axis elongation developed image analysis pattern recognition methods track dividing cells confocal microscopy movies generally applicable approach mesectoderm cells forming ventral midline divided parallel axis lateral cells displayed uniform distribution division orientations mesectoderm cells intercalate sustained increased strain cell division division mesectoderm cell density increased along axis thus relieving strain used laser ablation isolate mesectoderm cells influence tissues uncoupling mesectoderm intercalating cells affect cell division orientation conversely separating mesectoderm anterior posterior poles embryo resulted uniformly oriented divisions data suggest mesectoderm cells align division angle reduce strain caused mechanical forces along axis embryo
linked lists play important role learning basic computer science concepts among number different data structures basis complex data structures tree data structures recursion stacks queues effectively implemented using linked lists observe years students struggle linked lists data structures students understand concepts stack queue data structures faster need time understand visualize linked list operation algorithms paper presents game like instructional module called space traveler aims assist students better understand master concepts linked lists four undergraduate students developed using gamemaker studio three months space traveler game looks like classic snake game game supports practicing linked list operations insertion search deletion paper presents game design implementation detail shares experiences using module csc data structure class winston salem state university wssu module refined based feedback students instructors refined version used upcoming semesters pretest posttest survey developed used evaluation process addition lab assignment designed accompany game module initial assessment outcomes showed promising student improvements result use game module classroom module made available online benefit students institutions
mammalian striatum controls sensorimotor psychoaffective functions coordinated activities two striatonigral striatopallidal output pathways show retinoic acid receptor beta rar beta controls development subpopulation gabaergic gad positive striatonigral projection neurons rarb knock mice concomitant reduction gad dopamine receptor drd substance expression different phases prenatal development associated reduced number drd positive cells birth contrast normal numbers striatopallidal projection neurons expressing dopamine receptor fate mapping using brdu pulse chase experiments revealed deficits may originate compromised proliferation late born striosomal neurons lead decreased number drd positive cells retaining brdu postnatal day rarb striatum reduced expression fgf subventricular zone lateral ganglionic eminence lge embryonic day may underlie deficits inducing premature differentiation neuronal progenitors illustrated reduced expression proneural gene ascl mash increased expression meis marker postmitotic lge neurons agreement critical role fgf control reduced number ascl expressing neural progenitors concomitant increase meis expressing cells observed primary cell cultures rarb lge defect normalized addition fibroblast growth factor fgf data point role meis striatal development also supported reduced neuronal differentiation lge meis embryos data unveil novel mechanism development striatonigral projection neurons involving retinoic acid fgf two signals required positioning boundaries meis expressing cells
purpose within construction procurement transaction cost economics offers mechanism understand unseen costs associated pre post contract work pre contract include costs related information gathering procurement post contract include activities contract administration enforcement purpose paper estimate magnitude transaction costs tcs different procurement systems used construction projects new zealand specifically estimating relative values tcs traditional design build delivery systems purpose comparison design methodology approach study develops conceptual model relationship procurement systems model operationalized developed questionnaire cross sectional sample approach deployed involving pilot survey questionnaires results verification real world cases data sought construction professionals management design operations project managers architects engineers quantity surveyors procurement officers tcs measured using time spent conducting procurement related activities surrogate cost professionals evaluate time spent procurement activities using likert scale comparing traditional design build delivery systems data triangulated real world cases test explain developed model test included validity reliability path analysis regression analysis factor analysis structural equation modelling sem primary analytical technique used sem yield information goodness fit model development comparison confirmatory strategies spss amos statistical software used data analysis model development findings results suggest procurement systems indirect impact tcs relationship procurement systemand tcs fully mediated costs information procurement administration enforcement applying developed models traditional design build real world cases found tcs traditional system amounts percent annual salary cost project manager indicator quantum design build system amounts percent annual salary cost project manager tcs calculated using regression equations based factor loadings traditional design build models practical implications study applies new theoretical model link procurement system tcs investigating empirically demonstrating influence procurement system tcs construction also offers new plausible explanation factors influencing tcs procurement study emphasizes house tcs perspective professionals findings practical implications construction business practice due robust empirical nature theoretical framework might enhance performance construction industry originality value study contributes procurement selection construction introducing new conceptual model link procurement system tcs extended current practices procurement selection estimating tcs traditional design build systems comparison
method shape finding specific type self anchored suspension bridge whose main cable three dimensionally curved proposed study method referred coordinate iteration method cim developed force equilibrium features rational arch axis suspension cables modeled truss cable elements establishing linear iterative equations terms unknown coordinates updating relation matrices iteratively trial profile three dimensional cable system easily stably converges target system cim extended shape finding total bridge system aid specific numerical model proposed study referred indiscrimination coordinate rod model icrm model used simulate core deformation effects total bridge detailed procedure undertaken establish finite element model equilibrium system finished dead load state based cim icrm also presented precision efficiency method demonstrated actual numerical examples american society civil engineers
studies global software engineering gse teams found informal non work related conversations positively associated trust seeking use novel analytical techniques carefully investigate phenomenon described non work related conversations adapting economics literature concept cheap talk studied using evolutionary game theory egt specifically modified classic stag hunt game analyzed dynamics fixed population setting abstraction gse team able demonstrate cheap talk internet cheap talk powerful enough facilitate emergence trust improve probability cooperation punishment uncooperative behavior comparable cost cheap talk validate results theoretical approach conducted two empirical case studies analyzed logged irc development discussions apache lucene chromium using quantitative qualitative methods results provide general support theoretical propositions discuss findings theoretical practical implications gse collaborations research
acting focus network security field intrusion detection technology idt plays important role different conditions feature selection methods intrusion detection directly affect efficiency intrusion detect system paper feature selection algorithm based relief relief sequential backward search relief sbs proposed considering statistical correlation relief relief sbs improved algorithm eliminates feature round iteration adopts result relief algorithm assessment criteria feature simulation results show proposed feature selection algorithm improves efficiency intrusion detection moreover provides correlation technique support idt
based design principle alternating current electromagnetic circuit paper presents design novel low frequency high power miniaturisation giant magnetostrictive actuator gma khz using terfenol rod smart composite material developed noise reduction underwater target finite element method adopted simulate optimise design smart material structure simulated resonance frequencies giant magnetostrictive materials gmm found consistent measured values experiments carried water tube gmm active acoustic absorption material active acoustic control system research results show giant magnetostrictive composite smart materials active sound absorption materials effective light weight low frequency broadband
current therapeutic approaches alzheimer disease symptomatic modest efficacy available effective cure prevention hence need arise search neuroprotective agents combat current study aimed investigating neuroprotective effect nanodiamond adamantine based nanoparticles aluminum induced cognitive impairment rats experimental model induced aluminum chloride weeks confirmed morris water maze maze behavioral tests biochemical histological analyses hippocampus also performed aluminum treated rats showed behavioral biochemical histological changes similar associated improved learning memory reversed histological alterations molecular levels mitigated increase hippocampal beta amyloid beta beta site amyloid precursor protein cleaving enzyme bace together regulation phosphorylated tau protein also modulated excitatory glutamate neurotransmitter level furthermore boosted brain derived neurotrophic factor bdnf mitochondrial transcription factor tfam suppressed proinflammatory cytokine tumor necrosis factor alpha tnf alpha interleukin curbed oxidative stress hampering inducible nitric oxide synthase inos moreover augmented hippocampal levels phosphorylated signal transducer activator transcription stat cell leukemia lymphoma bcl anti apoptotic protein diminished nuclear factor kappab kappa caspase casp expression findings indicate protective effect memory deficits like pathological aberrations probably via modulating stat signaling effects mediated likely modulating methyl aspartate nmda receptors
background hepatitis hbv hcv important causes morbidity mortality people living human immunodeficiency virus hiv burden infections sub saharan africa still unclear estimated prevalence hepatitis surface antigen hbsag hepatitis antibody hcvab among hiv infected individuals rwanda identified factors associated infection methods january june performed systematic screening hbsag hcvab among hiv positive individuals enrolled public private hiv facilities across rwanda results analyzed determine marker prevalence variability demographic factors results overall among individuals tested prevalence hbsag hcvab confidence interval respectively hiv individuals infected hbsag hcvab prevalence higher males hbsag hcvab increased age hcvab prevalence significantly higher people aged years prevalence varied geographically conclusion hbv hcv infections common among hiv infected individuals rwanda important viral hepatitis prevention treatment activities scaled control transmission reduce burden population particular efforts made conduct targeted screening males older population assessment required determine rates hbv hcv chronicity among hiv infected individuals identify effective strategies link individuals care treatment
interpersonal dysfunction central borderline personality disorder bpd recent research focused role oxytocin bpd mixed results regarding processing social information fifteen bpd patients controls participated two clinical interviews one one placebo randomly conducted week apart double blind fashion nonverbal behavior evaluated using ethological coding system interviews childhood trauma examined using childhood trauma questionnaire patients bpd showed less affiliative behavior controls notably controls patients displayed affiliation given compared given also associated less flight behavior groups given compared placebo responses unrelated patients history childhood trauma present findings informative respect patients nonverbal prosocial behavior clinical settings
well known edge vector space oriented graph decomposed terms cycles cocycles alias cuts bonds basis cycle cocycle spaces generated adding removing edges arbitrarily chosen spanning tree paper show edge vector space also decomposed terms cycles generating edges cocycles called cochords cocycles generating edges cycles called chords observation follows construction terms oblique complementary projection operators employ algebraic construction prove several properties unweighted kirchhoff symanzik matrices encoding mutual superposition cycles cocycles particular prove dual matrices planar graphs spectrum multiplicities briefly comment construction provides refined formalization kirchhoff mesh analysis electrical circuits lately applied generic thermodynamic networks
attack graphs model possible paths potential attacker use intrude target network used determining proactive reactive security measures attack graph generation process includes vulnerability information processing collecting network topology application information determining reachability conditions among network hosts applying core graph building algorithm article introduces classification scheme systematical study methods applied phase attack graph generation process including usage attack graphs network security related works literature stated based proposed classification scheme contributive ideas potential challenges open issues attack graph generation usage provided elsevier ltd rights reserved
paper proposes protection method single line ground slg faults ungrounded offshore wind farm fully rated converter based wind turbines proposed method uses unsynchronized current phasors measured unit protections installed connection point fully rated converter frc based wind turbines wts unit protection collects unsynchronized current phasors two adjacent nodes synchronizes aligning positive sequence current phase angle faulted section identified comparing phase angles synchronized zero sequence currents adjacent nodes simulations ungrounded offshore wind farm relay models carried using power system computer aided design pscad electromagnetic transients including direct current emtdc
new task force postmortem imaging established annual meeting european society paediatric radiology espr graz austria postmortem task force separate child abuse task force covers aspects fetal neonatal non forensic postmortem imaging main focus task force guidance standardization non radiographic postmortem imaging particularly postmortem postmortem mri manuscript outlines starting point task force mission statement outline current experience short long term goals
requirement household heat metering variable flow heating network future trend difficult heating according users demand hydraulic disorder caused mainly individual user regulation self operated pressure difference control valve spdcv widely used heating system solve problem paper concentrates effect users flow reduction non regulated users flow constant pressure difference heating network cpdhn constant pressure difference end user cpde change pressure diagram equal pressure drop parallel user based kirchhoff voltage law used theoretical model influencing law users regulation obtained results follow user pressure drop larger design pressure drop cpdhn less design pressure drop cpde user flow reduced front non regulated users flow increased little middle ones take second place back non regulated users flow increased greatly user flow reduced cpdhn front non regulated users flow reduced greatly middle ones take second place back non regulated users flow keep constant user flow reduced cpde conclusion got cpdhn better cpde user flow reduction
recent experiments demonstrated fundamental mechanism electrospinning process rapid whipping electrically charged liquid jet article focuses mathematical modeling whipping also called bending instability electrically charged liquid jet created polymer solution electrospinning ideal rectilinear segment electrically charged jet called viscoelastic dumbbell key attribute mathematical model presented herein formulated governing equations used describe physical properties dynamics segment three dimensional cartesian coordinate system developed multi threaded computer application allows simulate electrospinning process application algorithmization numerical discretization using three dimensional computer graphics able visualize results computer simulations paths jet well depositions electrospun nanofiber theoretical results agreement previously published laboratory experiments elsevier inc rights reserved
background codes ethics coe widely adopted several professional areas including software engineering however contemporary coe pay sufficient attention one important trends appeared last years environmental issues aim aim study establish green coe software engineering professional practices greco intention cover wide range aspects related sustainability economic environmental social technical features additionally interested encouraging software engineers adopt aspects methods green coe presented result interaction several experts area first version greco whose starting point discussion ginseng workshop created identifying key principles adapting green area next various important coe reviewed gather existing references sustainability detect new ones elements would possibly incorporated new code stimulate creation new sustainable principles results final result greco code produced modifying existing principles introduction new ones
wireless sensor networks wsns widely used different fields battle field environment monitoring intrusion detection amount nodes deployed many factors make sensor nodes vulnerable attacked compromised order address issue many different schemes methods proposed trust evaluation trust management play important role detecting malicious nodes paper propose trust management system clustered wsns monitoring sensor nodes behaviors evaluating trust values system employs hash algorithm generating identify labels sensor nodes distinguish external attackers normal nodes dynamically manages trust value node detect compromised nodes based trust evaluating model based beta density function simulation results show scheme detect malicious nodes quickly prevents clustered wsns external attacks internal compromised nodes attacks copyright john wiley sons ltd
background knee dislocations often require multiple concurrent ligament reconstructions involve creating several tunnels distal femur therefore risk tunnel convergence increased limited bone volume within distal aspect femur purpose assess risk tunnel convergence determine optimal reconstruction tunnel orientations multiple ligament reconstructions femur study design descriptive laboratory study methods three dimensional knee models developed computed tomography scans patients medical image processing software used create tunnels primary ligamentous structures replicating surgical approach would used multiple ligament reconstructions thereafter tunnel orientation varied surgically relevant directions determine orientations minimized risk tunnel convergence orientation anterior cruciate ligament acl posterior cruciate ligament pcl tunnels held constant throughout study orientation fibular collateral ligament fcl popliteus tendon plt superficial medial collateral ligament smcl posterior oblique ligament pol tunnels varied avoid convergence results high risk tunnel convergence observed fcl acl tunnels fcl tunnel aimed degrees axial coronal planes aiming fcl tunnel degrees anteriorly minimized convergence acl tunnel tunnel convergence observed plt tunnel aimed degrees anteriorly parallel fcl tunnel avoid convergence smcl pcl tunnels smcl tunnels aimed degrees proximally coronal plane degrees degrees anteriorly concomitant pol reconstruction smcl aimed degrees proximally anteriorly pol degrees proximally anteriorly plt pol tunnels aimed degrees coronal axial planes increased risk violating intercondylar notch conclusion femoral tunnel orientations multiple ligament reconstructions need adjusted avoid tunnel convergence lateral side aiming fcl plt tunnels degrees anteriorly eliminated convergence acl tunnel medial side tunnel convergence avoided orienting smcl tunnel degrees proximally anteriorly pol tunnel degrees proximally anteriorly pol plt tunnels aimed degrees axial plane increased risk violating intercondylar notch clinical relevance risk tunnel convergence acl pcl femoral tunnels reduced adjusting orientation fcl plt tunnels smcl pol tunnels respectively
review focuses fundamental fluid mechanics governs generation micro nanospheres micro nanosphere generation process gathered significant attention past two decades since micro nanospheres widely used drug delivery food science cosmetics application areas many methods developed based different operating principles microfluidic methods electrospray methods chemical methods forth paper focuses microfluidic methods although structure microfluidic devices may different operating principles behind often similar following initial discussion fluid mechanics related generation microspheres various design approaches discussed including junction flow focusing membrane emulsification modified junction double emulsification methods advantages problems associated method also discussed next commonly used computational fluid dynamics cfd methods reviewed three different levels microscopic mesoscopic macroscopic finally issues identified current literature discussed suggestions offered regarding future direction technology development related micro nanosphere generation relevant patents topic reviewed cited
submicron sized nafepo successfully prepared situ electrochemical delithiation olivine type lifepo subsequent sodium insertion aprotic electrolyte composition dependence gibbs energy entropy sodiation investigated temperature dependent measurements equilibrium potential exchange current density sodium ion diffusion coefficient nafepo systematically investigated function composition significant state charge dependencies kinetic thermodynamic parameters found correlate phase transformations active material charging discharging results confirm existence path dependence related asymmetric phase transformation behavior recently proposed literature elsevier ltd rights reserved
quest meet ever increasing demand energy coupled need curtail emission led deployment renewable energy sources electrical network past decades development although desirable comes known downside fluctuating production especially dealing wind solar power sources introduces variations voltage frequency along harmonic pollution need constantly controlled system operators required balance demand supply sometimes forced cut supply renewable energy sources order maintain network stability resulting losses paper shows approach sizing renewable energy plant storage system using particle swarm optimization background aim support hosting capacity network unit connected
last years seen identification pharmacologic approaches target bromodomain extraterminal bet proteins cancer treatment proteins essential role gene transcription regulation binding acetylated lysine residues histone tails activating gene transcription bet inhibitors tested preclinical models including pediatric malignancies several adult clinical trials ongoing since development new drugs pediatric cancer long lagged behind programs adults aim review show importance therapies pediatric malignancies support development pediatric oncology hematology
hybrid structure consisting iron oxide nanoparticles decorated titania tio nanotube arrays synthesized rapid forced hydrolysis method followed post annealing treatment morphology structure analysis hybrid tio feo composites indicated uniform conformal coating hematite nanoparticles anatase titania nanotubes diffuse reflectance spectroscopy used investigate absorption properties tio feo structures increase absorbance visible light range observed compared pristine nanotubes similar visible light absorbance enhancement observed dye sensitized titania nanotubes thus iron oxide decorated titania nanotube demonstrate immense potential use inexpensive robust materials improved solar energy harvesting photovoltaic applications
following steps integrated water management iwm approach european union brazil moved top approach water management participatory one involves different segments society since decisions regarding water affect economic activities environment life communities important society takes active part opportunities discuss collectively decide water issues done multiple perspectives taken consideration sustainability water management planning likely maintained nevertheless many conflicts arise society share water limited resource multiple uses volume water needed way used certain activities agriculture industry negatively impact availability quality uses paper proposes integrative negotiation model assist watershed committees wscs deal conflicts regarding water pollution pre negotiation phase decision makers dms use strategic options development analysis soda method structure problem identify relevant factors decision problem dms evaluate problem multi attribute perspective additionally post negotiation phase proposed evaluation criteria monitor compromise solution chosen affecting quality water actors fulfilling parts agreement virtual case study presented illustrate applicability model three dms considered part wsc namely representative civil society representative public sector representative water users wsc used social economic environmental attributes evaluate proposals counter proposals arrived balanced agreement taking consideration interests model helps reduce conflicts dms flexible sense applied different conflicts contexts also easy implement wscs elsevier ltd rights reserved
context cancer challenging experience evidence psychosocial interventions effective improving adjustment following treatment cancer center cancer survivors breast prostate blood cancers completed four session cognitive behavioral stress program first session delivered survivor local cancer center provided loaner tablet three subsequent sessions delivered group based videoconference tablet session content supplemented tailored ebook designed specifically program participants provided feedback program well standardized measure perceived stress issues despite evidence psychosocial programs effective significant barriers dissemination particularly residing rural areas live near academic medical centers programming readily available experiences delivering group based videoconference program cancer survivors described including positives challenges associated design implementation lessons learned study participants enrolled across four different states majority reported least minute commute cancer center travel burden played meaningful role desire participate videoconference based program although participants reported session content well suited addressing stress management concerns session facilitators able effectively teach program techniques progressive muscle relaxation cognitive reframing program helpful overall modest improvements perceived stress seen participants noted challenges delivery including feeling disconnected others difficulty focusing technical problems desire longer program thus although novel delivery group based psychosocial program using tablet videoconference feasible survivorship program desired cancer survivors key improvements must made future efforts enthusiasm potential telehealth must tempered reality delivery present challenges interfere intervention implementation efficacy facilitators must proactively address technological interpersonal challenges associated use group based videoconference order improve ability positively impact cancer survivors many issues resolved prior program launch require foresight planning part program team
uterine leiomyomata benign monoclonal tumors arising smooth muscle cells belong one common pathologies female genital system current pharmacotherapies oral contraceptives progestins gnrh analogs ineffective limited use long term treatment although still much debate regarding etiology likely progesterone progesterone receptor play key role development profound importance progesterone female reproductive system led discovery synthetic progesterone receptor ligands poses activity ranging pure agonist activity trough mixed agonist antagonist activity pure antagonist activity development selective progesterone receptor modulators sprm created new therapeutic options great potential number gynecologic indications far ulipristal acetate approved emergency contraception mifepristone progesterone receptor antagonist unique property compound termination pregnancy recently european commission authorized ulipristal acetate pre operative treatment uterine fibroids superior efficacy ulipristal acetate versus placebo reduce excessive uterine bleeding reduce total fibroid volume prior surgery demonstrated moreover non inferior efficacy ulipristal acetate versus gonadotropin releasing hormone gnrh agonist reduce excessive uterine bleeding prior surgery uterine fibroids documented ulipristal acetate also characterized superior side effect profile comparison leuprolide acetate terms serum estradiol levels proportion patients moderate severe hot flashes treatment regarding safety profile except elevation liver enzymes telapristone onapristone treatment date serious untoward effects sprm reported issue endometrial effects compounds remains resolved although observation intrinsic agonist activity sprm prevents endometrial proliferation may suggest future use agents prevention endometrial hyperplasia promising applications including endometriosis endometrial cancel cushing disease alzheimer disease long term contraception currently development
full potential plastic gear usage limited poor mechanical properties also equally poor temperature limits poor heat conduction properties cooling holes developed decrease amount thermal damage contact surface cooling holes promote increased stress tooth deflection thus exerting negative effect article compares various cooling holes plastic gear configurations proposes novel cooling holes thermal mechanical simulations consider specific aspects plastic gear meshing performed main objective article verify best methods reducing thermal damage cooling holes results indicate best compromise temperature reduction mechanical properties new tooth geometry results also indicate simple variations cooling holes proposed improve tooth performance
focusing case jarso girhi eastern ethiopia article seeks contribute comparative studies social territorial relational effects effort political administrative decentralization multi ethnic settings article analyses political social implications elements constitute impediments social cohesion socio economic interaction study area data required study collected fieldwork involved interviews focus group discussions field observations basis analysis article recommends done create relational politics place places spaces connect people remain open discontinuous relational internally diverse
moment birth human builds microbe host symbiosis key preservation health well personal symbiotic coexistence result progressive enrichments microorganism diversity external supplies diversity nowadays massively overthrown drastic changes related clinical practice birth management environmental exposure nutrition healthcare behaviors last two generations frame massive modifications life food habits people sedentary overfed permeated drugs pollutants able measure impact changes gut microbiota diversity concomitantly modifications lifestyle associated dramatic increase incidence immune mediated diseases including metabolic allergic inflammatory diseases likely neurodegenerative psychiatric disorders microbiota becoming hot topic scientific community mainstream media number scientific publications increased factor three last five years gastrointestinal metabolic diseases productive areas intellectual property landscape patent families microbiota doubled meantime parallel funding either national institutes nih funds research mainly field allergies infections cancer cardiovascular diseases white house launched national microbiome initiative pharmaceutical companies follow trend showing boost strong support research field microbiota major health players investing microbiome research shown number deals signed funding glens round table addressed medicine tomorrow considering human beings human microbe symbiotic supraorganism could leverage microbiome knowledge tools rationale working group structured around four domains innovation could derive ongoing efforts deciphering interactions human cells intestinal microbiome central component human health namely development stratification monitoring tools identification new target drug discovery part supra genome exploitation microbiota therapeutic target modulated finally source live biotherapeutics adjuvants four streams exemplify microbiota changed way consider wide range chronic incurable diseases consequences long lasting dysbiosis depth micro biota analysis opening one broadest fields investigation improving human animal health source major therapeutic innovations tackling today medical unmet needs thus propose range recommendations basic researchers care givers welt health authorities gain reliability microbiome analysis accelerate discovery processes translation applications benefits people finally les ateliers glens round table microbiota benefited richness french ecosystem france represents center excellence microbiota research field french institutions institut national recherche agronomique inra metagenopolis micalis centre national recherche scientifique cnrs unite recherche sur les maladies infectieuses tropicales emergentes urmite institut cardiometabolism nutrition ican institut des maladies metaboliques cardiovasculaires imc institut national sante recherche medicate inserm pasteur institute gustave roussy top players number publications published elsevier masson sas behalf societe francaise pharmacologie therapeutique
case kendra year old girl autism spectrum disorder asd presents follow feeding problems pediatric clinician child family parents scientists feeding concerns date infancy diagnosed gastroesophageal reflux disease gerd associated persistent bottle refusal acceptance pureed foods months milk peanut allergies diagnosed following feeding clinic evaluation months prescribed soy milk supplement blocker concern oral motor dysfunction also referred early intervention feeding therapy however parents terminated participation months became anxious tantrum prior treatment groups seen another feeding program years zinc folate thyroid celiac panel normal endoscopy negative eosinophilic esophagitis began individual feeding therapy concerns rigidity difficulty transitioning limited peer interactions led neuropsychological evaluation kendra diagnosed asd avoidant restrictive food intake disorder arfid cognitive skills average expressive receptive language skills low average diet consisted french fries ritz crackers pretzels ounces soy formula daily stopped accepting cheerios saltines months prior controlled aspects feeding insisting specific parking spot fast food restaurant drinking particular sippy cup parents accepted demands concern caloric intake tracked daily following diagnosis arfid resumed feeding therapy using systematic desensitization approach rewards first session kissed licked new foods without gagging mother appeared receptive recommendations included continuing food game home replacing ounce soy formula offering water day limiting meal grazing refusing specific feeding demands currently parents plan discontinue feeding therapy concerns treatment harsh father produces logs caloric micronutrient intake evidence replace missed formula foods reports subsequently became difficult manage behaviorally father demands see randomized controlled trials feeding therapy approaches weight stable limited pretzel intake specific brand would approach continued care
contribute clarifying mechanisms operating nose chemosensory epithelia developmental patterns analyzed expression different epithelial membrane transporters well clara cell secretory protein olfactory vomeronasal organ vno respiratory epithelia embryonic postnatal mice means immunohistochemistry reverse transcriptase polymerase chain reaction results showed camp activated chloride channel cftr water channel protein aquaporin aqp aqp aqp aqp expressed developing adult chemosensory epithelia differential timing moreover pattern expression identical vno olfactory epithelia well corresponding associated glands localization experiments using olfactory marker protein showed cftr aqp expressed olfactory neurones cftr expressed sustentacular cells vno olfactory epithelium well blood vessels underlying mucosa vno bowman glands similar pattern excluding blood vessels present aqp aqp found two chemosensory epithelia bowman glands aqp expressed olfactory epithelium associated bowman glands vno chemosensory epithelium glands aqp expressed olfactory epithelium bowman vno glands results indicate water ions handling well antioxidant mechanisms operating surface inside nose chemosensory epithelia start developing utero maintained sexual maturity wiley periodicals inc develop neurobiol
educational attainment shown positively associated mental health potential buffer stressful events one stressful life event likely affect everyone lifetime bereavement paper assesses effect educational attainment mental health post bereavement utilising large administrative datasets linking census returns death records prescribed medication data analysed bereavement exposure individuals aged years two level multi level logistic regression models constructed determine likelihood antidepressant medication use proxy mental ill health post bereavement given level educational attainment individuals bereaved greater antidepressant use bereaved quarter bereaved suicide receipt antidepressant medication compared bereaved within individuals bereaved sudden death university degree higher qualifications less likely receipt antidepressant medication compared qualifications full adjustment demographic socio economic area factors higher educational attainment qualifications equivalent effect bereaved suicide education may protect poor mental health measured use antidepressant medication post bereavement except bereaved suicide likely due improved cognitive personal psychological skills gained time spent education
longitudinal study examined relations physical quality housing neighborhood interactive effect life course development rural children ages years standardized instruments assessed housing quality structural clutter cleanliness indoor climate hazards crowding privacy neighborhood quality street connectivity density land use mix proximate building sidewalk conditions neighborhood stability proximity nature amenities analyses focused two critical components child development psychological health helplessness growth curve analyses multilevel modeling revealed lower quality housing associated poorer psychological health internalizing externalizing symptoms well marginally helplessness behavioral task years ages years analyses statistically controlled income level neither neighborhood quality interaction housing quality related psychological health motivation elsevier ltd rights reserved
noise addition data distortion technique widely used data intensive applications example machine learning tasks helps reduce overfitting whereas data privacy protection adds uncertainty personally identifiable information yet due mathematical operating principle noise addition method mainly intended continuous numerical data fact despite large amount nominal data currently compiled used data analysis alternative techniques proposed distort nominal data similar way standard noise addition numerical data furthermore alternative methods rely distribution data rather semantics nominal values negatively affects utility distorted outcomes tackle issue paper present semantically grounded alternative numerical noise suitable nominal data name semantic noise means semantic noise exploiting structured knowledge sources ontologies able distort nominal data preserving better semantics thus analytical utility end provide semantically mathematically coherent versions statistical operators required noise addition process include difference mean variance covariance propose semantic noise addition algorithms cope finite discrete non ordinal nature nominal data proposed algorithms cover uncorrelated noise addition suited independent attributes correlated noise addition cope multivariate datasets dependent attributes empirical results show proposals offer general configurable mechanisms distort nominal data preserving data semantics better baseline methods based distribution data elsevier rights reserved
objectives assess provision need dermatologic care among dutch nursing home patients obtain recommendations improvement design cross sectional nationwide survey setting nursing home organizations netherlands participants physicians working nursing homes measurements web based questionnaire concerning burden skin diseases nursing home patients diagnostic procedures therapy collaboration dermatologists physicians level education suggestions improvement results total nursing home organizations associated physicians participated study received questionnaire total physicians completed questionnaire almost respondents recently confronted skin diseases mostly pressure ulcers eczema fungal infections diagnostic treatment options limited lack availability experience physicians live consultation dermatologists suggested important improve dermatologic care suggestions better education usage telemedicine applications better availability diagnostic treatment procedures like cryotherapy conclusion physicians nursing homes frequently confronted skin diseases several changes organization care education expected improve dermatologic care nursing home patients amda society post acute long term care medicine
gca pmr conditions older persons frequently overlap traditional concept gca focused cranial symptoms headache visual disturbance extra cranial manifestations constitutional symptoms polymyalgia limb claudication also long recognized symptoms may coincide cranial gca occur independent clinical subset large vessel gca overlap pmr imaging studies demonstrated one third patients pmr subclinical inflammation disease outset implication finding pmr management unclear pathophysiological studies emphasized pivotal role dendritic cells dcs cells pathogenesis gca activation certain pattern recognition receptors dcs may determine clinical subset gca patients pmr clinically conceivable transmural arterial inflammation either yet started prevented unexplored regulatory pathways concept supported vasculitis peri adventitial small vessels activated dcs adventitia temporal arteries absence media infiltrating cells review examines clinical pathophysiological spectrum gca subsets pmr role newer imaging techniques gca diagnosis management diseases
thermochromic vanadium dioxide film potential material smart window high refractive index coating visible band resulted strong reflection low visible transmission another coating definite low refractive index laid film construct gradient index multilayer system total reflection could effectively reduced therefore paper designed mesoporous sio double layer system mesoporous sio layer possessed index adjustable reduce surface reflection based smart window mesoporous structure investigated several techniques including gisaxs tem desorption important facile safe low cost solution method employed prepare film thickness directly ammonium citrato oxovanadate compound reported previously newly designed mesoporous sio double layer coating integral visible transmittance degrees vis increased pure coating corresponsive integral visible transmittance degrees vis increased pure coating index mesoporous sio layer optimized simultaneously near infrared switching ability delta reached solar energy modulation delta sol maintained phase transition temperatures coating optimized sio double layer coating degrees degrees respectively far degrees bulky optical performance attractive application smart window little increased cost greatly enhanced property
objectivewe examined relationship american indian men attitudes toward pregnancy prevention sti hiv prevention sexual risk behavior attention given attitudes intentions use condoms sexual risk behavior sti hiv prevention characteristics sexual risk behavior attitudes toward abstinence monogamy sexual risk behavior decision making relationships sexual risk behavior study designour sample included heterosexual american indian men aged living reservation data collected depth interviews community based participatory research framework used ensure relevancy acceptability study given sensitivity topic principal findingsresults demonstrated attitudinal factors associated sexual risk behavior particularly inconsistent condom use attitudes associated consistent condom use suggested greater levels positive dispositions toward prevention intention use condoms consistent condom use associated cautious attitudes toward sex multiple sex partners study results suggested american indian men reported sex multiple partners exhibited set attitudes beliefs toward pregnancy prevention sti hiv prevention corresponded disposition resulting behaviors engaging sexual risk behavior elevated levels risk perception conclusionsour findings suggest heterosexual american indian men living rural environments need sexual reproductive health programs clinical services address differing attitudes toward condom use within context multiple sex partners sexual risk behavior
irreversible electroporation ire considered predominantly non thermal ablative technique uses electrical fields permeabilize cell membranes lead cell death study evaluated efficacy ire rabbit breast cancer model thirty five female new zealand white rabbits inoculated breast cancer cells rabbits randomly divided two groups control group rabbits ire treatment group rabbits treatment treatment outcome evaluated computerized tomography scan plain contrast enhanced tumor growth curves pathological examination including tunel pcna staining rabbits ire treatment group experienced successful ire without obvious complications except thoracic major muscle injury focused complete well defined ablation zone tumor cells thoroughly eradicated detected staining along increasing tunel staining expression pcna regulated periphery ablation region last follow rabbits ire group demonstrated disease control rabbits stable condition rabbits suffered disease progression remaining rabbits sacrificed pathological examination halfway study overall efficacy ire demonstrated creation complete ablation region increased apoptosis ablation zone decreased proliferation microvessel density tumor tissue periphery ire promising local treatment breast cancer
paper describes fully coupled finite element finite volume approach simulating field scale hydraulically driven fractures three dimensions using massively parallel computing platforms proposed method capable capturing realistic representations local heterogeneities layering natural fracture networks reservoir detailed description numerical implementation provided along numerical studies comparing model analytical solutions experimental results results demonstrate effectiveness proposed method modeling large scale problems involving hydraulically driven fractures three dimensions authors international journal numerical analytical methods geomechanics published john wiley sons ltd
background objective segmentation femur hip joint computed tomography important preliminary step hip surgery planning simulation however time consuming challenging task due weak boundary varying topology hip joint extremely narrow blurred space femoral head acetabulum address problems study proposed semi automatic segmentation framework based harmonic fields accurate segmentation methods proposed method comprises three steps first high level information provided user shape information provided neighboring slices well statistical information mask region selection method proposed effectively locate joint space harmonic field second incorporated improved gradient harmonic field used adaptively extract curve barrier separates femoral head acetabulum accurately third divide conquer segmentation strategy based harmonic barrier used combine femoral head part body part final segmentation result results tested hips considerately narrow disappeared joint spaces experimental results evaluated based jaccard dice directional cut discrepancy dcd receiver operating characteristic roc achieve higher jaccard dice area curve auc lower error dcd effective ratio method even cases severe malformation results show method performs best terms effectiveness accuracy whole data set conclusions proposed method efficient segment femurs narrow joint space accurate segmentation results assist physicians osteoarthritis diagnosis future elsevier rights reserved
objective rare disease background primary pituitary tuberculosis absence organ involvement constitutional symptoms extremely rare disease total reported cases literature fewer hundred misdiagnosis pituitary adenoma common late diagnosis result permanent endocrine dysfunction long term neurologic sequelae case report report case middle aged woman presented severe headache left third cranial nerve palsy magnetic resonance imaging mri revealed large pituitary tumor invading left cavernous sinus case initially misdiagnosed pituitary adenoma pituitary biopsy performed suggestive pituitary tuberculosis extensive radiologic investigations reveal evidence organ involvement tuberculosis successfully treated anti tuberculous medications conclusions areas high pre test probability tuberculosis pituitary tuberculosis included differential diagnosis pituitary tumors order avoid unnecessary surgical interventions besides first histologically proven primary pituitary tuberculosis case reported qatar current case unique extensive radiologic investigations reveal evidence systemic pulmonary tuberculosis
location aware service las imperative topic ambient intelligence las recommends suitable utilities user based user location context however current lass several problems services last study proposes optimization based approach enhancing sustainability las paper problems related optimizing las system presented distinct nature las optimization problem comparison traditional optimization problems subsequently described existing methods applicable solving las optimization problem also reviewed advantages disadvantages method discussed motive combining multiple optimization methods study illustrated example finally opportunities challenges faced researchers field presented
distributed real time systems present particular challenge two key problems solved development first deployed protocols must provide deterministic behavior enable predictable outcome second implementations protocols compliance stringent timing constraints stated protocols ensure runtime behavior remains deterministic particularly requires adequate isolation time critical protocols less preferential applications installed node paper present protocol framework bips tackles challenges wireless sensor networks imote hardware platforms besides summarizing various mac protocols best effort real time capable protocols operating system functionalities provided bips paper presents comparative evaluations tinyos state practice operating system wireless sensor networks real time operating system riot results show protocols realized bips outperforms solutions predictability execution times thereby providing evidence advantages bips real time systems
introduction trochanter minor fractures generally seen ages years due sports injuries physis line open less frequently seen adults adolescents study old patient presented admitted emergency department twice one day hip pain trochanter minor fracture detected case report year old male brought emergency department complaints right hip pain difficulty walking patient first radiologic examination could determine pathology fracture allowed home analgesic bed rest proposal outpatient control discharge patient readmitted emergency clinic second radiologic examination displaced fracture trochanter minor right femur detected preparing patient surgery trochanter minor stabilized cable plate system conclusion physicians must careful first examination hip pain elderly secondary femoral neck fractures occur older patients without underlying etiology suggest prophylactic surgery must choice treatment strategy
background traditionally assessment psychiatric symptoms relying retrospective report trained interviewer emergence smartphones facilitates passive sensor based monitoring active real time monitoring time stamped prompts however validated self report measures designed purpose methods introduce novel compact questionnaire mood zoom embedded customised smart phone application asks participants rate anxiety elation sadness anger irritability energy point likert scale comparison used four standard clinical questionnaires administered participants weekly quantify mania asrm depression qids anxiety gad quality life monitored bipolar disorder borderline personality disorders bpd healthy control participants study longitudinal median iqr days variation differences mood traits exploring data using diverse time series tools results correlated well vertical bar vertical bar differences variability questionnaires three cohorts compared bpd participants exhibit different trends variability average higher self reported scores mania depression anxiety lower quality life particular analysis variability differentiate bpd hitherto possible using weekly questionnaires limitations reported scores rely self assessment lack ongoing clinical assessment experts validate findings conclusions could used efficient long term effective daily monitoring mood instability clinical psychiatric practice authors published elsevier
areas computer science software domain particular international conferences important journals venue disseminate research results resulted creation rankings provide quality assessment conferences specially used academic promotion purposes like well known core ranking created computing research education association australasia paper analyze core ranked conferences software area covering aspects software engineering programming languages software architectures like included dblp dataset online reference computers science bibliographic information define suite metrics focusing analysis authorship graph conferences authors represented nodes authorship relationships edges aim first characterize patterns structure community researchers software conferences try see values depend quality rank conference justifying way existence different classifications core ranking system
introduction chronic insomnia public health crisis affecting population costing billions dollars annually typically presents one comorbid psychiatric organic conditions historical classification chronic insomnia secondary presenting comorbid condition resulted recognition treatment insomnia comorbid condition though critical model comorbid disease management chronic insomnia receives little public policy attention method conducted systematic review recent empirical studies review papers books government documents press releases advertisements articles pertaining classification epidemiology treatment physiology sleep insomnia comorbid conditions data located primarily medline psycinfo scopus pubmed databases objective results goal provide overview systems classifying insomnia available epidemiological data review theoretical models regarding etiology maintaining factors chronic insomnia along research complex bidirectional associations chronic insomnia various affective conditions conclusions thorough review literature propose several public policy measures initial step managing chronic insomnia united states include introducing nation wide multi modal educational awareness campaign titled sleep america increasing availability demand behavioral sleep medicine initially preferred treatment approach increasing use monitoring enforcement activities regulatory authorities curtail false misleading claims sponsors supplements treatments insomnia adoption measures hope galvanize national interest healthy sleep evidence based treatment chronic insomnia elsevier rights reserved
recent work revealed relationship pathological video game use increased impulsivity among children adolescents studies also demonstrated increased risk taking outside video game environment following game play work largely focused one genre video games racing motivated findings aim current study examine relationship pathological non pathological video game use impulsivity risky decision making current study also investigated relationship experience two popular genres video games first person shooter fps strategy risky decision making consistent previous work similar current sample college aged adults met criteria pathological video game use number hours spent gaming per week associated increased impulsivity self report measure temporal discounting task relationship sensitive genre video game specifically experience fps games positively correlated impulsivity experience strategy games negatively correlated impulsivity hours per week pathological symptoms predicted greater risk taking risk task iowa gambling task accompanied worse overall performance indicating even risky choices pay individuals spent time gaming endorsed symptoms pathological gaming continued make choices based data suggest presence pathological symptoms genre video game fps strategy may important factors determining amount game experience relates impulsivity risky decision making
paper presents system integration hierarchical control implementation inverter based microgrid research laboratory mgrl aalborg university denmark mgrl aims provide flexible experimental platform comprehensive studies microgrids structure laboratory including facilities configurations communication network first introduced complete control system based generic hierarchical control scheme including primary secondary tertiary control primary control loops developed implemented digital control platform system supervision advanced secondary tertiary management realized microgrid central controller software hardware schemes described several example case studies introduced performed achieve power quality regulation energy management flywheel energy storage system control experimental results presented show performance whole system
hyperspectral anomaly detection important problem remote sensing field make full use spectral differences discover certain potential interesting regions without target priors traditional mahalanobis distance based anomaly detectors assume background spectrum distribution conforms gaussian distribution however similar distributions may satisfied real hyperspectral images moreover background statistics susceptible contamination anomaly targets lead high false positive rate address intrinsic problems paper proposes novel method based graph theory first construct vertex edge weighted graph utilize pixel selection process locate anomaly targets two contributions claimed paper background distributions required makes method adaptive vertex edge weights considered enables accurate detection performance better robustness noise intensive experiments simulated real hyperspectral images demonstrate proposed method outperforms benchmark competitors addition robustness proposed method validated using various window sizes experimental result also demonstrates valuable characteristic less computational complexity less parameter tuning real applications
studied women poor knowledge different aspects osteoporosis complications suggesting educational programs targeting women particular needed help improve osteoporosis practice societies reduce burden disease purpose family structure changed considerably past decade women iran many countries region even families similar cultural background living parts world still responsible childcare well lifestyle adapted family present study conducted assess awareness female head household osteoporosis complications methods part population based study two iranian cities arak sannandaj study osteoporosis risk factors questionnaire knowledge female head households osteoporosis complications completed subsample filled knowledge survey along questionnaire demographic data socioeconomic status ses reproductive factors bone related lifestyle habits family personal medical history medication use compliance osteoporosis medication used well ffq filled participants also underwent bone mineral density bmd test serum levels vitamin calculated data used assess factors affecting awareness level results knowledge studied women found poor different aspects osteoporosis complications multivariate analysis revealed level increase vit intake tertile increases chance higher awareness level total times level increase physical activity tertile associated lower chance good knowledge conclusion considering poor awareness level studied women poor practice bone healthy behavior one could conclude programs needed content delivery style existing ones optimized
paper efficient image watermarking scheme based lagrangian support vector regression lsvr lifting wavelet transform lwt proposed balance trade imperceptibility robustness lwt faster efficient implementation traditional wavelet transform lsvr faster learning speed high generalization capability compared classical support vector regression combination lwt lsvr based image watermarking show imperceptibility robustness also reduces time complexity first image decomposed four subbands using one level lwt low frequency subband approximate image partitioned non overlapping blocks selected blocks based correlation wavelet coefficients used embed binary watermark logo selected block significant wavelet coefficient used target lsvr neighboring coefficients feature vector act input lsvr security watermark achieved applying arnold transformation original watermark scrambled watermark bit embedded comparing output predicted value lsvr selected block actual target value good learning capability high generalization property lsvr noisy datasets provides successful extraction watermark several image processing attacks median filtering average filtering addition gaussian noise salt pepper noise contrast enhancement blurring scaling cropping rotation experimental results show proposed scheme gives significant improvement imperceptibility robustness compared state art techniques
describe studies designed evaluate scores multidimensional shame related response inventory msri recently developed instrument measures affective behavioral responses shame inventory assesses shame related responses categories negative self evaluation fear social consequences maladaptive behavior tendency study undergraduates completed msri confirmatory factor analysis supported validity msri factor structure latent variable modeling coefficient alpha provided strong evidence internal consistency scores scale study undergraduates completed instrument along concurrent measures chosen clinical significance achievement factorial invariance supported use msri scale scores make valid mean comparisons across gender addition msri scale scores associated expected scores measures self harm suicide risk factors taken together results studies support internal consistency reliability factorial validity factorial invariance convergent validity scores msri work needed assess temporal stability msri scale scores invariance across clinical status groupings item level measurement properties viability highly symptomatic samples
background community pharmacists require access consumers information medicines health related conditions make informed decisions regarding treatment options open communication consumers pharmacists ideal although consumers likely disclose relevant information feel privacy requirements acknowledged adhered objective study sets explore community pharmacy privacy practices experiences expectations utilization available space achieve privacy methods qualitative methods used comprising series face face interviews pharmacists pharmacy customers perth western australia june august results use private consultation areas certain services sensitive discussions supported pharmacists consumers although recognition workflow processes pharmacies may need change maximize use private areas pharmacy staff adopted various strategies overcome privacy obstacles taking consumers quieter part pharmacy avoiding exposure sensitive items packaging lowering voices interacting pharmacy quiet times telephoning consumers pharmacy staff consumers regularly apply judgement achieve required level privacy discussion management privacy challenging community pharmacy environment going work area important community pharmacy practice increasingly becoming involved advanced medication disease state management services unique privacy requirements pharmacies layouts systems address privacy challenges require proactive approach
objective examine time trends disparities low income children health insurance coverage access care family immigration status methods used data national survey children health including children aged years family incomes federal poverty level examined immigration status categories citizen children nonimmigrant parents citizen children immigrant parents immigrant children used multivariable regression analyses obtain adjusted trends health insurance coverage access care results low income children experienced gains health insurance coverage access care regardless family immigration status relative citizen children nonimmigrant parents citizen children immigrant parents percentage point greater increase health insurance coverage percentage point greater increase personal doctor nurse percentage point greater increase unmet medical need immigrant children significantly lower health insurance coverage groups however group percentage point greater increase personal doctor nurse percentage point greater increase unmet medical need relative citizen children nonimmigrant parents conclusions disparities access care related family immigration status lessened time among children low income families although large disparities still exist policy efforts needed ensure children immigrant parents immigrant children able access health insurance health care
perfectionism proposed transdiagnostic risk factor linked eating disorders anxiety current study examine domains contingent self worth potential moderators relationships maladaptive perfectionism disordered eating anxiety using two waves data collection undergraduate females completed online surveys study core constructs two points separated months bivariate level maladaptive perfectionism positively associated disordered eating anxiety maladaptive perfectionism appearance relationship contingent self worth interacted predict increases disordered eating neither interactive models predicted change anxiety findings highlight maladaptive perfectionism transdiagnostic construct related disordered eating anxiety interactive findings suggest targeting maladaptive perfectionism contingent self worth appearance relationship prevention treatment efforts could mitigate risk development increase disordered eating
paper proposes modified cascaded multilevel grid connected inverter mcm gci suitable photovoltaic grid connected generation system considers wide operation range low grid current total harmonics distortion thd high european efficiency proposed topology bidirectional power switch added standard single phase cascaded multilevel inverter cmi implement transformation cmi mode bridge inverter hbi mode online topology transformation approach mcm gci proposed guarantee topology modes transformed safely smoothly proposed mcm gci operates cmi mode arrays output voltage power low transforms hbi mode arrays output voltage power high experimental results five level mcm gci represented validate feasibility proposed topology also compared three classic grid connected inverters highlight advantages furthermore structures based hybrid cmi possess topology transformation ability shown improve generation range obtain higher efficiency system
background purpose gene set enrichment analysis gsea find general trends huge lists genes proteins generated many functional genomics techniques bioinformatics analyses results present setrank advanced gsea algorithm able eliminate many false positive hits key principle algorithm discards gene sets initially flagged significant significance due overlap another gene set algorithm explained detail performance compared methods using objective benchmarking criteria furthermore explore sample source bias affect results gsea analysis conclusions benchmarking results show setrank highly specific tool gsea furthermore show reliability results improved taking sample source bias account setrank available package online web interface
paper presents high voltage inverter generate bipolar voltages variable duty cycle frequency pulsed power electrical network applications one four inverter switches built series stack semiconductor devices derived marx generator concept using small capacitors equally share voltage among individual series stacked semiconductors sliding mode control used control output voltage delay technique used reduce inverter output balance capacitor voltages design structure inverter switches described together delay technique steady state dynamic behavior evaluated simulation results presented using matlab simulink software discussed
extant family policy united states relates children already born propose policy extended order enhance psychological welfare children prior conception use sperm banking industry case study theorize extended donor profiles constituting socializing text donor offspring building identity process theory concept genealogical bewilderment assume many sperm recipients especially single mothers lesbian couples may want show future children profile father informed connell hegemonic masculinity theory content analyzed extended sperm donor profiles six american sperm banks found traditional masculinity prevails hence contend discrepancy monolithic traditional way masculinity performed text diverse masculinities gender roles family types donor offspring reality experiencing discrepancies may cause stress offspring propose family policy expanded elaborated regulate contents extended profiles order ensure repertoire greater diversity family structures well variety masculinities
background world population lived countries overweight obesity kills people underweight evolutionary perspectives provide holistic understanding obesity develops long term implications aim test whether maternal capital hypothesis evolutionary perspective viable explaining development obesity adulthood subjects methods restricted use data national longitudinal study adolescent health add health analysed using logistic regressions sample included adolescents biological mothers results odds obesity adulthood increased every standard deviation increase lack maternal capital exp individuals whose mothers young ethnic minority short breastfeeding durations likely obese adulthood even controlling factors infancy adolescence adulthood results showed whose mothers lower capital prone later life disease specifically obesity conclusion maternal capital perspective useful explaining early life characteristics including maternal resources predict obesity adulthood implications findings discussed
current topics learning management systems encourage innovative technologies use digital libraries exploit learning objects metadata order facilitate dissemination process content digital repositories mostly implemented distributed computing systems architectures dealing major technological modeling issues hinder interoperability heterogeneous databases impeding data accessibility reusability learning object metadata lack interactivity address operational deficiencies though content structure systematic approach needs established promising method employ learning object metadata adaptation use semantic web technologies expressing semantics learning material heal interoperability issues improve information retrieval providing knowledge representation inherent xml syntax applying inference rules work develops ontology web model learning object metadata detecting semantic relations educational material aims assess abstract level tutoring content improve learning procedure
background peer relationships important children mental health yet little known etiological underpinnings explore genetic influences childhood peer network characteristics three different networks defined rejection acceptance prosocial behavior examine impact early externalizing internalizing trajectories peer network characteristics methods participants children dutch generation birth cohort age mapped children classroom peer networks peer rejection acceptance prosocial behavior using mutual peer nominations network genetic influences estimated children degree centrality closeness centrality link reciprocity dna using genome wide complex trait analysis preschool externalizing internalizing trajectories computed using parental ratings ages years results three network properties examined closeness centrality emerged significantly heritable across networks preschool externalizing problems predicted unfavorable positions within peer rejection networks fewer mutual friendships contrast children preschool internalizing problems actively rejected peers less well connected within social support network conclusions finding significant heritability closeness centrality taken preliminary evidence requires replication nevertheless orient role genes shaping child position within peer networks additionally social network perspectives offer rich insights early life mental health trajectories impact child later functioning within peer networks
atomistic quantum dot cellular automata qca based implementations reversible circuits got tremendous exposures last days due room temperature workability qca researchers serious need methodology realize area efficient qca counterparts reversible benchmark circuits work novel methodology named majoritylayered hybridization proposed synthesize reversible circuits using qca firstly reversible library consisting cnts gates generated validate usability proposed methodology elementary qca module toffoli gate proposed extended realization toffoli gates multi control toffoli gates proper mathematical modelling several qca design metrics like effective area delay cost established qca counterpart toffoli gate reports less effective area less cost compared previous toffoli gate designs moreover qca layout reversible benchmark using multi control toffoli gate employed verify scalability reproducibility proposed methodology qca layouts generated tested simulated renowned computer aided design tool qcadesigner
objetive describe structure processes multidisciplinary care models psoriatic arthritis psa spain well barriers facilitators implementation methods qualitative study performed following structured interviews professionals rheumatologists dermatologists provide multidisciplinary care patients psa collected data related hospital department population multidisciplinary care model type physical human resources professional requirements objectives referral criteria agendas protocols responsibilities decision making research education clinical sessions development planning model advantages disadvantages model barriers facilitators implementation model models characteristics described results analyzed multidisciplinary care models psa least years experience subtypes models face face parallel preferential circuit adapted hospital professionals characteristics proper implementation planning essential involvement empathy professionals access well defined referral criteria important facilitators implementation model management agendas data collection measure multidisciplinary care models health outcomes main barriers conclusions different multidisciplinary care models psa improve patient outcomes system efficiency collaboration specialists elsevier espana sociedad espanola reumatologla colegio mexicano reumatologla rights reserved
shrinking processor feature operating voltages processor circuits making increasingly vulnerable soft faults calls fault resilience techniques software hardware levels big data context assist software developers writing fault resilient big data applications propose tool errorsight helps focus efforts code regions data structures vulnerable soft errors understand numerical errors propagate program apply fault resilience techniques effectively errorsight achieves efficient generation error profiles leveraging predictive power boosted regression tree model use four big data kernels illustrate modular analysis mechanism errorsight show usefulness development numerical fault resilience big data
tumor necrosis factor tnf alpha potent pro inflammatory cytokine exerting pleiotropic effects various cell types synthesized precursor form called transmembrane tnf alpha mtnf alpha processed metalloproteinases released soluble form mediate biological activities type tnf receptors tnf receptor expressing cells addition acting soluble form tnf alpha also acts transmembrane form ligand activating tnf receptors well receptor transmits outside inside reverse signals back mtnf alpha bearing cells since discovery tnf plays determining role pathogenesis several chronic inflammatory diseases anti tnf agents increasingly used treatment rapidly expanding number rheumatic systemic autoimmune diseases rheumatoid arthritis crohn disease psoriasis psoriatic arthritis ankyloting spondylitis wegener granulomatosis sarcoidosis tnf antagonists currently available etanercept soluble tnf receptor construct infliximab chimeric monoclonal antibody adalimumab golimumab fully human antibodies certolizumab pegol fab fragment humanized anti tnf alpha antibody though compound efficiently neutralize tnf alpha increasing evidence suggests show different efficacy treatment diseases observations indicate addition neutralizing tnf alpha biological effects induced tnf alpha targeting molecules dictate success therapy recently found mtnf alpha reverse signaling leads transforming growth factor tgf beta production macrophages anti tnf agents selectively trigger pathway review focus potential contribution activation mtnf alpha signaling pathway success anti tnf therapy elsevier ltd rights reserved
consider contraction shift viscous shocks scalar viscous conservation laws strictly convex fluxes one space dimension case flux small perturbation quadratic burgers flux show viscous shock induces contraction shift norm difference solution viscous conservation law appropriate shift shock wave increase time addition difference initial value solution shock wave also bounded norm difference converges optimal rate results involve smallness condition initial value size shock context small perturbations quadratic burgers flux result improves choi vasseur result however show contraction shift hold every convex flux construct smooth strictly convex flux contraction hold even along lipschitz shift elsevier masson sas rights reserved
last years several papers become available literature main hallmarks alzheimer disease several intracellular pathways whose alteration responsible onset progression use transgenic nontransgenic animal models played key role achieving remarkable amount preclinical data allowing researchers dissect cellular changes occurring brain addition huge amount preclinical evidence arising animal models necessary clinical development pharmacological agents capable interfering impaired neural pathways patients respect significant role played dysfunction excitatory inhibitory neurotransmission responsible cognitive behavioral symptoms described patients aim review summarize main animal models contributed toward unraveling pathological changes neurotransmitter synthesis release receptor binding preclinical studies review also provides updated description current pharmacological agents still clinical development acting neurotransmitter systems wolters kluwer health inc rights reserved
although etiology pathology autism spectrum disorder asd still poorly understood number environmental anthropological neurobiological genetic factors related pathophysiology asd even impact oxidative stress response related environment nutrition intake usual recommended dietary habits based combination behavioral dietary nutraceutical interventions together pharmacotherapy investigations reliable relationship diet asd still lacking present study aimed comparing dietary regimens habits normally developing apparently healthy children without diagnosed asd pediatric population individuals affected autistic disorder assessments nutritional anthropometric data addition biochemical evaluation nutrient deficiencies performed total children autistic disorder healthy normally developing pediatric individuals enrolled study parents asked complete standardized questionnaire regarding different types food proportion serving children biochemical analysis micro macronutrients also done plotting egyptian sex specific anthropometric growth auximetric chart absolute weights well weight related age classes significantly higher cases healthy controls differences groups observed regard total kilocalories kcal carbohydrates fat intake total children autistic disorder healthy control group nutrient intake features recommended dietary allowance rda protein children autistic disorder showed low dietary intake micronutrients calcium magnesium iron selenium sodium also significantly high intake potassium vitamin compared healthy controls serum folate vitamin children autistic disorder significantly low compared healthy children significant positive correlations serum vitamin folate levels food present results confirmed different nutritional inadequacy observed egyptian children autistic disorder evidence reported present study recommend screening nutritional status asd children nutrient adequacy reduce deficiencies dietary means administering appropriate vitamin mineral supplements nutritional intervention plan tailored address specific needs
objectiveearly response eating disorders treatment thought predict later favourable outcome systematic review literature meta analyses examined robustness concept methodthe criteria used across studies define early response summarised following preferred reporting items systematic reviews meta analyses guidelines diagnostic test accuracy methodology used estimate size effect resultsfindings studies synthesized data studies included meta analysis anorexia nervosa odds ratio early response predicting remission summary area curve auc bulimia nervosa odds ratio auc binge eating disorder odds ratio auc conclusionearly behaviour change accurately predicts later symptom remission anorexia nervosa binge eating disorder less predictive accuracy bulimia nervosa copyright john wiley sons ltd eating disorders association
paper constructs model determining optimal capacities water projects including limited diversion dams flood control dams water transfer projects rainwater harvesting systems model helps analyze impacts institutional environmental technological changes capacity choices water projects analysis identifies conditions water reforms flood damages climate change could lead larger optimal water project capacities also systematically analyze relation water project capacities water conservation technologies drip irrigation identify conditions complements paper implies design water projects separated institutional environmental technological conditions upstream downstream elsevier rights reserved
rbio free software data processing compatible integrated free software globally accepted statistical analysis thus rbio takes advantage processing potential software however new software allows user perform analyses without knowing programming language rbio available portuguese downloaded internet http www biometria ufv requires windows operating system set sample files making easy used currently supplies user scripts internally used process analyses rbio perform descriptive statistics analysis variance estimation genetic parameters means tests multivariate analysis nonparametric tests regressions correlations biometrics bioinformatics simulation key words software programming data analysis quantitative genetics biometrics
understanding verbal descriptions everyday actions could involve neural representation action direction avoidance approach toward persons things recorded electrophysiological activity participants reading approach avoidance action sentences directed toward target thing person petra accepted rejected ramn group petra accepted rejected receipt bank measured brain potentials time locked target word case things found like component right frontal distribution modulated approach avoidance action component negative avoidance approach sentences case persons later negative event related potential left frontal distribution sensitive verb direction showing negative amplitude approach avoidance actions addition negativity approach person sentences associated fear avoidance trait whereas less negativity avoidance person sentences associated greater approach trait results support verbal descriptions approach avoidance actions encoded differently depending whether target thing person implications results social emotional motivational understanding action language discussed
experimental investigations carried order identify portable device requirements vitro muscle tissue monitoring time based investigations specifications measurement system defined considering type amplitude excitation signals frequency range khz mhz impedance range omega omega requirements portable device structure proposed based magnitude ratio phase difference detection using gain phase detector fulfill requirements gain phase detector circuit inputs interface circuit proposed error lower
objective analyze patterns causes tennis related injuries using first time nationally representative data set design retrospective cohort analysis performed using national electronic injury surveillance system database setting tennis related injuries treated emergency departments eds analyzed patients study period estimated confidence interval individuals aged years presented eds tennis related injuries assessment risk factors independent variables included patient age gender mechanism injury location injury event main outcome measures outcome variables included injury diagnosis body region injured disposition involvement net results injuries sustained nonspecific mechanism play occurred sport recreation facility children aged years higher mean injury rate adults older years commonly injured body regions lower extremities upper extremities sprains strains common type injury number tennis related injuries decreased years tennis related injury rates decreased study period among patients admitted hospital two thirds involved patients years age older conclusions despite decrease tennis related injuries growing popularity sport warrants increased efforts prevent injuries especially among child older adult participants
optimization systems increase efficiency appropriate system performance indices nowadays climate control industrial greenhouses consists many control parameters light temperature concentration humidity etc systems use pid control structure due simplicity flexibility good performance electrical lamps heaters used provide appropriate light temperature inside greenhouse optimal tuning electrical lamps heaters control system significant influence efficiency performance improvement greenhouse cultivation system aim nsga well knownevolutionary algorithm applied system optimization verified exhaustive search approach making final decision choose best solution among optimal solutions challenging decision making issue regard post pareto optimal pruning algorithms employed considering various user preferences clustering approaches final results show verify substantial improvement greenhouse climate control system efficiency performance
stressmanagementskill trainingwas always knowntoi benif icial depression anxiety stress applied patients suffering fromtype diabetes quasi experimental method following pre post test design method control group twenty diabetic patients females males selected randomly divide intotwogroups testandcontrol levels depression anxiety stress measured using depression anxiety stress questionnaire dass pre test phases followed stress reduction skill training conducted different sessions test group end interventions levels depression anxiety stress patientswere measured data analyzed using analysis variance signif icant differences levels depression anxiety stress two groups found finally reduced test group stress management skill training conclusively stress management skill could appropriate treatment method improving mood disorders inpatients suffering fromtype diabetes
background angiotensin converting enzyme ace inhibitor induced angioedema rare albeit serious emergency result airway compromise potentially death treated promptly currently agents approved food drug administration target ace inhibitor angioedema prevent intubation inhibitors approved hereditary angioedema may show promise alleviating inflammation associated ace inhibitor angioedema case report year old man presented emergency department swelling lips days starting lisinopril hypertension despite receiving diphenhydramine ranitidine methylprednisolone swelling progressed patient tongue inhibitor ordered effort prevent intubation arrival medication patient intubated emergently airway protection receipt inhibitor swelling dramatically improved patient successfully extubated less hours presentation emergency physician aware case illustrates potential role inhibitors emergency setting treating drug induced angioedema may prevent minimize mechanical ventilation time elsevier inc
review updates relationship adherence mediterranean diet meddiet assessed questionnaire asthma allergic rhinitis atopic eczema childhood deals effect meddiet children asthma wheeze allergic rhinitis atopic dermatitis eczema also effect meddiet consumption mother pregnancy inception asthma wheeze allergic diseases offspring adherence meddiet children seems protective effect asthma wheezing symptoms adjustment confounders although effect doubtful lung function bronchial hyperresponsiveness contrast vast majority studies showed significant effect meddiet preventing atopic eczema rhinitis atopy finally studies adherence meddiet mother pregnancy showed protective effect asthma wheeze symptoms offspring first year life afterward studies shown protective effect wheezing current sneeze atopy none eczema randomized control trials effect adherence meddiet prevent maternal consumption pregnancy improve child consumption clinical control asthma wheezing allergic rhinitis atopic dermatitis needed
solution secondary circuits effect consideration problem electrical network calculation presented paper analysis statistical operational data concerning primary secondary equipment failures taken directly plant performed follows analysis results relay protection automation consideration reliability calculation appropriate model permits solve reliability assessment problems elementary electrical substations circuits use probabilistic methods classical reliability theory developed base statistical data basic problems reliability calculation method application conditions real branched networks considered method importance development also evaluated
commercial aircraft use environmental control systems ecss control thermal environment cabins thus ensure passengers safety health comfort study investigated interaction ecs operation cabin thermal environment simplified models developed thermodynamic processes key ecs components commercial software program ansys simplorer computational fluid dynamics cfd program ansys fluent employed simulate thermal environment cabin coupling simplorer fluent pid control method applied aircraft ecs simplorer achieve dynamic control temperature supply air cabin used fluent input calculated supply air temperature agreed corresponding experimental data obtained aircraft ground coupled model used simulate complete flight purpose studying interaction ecs operation cabin thermal environment results show pid controller ecs maintain cabin air temperature within set point acceptable air temperature distribution coupled models used design analysis ecs cabin thermal environment commercial airplanes
magnitude concurrent malaria infection impact hematological abnormalities anemia people living hiv aids well studied ethiopian set cross sectional study therefore assessed prevalence concurrent malaria infection anemia among highly active anti retroviral therapy haart naive people living hiv aids october may northern ethiopia obtaining consent socio demographic clinical immunological behavioural data obtained overall prevalence concomitant malaria infection rural residents low middle income class clients frequently infected malaria utilization insecticide treated nets trimoxazole intake protective factors plasmodium infection overall prevalence anemia also high significantly higher malaria positive people living hiv aids compared malaria free hiv patients female gender history opportunistic infections late hiv stages iii also significantly associated anemia hiv patients conclusion concurrent malaria represents common condition significant difference odds anemia malaria positive negative people living hiv aids northern ethiopia indicating need routine screening people living hiv aids living malaria endemic areas close monitoring infected patients indeed utilization itns malaria prophylaxis early hiv diagnosis highly encouraged people living hiv aids elsevier rights reserved
paper presents nonlinear dynamic analysis structural system shape memory alloy members new time integration scheme proposed solving differential equation motion obtained system new implicit method assumed acceleration varies quadratically within time step terms taylor series used increasing order acceleration expected responses better accuracy classical methods adopting assumption new family unconditionally stable procedures obtained two dynamic loading cases considered numerical example structure analyzed elastoplastic behavior well structure enhanced superelastic shape memory alloy connections findings display nonlinear dynamic analysis conducted structures showed efficient accurate also found shape memory alloy permits system recover initial configuration end deformation process recovery takes place without residual strains dissipating considerable amount energy elsevier ltd rights reserved
antisocial personality disorder apd psychopathy extensively researched relationship criminal behavior aggression comparatively studies evaluated clinical constructs subtypes aggression specifically reactive instrumental aggression moreover published studies tend focus extremes either prisoners maximum security facilities college samples current study utilized jail detainees minimum security unit retrospectively examine self reported reactive instrumental aggression conduct disorder required apd combined apd symptomatology used predict subtypes aggression comparative analysis facet scores psychopathy checklist revised also used predictors results current study implications forensic practice utilizing aggression multi dimensional construct conjunction personality traits facets psychopathy risk assessments
summary internet search rates vitamin explored using google trends search rates increased thereafter displayed seasonal pattern peaking late winter knowledge could help guide timing public health interventions aimed managing vitamin deficiency purpose internet important source health information analysis internet search activity rates provide information disease epidemiology health related behaviors public interest explored internet search rates vitamin determine whether reflects increasing scientific interest topic methods google trends publically available tool provides data internet searches using google search activity term vitamin january october obtained comparison made bone nutrition related terms results worldwide searches vitamin increased thereafter statistically significant seasonal pattern peak february nadir august observed seasonal pattern evident searches originating usa peak february australia peak august searches terms osteoporosis rickets back pain folic acid display increase observed vitamin evidence seasonal variation conclusion public interest vitamin assessed internet search activity increase likely reflecting growing scientific interest displays seasonal pattern peak interest late winter information could used guide public health approaches managing vitamin deficiency
background despite research linking family meals healthier diets families unable regular meals together families need guidance ways promote healthy eating among adolescents objective aim examine association various parenting practices adolescent fruit vegetable intake different levels family meal frequency design conducted cross sectional population based survey influences adolescent weight related behaviors using project eat eating activity teens participants setting participants adolescents recruited middle high schools minneapolis paul measures adolescent intake ascertained food frequency questionnaire survey items assessed frequency family meals parenting practices availability accessibility parent modeling parent encouragement family communication statistical analyses linear regression models used examine associations interactions among family meals parenting practices models adjusted age sex socioeconomic status race ethnicity energy intake kilocalories per day results family meals availability accessibility modeling encouragement eat healthy foods independently associated higher intake adolescents reported infrequent family meals days mean intake servings day high home availability servings day low home availability similar differences mean intake servings day found high low accessibility parental modeling parent encouragement healthy eating frequent family meals addition favorable parenting practices associated highest intakes conclusions food parenting practices family meals associated greater adolescent intake longitudinal intervention studies needed determine combination parenting practices lead improvements adolescent diets
term nosql coined order unify numerous products enable data persistence access rather different ways compared relational databases movement mostly driven modern web sensor related applications cope high volume diverse data stored geographically separated systems case study show nosql product practical use impact alife solutions aimed improving citizens wellbeing stress management capabilities integrating knowledge different wellness disciplines designed handle billion new records every month demonstrate via case study introducing appropriate nosql solution particular system improves performance removes certain data handling obstacles contributes long term system stability
background general practitioners gps play key role care somatic psychiatric problems people diagnosed schizophrenia pws probable like health professionals gps free prejudices toward pws clinical practice gps sometimes interact clients diagnosed schizophrenia specialists passively accepting diagnosis times gps interact clients symptoms schizophrenia diagnosed case gps expected actively make diagnosis giving key role gps process care worthwhile examining whether passive acceptance active usage diagnosis schizophrenia differential effects gps attitudes toward people disorder aims investigate gps views schizophrenia whether influenced schizophrenia label passively accepted actively used methods total randomly selected gps invited complete questionnaire views schizophrenia either reading description disorder making diagnosis without provided description passively accepting label schizophrenia given questionnaire results gps passively accepted label schizophrenia actively identified schizophrenia description similar views compared gps identify schizophrenia description used diagnosis actively passively frequently reported heredity less frequently psychosocial factors causes disorder skeptical recovery convinced need long term pharmacotherapies believed strongly pws discriminated medical hospital perceived pws dangerous kept greater social distance conclusion diagnosis schizophrenia however used associated pessimistic views stigma education provided gps
paper examines use continuum damage model predict strength size effects notched carbon epoxy laminates effects size development fracture process zone final failure identified experimental program continuum damage model described resulting predictions size effects compared alternative approaches point stress inherent flaw models linear elastic fracture mechanics approach strength materials approach results indicate continuum damage model accurate technique predict size effects composites furthermore continuum damage model require calibration applicable general geometries boundary conditions elsevier ltd rights reserved
paper reviews career late nineteenth early twentieth century russian engineer aleksej nikolaevich krylov made prodigious contributions fields marine engineering naval architecture strength materials physics analogue computers ballistics applied mathematics astronomy engineering education surprisingly unknown west today krylov achieved international fame became first foreigner receive gold medal royal institution naval architects london years upheaval following russian revolution subsequent civil war krylov instrumental establishing scientific contacts west defining soviet technological policy later life erudition extended history science technology paper focuses first ground breaking work development methods correct compass deviation corresponding design new dromoscope
freedom one central values political moral philosophy number theorists hold freedom relatedly opportunity either least one central distribuenda theories distributive justice moreover many follow mill hold concern personal freedom guide limit paternalist public policy part theorists focussed person freedom one specific point time failed give proper attention freedom across time given care personal freedom reason care future freedom kind distribution freedom across person lifetime promote matter legislation public policy argue none candidate principles distribution freedom across time plausible neither starting gate view maximisation sufficientarian view satisfactory none adequately reflects various reasons value freedom show result presents tough challenge theories distributive justice paternalism set great store personal freedom
present study examines discussion individuals regarding shared memory affects subsequent individual memory reports three experiments pairs participants recalled items photographs common household scenes discussed recall recalled items individually results showed discussion individuals recalled correct items incorrect items small non significant increases change recall accuracy information people exposed discussion generally accurate although accurate individuals initial recall individuals incorporated correct exposure items subsequent recall higher rate incorrect exposure items participants initially accurate became less accurate initially less accurate participants became accurate result discussion comparisons discussion control groups suggest effects simply product repeated recall opportunities self cueing rather reflect transmission information individuals
laboratory professionals ideal situation identify cbc peripheral blood smear findings raise possibility hematolymphoid neoplasm based information make recommendations additional studies flow cytometric immunophenotyping circumstances definitive diagnosis established combined peripheral blood morphologic immunophenotypic findings obviating need bone marrow evaluation chronic lymphocytic leukemia occasionally flow cytometric studies superior morphologic assessment screening hairy cell leukemia identifying lymphocytic variant hypereosinophilia however increasing recognition small immunophenotypically unusual abnormal populations peripheral blood cells particularly older patients uncertain clinical significance monoclonal lymphocytosis cell clonopathy therefore important integrate peripheral blood smear review findings clinical information recommending flow cytometry addition important recognize situations results peripheral blood smear review flow cytometric immunophenotyping explain clinical findings
acceleration common car turbocharged diesel engine compared type electric motor terms kinematics starting state rest electric car reaches distant spot earlier diesel car even though latter better specification engine power average acceleration three phase model acceleration function time fits data electric car accurately first phase quadratic growth acceleration time shown tenfold higher coefficient first phase accounts kinematic advantage electric car
gatekeeping used theory measure describe assess family dynamics within context separation divorce article explore adaptive maladaptive gatekeeping behaviors attitudes affect parent relationship child implications presented connecting adaptive maladaptive gatekeeping responses child outcomes safety well positive parent child relationships following separation divorce build recent attention gatekeeping potential framework within child custody context key points family court community gatekeeping useful framework assessing parental behaviors attitudes facilitate protect restrict involvement parent child gatekeeping originally focused maternal behaviors facilitate restrict involvement fathers children attention shifted toward gender neutral framework assessing parents attitudes actions affect involvement quality relationship parent child rather set hardline rules govern behaviors gatekeeping requires working hypotheses consider various factors may contribute adaptive maladaptive gatekeeping responses
theorize two mind model design thinking mind logical design reasoning mind reflection reasoning judgments problem solving ability mind often emphasized software engineering reflective mind however received much attention study want find mind reflection improve design discourse prerequisite design quality conducted multiple case studies student groups divided test groups control groups provided external reflections test groups reflections given control groups analyzed quality design discourse groups found reflection mind improves quality design discourse mind certain preconditions results highlight significance reflection mean improve quality design discourse conclude software designers need mind mind obtain higher quality design discourse foundation good design copyright john wiley sons ltd
recent years seen increasing research within neuroscience biopsychology interactions brain gastrointestinal tract bacteria within gastrointestinal tract bidirectional relationship systems brain gut microbiome axis although research demonstrated gut microbiota impact upon cognition variety stress related behaviours including relevant anxiety depression still know occurs deeper understanding psychological development well social cultural factors impact upon brain gut microbiome axis contextualise role axis humans inform psychological interventions improve health within brain gut microbiome axis interventions ostensibly aimed ameliorating disorders one part brain gut microbiome axis psychotherapy depression may nonetheless impact upon parts axis microbiome composition function functional gastrointestinal disorders irritable bowel syndrome represent disorder axis rather isolated problem either psychology gastrointestinal function discipline psychology needs cognisant interactions help inform future research agenda emerging field research review outline role psychology play understanding braingut microbiome axis focus human psychology use research laboratory animals model human psychology
objective investigate effect using intrauterine devices iuds fertile window women reproductive system health materials methods postmenopausal women minhang district shanghai china enrolled iuds group women tubal ligation group women women control group selected subjects according cases number different hospital using step sampling addition collected sociological data information previously used contraceptives subjects included whether contraceptives used appropriately effect kolmogorov smirnov test levene test logistic regression analysis used analyze data results prevalence rate benign reproductive system conditions significantly different among comparison revealed rate group significantly lower group group respectively results logistic regression analysis show risk factors development conditions lie women pregnancy history odds ratio reproductive history use iud fertile window tubal ligation birth control time contraceptive failure history history family planning procedures conclusion iuds maybe effectively reduce risk getting benign reproductive conditions postmenopausal females
background exclusive enteral nutrition een therapy using polymeric formula substantially attenuate intestinal inflammation crohn disease patients however mechanism een suppresses inflammation yet fully understood aims examine cellular mechanism een may suppress inflammation investigate potential pathways enhance anti inflammatory properties een methods glutamine arginine vitamin linolenic acid ala present along curcumin identified immunoactive nutrient therapies tumor necrosis factor tnf exposed colonic epithelial cells used investigate immunosuppressive activity nutrients assessing effect cell viability cell activity chemokine response interleukin nuclear factor mitogen activated protein kinase kinase nitric oxide results cellular viability activity maintained nutrient treatments glutamine arginine vitamin ala significantly attenuated production glutamine arginine led phosphorylation blockade signaling components pathways reduction kinase activity enhancement production combining glutamine arginine curcumin optimal concentrations completely abolished response conclusions data indicate glutamine arginine vitamin suppress inflammation concentrations equivalent used mechanisms action mediated influencing cascades glutamine arginine fortified curcumin might promising option enhance effectiveness expand scope een therapy treatment
areal bone mineral density abmd predicts future fracture risk study explores development abmd associated factors norwegian adolescents results indicate high degree tracking abmd levels adolescence anthropometric measures lifestyle factors associated deviation tracking purpose norway one highest reported incidences hip fractures maximization peak bone mass may reduce future fracture risk main aims study describe changes bone mineral levels years norwegian adolescents aged years baseline examine degree tracking abmd period identify baseline predictors associated positive deviation tracking methods first year upper secondary school students tromso invited fit futures study adolescents attended measured femoral neck total hip total body abmd dxa two years later invited participants follow survey providing repeated measures abmd results abmd increased significantly skeletal sites sexes mean annual percentage increase tbwas girls boys respectively high degree tracking abmd levels years girls several lifestyle factors predicted positive deviation tracking whereas anthropometric measures appeared influential boys baseline score associated lower odds upwards drift sexes conclusions results support previous findings abmd development adolescence indicate strong tracking years follow baseline anthropometry lifestyle factors appeared alter tracking consistently across sex skeletal sites
transient analysis switching power converter spc circuits computationally expensive task high expense arises fact circuits driven clock period small compared time interval designer typically interested envelope following technique recently proposed literature efficient time domain simulation spc circuits paper parallel high order method based obreshkov formula presented analysis spc circuits numerical example presented demonstrate efficiency scalability proposed method parallel platforms
subject rotation workstations job rotation inside organizations seemed technically lots restrictions development adequate system rotation went need advanced ergonomic study even possible restrictions versatility training employees implementation ideal system rotation passes stages development research ergonomic study level employee versatility awareness discussion employees implementation proposed system feedback audits maintenance ideal sequence time rotation success project need multidisciplinary involvement areas manufacturing engineering industrial engineering human resources medical services manufacturing rotation tasks may mean worker conduct two different activities different parts day change activity activity hours hours interval important consideration ensure different activities present ergonomic risk body part tracing execution activity important factor production processes thus possible conduct appropriate levels training employees ensure safe sustainable processes terms workers health productivity quality
background sex hormones levels androgen receptor cagn polymorphism shown involved depressed mood aging men prior studies found inconsistent results role factors methods male participants aged years community based memory morbidity augsburg elderly memo study underwent physical examination medical interview including two scales center epidemiologic studies depression scale ces activities daily living scale adl testosterone shbg levels measured androgen receptor cagn polymorphism genotyped chi mann whitney test pearson correlations multivariable linear logistic regression used analysis results higher depressive scores significantly associated higher shbg levels beta coefficient shbg alone explained variance ces depression score mortality years follow predicted higher shbg levels higher adl scores older age current smoking depression score baseline model explained variance mortality number cag repeats neither related depression scores mortality conclusions found positive associations shbg levels old age male depression well mortality whether shbg testosterone independent effect context investigated elsevier ltd rights reserved
geosynthetic clay liners gcls often used lining materials freshwater reservoirs irrigate agricultural land without depleting groundwater surface water stored artificial ponds study hydraulic conductivity tests performed gcls placed flexible wall permeameters hydraulic heads order investigate risk internal erosion tests base pedestals made plexiglas uniform circular voids placed beneath gcls instead typical gravel subgrade voids base pedestal represented voids uniform rounded gravel particles different types gcls tested gcl reinforced using needle punching technology whereas gcl gcl gcl reinforced gcls assembled laboratory investigated effects internal erosion void size subbase geotextile component contact subbase bentonite component manufacturing process gcls test results indicated internal erosion directly related void diameter base pedestal resistance needle punched gcl internal erosion better reinforced gcls degree internal erosion also related engineering properties geotextile contact base pedestal higher tensile strength gcl reduced possible potential internal erosion within type bentonite significant effect internal erosion
water pollution industrial metro lodz poland made ner river almost fishless middle lower course century new sewage treatment plant reduction industry caused pollution abatement since result ner became repopulated shown fish samples collected along course multivariate statistical methods helped distinguish unpolluted upper course recovered iii middle lower course sections river historical present data indicated section iii downstream recovered least study section outflow one recovered fish fauna almost exclusively native displays high stable biomass abundance species richness including obligatory riverine species non native prussian carp dominance followed river degradation gradient highest section iii section declined almost absence study shows revival native fish fauna seems method restricting dominance highly tolerant species despite abatement storm events harmful fish mostly section iii ner discharge may increase manifold storm water drained combined sewer system ner several hours stressors numerous dams desorption pollutants sediment middle ner perhaps pollutant inflow agriculture local urban areas moderation storm impact water entering ner constructing buffer reservoirs would probably cause fish recovery section iii elsevier ltd rights reserved
background rathke cleft cyst rcc rare cystic sellar entity usually small size asymptomatic patients rcc presenting panhypopituitarism cystic lesion rim enhancement magnetic resonance imaging extremely rare therefore easy misdiagnosed pituitary abscess similar clinical manifestations neuroimaging changes casesummary report rare case rcc masquerading pituitary abscess clinically radiologically evidence central nervous system infection patient initially suspected diagnosed pituitary abscess denied histopathological findings rcc intraoperative drainage abscess present uncommon case rcc masquerading pituitary abscess year old chinese male patient patient admitted peking union medical college hospital complaining severe frontal pulsatile headache visual acuity deficit polyuria polydipsia slight disturbance consciousness biochemical endocrinological examinations revealed severe hyponatremia panhypopituitarism magnetic resonance imaging showed sellar lesion apparent cystic change rim enhancement accordingly pituitary abscess misdiagnosed beginning patient received hormone replacement therapy underwent trans sphenoidal surgery surgical findings uneventful histopathological examinations showed infiltration inflammatory cells pus proved lesion rcc conclusion rare case aim emphasize differential diagnosis sellar lesions requires constant vigilance rcc may lead clinical radiological changes similar pituitary abscess
paper describe development support system facilitates process learning computer programming reading computer program source code reading code consists two steps reading comprehension meaning deduction study developed tool supports comprehension program reading tool equipped error visualization function illustrates learner mistakes makes aware errors conducted experiments using learning support tool confirmed system effective
sleep impairment significantly alters human brain structure cognitive function available evidence suggests adults developed nations sleeping less growing body research sought use sleep forecast cognitive performance modeling relationship two generally focused vigilance rather cognitive constructs affected sleep reaction time executive function working memory previous modeling efforts also utilized subjective self reported sleep durations restricted laboratory environments current effort addressed limitations employing wearable systems mobile applications gather objective sleep information assess multi construct cognitive performance model predict changes mental acuity thirty participants recruited participation study lasted week using fitbit charge mobile version automated neuropsychological assessment metric called coggauge gathered series features utilized unified model performance predict mental acuity based sleep records results suggest individuals poorly rate sleep duration supporting need objective sleep metrics model circadian changes mental acuity participant compliance using wearable throughout week responding coggauge assessments specific biases identified temporal metrics across mobile devices operating systems excluded mental acuity metric development individualized prediction mental acuity consistently outperformed group modeling effort indicates feasibility creating individualized mobile assessment prediction mental acuity compatible majority current mobile devices
world gastroenterology organisation wgo omge federation national gastroenterology societies four regional gastroenterology associations representing individuals organization aims promote knowledge global prevalence digestive diseases among health professionals general public promote high quality accessible independent health education training programs especially emerging societies educational initiatives wgo include training centers train trainers workshops outreach program facilitates supply equipment materials world digestive health day global guidelines cascade methodology unique among guidelines world congress gastroenterology wgo foundation philanthropic body dedicated raising funds required support ongoing wgo education initiatives activities elsevier espana aeeh aeg rights reserved
plasma density feedback control system pdfcs established joint texas experimental tokamak text meeting need accurate plasma density physical experiments consists density measurement subsystem feedback control subsystem gas puffing subsystem according characteristic gas puffing system voltage amplitude control mode applied feedback control strategy accomplished proportion integral differential pid controller system quantity calibration gas injection adjusted responding change density signal carried experimental results shown discussed
business applications internet dependent web services transactions distributed denial service ddos attacks either degrade completely disrupt web services sending flood packets form legitimate looking requests towards victim web servers flash event overload condition caused large number legitimate requests similar characteristics ddos attacks therefore detection ddos attacks background traffic one hardest problems confronted network security researchers moreover ddos attacks fes require altogether different handling procedures paper traffic cluster entropy derived source address entropy combination used detect various types ddos attacks web services also distinguish ddos attacks fes optimal thresholds traffic cluster entropy calibrated receiver operating characteristic curve roc proposed detection approach operate one defence modes naive normal best based attack detection sensitivity requirements sensitivity detection metric tested using multiple simulation scenarios different types ddos attacks along variation origins attack traffic detection variety ddos attacks like high rate skewed ddos attacks low rate isotropic attacks subnet spoofed ddos attacks sophisticated ddos attacks demonstrated effectiveness proposed approach terms false positive rate detection rate classification rate validated simulations carried using linux platform elsevier ltd rights reserved
purpose purpose study describe underlying topics topic evolution year history educational leadership research literature method used automated text data mining probabilistic latent topic models examine full text entire publication history articles published educational administration quarterly eaq given computationally intensive data analysis required probabilistic topic models relying high performance computing used fold cross validation estimate model categorized article year one latent topics illustrated rise fall topics eaq year history findings model identified total topics eaq corpus among five topics inequity social justice female leadership school leadership preparation development trust teaching instructional leadership gained research attention year time period whereas research interest appears declined topic epistemology educational leadership since topics waxed waned past five decades implications study maps temporal terrain topics educational leadership field past years sheds new light development current status central topics educational leadership research literature important panoramic view topical landscape provides unique backdrop scholars contemplate future educational leadership research
magnesium oxide particles different morphologies synthesized using different precursors magnesium urea precipitating agent prepared samples magnesium oxide materials adsorption characterized means ray diffraction xrd ray photoelectron spectroscopy xps fourier transform infrared spectroscopy ftir scanning electron microscopy sem energy dispersive ray spectroscopy edx dsc thermal analysis adsorption properties adsorbents estimated compared treatment uranium containing wastewater magnesium oxide studied static state laboratory also effects adsorption time value wastewater temperature discussed investigation adsorption thermodynamics adsorption kinetics adsorption capacity three types mgo particles uranium optimum thermodynamic parameter calculation results indicate adsorption process spontaneous endothermic process elsevier rights reserved
background research spending persistence focused medicaid children health insurance program medicaid chip includes complex growing population objective study objective study describe patterns expenditure persistence mortality disenrollment among nondually eligible medicaid chip enrollees identify factors predicting outcomes research design study based new jersey medicaid chip claims data descriptive multinomial regression methods used characterize persistently extreme spenders defined appearing top statewide spending every year according demographics medicaid chip eligibility nursing facility residence patient risk scores clinical diagnostic categories measured similar analyses done persistently high spenders always top always top well decedents disenrollees moderate spenders least year outside top subjects nondually eligible medicaid chip enrollees results one fourth extreme spenders remained category throughout almost persistently extreme spenders aged blind disabled within aged blind disabled population strongest predictors persistently extreme spending diagnoses involving developmental disability hiv aids central nervous system conditions psychiatric disorders type diabetes renal conditions individuals nursing facilities high risk scores likely die persistently high spending persistently extreme spending conclusions study highlights unique features spending persistence within medicaid chip provides methodological contributions broader persistence literature
asthma chronic inflammatory disease lower airways characterised intermittent airway narrowing airflow obstruction aim study examine association arg gln cytokine gene polymorphisms know secretion cytokine levels interactions alpha alpha complex cytokine genes study population comprised atopic non atopic asthma patients healthy controls single nucleotide polymorphisms snps determined restriction fragment length polymorphism rflp cytokine serum levels measured enzyme linked immunosorbent assay elisa homology modelling cytokine gene performed silico analysis cytokine gene genotypes found significant atopic asthma patients mean serum cytokine levels found significantly high atopic non atopic asthma patients whereas total serum ige levels significantly high atopic low non atopic asthma patients compared silico analysis indicated residue charge modifying variants crucial ligand receptor interactions cytokine serum levels significantly high atopic nonatopic asthma patients compared genotype cytokine gene might involved induced production total ige cytokine serum levels suggesting may important signalling asthma
background objectives cognitive behavioral therapy cbt acceptance commitment therapy act garnered empirical support effective treatment social anxiety disorder however every patient benefits equally either treatment identifying moderators treatment outcome help better understand treatment best suited particular patient methods forty nine individuals met criteria social anxiety disorder assessed part randomized controlled trial comparing weeks cbt act pre treatment avoidance social situations measured via public speaking task clinician rating investigated moderator post treatment month follow month follow social anxiety symptoms stress reactivity quality life results public speaking avoidance found robust moderator outcome measures avoidant individuals generally benefitting cbt act month follow contrast clinician rated social avoidance found significant moderator outcome measure limitations results found month follow comprehensive measures avoidance would useful field moving forward conclusions findings inform personalized medicine suggesting social avoidance measured behaviorally via public speaking task may robust factor treatment prescription compared clinician rated social avoidance published elsevier ltd
background phenomenon deliberate self harm dsh among college students received increased attention recent decades adopting psychosocial perspective study aims describe self reported dsh among chinese medical college students assess respective associations uncertainty stress social capital dsh explore mechanism linking three phenomena methods cross sectional survey employing multi stage sampling conducted undergraduate students recruited participating chinese medical universities perceived stress uncertainty social capital assessed among students chi square test multiple logistic regression models assessed correlates dsh relationship among social capital uncertainty stress dsh examined means structural equation modeling results prevalence dsh past months among chinese students common types physical dsh reported scratching cutting pinching age chi gender chi major field chi annual household income chi statistically associated dsh uncertainty stress unique correlate dsh shows stronger association three certainty stressors social capital also strong correlate dsh especially cognitive social capital moreover social capital may indirectly associated dsh impacting uncertainty stress limitations study cross sectional thus could evaluate causal relationships conclusion recommend dsh intervention study target uncertainty stress management social capital accumulation study provides scientific evidence theoretical foundation future dsh interventions view enhancing mental health medical college students elsevier rights reserved
background agitation patients dementia increases caretaker burden increases healthcare costs worsens patient quality life antipsychotic medications commonly used treatment agitation patients dementia box warning fda elevated mortality risk electroconvulsive therapy ect made significant advances past several years efficacious treating wide range psychiatric conditions provide systematic review published literature regarding efficacy ect treatment agitation patients dementia major neurocognitive disorder methods searched pubmed medline google scholar uptodate embase cochrane literature concerning ect treating agitation dementia using title search terms ect agitation dementia ect aggression dementia ect behavior psychological symptoms dementia ect bpsd term dementia also interchanged major neurocognitive disorder time frame restriction placed attempted include publications found ensure comprehensive review found papers total patients results limited case reports case series retrospective chart review retrospective case control open label prospective study ect demonstrated promising results decreasing agitation patients dementia patients relapsed found benefit maintenance ect conclusions available studies often limited concomitant psychotropic medications inconsistent use objective rating scales short follow lack control group small sample sizes publication bias future randomized controlled trial pose ethical methodological challenges randomized controlled trial must carefully consider definition usual care comparison group well documented prospective studies additional case series explicit selection criteria wide range outcome measures less selection bias study sample may favor treatment response warranted ect may promising option treatment aggression agitation patients severe dementia refractory treatment options limitations available studies suggest cautious approach future randomized controlled trials warranted
paper propose application principal component analysis pca scale spaces pca standard method used computer vision translation input image scale space continuous operation requires extension conventional finite matrix based pca infinite number dimensions use spectral theory resolve infinite eigenvalue problem use integration propose approximate solution based polynomial equations order clarify eigensolutions apply spectral decomposition gaussian scale space scale normalized laplacian gaussian slog space application proposed method introduce method generating gaussian blur images slog images demonstrating accuracy image made high using arbitrary scale calculated simple linear combination furthermore make scale space filtering efficient approximate basis filter set using gaussian lobes approximation obtain separable filters practical example propose new scale invariant feature transform sift detector
using unified representation two current feedback operational amplifiers cfoas based sinusoidal oscillators new structures circuits type systematically discovered three catalogues three different structures structure realizing oscillator circuits presented new circuits enjoying attractive features using grounded capacitors independent orthogonal tuning frequency condition oscillation however classification independent orthogonal tuning may misleading based using barkhausen criterion therefore shown using roots characteristic equation specific oscillator circuit leading accurate results may avoid misleading conclusion regarding orthogonal tuning frequency condition oscillation experimental results using cfoa included
owning current voltage artificially controlled programmable electronic load plays essential role current future power source testing paper propose electronic load easy operate core design power control module compared result current voltage used control current nmos power transistor irf voltage two ports electronic load keyboard lcd based msp provide friendly man machine interactive interface establishing feedback network using operational amplifier maintain stability current voltage voltage follower differential amplifiers utilized sample voltage current signal moreover overcurrent protection function integrated design enhance robustness
mass taking part long distance exercises becomes current city important social phenomenon field investigation questionnaire mathematical statistics paper analyzes member behavior characteristics form zhiyuan run club weifang city members exercise independent initiative regular members overload exercise performance membership keen participate competition half members sports injuries different degree injuries mainly occurred knee ankle joints physical situation obvious difference ordinary people one hand strengthen propaganda attract city population join ranks fitness hand strengthen targeted scientific guidance group avoiding fitness misunderstanding
hiv related stigma associated many psychological challenges however minimal research explored perceived hiv related stigma intersects psychosocial issues mothers living hiv may experience including depression perceived stress social isolation present study aims describe correlates predictors hiv related stigma cohort women living hiv wlwh across ontario canada pregnancy early postpartum march december wlwh years completed study instrument measuring independent variables including sociodemographic characteristics perceived stress depression symptoms social isolation social support perceived racism third trimester months postpartum multivariable linear regression employed explore relationship hiv related stigma multiple independent variables hiv related stigma generally increased pregnancy postpartum however significant differences hiv related stigma across study time points multivariable regression depression symptoms perceived racism significant predictors overall hiv related stigma pregnancy postpartum present analysis contributes understanding hiv related stigma throughout pregnancy motherhood trajectory wlwh including interactional relationship hiv related stigma psychosocial variables notably depression racism
permeable pavement systems important part sustainable urban drainage system suds decade ago proposed pervious pavement system pps capability store water reuse possibility using suds device simultaneously source control water recycling applications holistically investigated previous studies paper reports experiments water geotextile incorporated permeable pavement system models hydrocarbon applied pollutant single dose nitrogen phosphorus potassium slow release nutrients applied encourage biodegradation administered surface pps recycled water used irrigate tomato plants lycopersicon esculentum fantasio hybrid rye grass lolium perenne ten weeks growth development heavy metal content organs plants compared plants untreated rigs plants treated ionized water well sodium adsorption ratio electrical conductivity comparative performance plants indicated water treated rigs supported plant growth water untreated test rigs heavy metal analysis plants organs indicated metals normal levels toxicity levels plants livestock soil structure tests showed salinity soil structure issues heavy metal analysis soil also indicated metals within normal range toxicity levels results demonstrate water recycling capability pps potential use irrigation purposes
horizontal partitioning traditional relational databases well studied comparison little literature partitioning nosql databases especially cloud based amazon simpledb order optimize response time web application using cloud based database possible partition database storage local regional servers work data mining cluster analysis database logs used order partition thus essentially caching data local servers work compares average response times three partitioning algorithms simple web application using cloud based nosql database management system experimental study shows techniques presented improve web application performance
fifty percent inborn errors metabolism present later childhood adulthood crises commonly precipitated minor viral illnesses increased protein ingestion many physicians consider iem common conditions sepsis considered view large number inborn errors might appear diagnosis requires precise knowledge large number biochemical pathways interrelationship matter fact adequate diagnostic approach based proper use screening tests detailed history antecedent events together simple screening tests diagnostic leading life saving targeted treatments many disorders unrecognised iem lead significant mortality morbidity advice available metabolic service based major paediatric hospital state starship children health new zealand
paper method detection megalithic barrows lidar height data presented methodology grounded joint application morphometric morphological classification digital terrain models segmentation detection circular patterns hough transform since segmentation data proposed considered geobia geo object based image analysis approach remote sensing archaeology three major strengths proposed methodology use supercomputing high performance computing analysis topographical information development specific code use accurate topographic descriptors terrain analysis method able provide concrete locations eventually match theoretical morphometric features kind sepulchres application leaded discover new barrows region western spain elsevier ltd inqua rights reserved
background purpose much discussion risk factors osteoporosis studies involving elderly population taiwan minimal aimed describe variables related osteoporosis among community dwelling older people taiwan methods cross sectional study participants randomly selected examinees annual senior citizens health examination year participants interviewed detailed questionnaire invited dual energy ray absorptiometry dxa predictor variables included age gender clinical risk factors osteoporosis main outcome osteoporosis confirmed dxa results mean age participants years old overall prevalent variables osteoporosis height loss adulthood lack dairy products calcium supplements insufficient physical activity multivariate models found underweight lack dairy products calcium supplements main variables osteoporosis subgroup analysis involving women underweight main variable discussion among community dwelling older people taiwan osteoporosis mainly associated underweight lack dairy products calcium supplements conclusion suggest using key questions underweight dietary pattern clinical settings identify high risk people candidates bmd exam elsevier rights reserved
davies gilbert work catenary notable two counts first influenced thomas telford formulating final design menai strait suspension bridge second established first time form catenary equal strength classical catenary uniform flexible chain cable hanging freely gravity supports catenary equal strength form cable whose cross sectional area made proportional tension point tensile stress uniform throughout paper provide sketch lives achievements gilbert telford interaction menai bridge follows commentary gilbert paper two related publications brief sketch earlier history catenary describe development suspension bridge present time finally discuss relations mathematical analysts practical engineers commentary written celebrate anniversary journal philosophical transactions royal society
radiation induced cardiovascular disease well described late effect cancer patients treated radiation therapy advancements surgery radiotherapy chemotherapy led increasing number cancer survivors resultant long term side effects related cancer treatments review describe short long term cardiovascular consequences mediastinal radiotherapy discuss optimal cardiovascular assessments diagnostic tools asymptomatic symptomatic patients
design defects symptoms design decay lead several maintenance problems detect defects existing research based definition rules represent combination software metrics rules sometimes enough detect design defects since difficult find best threshold values rules take consideration programming context challenging find best combination metrics alternative propose paper identify design defects using genetic algorithm based similarity distance system study set defect examples without need define detection rules tested approach four open source systems identify three potential design defects results experiments confirm effectiveness proposed approach
objective objective study examine whether participation month multimodal intervention would improve mood cognitive function adults progressive multiple sclerosis methods one arm open label feasibility trial participants prescribed home based multimodal intervention including modified paleolithic diet exercise program stretching strengthening trunk lower limb muscles neuromuscular electrical stimulation estim trunk lower limb muscles stress management meditation self massage individuals completed measures mood beck anxiety depression inventories cognitive cognitive stability index cognitive screening test delis kaplan executive function system executive function wechsler adult intelligence scale baseline months start intervention dosage multimodal intervention assessed months results individuals participated intervention activities greater improvements baseline months self report measures anxiety beck anxiety inventory bai depression beck depression inventory bdi cognitive function cognitive stability index csi delis kaplan executive function system dkefs executive function wechsler adult intelligence scale wais mood cognitive improvements closely related higher intake modified paleolithic diet exercise stress management dosage anxiety depression changes evident months whereas changes cognitive function generally observed later intervention period mood cognitive function changes baseline months significantly associated fatigue improvements conclusions modified paleolithic diet exercise estim stress management intervention like one potential improve mood cognitive symptoms lead considerable suffering people potentially improving quality life function people progressive
objective compare rates pregnancy among women underwent essure hysteroscopic sterilization versus tubal ligation france study design retrospective cohort study setting hospital care france nationwide anonymised database hospital discharge summaries france patients recruitment based procedure codes national database hospital discharge summaries study included women underwent tubal sterilization essure microinserts tubal ligation subsequently hospitalised either unexpected pregnancies related diagnosis miscarriage legal abortion delivery pregnancies following reversal microsurgery vitro fertilization ivf treatment measurements main results study period french hospitals performed tubal sterilization procedures essure sterilizations laparoscopic tubal ligations respective indication techniques depended surgeons skill median age two populations similar years range essure patients years range undergoing tubal ligation cox model performed following sterilization adjustment age essure patients became pregnant significantly lower rate laparoscopic ligation patients versus respectively pregnancy rate post sterilization procedure significantly lower reversal microsurgeries versus ivf treatment versus pregnancy rates ivf respectively tubal repair conclusion nationwide study tubal sterilization demonstrates essure associated lower rates pregnancy versus tubal ligation elsevier ireland ltd rights reserved
background andersson lesion well known complication ankylosing spondylitis recently owing worry healing fracture scholars advocated additional anterior surgery procedures necessary increase risk nerve injury purpose study introduce experience explore efficacy feasibility posterior wedge osteotomy debridement andersson lesion surgical treatment severe kyphosis ankylosing spondylitis methods january january retrospective study andersson lesion patients severe kyphosis ankylosing spondylitis treated surgery completed least year follow debridement procedure posterior wedge osteotomy posterior approach must scrape sclerosis bone healthy cancellous bone appears radiographic clinical results complications assessed average follow months scan obtained preoperatively final follow assess displacement fracture preoperatively safety screw insertion healing fracture final follow bridwell interbody fusion grading system used assess healing fracture results local kyphosis substantially corrected mean correction degrees global kyphosis changed mean vas back pain scores decreased preoperatively year follow odi score improved preoperatively year follow scan showed solid fusion level internal fixation loose patients achieved grade fusion major complication occurred conclusions posterior wedge osteotomy debridement used correct severe kyphosis ankylosing spondylitis achieving favorable clinical outcomes good fusion satisfactory deformity correction
thorium currently undergoing evaluation potential radionuclide targeted cancer therapy high chemical purity material required establish reliable procedure radiochemical isolation parent decay progeny includes radiotherapeutic performance three different separation schemes based ion exchange extraction chromatography evaluated results suggest ion exchange extraction chromatographic techniques successfully used separation decay progeny however extraction chromatographic resins demonstrate favourable performance terms recovery purification radionuclide impurities
study investigates success multiobjective genetic algorithm combined state art machine learning techniques feature subset selection fss binary classification problem bcp recent studies focused improving accuracy bcp including features neglecting determine best performing subset features however problems number features may reach thousands cause much computation power consumed feature evaluation classification phases also possibly reducing accuracy results therefore selecting minimum number features preserving increasing accuracy results high level becomes important issue achieving fast accurate binary classification multiobjective evolutionary algorithm includes two phases fss using applying techniques bcp since exhaustively investigating feature subsets intractable preferred first phase algorithm intelligently detecting appropriate feature subset uses multiobjective crossover mutation operators improve population individuals representing selected feature subset obtain near optimal solutions generations second phase algorithms fitness selected subset decided using state art techniques logistic regression support vector machines extreme learning machine means affinity propagation performance multiobjective evolutionary algorithm techniques evaluated comprehensive experiments compared state art algorithms greedy search particle swarm optimization tabu search scatter search proposed algorithm observed robust performed better existing methods datasets elsevier rights reserved
paper describes experiments conducted determine optimal implementation method aes advanced encryption standard data encryption zigbee network terms energy consumption four possible scenarios considered first one freely available aes cryptographic algorithm processor controls zigbee nodes second also involves processor based proprietary highly optimized algorithm methods based hardware implementations whereas third option based cryptographic block embedded zigbee node controller last solution utilizes aes cbc mac hardware processor embedded spartan fpga zigbee modules network contain bit microcontroller takes care zigbee protocol stack encryption calculations last case approaches examined compared show usage microcontroller board aes processor optimal design choice new hardware platform optimized software library gives best results extending existing platform paper gives developers idea amount energy gain lose choosing one four solutions copyright john wiley sons ltd
background emerging evidence suggests subset fmr premutation carriers increased risk cognitive emotional medical conditions however premutation rarely diagnosed birth early developmental trajectories children premutation known methods exploratory study examined cognitive communication social behavioral profiles infants premutation identified participation newborn screening fragile syndrome pilot study study families whose newborn screened positive fmr premutation invited participate longitudinal study early development twenty six infants premutation matched screen negative comparison babies assessed using validated standardized measures month intervals starting young months age babies assessed seven times year period results premutation group statistically different comparison group measures cognitive development adaptive behavior temperament overall communication however babies premutation significantly different developmental trajectory measures nonverbal communication hyperresponsivity sensory experiences also significantly hyporesponsive ages comparison group cytosine guanine guanine repeat length linearly associated overall cognitive development conclusions results suggest infants premutation may present subtle developmental differences young months age may early markers later anxiety social deficits challenges thought experienced subset carriers
grain refinement lath martensite bainite structures important strengthening toughening discussed various aspects strain accommodation plays important roles determine final crystal sizes bainitic ferrite martensite strong variant selection natures austenite grain boundary nucleates small undercooling variant selection leads coarse bainite block packet sizes variants formed increasing undercooling leads nucleation variants less potency increasing strength materials results self accommodation transformation strain due suppression plastic accommodation lath martensite seems similar variant selection austenite grain boundaries however packet block sizes lath martensite decreases increase carbon content extensive self accommodation due lower transformation temperatures bainite
roof tanks common low middle income countries due intermittent water supply hydraulic water mixing behaviour studied paper presents results study mixing water demand roof tanks based physical numerical models tracer tests carried real scale transparent wall laboratory model roof tank three parameter residence time distribution model applied showing model best describes mixing roof water tanks one completely stirred flow reactor small portion bypassing result confirmed computational fluid dynamic simulations visual observation instantaneous water flow derived activating typical home water using fixtures measured pipe feeding tank pipe exiting tank without roof tank stochastic water demand patterns generated measured data used numerical model small distribution network based model found water demand pipe flow behave differently continuous intermittent water supply networks instantaneous flow rate withdrawn water distribution network pipes lower systems roof tanks
new generation electrical generator sets egs based variable speed generation concept diesel engine changes speed according load set optimum speed hereby calculated according load egs optimality criterion minimum fuel consumption analysis dynamic behavior new egs concept shows new problems power voltage drops sudden increase load dynamical properties egs concept variable speed technology could improved using energy buffer solutions concept egs energy buffer advantage disadvantage discussed paper
paper presents specific dynamic extension model outlined jackson morelli political bias war american economic review particular focus implications long lived leader possesses bias towards war potentially differs country represents bargaining war outcomes characterized environment emphasize three results war sometimes occurs substantial delay possible select leader country always select leader biased towards war distribution power uneven country might select aggressive leader eventually leads country war applied context civil war model third result implies particularly disadvantaged rebel groups might select aggressive leaders bargain central government potentially incite conflict
tetris provides difficult dynamic task environment within people novices others years work practice become extreme experts study two core skills namely choosing goal objective function maximize performance feature based analysis current game board determine place currently falling zoid tetris piece maximize goal study build cross entropy reinforcement learning cerl models szita lorincz determine whether different goals result different feature weights two optimization strategies quickly rise performance plateaus whereas two others continue toward higher jagged variable heights study compare zoid placement decisions made best cerl models made human players across human game episodes two cerl models picked zoid placements lowest scoring human placements three best scoring experts placements findings suggest people focus maximizing points number lines cleared number levels reached also show goal choice influences choice zoid placements cerls suggest true humans tetris repetitive task structure makes tetris tractable like traditional experimental psychology paradigm many complex games tasks hence although complex tetris overwhelmingly complex presents right sized challenge cognitive theories especially integrated cognitive systems
population ageing global issue affects almost every country ageing researches focused demand side studies related supply side relatively scarce study selected quality enterprises focus ageing health analysed patterns providing quality services successfully study selected quality senior health enterprises explored success patterns face face semi structured depth interviews ceo enterprise thirty three quality senior health enterprises taiwan thirty three ceo enterprises interviewed individually none core values vision historical development organization structure services products provided delivering channels customer relationships development strategies results indicated success patterns senior enterprises meeting diversified lifestyles substitutive needs elderly caregivers providing total solution actual virtual integration flexible one stop shopping services classified enterprises used degree clicks mortar services residing situation elderly industry characteristics policy implications summarized observations serve primary evidenced base enterprises developing senior market also opening dialogue customers enterprises facilitate valuable opportunities creation supply demand sides
owing low scalability weak support big data insufficient data collaborative analysis inadequate situational awareness traditional methods fail meet needs security data analysis paper proposes visualization methods fuse multi source security data grasp network situation firstly data sources classified collection positions objects security data taken three different layers secondly heatmap adopted show host status treemap used visualize netflow logs radial node link diagram employed express ips logs finally labeled treemap invented make fusion data level time series features extracted fuse data feature level comparative analyses prize winning works prove method enjoying substantial advantages network analysts facilitate data feature fusion better understand network security situation unified convenient accurate mode
many implementations model based approach toroidal plasma shown better control performance compared conventional type feedback controller one prerequisite model based control availability control oriented model model obtained empirically systematic procedure called system identification model used work design model predictive controller stabilize multiple resistive wall modes extrap reversed field pinch model predictive control advanced control method optimize future behaviour system furthermore paper discuss additional use empirical model estimate error field extrap two potential methods discussed estimate error field error field estimator combined model predictive control yields better radial magnetic field suppression
paper investigate inhomogeneous reduced maxwell bloch system describes propagation intense ultra short optical pulses inhomogeneous two level dielectric medium symbolic computation integrability aspects including painleve integrable condition lax pair infinite conservation laws derived virtue darboux transformation method one two soliton solutions generated nonvanishing background including bright solitons dark solitons periodic solutions two soliton solutions asymptotic analysis method performed verify elastic interaction two solitons furthermore virtue figures dynamic properties solitons discussed results may useful study ultrashort pulses propagation situations model two level dielectric media
autism spectrum disorder asd highly heritable neurodevelopmental disorders characterized impaired social interactions communication deficits repetitive behavior although mechanisms underlying etiology manifestations poorly understood several lines evidence rodent human studies suggest involvement evolutionarily highly conserved oxytocin oxt arginine vasopressin avp neuropeptides modulate various aspects mammalian social behavior far know comprehensive review roles oxt avp systems development asd genetic aspect review summarize current knowledge regarding associations asd single nucleotide variants human oxt avp pathway genes oxt avp avp receptor avpra oxt receptor oxtr oxytocinase vasopressinase lnpep adp ribosyl cyclase
ionic polymer metal composite ipmc type smart material gained interest many researchers due ability achieve large displacements small input voltages usually less motivated use materials microsystems systems millimeter scale microgrippers however control techniques developed thus far considered feasibility using ipmcs closed loop systems without need oversized external sensors paper presents control scheme two finger ipmc microgripper accomplishes constant finger tip displacements without external sensors scheme generates displacement dependent time varying reference signal obtain constant finger tip displacements applied separate actuated ipmc actuator uses pid controller tuned model free approach gain scheduled span finger tip displacements microgripper achieves zero steady state error finger tip displacements tuned values pid controller gain scheduled pid controller tested results show zero steady state error displacements steady state error referenced deflection respectively shows great confidence validity control scheme especially tracking small reference deflections
reference treatment advanced prostate cancer pca relies pharmacological surgical androgen deprivation therapy however temporarily efficient tumor cells inevitably adapt low testosterone environment become hormone refractory hrpca observed androgen removal hrpca derived lncap cells causes different alterations homeostasis among reduction content show decrease due modest overexpression type ipr threefold increased phosphorylation ipr ser protein kinase consensus site implicated leak accordingly content restored sirna mediated regulation ipr inhibition phosphorylation competition permeant tat peptide containing ser consensus phosphorylation sequence treatment pica inhibitor moreover inhibition ipr phosphorylation methods sensitized lncap cells androgen deprivation induced apoptosis addition sercab overexpression precluded effect androgen deprivation store content reduced resistance androgen deprivation taken together results indicate lowering store content increasing ipr levels ipr phosphorylation pica protective mechanism hrpca derived cells escape cell death absence androgenic stimulation elsevier ltd rights reserved
paper presents investigation performance characterization viscous fan clutch double grooves including thermal behaviors detailed mathematical model fan clutch established taking account viscosity variation viscous fluid shear radius temperature iterative algorithm proposed calculate performances fan clutch laboratory experiments carried performance measurement setup viscous clutch validating proposed mathematical model calculation method based verified model calculation algorithm experimental setup performances six alternative viscous fan clutch designs studied combined analytical experimental results suggest clutch performances degrade increase input speed proposed model calculate method valid successfully employed facilitate design new viscous fan clutches well control system development saving cost shortening development period
date natural alkaloids mostly used field pharmacological applications active substance palmatine extensively used cancer therapy biomedical applications hence study report simple preparation poly lysine pll electro polymerized surface functionalized multiwalled carbon nanotubes mwcnt electrochemical detection palmatine content human serum urine samples active amino group pll plays vital role towards oxidation palmatine exhibits superior electrocatalytic activity optimum conditions prepared mwcnt pll composite shows wide linear response range palmatine concentration ranging detection limit lod based signal noise ratio real time monitoring palmatine content serum urine samples displays appropriate recoveries excellent performance practical analysis advantage developed system simple higher electrocatalytic activity long term stability low cost hope prepared composite opens new way fabrication different biosensors field biomedical application elsevier inc rights reserved
paper laser induced hyperthermia therapy cancer treated state estimation problem solved particle filter method namely auxiliary sampling importance resampling algorithm state estimation problems available measured data used together prior knowledge physical phenomena order sequentially produce estimates desired dynamic variables although hyperthermia treatment cancer addressed literature different computational methods usually involved deterministic analyses hand state space representation problem bayesian framework allows analyses uncertainties present mathematical formulation problem well measured data observable variables might eventually available two physical problems considered paper involving irradiation laser near infrared range non homogeneous cylindrical medium representing either soft tissue phantom skin model containing tumour region representing tumour assumed loaded nanoparticles order enhance hyperthermia effects limit effects tumour light propagation problem coupled bioheat transfer equation present study simulated transient temperature measurements used inverse analysis
little known family risk factors intergenerational transmission psychological disturbance development health anxiety study investigated related concepts year old children exposed different maternal health status using family case control design three family groups included case children mothers severe control children mothers rheumatoid arthritis control children healthy mothers children mothers completed battery standardised questionnaires case children reported significantly higher level symptoms children mothers compared children healthy mothers significant difference children self reports three groups regard anxiety symptoms general physical complaints quality life contrast mothers reported children emotional physical symptoms mothers one control groups compared mothers healthy mothers mothers also reported visits general practitioner children past year findings suggest maternal weakly affects children report thereby may strong risk factor development symptoms childhood however mothers severe seem conceive children ill present often health care system could therefore important target intervention adult patients
paper investigates role interaction communication kinesics human robot interaction study part novel research project sign language tutoring interaction games humanoid robots main goal motivate children communication problems understand imitate signs implemented robot using basic upper torso gestures sound present empirical exploratory study investigating effect basic nonverbal gestures consisting hand movements body face gestures expressed humanoid robot comprehended word participants give relevant feedback way participant passive observer active imitator throughout learning process different phases game five fingered robot platform three fingered nao robot employed within games vision sound touch motion based cues used multimodal communication robot child therapist parent within study paper presents preliminary results proposed game tested adult participants aim evaluate learning ability participants robot compare different robot platforms within setup
study formation oblique detonation waves odw non uniform ramp presented method obtaining chapman jouguet odw explored particular method discussed practical application propulsion system dual angle ramp inclined two subsequent angles overdriven supports induction oblique shock wave osw expansion wave odw conditions reaction initiation achieved across strong osw followed formation odw attached weaker osw ramp odw angles upstream flow conditions calculated analytically stoichiometric air mixture numerical simulation carried using unsteady compressible reactive flow solver openfoam detailed chemistry thermodynamics results obtained plain dual angle ramp cases compared terms combustion efficiency total pressure recovery dual angle ramp induction length significantly reduced high overdriven ramp angle despite strong induction osw near odw forms ramp section suffer higher loss total pressure combustion efficiency contributed lower odw angle decrease induction length possible dual angle ramp method allows obtaining odw required induction delay strength given upstream flow condition study proposes simple practical method obtaining near odw beneficial propulsive applications elsevier masson sas rights reserved
real time automatic regulation gene expression key technology synthetic biology enabling example synthetic circuit components operate optimal range computer guided control gene expression variety inducible promoters recently successfully demonstrated compared silico vivo three different control algorithms proportional integral model predictive control mpc controllers already used control gene expression zero average dynamics zad control technique used regulate electrical power systems chose experimental testbed commonly used inducible promoter yeast galactose responsive gal promoter set two control tasks either force cells express desired constant fluorescence level reporter protein downstream gal promoter set point time varying fluorescence tracking using microfluidics based experimental platform either glucose galactose provided cells demonstrated mpc zad control strategies successfully regulate gene expression gal promoter living cells thousands minutes mpc controller track fast reference signals better zad higher actuation effort due large number input switches requires conversely controller performance comparable achieved mpc zad controllers set point regulation
geomorphic units elementary spatial physical features river mosaic reach scale nested within overall hydromorphological structure river catchment geomorphic units also constitute template physical habitats biota assessment river hydromorphological conditions required european water framework directive wfd classification monitoring water bodies useful establishing links physical biological conditions spatial scale geomorphic units incorporating component elements hydraulic patches appropriate assess links given weakness existing methods characterisation assessment geomorphic units physical habitats lack well defined spatiotemporal framework terminology issues etc new system survey characterisation river geomorphic units needed fits within geomorphologically meaningful framework paper presents system survey classification geomorphic units gus geomorphic units survey classification system aimed characterising physical habitats stream morphology method embedded multiscale hierarchical framework analysis river hydromorphological conditions three scales geomorphic units considered macro units units sub units organised within two spatial domains bankfull channel floodplain different levels characterisation applied depending aims survey broad basic detailed level level different complementary information collected method applied combining remote sensing analysis field survey according spatial scale level description required method applicable fluvial conditions designed flexible adaptable according objectives reach characterisation assessment monitoring available data image resolution method supports integrated hydromorphological assessment reach scale morphological quality index mqi therefore contributes better establishing links hydromorphological conditions reach scale characteristic geomorphic units related biological conditions elsevier rights reserved
debate direct perception encompasses different topics one concerns richness contents perceptual experiences directly perceive low level properties like edges colors etc sparse content view perceive high level properties entities well liberal content view aim paper defend claim content perceptual experience include emotions also person impressions using examples argument developed defend liberal content view core examples social cognition view developed contrasted accounts claim case registering another person emotion seeing describe relevant content content perceptual experience perceptual belief paper defends view perceptual experiences rich content yet remain separable beliefs formed basis experience liberal enriched content perceptual experience depend upon expertise person developed field supported argument perceptual experiences systematically enriched perceiving affordances objects pattern recognition top processes analyzed processes cognitive penetration predictive coding
paper deals lack qualified professionals especially technical branches industry range possibilities spread knowledge know among students well working age population department machine design university west bohemia taken first step reach goal created interactive learning materials using projects taken real practice primarily used students university west bohemia currently materials available full time students well students hybrid courses nevertheless potential offer learning materials general public thus support amount qualified labour engineering branches west bohemian region also prospect create learning materials different branches choice made based demand would support quality education regardless original profession age handicap
objectives primary objective study assess current intrauterine device iud knowledge counseling practices obstetrics gynecology chief residents secondary objective evaluate current iud experience obstetrics gynecology residents methods web based survey iud knowledge practices sent obstetrics gynecology residents january analysis responses postgraduate year completed using descriptive statistics results received surveys pool residents different residency programs total respondents placed iud residency received formal teaching iuds residency respondents knew copper iud could used emergency contraception less respondents would routinely recommend iud adolescents immediately first trimester abortion conclusions many obstetrics gynecology residents lack knowledge iud benefits counsel eligible women use iuds continue evaluate training educational programs ensure women health providers act barrier iud use
background tenofovir tdf based regimen reported better immunological outcomes unfortunately limited information regarding immunologic outcome associated regimen ethiopia routine utilization setting begun since methods years retrospective cohort study conducted jimma university specialized hospital southwest addis ababa ethiopia total patients data september july extracted records february march records selected using simple random sampling technique data socio demographic clinical drug related variables collected entered epidata analyzed stata mixed effect linear regression performed assess difference change groups adjusting baseline characteristics change predicted count attributed regimen also assessed marginal analysis slopes random effect linear regression used indicators presence association results mean duration cohort follow days tdf azt groups respectively minimum follow duration months tdf azt groups respectively tdf azt groups completed follow tdf azt groups died tdf azt groups lost follow statistically significant difference immunologic recovery groups time predicted count tdf efv cells whereas azt efv cells conclusions tdf based regimens shown efficacy compared azt based regimens though azt based regimens affordable low income countries like ethiopia however recommend study quality design assess prevalence sub optimal response net gain cells month set among tdf users
larger larger proportions aluminium castings especially produced die casting process observed recent years automotive industry house hold articles others case automotive industry apart traditional elements produced die pressure method engine blocks crank shaft bedplates aluminium displacing steel structural parts cars body white current state development directions structural solutions cold chamber die castings analysed paper solutions drive prospective development machines die casting technology focus mainly essential functional systems hydraulic drives closing locking units well pressing die machines known companies present european market
testosterone deficiency commonly associated obesity metabolic syndrome type diabetes clinical consequences hepatic steatosis atherosclerosis testicular feminised mouse non functional androgen receptor low testosterone develops fatty liver aortic lipid streaks high fat diet whereas androgen replete littermate controls testosterone treatment ameliorates effects although underlying mechanisms remain unknown compared influence testosterone expression regulatory targets glucose cholesterol lipid metabolism muscle liver abdominal subcutaneous visceral adipose tissue testicular feminised mice displayed significantly reduced glut muscle glycolytic enzymes muscle liver abdominal subcutaneous visceral adipose tissue lipoprotein lipase required fatty acid uptake reduced subcutaneous adipose tissue enzymes fatty acid synthesis increased liver subcutaneous tissue stearoyl coa desaturase catalyses oleic acid synthesis associated insulin resistance increased visceral adipose tissue cholesterol efflux components abca apoe decreased subcutaneous liver tissue master regulator nuclear receptors involved metabolism liver receptor expression suppressed tissues except visceral adipose tissue whereas ppar gamma lower abdominal subcutaneous visceral adipose tissue ppar alpha abdominal subcutaneous testosterone treatment improved expression androgen receptor independent targets exploratory data suggest androgen deficiency may reduce buffering capability glucose uptake utilisation abdominal subcutaneous muscle fatty acids abdominal subcutaneous would lead overspill uptake excess glucose triglycerides visceral adipose tissue liver arterial walls
slender flexible characteristics make runyang suspension bridge rsb sensitive wind actions order obtain reliable statistical wind characteristics monitor wind environment bridge site two anemometers included structural health monitoring system shms collect extensive wind data paper recorded real time wind data analyzed detail acquire wind rose diagram mean wind speed direction turbulence intensity turbulence integral scale power spectral density psd three strong wind events including typhoon matsa typhoon khanun northern wind comparatively analyzed show inhomogeneous wind characteristics measured wind characteristics compared recommended values current specification china analytical results show wind speed wind direction rsb site greatly influenced subtropical monsoon climate typhoon climate traditional known rules concerning turbulence intensity proper strong winds rules validated long term monitored data meanwhile recommended values turbulence integral scale current specification suitable long term monitored wind adaptability strong wind still defective addition measured along wind spectra match generally well commonly used psds turbulence however researches still needed refine current psds turbulence perfectly satisfy measured spectrum conclusions provide references wind resistant analysis rsb structures similar areas
objective work investigation relationship mechanisms short term tensile strength creep rupture strength testing temperatures materials melting temperatures fundamental equations relating materials tensile strength creep rupture strength different temperatures structural factors obtained equations derived use phenomenological statistical thermodynamics crystalline lattice derived theoretical equation used determine creep bases experimental values short term test agreement experimental theoretical values creep demonstrated presented results applied prediction creep strength new materials particularly materials enhanced mechanical properties elsevier rights reserved
integrator configuration filter configuration method involving realization operational function edge functional circuits integrated circuit based signal flow graph desired frequency characteristics realize arbitrary linear time invariant continuous time system filter paper design procedure proposed filter integrator configuration frequency deviation small even frequency characteristic functional circuit deviates ideal one due parasitic elements circuit general integration edge feedback edge return output input signal flow graph integration edge feedback edge realized ideal lossy integrators integrated circuit hence degree freedom realization integration edge feedback proposed method degree freedom fully utilized reduce frequency deviation equation evaluate characteristic deviation parasitic elements derived parameter express degree freedom determined deviation reduced application example third order bessel filter designed numerical simulation used confirming effectiveness proposed method scripta technica
maternal nutrition vital prenatal development piglet survival around parturition may also important long term growth total multiparous sows series sows respectively fed standard gestation lactation diets supplied arginine arg isonitrogenous amounts alanine con gestation lactation weaning colostrum intake individual piglets determined based piglet birth weight weight gain duration suckling colostrum period weaning piglets weighed largest smallest pig minimum gender litter selected litters first series sows study pigs libitum fed weaning age pens comprising lit termates mixed procedure sas used estimate effects dietary treatment sex piglet colostrum intake birth weight pre postweaning growth piglet birth weight preweaning growth affected dietary treatment postweaning adg arg pigs increased compared con pigs piglet colostrum intake positively related preweaning postweaning growth piglet colostrum intake taken account conclusion long term growth performance related maternal arginine supplementation piglet colostrum intake
preprocessing step computer vision tasks research generating superpixels image widely conducted recently paper propose fully automatic superpixel generation algorithm simplifying triangle mesh modeled input image simplification performed based modified quadric error metric qem method pipeline algorithm simple given image first turn triangle mesh lift mesh based gray values image simplify mesh based modified qem method encodes features image intrinsically ensure feature aware superpixels obtaining simplified mesh map back image generate triangular shaped superpixels algorithm fully automatic number superpixels controlled intuitively experimental results demonstrate effectiveness approach
schizophrenia patients severely impaired nonverbal communication including social perception gesture production however impact nonverbal social perception gestural behavior remains unknown contribution negative symptoms working memory abnormal motor behavior thus study tested whether poor nonverbal social perception related impaired gesture performance gestural knowledge motor abnormalities forty six patients schizophrenia schizophreniform schizoaffective disorder healthy controls matched age gender education included participants completed tasks nonverbal communication including nonverbal social perception gesture performance gesture recognition tool use addition underwent comprehensive clinical motor assessments patients presented impaired nonverbal communication tasks compared controls furthermore contrast controls performance patients highly correlated tasks explained supramodal cognitive deficits working memory schizophrenia patients impaired gesture performance also demonstrated poor nonverbal social perception gestural knowledge tool use importantly motor frontal abnormalities negatively mediated strong association nonverbal social perception gesture performance factors negative symptoms antipsychotic dosage unrelated nonverbal tasks study confirmed generalized nonverbal communication deficit schizophrenia specifically findings suggested nonverbal social perception schizophrenia relevant impact gestural impairment beyond negative influence motor frontal abnormalities
paper presents comparison performances different interleaving control methods gallium nitride devices based mhz critical conduction mode crm totem pole power factor correction pfc circuit closed loop interleaving open loop interleaving good khz crm pfc mhz frequency crm pfc microcontroller mcu implementation open loop interleaving outperforms closed loop interleaving small nonamplified phase error software optimization phase error open loop interleaving smaller degrees mhz control implemented mhz low cost mcu significant ripple cancellation effect differential mode filter size reduction achieved good interleaving mhz totem pole pfc filter size reduced one quarter compared counterpart khz pfc last least stability open loop interleaving also analyzed indicating mhz crm totem pole pfc voltage mode control open loop interleaving turn instant synchronization maintain critical mode operation better stability compared khz crm pfc
multiple sclerosis leading neurological disorder young adults characterized loss oligodendrocytes ols demyelination inflammation neuronal degeneration show dynamin related protein drpl mitochondrial fission protein activated primary cells exposed tnf alpha induced inflammation oxidative stress well eae immunized cuprizone toxicity induced demyelinating mouse models inhibition drp hyper activation selective inhibitor abolishes drpl translocation mitochondria reduces mitochondrial fragmentation stems necrosis primary ols exposed tnf notably types mouse models treatment significantly reduces loss mature ols demyelination attenuates number active microglial cells astrocytes yet effect differentiation oligodendrocyte precursor cells drpl activation appears mediated ripk ripic mlkl pgam pathway tnf alpha induced oligodendroglia necroptosis results demonstrate critical role drp hyper activation cell death suggest inhibitor drpl hyper activation worth exploring ability halt slow progression elsevier inc rights reserved
peer peer self stabilizing message passing system every single node network operates independently independent resources order self stabilize correct state messages passed distributed system collectively messages passed network among member network inform nodes states later used construct complex distributed routing tables members network able communicate intelligently topology constructed passing messages take actions upon receiving messages nodes paper present analysis overhead number messages passed construction process self stabilizing linearizing algorithm overhead really give impact network especially simulation environment resources physically shared logical nodes
introduce quad tree general purpose hierarchical data structure storage multidimensional points quad trees include point quad trees trees particular cases therefore could constitute general framework study fundamental properties trees similar besides quad trees tuned means insertion heuristics bucketing techniques obtain trade offs costs time space propose three heuristics show analytically experimentally competitive performance analytical results back experimental outcomes suggest quad tree flexible data structure tailored resource requirements given application elsevier rights reserved
purpose orthorexia nervosa pathological dieting based healthy growing interest clinical data limited less half dozen case studies reporting instances medical problems due healthful eating however dozen studies using measure identify orthorexia orto report high prevalence rates non clinical samples point prevalence rates reported nearly variability could due cultural issues psychometric problems instrument study examines prevalence rate orthorexia sample method orto administered college students along questions regarding diet exercise health results orto indicated prevalence rate sample endorsed dietary practice removing particular food type meat diet endorsed following vegan diet highest less pathological mean orto score classifying participants based seriousness healthy eating whether diet led impairment everyday activities medical problems less sample fell category conclusion countries large proportion non clinical sample scored orthorexia range orto however instrument likely unable distinguish healthy eating pathologically healthful eating estimate orthorexia nervosa like anorexia nervosa bulimia nervosa common condition
basal ganglia key structures motor cognitive behavioral functions undergo several changes aging disease parkinson huntington disease example iron accumulation basal ganglia often related diseases conventionally monitored transverse relaxation rate quantitative susceptibility mapping qsm novel contrast mechanism mri produced adding information taken phase signal magnitude shown sensitive subtle changes parkinson disease order applied widely various pathologies reproducibility must evaluated order assess intra subject variability disseminate clinical pharmaceutical studies work studied reproducibility sensitivity several qsm techniques fourteen subjects scanned four times qsm images reconstructed registered atlas basal ganglia used automatically define regions interest found qsm measurements indeed reproducible basal ganglia healthy subjects widely used replacement mapping iron rich regions reproducibility study could lead several lines research relaxometry susceptibility measurements vivo iron load evaluation well pharmacological assessment biomarker development copyright john wiley sons ltd
one characteristic nondemocratic regimes leaders removed office legal means authoritarian regimes institutional way dismissing incompetent rulers available overthrowing costly anticipating people say selection leader likely resort alternative strategies limit tenure paper examine empirically strategic gerontocracy hypothesis selecting aging leaders convenient way reducing expected time office gerontocracy become likely outcome whenever leaders expected rule life test hypothesis using data political leaders period find dictators shorter life expectancies democrats time take office also observe variations life expectancies dictators selected consent average closer death seize power irregular manner finding suggests gerontocracy consequence choice process since disappears dictators self select leadership positions
paper presents three types magnetostatic models ironless planar actuators moving magnets models predict force torque exerted translator actuator positioned six degrees freedom respect stator coils force torque calculated lorentz force law analytical numerical models used design large planar actuators fast comparison actuator topologies decoupling commutation algorithm models verified experiments
elastic lattice point masses suitable representation continuous rod study longitudinal wave propagation extrapolating classical tuned mass damping strategy multimodal tuned mass damper introduced coupling two lattices modal properties aim study implement multimodal control rod coupled electrical network electromechanical analogy applied lattice gives required network energy conversion performed piezoelectric patches coupled problem modeled novel semi continuous transfer matrix formulation experimentally validated setup involving rod equipped pairs piezoelectric patches broadband efficiency multimodal control also experimentally proved vibration reductions four first resonances rod finally practical interest network pointed limits required inductance confirmed present purely passive setup involves standard low value inductors
rapid development wind power generation technology recent years caused number new problems large scale wind electricity incorporates power system one serious problems randomness volatility wind generation output grid fault may lead wind farm quit operation totally power balance system broken transient voltage stability system seriously threatened therefore quite necessary study transient voltage stability power system wind power generation incorporated mechanism transient voltage instability explained model actual electrical network large scale incorporation wind electricity total installed built bpa based electrical network model simulation design analysis carried detailed wind speed fluctuation short circuit fault two common kinds disturbances wind power integrated system study influences transient voltage stability system cases basis svc statcom two dynamic reactive compensation devices abilities system voltage supporting analyzed comparing voltage wave forms cases svc statcom configured results show cause adverse impact cases wind speed fluctuation short circuit fault wind speed suddenly increases voltage system decreases svc statcom configured power system decreasing extent system voltage reduced case wind speed suddenly changing results also show voltage supporting function obvious statcom configured svc cases single phase grounding fault three phase grounding fault fault occurs voltage system decreases svc statcom configured power system decreasing extent system voltage reduces observed dynamic reactive power compensation devices statcom greater contribution system voltage supporting effective field reactive power compensation svc
current study investigated daily light exposure relation vitality everyday settings hour hour basis method consisted experience sampling combined continuous light measurement sleep diary three consecutive days data collection distributed full year results revealed substantial inter intra individual differences hourly light exposure amount light experienced significantly related vitality indicating persons exposed light experienced vitality variance explained person characteristics time day activity patterns sleep duration previous night relationship pronounced morning darker months year participants experienced relatively low vitality previous hour overall results provide support acute effects light exposure feelings vitality daytime even everyday life elsevier ltd rights reserved
cross sectional study patients myeloproliferative neoplasms found evidence secondary osteoporosis patients essential thrombocythemia polycythaemia vera increased risk fractures underlying mechanisms settled conducted study assess bone mineral density microarchitecture estimated bone strength global bone turnover patients patients evaluated cross sectional study dual energy ray absorptiometry dxa hip spine high resolution peripheral quantitative computed tomography pqct distal radius distal tibia biochemical markers bone turnover including pro collagen type terminal pro peptide osteocalcin terminal cross linking telopeptide type collagen bone specific alkaline phosphatase also healthy comparisons matched age height weight patient included control subjects patients comparisons almost identical bmds iqr iqr respectively well microarchitecture estimated bone strength measures highly similar two groups levels bone turnover markers within reference values patients results reveal evidence secondary osteoporosis among patients mechanism behind increased fracture risk patients remains unknown
worldwide increase asthma prevalence last decades emergence vitamin deficiency many populations hinted toward underlying association two conditions since asthma presented high incidence childhood neonatal vitamin stores depend maternal vitamin levels possible programming effect maternal vitamin status gestation suggested observational longitudinal studies subject led inconclusive results glimmer positivity randomized controlled clinical trials rcts followed increased doses vitamin tested pregnant women high risk asthmatic child although results rcts showed potential association asthma related phenotypes rather asthma per low toxicity vitamin supplements make tempting speculate pregnant women high risk obtaining child asthma may benefited especially vitamin deficient
heavy metal concentrations investigated liver kidney tissues carassius carassius liver kidney tissues fish exposed routine histological process concentrations metals included determined liver kidney tissue samples using atomic absorption spectrophotometer levels liver kidney measured toxic effects heavy metals liver kidney tissues histopathological evaluation performed light microscope
starting point choosing theme belief specific professional sports instructive activity dominant form communication nonverbal communication coach athlete relationship implications improvement training process study consisted sociological approach inquiry conducted group athletes questionnaire comprised items prefigured open answers facilitate research female gymnasts vasile alecsandri university bacau team dominant form expressing sports training represented body movements expression energy information posture movement indices psycho somatic connection body soul feelings emotions expressed gestures illustration artifacts facial expressing landmarks existence nonverbal communication perceived athletes sports training process body language communication perceived respondents messages transmitted way continuous facilitating dialog coach female gymnast authors published elsevier ltd open access article license http creativecommons org licenses
alabama parenting questionnaire apq well known tool assess empirically identified aspects positive negative parenting practices study evaluates psychometric properties adapted version apq use parents children years age chile participants parents children aged years confirmatory factor analysis showed best fit obtained four factor model positive reinforcement parental involvement inconsistency disciplinary practices punitive practices invariance analysis model sex social composition positive disciplinary inconsistency punitive practices correlated externalized internalized behaviors children results suggest adaptation apq may result useful tool clinical research purposes age group
background familial mediterranean fever fmf inherited inflammatory disorder characterized attacks fever polyserositis objective purpose study evaluate pediatric patients fmf central nervous system cns findings materials methods medical records database screened retrospectively total patients fmf identified undergone neurological examination cns symptoms results neurological findings included headache patients epilepsy patients pseudotumor cerebri patients multiple sclerosis patient tremor patient common mefv gene mutation homozygous conclusions patients fmf present various cns manifestations studies include large populations needed elucidate neurological manifestations fmf
background aminopyridine food drug administration approved drug improve motor function people multiple sclerosis preliminary results suggest drug may act intact neural circuits demyelinated ones objective determine clinically relevant levels alters excitability intact motor circuits methods anesthetized rats electrodes placed motor cortex dorsal cervical spinal cord electrical stimulation electromyogram electrodes inserted biceps muscle measure responses motor responses brain spinal cord stimulation measured hours administration uninjured rats rats cut lesion pyramidal tract blood collected time electrophysiology determine drug plasma concentration goal results first determined bolus infusion optimal produced average hours infusion dose increased responses spinal cord stimulation fold uninjured rats fold rats pyramidal tract lesion responses cortical stimulation also increased fold uninjured rats fold injured conclusion clinically relevant levels strongly augment physiological responses intact circuits effect robust partial injury demonstrating broad potential treating central nervous system injuries
objective determine patients psoriatic arthritis psa achieved remission within months etanercept etn treatment without methotrexate able maintain remission months monotherapy status study duration also monitored methods post hoc analysis prove nct multicentre observational study long term adherence etn performed rheumatology clinics belgium included prove patients active psa either already receiving etn treatment recently prescribed patients achieved remission defined zero joints synovitis months etn treatment monitored maintenance remission subsequent visit addition patients etn monotherapy month observed results patients participated patients completed months etn treatment mean standard deviation sdp disease duration years majority polyarticular type psa overall patients achieved remission months etn treatment among patients remission month remained study end still remission month months patients receiving etn monotherapy majority continued month conclusion within patient population remission achieved quickly sustained long term patients receiving monotherapy continued treatment strategy duration study
paper present novel gpu based data structure spatial indexing based fenwick trees special type binary indexed trees data structure allows construction linear time updates prefixes computed logarithmic time whereas point queries require constant time average unlike competing data structures summed area tables spatial hashing data structure requires constant amount bits data element offers unconstrained point queries property makes data structure ideally suited applications requiring unconstrained indexing large data block storage large block sparse volumes finally provide asymptotic bounds run time memory requirements show applications new data structure useful
frequent human activity rapid urbanization led assortment environmental issues monitoring land cover change critical efficient environmental management urban planning current study two objectives first compare pixel based random forest decision tree classifier methods support vector machine svm algorithm pixel based object based approaches classification land cover heterogeneous landscape second examine spatio temporal land cover change last two decades using landsat data study found object based svm classifier accurate overall classification accuracy kappa value post classification change detection algorithm used determine trend change land cover classes significant change caused expansion built areas addition net changes rate annual change phenomenon calculated obtain better understanding process change average lands turned built annually annual decrease natural land current trend change continues regardless actions sustainable development drastic declines natural areas ensue results study valuable baseline land cover managers region better understand current situation adopt appropriate strategies management land cover
background interests patient health outcomes important medical students develop clinical communication skills previously proposed telehealth communication skills training platform eqclinic automated nonverbal behavior feedback medical students able improve medical students awareness nonverbal communication objective study aimed evaluate effectiveness eqclinic improve clinical communication skills medical students methods conducted group randomized crossover trial february june participants second year medical students enrolled clinical communication skills course australian university students randomly allocated complete online eqclinic training weeks group complete eqclinic training weeks group eqclinic delivered automated visual presentation students nonverbal behavior coupled human feedback standardized patient students offered two opportunities complete face face consultations sps two face face consultations conducted weeks groups rated tutors blinded group allocation student patient observed communication assessment soca collected blinded assessors time points also tutor rated clinical communications skill face face consultations primary outcome assessed soca used tests examine students performance face face consultations pre postexposure eqclinic results randomly allocated medical students groups group group soca communication skills measures score range first face face consultation significantly higher students group completed eqclinic training reviewed nonverbal behavior feedback compared group completed course curriculum components furthermore second face face assessment group completed teleconsultation two face face consultations group showed improved communication skills one teleconsultations first face face consultation group show improvement conclusions eqclinic useful tool medical students clinical communication skills training applied university settings improve students clinical communication skills development
strongyloidiasis one neglected tropical diseases caused infection nematode strongyloides genus distributed worldwide strongyloidiasis fatal immunosuppressed patients induced hyperinfection disseminated strongyloidiasis unfortunately due unspecific clinical symptom infected individuals low sensitivity diagnosis strongyloidiasis many patients misdiagnosed every year furthermore larvae strongyloides stercoralis stercoralis similar nematodes hookworm trichostrongylus increased difficulty diagnosis case patient year old male person nearly years medical history asthma emphysema year medical history diabetes sputum examination found parasite larvae identify larvae using clinical observation morphological characteristics combine examined cytochrome oxidase subunit cox rrna genes pcr sequence analysis finally classified phylogenetic analysis larvae diagnosed stercoralis results showed diagnosis strongyloidiasis morphological characteristics combine molecular biological methods improve sensitive diagnosis provide final diagnosis disease clinics
background induction treatment mild moderate crohn disease controversial purpose compare induction remission different doses mesalamine sulfasalazine corticosteroids budesonide active crohn disease data sources identified randomized controlled trials existing cochrane reviews updated literature search medline embase central november study selection included randomized controlled trials adult patients crohn disease compared budesonide sulfasalazine mesalamine corticosteroids placebo induction remission wks mesalamine budesonide stratified low high doses data extraction primary outcome remission defined crohn disease activity index score bayesian random effects network meta analysis performed proportion remission data synthesis corticosteroids odds ratio credible interval cri high dose budesonide cri high dose mesalamine cri superior placebo corticosteroids similar high dose budesonide cri effective high dose mesalamine cri sulfasalazine significantly superior therapy including placebo limitations randomized controlled trials use strict definition induction remission disease severity enrollment assess effectiveness treating mild moderate crohn disease limited conclusions corticosteroids high dose budesonide effective treatments inducing remission mild moderate crohn disease highdose mesalamine option among patients preferring avoid steroids
food allergy result life threatening anaphylaxis atopic dermatitis causes intense itching impaired quality life previous studies shown patients classical early onset tend develop food allergy adults food allergies concomitant however known whether late onset food allergy leads adult onset recently recognized disease entity using initial cohort one million subjects study retrospectively followed patients food allergy age years years compared matched controls food allergy patients developed controls developed multivariate regression analysis showed food allergy patients likely develop adjusted hazard ratio food allergy claims respectively developing adult onset first study describe chronological dose dependent associations food allergy adolescence development adult onset
consider power law entropy corrected holographic dark energy hde models hubble horizon dynamical chern simons modified gravity explore various cosmological parameters planes framework hubble parameter lies within consistent range present later epoch entropy corrected models deceleration parameter explains accelerated expansion universe equation state eos parameter corresponds quintessence cold dark matter acdm limit omega omega approaches cdm limit freezing region entropy corrected models statefinder parameters consistent acdm limit dark energy models generalized second law thermodynamics remain valid cases interacting parameter interesting mention results hubble eos parameter omega omega plane show consistency present observations like planck bao snls nine year wmap
objective disturbances circadian rhythms associated major depression may underlying mechanism disorder resynchronisation circadian rhythms may provide new approach treatment especially manipulating melatonin secretion melatonin secreted night stable marker circadian rhythms timing secretion changed exogenous melatonin agonism specific melatonin receptors suprachiasmatic nucleus suppression light sleep deprivation method part series papers chronobiology mood disorders malhi kuiper acta psychiatr scand suppl getting depression clinical practice guidelines right time change kuiper acta psychiatr scand suppl addressing chronobiology article conducted selective review studies examined antidepressant effects exogenous melatonin light therapy sleep deprivation melatonin receptor agonists results antidepressant effects identified bright light therapy especially seasonal affective disorder sleep deprivation although antidepressant effect time limited novel antidepressant agomelatine agonistic properties receptors antagonism receptor role melatonin antidepressant yet demonstrated conclusion shifting circadian secretion melatonin using strategies reviewed offers new approach treating depression
domain name system dns traffic become rich source information security perspective however volume dns traffic skyrocketing security analyzers experience difficulties collecting retrieving analyzing dns traffic response modern internet threats precisely much research relating dns negatively affected dramatic increase number queries domains phenomenon necessitated scalable approach dependent volume dns traffic paper introduce fast scalable approach called psybog detecting malicious behavior within large volumes dns traffic psybog leverages signal processing technique power spectral density psd analysis discover major frequencies resulting periodic dns queries botnets psd analysis allows detect sophisticated botnets regardless evasive techniques sporadic behavior even normal users traffic furthermore method allows deal large scale dns data utilizing timing information query generation regardless number queries domains finally psybog discovers groups hosts show similar patterns malicious behavior psybog evaluated conducting experiments two different data sets namely dns traces generated real maiware controlled environments large number real world dns traces collected recursive dns server authoritative dns server top level domain tld servers utilized maiware traces ground truth result psybog performed detection accuracy using large number dns traces able demonstrate scalability effectiveness psybog terms practical usage finally psybog detected unknown known botnet groups false positives elsevier rights reserved
introduction intimate partner violence ipv estimated affect adult women united states alone ipv directly impacts women ability use contraception resulting many unintended pregnancies stis review examines relationship ipv condom oral contraceptive use within united states two levels female victim perspective bathers condom oral contraceptive use conjunction experiencing ipv aim male perpetrator perspective regarding condom oral contraceptive use aim study design systematically reviewed synthesized publications meeting study criteria published since aimed categorize results emerging themes related study aim results identified studies met inclusion criteria found studies addressed aim within identified three themes violence resulting reduced condom oral contraceptive use condom oral contraceptive use negotiation categorized ipv due condom oral contraceptive request perceived violence fear ipv resulting decreased condom oral contraceptive use sexual relationship power imbalances decreasing ability use condoms oral contraceptives reproductive coercion found studies addressed aim studies cross sectional limiting ability determine causality ipv condom oral contraceptive use however studies find positive relationship ipv decreased condom oral contraceptive use conclusions quantitative qualitative mixed methods research demonstrated linkages female ipv victimization male ipv perpetration condom oral contraceptive use however additional qualitative longitudinal research needed improve understanding dynamics relationships ipv determine causality ipv intermediate variables contraceptive use negotiation sexual relationship power dynamics reproductive coercion condom oral contraceptive use assessing relationship ipv reproductive coercion may elucidate barriers contraceptive use well opportunities interventions increase contraceptive use forms contraception less partner influence reduce ipv reproductive coercion elsevier inc rights reserved
objective objective study determine prevalence metabolic syndrome components among pre postmenopausal women well association menopausal status materials methods retrospective study conducted reference cardiology outpatient clinic city located northwestern parana state brazil total medical records symptomatic climacteric women evaluated analyzed study consisted two groups pre post menopausal women characterized according criteria national cholesterol education program adult treatment panel iii ncep atp iii results observed total study population premenopausal women postmenopausal women displayed corresponding relative risk addition frequency increased age regarding components postmenopausal women likely high density lipoprotein hdl levels mmhg diastolic blood pressure dbp values mmhg fasting glucose levels conclusion prevalent among postmenopausal women among premenopausal women
semiconductors band gap energy levels corresponding solar energy spectrum thought great potential use electrodes produce hydrogen photoelectrochemical pec cells however many electrode designs suffer either poor stability low energy conversion efficiency limited commercialization demonstrate pec cell uses durable eutectic system consisting titanium dioxide strontium titanate active photoanode material good transport properties due high crystallinity semiconductor composite yielded photocur rents normal hydrogen electrode nhe stability testing solar irradiation boost potential photocorrosion performance competitive reported state art systems comprising titanium dioxide strontium titanate transmission spectroscopy measurements three dimensional profilometry revealed decreased reflectance increased surface area electrode analysis underlying enhanced photocurrent pec cell electrode optimization yield additional improvements energy conversion efficiency cocatalyst loading composite anatase phase instead rutile phase coupling organic dyes elsevier rights reserved
simple insightful method teach youla kucera parameterization controllers stabilize given plant presented text intended first year graduate students engineering result derived first using transfer functions state space representation stabilizing controllers naturally evolves transfer function result thus transfer functions state space techniques presented connected approaches rather isolated alternatives
exposure natural environments daylight often coincides evolutionary perspective preference highly preferred important components survival furthermore research indicated people generally positive connotations daylight nature however two phenomena mostly studied separate two different research fields article present three studies effects naturalness daylight characteristics preference studied simultaneously investigated explicit implicit preference using direct ratings scenes affective priming task respectively scenes manipulated across three dimensions naturalness nature urban brightness light dark weather type sunny overcast consistently found explicit preferences natural bright sunny scenes contrast evidence found implicit preference nature brightness sunlight elsevier ltd rights reserved
wave energy currently untapped resource potential make significant contribution energy mix order use conventional electrical generators mechanical interfaces used hydraulic systems air turbines electrical generator interfaces known electrical power take type used depends upon wave energy device brief description different power take offs provided show conventional rotary generators used wave devices advantages disadvantages highlighted paper direct drive systems overcome disadvantages additional engineering challenges overcome particular physical size mass current novel direct machine topologies discussed context challenges
background objectives describing emotional experiences using distinct terms affect differentiation associated emotion regulation adaptive behavior stress little data however examining association differentiation dispositional factors underlying psychopathology current study examines association differentiation trait anxiety given prior evidence cognitive biases relevant higher order processing emotional experiences design examined cross sectionally via lab based repeated assessment association differentiation negative positive experiences methods two hundred twenty two adults completed emotion reactivity task including repeated assessments affect hypothesized individuals higher trait anxiety hta would greater difficulty differentiating experiences results hta individuals exhibited lower levels negative affect differentiation even controlling depression although negative emotion intensity consistently associated lower differentiation account influence hta differentiation conclusions data suggest hta individuals greater difficulty differentiating negative emotions regardless negative emotion intensity depression hta common many emotional disorders evidence suggests poor differentiation may also important transdiagnostic consideration models risk affective disease
background subclinical hypothyroidism sch chronic autoimmune thyroiditis cat linked increased risk atherosclerosis coronary heart disease chd aim study look positive markers chd correlations thyroid blood tests patients sch cat symptoms chd identify chd risk conditions otherwise would likely missed methods measured series thyroid clinical metabolic cardiovascular parameters consecutive endocrinology patients enrolled ambulatory endocrinological referral center sapienza university rome cat sch january march asymptomatic subjects enrolled controls patient measured series thyroid clinical metabolic cardiovascular parameters results statistical analysis collected data oblique principal components clustering procedure opc revealed presence interesting mixed cluster composed thyroid parameter tpo metabolic parameter homocysteine level cardiovascular parameter mapse assessed relationships single components preliminary results indicate groups patients elevated tpo accompanied reduced mapse increased imt homocysteine values may taken indicate presence clinically unrecognized chd conclusions confirmation results larger series patients could justify hormone therapy prevention chd thyroid patients versus placebo treatment elsevier ireland ltd rights reserved
social categories correlating stereotypes acquired course socialization influence person perception quality social relations therefore also process trust building significant way nevertheless context trust research influence complex confounding individual characteristics multidimensional categorization processes social operations widely disregarded based differential theory trust current article captures research gap illustrates perspectives theoretical coherences research activities view actual debate intersectionality furthermore possible practical implications elucidated strategies diversity management
article consider virtual absence african voice perspective global discourses medical research ethics backdrop high burden diseases epidemics continent fact continent actually scene numerous sundry medical research studies consider reasons state affairs well situation might redressed using examples hiv aids ebola epidemics attempt show marginalization africa medical research medical research ethics deliberate rather accidental causally related general terms eurocentric hegemony derived colonialism colonial indoctrination cum proselytization end proposing seven theses critical reflection appraisal reader
paper mainly discuss software component testing interesting challenge component based software engineering cbse area first paper discuss basic concept characteristics software component brief introduction software component testing phase next part paper provide comprehensive review three proposed methods used perform software component testing
people known propensity towards false memories may considered less credible eyewitnesses therefore important investigate individual factors related susceptibility false memory development deese roediger mcdermott drm procedure involves participants remembering lists related words tendency produce critical lures words originally presented strongly related studied words considered measure susceptibility false memories participants completed drm using neutral trauma related words along measures dissociation post traumatic cognitions looming cognitive style analyses indicated dissociation related false recall traumatic stimuli higher levels post traumatic cognitions associated decrease false recognition looming cognitive style related increase confabulations decrease false recognition implications research discussed
objectives aim study evaluate whether liver stiffness measurement lsm determined transient elastography correlates presence severity liver disease children young adults cystic fibrosis methods subjects underwent lsm routine visits presence severity cystic fibrosis liver disease cfld determined clinical parameters subjects classified cfld cfld without portal hypertension phtn cfld phtn lsm compared aspartate aminotransferase platelet ratio index apri correlate severity cfld results total subjects boys mean age years years years underwent lsm subjects classified cfld cfld without phtn cfld phtn median interquartile range lsm different among groups kpa respectively pairwise comparisons different one another similarly median interquartile range apri different groups compared cfld phtn respectively analysis receiver operating characteristics discriminating cfld phtn groups resulted cut points kpa lsm apri lsm superior apri discriminating cfld phtn groups areas curve lsm versus apri conclusions liver stiffness determined transient elastography correlates presence severity cfld although apri provided information regarding severity liver disease lsm performed better apri population
despite widely reported side effects use energy drinks increased among college students report consume energy drinks help complete schoolwork however little known association energy drink use academic performance explored relationship energy drink consumption current academic grade point average gpa among first year undergraduate students participants included first year undergraduates female white students reported health behaviors via online survey measured energy drink consumption two measures past month consumption number drinks usually consumed month number consumed last occasion consumption used multiple linear regression modeling energy drink consumption current gpa controlling gender race weekend weekday sleep duration perceived stress perceived stress management media use past month alcohol use found past month energy drink consumption quantity frequency energy drinks consumed last occasion associated lower gpa energy drinks consumed last occasion consumption remained significantly associated lower gpa controlling alcohol use students report using energy drinks school related reasons findings suggest greater energy drink consumption associated lower gpa even controlling potential confounding variables longitudinal research needed addresses whether gpa declines continued use energy drinks students struggling academically turn energy drinks manage schoolwork
employees low levels work related self efficacy may stand benefit worksite stress management training smt intervention however low work related self efficacy enhanced smt benefits effect may conditional employees also high levels intrinsic work motivation present study examined proposition testing three way higher order interaction effects one hundred fifty three government employees randomly assigned smt intervention group waiting list control group smt group received three half day training sessions spread two half months findings indicated significant overall reductions psychological strain emotional exhaustion depersonalization smt group comparison control group furthermore significant higher order group smt control time work related self efficacy time intrinsic work motivation interactions reductions emotional exhaustion depersonalization certain time points experienced low baseline levels work related self efficacy high baseline levels intrinsic work motivation implications work related self efficacy theory research smt research practice discussed
computing connected dominating sets cdss widely used construct virtual backbones wireless sensor networks order control topology facilitate routing extend network lifetime constructing minimum cds hard problem cds algorithm size constructed cds usually considered important performance factor paper propose three novel algorithms construct cds wireless sensor networks algorithms intended generate small cds first algorithm performance factor optimal solution approximation outperforms existing state art approaches two algorithms variations first algorithm performance improvements include performance analysis simulation results show effectiveness algorithms reducing cds size
paper presents design development ghz schottky diode frequency doubler multiplier handle input power order increase power handling capability modeling approach incorporating computer aided design cad load pull techniques characterize diode performance proposed use approach effects several critical diode parameters power handling issue quantitatively investigated based analysis discrete diode chip designed doubler ensure rapid heat sink doubler circuitry low cost aluminum nitride ceramic aln selected dielectric material circuit substrate significantly better thermal conductivity compared currently widely used fused quartz doubler circuitry based balanced configuration brings merit avoiding use filter input output signal isolation doubler circuit optimized simulation using ansys hfss keysight ads measurements show doubler handle input power power conversion efficiency nearly resulting output power ghz
compared results modified version asthma control test using parent proxy report act results reported children parents using validated childhood asthma control test act parent child dyads child aged years asthma randomized complete act followed act act followed act scores indicated uncontrolled asthma calculated sensitivity specificity positive predictive value negative predictive value act comparison act calculated concordance scales act sensitivity negative predictive value detecting uncontrolled asthma surveys concordant kappa moderate agreement results suggest act missed children uncontrolled asthma may simplify reporting asthma control circumstances child report feasible creates barriers survey receipt limitations proxy reporting considered
geotextile tubes hydraulically mechanically filled dredged materials successfully applied hydraulic coastal engineering recent years shore protection structures sea dikes groins jetties detached breakwaters method becoming popular widely applied developed countries world economical well useful enables store isolate contaminated materials obtained harbour dredging study numerical analysis performed investigate behaviour geotextile tubes terms various properties material shape condition pumping pressure computer program geocops employed analysis also field tests conducted order identify construction workability saemangeum inner dike geotextile tube method applied field tests geotextile tubes length diameter used field tests found geotextile tubes filled diameter unfilled theoretical one might reach approximately theoretical diameter time effective height geotextile tube behaviour construction measured confirm construction method workability ended successful identification copyright john wiley sons ltd
objective previous study conducted group found theory mind tom differences preschool children sustained mild traumatic brain injury mtbi compared typically developing peers months postinjury goals current longitudinal study determine whether findings result brain injury specific effect rather general injury effect examine long term evolution tom skills following preschool mtbi well investigate links tom abilities general social functioning method seventy two children sustained mtbi ages months evaluated months postinjury tom tasks including desires emotions reasoning false belief understanding compared participants sustained orthopedic injury typically developing children tdc results groups differ demographic baseline characteristics mtbi group obtained poorer scores relative comparison groups desires emotions reasoning task months injury correlations found injury characteristics tom performance mtbi group associations found tom performance global social competence conclusion findings suggest brain injury specific effect persists long term following mtbi preschool children
heisenberg type models spin spin interactions used explain magnetic ordering ferromagnetic materials paper generalized inhomogeneous nonlinear schrodinger equation heisenberg ferromagnetic spin system investigated virtue generalized darboux transformation higher order rogue wave solutions derived wave propagation interaction analyzed bright rogue waves found perturbation parametes inhomogeneities medium system affect direction existing time first order rogue wave propagation perturbation parameters inhomogeneities medium system affect shapes distances patterns existing times second third order rogue wave interactions direction second order rogue wave remains unvaried interaction
construction demolition wastes increasingly reused civil engineering applications mainly concrete production base layers roadway infrastructures however frequently fine grain portion recycled aggregates considered suitable applications landfilled instead recycled moreover value added utilisation recycled construction geosynthetic reinforced structures steep slopes retaining walls almost unexplored field research assesses feasibility using fine grain recycled filling material geosynthetic reinforced structures grs appraising physical mechanical environmental characterization construction demolition material well direct shear pullout behaviour interfaces material three distinct geosynthetics two geogrids one geocomposite reinforcement high strength geotextile direct shear tests results shown fine grain recycled properly compacted exhibit similar shear strength natural soils used commonly construction grs potential contamination groundwater recycled evaluated laboratory leaching tests excepting values sulphate total dissolved solids tds recycled complies provisions european council decision inert materials high values coefficients interaction geosynthetic interfaces parameter utmost importance design performance grs achieved results herein presented support viability using recycled filling material grs construction elsevier ltd rights reserved
background elementary school students world iranian students use backpacks heavy school bags failure apply ergonomics standards student backpacks also mismatch anthropometrics dimensions schoolbag size important issues children health objective purpose study gather baseline information average weight carried female primary students also aimed evaluate ergonomics standards student backpacks methods cross sectional study conducted iranian girl students aged years body weight bag weight measured electronic scales body mass index calculated software questionnaire constructed gather information backpacks body dimensions measured vicon motion analyze system ergonomics factors recorded using checklist results students used backpack higher weight recommended standards body weight common type schoolbag used double strap packs majority students carried packs backs however make adjustments results shown mismatch anthropometric measures student backpack dimensions conclusions parents students school staff informed critical issues well suitable controls implemented buying using bags
order achieve successful results control courses multidisciplinary audience high abstraction layer programming required abstraction provided custom developed rapid control prototyping system enables usage model based design techniques control real plants model based design focused research development control algorithm system identification plant modelling usage proposed embedded rapid control prototyping system eliminates completely need low level input output control hardware configuration debugging making system capable used intended multidisciplinary audience since model based design focuses design analysis techniques shows relationships control theory real controller implementation issues several controllable real plants ready used students bachelor master thesis degrees come many engineering fields including mechanical electrical also common drawbacks commercial rapid control prototyping systems avoided thanks customized low cost rapid control prototyping system presented article
neurosteroids essential aiding proper fetal neurodevelopment pregnancy compromises preterm birth prenatal stress intrauterine growth restriction associated increased risk developing behavioural mood disorders particularly adolescence pathologies involve premature loss alteration trophic steroid hormones reaching fetus leading impaired neurodevelopment specific programming mechanisms yet fully elucidated adult life dysfunctions allopregnanolone action prevalent individuals depression post traumatic stress disorder anxiety disorders objective study assess changes concentrations neurosteroid allopregnanolone may fetal programming factor priming brain towards negative behavioural phenotype childhood adolescent period using guinea pig model pregnant guinea pigs received either vehicle hydroxypropyi beta cyclodextrin alpha reductase inhibitor finasteride maternal weight gestational age spontaneous delivery similar days gestation male female offspring vehicle finasteride treated dams tested postnatal day juvenile equivalence open field arena hippocampus amygdala subsequently assessed neurological changes markers development gaba production pathways later females reduced allopregnanolone exposure utero displayed increased neophobic like responses change environment compared female controls differences neurodevelopmental markers assessed map neun mbp gfap gad intrauterine finasteride vehicle exposure either hippocampus amygdala whereas gat staining decreased study indicates intrauterine reduction supply allopregnanolone programs vulnerability female offspring anxiety like disorders juvenility without impacting long term allopregnanolone concentrations isdn published elsevier ltd rights reserved
objective compare prevalence coronary heart disease chd effects various risk factors including alcohol consumption prevalence rates randomly selected sample older hispanic non hispanic white nhw men women design setting cross sectional study equal numbers hispanic nhw men women selected randomly health care financing authority medicare rolls recruited home interview followed hour interview examination senior health clinic participants total volunteers mean age years interviewed examined measurements chd identified interview electrocardiogram risk factors identified interview hypertension diabetes medications smoking alcohol consumption direct measurements glucose tolerance serum lipids blood pressure anthropometry results age adjusted prevalences chd significantly different hispanic men women compared nhw counterparts age ethnicity gender adjusted relative risk chd inversely associated alcohol consumption hypertension diabetes mellitus male gender also significant risk factors age anthropometric measurements smoking serum lipid concentrations level education hdl cholesterol levels significantly lower nondrinkers lipid levels associated alcohol consumption type alcoholic beverage associated prevalence chd conclusions significant differences chd prevalence existed hispanic nhw participants despite higher prevalence diabetes central obesity hispanics alcohol consumption strongly negatively associated prevalence chd identified older biethnic population
prenatal hypoxia induces structural functional disturbances brain develop following postnatal ontogeny cognitive behavioral disorders induced prenatal hypoxia preserved even adults oxidative stress key factor damage hypoxia hence relationship pro antioxidant systems plays important role development pathological adaptive processes induced hypoxia using immunocytochemistry studied expression four endogenous protein antioxidants superoxide dismutase superoxide dismutase thioredoxin thioredoxin hippocampal neurons adult rats subjected triple hypoxia days prenatal development found number cases prenatal hypoxia substantially modified expression endogenous antioxidants hippocampal neurons rats achieved adult age days postnatal ontogeny directions changes however different different antioxidants areas hippocampus seems multidirectionality changes expression different antioxidants different areas reflects inextricable connection pathological consequences prenatal hypoxia adaptation processes induced hypoxia
background bipolar disorder schizophrenia show substantial overlap suggested subgroup patients might contribute overlapping features study employed cross diagnostic cluster analysis identify subgroups individuals shared cognitive phenotypes method participants patients patients healthy controls completed battery eeg performance assessments perception nonsocial cognition social cognition means cluster analysis conducted participants across diagnostic groups clinical symptoms functional capacity functional outcome assessed patients results two cluster solution across groups stable one cluster including patients controls patients showed better cognition high cluster cluster patients patients controls low cluster patients high cluster performed better patients low cluster across cognitive domains within cluster participants different clinical diagnoses showed different profiles across cognitive domains limitations patients chronic phase mood episode time assessment assessment behavioral measures conclusions study identified two clusters shared cognitive phenotype profiles proxies clinical diagnoses finding better social cognitive performance patients patients lowe cluster suggest relatively preserved social cognition may important identify disease process distinct disorder
high concentrations fluoride body may cause toxic effects investigated effects fluoride structure function proteome cortical collecting duct epithelium vitro kidney tubule cells chosen concentration fluoride kidney fold higher plasma mouse cell monolayers incubated fluoride containing media amiloride sensitive short circuit current transepithelial resistance measured young modulus epithelium determined using atomic force microscopy effect fluoride epithelial structure assessed using scanning transmission electron microscopy immunofluorescence differences expression membrane proteins evaluated using proteomics bioinformatics fluoride exposure reduced transepithelial transport resistance fluoride approximate effects half times decays ion transport resistance days respectively fluoride treatment affect sensitivity transport amiloride young modulus epithelium also unaffected fluoride however functional effects fluoride accompanied marked structural effects proteomic analysis revealed changes expression number proteins particularly mitochondrial proteins treatment fluoride profound effects structure function proteome model cortical collecting duct epithelium significantly however effects produced concentrations considerably higher likely encountered vivo wiley periodicals inc environ toxicol
theory three way decisions consider decision making problem ternary classification one realized acceptance rejection non commitment recently theory integrated formal concept analysis two different ways constructive axiomatic methods constructive method define certain three way concepts formal context support three way concept analysis axiomatic one characterize general three way concepts axioms perform three way concept learning nevertheless similarities constructive axiomatic methods fact three way concept analysis induced constructive method three way concept learning induced axiomatic one realized incorporating idea ternary classification design extent intent concept however information fusion abilities need improved since neither able deal large multi source data effectively motivated problem paper reconsider three way concept learning based cognitive operators perspective information fusion parallel computing techniques learning three way concepts developed large multi source data specifically large data relationship global granular concept local ones first clarified employed design information fusion algorithm multi source data whole evaluation function used induce three way decisions established aggregating results obtained single source data three way concept learning made constructing lower upper approximation concepts finally conduct numerical experiments evaluate effectiveness proposed parallel computing algorithms elsevier inc rights reserved
cultural issues tied race ethnicity important aspects delivering medical home services children neurodevelopmental disabilities families better understand family satisfaction family centered care fcc medical homes children disabilities study investigated whether family race ethnicity addition parent child characteristics significantly influenced family perceptions fcc three areas family provider partnership care setting practices policies community coordination follow based life course theory optimizing children developmental trajectories examining connections family race ethnicity satisfaction health care allows identification strengths weaknesses medical home services delivery offers opportunities family support improvement outcomes children disabilities study developed original empirical survey using structured questionnaire developed family voices national advocacy organization dedicated promoting well children disabilities families study collected data families large urban area northeastern united states multivariate analyses revealed family race ethnicity significantly contributed prediction parental satisfaction medical homes children disabilities families perceptions fcc care setting practices policies community coordination followup family provider partnership non white families reported significantly lower satisfaction discussion emphasizes health care providers need become vigilant providing culturally sensitive care enhance fcc practices policies study advances checklist ten essential areas promote culturally sensitive interactions families children disabilities medical non medical health care providers
background medical stabilization inpatient nutritional rehabilitation often necessary patients eating disorders eds includes inherent risk refeeding syndrome describe experience implementing sustaining inpatient nutritional rehabilitation protocol designed strategically prepare patients eds families discharge home setting efficient effective manner general adolescent medicine unit report outcomes admission discharge weeks follow methods protocol development implementation unique features protocol described data collected retrospectively part continuous quality improvement initiative safety outcomes clinical need phosphorus potassium magnesium supplementation evidence refeeding syndrome unexpected readmissions within one month discharge value outcome length stay los treatment outcomes percentage median bmi mbmi change admission discharge discharge weeks follow visit results total patients included patients averaged years old atypical anorexia atan bulimia nervosa purging disorder avoidant restrictive food intake disorder arfid unspecified food eating disorder ufed average los days initial mean calorie level patients admission discharge kcals day phosphorus supplementation refeeding hypophosphatemia needed inpatients full threshold refeeding syndrome occur rehospitalized thirty days discharge patients averaged median mbmi age gender mbmi discharge mbmi weeks follow mean percentage mbmi differences time points significantly different admission discharge discharge follow conclusions implementation chop inpatient nutritional rehabilitation protocol aimed rapid efficient safe weight gain integration caregivers treatment patients diverse diagnoses led excellent outcomes percentage mbmi discharge weeks follow maintaining short los low rates phosphorus supplementation
rapid development micro electro mechanical devices demands micro power generation systems significantly increased recent years traditional chemical batteries energy densities much lower hydrocarbon fuels makes internal combustion engine attractive technological alternative batteries micro rotary internal combustion engine drawn great attractions due planar design well suited fabrication mems paper phenomenological model considering heat transfer mass leakage developed investigate effects engine speed compression ratio blow heat transfer performance micro rotary engine provide guidelines preliminary design rotary engine lower possible miniaturization limits rotary combustion engines proposed elsevier ltd rights reserved
article considers delillo point omega tacit response violence assumes aura catholic mystery novel delillo screens violence view critique replayed screen media violence fanatical fundamentalist terrorism thus reinvigorates novelist visionary rhetorical force fosters contemplation via questions advocates compromise rather extremism
bobbin tool friction stir welding btfsw relatively new solid state welding technology control conventional friction stir welding fsw due unique welding tool structure paper closed loop control system developed smith predictive proportional integral derivative pid control method presented assist welding system producing appropriate interface temperature response difficult accurately detect temperature full range welding zone tool workpiece interface temperature detected thermocouple wireless transmission technology initial experiments conducted derive qualitative understanding bobbin tool friction stir welding processes ziegler nichols setting method adopted determine parameters pid controller examining capabilities smith predictive pid control btfsw paper focuses control effect hysteretic characteristics welding temperature butt welding compensation strategy setting gaps along welding path gap could affect distribution temperature experiments demonstrate temperature control strategy feasible tensile properties weld uniform along welding direction
objective transmitral blood flow produces vortex ring quantified using vortex formation time vft enhances efficiency left ventricular filling vft attenuated hypertrophy resulting aortic valve stenosis versus normal geometry many patients also aortic insufficiency authors tested hypothesis moderate falsely elevates vft partially inhibiting mitral leaflet opening patients design observational study setting veterans affairs medical center participants patients presence absence moderate per group undergoing aortic valve replacement avr studied institutional review board approval interventions none measurements main results general anesthesia peak early filling atrial systole blood flow velocities corresponding velocity time integrals obtained using pulse wave doppler transesophageal echocardiography tee determine atrial filling fraction beta mitral valve diameter calculated average major minor axis lengths obtained midesophageal bicommissural transcommissural anterior lateral posterior medial long axis anterior posterior tee imaging planes respectively vft calculated beta stroke volume measured using thermodilution hemodynamics diastolic function vft determined steady state conditions cardiopulmonary bypass severity mean peak pressure gradients peak transvalvular jet velocity aortic valve area diastolic function beta similar groups moderate centrally directed present patients ratio regurgitant jet width outflow tract diameter pulse pressure mean pulmonary artery pressure elevated patients versus without differences hemodynamics observed mitral valve minor major axis lengths diameter area reduced presence versus absence vft increased significantly patients compared alone conclusion moderate falsely elevates vft patients severe undergoing avr partially inhibiting mitral valve opening vft may unreliable index filling efficiency competitive diastolic flow published elsevier inc
background although anti egfr monoclonal antibody panitumumab effective treating colorectal cancer occurrence severe skin disorders often discontinues therapy herein investigated retrospective chart review effect prophylactic oral minocycline combination skin treatment using moisturizer incidence skin disorders tumor response metastatic colorectal cancer patients received panitumumab patients methods total patients patients eligible consisting pre emptive group reactive group acneiform rash adverse events graded according ctcae results occurrence acneiform rash grade significantly lower pre emptive group reactive group significant differences occurrence adverse events observed two groups tumor response significantly different two groups confidence interval mean time treatment failure days days pre emptive group reactive treatment group respectively conclusion prophylactic oral minocycline combined skin care reduced panitumumab induced acneiform rash without significant influence tumor response
ultrasound rapidly advancing field many emerging diagnostic therapeutic applications diagnostics new vascular targets routinely identified mature technologies translated humans recent innovations may bring creation acoustic reporter genes micron scale resolution ultrasound cancer therapy ultrasound explored adjuvant immune therapies deliver acoustically thermally active drugs tumor regions ultrasound enhanced delivery across blood brain barrier bbb could potentially impactful brain cancers neurodegenerative diseases bbb often impedes delivery therapeutic molecules minireview provide overview topics field ultrasound especially relevant interests world molecular imaging society
aim evaluate efficiency interferon ifn therapy patients essential thrombocythemia polycythemia vera subjects methods total patients examined prior study enrolment patients received one therapy aspirin taken account mean jakvf mutant allele baseline patients median time diagnosis enrollment months results paper presents clinical molecular findings long term inf alpha therapy patients median follow months recombinant ifn alpha showed ability induce complete hematologic remission complete molecular response patients noted smaller number cells jakvf mutation patients relative reduction proportion cells jakvf mutant gene averaged baseline values respectively reduction proportion cells expressing jakvf mutation groups ten patients achieved deep molecular remission jakvf allele among patients found jakvf mutation obtained molecular response remained patients untreated months long term treatment ifn alpha led normalization morphological pattern bone marrow patients conclusion significant molecular remissions achieved therapy recombinant interferon alpha confirm appropriateness treatment option majority patients
discrete time signal processing receivers combine gain conversion anti aliasing sampling filtering offset compensation one analog block reduce size solution paper presents analog front end afe single chip gsm gprs edge gge radio digital cmos based discrete time analog signal processing heart afe passive switched capacitor stages providing gain boosting impedance transformation providing order filter response afe achieves dbm iip filter occupies boolean consumes
plasmablastic lymphoma rare entity accounting around aids related lymphomas oral cavity gastrointestinal tract common sites involved report case year old hiv positive woman rare presentation cutaneous nodules body due overwhelming tumour burden developed tumour lysis syndrome hospital stay succumbed illness
particle selectivity sediment deposited vegetative barriers importance predict sediment transport particulate pollutant load surface waters grassed barriers covers degrees slope subjected silt laden inflows presence absence simulated rainfalls investigate sediment deposition processes results show regrass steep croplands effectively trap eroded sediment upslope rowed grass barriers strengthen sediment deposition deposition order sediment particle sizes follows particle selectivity weakens increasing grass covers clay particles similar deposition efficiency overall sediment implying effectiveness regrass controlling soil nutrient loss contribution grass total overland flow resistance almost equivalent percentage grass cover steep grassed slopes raindrop impact significantly decreases sediment deposition limitedly affects particle selectivity deposited sediment overland flow hydraulics raindrop kinetic energy stream power available surface soil contribute sediment deposition net deposition areas grass barriers imply rainfall effect sediment delivery vegetated barriers derives additional raindrop energy rather variation runoff hydraulics results help clarify effect raindrop impact sediment transport evaluate benefit revegetation decreasing sediment yield particulate nutrient load surface waters
virtual reality technology kind cross integration computer technology developed basis multiple disciplines computer graphics sensor technology computer simulation display according applications virtual reality technology present ancient cavern ancient cavern protection scheme based virtual reality technology proposed paper takes cuiguangyan ancient caverns important part longyou grottoes example virtually reappear damaged area cuiguangyan ancient caverns spatial environment existed history provides basis protection development ancient caverns cuiguangyan beneficial attempt application virtual reality technology ancient cavern protection
benthic streambed biofilms metabolize substantial fraction particulate organic matter nutrient inputs streams microbial communities comprise significant proportion overall biomass headwater streams present primary control transformation export labile organic carbon biofilm growth linked enhanced fine particle deposition retention feedback confers distinct advantage acquisition utilization energy sources quantified influence biofilm structure fine particle deposition resuspension experimental stream mesocosms biofilms grown identical recirculating flumes periods days obtain range biofilm characteristics fluorescent particles introduced flume concentrations water column monitored min period measured particle concentrations using flow cytometer mesoscale biofilm structure using optical coherence tomography particle deposition resuspension dynamics determined fitting results stochastic mobile immobile model showed retention timescales particles within biofilm covered streambeds followed power law residence time distribution particle retention times increased biofilm areal coverage biofilm roughness mean biofilm height findings suggest biofilm structural parameters key predictors particle retention streams rivers
sought examine trends cigarette smoking identify correlates smoking examine impacts smoking health related quality life hrqol among people living hiv ontario canada study sample included individuals receiving care enrolled ontario hiv treatment network cohort study self report data cigarette smoking hrqol demographic sociobehavioral variables collected annual face face interviews clinical data abstracted participants medical records enhanced linkage provincial public health laboratory database analyses included descriptive statistics generalized logit regression linear mixed effects modeling first interview participants current cigarette smokers smoking prevalence declined annually remained much higher prevalence general population current cigarette smokers likely younger male white indigenous canadian born single unemployed lower education heavy drinkers nonmedicinal drug users current depression former cigarette smokers never smoked current cigarette smokers also significantly worse physical component summary beta mental component summary beta scores never smoked adjusting demographic socioeconomic hiv related clinical variables reduce burden cigarette smoking cessation interventions take account complex social economic medical needs people living hiv needed urgently
deregulated power system congestion management major problem due operational constraints flexible transmission systems facts devices choice control power flow congested lines paper explores use two popular facts devices tcsc statcom power flow control electrical network capability decongest network suggests optimal location tcsc statcom individually relieve congestion minimum power losses voltage regulation cost device proposed method verified ieee bus system effectiveness simulation work carried matlab software
purposeidentifying atrial fibrillation outpatients treated oral anticoagulants oacs claims databases challenging outpatient indication available oacs also prescribed deep vein thrombosis pulmonary embolism dvt may treated ambulatory setting algorithm developed identify outpatients initiating oac medico administrative data methodsamong patients initiating oac french healthcare databases treated orthopaedic indications excluded patients history dvt directly identified available medical data mainly hospital discharge diagnoses considered confirmed dvt patients demographics patients healthcare utilization data prior oac initiation included logistic regression model discriminating versus dvt indications final model selected comparing index provided algorithm identifying among initially unclassified patients assumed either dvt outpatients resultsamong patients initiating oac excluded dvt patients directly identified leaving unclassified patients final model index included demographics cardiologist prescriber hospitalization stroke use antiarrhythmics beta blockers antihypertensive drugs undergoing holter echocardiography procedure thyroid function tests dimer tests specificity sensitivity unclassified patients assumed outpatients similar results obtained new users conclusionthis algorithm combining inpatient outpatient claims data performed relatively well identify outpatients initiating oac copyright john wiley sons ltd
introduction high grade renal injuries american association surgery trauma aast grades iii result motor vehicle collisions associated numerous concomitant injuries sportsrelated blunt renal injury tends different mechanism solitary blow flank hypothesized high grade renal injury often isolated sports related renal trauma material methods identified patients aast grades iii blunt renal injuries four level trauma centres across united states patients divided sport non sport related groups outcomes included rates hypotension systolic blood pressure bpm concomitant abdominal injury procedural surgical intervention sports non sports related injury results patients met study criteria sports related injuries common mechanisms skiing snowboarding contact sports respectively median age years sports years non sports related renal injuries males commonly involved sports related injuries median injury severity score lower sports related injuries difference renal abbreviated injury scale scores sports related trauma likely isolated without significant injury haemodynamic instability present sports non sports renal injuries sports injuries lower transfusion lower mortality rates difference renal specific procedural interventions two groups sports non sports conclusions high grade sports related blunt renal trauma likely occur isolation without abdominal thoracic injuries clinicians must high suspicion renal injury significant blows flank sports activities elsevier ltd rights reserved
pegylated interferon peg ifn proven phase trials effective polycythemia vera however clear whether could improve patient outcome compared hydroxyurea present observational study patients aged years younger received either peg ifn according physician choice median follow months two cohorts comparable patient disease characteristics eighty seven percent patients treated peg inf responded rate compared respectively discontinuation rate similar two groups peg ifn jak allele burden monitored peg inf arm reduction observed patients thrombotic events observed peg ifn treatment compared three disease progression myelofibrosis acute myeloid leukemia occurred patient peg inf compared three overall three second malignancies observed study two patients received one patient largely treated received also peg ifn months overall survival significantly better peg ifn patients compared study albeit limited small patient event number lack randomization confirms efficacy peg inf shows significant survival advantage peg inf treated patients waiting confirming data ongoing phase iii trials study support peg inf first line treatment option least younger patients
paper proposes optimal tuning proportional integral derivative pid controller using bacterial foraging optimization algorithm bfoa enhance control performances stability automatic voltage regulator avr system new objective function designed necessary time domain specifications considered research work tuning gain parameters pid controller effectiveness proposed bfoa tuned pid controller extensively absorbed analyzing output performance stability robustness system superiority proposed approach distinctly demonstrated comparing results recently documented results swarm intelligence techniques differential evolution particle swarm optimization pso artificial bee colony abc algorithms many optimizing liaisons mol algorithm
paper propose new graphics processing unit gpu method able compute constrained delaunay triangulation cdt planar straight line graph consisting points segments existing methods compute delaunay triangulation given point set insert segments finally transform resulting triangulation cdt contrary novel approach simultaneously inserts points segments triangulation taking special care avoid conflicts retriangulations due concurrent insertion points concurrent edge flips implementation using compute unified device architecture programming model nvidia gpus improves terms running time best known gpu based approach cdt problem
important model reaction photocatalytic methanol dissociation rutile tio drawn much attention reaction mechanism remains elusive using dft calculations investigate whole dissociation process methanol formaldehyde without photogenerated holes aiming illustrate hole involved dissociation find dissociation methanol heterolytic cleavage process likely thermally driven presence hole promotion barrier enthalpy change contrast subsequent bond cleavage follows homolytic cleavage mode likely photochemically driven great enhancement made kinetics thermodynamics holes introduced essential roles holes promoting dissociation identified kinds catalytic reactions facilitated holes discussed findings may considerably broaden understanding photocatalytic chemistry
tool condition monitoring fundamental part manufacturing industry similar automation hence great importance research based manufacturing engineering many people concern manufacturing industries interestedly study tcm successful unmanned automation production possible presence good tool wear monitor tool breakage detection system reliability production system increased significantly tool wear also affect quality surface finish work piece dimension manufactured parts decides quality final product need raised quite large interest among researchers frequent users learners tool condition done employing various methods able give successful result due complexity parameter variation machining process globally accepted studied used worldwide paper concerns useful efficient methods tcm tool condition monitoring integrated approach tool condition monitoring control together data acquisition different parameters proposed inspect tool wear condition different sensors used signal measurement
micrornas mirnas play key roles regulating toxicity tolerance plants solanum torvum typical low accumulating plant high tolerance despite importance mirna identified torvum thus far study high throughput sequencing torvum small rnas used identify mirnas differentially expressed response toxicity least mirna families individual members within families identified control treated torvum roots among mirnas mirnas mirna families differentially expressed control treated torvum plants among differentially expressed mirna families mirna families upregulated treated roots mirna families downregulated treated roots bioinformatics analysis indicated mirnas involved replication recombination repair inorganic ion transport metabolism transcription signal transduction mechanisms cell cycle control cell division chromosome partitioning rna processing modification torvum roots results indicated specific mirnas tightly regulated toxicity roots torvum may play key roles tolerance torvum
important know residual fatigue strength materials extremely low cycle fatigue elcf regime order assess structural integrity large cyclic strain caused earthquake elcf regime pointed surface cracking also additional bulk damage reduces fatigue life study fatigue strength stainless steel low cycle elcf regimes effects bulk damage fatigue strength investigated type stainless steel subjected axial cyclic strain strain amplitude also change fatigue life investigated surface layer specimens removed fatigue tests shown surface cracking also bulk damage affected fatigue life also shown bulk damage consisted two factors internal cracking local damage internal cracks observed fractured surface strain amplitude cases specimen fractured internal cracks local damage reduced incubation period crack initiation fatigue life decreased strain amplitude increased cases experiment conducted strain amplitude epsilon neither internal cracks local damage affected fatigue life elsevier ltd rights reserved
lead zirconate titanate pzt microwires applications sensors actuators energy harvesters produced using hydrothermal synthesis synthesized microwires relatively large average length microns average width microns individual pzt microwires integrated smart systems active phase used independent smart material paper synthesis procedure characterization large microwires demonstrated converse piezoelectric properties microwires measured using digital image correlation clamping adding electrodes end microwire shown literature digital image correlation used precise tool rapid characterization piezoelectric materials demonstrated technique applied characterize actual response piezoelectric materials micron scale
poster details within subjects study investigating effects vibrotactile stimulation illusory self motion presence perceived realism interactive sandboarding simulation study compared three conditions vibration constant vibration dynamic vibration results suggest constant vibrotactile feedback led significantly compelling self motion illusions higher degree perceived realism
general purpose computing gpus emerging new paradigm several fields science although far applications tailored employ gpus accelerators offline computations steady decrease gpu latencies increase link memory throughputs time ripe real time applications using gpus high energy physics data acquisition trigger systems discuss use online parallel computing gpus synchronous low level trigger systems focusing tests performed trigger cern experiment latencies components need analysing networking critical keep control envisioned nanet fpga based pcie network interface card nic enabling gpudirect connection moreover discuss specific trigger algorithms parallelised thus benefit gpu implementation terms increased execution speed improvements particularly relevant foreseen lhc luminosity upgrade highly selective algorithms crucial maintain sustainable trigger rates high pileup elsevier rights reserved
gender especially status women certainly one salient identities corners world countries issues begin right education even earliest ages united states prevailing assumption women majority undergraduate graduate populations higher education threshold concerning access equity reached story gender however complex one article focus parallel notions significant progress domains women higher education paradox depending level depending women progress cases lack progress clear article review changes last decades address deeper issues institutional transformation emerging issues policy including conceptualizations gender
letter generalized nonlinear schrodinger maxwell bloch system investigated used describe solitons optical fibers virtue generalized darboux transformation higher order rogue wave solutions derived rogue wave propagation interaction analyzed complex envelope field appears bright rogue wave measure polarization resonant medium bright dark rogue wave extant population inversion eta dark rogue wave group velocity inhomogeneity linear kerr nonlinearity inhomogeneity affect eta parameters character interaction propagating field erbium atoms gain loss term linear kerr nonlinearity inhomogeneous parameter affect interaction range second order rogue waves elsevier ltd rights reserved
several years increasing interest use unmanned aerial vehicles acquiring image data low altitude considering cost effectiveness flight time uavs conventional airplanes use former advantageous generating large scale accurate ortophotos development uav imagery update large scale basic maps maps cartographic products used registration economic strategic planning basis maps cartographic maps produced example maps used building planning article presents assessesment usefulness orthophotos based uav imagery upgrade basic map research compact non metric camera mounted fixed wing powered electric motor used tested area covered flat agricultural woodland terrains processing analysis orthorectification carried inpho uasmaster programme due effect uav instability low altitude imagery use non metric digital cameras low accuracy gps ins sensors geometry images visibly lower compared conventional digital aerial photos large values phi kappa angles therefore typically low altitude images require large along across track direction overlap usually result research orthoimages obtained resolution meters horizontal accuracy digitized basic maps used reference data accuracy orthoimages basic maps estimated based study available reference sources result found geometric accuracy interpretative advantages final orthoimages allow updating basic maps estimated update basic maps based uav imagery reduces processing time approx
overactive bladder oab common condition experienced around million people world population associated significant impact patients quality life first line treatments oab conservative treatment anti muscarinic medication refractory oab patients treatment options available surgical therapy electrical stimulation botulinum toxin injection among percutaneous tibial nerve stimulation ptns minimally invasive option aims stimulate sacral nerve plexus group nerve responsible regulation bladder function approval food drug administration fda ptns revealed considerable promise oab management review several non comparative comparative studies comparing ptns sham procedure anti muscarinic therapy multimodal therapy combining ptns anti muscarinic supportive data consideration
visibly transparent solar harvesting surfaces exciting new approach harvesting solar energy around buildings mobile electronics improve efficiency autonomy without impacting appearance recent demonstration ultraviolet near infrared nir selective light harvesters enabled transparent luminescent solar concentrators lscs boast unparalleled scalability flexibility aesthetic quality affordability consequently question efficiency limits emerged new systems perspective theoretical efficiency limits concentrator systems reviewed practical considerations outlined approach limits nir selective harvesting single junction transparent lscs constrained thermodynamically increases fully transparent multipanel devices light trapping deriving limits key material engineering challenges identified fully optimize transparent solar concentrators push towards commercial reality
earlier days aircrafts used mechanical gyroscopes susceptible shock mechanical damage low accuracy developments fibre optics led optics based gyroscopes today conventional aircraft uses sufficient gyroscopes perform action attitude control gyro compassing turn coordination systems auto pilots error gyroscope causes miscalculation position alignment aircraft commercial aircraft higher altitudes susceptible variations temperature case fibre optic gyroscopes fog results fluctuation laser power output turn disturbs output information proposed temperature control closed loop fibre optic gyroscope using thermo electric cooler tec stabilizing output power super luminescent diode sld control loop pid controller filter tec thermistor proposed part temperature control loop maintain tec surface temperature within specified temperature range simulated performance step input along finite disturbances applied temperature control loop along effect sld output power effect gyroscope output evaluated elsevier gmbh rights reserved
people use least two strategies solve challenge understanding another person mind inferring person perspective reading behavior theorization getting person perspective experiencing situation simulation five experiments reported demonstrate strong tendency people underestimate value simulation predictors estimated stranger emotional reactions toward pictures could either infer stranger perspective reading facial expressions simulate stranger perspective watching pictures viewed predictors substantially accurate got perspective simulation overestimated accuracy achieved inferring perspective predictors miscalibrated confidence stemmed overestimating information revealed facial expressions underestimating similarity people reactions given situation people seem underappreciate useful strategy understanding minds others even gain firsthand experience strategies
selective attention toward emotional cues emotion recognition facial expressions important aspects social cognition stress modulates social cognition cortisol acts glucocorticoid mineralocorticoid receptors brain examined role activation attentional bias toward emotional cues emotion recognition included healthy young women healthy young men mean age either received agonist fludrocortisone placebo dot probe paradigm used test attentional biases toward emotional cues happy sad faces moreover used facial emotion recognition task investigate ability recognize emotional valence anger sadness facial expression four graded categories emotional intensity emotional dot probe task found main effect treatment treatment valence interaction post hoc analyses revealed attentional bias away sad faces placebo intake shift selective attention toward sad faces compared placebo found attentional bias toward happy faces fludrocortisone placebo intake facial emotion recognition task main effect treatment stimulation seems important modulating quick automatic emotional processing shift selective attention toward negative emotional cues results confirm extend previous findings function however find effect stimulation emotion recognition
network science draws number fields examine complex systems using nodes represent individuals connections represent relationships individuals form network approach used several areas psychology illustrate influence structure network processing system present study concept keyplayers network borgatti examined domain psycholinguistics keyplayers nodes network removed result network fracturing several smaller components set nodes found network phonological word forms another set foil words comparable keywords number lexical network characteristics three conventional psycholinguistic tasks keywords responded quickly accurately foils similar trend observed analysis keywords foils another set foils english lexicon project results open avenues exploration keywords various areas language processing demonstrate utility network science approach psycholinguistics psychology generally elsevier inc rights reserved
paper overviews origin motivation unconventional molecular computing specially emphasizing advantages biomolecular systems designing highly sophisticated logic circuits technological solutions based flow design enzyme based logic gates discussed illustrated examples integration enzyme based logic gates concatenated assemblies signal responsive materials electronic interfaces suggested platform biomedical sensors actuators digitally responding yes format various combinations biomolecular signals particularly represented biomarkers important biomedical applications complexity designed enzyme based logic systems allowed logically reversible computing thus step forward development biomolecular computing devices features reversible biocomputing systems discussed particularly emphasizing logic reversibility physical reversibility perspectives novel advances discussed conclusion section giving futuristic vision possible applications biomolecular computing systems various biomedical specifically theranostic applications graphics fluidic enzyme based logic systems biosensor applications
aims objectives explore describe young adults years age experienced growing parent multiple sclerosis experiences continue influence daily lives background chronic parental illness occurring families worldwide little known children experience growing parent multiple sclerosis childhood young adulthood design chose qualitative design using phenomenological approach based giorgi methods exploratory open ended interviews young adults conducted results essence phenomenon parent multiple sclerosis synthesized striving balance caring restraint two themes caring restraint eight subthemes participants experiences caring parents multiple sclerosis continued influencing close relationships tended assume responsibility concealing feelings desires participants showed restraint among parents without multiple sclerosis friends partners conclusion seems one greatest challenges parent multiple sclerosis achieving balance caring others asserting one desires relevance clinical practice healthcare professionals support family encouraging family members participate consultations assist parents providing information multiple sclerosis symptoms children parents might need assistance applying help domestic chores referrals support groups children family members
objective follow primary care provider hospital discharge associated reduced likelihood readmission however primary care providers frequently unaware patients hospitalizations event notification may effective tool reducing readmissions notifying primary care providers patients admitted discharged hospital materials methods examined effect event notification system day readmissions bronx new york bronx among highest readmission rates country particularly challenging setting improve care due low socioeconomic status county high rates poor health behaviors among residents study cohort included medicare fee service beneficiaries associated hospital admissions period january june linear regression models beneficiary level fixed effects used estimate impact event notifications readmissions comparing likelihood rehospitalization beneficiary event notifications active results unadjusted day readmission rate event notifications active compared alerts active regression estimates indicated active hospitalization alert services associated percentage point reduction likelihood readmission confidence interval conclusions alerting providers event notifications may effective tool improving quality efficiency care among high risk populations
currently use stem cell transplantation treatment osteoporosis popular research topic general promotion osteogenic differentiation stem cells goal researchers micrornas mirnas mirs critical regulatory factors osteogenic induction mir mir substantiated involved osteogenic process yet underlying mechanisms remain unclear present study investigated role mir mir osteogenic differentiation bone marrow derived mesenchymal stem cells bmscs aimed elucidate mechanism osteogenic differentiation using mtt assay pcr found mir expression upregulated mir expression downregulated osteogenic differentiation moreover shown results mineralization analysis western blot analysis overexpression mir enhanced osteogenic abilities overexpression mir inhibited abilities furthermore mir mir also affected expression runt related transcription factor runx extracellular signal regulated kinase erk pathway western blot analysis based results conclude mir mir play key roles regulating differentiation bmscs
paper presents new energy management control strategy hybrid electric vehicle using dynamic programming preview driving cycle information dynamic programming promising solution energy management problem hybrid electric vehicle yet global optimality achieved preview driving cycle information due non causal property recent driving cycle prediction algorithms facilitate use preview driving cycle information rule based energy management strategy hybrid electric vehicle using dynamic programming optimization presented study assumption preview driving cycle information already given strategy composed dynamic programming calculation rule based control strategy using calculation dynamic programming analyzes optimal control battery state charge trajectory accordance vehicle travel distance given predicted driving cycle information proposed rule based strategy distributes vehicle demand power engine electric motor follow target battery state charge trajectory acquired dynamic programming validate control strategy simulation conducted various standard driving cycles energy management strategy shows improved fuel economy performance diverse driving cycles
branch bound well known generic method computing optimal solution single objective optimization problem based idea divide conquer consists implicit enumeration principle viewed tree search although branch bound first suggested land doig first complete algorithm introduced multi objective branch bound identified proposed kiziltan yucaoglu rather multi objective branch bound algorithms proposed situation surprising contributions extensions components branch bound multi objective optimization recent example concept bound sets extends classic notion bounds mentioned villarreal karwan developed first time ehrgott gandibleux fully defined paper describes state art multi objective branch bound reviews concepts components published algorithms mainly focuses contributions belonging class optimization problems received attention context linear optimization problems zero one variables mixed continuous variables papers aiming compute complete set efficient solutions discussed elsevier rights reserved
objectives longitudinally evaluate association post icu muscle weakness associated trajectories weakness time year survival design longitudinal prospective cohort study years follow setting thirteen icus four hospitals baltimore patients one hundred fifty six acute respiratory distress syndrome survivors interventions none measurements main results strength evaluated standardized manual muscle testing using medical research council sum score range higher better post icu weakness defined sum score less muscle strength assessed hospital discharge months acute respiratory distress syndrome discharge patients muscle weakness every one point increase sum score discharge associated improved survival hazard ratio similar findings longitudinally weakness discharge associated worse year survival association attenuated evaluated longitudinally follow persisting resolving trajectories muscle weakness occurring patients follow associated worse survival respectively compared trajectory maintaining muscle weakness conclusions hospital discharge greater one third acute respiratory distress syndrome survivors muscle weakness greater strength discharge throughout follow associated improved year survival patients post icu weakness persisting resolving trajectories commonly experienced associated worse survival follow
despite high rates occurring tobacco use anxiety symptoms disorders among persons hiv evidence based interventions individuals yet available present study sought evaluate integrated treatment model addressing smoking cessation anxiety sypmtoms among hiv positive smokers treatment week intervention integrating standard smoking cessation protocol cognitive behavioral therapy cbt nicotine replacement therapy cbt anxiety inclusion criteria years age cigarettes day state trait anxiety inventory stai score moderate motivation point likert scale quit smoking primary outcomes included scores anxiety sensitivity index asi cigarettes smoked per day self reported abstinence biochemically verified carbon monoxide breath analysis three male participants mean age completed month follow baseline participants reported smoking average cigarettes per day two participants quit smoking maintained abstinence month follow demonstrated reduction asi scores participant continued smoke reduced rate participants response cognitive behavioral strategies creating balanced thoughts interoceptive exposures discussed clinical lessons learned include use flexible approach cognitive restructuring use imaginal vivo exposures session better prepare patients homework practice flexibility delivering treatment individual group format clinical presentation provides preliminary support feasibility initial effectiveness integrated treatment reduce anxiety symptoms aid smoking cessation anxious hiv positive smokers
paper presents experimental results streamlined twin box girder span suspension bridge order investigate reynolds number sensitivity aerodynamic force pressure coefficients high speed wind tunnel testing carried scale sectional model aeronautical wind tunnel drag lift coefficients revealed significant decreases critical reynolds number range ordinary wind tunnel tests safety rail reduced reynolds number dependency aerodynamic force coefficients negative angles attack similarly boundary layer trip strip attached bottom surface girder reduced reynolds number dependency fixing flow separation pressure coefficients near gap twin boxes changed negative positive critical reynolds number represented smooth ventilation wind flow gap supercritical region imbalance drag lift forces acting box subcritical region gradually resolved boxes almost equally loaded forces supercritical region elsevier ltd rights reserved
comprehensive results cyclic plate loading diameter supported layers geocell presented plate load tests performed test pit measuring plane depth simulate half full traffic loadings fifteen loading unloading cycles applied loading plate amplitudes kpa optimum embedded depth first layer geocell beneath loading plate optimum vertical spacing geocell layers based plate settlement approximately times loading plate diameter results show installation geocell layers foundation bed increase resilient behavior addition reduction accumulated plastic total settlement pavement system efficiency geocell reinforcement decreased increasing number geocell layers applied stress levels number cycles applied loading results testing reveal ability multiple layers geocell reinforcement shakedown fully resilient behavior period plastic settlement except little reinforcement applied cyclic pressure large shakedown response observed accumulated plastic settlement prior steady state response obtained resilient settlements thereafter reduced use four layers geocell respectively decreases total residual plastic settlements increases resilient settlement compared unreinforced case inclusion geocell layers also reduces vertical stress transferred pavement distributing load wider area example end load cycle applied pressure kpa transferred pressure depth reduced reinforced bases one two three layers geocell respectively compared stress unreinforced bed
suppose piston nonzero mass encloses ideal gas vertical cylinder piston cylinder thermally insulated energy lost heat transfer surroundings piston set motion oscillates like block spring however motion damped gas density pressure immediately adjacent piston higher lower bulk values depending whether piston compressing expanding gas respectively automatically gives rise drag force linear velocity piston necessary add extra dissipative terms kinetic friction piston cylinder viscosity gas damp motion piston ideas thus helpful undergraduate students performing ruchardt experiment measure ratio heat capacities gas
flying capacitor converters fccs recently attracting considerable interest inherent natural voltage balancing property develop sampled data model single phase single leg three level fcc provides closed form expression system dynamic behavior switching cycle analysis model provides considerable insight fcc natural balancing property particular prove natural balancing property indeed holds whenever switching frequency sufficiently high also rigorously analyze dynamic properties capacitor time constant relate parameter values load carrier frequency duty ratio results shed light intricate relationship fcc parameters short long term dynamic behavior copyright john wiley sons ltd
explosion ever increasing geospatial data today met challenge maintaining spatial databases utilization traditional methods spatial data processing sheer volume complexity spatial databases makes ideal candidate use parallel distributed processing architectures lot enthusiasm toward using mapreduce paradigm distributed computing processing large volumes vector data spatial data indexed using traditional tree structures used dbms several libraries jsi java spatial index libspatialindex spatialite depend upon advanced data structures tree quad tree variants spatial indexing indexing mechanisms also natively incorporated frameworks spatial hadoop hadoop gis sato geospark additionally widely used open source rdbms mysql postgres sqlite incorporate spatial indexing using extensions add ons paper benchmark compare performance various spatial indexing mechanisms addition evaluating performance distributed frameworks planet sized datasets conclude highlighting characteristics spatial tools frameworks better selection implementation tree indexing big geo spatial processing system
article examine gender differences disposable incomes teenagers year period using large nationally representative survey data since gender pay gap working life rather persistent finland necessary see whether gap persists teenagers incomes well although teenagers receive much income work adapt structures society teenage years learn gender roles consumption education working life results reveal gender pay gap rather persistent finland particularly among year old teenagers among year olds gender difference income narrowed interactions gender socio economic indicators father education family place residence persistent gender pay gap explained solely wage differences age group full time work teenagers nowadays rare finland work much even part time although rather obvious boys get higher incomes girls external work allocation money parents seems unequal
differential scanning calorimetry dsc employed examine thermal behavior brain tissues affected drug induced neurodegenerative disorder animal mouse model scopolamine induced dementia used dsc measurements performed supernatants brain tissue homogenates revealed large differences heat capacity profiles healthy animals animals scopolamine induced dementia heat capacity profiles supernatants healthy animals displayed well expressed exothermic transitions peaking range degrees thus preceding temperature endothermic denaturational transitions exothermic transitions found samples animals centrifugation sediments brain homogenates liver homogenates blood plasma remarkably low temperature exotherms completely abolished scopolamine treatment exothermic events may possibly reflect process aggregation specific protein fractions brain supernatants reported findings may important elucidation molecular mechanisms cognitive impairment elsevier rights reserved
article presents hybrid pso levy flight algorithm lfpso optimization pid controllers employed automatic generation control agc nonlinear power system superiority proposed lfpso approach demonstrated comparing recently published lozi map based chaotic optimization algorithm lcoa particle swarm optimization solve load frequency control lfc problem found proposed lfpso method robust dynamic behavior terms settling times overshoots undershoots varying system parameters loading conditions nominal values well size locations disturbance secondly three area thermal power system considered nonlinear generation rate constraints grc outperforms results bacteria foraging algorithm based integral controller well hybrid differential evolution particle swarm optimization based fuzzy pid controller similar power system finally proficiency proposed controller also verified random load patterns
onychomycosis fungal infection fingernails toenails caused dermatophytes yeasts non dermatophyte moulds epidemiology onychomycosis serbia yet fully established epidemiological study aimed evaluating epidemiology onychomycosis sample serbian patients risk onychomycosis determine fungal aetiological agents identify possible risk factors study population included patients six centres serbia suspected onychomycosis demographic data data comorbidities lifestyle clinical aspects onychomycosis trauma excessive perspiration personal family history previous onychomycosis studied laboratory confirmation diagnosis done direct microscopy fungal culture pcr diagnosis onychomycosis confirmed patients tested positive least one laboratory test direct microscopy fungal culture pcr trichophyton rubrum predominant toenails fingernails independent risk factors onychomycosis old age family history previous onychomycosis tinea pedis excessive perspiration higher degree hyperkeratosis first epidemiological study onychomycosis serbia
purpose purpose paper examine specific stressors demands perceived control received support stress management strategies crisis managers executives supervisors organizations involved disaster response context large scale missions design methodology approach totally semi structured interviews crisis managers conducted five european countries analyzed qualitative text analysis method gabek findings sample reported high demands various sources stress including event specific stressors well group specific occupational stressors responsibility decision making justification failures dealing press media possibilities control perceived limited large scale missions organizational peer support played important role mitigating mission related stress effective stress management strategies reported crucial ensure successful crisis management need comprehensive stress management trainings emphasized originality value stressors coping strategies first responders emergency services personnel previously examined corresponding research regarding professional group crisis management leaders remains scarce therefore study makes important contribution examining influential stressors within work environment crisis managers identifying starting points requirements stress management trainings psychosocial support programs
research shown children learning disabilities less prone evince associative illusions memory result impairments ability engage semantic processing however unclear whether observation true scripted life events especially include emotional content across broad spectrum learning disabilities present study addressed issues assessing recognition memory script like information children nonverbal learning disability nld children dyslexia typically developing children participants viewed photographs common events family dinner embedded episode either negative neutral consequence unseen action children memory tested yes recognition task included old new photographs results showed three groups performed similarly recognizing target photographs exhibited differences memory errors compared groups children nld likely falsely recognize photographs depicted unseen cause emotional seen event associated remember responses errors children dyslexia equally likely talsely recognize unseen causes seen photographs photographs generally consistent script whereas participant groups likely falsely recognize unseen causes rather script consistent distractors results interpreted terms mechanisms underlying false memories formation different clinical populations children elsevier ltd rights reserved
study introduces novel unified interface design uid concept develop factory automation production manufacturing systems lcd industry response recent needs smart factory production integration manufacturing information manufacturing sector automation technology systems play increasingly important role integrating production applications implementation automation transportation system ats also started single systems material systems evolved incorporate multiple applications roles material information intelligent management since upgrading manufacturing technology developed uid innovative models integrate manufacturing engineering concepts effectively integrated system material information flow therefore purpose study evaluate innovative concepts used implement ats uid concepts integrated production engineering effectively combine system material information flow actual process allows identify critical elements may emulated used reference similar companies industries interested developing uid reducing risks failure
building oscillator based computing systems emerging nano device technologies become promising solution unconventional computing tasks like computer vision pattern recognition however simulation analysis computing systems time compute intensive due nonlin earity new devices complex behavior coupled oscillators order speed simulation coupled oscillator systems propose simplified phasemodel perform phase frequency synchroniza tion prediction based synthesis earlier models model predict frequency locking behavior several orders magnitude speedup compared direct evaluation enabling effective efficient simulation large numbers oscillators required practical computing systems demonstrate oscillator based computing paradigm three applications pattern matching convolution image segmentation simulation models respectively sped factors tests
background patients existence psychiatric disorders substance use increased risk premature death attributable higher prevalence physical comorbidities lifestyle related substance use furthermore experience low quality life qol studies addressing lifestyle interventions patients warranted aims investigate physical health qol patients existence psychiatric disorders substance use analyse changes health substance use qol month health promotion programme aims investigate associations qol number interventions qol patient characteristics qol length participation intervention methods naturalistic cohort study non selected patients engaged health promoting interventions added contemporary treatments qol clinical variables measured beginning continuously programme means whoqol bref questionnaire results enrolment patients intake cannabis alcohol high follow patients consumed significantly fewer caffeinated beverages fast food meals slept significantly less average dose antipsychotic medication increased significantly qol low enrolment improved significantly overall psychological environmental domains follow difference total qol positively associated number interventions attended conclusion programme shows promise addressing health promotion patients easily integrated contemporary treatments
background thoracic aortic disease high mortality sought establish contribution unwarranted variation care regional differences outcomes observed patients thoracic aortic disease england methods results data hospital episode statistics hes national adult cardiac surgery audit nacsa extracted parallel systematic review meta analysis december structure process questionnaire english cardiac surgery units also accomplished treatment mortality rates investigated total adult patients hes study nacsa study total studies systematic review obtained treatment rates thoracic aortic disease within months index admission ranged english counties risk adjusted month mortality untreated patients ranged regional variation persisted adjustment disease patient factors regional cardiac units higher case volumes treated complex patients significantly lower risk adjusted mortality relative low volume units results systematic review indicated delivery care multidisciplinary teams high volume units resulted better outcomes observational analyses online survey indicated services configured units england conclusions changes organization services address unwarranted variation provision care patients thoracic aortic disease england may result equitable access treatment improved outcomes
magnesium suggested anti inflammatory properties short term mostly vitro studies examine effect dietary magnesium modifications arthritis severity joint damage rats placed one three diet regimens induction autoimmune pristane induced arthritis pia low magnesium diet normal diet magnesium supplemented diet diets switched normal diet days induction pia typical time disease onset arthritis severity scored days joints examined histology quantitative pcr proinflammatory genes rats low magnesium diet significantly reproducibly protected lower median arthritis severity score preservation normal joint histology without erosive changes rats normal magnesium supplemented diets protected developed equally severe erosive disease dietary modifications disease onset day postinduction protective effect short term low magnesium diet persisted suggesting lasting effect critical pathogenic pathway rats low magnesium diet significant reduction synovial tissue expression rora rorc genes required development cells study revealed novel role dietary magnesium regulation autoimmune arthritis opens new possibilities treatment autoimmune diseases rheumatoid arthritis psoriatic arthritis short courses dietary drug induced modulations magnesium levels
important establish forecasting model network security situation network security situation observed directly measured observable data paper network security situation considered hidden behavior order predict hidden behavior methods proposed however methods use hybrid information includes qualitative knowledge quantitative data forecasting model network security situation proposed basis hidden belief rule base brb model inputs multidimensional initial parameters hidden brb model given experts may subjective inaccurate order train parameters revised covariance matrix adaption evolution strategy cma algorithm developed adding modified operator revised cma algorithm optimize parameters hidden brb model effectively case study shows compared methods proposed hidden brb model revised cma algorithm predict network security situation effectively improve forecasting precision making full use qualitative knowledge elsevier rights reserved
non celiac gluten sensitivity ncgs term used describe individuals complaining intestinal extra intestinal symptoms related gluten ingestion rapidly improving withdrawal celiac disease wheat allergy properly ruled prevalence condition remains unknown lot questions possible pathogenetic mechanisms still unclarified believed ncgs represents heterogeneous condition different subgroups potentially characterized different pathogenesis clinical history clinical course moreover possible overlap irritable bowel syndrome ibs functional diseases could complicate patient selection clinical studies slowing understanding disorder last least lack validated biomarkers remains significant limitation research studies ncgs iience need strict diagnostic criteria ncgs
biocrusts critical components desert ecosystems significantly modifying surfaces occupy mixture biological components soil particles form crust conjunction moisture determines biocrusts spectral signatures proximal remote sensing complemeritary spectral regions namely reflective region thermal region used study biocrusts non destructive manner laboratory field space objectives review paper present spectral characteristics biocrusts across optical domain discuss significant developments application proximal remote sensing biocrust studies last years motivation using proximal remote sensing biocrust studies disttissed next application reflectance spectroscopy study biocrusts presented followed review emergence high spectral resolution thermal remote sensing facilitates application thermal spectroscopy biocrust studies four specific topics forefront proximal remote sensing biocrusts discussed use remote sensing determining role biocrusts global biogeochemical cycles monitoring inceptive establishment biocrusts identifying characterizing biocrusts using longwave infrared spectroscopy diurnal emissivity dynamics biocrusts sand dune environment paper concludes identifying innovative technologies low altitude high resolution imagery increasingly used remote sensing science expected used future biocrusts studies elsevier rights reserved
commercially available functional near infrared spectroscopy fnirs systems employ optical fibers measurement optode transmission cable optical signals material inflexibility presents problems stable optode fixation head surface adequate cable lining main system practice mechanical fluctuations optical fibers fnirs measurement often lead motion artifacts signals fiber less fnirs systems available equipped light sources detectors directly adhere scalp surface however shapes detection sensitivities suitable usage hair covered head based commercial fiber less fnirs system oeg spectratech inc japan developed new source detector unit designed leds enhanced illumination avalanche photodiodes instead photodiodes new holder system electrical circuits system modified design simultaneous implementation multi distance fnirs measurement hemodynamic modality separation conventional fnirs data bilateral parietal area single sided motor tasks significant functional signals observed position contralateral side movement first report describing fiber less fnirs system detect functional signals hair covered head believe fiber less system improve utility fnirs particularly less restraining conditions
general similarity solution water entry problems wedge inner angle fixed sides expansion obtained flow detachment speed expansion free parameter known solutions wedge fixed length initial stage water entry without flow detachment final stage corresponding helmholtz flow obtained two special cases finite zero expansion speeds respectively expanding horizontal plate impacting flat free surface considered special case general solution wedge inner angle equal initial impulse solution plate fixed length obtained special case present formulation general solution obtained form integral equations using integral hodograph method results presented terms free surface shapes streamlines pressure distributions
extensive green roof systems expected synergetic effect mitigating urban runoff decreasing temperature supplying water building mitigation runoff rainwater retention requires effective design green roof catchment study identified improve building runoff mitigation quantitative analysis extensive green roof system quantitative analysis green roof runoff characteristics indicated extensive green roof high water retaining capacity response rainfall less rainfall intensity increased water retaining capacity decreased catchment efficiency extensive green roof ranged indicating reduced runoff comparing efficiency concrete roof therefore extensive green roofs effective storm water best management practice proposed parameters applied algorithm rainwater harvesting tank design elsevier ltd rights reserved
introduce new parallel pattern derived specific application domain show turns application beyond domain origin pool evolution pattern models parallel evolution population subject mutations evolving way given fitness function optimized pattern demonstrated suitable capturing modeling parallel patterns underpinning various evolutionary algorithms well parallel patterns typical symbolic computation paper introduce pattern discuss implementation modern multi many core architectures finally present experimental results obtained fastflow erlang implementations assess feasibility scalability
aim effective hybrid electric vehicle hev energy management strategy reduce fuel consumption undesired pollutant emission levels maintaining drivability battery state charge soc high fidelity laboratory test platform enables verification validation testing strategy developed shortest possible time essential demanded quality performance levels paper presents hardware loop simulator developed evaluation hev energy management algorithms emas hardware loop hil simulation model front rear wheel electric motor driven hybrid electric commercial van internal combustion engine powering front wheels presented ema used platform also introduced finally hil simulation results compared road test results demonstrate effectiveness proposed approach
ambient intelligence technologies making daily life increasingly virtual boundary real world virtual world gradually disappearing computer games often played internet allows people enjoy games others even location paper analyzes trading card game tcg two versions one version played paper based cards whereas played computer computer based tcg supports remote play number enhancements providing special fictional effects virtual cards two different versions useful analyze influence virtuality making future social interaction playful first investigate potential pitfalls introduce virtuality tcg scenario based analysis adopts player personality exploit potential difficulties investigating insights influence virtuality tcg analyze experiments augmented trading card game real opponent player replaced fictional player findings analyses show feeling realness essential make incorporated virtuality successful recently games concepts adopted order augment real world essential investigate influence virtuality introduced games future social interaction incorporate virtuality based variety game like features make interaction playful therefore insights described paper useful help design future playful social interaction
purpose plasma kallikrein serine protease circulating component inflammation exerts clinically significant effects vasogenic edema study examines role plasma kallikrein vegf induced retinal edema methods intravitreal injections vegf saline vehicle performed plasma prekallikrein deficient klkb wild type mice rats mice receiving selective plasma kallikrein inhibitor retinal vascular permeability rvp retinal thickness measured evans blue permeation optical coherence tomography respectively retinal kallikrein kinin system examined western blotting immunohistochemistry retinal neovascularization investigated klkb mice subjected oxygen induced retinopathy results vascular endothelial growth factor induced rvp retinal thickening reduced klkb mice respectively compared vegf responses mice plasma kallikrein also contributes tnf alpha induced retinal thickening reduced klkb mice systemic administration reduced vegf induced retinal thickening mice rats compared vehicle treated controls intravitreal injection vegf mice increased plasma prekallikrein retina diffusely distributed throughout inner outer retinal layers avascular neovascular areas induced oxygen induced retinopathy similar klkb mice conclusions vascular endothelial growth factor increases extravasation plasma kallikrein retina plasma kallikrein required full effects vegf rvp retinal thickening rodents systemic plasma kallikrein inhibition may provide therapeutic opportunity treat vegf induced retina edema
paper analyses represented images men women casino ads macau examines impact gender power casino industry discusses social cultural construction masculinity femininity culturally diverse context social semiotic analysis range casino brochures leaflets presented analysis reveals stereotypical portrayals gender roles persist macau casino ads privilege male tourist gaze reproduce gender power relations within hetero patriarchal system despite trend women involvement public gambling casino gambling continues upheld masculine activity macau study argues casino space constructed two aspects simultaneous masculinisation gambling feminisation interactive service work reflect respectively traditional expectations gambling culture demands modern service intensive casino business
study examined patterns cerebellar volumetric gray matter loss across adult lifespan large cross sectional sample four hundred seventy nine healthy participants age range years drawn brain resource international database provided weighted mri scans spatially unbiased infratentorial template suit toolbox spm used normalisation cerebellum structures global volumetric voxel based morphometry analyses performed evaluate age associated trends gender specific age patterns global cerebellar shows cross sectional reduction advancing age per decade approximately half rate seen whole brain male cerebellum larger lower percentage however controlling total brain volume gender difference detected analysis age related changes volume revealed large bilateral clusters involving vermis cerebellar crus regional loss occurred nearly twice average cerebellar rate gender specific patterns detected data confirm regionally specific loss occurs cerebellum age form solid base investigation find functional correlates global focal loss
recent increase satellite based navigation applications ionospheric total electron content tec band scintillation measurements gained significant importance paper present temporal spatial variations tec derived simultaneous continuous measurements made first time using indian gps network receivers located equator northern crest equatorial ionization anomaly eia region beyond covering geomagnetic latitude range degrees degrees using month period data low sunspot activity lssa years march june diurnal variation tec eia region shows steep increase reaches maximum value equator peak broad occurs around short lived day minimum occurs stations equator eia crest region beyond crest region day maximum values decrease increase latitude day minimum tec flat nighttime hours feature similar observed mid latitudes diurnal variation tec show minimum maximum variation tec units respectively equator tec units eia crest region correspond range delay variations equator crest region gpsl frequency ghz day day variability also significant stations particularly daytime hours maximum variations eia crest regions similar variations also noticed corresponding equatorial electrojet eej strength known one major contributors observed day day variability tec seasonal variation tec maximizes equinox months followed winter minimum summer months feature similar observed integrated equatorial electrojet ieej strength corresponding seasons indian sector eia crest found occur latitude zone degrees degrees geographic latitudes degrees degrees geomagnetic latitudes eia also maximizes equinoxes followed winter significant summer months lssa period studies also reveal location eia crest peak value tec linearly related ieej strength increase increase ieej
structural monitoring systems objective quantitative based management tool developed assist structure owners diagnostic prognostic decision making processes sensing technologies mature deployment permanent sensing arrays structures becoming popular resulting increasing volumes sensing data comprehensive data management systems needed host curate heterogeneous data sets associated structural asset management including structural information design inspection information massive amounts sensing data importantly data management system must also provide functional secure means allowing software clients perform analytics data contained system paper scalable secure cyberinfrastructure platform termed senstore introduced management automated analysis sensing data senstore includes hybrid database architecture maximizes query speed storing structural metadata relational database sensor data hierarchical data format repository multimedia files inspector photos flat file system design senstore presented followed description application manage process data associated long term wireless monitoring system installed telegraph road bridge monroe michigan illustrate effectiveness senstore tracking performance monitored bridges study automates process extracting modal data telegraph road bridge sensor data stored senstore using modal parameters update finite element model integral bridge owner decision making processes american society civil engineers
context bladder management spina bifida patients relies clean intermittent catheterization oral antimuscarinics significant failure rate efficacy intradetrusor injections botulinum toxin confirmed patients spinal cord injury multiple sclerosis patients myelomeningocele objective conduct systematic review current evidence regarding efficacy intra detrusor injections botulinum toxin btx spina bifida patients neurogenic detrusor overactivity ndo refractory antimuscarinics methods research conducted medline embase using keywords spina bifida myelomeningocele dysraphism toxin search strategy studies selection performed using picos method according prisma statement result twelve published series included patients patients years old randomized study comparing btx versus placebo studies control group studies reported clinical urodynamic improvement resolution incontinence patients decrease maximum detrusor pressure increase maximum cystometric capacity improvement bladder compliance two studies suggested lower efficacy patients low compliance bladder compared isolated detrusor overactivity conclusion intradetrusor injections btx could effective children spina bifida assumption supported high level evidence studies data available adult patients neurourol urodynam wiley periodicals inc
vehicular network recently used achieve high efficient flexible traffic scheduling intersection roads smart transportation systems different existing works traffic signal used schedule waiting vehicles lane propose divide vehicles lane small groups schedule vehicle groups via wireless communication rather traffic lights direct scheduling vehicles reduce waiting time improve fairness especially traffic volume different lanes imbalanced key challenge design lies determining appropriate size groups respect real time traffic conditions cope issue propose neuro fuzzy network based grouping mechanism network trained using reinforcement learning technique also vehicle groups scheduled via neuro fuzzy network simulations using conducted evaluate performance algorithm compare similar works results show algorithm reduce waiting time time improve fairness various cases advantage traffic light algorithms
patients anorexia nervosa experience increased sensitivity risk social rejection aims study assess interpretation ambiguous social scenarios depicting risk rejection examine relationship interpretation biases clinical symptoms thirty five women anorexia nervosa healthy eaters completed clinical questionnaires alongside sentence completion task task required participants generate completions ambiguous social scenarios endorse best completion responses rated negative neutral positive patients endorsed negative interpretations fewer neutral positive interpretations compared healthy eaters frequency endorsed negative interpretations correlated depression anxiety fear weight gain body disturbance negative interpretation bias towards social stimuli present women anorexia nervosa correlates clinical symptoms interventions aimed reducing bias could improve illness prognosis copyright john wiley sons ltd eating disorders association
even though contraceptive coverage expands patient protection affordable care act reducing disparities contraceptive access provision requires providers assess patient reproductive life plans health systems work minimize institutional socioeconomic barriers article challenges providing equal access contraceptive care well recommendations encouraging use effective contraception among reproductive age women reviewed
background recent global data show increasing prevalence psoriasis psoriatic arthritis western countries objective current study analyzed trend prevalence rates psoriasis psoriatic arthritis taiwan examined biologic prescription patterns different specialties methods data accessed national payer national health insurance research database taiwan study protocol approved joint institutional review board established medical research ethics foundation results prevalence psoriasis psoriatic arthritis increased per population per population respectively prevalence psoriatic arthritis among patients psoriatic disease increased dermatologists main caregivers patients psoriasis psoriatic arthritis however data suggest decreasing trend proportion dermatologists psoriasis patients corresponding decrease dermatologists psoriatic arthritis patients periods respectively patients psoriasis received biologics dermatologists rheumatologists psoriatic arthritis patients received biologics rheumatologists dermatologists proportion biologics use among patients psoriasis among patients psoriatic arthritis seen dermatologists rheumatologists respectively conclusion prevalence psoriasis psoriatic arthritis increasing taiwan use biologics patients psoriatic arthritis comparable reported previous studies united states europe however use biologics remained low patients psoriasis taiwan japanese scciety investigative dermatology published elsevier ireland ltd rights reserved
background studies carried examine whether onset progression opioid substance use disorder sud differed first used opioids get high compared received prescription doctor relieve pain non groups respectively methods subset patients ongoing larger study patients entering one drug treatment programs opioid use disorder across country agreed give anonymity participate structured open ended online interviews examining drug abuse patterns results exception non group began opioid abuse younger age group quickly evolved initial exposure regular opioid abuse relatively differences characteristics patterns trajectories opioid abuse vast majority patients groups serious antecedent psychiatric disorders indicated used opioids self medicate psychological problems stated opioids provided means escape stresses everyday life sud progressed many individuals positive attributes opioids waned avoidance withdrawal became overriding concern often serving impetus treatment conclusions results suggest self treatment morbid psychiatric disturbances powerful motivating force initiate sustain abuse opioids initial source drugs prescription experimentation largely irrelevant progression sud authors published elsevier ireland ltd
partitioning operating systems poss widely applied safety critical domains aerospace automotive order improve safety certification process poss arinc standard developed complied mainstream poss rigorous formalization arinc reveal hidden errors standard provide necessary foundation formal verification poss arinc applications purpose reusability efficiency novel methodology integrating ontology refinement proposed formally specify analyze poss paper ontology poss developed intermediate model informal descriptions arinc formal specification event semiautomatic translation ontology arinc event implemented leads complete event specification arinc compliant poss formal analysis six hidden errors arinc discovered fixed event specification also validate existence errors two open source poss xtratum pok introducing ontology degree automatic verification event specification reaches higher level
pressurized heavy water reactor phwr highly complex unstable system designing safe reliable robust controller good performance large complex system important control engineering problem work decentralized fuzzy logic controller dflc input output membership functions designed order multi input multi output mimo type phwr order obtain high performance controller needs tuned optimally however challenging task optimally tune dflc large membership functions moreover phwr coupled system imposes additional limitation tuning controller since output one phwr zone affects outputs zones work application nelder mead algorithm nma presented auto tuning dflc nma performance depends upon objective function initial points given nma start tuning process novel method selecting optimal objective function initial points nma also proposed since selection another complicated process although several objective functions proposed researchers use nma work focuses five common indices iae ise itae itse iste objective functions simple system independent finally optimally tuned high performance dflc applied phwr evaluated simulating different scenarios simulation results show controller efficient fast robust ensures safety reliability phwr elsevier ltd rights reserved
measurement based method evaluate efficiency antennas used microwave tissue imaging proposed method versatile principle applicable antennas operating free space well two identical antennas employed one transmitting one receiving signal flow graph sfg developed two port network formed antennas medium medium electrical properties mimic tissue vary according application several measurements performed one antennas loaded known loads system equations constructed acquired data solution system produces efficiency antenna addition unknown parameters sfg efficiencies two antennas estimated measured simulated data verified comparisons
emotion regulation research common distinguish adaptive maladaptive emotion regulation strategies however little known interactional impact compensational interfering effects adolescents adjustment collected longitudinal multiple informant questionnaire data adolescents parents examine prevalence adolescents anger regulation profiles using latent profile analysis identified five anger regulation profilesan adaptive maladaptive low medium undefined profile first three profiles could replicated year later could one additional multiple another undefined profile findings supported assumption adaptive strategies compensate negative impact maladaptive strategies yielding negative psychosocial consequences particularly maladaptive profiles moreover different profiles divergently related adolescents internalizing externalizing problems concurrently time results highlight importance considering adaptive maladaptive anger regulation strategies prevention psychotherapy
objective product gene activator amino acid oxidase suggested play role pathogenesis schizophrenia increased protein levels may associated disturbed glutamatergic transmission increased reactive oxygen species one pilot study lin investigated potential role serum protein levels biomarker schizophrenia study aimed compare serum protein levels patients schizophrenia healthy controls retest results previous pilot study materials methods total patients diagnosis schizophrenia according inclusion exclusion criteria age sex matched healthy controls included study groups compared regarding serum protein levels results mean serum protein values schizophrenia group healthy control group mean serum protein level significantly increased schizophrenia group compared healthy control group receiver operating characteristics analysis performed compare schizophrenia healthy control groups determined cut value sensitivity specificity conclusion suggest serum protein levels may represent candidate biomarker schizophrenia confirmed results previous preliminary study additional studies larger sample sizes inclusion first episode schizophrenia patients required clarify reliability validity serum protein levels biomarker schizophrenia
field programmable gate arrays fpgas established one preferred digital implementation platforms plethora current industrial applications extensions improvements still continuously included devices paper reviews recent advancements fpga technology emphasizing novel features may significantly contribute development efficient digital systems industrial applications special attention paid design paradigm shift caused availability increasingly powerful embedded soft processors transformed fpgas hardware accelerators powerful system chip soc platforms new analog resources floating point operators hard memory controllers also described great advantages provide designers software tools strongly influenced design paradigm shift requires fromthem much better support software developers focusing mainly issue recent advancements software resources intellectual property cores design tools also reviewed impact new fpga features industrial applications analyzed detail three main areas namely digital real time simulation advanced control techniques electronic instrumentation focus mechatronics robotics power systems design way digital systems currently designed areas comprehensively reviewed critical analysis could significantly benefit new fpga features presented
patient male final diagnosis chronic lymphocytic leukemia symptoms arthritis medication clinical procedure specialty oncology objective rare existance disease pathology background chronic lymphocytic leukemia cll common leukemia affecting older adults many patients suffer existing disease states provider must take comorbidities account determining treatment regimen widespread use monoclonal antibodies mabs drastically changed treatment landscape multiple diseases ranging leukemia autoimmune conditions rheumatoid arthritis case report present case patient progression cll rheumatoid symptoms rituximab therapy subsequently treated second generation anti antibody obinutuzumab obinutuzumab therapy associated simultaneous sustained remission disease states allowing discontinuation disease modifying anti rheumatic drugs dmards prolonged remission cll conclusions anti antibodies clear role treatment leukemia inflammatory conditions success obinutuzumab fully evaluated present case evidence strong role anti therapy multiple conditions unique opportunity control simultaneous disease states targeted inhibition shared common pathways
weight related issues including excess weight disordered eating body concerns often considered comprising distinct domains obesity eating disorders commentary argue concept weight bias important variable considering wellbeing across spectrum weight related issues make following six points support argument weight bias common adverse health consequences shaming individuals body weight motivate positive behaviour change iii internalized weight bias particularly problematic public health interventions carefully thought perpetuate weight bias weight bias manifestation social inequity action weight bias requires upstream population level approach achieve sustainable reductions weight bias population level substantive modifications collaborative efforts multiple settings must initiated provide several examples population level interventions reduce weight bias
paper presents research investigating application technology collaborative decision making distributed manufacturing engineering projects system frame work collaborative project management interaction identified agents presented discussed
need better access evidence based parenting interventions widely recognized families actually participate parenting programs public health approach includes delivery parenting information via internet could increase reach interventions dramatically however concerns web based information accessible families face greatest barriers accessing traditional face face parenting support therefore could benefit online approaches study used cross sectional survey australian parents year olds investigate parents use internet access parenting information extent information useful parents range socio economic backgrounds results indicate majority parents use parenting websites social media parenting information users parenting websites tended parents younger children younger age child also associated using social media younger parental age female working spending hours online parents rated range modalities useful receiving parenting information particularly seminars individually tailored programs self directed web based programs endorsed respondents higher risk parents likely likely endorse web based information sources lower risk parents almost equal access online parenting information among families different backgrounds conclude internet provides exciting opportunity delivering evidence based parenting support broad range parents including higher risk families
clay roofing tiles fired five different temperatures degrees subjected investigations textural characteristics frost resistance prediction closed container hydraulic pressure mechanisms proved dominant lower firing temperatures degrees whereas micro ice lens formation mechanism significant role higher temperatures degrees highest resistance noticed samples fired degrees frost action mechanisms balanced porous structure compensates local stresses developed freezing prediction frost action durability clay roofing tiles appearance first cracks prediction frost action mechanisms given statistical model showed high level agreement statistical model contains capillary pores ratio frozen unfrozen water significant parameters describing susceptibility closed container mechanism micro ice lens formation mechanism respectively doi asce american society civil engineers
date still big challenge investigate charge transfer behavior bulk surface solar energy conversion utilization herein bif biocl heterojunction prepared mild post synthesis method surface photovoltage spectra spv results show negative spv signal observed biocl suggesting photogenerated electrons mainly move surfaces accumulate surface negative positive signals observed bif biocl indicating photogenerated electrons holes move surfaces accumulate surface nearly spv signal observed bif demonstrating nearly electrons holes accumulate surface furthermore ultraviolet light irradiation lambda degradation rate times higher biocl bif degradation nitrophenol respectively hold charges transfer separation efficiency bif biocl significantly improved synergetic effect surface electric field bulk internal electric field interface electric field work could help intensively understand charge transfer behavior heterojunction photocatalyst elsevier rights reserved
whether like person often appraised glance however short presentation durations stimuli harder perceive according hedonic fluency theory holds higher fluency linked higher liking thus liked less given liking considerably influences person perception tested shorter longer presentation durations affect liking faces compared abstract patterns capture facets fluency processing assessed felt fluency liking certainty ratings following predictions fluency theory longer presentation durations led higher felt fluency certainty positively affected liking judgments abstract patterns faces felt fluency certainty also increased longer durations however longer durations faces liked less liking related felt fluency words contrast hedonic fluency theory faces attractive seen short amount time thus fluency inevitably lead positive evaluations rather depends stimulus category discuss findings terms special status faces regard human perception evaluation
authors present control principle multiphase interleaved converter used vastly reduce output current ripple converter control algorithm easily implemented using microcontroller without current loop phase converter works discontinuous conduction mode dcm close boundary conduction mode bcm converter control algorithm useful applications require precise current adjustment prototype converter built experimental results current ripple presented paper
human immunodeficiency virus hiv infection methamphetamine dependence associated neural injury preferentially involving frontostriatal circuits little known however commonly comorbid conditions impact behavioral presentations typically associated frontal systems dysfunction sample comprised hiv uninfected nondependent hiv uninfected dependent hiv infected nondependent hiv infected dependent subjects participants completed self report measures frontal systems behaviors including impulsivity disinhibition sensation seeking apathy also underwent comprehensive neurocognitive neuropsychiatric assessments allowed detailed characterization neurocognitive deficits comorbid premorbid conditions including lifetime mood substance use disorders attention deficit hyperactivity disorder antisocial personality disorder multivariable regression models adjusting potential confounds demographics comorbid premorbid conditions showed dependence independently associated increased impulsivity disinhibition sensation seeking apathy hiv infection greater apathy however see synergistic additive effects hiv frontal systems behaviors global neurocognitive impairment relatively independent frontal systems behaviors consistent view constructs may relatively separable biopsychosocial underpinnings future research explore whether neurocognitive impairment frontal systems behaviors may independently contribute everyday functioning outcomes relevant hiv elsevier ireland ltd rights reserved
psoriatic arthritis chronic inflammatory disease musculoskeletal system association skin psoriasis characterized variable clinical symptoms heterogeneous degrees disease suffering patients clinical manifestations essentially include alterations skin nails peripheral arthritis enthesitis dactylitis spinal involvement variability necessitates individualized therapy patients different therapy targets apart international guidelines therapy recommendations available germany treatment psoriatic arthritis reason article summarizes established points characteristics aspects considered therapy psoriatic arthritis germany taking various main forms disease consideration
tradition broadest sense total knowledge customs behaviors passed generation generation widely known cultural heritage knowledge based experience customs behaviors archived oral tradition knowledge passed rituals signs communication comprised codes transmission customs knowledge rituals signs symbols turkish folksongs realized repetition text along melody turkish folksongs characteristics musical archive possible achieve data areas folklore thanks archive text folksong dunur aga considered guide wedding customs rituals catalzeytin district kastamonu province study content dunur aga folksong analyzed text performance contribution cultural transmission function education content signs representations symbols evaluated although origins folksong unknown thought financial emotional difficulties marriage kastamonu catalzeytin need communication resulting difficulties giving sons marriage effective creation folksong
mental health professionals increasingly aware need competence treatment clients pornography related concerns however researchers recently sought explore efficacious treatments pornography related concerns explorations potential clinical judgment issues occurred due sensitive times uncomfortable nature client disclosures sexual concerns within therapy therapists required manage discomfort retaining fidelity treatment present paper explores clinician examples judgment errors may result feelings discomfort specifically client use pornography issues potential bias bias management techniques therapeutic implications discussed
urban storm water runoff carries particulate matter pollutants water bodies causing environmental problems removing suspended solids runoff geotextile filtration storm water control measure currently investigation could help lessen negative impacts storm water aquatic ecosystems study three geotextiles tested laboratory setup influent suspensions hydraulic loading rates total suspended solids tss concentration particle size distributions similar reported urban highway storm water runoff results indicated short priming period three geotextiles effectively remove suspended solids target concentration results also showed influent hydraulic loading rate tss concentration minimal effects total mass solids captured filter whereas particle size distribution affect total mass solids captured filters retention criteria choosing appropriate geotextile storm water treatment established recent literature evaluated using laboratory results geotextiles sand filters directly compared using results laboratory column testing sand filters performed study results indicate geotextile outlast sand filter terms total solids loading similar conditions
objective various sleep related symptoms occur parkinson disease occurrence health related quality life hrql comorbid sleep disorders comorbidities studied methods altogether randomly selected patients parkinson disease aged years participated questionnaire study structured questionnaire items based basic nordic sleep questionnaire questions demographics sleep disorders comorbidities included results response rate answered questions used analyses occurrence long sleep found subjects short sleep poor sleep sleep deprivation disrupted sleep difficulties fall asleep respectively poor self rated health poor quality life occurred participants logistic regression age gender differentially predicted long sleep sleep deprivation older age male positively associated long sleep negatively associated report sleep deprivation depression subjective negative stress fatigue occurred long sleep hand poor sleep excessive daytime sleepiness occurred short sleep sleep deprivation conclusions sleep difficulties frequent long sleeping patients depression stress fatigue
electricity production wind power constitute nearly electricity demand denmark paper look optimal expansion transmission network order integrate wind power system minimizing total fixed investment cost expected cost power generation allow active switching transmission elements reduce congestion effects caused kirchhoff voltage law results show actively switching transmission lines may yield better utilization transmission networks large scale wind power increase wind power penetration furthermore shown transmission switching likely affect optimal line capacity expansion plan
background collection routine clinical data setting research registries serve important role understanding real world care however relatively little known patient experience registries motivating survey patients enrolled two chronic disease registries methods conducted similar surveys two disease based registries based one academic medical center one group patients rheumatoid arthritis enrolled registry focused retention factors second group patients inflammatory bowel disease ibd recently enrolled considering enrollment examined factors would influence enrollment willingness answer frequent questionnaires give biospecimens surveys analyzed using descriptive statistics two cohorts compared using nonparametric chi square tests results received completed surveys ibd patients mean age subjects years ibd women respondents ibd two groups described similar factors top three motivations participation desire help others desire improve care disease ease volunteering preferred methods surveying included mail mail telephone favored age important correlate preference respondents preferred surveys either every months ibd every months ibd differed preference payment answering surveys answering payment necessary ibd felt similarly conclusions patients engaged clinical registries demonstrate high level commitment improve care many report willingness answer questions relatively frequently
green building rating systems developed measure level sustainability buildings existing methods applied different regions addressing additional aspects varied climatic conditions regional variations paper investigated widely used environmental building assessment methods namely breeam leed tool casbee leed india griha eco housing comparative studies revealed existing assessment schemes limitations applied indian built environment necessitates development new building environmental assessment scheme attempt made develop framework evaluate sustainability buildings india applying principal component analysis pca pca valid responses attributes measuring sustainability buildings extracted nine components site selection environment building resources use building services management innovative construction techniques environmental health safety mechanical systems indoor air quality economy framework suggested study applied countries similar climatic conditions findings paper helpful designers developers achieve green development developing countries
using porcine model diabetes mellitus hypercholesterolaemia previously showed diabetes mellitus hypercholesterolaemia associated chronic increase blood brain barrier permeability cerebral cortex leading selective binding immunoglobulin deposition amyloid beta peptide pyramidal neurons treatment darapladib glaxosmithkline inhibitor lipoprotein associated phospholipase alleviated effects investigation effects chronic diabetes mellitus hypercholesterolaemia pig retina revealed corresponding increased permeability blood retina barrier coupled leak plasma components retina alterations retinal architecture selective igg binding neurons ganglion cell layer thinning retinal layers due cell loss increased glial fibrillary acidic protein expression muller cells curtailed treatment darapladib findings suggest chronic diabetes mellitus hypercholesterolaemia induces increased blood retina barrier permeability may linked altered expression blood retina barrier associated tight junction proteins claudin occludin leading structural changes retina consistent diabetic retinopathy additionally results suggest drugs vascular anti inflammatory properties darapladib may beneficial effects eye diseases strongly linked vascular abnormalities diabetic retinopathy age related macular degeneration
figure ground segmentation crucial preprocessing step many image processing computer vision tasks since different object classes need specific segmentation rules top approach learns object information suitable solve segmentation problems bottom approach problem faced existing top methods require much human work intervention meanwhile introducing human bias genetic programming require users specify structure solutions apply evolve segmentors conduct figure ground segmentation automatically accurately paper aims determine kind image information necessary evolve capable segmentors especially images high variations varied object shapes cluttered backgrounds therefore seven different terminal sets exploited evolve segmentors images four datasets bitmap brodatz texture weizmann pascal databases increasingly difficult segmentation tasks selected testing results show proposed based method successfully applied diverse types images addition intensity based features sufficient complex images whereas features containing spectral statistical information necessary compared four widely used segmentation techniques method obtains consistently better segmentation performance elsevier rights reserved
wood garb nezworski lilienfeld duke found systematic review meta analyses rorschach variables accurate unbiased hence removed previous recommendation moratorium applied use rorschach however wood hypothesized publication bias would exist rorschach variables test hypothesis replicated meta analyses variables added unpublished dissertations pool articles process used procedures contradicted standards recommendations sound rorschach research consistently led significantly lower effect sizes reviewing meta analyses found numerous methodological errors data errors omitted studies contrast strict requirements interrater reliability rorschach meta analyses researchers report interrater reliability coding classification decisions addition many conclusions based narrative review individual studies post hoc analyses rather meta analytic findings finally challenge sole use dissertations test publication bias failed reconcile conclusion publication bias present analyses conducted showing absence found numerous problems dissertation study quality short one rely findings conclusions reported wood
cds nanoparticles nps decorated alpha feo nanopillar arrays npas fabricated several steps npas firstly fabricated glancing angle deposition technique oxidized air gain alpha feo npas npas decorated cds nps successive ion layer adsorption reaction silar tested photodegredation methylene blue photoelectrochemical properties visible light especially silar cycle number reaches shows highest degradation efficiency min improves comparing pure one highest photocurrent density agcl electrode alpha feo cds hetero junctions could greatly enhance photocatalytic performance help accomplish sufficient usage solar energy exploited pollution abatement future elsevier inc rights reserved
strong movement asserting importance quality education world students ages many educators believe order achieve century skills must taught digital literacy coupled rigorous computer science principles computational thinking accordingly work describe didactic experience introductory programming course describing context pedagogical approach content course based procedure first approach technologies used research questions addressed experimental design adopted data collection analysis main conclusion supported qualitative quantitative data research questions focus understanding best medium design algorithms comparing flow chart scratch programming language evaluating whether using textual language worth effort syntactic burden imposed languages analysis quantitative qualitative data revealed visual programming flow chart approach suitable algorithm design statistical difference terms number errors time taken write corresponding code textual language however high number errors suggest using visual programming allows student focus problem solving activities
since shale gas production data predicted traditional simulators far field test reservoir volume parameters often modified meet fitting demands pressure transient models reservoir merely based darcy flow matrix natural fractures neglect comprehensive influences viscous flow slip flow transition flow knudsen flow etc paper two gas apparent permeability models considering multiple migration mechanisms established theoretical derivation fitting models applicable various flow states help simplify percolation models matrix fracture system achieve better understanding migration mechanisms shale matrix effects compressed gas matrix pores adsorbed gas pore wall diffused gas kerogen transient pressure taken account based newly established gas apparent permeability models pseudo triple medium transient percolation mathematical model multi fractured horizontal well affected multiple migration mechanisms presented consideration dissolved gas diffusion kerogen adsorbed gas desorption matrix surface shale gas reservoir source function idea combined laplace transform linear approximation delta generalized function used get point source solution mathematical model discretizing artificial fractures pressure transient response multi fractured horizontal well laplace space obtained basis point source solution pressure transient response type curves plotted computer programming pressure influence factors also analyzed besides isothermal adsorption experiment data shale cores indicates organic carbon content toc obvious correlation adsorption coefficient defined paper gives clue link exploitation research geological study playing guiding role analyzing pressure response shale gas reservoir elsevier rights reserved
control oriented two timescale linear dynamic response model rotational transform iota profile normalized beta beta proposed based experimental data diii tokamak dedicated system identification experiments without feedback control carried generate data development model data driven dynamic model device specific scenario specific represents response iota profile beta electric field due induction well heating current drive systems flat top phase mode discharge diii control goal use induction systems locally regulate plasma iota profile beta around particular target values close reference state used system identification singular value decomposition svd plasma model steady state carried decouple system identify relevant control channels mixed sensitivity robust control design problem formulated based dynamic model synthesize stabilizing feedback controller without input constraints minimizes reference tracking error rejects external disturbances minimal control energy feedback controller augmented anti windup compensator keeps given controller well behaved presence magnitude constraints actuators leaves nominal closed loop system unmodified saturation present proposed controller represents one first feedback profile controllers integrating magnetic kinetic variables ever implemented experimentally tested diii preliminary experimental results presented work although limited number constrained actuator problems design limitations reported show good progress towards routine current profile control diii leave valuable lessons advancements field elsevier rights reserved
background optimal number health workers appropriately allocated across different occupations geographical regions required ensure population coverage health interventions health worker shortages hiv care provision highest areas worst hit hiv epidemic kenya listed among countries experience health worker shortages health workers per population high hiv burden hiv prevalence nyanza province set determine optimum number clinicians required provide quality consultancy hiv care services jaramogi oginga odinga teaching referral hospital jootrh hiv clinic premier hiv clinic nyanza province cumulative client enrolment plhiv persons case presentation world health organization workload indicators staffing needs wisn used compute staffing needs sufficiency staffing needs jootrh hiv clinic kisumu kenya january december people living hiv plhiv received hiv care services hiv clinic jootrh clinicians attending included analysis actual staffing divided optimal staff requirement give ratios staffing excesses shortages ratio indicated optimal staffing less indicated suboptimal staffing indicated supra optimal staffing hiv clinic served staff various cadres clinicians doctors clinical officers comprise approximately one fifth population clinicians excluding clinic manager engaged administrative duties supervisory roles consumes approximately one third time provide full time consultancy services operate maximum efficiency clinic therefore requires clinicians clinic therefore operates staffing requirements conclusions assessment revealed severe shortage clinicians providing consultation services hiv clinic human resources managers oversee rational planning training retention management human resources health using wisn objective reliable means estimating staffing needs
human prosocial behavior emerges year life posing challenging questions mechanism increasingly common claim prosocial behavior first years life neither result affected socialization article argue early socialization plays critical role developmental origins prosocial behavior support argument highlight conceptual perspectives empirical evidence influences socialization parents reports direct observation experimental studies conclude progress explaining ontogenetic origins human prosocial behavior depends fully specifying mechanisms socialization infancy well human infants learn social experiences
thyroid disorders associated recurrent miscarriage little evidence available influence subclinical hypothyroidism live birth rates cohort study women experienced miscarriage subclinical hypothyroidism defined thyroid stimulating hormone percentile normal thyroxine level investigated control group included women experienced recurrent miscarriage normal thyroid function multivariable logistic regression used investigate association subclinical hypothyroidism data available women subclinical hypothyroidism women euthyroidism overt hypothyroidism live birth rate women subclinical hypothyroidism euthyroid women ongoing pregnancy rate versus miscarriage rate versus respectively differences found thyroid stimulating hormone used cut level define subclinical hypothyroidism women unexplained miscarriage differences found live birth ongoing pregnancy miscarriage rates women subclinical hypothyroidism euthyroid women published elsevier ltd behalf reproductive healthcare ltd
determine malignancy rate overall specific rads descriptors women years undergo stereotactic biopsy calcifications retrospectively reviewed consecutive mammogram reports women years collect stereotactic biopsies calcifications women cases missing images histopathology calcifications associated masses distortion asymmetries excluded three breast radiologists determined rads descriptors majority histology hormone receptor status lymph node status correlated rads descriptors benign atypia lobular carcinomas situ ductal carcinomas situ dcis invasive diagnoses twenty seven dcis cases high grade five invasive cases high grade two triple negative three node positive malignancy found fine pleomorphic fine linear amorphous round coarse heterogeneous dystrophic calcifications among women years underwent stereotactic biopsy calcifications observed high rate malignancy additionally coarse heterogeneous calcifications may warrant probable benign designation aeuro cent cancer rates biopsied calcifications women years high aeuro cent radiologists dismiss suspicious calcifications older women aeuro cent coarse heterogeneous calcifications may warrant probable benign designation
introduce transactions libraries concurrent data structures transactions used ensure atomicity sequences data structure operations focusing transactional access well defined set data structure operations strike balance ease ofprogramming transactions efficiency customtailored data structures exemplify concept designing implementing library supporting transactions number maps sets implemented skiplists queues library offers efficient scalable transactions order magnitude faster state theart transactional memory toolkits moreover approach treats stand alone data structure operations like put enqueue first class citizens allows execute virtually overhead speed original data structure library
patients suffering upper limb deficiency experience significant reduction ability interact environment primary method used restore lost function implementation prosthesis however significant proportion users abandon devices citing reasons cost weight functional control aesthetics paper discuss use myoelectric control technology control additive manufactured myoelectric transradial prosthesis prosthesis low cost lightweight easily controlled morphology mimics human hand part study single channel electromyogram controlled hand model developed using arduino uno microcontroller control single degree freedom preliminary testing debugging indicated single input channel adequate relatively simple open close protocols however order allow fine control desired patients new preprocessing boards need developed arduino order gain access input channels allow truly explore arduino budget option implementing higher complexity control structures
antispasmodic drugs cheap effective generally safe may improve outcomes colonoscopy however use consistent widespread manuscript reviews three commonly used antispasmodics colonoscopy namely hyoscine butylbromide related ammonium compounds glucagon peppermint oil pharmacology action safety agents well evidence improving colonoscopic outcomes discussed addition polyp detection colonoscopic outcome endpoints interest include cecal ileal intubation patient comfort drugs studied found effective gastrointestinal antispasmodics good safety profiles insufficient evidence conclude whether antispasmodics improve cecal intubation rate predominantly baseline rates already high antispasmodics probably efficacy reducing cecal intubation time especially marked colonic spasm antispasmodics offer significant benefit polyp detection improving patient comfort colonoscopy future studies focus inexperienced colonoscopists well marked colonic spasm greatest benefit seems lie
aftercare services part usual care people severe mental disorders iran study performed assess cost effectiveness aftercare services including telephone follow home visit addition caregivers education training social skills subjects months hospital discharge economic evaluation performed along registered randomised controlled trial irctn two groups persons recruited intervention effectiveness measured psychopathology quality life indicators cost effectiveness cost utility analysed societal ministry health moh perspectives indicators psychopathology quality life satisfaction services intervention group significantly different control group mean intervention costs confidence interval per subject intervention group average total direct costs per subject intervention control groups respectively societal perspective intervention effects lower costs ratios incremental cost effectiveness per quality adjusted life year qaly gained moh perspective months follow study showed aftercare services create opportunities use hospital beds efficiently unmet needs people psychiatric disorders indirect intangible costs considered study taken account likely increase efficiency intervention
one side cloud computing offers scalable virtual computing resources form web services pay basis side also raises concerns regarding security threats cloud environment outside inside environment existing security systems able withstand dynamic nature threats sort augmentations required existing security systems enable security systems work prominent way inter attacks possess kind threats inside cloud environment user profiling helpful situation analyzing usage patterns users providing plausible interpretation usage patterns security system security system based interpretations act reactive proactive manner analyzed threat situation paper based findings last paper found designing user profiling system based artificial intelligence techniques fuzzy genetic algorithms individually sufficient deliver comprehensive user profiling system might possible use two approaches hybrid way design comprehensive user profiling system cloud computing security hence used hybrid approach fuzzy guided genetic algorithm design user profiling system found covered research gaps analyzed previous work even fulfill seven principles evaluating framework
background sinusitis leading health care problem believed increasing incidence prevalence various articles published sinusitis treatment however importance diminished fact sinusitis variously defined main objective study define clinical signs symptoms chronic bacterial sinusitis grade severity presentation clinical feature correlating radiological endoscopic microbiological features materials methods prospective study conducted tertiary health care centre three month period patients chosen nasal symptoms main complaint without headache experimental group patients headache main complaint without nasal symptoms control group subjected detailed clinical examination radiological endoscopic microbiological examinations results nasal obstruction discharge headache form major symptoms hyperaemia deviated septum hypertrophied inferior turbinates form major signs case group diagnostic nasal endoscopy correlated well clinical findings ray sinuses found abnormal cases conclusion proper detailed clinical evaluation ray paranasal sinuses endoscopy form mainstay diagnosing chronic bacterial sinusitis scan added planning surgery cases responding initial medical management due radiological risk cause factor
present study examined effectiveness retrieval support witnesses differ working memory capacity wmc source monitoring abilities hypothesised provision retrieval support relative free recall would compensate deficits linked lower working memory source monitoring abilities providing structure context cues retrieval thus expected associations recall performance wmc source monitoring abilities retrieval support group significant positive associations free recall group study combined data two experiments participants either received retrieval support self administered interview completed free recall along working source memory tests contrary expectations presence retrieval support moderate relationship wmc recall performance one two source memory tests higher source memory scores associated accurate accounts retrieval support group whereas free recall group lower source memory scores associated higher recall accuracy suggests individuals lower source memory abilities may benefit retrieval support encourage replication heterogeneous sample
objective study demonstrate effectiveness college course preconception health prenatal development improving reproductive health awareness college students students enrolled course completed pretest posttest assessments course evaluation students self perception awareness positive negative factors affect pregnancy increased beginning course end course respectively correspondingly students knowledge course related information improved across nearly areas assessed average score among students increased correct pretest posttest course evaluation results indicated students found course beneficial informative college courses practical way disseminate reproductive prenatal health information educating college students areas clear benefits individual students society merits increased attention college curricula
annual generation construction waste immense developed developing economies environmental impacts caused disposal waste stream multiple aspects involving soil pollution air pollution water pollution etc meanwhile green building concept becoming popular public hence building developers eager obtain green building certifications increase added value buildings green building rating system gbrs tool evaluating whether particular building green corresponding rank given according detailed assessment requirements previous studies gbrs acted guideline improve energy use indoor air quality however effectiveness gbrs applied construction waste management explored bridge research gap study examines five selected gbrss worldwide proposes comparative analysis attempting give better understanding measures assist improving construction waste management importance construction waste management different gbrss evaluated according accumulation corresponding scores related assessment items furthermore foci construction waste management different gbrss investigated three dimensions based principle referring reduce reuse recycle research findings reveal five rating systems studied highest relative significance index waste management given evaluation standard green building lowest belongs green building index relation principle evaluation standard green building green globes focus reduce principle three systems propose waste management measures largely based reuse recycle principles discussions given based outcomes comparative analysis future research topics suggested well elsevier ltd rights reserved
concept web laboratories remotely controlled laboratory set ups virtual laboratories different simulations important role engineering education training paper presents evaluation fundamental objectives laboratories distance education comparing effectiveness remotely controlled approach versus simulations results analysis show students prefer remotely controlled laboratories compared simulation labs results show remotely controlled laboratories better fulfill objectives important laboratory exercises wiley periodicals inc comput appl eng educ view article online doi
dynamic optimization problems dops attracted increasing attention recent years analyzing fitness landscape essential understand characteristics dops may provide guidance algorithm design existing measures analyzing dynamic fitness landscape dynamic fitness distance correlation severity change give comprehensive evaluation landscape many disadvantages paper used discrete time fourier transform dtft dynamic time warping dtw distance acquire information fitness landscape frequency time domains five measures proposed including stationarity amplitude change keenness periodicity change degree average fitness similarity reflect features fitness landscape aspects outline keenness period fitness value similarity degree respectively criteria obtain essential information acquired existing criteria depend distribution variables prior information solutions algorithms illustrate performance five measures experiments conducted based three types standard dops two peak function addition also apply criteria test task scheduling problem illustrating fairness adaptability experiment results show criteria reflect change characteristics dynamic fitness landscape consistent theoretical analysis elsevier rights reserved
background reports university students using prescription stimulants non medical pharmaceutical cognitive enhancement pce improve alertness focus memory mood attempt manage demands study university purported demand pces academic contexts based incomplete understandings student motivations often based untested assumptions context within stimulants used may represent attempts cope biopsychosocial stressors university life offsetting students inadequate coping responses turn may affect cognitive performance study aimed identify strategies students adopted cope stress university life assess whether students used stimulants pce exhibit particular stress coping patterns methods interviewed university students without pce experience experience managing student life specifically educational values study habits achievement stress management getting assistance competing activities demands health habits cognitive enhancement practices interview transcripts coded themes analyzed results thematic analysis revealed generally self rated coping ability decreased students self rated stress level increased students used emotion problem focused coping part adjustment focused coping lesser extent avoidance emotion focused coping strategy common followed problem focused coping strategies use cognition enhancing substances planning monitoring workload pce users predominantly used avoidant emotion focused coping strategies longer mitigated distress approaching deadlines resulting use prescription stimulants substance based problem focused coping strategy conclusion study suggests students choose coping responses moderate stress possible may cause additional distress avoid learning effective coping responses helping students understand stress coping develop realistic stress appraisal techniques may assist students general maintain manageable distress levels functioning furthermore assisting students may inclined use prescription stimulants cognitive enhancement may reduce possible drug related harms
purpose review review recent data clinical trials descriptions endometrial morphology administration selective progesterone receptor modulators sprms recent findings recent reports concerning administration sprms specifically efficacy ulipristal acetate reducing fibroid size rapid control menstrual blood loss renewed clinical interest class compound histological data studies sprms report class drugs associated progesterone receptor modulator associated endometrial changes data mechanisms action lacking antagonistic progesterone effect sprms shown promising results animal studies endometriosis sex steroid receptor effects prms outside reproductive tract raise potential use neurology oncology although several randomized trials areas limited small studies published date summary sprm ulipristal acetate effective treatment preoperative treatment fibroids reliable emergency contraceptive class compounds holds potential long term effective medical management fibroids may utility management sex steroid dependent conditions
background anxiety disorders leading cause mental illness adolescence anxious adolescents show impairments emotion processing deficits emotion regulation studies attempted improve emotion regulation within populations method study used multi method design test newly developed emotion regulation training aimed improving insight emotions instructing cognitive reappraisal efficacy cognitive reappraisal investigated clinically anxious youth age healthy controls age using psychophysiological measures specifically heart rate variability pupil dilation visual fixations recorded youth downregulate emotions response affective pictures psychophysiological indicators emotion regulation pier task results novel training effectively improved self reported emotion regulation momentary anxiety groups moreover initial group differences emotional reactivity mostly disappeared participants instructed apply emotion regulation task however pupil dilation data suggested participants anxiety disorders required cognitive resources upregulation negative affect counteract effect limitations relatively small sample size large age range could hamper detection additional group differences may exist conclusions current study provides evidence anxious youth apply cognitive reappraisal similar extent healthy adolescents emotion regulation training may need exert effort training could valuable addition current treatment programs
paper examines closed loop characteristics basic current feedback operational amplifier cfoa particular dynamic response additionally also examines design advantages cfoa regarding ability provide significantly constant closed loop bandwidth closed loop voltage gain secondly almost limitless slew rate provided class input stage makes superior voltage mode operational amplifier voa counterpart additionally paper also concerns definitions measurements terminal parameters cfoa regarded black box deal way parameters related properties active passive active components particular circuit configuration simulation used terminal parameter determination brings facility using test conditions would normally prevail laboratory test silicon implementations cfoas thus apply test signals respectively infinite zero source impedances range frequency tens ghz also assume existence resistors identical ohmic value high value ideal capacitors appropriate practical test methods referred physical laboratory prototypes
ongoing economic development lifestyle changes aging population diabetes mellitus come one prevalent chronic diseases world rhino orbito cerebral roc mucormycosis rare acute angioinvasive fungal infection fatal mucormycosis occurs exclusively immunocompromised patients diabetes mellitus types immunodeficiency three subtypes rhino maxillary rhino orbital roc mucormycosis present study reported case roc mucormycosis patient diabetic ketoacidosis present case pathogen afflicted organs including left eye nasal cavity hard palate cerebrum
modern construction projects developing toward large scale complicated making traditional project management methods unable meet needs integrated management project inevitable trend modern construction management also necessary condition projects success paper author built integrated management system framework model analyzing significance integrated management explore implementation approaches integrated management provide new ideas promote reform innovation construction management
invertebrates inhabiting marine freshwater ecosystems make important contributions global biodiversity provide significant services cascading effects across ecosystems however group grossly represented assessments conservation status often neglected targeted aquatic conservation efforts global assessments freshwater invertebrates marine invertebrates considered data deficient highlighting paucity information making assessments invertebrate groups could assessed poor dispersal abilities high local endemism many gastropods crayfish mussels threatened springs subterranean hydrological systems support highest proportions threatened freshwater species marine environments coral reefs lagoons anchialine systems particularly vulnerable key agents biodiversity decline aquatic ecosystems water pollution overexploitation harvesting habitat degradation destruction alien invasive species climate change effects dams water management along pollution urban agricultural forestry sources main threats freshwater ecosystems whereas broad range factors impacts marine invertebrates including biological resource use significant impediments facing conservation aquatic invertebrates limited knowledge diversity need broadscale actions account connectivity within across ecosystems lack political investment prospect conditions may get worse improve possibly time save already highly imperilled invertebrate species extinction copyright john wiley sons ltd
background cox expression induces carcinogenesis thought adverse prognostic factor gastric carcinomas prognostic value dna mismatch repair mmr still controversial concerning adenocarcinomas esophagogastric junction comprehensive data regarding either factors available yet objective assessed expression cox mlh msh adenocarcinoma esophagogastric junction relation patients survival various clinicopathologic features design immunohistochemical studies using antibodies cox mlh msh performed study population tumours followup data available patients mean follow time months results tumours cox negative showed cox positivity assessment cox expression clinicopathologic features revealed inverse correlation depth tumour invasion number metastatic lymph nodes respectively correlation features could demonstrated cases showed loss dna repair enzymes mlh msh mmr differed significantly cox positive negative cases kaplan meier survival analyses revealed impact patients survival cox expression mmr status respectively conclusions expression cox adenocarcinomas esophagogastric junction seems prognostic effect impact patients survival associated favourable clinico pathologic factors mmr deficiency frequent cox negative tumours mmr status impact survival patients outcome whatsoever
controller design aspect automatic generation control agc multi area power system often regarded optimization problem different conflicting objectives controller must fulfill objectives produce feasible set solution per requirements designer paper explores design performance analysis proportional integral derivative pid controller employing jaya algorithm agc interconnected power system filter derivative term used pid controller minimize effect noise input signal different performance measures considered integral time multiplied absolute error itae minimization peak overshoots settling times deviations frequencies tie line power furthermore performance measures objectives combined form single objective problem using analytic hierarchy process ahp recently proposed jaya algorithm free algorithm specific parameters used minimizing single objective two area interconnected linear power system model considered simulation process simulation studies carried five different cases diverse sets disturbances efficacy superiority proposed jaya algorithm based pid controller shown comparing simulation results algorithms like particle swarm optimization pso differential evolution nelder mead simplex nms elephant herding optimization eho teacher learner based optimization tlbo time domain simulations statistical analysis presented validate effectiveness proposed controller
introduction bone repair frequently requires time consuming implant construction particularly using formed implants poor handling properties wetherefore developed osteoinductive micro fibrous surface patterned demineralized bone matrix dbm fibers engineering defect matched general three dimensional implants methods results implant molds filled demineralized human cortical bone fibers compressed lyophilized forming mechanically strong shaped dbm scaffolds enzyme linked immunosorbent assays mass spectrometry confirmed dbm fibers contained abundant osteogenic growth factors bone morphogenetic proteins insulin like growth factor extracellular matrix proteins mercury porosimetry mechanical testing showed interconnected pores within mechanically stable custom dbm fiber scaffolds mesenchymal stem cells readily attached dbm showed increasing metabolic activity time dbm fibers increased alkaline phosphatase activity cells vivo dbm implants elicited osteoinductive potential mouse muscle pouch also promoted spine fusion rat arthrodesis model significance dbm fibers engineered custom shaped osteoinductive osteoconductive implants potential repairing osseous defects precise fitment potentially reducing operating time providing pre formed custom implants regenerative allograft may improve patient outcomes following surgical bone repair advancing personalized orthopedic craniomaxillofacial medicine using three dimensional printed tissue molds
objective bradykinin mediated angioedema characterized transient attacks localized edema subcutaneous submucosal tissues life threatening involving upper airways aim study determine features acute attacks might associated admission icu patients methods carried retrospective multicenter observational study consecutive patients attending one six reference centers france acute bradykinin mediated angioedema attacks patients hospitalized acute episode least previously acute attacks requiring icu admission compared acute attacks required icu admission results overall acute attacks patients analyzed patients hereditary angioedema patients angiotensin converting enzyme inhibitor induced angioedema two patients acquired inhibitor deficiency angioedema multivariate analysis upper airway involvement corticosteroid inhibitor concentrate administration associated icu admission seven episodes needed airway protection evolution favorable attacks warranting icu admission patients able get service mean icu stay days one death observed asphyxiation laryngeal swelling conclusion upper airway involvement independent risk factor icu admission corticosteroid use ineffective treatment inhibitor concentrate use factors icu admission presence upper airway involvement warning signal attack may severe copyright wolters kluwer health inc rights reserved
background genetic regulation apoptosis cell proliferation plays role growth chronic lymphocytic leukemia cll common form leukemia western hemisphere although thyroid hormone receptor interactors trips known play roles cell cycle potential involvement novel family member trip cll yet investigated methods quantitative pcr qpcr used detect expression trip cll patients healthy donors cells loss function sirna assays used alter trip expression levels effect trip cell proliferation apoptosis measured mtt annexin based flow cytometry caspase activity assay affymetrix genechip ingenuity pathway analysis ipa used describe overview trip potential biological function downstream pathways dual luciferase reporter assay performed assess promoting effect myc trip transcription results qpcr data showed trip significantly expressed cll patients microarray analyses indicated biological function trip cll majorly cell apoptosis cell proliferation associated trip sirna expressing cells exhibited slower cell proliferation rate underwent apoptosis compared control cells trip knockdown induced cll cells apoptosis puma independent trip regulation induced myc dependent transcriptional activation conclusion overall data suggest bio function trip cll cell first time gene might therapeutic target cll
artificial neural networks effectively used various civil engineering fields including construction management labour productivity study performance feed forward neural network ffnn compared radial basis neural network rbnn modelling productivity masonry crews variety input factors incorporated analysed mean absolute percentage error mape correlation coefficient used evaluate model performance research results indicated neural computing techniques could successfully employed modelling crew productivity also found successful models could developed different combinations input factors several models excluded one input factors turned better baseline models based mape values obtained models rbnn technique found better ffnn technique although slightly overestimated masons productivity
deficiency rapid field detection methods portable devices reliable easy use low cost results difficulties uphold high safety standards china study introduce rapid cost effective smartphone based method point need food safety inspection employs aptamer conjugated aunps colorimetric indicator battery powered optosensing accessory attached camera smartphone transmission images capture userfriendly easy use android application developed automatic digital image processing result reporting streptomycin str selected proof concept target specific quantitation realized lod using reported smartphone based method quantitation str honey milk tap water confirm reliability applicability reported method extremely high acceptance smartphone remote metropolitan areas china ease use reported method facilitate active food contaminant toxicant screening thus making implementation whole food supply chain monitoring surveillance possible hence significantly improving current chinese food safety control system elsevier rights reserved
hyper activation pak activated kinase frequently observed human cancer speculated target novel anti tumor drug previous also showed pak highly activated smad deficient condition suppresses puma upregulated modulator apoptosis direct binding phosphorylation basis result tried find novel pak puma binding inhibitors elisa based blind chemical library screening isolated single compound ipp ipp inhibitor pak puma selectively blocks pak puma binding also suppresses cell proliferation via pumadependent manner indeed puma deficient cells chemical show anti proliferating effect chemical possessed strong pak inhibition activity suppressed bad bcl asoociated death promoter phosphorylation meta phase arrest via aurora kinase inactivation lower concentration previous pak kinase frax moreover chemical obviously induced waf cip cyclin dependent kinase inhibitor expression releasing bcl cell lymphoma inhibition akt mediated suppression considering result ipp derivatives would possible candidates pak induction targeted anti cancer drug
objective maternal depression affects mothers young children negative consequences children health development american academy pediatrics aap recommends pediatricians identify women maternal depression authors examined trends inquiring asking informal questions screening using standardized instrument maternal depression pediatricians identified correlates usually inquiring screening identify maternal depression methods data ascertained nontrainee pediatricians exclusively practicing general pediatrics completed aap periodic surveys pediatricians answered questions physician practice characteristics training attitudes inquiring screening identify maternal depression sample weights used reduce nonresponse bias weighted descriptive logistic regression analyses conducted results prevalence usually inquiring screening identify maternal depression increased years pediatricians usually inquired child adolescent depression increased odds usually inquiring screening identify maternal depression patient race ethnicity training adult diagnostic statistical manual mental disorders dsm diagnostic criteria depression associated inquiring screening believing family screening within scope pediatrician associated inquiring screening conclusion although inquiring screening maternal depression increased since less half pediatricians usually screen inquire maternal depression representing missed opportunity identify depression manage refer women treatment training importance mental family health children health may increase identification maternal depression pediatric primary care
tini shape memory alloys smas used long term implant materials disadvantage ion release alloys may trigger allergies human body micro arc oxidation utilized modify surface tini sma improving corrosion resistance biocompatibility however reports investigating essential adhesive strength micro arc oxidized film tini sma two primary goals attained study first tini sma phase transformation temperature less body temperature good shape recovery prepared next tini tini sma surfaces modified micro arc oxidation phosphoric acid applying relatively low voltages maintain adhesive strength results indicated pore size film thickness content increased applied voltage micro arc oxidized film comprising oxides oxide phosphate compounds exhibited glassy amorphous structure outmost surface micro arc oxidized film contained large amount trace adhesive strengths micro arc oxidized films exceeded requirements iso furthermore addition tini smas found favorable improving adhesive strength micro arc oxidized film elsevier rights reserved
study concerns bangladeshi male migrant workers malaysia examines living working condition migrants adapt blurring gender roles malaysia total bangladeshi male migrant workers interviewed questionnaire covering causes migration problems face perceptions toward gender roles household tasks family results show varieties factors compel men migrate malaysia earning money improving standard living common reason given face numerous problems everyday lives work living environment study highlights migration occurs household livelihood strategy besides migration also contribute toward negotiated transnationalist identity circumstances require transcend normative gender roles patriarchal norms remain strongly normalized despite blurring gendered roles migration process
current increase deployment new renewable electricity generation systems creating new challenges balancing electric grids solutions including energy storage small large scales becoming paramount importance guarantee secure stable supply electricity paper presents study hybrid solution including large scale energy storage system coupled power generation fast responding energy storage systems hybrid plant able deliver energy previously stored using air liquefaction process either without contribution additional energy combustion paper also highlights hybrid plants may offer chance providing grid fast control services ideal energy storage technology high power rating large storage capacity high efficiency low costs geographic constraints use air energy carrier studied since century first compressed air energy storage caes systems technology still considered potential geographically constrained suitable geological reservoirs available unless compressed air stored pressurized tanks significant costs liquid air energy storage laes represents interesting solution due relatively large volumetric energy density ease storage different process schemes hybrid plants modeled study aspen hysys simulation software results compared terms equivalent round trip fuel efficiencies equivalent round trip efficiencies higher calculated showing proposed configurations might play important role power systems balancing near future elsevier ltd rights reserved
background amplatzer occluder cardio fix occluder currently used percutaneous closure patent foramen ovale however still lack relevant reports comparison differences aim study evaluate short term mid term safety efficacy cardi fix occluder preventing recurrent cerebrovascular events patients patent foramen ovale pfo methods enrolled patients men pfo may march single center prospective study patients treated pfo interventional closure cardi fix pfo occluder used patients amplatzer pfo occluder utilized remaining patients procedure verified safety efficacy different devices using contrast transthoracic echocardiography results neither recurrent stroke death encountered follow months transient ischemic attack tia noted patients cardi fix pfo occluder group patient suffered tia amplatzer pfo occluder group among patient exhibited small right left shunt rls statistical difference recurrent cerebral ischemic events three cases paroxysmal atrial fibrillation observed cardi fix pfo occluder group one reverted spontaneously sinus rhythm cases pharmacologic conversion sinus rhythm one case paroxysmal atrial fibrillation occurred amplatzer group underwent pharmacologic conversion sinus rhythm significant difference groups regarding incidence arrhythmia occluder translocation erosion pericardial effusion puncture site bleeding observed groups within months follow complete closure rates cardi fix amplatzer pfo occluder devices months procedure respectively effective closure rates respectively statistically significant difference complete closure rate effective occlusion rate devices conclusions significant difference short mid term efficacy safety cardi fix pfo occluder amplatzer pfo occluder efficacy safety cardi fix occluder comparable amplatzer pfo occluder
display quality rendering head mounted displays hmds increased quality performance interaction capabilities devices still limited relying expensive technology current experiences offered mobile hmds often stick dome like looking around automatic gaze triggered movement flying techniques developed easy use walking place technique require additional hardware enable basic navigation walking running jumping virtual environments approach based analysis data inertial unit embedded mobile hmds first prototype realized samsung galaxy gear detect steps jumps user study shows users novice virtual reality easily pick method comparison classic input device using walking place technique study participants felt present virtual environment preferred method exploration virtual world
ion channels pumps essential regulators organ homeostasis disease present review discuss role mechanosensitive cation channel transient receptor potential vanilloid trpv cytokine secretion pulmonary inflammatory diseases asthma cystic fibrosis acute lung injury acute respiratory distress syndrome ards trpv shown play role lung diseases associated lung parenchymal stretch stiffness trpv indirectly mediates hypotonicity induced smooth muscle contraction airway remodeling asthma literature suggests trpv may improve ciliary beat frequency enhancing mucociliary clearance time increasing pro inflammatory cytokine secretion lung tissue injury currently understood role trpv immune cell function associated lung tissue injury ards may depend injury stimulus uncovering downstream mechanisms trpv action pulmonary inflammatory diseases likely important understanding disease pathogenesis may lead novel therapeutics
treatment bipolar disorder often results patients taking several drugs attempt alleviate residual depressive symptoms lead accumulation side effects new treatments bipolar depression increase side effect burden needed one nonpharmacological treatment side effects bright light therapy shown effective therapy seasonal affective disorder yet extensively studied forms depression forty four adults bipolar disorder depressed phase randomized treatment bright light therapy low density high density negative ion generator weeks primary measure efficacy structured interview guide hamilton depression rating scale atypical depression supplement sigh ads adverse events assessed using young mania rating scale ymrs systematic assessment treatment emergent effects saftee outcome variables statistically analyzed using mixed model repeated measure analysis variance anova results showed statistically significant differences groups outcome measures study end point adverse events including switches hypomania rare research needed determine efficacy bright light therapy population elsevier ireland ltd rights reserved
high order arx models used approximate quite general class linear systems parametric model structure well established methods used retrieve true plant noise models arx polynomials however commonly used approach valid plant stable unstable poles shared true noise model contribution generalize approach allow unstable poles shared introducing modifications correctly retrieve noise model noise variance elsevier ltd rights reserved
effect dietary inclusion white lupin seed wls milk composition yield rabbit well performance litters studied two lactation diets identical digestible protein ratio two weaning diets identical ratio formulated first lactation diet contained soybean meal sbm sunflower meal main sources whereas second lactation diet based wls result diet greater ether extract content diet first weaning diet included sbm main source whereas second weaning diet diet based wls additional fat added diets total per treatment hyplus second parturition fed lactation diets litters standardized kits day birth fed weaning diets age age weaning rabbits weaning diet per cage used evaluate performance feed intake doe affected dietary treatments milk yield tended higher lactation fed diet finding related higher dietary content intake diet expressed per kilogram metabolic weight milk output fat output greater improved lactation greater adg milk efficiency litters observed fed diet milk fed diet contained less linoleic acid arachidonic acid oleic acid alpha linolenic acid eicosapentaenic acid corresponding increase total pufa ratio performance fattening rabbits affected dietary treatment number ill plus dead rabbits caused digestive disease lower rabbits fed diet therefore wls suitable dietary source lactating replace traditionally used sources without adverse effects feed intake milk yield growth viability litters due fatty acid composition use wls lactation diet potential improve milk composition
forest fire started august several places madeira island causing damage casualties august local media reported death three people people injured habitants evacuated houses damaged study presents preliminary results assessment several spectral indices evaluate burn severity madeira fires august spectral indices calculated using new european satellite sentinel launched june study confirmed advantages several spectral indices normalized difference vegetation index ndvi green normalized difference vegetation index gndvi normalized burn ratio nbr normalized difference vegetation index ndvirexn using red edge spectral bands assess post fire conditions results showed high correlation ndvi gndvi nbr ndvireln spectral indices analysis performed copernicus emergency management service emsr considered reference truth regarding red edge spectral indices ndvireln using band presented better results compared bands preliminary results allow assume sentinel valuable tool post fire monitoring future two twin sentinel satellites offer global coverage madeira archipelago every five days therefore allowing simultaneous study evolution burnt area reforestation information high spatial temporal resolution days elsevier rights reserved
water erosion causes soil degradation nonpoint pollution pollutants primarily transported surfaces fine soil sediment particles several soil loss models empirical equations developed size distribution estimation sediment leaving field including physically based models empirical equations usually physically based models require large amount data sometimes exceeding amount available data modeled area conversely empirical equations always predict sediment composition associated individual events may require data always available therefore objective study develop model predict particle size distribution psd eroded soil total erosion events soils used data compiled previous studies correlation multiple regression analyses used identify main variables controlling sediment psd variables particle size distribution soil matrix antecedent soil moisture condition soil erodibility hillslope geometry variables artificial neural network calibrated using data events sand silt clay sediment respectively validated tested events sand silt clay sediment respectively artificial neural network compared three empirical models network presented better performance predicting sediment psd differentiating rain runoff events soil addition quality particle distribution estimates model requires small number easily obtained variables providing convenient routine predicting psd eroded sediment pollutant transport models elsevier rights reserved
aim study examine relationship mode coping health related quality life hrqol patients migraine also tried examine relationship disease duration frequency attacks hrqol ways coping stress research done sample consisting participants women men mean age years iqr migraine lasting years irq years average number attacks last month two attacks irq attacks ways coping questionnaire used estimate mode coping stress questionnaire hrqol result showed self control common way coping stress patients migraine also confirmed existence significant connection ways coping stress hrqol people migraine larger number significant correlations ways coping connected domains mental health physical health escape avoidance significantly negatively correlated largest number hrqol domains especially existence significant mental health rho role limitation due emotional problems rho number migraine attacks greater influence hrqol patients migraine disease duration study showed existence significant correlations ways coping stress hrqol especially mental domains domains correlation even stronger one showing disease duration number attacks mentioned results suggest directions formulation psychological interventions would helpful additional treatment migraine
background since introduction anti tumour necrosis factor tnf therapy inflammatory diseases paradoxical reactions increasingly reported one paradoxical reactions development sarcoidosis like lesions presentation paradoxical since anti tnf therapy also therapeutic refractory cases sarcoidosis methods report two cases sarcoidosis like lesions anti tnf therapy patients inflammatory bowel disease ibd treated successfully adalimumab next reviewed literature similar cases medical subject heading terms adalimumab infliximab etanercept golimumab certolizumab sarcoidosis used perform key word searches pubmed database results identified reported cases sarcoidosis like lesions developed anti tnf therapy cases anti tnf drug involved etanercept median age years predominance female patients underlying disease rheumatoid arthritis cases followed ankylosing spondylitis psoriasiform arthritis six cases underlying disease ibd cases least partial resolution discontinuation anti tnf treatment initiation steroids initiation anti tnf therapy gave relapse seven cases conclusion sarcoidosis like lesions increasingly reported anti tnf treatment vigilance appropriate patients present symptoms compatible sarcoidosis
paper proposes novel radiometric compensation technique cooperative projection system based distributed optimization achieve high scalability robustness assume cooperative projection environments projector information projectors well target images camera information projectors either target images broadcast communication camera projectors allowed suppress data transfer bandwidth end first investigate distributed optimization based feedback mechanism suitable required decentralized information processing environment next show mechanism works well still image projection however necessary moving images due lack dynamic responsiveness overcome issue propose implement additional feedforward mechanism degree freedom dof control structure well known control engineering community typical method enhance disturbance rejection also reference tracking capability simultaneously theoretically guarantee experimentally demonstrate dof structure yields moving image projection accuracy overwhelming best achievable performance distributed optimization mechanisms
aiming automatic sound recognizer radio broadcasting events methodology clustering audio feature space using discrimination ability audio descriptors criterion investigated work given close set audio events commonly found broadcast news transmissions large set audio descriptors extracted data driven ranking relevance clustered providing robust feature selection clusters feature space feeding machine learning algorithms implemented classification models experimental evaluation methodology showed support vector machines provide significantly good results considering achieved accuracy due ability coping well high dimensionality experimental conditions
hypothesized novel thiolated chitosan coated multilayer microparticles mps enhanced drug loading mucoadhesive uncoated mps safe vivo vaginal delivery topical anti hiv microbicide formulation optimization achieved custom experimental design alginate mps cores prepared using spray drying method optimal mps coated thiolated chitosan tcs using layer layer method morphological analysis situ drug payload vitro drug release profile mucoadhesion potential mps carried using scanning electron microscopy solid state nmr spectroscopy spectroscopy fluorescence imaging periodic acid schiff method respectively cytotoxicity preclinical safety mps assessed human vaginal endocervical end epithelial cell lines female cbl mice respectively results show mps successfully formulated average diameter ranging drug loading drug release profile mps primarily follows baker lonsdale korsmeyer peppas models mps exhibit high mucoadhesion folds compared native agmps multilayer mps noncytotoxic histological immunochemical analysis mice genital tract shows neither signs damage inflammatory cell infiltrate data highlight potential use tcs coated based multilayer mps templates topical vaginal delivery anti hiv aids microbicides
proportional integral differentiator pid widely used industrial control applications digital pid complicated consists many stages paper introduces design analog pid controller using single active element implemented cmos technology pid tested using three structures two stage operational amplifier common source buffer stage folded cascade operational transconductance amplifier second generation current conveyer ccii results taken three methods compared using frequency response transient response parameters
introduction intensive care unit icu dynamic complex learning environment wide range trainee experience specialty training fluctuations patient acuity volume limitations trainee duty hours additional responsibilities faculty contribute challenge providing consistent experience traditional educational strategies flipped classroom educational model potential improve learning environment paradigm students gain exposure new material outside class use class time assimilate knowledge problem solving exercises discussion rationale pedagogical foundations flipped classroom reviewed practical considerations discussed example successful implementation provided methods education curriculum devised evaluated prospectively teaching point care echocardiography residents rotating surgical icu results preintervention postintervention scores knowledge confidence perceived usefulness likelihood use skills improved module quality experience rated highly sessions conclusion flipped classroom education curriculum many advantages pilot study well received learners showed improvement areas evaluated across several demographic subgroups self identified learning styles
introductionthe workup lymphoproliferative disorders lpds involves combined use flow cytometry immunohistochemistry ihc often results duplicate immunophenotypic testing adds costs may eligible reimbursement based medicare national correct coding initiative aimed establish cost effective diagnostic algorithm based initial categorization reduce repetitive immunophenotyping methodswe retrospectively reviewed cases suspected lpds concurrent ihc testing month period correlated surgical diagnoses evaluated frequency repeat ihc testing resultsrepetitive immunophenotyping common overall cases least one marker repeated concordant cases significantly less likely markers repeated discordant cases concordant cell malignancies represented recurrent disease however repeat marker usage decreased compared new diagnoses frequently repeated markers conclusionswe propose concordant cases repeated ihc would decrease use markers respectively developed algorithmic approach ihc usage improved incorporation data institution may reduce healthcare costs
community academic research partnerships aim build stakeholder trust order improve reach translation health research limited empirical research regarding effective ways build trust multisite study launched identify similarities differences among stakeholders perspectives antecedents trust research partnerships conducted mixed methods concept mapping study participants three major stakeholder groups identified rated importance different antecedents trust point likert type scale study participants community members health care providers academic researchers stakeholder groups rated authentic communication reciprocal relationships highest importance community members rated communication methodology resolve problems significantly higher academic researchers health care providers different perspectives regarding importance issues related sustainability importance communication relationships across stakeholders indicates importance colearning processes involve exchange knowledge skills differences uncovered suggest specific areas attention skill building may needed improve trust within partnerships research partnerships improve communication specific problem solving sustainability merited
present study examined whether bullying defending outsider behaviors preschool children associated two conscience aspects empathic concern internalization rules emotion understanding also investigated whether emotion understanding moderated relationship dimensions bullying roles participants children males aged months bullying roles assessed peer nominations internalization rules empathic concern observed classroom scores derived selected sort items emotion understanding evaluated puppet interview administered children results showed empathic concern internalization rules negatively associated bullying outsider behaviors whereas emotion understanding correlated defending behavior interaction emotion understanding internalization rules also significant low scores rule compatible conduct associated bullying outsider behavior particular children poor emotion understanding
large number scientific literature difficult search set relevant articles rank work propose generalized network analysis approach called star ranking model sorting based ranking result considered mutual relationships another classes keyword publication citation model propose two ranks problem universal publication rank rank topic publication rank rank also study two simple ranks based citation counting rcc rank content matching rcm rank propose metrics ranking comparison analysis two criteria value order conducted experimentations confirming predictions studying features ranks results show proposed ranks impressive given problem since consider query topic content publication citations ranking model
backgroundthis analysis myeloproliferative neoplasm mpn landmark survey evaluated gaps patient perceptions disease management physician self reported practices methodsthe survey included patient respondents mpns myelofibrosis polycythemia vera essential thrombocythemia hematologist oncologist respondents treated patients conditions resultsgreater proportions physician respondents reported using prognostic risk classifications compared patient recollections physician respondents reported typical symptom assessments included asking patients important symptoms full list symptoms whereas many patient respondents reported less specific assessments asked feeling many patient respondents recognize common symptoms mpn related example approximately one half believe difficulty sleeping resulted mpn physician respondents underestimated proportion patients symptomatic diagnosis compared patient respondents discordance regarding treatment goals among patient respondents slow delay progression condition important treatment goal whereas physician respondents reported symptom improvement prevention vascular thrombotic events respectively finally one third patient respondents satisfied physician overall management communication conclusionsthe care satisfaction patients mpn may improved increased patient education improved patient physician communication cancer authors cancer published wiley periodicals inc behalf american cancer society analysis data myeloproliferative neoplasm mpn landmark survey identified important gaps patient physician respondent perceptions mpns discordance patient physician respondent perceptions observed mpn related prognostic risk assessment symptom burden treatment goals expectations treatment satisfaction
aims study aimed investigate whether repeated lifestyle interventions lead progressive weight loss weight cycling methods retrospective review chart study follow participants mean age years body weight fat participated one four week lifestyle interventions residential weight loss programme mixed activities weight loss promoted hypocaloric diet kcal day daily physical activity hours day primary outcomes weight loss change body composition bioimpedance measurements intervention periods follow results total people participated one four interventions mean sem times start follow years respectively overall participants lost follow one four interventions respectively cumulated weight loss follow increased number interventions one four ratios cumulated loss fat fat free mass one four interventions decreased number interventions rates weight loss interventions ranged week maximum weight regain follow periods week conclusions repeated relatively short lifestyle interventions selected motivated group efficient method weight loss maintenance limited body weight cycling interim periods however relationship loss fat fat free mass might change unfavourable direction
supreme court brown entertainment merchants association overturned california law sought keep violent video games away minors entertainment software association esa video game industry trade organization years fought legislation aimed providing parents information extremely violent games article analyzes campaign finance records lobbying reports trade publications court documents illustrate esa uses power influence regulatory legislative judicial process documenting political economic influence article charts interrelated developments regarding consolidation ownership growth corporate video game lobby assesses esa political contributions marginalize public access information violent games
one dramatic advance human immunodeficiency virus hiv prevention efforts prescription medications typically used hiv treatment prophylaxis acquiring hiv preventative agent practice referred preexposure prophylaxis prep federal drug administration approved daily prep adults risk hiv consistently use condoms sex hiv infected unknown status partners paper describe cognitive behavioral therapy cbt prep adherence intervention developed use high risk sexual minority men united states adapted life steps evidence based cbt intervention promote adherence hiv treatment modules include creating prep dosing schedule adhering daily prep problem solving barriers adherence sexual risk reduction techniques supplemented practical video vignettes novel intervention may help enhance clinical practice health care providers outpatient settings increase prep adherence sexual minority men
paper investigates stability principle underlying underactuated compass gait generated strict output following control hip joint angle first introduce planar underactuated compass like biped robot semicircular feet develop mathematical model linearize equation motion design output following control relative hip joint angle linearized model second analytically derive transition function state error stance phase based state space representation discuss physical meaning also mathematically show collision phase always stable finally validity theoretical results verified numerical simulations
article examines emissions combustion biodiesel diesel blend stationary internal combustion engines generate electricity emissions analyzed according feedstock used biodiesel production soybean oil palm oil waste frying oil methyl ethyl routes chosen blends composed petroleum diesel biodiesel latter accounting blend results analyzed using tukey test showed general higher engine loads led decrease emissions comparison standard biodiesel blend mandated brazil therefore paper provides original complete approach analyze compare pairs results emissions different biodiesel production routes feedstocks engine loads order find best blend option load level
background type diabetes mellitus tdm epidemic disease around world recently identified risk factor osteoporosis associated fracture however consensus best method assessing fracture risk patients tdm aim study evaluate usefulness osteoporosis self assessment tool asians osta singh index hip fracture risk assessment patients tdm methods enrolled postmenopausal women tdm hip fracture resulting low energy trauma age matched controls fracture two controls per fracture case bone mineral density bmd measured dual energy ray absorptiometry lumbar spine hip region obtained standard antero posterior radiographs pelvis osta calculated formula based weight age data analyzed descriptive statistics tests difference receiver operating characteristic analysis used determine optimum cutoff values sensitivity specificity screening methods discriminative abilities different screening tools compared area curve auc results significant differences bmd sites lumbar spine femoral neck trochanter total hip fracture non fracture groups rho area curve lumbar spine bmd total hip bmd femoral neck bmd trochanter bmd osta osta plus auc combined osta plus significantly superior parameters besides bmd lumbar spine conclusions combination osta plus could clinical alternative tool screening hip fracture risk large diabetic populations tests inexpensive simple perform could especially useful areas bmd measurement accessible
positive youth development critical african american youth negotiate social political historical landscape grounded systemic inequities racism one possible yet understudied approach promote positive youth development increase african american youth consciousness connection africentric values culture primary purpose article investigate degree cultural group consciousness factors cultural orientation africentric values racial socialization predicted positive youth development future orientation prosocial behavior political community social justice equality civic mindedness might differ gender article utilized survey data african american youth participants pen pencil mentoring program results generally indicated cultural orientation africentric values lesser degree racial socialization predicted positive youth development variables effects varying gender findings suggest enhancing cultural consciousness may support positive development african american youth although male female youth may respond efforts different ways
paper presents three case histories retaining earth structure failures indonesia remedy triggering problem analyzed discussed finally design procedure remedial structure reinforced slope using geosynthetic discussed simple guidelines proposed selection geosynthetic reinforcement types system first case river side slope located bali retaining earth structure height constructed using soldier piles rainy season river front structure flooded increased pore water pressure behind rapid draw process river water collapsed soldier pile structure solution combining high strength composite geotextile reinforcement gabion facing chosen successfully executed second case also river side slope located south sumatra previous structure sheetpile sheetpiles pushed filling work even carried solution using polyester geogrid analyzed proposed geogrid elements installed behind existing sheetpile without removing change geogrid reinforced gabion remedial work successful system applied solve problems similar nature project third case cutting slope located west java existing area almost flat height difference surrounding area consists expansive soil clay shale development purposes area cut leaving slope strengthened woven geotextile unfortunately several weeks project completion failed proposed solution using material submitted considering several additional technical aspects based studies concluded retaining earth structures done several different materials approaches long applied right conditions bearing mind different influential factor involved
coronary artery disease cad still common killer western women coronary arteries expressing estrogen receptors target estrogen action prior women health initiative whi study postmenopausal hormone therapy widely advocated primary prevention cad use criticized whi publication however new data accumulated usa europe indicate use estradiol based regimens endanger heart rather significantly reduces incidence cad events mortality effect may related presence hot flushes initiation may indicate greater responsiveness cardiovascular system get maximal cardioprotective efficacy woman initiate soon symptoms occur preferably within first postmenopausal years recent guidelines optimal use recommend pauses year intervals see whether hot flushes symptoms still persist however new data question safety policy acute withdrawals estradiol circulation may predispose potentially fatal cad events data support modernized guidelines optimal use
ferruccio busoni championed frederic chopin music yet performances often elicited responses shock amusement rebelled prevalent sentimental style interpretation associated effeminate chopin even staunchest admirers trouble appreciating unprompted repeats measures structural wholes preludes etudes registral alterations overly intellectualized approach also unusual choice program preludes complete cycle scholars documented busoni interpretive eccentricities rationale behind significance evolution chopin interpretation twentieth century remains largely unexplored analyses recordings concert programs recital reviews busoni little known unpublished essay titled chopin eine ansicht fiber ihn connect busoni unconventional chopin interpretations idiosyncratic perception chopin character nineteenth century chopin music commonly viewed effeminate androgynous childish sickly ethnically busoni essay indicates considered chopin music poetic feminine emotive problematic busoni obsessed manliness age gender roles gradually changing discovered half manly half dramatic elements music chopin character heroic monumental side striving portray whole chopin music distancing gendered halfness earlier writings busoni became pioneer bolder chopin interpretation monumentalist programming portrait chopin reveals cultural ideas inform evolution performers interpretations
paper robust control technique based synthesis employed order investigate vibration control funnel shaped structure used inlet magnetic resonance imaging mri device mri devices widely subjected vibration magnetic gradient coil propagates acoustic noise leads series clinical mechanical problems order address issue part noise cancellation study mri devices distributed piezo transducers bounded top surface funnel functional sensor actuator modules reduced order linear time invariant lti model piezolaminated structure state space representation estimated means predictive error minimization pem algorithm subspace identification method based trust region reflective technique reduced order model expanded introduction appropriate frequency dependent weighting functions address unmodeled dynamics augmented multiplicative modeling uncertainties system standard iteration algorithm output feedback control method used based nominal model subordinate uncertainty elements previous step finally proposed control system implemented experimentally real structure evaluate robust vibration attenuation performance closed loop system
clarification alcoholics anonymous participation generates change informs broader knowledge recovery processes offers improved understanding common factors underlie ostensibly religio spiritual program insights counter misunderstanding confusion impedes adoption freely available resources communities societies alcohol related disease burden high
increasing number applications three dimensional tumor spheroids vitro model drug discovery requires adaptation large scale screening formats every step drug screen including large scale image analysis currently ready use free image analysis software meet large scale format existing methods involve manually drawing length width imaged spheroids tedious time consuming process study presents high throughput image analysis software application spheroidsizer measures major minor axial length imaged tumor spheroids automatically accurately calculates volume individual tumor spheroid outputs results two different forms spreadsheets easy manipulations subsequent data analysis main advantage software powerful image analysis application adapted large numbers images provides high throughput computation quality control workflow estimated time process images min minimally configured laptop around min multi core performance workstation graphical user interface gui also designed easy quality control users manually override computer results key method used software adapted active contour algorithm also known snakes especially suitable images uneven illumination noisy background often plagues automated imaging processing high throughput screens complimentary manual initialize hand draw tools provide flexibility spheroidsizer dealing various types spheroids diverse quality images high throughput image analysis software remarkably reduces labor speeds analysis process implementing software beneficial tumor spheroids become routine vitro model drug screens industry academia
photodynamic therapy pdt treatment cancer tumour cells destroyed using reactive oxygen species produced photosensitizers following activation visible near infrared light successful pdt depends solubility targeting ability photosensitizers work synthesis porphyrin based water soluble nanoparticle conjugate containing targeting agent recognizes erbb receptor overexpressed surface particular cancer cells reported nanoparticle conjugates synthesized following two different protocols viz biphasic monophasic method aim determine method yielded optimal nanosystem potential pdt applications nanoparticles characterized using vis absorption fluorescence spectroscopies together transmission electron microscopy zeta potential measurements ability produce singlet oxygen following irradiation investigated following decay absorption singlet oxygen probe nanoparticles synthesized using monophasic method shown produce highest amount singlet oxygen functionalized anti erbb antibody target erbb receptors expressed surface human breast cancer cells water soluble antibody porphyrin nanoparticle conjugates shown elicit targeted pdt breast cancer cells elsevier inc rights reserved
genistein important chemopreventive agent atherosclerosis cancer however whether genistein effective treatment lung cancer underlying mechanism remains determined present study demonstrated genistein treatment lung cancer cells decreased viability dose time dependent manner induced apoptosis additionally cells exhibited significantly increased reactive oxygen species formation cytochrome leakage activated caspase cell lymphoma associated protein apoptosis inducing factor expression levels involved mitochondrial apoptosis pathway furthermore phosphatidylinositol biphosphate kinase pik protein kinase akt hypoxia inducible factor alpha hif alpha nuclear factor kappa kappa cyclooxygenase cox signaling pathways significantly downregulated genistein treatment conclusion reduced proliferation increased apoptosis lung cancer cells associated inhibition pik akt hif alpha kappa cox signaling pathways implicates genistein potential chemotherapeutic agent treatment lung cancer
objectives cigarette smoking pregnancy important modifiable risk factor poor birth outcomes evaluated whether participation statewide incentive based smoking cessation program pregnant women baby tobacco free bmtf program associated improved birth outcomes methods linked program birth certificate data pregnant smokers participated bmtf program pregnant smokers eligible enroll program analyzed bmtf program consisted prenatal smoking cessation counselling sessions postpartum follow visits breath carbon monoxide measurements monitor smoking status rewards diaper vouchers quitting smoking logistic regression models used examine associations program participation infant low birth weight preterm birth results participants completed prenatal smoking cessation sessions significantly lower rate low birth weight non participants adjustment multiple potential confounders odds ratios low birth weight confidence interval participants completing sessions confidence interval participants quit smoking compared non participants although statistically significant protective effect also suggested preterm birth conclusions found first time successful participation bmtf program unique incentive based smoking cessation program pregnant women implemented community settings associated significantly reduced odds low birth weight infant
paper present novel method based single phase active power filter apf series arc faults detection electrical installation apf reference current used starting point method tested large variety loads resistors vacuum cleaner rotary drill dimmer power supplies firstly proposed method validated simulation level using matlab software experimentally using hardware loop hil approach fpga altera stratix iii prototyping board results obtained work show series arc faults successfully detected apf updating digital control arc fault detection functionality instead designing beginning arc fault detection specific device elsevier rights reserved
addition role vision light exerts strong effects behavior powerful role modulation mood well established yet remains poorly understood much research focused effects light circadian rhythms subsequent interaction alertness depression recent discovery third photoreceptor melanopsin expressed subset retinal ganglion cells allows major improvement understanding photic information processed light affects behavior two ways either indirectly circadian timing system directly mechanisms independent circadian system latter effects barely studied regard mood recent investigations direct effects light sleep alertness suggest additional pathways light could influence mood based recent findings suggest light via melanopsin may exert antidepressant effect modulation homeostatic process sleep research needed understand mechanisms interplay contribute photic regulation mood research could improve therapeutic management affective disorders influence management societal lighting conditions published elsevier ltd
cancer classification based site origin significant research issue prediction treatment cancer paper addressing problem cancer classification homo sapiens genes composed amino acid chain cancer gene network realized equivalent electrical circuits based hydrophilic hydrophobic property amino acid classifier modeled determine cancer origin phase value peak gain value shape nyquist curve network model investigated characterize different types cancer gene origins model achieves classification accuracy proves sensitive simple since shows better performance compare existing nucleotide based method proposed classifier successfully predicts site origin cancer gene samples
protection volatile memory data issue crucial importance since authentication credentials cryptographic keys remain volatile memory reason volatile memory become prime target memory scrapers specifically target volatile memory order steal sensitive information credit card numbers paper investigates security measures protect sensitive information volatile memory disclosure attacks experimental analysis performed investigate whether operating systems windows linux perform data zeroization volatile memory results show windows kernel zeroize data process termination linux kernel next examine functions software techniques programming language used developers modify process runtime contents allocated blocks volatile memory identified windows operating system provide specific function named securezeromemory reliably zeroize data finally driven fact malware scrapers primarily target web browsers examine whether feasible extract authentication credentials volatile memory allocated web browsers presented results show cases successfully recover user authentication credentials web browsers except user closed tab used access website
paper presents design order butterworth low pass filter lpf wimax receivers cmos process due robustness process parameter tolerances passive ladder filter emulated using signal flow graph sfg method building block lpf highly linear operational transconductance amplifier ota based bias offset cross coupled differential pairs designed characterized ota property transconductance linearly controlled voltage bias corner frequency filter externally tuned achieve wimax specifications bandwidth layout simulations lpf achieved bandwidth mhz bias supply peak khz input dbc addition source follower output filter attained good output matching total power dissipation
discrete cosine transform dct discrete sine transform dst members sinusoidal family unitary transforms generalized signal flow graph dct dst type dct dst computation inverses dct iii dst iii described based fast recursive numerically stable hou algorithm generalized signal flow graph represents unified approach fast dct dst dct iii dst iii computation suitable implementation universal vlsi chip
purpose review galactose alpha galactose alpha gal carbohydrate allergen several unique characteristics article discuss recent advances understanding alpha gal syndrome highlight data supporting role ticks pathogenesis speculate immune mechanisms lead sensitization recent findings first described target ige individuals suffering immediate hypersensitivity reactions novel anti egf monoclonal antibody cetuximab clear gal sensitization associated mammalian meat allergy well reactions mammalian products unlike traditional ige mediated food allergies reactions gal often manifest several hours following exposure although factors influence presentation multiple pieces evidence including recent work mouse model point fact sensitization mediated exposure certain hard ticks increasingly aware globally widespread impact summary oligosaccharide gal represents novel allergen several unusual clinical features recognized multiple continents clinical presentation quite variable moreover efforts delineate mechanisms leading gal sensitization may ramifications broader understanding type immunity
aimone way assess foetal health smokers ask mothers count perceived movements unreliable method hiding differences prenatal development aim pilot study assess subtle foetal movements ultrasound scans establish whether differ foetuses mothers smoked nonsmoking mothers methodsthis longitudinal pilot study recruited twenty mothers nonsmoking smoking scanned four times weeks gestation ultrasound scans two types fine grained movements coded offline analysed using poisson log linear mixed model resultsfoetuses smoking mothers showed significantly higher rate mouth movements compared foetuses nonsmoking mothers controlling maternal stress depression pregnancy progressed differences smoking nonsmoking groups widened differences two groups rate foetal facial self touch remained constant pregnancy progressed borderline significant conclusionrates foetal mouth movement facial self touch differ significantly smokers nonsmokers larger study needed confirm results investigate specific effects including interaction maternal stress smoking additionally feasibility technique clinical practice assessed
alterations inhibitory gaba neurons including deficiencies gaba synthesizing enzyme gad prefrontal cortex schizophrenia pronounced subpopulations neurons contain calcium binding protein parvalbumin neuropeptide somatostatin presence similar illness related deficits transcription factor lhx regulates prenatal development parvalbumin somatostatin neurons suggests cortical gaba neuron dysfunction may related disturbances utero since chemokine receptors cxcr cxcr guide migration cortical parvalbumin somatostatin neurons birthplace medial ganglionic eminence final destination neocortex sought determine whether altered cxcr cxcr mrna levels associated disturbances gaba related markers schizophrenia quantitative pcr used quantify cxcr cxcr mrna levels prefrontal cortex schizophrenia healthy comparison subjects previously characterized markers parvalbumin somatostatin neurons antipsychotic exposed monkeys found elevated mrna levels cxcr cxcr schizophrenia subjects antipsychotic exposed monkeys cxcr mrna levels inversely correlated mrna levels gad parvalbumin somatostatin lhx schizophrenia healthy subjects findings suggest higher mrna levels cxcr possibly cxcr may represent compensatory mechanism sustain migration correct positioning cortical parvalbumin somatostatin neurons face insults disrupt prenatal development cortical gaba neurons schizophrenia elsevier rights reserved
study analyzes relationship psychological physical variables sports injuries total athletes different sports participated study variables related biomedical psychological sports injuries collected analysis data performed bayesian networks results suggest high probability self efficacy produce statistical dependence high likelihood sports injuries variable receives previous influences biomedical variables bmi psychological variables stress also consequential variables injury coping strategies locus control
objective investigate influence infectious complications outcome current standard preoperative chemotherapy followed surgery clinical stage iii esophageal cancer background impact postoperative infectious complications survival transthoracic esophagectomy remains controversial methods data randomized controlled trial jcog used infectious complications classified three groups pneumonia anastomotic leakage others univariate multivariate analyses using cox proportional hazard model performed results among analyzed patients incidence pneumonia leakage overall infectious complication overall survival patients infectious complication shorter patients without infectious complication hazard ratio confidence interval progression free survival pfs also tended shorter patients infectious complication patients pneumonia shorter patients without pneumonia pfs also tended shorter patients pneumonia patients anastomotic leakage nearly identical patients without leakage pfs showed tendency multivariate analysis revealed pneumonia tended compromise pfs conclusions results indicate postoperative infectious complications may worsen patient prognosis esophagectomy performing esophagectomy without postoperative complications especially pneumonia may beneficial improving survival outcomes
paper describes algorithm computing distribution conditional forecasts projections set variables interest future paths variables dynamic systems algorithm based kalman filtering methods computationally viable large models cast linear state space representation build large vector autoregressions vars large dynamic factor model dfm quarterly data set euro area macroeconomic financial indicators two approaches deliver similar forecasts scenario assessments addition conditional forecasts shed light stability dynamic relationships euro area recent episodes financial turmoil indicate small number sources drive bulk fluctuations euro area economy international institute forecasters published elsevier rights reserved
water pollution organic compounds one major challenges faced industries use dyeing processes thus methods developed degrading dyes wastewaters including heterogeneous photocatalysis semiconductor oxides however oxides limited photocatalytic activity due fast recombination photogenerated electron hole pairs aim study use carbon nanotube cnt tio zno oxide junction modified sol gel method promote degradation organic dye photocatalytic activity nanocomposites tio zno cnt nanocomposites studied ray diffraction xrd transmission electron microscope tem scanning electron microscope sem photocatalytic decomposition organic dyes results photocatalysis show efficiency samples removal dye
present field programmable analog array designed accurate low power mixed signal computation cmos reconfigurable analog incorporates digital enhancements increase compatibility embedded mixed signal systems chip contains computational analog blocks cabs house variety processing elements general cabs hundreds common analog primitives computation digital analog converter dac cabs compilable dac capabilities vector matrix multiplier cabs low power parallel processing floating gate routing matrix connects analog elements one another within individual cabs cabs facilitate digital interfacing dynamic reconfigurability included novel network volatile switches based digital shift select registers control analog switches dynamically controlled switches span rows columns internal routing allowing run time system modification scanning digital registers also double chip memory introduce new hybrid floating gate switch matrix includes switches eliminate previously observed mismatch issues provide highly precise computation highlight potential digitally enhanced analog processor demonstrate dynamically reconfigurable image transformer arbitrary waveform generator mixed signal fir filter
effects changes mandated child maltreatment reporting laws systematically evaluated better understand effects changes objectives present study assess relationships report rates state universal clergy reporting laws compare changes total confirmed maltreatment type report rates changes reporting laws examine whether relationship report rates nature mandated reporting law change used county level data national child abuse neglect data system years evaluate changes reporting rates total reports confirmed reports confirmed maltreatment types controlling concurrent changes child community variables found trends increased total confirmed reports similar counties universal clergy reporting requirements significantly contributed report rates even controlling child community factors universal reporting associated higher report rates physical sexual abuse clergy reporting requirements associated sexual abuse medical neglect psychological maltreatment confirmed reports however counties states changed clergy reporting laws higher increases total reports fewer confirmed physical sexual abuse neglect psychological maltreatment reports pronounced changes noted state made pronounced changes clergy reporting laws policymakers consider whether changing requirements mandated reporting meaningfully improves child maltreatment identification elsevier ltd rights reserved
cloud storage system provides facilitative file storage sharing services distributed clients address integrity controllable outsourcing origin auditing concerns outsourced files propose identity based data outsourcing ibdo scheme equipped desirable features advantageous existing proposals securing outsourced data first ibdo scheme allows user authorize dedicated proxies upload data cloud storage server behalf company may authorize employees upload files company cloud account controlled way proxies identified authorized recognizable identities eliminates complicated certificate management usual secure distributed computing systems second ibdo scheme facilitates comprehensive auditing scheme permits regular integrity auditing existing schemes securing outsourced data also allows audit information data origin type consistence outsourced files security analysis experimental evaluation indicate ibdo scheme provides strong security desirable efficiency
research conducted understand extend rothbart park innovative study trait attribution participants estimated baserate frequency correspondent behaviors behavioral expectations trait stereotypes frequency correspondent behavior appears determine evidence needed confirm disconfirm traits observed rothbart park shaping behavior expected persons trait baserate correspondent behavior high generally expected everyone less likely impact trait attributions contrast correspondent behavior uncommon expected primarily persons trait weighted heavily inference process findings help explain traits hard acquire easy lose positive trait attributions harder acquire easier lose negative trait attributions
commensal skin microbiota plays important role influencing immune response skin acting barrier colonisation potentially pathogenic microorganisms overgrowth opportunistic pathogens staphylococcus epidermidis key constituent normal microbiota human skin balances inflammatory response skin injury produces antimicrobial molecules selectively inhibit skin pathogens describe lactobacillus brevis dsm identified among hundreds lactobacillus strains exhibit anti inflammatory effect human keratinocytes vitro specific stimulatory impact growth epidermidis aqueous cell free extract brevis dsm used ointment formulation tested randomized placebo controlled double blinded human pilot study healthy volunteers diagnosed dry skin treated four weeks study data shows brevis dsm extract induces colonisation skin protective commensal microorganisms judged selective bacterial cultivation surface associated skin microorganism lower leg furthermore week administration brevis dsm extract significantly improved transepidermal water loss value tewl reduced xerosis cutis symptoms stinging data shows daily application brevis dsm extract topical product significantly improves microbial skin microbiota promoting growth species possess beneficial regulatory protective properties epidermidis restoring natural skin microbiota leads significantly improved skin barrier function transepidermal water loss decrease xeroderma xerosis cutis symptoms measured dry skin area severity index dasi propose improving stabilizing natural skin microbiota specifically stimulating growth epidermidis important novel concept manage skin diseases associated microbiota dysbiosis
present study examined role cumulative childhood maltreatment experiences several health related outcomes adulthood including symptoms psychological distress well perceived social support hardiness sample comprised adult survivors sexual abuse women mean age first abusive incident years one way anovas revealed statistically significant dose response relation cumulative childhood maltreatment scores self reported symptoms posttraumatic stress ptss anxiety depression eating disorders dissociation insomnia nightmare related distress physical pain emotional pain relational problems self harm behaviors well measure symptom complexity cumulative childhood maltreatment also associated lower levels work functioning inverse dose response relation found perceived social support hardiness using bonferroni corrected alpha level cumulative childhood maltreatment remained significantly associated outcome measures exception eating disorder symptoms controlling abuse related independent variables hierarchical regression analyses results add previous literature showing dose response relation cumulative childhood adversities adult symptom outcomes could also identified sample characterized high exposure adversities lends support notion put forth previous authors cumulative childhood adversities seem related severity adult health outcomes rule governed way elsevier ltd rights reserved
integration cchp systems large buildings provides considerable advantages far economy energy consumption environment related issues concerned paper integration hybrid cchp system commercial building studied hybrid cchp system consists renewable non renewable chp component photovoltaic thermal panels internal combustion engine ice three objective functions considered based cost saving energy saving emission reduction goals determined annual operating cost ratio aocr primary energy saving ratio pesr carbon emission reduction ratio cerr considering objective function optimization applied three different approaches single objective optimization problem find best size system components using analytic hierarchy process ahp one used multi criteria decision making mcdm procedures profitable answer determined three answers achieved optimization process results showed good performance system pesr optimization selected best system size values achieved aocr pesr cerr respectively elsevier rights reserved
modern operating systems linux capable executing multiple parallel applications concurrently many core platforms different applications may different characteristics regard exercise computation memory resources platforms paper aims investigate impact differences overall energy consumption performance trade offs analyze tradeoffs three parsec benchmark applications chosen different characteristics memory intensive cpu intensive mixture applications concurrently executed various combinations experiments also help establish optimized run time controls terms dynamic voltage frequency scaling dvfs thread core allocations run time controls based state space models derived linear regression using feedback hardware performance counters using benchmark applications demonstrate effectiveness proposed method shows improvement power normalized performance expressed ratio instructions per second ips power consumption watt
gastroesophageal reflux disease gerd dyspepsia highly prevalent general population significant symptom overlap interaction remains poorly understood examine whether gerd overlapping dyspepsia would impact clinical psychological features compared gerd alone performed cross sectional study gerd cohort previously recruited population based gerd survey compared clinical psychological factors patients without dyspeptic symptoms epigastric pain burning participants evaluated reflux disease questionnaire score pittsburgh sleep quality index score taiwanese depression questionnaire score state trait anxiety inventory score endoscopic findings classified according los angeles classification among gerd population subjects overlapping epigastric pain burning gerd symptoms gerd alone gerd subjects severe gerd symptoms often associated irritable bowel syndrome ibs compared subjects gerd alone addition gerd subjects lower quality sleep higher depression lower blood pressure higher serum total cholesterol levels gerd alone gerd subjects characterized worsening clinical symptoms well higher psychosocial ibs metabolic comorbidities less erosive esophagitis results indicate clinical awareness overlapping condition would help optimize management gerd clinical practice
study uses time diary data dual earner couples belgium denmark spain united kingdom analyze educational inequalities parental care time different national contexts mothers education significantly associated parenting involvement spain united kingdom spain differences largely explained inequalities mothers time monetary resources united kingdom less educated mothers disproportionally work short parttime jobs fathers education associated parenting time denmark particularly spain wife resources substantially drive associations weekends educational gradient parental care time applies spain united kingdom two countries particularly large inequalities parents opportunities engage parenting study shows country variations educational inequalities parenting suggesting socioeconomic resources especially mothers shape important variations parenting involvement published elsevier inc
drug resistance tuberculosis predominantly mono resistance multi drug resistance extensively drug resistance totally drug resistance emerged major problem chemotherapy tuberculosis failures first second line anti tuberculosis drugs treatment leads emergence resistant mycobacterium tuberculosis genes reported principal targets resistance apart primary targets many explanations proposed drug resistance still resistance mechanisms unknown proteins involved biological processes potentially explored unknown mechanism drug resistance attractive targets diagnostics future therapeutics drug resistance last decade panel studies expression proteomics drug resistant tuberculosis isolates reported differential expression uncharacterized proteins suggested might involved resistance emphasize detailed bioinformatics analysis like molecular docking pupylation proteinsproteins interaction uncharacterized hypothetical proteins might predict interactive partners proteins involved various pathways tuberculosis system biology might give clue novel mechanism drug resistance future drug targets future uncharacterized targets might open new resistance mechanism used potential drug targets drug resistant tuberculosis
paper presents several conceptual approaches improving user engagement happiness mass transport systems effectively integrating principles ambient aesthetic intelligence introduce themed passenger carriages constructed spaces overarching topic narrative designed make commuting meaningful immersive experience examine challenges commuters existing solutions following develop scenarios related fields recreation culture education business entertainment increasing interest policy makers concept happiness socioeconomic measure national wellbeing identify generic approaches future research authors published elsevier
background study examined whether acutely amdd remitted depressed patients rmdd show deficits two aspects social cognition facial emotion recognition fer reasoning using ecologically valid material furthermore examined whether reduced facial mimicry mediates association depressive symptoms fer whether fer deficits reasoning deficits associated method amdd rmdd healthy controls fer assessed using stimuli amsterdam dynamic facial expression set reasoning movie assessment social cognition furthermore activity zygomaticus major corrugator supercilii recorded results amdd recognized happy faces less accurately less confident recognizing happiness anger found difficult recognize happiness anger fear rmdd less confident recognizing anger found difficult recognize happiness anger fear reduced mimicry explain fer deficits amdd rmdd showed impaired reasoning limitations stimulus material comparably easy decode therefore possible fer deficits amdd rmdd patients pronounced demonstrated study conclusions amdd show deficits fer reasoning whereas rmdd show mild impairments recognition emotional expressions must processes besides mimicry serve accurate recognition emotional facial expressions
concept wave filtering followed derivation high order filter topologies employing current feedback operational amplifiers active blocks purpose wave equivalent appropriate passive element chosen elementary building block introduced wave equivalents passive elements derived performing appropriate manipulations configuration wave equivalent elementary building block attractive characteristic offered derived filter topologies modularity structures validity proposed method verified experimental results case order lowpass filter
multiferroic xalxmno prepared using standard solid state reaction dielectric properties samples investigated wide ranges frequencies temperatures means complex impedance spectroscopy isovalent substitution distinctly influences structural dielectric properties parent tbmno conductivity data undoped doped samples fit well jonscher law sigma omega sigma omega resulting fitting parameters indicated hopping process occured neighboring sites conductivity regime followed arrhenius relation activation energies undoped doped samples respectively turn conductivity well described small polaron hopping model energies undoped doped samples respectively real part dielectric permittivity epsilon increased increasing temperature lowering frequency value epsilon also increased doping occurrence non debye type relaxation verified studied samples relaxation dynamics charge carriers samples examined within electric modulus formalism allowed determining probable relaxation time respective activation energy dielectric relaxation temperature range activation energy dielectric relaxation calculated undoped doped samples respectively imperfect overlapping reduced plots modulus curves single master curve particularly higher frequencies temperatures concentrations considered suggests behavior dynamic processes slightly temperature content dependent finally impedance spectra characterized appearance semicircle arcs well modeled terms equivalent electrical circuits elsevier ltd techna group rights reserved
paper presents educational software tool called wtcontrolgui whose main purpose show applicability performance different decoupling control strategies wind turbines nowadays wind turbines important field control engineering therefore educational point view tool also aims improve learning multivariable control concepts applied field addition wtcontrolgui allows testing controlling lab scale system emulates dynamic response large scale wind turbine designed graphical user interface essentially allows simulation experimental testing decoupling networks multivariable methodologies robust decentralized control strategies tool available master degree students control engineering survey performed evaluate effectiveness proposed tool used educational related tasks wiley periodicals inc
prevalence associated factors erectile dysfunction human immunodeficiency virus hiv infected men remain controversial authors evaluated clinical emotional variables group hiv infected men cross sectional month observational study assessed using international index erectile function emotional status using hospital anxiety depression questionnaire median age interquartile range years time since hiv diagnosis years taking antiretroviral treatment hiv rna viral load copies prevalence mild mild moderate moderate severe medications used men univariate analysis variables associated degrees older age longer time since hiv diagnosis higher scores taking efavirenz taking etravirine taking ritonavir hiv hepatitis virus coinfection taking protease inhibitor containing regimen mild moderate moderate severe variables significant lower nadir cell count lower social support taking atazanavir concomitant conditions concomitant treatments variables remained significant multivariate analyses considering degrees excluding mild following older age higher scores total summary affected half cohort well controlled hiv infected men age emotional status seemed play fundamental role presence
fuel cell cehicles fcvs clear societal environmental benefits help mitigate issues climate change urban air pollution oil dependence order fcvs biggest impact issues need employed large numbers first though need adopted consumers acceptance depends positive consumer attitudes towards vehicles currently limited understanding within literature consumers perceive fcvs likelihood adoption consumers would despite significant governmental organisational investments technology therefore study assesses consumer attitudes towards fcvs united kingdom persons drove hyundai fcv low carbon vehicle event september took part study results show present fcvs perceived mostly similar incumbent internal combustion engine vehicles admirable technical achievement however order consumers adopt fcvs need perceived distinctive benefits two significant barriers adoption fcvs observed sample high costs lack refuelling infrastructure paper goes make suggestions beneficial attributes vehicles promoted consumers also makes suggestions barriers overcame fcvs adopted consumers copyright authors published elsevier ltd behalf hydrogen energy publications llc
study aimed determine changes mould ochratoxin ota occurrence sultanas three different conventional drying conditions five different vineyards chosen three different treatments applied grapes drying end drying process total mould black aspergilli populations samples varied log colony forming units cfu log cfug respectively significant increases occurred mould loads depending extending drying period however independent vineyard location samples treated cold dipping solution showed lowest fungal loads results indicate dipping solution treatment effective drying method minimise fungal infection grapes expected results could achieved drying grapes artificially contaminated ochratoxigenic aspergillus carbonarius spores seventy one isolates obtained drying aspergillus spp remaining belonged genera penicillium trichoderma cladosporium grape juice based agar medium used determine realistic ota production capacities isolated mould strains highest ota production capacities ngg grape juice agar five niger isolates ota present sample drying period however ota detected two samples gkg end drying process limit detection lod limit quantitation loq method used detecting ota samples gkg respectively
kind sustainable development mode energy efficient building green design ideal way new rural development china future also direction world development taking green energy saving design practice application new rural construction illustration paper turns energy efficient building green design broad prospects typical meanings new rural construction wang demonstration village new rural construction hebei province rainwater harvesting waste water treatment gray water utilization natural landscape water fall building energy conservation biogas utilization etc wang everything without exception annotate significance green design green construction
image intensities low backscattering areas synthetic aperture radar sar images often seriously contaminated system noise floor azimuthal ambiguity signal adjacent high backscattering areas hence image intensity low backscattering areas correctly reflect backscattering intensity causes confusion subsequent image processing interpretation paper method proposed estimate normalized radar cross section nrcs low backscattering area utilizing differences noise azimuthal ambiguity signal doppler frequency domain single look sar images aim eliminate effect system noise azimuthal ambiguity analysis shows spaceborne sar noise equivalent sigma zero nesz single look pixel nrcs estimation precision method reach resolution three examples given validate advantages method estimating low nrcs filtering azimuthal ambiguity
titan moon substantial atmosphere thick atmosphere besides earth site extraordinarily complex atmospheric chemistry far surpasses solar system atmosphere solar system body stable liquid currently surface connection titan surface atmosphere also unique solar system atmospheric chemistry produces materials deposited surface subsequently altered surface atmosphere interactions aeolian fluvial processes resulting formation extensive dune fields expansive lakes seas titan atmosphere favorable organic haze formation combined presence oxygen bearing molecules indicates titan atmosphere may produce molecules prebiotic interest combination organics liquid form water subsurface ocean methane ethane surface lakes seas means titan may ideal place solar system test ideas habitability prebiotic chemistry ubiquity diversity life universe cassini huygens mission saturn system provided wealth new information allowing study titan complex system review current understanding titan atmosphere climate forged powerful combination earth based observations remote sensing situ spacecraft measurements laboratory experiments models conclude remaining unanswered questions incredible era exploration cassini huygens comes end plain language summary titan largest moon saturn unique solar system moon dense atmosphere thick nitrogen atmosphere besides earth atmosphere complicated chemistry started sunlight forms molecules made carbon hydrogen nitrogen oxygen sometimes called organic molecules molecules end surface moved wind rain form dunes lakes seas world besides earth lakes seas presently surface although made liquid methane ethane instead water conditions titan atmosphere ideal creation smog like particles called haze may molecules important origin life combination liquid organics means titan may best place solar system test ideas life begins common universe cassini huygens mission saturn system provided wealth new information allowing study titan system review current understanding titan atmosphere climate forged powerful combination earth based observations measurements spacecraft laboratory experiments computer models conclude remaining unanswered questions incredible era exploration cassini huygens comes end
tnf alpha inhibitors infliximab etanercept adalimumab used treatment psoriasis vulgaris psoriatic arthritis along inhibitors proinflammatory cytokines interleukin paper presents results research use biological drugs tumor necrosis factor blockers tnf alpha namely inhibitors ustekinumab cell inhibitors alefacept efalizumab cell inhibitors rituximab anti agents secukinumab ixekizumab brodalumab ilp inhibitors guselkumab tildrakizumab paper presents analysis mechanism action recommended doses methods therapy taking account adverse events associated use anti cytokine therapy use biological drugs discussed based review current literature
asthma common chronic disease affects large portion population many nations driven fast development sensor mobile communication technology smart asthma management system become available continuously monitor key health indicators asthma patients data provides opportunities healthcare practitioners examine patients clinic site also outside clinic site daily life paper taking advantage data availability propose correlated gamma based hidden markov model framework reveal highlight useful information rescue inhaler usage profiles individual patients practitioners proposed method provide diagnostic information asthma control status individual patients help practitioners make informed therapeutic decisions accordingly proposed method validated numerical study case study based real world data copyright john wiley sons ltd
peristaltic motion non newtonian carreau fluid analyzed curved channel long wavelength low reynolds number assumptions simulation digestive transport flow regime shown governed dimensionless fourth order nonlinear ordinary differential equation subject slip wall boundary conditions well tested finite difference method based iterative scheme employed solution boundary value problem important phenomena pumping trapping associated peristaltic motion investigated various values rheological parameters carreau fluid curvature channel increase weissenberg number found generate small eddy vicinity lower wall channel enhanced increase weissenberg number shear thinning bio fluids power law rheological index greater weissenberg number displaces maximum velocity toward upper wall shear thickening bio fluids velocity amplitude enhanced markedly increasing weissenberg number
recent evidence suggests different patterns prenatal survival causing different levels intrauterine crowding occurring prolific sows bearing litters piglets born resulting marked differences average litter birth weight early intrauterine crowding embryos known negative effects prenatal development objective study compare litter characteristics well histomorphometrical molecular traits myofibers selected offspring born litters high low average birth weight selected newborn littermates either two females representing intermediate low birth weight litters two females representing intermediate high birth weight litters piglets sacrificed day birth longissimus semitendinosus muscles collected average birth weight selected piglets differed whereas piglets similar birth weaning offspring grew faster associated greater body weight loss compared sows lactation feed intake differ offspring brain proportion birth weight brain ratio greater similar progenies expressed per dark portion piglets fewer primary similar secondary myofiber numbers compared progeny nevertheless due larger total myofiber number greater piglets myofiber characteristics similar across birth weight classes except greater secondary primary myofiber ratio offspring expression myoblast differentiation factor greater offspring birth weight class differences occurred myosin heavy chain isoform distribution conclusion female progenies falling mid weight range litters heavier littermates carried negative phenotypic traits normally associated intrauterine growth restriction greater brain ratio impaired myofiber hyperplasia elsevier rights reserved
convincing evidence many young people justice system contact child protection services victims childhood maltreatment increased risk subsequent youth justice involvement australia however longitudinal studies examined associations relatively less known area study examines overlap child protection youth justice involvement south australia determines substantiated maltreatment variations experiences type timing recurrence maltreatment relate criminal convictions youth results show although majority child protection involved youth become convicted offenders odds subsequent convictions significantly greater notifications substantiated maltreatment placed home care multivariate analyses revealed strongest predictors receiving conviction among maltreated youth male gender aboriginal torres strait islander ethnicity experiences physical abuse emotional abuse greater number substantiations recurrence experiencing maltreatment commenced childhood continued adolescence placement home care mechanisms maltreatment might linked behavior considered along directions future research area elsevier ltd rights reserved
throughout past decade numerous states passed legislation prohibit sale violent video games children usually conjunction argument exposure violent media increases violent behavior however link video games violence yet fully understood study uses propensity score matching method adequately address underlying issue causality using sample grade students analyses test whether causal link playing violent video games violence non violent deviance substance use results indicate substantial decrease relationship video games outcomes matched sample used suggests strength evidence supporting relationship likely overestimated using methodologies elsevier ltd rights reserved
throughout short history software development characterized harmful disconnects important activities planning development implementation problem exacerbated episodic infrequent performance activities planning testing integration releases several emerging phenomena reflect attempts address problems example continuous integration practice emerged eliminate discontinuities development deployment similar vein recent emphasis devops recognizes integration software development operational deployment needs continuous one argue similar continuity required business strategy development bizdev term coin disconnects even problematic given need reliability resilience complex data intensive systems developed today identify number continuous activities together label continuous continuous star present part overall roadmap continuous software engineering argue continuous necessarily rapid software engineering delivery pipeline conclude paper research agenda elsevier inc rights reserved
develop new analytical model alfven wing generated interaction planetary moon ionosphere magnetospheric environment preceding analytical approaches assumed obstacle height integrated ionospheric conductivities spatially constant model presented take account continuous conductance profile follows power law electric potential interaction region determining electromagnetic fields alfven wing calculated euler type differential equation way model allows include realistic representation suspension bridge like conductance profile expected moon ionosphere major drawback approach restriction interaction scenarios ionospheric pedersen conductance large compared hall conductance thus alfvenic perturbations approximately symmetric planet facing planet averted hemispheres moon model applied hemisphere coupling effect observed enceladus surface currents associated magnetic discontinuities arise north south asymmetry obstacle plasma flow show occurrence effect robust changes conductance profile enceladus plume derive upper limits strength magnetic field jumps generated hemisphere coupling effect reported detections hemisphere coupling currents enceladus observed magnetic field jumps clearly weaker proposed limits findings also relevant future situ studies putative plumes jovian moon europa
aim prospective study designed evaluate tolerability efficacy weekly sox oxaliplatin cetaximab first line chemotherapy wild type ras metastatic colorectal cancer patients methods studied patients previously untreated unresectable advanced recurrent colorectal cancer treated hospital october march performance status cetuximab combined oxaliplatin sox cetuximab given orally dose calculated according body surface area twice daily meals weeks followed week rest course oxaliplatin given days course cetuximab administered days course followed every weeks thereafter results study group comprised patients mean age range years male female ratio patients patients median number administered courses range treatment response complete response partial response response rate patients minimum number treatment courses indicating early response liver resection performed patients incidence adverse events grade including skin disorder dry skin cutaneous pruritus contusion pamnychia well peripheral sensory neuropathy grade events skin disorders peripheral sensory neuropathy mostly observed patients events controllable preventive skin care withdrawal close reduction respectively death due adverse events observed adverse events require withdrawal regimen conclusion based patients studied combined therapy sox cetuximab free serious adverse events could safely administered reducing dose temporarily suspending treatment required regimens seem promising conversion therapy patients good outcomes early response
research aims develop indicators assessing green interior design new residential buildings china grounded socio technical systems approach research carried critical literature review two focus group studies results show boundaries green interior design identified respect three dimensions namely performance methodology stakeholders socio technical systems approach argues recognition interdependence systems elements feature embeddedness interdependence systems elements exists within three dimensions across also found socio technical systems green interior design embedded social regulatory geographic context taking interior design residential buildings empirical setting study contributes literature green building assessment presenting socio technical systems approach
hiv infected individuals risk psychological distress including depression sadness suicidality purpose qualitative descriptive study examine hiv infected african american women experiences psychological distress use coping strategies data collected person one one interviews conceptual saturation reached data analyzed using inductive content analysis four themes found psychoemotional suffering contextual factors negatively influence everydayness living hiv infection hiv related stigma perpetuates isolation loneliness creating safe implications nurses health care providers include holistic assessment include evaluation emotional mental state coping strategies integration spiritual practices plan care also important development evaluation individualized coping interventions address stigma psychological distress holistic modalities warranted copyright association nurses aids care
hereditary angioedema hae rare autosomal dominant disease commonly manifests episodes cutaneous submucosal angioedema intense abdominal pain condition usually presents due deficiency esterase inhibitor inh leads overproduction bradykinin causing abrupt increase vascular permeability less understood less common form disease presents normal inh levels symptoms angioedema may confused initially mast cell mediated angioedema allergic reactions may perplex physicians epinephrine antihistamine glucocorticoid therapies provide relief similarly abdominal attacks may lead unnecessary surgeries opiate dependence affected individuals risk life threatening episode laryngeal angioedema continues source fatalities due asphyxiation unfortunately diagnosis delayed average almost decade due misunderstanding symptoms general lack awareness disease physicians suspect hae however diagnostic methods reliable available laboratories include testing inh protein inh functional levels patients hae management consists acute treatment attack well possible short long term prophylaxis plasma derived inh ecallantide icatibant recombinant human inh new treatments shown safe effective treatment hae attacks current understanding hae greatly improved recent decades leading growing awareness new treatments improved management strategies better outcomes patients
research suggests relationship health urban populations availability green water spaces daily environment paper analyze potential intra urban relationships children health determinants outcomes natural areas berlin germany particular health indicators deficits viso motoric development children related environmental indicators natural area cover natural area per capita distance natural areas however indicators also correlated social determinants health methodological approach used study included bivariate multivariate analyses explore relations health inequalities social socio economic land use parameters results sub district level indicated correlation natural areas social health determinants displayed certain intra urban spatial pattern particular lower percentage natural area cover correlated deficits viso motoric development however results percentage natural area cover per capita natural area childhood overweight conclusive significant correlation found percentage natural area cover overweight significant negative correlation values found overweight per capita natural area identified particularly districts lower social conditions hand districts highest social conditions comparatively lowest levels complete measles immunization study may facilitate public health work identifying urban areas strengthening health resources actions prioritized also calls inclusion natural areas among social health indicators included intra urban health inequality tools
true dynamic characteristics dams namely natural frequencies damping ratios mode shapes important earthquake resistant design thus system identification based site measurements useful numerical analysis health monitoring well instrumented strong motion array arch dam southwestern china recorded seismic response data dynamic properties dam identified records top five strongest earthquake motions using power spectral density functions transfer functions arx model identified modal parameters different seismic events compared stability stiffness dam system nonuniformity input ground motion indicated linear finite element model dam nonlinear model considers contraction joints constructed calibrated reproduce frequencies determined system identification modal analysis highlights potential information dynamic characteristics dam comparison results system identification calibration shows use nonlinear model may reasonable simulating dynamic response ertan dam
aim study analyze energy consumption public transport lublin selected means transport solaris trollino trolleybus solaris trollino ursus electric bus currently lublin transportation fleet equipped electric drive due lack emission greenhouse gasses place exploitation quiet drive operation greater efficiency internal combustion engine well durability modem traction drives allow carry process regenerative braking recuperation energy trolley wires energy storage systems basis energy consumption analysis three means transportation equipped electric drive assume regenerative braking process significantly contributed limitation energy consumption
context software library reuse significantly increased productivity software developers reduced time market improved software quality reusability however growing number reusable software libraries code repositories finding adopting relevant software library becomes fastidious complex task developers objective paper propose novel approach called libfinder prevent missed reuse opportunities software maintenance evolution goal provide decision support developers easily find useful third party libraries implementation software systems method end used non dominated sorting genetic algorithm nsga multi objective search based algorithm find trade three objectives maximizing usage candidate library actual libraries used given system maximizing semantic similarity candidate library source code system minimizing number recommended libraries results evaluated approach different libraries maven central super repository used client systems obtained github super repository results show approach outperforms three existing search techniques state art approach based heuristic search succeeds recommending useful libraries accuracy score precision recall finding best trade three considered objectives furthermore evaluate usefulness approach practice empirical study two industrial java systems developers results show top recommended libraries rated original developers average conclusion study suggests library usage history collected different client systems library semantics content embodied library identifiers balanced together efficient library recommendation technique elsevier rights reserved
wave energy converters generally suffer low operating power factor due nature long wavelength water wave inductance electrical generator employed conversion process forced commutated series capacitor fcsc converter connected generator load circuit prevent power factor degradation paper describes effectiveness new fcsc control strategy developed operation low variable frequencies corresponding nature water waves simulation results show proposed symmetrical duty cycle control strategy capable maintaining almost unity power factor required frequency range
background allogeneic hematopoietic stem cell transplantation hsct potentially curative variety hematological malignancies graft host disease gvhd remains life threatening complication standard treatment high dose corticosteroids steroid refractory gvhd associated poor prognosis present second line treatment ill defined includes number agents novel insights pathophysiology acute gvhd agvhd highlight relevant role host inflammatory response governed several kinase families including janus kinases jak ruxolitinib jak inhibitor approved intermediate high risk myelofibrosis recently employed gvhd encouraging overall response rates clinical experience however remains limited case presentation year old male refractory anemia excess blast type underwent myeloablative allogeneic hsct hla matched unrelated donor conditioning busulfan cyclophosphamide gvhd prophylaxis consisted cyclosporine methotrexate thymoglobulin cells infused day patient developed overall grade agvhd biopsy proven stage gastrointestinal gvhd refractory corticosteroids patient conditions rapidly deteriorated became critical despite addition mycophenolate mofetil budesonide day ruxolitinib started day patient clinical conditions gradually improved complete resolution agvhd also confirmed histology day conclusions months hsct patient well continuous hematological complete remission without flare gvhd ruxolitinib discontinued day ruxolitinib feasible effective agvhd though large prospective clinical trials warranted
day cumulative irritation test widely used evaluating irritation potential topical skin care products test consists clinician assessment skin reaction patch sites classification system categorize test product irritation potential new classification system proposed enables control estimation error provides statistical confidence regard repeatability classification
study focuses examining behavioral component third person effect explores self perceptual gap concerning influence nuclear pollution news prediction different actions corrective protective promotional study analyzes data probability sample collected taiwan news nuclear pollution fukushima widely reported results showed discrepancy self perceptions significant predictor multiple behavioral intentions included seeking self protection taking iodide pills supporting corrective actions opposing building new nuclear power plants supporting government led promotional measures launching public educational campaigns nuclear safety results indicate behavioral component third person effect extends beyond realm willingness censor
background glucose variations common throughout sleep wakefulness people type diabetes mellitus tdm objective investigation characterize time varying coupling glucose unstructured physical activity period young adults tdm hypothesis coupling would differ sleep versus wakefulness would exhibit circadian variations method young adults tdm treated insulin pump participated study glucose variations monitored continuous glucose monitoring system activity assessed using activity monitoring band worn nondominant wrist simultaneous glucose physical activity data across continuous period used analysis wavelet coherence analysis employed quantify coupling physical activity glucose cosinor analysis used assess whether glucose activity coherence exhibited significant circadian variations results participants comprised adults aged years tdm coherence analysis demonstrated substantial coupling physical activity glucose variations wakefulness sleep rapid min fluctuations mean coherence higher sleep wakefulness rapid glucose variations consistently led changes activity sleep wake cosinor analysis revealed significant circadian modulation glucose activity coupling especially fluctuation periods conclusions unstructured physical activity glucose variations demonstrated strong time frequency dependent coupling period young adults tdm sleep wake differences circadian modulation evident relationship
modular multilevel converter mmc half bridge submodules sms promising technology high voltage direct current hvdc grids lacks fault clearance capability two main methods handle side short circuit fault one employ sms fault clearance capability power losses high converter blocked clearance employ hybrid hvdc breakers breaker capable interrupting fault current within technology cost effective especially meshed hvdc grids paper assembly hvdc breaker corresponding control strategy proposed overcome drawbacks assembly hvdc breaker consists active short circuit breaker ascb main mechanical disconnector main breaker accessory discharging switch ads side short circuit fault occurs ascb ads close immediately shunt fault current main breaker opens short delay isolate faulted line system mechanical disconnector opens disconnector open position ascb opens breaks current proposed breaker handle side fault competitively low cost operating speed fast enough model four terminal monopolar hvdc grid developed power systems computer aided design electromagnetic transients including simulation result proves validity feasibility proposed solution
background vitamin implicated important maintaining cognitive function old age results longitudinal studies examining association vitamin incident dementia cognitive impairment inconsistent objective investigated relation vitamin assessed different ways risk dementia design measured plasma hydroxyvitamin use high performance liquid chromatography mass spectrometry assessed dietary vitamin intake use dietary records created vitamin synthesis genetic risk score grs baseline cohort swedish men mean age maximum median follow men developed alzheimer disease men developed vascular dementia men developed cause dementia additional men declined cognitive function assessed use mini mental state examination adjusted hrs ors calculated use cox logistic regressions results mean plasma concentration nmol plasma dietary vitamin intake vitamin synthesis grs associated cognitive outcomes crude adjusted hrs ors similar continuous exposures adjusted cause dementia men plasma concentrations nmol adjusted cause dementia lowest compared highest tertiles vitamin intake adjusted continuous grs cause dementia conclusion cohort study show association baseline vitamin status long term risk dementia cognitive impairment period time
flutter stability long span suspensions bridges erection problematic final state characteristics flutter stability construction influenced many factors sequence deck erection paper numerical flutter stability analyses performed construction process zhongdu bridge yangtze river using commercial package ansys effect stiffness reduction stiffening girder structural damping initial wind attack angle sequence deck erection discussed detail found non symmetrical sequence deck erection confirmed aerodynamically favorable deck erection long span suspension bridges best erection sequence investigated design phase initial wind attack angle degrees advantageous aerodynamic stability initial wind attack angle degrees disadvantageous comparing initial wind attack angle degrees deck erection stiffness reduction stiffening girder slightly effect flutter wind speed suspension bridge erection structural damping great impact especially early erection stages
background carotid femoral pulse wave velocity pwv aortic pwv measured using mri mri pwv show good correlation significant consistent bias across studies aim current study evaluate whether differences pwv mri pwv accounted inaccuracies currently used distance measurements methods one hundred fourteen study participants recruited one groups type diabetes melltus tdm cardiovascular disease cvd tdm without cvd cvd without tdm control group participants underwent pwv cardiac mri whole body angiography mra study participants also underwent aortic pwv using mri pwvext performed using sphygmocor device atcor medical west ryde australia true intra arterial pathlength measured using mra used recalculate pwvext give pwvmra results distance measurements significantly lower mra external tape measure mean diff mri pwv significantly lower pwvext mri pwv pwvext pwv recalculated using inter arterial distance mra difference significantly reduced lost mri pwv pwvmra mean diff recalculation pwv increased correlation age pulse pressure conclusion differences pwv mri pwv predominantly entirely explained inaccuracies introduced use simple surface measurements represent convoluted arterial path carotid femoral arteries
building systems enable knowledge sharing decision support among clinicians across organizational geographical boundaries complex important task lies core idea telehealth practice centered awareness potential enhance usability cross boundary clinical decision support systems providing shared context work decision support across organizational geographical boundaries based awareness clinician work contexts practice related work activities including local workarounds non explicit rules improvisation strategies institutional agenda patients needs present multi method evaluation practice centered awareness features cadhealth cadhealth clinical decision support system enables clinicians construct awareness one another work activities contexts across geographical organizational boundaries based three categories work practice ontological stereotyped situated work practices evaluation results indicate incorporating practice centered awareness features telehealth systems results better work coordination across organizational geographical boundaries leads effective cross boundary clinical decision support enhances perceived usefulness adoption telehealth health applications elsevier ltd rights reserved
mentalizing theory mind tom ability recognize people think feel crucial component human social intelligence recently proposed tom decomposed automatic controlled neurocognitive components latter engage executive functions working memory inhibitory control task switching critical notion dual processes expected follow different developmental dynamics work provide novel experimental evidence notion report data gathered thirty thousand participants massive web poll peoples cognitive skills included tom executive functions show although maturation executive functions occurs synchrony around years age case different mentalizing competences either mature elementary tom constituents higher level tom addition show inter individual differences executive functions predict variability higher level tom skills onset adulthood onwards complete maturation executive functions taken together results indicate relative contribution tom controlled component significantly changes age particular implies lifespan people may rely upon distinct cognitive architectures reading others minds elsevier ltd rights reserved
background one strategies proven successful curbing rising rates childhood obesity involves targeting parents agents change prior studies focused messages communicate investigated communicated objective identify channels effective communicating parents overweight obese children understand whether use parenting information sources differs others community design setting study utilizes data longitudinal study australian children lsac families included weight height information available parents children three data collection points waves collected respectively analysis priori posteriori segmentation methods identified groups parents similar sources used obtain information parenting examined whether segments likely obese children results four segments identified differed information source use personal networks books official sources mixed approach segments official sources mixed approach segments likely obese children used doctors government community organizations friends obtain information parenting segments also less educated lower employment conclusions messages likely reach families obese children communicated doctors government publications community organizations messages targeting social groupings parents leverage power advice friends another valuable information source group
complexity hydrogeological setup coastal areas calls adoption scientific groundwater management techniques excessive withdrawal groundwater coastal zones lead depression water table associated hazards putting well use rendering abstraction uneconomic increased lift sustained regional groundwater drawdown sea level runs risk saline water intrusion even confined coastal aquifers uncontrolled groundwater development may lead reversal freshwater gradient thereby resulting saline water ingress coastal aquifers however several established methodologies control minimise problems associated groundwater extraction followed saline water intrusion study developed convenient easily implementable analytical model coastal groundwater management aimed control saltwater intrusion technique includes withdrawal coastal freshwater means qanat well structures associated artificial recharge rainwater harvesting aided percolation ponds recharge wells proposed methodology suitable specifically highly urbanised coastal areas significant annual precipitation good hydraulic conductivity aquifer low depth fresh groundwater case study model applied coastal zone purba medinipur district west bengal india adequate quantifications efficiency methodology incorporated relevant conclusions drawn
software reliability one important software quality indicators concerned probability software execute without unintended behavior given environment previous research developed reliability prediction system reps methodology predict reliability safety critical software used nuclear industry reps methodology relates software engineering measures software reliability using various models found reps using extended finite state machine efsm models fault data collected various software engineering measures possess satisfying prediction capability research efsm based reps methodology improved implemented tool called automated reliability prediction system arps features arps tool introduced simple case study experiment using human subjects also conducted evaluate usability tool results demonstrate arps tool indeed help analyst apply efsm based reps methodology less number errors lower error criticality
background paper describes development new airway device improve speed safety endotracheal intubation anaesthesia critical care case need design specification fabrication steerable bougie mechanism discussed aims identify need novel steerable bougie whilst considering technology readiness levels associated medical device design analyse produce suitable mechanisms utilising smart materials increase device functionality aiding successful patient intubation procedures methods work describes total design activity contributes successful development medical devices case need smart material actuation mechanisms research focuses identifying suitable control mechanism allow steerable tip integrated bougie control device attached laryngoscope results data collected user group survey supported development novel bougie better shape retention variable rigidity within tip integrated steerable function analysis several mechanisms artificial muscles smart materials identified cost effective steerable mechanism incorporated bougie conclusion users defined need improved bougie controlling smart materials mechanisms within predefined dimensions identified strengths weaknesses associated steerable functions performance selected mechanism incorporation requires high level control accurately steer device within human airway
wild pink salmon oncorhynchus gorbuscha great economic importance meat quality higher breeding salmons however consumption wild pink salmons public health concern due high risk infection third stage nematode larvae family anisakidae anisakis pseudoterranova genera causative agents anisakidosis allergies even fatal aims present work investigate infection prevalence species identity anisakidae larvae fillets north pacific wild pink salmons total samples frozen fillets collected examined artificial digestion method detected fillets recovered identified anisakis type pseudoterranova morphological examination one infected fish identified anisakis simplex sensu stricto pseudoterranova decipiens pcr rflp despite risk acquiring human anisakidosis efficiently prevented fish fillet freezing findings highlight high prevalence anisakidae larvae frozen fillets pink salmon may source allergic reactions sensitized persons increased interest consumers pink salmon may pose considerable food safety problems merits systematically investigated elsevier ltd rights reserved
janus kinase jak jak inhibitor ruxolitinib currently therapy indicated intermediate high risk myelofibrosis results clinical trials experience clinical practice shown ruxolitinib reduces myelofibrosis related splenomegaly symptom burden improves quality life measures addition ruxolitinib associated survival advantage compared placebo conventional therapy controlled trials however owing myelosuppressive effects jak inhibition ruxolitinib associated decreases hemoglobin platelet counts particularly first weeks therapy close monitoring blood counts careful dose management particularly early course therapy essential avoid unnecessary cytopenias may prompt premature treatment discontinuation patients otherwise would benefit continued therapy general starting doses dose reductions used recommended prescribing information based platelet counts dose escalation approach start therapy recommended patients platelet counts possible maximum tolerated doses maintained extended treatment interruptions avoided prevent lack loss treatment responses individualized dosing approach key long term treatment success
critical need evidence based broadband behavioral asd screening measures use pediatric early educational settings ensure young children risk developing social emotional disorders asd provided early intervention services optimize long term outcomes bitsea item screener designed identify social emotional behavioral problems delays deficits social emotional competence among month olds items describe behaviors consistent asd secondary data analysis employed develop cut scores asd subscales using receiver operating curves discriminating children without asd cut scores demonstrated moderate high discriminative power sensitivity specificity ppv findings highlight feasibility using broadband social emotional competence behavior problem screener improve early detection asd
background large number patients struggle migraine classified chronic disorder relative efficacy safety tolerability prophylactic medications migraine play key role managing disease methods conducted extensive literature search popular prophylactic medications used migraine patients pairwise meta analysis network meta analysis nma carried sequentially determining relative efficacy safety tolerability prophylactic medications summary effect migraine headache days headache frequency least reduction headache attacks adverse events nausea somnolence dizziness withdrawal withdrawal due adverse events produced synthesizing direct indirect evidence results patients three interventions exhibited significantly less average migraine headache days compared treated placebo topiramate propranolol divalproex moreover topiramate valproate exhibited significantly increased likelihood least reduction migraine headache attacks compared placebo patients topiramate propranolol also exhibited significantly reduced headache frequency compared placebo hand patients divalproex exhibited significantly higher risk nausea compared placebo topiramate propranolol gabapentin amitriptyline finally divalproex associated increased risk withdrawal compared placebo propranolol conclusions topiramate propranolol divalproex may efficacious prophylactic medications besides safety tolerability divalproex verified future studies
concerns expressed regarding displacement harmful emissions internal combustion engine vehicle icev tailpipes sources electricity generation used charge electric vehicles degree evs reduce environmental impacts road transportation dependent fuel mix electricity generation within country real time charging behaviours users since fuel mix electricity generation frequently changes paper analyses varying environmental impacts evs based contrasting user behaviours compares environmental impacts icevs individual user profiles developed comprise real data emerging charge events undertaken ireland information gathered actual intensity electrical grid real time allowing carbon intensity every individual charge event determined using time date information results show environmental impacts evs highly influenced charging behaviours individual users night time charging found produce largest environmental impact evs shown environmentally friendly choice vehicle icevs wide majority scenarios elsevier rights reserved
online genetic improvement embeds ability evolve adapt inside target software system enabling improve runtime without external dependencies human intervention recently developed general purpose tool enabling online genetic improvement software systems running java virtual machine tool dubbed ecselr embedded inside extant software systems runtime enabling systems self improve adapt autonomously online present tool describing architecture focusing design choices possible uses
work multimode optical fiber size effects performances clad modified fiber zno nanorods relative humidity sensor experimentally investigated simple controlled chemical etching method line monitoring used prepare different fiber waist diameter long length precisely competition behavior sensor performances varying fiber waist diameter studied find appropriate size maximizing evanescent fields obtained results revealed evanescent wave absorption coefficient gamma enhanced times compare bare fiber proposed optimum fiber diameter also high linearity fast recovery time obtained proposed fiber waist diameter applicable features proposed sensor allow device used humidity sensing applications especially applied remote sensing technologies
aim article study helper cell differentiation progression acute subacute chronic atopic dermatitis skin biopsies patients acute subacute chronic atopic dermatitis studied using immunohistochemistry antibodies tarc ccl ctack ccl rantes ccl peripheral blood mononuclear cells studied patients using flow cytometry measure content cells treg cells levels interferon ifn gamma interleukin transforming growth factor tgf beta evaluated enzyme linked immunosorbent assay elisa distinctive expressions cell specific chemokines tarc ccl ctack ccl rantes ccl observed different stages atopic dermatitis consistent differentiation cell subsets treg acute phase subsets treg chronic phase subsets early stage atopic dermatitis cells found peripheral blood mononuclear cells followed cells treg cells eosinophils late stage subacute chronic atopic dermatitis cell numbers decreased levels ifn gamma tgf beta increased progression atopic dermatitis acute chronic forms levels decreased progression atopic dermatitis acute chronic forms differentiation subsets distinct phases atopic dermatitis may form basis studies classification control increasingly common clinical condition
objective assess whether educational intervention women perimenopausal age diabetes mellitus hypertension dyslipidemia could improve aspects quality life exercise methods randomized clinical trial variables physical activity quality life weight women aged years time months surgery intervention group interactive workshops cardiovascular disease prevention control group information mail results obtained better scores mental component quality life one year later showed significant increase physical activity women maintained weight women increased conclusions simple educational intervention premenopausal women cardiovascular risk factor improves aspects quality life healthy habits physical activity sespas published elsevier espatia
employers require software engineers work teams developing software systems therefore important graduates experienced teamwork enter job market describe experiential learning exercise designed teach software engineering process conjunction teamwork skills underlying teaching strategy applied exercise maximises risks order provide maximal experiential learning opportunities students expected work fairly large yet short lived instructor assigned teams complete software engineering tasks undergoing exercise students form self selected teams capstone projects article determine report influence teaching exercise formation teams capstone project analysing data provided students regular peer reviews gain insight team dynamics well extent members contributed team effort develop present graphical model capstone project team highlights participation individuals teaching exercise participatory history members visualised using segmented concentric rings consider visualisation aid identification capstone project teams risk experience composition team behaviour members team may marked impact behaviour individual team established team classification order model information teams use statistical clustering method classify teams use team profiles based participatory levels members team types emerge clustering used derive migration models consider migration build spring models visualise teams individuals migrate colour code teams characterise according team types identified cluster classification teams owing complexity resulting model migrations capstone team members worked together exercise solitary capstone team members modelled models support identification areas interest warrant investigation conclude present observations analysis team compositions team types team migrations provide directions future work collaborations
method inhibitor containing coatings formation self healing properties surface magnesium alloys developed obtained experimental results indicate protective properties samples inhibitor containing coating increased comparison samples without coating base coating obtained plasma electrolytic oxidation method peo electrochemical parameters porous poreless layers surface samples calculated polarization due experimental impedance data modeling means equivalent electrical circuits elsevier ltd rights reserved
contemporary research documents various psychological aspects economic decision making main goal study analyse role mood maintenance hypothesis mmh financial markets mmh refers people tendency maintain positive mood states implies positive mood associated less critical thinking reduced information processing yielding three behavioral effects blue resulting stronger negative reactions bad news good mood periods sunray cloudy day leading stronger positive reactions good news bad mood periods iii shallow thinking producing stronger reactions kinds news good mood periods employing daylight duration changes measure onset recovery symptoms seasonal affective disorder sad proxies contemporaneous investors mood test role mood investors reactions analyst recommendation revisions find corroborative results notably negative stock price reactions recommendation downgrades significantly stronger daylight increasing periods alternatively periods characterized low rates onset high rates recovery sad magnitude effect increases longer event windows
paper nmos based wideband low power linear tunable transconductance current differencing transconductance amplifier cdta presented based nmos cdta novel simple easily reconfigurable configurable analogue block cab designed moreover using novel cab simple versatile butterfly shaped fpaa structure introduced fpaa consists six identical cabs could realize six order current mode low pass filter second order current mode universal filter current mode quadrature oscillator current mode multi phase oscillator current mode multiplier analog signal processing cadence design tools post layout simulation measurement results included confirm theory
era large scale data distributed systems built top clusters commodity hardware provide cheap reliable storage scalable processing massive data cheap storage instead storing currently relevant data common store much data possible hoping value extracted later way exabytes bytes data created daily basis extracting value data however requires scalable implementations advanced analytical algorithms beyond simple data processing statistical regression methods linear algebra optimization algorithms traditional methods designed minimize floating point operations dominant cost memory computation single machine parallel distributed environments however load balancing communication including disk network input output easily dominate computation factors greatly increase complexity algorithm design challenge traditional ways thinking design parallel distributed algorithms review recent work developing implementing randomized matrix algorithms large scale parallel distributed environments randomized algorithms matrix problems received great deal attention recent years thus far typically either theory machine learning applications implementations single machine main focus underlying theory practical implementation random projection random sampling algorithms large overdetermined constrained regression problems randomization used one two related ways either construct subsampled problems solved exactly approximately traditional numerical methods construct preconditioned versions original full problem easier solve traditional iterative algorithms theoretical results demonstrate near input sparsity time passes data one obtain strong relative error approximate solutions high probability empirical results highlight importance various tradeoffs time construct embedding conditioning quality embedding relative importance computation versus communication etc demonstrate regression problems solved low medium high precision existing distributed systems terabyte sized data
information system built database function without data access control component role based access control rbac models acceptable large database operating several approaches implementation modified rbac models support hierarchical temporal access control paper considers approach implementation logical level database set user role permissions tables set data access control views tables views created used according defined rules temporal access permissions distribution
article relevance using test methods pattern recognition developing intelligent systems decision making support various problem areas discussed advantage fault tolerant diagnostic tests used intelligent systems shown namely tool registering processing different kinds errors databases knowledge bases results testing two algorithms constructing nonredundant matrix implications compared technical particulars program implementation discussed synchronization means test environment test program structure bottlenecks program implementation methods elimination development parallel algorithms
economic dispatch optimal output number electricity generating units meet system load lowest possible cost subject transmission operational constraints different economic dispatch methods developed order deal challenge continuous sustainable power improved cost increase cost depletion non renewable sources forced use renewable energy resource alternative energy source optimizing economic dispatch problem new algorithm proposed based combined emission economic dispatch ceed photo voltaic plants thermal power generation units ceed approach improvising economic dispatch euclidean affine flower pollination algorithm efpa binary flower pollination algorithm bfpa used solving optimization problem twenty five thermal generators done full solar radiations reduced solar radiation power demand data taken india district tuticorin thermal power station tips simulation results tested ieee bus ieee bus systems comparison made existing algorithm provide better results elsevier ltd rights reserved
aims changes electrical activation sequence known affect timing cardiac mechanical events aim demonstrate also modify global properties intraventricular blood flow pattern also explore whether global changes present relationship clinical outcome methods results investigated heart failure patients followed cardiac resynchronization therapy crt subjects underwent echocardiography implant follow months left ventricular mechanics investigated follow active crt repeated temporary interruption min later strain analysis performed speckle tracking used assess entity contraction global longitudinal strain synchronicity standard deviation time peak radial strain intraventricular fluid dynamics echographic particle image velocimetry used evaluate directional distribution global momentum associated blood motion discontinuation crt pacing reflects reduction deformation synchrony deviation blood flow momentum base apex orientation development transversal flow mediated haemodynamic forces deviation flow momentum presents significant correlation degree volumetric reduction crt conclusion changes electrical activation alter orientation blood flow momentum long term crt outcome correlates degree alignment haemodynamic forces preliminary results suggest flow orientation could used optimizing biventricular pacing setting however larger prospective studies needed confirm hypothesis
ferroptosis newly discovered type cell death differs traditional apoptosis necrosis results iron dependent lipid peroxide accumulation ferroptotic cell death characterized cytological changes including cell volume shrinkage increased mitochondrial membrane density ferroptosis induced two classes small molecule substances known class system inhibitors class ferroptosis inducers glutathione peroxidase gpx inhibitors addition small molecule substances number drugs sorafenib artemisinin derivatives induce ferroptosis various factors mevalonate mva sulphur transfer pathways play pivotal roles regulation ferroptosis ferroptosis plays unneglectable role regulating growth proliferation types tumour cells lymphocytoma ductal cell cancer pancreas renal cell carcinoma rcc hepatocellular carcinoma hcc first introduce discovery research pertaining ferroptosis summarize induction mechanisms regulatory pathways ferroptosis finally elucidate roles ferroptosis human tumourous diseases
paper presents novel approach based integration hybrid automata real time unified modeling language uml system modeling language sysml model driven architecture mda order systematically develop controllers autonomous underwater vehicles auv approach entirely covers analysis design implementation deployment phases focused controllers auvs also allows designed control elements customizable usable development new applications various auv types paper brings step step auv dynamics together control structure specializations mda features computation independent model cim use cases hybrid automata platform independent model pim carried using real time uml well platform specific model psm implemented sub system paradigms object oriented mechanisms completely perform development lifecycle auv controllers transformation rules introduced applied convert detailed design model pim implementation model psm using open source platforms order quickly simulate realize auv controllers based approach planar trajectory tracking controller miniature autonomous submersible completely developed successfully taken trial trip application controller implemented simulation model openmodelica obtained simulation results permit mainly define designed control elements properties well building implementation libraries performing quickly realization model arduino mega microcontroller elsevier ltd rights reserved
prediabetes represents elevation plasma glucose normal range clinical diabetes prediabetes includes individuals ifg igt ifg igt elevated hbac levels insulin resistance beta cell dysfunction characteristic disorder diagnosis prediabetesis vital ifg igt indeed well known risk factors type diabetes greater risk presence combined ifg igt furthermore illustrated review prediabetes associated associated disorders typically considered established diabetes include cardiovascular disease periodontal disease cognitive dysfunction microvascular disease blood pressure abnormalities obstructive sleep apnea low testosterone metabolic syndrome various biomarkers fatty liver disease cancer vast majority individuals prediabetes unaware diagnosis therefore vital associated conditions identified particularly presence mild hyperglycemia may benefit early intervention
paper tackles problem automatic detection knee osteoarthritis computer system built takes input body kinetics produces output estimation presence knee osteoarthritis previously done literature also discriminating parameters along set rules decision reached fills gap interpretability medical engineering approaches collected locomotion data subjects knee osteoarthritis healthy subjects osteoarthritis subjects recruited hospital clinics surgeries age sex matched healthy subjects local community subjects walked walkway equipped two force plates piezoelectric component force sensors parameters vertical anterior posterior medio lateral ground reaction forces mean value push time slope extracted random forest regressors map parameters via rule induction degree knee osteoarthritis boost generalisation ability subject independent protocol employed fold cross validated accuracy show steps less reliable clinical measure extracted rule based approach dataset analysed appropriately authors published elsevier ltd behalf ipem
monitoring intraocular pressure iop critically important part glaucoma management however clinical tonometry predominantly involves sitting postures unable detect variations response posture changes muscular effort deep respirations wide range activities playing high wind resistance instruments wearing swimming goggles addition eye touching rubbing example usefulness hour tonometric phasing may increased nocturnal assessments included side prone sleeping postures rather limited supine posture tonometry continuous monitoring iop allows unrestricted involvement full range sleep non sleep iop elevating activities would provide ideal method quantifying frequency duration degree episodes elevation addition physiological pathological circadian rhythmic variations due treatment apart degree exposure episodes elevation iop genetic influences family history glaucoma factors could associated increased susceptibility develop progress glaucomatous pathology include age frailty race type degree refractive error systemic hypotension hypertension vasospasm migraine pigmentary dispersion syndrome pseudoexfoliation syndrome obstructive sleep apnoea syndrome diabetes well medication interactions side effects information combined details relating episodes elevation iop appears likely strong basis detection diagnosis treatment glaucoma review examines limitations methods longitudinal monitoring iop reference validity varying degrees invasiveness involved also mentioned potential value knowing frequency duration level variations optic nerve subarachnoid space pressure interaction changes iop potential influence lamina cribrosa may help determine pathological significance
developing video game costly activity economic perspective also terms time devoted researching innovative solutions managing interfaces creative technical team members article explore possibility use approach rooted techniques namely behaviour trees help establish lingua franca two different functions order optimize development time quality final product particular developed better middleware easily embedded game engine tested design development crazy hill commercial video game ios based mobile devices
paper proposes new high temperature superconductor hts dual rotor flux switching machine directdrive wind energy conversion key adopt dual rotor structure improve utilizations hts excitation field machine space thus achieving high power density also hts excitation easily achieve flexible flux regulation keep armature voltage constant time varying wind speeds operation principle emphasis effect relative position rotors magnetic circuits described details initial machine design especially split ratio optimization done using finite element analysis machine performances analyzed validity verified
background early adversity known risk factor unipolar depression examined impact types early adversity risk moderate severe unipolar depression adolescence adulthood evaluated whether effects moderated gender adversity timing methods conducted prospective population based cohort study using danish national registers sample included individuals born denmark exposure early adversity assessed ages types adversity included parental illness incarceration death disability psychiatric diagnosis family disruption home care childhood abuse individuals followed age first outpatient depression diagnosis icd codes psychiatric hospital death emigration december whichever came first hazard ratios hrs calculated using cox regressions results adversities significantly associated increased risk moderate severe adolescent adult depression range although effects attenuated mutual adjustment adjusted range none effects moderated gender effect family disruption strongest ages effect home care strongest ages limitations untreated primary care treated depression measured conclusions results support past findings multiple types early adversity increase risk moderate severe unipolar depression adolescence adulthood certain adversities may harmful occur specific developmental time periods
randomized algorithms deep learning techniques successfully used regression classification problems however random hidden weights randomized algorithms require suitable distributions advance deep learning methods use output information system identification paper distributions hidden weights obtained restricted boltzmann machines deep learning method uses input data construct statistical features hidden weights output weights neural model trained normal randomized algorithms successfully combine unsupervised training deep learning supervised learning method randomized algorithm take advantages proposed randomized algorithms deep learning modification validated three benchmark problems elsevier inc rights reserved
argue processor microarchitectures today microcontrollers poorly matched computational workloads iot edge nodes largely independent chains processes manage dynamic mixture periodic sporadic tasks must executed real time hardware support priorities tasks software support priorities others impedes efficient correct design single monolithic alu bottleneck diverse asynchronous computational demands workloads describe new processor microarchitecture hardware support unified fine scale priorities processes dispatch issue execute pipeline supporting process level parallelism datapath includes multiple functional units enabling parallel processing via dynamic matching resources demand set functional units includes computational assets reflect needs iot nodes including crypto primitive generation engine
objective bilateral tubal ligation btl common form birth control united states limited contradictory data examining btl risk endometrial cancer none examining type type cancers separately investigated association btl endometrial cancer risk using women health initiative whi observational dietary modification studies methods demographic information history btl obtained baseline questionnaires whi participants observational dietary modification studies univariable multivariable models used examine association btl type type endometrial cancers results total women diagnosed incident endometrial cancer type type mean follow years overall women undergone btl statistically significant associations noted btl age btl type type cancers conclusions examined largest patient cohort date effort determine impact btl endometrial cancer risk whi trial observed overall effect btl risk type type endometrial cancer suggesting patients undergoing popular birth control method likely associated change baseline risk endometrial cancer
aim hypothesised atopic dermatitis dysfunctional skin barrier facilitates transcutaneous presentation allergens immune system study examined whether atopic dermatitis increased likelihood polysensitisation namely sensitisation five allergens methods examined electronic hospital charts children aged years visited primary secondary care physicians allergic symptoms whose blood examined presence specific immunoglobulin ige common inhaled food allergens whose files contained documentation presence atopic dermatitis skin disorders sensitisation defined specific ige level results polysensitisation common children atopic dermatitis without remained significant adjustment gender age multiple logistic regression model odds ratio confidence interval skin disorders show increased risk polysensitisation conclusion polysensitisation considerably common children atopic dermatitis without supports hypothesis sensitisation occurs defective skin barrier appears specific atopic dermatitis
aim recent years cases chronic myeloid leukemia cml reported bcr abl jakvf mutations moreover mutations additional sex comb like asxl gene recently shown various myeloid malignancies previous studies investigating incidence asxl jakvf mutations iranian patients cml consequently study focuses analysis mutations patients cml methods total patients clinical diagnosis cml examined time diagnosis thirty healthy subjects checked controls exon asxl amplified genomic dna bidirectionally sequenced also performed jakvf screening amplification refractory mutation system polymerase chain reaction sequencing results mutations asxl gene found five cml patients identified novel variant aspasn one patients reported also identified bcr abl jakvf mutations simultaneously four patients conclusion demonstration asxl mutation putative tumor suppressor gene represents important molecular abnormality cml also showed concomitant detection bcr abl jakvf mutations relatively high incidence iranian patients
development digital control technology sampled data control shows prominent superiority practical industries framework sampled data control paper studies stabilization problem class switched linear neutral systems meanwhile taking account asynchronous switching utilizing relationship sampling period dwell time switched neutral systems bond sampling period average dwell time revealed form switching condition certain control gains conditions exponential stability closed loop systems guaranteed simple example given demonstrate effectiveness proposed method elsevier ltd rights reserved
leaf movements mimosa pudica response thermal stress touch light darkness appear regulated electrical hydrodynamical chemical signal transduction pulvinus pudica shows elastic properties found movements petiole pinnules accompanied change pulvinus morphing structures brief flaming pinna volume lower part pulvinus decreases volume upper part increases due redistribution electrolytes parts pulvinus result changes petiole falls relaxation petiole process goes opposite direction ion water channel blockers uncouplers well anesthetic agents diethyl ether chloroform decrease speed alert wave propagation along plant brief flaming pinna induces bidirectional propagation electrical signal pulvini transduction electrical signals along pulvinus induces generation action potential perpendicular direction extensor flexor sides pulvinus inhibition signal transduction mechanical responses pudica volatile anesthetic agents chloroform blockers voltage gated ion channels shows generation propagation electrical signals primary effect responsible turgor change propagation excitation electrical coupling pulvinus similar electrical synapse animal nerves elsevier gmbh rights reserved
performance tasks requiring discrimination least two stimuli viewed either objective perspective referring actual stimulus differences subjective perspective corresponding participant responses using event related potentials recorded old new recognition memory test involving emotionally laden neutral words studied either blockwise randomly intermixed show objective perspective old versus new items yields late effects blockwise emotional item presentation parietal sites subjective perspective fails find whereas subjective perspective old versus new responses sensitive early effects emotion anterior sites objective perspective results demonstrate potential advantage dissociating subjective objective perspective onto task performance addition analyzing trials correct responses especially investigations illusions information processing biases behavioral cognitive neuroscience studies elsevier inc rights reserved
century old clinical reports document periosteum remarkable regenerative capacity past decade scientists undertaken mechanistic investigations regenerative potential workshop annual meeting orthopaedic research society reviewed molecular cellular tissue scale approaches elucidate mechanisms underlying periosteum regenerative potential well translational therapies engineering solutions inspired remarkable regenerative capacity entire population osteoblasts within periosteum endosteal trabecular bone surfaces within bone marrow derives embryonic perichondrium periosteal cells contribute cartilage bone formation within callus fracture healing cells bone marrow endosteum migrate marrow compartment furthermore current healing paradigm regards activation expansion differentiation periosteal stem progenitor cells essential step building template subsequent neovascularization bone formation remodeling periosteum comprises complex composite structure providing niche pluripotent cells repository molecular factors modulate cell behavior periosteum advanced smart material properties change depending mechanical chemical biological state tissue understanding periosteum development progenitor cell driven initiation periosteum endogenous tissue building capacity complex structurefunction relationships periosteum advanced material important harnessing engineering ersatz materials mimic periosteum remarkable regenerative capacity orthopaedic research society published wiley periodicals inc orthop res
considering unique nature online environments limit aspects nonverbal communication fostering robust lasting teacher student relationships online classes may challenging moreover structural features online settings may create learning environment students minimal knowledge instructor role teacher self disclosure learning settings rarely tested although decades instructional communication research demonstrate significance structural equation model analysis results suggest teacher self disclosure students emotional responses toward teacher enhance teacher student relationship satisfaction turn increases perceived knowledge gain class satisfaction current study compares teacher impacts online ftf classes conducting multiple group comparison analysis findings suggest effect teacher upon teacher student relationship satisfaction stronger online compared ftf classes elsevier ltd rights reserved
early diagnosis social isolation older adults prevent physical cognitive impairment impoverishment social network diagnosis usually performed personal periodic application psychological assessment instruments situation encourages development novel approaches able monitor risk situations social interactions obtain early diagnosis implement appropriate measures paper presents development prediction model social isolation older adults ambient intelligence ami social networking sites snss predictive model evaluated terms accuracy sensitivity specificity predictive values paper also presents results experimental test applying proposed approach real users obtaining prediction accuracy type error rate proposed model benefit institutions interested developing technological solutions detect early stages social isolation resulting improving quality life older adults
cyclic amp regulatory element binding protein signal transducer activator transcription stat may control inflammation several mechanisms one best characterized induction expression anti inflammatory cytokine interleukin stat also regulates production pro inflammatory cytokines induced immunoreceptor tyrosine based activation motif itam coupled receptors mechanism termed cross inhibition signalling via itam dependent mechanisms hallmark fungal pattern receptors stat activation might involved cross inhibition associated invasive fungal infections fungal surrogate zymosan produced phosphorylation stat expression ifnb socs induce interferon ifn signature cytokines cxcl cxcl bone marrow derived dendritic cells unlike lipopolysaccharide lps zymosan induced phosphorylated stat similar extent irf ifnar knockout wild type mice human dendritic cells showed similar results although induction ifnb less prominent results indicate lps zymosan activate stat different routes whereas type ifn main effector lps effect mechanism involved stat phosphorylation zymosan complex associated type ifn granulocyte macrophage colony stimulating factor seems dependent several factors given partially inhibited platelet activating factor antagonist web high concentrations cox inhibitors mitogen activate protein kinase inhibitors blockade tumour necrosis factor alpha function altogether results indicate fungal pattern receptors share itam coupled receptors capacity produce cross inhibition mechanism involving stat induction socs explained type ifn signalling
recently subspace fitting approach proposed vibration based finite element model updating approach makes use subspace based system identification extended observability matrix estimated vibration measurements finite element model updating performed correlating model based observability matrix estimated one using single set experimental data hence updated finite element model reflects single test case however estimates vibration measurements inherently exposed uncertainty due unknown excitation measurement noise finite data length paper covariance estimation procedure updated model parameters proposed propagates data related covariance updated model parameters considering first order sensitivity analysis particular propagation performed iteration step updating minimization problem taking account covariance updated parameters data related quantities simulated vibration signals used demonstrate accuracy practicability derived expressions furthermore application shown experimental data beam elsevier ltd rights reserved
coincident simultaneous three component particle velocity measurements performed using two laser doppler anemometry probes outlet section high cylindrical riser first time presented dilute flow conditions near blinded extension outlet solids vortex formed particle downflow along riser wall opposite outlet tube observed restricted higher riser heights higher gas flow rates increased velocity fluctuations observed solids vortex downflow region well heights corresponding outlet tube contrary rest riser downflow region time ensemble velocity averages equal given local bending streamlines axial momentum transforms radial azimuthal momentum giving rise corresponding shear stresses turbulence intensity values indicate edges downflow region authors aiche journal published wiley periodicals inc behalf american institute chemical engineers aiche
two solutions data security field ensuring legitimate recipients access intended data steganography cryptography solutions used providing high level security exponential growth challenges field computer security use bluetooth technology expanding rapidly expose many challenges surface one challenges mitm attack bluetooth pairing process paper steer wheel concoct novel method based steganography fortify pairing process thwart mitm attacks light study thorough experiment conducted based proposed method moreover provide results experiment order show applicability novel method furthermore sketch new ideas used future research work
imidafenacin antimuscarinic agent treating overactive bladder antidiuretic effect detailed mechanisms action remain unclear cholinergic vasopressin systems known interact example suppression vasopressin induced water reabsorption muscarinic stimulation renal collecting duct therefore investigated whether vasopressin signaling pathway would participate antidiuretic effect imidafenacin female sprague dawley rats urine production measured collecting urine cystostomy chatheter using bollman restraining cage drug injection water load imidafenacin vasopressin receptor agonist desmopressin acetate desmopressin dose dependently suppressed urine production combination imidafenacin desmopressin minimum effective doses suppressed urine production strongly alone mozavaptan hydrochloride mozavaptan vasopressin receptor antagonist completely inhibited antidiuretic effects imidafenacin desmopressin respective minimum effective doses antidiuretic effect desmopressin emerged maximum antidiuretic dose level even mozavaptan treatment whereas imidafenacin still kept suppressed mozavaptan imidafenacin added combination mozavaptan desmopressin antidiuretic effect enhanced present study suggests vasopressin signaling pathway participates antidiuretic effect imidafenacin imidafenacin exerts antidiuretic effects enhancing part vasopressin signaling pathway orally water loaded rats elsevier rights reserved
human robot interaction scenarios intelligent robot able synthesize appropriate behavior adapted human profile personality recent research studies discussed effect personality traits human verbal nonverbal behaviors dynamic characteristics generated gestures postures nonverbal communication differ according personality traits similarly influence verbal content human speech research tries map human verbal behavior corresponding verbal nonverbal combined robot behavior based extraversion introversion personality dimension explore human robot personality matching aspect similarity attraction principle addition different effects adapted combined robot behavior expressed speech gestures adapted speech robot behavior interaction experiments humanoid nao robot reported
guillain barre syndrome gbs acute inflammatory demyelinating polyradiculopathy resulting severe impairments many body structures functions consequent limitations activities participation aim study evaluate rehabilitation outcome patients forty five women men gbs patients completed primary comprehensive rehabilitation included study medical research council scale muscle strength used assessment lower limb function patients activities assessed using functional independence measure two walking tests min patients also described using adapted international classification functioning disability health checklist assessment performed admission discharge clinically important statistically significant improvements found outcome measures strong significant correlations found outcome measures international classification functioning disability health coding also clearly reflected progress improvement patients activities increased statistically significantly time months rehabilitation outcome related time interval establishing diagnosis start rehabilitation hence multidisciplinary care gbs patients effective clinically important statistically significant improvements regarding body functions activities achieved relatively short inpatient rehabilitation copyright wolters kluwer health inc rights reserved
objective examine association media violence exposure physical aggression fifth graders across media types methods analyzed data population based cross sectional survey fifth graders parents metropolitan areas used multivariable linear regression report partial correlation coefficients examine associations children exposure violence television film video games music reported time spent consuming media reported frequency violent content physical fighting hurting shooting killing problem behavior frequency scale results child reported media violence exposure associated physical aggression multivariable adjustment sociodemographics family community violence child mental health symptoms partial correlation coefficients video games music association significant independent television video games music violence exposure model including media types partial correlation coefficients video games music significant positive interaction media time media violence video games music television effect sizes association media violence exposure physical aggression greater magnitude examined variables conclusions association physical aggression media violence exposure robust persistent strength association media violence may least important factors physical aggression children neighborhood violence home violence child mental health male gender
microrna mir frequently dysregulated many types cancer however function mir glioma remains unknown present study aimed investigate biological functions mir glioma potential molecular mechanism mir involved glioma progression found mir expression significantly reduced glioma specimens cell lines detected real time quantitative polymerase chain reaction qpcr analysis overexpression mir inhibited suppression mir promoted cell migration invasion epithelial mesenchymal transition emt glioma cells bioinformatics analysis showed cell specific moloney murine leukemia virus insertion site bmi direct target mir validated dual luciferase reporter assay qpcr western blot analysis restoration bmil expression significantly abrogated suppressive effect mir glioma cell emt taken together present study suggests mir inhibits glioma cell emt targeting bmil providing novel insights understanding pathogenesis glioma restoration mir may potential therapeutic strategy glioma treatment
paper presents new realization transadmittance mode universal filter three inputs single output circuit employs two current differencing transconductance amplifier cdta two capacitors two resistors one cdta multiple outputs hence called mocdta configuration realizes low pass high pass band pass notch filter using cmos based cdta greatly reduces space requirement power consumption circuit offers advantages low input impedance high output impedance active passive sensitivities low natural angular frequency omega quality factor proposed filter electronically controlled pspice simulation results included verify theoretical analysis
paper presents design cmos chua type analog chaos circuit using signal flow graph sfg method circuit transmittance nonlinear element realized ota feedback resistor linear elements realized amp based circuits proposed circuit insensitive finite admittance ota parasitics resistors except feedback resistor nonlinear element performance chaotic behavior proposed circuit confirmed spice simulations
aim study investigate association different dental prophylactic modalities osteoradionecrosis orn determine risk orn different timing periods scaling use chlorhexidine mouth rinse surgery different strategies fluoride gel application head neck cancer hnc participants cohort hnc participants including orn patients matched control cases enrolled longitudinal health insurance database catastrophic illness patients lhid cip taiwan based different dental prophylactic modalities radiotherapy including chlorhexidine mouth rinse scaling fluoride gel hnc subjects stratified different groups cox proportional hazard regression used compare orn incidences different dental prophylactic modalities results revealed scaling chlorhexidine mouth rinse significantly related orn risk chlorhexidine mouth rinse highly correlated orn occurrence hazard ratio exposure increased risk fold among oral cancer patients regardless whether received major oral surgery oral cancer patients receiving scaling within radiotherapy increased incidence orn fold compared patients undergone scaling within significance fluoride application dental prophylaxis increasing orn occurrence conclusion dental prophylaxis radiotherapy strongly correlated orn hnc patients chlorhexidine exposure dental scaling within radiotherapy significantly related orn risk especially oral cancer patients use naf topical application significantly increase risk orn hnc patients optimal dental prophylaxis protocol reduce orn concern cancer location cautious prescription chlorhexidine mouth rinse proper timing scaling
adult female within estrous cycle mammary gland undergoes multiple rounds growth increased cellular proliferation involution increased apoptosis increase proliferation elicited endocrine estrogen progesterone well locally produced epidermal growth factor insulin like growth factor etc growth factors among genes modulated cellular proliferation immediate early genes play fundamental role rapidly upregulated regulated within phase cell cycle allowing progression subsequent phases egrs immediate early genes encode transcription factors promote within different cell types depending strength duration stimuli several different responses like mitogenesis differentiation apoptosis even anti apoptosis work studied mechanisms modulation egr family mammary epithelial cells different origin bovine canine feline murine following stimulation growth medium egr mrna expression showed strong upregulation reaching peak min rapidly declined among several cytokines particularly important mammary morphogenesis tested egf igf insulin estrogen progesterone egf upregulated egrs levels close elicited growth medium order understand egr transcription factors regulated inhibited erk pik molecules drive two major intracellular signaling pathways inhibition erk pathway totally abolished egr upregulation mediated growth medium egf hand pik akt pathway played minor role egr levels strong inhibitory effect cat cells could ascribed reduced erk phosphorylation following pik inhibition finally showed addition growth medium also upregulated mammary luminal marker cytokeratin murine nmumg cell line first manuscript describing egr transcription factors expressed mammary epithelial cells domestic animals growth factors signaling pathways modulate expression elsevier inc rights reserved
function transformation presented change kind nonlinear coupled system set two elliptic equations first kind new infinite sequence complexion two soliton solutions kind nonlinear coupled system constructed new solutions backlund transformation elliptic equation first kind
american sign language asl fingerspelling act spelling word letter letter specific sign exist represent synthesizing intelligible asl includes fingerspelling integral part important create signing virtual characters training communicating virtual environments applications rhythm speed fingerspelling play large role well fingerspelling understood using motion capture technologies record fingerspelling analyze timing information letters words goal identify fingerspelling timing information use create fingerspelling animations natural understandable
high power grid connected inverters lcl filters widely used current control plays key role grid connected inverter control system cope inherent resonance lcl filter active damping methods usually employed however performance impaired control delays introduced digital control implementation process besides lag phase due control delays limits system bandwidth stability margin effects control delays noteworthy high power grid connected inverter due low switching frequency paper investigates current control strategy based multisampling high power grid connected inverter lcl filter first multisampled scheme studied reduce control delays effectively improve performance besides multisampled control without additional damping whether passive active researched inverter side current feedback system realize single current loop control based multisampling thus control system simplified stable achieve better dynamic performance finally experimental results show proposed control schemes effective
reverse osmosis process used many industrial applications ranging solute solvent solvent solvent gaseous separation number theoretical models developed describe separation fluxes solvent solute processes paper looks scope limitations two main models irreversible thermodynamics solution diffusion models used past several researchers solute solvent feed separation despite investigation complex models simple concepts models accelerate feasibility implementation reverse osmosis different types systems variety industries briefly extensive review mathematical models conducted collecting examples literature study addition review covered improvement models make compatible multi component systems consideration concentration polarization solvent solute membrane interaction elsevier ltd rights reserved
cable important component cable supported bridges roof structures existing vibration methods cable tension estimates mainly based measured acceleration responses practice relatively expensive time consuming due required installation contact type sensors data acquisition systems study novel noncontact vision based sensor proposed accurate cost effective alternative determination cable tension forces noncontact measurement capacity vision sensor eliminates need access cable install conventional sensors may highly difficult risky proposed method applied measure cable forces cable supported roof structure hard rock stadium florida ensure cable forces reach design values series field tests carried different roof erection stages satisfactory agreements observed measured cable forces vision based sensor reference readings load cells proposed method represents convenient low cost method either periodic long term monitoring cable supported structures elsevier ltd rights reserved
staff removal image processing task aims facilitate analysis music score images even restricted images specific domains music score recognition solving image processing problems usually requires design customized algorithms cope image variabilities growing amount data machine learning based techniques emerge natural approach employed image processing problems sense image operator learning methods concerned estimating sample pairs input output images transformation local function characterizes image transformation methods require definition parameters including local information considered processing defined window work show apply image operator learning technique staff line removal problem present algorithm window determination show captures visual information relevant staff removal also present reference window set used cases training set sufficiently large experimental results obtained respect synthetic handwritten music scores varying image conditions show learned image operators comparable especially designed state art heuristic algorithms
throughout history one fascinating topics psychiatry causes consequences mental disorders desire strengthen reliability diagnosis area led significant advances two important fields psychopathological description formulation integral diagnosis classifications allow definition categories case two read taxonomies field mental health diagnostic statistical manual mental disorders dsm international classification diseases icd provide commonly used criteria diagnosis revised fourth edition dsm insufficient cover ever greater clinical challenges research ten years work carried structure dsm fifth edition despite planning organization prediction contributions guest experts feared requirements modern psychiatry met first edition dsm published based terminology developed william meninger version manual following published several years later reflected psychodynamic psychiatry prevailed time third edition published revised edition seven years later emphasis descriptive syndromatic considerations fourth edition appeared several years later striking change edition inclusion variables resulting empirical studies later edition published year first attempts put together dsm started work done planning investigation technical documentation dsm inclusion called investigation schedules second phase project known refinement research program dsm carried pilot test undertaken january may among different segments population different settings evaluate revisions proposed working teams march april result field tests proposed criteria diagnosis reviewed dimensional measurements criteria diagnosis reviewed rest year see preparation final version text finally may dsm presented annual meeting american psychiatric association san francisco california several external independent authors offered numerous proposals topics related psychopathology general working groups formed preparation dsm mentioned one first factors taken consideration revision manual need distinguish empirical questions approaches conceptual philosophical nature means excluded another point evaluated advisability defining phases according development condition would ideally create schema focused prevention one expectations psychiatry eventually laboratory criteria diagnosis could established could measurable would lead clear statistics psychiatric pathologies far somatomorphic disorders concerned many practitioners agree current terminology systems classification inaccurate one proposal category eliminated altogether diagnoses made using additional multidimensional description one interesting features dsm accommodate changes brought new technologies advances hand hand new series pathologies need classified addiction internet undoubtedly one greatest dilemmas facing dsm classify eating disorders many people feel rather simplistic distinction nervous anorexia bulimia altogether convincing two interesting proposals consider dsm one known night eater syndrome obesity case compulsive consumption food inability limit intake spite desire regard compulsive obsessive disorder experts believe necessary see disorder spectrum defining criteria undeniably grave current problem makes distinctions suicide different researchers recommend suicidal behavior considered documented separate diagnosis sixth axis multioxis schema another important aspect concerns giving quality attention patients led proposal expand dsm include indicators situations could eventually cause treatment proposal structure something different found axis case paraphilias deemed necessary dsm deal strictly descriptive aspect also semantic linguistic importance post traumatic stress described exists doubt whether necessary experience adverse incident triggered suggestion term pre traumatic stress disorder included dsm diagnose condition case anxiety disorders authors advise creation category known disorders caused stress fear would allow linking diagnostic classification etiology thus define true anxiety nosology would advisable dsm included category seasonal affective disorder simply variant specification seasonal pattern depression field substance consumption argued necessary establish classification categoric also dimensional improve taxonomic usefulness organization mental disorders dsm icd tenth edition complex led exploring feasibility developing meta structural system classification based risk clinical factors disorders originated infancy childhood adolescence suggested disorder known temperament disorder disphoria included forthcoming taxonomy well use terms insensitive emotionless behavioral disorders among others case attention deficit hyperactivity disorder adhd current criteria considered insufficient suggested starting age disorder increased years age suggested autism considered autistic spectrum thus eliminating disorders covered section including asperger syndrome question whether taxonomic diagnostic system implemented world wide valid reliable enough cover variations particular characteristics different cultures ethnic groups social groups geographical regions mexico another matter concern due lack tools available daily clinical work except international classification diseases world health organization present number doubts queries need laid open evaluated seriousness order obtain concrete integral answers given manual continue used clinical purposes different parts world challenge find best way apply diagnostic criteria avoiding omissions oversimplifications taking account cultural social context worked
recent years convolutional neural networks cnns important parts deep neural networks dnns achieved great successes field computer vision however convolution always takes much computation time dnns order improve efficiency cnns many solutions focusing training algorithms parallelism strategies proposed paper different traditional gpu based algorithms novel algorithm based look table proposed speed cnns small filters applying gpu transforming complex matrix multiplications operations convolution computation table based simple summation operations overhead convolution computation considerably reduced process creating table looking values table appropriate parallelization gpu experimental results show proposed approach improve speed convolution computation compared existing state art works less accuracy loss
purpose additive manufacturing processes integration many different science engineering related disciplines material metrology design process planning situ line measurements controls major integration challenges arise increasing complexity systems lack support among vendors interoperability result data readily shared among components system attempt better homogenization data paper aims provide reference model data sharing activities taken process laser based powder bed fusion pbf design methodology approach activity model identifies requirements developing process data model authors approach begins formally decomposing pbf processes using activity modeling methodology resulting activity model means structure process related pbf data align data specific pbf sub processes findings model paper provides means understand organization process activities sub activities flows among pbf processes research limitations implications model modeling activities data associated activity data modeling included work social implications modeling selected pbf process sub processes activities authors discuss requirements developing development advanced process data models models provide common terminology new process knowledge improve data management various stages originality value fundamental challenges sharing reusing data among heterogeneous systems include lack common data structures vocabulary management systems data interoperability methods paper authors investigate challenges specifically relate process information pbf captured represented stored accessed focus using methodical information modeling techniques context design process planning fabrication inspection quality control
due frequency phenomenon often considerable distress caused affected person competent advice diagnosis treatment snoring adults particular importance aim guideline promote high quality medical care patients affected problem according three level concept awmf corresponds guideline prior therapeutic intervention relevant sleep medical history clinical examination well mandatory objective diagnostic measure performed snoring treated patient asks general invasive methods viewed critically patient advised correspondingly case surgical therapy minimally invasive techniques preferred reducing body weight case overweight snorers abstinence alcohol nicotine sleep medication well maintaining healthy sleep wake cycle recommended sleep medicine perspective although convincing clinical studies yet available since evidence effectiveness muscle stimulation various methods toning training muscles floor mouth available methods recommended snoring successfully treated use intraoral device however careful patient selection important avoiding supine position sleep helpful cases limited data available success rates surgical approaches long term data often lacking techniques sufficiently evaluated scientific point view nasal surgery indicated patient suffers nasal obstruction extensive data supports effectiveness laser assisted resection excessive soft palate tissue laser assisted uvuloplasty laup principle however resections performed using techniques placebo controlled studies able prove effectiveness radiofrequency surgery soft palate reduction snoring could also achieved many cases means soft palate implants minimal post operative morbidity indication tonsillectomy uvulopalatopharyngoplasty made cautiously due comparatively high morbidity associated procedures
last decade biology medicine undergone fundamental change next generation sequencing ngs technologies enabled obtain genomic sequences quickly small costs compared traditional sanger method ngs technologies thus permitted collect genomic sequences genes exomes even full genomes individuals species latter sequences identical thus strong need efficient algorithms indexing performing fast pattern matching specific sets sequences paper propose efficient algorithm solves exact pattern matching problem set highly similar dna sequences pattern pre processed new algorithm extends variants boyer moore exact string matching algorithm experimental results show exhibits best performances practice
reparameterization surfaces widely used tool computer graphics known mostly remeshing algorithms recently surface reparameterization techniques started gain popularity field medical imaging mostly convenient visualization information initially represented surfaces continuous bulls eye plot however consistently mapping information domain surface reparameterization techniques allow put correspondence anatomical shapes inherently different geometry paper propose method anatomical parameterization cardiac ventricular anatomies include myocardium trabeculations tendons papillary muscles proposed method utilizes quasi conformal flattening myocardial surfaces left right cardiac ventricles extending cover interior cavities using local coordinates given solution laplace equation subsequently define geometry independent representation detailed cardiac left right ventricular anatomies used convenient visualization statistical analysis trabeculations population lastly show used mapping detailed cardiac anatomy different hearts considerable interest detailed cardiac computational models shape atlases elsevier rights reserved
background animal efficiency converting feed lean gain critical issue profitability meat industries study aimed describe shared specific molecular responses different tissues pigs divergently selected eight generations residual feed intake rfi results pigs low rfi line improved gain feed ratio test period displayed higher leanness similar adiposity compared pigs high rfi line days age transcriptomics data generated longissimus muscle liver two adipose tissues using porcine microarray analyzed line effect pigs per line apparent effect line seen muscle whereas subcutaneous adipose tissue less affected tissue molecular data analyzed bioinformatics subjected multidimensional statistics identify common biological processes across tissues key genes participating differences genetics feed efficiency immune response response oxidative stress protein metabolism main biological pathways shared four tissues distinguished pigs low high rfi lines many immune genes expressed four tissues efficient pigs main genes contributing difference pigs low high rfi lines ctsc ntn different genes associated energy use modulated tissue specific manner two lines gene expression program related glycogen utilization specifically regulated muscle pigs low rfi line efficient genes involved fatty acid oxidation regulated muscle promoted adipose tissues pigs compared pigs high rfi line less efficient underlined opposite line associated strategies energy use skeletal muscle adipose tissue genes related cholesterol synthesis efflux liver perirenal fat also differentially regulated pigs low high rfi lines conclusions non productive functions immunity defense pathogens oxidative stress contribute likely inter individual variations feed efficiency
nonwoven geotextiles used filters four decades geotechnical geoenvironmental works products complex fibre matrix behaviour filters depends matrix interacts fluids soil particles therefore uncertainties still exist regarding prediction geotextile filter performance severe critical situations paper investigates confinement partial clogging influence dimensions openings nonwoven geotextiles bubble point bbp tests carried six nonwoven geotextiles unconfined confined equivalent vertical stresses kpa conditions without partial clogging geotextile results obtained show significant influences confinement partial clogging geotextile opening dimensions retention capacity results bubble point tests unconfined virgin specimens compared well results hydrodynamic tests comparisons bbp results data filtration tests confinement also presented discussed repercussions reductions opening size caused confinement partial clogging geotextile clogging potential filter criteria discussed
aim paper propose low cost automated furnace control system heat treatment steel used open source electronic prototyping platform control furnace temperature thus reducing human interaction heat process platform adapted non controlled commercial furnaces often used small businesses proportional integral derivative pid controller implemented regulate furnace temperature based defined heat treatment cycle embedded system activates furnace resistors pulse width modulation pwm allowing control electrical power supplied furnace hardening tempering performed standard steel samples using traditional method visual inspection without temperature control well embedded system pid feedback control results show proposed system reproduce arbitrary heat treatment curve accuracy provide desired final hardness inferred metallographic analysis addition observed saving energy consumption using proposed control system furthermore estimated cost implement system lower commercial controller model implemented commercial furnaces elsevier ltd rights reserved
consider well known distributed setting computational mobile entities called robots operating euclidean plane look compute move lcm cycles investigate computational impact expanding capabilities robots endowing externally visible memory register called light whose values called colors persistent automatically reset end cycle refer endowed entities luminous robots study computational power luminous robots respect three main settings activation synchronization fully synchronous semi synchronous asynchronous establish several results main contribution constructive proof asynchronous robots illuminated constant number colors strictly powerful traditional semi synchronous robots also constructively prove luminous robots difference asynchrony semi synchrony disappears result must contrasted strict dominance models without lights even robots enhanced unbounded amount persistent internal memory additionally show problems robots solve without lights even fully synchronous solved asynchronous luminous robots colors still open whether asynchronous luminous robots colors powerful fully synchronous robots without lights prove indeed case robots additional capability remembering single snapshot turn shows asynchronous robots colors single snapshot renders powerful unlimited amount persistent memory including snapshots lights elsevier rights reserved
recently crimes cause internet hacking target one companies financial due massive crimes caused digital convergence ubiquitous system clear amount network packet need processed rising digital convergence ubiquitous system caused ids intrusion detection system process packets past snort version leading open source ids long history since built long time ago several limitations fit today requirements processing unit single threading hand suricara built cover snorts disadvantages cover massive amount packets caused digital convergence ubiquitous system suricata availability process packets multi threading environment paper analyzed compared snort suricata processing detection rate decide better single threading multi threading environment
new era cyber physical systems software must adapt ever changing environmental conditions situations currently reflected design embedded operating systems since primarily optimized fixed usage scenarios tight resource constraints discuss idea interpreted operating system kernels form new foundation highly reconfigurable embedded systems paper elaborates reasonable use cases shows comparable approaches past sketches implementation strategy based bare metal python interpreter
despite growing evidence support mindfulness underlying mechanism mindfulness based interventions mbis suggested nonspecific therapeutic factors experience social support may contribute positive effects mbis present study examined whether change mindfulness social support mediated effect mindfulness based cancer recovery mbcr compared another active intervention supportive expressive group therapy set change mood disturbance stress symptoms quality life secondary analysis conducted multi site randomized clinical trial investigating impacts mbcr set distressed breast cancer survivors mindset applied causal steps approach bootstrapping test mediation using pre post intervention questionnaire data participants randomised mbcr set mbcr participants improved significantly mood disturbance stress symptoms social support quality life mindfulness compared set participants increased social support partially mediated impact mbcr versus set mood disturbance stress symptoms group differences mindfulness quality life observed mediation analyses performed variables findings showed increased social support related improvement mood stress mbcr compared support groups whereas changes mindfulness suggests important role social support enhancing outcomes mbcr previously thought
autism spectrum disorder asd increasingly conceptualized spectrum disorder connectome development review evidence suggesting asd characterized positive feedback loop amplifies small functional variations early developing sensory processing pathways structural functional imbalances global neuronal workspace using vision example discuss early functional variants visual processing may feedback amplified produce variant object categories disrupted top expectations atypically large expectation perception mismatches problems identifying individual people objects socially inappropriate generally aversive emotional responses disrupted sensory motor coordination viewing asd terms feedback amplification small functional variants allows number recent models asd integrated neuroanatomical neurofunctional genetic data
new image analysis algorithm based mathematical morphology pixel classification grapevine berry counting presented paper first set berry candidates represented connected components extracted six descriptors calculated using key features components employed false positive discrimination using supervised approach specifically set descriptors modelled grapes distinctive shape light reflection pattern colour two classifiers tested three layer neural network optimised support vector machine dataset images acquired low cost smart phone camera images came seven grapevine varieties per variety two phenological stages baggiolini scale berry set named stage images cluster closure named stage images images kept external validation remaining used training stage training images true false positive samples generated labelled terms six descriptors neural network performed better support vector machine yielding consistent recall precision average values respectively presented algorithm implemented smartphone application constitute useful diagnosis tool field non destructive yield prediction berry set assessing grape wine industry iagre published elsevier ltd rights reserved
phase stability diagrams carbothermal reduction mixture tio constructed function carbon activity oxygen pressure characteristics solution formation found stable domains carbides carbonitrides including larger phases formed solid solution phases considered due greater stability use nitrogen atmosphere instead vacuum expanded stable domains solid solution phases indicating made stable conditions using stability diagrams reaction sequence carbothermal reduction predicted study provide guideline preparing tougher carbide carbonitride phases tio mixtures elsevier ltd rights reserved
article presents study supported social enterprise hybrid organization either employs trains members marginalized social groups often disability pensions social assistance also social welfare characteristics organizations sell services goods like forms social enterprise rely heavily external support government programs foundations parenting nonprofit article presents empirical study using survey interviews participants organizations ontario canada notes even though earn minimally work organizations view experience positively final discussion centers concept supported social enterprise raises question whether organizations viewed primarily form social enterprise modified form social welfare organization
establish adequate thermodynamic model mechanism formation hydrogen sulfide corrosion products theoretical experimental studies combined work corrosion products api pipeline steel formed different corrosion conditions analyzed scanning electron microscopy energy dispersive ray spectroscopy ray diffraction thermodynamic model developed clarify environmental boundaries formation transformation different products presumably dividing line negative slope existed mackinawite pyrrhotite using experimental data presented study combined previously published results validated model predict formation mackinawite pyrrhotite basis laws thermodynamics established relationship expected support investigation corrosion mechanism oil gas industry
increasing evidence positive affect enhances associative processing lent weight idea positive affect increases false memory information thematically interrelated using deese roediger mcdermott paradigm examined whether mild positive affect facilitates monitoring processes modulating false memory associate words participants warned condition contrast unwarned condition overtly warned possible false recognition critical lure found positive affect compared neutral affect significantly enhanced monitoring warning reduced false recognition signal detection analyses suggest warning provided positive affect enhances sensitivity discriminate list items critical lures shift overall decision criterion taken together conclude positive affect facilitates effect warning reducing false memories semantic associates
previous cross sectional studies suggested association migraine rheumatoid arthritis longitudinal study performed evaluate temporal relationship two conditions purpose present population based propensity score matched cohort study investigate whether migraineurs higher risk developing total subjects aged years least two ambulatory visits diagnosis migraine recruited migraine group fit logistic regression model included age sex comorbid conditions socioeconomic status covariates compute propensity score non migraine group consisted propensity score matched randomly sampled subjects without migraine free survival curves generated using kaplan meier method stratified cox proportional hazard regression used estimate effect migraine risk follow subjects migraine group non migraine group developed incidence rate confidence interval per person years migraine group per person years non migraine group compared non migraine group crude hazard ratio migraine group multivariable adjusted hazard ratio study showed patients migraine increased risk developing
structural aerodynamic modelling dynamic stabilization three dimensional suspension bridge model considered emphasis investigating effectiveness leading trailing edge flaps suppressing aeroelastic instabilities east great belt bridge chosen design example aeroelastic limits computed using thin aerofoil theory flutter derivatives problem cast efficient reduced size finite element formulation aerodynamic forces expressed laplace domain use high fidelity rational function approximation circulatory aerodynamic forces modelled using feedback loop every element problem expressed form suitable implementation modern control techniques structure full multimodal response considered numerical predictions show good agreement experimental data literature order account modelling errors uncertainties designing controller elements robust control theory invoked stability robustness bridge fitted flaps controlled optimal suboptimal controllers discussed varying lengths control surfaces along suspended span optimum configuration aerodynamic performance investigated copyright john wiley sons ltd
purpose paper aims outline state art research contributions construction mediation domain determine whether existing research compatible future scenario envisioning wider adoption systemised use mediation construction industry develop research agenda based key challenges facing mediation design methodology approach systematic procedure based keywords adopted selection relevant research contributions area meta classification framework designed based independent classifications content method authorship analyse publications findings research contributions past decade mostly focused perceptions professionals mediation dynamics mediation process mediator tactics based challenges identified proposed research agenda includes court connected mediation mediation public projects project mediation documentation case studies mediation applications use mediation research limitations implications publications investigated study limited scholarly articles published mainstream construction management journals expanded books articles published law journals required originality value existing literature includes important contributions regarding many aspects construction mediation however holistic agenda lacking overcome key challenges widespread use mediation construction sector research directions presented paper expected contribute proliferation neglected areas constitute basis development research roadmap construction mediation domain
past earthquake liquefaction phenomenon saturated sand mixture cause severe damage various buildings structures catastrophic nature type failure obliged build structure geosynthetics used reinforce soil improve mechanical properties reinforcing elements form layers sheets waste materials soil important use practical civil engineering geotechnical applications main advantages materials locally available inexpensive recyclable waste plastics successfully used reinforcement soil improve shear strength parameters stiffness modulus paper focuses behavior plastic reinforcement sand triaxial monotonic drained conditions laboratory triaxial compression tests carried determine stress strain volumetric change behavior shear strength parameters estimate strength ratio various strain levels sand reinforced plastic layers test involved one five plastic layers placed regular vertical spacings within sand results demonstrated inclusion plastic layers increases maximum deviator stress shear strength parameters ductility maximum increase corresponding five layers plastic inclusion plastic layers reduces dilation increases strength ratio percent increase greater higher strain levels lower secant modulus measured unreinforced reinforced sand latter exhibiting higher values secant modulus axial strains tend stabilize higher values axial strain
objective analyze newly incurred injuries illnesses athletics international championships discuss risk factors design prospective recording newly occurred injuries illnesses setting european athletics championships helsinki finland participants national team local organizing committee physicians physiotherapists registered athletes main outcome measures incidence characteristics new injuries illnesses results ninety three percent athletes covered medical teams response rate one hundred thirty three injuries reported incidence injuries per registered athletes sixty two injuries resulted time loss sport common diagnosis hamstring strain injuries time loss injuries injury risk higher males increased age highest incidences injuries found combined events middle long distance events twenty seven illnesses reported illnesses per athlete days common diagnoses upper respiratory tract infection gastroenteritis diarrhea conclusions outdoor championships injury illness incidences slightly lower injury characteristics comparable outdoor world athletics champion ships elite athletics championships gender male age older years finals events combined events middle long distance races seem injury risk factors illness risk factors remain unclear previous recommendations preventive interventions focus overuse injuries hamstring strains adequate rehabilitation previous injuries decreasing risk infectious diseases transmission appropriate event scheduling sports clothes heat acclimatization
enzyme lower intensity ultrasonic irradiation leads favourable conformational changes thereby enhancing activity augmentation activity ultrasound treated enzyme strongly dependent ultrasound intensity duty cycle exposure time investigated commercial lipases thermomyces lanuginosus lipase showed fold enhanced activity irradiating khz duty cycle min ultrasonic treatment fold enhanced activity observed lipozyme candida antarctica lipase calb lipase khz duty cycle min ultrasonic treatment sonication thermodynamic parameters viz delta delta delta evaluated values found significantly lower lipases addition changes secondary structure due sonication investigated using fourier transform infrared revealed increase certain number random coiled structure loss beta sheets beta turns alpha helix content lipase calb lipase also fluorescence spectroscopy exhibited increased number tryptophan surface lipases moreover particle size distribution sonication also helped improve surface area enhanced mass transfer contributed improvement lipase activity
gender roles mainstream culture suggest girls express happiness sadness anxiety shame embarrassment boys boys express anger externalizing emotions contempt however gender roles emotion expression may different low income ethnically diverse families children parents often faced greater environmental stressors may different gender expectations study examined gender differences emotion expression low income adolescents understudied population one hundred seventy nine adolescents aged participated trier social stress test tsst trained coders rated adolescents expressions happiness sadness anxiety shame embarrassment anger contempt tsst using micro analytic coding system analyses showed consistent gender roles girls expressed higher levels happiness shame boys however contrary traditional gender roles girls showed higher levels contempt boys also contrast cultural stereotypes differences anger boys girls findings suggest gender role inconsistent displays externalizing emotions low income adolescents acute stress may reflect different emotion socialization experiences group
saving water saves energy consequently implementing integrated water management iwm measures reduce potable water consumption stormwater runoff wastewater generation potentially translate significant energy savings paper energy savings associated iwm measures rainwater harvesting gray water reuse estimated national local utility scales using published data national scale estimated paper billion kwh million potentially saved annually replacing landscape irrigation outdoor water uses rainwater harvesting alone billion kwh million combination gray water reuse similarly charlotte north carolina local water utility potentially save million kwh million annually however annual energy associated cost savings per household low either scale ranging kwh associated cost savings less results discussed terms energy savings role iwm policy considerations promotion sustainable water use urban areas american society civil engineers
article explores importance social bonds facilitating investment prosocial behavior amongst female prisoners working hiv peer educators female prisoners lack strong prosocial attachments individuals institutions prior incarceration absent bond little prevents female prisoner recidivating prison provides opportunity fashion new attachments assist reintegrative process one way create strong bonds attachment particularly women working hiv peer educator incarcerated order measure attachment levels interviews conducted female prisoners worked two hiv prison based peer programs incarceration female peers developed strong attachments one another attachments formed incarcerated maintained upon release thus serving bolster support newfound prosocial identities
optimization technique utilizes genetic algorithm used minimize electrical power produced conducting disks resistive bitter magnets resulting values optimization give conditional design parameters necessary preliminary magnet design precursor design method employed either split single solenoid nested designs method used design magnet university maryland baltimore county plasma physics research design parameters optimization used generate computer aided design models examined finite element analysis software verify safety performance design magnet design progresses series thermal mechanical tests ensure safe operating conditions
computer programming subject core ingredient engineering disciplines however first year engineering teaching learning fundamentals programming language like considered great challenge teachers novice learners challenges learning programming languages learners able analyze flow program fix errors able debug program usually dependent others problem solving bug fixing programming skills documentation important aspects software development structure program proper indentation comments proper named variables reduce general compiler errors study proposes novice way teaching language programming effective program writing skills beginners experiment conducted first year civil engineering students course computer programming based language training session effective program writing skills conducted improve ability program writing skills minimized compiler errors novice learners effect experiment verified pretest posttest training session observed program written proper indentation comments proper named variable reduce number compiler errors student written executed given programs successfully stipulated time
purpose report efficacy hydrosorb versus control water based spray topical treatment grade radiodermatitis patients pts treated early stage breast cancer normo fractionated radiotherapy patients methods pts randomized receive either hydrosorb water based spray primary endpoint local treatment failure defined interruption skin radiotoxicity change local care skin alteration secondary endpoints evaluation skin colorimetry pain quality life results two hundred seventy eight pts enrolled successfully treated pts failures hydrosorb arm control arm mostly without interruption twenty four pts stopped local care average absolute reduction colorimetric levels day day hydrosorb water spray groups respectively forty eight patients hydrosorb arm vas versus pts placebo arm respectively significant reduction pain observed hydrosorb arm conclusions present study showed significant difference hydrosorb simple water spray treatment acute radio induced dermatitis even trend improvement pain first weeks treatment systematic prevention measures modern breast cancer radiotherapy techniques allow excellent tolerability place topical treatment optimize tolerability yet defined seems important part skin care prevention skin reactions using new adapted techniques well strict hygiene elsevier ireland ltd rights reserved
evaluate consumption responses non linear medicare part prescription drug benefit compare propensity matched older patients diabetes part standard low income subsidy lis coverage evaluate monthly adherence branded oral anti diabetics high end year donut hole prices standard patients consistent low prices lis additional control examine adherence generic anti diabetics relatively low consistent prices standard patients standard patients forward looking reduce branded adherence january lis standard differences constant year contrary expectation branded adherence lower standard patients january diverges lis coverage year progresses standard lis generic adherence differences minimal findings suggest seniors chronic conditions respond myopically nonlinear part benefit reducing consumption response high deductible initial coverage gap prices thus gap fully phased cost related nonadherence likely remain face higher spot prices costly branded medications results contribute studies part plan choice medication adherence suggest seniors may make optimal healthcare decisions copyright john wiley sons ltd
many different modes chatter rolling possible causes identified years research yet clear definite theory mechanics fully established accepted two part paper stability tandem mills investigated part state space models single multi stand chatter formulated rigorous comprehensive mathematical form stability rolling system investigated sense single multi stand negative damping effects first single stand chatter model state space representation proposed coupling dynamic rolling process model structural model mill stand subsequently multi stand chatter model developed incorporating inter stand tension variations time delay effect strip transportation based single stand chatter model stability criteria proposed stability analyses performed create corresponding stability charts terms single multi stand negative damping mechanism numerical simulations particularly effect friction conditions chatter examined explanation given existence optimum friction condition part regenerative effect resulting instabilities examined suitable stability criteria mechanism established stability charts demonstrated terms relevant rolling process parameters
pediatric migraine disorder significantly interferes everyday life school life approximately children adolescents korea recently studies migraine carried rapidly many drugs developed acute phase preventive treatments migraine evaluated therefore necessary understand diagnostic criteria degree impairment pediatric migraine become familiar date treatment methods children research use botulinum toxin calcitonin gene related peptide antagonists treat adult migraine headaches progressing expect therapies applicable pediatric patients soon many students country suffering migraines daily life therefore need acquire relevant knowledge identify practical treatment methods pediatric migraine children adolescents order reduce pain
athletes sports related concussions increasingly seeking medical care management guidance return play article aims provide updated review management youth sports concussions including preseason planning field identification concussion clinical management acute concussion discussion prolonged symptoms including headache
science engineering intermingle area construction engineering works often great dimensions design life cycle many decades designed scientific basis since safety hundreds users depends design task scientific institutions define construction performance within categories correspond contemporary level knowledge technology construction appraiser speaks way ensures unquestionable competence performance elements buildings existing construction convinced scientific basis opinions comparison construction sections basic requirements presents archetype science construction matrix science construction reveals multi faceted nature related time issue durability considered related scale complexity defining construction performance terms technical features constant search relationship material model usability model building construction industry uses lot rules thumb sector technology era computer aided design cad building information modelling bim rules thumb remain invaluable verification tools
topology recognition leader election fundamental tasks distributed computing networks first requires node find labeled isomorphic copy network result second one consists single node adopting label leader nodes adopting label learning path leader consider problems networks whose nodes equipped necessarily distinct labels called colors ports node degree arbitrarily numbered colored networks generalizations labeled networks nodes distinct labels anonymous networks nodes labels nodes color colored networks topology recognition leader election always feasible hence study two general problems consider colored network input given nodes aim problem top colored network solve topology recognition network possible input nodes answer unsolvable otherwise likewise aim problem solve leader election network possible input nodes answer unsolvable otherwise show nodes network solve problems top given input upper bound number nodes given color called size color hand show nodes given input bound size color answer top must unsolvable even class rings assumption nodes given upper bound size given color study time solving problems top local model round node exchange arbitrary messages neighbors perform arbitrary local computations give algorithm solve problems arbitrary networks time log diameter network size also show time optimal exhibiting classes networks every algorithm solving problems top must use time omega log elsevier rights reserved
novel global pid control scheme nonlinear mimo systems proposed implemented robot study case scheme called awfpid adaptive wavelet fuzzy pid control structure basically identifies inverse error dynamics using radial basis neural network daughter rasp wavelets activation function output cascaded infinite impulse response iir filter prune irrelevant signals nodes well recover canonical form online adaptive fuzzy tuning discrete pid regulator proposed whose closed loop guarantees global regulation nonlinear dynamical plants wavelet network includes fuzzy inference system online tuning learning rates real time experimental study three degrees freedom haptic interface phantom premium highlights regulation smooth control effort without using mathematical model robot elsevier rights reserved
paper validated numerical model describing heat transfer air flow phenomena bldc motor presented validation performed using results multiple velocity temperature measurements air velocity measured constant temperature anemometers cta using laser doppler anemometry lda outside inside motor casing respectively temperature measurements conducted involving thermocouples located stator winding internal external casing walls surrounding air numerical experimental results satisfactory agreement
first wall demo component high thermal loads cooling comply material upper lower temperature limits requirements stress assessment like low temperature gradients also cooling integrated balance plant sense deliver exergy power cycle require limited pumping power coolant circulation paper deals basics cooling proposes optimization approaches effectiveness several heat transfer enhancement techniques investigated use helium cooled designs demo among wall mounted ribs large scale mixing devices modified hydraulic diameter performance assessed computational fluid dynamics cfd heat transfer coefficients pressure drop compared based results extrapolation high heat fluxes tried estimate higher limits cooling capabilities karlsruhe institute technology published elsevier rights reserved
prediction shape memory behavior essential regarding design smart material different applications paper proposes simple quick method prediction shape memory behavior amorphous shape memory polymers smps basis single dynamic mechanical analysis dma temperature sweep constant frequency parameters constitutive equations linear viscoelasticity obtained fitting dma curves change temperature time temperature superposition shift factor expressed williams landel ferry wlf model near glass transition temperature arrhenius law constants wlf arrhenius equations also determined results calculations agree satisfactorily experimental free recovery curves shape memory tests
background prevalence asthma industrialized countries increasing dramatically asthma common chronic disease children united states rapidity increase strongly suggests changes environmental exposures likely cause epidemic early onset allergic manifestations suggests exposures may act prenatal development immune system focused potential effects bisphenol bpa chemical pollutant one largest productions development childhood asthma reported perinatal bpa exposure promotes development allergic asthma mouse model current study designed identify critical period bpa exposure begin elucidating mechanisms susceptibility methods female balb mice received micro bpa drinking water one week pregnancy end study pups transferred first life bpaloaded mother unexposed mother vice versa half pups sensitized low dose experimental allergen ovalbumin ova rest received pbs unsensitized controls day pups challenged inhalations ovalbumin pbs followed quantification eosinophils hyperreactivity airways major indicators experimental asthma classical mouse model hepatic expression two isoforms udp glucuronosyltransferase ugt quantified quantitative pcr various ages results pups exposed bpa utero breast milk utero displayed asthma phenotype response suboptimal allergic sensitization whereas pups exposed bpa postnatally breast milk expression ugtb isoform related bpa clearance rats detectable mouse fetuses newborn pups increased day approached adult levels day conclusions prenatal exposures produce environmentally relevant burdens bpa followed postnatal allergic sensitization challenges promote development experimental allergic asthma delayed expression bpa metabolizing enzymes may explain least part enhanced fetal susceptibility common environmental contaminant
present study aimed investigate synergistic therapeutic effect decreaseing cartilage angiogenesis via exposure crizotinib encapsulated chitosan microspheres photo crosslinked hydrogel goal evaluating crizotinib treatment osteoarthritis first developed evaluated characteristics hydrogels chitosan microspheres next measured effect crizotinib cartilage degeneration induced interleukin beta chondrocytes crizotinib ameliorated pathological changes induced interleukin beta via anti angiogenesis function addition surgically induced osteoarthritis mice injected intraarticularly crizotinib loaded biomaterials cartilage matrix degradation expression vascular endothelial growth factor extracellular signal regulated kinases evaluated surgery treatment combination crizotinib loaded biomaterials retarded progression surgically induced osteoarthritis crizotinib ameliorated cartilage matrix degradation promoting anti angiogenesis impeding extracellular signal regulated kinases signaling pathway results demonstrate combination photo crosslinked hydrogel crizotinib loaded chitosan microspheres might represent promising strategy osteoarthritis treatment
national institute technology nit kurukshetra acre campus residents campus due lack efficient drainage system campus turns system pools important locations accumulation water long durations creates unhealthy environment inhabitants besides damaging roads pavement foundation buildings hence keeping view problems status campus rainwater harvesting considered one solutions addressing problem accumulated rainwater nit kurukshetra total area campus sqm sqm built area rest plain area utilized artificial recharge paper efficient design rainwater harvesting system campus proposed detailed design components rainwater harvesting artificial recharge filter gallery recharge well recharge pit inspection pit etc provided expected result study implemented certainly fulfill dual objective addressing menace water logging campus besides enriching groundwater aquifer authors published elsevier ltd
zinc finger protein type like zfpl member tristetraprolin ttp family role aging related bone loss currently unknown present evidence zfpl expression rat femurs bone marrow mesenchymal stem cells bmmscs regulated aging zfpl knockdown decreased osteoblastic differentiation mct cht cells increased adipogenic differentiation cht cells whereas zfpl overexpression opposite finding zfpl overexpression enhanced osteoblastic repressed adipogenic differentiation also corroborated vivo experiments troglitazone prevented zfpl inhibiting adipogenic differentiation suggesting significance ppar gamma repression zfpl inhibitory effect adipogenic differentiation zfpl overexpression repressed expression ppar gamma mrna ppar promoter activity biotin pull electrophoretic mobility shift assays suggested zfpl might interact endogenous ppar gamma mrna binding utr zfpl containing ribonucleoprotein complexes zfpl overexpressing cells contained less ppar gamma mrna control cells luciferase reporter construct replacement poly fragment utr ppar gamma mrna reduced expression luciferase transcripts zfpl overexpressing cells examination kinetic expression ppar gamma mrna transcriptional blockage showed zfpl might enhance degradation transcripts together data imply zfpl overexpression might repress adipogenesis least regulating ppar gamma expression post transcriptional mechanisms thus findings support notion decrease zfpl expression bmmscs aging might contribute aging related bone loss
industry corner introduction developer chronic asthma child built first leed leadership energy environmental design platinum certified apartment complex idaho also heard two residents asthma longer resulted attacks due eliminating triggers interior environment eight years dozen multifamily affordable housing projects later leed consultant projects gathered insight best practices lessons learned strategies result resident owner project team satisfaction ten projects achieved leed platinum certification two still construction track platinum home energy rating system scores low feedback collected works matters low energy bills living healthy home asthma attacks projects debunk assumptions energy efficiency adds much cost green homes wealthy
background little available data carotid femoral pulse wave velocity pwv subjects subclinical hypothyroidism sch aimed analyze association sch pwv using baseline data brazilian longitudinal study adult health elsa brasil methods included subjects normal thyroid function thyrotropin tsh miu normal free thyroxine sch tsh miu normal evaluated pwv crosssectional analysis excluded individuals using medications interfere thyroid function antihypertensives diuretics subjects chronic kidney disease previous cardiovascular disease generalized linear logistic regression models evaluated pwv dependent variable sch independent variable adjusted cardiovascular risk factors results subjects women euthyroid showed sch median age years interquartile range groups differed age sex body mass index glomerular filtration rate reactive protein sch associated pwv full adjusted linear model beta pwv percentile full adjusted logistic model odds ratio confidence interval conclusion large sample sch associated increased pwv
combined sewer overflow cso infrastructure conventionally designed based historical climate data yet variability rainfall intensities patterns caused climate change significant impact performance urban drainage system although rainwater harvesting rwh potential solution manage stormwater urban areas benefits mitigating climate change impacts combined sewer networks assessed yet hence goal present study set evaluate effectiveness rwh alleviating potential impacts climate change csos first future rainfall achieved coupled model intercomparison project phase cmip based modified historical record rainfall runoff modeling employed using epa stormwater management model swmm study response cso outfalls future rainfall study site combined sewer network city toledo ohio results showed maximum impact scenario near future climate change might cause approximately increase csos occurrence volume duration toledo however rwh plan capacity gal implemented half buildings throughout area appeared able mitigate potential future impacts showed remarkable controlling performance peak flow periods plan also met toilet flushing demands therefore rwh considered feasible solution mitigate future climate change impacts csos supply water demands elsevier ltd rights reserved
benefits deep green renovations speak moment number deep green renovations grown significantly results shown variety benefits deep renovations health wellbeing perspective well economical perspective yet looking existing building landscape vast majority buildings baltic countries well europe renovated deeply renovated reached reach end expected lifetime multi apartment stock accounts largest share existing building stock terms number inhabitants well square footage example riga largest share multi apartment buildings million square meters built years ago taking account multi apartment buildings built last years even less complex renovations crucial order continue exploitation stock large scale renovations uptake using structural funds private sector financing also opens room innovation improvements existing building stock building sector general order attract investments logical building sector system required deep green renovations help shaping system improving existing practices four key elements implementation deep green renovation practices national regional levels policy regulation finance economics skills capacity building overall awareness paper discusses potential elements looks best existing practices one key challenges identifying successful practices impact data collection meaning many initiatives expected impact estimated measures evaluate actual results taken additionally paper discusses necessary connections elements order reach quickest possible result rapid improvements existing building stock hypothesis states finance deep green renovations flow society asks quality renovations enough skilled specialists place carry different works deep renovation process legislation progress driven innovation enabling however conclusions state awareness society umbrella process needs continuous improvement various forums continuous advocacy ensure development processes related authors published elsevier ltd
paramedics health care workers assess manage health concerns prehospital setting increasingly providing psychosocial care response rise mental health call volume observers construed fact misuse paramedic services proposed solutions better triaging patients better mental health training paramedics greater number community mental health services commentary argue despite ostensibly well intentioned nature solutions shift attention accountability away relevant public policies well broader economic social political determinants mental health placing responsibility requiring services best health care system also argue perspective paramedics exposed interact individuals everyday environments potential inform better structural critical understanding factors driving rise psychosocial crises first place finally suggest greater engagement political social determinants mental health would lead preventing rather primarily reacting crises fact
background study aimed identify important factors changing pattern drug abuse opium methamphetamine iranian drugdependent women materials methods study phenomenological study data analyzed step colaizzi method subjects selected patients referred addiction rehabilitation residential center welfare organization bojnurd city located northeast iran results found conceptual classes codes analysis data individual factors follow elevation mood obtaining pleasure increasing energy improving performance relief physical pain sensation seeking conclusions depth review analyses interviews revealed individual factors important factor crystal meth abuse
argentina campaigns recognition sexual reproductive rights sparked opposition litigation dynamics legal action come self proclaimed pro life ngo particularly since conservative ngo portal belen successfully achieved banning emergency contraception courts activities groups acting civil arm religion focused primarily obstructing access legally permissible abortions bringing withdrawal number recognized public policies sexual reproductive health particularly national programme sexual health responsible procreation paper analyzes litigation strategies conservative ngos use courts argentina changed years gives examples efforts local courts block individual young women accessing legal abortion following rape despite ruling national supreme court justice judicial permission required spite major advances renewed influence catholic hierarchy argentine political scene accession new pope poses challenges work feminists women movements extend consolidate sexual reproductive rights reproductive health matters
largest volcanic constructs earth seismically imaged seaward dipping reflector sdr units found offshore many rifted continental margins including border atlantic ocean whether formation requires large magnitude normal fault slip results deflection lithosphere weight volcanic flows controversial though evidence faulting associated sdrs paper considers range structures produced magmatic volcanic loading alone idealized mechanical model construction rift related volcanic flow structures developed dikes open plates move away center model rift volcanic flows fill depression produced load caused dike solidification thin elastic plate flexure approximation allows closed form description shape contacts flows flows underlying dikes model depends two independent parameters flexure parameter alpha maximum isostatically supported extrusive layer thickness reasonable values parameters model reproduces observed dip thickening flows range reflector dip angles numerical scheme using analytic results allows simulation effect temporal changes locus magmatic spreading well changes amount volcanic infill either jumps location center diking periods volcanism result separate units packages model sdrs flow dike contact dips landward consistent observations previously attributed listric normal fault offset jumps spreading center small less result thicker narrower volcanic units one side rift compared side similar asymmetric distributions volcanic packages seen across conjugate margins elsevier rights reserved
nonlinear response light bistability ikeda instability dynamics light within ingaaspinp modified add drop resonator panda vernier resonator studied signal flow graph method used obtain optical transfer function invariant symmetric coupling coefficients indirect couplers applied effect changing symmetric direct couplers two different resonant mode numbers studied minimum drop port switching time resonant mode numbers achieved respectively simulated results introduce panda vernier system proper optical device future optical communication signal processing systems
background ilrn mutation identified one pathogenesis generalized pustular psoriasis existence gpp patients without mutation makes controversial objective study aimed assessing differences clinical profiles children gpp without ilrn mutation methods ambispective case series study involved review records childhood patients pediatric onset gpp without previous psoriasis vulgaris results common mutation chinese population gpp alone age onset nearly halved homozygotes compound heterozygotes ilrn negative patients besides severe inflammatory progression three minor signs could prioritize patients gpp ilrn screening confluent lakes pus perianal erosion flexural erosion patients pathogenic mutation converted ach without mutation chi children gpp without ilrn mutation responded well oral low dose acitretin ilrn positive cases suffered much higher half year recurrence rate withdrawl acitretin treatment chi conclusions specific clinical features remind dermatologists necessity sequencing diagnosis mild pustular phenotype without mutation may imply possible role epigenetic changes ilrn blockers pathogenesis pediatric patients gpp alone without ilrn mutation responded well low dose acitretin japanese society investigative dermatology published elsevier ireland ltd rights reserved
goal study propose computer aided diagnosis system differentiate four breast imaging reporting data system rads classes digitised mammograms system inspired approach doctor radiologic examination agreed rads masses described form boundary density segmentation masses authors approach manual supposed detection already made segmented region available features extraction process carried visual characteristics automatically computed shape edge textural properties one human feature used study patient age classification finally done using multi layer perceptron according two separate schemes first one consists classify masses distinguish four rads classes second one authors classify abnormalities two classes benign malign proposed approach evaluated mammographic masses extracted digital database screening mammography obtained results encouraging
objective describe trend indirect standardized death rate hiv different modes hiv transmission puerto rico estimate magnitude association mode hiv transmission mortality different time periods puerto rico methods isdrs sex mode transmission computed using data national hiv aids surveillance system poisson models used assess annual percent change isdrs rrs sex results injection drug users idus showed highest decrease isdr men women compared men sex men msm idu men also highest representing increase rridu msm compared women idus heterosexual het women less risk dying period conclusion mortality decreasing mode transmission sexes addition though idus present highest decrease isdr still group whose members highest risk dying men women better describe health disparities related hiv aids mortality future analyses performed using specific causes death evaluation relevant clinical sociodemographic factors data might increase understanding mortality people hiv aids island well help future efforts develop intervention strategies aforementioned risk groups
introduction atrial fibrillation cardiac arrhythmia caused various mechanisms multiple reentering wavelets high frequency activity rotor sources evidence acquisition narrative review based papers found pubmed medline may search terms atrial fibrillation combination catheter ablation pathophysiology antiarrhythmic drugs evidence synthesis antiarrhythmic drugs cornerstone therapy efficacy safety might improved case failure pharmacologic therapies treatments considered better understanding important role pulmonary veins led new approaches ablation procedures initially surgical percutaneous options later added however strategies may present various technical complications also performed skilled operators promising field investigation genetics highlighted studies role micro rna conclusions relevant improvement knowledge electrophysiological basis genesis maintenance done order treat common arrhythmia studies genetics field open new challenging therapeutic horizons
study geometric topological properties image smooth submanifold lipschitz map particular characterize dimension diameter volume reach embedded manifold relate original main result establishes lower bound reach embedded manifold case lipschitz map linear discuss implications work signal processing machine learning lipschitz maps low dimensional manifolds constructed using randomized linear operators
four dimensional infinite impulse response frequency hyper planar filter digital vlsi architecture real time light field based depth filtering applications proposed signal flow graph based discrete spatial integrators introduced leads improved sensitivity properties perturbations filter coefficients first order sensitivity analysis filter transfer function shows reduction maximum gain error frequency response bits fractional precision compared direct form architecture prototype fpga hardware loop simulations performed two different light field geometries register transfer level design validation carried via fpga hardware emulation host computer providing memory buffers full design emulation carried standalone berkely emulation engine bee operating mhz two light field geometries respectively cmos implementation carried synthesis level yielding operating frequencies mhz correspondingly frame rates two light field geometries respectively
objectives population survey conducted urban shantytown bangladesh baseline study future epidemiological studies paper aims describe findings study including population profile residential environment urban poor methods conducted complete count household survey urban poor community dhaka using brief structured questionnaire bengali language trained interviewers visited household asked questions duration residence ownership house toilet kitchen water supply number family members age sex education occupation tobacco use history diseases family member results found households people community average number household members people access safe water lived house toilet based proxy indicators household wealth levels identified relatively well rest poor tobacco use prevalent men regardless age women aged years prevalence self reported hypertension diabetes slightly higher women men although respondents know diseases incidences diarrhea last one month relatively low conclusions study showed population profile sanitation environment urban poor community complete count survey expect study serve baseline future epidemiological studies
control method improving tracking performance respect reference trajectory developed proposed control system inner outer control structure inner control system existing control system based conventional pid controller designed advance independent outer control system order improve tracking performance outer control system designed based optimal preview control theory added outside inner control system polynomial trajectory used reference trajectory fed outer control system reference trajectory modified online minimize tracking error modified reference trajectory derived control input signal outer control system fed inner control system effectiveness proposed control method confirmed using numerical simulations benchmark problem hard disk drives hdds
objectives almost half pregnancies united states unintended pregnancies associated adverse outcomes many reproductive age females seek care emergency department risk pregnancy amenable contraceptive services setting pilot study sought assess providers current practices attitudes knowledge emergency contraception nonemergency contraception non well barriers respect contraception initiation methods physicians associate providers georgia mailed link anonymous internet questionnaire using state professional databases contacts questionnaire included likert scales multiple choice questions assess study objectives descriptive statistics generated well univariate analyses using fisher exact tests results total providers mailed questionnaires completed participants predominantly physicians men individuals younger years common practices referrals prescriptions non prescriptions common barriers perceived low likelihood follow risk complications adverse effects participants correctly identified highly effective contraceptive methods identified correct maximum initiation time correctly recognized pregnancy higher risk hormonal contraception use pulmonary embolism conclusions providers pilot study referred patients contraception however universal contraceptive counseling management many providers study incorrect understanding efficacy risks eligibility associated contraceptive methods lack understanding may affect patient access barrier patient care
paper surveys selected state space robust control methods suitable implementation motion systems implementation laboratory plant modular servosystem robust control theory taught within control engineering courses msc study program applied mechatronics robust methods algorithms developed verified control engineering laboratory solution student research projects project based learning suitable laboratory plants well established method control engineering education mechatronics ifac international federation antomatic control hosting elsevier ltd rights reserved
study investigates agreement leaders team perceptions influence intervention outcomes leadership training intervention aimed improving organizational learning agreement perceptual distance calculated organizational learning dimensions baseline changes dimensions pre intervention post intervention evaluated using polynomial regression analysis response surface analysis general pattern results indicated organizational learning improved leaders teams agreed level organizational learning prior intervention improvement greatest leader team perceptions baseline aligned high rather aligned low least beneficial scenario leader perceptions higher team perceptions results give insights importance comparing leaders team perceptions intervention research polynomial regression analyses response surface methodology allow three dimensional examination relationship two predictor variables outcome contributes knowledge combination predictor variables may affect outcome allows studies potential non linearity relating outcome future studies could use methods process evaluation interventions copyright john wiley sons ltd
ghz uwb radar chip cmos process presented paper uwb radar transceiver surveillance biometric applications adopts equivalent time sampling architecture channel time interleaved samplers relax impractical sampling frequency enhance overall scanning time front end rffe includes wideband lna way power splitter analog signal processing part consists high speed track hold sample hold integrator interleaved timing clocks generated using delay locked loop uwb transmitter employs digitally synthesized topology measured rffe ghz dll timing resolution measured spectrum uwb transmitter shows center frequency within ghz satisfying fcc spectrum mask power consumption receiver transmitter supply respectively
paper introduces hand gesture recognition sensor using ultra wideband impulse signals reflected hand reflected waveforms time domain determined reflection surface target thus every gesture reflected waveform thus propose use machine learning convolutional neural network cnn gesture classification cnn extracts feature constructs classification model classifies reflected waveforms six hand gestures american sign language asl used experiment result shows recognition accuracy fine movements rotating plaster model measured degrees step average recognition accuracy also
newborns exceedingly susceptible infection however little known governs immunological differences seen early life result extreme vulnerability infection changes infancy herein provide evidence reduced ability mount protective immune response pathogens due inherent immaturity neonatal immune cells instead functions immune cells actively suppressed erythroid cells furthermore role erythroid cells host defense infection examined erythroid cells enriched newborns distinctive immunosuppressive properties leave vulnerable infection moreover immature erythroid cells possess exclusive immunomodulatory properties may play role immune ontogeny addition distinct features erythroid cells impact digestive health preventing excessive inflammation following sudden transition sterile utero setting excessive colonization commensals external environment ongoing research identifying beneficial detrimental effects immature erythrocytes immune responses may serve enhance protective newborn immune responses infection enable better vaccination strategies young designed
hand wrist injuries athletes common representing sports injuries many quarter sports injuries involve hand wrist review recent literature regarding acute hand injuries athletes based structures involved bone muscle tendon ligament neurovascular including diagnosis pathophysiology injuries focusing athlete specific facets treatment available opinions return play
recent years diagnosis electric motors appealed increasingly signal processing methods develop methods necessary reliable mathematical model physical signal processed case signal stator current unfortunately often stator current obtained expensive measurement bench complex modelling electric motor aim paper model induction motor stator current presence rotor fault diagnose model must take account effects presence fault fact presence rotor fault manifested eccentricity air gap oscillation load torque causes amplitude phase modulations current purpose impact severity rotor fault two types modulations expressed studied mathematical model also demonstrated paper work
aimsto explore common effects clusterin clu variant default mode network dmn amnestic mild cognitive impairment amci subjects remitted geriatric depression rgd subjects methodsfifty one amci subjects rgd subjects cognitively normal elderly subjects underwent resting state fmri scans neuropsychological tests baseline month follow posterior cingulate cortex seed based functional connectivity analysis used obtain dmn patterns resultsa clu genexdiseasextime interaction amci subjects mainly detected core cortical midline structures dmn interaction rgd subjects mainly detected limbic system however overlapped two frontal regions consistent effects clu gene alterations found amci rgd groups furthermore alterations frontal parietal limbic regions compensated episodic memory impairments clu carriers compensation found clu carriers conclusionthe clu gene could consistently affect dmn frontal regions among individuals risk alzheimer disease clu allele associated compensatory neural processes dmn changes
health care systems around world facing increasing costs non adherent chronically ill patients one expense incurred health care providers web based home monitoring patients ehealth shown increase adherence medical therapy facilitate contact patients health care professionals reduce time remission patients inflammatory bowel disease ibd web based treatment supportive tool health care provider patient clinic ehealth web programs constant care application visualize disease activity traffic light system empower patients screen disease activity enabling respond appropriately symptoms ehealth screening procedure monitoring pediatric adult ibd patients based self obtained symptom score together fecal biomarker inflammation fecal calprotectin patients measure independently using smart phone providing patient physician immediate disease status react instantaneously likewise web applications ibd patients web applications irritable bowel syndrome ibs patients also ibd patients existing ibs proven valuable monitoring treating ibs symptoms diet low fermentable oligo monosaccharides polyols low fodmap diet careful disease monitoring via web application increased patient adherence ehealth might capable improving natural disease course ibd ibs
recent years gene network modeling gaining popularity genomics monitor activity profile genes specifically objective network modeling concept study genetic behavior associated disease previous researchers designed network model nucleotide level produces complexity designing circuits mostly case gene expression studies whereas authors designed present network model based amino acid level simpler well appropriate prediction genetic abnormality present concept siso continuous discrete system models genes realized using foster network model designed based hydropathy index value amino acids study biological system behavior time phase response continuous domain pole zero distribution discrete domain used measurement metric present study simulated responses system show genetic instability cancer genes truly reflects medical reports proposed modeling concept used accurately identify separate diseased genes healthy genes elsevier rights reserved
research sustainable structural design ssd increased significantly past decade established importance structural engineering sustainable development researchers practitioners developed sustainable design strategies address impact structural systems environment economy society nevertheless many studies pointed inadequacy existing assessment tools lack overall understanding regarding role civil engineers structural engineers achieving sustainable goals purpose paper provide comprehensive state art overview ssd focusing design strategies parameters ssd role ssd green building rating systems building codes first authors clearly identify research results field point biggest issues choosing ssd strategies evaluation parameters conclude paper discuss characteristic tasks structural engineers particular emphasis concepts structural performances design service life probabilistic approach
comprehensive psychiatric rehabilitation programs latin america designed across several countries region without yet achieving full implementation facing increasing burden disease due mental disorders including alcohol substance use disorders region responded unevenly challenge moreover low priority mental health national policies insufficient funding mental health services common barriers much needed mental health services reforms reestablishing primary care community based model care shared aspiration countries last two decades comprehensive models psychiatric rehabilitation developed predominantly high income countries need culturally adapted local contexts strengthening health systems research provide evidence efficiency locally designed interventions critical milestones succeed scaling strategies increasing participation patients families mental health delivery system another key factor order ensure comprehensive patient centred psychosocial rehabilitation programs latin america
echinacea pallida epal herbaceous flowering plant immunomodulatory properties chosen determine pre post supplementary effects growth performances bacterial community blood parameters immunity growing rabbits grimaud week old studied first part study randomly divided two groups group first group fed basal diet without supplementation control group another group fed basal diet supplemented epal diet echinacea group second parturition weaned kits randomly assigned four groups animals fed growing commercial diet supplemented without epal diet group rabbits fed control diet group rabbits fed supplemented diet rabbits fed control diet group rabbits fed supplemented diet dietary epal treatment affect growth performance ten fattening rabbits group selected evaluate bacterial community blood parameters remaining rabbits group used study phagocytosis humoral immune response variability evaluated hard faeces days caecal content days variability bacterial community group higher groups phagocytic activity higher groups ones whereas statistically significant difference observed blood parameters humoral immune response vaccination rabbit haemorrhagic disease virus days old serum collected days old conclusion impact epal dietary supplementation observed growth performances bacterial community blood parameters humoral immune responses growing rabbits except increase phagocytic activities
suicide major cause death throughout world recent studies proved reliable connection emotional traits suicide however detection prevention suicide mostly carried clinical centers limit effective treatments restricted group people assist detecting suicide risks among public propose novel method exploring accumulated emotional information people daily writings blogs examining emotional traits predictive suicidal behaviors complex emotion topic model employed detect underlying emotions emotion related topics blog streams based eight basic emotion categories five levels emotion intensities since suicide caused accumulative process propose three accumulative emotional traits accumulation covariance transition consecutive blog emotions employ generalized linear regression algorithm examine relationship emotional traits suicide risk experiment results suggest emotion transition trait turns discriminative suicide risk combination three traits linear regression would generate even discriminative predictions classification suicide nonsuicide blog articles additional experiment verifies result finally conduct case study commonly mentioned emotion related topics suicidal blogs understand association emotions thoughts authors
study proposes model predictive control mpc onboard ultracapacitors light rail vehicles using maximum current constraint study kalman filter used estimate system states compared pid controller mpc based charging control strategy solve maximum current limit problem converts charging problem optimization one simulation experiments carried demonstrate effectiveness method
recent reports tree mortality associated anomalous drought heat raised interest processes underlying tree resistance resilience water stress hydraulic failure carbon starvation proposed main causes tree decline recent theories treating water carbon metabolism interconnected processes subjected young plants two native quercus pubescens prunus mahaleb two invasive robinia pseudoacacia ailanthus altissima woody angiosperms prolonged drought leading stomatal closure xylem embolism induce carbon starvation hydraulic failure end treatment plants measured embolism rates nsc content irrigated monitor recovery xylem hydraulics data highlight different hydraulic strategies native invasive species water stress provide physiological explanations species specific impacts recent severe droughts drought sensitive species suffered high embolism rates unable completely refill xylem conduits upon restoration water availability species better survived recent droughts able limit embolism build efficiently restored hydraulic functionality irrigation species specific capacity reverse xylem embolism correlated stem level concentration soluble carbohydrates starch content elsevier masson sas rights reserved
certain studies suggested tumor necrosis factor alpha tnf alpha polymorphism associated risk ankylosing spondylitis however conclusions remain controversial therefore performed meta analysis provide precise conclusion databases pubmed embase cbm cnki wanfang data searched identify relevant studies august odds ratios ors confidence intervals cis used estimate association tnf alpha polymorphism ankylosing spondylitis susceptibility total studies included meta analysis overall elevated risk tnf alpha polymorphism ankylosing spondylitis observed three genetic model except homozygote model recessive model sensitivity analysis showed overall results robust subgroup analyses according hardy weinberg equilibrium ethnicity showed increased risk ankylosing spondylitis predominant asian population meta analysis indicated tnf alpha polymorphism might increase susceptibility ankylosing spondylitis especially asians studies needed verify conclusion
organic rich mudrock systems play important role world volatile petroleum industry due complex pore structures large portion nano pores flow mechanics gas flow pore space may involve nanoscale effects could accounted classic darcy law also difficult experimentally probe transport properties extremely low permeability rock samples digital rock physics drp obtains direct view internal structure reservoir rock sample digitized high resolution images compute properties porosity directional permeability hence enable studies multi scale flow mechanics mudrocks study present parallel lattice boltzmann method plbm studying nanoscale effects three dimensional tube flow simulate flow process gas flow real pore geometry two perpendicularly cored mudrock samples combining image processing methods drp pore geometry obtained digital image data based ultra high resolution ray computed tomography xct imaging numerical advantages lattice boltzmann method lbm make powerful tool simulate gas flow nano pores estimate absolute permeability new parallel implementation successfully performed powerful high performance computing cluster hpcc validated analytical solution tube flow model taken elementary model pore networks simulating nanoscale effects rarefaction slippage roughness gas flow nano tube model propose realistic parameters simulating gas flow real mudrocks study flow mechanics calculate apparent directional permeability results show simulated porosities close measured porosities estimated apparent permeability close measured permeability apparent directional permeability able estimated identified pores subsamples connected direction image resolution voxel permeability anisotropy clearly observed velocity field visualization calculated permeability values characteristics pore geometry flow velocity distribution transport properties captured using drp plbm effective way simulate complex gas flow kerogen pores estimate apparent directional permeability elsevier rights reserved
fetal postnatal phenotype influenced developmental conditions experienced prenatally among prenatal development metabolic factors particular importance supposed predispose pathophysiological alterations later life pioneer functional impairment senescence metabolic programming till mechanisms metabolic programming well understood investigated various concentrations glucose differentiation pluripotent embryonic carcinoma cells ecc cardiomyocytes undifferentiated cells exposed low control high glucose embryoid body formation followed plating differentiation cardiomyocytes vitro standard glucose supplementation days amount cardiac clusters frequency spontaneous beatings well expression metabolic cardiac marker genes promoter methylation measured observed metabolic programming effect glucose cardiac differentiation whereas number beating clusters expression cardiac marker alpha myosin heavy chain alpha mhc comparable groups frequencies beating clusters significantly higher high glucose group compared low glucose however neither insulin receptor insulin like growth factor receptor igfr metabolic gene glucose transporter glut influenced rna expression promoter methylation data indicate short time glucose stress embryonic cell determination leads lasting effects terminally differentiated cell function elsevier inc rights reserved
mechanical manufacturing engineering important professional basic course degree course mechanical design manufacturing automation important position outstanding engineers training program problems existed present course teaching mechanical manufacturing engineering detailed analyzed paper explored constructing teaching curriculum system teaching contents teaching outstanding engineers training reforming old outdated teaching methods means reformation results show students learning enthusiasm initiative improved engineering consciousness innovation ability greatly improved
two algorithms allow one take uneven road surface account vehicle dynamics analysis presented article essence determine position contact point tire model uneven road surface according concept authors names algorithms refer essence matter procedures assumed first named plane used considering continuous model surface obtained use bicubic interpolation taken computer graphics second one named points case discrete model surface developed especially needs methods presented work assumed continuous changes road profile without possible abrupt changes form transversely placed threshold sharp edges considered therefore mapping road surface obtained case including models smooth developed algorithms used analyze dynamics technical rescue vehicle drive terrain conditions
rationaledecision making performance assessments proven problematic assessing clinical reasoning aims objectivesa bayesian approach designing advanced clinical reasoning assessment well grounded mathematical cognitive theory may offer significant psychometric advantages probabilistic logic plays important role medical problem solving performances bayesian type tasks appear causally related ability make sound clinical decisions methodsa validity argument used guide design assessment medical reasoning using clinical probabilities results conclusionsthe practical advantage using bayesian approach item design relates fact probability theory provides rationally optimal method managing uncertain information provides criteria objective correct answer scoring potential item formats discussed
humans help attribute human emotions non human animals although attributions often regarded gratuitous anthropomorphisms held apart attributions humans make internal states may product general mechanism flexibly interpreting adaptive behavior examine used functional magnetic resonance imaging fmri humans compare neural mechanisms associated attributing emotions humans non human animal behavior although undergoing fmri participants first passively observed facial displays human non human primate domestic dogs subsequently judged acceptability emotional annoyed facial descriptions baring teeth images targets emotion attributions selectively activated regions prefrontal anterior temporal cortices associated causal explanation prior studies regions similarly activated human non human targets even passive observation task moreover degree neural similarity dependent participants self reported beliefs mental capacities non human animals results encourage non anthropocentric view emotion understanding one treats idea animals emotions gratuitous idea humans
hereditary angioedema hae rare autosomal dominant genetic disorder clinically characterized recurrent attacks subcutaneous mucosal swelling result significant morbidity even mortality several novel therapies introduced since dramatically transformed approach management review discuss current understanding pathophysiology hae diagnostic evaluation recurrent angioedema without urticaria therapeutic approach hae advocate taking integrative approach care order normalize lives affected patients
network security quality service qos consume computational resource system thus may evidently affect application services case limited computational resource important model mutual influence network security qos concurrently optimized order provide better performance available computational resource paper evaluation model accordingly presented describe mutual influence network security qos multi objective genetic algorithm nsga revised optimize multi objective model using intrinsic information target problem new crossover approach designed enhance optimization performance simulation results validate algorithm find set pareto optimal security policies different network workloads provided potential users differentiated security preferences obtained pareto optimal security policies meet security requirement user also provide optimal qos available computational resource elsevier ltd rights reserved
linear programming optimization widely used several application areas one possible application optimization technique received sufficient attention process control particular standard structure linear programming optimization problems allows formulating optimal predictive control schemes additional advantage facilitating handling actuator saturation actuator saturation appears many engineering applications several control approaches dealing problem article simple predictive control scheme based linear programming optimization actuator saturation control proposed main characteristics presented scheme simplicity practical robustness performance tuning parameters first simplest possible output feedback linear programming predictive controller proposed starting point next several practical observations inspired classical control engineering series modifications basic controller structure proposed modifications aim effectively increasing performance robustness control algorithm experimental results confirm proposed control algorithm operate effectively presence perturbations something currently widely reported literature linear programming actuator saturation predictive control
familial hemiplegic migraine type fhm rare monogenic subtype migraine aura caused mutations cacnaa encodes alpha subunit voltage gated calcium channels transgenic knock mice carry human fhm missense mutation fhm mice exhibit increased susceptibility cortical spreading depression csd mechanism underlying migraine aura analysed gene expression profiles isolated cortical tissue fhm mice experimentally induced csd order identify molecular pathways affected csd gene expression profiles generated using deep serial analysis gene expression sequencing data reveal signature inflammatory signalling upon csd cortex mutant wild type mice however brains fhm mice specific genes regulated response csd implicated interferon related inflammatory signalling findings show csd modulates inflammatory processes wild type mutant brains additional unique inflammatory signature becomes expressed csd relevant mouse model migraine
background vasohibin vash previously identified agiogenenic factor cancer related protein investigated association vash expression chemoresistance pancreatic cancer methods immunohistochemical staining vash performed human pancreatic cancer samples pancreatic cancer cell line models exhibiting overexpression knockdown vash generated gene expression analyses carried determine genes differentially regulated vash putative transcription factors downstream mediators gene expression regulated vash queried bioinformatically dual luciferase reporter assays chip assays performed confirm transactivation target genes following vash overexpression knockdown results vash protein expression higher human pancreatic cancer paired adjacent tissues elevated vash levels associated gemcitabine chemoresistance cell line models pancreatic cancer vash expression induced gemcitabine chemoresistance vitro vivo discovered expression ribonucleotide reductase regulatory subunit rrm regulated vash immunohistochemical analysis demonstrated positive association vash expression rrm expression human pancreatic cancer tissues bioinformatics analyses revealed induction jun proto oncogene jun vash responsible upregulation rrm expression jun dependent regulation rrm vash confirmed chromatin immunoprecipitation dual luciferase reporter assays demonstrated jun directly binds rrm promoter activate transcription conclusions data suggest vash reduces chemosensitivity gemcitabine pancreatic cancer cells via jun dependent transactivation rrm
adolescent parent psychiatric symptoms well established risk factors adolescent substance use ways symptoms interact well understood study examined interactive effects parent adolescent psychiatric symptoms adolescent frequency alcohol marijuana use effects parental seventy adolescents presenting community mental health center cmhc participated parent adolescent psychiatric symptoms measured brief symptom inventory bsi child behavior checklist cbcl respectively hierarchical regressions revealed different patterns adolescent alcohol marijuana use alcohol bsi parent phobic anxiety subscale predicted increased adolescent use parent interpersonal sensitivity subscale predicted decreased use effects parental symptoms strongest among adolescents higher levels externalizing problems cbcl marijuana bsi parent psychoticism subscale predicted increased adolescent use whereas paranoid ideation predicted decreased use results suggest adolescent treatment assessment attend adolescent parent psychiatric symptoms
present study investigates relative extent judgments people behavior influenced truth measured averaged observer judgments systematic bias perceivers preexisting views target persons using data online questionnaires laboratory sessions demonstrate self peer judgments people actual behavior specific situations somewhat accurate also affected perceivers thought targets observing behavior latter effect comprises general evaluative component generally positive negative views targets content specific component views targets terms specific characteristics example restrained also found friends targets tend judge targets behaviors positively unacquainted observers relevance findings person perception everyday life research contexts discussed
researchers field child neurology increasingly looking supplement clinical trials motor rehabilitation neuroimaging order better understand relationship behavioural training brain changes clinical improvements randomised controlled trials typically accompanied sample size calculations detect clinical improvements despite large cost neuroimaging equivalent calculations concurrently acquired imaging neuroimaging measures changes response intervention aid regard power analysis conducted two measures brain changes may indexed trial rehabilitative therapy cerebral palsy cortical thickness impaired primary sensorimotor cortex fractional anisotropy impaired delineated corticospinal tract power measuring fractional anisotropy assessed region interest seeded fmri seeded diffusion tractography taking account practical limitations well data loss due behavioural image processing issues estimated required participant numbers cortical thickness region interest based tractography fmri seeded tractography respectively numbers adjusted study attrition although participant numbers may reach many trials several options available improve statistical power including careful preparation participants scanning using mock simulators careful consideration image processing options enrolment homogeneous cohort possible work suggests smaller moderate sized studies give genuine consideration harmonising scanning protocols groups allow pooling data isdn published elsevier ltd rights reserved
increasing prevalence food allergies intake packing foods past two decades urge need rapid accurate sensitive assays detect potential allergens food order control allergen content commercial analytical tools allergen detection rely immunoassays elisa far disadvantages elisa time consuming expensive biosensors appear suitable alternative detection allergens rapid highly sensitive selective less expensive environmentally friendly easy handle study developed microfluidic system integrated quantum dots qdots aptamer functionalized graphene oxide nano biosensor simple rapid sensitive food allergen detection biosensor utilized qdots aptamer complexes probes undergo conformational change upon interaction food allergens resulting fluorescence changes due fluorescence quenching recovering properties adsorption desorption aptamer conjugated qdots one step turn homogenous assay ready use microfluidic chip took similar min achieve quantitative detection ara one major allergens appearing peanuts results suggested system remarkable sensitivity selectivity integration microfluidics platform homemade miniaturized optical analyzer provides promising way rapid cost effective accurate site determination food allergens biosensor also extended detection food allergens selection corresponding aptamers elsevier rights reserved
purpose perceptions drawn construction management research cmr community regarding research impact relationship theory generation examined investigative emphasis enablers challenges within academic context paper aims discuss issues design methodology approach qualitative narrative data accrued open ended questions within structured questionnaire survey analysed using frequency quantitative content analysis graphical methods model interface presented discussed findings principal enablers facilitation industry engagement time principal constraints include internal factors academic university external factors collaboration funding respective enablers resources competence time funding corresponding challenges include external factors market forces compliance considered minor challenge research limitations implications study adds empirical evidence ongoing debate within generally regard cmr discipline specifically originality value research relatively sparse findings regard cmr entirely novel
basolateral nucleus amygdala bla critical pathophysiology anxiety driven alcohol drinking relapse endogenous cannabinoid type cannabinoid receptor ecb system curbs bla driven anxiety stress responses via retrograde negative feedback system inhibits neurotransmitter release bla activation reduces gaba release drives anxiogenesis additionally decreased amygdala observed abstinent alcoholic patients ethanol withdrawn rats investigated potential disruption ecb signaling gabaergic transmission bla pyramidal neurons rats exposed weeks intermittent ethanol naive rat bla agonist win win decreased gaba release effect prevented antagonist alone increased gaba release via mechanism requiring postsynaptic calcium dependent activity retrograde tonic ecb signaling diminished chronic ethanol exposed rats suggesting functional impairment ecb system contrast acute ethanol increased gabaergic transmission similarly naive chronic ethanol exposed rats via presynaptic postsynaptic mechanisms notably activation impaired ethanol facilitation gabaergic transmission across groups induced ethanol induced facilitation gaba release additive suggesting independent presynaptic sites action collectively present findings highlight critical influence bla gabaergic transmission dysregulated chronic ethanol exposure thus may contribute alcohol dependent state
vertex disjoint non touching loops processed form combinations disjoint loops mason graph similarly coates graph based method needs spanning disjoint loop sets required obtain transfer function solve equations system represented mason coates signal flow graph boolean formula presented note obtain boolean function formed comprising product sums pairs touching loops connected component simplified using rules boolean algebra resulting terms complemented derive combinations non touching loops mason graph using additional boolean rule formula gives spanning disjoint loop sets coates graph graph need connected
two pole induction machines shaft leads fictitious increase inner yoke rotor effect influenced axial cooling vents rotor pre existing analytical calculation methods estimate magnetic voltage drop rotor one path magnetic flux done simplified boundary conditions leads inaccurate results paper semi analytical method introduced therefore branch current method used solution nonlinear equation system disclosed results analytical calculations validated finite element analysis involvement semi analytical calculation magnetic circuit illustrated refinement steps described applications semi analytical calculation method introduced machine design considerations
objective bronchoalveolar lavage bal diagnostic tool often used management interstitial lung diseases ild however diagnostic value discrimination entities comprising heterogenous group ild still controversial issue objective study assess diagnostic value bal management ild comparing cytological findings bal fluid among different diseases group methods retrospective observational study patients january december bal fluid cytology performed analyse distribution leucocytes population subsets patients ild results mean age years women analysis following main groups diseases performed sarcodosis idiopathic pulmonary fibrosis ipf idiopathic interstitial pneumonia non specific interstitial pneumonia cryptogenic organising pneumonia respiratory bronchiolitis interstitial lung disease connective tissue disease overall patients sarcodosis idiopathic pulmonary fibrosis ipf idiopathic interstitial pneumonia iip connective tissue disease ctd mixed alveolitis common groups sarcodosis higher proportion lymphocytes ipf higher neutrophils count however significant statistical difference bal cellular count among diseases also prevalence studied diseases change variation bal cellular count conclusion alone bal cytological analysis limited value provide substantial information could lead discriminate diseases form ild thus must always associated diagnostic methods
natural language processing nlp field computer science artificial intelligence computational linguistics concerned interactions computers human natural languages idea using natural language computer programming make easier people talk computers native tongue spare pain learning computer friendly language like assembly java lisp etc among natural languages sanskrit style identified best language minimum deviation panini creator sanskrit formulated rules research paper explores varied distinctive features like nlp semantic net vibhakti dual case inflection based syntax etc sanskrit effectively triumphs limitations fulfills prerequisites natural language processor
background virtual reality based methods stroke rehabilitation mainly focused motor rehabilitation increasing interest integrating motor cognitive training increase similarity real world settings unfortunately research needed definition type content used design tools one possibility use emotional stimuli known enhance attentional processes according socioemotional selectivity theory people age emotional salience arises positive neutral negative stimuli methods study developed cognitive motor task involving attention short term memory investigated impact using emotional images varying valence task consisted finding target image shown two seconds among fourteen neutral distractors selecting arm movements performing task recall task took place patients identify target images among valence matched number distractors ten stroke patients participated within subjects experiment three conditions based valence images positive negative neutral eye movements recorded task performance eye tracking system results results show decreased attention negative stimuli task performance compared neutral stimuli recall task shows significantly wrongly identified images false memories negative stimuli neutral regression correlation analyses montreal cognitive assessment geriatric depression scale revealed differential effects cognitive function depressive symptomatology encoding recall positive negative neutral images eye movement data shows reduced search patterns wrongly selected stimuli containing emotional content conclusions results study suggest feasible use emotional content based cognitive motor task attention memory training stroke stroke survivors showed less attention towards negative information exhibiting reduced visual search patterns false memories also shown use emotional stimuli task provide additional information regarding patient mood cognitive status
communion agency fundamental dimensions social perception judgment previous research revealed primacy communion social information processing present research investigates whether similar asymmetry density communion agency test whether communal content densely clustered memory agentic content similar communal content agentic content similar agentic content three multidimensional scaling studies address question suggest interaction valence negative communal content densely clustered negative agentic content find differences density positive communal positive agentic content addition enhancing understanding fundamental dimensions structural representation research might open new perspective old questions regarding person perception implicit personality theories
recently published article clemente padilla racero made incorrect statements regarding richard gardner mental condition identified parental alienation syndrome clemente padilla racero conducted research children concluded gardner ideas parental alienation syndrome particular ease parental manipulation children empirically verified reviewed data research arrived opposite conclusion child subjects age manipulated adult suggestion describe non event conclude data clemente padilla racero consistent gardner theory parent influence child make false statements parent develop false beliefs ultimately false memories non events article features misinformation methodological flaws withdrawn publication elsevier ltd rights reserved
thermochemical splitting via ceria based redox cycle performed solar driven thermogravimetric analyzer overall reaction rates including heat mass transport determined concentrated irradiation mimicking realistic operation solar reactors reticulated porous ceramic rpc structures fibers made undoped doped ceo endothermally reduced radiative fluxes suns temperature range subsequently oxidized rapid uniform heating observed ppi ceria rpc sized porosity due low optical thickness volumetric radiative absorption ceria fibers sized porosity performed poorly due opacity incident irradiation ppi rpc exhibited higher fuel yield higher sample density doped ceria showed increasing reduction extents dopant concentration decreasing specific yield due unfavorable oxidation thermodynamics slower kinetics authors aiche journal published wiley periodicals inc
paper explores drivers business organizations decisions locate sustainable office buildings study uses means end chain mec analysis investigate tenant decision making processes commercial property market fundamental research question identify motivations market participants choose locate green buildings whether aim economics benefits intend promote environmentally responsible first part discusses existing literature referring benefits sustainable buildings perceived market participants next development sustainable office market poland presented finally research data method discussed along findings research study revealed limited environmental awareness real estate market participants poland cost effectiveness selected space corporate image values link choices sustainability office building
paper new circuit topology realizing second order current mode quadrature oscillator proposed three additional circuits derived thus resulting four distinct circuits circuit employs three differential voltage current conveyors grounded passive components ideal implementation circuits possess high output impedance circuits exhibit non interactive frequency control low thd effects non idealities also analyzed pspice simulations using cmos parameters confirm validity practical utility proposed circuits copyright john wiley sons ltd
optical dielectric properties copper oxide cuo made fascinating material used solar energy harvesting gas sensing optoelectronics catalytical applications focusing cost effectiveness sol gel method employed nanostructured cuo production effect changing temperature observed formation mechanism cuo properties temperature range degrees degrees used annealing samples produce defect free cuo nanomaterial prepared material investigated using phase characterization ray diffraction xrd technique scanning electron microscopy sem visible absorption spectroscopy lcr meter structural change prepared cuo observed cluster formation nano fibrils increase annealing temperature crystallites cuo attained using debye scherer formula large band gap achieved increasing annealing temperature upto degrees better solar energy harvest wide band gapped cuo structures proved functional practical materials fabricated cuo nanostructures found suitable used devices stabilizing circuit designs sensitive appliances well micro electromechanical systems mems elsevier rights reserved
african continent continues explore avenues increasing share global fdi inflows midst little said fdi among others contribute environmental degradation continent literature sparse comes eco unfriendly fdi flows could albeit economic growth prowess study employ use year panel data across africa investigate impact fdi inflows eco system order situate africa fdi flows within sustainability development agenda popularized first time investigate governance institutions may regulate impact fdi environmental sustainability conscious fact factors could also impact negatively africa eco system control empirical model empirical results compositely reveal increase fdi inflows significantly increases environmental degradation hence causing negative impact sustainability environment year dummies indicate environmental degradation post era greater degradation used reference point study affirmed fdi positive impact environmental sustainability need strong governance quality institutions place check conduct businesses financed fdi flows study provides empirical evidence anchor governance institutional policy prescriptions towards reducing negative impact fdi flows environmental sustainability within sustainable development preposition elsevier rights reserved
conversation health messages campaigns common message related conversations increasingly recognized consequential factor shaping message effects evidence base limited however conditions conversation may help hinder health communication efforts study college students first watched short sleep video randomly assigned either talk partner online chat conversation proceed directly short survey unknown participants chat partner confederate coached say positive things sleep message positive chat condition negative things negative chat condition unrelated things natural chat condition respondents completed short survey beliefs sleep reactions message intentions get adequate sleep respondents greater intentions engage healthy sleep engaged positive conversation following message exposure engaged negative conversation message positive emotion experienced response message positive chat perceptions significant predictors intentions achieve healthy sleep health message designers may benefit understanding messages exchanged peer peer conversation better predict explain effects
protocol ceremonial present stages history mankind acting instruments nonverbal communication convey messages hierarchy social power recipients since ancient times find references ceremonial rites relate social life events especially symbolic honorary memorial triumphal entries rulers cities coronation inauguration ceremonies weddings funerals members royal families military parades
paper generalized unified method used construct multi rational wave solutions dimensional kadomtsev petviashvili equation variable coefficients extension previous work given author osman abdel gawad epj plus dimensional kadomtsev petviashvili equation variable coefficients used characterize many nonlinear phenomena fluid dynamics plasma physics nonlinear science inhomogeneities media non uniformities boundaries taken consideration give physical insight obtained solutions present graphically representative structures setting arbitrary functions solutions specific functions moreover influences variable coefficient functions interaction properties solitary waves discussed physical interests possible applications
potential injured area athletes image analysis may produce frontier technology method determining attitude sports injuries potential injury prone parts wrist waist knees hidden location image capture almost guarantee continuity image acquisition resulting discontinuous movement image features hard form reasonable judgment three dimensional positioning method motion magnitude proposed basis jointing three dimensional dynamic model target readily obtaining information radial distance azimuth doppler athlete according visual data establishing maximum likelihood estimation moving amplitude three dimensional target positioning achieve judgment target simulation results show potential sports injuries pose based three dimensional image analysis effectively improve judging accuracy injury attitude internal division media space distribution injury reducing injury probability long course providing better protection potential movement
low dimensional model describes saturated unsaturated flow processes single equation presented subsurface flow processes groundwater vadose zone capillary fringe accounted computation aggregated hydrodynamic parameters result integration governing flow equations bedrock land surface three dimensional subsurface flow dynamics thus described two dimensional equation allowing drastic reduction model unknowns simplification model parameterizations approach compared full resolution richards equation different synthetic test cases model reduction stems vertical integration flow equations test cases use different configurations heterogeneity vertical cross sections soil aquifer system low dimensional flow model shows strong consistency results complete resolution richards equation water table fluxes proposed approach therefore well suited accurate reproduction complex subsurface flow processes
objective intestinal permeability impairment implicated many gastrointestinal diseases chronic diarrhea defined presence diarrhea weeks adults weeks children requires different diagnostic therapeutic work acute diarrhea gelatin tannate reducing clinical activity acute colitis proinflammatory effects lipopolysaccharide lps emerging mucosal barrier protector materials methods new therapeutic strategies focusing physiological function intestinal barrier may offer innovative approach clinical improvement highly debilitating chronic diseases review available data role gelatin tannate tyndallized probiotics treatment diarrhea results gelatin tannate tyndallized probiotics used establish physiological functions gut barrier well preventing dysbiosis evidence due particular properties gelatin tannate tyndallized probiotics highly effective treatment acute gastroenteritis may especially indicated management moderate prolonged diarrhea conclusions gelatin tannate tyndallized probiotics may effective management chronic diarrhea clinical trials necessary explore effects clinical practice
present top algorithm retrieving tuples according order provided ranking function belongs subclass non monotonic functions ranking functions defined values maximum score achieved test proposed algorithm various real artificial data varying variable ranges different non monotonic ranking functions
one major concerns construction industry sustainability building projects various trade offs functionality design often lead issue whether sustainably designed buildings would meet stakeholder requirements paper provides novel integrated structure assessing green buildings realistically based stakeholders fuzzy preferences particular paper uses analytic network approach anp evaluate correlation matrices quality function deployment qfd framework case study green building index assessment malaysia illustrates proposed integrated method sensitivity analysis validated customer stakeholder agreement towards design green building cluster analysis also used group design specifications prior analysis
domains parallel distributed computing converging continuously degree state art server computer systems incorporate characteristics domains comprise hierarchy enclosures enclosure houses multiple processor sockets socket contains multiple memory controllers global address space cache coherency facilitated using multiple layers fast interconnection technologies even across enclosures growing popularity systems creates urge efficient mappings cardinal algorithms onto hierarchical architectures however growing complexity systems inconsistencies implementation strategies different hardware vendors make increasingly harder find efficient mapping strategies universally valid paper present scalable optimization mapping strategies case study popular scale invariant feature transform sift computer vision algorithm approaches evaluated using state art hierarchical non uniform memory access numa system physical cores terabytes memory apportioned across numa nodes sockets sift particularly interesting since algorithm utilizes variety common data access patterns thus allowing discuss scaling properties optimization strategies distributed parallel computing domains applicability emerging server systems
background analyses subcortical gray structure volumes non demented idiopathic parkinson disease often always show volume loss putamen caudate nucleus nucleus accumbens hippocampus building evidence structure morphometry might sensitive disease related processes volume objective assess morphometric differences subcortical structures putamen caudate nucleus thalamus globus pallidus nucleus accumbens amygdala well hippocampus non demented individuals relative age education matched non peers methods prospective recruitment idiopathic dementia non peers part federally funded investigation weighted isovoxel metrics acquired via siemens verio individuals left side onset right side onset non first fmrib software library applications provided volumetric vertex analyses group differences structure size morphometry results group volume differences observed putamen hippocampi non hippocampal volume significantly associating disease duration group shape differences observed bilateral putamen caudate nucleus hippocampus greater striatal atrophy contralateral side motor symptom onset hippocampal shape differences disappeared removing effects volume conclusion putamen primary structure show volume shape differences indicating putamen predominant site basal ganglia atrophy early mid stage side symptom onset associates contralateral striatal atrophy left onset might experience extensive striatal atrophy right onset hippocampus morphometric results suggest possible primary atrophy dentate gyrus
offenders high psychopathic traits antisocial personality disorder aspd hypothesised experience less guilt less responsibility actions offenders without problems hypotheses tested partly substantiated study investigates blame attributions guilt feeling using gudjonsson blame attribution inventory revised gbai young male violent offenders gbai scores compared aspd psychopathy according psychopathy checklist revised results showed individuals aspd higher degrees psychopathy tended report significantly less guilt higher degree mental control subjects another finding weak relationship aspd high scores psychopathic traits external attribution suggest results might explained admitting poor mental control may extra difficult individuals belonging either groups external attribution items separate causal moral responsibility
background epithelial mesenchymal transition currently recognized important mechanism increased number myofibroblasts cancer fibrotic diseases already reported epithelial mesenchymal transition involved airway remodeling induced eosinophils procaterol selective full beta adrenergic agonist used rescue asthmatic attack inhaler form orally controller study evaluated whether procaterol suppress epithelial mesenchymal transition airway epithelial cells induced eosinophils methods epithelial mesenchymal transition assessed using culture system human bronchial epithelial cells primary human eosinophils eosinophilic leukemia cell line results procaterol significantly inhibited culture associated morphological changes bronchial epithelial cells decreased expression vimentin increased expression cadherin compared control butoxamine specific beta adrenergic antagonist significantly blocked changes induced procaterol addition procaterol inhibited expression adhesion molecules induced interaction eosinophils bronchial epithelial cells suggesting involvement adhesion molecules process epithelial mesenchymal transition forskolin cyclic adenosine monophosphate promoting agent exhibits similar inhibitory activity procaterol conclusions overall observations support beneficial effect procaterol airway remodeling frequently associated chronic obstructive pulmonary diseases
background although past decade management invasive fungal infection improved considerable controversy persists regarding antifungal prophylaxis solid organ transplant recipients aims identify key clinical knowledge make consensus high level recommendations required antifungal prophylaxis solid organ transplant recipients methods spanish prospective questionnaire measures consensus delphi technique conducted anonymously mail national multidisciplinary experts specialists invasive fungal infections six national scientific societies including intensivists anesthetists micro biologists pharmacologists specialists infectious diseases responded questions prepared coordination group exhaustive review literature last years level agreement achieved among experts categories equal greater order make clinical recommendation second term extracting recommendations selected topics face face meeting held specialists asked validate pre selected recommendations derived algorithm measurements primary outcomes echinocandin antifungal prophylaxis considered liver transplant major risk factors retransplantation renal failure requiring dialysis transplantation pretransplant liver failure early reoperation meld heart transplant hemodialysis surgical exploration transplantation environmental colonization aspergillus cytomegalovirus cmv infection pancreas intestinal transplant case acute graft rejection hemodialysis initial graft dysfunction post perfusion pancreatitis anastomotic problems need laparotomy transplantation antifungal fluconazole prophylaxis considered liver transplant without major risk factors meld split living donor choledochojejunostomy increased transfusion requirements renal failure without replacement therapy early reoperation multifocal colonization infection candida intestinal pancreas transplant risk factors echinocandin treatment liposomal amphotericin antifungal prophylaxis considered lung transplant inhalant form liver transplant major risk factors antifungal prophylaxis voriconazole considered lung transplant heart transplant hemodialysis surgical exploration transplantation environmental colonization aspergillus cmv infection conclusions management antifungal prophylaxis solid organ transplant recipients requires application knowledge skills detailed recommendations algorithm developed therein recommendations based delphi methodology may help identify potential patients standardize management improve overall prognosis asociacion espafiola micologia published elsevier espana rights reserved
improving mainstream perceptions diversity hong kong fundamental enhancing equality human rights society future importance mainstream members society learning recognize diversity less prejudice undergirds many aims recent educational reform liberal studies paper evaluates capacity liberal studies educate multicultural understanding cultural difference primary data source liberal studies textbooks employs qualitative content analysis consider diversity ethnic cultural religious differences represented texts analysis complemented examination related resources teachers may use classroom encouraged use hong kong curriculum development council mainstream news articles resources government provided web based resource platform liberal studies voices views practicing teachers pre service teacher education students related multicultural liberal studies resources also included provide balanced picture based analysis multicultural education provided major resources within liberal studies curriculum appears inadequate diversity reflected upon resources analyzed often problematic stereotypical interventions needed liberal studies enable multicultural appreciation understanding among students hong kong future
traditionally testosterone estrogen considered male female sex hormones respectively however estradiol predominant form estrogen also plays critical role male sexual function estradiol men essential modulating libido erectile function spermatogenesis estrogen receptors well aromatase enzyme converts testosterone estrogen abundant brain penis testis organs important sexual function brain estradiol synthesis increased areas related sexual arousal addition penis estrogen receptors found throughout corpus cavernosum high concentration around neurovascular bundles low testosterone elevated estrogen increase incidence erectile dysfunction independently one another testes spermatogenesis modulated every level estrogen starting hypothalamus pituitary gonadal axis followed leydig sertoli germ cells finishing ductal epithelium epididymis mature sperm regulation testicular cells estradiol shows inhibitory stimulatory influence indicating intricate symphony dose dependent temporally sensitive modulation goal review elucidate overall contribution estradiol male sexual function looking hormone effects erectile function spermatogenesis libido
high performance magnetic resonance imaging systems gradient driver required supply gradient coil large current high voltage achieve strong gradient field fast slew rate addition extremely high fidelity reproducing current command central system critical imaging quality paper presents solutions different elements driver high bandwidth power inverter ripple cancelation filter multioutput power supply digital control high power inverter requires stacked bridges structure achieve high output ripple frequency existing commercial power semiconductor modules high voltage high frequency large power modules obtained easier lower loss using new silicon carbide devices control needs digital implementation fast processor digital control provides compensation feedforward improve response capability improvement obtained reducing switching frequency large currents low frequency variation needed control handle well filter designed eliminate one ripple frequency finally many solutions used multiple isolated outputs digital control compensation permits use much simpler unregulated keeps performance mva platform built fully tested experimental results proved validity proposed structure modulation technique
two strains nitrogen fixing cyanobacterium anabaena native indian paddy fields displayed differential sensitivity exposure uranyl carbonate neutral anabaena strain pcc anabaena strain displayed reduction survival dose following exposure uranyl carbonate respectively uranium responsive proteome alterations visualized gel electrophoresis followed protein identification maldi tof mass spectrometry two strains displayed significant differences levels proteins associated photosynthesis carbon metabolism oxidative stress alleviation commensurate uranium tolerance higher uranium tolerance anabaena strain could attributed sustained photosynthesis carbon metabolism superior oxidative stress defense compared uranium sensitive anabaena strain pcc significance uranium responsive proteome modulations two nitrogen fixing strains anabaena native indian paddy fields revealed rapid adaptation better oxidative stress management maintenance metabolic energy homeostasis underlies superior uranium tolerance anabaena strain compared anabaena strain pcc elsevier rights reserved
background systematic screening recommended major depressive episode mde neurological disorders depression inventory epilepsy nddi items generalized anxiety disorder gad gad items patients epilepsy pwe shorter versions nddi gad could facilitate increased screening busy clinicians accessible patients mild cognitive language impairments methods effectiveness ultra short versions nddi items gad gad items gad single item comparison original versions statistically tested using roc analysis results roc analysis nddie showed auc sensitivity specificity without significant difference nddi roc analysis gad showed auc sensitivity specificity without significant difference gad gad showed poorer psychometric properties limitations limitation use data previously reported subjects single language version nddie lacks detection dysphoric symptoms comparison nddie gad exhibited lower sensitivity gad conclusions study highlights potential utility nddie gad ultra short screening tools mde gad respectively pwe studies larger population including multi lingual versions could valuable next step however brevity simplicity tool could advantage pwe present cognitive difficulties especially attentional language deficits
medical image visualization also known medical image reconstruction technique theory method technique use computer graphics image processing computer vision human computer interaction techniques reconstruct stereoscopic image received medical images mri etc display screen interact currently medical image visualization technology hot medical image processing great significance theory research clinical applications paper mainly introduces key techniques medical image visualization designs system medical image visualization based vtk system integrates marching cubes ray casting visualization algorithm implements function dicom format medical images file read reconstruction display system applied medical diagnosis medical education medical research etc
incarcerated fathers often experience early life risk factors cumulate time compounded negative repercussions imprisonment dynamics may contribute intergenerational transmission risk help explain persistent link paternal incarceration poor child outcomes contact incarcerated fathers children benefit limited research factors affect father child contact using data survey inmates state correctional facilities sample fathers least one minor child authors found incarcerated fathers experienced childhood risk factors less frequent contact children variety inmate characteristics also significant predictors father child contact parenting interventions could address incarcerated fathers childhood risk experiences likely undermine development maintenance family relationships help develop prosocial skills
principle structural configuration active controlled microfluidic valve annular boundary driven circular piezoelectric unimorph actuator presented article active controlled flowrate modeled using classical laminated plate theory extended bernoulli equation fluid mechanics according established mathematical model simulate analyze influence voltage applied circular piezoelectric unimorph actuator structural parameters flow characteristics prototypes active controlled microfluidic valves annular boundaries three different combinations inner outer radii fabricated tested experimental results show active controlled microfluidic valves annular boundaries possess switching capability continuous control capability fluid simple structure easy fabrication processing maximum flowrate active controlled microfluidic valve annular boundary inner outer radii respectively differential pressure inlet outlet active controlled microfluidic valve voltage applied circular piezoelectric unimorph actuator established flowrate model accurately predict controlled flowrate active controlled microfluidic valves maximum relative error
buildings commercial non commercial purpose consume large amount electricity therefore design green smart city biggest challenge designer convert buildings energy consumer energy producer recent study reveals designer prefer solar energy smart city development housed limited space characterized pollution free environment friendly sustainable well noise free source electricity among photovoltaic technologies rooftop building integrated photovoltaic bipv technology commonly adopted technologies green building paper presents comparative study cost benefit analysis roof top solar bipv technology making green campus university engineering management kolkata phase result study help designer select proper photovoltaic technology develop green city cost effective way
public health research treats intimate partnerships sites risk management including management hiv hepatitis transmission risk infused biomedical approach tends undermine appreciation emotional socially situated meanings care intimate partnerships article explore qualitative interview accounts care enacted partnerships people inject drugs drawing study couples individuals living two locations australia thematic analysis highlights best friend relationships everything together dependency normalcy core narratives care argue accounts position care undertaken couples shaped day day practices drug use social situation partnership enacting care form social protection including protection stigma environmental hostilities intimacy everything together offers insulation stigma yet also reproduces isolating effects care produced drug using partnerships presented double edged note interview accounts used deflect charge relationships represent harmful dependency taken together interview accounts negotiate counter care relation normalcy presenting intimate partnership people use drugs legitimate embodiment care published elsevier ltd
major scientific flaws reporting publication biases well documented even though acknowledgment importance appears lacking various psychological medical fields subtle less obvious biases including selective reviews literature empirically unsupported conclusions recommendations received even less attention using literature association transition menopause hormones onset depression guiding example outline scientific fallacies undermine validity neuroendocrinological research shown contrast prominent claims first prospective studies support notion menopausal transition relates increased risk depression second associations hormone levels depression largely inconsistent irreproducible third evidence efficacy hormone therapy treatment depression weak best inconclusive conclude direct uniform association female sex hormones depression clearly supported literature attention paid manifold scientific biases undermine validity findings psychological medical research specific focus behavioral neurosciences
children adolescents united states spend many hours school students chronic health conditions chcs may face lower academic achievement increased disability fewer job opportunities limited community interactions enter adulthood school health services provide safe effective management chcs often students limited access health care systematic review assess role school health services addressing chcs among students grades completed using primary peer reviewed literature published selected conditions asthma food allergies diabetes seizure disorders poor oral health thirty nine articles met inclusion criteria results synthesized however asthma direct access school nursing health services well disease specific education improved health academic outcomes among students chcs future research needs include standardized definitions data collection methods students chcs
wireless sensor networks wsns growing subset emerging internet things iot wsns reduce cost deployment wired alternatives consequently use increasing home automation critical infrastructure smart metering security solutions published works evaluate security proprietary wsn protocols due lack low cost effective research tools one protocol itu based wave maintains wide acceptance within iot market concurrently use software defined radios sdrs experiencing significant growth due lowcost open source platforms using sdrs network security professionals able evaluate wsns identify avenues attack historically required large investments equipment specialized skill sets recent work introduces scapy radio generic sdr based wireless monitor injection tool designed simplify development penetration testing capabilities wireless networks works demonstrate methods fingerprinting transceivers ieee ieee standards analyzing packet reception rates preamble lengths manipulated work significantly expands scapy radio providing broad support wave protocol using low cost hackrf sdr investigate cooperative non cooperative fingerprinting techniques specifically work demonstrates transceiver type fingerprinting experimental analysis packet reception respect preamble length across eight devices five manufactures utilizing two widely used wave transceivers furthermore work presents wave set wave network reconnaissance tools capable network discovery enumeration device fingerprinting gathering device status information herein work successfully demonstrates methods conducting network reconnaissance wave home area network transceiver type fingerprinting preamble manipulation greater accuracy
enhanced removal abnormal protein aggregates injured organelles autophagy related neuroprotection parkinson disease study explored whether induction autophagy associated neuroprotection rosemary carnosic acid hydroxydopamine ohda induced neurotoxicity syy cells results indicated cells treated increased protein levels parkin autophagy related markers including phosphatidylinositol kinase beclin autophagy related gene microtubule associated protein light chain well enhanced formation autophagic vacuoles treatment cells ohda decreased levels parkin autophagy markers pretreatment reversed effects however wortmannin autophagosome formation blocker pretreatment attenuated effect pretreatment induction cleaved caspase cleaved poly adp ribose polymerase nuclear condensation ohda alleviated wortmannin bafilomycin autophagosome lysosome fusion blocker inhibited anti apoptosis effects additionally performed immunoprecipitation anti parkin antibody found interaction parkin beclin protein reduced ohda effect reversed cells pretreated moreover transfection parkin sirna cells inhibited ability alleviate ohda decreased autophagy related markers nuclear condensation conclusion protects ohda induced apoptosis inducing autophagy interaction parkin beclin results provide future strategy use prevention parkinson disease
modern video games represent highly advanced virtual reality simulations often contain virtual violence significant amount young males playing video games quotidian activity making almost natural behavior recordings brain activation functional magnetic resonance imaging fmri gameplay may reflect neuronal correlates real life behavior recorded experienced gamers years average hrs week playing playing violent first person shooter game violent computer game played self perspective means distortion dephasing reduced fmri single shot triple echo echo planar imaging epi content analysis video sound time resolution achieved relevant behavioral variables variables explained significant signal variance across large distributed networks occurrence violent scenes revealed significant neuronal correlates event related design activation dorsal deactivation rostral anterior cingulate amygdala characterized mid frontal pattern related virtual violence statistics effect sizes considered large areas optimized imaging strategies allowed single subject single trial analysis good image quality basal brain structures propose virtual environments used study neuronal processes involved semi naturalistic behavior determined content analysis importantly activation pattern reflects brain environment interactions rather stimulus responses observed classical experimental designs relate findings general discussion social effects playing first person shooter games
present experiment conducted investigate whether negative emotionally charged arousing content remembered scripted material would affect propensity towards memory distortions investigated whether elaboration studied material free recall would affect magnitude memory errors study participants saw eight scripts scripts included effect action cause presented effects either negatively emotional neutral participants assigned either yes recognition test group recognition recall yes recognition test group elaboration recognition results showed participants recognition group produced fewer memory errors emotional condition conversely elaboration recognition participants lower accuracy produced emotional memory errors group suggesting mediating role semantic elaboration generation false memories role emotions semantic elaboration generation false memories discussed
background although adolescents successfully manage transition childhood adulthood speed magnitude changes may exceed coping abilities significant number young people vocational students additional responsibilities arise vocational school transition need balance academic job related requirements expanding body literature suggests adolescence vulnerable period development psychiatric diseases need develop adequate coping repertoire receiving increasing attention globally growing awareness long term consequences stress led governments instill school based resilience promotion programs instance new physical education curriculum vocational vocational education training vet students switzerland addresses stress management stress related diseases workplace become commonplace among young professionals purpose aim develop implement evaluate based coping training ephect vet students therefore adapted components extant field tested coping training programs tailored unique needs vet students facilitate standardization program teacher received teaching manual moreover drawing upon experiential learning theory introduced contents coping training class practical movement based exercises students also received workbook use home participants research design cluster randomized controlled trial eight classes swiss vocational school participated age females two trained teachers implemented program students intervention group three months students four classes maintained regular comprise control group evaluate coping training participants completed several self report psychological questionnaires assessing stress coping sleep baseline follow students completed questions regard intervention fidelity follow data analysis evaluate possible effects coping training stress coping sleep repeated measures analysis variance design executed time pre post group within subject factors findings time students significantly increased adaptive coping compared students stress sleep remained relatively stable regularly completing one homework reinforced effect significantly associated students reflection compliance conclusion complete accurate implementation based coping training make positive contribution development adaptive coping skills among adolescents attending vocational schools based program allows students experience responses stress directly offers opportunities experiment different coping strategies adaptive coping skills vital successful stress management prevention stress related disorders across work domain everyday life
introduction therapeutic use animals debated decades use explored variety settings populations however uniformity naming interventions evidence based knowledge essential implement effective strategies hospital review focused use animal programs hospitalized patients considered potential risks methods following databases searched pubmed scopus psychinfo ebsco animals proquest web science cinahl medline prisma guidelines adhered results articles identified articles suitable inclusion review data heterogeneous terms age patient health issue animals used length interactions made comparison problematic studies children psychiatric elderly patients common animal intervention programs suggested various benefits reducing stress pain anxiety outcomes considered changes vital signs nutritional intake studies used dogs animals effectively employed major risks outlined allergies infections animal related accidents zoonosis possible risk well common infections methicillinresistant staphylococcus aureus implementation simple hygiene protocols effective minimizing risk literature suggested benefits outweighed far risks conclusion human relationship animals useful relatively safe inpatients various problems moreover implementation security precautions careful selection patients minimize risks particularly infection related many aspects remain unclear studies required elsevier gmbh rights reserved
objective unintended pregnancy important public health problem world due negative effects mother child health common causes unintended pregnancies nonuse misuse contraceptive methods aim study determine recognition frequency emergency contraceptive methods among women related factors situation material method descriptive study conducted research education hospital obstetrical outpatient clinics women aged years attend clinics due health problem enrolled study data collected questionnaire generated investigators values considered significant results fifty five point five percent women enrolled study using modern contraceptive methods faced unintended pregnancy least one time sexual life unintended pregnancies resulted deliveries rate unintended pregnancy higher women higher pregnancy count forty eight point nine percent participants thought impossible prevent pregnancy unprotected sexual intercourse rate women aware least one synonymous expressions emergency contraception forty five women known exact meaning emergency contraception emergency contraception usage rate general population women aware emergency contraception conclusion possible decrease unintended pregnancies using emergency contraception properly however knowledge women emergency contraception inadequate therefore education programmes conducted
paper focuses variability vibration electromagnetic origin electric motor multiphysics modeling introduced magnetic force density computation coupling electromagnetic structural dynamic finite element models modal stability procedure msp monte carlo simulation mcs associated variability calculation natural frequencies frequency response functions frfs finite element systems material random parameters msp formulations developed node solid hexahedron element modeling electric stator mcs msp approach requires single finite element analysis leading fast monte carlo simulation using msp formulation validation mcs msp investigated uncertainty propagation discussed computational costs mcs msp presented non intrusive method provides evaluation frequencies frfs variability industrial size models large number degrees freedom large number random variables low moderate variability level elsevier rights reserved
proper protein localization essential critical cellular processes including vesicle mediated transport protein translocation tail anchored proteins integrated organellar membranes via terminus orienting terminus towards cytosol localization proteins occurs posttranslationally governed terminus contains integral transmembrane domain tmd targeting sequence targeting proteins dependent hydrophobicity tmd well length composition flanking amino acid sequences previously identified unusual homologue elongator protein elp apicomplexan parasite toxoplasma gondii protein targeting outer mitochondrial membrane sought gain insight proteins targeting mechanisms using early branching eukaryote model bioinformatics analysis uncovered predicted proteins toxoplasma selected follow analyses based representative features identified novel proteins traffic specific organelles toxoplasma including parasite endoplasmic reticulum mitochondrion golgi apparatus domain swap experiments elucidated targeting proteins specific organelles strongly influenced tmd sequence including charge flanking terminal sequence
locally commissioned pharmacy public health services developed england last years studies sought pharmacist views commissioning provision public health services general study sought views community pharmacists areas england services provided decisions services support promotion future developments using postal questionnaire two reminders response rate funded public health services provided frequently emergency contraception smoking cessation supervised drug consumption blood pressure monitoring provided considered one services pharmacists perceived valued customers national health services nhs funded motivation providing public health services professional financial particularly working independent pharmacies personally involved deciding services deliver fewer based decisions local public health reports pharmacists positive attitudes towards providing public health services mixed views support services promotion thought services would increase future concerned commissioning national local support needed ensure future commissioning pharmacy public health services
background study aimed identify resilience burnout status nurses working field oncology methods descriptive study conducted oncology nurses data collected using sociodemographic attributes form resilience scale adults maslach burnout inventory percentage ratios mean median values kruskal wallis test mann whitney test correlation analysis multiple stepwise linear regression analysis used evaluate data results maslach burnout inventory total median score emotional exhaustion median score depersonalization median score personal accomplishment median score resilience scale adults total median score median resilience subscale scores structural style perception future family cohesion self perception social competence social resources respectively relationship existed emotional exhaustion perception future depersonalization structured style self perception personal accomplishment structured style perception future self perception multiple stepwise linear regression analysis revealed significant relationship number years field emotional exhaustion depersonalization scores moreover significant relationship structured style variables personal accomplishment scores observed conclusions study demonstrated relationship burnout resilience situations among oncology nurses results used plan individual organizational interventions increase resilience reduce experience burnout developing measures improving communication skills providing education stress management coping strategies using social resources organizing programs provide psychological support
objectives examine effects postacute discharge setting unplanned hospital readmissions following total knee arthroplasty tka older adults design secondary analyses medicare inpatient claims files setting acute hospitals across united states participants medicare fee service beneficiaries years age discharged acute hospital following tka measurements outcome measure unplanned readmissions days independent variable interest postacute discharge setting inpatient rehabilitation facility irf skilled nursing facility snf community covariates included demographic clinical facility level factors top reasons readmission tabulated discharge setting across consecutive day time periods results total patients admitted within days compared community discharge patients discharged irf snf higher odds day readmission respectively irf snf discharge settings also associated higher odds day readmission respectively compared community discharge largest increase readmission rates occurred within first days hospital discharge discharge setting days postoperative post traumatic infections among top causes readmission discharge settings days postoperative traumatic infections remained top reasons readmission settings top days conclusions patients discharged either snf irf comparison discharged community greater likelihood readmission within days reasons readmission relatively consistent across discharge settings time periods findings provide new information relevant delivery postacute care older adults following tka amda society post acute long term care medicine
advances prenatal diagnosis perioperative management postoperative care dramatically increased population survivors neonatal infant heart surgery high survival rate patients adulthood exposed alarming prevalence long term neuropsychological psychiatric morbidities dextro transposition great arteries tga one extensively studied cyanotic congenital heart defect chd regard neurodevelopmental outcomes landmark studies described common neurodevelopmental behavioral phenotype associated tga children tga display impairments key neurocognitive areas including visual spatial fine motor abilities executive functioning processing speed social cognition grow older may face additional challenges worsening deficits higher order cognitive skills problems psychosocial adjustment higher expected rate psychiatric disorders attention deficit hyperactivity disorder depression anxiety aim review summarize available recent data neuropsychological psychiatric outcomes individuals tga arterial switch operation present findings within life span perspective particular emphasis emerging literature adolescent young adult outcomes finally propose avenues future research chd adult neuropsychology field among avenues explore potential mechanisms pediatric neurodevelopmental impairments may lifelong adverse effects well alternative interventions could optimize outcomes
synopsis backgroundthe megatrend population ageing leading growing demand anti ageing treatments especially prevent treat skin ageing facing increasing offer consumers choosing skin care products supported scientific rationale active ingredients clinical proof efficacy objectiveconsidering consumer expectations research led discovery acetyl aspartic acid novel active ingredient improve sagging skin loss skin firmness resultsthis supplement featuring seven manuscripts aiming presenting research investigations consumer insights discovery invitro activity confirmation safety assessment formulation dermal absorption clinical proof efficacy investigated two pilots double bind randomized placebo controlled studies photo aged skin conclusionthis extensive research enabled discover active ingredient potential repair sign skinageing supported clinical proof efficacy active ingredient soon launched commercial innovative skin care range delivering desirable anti wrinkle skin lifting benefits resume contextela tendance mondiale vieillissement population entraine une demande croissante pour des traitements particulier pour prevenir traiter vieillissement cutane face une offre croissante les consommateurs choisissent plus plus produits soins peau soutenus par discours scientifique des ingredients actifs des preuves cliniques efficacite objectifconsiderant les attentes des consommateurs cette recherche conduit decouverte acide aspartique acetyle nouvel ingredient actif pour combattre relachement cutane perte fermete peau resultatsa travers sept manuscrits supplement presente ensemble travaux recherche partir identification des besoins des consommateurs decouverte suivie confirmation son activite invitro evaluation securite formulation confirmation son absorption cutanee finalement preuve clinique efficacite via deux etudes pilotes double aveugle randomisee contre placebo sur peau photo agee conclusioncette recherche approfondie nous permis decouvrir comme ingredient actif avec potentiel reparation des signes vieillissement peau validee par preuve clinique efficacite cet ingredient actif sera lance bientot dans une gamme soins peau innovante
number second generation non sedating antihistamines used clinical practices world however long term safety efficacy proved high level evidence based medicine performed open label multicenter phase iii study evaluate long term safety efficacy bilastine novel non sedating antihistamine patients chronic spontaneous urticaria csu pruritus associated skin diseases trial registration japiccti patients aged years treated bilastine daily weeks safety tolerability assessed basis adverse events bilastine related laboratory tests vital signs efficacy assessed based rash score itch score overall improvement quality life one hundred ninety eight patients enrolled completed week treatment period reported bilastine related patients throughout week treatment period mild moderate severity associated nervous system occurred patients including seven patients headache somnolence reported two patients related bilastine efficacy variables improved treatment bilastine conclusion long term treatment bilastine daily weeks safe well tolerated japanese patients csu pruritus associated skin diseases bilastine improved disease symptoms conditions early treatment efficacy maintained throughout treatment
nonsuicidal self injury nssi associated reduced pain sensitivity existing theories posit altered risk factor nssi cross sectional data suggest normalizes terminating self injury however previously study addressed longitudinal course patients engaging nssi addressed changes clinical symptomatology adolescents nssi matched controls one year despite significant clinical improvements change nssi group decreased controls greater nssi reduction associated increased pain tolerance findings discussed light current theories nssi elsevier ltd rights reserved
hyperphosphorylation tau forming neurofibrillary tangles considered crucial event pathogenesis alzheimer disease mir belongs microrna mirna family markedly decreased however functions mir pathogenesis remain unknown observed expression mir significantly decreased appswe cells transfection mir mimics attenuated cell apoptosis abnormal hyperphosphorylation tau protein without changes total tau protein also increased expression levels caveolin phosphoinositide kinase pik phospho akt akt ser akt phospho glycogen synthase kinase beta gsk beta ser gsk beta appswe cells found mir directly targeted caveolin mir inhibited abnormal hyperphosphorylation tau regulating caveolin pik akt gsk beta pathway study reveals mir may play neuroprotective role may provide new ideas therapeutic targets
according cognitive load theory using worked examples effective efficient instructional strategy initial cognitive skill acquisition novice learners reduces cognitive load frees cognitive resources build task competence contrary productive failure well invention learning desirable difficulties problem solving first frameworks suggest scaffolded problem solving activities generation phase preceding explicit instruction enhance learners performance reported experimental study investigated effectiveness different levels instructional guidance provided students learning phase preceding explicit instruction standard solution procedures enhancing students engagement transfer problem solving skills specifically study compared partially guided unguided attempts generating problem solutions opposed comprehensive guidance form worked example levels experienced cognitive load learner motivation evaluated addition delayed post test performance scores differences three groups transfer post test outcomes even though condition fully guided worked examples prior explicit instruction expectedly reduced cognitive load relative conditions without guidance also differences conditions sub dimensions motivation scale general findings indicate similar overall outcomes delayed transfer performance could achieved different sequences instructional tasks aimed achieving different sets specific goals
study design retrospective cohort objective purpose present study examine incidence risk factors postoperative hematoma requiring reoperation patients undergoing single level lumbar fusion surgery summary background data postoperative hematoma cause devastating neurological consequences spine surgery risk factors hematoma specific spine procedures well established methods cohort patients undergoing single level lumbar fusion surgery constructed american college surgeons national surgical quality improvement program dataset using current procedural terminology codes cases requiring reoperation within days initial surgery postoperative hematoma identified using icd code risk factors postoperative hematoma assessed logistic regression modeling results patients undergoing single level lumbar fusion surgery patients developed postoperative hematoma requiring reoperation hematoma evacuation heightened incidence postoperative hematoma found patients smokers nonsmokers diagnosis bleeding disorder without bleeding disorder multivariate logistic regression analysis indicated adjusted odds ratios postoperative hematoma associated smoking bleeding disorder confidence interval confidence interval respectively conclusion smoking bleeding disorder appear major risk factors postoperative hematoma requiring reoperation single level lumbar fusion surgery intervention programs targeting patients risk factors needed reduce excess risk postoperative hematoma
paper presents virtual try system correctly visualize objects glasses face given user capturing image depth information user low cost rgb camera apply face tracking technique detect specific landmarks facial image landmarks point cloud reconstructed depth information combined optimize facial morphable model fits good possible user head face end deform chosen objects rest shape deformed shape matching specific facial shape user last step projects renders object original image enhanced precision proper scale showing selected object user face validate performance system eight different subjects four male four female show results numerically visually results demonstrate fitting facial model user face rendered virtual objects look realistic
paper presents robust control design integrate hydro generators address increased frequency deviations power systems high wind power penetration robust control design framework hydro governors proposed order particularly tackle disturbances wind power fluctuation first combining state equations hydro thermal wind generators power flow equations network state space model entire power system derived control design hydro generators particular characteristics wind power variations hydraulic system dynamics hydroelectric power plants implemented system model infinity based robust controller synthesized reducing order system model using linear matrix inequality method finally ieee bus test system used verify performance designed robust controller wind penetration levels simulation results compared traditional pid controller research findings indicate proposed robust controller significantly reduces system frequency deviations enables hydro generators responsive wind power variation primary frequency regulation power systems
anterior cingulate cortex acc commonly associated cognitive control decision making specific function highly debated explore recent theory acc learns reward values task contexts holroyd mcclure psychological review holroyd yeung trends cognitive sciences recorded event related brain potentials erps participants played novel gambling task participants first required select among three games one virtual casino subsequently required select among three different games different virtual casino unbeknownst payoffs games higher one casino analysis reward positivity erp component believed reflect reward related signals carried acc midbrain dopamine system revealed acc sensitive differences reward values associated casinos games inside casinos indicating participants learned values contexts rewards delivered results highlight importance acc learning reward values task contexts order guide action selection
centric gaming concept creates environment people play games living room gathered around screen games controlled mobile devices using controllers also personal screens player centric gaming concept hard commercially deploy due lack common programming platform customer premise equipment however recent developments operating systems may allow rebooting centric gaming approach paper presents proposal integrating centric concept modern internet based ecosystem potential business case regards top services means deploying concept practice
lots evaluations work life made uncertain conditions conventional databases effective records users could always information need moreover usage crisp value criteria queries makes impossible records close provide query criteria reasons receiving information database creation queries increase significant results define possible information users gaining importance study solution identification problem communication base stations operating residential areas already installed country aimed usage fuzzy queries classical databases method taken consideration improve method solve stated problem examined enterprise context using fuzzy queries related database interface frame identified rules assumptions reporting evaluation results proved
examined whether two interpersonal processes self disclosure affirmation ideal self mediated relationship cross ethnic friendships psychological well academic outcomes conducted cross sectional survey secondary school children white european south asian british age boys girls recruited multiethnic classrooms results multilevel structural equation modeling revealed mediational effects self disclosure cross ethnic friendships psychological well south asian children affirmation also mediated association cross ethnic friendships psychological well academic outcomes south asian children white european children affirmation mediated association cross ethnic friendships psychological well analyses demonstrated self disclosure resulting cross ethnic friendship quality facilitated affirmation turn promoted sets outcomes findings demonstrate cross ethnic friendships multiethnic settings contribute well generation positive interpersonal processes
radiculopathy known cause occipito cervical pain pathology unclear rarity unique anatomy paper investigated mechanism radiculopathy underwent microscopic cervical foraminotomies mcf three cases radiculopathy treated mcf investigated retrospectively mean follow period months pre operative symptoms imaging studies including para sagittal mri rotational dynamic intraoperative findings investigated male females age patients ranged years cases intractable occipito cervical pain elicited cervical rotation nerve root block temporally effective unilateral spondylosis symptomatic side without obvious atlatoaxial instability para sagittal mri showed severe foraminal stenosis due bony spur derived lateral atlanto axial joints one case dynamic rotational showed symptomatic foramen became narrower rotational position mcf performed cases nerve root impinged inferior edge posterior arch bony spur joint surgery occipito cervical pain disappeared study demonstrated mechanical impingement nerve root one causes occipito cervical pain successfully treated microscopic resection inferior edge posterior arch para sagittal mri rotational dynamic nerve root block effective diagnosis
paper experimental numerical investigations thin walled beams double box flanges presented continuation researches conducted unit strength materials structures poznan university technology numerical results obtained finite strip method fsm compared experimental ones used validation analytical solutions
nowadays many proposals allow users perform fuzzy queries relational databases regardless proposals fuzzy queries really useful scalar values fuzzy sets adjusted user needs domains non scalar values complex task extend non scalar attribute management fuzzy queries use ontologies thus allow compute kind queries similarity relationships defined explicitly fuzzy set semantically interrelated terms modeled domain ontology well moreover present architecture novel system combines techniques return answer much complete possible ordered degree accomplishment finally qualitative quantitative study use flexible queries relational databases included work well elsevier inc rights reserved
paper static dynamic stiffness rubber subjected compression shear investigated rubber bearing applications static stiffness existing models describe rubber behaviors based linear elasticity assumptions may adequate excessive deformation first part paper modeling rubbers hyperelastic materials utilizing finite element analyses key assumptions classic formula first examined rubber behaviors compression shear simulated found classic formula underestimates stiffness rubber particular rubber high shape factors compression shear stiffness ratio could deviate considerably classic relation typical working strain levels could significantly affect machine performance prediction design hand due viscoelastic nature dynamic stiffness rubber bearings varies working frequencies affecting precision control second part work rubber pads modeled three parameter general maxwell fluids dynamic stiffness evaluation combining original rubber bearing additional elastic flexure even secondary rubber possible change original rubber stiffness compression shear directions finally designs reduce high frequency shear stiffness enhance steady state compression stiffness rubber bearings proposed demonstrated
paper infinite horizon optimal control problem quadratic performance index discrete time multi delay systems addressed classical approach using augmented state space single delay systems extended multi delay case solvability conditions considered state space representation established control system robustness uncertainties formally evaluated optimal solution given state feedback form design equations consistent standard ones undelayed systems thus problem treated existing numerical algorithms solver packages analytical findings illustrated simulation scenario concerning optimal control logistic network
intestinal epithelial cells iecs constantly exposed commensal flora pathogen challenges iecs regulate innate immune response maintain gut homeostasis remains unclear interferons ifns cytokines produced infections type ifn receptors ubiquitously expressed type iii ifn receptors expressed epithelial cells epithelium specificity strongly suggests exclusive functions epithelial surfaces relative roles type iii ifns establishment antiviral innate immune response human iecs clearly defined used mini gut organoids define functions types iii ifns protect human gut viral infection show primary non transformed human iecs upon viral challenge upregulate expression type type iii ifns transcriptional level secrete type iii ifn supernatant however human iecs respond type type iii ifns producing ifn stimulated genes turn induce antiviral state using genetic ablation either type type iii ifn receptors show either ifn independently restrict virus infection human iecs importantly report first time differences mechanisms ifn establishes antiviral state contrary type ifn antiviral activity induced type iii ifn strongly dependent mitogen activated protein kinases signaling pathway suggesting pathway used type iii ifns non redundantly contributes antiviral state conclusion demonstrate human intestinal epithelial cells specifically regulate innate immune response favoring type iii ifn mediated signaling allows efficient protection pathogens without producing excessive inflammation results strongly suggest type iii ifn constitutes frontline antiviral response human gut propose mucosal surfaces particularly gastrointestinal tract evolved favor type iii ifn mediated response pathogen infections allows spatial segregation signaling moderate production inflammatory signals propose key maintain gut homeostasis
integration drive components becoming increasingly desirable global industrial applications end users want ability control speed drivetrain ensuring drive components operate high level reliability safety electric motor variable frequency drive designed operate harmoniously opportunity optimize cost reliability drivetrain package paper provides examples improvements drivetrain component size cost motors drives sized together one package opposed sized separately without consideration paper also provides examples cost ownership due efficiency improvements enhanced taking account entire drivetrain package finally application considerations required ensure drivetrain reliability life installation discussed
anti microtubule drugs paclitaxel ptx extensively used treatment numerous cancers however growing evidence shown ptx resistance either intrinsic acquired frequently occurs patients results failure treatment contributing high cancer mortality rate therefore necessary identify genes pathways involved anti microtubule drug resistance future successful treatment cancers pygopus pygo contains coordinated plant homeodomain phd finger domain critical beta catenin dependent transcriptional switches normal malignant tissues expressed various cancers including human brain glioma study report expression pygo inhibited efficacy ptx contributed cell multidrug resistance two different ways first expression pygo inhibited ptx induced phosphorylation cell lymphoma bcl suppressing proteolytic cleavage procaspase inhibiting activation caspase also inhibits activation jnk sapk pathway ultimately inhibiting cell apoptosis second expression pygo facilitated expression glycoprotein acts drug efflux pump promoting transcription multi drug resistance mdr mdr promoter loci resulting acceleration efflux ptx
background purpose parkinson disease major neurological disorder requires lifelong treatment combined presence helicobacter pylori pylori infection increase required anti medications aim investigate effect pylon infection indian patients methods prospectively recruited patients december january patients underwent detailed neurological evaluation serological examination pylori infection seropositive seronegative patients considered cases controls respectively patients seropositive received triple therapy weeks outcome measures mean unified parkinson disease rating scale updrs iii score mean updrs iii score mean onset time mean duration mean daily time measured baseline week follow results pylori igg positivity present patients prevalence men mean duration disease mean levodopa equivalent daily dose significantly higher among pylon positive patients controls controls significantly longer duration daily time better updrs iii scores seropositive patients took significantly longer time turn oil levodopa challenge week follow pylori eradication significantly improved mean updrs iii score onset time duration daily time conclusions pylon infection present indian patients pylori seropositivity associated poor response levodopa increased medication usage eradication therapy associated better patient outcomes
objective raspberry plants belonging species rubus idaeus known excellent therapeutic properties particularly rich compounds strong antioxidant activity promote health well human cells besides high content phenolic compounds rubus plants rich oil soluble compounds also primary components hydrolipidic film barrier skin plant cell cultures represented valuable system produce interesting compounds ingredients cosmetic applications developed liquid suspension cultures rubus idaeus leaves used obtain active ingredient aimed improving hydration moisturization capacity skin methods rubus idaeus cells grown laboratory sterile controlled conditions liquid suspension cultures processed obtain oil soluble liposoluble extract containing phenolic compounds wide range fatty acids extract tested cultured keratinocytes fibroblasts skin invivo assess cosmetic activities results tested skin cell cultures extract induced genes responsible skin hydration aquaporin filaggrin involucrin hyaluronic acid synthase stimulated expression activity enzyme glucocerebrosidase involved ceramide production moreover liposoluble extract increased synthesis extracellular matrix components cultured fibroblasts showed remarkable skin hydrating capacity tested human skin invivo conclusions thanks activities rubus idaeus liposoluble extract several potential applications skin care cosmetics used hydrating moisturizing ingredient face body lotions anti ageing product face creams specifically designed fight wrinkle formation
domestic rainwater harvesting drwh widely recognized alternative source water taiwan water shortages suggests rainwater potential maximized quantified article assess potential drwh national level consider climatic building characteristic economic ecological aspects drwh propose three categories theoretical available environmental bearable rainwater potential four main steps followed develop proposed framework fifteen rainfall zones across taiwan generated cluster analysis based average annual day rainfall distributions rainfall stations administrative districts roof area rainfall zone estimated using geographic information system gis land use classification database weighted percentage rainwater use rainfall zone determined optimal point storage capacity rainwater supply reliability curve equivalent building building type percentage total roof area used harvest rainwater region depends downstream impact stream flow procedures developed study constitute effective tool preliminarily estimation national drwh potential
part two part paper fundamental concepts interlaminar fault consequences magnetic cores presented equivalent configuration proved fem modelling proposed magnetic cores interlaminar fault part paper based equivalent configuration core equivalent circuit eddy current path analytical model developed estimate eddy current power loss magnetic cores interlaminar faults wide range magnetizing frequency important factors skin effect nonuniform flux density distribution complex relative permeability nonlinear relation often neglected literature highlighted packs two three four epstein size laminations conventional grain oriented shorted together artificially measure extra power loss caused interlaminar fault support analytical modeling found magnetic cores affected interlaminar fault skin effect determinant factor magnetic properties determinations even low frequencies
currently increasing importance attached heavy metal pollution water environment order help geologist environmentalist obtain site experimental data urgent need develop portable analysis techniques water quality used give timely accurate assessment water quality contaminated area low cost monitor water environment conveniently daily preventing controlling work water pollution based adsorption purolite chelating resin thin film sample preparation technique rapid simple site oriented analysis method heavy metal ions namely aqueous solutions developed utilizing handheld energy dispersive ray fluorescence paper correlation coefficients calibration curves greater six metal ions lower limits detection precision tests carried multi element mixed solutions showed relative standard deviations rsd better method used site analysis water samples collected different river well sites near mining area northeast china five underground water samples one found contaminated class one class one class iii surface water samples showed better qualities two sixteen found contaminated heavily class laboratory icpms used analyze samples results coincident site data general higher concentrations site data lower icpms reason might inclusion fine suspending particles samples icpms conclude site data effective described method overall data acquisition time including sampling processing measuring within hours batch samples pre concentration device xrf instrument small light portable operate without external power supply method suitable site water sample analysis especially remote areas
study design eleven patients painful osteoporotic vertebral fractures underwent kyphoplasty using calcium phosphate cap cement followed week years monocentric nonrandomized noncontrolled retrospective trial objective study investigates long term radiomorphologic features intraosseous cap cement implants extraosseous cap cement leakages years implantation kyphoplasty summary background data kyphoplasty frequently used treatment painful osteoporotic fractures materials available cap frequently used filling material resorption material frequently observed although clinical outcome comparable cements methods kyphoplasty utilizing cap cement performed patients painful osteoporotic vertebral fractures patients received pharmacological antiosteoporosis treatment consisting calcium vitamin standard dose oral bisphosphonates radiomorphologic measurements pain mobility assessed results intraosseous extraosseous cap cement volumes decreased significantly years however vertebral stability determined constant vertebral body height sagittal index impaired pain improved significantly years implantation mobility scores year kyphoplasty least third year conclusions intravertebral cap cement implants resorbed slowly time without jeopardizing stability clinical outcomes likely slowly progressing osseous replacement extraosseous cap cement material leakages kyphoplasty procedure almost completely resorbed early years leakage occurred therefore cap cement important alternative pmma based cement materials utilized kyphoplasty osteoporotic vertebral fractures
togo otsuka goto furuse yasuo photoperiod regulates dietary preferences energy metabolism young developing fischer rats age wistar rats physiol endocrinol metab first published july doi ajpendo effects photoperiod dietary preference examined using young growing fischer wistar rats seasonal nonseasonal breeders respectively rats provided low fat high carbohydrate diet lfd energy carbohydrate fat protein high fat low carbohydrate diet hfd energy carbohydrate fat protein simultaneously long light day shortday light day conditions fischer rats preferred lfd hfd condition whereas preference diets equivalent condition consequently body weight total energy intake exhibited increases respectively condition calculation energy intake macronutrients revealed rats condition consumed higher energy carbohydrates proteins respectively condition contrast wistar rats preferred lfd hfd irrespective photoperiod exhibited photoperiodic changes parameters examined next fischer rats provided either lfd hfd conditions calorie intake higher rats fed lfd fed hfd condition however rats condition exhibited increases body weight epididymal fat mass plasma leptin levels respectively compared condition irrespective dietary composition conclusion photoperiod regulates feeding energy metabolism young growing fischer rats via interactions dietary macronutrient composition
study effective means dewatering dredged material obtained sea bottom istanbul investigated use additives geotextile tubes also known geotubes geotextile containers geotextile bags rapid dewatering test geotube dewatering test laboratory approaches types amounts anionic cationic additives dewatering efficiency dredged sludge quickly economically examined study best dosage amount tonne used flocculant solution preparation distilled water process twelve homogeneous sludge polymer admixtures prepared adding polymers anionic cationic weight dredged material rapid dewatering tests another twelve homogeneous sludge polymer admixtures prepared adding polymers anionic cationic weight dredged material geotube dewatering tests results indicated golden horn dredged sludge could successfully dewatered retained geotextile tubes use chemical cationic polymers recommended golden horn dredged sludge rather anionic polymers results also showed use flocculants significantly increase retention capacity geotubes
paper aims investigate experimentally theoretically electromechanical dynamic interaction driving stepping motor driven laboratory belt transporter system test rig imitates operation robotic device form working tool carrier translational motion object consideration equipped measurement systems enable registration electrical mechanical quantities analytical considerations performed means circuit model electric motor discrete non linear model mechanical system various scenarios working tool carrier motion positioning belttransporter measured simulated cases electric current control driving motor applied main goal study investigate influence stepping motor control parameters along various mechanical friction models precise positioning laboratory robotic device elsevier ltd rights reserved
previous studies identified elevations antibodies toxoplasma gondii individuals history suicide attempts studies measured association suicide attempts panel antibody markers assessed patients receiving treatment schizophrenia bipolar disorder major depression columbia suicide severity rating scale suicide attempt history clinical measures participants blood sample drawn measured antibodies toxoplasma gondii neurotropic infectious agents total participants lifetime suicide attempt individuals elevated levels igm class antibodies toxoplasma gondii cytomegalovirus cmv also found association levels antibodies number suicide attempts particularly strong odds suicide attempt history individuals elevated levels igm antibodies toxoplasma gondii cmv suggesting additive risk associated antibodies findings remained significant adjusting current cigarette smoking history drug alcohol use also associated suicide attempts find association suicide attempt history igg class antibodies toxoplasma gondii cmv igm igg antibodies epstein barr virus antigens tested identification blood based antibody markers provide personalized methods assessment treatment ultimately prevention suicide attempts individuals serious mental illnesses elsevier ltd rights reserved
proteolytic processing amyloid precursor protein app terminal fragments ctfs gamma secretase underlies pathogenesis alzheimer disease rna interference screen using app ctf residue ctf notch specific gamma secretase interaction assays identified unique erbb centered signaling network predicted preferentially govern proteostasis app consistently significantly elevated levels erbb confirmed hippocampus human brains found erbb effectively suppressed autophagic flux physically dissociating beclin vps vps complex independent kinase activity regulation erbb decreased levels secreted amyloid beta cellular zebrafish mouse models activation autophagy oral administration erbb targeted significantly improves cognitive functions app presenilin transgenic mice work unveils noncanonical function erbb modulating autophagy establishes erbb therapeutic target
hypertension metabolic syndrome major problems africa role sex hormones cardiovascular profile black africans south africa studied objective study association sex hormones ambulatory blood pressure heart rate black white south africans hour ambulatory blood pressure measurements performed blood samples taken hours total black white south african teachers years age similar socioeconomic backgrounds sympathetic activity ambulatory blood pressure africans sabpa study included result vulnerable cardiovascular profile observed africans compared caucasians african group low testosterone explained variance systolic blood pressure sbp diastolic blood pressure dbp whereas caucasian group non sex hormone binding globulin non shbg bound explained variance african males inverse associations blood pressure sbp dbp non shbg bound sbp dbp observed ambulatory predicted prediabetic state africans conclusion low levels may predispose result impaired cardiovascular function african men possibility exists prediabetic state vagal impaired hyperkinetic blood pressure responses may predispose result low levels african men
field network security researchers implemented different models secure network intrusion detection system also one snort open source tool intrusion detection prevention system today intrusion detection system growing technology network security mostly researchers focused field used signature rule based technique anomaly based techniques improve security network paper propose rule base intrusion detection system self generated new efficient port scan detection rules epsdr rules used detect naive port scan attacks real time network using snort basic analysis security engine base base used view snort results font end web page snort graphic user interface rule based intrusion detection system match signature efficient port scan detection rules epsdr captured packet definition signature based ids new epsdr based ids useful reduce false positive alarm
known magnetic force due closed circuit weber force law identical lorentz force law investigation shown electric magnetic force quasi static case riemann force law identical lorentz force law former based oil potential energy depending relative speed accord newton law action reaction
social relationships graph sociogram allows transparent view people surroundings certain relationship options already depicted many tools generally use data social networks facebook google certainly every graph entirely transparent usable sociogram contains large number vertices edges larger number people surroundings possible simply work graph subsequently describe article introduce options make sociogram transparent thus offering easier work work software tool ihmc company called cmaptools normally operates desktop operating systems case working version android externally developed company long time yet publicly introduced
aims primary aim study analyse conformance usual care patterns persons schizophrenia treatment guidelines three italian departments mental health dmhs secondary aim examine possible organisational structural reasons accounting variations among dmhs methods within framework evaluation treatment appropriateness schizophrenia etas project consensus quality care indicators developed ten concerned pharmacological treatment ten encompassed general care psychosocial rehabilitation interventions indicators calculated using data stratified random sample patients treated three dmhs located north eastern north western southern italy patients data collected combining information medical charts survey carried health care professionals charge patients data structural organisational characteristics dmhs retrieved administrative databases indicator number percentage appropriate interventions without moderators calculated appropriateness defined percentage eligible patients receiving intervention conformant guidelines moderators reasons justifying discrepancy interventions actually provided recommended guidelines recorded indicators based sufficient number eligible patients explored statistical analysis compare performance dmhs results overall sample percentage inappropriate interventions ranged non pharmacological interventions pharmacological interventions comparisons among dmhs revealed significant variability appropriateness indicators prevention monitoring metabolic effects psychiatric visits psychosocial rehabilitation family involvement work adjusting patient gender age functioning indicators prevention monitoring metabolic effects psychiatric visits work continued differ significantly among dmhs percentage patients receiving appropriate integrated care least one appropriate non pharmacological intervention one pharmacological intervention significantly different among three dmhs lower expected conclusions results underscore discrepancies among italian dmhs indicators explore key aspects care patients schizophrenia use quality indicators improved guideline adherence address suboptimal clinical outcomes potential reduce practice variations narrow gap optimal routine care
aim background dipyridamole induced stress myocardial perfusion scans mps widely used management coronary artery disease adverse effects dipyridamole stress agents evaluated aim research confirm dynamic data dipyridamole side effects mps methods collected data patients underwent dipyridamole induced stress mps retrospectively reviewing clinical records included severity dipyridamole side effects min min min infusion incidence severity three points including effect age gender obtained results adverse effects occurred patients frequent symptoms dizziness chest tightness abdominal pain headache symptoms grade according grading system common terminology criteria median duration symptom persistence min significantly different among age gender conclusion study demonstrates adverse effects dipyridamole generally minimal duration acceptable clinical usage author published elsevier ireland ltd open access article license http creativecommons org licenses
aim paper analyze proportion variance prosociality aggressiveness predicts positive emotions joy gratitude serenity personal satisfaction empathy perspective taking empathic concern social self efficacy since abundant research showing significant differences prosocial behavior aggression sex separate analyzes performed children sample consisted children sexes males years middle class attended primary schools city buenos aires argentina results indicate empathy positive emotions involved predicting prosocial behavior boys girls however seems clear case boy empathy greater predictive power positive emotions unlike girls variables seem share similar power hand social self efficacy predicts prosocial behavior girls finally results indicated empathy positive emotions inhibit aggressive behavior girls
research consistently indicated higher levels materialism associated reduced wellbeing currently studies examined underlying epistemic metaphysical factors may contribute materialism wellbeing current study used structural equation modelling investigate indirect influence epistemic style holistic mechanistic perspectives wellbeing via materialism regulation first study indicated epistemic orientation towards complex intellective position rather expedient effortless default position thinking directly associated reduced materialism resulted greater autonomous regulation subsequently increased wellbeing findings replicated second study also suggested higher levels holism indirectly associated increased wellbeing elsevier ltd rights reserved
digital visualization technology new research field along rapid development computer technology multi scale technology consists computer graphics image information processing computer aided design paper research development products innovation design method thereby realize innovation product design rapidly time verify feasibility practicality broad application prospect applying scan technology rapid development design manufacture products
first part paper describes mechanical structure rttrr small sized modular robot second part reserved determination geometric model robot using method rotation matrices third part presents kinematic model determined using iterative method kinematic modeling equations geometric kinematic models determined help first three modules generalized modeling application robot symbolic useful simulation geometric kinematic behavior analyzed robot
introduction allergy results aberrant type inflammatory response triggered wide range environmental antigens allergens lead various immune responses culminating production immunoglobulin ige two key cytokines interleukin critical induction perpetuation type response implicated multiple atopic diseases area covered review summarizes recent milestone developments elucidated components pathogenesis atopic diseases atopic dermatitis asthma chronic sinusitis nasal polyposis cswnp expert commentary several therapeutic agents selectively target potentiators type pathway shown efficacy one atopic diseases agents proven broadly applicable across three atopic diseases dupilumab human monoclonal antibody simultaneously inhibits signaling demonstrated significant clinical efficacy asthma cswnp fact diseases often occur comorbidities respond therapy suggests common underlying pathogenic pathway cytokines central regulating pathogenesis atopic diseases
keen interest identifying specific brain regions related individual differences true false memories previous functional neuroimaging studies showed activities hippocampus right fusiform gyrus parahippocampal gyrus associated true false memories study thus far examined whether structures brain regions associated short term long term true false memories address question current study analyzed data healthy young adults valid data structural brain imaging misinformation task misinformation task subjects saw crime scenarios received misinformation took memory tests crimes hour later years results showed bilateral hippocampal volume associated short term true false memories whereas right fusiform gyrus volume surface area associated long term true false memories study provides first evidence structural neural bases individual differences short term long term true false memories
clusters cpu mic heterogeneous architecture becoming popular recent years however easy achieve good performance machines key challenge asymmetry within clusters arising different kinds execution units well different communication latencies improve performance large scale structural analysis cpu mic heterogeneous clusters multi layer multi grain collaborative parallel computing approach proposed paper proposed method combines parallel algorithm hardware architecture cpu mic heterogeneous clusters together mapping computing tasks various hardware layers resolves load balance problem cpu mic devices significantly reduces communication overheads system numerical experiments conducted tianhe supercomputer show proposed method obtained better performance compared traditional approach scalability investigation showed proposed method good scalability respect problem sizes findings paper help parallel porting performance optimization applications cpu mic heterogeneous clusters
one used cephalosporins clinical practice cefuroxime axetil anaphylaxis due administration cefuroxime considered rare event report case anaphylactic reaction administration cefuroxime child tolerated drug past exposures diagnostic workup recommended patients least moderate anaphylactic reaction hypotension tachycardia bronchial hyperreactivity include detailed history event previous allergies underlying conditions unfortunately currently available diagnostic approaches ige skin prick test tryptase leave significant percentage non diagnostic results false positive negative outcomes
axial flux machines featured compact size high performance suitable powertrains electric vehicles paper studies design control totally enclosed axial flux integrated starter generator system torque density volume benefits large number pole pairs designing machines however increased pole pair number decreases switching frequency electrical period ratio large power drives troubled limited switching frequency improve situation control strategy named overmodulation technique variable sampling frequency proposed improve system performance nonlinear region heat dissipation potential inverter fully utilized bus voltage utilization ratio enhanced control strategy simulation results carried current waveform also improved
synthesis procedure general nth order allpass voltage transfer functions using solely voltage differencing buffered amplifiers vdbas capacitors signal flow graph design method described shown proposed structure employs vdbas capacitors realization nth order voltage transfer function illustrative example third order voltage mode allpass filter designed simulated using pspice
importance etiology recurrent croup often anatomic currently set criteria determining undergo diagnostic bronchoscopy patients risk clinically significant finding studies addressed questions objective identify risk factors clinically significant findings bronchoscopy children recurrent croup frequency bronchoscopy findings general data sources pubmed ovid medline embase study selection articles addressing bronchoscopy children recurrent croup july reviewed related keywords medical subject headings used search abstracts reviewed determine suitability inclusion based set criteria manual crosscheck references performed data extraction analyzed bronchoscopy findings individual patients study associated risk factors available results reviewed articles published including patients males females studies including patients sufficient data meta analysis study revealed three common bronchoscopy findings subglottic stenosis reflux changes broncho tracheomalacia patients noted clinically significant findings bronchoscopy meta analysis showed association significant bronchoscopy findings history intubation inpatient consultation age age prematurity study found high incidence history gerd asthma allergies among patients recurrent croup variables reach statistical significance patients significant bronchoscopy findings respectively conclusion risk factors associated clinically significant bronchoscopy findings recurrent croup intubation inpatient consultation age age prematurity history gerd asthma allergy though highly prevalent recurrent croup patients statistically associated significant bronchoscopy findings relevance results guide physicians selecting recurrent croup patients risk significant findings thus may warrant bronchoscopy elsevier ireland ltd rights reserved
study periodic solutions suspension bridge model proposed lazer mckenna periodic damping term dolph type condition small periodic damping term condition existence uniqueness periodic solution proved constructive method two numerical examples presented illustrate effect periodic damping term
recent rapid growth aquaculture industry necessity comply environmental standards suggest need studies possible negative effects type industry one devastating effects aquaculture water pollution caused discharge untreated effluent fish farms aquatic ecosystems assessment pollutants requires optimal design water monitoring network way demonstrate changes aquatic environments accordingly present study used multivariate statistical analysis determine sampling frequency optimal monitoring contaminants resulting trout farms haraz river northern iran purpose total number physical chemical water quality parameters sampled monthly one year period based instructions recommended standard method results showed changes biochemical oxygen demand bod warm months summer high reached peak august september may attributed increased fish production fish farms increased food intake feed fish higher rate discharge fish farms containing waste feed fish faeces nitrate also reached maximum level june due reasons conversely dissolved oxygen level lowest warm months august september reason would increased consumption due higher production rate fish farms increased metabolism fish warm months overall findings confirmed applicability multivariate techniques determining temporal frequency measurements monitoring period would possible recognize reality changes water quality fewer measurements less time cost
influence external circuit designs aset shapes high speed current feedback amplifier cfa investigated means pulsed laser single event effect plsee simulation technique changes feedback resistors modify circuit electrical parameters closed loop gain bandwidth affecting amplifier stability aset shapes qualitative explanations based general electronic rules feedback theories enable understanding cfa operation establishing correlation evolution external feedback resistor values aset parameters tid effects aset sensitivity cfa also investigated work highlighting different behaviors according impacted bipolar transistor integrated circuit
introduction epstein barr virus ebv ubiquitous herpesvirus associated number clinical manifestations primary ebv infection young adolescents often manifests acute infectious mononucleosis latent infection associated multiple lymphoid epithelial cancers autoimmune disorders particularly multiple sclerosis areas covered last decade understanding pathogenesis immune regulation ebv associated diseases provided important platform development novel vaccine formulations review discuss developmental strategies prophylactic therapeutic ebv vaccines assessed preclinical clinical settings expert commentary major roadblocks ebv vaccine development include precise understanding clinical correlates protection uncertainty adjuvant selection unavailability appropriate animal models recent development new ebv vaccine formulations provides exciting opportunities formal clinical assessment novel formulations
expected growth distributed generation significantly affect operation control today distribution grids confronted fast fluctuating power distributed generations assurance reliable service grid stability avoidance energy losses quality power may become costly light smart grids may provide answer towards active efficient electrical network project smartcnet aims enable smart grid operations imperfect heterogeneous general purpose networks poses significant challenge reliability due stochastic behaviour found networks therefore key concepts presented paper targeting support proper smart grid control network environments real time hardware loop hil verification overview required information communication technology ict architecture functionality provided description relevant use case deals voltage control medium low voltage networks along evaluation approach experimental test bed detailed
using data collected canada united states united kingdom article examines determinants attitudes toward immigrants particular draw literature social psychology explore role locus control promoting ethnocentric restrictive attitudes towards immigration conceptualize control three levels perceptions individual locus control feeling one control one circumstances perceptions societal control feeling one country control immigration perceptions outgroup locus control feeling outgroup social circumstances attributable dispositional rather external factors results show three measures control important predictors negative attitudes toward immigrants feel control personally society less hostile towards immigrants attribute negative outcomes immigrants predispositions also hostile results also suggest measures control related distinct partisanship racial prejudice
among many scientific advances come study nanoscience development ligand targeted nanoparticles eliminate solid tumors predicted major impact human health many reports describing novel designs testing targeted nanoparticles treat cancer principles technology well demonstrated controlled lab experiments still many hurdles overcome science mature truly efficacious targeted nanoparticles join arsenal agents currently used treat cancer humans one hurdles overcoming unwanted biodistribution liver maximizing delivery tumor almost certainly requires advances nanoparticle stealth technology targeting currently continues challenge control loading ligands onto polyethylene glycol peg achieve maximal targeting nanoparticle cellular uptake subcellular targeting genes sirna also remain challenge review examines types ligands often used target nanoparticles solid tumors science matures coming decade careful control ligand presentation nanoparticles precise size shape charge likely play major role achieving success
implementing cloud computing empowers numerous paths web based service offerings meet diverse needs however data security privacy become critical issue restricts many cloud applications one major concerns security privacy caused fact cloud operators chances reach sensitive data concern dramatically increases users anxiety reduces adoptability cloud computing many fields financial industry governmental agencies paper focuses issue proposes intelligent cryptography approach cloud service operators directly reach partial data proposed approach divides file separately stores data distributed cloud servers alternative approach designed determine whether data packets need split order shorten operation time proposed scheme entitled security aware efficient distributed storage eds model mainly supported proposed algorithms including alternative data distribution adz algorithm secure efficient data distributions sed algorithm efficient data conflation edcon algorithm experimental evaluations assessed security efficiency performances experimental results depict approach effectively defend main threats clouds requires acceptable computation time elsevier inc rights reserved
objective evaluate performance smartphone based hearing screening hearscreen application terms sensitivity specificity referral rates time efficiency two primary health care clinics design nonprobability purposive sampling used clinics total participants mean age range years female included final analysis participants screened using hearscreen application following two step screening protocol diagnostic pure tone audiometry confirm hearing status results sensitivity specificity smartphone screening respectively positive negative predictive value respectively sex chi race chi significant effect screening outcome children adults age beta sex beta significant effect screening outcomes males likely fail overall referral rate across clinics initial screening test times less minute seconds adults slightly minute children seconds conclusions hearscreen smartphone application provides time efficient identification hearing loss adequate sensitivity specificity accurate testing primary health care settings
purpose paper aims contribute entrepreneurship theorising highlighting salience feminine caring positions creating novel entrepreneurial roles investigating roles contribute community resilience using critical feminist economics lens alternative conceptualisations economy expanded upon reveal economic externality influences entrepreneurial discourse gender roles community resilience design methodology approach interpretive approach empirical evidence drawn six months intensive ethnographic research tourism handicraft micro entrepreneurs crete epirus greece hence context macroeconomic crisis ethnographic interviewing participant observation used methods achieve research objectives findings thematic analysis used investigate gender roles entrepreneurial roles interact interaction influences community resilience economic crisis using critical theory critique neoclassical economics interpretations entrepreneurship becomes evident politico economic structures perpetuating feminised responsibility social reproduction configure feminine entrepreneurial roles roles positive effect increasing community resilience conceptualising entrepreneurial involvement primarily community gain participants highlight feminine entrepreneurial discourse differs neoclassical economics entrepreneurial discourse entrepreneurial involvement primarily individual gain social implications paper contributes theoretical advancements role gender entrepreneurship community resilience investigating entrepreneurs gendered responses exogenous shock providing insight role gender entrepreneurial adaptation sustainable business practices means new policies combat social exclusion promote rural development formulated originality value theoretical interplay gender entrepreneurship investigated novel angle critical feminist economics relationship feminised interpretations entrepreneurship community resilience brought light providing unique insight entrepreneurial resilience
decentralized energy supply frequently discussed topic german industry caused continuously rising energy prices study assesses configurations hybrid renewable energy systems hres regard ability decrease company energy supply costs apply mixed integer linear programming milp optimize electricity heat supply system aim minimizing annual costs perform energy system optimizations sample three case studies virtual companies results show systems consisting grid supply combined heat power plants chp heat storage facilities cases photovoltaics lower sample companies annual energy costs average including annualized investments time frame years average internal return rate hres investments work expands body literature hres optimizations shifting research focus household industrial supply model support corporate investment decisions decentralized supply facilities published elsevier ltd
orth trzesniewski robins concluded nationally representative americans changing lives acl cohort sequential study demonstrated moderate large age differences self esteem birth cohort generational differences age trajectory reanalysis data using different statistical techniques find significant increases self esteem could attributed birth cohort time period first hierarchical linear modeling analyses birth cohort continuous variable multiple group formulation used orth find birth cohort measurable influence self esteem interaction age participants born later years higher self esteem likely increase self esteem aged participants born earlier years however estimated age trajectory age similar orth results results analyses including cohort second comparing acl respondents age versus time lag design yields significant birth cohort differences self esteem participants age higher self esteem combined previous studies finding significant increases self esteem positive self views time results suggest cultural change form cohort time period ignored influences cross sectional longitudinal studies
fracture clinical manifestation osteoporosis one main causes functional limitations chronic pain patients osteoporosis muscle coordination training recommended patients general measures inquired whether sling training better traditional physiotherapy relieving pain improving abilities daily living fifty patients osteoporosis divided two groups group performed conventional physiotherapy group performed sling training exercises data collected intervention months registered parameters stamina posture pain posture torques associated strength spinal muscles studied biomechanical model order estimate forces acting spine furthermore factors exerted positive impact success therapy registered forty four patients completed study positive effects training noted groups significantly better effects observed group performed sling training reduction pain independent number fractures significantly reduced torques reduced muscle strength registered specific training programs helped increase muscle strength straightening back thereby reducing force needed permanent basis decreasing torque spine sling training effective traditional physiotherapy
mining activities among major culprits wide occurrences soil water pollution pahs coal district resulted ecological fragilities health risk local residents sixteen pahs multimedia environment heshan coal district guangxi south china measured aiming investigate contamination level distribution possible sources estimate potential health risks pahs average concentrations pahs coal coal gangue soil surface water groundwater respectively additionally higher soil water pah concentrations detected vicinities coal coal gangue dump composition analysis isomeric ratio pearson correlation analysis principal component analysis performed diagnose potential sources pahs different environmental matrices suggesting dominant inputs pahs coal coal combustion coal gangue soil water soil water guidelines incremental lifetime risk iclr used assess health risk showing soil water heavily contaminated pahs mean iclrcoal coal gangue mean iclrsoil significantly higher acceptable levels posing high potential carcinogenic risk residents especially coal workers study highlights environmental pollution problems public health concerns coal mining particularly potential occupational health hazards coal miners exposed heshan
nitrogen fertilizers critical today agriculture especially united states leaching methane nitrous oxide emissions fertilizer use implications global climate water pollution raised serious concerns among environmentalists agronomists prices fertilizers increased geometrically past years projected increase maize zea mays ethanol production expected increase fertilizer demand prices hay prices however staggering producers looking alternatives fertilizers review paper assessed trends fertilizer use prices well factors affecting fixation transfer dinitrogen forage production systems additionally economic implications using fertilizers grass legume mixtures discussed review apparent legumes potential replace fertilizers least complement use fertilizers forage production systems however transfer forage production systems low lot research needed answer question legumes fix much transfer small proportion crops similarly identifying compatible grass legume species enhance fixation giant step towards reduced fertilizer use ensuring environmental sustainability sharp increase fertilizer prices use legumes forage production systems seems promising
ipv designed solve issue adopting ipv addresses presenting large number address spaces currently many networking devices consider ipv supportive ipv enabled device includes routers notebooks personal computers mobile phones security increasingly become significant issue exploiting networks obtaining benefits ipv one important protocols ipv implementation used neighbor router discovery icmpv however protocol used attackers deny network services icmpv ddos flooding attacks decrease network performance solve problem study proposes intelligent icmpv ddos flooding attack detection framework using back propagation neural network viids ipv networks study also explores analyzes detection accuracy proposed viids framework effectiveness viids framework demonstrated using real data sets obtained nav laboratory data set traffic based test bed environment created basis certain parameters used inputs generate new data set results prove proposed framework capable detecting icmpv ddos flood attacks detection accuracy rate
theoretical study reviews two cited profiles intimate partner batterers scientific literature paying special attention notable differences diem well common criteria study also discusses one longest standing controversies various research studies including particular overview respect spain constant yet erroneous reference equivalence psychopathy antisocial personality disorder similarly special attention paid implications considering intimate partner batterers either psychopathological psychopathic profile also stressing specific role played psychopathy intimate partner batterer concerning psychopathic intimate partner batterers aspects specific motives perpetrating intimate partner violence evaluation instruments particular profile finally series future directives research concerning psychopathic intimate partner batterers also pointed
compliance increasing requirements final product often constitutes challenge manufacturing metal parts common problem represents precise reproduction geometrical form reasons form deviation varying properties semi finished product well wear punch bending machine punch bending tool themself usually process parameters manually adjusted introduction new production scenario deviation actual form produced pieces designed form become clear choice new process parameters normally based experience machine operators leads time consuming expensive procedure right early stages production scenarios well established production process furthermore trend miniaturization part sizes along narrowing tolerances increase strengths materials drastically pushes requirements production process aiming reduction scrap rate setup time production scenarios model based approach chosen design self correcting control strategy strategy designed modeling bending process first step bending process analyzed model varying process variables influencing process significantly done corresponding simulations correlations significant variables geometrical deviation defined different self correcting control strategies designed tested order identify validate simulation test quality self correcting control strategies special experimental tool built experimental tool equipped additional measurement device operated universal testing machine finally self correcting control strategies tested real production conditions original tool order address influences punch bending machine manufacturing process
paper effects occur parts internal combustion engine turbocharger tested critical lubrication conditions low pressure lubrication system reduced oil flow axial bearing lubrication interruption purpose tests obtain evidence damage different parts turbochargers failed tests controlled parameters work contribution generated identify causes failures occur turbochargers identification fault generate contribution possible improvement design different parts turbochargers contribute improving management control internal combustion engines avoid faults
paper presents experience developing professional ethics approach integrates knowledge teaching methodologies assessment coherently implemented students software engineering computer engineering degree programs technical university madrid professional ethics studied part required course contribution paper model formative assessment clarifies learning goals enhances results simplifies scoring replicated contexts quasi experimental study involves many students required course developed test effectiveness teaching process analysis ethical dilemmas use deontological codes integrated scoring rubric designed currently model also used develop skills related social responsibility sustainability undergraduate postgraduate students diverse academic context
objective test cumberland ankle instability tool cait item point scale measuring severity functional ankle instability design cross sectional study setting general community participants volunteer sample subjects interventions applicable main outcome measures concurrent validity comparison lower extremity functional scale lefs visual analog scale vas global perception ankle instability using spearman construct validity internal reliability rasch analysis using goodness fit statistics items subjects separation subjects correlation items total scale cronbach equivalent discrimination score functional ankle instability maximizing youden index tested sensitivity specificity test retest reliability intraclass correlation coefficient model icc results significant correlations cait lefs rho vas rho item reliability index threshold cait score youden index sensitivity specificity test retest reliability excellent icc conclusions cait simple valid reliable tool measure severity functional ankle instability
background day care designed people dementia aims increase users quality life qol objective study compare qol people dementia attending day care attending day care methods study based baseline data project using quasi experimental design including group day care users comparison group receiving day care quality life alzheimer disease qol used primary outcome collect self reported proxy based information family carers users qol linear mixed model used examine differences groups results attending day care significantly associated higher mean scores self reported qol difference groups proxy reported qol analyses interaction group belonging awareness memory loss revealed participants shallow awareness attended day care significant higher mean scores qol compared attending day care conclusions higher self reported qol found among people attending day care designed people dementia compared comparison group difference qol ratings found group day care users shallow awareness memory loss hence day care designed people dementia might potential increase qol experienced users
purposes computer graphics developed simulation tool model fluid flow surface sphere inclusion control parameters benefit art directability difficulties associated use spherical coordinates surmounted use locally modified consistent equations result analysis singular equations neighborhood poles resulting system solved efficiently small additional cost compared two dimensional planar simulation
paper homomorphic visual cryptographic scheme hvcs proposed proposed hvcs inherits good features traditional vcs loss tolerant threshold simply reconstructed method simply reconstructed method means decryption secret image based human visual system hvs without cryptographic computation addition proposed hvcs support signal processing encrypted domain sped homomorphic operations authentication protect user privacy well improve security applications cloud computing theoretical analysis simulation results demonstrate effectiveness security proposed hvcs
introduction mirabegron established alternative monotherapy antimuscarinics treatment overactive bladder oab symptoms initial studies focused western populations past years populations subpopulations evaluated areas covered authors knowledge literature used develop manuscript alongside pubmed search mirabegron clinical trial overactive bladder select independent studies mirabegron date information provided recent mirabegron clinical trial real world efficacy safety tolerability data variety patient populations oab including different geographic areas men elderly poor tolerability antimuscarinics expert commentary improvements efficacy parameters patients oab mirabegron doses approved clinical use day also associated clinically meaningful benefits according patient reported outcomes mirabegron favorable safety tolerability profile particularly compared antimuscarinics dry mouth constipation many cns effects maintained year growing body evidence suggests mirabegron represents new treatment option broad range patients oab
different types serious games used elucidating computer science areas computer games mobile games lego based games virtual worlds web based games different evaluation techniques conducted like questionnaires interviews discussions tests simulation widely used computer science motivational interactive learning tool paper aims evaluate possibility successful implementation simulation computer programming modules framework proposed measure impact serious games enhancing students understanding key computer science concepts experiments held eeecs queen university belfast students test framework attain results
activation osteoclasts directly responsible pathological bone loss conditions rheumatoid arthritis cancer metastasis bone hypoxia common feature conditions associated poor prognosis also stimulates osteoclast mediated bone resorption via induction hypoxia inducible transcription factor hif alpha investigate effects fibroblast growth factor fgf osteoclast function fgf intracellular fgf induced hypoxia inhibition hif regulating prolyl hydroxylase enzymes cocl osteoclasts isoform specific sirna demonstrated induction fgf mrna expression hypoxia hif alpha dependent hypoxic stimulation bone resorption inhibited osteoclasts treated sirna targeting fgf least partially due reduced secretion unidentified pro resorptive factor downstream fgf fgf expression within hypoxic resorbing osteoclasts localised microtubule associated alpha tubulin fgf also abundantly expressed osteoclasts within rheumatoid synovium giant cell tumour bone study suggests fgf novel factor driving pathological bone resorption osteolytic disease potential target development new anti resorptive therapeutic agents
degradation urban river ecosystems presents serious threat sustainable urban development consequently extensive efforts devoted ecological restoration urban rivers worldwide study evaluates environmental externalities associated water pollution river restoration guangzhou southern china basic hedonic pricing model applied test hypotheses using sample apartment transaction records july december results show river restoration could reverse negative externalities polluted watercourses positive externalities especially apartments located floor lower water quality improvement polluted non recreational water grade worse non body contact recreational water grade could increase apartment values river restoration including river bank greening water quality improvement could increase property values demonstrating preference guangzhou residents greening riverscapes study could hopefully provide scientific basis urban river governance communities decision makers serve reference case elucidate human preferences river restoration rapidly developing countries elsevier rights reserved
paper proposes calibrates consistent multi factor affine term structure mortality model longevity risk applications show model appropriate fitting historical mortality rates without traded mortality instruments choice risk neutral measure unique fit observed historical mortality rates framework show risk neutral parameters calibrated relatively insensitive historical period chosen importantly framework provides consistent future survival curves parametric form initial curve risk neutral measure multiple risk factors allow applications pricing general risk management problems state space representation used estimate parameters model kalman filter measurement error variance included age capture effect sample population size swedish mortality data used assess factor implementations model factor model specification shown provide good fit observed survival curves especially older ages bootstrapping used derive parameter estimate distributions residual analysis used confirm model fit use heath jarrow morton forward rate framework verify consistency simulate cohort survivor curves risk neutral measure elsevier rights reserved
power area efficient metal oxide semiconductor field effect transistor mosfet bit fully differential pipelined analog digital converter adc stage proposed designed tsmc digital cmos technology supply voltage based charge pump based technique achieve stage voltage gain various capacitances implemented moscaps capacitance offered mosfet offering compatibility cheaper digital complimentary metal oxide semiconductor cmos process order reduce much required manufacturing cost proposed stage suffers linear gain error full signal swing peak peak differential using proposed stage calibrated signal noise distortion ratio sndr spurious free dynamic range sfdr bit pipelined adc respectively increased using simple digital calibration technique comparison proposed stage conventional operational amplifier based stage shows insensitivity towards capacitor mismatch along power savings design simplicity
concerns human machine interaction becoming one important thrusts development innovative successful products interaction design methods tools already described literature available designers analysis characteristics suggests synergy research fields aimed developing interaction design framework complete possible complementary aspects inventive problem solving theory named triz considered linking done thanks structured approach information gathering house quality one data structures quality function deployment qfd design method result interaction design guidelines idgl framework implemented microsoft access database supports designers starting collecting users needs generation design solutions paper describes idgl development together first adoption field validation process results
turbocharger compressor working commercial vehicles especially passenger cars often works together pipes complicated geometry air intake system due limit available space internal combustion engine compartments pipes may generate various distortions physical parameters air inlet compressor therefore compressor aerodynamic performance deteriorates sometimes turbocharging engine fails work operation points paper investigates effects various swirl distortions induced different bending torsional intake ducts aerodynamic performance turbocharger compressor numerical simulations experimental measurements found outlet pipes different inlet ducts generate different swirl distortions twin vortices bulk like vortices different rotating directions among bulk like vortices affect seriously pressure distribution impeller domain also significantly deteriorate compressor performance especially high flow rate region rotating direction bulk like vortices also closely associated efficiency penalty besides efficiency transient flow rate single impeller channel asymmetric mass flow crossing whole impeller influenced two disturbances one upstream bending torsional ducts one downstream volute
response habituation fundamental form nonassociative learning yet substantial individual differences electrodermal manifestation employed latent class analysis identify discrete groups electrodermal responders series loud tones also evaluated whether heterogeneity responsiveness associated lifetime prevalence externalizing psychopathology major depression participants community recruited men underwent standard habituation paradigm latent class analysis resulted identification four electrodermal populations rapid habituators habituators two classes showed weak response habituation differed markedly amplitude profiles relative rapid habituators members slower habituating classes less likely receive lifetime diagnoses antisocial personality disorder substance dependence research using analytical strategy could help identify functional significance individual differences habituation
massive amounts information others disclosed across world social network sites every day disclosure information others may precipitate unanticipated consequences violating privacy another individual previous social network site sns research examined self disclosure research examines disclosure information others dio building upon theory planned behavior lens rest ethical derision making model person concern others privacy cop wants share information different concern authors tested posited model using data collected survey instrument findings show cop attitude toward using snss influence intention disclose information others also cop explained social identity agreeableness extraversion opinion leadership sensitive information disclosure control prior privacy invasions social norms influence intentions disclose information others results indicate males higher concern others privacy females research contributes understanding ethical choices information disclosure within snss findings help sns developers improve privacy practices protect sensitive third party information improve user satisfaction published elsevier ltd
sacral neuromodulation snm fda approved treatment option several refractory pelvic floor disorders given efficacy safety profile past several years numerous papers published snm long term outcomes emerging new indications comparisons treatment options cost effectiveness therefore aim review updates snm literature pubmeda medlinea search performed scientific publications sacral neuromodulation sacral nerve stimulation recent evidence shown improved objective subjective outcomes following placement snm sustained years treatment overactive bladder symptoms fecal incontinence minimal adverse events snm also promising results used treatment chronic pelvic pain interstitial cystitis painful bladder syndrome constipation neurogenic bladder although larger prospective trials long term evaluation needed truly establish snm effective intervention expanding indications snm well tolerated intervention refractory bladder bowel dysfunction recent long term longitudinal studies confirming efficacy safety gain insight snm mechanism action broader therapeutic indications anticipate snm become even widely utilized treatment complex pelvic floor disorders
normal flow depth important parameter design open channels analysis gradually varied flow open channels parabolic rectangular cross sections governing equations nonlinear terms normal depth thus solution implicit equations involves numerical methods current research explicit solutions channels obtained using asymptote matching technique parabolic channel maximum error proposed equation normal depth less near exact solution rectangular channels maximum error proposed equation normal depth less accurate efficiency asymptote matching technique considerably improved adding power law function two asymptotes rectangular channel new solution normal flow depth developed using improved asymptote matching technique proposed research maximum error full range solution less results showed improvement proposed solution substantial proposed full range solutions definite physical concept high accuracy easy calculation well suited manual calculations computer programming elsevier ltd rights reserved
paper presents comprehensive literature review drives adoption green building practices among construction stakeholders review based literature published peer reviewed journals systematic review literature authors able identify generic drivers stakeholders pursue total drivers identified reviewing selected empirical studies paper presents classification framework drivers framework comprises five main categories drivers external drivers corporate level drivers property level drivers project level drivers individual level drivers australia india china leading countries drivers research survey descriptive statistics seen widespread use examining drivers scope detailed investigations drivers developed countries much scope exists developing countries paper would enhance policy makers advocates understanding drivers help promote concept result checklist framework drivers paper also lays solid foundation researchers probe topic add knowledge base elsevier ltd rights reserved
multi craft asteroid survey significant data synchronization needs limited communication speeds drive exacting performance requirements tables used relational databases structure however domba distributed objects management based articulation deals data terms collections read write roadblocks data exist master slave architecture created utilizing gossip protocol facilitates expanding mission makes important discovery via launch another spacecraft open space box framework facilitates foregoing also providing virtual caching layer make sure continuously accessed data available memory upon closing data file recharging applied data
purpose clarify mechanism mediating effect hyperthyroidism cardiac function second month life rats methods male female sprague dawley rats assigned control triiodothyronine treated group treatment group started third day birth control rats eut received nacl body weight every second day days treated rats hyper received subcutaneous injections every second day days results hyperthyroidism decreased left ventricle volume male rats female euthyroid rats presented higher atrial nitric oxide synthase nos activity male rats hormonal treatment decreased enzyme activity sexes euthyroid male female rats similar atrial nos protein levels females higher caveolin cav protein levels treatment increased protein males female rats lower ventricular nos activity male rats hyperthyroidism increased nos activity sexes effect associated lower cav protein levels hyperthyroidism change cav protein levels male female rats conclusions results study demonstrating clinically relevant sex related differences pathophysiology hyperthyroid heart raised new questions regarding mechanisms responsible observed differences study suggests sex related intrinsic factors nitric oxide may modulate response hyperthyroidism leads cardiovascular dysfunction
patients increased thromboembolic risk tend form denser fibrin clots relatively resistant lysis sought investigate whether essential thrombocythemia associated altered fibrin clot properties plasma vivo plasma fibrin clot permeability coefficient turbidimetry clot lysis time clt measured consecutive patients platelet count control subjects matched age sex comorbidities fibrinolysis proteins inhibitors together platelet activation markers determined reduced prolonged clt observed differences remained significant adjustment fibrinogen platelet count associated slightly shorter lag phase higher maximum absorbency turbidimetric curve patients higher plasma selectin platelet factor higher selectin observed patients jak gene mutation higher higher plasminogen activator inhibitor pai unaltered thrombin activatable fibrinolysis inhibitor plasminogen antiplasmin activity found group inversely correlated fibrinogen reactive protein clt positively correlated pai patients display prothrombotic plasma fibrin clot phenotype including impaired fibrinolysis represents new prothrombotic mechanism disease
roadmap resource efficient europe aims waste managed resource thus materials ability reuse several types wastes alkali activated cement based binders aacbs merit special attention wastes like fly ash deserve special attention generated high amounts low reuse rate paper reports experimental results regarding influence mix design fly ash waste glass aacb mortars containing two different biopolymers carrageenan xanthan short term mechanical performance microstructure cost analysis also included results show mixture fly ash waste glass calcium hydroxide activated alkaline activator highest compressive strength results also show mortars minor biopolymer carrageenan content associated relevant increase compressive strength use carrageenan leads optimum compressive strength mixtures use xanthan shows beneficial effects compressive strength aacb mortars several mixtures xanthan even show reduction compressive strength
based detailed long term data wind regimes collected typical ventilation sites along railways gobi area xinjiang study systematically analyzes characteristics disastrous wind sand environment along railways combining gradient sand sampling data collected wind drift sand monitoring system site survey data wind direction speed rose diagrams revealed prevailing wind direction wind area along railways wind direction maximum frequency sandstorms occurred drift potential characteristic parameters rdp rdd direction variability rdp showed wind area along gobi railway featured long wind period strong power single wind direction special geological environment gobi determines wind drift sand features gravel large grain size unsaturation different wind drift sand deserts increasing wind velocity density wind drift sand increased steadily however certain critical value density surged study wind sand environment gobi significance railway safety critical value wind velocity corresponded abrupt increase wind drift sand density taken account planning process railway safety passage since lead decrease frontal visual distance associated decrease safety additionally specific features wind drift sand activities abruptness higher usual sand height considered process designing sand damage control engineering measures elsevier ltd rights reserved
increasing human animal proximity also increased risks zoonotic disease transmission study measured prevalence anti toxoplasma gondii anti leishmania spp anti leptospira spp igg antibodies dogs cats attended birth control project bcp determine environmental variables significantly associated infectious agents study population blood samples dogs cats collected jugular cephalic venipuncture serological analysis indirect immunofluorescence assays used detect anti gondii anti leishmania spp igg antibodies microscopic serum agglutination tests used detect anti leptospira spp antibodies data tabulation statistical analyses performed using epiinfo among canine sera samples positive gondii leishmania spp leptospira spp respectively higher gondii prevalence found dogs unknown breeding history fed raw undercooked meat receive polyvalent vaccine statistically significant association leishmaniosis leptospirosis variables evaluated epidemiological questionnaire among feline sera samples positive gondii highest prevalence rates observed felines hunted rodents consumed untreated water results confirmed ingestion raw undercooked meat drinking untreated water predation rodents important risk factors gondii infection low leishmania spp serodiagnostic prevalence observed frequent leptospira spp serovars copenhageni canicola butembo
genotype hepatitis virus hcv themost prevalent variants virus twomain subtypes hcv hcv associated differences epidemic features risk groups despite sharing similar features biological properties analyzed impact positive selection evolution variants using complete genome coding regions compared levels genetic variability distribution positively selected sites also compared distributions positively selected conserved sites considering different factors rna secondary structure presence different epitopes antibody secondary protein structure genome found positive selection purifying selection main evolutionary process acting subtypes found differences number positively selected sites subtypes several genes core hvr helicase nsa heterozygosity values positively selected sites rate non synonymous substitutions significantly higher subtypehcv logistic regression analyses revealed similar selective forces act genome level subtypes rna secondary structure cell epitopes associatedwith conserved sites cell epitopes associatedwith positive selection subtypes results indicate similar selective constraints acting along hcv hcv genomes despite differences distribution positively selected sites independent genes elsevier rights reserved
immunization programs around world undergo rapid change expansion supply chain logistics systems become strained making increasingly challenging national public health systems provide reliable safe efficient access vaccines governments immunization partners aware problem several years world health organization launched effective vaccine management evm process help countries identify shortcomings immunization supply chains develop plans systematic improvement evm improvement plans exist gavi eligible countries plus many middle upper income countries however implementation slow many cases fraught financial managerial structural political roadblocks recognizing significant change kind requires supportive policy environment strong leadership path began working uganda senegal landscape policy environment around immunization identify relevant policies administrative technical roles responsibilities issues may affecting supply chain immunization policy landscape assessments included desk review series structured depth interviews key international national local stakeholders findings highlighted number critical issues challenges countries may preventing supply chains functioning optimally challenges include need better coordination planning immunization programs supply chain managers need sufficient timely reliable financing aspects immunization programs need high level managers trained immunization supply chain management urgent need better timely data decision making overcoming challenges require involvement high level political actors including ministers health finance parliamentarians officials ability approve influence policy personnel structural changes ensure work plans backed adequate resources implementation hold program managers accountable achieving agreed indicators authors published elsevier ltd
entertainment computing central leisure activities many americans remarkable array choices available average person video computer games particular violent games especially popular even relatively young children popularity concern raised possible unintended consequences participation interactive violence desensitization violence cited one possible undesirable outcome video game violence little evidence relationship paper presents conceptual model supporting data begin examination possible relationships exposure violent video games desensitization examining correlates desensitization including empathy attitudes towards violence surveys children adolescents identified relationship greater exposure violent video games lower empathy stronger proviolence attitudes additional research needed substantiate understand causal implications results
organizational stressors particularly prevalent across sport performers experiences influence performance health well research conducted identify organizational stressors encountered sport performers little known experiences vary athlete athlete purpose study examine frequency intensity duration organizational stressors sport performers encounter vary function gender sport type performance level participants completed organizational stressor indicator sport performers osi arnold etal resultant data analyzed using multivariate analyses covariance findings show demographic differences apparent dimensions goals development logistics operations team culture coaching selection organizational stressors sport performers encounter specifically significant differences found males females team individual based performers performers competing national international regional university county club levels findings important implications theory research organizational stress development stress management interventions sport performers
aim study evaluate vitamin status non vegetarian sample adult urban population romania studied sample included non vegetarian subjects aged years use vitamin supplements vitamin fortified food serum vitamin assay performed using electrochemiluminescence immunoassay roche elecsys analyzer among subjects serum vitamin concentrations reference range employed method subjects found statistically significant correlations serum vitamin concentration age serum vitamin concentration hemoglobin level serum vitamin levels differ significantly student test women men subnormal serum levels vitamin observed investigated subjects associated irritable bowel syndrome long term therapy proton pomp inhibitors birth control pills present study identified large number subjects marginal depletion vitamin population aged years results suggest need screening vitamin status people age groups importance identification responsible causes high prevalence vitamin marginal status well fact monitoring vitamin status especially important subjects undergoing long term treatment certain drugs
einclusion main interest traditionally granting interaction ict accessibility interfaces due developments toward ami ambient intelligence information society technology interest accessibility integration multimedia interfaces matched user requirements preferences becoming interest general customers therefore point made paper concept einclusion already happened political level generalized include actions able guarantee well therefore becomes necessary collect knowledge activities necessary living comfortably enjoyably identify implement ict environment offering functionalities carry make available quantity quality intelligence necessary adapt environment different users contexts use
backgroundearly intervention practitioners provide individualised family centred services enhance quality life qol families children developmental delay family qol fqol could important outcome indictor measurement tool fqol mandarin chinese purpose study translate beach centre fqol scale bcfqol mandarin chinese examine psychometric properties scale families children methodstwo independent translations performed two bilingual professors whose mother tongue mandarin two back translations performed two bilingual professionals whose mother tongue english translated back translated questionnaires reviewed revise questionnaire five experts assessed accuracy equivalence cultural appropriateness scale parents children interviewed examine readability clarity cultural appropriateness july november recruited primary caregivers children receiving northern taiwan validate scale participants completed bcfqol well one item overall ratings fqol resultsitem analysis performed assess item confirmatory factor analysis supported following five factor structure original scale family interaction parenting emotional well physical material well disability related support scale exhibited excellent internal consistency reliability cronbach alpha test retest reliability week interval intra class correlation coefficient contrasted group validity supported significantly higher bcfqol scores top quartile overall fqol rating lowest quartile convergent validity supported significant correlation fqol item bcfqol conclusionsthis study showed mandarin chinese version bcfqol reliable valid taiwanese families children instrument could applied assess fqol families children receiving order evaluate family services supports
tennis type net confrontational sport requires high physical qualities high intensity combat tennis players engaged tennis certain years sport injuries common paper surveyed sport injuries students majoring tennis physical education school jiangxi normal university aim find causes induce sport injuries people reduce injuries future sport career results showed students injuries shoulder joints injuries waists knee joints elbow joints wrist joints ankle joints respectively students injured inadequate preparatory activities injured incorrect technical movements poor physical qualities inappropriate personal equipment bad venues respectively therefore avoid sport injuries students majoring tennis enough preparation movements improve technical movements physical qualities
article deals research russian university student attitudes toward drug use research conducted students smolensk universities took part sample consists three age groups students years older study results show students view people addiction negative context weak stupid unreliable unhappy also attitudes reflect support extreme punishment drug traffickers drug distribution blaming roma gypsies age student respondents significant factor affecting attitudes older students negative attitude people addiction inclined call harsh punishment study results provide usable information drug policy education prevention efforts russia
importance body sensor networks monitor patients prolonged period time increased advance home healthcare applications sensor nodes need operate low power consumption constraint limited memory capacity therefore wasteful digitize sensor signal constant sample rate given frequency contents signals vary time adaptive sampling established practical method reduce sample data volume paper low power analog system proposed adjusts converter clock rate perform peak picking algorithm second derivative input signal presented implementation require analog digital converter digital processor sample selection process criteria selecting suitable detection threshold discussed maximum sampling error limited circuit level implementation presented measured results exhibit significant reduction average sample frequency data rate respectively
power loss due mismatch effect among interconnected photovoltaic modules significantly reduced applying maximum power point tracking fine granularity level paper novel configuration proposed utilize sub module integrated converter submic effective solar energy harvesting gallium nitride gan field effect transistors fets used construct power circuits high conversion efficiency high power density detailed mathematical analysis presented provide insight architecture simulation carried demonstrate system behavior response real world atmospheric conditions hardware prototype consisting three submics developed utilizing gan fet power switches based industrial standard compact fit junction box commercial modules advantages terms conversion efficiency system cost dynamic performance experimentally proved comparison benchmark system
multilevel inverters nowadays widely used high power high voltage applications multilevel inverter synthesizes large number levels get desired output voltage levels lot merits improved output waveform smaller passive filter size lower electro magnetic interference reduced harmonics however multilevel inverters also disadvantages increased number components voltage balancing problem higher switching losses paper presents pid controlled cascaded bridge eleven level inverter based sinusoidal pulse width modulation control technique suitable improved power quality applications main objective reducing thd output chosen eleven level cascaded inverter set point tracking well steady state fast transient response proposed control point view simulation results discussed cascaded bridge eleven level inverter performs perfectly connection pid comparative analysis two different controllers revealed harmonic spectrum output voltage current waveforms obtained validate role controllers experimental results presented confirm simulation results
previous assessments childhood rhabdomyosarcoma indicated maternal birth characteristics may associated tumor development however much work remains identify novel confirm suspected risk factors objective evaluate associations maternal birth characteristics childhood rhabdomyosarcoma case control study included cases pair matched controls cases enrolled trial run intergroup rhabdomyosarcoma study group population based controls identified using random digit dialing individually matched cases race sex age families case control subjects participated telephone interview captured information maternal characteristics birth control use number prenatal visits anemia abnormal bleeding pregnancy birth characteristics birth weight preterm birth type delivery vaginal cesarean conditional logistic regression models used calculate odds ratio confidence interval exposure adjusted age race sex household income parental education two common histologic types rhabdomyosarcoma embryonal alveolar evaluated effect heterogeneity exposures characteristic associated childhood rhabdomyosarcoma statistically significant abnormal vaginal bleeding pregnancy birth control use anemia pregnancy preterm birth positively associated childhood rhabdomyosarcoma statistically significant low birth weight adjusted odds ratios aor high birth weight aor strongly associated alveolar rhabdomyosarcoma however factors display significant effect heterogeneity histologic types characteristics overall found little evidence maternal birth characteristics strongly associated childhood rhabdomyosarcoma
new mathematics often inspired new insights natural world describe ongoing possible future interactions among massive data sets collected neuroscience methods analysis mathematical models underlying still largely uncharted neural substrates generate data start recalling events occurred turbulence modelling substantial space time velocity field measurements numerical simulations allowed new perspective governing equations fluid mechanics analogous global mathematical model neural processes exists argue big data may enable validation least rejection models cellular brain area scales may illuminate connections among models give examples models survey relatively new experimental technologies including optogenetics functional imaging report neural activity live animals performing complex tasks search analytical techniques data already yielding new mathematics believe multi scale nature may help relate well established models hodgkin huxley equations single neurons abstract models neural circuits brain areas larger networks within brain brief envisage closer liaison marriage neuroscience mathematics
linear regression models popular choice relationships water quality parameters bands band ratios remote sensing data however research regards phenomena mixed pixels specular reflection water fluidity challenges establish robust regression infidel based data measurements situ remote sensing data study presents enumeration based algorithm called matching pixel pixel mpp tests performance empirical model water quality mapping four small reservoirs cover mere several hundred thousand kinmen taiwan selected study sites multispectral sensors carried unmanned aerial vehicle uav adopted acquire remote sensing data regarding water quality parameters including chlorophyll chl secchi disk depth sdd turbidity reservoirs experimental results indicate mpp reduce influence specular reflection regression model establishment specular reflection hamper correction thematic map production due water fluidity sampling situ followed uav imaging soon possible excluding turbidity obtained estimation accuracy satisfy national standard elsevier rights reserved
research violent video games suggests play leads aggressive behavior longitudinal study online violent video game control group tested changes aggressive cognitions behaviors findings support assertion violent game cause substantial increases real world aggression findings presented discussed along implications research policy
upper lower thoracolumbar spine associated different biomechanical outcomes concept applies osteoporotic fracture risk well documented case control study patients seen osteoporosis clinic vertebral fractures identified lateral radiographs using genant semi quantitative assessment method association bone mineral density bmd scores vertebral fracture location assessed additional analysis association history traumatic injury possible predictor variables also explored median age patients iqr patients female history trauma reported patients vertebral fracture lower thoracolumbar spine associated significantly higher femoral neck lumbar trochanteric intertrochanteric total hip bmd scores odds femoral neck total hip score less also lower among patients vertebral fractures lower thoracolumbar spine fracture upper thoracolumbar spine decreased odds history traumatic injury non vertebral fracture increased odds injury vertebral fractures lower thoracolumbar spine associated higher bmd scores studied understand possible correlations patients future fracture risk
social communication impairments core deficit autism spectrum disorder social communication deficit also early indicator autism spectrum disorder factor long term outcomes thus symptom domain represents critical treatment target identifying reliable valid outcome measures social communication across range treatment approaches essential autism speaks engaged panel experts evaluate readiness available measures social communication use outcome measures clinical trials panel held monthly conference calls two face face meetings months key criteria used evaluate measures included relevance clinical target coverage symptom domain psychometric properties validity reliability well evidence sensitivity change measures evaluated measures considered appropriate use limitations report discusses relative strengths weaknesses existing social communication measures use clinical trials identifies specific areas need development
recognition physical child abuse imperative ensuring children safety screening tools may increase identification physical abuse however extent use unknown study assessed use sts physical abuse children hospitals determined attitudes regarding sts web based survey sent child abuse program contacts children hospitals survey assessed institutional use physical abuse characteristics used respondents asked identify benefits liabilities sts used barriers use seventy two respondents completed survey child abuse pediatricians nine respondents reported using physical abuse sts varied length population administration outcomes positive screen respondents using felt increased detection abuse barriers noted included lack time development provider completion respondents endorsed use physical abuse believed increased detection abuse future research focus development brief uniform physical abuse may increase detection risk children
hrdbms novel distributed relational database uses hybrid model combining best traditional distributed relational databases big data analytics platforms hive allows hrdbms leverage years worth research regarding query optimization also taking advantage scalability big data platforms system uses execution framework tailored relational processing thus addressing performance challenges running sql top platforms mapreduce spark include excessive materialization intermediate results lack global cost based optimization unnecessary sorting lack index support statistics support dml acid excessive communication caused rigid communication patterns enforced platforms
normal sleep wake conditions noradrenaline secretions supine subjects exhibit weak circadian variation peak occurs around noon sleep span characterized reduced secretion investigators reported circadian rhythm completely obliterated sleep deprivation laboratory plasma assayed every hour nine healthy men years age men deprived sleep required eat walk around every hour prevent sleep however subjects remained supine min blood samples collected eliminate effect activity persistence slight decrease night concentration several subjects despite sleep deprivation suggests secretion may influenced biological clock whose activity becomes visible influence posture removed
purpose purpose paper investigate impact control strategy selection power performance wave energy converters different ratings power take pto system design methodology approach case point absorber equipped electric pto considered effect control techniques electrical generator design analyzed theoretical standpoint verified integrated hydrodynamic electric simulations findings proved control parameters maximize power extraction waves derived based power torque constraints imposed electrical machine originality value optimized integrated approach control strategy selection generator design point absorbers presented maximizes electric power generation sea waves real conditions represents good trade pto technical economic standpoint
paper discusses technology smart grid implementation distributed generation used improve reliability existing power supply zawea refinery critical loads zawea refinery electric network experienced active power fluctuations connected national grid fluctuations causes disturbances electrical network operation hours order mitigate fluctuations smart grid technologies proposed improve performance existing power system
experimental study focuses unsteady pressure characteristics two box bridge decks models vertical plates gratings several gap length configurations investigated compared single box cross sections results demonstrate respect unsteady pressure characteristics upstream box barely affected slot behaves similarly single box model contrast unsteady pressure characteristics dowstream box defined mainly characteristics slot geometry cross section upstream box geometric configuration plays minor role definition unsteady pressure characteristics dowstream box equivalent theodorsen function used calculation aerodynamic derivatives two box girders proposed using function demonstrated aerodynamic derivative aerodynamically dependent gap length findings suggest results single box investigations extended two box cross sections elsevier ltd rights reserved
objective identify empirical evidence diagnostic delay spondyloarthritis spa determine whether sex related differences persist conduct analysis perspective possible causes including influence quality research group inflammatory rheumatic diseases methods systematic review done delay diagnosis spa medline embase sources study quality determined line strengthening reporting observational studies epidemiology strobe statement metaanalysis papers reporting sex disaggregated data performed evaluate sex related differences diagnostic delay global effect diagnostic delay sex calculated using means difference fixed effects model results review included patients women papers significant differences sexes detected symptoms disease onset evolution however mean delay diagnosis spa showed sex related differences years women men papers high quality metaanalysis included participants women mean global effect years indicating men diagnosed year months women conclusion delay diagnosis spa persists longer women men significant sex related differences symptoms could explain sex related differences diagnostic delay methodological possible publication bias could result sex biased medical practice
context data incidence injury middle school sports limited objective describe overall practice game injury rate patterns middle school sports design descriptive epidemiology study setting injury data collected year period single school patients participants boy girl athletes participating middle school sports respectively main outcome measure injury status athlete exposures aes collected certified athletic trainers incidence rates per aes injuries aes calculated overall incidence practices games injury location injury type injury severity time lost participation rate ratios rrs confidence intervals cis used compare injury rates sex matched sports results football highest injury rate injuries aes time loss injuries aes matched middle school sports girls exhibited higher injury rate injuries aes time loss injuries aes boys injuries aes time loss injuries aes girls higher injury rate practices aes games aes sports gymnastics higher game injury rate girls practice game injury rates nearly identical boys sports football boys wrestling reported higher game injury rates tendinitis injuries accounted middle school injuries conclusions risk sport related injury middle school level greater practices games greater girls boys sex matched sports conditioning programs may needed address high rate tendinitis injuries
background ideal energy dosing remains unclear second generation cryoballoon pulmonary vein isolation pvi aimed investigate effect individualized dosing strategy based time pvi tti objective purpose study prospectively investigate safety efficacy individualized pvi using second generation guided real time pulmonary vein recordings methods two groups prospectively randomized ice group tti seconds bonus freeze control group acute pvi followed empiric bonus freeze freeze duration set seconds primary end point single procedure sinus rhythm months blanking period months secondary end points included procedural data complications biomarker release results total patients paroxysmal atrial fibrillation randomized primary end point different procedure fluoroscopy times significantly shorter ice group minutes minutes seconds independent predictor recurrent atrial tachyarrhythmia conclusion individualized pvi strategy allows faster atrial fibrillation ablation without affecting favorable clinical outcome short tti appears predict freedom recurrent atrial tachyarrhythmia
current studies memory complex emotional events suggest arousal enhances long term memory central peripheral information study aims use cahill mcgaugh slideshow procedure new recognition test investigate relationship emotional arousal true false memories moderated information type central peripheral one week watched either emotional arousal neutral version procedure results revealed arousal version story leads better memory retrieval true peripheral information false central information possible implications results eye witness study discussed
static dynamic characteristics edm machine main machining unit directly influence machining accuracy stability particular type edm machine three dimensional model built solidworks finite element method employed ansys workbench analyze static dynamic characteristics machine results show stiffness ram vertical guide axis directions weak side machine analytical method proved effective optimization machine design
background objective study demonstrate feasibility associations short term outcomes medical nutrition therapy mnt intervention patients systemic scleroderma ssc materials methods eighteen patients ssc gastrointestinal involvement unintentional weight loss consented recruited week mnt intervention addition usual medical management mnt emphasized increased calorie protein intake modified textures lifestyle modifications symptoms anthropometrics diet hour recall body composition dual energy ray absorptiometry assessed pre postintervention sarcopenia defined appendicular lean height alh women men descriptive parametric nonparametric statistics conducted results participants predominantly white female malnourished years age body mass index significant decreases nutrition symptom scores improvements alh respectively occurred pre postintervention respectively sarcopenia observed participants baseline follow caloric intake kcal macronutrient distribution fat protein carbohydrate change significantly pre postintervention respectively conclusions individually tailored mnt improve symptom burden potentially alh patients ssc involving tract study underscores clinical potential multidisciplinary patient management need larger nutrition intervention trials longer duration patients
today disposable diapers high performance well tested products designed keep skin dry healthy primarily made biologically inert polymers commonly used fabrics materials contact skin foods cosmetics still product safety ingredients everyday products source anxiety new parents article provides facts behind commonly asked questions consumers diaper ingredients safety including myths facts related chlorine latex dyes chemical additives
food intake reduced estrogenic hormones levels vary throughout life fluctuate throughout ovarian cycle females however estrogens also shown increase reward derived drugs abuse motivational properties drugs progression addiction potentiated estrogens whether reward derived food specifically motivational properties food altered estrogens remains unknown investigated effect estrous cycle food reward behavior show estrous cycle dictated variability food motivation measured progressive ratio operant conditioning female rats reward behavior lowest days associated high estrogen signaling therefore also examined actions subcutaneously administered estradiol food reward found thatp estradiol reduced food reward behavior ventral tegmental area vta crucial node neurocircuitry underlying motivated behavior estrogen receptors expressed nucleus thus examined whether effects estrogens reward exerted directly level vta intra vta microinjection estradiol led significant reduction food motivated behavior interestingly effect accompanied reduction chow intake body weight alter locomotor activity importantly removal ovaries produced potent lasting elevation food reward food seeking behavior suggesting ovarian sex steroids critical maintenance normal mod reward behavior data reveal novel role estrogens control food reward behavior elsevier ltd rights reserved
background children enrolled migrant seasonal head start mshs programs high risks health problems although non family child care providers play important roles children health status role models educators program deliverers information mediators little known nutritional health attitudes behaviors weight status therefore investigated nutritional health attitudes behaviors associations overweight obesity among child care providers michigan mshs centers methods total child care providers aged years working michigan mshs centers included cross sectional study conducted online survey questionnaire used collect data nutritional health attitudes behaviors child care providers weight status categorized normal weight bmi overweight bmi based child care providers self reported height weight factor analysis performed investigate patterns nutritional health attitudes behaviors multivariate logistic regression conducted estimate odds ratios ors confidence intervals cis overweight obesity across tertiles pattern scores taking lowest tertile group reference group adjustment potential confounding variables results three patterns nutritional health attitudes behaviors identified pattern weight loss practices weight dissatisfaction pattern healthy eating behaviors pattern better knowledge nutrition health pattern scores positively associated overweight obesity tertile tertile tertile tertile within pattern overweight obesity individuals highest scores compared lowest scores however pattern associated risk overweight obesity conclusions findings support nutrition education health interventions targeting mshs child care providers urgently necessary efforts might efficient effective approach improving nutritional health status young children enrolled mshs programs
paper experimental designs considered classic extreme value distribution models careful review literature provides information matrices order study experimental designs regression models design implications discussed situations involving extreme values include constant variance constant coefficient variation model plus application context strength materials relative efficiencies calculated respect optimality used compare designs given example
background animal models human behavioural deficits involve conducting experiments animals hope gaining new knowledge applied humans paper aims address risks biases fallacies associated drawing conclusions conducting experiments animals focus animal models mental illness conclusions researchers using animal models susceptible fallacy known false analogy inferences based assumptions similarities animals humans potentially lead incorrect conclusion also risk false positive results evaluating validity putative animal model particularly experiment conducted double blind argued animal model experiments reconstructions human experiments replications per animals follow instructions leads experimental setup altered accommodate animals typically involves smaller sample size human experiment researchers animal models human behaviour increase focus mechanistic validity order ensure underlying causal mechanisms driving behaviour relying face validity makes model susceptible logical fallacies higher risk type errors discuss measures reduce bias risk making logical fallacies animal research provide guideline researchers follow increase rigour experiments
sustainability become important initiative discussed undertaken private buildings also public buildings dealing residential office commercial well hospital sustainable building practice designing constructing operating maintaining removing buildings ways conserve natural resources reduce pollution rating systems provide effective framework assessing building environmental performance measure building sustainability applying set criteria organized different categories good green building rating system gbrs cover key indicators reflecting building characteristics keep performance balance paper proposed knowledge based expert system tool assess performance level green building based assessment factors green building rating systems analytic hierarchy process ahp fuzzy logic adopted order develop knowledge based expert system data research collected experts field via pair wise likert based questionnaires using ahp important parameters rating systems according weights selected incorporated fuzzy inferences system fis fuzzy logic model fuzzy rules knowledge discovered collected data fis assess performance level green buildings environmental social economical perspectives denoted outcome research accordingly performance assessment tool analyzes effect factors developing sustainable building elsevier rights reserved
due ability model large deformations ease dealing boundary conditions lagrangian framework material point method getting popularity geotechnical engineering applications paper material point tentatively applied model problems hydrodynamics introduction field dam break flows different initial aspect ratios simulated material point method extensively verified shallow water equations model order test accuracy stability material point method simulations dam break flows carried results good agreement validated numerical methods experimental data comparisons simulations material point method shallow water equations model critical aspect ratio value applicability shallow water equations found material point method shows potential tackle hydrodynamics related problems authors published elsevier ltd
purpose purpose paper show possibility new functions integrated parts created powder bed based printing technology one big advantage additive manufacturing technologies possibility create function integrated parts manufacturing process applies mechanical functions like movable elements thermodynamic functions like contour near cooling channels part well electrical functions like conductive lines electrical components design methodology approach powder bed based printer utilized process polymethyl methacrylate pmma base material enable new functionalities automated exhausting mechanism implemented test system created cavities filled new components rather new materials findings three different approaches shown paper first one integration screw nuts enhance bolted joints compared threads directly created part average tensile strength could raised second approach integration different reinforcement elements like carbon metallic fibers reinforcement tensile strength approximately per cent could reached last approach shows method integrate conductive material well electrical components part create simple electrical circuits originality value paper demonstrates extend additive powder bed based technology powder exhausting mechanism possibilities technology illustrated three examples integrating mechanical well electrical functions part
many atypical antipsychotic drugs currently prescribed treatment schizophrenia limited brain penetration due efflux activity atp binding cassette abc transporters blood brain barrier bbb including pglycoprotein abcg herein describe design synthesis first class homodimeric prodrug dual inhibitors abcg inhibitors based structure atypical antipsychotic drug paliperidone pal transport substrate transporters synthesized characterized small library homodimeric bivalent pal inhibitors contain variety tethers joining two monomers via ester linkages majority compounds low micromolar sub micromolar inhibitors abcg cells overexpressing transporters immortalized human hcmec cells derived bbb potent dual inhibitor also contained internal disulfide bond tether pal allowed rapid reversion monomer presence reducing agents plasma esterases increase stability esterases engineered pal contain two hindering methyl groups alpha carbonyl ester moiety within tether resulting diner ssme also potent dual inhibitor remained susceptible reducing conditions resistant breakdown human plasma importantly pal ssme accumulated subsequently reverted therapeutic pal monomer reducing environment bbb cells thus molecules serve two purposes acting bath inhibitors abcg bbb prodrugs effectively delivering therapies brain would otherwise precluded
college time immense stress mindfulness meditation shown effective stress management technique significant limitation mindfulness literature however reliance inactive control groups compared mindfulness intervention ecologically valid active control interacting dog group study break treatment control participants randomly assigned groups treatment groups completing weekly sessions duration end session mindfulness group exhibited significantly lower state anxiety compared groups dog group also significantly less anxious control group addition dog mindfulness groups exhibited significantly less dysphoric affect control group participants came posttreatment assessment given cognitive stressor challenge electrocardiogram data collected cognitive challenge allowing assess heart rate variability hrv measure body ability modulate physiological stress response participants mindfulness group exhibited significantly higher hrv cognitive challenge groups signifying adaptive response stress individuals dog group meanwhile different control participants preliminary findings suggest brief mindfulness training help college students manage stress response ubiquitous academic cognitive challenges college life
amyotrophic lateral sclerosis als associated executive dysfunction behavioural impairment recent studies suggested social cognitive deficits might also prominent feature als current meta analysis aimed summarize available evidence deficits social cognition including theory mind tom emotion recognition als meta analysis studies facial emotion recognition tom performances patients als healthy controls compared als associated significant impairments medium effect sizes tom facial emotion recognition among individual emotions recognition disgust surprise particularly impaired deficits perspective taking aspects tom tom pronounced comparison decoding aspects tom tom decoding severity social cognitive impairment similar level executive dysfunction significant relationship social cognition executive dysfunction deficits social cognition part cognitive phenotype als elsevier ltd rights reserved
antisocial personality disorder aspd characterized incapacity individual adapt social norms social norms extremely important govern many aspects behavior adolescence adulthood patients aspd typically irritability problems aggressive feelings toward people aggressive feelings toward people expressed context threat intimidation aspd less common clinical settings comparing total population prevalence familial aggregation aspd registered variance explained genetic influences studies aspd molecular genetics applying hypothesis association candidate genes focusing genes associated neurotransmission pathways greatly relevant monoamine oxidase gene mao genes promote specific behavior individuals must selected process natural selection aggressive behaviors types behavior evolutionary origin similar fact codified genes later transmitted descendants
depression complex disorder influenced variety biological environmental factors due significant heterogeneity remarkable differences patients respond treatment primary objective psychiatric research identify biological markers could used better predict enhance responses antidepressant treatments diet impacts various aspects health including depression fatty acid composition western diet high ratio polyunsaturated fatty acids associated increased incidence depression brain rich lipids dietary fatty acids act within specific brain regions regulate processes impact emotional behavior manuscript reviews existing evidence demonstrating brain region specific fatty acid profiles posits specific fatty acids may serve predictive biomarkers response antidepressants furthermore increasing blood levels certain fats via dietary intervention may serve adjunct improve efficacy antidepressants notably existing research regarding fats depression related brain regions focused compared monounsaturated saturated fats review article help guide future work investigating relationships fatty acids brain regions antidepressant efficacy
earthquake induced landslides serious natural hazards shocked tremendous casualties great economic losses many mountainous areas around world however predicting preventing earthquake induced landslides difficult due complicated relationship seismic dynamics coseismic landsliding comprehensive understanding earthquake induced landslides perspective seismic dynamic mechanism remains inadequate present study employs elastoplastic spectral element method incorporating parallel computing represents realistic three dimensional slope model via semi structured hexahedral mesh investigate dynamic failure characteristics earthquake induced landslides dynamic behaviours slopes simulated using continuumbased approach mohr coulomb yield criterion displacement fields calculated using shear strength reduction technique pseudo static seismic loading performed assess slope stability quantitatively complex topography taken consideration xinzhong landslide occurred beichuan country one destructively collapsing landslides triggered wenchuan earthquake therefore selected case study discussion three dimensional visualization calculated results quantitatively demonstrated three dimensional numerical model well reproduced coseismic landsliding response essential dynamic failure pattern could purely captured geographic information systems gis remote sensing technologies calculated using simply two dimensional numerical model numerical results also showed tensile shear fractures significant influences nature failed surface development addition presence seismic loading slope could cause obvious disturbances slope stability comparative analysis indicated shear surface earthquake induced slope shorter tension crack surface deeper normal gravity condition moreover landslide mainly occurred transition upper lower part slope indicating slope topography one crucial factors resulting slope failure although model constructed without presence pre existing failure surface comparative analysis addressed failure surface obtained numerical simulation close agreement post failure investigations results could provide insight better understanding relationship landslide seismic dynamic mechanism study practical significance effective prevention mitigation earthquake induced landslide hazards
objectiveestablish whether inflammatory biomarkersserum amyloid saa reactive protein crp interleukin tumor necrosis factor tnf related key symptoms depression including anxiety fatigue cross sectional patient setting identify biomarkers reflect psychiatric symptomatology naturalistic real life population methodswe measured saa crp tnf plasma samples adult psychiatric patients multiplex high sensitivity electrochemiluminescent assays psychiatric symptoms evaluated using hamilton depression rating scale hamd patient health questionnaire phq center epidemiological studies depression scale ces resultsplasma saa robustly associated depressive symptoms across diagnostic boundaries cohort patients elevated saa significantly associated higher total scores hamd scale correlated multiple scale items rated symptoms fatigue depressed mood anxiety related items conclusionssaa might constitute cross diagnostic marker indicative depressed mood fatigue naturalistic patient setting saa activates toll like receptors present macrophages glial cells association depression severity could also implicate inflammatory mediator pathogenesis mood disorders
paper detailed mathematical physical model presented order calculate impedance tooth proposed model based amp balanced wien bridge oscillator voltage divider amplitude signal phase shift calculate resistance capacitance tooth
tabletop gameplay players monitor gaze throughout providing form implicit nonverbal communication player infer intention potential strategies estimating gaze another especially located gameplay early work progress paper details exploratory study design explores effects gaze awareness gameplay particular gaze one players augmented game revealed others believe players may well change strategies gaze becomes common knowledge also used form deception explore effects game two settings screen based digital version players separate rooms located tabletop board game version augmented projector work evaluates effects gaze awareness settings providing new insights towards emerging research eyeplay
social groups aid human beings several ways ranging fulfillment complex social personal needs promotion survival despite importance group affiliation humans remains considerable variation group preferences across development current study children adolescents completed explicit evaluation task ingroup group members functional neuroimaging found participants displayed age related increases bilateral amygdala fusiformgyrus orbitofrontal cortex ofc activation viewing group relative group faces moreover found indirect effect age group favoritism via brain activation amygdala fusiform ofc finally age youth showed greater functional coupling amygdala several neural regions viewing group relative group peers suggesting role amygdala directing attention motivationally relevant cues findings suggest motivational significance processing group membership undergoes important changes across development
particulate matter exposure linked adverse health effects numerous studies therefore governments heavily incentivising market switch electric passenger cars order reduce air pollution however literature review suggests electric vehicles may reduce levels much expected relatively high weight analysing existing literature non exhaust emissions different vehicle categories review found positive relationship weight non exhaust emission factors addition electric vehicles evs found heavier equivalent internal combustion engine vehicles icevs result total emissions evs found equal modern icevs emissions lower evs compared modern icevs therefore could concluded increased popularity electric vehicles likely great effect levels non exhaust emissions already account emissions traffic proportions continue increase exhaust standards improve average vehicle weight increases future policy consequently focus setting standards non exhaust emissions encouraging weight reduction vehicles significantly reduce emissions traffic elsevier ltd rights reserved
data literature regarding care pathway pancreatic cancer patients limited objective repere survey identify describe initial stages care pathway pancreatic patients metastatic phase may october oncologists gastroenterologists specialized digestive oncology gesdo general practitioners completed electronic questionnaire pathway patients recently diagnosed metastatic pancreatic adenocarcinoma patients completed questionnaire given specialized physician gesdo weight loss fatigue anorexia main signs symptoms motivated patients seek medical advice patients general practitioner first medicine doctor consulted according respondents patient general practitioner specialist median delay onset first symptoms final diagnosis pancreatic cancer days time lapse tended decrease associated jaundice days average standard deviation patient concerns triggered first symptoms days average standard deviation contrary time lapse longer days average standard deviation general practitioner prescribed symptomatic treatment conclusion diagnostic management patients metastatic pancreatic cancer accelerated efforts raise practitioners awareness
generalized anxiety disorder gad common mental disorder several treatment options including pregabalin patients respond treatment quickly determining patients respond important treatment goal patient level data pooled nine phase iii randomized double blind short term placebo controlled trials pregabalin treatment gad efficacy outcomes included change baseline hamilton anxiety scale ham total score psychic somatic subscales predictive modelling assessed baseline characteristics early clinical responses determine predictive clinical improvement endpoint total patients included analysis pregabalin placebo pregabalin significantly improved ham total score compared placebo endpoint treatment difference confidence interval pregabalin significantly improved ham psychic somatic scores compared placebo improvement ham total psychic somatic score predictive endpoint greater equal improvement ham total score pregabalin effective treatment option patients gad patients early response pregabalin likely respond significantly endpoint copyright wolters kluwer health inc rights reserved
data digitisation analogue signals detectors digital data essential process ion beam analysis iba low cost easy availability development environments low learning threshold makes system chip soc microcontrollers attractive task combine one die analogue digital inputs outputs serial usb interfaces opens simple implementation tailor made interfaces specific iba measurement systems investigated design performance limitations based development three different digitisation interfaces iba two channel nuclear instrumentation module nim adc event mode interface emi high resolution magnetic rbs spectrometer simple headless multi channel analyser mca combined dual channel headless mca emi shown soc based interfaces digitisation analogue spectroscopy pulses iba systems implemented material costs less epsilon performance soc devices many iba applications close achieved state art instruments simple pulse spectroscopy interface circuit software included auxiliary archive elsevier rights reserved
objective behcet disease systemic inflammatory disorder polarised immune systems allergic diseases polarised immune system aim present study investigate prevalence allergic diseases patients methods study involved large scale interview survey japanese patients institutes ophthalmology patients males females recruited study analysed history allergic diseases atopic dermatitis allergic rhinitis bronchial asthma drug food allergies results oral aphthous ulcers ocular lesions skin lesions genital ulcers arthritis neurological lesions intestinal lesions deep vein thrombosis epididymitis reported patients respectively also reported patients histories allergic diseases cases cases cases cases percentage significantly lower survey japan ministry health labour welfare conducted healthy population odds ratio confidence interval frequencies posterior panuveitis relatively severe ocular findings visual prognosis affected history allergic diseases conclusion patients fewer complications allergic diseases entire population japan
background psychosocial factors linked loss follow ltfu clinical outcomes among people living hiv plh however little known effect psychosocial support ltfu among plh treatment care purpose study explore effect namweza yes together friends psychosocial support intervention clinical outcomes ltfu among plh namweza based novel program using appreciative inquiry positive psychology approaches empower promote positive attitudes foster hope methods plh participating namweza intervention hiv care clinics dar salaam tanzania compared non exposed plh obtained facilities routinely collect clinical information followed longitudinally months baseline sociodemographic clinical measures cell count hemoglobin hgb weight ltfu measures collected chi square fisher exact tests tests used compare frequencies categorical variables means continuous variables intervention comparison groups identify variables significantly different across two groups random effects models performed examine bivariate associations intervention status clinical outcomes results end months follow mean count hgb levels increased significantly intervention comparison groups respectively weight increased significantly intervention group cumulative ltfu three times higher comparison compared intervention group low count extremes weight low hgb younger age male gender significantly associated ltfu among unexposed group art duration months protective ltfu intervened conclusion among plh art exposed exposed namweza intervention clinical care outcomes improved time ltfu much higher comparison group factors commonly known predict ltfu apparent comparison group namweza could promising peer facilitated model reduce ltfu among plh care integrated art services however research needed evaluate longer term effects
result relief image surface pattern shapes often complicated rules geometry detailed traditional computer graphics methods difficult achieve realistic embossed reproduction effect practical processing effect present new theoretical achievements field china paper designed simple method get relief effect fast color images based cellular neural networks cnn embossment effect processing method simulation experiment method proved convenient operation implementation application hail cloud layer image pre processing achieved good results
lycoriella ingenua dufour diptera sciaridae major pest species commercial mushroom agaricus bisporus production throughout world grower demand alternative control measures following recent withdrawal number chemical control options led label extension use fungal biopesticide botanigard control mushroom flies semi field trials conducted evaluate efficacy botanigard two alternative formulations beauveria bassiana strain gha active ingredient botanigard control ingenua effect crop yield incorporated spawning data collected two replicated trials demonstrated incorporation bassiana detrimental mushroom yield also ineffective controlling development ingenua larvae artificially infested compost subsequent laboratory bioassays demonstrated ingenua eggs larvae susceptible infection bassiana strain gha whereas pupae somewhat susceptible mortality bioassays conducted adult ingenua using exposure surface sprayed botanigard resulted mortality within days mean survival time days significantly different control population elsevier inc rights reserved
study sought identify influential factors stereotypes social distance prejudice toward racial ethnic minorities united states used data american general social survey gss analysed data individuals caucasians african americans others males females data analysed using spss statistics program order test differences racial prejudice demographic characteristics stereotyping social distancing utilised variance regression analyses procedures results suggest stereotypes social distance effects prejudice toward african americans vary according ethnicity gender age education income specifically older less educated white males prejudiced toward african americans individuals sociodemographic groupings direct relationship holding stereotypical views social distance showed higher levels stereotyping maintained greater social distance african americans showed greater implicit prejudice toward racism toward african americans remains major social concern usa largely influenced sociodemographic factors
taiwan launched program dubbed four emerging intellectual industries lists intelligent green buildings aim promoting intelligent green building stimulate architecture technology industry combined information communication technology ict concept green building provide safe healthy living environment also aim reduce carbon emissions save energy study investigates intelligent green building policies promotion progress taiwan probes cases key success factors derived analyzing summarizing intelligent green building experiences taiwan done secondary data analyses establishing clear norms standards intelligent green building design improvement first carrying policies public sector order provide field trial safeguarded market opportunities industries implementing rating based assessments order raise quality design mandatory incentive policies introduced depending local specialties conditions respectively planning incentives relevant interested parties industrial chain strengthening marketing efforts proactively promoting policies elsevier ltd rights reserved
closed loop systems electro hydraulic servo system including position acceleration force closed loop systems closed loop transfer functions based parameter model adaptive identified using recursive extended least squares algorithm position force closed loop tracking controllers designed proportional integral derivative controller tuned position force step signals acceleration closed loop tracking controller designed three variable controller three states include position velocity acceleration experimental results estimated position acceleration force closed loop transfer functions performed actual electro hydraulic servo system using xpc rapid prototyping technology clearly demonstrate benefit adaptive identification method
aiming mispunchproblem emulsion impact hammer cone type piston buffering structure adopted minimize impact impact process simulation model differential connection piston built usingamesim software influences different buffer length conical angles buffer clearance terminal velocity pressure analyzed according model optimum parameters half cone angle degrees length well clearance determined collision progress piston guide sleeve ssimulated dyna software shows maximum stress mpa locates edge liquid inlet hole guide sleeve maximum stress interface less mpa area lower theyield strength materials guide sleeve shock resistance however found rebounding phenomenon buffering process mispunch attentively prevented
background major depressive disorder mdd high personal socio economic burden patients fail achieve remission first antidepressant biological mechanisms behind antidepressant response partially known genetic factors play relevant role combined predictor across genetic variants may useful investigate complex trait methods polygenic risk scores prs used estimate multi allelic contribution antidepressant efficacy overlap mdd schizophrenia constructed prs tested whether predicted symptom improvement remission gendep study star study vice versa including whole sample patients treated escitalopram citalopram using summary statistics psychiatric genomics consortium mdd schizophrenia tested whether prs disorders predicted symptom improvement gendep star five studies results significant prediction antidepressant efficacy obtained prs gendep star analysis might underpowered evidence overlap genetics antidepressant response either mdd schizophrenia either individual studies meta analysis stratifying antidepressant alter results discussion identified significant predictive effect using prs pharmacogenetic studies genetic liability mod schizophrenia predict response antidepressants suggesting differences genetic component depression treatment response larger homogeneous studies necessary obtain polygenic predictor antidepressant response elsevier inc rights reserved
paper presents comparative analysis different stakeholders view leed certified building projects indoor environmetal quality ieq parameters perspective key performance indicators kpis occupant satisfaction project cost performance within context comprehensive literature review respresenting studies indoor environmental quality relationship occupant satisfaction terms thermal comfort daylighting acoustic control project cost premium investment performances etc conducted analytical hierarchy process ahp model constructed indicating effects ieq parameters occupant satisfaction project cost performance ratings effects parameters collected brainstorming workshop participation different stakelholders sustainable design researchers practitioners leed consultants data analysed conducting ahp analysis multi crtieria decision method analysis results revelaed thermal comfort interior lighting daylight acoustic performance environmental tobacco smoke control parameters highest rankings among occupant satisfaction whereas low emitting materials daylight thermal comfort acoustic performance ones project cost performance
paper shall first describe low energy nuclear transmutation theory lent apply describe smart material piezoelectric rock crushed induce nuclear reactions production neutrons observed experimental program set perugia realizing lent also briefly noted
cesium lead halide perovskite quantum dots pqds emerged promising new platform lighting applications however date light emitting diodes led based materials exhibit limited efficiencies one hypothesized limiting factor fast nonradiative multiexciton auger recombination using ultrafast spectroscopic techniques investigate multicarrier interaction recombination mechanisms cesium lead halide pqds mapping dependence biexciton auger lifetime biexciton binding energy nanomaterial size composition find unusually strong coulomb interactions among multiexcitons pqds results weakly emissive biexcitons trions accounts low light emission efficiencies observe strong confinement biexciton lifetime depends linearly pqd volume dependence becomes sublinear weak confinement regime pqd size increases beyond bohr radius demonstrate auger recombination faster pqds compared cdse nanoparticles volume suggesting stronger coulombic interaction pqds confirm demonstrating increased biexciton binding energy reaches maximum mev fully three times larger cdse quantum dots biexciton shift lead low threshold optical gain materials findings also suggest materials engineering reduce coulombic interaction cesium lead halide pqds could improve prospects high efficiency optoelectronic devices core shell structures particular type nanostructures known reduce bandedge coulomb interaction cdse cds could beneficially applied pqds goal increasing potential lighting applications
backgroundserious games may useful tools asthma education objectives systematic review identify available articles serious games designed educate patients general public asthma assess impact patient knowledge behavior clinical outcomes related asthma methodspubmed embase cochrane library psychinfo web science systematically searched january december studies investigating serious games asthma education two investigators independently assessed studies inclusion criteria rated included indicators quality investigators extracted data serious games content learning objectives outcomes following kirkpatrick classification resultsa total articles found relevant describing total serious games serious games directed toward children eight games children asthma two school based intervention average medical education research study quality instrument score high serious games associated high rates satisfaction improvement children knowledge seven studies evaluated impact serious games clinical outcomes found significant difference relative control groups conclusionsalthough serious games designed asthma education evolved advances technology results evaluation remained similar across studies clear improvements knowledge little change behaviors clinical outcomes
intramembrane proteases comprise number different membrane proteins different types catalytic sites common denominator cleavage within plane membrane usually results peptide bond scission within transmembrane helices substrates despite recent progress determination high resolution structures illustrated gamma secretase complex substrate still unknown enzymes function distinguish substrates non substrates principle substrate non substrate discrimination could occur level substrate binding cleavage focusing gamma secretase pair discuss recent observations suggesting global motions within substrate transmembrane helix may much important defining substrate local unraveling cleavage sites
last decades reproductive medicine observed improvement management outcome pregnancy connective tissue diseases systemic lupus erythematosus sle antiphospholipid syndrome aps however pregnancy related issues remain challenge patients routine clinical practice health professionals dealing sle aps need consider numerous aspects reproductive life patients pregnancy family planning fertility contraception cancer surveillance menopause new european league rheumatism recommendations women health family planning reflect need novel approach communication patient physician relationship preconception counseling essential ensure optimal pregnancy outcomes careful risk stratification involving disease activity organ involvement autoantibody profile use drugs previous pregnancy outcomes well ensure better preventive therapeutic strategies limit complications patients stable inactive disease low risk thrombosis adequate hormonal contraception menopausal replacement therapy recommended assisted reproductive techniques safely used patients anticoagulation low dose aspirin added positive antiphospholipid antibody titers menstruating women counseled possibility preserve fertility gonadotropin releasing hormone analogues receiving alkylating agents strict clinical serological laboratory multidisciplinary monitoring pregnancy mandatory early recognize effectively treat disease flares obstetric complications doppler ultrasonography fetal biometry regularly performed especially second third trimesters physicians recommend screening cervical dysplasia related human papillomavirus hpv infection especially immunosuppressive therapy hpv immunization used women stable inactive disease
present work demonstrate photocatalytic properties nanosized tio different levels zns loaded tio zns composites degradation organic dyes brilliant green methylene blue solar light irradiation process tio composites synthesized sol gel method prepared products subjected structural optical morphological characterizations results photocatalytic activity imply samples studied tio loaded optimum level zinc sulfur better able actively degrade due enhanced bet surface area reduced band gap low charge transfer resistance elsevier rights reserved
paper presents evaluation performance two instrumented sections geosynthetic reinforced soil wall high constructed using lateritic fine grained soil two sections identical layout nonwoven woven geotextile monitored comparison purposes unconfined tensile stiffness nonwoven geotextile three times smaller woven geotextile allowed direct evaluation effect soil confinement geotextile stiffness instrumentation used measure face displacements reinforcement displacement strains soil matric suction rainfall occurred construction facilitated evaluation effect soil wetting walls performance ultimate serviceability limit state analyses conducted gain insight performance two walls results show performance section reinforced nonwoven geotextile equivalent one reinforced woven geotextile even observed reduction matric suction rainfall sections overall deformations occurred construction negligible deformations observed service maximum face displacements measured lowest instrumented layer nonwoven geotextile section whereas highest layer woven geotextile section behaviours face displacement distributions result significant differences global stiffness sections design analyses field performance show soil confinement beneficial effect nonwoven geotextile stiffness significant contribution soil cohesion lateritic soil played important role behaviour nonwoven geotextile reinforced wall
silicon nanopore membranes snms compact geometry uniform pore size distribution demonstrated remarkable capacity hemofiltration advantages could potentially used hemodialysis present initial evaluation snm mechanical robustness diffusive clearance hemocompatibility parallel plate configuration mechanical robustness snm demonstrated exposing membranes high flows min pressures diffusive clearance performed albumin solution whole blood blood dialysate flow rates min hemocompatibility evaluated using scanning electron microscopy immunohistochemistry hours extracorporeal porcine model pressure drop across flow cell min mechanical testing showed snm could withstand without fracture urea clearance show appreciable decline blood versus albumin solution extracorporeal studies showed blood successfully driven via arterial venous pressure differential without thrombus formation bare silicon showed increased cell adhesion fold increase fold increase polyethylene glycol peg coated surfaces tissue plasminogen factor platelet adhesion respectively initial results warrant design development fully scaled snm based parallel plate dialyzer renal replacement therapy
background interventions alcohol use disorders auds hiv infected individuals primarily targeted hiv risk reduction improved antiretroviral treatment adherence however reduction alcohol use important goal alcohol use affects key factors may influence treatment course outcome study authors aim administer adapted intervention auds reduce alcohol use people living hiv aids plwha methods study cluster randomised controlled trial hiv care clinics motivational interviewing cognitive behavioural therapy based intervention auds developed adaptation piloted zimbabwe administered plwha auds recruited hiv clinics intervention administered sessions hiv clinics intervention compared equal attention control form world health organization mental health gap action programme mhgap guide adapted zimbabwean context general function quality life adherence highly active antiretroviral treatment haart secondary outcomes booster sessions administered groups months respectively primary outcome measure alcohol use disorder identification test audit score world health organisation disability assessment schedule whodas world health organisation quality life whoqol hiv viral load counts secondary outcome measures outcome assessments administered baseline months moderating factors perceived social support people cope difficult situations post traumatic exposure experience assessed baseline trained research assistants recruit participants outcome assessors trained administering outcome moderating tools blinded treatment arms allocated participants however principal investigator participants intervention staff unblinded data analysed using stata version primary secondary outcomes measured four time points baseline months respectively participants included analysis primary secondary outcome measures mean audit scores compared groups using student tests multilevel logistic regression analysis performed binominal variables multilevel linear regression continuous variables descriptive statistics computed baseline follow assessments discussion study first address problematic alcohol use plwha zimbabwe seeks use local resources delivering modified brief evidence based culturally contextualised intervention study results determine effectiveness adapting psychological interventions auds hiv infected adults using task sharing framework
study evaluated strategy identifying scapulothoracic orientation using bilateral ray scans scapula models subject specific scapula models scaled general model utilized scapulothoracic orientations obtained rays compared motion capture data subjects consisted skeletal model human torso ten real bone scapulae retroreflective markers placed scapulae three marker triad placed trunk marker positions recorded using eight camera motion capture system biplane ray system eos imaging used collect two orthogonal images skeleton markers custom software created matching process results indicated matched orientations compared favorably motion capture orientations rmse errors ranging degrees degrees mean error degrees proposed strategy shown accurate subject specific models scaled general model ipem published elsevier ltd rights reserved
background aim emotional dysregulation frequent feature attention deficit hyperactivity disorder adhd observed dysregulation profile deficient emotional self regulation desr profile oppositional defiant disorder conduct disorder odd comorbidity prevalent adhd known related first line treatment adhd includes psychostimulants effects well studied study aimed evaluate outcomes methylphenidate mph treatment adhd odd cases methods total adhd odd patients mean age years treated mph year also parents cases recruited parent training program initiated first month mph treatment symptom severity assessed baseline month turgay diagnostic statistical manual mental disorders fourth edition based child adolescent behavior disorders screening rating scale parent form children depression inventory child behavior checklist years parental acceptance rejection questionnaire mother form results emotional dysregulation desr present cases conduct disorder significantly higher patients whereas odd significantly higher desr non groups symptoms adhd significantly improved year mph treatment improvement independent improvement adhd symptoms parent training conclusions emotional dysregulation highly prevalent disruptive behavioral disorders odd comorbid adhd mph treatment effective independently clinical determinants
background lego therapy uses children natural interest play help motivate behavioural change may effective teaching tool increase social competency communication skills although literature growing synthesized objectives review literature role lego therapy social skills inclusion among children youth autism spectrum disorder asd methods scoping review conducted involving comprehensive searches international databases eligible articles included youth aged younger asd empirical research lego therapy interventions published peer reviewed journal conference proceedings dissertation results studies identified articles involving participants aged mean age years across five countries met inclusion criteria although outcomes lego therapy varied across studies studies reported least one improvement social communication skills building friendships improved social interactions social competence asd specific behaviors belonging family relationships coping reductions playing alone conclusions although lego therapy shows promise intervention children youth asd rigorously designed studies needed fully understand impact elsevier inc rights reserved
employers mainly operate international context interact multicultural environment want look employees possess emotional competences influence ease relationships people allow better social cohesion emotional self control alphabetisation emotional states work together personal benefit contrary expectations needs competences increasing number specialists state emotional intelligence central variable affects leaders performance study carried sugar factory tried characterise internal environment organisation relationships dominate order identify understand situation organisation confronted terms relationship managers subordinates empathy nonverbal communication self control handling relationships emotional intelligence tried provide exploratory evidence effects emotional intelligence leaders followers terms performance results work satisfaction authors published elsevier
objectivesto understand outcomes transurethral resection prostate turp transurethral laser incision prostate tulip treatment bladder outlet obstruction men high levels functional dependence poorly understood designretrospective cohort study settingu nursing homes nhs participantsmale residents aged older underwent turp tulip united states measurementschanges activities daily living adls foley catheter status survival months surgery examined multivariate regression used determine risk foley catheter year surgery resultssixty one percent cohort foley catheter procedure men foley catheter baseline foley catheter foley catheter died year procedure foley catheter baseline risk ratio confidence interval poor baseline functional status individuals worst quartile function associated greater risk foley catheter year conclusionpoor baseline functional status foley catheter preoperatively associated greater risk turp tulip failure measured presence foley catheter year preoperative measurement adls may aid surgical decision making population
among many legal professionals memory researchers exists assumption susceptibility false memory decreases age misinformation experiments show conditions focus meaning experiences children always susceptible suggestion induced false memories begin presenting short overview previous developmental false memory studies majority found susceptibility misinformation decreases age experiment year olds year olds adults received video confronted misinformation related nonpresented details older children adults higher misinformation acceptance rates younger children experiment replicated finding adding younger child group year olds experiments used new material found susceptibility misinformation increased age together experiments show children memory accuracy necessarily inferior adults
three dimensional virtual worlds dvw growing fast number users used diverse purposes collaboration dvw used good results due features immersion interaction capabilities use avatar embodiment physical space particular cases avatar embodiment physical space features support nonverbal communication impact collaboration well known work present initial steps creation protocol case study research aiming assert tool collect data nonverbal communication influences collaboration dvw define propositions units analysis pilot case validate
present study two novel dominant genera advenella kashmirensis desulfovibrio aminophilus consortium confirmed illuminamiseq used anode side microbial fuel cell reactor find influence cathode environment cell performance model terminal electron acceptor tea kmno different phs used cathode side oxidation peak obtained agci corresponding cyclic voltammogram confirms complete mineralization sulphate biogenic elemental sulphur accordance microbial community higher cathodic detrimental effect cell performance power density reduced half aqkmno catholyte solution resistance found low aqkmno ohm high ohm aqkmno corroborates highest power density obtained aqkmno buffering catholyte provided stability system lowest internal resistance ohm comparable performance highest current density power density obtained aqueous kmno developed consortium successfully utilized microbial fuel cells simultaneous electricity generation wastewater treatment elsevier rights reserved
compared hydrostatic hydrodynamic model non hydrostatic hydrodynamic model accurately simulate flows feature vertical accelerations model low computational efficiency severely restricts wider application paper proposes non hydrostatic hydrodynamic model based multithreading parallel computing method horizontal momentum equation obtained integrating navier stokes equations bottom free surface vertical momentum equation approximated keller box scheme two step method used solve model equations parallel strategy based block decomposition computation utilized original computational domain subdivided two subdomains physically connected via virtual boundary technique two sub threads created tasked computation two subdomains producer consumer model thread lock technique used achieve synchronous communication sub threads validity model verified solitary wave propagation experiments flat bottom slope followed two sinusoidal wave propagation experiments submerged breakwater parallel computing method proposed found effectively enhance computational efficiency save computation time compared serial computing parallel acceleration rate acceleration efficiency approximately respectively parallel computing method makes contribution popularization non hydrostatic models
objective purpose study overview current approach psoriatic arthritis psa group italian rheumatologists methods rheumatologists around italy asked participate survey give opinion number statements made panel rheumatologists experts psa survey conducted two rounds using delphi like method two rounds yielded consensus management psa results fifty rheumatologist rheumatology centres participated survey proposed statements reach concordance threshold main results survey diagnosis psa made using caspar criteria clinical judgment features psoriatic disease relevant assessment therapy psa treatment recommendations taken account available biological agents may used bio naive patients anti drug antibody testing still used daily practice switching swapping useful options case bio failure lack loss efficacy swapping considered best choice case bio failure due adverse events conclusion results survey showed comprehensive evaluation patient therapy choice based patient clinical features evidence drug efficacy safety considered current best care psa patients
semimembranosus tendon ruptures rare often associated involvement cruciate ligaments present year old american football player sustained complete rupture semimembranosus tendon near insertion associated avulsion fracture conjoint attachment lateral collateral ligament lcl biceps femoris intact cruciate ligaments menisci practice scene immobilized taken hospital immediately diagnosis reached radiographs mri affected knee obtained semimembranosus tendon avulsion biceps femoris insertion repaired surgically also review literature previously reported cases distal hamstring injuries
previous study showed dimerized translationally controlled tumor protein dtctp plays role pathogenesis allergic diseases asthma allergic rhinitis mer peptide called dtctp binding peptide dtbp binds dtctp inhibits cytokine like effects therefore examined protective effects dtbp house dust mite induced atopic dermatitis like skin lesions nishiki nezumi cinnamon nagoya nga mice found topical administration dtbp significantly reduced like skin lesions formation mast cell infiltration nga mice similarly response seen protopic tacrolimus treated group treatment dtbp also decreased serum levels ige reduced content skin lesions inhibited expression mrnas interleukin macrophage derived chemokine mdc thymus activation regulated chemokine tarc thymic stromal lymphopoietin tslp findings indicate dtbp inhibits release cytokine also suppresses production proinflammatory cytokines like skin lesions nga mice inhibiting tctp dimer allergic responses therefore dtctp therapeutic target dtbp appears potential role treatment
paper presents new paradigm explicitly modeling harnessing data structure address inverse problems structural dynamics identification data driven health monitoring particular shown structural dynamic features damage information intrinsic within structural vibration response measurement data possesses sparse low rank structure effectively modeled processed emerging mathematical tools sparse representation compressed sensing low rank matrix decomposition completion well unsupervised multivariate blind source separation also discussed explicitly modeling harnessing sparse low rank data structure could benefit future work developing data driven approaches toward rapid unsupervised effective system identification damage detection well massive shm data sensing management copyright john wiley sons ltd
area efficient self trimming technique precision chopper stabilized instrumentation amplifier presented amplifier uses reconfigurable differential pair input stage automatically configured reduce mismatch differential pair suppressing chopper ripple confirm effectiveness proposed scheme complete calibration logic fabricated standard cmos achieves active area less offset voltage input referred noise current consumption noise efficiency factor amplifier
paper novel hybrid many optimizing liaisons mol teaching learning based optimization tlbo mol tlbo based optimization integrated hybrid renewable energy sources ihres proposed techno economic socio analysis ihres consists wind turbine battery storage banks diesel generator methodology constructed using meteorological data renewable energy laboratory electrical engineering department manit bhopal situated madhya pradesh india optimal sizing ihres done basis solar irradiation wind speed demand load reliability index loss load probability lolp emission diesel generator three different crystalline silicon modules considered ase based efg kyocera based wafer astro power thin film results show gives better result compared two wind battery combination annual cost system acs evaluated using proposed hybrid mol tlbo mol tlbo algorithm supremacy suggested mol tlbo hybrid method optimal sizing hybrid system proved comparing results optimization techniques tlbo itlbo pso mol sga finally seen mol tlbo based techno economicsocio analysis ihres exhibit superior performance fast compared sga pso tlbo itlbo mol elsevier rights reserved
areas within agricultural field season often differ crop productivity despite cropping history crop genotype management practices one hypothesis abiotic biotic factors soils differ areas resulting productivity differences study bulk soil samples collected high low productivity area within six agronomic fields illinois quantified abiotic biotic characteristics extracted dna bulk soil samples shotgun sequenced logistic regression analyses resulted significant association crop productivity soil characteristics principal coordinate analysis constrained correspondence analysis showed crop productivity explained major proportion taxa variance bulk soil microbiome metagenome wide association studies mwas identified bradyrhizodium gammaproteobacteria higher productivity areas actinobacteria ascomycota planctomycetales streptophyta lower productivity areas machine learning using random forest method successfully predicted productivity based microbiome composition best accuracy order level study showed crop productivity differences associated bulk soil microbiome composition highlighted several nitrogen utility related taxa demonstrated merit mwas machine learning first time plant microbiome study
reservoir diagenetic process petroleum charge histories cretaceous bashijiqike formation kuqa depression tarim basin studied using integrated petrographic fluid inclusion reservoir diagenesis basin modeling approach suite techniques used investigation including optical microscopy scanning electron microscope sem ray diffraction xrd fluorescence spectroscopy microthermometry laser raman microspectroscopy workflow comprises petrographic characterization reservoir sandstone identification fluid inclusion assemblages construction diagenetic history reservoir sandstone reference hydrocarbon charge emplacement key diagenetic events identified include quartz overgrowths early calcite cementation dolomite cementation alteration kaolinite bitumen emplacement micro quartz ankerite cementation first diagenetic event characterized quartz overgrowths followed calcite dolomite cementation kaolinite ankerite cementation last diagenetic events coincided hydrocarbon charge emplacement three episodes hydrocarbon charge emplacement recorded diagenetic products fluid inclusions kbs formations first episode oil charge recorded early calcite cement trapped around second third episodes hydrocarbon charge recorded telo diagenetic ankerite trapped around timing oil emplacement determined fluid inclusion homogenization temperature basin modeling consistent formation order diagenetic minerals study thus demonstrated integrated analysis fluid inclusion reservoir diagenesis effective tool determining hydrocarbon charge emplacement history elsevier rights reserved
paper devoted outlines research project european union seventh framework programme grant venus european project working developing axial flux electrical machine electrical vehicle different possible topologies switched reluctance topology chosen order validate design tools uncommon topology comparison finite element analyse together experimental validation performed results comparison summarized paper
method multiple scales global perturbation technique resulted useful perturbed ordinary differential equations characterized disparate time scales general principle behind method solution differential equation uniformly expanded terms two independent variables referred time scales article present mathematical object based poisson series apply method multiple scales via specific symbolic computation copyright john wiley sons ltd
based numerical simulation method research optimal design cutting excavation control conducted zhonglou mountain landslide north shaanxi china three excavation slope angles namely degrees degrees degrees chosen numerical simulation calculation comparative analysis condition long period rainstorm results analysis show excavation slope angle degrees relatively dangerous condition long period rainstorm excavation slope angle degrees save excavation volume per meter width compared angle degrees also safer stable therefore concluded angle degrees safest economical excavation slope angle cutting excavation control method provides technical reference control similar landslides also certain scientific value practical significance engineering
objectives study aimed develop performance assessment tool history taking components medical evaluation physical abuse young children determining consensus based injury history social components documentation identifying preliminary performance standards assessing current level specific performance using created tools evaluating reliability validity created tools methods physical abuse assessment tool phaat developed steps modified delphi survey used identify injury history social components documentation medical evaluation physical abuse level specific novice competent expert practice standards minimum passing scores created using identified components via angoff method evaluate validity reliability level specific performance phaat chart review consecutive cases levels performed results seventy one child abuse pediatricians social workers participated modified delphi survey child abuse pediatricians social workers participated angoff method resulting phaat included checklists use based presence absence history injurious event one way analysis variance shows significant differences performance based team level indicating construct validity intrarater interrater reliability evaluations showed strong moderate strong intraclass correlation coefficient correlations respectively conclusions initial evaluation suggests phaat may reliable valid practice assessment tool medical evaluation physical abuse
pathogenesis irritable bowel syndrome ibs thought largely psychogenic origin understood multifactorial one reasons paradigm shift realization gut dysbiosis including small intestinal bacterial overgrowth sibo causes ibs symptoms patients ibs controls sibo wide variations prevalence might result population differences ibs diagnostic criteria importantly methods diagnose sibo although quantitative jejunal aspirate culture considered gold standard diagnosis sibo noninvasive hydrogen breath tests popular although glucose hydrogen breath test highly specific sensitivity low contrast early peak criteria lactulose hydrogen breath test highly nonspecific female gender older age diarrhea predominant ibs bloating flatulence proton pump inhibitor narcotic intake low hemoglobin associated sibo among ibs patients several therapeutic trials targeting gut microbes using antibiotics probiotics demonstrated symptoms patients ibs originate brain rather gut providing support micro organic basis ibs recent proof concept study showing high frequency symptom improvement patients ibs sibo supports hypothesis
drugs abuse stimulate striatal dopamine release activate reward pathways study examined impact alcohol cannabis marketing reward circuit alcohol cannabis users sober intoxicated predicted alcohol cannabis marketing would increase striatal activation sober reward sensitivity would less alcohol cannabis intoxication heavy alcohol regular cannabis users participated mixed factorial study involving administration alcohol placebo alcohol group cannabis placebo cannabis group non drug users served group reference brain activation exposure alcohol cannabis marketing movies measured using functional magnetic resonance imaging compared groups sober compared placebo intoxicated implicit alcohol cannabis cognitions assessed means single category implicit association test alcohol cannabis marketing significantly increased striatal bold activation across groups sober striatal activation however decreased intoxication alcohol cannabis implicit associations cannabis marketing cues significantly positive alcohol cannabis users compared non drug using controls public advertising alcohol cannabis use elicits striatal activation brain reward circuit reduction marketing would reduce brain exposure reward cues motivate substance use conversely elevated dopamine levels protect reinforcing potential marketing
congenital rickets term given fetus born clinical features rickets born biochemical evidence rickets without obvious clinical features still considered occult congenital rickets affected babies disease intrauterine rachitic environment calcium trans placental pump prevents fetus clinical features rickets may present hypocalcemia days birth later florid features rickets congenital rickets cases born florid features reported last years divided two groups first due severe maternal osteomalacia bones decalcified enough calcium pumped fetus another group newborn babies hypocalcemic due maternal diseases malabsorption celiac disease pre eclampsia prematurity inherited rickets cases per part syndromes considered congenital rickets cases seen region due maternal vitamin deficiency symptoms becoming obvious infants breastfed may present hypocalcemic convulsions craniotabes review congenital rickets aim shedding light potentially acute disease needs attention awareness neonatal period avoid rare serious complications cardiomyopathy myelofibrosis complications hypocalcemic convulsions congenital rickets cases seen simulate tip ice burg prevention important issue especially tremendous urbanization tall buildings living sun deprived flats commonest type residence leading increasing incidence maternal osteomalacia rickets
turbocharger key enabler energy conservation internal combustion engine ice turbine turbocharger fed highly pulsating flow due reciprocating engine resulting different behavior steady conditions paper investigates behavior mix flow turbine pulsating conditions via analytical model house developed unsteady code ondas firstly analytical model unsteadiness based mass flow imbalance built mechanism unsteady behavior discussed details next unsteady model turbine pulsating conditions established validated experimental results finally influence frequency magnitude product unsteady behavior turbine investigated reduced order model exploration analytical model investigation clearly demonstrates impact pulsating flow unsteady performance unveils mechanism unsteadiness turbine pulsating conditions elsevier ltd rights reserved
objective aim aim report investigate effect ventriculoperitoneal shunt insertion treatment hydrocephalus thyroid hormones first months life methods thyroid stimulating hormone tsh free free levels compared days preoperatively days postoperatively birth ventriculoperitoneal shunt inserted hydrocephalic newborns healthy newborns results tsh level days higher hydrocephalic patient group compared control group value significantly decreased days ventriculoperitoneal shunt inserted newborns compared control group significant differences time points values patient group tsh values control group conclusion propose ventriculoperitoneal shunt inserted early period life may beneficial effects thyroid hormones karger basel
epidermal differential complex edc proteins filaggrin involucrin loricrin play key roles protect mucosal surface invading pathogens eosinophilic esophagitis eoe allergic gastrointestinal disease features eosinophilic infiltration esophageal mucosa though function edc proteins pathogenesis remains unknown aim study investigate possible differences edc protein expression epithelium esophagus pharynx tongue furthermore examined expression esophageal specimens obtained patients eoe evaluating edc protein expression epithelium different locations enrolled patients underwent surgical resection esophageal pharyngeal tongue squamous cell carcinoma pathological samples used analysis expression immunohistochemistry addition samples obtained patients eoe healthy subjects compared esophageal epithelial expression edc proteins epithelium samples obtained esophagus pharynx tongue presence edc proteins confirmed immunohistochemistry analysis findings though expression patterns notably different comparison epidermis samples eoe patients expression involucrin dramatically regulated esophageal mucosa whereas regulation filaggrin loricrin reach statistically significant level edc protein expression clearly detected pharyngoesophageal epithelium samples involucrin alone markedly reduced patients eoe
introduction butyrylcholinesterase bche involved metabolism endogenous lipids xenobiotics esters carboxylic phosphoric acids butyrylcholinesterase activity associated inflammation oxidative stress changes activity enzyme observed various diseases liver cirrhosis diabetes neurodegenerative disease others material methods study involved patients chronic obstructive pulmonary disease copd healthy subjects copd patients divided according severity disease applying classification copd based gold standards forced expiratory volume fev fev forced expiratory volume fvc ratio control group comprised blood samples collected healthy subjects without concomitant diseases related respiratory system butyrylcholinesterase activity lipid peroxidation total antioxidant capacity tac determined blood plasma results significant decrease activity bche associated increase lipid peroxidation decrease total antioxidant capacity observed blood plasma patients chronic obstructive pulmonary disease conclusions study shows first time activity bche blood plasma patients diagnosed chronic obstructive pulmonary disease considerably reduced compared healthy subjects changes accompanied decrease tac increase lipid peroxidation suggests may related oxidative stress induced copd disease
background polycythemia vera found wide range hematopoietic tissue disorders rarely concomitant renal abnormality knowledge one available report patient polycythemia vera concomitant renal angiomyolipoma report cover clinical course rare finding objectives report presentation clinical course patient polycythemia vera concomitant right renal angiomyolipoma methods retrospectively reviewed medical records patient polycythemia vera presented renal angiomyolipoma results patient presented right renal mass polycythemia vera diagnosed point mutation gene janus kinase mass diagnosed renal angiomyolipoma histopathology partial nephrectomy prescribed low dosage hydroxyurea without return erythrocytosis year conclusions polycythemia vera responded well low dosage hydroxyurea controlled erythrocytosis removing renal mass
one pressing needs vis design allow even larger mirrors jwst primary affordable cost report results nasa innovative advanced concepts phase study project called precise extremely large reflective telescope using reconfigurable elements aperture idea deploy continuous membrane like mirror mirror figure corrected deployment bring better equal lambda deviations prescribed mirror shape basic concept new new use different approach classical piezoelectric patch technology instead concept based contiguous coating called magnetic smart material msm deployment magnetic write head move non reflecting side mirror generate magnetic field produce stress msm correct mirror deviations prescribed shape
purpose study understand relationships mother placenta child system case hematogenous thrombophilia thrombotic state readiness pregnant women materials methods research group consisted patients divided two subgroups subgroup included women pregnant subsequently obstetric patients subgroup included infants perinatal center state novosibirsk regional clinical hospital days life newborns sub group underwent hemostatic system assessment healthy newborns somatically healthy mothers without thrombophilia included control group assessment hemostatic system carried determine performance reference values results relationships health condition newborns hemostatic system disorders mothers thrombotic state readiness hematogenous thrombophilia morphohistological changes placenta studied researchers analyzed labour delivery records pathomorphological examination placenta neonatal records assessed hemostatic system number complications detected gestational process early neonatal period correlation analysis established relationship mother placenta child system number factors affecting children health outcomes correct mentioned abnormalities preventive measures taken allow avert development perinatal complications case hematogenous thrombophilia thrombotic readiness
aspergillus fumigatus opportunistic fungal pathogen primary causative species invasive aspergillosis systemic disease associated high mortality rates treatment invasive fungal infection relies limited number antifungal drug classes order extend spectrum antifungal drugs novel target structures identified mitochondria encounter structure ermes recently discovered tether links mitochondria endoplasmic reticulum potential drug target based absence metazoa recently shown ermes important fitness immune evasion pathogenic yeast candida albicans studied role four ermes core components mdm mdm mdm mmm pathogenic mold fumigatus construction characterizing conditional mutants four core components deletion mutants mdm mdm show component significant importance growth fungal pathogen markedness individual mutant phenotypes differed slightly components important maintenance mitochondrial morphology intra organellar distribution nucleoids characterization mmml ermes mutant galleria mellonella infection model indicates ermes contributes virulence fumigatus results demonstrate pharmacologic inhibition ermes could exert antifungal activity important pathogen elsevier gmbh rights reserved
different clinical stages observed idiopathic parkinson disease non motor symptoms define prodromal period particular whereas motor symptoms bradykinesia rigidity resting tremor postural instability mandatory diagnosis important non motor symptoms olfactory dysfunction constipation depression sleep disturbances corresponding clinical course braak staging system postulates neuropathological process starts enteric nervous system ens gut olfactory bulb parkinson pathology spreads transsynaptic cell cell transfer via sympathetic parasympathetic nervous system rostrocranial direction central nervous system reached typical neuropathological changes selective degeneration dopaminergic neurons substantia nigra pars compacta formation lewy bodies reactive gliosis progressive central neurodegeneration appear evidence clinical pathological animal studies supporting hypotheses summarised review article synuclein specific pathology found olfactory bulb ens submandibular gland intermediolateral nucleus spinal cord dorsal motor nucleus vagus nerve animal model mice treated pesticide rotenone chronically intragastrically could almost completely reproduce typical pathological clinical features well development chronological regional sequence
detection degradations resulting failures electronic components systems paramount importance complex industrial applications including nuclear power reactors aerospace automotive space applications increasing acceptance importance detection failures degradations electronic components prospect system level health monitoring make key contribution detecting predicting impending failures paper describes parametric system identification based health monitoring method detecting aging degradations passive components switch mode power converters smpcs nonparametric system response identified perturbing system optimized multitone sinusoidal signal order mvs parametric system model estimated nonparametric system response using recursive weighted least square wls algorithm finally power stage component values including parasitics extracted numerator denominator coefficients based assumed laplace system model extracted component values provide direct diagnostic information degradation anomalies components system proof concept initially verified simple point load pol converter methodology applied topologies smpc
ethnography qualitative research method used study people cultures largely adopted disciplines outside software engineering including different areas computer science ethnography provide depth understanding socio technological realities surrounding everyday software development practice help uncover practitioners also despite potential ethnography widely adopted empirical software engineering researchers receives little attention related literature main goal paper explain empirical software engineering researchers would benefit adopting ethnography achieved explicating four roles ethnography play furthering goals empirical software engineering strengthen investigations social human aspects software engineering inform design software engineering tools improve method process development inform research programmes article introduces ethnography explains origin context strengths weaknesses presents set dimensions position ethnography useful usable approach empirical software engineering research throughout paper relevant examples ethnographic studies software practice used illustrate points made
aimto examine medication use among patients dementia towards end life evaluate appropriateness medication use using nationwide database methodsusing taiwan national health insurance research database identified people dementia died person dementia data medication use last month outpatient setting month baseline last hospitalization hospitalization baseline death retrieved study medications interest selected according consensus recommendation included five categories defining appropriateness always sometimes rarely never appropriate well consensus multivariable logistic regression carried analyze determinants use never appropriate medications resultsapproximately study participants prescribed medications categorized never appropriate last month life outpatient settings significantly lower baseline month similar pattern identified last hospitalization death older age associated lower likelihood prescribed never appropriate medications age aor age aor contrast patients history diabetes mellitus aor associated higher likelihood prescribed never appropriate medications conclusionsthis first study sophisticatedly describe medications use particularly according appropriateness palliative care asian people dementia end life approximately patients prescribed never appropriate medications end life deserves study evaluate clinical impact quality care geriatr gerontol int suppl
distributed generation deployed radial distribution networks changes steady state transient behavior analyze potential impact distribution network study models distribution network enhanced system particularly photovoltaic system digital simulation electrical network calculation program digsilent open distribution system simulator opendss first case study study initially examines load models voltage regulators single three phase transformers provided digsilent opendss adds single phase system ieee bus test feeder compares steady state power flow solutions ieee bus test feeder calculated digsilent calculated opendss second case study study also models sufficiently complex feeders feeder number buses test distribution network developed digsilent used various fields analyzing steady state transient behavior enhanced distribution systems
recent years along increased awareness ecology design urban parks shifting towards providing ecological services however dearth case studies new typology article explores characteristics ecosystem service oriented urban park esoup establishes post occupancy evaluation system using tianjin qiaoyuan park case study identifies problems solutions involved processes design construction management maintenance
anti tumor necrosis factors anti tnfs class biologic disease modifying anti rheumatic drugs indicated treatment moderate severe psoriatic arthritis psa refractory patients commonly managed switching one anti tnf another assess evidence effectiveness anti tnf cycling psa patients systematic review literature conducted medline embase indexed english language publications systematically searched studies assessing real world effectiveness outcomes anti tnf cycling psa patients citations identified studies included conducted europe six seven studies testing lines found significant differences effectiveness earlier subsequent lines anti tnf therapy first line therapy yielded better results compared second line therapy significant differences observed second third line anti tnf treatments study multivariate regression testing predictors response danish registry patients less likely respond american college rheumatology response second anti tnf course safety rather lack effect caused switch odds ratio respectively effectiveness anti tnfs second line later reported small number real world studies psa patients subsequent treatment lines may associated less response measures research needed quantify effectiveness sequential anti tnf lines progressive populationaeuroe compare effects responses drugs different mechanisms action
inferring beliefs social emotions others different neural substrates possibly different roles pathophysiology different clinical phases schizophrenia current study investigated neural basis inferring others beliefs social emotions individual concepts subjects ultra high risk psychosis uhr patients schizophrenia healthy controls brain activity significantly differed normal left superior temporal sulcus sts inferior frontal gyrus ifg schizophrenia group inferring others beliefs whereas uhr group middle schizophrenia healthy control groups brain activity inferring others social emotions significantly differed left sts right ifg among individuals uhr however significant difference schizophrenia group contrast brain activity differed left ifg schizophrenia uhr groups inferring social emotion regarding difference direction abnormality uhr schizophrenia groups characterized hyper sts hypo ifg activations inferring others beliefs emotions findings might reflect different aspects pathophysiological process different clinical phases psychosis
cannabis use disorder cud occurs anxiety disorders high rates little known mechanisms linking cud anxiety disorders one theoretically driven perspective individuals anxiety disorders may apt use fsbs behaviors may effective decreasing anxiety short term maintain even exacerbate anxiety long term perpetuate cannabis use despite cannabis related problems present study tested whether fsb use explained relation anxiety symptom severity cannabis quantity related problems among adults cud comorbid anxiety disorders seeking outpatient cud treatment results indicated fsb frequency significantly related anxiety symptom severity cannabis problem severity cannabis quantity anxiety symptom severity indirectly via fsb frequency related cannabis problem severity cannabis quantity novel findings suggest frequent use fsbs may play important role cannabis problem severity among individuals cud anxiety disorders elsevier ltd rights reserved
one key limiting factor groundwater remediation contaminant sequestered pores whose contents mix well bulk flow mixing well connected pores whose volume flushed water flows aquifer poorly connected pores pores whose volume exchange readily water flows aquifer primary concern steady flow contaminants effectively trapped poorly connected pores transferred molecular diffusion slow mixing process pore types bottleneck remediation present novel rapidly pulsed pumping method increases mixing pore types context pump treat remediation common remediation practice rapidly pulsed pumping increase flow causes deep sweep pushes flow poorly connected pores sweeps sequestered contaminants decrease flow causes vortex ejection causes vortex within poorly connected pore emerge contaminant actions modeled computational fluid mechanics elucidate individual mechanisms determine function interact cleanup single multiple poorly connected pore systems simulated show acceleration possible technique decrease time cost needed remediate contaminated aquifers united states estimated exceed trillion since rapidly pulsed pumping method enhances mixing well connected poorly connected pores applied remediation schemes situ methods
study question effect ovarian activity preceding intake ulipristal acetate upa starting combined oral contraceptive coc mid late follicular phase cycle summary answer study shows upa affect ability coc induce ovarian quiescence known already upa progesterone receptor modulator available emergency contraception theory upa could alter effectiveness hormonal contraception started immediately following vice versa current guidelines regarding quick starting coc following upa based expert opinion study design size duration double blind randomized placebo controlled trial conducted three separate sites edinburgh scotland stockholm sweden groningen netherlands month period healthy female volunteers randomized take either upa identically packaged placebo mid cycle lead ovarian follicle determined transvaginal ultrasound imaging participants randomized computer generated randomization schedule allocated sequential sealed envelopes women started days coc following day study designed show non inferiority upa compared placebo terms proportion women attaining ovarian quiescence measured hoogland scoring system taking coc participants materials setting methods total women recruited three sites edinburgh stockholm groningen received either upa placebo main results role chance significant differences demographic characteristics women upa placebo groups among participants treated reached quiescence ovulated significant differences groups odds ratio reaching ovarian quiescence women reached quiescence done taking cocs days limitations reasons caution main limitations study measurements follicle size blood tests performed every days possible determine actual day follicle rupture occurred women ovulated furthermore ultrasonography conducted number investigators sites may introduce error form inter observer variability measurements follicle growth finally findings study extrapolated combined hormonal methods contraception patch ring progestogen methods contraception wider implications findings study provides evidence suggest upa affect ability coc induce ovarian quiescence however study design determine whether coc affects ability upa delay ovulation study funding competing interest funding provided hra pharma paris france received funds conducting research studies lectures hra pharma director contract research organization dinox remaining authors declare conflicts interests
testing effect refers finding retrieval practice comparison restudy previously encoded contents improve memory performance reduce time dependent forgetting naturally long retention intervals include wake sleep delay influence memory contents differently fact sleep immediately encoding induce mnemonic benefit stabilizing strengthening encoded contents investigated series experiments whether sleep influences testing effect initial study categorized item material experiments paired associates experiment educational text material experiment subjects asked restudy encoded contents engage active retrieval practice final recall test conducted delay included diurnal wakefulness nocturnal sleep results consistently showed typical testing effects wake delay however testing effects reduced even eliminated sleep sleep benefited recall restudied items left recall retrieved items unaffected findings consistent bifurcation model testing effect kornell bjork garcia according distribution memory strengths across items shifted differentially retrieving restudying retrieval strengthening items much higher degree restudy basis model retrieved items already fall recall threshold absence sleep additional sleep induced strengthening may improve recall retrieved items
study aimed evaluate innovative workflow maxillofacial fracture surgery planning surgical splint designing maxillofacial multislice computerized tomography msct data dental cone beam computerized tomography cbct data obtained normal adults adults suffered fractures part cbct dentition image registered msct image use iterative closest point algorithm volume evaluation virtual splints designed registered msct images msct images object performed eighteen patients group operated without splint twenty one group patients group used splints designed according msct images registered msct images respectively authors results showed mean errors models ranged rms errors ranged fracture patients mean errors models ranged rms errors ranged normal adults patients group recovered occlusion patients group patients group reconstructed occlusion statistically significant difference msct images based splints volume registered msct splints volume patients msct images based splints volume statistically significantly distinct registered msct splints volume normal adults statistically significant difference msct images based splints volume registered msct splints volume patients normal adults occlusion recovery rate group better group group way integrating cbct images msct images splints designing feasible volume splints designed msct images tended smaller splints designed integrated msct images patients operated splints tended regain occlusion patients operated splints designed according registered msct images tended get occlusal recovered
objective increasing evidence implicates advanced paternal age offspring birth neuropsychiatric disorders advanced maternal age also associated schizophrenia neurodevelopmental disorders whereas younger maternal age linked behavioral disorders studies considered specificity associations respect comorbidity addition prior studies conducted clinical samples registries may reflect severe forms psychopathology aim research examine independent joint associations maternal paternal age specific subtypes psychopathology offspring pediatric sample adolescents emergent psychiatric syndromes method total youths aged years philadelphia neurodevelopmental cohort included analyses logistic regression models parental age predicting offspring psychopathology adjusted sociodemographic factors comorbid disorders results found younger parental ages generally associated increased rates offspring psychopathology controlling sociodemographic characteristics comorbidity younger maternal paternal ages associated behavior syndromes psychosis youth whereas advanced paternal age associated pervasive developmental disorders autism spectrum disorder pdd asd conclusion findings suggest younger older parental age birth associated specific forms psychopathology offspring persistence influence parental age control demographic factors index social environment suggests additional explanations findings examined future studies
objective present study reviews series patients underwent thyroid surgery eldoret kenya demonstrate feasibility conducting long term year outcomes research resource limited setting impact quality life recipient population inform future humanitarian collaborations study design case series chart review setting tertiary public referral hospital eldoret kenya subjects methods twenty one patients enrolled study period retrospective chart review performed adult patients underwent thyroid surgery humanitarian trips patients contacted mobile telephone medical history physical examination including laryngoscopy performed administered quality life questionnaire laboratory measurements thyroid function neck ultrasound obtained results mean follow months surgery subtotal thyroidectomy patients lobectomy patients hypothyroid postoperatively according serologic studies cases goiter recurrence malignancy patients reported postoperative symptomatic improvement collectively showed positive pre postoperative score differences conclusion although limited small sample size retrospective nature study demonstrates feasibility long term surgical quality life outcomes research resource limited setting low complication rates suggest minimal adverse effects performing surgery context despite considerable rate postoperative hypothyroidism accordance prior studies emphasizes need individualized longitudinal multidisciplinary care quality life score improvements suggest benefit recipient population
backgroundthe objective study compare overall survival patients undergo radical prostatectomy radiotherapy versus noncancer controls discern whether survival advantage according prostate cancer treatment impact selection bias results methodsa matched cohort study performed using surveillance epidemiology end results seer medicare linked database total patients ages years identified without significant comorbidity diagnosed localized prostate cancer received treatment treated surgery radiotherapy patients matched noncancer control cohort rates cause mortality occurred within study period compared cox proportional hazards regression analysis used identify determinants associated overall survival resultsof patients included analysis received radiation therapy underwent surgery improved survival patients underwent surgery hazard ratio confidence interval received radiotherapy hazard ratio confidence interval compared noncancer controls overall survival improved significantly treatment groups greatest benefit observed among patients underwent surgery log rank conclusionspopulation based data indicated patients prostate cancer received treatment either surgery radiotherapy improved overall survival compared cohort matched noncancer controls surgery produce longer survival compared radiation therapy results suggest inherent selection bias unmeasured confounding variables cancer american cancer society treatment localized prostate cancer using either surgery radiotherapy associated improved overall survival benefit compared noncancer controls inherent selection bias unmeasured confounding variables using cancer registry data
clinical practice need individualized selection antidepressants adequate dosage investigation pharmacokinetically relevant genes promising approach assist selection past years two commercially available tests subject advertisement test stada analyses variants cytochrome isoenzymes cypd cypc test hmnc brain health analyses variants abcb gene costs kits covered statutory health insurance therefore proposed patients invoiced directly form individual healthcare payment companies claim applying tests antidepressant treatment failure avoided patients respond faster antidepressant used claims based appropriate clinical trials either lacking reveal conflicting results hence routine use tests recommended accordance german guideline unipolar depression therapeutic drug monitoring tdm serum levels carried cases non response antidepressant adequate dosage duration rule costs tdm covered statutory health insurance cytochrome genotyping indicated serum level within expected range reasons explain discrepancy excluded many laboratories provide analyses individual cases costs reimbursed statutory health insurance research carried investigate importance abcb gene treatment antidepressants
child abuse refers actions non actions mediated immediately affect physical psychic integrity infant negatively influence normal physical emotional social development neglect represents willful failure either parent tutor assure child access healthcare system thus jeopardizing growth evolution field pediatric dentistry abuse neglect ultimately lead complex dento facial disabilities long term consequences pediatric dentist expected establish complex professional medical relations based clearly defined deontological principles continuously targeting child superior interest way dental practitioner may identify quite various situations according fundamental principle medical good action require involvement medical relation third responsible person accordingly child superior interest represent priority granting rights life health well case special protection potentially really dangerous situations child security well faced medical staff obliged announce specialized structures child assistance protection cases secondary principles professional medical confidentiality interdiction making public professional medical secret left aside type intervention physician patient relation characterized risks advantages derived promptness general even forceful methods protection children civilized community applied
paper presents active disturbance rejection control adrc based strategy applied track human gait trajectory lower limb rehabilitation exoskeleton desired human gait trajectory derived clinical gait analysis cga adrc total external disturbance estimated extended state observer eso canceled designed control law observer bandwidth controller bandwidth determined practical principles simulated proposed methodology matlab numerical simulation shows tracking error comparison estimated errors extended state observer two experimental tests carried prove performance algorithm presented paper experiment results show proposed adrc behaves better performance regular proportional integral derivative pid controller proposed adrc rehabilitation system capable tracking target gait accurately isa published elsevier ltd rights reserved
crystallographic properties fluorapatite fap polytetrafluoroethylene ptfe biomedical materials compared materials contain fluorine casually belong hexagonal crystal system interesting fap inorganic ionic crystal ptfe organic covalent bond crystal generally fluorine contributes physicochemical stability cases biocompatibility crystal structure fap initially analyzed naray szabo although analysis hydroxyapatite hap markedly delayed computer graphics display demonstrated fluoride ions serve stabilize hydroxyapatite crystals prevent dental caries hand ptfe crystal analysis reported bunn howells ptfe temperature pressure phase diagram accepted years complicated insufficient ptfe delicately changes phase near room temperature although glance appears simple form compared dna
sacroiliac joints sijs one common sites involved axial spondyloarthritis axspa studies histopathology sij group patients mononuclear cell infiltrates bone marrow fibrous tissue resembling pannus formation pathological features early sacroiliitis previous study undertook immunohistological evaluation features patients axspa biopsy specimens sij patients established ankylosing spondylitis patients nonradiographic axial spondyloarthritis axspa analyzed immunohistological method performed examine macrophages cells cells mononuclear cell infiltrates bone marrow observed patients axspa fibrous tissue observed patients established patients axspa macrophage cell cell infiltrates could detected bone marrow fibrous tissue bone marrow specimens axspa patients exhibited macrophage infiltrates exhibited cell infiltrates exhibited cell infiltrates among fibrous tissue specimens exhibited macrophage infiltrates exhibited cell infiltrates exhibited cell infiltrates addition macrophages cells cells also involved active sacroiliitis patients axspa
paper cellulose based electro active paper eapap energy scavenging transducer presented cellulose proven smart material exhibits piezoelectric effect specimens prepared coating gold electrodes sides cellulose film fabricated specimens tested base excited aluminum cantilever beam resonant frequency different tests performed single multiple parallel connected electrodes coated cellulose film maximum output voltage measured three electrodes connected parallel observed voltage output increases significantly area electrodes results concluded piezoelectricity cellulose based eapap used energy transduction application
paper present new cryptographic primitive called policy controlled signatures notion signer sign message attach policies verifier satisfies policies attached verify authenticity message type signature schemes many applications particular deal sensitive data signer want allow anyone unauthorized verify authenticity messages notion policy controlled signatures resembles similarities designated verifier signatures also used designate signature multiple recipients nevertheless shall demonstrate notion policy controlled signatures generalize notion designated verifier signatures concrete scheme secure model also provided furthermore also present extension universal policy controlled signature extended notion combine idea universal designated verifier signatures policy controlled signatures allow flexible delegations also provide concrete scheme secure model
various psychiatric problems adolescence early adulthood shown associate criminal behaviour study association personality disorders pds criminal behaviour examined adolescents treated psychiatric hospitals study sample consisted adolescents age admitted acute psychiatric impatient care april march crime data obtained finnish legal register centre september schedule affective disorder schizophrenia school age children present lifetime sads used assess psychiatric diagnoses adolescence information pds early adulthood based follow information psychiatric treatments either inpatient settings end extracted national care register health care provided finnish national institute health welfare total subjects committed crime women likelihood violent criminality significantly increased borderline also associated conduct disorder child welfare placement parent substance use disorder men association observed kind criminal behaviour significant predictors violent criminality males conduct disorder substance use disorder special services school females borderline showed increased risk violent offending suggests borderline potential explanatory factor violent assaults females highlights importance recognizing risk violence young women borderline elsevier ireland ltd rights reserved
molecular routine diagnostics bcr abl negative myeloproliferative neoplasms mpn currently focusses mutations jak calr mpl recent years recurrent mutations mpns identified several genes present validation next generation sequencing ngs based gene panel use mpn analysed mutation status genes mpn patients essential thrombocythaemia primary myelofibrosis pmf polycythaemia vera found two mutated genes patients moreover significantly mutated splicing genes sfb srsf uaf present pmf mutated genes patient compared mutations splicing genes found additionally chromatin modification genes asxl ezh frequently mutated pmf patients significantly lesser extent contrarily dna methylation genes dnmta idh idh tet mutated often less frequently pmf without reaching statistical significance results demonstrate feasibility utility ngs based panel diagnostics mpn patients bearing two mutated genes prognostic relevance needs studies
several studies cognition bipolar disorder developed last decade neuropsychological evaluation attention patients fundamental since alterations attention affect cognitive functions evaluate performance patients attention tests varies according phase disease verify differences attention comparing patients normal controls study included patients ages years euthymic manic depressive besides normal controls subjects evaluated though hamilton depression scale young mania rating scale global assessment functioning bipolar version cgi attention evaluated neuropsychological battery normal controls better performance selective attention tests patients differences found among manic depressive euthymic phases attention markedly impaired nevertheless results study imply severity attention deficit patients varies according decease phase
high prevalence potentially traumatic events subsequent associated mental health problems impaired functioning need graduate training trauma psychology national survey conducted north american doctoral programs psychology ascertain current status training trauma training directors sent email invitations asked complete web based survey total responded adequate information program included analyses offered trauma psychology course well practicum specifically working traumatized populations commonly cited barriers addressing trauma limited capacity elective courses little time resources attention trauma issues important development competent professional psychologists ways doctoral programs facilitate development knowledge skills attitudes trauma psychology discussed
low back pain lbp recognized leading cause disability worldwide lumbar instability considered important mechanism lbp one potential contributor lumbar stability trunk muscle reflex activity however due differences experimental paradigms used quantify trunk mechanics trunk reflexes remains unclear extent reflex pathway contributes overall lumbar stability goal work determine extent reflexes various trunk muscles elicited small continuous perturbations normally used quantify trunk mechanics electromyographic emg activity measured bilaterally trunk extensor muscles trunk flexor muscles four epochs following perturbation reflex activity seen muscles muscle epoch combinations showed significant reflex response either perturbations forward backward direction however reflex emg activity correlate mechanical estimates reflex response thus even though reflexes indeed elicited small perturbations used quantify trunk mechanics exact contribution overall lumbar stability remains unknown elsevier ltd rights reserved
geographical information systems gis often used assess monitor environmental impacts caused mining activities aim work develop new application produce dynamic maps monitoring temperature variations self burning coal waste pile gis open source environmentgis ecoal freely available performance application evaluated distributed temperature measurements gathered pedro cova portugal coal waste pile order obtain temperature data optical fiber cable disposed affected area pile location stakes acting precisely located control points temperature measurement monthly data set july min interval fed application video composed several layouts temperature measurements created allowing recognizing two main areas higher temperatures field observations also allow identification zones however identification area higher temperatures top studied area possible visualization images created application generated videos make possible dynamic continuous visualization combustion process monitored area
present study experimental investigation conducted characterize unsteady vortices turbulent flow structures around twin box girder tbg bridge deck models without cross beams oncoming wind speed fixed infinity corresponding reynolds number based height box girder experiments gap width tbg varied four different gap ratios ratio gap width tbg deck height corresponding test cases classified two categories cases relatively small gap ratios gap ratio cases relatively large gap ratios gap ratio addition measuring surface pressure distributions around tbg bridge deck models using array digital pressure transducers high resolution particle image velocimetry piv system utilized perform detailed flow field measurements quantify evolution unsteady vortex structures around tbg bridge deck models measurements reveal gap ratio increases vortex shedding moves trailing edge leeward box rear edge windward box simultaneously increases turbulent kinetic energy gap region fluctuating pressures leeward box vortex dimensions core core distances two neighboring vortices also affected gap ratio combining estimation pressure field measured fluctuating pressure coefficient distributions tbg models found tbg bridges larger gap ratios dramatically strengthen fluctuating pressure coefficients leeward box greatly higher small gap ratio cases moreover large gap ratio cases test model cross beams also higher fluctuating pressure coefficients leeward box decrease little comparing test model without cross beams elsevier ltd rights reserved
commentary argues recently approved contract millennium challenge corporation mcc investing million dollars niger next five years large scale irrigation good investment paper explains programme likely achieve benefits anticipated mcc commissioned detailed feasibility study carried authors paper strongly argued investing large scale irrigation part poor track record investments niger part mcc comparative advantage investments instead feasibility study presented strong case investing small scale rainwater harvesting agriculture livestock farm watershed levels individualised small scale irrigation high value nutritious crops water uses commentary concludes suggestions funds allocated large scale irrigation infrastructure million could reallocated benefit far larger number people recommendation investors african agricultural water management projects carry assessment performance impacts investment experiences past decade identify lessons could inform next decade investments agricultural water management
new voltage mode first order allpass filter using three single ended operational transconductance amplifiers otas one capacitor proposed pole frequency controlled electronically adjusting transconductance value ota moreover realizing first order allpass reposed conditions component matching required characteristics proposed filter circuit also simulated using pspice simulations verify theory
programme management remains challenging management practice northern cape department health ncdoh particularly health facility project integrate components construction management operations management order attain benefits strategic importance northern cape department health consists various administrative programmes supposed work together order attain benefits strategic importance inability integrate construction management operations management attributed poor programme management coordination within northern cape department health article reports findings case study determined programme management coordination among administrative programmes provincial office ncdoh mqcawu district office hospital underwent revitalisation could improved construction health care facility data obtained interviews personnel three sectors provincial office ncdoh district office department health hospital underwent revitalisation directly involved delivery infrastructure component project preparations operationalisation health facility completion handover results study revealed inability ncdoh integrate construction management operations management due poor programme management coordination health facility project serves means delivery health services handover furthermore research revealed among others functional silos lack skills knowledge identification critical success factors relevant integration construction operations management contributing factors poor programme management
years criminological research identified number risk factors contribute development aggressive delinquent behavior although studies identified media violence general violent video gaming particular significant predictors aggressive behavior exposure violent video games largely omitted risk factor literature delinquent behavior cross sectional study therefore investigates relationship violent video game play adolescents delinquent behavior using risk factor approach online survey completed flemish adolescents aged years old data analyzed means negative binomial regression modelling results indicated significant contribution violent video games delinquent behavior beyond multiple known risk variables peer delinquency sensation seeking prior victimization alienation moreover final model incorporated gaming genres proved significantly better model without gaming genres results provided support cumulative multiplicative risk model delinquent behavior wiley periodicals inc
bilingual education became popular chinese universities considered important aspect connotative development paper take computer programming example analyze relationship bilingual teaching english level students use real dataset including scores course two terms compare changes bilingual teaching figure effects two aspects
contact angle measurement microorganisms often described literature either investigate hydrophobic characteristic adhesion behavior cells however key aspects preparation methods differ thus difficult compare results choose procedure repetition measurements aim paper point critical points microorganism film preparation alter resulting contact angles depending moisturizing medium equilibration time contact angles differ significantly elsevier rights reserved
discovery epidermal growth factor receptor egfr activating mutations non small cell lung cancer nsclc success story egfr tyrosine kinases inhibitors tkis changed paradigm cancer therapy fromempirical cytotoxic chemotherapy tomolecular targeted cancer therapy result egfr tki therapy including gefitinib erlotinib afatinib become standard therapy nsclc patients egfr activating mutation first line therapy however patients inevitably progress despite initial dramatic rapid response egfr tkis therefore last decade lot efforts made identify overcome various resistance mechanisms fortunately secondary mutation main resistance mechanism overcome newly developed third generation egfr tkis osimertinib combination trials trying overcome resistance mechanisms mutation failed far make worse spatial temporal tumor heterogeneity clonal selection evolution also identified egfr mutant nsclc tumors nevertheless advance comprehensive sensitive molecular diagnostics monitoring technology next generation sequencing dynamic monitoring technology using circulating biomarker development new cancermedicine different mechanisms egfr tkis especially immune checkpoint inhibitors might affect change treatment paradigmof egfr mutant nsclc near future elsevier inc rights reserved
paper low complexity yet high performance recovery method coupling separable image sensing encoder proposed exploring statistical prior image representations wavelet domain specifically energy distribution natural images wavelet domain investigated found well characterized exponential decay model used statistical priori information recovery algorithm design recovery process composed two steps row wise column wise intermediates column wise row wise final results reconstructed sequentially step recovery reconstruction constrained conform statistical prior introducing weight matrix two recovery strategies different levels complexity designed named one time direct recovery otd two times iterative recovery tti otd strategy focuses extremely fast recovery speed weight matrixes two steps tti strategy weight matrix second step iteratively refined aiming achieve accurate recovery results extensive simulations conducted results show proposed recovery method otd strategy achieve much faster recovery speed traditional methods time recovery quality better recovery tti strategy achieve best recovery quality expense slight degradation recovery speed yet still faster traditional methods
introduction article result research controllers simulation investigation associated institutional project developed pontifical bolivarian university medellin colombia describes development temperature control system scaled prototype small cavity analyzes control method simulation demonstrates implement algorithm microcontroller dspic using state space representation power control per stage methodology static dynamic analysis system performed procedure described locate parameters model results presented graphically using data obtained simulation physical implementation prototype data observed behavior control system confronted changing temperature references disturbances improvements made control system enhances expected answer reaches stable state approximately minutes using controller pid open control loop conclusions second order model selected system dynamic model good precision follows approximately form experimental dynamic curve controlled system takes minutes reach stable state using pid open control loop
functional ovaries estrogen replacement therapy ert reduce risk type diabetes understanding mechanisms underlying antidiabetic effects beta estradiol may permit development molecular targeting strategy treatment metabolic disease study examines promotion insulin sensitivity weight loss treatment high fat diet hfd fed mice involve several anti adipogenic processes visceral adipose tissue magnetic resonance imaging mri revealed specific reductions visceral adipose tissue volume hfd mice compared hfd mice loss adiposity associated diminished visceral adipocyte size reductions expression lipogenic genes adipokines nuclear receptor nrc meanwhile expression levels adipose triglyceride lipase pnpla leptin receptor increased mrna levels stat transcription factor involved brown adipose tissue differentiation also increased visceral adipose expression brown adipose specific markers assessed expression immunohistochemical staining ucp increased mrna levels dio adr beta regulator ucp expression thermogenic response increased furthermore expression cpt brown adipose specific gene involved fatty acid utilization also increased methylation studies demonstrated methylation status dio adr beta significantly reduced results show improved glycemic control weight loss due involve antiadipogenic mechanisms include suppressed lipogenesis augmented fatty acid utilization addition activation brown adipose tissue specific gene expression association dependent epigenetic modifications genes
domain name system dns core internet infrastructure translates names machine readable information addresses security flaws dns led major overhaul introduction dns security dnssec extensions dnssec adds integrity authenticity dns using digital signatures dnssec however concerns suffers availability problems due packet fragmentation potent source distributed denial service attacks earlier work argued many issues dnssec stem choice rsa default signature algorithm switch alternatives based elliptic curve cryptography ecc resolve issues yet switching ecc introduces new problem ecc signature validation much slower rsa validation thus switching dnssec ecc imposes significant additional burden dns resolvers pushing load toward edges network therefore paper study question switching dnssec ecc lead problems dns resolvers handle extra load answer question developed model accurately predicts many signature validations dns resolvers perform allows calculate additional cpu load ecc imposes resolver using real world measurements four dns resolvers two open source dns implementations evaluate future scenarios dnssec universally deployed results conclusively show switching dnssec ecc signature schemes impose insurmountable load dns resolvers even worst case scenarios
recent years role epigenetic modifications pathophysiology disease received significant attention many studies beginning explore gene environment interactions may mediate early life exposure risk factors nutritional deficiencies later development behavioral problems children adults paper review current literature role epigenetics development psychopathology specific focus potential epigenetic modifications link nutrition brain development propose conceptual framework whereby epigenetic modifications dna methylation mediate link micro macro nutrient deficiency early life brain dysfunction structural aberration neurotransmitter perturbation linked development behavior problems later life
enga tradition provides ideal man learned discipline mainly initiation lived independently women realising depended women make recent decades radical transformations enga society meant considerable change men construction identity sons appear longer listen older men wonder last real men younger men today face prospect invent new ways achieve recognition men today world relying money masculine status greater social stratification succeed many affects men identity quality relationship women despite sexual emancipation changes understanding marriage gendered role expectations continue find place marriages meeting expectations may generate tensions easily lead verbal physical violence
dilute solutions diffusion dominated motion single molecules conversely non ideal concentrated solutions mass transfer diffusion heavily influenced molecular clustering cluster theory concentrated solutions approached using cussler model used explain experimental mutual diffusion data highly concentrated solutions work using cussler model critical point theory starting point new model predictions mutual diffusion coefficients binary mixtures whole composition range developed model based modifications concentration correlation function explains well experimental mutual diffusion data dependence composition activity coefficients model require knowledge intra diffusion coefficients used predict mutual diffusion coefficients whole composition range published elsevier
objective prior work shows discrimination associated wide array negative health outcomes however biological mechanisms link occurs require study evaluated association discrimination leukocyte telomere length ltl biological marker systemic aging method cross sectional data health retirement study study people aged united states included african american males females multiple regression analyses used evaluate whether discrimination independently associated ltl also considered role potential confounders including sociodemographic factors health factors depressive symptoms stress results high discrimination associated shorter ltl controlling sociodemographic factors association persisted analyses adjusted health factors depressive symptoms stress conclusion results suggest discrimination experiences accelerate biological aging older african american males females alike finding helps advance understanding discrimination generates greater disease vulnerability premature death african americans
objectives carbohydrate intolerance malabsorption suggested cause chronic abdominal pain cap subset patients aimed evaluate disaccharidase deficiencies children functional cap correlate deficiencies clinical features method patients presenting gastroenterology clinic children hospital wisconsin abdominal pain prospectively completed detailed demographic history symptom questionnaire cap cohort included least month symptoms data disaccharidase activity histology endoscopic biopsies collected retrospectively patients normal histology included study association groups low disaccharidases clinical features examined results total pediatric patients cap included mean age years male percentages abnormally low disaccharidase levels using standard laboratory cutoffs lactase sucrase glucoamylase palatinase thirty nine percent patients low lactase also low sucrase patients low sucrase low lactase significant difference activities disaccharidases sucrase lactase ratio relation age also association found stool consistency stool frequency location pain low disaccharidase activity conclusions large proportion patients cap deficiencies disaccharidases bowel frequency vomiting location pain different groups suggesting clinical features used predict disaccharidase deficiencies
report summarizes year activities within department energy metal hydride center excellence mhcoe purpose mhcoe conduct highly collaborative multi disciplinary applied develop new reversible hydrogen storage materials light duty vehicles mhcoe combined three broad areas mechanisms modeling provided theoretically driven basis pursuing new materials materials development new materials synthesized characterized system design materials engineering provided foundational information enable new materials realized practical automotive hydrogen storage systems mhcoe organized four materials oriented projects along one engineering project results projects given well account downselection process identified materials pursued initial investigation downselected materials compared material goals derived revised doe hydrogen storage system targets light duty vehicles suggestions recommendations directions given based mhcoe findings copyright hydrogen energy publications llc published elsevier ltd rights reserved
simple experimental setup measuring planck constant using landauer quantization conductance touching gold wires described consists two gold wires thickness length operational amplifier setup costs less realized every teaching laboratory two weeks use oscilloscope required
background hiv hcv infection common manipur increase number intravenous drug users idus eastern border state india hiv hcv patients die liver complications spite highly active antiretroviral therapy haart aim present study compare clinico immunological response highly active antiretroviral therapy hiv hiv hcv infection manipur materials methods present study conducted hiv mono infected group hiv hcv infected group patients first line antiretroviral treatment art results present study clinico immunological response art groups recorded commonest route transmission heterosexual activity followed idus trend almost coinciding initial cells mean hiv group higher month month month cells art compared hiv hcv group significantly response better hiv hcv treatment hiv hcv without hcv treatment conclusion present study showed immunological response art hiv hiv hcv infection groups good better hiv group amongst hiv hcv infection immunological response better undergone hcv treatment routine screening hcv hiv infected patients starting hcv treatment early result better quality life
evaluate means longitudinal study radiographic involvement metacarpophalangeal radio carpal joints hand osteoarthritis relationship erosive disease progression patients hand osteoarthritis enrolled patients underwent hand rays basis presence central erosions interphalangeal joints patients divided three groups central erosions one joint central erosion two joints central erosions longitudinal study patients nine normal controls whose rays available years performed radiological involvement metacarpophalangeal radio carpal joints evaluated using kellgren lawrence oarsi scores low number joints showed kellgren lawrence values group group group low score values obtained radiographic items metacarpophalangeal joint space narrowing score showed significant increase groups subsequent adjustment age gender bmi confirm statistical significance marginal erosions rarely found joints metacarpophalangeal radio carpal radiographic per patient scores significantly worsened follow significant increase joints kellgren lawrence score found normal controls significant radiographic worsening found minority metacarpophalangeal joints shows kellgren lawrence value metacarpophalangeal lesser extent radiocarpal joints significant worsening follow metacarpophalangeal joint involvement hand osteoarthritis mild progressive radiocarpal involvement negligible
obesity chronic kidney disease ckd public health priorities share core pathophysiological mechanisms however whether high body mass index bmi increases risk ckd novo remains ill defined evaluate role bmi predicting ckd onset general adult population performed systematic review meta analysis pubmed isi web science databases articles published january august without language restriction selected studies adult individuals general population normal renal function baseline reported risk low estimated glomerular filtration egfr min albuminuria dipstick albumin creatinine ratio mmol hazard ratio odds ratio relative risk related obesity overweight bmi continuous value total cohorts covering participants mean follow years selected obesity increased relative risk confidence interval heterogeneity developing low egfr albuminuria increase bmi unit also associated higher risk low egfr albuminuria conversely overweight predict onset either low egfr albuminuria thus high bmi predicts onset albuminuria without kidney failure ckd stages well ckd stages higher effect significant obese individuals hence findings may implications improve risk stratification recommendations body weight control general population
rotation symmetric boolean functions extensively studied recent years applications cryptography study novel method construct variable resilient rotation symmetric functions proposed based latin square maximum cycle structure required solve equation system lower bound number variable resilient rotation symmetric functions given last equivalent characterization variable resilient rotation symmetric functions demonstrated direct corollary number variable resilient rotation symmetric functions represented solutions equation system john wiley sons ltd
three methods operational amplifier amp slew rate verification considered methods illustrated example spice macro models amp lmh texas instruments analog devices
paper show extended tanh method zhang applied construct exact breather type solutions nonlinear evolution equations solutions might used rogue wave prototypes illustrative examples present exact solutions boiti leon pempinelli equation dimensional breaking soliton equation respectively solution waves include rational rogue waves non rational rogue waves published elsevier ltd
objectivein article describe pragmatic framework supporting supervision based contextual behavioural perspective methodthe development psychological skills competent level requires didactic experiential learning supervision agreed central vehicle integration experiences alongside engaging problem solving giving instructions build adherence supervisors reasonably expect supervisees learn experience attending closely influences effects choices experiential learning help psychologist develop sensitivity applying knowledge skills effective safe ways clients thus demonstrating competence resultswe argue contingency shaped learning strengthened including supervision elements promote psychological flexibility capacity actively embrace one private experiences present moment engage disengage patterns behaviour service chosen values psychological flexibility found foster wellbeing work effectiveness openness new learning compassion acceptance difference diversity workplace settings moreover psychological flexibility psychologists found predict use evidence based interventions exposure conclusionthe shape framework identifies five features supervision values hold stories lightly assessment function perspective taking experiential methods likely promote psychologists psychological flexibility experiential learning supervision context five features extensions agreed supervision best practices enhanced developments contextual behavioural science perspective taking cognitive defusion acceptance describe examples using shape present research directions assess whether features promote experiential learning supervision
present research work planned investigate biochemical parameters tuberculosis patients comparison healthy individual patients infected hepatitis virus hcv study determined liver enzymes serum proteins hemoglobin photometrically erythrocyte sedimentation rate esr westergren method results showed significant increase level aspartate aminotransferase observed test group non significantly reduced level observed control group compared healthy controls alkaline phosphatase increased significantly control group compared healthy control group significant variation concentration serum proteins among different groups studied population also observed significant variation serum calcium level observed among study groups esr found lower healthy control group significantly increased test control groups hcv infected patients investigated hcv screening immunochromatographic method concluded variation biochemical hematological parameters observed studied population help diagnose hcv infected patients
important prerequisite prospective competitive factories enduring development production related competencies today universities manufacturing engineering learning factories action oriented approach developing competencies highly authentic learning environments genuine products manufactured simulated life like production setting study aims investigating learning success engineering students learning factory results conducted experiment presented discussed giving proof hypotheses students learning factory results conducted experiment presented discussed giving proof hypotheses students greater application performance higher degree action substantiating knowledge attended action oriented learning event within learning factory receiving conventional treatment published elsevier ltd selection peer review responsibility association science education technology
test information theory prosocial behavior whereby ego utility self signaling crowd effect consumption utility choice data come two field experiments involving purchases consumer good bundled charitable donation across experimental cells randomize price level donation level model free analysis data reveals nonmonotonic regions demand good bundled relatively large charitable donations subjects also self report lower ratings feeling good offered bundles large donations price discounts evidence suggests price discounts crowd consumer self inference altruism alternative motivation crowding theories rejected due inability explain nonmonotonic data moments standard use interaction effects falsification checks explore underlying choice mechanism experimental setting complicated self signaling context instead novel feature analysis consists using experimental data estimate structural form model consumer demand self signaling specify model consumers obtain consumption ego utility choices ego utility derives consumer posterior self beliefs making choice estimator proposed handles potential multiplicity equilibria arise self signaling model model estimates allowus quantify economic role ego utility explore underlying signaling mechanism nested tests reject hypothesis self signaling alternative model specifications potentially allow nonmontonic demand without self signaling structure exhibit inferior fit data model estimates imply consumer response donations mainly driven ego utility consumption utility altruistic motives findings combination field experiment structural model contribute growing literature self signaling consumer behavior quantifying magnitude self signaling preferences choices results also implications design cause marketing campaign potential negative synergies price nonprice promotions
background multicentre trials investigating food allergies double blind placebo controlled food challenges dbpcfc need standardized procedures challenge meals evaluation criteria aimed developing standardized approach identifying patients birch related soy allergy means dbpcfc soy including determination threshold levels multicentre setting methods microbiologically stable soy challenge meals composed protein isolate consistent gly levels patients sensitized main birch allergen bet concomitant sensitization soy homologue gly underwent dbpcfc outcome defined according presence absence ten objective signs intensity eight subjective symptoms measured visual analogue scale vas results adult subjects female mean age years underwent dbpcfc challenge meals defined evaluation criteria showed good applicability centres involved presented objective signs subjective symptoms soy challenge placebo challenge meals elicited non cardiovascular objective signs subjects dbpcfc judged positive dpbcfc showed objective signs subjective symptoms soy challenge subjective symptoms soy challenge meal dbpcfc subjects started significantly lower dose levels objective signs median cumulative eliciting doses first objective signs dbpcfc subjects total soy protein first subjective symptoms conclusions present hitherto largest group adults bet gly sensitization investigated dbpcfc type food allergy evaluation dbpcfc outcome include monitoring objective signs also scoring subjective symptoms data may contribute standardize dbpcfc pollen related food allergy multicentre settings
background candida species primary cause invasive fungal infection hospitalized children data risk factors postoperative candidemia pediatric patients congenital heart defects study aimed identify risk factors candidemia patients congenital heart defects underwent cardiac surgery methods case control study conducted patients admitted pediatric cardiology intensive care unit january december candidemia cases matched control patients without candidemia multivariate analyses conducted determine predictive probabilities incidence candidemia risk higher results thirty patients diagnosed candidemia incidence cases patient days matched controls risk factors independently associated candidemia included risk adjustment congenital heart surgery rachs category odds ratio confidence interval use acid suppression therapy confidence interval thrombocytopenia confidence interval predictive probabilities ranged rachs category combined rachs thrombocytopenia acid suppression therapy use case fatality rate within days candidemia conclusion first report using rachs category risk factor invasive candidiasis patients congenital heart defects pediatric intensive care unit studies must conducted validate risk factors candidemia pediatric population
study investigated effect carbon fibers brush anode materials performance microbial fuel cells mfcs two types carbon fibers different electrical resistivity functionality polyacrylonitrile pan rho omega pitch rho omega investigated ray photoelectron spectroscopy analysis showed pan pitch based carbon fibers presented almost surface elements functional groups significant difference microbial growth brush anodes current interrupt steady discharging methods demonstrated pitch based carbon brush anodes lower ohmic resistance generated higher power density nitric acid treatment power density generated pan pitch based anodes increased achieving respectively using pitch based carbon fiber brush anode attained better performance widely used pan based carbon brush acid treated pitch based carbon fibers provide promising alternative highly efficient anode materials extensive application mfcs elsevier rights reserved
investigate electrical characteristics according changing temperature trap distribution energy gap grain boundary interface trap density polycrystalline silicon poly channel tunnel oxide vertical nand vnand flash cell poly channel confirmed two factors changing potential barrier height trap distribution dit using technology computer aided design tcad simulation also found electrical characteristics according changing temperature significantly dependent height position potential barrier vnand flash cell poly channel expect required develop accurate extraction method trap distribution dit better understanding temperature dependence electrical characteristics vnand flash cell
kidd castano press critique failure replicate kidd castano grounds failure exclude people read texts failure random assignment failure exclude people take author recognition test art response addresses critiques importantly note even kidd castano reanalyzed data way argue appropriate still failed replicate pattern results reported original study thus reaffirm replication kidd castano found evidence literary fiction uniquely immediately improves theory mind objective remains prove reading literary fiction benefit social cognition call depth research addressing difficulties measuring potential effect note need temper claims accordingly document copyrighted american psychological association one allied publishers article intended solely personal use individual user disseminated broadly
years since first digital imaging sensor invented last four decades image acquisition functionality continuously improved terms quality size cost consequently digital imaging techniques started utilized digital camera industry various component applications well according trend current applications digital imaging images produced conventional mechanism regular camera also applications digital image acquisition functionality aim better understand circumstances using analysis images consequence trend amount images created diverse image related devices immeasurably huge moreover utilization voluminous amount images demands management system support information management operations search contents duplication modification detection operations efficiently effectively processed image related operations performed usage distinctive values image processing operations require much processing time order meet satisfaction requirement studied approaches utilize line segments luminance areas however approaches disadvantage case image contains relatively large regions sparse edges stationary luminance order resolve circumstances paper present improved approach perspective cost requirement satisfaction proposed method mainly exploits luminance areas pixel location produced image identifiers could satisfy one one relationship images identifiers experimental evaluations demonstrate approach favorable considering cost effectiveness efficiency
objective present study compare group mediated cognitive behavioral gmcb physical activity intervention traditional exercise therapy trad upon select social cognitive outcomes sedentary knee osteoarthritis knee patients total patients mean age years women recruited using clinic community based strategies month single blind two arm randomized controlled trial mobility related self efficacy self regulatory self efficacy srse satisfaction physical function spf assessed baseline months results intent treat treatment gmcb trad time month analyses covariance yielded significantly greater increases srse spf relative trad partial correlations revealed changes srse spf significantly related improvements physical activity mobility months gmcb intervention yielded favorable effects important social cognitive outcomes trad effects related improvements physical activity mobility
anxiety depression highly prevalent adolescence characterized negative attentional bias attentional bias modification abm reduce bias might also affect emotional reactivity could promising early intervention however growing number studies also report comparable improvements active placebo groups current study investigated effects eight online sessions visual search abm compared placebo training training control group adolescents heightened symptoms anxiety depression attention bias interpretation bias stress reactivity assessed pre post training primary outcomes anxiety depressive symptoms secondary measures emotional resilience assessed pre post training three six months follow results revealed training reduced attentional bias compared control groups stronger effects participants completed training sessions irrespective training condition overall reduction symptoms anxiety depression increase emotional resilience observed six months later training evaluated relatively negatively results suggest online abm employed current study added value early intervention adolescents heightened symptoms authors published elsevier ltd
idea internal initiation frequently exploited explain peculiar translation properties unusual features eukaryotic mrnas review summarize methods arguments commonly used address cases translation governed internal ribosome entry sites iress frequent mistakes revealed explain cap independent readily mean ires dependent presence long highly structured untranslated region utr translation stress conditions regarded argument appealing internal initiation carefully describe known pitfalls limitations bicistronic assay artefacts commercially available vitro translation systems explain plasmid dna transfection used ires studies control experiments unavoidable someone decides use anyway finally propose workflow validation ires activity including fast simple experiments based single genetic construct sequence interest
paper use two host one pathogen immuno epidemiological model argue principle host evolution host subjected fatal disease minimization case fatality proportion principle valid whether disease chronic leads recovery case continuum hosts stratified immune response stimulation rate suggest minimum trade exists virulence host induced pathogen virulence induced immune response find minimization case fatality proportion evolutionary stable strategy host
autism spectrum disorders asd neuropsychiatric disorders characterized impairment social interactions verbal nonverbal communication restricted stereotyped patterns interest behavior within first years life pharmacologic interventions may needed treatment temper tantrums aggression hyperactivity stereotypes children asd approval aripiprazole united states food drug administration usfda treatment temper tantrums children adolescents asd gained increased interest use patients aripiprazole partial agonist dopamine serotonin hta receptors antagonist hta receptors aripiprazole partial agonist speculated aripiprazole protective effect extrapyramidal side effects movement disorders metabolic problems increased use children adolescents associated increase number case reports related problems nevertheless review literature uncovered limited data regarding association acute dystonia aripiprazole use asd children five years age paper present two cases autistic spectrum disorder children ages years developed acute dystonia taking aripiprazole
english language proficiency english language development elp standards guide content specific instruction assessment practiced teachers english learners els varying levels english proficiency perform grade level specific academic standards schools transition state developed indiana elp standards adopted world class instructional design assessment wida english language development standards adopted paper explores indiana elp standard year history district bilingual district leaders interpreted implemented two sets standards school years using critical leadership feminism within narrative design bilingual leaders illuminate distinct leadership logics mediate implement elp standards districts academic content standards regarded greater privilege complicating bilingual leaders position elp standards restricted standards hierarchy bilingual leaders found limited educational venues discuss performance based nature elp standards implications assessment policy leadership preparation discussed
paper presents design test results eight channel prototype integrated circuit chip intended greatly simplify pulse processing electronics needed large arrays scintillation detectors chip design employs user controlled multi region charge integration particle identification incorporated basic design channel chip also contains time voltage converter provides relative time information puise height integrals relative time stored capacitors either reset user controlled time sequentially read acquisition event desired three pulse height sub channels consists gated integrator eight programmable charging rates externally programmable gate generator defines start four time ranges width four time ranges gate relative external discriminator signal chip supports three triggering modes two time ranges two power modes produces four sparsified analog pulse trains three integrators another time synchronized addresses chip digitization pipelined adc eight channel prototype chip occupies area dissipates low power mode fabricated ami process elsevier rights reserved
gastro intestinal peptide ghrelin assigned many functions include appetite regulation energy metabolism glucose homeostasis intestinal motility anxiety memory neuroprotection last decade pleiotropic peptide proposed therapeutic agent gastroparesis diabetes cachexia cancer ghrelin receptor expressed throughout brain play important role motivation reward ghrelin finely modulates mesencephalic dopaminergic signaling thus currently studied pathological conditions including dopamine related disorders dopamine regulates motivated behaviors modulating reward processes emotions motor functions enable survival individuals species numerous dopamine related disorders including parkinson disease eating disorders like anorexia nervosa involve altered ghrelin levels however despite growing interest ghrelin pathological conditions global integrative studies investigating role brain dopaminergic structures still lacking review discuss role ghrelin dopaminergic neurons relevance search new therapeutics parkinson disease anorexia nervosa related dopamine deficits elsevier ltd rights reserved
indoor space visual reconstruction many applications done accurately enables people conduct different indoor activities efficient manner example effective efficient emergency rescue response accomplished fire disaster situation using visual information destroyed building therefore accurate indoor space visual reconstruction system operated given environment without gps developed using human operated mobile cart equipped laser scanner ccd camera omnidirectional camera computer using system accurate indoor visual data reconstructed automatically obtained data used rescue operations guiding blind partially sighted persons forth
paper two axis compensation device designed eliminate impact attitude deviations moving platform laser point cloud order improve dynamic performance compensation device fuzzy proportional integral differential pid controller employed compensation device semi physical simulation experiment carried quantitatively evaluate dynamic performance compensation device using three axis turntable high accuracy inertial measurement unit imu used measure attitude deviations three axis turntable real time result roll pitch deviations turntable measured imu compensated using two orthogonal frameworks compensation device controlled fuzzy pid controller experimental results showed fuzzy pid controller compensated attitude deviations accurately traditional pid controller laser pointing direction could remained within degrees using compensation device
multimode resource constrained mrc problem aims finding start times execution modes activities project minimizes project duration current precedence constraints resource limitations study integrates fuzzy means clustering technique chaotic technique differential evolution develop fuzzy clustering chaotic based differential evolution fcde algorithm efficient hybrid approach solving mrc related problems within fcde chaos prevents optimization algorithm premature convergence fuzzy means clustering acts several multi parent crossover operators utilizing population information efficiently enhance convergence efficiency study applies serial method reflect individual user priorities active schedule project duration calculations experiments run indicate proposed fcde mrc obtains optimal results reliably efficiently benchmark algorithms considered fcde mrc promising alternative methodology handling resource constrained problems
quality family functioning considered important predictor adaptation children chronic conditions parents previous research suggests beyond general family functioning specific experience family condition management paramount understanding family members adaptation study first goal compare family functioning parents children adaptation outcomes across four chronic conditions asthma diabetes epilepsy obesity secondly explored mediating role family life difficulties parental mutuality two potential paths family cohesion linked family members adaptation total parents children years old asthma obesity epilepsy diabetes completed self report measures family cohesion family life difficulty parental mutuality anxiety depressive symptoms children health related quality life hrqol results showed families children diabetes obesity epilepsy higher risk experiencing family difficulties children deteriorated hrqol compared families children asthma regard links among study variables although family cohesion direct indirect relationship parental depressive symptoms links parental anxiety symptoms children hrqol indirect family life difficulty associations consistent across four clinical groups findings emphasize relevance family centered interventions aimed promoting family cohesion parents mutuality effective coping demands pediatric chronic conditions
introduction modern imaging may aid diagnosis prognosis monitoring therapeutic response psoriatic arthritis psa detection osteitis technical advances like whole body magnetic resonance imaging mri exemplify value technology areas covered ultrasound provides clinic based tool evaluating joint pathologies extra articular structures especially enthesitis including skin nail disease recent studies demonstrated subclinical disease psoriasis without arthritis well psa implications diagnosis treatment classification modern imaging also facilitate decisions tapering expensive biologics though real world clinical studies still lacking expert commentary increase novel psa therapies increase utilization modern imaging providing increased validation imaging biomarkers well responsive outcome measures
etiology crohn disease still unknown although new theories based defects innate immunity previously shown decrease gamma delta cells patients previous studies shown high prevalence anti simplex immunoglobulins patients diminution gamma delta cells peripheral blood intestinal mucosa patients may create state immunosuppression would facilitate simplex infection study antibody responses anisakis antigens crohn disease patients relationship alpha beta gamma delta cell subsets recruited patients healthy controls alpha beta gamma delta cell subsets anti simplex antibodies measured levels anti simplex igg igm significantly increased patients almost patients positive igg igm anti simplex versus respectively normal subjects however lower specific iga levels observed group patients versus healthy subjects found association gamma delta subset igm anti simplex levels ileal cases stricturing behavior observed highest levels specific antibodies exception anti simplex iga relationship specific antibodies gamma delta cell deficiency makes cell candidates play role immune response anisakis addition anti anisakis antibodies could considered markers risk progression
certain drugs nitroaromatic compounds potentially toxic practical importance assess predict mutagenic potency process drug discovery classical quantitative structure activity relationship qsar model developed using linear partial least square pls scheme understand underline mutagenic mechanism non classical qsar model derived using machine learning based hierarchical support vector regression hsvr predict mutagenicity nitroaromatic compounds based series mutagenicity data observed hsvr performed better pls manifested predictions samples training set test set outlier set well various statistical validations mock test designated mimic real challenges also confirmed better performance hsvr furthermore hsvr exhibited superiority predictivity generalization capabilities consistent performance robustness compared various published predictive models pls conversely revealed mechanistically interpretable relationships descriptors mutagenicity thus two qsar approach using predictive hsvr interpretable pis models synergistic fashion adopted facilitate drug discovery development designing safer drug candidates nitroaromatic moiety elsevier ltd rights reserved
background purpose work determine parameters assessed cardiopulmonary exercise testing cpet using supplemental oxygen independently predict one year transplant free survival patients interstitial lung disease ild referred lung transplant evaluation methods performed chart review patients ild completed cpet fio gathered spirometry pulmonary hemodynamic six minute walk cpet data primary end point death lung transplantation within one year cpet results final data set included patients patients died underwent transplant survived transplant free multivariable cox regression revealed peak workload predicted nadir cpet spo fvc predicted independent predictors one year transplant free survival independent predictors survival receiver operating characteristics analysis revealed peak workload predicted cutoff highly discriminatory nadir cpet spo fvc predicted identifying patients risk one year mortality transplant peak workload predicted area curve auc nadir cpet spo auc fvc predicted auc conclusion peak workload predicted nadir cpet spo fvc predicted ild patients referred lung transplant evaluation independently predictive one year mortality need transplant elsevier ltd rights reserved
among population known galactic black hole ray binaries grs stands multiple ways continuous outburst since shown wide range different states distinguished timing spectral properties states also observed igr past linked accretion dynamics present first comprehensive study long term evolution grs using entire data set observed rossi ray timing explorer lifetime develop set descriptive features allowing automatic separation states show supervised machine learning form logistic regression random forests used efficiently classify entire data set first time explore duty cycle time evolution states entire time span find temporal distribution states likely changed span observations connect machine classification physical interpretations phenomenology terms chaotic stochastic processes
blastocystis common intestinal parasitic protist infecting birds mammals blastocystis comprises least subtypes detected humans significant correlation certain subtypes pathogenicity remains established nevertheless studies suggest potential linkage subtypes inter intra subtype variation clinical manifestations aim study identify intra subtype genetic variation subtypes blastocystis stools samples submitted diarrheic non diarrheic patients fragment nuclear small subunit ribosomal rrna gene amplified culture positive samples isolated diarrheic non diarrheic iranian patients pcr products sequenced sequences subjected phylogenetic analysis intra inter subtype variation calculated based comparison reference sequences genbank found samples respectively diarrheic stools observed eight nine patients respectively statistically significant correlation found subtypes diarrhea multiple sequence alignment exhibited within subtype similarity respectively highest similarity seen among isolates lowest similarity seen among isolates phylogenetic analysis suggest correlation diarrhea intra subtype variation inter intra subtype variation ssu rrna gene appears reflect differences clinical outcome blastocystis carriage elsevier rights reserved
female hormones play significant role etiology treatment many women health conditions article focuses common uses hormonal therapy prescribing estrogen containing regimens throughout span woman life risks similar cardiovascular risk venous thromboembolism degree risk varies significantly depending woman particular set risk factors details hormone regimen addition estrogens progestogens article also touches use selective steroid receptor modulators emergency contraception treatment menopause symptoms
simplified method plane buckling analysis pylons multi span suspension bridges proposed analysis model pylon equivalent spring connected saddle stiffness equivalent spring derived relation horizontal displacement saddle restoring forces cables expressed simple formula stiffness deck considered also simplified method method suitable three pylon suspension bridges also suspension bridge multiple pylons example taizhou bridge two span length three pylons indicates equivalent spring stiffness different load case significant large span suspension bridge equivalent spring stiffness mid pylon small comparing side pylons buckling problem mid pylons important side pylons continuous suspension bridge multiple pylons
aimthe aim study explore factors affecting adaptation role motherhood mothers preterm infants admitted neonatal intensive care unit backgroundtransition motherhood often causes significant issues terms adaptation role motherhood main factors leading parental stress especially neonatal intensive care unit shown greatest source stress loss women role mothers designit qualitative study content analysis approach methodssemi structured depth interviews used data collection interviews conducted mothers preterm infants weeks hospitalized least one week neonatal intensive care unit purposive sampling maximum diversity used recruit mothers kermanshah province west iran data collected interviews recorded transcribed verbatim data analysed using conventional content analysis findingsexplanation mothers perspective towards factors affecting adaptation role motherhood led two main categories individual factors emotional distress self efficacy interaction alienation social factors support prejudice conclusionadaptation role motherhood promoted supporting mothers preterm infants empowering increasing self efficacy eliminate negative factors emotions
purpose reviewageing accompanied reduction circulating testosterone progressive accumulation medical morbidities intense debate whether low testosterone contributes ill health opposed biomarker presence prescriptions testosterone rising background concern potential adverse effects review examines evidence relating androgens cardiovascular risk older men recent findingsobservational studies show lower risk cardiovascular events older men higher testosterone lower mortality ischaemic heart disease men higher concentrations potent androgenic metabolite dihydrotestosterone however randomized controlled trials testosterone supplementation underpowered outcome cardiovascular events recent meta analyses reached contrasting conclusions regarding cardiovascular adverse events associated testosterone therapy retrospective studies prescription databases produced controversial conflicting results summaryadditional randomized controlled trials required clarify role testosterone supplementation older men absence pituitary gonadal disease pending studies testosterone therapy considered androgen deficient men evaluation potential benefits risks
economic environmental policies strategies largely designed international national regional level environmental impacts measures often felt geographically localized level particular effects water resources especially regarding water pollution water stress usually localized specific hotspots work acknowledge facts attempt identify linkages among regions spain semi arid country significant geographical variations water availability european union rest world also looking local effects interactions particular study grey water footprints measure assimilation capacity water resources production regional business level spatially explicit information extension footprints throughout supply chain also computing water footprints consumption regional level process combination detailed computation grey water footprints production agriculture diffuse pollution general economic activities point source pollution multiregional input output model encompasses spanish regions also identify hotspots vulnerable areas linking grey water footprints production originating areas final consumer responsibilities example potential combined methodology design evaluate effects grey water footprints scenarios import substitutions spain results show strong final demand regions madrid catalonia net exporting regions andalusia aragon castile leon castile mancha extremadura navarre regions contain areas clearly vulnerable nitrates pollutants parts regions obviously andalusia extremadura suffer water stress leads question sustainability relationships structure production trade environment elsevier ltd rights reserved
objective clinical data available new computer aided design computer assisted manufacture cad cam material zirconia reinforced lithium silicate zls ceramic study describes preliminary clinical results indirect zls cad cam restorations months method materials indirect restorations fabricated using cerec method intraoral scanning cerec omnicam cerec mcxl sixty seven restorations seated adhesively baseline sixty restorations evaluated months follow using modified fdi criteria two groups established according zls restorations post processing procedure prior adhesive seating group three step polishing group fire glazing statistical ana lysis performed mann whitney test wilcoxon test statistically significant differences found criteria surface gloss group group mann whitney test conclusion study demonstrates zls cad cam restorations high clinical success rate months longer clinical evaluation period necessary draw conclusions
double diffusive flow cavity attracted lots attention due importance many engineering fields ocean circulation crystal growth pollution transportation air metal manufacturing process heat mass transfer occur simultaneously double diffusive flow fluid flow driven temperature gradient also concentration gradient well cases dufour soret effects play significant role double diffusive flow process energy flux created concentration gradient called dufour effect temperature gradient cause mass flux soret effect taking soret dufour effects account temperature concentration equations become coupled however coupling diffusivities matrix diagonalized coupled system transformed two uncoupled diffusion advection equations two independent species temperature concentration obtained inverse transformation two independent species numerical method developed past two decades lattice boltzmann method lbm powerful simulating complex heat transfer fluid mechanics problems current study lattice boltzmann model developed implemented double diffusive convection soret dufour effects three distribution functions used compute fluid velocity specie specie respectively specifically rectangular enclosure horizontal temperature concentration gradients investigated hand graphics processing units gpu computing becomes popular since advent nvidia cuda platform includes hardware components software programming environment developed lbm code adapted cuda platform accelerate computation parametric studies gpu responsible parallel tasks cpu tackles sequential steps computation verify improvement computation ability using gpu ratio computational time cpu code cuda code presented simulating classical natural convection process cavity computational speed accelerated times large number nodes used fluid flow temperature field concentration field presented different rayleigh numbers buoyancy ratios prandtl numbers lewis numbers aspect ratios well soret dufour coefficients addition results nusselt sherwood numbers shown different parametric conditions result lattice boltzmann method demonstrated good option study complex double diffusive convection soret dufour effects vertical cavity elsevier ltd rights reserved
problem axial dynamic pile soil interaction analytical representation using concept dynamic winkler support revisited shown depth frequency dependent winkler springs dashpots obtained dividing complex valued side friction corresponding displacements along pile may faithfully describe interaction effect contrary common perception winkler concept always approximate axisymmetric wave solution based linear elastodynamic theory derived harmonic steady state response finite infinitely long piles homogeneous viscoelastic soil stratum former type pile resting rigid rock pile modelled continuum without restrictions associated strength materials approximations closed form solutions obtained displacement field soil pile stiffness damping impedance coefficients pile head actual depth dependent dynamic winkler moduli set fictitious depth independent winkler moduli match dynamic response pile head results presented terms dimensionless graphs tables simple equations provide insight complex physics problem predictions model compare favourably existing solutions new results simple design oriented formulae presented
paper describes experiences obtained construction high soil reinforced retaining wall walls used foundation large logistic distribution centres inclined terrain first problems appeared roughly years wall construction wide tensile cracks fill surface observed behind zone reinforcement first step problem evaluation showed crack connected wall overturning therefore reconstruction recommended upper part removed constructed new evaluation relevant limit states design situations phase reconstruction monitored used approval safe design experiences obtained described phases create important know next similar applications
atrial fibrillation heart failure diseases often coexist aggravating prognosis constituting major public health problem aim study assess prevalence atrial fibrillation patients chronic heart failure determine clinical profile group patients conducted retrospective descriptive study based registry heart failure department cardiology university hospital centre june march patients years age chronic heart failure associated atrial fibrillation included study study period patients chronic heart failure associated atrial fibrillation enrolled prevalence heart failure frequency cardiovascular risk factors associated hypertension diabetes dyslipidemia tobacco sedentary lifestyle menopause affected men women causes chronic heart failure associated atrial fibrillation heart valve diseases coronary artery diseases hypertensive primary toxic chronic alcoholism atrial fibrillation frequently appears patients heart failure morocco occurs average age lower found literature
computing centroidal voronoi tessellations cvt many applications computer graphics existing methods lloyd algorithm quasi newton solver efficient easy implement however compute local optimal solutions due highly non linear nature cvt energy paper presents novel method called manifold differential evolution mde computing globally optimal geodesic cvt energy triangle meshes formulating mutation operator using discrete geodesics mde naturally extends powerful differential evolution framework euclidean spaces manifold domains mild assumptions show mde provable probabilistic convergence global optimum experiments wide range models show mde consistently outperforms existing methods producing results lower energy thanks intrinsic global nature mde insensitive initialization mesh tessellation moreover able handle multiply connected voronoi cells challenging existing geodesic cvt methods
node innervation right vagus nerve introductionradiofrequency isolation pulmonary vein accompanied transient sinus bradycardia atrioventricular nodal avn block suggesting influence vagal cardiac innervation however importance atrial fat pads relation vagal innervation avn humans remains largely unknown aim study evaluate role ganglionated plexi innervation avn right vagus nerve methods resultsdirect epicardial high frequency stimulation hfs patients right vagus nerve patients performed fat pad exclusion destruction patients undergoing thoracoscopic epicardial ablation treatment persistent asystole longer seconds acute prolongation considered positive response hfs prior ablation positive responses hfs detected gps patients gps patients one patients exclusion fat pads patients negative response hfs patients exhibited positive response right vagus nerve stimulation demonstrated negative responses ablation conclusionthe integrity essential right vagus nerve exert physiological effects avn humans
study examines whether perception peripersonal action space interpersonal social space modified patients restrictive type anorexia two experimental conditions using videos first participants stopped video approaching stimulus felt distance comfortable interacting first person perspective second participants stopped video observed individual approaching stimulus approached comfortable distance third person perspective first person perspective results showed estimation peripersonal space differ controls object approaching increase interpersonal space compared controls male female individual approaching third person perspective individual object individual individual distances larger anorexic patients results indicate specific deficit adjusting interpersonal distances first person third person perspectives copyright john wiley sons ltd eating disorders association
introduction growing evidence suggests multiple factors insulin resistance nutritional factors gut microbiota hormones released adipose tissue act together genetically predisposed individuals aimed investigate whether various single nucleotide polymorphisms snps play role development nonalcoholic fatty liver disease nafld severity liver damage anatolian population methods two hundred sixteen patients biopsy proven nafld control participants aged years consecutively enrolled multicenter study blood samples genotyped pnpla ilb ppar ala ppar pro ala sod lox ivs polymorphisms using custom made lightsnip assays lightcycler instrument results genotypic distributions pnpla snps different nafld control participants snps pnpla polymorphism associated fold increased risk development nafld odds ratio confidence interval patients pnpla genotype higher nonalcoholic fatty liver disease activity score levels compared patients pnpla genotype nafld patients without fibrosis higher frequency ilb genotypes compared nafld patients fibrosis conclusion present study proposes polymorphisms pnpla gene highly predictive value development nafld independently associated severity liver histology patients nafld results study suggest ilb may play important protective role development advanced fibrosis even cirrhosis copyright wolters kluwer health inc rights reserved
methodology developed selection gear number transmission gear ratios mechanical part wheel type tractor electro mechanical transmission containing propulsion asynchronous electric motor variable frequency control paper proposes determine transmission gear ratio basis following provision wheel torque dependence tractor speed best one traction process transfer one gear provision nominal operational mode electric motor tractor operations working long period time provision minimum possible number gears complete realization internal combustion engine power tractor wheels limit operational mode electric motor characteristic asynchronous electric motor variable frequency control contains various portions used either completely partially due operating conditions gear number determined process transmission gear ration finding prior wheel torque tractor electro mechanical transmission limited according following factors grip wheel supporting surface maximum power internal combustion engine transferred wheels torque developed propulsion electric motor proposed exceed nominal operational mode propulsion electric motor operations tractor working long period time case significant excess nominal operational mode asynchronous electric motor rather long operation leads low efficiency high losses power large heat liberation consequently requires develop complicated system electric motor cooling excess nominal electric motor torque justified short term operational modes case need select powerful electric motor create additional gear gear box
introduction hypothesisthe validity reliability measurement urinary ngf diagnostic biomarker women lower urinary tract dysfunction lutd uncertain aimed evaluate diagnostic discriminant validity test retest reliability urinary ngf measurement women lutd methodsurinary ngf measured women lutd asymptomatic subjects urinary ngf assayed using elisa method normalized urinary creatinine ngf creatinine ratios compared symptom subgroups using mann whitney test different urodynamic diagnoses using kruskal wallis test receiver operator characteristic roc analysis employed evaluate diagnostic performance urinary ngf test retest reliability ngf measurement assessed using intra class correlation icc resultsurinary ngf significantly non specifically increased symptomatic patients compared controls ngf multivariate logistic regression ngf good predictor patients oab however adjusted odds ratio roc analysis demonstrated poor discriminant ability different symptomatic groups urodynamic groups using cut ngf creatinine test provides sensitivity specificity overactive bladder assays demonstrated good test retest reliability icc conclusionsalthough urinary ngf reliably assayed increased various lutds discriminates poorly disorders therefore limited potential biomarker neurourol urodynam wiley periodicals inc
insofar urban school systems often identified ineffective include large segment students vital improve academic success provide context article first discusses key challenges facing urban schools second article identifies briefly reviews variety approaches reform models often employed efforts improve student learning urban schools third article briefly discusses importance principal leadership relation school success overview approaches leadership article offers recommendations regarding leadership instructional leadership cultural leadership change leadership important urban school reform article rounds brief conclusion
background low testosterone obesity independent risk factors dysfunction nervous system including neurodegenerative disorders alzheimer disease study investigate independent cooperative interactions testosterone diet induced obesity metabolic inflammatory neural health indices central peripheral nervous systems methods male mice maintained normal high fat diet varying testosterone conditions four month treatment period metabolic indices measured rna isolated cerebral cortex sciatic nerve cortices used generate mixed glial cultures upon embryonic cerebrocortical neurons cultured assessment neuron survival neurite outgrowth peripheral nerve damage determined using paw withdrawal assay myelin sheath protein expression levels atpase activity levels results results demonstrate detrimental effects metabolic blood glucose insulin sensitivity proinflammatory cytokine expression responses caused diet induced obesity exacerbated testosterone depletion mixed glial cultures generated obese mice retain elevated cytokine expression although low testosterone effects persist vivo primary neurons cultured glial cultures generated high fat fed animals exhibit reduced survival poorer neurite outgrowth addition low testosterone diet induced obesity combine increase inflammation evidence nerve damage peripheral nervous system conclusions testosterone diet induced obesity independently cooperatively regulate neuroinflammation central peripheral nervous systems may contribute observed impairments neural health together findings suggest low testosterone obesity interactive regulators neuroinflammation combination adipose derived inflammatory pathways factors increase risk downstream disorders including type diabetes alzheimer disease
paper presents novel signal processing algorithm estimate scratching time scratching motion monitored using various methods evaluate itching behavior symptom associated many diseases given severity skin diseases accompanied itching related length scratching time various sensing systems developed measure scratching motion authors previously proposed bed sensing system helps monitor scratching motion patient asleep however systems determining scratching time burdensome task scorer determines scratching time visually observing signal obtained sensor addition scorer analyze several output wave shapes signals recorded patient asleep paper processing algorithm capable automatically extracting scratching time developed addition algorithm applied sensing systems
gentiana veitchiorum hemsl gentianaceae traditional tibetan medicine used treatment liver jaundice damp heat pathogen well headache chronic pharyngitis rapidultra performance liquid chromatography photodiode array detector quadrupole time flight mass spectrometry method developed fast accurate identification quantification chemical constituents veitchiorum fact eighteen compounds detected identified basis mass spectra fragment characteristics comparison published data especially fragmentation pathways iridoid glycosides flavone glycosides illustrated five compounds among quantified uhplc pda including swertiamarin gentiopicroside sweroside isoorientin isovitexin proposed method validated based analyses linearity accuracy precision recovery overall recoveries five analytes ranged rsd addition ten batches veitchiorum different areas also analyzed developed method rapid reliable identification quantification chemical constituents veitchiorum especially simultaneous qualitative quantitative analysis iridoid glycosides flavone glycosides sociedade brasileira farmacognosia published elsevier editora ltda
defect management quality inspection major strategy employed general contractors enhance construction management building projects however significant issues construction standard practice affects quality inspection including protracted procedures data entry redundancies confusion inefficient information management recognition construction issues paper proposes new practical approach applies building information modeling bim technology quality inspection defect management specifically bim digitally contains precise geometry relevant data needed support building structures describe object oriented cad using bim technology study proposes bim based defect management bimdm system site quality managers construction phase intended approach integrates web bim technologies bimdm system illustrate analyze defect information jobsite real time anticipated result effectively managed status results corrective works performed bimdm system applied selected case study building project taiwan verify proposed approach demonstrate effectiveness defect management practice utilizing bimdm system site quality managers better able track manage defects bim models accurate records photos combined results study demonstrate bimdm like system effective visual defect management platform integrating bim web technologies advantage bimdm system lies improving defect management efficiency site quality engineers managers also facilitating easy quality inspection identifying communicating bim environment authors expect effective use proposed bimdm would significantly assist site quality engineers managers systematically handle defect management work using bim technologies future construction projects
objectives considerable evidence suggests maternal psychopathology influences offspring probability reverse causal pathway rarely considered concern given around children manifest mental impairment early years study determines extent child behavior problems ages years associated mothers mental health years post birth study design longitudinal study methods data taken sample women mater university queensland study pregnancy birth cohort women mental health measured using mental disorder screening tool years post birth child behavior check list used measure internalizing combined social attention thought disorder aggression age years logistic regression used derive odds ratios confidence intervals number confounders used test independence results following adjustments child internalizing behaviors combined social attention thought disorder years measures child behavior problem years associated mothers meeting criteria mental health impairment years post birth moreover mothers children behavior problems years approximately times likely meet criteria conclusions mothers children behavior problems years age likely mental health impairment years post birth child health professionals cognizant motherechild relationship mutual mental health vulnerability royal society public health published elsevier ltd rights reserved
parameters non linear muskingum model nlmm usually assumed constant flood routing period recently need consider variable exponent parameter nlmm emphasised suitable continuous variable exponent parameter substantially improve model study appropriate continuous inflow based exponent proposed nlmm discharges inflow hydrographs future events may different larger discharges inflow hydrographs used calibration stage thus proposed inflow based function exponent parameter considered varies small range regardless size future inflow hydrographs durations safe extrapolation volumes inflow outflow hydrographs different lateral flows expected play relevant role flood routing procedure effects also considered research proposed model implemented tested three different sets benchmark hydrographs literature improvement performance proposed model considerable
abnormal vaginal bleeding common gynaecological symptom causes benign international federation gynaecology obstetrics proposed palm coein classification decrease heterogeneity studies gynaecological malignancies present abnormal bleeding vary according age patient origin upper versus lower genital tract important thorough history examination performed make distinction common malignancies presenting symptoms treatment discussed article according age patient considerable overlap reproductive age menopause article focuses children adolescents women reproductive age group published elsevier ltd
paper studies evolution crescent shaped dune influence injected flux scaling law wind tunnel experiment carried comparison experiment incorporates novel image processing algorithm recover evolutionary process theoretical experimental results agree well middle stage dune evolution deviate initial final stages suggesting crescent shaped dune evolution intrinsically scale variant crescent shape breaks unsaturated condition
increase urban population witnessed major cities worldwide efficient urban traffic planning modeling control indispensable paper propose novel macro model urban networks based queuing theory cast state space representation model junction incorporates switching mechanism capturing nonlinear dynamics normal traffic conditions linear evolution vehicle queues junction block back scenarios moreover competing models suffer quadratic increase computational cost every added junction model exhibits linear increase dimensionality thus significantly lowers computational demands simulation results proposed model validated standard micro modelling simulation package results demonstrate monte carlo simulation given correct model parameters proposed macro model well capture complex vehicle dynamics urban region thus paving way accurate analysis network development efficient urban traffic control strategies
objective child abuse exerts deleterious impact broad array mental health outcomes however neurobiological mechanisms mediate association remain poorly characterized use longitudinal design prospectively identify neural mediators association child abuse psychiatric disorders community sample adolescents method structural magnetic resonance imaging mri data assessments mental health acquired adolescents aged exposed physical sexual abuse participants assessed abuse exposure time participated mri scanning diagnostic structured interview time years later followed assess psychopathology time examined associations child abuse neural structure identified whether abuse related differences neural structure prospectively predicted psychiatric symptoms results abuse associated reduced cortical thickness medial lateral prefrontal temporal lobe regions thickness left right parahippocampal gyrus predicted antisocial behavior symptoms thickness middle temporal gyrus predicted symptoms generalized anxiety disorder thickness left parahippocampal gyrus mediated longitudinal association abuse antisocial behavior conclusion child abuse associated widespread disruptions cortical structure disruptions selectively associated increased vulnerability internalizing externalizing psychopathology identifying predictive biomarkers vulnerability following childhood maltreatment may uncover neurodevelopmental mechanisms linking environmental experience onset psychopathology
sigandu coastal tourism area located coastal zone batang district central java province coastal area faces severe coastal erosion problem indicated erosion processes occurred due jetty construction batang commercial port construction cause disturbance longshore transport equilibrium objective jetty construction trap sediment however classical problem erosion accration take place short time soon jetty construction finished local government batang district becomes aware erosion problem commenced september marine fisheries affair initiates solution applying low crested breakwaters structures using geotextile tube one month tube installation rapid sedimentation occurred formation salients tombolos behind structures beach profile calculation carried series monitoring cross section measurement well visual observation paper presents results monitoring beach activities case study expected example applied coastal areas similar coastal problems authors published elsevier ltd
background phosphatidylserine targeting positron emission tomography pet imaging labeled small molecule tracer crucial non invasive molecule imaging method apoptosis study semi automatic radiosynthesis biodistribution fluoropropionyl bis zinc dipicolylamine dpazn potential small molecule tracer pet imaging cell death alzheimer disease model performed methods dpazn synthesized modified pet synthesizer biodistribution determined normal mice pet images model obtained micro pet scanner results modified synthesizer total decay corrected radiochemical yield dpazn within min biodistribution results showed kidney highest uptake dpazn uptake radioactivity brain kept relatively low level whole observed time vivo dpazn pet images demonstrated accumulation radioactivity brain model mice brain normal mice conclusions semi automatic synthetic method provides slightly higher radiochemical yield shorter whole synthesis time dpazn manual operation method improved method give enough radioactivity high radiochemical purity dpazn vivo pet imaging results show dpazn seems potential cell death tracer imaging
obtain bachelor degree electrical engineering every student besides pure theory needs certain practical experience order feel comfortable beginning career throughout years university practical education conducted two different ways first one mandatory specialized internship real electric power plants substations possibility students grounds university includes classes dedicated practical activities classical laboratory exercises different engineering subjects report presents hybrid approach exercises combining elements design assemble electrical circuits close real world problems students would encounter careers
fibrosis formation excessive fibrous connective tissue organ tissue occurs reparative process response inflammation fibrotic diseases characterized abnormal excessive deposition fibrous proteins collagen disease commonly progressive leading organ disfunction failure although fibrotic diseases evolve similar way organs differences may occur result structure function specific organ liver fibrosis gold standard diagnosis monitoring progression disease biopsy invasive repeated frequently reason currently great interest identifying non invasive biomarkers liver fibrosis paper develop first time mathematical model liver fibrosis system partial differential equations use model explore efficacy potential currently used drugs aimed blocking progression liver fibrosis also use model develop diagnostic tool based combination two biomarkers
effects sic hfc ratios ablation mechanical properties hfc sic composites precursor impregnation pyrolysis pip process investigated systematically strength flexural compressive strength modulus increase sic hfc ratio improved compact stiff hfc sic matrix addition carbon fiber pyc interphase less reaction damage accounts improved mechanical properties hfc sic higher sic hfc ratios meanwhile weight loss erosion depth ifc sic improved increased sic hfc ratios therefore order balance ablation mechanical properties appropriate sic hfc ratio considered elsevier ltd rights reserved
context health informatics play critical role supporting local health departments lhds delivery certain essential public health services improving evidence base decision support however lhds informatics capacities optimum level efforts build capacities face ongoing challenges moreover little known lhd leaders desires future public health informatics objectives conduct qualitative analysis lhds future informatics plans perceived barriers accomplishing plans potential impact future advances public health informatics work public health enterprise methods research presents findings depth key informant interviews public health leaders informatics professionals lhds representing insights across united states interviewees selected basis size population lhd serves well level informatics capacity interviews transcribed verified double coded results major barriers informatics included staff capacity training financial constraints dependency state health agency small lhd size lack regionalization asked role leadership expanding informatics interviewees said leaders could make priority learning informatics creating appropriate budgets integrated information systems local health department leaders said desired data timely geographically specific addition lhd leaders said desired greater access clinical data especially around chronic disease indicators conclusions local health department leadership desires timely even real time data local health departments great potential benefit informatics particularly electronic health records advancing administrative practices service delivery financial human capital represents largest barrier interoperability public health systems highly desirable hardly achievable presence barriers
flow cytometry invaluable technology examination blood bone marrow tissue body fluids presence absence hematological disease used diagnostic follow testing increasingly important role detection small residual disease populations minimal residual disease mrd however flow cytometry immunophenotyping leukemia lymphoma highly dependent interpretation results increased complexity color instruments routinely used clinical laboratories knowledge disease defining populations increasingly important recognizing normal reactive patterns manuscript presents case studies flow cytometric patterns encountered routine screening samples sent leukemia lymphoma immunophenotyping focusing mainly cell disorders may missed incorrectly interpreted laboratory including hematopathologist performing test case studies used illustrate laboratory standardized approach interpretation flow cytometric data addition standardized approach cases emphasize importance interpretative skills technologist hematopathologists recognizing abnormal patterns detecting hematological malignancies
recursive branch bound algorithms often used either rigorously non rigorously refine isolate solutions global optimization problems systems equations inequalities involving nonlinear functions presented software library kodiak integrates numeric symbolic computation generic framework solution problems hyper rectangular variable parameter domains correctness generic branch bound algorithm self validating enclosure methods used namely interval arithmetic polynomials rational functions bernstein expansion formally verified algorithm three main instantiations systems equations inequalities constrained global optimization computation equilibria bifurcation sets systems ordinary differential equations latter category enable computation bisection heuristics reduce branching factor advantage taken partial derivatives constraint functions symbolically manipulated pavings unions box subsets continuum solutions underdetermined systems may also produced capabilities software tool outlined computational examples presented
removal gear box existing electric vehicle power train incorporating direct drive topology expected improve motor wheel efficiency firstly paper discusses need novel direct drive scheme employing single board motor electric machine drive design targets supermini direct drive scheme fixed based analytical equations benchmark data obtained commercially available motors drives transmissions literature study employing comprehensive vehicle dynamics model supermini machine design targets previously fixed refined yield desired dynamic steady state performance urban drive cycle board direct drive surface permanent magnet synchronous machine fractional slot concentrated windings stator designed machine performance analyzed using electromagnetic model conjunction maximum torque per ampere control scheme entire speed range motor results finite element analysis discussed detail show proposed direct drive scheme worth studying machine designed improved order obtain efficiency improvement drivetrain system hence extend driving range
psoriasis chronic inflammatory disease affecting mainly skin complicated psoriatic arthritis psa autoimmune skin disorder concerns world population date physiopathology psoriasis still completely elucidated many researches ongoing led example discovery pathway conventional therapeutic approaches local systemic route appeal various classes drugs complex mechanisms action non negligible side effects although therapy capable cure psoriasis current goal relieve symptoms longer possible good benefit risk ratio one principal limits conventional antipsoriatic drugs new formulations based nanoencapsulation promising opportunity answer limit offering optimization conventional antipsoriatic drug use higher activity lower side effects frequency application etc herein tried put perspective mechanistic insights histological immunological views proposed scientific literature last years order better comprehension psoriasis physiopathology resulting skin lesions psa therapeutic armamentarium different strategies management psoriasis discussed greater details finish field encapsulation nanoparticles broached order put forward recent advances innovative skin drug delivery systems isddss antipsoriatic active agents better efficacy safety compliance elsevier rights reserved
objective nsaids first line therapy axial spa axspa proportion patients responding nsaids differences non radiographic axspa axspa regard studied detail date aim study examine proportion patients axspa responding nsaids according current treatment recommendations methods consecutive anti tnf naive patients axspa included basdai score without received maximal nsaid doses case basdai score week later another nsaid prescribed next weeks continuous intake maximal doses recommended patients could reduce doses case intolerance improvement mri joints performed baseline week results outcomes except crp mri scores improved significantly weeks nsaids difference axspa subgroups assessment spondyloarthritis international society asas response partial remission rates week respectively time point basdai score still present patients reduced nsaid doses partly due intolerance patients continuously taken nsaids maximal dosage difference efficacy outcome compared taken reduced doses conclusion axspa patients similar response rates nsaids objective signs inflammation change weeks minority patients willing take maximal doses nsaids patients remained candidates tnf blockers results may influence future trial designs
backgroundallergen specific ige antibodies hallmark type allergy aim cross sectional study analyze sensitization profiles austrian adolescent population utilizing molecule based ige diagnosis methodsserum samples nonselected pupils salzburg austria tested immunocap isac ige reactivity single allergens sensitization profiles assessed statistically coordinated reported allergies resultsin population aged years showed ige reactivity least one allergen tested highest prevalence found phl grass pollen group mite allergens bet birch pollen fel cat majority participants showed complex sensitization profile reacted average allergens pollen sensitization highly prevalent mainly driven group grass allergens betulaceae family pla represented relevant weed diagnosed self reported allergies noted participants respectively correlated well vitro results among atopic individuals reported suffer least one allergy concordance found grass cat sensitization venom weed pollen positive individuals frequently asymptomatic conclusionsmore half tested adolescent population already established atopic status presenting complex ige reactivity profile dominated pollen sensitization detailed molecule based analysis allows determining relevant biomarkers monitoring atopic status populations
previous studies noted narcissists cases experience benefits current study adds discussion examining whether age might moderate links narcissism self reported benefit life satisfaction observer reported benefit observer ratings personality sample college students family members authors demonstrate narcissism positively correlates life satisfaction adolescents emerging adults adult participants addition relationship narcissism observer reported neuroticism weakly negative undergraduate students significant positive mothers taken together results suggest narcissism beneficial adolescents emerging adults adults sets analyses also pointed importance studying narcissism multifaceted construct findings discussed respect personality development theories emphasize adult role adoption
present research examined messages advocating different intergroup ideologies affect outcomes relevant minority group members ability exert power exchanges dominant group members expected salient multiculturalism would positive implications minority group members feelings power virtue highlighting essential contributions make society empowering effect would evident connection alternative ideologies color blindness dominant group members results across four studies involving different participant populations operationalizations ideology ethnic minority groups experimental settings consistent hypotheses indicated effects salient multiculturalism feelings power downstream implications expectations control ostensibly upcoming intergroup interaction general goal directed cognition
purpose review cadasil cerebral autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy important disease consider differential diagnosis migraine aura review examines current literature regarding migraine cadasil well diagnostic treatment modalities recent findings recent studies shown smoking modifiable risk factor progression cadasil chabriat stroke specific imaging changes findings clinical exam predict disease progression however migraine symptoms often precede mri changes guey cephalalgia recent paper migraine treatment cadasil reevaluates prevailing belief vasoconstrictive abortive medications contraindicated patients tan markus plos one summary cadasil autosomal dominantly inherited vasculopathy causing ischemic pathology younger individuals due mutation notch gene mutation results impaired arterial contractility due accumulation granular osmiophilic extracellular material gom vascular smooth muscle cells vsmcs clinical manifestations include migraine without aura cognitive decline ischemic events mood disorders presenting symptom often migraine aura characteristic mri changes often present genetic screening available confirm notch mutation pathognomic changes often seen skin biopsy treatment migraine similar general population notable specific differences studies cadasil small vessel arteriopathies migraine may help understand pathophysiology conditions help treatment development
objective current study examine possible risk school bullying victimization exposure media violence callous unemotional traits impulsivity narcissism protective family peer school social support factors might associated cyberbullying cyber victimization employing longitudinal two wave design sample consisted girls adolescents living cyprus findings suggested cross sectional longitudinal associations school bullying cyberbullying school victimization cyber victimization furthermore callous unemotional traits longitudinally related cyberbullying media violence exposure risk factor leading cyberbullying cyber victimization family social support protective factor types adjustment problems finally family social support protected adolescents living single parent households cyber victimized friendships supportive
women underrepresented field computer science project aims help secondary school girls develop insight role computers play society learn key skills computing including computer programming exposure computer science home school environments encouragement family peers leading factors influence girls decisions pursue careers computer science factors include girls perception problem solving ability understanding diverse applications computer science related career paths potential positive social impact paper describes design school computing programme codeplus uses novel century learning model pre post questionnaire used explore girls intentions study confidence study perception career gender perception profession self efficacy following participation codeplus programme preliminary results comparing pre questionnaire results male control group highlight differences girls see terms capabilities future potential initial post questionnaire findings show significant increase participants perceived programming ability
previous neuroimaging studies gyrification possible marker early neurodevelopment schizophrenia patients reported inconsistent results addition remains unclear whether aberrant gyrification schizophrenia patients present associated cognitive impairment one core features schizophrenia magnetic resonance images obtained patients first episode schizophrenia healthy control subjects using freesurfer software local gyrification index lgi entire cortex compared groups relationship lgi performance wisconsin card sorting test wcst also examined subgroup patients compared controls patients showed significantly higher lgi wide range bilateral frontal regions well right inferior parietal bilateral occipital regions number wcst categories archived patients negatively correlated lgi mainly rostral middle frontal anterior cingulate regions right hemisphere findings suggested widespread hypergyrification pattern schizophrenia patients supported early neurodevelopmental abnormalities results also suggested executive dysfunction schizophrenia patients may least partly related aberrant neurodevelopment especially right frontal regions
paper provides novel analysis methods detailed simulations determining impact band emissions oobe adjacent band wireless services mobile receive wireless services using interference adjacent cellular bands operational digital wireless receive system example demonstrate impact interference adjacent cellular band transmitters determine performance impact outage satellite receivers realistic roadway conditions paper presents new methods determining appropriate oobe spectral masks use new cellular subscriber transmitters paper considers realistic propagation traffic conditions five cities throughout united states offers approaches engineering community may use determine interference conditions new cellular fixed broadband mobile services adjacent spectrum bands existing receive mobile receiver systems satellite radio
dementia lewy bodies characterized synuclein accumulation degeneration dopaminergic cholinergic pathways gain overview brain systems affected neurodegeneration characterized fdg pet metabolic connectivity dementia lewy bodies patients compared healthy controls using sparse inverse covariance estimation method graph theory performed whole brain anatomically driven analyses targeting cholinergic dopaminergic pathways synuclein spreading first revealed substantial alterations connectivity indexes brain modularity hubs configuration namely decreases local metabolic connectivity within occipital cortex thalamus cerebellum increases within frontal temporal parietal basal ganglia regions also long range disconnections among brain regions supporting disruption functional hierarchy characterizing normal brain anatomically driven analysis revealed alterations within brain structures early affected synuclein pathology supporting braak early pathological staging dementia lewy bodies dopaminergic striato cortical pathway severely affected well cholinergic networks extensive decrease connectivity networks lateral capsular network significantly towards occipital cortex altered patterns metabolic connectivity unveil new invivo scenario dementia lewy bodies underlying pathology terms changes whole brain metabolic connectivity spreading synuclein neurotransmission impairment
review provides comprehensive view translational research aimed elucidating pathophysiology pediatric lower urinary tract dysfunction lutd web search conducted according combinations keywords significance article defined author dramatic evolution mass analysis method genomes transcripts proteins enabled comprehensive analysis molecular events underlying diseases methodologies also applied pediatric lutd genetic analyses syndromes underlying daytime incontinence urofacial ochoa syndrome may creating prototype new research approach nocturnal enuresis long studied genetically several candidate loci reported however pursuit enuresis genes abandoned partly genetic association enuresis phenotype bladder renal type could linked enuresis associated diabetes insipidus provided new insights etiology diseases chronobiological approach may shed new light area posterior urethral valves neurogenic bladders attracted interest pediatric urologists smooth muscle biology bladder bladder exstrophy cloacal anomalies rare major anomalies caused defective urorectal development recently studied genetic standpoint translational studies pediatric lutd may extended adult bladder disease application precision medicine diseased children
almost one four germans registered sports club nowadays sport acknowledged integral component healthy lifestyle numerous studies provide evidence benefits sports health however million sports injuries per year diminish health benefits sport description epidemiology sports injuries german sports club identification focal areas development implementation prevention measures continuous questionnaire based injury monitoring club sports injuries reported respective sports insurance full survey among selected federal sports associations since sample sports injuries established two thirds injuries reported soccer handball basketball volleyball although one third sports club members registered team sports number women soccer injuries risen ankle injuries decreased contrast rate knee injuries increased days disability dropped steadily since inpatient hospital days decreased days whereas share injuries needed surgery increased team ball sports still clear focal area injury prevention participation injury risk highest group prevention ankle injuries seems headed right direction knee injuries increasing team ball sports become popular among women prone severe knee injuries prevention programs tailored toward specific situation needs targeted sports participants
background cardiovascular disease leading cause death worldwide non adherence recommended regimen among patients cardiovascular diseases represents significant problem could lead increase cardiovascular diseases purpose study aimed assess effects short message system sms reminders adherence healthy diet medication cessation smoking among adult patients cardiovascular diseases methods randomized controlled trial design three groups used study non probability convenient sample patients recruited study participants assigned randomly experimental group received sms regarding adherence healthy diet medication smoking cessation placebo group received general messages control group routine care morisky item medication adherence scale mmas mediterranean diet adherence screener medas readiness quit ladder used assess patients adherence medication adherence mediterranean diet smoking cessation respectively outcomes assessed beginning study three months later following completion intervention result one way anonva used assess study hypothesis significant differences study groups found terms adherence medication adherence healthy diet however significant difference found groups terms intention quit smoking number cigarettes smoked respectively conclusion documented sms effective improving adherence healthy diet medication sms could promising solution management different chronic diseases implication study recommended apply short message system sms via cellphone services improve patient adherence healthy diet medication however research needed support effectiveness sms elsevier ireland ltd rights reserved
background efficacy psychoeducation well documented treatment relapse prevention schizophrenia recently also bipolar disorder however recurrent depression controlled studies focusing efficacy psychoeducation conducted aims randomized study tests efficacy treatment usual supplemented psychoeducative programme patients recurrent depression treated community mental health centres cmhc denmark primary outcome measurements concern decline consumption psychiatric inpatient services decline beck depression inventory bdi methods eighty patients randomized either psychoeducative programme consisting eight sessions hours duration year outpatient follow cases year outpatient follow controls patients monitored years randomization data collected interviews including bdi drug treatment social measurements register data concerning use psychiatric services results year follow significant reduction consumption psychiatric inpatient services bdi found however uniform case control patients drop non compliance significantly frequent among patients randomized control group furthermore follow case group got significant stronger attachment labour market control group conclusions primary hypothesis could confirmed secondary outcome measurements concerning drop non compliance attachment labour market significantly favour cases
low testosterone associated late onset hypogonadism loh obesity recently studies shown four single nucleotide polymorphisms snps associated testosterone levels populations european descent therefore investigated whether snp loci related low testosterone loh obesity chinese han population ruling morbidities dna prepared men aged years low serum testosterone defined total testosteronet associated increased risk low total testosterone low cft loh adjusted factors odds ratio significantly correlated weight bmi associated increased risk overweight obesity adjusted factors odds ratios ors summary study provided convincing evidence associated risk low testosterone loh chinese populations first find significantly correlated risk overweight obesity chinese populations however large functional studies warranted confirm findings
novel automated method determination boron based use pulsed flows developed applied determination element samples tap water ocean water eye drops method implemented means multi pumping system consisting three solenoid micropumps photometric detector exploits reaction azomethine presence boron system runs control open source microcontroller main operational parameters optimized given particular kinetics reaction stopped flow period min included allow color development method presents linearity range good precision detection quantification limits respectively samples tap water eye drops could successfully analyzed employing minute stop time providing maximum sampling frequency samples order overcome matrix effect caused high saline concentration ocean water samples required stop times min providing sampling frequency samples recoveries eye drops drinking water ocean water obtained method considered accurate fit purpose elsevier rights reserved
background informal care essential many people dementia pwd often results considerable burden caregiver perseverance time instrument integrates aspect perceived burden caregiver capacity cope burden contrast available instruments measure solely burden caregiving aim study extend insight psychometric properties perseverance time instrument specifically construct validity responsiveness predictive validity within population informal caregivers pwd methods data two studies among informal caregivers community dwelling pwd netherlands used first study included caregivers single region netherlands lasted year second cross sectional nationwide study caregivers pwd questionnaires studies included questions regarding demographics informal care perseverance time informal caregiver outcomes caregiver strain index self rated burden scale care related quality life instrument visual analogue scale health scores construct validity responsiveness assessed using hypothesis testing approach predictive validity demographic characteristics perseverance time living situation year living home institutionalized deceased assessed multivariable multinomial regression results one hypotheses regarding construct validity met three five hypotheses regarding responsiveness met perseverance time scores baseline associated living situation year unlike age sex relationship pwd perseverance time strongly increased predictive power living situation year index addition demographic characteristics conclusions study supports previous findings regarding construct validity perseverance time instrument adds new evidence good construct validity responsiveness predictive validity predictive power perseverance time scores living situation exceeds predictive power burden measures indicates informal care important factor maintaining patient home
online extraction kernel principal components gained increased attention several algorithms proposed recently explore kernelized versions generalized hebbian algorithm gha well known principal component analysis pca extraction rule corisequently convergence speed algorithms accuracy extracted components highly dependent proper choice learning rate problem dependent factor paper proposes new online fixed point kerriel principal component extraction algorithm exploring minimization recursive least square error function conjugated approximated deflation transform using component estimates obtained algorithm implicitly applied upon data proposed technique automatically builds concise dictionary expand kernel components involves simple recursive equations dynamically define specific learning rate component extraction linear computational complexity regarding dictionary size compared state art kernel principal component extraction algorithms results show improved convergence speed accuracy components produced proposed method five open access databases
purpose review outcome total hip arthroplasty tha using short femoral stem hips methods records hips men women aged mean years underwent cementless tha using short femoral stem single senior surgeon reviewed diagnosis included avascular necrosis ankylosing spondylitis rheumatoid arthritis post traumatic arthritis hurler syndrome clinical outcome assessed using harris hip score radiological outcome assessed according modified gruen zoning system stem positioning neutral varus valgus bone contact evaluated fixation early host response well subsidence changes calcar region zone trabecular response trabecular attachment spot welds cortical hypertrophy pedestal formation determined heterotopic ossification graded brooker classification results mean follow period years mean harris hip score improved hips achieved immediate postoperative stability patient thigh pain four hips varus placement stem asymptomatic remained stable without migration evidence proximal load transfer endosteal spot welds endosteum stem zones noted hips sides hips lateral side one year stems showed evidence osseointegration none subsidence progressive varus migration radiolucent line osteolysis around stem pedestal formation buttressing prosthesis tip cortical hypertrophy one patient grade heterotopic ossification clinically significant one patient leg lengthening one patient discharging sinus loosened acetabular component intrapelvic migration years underwent implant removal debridement one patient developed crack proximal femur even smallest stem stem fixed cerclage wiring remained stable migration conclusion short femoral stem design transfers load proximally prominent lateral flare achieved good short term outcome younger patients nonetheless ease removal preservation bone time revision guide choice design short stem
load frequency control one important issues power system operation paper fractional order pid fopid controller based gases brownian motion optimization gbmo used order mitigate frequency exchanged power deviation two area power system considering governor saturation limit fopid controller derivative integrator parts non integer orders determined designer fopid controller flexibility pid controller gbmo algorithm recently introduced search method suitable accuracy convergence rate thus paper uses advantages fopid controller well gbmo algorithm solve load frequency control however computational load higher conventional controllers due complexity design procedure also gbmo based fuzzy controller designed analyzed detail performance proposed controller time domain robustness verified according comparison controllers like gbmo based fuzzy controller controller used load frequency control system confronting model parameters variations isa published elsevier ltd rights reserved
background endocrine evaluation long term follow seven six male patients williams beuren syndrome wbs given method data obtained patients medical records patients underwent hormonal analyses four underwent oral glucose tolerance test ogtt results mild hypercalcemia three overt hypothyroidism subclinical hypothyroidism detected three patients four patients thyroid hypoplasia one thyroid agenesis growth hormone deficiency ghd determined one patient impaired glucose tolerance igt found three adolescents adolescents early onset puberty follow duration years mean growth velocity end first second years therapy respectively patients neurodevelopment retardation continuing special education conclusions thyroid hypoplasia common agenesis seen patients wbs therefore thyroid hormones measured newborn period annually ghd kept mind patients decreased igt might detected patients wbs even adolescence
although non motor symptoms nms parkinson disease common also early stages disease still recognized screening tools non motor symptoms non motor symptoms questionnaire nmsquest help clinicians recognize nms evaluate patients could require assessment specific treatments validate adapted italian version nmsquest study psychometric properties italian patients self completed italian nmsquest underwent standard clinical evaluation including motor assessment hoehn yahr staging unified parkinson disease rating scale part iii non motor assessment montreal cognitive assessment beck depression inventory neuropsychiatric inventory epworth sleepiness scale scale outcomes parkinson disease autonomic movement disorder society sponsored revision unified parkinson disease rating scale part somatic comorbidities quantified using modified cumulative illness rating scale cirs seventy one subjects assessed mean age years women mean duration disease years median italian nmsquest showed adequate satisfactory clinimetrics terms data quality precision acceptability internal consistency reliability significant correlation found nmsquest non motor assessment scales significant correlation appeared motor severity well age patients disease duration levodopa equivalent daily dose dopa dopamine agonists assumption cirs total score italian version nmsquest resulted reliable instrument screening nms italian patients
nowadays network control systems present common approximation connectivity issue solved based time delays coupling external factors however approach tends complex terms time delays inherent local phase missing therefore necessary study behavior delays well integration onto differential equations bounded delays related time delays needs known priory dynamic real time behavior order understand dynamic phase behavior objective paper show way include data frequency transmission time delays bounded parameters dynamic response real time scheduling approximation considering local phase situation related control law designed considering fuzzy logic approximation nonlinear time delays coupling main advantage integration behavior extended state space representation keeping certain linear bounded behavior leading stable situation events presentation based accurate data transmission rate expected conform basics local phase missing result local bounded time delays lack tide synchronization modeling approximation
children medical complexity victims medical child abuse may similar clinical presentations atypical unexplained signs symptoms due rare diseases may lead providers suspect medical child abuse present conversely medical child abuse may cause coexist medical complexity careful consideration whether medical child abuse present essential assessing child medical complexity since either diagnosis significant consequences children families
background public health public safety clinical implications violent events among adults mental illness significant however causes consequences violence victimization among adults mental illness complex well understood limits effectiveness clinical interventions risk management strategies study examined interrelationships violence victimization psychiatric symptoms substance use homelessness patient treatment time method available data integrated four longitudinal studies adults mental illness assessments took place baseline months depending parent studies protocol data analysed autoregressive cross lag model results violence victimization leading indicators affective symptoms leading indicator drug alcohol use leading indicators violence victimization respectively psychiatric symptom clusters affective positive negative disorganized cognitive processing increased likelihood experiencing least one subsequent symptom cluster sensitivity analyses identified group based differences magnitude effects heterogeneous sample conclusions violent events demonstrated unique shared indicators consequences time findings indicate mechanisms reducing violent events including trauma informed therapy targeting internalizing externalizing affective symptoms cognitive behavioral psychopharmacological interventions integrating substance use psychiatric care finally mental illness violence victimization research move beyond demonstrating concomitant relationships instead focus lagged effects improved spatio temporal contiguity
paper presents multi objective optimization based robust controller design boost converter controlled fpga field programmable gate array main aim proposed design technique obtain fixed low order robust controller reliable easy implement low cost real time digital system improved proposed control design method direct closed loop pole position assessment using metric based robust optimal regional closed loop pole assignment technique optimal solution obtained using multi objective pareto front search genetic algorithm paper also presents simulated practical experimental results implemented optimized robust controller fpga controlling boost converter sake comparison proposed controller design method additional auto tuned pid controller designed along robust controllers based mixed sensitivity loop shaping method elsevier ltd rights reserved
power electronic circuit pec design optimization significant problem scientific engineering communities due complex search space pec optimization problem lots works tried use evolutionary computation algorithms solve gained great progress however existing based algorithms pec still complex algorithm design solutions still needed improved considering solution accuracy therefore design simpler yet powerful algorithm solve pec problem efficiently great need paper makes first attempt proposing novel differential evolution kind new simple yet efficient algorithm pec design optimization advantage paper algorithm first time directly applied pec design optimization making approach simple use results compared obtained using genetic algorithm particle swarm optimization pso brain storm optimization bso results show algorithm outperforms pso bso pec design optimization study
finite element mesh generators exist public domain even based parametric device description typical mesh generator requires man machine interaction define points boundary conditions work non stop optimization iterations need mesh dynamically evolving iterations optimization variables changing parameters mesh generators exist rare commercial easily available researchers except great cost never code modify suit individual needs take regular open source mesh generator write script based interface open source run non stop optimization use create non destructive evaluation system army ground vehicles defect characterization use equally machine design simple scheme averaging neighbour heights gives smooth geometry without use bezier curves mesh runs central processing unit finite element optimization graphics processing unit speed practicable testing times
human based energy harvesters attractive sustainable replacements batteries power wearable implantable devices body sensor networks work presented knee joint energy harvester keh introduced power customer built wireless communication sensing node wcsn keh used mechanical plucking technique provide sufficient frequency conversion resonant frequency keh generate high power required actuated knee joint simulator reproduced knee joint motion human gaits walking frequency energy generated first stored reservoir capacitor released wcsn burst mode help energy aware interface wcsn deployed three axis accelerometer temperature sensor light detector data sensing jennic microcontroller utilised collect transmit measured data base station placed distance energy generation keh energy distribution system characterised real time house built set results showed keh generated average power output powering wcsn charging reservoir capacitor keh power wcsn period every results also clearly illustrated energy generated keh distributed system highlighted importance using high performance power management approach improve performance whole system
delta fatty acid desaturase membrane bound enzyme rate limiting factor biosynthesis polyunsaturated fatty acids study novel delta desaturase gene cloned bombyx mori bmddes sequencing analysis revealed bmddes open reading frame encodes amino acids heterologous expression yeast demonstrated bmddes could synthesize gamma linolenic acid gla delta utilizing endogenous substrate linoleic acid delta found bmddes transcripts distributed almost mori tissues high expression levels observed instar larval pupal adult moth stages functional analysis bmddes performed measuring mrna levels temperature stress fungal infection rna interference rnai results indicated highest expression bmddes observed low temperatures degrees fungal infection qpcr analysis demonstrated bmddes mrna levels pupa bmddes rnai treatment significantly reduced compared control group findings suggest bmddes induces formation third carbon carbon double bond carbon chain also leads sensitivity low temperature stress fungal infection results imply bmddes key gene gamma linolenic acid pathway mori development korean society applied entomology taiwan entomological society malaysian plant protection society published elsevier rights reserved
objectives aim study study focal cerebellar pathology early stages multiple sclerosis using ultra high field magnetization prepared inversion contrast rapid gradient echo mprage materials methods twenty early stage relapsing remitting patients underwent mprage acquisition magnetic resonance imaging mri images acquired different resolutions mri total cerebellar lesion load volume andmean cerebellar lesion volume compared across images using wilcoxon signed rank test mean relaxation times lesions normal appearing tissue well contrast noise ratio cnr measurements also compared using wilcoxon signed rank test multivariate analysis applied assess contribution mri metrics clinical performance patients results mprage showed significantly higher lesion load compared mprage plaques judged leukocortical mprages instead identified lesions mprage cortical lesion cnr significantly higher mprages total lesion load well total mean lesion volume obtained mprage significantly predicted attention adjusted verbal fluency adjusted motor performance adjusted conclusions study demonstrates value mprage study cerebellum early patients mprage provides accurate anatomical description white gray matter pathology compared mprage likely due improved spatial resolution lower partial volume effects higher cnr
invasive fungal infections ifi cause serious morbidity mortality among febrile patients chemotherapy induced neutropenia cin order evaluate incidence treatment outcome factors associated ifi patient population thailand retrospectively reviewed medical record patients admitted siriraj hospital january june criteria used diagnosed ifi european organization research treatment cancer invasive fungal infections cooperative group national institute allergy infectious diseases mycoses study group eortc msg consensus criteria three hundred ten episodes chemotherapy induced neutropenia occurred patients ifi found episodes occurred patients received chemotherapy hematological malignancies incidence ifi among patients hematologic malignancies commonly occurred aml patients patients received aggressive induction chemotherapy regimens aml highest incidence ifi episodes candidiasis aspergillosis zygomycosis fusariosis probable possible ifi ifi related mortality clinical factor associated ifi temperature degrees febrile neutropenia higher mortality rate seen patients aged years serum albumin level
aims objectives explore factors influence use escalation success halting conflict acute psychiatric inpatient setting background escalation use verbal nonverbal communication reduce eliminate aggression violence escalation phase patient behaviour although escalation first line intervention aggression management acute psychiatric settings little known use effectiveness technique design retrospective case note analysis methods patient involvement conflict aggression containment coerced medication first two weeks admission recorded frequency order conflict containment events identified shift sequences events occurring shifts involving escalation analysed sequences escalation ended pattern conflict containment categorised successful others categorised unsuccessful results half patients experienced escalation first two weeks admission majority experiencing multiple episodes escalation successful approximately cases successful escalations preceded fewer less aggressive conflict events compared unsuccessful escalations frequently followed administration pro nata medication patients history violence likely experience escalation likely unsuccessful conclusions escalation frequently effective halting sequence conflict acute inpatient settings patients history violence may specifically challenging relevance clinical practice findings provide support escalation practice suggest nurses may lack confidence using technique risk violence greater providing evidence based staff training may improve staff confidence use potentially powerful technique
nineteenth century dispute existence lung alveolar epithelium remained unsolved invention electron microscopy application lung early ewald weibel became master lung showed alveolar epithelium covered lining layer containing surfactant weibel also explained phenomenon non nucleated plates observed already albert kolliker weibel significant contribution development stereological methods therefore quantitative characterization lung structure revealing structure function relationships became possible today spectrum methods study fine structure lung extended significantly cryo preparation techniques available necessary immunogold labeling molecules energy filtering techniques used detection elements also major improvements stereology thus providing versatile toolbox quantitative lung phenotype analyses new dimension added techniques depending desired sample size resolution spectrum ranges array tomography via serial block face scanning focused ion beam scanning electron tomography datasets provide new insights lung ultrastructure biomedical ever developing field high resolution remains unparalleled moreover unique advantage providing open view cells tissues within full architectural context therefore remain indispensable tool better understanding lung functional design
study presents numerical simulations advective flow composite geomembrane geosynthetic clay liner gmb gcl past gcls considered homogeneous materials actually consist special layered composite structure combines two types materials geotextiles bentonite connected together various processes one could imagine gcl hydrates different water retention properties geotextile bentonite affect hydraulic behaviour engineered systems including gmb gcl composite liners investigate question advective flow composite liner modelled gcl damaged gmb numerically simulated evaluate hydraulic properties unsaturated geotextile bentonite influences temporal evolution advective flow composite liners results compared measured water retention curves geotextiles bentonite simulation indicates reproduced flow rate influenced desaturation geotextile occurs bentonite hydrates reduction flow rate thus governed hydraulic conductivities geotextile bentonite vary degree saturation
paper discuss development novel rapid prototyping method makes process creating tangible electronic artifacts faster easier method makes use new paper like material given form hand using stationary objects material changes stiffness becomes harder soon modeling process furthermore material integrated within electronic circuits using magnetic connectors silver discussed method conceptualized using people centered design approach implementation led engineering approach conceptualization process well implementation discussed rapid prototyping method detailed paper along example scenarios said implementation could useful
photocatalytic hydrogen evolution semiconductors efficient method solar energy conversion heterostructural photocatalysts separated photoexcited carriers exhibit efficient photocatalytic hydrogen evolution without catalysts study heterostructures comprising xznxs ycdys phases prepared replacement sulfuration process high temperature using powders precursor highly crystalline xznxs ycdys heterostructures without noble metal catalysts present stable highly effective photocatalytic hydrogen evolution rate visible visible light irradiations due synergistic effects xznxs ycdys elsevier rights reserved
gliding important flight mode insects saves energy long distance flight without wing flapping study investigated influence locust wing corrugation aerodynamic performance gliding mode low reynolds number numerical simulations using two dimensional navier stokes equations applied study gliding flight reveals interaction forewing hindwing lift corrugated airfoil locust wing decreases wing root tip simulation results show pressure drags forewing hindwing increase increase wing thickness lift drag ratio airfoil marginally affected corrugation airfoil geometric parameters analysis locust wing also carried includes corrugation height corrugation placement shapes leading trailing edges
work aimed evaluate aspects construction operation full scale best management practices effects infiltration loading rate two systems studied filter swale trench fst infiltration well units field essays full scale measurements made order assess soil permeability fine particles transportation geotextile blanket permeability determined operation results pointed soil transportation inside fst systems despite installed protections material responsible diminishing geotextile reduction fst full scale infiltration loading rates varying
major health policy creation changes including governmental private policies affecting health care delivery based health care reform health care reform global issue years united states seen proposals multiple reforms years successful health care proposal united states involvement federal government short lived establishment first system national medical care south century united states influenced progressivism leading initiation efforts achieve universal coverage supported republican presidential candidate theodore roosevelt franklin roosevelt democrat included publicly funded health care program drafting provisions social security legislation eliminated final legislation subsequently multiple proposals introduced starting president harry truman proposed universal health care proposal lyndon johnson social security act created medicare medicaid proposals ted kennedy president richard nixon promoted variations universal health care presidential candidate jimmy carter also proposed universal health care followed effort president bill clinton headed first lady hillary clinton enacted law finally election president barack obama control houses congress democrats led passage affordable care act aca often referred obamacare signed law march since aca obamacare become centerpiece political campaigning republicans control presidency houses congress attempting repeal replace aca
guided indirect evidence recent approaches propose tripartite crosstalk among interoceptive signaling emotional regulation low level social cognition examined neurocognitive convergence domains first performed three meta analyses functional magnetic resonance imaging studies identify areas consistently coactivated three systems multi level kernel density analysis mkda revealed major overlaps right anterior insular frontotemporal regions viz orbitofrontal inferior frontal gyri amygdala mid temporal lobe subcortical structures second explored domains patients fronto insulo temporal damage relative controls patients showed behavioral impairments interoception emotional processing social cognition preservation cognitive functions convergent results studies offer direct support model insular frontotemporal regions integrating interoception emotion social cognition elsevier ltd rights reserved
objective determine whether month contraceptive vaginal ring cvr delivering ulipristal acetate upa inhibit ovulation cycles study design randomized dose finding parallel group clinical trial fifty five healthy women normal ovulation baseline randomized receive low dose day high dose day upa cvr two consecutive week treatment periods followed recovery cycle subgroup women received levonorgestrel lng orally twice end week ring periods end week treatment primary outcome ovulation suppression assessed transvaginal ultrasound hormone levels secondary outcomes included endometrial safety bleeding patterns results subjects showed normal ovulation baseline recovery ovulation suppression seen treatment cycles low high dose respectively benign progesterone receptor modulator associated endometrial changes paec seen treatment week resolved recovery cycle cases heavy bleeding occurred near end week treatment single dose lng every weeks reduced increase endometrial thickness second treatment period prevented excessive bleeding conclusion month upa cvr may become effective long acting user controlled estrogen free contraceptive greatest suppression ovulation seen day ring implications month cvr delivering upa day become effective user controlled estrogen free contraceptive method benign paec treatment returns normal discontinuation prevention occasional excessive withdrawal bleeding either progestin using higher upa levels increase follicle suppression may permit prolonged treatment elsevier inc rights reserved
purpose paper adopt cmos image sensors achieve real time obstacle avoidance system wheeled mobile robots robot continually detect surroundings avoid obstacles move toward target area study cmos image sensor used detect small obstacles obtain information concerning environment front robot order avoid obstacles rolling speed direction robot left right wheels determined image channel weighting parameter method proposed study experimental results verified image captured cmos image sensor obstacle avoidance system wheeled mobile robot combined atmega embedded microcontroller helps robot avoid obstacles reach target area
work presents comparative study two approaches calibrate radar rainfall real time weather radar provides continuous measurements real time errors either meteorological instrumental nature locally gauge measurements greater performance radar measurements used improve radar estimates one way via state space representation associated kalman filter algorithm singlesite modeling approach use linear calibration model applied multivariate state space model proposed used multiple site approach work aims discuss compare two different state space formulations based data set
well recognized medications important role play preventing relapse bipolar disorder impact treatments rates admission hospital particular less well studied combined data hospitalization randomized controlled trials network meta analysis found published evidence demonstrates significant reductions admission rates compared placebo lithium risk ratio confidence interval valproate combination lithium valproate carbamazepine olanzapine evidence base contributing estimates remains fairly small leading broad confidence intervals estimates effect precise estimates could obtained unpublished outcomes data trials area became available several pharmacological treatments appear effective reducing need hospital admission people bipolar disorder
oil gas industry processing visualizing models paramount importance making exploratory production decisions hydrocarbons reservoirs entities buried deep earth crust simplified geological model mimics environment generated run simulations help understand geological physical concepts task visually inspecting models advocate use cutaways illustrative technique emphasize important structures parts model selectively discarding occluding parts keeping contextual information however complexity reservoir models imposes severe restrictions limitations using generic illustrative techniques previously proposed computer graphics community overcome challenge propose interactive cutaway method strongly relying screen space gpu techniques specially designed inspecting reservoir models represented corner point grids industry standard elsevier inc rights reserved
aim review available literature obese patients treated laparoscopic roux gastric bypass lrygb laparoscopic sleeve gastrectomy lsg failed laparoscopic adjustable gastric banding lagb order compare clinical outcomes two methods systematic literature search performed pubmed central scopus databases accordance prisma guidelines eight studies met inclusion criteria incorporating patients procedures associated comparable complications conversions mean hospital stay weight loss months lrygb group excess weight loss ewl bmi reduction months increased well designed randomized controlled studies comparing revisional lrygb lsg necessary assess outcomes
study aims presenting process machine design agricultural implements means reference model formulated purpose explaining development activities new products serving guideline coach human resources assist formalizing process small medium sized businesses smb employees methodology used included process modeling carried case studies smb study reference models literature modeling formalism used based idef standard identifies dimensions required model detailing input information activities tasks knowledge domains mechanisms controls information produced dimensions organized spreadsheets graphs result reference model activities tasks obtained distributed four phases design process evaluation model carried companies participating case studies experts concluded model explains actions needed develop new products smb
objectivesreviewed epidemiology clinical characteristics mechanisms treatment tuberculosis associated chronic obstructive pulmonary disease data sourcewe searched pubmed embase cinahl inception june used following search terms tuberculosis copd tuberculosis associated copd forth types study chosen results conclusionchronic obstructive pulmonary disease copd tuberculosis significant public health problems particularly developing countries although smoking conventional risk factor copd nonsmoking related risk factors biomass fuel exposure childhood lower respiratory tract infections chronic asthma outdoor air pollution prior history pulmonary tuberculosis become important risk factors copd particularly developing countries past history tuberculosis risk factor chronic airflow obstruction reported several studies may develop course tuberculosis completion tuberculosis treatment developing countries large burden tuberculosis contribute significantly burden chronic airflow obstruction prompt diagnosis treatment tuberculosis emphasized lessen future burden chronic airflow obstruction
dependable complex systems often operate variable non stationary conditions requires efficient extensive monitoring error detection solutions among many paper focuses anomaly detection techniques monitor evolution specific indicators time identify anomalies deviations expected operational behavior timely identification anomalies dependable fault tolerant systems allows timely detect errors services react appropriately paper investigate possibility monitor evolution indicators time using random walk model indicators belonging operating systems specifically study linux red hat approach based experimental evaluation large set heterogeneous indicators acquired different operating conditions terms workload faultload air traffic management target system statistical analysis based best fitting approach aiming minimize integral distance empirical data distribution reference distributions outcomes analysis show idea adopting random walk model development anomaly detection monitor critical systems operates operating system level promising moreover standard distributions laplace cauchy rather normal used setting thresholds monitor studies involve new application different operating system new layer application server allow verifying generalization approach fault tolerant systems monitored layers set indicators elsevier ltd rights reserved
study examines neighborhood activity spaces nas year old children seven schools london canada data global positioning system gps loggers worn days used isolate test measures children pedestrian based neighborhood activity maximum distance traveled home relative time spent neighborhood settings descriptive linear regression analyses examined influence individual perceptual environmental factors neighborhood use travel participants spent large portion school time nas although traveling far home occasion children time average spent within short distance home participants spent little free time broader neighborhood settings school travel mode independent mobility among strongest predictors distance traveled time spent close home perceptions neighborhood safety neighborhood type nearby land uses also influenced local activity
water resource shortage pollution seriously threatened survival development developing countries india specific economical social circumstances complete adoption developed countries experience unrealistic present india needs develop strategies technologies source water pollution control industrial municipal environmental remediation embrace country specific need battle water resource problem study aimed comparative variation physico chemical properties heavy metals estimation drinking water samples collected different districts jharkhand india water quality index total number water samples collected different sources like hand pumps wells taps gross appearance total hardness total alkalinity tds heavy metals like analyzed results physico chemical parameters heavy metals estimation water samples found within acceptable limit per samples district dhanbad bokaro ramgarh hazaribag area giridih showed slight variation wqi value indicates quality water five districts poor ground water use drinking purpose requires treatment including removal iron softening
objective aim study compare prevalence asca spondyloarthrites spa patients investigate association asca status disease phenotype methods performed case control study including spa individuals fulfilling essg spa criteria following data collected analysis gender age disease duration clinical associated features spa treatments hlab asca status control group patients without spa also analyzed results total patients spa control patients studied median age spa patients male patients hlab iqr years old disease duration iqr months inflammatory bowel diseases observed spa patients asca positivity significantly higher spa patients control patients igg iga multivariate analysis revealed asca positivity associated peripheral involvement presence ibd past present history uveitis arthritis conclusion results provided evidence spa patients increased prevalence asca asca positivity might associated particular phenotype notably peripheral involvement uveitis published elsevier masson sas behalf societe francaise rhumatologie
contact problem exists widely mechanical engineering civil engineering manufacturing engineering etc extremely complicated nonlinear problem usually solved finite element method unlike traditional finite element method necessary set contact elements contact analysis different types contact elements goodman joint elements cover surface contacted bodies zero thickness widely used however debates characteristics attached elements goodman joint elements paper studies type matching meshing attached elements results paper would helpful finite element contact analysis
energy consumption commercial buildings represents around total energy produced north america total rated power small dry type transformers dtt installed within typical large office building lob mva minimum typically dtt energized loaded rated power running hours year efficiency values paper presents outcomes demonstration project considered smart configurations dtt alternate existing methods project intended become one enablers leed volume program design construction program operation maintenance launched usa canada green building councils usgbc cgbc design proposed paper box approach change traditional design power grids lob work demonstrated power flow within lob grid optimized dynamic reconfiguration power grid topology static dynamic loading dtts leading improvement dtt performance reducing dtt power demand lob smart grid adapt optimum power flow human intervention paper also proposes new concepts designing distribution power grid within lob result reduction capital costs caper increase operational energy savings reduce maintenance costs opex
pond aeration systems developed sustain large quantities fish biomass materials study importance functions aeration examined prototype paddle wheel aerator developed main features paddle wheel aerator electric motor used prime mover one horse power capacity paddle hubs six paddles mounted shaft made stainless steel brass materials aeration experiment conducted water basin made plastic paddle wheel aerator performance evaluation conducted using unsteady state test physico chemical properties water sampled tested ponds determined accordance american public health association standards apha performance test carried showed overall oxygen transfer efficient observed high standard oxygen transfer rate sotr standard aerator efficiency sae ranged respectively paddle wheel aerator improved water quality addition oxygen leading appreciable increase fish stock density major setback low income fish farmer nigeria
using regression discontinuity design show personal experience public health insurance programs exerts causal influence attitudes toward medicare affordable care act however argue conditional dynamics policy feedback effects differ standard models opinion formation change specifically find personal experience shape preferences among whose partisanship might otherwise make resistant elite messaging case support health policy find effects public programs pronounced among republicans addition find effects personal experience unlike attempts shape attitudes elite political messaging concentrated among low information voters might otherwise attuned political environment
series macrocyclic analogues designed synthesized based cocrystal structure small molecule plasma kallikrein pkal inhibitor pkal protease domain led discovery potent macrocyclic pkal inhibitor one olefinic isomer olefinic isomer
cancer second leading cause mortality morbidity behind heart disease necessitating urgent development chemo therapeutic interventions stem growing burden cancer cases cancer death plants represent credible source promising drug leads regard long history proven use indigenous treatment cancer study therefore investigated anacardium occidentale one plants nigerian traditional medicine formulation commonly used manage cancerous diseases cytotoxic activity bioassay guided fractionation spectroscopy alamar blue fluorescence based viability assay cultured hela cells microscopy used four compounds zoapatanolide agathisflavone bis dimethoxy methoxycarbonylphenyl ethane anacardicin methyl gallate isolated potent zoapatanolide value viability assay gain insight likely molecular basis observed cytotoxic effects autodock vina binding free energies isolated compounds seven molecular targets implicated cancer development mapk mapk mapk mapi mapk mapk vegf calculated pearson correlation coefficients obtained experimentally determined alamar blue viability assay compounds potent standard anticancer compound doxorubicin results provide reasonable evidence plant species contains compounds cytotoxic activity study provides evidence plant used ethnobotanically anticancer herbal formulations justifies investigating nigerian medicinal plants highlighted recent ethnobotanical surveys elsevier ltd rights reserved
helicases play critical role processes replication recombination unwinding double stranded dna mutations genes therefore devastating biological consequences humans mutations genes three members recq family helicases blm wrn recq give rise three strikingly distinctive clinical phenotypes bloom syndrome werner syndrome rothmund thomson syndrome respectively however molecular basis varying phenotypic outcomes unclear part full mechanistic description helicase activity lacking helicase core domains highly conserved postulated functional differences among family members might explained significant differences terminal domains domains poorly characterized help fill gap describe bioinformatics biochemical structural data three vertebrate blm proteins pair high resolution crystal structures saxs analysis describe internal highly conserved sequence term dimerization helical bundle terminal domain dhbn show despite terminal domain loosely structured potentially lacking defined three dimensional structure general dhbn exists dimeric structure required higher order oligomer assembly interestingly unwinding amplitude rate decrease blm assembled dimer hexamer also stable dhbn dimer dissociated upon atp hydrolysis thus structural biochemical characterizations terminal domains provide new insights terminal domain affects structural functional organization full blm molecule
two studies tested model whereby identification minority group predicted impact acculturation preferences turn proposed impact involvement intragroup friendships minority members intergroup friendships majority members stress experienced minority members direct path minority identification stress also included model model tested using structural equation modelling survey data collected muslim women somali minority members britain results supported predictions revealed identification associated culture maintenance preference less culture adoption preference culture maintenance preference associated involvement intragroup friendships culture adoption preference associated involvement intergroup friendships increased stress practical applications findings discussed
aimto evaluate impact living arrangements mortality functional decline among older patients dementia cognitive impairment discharge geriatric evaluation management unit gemu taiwan methodsthe present retrospective cohort study used data veteran affairs comprehensive geriatric assessment january may analysis data patients aged years older dementia cognitive impairment admission gemu taipei veterans general hospital study period retried study veteran affairs comprehensive geriatric assessment included demographic characteristics clinical frailty scale braden scale thomas risk assessment tool falling elderly inpatients scale cumulative illness rating scale geriatrics barthel index instrumental activities daily living mini mental state examination geriatric depression scale mini nutritional assessment short form well common geriatric syndromes patients categorized home care group institutional care group based living arrangement gemu admissions six month mortality decline barthel index defined adverse clinical outcomes resultsoverall data patients used analysis baseline comparisons showed institutional care group likely unmarried lower education lower risk falls less polypharmacy likely experience functional decline follow home care group multivariate logistic regression showed male higher cumulative illness rating scale geriatrics score associated mortality whereas institutional care group lower braden scale protective mortality however institutional care group independently associated functional decline follow period conclusionsinstitutional care associated lower month mortality risk patients dementia cognitive impairment discharge gemu group likely experience functional decline prospective study required clarify clinical impact living arrangements long term outcomes people dementia cognitive impairment admitted acute hospitals geriatr gerontol int suppl
phase locked loop pll based method determining audio authenticity proposed work assuming power grid signal embedded audio signal certain pre processing techniques applied order obtain electrical network frequency enf pll used estimate time varying phase enf signal postprocessing carried improve system performance finally automatic decision authenticity audio conducted quantifying frequency variations vco output performance proposed method evaluated digitally edited original audio signals promising results achieving accuracy
effective rainfall used paddy fields farmers current water management practices monitored period southern korea two paddy fields studied area respectively composed several paddy plots separated irrigation canals drains site effective rainfall ranged averaged site effective rainfall ranged averaged approximately rainfall respectively used crop growing paddy fields amounts less recommended rainwater harvesting criteria korea since height bund paddy plot approximately plots sufficient space hold rainfall despite field data indicate rainfall used efficiently study confirms farmers little incentive use rainfall effectively rice paddy culture use irrigation water charge measures water pricing incentives rainwater harvesting improvement drainage facilities monitoring water use practices need adopted improve water management efficiency copyright john wiley sons ltd
background objectivefrailty age related accumulation deficits decrease ability respond biological stress patients fibrotic interstitial lung disease ild may frail due consequences ild age morbidities adverse effects pharmacotherapies objective study examine prevalence predictors frailty fibrotic ild methodsfibrotic ild patients recruited specialized clinic patients ild secondary systemic disease excluded frailty determined using frailty index based presence absence multiple deficits including morbidities symptoms functional limitations frailty index based proportion deficits present frailty defined score cronbach alpha used estimate internal consistency frailty index dyspnoea measured using university california san diego shortness breath questionnaire multivariate analysis used determine independent predictors frailty resultsthe definition frailty met patients cronbach alpha frailty index frailty index associated forced vital capacity fvc forced expiratory volume fev diffusion capacity lung carbon monoxide dlco ild gender age physiology gap index composite physiologic index dyspnoea score dyspnoea severity strongest unadjusted predictor independent predictor frailty index increase frailty index per point increase dyspnoea score conclusionfrailty highly prevalent strongly independently associated dyspnoea severity demonstrating dyspnoea important determinant frailty pulmonary function fibrotic interstitial lung disease ild patients recruited specialized clinic show frailty highly prevalent strongly independently associated dyspnoea severity findings suggest frailty important feature fibrotic ild warrants study
background fecal microbiota transplantation fmt represents new therapeutic option studied two randomized controlled trials ulcerative colitis patients study aimed identify patients views use novel therapeutic approach methods using anonymous questionnaire obtained data inflammatory bowel disease ibd patients knowledge willingness undergo fmt results large proportion ibd patients unaware fmt therapeutic option clostridium difficile infection potentially ibd responders preferred fmt study new medication although difference significant preferred way transplantation colonoscopy preferred family member donor fear procedure mentioned fear infectious diseases expressed disgust knowledge successful fmt treatment patients important responders discussion specialist would likely change opinion fmt conclusion fmt represents therapeutic procedure interest ibd patients fmt receiving increasing interest alternative treatment ibd studies fmt ibd carried important learn knowledge attitude preferences patients provide better education patients topic however reservations fact data benefits fmt ibd controversial several limitations exist use fmt ibd copyright wolters kluwer health inc rights reserved
anaplastic lymphoma kinase alk receptor tyrosine kinase associated alcohol dependence humans behavioral responses ethanol mice characterize ability alk control ethanol consumption treated mice alk inhibitors tae alectinib testing binge like drinking using drinking dark protocol mice treated alk inhibitors drank less ethanol controls addition tae treatment abolished ethanol conditioned place preference indicating alk regulates rewarding properties ethanol ventral tegmental area vta key brain region involved rewarding effects ethanol determined alk expression vta important binge like ethanol consumption mice expressing short hairpin ribonucleic acid targeting alk vta drank less ethanol compared controls alk expressed dopamine neurons vta suggesting alk might regulate firing properties extracellular recordings putative neurons vta slices demonstrated alk inhibition affect ability ethanol stimulate inhibit firing neurons however inhibiting alk attenuated time dependent reversal inhibition produced moderate concentrations suggesting alk affects autoreceptor desensitization altered desensitization changes firing neurons predicted affect levels alcohol drinking data support possibility alk might novel target pharmacotherapy reducing excessive alcohol consumption
work aimed develop novel epoxy modified tung oil waterborne insulation varnish blocked hexamethylene diisocyanate curing agent diels alder reaction tung oil maleic anhydride ring opening esterification reaction epoxy resin confirmed conversion rate epoxy explored function reaction time temperature effects epoxy resin content thermal stability water absorption insulation properties insulation strength volume resistivity surface resistivity films investigated resistances films salted water evaluated increase epoxy resin contents could improve thermal stability insulation properties films decreased water adsorption films epoxy resin content reached water solubility resin became poor immersed nacl solution electrical insulation strength films lower dry state decreased immersed time prolonged particular electrical insulation strength loss films increased significantly epoxy resin content furthermore increase epoxy resin content could improve hardness adhesion films flexibility films became worse basis experimental epoxy resin content appropriate prepare waterborne epoxy modified tung oil resin resulting varnish may potential immersing insulation varnish spindle electric motor wiley periodicals inc appl polym sci
background randomized prospective study designed assess whether piperacillin tazobactam pipc taz effective meropenem mepm first line antibiotic treatment febrile neutropenia procedure episodes randomly assigned receive either pipc taz per day three doses div maximum per day mepm per day three doses div maximum per day clinical responses evaluated div results total febrile episodes patients females males median age years range included trial blood cultures positive episodes regarding responses treatment success rates pipc taz mepm groups similar even patients restricted bacteremia mortality rates significantly differ two groups conclusion pipc taz mepm appeared equally efficacious safe carbapenems broadly used treat however may increase prevalence drug resistant bacteria regard treatment using pipc taz beneficial
battery cost one crucial parameters affecting high deployment electric vehicles evs negatively accurate state health soh estimation plays important role reducing total ownership cost availability safety battery avoiding early disposal batteries decreasing unexpected failures circuit design soh estimation battery system bases selected battery cells integration evs presented paper prototype microcontroller developed used accelerated aging tests battery system data collected lab tests utilized simulate real battery system results accelerated aging tests simulation presented paper paper also discusses identification best number battery cells selected soh estimation test addition different application options presented approach batteries discussed paper elsevier ltd rights reserved
altered reward reactivity potential risk endophenotype eating disorders eds aim study examine reward reactivity female twins eds compare twin control group sample twins met lifetime dsm criteria anorexia nervosa bulimic disorders unaffected cotwins control twins administered measures assessing reward reactivity including game dice task behavioural inhibition activation bis bas scales appetitive motivation scale ams within pair correlations monozygotic dizygotic twins calculated generalised estimating equations compared probands non cotwins controls bas ams reduced eds negatively associated restrictive symptoms addition monozygotic twins pairs demonstrated significant within pair similarity bas ams conversely less evidence support bis risky decision making measured game dice task endophenotype eds copyright john wiley sons ltd eating disorders association
beta conglycinin beta well known inducing intestinal allergies dysfunction neonates young pigs however underlying mechanisms largely unknown study clarify role autophagy beta induced cytotoxicity investigated effects beta cell viability autophagy activity porcine enterocytes ipec cells results indicated cell viability decreased increasing levels beta beta treatment enhanced egfp puncta per cells latter increased ipec cells cultured bafilomycin conclude beta enhances autophagy activity enterocytes
offering safe relatively inexpensive reproducible teaching environment exploring phenomena interactive course modules applications special interest education engineering physics students usually difficulty understating topic electrical circuits limited evidence literature supporting premise utilizing interactive course modules improves student learning topic electric circuits understanding topic electric circuits important high school students plan enter engineering programs universities turkey since topic covered university entrance exam conducted nationwide moreover topic electric circuits taught many engineering programs study explored question whether achievement students using interactive course module different achievement students taught didactic teaching along traditional teaching tools fifty high school students pre test post test control group research design used investigate research question findings revealed utilizing interactive course modules teach topic electric circuits found improve students learning better teaching content didactic teaching along traditional teaching tools research undertaken compare use simulations real laboratory equipment
internet playing important role today society wireless network mobile devices becoming part lives significant learn information users network usage network researchers managers fixed wireless network previous methods user characterizing network usage mostly based tcp traffic study facing large amount users raw packet capturing storing would difficult also previous methods researched fixed network wireless network comparative study hardly seen paper measured large scale fixed wireless network campus via dhcp analysis analyzed user behavior distribution user online time user count join leave time stamps also studied users operating systems introducing dhcp fingerprinting found interesting results revealed trend mobile network challenges might brought
consider image motion stabilization system embedded space telescope scanning optoelectronic observation terrestrial targets developed model system presented taking account physical hysteresis piezoceramic driver time delay forming digital control presented elaborated algorithms discrete filtering digital control obtained results analysis image motion velocity oscillations telescope focal plane also methods terrestrial flight verification system
context exception handling become popular major programming languages including ada java since exception handling introduced programming languages various kinds exception analyses analyze exceptional behavior programs statically dynamically exception analyses also applied various software engineering tasks testing slicing verification visualization objective paper aims providing comprehensive view studies exception analysis conducted review exception analysis identify classify studies method referred literature review method selected comprehensive set papers exception analysis papers published journals conference proceedings categorization classification done according research questions regarding analyze analyze analyze applications exception analysis results first identify three categories static exception analysis two categories dynamic exception analysis together main applications exception analyses also discuss main concepts research methods used major contributions studies exception analysis conclusion provided comprehensive review exception analysis best knowledge first comprehensive review exception analysis work would interesting see existing exception analysis techniques reviewed paper applied programming languages exception handling mechanism scala eiffel rarely explored elsevier rights reserved
although association media violence exposure mve physical aggression well studied studies examined link mve subtypes aggression purpose study examine relation mve reactive proactive subtypes relational aggression six hundred forty one third fifth grade students reported exposure media violence assessed peers teachers reactive proactive subtypes assessed teacher reports findings revealed significant positive association mve overall relation stronger girls boys predicting functional subtypes aggression higher mve associated lower reactive higher proactive higher reactive mve unrelated proactive implications findings future research discussed
paper presents novel online tool robust pid controller design robcont enables design robust pid controllers analyze stability closed loop control performance advanced way tool extension modular system webpiddesign complex framework provides features system identification pid controller design evaluation control quality robcont extends possibilities framework control design tasks focused systems interval uncertainties tool allows user perform step step procedure system definition open loop analysis selection robust controller closed loop simulation evaluation control quality controller selection based neimark partition method kharitonov plant theorem robcont extends also features webpiddesign enables perform polynomial approximation time delay systems paper also contains case study real laboratory process common robcont usage procedure illustrated presented tool mainly intended education purposes field automatic control
concept autonomous farming concerns automatic agricultural machines operating safely efficiently without human intervention order ensure safe autonomous operation real time risk detection avoidance must undertaken paper presents flexible vehicle mounted sensor system recording positional imaging data total six sensors full procedure calibrating registering sensors authentic data recorded case study grass harvesting human safety paper incorporates parts iso emerging standard safety highly automated machinery agriculture related human detection safety case study investigates four different sensing technologies intended dataset validate human safety human detection system grass harvesting study presents common algorithms able detect humans struggle handle lying occluded humans high grass
objective aim study evaluate association thyroid function abnormalities breast cancer particular prognostic markers breast cancer subjects methods baseline levels thyrotropin free triiodothyronine free thyroxine thyroid autoantibodies measured women primary breast cancer women benign breast disease women atypical ductal hyperplasia baseline levels compared healthy women normal mammography last years results significant associations history thyroid disease breast cancer mean baseline levels triiodothyronine thyrotropin differ significantly compared groups mean baseline levels free thyroxine found significantly higher breast cancer group even adjusting thyroid replacement therapy presence thyroid antibodies differ significantly compared groups subgroup analysis breast cancer cases thyroid disease particularly hypothyroidism significantly lower incidence lymph node metastases compared breast cancer cases without thyroid disease conclusions data confirmed proliferative effect thyroid hormones breast cells previously shown vitro additionally thyroid disease particularly hypothyroid function appeared associated lower incidence lymph node metastases studies determine prognostic role thyroid hormones breast cancer warranted
aim article explore tendencies stereotype minority ethnic groups intersect lay discourses ways reproduce cultural prejudices reinforce inequalities access services health outcomes drawing upon black feminist cultural studies literature present theoretical examination stereotypes black woman mammy matriarch suggest influence two images central understanding normalisation larger black female body within african caribbean communities representation excess weight contradicts mainstream negative discourses large bodies view form moral weakness seeking stimulate reflection unacknowledged stereotypes may shape clinical encounters propose black women perception strength tied racial images mammy matriarch may influence health services advice sought offered particular significance relation body weight weight management talked primary care based interactions support black women offered argue unintentional bias tangible impacts health outcomes black women possibly minority ethnic groups
battery based energy storage systems cell equalizer essential improve battery life cycle maximize capacity utilization however conventional cell equalizers require long durations accomplish cell balancing due power rating output current limitation high power application green building renewable energy electrical vehicles fast equalizing vital paper current fed full bridge topology proposed targeted fast cell equalizing compared conventional technology proposed topology applied high power application reduce equalizing time furthermore proposed topology requires fewer components cell equalizing algorithm based automatically switched maximum current voltage control introduced ensure battery cells work safely equalizing process minimize equalizing time proposed cell equalizer verified simulation experiment
precision low voltage rectifiers important building blocks analog signal processing paper full wave rectifier based two bipolar memristive systems threshold one inverter presented traditional approach based opamp diodes exhibits undesirable effects caused diode commutations opamp imperfections pspice simulation results included
paper attempt made extend application recently proposed flexural constitutive model short long term deformational analysis flexural partially prestressed concrete members proposed calculation technique applied simple engineering technique based principles strength materials layered approach effect tension stiffening non linear time effects creep shrinkage taken account effective modulus method used modeling long term deformations short long term deformation curvatures prediction results tested experimental data partially prestressed concrete beams reported literature
background aims mediterranean diet associated reduced morbidity cardiovascular diseases general population aim study assess whether different degrees adherence associated cardiometabolic risk peri menopausal women methods results cross sectional study included peri menopausalwomen participating flamenco project validated questionnaires used assess menopause healthrelated quality life degree adherence low medium high following cardiometabolic risk factors assessed fat mass percentage waist circumference blood pressure resting heart rate plasma markers total cholesterol high low density lipoprotein cholesterol hdl ldl respectively total cholesterol hdl ratio triglycerides reactive protein fasting glucose physical activity levels smoking status degree adherence among study sample low medium high adherence respectively controlling potential confounders women high adherence showed lower plasma total cholesterol resting heart rate ldl triglycerides reactive protein compared low adherence likewisewomen high adherence mdshowed lower total cholesterol hdl ratio compared medium adherence high adherence group also showed lower clustered cardiometabolic risk moreover analysing specificmd components whole grain cereals pulses red wine consumption inversely associated clustered cardiometabolic risk conclusion present findings suggest high medium adherence associated cardioprotective effect peri menopausal women low percentage sample showed high adherence future research aimed increasing adherence dietary pattern better cardiometabolic status peri menopause warranted italian society diabetology italian society study atherosclerosis italian society human nutrition department clinical medicine surgery federico university published elsevier rights reserved
candida dubliniensis uncommon species candida implicated fungal pneumonia rarely present case year old man laryngeal cancer undergoing chemotherapy broad spectrum antibiotics tuberculosis therapy blood endotracheal cultures positive dubliniensis subsequent autopsy performed postmortem lung cultures positive dubliniensis lung histopathology demonstrating invasive fungal infection molecular analysis lung tissue confirmed identity fungi dubliniensis since discovery pathogen oral cavities hiv positive patients dubliniensis identified wide spectrum clinical scenarios anatomic locations manifests rarely pneumonia report represents novel case dubliniensis pneumonia confirmed culture histopathology molecular identification
elevations impulsive behavior observed number serious mental illnesses phenomena lead harmful behaviors including violence thus represent serious public health concern violence often reason psychiatric hospitalization often leads prolonged hospital stays suffering patients victims increased stigmatization despite attention paid violence little understood neural basis schizophrenia psychological level aggression schizophrenia primarily attributed psychotic symptoms desires instrumental gain impulsive responses perceived personal slights often multiple attributions coexist single aggressive incident review discuss neural circuitry associated impulsivity aggression schizophrenia emphasis implications treatment impulsivity appears account great deal aggression schizophrenia especially inpatient settings urgency defined impulsivity context strong emotion primary focus article elevated several psychiatric disorders schizophrenia related aggression many studies implicated dysfunctional frontotemporal circuitry impulsivity aggression schizophrenia pharmacological treatments may act via circuitry reduce urgency aggressive behaviors however mechanistic studies critically needed recent studies point toward manipulable neurobehavioral targets suggest cognitive pharmacological neuromodulatory neurofeedback treatment approaches developed ameliorate urgency aggression schizophrenia hoped approaches improve treatment efficacy
physiological developmental effects thyroid hormones mainly due control gene expression interaction nuclear receptors understand role thyroid hormones cerebral cortex development knowledge genes regulated specific stages development required laboratory previously identified genes regulated primary cerebrocortical cells culture comparing data transcriptomics purified cell types developing cortex cellular targets identified addition many genes regulated transcriptionally defined roles cortex development role derived review analyzes specific roles regulated genes different stages cortex development within physiological frame developmental changes thyroid hormones receptor concentrations human cerebral cortex fetal development data indicate increase sensitivity second trimester fetal development main cellular targets appear cajal retzius subplate neurons hand regulates transcriptionally genes encoding extracellular matrix proteins involved cell migration control diverse signaling pathways
research question scholars paid little attention consumer response termination sponsorship purpose study examine reaction fans professional cycling team sponsorship terminating ultimately led team disbanding research methods research purpose pursued digital ethnography via message boards weblog examining case basque professional cycling fans comments analysed understand fans reaction cessation euskaltel euskadi basque professional cycling team sponsor euskaltel exited partnership results findings fan reaction euskaltel ending sponsorship somewhat paradoxical terminated sponsorship ultimately led team disbanding yet fans appeared appreciative euskaltel continued celebrate team corporate sponsor colour mourned end euskaltel euskadi questioned future basque cycling reaction made logical understanding long term duration partnership euskaltel support team nearly two decades led intermeshing team sponsor thus avoiding negative sentiment implications study makes meaningful contribution sponsorship literature particularly sponsorship termination study one first examine consumer response sponsorship termination real world setting suggests potential legacy effect long term sponsorship fan reaction long term sponsorship terminating may negative especially fans understand sponsor contribution time
purpose solid organ tumor incidences higher solid organ transplant patients general population aim study analyze solid organ tumor frequency characteristics population lung transplant patients provide brief review literature methods retrospective analysis conducted patients underwent lung transplant lung transplant program university hospital siena italy patients demographics pretransplant characteristics immunosuppressive therapy infectious factors recorded results nine patients median age years range cohort developed solid organ tumor patients experienced nonmelanoma skin cancer others diagnosed lung cancer breast cancer colon rectal cancer median time transplantation tumor diagnosis days range differences pretransplant characteristics immunosuppressive therapy infectious factors found patients developed solid organ tumors conclusions present study confirmed novo malignancies major issue lung transplant patients particular skin lung cancers demonstrated higher incidence rate oncologic treatment patients complex requiring close collaboration transplant team oncologist strict screening programs key factors early diagnosis allow prompt treatment resulting better outcome
recent progress regenerative medicine suggested mesenchymal stem cell msc based therapy novel potential cure diabetes betatrophin newly identified hormone increase production expansion insulin secreting cells administered mice study evaluated effect betatrophin overexpression human adipose derived mscs admscs vitro experiments well following transplantation mice streptozotocin stz induced diabetes overexpression betatrophin affect admscs terms proliferation differentiation morphology however culture human islets admscs overexpressing betatrophin admscs bet induced islet proliferation cell specific transcription factor expression islet production insulin stimulation glucose kcl arg addition admscs bet enhanced anti inflammatory anti apoptotic effects cultured islets compared admscs cultured alone mice stz induced diabetes transplantation admscs bet ameliorated hyperglycemia weight loss associated stz induced diabetes admscs bet also significantly enhanced ratio cells per islet compared transplantation admscs alone thus study demonstrates novel strategy inducing cell regeneration admscs bet may replace insulin injections increasing number endogenous insulin producing cells patients diabetes combined strategy admsc transplantation gene therapy may prove useful therapy treatment diabetes
signal transient current boosting stcb circuit proposed applied single stage amplifier driving large capacitive loads proposed stcb circuit provides gain bandwidth product gbw extension slew rate improvement gain enhancement amplifier slight alterations frequency response transient response single stage amplifier driving large capacitive loads chip capacitor resistor required stcb amplifier fabricated commercial cmos technology active chip area supply current consumption capacitive load ranges measured results similar load show small signal figure merit foms gbw power large signal large figure merit foml power mhz respectively correspond improvements times times respectively prior art achieved phase margin gain margin degrees respectively
bearingless permanent magnet synchronous motors bpmsms received attention past decades realize high performance control rotation levitation first need obtain accurate suspension force model bpmsm work different conventional suspension force models modeling scheme suspension force bpmsm presented taking account rotor eccentricity maxwell stress tensor modeling scheme theoretical value suspension force model compared two dimensional finite element analysis calculation results reveal theoretical value closely agree computed one furthermore digital control system devised taking advantage tmsf test platform experiments set accordance corresponding findings experiments rotor stabilization magnetic levitation achieved results lay theoretical experimental foundation study bpmsm
allergic hypersensitivity reactions anaphylaxis asthma exacerbations may occur air travel although exact incidence flight asthma allergic emergencies known concerns subject received attention warrants need provide passengers risk airlines necessary measures prevent manage emergencies review epidemiology management approaches prevention allergic asthma emergencies air travel presented goal increasing awareness important potentially preventable medical events
examined relationships alzheimer disease neuropathologic change adnc lewy body disease lbd vascular brain injury vbi large autopsy samples findings may differ study populations data came alzheimer disease centers contributing national alzheimer coordinating center population based adult changes thought study regardless study population participants adnc cooccurring lbd vbi majority clinical dementia diagnosis prior death overlap pathologies similar studies especially standardizing distribution age dementia status adult changes thought population lbd vbi positively associated adnc studies interestingly cortical lbd common intermediate adnc compared low high adnc especially national alzheimer coordinating center high prevalence occurring neuropathologies among older adults dementia implications accurate diagnosis dementia etiologies development disease modifying strategies elsevier inc rights reserved
follow celiac disease challenging due scarcity published data lack standardized evidence based protocols worldwide frequency methods follow appear heavily influenced expert opinions individual physicians assess children aim review summarize available studies follow children conducted literature search use pubmed medline embase december terms relevant review including follow dietary adherence dietary compliance nutrition comorbidities complications quality life aims follow follows ensure strict adherence gluten free diet ensure nutritional adequacy improve quality life prevent disease complications correct evaluation children follow clinical biochemical evaluation necessary regular basis advisable assess compliance nutrition comorbidities possible complications year referral center laboratory tests might useful thorough evaluation patient rule micronutrient deficiency full blood count ferritin folic acid vitamin vitamin possible cardiovascular risk factors glucose ldl cholesterol triglycerides biochemical evaluation essential clinical problems customized basis specific clinical suspicion associated autoimmune thyroiditis also screened yearly measuring thyroid stimulating hormone thyroid autoantibody concentrations regardless symptoms hypothyroidism often subtle methods early treatment available desirable although evidence based recommendations follow pediatric patients yet established advise yearly follow visit safest approach
simulation well established effective approach development fuel efficient low emissions vehicles highway highway applications simulation highway automotive vehicles widely reported literature whereas research relating non automotive highway vehicles relatively sparse review paper focuses challenges simulating vehicles discusses differences approach drive cycle testing experimental validation vehicle simulations particular inner city diesel electric hybrid bus ice internal combustion engine powered forklift truck used case studies computer prediction fuel consumption emissions automotive vehicles standardised drive cycles well established commercial software packages avl cruise specifically developed purpose vehicles considered review paper present new challenges simulation drive cycle testing perspectives example case forklift truck drive cycles involve reversing elements variable mass lifting operations specify precise velocity time profile particular difficulties associated prediction productivity maximum rate completing series defined operations discussed case hybrid bus standardised drive cycles unrepresentative real life use alternative approaches required development efficient low emission vehicles two simulation approaches reviewed adaptation standard automotive vehicle simulation package development bespoke models using packages matlab simulink elsevier ltd rights reserved
drilling fluid rheological properties monitored frequently drilling operations prevent problems related change properties properties yield point plastic viscosity apparent viscosity crucial evaluate drilling fluid efficiency cleaning well properties measured twice day marsh funnel viscosity solid content drilling fluid density measured every min previous models introduced predict apparent viscosity drilling fluid marsh funnel viscosity large errors paper first time introduced new model predict drilling fluid rheological properties marsh funnel viscosity solid content density measurements real time developed mathematical model obtained weights biases transfer functions used artificial neural networks anns anns black box converted white box obtain visible mathematical model used predict drilling fluid rheological properties using marsh funnel viscosity solid content density based data points collected field measurements actual drilling fluid samples used model training testing viscometer readings rpm predicted using visible mathematical model anns rheological parameters yield point plastic viscosity apparent viscosity consistency index determined viscometer readings rpm predicted rheological parameters compared measured ones field match good average absolute error various parameters ranges maximum compared used previously developed correlations developed model robust technique tool used predict real time drilling fluid rheological parameters essential drilling hydraulics design also predict performance drilling fluid efficient performance drilling fluids depends quality drilling fluid needs monitored frequently new model process achievable elsevier rights reserved
multiple sclerosis neuroinflammatory demyelinating disease cns fibrinogen deposition sites blood brain barrier breakdown prominent feature neuroinflammatory disease contributes disease severity plasminogen primary fibrinolytic enzyme also modifies inflammatory processes used murine model experimental autoimmune encephalomyelitis eae evaluate hypothesis loss plasminogen would exacerbate neuroinflammatory disease however contrary initial expectations eae challenged plasminogen deficient plg mice developed significantly delayed disease onset reduced disease severity compared wild type plg mice similarly pharmacologic inhibition plasmin activation tranexamic acid also delayed disease onset cell response immunization similar genotypes suggesting contribution plasminogen downstream cell response spinal cords eae challenged plg mice demonstrated significantly decreased demyelination microglial macrophage accumulation compared plg mice although fibrinogen deficient mice mice combined deficiencies plasminogen fibrinogen decreased eae severity exhibit delay eae disease onset seen mice plasminogen deficiency alone together data suggest plasminogen plasmin mediated fibrinolysis key modifier onset neuroinflammatory demyelination
alternative process anaerobic wastewater treatment methane recovery elongate carbon chain volatile fatty acids vfas formation medium chain carboxylic acids mccas caproic acid higher monetary value potential electron donor glycerol surplus byproduct rapid growth waste derived biodiesel industry current approach industrial chemical propanediol pdo produced crude glycerol along formation soluble byproducts including ethanol volatile fatty acids vfas necessitates significant amount energy input separation purification circumvent energy sink requirement upcycle wastewater treatment process biodiesel industry highly beneficial produce valuable secondary product byproducts pioneer study reports thermodynamic physiological insights gained production pdo caproate glycerol thermodynamics analysis demonstrated higher range favorable either glycerol ethanol acting electron donor whereas high partial pressure atm low advantageous caproate formation hydrogen glycerol acetate molar ratio physiological experiments achieved production pdo caproate however caproate yield low found kinetic limited caproate formation significantly increased intermediate ethanol addition optimal mono caproate formation obtained ethanol acetate molar ratio synergistic relationship evinced microbial characterization resulting clostridium kluyveri bacteria function converting glycerol vfas study demonstrates sufficient ethanol produced intermediate capable enhancing caproate formation synergistic pathway along pdo knowledge gleaned paves new avenues biodiesel industry upcycling byproduct crude glycerol pdo caproate elsevier ltd rights reserved
major electrophysiological mechanisms underlying atrial fibrillation described around years ago important recent improvements biophysical theory mapping cardiac electric activity noninvasive imaging generated significant new controversial ideas discuss ideas evidence based significance arrhythmia research therapy common underlying molecular mechanisms may allow therapeutic improvements even without definitive resolution electric processes maintain atrial fibrillation
retrospective cohort study identify rates predictors outcomes health care associated bloodstream infections bsi among children solid tumors lymphoma lymphoid leukemia myeloid leukemia study population included children years old pediatric hospital new york city total bsi cases identified using multivariable logistic regression modeling children hematologic diagnosis lymphoma lymphoid leukemia myeloid leukemia greater risk bsi solid tumor diagnosis values odds mortality patients bsi confidence interval times without bsi although malignancy type identified risk factor bsi significant difference overall mortality bsi tumor type
research focused project management associated new product development aeronautic industry highlighting particular importance efficiency manufacturing processes analysis based questionnaire cases spread throughout pmbok answered professionals extensive experience aeronautic industry data treated statistically using techniques multidimensional scaling principal component analysis taking advantage exploratory factor analysis single factor results showed ten important processes associated following themes develop project team control quality determine budget conduct acquisitions control risk identify risks plan cost management manage project team plan management acquisitions plan risk management despite good overall results efficiency levels previous cases also note performance improvement possibilities studied company
widespread utilization multicore processors operating systems face new challenges scalability lock mechanism used current monolithic oss makes critical modules encounter performance bottlenecks caused lock contention contention linux process lifecycle management results process creation execution termination cet scaling poorly core count increasing differing centralized fashion linux paper presents distributed process management model dpmm micro kernel better scalability kernel functions distributed message passing servers running different cores dpmm splits shared data including process control blocks pcbs page pools buffer caches cooperating servers actions including pcb creation deletion page allocation freeing executable loading scheduling parallelized without locking micro benchmarks show dpmm achieves nearly linear performance growth process cet outperforms linux minix core machine
using large dataset obtained paipaidai online peer peer lending platform china examine whether credit officers mood affects efficiency credit approval perspective individual decision making refering studies psychology financial economics employ season temperature weather mood proxies control variables related quality loan study credit approval behavior different mood conditions results suggest efficiency credit approval individual credit officers significantly correlated mood positive mood improves efficiency negative mood reduces specifically loans examined better mood conditions spring comfortable temperatures sunny days significantly higher probability approval lower probability default approved examined poorer mood conditions show lower probability approval higher probability default approved effect mood even stronger loan application complex atypical unusual evaluate moreover investor sentiment denoted closed end fund premiums effect credit approval well
background despite increasing evidence relationship exposure phthalates bisphenol allergies asthma reports atopic dermatitis chemicals assessed association symptoms exposure phthalates bisphenol children methods surveyed boys age years day care center seoul may april symptoms recorded using daily symptom diary collected series pooled urine twice day morning afternoon working days measured concentrations mono ethyl oxohexyl phthalate oxo mehp mono ethyl hydroxyhexyl phthalate mehp mono isobutyl phthalate mnbp bisphenol glucuronide bpag pooled urine logistic regression used statistical analysis results phthalate metabolite levels higher morning afternoon seasonal variation levels phthalates bisphenol metabolites levels mehp mnbp bpag highest summer manifestation symptoms associated increase urinary levels mnbp adjusted odds ratio aor per mnbp bpag aor per bpag day levels mnbp bpag previous day increased symptoms aor mnbp aor bpag conclusion results suggest exposure phthalates bisphenol associated aggravation symptoms children
need novel automated mosquito perception classification method becoming increasingly essential recent years steeply increasing number mosquito borne diseases associated casualties exist remote sensing gis based methods mapping potential mosquito inhabitants locations prone mosquito borne diseases methods generally account species wise identification mosquitoes closed perimeter regions traditional methods mosquito classification involve highly manual processes requiring tedious sample collection supervised laboratory analysis research work present design experimental validation automated vision based mosquito classification module deploy closed perimeter mosquito inhabitants module capable identifying mosquitoes bugs bees flies extracting morphological features followed support vector machine based classification addition paper presents results three variants support vector machine classifier context mosquito classification problem vision based approach mosquito classification problem presents efficient alternative conventional methods mosquito surveillance mapping sample image collection experimental results involving classification mosquitoes predefined set bugs using multiple classification strategies demonstrate efficacy validity proposed approach maximum recall
review examines prospects decentralised hybrid rainwater greywater system simultaneously alleviate water scarcity address technical environmental cost constraints includes review physicochemical microbiological characteristics rainwater greywater determine necessary treatment options review individual components potential treatment trains hybrid systems evaluation configurations hybrid systems literature review reveals untreated rainwater greywater highly variable quality quantity equalisation basin proposed normalise influent hybrid system rainwater greywater reused without treatment due presence pathogens aeromonas salmonella pseudomonas staphylococcus based literature hybrid systems categorised three configurations separate treatments rainwater greywater rainwater reused washing machines prior reuse greywater combined treatment rainwater greywater three designs rainwater requires first flush diversion disinfection combined rainwater greywater mixtures treated greywater greywater requires chemical biological physical treatment meet non potable reuse standards chemical processes effective removing solids organics surfactants light greywater whereas aerobic biological processes effective organics removal mixed dark greywaters high organic strength physical processes particularly membrane filtration recommended polishing effluents chemical biological treatment membranes foul frequently costly subsequently combination ozone chlorine recommended eradicate chlorine resistant cryptosporidium oocysts hybrid rainwater greywater systems prevent microbial regrowth elsevier ltd rights reserved
paper propose use energy load profiles learn human activities energy load profile determines energy consumption appliance specific interval time propose use clustering techniques group different profiles according temporal consumption hard soft clustering techniques evaluated tested method data remodece residential monitoring decrease energy use carbon emissions europe database
human studies demonstrate sleep impairment concurrent comorbidity autism spectrum disorders asd etiology remains largely uncertain one prominent theories asd suggests imbalance synaptic excitation inhibition may contribute various aspects asd including sleep impairments following identification nlgn mutation patients asd effects synaptic transmission social behaviours examined extensively mouse model however contributory role mutation sleep impairments asd remains unknown study showed nlgnrc knock mice established genetic model asd exhibited normal duration distribution sleep wake states significantly altered electroencephalography eeg power spectral profiles wake sleep
objective using national survey children health data set compared spouse partner relationships parent child relationships family relationships parenting stress children general health emotional difficulties coping behavior learning behavior child outcomes households sex female versus different sex continuously coupled parents biological offspring assessed whether associations among family relationships parenting stress child outcomes different household types methods parental child characteristics matched female sex parent different sex parent households children years old one parent per household interviewed telephone multivariate analyses variance multiple linear regressions conducted results differences observed household types family relationships child outcomes sex parent households scored higher parenting stress confidence interval different sex parent households confidence interval significant interactions household type family relationships household type parenting stress found child outcomes conclusion children female sex parents different sex parents demonstrated differences outcomes despite female sex parents reporting parenting stress future studies may reveal sources parenting stress
objectives study aims assess attitudes knowledge preparedness willingness dentists dental students treat people living hiv aids plwha china determine factors associated willingness treat methods surveyed dentists dental students hospitals dental schools five regions china varying plwha prevalence survey questions covered demographics well four categories regarding treating plwha knowledge scaled attitude scaled preparedness scaled willingness treat scaled composite scores category calculated weighted means confounder adjusted regression analysis performed determine factor correlated willingness treat results collected percent percent useable surveys dentists dental students respectively dentists mean composite scores poor knowledge negative attitude adequate preparedness neutral willingness students mean composite scores poor knowledge negative attitude adequate preparedness positive willingness forty five percent dentists percent dental students scores indicating positive willingness treat attitude factor consistently correlated willingness treat dentists dental students scored low categories except preparedness conclusion imperative knowledge hiv aids attitudes toward plwha improved dental training increase access effectiveness dental care plwha china enhance quality life
canadian digestive health foundation initiated scientific program assess incidence prevalence mortality economic impact digestive disorders across canada current article presents updated findings study concerning irritable bowel syndrome
due capacity self renew proliferate generate multi lineage cells adult derived stem cells offer great potential use regenerative therapies stop reverse degenerative diseases diabetes heart failure alzheimer disease others however subsets cells isolated different niches differing potential therapeutic applications stromal vascular fraction svf stem cell enriched adipose derived cell population garnered interest therapeutic regenerative medicine due ability secrete paracrine factors accelerate endogenous repair ease accessibility lack identified major adverse effects thus one easily understand rush employ adipose derived svf treat human disease perhaps faster cell preparation svf making way clinics worldwide critical preclinical research needed establish svf safety efficacy optimal standardized clinical procedures underway provide overview current knowledge driving phenomenon regulatory issues existing studies propose potential unmapped applications
detecting vehicles aerial imagery plays important role wide range applications current vehicle detection methods mostly based sliding window search handcrafted shallow learning based features limited description capability heavy computational costs recently due powerful feature representations region convolutional neural networks cnn based detection methods achieved state art performance computer vision especially faster cnn however directly using vehicle detection aerial images many limitations region proposal network rpn faster cnn poor performance accurately locating small sized vehicles due relatively coarse feature maps classifier rpn distinguish vehicles complex backgrounds well study improved detection method based faster cnn proposed order accomplish two challenges mentioned firstly improve recall employ hyper region proposal network hrpn extract vehicle like targets combination hierarchical feature maps replace classifier rpn cascade boosted classifiers verify candidate regions aiming reducing false detection negative example mining evaluate method munich vehicle dataset collected vehicle dataset improvements accuracy robustness compared existing methods
objective pooled analysis two randomized controlled trials rcts suggested increased bodyweight body mass index bmi may associated greater probability pregnancy address issue investigated whether higher bodyweight bmi negatively impacted risk pregnancy women receiving lng levonorgestrel emergency contraception unprotected sexual intercourse pooled analysis three large multinational rcts conducted world health organization methods pooled analysis three double blind multinational rcts conducted investigate efficacy lng general population analyses done per protocol set pps included women received lng within hours following unprotected sexual intercourse analysis based logistic regression pregnancy outcome bmi weight represented model results total pregnancies available analysis pps increasing bodyweight bmi correlated increased risk pregnancy studied population limitation study despite large study population pooled analysis relatively small numbers women high bmi high bodyweight subgroups conclusion lng effective preventing pregnancy unprotected intercourse contraceptive failure evidence found support hypothesis loss efficacy subjects high bmi bodyweight therefore access lng limited women lower bodyweight bmi
growing demand electric vehicles entails increased consumption critical energetic non energetic abiotic resources necessary optimal performance vehicle depletion resources future availability meet demand appears potential limitation expansion electrified vehicle industry goal study perform detailed life cycle analysis including manufacturing use disposal key components powertrains identifying materials processes responsible abiotic depletion impact study also investigates sensitivity results choice life cycle assessment lca impact methods lca performed integrated electric drive considering seven impact methods results show energetic resources consumption generate largest impact followed metals lastly mineral resources consumption electricity life cycle crucial factor generation total impact agreements among methods materials processes contributing depletion given differences approach used impact method elsevier rights reserved
transformers illustrate majority capital investment transmission distribution centers additionally interruptions power transformer significant economic effects performance electrical network reason safe reliable performance transformer directly related security stability power system paper studies growth leakage flux stray losses tank wall core clamp distribution transformer unbalanced voltage condition computer based simulation utilizing three dimensional fem improved ansoft maxwell surface impedances method tool visualizing leakage flux stray losses tank wall core clamp distribution transformers fem one among popular numerical methods able handle problem complexity various forms
recently ferrero gazzola disc cont dyn syst suggested investigated rectangular plate model describing statics dynamics suspension bridge plate assumed hinged vertical edges free remaining horizontal edges reliable model aims describe accurately motion suspension bridges compared previous known models present paper consider plate equation presence memory subject mentioned boundary conditions give rigorous well posedness result establish existence global attractor wiley vch verlag gmbh kgaa weinheim
bacterial cellulose strong ultrapure form cellulose produced naturally several species acetobacteraceae high strength purity biocompatibility make great interest materials science however precise control biosynthesis remained challenge biotechnology isolate strain komagataeibacter rhaeticus rhaeticus igem produce cellulose high yields grow low nitrogen conditions highly resistant toxic chemicals achieved external control bacterial cellulose production development modular genetic toolkit enables rational reprogramming cell use organism biotechnology sequenced genome demonstrate genetic circuits enable functionalization patterning heterologous gene expression within cellulose matrix work lays foundations using genetic engineering produce cellulose based materials numerous applications basic science materials engineering biotechnology
popularity bus rapid transit brt makes trans jogja alternative mass public transportation system urban mobility however without supervision temporal patterns passenger behavior trans jogja supply demand result decreases number brt users increasing number private vehicle users traffic jams remain difficult avoid smart card automated fare collection system scafcs currently used ticketing trans jogja public transport used analyze passengers pattern data mining approaches paper applied scafcs data preprocessing data warehouse mechanism implemented hadoop platform distributed computing improve means clustering performance large datasets scalability case scafcs trans jogja large dataset volume rapid growth data velocity scalable means algorithm generates five clusters characteristics number clusters namely low low average high high clusters used analyze passengers pattern based dimensions time temporal segmentation passengers structure determine variability passengers based card used transaction peak boarding location spatio experimental testing setup performed comparing sum square error sse total squared error cluster centroid three algorithms simple means means means implementation using hadoop platform parallel distributed computing means hadoop platform implementation generates smaller sse value simple means means algorithms shows good sse value
pedestrian suspension bridge walker creek near route giles county virginia partially collapsed october causing people fall creek failure occurred one anchors holding suspension cable fractured paper presents investigation failure including structural analysis bridge determine cable forces material property testing fractured anchor laboratory testing different anchor bridge simple strength evaluation anchor combined axial force moment based results study concluded anchor failed carrying loads bridge day failure anchor failed brittle fracture local defect material perimeter corrosion pit surface anchor hook structural analysis laboratory testing indicated material around defect yield fracture initiation material flaws significantly influenced bridge failure yielding inelastic deformation anchor material inside hook radius occurred american society civil engineers
introduction cell encapsulation technology still challenging issue innovative methodologies additive manufacturing alternative bioprocesses cell therapeutic delivery cell encapsulation key tool rapidly gaining importance potential regenerative medicine responsive materials elastin based recombinant expression products features particularly attractive cell encapsulation designed tailored meet desired requirements thus represent promising candidates development new concept based materials employed field areas covered overview design employment elastin like polypeptides cell encapsulation given outline state art special attention paid design macromolecule employed well method matrix formation biological system involved expert opinion result recent progress regenerative medicine compelling need materials provide specific properties demonstrate defined functional features rationally designed materials may adapt according applied external stimuli responsive biological systems elastin like polypeptides belong class smart material run components described date represents good starting point advancement area employment components cell encapsulation application promote advance toward smart cell encapsulation technology
incorporating sustainability construction result desirable building attributes project life cycle leadership engineering environmental design leed rating system helps project teams make right green building decisions projects process however current practice project teams systematic procedure tool choosing leed credits appropriate particular project researchers developed tool support leed integrative process charrette developed optimization model utilized assist project teams determine credits pursue leed certification taking account potential benefits associated leed credit tool enables owners incorporate sustainability construction helping project teams make right green building decisions projects integrated procedure
carbon dioxide storage technology carbon capture storage ccs components exposed corrosive environment mechanical stress results corrosion fatigue inevitably followed lifetime reduction components order gain knowledge upon corrosion fatigue strength materials samples high alloyed stainless injection pipe steels aisi xcr xcrnicunb aisi tested degrees ambient pressure saturated synthetic aquifer environment similar possible geological shore ccs sites northern german basin therefore corrosion chamber applied resonant testing machine allowing situ test conditions designed successfully tested situ tension compression experiments established using resonant testing machine frequency low addition technical introduced closed system rate close keep stable environmental conditions simultaneously electrochemical testing performed get information failure causes mechanism failure injection deep geological layers plots micrographic analysis surface analysis fracture surface applied obtain sustainable information corrosion fatigue behavior injection pipe steels samples used surface roughness simulate technically machined surfaces xcr reached maximum number cycles stress amplitude mpa xcrnicunb reached maximum number cycles stress amplitude mpa scatter range xcrnicunb high comparison scatter range xcr authors published elsevier ltd
atopic eczema synonymous atopic dermatitis common heterogeneous phenotype wide spectrum severity mild transient disease severe chronic disorder atopic non atopic comorbidities eczema complex trait resulting interaction multiple genetic environmental factors skin organ biopsied easily provides opportunities detailed molecular genetic analysis strategies applied investigation atopic eczema include candidate gene genome wide studies extreme phenotypes comparative analysis inflammatory skin diseases genetic studies identified central role skin barrier impairment eczema predisposition perpetuation brought paradigm shift understanding atopic disease specific molecular targets improve skin barrier function remain elusive role mediated immune dysfunction also central atopic inflammation proved powerful target biological therapy atopic eczema advances understanding eczema pathogenesis provided opportunities patient stratification primary prevention therapy development remain considerable challenges application knowledge optimize benefit patients atopic eczema era personalized medicine copyright pathological society great britain ireland published john wiley sons ltd
individuals autism spectrum disorders asd show significant impairments social skills theory mind tom aim study evaluate tom social information processing abilities children asd compared typically developing children mediation analysis evaluated whether social information processing abilities mediated tom competences results children autism showed deficit social skills tom components innovative results study applying mediation analysis demonstrate tom plays key role development social abilities lack tom competences children autism impairs competent social behavior
recent days due rapid technological advancements grid computing become important area research grid computing emerged new field distinguished conventional distributed computing focuses large scale resource sharing innovative applications cases high performance orientation grid network computational resources may potentially span many continents grid serves comprehensive complete system organizations maximum utilization resources achieved load balancing process involves resource management effective load distribution among resources therefore considered important grid systems proposed work presents extensive survey existing load balancing techniques proposed far techniques applicable various systems depending upon needs computational grid type environment resources virtual organizations job profile supposed work models merits demerits forms subject matter survey detailed classification various load balancing techniques based different parameters also included survey elsevier ltd rights reserved
methods materials liquid encapsulation thin silicone membranes presented work set liquids including solvents oils silicone pre polymers one ionic liquid experimentally tested show selected liquids chemically inert silicone vapor pressure key parameter stable encapsulation demonstrated encapsulated volume silicone pre polymers ionic liquids stay stable month actuation dielectric elastomer actuators deas conductive liquids also investigated analysis equivalent electrical circuits immersed deas shows non overlapping regions electrodes minimized also provides guidelines determine electrodes passivated effects immersion conductive liquid assessed measuring actuation strain capacitance periodic actuation experimental results show sign liquid induced degradation actuation cycles
paper presents novel approach non standard timber assembly robotic timber construction rtc robotic fabrication used expand additive digital fabrication techniques towards industrial full scale dimensions featuring robotic systems grasp manipulate finally position building components according precise digital blueprint rtc combines robotic assembly procedures advanced digital design nonstandard timber structures resulting architectural morphologies allow convergence aesthetic functional concerns enabling structural optimisation locally differentiated aggregation material initiated group gramazio kohler research eth zurich approach offers new perspective automated timber construction focus shifted processing single parts towards assembly generic members space rtc promotes unique advantages conventional approaches timber construction example cnc joinery cutting automated placement material exactly needed rtc combines additive largely waste free construction economic assembly procedures require additional external building reference offers digital control across entire building process even design assembly information highly complex paper considers research parameters individual components rtc computational design processes construction methods fabrication strategies architectural implications integrating components systemic unifying process earliest stages design overall rtc leads profound changes design performance expressive language architecture thus fosters creation architecture profoundly reinvents constructive repertoire elsevier rights reserved
transitioning university involves major life change implications physical mental health study three objectives first assess mental health health behavior participation australian university students second evaluate clustering health behaviors third examine mental health relates health behaviors university students enrolled australian regional university completed online survey containing depression anxiety stress scales health behavior questionnaire one third students reported mild higher mental illness symptoms reported engaging multiple unhealthy behaviors furthermore mental health associated unhealthy behaviors males depressive symptoms associated skipping breakfast poor sleep quality females depressive symptoms associated skipping breakfast inadequate vigorous physical activity short long sleep hours stress symptoms females associated healthy sleep hours poor sleep quality future research may consider whether intervention targeting one two key health behaviors utility improving participation health behaviors mental health
developing web based programming education support tool pgtracer plug well known learning management system moodle pgtracer provides fill blank questions composed program trace table students student answers question filling blanks pgtracer collects student answers required time evaluation result etc student log pgtracer also provides various analysis functions collected log teacher utilize analysis functions order analyze student achievement level difficulty level problems paper propose methods analyze achievement level students utilizing analysis functions perform evaluation experiment students order validate methods result difference discovered answer process caused achievement level student proposed method useful analyze achievement level students detail
evolution information technology emergence ambient intelligence paradigm drastically affected way users live learn ambient intelligence vision future offers great opportunities enrich everyday activities road home work etc proven play important role education smart learning environments learning activities enhanced use pervasive mobile computing paper presents extensible software infrastructure empowers teachers design program purposeful engaging learning activities formal informal learning environments combining orchestrating cloud based ambient pervasive facilities services
background helicobacter pylori colonizes gastric mucosa half world population increasing evidence pylori protects development obesity childhood asthma allergies development diseases coincide transient dysbiosis however mechanism underlying association pylori eradication human metabolic immunological disorders well established study aimed investigate local systemic effects pylon eradication untargeted fecal lipidomics plasma metabolomics approaches liquid chromatography mass spectrometry results study revealed eradication pylori eradication loss pylori pylori eradication therapy changed many global metabolite lipid features majority regulated findings primarily show pylori eradication affects host energy lipid metabolism may eventually lead development metabolic disorders conclusion predictive metabolic signatures metabolic immunological disorders following pylori eradication provide insights dynamic local systemic metabolism related pylori eradication modulating human health
background purpose study carried investigate whether toll like receptor tlr variant common taiwanese population contributes pathogenesis allergy methods tlr ligand pamcsk stimulated cytokine production peripheral blood mononuclear cells monocyte derived dendritic cells different genotypes measured via enzyme linked immunosorbent assay ninety three taiwanese allergic patients asthma allergic rhinitis atopic dermatitis controls recruited genotyping serum immunoglobulin ige levels evaluated allergic patients results homozygous tlr variant allele carrier increased pamcsk induced tumor necrosis factor alpha interleukin responses peripheral blood mononuclear cells monocyte derived dendritic cells respectively furthermore although genotype associated susceptibility atopic diseases correlated lower total ige levels sera allergic patients conclusion data suggest tlr polymorphism might play role differentiation determination serum ige levels however interactions genetic environmental factors might required contribute risk allergic diseases population copyright taiwan society microbiology published elsevier taiwan llc
project managing water scarcity intelligent tools cooperative strategies funded european commission aimed pointing potential increasing water use efficiency yongding river basin sub basin hai river basin north east china implemented last years collaboration following partners china foreign economic cooperation office ministry environment development research centre ministry water resources tsinghua university tianjin environmental protection technology development centre paper presents main results project project studied structural non structural measures increasing water use efficiency sectors agriculture industry domestic use agricultural water use project studied potential limitations micro irrigation technologies yongding river basin based case study evaluations industrial water use project studied potential increasing water use efficiency relevant industries yongding river basin textile chemical power industry industry factories selected strategies improve water use efficiency elaborated domestic water use domestic water use comprised showers toilets washing machines uses beijing largest water users showers followed toilets washing machines water saving types available potential constraints mainstreaming water saving types investigated based user surveys rainwater harvesting rwh rwh considered large potential yongding river basin applied limited extent studies shown water use efficiency considerably increased yongding river basin implementing water saving technologies studied sectors facilitate implementation non structural measures policy instruments substantially help experiences policy instruments surveyed improved policy instruments suggested policy instruments discussed various stakeholders yongding river basin based feedback policy recommendations elaborated
authors propose diagnostic technique state space model fitting time series deleting observations measuring change parameter estimates consider approach order distinguish observational outlier innovational one thus present robust subspace identification algorithm less sensitive outliers monte carlo simulation vibrating structure model demonstrates effectiveness proposed algorithm ability detect outliers measurements well dynamical state
quantum private comparison qpc aims accomplish equality comparison secret inputs two users basis leaking contents recently chen proposed qpc protocol based triplet ghz state single particle measurement optics communications paper suggested standard model semi honest third party first time declared protocol secure subsequently lin pointed chen protocol one user extract user secret without discovered performing intercept resend attack suggested two corresponding improvements optics communications however yang first pointed model adopted chen protocol lin improved protocols unreasonable thought practical may also try possible means steal users secrets except corrupted adversary including dishonest user quantum inf process paper taking possible attacks account propose eavesdropping strategy toward lin improved protocols suggest two feasible solutions accordingly
present visual assistive system features mobile face detection recognition unconstrained environment mobile source using convolutional neural networks goal system effectively detect individuals approach facing towards person equipped system find face detection recognition becomes difficult task due movement user causes camera shakes resulting motion blur noise input visual assistive system due shortage related datasets create dataset videos captured mobile source features motion blur noise camera shakes makes application challenging aspect face detection recognition unconstrained environments performance convolutional neural network compared cascade classifier results show promising performance daylight artificial lighting conditions challenges lie moonlight conditions need reduction false positives order develop robust system also provide framework implementation system smartphones wearable devices video input auditory notification system guide visually impaired elsevier rights reserved
research studies emptying box problem porous baffle behind entrance opening theoretical model extended include effect porous baffle theoretical model taking account porosity establishes connections two typical unidirectional displacement flow types salt bath technique employed conduct experiments using acrylic reduced scale model dye attenuation technique used analyze light intensity data derived recorded images experiments according baffle porosity percentage phi experiments categorized two series series respectively includes three different opening area ratios experimental results show emptying processes cases baffle larger porosity percentage consist emptying dense layer emptying mixed layer one process emptying dense layer cases baffle smaller porosity percentage experimental results reasonable agreement extended theoretical model developed research two extreme cases without impenetrable baffle included paper represent two typical flow types horizontal inflow denoted phi vertical inflow denoted phi unidirectional classical displacement flow displacement flow interfacial mixing porosity percentage increases emptying time dense layer decreases emptying time whole box tends increase emptying time dense layer decreases total effective opening area reduced gravity increases cases porosity percentage initial interfacial height mixed layer increases baffle porosity percentage increases cases fixed total effective opening area total effective opening area increases cases baffle porosity percentage initial buoyancy mixed layer dependent penetrative entrainment flow rate dense layer mixed layer emptying time dense layer total effective opening area porosity percentage increases experimental results show initial buoyancy mixed layer tends increase penetrative entrainment flow rate increases well emptying time dense layer decreases elsevier ltd rights reserved
introduction overactive bladder syndrome oab dysfunctional voiding subgroups lower urinary tract dysfunction lutd standard urotherapy first line treatment option oab children objectives aim investigate use biofeedback first line treatment option oab refractory standard urotherapy determine factors affecting efficacy study design retrospectively analyzed total hospital records children oab previously used anticholinergics refractory standard urotherapy patients urgency urge incontinence making holding maneuvers suppress urgency defined oab symptoms resolution complaints defined successful biofeedback therapy results seventy three oab patients urgency recovered biofeedback therapy success rate sixty two patients holding maneuvers success rate patients urgency incontinence success rate patients daytime incontinence success rate patients enuresis success rate patients dysuria success rate recovered symptoms significantly mean lower urinary tract symptom score lutss biofeedback therapies respectively table patients without holding maneuvers daytime incontinence enuresis better recovery compared opposites discussion biofeedback thought first line treatment option standard urotherapy fails children oab
study design case report review relevant literature objective report rare complication esophageal perforation cervical fracture patient progressive ankylosing spondylitis review relevant literature summary background data esophageal perforation cervical fracture extremely rare complication never reported patients key points early diagnosis management severe complication along cervical fracture presented detail case report methods year old male sustained fracture dislocation vehicle accident initial treatment strategy combined anterior posterior fixation fusion although esophageal perforation dorsal wall esophagus detected anterior surgery thorough debridement esophageal lesion closed resorbable interrupted sutures surgical incision washed saline hydrogen peroxide without primary closure cervical fracture treated long level posterior fixation alone surgery anterior surgical incision irrigated normal saline twice day closed weeks later results esophageal perforation healed completely neurologic results improved significantly surgery union fracture segmental stability cervical spine confirmed radiologically year follow conclusion esophageal perforation cervical fracture patient progressed extremely rare potentially life threatening complication surgical debridement drainage intensive care essential good outcome
indications liver transplant extended older sicker patients undergoing transplantation infectious malignant cardiovascular diseases account posttransplant deaths cirrhotic patients develop heart disease systemic diseases affecting heart liver cirrhosis specific heart disease common cardiovascular single factor predict posttransplant cardiovascular complications patients history cardiovascular disease specific abnormalities echocardiography electrocardiography serum markers heart disease seem increased risk complications pre transplant cardiovascular evaluation essential detecting risk factors effects mitigated appropriate intervention
paper presents wearable inertial pedestrian navigation system associated pedestrian trajectory reconstruction algorithm reconstructing pedestrian walking trajectories indoor outdoor environments proposed wearable inertial pedestrian navigation system constructed integrating triaxial accelerometer triaxial gyroscope triaxial magnetometer microcontroller bluetooth wireless transmission module users wear system foot walking indoor outdoor environments normal speed without external positioning techniques walking movement measured inertial signals generated walking movements transmitted computer via wireless module based foot mounted inertial pedestrian navigation system pedestrian trajectory reconstruction algorithm composed procedures inertial signal acquisition signal preprocessing trajectory reconstruction trajectory height estimation developed reconstruct floor walking stair climbing trajectories order minimize cumulative error inertial signals utilized sensor fusion technique based double stage quaternion based extended kalman filter fuse acceleration angular velocity magnetic signals experimental results successfully validated effectiveness proposed wearable inertial pedestrian navigation system associated pedestrian trajectory reconstruction algorithm
background participatory approaches involving stakeholders across health care system help enhance development implementation evaluation health services approaches may particularly useful planning community pharmacy services overcome challenges implementation practice conducting stakeholder analysis key first step since allows relevant stakeholders identified well providing planners better understanding complexity health care system objectives main aim study conduct stakeholder analysis identify individuals organizations could part leading planning group development community pharmacy service cps prevent cardiovascular disease cvd australia methods experienced facilitator conducted workshop key informants australian health care system two structured activities undertaken first explored current needs gaps cardiovascular care role community pharmacists second stakeholder analysis using ante hoc approaches identified stakeholders classified three groups according relative influence development pharmacy service information gathered analyzed using qualitative content analysis results key informants identified stakeholders including patient consumers representative organizations health care providers professional organizations institutions organizations directly interact patients organize manage health care system develop implement health policies pay health care influence funding health service research promote new health initiatives stakeholders core group stakeholders defined considered crucial service development held positions could drive inhibit progress secondary results workshop included list needs gaps cardiovascular care list roles community pharmacists cardiovascular prevention list potential factors hinder integration community pharmacy services practice conclusions stakeholder analysis provided detailed picture wide range stakeholders across entire health care system stake development community pharmacy service aimed preventing cvd core group key stakeholders complementary roles approached planning service results analysis highlight relevance establishing multilevel stakeholder groups cps planning elsevier inc rights reserved
target villages rainwater harvesting trap impermeable pavement prevent rainwater runoff rainwater accumulated mainly used domestic miscellaneous water environmental ecological water low impact development lid analog natural stormwater management rainwater collection system based concept lid stormwater control easy operate inexpensive according characteristics village rainwater harvesting towns rainwater collection system divided five parts roof rainwater harvesting courtyard rainwater harvesting street rainwater harvesting green rainwater harvesting landscape rainwater storage pond summarize principles rainwater collection systems towns villages landscape applications low impact low maintenance low cost design nature design life overall planning collaborative implementation provide reference ecological circular village rainwater resource utilization
purpose present development evaluation robust hand tracker based single overhead depth images use coach assistive technology people dementia new hand tracker designed overcome limitations experienced coach previous clinical trials methods train random decision forest classifier using similar manually labeled unbalanced training images hand positions classifier translated task actions based proximity environmental objects tracker performance evaluated using large set similar manually labeled images captured participants fully functional washroom compared system previous colour based hand tracker results precision recall depth tracker compared colour tracker current data previous study conclusions improved tracking performance supports integration depth based tracker coach toward unsupervised real world trials implications rehabilitation coach intelligent assistive technology enable people cognitive disabilities stay home longer supporting concept aging place automated prompting systems type intelligent assistive technology help support independent completion activities daily living increasing independence people cognitive disabilities reducing burden care experienced caregivers robust motion tracking using depth imaging supports development intelligent assistive technologies like coach robust motion tracking also application forms assistive technologies including gaming human computer interaction automated assessments
aimsrecent studies used different neuroimaging techniques identified various brain regions activated bladder filling however lack consensus regarding brain regions regulate process urine storage aim meta analysis identify brain regions commonly activated bladder filling healthy adults across different studies methodspubmed searched neuroimaging studies investigating effects bladder filling regional brain activation studies excluded report brain activation differences whole brain group analysis comparing state bladder filling state bladder rest current version activation likelihood estimation ale approach used meta analysis resultswe identified neuroimaging studies examining brain activation response experimental bladder filling healthy subjects reported foci ale analysis meta analysis revealed significant activation multiple brain regions including thalamus bilaterally right insula cerebellum brainstem bilaterally conclusionsseveral key brain regions involved sensory processing commonly activated bladder filling healthy adults across different studies neurourol urodynam wiley periodicals inc
intentional childhood poisoning uncommon formof child abuse high risk morbidity mortality patients present four main categories illness metabolic derangements salt water ingestion gastrointestinal symptoms laxative ipecac poisoning hemorrhagic disease warfarin superwarfarin exposures neurologic symptoms central nervous systemdepression excitation widely available routine urine drug screens limited value clinicians must high index suspicion make diagnoses
mental health related stigma affects people mental disorders families aimed investigate experience stigma among relatives patients schizophrenia belarus formulate recommendations anti stigma interventions conducted thematically analysed interviews relatives people diagnosed schizophrenia experience discrimination strategies cope requests interventions examined number themes related experience stigma public life relatives people schizophrenia elicited relation mental health care difficulties contacting mental health professionals getting appropriate information lack alternatives hospital treatment absence appropriate long term care services employment people living schizophrenia contact police analysis strategies used overcome difficulties revealed resignation passive acceptance self reliance emotional containment crises despite passivity scepticism expressing needs participants suggested number interventions could reduce burden stigma respect public domain life substantial stigma discrimination perceived families people living schizophrenia belarus associated structural issues country mental health care system reduce stigma related burden action must taken educate support families deal structural issues reorganising mental health services better meet needs families people diagnosed schizophrenia including decision making levels
background specialized parkinson disease care offers advantages patients however specialized health care providers may unaware patients personal context comorbidity leading conflicting treatment regimens patients may benefit holistic approach objective clarify role community dwelling patients see general practitioners gps care clarify role gps see methods qualitative interview study community dwelling patients gps netherlands using constant comparative approach analysis results patients expressed preference self management autonomy decisionmaking gps chose limited reactive position early stage care stimulate patient autonomy moreover gps felt insufficiently competent extend role patients also felt gps lack expert knowledge skills focus neurologist care addition gps observed patients might realize accessory role could role gps described essential aware patient well patients describe additional roles advanced disease whereas gps mentioned shift towards proactive extended role conclusion patients gps see limited role early stage care patient autonomy lack specific knowledge skills however gps feel confident added value generalist approach care patients complex chronic disorder generalist specialized care reinforce patients benefit
single isa asymmetric multicore processors amps combine high performance big cores low power small cores shown deliver higher performance per watt symmetric cmps chip multi processors previous work highlighted potential amp systems realizable via scheduling date existing scheduling schemes amps designed optimize system throughput inherently unfair although fairness aware schedulers also proposed fail effectively deal user priorities always ensure equal priority applications experience similar slowdown overcome limitations propose acfs asymmetry aware completely fair scheduler seeks optimize fairness ensuring acceptable throughput evaluation real amp hardware using scheduler implementations linux kernel demonstrates acfs achieves average fairness improvement two state art schemes providing higher system throughput elsevier inc rights reserved
large number methods applied evaluate genotoxic damage different aquatic species comet assay method detecting dna alterations micronucleus test index chromosomal damage widely used authentic methods laboratory field studies primary objective study evaluate genotoxic effects heavy metals generated toxic industrial effluents various kinds pollutants urban agricultural areas domestic waste catla catla cirrhinus mrigala due water pollution chenab river pakistan heavy metals detected atomic absorption spectrophotometry water samples collected predetermined sampling sites physicochemical parameters heavy metals found exceed upper limits recommended various agencies comet assays showed significant dna damage mrigala compared catla tail length olive tail moment three different sites significant findings observed fish collected farmed non polluted upstream waters micronucleus assays showed similar findings single double micronucleus induction catla mrigala significantly higher micronuclei induction percent tail dna observed mrigala specimen collected polluted site findings infer dna damage could used biomarker pollution load early monitoring using simple reliable techniques comet micronucleus assays expedient methods toxicity screening aquatic environments regular monitoring necessary assess eco health chenab river choosing perhaps mrigala bottom feeder bioindicator could provide reliable information determine status environmental quality river
important pre filtering procedure object detection objectness estimation draws lots attentions video analysis computer vision communities among existing approaches bing binarized normed gradients recently proposed one possesses advantages high object detection rate ultra fast computational speed fps small number proposals good generalization ability however within bing framework uniform hierarchical ranking structure gradient information employed objectness characterization leads high false positive rate address issue effective efficient cascade ranking method proposed refine bing paper declares three main contributions first concept scale sets histogram novelly introduced helps analyze potential sizes objects secondly descriptive visual features color texture consistence considered simultaneously objectness characterization lastly propose hierarchical sorting leverage ranking performance according local contrast analysis inside straddling superpixels object proposal windows experimental results four challenging datasets pascal voc pascal voc pascal voc ilsvrc demonstrate refined bing achieve good balance high detection rate proposal windows voc low time consumption per image voc also worth noting relatively small number proposals fewer proposals approach generally outperforms state art methods detection rate testing datasets elsevier rights reserved
although dozens studies documented relationship violent video games aggressive behaviors little attention paid potential effects prosocial games theoretically games game characters help support nonviolent ways increase short term long term prosocial behaviors report three studies conducted three countries three age groups test hypothesis correlational study singaporean middle school students played prosocial games behaved prosocially two longitudinal samples japanese children adolescents prosocial game play predicted later increases prosocial behavior experimental study undergraduates randomly assigned play prosocial games behaved prosocially toward another student similar results across different methodologies ages cultures provide robust evidence prosocial game content effect provide support general learning model
food supply consumption critical sustaining urban system functions key determinants quantity pathways nutrient flow cities nutrient elements urban food consumption becoming major pollutant sources urban environments therefore understanding flow magnitude pathways role growing population changing dietary structure technology future nutrient metabolism essential understand cities ecosystems urban environmental management taking city xiamen rapid urbanizing area southeast china case study simulated urban metabolism three major food sourced nutrient elements carbon nitrogen phosphorus cnp environmental emissions impacts future population growth dietary habit change waste treatment improvement various environments forecast scenario analysis sensitivity analysis conducted test different waste treatment technologies affect environmental emissions food sourced nutrients results show food sourced cnp various metabolic fluxes urban systems carbon mostly emitted air nitrogen phosphorus mostly discharged landfills water population growth dietary structure change accelerate increases nutrient emissions environment whereas enhancing current waste treatment technology alter emissions different environments based results discuss food sourced nutrient metabolism better managed enhance connectivity cities hinterlands maintain environmental emissions within carrying capacity cities published elsevier ltd
cochlear implant also called bionic ear electronic cochlea implantable electronic device partially restore hearing profoundly deaf patients directly stimulating patient auditory nerve via surgically implanted electrode arrays hearing impairment severely deaf patients translates hearing loss reaching hearing dynamic range low gain control systems needed cis map acoustic input signal patient hearing dynamic range paper proposes programmable gain amplifier pga used implement dual loop automated gain control agc analog signal processing technique used due advantages digital processing equivalents potentially lower power consumption higher processing speed programming analog processing parameters gain levels time constants done means digital control words set values corresponding bias currents computation control words done digital fashion allowing hardware description language implementation gain control algorithm adds flexibility resulting gain control system ability choose feed forward feed back topology ability choose different compression functions linear logarithmic power law ability set desired compression limits finally fully adaptive gain control system implemented programmable aspect adaptive agc implementation also enables adjustment agc operation meet patient individual needs circuit simulation proves functionality proposed pga automated gain control applications
investigate packet scheduling function within access scheme unidirectional satellite system providing point multipoint services mobile users satellite system may regarded overlay multicast broadcast layer complementing point point third generation mobile terrestrial networks satellite access scheme features maximum commonalties frequency division duplex fdd air interface terrestrial universal mobile telecommunications system umts also known wideband code division multiple access wcdma thus enabling close integration terrestrial mobile networks cost efficient handset implementations draw attention one radio resource management entities relevant interface packet scheduler lack channel state information point multipoint service offering differentiate packet scheduler satellite radio interface counterpart point point terrestrial mobile networks formulate scheduler tasks describe adaptations two well known scheduling disciplines multilevel priority queuing weighted fair queuing schemes candidates time scheduling function simulation results confirm significance transport format combination set tfcs respect resource utilization achieved scheduler performance obtained flows packet level performance gap two schemes regarding fairness provided competing flows narrowed via appropriate selection tfcs whereas achieved delay delay variation scores ultimately dependent packet level dynamics individual flows copyright john wiley sons ltd
recent research suggests among group aggressive antisocial adolescents distinct variants exhibit different levels anxiety symptoms callous unemotional traits traits purpose present study examine whether variants also present male female adolescents diagnosed conduct disorder used model based cluster analysis disaggregate data adolescents boys girls mean age years living child welfare juvenile justice institutions three variants identified moderate traits anxiety symptoms severe traits variants differed external validation measures assessing anger irritability externalizing behavior traumatic experiences substance use variant moderate traits anxiety symptoms severe pattern psychopathology results also indicated distinct profiles personality development three variants gender specific comparisons revealed differences girls boys clustering external validation measures gender specific cluster affiliation present results extend previously published findings variants among aggressive antisocial adolescents male female adolescents diagnosed
background heterogeneity autism spectrum disorder asd remains poorly understood particularly individuals without intellectual disability phenotypic variability pronounced presence phenotypic subgroups continues questioned study investigated whether children asd without differentiable clinically meaningful subgroups method data gold standard asd diagnostic instruments children years asd without subjected exploratory cluster analysis cognition language pragmatic communication behaviour used explore subgroups results children asd without could differentiated moderate severe social impairment subgroups core asd symptoms closely examined moderate social impairment subgroup showed less severe social interaction communication impairments greater lifetime severity restricted repetitive behaviours contrast severe social impairment subgroup poorer social interaction communication skills lower lifetime severity restricted repetitive behaviours subgroup also greater cognitive language difficulties poorer adaptive functioning importantly however neurocognitive functional differences showed small moderate associations differentiated asd clinical profiles conclusions evidence dissociated levels severity across core asd dimensions supports idea clinically meaningful subgroups within asd without identified dissociated profiles asd features could represent different underlying neurobiologicalmechanisms subgroup identifying subgroups practice improve clinical utility diagnostic labels population thus categorical dimensional approaches may useful classifying asd neither alone adequate elsevier ltd rights reserved
long debated whether attitudinal ambivalence elicits negative affect evidence link inconclusive using facial emg tested idea affective responses ambivalence dependent inconsistency evaluations current situation person perception task participants presented positive friendly intelligent negative jealous dominant positive negative information intelligent dominant different target persons participants exposed information without respond ambivalent information elicited affective response positive stimuli participants showed zygomaticus positive affect less corrugator activation negative affect negative stimuli task participants make choice ambivalent information elicited affective response negative information task qualified possibility resolve inconsistency evaluations specifically ambivalence led relative decrease positive affect evaluative context help resolve inconsistency ambivalent evaluations created choice conflict bob intelligent dominant think bob good collaborator ambivalent information bob intelligent dominant presented context opposing evaluations inconsistent think bob write good research paper participants reported experience lower levels conflict displayed positive affect zygomaticus activation current data contribute reconciliation previously inconclusive results affective responses attitudinal ambivalence results suggest ambivalence leads relatively negative affect decrease positive affect ambivalent information inconsistent current situation thus creates conflict implications findings discussed elsevier inc rights reserved
article use fractional complex transformation convert nonlinear partial fractional differential equations nonlinear ordinary differential equations algebraic method improved construct uniformly series exact solutions nonlinear time space fractional partial differential equations construct successfully series exact solutions including elliptic doubly periodic solutions aid computerized symbolic computation software package maple mathematica method efficient powerful solving wide classes nonlinear partial fractional differential equations jacobi elliptic doubly periodic solutions generated trigonometric exact solutions hyperbolic exact solutions modulus respectively
backgroundshort chain fructooligosaccharides scfos beneficial effects subjects minor digestive complaints potential mechanisms involved elucidated aim study evaluate changes rectal sensitivity related clinical effects scfos selected group patients irritable bowel syndrome ibs rectal hypersensitivity methodsin ibs patients defined rome iii criteria rectal hypersensitivity defined discomfort threshold parallel placebo controlled randomized double blind study performed assess effects dietary supplementation scfos placebo weeks rectal sensitivity primary outcome tolerance increasing wall tension applied tensostat clinical outcomes ibs anxiety depression quality life scores composition fecal microbiota key resultsrectal discomfort threshold ibs quality life scores significantly improved treatment similar manner scfos placebo groups post hoc analysis showed effect scfos rectal sensitivity pronounced constipation predominant ibs patients placebo contrary placebo scfos significantly reduced anxiety scores increased fecal bifidobacteria without modifying bacterial groups conclusions interfencesthe effect scfos anxiety may related modulation gut microbiota demonstration effects scfos rectal sensitivity may require higher doses may depend ibs subgroup
water pollution cause serious concern today world major contributor water pollution industrial effluents containing dyes organic molecules waste water treatment become priority area today applied scientific research seeks minimize toxicity effluents discharged increase possibility water recycling efficient eco friendly way degrading toxic molecules use nano metal oxide photocatalysts present study aims enhancing photocatalytic activity semiconductor metal oxide doping nitrogen sol gel cum combustion method employed synthesize catalyst prepared catalyst characterized xrd drs fesem afm techniques drs result showed catalyst possess band gap energy thus making active region spectrum photo catalytic activity evaluated degradation model pollutant orange dye light irradiation preliminary experiments carried study effects catalyst dosage initial dye concentration extent dye degradation kinetic studies revealed reaction followed pseudo first order kinetics effect electrolytes catalyst efficiency also studied progress reaction monitored absorption studies measuring reduction cod catalyst thus prepared seen high photocatalytic efficiency use catalyst promising means waste water treatment elsevier inc rights reserved
understanding people form impressions others key goal social cognition research past theories posited two fundamental dimensionswarmth competenceunderlie impression formation however models conflate morality warmth fail capture full role moral character plays impression formation emerging perspective separates moral character morality warmth theoretical empirical grounds morality pitted warmth morality clearly important driver impression formation revealed correlational experimental archival studies yet social warmth remains important conveys distinct information morality alongside competence factors matter person perception also aspects social cognition including group perception important unanswered questions remain regarding perceived structure moral character way appraised everyday life
theory network reliability applied many complicated network structures computer communication networks piping systems electricity networks traffic networks theory used evaluate operational performance networks modeled probabilistic graphs although evaluating network reliability non deterministic polynomial time hard problem numerous solutions proposed however based sequential computing utilizes benefits multi core processor architectures paper addresses limitation proposing efficient strategy calculating two terminal terminal pair reliability binary state network uses parallel computing existing methods analyzed efficient method calculating terminal pair reliability based logical probabilistic calculus proposed finally parallel version proposed algorithm developed first study implement algorithm estimating terminal pair reliability parallel multi core processor architectures experimental results show proposed algorithm parallel version outperform existing sequential algorithm terms execution time copyright john wiley sons ltd
computational thinking increasingly important focus computer science informatics curricula around world ways incorporating school curricula sought bebras contest informatics originated years ago involves around countries consists short problem solving tasks based topics informatics bebras tasks engender development computational thinking skills incorporating abstraction algorithmic thinking decomposition evaluation generalization bebras tasks cover range informatics concepts including algorithms data structures programming networking databases social ethical issues built substantial number bebras tasks years important able categorize easily accessed bebras community teachers within schools categorization tasks within bebras important ensures tasks span wide range topics several categorization schemes suggested date paper present new two dimensional categorization system takes account computational thinking skills well content knowledge examples given recent tasks illustrate role bebras play development computational thinking skills
photocatalysis already triggered enormous researches areas solar energy transfer environmental purification organic synthesis etc work photocatalytic reactions applied controllably prepare nanostructured mno coo tio hybrids highly distributed active components loading flocculent mno tio nanorods rapidly achieved redox reactions mno photoexcited electrons three steps involved formation mno coo hybrids namely oxidation photogenerated holes deposition intermediate coooh mno finally decomposition coooh calcination form coo selective catalytic reduction scr chosen model reaction explore application found unique mno coo tio hybrids exhibited promoted low temperature performance compared prepared via impregnation attributed abundant mno species surface active oxygen surface species acid sites believe mno coo tio hybrids also interested applications environmental catalysis elsevier rights reserved
charcoal rot caused macrophomina phaseolina affects economically important crops around world northwestern argentina disease present seasons dry hot weather efficacy seed treatments two biological products trichoderma viride bacillus subtilis one chemical treatment thiophanate methyl pyraclostrobin evaluated field control two soybean cultivars tucuman argentina field tests added soil planting growing seasons plant emergence reduced cultivars munasqa respectively disease severity scale inoculated control scored munasqa season munasqa likewise cfu values inoculated control increased season munasqa crop yield seed weight also reduced fungal infection although treatments counteracted reduction genotypes disease severity higher munasqa coincident highest cfu values seed weight two cultivars differ significantly among treatments highest yields obtained chemically treated plots followed treated trichoderma bacillus
study presents band differential voltage controlled oscillator vco robust start hybrid technique combines open loop digitally controlled tail current switchable auxiliary cross coupled pairs accps proposed ensure robust start wideband operation compared prior closed loop current controlling method proposed technique suffer phase noise degradation furthermore evenly distributing accps transistors smaller size allowed achieve start condition leads frequency boost phase noise improvement implemented complementary metal oxide semiconductor technology vco achieves wide frequency tuning range ghz low phase noise dbc mhz offset ghz carrier frequency power supply power consumption core circuit across entire output frequency range
work versatile user friendly selection stereolithography stl files computer aided design cad models shared assist educators students production simple inexpensive printed filter fluorometer instruments devices effective resources supporting active learners exploration instrument design performance contrast sophisticated commercial grade fluorometers models provided open source customizable variety applications easily assembled students activities directly confront black box perception analytical instrumentation order aid beginner cad printer users models compatible accessible software packages design inventor professional additionally cad tutorials extensive slicer settings supplied assist educators students modifying digital designs obtaining reliable prints provided filter fluorometer models printed quickly consume dollar worth plastic require complex support structures printed fabricated assembled devices perform well range laboratory activities including quantitative determination luminescent analytes ppm ppb level
background small size focus breast magnetic resonance imaging mri must evaluated basis characteristics morphologic features patient related factors including patient age conjunction lesion related factors could useful decision making purpose assess probability malignant foci based lesion patient related factors propose relevant decision making method material methods foci breast mri database dating april june retrospectively identified analyzed fisher exact test mann whitney test performed univariate analyses factors showed significant association outcome univariate analyses subjected multivariate analysis using logistic regression model decision tree drawn using significant predictors confirmed multivariate analysis results total foci benign malignant patients analyzed study presence washout pattern older age found significant predictors malignancy years conclusion enhancing focus showing washout pattern especially older patients may warrant immediate biopsy rather short interval follow
determine focal increased uptake rotator interval inferior capsule fdg pet positive pet predicts presence adhesive capsulitis three populations retrospectively examined group included consecutive fdg pet studies used determine prevalence focal uptake group included cases year period fdg pet mri shoulder performed within days used enrich study group group included randomly selected patients time frame groups used generate control group study group consisted cases three groups positive pet findings pet images assessed consensus two musculoskeletal radiologists reference standard diagnosis clinical made review medical record pain medicine physician prevalence focal activity either positive pet nine patients clinical diagnosis patients positive pet sensitivity specificity pet detection respectively pet positive likelihood ratio increased uptake pet confers moderate increase likelihood
partial bladder outlet obstruction pboo usually induces overactive bladder oab associated detrusor overactivity related increased contractility detrusor smooth muscle dsm pharmacological activation small conductance activated channels dramatically attenuates dsm contractility however role channels pboo dsm less clear tested hypothesis pboo associated decreased expression function channels dsm activation channels potential target regulate two weeks surgically inducing pboo female guinea pigs cystometry indicated achieved using animal model conducted quantitative reverse transcription polymerase chain reaction qrt pcr isometric tension recordings qrt pcr experiments indicated pboo dsm reduced channel mrna expression isometric tension recordings showed decreased inhibitory effect spontaneous phasic electrical field stimulation induced contractions via activation channels pboo dsm study presents novel finding pboo associated attenuated dsm channel expression function results increased dsm contractility contributes therefore channels could therapeutic target control oab
four studies tested hypothesis weaker belief free would related feeling less gratitude studies trait measure free belief positively correlated measure dispositional gratitude study participants whose free belief weakened unchanged bolstered reported feeling less grateful events past study used laboratory induction gratitude participants experimentally reduced increased belief free reported feeling less grateful favor study reduced increased belief free led less gratitude hypothetical favor scenario effect serially mediated perceiving benefactor less free therefore less sincerely motivated findings suggest belief free important part able feel gratitude
nonlinear regression choosing adequate model structure often challenging problem simple models linear functions may able capture underlying relationship among variables parametrized models described large set nonlinear basis functions tend overfit training data leading poor generalization unseen data piecewise affine pwa models describe nonlinear possible discontinuous relationships maintaining simple local affine regressor output mappings extreme flexibility polyhedral partitioning regressor space learned data rather fixed priori paper propose novel numerically efficient two stage approach pwa regression based combined use recursive multi model least squares techniques clustering fitting linear functions data linear multi category discrimination either offline batch via newton like algorithm computing solution unconstrained optimization problems objective functions piecewise smooth gradient online recursive via averaged stochastic gradient descent elsevier ltd rights reserved
humans organisms adapted consistent predictable solar cycle past similar years widespread adoption electric light transformed environment instead aligning behavioral physiological processes natural solar cycle individuals respond artificial light cycles created social work schedules urban light pollution night shift work transmeridian travel televisions computers dramatically altered timing light used entrain biological rhythms humans mammals light detected retina intrinsically photosensitive retinal ganglion cells project information circadian system limbic brain regions therefore possible exposure light night become pervasive may disrupt circadian timing mood notably rate major depression increased recent decades parallel increasing exposure light night strong evidence already links circadian disruption major depression mood disorders emerging evidence past years suggests exposure light night also negatively influences mood review discuss evidence recent human rodent studies supporting novel hypothesis nighttime exposure light disrupts circadian organization contributes depressed mood
people working capability badly affected suffer amputated arm artificial replacements prosthetic devices get satisfactory level performance essential functions currently available prosthetic technology difficult myoelectric arm prostheses becoming popular operated natural contraction intact muscles hence semg based artificial arm fabricated system consists different electronic mechanical assemblies operation hand utilizing microcontroller order minimum signal loss processing help relay switching connected low power motor system capable opening closing grip according individual wish
gps radio occultation estimate ionospheric electron density total electron content tec high spatial resolution china recent fengyun gps radio occultation however high order ionospheric delays normally ignored paper high order ionospheric effects electron density estimation fengyun gps radio occultation data estimated investigated using nequick ionosphere model igrf international geomagnetic reference field generation geomagnetic model results show high order ionospheric delays large effects electron density estimation corrected high precision ionospheric density estimation applications second order ionospheric effects significant particularly third order ionospheric effects much smaller furthermore high order ionospheric effects related location local time radio occultation azimuth solar activity large high order ionospheric effects found low latitude area daytime well strong solar activities second order ionospheric effects maximum positive value radio occultation azimuth around degrees maximum negative value radio occultation azimuth around degrees moreover geomagnetic storm also affects high order ionospheric delay carefully corrected
recently quantum inf process proposed first semi quantum scheme without need classical channel generate secret key employing master key entanglement properties bell states study points vulnerability allows malicious person recover partialmaster key launch successful man middle attack accordingly present likely leakage information scenarios outside attacker affects security proposed protocol
global south gender roles relations closely connected water collection use aim article move beyond simple development associations linking improved water access women empowerment showing gender roles marital relations division labor connected everyday water practices ethnographic research took place five communities nampula mozambique year residents endured seasonal dry months later received water supply project research explores gender roles relations impacted changes community water resources impacts understood local perspectives rural mozambique water collection use gendered activities also practices shape marital relations cultural notions good wife mother
background dental health care professionals play important role mandated advocates health care neglect suspected children however confusion around constitutes child neglect methods authors reviewed dental literature descriptors definitions neglect studied individual state statutes learn protection afforded victims neglect health care providers acting behalf children also reviewed methods action address suspected neglect results authors found confusion around child neglect yet dental professionals tasked law moral code protect children neglect authors offer definition neglect suggested practice guidelines assist practitioner acting child advocate conclusions clinicians use strategies address problem child neglect digital data treatment registry may provide additional views child health status practical implications better understanding definition neglect strategies implemented use dental team address problem neglect reduce incidence
mammalian genomes scattered thousands copies endogenous retroviruses ervs mobile genetic elements relics ancient retroviral infections inserting copies germ line host ervs accumulate mutations prevent normal assembly infectious viral particles becoming trapped host genomes unable leave infect cells copies ervs inactive transcribed encode proteins needed generate new insertions novel loci cases old copies removed via recombination mechanisms creates shifting landscape erv copies within host genomes new insertions disrupt normal expression nearby genes via directly inserting key regulatory elements containing regulatory motifs within sequences transcriptional silencing ervs via epigenetic modification may result changes epigenetic regulation adjacent genes ways ervs potent sources regulatory disruption well genetic innovation provide brief review association ervs gene expression especially observed pre implantation development placentation moreover describe disruption regulated mechanisms ervs may impact somatic tissues mostly context human disease including cancer neurodegenerative disorders schizophrenia lastly discuss recent discovery ervs may pressed service host genomes aid innate immune response exogenous viral infections
paper shows wien bridge oscillator always sinusoidal oscillator depending differential input voltage operational amplifier used output wien bridge oscillator move nearly sinusoidal wave nearly square wave depends largely values passive components used experimental results confirms presented theory included results confirm previously made observations sinusoidal oscillators multivibrators separate classes circuits circuit provide two modes operation depending values passive components used
background many immigrant ethno cultural groups canada face substantial barriers accessing health care including language barriers negative consequences miscommunication health care settings well documented although little research communication barriers facing immigrant women seeking maternity care canada study identified nature communication difficulties maternity services perspectives immigrant women health care providers social service providers small city southern alberta canada methods focused ethnography undertaken incorporating interviews participants recruited using purposive snowball sampling community liaison several gatekeepers within community assisted recruitment interpretation needed interviews recorded audio files transcribed verbatim professional transcriptionist data analysed drawing upon principles expounded roper shapira analysis ethnographic data relevance ethnographic data clarity transparency approach systematic approach analysis compatibility approach computer assisted qualitative analysis software programs atlas atlas scientific software development gmbh germany process included coding descriptive labels sorting patterns identification outliers generation themes generalising generate constructs theories memoing including researcher reflections findings four main themes identified including verbal communication unshared meaning nonverbal communication build relationships trauma culture open communication communication difficulties extended beyond matters language competency encompassing nonverbal communication relation shared meaning well interplay underlying pre migration history cultural factors affect open communication accessible health care perhaps also maternal outcomes conclusion study provided insights regarding maternity health care communication communication challenges may experienced parties yet onus remains health care providers within health care management professional bodies ensure providers equipped skills necessary facilitate culturally appropriate care elsevier ltd rights reserved
approximate adders widely advocated means achieve performance gain error resilient applications paper generic methodology analytical modeling probability occurrence error probability mass function pmf error value selected class approximate adders presented serve performance metrics comparative analysis various adders configurations proposed model applicable approximate adders comprise sub adder units uniform well non uniform lengths using systematic methodology derive closed form expressions probability error number state art high performance approximate adders probabilistic analysis carried arbitrary input distributions used study dependence error statistics adder output configuration input distribution moreover shown building upon proposed error model estimate probability error circuits multiple approximate adders also demonstrate using proposed analysis comparative performance different approximate adders correctly predicted practical applications image processing
migraine stroke common disabling neurologic disorders high socioeconomic burden link proposed years ago various theories proposed explain bidirectional relation however precise causes remain unclear briefly summarize existing hypotheses correlation seeking recommendations stroke prevention migraineurs exist among strongest suggested theories migraine stroke association cortical spreading depression endovascular dysfunction vasoconstriction neurogenic inflammation hypercoagulability increased prevalence vascular risk factors shared genetic defects cervical artery dissection patent foramen ovale evidence preventive therapy migraineurs used decrease stroke risk even predisposed subset patients however woman migraine aura encouraged cease smoking avoid taking oral contraceptives high estrogen doses need investigation better understand complexity migraine stroke association make firm recommendations future
indications vagus nerve stimulation vns therapy include focal multifocal epilepsy drop attacks tonic atonic seizures lennox gastaut syndrome tuberous sclerosis complex tsc related multifocal epilepsy unsuccessful resective surgery surgical outcome seizures control may also improve mood cognition memory basis vns also proposed treatment major depression alzheimer disease vagus nerve stimulator must implanted blunt technique left side avoid cardiac side effects classic approach anterior cervical discectomy actual device composed wire three helical contacts two active contacts one anchoring one pin battery vns usually started weeks implantation recommended settings stimulation pulse width min complications vns therapy early related surgery late related device stimulation vagus nerve early complications include following intraoperative bradycardia asystole lead impedance testing peritracheal hematoma infections vagus nerve injury followed hoarseness dyspnea dysphagia left vocal cord paralysis delayed morbidity due device includes late infections problems wound healing rare events due late injury nerve late complications due nerve stimulation include delayed arrhythmias laryngopharyngeal dysfunction hoarseness dyspnea coughing obstructive sleep apnea stimulation phrenic nerve tonsillar pain mimicking glossopharyngeal neuralgia vocal cord damage prolonged endotracheal intubation laryngopharyngeal dysfunction occurs patients usually transitory due stimulation inferior recurrent laryngeal nerve true late paralysis left vocal cord often partial rare usually transitory may caused previous surgical trauma damage nerve fibers blood supply supposed chronic denervation stimulation surgery complete removal revision replacement device considered cases device malfunction failure vns therapy intolerable side effects patient specific request described literature surgical techniques lead revision replacement two sharp blunt dissection helical electrodes replacement blunt dissection combined ultrasharp low voltage cautery dissection incidence left vocal cord palsy vagus nerve stimulator replacement revision slightly higher first implantation novo implantation naive segment left right vagus nerve may considered specific cases use right vagus nerve rare exception may chosen acceptable result
background key driver human autoimmune diseases particularly psoriasis objective sought determine role psoriasis pathogenesis identify robust measurable biomarker driven pathology methods studied healthy subjects patients psoriasis administration secukinumab fully human anti mab used combination classical techniques novel skin microperfusion assay evaluate expression proteins blood nonlesional skin lesional skin validation also tested stored sera patients variety autoimmune diseases results specifically expressed lesional compared nonlesional psoriatic skin proteomic gene transcription analyses revealed dysregulated antimicrobial peptides proinflammatory cytokines neutrophil chemoattractants levels returned normal treatment secukinumab beta defensin identified biomarker driven pathology comparing protein expression patients psoriasis versus healthy subjects serum dermis responsiveness secukinumab therapy synergistic induction tnf alpha epidermal keratinocytes validation set sera patients autoimmune diseases thought driven found levels highly increased patients psoriatic skin lesions patients psoriasis levels correlated well levels psoriasis area severity index scores conclusion primary driver skin pathology patients psoriasis serum easily measurable biomarker driven skin pathology
school timetabling classic optimization problem extensively studied due practical theoretical importance consists scheduling set class teacher meetings predetermined period time satisfying requirements different types given combinatorial nature problem solving medium large instances timetabling optimality challenging task resources tight often difficult find even feasible solution several techniques developed literature tackle high school timetabling problem since use exact methods mathematical programming techniques considered impracticable solve large real world instances metaheuristics hybrid metaheuristics used solution approaches paper propose multi commodity flow model high school timetabling problem addition apply dantzig wolfe decomposition proposed model propose column generation algorithm present experimental results well known instances problem results show lower bounds obtained approach tight generated faster previous approaches reported literature elsevier rights reserved
prostaglandin pge natural lipid derived molecule involved important physiological functions abnormal pge signalling associated pathologies nervous system previous studies provide evidence interaction pge canonical wnt signalling pathways non neuronal cells since wnt pathway crucial development organization brain main goal study determine whether collaboration pathways exists neuronal cell types report pge interacts canonical wnt signalling pka neuroectodermal stem cells used time lapse microscopy determine pge increases final distance origin path length travelled average speed migration wnt activated cells furthermore pge alters distinct cellular phenotypes characteristic wnt induced cells corresponds modified splitting behaviour cells also found wnt induced cells level beta catenin protein increased expression levels wnt target genes ctnnb ptgs ccnd mmp significantly upregulated response pge treatment confirms pge activated canonical wnt signalling pathway furthermore upregulated genes previously associated asd findings show first time evidence cross talk pge wnt signalling neuronal cells pka might act mediators two pathways given importance pge wnt signalling prenatal development nervous system study provides insight interaction two pathways may influence neurodevelopment
myelodysplasia myeloid leukemia factor interacting protein mlfip appears erythroid lineage specific gene mice however role normal erythropoiesis erythropoietic disorders yet elucidated found mlfip abundantly expressed human erythroid progenitor cells mlfip deficiency reduces cell proliferation resulting cell cycle arrest moreover mlfip expression exclusively elevated cfu cells polycythemia vera patients mlfip transgenic mice develop like disorder analyses revealed erythroid progenitors early stage erythroblasts transgenic mice expand regulating cyclin regulating thus data demonstrate mlfip promotes erythroid proliferation involved pathogenesis suggesting might novel molecular target erythropoietic disorders
game science become research field attracts industry attention due worldwide rich sell market understand player experience concepts like flow boredom mental states require formalization empirical investigation taking advantage objective data psychophysiological methods like electroencephalography eeg provide work studies affective ludology shows two different game levels neverwinter nights developed aim manipulate emotions two sets affective design guidelines presented rigorous formalization considers characteristics role playing genre specific gameplay empirical investigation brain computer interface headset conducted extracting numerical data features machine learning techniques classify different activities gaming sessions task events verify design differentiation coincides affective one observed results also supported subjective questionnaires data confirm goodness proposed guidelines suggesting evaluation methodology could extended evaluation tasks
paper mandarin text speech tts technique employed achieve implementation voiced book pic based embedded platform transformation text book corresponding speech help blind users make reading effortless relaxed microcontroller pic ethernet starter kit mhz bit sram flash multimedia expansion board designed microchip technology inc adopted embedded platform four subsystems namely text analysis recurrent neural network based prosodic generator synthesis unit generator chinese syllabic waveforms pitch synchronous overlap add based speech synthesizer made mandarin tts system implemented programming language experimental results find system requirement storage memory less runtime memory well cpu runtime sufficient real time operation natural fluent speech bit pcm khz sampling rate provided performance pic based mandarin tts system demonstrated good institute electrical engineers japan published john wiley sons inc
schizophrenia heterogeneous disorder psychiatric symptoms classified two general subgroups positive negative symptoms current antipsychotic drugs effective treating positive symptoms whereas negative symptoms less responsive since neuropeptide oxytocin shown mediate social behavior animals humans used experimental therapeutic treating schizophrenia particular negative symptoms includes social deficits eight randomized controlled trials rcts three meta analyses evidence effect intranasal inconsistent therefore conducted updated meta analysis offers several advantages compared done previously used multivariate analysis allows comparisons symptoms accounts correlations symptoms controlled baseline scores used fully bayesian framework allows assessment evidence favor null hypothesis using bayes factors addressed inconsistencies primary studies previous meta analyses eight rcts included present study found oxytocin improve aspect symptomology schizophrenic patients moderate evidence favor null effect oxytocin negative symptoms multivariate comparisons symptom types revealed oxytocin especially beneficial treating negative symptoms effect size estimates moderated publication bias absent estimates robust sensitivity analyses results suggest effective therapeutic schizophrenia elsevier ltd rights reserved
architectural performance comparison bandgap voltage reference variants designed cmos process performed respect single event transients commonly induced microelectronics space radiation environment heavy ion tests silicon krypton xenon used explore analog single event transients revealed pulse quenching mechanisms analogue circuits different topologies compared terms cross section pulse duration pulse amplitude measured results explanations behind findings reveal important guidelines designing analog integrated circuits intended space applications paper includes analysis pulse quenching occurs within indispensable current mirror used every analog circuit
context research shown majority real faults complex simulated traditional first order mutants foms higher order mutants homs created making multiple syntactic changes source code combining multiple foms potentially used simulate realistic faults objective goal find subtle homs define homs killed reference test suite kills foms subtle homs represent cases single faults interact masking produce complex faulty behavior fault detection effectiveness test suite improved adding test cases detect subtle homs method developed six search based techniques find subtle homs genetic algorithm local search data interaction guided local search test case guided local search restricted random search restricted enumeration performed empirical studies evaluate ability search techniques find subtle homs investigated factors impact characteristics subtle homs results local search guided local search techniques effective techniques finding subtle homs majority subtle homs found resulted combining mutated java primitive operators conclusions proposed techniques able find subtle homs composing subtle homs lower degrees effective way finding new subtle hom higher degrees elsevier rights reserved
recently yang hwang int theor phys demonstrated scheme share information via employing discrete algorithm quantum states presented kang fang commun theor phys suffers major vulnerability allowing eavesdropper perform measurement resend attack introducing additional checking state framework authors proposed improved protocol overcome weakness work calls question invoked vulnerability order clarify misinterpretation protocol stages also introduce possible leakage information strategy known faked state attack despite proposed improvement means security problem may persist finally upgrading technic introduced order enhance security transmission
abnormal regulation immune responses leads autoimmune inflammatory manifestations patients primary immunodeficiencies pids objective study evaluate frequency non infectious non malignant manifestations large cohort patients included slovenian national pid registry assess time manifestation onset respect time pid diagnosis medical records registered patients reviewed data autoimmunity lymphoproliferation autoinflammation allergies pid diagnosis underlying genetic defects collected analyzed time manifestation onset determined compared time pid diagnosis may patients different pids registered slovenian national pid registry males females mean age years mean disease duration years patients younger years patients adults diagnosis pid genetically confirmed patients non infectious non malignant manifestations present patients including autoimmune manifestations lymphoproliferative granulomatous autoinflammatory allergic manifestations registered patients autoimmune manifestations present patients whose pids classified diseases immune dysregulation patients chronic granulomatous disease patients predominantly antibody immune deficiencies high prevalence non infectious non malignant manifestations among patients slovenian national pid registry suggests common genetic factors autoimmunity inflammation immunodeficiency patients pid routinely screened autoimmune inflammatory manifestations time pid diagnosis long term follow
continuous research effort worldwide improve reliability efficiency accuracy numerical computations various domains one promising research avenues exploit structural properties mathematical problems solved paper investigates numerical algorithms solution common structured eigenproblems many applications automatic control linear quadratic optimization infinity optimization also various areas applied mathematics physics computational chemistry much interest find eigenvalues certain deflating sub spaces mainly associated stable eigenvalues several simple examples used highlight pitfalls may appear numerical computations using state art solvers balancing matrices use condition numbers eigenvalues shown essential options investigating behavior solvers problem sensitivity
battery free wireless neural probe system developed reading neural signals brain using one port surface acoustic wave saw reflective delay line neural firing dependent varicap diode two antennas network analyzer measurement unit one port saw reflective delay line replaces existing complex wireless transceiver system composed similar electronic components makes battery free wireless measurements possible varicap diode interconnected sharp metal shank via operational amplifier amp electrically linked corresponding split type reflectors one port saw reflective delay line inductor also placed split type reflector one port saw reflective delay line varicap diode obtain large linearity high sensitivity impedance matching effect electrical pulses imitating neural signals applied sharp metal shanks overall impedance perturbations split type reflector external varicap diode reverse bias observed giving rise amplitude changes reflection peaks time domain depending magnitude electrical pulses good linearity sensitivity observed amplitude variations terms electrical pulses coupling modes com modeling impedance matching simulations also performed predict device performances compare experimental results elsevier rights reserved
newly licenced drivers disproportionately represented traffic injuries crash statistics despite implementation countermeasures designed improve safety graduated driver licencing gdl schemes many young drivers comply road rules study used reconceptualised deterrence theory framework investigate young drivers perceptions enforcement road rules general specifically related gdl total drivers aged completed questionnaire assessing perceptions various deterrence mechanisms personal vicarious compliance gdl specific general road rules hierarchical multiple regressions conducted explore noncompliant behaviour revealed contrary theoretical expectations neither personal vicarious punishment experiences affected compliance expected direction instead influential factors contributing noncompliance licence type counterintuitively previously exposed enforcement parental enforcement also significant prediction transient rule violations fixed rule violations overall noncompliance findings discussed light several possibilities including increase violations due time spent road emboldening effect noted prior studies possible conceptual constraints regarding deterrence variables examined study
speech associated gesturing leads memory advantages spoken sentences however unexpected surprising events also likely remembered study test hypothesis different neural mechanisms semantic elaboration surprise lead memory advantages iconic unrelated gestures fmri data acquisition participants presented video clips actor verbalising concrete sentences accompanied iconic gestures circular gesture sentence man sitting round table unrelated free gestures unrelated movements sentence gestures sentence scanning recognition performance three conditions tested videos evaluated regarding semantic relation surprise different group participants semantic relationship speech gesture rated higher whereas surprise rated higher activation hippocampus correlated subsequent memory performance gesture conditions condition found activation left temporal pole middle cingulate cortex mcc contrast condition posterior thalamic structures well anterior posterior cingulate cortices activated behavioral fmri data suggest different mechanisms processing related unrelated verbal gestures leading enhanced memory performance whereas activation mcc left temporal pole iconic verbal gestures may reflect semantic memory processes memory enhancement unrelated gestures relies surprise response mediated anterior posterior cingulate cortex thalamico hippocampal structures elsevier rights reserved
purpose study carry thorough critical analysis morison equation far calculating wave action large diameter piles like used nowadays offshore wind farms concerned aim observe whether models currently used estimate wave forces piles valid large diameter piles apart observing main forces play scouring equation enables wave produced forces cylinder supported sea bed calculated study includes observations calculation model sensitivity variation cylinder diameter one hand temperature salinity variation mind specific software developed simulate equations fluid mechanics applied solve wave structure interaction problem separation inertial diffraction range software enable iterative calculation made finding shape pressure wave caused wave passes show results different pile diameters water temperature
background studies examining female sexual functions fsfs used cross sectional designs allowing studying temporal stability possible relationships different fsfs time aim study relationships using longitudinal approach method study sample consisted finnish women two large scale population based data collections years apart female sexual function index used analyses conducted separately women different relationship constellations results standardized autoregressive paths ranged sexual satisfaction orgasm function full sample suggesting variance fsf explained something previous function orgasm desire satisfaction strongest predictors functions full sample women relationship time points higher orgasm function predicted higher function domains greater sexual desire satisfaction predicted lower function domains however small effects sizes single women orgasm function sexual desire significant autoregressive paths significant unidirectional cross domain paths found women relationship time points one significant cross domain path confirmed unidirectional found single women conclusions fsfs varied considerably years relationship status importance assessing temporal stability cross domain effects results advocate tailored psychobehavioural treatment interventions female sexual dysfunctions take partner specific factors account
paper deals application fractional derivatives modeling electrical circuits rlc power electronic devices nonlinear loads equations obtained replacing time derivative fractional derivatives type riemann liouville grfinwald letnikov liouville caputo fractional definition recently introduced caputo fabrizio fractional equations time domain considers derivatives range alpha element analytical numerical results presented considering different source terms introduced fractional equation resulting solutions modified capacitance inductance also resistance exhibits fluctuations fractality time different scales furthermore results showed existence heterogeneities electrical components causing irreversible dissipative effects classical models recovered order fractional derivatives equal elsevier inc rights reserved
paper presents investigation mediating roles mood perception subjects cognitive performance daylit workplace hypothesized various daylighting conditions would affective sources convey emotional meanings room occupants thus affect behaviors carried series controlled experiments sunlit work setting subject comparisons among ten groups seated different spots sunlit room suggested lighting non lighting factors simultaneously influence subjects mood correlated performance moderate amounts sunlight view together sense control privacy positively affected subjects mood negatively affected increased difficulty assigned cognitive tasks
agricultural research community offers languages approaches model farmers decision making processes often clearly detail steps necessary build agent model underlying farmers decision making processes propose original readily applicable methodology modelers guide data acquisition analysis incorporate expert knowledge conceptualize decision making processes farming systems using software engineering language support development model propose step step approach combines decision making analysis modeling approach inspired cognitive sciences software development methods methodology starts case based analysis study determine complexity decision maloing processes provide tools obtain generic conceptual model decisional agent studied farming system generic farm representation decision diagrams obtained cross case analysis modeled unified modeling language applied methodology research question water management emerging country india methodology bridges gap field observations design decision model useful tool guide modelers building decision model farming system elsevier ltd rights reserved
continental scale water quality modeling new scientific approach concerned computing level water pollution several river basins uncertainties models models smaller scale arise especially specification model parameters identify analyze uncertainties perform global sensitivity uncertainty analysis using latin hypercube sampling worldqual water quality model focus analysis river pathogen model worldqual applied rivers africa first uncertainty sensitivity analysis performed continental scale pathogen river pollution model median output uncertainty model coefficient variation based log transformed data assuming plausible estimates parameter uncertainties grid cells output uncertainties parameters making largest contribution uncertainty order importance pathogen waste loading per capita stream settling velocity pathogens percentage population river basin connected sewer system raw effluent concentration manufacturing sector continental study area model output uncertainty sensitive parameters found highly irregular spatial pattern finding suggests model performance strong function local regional conditions reducing uncertainty single parameter may lead large improvements model performance entire continent efficient approach would improve model performance region region improve estimation specific parameters known large influence model uncertainty regions analysis showed four parameters dominate output uncertainty study area implying model performance substantially improved reducing uncertainty small number parameters elsevier rights reserved
objective examine trajectories responses acupuncture treatment menopausal vasomotor symptoms vms characteristics women trajectory methods two hundred nine perimenopausal postmenopausal women aged years experiencing least four vms per day recruited randomized receive acupuncture treatments within months waitlist control group primary outcome percent change baseline mean daily vms frequency finite mixture modeling used identify patterns percent change weekly vms frequencies first weeks freeman holton test analysis variance used compare characteristics women different trajectories results analyses revealed four distinct trajectories change vms frequency week acupuncture group small group women reduction vms largest group reported reduction vms frequency sample showed reduction vms frequency small group increase vms among women waitlist control group reported decrease vms frequency week baseline number vms number acupuncture treatments first weeks traditional chinese medicine diagnosis significantly related trajectory group membership acupuncture group conclusions approximately half treated sample reported decline vms frequency identifying clear predictors clinical response acupuncture treatment menopausal vms remains challenging
rapid development computer technology people pay attention security computer data computer virus become chief threat computer data security using antivirus system identify randomly generated computer viruses basis basic characteristics computer code paper investigates heuristic scanning technique paper proposes minimum distance classifier detection model analysis malicious code model identify unknown feature codes illegal procedures construct healthy network environment using combination model experimental method intercept illegal virus program installation operation stages elsevier rights reserved
phlebotomy removal blood body therapeutic phlebotomy preferred treatment blood disorders removal red blood cells serum iron efficient method managing symptoms complications therapeutic phlebotomy currently indicated treatment hemochromatosis polycythemia vera porphyria cutanea tarda sickle cell disease nonalcoholic fatty liver disease hyperferritinemia review discusses therapeutic phlebotomy related disorders also offers guidelines establishing therapeutic phlebotomy program
paper study resource allocation multiuser multiple input single output secondary communication systems multiple system design objectives consider cognitive radio networks secondary receivers able harvest energy radio frequency idle secondary system provides simultaneous wireless power secure information transfer secondary receivers propose multiobjective optimization framework design pareto optimal resource allocation algorithm based weighted tchebycheff approach particular algorithm design incorporates three important system design objectives total transmit power minimization energy harvesting efficiency maximization interference power leakage transmit power ratio minimization proposed framework takes account quality service qos requirement regarding communication secrecy secondary system imperfection channel state information csi potential eavesdroppers idle secondary receivers primary receivers secondary transmitter proposed framework includes total harvested power maximization interference power leakage minimization special cases adopted multiobjective optimization problem nonconvex recast convex optimization problem via semidefinite programming sdp relaxation shown global optimal solution original problem constructed exploiting primal dual optimal solutions sdp relaxed problem moreover two suboptimal resource allocation schemes case solution dual problem unavailable constructing optimal solution proposed numerical results demonstrate close optimal performance proposed suboptimal schemes unveil interesting tradeoff among considered conflicting system design objectives well
following call investigate whether theory leadership could applicable temporary organizations research examined associations among transformational leadership tfl subordinate work engagement weg project turnover intention pti project settings addition subordinate identification project proposed social identity mechanism transformational project managers exert influence subordinate work outcomes model tested based data collected sample employees working infrastructure projects located china transformational leadership found positively relate subordinates work engagement negatively relate subordinates project turnover intentions furthermore project identification completely mediates tfl weg relationship whereas partially mediates tfl pti relationship findings contribute literature extending extant transformational leadership approaches context temporary organization broadening leadership research conjunction social identity theory elsevier ltd apm ipma rights reserved
laparoscopic sleeve gastrectomy lsg laparoscopic greater curvature plication lgcp two restrictive bariatric procedures eight studies three randomized controlled trials four retrospective studies one prospective study patients lsg lgcp included searching pubmed embase cochrane library software review manager used evaluate operation time adverse events percent excess weight loss ewl resolution obesity related comorbidities postoperative hospital stay despite limitations meta analysis suggests lsg superior lgcp terms providing greater ewl follow months years lsg gains shorter postoperative hospital stay lgcp significant difference found operation time adverse events resolution obesity related comorbidities
concept reversible heat exchange process theoretical model cycle combined heat exchanger could useful determine thermodynamics characteristics limitation values isolated heat exchange system study classification reversible heat exchange processes presented numerical method medium temperature variation tendency useful work production usage whole process investigated construction solution mathematical descriptions various values medium inlet temperatures heat capacity ratio considered analyze effects process parameters outlet temperature lift drop maximum process work transferred carnot cycle region reverse cycle region also researched moreover influence separating point different sub processes temperature variation profile process work production analyzed addition heat exchange enhancement factor defined study enhancement effect application idealized process isolated heat exchange system variation degree factor process parameters change obtained research results paper theoretical guidance construct cycle combined heat exchange process practical system elsevier ltd rights reserved
paper proposes technique mitigating issue reduced signal voltage range existing analog signal processing circuits finer technologies due low supply voltage proposed adaptively biased mosfet pair make mosfet operate saturation triode region wider voltage range simulated results source coupled pair proposed structure using cadence spectre mosfet parameter cmos technology also presented
shannon proposed question quantification structural information analyze communication systems question become one longest great challenges information science computer science propose first metric structural information given graph define dimensional structural information structure entropy denoted minimum overall number bits required determine dimensional code node accessible random walk dimensional structural information provides principle completely detecting natural true structure consists rules regulations orders graphs fully distinguishing order disorder structured noisy data analyzing communication systems solving shannon problem opening new directions dimensional structural information also first metric dynamical complexity networks measuring complexity interactions communications operations even evolution networks metric satisfies number fundamental properties including additivity locality robustness local incremental computability establish fundamental theorems one two dimensional structural information networks including lower upper bounds metrics classic data structures general graphs networks models networks natural evolution propose algorithms approximate dimensional structural information graphs finding dimensional structure graphs minimizes dimensional structure entropy find dimensional structure entropy minimization principle detecting natural true structures real world networks consequently structural information provides foundation knowledge discovering noisy data establish black hole principle using two dimensional structure information graphs propose natural rank locally listing algorithms structure entropy minimization principle providing basis next generation search engine
little known pocket oop costs incurred medical health needs rural breast cancer survivors factors may associated higher oop costs associated economic burden data examined survivors participating rural breast cancer survivor intervention trial oop costs collected using work finances inventory survey baseline four assessments every months mean median oop costs burden percent monthly income spent oop costs reported factors associated oop costs burden identified generalized linear models fitted dispersed gamma distributions logarithmic links oop costs beta distributions logit link oop burden oop costs per month since end treatment average median declined next assessment point median thereafter remained level mean oop burden baseline next assessments factors suggestive contributing higher oop costs oop burden following younger age lower income time survivorship diagnosis use supportive services oop costs burden rural breast cancer survivors particularly younger low income research investigate impact oop costs interventions reduce economic burden
severe appetite weight loss define eating disorder anorexia nervosa also accompany progression neurodegenerative disorders amyotrophic lateral sclerosis als although acute loss hypothalamic neurons produce appetite stimulating neuropeptide npy agouti related peptide agrp adult mice mice homozygous anorexia anx mutation causes aphagia understanding factors help maintain appetite regulatory circuitry limited identify mutation converts arginine tryptophan tyro protein tyrosine kinase tyro gene resides within anx critical interval contributing severity anx phenotypes observation like tyro mice anx anx mice exhibit abnormal secondary platelet aggregation suggested tyro variant might functional consequences tyro expressed hypothalamus brain regions affected anx mutation mrna localization appeared abnormal anx anx brains postnatal day presence wild type tyro transgenes tyro transgene doubled weight lifespans anx anx mice near normal numbers hypothalamic npy expressing neurons present tyro transgenic anx anx mice although differences tyro signal sequence function protein localization discernible vitro distribution tyro protein differed tyro protein cerebellum transgenic wild type mice thus tyro protein localization deficits detectable vivo analyses revealed tyro mutation present mouse strains hence causative anx mutation rather anx modifier work shows tyro prosurvival roles appetite regulatory circuitry could also provide useful insights towards development interventions targeting detrimental weight loss
hierarchical search structures satisfying good memory update performance demands encouraging solution packet classification multi core processors however pipelined hardware implementation algorithms two major issues backtracking causes stalling pipeline memory inefficiency owing variation size trie nodes paper present clustering algorithm named recursive leaf extraction rle partitions input ruleset certain number sub rulesets eradicate backtracking hierarchical search structures enhanced rle method proposed optimized rle rle algorithm balance size clusters additionally present ternary trie data structure epsilon takes advantage epsilon branch property segment large trie nodes fixed size epsilon nodes solve memory inefficiency problem propose two hierarchical data structures denoted tree trie epsilon epsilon extended version tree trie epsilon linked list epsilon epsilon consists binary search tree stage multiple epsilon structures stage epsilon comprises additional linked list data structure stage maintains large portion nodes thus freely optimizes search delay significant improvement memory efficiency bytes rule accommodate proposed data structures designed high throughput sram based parallel pipelined architectures field programmable gate arrays fpgas gbps elsevier rights reserved
objective general agreement patient education essential compliance objective tools exist assess knowledge children parents children endocrine disorders aimed design validate pediatric endocrine knowledge assessment questionnaire pekaq congenital hypothyroidism hashimoto thyroiditis isolated growth hormone deficiency graves disease congenital adrenal hyperplasia evaluated baseline knowledge children parents children disorders assessed impact educational intervention methods baseline children years parents children years participated prospective intervention study educational handouts five targeted disorders designed following one one educational intervention children parents participated baseline post intervention knowledge scores compared using mcnemar test results adequate multi rater kappa measure agreement achieved children parent pekaqs flesch reading ease score pekaqs questions post intervention significantly higher proportion parents children answered majority questions correctly sixteen percent parents children knew diagnosis correctly significant improvement noted among participants regarding reason treatment steps take situation missed dose exercise diet disorders long term prognosis parent knowledge score independent predictor child score conclusions knowledge first validated pekaq used widely pediatric endocrinology clinics noted significant improvement knowledge children parents children endocrine disorders
stability power converters become important hybrid green energy systems difficulties maintain stable bus paper presents dynamic characteristics digital integral gain changeable control converter realize high stability suppression output capacitance integral gain changeable control method uses variable integral gain changed value load current stability analysis conducted bode diagrams shown transient response stability integral gain changeable method better conventional fixed integral gain control method even output capacitance smaller conventional method simulation experimental results show effectiveness concept
novel configuration current mirrors differentiators based continuous time current mode low pass filter proposed paper filter consists current mirrors differentiators capacitors topology really simple sensitivity low suits full integration computer simulation transistor carried results show proposed circuits effective
neuropeptide oxytocin known play pivotal role variety complex social behaviors promoting prosocial attitude interpersonal bonding one mechanism hypothesized promote prosocial behavior enhancing processing socially relevant information environment present study explored extent alter reading emotional body language presented impoverished biological motion point light displays plds double blind subjects randomized placebo controlled trial conducted assessing performance bodily emotion recognition task healthy adult males single dose intranasal overall single dose administration significant effect medium size emotion recognition body language induced improvements emotion recognition differentially modulated emotional valence presented stimuli positive versus negative also overall tendency label observed emotional state happy positive angry negative modified administration albeit moderate present findings induced improvements bodily emotion recognition whole body pld provide support link processing socio communicative cues originating body others authors published elsevier ltd
green energy gained significant research attention across globe due ability reduce environmental damage however complete acceptance green energy government regulations enough willingness use green energy contribute wellbeing environment spring within consumers willingness may developed enhancing consumers perceived value green energy however order necessary assess existing levels consumers perceived value towards green energy present study develops multidimensional green perceived value scale measure existing levels consumers perceived value scale considers green perceived value multidimensional second order construct comprising functional value social value conditional value emotional value dimensions attempt made highlights originality value present study scale used assess consumers perception towards green energy information would help formulating strategies encourage consumers voluntarily adopt green energy study also reveals financial aspects lead consumers decide adoption green energy consumers also driven emotional social considerations thus policy makers could formulate pro green energy programmes mass messages appeal consumers sense responsibility voluntarily adopt green energy without rely financial incentives researchers could examine considered dimensions scale respect constructs related consumer behaviour elsevier ltd rights reserved
determine impact insurance status income anaplastic astrocytoma data extracted national cancer data base chi square test kaplan meier method cox regression models employed spss armonk ibm corp data analyses patients diagnosed identified private insurance medicare medicaid uninsured uninsured likely black hispanic versus white asian lower median income less educated receive adjuvant chemoradiation income lower income likely black hispanic versus white asian uninsured reside rural area less educated receive adjuvant chemoradiation private insurance significantly higher overall survival uninsured medicaid medicare significantly higher lower income multivariate analysis age insurance status income adjuvant therapy independent prognostic factors uninsured income independent prognostic factors worse investigations warranted help determine ways ensure adequate medical care may sociallydisadvantaged outcome maximized patients regardless socioeconomic status
purpose review publication updates earlier review ever increasing knowledge genetic polymorphism hla discusses clinical relevance recent findings january known alleles hla nucleotide sequence level translated protein level known subtypes based one amino acid sequence differences subtypes exhibit differential association ankylosing spondylitis may even level hierarchy regard hand hla protective effect hcv effect also influenced subtypes hla may important implications designing anti viral vaccines global population also developing individualized treatments vaccines summary disease association disease protective roles hla suggest common ground promoting pronounced immune inflammatory response effective clearance pathogens might hand lead autoimmunity tissue injury circumstances
study examines role top managers values leadership advancing environmental sustainability also investigates effects stakeholder engagement restaurants environmental sustainability assesses impact related practices restaurant performance web based survey administered collect data top level restaurant managers united states sample selected panels recruited research company specializing panel surveys invitation emails sent managers responses returned retained final analysis response rate structural equation modeling used testing hypothetical relationships among key constructs proposed research model environmental values leadership stakeholder engagement environmental sustainability restaurant performance findings confirmed significant role top management values leadership advancing environmental commitment results also demonstrated strong impact stakeholder engagement restaurants commitment environmental sustainability finally indicated positive influence restaurants environmental sustainability performance financial nonfinancial performance study presents theoretical framework integrating theories models extant literature contributes enhanced understanding restaurants environmental sustainability findings suggest several practical implications managers restaurant industry elsevier ltd rights reserved
ability parabens promote appearance multiple cancer hallmarks breast epithelium cells provides grounds regulatory review implication presence parabens human breast tissue well documented telomere dysfunction plays significant role initiation genomic instability carcinogenesis human breast cancer present study evaluated genotoxic effect ethyl hydroxybenzoate ethyl paraben without metabolic activation studies following oecd guidelines observed significant increase genotoxic damage using mouse lymphoma assay vitro micronucleus tests cell line presence short exposure high frequency observed cells short exposure presence long exposure without found significant increases frequency induced chromosomal aberrations lymphocytes one donor ethyl paraben exposure presence short exposure cytogenetic characterization paraben treated cells demonstrated telomere shortening associated telomere loss telomere deletions cells lymphocytes paraben sensitive donor control cohort human lymphocytes telomere length telomere aberrations age dependent showed high inter individual variation study first link telomere shortening genotoxic effect ethyl paraben presence raises possibility telomere shortening may proxy underlying inter individual sensitivity ethyl paraben copyright john wiley sons ltd
microwave powered cold plasma treatment cpt investigated nonthermal intervention technology improving microbiological safety cherry tomatoes solanum lycopersicum var cerasiforme salmonella approximately log cfu tomato cherry tomatoes subjected cpt using helium oxygen gas mixture min plasma generation power central composite method applied investigate interactions treatment conditions salmonella reduction rate weight loss temperature tomatoes cpts using gas mixture min resulted greatest reduction salmonella numbers log cfu tomato respectively temperature increases degrees respectively cpt min determined optimal conditions salmonella inactivation study appreciably influence surface morphology cherry tomatoes optimal cpt effectively inhibit growth salmonella tomatoes degrees treatment prevented salmonella growth storage degrees without affecting tomato respiration rate results demonstrate potential cpt postharvest technology improve microbiological safety cherry tomatoes salmonella without affecting biological properties elsevier rights reserved
background estimated approximately one third pregnancies canada unintended meaning either mistimed woman wanted pregnant different point time undesired woman want pregnant study aimed assess impact socioeconomic variables method contraception decision either terminate continue unintended pregnancy methods data obtained two contemporaneous studies calgary canada cross sectional study involving women seeking abortion services longitudinal cohort study involving women continuing pregnancies chi square tests logistic regression used examine association socioeconomic variables use contraception pregnancy intention results women seeking abortion women ongoing pregnancies reported unintended pregnancy women unintended pregnancies significantly younger less educated lower household income less likely stable relationship less likely speak english home reported using form birth control despite desire get pregnant among women unintended pregnancies significant demographic predictor using form contraception low educational attainment conclusions low educational attainment associated using form contraception among women unintended pregnancies however unintended pregnancy occurs across socio demographic groups care providers encouraged open discussion regarding fertility goals contraception patients refer appropriate resource materials
objectives common practice individualize smoking cessation pharmacotherapy based clinical judgment patient response however little documented use outcomes smoking cessation pharmacotherapy real world settings study examines factors associated using smoking cessation pharmacotherapy related outcomes among smokers psychiatric substance use disorders completed intensive tobacco treatment program within mental health addiction services settings vancouver canada methods retrospective analysis used examine combined program participation data two tobacco treatment programs tobacco dependence clinic butt group september july changes smoking cessation pharmacotherapy initial final treatment seven day point prevalence smoking abstinence verified expired carbon monoxide assessed end treatment results treatment participants remained initial pharmacotherapy plan received adjunctive treatment treatment plans switched whose pharmacotherapy switched higher cigarette consumption nicotine dependence baseline less likely psychiatric disorder history comparing pharmacotherapy groups individuals switched medications less likely achieve abstinence end treatment compared whose medication treatment plans remained received adjunctive treatment unchanged adjunctive switched chi multivariate regression analysis switching pharmacotherapy associated lower smoking cessation significantly mediated effectiveness pharmacotherapy differences medication switching rates clinical level limitations assessing impact mental illness substance use disorder variables conclusions least individuals may smoking cessation pharmacotherapy plan changed treatment switching pharmacotherapy may indicate subgroup smokers characterized greater challenges smoking cessation findings may enhance algorithms using smoking cessation pharmacotherapy clinical practice provide directions future research treating tobacco use disorder among individuals mental health substance use disorders
brain data processing embracing big data era driven rapid advances neuroscience well experimental techniques recording neuronal activities processing massive brain data become constant neuroscience research practice vital revealing hidden information better understand brain functions malfunctions brain data routinely non linear non stationary nature existing algorithms approaches neural data processing generally complicated order characterize non linearity non stationarity brain big data processing pressing needs appropriate computing technologies address three grand challenges efficiency scalability reliability recent advances computing technologies making non linear methods viable sophisticated applications massive brain data processing general purpose computing graphics processing unit gpgpu technology fosters ideal environment purpose benefits tremendous computing power modern graphics processing units massively parallel architecture frequently order magnitude larger modern multi core cpus article first recaps significant speed ups existing algorithms aided gpgpu neuroimaging processing electroencephalogram eeg functional magnetic resonance imaging fmri magnetoencephalography meg etc article demonstrates series successful approaches processing eeg data various dimensions scales massively parallel manner decomposition massively parallel ensemble local mean decomposition elmd algorithm aided gpgpu decompose eeg series forms basis time frequency transformation real time without sacrificing precision processing synchronization measurement parallelized nonlinear interdependence nli method global synchronization measurement multivariate eeg speed times successful localization epileptic focus dimensionality reduction large scale parallel factor analysis excels run time performance scales far better hundreds times conventional approach supports fast factorization eeg channels practices massively parallel computing technology manifests great potentials addressing grand challenges brain big data processing copyright john wiley sons ltd
background sports medicine matured focused discipline within primary care number primary care sports medicine physicians growing annually practices physicians range part time sports medicine part broader practice primary specialty functioning full time team physician university college managed care organizations increasingly incorporating primary care sports medicine providers organizations optimal role providers managed care system described methods descriptive analysis made patient contacts referral based free standing primary care sports medicine clinic associated large managed care system study describes patient information including demographic data referral source primary diagnosis specialized diagnostic testing subsequent specialty consultation results total patient contacts analyzed new patients referred full range physicians primary care family practice internal medicine pediatrics emergency physicians specialists family practice clinic providers physicians physician assistants nurse practitioners accounting largest percentage new referrals majority patient visits orthopedic injuries frequently involved injury sites knee shoulder back ankle common types injury tendinitis chronic anterior knee pain ligament sprains specialized testing requested patients majority patients treated belvoir sports medicine clinic primary care sports medicine physicians without specialty referral conclusions primary care sports medicine physicians offer intermediate level care patients maintaining practice primary care specialty dual practice ideal managed care setting study demonstrates complementary nature primary care sports medicine orthopedics primary care sports medicine physician reducing demand orthopedists nonsurgical treatment study also demonstrates need revision orthopedic curriculum primary care physicians
introduction hormonal contraceptives used million people worldwide recently emerging interest studying potential impact oral contraceptives ocs certain neurological conditions suspected time hormonal birth control increases seizure activity women epilepsy little supportive data areas covered literature pubmed online sources analyzed respect hormonal contraception epilepsy seizures new evidence indicates ocs cause increase seizures women epilepsy epilepsy birth control registry surveyed women epilepsy found using hormonal contraceptives self reported times seizures use contraceptives preclinical study confirmed outcomes wherein epileptic animals given ethinyl estradiol primary component ocs frequent seizures likely resistant expert commentary pills may increase seizures women epilepsy refractory seizures likely cause neuronal damage brain thus women child bearing age epilepsy consider using non hormonal forms birth control avoid risks pills additional research mechanisms prospective clinical investigation needed
biorefinery context thermochemical processes attracted significant attention recent years processes generally consist three main steps pretreatment thermochemical treatment post treatment developing processes drying feeding biomass feedstock remain significant costly challenge moisture content biomass feedstock must decreased economic level pretreatment step otherwise detrimental effect process efficiency quality products work addresses drying biomass feedstock using novel practical technology called biodrying green technology offers opportunity biomass drying without using external heat source fossil fuels since drying energy generated exothermic microbial activity biomass enhances drying rate paper focuses technoeconomic assessment continuous biodrying technology integrated gasification based biorefinery investigates conditions make novel technology viable conjunction gasification process fixed capital investment operating cost different biodrying scenarios estimated respectively potential benefits sludge landfilling cost energy savings carbon credit integration continuous biodrying system gasification process implemented pulp paper mill calculated ultimately economic performances scenarios assessed furthermore viable biodrying conditions specified day residence time major viability risk found bound moisture biomass
twitter grown significantly past several years provides new vector data collection offering individual users companies valuable insights presents technical challenge collect analyze data efficient manner traditional relational databases able provide acceptable response times new problem presents focus started shifting newer technologies nosql databases paper try answer question follows want store access millions tweets data analysis database systems choose selected four popular sql nosql database systems tested different twitter dataset varying one million fifty million tweets workload test involves running core set data operation commands experiment results promising provide guideline choosing efficient database systems based different user requirements
developments innovations technology new materials methods enabled architects engineers plan construct large scale facilities however developments may also result serious problems include budget overruns completion delays distress part facility owner avoid problems many types delivery systems contain force account system design bid build system design build system construction management risk cmar system employed world construction market every system could complete one inherit limit midst systems cmar system finally changed delivery one among systems many merits construct manage facilities korea cmar system introduced conceptually applied public construction market yet therefore promote application cmar system korean public construction market review construction delivery systems conducted focus cmar systems descriptively analyzed suggested specialized construction management services streamlined bidding contracting regulations reasonable allotment contract risk essential tools successful construction projects
article deals experimental verification stress distribution inside tensile test specimen using recently developed gripping system upper yield strength materials low carbon steels could extremely sensitive elastic stress distribution inside test piece evolution stress distribution inside sample elastic loading strong correlation initial alignment gripping methodology test piece gripping system influences strongly value upper yield strength therefore application suitable gripping system essential exact value upper yield strength necessary know current work special test piece equipped strain gauges used measure stress distribution elastic loading tensile test piece results show new gripping system could provide almost pure uniaxial conditions moreover uniaxial even non uniaxial loading adjusted repeated small deviation
background maternal psychiatric symptoms pregnancy might affect developing immune system subsequent risk childhood atopic diseases objective aim examine associations maternal psychiatric symptoms pregnancy allergic sensitization allergy eczema children age years methods study among children performed population based prospective cohort foetal life onwards assessed maternal paternal psychiatric symptoms overall depressive anxiety pregnancy months delivery maternal psychiatric symptoms months delivery using brief symptom inventory inhalant food allergic sensitization measured skin prick tests physician diagnosed inhalant food allergy eczema questionnaires birth age years used multivariate logistic regression multinomial logistic regression generalized estimating equation models appropriate results observed association maternal psychiatric symptoms pregnancy allergic sensitization maternal overall psychiatric depressive anxiety symptoms pregnancy associated increased risk inhalant allergy adjusted odds ratio confidence interval respectively per unit increase maternal overall psychiatric anxiety symptoms pregnancy associated increased risk eczema respectively per unit increase effect estimates materially change maternal psychiatric symptoms delivery paternal psychiatric symptoms pregnancy delivery taken account conclusions clinical relevance maternal psychiatric symptoms pregnancy associated increased risks childhood inhalant allergy eczema independent maternal psychiatric symptoms delivery paternal psychiatric symptoms
little focus nonverbal communication social media advertising campaigns propose specific patterns facial expressions predict popularity youtube videos among users social media test proposition used neuromarketing tool facereader code facial videos professional speakers participated youtube social media campaigns large commercial banks analyzed video frames speakers basic facial expressions found less incidence affiliative facial emotions happiness sadness incidence nonemotional expressions surprise explained additional variance video popularity number youtube views months july comparison october baseline predictor showed disaffiliative facial emotions speakers anger fear disgust contribute indicator future performance social media content hope findings open new lines research corporate communication incorporating neuromarketing nonverbal communication understand content effective presented
green building practices created opportunity forest products industry become leader creation innovative building products derived renewable materials industries sandwich composites proven efficient structures meeting structural demands traditional panel products consuming less material prototype molded core sandwich panel made span rated oriented strand board osb facings bidirectional molded wood strand core produced critical mechanical properties evaluated determine feasibility product use building applications goals study generate details structural performance product validate design provide suggestions future product development results indicate molded core panel performs particularly well flexure connection properties largest scope improvement sufficient performance observed validate design warranting production testing panels sized end use future product development explore different connection systems perform detailed engineering analyses mechanical properties necessary complete structural design characterize physical properties panel
dense buildings major factor affecting urban flood routing currently study urban dam break flood routing primarily focuses simplified terrain model shallow water equations ignore effects dense urban buildings furthermore complex interactions dam break wave wall surfaces buildings reflected results tackle problems three dimensional flood routing high precision digital model urban area studied paper firstly vector data various land types extracted remote sensing image nurbs algorithm based tin algorithm introduced construct three dimensional terrain model coupled vector data terrain model three dimensional digital model urban area established next three dimensional epsilon turbulence model proposed flood routing simulation polyhedral grid second order accuracy discrete format used divide digital model urban area governing equations solved using piso algorithm finally superiority mathematical model computational efficiency polyhedral mesh model validated according urban flood routing experiments testa soares frazao urban reservoir located city china modelled show dam break flood urban area exhibits significant three dimensional characteristics moreover due surrounding buildings flood exhibits complex three dimensional turbulence phenomena including collision reflection vortices
complex systems social networks composed interactive employees interconnected collaborative dynamic ties shared goals perspectives needs complex systems largely based complex system theory complex system theory focuses mainly finding developing strategies behaviours foster continuous learning resonating new conditions creativity organizations dynamic collaborative management mentality complex systems surely need leaders manage complexity complexity leadership could defined adaptive mechanisms developed complex organizations new conditions required information age rather technical problems entailed industrial age complexity leadership joint resultant product following three types leadership administrative leadership based strict control significant bureaucratic hierarchy adaptive leadership fundamentally based creative problem solving resonating new conditions learning action centered leadership involves immediate decision making mechanisms employed crises dynamic productivity study focuses complexity leadership within context complexity leadership theory
paper authors present method facilitates computationally efficient parameter estimation dynamical systems continuously growing set measurement data shown proposed method utilises sequential monte carlo samplers guaranteed fully parallelisable contrast markov chain monte carlo methods applied wide variety scenarios within structural dynamics ability allow convergence one parameter estimates data analysed sets apart sequential methods particle filter elsevier ltd rights reserved
objectives study association clinical ultrasound variables patients pga physicians ega global assessment disease activity psoriatic arthritis psa correlation parameters discordance pga ega well pga ega changes months also investigated methods prospective study consecutive psa patients visits scheduled months apart patients underwent following assessments tender tjc swollen joint count sjc pasi dactylitis leeds enthesitis index pga patients level pain pain vas ega haq also recorded grey scale power doppler ultrasound performed joints evaluating synovia tendons entheses regression analyses performed assess association variables pga ega two new variables pga minus ega pgachange egachange developed explore discrepancy pga ega consistency pga ega changes time respectively results parameters explaining pga ega variability pain vas sjc respectively correlation ega joint counts stronger patients high low levels ultrasound verified inflammation pga minus ega mainly explained pain sjc pain important predictor pga change whereas tjc haq closely associated ega changes pgachange egachange linked pain sjc ultrasound scores linked either variables conclusions pain vas joint counts important clinical parameters explaining patients physicians perception disease activity whereas correlation active inflammation verified sonography factors limited elsevier inc rights reserved
around million people worldwide suffer rare diseases may genetic infectious autoimmune basis several include inflammatory component launching effective treatments challenging low disease prevalence limited scientific insights disease mechanisms key trigger inflammatory processes complement associated variety diseases become attractive therapeutic target conditions involving inflammation view clinical experience acquired drugs licensed treatment rare diseases hereditary angioedema paroxysmal nocturnal hemoglobinuria growing evidence supports safety efficacy complement therapeutics restoring immune balance preventing aggravation clinical outcomes review provides overview candidates currently pharmaceutical pipeline potential treat orphan diseases discusses molecular mechanisms triggered complement involved disease pathogenesis elsevier inc rights reserved
background improved anticoagulation control warfarin reduces adverse events represents target quality improvement previous study described effort improve anticoagulation control across health system objective describe results effort improve anticoagulation control new england region veterans health administration methods intervention encompassed sites managing warfarin patients new england veterans integrated service network visn provided sites system measure processes care along targeted audit feedback focused processes care associated site level anticoagulation control including prompt follow range international normalized ratio inr values minimizing loss follow use guideline concordant inr target ranges used difference differences model examine changes anticoagulation control measured percentage time therapeutic range ttr well process measures compared visn sites sites located outside visn results visn sites improved ttr main indicator quality whereas sites outside visn improved improvement ttr correlated strongly extent improvement processof care measures varied widely across visn sites conclusions regional quality improvement initiative using performance measurement audit feedback improved ttr control sites clinically important difference improving relevant processes care improve outcomes patients receiving warfarin
current rate success launching satellites advances onboard ground image processing led dramatic increase scale remote sensing image data resulted considerable research provide best quality experience end users however subjective image quality assessment iqa time consuming cumbersome expensive implemented automatically using computers thus subjective iqa may suitable application requirements paper design construct usability based subjective remote sensing iqa database corresponding reference iqa method also proposed new iqa method uses scale invariant feature transforms form dictionary support vector machine obtain iqa model experimental results show new subjective iqa database highly suited task quality predictions new iqa method correlate well human subjective scores new database
background safety hpv vaccines still question due reports autoimmune diseases ads following hpv immunization objectives assess risk ads associated hpv vaccination female adolescents young adults france methods systematic prospective case referent study conducted assess risks associated real life use hpv vaccines cases female years old incident ads central demyelination multiple sclerosis connective tissue disease ctd guillain barre syndrome gbs type diabetes autoimmune thyroiditis idiopathic thrombocytopenic purpura itp cases consecutively prospectively identified specialized centers across france individually matched age place residence referents recruited general practice risk computed using multivariate conditional logistic regression models adjusted family history ads living france north south medications vaccinations results total definite cases matched referents ads combined negatively associated hpv vaccination adjusted odds ratio confidence interval similar results obtained last two reaching statistical significance association found itp gbs sensitivity analyses combining definite possible cases secondary time window showed similar results conclusion exposure hpv vaccines associated increased risk ads within time period studied results robust case definitions time windows exposure continued active surveillance needed confirm finding individual ads authors published elsevier ltd
study investigated essential criteria late onset hypogonadism loh syndrome based presence symptoms associated low testosterone levels han chinese men blood tests total testosterone sex hormone binding globulin shbg performed aging male symptoms ams questionnaire conducted randomly selected cohort composed chinese men aged years nine urban communities three sexual symptoms decreased ability frequency sexual activity decreased number morning erections decreased libido confirmed related total free testosterone levels thresholds approximately nmol decreased ability frequency perform sex nmol decreased frequency morning erections nmol decreased sexual desire calculated free testosterone cft thresholds three sexual symptoms pmol respectively nmol cft pmol associated increase aforementioned three sexual symptoms prevalence loh criteria including three sexual symptoms levels nmol cft levels pmol results may improve diagnostic accuracy loh older men
frontotemporal dementia ftd second common dementia years age haploinsufficiency progranulin grn gene accounts cases familial ftd grn mutation carriers increased risk autoimmune disorders accompanied elevated levels tissue necrosis factor tnf alpha examined behavioral alterations related obsessive compulsive disorder ocd role tnf alpha related signaling pathways ftd patients grn mutations mice lacking progranulin pgrn found patients mice grn mutations displayed ocd self grooming ocd like behavior mice respectively furthermore medium spiny neurons nucleus accumbens area implicated development ocd display hyperexcitability pgrn knockout mice reducing levels tnf alpha pgrn knockout mice abolished excessive self grooming associated hyperexcitability medium spiny neurons nucleus accumbens brain pgrn highly expressed microglia major source tnf alpha therefore deleted pgrn specifically microglia found sufficient induce excessive grooming importantly excessive grooming mice prevented inactivating nuclear factor kappa microglia myeloid cells findings suggest pgrn deficiency leads excessive kappa activation microglia elevated tnf alpha signaling turn lead hyperexcitability medium spiny neurons ocd like behavior
silver doped pbmg pbtio relaxor ferroelectrics prepared solid state reaction electrocaloric behaviors room temperature characterized content silver around electro caloric effect adiabatic temperature changes highest results show heat exchanges related electro caloric energy conversion adiabatic temperature changes increase increasing polarization ferroelectric ceramics ceramics found promising energy conversion materials engineering applications
periphery homeostasis immune system depends equilibrium expanding contracting lymphocytes immune response important mechanism lymphocyte contraction clonal depletion activated cells cytokine withdrawal induced death cwid tcr restimulation induced cell death ricd deficiencies signaling components cwid ricd leads autoimmunune lymphoproliferative disorders mouse human important feature cwid ricd clonal specificity lends great appeal strategy targeted tolerance induction treatment autoimmune diseases allergic disorders graft rejection depleting undesired disease causing cells keeping overall host immunity intact
background assessment pituitary mass objective visual field testing represents valuable means evaluating mass effect thus deciding whether surgical management warranted case presentation vignette describe year old lady presented three week history frontal headache blurriness left side vision due grade iii anaplastic haemangiopericytoma compressing optic chiasm report timely investigations including ipad based visual field test melbourne rapid field mrf conducted bedside aided swift appropriate management patient conclusions envisage test role assessing bed bound patients hospital access formal visual field testing difficult indeed rapid testing visual fields bedside screen postoperative complications haematoma
nanocomposite electrical generator composed zinc oxide nanowires zno nws modeled using continuum mechanics maxwell equations axial loading considered optimum aspect ratio zno nws getting maximum electric potential calculated bonding zno nws polymer matrix considered perfect linear piezoelectric behavior assumed shown electric potential maximum minimum values opposite signs extreme ends along nanowire length maximum generated electric potential varies aspect ratio one aspect ratio thirty optimum aspect ratio zno defined difference maximum generated electric potential difference becomes less results aspect ratio results major step toward producing zno nws nanocomposite electrical generators maximum performance
objectives human cell lymphotropic virus type htlv infection associated neurological abnormalities htlv associated myelopathy tropical spastic paraparesis ham tsp peripheral neuropathy hepatitis virus hcv infection leading cause chronic liver disease worldwide causes approximately patients interplay potentially neuropathogenic viruses individual still poorly understood clinical laboratory outcomes infected patients evaluated compared controls methods prevalence rates neurological laboratory abnormalities evaluated hcv htlv infected patients subjects single hcv htlv infection results higher frequency isolated present hcv infected patients associated cryoglobulinemia difference found frequency ham tsp infected subjects compared singly infected subjects hepatic involvement present hcv infected subjects shown increased levels serum alanine aminotransferase aspartate aminotransferase gamma glutamyl transferase bilirubin addition thrombocytopenia hand hcv htlv infected individuals presented better prognosis hepatic involvement compared singly hcv infected subjects conclusions data suggest hcv htlv infection mutualistically alter outcome regard neurological manifestations nonetheless changes immunological environment induced htlv infection could lead reduction hepatic damage even without significant hcv clearance published elsevier ltd behalf international society infectious diseases
background hypothyroidism referred rare possible cause hyponatremia however poor evidence supporting association since hyponatremia hypothyroidism common conditions occurrence causal methods address potential relationship retrospective analysis data division endocrinology medical university vienna april february performed total hypothyroid patients years age female thyrotropin available blood tests free thyroxine sodium within maximal seven days included screened hyponatremia patients records searched concomitant disease medication concentration mmol results hyponatremia present patients analysis medical history revealed potential alternative causes hyponatremia patients side effects medication concomitant underlying disease endocrine disorders distribution differ patients suffering clinical subclinical hypothyroidism case clinically relevant hyponatremia mmol present patients could attributed hypothyroidism weak statistically significant trend toward positive association thyroid function serum levels thyrotropin free thyroxine conclusion results suggest hypothyroid patients moderate severe hyponatremia often potential explanations low serum concentrations routine care
past research shown abusive supervision linked negative outcomes employees chiefly employees counterproductive work behaviors directed organizations study examined relationships two types ineffective supervision abusive supervision authoritarian leadership style employees distal negative outcomes exhaustion physical symptoms job dissatisfaction intention quit poor job performance sample nurses supervisors addition study examined emotional reactions anxiety depression mediated negative relationships ineffective leadership employees distal outcomes results suggested types ineffective leadership related similar negative employee outcomes anxiety depression mediated relationships conclusions study contribute ineffective leadership literature connecting previous findings abusive supervision authoritarian leadership style organizations utilize results raise awareness among supervisors implications behaviors workplace employees welfare organizational effectiveness
objective borderline personality disorder bpd highly prevalent diagnosis mental health care includes heterogeneous constellation symptoms field personality disorder research moves emphasize dimensional traits operationalization important determine alternative dsm section iii personality trait dimensions differentiates features bpd patients versus comparison groups date study attempted validation method current study examined utility dsm trait dimensions differentiating patients categorical dsm diagnosis bpd systematically matched samples patients healthy controls investigated using one way anova multinomial logistic regression analyses results results indicated emotional lability risk taking suspiciousness uniquely differentiated bpd patients patients whereas emotional lability depressivity suspiciousness uniquely differentiated bpd patients healthy controls conclusion emotional lability particular key bpd feature proposed section iii model whereas suspiciousness also augments essential bpd features provided findings replicated cross culturally forthcoming research parsimonious traits operationalization bpd features warranted elsevier masson sas rights reserved
normal digestive tract microbiota plays essential role maintaining homeostasis normal development digestive tract metabolism immunity angiogenesis treatment antibiotics especially children often associated significant changes intestinal microbiota lead intestinal disbioses probiotic bacteria used century promote digestive health objective study investigate interrelations probiotic bifidobacterium strains isolated infants faeces studying influence expression antibiotic resistance enteropathogenic strains recently isolated digestive tract infections study demonstrates probiotics associated antibiotics increase enteropapathogens susceptibility aminoglycosides beta lactams amoxicillin plus clavulanic acid quinolones carbapenems
mix fantasy history spirituality political engagement elvira giallanella film umanita sort carrollian looking glass reality resembles upside immediate aftermath wwi giallanella film revision vittorio emanuele bravetta children story children story reflects critiques gender roles temporarily fissured war feminist position transpires juxtaposition pre war male authored text postwar female directed film revised men invaluable historical source umanita offers insight woman feminist perspective great war aftermath also sheds light moral political philosophical atmosphere destabilization time coming full circle umanita suffered revisions established postwar patriarchy end cinema reclaimed male territory leaving film lost amongst debris umanita resurfacing allows reflect process history making omitted included importantly whose voices validated enough heard along way instance one amongst several serve example history indeed continuous process made visions never singular univocal one
adaptive modulation problem tackled paper completely new perspective using system dynamics analysis establishing state space representation adaptation system feedback controller designed adjust modulation parameter meet adaptation criteria compared existing adaptation algorithms proposed approach yields optimal resource allocation without pre computation signal noise ratio snr region boundaries still maintaining desirable quality service
article chip self calibrated bit digital analog converter dac based digitally compensated input offset operational amplifier opamp presented improve overall dac performance digital offset cancellation method used compensate deviations input offset voltage opamp caused process variations whole dac well offset compensation circuitry designed standard cmos process achieved results show self calibration process improvement value dac offset error achieved
perfectionism known highly prevalent obsessive compulsive disorder ocd review seeks explore perfectionism ocd related disorders particularly relation treatment order inform treating clinicians also evaluate potential role perfectionism maintenance ocd evidence supports perfectionism transdiagnostic process central psychopathology ocd mental illnesses treatment outcomes ocd diminished presence perfectionism thought due inherent treatment interfering features perfectionism successful ocd treatment shown decrease perfectionistic thinking though data mixed whether reducing perfectionism mediates subsequent reductions ocd symptoms short term cognitive behavioral protocols perfectionism reviewed recommendations made treatment perfectionism context ocd related disorders
microwave assisted extraction moringa oleifera lam leaf polysaccharides investigated using response surface methodology following conditions found generate experimental yield closely agreed predicted value time min microwave power temperature degrees liquid solid ratio mlps treated graded precipitation ethanol solution respective average rholecular weight polysaccharide fractions namely mlp kda mlp kda mlp kda obtained three fractions composed xylose mannose glucose galactose arabinose differing molar ratios similar fourier transform infrared spectroscopy surface morphology differed determined scanning electron microscdpy congo red assay indicated three fractions helical polysaccharides three polysaccharide fractions exhibited different rheological properties mlp exhibited pseudoplastic flow behaviors mlp displayed near newtonian flow behaviors entire accessible frequency range addition mlp stronger inhibitory effects amylase glucosidase mlp mlp results suggest mlp potential treatment diabetes elsevier rights reserved
heavy lifting exceptional transport equipment developed amazing way last two decades years ago transporting lifting elements weights sizes capable transport lift nowadays inconceivable big cranes used lift hundreds tons projects thousand tons important working radius alternative heavy lift systems gantries jacks etc used special jobs regarding transportation self propelled modular transporters spmt developing increasing number ton platforms moved wheels shipping also adapting fast scenario higher capacity geared vessels type multimodal ships capacity increase used civil industrial construction occasionally even building construction developing prefabrication modularization since opens possibility handle bigger heavier pieces advantages construction important better safety work achieved without working heights better quality working controlled environment prefabrication yards factories etc improving schedules working several parts simultaneously price reductions optimizing construction methods global sequence locations published elsevier ltd
paper class large deployable mechanisms constructed plane symmetric bricard linkages presented plane symmetric bricard linkage closed loop overconstrained spatial mechanism composed six hinge jointed bars one plane symmetry deployment process kinematic analysis linkage presented perspectives geometric conditions closure equations degree freedom results illustrate linkage one degree freedom deployed folded configuration one rectangle plane therefore plane symmetric bricard linkage used basic deployable unit construct larger deployable mechanisms four plane symmetric bricard linkages assembled quadrangular module sharing vertical bars adjacent units module multiloop deployable mechanism one degree freedom singularity analysis module developed two methods avoid singularity presented large deployable mast deployable plane truss deployable ring built several plane symmetric bricard linkages deployment properties large deployable mechanisms analyzed computer aided design models typical examples built illustrate feasibility validate analysis design methods
light current situation water resources egypt deficit resources rainwater harvesting assessment potentialities became necessary present study attempt made define decision based scientific approach identifying appropriate sites rainwater harvesting approach based gis data layers include dem landforms geologic setting watershed area rainfall amounts drainage lines morphometric parameters flow accumulation flow direction slope surface runoff also includes verification site suitability field investigations daba area chosen lack water agriculture drinking purposes addition area special interest planned nuclear power plant obtained results reveal study area contains eight basins slightly intensive drainage network morphometric analyses studied basins reveal opportunities surface runoff three showing high hazard degrees basins actual runoff ranges annually resulted average rainfall therefore management rainwater harvesting protections flash floods recommended many rainwater harvesting structures example concert dams alternative earth dikes surface water reservoirs cisterns established
chip gene expression analysis compartmentalized droplets developed detection cancer cells single cell level chip consists keyhole shaped reaction chamber hydrophobic modification employing magnetic bead droplet handling system gate bead separation using three kinds water based droplets oil droplet sample cells lysis buffer magnetic beads pcr buffer parallel magnetic manipulation fusion droplets performed using magnet handling device containing small external magnet patterns array actuation magnet offers simple system droplet manipulation allows separation fusion droplets containing magnetic beads reverse transcription amplification thermal cycling fluorescence obtained detection overexpressing genes clinical detection gastric cancer cells peritoneal washing overexpressing gastric cancer cells spiked within normal cells detected gene expression analysis droplets containing average cells developed droplet based cancer detection system manipulated external magnetic force without pumps valves offers simple flexible set transcriptional detection cancer cells greatly advantageous less invasive clinical diagnosis prognostic prediction
shock tube rapid compression machine rcm used measure new ignition delay times methanol oxidation wide range pressures atm equivalence ratios measurements include dilute fuel air conditions methanol temperature range new data compared previously published studies provides insight internal combustion engine relevant conditions previously studied pressures atm addition ignition delay times species concentrations also measured using jet stirred reactor jsr experiments methanol concentrations ppm used equivalence ratios pressures atm temperature range residence times varying newly measured experimental data used develop new detailed chemical kinetic model mech model also validated using available literature data new model capable predicting validation data reasonable accuracy discrepancy predicting formaldehyde jsr data results robustly validated accurate new detailed chemical kinetic model combustion institute published elsevier inc rights reserved
recursive smoothing filter employing bank fading memory polynomial sub filters presented variance estimates used mix outputs sub filters imparting variable gain phase characteristics permit automatically adapt signal parameter changes proposed adaptive technique involve estimation plant parameters therefore may used open loop closed loop configurations open loop estimation problems variable gain bandwidth allows reduce impact random errors caused sensor noise impact bias errors caused model mismatch maneuvers feedback control problems variable phase delay allows act lag filter improved steady state response greater noise attenuation act lead filter proportionalderivative controller improved transient response increased closed loop damping input discontinuities copyright john wiley sons ltd
study aims analyze performance conventional distribution network covered cables called compact ones bare cables still used old distribution lines since cheaper covered ones however nowadays almost electricity companies started study feasibility installation compact distribution lines benefits regarding maintenance reduction outages therefore research aims analyze technical losses compact distribution networks compared conventional ones purpose electrical conductors modelled using atp software results taken matlab software perform three phase power flow calculation newton raphson method three different topologies distribution networks tested real system composed bare covered cables conventional system bare cables compact one covered cables simulation results demonstrated efficiency second topology better others
paper introduce new concept called generalized ring signcryption grsc achieve ring signature ring signcryption functions one key pair one algorithm useful system large number users limited storage space whose function requirements may changed later give formal definition security model grsc propose concrete scheme based bilinear pairings random oracle model scheme confidentiality proved gbdh assumption unforgeability proved gdh assumption scheme also allows unconditional anonymity compared identity based ring signcryption schemes use bilinear pairings well scheme highly efficient one
two common simple stormwater control measures swales filter strips however overly simplistic one size fits design approach typically used practices provide flexibility design coupled hydraulics particle settling model created predict swale filter strip total suspended solids tss reduction function catchment area longitudinal slope side slope cross section type triangular swale trapezoidal swale filter strip length hydraulics hydrology models based manning equation rational method respectively underlying requirement water quality design storm exceed height grass particle settling model underpinned aberdeen equation model predicts triangular swales produce least filter strips tss removal increased hydraulic retention time trapezoidal swales average greater tss removal triangular swales similar design characteristics grass filter stormwater controls performed better decreasing slope increasing length smaller catchment area shallower side slopes filter strips registered majority tss reduction within first meter width insensitive increases longitudinal slope water quality design storm abating modeling approach could coupled modeling infrequent return interval storms obtain dual benefits sediment reduction conveyance water quality model may provide regulatory agencies tool provide variable tss credit swales filter strips function design american society civil engineers
normal meniscus undergoes typical developmental changes childhood reaching mature adult appearance approximately years age addition recognizing normal meniscal appearances children identifying abnormalities tears different types discoid meniscus meniscal cysts well surgical implications abnormalities vital pediatric imaging reported incidence meniscal tears adolescents young adults increased increased sports participation widespread use mri review discusses normal appearance pediatric meniscus meniscal abnormalities associated injuries prognostic indicators repair
axial spondyloarthritis axspa encompasses ankylosing spondylitis complex genetic disease aberrant bone formation key feature pathogenesis lead ankylosis spine objective determine whether genes whose variants confer susceptibility expressed bone progenitors like mesenchymal stem cells mscs since mscs bone marrow difficult obtain first examined whether mscs derived induced pluripotent stem cells ipscs dermal fibroblasts two axspa patients one healthy control reprogrammed ipscs using sendai virus vector encoding pluripotency genes pluripotency ipscs examined embryoid body formation testing stem cell specific gene protein expression using pcr immuno fluorescence ipscs differentiated mscs tgf inhibitor mscs characterized flow cytometry using lineage specific antibodies capacity develop chondrocytes adipocytes osteoblasts lineage specific medium rna seq applied determine genome wide gene expression patterns mscs ipscs blood show first time expression levels several susceptibility genes edil ano hapln antxr involved bone formation significantly elevated mscs fold compared blood ipscs demonstrate ipsc derived mscs differentiated osteoblasts chondrocytes adipocytes conclude mscs generated patient fibroblast derived ipsc lines useful tools studying functional genomics risk genes associated bone formation pathogenesis
objective study aims evaluate effectiveness safety gua sha therapy perimenopausal symptoms quality life serum female hormones participants perimenopausal syndrome methods prospective randomized controlled clinical trial conducted first affiliated hospital nanjing university chinese medicine china eighty women perimenopausal syndrome recruited randomized intervention group control group participants intervention group received minute gua sha treatment sessions week plus conventional treatment weeks whereas participants control group received conventional treatment alone primary outcome change perimenopausal symptoms quality life obtained modified kupperman index menopause specific quality life secondary outcome change serum female hormones including estrogen follicle stimulating hormone luteinizing hormone results seventy five participants completed study intervention group control group baseline levels demographic outcome measurements comparable two groups eight sessions intervention reduction total modified score however intervention group control group difference two groups also reductions hot flash sweating paresthesia insomnia nervousness melancholia fatigue headache greater intervention group control group reduction total menopause specific quality life score intervention group control group difference two groups scores vasomotor psychosocial physical domains intervention group significantly lower control group significant differences serum estrogen follicle stimulating hormone luteinizing hormone two groups conclusions results study suggest gua sha therapy effective safe relieving perimenopausal symptoms improving quality life participants perimenopausal syndrome therapy may serve promising effective nondrug treatment perimenopausal syndrome clinical work additional research needed better understand effectiveness examine mechanism treating perimenopausal syndrome
objective currently consensus safety sports participation patients intracranial arachnoid cyst authors goal define risk sports participation children imaging finding methods survey prospectively administered patients acs month period single institution cyst size location treatment sports participation injuries recorded eighty patients completed least subsequent survey following initial entry registry patients included prospective registry mean prospective follow interval months results total patients acs participated sports cumulative duration months seasons patients participated contact sports cumulative duration months seasons serious catastrophic neurological injuries two patients presented symptomatic subdural hygromas following minor sports injuries prospective cohort neurological injuries conclusions permanent catastrophic neurological injuries unusual patients participate athletic activities cases sports participation patients safe
objective use receiver operating characteristics analysis identify multilevel diagnostic likelihood ratios provide framework diagnosis attentiondeficit hyperactivity disorder adhd children years old adolescents years old outpatient setting method caregiver teacher youth reports achenbach system empirically based assessment aseba obtained children adolescents multiple imputation missing data reference standard diagnosis adhd based case history semistructured diagnostic interview masked aseba measurements results children caregiver reported attention problems area curve auc outperformed subscales caregiver teacher measures aucs older sample caregiver teacher reported attention problems caregiver auc teacher auc best identifying adhd inclusion caregiver teacher reports significantly comparisons increased prediction adhd diagnosis whereas youth self report conclusion caregiver reported attention problems useful teacher reports self report identifying adhd combining caregiver teacher reports improved identification multilevel likelihood ratios provided facilitate routine clinical use
aim study association country birth incidence gout different immigrant groups sweden study population included whole population sweden gout defined least one registered diagnosis national patient register association incidence gout country birth assessed cox regression hazard ratios hrs confidence intervals using swedish born individuals referents models conducted men women full model adjusted age place residence sweden educational level marital status neighbourhood socio economic status morbidities risk gout varied country origin highest estimates compared swedish born fully adjusted models among men iraq russia also high among men austria poland africa asian countries outside middle east among women africa hungary iraq austria also high among women poland risk gout lower among men greece spain nordic countries except finland latin america among women southern europe compared swedish counterparts increased risk gout among several immigrant groups likely explained high cardio metabolic risk factor pattern needing attention
one step aldol condensation methyl acetate formaldehyde trioxane preparing methyl acrylate stimulated researchers attention recent years herein new methodology one step synthesis methyl acrylate methyl acetate trioxane promoted generated trifluoromethanesulfonate ionic liquid via aldol condensation mild temperature developed kinetic thermodynamic studies new process also firstly investigated systematically experiments conducted batch reactor temperatures reaction times min min wherein side reactions could ignored proposed mechanism based kinetic model established simulated experimental data model showed good agreement experimental results within range acceptable deviation thereby pre exponential factor activation energy reaction step obtained moreover equilibrium constant enthalpy change reversible reaction also calculated van hoff formula elsevier rights reserved
objectives individual eating behavior risk factor obesity highly dependent internal external cues many studies also suggest food environment food outlets influences eating behavior study therefore examines momentary food environment time eating role cues simultaneously predicting everyday eating behavior adults overweight obesity method intensive longitudinal study using ecological momentary assessment ema days adults overweight obesity average body mass index total participant days data multiple daily assessments eating meals high low energy snacks randomly timed assessments cues momentary food environment assessed assessment types results random effects multinomial logistic regression shows internal affect external food availability social situation observing others eat cues associated increased likelihood eating momentary food environment predicted meals snacking top cues higher likelihood high energy snacks fast food restaurants close odds ratio confidence interval higher likelihood low energy snacks proximity supermarkets conclusions real time eating behavior terms main meals snacks associated internal external cues adults overweight obesity addition perceptions momentary food environment influence eating choices emphasizing importance integrated perspective eating behavior obesity prevention
digit ratios especially ratio potential proxy marker prenatal androgen exposure shows sexual dimorphism existing literature recent research show accumulating evidence ratio showing correlations various phenotypic traits humans ratio found correlate negatively testosterone positively oestrogen foetus interestingly constant since birth influenced adult hormone levels usually males lower ratios compared females prenatal androgen exposure therefore digit ratios reported associated numerical competencies spatial skills handedness cognitive abilities academic performance sperm counts personalities prevalence obesity migraine eating disorders depression myopia autism etc authors attempted write brief account digit ratios dimorphism observed various physiological psychological behavioural traits also authors discussed relevant molecular basics methods measurement digit ratios
recent advances power generation renewable resources necessitate conversion electricity chemicals fuels efficient manner electrocatalytic water splitting one powerful widespread technologies development highly efficient inexpensive flexible versatile water electrolysis devices desired review discusses significance impact electrolyte electrocatalytic performance depending circumstances water splitting reaction conducted required solution conditions identity molarity ions may significantly differ quantitative understanding electrolyte properties electrolysis performance effective facilitate development efficient electrocatalytic systems electrolyte directly participate reaction schemes kinetics affect electrode stability indirectly impact performance influencing concentration overpotential mass transport review aims guide fine tuning electrolyte properties electrolyte engineering photo electrochemical water splitting reactions
sentinel first family satellites designed provide data stream european environmental monitoring program known copernicus sentinel constellation specifically designed perform land advanced differential interferometric synthetic aperture radar dinsar analyses investigation earth surface displacements particular owning day revisit time innovative acquisition mode referred terrain observation progressive scans tops fundamental guaranteeing global spatial coverage sentinel constellation contributing creation framework exploitation big data earth observation applications paper present efficient automatic implementation parallel small baseline subset sbas dinsar algorithm specifically intended processing sentinel sar data algorithm able run distributed computing infrastructures effectively exploiting large number resources allows generation ground displacement time series aim paper show possible automatically continuously process short time frame large sequences sentinel data thus allowing perform advanced interferometric analyses unprecedented large scale addition proposed sentinel sbas algorithm also tested commercial public cloud computing platforms provided amazon web services presented sentinel sbas processing chain well suited build operational services easy rapid generation advanced interferometric products useful scientific purposes also risk management natural hazard monitoring authors published elsevier
objectives aim study assess prevalence anxiety depression ptsd related symptoms reported spouses close relatives adult burn survivors potential associations symptoms variables severity burn also explored method participants spouses close relatives hospitalized patients acute bums anxiety depression symptoms assessed hospital distress anxiety depression scale ptsd related symptoms modified ptsd symptom scale admission discharge burn unit results admission spouses close relatives burn patients reported anxiety depression ptsd related symptoms clinical range spouses higher scores close relatives symptom measures significant differences established anxiety symptoms significant effect found gender women reporting anxiety depression symptoms men results also showed main effect time anxiety depression ptsd related symptoms higher admission discharge variables associated index patient total body surface area burned length stay number ventilated days facial burns level care admission associated outcome measures conclusions spouses close relatives burn survivors showed high levels psychological distress first days following admission quarter still reported symptoms clinical range discharge analysis points need offer psychological support guidance family members turn provide effective support burn survivor elsevier ltd isbi rights reserved
droplet electroporation system successfully demonstrated transfection jurkat cell much higher transfection efficiency conventional system advantages superior cell viability comparable throughput user friendly interface productivity proposed system much greater previous microfluidic systems flow cytometry used analysis transfection efficiency high transfection efficiency cell viability droplet electroporation system mainly attributed small size requires lower voltage provides concentrated environment successful transfection jurkat cell using droplet electroporation system broadens applicability proposed technology medical field implication present work future development direction fully automated cell engineering platform discussed elsevier rights reserved
background multiple sclerosis thought cell mediated mechanisms eliciting dysregulated adaptative immune response remain enigmatic objective examine activation profile antigen presenting cells apcs methods total study subjects enrolled including patients suffering relapsing remitting secondary primary progressive inflammatory neurological diseases healthy controls blood monocytes cells stimulated using specific ligands toll like receptors tlrs inflammasomes epstein barr virus ebv particles activation profile determined stimulation flow cytometry human leukocyte antigen antigen related hla luminex assay measuring concentration eight cytokines culture supernatants differences among groups assessed linear model framework results demonstrate relapsing patients exhibit increased expression hla vivo mostly surface cells specific stimulations tlr inflammasomes enhance expression components immunological synapse cytokine secretion without differences categories study subjects conclusion data suggest activation profile cells increased however perception danger signal lymphocytes monocytes seem different patients compared control subjects
ground surface roughness measurement method proposed address current problems use machine vision technology measure roughness calculations complex measurement process largely affected light source based area diffusion regions virtual images formed light source ground surfaces different roughness levels different reference light source containing two base color designed red green color space based color distribution statistical matrices well corresponding overlap indices proposed relationship model overlap index roughness constructed effect light source brightness texture direction relationship model discussed based experimental data results demonstrate surface roughness measurement method based overlap degree color image relatively high accuracy relatively wide measurement range certain degree robust brightness light source texture direction surface roughness measurement method huge potential engineering applications elsevier ltd rights reserved
examined effect modified dialogic reading intervention levels verbal participation vocabulary growth nine preschool children autism spectrum disorder asd using single case design methodology baseline book reading resulted consistently low levels verbal participation followed immediate increase verbal participation dialogic book reading sessions children dialogic reading also resulted greater gains book specific vocabulary children compared baseline book reading sessions improvement verbal participation characterized frequent responses adults question prompts reading improvements children independent initiations comments questions book reading activity observed
building work hambrick simmons mahoney purpose study examine perceptions leisure work family conflict among male ironman participants well strategies support mechanisms used help manage various role demands semi structured interviews conducted males successfully completed least one ironman event males perceptions inter role conflict minimal despite presence similar demands reported hambrick study participants still emphasized need family work role support well specific role management strategies namely scheduling sacrifice role prioritization make ironman aspirations reality impact gender roles perceptions leisure work family conflict also discussed
infrared characteristic simulation target basis true false infrared target recognition development stealth technology imaging features decoy detector close real target easy distinguish target decoy using information acquired single band infrared detector based paper infrared imaging properties target number bands simulated analyzed followed fusing characteristic differences multiple bands true false target classification recognition first construct geometrical model target decoy simple background model infrared radiation built accordance laws infrared radiation relevant laws characteristics target decoy condition different bands analyzed experimental results show proposed multi band target simulation analysis method effectively identify target decoy field view
people post traumatic stress disorder ptsd often suffer memory disturbances particular previous studies suggest ptsd patients perform atypically tests directed forgetting may mediated altered emotional appraisal presented material also special role dissociative symptoms traumatized individuals memory performance suggested investigate issues traumatized immigrants germany item method directed forgetting task pictures presented individually followed instruction either remember forget later recognition memory tested pictures regardless initial instruction overall ptsd group discrimination accuracy lower control group ptsd participants produced fewer hits false alarms groups differ directed forgetting moreover negatively participants evaluated stimuli less able discriminate old new items participants higher dissociation scores particularly poor recognizing forgotten items results confirm ptsd patients general discrimination deficits provide evidence distinct directed forgetting pattern ptsd furthermore data indicate general negatively perceived items discriminated less accuracy positively appraised ones results discussed larger context emotion stress related modulations episodic memory particular focus role dissociative symptoms
generalized signal flow graph forward inverse discrete cosine transform dct based hou recursive algorithm described regular structure generalized signal flow graph enables realize dct inverse dct computation given effectively implementable vlsi chip computer program dct inverse dct computation also presented
emergency contraceptives prevent pregnancy used unprotected sex around time ovulation past years access emergency contraception united states increased women use emerging datamay tailor prescribing based patient weight starting contraception several options oral levonorgestrel oral ulipristal acetate copper intrauterine device ideally women access low cost yet several barriers limited patient provider knowledge cost stocking practices state federal laws exempting providers fromsupplying make difficult integrate time sensitive treatment women reproductive health care
objectives budd chiari syndrome low prevalence life threatening disorder characterized hepatic venous outflow obstruction hepatic venules large hepatic veins inferior vena cava right atrium orthotopic liver transplant considered patients fulminant chronic forms syndrome materials methods fourteen patients received orthotropic liver transplants center september march study retro spectively reviewed prospectively collected data patients results mean age patients years patient female severity liver disease child pugh score patient patients patients mean calculated model end stage liver disease score range cause budd chiari syndrome factor leiden mutation patients polycythemia vera patients factor deficiency patient fulminant essential thrombocytosis patient protein deficiency patients performed transplants patients five grafts obtained deceased donors grafts living related donors mean graft recipient weight ratio patients receiving living donor liver transplant median follow months patient survival rates years conclusions liver transplant option treating budd chiari syndrome cases fulminant presentation cirrhosis living donor liver trans plant viable choice countries procuring organ donations still problem manage long term medical therapy follow patients careful evaluation necessary determine cause budd chiari syndrome anticoagulant antiaggregant therapy remains mainstay treatment syndrome
haizao yuhu decoction hyd used approximately years well known traditional chinese medicine efficacy treatment thyroid related diseases study rapid liquid chromatography tandem mass spectrometry method developed determination liquiritin naringin hesperidin peimine liquiritigenin glycyrrhizic acid bergapten nobiletin osthole glycyrrhetinic acid rat plasma investigate pharmacokinetic profile different hyd prescriptions rat model hypothyroidism differences pharmacokinetic parameters among groups compared student test pharmacokinetic profile liquiritin naringin hesperidin peimine liquiritigenin glycyrrhizic acid bergapten nobiletin osthole glycyrrhetinic acid showed significant differences haizao gancao anti drug combination herbs hyd results may contribute rational clinical use hyd reveal compatibility profile haizao gancao anti drug combination
bright light interventions successfully used reduce depression symptoms patients seasonal affective disorder depressive disorder frequently occurring seasons reduced daylight availability yet little known light exposure impacts human brain function instance risk taking process affected depressive disorders examined modulatory effects bright light exposure brain activity risk taking task thirty two healthy male volunteers living greater copenhagen area received weeks bright light intervention winter season adopting double blinded dose response design bright light applied minutes continuously every morning individual dose varied whole brain functional mri performed bright light intervention probe intervention modifies risk taking related neural activity two choice gambling task also assessed whether inter individual differences serotonin transporter linked polymorphic region httlpr genotype influenced effects bright light intervention risk processing bright light intervention led dose dependent increase risk taking group relative non group bright light intervention enhanced risk related activity ventral striatum head caudate nucleus proportion individual bright light dose augmentation effect light exposure striatal risk processing influenced httlpr genotype study provides novel evidence healthy non depressive individuals bright light intervention increases striatal processing risk dose dependent fashion findings provide converging evidence risk processing sensitive bright light exposure winter elsevier inc rights reserved
purpose competition challenges facing construction firms recent recession brought risk management fore people minds examination difficulties implementing small medium enterprises smes construction industry relatively untouched paper aims discuss issues design methodology approach part going research facilitate processing aimed improving competitiveness smes difficulties implementation identified literature review implementation smes postal questionnaire sent smes experience construction management findings smes responding highlighted main difficulty experienced scale process meet requirements none available standards explain fundamental principle applying situations smes find difficulty exacerbated lack management skills knowledge adoption tools techniques identify analyse business risks originality value identified difficulties considered develop process facilitate process within smes
sustainable water management important global action alleviate growing pressure water resources way balance socio economic environmental water needs irrigation green roofs urban green infrastructures often negative connotation water management context especially case semi arid regions water scarcity summer water needs compromise public support urban irrigation systems however irrigating green roofs also beneficial improves plant survival temperature control information green roof irrigation still scarce review attempts draw attention alternative water sources water conservation strategies order make green roof irrigation practices sustainable suggestions sustainable green roof irrigation showed water conserved adapting irrigation requirements targeting vegetation materials using alternative irrigation sources gray water rainwater harvesting controlling monitoring irrigation regimes based deficit irrigation strategy irrigation specifications green roofs different climates proposed became clear irrigation essential establishment first growing season types green roof climates considered afterwards irrigation necessary green roofs semi arid climates advised small amounts climates public awareness sustainable water consumption promoted green roofs designed carefully irrigation practices sustainable long term contribute better urban life quality elsevier ltd rights reserved
human defensin hbd cationic antimicrobial peptide potent bactericidal activity vitro hbd produced response pathogen challenge modulate immune responses amplified recognition self dna human plasmacytoid dendritic cells previously reported show hbd preferentially enhances response bacterial dna mouse flt induced dendritic cells fldcs human peripheral blood mononuclear cells show effect mediated tlr although hbd significantly increases cellular uptake coli self dna mouse fldcs response bacterial dna enhanced liposome transfection also increases uptake bacterial dna amplifies tlr dependent response contrast hbd lipofection self dna enhances inflammatory signaling response predominantly tlr independent together data show hbd role innate immune mediated response pathogen dna increasing inflammatory signaling promoting activation adaptive immune system via antigen presenting cells including dendritic cells therefore data identify additional immunomodulatory role copy number variable defensin relevance host defence infection indicate potential inclusion hbd pathogen dna based vaccines
address boundary integral equation bie approach analysis gas dissipation near vacuum micro electro mechanical systems mems inspired analogy radiosity equation computer graphics discuss efficient way compute visible domain integration moreover tackle issue near singular integrals developing set analytical formulas planar polyhedral domains finally validation experimental results taken literature presented
previous research shown negative relationship adverse childhood events aces health resiliency among general population examined associations among children autism purpose determine prevalence aces among children autism aces associated resiliency health methods quantitative analysis conducted using data national survey children health results children autism experience significantly aces peers negatively associated health however resiliency significantly associated aces population aces disproportionately affect children autism negatively associated health resiliency investigation children autism experience aces maintain resiliency warranted
development science technology formation comprehensive multidisciplinary technology emergence new permanent magnetic actuator electronic operation synchronous technology field pressure achieve hardware basis order meet high reliability vacuum circuit breaker operation country depth study gradually promote electronic control systems match permanent mechanism article key technology digital signal processing theory research motor motor control experimental results show effectiveness method better reflect characteristics digital control system digitizing motion brushless motor control engineering applications useful explore try
obesity one major health issues united states consumption diets rich energy notably fats sugars high fat high sugar diet hsd linked development obesity popular dietary approach weight loss reduce fat intake obesity research traditionally uses low high fat diets limited investigation potential detrimental effects low fat high sugar diet hsd body fat accumulation health therefore present study investigated effects hsd hsd microbiota composition gut inflammation gut brain vagal communication body fat accumulation specifically tested hypothesis hsd changes gut microbiota induces gut inflammation alters vagal gut brain communication associated increased body fat accumulation sprague dawley rats fed hsd hsd control low fat low sugar diet lsd weeks body weight caloric intake body composition monitored daily fecal samples collected baseline days dietary switch four weeks blood tissues gut brain liver nodose ganglia sampled hsd hsd fed rats displayed significant increases body weight body fat compared lsd fed rats rrna sequencing showed hsd hsd fed animals exhibited gut microbiota dysbiosis characterized overall decrease bacterial diversity increase firmicutes bacteriodetes ratio dysbiosis typified bloom clostridia bacilli marked decrease lactobacillus spp hsd fed animals showed specific increase sutterella bilophila proteobacteria abundances associated liver damage expression pro inflammatory cytokines beta tnf alpha upregulated cecum levels tight junction protein occludin regulated hsd hsd fed rats hsd hsd fed rats also exhibited increase cecum serum levels lipopolysaccharide lps pro inflammatory bacterial product immunofluorescence revealed withdrawal vagal afferents gut site termination nucleus solitary tract nts hsd hsd rats moreover significant microglia activation nodose ganglia contain vagal afferent neuron cell bodies hsd hsd rats taken together data indicate similar hsd consumption hsd induces dysbiosis gut microbiota increases gut inflammation alters vagal gut brain communication changes associated increase body fat accumulation elsevier inc rights reserved
polynomial global approach time series analysis costly computationally speaking step finding fitting polynomial present two routines improve forecasting first algorithm greatly improves situation introduced implemented heart procedure implemented specific routine performs mapping great efficiency comparison similar procedure times package developed carli enormous gain efficiency increasing accuracy obtained another development work establishment level confidence global prediction statistical test evaluating minimization performed suitable program presented article applies shapiro wilk test checking normality distribution errors calculates expected deviation development employed observed simulated time series illustrate performance obtained program summary program title linmapts catalogue identifier afaj program summary url http cpc qub ukisummaries afaj html program obtainable cpc program library queen university belfast ireland licensing provisions standard cpc licence http cpc qub licence licence html lines distributed program including test data etc bytes distributed program including test data etc distribution format tar programming language maple computer capable running maple operating system capable running maple tested windows windows windows ram bytes classification nature problem time series analysis improving forecast capability solution method basis solution method result published restrictions global variables used generated map vectors employed global mapping normality test applicable unusual features many polynomial coefficients calculated values different distinct computers discrepancies affect significantly accuracy forecasting running time seconds required usual applications elsevier rights reserved
ankylosing spondylitis autoimmune disease chronic inflammatory arthritis critical role methylation biology immunocytes increasingly surveyed discover disease etiology dna methyltransferase dnmt enzyme establishes regulates patterns methylated cytosine residues aim current investigation unveil methylation circumstances cpg sites dnmt promoter could affect mrna expression level gene peripheral blood mononuclear cells pbmcs patients pbmcs isolated whole blood patients healthy individuals total rna dna contents leukocytes extracted afterward quantitative analysis carried real time pcr using sybr green pcr master mix finally determine methylation level pcr products bisulfite treated dna patients controls sequenced compared healthy controls expression level dnmt patients significantly downregulated methylation dnmt promoter significantly higher patients comparison controls negative correlation methylation expression level dnmt observed patients methylation expression level dnmt correlate clinical manifestations considering observation decreased expression level dnmt associated hypermethylation dnmt promoter pbmcs patients survey suggests dysregulation dnmt expression altered methylation level target genes would probably contribute development
witnessing transition petascale exascale computing experience teaching students scientists adopt distributed computing infrastructures computational science geoffrey moore coined chasm visionaries computational science early majority scientific pragmatists using funded drihm project distributed research infrastructure hydro meteorology case study observe innovative research infrastructures difficulties accepted scientific pragmatists infrastructure scientific services mainstream enough excellence workforce however achieved tools available also used paper report chasm exhibited drihm case partially crossed learned experience general cases elsevier rights reserved
verification methodology described evaluated formally determine uncertain linear systems stability digital controllers considerations implementation aspects particular methodology combined digital system verifier dsverifier verification tool employs bounded model checking based satisfiability modulo theories check stability digital control systems uncertainty dsverifier determines control system stability considering plant interval variation set together finite word length fwl effects digital controller implementation dsverifier checks robust non fragile stability given closed loop system proposed methodology respective tool evaluated considering non fragile control examples literature experimental results show approach used study able foresee fragility problems robust controllers could overlooked existing approaches due underestimating fwl effects
background complement system implicated pathogenesis systemic sclerosis ssc goal present study evaluate improved complement biomarkers ssc methods presence reflecting activation classical lectin pathways cbbbp corresponding activation alternative pathway soluble terminal complement complexes complement pathways measured plasma samples enzyme linked immunosorbent assay correlated clinical parameters study included patients limited cutaneous ssc diffuse cutaneous ssc well matched healthy controls patients rheumatoid arthritis psoriatic arthritis ankylosing spondylitis skin kidney biopsies selected patients stained detect deposited marker local complement activation results biomarkers activation complement pathways increased ssc compared healthy controls similar rheumatic diseases patients ssc divided subgroups distinct pattern complement markers observed individuals scleroderma renal crisis src functional assay confirmed significant decrease complement haemolytic activity src non src patients indicating complement consumption detected glomerular deposits patients src conclusions data indicate complement activation important feature src
background studies adults show associations hypofunctional seven repeat allele dopamine receptor gene drd increased eating behaviour obesity particularly females examined whether associated total caloric intake food choices pre schoolers methods four year old children taking part birth cohort study canada administered snack test meal laboratory setting mothers also filled food frequency questionnaire address childrens habitual food consumption total caloric individual macronutrient intakes snack meal specific types foods reported food diaries compared across allele carriers non carriers using current bmi variate results found significant sex genotype interactions fat protein intake snack test post hoc testing revealed girls boys carriers ate fat protein non carriers based food diaries across sexes carriers consumed portions ice cream less vegetables eggs nuts whole bread suggesting less healthy pattern habitual food consumption conclusion allele drd influences macronutrient intakes specific food choices early four years age specific pattern results suggests prior associations allele adult overeating obesity may originate food choices observable preschool years longitudinal follow children help establish relevance findings obesity risk prevention elsevier ltd rights reserved
work energy harvesting performance piezoelectric curved energy generator thin layer unimorph driver thunder studied via experimental analytical methods analytical model thunder created based linear mechanical electrical constitutive law piezoelectric material linear elastic constitutive law substrate euler bernoulli beam theory linear modal functions rayleigh ritz approach used obtain reduced mechanical electrical coupled modulation equations analytical model verified experimental results experimental analytical results thunder power output power output rectifier bridge capacitor well power output microcontroller energy harvesting circuit reported based theoretical model analytical solution power derived terms vibration amplitude frequency electrical load harvest energy low frequency vibration source piezoelectric generator requires piezoelectric device possessing low resonance frequency good flexibility thunder developed langley research center exhibits high power used energy generator large displacement used actuator compared less flexible pzt although thunder difficult model thunder better vibration absorption capacity higher energy recovery efficiency effect thunder radius curvature energy harvesting efficiency mainly investigated set thunder radius curvature dynamic tuning parameter tune piezoelectric generators frequency source excitation frequency
study elaborated process management quality control three typical major isolation retrofit projects construction stage base seismic isolation migrating building load entrusted temporary pile seismic isolation devices process management support ground depth set parameter process period including building area building load discussed quality control impact process generated difference vertical displacement load migration temporary supporting piles properties purpose study analyze impact construction applying temporary pile construction process seismic isolation devices
looking beyond tickbox approach green rating systems apply north american climatic criteria brazilian context joana carla soares goncalves professor environmental design faculty architecture urbanism university sao paulo advocates far reaching way forward sustainability brazil
gentry fully homomorphic encryption scheme sparse subset sum problem sssp used big set included public key implementation variant reduce size public key gentry halevi used specific form sssp constructed geometric progressions study authors solve gentry halevi sparse subset sum challenges first time owing aggressive choice parameters process fairly easy done simply modifying lattice based attack experiment shows even large challenge solved within two days second contribution considering attacks hybrid attack combining meet middle attack lattice based attack provide new condition hard instances sssp geometric progressions
article examines coordination speech gesture teachers definition talk vocabulary explanations addressed language learners analyzing one esl teacher spoken definitions study demonstrates details unfolding talk teacher crafts choreographs definitions moment moment attending student linguistic needs study draws upon mcneill notion gesture speech expressiveness mcneill levy idea gestural cohesion kendon notion turn contextualization gesture study identifies three major functional roles gesture reinforcing meaning verbal utterances disambiguating meaning lexical items establishing gestural cohesion across turns talk fine grained analysis five excerpts study contributes understanding interactional informational aspects gesture second language teaching article discusses implications study gesture general role gesticulations providing comprehensible input second language learners particular
osteoporosis interventions targeting older australians clinicians conducted part national quality improvement program underpinned behavioural theory stakeholder engagement uptake bone mineral density bmd tests among targeted men women increased interventions sustained increases osteoporosis treatment observed among men targeted purpose educational interventions incorporating patient specific prescriber feedback improved osteoporosis screening treatment among risk patients clinical trials evaluated nationally study assessed uptake bmd testing osteoporosis medicines following two national australian quality improvement initiatives targeting women years men years risk osteoporosis methods administrative health claims data used determine monthly rates bmd testing initiation osteoporosis medicines months post intervention among targeted men women compared older cohorts men women log binomial regression models used assess differences groups results patients targeted targeted twofold increase bmd testing intervention among targeted patients compared controls initiation osteoporosis medicines increased among men targeted among men targeted compared older controls initiation osteoporosis medicines among targeted women similar older controls conclusion programs underpinned behavioural theory stakeholder engagement target primary care clinicians patients improve osteoporosis screening management national level
basic idea nanofluid enhance thermal conductivity base fluid however classical nanofluid models drastic limitations describe class fluids certain microscopic characters arising microrotation local structure fluid elements therefore present work one infrequent contributions describes microrotation microinertia characteristics nanofluids exactly work unsteady free convection flow micropolar nanofluids investigated vertical plate five types oxide nanoparticles namely copper oxide titanium oxide alumina oxide iron oxide graphene oxide suspended three different types fluids water kerosene engine oil exact solutions governing problem obtained laplace transform method solutions conventional regular nanofluid also recovered special case temperature graphene oxide suspended micropolar nanofluid higher oxide nanoparticles based nanofluids published elsevier
netherne hospital surrey perhaps prestigious site history british art therapy associated key figures edward adamson eric cunningham dax whose pioneering work involved setting large studio psychiatric patients create expressive paintings little known however work designated scientist psychiatric research hungarian jewish emigre francis reitman charged overall scientific analysis artistic products studio schooled biological psychiatric tradition ladislas meduna budapest prior exile maudsley hospital committed treatments leucotomy electro convulsive therapy ect reitman unusual candidate research unconscious processes behind art psychosis yet authored two highly popular widely reviewed books analyses abundant artistic output created patients schizophrenic diagnoses netherne psychotic art insanity art culture reitman compared schizophrenic images produced artists influence mescaline examined artistic output patients undergone leucotomy article draws archival materials reitman original research publications order reconstruct theory schizophrenic art within complex context postwar british psychiatry negotiating biologically reductive understandings freudian jungian psychoanalytic categories ultimately synthesizing concepts also analyses reitman implicit theory therapeutic mechanism art treatment psychiatric patients
experiment conducted investigate effects dietary fibre content weaning age oil clostridium perfringens proliferation caecum fattening mortality growing rabbits farmed facility epizootic rabbit enteropathy experiment consisted factorial arrangement two weaning ages days days two levels dietary neutral detergent fibre assayed heat stable amylase expressed exclusive residual ash andfom controls made two consecutive experimental periods differed hygienic environmental conditions modifying intensity cleaning disinfection farm previous trial interaction detected among independent variables studied perfringens enumeration caecal contents minimal values trait obtained non medicated animals reared clean environment especially weaned later age fed diet lower fibre content treatments studied also led variation fattening mortality highly positively correlated average perfringens caecal counts combination treatments results current study indicate high counts perfringens caecum used indicator epizootic rabbit enteropathy suggest strategies designed control proliferation caecum might help limit fattening mortality rabbit fed diets medicated antibiotics elsevier rights reserved
background evidence based practice ebp implementation represents strategic change organizations requires effective leadership alignment leadership organizational support across organizational levels need combining leadership development organizational strategies support organizational climate conducive ebp implementation leadership organizational change implementation loci intervention includes leadership training workgroup leaders ongoing implementation leadership coaching degrees assessment strategic planning top middle management regarding support workgroup leaders developing positive ebp implementation climate methods test loci intervention take place conjunction implementation motivational interviewing substance use disorder treatment programs california usa participants include agency executives program leaders approximately treatment staff loci tested using multiple cohort cluster randomized trial randomizes workgroups programs within agency either loci webinar leadership training control condition three consecutive cohorts loci intervention months webinar control intervention takes place months cohort web based surveys staff supervisors used collect data leadership implementation climate provider attitudes citizenship audio recordings counseling sessions coded fidelity unit analysis workgroup randomized site within agency care taken located workgroups assigned condition avoid contamination hierarchical linear modeling hlm used analyze data account nested data structure discussion loci developed feasible effective approach organizations create positive climate fertile context ebp implementation approach seeks cultivate sustain effective general implementation leadership well organizational strategies support remain study ended development positive implementation climate result positive service provider attitudes behaviors related use ultimately higher fidelity use
conception deployment cost effective picture archiving communication systems pacs concern small medium medical imaging facilities research environments developing countries healthcare institutions financial constraints specificity scenarios contribute low adoption rate pacs environments furthermore advent ubiquitous computing new initiatives improve healthcare information technologies data sharing ihe xds pacs must adapt quickly changes paper describes dicoogle software framework enables developers researchers quickly prototype deploy new functionality taking advantage embedded digital imaging communications medicine dicom services full fledged implementation pacs archive amenable extension due plugin based architecture box functionality enables exploration large dicom datasets associated metadata characteristics make proposed solution interesting prototyping experimentation bridging functionality deployed applications besides advanced mechanism data discovery retrieval based dicom object indexing enables detection inconsistencies institution data processes several use cases benefited approach radiation dosage monitoring content based image retrieval cbir use framework support classes targeting software engineering clinical contexts
basic computer language widely used industry education many computer programming beginners choose first computer language learn difficult beginners especially high school students learn programming learning supporting environment enough research proposes provit programming visualization tool web learning supporting environment programming education provit web many features used write run check programs without installing ide especially used lecture show execution program step step detect run time error often seen beginner program web provit used programming course author university paper reports design implementation result experimental use provit web
baseline design european extremely large telescope features telescope meter class primary mirror consisting hexagonal segments measurement machine design presented based non contact single point scanning technique capable measuring form error segment nanometer uncertainty fast low operational costs implementation tactile precision probe eliminates need cmm earlier segment manufacturing process preliminary assessment show nanometer level uncertainty calibration
salinity gradient solar ponds act integrated thermal solar energy collector storage system temperature difference upper convective zone lower convective zone salinity gradient solar pond range degrees temperature bottom pond reach degrees low grade heat degrees solar ponds currently converted electricity organic rankine cycle engines thermoelectric generators operate low temperature differences good candidate replace organic rankine cycle engines power generation salinity gradient solar ponds temperature difference solar pond used power thermoelectric generators electricity production paper presents experimental investigation thermoelectric generators heat exchanger system designed powered hot water lower convective zone solar pond cold water upper convective zone solar pond results obtained indicated significant prospects system generate power low grade heat remote area power supply systems
mobile communication technology plays increasingly pervasive role everyday life study examined one aspect role specifically effects mobile device use micro interactions pedestrians approached passed confederate participants observed group mobile device control condition look look smile look smile greeting lsg factorial design study measuring participants looks smiles nods greetings toward confederates log linear analyses dependent measures provided qualified support predicted decreased responsiveness mobile device users specifically group condition interaction smiles showed significantly fewer mobile device users controls smiled confederates lsg condition addition group sex participant interaction greetings indicated significantly fewer female mobile device users offered greetings males females conditions processes potentially mediating effects discussed broader influence mobile devices micro interactions pedestrians considered
computer graphics advent latest technology last decades paper webgl framework used create virtual tour university mauritius web virtual tour designed provide viewers life like view existing location using advanced simulation techniques creating loading manipulating objects sketchup tool models built converted webgl format achieved use exporter objects file moreover tested especially loading simple average complex objects without texture system capability support multi users navigation virtual environments
study empirically tested effects use third person perceptions context stock market using sample professional stock traders members lay public findings show people perceived anonymous information recommending stocks internet greater influence others additionally participants demonstrated third person perception others novice investors little knowledge experience stock trading others presumed experienced investors professional stock traders perceived greater influence others lay public also found support relationship third person perceptions attitudes toward support warnings anonymous information
indiana recently passed legislation allowing local governments establish syringe exchanges effectiveness syringe exchange programming established dearth studies associated policy adoption implementation study documents experiences indiana counties engaged process establishing syringe exchange programming new state law mixed method qualitative exploratory case study conducted may april observed rapid widespread policy adoption interest yet counties reported significant policy ambiguity epidemiologic resource capacity issues emergence health commons involving information tangible resource sharing networks allowed institutional rearrangement midst resource scarcity however rearrangement appeared central threat policy adoption implementation given state structural barriers emerging commons could critical policy success factor would achieve efficiencies possible current resource environment help achieve institutional rearrangement improvement population health several recommendations improvement offered
robust optimal sun pointing control strategy large geostationary solar power satellite sps addressed paper sps considered huge rigid body sun pointing dynamics firstly proposed state space representation perturbation effects caused gravity gradient solar radiation pressure microwave reaction investigated perform sun pointing maneuvers periodically time varying robust optimal lqr controller designed assess pointing accuracy control inputs noted reduce pointing errors disturbance rejection technique combined proposed lqr controller recursive algorithm proposed solve optimal lqr control gain simulation results finally provided illustrate performance proposed closed loop system iaa published elsevier ltd rights reserved
paper focuses problem distributed composite hypothesis testing network sparsely interconnected agents small section field modeling parametric alternatives observable agent recursive generalized likelihood ratio test glrt type algorithm distributed setup consensus plus innovations form proposed agents update parameter estimates decision statistics simultaneously processing latest sensed information innovations information obtained neighboring agents consensus paper characterizes conditions testing algorithm design parameters ensure probabilities decision errors decay zero asymptotically large sample limit finally simulation studies presented illustrate findings
objective challenging differential diagnosis background basal ganglia calcification bgc rare sporadic hereditary central nervous system cns abnormality characterized symmetric asymmetric calcification basal ganglia case report report case year old gypsy female admitted tetanic seizure history polyneuropathy restless leg syndrome retinopathy diabetes hyperlipidemia osteoporosis consecutive hyperkyphosis cervicalgia lumbalgia struma nodosa requiring thyroidectomy consecutive hypothyroidism adipositas resection vocal chord polyp arterial hypertension coronary heart disease atheromatosis aorta peripheral artery disease chronic obstructive pulmonary disease steatosis hepatis mild renal insufficiency long term hypocalcemia hyperphosphatemia impingement syndrome spondylarthrosis lumbar spine hysterectomy history clinical presentation suggested mitochondrial defect also manifested hypoparathyroidism fanconi syndrome resulting bgc substitution calcium tetanic seizures occurred conclusions patients bgc investigated mitochondrial disorder mitochondrial disorder may also manifest tetanic seizure
purpose studies report role leukotrienes pathogenesis atopic dermatitis suggest rationale use leukotriene receptor antagonist ltra treatment atopic dermatitis study aimed evaluate treatment effectiveness montelukast children atopic dermatitis methods fifty four children ages years moderate severe atopic dermatitis enrolled group received montelukast weeks followed crossover weeks placebo week washout period group reversed administration according randomized double blind placebo controlled crossover design scoring atopic dermatitis scorad index urinary leukotriene lte eosinophil derived neurotoxin edn assessed every visit results forty three patients males completed study although scorad index decreased groups statistically significant difference montelukast placebo level urinary lte decreased taking montelukast compared placebo statistically significant difference changes urinary edn taking montelukast placebo significant difference analyzing scorad indices urinary lte edn could prove effectiveness montelukast atopic non atopic high ecp ecp subgroups conclusions statistically significant difference clinical improvement biomarkers montelukast placebo treatment therefore conventional treatments skin care infection control might important strategies treatment atopic dermatitis
veterans health administration vha mandated nationwide implementation interprofessional team based care general mental health setting officially endorsed collaborative care model guide coordinated anticipatory care delivered teams front line clinic staff major stakeholders whose practices directly affected implementation may may view teams useful feasible practice objective examine perspectives delivering team patient care order understand system level efforts best support transition care conventional provider patient care conducted semi structured interviews staff general mental health clinics across three different vha medical facilities interview questions focused asking care organised delivered clinic experiences collaborating staff clinic handles changes four recurrent themes identified navigating workplace supervision organisation role structures continuing professional growth relationships delivering patient focused care education connection resources utilising information technology communication panel based management quality improvement efforts rarely discussed interviews results indicate staff endorsement implementation interprofessional care teams general mental health settings may strengthened associated efforts targeted enhancing experiences aligned emergent themes
new nonisolated multiinput multioutput boost converter proposed paper converter applicable hybridizing alternative energy sources electric vehicles fact hybridization energy sources advantages different sources achievable converter loads power flexibly distributed input sources also charging discharging energy storages input sources controlled properly proposed converter several outputs different voltage levels makes suitable interfacing multilevel inverters using multilevel inverter leads reduction voltage harmonics consequently reduces torque ripple electric motor electric vehicles also electric vehicles using motor least two different voltage levels one ventilation system cabin lightening supplying electric motor proposed converter one inductor depending charging discharging states energy storage system ess two different power operation modes defined converter order design converter control system small signal model operation mode extracted validity proposed converter control performance verified simulation experimental results different operation conditions
background prevalence clinical characteristics neonatal candidemia poorly understood western china aim study evaluate epidemiological features neonatal candidemia liuzhou maternity child healthcare hospital methods retrospective case control study conducted january november electronic databases reviewed data candida species isolated blood cultures candidemia incidence risk factors mortality extracted univariate multivariate logistic regression analysis performed identify risk factors associated candidemia results year period candidemia identified newborns incidence rate per admissions prolonged antibiotic therapy duration odds ratio confidence incidence total parenteral nutrition neurodevelopmental impairment associated increased odds candidemia development infants value respectively overall mortality rate candidemia group conclusions prolonged duration antibiotic therapy presence total parenteral nutrition neurodevelopmental impairment major risk factors associated neonatal candidemia study highlights importance early detection diagnosis treatment neonatal candidemia
line growing need data information transmission safe quick manner researches image protection security combination cryptographic compression techniques begin take form combination two methods may include three categories based process sequences first category cryptographic technique followed compression method focuses image security reduction size data second combination compression technique followed cryptographic method advantage compression technique lossy lossless combination third category compression cryptographic technologies single process either partially form compressive sensing provides good data safety assurance low computational complexity eligible enhancing efficiency security data information transmission
background prenatal exposure endocrine disrupting compounds edcs previously shown alter epigenetic marks objectives work explore whether prenatal exposure mixtures xenoestrogens potential alter placenta epigenome studying dna methylation retrotransposons surrogate global dna methylation methods biomarker total effective xenoestrogen burden texb measured placentas participants longitudinal inma project dna methylation quantitatively assessed bisulfite pyrosequencing different retrotransposons including different long interspersed nuclear elements lines short interspersed nuclear elements sines human endogenous retroviruses hervs associations tested using linear mixed effects regression models sex interaction evaluated results significant sex interaction observed aluyb value interaction significant bonferroni corrected value threshold boys highest texb alpha levels exposure third tertile presented average decrease methylation compared first tertile value significant effects found girls value conclusions findings suggest boys may susceptible effect exposure xenoestrogens prenatal development producing shifts dna methylation certain sensitive genomic repetitive sequences tissue important fetal growth development elsevier ltd rights reserved
upon recognition specific molecular patterns microbes host cells trigger innate immune response culminates production type interferons proinflammatory cytokines chemokines restricts pathogen replication spread within host stage response stimulatory inhibitory signals regulate magnitude quality character response positive regulation promotes antiviral state control eventually clear infection whereas negative regulation dampens inflammation prevents immune mediated tissue damage overexuberant innate response lead cell tissue destruction development spontaneous autoimmunity retinoic acid inducible gene rig like receptors rlrs rig melanoma differentiation associated gene mda belong family cytosolic host rna helicases recognize distinct nonself rna signatures trigger innate immune responses several rna viruses signaling essential adaptor protein mitochondrial antiviral signaling mavs rlr signaling pathway tightly regulated maximize antiviral immunity minimize immune mediated pathology review highlights contemporary findings negative regulators rlr signaling pathway specific focus proteins biological processes directly regulate rig mda mavs signaling function
project aims providing materials engineering fraternity simple effective interface using ipython operate quantum espresso open source code materials simulation first principles code using density functional theory plane waves pseudo potentials ability predict material properties ipython notebook interface uses scope following libraries atomic simulation environment ase matplotlib scipy numpy pyspglib elastic newly developed library nipy advanced predict properties nipy advanced latest version nipy latest version incorporates features take care input parameters supported pwscf phonon packages quantum espresso thermo mechanical properties nuclear materials different magnetic metallic behavior studied using nipy advanced demonstrate thermo mechanical properties non magnetic insulator like silicon carbide thoria materials future nuclear reactor applications
work presents adaptive structure inspired spider webs behavior investigate dynamic properties performance system numerical models developed examine effects pretension radial strings young modulus damping ratio natural frequency total energy system experimental study conducted validate theoretical results stepper motors controlled microcontroller utilized increase pretension radial strings web order tune web energy absorption ability demonstrated pretension young modulus damping ratio radial strings significantly affect natural frequency total energy full damaged webs also shown increasing pretension radial strings compensates loss stiffness due damaged strings finally shown controlling pretension radial strings provide higher energy absorption capability spider web
background generalised joint hypermobility gjh suggested aetiological factor knee injuries adolescents adults presumed gjh causes decreased joint stability thereby increasing risk knee injuries challenging situations like jumping landing aim study extent risk knee injuries children gjh knee hypermobility methods total children years tested twice spring beighton tests hypermobility scoring system gjh classified cut point test rounds basis weekly cell phone surveys knee pain children requiring clinical examination seen traumatic overuse knee injuries registered icd diagnoses logistic regression poisson regression models robust standard errors used examine association gjh knee injuries taking account clustering school class levels results totally children classified gjh test rounds overuse knee injuries frequent injury type mainly apophysitis groups patella femoral pain syndrome control group traumatic knee injuries distortions contusions frequent groups resp besides traumatic lesions knee tendons muscles control group significant association found overuse knee injuries gjh without knee hypermobility resp traumatic knee injuries gjh without knee hypermobility resp conclusions apophysitis distortions contusions frequent knee injuries despite relatively large study number children gjh knee injuries low significant increased risk knee injuries group questions whether gjh clinically relevant risk factor knee injuries school children aged years fluctuation individual child status gjh test rounds observed suggesting inter intra tester reproducibility well growth may considered important confounders future studies children gjh
tyrosine based electrochemical analysis induced aggregation beta amyloid beta peptide implicated alzheimer disease pathogenesis isoforms familial mutations naturally occurring ser phosphorylation carried square wave voltammetry carbon screen printed electrodes electrooxidation peak current directly compared size determined dynamic light scattering dls beta aggregates formed analyzed samples presence ions amount peptide soluble resistant sedimentation upon application centrifugal force fraction demonstrated substoichiometric ion concentrations decrease electrooxidation current ion concentration may attributed depletion peptide pool constituting soluble fraction stoichiometric ion concentration contribution peak current large sedimentation prone beta aggregates starts progressively dominate relative values peak current potentially serve estimate relative number soluble peptide beta preparation application direct electrochemistry induced aggregation beta isoforms concurrently dls allowed reveal specific features aggregation process determined presence mutations modification direct electrochemistry appears present method complementary methods monitoring induced beta aggregation based aggregate detection elsevier rights reserved
last years considerable increase number studies development multiplier circuits based spiking neural systems aim taking advantage intrinsic distributed parallel computing characteristics nevertheless efforts difficulties adequately exploiting parallel data processing designed process input data using sequential protocol thus suffer resulting increase processing time paper develops novel parallel multiplier based spiking neural systems capable multiplying two natural numbers many digits parallel proposed method employs divide conquer strategy segmenting numbers units tens hundreds thousands etc optimize processing time arithmetic operations every two units treated single neuron calculate sequentially use one neuron perform sequential multiplication represents best improvement terms number neurons reported date elsevier rights reserved
therapy genetically modified autologous cells shown great promise cancer therapy efficient control hepatitis virus hcv infection cytotoxic cells ctl pivotal persistence activated cells may lead liver toxicity anti hcv cell receptors tcrs recognizing hcv nonstructural viral peptide target examined mrna transfection human peripheral blood lymphocytes pbls derived healthy donors well chronically infected hcv patients immunological analysis shows ctls expressing specific tcr reduced hcv rna replication noncytotoxic mechanism specific tcr redirected ctls polyfunctional inhibited hcv rna replication antigen specific cytotoxicity transcriptome signatures two types ctl responses revealed uniquely expressed gene clusters upon encountering hepatoma target cells presenting endogenously expressed hcv proteins tcr induced rapid expression apoptotic signaling pathways formation embryonic gene clusters whereas nsa tcr activation induced extended proliferative metabolic pathways hcv target cells survived results provide detailed insights basic hcv cell immunology clinical relevance redirecting cells target virally infected hepatoma cells importance due protective ability hcv specific cells hepatotoxic potential possess great need understanding functional aspects hcv specific cells circumvent low level precursor frequency patients engineered primary cells mrna tcr vectors confer hcv specificity new cells hcv tcrs differ antigen specificity polyfunctionality examined mrna tcr engineering peripheral blood lymphocytes healthy donors chronically infected hcv patients resulted strikingly high levels hcv tcr expression hcv specific responses cytotoxicity response polyfunctional cell activation caused hepatotoxicity rapid induction apoptotic signaling pathways noncytotoxic cell activation showed extended proliferative metabolic pathways persistence hcv target cells results provide detailed insights basic hcv cell immunology clinical relevance immune protection hcv associated diseases
nonadiabatic dynamics simulation electronically excited states research area fundamental importance providing support spectroscopy explaining photoinduced processes predicting new phenomena variety specialties basic physical chemistry molecular biology materials engineering demands field however quickly growing development surface hopping based density functional theory dft major advance field contribution surface hopping approach methods computation excited states based dft connection methodologies diverse implementations reviewed shortcomings methods critically addressed number case studies diverse fields surveyed
leaving composite liner exposed extended period sometimes lead slope bentonite erosion geosynthetic clay liners gcls laboratory study examines number factors affect erosion bentonite particles imposed flow water one particular geotextile encased needle punched gcl factors examined include effect initial wet dry cycle water chemistry flow rate slope prior cation exchange effect drying phase test cycle erosion observed unless gcl hydrated dried create wet dry cycle critical factor found water chemistry erosion observed tap water ppm calcium cycles flow hour tests simulating evaporation condensation water exposed composite liner imposing deionized water gcl surface developed erosion holes within cycles elsevier ltd rights reserved
aims investigate hypothesis presence transient morning masticatory muscle pain young healthy sleep bruxers sbr associated sex related differences sleep electroencephalographic eeg activity methods data morning masticatory muscle pain sleep variables obtained visual analog scales second night polysomnographic recordings nineteen normal control ctrl subjects age sex matched tooth grinding sbr differences sleep macrostructure stage distribution duration number sleep stage shifts number rhythmic masticatory muscle activity rmma events hour eeg activity analyzed blind subject status influence pain gender sbr ctrl subjects assessed fisher exact test mann whitney test two sample test analysis variance anova results low intensity morning transient orofacial pain reported sbr sex difference rmma event frequency higher ctrl subjects hour hour sbr fewer sleep stage shifts irrespective sex pain status female sbr significantly lower theta alpha eeg activity compared female ctrl subjects irrespective pain conclusion female sbr lower theta alpha eeg activity irrespective transient morning pain
accurate reliable identification damage modern engineered structures essential timely corrective measures vibration based damage prediction studied extensively virtue global damage detection ability simplicity practical implementation however due noise damping effects accuracy method inhibited direct peak detection dpd utilized determine resonant frequency shifts research investigates alternative method detect frequency shifts caused structural damage based utilization strongly nonlinear bifurcation phenomena bistable electrical circuits coupled piezoelectric transducers integrated structure shown frequency shift predictions proposed approach significantly less susceptible error dpd realistic noise damping levels distort shifting resonance peaks implemented alongside adaptive piezoelectric circuitry tunable inductance new method yields damage location severity identification significantly robust accurate results obtained following dpd approach
background patients myalgic encephalomyelitis chronic fatigue syndrome cfs unable activate brain orchestrated endogenous analgesia descending inhibition response exercise physiological impairment currently regarded one factor explaining post exertional malaise patients autonomic dysfunction also feature cfs objectives study aims examine role autonomic nervous system exercise induced analgesia healthy people cfs studying recovery autonomic parameters following aerobic exercise relation changes self reported pain intensity study design controlled experimental study setting study conducted human physiology lab vrije universiteit brussel methods twenty women cfs healthy sedentary controls performed submaximal bicycle exercise test known aerobic power index continuous cardiorespiratory monitoring exercise measures autonomic function heart rate variability blood pressure respiration rate performed continuously minutes self reported pain levels registered relation autonomous parameters self reported pain parameters examined using correlation analysis results relationships moderate strength autonomic pain measures found change post exercise minus pre exercise score pain severity correlated change diastolic blood pressure healthy group cfs group positive correlations changes pain severity low frequency changes bodily pain diastolic blood pressure seen addition chfs change headache severity inversely correlated change high frequency heart rate variability limitations based cross sectional design study firm conclusions drawn causality relations conclusions reduced parasympathetic reactivation recovery exercise associated dysfunctional exercise induced analgesia cfs poor recovery diastolic blood pressure response exercise blood pressure remaining elevated associated reductions pain following exercise cfs suggesting role arterial baroreceptors explaining dysfunctional exercise induced analgesia cfs patients
smart grid power supply shift tree structure centralized power plants structure various kinds distributed energy resources based renewable energy batteries deregulation electricity market yield truly competitive market anyone become power seller buyer necessitate real time multiseller multibuyer power trading system however difficult realize system without centralized control additional trade complexity created large number sellers including ordinary homes paper authors propose novel distributed power cooperation algorithm maximizes home welfare based local information proposed algorithm enables home calculate electricity market price local household information trade maximize members satisfaction smart grid balancing consumption supply authors formulate distributed optimization problem logically prove authors algorithm obtain optimal user welfare global optimal approach within much shorter time american society civil engineers
paper presents approach electrical circuits using hilbert transform applying hilbert transform linear circuit equations sinusoidal form phase shifting occurs method extended complex form circuits analysis applications refer strictly sampled signals discrete signals input signal signal harmonic form application determines analysis two rlc circuits series respectively series parallel powered constant sinusoidal current developed
generating dimensional ghz state basis measuring basis dynamic quantum secret sharing scheme proposed proposed scheme multiple participants added deleted one update period shared secret need changed participants added deleted dealer need online compared existing schemes proposed scheme efficient practical
impact optical environment result shading panels becomes concerned paper describes calculate illumination level land around tracking isolated arrayed panel land flat plate dark shading influence tracking significant typically half average shadow tracking panel moves shading influence decreased increase pedestal height advantage tracking combined agriculture double use land elsevier ltd rights reserved
paper presents new extension salbp called assembly line resource assignment balancing problem type alrabp two main differences existing literature revealed work first objective function multiple one aimed minimize cycle time cost per time unit hour line fixed number stations satisfy constraints precedence tasks compatibility resources second difference lies proposed method solve problem new version multi objective genetic algorithm moga called hybrid moga hmoga elaborated full experiment design used obtain better moga parameters combination effectiveness hmoga assessed set literature problems performance hmoga shows good quality fronts generated better problem solving capacity two optimisations
paper argue flexible algorithm frameworks useful capture wide variety algorithmic components heuristic algorithms serve basic experimental frameworks one utilities implement wide variety different algorithm components alternative choices single stochastic local search methods currently extending existing frameworks direction exemplify approach considering example simulated annealing fact wide variety design choices algorithms proposed literature algorithm frameworks may simply collect potentially available choices provide tool experimental analysis specific algorithms component choices iii allow generation new algorithm variants combining exisiting components new ways show limited computational experiments show benefit tuning context way conclusions performance algorithms altered way
purpose review recent outbreak ebola virus disease evd led many discoveries regarding ebola although neurological symptoms evd previously described many reports since outbreak made clear evd lead neurological issues article review various neurological manifestations evd recent findings recently many neurological symptoms described acute evd including altered mental status seizures meningoencephalitis among others survivors evd also may develop neurological sequelae persistent headache memory loss exhibit abnormalities neurological exam additionally evident rare cases survivors may experience relapses evd months recovery including central nervous system cns summary evd result many clinical neurological manifestations acutely recovery research ongoing clarify nature ebola cns
uterine carcinosarcoma rare aggressive biphasic tumor comprises carcinomatous sarcomatous components mitosis associated factors thought discriminate two lesions aurora kinases mitotic enzymes highly expressed uterine malignancies identify clinical significance aurora kinase expression performed immunohistochemistry tissue microarrays using cores selected areas typical carcinomatous sarcomatous characteristics total samples included patients seoul national university hospital diagnosed uterine carcinosarcoma undergone staging operation patients clinical pathological data analyzed expression patterns aurora kinases investigated aurora kinases dominantly expressed cytoplasm phospho aurora kinases expressed nuclei phospho aurora kinase aurora kinase showed significantly higher expression carcinomatous component high expression phospho aurora kinase associated lymphatic metastasis positive pelvic lymph node omental involvement overexpression aurora kinase related vascular invasion high expression phospho aurora kinase aurora kinase prognostic factor progression free survival uterine carcinosarcoma conclusion expression aurora kinases associated bidirectional tumor dissemination lymphatic hematogenous pathways addition high expression phospho aurora kinase aurora kinase predictor progression free survival therefore inhibitors aurora kinases might prospective therapeutic options uterine carcinosarcoma
development effective monitoring systems power exchange fluctuations proportional alignment loading gas diesel generator units requires carrying detailed researches fluctuations exchange fluctuations case parallel work several units carrying researches real objects limited considerable cost given final stage therefore important developers adequate models studied objects researches output voltage frequency fluctuations real objects executed authors showed general casual character fluctuations range loadings represent non stationary casual process changing population mean dispersion authors developed mathematical model regulator stabilizing exchange fluctuations power studied system question hardware realization requires solving problem identification structure system line monitoring changes parameters signals authors proposed candidate solution problem example identification synthesis system measuring system performance indicators required appraise electric power quality system consequence performance quality
objective current study examined whether attention deficit hyperactivity disorder adhd symptoms associated dysregulation stress related mechanisms whether adhd symptoms interact affective disorders association dysregulated stress related mechanisms methods data obtained subjects participating netherlands study depression anxiety stress related mechanisms reflected following biomarkers hypothalamic pituitary adrenal axis indicators salivary cortisol awakening curve evening cortisol cortisol suppression dexamethasone suppression test dst autonomic nervous system measures heart rate pre ejection period respiratory sinus arrhythmia inflammatory markers reactive protein interleukin tumor necrosis factor alpha brain derived neurotrophic factor adhd symptoms measured using conners adult adhd rating scale used dichotomous high adhd symptoms yes continuous inattentive symptoms hyperactive impulsive symptoms adhd index results regression analyses showed associations high adhd symptoms inattentive symptoms adhd index higher cortisol awakening curve hyperactive impulsive symptoms less cortisol suppression dst inattentive symptoms longer pre ejection period however associations cortisol awakening curve disappeared adjustment depressive anxiety disorders associations observed adhd symptoms inflammatory markers bdnf adhd symptoms interact affective disorders dysregulation stress related mechanisms conclusion associations observed adhd symptoms hpa axis pre ejection period mostly driven depressive anxiety disorders study found evidence adhd symptomatology associated dysregulations inflammatory markers bdnf consequently adhd symptoms confer added risk disturbances stress related mechanisms already risk population affective disorders elsevier ltd rights reserved
although high rates serum testosterone deficiency reported men spinal cord injury sci determinants attributes yet established aim study recognize among putative determinants attributes androgen deficiency significantly associated low testosterone adjustment confounders recognizable men chronic sci biochemical androgen deficiency total testosterone exhibited patients significant correlates testosterone levels follows weekly leisure time physical activity ltpa explored ltpa questionnaire people sci body mass index bmi homeostatic model assessment insulin resistance homa triglycerides sexual symptoms explored aging males symptom ams questionnaire multiple linear regression analysis among putative determinants low testosterone weekly ltpa bmi exhibited significant association testosterone levels explaining testosterone variability respectively linear regression models among various putative attributes androgen deficiency lower sexual desire lesser extent higher homa exhibited significant associations lower testosterone levels adjustment bmi age comorbidities weekly ltpa conclusion poor ltpa high bmi low sexual desire independent predictors low testosterone men chronic sci relevant clinical practice features routinely assessed rehabilitation settings sci poor ltpa high bmi modifiable life style related risk factors prospective studies could clarify whether life style modification could increase level testosterone improve low sexual desire relevant clinical attribute low testosterone men sci
although small hydropower projects shps encouraged sources clean green energy paucity research examining socio ecological impacts assessed perceived socio ecological impacts shps within western ghats india conducting semi structured interviews local respondents primary interview data sequentially validated secondary data respondent perceptions subsequently compared expected baseline assured impacts evaluated level awareness shps perceived socio economic impacts influence resource access impacts human elephant interactions general level awareness shps low assurances local electricity employment generation remained largely unfulfilled additionally respondents faced numerous unanticipated adverse impacts found strong relationship shp construction increasing levels human elephant conflict based disparity assured actual social impacts suggest policies regarding shps suitably revised
posterior superior temporal suclus psts represents central hub complex cerebral network person perception emotion recognition also suggested heavy connections face body specific cortical fusiform face area ffa extrastriate body area eba subcortical structures amygdala information whether psts causatively involved sustaining conscious visual perception emotions expressed faces bodies lacking explored issue combining binocular rivalry procedure emotional neutral face body postures rivaled house images line repetitive transcranial magnetic stimulation rtms found temporary inhibition right psts reduced perceptual dominance fearful faces increased perceptual dominance fearful bodies leaving unaffected perception neutral face body images inhibition vertex effect conscious visual perception neutral emotional face body stimuli thus right psts plays causal role shortening conscious vision fearful faces prolonging conscious vision fearful bodies results suggest psts selectively modulates activity segregated networks involved conscious visual perception emotional faces bodies speculate opposite role right psts conscious perception fearful face body maybe explained different connections region entertains face body selective visual areas well amygdalae premotor regions elsevier ltd rights reserved
amid growing calls greater collaboration journalism computer programming article examines salient case study reveals processes communication exchange work production intersection social occupational worlds focus key stage knight mozilla news technology partnership namely online learning lab individuals sought coordinate around shared interest innovation journalism open source software drawing science technology studies concepts trading zones boundary objects explore distinct understandings news technology converged diverged ultimately blended around three thematic ambitions making news process oriented participatory socially curated window onto boundary negotiations journalism provides glimpse future development news norms values programmers ethics assume greater role journalistic field heart leading institutions
sustainability issues often difficult companies manage require communication across organisational departments divisions paper provides first empirical evidence communication silos exist within mining sector may impeding effective water management results social network analysis mining company revealed gaps direct communication water related issues two largest production departments gap particularly surprising departments connected communication networks studied namely information ideas problem solving friendship health safety environment department played crucial brokerage role within water network suggesting water primarily perceived environmental issue lack direct communication major production departments could pose barrier recognising responding production critical water risks work also found water network characteristic core periphery structure communication vulnerable removal central hubs hubs dominated senior management may present risk responding promptly water related crises research needed investigate impacts siloed communication structure managing sustainability issues including energy community development elsevier ltd rights reserved
purpose study propose novel differential protection scheme converters current differential relay widely used protect transformers generators busbars transmission lines however applied inverter used transmission line system paper presents novel differential protection scheme converters using tellegen theorem tellegen theorem simple theorem electric power proved kirchhoff current law kirchhoff voltage law theorem define three kinds electric power power flow proposed technique evaluated using simulation studies based ideal inverter circuit transforms test results show validity proposed protection
article presents novel hybrid optimization approach nonlinear controller distribution static compensator dstatcom dstatcom connected distribution system distributed generation units nonlinear control based partial feedback linearization two proportional integral derivative pid controllers regulate voltage track output control system conventional scheme trial error method used determine pid controller coefficients article uses combination fuzzy system simulated annealing intelligent water drops iwd algorithms optimize parameters controllers obtained results reveal response optimized controlled system effectively improved finding high quality solution results confirm using tuning method based fuzzy iwd significantly decrease settling rising times maximum overshoot steady state error voltage step response dstatcom proposed hybrid tuning method partial feedback linearizing pfl controller achieved better regulation direct current voltage capacitor within dstatcom furthermore event fault proposed controller tuned fuzzy iwd method showed better performance conventional controller pfl controller without optimization fuzzy iwd method regard fault duration clearing times
paper interested exploring performance potential raw disk reduce disk overhead web proxy sever without interaction conventional file system show superior performance potential raw disk approach design simple block structured storage management system bsms based previous studies experimental evaluations using web polygraph suggest raw disk another solution improve disk performance web proxy servers
relaxation oscillator kind oscillator based behavior physical system return equilibrium disturbed relaxation oscillation equation primary equation relaxation oscillation processes relaxation oscillation equation fractional differential equation initial conditions paper approximate solutions relaxation oscillation equation obtained developing wavelet collocation method fractional differential equations using cubic spline wavelet analytical expressions fractional derivatives caputo sense cubic spline functions presented main advantage proposed method transforms problems system algebraic equations suitable computer programming reliability efficiency proposed method demonstrated numerical examples
opinion dynamics investigates fusion process opinion formation group agents powerful tool supporting management public opinions however real life situations firms administrations interested formation public opinions also hope influence guide forming opinions reach either consensus even specific consensus point paper aims developing consensus building process opinion dynamics based concept leadership analyzing structure social network agents form consensus proposed strategy adding minimum number interactions social network form consensus based leadership afterwards generalized consensus strategy deal consensus problem established target eventually detailed theoretical proofs numerical analysis provided demonstrate feasibility effectiveness consensus strategy elsevier inc rights reserved
design construction working prototype device measure magnetic field induced conducting wire well current induces field based magneto optical faraday effect described work transducer element nanocomposite material made maghemite nanoparticles embedded porous silica matrix high low field verdet constant figure merit relating faraday specific rotation absorption coefficient device mostly developed low cost parts using open source prototyping platform arduino plus compact commercial lock amplifier shown sensing material shows linear response would allow measuring currents similar wire setup allows avoiding use magnetic field concentrator elsevier rights reserved
high resolution drought forecast model ungauged areas developed study standardized precipitation index spi standardized precipitation evapotranspiration index spei month time scales forecasted month lead times degrees resolution use long range climate forecast data compared use climatological data periods observation data machine learning models utilizing drought related variables based remote sensing data compared spatial interpolation kriging two performance measures used one producer drought accuracy defined number correctly classified samples extreme severe moderate drought classes total number samples classes user drought accuracy defined number correctly classified samples drought classes total number samples classified classes one machine learning models extremely randomized trees performed best cases terms producer accuracy reaching spatial interpolation performed better terms user accuracy contribution long range climate forecast data significant conditions used study improvement expected forecast skill improved sophisticated downscaling method used simulated decreases forecast error precipitation mean temperature tested simulated decrease forecast error precipitation improves drought forecast decrease forecast error mean temperature contribute much although still room improvement developed model used drought related decision making ungauged areas elsevier rights reserved
background ozone ubiquitous air pollutant increasing concentrations many populous regions toxicological studies show ozone cause oxidative stress increase insulin resistance pathways may contribute metabolic changes diabetes formation paper investigate association ozone incident type diabetes large cohort african american women methods used cox proportional hazards models calculate hazard ratios hrs incident type diabetes associated exposure ozone cohort african american women living metropolitan areas across united states ozone levels estimated using epa models community multiscale air quality cmaq predictions fused ground measurements resolution years results per interquartile range increment ppb ozone incident diabetes adjusted models association unaltered models controlled fine particulate matter diameter associations modified nitrogen dioxide levels hrs ozone levels larger areas lower conclusions results provide initial evidence positive association incident diabetes african american women given ubiquity ozone exposure importance diabetes quality life survival results may important implications protection public health elsevier ltd rights reserved
aim study assess impact cryotherapy changes surface body temperate efficiency thermoregulatory processes relation intensity cryogenic stimuli study included football players students intervention groups divided three subgroups treated cryostimulation degrees body surface temperature measured baseline cryostimulation min treatment regions trunk lower limbs upper limbs examined difference baseline raw curves raw curves performed directly min cryotherapy three levels temperature studied groups baseline surface body temperature lower athletes student decrease surface temperature observed cryotherapy significant greater football players students drop surface temperature athletes degrees regions upper limbs trunk degrees lower limbs degrees reported min restitution surface temperature restored baseline subjects examined regions greater dynamics athletes study results indicate better effectiveness thermoregulatory processes football players group greatest changes temperature occurred cryostimulation temperature degrees research required assess recommended values thermal stimuli
cognitive affective psychosocial factors found underlie adherence preventive behaviors women risk developing lymphedema following treatment breast cancer aim study determine factors associated adherence self management behaviors women diagnosed breast cancer related lymphedema bcrl women bcrl recruited community based breast cancer organization three australian lymphedema treatment clinics participants completed online questionnaire assessing demographics medical history adherence self management behaviors psychosocial variables personal control treatment control consequences distress self regulation affect knowledge lymphedema self management total women participated study participants reported adhering mean five seven behaviors participants adhering seven behaviors adherence individual behaviors ranged self lymphatic drainage skin care greater knowledge lymphedema significantly correlated higher adherence hierarchical multiple linear regression analysis indicated medical history factors time since diagnosis undergone hormone replacement therapy predicted significant amount variance adherence findings highlight importance patient knowledge optimal adherence self management regimen addition medical history factors may identify patient risk nonadherence lack association adherence psychosocial factors considered study indicates factors underlying adherence affected women differ considerably factors prompting preventive behavior adherence risk population
recently linear synchronous generator exploitation sea wave energy proposed solution require reactive power magnetize needs permanent magnets assure excitation electrical energy generated device must converted conditioned order match instantaneous utility requirements power link sea interconnection needed paper order overcome difficulty authors propose use electrical energy generated generate situ hydrogen result output generation would hydrogen stored used needed proposed electrical generator linear synchronous generator
paper studies existence synergisms degradation agents geotextiles purpose polypropylene geotextile stabilised chimassorb exposed degradation tests immersion liquids water sulphuric nitric acids sodium hydroxide metallic ion solutions thermo oxidation artificial weathering geotextile exposed individually degradation agent single exposure exposed successively combinations two agents multiple exposures results showed cases combined action two degradation agents damaging sum individual effects agent relevant examples included immersion sodium hydroxide thermo oxidation immersion iron nitrate thermo oxidation immersion cadmium copper nitrate artificial weathering elsevier ltd rights reserved
across reproductive spectrum obesity associated greater risks adverse health outcomes including higher rates infertility subfertility early pregnancy loss fetal deaths stillbirths congenital anomalies pregnancy complications excess reproductive morbidity associated obesity may increase longer duration making current trends among children young adults particularly critical terms future reproductive potential obese women lower chance pregnancy following vitro fertilization ivf require higher dosages gonadotropins reduced rates implantation clinical intrauterine gestation live birth rates increased rates pregnancy loss well greater risks prematurity preeclampsia even stratified plurality racial ethnic differences overweight obesity ivf outcomes reported compared normal weight women failure achieve clinical intrauterine gestation significantly likely among obese women overall normal weight obese asian women normal weight hispanic women overweight obese black women among women conceive compared normal weight women failure achieve live birth significantly likely among overweight obese women overall among overweight obese asian women overweight obese hispanic women normal weight obese black women although weight loss theoretically first line therapy obese women lifestyle factors regular physical exercise elimination tobacco use alcohol consumption stress management may immediate benefit achieving conception american society reproductive medicine
paper proposes positive temperature coefficient ptc self heating method evs operated independently external power source low temperature lithium ion battery lib pack discharging electricity provide ptc material power three comparative heating experiments carried respectively charge discharge tests implemented results demonstrate superiority self heating method proving discharge capability especially discharge capacity self heated pack better external power heated pack order evaluate heating effect method studies conducted temperature distribution uniformity heated pack firstly geometric model established heat generation rate ptc materials lib calculated thermal characteristics self heating experiment processes numerically simulated validating accuracy modeling confirming temperature distributions inside pack heating kept good uniformity therefore ptc self heating method verified significant effect improvement performance lib low temperature
optimization model developed maximize net power output bottoming organic rankine cycle orc ten working fluids exhaust heat recovery internal combustion engine ice theoretically ice orc system influenced several unsteady parameters make difficult determine optimal design parameters therefore introduce probability density functions order investigate impacts ice power output sink temperature pinch point temperature difference orc performances unsteady parameter illustrated analyze performances ice orc system furthermore monte carlo simulation introduced investigate role played unsteady parameters obeys different probability distributions methods obtained convergence values frequency distributions cumulative probability distributions various performance parameters results provide valuable suggestions design ice orc system elsevier ltd rights reserved
background synovitis inflammation related disease linked rheumatoid arthritis osteoarthritis infections trauma inflammation accompanied immune cells infiltration initiates inflammatory response causing pain discomfort affecting normal joint function treatment synovitis based administration anti inflammatory drugs biological agents platelet rich plasma mesenchymal stem cells however evaluation validation effective therapies synovitis requires establishment clinically relevant animal models results study large white pigs pre immunized evaluate antigen induced synovitis immune monitoring synovial fluids model allowed identification cell subsets immune biomarkers moreover evolution synovitis performed arthroscopic procedures kinetic analysis summary paper describes animal model antigen induced synovitis used evaluation anti inflammatory therapies conclusions novelty paper lies development clinically relevant model synovitis permits simultaneous evaluation synovitis immunological surgical kinetic point view
existing works wiener system identification essentially focused case output nonlinearity memoryless memory nonlinearities considered focus restricted backlash like nonlinearities paper considering wiener systems output nonlinearity general hysteresis operator captured well known bouc wen model wiener system identification problem addressed making use steady state property obtained periodic regime referred hysteretic loop assumption complexity problem comes system nonlinearity well unknown parameters enter non affine way model shown linear part system accurately identified using frequency method nonlinear hysteretic subsystem identified basis parameterized representation using prediction error approach copyright john wiley sons ltd
gas liquid gtl products synthetic hydrocarbons produced natural gas using fischer tropsch process process yields synthetic crude oil consists saturated hydrocarbons primarily linear alkanes increasing amounts branched methyl groups alkanes chains get longer addition small amounts cycloalkanes branched cyclopentanes cyclohexanes may formed polymerization reaction prolongs synthetic crude subsequently refined range products similar petroleum refining however contrast petroleum derived analogs gtl products essentially free unsaturated aromatic constituents also sulfur oxygen nitrogen containing constituents present regulatory perspective gtl products new substances require extensive testing assess hazardous properties consequence wide range gtl products covering entire portfolio gtl products tested past years wide variety toxicological studies including reproductive prenatal development toxicity studies review provides overview hazardous properties various gtl products general data collected gtl products provide strong proof exert minimal health effects addition data provide supporting evidence known mechanisms mammalian toxicology petroleum derived analogs cases adverse effects found gtl substances usually less severe adverse effects observed petroleum derived analogs
nonlinear problems drawn great interest extensive attention engineers physicists mathematicians many scientists real systems inherently nonlinear nature model analyze nonlinear systems many mathematical theories methods developed including volterra series paper basic definition volterra series recapitulated together frequency domain concepts derived volterra series including general frequency response function gfrf nonlinear output frequency response function nofrf output frequency response function ofrf associated frequency response function afrf relationship volterra series nonlinear system models nonlinear problem solving methods discussed including taylor series wiener series narmax model hammerstein model wiener model wiener hammerstein model harmonic balance method perturbation method adomian decomposition challenging problems state arts series convergence study kernel identification study comprehensively introduced addition detailed review given applications volterra series mechanical engineering aeroelasticity problem control engineering electronic electrical engineering
work addresses model predictive controller design complex solar boreal thermal storage system models real drake landing solar commercial community overall discrete system obtained coupled finite infinite dimensional subsystems solar collector heat exchanger hot tank gas boilers without spatial approximation model reduction novel model predictive control addresses house heat regulation constrained optimization problem manipulation constraints accounts possible unstable system dynamics disturbances arising solar geothermal radiations realistic output regulation considered inclusion observer constructs finite infinite dimensional states proposed model development control regulation successfully account long range variability environmental economic conditions associated overall operational costs large scale solar energy community finally controller performance assessed numerical simulations elsevier ltd rights reserved
process tension control material testing using flexible circuit board testing machine fcbtm featured multi variable nonlinearity time delays time variation order ensure tension precision stability servo motor speed reliability test results paper establishes accurate system model fcbtm novel three dimensional adaptive fuzzy pid controller designed specially simulation results show proposed adaptive fuzzy control method robust external disturbance also excellent dynamic steady state characteristics traditional ones
qualities color images captured digital imaging devices vulnerable scene illumination settings given environment colors captured objects may accurately reproduced illumination settings uncontrollable known priori undesirable property inevitably degrade qualities captured images lead difficulties subsequent image processing stages considering task controlling scene illumination nontrivial color correction emerged plausible post processing procedure efficiently restore scene chromatics given image study new color correction technique called saturation avoidance color correction sacc algorithm proposed remove undesirable effect scene illuminants unlike well established color correction algorithms proposed sacc comprises nonlinear pixel adjustment mechanism avoid saturation effect color manipulation process collection color images including indoor outdoor underwater images used verify capability sacc extensive experimental studies reveal proposed algorithm preferable existing techniques former high capability mitigate color saturation issue able produce corrected images pleasant visualization
traditional hapten protein conjugate nicotine vaccines shown less desired immunological efficacy due poor recognition internalization immune cells developed novel lipid polymeric hybrid nanoparticle based nicotine vaccine enhance immunogenicity conjugate vaccine studied influence particle size immunogenicity pharmacokinetic efficacy results demonstrated nanovaccines regardless size could induce significantly stronger immune response nicotine compared conjugate vaccine particularly significantly higher anti nicotine antibody titer achieved compared nanovaccine addition nanovaccines reduced distribution nicotine brain significantly nanovaccine exhibited better pharmacokinetic efficacy nanovaccine presence alum adjuvant results suggest lipid polymeric nanoparticle based nicotine vaccine promising candidate treat nicotine dependence elsevier inc rights reserved
melatonin pineal gland secretory product implicated pathophysiology migraine melatonin critical functions human physiology research underscores importance melatonin circadian rhythm sleep mood regulation clinical observations indicated migraine attacks seasonal menstrual circadian timing suggesting chronobiological mechanisms alterations may causally involve etiology disease however topic received relatively little attention migraine literature associations melatonin circadian preference sleep mood states investigated current study fifty five patients females males compared gender age matched control subjects females males socio demographical questionnaire beck depression inventory beck anxiety inventory bai pittsburgh sleep quality index psqi profile mood states poms morningness eveningness questionnaire administered volunteers blood samples taken participants unlit room hamper melatonin secretion blood melatonin levels measured using quantitative elisa test comparison controls melatonin levels significantly lower among migraine patients migraineurs reported significantly greater scores bai confusion bewilderment subscale poms total sleep latency subscale psqi migraine patients nausea migraine attacks reported bouts relevant certain food consumption cheese chocolate significantly lower levels melatonin contrarily groups reveal statistically substantial difference circadian preferences
assistive technologies application area several artificial intelligence techniques tools successfully applied support elderly impeded people daily activities however approaches tend center user tool interaction neglecting user connection social environment caretakers relatives health professionals possibility monitor undesired behaviour providing adaptation dynamic environment early response potentially dangerous situations previous work presented coaalas intelligent social norm aware device elderly people able autonomously organize reorganize interact different actors involved elderly care either human actors devices paper put work context first examining desirable properties system analysing state art relevant topics verifying validity proposal larger context call avicena avicena aim develop semi autonomous collaborative tool promote monitored intensive extended personalized therapeutic regime adherence home based adaptation techniques
due marked heterogeneity clinical presentations comprehensive knowledge angioedema phenotypes crucial correct diagnosis choosing appropriate therapeutic approach one ways meaningful clinical distinction made forms angioedema occurring without wheals angioedema wheals rash hallmark urticaria either acute chronic spontaneous inducible angioedema without wheals may still manifested patients urticaria may also occur separate entity several classifications angioedema part urticaria published time latest one released hawk group consensus see provided classification forms angioedema without wheals distinct urticaria focus present review time hawk consensus classification best terms covering pathophysiology mediators involved angioedema triggers clinical expression according classification three types hereditary angioedema genetic inh deficiency normal inh factor xii mutations unknown origin four types acquired angioedema inh deficiency related ace inhibitors intake idiopathic histaminergic idiopathic non histaminergic presented review distinctive clinical features phenotype details
autonomous unmanned aerial vehicles uavs often carry video cameras part payload outdoor video captured cameras used estimate attitude altitude uav detecting location horizon video frames paper presents video frame processing algorithm estimating pitch roll uav well altitude frames obtained downward pointing video camera equipped fisheye lens open loop estimates serve redundant data used implement graceful degradation event main closed loop control sensors fail fault tolerance purposes augment inertial sensors increased accuracy estimated values mean error angular degrees roll angular degrees pitch altitude estimation video mean error meters results presented compared actual attitude altitude values obtained traditional inertial measurement unit case altitude comparison absolute air pressure sensor algorithm developed personal computer work frames per second uses simple image processing functions deployed using open source libraries lightweight computing boards capable image processing
construction project management increase project cost due resource fluctuation widespread paper proposed new resource leveling control indicators reflecting resources idle resources mobilizing according disadvantages traditional control indicators resource leveling project network planning considering substantial increased costs due resources fluctuation based classification extra costs study found relationship resource imbalance extra costs analyzed resources idle resources mobilizing cost variation caused resource imbalance thus control indicators resources resources mobilizing reflecting resource leveling proposed addition based case study feasibility control indicators proposed paper resource leveling project network planning validated information valuable practical application resource leveling optimization engineering project management
double absorption heat transformer daht promising device reducing use fossil fuels since utilize renewable sources waste heat provide high temperature energy absorber evaporator important component daht system exists optimum absorber evaporator temperature oaet maximum coefficient performance cop exergy efficiency ecop obtained simultaneously paper optimization study carried means parametric analysis using mathematical model developed software engineering equation solver effects operating parameters absorber condenser evaporator generator temperatures design parameters including first second economizer efficiencies oaet corresponding maximum cop ecop analyzed detail besides suggestions derived results also given elsevier ltd rights reserved
work represents first attempt study effects financial constraints firm growth within business services argued firms different terms size also way operate specific industry thus firms either characterized use intensive professional knowledge alternatively use workforce specific professional skills business services included results reveal relative importance internal sources financing respect external ones liquidity constraints mainly affect growth industries requiring qualified labor pool computer programming information service activities well professional scientific ones sectors foremost operate small firms superior innovation capacity therefore considered risky face difficulties raising debt capital favorable terms
study investigated whether orthorexia nervosa characterized obsessive fixation eating healthy may predicted demographics variables gender bmi personality variables self esteem narcissism perfectionism participants college students completed several online questionnaires assessed variables principal components analysis confirmed eating habits questionnaire gleaves graham ambwani assesses three internally consistent components healthy eating behaviors problems resulting behaviors positive feelings associated behaviors manova tests subjects effects revealed significant interactions gender bmi men women higher bmi associated greater symptomatology components partial correlation analyses controlling gender bmi revealed narcissism perfectionism positively correlated aspects symptomatology elsevier ltd rights reserved
background evidence systemic treatments severe childhood eczema limited largely based extrapolation data adult studies current therapies often immunosuppressant may associated short long term side effects increasing vitro murine model evidence role ige immunopathogenesis atopic eczema aim study assess whether anti ige treatment omalizumab improves eczema compared placebo methods design atopic dermatitis anti ige paediatric trial adapt randomised double blind placebo controlled study assessing role anti ige management severe paediatric eczema children severe atopic eczema objective scoring atopic dermatitis scorad score recruited children candidates systemic therapy failed systemic therapy experienced side effects systemic therapy sixty two patients aged years receive anti ige months primary outcome measure validated eczema score objective scorad weeks study power detect relative reduction scorad active placebo groups significance discussion ige may role play eczema particularly childhood forms basis hypothesis anti ige may effective treatment patient population largest study evaluate efficacy anti ige omalizumab versus placebo children severe eczema findings help clarify role anti ige potential treatment option patients severe childhood eczema
paper hybrid population based metaheuristic search algorithm named gravitational search algorithm gsa combined particle swarm optimization pso gsa pso proposed optimal designs two commonly used analog circuits namely complementary metal oxide semiconductor cmos differential amplifier circuit current mirror load cmos two stage operational amplifier circuit pso gsa simple population based robust evolutionary algorithms problem suboptimality individually proposed gsa pso based approach overcome disadvantage faced pso gsa algorithms employed paper optimal designs two amplifier circuits transistors sizes optimized using gsa pso order minimize areas occupied circuits improve design performance parameters circuits various design specifications performance parameters optimized optimize transistor sizes design parameters using gsa pso using optimal transistor sizes simulation program integrated circuit emphasis simulation carried order show performance parameters simulation results justify superiority gsa pso differential evolution harmony search artificial bee colony pso terms convergence speed design specifications performance parameters optimal design analog cmos amplifier circuits shown gsa pso based design technique amplifier circuit yields least mos area designed circuit shown best performance parameters like gain power dissipation etc compared recently reported literature still difficulties challenges faced work proper tuning control parameters algorithms gsa pso conflicting design performance parameters design specifications partially overcome repeated manual tuning multiobjective optimization may proper alternative way overcome difficulties
paper discuss development ambient intelligent based system monitoring dementia patients living homes within system groups unobtrusive wireless sensor devices deployed specific locations within patient home accessed via standardized interfaces provided open middleware platform sensor group intelligent agents used learn fuzzy rules model patient habitual behaviours environment online rule adaptation technique applied facilitate short term tuning learnt behaviours long term tracking behaviour changes could due effects cognitive decline caused dementia proposed system reports macro level behaviour changes micro level perception drift care providers enable make better informed assessments patient cognitive abilities changing care needs demonstrate experiments real pervasive computing environment intelligent agent approach learn model user behaviours allow online adaptation model better approximate learnt behaviours identify long term macro level behaviour changes could attributed cognitive decline also show example user perceptions thermal comfort may captured visualised provide means micro level perception changes monitored
paper reports new approach towards construction multifunctional periodic mesoporous organosilica pmo integrates range advantages mesoporous structural order selective nucleobase recognition properties stimuli responsive site specific delivery anticancer agents cancer tissues adsorption single entity first appropriate organic functional receptor precursor synthesized chemical process used fabricate multifunctional pyridine containing pmo material dmpy pmo hydrolysis condensation route designed organic inorganic hybrid mesoporous silica chemosensor showed intrinsic selective recognition nucleobase specifically thymidine multipoint hydrogen bonding interactions suitably arrayed receptor sites loaded rigid silica framework vitro cytotoxicity test showed designed chemosensor materials good biocompatibility therefore could promising candidates delivery range therapeutic agents confocal laser scanning microscopy clsm confirmed material internalized effectively cancer cells mcf cells addition dmpy pmos showed efficient ion removal capacity significantly high levels adsorption mmolg results suggest prepared multifunctional pmo hybrid potential use smart material range applications biomolecule recognition biomedical applications efficient adsorbent removal metal ions
gastric lymphoma rare accounting gastric neoplasms lymphomas treatment stratified based histologic type stage helicobacterpylori infection translocation status surgery longer mainstay treatment reserved rare situations perforation fistula formation severe bleeding multimodal treatment including pylori eradication radiation therapy chemotherapy immunotherapy provided appropriate result excellent outcomes
erectile dysfunction low testosterone levels common men type diabetes investigated impact testosterone quality life qol diabetic men men identified within study cohort men subjects completed health androgen deficiency aging male questionnaires total tesosterone bioavailable testosterone sex hormone binding globulin levels study participants measured free testosterone levels calculated cft subgroup patients completed international index erectile function iief questionnaire linear regression analyses corrected age body mass index bmi glycosylated haemoglobin hba smoking alcohol consumption cardiovascular disease cvd total scores significantly positively correlated levels levels cft levels among men trends strengthened adjusting age bmi hba smoking alcohol consumption cvd ttr btr cftr iief scores significantly correlated inversely cft levels positive linear relationship observed iief scores total score patients reported average score less without lower testosterone greater severity independently correlated poorer physical function social function vitality decline general health domains first study report testosterone deficiency severity independently associated reduced qol men furthermore low testosterone markers poor health impact individual self perception health status
paper proposes novel compressive sensing based perceptual hashing algorithm visual tracking tracking object represented dimensionality reduced feature projected perceptual hashing feature sparse measurement matrix besides updating weight map assigned object weight map updated according accumulation foreground block distance foreground block center weight map based object representation weight map tracker searches local region maximum similarity coarse fine way addition introduce visual attention knowledge object namely foreground always located center weight map handle model drift problem extensive experiments demonstrate proposed tracking method outperforms state art methods challenging scenarios tracker especially insensitive location initial box elsevier rights reserved
selective targeting tumor site chemotherapeutic agents appears one effective methods address many problems encountered conventional chemotherapy work poly oligoethylene glycol methacrylate poegma based bone targeting polymers bearing antiangiogenic drug combretastatin synthesized using free radical polymerization targeted nontargeting copolymers evaluated bone targeting efficiency cytotoxicities endothelial cells namely huvecs saos cancerous cell lines well antiangiogenic activity endothelial cell tube formation huvecs observed drug conjugated polymers conjugated bisphosphonate groups containing drug alendronate aln remarkably high affinity bone mineral compared polymerdrug conjugates devoid bisphosphonate groups targeted nontargeted polymerdrug conjugates show sustained drug release rat plasma overall release days vitro studies revealed high levels cytotoxicity polymerdrug conjugates huvecs moderate cytotoxicity toward saos importantly conjugated copolymers displayed excellent level antiangiogenic activity deduced vitro endothelial cell tube formation assay using huvecs overall novel bone targeting antiangiogenic polymerdrug conjugate elaborated carry additional anticancer drugs disclosed
anusat micro satellite developed anna university overall guidance isro intended provide digital communication facilities number universities colleges amature satellite radio operators thermal design satellite poses several challenges mainly lower thermal inertia power generation paper briefs thermal design anusat uses passive thermal control system thermal heaters provided limited power generation thermal design predicted temperatures expected well within thermal operating limits orbit data anusat confirms judicious selection effectiveness thermal control system
high number circulating cells advocated distinguish primary myelofibrosis philadelphia negative myeloproliferative neoplasms reevaluated diagnostic interest measuring circulating cells healthy volunteers consecutive patients diagnosis myeloproliferative neoplasm suspected roc curve analysis showed number excludes diagnosis primary myelofibrosis sensitivity specificity area curve patients pmf harboring calr mutation circulating cells patients either jak mpl mutation respectively results suggest fast simple non invasive standardized test particular interest exclude diagnosis primary myelofibrosis
aim publication brief safe cost effective security solution cost time estimation tool small medium size enterprises since either budget cyber security miniscule general evaluation tool used determine approximate time costs small company might face implementing comprehensive security solution analyzing iso iec standards additional security guidelines several recommendations necessary creates security implementation evaluation tool resulting product tool allows member enterprise carry small test determine necessary resources time security implementation
examine pattern solutions generalized nonlocal logistic map includes spatial kernels growth competition terms show map includes particular case nonlocal fisher kolmogorov equation demonstrate existence three kinds stationary nonlinear solutions one uniform one cosine type refer wavelike solution another form gaussian also obtain analytical expressions describe nonlinear pattern behavior system establish stability criterion define thermodynamics quantities entropy order parameter based pattern pattern pattern pattern transitions properly analyzed show pattern solutions may related recently observed peak adding phenomenon nonlinear optics elsevier rights reserved
structured observations parent child interactions commonly used research clinical settings require additional empirical support current study examined capacity child directed play parent directed play parent directed chore interaction analogs uniquely predict development conduct problems across year follow period parent child observations collected families high risk neighborhoods summer following child first grade year participating children female white black average age years first assessment conduct problems assessed via parent report teacher report five assessment points first grade seventh grade latent growth curve modeling used analyze predictors conduct problem trajectory across year follow period race sex socioeconomic status maternal depressive symptoms controlled parental negative attention child directed play predicted higher levels parent reported conduct problems concurrently year follow period parental negative attention child directed play also predicted higher teacher reported conduct problems years later findings support use child directed play parent directed chore analogs predicting longitudinal development conduct problems presence parental negative attention child directed play appears especially important predictor greater conduct problems time across multiple domains additionally potential importance task incongruent behavior proposed study
fast development high voltage hvdc cable cable insulation conditions got attention paper tests conducted study electrical tree initiation silicone rubber sir polarity reversal voltages found electrical tree initiation significant polarity effects polarity reversal voltages single branch like trees branch like trees polarity reversal voltages pre stressing effects polarity reversal pre stressing voltage positive effects electrical tree initiation pre stressing time little influence space charge distribution sir high electric field studied flat plate pulsed electro acoustic pea system characteristics discussed explain phenomenon moreover different treeing breakdown phenomenon found polarity reversal voltage differs voltage existence fast charges slow charges gives reasonable explanation special attention paid transient situation like polarity reversal would result irreversible effects easily affect true length life hvdc cables elsevier rights reserved
number plate recognition identifies vehicle number without human intervention computer vision application many important applications proposed system consists two parts number plate area extraction character identification paper morphological operation based approach presented number plate area extraction effective segmentation characters done plate area extraction histogram based character segmentation simple efficient technique used segmentation template matching approach used character extraction number plate variable character length poses limitation number identification earlier reported literature taken care using histogram based character segmentation method
cognitive aspects children executive function examined moderators effectiveness parental guidance children learning thirty two year old children parents observed joint problem solving forms guidance geared towards cognitive assistance coded directive elaborative children responses recorded children assessed independent version task parent rated composite working memory planning used measure directive guidance parents associated child errors joint activity whereas elaborative guidance associated better performance parent rated moderated relation relation elaborative guidance better performance significant children low independent task moderated relation parent guidance children performance children low worse parents provided directive guidance children high directive guidance associated better independent performance findings suggest extent children performance relates different forms parents guidance varies elaborative assistance may helpful children low copyright john wiley sons ltd
hyperprolactinemia underappreciated unknown adverse effects antipsychotics consequences hyperprolactinemia compromise therapeutic adherence serious present consensus recommendations made group experts regarding management antipsychoticinduced hyperprolactinemia current consensus developed phases review scientific literature subsequent round table discussion attempt reach consensus among experts review authors final conclusions reaching complete consensus include recommendations appropriate time act hyperprolactinemia detection discuss evidence available options decreasing dose antipsychotic drug switching antipsychotics adding aripiprazole adding dopaminergic agonists type treatment consensus also included recommendations specific populations patients first psychotic episode pediatric youth population bipolar disorder personality disorders elderly population elsevier inc rights reserved
hue chroma components image pixel carry crucial information exploited perform segmentation however due directional property circular distribution required characterize hue component article propose mixture variate circular linear distributions modelling hue chroma information proposed model incorporates joint distribution circular linear variable means circular copula offers flexible architecture deals heterogeneous margins different mixture components apply model psoriatic plaque segmentation skin images using hue chroma information observe chroma exhibits heterogeneous distribution skin image moreover joint distribution hue chroma possesses multi modal characteristics model suitable perform segmentation circumstances segmentation perform automatic plaque localization means statistical model exploits hue information segmented regions conduct experiments set psoriasis skin images segmentation localization performances evaluated respect number commonly used criteria experimental results show proposed segmentation model outperforms several competing supervised unsupervised methods detecting psoriatic plaque regions skin images
female outbred albino rats daily subjected forced inhalations peat smoke cores packed mixture peat wood pulp parts per thousand yen per combination oral afobazole anxiolytic days pregnancy exposure peat smoke inhibited body weight gain pregnant rats caused increase postimplantation deaths reduction fetal weights increase number hematomas hemorrhages fetuses afobazole doses reduced significantly untoward effects peat smoke fetal development
many digital control systems required perform computation strictly periodic fashion provide high control performance system designers need assign time slots infinitely repeated given strict period task time slots different tasks overlap previous work studied decide system schedulable certain time slot assignment still unexplored area select time slots strictly periodic tasks make schedulable paper propose efficient method solve problem method explores relations among task periods improve possibility finding feasible start time configurations finally conduct experiments randomly generated workload evaluate performance proposed method elsevier rights reserved
ciliated cells found epithelium oral cavity human embryos fetuses starting seventh week prenatal development early stages prenatal development week cells cilia cover dorsal surface tongue soft palate whereas found near gland ducts circumvallate foliate lingual papillae weeks development ultrastructure axoneme cilia corresponds structure motile cilia represented nine microtubule doublets surround central pair microtubule singlets immunohistochemical study performed weeks development identified nerve endings associated ciliated cells week development cytoplasm ciliated cells immunopositive nse spatial distribution ciliated cells tongue epithelium week development related morphogenesis lingual papillae role human oral cavity first trimester pregnancy unclear requires study
diabetes one high risk factors cardio cerebra vascular diseases including stroke atherosclerosis hypertension study conducted elucidate whether thromboxane receptor tpr activation contributes blood brain barrier bbb dysfunction diabetes human brain microvascular endothelial cells hbmecs cultured levels phosphorylated endothelial nitric oxide synthase enos ser enos akt ser akt assayed western blot exposure hbmecs either high glucose thromboxane txa mimetic significantly reduced enos akt effects abolished pharmacological genetic inhibitors tpr induced suppressions enos akt phosphorylation accompanied upregulation pten ser thr pten phosphorylation pten specific sirna restored akt enos signaling face tpr activation small gtpase rho also activated stimulation pretreatment hbmecs rho associated kinase rock inhibitor rescued impaired akt enos signaling stz injected rats found hyperglycemia dramatically increased levels pten pten ser thr phosphorylation reduced levels enos akt disrupted bbb function assayed evans blue staining abolished treatment conclude hyperglycemia activates thromboxane receptor impair integrity function blood brain barrier via rock pten akt enos pathway
open innovation means innovation fostered using external internal influences innovation process software engineering existed decades currently see faster broader move towards therefore survey research takes place contributes innovation study aims synthesize research knowledge domain launched systematic mapping study conducted thematic analysis results moreover analyzed strength evidence light rigor relevance assessment research identified publications divided themes related studies fall high rigor high relevance category suggesting results highly industry relevant research indicates start ups higher tendency opt compared incumbents evidence also suggests firms assimilating knowledge internal activities higher likelihood gaining financial advantages concluded adopted complementary approach facilitate internal innovation substitute research advised situated strategies interplay agile practices
paper concentrates modeling probabilistic events fuzzy probability measures object oriented databases instead crisp probability measures interval probability measures objects classes fuzzy sets used represent imprecise probability measures probabilistic object oriented database model fuzzy probability measures introduced incorporates fuzzy probability degrees handle imprecision uncertainty based proposed probabilistic object oriented database model several major semantic relationships probabilistic objects probabilistic classes fuzzy probability measures investigated paper finally define algebraic operations probabilistic objects probabilistic classes fuzzy probability measures
new cascadable voltage input current output first order pass filter applications second order filter oscillator presented proposed circuit employs single active element namely extra current controlled current conveyor cccii single grounded capacitor circuit exhibits high input high output impedances filter cascaded without additional buffers pole frequency electronically tunable circuit requires component matching constraints effects nonidealities parasitics also discussed applications second order transadmittance mode pass filter quadrature oscillator also realized using proposed voltage input current output first order pass filter examples validate easy cascading feature proposed circuit validity proposed circuit verified pspice simulations using parameters supply voltage
several studies confirmed maltreatment abuse childhood related conduct problems less known relationships concurrent adversities adolescence also compared severe adversities possible multiple additive effects study encompassed community population adolescents years age boys girls youth without conduct problem scores within deviant range strength difficulties questionnaire sdq compared concurrent adversities based self reports adolescents conduct problem scores within deviant range girls boys deviant conduct problem group experienced two concurrent adversities compared youths non deviant group likewise deviant conduct problem group times risk experiencing different adversities parental mental health problems experiences violence multivariately strongest associated conduct problem scores within deviant range sdq strong multiple additive relationship adversities found two thirds youth sdq conduct problem scores within deviant range reported two concurrent adversities clinicians seek information kinds amount possible traumatic adversities youth conduct problems offer evidence based treatment
last years success kernel based regularisation techniques solving impulse response modelling tasks revived interest linear system identification work alternative perspective problem introduced instead relying bayesian framework include assumptions system definition covariance matrix parameters prior knowledge injected cost function level key idea define regularisation matrix filtering operation parameters allows intuitive formulation problem engineering point view moreover results unified framework model low pass band pass high pass systems systems one resonances proposed filter based approach outperforms existing regularisation method based kernels illustrated means monte carlo simulations several linear modelling examples
purpose aim study evaluate effects nutraceuticals containing equol resveratrol quecitine passiflora zemiar avantgarde pomezia rome italy quality life qol sexual function perimenopausal women methods sixty perimenopausal women vasomotor symptoms straw system amenorrhea longer days fsh enrolled modified kupperman index used evaluate menopause symptoms short form female sexual function index fsfi female sexual distress scale fsds used assess qol sexual function sexual distress respectively study two follow ups months results women reported improvement total score baseline follow ups follow women reported qol improvements functions follow reported improvements categories baseline total fsfi score fsds score indicating sexual dysfunction sexual distress fsfi fsds total scores change follow contrary follow fsfi score risen fsds score dropped conclusion nutraceuticals effective modulating perimenopausal symptoms women progressive reduction vasomotor symptoms reported women nutraceutical usage could contribute improve qol sexual life
young adult cancer survivors report substantial distress social isolation body image concerns impede successful reintegration life years treatment completion mindful self compassion msc interventions focus developing mindfulness self compassion managing distress hardships perceived personal inadequacies msc intervention would beneficial supporting survivors management psychosocial challenges arise survivorship however telehealth intervention modality essential reaching geographically dispersed population conducted single arm feasibility study msc week videoconference intervention nationally recruited survivors ages msc intervention group based minute videoconference sessions held weekly weeks audio supplemented home practice feasibility acceptability assessed via attendance rate intervention satisfaction scale baseline post intervention changes psychosocial outcomes body image anxiety depression social isolation posttraumatic growth resilience self compassion mindfulness assessed using paired tests cohen effect sizes thirty four participants consented attended videoconference group feasibility established attending least six eight sessions intervention acceptability high score range psychosocial outcomes except resilience demonstrated significant changes survivors interested receiving msc videoconference intervention feasibility acceptance potential psychosocial benefits intervention demonstrated findings applied toward design efficacy randomized controlled trial improve quality life survivors transition cancer treatment
present study aimed examine difference self control strength individuals without antisocial personality disorder aspd chinese male prisoner sample thirty seven male inmates met criteria dsm aspd asked watch four minute silent videotape interview ignore words displayed screen videotape deplete ego strength handgrip task conducted watching videotape participants time squeezing handgrip dependent variable result showed significant interaction group aspd aspd group time baseline post manipulation measure post manipulation result significantly worse baseline result aspd group aspd group results indicate tasks contribute ego depletion lead deficit self control strength prisoners aspd
background despite improvements child survival past four decades estimated million children age five die year deaths occur neonatal period interventions reduce neonatal mortality needed kangaroo mother care kmc one life saving intervention however yet fully integrated health systems around world utilizing conceptual framework integration targeted health interventions health systems hypothesize caregivers play critical role adoption diffusion assimilation kmc objective research identify barriers enablers implementation scale kmc caregivers perspective methods searched pubmed embase web science scopus regional databases using search terms kangaroo mother care kangaroo care skin skin care studies published january august included eligible published work based primary data collection regarding barriers enablers kmc implementation family perspective abstracted data linked conceptual framework using deductive approach themes identified within five framework areas using nvivo software results identified total abstracts removing duplicates ineligible studies included analysis majority publications published within past years sample size less recruited participants health facilities approximately one third studies conducted americas conducted africa identified four themes surrounding interaction families kmc intervention buy bonding benefits kmc mothers infants perceptions bonding mother infant social support assistance people perform kmc sufficient time perform kmc medical concerns mother newborn health furthermore identified barriers enablers kmc adoption caregivers within context health system regarding financing service delivery embedded within broad social context barriers kmc adoption caregivers included adherence traditional newborn practices stigma surrounding preterm infant gender roles regarding childcare conclusion efforts scale integrate kmc health systems must reduce barriers order promote uptake intervention caregivers
use renewable materials essential future technologies harmonize living environment renewable materials maintain resources environment overcome degradation natural environmental services diminished productivity paper reviews recent advancement renewable materials smart material applications including wood cellulose chitin lignin sensors actuators energy storage applications improve functionality renewable materials hybrid composites inorganic functional materials introduced incorporating carbon nanotubes titanium dioxide tin oxide conducting polymers ionic liquids since renewable materials many advantages biocompatible sustainable biodegradable high mechanical strength versatile modification behaviors research efforts need focused development renewable smart materials
directed forgetting requires voluntary control memory whereas many studies examined directed forgetting long term memory ltm mechanisms effects directed forgetting within working memory less well understood current study tests directed forgetting instructions delivered task influence veridical memory well false memory short long term modified item recognition task experiment tested demonstrated directed forgetting reduces false recognition errors semantic interference experiment replicated effects used surprise ltm recognition test assess long term effects directed forgetting long term veridical memory remembered lists better memory forgotten liststhe directed forgetting effect moreover fewer false memories emerged forgotten information remembered information ltm well results indicate directed forgetting reduces semantic processing forgotten lists short long term implications theories false memory mechanisms directed forgetting within working memory discussed
effects brown rot decay mechanical chemical properties poplar populus cathayana rehd wood investigated correlation several properties decay degree quantified decay process losses impact bending strength ibs modulus rupture mor increased logarithmically degree decay whereas losses modulus elasticity moe compressive strength parallel grain csi increased slowly linear trends ranking four mechanical parameters response speed decay degree influence decay ibs mor moe csi hemicelluloses preferably decomposed brown rot fungus prominent degradation cellulose began weight loss relative crystallinity decreased summary degradation hemicelluloses caused fast significant decrease ibs subsequent removal paracrystalline cellulose resulted mor loss variation moe correlation cellulose content decrease csi due slow deterioration crystalline cellulose
research examining children sexual behavior problems sbp almost exclusively relies caregiver reports current study involving sample children drawn prospective study utilizes child self reports teacher reports well caregiver reports first analyses examined children displaying sbp second set analyses specifically examined children displaying interpersonal forms sbp caregivers reported greater internalizing externalizing social problems children general sbp interpersonal sbp compared children without sbp caregiver concerns rarely corroborated teacher child reports protective services records indicated sbp linked childhood sexual abuse sexual abuse occurred minority cases physical abuse common among children interpersonal forms sbp data current study suggest need multiple reporters assessing children presenting sbp conventional views children may misleading
recent years vietnam seen rapidly expanding transport infrastructure especially roads bridges latter ones large size structures determined geological features area high number large rivers significant part bridges country cable stayed first large cable stayed bridge thuan completed whereas tho bridge completed cable stayed bridge largest span length vietnam cable stayed bridges effective structures due lightweight decks large lever arms forces important element impressive elegant structures closely spaced wire cables transmit loads pylons foundations today vietnam several structures type largest cable stayed bridge nhat tan bridge connecting hanoi airport completed noi bai international airport center hanoi separated wide red river thang long bridge built years ago connection across river nhat tan bridge alternative direct access road shortening travel time airport main bridge long cable stayed structure many spans rare type bridge world one longest bridges southeast asia bridge gateway hanoi also serves symbol friendship vietnam japan article presents design bridge course construction technologies applied present several large bridges also construction throughout country authors published elsevier ltd
design integrated coastal berths entrance channel system complex challenge considering stochastic environment time consuming calculation works therefore authors implement decision support system dss designing integrated coastal berths entrance channel systems icbecs dss means simulation parallel computing icbecs dss provides three dimensional integrated design environment broad set fully integrated functions evaluate proposed design alternatives identify optimal design large number alternatives key components icbecs dss process interaction based simulation model ship operation smso java parallel processing framework based parallel computing program jppf pcp smso component simulates ships one two way traffic channel one way channel ships passing anchorage along channel spac ships discharging loading berths jppf pcp component provides parallel computing environment reduce processing time running large number simulation experiments finally icbecs dss applied case study coal terminal decides whether expansion projects needed proposes expansion strategies improve port performance results prove icbecs dss performs well helpful effectively designing berths entrance channels together therefore icbecs dss used support decision making integrated berths entrance channel systems provides reference government agencies involved design operation port systems
objectivecardiac rehabilitation considered recommended secondary prevention treatment cardiovascular diseases cvd terms health behaviours secondarily better cardiac outcomes promotion however role psychiatric psychosomatic distress efficacy unclear research aimed evaluate impact unhealthy behaviour modification cardiac course considering moderating role depression anxiety psychosomatic syndromes designa longitudinal design within groups employed assessment repeated four times admission discharge months following completion methodone hundred eight patients undergoing versus patients cvd referred underwent psychiatric psychosomatic health behaviour assessment assessment included structured clinical interview dsm depression anxiety interview based diagnostic criteria psychosomatic research gospel study questionnaire health behaviours pittsburgh sleep quality index item morisky medication adherence scale resultscardiac rehabilitation associated maintenance physical activity improvement behavioural aspects related food consumption stress management sleep quality contrary associated weight loss healthy diet medication adherence depression psychosomatic syndromes seem moderate modification specific health related behaviours physical activity behavioural aspects food consumption stress management pharmacological adherence conclusionin settings integrated assessment including psychiatric psychosomatic syndromes needed address psychological factors associated unhealthy behaviour modification
importance skyline dominance relationship analysis well recognized multicriteria decision making applications paper propose problem finding skyline customer preferences cost constraints utilizes concept dominance business analysis microeconomic perspective problem aims discover dominance relationship products potential customers given set customer preferences want help company design set competitive products products satisfy many customer requirements possible cost producing products within specified threshold competitive products mean products dominated products market formally define problem discuss difficulty problem also present foundation intuition pruning methods proposed three efficient algorithms utilize pruning methods address problem addition also prove correctness proposed algorithms
many women elevated risk hereditary breast ovarian cancer previously tested negative pathogenic mutations brca brca among subset hereditary susceptibility cancer requires testing sought identify specific groups remain high risk evaluate whether offered multi gene panel testing tested women multi gene panel previously enrolled long term study ucsf part long term care previously tested negative mutations brca brca either limited comprehensive sequencing additionally met one following criteria personal history bilateral breast cancer personal history breast cancer first second degree relative ovarian cancer iii personal history ovarian fallopian tube peritoneal carcinoma across three groups women total pathogenic mutations associated hereditary cancer susceptibility women mutations genes brca brca ashkenazi jewish hispanic women elevated pathogenic mutation rates addition two women harbored pathogenic mutations one hereditary predisposition gene among women high risk breast ovarian cancer previously tested negative pathogenic brca brca mutations identified three groups women considered subsequent multi gene panel testing identification women multiple pathogenic mutations important implications family testing
background cow milk allergy one common food allergies affecting young children subset milk allergic individuals eat baked milk without allergic symptoms beneficial terms prognostication liberalization diet retrospective study suggested skin prick testing spt baked milk muffin slurry may provide sensitive means predicting outcome medically supervised baked milk oral food challenge evaluated predictive value spt baked milk identify unheated milk allergic children able safely eat baked milk methods children aged years prior history reaction milk milk extract spt recruited investigator blinded spt muffin slurry powdered milk triplicate specific ige sige casein milk performed graded oral challenge egg free baked milk muffins total milk protein performed hospital reliability tests analyzed intraclass correlation statistical significance clinical characteristics population muffin testing versus baked milk reactivity calculated fisher exact test dichotomous test continuous variables wilcoxon rank sum test used compare immunological characteristics individuals tolerated reacted baked milk fitted predicted probability curves roc curves generated results thirty eight children consented met study criteria muffin spt casein sige significantly different passed versus failed baked milk challenge negative baked milk tests found children associated non reactivity baked milk sensitivity children negative spt baked milk passed oral challenge specificity optimal decision point muffin spt casein sige powdered milk test helpful conclusions skin prick testing baked milk muffin slurry may role clinical practice identify baked milk tolerance milk allergic patients
fractional calculus studied three centuries multifarious applications science engineering review investigates progress since first reported use control systems covering fractional pid proposed podlubny presenting state art fractional pid controller incorporating latest contributions field highlights developments field fractional pid controllers including design tuning well explores various versions software tools associated design fractional pid controllers also discussed elsevier ltd rights reserved
article reviews current state diagnosis treatment schizophrenia describing recent proliferation research high risk psychosis spectrum conditions different childhood onset early onset schizophrenia findings psychotic like experiences normal population taken adult childhood literature clinical quandaries accurate diagnosis treatment gaps occurring sometimes confounding conditions discussed thoughts impact schizophrenia emerging adulthood trajectory offered recent best practices treatment schizophrenia consistent recovery oriented model mental health services transitional age youth
overcome drawbacks plasma stealth technology real life application practical multilayer stealth structure composed enclosed plasma slab radar absorbing material ram presented paper based technique referred transmission line analogy method reflection coefficients perpendicularly polarized wave parallel polarized wave circularly polarized wave obliquely incident upon multilayer structure determined respectively effects incident angle kinds rams parameters plasma slab including electron density collision frequency thickness stealthy effectiveness composite stealth structure studied systematically numerical results indicate proper design power reflected wave significantly reduced wide frequency bandwidth provides useful references plasma stealth technology applied aircrafts ships missiles
emotions sensory perceptions closely intertwined five senses sight far extensively studied sense emotion research relatively less known emotions influence four senses touch essential nonverbal communication humans animals current investigation tested competing hypotheses effect fear tactile perception one hypothesis based evolutionary considerations predicts fear enhances sensory perception including tactile sensitivity competing hypothesis based research peripheral psychophysiology predicts fear decrease tactile sensitivity two experiments induced negative emotional states measured two point discrimination ability fingertip found fear reduces tactile sensitivity relative anger neutral control condition studies findings appear driven participants naive beliefs influence emotions touch study results represent first evidence causal impact emotional states tactile sensitivity consistent prior evidence peripheral physiological effects fear offer novel empirical grounds developing advancing theories emotional influences sensory perception
recent work patient reported outcomes pros focuses precise brief measures generally convey little individual rating actually means individual differences appraisal important relevant pro research paper highlights advantages integrating appraisal assessment clinical research comprehensive method assessing appraisal quality life qol appraisal profile includes open ended multiple choice questions assess four appraisal parameters frame reference sampling experience standards comparison combinatory algorithm illustrate empirical findings four classes investigation would benefit appraisal assessment methodological interpretation change backstory resilience clinical applications methodological investigation hiv aids patients revealed range cognitive schemas induced test response shift detection method reflected presumed process invoked study study people multiple sclerosis interpretation change positive versus negative mental health response shifts characterized different appraisal processes studying resilience patients patients reserve building activities likely use appraisals emphasized positive controllable aspects illness experience compared lower reserve patients underserved cancer patients qol appraisal profile used clinical interview articulate current concerns personalized treatment decision making reduce burden promote adherence integrating appraisal assessment provide textured person centered understanding person factors captured standard pros
due consideration growing importance chemical sensors detection quantification toxic heavy metal ions counter water pollution novel class tellurium based organic receptors investigated potentially sensitive selective silver ion probe present work new tellurium incorporated schiff base ligand chemically synthesized characterized using various spectroscopic techniques upon exposure organic nanoparticles title receptor ligand pool select heavy metal ions former displayed high sensitivity selectivity towards silver ions aqueous medium detection limit interestingly presence metal ions bearing close physico chemical resemblance silver exerted negligible interference ultra sensitive detection silver ions title probe furthermore precision accuracy potential silver ion sensor aqueous medium established across wide range well saline conditions analytical utility potential silver ion probe investigated real sample analysis objects environmental applicability results authenticated using atomic absorption spectroscopy summary investigation utility new class tellurium based organic receptors potential metal ion sensors opens new avenue rather poorly comprehended environmental relevance organotellurium chemistry published elsevier ltd
present context energy access remote rural households local energy generating systems recognized cost effective extent efficient option increased emphasis ecofriendly technologies high fuel cost associated conventional energy generation use renewable energy resources small hydro biomass solar wind energy etc explored present paper focused optimal sizing stand alone integrated renewable energy system ires comprises resources micro hydro power mhp biogas biomass solar wind energy initially demand response strategy based energy consumption scheduling appliances suggested modelled paper strategy aims minimize peak hourly energy consumption study area different combinations system components without strategy considered optimized power reliability criteria unmet load found significant amount savings system sizes costs obtained strategy compared system without elsevier ltd rights reserved
development green roof market greece mediterranean countries general standardized unlike germany northern european countries construction successful sustainable green roofs relies mainly development combination integrated systems include green roof stabilization appropriate selection substrate drainage system support sustainable plant growth current study provides thorough review decision making process associated selection substrate drainage slope reinforcing materials athens concert hall green roof park scope study guidelines different scientific fields modified combined accommodate specifics project hellenic climatic conditions challenges addressed included roof shell different inclinations underground retaining walls steps steep slopes reached gradients selection appropriate materials methodologies supported analyses included granulometry bulk density hydraulic conductivity moisture potential curves organic matter content weight saturation field capacity drainage layer consisted bilayered system pea gravel sand combined geotextiles substrate characteristics defined analyses undertaken adapted hellenic climatic conditions geogrids honeycomb geocells utilized separately conjunction inclined surfaces substrate moisture measurements performed locations green roof revealed increased moisture fluctuations mainly caused presence underground retaining walls
last two decades wealth research domain episodic memory focused understanding neural correlates mediating false memories memories events never happened several recent qualitative reviews attempted synthesize literature methodological differences amongst empirical studies focus sub set findings limited broader conclusions regarding neural mechanisms underlying false memories current study performed voxel wise quantitative meta analysis using activation likelihood estimation investigate commonalities within functional magnetic resonance imaging fmri literature studying false memory results broken memory phase encoding retrieval well sub analyses looking differences baseline hit correct rejection memoranda verbal semantic experimental paradigm semantic relatedness perceptual relatedness within retrieval concordance maps identified significant overlap across studies analysis several regions identified general false retrieval analysis well multiple sub analyses indicating ubiquitous yet critical role false retrieval medial superior frontal gyrus left precentral gyrus left inferior parietal cortex additionally several regions showed baseline paradigm specific effects hit perceptual relatedness inferior middle occipital gyrus crs bilateral inferior parietal cortex precuneus left caudate respect encoding analyses showed common activity left middle temporal gyms anterior cingulate cortex analysis identified common cluster activation medial temporal lobe elsevier ltd rights reserved
first study assess global methylation oxidative dna damage lipid peroxidation workers occupational exposure metal oxide nanomaterials nms urinary white blood cell wbc hydroxydeoxyguanosine ohdg exhaled breath condensate ebc isoprostane measured oxidative stress biomarkers wbc global methylation measured epigenetic alteration exposure tio sio indium tin oxide ito resulted significantly higher oxidative biomarkers urinary ohdg ebc isoprostane however significantly higher wbc ohdg lower global methylation observed ito handling workers significant positive correlations noted wbc urinary ohdg spearman correlation furthermore significant negative correlation found wbc ohdg global methylation results suggest exposure metal oxide nms may lead global methylation dna oxidative damage lipid peroxidation elsevier rights reserved
paper theoretical background electromagnetic induction modeling presented response function homogenous sphere shaped sample ferromagnetic non ferromagnetic material introduced experimental data measured metal detector excited polyharmonic signal also presented
recent studies indicate transient memory errors soft errors become relevant source system failures paper presents generic software based fault tolerance mechanism transparently recovers memory errors object oriented program data structures main benefits flexibility choose extensible toolbox easily pluggable error detection correction schemes hamming crc codes achieved combination aspect oriented generative programming techniques furthermore present wait free synchronization algorithm error detection data structures used concurrently multiple threads control give formal correctness proof show excellent scalability approach multiprocessor environment case study present experiences selectively hardening ecos operating system benchmark suite explore trade resiliency performance choosing vulnerable data structures error recovery thereby total number system failures manifesting silent data corruptions crashes reduced percent negligible runtime overhead percent
paper describes research design behavioral mental health facilities using input clinical staff purpose study four fold develop test tool evaluation mental behavioral health mbh facilities evaluate importance effectiveness specific environmental qualities features generate design guidelines mbh facilities make recommendations future research draft version tool intended measure importance effectiveness environmental qualities features mbh facilities developed using multi methods approach survey psychiatric staff environmental design psed tool distributed psychiatric nursing organization members researchers determined psed suitable future research minor modifications findings included staff support private patient rooms staff recognition critical role positive distraction importance aesthetics elsevier ltd rights reserved
examined whether positive negative affect motivates verbal spatial working memory processes respectively implications expenditure mental effort argue emotion promotes cognitive tendencies goal incompatible task demands greater cognitive effort required perform well sought investigate whether increase cognitive effort impairs behavioural control broad domain self control tasks moreover predicted individuals higher behavioural inhibition system bis sensitivities would report negative affect within goal incompatible conditions individuals report higher negative affect cognitive challenge positive negative affective states induced followed completing verbal spatial back working memory task participants completed one three self control tasks overall observed conditions emotion working memory incompatibility positive spatial negative verbal performed worse self control tasks within incompatible conditions individuals higher bis sensitivities reported negative affect end study combination findings suggests emotion working memory compatibility reduces cognitive effort impairs behavioural control
countries usa gay bisexual men experience high rates intimate partner violence however little known factors contribute form violence study examine gay bisexual men perceptions sources tension sex male relationships may contribute intimate partner violence conducted seven focus group discussions gay bisexual men atlanta focus groups examined men reactions short form revised conflicts tactics scale determine item considered intimate partner violence occur among gay bisexual men analysts completed thematic analysis using elements grounded theory sources tension men identified included gender role conflict dyadic inequalities differences income age education differences outness sexual identity substance use jealousy external homophobic violence results suggest intimate partner violence interventions gay bisexual men address behavioural factors also focusing structural interventions interventions aim reduce homophobic stigma redefine male gender roles may help address tension contributes intimate partner violence sex male relationships resumedans des pays comme les etats unis taux violence entre partenaires intimes est eleve parmi les hommes gays bisexuels les connaissances restent cependant limitees sur les facteurs influence cette forme violence dans cette etude nous examinons les perceptions hommes gays bisexuels sur les sources tension sein des relations intimes entre hommes comment ces perceptions peuvent contribuer violence entre partenaires intimes nous avons conduit sept groupes discussion thematique avec hommes gays bisexuels atlanta ces groupes nous ont permis examiner comment reagissaient les participants une forme abregee echelle des tactiques conflits dans une version revisee pour determiner chacun des enonces renverrait qui devait etre considere comme violence entre partenaires intimes produisait entre hommes gays bisexuels une analyse thematique ete realisee partir elements theorie ancree les sources tension identifiees par les participants comprennent les conflits roles genre les inegalites dyadiques par les differences revenu age education les differences des degres affirmation identite sexuelle abus substances jalousie violence externe caractere homophobe les resultats suggerent que les interventions centrees sur violence entre partenaires intimes ciblant les hommes gays bisexuels doivent prendre compte les facteurs comportementaux tout concentrant sur des interventions structurelles les interventions visant reduire stigmatisation homophobe redefinir les roles genre masculin peuvent aider reduire certaines des tensions qui contribuent violence sein des relations entre partenaires intimes masculins resumenen paises como los estados unidos nivel violencia pareja entre hombres homosexuales bisexuales muy alto sin embargo poco sabe sobre los factores que contribuyen este tipo violencia este estudio analizamos que piensan los hombres homosexuales bisexuales sobre cuales son las fuentes tension las relaciones masculinas con personas del mismo sexo como contribuyen estas fuentes violencia pareja para ello llevamos cabo siete charlas grupo con hombres homosexuales bisexuales atlanta georgia las charlas grupo examino como reaccionaban los hombres las cuestiones escala tacticas conflicto revisada breve con objetivo determinar consideraban que los diferentes aspectos representaban violencia pareja ocurrian entre hombres homosexuales bisexuales los analistas completaron analisis tematico utilizando elementos teoria fundamentada las fuentes tension que los hombres identificaron fueron conflicto con los roles genero desigualdades diadicas diferencias ingresos edad formacion diferencias cuanto franqueza sobre identidad sexual uso estupefacientes celos violencia homofobica externa los resultados indican que los programas para evitar violencia pareja entre hombres homosexuales bisexuales seria preciso tener cuenta los factores comportamiento centrarse ademas intervenciones estructurales los programas que tienen como finalidad reducir estigma homofobico redefinir los papeles genero masculino podrian servir para tratar algunas las tensiones que contribuyen violencia pareja las relaciones intimas entre hombres homosexuales
backgroundwhile association pre pregnancy body mass index bmi hypertensive disorders pregnancy hdp well documented little known relationship pre pregnancy weight change hdp examined impact adult pre pregnancy weight change development hdp methodswe included women surveyed every three years since cohort australian longitudinal study women health women without hypertension hdp followed generalised estimating equations used assess effect baseline bmi mean age years pre pregnancy weight change incidence hdp resultsover years follow incident hdp cases reported pregnancies overweight obese women baseline survey times likely develop hdp normal weight women respectively compared stable weight women women small moderate high annual weight gain elevated risk hdp respectively women reported annual weight loss baseline average age years less likely develop hdp conclusionspre pregnancy weight gain associated increased risk hdp whereas early adult weight loss associated lower risk hdp
microteaching gained considerable attention effectiveness rapid contextual training professional development programs however interpretive quality teaching demonstration peer feedback may influence individuals attribution self correction leading ineffective learning study microteaching workshop professional development program elementary school science teachers investigated results showed effectiveness microteaching negatively affected participants perception bias due social categorization moreover indicated participants perception group group classified degree individuals science knowledge fostered social categorization participants tended experience perception conflicts caused inability see personal faults typical perception bias seeing one strengths seeing others shortcomings frequently recognized group results converge highlight importance social categorization perception bias relevant microteaching
set algorithms simultaneous localization mapping industrial television systems discussed probabilistic model problem described fastslam algorithm example possibility using sigma point kalman filter estimating movement spatial landmarks key feature images characterized stable detection recognition within video stream considered general model camera motion method evaluating spatial position using particle filter presented
antimicrobial peptides amps indivisible part innate immune system invertebrates amps proven crucial role wide range biological activities mainly immunomodulatory broad spectrum antimicrobial activity various pathogens unique salient features amps show exceptional nature therapeutic activity serves alternative agent conventional antibiotics search potential amps persist emergence multiple drug resistant bacterial strains spreading higher number putative antimicrobial peptide sequences identified sequences prawn transcriptome analyzed various silico tools expasy ampa helical wheel projection characteristic antimicrobial properties determined putative amps mentioned tools demonstrated efficient bioinformatics approach derive analyze amps transcriptome data macrobrachium rosenbergii even though peptide regions identified among five peptide sequences demonstrated comprehensively characteristic property contributes antimicrobial activity study proposed rapid successful protocol would help predict amp sequential procedure using various silico methods also shown distinctive method shortlist amps based various physico chemical properties sequential protocol developed identify characterize amps protein database
past decades tremendous effort put research development improved building systems technologies reduce building energy consumption advance energy efficiency however little published quantifiable evidence assesses energy consumption efficiency residential buildings context green building standards fill gap information paper reports empirical study investigates green home energy efficiency interaction resident behaviors work uses integrated approach energy simulation multivariate regression modeling data sample residential units meet green building standards findings identify annual reduction energy usage energy expenditures typical american home findings also identify four energy consumption related resident behaviors depending actual energy efficiency performance green building technology may differ authors published elsevier ltd
background family planning key help individuals couples avoid unwanted births regulate interval pregnancies control time birth occurs relation age parents determines number children family objectives investigate knowledge practice contraceptive methods among educated working women assess women knowledge attitude practice relation emergency contraception material methods cross sectional study conducted respondents among educated working women guntur women reproductive age group years interviewed administering pretested mixed questionnaire containing open closed ended questions taking informed consent collected data compiled processed analyzed results women aware contraceptive methods married women women practiced contraception total women practiced temporary permanent methods respectively major source information electronic print media followed medical literature women women aware emergency contraception women practiced emergency contraception conclusions awareness usage contraception high educated working women population permanent method preferred temporary methods however low percentage women aware emergency contraception hence programs must implemented create awareness emergency contraception
effects multiple insect attacks herbivore induced plant volatiles carnivorous arthropods increasingly studied phytopathogens also represent important threat plants plant defence strategies pathogens insects strongly interconnected yet potential impact pathogens insect induced volatiles largely overlooked degree pathogenicity rarely considered investigated pathogen challenge virulent avirulent strains xanthomonas campestris either alone simultaneous pieris brassicae caterpillar herbivory affected volatile emissions brassica nigra plants impact volatiles foraging behaviour cotesia glomerata parasitoids wasps assessed pathogens induced volatiles highly attractive parasitoids enhanced attractiveness host infested plant volatiles chemical analyses revealed virulent avirulent strains differentially induced plant volatiles primarily sesquiterpene homoterpene green leaf volatile compounds contributing differences strong similarities found blends induced virulent strain caterpillar herbivory challenge either virulent avirulent pathogens significant impact plant chemistry interactions community members demonstrating importance integrating pathogen insect based research broaden knowledge plant defences conditions increasing complexity
despite advances early diagnosis behavioral therapies effective treatments children autism spectrum disorder asd needed hypothesized umbilical cord blood derived cell therapies may potential alleviating asd symptoms modulating inflammatory processes brain accordingly conducted phase open label trial assess safety feasibility single intravenous infusion autologous umbilical cord blood well sensitivity change several asd assessment tools determine suitable endpoints future trials twenty five children median age years range confirmed diagnosis asd qualified banked autologous umbilical cord blood unit enrolled children evaluated battery behavioral functional tests immediately prior cord blood infusion baseline months later assessment adverse events across month period indicated treatment safe well tolerated significant improvements children behavior observed parent report measures social communication skills autism symptoms clinician ratings overall autism symptom severity degree improvement standardized measures expressive vocabulary objective eye tracking measures children attention social stimuli indicating measures may useful endpoints future studies behavioral improvements observed first months infusion greater children higher baseline nonverbal intelligence quotients data serve basis future studies determine efficacy umbilical cord blood infusions children asd
soil geosynthetic interface shear strength essential parameter design stability analysis geosynthetic reinforced soil structures economic environmental reasons led increasing use locally available residual soils significant percentage fines lower draining capacity compared traditional good quality backfill materials paper describes extensive laboratory study carried using large scale direct shear test device influence soil moisture content soil density geosynthetic type direct shear behaviour soil geosynthetic interface evaluated study involved locally available granite residual soil four geosynthetics two geogrids one uniaxial biaxial one geocomposite reinforcement high strength geotextile one geotextile test results revealed increase soil moisture content measurably reduce soil geosynthetic interface shear strength regardless soil moisture content soil density proved remarkable influence interface shear strength particularly geogrids used among different geosynthetics tested biaxial geogrid found effective reinforcement particular type soil concerning direct shear mechanism soil geogrid interfaces coefficients interaction ranged soil geotextile interfaces coefficients interaction varied
retroesophageal left brachiocephalic vein extremely rare anomaly reported postnatal cases two prenatally diagnosed cases reported vessel view vein appears aberrant vessel transversely coursing behind aorta trachea subsequently drains superior vena cava giving rise shaped configuration color doppler sonography sign bicolored anomaly prompt sonographer carefully assess congenital heart defects suggest consideration genetic testing alert cardiologist could affect central line procedures cardiac interventions delivery
qualitatively analyzing responses letter writing homework media literacy education program study examines sixth graders understandings producers responsibility creating media content responses suggest understandings producers responsibility bounded within context media use consumers rather citizens findings focus importance introducing contextual factors media production well challenges researchers educators might face
although frequency specific network analyses shown functional brain networks altered patients alzheimer disease relationships frequency specific network alterations remain largely unknown multiplex network analysis novel network approach study complex systems consisting subsystems different types connectivity patterns study used magnetoencephalography integrate five frequency band specific brain networks multiplex framework previous structural functional brain network studies consistently shown hub brain areas selectively disrupted alzheimer disease accordingly hypothesized hub regions multiplex brain networks selectively targeted patients alzheimer disease comparison healthy control subjects eyes closed resting state magnetoencephalography recordings patients alzheimer disease years females controls years females projected onto atlas based regions interest using beamforming subsequently source space time series cortical subcortical regions reconstructed five frequency bands delta theta alpha alpha beta band multiplex brain networks constructed integrating frequency specific magnetoencephalography networks functional connections pairs regions interests quantified using phase based coupling metric phase lag index several multiplex hub heterogeneity metrics computed capture overall importance brain area heterogeneity connectivity patterns across frequency specific layers different nodal centrality metrics showed consistently several hub regions particularly left hippocampus posterior parts default mode network occipital regions vulnerable patients alzheimer disease compared control subjects note detected vulnerable hubs alzheimer disease absent individual frequency specific network thus showing value integrating networks connectivity patterns vulnerable hub regions patients heterogeneously distributed across layers perturbed cognitive function abnormal cerebrospinal fluid amyloid beta levels correlated positively vulnerability hub regions patients alzheimer disease analysis therefore demonstrates magnetoencephalography based multiplex brain networks contain important information revealed frequency specific brain networks furthermore indicates functional networks obtained different frequency bands act independent entities overall multiplex network study provides effective framework integrate frequency specific networks different frequency patterns reveal neuropathological mechanism hub disruption alzheimer disease
paper presents dynamic model design method electric surface vessel dynamic model consists hull electric motor rudder system model designed based physical properties hull model represented dof motor physical domain rudder dof model complete model electric surface vessel verified simple navigation simulation path navigation generated cubic spline curve fitting method simulation result verifies relationship dynamic responses model
current guidelines treatment anorexia nervosa children adolescents recommend integrated multidisciplinary approach elective intervention disorder nevertheless insufficient evidence results integrated approach treatment adolescent patients especially hospital setting study aims analyze clinical psychological changes occurring adolescent patients completion day hospital multifocal integrated treatment mit anorexia nervosa sample consisted adolescents eating disorder otherwise specified ednos restrictive type aged years parents clinical course evaluated month follow periods results showed clinical remission good percentage patients general found significant reduction eating psychopathology whereas detect significant improvement body dissatisfaction perfectionism relational difficulties positive trend confirmed month follow despite increase drop outs results suggest proposed treatment reasonably effective aims contain reduce acute phase disease limited time hospital setting necessary continue treatment targeted psychotherapeutic interventions address deeper psychological discomfort underlying eating disorder
introduction ultrasound rapidly evolving technique gaining increasing success assessment psoriatic arthritis psa recently new research avenues opened focused potential assessment extra musculoskeletal areas skin nails permits work concept holistic assessment psa areas covered analyze potential role global assessment psa additionally provide current evidence supporting application routine clinical practice literature obtained medical databases including pubmed embase expert commentary detect structural abnormalities also minimal blood flow changes superficial soft tissue level makes great tool global assessment disease activity psa persistently active disease plays major role causing anatomical damage physical functional disability
danish study functional disorders danfund cohort initiated outline epidemiology functional somatic syndromes fss first larger coordinated epidemiological study focusing exclusively fss fss prevalent medical settings defined syndromes appropriate medical assessment explained terms conventional medical surgical disease fss frequent clinical importance varies vague symptoms extreme disability well described medical explanations exist fss delimit fss remains controversial topic specific aims cohort test delimitations fss estimate prevalence incidence rates identify risk factors delimitate pathogenic pathways explore consequences fss study population comprises random sample men women aged years general population examined survey comprises screening questionnaires five types fss fibromyalgia whiplash associated disorder multiple chemical sensitivity irritable bowel syndrome chronic fatigue syndrome unifying diagnostic category bodily distress syndrome additional data included telephone based diagnostic interview assessment fss questionnaires physical mental health personality traits lifestyle use health care services social factors physical examination measures cardiorespiratory morphological fitness metabolic fitness neck mobility heart rate variability pain sensitivity biobank including serum plasma urine dna microbiome established central registry data responders nonresponders similarly available morbidity mortality reimbursement medicine heath care use social factors complete year follow scheduled take place year reexaminations planned several projects using danfund data ongoing findings published coming years
article evaluates proposition relationship family state central study american political development compares parallel efforts pioneering feminist political legal theorists put table issues public private distinction polity family assumptions role family women wifely maternal labor political order injustice within family illustrates legal scholars regularly examine evolution time family definitions forms gender roles also evolution various forms state regulated supported family article suggests study american political development big tent within scholars diverse disciplines may benefit fruitful conversations parallel inquiries indicate importance contextual temporal examination family state article analyzes recent landmark supreme court opinion obergefell hodges held sex couples may exercise fundamental right many every state
objectives quality life sense physical psychological well concept affected various factors place residence present study conducted aim explore quality life postmenopausal women urban rural areas tabriz iran materials methods present cross sectional study conducted postmenopausal women rural urban areas selected cluster sampling method data collected part questionnaire consisting demographic details quality life research made questionnaire assessment physical psychological menopausal symptom results following adjustment basic variables rural women obtained significantly higher scores physical function general health vitality although subscales bodily pain social function role limitation better urban women multivariate linear regression results revealed factors affecting quality life including number children satisfaction children conduct income occupation score postmenopausal symptoms urban women satisfaction children conduct income chronic diseases age postmenopausal duration education score postmenopausal symptoms rural women conclusion present study results showed various dimensions quality life acceptable level two groups significantly different subscales considering increasing middle aged older population attention quality life women age groups crucial present study determined difference dimensions quality life urban rural women identified possible health requirements
rapid development mobile app market understanding determinants mobile app success become vital researchers mobile app developers extant research mobile applications primarily focused numerical textual attributes apps minimal attention provided visual attributes apps affect download behavior users among features app appearance study focuses effects app icon demand aesthetic product interface design theories analyze icons three aspects namely color complexity symmetry image processing using dataset collected one largest chinese android websites find icon appearance influences download behavior users particularly apps icons featuring higher colorfulness proper complexity slight asymmetry lead downloads findings help developers design apps
astrocytes play crucial roles brain homeostasis emerging regulatory elements neuronal synaptic physiology responding neurotransmitters elevations releasing gliotransmitters activate neuronal receptors aging involves neuronal astrocytic alterations considered risk factor neurodegenerative diseases evidence astrocyte neuron signaling derived studies young animals however features astrocyte neuron signaling adult aging brain remain largely unknown investigated existence properties astrocyte neuron signaling physiologically pathologically aging mouse hippocampal cortical slices different lifetime points month old animals found astrocytes preserved ability express spontaneous neurotransmitter dependent intracellular signals juvenile aging brains likewise resting levels gliotransmission assessed neuronal nmdar activation glutamate released astrocytes largely preserved similar properties tested age groups dhpg induced gliotransmission reduced aged mice contrast gliotransmission enhanced app mouse model alzheimer disease indicating dysregulation astrocyte neuron signaling pathological conditions disruption astrocytic mediated signaling required neurotransmitter induced astrocyte signals gliotransmission boosted progression amyloid plaque deposits synaptic plasticity impairments app mice early stages disease therefore astrocyte neuron interaction fundamental signaling largely conserved adult aging brain healthy animals altered alzheimer disease suggesting dysfunctions astrocyte physiology may contribute neurodegenerative disease
study report unusual case mutidimensional sensorimotor cognitive socio affective preservation adult extensive acquired bilateral brain damage age patient sustained cerebral hemorrhage months later suffered second ischemic stroke result exhibited extensive damage right hemisphere including frontal temporal parietal occipital regions left sylvian striatal areas bilateral portions insula amygdala splenium however probability unimpaired across host cognitive domains including executive functions attention memory language sensory perception taste recognition intensity discrimination emotional processing experiencing positive negative emotions social cognition skills prosody recognition theory mind facial emotion recognition emotional evaluation functional integrity confirmed neurological examination contextualized observation performance real life tasks sum case resists straightforward classifications extent distribution lesions would typically produce pervasive multidimensional deficits discuss rarity patient backdrop reports atypical cognitive preservation expound limitations several potential accounts highlight challenges case poses current theories brain organization resilience
approach estimation parametric discrete time model process case priori knowledge investigated process properties presented knowledge plant properties introduced form linear bounds determined coefficient vector parametric model studied approach yields special biased estimation model coefficients preserves demanded properties formula estimation model coefficients derived combined recursive scheme determined minimization sum absolute model errors estimation problem model known static gains inputs discussed proper formulas derived approach overcome non identifiability problem observed estimation based measurements recorded industrial closed loop control systems application proposed approach estimation model industrial plant water injector steam flow power plant presented discussed
study high performance high speed field programmable gate array fpga implementations polynomial basis itoh tsujii inversion algorithm ita constructed irreducible trinomials pentanomials presented proposed structures designed one field multiplier times squarer blocks exponentiation small positive integer times squarer blocks efficient tree structure low critical path delay multiplier based proposed high speed digit serial architecture minimum hardware resources furthermore reduce computation time ita critical path circuit broken finer path using several registers computation times structure virtex fpga family respectively comparison results implementations polynomial basis itoh tsujii inversion algorithm verify improvement proposed architecture terms speed performance
background diagnostic evaluation patients diffuse parenchymal lung disease dpld best achieved multidisciplinary team correlating clinical radiological pathologic features surgical lung biopsy remains gold standard histopathologic diagnosis idiopathic interstitial pneumonias emerging data suggest increasing role transbronchial cryobiopsy tbc dpld evaluation describe experience tbc patients dpld methods retrospectively reviewed medical records patients radiographic features dpld underwent tbc mayo clinic rochester minnesota june september results seventy four patients women mean age years included mean maximal diameter samples range themedian number samples per procedure three range one seven diagnostic yield specimens frequent histopathologic patterns granulomatous inflammation patients organizing pneumonia patients resulting final diagnoses hypersensitivity pneumonitis six patients cryptogenic six patients connective tissue disease associated three patients drug toxicity three patients infection related two patients sarcoidosis two patients aspiration one patient histopathologic patterns included respiratory bronchiolitis three patients acute fibrinous organizing pneumonia two patients desquamative interstitial pneumonia patient diffuse alveolar damage one patient pulmonary alveolar proteinosis one patient amyloidosis one patient eosinophilic pneumonia one patient necrotizing vasculitis one patient bronchiolitis food particles one patient malignancy three patients pneumothorax developed one patient bleeding occurred patients conclusions single center cohort demonstrated diagnostic yield tbc rates pneumothorax bleeding respectively optimal use tbc needs determined
ever increasing human dependency internet performing various activities banking shopping transferring money equally exists need safe secure transactions need automatically translates requirement increased network security better fast encryption algorithms paper addresses issue introducing novel methodology utilizing aes method encryption also enhances help visual cryptography complete algorithm designed developed using matlab software paper also discusses hardware approach deploying algorithm elaborates area speed power efficient design spartan xilinx fpga platform
gene therapy one recent approaches treatment hepatocellular carcinoma hcc development vector vehicle selectively efficiently deliver gene target cells minimal toxicity urgent demand present study phosphatase tensin homolog pten tumor necrosis factor tnf related apoptosis inducing ligand trail genes loaded zein nanoparticles znps formulated pten trail loaded znps tested vitro vivo potential antitumor efficacy using liver tumor cells hepg hcc induced rats animal model also mrna expression vgef mmp carried markers apoptosis angiogenesis metastasis animal liver tissues results study showed pten trail loaded znps proved anti proliferative activity hepg cell lines values respectively vivo assay confirmed decrease mrna expression vegf mmp increased expression level liver tissues treated animals therefore authors introduced new integration gene therapy nanotechnology form pten trail loaded znps proved potential used gene therapy treatment hcc
objective borderline personality disorder bpd includes heterogeneous constellation symptoms operationalized categorical criteria field personality disorder research moves emphasize dimensional traits operationalization important delineate continuity dsm diagnostic statistical manual mental disorders fifth edition dsm categorical criteria bpd trait dimensions dsm section iii date study attempted validation methods examined associations categorical dsm dsm criteria bpd trait dimensions alternative dsm model pds consecutively recruited psychiatric outpatients female age mean investigated means bivariate correlations followed multiple logistic regression analysis results categorical bpd criteria associated conceptually related dsm section iii traits except criterion chronic feelings emptiness consistent proposed traits criteria bpd dsm section iii found emotional lability anxiousness separation insecurity depressivity impulsivity risk taking hostility capture conceptually coherent bpd categorical criteria suspiciousness also strongly associated bpd criteria domain level applied negative affectivity disinhibition psychoticism notably emotional lability impulsivity suspiciousness emerged unique predictors bpd conclusions addition proposed bpd traits criteria suspiciousness features psychoticism also augment bpd features provided findings replicated forthcoming research modified traits operationalization bpd warranted
aim study assess percentage users frequency use number cosmetic products consumed home french population evaluation performed adult child baby consumers pregnant women also taken account work products cosmetics including general hygiene skin care hair care hair styling make fragrances solar shaving depilatory products studied strengths study separation data sex age groups consideration priori risk subpopulations consideration large number cosmetic products current consumption data could useful safety assessors safety agencies order protect general population risk subpopulations elsevier ltd rights reserved
paper fourth order variable coefficient nonlinear schrodinger equation studied might describe one dimensional continuum anisotropic heisenberg ferromagnetic spin chain octuple dipole interaction alpha helical protein higher order excitations interactions continuum approximation aid auxiliary function derive bilinear forms corresponding constraints variable coefficients via symbolic computation obtain lax pair infinitely many conservation laws one two three soliton solutions discuss influence variable coefficients solitons different choices variable coefficients obtain parabolic cubic periodic solitons respectively analyse head overtaking interactions among two three solitons interactions bound state single soliton displayed different choices variable coefficients also derive quasi periodic formulae three cases bound states elsevier rights reserved
background individual dispositions previously associated increased risk depressive symptoms direction association found sometimes reciprocal examined whether temperament traits associated depressive symptoms whether depressive symptoms contribute changes temperament methods participants population based young finns study temperament assessed finnish version formal characteristics behavior temperament inventory depressive symptoms assessed modified bdi mbdi bdi results higher perseveration emotional reactivity associated higher level depressive symptoms higher endurance associated lower level depressive symptoms associations independent several potential confounders baseline depressive symptoms results cross lagged structural equation modeling showed associations temperament depressive symptoms reciprocal briskness endurance activity decreased risk depressive symptoms depressive symptoms decreased level characteristics perseveration emotional reactivity depressive symptoms reinforced time limitations depressive symptoms scales used meant measuring clinically diagnosed depression relationships temperament traits depressive symptoms strong enough provide clinical basis guiding treatment conclusions lower perseveration lower emotional reactivity higher endurance seem health protective temperament characteristics reduce risk depressive symptoms reciprocal associations temperament depressive symptoms imply mutual health protective health declining effects clinical relevance study enhancing positive loops self concept supporting individual stress management might helpful prevention depressive symptoms elsevier rights reserved
restoring hydrologic connectivity channels floodplains common practice stream river restoration floodplain hydrology hydrogeology impact stream hydraulics ecology biogeochemical processing pollutant removal yet rigorous field evaluations surface water groundwater exchange within floodplains overbank floods rare conducted five sets experimental floods mimic floodplain reconnection pumping stream water onto existing floodplain swale floods conducted throughout year capture seasonal variation involved two replicate floods successive days test effect varying antecedent moisture water levels specific conductance measured surface water soil groundwater within floodplain along surface flow floodplain vegetation density varied seasonally controlled volume surface water storage floodplain contrast antecedent moisture conditions controlled storage water floodplain soils drier antecedent moisture conditions leading increased subsurface storage slower flood wave propagation across floodplain surface site experienced spatial heterogeneity vertical connectivity surface water groundwater across floodplain surface propagation hydrostatic pressure preferential flow bulk darcy flow mechanisms may occurred five floods vertical connectivity also increased time suggesting higher frequency floodplain inundation may increase surface water groundwater exchange across floodplain surface understanding variability floodplain impacts water quality noted literature likely requires better accounting seasonal variations floodplain vegetation antecedent moisture well heterogeneous exchange flow mechanisms copyright john wiley sons ltd
ferguson meta analysis assessed important controversial topic children mental health video games response concerns raised researchers appropriateness meta analytical methods used ferguson decided reanalyze data discuss two major misconceptions meta analysis argue partial correlations meta analyzed instead zero order bivariate correlations predictors included partial correlation represent similar construct also discuss fallacy conventional meta analytical model assumes studies effect sizes came according random effect construct used analysis replication results using partial correlations standardized valid reliable outcomes improved meta analytical model assume random effect mechanism data generation confirmed main results ferguson meta analysis significant yet small effect aggressive behavior exposure general violent video games small effect seen reduced prosocial behavior general video game exposure category
background prevention acute treatment chronic cluster headache preva study attack frequency reductions baseline significantly pronounced non invasive vagus nerve stimulation plus standard care nvns soc soc alone given intensely painful frequent nature chronic cluster headache attacks additional patient centric outcomes including time level therapeutic response evaluated post hoc analysis preva study findings week baseline phase patients chronic cluster headache entered week randomised phase receive nvns soc soc alone patients continued week extension phase received nvns soc compared soc alone nvns soc led significantly lower mean weekly attack frequency week randomised phase attack frequency remained significantly lower nvns soc group week extension phase baseline response rate nvns soc soc alone conclusions prophylactic nvns led rapid significant sustained reductions chronic cluster headache attack frequency within weeks addition soc associated significantly higher response rates soc alone rapid decrease weekly attack frequency justifies week trial period identify responders nvns high degree confidence among patients chronic cluster headache
purpose reviewmetals play major roles children health associated negative health outcomes via deficiency overload toxicity constantly evolving analytical technology provide new insight metal metabolism exposure biology intertwined range biological matrices recent findingsexposure occur prenatally many metals cross placental barrier placenta permeable many metal species tightly regulated transporters others limited capacity detoxification postbirth metal exposure continues exert long term health effects ranging exposure exogenous heavy metals lead overload otherwise essential metals including manganese increasing evidence supports existence critical developmental windows susceptibility toxicants nutritional deficiencies highest elemental imaging technology provides microspatial information metal uptake retention across tissue architecture provides important insights exposure biologic response summaryimaging spatial distribution elements essential toxic provides information bulk measures including cell specific distributions timing exposure
task epitope discovery vaccine design increasingly reliant bioinformatics analytic tools access depositories curated data relevant immune reactions specific pathogens immune epitope database analysis resource iedb indeed created assist biomedical researchers development new vaccines diagnostics therapeutics analysis resource freely available researchers provides access variety epitope analysis prediction tools tools include validated benchmarked methods predict mhc class class binding predictions tools combined tools predicting antigen processing tcr recognition cell epitope prediction addition resource contains variety secondary analysis tools allow researcher calculate epitope conservation population coverage relevant analytic variables researcher involved vaccine design epitope discovery also interested accessing experimental published data relevant specific indication interest database component iedb contains vast amount experimentally derived epitope data queried flexible user interface iedb linked pathogen specific immunological database resources
drawing norm activation theory study explores link tourists perceptions negative impacts tourism perceived responsibility proposed theoretical framework examined verified exploratory confirmatory research processes self administered questionnaires collected two unesco world natural heritage sites china findings research suggest tourists perceptions negative impacts tourism positively affect ascription responsibility positively influences tourists perceptions responsibility nevertheless accessibility information tourism impacts far enough foster tourists sense responsibility important promotion responsible behaviours several practical implications provided address tourists sense responsibility including enhancing tourists awareness negative tourism impacts increasing availability accessibility information tourism impacts recommending behaviours tourists make positive difference destinations
wake therapy reduce depressive symptoms within days response rates high sustain effect often combined light therapy studies focussed factors related patients adherence regime none used qualitative methods examine experience combined interventions therefore aim present study illuminate patients experiences wake light therapy factors related adherence thirteen inpatients depression included participated intervention consisting three wake therapies first week min daily light treatment entire weeks ongoing psychoeducation regarding good sleep hygiene patients kept diary individual semistructured interviews conducted data analysed using qualitative content analysis participants overall experience treatment positive experienced remarkable rapid antidepressant effect whereas others described long term benefits improved sleep diurnal rhythm yet recovery fragile patients cautiously optimistic social support important maintaining motivation stay awake receive daily light therapy overall participants found treatment worthwhile would recommend others depression study revealed lack knowledge among participants connection regular sleep patterns depression conclusion study provides insight patients experiences knowledge contribute guidelines future adherence promoting organization wake light therapy
work develops two dimensional hydro morphological model used simulate river hydraulics morphology various vegetation covers model system consists five modules including hydrodynamic model sediment transport model vegetation model bank failure model bed deformation model secondary flow effects incorporated additional dispersion terms core components model system solve full shallow water equations coupled non equilibrium sediment transport model new integrated model system validated number laboratory scale test cases applied natural river satisfactory simulation results confirm model capability reproducing stream hydraulics channel morphological changes vegetation several hypothetical simulations indicate model used predict flooding morphological evolution vegetation also assess river restoration involving vegetation elsevier ltd rights reserved
introduce framework simulating mesoscale self assembly block copolymers arbitrary confined geometries subject neumann boundary conditions employ hybrid finite difference volume approach discretize mean field equations irregular domain represented implicitly level set function numerical treatment neumann boundary conditions sharp avoids artificial smearing irregular domain boundary strategy enables study self assembly confined domains enables computation physically meaningful quantities domain interface addition employ adaptive grids encoded quad trees parallel automatically refine grid statistical fields vary rapidly well boundary confined domain approach results significant reduction number degrees freedom makes simulations arbitrary domains using effective boundary conditions computationally efficient terms speed memory requirement finally case regular periodic domains pseudospectral approaches superior finite differences terms cpu time accuracy use adaptive strategy store chain propagators reducing memory footprint without loss accuracy computed physical observables elsevier inc rights reserved
main bearing structure suspension bridges stability anchorage foundation important north anchor foundation run yang bridge stabilities sliding overturning analyzed computation results three dimension finite element simulation models effect soil resistance behind pit stabilities analyzed suppose values overload cable tension increase proportionally studying changes deformation stress anchor foundation basement resistance foundation stabilities sliding overturning different overload coefficients overload safety obtained anchor foundation based numerical computational results stability overload analysis beneficial results obtained stability analysis anchorage foundation suspension bridge
selection floral traits hermaphroditic plants determined male female reproductive success however predictions regarding floral trait mating system evolution often based solely female fitness selection viamale fitness potential affect outcomes floral evolution study used paternity analysis assess individual selfing rates selection floral traits via male female fitness experimental population clarkia xantiana pollen limitation seed set strong detected selection female male fitness reinforcing noninterfering patterns selection two sex functions female fitness selection favored reduced herkogamy protandry traits promote increased autonomous selfing male fitness selection petal area disruptive higher trait values conferring greater pollinator attraction outcross siring success smaller trait values leading higher selfed siring success combining female male fitness selection petal area protandry disruptive intermediate phenotypes less successful males females finally functional relationships among male female fertility components indicated selfing resulted seed discounting pollen discounting functional relationships evolutionarily stable selfing rate intermediate predominantly selfing outcrossing depending segregating load deleterious mutations
use planning management tools water management urban environments promising area paper focuses description two indicators water intensity purchase wip potential water self sufficiency pwss rainwater harvesting expanding sector retail parks wip measures water consumed per average customer purchase whereas pwss quantifies potential capacity system satisfy water demand rainwater tools checked two case studies spain brazil results show wip litres respectively measures efficiency water use water demand mainly low quality met potable water supply network stormwater runoff lost sewage pwss results spain brazil indicate could satisfy needs rainwater even surplus water combined use wip pwss useful planning design evaluation monitoring
article describes improved magnetic shape memory alloy actuator msma actuator test stand previously made stand pointed weak sides first stand improvements new one several quasi static measurements performed results compared measurement stands msma actuator characterises significant hysteresis loop improved test stand allowed reduce width increased rigidity stand excluded influence stand deformations results described stand resulted similar improved measurements msma actuator characteristics also proved correctness previous results
server side socialbot detection approaches identify malicious accounts spams online social networks however detect socialbot processes residing user hosts control accounts therefore new approaches needed detect socialbots hosts fundamental design host side detecting approaches gain insight behaviors socialbots host article analyzed series representative socialbots depth summarized typical features socialbot behaviors proposed new approach defense socialbots end host contributions article threefold analysis approach used reference analyzing new socialbots future provide several behavior features socialbots hosts including network flow socialbots communicate botmasters online social network system calls via socialbots conduct activity process information socialbots running hosts features used someone design approaches identifying socialbots host proposed detection approach effectively distinguish socialbot benign application end hosts
study association heavy metals water cyprinids sampled yeilrmak river stretch frequently exposed pollutant sources sugar production factory turhal solid wastes dump area talciftlik explored oxidative effects heavy metals cyprinids evaluated analyzing liver enzymes namely superoxide dismutase sod catalase cat malondialdehyde mda cortisol heavy metal concentrations fish water collected three different locations along river summer winter turhal talciftlik gumenek determined inductively coupled plasma atomic emission spectroscopy icp aes water fish liver heavy metal concentrations exhibited increasing trends upstream gumenek downstream turhal water liver samples collected summer higher heavy metal concentrations obtained winter mean heavy metal concentrations increased gumenek turhal liver heavy metal concentrations higher water exhibited almost increasing trend gumenek turhal positive relationships liver water heavy metal concentrations especially cadmium lead obtained among liver enzymes mda followed increasing trend gumenek turhal obtained heavy metals hand cat sod contrary spatial pattern change heavy metals mda although values heavy metals mda talciftlik two locations fish inhabiting locality significantly higher values cortisol indication stress causing factors fish
incidence types injuries investigated among nigerian soccer players selected clubs stratified random technique basis somatotypes purpose identify physique types prone common injuries soccer groups week duration intensive training total injuries sprains strains bruises cuts dislocations fractures concussion recorded sustained players participated week period vigorous daily training study found meso ectomorphs mesomorphs sustained injuries ectomorphs ectomesomorphs injured study concluded soccer players whose somatotypes range meso ectomorphic mesomorphic builds less prone injuries fragile linear counterparts recommended soccer players preselected basis somatotypes cases mesomorphic meso ectomorphic types finally considered proposed match referees endeavour enforce soccer rules escbew prejudice prevent frustration aggression reactions good causes injuries players
objective estimate compare effectiveness levonorgestrel yuzpe regimens hormonal emergency contraception routine clinical practice methods retrospective population based study included women accessed emergency contraceptives immediate use prescribed community pharmacists british columbia canada december december linked administrative healthcare data used discern timings menses unprotected intercourse pregnancy related health services panel experts evaluated compatibility observed pregnancies timing events two regimens compared statistical adjustments potential confounding results among women cohort received levonorgestrel yuzpe regimen compatible pregnancies levonorgestrel group yuzpe group estimated odds ratio levonorgestrel compared yuzpe regimen adjusting potential confounders confidence interval expected pregnancy rate approximately relative absolute risk reductions respectively levonorgestrel yuzpe regimen conclusion levonorgestrel regimen effective yuzpe regimen routine use data suggest regimens less effective observed randomized trials international federation gynecology obstetrics published elsevier ireland ltd
stress plays key role addiction etiology relapse rodent models posit following repeated periods alcohol drug intoxication compensatory allostatic changes occur central nervous system cns circuits involved behavioral emotional response stressors examine predicted manifestation neuroadaptation recently abstinent alcohol dependent humans participants completed translational laboratory task uses startle potentiation unpredictable predictable stressors implicated putative cns mechanisms mediate neuroadaptation alcohol dependent participants displayed significantly greater startle potentiation unpredictable predictable stressors relative nonalcoholic controls size effect covaried alcoholrelated problems degree withdrawal syndrome supports rodent model thesis sensitized stress response abstinent alcoholics however effect could also represent premorbid risk mark severe comorbid psychopathology regardless pharmacotherapy psychological interventions may target unpredictable stressor response reduce stress induced relapse
corrosion inhibition efficiency performance biopolymers iota carrageenan inulin inu mild steel hso solution evaluated using weight loss potentiodynamic polarization electrochemical impedance spectroscopy eis techniques inhibition efficiency inhibitors increased increase concentration thermodynamic parameters delta ads activation parameters delta degrees delta degrees calculated investigate mechanism inhibition polarization studies revealed studied inhibitors mixed type scanning electron microscope sem energy dispersive ray spectroscopic edx atomic force microscopy afm studies used characterize surface morphology inhibited uninhibited mild steel elsevier rights reserved
electric vehicles evs specifically battery evs bevs offer significant energy emission savings internal combustion engine vehicles norway long history research government incentives bevs bev market norway allows fully examine consumers bev choices influenced car specifications prices government incentives public bus lanes access toll waiver charging stations random coefficient discrete choice model referred blp model applied understand choices heterogeneous personal consumers business buyers study instantiated entire sales data norway well set demographics municipality level results suggest significant positive effects bev technology improvement space toll waiver charging station density demand personal consumers business buyers however effects business buyers may generally less pronounced personal consumers interestingly bus lanes access demonstrates negative impact personal consumers possibly due consumers concern regarding bus lane congestion addition preferences bev price vary statistically among consumers different income levels compared bev technology development demographical features municipal incentives may generally less impacts market shares within bev market elsevier ltd rights reserved
microcatchment technique collecting storing conserving local surface runoff order grow trees shrubs system runoff water generated plot stored soil runoff events trees shrubs may utilize water next dry season microcatchments relatively small runoff generation areas dozens hundreds cheap simple implement collection area usually small depression located nearby runoff generating area one trees shrubs may planted due short overland flow path runoff generation efficient even short low intensity storms may generate runoff drawback however due small size generating area small volumes water conveyed storage plots another drawback susceptibility augmented water evaporation main objective present research presented hereafter estimate effect depth depression efficiency water conservation soil profile present study storage plots circular pits effect depth evaporative losses water distribution studied results clearly show depth pit significantly affects evaporative water losses losses separately computed soil cylinder whose upper surface bottom pit surrounding shell differences treatments evident losses inner cylinder significant differences water losses however observed surrounding shell shallow pits losing much six times deeper pits elsevier ltd rights reserved
insertion propagation problem class view update problem relational databases given source database monotone relational algebraic query view generated query insertion propagation problem find set delta tuples whose insertion add given tuples delta view via without producing side effect view paper consider restricted version insertion propagation problem vsef aim find delta view side effect free also without introducing inconsistency respect predefined functional dependencies study data combined complexity vsef single group insertion interestingly problem ranges ptime sigma complete queries different classes either complexity aspect show restricted version harder get optimal solution contrary counterpart deletion study restricted version insertion propagation problem generalize computational issues involved data lineage process databases updated view insertion
article analyses novels luz sombra ana roque las memorias mama blanca teresa parra focusing friendship female characters texts friendships women important thematical well structural terms one hand constitute parallel alternative plot one centered heterosexual love pressure women marry hand novels comprised letters exchanged protagonists luz sombra built basis collaborative artistic creations las memorias mama blanca propose narratives represent possibility building alternative spaces trajectories women depend largely upon building bonds solidarity intimacy writing letters reading together sharing dialogues reflections play main role configuration female subjectivities less bound gender roles stereotypes
essay examines school leadership experiences infant school head teacher birmingham england second world war drawing letters dorothy walker essay offers insights school leadership wartime deprivations impact international war home front head teacher dorothy walker challenge youngest one women head teachers birmingham dorothy walker struggled traditional masculine hierarchy local educational system traditional social familial gender roles dorothy walker also battled traditional educational school culture promoted progressive educational practices three challenges war gender relations progressivism referred dorothy wars battles faced woman school leader birmingham early years second world war
objective determine impact race insurance use minimally invasive mis compared open techniques rectal cancer united states background race socioeconomic status implicated disparities rectal cancer treatment methods adults undergoing mis laparoscopic robotic open rectal resections stage iii rectal adenocarcinoma included national cancer database multivariate analyses employed examine adjusted association race insurance use mis versus open surgery results among patients underwent mis open surgery overall white black asian factors associated use open versus mis black race medicare medicaid insurance lack insurance however adjustment patient demographic clinical treatment characteristics black race associated use mis versus open surgery odds ratio compared privately insured patients uninsured patients medicare medicaid less likely receive minimally invasive resections lack insurance significantly associated less use mis black white patients however among uninsured patients black race associated lower use mis conclusions insurance status race associated utilization minimally invasive techniques oncologic rectal resections due short term benefits cost effectiveness minimally invasive techniques hospitals may need improve access techniques especially uninsured patients
gynecologist plastic surgeons pioneered application lasers medicine surgery almost decades ago initially used treat cervical vaginal pathologies ever since energy based devices deployed treat pelvic pathologies improve fertility recent technological developments triggered unprecedented wave publications assessing efficacy fractional laser radiofrequency vaginal wall reversing natural aging processes studies shown certain degree thermal energy deposited vaginal wall stimulates proliferation glycogen enriched epithelium neovascularization collagen formation lamina propria improves natural lubrication control urination review aimed review data guide future research unique assembly experts around globe compiled edited manuscript based thorough literature review personal experience wiley periodicals inc
understanding continuous human actions non trivial important problem computer vision although exists large corpus work recognition action sequences approaches suffer problems relating vast variations motions action combinations scene contexts paper introduce novel method semantic segmentation recognition long complex manipulation action tasks preparing breakfast making sandwich represent manipulations recently introduced semantic event chain sec concept captures underlying spatiotemporal structure action invariant motion velocity scene context solely based spatiotemporal interactions manipulated objects hands extracted sec framework automatically parses individual manipulation streams performed either sequentially concurrently using event chains method extracts basic primitive elements parsed manipulation without requiring prior object knowledge proposed framework also extract object like scene entities exhibit role semantically similar manipulations conduct extensive experiments various recent datasets validate robustness framework
indian himalayan region ihr landslide driven hazards intensified past several decades primarily caused occurrence heavy extreme rainfall however little attention given determining cause events triggered pre post indian summer monsoon ism seasons present research detailed geological meteorological remote sensing investigations carried extreme rainfall landslide event occurred sadal village udhampur district jammu kashmir himalaya september toward receding phase ism month september unusual rainfall event similar rainfall took place jammu kashmir himalaya contrast normal rainfall occurrence geological investigations suggest planar weakness affected region caused bedding planes consist alternate sequence hard compact sandstone weak claystone extreme rainfall event sadal village completely buried rock slides failure occurred along planar weakness dips toward valley slope rainfall data analysis tropical rainfall measuring mission trmm preceding years homogeneous time series july september indicates years closely spaced clustering heavy rainfall events received heavy rainfalls withdrawal ism whereas heaviest rainfall received years onset ism study region suggests characteristic cyclicity exists extreme rainfall events however observe either toward onset ism retreat extreme rainfall facilitates landslides rockfall slope failures northwestern himalaya spatiotemporal distribution landslides caused extreme rainfall events suggests confinement toward windward side himalayan front elsevier rights reserved
deadly nevado del ruiz costly eyjafjallajokull eruptions last years glaciovolcanic considering great importance studies volcanic hazards global climate even astrobiology global distribution gladovolcanism insufficiently understood present assess three algorithms mapping monitoring predicting likely centers glaciovolcanic activity worldwide algorithm intersects buffer zones representing known holocene active volcanic centers existing datasets snow ice permafrost two detection algorithms rgga pzga simple spatial join operations computed randolph glacier inventory permafrost zonation index respectively third mdga algorithm run available years moda weekly snow cover product terra modis satellite radiometer shortcomings advantages three methods discussed including previously unreported blunders moda dataset comparison results leads effective approach integrating three methods show known holocene volcanic centers host glaciers areas permanent snow potentially interact permafrost mdga pzga rely human input rendering useful investigations change time intermediate step mdga involves estimating snow covered area every holocene volcanic center estimations updated weekly human intervention investigate feasibility automatic ice loss alert system consider three examples glaciovolcanism mdga weekly dataset also discuss potential use pzga model past future glaciovolcanism based global circulation model outputs combined three algorithms provide automated system understanding geographic temporal patterns global glaciovolcanism use hazard assessment search extreme microbiomes climate models implementation ice cover based volcano monitoring systems elsevier rights reserved
construction process cultivation model curriculum system materials engineering master degree candidate university science technology liaoning introduced paper exploration practice different aspects curriculum system cultivating model training plan revision contents integration discussed research
using elastic isolating objects scheme passive control efficiently control high frequency vibration however generally invalidates control low frequency vibration especially vibration control using smart material actuators utilized structural vibration control ability deliver large forces wide band responses precise relatively large displacement giant magnetostrictive actuator great potentials vibration especially low frequency vibration control research giant magnetostrictive actuator low frequency adaptive vibration control realized investigated order avoid quadric frequency effect magnetostriction realize control using linear harmonic signal permanent biased giant magnetostrictive actuator designed constructed meantime magnetostrictive adaptive control algorithm control system realized self tuning adaptive control method vibration control proposed comparison inverse feedforward pid control fit step response gma previous work research actuator low frequency adaptive vibration control finally experimentally verified proves giant magnetostrictive actuators may secure applications adaptive control low frequency vibration
paper presented phase loop controlling chain pass filters called delay locked loop analog signal processing used signal phase regulation cmos technology used design verification circuit according obtained results concluded possible obtain phase regulation wide frequency range khz mhz
background dearth research published literature substance use addiction middle east islamic countries study first explore whether biopsychosocial spiritual model addiction relevant addicted treatment population jordan islamic country methods qualitative study design using semi structured face face interviews conducted sample males addiction treatment sample drawn cohort patients treatment centre amman jordan already participated quantitative survey purposive sample selected ensure inclusion range characteristics might affect experience developing addiction consequences age marital status educational level interviews transcribed thematic analysis conducted using verbatim quotes illustrate themes themes mapped onto biopsychosocial spiritual model addiction results study found addiction associated range health physical psychological social spiritual factors unpleasant physical withdrawal effects psychological symptoms anxiety suicide attempts experienced breakdown marital family relations loss employment involvement crime neglect religious practices resulting social isolation conclusion study found despite differences emphasis biopsychosocial spiritual model addiction fit well particularly given relative importance religion islamic culture spirituality explored study spirituality versus religious practice culture recommended published elsevier ireland ltd
introduction middle school children involved sports sections exposed fatigue syndrome overtraining syndrome syndrome explored auto questionnaire fatigue questionnaire fatigue enfant sportif qfes moreover epidemiological studies sports injuries ages reveal peak years old children goal determine influence qfes score incidence sports injuries middle school athletes methods two hundred seventy six children aged years old involved fifteen middle school sports sections practicing average min per week eleven different sports enrolled december april pupil completed qfes injury questionnaire based consensus statement international federation football association fifa international rugby board irb results subjects injured previous two months higher qfes mean score compared non injured rate injuries increased qfes score qfes score increased body mass index bmi percentiles conclusion qfes could effective tool monitor prevent fatigue syndrome middle school athletes sufficient rest periods training plans weight management could prevent children fatigue sports injuries elsevier masson sas rights reserved
introduction irritable bowel syndrome ibs prevalent functional gastrointestinal disorder represents major cost healthcare services ibs patients represent one third ibs population currently treated antispasmodics loperamide bile acid sequestrants antidepressants alosetron rifaximin also available usa ramosetron japan korea thailand ondansetron label treatment areas covered article focuses eluxadoline novel pharmacological agent recently approved fda ema treatment patients ibs expert commentary efficacy safety eluxadoline treating bowel habit alterations pain short long term make drug welcome addition therapeutic alternatives ibs positioning ibs algorithm depend real world prevalence small risk sphincter oddi spasm mild pancreatitis
fukushima nuclear power plant accident caused widespread radiation contamination mothers young children risk negative emotional mental health consequences using data independent prefecture wide surveys pregnant women examined associations disaster related stressors maternal self confidence depressive symptoms two postal surveys conducted targeting women registered pregnancies fukushima prefecture proportions mothers lower self confidence child rearing depressive symptoms respectively adjusting maternal infant characteristics evacuation concern radiation significantly associated depressive symptoms lower maternal confidence although outcomes significantly associated mothers fukushima showed resilience parenting whereas experiences concerns aftermath nuclear disaster associated depressive symptoms
objectiveindividuals anorexia nervosa body dysmorphic disorder bdd exhibit distorted perception negative evaluations appearance however little known perceive others appearance whether conditions share perceptual distortions methodthirty participants bdd weight restored healthy comparison participants rated photographs others faces bodies attractiveness overweight underweight much photographs triggered thoughts appearance compared responses among groups stimulus type level detail spatial frequency resultscompared hcs bdd lower attractiveness ratings others bodies faces high detail low detail images rated bodies overweight triggered think appearance faces bodies symptom severity associated greater triggering thoughts appearance higher endorsement overweight ratings bodies bdd symptom severity associated greater triggering thoughts appearance bodies higher overweight ratings low detail images bdd triggered think facial appearance discussionan bdd show similar behavioral phenotypes negative appearance evaluations others faces bodies thoughts appearance triggered even images outside primary appearance concerns suggesting complex cross disorder body image phenotype previously assumed future treatment strategies may benefit addressing individuals evaluate others addition wiley periodicals inc int eat disord
paper method discrete element model dem simulation used investigate mechanical properties sic ceramic materials action pre stress using bonded particle model bpm several different numerical tests uct tpb senb tests sic ceramic established different pre stress values applied lateral surface ceramic specimen numerical simulation process tests carried least times different random number average mechanical properties results calculated showed existence pre stress significant effect mechanical properties materials enhance strength materials force action material machining process force action force crack initiation propagation limited
iodine deficiency induced thyroid hormone insufficient development leads impairments brain function learning memory marginal defined subtle insufficiency characterized low thyroxine levels whether marginal potentially adverse effects development hippocampus underlying mechanisms remain unclear thus present study established wistar rat models diet pregnancy lactation effects marginal long term potentiation ltp investigated hippocampal region study development dendritic spines pyramidal cells golgi cox staining conducted postnatal day activation rac signaling pathway essential dendritic spine development regulating actin cytoskeleton also investigated results showed marginal slightly reduced field excitatory postsynaptic potential epsp slope population spike amplitude besides density dendritic spines critical period rat postnatal development mildly decreased found significant change spine morphology marginal group also observed decreased activation rac signaling pathway pups subjected maternal marginal study may support hypothesis decreased induced marginal results slight impairments ltp leads mild damage dendritic spine development may due abnormal regulation rac signaling pathway cytoskeleton
paper focuses hamiltonian mathematical modeling dynamic characteristics multi hydro turbine governing systems sharing common penstock excitation stochastic shock load considering hydraulic coupling problem common penstock propose universal dynamic mathematical model multi hydro turbine governing system proposed model fitted theoretical framework generalized hamiltonian system utilizing method orthogonal decomposition dissipation energy produced energy energy supplied external sources derived hamiltonian model compared physical energy flow furthermore numerical experiments based real hydropower station demonstrate hamiltonian function describe accurately energy variation hydro turbine system transient process stable process moreover order deal randomness mutability electrical load introduce gaussian function jump function control signal pid controller analyze dynamic characteristics addition intensity shock load discussed system loses stability proposed approach used improving stability hydropower stations elsevier ltd rights reserved
three spectral collocation methods namely laguerre collocation laguerre gauss radau collocation lgrc mapped chebyshev collocation chc used order solve challenging systems boundary layer problems third second orders last two methods enable fourier type analysis mainly fast polynomial transformations used order improve process optimization scaling parameters generally second method mentioned produces best results unfortunately remain sub geometric respect accuracy however methods avoid domain truncation rather arbitrary shooting techniques challenging problems fluid mechanics including non newtonian fluids accurately solved
youth exposed large amounts violence real life media may lead desensitization given evidence curvilinear associations exposure violence emotional distress examined linear curvilinear associations exposure real life movie violence ptsd symptoms empathy physiological arousal well emotional physiological reactivity movie violence college students mean age reported exposure real life televised violence ptsd symptoms empathy students randomly assigned view series violent nonviolent high action movie scenes providing ratings emotional distress clip blood pressure measured rest video viewing results showed increasing exposure real life violence youth reported ptsd symptoms greater identification fictional characters cognitive emotional empathy increased low medium levels exposure violence declined higher levels males exposure higher levels real life violence associated diminishing increasing emotional distress viewing violent videos exposure televised violence generally unrelated emotional functioning however medium levels exposure movie violence experienced lower elevations blood pressure viewing violent videos compared low exposure higher levels exposure evidenced rapid increase blood pressure quickly declined time results point diminished empathy reduced emotional reactivity violence key aspects desensitization real life violence limited evidence physiological desensitization movie violence among exposed high levels televised violence
paper application interpolation damage detection method numerical model suspension bridge instrumented network micro electro mechanical system sensors presented method present formulation belongs level damage identification method identify presence location damage responses recorded structure seismic damaging event application method require knowledge modal properties structure numerical model emphasis placed herein influence recorded signals noise reliability results given interpolation damage detection method response suspension bridge seismic excitation computed numerical model artificially corrupted random noise characteristic two families micro electro mechanical system accelerometers reliability results checked different damage scenarios
paper presents design implementation personal intelligent home media center primary goal increase quality life use ambient intelligence smart homes solution presented uses client server architecture network attached storage storing multimedia contents sensors used identify person presence ambient intelligence techniques recommend suitable multimedia content end users major advantages personal intelligent home media center speed intelligence inexpensive components scalability implementation done within one home media center evaluation purposes
intestinal microbiota might contribute enteropathy associated use nonsteroidal anti inflammatory drugs nsaids human studies association performed placebo controlled study determine whether delayed release antibiotic formulation rifaximin extended intestinal release eir prevents development intestinal lesions subjects taking daily nsaids sixty healthy volunteers median age female given nsaid diclofenac twice daily plus omeprazole daily either rifaximin eir placebo twice daily days subjects assessed videocapsule endoscopy baseline weeks treatment primary end point proportion subjects developing least small bowel mucosal break week secondary end points change mean number mucosal lesions number subjects large erosions ulcers days exposure detected mucosal breaks subjects given rifaximin subjects given placebo post hoc sensitivity analysis none subjects rifaximin group developed large lesions compared subjects placebo group findings indicate intestinal bacteria contribute development nsaidassociated enteropathy human beings
background porphyromonas gingivalis one etiological agents initiation combined periodontal endodontic perio endo lesions successful treatment perio endo lesions photo activated disinfection pad novel therapeutic approach depends selection appropriate target site specific photosensitizer wavelength light since fimbrillin fima important pathogenic agent gingivalis evaluated target site pad toluidine blue tbo materials methods evaluated potential fima using number bioinformatic tools computer simulation molecular modeling silico analysis done predict hierarchical nature structure topology backbone physicochemical properties functional characterization fima results predicted structure fima exhibited anionic protein negative charge random coil dominates secondary structures located outside cell three motifs seven ligand binding site residues one active site residue site interaction cationic tbo conclusion based results study cationic tbo tends interact fima pad major target increase efficiency treatment perio endo lesions elsevier rights reserved
descriptive epidemiologic survey traumatic overuse injuries occurred groups male elite road cyclists based retrospective clinical interviews physical examinations historical group consisted professional road cyclists surveyed contemporary group included elite racers still active reporting injuries injury cyclist ratio historical group still active traumatic injuries increased historical contemporary severe traumatic lesions decreased historical group contemporary group patellofemoral pain decreased historical contemporary muscle injuries substantially increased historical racers rates risk traumatic injury per year per cyclist per training competition figures increased respectively contemporary group summary contemporary professional road cyclists exposed double risk traumatic injuries competing early however lesions less severity overuse injuries completely different clinical pattern currently active cyclist exhibiting muscle injuries less tendinous lesions
emergence new professions novel approaches work contribute newer causes occupational stress current study focuses one emergent group namely software development professionals attempt made examine role self efficacy collective efficacy perception control study occupational stress data collected software development professionals india variables self efficacy collective efficacy perception control using multiple moderated regression revealed variables moderate negative consequences stress respect work exhaustion organizational commitment intent turnover respect job satisfaction results indicate self efficacy collective efficacy strengthened order mitigate negative consequences stress knowledge pertaining causes stress empower individuals organizations plan effective stress management interventions
introduction ankylosing spondylitis morbus bechterew chronic inflammatory rheumatoid disease temporomandibular joint tmj dysfunction involved cases correlated severity extension even though caused tmj ankylosis exceptional one high index suspicion tmj ankylosis early detection extremely serious disabling condition causes problems mastication swallowing digestion speech appearance poor oral hygiene heavy caries case report year old male patient sought medical attention department periodontology oral medicine clinic dentistry military medical academy belgrade serbia chief complaint pain area upper left canine presence limited mouth opening treatment plan consisted upper left canine management rehabilitation remaining teeth frontal premolar region upper lower jaw even though molar region needed treated unfortunately treatment plan ankylosis tmj made treatment impossible conclusion patients caused tmj ankylosis considered diagnostic challenge routine dentistry accent given early diagnosis multidisciplinary approach treatment patients towards favorable disease course outcome
vagal link gastrointestinal tract central nervous system cns numerous vital functions maintaining homeostasis regulation energy balance one attracting attention due potential exploiting peripheral hormonal targets treatments conditions obesity physiologically system well tuned demonstrated effective regulation local function promoting terminating food intake neural connection represents susceptible pathway disruption various disease states numerous studies revealed obesity particularly associated array modifications vagal afferent function changes expression signaling molecules altered activation mechanics general changes vagal afferent function obesity promote food intake instead desirable reduction food intake essential gain comprehensive understanding mechanisms responsible detrimental effects establish effective pharmacotherapies lifestyle strategies treatment obesity maintenance weight loss
neuroactive steroids alpha alpha hydroxypregnan one alpha alpha thp allopregnanolone enhance gamma aminobutyric acid gaba ergic effects ethanol modulate excessive drinking rodents moreover chronic ethanol consumption reduces alpha alpha thp levels human plasma rat hippocampus mouse limbic regions explored relationship alpha alpha thp levels limbic brain areas voluntary ethanol consumption cynomolgus monkey following daily self administration ethanol months examined relationship hypothalamic pituitary adrenal hpa axis function prior ethanol exposure monkeys subjected scheduled induction ethanol consumption followed free access ethanol water day months immunohistochemistry performed using anti alpha alpha thp antibody prolonged voluntary drinking resulted individual differences ethanol consumption ranged day months prolonged ethanol consumption reduced cellular alpha alpha thp immunoreactivity percent lateral amygdala percent basolateral amygdala effect ethanol pronounced heavy drinkers consumed percent days consequently alpha alpha thp immunoreactivity lateral basolateral amygdala inversely correlated average daily ethanol intake spearman respectively however effect ethanol correlation drinking alpha alpha thp immunoreactivity observed basomedial amygdala alpha alpha thp immunoreactivity following ethanol exposure also correlated hpa axis function prior ethanol exposure data indicate voluntary ethanol drinking reduces amygdala levels alpha alpha thp non human primates amygdala alpha alpha thp levels may linked hpa axis function
study found people suffer seasonal affective disorder sad displayed financial risk aversion varied across seasons function seasonally changing affect sad sufferers significantly stronger preferences safe choices winter non sad sufferers differ non sad sufferers summer effect sad risk aversion winter mediated depression
impulsivity core feature antisocial personality disorder aspd associated abnormal brain function neurochemical alterations ventral striatum key region neural circuitry mediating impulsive behavior low monoamine oxidase mao level shown specific relationship impulsivity aspd currently unknown whether phenotypic mao markers influence brain function aspd investigated mao level functional connectivity two seed regions superior inferior vss vsi nineteen impulsive aspd males underwent harmine positron emission tomography scanning measure mao index mao density resting state functional magnetic resonance imaging assessed bilateral seed regions vsi vss subjects also completed self report impulsivity measures results revealed functional coupling vss bilateral dorsomedial prefrontal cortex dmpfc correlated mao functional coupling vsi right hippocampus anti correlated mao additionally vss dmpfc negatively correlated neo personality inventory revised impulsivity vsi hippocampus barratt impulsiveness scale motor impulsiveness preliminary results highlight association mao level striatal regions linked impulsive behavior aspd suggest phenotype based brain markers aspd relevance understanding brain function elsevier ecnp rights reserved
piezoelectric thin films offer number advantages various applications high energy density harvesters wide dynamic range high sensitivity sensors well large displacement low power consumption actuators review covers available material forms applications piezoelectric thin films lead zirconate titanate pzt based thin films lead free piezoelectric thin films piezopolymer films cellulose based electroactive paper eapap many thin films used electromechanical transduction electromechanical properties performances piezoelectric films compared suitability particular applications reported key ideas piezoelectric thin films reviewed discussed sensory actuation systems energy harvesting medical acoustic transducers last section insight future outlook possibilities thin film based devices integration real world applications presented
drug resistance consequence modern medicines work drugs exert pressure cells causes death evolution resistance indeed highly specific drugs rendered ineffective single dna mutation study apply drug methotrexate widely used cancer rheumatoid arthritis perform evolution experiments baker yeast ask different ways cells become drug resistant conserved nature biological pathways yeast man results inform mechanism may operate render human cells resistant treatment exposure cells small molecules drug therapies imposes strong selective pressure result cells rapidly acquire mutations order survive include resistant variants drug target well modulate drug transport detoxification systematically explore cells acquire drug resistance unbiased manner rapid cost effective approaches required methotrexate one first rationally designed anticancer drugs served prototypic example acquired resistance known methotrexate resistance mechanisms include mutations increase expression dihydrofolate reductase dhfr target well maintain function yet reduce drug binding affinity recent evidence suggests target independent epistatic mutations also result resistance methotrexate currently however relative contribution unlinked resistance mutations well understood address issue took advantage saccharomyces cerevisiae model eukaryotic system combined whole genome sequencing rapid screening methodology allowed identification causative mutations modulate resistance methotrexate found recurrent missense mutation sec orthologous human copg confirmed novo methotrexate resistant strains sec allele behaves recessive gain function allele conferring methotrexate resistance abrogated presence wild type copy sec observations indicate secp copi transport complex previously uncharacterized roles modulating methotrexate stress
objective cognitive challenges prominent features individuals diagnosed schizophrenia impairing occupational social economic functioning challenges predictive social work outcomes cognitive remediation shown effective improving cognitive social functions however cognitive remediation produce improvement participants investigated demographic neurocognitive psychopathological predictors associated improvement following cognitive remediation interventions service recipients severe mental illnesses method one hundred thirty seven adult participants diagnosis schizophrenia schizoaffective disorder bipolar disorder according diagnostic statistical manual mental disorders text rev enrolled week cognitive remediation programs assessments demographic illness variables together baseline end point assessment psychopathology positive negative syndrome scale panss neurocognition measurement treatment research improve cognition schizophrenia matrics consensus cognitive battery mcbb social functions personal social performance scale psp conducted change cognitive domains calculated using reliable change index logistic regression analysis used assess predictors cognitive improvement intervention results sixty two percent participants improved least mccb domains higher baseline speed processing attention vigilance working memory predicted positive response cognitive remediation younger age higher education level shorter length stay lower panss negative disorganized factors additional predictors conclusions implications practice results indicate clinical usefulness cognitive remediation identified pattern clinical cognitive predictors good response intervention identification predictive factors clinicians may enhance outcome aid development individualized rehabilitative cognitive remediation treatment plans
schematic method increasing radiation hardness bipolar operational amplifiers aset effects presented method based use improved current mirror modified input stage circuit
stick balancing fingertip complex voluntary motor task requires stabilization unstable system seated expert stick balancers time delay shortest stick balanced approximate degrees dead zone estimation vertical displacement angle saggital plane observations motivate switching type pendulum cart model balance control uses internal model compensate time delay predicting sensory consequences stick movements numerical simulations using semi discretization method suggest feedback gains tuned near edge stability choices feedback gains cost function takes account position fingertip corrective forces minimized thus expert stick balancers optimize control combination quick manoeuvrability minimum energy expenditures
paper describes method increasing contact fatigue strength materials intended application production gears investigations carried cralmo grade steel closest equivalent nitralloy quenching tempering nitriding double shot peening special emphasis placed combination nitriding shot peening technologies nitriding shot peening significantly modified differ classical processes nitriding carried way preventing formation compound surface layer formed nitrides epsilon gamma shot peening carried double stage operation help change parameters result combining modernized processes new technology developed guaranteeing possibility attainment contact fatigue limit comparable limit obtained carburizing induction hardening paper describes methodology experimental work well obtained values contact fatigue strength surface parameters also given roughness hardness state distribution residual stresses
based single phase converter controllable phase amplitude accpa three phase accpa without third harmonic trap proposed power transmission control grid adopting symmetrical relationship three phase three phase accpa comprised two parts used adjust phase amplitude three phase output voltage respectively continuously front part made three buck type converters back part three phase boost type converter operation principle three phase accpa adjustable ranges phase amplitude front part calculation formulas control parameters ideal conditions studied deduced detail furthermore control accuracy phase angle discussed three phase accpa digital control method select close loop control parameters obtained control strategy three phase accpa presented prototype fabricated experimental waveforms testing results verified correctness theoretical analysis feasibility control strategy
future home networks expected become extremely sophisticated yet technically adept persons equipped skills secure paper provide novel solution detect prevent attacks home routers based anomalous power consumption developed means measuring power consumption could used wide variety home networks although primary focus profiling homenet based residential routers specifically detect attacks homenet routing infrastructure several experimental results presented infrastructure exposed various types attacks show strong evidence feasibility approach
despite renewed efforts better understand glacier change recognize glacier change trends andes relatively large areas andes argentina chile still investigated study report glacier elevation mass changes outer region northern southern patagonian icefields southern patagonian andes newly compiled landsat etm derived glacier inventory consisting glaciers similar ice area differencing srtm spot dems used derive glacier specific elevation changes period investigated glaciers showed volume change yielding surface lowering average overall mass loss highly variable individual glacier responses observed interestingly less negative previously reported neighboring patagonian icefields
background aggression comprises heterogeneous set behavioral patterns aim harm hurt others empathy represents potential mechanism inhibits aggressive conduct enhances prosocial behavior nevertheless research results relationship empathy aggression mixed subtypes aggressive behavior reactive proactive aggression might differently related empathy aim present study investigate interrelations cognitive affective empathy reactive proactive aggression methods recruited sample female age adolescents socio educational juvenile justice institutions community sample female age adolescents secondary schools using bivariate correlation analysis hierarchical multiple regression analysis firstly investigated associations cognitive affective empathy reactive proactive aggression subsequently performed cluster analysis identify clusters adolescents meaningful profiles aggressive behavior compared derived clusters measures empathy applied basic empathy scale reactive proactive aggression questionnaire results bivariate analysis hierarchical regression analysis showed cognitive affective empathy negatively associated proactive aggression reactive aggression cluster analysis revealed three clusters adolescents distinct aggression profiles cluster elevated scores reactive proactive aggression clusters high scores reactive aggression low aggression cluster cluster comparisons revealed reactive proactive aggression cluster showed significantly lower scores cognitive affective empathy clusters results indicated within reactive proactive aggression cluster girls differ significantly boys empathy conclusions present study extends previously published findings possibly explains conflicting results prior research results indicated cognitive affective empathy reduced adolescents high levels reactive proactive aggression study may contribute development tailored clinical interventions different aggression clusters
human infants involved communicative interactions others well start speak understand language generally thought communication useful establishing interpersonal relations supporting joint activities absence symbolic functions language provides early communicative contexts allow infants learn world however recent studies suggest someone demonstrates something using object medium instruction infants conceive object exemplar whole class objects kind thus object like word play role symbol stands something else infants learn general knowledge kind object nonverbal communication single item kind rudimentary symbolic capacity may one roots development symbolic understanding children
urban highway network system tokyo metropolitan expressway detect conditions road pavement expansion joints important issue although accurate surface condition captured using road profiler system operating cost expensive development simpler inexpensive system really needed reduce monitoring cost vehicle intelligent monitoring system vims developed purpose described paper accelerometer gps installed ordinary road patrol car gps together computer used measure road surface condition identify location vehicle respectively dynamic response vehicle used measure road pavements surface condition well expansion joints prototype vims installed motor car measurement made actual roads accuracy measuring result effectiveness system demonstrated outline system measurement results reported herein
aims investigate relationship volition physical activity weight loss maintenance methods recruited sedentary maximal oxygen uptake min overweight obese body mass index bmi fat women men interdisciplinary prospective study follow change lifestyle weight loss promoted via month intensive lifestyle intervention private health school intervention consists supervised training hours day healthy hypo caloric diet kcal day education healthy lifestyle classes groups participants body weight composition dual energy ray absorptiometry volitional skills questionnaire physical activity level heart rate accelerometer questionnaire maximal oxygen uptake indirect calorimetry monitored months intervention results month follow three different groups established clinical weight loss maintenance weight loss baseline moderate weight loss maintenance weight loss weight loss weight regain linear mixed model analysis used compare levels volitional skills physical activity maximal oxygen uptake time three groups correlational analyses used investigate possible associations volition maximal oxygen uptake physical activity level weight loss maintenance conclusions specific volitional skills identified predictors adherence physical activity success clinical weight loss maintenance trained future intensive lifestyle interventions order optimize success rate
introduction cariprazine rgh novel antipsychotic drug exerts partial agonism dopamine receptors preferential binding receptor antagonism htb receptors partial agonism hta interesting pharmacodynamic profile suggests potential treatment plethora psychiatric disorders present comprehensive review aims summarizing current evidence safety tolerability efficacy cariprazine treatment schizophrenia manic mixed depressive episode mdd evidence acquisition literature search carried pubmed medline scopus database clinical trials inception december typing set specified keywords evidence synthesis cariprazine appears efficacy treatment cognitive negative symptoms schizophrenia preliminary findings suggest antimanic activity whilst still investigation efficacy treatment bipolar depression mdd conclusions studies needed order better identify clinical efficacy profile
previous communication studies focused media content influences human aggression studies however conducted regarding influence situational variables human aggression regarding online gaming present study examines game users aggression influenced two idiosyncratic situational variables degree control playing watching degree interaction alone together feeling presence also examined mediator explicate mechanism situational variables influence game users levels aggression results demonstrate degree control significantly affects users aggression aggression increased players actively participate game versus simply watching situational factors associated way people engage interactive media cause short term shifts players aggression implications future research directions discussed
novel zero attraction affine projection sign algorithm apsa strong impulsive sparse environment proposed paper norm penalty introduced original cost function apsa provides zero attraction filter weights apsa provides lower computational complexity robust impulsive noise whereas apa works well sparse environment improved convergence lower steady state error proposed apsa combines feature apsa apa hence provides faster convergence lesser steady state error high robustness impulsive interference low computational complexity conventional ones stability condition convergence mean mean square error sense derived theoretical analysis made prove proposed algorithm achieve lesser steady state mean square error apsa simulations performed validate analysis made prove suitability proposed algorithm sparse impulsive system identification
osteoarthritis degenerative joint disease caused excessive death chondrocytes loss extracellular matrix ecm articular cartilage previously reported reactive oxygen species ros generated nadph oxidase nox isoform nox involved chondrocyte death induced interleukin beta beta study investigate role nox production degradation ecm chondrocytes although beta lowered mrna expression type collagen cola aggrecan acan mouse chondrocyte like atdc cells rna silencing nox change mrna expression major components ecm cartilage hence nox involved beta induced suppression ecm production hand nox inhibitor aminoethyl benzenesulfonyl fluoride aebsf ros scavenger acetylcysteine antisense oligodeoxynucleotide nox prevented loss proteoglycan induced beta highly differentiated atdc cells furthermore aebsf affect expression hyaluronidase whereas suppressed hyaluronidase activity culture medium beta induced intra extracellular acidification also suppressed aebsf antisense oligodeoxynucleotide nox since hyaluronidase activity known higher acidic conditions nox probably contributes ecm loss activation hyaluronidase acidification
volatile organic compounds vocs detection high demand clinic treatment environment monitoring food quality control especially vocs human exhaled breath serve significant biomarkers diseases lung cancer diabetes study smartphone based sensing system developed real time vocs monitoring using alternative current impedance measurement interdigital electrodes modified zinc oxide zno graphene nitrocellulose used sensors produce impedance responses vocs responses could detected hand held device sent smartphone bluetooth reported concentration android program smartphone smartphone based system demonstrated detect acetone concentrations low ppm impedance spectroscopy used distinguish acetone vocs finally measurements exhalations human carried obtain concentration acetone exhaled breath exercise results proved smartphone based system could applied detection vocs real settings healthcare diagnosis thus smartphone based system vocs detection provided convenient portable efficient approach monitor vocs exhaled breath possibly allowed early diagnosis diseases
ability solve mathematical problems related purchasing personal finance important promoting skill generalization increasing independence individuals moderate intellectual disabilities ids using multiple probe across participant design study investigated effects modified schema based instruction msbi personal finance problem solving skills purchasing item sale leaving tip using calculator idevice iphone ipad three middle school students diagnosed moderate results showed functional relation msbi using calculator participant ability solve addition subtraction personal finance word problems generalize idevices findings study provide several implications practice offer suggestions future research
distributed computing guarantees basic level change way utilize pcs get store specific business data new registering correspondences models develop new data security challenges existing information security structures instance encryption fizzled imagining information theft strikes particularly executed insider cloud supplier propose substitute methodology securing information cloud utilizing adversarial mimic improvement screen data access cloud perceive unpredictable data access outlines right unapproved access suspected confirmed using test questions dispatch disinformation strike giving back considerable measure fake information attacker secures misuse customer real data trials coordinated neighbor hood archive setting give confirmation technique may give unprecedented levels customer data security cloud space
test association arcuate foramen first cervical vertebra acute headache attributed whiplash retrospective study patients suffered whiplash presence absence recorded radiographic study well presence absence acute headache whiplash frequency patients bilateral presented significant fisher test increase frequency acute headache comparison non group ratio presence absence acute headache times higher subjects bilateral comparison non subjects presence bilateral associated increased frequency acute headache suffering whiplash information interest attention patients
internet things natural continuity ambient intelligence smart ambient environments built integrating large number interconnected smart objects heterogeneous capabilities abstracted software services aim design cross domain applications compose select relevant services best match user requirements closely meet specified quality service level however semantic description representation smart devices including hosted services provided real world data still challenging issue semantic web technologies seen promising tool purpose indeed applying technologies internet things enables smart objects efficiently share data exchange services cooperate better satisfy functional non functional user requirements paper propose new semantic model smart objects description users request resolution using ontological techniques combined description logics model facilitates intelligent functions including reasoning service data semantic interoperability enabling among devices case study smart environment monitoring proposed illustrate effectiveness usability approach authors published elsevier
background aimsalcohol marijuana widely used among college students emotion regulation strategies linked alcohol marijuana use little attention devoted modeling directionality associations aims current study test whether daytime use emotion regulation strategies influences likelihood evening substance use evening substance use influences likelihood next day use emotion regulation strategies designlongitudinal daily diary data collected days via line surveys settingnortheastern united states participantsa total college students mean age years female european american recruited semester spring spring measurementsdaily diaries assessed emotion regulation strategies distraction reappraisal problem solving avoidance substance use drinking heavy drinking marijuana use use drinking heavy drinking marijuana covariates included gender age race ethnicity fraternity sorority involvement baseline depression findingsdaytime distraction odds ratio reappraisal problem solving predicted lower odds evening marijuana use values evening heavy drinking marijuana use predicted lower odds next day problem solving heavy drinking also predicting higher odds next day avoidance marijuana use also predicting higher odds next day reappraisal values conclusionsthere appear reciprocal relations among emotion regulation strategies substance use greater daytime use distraction reappraisal problem solving predicts lower evening substance use higher evening substance use predicts higher next day avoidance reappraisal lower next day problem solving
study investigated implication preceding high trauma fracture subsequent high low trauma fractures different skeletal sites postmenopausal women similarly aged men age range years preceding high trauma fracture increases risk future low trauma non vertebral fractures including hip little known impact skeletal fracture site conjunction severity past fracture high low trauma preceding fracture effect future fracture risk patients novo high low trauma fractures admitted seven large trauma centers across austria stratified sex different age groups kaplan meier estimates cox proportional hazards regression models likelihood calculations estimated effects age sex anatomic region probability subsequent fracture patient included study female male patients age range years novo high low trauma fractures age range years subsequent fractures observed females males preceding high trauma fracture associated subsequent fractures thereof high low trauma origin usually hip humerus pelvis highest effect sizes observed femur humerus thorax fractures hazard ratios splitting high trauma preceding subsequent low trauma fractures femoral neck female sex age discriminators increased future fracture risk preceding high trauma fractures increase risk future low trauma non vertebral fractures including hip patient fracture regardless severity trauma osteoporosis taken clinical consideration
background childhood brain tumours longest time diagnosis timely diagnosis may role reducing anxiety waiting diagnosis subsequent morbidity mortality investigated opportunities earlier diagnosis anatomical locations strategy likely effective methods record linkage cohort study patients diagnosed aged years primary intracranial tumour england using records national cancer registry linked hospital admission records hospital episode statistics hes primary care consultation records clinical practice research datalink cprd relevant neurological presentations extracted hes cprd temporal changes presentation rates estimated general ised additive models results frequency presentation began increase six months diagnosis primary care three months diagnosis hospital supratentorial midline tumours longest presentation history diagnosis peri ventricular tumours presented frequently hospital rate ratio supratentorial tumours emergency primary care conclusions opportunities earlier diagnosis greater supratentorial midline cranial nerve tumours longer presentation history peri ventricular cerebellar brainstem tumours common features diagnosis include headache convulsions growth endocrine disorders focal neurological deficits uncommon emerge late pre diagnosis period european paediatric neurology society published elsevier ltd rights reserved
people schizophrenia increased risk compared general population acquire convictions violent crimes homicide also show elevated levels aggressive behaviour psychotic symptoms explain aggressive behaviour common acute episodes explain behaviour stages illness prior illness onset three distinct types offenders identified individuals childhood onset conduct disorder display antisocial aggressive behaviour schizophrenia onset individuals history conduct problems begin engaging aggressive behaviour illness onsets individuals many years illness engage severe physical assault little known aetiology three types offenders neural mechanisms initiate maintain behaviours hypothesize schizophrenia preceded conduct disorder associated combination genes conferring vulnerability disorders altering effects environmental factors brain thereby distinct pattern abnormal neural development contrast offending among adults schizophrenia history behaviour prior illness may result changes brain occur illness onsets altered substance misuse progressive changes brain adulthood result illness use antipsychotic medications
cobicistat pharmacokinetic booster several fixed dose combination products treatment human immunodeficiency virus hiv infection potent inhibitor cytochrome cyp enzymes significant drug drug interactions expected cobicistat medications metabolized primarily cypa pathway including calcineurin inhibitors tacrolimus cyclosporine describe case tacrolimus toxicity due supratherapeutic tacrolimus concentrations stribild elvitegravir cobicistat emtricitabine tenofovir disoproxil fumarate initiated newly diagnosed hiv infection year old renal transplant recipient previously receiving stable tacrolimus regimen drug drug interaction via cypa inhibition acknowledged weekly labs ordered allow close monitoring renal function tacrolimus serum concentrations recommended stribild prescribing information patient reported headache insomnia stomachache decreased urine output within week starting stribild found acute kidney injury serum creatinine concentration increasing serum tacrolimus concentration week follow goal trough level tacrolimus stribild withheld days patient tacrolimus serum concentration returned goal interim required twice week clinic visits laboratory assessments emergency department visit management hyperkalemia potassium meq triumeq abacavir dolutegravir lamivudine started weeks later returned baseline tacrolimus serum trough concentrations subsequently remained stable knowledge first case report describing extent significance onset cobicistat tacrolimus drug drug interaction clinical practice fixed dose combination products including cobicistat pharmacokinetic booster come market clinicians reminded multitude clinically significant drug drug interactions
integrating multi source geoscience information geology geophysics geochemistry remote sensing using gis mapping one key topics frontiers quantitative geosciences mineral exploration gis prospective mapping three dimensional modeling used extract exploration criteria delineate metallogenetic targets also provide important information quantitative assessment mineral resources paper uses shangnan district shaanxi province china case study area gis mapping potential granite hydrothermal uranium targeting conducted study area combining weights evidence wofe concentration area fractal methods multi source geoscience information deposit scale modeling using gocad software performed validate shapes features potential targets subsurface research results show known deposits potential zones depth geological models delineate surface subsurface ore forming features used analyze uncertainty shape feature prospectivity mapping subsurface single geochemistry anomalies remote sensing anomalies surface require combining depth exploration criteria geophysics identify potential targets single sparse exploration criteria zone mineralization spots surface high uncertainty terms exploration target elsevier ltd rights reserved
ionic polymer metal composite ipmc fast growing type smart material wide range applications ipmc used extensively actuator effective usage one must add self sensing ability two common self sensing techniques mechanical electrical transducer surface resistance first one used actuator running second one needs sample modification work present new self sensing method measure external disturbance presence actuator voltage without sample modification resistance across ipmc sample follows ohm law sufficiently high frequency exploit frequency dependency resistance across sample design self sensing method technique function generator lock amplifier isolation circuit employed measure external impulse steady disturbance implementing technique require change ipmc specimen electrical connection hanger added existing electroactive device
cognitive motor performance measures commonly employed multiple sclerosis research particularly purpose determine efficacy treatment increasing focus new therapies slowing progression reversing neurological disability makes utilization sensitive reproducible valid measures essential processing speed basic elemental cognitive function likely influences downstream processes memory multiple sclerosis outcome assessments consortium msoac includes representatives advocacy organizations food drug administration fda european medicines agency ema national institute neurological disorders stroke ninds academic institutions industry partners along persons living among msoac goals acceptance qualification regulators performance outcomes highly reliable valid practical cost effective meaningful persons critical step neuroperformance metrics elucidation clinically relevant benchmarks well defined degrees disability gradients change deemed clinically meaningful topical review provides overview research one particular cognitive measure symbol digit modalities test sdmt recognized particularly sensitive slowed processing information commonly seen research clearly supports reliability validity test recently supported responder definition sdmt change approximating points magnitude
years various path planning problems brought addressed example shortest path first algorithm usually adopted search best route source destination packet transmission network case add distance every segment along available routes choose one least value path planning problems sort often use evaluation functions commutative nature however case objective plan biking driving route safe fun ordinary evaluation functions especially commutative ones usually fail resolve issue properly accordingly paper propose conventional non commutative path planning strategy well algorithm address problem efficient manner
background interleukin pleiotropic cytokine critical development survival multiple haematopoietic lineages mice lacking selective defects populations several pro allergic immune cells including natural killer cells nkt cells memory cells therefore hypothesized mice reduced inflammatory responses development allergic airway disease aad objective determine whether mice attenuated allergic responses mouse model aad methods cbl wild type mice sensitized challenged ovalbumin ova development aad ascertained examining changes airway inflammatory responses responses lung histopathology results report mice developed enhanced allergic responses ova induced model aad absence ova challenged mice exhibited enhanced bronchial eosinophilic inflammation elevated production severe lung histopathology comparison mice addition increased numbers cells spleens bronchoalveolar lavage bal also observed examination ova challenged animals revealed similar phenotype resulting enhanced airway eosinophilia compared mice adoptive transfer splenic cells ova sensitized mice suppressed enhancement eosinophilia animals levels observed mice effects conclusion clinical relevance data demonstrate mice endogenous deficiency susceptible development severe enhanced mediated aad regulated cells furthermore development disease well allergen specific responses occurs despite deficiencies several dependent cell types including nkt cells suggesting cells subsets dispensable induction aad deficient mice
various mutations park gene encodes protein parkin significantly associated onset autosomal recessive juvenile parkinson arjp neuronal cells parkin multi domain protein terminal part contains uhl terminal part consists four zinc coordinating domains viz ring ring ring ibr ring disease mutations spread domains parkin although mutations regions may affect functionality parkin adversely mutations ring domain seen abolish neuroprotective ligase activity parkin current work carried detailed silico analysis study extent pathogenicity mutations spanning parkin ring domain adjoining rep region sift mutation accessor polyphen snps mutant study structural functional implications mutations ring rep domain parkin studied solvent accessibility sasa rsa hydrophobicity intra molecular hydrogen bonding profile domain analysis various computational tools finally analysed interaction energy profiles mutants compared wild type protein using discovery studio comparing various analyses could safely concluded except mutations mutations potentially deleterious affecting various structural aspects ring domain architecture study based purely computational approach potential identify disease mutations information could used treatment diseases prognosis elsevier rights reserved
simultaneous relief pain body brain remains ongoing challenge aim present study clarify whether plant derived isoflavone puerarin could ameliorate comorbid depression pain investigated effects puerarin depressive like behaviors neuropathic pain cbl mice spared nerve injury sni sni surgery mice allowed recover spontaneously days subsequently treated puerarin anti depressant citalopram analgesic ibuprofen alone combination days forced swim test tail suspension test used assess depressive like behaviors whereas von frey filament test used estimate sensitivity mechanical stimulation results suggested puerarin effectively ameliorated depression pain sni mice although citalopram exhibited anti depressant activity contrast ibuprofen showed lesser activities sni induced depression pain mechanistic studies revealed uniqueness puerarin follows puerarin recover sni induced depletion reduced glutathione loss superoxide dismutase sod whereas citalopram ibuprofen showed somewhat antioxidant activities puerarin markedly promoted activation creb pathway although puerarin citalopram activated erk pathway extent puerarin rapidly persistently induced brain derived neurotrophic factor bdnf expression whereas citalopram induced bdnf expression prolonged stimulation collectively results suggest puerarin may ameliorate sni induced depression pain via activating erk creb bdnf pathways puerarin may serve new lead compound development novel therapeutics depression pain comorbidity
distributed computing environments frequent pattern mining multi computing node greatly improve mining efficiency however drawback memory limitations may cause interruption kernel computing nodes recursively building frequent pattern tree growth algorithm paper propose disk based tree generation node based clustering mechanisms solve insufficient memory problem results empirical evaluations show proposed method delivers excellent scalability
background identification biomarkers cigarette smoke induced lung damage early copd area intense interest glucose regulated protein grp multi functional protein mediates cell responses oxidant stress increased lungs cigarette smokers serum subjects copd suggested secretion grp lung cells may explain increase serum grp copd assess grp secretion lung assayed grp bronchoalveolar lavage fluid balf chronic smokers non smokers also directly assessed acute effect cigarette smoke material grp secretion isolated human airway epithelial cells haec methods grp measured balf smokers non smokers western blotting grp secretion haec assessed comparing concentration cell culture medium cell lysates cells treated either volatile phase cigarette smoke cigarette smoke extract cse particulate phase cigarette smoke condensate csc results grp present balf levels significantly greater grp secreted constitutively haec cse increased grp cell conditioned medium without affecting intracellular concentration contrast csc increased intracellular grp expression affect grp secretion brefeldin inhibitor classical golgi secretion pathways inhibit grp secretion indicating non classical pathways involved conclusion present study indicates grp increased balf cigarette smokers haec secrete grp grp secretion haec augmented cigarette smoke particulates enhanced secretion grp lung cells makes potential biomarker cigarette smoke induced lung injury
increasing pressures faced manufacturers shortening innovation cycles growing importance high efficiency manufacturing demand higher versatility factory automation order achieve target engineering tasks currently performed manually need automated case ontologies emerge significant method representing manufacturing knowledge machine interpretable way knowledge used automated problem solving methods reconfigure control software coordinates supervises manufacturing systems besides ontology play important role process creating well managing knowledge paper addresses important issues developing domain specific ontology manufacturing used industry demonstration production line generic ontology developed considering aspects product customized order resulting production
mindfulness construct defined paying attention purpose present moment nonjudgementally present experience kabat zinn considered part third generation techniques cognitive behavioural therapies applied several fields benefits important variables stress anxiety levels pain life quality recently used first time sports psychology increase performance levels athletes well defined programs birrer aim article analyze mindfulness based interventions see potential benefits advantages mindfulness could bring prevention rehabilitation sports injuries
immune function amigo currently unknown revealed novel roles amigo modulating cell functions eae using amigo knockout amgk mice amigo abundantly expressed murine helper cells deficiency impaired transplanted cell infiltration secondary lymphoid organs dampened cell activation promoted splenic cell proliferation abundancy therein amgk cells respectively elevated bet gata lineage early cell differentiation accompanied increased ifn gamma decreased production amgk mice exhibited ameliorated eae dampened spinal cell accumulation decreased serum levels enhanced splenic production adoptive transfer encephalitogenic amgk cells induced milder eae dampened spinal cell accumulation tnf expression mechanistically amigo overexpression cells dampened transcriptional activity amigo deficiency enhanced akt suppressed gsk beta phosphorylation promoted nuclear translocations nfat cells collectively data demonstrate amigo important regulating cell functions eae may harnessed potential therapeutic target multiple sclerosis elsevier inc rights reserved
sustainable living living within bounds available environmental social economic resources focus many present day social scientific discussions sustainability mean within context software engineering paper undertake comprehensive analysis case studies address question within context specific software engineering approach software product line engineering sple identify sustainability related characteristics arise present day studies apply sple conclude technical economic sustainability prime focus present sple practice social sustainability issues relate organisations also addressed good degree hand issues related personal sustainability less prominent environmental considerations nearly completely amiss present feature models cross relations result analysis starting point sustainability engineering sple suggesting new development consider models would instantiated expanded intended sociotechnical system good representation sustainability features models also validated additional case studies
ability blood vessel change diameter response change carbon dioxide concentration often referred vasomotor reactivity study aimed determine whether vasomotor reactivity impaired patients idiopathic parkinson disease comparison healthy controls transcranial doppler used measure cerebral blood flow velocity middle cerebral arteries baseline hypocapnic conditions patients idiopathic parkinson disease healthy controls vasomotor reactivity assessed hypocapnic conditions impaired patients idiopathic parkinson disease comparison healthy controls
background latinos largest minority group united states california outnumber non hispanic whites smoking cessation programs tailored latino culture population specific smoking patterns needed online social networks smoking cessation high potential latinos tested date objective building research program social media apps cancer prevention diverse populations qualitative study assessed acceptability tobacco treatment distributed via social media latino smokers methods conducted three focus groups latino adults former current smokers recruited santa clara county california assessed participants smoking histories attempts quit social media exposure receptivity social media based smoking cessation intervention audio transcripts translated coded themes results participants reported factors driving tobacco use motivations quit emphasized importance community family influencing smoking initiation cravings triggers attempts quit abstinence participants valued communal aspect social media suggested strategically tailoring groups based key features age gender language preference participants reported preferring visual educational motivational messages connected existing services conclusions participants generally voiced acceptability social media delivered intervention help quit smoking viewed intervention well equipped catering strong community orientation latinos suggested platform able address variation within population strategic group creation group member reflected podemos hacerlo juntos together
unique light absorption property semiconductors exploited build photovoltaic photo electrochemical solar cells pesc photocatalytic reactors convert sunlight electrical energy also drive useful chemical reactions hydrogen clean fuel century targeted several decades however systems possess complex architecture two semiconductor solution interfaces often plagued material instability show poor photon conversion efficiency demonstrate simple pristine polyaniline pani film based photo generating system wireless system one pani solution interface utilizes internal redox chemistry conjugated polymer photo exciton formation charge separation electrons migrate pani hso interface reduce produce polymer film light weight flexible solution processable reported system simple scalable high volume production hydrogen elsevier ltd rights reserved
type ill interferon ifn lambda recently discovered family ifns shares common features type ifns also many distinctive activities clear whether ifn lambda additional antiviral mechanisms study investigated effects ifn lambda autophagy cellular process closely related hepatitis virus hcv infection human hepatoma huh cells results showed ifn lambda treatment inhibit autophagic activity huh cells evidenced decreased expression microtubule associated protein light chain lcb conversion lob lob decreased formation gfp puncta accumulation autophagosomes ifn lambda could also inhibit hcv induced tunicamycin known inducer autophagy similar mechanism hcv infection induced lob expression autophagosome formation pcr array real time pcr western blot two autophagy related genes atg gabarap identified verified regulated ifn lambda treatment either hcv uninfected huh cells hcv jfh infected cells overexpression atg gabarap could partly recover ifn lambda inhibited hcv replication mechanism research demonstrated ifn could induce expression mir mir targeting atg gabarap respectively regulates atg gabarap expression taken together results indicate suppression autophagy response ifn lambda contributes ifn lambda anti hcv activity results also provide theoretical basis improving effectiveness ifn treatment hcv infection inhibition hcv induced autophagy response
article explores qualitative shadowing interpretivist methodology explains two researchers participating simultaneously data collection using video recorder contextual interviews video stimulated recall interviews conducted qualitative shadowing study six early childhood centres norway paper emerged discussion experience another researcher shared interests early childhood leadership benefits research methodology studying leadership practices early childhood centres argue qualitative shadowing methodology powerful resource enrich leadership learning development within early childhood sector facilitating reflective engagement practitioners researchers qualitative shadowing possible enhance exploration complex phenomenon early childhood leadership practice
increase massive data large number business applications began seek effective scalable frameworks data storages processing background emerging technologies big data hadoop based systems use scalable distributed storage system hbase become available since business data nowadays stored relational databases information imprecision uncertainty widely exist real world applications increasing willingness manage large scale fuzzy relational data hadoop based platform paper concentrates fuzzy information modeling hbase particular investigate formal transformation fuzzy relational data model hbase model develop set mapping rules assist transformation process addition present generic approach transform fuzzy relational algebra fuzzy hbase manipulation language
similarity join xml documents usually modeled rooted ordered labeled trees widely applied due ambiguity references real world objects conventional method dealing issue based tree edit distance shortage flexibility efficiency paper propose two novel edit operations together extended tree edit distance achieve good performance similarity matching hierarchical data structures run time worst case propose generation set distance good approximation tree edit distance improve join efficiency quadric time complexity experiments real synthetic databases demonstrate benefit method efficiency scalability
information retrieval web search present challenging question researches today users urge accurate precise hands information search machine interpreting user query goal major challenge past present numerous algorithms frameworks proposed fail incorporate user aims query without proper intent processing retrieves irrelevant information pattern discovery ability solve limitations keyword image disambiguates phrase learning pattern discovery today search machines based ranking model eliminating boolean retrieval constraint boosting natural language use even though word sense concept extraction major challenge comes keywords information presented better way image presentation used news portals communicate fastly happing news social websites instagram facebook flicker user purchase goods sighting product images flipkart today uses sifted approach text based information image based given rise research domain image information retrieval iir large number image attributes also give rise image classification ambiguity relevance major factor influence information retrieval system performance impact precision recall relevance ranking methodology opted retrieve optimized relevant results eliminating non relevant large amount image associated word annotations present different web portals research build semantic search engine selects network design pattern integrate reinformant learning approach agent based learning help selecting information various networks help network structuring wair web agents information retrieval architecture core agent helping retrieving precise objects different portals linking optimized procedure simrank implemented count link semantic network content based knowledge learning reinforcing better results performance evaluation show proposed architecture algorithm design present faster relevance result image based recommendation system research outcome contributes image retrieval domain research work developed studying core vital articles image retrieval find research scope major challenges common ground need addressed found research analysis query raq help directing study better techniques overcome problem research innovation reinforment learning algorithm agent based system development existing state art present algorithms optimized innovation integration future scope research lies image image base retrieval video recommendation system
etiological mechanism underpinning sports related injury complex multifactorial frequently athletes perceive excessive training principal factor injury observation biologically plausible yet somewhat ambiguous applied training load suddenly increased may increase risk sports injury development irrespective absolute amount training indeed little rigorous scientific evidence exists support hypothesis fluctuations training load compared absolute training load important explaining sports injury development one reason could prospective data scientific studies analyzed different manner time event analysis useful statistical tool analyze influence changing exposures injury risk however potential time event analysis remains insufficiently exploited sports injury research therefore purpose present article present discuss measures association used time event analyses present advanced concept time varying exposures outcomes paper different measures association cumulative relative risk cumulative risk difference classical hazard rate ratio presented nontechnical manner suggestions interpretation study results provided summarize time event analysis complements statistical arsenal sports injury prevention researchers enables analyze complex highly dynamic reality injury etiology injury recurrence time recovery across range sporting contexts
paper proposes general architecture testing validating verifying ambient intelligence ami environments amisim development ami complex task technology must often adapt contextual information well unpredictable behaviours environmental features architecture presented deals ami applications order cover different components kinds systems environment users context adaptation architecture first one able cover features needed full ami system paper shows amisim able cover complete ami system provide framework test scenarios would impossible test real environments even previous simulation approaches simulated real elements coexist amisim robust testing validation verification ami systems provide easier less costly deployment
protein phosphorylation important regulatory functions cell homeostasis tightly regulated kinases phosphatases tegument human cytomegalovirus cmv contains several proteins reported extensively phosphorylated also cellular protein phosphatases ppa investigate apparent inconsistency evaluated phosphorylation status tegument proteins pul enzymatic dephosphorylation enzymatic dephosphorylation bacterial lambda phosphatase shifted pul specific signal reducing sds page similar similar kda mass still much larger similar kda obtained diffusion studies calculated protein mass similar kda remarkably inhibition phosphatases treatment phosphatase inhibitors calyculin okadaic acid resulted shift similar similar kda respectively indicating considerable number potential phosphorylated residues pul phosphorylated normal conditions revealed general state hypophosphorylation cmv phosphoproteins phosphorylated residues detected pul respectively moreover bioinformatics analysis shows terminal two thirds pul intrinsically disordered phosphorylations map region conclusion show important cmv tegument proteins indeed phosphorylated though lesser extent previously reported difference mobility sds page calculated mass pul may attributed phosphorylation likely due partially intrinsically disordered nature pul
objective thyroid disorders especially hashimoto thyroiditis observed significantly often patients polycystic ovary syndrome pcos general population approximately respectively extremely important young women disorders connected fertility problems pcos occur together fertility problems may become serious clinical issue patients materials methods systematic literature review pubmed pcos related articles english published december conducted results reasons joint prevalence still remain unclear genetic autoimmune backgrounds recognized possible common etiological factors three genetic poly morphisms described play role pcos well polymorphism gene fibrillin fbn regulating activity transforming growth factor tgf beta regulatory cell levels gonadotropin releasing hormone receptor gnrhr polymorphism cypb polymorphism standing estradiol hydroxylation high estrogen progesterone ratios owing anovulatory cycles well high estrogen levels prenatal life disrupt development thymus function maintaining immune tolerance suspected enhance autoimmune response pcos vitamin deficiency could also involved pathogenesis pcos conclusions mentioned common etiological factors associated fertility problems pcos require research
aging causes micro macrovascular endothelial dysfunction assessed endothelium dependent dilation edd prevented reversed habitual aerobic exercise men however estrogen deficient postmenopausal women whole forearm microvascular edd studied beneficial effect macrovascular edd consistently shown assessed forearm blood flow response brachial artery infusions acetylcholine fbfach measure whole forearm microvascular edd brachial artery flow mediated dilation fmd measure macrovascular edd premenopausal sedentary women pre dot omax min estrogen deficient postmenopausal sedentary women post dot omax min estrogen deficient postmenopausal trained women post dot omax min fbfach lower post post compared pre women auc respectively whereas post post women different brachial artery fmd lower post post respectively pre women different post post women post women lower circulating reactive protein oxidized low density lipoprotein compared post women respectively markers correlated fbfach brachial artery fmd findings consistent idea habitual protect age menopause related whole forearm micro macrovascular endothelial dysfunction healthy nonobese estrogen deficient postmenopausal women despite associated lower systemic markers inflammation oxidative stress new noteworthy first study demonstrate habitual aerobic exercise may protect age menopauserelated whole forearm microvascular endothelial dysfunction healthy nonobese estrogen deficient postmenopausal women consistent recent findings regarding macrovascular endothelial function contrast observed healthy middle aged older aerobic exercise trained men
array pharmacological environmental factors influence development maintenance tobacco addiction nature influences likely changes across course extended smoking history time drug seeking become involuntary uncontrolled present study used animal model examine factors drive nicotine seeking behavior either brief days extended days self administration training experiment extended training increased rats sensitivity nicotine indicated leftward shift dose response curve motivation work nicotine indicated increase break point achieved progressive ratio schedule experiment extended training imbued nicotine paired cue capacity maintain responding high level nicotine however experiment showed mechanisms involved responding nicotine nicotine paired cue dissociable treatment partial nicotine receptor agonist varenicline suppressed responding nicotine potentiated responding nicotine paired cue hence across extended nicotine self administration pharmacological environmental influences nicotine seeking increase nicotine seeking controlled multiple sources therefore highly resistant change
meshless methods convection dominated flow problems potential reduce computational effort required given order solution accuracy compared mesh based methods state art field advanced elliptic partial differential equations time dependent convection diffusion problems paper introduce new meshless method based combining modified method characteristics radial basis functions solution reconstruction method belongs class fractional time stepping schemes predictor stage used discretization convection terms corrector stage used treatment diffusion terms special attention given application method solve convection dominated flow problems two dimensional domains numerical results shown several test examples including incompressible navier stokes equations computed results support expectations stable highly accurate meshless method international association mathematics computers simulation imacs published elsevier rights reserved
violent video games source controversy united states elsewhere several decades considerable concern raised public scientific communities alleged deleterious effects violent games concerns may coincide periodic moral panics media influence particularly youth paper argues negative effects violent games exaggerated elements scientific community fitting past cycles media focused moral panics contrast potential positive effects violent video game play ignored debate violent games current paper considers research several areas including aggression also nascent research fields visuospatial cognition social networking use educational tools argued debate video game violence broadened include potential negative positive effects
microgrid described electrical network small modular distributed generation energy storage devices controllable loads order maximize output solar arrays maximum power point tracking mppt technique used artificial neural network ann also control turbine output power high wind speeds proposed using pitch angle control technic fuzzy logic track maximum power point mpp photovoltaic proposed ann trained genetic algorithm word data optimized optimum values used ann simulation results show ann comparison conventional algorithms high accuracy track peak power point different insolation conditions meet load demand less fluctuation around mpp also increase convergence speed achieve mpp moreover pitch angle controller based fuzzy logic wind speed active power inputs faster responses leads flatter power curves enhances dynamic responses wind turbine models developed applied matlab simulink copyright john wiley sons ltd
key component accelerator driven system ads spallation target exposed high irradiation intensity radiation larger amount heat deposited therefore cooling target challenging task target design integrated target module solid beam window cooled reactor primary coolant good contender ads system numerical analysis two target modules performed using finite element code assess target cooling capacity found uniform inlet velocity geometry modification inlet could improve heat transfer effectively non uniform inlet velocity geometry modification inlet little effect cooling capacity elsevier ltd rights reserved
rural communities face significant challenges regarding adequate availability diagnostic treatment support services individuals autism spectrum disorder asd specifically variety factors including geographic distance families service providers low reliance health care professionals cultural characteristics contribute diminished availability utilization services together factors lead risks delayed asd screening diagnosis yielding lower educational functional outcomes purpose review outline specific diagnosis treatment barriers affect individuals asd families rural settings telehealth feasibility efficacy research also reviewed suggesting telecommunication services may offer inroad addressing specific service barriers faced rural communities together current review identifies specific needs research support services address specific access barriers characteristic rural settings
objective purpose study present case report review relevant literature laxative induced dermatitis mistaken scald injury child abuse case month old girl presented partial thickness burn buttocks perineum suspected caused child abuse investigation parents administering large doses laxatives child chronic constipation discussion child abuse burning characteristic physical examination findings differ pattern laxative induced dermatitis reported literature diapers appear risk factor laxative induced dermatitis surprisingly dose laxative correlate severity burn injury physicians must aware possibility laxative induced dermatitis mimicking scald burn injury buttocks parents educated risk administering counter laxatives children
bloom filters bfs used many applications approximate check set membership counting bloom filters cbfs extension bfs enable deletion entries cost additional storage requirements several alternatives cbfs used reduce storage overhead example schemes based left hashing cuckoo hashing proposed recently also new type cbf variable increment counting bloom filter cbf introduced improve performance cbf uses different increments filter counters reduce false positive rate therefore storage requirements paper another mechanism improve cbf performance fingerprint counting bloom filter cbf presented proposed scheme based use fingerprints filter entries reduce false positive rate results simpler implementation cbfs terms number hash functions arithmetic operations false positive rate proposed scheme also analyzed theoretically simulation compared cbf results show proposed scheme achieve lower false positive rates simple cbf implementation compared better complex cbf implementation cbf outperforms number bits per element large cbf better low number bits per element elsevier rights reserved
purpose use social media particular community question answering websites learners increased significantly recent years vast amounts data posted sites provide opportunity investigate topics discussion receiving attention purpose paper automatically analyse content popular computer programming website stackoverflow determine exact topics posted narrow categories help determine subject difficulties learners authors able rank identified topics categories according frequencies therefore mark asked subjects hence identify difficult challenging topics commonly faced learners computer programming software development design methodology approach work authors adopted heuristic research approach combined text mining approach investigate topics categories posts website almost posts analysed categories refined using wikipedia crowd sourced classification system identifying counting occurrence frequency topics categories semantic relationships established data presented rich graph could visualized using graph visualization software gephi findings reported results corresponding discussion given indication insight gained process refined potentially used instructors teachers educators pay attention focus commonly occurring topics subjects designing course material delivery teaching methods research limitations implications proposed approach limits scope analysis subset contain one links wikipedia therefore developing sophisticated text mining methods capable analysing larger portion available data would improve accuracy generalizability results originality value application text mining data analytics technologies education created new interdisciplinary field research education information sciences called educational data mining edm work presented paper falls field research early attempt investigating practical applications text mining technologies area computer science education
background considering limited cross protection offered current hpv vaccines understanding hpv genotype distribution among different population essential predicting efficacy current vaccine devising new vaccine strategy present work aimed investigating hpv genotypes distribution among women without cervical carcinoma odisha eastern india methods total participants enrolled january june pcr sequencing nested multiplex type specific pcr performed hpv detection genotyping cytological distribution cases includes invasive cervical carcinoma icc inflammatory smear normal cytology statistical analyses performed using spss version software medical version value ofyears parity low socio economic condition rural residential area post menopause state significantly associated hpv infection multiple infections significant association clinicopathological variables stage metastasis cell type except tumor size icc cases impact vaccines preventing cervical cancer odisha respectively conclusion data would help planning appropriate strategy disease monitoring provides baseline data post vaccination surveillance region nonavalent vaccine would significant preventing cervical carcinoma odisha hence effective vaccination program based regional hpv epidemiological profile along cervical cancer screening necessary reduce cervical cancer burden india
successful decision making critically involves metacognitive processes monitoring control decision process metacognition enables agents modify ongoing behavior adaptively determine next situations external feedback immediately available despite importance metacognition many aspects life little known metacognitive system operates kind information used metacognitive second order judgments particular remains open question whether metacognitive judgments based information first order decisions investigated relationship metacognitive performance first order task performance recording eeg signals participants asked make diagnosis seeing sample fictitious patient data complex pattern colored moving dots different sizes assess metacognitive performance participants provided estimate quality diagnosis trial results demonstrate information contributes first order decisions differs information supports metacognitive judgments time frequency analyses eeg signals reveal metacognitive performance associated specifically prefrontal theta band activity together findings consistent hierarchical model metacognition suggest crucial role prefrontal oscillations metacognitive performance
advances brain computer interface bci technology facilitated detection motor imagery electroencephalography eeg first present three strategies using bci detect eeg operant conditioning employed fixed model machine learning employed subject specific model computed calibration adaptive strategy continuously compute subject specific model second review prevailing works employed operant conditioning machine learning strategies third present past work six stroke patients underwent bci rehabilitation clinical trial averaged accuracies calibration across online feedback sessions finally perform offline study paper work employing adaptive strategy results yielded significant improvements using data using limited preceding data respectively feedback accuracies results showed increase amount training data yielded improvements nevertheless results using limited preceding data showed larger part improvement due adaptive strategy changing subject specific models deteriorate accuracies hence adaptive strategy effective addressing non stationarity calibration feedback sessions
immune system plays crucial role progression alzheimer disease recently immune dependent cascade induced systemic immune activation verified play beneficial role mouse models tested whether bacillus calmette guerin bcg immunization alters pathology cognitive dysfunction app mouse model beta vaccination positive control found bcg treatment reversed cognitive decline extent observed beta group reduce pamyloid beta burden brain demonstrated enhanced recruitment inflammation resolving monocytes across choroid plexus perivascular spaces cerebral sites plaque pathology app mice immunized bcg furthermore elevated splenocyte foxp regulatory cell levels control app mice regulated back wild type levels bcg treatment beta vaccination addition bcg treatment induced production circulating interferon ifn gamma controls beta vaccination though similar reductions brain levels pro inflammatory cytokines observed bcg beta groups compared controls bcg great effect upregulating cerebral anti inflammatory cytokine levels well elevating expression neurotrophic factors brain app psi mice thus suggested bcg exerts beneficial immunomodulatory effect app mice mitigation systemic immune suppression induction ifn response alleviation neuroinflammatory response elsevier inc rights reserved
study aimed examine behavioural sleep wake rhythm adults autism spectrum disorder asd determine prevalence circadian sleep wake rhythm disorders compared age sex matched controls participants completed online questionnaire battery day sleep wake diary day actigraphy assessment results indicated higher proportion adults asd met criteria circadian rhythm sleep wake disorder compared control adults particular delayed sleep wake phase disorder particularly common adults asd overall findings suggest individuals asd sleep patterns may associated circadian rhythm disturbance however factors employment status morbid anxiety depression appear influence sleep patterns
objective physician follow first diagnosis psychotic disorder crucial improving treatment engagement examined factors associated physician follow within days first diagnosis schizophrenia method conducted retrospective cohort study using linked health administrative data identify incident cases schizophrenia among people aged years ontario estimated proportion patients physician follow within days index diagnosis used multilevel logistic regression models examine factors associated physician follow follow psychiatrist results identified people first diagnosis schizophrenia approximately people receive physician follow within days nearly receive follow psychiatrist males lower odds receiving physician follow odds psychiatrist follow decreased increasing age lower living rural areas prior contact general practitioner mental health reason prior contact psychiatrist strongly associated higher odds receiving types follow conclusions many people physician contact within days first diagnosis schizophrenia patients without prior engagement mental health services highest risk need information reasons behind lack physician follow inform strategies aimed improving engagement services early stages psychosis
background anaphylaxis life threatening condition limited therapeutic options although specific immunotherapy food allergies becoming effective still laborious carries substantial risk adverse events hand regulatory dendritic cell therapy effective mouse models allergic disease shown work cells atopic asthmatic patients objective assessed whether immunotherapy could reverse food allergen sensitivity mouse models provide proof concept relating use clinic methods generated characterized mature retinoic acid skewed dendritic cells ras assessed abilities reverse ovalbumin peanut allergies mouse models well operative mechanisms results ras displayed mature yet tolerogenic phenotype expressing tgf beta aldehyde dehydrogenase tgf beta together drove suppression cell proliferation delivery specific allergen presenting ras half maximally sensitized mice ovalbumin peanut allergy reduced anaphylactic responses oral allergen challenge well diarrhea mast cell activation cytokine responses serum allergen specific ige igg levels expression important induction lymphocyte activation gene lag cdb forkhead box foxp regulatory cells vitro subunit ebi incompetent ras ineffective inducing food allergen tolerance conclusion data indicate regulatory immunotherapy effective food allergies suggest induction foxp regulatory cells might useful strategy tolerance induction context
background aim analyzed whether insulin resistance assessed homeostasis model assessment homa index stratify hepatocellular carcinoma hcc risk patients chronic hepatitis virus hbv infection methods retrospective cohort chronic hbv infected patients age years men underwent detailed health checkup program including peptide fasting blood glucose measurement followed year analyzed results median follow years range years patients developed hcc hcc incidence rate higher patients higher homa value lower homa value homa homa significant factor associated hcc development multivariable adjusted model adjusted age sex cirrhosis hbv dna levels association homa hcc markedly attenuated became longer statistically significant adjusted obesity hypertension diabetes subgroup analysis homa value independent factor associated hcc patients without overt metabolic abnormalities hypertension diabetes metabolic syndrome overt metabolic abnormalities conclusion insulin resistance assessed homa associated risk hcc indicating homa useful tool stratifying risk hcc chronic hbv infected patients particularly patients without overt metabolic abnormalities
new findings central question study change plasma arginine vasopressin concentration avp response osmotic stimulation osm serve biomarker nmda receptor signalling schizophrenia depression thereby distinguish mental illnesses main finding importance response hyperosmotic challenge depressed subjects showed increased avp response compared healthy control schizophrenic subjects however schizophrenic subjects different healthy control subjects small sample avp response osm suitable biomarker distinguish depressed versus schizophrenic patients used psychiatric screening first objective physiological measure schizophrenia depression altered nmda receptor activity glutamate signalling might underlie pathogenesis schizophrenia depression subgroups patients schizophrenia pharmacological modelling post mortem imaging data suggest reduced nmda signalling contrast recent clinical trials demonstrating efficacy nmda antagonist ketamine severely depressed patients suggest increased nmda receptor signalling conducted proof concept study assess whether vivo evidence inverse association depression schizophrenia respect nmda receptor function purpose used translational approach based findings animal studies nmda receptor key mediator arginine vasopressin avp release bloodstream using hypertonic saline increase plasma osmolality osm thereby induce avp release done animal studies found depressed patients nmda receptor mediated avp release induced hypertonic saline infusion significantly increased pgml mosmol compared schizophrenia patients pgml mosmol slopes healthy control subjects pgml mosmol less depressed group findings consistent implicated nmda receptor related abnormalities depression schizophrenia subgroups patients provide first vivo evidence dichotomy
labor markets become increasingly global competition among industrialized nations attract highly skilled workers abroad intensified spurred concerns future economic needs caused demographic challenges aging population japan sweden joined global competition article examines japanese swedish immigration policies highly skilled migrants compares highly skilled migrants experiences two countries interviews migrants despite japan sweden completely different approaches immigration countries policies well experiences skilled migrants strikingly similar highly skilled migrants experience language barriers prejudice countries making difficult build social networks natives career development seems perceived common problem although less sweden labor markets flexible overall issues reduce japan sweden ability retain skilled migrants share similarities sweden famed work life balance gender equality give edge competition skilled migrants japan share comparison identifies social conditions facilitate impede skilled migrant settlement
gut microbiome diverse host specific symbiotic bacterial environment critical mammalian survival exerts surprising yet powerful influence brain behavior gut dysbiosis linked wide range physical psychological disorders including autism spectrum disorders anxiety well autoimmune inflammatory disorders wealth information effects dysbiosis anxiety depression reported laboratory model systems germ free mice however effects microbiome disruption social behaviors aggression non model species may particularly important understanding many aspects physiology behavior yet fully explored assessed sex specific effects broad spectrum antibiotic gut microbiome effects social behaviors male female siberian hamsters phodopus sungorus experiment administered broad spectrum antibiotic short term basis found antibiotic treatment altered microbial communities gut male female hamsters experiment tested effects single versus repeated antibiotic treatment including recovery phase behavior found two one treatments caused marked decreases aggressive behavior social behaviors males aggression returned normal levels following recovery antibiotic treated females contrast showed decreased aggression single treatment social behaviors unaffected unlike males female aggression return normal either recovery period present findings demonstrate modest antibiotic treatment results marked disruption gut microbiome hamsters akin research done rodent species humans show treatment broad spectrum antibiotic dysbiotic effects also robust sex specific effects aggression critical behavior survival reproductive success many rodent species elsevier inc rights reserved
structural testing existing pavement overlay design using conventional sampling laboratory testing expensive time consuming also difficult task contrast nondestructive testing using equipment portable dynamic cone penetrometers dcps falling weight deflectometers defectographs used investigate structural capacity different layer materials design rehabilitation strategies pavement consequently extensive ndt program carried pakistan unbound granular material using dcp paper presents empirical relationship dcps california bearing ratio cbr testing road base sub base materials using relationship cbr values calculated using knowledge layer strength materials based dcp values
microbial colonization gastrointestinal tract essential process modulates host physiology immunity recently researchers begun understand microorganisms colonize gut early life factors impact natural ecological establishment vertical transmission maternal microbes offspring critical factor host immune metabolic development increasing evidence also points role wiring gut brain axis process may altered various factors mode delivery gestational age birth use antibiotics early life infant feeding hygiene practices fac early exposures impact intestinal microbiota associated development diseases obesity type diabetes asthma allergies even neurodevelopmental disorders present review summarizes impact cesarean birth gut microbiome health status developing infant discusses possible preventative restorative strategies compensate early life microbial perturbations
experience maltreatment childhood associated chronic low grade inflammation adulthood however molecular mechanisms underlying pro inflammatory phenotype remain unclear mitochondria recently found principally coordinate inflammatory processes via inflammasome activation inflammasome independent pathways end hypothesized alterations immune cell mitochondrial functioning oxidative stress might interface association maltreatment experiences childhood inflammation analyzed pro inflammatory biomarkers levels reactive protein cytokine secretion peripheral blood mononuclear cells pbmc vitro pbmc composition lysophosphatidylcholine levels serum oxidative stress levels arginine citrulline ratio carnitine acetylcarnitine levels mitochondrial functioning respiratory activity density mitochondria pbmc peripheral blood samples collected women aged years varying degrees maltreatment experiences form abuse neglect childhood exposure maltreatment childhood associated increased ros production higher levels oxidative stress increased mitochondria activity dose response relationship moreover increase mitochondrial activity ros production positively associated release pro inflammatory cytokines pbmc decreased serum levels lysophosphatidylcholines suggested higher inflammasome activation increasing severity child maltreatment experiences together findings offer preliminary evidence association alterations immune cell mitochondrial functioning oxidative stress pro inflammatory phenotype observed individuals history maltreatment childhood results emphasize early prevention child abuse neglect warrants attention experience maltreatment childhood might life long consequences physical health elsevier mitochondria research society rights reserved
setting national institute research tuberculosis madurai india objective determine efficacy physician advice quitting smoking compared standard counselling patients tuberculosis patients human immunodeficiency virus hiv infection design methods clinical trial conducted madurai south india among male patients hiv randomised stratified nicotine dependence low high according fagerstrm scale received physician advice standard counselling standard counselling alone smoking cessation abstinence month assessed self report carbon monoxide breath analysis results patients mean age years overall patients high nicotine dependence patients smoked cigarettes bidis combined analysis including hiv groups quit rates patients physician group patients standard counselling arm conclusions physician advice quit smoking delivered patients hiv feasible acceptable smoking cessation could easily initiated patients programme settings future studies assess longterm abstinence rates larger sample size demonstrate efficacy physician advice
growing popularity massively accessed web applications store analyze large amounts data facebook twitter google search prominent examples applications posed new requirements greatly challenge traditional rdbms response reality new way creating manipulating data stores known nosql databases arisen paper reviews implementations nosql databases order provide understanding current tools uses first nosql databases compared traditional rdbms important concepts explained databases allowing persist data distribute along different computing nodes within scope review moreover nosql databases divided different types key value wide column document orierited graph oriented case comparison available databases carried based important features elsevier ltd rights reserved
social cognition epistemological understanding promote elementary school children experimentation skills investigate question children ages grades assessed experimentation skills social cognition advanced theory mind atom epistemological understanding understanding nature science general information processing skills inhibition intelligence language abilities whole class testing procedure multiple indicators multiple causes model revealed significant influence social cognition atom epistemological understanding mcnemar test suggested children development atom important precursor emergence advanced mature epistemological understanding children epistemological understanding turn predicted experimentation skills importantly relation independent common influences general information processing significant relations experimentation skills inhibition epistemological understanding intelligence language abilities emerged suggesting general information processing contributes conceptual development involved scientific thinking model scientific thinking tested study social cognition epistemological understanding promote experimentation skills fitted data significantly better alternative models assumed nonspecific equally strong relations constructs investigation results support conclusion social cognition plays foundational role emergence children epistemological understanding turn closely related development experimentation skills findings significant implications teaching scientific thinking elementary school stress importance children epistemological understanding scientific thinking processes
objectives study examined factors associated nurses willingness care patients infected human immunodeficiency virus hiv hepatitis virus hbv hcv vietnam methods cross section vietnamese nurses two hospitals selected using stratified random sampling self administered questionnaire administered included demographic items previous experience patients infected hiv hbv hcv attitudes toward patients data analyzed using descriptive statistics multiple logistic regression results lifetime prevalence needlestick sharps injury whilst caring patient infected hiv hbv hcv respectively majority participants expressed willingness care patients infected hiv hbv hcv willingness care hiv infected patients positively associated years age confidence protecting infection regarding hbv hcv infection willingness care positively associated individual confidence protecting infection conclusions study revealed vietnamese nurses somewhat willing care patients infected hiv hbv hcv associated individual confidence protecting infection negative attitudes towards hiv hbv hcv establishing positive safety culture providing appropriate professional education help reduce stigma towards infected patients offers effective way forwards improve quality care vietnam elsewhere
aim current study map landslide susceptibility ziarat watershed golestan province iran using maximum entropy machine learning model two sampling strategies mahalanobis distance memd random sampling mers aim total landslides watershed recorded point features using gps global positioning system device along several field surveys available local data reviewing landslide related studies using principal component analysis landslide controlling factors chosen namely altitude slope percent slope aspect lithological formations proximity faults streams roads land use cover precipitation plan profile curvature state ofthe art topo hydrological factor known height nearest drainage hand two sampling methods used divide landslides two sets training test area success rate curve ausrc area prediction rate curve auprc used evaluate results memd mers results showed memd mers strategies respective ausrc values good performance modelling landslide susceptibility study area however auprc test showed slightly different results memd value showed excellent predictive power comparison mers auprc value higher auprc value relation ausrc indicated memd premier model current study according memd three landslide controlling factors including lithological formations proximity roads precipitation respective contribution percentages contained information relation rest moreover according one one factor removal test lithological formations proximity faults identified unique information compared rest according memd study area located within high high susceptibility classes matter great interest decision makers local authorities formulating land use planning strategies implementing pragmatic measures elsevier rights reserved
aim evaluate quality accuracy websites written public inflammatory bowel disease ibd crohn disease ulcerative colitis assess readability level methods google bing yahoo search engines searched independently three researchers december english language websites selected basis predetermined inclusion exclusion criteria researchers independently evaluated quality website using discern honcode instruments readability levels calculated using two formulas flesch kincaid grade level index coleman liau readability index agreement evaluators calculated using cohen kappa coefficient results eighty four websites finally identified scores varied minimum discern score maximum mean median interquartile range interquartile range iqr minimum score honcode maximum mean median iqr websites reviewed creators websites universities research centers foundations associations commercial pharmaceutical companies charities volunteer work non university educational bodies flesch kincaid grade level readability score mean coleman liau readability index score significant correlation found two readability scores overall agreement evaluators measured cohen kappa coefficient range rated good conclusion discern honcode scores websites varied readability levels websites public readability level study highlights areas need improvement development patient education online materials ibd
induced earthquakes often accompany fluid injection seismic hazard pose threatens various underground engineering projects models monitor control induced seismic hazard traffic light systems probabilistic forward looking updated new data arrive study propose induced seismicity test bench test rank models test bench used model development model selection ensemble model building apply test bench data basel soultz sous forets geothermal stimulation projects assess forecasts two models shapiro smoothed seismicity sass hydraulics seismics hysei models incorporate different mix physics based elements stochastic representation induced sequences results show neither model fully superior generally hysei forecasts seismicity rate better shut mediocre forecasting spatial distribution hand sass forecasts spatial distribution better gives better seismicity rate estimates shut shut phase difficult moment models reservoirs models tend underpredict seismicity rate around shortly shut
paper outlines low cost user friendly photogrammetric technique nonmetric cameras obtain excavation site digital sequence images based photogrammetry computer vision digital camera calibration automatic aerial triangulation image feature extraction image sequence matching dense digital differential rectification used combined certain number global control points excavation site reconstruct high precision measured three dimensional models using acrobatic figurines qin shi huang mausoleum excavation example method solves problems little base height ratio high inclination unstable altitudes significant ground elevation changes affecting image matching compared laser scanning color point cloud obtained method maintain visual result advantages low project cost simple data processing high accuracy structure motion sfm often used reconstruct models large scenes lower accuracy reconstructed model small scene close range results indicate method quickly achieves reconstruction large archaeological sites produces heritage site distribution orthophotos providing scientific basis accurate location cultural relics archaeological excavations investigation site protection planning proposed method comprehensive application value spie
remedy problems riddled cancer chemotherapy poor solubility low selectivity insufficient intra cellular release drugs novel heparin based redox sensitive polymeric nanoparticles developed amphiphilic polymer heparin alpha tocopherol succinate hep cys tos synthesized grafting hydrophobic tos heparin using cystamine redox sensitive linker could self assemble nanoparticles phosphate buffer saline pbs low critical aggregation concentration cac values ranging paclitaxel ptx loaded hep cys tos nanoparticles prepared via dialysis method exhibiting high drug loading efficiency physicochemical properties optimized formulation characterized dynamic light scattering dls transmission electron microscope tem differential scanning calorimetry dsc subsequently redox sensitivity hep cys tos nanoparticles confirmed changes size distribution morphology appearance dithiothreitol dtt treatment besides vitro release ptx hep cys tos nanoparticles also exhibited redox triggered profile also uptake behavior pathways coumarin loaded hep cys tos nanoparticles investigated suggesting nanoparticles could taken mcf cells energy dependent caveolae mediated cholesterol dependent endocytosis manners later mtt assays different ptx free ptx loaded formulations revealed desirable safety ptx free nanoparticles enhanced anti cancer activity
skin reactions known adverse effects radiation therapy despite advances skin care products still demand optimal skin care products improve therapy lesions authors report use polylactide based copolymer suprathel polymedics innovations gmbh denkendorf germany temporary skin substitute covering skin defects patient moist desquamation due radiation
recent decades studies based questionnaires interviews concluded doctors become ill face significant barriers seeking help several reasons proposed primarily notion doctors work environment predisposes inappropriate help seeking behaviour article idea ill physician paradox medical drama examined text interpretive comparative approach historical illness narratives written doctors suffering one specific diagnosis namely opioid addiction complex set considerations guiding behaviour patients extent revealed article concludes identity transition necessary become patient doctors held back professional status every step assist needs take shape based awareness underlying principles medical drama written illness narratives doctors highlighted article might serve tool increase awareness
wearable cardioverter defibrillator wcd used temporary protection patients deemed high risk sudden death scd yet meeting indications implantable defibrillator icd evaluate efficacy safety compliance wcd use subsequent medium term outcome patients single center observational study total consecutive patients fitted wcd followed mean months months common clinical indication wcd prescription new diagnosis severely impaired function lvef median wear time wcd days daily use appropriate wcd therapy occurred four patients seven shocks one shock icd finally implanted patients improvement function common reason implant icd two patients inappropriate shocks wcd due atrial fibrillation flutter five patients fitted icd end wcd therapy suffered episodes wearing wcd six patients died five icd recipients one non icd recipient wcd therapy well accepted patients provided temporary protection ventricular tachyarrhythmias patients risk scd wcd may help avoid unnecessary icd implantations significant proportion patients
amino acids present great potential heavy metals sorption thanks active chemical groups tyrosine amino acid containing amine carboxylate phenol groups thus potential candidate heavy metals remediation however biomolecule water soluble difficult remove tyrosine metal complexes water potential solution would consist grafting biomolecule onto material ensure good separation heavy metals trapped tyrosine grafted material water medium thus grafting tyrosine onto polypropylene nonwoven carried evidence grafting tyrosine given several characterization techniques fourier transform infrared spectroscopy ray photoelectron spectroscopy tyrosine grafting rate obtained sorption efficiency tyrosine functionalized material evaluated flame atomic absorption spectrometry degrees approximately copper per gram trapped confirming good efficiency tyrosine interesting result study constant sorption capacity whatever sodium chloride concentration copper sulfate solution result specific tyrosine allows considering possibility use material marine wastewaters sediments depollution article contains supporting information made available online issue published
eif alpha protein plays critical role regulation translation production double stranded rna dsrna viral replication activate protein kinase pkr phosphorylates eif alpha leading inhibition initial step translation many viruses evolved gene products targeting pkr eif alpha pathway indicating importance antiviral defense present study focused alternations pkr eifa pathway human herpesvirus hhv infection monitoring viral gene expression infectious viral yields found increased phosphorylated pkr well phosphorylated eif alpha coincident accumulation late viral protein level total pkr relatively constant decreased postinfection phosphorylation eifa led moderate increase activating transcription factor atf accumulation indicating moderate inhibition protein translation hhv infection overexpression pkr led decreased viral propagation coincident increased accumulation phosphorylated pkr phosphorylated eifa moreover addition dominant negative pkr mutant resulted moderate increase viral replication hhv exhibits relatively low efficiency propagation progeny virus secreted culture medium study suggests replicative strategy hhv involves mild infection lengthy life cycle culture preventing severe activation pkr eif alpha pathway importance human herpesvirus hhv hhv common widely prevalent viruses causing mild severe disease study focused pkr eif alpha stress pathway limits viral replication hhv genome carries multiple genes transcribed two strands predicting accumulation dsrnas activate pkr inhibition protein synthesis report hhv induced accumulation phosphorylated pkr phosphorylated eif alpha moderate increase activating transcription factor atf known transcribe stress genes overexpression pkr led increased eif alpha phosphorylation decreased viral replication whereas overexpression dominant negative pkr mutant resulted moderate increase viral replication results suggest hhv replication strategy involves restricted activation pkr eif alpha pathway partial translation inhibition lower yields infectious virus essence hhv limits replication due inability bypass eif alpha phosphorylation
efficacy placing copper intrauterine device iud emergency contraception prevent pregnancy depend menstrual cycle timing timing unprotected intercourse upi urine pregnancy test negative prior iud placement copper iud highly effective point menstrual cycle use copper encouraged failure oral methods decrease rates unintended pregnancy documented success iud reducing unintended pregnancies however scant data exist regarding efficacy safety iud insertion accounting menstrual cycle timing time since upi secondary analysis data obtained previously published prospective cohort study women received copper iud july january included participants according study inclusion criteria known last menstrual period lmp cycle lengths days original study included women aged years presented sites throughout china regular menstrual cycles days known lmp upi within days negative urine pregnancy test cutoff women uncertain lmp dates excluded study included participants cycle lengths days among participants usual cycle lengths days iud inserted following upi expected fertile window insertion days predicted ovulation day insertion days upi pregnancies first month among women information available regarding month follow pregnancy test secondary analysis observational study thus participants randomized alternative postcoital method small number women upi days predicted ovulation day thus limiting confidence assuring low risk pregnancy situation ovulation day calculated based lmp prior iud insertion subsequent first day menses following iud insertion urine pregnancy test negative prior iud placement copper iud likely effective almost point menstrual cycle original study funded undp unpfa world bank special programme research development research training human reproduction donors sponsors study role study design data collection data analysis data interpretation writing report decision submit paper publication
aimto investigate suppression endogenous testosterone week strength training period influences activity satellite cells myonuclei methodstwenty two moderately trained young men participated randomized placebo controlled double blinded intervention study participants randomized treatment gnrh analogue goserelin suppresses testosterone placebo weeks strength training period weeks started weeks treatment included exercises major muscles biopsies obtained mid portion vastus lateralis muscle resultstestosterone resting level goserelin times lower compared placebo training induced increase level testosterone abolished goserelin training increased satellite cells number type fibres placebo goserelin whereas myonuclear number significantly increased type fibres placebo remained unchanged goserelin changes satellite cells myonuclei seen type fibres either group data microarray analysis indicated low testosterone affects bone morphogenetic proteins signalling might regulate proliferation differentiation satellite cells conclusioneight weeks strength training enhances myonuclear number type fibres largely blocked suppression testosterone data indicate low testosterone levels could reduce differentiation satellite cells myonuclei via bone morphogenetic proteins signalling pathway resulting reduced increases lean leg mass
paper proposes new relaxation based circuit simulation algorithm called backward traversing waveform relaxation btwr btwr employs brand new strategy simulate simulates performing depth first search signal flow graph simulated circuits major advantage btwr ability flexibly schedule subcircuits calculating according subcircuits converging situations enables btwr act robustly well efficiently dealing various types circuits simulation demand sod function also constructed btwr proposed methods implemented tested simulating various circuits
aspergillus fumigatus main etiologic agent causing invasive aspergillosis induce inflammatory response prothrombotic phenotype upon contact human umbilical vein endothelial cells huvecs however fungal molecules involved endothelial response remain unknown fumigatus hyphae produce extracellular matrix composed galactomannan galactosaminogalactan alpha glucan study investigated consequences ugm gene deletion fumigatus produces mutant increased galactosaminogalactan production delta ugm mutant exhibited huvec hyperadhesive phenotype induced increased endothelial tnf alpha secretion tissue factor mrna overexpression semiprofessional immune host cell using shotgun proteomics approach show fumigatus delta ugm strain modulate levels proteins important endothelial pathways related inflammatory response mediated tnf stress response pathways furthermore purified galactosaminogalactan fraction also able induce tnf secretion coincident huvec pathways regulated delta ugm mutant overexpresses component demonstrated fluorescence microscopy work contributes new data regarding endothelial mechanisms response fumigatus infection significance invasive aspergillosis main opportunistic fungal infection described neutropenic hematologic patients one important clinical aspect invasive fungal infection vascular thrombosis could related least part activation endothelial cells shown previous reports group known direct contact fumigatus hyphal cell wall huvec cell surface necessary induce endothelial prothrombotic phenotype secretion pro inflammatory cytokines though cell surface components angioinvasive fungus trigger endothelial response unknown present work employs discovery driven proteomics approach reveal role one important cell wall polysaccharide fumigatus galactosaminogalactan huvec interaction consequent mechanisms endothelial activation first report overall panel proteins related huvec response specific purified cell wall component angioinvasive fungus fumigatus elsevier rights reserved
background large amount research devoted detection investigation epistatic interactions genome wide association studies gwass literature focuses low order interactions single nucleotide polymorphisms snps significant main effects results paper propose original approach detecting epistasis gene level without systematically filtering significant genes first compute interaction variables gene pair finding eigen epistasis component defined linear combination gene snps highest correlation phenotype selection significant effects done using penalized regression method based group lasso controlling false discovery rate conclusion method tested two recent alternative proposals literature using synthetic data shows good performances different settings demonstrate power approach detecting new gene gene interactions three genome wide association studies
learners second language increasingly interacting small groups part communicative methodological paradigm studies investigated social dynamics occur groups aim study introduce group work dynamic measuring instrument investigate relationship group work dynamic gwd social climate existing within group learners state level motivational responses amount language produced interactive tasks context classroom based study speaking skills course consisting small group korean english learners intermediate high intermediate proficiency level enrolled korean university tesol certificate program data based different tasks part course two work groups task total groups instruments data collection consisted audio video recordings transcription verbal nonverbal language produced tasks gwd measurement instrument post task motivation questionnaires results correlational analysis showed significant relationship gwd task motivation gwd language production nonverbal related behaviors furthermore found particularly influential shaping gwd significantly associated learners task motivation especially form greater task enjoyment sense success study findings therefore add support socio contextual perspectives motivation applied linguistics emphasize critical role social group factors motivation language development imply need educators focus creating positive group dynamics classrooms
objective authors group recently published novel technique navigation guided frameless stereotactic approach placement depth electrodes epilepsy patients improve accuracy trajectory enhance procedural workflow authors implemented isys miniature robotic device present study routine methods first step preclinical phantom study performed using human skull model accuracy timing electrodes implanted manual technique aid robot compared phantom study showed increased accuracy robot assisted electrode placement confirmed robot ability maintain stability despite rotational forces leverage effect drilling screwing patients enrolled analyzed robot assisted depth electrode placement authors institution january december procedures performed surgical navigation system synergy cranial software isys miniature robotic device results ninety three electrodes implanted patients median age years range years females males authors saw significant increase accuracy compared manual technique median deviation planned entry target points range range respectively last patients electrodes series authors modified technique placing guide implantation depth electrodes gide bone saw significant increase accuracy entry point mean compared first patients median length trajectories range mean duration depth electrode placement start trajectory alignment fixation electrode minutes range minutes significantly faster manual technique patients depth electrode placement combined subdural electrode placement procedure well tolerated patients authors encounter case hemorrhage neurological deficit related electrode placement patient psoriasis vulgaris superficial wound infection encountered adequate physiological recordings obtained electrodes additional electrodes implanted misplacement conclusions isys robotic device versatile easy use tool frameless implantation depth electrodes treatment epilepsy increased accuracy authors manual technique entry point target enhanced expedited authors procedural workflow
compared rating scales different manic symptom items diagnostic accuracy detecting pediatric bipolar spectrum disorder bpsds outpatient mental health clinics participants parents guardians eligible children male mean age completed parent general behavior inventory item mania pgbi mania subscale child adolescent symptom inventory revised casi diagnoses based ksads interviews parent youth receiver operating characteristic roc analyses diagnostic likelihood ratios dlrs determined discriminative validity provided clinical utility respectively logistic regressions tested incremental validity casi mania subscale pgbi predicting youth bpsd status beyond demographic common diagnostic comorbidities casi pgbi scales significantly distinguished bpsd disorders casi area curve auc pgbi auc diagnostic likelihood ratios indicated low scores either scale casi pgbi cut bpsd odds high scores casi dlr pgbi dlr high scores either scale casi pgbi increased bpsd odds fourfold casi dlr pgbi dlr logistic regressions indicated casi mania subscale pgbi provided incremental validity predicting youth bpsd status casi least valid pgbi help identify bpsds considered part assessment battery screen pediatric bpsds
magnesium silicide mgsi one attractive promising green thermo electric material convert heat electricity mid temperature range degrees however synthesizing mgsi compound liquid solid state processing carries several challenges processing time inhomogenous stoichiometry phase purity alternative method demonstrated rapid situ synthesis pure nano crystalline mgsi doped spark plasma sintering sps xrd electron microscopy studies confirm formation mgsi compound eds confirm chemical doping homogeneity superior power factor achieved degrees elsevier rights reserved
south mexico traditionally faced disproportionate social health economic disadvantage relative rest country due part lower levels economic human development barriers faced indigenous populations state oaxaca particular one highest proportions indigenous people consistently displays high rates maternal mortality sexually transmitted infections teenage pregnancy study examines social values norms surrounding sexuality changed two generations women living indigenous communities oaxaca conducted semi structured depth interviews women two generational cohorts communities comparison views two cohorts suggest cultural gender norms continue govern women express experience sexuality particular feelings shame fear permeate expression sexuality virginity continues determinant woman worth motherhood remains key attribute womanhood evidence points transformation norms access information services related sexual health increasing nonetheless still need culturally appropriate sex education programmes focused female empowerment increased access sexual health services reduction stigma surrounding women expressions sexuality resumecomparativement reste pays sud mexique est traditionnellement confronte maniere disproportionnee des handicaps sociaux sanitaires economiques partiellement raison plus faibles niveaux developpement economique humain obstacles divers rencontres par les populations indigenes etat oaxaca particulier une des plus fortes proportions populations indigenes presente constamment des taux eleves mortalite maternelle infections sexuellement transmissibles grossesse adolescence cette etude examine comment les valeurs les normes sociales concernant sexualite ont change entre deux generations femmes vivant dans des communautes indigenes oaxaca nous avons conduit des entretiens profondeur semi structures avec femmes issues deux cohortes generationnelles reparties sur communautes les vues comparatives sur ces deux cohortes suggerent que les normes genre culturelles continuent encadrer maniere dont les femmes expriment vivent leur sexualite les sentiments honte peur notamment impregnent expression sexualite virginite continue etre determinante dans valeur une femme maternite demeure caracteristique cle feminite des elements probants indiquent une transformation des normes acces information aux services concernant sante sexuelle est plus plus important neanmoins reste necessaire mettre place des programmes fois axes sur autonomisation des femmes elargissement acces aux services sante sexuelle diminution stigma qui entoure expression sexualite par les femmes adaptes aux particularites culturelles ces femmes resumenel sur mexico sufrido tradicionalmente desventajas sociales sanitarias economicas desproporcionadas comparacion con resto del pais debido parte los niveles mas bajos desarrollo economico humano los obstaculos que padece poblacion indigena concreto estado oaxaca tiene uno los porcentajes mas altos poblacion indigena presenta constantemente altas tasas mortalidad materna infecciones transmision sexual embarazos adolescentes este estudio analizamos como han cambiado los valores sociales las normas sobre sexualidad dos generaciones mujeres que viven comunidades indigenas oaxaca llevamos cabo entrevistas semiestructuradas exhaustivas con mujeres dos cohortes generacionales comunidades las opiniones comparativas estas dos cohortes indican que las normas genero culturales siguen dictando como expresan viven las mujeres sexualidad particular los sentimientos verguenza temor definen expresion sexualidad virginidad considera todavia determinante del valor una mujer maternidad sigue siendo atributo clave feminidad evidencia senala que las normas estan cambiando esta aumentando acceso informacion los servicios relacionados con salud sexual sin embargo todavia son necesarios programas educacion sexual culturalmente apropiados que centren autonomia las mujeres mayor acceso los servicios salud sexual una reduccion del estigma con respecto las expresiones sexualidad las mujeres
session initiation protocol sip widely used authentication protocol voice communications years several protocols proposed literature strengthen security sip paper present efficient elliptic curve cryptography ecc based provably secure three factor authentication session key agreement scheme sip uses identity password personal biometrics user three factors scheme aims resolve security weaknesses drawbacks existing sip authentication protocols addition scheme supports password biometric update phase without involving server user mobile device revocation phase case mobile device lost stolen formal security analysis standard model broadly accepted burrows abadi needham logic ensures proposed scheme withstand several known security attacks proposed scheme also analyzed informally simulation formal security verification using widely known automated validation internet security protocols applications tool shows replay man middle attacks protected scheme high security low communication computation costs make proposed scheme suitable practical application compared existing related ecc based schemes copyright john wiley sons ltd
background pressure ulcers associated substantial health burden could preventable hospital acquired pressure ulcers hapus prevention become priority healthcare settings considered sign quality care providing intensive care unit icu patients higher risk hapus development despite availability published prevention strategies little evidence strategies safely integrated routine standard care impact hapus prevention aims aim synthesize best available evidence regarding effectiveness single strategies designed reduce incidence prevalence hapus development icus methods search strategy designed retrieve studies published english across cinahl medline cochrane central register controlled trials embase scopus mednar adult icu participants aged years review included randomized controlled trials quasi experimental comparative studies studies selected retrieval assessed two independent reviewers methodological validity prior inclusion review using standardized critical appraisal instruments results review included studies meta analysis revealed statistically significant effect silicon foam dressing strategy reducing hapus incidence effect size effect size respectively critically ill patients evidence effectiveness nutrition skin care regimen positioning repositioning schedule support surfaces role education prevention hapus development icu limited precludes strong conclusions linking evidence action review provides evidence based guide future priorities clinical practice particular silicone foam dressing positive impact reducing sacrum heel hapus incidence icu
rainwater harvesting might help achieve self sufficiency must comply health standards studied runoff quantity quality harvested seven urban surfaces university campus barcelona according use pedestrian motorized mobility materials concrete asphalt slabs experimental rainwater harvesting system used collect runoff resulting set rainfall events estimated runoff coefficient initial abstraction surface analyzed physicochemical microbiological properties hydrocarbon metal content samples rainfall intensity surface material state conservation essential parameters low rainfall intensity surface degradation runoff coefficient variable minimum concrete best quality whereas weathering particulate matter deposition led worse quality asphalt areas physicochemical runoff quality outstanding compared superficial underground water microorganisms identified samples cfu treatment required meet human consumption standards motorized traffic mostly affects presence metals zinc future sustainable mobility patterns might result improved rainwater quality standards elsevier ltd rights reserved
objectives aspergillosis common fungal infection among solid organ transplant recipients even awareness infection occurs still gaps nonculture diagnostic tests delay treatment initiation aimed define common traits pulmonary aspergillosis infection among solid organ transplant recipients thus shedding light prevention early diagnosis materials methods conducted database search patients baskent university positive aspergillosis culture january march among patients identified mean age female male patients solid organ transplant included study results study patients heart transplant kidney transplant liver transplant recipients three patients positive aspergillosis cultures extrapulmonary specimens brain biopsy wound swap cultures patients positive cultures broncho alveolar lavage patients sputum patients bronchoalveolar lavage sputum patient deep tracheal aspiration specimen patient aspergillus fumigatus common species mean hospitalization duration days range although patients positive culture results patients negative galacto mannan test results time culture specimen collection positive galactomannan test results statistically higher heart transplant patients patients fever presentation patients referred pulmonary disease department positive culture results obtained conclusions risk factors pulmonary aspergillosis clinical presentation solid organ transplant recipients still unclear although expected time aspergillosis infection solid organ transplant recipients months transplant clinicians must remember nonspecific presentation infections patients aware reliability diagnostic tools
installed capacity solar photovoltaic small size wind turbine residential microgrid gains promising growth developed countries however uncertain characteristic intermittence volatility still one significant factors affect effective operation well conducted design distributed renewable resources considering household requirement reliability energy utilization implicit behavior meteorological uncertainty managed stochastic time series weather data satisfy objectives planning hybrid renewable generation system installed residential customers load management strategies conducted improve energy utilization green building renewable power planning stage proposed simulation framework realizes optimal installed capacity residential renewable generation storage device achieve effective energy utilization future green building
hand gestures form nonverbal communication allow person communicate range thoughts feelings without speech mems axis accelerometer detect input gestures direction axis detect four types gesture includes left right hand motion data collected directly send microcontroller run help wireless module thedata compressed different users gesture extract sign sequence template matching single gesture contain numbers code code reduces hundreds data values single gesture also compare stored templates paper three models introduced discussed accuracy sequence gesture contain experiments finally results achieves overall accuracy based sign sequence generation template matching recognitioncontains ranging
new york stories aims research represent realms inner expression constitute people lived experiences urban space remain beneath surface public activity capacity complex inner lifeworld consisting inner speech inchoate trajectories thought unarticulated moods random urges unsymbolised thinking imagination sensation memory distinctive feature human experience mediates many realms everyday life action practice placing problem interiority directly field turning ethnographic practice based question addressed collaboration informants new york stories seen ethnographic attempt research represent everyday experience living hiv aids new york lower east side examining complex trajectories thinking played public spaces necessarily externalised
growing interest computational models visual attention saliency prediction become important research topic computer vision past years many different successful saliency models proposed especially image saliency prediction however models generally consider dynamic nature scenes hence work better static images date relatively little work dynamic saliency deals predicting humans look videos addition previous studies showed feature integration carried crucial accurate results yet many dynamic saliency models follow similar simple design extract separate spatial temporal saliency maps integrated together obtain final saliency map paper present comparative study different feature integration strategies dynamic saliency estimation employ number low high level visual features static saliency motion faces humans text previously used dynamic saliency estimation order explore strength feature integration strategies investigate four learning based svm gradient boosting nnls random forest two transformation based mean max fusion methods resulting six new dynamic saliency models experimental analysis two different dynamic saliency benchmark datasets reveal models achieve better performance individual features addition learning based models outperform state art dynamic saliency models
background influenza virus infections associated wide spectrum disease however studies investigated detail epidemiological virological characteristics asymptomatic mild illness influenza virus infections methods community based study hong kong followed initially healthy individuals household contacts symptomatic persons laboratory confirmed influenza identify secondary infections information daily symptom diaries used classify infections symptomatic signs symptoms including fever degrees headache myalgia cough sore throat runny nose sputum paucisymptomatic symptom asymptomatic none symptoms compared patterns influenza viral shedding groups results identified virologically confirmed secondary cases influenza virus infection household setting including paucisymptomatic asymptomatic cases duration viral rna shedding shorter declined rapidly paucisymptomatic asymptomatic symptomatic cases mean levels influenza viral rna shedding asymptomatic paucisymptomatic cases approximately log copies lower symptomatic cases conclusions presence influenza viral shedding patients influenza symptoms reflects potential transmitting virus close contacts findings suggest research needed investigate contribution persons asymptomatic clinically mild influenza virus infections influenza virus transmission household institutional community settings
popular south african herbal tea honeybush made several cyclopia species family fabaceae amongst cyclopia genistoides phytoestrogenic potential genistoides recently reported however bioactivity guided isolation compounds estrogenic activity yet performed transgenic plant system arabidopsis thaliana per gus used assay estrogen like activity genistoides quantitative determination active compounds fermented non fermented plant material performed hplc subsequent bioactivity guided fractionation led isolation genistein naringenin isoliquiritigenin luteolin helichrysin tetrahydroxyflavanone four first reported genus helichrysin naringenin tetrahydroxyflavanone differed quantity fermented unfer mented herbs fermented plant material contained two compounds substantial estrogenic like activity higher concentration naringenin tetrahydroxyflavanone whereas less active helichrysin abundant unfermented herb fractions well compounds inhibited growth human cancer cell lines results underline phytoestrogenic activity genistoides support rationale fermentation process saab published elsevier rights reserved
eucard aims research rebco superconducting magnets future accelerator applications properties rebco conductors different low temperature superconductors investigate dynamic field quality stability normal zone propagation electrical network model coated conductor cables developed validate model two identical samples prepared cern measurements taken university twente southampton university model predicts roebel cable changing magnetic field applied perpendicular direction hysteresis loss much larger coupling loss case changing magnetic field applied parallel cable coupling loss dominant first case experiment good agreement model second case data compared qualitatively calibration inductive measurement available
generating discriminative input features key requirement achieving highly accurate classifiers process generating features raw data known feature engineering take significant manual effort paper propose automated feature engineering derive suite additional features given set basic features aim improving classifier accuracy discriminative features assist data scientists automation implementation specific http computer network traffic measure effectiveness proposal compare performance supervised machine learning classifier built automated feature engineering versus one using human guided features classifier addresses problem computer network security namely detection http tunnels use bro process network traffic base features apply automated feature engineering calculate larger set derived features derived features calculated without favour base feature include entropy length grams string features counts averages time numeric features feature selection used find relevant subset features testing showed classifiers achieved detection rate false positive rate datasets conclude automated feature engineering provide advantages increasing classifier development speed reducing development technical difficulties removal manual feature engineering achieved also maintaining classification accuracy crown copyright published elsevier ltd rights reserved
daily dialogue leaders workers traditional construction sites primarily focused production quality time issues rarely involves occupational safety health osh issues leadership training program entitled toolbox training developed improve construction foremen knowledge communication skills daily planning work tasks related osh risks construction sites program builds popular toolbox meeting concept however little research evaluating types meetings article describes development implementation feasibility toolbox training program results process evaluation outcome evaluation total foremen companies participated training five successive groups following group program continuously evaluated revised final version fifth group evaluation utilized action research strategy mixed methods approach triangulating questionnaire interview observation data process evaluation results showed eight toolbox training topics relevant useful majority foremen experienced positive changes daily work methods interactions crews colleagues leaders customers construction professions program unique contribution leadership training construction industry potentially applied adapted many sectors however still need testing long term effects program safety climate injuries business future studies authors published elsevier ltd
paper presents multi role project method mrp broadly applicable project based learning method describes implementation evaluation context science technology engineering mathematics stem course mrp method designed around meta principle considers project learning activity role playing game based two projects learning project engineering project meta principle complemented five principles provide framework guide working practices student teams distribution responsibilities regular interactions solicitations within team anticipation continuous improvement positive interdependence alternating individual collective work open communication content management paper presents implementation mrp course teaching software engineering uml language project management results show mrp helped course students acquire important professional knowledge skills experience near real world professional realities develop abilities work teams autonomously
objectives investigate impact training modification achieving performance goals previous research demonstrates inverse relationship injury burden success team sports unknown whether relationship exists within individual sport athletics design prospective cohort study international track field athletes athlete seasons across five international competition seasons methods athlete training status recorded weekly year period month preparation season relationships training weeks completed number injury illness events success failure performance goal major championships investigated two two table constructed attributable risks exposed afe calculated mixed model logistic regression used determine relationship failure burden per injury illness receiver operator curve roc analysis performed ascertain optimal threshold training week completion maximise chance success results likelihood achieving performance goal increased times completed planned training weeks auc training availability accounted successful seasons afe majority new injuries occurred within first month preparation season illnesses occurred within months event every modified training week chance success significantly reduced conclusions injuries illnesses influence training availability preparation major determinants athlete chance performance goal success failure international level sports medicine australia published elsevier ltd rights reserved
consider weighted means spaces alpha beta gamma duals duality spaces visualized three dimensional real space representing norm potential surface dual norm corresponding wulff crystal
correlates bacterial vaginosis poorly understood especially hiv infection cohort study hiv seropositive comparison seronegative women assessed every months considered present three four amsel criteria met behavioral characteristics assessed using structured interviews multivariable logistic regression used generalized estimating equation models determine factors associated cumulative incidence time assessed using log rank test among women hiv seronegative hiv seropositive contributing visits diagnosed visits hiv seronegative women visits hiv seropositive women cumulative incidence hiv seronegative women seropositive women adjusted analyses factors associated younger age ethnicity lower income less education recruitment site recruitment cohort heavier drinking current smoking depression sex male partner hormonal contraception menopause negatively associated women prevalent recurred within year persistent found participants neither proportion differed hiv serostatus time trends proportion women single visit identified common among women risk hiv hiv infection predispose associated instead behavioral cultural factors
background considerable evidence outcome expectations may predict psychotherapy outcomes however little known long term outcome expectations following end treatment aims aim study evaluate patients long term outcome expectations trauma focused post traumatic stress disorder ptsd psychotherapy single group effectiveness study methods twenty participants various traumatic experiences completed brief eclectic psychotherapy post traumatic stress disorder bepp assessments included study self report measures used evaluate therapeutic outcomes impact event scale revised ies clinical outcomes routine evaluation outcome measure core pre treatment post treatment month follow subjective units distress scale used measure long term outcome expectations post treatment asking participants measure expected distress months following treatment assessments month follow used estimate accuracy patients expectations distress previous post treatment assessment results significant decline ptsd symptoms post treatment large effect sizes observed post treatment assessment participants expected significant improvement condition months treatment however therapeutic effects remained stable month follow conclusion concluded ptsd patients even successful trauma focused treatment tend expect significant positive changes however therapeutic effects stable half year psychotherapy patients tend false expectations improvement condition
mechanism aerostatic torsional divergence atd long span suspension bridges investigated theoretical analysis basis generalized model presented showing vertical motion bridge deck crucial torsional stiffness whole suspended system vertical motion either cable magnitude beyond certain threshold could result sudden degradation torsional stiffness system vertical motion induced degradation stiffness recognized main reason atd long span suspension bridges susceptible type divergence especially immersed turbulent wind fields divergences occur turbulent wind fields differ significantly smooth wind fields difference well explained generalized model loosening one cable could result vanishing part stiffness provided whole cable system mechanism revealed paper leads definition critical wind speed atd turbulent flow one resulting vertical motion large loosen either cable stressless state numerical results nonlinear finite element analysis xihoumen suspension bridge conjunction observations wind tunnel tests aero elastic full bridge model support viewpoint presented study elsevier ltd rights reserved
objective study evaluate new way applying bed baths reducing risk dry skin comparing effect two washing methods skin hydration cluster randomized trial conducted skin hydration measured implementation disposable wash gloves using moisturemeter three skin sites total skin hydration differ residents start study groups implementation post minus pre hydration scores higher intervention group control group skin sites however difference significant cheek site use disposable wash gloves increase risk dry skin comparison traditional washing methods results may encourage introduction disposable wash gloves innovation daily skin care practice elsevier inc rights reserved
objectiveto test association recall socially rewarding positive socially critical negative information depressive symptoms methodcohort study people visited primary care past year reporting depressive symptoms female positive negative recall assessed three time points weeks apart using computerised task depressive symptoms assessed four time points using beck depression inventory bdi analyses conducted using multilevel models resultsconcurrently found evidence every increase two positive words recalled depressive symptoms reduced bdi points association affected adjustment confounders evidence association negative recall depressive symptoms longitudinally found evidence positive recall associated reduced depressive symptoms vice versa conclusionpeople severe depressive symptoms recall less positive information even recall negative information unaltered clinicians could put emphasis encouraging patients recall positive socially rewarding information rather trying change negative interpretations events already occurred
introduction ulipristal acetate upa selective progesterone receptor modulator sprm sprms new class progesterone receptor ligands exert tissue selective agonist antagonist mixed agonist antagonist activity target cells upa inhibits proliferation induces apoptosis leiomyoma cells vitro demonstrates potent progesterone antagonist activity vitro vivo areas covered manuscript aims review available data safety upa treatment uterine fibroids data articles included manuscript obtained via pubmed medline embase november expert opinion upa efficacious treatment uterine fibroids surgery decreases leiomyoma volume uterine bleeding furthermore improves quality life short term administration upa shown safe short follow months associated minimal adverse side effects studies longer follow required define safety profile upa endometrial histology
background intramedullary spinal cord tumors imsct account tumors central nervous system surgical resection continues effective treatment modality intramedullary tumors gross total resection leading preserved neurologic function improved survival however surgical treatment often difficult carries significant risk postoperative neurologic complications intraoperative neuromonitoring shown clinical importance surgical resection imsct main monitoring modalities include somatosensory evoked potentials transcranial motor evoked potentials via limb muscles spinal epidural space waves dorsal column mapping monitoring modalities shown inform surgeons intraoperatively many cases led alterations operative decision methods reviewed literature usefulness intraoperative neuromonitoring intramedullary spinal tumor resection role predicting postoperative neurologic deficits medline search performed studies reviewed detailed information data selected articles assessed compiled data extracted showing role monitoring outcomes surgery conclusions using intraoperative somatosensory evoked potentials transcranial motor evoked potentials waves dorsal column mapping spinal injury could prevented cases thereby improving postoperative neurologic functioning outcome patients undergoing surgery imsct
paper develops model cancer screening cancer incidence data accommodating partially unobserved disease status clustered data structures general covariate effects dependence exams true unobserved cancer detection status screening participants treated latent variables markov chain monte carlo algorithm used estimate bayesian posterior distributions diagnostic error rates disease prevalence show bayesian approach used draw inferences screening exam properties disease prevalence allowing possibility conditional dependence two exams techniques applied estimation diagnostic accuracy mammography clinical breast examination using data ontario breast screening program canada copyright johnwiley sons ltd
study employed homogeneous heterogeneous panel methods examine relationship renewable non renewable electricity consumption economic development three transition economies baltic region namely estonia latvia lithuania period study put forward four hypotheses examine renewable electricity development nexus findings indicated existed unidirectional causality economic development renewable electricity consumption thus results obtained statistical analyses provided empirical evidence support conservation hypothesis postulates economic development causes expansion renewable electricity consumption vice versa
highly superior autobiographical memory hsam recently identified ability difficult explain existing memory science present study measured hsam participants age gender matched controls number behavioural measures test three main hypotheses imaginative absorption emotional arousal sleep hsam participants significantly higher controls dispositions absorption fantasy proneness two dispositions also associated measure hsam ability within hyperthymesia participants emotional arousal hypothesis yielded weak support sleep hypothesis supported terms quantity sleep quality may small factor worthy research individual differences also documented using predominantly exploratory analysis speculative pathways describing tendencies absorb fantasise could lead enhanced autobiographical memory discussed
act violence parents raising safe kids program act prsk interactive violence prevention program developed american psychological association parents young children program teaches supports parents areas child development roots consequences violence anger management adults children social problem solving positive discipline impact media violence children ninety two parents caregivers young children participated study effects program parenting behaviors first participants assigned intervention group completed act prsk program remaining parents caregivers served comparisons results indicated reduced spanking reduced rate hitting children objects act prsk participants furthermore act prsk group evidenced improved knowledge behaviors beliefs regarding violence prevention parenting results provide support efficacy brief intervention preventing child maltreatment
electrocoagulation effective electrochemical approach treatment different types contaminated water received considerable attention recent years due high efficiency dealing numerous stubborn pollutants successful dealing organic inorganic contaminants negligible almost generation product wastes past decade vast amount research devoted utilizing electrocoagulation treatment several types wastewater ranging polluted groundwater highly contaminated refinery wastewater paper offers comprehensive review recent literature dedicated utilizing electrocoagulation water treatment focusing current successes specific applications water wastewater treatment well potentials future applications paper examines aspects theory potential applications current challenges recent developments well economical concerns associated technology recent research focusing pollutant specific evaluation without paying attention cell design process modeling industrial applications review attempts highlight main achievements area outlines major shortcomings recommendations promising research options enhance technology broaden range applications elsevier ltd rights reserved
work presents experimental investigation small scale range organic rankine cycle system net electrical power output ability using low grade waste heat steam system designed waste steam range bar organic rankine cycle system designed thermodynamic simulation performed equipment selection construction test rig carried rfa used working fluid scroll type expansion directly coupled electrical generator produced maximum electrical power output net electrical power output thermal efficiency system net efficiency expander isentropic efficiency maximum power output operation point maximum thermal efficiency maximum expander isentropic efficiency obtained experiment effect superheating working fluid expander inlet also investigated show increase degree superheating degrees reduces thermal efficiency system current system results indicated measured electric power output enthalpy determined power output accounting isentropic efficiency differed similarly screw pump converted electric power enthalpy determined pumping power delivered working fluid expander screw pump losing power electric mechanical losses generator motor presenting need development components better efficiency heat loss piping also factor improving efficiency along ability heat exchangers control system maintain least possible degree superheat working fluid expander inlet elsevier ltd rights reserved
present study aimed elucidating gross morphology morphometry biometry major salivary glands buffalo different prenatal well neonatal stages study conducted major salivary glands twenty four buffalo foetuses well six neonatal buffalo calves three pairs major salivary glands viz parotid mandibular sublingual distinguished prenatal neonatal life buffalo mandibular gland largest among three major salivary glands prenatal buffalo may attributed early development among salivary glands sublingual gland smallest among three major salivary glands prenatal buffalo measured half size mandibular gland cvrl day mandibular gland began form epithelial outgrowth mesenchyme forming floor mouth linguo gingival groove cvrl day sublingual gland arose number small epithelial thickenings linguogingival groove thickening formed canal grossly superior polystomatic inferior monostomatic parts sublingual gland distinguishable cvrl day cvrl day parotid gland seen form small rod extending dorsally lateral part oral cavity infront external ear behind facial nerve significant differences biometrical parameters major salivary glands foetuses group iii well neonatal buffalo observed level
paper presents translinear topology suitable static dynamic analog signal processing low supply voltage one variable objective functions piece wise linear approximated finally implemented using cmos translinear networks use functions offers advantage small computational time implementations controllable errors good stability topology used structural synthesis program automated synthesis translinear circuits
propose classical analog electromagnetically induced transparency cylindrical waveguide undulated metallic walls transparency induced multi mode interactions waveguides narrow line width also consists single second order transverse mode corresponds bessel function distributions investigated extensively due unique characteristics increasing thickness sputtered gold layers waveguide demonstrate frequency agile single mode transparency phenomenon terahertz radiation found center frequency transparency linearly related gold thickness indicating achievement controllable single mode terahertz device field distributions cross sections outlets verify single second mode transparency indicate mechanism frequency manipulation significantly benefit mode control engineering terahertz applications elsevier rights reserved
study provides timely flexible location aware service las mobile users dynamic environment previous studies examined similar concepts proposed methodology inaccuracy user positioning uncertainty manual service preparation considered modeled using fuzzy numbers numbers used inputs establish fuzzy integer nonlinear programming model applied identifying suitable service location path required service prepared immediately user reaches recommended service location manage simultaneous requests multiple users concepts fuzzy modeling route planning parallel machine scheduling combined thus proposed las distribute multiple users among service locations thereby enabling users avoid unnecessary waiting major problem associated existing lass assess effectiveness proposed methodology two experiments conducted small areas taichung city taipei city taiwan experimental results revealed waiting times users substantially reduced increasing average satisfaction level however improving accuracy user positioning necessarily facilitate achieving high average satisfaction level elsevier rights reserved
green building core content human habitat construction wind environment nitrogen oxides motor vehicle emissions urban community tianjin city simulated based rng epsilon turbulence pollutant dispersion models three evaluation indices proposed according regulatory requirements green building air quality standard china satisfaction regulatory requirements urban community evaluated condition typical wind different seasons results showed proposed evaluation indices used satisfaction evaluation green buildings
offshore cultivation seaweed provides innovative feedstock biobased products supporting blue growth northern europe paper analyzes two alternative exploitation pathways energy protein production first pathway based anaerobic digestion seaweed converted biogas production electricity heat digestate used fertilizer second pathway uses seaweed hydrolysate substrate cultivation heterotrophic microalgae result seaweed sugars consumed new proteins produced enhancing total output performed comparative life cycle assessment five scenarios identifying critical features affecting resource efficiency environmental performance systems aim providing decision support design future industrial scale production processes results show scenarios provide environmental benefits terms mitigation climate change biogas production dried laminaria digitata favorable scenario quantified scenario presents also lowest consumption total cumulative energy demand even resulting net reduction fossil energy fraction compared situation without seaweed cultivation scenarios provide mitigation marine eutrophication thanks bioextraction nitrogen phosphorus seaweed growth material consumption seeded lines times higher impact human toxicity cancer reduction achieved energy protein substitution however minor changes cultivation design use stones instead iron ballast weight seeded lines dramatically reduces human toxicity cancer externalities use digestate fertilizer affect human toxicity non cancer due transfer arsenic aquatic environment agricultural soil however concentration heavy metals digestate exceed limit established danish regulation assessment identifies seaweed productivity key parameter improve performance production systems promising service provider environmental restoration climate change mitigation elsevier ltd rights reserved
urbanization brings economic social benefits also causes water pollution environmental ecological problems paper provides theoretical framework quantitatively analyze dynamic relationship water resource utilization process urbanization using data jiangsu province first construct indices evaluate urbanization water resource utilization adopt entropy model examine correlation urbanization water resource utilization addition introduce dynamic coupling model analyze predict coupling degree urbanization water resource utilization analyses show pairing rising urbanization overall index water resource utilization jiangsu province experienced decline rise decline trend specifically index water resource utilization reached lowest point gradually began rise water resource utilization reached highest value coupling degree urbanization water resource utilization relatively low varying degrees degrees rising since sample forecasts indicate coupling degree reach highest value degrees start gradually decline jiangsu province chosen studied area one selected pilot provinces china economic reform social development analysis relationship provincial water resource utilization urbanization essential understanding dynamic relationship two systems also serves important input developing national policies sustainable urbanization water resource management
background early detection neurodegenerative diseases essential treatment proper care patients screening tools available today effective several types dementia however one specific lewy body dementia lbd objectives aim paper present tool early detection lbd accessible even nonmedical staff methods stratified subjects mmse four groups health controls mild cognitive impairment mci lbd dementias alzheimer vascular subjects age range examined comprehensive neuropsychological neuropsychiatric evaluation well neuroimaging differentiate diagnosis groups fulfilling corresponding criteria neurologists neuropsychologists blind performance clinical evaluations asi respectively sensitivity specificity instrument determined differentiate lbd groups results evaluated subjects mci dementia dementia group diagnosed lbd dementias asi total score lbd mci causes dementia roc curve analysis showed sensitivity specificity stands cutoff better test performance compared groups conclusion asi brief screening tool lbd high sensitivity specificity useful even non medical staff elsevier rights reserved
background binge eating marker weight gain obesity hallmark feature eating disorders yet component constructs overeating loss control loc eating poorly understood difficult measure objective objective study critically review human literature concerning validity loc overeating across age weight spectrum data sources english language articles addressing face convergent discriminant predictive validity loc overeating included results loss control overeating appear adequate face validity emerging evidence supports convergent predictive validity loc construct given unique cross sectional prospective associations numerous anthropometric psychosocial eating behaviour related factors overeating may best conceptualized marker excess weight status limitations binge eating constructs particularly context subjectively large episodes challenging measure reliably studies addressed overeating absence loc thereby limiting conclusions validity overeating construct independent loc additional studies addressing discriminant validity constructs warranted discussion suggestions future weight related research appropriately defining binge eating eating disorders diagnostic scheme presented
compensatory exercise fasting behavior absence binge eating purging appear important eating disorder behaviors associated dysfunction little known behaviors youth studied trajectories development non binge eating non purging girls early adolescence using longitudinal design assessed girls six times three years middle school grades developed trajectories specifying different developmental patterns relation behaviors prior period girls grade elementary school assessed risk factors predict girls subsequent trajectory group membership compensatory exercise trajectory groups included non engagement group group increased behavior group decreased behavior two fasting trajectory groups one consistently engaging behavior consistently elementary school levels depression eating expectancies thinness expectancies predicted subsequent trajectory group membership risk compensatory exercise fasting evaluated early grade targeted interventions focus girls late elementary school middle school appears critical developmental maintenance period compensatory exercise fasting behavior elsevier ltd rights reserved
variety studies food sharing elucidate ultimate proximate functions non human primates especially pan chimpanzees food sharing serves means strengthen social relationships contrast little known food sharing orangutans since semi solitary lifestyle barely provides opportunity share food outside mother offspring context however recent long term studies suggest social bonding might play important role orangutans previously assumed zoos orangutans often kept groups seem cope group living quite well captive orangutans use food sharing social tool expected share food frequently selectively close social partners engage frequently active transfers provided three orangutan groups monopolizable food recorded dyadic food related interactions dyad determined relationship quality tested whether predicts food sharing found support predictions almost two thirds interactions involving food resulted sharing probability individual share food particular partner increased strength relationship exceeding expectations food sharing occurred even individuals two neighboring groups finally comparison studies captive chimpanzees revealed significantly higher proportion active transfers orangutans suggesting species specific sharing psychologies sharing food universal prosocial behavior humans recent research aims elucidate adaptive functions proximate mechanisms comparison species especially non human primates natural captive settings bonobos chimpanzees closest relatives quality social relationships revealed important food sharing contrast limited knowledge food sharing orangutans distant semi solitary living hominid relatives study provides first systematic investigation food sharing patterns role relationship quality captive orangutans results demonstrate group living orangutans share frequently selectively close associates even actively found chimpanzees findings add evidence supporting hypothesis social bonding played role evolution human prosocial behavior
non adherence persistence adjuvant endocrine therapy negatively impact survival beliefs medicines known affect adherence study aims identify socio demographic clinical characteristics associated medication beliefs among women taking aromatase inhibitors ais women completed online survey beliefs therapy beliefs medicines questionnaire bmq beliefs breast cancer assessment survivor concerns scale asc depression personal health questionnaire depression scale phq socio demographic clinical characteristics collected bivariate analyses linear regression models performed investigate relationships variables total women reported currently taking therapy included analysis significantly higher concern beliefs found among women least mild depression experienced side effects ais previously stopped therapy another significant correlations found concern necessity beliefs cancer health worry women age older displayed less fear cancer recurrence health worry trend towards lower necessity concern beliefs differences found variables regression model greater necessity beliefs found increases number current prescription medications shorter duration current therapy whereas greater concern beliefs associated higher depression scores medication necessity concern beliefs associated definable subset patients may higher risk non persistence
increased market demand composite products shortage expert laminators compelling composite industry explore ways acquire layup skills experts transfer novices eventually machines lack holistic methods literature capturing composite layup skills especially involving complex moulds research aims develop informatics based method enabled consumer grade gaming technology machine learning capture digitise manufacturing task knowledge skill intensive hand layup digitisation underpinned proposed human workpiece interaction theory implemented automatically extract decode key knowledge constituents layup strategies ply manipulation techniques motion mechanics problem solving hand layup collectively categorised layup skills significance research potential facilitate cost effective transfer skills experts novices real time automated supervision hand layup automation layup tasks future authors published elsevier ltd open access article license
inception indian jute industry jute fiber proved superiority fibers particularly area packaging food grains terms functionality reusability due considerable tensile strength low extensibility good dimensional stability obviously natural choice packaging one growing alternatives today context emergence technical textiles made natural fibers includes geotextile products geotechnical applications agrotextile products well relevant areas jute geotextile certainly considered potential aspirant replacing majority today popular synthetic products posing severe threats environment thereby adversely affecting eco congruity application jute fabrics different types sites even designing garments apparel sector observed ability fabric assume graceful appearance contour crucial conveying significance drapeability jute fabric attempt made paper study effect relevant property parameters comparative analysis drapeability jute fabric well synthetic woven nonwoven fabrics respect end use requirements
development solar energy conversion production fuels water splitting water purification systems become important sidestep traditional fossil energy herein investigated coupling effect photo fenton system conventional photocatalytic reaction novel doped hybrid structure decomposition nitrophenol selected model reaction context degradation organic pollutants heterojunction nanocomposites consisting nanosheets nanoparticles shown facilitate separation photo induced electron hole pairs photocatalytic activity maximized result synergism photo fenton cycle iii doping presence generate additional hydroxyl radicals result visible light degradation nitrophenol could remarkably enhanced compared reference best knowledge first time striking increase reported photo fenton system applied present photocatalytic system significance presence hydroxyl radicals photo fenton performance doped assessed scavenger fluorescence tests additional light shed reaction mechanism via spin trapping enabled situ electron paramagnetic resonance elsevier rights reserved
health services research uses increasingly data health insurance funds well known funds differ regard sociodemographic characteristics morbidity uncertain also differences prevalence musculoskeletal disorders compare sociodemographic characteristics various health insurance funds prevalence joint disorders chronic back pain wave german socioeconomic panel served database average age sex distribution nationality education employment status evaluated according health insurance funds prevalence joint disorders chronic back pain also stratified according insurance funds standardized according age sex total participants included participants insured aok followed bkk barmer gek huge differences among health insurance funds regard sociodemographic characteristics example proportion unemployed insurants ikk aok prevalence joint disorders standardized according age sex pkv aok prevalence chronic back pain pkv aok differences prevalence musculoskeletal disorders among health insurance funds extrapolation analyses one health insurance fund german population thus limited
paper introduces adaptive slope compensation method digital clamping current control various input voltages improve power factor total harmonic distortion thd universal input controller conducts phase management mechanism various input voltages load conditions raise circuit conversion efficiency optimal switching timing one two phase operations determined power loss distribution digital signal processor chip tmsf used implement digital platform laboratory prototype universal line voltage output voltage designed tested verify feasibility values efficiency light load rated power full load inputs greater values medium full load greater input current harmonics also meet norm iec class
objective establish injury profile soccer players first division brazilian soccer team addition investigated association characteristics injuries player age position method forty eight players brazilian first division soccer team followed one season descriptive statistics used characterize injury profile spearman tests used verify association number severity injuries player age chi square test used verify association type injury player position fisher exact test used verify association severity injuries player position results incidence injuries hours matches hours training injury severity days competition training lower limb common location injury injuries muscular tendinous overuse non recurrent non contact injuries player age correlated amount severity muscle tendon injuries defenders minimal injuries days lost forwards moderate days lost severe injuries days lost furthermore wingbacks muscle tendon injuries midfielders joint ligament injuries conclusion injury profile brazilian players investigated study reflected regional differences soccer practices results confirm influence player age position soccer injuries profile
twenty first century rapid advances made electric propulsion vehicles countermeasure global warming addition emissions vehicles stringently regulated thus automakers around world develop hybrid electric vehicles also conventional internal combustion engine energy saving technology battery technology ion semiconductor technology sic gan automotive power supply systems proceeded mass production stage verband der automobilindustrie german oems suppliers announced adoption market paper analyze needs impact compare current technology also try portray future view automotive power supply systems
rodents removal olfactory bulbs obs olfactory bulbectomy obx results numerous alterations neurotransmitter endocrine immune systems well behavioral changes similar observed depressed patients behavioral deficits induced obx animals reversed repeated administration antidepressants model often used test effectiveness putative antidepressant agents recent evidence suggests obx results dysfunction various cellular processes within hippocampus including decreases dentate gyrus neurogenesis disruption long term potentiation subregions neuronal atrophy subregion along downstream markers consistent abnormal neuronal activity hippocampus clinically depressed populations moreover repeated administration novel natural synthetic antidepressant compounds improve certain aspects depression like behavior hippocampal function effort bring together existing literature review focus mechanisms proposed pharmaceuticals impact hippocampal dependent processes behavior elsevier rights reserved
research examined group membership diminishes attribution mind individuals found mind attribution inversely related size group individual belonged experiment mind attribution affected group membership rather total number entities perceived experiment moreover mind attribution individual varied perception individual group member participants attributed mind individual appeared distinct distant group members individual perceived similar proximal cohesive group experiments effect occurred human nonhuman targets driven perception target entitative group member rather knowledge target entitative group member experiment elsevier inc rights reserved
many computer vision problems involve exploring synthesis classification models map images observed source space target space recently one popular effective method transform images source target space shared single sparse domain synthesis model established motivated technique research attempts explore effective robust linear function maps sparse representatio images source space target space simultaneously develop linear classifier coupled space supervised semi supervised learning order capture sparse structure shared class represent mapping using linear transformation constraint sparsity performance proposed method evaluated several benchmark image datasets low resolution faces digits classification super resolution experimental results verify effectiveness proposed method
interest know whether green building design communicate green messages occupants lead pro environmental behaviours distinctive power building elements visual objects use visual persuasion studied context green buildings preliminary survey carried melbourne council house results showed potential using green building design persuasion tool influence occupants pro environmental behaviours finding ensured necessity future full study extract effectiveness visual green building design persuading occupants behave pro environmentally building level effects due occupants awareness perception green design individual level hierarchical regression model bayesian inference proposed tested fake data simulation
network control strategies energy efficient operation hetnets need match dynamics spatial temporal traffic loads stabilize network paper develop stochastic optimization framework formulates spatially inhomogeneous traffic distributions time varyingly random traffic arrivals guarantees network stability investigate energy conservation problem hetnets particular jointly optimize base station operation user association subcarrier assignment power allocation minimize average energy consumption devise algorithm without requiring prior knowledge traffic distributions referred steerable energy expenditure algorithm seed solve problem deal highly coupled mixed combinational subproblem seed separate optimization variables suboptimal cost efficient easy implement algorithm design develop closed form solutions user association subcarrier assignment fast tuning free algorithm provably achieves least local optimality power allocation greedy style heuristic algorithm operation polynomial complexity simulation results exhibit seed usually converges fast flexibly tune power delay tradeoff significantly reduce energy consumption existing schemes
automation agricultural mapping using satellite derived remotely sensed data remains challenge africa heterogeneous fragmental landscape complex crop cycles limited access local knowledge currently consistent continent wide routine cropland mapping africa exist studies focused either certain portions continent one time effort mapping continent coarse resolution remote sensing research addressed limitations applying automated cropland mapping algorithm acma captures extensive knowledge croplands africa available ground based training samples high sub meter five meter resolution imagery vhri local knowledge captured field visits sourced country reports literature study used day time series moderate resolution imaging spectroradiometer modis normalized difference vegetation index ndvi composited data resolution entire african continent based data study first produced accurate reference cropland layers rcls cropland extent areas irrigation versus rainfed cropping intensities crop dominance croplands versus cropland fallows year provided overall accuracy around crop extent different agro ecological zones aezs rcls year rcl used development acma algorithm create acma derived cropland layers acl acl compared pixel pixel rcl overall similarity greater based acl african continent mha net cropland areas mha cultivated plus mha fallows mha gross cropland areas mha net cropland areas cultivated mha rainfed mha irrigated africa world population world irrigation net cropland area distribution mha season mha season mha continuous rainfed irrigated single crops net cropland area without cropland fallows cropped either season january may season june september acma algorithm deployed google earth engine gee cloud computing platform applied modis time series data obtain acma derived cropland layers years acl acl results indicated twelve years average croplands increased mha cropland fallows decreased mha year cropland areas computed acl african countries largely underestimated compared independent source census based cropland data root mean square error rmse mha acma demonstrated ability hind cast past years cast present year forecast future years cropland products using modis time series data rapidly currently insufficient reference data exist rigorously report trends results authors published elsevier behalf international society photogrammetry remote sensing inc isprs
foreign real time operating systems widely used last years russia developed aircraft well russian integrated modular avionics ima research projects presently question substitution russian analogues arisen article provides requirements operating system satisfy order used civil aviation analysis existing foreign domestic rtos aspects operating system development process published elsevier open access article license
speed control surface mounted permanent magnet synchronous motor spmsm based takagi sugeno fuzzy models designed implemented paper motor drive speed control proportional integral controller generally applied however tracking performance load regulation capability compromised designing process controller study develops speed controller based fuzzy model good tracking ability load variation regulation first dynamic model spmsm demonstrated load torque variation treated disturbances accordingly speed control strategy developed based fuzzy model defuzzification process parallel distributed compensation introduced ability disturbance suppression lyapunov stability system established analyzed controller gains obtained via linear matrix inequality toolbox speed control essential procedures realized microcontroller renesas rxt tracking performance load regulation capability verified experimental results
children participating research like children may maltreated also potential exposure abuse research research training practices protocols respond disclosure discovery abuse protect researchers children may sufficiently robust aim compare contrast research practices reported literature related protecting children recommend safer ways conduct research simultaneous increase research children along increased willingness listen child victims abuse means researchers must consider protection children research setting twenty three papers identified literature review studies reported wide variation ethical considerations methods methodology came different disciplines papers two overarching themes identified social justice research safer research make research safer teams consider training safety protocols support child protection includes support report safeguarding concerns social care work required ensure training protocols support effective facilitating researchers identify make appropriate child abuse referrals ethics practices abuse research need debate
paper define new graph theoretic cyclicity index natural generalization global cyclicity index arbitrary resistances allocated edge electrical network upper lower bounds provided using powerful technique based majorization extends prior studies bianchi discrete appl math doi dam bianchi math inequal appl new results weighted majorization interest may applied also scenarios
research aimed developing algorithms construction automated systems control active components electrical network construction automated systems intended control electric power systems requires high speed mathematical tools method applied research describe object control based universal approach mathematical modelling nonlinear dynamic system black box type represented volterra polynomials degree makes possible input output characteristics object obtain adequate fast mathematical description results computational experiment demonstrate applicability mathematical tool control active components intelligent power system
real numbermodeling analog circuits hardware description languages hdls become common part mixed signal soc validation propose two methods improve fidelity simulation speed make event driven piecewise linear pwl analog functional models easier write first use accuracy set users dynamically determine new output segment emitted computed without iteration capability allows designers trade accuracy simulation speed analog models without time consuming model calibration error estimation creates models generate events needed maintain output accuracy next extend method eliminate limit cycle oscillations occur simulating circuits continuous time feedback discrete time event simulator handling feedback efficiently allows user create system model simpler component models performance modeling approach demonstrated various analog filter models operational amplifier high speed wireline transceiver system faster optimally chosen fixed time step simulation transceiver
process oriented guided inquiry learning pogil student centered pedagogy extensively used chemistry curriculum use engineering limited paper describes use pogil introduction materials engineering course assessment effectiveness shows details implementation play critical role particular student centered aspect approach students feel taught thus take ownership learning providing opportunities students check understanding reflect learning process performance enhanced traditional lecture course published elsevier ltd selection peer review responsibility centre engineering education universiti teknologi malaysia
cryptography used protect content information message making undecipherable behaviors opposed information may encrypted may protected partially fully hiding creation ambiguity providing covers generate indistinguishable observations secrets cover together partial observability cause ambiguity system behaviors desired kept secret yet information secrets may still leaked due statistical difference occurrence probabilities secrets covers paper propose jensen shannon divergence jsd based measure quantify secrecy loss systems modeled partially observed stochastic discrete event systems quantifies statistical difference two distributions one observations generated secret generated cover show proposed jsd measure secrecy loss equivalent mutual information distributions possible observations possible system status secret versus cover since adversary likely discriminate observes longer period goal evaluate worst case loss secrecy obtained limit longer longer observations computation proposed measure also presented illustrative examples including one side channel attack provided demonstrate proposed computation approach note practitioners secrecy ability hide private information communicated information done encryption access control however possible system behaviors contrast cover introduced providing ambiguity quantifying ability hide secrets challenge paper provides means quantify terms type distance measure secret cover computation also provided partially observed stochastic discrete event systems illustrated cache side channel secrecy loss example
measurement observation chaotic system states major challenge control engineering due lack availability states control purpose fails realize required performance paper new observer based structure proposed control chaos recently developed rise feedback controller combined adaptive neural observer control genesio tesi chaotic system unlike conventional structures neural network applied observer trained line performance proposed controller investigated simulation
paper intends describe phenomenon observed children aged years old yet received formal instruction division tried solve problem distribution means drawings phenomenon called frames meaning attempts explain children successful solving problems others illustrate hypothesis empirically case study hypothesis powerful theoretical methodological tool understanding underlying mathematical thinking arithmetic problem solving abilities children age however necessary continue expand analysis application framework would lead reconsider conventional educational evaluative practices article try point way changes could made
computational thinking ability important computer science education emphasizes abstraction automation automation programming become key ability digital society recently result increase importance coding education many countries brought various educational methods improve teenagers programming abilities among programming abilities reading ability important especially programming novices paper focuses effects gender abstract thinking abilities adolescents understanding computer programs also examine difference teaching adolescents college students order achieve research goals surveyed abstract thinking level measured program understanding ability academic high school students learned language research found abstract thinking affects complex program understanding positively also found language experience learning brought difference program understanding however could find statistical differences program understanding two genders research provide new point view improve adolescents programming ability abstract thinking gender factors
treatment rainwater typically performed diversion first flush use strainers retain gross particles leaves date lack rainwater treatment systems high efficiency remove small suspended particles simple operation without energy consumption associated greenhouse gas emissions objective work develop test novel concept filtration particles raw rainwater energy usage self cleaning mechanism simple installation operation buildings purpose innovative concept developed based flow filtration flow backwashing operation concept tested building prototype treatment efficiency particle removal well backwash efficiency assessed three different filter media results showed system designed proposed concept operated effectively correct selection filter medium therefore proposed rainwater treatment concept offers opportunity enhance water security treating using rainwater buildings efficient simple energy free way elsevier rights reserved
previously reported higher education protects executive dysfunction related higher body mass index bmi younger older adults extend previous analyses verbal nonverbal memory fifty nine healthy dementia free community dwelling adults ranging age years completed hopkins verbal learning test revised hvlt brief visuospatial memory test revised bvmt self reported years education served proxy cognitive reserve found highly educated individuals maintained bvmt immediate recall performance across range bmi less educated individuals higher bmi associated worse performance findings suggest education may play protective role bmi related nonverbal learning deficits similar previous reports verbal memory executive functioning results highlight importance considering educational background determining risk bmi related cognitive impairment clinical settings
natural streams characterized variation cross section geometry bed slope bed roughness hydraulic slope etc along channels resulting several interacting features riverine system including effects discharge changes geologic context sediment load etc quantitative qualitative assessment river flow dynamics requires sufficient knowledge hydraulics geophysical variables average flow condition theory expressed station hydraulic geometry ahg relations site specific power functions relating mean stream channel forms water depth top width flow velocity flow area discharge studied since establishing robust ahg relations requires pre assessment data quality means uncertainty analysis paper introduces recursive data filtering procedure find random systematic errors streamflow river survey data used produce robust informative ahg relations method first verified synthetic data experiments real discharge stage ratings provided daily streamflow records geological survey national water information system dataset usgs nwis field river survey measurement data usgs nwis produces robust ahg relations monitoring stations across elsevier rights reserved
purpose compare trends utilization rates imaging three hospital based settings imaging conducted methods nationwide medicare part databases used discretionary noninvasive diagnostic imaging ndi cpt codes selected grouped modality procedure volumes code available databases converted utilization rates per medicare enrollees medicare place service codes used identify imaging examinations done hospital inpatients hospital outpatient departments hopds emergency departments eds trends observed life study results trendlines strongly affected code bundling echocardiography nuclear imaging however even aside artifactual effects important trends could discerned inpatient imaging utilization rates modalities trending downward hopds utilization rate conventional radiographic examinations cres declining rates mri echocardiography noncardiac ultrasound increasing eds utilization rates cres increasing years code bundling occurred total inpatient ndi utilization rate dropped whereas rate eds increased hopds increased conclusions trends utilization ndi three hospital based settings imaging occurs distinctly different radiologists others involved deciding kinds equipment purchase locate cognizant trends making decisions american college radiology
low cost rodent model hiv infection presents high application value effective tool investigate hiv infection pathogenesis however development small animal model hampered unsuitability rodent cells hiv replication given retrovirus hiv high selectivity host cell study used mouse leukemia cell lines induced murine leukemia virus transfected hcd ccr loaded lentiviral vector lentiviral vectors containing genes hcd ccr transcriptional control cytomegalovirus promoter designed transfection efficiencies human ccr cells analyzed quantitative real time polymerase chain reaction pcr western blot assay results showed hcd ccr proteins expressed cell surface demonstrating cells humanized possess characteristics necessary hiv infection human host cells moreover sensitivity human ccr transgenic mouse cells hiv infection confirmed pcr elisa mouse leukemia cell lines could express hcd ccr thus established facilitate normal entry hiv human ccr transgenic mice cell model used investigate transmission pathogenesis hiv aids potential antiviral drugs disease
work explores benefits supporting learners affectively context aware learning situation features new challenge related literature terms providing affective educational recommendations take advantage ambient intelligence delivered actuators available environment thus going beyond previous approaches provided computer based recommendation present text tell aloud learner address open issue applied tormes elicitation methodology used investigate potential ambient intelligence making interactive recommendations emotionally challenging scenario preparing oral examination second language learning course arduino open source electronics prototyping platform used sense changes learners affective state deliver recommendation interactive way different complementary sensory communication channels sight hearing touch cope universal design ambient intelligence context aware affective recommender platform aicarp built support whole experience represents progress state art particular come likely first interactive context aware affective educational recommendation value contribution lies discussing methodological practical issues involved
objective recent research concluded barriers maternity health care exist lesbian bisexual queer women mixed methods study aims understand patterns seeking sharing online health information lbq women attempting conception design researchers performed qualitative content analysis discussions lesbian oriented facebook groups containing total instances text discussions heterosexual oriented conception parenting facebook groups examined comparison purposes though focus analysis paper also presents descriptive statistics posts observed setting posts drawn representative sample lesbian oriented conception pregnancy parenting facebook groups posts examined comparison purposes drawn groups appeared primarily serve heterosexual women measurements findings many participants lesbian oriented facebook groups sought provided medical information queries focused insemination process frequently related posters specific situations heterosexual women tended seek general advice conception pregnancy process accuracy content responses varied group members seemed view prevalence contradictory information positive evidence diverse perspectives even information technically correct posters always apply properly question hand key conclusions barriers maternity care lack education initiative among primary care providers may drive lesbian bisexual queer women seek health information peers internet trying become pregnant exchanges may contribute misinformation may negatively affect lesbian bisexual queer women fertility outcomes overall health implications practice clinicians conscious online health information seeking symptom cause sexuality based disparities
information indicating variations induced menstrual cycle may influence capacity young women respond stress physiological response stress changes across stages lifespan however spite great increase life expectancy way women react inenopause period characterized dramatic decline sex hormones sufficiently studied main objective study examine capacity respond recover acute social stressor post menopausal women compared young women second objective investigate consequences behavior self regulatory systems measured behavior cortisol dnd heart rate speaking task front committee sixty seven women post menopausal pre menopausal follicular group luteal group differences heart rate reactivity three groups found post menopausal women showed less cortisol reactivity stress also displayed higher percentage gestures speaking task reflecting clearer pattern active coping compared young women post menopausal women behaviors reflect active coping strategies related better autonomic regulation contrast pre menopausal women cortisol changes seemed modulated passive reactive behaviors submission assertion results emphasize importance considering age hormonal status coping processes including reactivity recovery stressful situations elsevier inc rights reserved
background cognitive empathy supported medial prefrontal cortex mpfc inferior frontal gyrus ifg anterior mid cingulate cortex amcc insula ins supplementary motor area sma right temporo parietal junction tpj precuneus prec healthy controls cortical thickness regions linked cognitive empathy cognitive empathy impaired schizophrenia examined whether reduced cortical thickness regions associated poorer cognitive empathy population methods clinically stable community dwelling individuals schizophrenia healthy controls group matched demographic variables completed self report empathy questionnaires cognitive empathy task structural magnetic resonance imaging examined group differences study variables using tests analyses variance next used pearson correlations evaluate relationship cognitive empathy cortical thickness mpfc ifg amcc ins sma tpj prec groups results individuals schizophrenia demonstrated cortical thinning ifg ins sma tpj prec impaired cognitive empathy across measures relative controls cortical thickness mpfc ifc amcc ins conclusions individuals schizophrenia reduced cortical thickness empathy related neural regions significant impairments cognitive empathy interestingly cortical thickness related cognitive empathy controls schizophrenia group discuss mechanisms may account cognitive empathy impairment schizophrenia elsevier rights reserved
study examines men interested fashion interpret fashion advertisements data garnered interviews adult men regularly read fashion magazines buy fashion clothing findings reveal men process fashion advertisements five modes women current study also demonstrates men responses fashion advertisements categorized fashion engagement grid examines men characterizations motivations fashion behavior study expands theoretical understandings gender advertising research recommends advertising elements attract male consumers
present study investigated whether cortisol stress responses year olds associated behavioral functioning school additionally moderating role stress family environment examined end healthy children age years girls participated age appropriate innovative social evaluative stress test saliva cortisol samples collected six times stress test calculate two indices cortisol stress response cortisol stress reactivity total stress cortisol teachers assessed children internalizing externalizing prosocial behaviors stress family environment operationalized maternally reported parenting stress results indicated significant increase cortisol concentrations response stressor significant associations found cortisol stress responses behavioral functioning school evidence moderation maternal parenting stress potential theoretical methodological explanations results discussed
objectivemen women mate preferences long term relationships extensively considered research however men women short term mate preferences received nearly much attention particular theoretical origins men women short term mate preferences received limited consideration comparison long term relationships specifically although evolutionary origins short term mate preferences discussed elements social economic theory socioeconomic status ses gender roles yet explored current study sought address gap literature concerning short term mate preferences social economic theory methodseven hundred eighty one participants recruited complete questionnaire included mate budget paradigm resultsfor men results showed significant independent effects ses gender roles short term mate physical attractiveness scores significant interaction results also showed significant main effect ses gender roles short term mate social level scores although significant interaction masculine gender role medium high ses women independent interactive effects ses gender roles physical attractiveness social level scores discussionresults interpreted relation evolutionary social economic theories specifically discussing strategic pluralism sexual strategies theories results study highlight need increased awareness independent interactional effects social economic theory elements men women short term mate preferences exploration relationships outside dichotomy long short term
posterior reversible encephalopathy syndrome pres reversible clinical neuroradiological syndrome may appear age characterized headache altered consciousness seizures cortical blindness exact incidence still unknown commonly identified causes include hypertensive encephalopathy eclampsia cytotoxic drugs vasogenic edema related subcortical white matter lesions hyperintense flair sequences relatively symmetrical pattern especially occipital parietal lobes detected cranial imaging findings tend resolve partially completely early diagnosis appropriate treatment present rare case unilateral pres developed following treatment pazopanib testicular tumor vascular endothelial growth factor vegf inhibitory agent
paper focuses development government microblog wechat mircovideo jilin province firstly status construction management utilization government microblog wechat mircovideo jilin province analyzed basis found exist many problems hindering development government platforms include small number government microblog wechat mircovideo accounts jilin province insufficient information government affairs inadequate publicity large number zombie accounts zombie followers fake fans poor interaction lack standardized management imperfect management team based exploration problems existing operation government microblog wechat mircovideo jilin province constructive corresponding suggestions put forward
introduction placental dysfunction characterized vascular endothelial inflammation one notable responses fetal cardiac bypass regulator calcineurin rcan important regulator inflammatory responses micrornas mirnas essential post transcriptional modulators gene expression mirna mir showed activate vascular endothelial inflammation hypothesized mir may key regulator placental dysfunction fetal cardiac bypass methods evaluated mirna expression goat placentas via small rna sequencing quantitative real time polymerase chain reaction qrt pcr situ hybridization expression mirna target genes determined via bioinformatics analyses dual luciferase reporter assays furthermore human umbilical vein endothelial cells huvecs transfected mir control sequence rcan nuclear factor activated cells nfatci nuclear factor kappa kappa levels huvecs placentas evaluated via western blot qrt pcr results demonstrated mir highly enriched goat placenta cardiopulmonary bypass moreover rcan identified novel direct target mir transfection mir led decreased rcan expression increased nfatci kappa expression huvecs conversely inhibition mir rescued rcan expression reduced nfatci kappa expression huvecs conclusions demonstrated remarkable role mir regulator nfatc associated placental inflammation direct targeting rcan mir could serve novel therapeutic target limiting progression placental inflammation fetal cardiac bypass authors published elsevier ltd
demand response defined shifting electricity demand generally believed value grid market matching demand closely supply consumers could profit lower prices smart grid environment renewable electricity used less grid capacity may needed however introduction residential demand response programmes support development smart grids includes renewable generation hampered number barriers paper reviews barriers categorises different demand programmes market players case study netherlands shows barriers country specific two types demand response programmes identified promising options households smart grids price based demand response direct load control may beneficial market players distribution system operators authors international journal energy research published john wiley sons ltd
past decades randomized trials examined effects psychological treatments adult depression article results series metaanalyses trials summarised several types psychotherapy examined including cognitive behaviour ther apy behavioural activation therapy interpersonal psychotherapy problem solving therapy nondirective supportive therapy short term psychodynamic psychotherapy therapies effective significant differences treatments psychotherapies equally effective pharmacotherapy combined treatments effective either alone therapies also effective specific target groups older adults college students patients general medical disorders may somewhat less effective chronic depression patients comorbid substance use disorders treatments effective delivered individual group guided selfhelp format effects psychotherapies overestimated low quality many trials due publication bias future research aimed development new psychotherapies depression specific treatment formats therapies specific populations evidence indicates types formats human involvement effective specific target groups future research instead focus reduction disease burden depression specifically focus possibilities preventing onset depressive disorders treatments chronic treatment resistant depression relapse prevention scaling treatments example using guided self help interventions
purpose across african continent many colleges universities facing hurdles sustaining green building initiatives often barriers green building purely financial include significant number non financial issues directly connected way green building initiatives integrated within management higher learning institutions hlis purpose paper explore reasons behind widespread barriers ways barriers could overcome strategic project management design methodology approach paper includes critical review existing literature barriers sustaining green building initiatives argument built need manage initiatives projects consequently establishes seamless connection hlis strategies projects hence strategic project management framework sustain green campus culture findings despite numerous barriers facing african hlis embracing green campus buildings gcbs part permanent business undertakings review strongly suggest change direction traditional approaches strategic project management green building initiatives transformed programmes portfolios dealing sub sets core business hlis practical implications strategic decision include green campus building initiatives gcbis part hlis core strategic business projects bring permanence gcb thinking resources allocated gcbis green campus thinking may become norm one metrics organization success social implications strategic project way creating conducive environment gcbis success become constant part way african hlis managed originality value contemporary management approaches like strategic project management embraced mean allowing resourced african hlis achieving significant reduction greenhouse gas emissions
social bonds center daily living essential determinant quality life people epilepsy numerous factors impede cognitive affective functions necessary smooth social interactions psychological psychiatric complications common epilepsy may hinder processing social information addition neuropsychological deficits slowed processing speed memory loss attentional difficulties may interfere enjoyable reciprocity social interactions consider societal psychological neuropsychological aspects social life particular emphasis socio cognitive functions temporal lobe epilepsy deficits emotion recognition theory mind two main aspects social cognition frequently observed individuals mesial temporal lobe epilepsy results behavioural studies targeting functions presented focus relevance patients daily life furthermore broach issue pitfalls current diagnostic tools potential directions future research giving broad overview individual interpersonal determinants social functioning epilepsy hope provide basis future research establish social cognition key component comprehensive assessment care epilepsy british epilepsy association published elsevier ltd rights reserved
march oral emergency contraceptives levonorgestrel lng ulipristal acetate upa released prescription status germany main research question analyse whether otc status oral emergency contraceptives influence patterns use information based searches public domain sources emergency contraception searches made scientific publications statistics surveys due additional active ingredient properties upa superior lng terms ovulation inhibiting effect since otc switch demand oral emergency contraceptives risen almost especially weekends sexual encounters thus contraceptive failures frequent however age distribution users changed result otc switch doctors still play important role advising emergency contraception removal prescription requirement pregnancies despite emergency contraception terminated half cases federal states higher rates use morning pill fewer terminations pregnancy performed result otc switch women girls use morning pill unprotected intercourse time unprotected intercourse taking oral emergency contraceptive decreases great advantage terms mechanism action upa used frequently lng half people aged years germany aware morning pill women pregnancy terminated use emergency contraception unprotected intercourse population still great need information education contraception emergency contraception
introduction casein one human milk sourced peptides differed significantly preterm full term mothers study designed demonstrate biological characteristics antibacterial activity mechanisms casein common pathogens neonatal infection methodology analysis biological characteristics done bioinformatics disk diffusion method flow cytometry used detect antimicrobial activity casein killing kinetics casein measured using microplate reader antimicrobial mechanism casein studied electron microscopy electrophoresis results bioinformatics analysis indicates casein derived casein showed significant sequence overlap antibacterial assays showed casein inhibited growth taphylococcus aureus ersinia enterocolitica ultrastructural analyses revealed antibacterial activity casein cytoplasmic structures disintegration bacterial cell envelope alterations combination dna conclusion conclude antimicrobial activity mechanism casein data demonstrate casein potential therapeutic value prevention treatment pathogens neonatal infection elsevier inc rights reserved
new approaches needed treatment patients cell acute lymphoblastic leukemia fail achieve remission chemotherapy analysis effects pan pim protein kinase inhibitors human cell lines demonstrated sensitive cell lines expressed higher pim protein kinase levels whereas cell lines notch mutations tended lower levels pim kinase insensitive inhibitors notch mutant cells selected resistance gamma secretase inhibitors developed elevated pim kinase levels increased sensitivity pim inhibitors gene profiling using publically available dataset demonstrated overexpression pim majority early cell precursor etp alls small subset non etp pim inhibitors blocked growth also stimulated erk stat phosphorylation demonstrating activation additional signaling pathways occurs pim inhibitor treatment block pathways ponatinib broadly active tyrosine kinase inhibitor tki used treat chronic myelogenous leukemia added pim inhibitor regimen combination ponatinib pim inhibitor resulted synergistic growth inhibition marked apoptotic cell death treatment mice engrafted human two agents significantly decreased tumor burden improved survival treated mice dual therapy potential developed novel approach treat high pim expression
although research established strong relationship presence psychiatric disorder victimization prisons gaps remain understanding study considers importance gender differences relationship estimates based survey inmates state federal correctional facilities show psychiatric disorders stronger relationship victimization among male inmates among female inmates yet size gender difference varies greatly depending specific disorder depressive disorders much stronger relationship victimization among men among women disorders psychosis show gender difference symptom specific analyses confirm nature difference victimization appears based part well symptoms overlap traditional gender roles male atypical symptoms sadness stronger relationship victimization among men whereas female atypical symptoms anger stronger relationship victimization among women gender neutral symptoms hallucinations delusions equivalent relationship genders analyses suggest gender differences explained exceptions verbal physical provocation findings interpreted light literature nature social control men women prisons well literature stigma
motivated reopening mechanics strongly collapsed airways study steady propagation air finger collapsed oil filled channel single compliant wall previous study using fully compliant elastic tubes pointed air finger found propagate high speed low pressure clinically accessible offers potential rapid reopening highly collapsed airways minimal tissue damage heap juel phys fluids vol mechanism underlying selection pointed finger however remained unexplained paper identify required selection mechanism conducting experimental study simpler geometry rigid rectangular hele shaw channel elastic top boundary constitutive behaviour elasto rigid channel nonlinear broadly similar elastic tube unlike tube channel cross section adopts self similar shapes undeformed state point first near wall contact ensuing simplification vessel geometry enables systematic investigation reopening dynamics terms increasing initial collapse find low levels initial collapse single centred symmetric finger propagates channel shape set tip curvature level collapse increases channel cross section develops central region near opposite wall contact finger shape evolves smoothly towards flat tipped finger whose geometry set strong depth gradient near channel walls show flat tipped mode reopening analogous pointed finger observed tubes propagation sustained vessel extreme cross sectional profile high collapse vessel compliance necessary stabilise simple scaling argument based dissipated power reveals reopening mode preferred higher propagation speeds becomes favourable displace elastic channel wall rather viscous fluid
young bisexual women experience worse mental sexual health outcomes comparison heterosexual lesbian peers disparities associated stigma devaluation bisexual identities current paper addresses community based focus group project participants discussed bisexual stigma regard bisexual erasure stereotypes specifically participants detailed experiences feeling pressured provide evidence bisexual identity modifying relationship sexual behavior conform expectations well feeling excluded queer community participants discussed experiences related decreased mental sexual health future research investigate relationship bisexual stigma pressure provide evidence bisexual identity negative mental sexual health outcomes
paper presents simulation results linear fully integrated two stage digitally programmable cmos power amplifier operating ghz power stage composed set amplifying cells enabled disabled independently digital control circuit seven operational modes univocal terms output compression point ocpdb saturated output power sat power gain ghz lowest power mode achieves dbm sat power gain consumes power ocpdb dbm whereas highest power mode reaches dbm sat power gain consumes ocpdb dbm
various system identification techniques exist literature handle non stationary measured time histories cases incomplete data address systems following fractional calculus modeling however many techniques address three aforementioned challenges simultaneously consistent manner paper novel multiple input single output miso system identification technique developed parameter identification nonlinear time variant oscillators fractional derivative terms subject incomplete non stationary data technique utilizes representation nonlinear restoring forces set parallel linear subsystems regard oscillator transformed equivalent miso system wavelet domain next recently developed norm minimization procedure based compressive sensing theory applied determining wavelet coefficients available incomplete non stationary input output excitation response data finally wavelet coefficients utilized determine appropriately defined time frequency dependent wavelet based frequency response functions related oscillator parameters several linear nonlinear time variant systems fractional derivative elements used numerical examples demonstrate reliability technique even cases noise corrupted incomplete data elsevier ltd rights reserved
meta analysis examined relationship moral identity moral behavior based studies broad range academic fields including business developmental psychology education marketing sociology sport sciences moral identity found significantly associated moral behavior random effects model effect sizes differ behavioral outcomes prosocial behavior avoidance antisocial behavior ethical behavior studies entirely based self reports yielded larger effect sizes contrast smallest effect found studies based implicit measures used priming techniques elicit moral identity moreover marginally significant effect culture indicated studies conducted collectivistic cultures yielded lower effect sizes studies individualistic cultures overall meta analysis provides support notion moral identity strengthens individuals readiness engage prosocial ethical behavior well abstain antisocial behavior however moral identity fares better predictor moral action psychological constructs
meckel cartilage mandible derived first branchial arch development depends upon contribution cranial neural crest cells prenatal development meckel cartilage along relationship developing mandible related structures studied histologically human embryos fetuses material obtained collection department anatomy laboratory procedures used prepare sections stained according standard light microscopy methods formation meckel cartilage related structures observed documented critical moments development meckel cartilage suggested sequential development meckel cartilage started early stage days appearance condensation mesenchymal cells within mandibular prominence stage days primary ossification center mandible appeared inferior margin meckel cartilage muscular attachments meckel cartilage embryos observed stage days subsequent movement developing mandible week seemed diminish role meckel cartilage supportive core simultaneously process regression within cartilage induced embryonic period bilateral meckel cartilages closest contact posterior surface superior margins preceding formation symphyseal cartilage site event sequence development meckel cartilage finally discussed
flexible thermoelectric materials prepared melt mixing technique easily scaled industrial level hybrid filler systems carbon nanotubes cnts copper oxide cuo environmental friendly materials contain abundant earth elements melt mixed thermoplastic matrix namely polypropylene cnt addition electrical network could built inside insulating effective charge transport effect cuo addition determined corresponding cnt concentration high cnt concentration largely percolation threshold phi change properties small contrast cnt concentration close phi addition cuo could simultaneously increase electrical conductivity seebeck coefficient cuo cnts loose percolated network formed seebeck coefficient increased electrical conductivity leading power factor composite cnts
evidence genetic overlap cognitive abilities schizophrenia scz genome wide association studies gwas demonstrate scz general cognitive abilities strong polygenic component many single nucleotide polymorphisms snps small effect investigated shared genetic architecture scz educational attainment regarded proxy phenotype cognitive abilities may also reflect traits applied conditional false discovery rate condfdr method gwas scz college completion college years education eduyears variants associated college eduyears showed enrichment association scz demonstrating polygenic overlap confirmed increased replication rate scz applying condfdr threshold identified genomic loci associated scz conditioning college loci associated scz conditioning eduyears ten loci overlapped using conjunctional fdr identified loci shared scz college loci shared scz eduyears majority loci effects opposite directions results provide evidence polygenic overlap scz educational attainment identify novel pleiotropic loci studies reported genetic overlap scz cognition scz educational attainment negative correlation importantly methods enable identification directional effects highlight complex relationship scz educational attainment support polygenic mechanisms underlying cognitive dysfunction creativity scz
atlas experiment used many years large database infrastructure based oracle store several different types non event data time dependent detector configuration conditions data calibrations alignments configurations grid sites catalogues data management tools job records distributed workload management tools run event metadata rapid development nosql databases structured storage services last five years allowed extended complementary usage traditional relational databases new structured storage tools order improve performance existing applications extend functionalities using possibilities offered modern storage systems trend towards using best tool kind data separating example intrinsically relational metadata payload storage records frequently updated benefit transactions archived information access components orchestrated specialised services run front end machines shield user complexity data storage infrastructure paper describes technology evolution atlas database infrastructure presents examples large database applications benefit
quantitative qualitative increase production obtained fields development cpus real time systems based case industrial sector automation process relieved partly wholly human activities needed manufacturing process mainly due time sharing embedded real time systems pseudo parallel execution tasks implementation single central processing unit present article presents validation nhse hardware scheduler engine scheduler implemented hardware using fpga xilinx virtex vivado development platform vivado simulator context main contribution relates custom interrupt management scheduling policy implemented hardware nhse level order provide predictable execution asynchronous interrupts reducing jitter handling asynchronous interrupts completely eliminating uncertainties scheduling limit set tasks significant improvement overall system predictability obtained
raindrop impact important process soil erosion pressure shear stress raindrop impact causes significant detachment soil material making material available transport sheet flow thanks accurate navier stokes equations solver gerris simulate impact single raindrop diameter terminal velocity water layers different thickness order study pressures shear stresses involved raindrop erosion complex numerical simulations help understanding precisely dynamics raindrop impact quantifying particular pressure shear stress fields detailed analysis fields performed self similar structures identified pressure shear stress soil surface evolution self similar structures investigated aspect ratio varies find pressure shear stress specific dependence ratio drop diameter water layer thickness scaling laws recently proposed fluid mechanics also applicable raindrops paving road obtain effective models soil erosion raindrops particular obtain scaling law formula dependence maximum shear stress soil water depth quantity crucial quantifying erosion materials copyright john wiley sons ltd
primary hypothesis stated paper use social choice theory ambient intelligence systems improve significantly users satisfaction accessing shared resources research methodology based agent based social simulations employed support hypothesis evaluate benefits result sixfold contribution summarized follows firstly several considerable differences application case prominent social choice application political elections found described secondly given differences number metrics evaluate different voting systems scope proposed formalized thirdly given presented application metrics proposed performance number well known electoral systems compared fourthly result performance study novel voting algorithm capable obtaining best balance metrics reviewed introduced fifthly improve social welfare experiments voting methods combined cluster analysis techniques finally article complemented free open source tool votesim ensures reproducibility experimental results presented also allows interested reader adapt case study presented different environments elsevier inc rights reserved
urinary incontinence largely spread disfunction affects million people worldwide present technological solutions able restore continence minimally invasive effective way article authors report design fabrication testing novel artificial endourethral urinary sphincter able fully restore continence device inserted retracted minimally invasive fashion without hospital admission alter body scheme applied women men device core unidirectional polymeric valve magnetically activated system able modulate opening pressure bench tests vivo tests human cadaver demonstrated device able fully restore continence allow urination desired overall proposed system shows high potential technological solution able restore normal daily life patients affected urinary incontinence
many robust image steganography methods invented recent decades however technique also may used malicious users transmit dangerous information internet beyond control security agencies detect block potentially dangerous information transmission internet billions images affecting normal digital images becomes challenging problem existing steganalysis methods steganography attacking methods used analyzing large volume digital images short time paper propose effective steganography attacking method limited types steganography method proposed method process digital images remove potentially dangerous hidden information keeping digital image high visual quality inspired way printers scanners work method decouples human visual perception digital image numerical values causes numerical values image change dramatically hidden information largely damaged time visual image quality maintained experimental results demonstrated peak signal noise ratio images stego data destroyed copyright john wiley sons ltd
building blocks made renewable sources attract increasing attention design new polymer systems recently particular context cellulose nanocrystals cncs gained great interest academic research industry mainly account ability reinforce range polymer matrices afford nanocomposites attractive mechanical properties limited thermal stability conventionally produced cellulose nanocrystals cncs however far limited range polymers could used basis melt processed cnc nanocomposites herein show commercially accessible nanocrystal source particular grade microcrystalline cellulose mcc easily converted thermally stable cncs ultrasonication phosphoric acid scalable melt mixing process used produce nanocomposites cncs thermoplastic polyurethane tpu elastomer significant improvement room temperature storage modulus mpa neat polymer mpa cnc observed introduction cncs increased stiffness polymer matrix also improved shape memory properties nanocomposite wiley periodicals inc appl polym sci
high temperature superconducting hts power applications necessary improve understanding dielectric properties materials cryogenic environment necessary know breakdown strength materials systems function gap order scale higher voltages partial discharge onset voltage materials also important since primary aging mechanism cryogenic temperature thought another important design characteristic surface flashover voltage material liquid nitrogen function gap characteristics mind several generic materials investigated variety electrode gap configurations impulse breakdown voltage onset three types commercial polyetherimide filled unfilled measured room temperature modest increase onset voltage observed lower temperature breakdown voltages fiberglass reinforced plastic frp cylinders two wall thicknesses measured showed decrease strength larger gap breakdown voltages liquid nitrogen using sphere plane electrode geometry measured also flashover voltages along frp plate immersed liquid nitrogen performed sphere plane rod plane electrodes bar pressure found breakdown voltage increased slightly increasing gap lengths
background atrial fibrillation prevalence increases significantly age little known effect ablation quality life healthcare utilization elderly objective study quantify healthcare utilization quality life benefits catheter ablation patients years compared patients years years length stay index procedure similar age groups older group younger group one day hospitalization disease specific quality life instrument scores improved significantly similarly older younger patients year postablation compared baseline related hospitalizations emergency department visits similar lower older patients compared younger patients reported year postablation conclusion older patients undergoing catheter ablation paroxysmal healthcare utilization parameters lower significantly different younger patients quality life outcomes similarly improved findings support use catheter ablation treatment option older patients paroxysmal
many studies highlighted widespread use skin lightening creams containing mercury women pregnancy remove dark spots women especially pregnant lactating mothers using products risk mercury poisoning sometimes clinical symptoms particularly early exposure studies shown prenatal postnatal mercury exposure cause permanent neurological damage children furthermore mercury cause women infertility birth defects even though several studies examined reproductive developmental consequences gestational lactational mercury exposure fish consumption dental amalgam studies assessed possible effects long term use mercury containing skin lightening products women childbearing age pregnancy outcome children health commentary aims collate information popular use mercury containing skin lightening creams sheds light readers limitations available data impact prenatal postnatal period urgent need assess adverse health effects applying products pregnancy lactation child growth development birth cohort studies data studies available women advised use topical skin lightening creams pregnancy lactation elsevier gmbh rights reserved
background evidence related effects tobacco exposure pregnancy infant child health focused women smoking cessation less often addressed men smokirig continued fatherhood reduces chances female partners cessation negatively impact children health well men health dads gear dig innovative program designed specifically new fathers want reduce quit smoking includes three components smoking cessation fathering physical activity arching purpose study evaluate feasibility dig program provide estimates program efficacy purpose article describe rationale protocol evaluating dig program feasibility acceptability potential effectiveness methods using prospective non comparative design dig program implemented evaluated six communities program offered trained facilitators fathers currently smoke want quit aim framework guide evaluation open ended questions participant surveys semi structured interviews weekly telephone briefs facilitators provide data process evaluation estimates effectiveness include smoking behavior fathering physical activity measures baseline end program month follow conclusion dig program could support positive changes respect smoking cessation physical activity overall health men effects could also promote family health program might also provide effective model engaging men health behavior change authors published elsevier inc
merging separation flocking groups often observed natural complex systems paper employ cucker smale particle model model merging separation phenomena definiteness consider interaction two homogeneous cucker smale ensembles present several sufficient frameworks mono cluster flocking cluster flocking partial flocking terms coupling strength communication weight initial configurations
common belief wrinkles aging face reflect frequently experienced emotions hence resemble affective displays implies wrinkles folds elderly faces interfere perception emotions currently experienced elderly well inferences perceivers draw expressions whereas ample research impact aging emotion recognition almost research focused emotions expressed elderly perceived others present research addresses latter question young participants rated emotion expressions behavioral intentions old young faces displaying identical expressions findings suggest emotions shown older faces reduced signal clarity may consequently less impact inferences regarding behavioral intentions effects expected negative consequences rapport achieved everyday interactions involving elderly elsevier inc rights reserved
existing theories empathic response visual art works postulate primacy automatic embodied reaction images based mirror neuron mechanisms arguing inclusive concept empathy related response integrating four distinct bodies literature discuss contextual personal factors modulate empathic response depicted people present integrative model empathy related responses depicted people art works model assumes response empathy eliciting figural artworks engages dynamic interaction two mutually interlinked sets processes socio affective cognitive processing related person perception esthetic processing primarily concerned esthetic appreciation judgment attention non social aspects image model predicts specific pattern interaction empathy related esthetic processing determined several sets factors viewer individual characteristics context variables include various modes priming narratives images iii multidimensional features image aspects viewer response finally propose model implemented interaction functionally connected brain networks involved socio cognitive esthetic processing
paper two dimensional nonlinear evolution equations nlees investigation employing hirota method symbolic computation derive bilinear form bilinear backlund transformation two nlees based bilinear form obtain multi soliton solutions furthermore multi soliton solutions terms wronskian determinant first nlee constructed whose validity verified direct substitution bilinear equations
background despite efforts made public health organizations improve consumption fruits vegetables populations developed countries usually eat less minimum recommended social media blogs represent unique opportunity improving knowledge translation health care facilitate interactive communication public health professionals however studies yet evaluated effect blogs promote dietary behavior changes objective study aims conduct preliminary assessment undertaking full randomized controlled trial rct feasibility using evidence based healthy eating blog promoting consumption fruits vegetables among adult women methods total women aged years older mean years eating less five servings per day fruit vegetables mean servings recruited participants randomized healthy eating blog group included weekly blog post month period control group exposure healthy eating blog blog posts written registered dietitian focused improvement fruit vegetable consumption targeted four main determinants behavior identified best predictors fruit vegetable intake two systematic reviews knowledge attitude self efficacy motivation intervention considered feasible questionnaires completed attendance rate person appointments research coordinator participants accessed least blog posts attrition rate less blog access assessed collecting blog browsing history data participant results intervention posts published blog pre baseline postintervention months questionnaires completed mean participants participants attended person appointments women accessed mean posts published intervention participants dropped study healthy eating blog control groups difference servings fruits vegetables indicated moderate effects intervention cohen conclusions results suggest intervention using healthy eating blog meets preestablished feasibility criteria larger scale rct using methodology conducted assess impact healthy eating blog dietary habits women
background care workers often exposed sexual harassment patients research shows exposure may detrimental effects mental health care workers inappropriate sexual behaviour patients particular challenge formal informal care workers alike scarceness studies investigating experience handling sexual harassment patients objectives investigate experience handling sexual harassment patients care work design study follows explorative qualitative approach based group interviews care workers settings ten workplaces participated study including hospitals nursing homes community health centres rehabilitations care centres psychiatric residential facilities participants conducted group interviews care workers employees managers shop stewards safety representatives majority interviewees trained nurses results interviews revealed sexual harassment complex multifaceted phenomenon care workers often separated intentional unintentional behaviours initiated cognitively impaired patients thus often refrain using term harassment implies actions intentional however interviews revealed practice separation difficult sexual harassment often creates range dilemmas daily work time sexual harassment taboo managers shop stewards safety representatives study often aware frequency impact episodes care workers workplaces participating study rarely guidelines policies managing preventing sexual harassment inappropriate sexual behaviours often responded episodes hoc case case manner conclusion term sexual harassment might appropriate context care work many patients display inappropriate behaviours cognitively impaired interviews revealed universally accepted term might prudent avoid term harassment refer sexual behaviours considering demographic development rising number elderly increase various forms dementia management inappropriate sexual behaviour patients even pressing future time address prevention sexual harassment management patients sexuality explicit part professional organisational culture care work elsevier ltd rights reserved
session initiation protocol sip signaling protocol widely applied world multimedia communication numerous sip authenticated key agreement schemes proposed purpose ensuring security communication farash recently put forward enhancement employing smart cards counted zhang scheme study observe enhanced scheme presented farash also security pitfalls disclosure user identity lack pre authentication smart card vulnerability key compromise masquerading attack results line guessing attack propose anonymous modified scheme elliptic curve cryptography eliminate security leakages scheme proposed farash demonstrate scheme immune different kinds attacks including attacks involved farash scheme mention burrows abadi needham logic completeness proposed scheme also compare performance scheme predecessor schemes comparative results shows perfectly satisfies needs sip
transition time states plays important role designing quantum devices sensitive environmental influences decoherence phenomenon responsible possible destructions entanglement fundamental requirement implement quantum information processing systems time states minimized decoherence effects reduced thus advantageous designer develop expressions time performance measures quantum speed limit qsl problem studied theoretical point view providing general results considering implementation quantum control systems decoherence phenomenon unavoidable important apply general results particular cases developing expressions performance measures assist control engineering designers minimum time performance measure defined quantum control problems time independent time dependent hamiltonians applied practical examples providing hints may useful researchers pursuing optimization strategies quantum control systems
paper generalized variable coefficient boiti leon pempinlli blp system studied via modified clarkson kruskal direct reduction method connected homogeneous balance method describe water waves fluid physics direct similarity reduction nonlinear ordinary differential system obtained solving reduced ordinary differential system new analytical solutions including solitary periodic types terms jacobi elliptic functions given variable coefficient blp system elsevier ltd rights reserved
grid enabled vehicles gevs plug electric vehicles present environmental energy sustainability advantages compared conventional vehicles gev runs solely power generated battery group supplies power electric motor battery group charged external electric sources nowadays interaction gev power grid unidirectional charging process however gev operated directionally modifying power unit operating conditions gev operate uninterruptible power supply ups satisfy portion total energy demand consumption center independent utility grid known vehicle home paper power unit developed gevs laboratory conduct simulation experimental studies test performance gevs ups unit mode time need activation deactivation power unit islanding protection unit examined energy interrupted
advancements information communication technologies icts introduced new computing paradigms cloud computing pervasive ubiquitous computing ambient intelligence aware computing techniques processing storing communicating sharing disseminating information radically changed novel computing paradigms bring enormous benefits availability universal access data reduction power storage hardware software costs availability elastic storage computation services advantages appealing side effect tremendous risk exposure confidential sensitive information privacy breaches wpes yearly forum year edition aiming discussing open privacy challenges emerging directions original novel approaches guaranteeing privacy today global interconnected society
deployment hydrogen technologies energy mix use hydrogen fuel cell vehicles fcv expected significantly reduce european greenhouse emissions carry social cost benefit analysis estimate period socio economic conversion period replacement gasoline internal combustion engine vehicles icev fcv becomes socio economically profitable study considered hydrogen production mix five technologies natural gas reforming processes without carbon capture storage electrolysis biogas processes site production estimate two external costs abatement cost fcv use non renewable resources manufacture fuel cells measuring platinum depletion forecast carbon market could finance approximately deployment cost hydrogen based transport early economic conversion could targeted fcv almost ten years could saved considering externalities hydrogen energy publications llc published elsevier ltd rights reserved
wnt beta catenin signaling plays key role embryonic development stem cell biology neurogenesis however mechanisms wnt signal transmission notably receptors regulated remain incompletely understood describe parkinson disease associated receptor gpr functions maturation terminal bulky beta propellers wnt receptor lrp gpr required wnt beta catenin signaling protects lrp associated degradation via chip carboxyl terminus hsc interacting protein atpase vcp gpr highly expressed neural progenitor cells npcs required wnt dependent neurogenesis conclude gpr crucial cellular protein quality control wnt signaling
first review history prior failure tacoma narrows suspension bridge consider popular accounts popular physics literature scientific scholarly basis accounts point failings later give quick introduction three different models one single particle one continuum model two systems two degrees freedom
manganese required various human physiological processes excessive exposure causes manganism progressive neurodegenerative disorder similar idiopathic parkinson disease ipd however detailed mechanism induced neurotoxicity yet fully understood micrornas mirnas play important roles gene expression regulation mirna expression profile provides additional biological prognostic information diseases study rna sequencing performed profile mirnas syy cells following mncl treatment expressions mirnas altered following excessive treatment furthermore mir identified target utr atpa park directly inhibition mir efficiently restored induced cytotoxicity thus first time revealed mirna effects ions neuron cells highlighted involvement mirna regulation neurodegeneration caused exposure provided potential application mirnas future therapeutic intervention elsevier inc rights reserved
assess seroprevalence anti toxoplasma gondii antibodies igg igm egyptian rheumatoid arthritis patients versus non group compare anti toxoplasma antibodies seroprevalence among patients receiving traditional treatment patients treated biologic drug patients healthy controls enrolled study patients categorized two groups one group included patients receiving disease modifying anti rheumatic drugs dmards group included patients receiving biologic agent infliximab tnf alpha antagonist serum samples investigated persons examined anti toxoplasma antibodies activity markers including rheumatoid factor anti cyclic citrullinated protein antibodies reactive protein esr addition disease activity score das patients also evaluated explore association toxoplasma seropositivity anti toxoplasma igg antibodies detected among patients versus controls anti toxoplasma igg titre higher among group median range among controls median range difference detected among patients either traditional biologic treatment regarding anti toxoplasma igg antibodies positive anti toxoplasma igm detected positive correlation detected anti toxoplasma igg titre disease activity markers higher seroprevalence anti toxoplasma igg antibodies among patients compared controls reflects association latent toxoplasma infection findings support previous studies necessitate future large scale studies elucidate exact role toxoplasma whether trigger autoimmunity effect immunosuppression
younger siblings children autism spectrum disorder asd high risk siblings exhibit lower levels initiating joint attention ija sharing object experience social partner gaze gesture low risk siblings children without asd however high risk siblings also exhibit substantial variability domain neurotransmitter dopamine linked brain areas associated reward motivation attention common dopaminergic variants associated attention difficulties examined whether common dopaminergic variants drd drd explain variability ija high risk low risk siblings ija assessed first year semi structured interaction examiner drd drd genotypes coded according associated dopaminergic functioning create gene score higher scores indicating genotypes associated less efficient dopaminergic functioning higher dopamine gene scores indicative less efficient dopaminergic functioning associated lower levels ija first year high risk siblings opposite pattern emerged low risk siblings findings suggest differential susceptibilityija differentially associated dopaminergic functioning depending familial asd risk understanding genes linked asd relevant behaviors high risk siblings aid early identification children greatest risk difficulties behavioral domains facilitating targeted prevention intervention autism res international society autism research wiley periodicals inc
paper introduces novel domain specific compiler translates visual computing programs written dynamic languages highly efficient code define dynamic languages python matlab feature dynamic typing flexible array operations language features useful rapid prototyping however dynamic computation model introduces significant overheads program execution time introduce compiler framework accelerating visual computing programs graphics vision programs written general purpose dynamic languages compiler allows substantial performance gains frequently orders magnitude general compilers dynamic languages specializing compiler visual computation specifically compiler takes advantage three key properties visual computing programs permit optimizations many array data structures small constant bounded size many operations visual data supported hardware embarrassingly parallel humans sensitive small numerical errors visual outputs due changing floating point precisions compiler integrates program transformations described previously improves existing transformations handle visual programs perform complicated array computations particular show dependent type analysis used infer sizes guide optimizations many small sized array operations arise visual programs programmers experts visual computation use compiler produce efficient python programs write manually parallelized fewer lines application logic
gefitinib erlotinib afatinib three widely used epidermal growth factor receptor tyrosine kinase inhibitors egfr tkis treating advanced non small cell lung cancer nsclc proven efficacy undertook systematic review meta analysis synthesize existing studies direct comparisons egfr tkis nsclc terms efficacy safety eight randomized trials cohort studies total patients included analysis gefitinib erlotinib demonstrated comparable effects progression free survival hazard ratio confidence interval overall survival overall response rate risk ratio disease control rate vary considerably egfr mutation status ethnicity line treatment baseline brain metastasis status gefitinib associated grade liver dysfunction tended cause lower rates dose reduction treatment discontinuation total grade adverse events number specific adverse events rash diarrhea solid evidence found afatinib greater efficacy gefitinib erlotinib first line treatment egfr mutant nsclc however afatinib effective erlotinib second line treatment patients advanced squamous cell carcinoma grade adverse events rate afatinib comparable erlotinib higher gefitinib new drug best treating non small cell lung cancer authors compared three chemotherapy drugs two around decade one second generation agent approved use three well studied direct comparisons undertaken authors performed systematic review meta analysis existing literature found three drugs similar effectiveness first line chemotherapy nsclc gefitinib seemed spur fewer adverse events however afatinib newer drug worked better others second line treatment advanced squamous cell carcinoma
compared traditional radio atmospheric detection radar detection gnss occultation technique provides powerful tool atmospheric detection gnss occultation technique characteristics without calibration weather high precision high vertical resolution global uniform coverage gnss occultation technique based atmosphere gps leo radio occultation gps satellite radio signal obscured earth atmosphere gps satellite radio signal cutting earth atmosphere ionosphere sectional radio signal refracted reach leo satellites received gps signal contains information earth atmosphere ionosphere get atmospheric ionosphere electron density profile total electron content ionosphere atmospheric bending angle profiles index refraction temperature barometric pressure relevant atmospheric inversion model paper introduces gps radio occultation atmospheric detection technology based mountain based experimental verification test located wuling mountain peak yanshan mountains located chengde hebei province degrees degrees similar made detailed presentation signal capture signal track data quality different prediction algorithm spaceborne occultation test used mountain based occultation prediction based fixed position getting forecast results week occultation event mountain conditions factors occultation signal capture different different azimuths made comparison different azimuths making analysis signal noise ratio snr consistency carrier phase pseudorange reason signal loss lock order verify accuracy gps radio atmospheric occultation article compares refractive index profile obtained inversion meteorological data test results better
paper proposes novel adaptive fractional order pid sliding mode controller afopidsmc using bat algorithm control caterpillar robot manipulator fractional order pid fopid control applied improve trajectory tracking robustness sliding mode controller smc one control methods provides high robustness low tracking error using hybridization new combined control law proposed chattering reduction means fopid controller high trajectory tracking using smc adaptive controller design motivated smc applied updating fopid parameters metaheuristic approach bat search algorithm based echolocation behavior bats applied optimal design caterpillar robot order tune parameter afopidsmc controllers afopidsmc study effectiveness bat algorithm performance compared five controllers pid fopid smc afopidsmc pso afopidsmc stability afopidsmc controller proved lyapunov theory numerical simulation results completely indicate advantage afopidsmc trajectory tracking chattering reduction elsevier ltd rights reserved
influence particle shape mechanical behavior sand woven geotextile interfaces wide domain soil density normal stress studied uniformly graded angular fine sand blend well rounded glass beads identical particle size distributions selected granular material experiments revealed impact particle shape peak residual friction angles well maximum dilation angle interfaces granular media woven geotextile observed residual friction angles interfaces angular sand glass beads woven geotextile similar residual friction angles angular sand glass beads soil soil direct shear test understood peak friction angle maximum dilation angle angular sand woven geotextile slightly lower corresponding values angular sand soil soil direct shear test peak friction angle maximum dilation angle angular sand woven geotextile interface decrease increase normal stress experiments showed factors insensitive normal stress glass beads woven geotextile interfaces least range studied herein interfaces woven geotextile contact surface exhibit abrupt loss shear strength post peak regime behavior finally unified stress dilation law angular sand woven geotextile glass beads woven geotextile angular sand roughened steel interfaces obtained elsevier ltd rights reserved
objective compare curative effects two unilateral puncturation percutaneous vertebroplasty pvp pain caused multiple level osteoporotic vertebral body compression fractures ovcf senile patients patients methods june november eighty nine cases suffering fresh multiple level ovcf randomly divided experimental group control group patients underwent pvp guided arm fluoroscopy prone position monitored recorded visual analgesic scale vas pre operation days post operation operation time exposure duration bone cement injection amount extraosseous cement leakages results pvp procedures successful groups without serious complications vas scores two groups days post operation significantly lower vas scores pre operation operation time exposure duration observational group significantly lower control group conclusions curative effects two unilateral puncturation pvps satisfactory however puncturation method lower operation time lower ray exposure dose concluded puncturation method suitable method considered clinical application
background early diagnosis treatment prediabetes type diabetes mellitus tdm prevent future health problems yet many individuals conditions undiagnosed could due part primary care physicians pcp screening practices little known objectives study identify factors influence pcps decisions screen patients tdm characterize interpretation communication screening test results patients methods conducted semi structured chart stimulated recall interviews university michigan health system umhs primary care physicians pcps asked recent decisions screen screen purposively sampled non diabetic patients met american diabetes association criteria screening tdm interviews audio recorded transcribed analyzed using qualitative directed content analysis data patient demographic characteristics comorbidities abstracted electronic health record results common reasons pcps gave screening patients tdm knowledge previously normal screening test visit reasons health maintenance examination common reasons pcps gave screening patients tdm knowledge previously abnormal screening test patients weight age pcps correctly interpreted screening test results communicated test results patients among patients found prediabetes pcps usually recommended weight loss increased physical activity never recommended participation diabetes prevention program use metformin conclusions previous screening test results visit types patients weight age influenced pcps decisions screen tdm patients screened test results generally correctly interpreted consistently communicated recommendations patients prediabetes could better reflect evidence based strategies prevent tdm
model human tissue report considers rate free radical generation dilute solution water beta emitting radionuclide uniformly dispersed decay dissipates discrete quantity energy creating large number free radicals short time within small volume determined beta particle range representing instantaneous dissipated power train randomly spaced pulses time averaged dissipated power rate free radical generation derived analogous result theory electrical circuits known shot noise theorem reference dose rays ref producing identical rate free radical generation level oxidative stress shown increase square root absorbed dose far larger finding may important consequences public health cases level shot noise exceeds noise floor corresponding equilibrium biological processes estimate noise floor made using example potassium beta emitting radioisotope universally present living tissue elsevier ltd rights reserved
ikumen buzzword describes fathers actively involved childrearing article focuses process term ikumen meaning diffused investigates soon fathers potential ikumen view ikumen discourse endeavor grasp transformation father roles wider family contemporary japan public individual engagement term ikumen article combine macro micro approaches analyze ikumen discourse circulating japanese society study way subjects discourse soon fathers view ikumen discourse interact utilizing analysis newspaper articles inquire process concept ikumen became popular japan images affiliated interviews investigate soon fathers potential ikumen perceive term results show way ikumen discourse emerged japan opposition term kazoku sabisu since describes activities fathers engage satisfaction families fulfillment social expectations however term popular media young families interviewed see ikumen skeptically resist popular discourse adapt construction paternal identities differentiation strong versus weak ikumen image
information animals die important understand population regulation migratory animals mortality might occur stationary periods breeding wintering also migration seasons however relative importance population limiting factors different periods year remains poorly understood previous studies mainly relied indirect evidence provide direct evidence migrants die identifying cases confirmed probable deaths three species long distance migratory raptors tracked satellite telemetry show mortality rate six times higher migration seasons stationary periods however total mortality surprisingly similar periods explained fact risky migration periods shorter safer stationary periods nevertheless half annual mortality occurred migration also found spatiotemporal patterns mortality spring mortality occurred mainly africa association crossing sahara desert mortality autumn took place europe results strongly suggest events migration seasons important impact population dynamics long distance migrants speculate mortality spring migration may account short term annual variation survival population sizes mortality autumn migration may important long term population regulation density dependent effects
paper presents robust distributed algorithm solve general linear programs algorithm design builds characterization solutions linear program saddle points modified lagrangian function show resulting continuous time saddle point algorithm provably correct general distributed global parameter associated nonsmooth exact penalty function employed encode inequality constraints linear program motivates design discontinuous saddle point dynamics enjoying convergence guarantees fully distributed scalable dimension solution vector also characterize robustness disturbances link failures proposed dynamics specifically show integral input state stable input state stable latter fact consequence general result also establish states algorithmic solution linear programming input state stable uncertainty problem data affects dynamics disturbance results allow establish resilience proposed distributed dynamics disturbances finite variation recurrently disconnected communication among agents simulations optimal control application illustrate results
purpose elastic therapeutic tape widely used rehabilitation treatment sports injuries tapes different elastic properties serve different treatment purposes inappropriate tension reducing tape effectiveness many tapes available market studies tape properties limited aim study examine material properties elastic therapeutic tape subjects methods brands elastic therapeutic tape included kinesiotex atex mueller thaitape material testing system insight electromechanical testing systems used apply tensile force elastic therapeutic tape ten specimens brand tested stress load young modulus maximum point collected one way analysis variance post hoc testing used analyze tape parameters results maximum elongation young modulus percentages significantly different brands differences maximum load maximum stress conclusion mechanical properties different commercial elastic therapeutic tapes physiotherapists clinicians aware mechanical tape properties correctly apply kinesio tape
cortical networks underpinning attentional control mentalizing converge right temporoparietal junction rtpj debated whether rtpj fractionated neighboring separate functional modules underpinning attentional control mentalizing whether one overarching cognitive mechanism explains rtpj role domains addressing question combined attentional control mentalizing factorial design within one task added social context condition another individual mental states became apparently task relevant spatial cueing paradigm allowed assessing cue validity context dependent functional activity effective connectivity rtpj within corresponding cortical networks found two discriminable rtpj subregions anterior posterior one yet observe sharp functional dissociation two regions responded attention cueing social context manipulation results suggest rtpj part ventral attention tom network function defined context dependent coupling respective network argue rtpj functional unit underpins overarching cognitive mechanism attentional control mentalizing discuss present results help specify mechanism
present new concept designing biomimetic analogs enzymatic proteins analogs based synthetic protein like copolymers alpha chymotrypsin used prototype artificial catalyst experimental study shows course free radical copolymerization hydrophobic hydrophilic monomers target globular nanostructures core shell morphology appear selective solvent using mesoscale computer simulation show protein like globules large number catalytic centers located hydrophobic core hydrophilic shell interface elsevier rights reserved
background organisms typically face infection diverse pathogens hosts thought developed specific responses type pathogen encounter advent transcriptomics makes possible test hypothesis compare host gene expression responses multiple pathogens genome wide scale performed meta analysis multiple published new transcriptomes using newly developed bioinformatics approach filters genes based expression profile across datasets thereby identified common unique molecular responses model host species honey bee apis mellifera major pathogens parasites microsporidia nosema apis nosema ceranae rna viruses ectoparasitic mite varroa destructor transmits viruses results identified common suite genes conserved molecular pathways respond investigated pathogens result suggests commonality response mechanisms diverse pathogens found genes differentially expressed infection exhibit higher evolutionary rate non differentially expressed genes using new bioinformatics approach unveiled additional pathogen specific responses honey bees found apoptosis appeared important response following microsporidian infection genes immune signalling pathways toll imd differentially expressed varroa virus infection finally applied bioinformatics approach generated gene expression network identify highly connected hub genes may represent important mediators regulators anti pathogen responses conclusions meta analysis generated comprehensive overview host metabolic biological processes mediate interactions insects pathogens identified key host genes pathways respond phylogenetically diverse pathogens representing important source future functional studies well offering new routes identify generate pathogen resilient honey bee stocks statistical bioinformatics approaches developed study broadly applicable synthesize information across transcriptomic datasets approaches likely utility addressing variety biological questions
aging skin undergoes progressive structural functional degeneration leaves prone wide variety bothersome even serious conditions diseases skin conditions diseases may affect ages cradle grave disproportionate burden clearly fall elderly may significantly impact quality life qol reduced ability skin regenerate elderly increased risk skin breakdowns even simplest insults therefore vital skin care late adulthood seen priority among clinicians caregivers scientific literature diagnosing assessing age related skin conditions diseases vast however comes preventive care treatment scientific data available less profound recommendations often based personal experience opinions best consensus documents rather scientific data retrieved controlled clinical trials addition absence scientific data imprecise terminology describe topical products well lack understanding essence vehicle contributes vague often unhelpfully product recommendations paper aims elucidate basic principles skincare choice skincare products regulatory status paper discusses adherence topical therapies percutaneous absorption elderly skin surface skin care lastly also discusses skin care principles selected age related skin conditions diseases
national estimates health economic burdens exposure ambient fine particulate matter india reveal substantial impacts information often lacking local level justify drive mitigation interventions assess health economic gains resulting attainment guidelines concentrations including interim target interim target air quality guideline aqg nagpur district inform policy decision making mitigation conducted detailed assessment concentrations areas covering urban peri urban rural environments february june used combination hazard survival analyses based life table method calculate attributed annual number premature deaths disability adjusted life years dalys five health outcomes linked exposure acute lower respiratory infection children years used gbd data deaths dalys diseases calculated averted deaths dalys economic loss resulting planned reductions average concentration current level aqg years respectively economic cost premature mortality estimated product attributed deaths value statistical life india morbidity assumed mortality cost annual average concentration nagpur district results confidence interval thousand premature deaths thousand dalys economic loss usd billion year estimated interventions achieve aqg would avert respectively attributed health economic loss years translating impressively large health economic gain achieve recommend exposure integrated source reduction approach elsevier ltd rights reserved
article presents methods translate behavioral level analog description field programmable analog array fpaa implementation methods consist several steps referred function decomposition macrocell synthesis placement routing postplacement simulation focus article first three steps function decomposition step deals decomposing high order system function set lower order functions present efficient procedure searching optimal solution procedure based first formally demonstrating equivalence two previously used optimization criteria objective macrocell synthesis step generate hardware realization modified signal flow graph introduced represent fpaa circuits graph transformations used identify realizations comply fpaa hardware constraints modified signal flow graph also allows scaling capacitor values due limited set allowable values fpaa placement routing step efficient method estimate circuit performance degradation due parasitic effects given using performance degradation cost function algorithm finding optimal fpaa placement routing configuration given efficacy methods developed demonstrated direct measurements set filters
use poly ethylenedioxythiophene poly styrenesulfonate pedot pss electrodes electrical circuits presents number challenges yet overcome foremost amongst relatively low conductivity low coatability hydrophobic substrates decreased conductivity large strains mind study suggests simple way simultaneously address issues addition small amount nonionic surfactant triton commercial pedot pss solutions surfactant shown considerably reduce surface tension pedot pss solution thus permitting conformal coatings pedot pss thin film diverse range hydrophobic substrates furthermore surfactant induces formation pedot nanofibrils coating led high conductivity values mechanical stability large strains epsilon taking advantage superior characteristics pedot pss thin films highly flexible polymer solar cell fabricated power conversion efficiency solar cell zero strain preserved large strains epsilon
comorbidities associated psoriatic arthritis psa include cardiovascular diseases diabetes mellitus obesity study evaluated association psa common gastrointestinal diseases retrospective study performed israel largest health care provider database psa patients matched age sex randomly selected patients searched patients records presence peptic ulcer disease pud reflux esophagitis crohn disease ulcerative colitis irritable bowel syndrome ibs celiac disease test used compare continuous variables chi square test used categorical variables multivariate logistic regression models used assess association psa comorbidities psa associated crohn disease ulcerative colitis reflux esophagitis pud ibs controlling known risk factors association remained significant psa crohn disease ulcerative colitis reflux esophagitis pud significant association found psa celiac disease current study psa associated gastrointestinal morbidities including crohn disease ulcerative colitis pud ibs physicians treating patients psa aware associations
microscopy imaging single technology usually restricted single contrast mechanism multimodal imaging promising technique improve structural information could obtained device test dut due different contrast mechanisms laser scanning microscopy lsm confocal laser scanning microscopy clsm optical beam induced current microscopy obicm combination could improve detection structures integrated circuits ics helps reveal layout obic imaging sensitive changes differently doped areas semiconductor metal transitions clsm imaging mostly sensitive changes absorption reflection work present implementation obic imaging clsm show first results using industry standard atmel microcontrollers mcus feature size duts analyzing types microcontrollers helps improve field side channel attacks find hardware trojans possible spots laser fault attacks reverse engineering experimental results dut placed custom circuit board allows measure current imaging house built stage scanning microscope using near infrared nir laser diode light source dut thinned polished allowing backside imaging substrate demonstrate possibilities using optical setup evaluating obic lsm clsm images threshold laser source
objective determine frequency thyroid dysfunction patients menstrual disturbances patients methods multidisciplinary case series study six months conducted jan june lumhs jamshoro sindh pakistan ladies menstrual disturbances evaluated thyroid dysfunction screen serum tsh level data collected analyzed spss frequency percentages calculated results total fifty ladies menstrual disturbances recruited screened serum thyroid hormone levels means age whole population frequency thyroid dysfunction hypothyroidism predominant disorder common menstrual disturbances observed menorrhagia oligomenorrhea respectively conclusion thyroid dysfunction taken important etiological factor menstrual abnormalities
introduction enduro road motorcycling event fast exciting adventure sport increasing numbers participants competitions materials methods performed search pubmed medline cinahl embase databases using following keywords enduro injuries road motorcycle injuries enduro sport identified four studies described physiological characteristic enduro riders injury pattern sustained athletes results hands wrists forearms predominant areas overuse enduro riders extremities injured parts enduro however injuries mild moderate abbreviated injury scale grades conclusion paucity published data enduro injuries depth understanding physiological aspect enduro riders close monitoring injuries needed promote safety measures enduro reduce risk factors injury turn help make enduro safe alternative dangerous motorcycling sports
technology smart skin radar stealth belong active radar stealth active radar stealth important branch target radar signature control technology also known radar stealth technology smart skin radar stealth device mentioned united states patent detailed description device paper wants make quantitative analysis smart skin radar stealth device firstly basic working principle device described constraint equations electromagnetic field given secondly quantitative relationship phase shift incident frequency incident angle spatial relationship factors derived finally stealth performance influenced incident frequency incident angle spatial position discussed numerical simulation
determining residual stress casting processes important evaluating mechanical properties strength materials optimize manufacturing conditions study propose field data interface procedure fdm fem dimensional space analyzing casting process structural analysis casting process analyzed using fdm data temperature distribution converted format suitable fem analysis calculate thermal stress safety factor tightening force results coupled analysis fdm fem showed casting residual stress important factor predicting life time evaluating durability
recent work demonstrated black hole thermodynamics information loss restoration ads cft derived almost entirely behavior virasoro conformal blocks large central charge relatively little dependence precise details cft spectrum ope coefficients elaborate non perturbative behavior virasoro blocks classifying saddles contribute arbitrary values external internal operator dimensions semiclassical large central charge limit leading saddles determine naive semiclassical behavior virasoro blocks decay exponentially late times rate independent internal operator dimensions consequently semiclassical contribution finite number high energy states resolve well known version information loss problem ads however identify two infinite classes sub leading saddles one classes decay late times
article examines transformation rice farming commercial aquaculture implications gender roles relations women access control resources household food security livelihood primary data collected sample households located across villages northern southern bangladesh used study data analyzed using qualitative quantitative methods namely wealth ranking technique self assessment technique gini coefficient lorenz curve descriptive statistics commercial aquaculture increased farm income income inequality brought new sources employment changed gender roles relations altered women access control resources altered household food consumption patterns increased market dependence staple food commercial aquaculture decreased workload women also weakened access control agricultural products women became dependent husband income lesser control use farm mechanization reduces women farmer drudgery diversification rice monoculture toward rice based high value crops aquaculture improves welfare everyone society implies poor farmers including women provided better access improved technologies credit
natural photosynthesis effective route clean sustainable conversion high energy chemicals inspired natural process tandem photo electrochemical pec cell integrated enzyme cascade tpiec system designed transfers photogenerated electrons multienzyme cascade biocatalyzed reduction methanol hematite photoanode bismuth ferrite photocathode applied fabricate iron oxide based tandem pec cell visible light assisted regeneration nicotinamide cofactor nadh cell utilized water electron donor spontaneously regenerated nadh complete tpiec system superior three dehydrogenase cascade system employed cathodic part pec cell applied bias tpiec system achieved high methanol conversion output molg using readily available solar energy water
june supreme court ruled video games enjoy full free speech protections regulation violent game sales minors unconstitutional supreme court also referred psychological research violent video games unpersuasive noted research contains many methodological flaws recent reviews many scholarly journals come similar conclusions although much debate continues given past statements american psychological association linking video game media violence aggression supreme court ruling particularly critique science likely shocking disappointing psychologists one possible outcome psychological community may increase conclusiveness statements linking violent games harm form defensive reaction however article author argues psychological community would better served reflecting research considering whether scientific process failed permitting even encouraging statements video game violence exceeded data ignored conflicting data although likely debates issue continue move toward caution conservatism well increased dialogue scholars opposing sides debate necessary restore scientific credibility current article reviews involvement psychological science community brown entertainment merchants association case suggests might learn errors case future
consumption gluten containing diet causes disease significant minority people consume foods derived wheat rye barley possibly oat fact however several types diseases related consumption gluten containing cereals trigger compounds components gluten current view medical experts excluding people suffering celiac disease majority individuals feeling better wheat free gluten free diet could select food containing much healthier low level fermentable oligosaccharides often called fodmap satisfy specific health related demands certain consumer groups challenge front cereal breeding develop new healthier germplasms suitable produce products food industry report aims give overview aspects recent developments booming area summarizing date knowledge cereals related health disorders reporting status developing celiac safe cereals finally iii highlighting potential developing healthier spelt based cereal products progress ongoing spelt breeding program
aim study develop poly hydroxybutyrate hydroxyvalerate phbv bionanocomposites natural vermiculite vmt modified vermiculite vmto melt intercalation technique evaluate thermal behavior biodegradation food packaging interactions ray diffraction xrd xrd observed structure microcomposite systems natural clay possibly exfoliated structure systems vmto observed thermogravimetry differential scanning calorimetry results natural systems showed small increase thermal stability whereas organoclay systems lower thermal stability high biodegradability pure polymer natural bionanocomposites evidenced sturm test carbon dioxide production high weight loss material observed significant migration phbv bionanocomposites simulants circumstances bionanocomposites vmt presented better thermal stability high biodegradability possibly inert contact food wiley periodicals inc
emergence microsoft kinect sensor many developer communities research groups found countless uses already published wide variety papers utilize raw depth images specific goals new methods applications use device generally require appropriately large ensemble data sets accompanying ground truth testing purposes well accurate models account various systematic stochastic contributors kinect errors current error models however overlook intermediate infrared images directly contribute noisy depth estimates therefore propose high fidelity kinect depth image predictor simulator models physics transmitter receiver system unique dot pattern disparity depth processing technology random intensity speckle noise detectors model accounts important characteristics kinect stereo triangulation system including depth shadowing dot splitting spreading occlusions correlation based disparity estimation windows measured reference images subpixel refinement results show simulator accurately produces axial depth error imaged flat surfaces various tilt angles well bias standard lateral error object horizontal vertical edge
asme technical paper solute ion coulomb force monopole motor solute ion linear alignment propulsion author describes motor based arrangement solute ion electric field monopoles process called capacitive deionization sodium chlorine ions salt water captured confined electrically conductive material form electric field monopoles least four like charged monopoles negative positive arranged disc least one stationary monopole charge placed adjacent disc positioned repulsive electric field formed stationary monopole least one monopoles positioned disc disc forced rotate shaft center disc paper analyzes behavior dielectric materials forming part monopoles show net torque motor greater zero also illustrates novel effect polarization dielectric material positioned two like charged monopoles occurs configuration monopole motor deficiency conventional closed path analysis work performed movement electric charges emit electrostatic fields failing consider effects dielectric materials shielding electrostatic fields monopole motor connected electrical generator provide continuous board electrical power electrical loads local deep space applications including power electrode assemblies designed linear alignment like charged solute ions means propulsion particle acceleration described paper details monopole motor propulsion available solute ion coulomb force acceleration electric field monopole passive voltage source author ref published elsevier selection peer review responsibility integrity research institute
introduction knee injuries frequent children studies reporting traumatic knee injuries evidence risk factors knee injuries children sparse purpose study report extent traumatic overuse knee injuries children evaluate intrinsic extrinsic factors risk injuries methods weekly musculoskeletal pain sport participation sports type reported school children knee injuries classified traumatic overuse multinomial logistic regression used analyses results study period traumatic overuse knee injuries diagnosed period prevalence traumatic overuse knee injuries sport participations respectively participation tumbling gymnastics risk factor traumatic knee injuries overuse knee injuries intrinsic risk factors sex girls previous knee injury whereas participation soccer handball basket rhythmic tumbling gymnastics additional risk factors injury types sport participation two times per week increased odds conclusions overuse knee injuries frequent injury type traumatic knee injuries participation tumbling gymnastics risk factor risk factors overuse knee injuries girl previous knee injury participation soccer handball basket rhythmic tumbling gymnastics risk factors types injury participation sports two times per week although growth related overuse knee injuries self limiting condition major part children affected injuries unknown short long term consequences
mobile app market continues grow tremendous rate market provides convenient efficient distribution mechanism updating apps app developers continuously leverage mechanism update apps rapid pace mechanism ideal publishing emergency updates updates published soon previous update paper study emergency updates google play store examining updates mobile apps google play store identify emergency updates studying characteristics emergency updates find emergency updates often long lifetime rarely followed another emergency update updates preceding emergency updates often receive higher ratio negative reviews emergency updates however release notes emergency updates rarely indicate rationale updates hence manually investigate binary changes several emergency updates find eight patterns emergency updates categorize eight patterns along two categories updates due deployment issues updates due source code changes find identified patterns emergency updates often associated simple mistakes using wrong resource folder images sounds app manually examine pattern document causes impact user experience app developers carefully avoid patterns order improve user experience
purpose reviewin urged countries provide art people living hiv irrespective cell count new recommendation supports joint united nations programme hiv aids elimination targets however meet aims urgent scale viral load testing critical multiple interventions healthcare system required support scale viral load testing reviewed recent findingsit estimated million individuals accessing antiretroviral therapy consequently cause significant demand viral load monitoring however current rate implementation demand meet required target change trajectory multiple stakeholders must involved communities key populations need increased treatment literacy create demand greater numbers healthcare workers require training addition laboratories point care testing sites need expanded adequate monitoring evaluation tools need put place identify gaps system institute prompt corrective actions direct resources needed summarysufficient scale viral load may well possible innovations mhealth used support healthcare workers patients regard scale effective use viral load monitoring new laboratory technologies implemented centralized level point care manage higher volumes improve coverage careful coordination implementing partners funders
studies reported analyze factorial structure facebook addiction italian questionnaire faiq variant item young internet addiction test iat study tested faiq psychometric properties using exploratory factor analysis efa study performed confirmatory factor analysis cfa verify faiq factorial structure identified efa results cfa confirm presence four factor model accounting percent total variance plus general higher order factor best fits data relationships faiq factor scores personality facebook usage explored
paper presents four stage operational amplifier opa high gain large bandwidth combining capacitor feedforward compensation reversed nested indirect compensation proposed opa simulated tsmc cmos process achieving gain mhz gain bandwidth product slew rate power dissipation supply voltage
purpose study patterns project collaboration found one government supported programme construction innovation preferred types interaction identified using data two questionnaire surveys one experienced construction sector respondents one aimed construction researchers sixteen development projects within swedish bygginnovationen programme investigated relying documents survey project managers important types interaction according construction respondents informal contacts joint research projects staff mobility university respondents informal contacts also seen important type interaction followed msc thesis work firms industrial phd candidates grant applicants manufacturing depended university laboratories less sensitive firm university distance laboratory use also frequent projects relying field materials engineering conclusion consensus types collaboration valuable broadness participation programme ranging many industries origin ideas ultimate applications reaches beyond narrow interpretations construction industry policy makers recognize innovation importance university laboratory facilities field testing rather seeing researchers sources ideas
due high computing demand whole trip train dynamics simulations iterative nature optimizations whole trip train dynamics optimizations using sequential computing schemes practically impossible paper reports advancements whole trip train dynamics optimizations enabled using parallel computing technique parallel computing scheme whole trip train dynamics optimizations presented discussed two case studies using parallel multiobjective particle swarm optimization pmopso parallel multiobjective genetic algorithm pmoga respectively performed optimize friction draft gear design linear speed achieved using parallel computing cut computing time months days optimized results using pmopso pmoga agreement pareto fronts identified provide technical evidence railway manufacturers operators
field meta materials engineering asymptotic homogenization proven valuable tool estimate material properties many different design needs homogenization used design object tie global material properties local material microstructure meta material governing equations theory derived small parameter expansion assumes scaling length unit cell smallest repeatable structure found material much smaller entire material length scale however design problems meet scaling requirement meta material properties given homogenization may inaccurate leading error material design process demonstrate limitations general set macroscopic analyses derived average stress average strain theorems applied several designs assumptions homogenization theory longer valid chiefly materials made single layers unit cells applying materials analyses simple design problems necessity using meta material design method link global local properties manner consistent global design methods demonstrated particular use homogenization designing single layer materials shown incur large error design process whereas averaging method much accurate published elsevier ltd
purpose eczema may flare bacterial infection evidence supporting antibiotic treatment low quality aimed determine effect oral topical antibiotics addition topical emollient corticosteroids children clinically infected eczema methods employed arm blinded randomized controlled trial ambulatory care children clinical non severely infected eczema randomized receive oral topical placebos control oral antibiotic flucloxacillin topical placebo topical antibiotic fusidic acid oral placebo week compared patient oriented eczema measure poem scores weeks using analysis covariance ancova results randomized children control oral antibiotic topical antibiotic mean baseline patient oriented eczema measure scores control group oral antibiotic group topical antibiotic group baseline children following findings weeping crusting pustules painful skin mean poem scores weeks control oral antibiotic group topical antibiotic group controlling baseline poem score neither oral topical antibiotics produced significant difference mean poem scores respectively significant differences adverse effects serious adverse events conclusions found rapid resolution response topical steroid emollient treatment ruled clinically meaningful benefit addition either oral topical antibiotics children seen ambulatory care mild clinically infected eczema need treatment antibiotics
first principles calculations based density functional theory reveal superior physical properties hydrogen fluorine decorated silicene hsif monolayer bilayer simulated results reveal hsif monolayer large direct band gap semiconductor greatly differing gap less semi metallic silicene exists strong interlayer coupling hsif bilayer leading good stabilities hsif bilayer even beyond bilayer graphene proposed hsif bilayer exhibits moderate direct band gap much lower hsif monolayer encouragingly hsif layers direct band gap nature irrespective stacking pattern thickness external electric fields advantage mos layers furthermore plane electric field evident impact band structures hsif monolayer bilayer especially band gap hsif bilayer effectively tuned external electric field even semiconductor metal transition occurs importantly hsif bilayer exhibits significant improved visible light adsorption peak respect hsif monolayer superior optical properties robust independent stacking pattern complete electron hole separation also enhances photocatalytic efficiency hsif bilayer word moderate band gap effective band gap modification external electric field robust direct band gap nature suitable band edge positions electron hole separation fascinating visible light adsorption enable hsif bilayer great potential applications field solar energy conversion high performance photocatalysis nanoelectronic devices call concern kind janus materials possesses excellent properties elsevier rights reserved
despite many reports visual processing deficits psychotic disorders studies needed integration visual non visual components eye movement control improve understanding sensorimotor information processing disorders non visual inputs eye movement control include prediction future target velocity extrapolation past visual target movement anticipation future target movements unclear whether non visual input impaired patients schizophrenia recorded smooth pursuit eye movements patients schizophrenia spectrum disorder patients bipolar disorder controls foveo fugal ramp task target either continuously visible blanked movement determined peak gain measuring overall performance initial eye acceleration measuring visually driven pursuit deceleration target extinction measuring prediction eye velocity drifts onset target visibility measuring anticipation residual gain blanking intervals measuring anticipation prediction patient groups initial eye acceleration decreased ability adjust eye acceleration increasing target acceleration impaired contrast neither deceleration eye drift velocity reduced patients implying unimpaired non visual contributions pursuit drive disturbances eye movement control psychotic disorders appear consequence deficits sensorimotor transformation rather pure failure adding cognitive contributions pursuit drive higher order cortical circuits generally deficit might reflect fundamental imbalance processing external input acting according internal preferences
purpose systematically analyse randomised controlled trials rcts efficacy safety proliferative injection therapy prolotherapy treatment osteoarthritis methods central embase medline searched two reviewers independently conducted screening data extraction rcts assessed cochrane risk bias tool type treatment study design dosing efficacy outcomes safety outcomes analysed protocol registered prospero crd results seven rcts included participants aged years mean pain duration three months eight years follow weeks months studies analysed knee joint first carpometacarpal joint finger joints various types prolotherapy used dextrose commonly used irritant agent studies concluded prolotherapy effective treatment serious adverse events reported studies considerable methodological limitations discussion limited evidence low quality studies indicates beneficial effect prolotherapy management number participants studies small provide reliable evidence conclusions current data trials prolotherapy considered preliminary future high quality trials topic warranted
investigation correlation way life women secular devoted belonging christian orthodox fraternity stress management skills sample population consisted women belonging orthodox christian fraternity secular women years age older wider thessaloniki area north greece antonovsky scale sense coherence soc used stress management skills evaluation mean soc score secular devoted women presence strong sense coherence women belonging fraternity older age correlate higher soc scores religiousness appears enhance stress management skills women although additional evidence needs support findings research
adverse conditions fetal life associated structural functional changes neurodevelopment neonatal period adolescence study connectomics used assess evolution brain networks infancy early adolescence brain network reorganization time subjects suffered adverse perinatal conditions characterized related neurodevelopment cognition three cohorts prematurely born infants children weeks gestational age including individuals birth weight appropriated gestational age intrauterine growth restriction iugr evaluated years age respectively common developmental trajectory brain networks identified control iugr groups network efficiencies fractional anisotropy weighted normalized connectomes increase age related maturation myelination fiber connections number connections decreases associated axonal pruning process reorganization comparing subjects without iugr similar pattern network differences groups observed three developmental stages mainly characterized iugr group reduced brain network efficiencies binary weighted connectomes increased efficiencies connectome normalized total connection strength associations brain networks neurobehavioral impairments also evaluated showing relationship different network metrics specific social cognition related scores well higher risk inattention hyperactivity executive functional disorders iugr children
objective given importance emotion regulation aetiology maintenance psychopathology investigated subjective reports group bipolar individuals compared results group depressed healthy control participants additionally explored impact psychotropic medication method participants diagnosed bipolar disorder participants diagnosed major depression healthy controls administered multifaceted measure also explored impact antidepressants explored whether amount psychotropic medication differential effect results participants scored significantly higher groups overall ders suggesting predictably diagnostic groups difficulties regulating emotions additionally comparing groups participants depression showed difficulties acceptance engaging goal directed behaviour impulsivity access effective strategies contrast participants showed selective difficulties accessing emotion regulation strategies compared group exploratory part study failed find positive effect antidepressants impact amount psychotropic medications conclusions difficulties regulating emotions differentiate healthy controls diagnostic groups furthermore participants showed less difficulties regulating emotions still difficulties assessment differences appears possible multifaceted measure utilised additionally results showed antidepressants improve overall amount medication associated although robust conclusions regarding medications possible exploratory part study appears precise effect psychotropic including antidepressants area need research
currently interest electric vehicles evs exhibited automakers government agencies customers make attractive research due carbon dioxide emitted conventional combustion engine worsens greenhouse effect nowadays since electric motors core evs pressing need researchers develop advanced electric motors one candidates switched flux machine sfm initiated order cope requirement paper proposes new alternate circumferential radial flux aciraf permanent magnet switched flux machines pmsfm light weight electric vehicles firstly alciraf pmsfm compared conventional pmsfm based design restrictions specifications design refinements techniques conducted using deterministic optimization method order improve preliminary performance machine finally optimized machine design achieved maximum torque power respectively slightly better conventional pmsfm
delusions misperceptions body conspicuous feature numerous neurological psychiatric conditions stark contrast pathological cases immediacy familiarity ordinary experience body make seem representation body highly accurate even infallible recent research begun demonstrate however large systematic distortions body representation normal part healthy cognition describe research focusing distortions body representations underlying tactile distance perception position sense also discuss evidence distortions higher order body representations conscious body image finally end discussion potential relations among different body representations distortions
paper aimed explore potential mechanism underlying atopic dermatitis association asthma balb mice randomly assigned three groups including vehicle control group group treatment group mice model successfully constructed group dermatitis severity scores skin lesions significantly increased mice dncb application airway responsiveness group significantly higher group number inflammatory cells increased skin lesions bronchoalveolar lavage fluid balf mice levels ifn gamma ova ige balf supernatants mice group higher group changes mice decreased tacrolimus results indicate may significant risk factor atopic asthma development
study developed computational fluid dynamics cfd model turbocharged diesel engine powered diesel fuel engine part power generating set portable version simulation tests analyzed impact ignition timing thermodynamic parameters emissions toxic components verified model test engine used optimize thermal cycle test engine found engine model acceptable accuracy suitable emissions modeling full load emissions gikwh satisfied euro criteria load increased soot emissions also increased model also confirmed dynamics soot formation opposite formation summary cfd modeling provides powerful tool optimizing internal combustion engine terms thermodynamic parameters emissions model test engine produced using avl fire elsevier inc rights reserved
aim analyze epidemiological clinical laboratory findings infectious keratitis methods retrospective study cases infective keratitis attended institution mar feb done mansoura ophthalmic center egypt corneal scrapings performed processed direct microscopy culture appropriate media using standard laboratory protocols results patients enrolled study corneal scrapings obtained ocular trauma common predisposing factor followed diabetes mellitus cultures positive scraping samples samples pure fungal infection pure bacterial infections mixed fungal bacterial growths acanthamoeba detected samples common fungal pathogen aspergillus spp common bacterial isolates staphylococcus aureus pseudomonas aeruginosa conclusion incidence fungal keratitis high region therapeutic approach initially based clinical features sensitivity resistance patterns microbiological research direct antimicrobial treatment antibiotic resistance fluoroquinolones aminoglycosides important consideration
aims objectivesto examine attitudes knowledge beliefs homosexuality nurses allied professionals two early parenting services australia backgroundearly parenting services employ nurses allied professionals access inclusion policies important community health early childhood service settings however little known perceptions professionals work within early parenting services relation lesbian gay bisexual transgender families designthis final series studies undertaken two early parenting services two states australia using cross sectional design quantitative qualitative approaches methodsvalidated questionnaires completed nurses allied professionals tested chi squared test independence fisher exact test mann whitney test kruskal wallis one way analysis variance spearman rank correlation thematic analysis examined qualitative data collected box free comments resultsof constructs measured questionnaires significant relationships found knowledge attitude gay affirmative practice scores sociodemographic variables professional group however attitude scores towards lesbians gay men significantly negatively affected conservative political affiliation held religious beliefs frequency praying six overall themes found follows respect parenting role implications child management disclosure resources training conclusionsthe study provided depth analysis attitudes knowledge beliefs professionals two early parenting services showing work needed promote acceptance diversity inclusion lesbian gay bisexual transgender families planning developing evaluating accessing early parenting services relevance clinical practiceaccess inclusion plans lesbian gay bisexual transgender families crucial early parenting services australia included professional development programmes
gauss bonnet holographic fluid useful theoretical laboratory study effects curvature squared terms dual gravity action transport coefficients quasi normal spectra analytic structure thermal correlators strong coupling understand behavior possible pathologies gauss bonnet fluid dimensions compute analytically non perturbatively gauss bonnet coupling second order transport coefficients retarded two three point correlation functions energy momentum tensor hydrodynamic regime well relevant quasi normal spectrum haack yarom universal relation among second order transport coe fficients violated second order gauss bonnet coupling zero viscosity limit holographic fluid still produces entropy momentum usion sound attenuation suppressed orders hydrodynamic expansion adding higher derivative electromagnetic field terms action also compute corrections charge diffusion identify non perturbative parameter regime charge diffusion constant vanishes
skeletal muscle represents largest organ body comprises body weight recently recognized endocrine function proteins expressed released muscle autocrine paracrine endocrine bio activities termed myokines likely muscle contraction represents primary stimulus synthesis secretion myokines enable communication organs liver adipose tissue brain auto regulation muscle metabolism date several hundred myokines muscle secretome identified sub population specifically induced skeletal muscle contraction however bioactivity many myokines mechanism act either yet characterized remains poorly understood physical activity exercise recognized central tenet prevention treatment type diabetes recent data suggest humoral factors muscle derived secretory proteins may mediate beneficial effects exercise treatment metabolic diseases mini review aims summarize current knowledge role contraction induced myokines mediating beneficial effects physical activity exercise prevention treatment specifically glucose lipid metabolism future directions optimize contraction induced myokine secretion inform exercise protocols prevention treatment also discussed
background understanding molecular mechanisms underlying alzheimer disease remains incomplete previous studies revealed genetic factors provide significant contribution pathogenesis development past years numerous genes implicated disease identified via genetic association studies candidate genes genome wide level however many cases roles genes interactions still unclear comprehensive systematic analysis focusing biological function interactions genes context therefore provide valuable insights understand molecular features disease method study collected genes potentially associated screening publications genetic association studies deposited pubmed major biological themes linked genes revealed function biochemical pathway enrichment analysis relation pathways explored pathway crosstalk analysis furthermore network features related genes analyzed context human interactome specific network inferred using steiner minimal tree algorithm results compiled human genes reported associated publications biological theme analysis indicated biological processes biochemical pathways related neurodevelopment metabolism cell growth survival immunology enriched genes pathway crosstalk analysis revealed significantly enriched pathways could grouped three interlinked modules neuronal metabolic module cell growth survival neuroendocrine pathway module immune response related module indicating specific immune endocrine neuronal regulatory network furthermore specific protein network inferred novel genes potentially associated identified conclusion means network pathway based methodology explored pathogenetic mechanism underlying systems biology level results work could provide valuable clues understanding molecular mechanism underlying addition framework proposed study could used investigate pathological molecular network genes relevant complex diseases phenotypes
explored rates hepatitis virus hbv human immunodeficiency virus hepatitis virus syphilis vulnerable population mostly intravenous drug users sex workers homeless people focused factors associated failure return results ftr false perception immunization hbv performed prospective multicenter observational study nine mobile hospital areas screening located paris january december total patients recruited proportion ftr results multivariate analysis unemployment significantly associated ftr well screened past patients immunization hbv multivariate analysis one place residence protected screened past enhanced risk rate ftr problem use currently available technologies phone texting might partial solution conjunction rapid tests diagnosis addition information comprehension results provided together specific anti hbv vaccination campaigns targeting specific populations
information security key important trying interconnect wireless body sensor network healthcare social network via mobile facilities paper specially work secured electrocardiogram ecg signal transmission scheme prevent injuries patients heart diseases human emotional stress proposed dynamic encryption method via biometric information among frequency spectrums ecg signals guarantee high classification rate system energy efficiency time cooperative relays applied additional spatial diversity gains simulation results show improved transmission rate signal power capacity lower probability data intercept lpi detection lpd taking advantages temporal spatial diversities network security thereby improved
risk epidemics emerging emerging diseases avian flit tuberculosis malaria vector borne diseases rising risks contained prevention early warning prompt management despite progress information technology communication still bottleneck health early warning response systems post disaster situations paper presents satellites epidemiology safe component based interoperable architecture health early warning employs satellite radio wireless networks geographic information systems integration technology data mining promptly identify respond disease outbreak post disaster situation mobile health emergency coordination center established integrated public health services health monitoring added value safe post disaster health management demonstrated part earthquake readiness exercise regarding typhoid fever epidemic island crete advanced communication data mining techniques safe offer new tools epidemic intelligence contribute advanced preparedness prompt response lifting communication barriers promoting collaboration reducing isolation affected areas
relationship seasonal affective disorder sad subjective quality sleep wake cycle adolescents explored seasonal pattern assessment questionnaire children adolescents spaq mini sleep questionnaire msq administered adolescents living city cesena emilia romagna region italy females age range years determine sad perceived quality sleep wake cycle response rate females males msq includes two factors sleep wake lower scores corresponding lower quality sleep wake msq includes cut criteria detect good bad sleep wake quality adolescents sad scored significantly lower affected wake factor effect observed sleep factor sad one significant predictor good bad wake quality reach significant level reference good bad sleep quality present results indications possible influence sad wake quality studies necessary confirm elsevier ireland ltd rights reserved
current literature adolescent problematic internet use piu provide adequately comprehensive picture possible dynamics different aspects life shaping piu particularly currently unknown socioeconomic background could exert indirect influences adolescents particular social strata require assistance remain unidentified based problem behavior theory conceptual model three layers namely socioeconomic indicators school related psychosocial variables pattern internet use formulated tested survey data students two hong kong secondary schools path analysis conducted yield explanatory model piu findings suggested two different roles socioeconomic background plays first potentially exerts influence antecedent intermediary determinants educational stress second potentially moderates mechanism particular found parental education family income significantly moderate association amount internet use severity piu according findings public health policies could focused adolescents belonging certain social strata require additional assistance also school policies parenting strategies could better informed reference relevant psychosocial variables pattern internet use elsevier ltd rights reserved
first bridge ebro river delta recently constructed substituting barge service bridge called passador homage old guiders barges built protected environmental site great touristic potential connecting two riverside villages separated river constructed structure winner design competition consists slender self anchored suspension bridge spans suspended four parabolic cables central web resembling sail boat web naturally divides wide cross section two equal parts one reserved vehicles two lanes pedestrians bicycles creating useful path connecting two villages amazing views river slender pseudo circular piers used torsion directly resisted abutments making use torsionally stiff streamlined steel box girder section steel towers specifically designed shallow concordance shallow fields delta surroundings structural consequence stress variation cables due live load minimized making possible use conventional prestressing technology cables greatly reduces cost simplifies details saddles self anchored bridges usually built scaffolding possible river alternatively evolutive construction sequence used including lifting central part long stayed cantilevers opening bridge eagerly awaited citizens two villages use wide pedestrian path distinctly changed relationships
backgroundin japan students poor adjustment school life school refusals recognized nation wide problem study examined link absence mothers active engagement infants months children risks poor adjustment toward elementary school life ages methodswe used japanese national longitudinal survey years follow social patterning mothers engage infants employed propensity score matching analyses control confounding socio economic factors matched mothers active engagement without various social parental characteristics educational attainment household income results conclusionsamong matched pairs observed higher risks poor adjustment school life years among japanese children lacked mothers active engagement months example relative risk confidence interval inability get along others group setting age years inability get along teachers age years findings corroborate previous findings emphasize importance providing enriched environment infants social development may indicate need intervention caregivers lack appropriate nurturing skills
systematic review scientific articles violence women situations women treated traditional prism gender roles spanish films presented investigation allowing situations aggressive acts remain framed exclusively domestic sphere surprisingly articles film reviews focus women roles women violence famous film amanece que poco jose luis cuerda even mentioned simple example spanish film gender violence evident
photoexcitation dynamics chnh pbi thin films studied nanosecond time resolved photoluminescence transient photoinduced absorption excitation intensity similar similar free carrier dominant photoexcitation species however intermediate excitation intensity similar similar small fraction photoexcitations excitons however responsible within excitation intensity range branching ratio excitons free carriers estimated furthermore spectral narrowing found low temperature formation excitons indicating laser action could due excitonic emission findings provide fundamental insights optical properties organometal halide perovskites direct implications optoelectronics
real time cooperative communication based wireless network presented monitoring health activity end user environment cooperative communication offers better energy consumption also opportunity aware current location user non intrusively link mobile sensor node relay node dynamically established using received signal strength indicator rssi link quality indicator lqi based adaptive relay selection scheme study proposes linear acceleration based transmission power decision control tpdc algorithm enhance energy efficiency cooperative communication occurrences false alarms carefully prevented introducing three stages sequential warning system real time experiments carried using nodes namely mobile sensor node relay nodes destination node indigenously developed using microcontroller integrated built transceiver mhz wireless node performance characteristics energy consumption signalnoise ratio snr bit error rate ber packet delivery ratio pdr transmission offset evaluated participated nodes experimental results observed proposed linear acceleration based transmission power decision control algorithm almost doubles battery life time energy efficient conventional cooperative communication
background approach low density lipoprotein cholesterol ldl lowering becomes increasingly intensive accurate assessment ldl low levels warrants closer attention individualized clinical efficacy safety evaluation aimed assess accuracy ldl estimation low levels friedewald equation facto clinical standard compare accuracy novel big data derived ldl estimate methods individuals friedewald ldl compared accuracy friedewald novel ldl values relation direct measurements vertical auto profile ultracentrifugation examined differences estimate minus ultracentrifugation classification according levels initiating additional safety precautions per clinical practice guidelines results friedewald values less ultracentrifugation measurement median difference percentile respective values novel estimation among friedewald ldl classification discordantly low individuals compared novel estimation conclusions estimation even lower ldl values friedewald novel methods even inaccurate often friedewald value underestimated translates unnecessary safety alarms could reduced half estimation using novel method
continued increase production scale chicken industry led increased use chicken manure fertilizers landfill disposal leads land water pollution eutrophication landfills thus although chicken manure rich ash moisture content thermochemical waste energy techniques gasification chicken manure makes efficient alternative energy source clean waste management role oxygen addition steam gasification chicken manure different concentrations examined evolutionary behavior gases evolved time analyzed using gas chromatography isothermal conditions maintained semi batch reactor temperature oxygen concentration increased dry basis oxygen concentrations examined addition oxygen decreased reaction duration improving syngas characteristics energy yield short periods reduction energy yield limited minimal amounts varied reduction directly proportional oxygen content gasifying agent accumulative yield carbon monoxide maximum oxygen concentration dry basis extra oxygen concentration caused oxidation syngas components decrease energy content syngas yield results revealed reduction net energy requirements decreasing reaction time oxygen content minimal reduction energy content syngas yield improved carbon conversion results provide improved design strategies better waste energy technique addition oxygen steam gasification chicken manure elsevier ltd rights reserved
considerable evidence identified biased cognitive processing alcohol related stimuli important factor maintenance alcohol seeking relapse among individuals suffering alcohol use disorders auds addition large body research demonstrated exposure alcohol cues elicit powerful alcohol cravings little known however possible relationship attentional bias cue induced cravings even less known processes social drinkers without personal history auds goal study examine possibility attentional biases toward alcohol related stimuli would predict elevated cue induced alcohol craving population young adult social drinkers mean age female recruited urban university population completed visual dot probe task presented alcohol neutral stimulus pictures immediately followed visual probe replacing one pictures attentional bias measured calculating reaction times probes replaced alcohol stimuli neutral stimuli participants completed classic alcohol cue exposure task reported cravings immediately alcohol neutral cue exposures surprisingly exposure alcohol cues elicited significant cravings consistent study hypothesis larger attentional biases toward alcohol stimuli predicted higher levels alcohol craving findings demonstrate heightened attention alcohol stimuli significantly impact motivation consume healthy young adults suggest possible pathway linking cognitive processes early drinking trajectory later development auds elsevier ltd rights reserved
heuristics metaheuristics achieved great accomplishments various fields investigation relationship algorithms problem hardness hot topic research field related research work contributed much understanding underlying mechanisms algorithms problem solving however existing studies consider traditional combinatorial problems case studies study taking next release problem nrp requirements engineering case study investigate relationship software engineering problem instances heuristics employ evolutionary algorithm evolve nrp instances uniquely hard easy target heuristic greedy randomized adaptive search procedure randomized hill climbing paper use feature based method estimate hardness evolved instances respect target heuristic experimental results demonstrate evolutionary algorithm used evolve nrp instances uniquely hard easy solve moreover features enable estimation target heuristics performance
substance use disorders sud mental health disorders significant public health issues occur associated high risk suicide attempts sud mental health disorders prevalent among offenders prisoners inmates non imprisoned population raising concerns risk self harm cross sectional study examined population state prison system identify associations among sud alcohol cannabis intravenous drugs narcotics tobacco smoking mental health disorders anxiety bipolar depression psychotic disorders suicide attempts primary aim determine groups sud mental health disorders occurrences strongly association suicide attempts groups documented sud mental health disorders compared peers without issues greater odds respectively attempting suicide significant conditions also significant differences within sud mental health disorders groups regard suicide attempts groups greatest odds suicide attempts offenders comorbid bipolar comorbid anxiety alcohol combined depression cannabis occurring depression documentation suicide attempts imprisonment indicates awareness also suggest need continue enhancing screening evaluating environmental settings
ageing primary risk factor cognitive deterioration given cerebral blood flow cbf regulation cerebral circulation attenuated elderly could expected ageing induced cognitive deterioration may affected decrease cbf result brain ischemia energy depletion cbf regulation associated cerebral metabolism thus likely plays important role preservation cognitive function however specific conditions exercise change cbf synchronize cerebral metabolism recent study demonstrated cognitive function strongly affected changes cerebral metabolism changes cbf exercise therefore remains unclear alteration cbf regulation affects cognitive function review summarize current knowledge previous investigations providing possibility interaction regulation cbf cerebral metabolism cognitive function
synthetic aperture radar sar interferometric sar insar provide structural electromagnetic information ground surface therefore widely used land cover classification however relatively studies developed analyses investigate sar datasets richly textured areas heterogeneous land covers exist intermingle short distances one main difficulties shapes structures sar image represented detail mixed pixels likely occur conventional insar parameter estimation methods used solve problem extend previous research remote monitoring urban environments address use accurate insar covariance matrix estimation improve accuracy land cover mapping standard updated methods tested using polarization terrasar dataset compared using random forest classifier detailed accuracy assessment complied six types surfaces shows updated method outperforms standard approach around overall accuracy areas rich texture zhuhai china paper demonstrates accuracy land cover mapping benefit enhancement quality observations addition classifiers selection multi source data ingratiation reported previous studies international society photogrammetry remote sensing inc isprs published elsevier rights reserved
background micrornas group small rnas regulate gene expression posttranscriptional level regulate almost every aspect cellular processes study investigated whether mir regulates pulmonary fibroblast activation results found mir regulated fibrotic lungs fibroblasts experimental mouse model pulmonary fibrosis overexpression mir lentiviral vector inhibited tgf beta stimulated mrna expression collagens cola cola cola alpha smooth muscle actin protein expression cola alpha smooth muscle actin human pulmonary fibroblasts mir also reduced contractile activity tgf beta receptor smad identified targets mir untranslated region luciferase reporter western blotting assays conclusions results suggest mir anti fibrotic microrna inhibits fibroblast activation targeting tgf receptor smad discovery may provide new targets therapeutic interventions idiopathic pulmonary fibrosis
digital control achieved success various power electronic applications data conversion remains primary challenge limitation compared conventional analog methods particular tradeoffs among resolution switching frequency power consumption digital pulse width modulation dpwm blocks limit performance particularly high conversion ratio applications analog digital conversion also challenging line voltage feedforward techniques applied requires high speed accuracy cases exposure voltages exceeding rating deep submicron cmos technologies work explores tradeoffs power consumption counter delay line dpwm circuits implemented cmos derives optimization method segment bit allocation among counter delay line components method line voltage feedforward also presented instrument quantize transients supply voltage without direct exposure low voltage devices supply automotive application considered
aim study present effect lego mindstorms based design activities students attitudes towards learning computer programming self efficacy beliefs levels academic achievement research pretest posttest control group semi experimental study study group research consisted students attending faculty engineering experimental group administered teaching method lego mindstorms based design activities hand control group topics directly taught via editor research data collected via implementing academic achievement test attitude towards learning programming scale cronbach alpha computer programming self efficacy scale cronbach alpha obtained findings education using lego mindstorms design activities contributed meaningfully academic success students terms programming language compared traditional method
paper investigate generalized nonautonomous nonlinear equation describes ultrashort optical pulse propagating nonlinear inhomogeneous fiber certain integrable constraints bilinear forms bright one two soliton solutions obtained via certain transformation investigate properties solitons first order dispersion parameter sigma second order dispersion parameter sigma third order dispersion parameter sigma phase modulation gain loss soliton propagation collision graphically presented analyzed one soliton shown maintain amplitude width propagation choose sigma sigma sigma differently travelling direction soliton found alter observed affect amplitude soliton head collision two solitons presented sigma sigma sigma constants solitons amplitudes collision sigma sigma sigma chosen certain functions solitons traveling directions change collision influence amplitudes two solitons elsevier rights reserved
porous materials cover broad multidisciplinary scientific technological domain used numerous existing emerging devices processes related key societal issues environmental protection benefit economy choice illustrate advances porous materials three specific examples porous materials engineering case organic mesoporous materials prepared block polymers modeling numerical simulation adsorption molecular species nanoscale finally technological applications thermal insulators
paper studies case water pollution sweden city gothenburg struggle issue order secure source fresh water satisfy demand drinking water argued paper city employed wide variety strategies ranging water treatment acquiring property rights watershed provides water importantly city interested reducing levels pollution river consequently became key stakeholder enforcement implementation effective environmental legislation
filter media polyester one geotextile materials used aerosol drainage filtration particularly soil reinforcement civil engineering due appropriate properties low cost however current understanding durability stability material real service conditions especially severe long term conditions completely limited work presents investigation chemical aging commercial nonwoven polyester membrane different temperatures environments relation morphology mechanical properties molar mass results showed significant reduction mechanical properties term tensile strength puncture resistance tearing forces membrane aging process due chemical degradation molar mass mechanical properties changes temperature showed complex dependence material properties environmental conditions based obtained results lifetime material different temperatures determined use arrhenius model results provide useful information better understanding phenomena occurring chemical aging polyester nonwoven membranes may help predict service lifetime material conditions use encounteredin service elsevier ltd rights reserved
accurate repositioning maxillary mandibular segment essential improve esthetics function orthognathic surgery improvement three dimensional imaging technology computer aided design manufacturing techniques various computer aided design manufacturing templates developed alternatives traditional error prone time consuming intermediate splint however majority previously developed templates still use intermediate splint structures connected occlusal surface transferred preoperative virtual plan real operation field indirectly authors introduce technical note regarding maxillary surgical templates adjusted maxillary surface configuration templates consist osteotomy repositioning guide templates provide information osteotomy line bony interference planned position eliminate need intermediate splint using templates maxillomandibular complex successfully repositioned without using intermediate splint studies needed determine accuracy stability maxillary templates
backgroundauditory hypersensitivity one major complications autism spectrum disorder aim study investigate whether auditory brain center affected autism model rats methodsautism model rats prepared prenatal exposure thalidomide embryonic day pregnant rats superior olivary complex soc complex auditory nuclei immunostained anti calbindin antibody postnatal day resultsin autism model rats soc immunoreactivity markedly decreased strength immunostaining soc auditory fibers also weak autism model rats surprisingly size medial nucleus trapezoid body nucleus exerting inhibitory function soc significantly decreased autism model rats conclusionsauditory hypersensitivity may part due impairment inhibitory processing auditory brain center
three studies contribute literature dominance nonverbal behavior ellyson dovidio examining man choice shave head influences person perception study men shaved heads rated dominant similar men full heads hair study men whose hair digitally removed perceived dominant taller stronger authentic selves study extends results nonphotographic stimuli demonstrates men experiencing natural hair loss may improve interpersonal standing shaving theories signaling norm violation stereotypes examined explanations effect practical implications men psychological social economic outlooks also discussed
photothermal effect first time utilized capture energy infrared light promote photocatalytic oxidation activity simply mechanical mixing traditional photocatalysts core shell structured feo sio feo sio absorbed infrared light transferred thermal energy based photothermal effect accelerated photocatalytic activity traditional photocatalysts promotion effect led addition feo sio confirmed several classical photocatalysts tio bioi ceo quantitatively characterize photothermal effect thermo images taken thermo imager obtain average temperature rise samples illumination simulated solar light specially feo sio studied depth illustration promotion mechanism experimental results showed contribution sio shell photocorrosion feo occur photocatalytic oxidation process photothermal effect feo maintained quantity feo sio vital factor promotion photocatalytic activity optimum mass ratio feo sio min illumination temperature optimum feo sio rose degrees degrees conversion capability showed enhancement comparison pure experimental results confirmed rise temperature attributed photothermal effect contribution directly heating photocatalysts furthermore enhancement conversion capability around observed feo sio mixed anatase tio zno bioi ceo sum developed new strategy utilization nir light solar energy facilitate photocatalytic reactions elsevier rights reserved
feature description local shape presence noise varying mesh resolutions clutter occlusion quite challenging task computer vision paper tackles problem proposing new local reference frame lrf together novel triple orthogonal local depth images toldi representation forming toldi method local shape description compared previous methods toldi manages perform efficient distinctive robust description local surface simultaneously various feature matching contexts proposed lrf differs many prior ones calculation axis axis axis calculated using normal keypoint axis computed aggregating weighted projection vectors radius neighbors toldi feature descriptors obtained concatenating three local depth images ldi captured three orthogonal view planes lrf feature vectors performance toldi approach rigorously evaluated several public datasets contain three major surface matching scenarios namely shape retrieval object recognition registration experimental results comparisons state arts validate effectiveness robustness high efficiency overall superiority method method also applied aligning object indoor scene point clouds obtained different devices lidar kinect accurate outcomes confirm effectiveness method
experience childhood trauma stressful life events sles associated subsequent development variety mental health conditions including psychotic illness recent research identifying adolescents young adults clinical high risk chr psychosis allows prospective evaluation impact trauma adverse life events psychosis onset outcomes addressing etiological questions answered studies fully psychotic non clinical populations article provides comprehensive review current emerging literature trauma adverse life events chr population chr youth endorse lifetime history childhood traumatic events victimization bullying several studies shown experience predicts psychosis onset among chr individuals literature influence recent sles death loved one remains inconclusive multiple models proposed explain link trauma psychosis including stress vulnerability stress sensitivity hypotheses emphases cognitive processes neurobiological mechanisms hypothalamic pituitary adrenal axis despite preponderance chr individuals endorse either sles clinical trials conducted evaluating interventions trauma chr youth date furthermore current process formal identification assessment trauma sles impact chr youth inconsistent research clinical practice recommendations improving trauma assessment treatment future research directions chr field provided
improvements biomedical technologies combined changing social attitudes sexual minorities provide new opportunities hiv prevention among gay men sex men gmsm potential new biomedical technologies biotechnologies reduce hiv transmission impact hiv among gmsm depend part degree challenge prejudicial attitudes practices stigma directed gay men people living hiv plhiv structural level stigma regarding gay men hiv influence scale new biotechnologies negatively affect gmsm access use technologies personal level stigma affect individual gay men sense value confidence negotiate serodiscordant relationships access services paper argues maximising benefits new biomedical technologies depends reducing stigma directed sexual minorities people living hiv promoting positive social changes towards within gmsm communities hiv research policy programs need invest responding structural institutional stigma health promotion health services recognise work address impact stigma gmsm incorporation new hiv prevention biotechnologies enhanced mobilisation participation gmsm plhiv new approaches hiv prevention expanded approaches research evaluation stigma reduction relationship hiv prevention hiv response must become bolder resourcing designing evaluating programs interact influence stigma multiple levels including structural level stigma
electroconvulsive therapy ect one effective treatments severe treatment resistant major depressive disorder mdd schizophrenia ect frequently considered drug resistant cases augmehtation antipsychotic treatment cases rapid symptom relief indicated accumulating neuroimaging evidence suggests modulation medial temporal lobe prefrontal cortical regions mdd ect ect effects brain structure systematically investigated far study investigated brain volume ect naive patients mdd received right sided unilateral ect twenty one healthy controls included structural magnetic resonance imaging data acquired ect healthy participants scanned source based morphometry used investigate modulation structural networks pre post ect ect impact distinct structural networks mdd mdd sbm revealed medial temporal lobe mtl network including hippocannpus parahippocampal cortex showed significant increase ect increase mtl network strength associated clinical improvement either mdd lateral prefrontal cingulate cortical network showed volume increase ect effect accompanied clinical improvement findings provide preliminary evidence structural network change response ect mdd data suggest diagnosis specific transdiagnostic ect effects brain volume contrast mdd structural network modulation ect associated clinical improvement elsevier ecnr rights reserved
load flow studies essential task carried power system planning operations however widely used deterministic load flow analysis limited handling network uncertainties inaccuracies input data therefore probabilistic load flow plf based either numerical methods monte carlo simulation analytical method convolution techniques developed handle power system uncertainties due variations electrical network variables paper presents probabilistic load flow analysis method based convolution techniques method suitable distribution systems examines effect load generation network uncertainties either separately combinations thereof main features paper include critical appraisal existing plf techniques published literature carried derive optimised technique methodology proposed method applied practical bus radial distribution network modelled powerfactory digsilent software package results obtained exported matlab detailed statistical analysis terms various probability distribution function pdf cumulative density functions cdf
paper discusses novel method check effectiveness combining deterministic generalized orthonormal basis filters gobf stochastic autoregressive moving average arma filters state space representation effectiveness gobf models improved coupling arma model presence unmeasured disturbances work particle swarm optimization pso algorithm used determine poles gobf filter
background borderline personality disorder bpd characterised difficulties impulse control affective dysregulation unclear whether bpd contributes perpetration violence whether explained comorbidity explored independent associations categorical dimensional representations bpd violence general population differential associations individual bpd criteria methods used representative combined sample men women two british national surveys adults years bpd assessed using structured clinical interview questionnaire measured self reported violent behaviour past years including severity victims locations incidents associations binary dimensional trait level exposures performed using weighted logistic regression adjusted demography comorbid psychopathology results categorical diagnosis bpd associated intimate partner violence ipv associations serious violence leading injuries repetitive violence better explained comorbid substance misuse anxiety antisocial personality disorder aspd however anger impulsivity bpd items independently associated violent outcomes including severity repetition injury suicidal behaviours affective instability associated violence trait level severity dimensional analyses showed bpd symptoms might impact males females differently terms violence conclusions individuals diagnosed bpd violence better explained comorbidity however bpd individual traits show different pathways violence population level gender differences bpd traits severity indicate distinct underlying mechanisms towards violence bpd traits evaluated perpetrators ipv
objective test whether subjects spontaneously signal sleepiness falling asleep monotonous conditions methods twenty eight healthy students deprived sleep one night underwent maintenance wakefulness test mwt consisting four min trials told give signal soon felt sleepy try stay awake long possible first series tests subjects given reward second series monetary rewards given accurate perception sleepiness staying awake longer results seventeen subjects signal sleepiness sleep fragment occurred least one four mwt trials women reliably aware sleepiness men trials men performance improved trials becoming equivalent women performance conclusions results cast doubt general assumption one fall asleep without feeling sleepy first similar results obtained monotonous driving working situations imply accidents caused sleepiness falling asleep necessarily attributed individual negligence elsevier rights reserved
background helicobacter pylori infection present global population associated chronic gastritis peptic disease gastric malignancies prevalence crohn disease patients shown low compared general population influence disease activity yet determined aims determine prevalence selected group patients quiescent disease assess influence eradication disease activity endoscopic laboratory activity measures methods consecutive patients quiescent disease underwent meticulous disease evaluation enterography mre video capsule endoscopy vce crp fecal calprotectin cdai patients tested presence using stool antigen detection kit patients infected offered eradication treatment sequential therapy eradication confirmed using urease breath test stool antigen test influence eradication disease activity assessed results patients enrolled six patients infection five patients gastro duodenitis per vce positive patients offered eradication treatment underwent successful eradication notably patients proximal disease per vce negative cdai crp fecal calprotectin vce lewis inflammatory score change significantly following eradication gastric findings vce impacted eradication conclusions prevalence infection patients quiescent relatively low eradication bacteria significantly change neither disease activity measures presence gastro duodenitis per vce suggesting might part proximal influence activity merits investigation
recently reported compact microcontroller based unit developed accurately synchronize excimer laser pulses mingesz fluct noise lett doi shown dithering based random jitter noise plus pseudorandom numbers used digital control system radically reduce long term drift laser pulse trigger improve accuracy synchronization update paper present new experimental results obtained use delay controller unit tune timing krf excimer laser addition previous numerical simulation results hardware interfaced laser using optical signal paths order reduce sensitivity electromagnetic interference control algorithm tested simulations applied experiments found system able reduce delay uncertainty close theoretical limit performs well real applications simple compact flexible system universal enough also used various multidisciplinary applications
social communication skills considered core deficit children diagnosed autism spectrum disorder asd evidence based practices emerged address critical skills children asd largely implemented researchers teachers parents recently researchers studied paraprofessionals implementers interventions following review examines studies paraprofessionals taught implement social communication interventions young children asd seven articles met inclusion criteria evaluated respect type social communication intervention evidence effectiveness training methods components child outcomes primary intervention studies included pivotal response training prt natural language paradigm nlp incidental teaching strategies well mand training general antecedent consequent interventions studies reported improvements paraprofessional implementation fidelity chosen intervention five also reported corresponding improvements child outcomes four studies provided definitive evidence effectiveness paraprofessional training feedback training component used seven studies conjunction least one component
background children participating sports increasingly younger age contributed increased incidence knee injuries among population increased interest application patient reported outcome measures orthopaedic surgery evaluate treatment results numerous knee outcome scores including international knee documentation committee subjective form ikdc used evaluate knee although ikdc validated adults also used children lack appropriate outcome scores pediatric population address concern pediatric version ikdc pedi ikdc developed evaluated reliability validity responsiveness however normative data pedi ikdc established purpose aimed aid interpretation pedi ikdc scores characterizing normative data children adolescents validate pedi ikdc examining differences scores among children history knee surgery limited activity compared study design cross sectional study level evidence methods conducted cross sectional survey children adolescents aged years living united states recruited orc international obtain equal numbers participants sex integer age group participants asked complete pedi ikdc study designated index knee right left provide demographic data information knee surgery history recent week activity limitations raw pedi ikdc total scores rescaled scale used nonparametric wilcoxon kruskal wallis tests compare subgroup scores used van elteren test adjust age unadjusted adjusted values similar unadjusted values reported results number respondents uniform respect age sex age represented years fifty percent respondents female forty nine states plus washington represented addition respondents identified white non hispanic respectively seven percent respondents respondents reported prior surgery knees surgeries index knee pedi ikdc score distribution skewed left mean score median scores reached ceiling value participants reported prior surgery limited activity index knee median pedi ikdc scores approximately points lower participants without histories comparisons contrast although statistically significant variation age race ethnicity level sports exercise participation much smaller ranges median scores significant differences scores terms respondent sex geographic region conclusion normative pedi ikdc scores determined study strong association pedi ikdc scores prior knee surgery well recent activity limitations index knee used evaluate clinical outcomes supports construct validity pedi ikdc large ceiling effect scores maximum value lack sex based effect minor variation age simplify interpretation use pedi ikdc therefore pedi ikdc score distributions provide assumptions use sample size power calculations research
background adrenal glands essential endocrine organs composed two embryological distinct tissues morphological changes development well described less understood regard molecular mechanisms identify proteins pathways drive initial steps specification endocrine function adrenal gland rat adrenal glands isolated different embryonic days postnatal day results alteration proteome stages investigated combining two dimensional gel electrophoresis mass spectrometric analysis excised protein spots spots identified resulting non redundant proteins ontogenic classification identified proteins according molecular function resulted different categories whereas classification biological processes resulted different groups gives insight complex mechanisms underlying adrenal gland development interestingly expression retinoic acid pathway proteins decreased development adrenal gland suggesting pathway important early stages hand key proteins cholesterol synthesis increased expression significantly revealing initiation endocrine specialization adrenal glands conclusions study presents first comprehensive wide proteome analysis three different stages embryonic adrenal gland development identified proteins expressed early stages development shed light molecular mechanisms underlying embryonic development adrenal gland
objectivesunscreens commonly used protect body damage caused light components organic sunscreens shown pass skin wear could raise toxicity concerns compounds study explores potential oils fruit vegetable juices substitutes compounds methodsthe absorptivity various oils canola oil citronella oil coconut oil olive oil soya bean oil vitamin well aloe vera fruit vegetable juices acerola beet grape orange carrot purple carrot raspberry measured vitro mean absorptivity compared fda approved absorbers gauge potential natural products promising candidates incorporated formulations transmittance thick film formulation measured formulations also imaged light microscopy scanning electron microscopy resultsthe absorptivity oils least two orders magnitude lower compared commercial blockers fruit juice powders effective blocking still showed order magnitude lower absorptivity compared commercial blockers conclusionthe blocking natural oils insufficient obtain significant protection formulations containing purple carrot showed good blocking capabilities represent promising ingredient sunscreen cosmetic applications resume objectifles ecrans solaires sont couramment utilises pour proteger corps contre les dommages causes par lumiere ete demontre que certains composants filtres solaires organiques peuvent passer travers peau lors application qui pourrait soulever des problemes toxicite ces composes cette etude explore potentiel pour les huiles les fruits jus legumes comme des substituts pour ces composes methodesla capacite absorption differentes huiles huile canola huile citronnelle huile coco huile olive huile soja vitamine ainsi que aloe vera les fruits jus legumes acerola betterave raisin orange carotte carotte pourpre framboise ete mesuree vitro capacite absorption moyenne ete comparee des absorbeurs approuves par fda pour evaluer potentiel des produits naturels les candidats les plus prometteurs ont ete incorpores dans les formulations facteur transmission film epaisseur formulation ete mesure les formulations ont egalement ete observees par microscopie optique microscopie electronique balayage resultatsla capacite absorption des huiles etait moins deux ordres grandeur plus faible par rapport aux bloqueurs commerciaux les poudres jus fruits etaient plus efficaces pour blocage des mais encore ont montre une capacite absorption ordre grandeur plus faible par rapport bloqueurs commerciaux conclusionle blocage plupart des huiles naturelles est insuffisante pour obtenir une protection significative les formulations contenant poids carotte violette ont montre une bonne capacite blocage representent ingredient prometteur pour creme solaire des applications cosmetiques
student learning approaches identified instructor remove mitigate factors encourage surface learning develop course encourage deep learning instructors organize appropriate learning activities ensure students engage active learning civil engineering students likely develop deep approach toward learning therefore identifying civil engineering students learning approaches important factor academic success present study examined learning approaches civil engineering students three universities turkey extent learning approaches related gender age type university year study construction management course success data collected civil engineering students undergraduate programs three different universities using revised two factor study process questionnaire spq questionnaire directly administered students participants responded survey study findings revealed week correlations learning approaches age year education moderate correlations learning approaches construction management success
ethylhexyl phthalate dehp commonly used phthalates concerns adverse effects prenatal dehp exposure neonatal thyroid hormone neurodevelopment increasing however report regarding association prenatal dehp exposure infant neurodevelopment including levels japanese population thus aim present study evaluate associations prenatal dehp exposure mental psychomotor development infants months along investigating influence neonatal free thyroxine thyroid stimulating hormone tsh levels prospective birth cohort study maternal blood samples collected weeks gestation analyzed mono ethylhexyl phthalate mehp metabolite dehp levels neonatal tsh obtained mass screening data infant neurodevelopment assessed bayley scale infant development second edition month age final analysis participants included median levels maternal mehp neonatal tsh respectively find associations prenatal dehp exposure neonatal levels infant mental psychomotor development month study prenatal dehp exposure showadverse effects infant levels mental psychomotor development early life stage however previous study revealed negative effects prenatal dehp exposure sex hormone levels continuous investigation neurodevelopment later life association prenatal dehp exposure necessary published elsevier
philadelphia negative myeloproliferative neoplasms negative mpn comprise heterogeneous group chronic hematologic malignancies quality life morbidity mortality patients mpn primarily affected disease related symptoms thromboembolic hemorrhagic complications progression myelofibrosis acute leukemia major bleeding represents common important complication mpn incidence bleeding events become even relevant future due increasing disease prevalence survival mpn patients review discusses causes differential diagnoses prevention management bleeding episodes patients mpn aiming defining updated standards care often challenging situations
central feature meaning life consideration oneself extend logic suggest altruistically motivated prosociality acting ways benefit others self transcending action may provide meaning life study provided evidence relationship self reported prosocial behavior meaning life even statistically controlling personality traits self esteem study provided evidence engaging prosocial action via writing notes gratitude increased meaning life study provided evidence individuals bolster perceptions prosociality following threats meaning study suggested relationship satisfaction partially mediates link prosocial actions meaning life studies provide initial evidence prosociality enhances meaning life
test hypothesis initial evaluation patients suspected coronary artery disease cad stress myocardial perfusion imaging mpi would result less downstream testing coronary computed tomographic angiography ccta international randomized trial mildly symptomatic patients intermediate likelihood cad asymptomatic patients intermediate risk cardiac events underwent either initial stress rest mpi ccta primary outcome downstream noninvasive invasive testing months secondary outcomes included cumulative effective radiation dose erd costs months recruited patients mpi cta centers countries initial mpi abnormal ccta patients fewer patients undergoing initial stress rest mpi downstream testing months adjusted small increase median cumulative erd mpi msv difference costs two strategies months management patients suspected cad strategy initial stress mpi substantially less likely require downstream testing initial testing ccta
objective serum concentrations estradiol testosterone testo measured mass spectrometry based assays remain centile measured testo normal postmenopausal women order avoid risk non physiological systemic exposure elevated serum concentrations two sex steroids methods serum testo well dehydroepiandrosterone dhea nine metabolites measured time intervals first seventh days daily intravaginal administration dhea validated mass spectrometry based assays results biologically significant change individual serum concentrations testo dhea observed importantly estrone sulfate glucuronidated androgen metabolites also remained within normal values thus confirming absence biologically significant systemic exposure line intracrinology using data literature comparison made serum normal postmenopausal values following administration tablets conclusion clinical program vulvovaginal atrophy shown efficacy safety intravaginal dhea prasterone present data illustrate detail serum levels individual sex steroids metabolites derived dhea data obtained line physiology intracrinology confirm action limited vagina serum concentrations sex steroids maintained within normal values menopause thus protecting uterus likely tissues
oral food challenges essential diagnosing food allergies correctly however decision proceed oral food challenge complex influenced different factors procedures conducted allergy specialized centers require careful preparation besides performed double blind placebo controlled blinding food challenging limited amount type food interpretation results challenge important positive also negative results discussed patients dietary implications food avoid ance introduction provided desirably dietician
paper explore nature confabulatory explanations action guided implicit bias claim explanations significant epistemic benefits spite obvious epistemic costs benefits otherwise obtainable subject time explanation offered start outlining kinds cases mind characterising phenomenon confabulation focusing common features introduce notion epistemic innocence capture epistemic status cognitions obvious epistemic faults significant epistemic benefit cognition epistemically innocent delivers epistemic benefit subject would attainable otherwise alternative less epistemically faulty cognitions could deliver benefit unavailable subject time ask whether confabulatory explanations actions guided implicit bias epistemic benefits whether genuine alternatives forming confabulatory explanation circumstances subjects confabulate basis analysis confabulatory explanations actions guided implicit bias argue explanations potential epistemic innocence conclude epistemic evaluation confabulatory explanations action guided implicit bias ought tell richer story one takes account context explanation occurs published elsevier inc
ability encapsulate photo active guest molecules within pores metal organic frameworks mofs affords opportunity develop robust photocatalysts well solar energy conversion systems important criteria systems stability new materials towards moisture high temperatures etc preclude use many mof frameworks ability encapsulate bipyridine bpy cavities zirconium based mof uio well photophysical properties complex reported ray powder diffraction data orange uio powder consistent formation uio presence bpy steady state emission exhibits significant bathochromic shift ethanol uio corresponding emission decay encapsulated bpy complex biexponential fast component slower component deg slow component consistent encapsulation bpy cavities restricted volume prevents population triplet ligand field transition anti bonding respect bonds origin fast component unclear may involve interactions bpy encapsulated within large cavities formed missing ligand defect sites within uio materials encapsulated quenchers contained within larger cavities gives rise reduced lifetimes bpy complexes
study examines prevalence tobacco use patterns among adult social assistance beneficiaries interest quitting results based data collected cross sectional survey conducted among adults piotrkowski district sample social assistance beneficiaries produced total respondents completed face face questionnaires overall respondents including men women current smokers one third smokers reported willingness quit study population several characteristics significantly associated current daily smoking male gender low educational attainment unemployment temporary employment lack awareness smoking associated health risks use cigarettes exposure environmental tobacco smoke ets intention quit smoking among daily smokers positively correlated awareness smoking associated health risks lack previous quit attempts low exposure ets smoking prevalence among social assistance recipients tends higher general population half smokers willing quit urgency develop policies tailored needs disadvantaged population groups
electrical electronic circuit often contains special combinations circuit symbols form sub circuits identification analysis sub circuits substantially simplify underlying topology circuit paper explains maiden attempt towards topological simplification circuit identifying two important classes sub circuits one formed symbols connected series another symbols connected parallel although sub circuit usually formed type circuit symbols method handle combination irrespective symbol types method general based novel histogram analysis mathematical morphology geometric features symbol identification phase set adjacency lists representing connectivity matrix analysis phase idea may extended match topologically similar spatially different circuits using graph isomorphism may also used vectorization circuit drawings utilizing information segmented circuit elements connectivity matrices tested proposed method dataset containing scanned images variety electronic electrical drawings results presented demonstrate efficacy robustness
people socially integrated strong social ties live happier longer lives link social connection well commonly explained terms benefits receiving care support others however benefits giving care support others support provider often overlooked review emerging findings suggest giving support others provides benefits self identify possible mechanisms benefits arise outline boundary conditions influence benefits gain richer understanding association social ties well important future research direction consider support receiver also emphasize support provider
background phenotyping critical component plant research accurate precise trait collection integrated genetic tools greatly accelerate rate genetic gain crop improvement however efficient automatic phenotyping traits across large populations challenge exacerbated necessity sampling multiple environments growing replicated trials promising approach leverage current advances imaging technology data analytics machine learning enable automated fast phenotyping subsequent decision support context workflow phenotyping image capture data storage curation trait extraction machine learning classification models apps decision support carefully designed efficiently executed minimize resource usage maximize utility illustrate end end phenotyping workflow case plant stress severity phenotyping soybean specific focus rapid automatic assessment iron deficiency chlorosis idc severity thousands field plots showcase analytics framework extracting idc features set similar unique canopies representing diverse germplasm base different levels idc subsequently training variety classification models predict plant stress severity best classifier deployed smartphone app rapid real time severity rating field results investigated different classification approaches best classifier hierarchical classifier mean per class accuracy similar construct phenotypically meaningful population canopy graph connecting automatically extracted canopy trait features plant stress severity rating incorporated image capture image processing classification workflow smartphone app enables automated real time evaluation idc scores using digital images canopy conclusion expect high throughput framework help increase rate genetic gain providing robust extendable framework abiotic biotic stresses envision workflow embedded onto high throughput phenotyping ground vehicle unmanned aerial system allow real time automated stress trait detection quantification plant research breeding stress scouting applications
low permeability engineered landfill barriers often consist combination geosynthetics mineral layers even though numerical modelling software applied landfill design process lack data mechanical performance landfill barriers available validate calibrate models instrumentation installed landfill site monitor multilayer landfill lining system physical performance lining system comprises compacted clay layer overlaid high density polyethylene geomembrane geotextile sand data recorded site includes geosynthetic displacements extensometers strains fibre optics demec strain gauges extensometers stresses imposed liner pressure cells addition temperature readings collected logger installed surface geomembrane clay surface using pressure cell thermistors air temperature using thermometer paper presents readings collected throughout period three years compares measured performance corresponding numerical modelling lining system stages construction numerical modelling predictions lining system behaviour construction comparable measurements geosynthetics covered soon placement however geosynthetics left exposed sun extended period time situ behaviour geosynthetics replicated numerical analysis study highlights significant influence effect temperature geosynthetics displacements simple thermal analysis exposed geosynthetics used support explanation observed behaviour elsevier ltd rights reserved
objectives objective contribute literature regarding association immigrant children health ethnicity living neighbourhoods high ethnic concentration one ethnicity using data families five ethnic groups immigrated vancouver metropolitan region canada research question asks ethnicity ethnic concentration living neighbourhood others ethnic background contribute health immigrant children design two data sets integrated study first new canadian children youth study collected original data five ethnic groups immigrated metropolitan vancouver second data set derived neighbourhood data canadian census dependent variable health status reported parent independent variables individual neighbourhood levels including ethnicity sex percentage people living neighbourhood ethnic background analysis completed using hierarchical linear modelling results children neighbourhoods included analyses health status varied ethnicity ethnic concentration indicating heterogeneity immigrant populations conclusion lack research health immigrant children youth living ethnic concentrations findings make important contribution understanding influences well immigrant populations
nonuniform stub loaded coupling free broadband phaser proposed alternative conventional coupled line sections based phasers enhanced design flexibility reduced complexity lower cost radio analog signal processing asp systems nonuniform open short terminated stub loaded sections employed achieve specified highly flexible group delays flat transmission magnitude responses phaser require multilayer wire bonding technologies since consists couplingfree transmission lines principle synthesis procedure phaser presented two design examples diverse specifications presented theory full wave simulation results phaser realized using microstrip technology integrate different lumped components planar structures
meet stringent spectral mask requirement ieee novel spectral shaping buffer new automatic calibration proposed paper introducing floating current buffer second order intermodulation product cancelled output calibrate buffer analog signal processing methods average power extraction residual accurate quantization presented along error tolerant decision making logic sample human body communication hbc transmitter designed cmos process simulation results show spectral mask suppressed dbr satisfying ieee standard specification
background advocacy coalitions play increasingly prominent role within global health landscape linking actors institutions attract political attention resources paper examines coalitions negotiate among exercise hidden forms power produce policy basis beliefs strategic interests methods paper examines beliefs behaviours health advocacy coalitions using sabatier advocacy coalition framework acf informal theoretical lens coalitions explored relation concept transnational advocacy networks keck sikkink productive power shiffman acf focuses explaining policy change takes place conflict concerning goals technical approaches among different actors study uses participant observation methods self reported survey results semi structured qualitative interviews trace major policy project millennium development goal mdg era global strategy women children health constructed negotiations among maternal newborn child health mnch sexual reproductive health rights srhr advocacy coalitions results global strategy represented new opportunity high level political attention despite differing policy beliefs mnch srhr actors collaborated produce strategy anticipated gains political attention core beliefs shift fundamentally collaboration primarily short term tactical response time bound opportunity mnch actors began focus human rights perspectives srhr actors adopted greater use quantifiable indicators economic argumentation shift emphasises inherent importance srhr maternal child health survival conclusion opportunities arise coalitions respond based principles policy beliefs well perceptions advantage global health policy making arena contested interests power ideas shaped interaction coalitions although policy making often seen process guided evidence rather interest based politics study concludes participatory process debate among different actor coalitions vital progress lend greater legitimacy accountability transparency policy process
hyperspectral data used distinguish topsoil salt components estimate soil salinity relationship soil salt chemical components sensitive bands soil reflectance spectra analyzed correlation soil salt content soil spectra obtained hyperspectral data analyzed proving topsoil salinity significant correlation soil reflectance spectra relationship soil reflectance spectra salt chemical ions investigated soil spectral reflectance wavelength difference vegetation index selected estimate soil salinity dominant salt chemical ion concentrations depth using partial least squares regression model found bands sensitive various levels chemical components soil salt shown differ controlled dominant component soil salt sensitive bands soil salinity estimation change differences salt components estimating dominant salt soil using soil reflectance spectra lead greater prediction accuracy study provided possible method estimation salinity chemical component levels topsoil using hyperspectral data estimate topsoil salt components authors published spie creative commons attribution unported license distribution reproduction work whole part requires full attribution original publication including doi
brazil although many children low income families attend day care centers appropriate hygiene practices food programs nutritional disorders communicable diseases quantitative qualitative cross sectional study identified staff challenges child day care centers suggested alternative activity management prevent nutritional disorders communicable diseases study included nursery teachers children public philanthropic day care centers teacher child ratios respectively interviews focus groups conducted teachers parents anthropometry blood samples drawn children digital puncture children philanthropic child day care centers likely hospitalized due communicable diseases teachers philanthropic child day care centers lower age income education higher work responsibilities based number children working time focus groups characterized institutions organized routines standard food practices difficulties caretaking lack training provide healthcare children strategies improve children health day care settings focus training teachers healthcare nutrition
present study examined legal perceptions lesbian intimate partner violence ipv experimental context undergraduate women men southeastern united states read trial summary defendant charged physically assaulting sex partner trial varied whether victim defendant depicted via images either feminine masculine participants rendered verdicts made judgments victim defendant credibility results indicated victim defendant masculine feminine appearance affected judgments female participants viewed masculine victim credible feminine victim defendant masculine victim masculine viewed masculine defendant responsible victim injuries feminine defendant male participants higher sympathy masculine versus feminine victim overall anger toward masculine defendant versus feminine defendant accused assaulting feminine victim finally fewer participants mentioned defendant history violence reason guilty felony verdict feminine victim feminine defendant versus combinations victim defendant masculine feminine appearance results discussed terms gender stereotypes influencing legal decision making ipv cases among lesbian couples
structural health monitoring composite structures one important task detect identify low velocity impact events may cause invisible internal damages paper presents novel approach simultaneously identifying impact location reconstructing impact force time history acting composite structure using dynamic measurements recorded sensor network proposed approach consists two parts inner loop reconstruct impact force time history outer loop search impact location inner loop newly developed inverse analysis method bayesian inference regularization employed solve ill posed impact force reconstruction problem using state space model outer loop nonlinear unscented kalman filter ukf method used recursively estimate impact location minimizing error measurements predicted responses newly proposed impact load identification approach illustrated numerical examples performed composite plate results demonstrated effectiveness applicability proposed approach impact load identification copyright john wiley sons ltd
paper presents new electronically tunable versatile voltage mode biquadratic filter three inputs three outputs using four operational transconductance amplifiers one current conveyor two grounded capacitors proposed circuit realize second order low pass band pass high pass band stop pass filters appropriately connecting input output terminals natural frequency quality factor set orthogonally circuit components also natural frequency electronically controlled realizing filter responses component matching conditions required active passive sensitivities low input impedances high pspice simulation results given confirm presented theory
study presents model drivetrain integrated design light electric vehicle drivetrain front wheel single person battery powered tricycle consists battery inverter outer rotor permanent magnet synchronous motor pmsm connected wheel gearbox efficiency inverter motor gearbox analyzed new european driving cycle calculate losses efficiency pmsm power electronics inverter gearbox used analytical models provide fat less accurate result useful optimization purposes accurately predict efficiency pmsm finite element model used models validated test setups correspondingly good agreement measurements calculated results achieved parameter study performed investigate influence detailed component parameters outer rotor radius gear ratio number pole pairs stator slots average efficiency drivetrain
paper deals automatic decomposition experimental frequency response functions frf mechanical structures decomposition frf based green function representation free vibratory systems determination impulse dynamic subspace system matrix formulated poles calculated directly means corresponding eigenvectors contribution element impulse dynamic subspace determined sufficient decomposition corresponding frf carried presented dominant modal decomposition dmd method mode shapes modal participation vectors modal scaling factors identified using decomposed frf analytical example presented along experimental case studies taken machine tool industry elsevier ltd rights reserved
aimto date understanding development novel treatments mental illness hampered inadequate animal models instance unclear extent commonly used behavioural tests animals inform mental affective aspects schizophrenia methodsto link pathophysiological processes animal model clinical findings utilized recently developed mouse model detailed investigations cortical neuronal engagement pre attentive processing auditory information two back translational auditory paradigms also investigate compromised putative fast spiking interneurone fsi function restored pharmacological intervention using channel opener chronic multi array electrodes primary auditory cortex used record single cell firing putative pyramidal fsi awake animals processing auditory sensory information resultswe find decreased amplitude response auditory stimuli reduced recruitment neurones fast steady state gamma oscillatory activity results resemble encephalography recordings patients schizophrenia furthermore probability interneurones fire low interspike intervals auditory stimulation reduced mice effect partially reversed channel modulator conclusionthis study offers insight consequences neuronal level carrying microdeletion furthermore points deficient functioning interneurones potential pathophysiological mechanism schizophrenia suggests therapeutic potential channel openers
research purpose extend adapt principles service oriented architecture combining patterns oriented design model driven engineering approaches analyzed existing approach developing multi platform multi devices systems studied four different approaches development responsive web design progressive enhancement based browser device feature detection markup languages based approaches service oriented architecture user interfaces summarized advantages weaknesses result analysis showed perspectives service oriented architecture approach multi device user interfaces research results allowed applying validating proposed extended service oriented architecture multi device user interfaces one problems addressed ongoing research large amount combinations possible implementations user interfaces different types devices platforms operating systems style interaction summarized advantages weaknesses result analysis showed perspectives service oriented architecture approach multi device user interfaces novelty solution problem new approach design visualizing layer distributed applications applied new service oriented architecture pattern proposed composing user interfaces services allowed delivering correct user interfaces regardless operation systems types devices according results designed developed pattern used ability service oriented architecture composition existed services new services
study authors find people satisfied service experience choose participate provider voluntary green program recycling effect mediated warm glow participation downside however mechanism decreases satisfaction among people choose participate study analysis data powerguest satisfaction index suggests incentivizing program compensating program participants paradoxically increases satisfaction participate decreases satisfaction among studies explore manipulating incentive characteristics might enable managers maximize satisfaction groups study indicates compared incentive benefiting incentive increases warm glow satisfaction green program participants decreases among nonparticipants study however suggests mixed incentive bundles providing self benefiting benefiting options maximize warm glow satisfaction groups ideal outcome managers
objectives community pharmacies united kingdom provide sexual reproductive health srh services emergency contraception although scope provision additional services conducted pilot study pharmacy based interventions initiating effective contraception determining views participating women pharmacists aimed identify barriers facilitators providing interventions pharmacies routinely study design pilot study women presenting levonorgestrel community pharmacies provided either standard care one two interventions one packet progestogen pills pops invitation present empty packet local family planning clinic contraception sample women participating asked undergo interview operational difficulties research community pharmacy also documented research team methods semi structured interviews conducted women four arm pilot study using standardised topic guide pre post study interviews conducted pharmacists involved results women welcomed interventions indicating benefit different options available also identified possible advantages disadvantages intervention pharmacists positive involvement study methodological problems included difficulty retention participating pharmacists slow recruitment failure accurately complete study paperwork conclusions women welcomed interventions offered pharmacists viewed participation study positively problems encountered provide valuable feedback inform development larger scale studies interventions royal society public health published elsevier ltd rights reserved
paper focus global self consistent hierarchical high resolution geography gshhg database registration remote sensing images taken geostationary meteorological satellites accuracy feature matching key component improve propose neighborhood geometry based feature matching scheme includes three steps neighborhood coding verification fitting neighborhood coding represents landmarks gshhg descriptive bit matrix quantifies remote sensing images probability based edge map binary geometry based edge map result gradient arid geometry similarity local features remote sensing image gshhg measured neighborhood verification encode spatial relationship among local features neighbor discover outliers neighborhood fitting fits shorelines gshhg landmarks registered neighborhood verification improve recall experimental results pairs newly annotated images show proposed method competitive several prior arts respect matching accuracy method significantly efficient others
concepts expressed social role terms artist scientist unique seem allow two independent criteria categorization one inherently normative knobe prasada newman study presents tests account content structure normative dimension dual character concepts experiment suggests normative dimension social role concept represents commitment fulfill idealized basic function associated role background information affect basic function associated social role however experiment indicates normative dimension always represents relevant commitment end argue social role concepts represent commitments basic functions information crucial predict future social roles role dependent behavior others
deregulated electricity markets independent system operator iso oversees power system manages supply demand balancing process typical day iso announces electricity demand forecast next day gives participants option prepare offers meet demand order reliable power system successful market operation crucial estimate electricity demand accurately paper develop hourly demand forecasting method annual weekly daily horizons using linear model takes account harmonics variations modulation diurnal periodic variations seasonal variations electricity demand exhibits cyclic behavior different seasonal characteristics model based solely sinusoidal variations predicts hourly variations without using climatic econometric information method applied turkish power market data period predicts demand daily weekly horizons within error margin mean absolute percentage error mape norm also discuss week day weekend holiday consumption profiles infer proportion industrial domestic electricity consumption elsevier ltd rights reserved
electric circuits transient elements good examples systems non steady irreversible processes occur way steady state energy converter use formal construction first order irreversible thermodynamic describe energetics circuits case propose isothermal model two meshes transient passive elements besides containing two voltage sources functions time non steady energy converter model kirchhoff equations write circuit phenomenological equations apply integral transformation linearize dynamic equations rewrite algebraic form frequency space however symmetry steady states appears cross effects thus study energetic performance converter model means two parameters force ratio coupling degree furthermore possible obtain characteristic functions dissipation function power output efficiency etc allow establish simple optimal operation regime energy converter example obtain converter behavior maximum efficient power regime
changes cognitive control timing implicated adhd involved building monitoring expectations environment altering behavior expectations violated adhd problems expectations future events high face validity would associated behavior inappropriate given certain context similar symptoms disorder fmri study used timing manipulated nogo task assess brain activity related expectations cognitive control timing events would occur hypothesized problems building expectations environment general trans diagnostic characteristic children hyperactive impulsive inattentive symptoms address included children asd symptoms adhd addition children adhd typically developing children found group differences brain activity related expectations timing events occur cognitive control specifically found timing related hypo activity part unique children primary diagnosis adhd left pallidum part shared children similar levels adhd symptoms primary diagnosis asd left subthalamic nucleus moreover found poorer task performance related timing children asd symptoms adhd ultimately neurobiological changes children adhd symptoms may relate failure build monitor expectations thereby hinder efficiency interaction environment
aim present study investigate possible pathogenesis osteosarcoma using bioinformatics analysis examine gene gene interactions total three datasets associated osteosarcoma downloaded gene expression omnibus differentially expressed genes degs identified using significance analysis microarrays method subjected human protein reference database identify protein protein interaction ppi pairs construct ppi network degs subsequent multilevel community analysis applied mine modules network followed screening differential expression module using globalancova package genes differential expression modules verified valid datasets verified genes underwent functional pathway enrichment analysis total degs selected construct ppi network included osteosarcoma specific interaction pairs normal specific pairs tumor protein mitogen activated protein kinase mapk estrogen receptor esr identified important osteosarcoma associated genes highest levels topological properties neurogenic locus notch homolog protein notch caspase casp identified osteosarcoma specific interaction pairs among mined modules three identified differential expression modules verified two datasets genes modules predominantly enriched fgfr mapk notch signaling pathways therefore mapk esr notch casp may important development osteosarcoma provides valuable clues investigate pathogenesis osteosarcoma using three differential expression modules
normative technical documents germany united kingdom portugal recommend use detailed methods size storage tanks rainwater harvesting systems methods based daily simulations system operation using daily rainfall data non potable demand however scarce information provided documents regarding appropriate criteria obtain rainwater storage tank making daily simulations study six different calculation methods described analyzed including simplified procedures detailed approaches different criteria apply methods two cases rainwater harvesting systems used dwelling public building results show methods based maximum rainwater use efficiency criteria result large storage volumes long payback periods appears amongst analyzed criterions appropriate size rainwater harvesting system daily simulation efficiency criteria best ratio economical savings installation cost also concluded rippl method efficiency criteria lead similar storage volumes elsevier rights reserved
background thalidomide effective inducing maintaining clinical remission children adolescents refractory crohn disease however little known efficacy safety thalidomide adult patients methods conducted prospective open label cohort study january april total adult patients active dependent resistant intolerant corticosteroids immunomodulators biologics received thalidomide daily primary outcome clinical remission evaluated week endoscopic assessment performed week defined endoscopic response decrease crohn disease endoscopic index severity cdeis score points baseline cdeis complete endoscopic remission cdeis score mucosal healing ulceration results total adults active enrolled clinical remission rate week week increased week week patients included intention treat analysis altogether patients consented underwent ileocolonoscopy week rate endoscopic response complete endoscopic remission ulceration achieved patients adverse events occurred patients necessitated therapy discontinuation patients conclusions low dose thalidomide effective tolerated inducing maintaining clinical remission adult patients active optimal time frame thalidomide induce clinical remission may longer previously appreciated probably optimal weeks could reasonably achievable thalidomide
purpose review highlight recent studies identifying novel regulatory molecules mechanisms plasma lipid metabolism recent findings two novel regulatory mechanisms ldl receptor ldlr intracellular trafficking described commd ccdc ccdc wiskott aldrich syndrome protein scar homologue complexes found involved ldlr endosomal sorting recycling whereas grp shown protect ldlr early degradation within hepatocyte secretory pathway additionally transcription factors phd bmal identified regulate ldl levels mice modulating cholesterol excretion important advances reported relevance two genome wide association studies hits reassessment galnt showed contrast previous reports loss galnt reduces hdl cholesterol humans mammalian species phospholipid transfer protein identified additional target galnt tetratricopeptide repeat domain protein found promote ubiquitination degradation liver receptor deficiency increased hdl cholesterol cholesterol removal also inhibiting lipogenesis mice summary unraveling mechanisms new factors modulate plasma lipid levels keep providing interesting opportunities rationally design novel therapies treat cardiovascular disease also metabolic disorders
judgment namibia supreme court government republic namibia others set important precedent informed consent case involving coercive sterilisation hiv positive women article analyses reasoning factual narratives judgment applying neil manson onora neill approach informed consent communicative process done effort understand practical import judgment particular context resource constrained public healthcare facilities many women southern africa access reproductive healthcare judgment affirms certain established tenets informed consent surgical procedures aspects reasoning context demand particularised applications means patient capacity informed appropriately accommodate disruptive role power dynamics communicative process
aim patients gynecologic cancer frequently experience bone loss due cancer treatments including bilateral oophorectomy chemotherapy radiotherapy study evaluated treatment associated changes bone mineral density bmd women gynecologic cancer compared changes among patients different types gynecologic cancer methods bmd lumbar spine femur retrospectively analyzed using dual energy ray absorptiometry women underwent treatment gynecological cancers women without gynecologic cancers cohort included women cervical cancer underwent surgery followed adjuvant chemotherapy radiation therapy endometrial cancer underwent surgery followed adjuvant radiation therapy ovarian cancer underwent bilateral oophorectomy followed adjuvant platinum based chemotherapy lumbar spine femoral neck bmd assessed baseline months treatment areal bmd expressed grams mineral scanned compared young healthy women score results demographic characteristics pretreatment bmds including scores differ among cancer types adjustment factors affect score cancer type affected change score months treatment adjustment pretreatment age parity bmi score score months treatment significantly lower groups conclusions women treated gynecological cancer particularly undergo bilateral oophorectomy followed adjuvant radiation therapy chemotherapy managed timely manner prevent minimize bone loss
sleep fundamental biological process crucial survival health humans many circumstances like physiological mental disorders environment lifestyle may affect healthy sleep date different sleep disorders internationally recognized cover broad field medical areas analysis human sleep typically based multidimensional biosignal recordings called polysomnographies psg therefore research often includes digital signal processing clinical sleep research inherent multidisciplinary field inter institutional interdisciplinary collaborations required address complexity sleep regulation disturbance date collaborative sleep research poorly supported systems particular management processing psgs challenging large variety psg devices data formats measurement procedures quality variations impedes consistent biosignal data processing manuscript introduce virtual research platform supporting inter institutional data sharing processing infrastructure based xnat free open source neuroimaging research platform loosely coupled service oriented architecture scalable virtualization back end system capable local pseudonymization biosignal data mapping standardized set parameters automatic quality assessment terms quality measures derived manual scoring sleep associated events american academy sleep medicine aasm facto standard diagnostic biosignal analysis sleep medicine elsevier rights reserved
big data new buzz word industry data exceeds processing analytic capacity conventional database systems within time necessary make useful multiple data stores abundant formats billions rows data hundreds millions data combinations urgent need making best possible decisions challenge big solution bigger big data comes new advances computing technology together high performance analytics simpler faster processing relevant data enable timely accurate insights using data mining predictive analytics text mining forecasting optimization complex data continuously drive innovation make best possible decisions big data provides solutions complex business problems like analyzing larger volumes data previously possible drive precise answers analyzing data motion capture opportunities previously lost poses bigger challenges testing scenarios testing highly volatile data often unstructured generated myriad sources web logs radio frequency rfid sensors embedded devices gps systems etc mostly clustered data accuracy high availability security requires specialization one challenging things tester keep pace changing dynamics industry aspects testing tester need know technical details behind scene however testing big data technology different tester needs strong testing fundamentals also equally aware minute details architecture database designs analyze several performance bottlenecks issues like example quoted memory databases tester would need know operating systems allocate allocate memory understand much memory used given time concluding data analytics industry evolves would see testing services getting closely aligned database engineering industry would need skilled testing professional domain grab new opportunities
purpose study discusses process constructing prototype pedagogical model working youth socially vulnerable backgrounds participants settings six month activist research project conducted soccer program socially vulnerable area brazil study included youths coaches pedagogic coordinator social worker expert student centered pedagogy inquiry based activism assisted debriefer helping progressive data analysis planning work sessions data collection analysis multiple sources data collected including field journal observation audio records youth work sessions coaches work sessions combined coaches youth work sessions meetings researcher expert findings process construction prototype pedagogical model divided three phases first phase involved youth coaches identifying barriers sport opportunities community second phase youth coaches researchers imagined alternative possibilities barriers identified final phase worked collaboratively create realistic opportunities youth begin negotiate barriers identified phase coaches youth designed action plan implement involving leadership program aimed addressing youths needs sport program five critical elements prototype pedagogical model created first two processes four learning aspirations emerged last phase project implications suggest activist approach creating pedagogical model sport working youth socially vulnerable backgrounds beneficial creating opportunities youth learn name critique negotiate barriers engagement sport order create empowering possibilities
text gives brief survey history fertility control serbia century present special attention given mid century period currently still prevalent model fertility control constituted serbia model marked combination behavioral methods abortion backup method author scrutinizes structural ideological features different levels social organization framed model family planning examines advantages medical contraception users perspective finally text discusses ambivalent status abortion society time rather widespread normalized method birth control stigmatized
mgo alo composite samples prepared alumina fused corundum sintered alumina high purity sintered magnesia aluminum powder creep test carried degrees studied results show creep rate sample without aluminum addition decreases gradually creep properties mgo alo composite material improved aluminum powder addition sample demonstrating increase creep rate physical properties samples enhanced aluminum powder addition well mechanism improvement sample analyzed different characterization methods kinetics calculations results indicates mgalo spinel phases formed creep test acting reinforcing phases therefore enhance creep performance samples published elsevier masson sas
developing drilling fluids low solid content preferred better solid control easier fluid maintenance faster penetration rate improved hydraulics oil natural gas exploration work low solid drilling fluids prepared replacing certain amount bentonite traditional fluids small amount cellulose nanoparticles cnps including cellulose nanocrystals cncs cellulose nanofibers cnfs aiming improve cost efficiency eco friendliness safety fluids rheological filtration properties fluids investigated compared traditional fluids without cnps results indicated low solid fluids exhibited obvious shear thinning behavior morphology cnps played essential role modifying fluid properties fluids smaller cncs lower viscosity yield point gel strength formed filter cakes larger porosity lower permeability comparison fluids larger longer cnfs differences attributed distinct cnc cnf morphologies interactions bentonite study helps promote applications biodegradable renewable additives well service fluids oil natural gas exploitation production elsevier rights reserved
drawing upon components social role theory postcolonial theory study examined role bollywood diaspora films formation renegotiation identity among non resident indian women manifested dress specifically interested creation new hybrid indian identity young women diaspora women able move seamlessly two worlds looking role bollywood reconciles traditional indian values progress postcolonial india
protein coupled receptor exciting promising target treatment type diabetes mellitus study three dimensional quantitative structure activity relationships comparative molecular field analysis comparative molecular field analysis region focusing carried novel series protein coupled receptor agonists quality pharmacophore model built hip hop algorithm best pharmacophore model indicated feature hydrogen bond acceptor hydrophobic existed around active compounds quality pharmacophore model satisfactory utilized search zinc database virtual screening task obtained compounds subjected lipinski filter first docked gold algorithm discover potent hits energy difference highest occupied molecular orbital lowest unoccupied molecular orbital gap implies high reactivity active molecule active site protein addition molecular electrostatic potential energy density functional theory level confirms results molecular docking silico absorption distribution metabolism excretion toxicity risk assessment analysis carried seven hits highest gold score fitness six new hits virtual screening diverse structures reported new scaffold candidates protein coupled receptor agonists
based second quarter construction beijing fourth quarter gdp quarterly data concentrations emissions beijing beijing agricultural output output value gross output value beijing food beverage industry control variable use var models eviews measurement software building construction industry development beijing relationship concentration emissions model study building industry relationship results showed growth gross output value construction concentration emissions beijing certain adverse effects finally construction beijing construction industry development emissions suppression lines put forward policy energy saving green building
wastewater contains significant quantities thermal energy consequently heat recovery sewer systems provide urban areas additional source renewable energy heating buildings however certain treatment processes wastewater treatment plant temperature sensitive water protection perspective therefore imperative heat recovery sewer systems negatively affect performance wastewater treatment regard practical implication question arises find locations best suitable wastewater heat recovery sewer systems hereby suitability characterised meeting energy supply water pollution control requirements article introduces methodological framework procedure evaluate suitability potential heat recovery site integrating perspectives framework incorporates decision support criteria planning principles energy planners water authorities application case study proved practicability procedure well criteria principles addition also delivered comprehensive information spatial temporal wastewater temperature development regarded sewer system elsevier rights reserved
objectives compare effects week treatment pueraria mirifica gel conjugated estrogen cream vaginal maturation index vaginal symptom score vaginal health assessment score vaginal flora postmenopausal women methods prospective noninferiority randomized controlled study postmenopausal women least one vulvovaginal symptom dryness soreness irritation dyspareunia discharge recruited participants randomly assigned two groups treatment either gel conjugated estrogen cream cee treatment regimen consisted application product intravaginally daily weeks decreased three times per week weeks vaginal maturation index vaginal symptoms score vaginal health assessment score evaluated beginning study weeks weeks treatment cee results vaginal maturation index increased significantly treatment groups week cee groups respectively significantly higher effect however observed cee group vaginal symptom scores decreased significantly treatment groups cee groups respectively conclusions use week treatment regimen pueraria mirifica gel shown efficacious safe treatment vulvovaginal atrophy conjugated estrogen cream found effective compared pueraria mirifica gel improving signs vaginal atrophy restoring vaginal epithelium weeks
till last decade unthinkable skin care would category consumers would like spend india strong economic performance youthful demographic structure ensuring great future cosmetic industry marketers retailers need successful bring innovation price products efficiently intelligently new product innovation defined degree individual adopts innovations relatively earlier members social system diffusion refers process innovation communicated certain channels time among members social system rogers celebrities became vocal grooming habits sharing self grooming details television advertising media led spurge sale fairness creams surprising leading cosmetic manufacturers introducing skin care lines specifically tailored males present study attempts build possible associations based previous researches socio demographics perceived innovation characteristics consumer innovativeness new product adoption behavior owing product innovations skin care range special reference fairness creams males
purpose review cardiovascular disease cvd increasingly afflicts people living hiv plwh contemporary era antiretroviral therapy art coronary artery disease cad widely studied cardiovascular problem plwh however less known clinically relevant subtypes cvd heart failure cerebrovascular disease sudden cardiac death pericardial diseases pulmonary hypertension paper reviews evidence subtypes cvd emerging issues post art era recent findings recent studies shown plwh higher risk well subclinical impairment left ventricular mechanics systolic diastolic dysfunction myocardial abnormalities fibrosis steatosis underlying mechanisms however well understood studies also shown higher rates atrial fibrillation sudden cardiac death plwh ischemic stroke common stroke type post art era underlying mechanisms like identified cad chronic inflammation associated vasculopathy studies great vessels carotid artery aorta peripheral arterial disease show heterogeneous results small subclinical pericardial effusions common plwh post art era pulmonary hypertension continues underdiagnosed potentially fatal complication hiv infection summary plwh remain higher risk types cvd including heart failure stroke arrhythmias post art era chronic inflammation may play important role increased risk studies needed elucidate extent non coronary cvd plwh underlying mechanisms
one biggest countries world rank construction industry asia indonesia far behind compared neighboring countries terms green building movement confirmed fact buildings indonesia earned greenship certification issued green building council indonesia present therefore research conducted identify barriers green building movement indonesia building occupants point view data presented paper mainly derived interviews responses questionnaire distributed randomly building occupants experiences either conventional green buildings around jakarta bandung based findings respondents identified barriers burdensome implementation lack supported atmospheres resistance change inadequate knowledge information negligence high cost green building options insufficient supervision lack awareness low availability green products market lack building management role work concludes recommendations performance improvement strategies analyzed swot method authors published elsevier ltd
statistical models involve two part mixture distribution applicable variety situations frequently two parts model binary response variable model outcome variable conditioned binary response two common examples zero inflated hurdle models count data two part models semicontinuous data recently particular interest use models analysis repeated measures outcome variable time aim review consider motivations use models context highlight central issues arise use examine two part models semicontinuous zero heavy count data also consider models count data two part random effects distribution
human mandible said arise desmal ossification however true entire body mandible meckel cartilage prone ossification least anterior part canine incisor region also within coronoid condylar processes cartilaginous cores eventually undergo ossification furthermore number additional single cartilaginous islets arising fetuses crl located predominantly within bone buccal sides brims dental compartments mostly gussets dental primordia become wedge shaped elongated diameter around also found older stages crl oldest specimen used study report intended visualize single cartilaginous islets histologically reconstructions stereoscopic images although singular cartilaginous tissue within mandible may remains decaying meckel cartilage reconstructions clearly show aforementioned cartilaginous islets independent thereof derived separate locations within mandibular bone reasons lead cartilaginous formations remained unknown far elsevier gmbh rights reserved
children youth journey school represents significant opportunity increase daily levels physical activity using non motorized modes travel walking biking studies active school travel demonstrated likelihood child walk bike significantly influenced distance must travel home school turn influenced built environment characteristics configuration local road network study examines shortcuts facilitate active school travel decreasing distance children must travel get school geographic information system used compare shortest route distances along road networks without shortcuts elementary school zones london ontario canada provide evidence effectiveness shortcuts facilitate active school travel study contributes two key findings shortcuts greater impact areas low street connectivity low population density children living farther school likely benefit shortcuts findings suggest planners consider location maintenance shortcuts school neighbourhoods order promote increased physical activity health well among students
background ability recognize emotional expression essential social interactions adapting environment quality life emotion recognition impaired people alzheimer disease thus rehabilitation skills potential elicit significant benefits objective study sought establish whether emotion recognition capacity could rehabilitated people methods thirty six participants assigned one three conditions experimental group received sessions rehabilitation emotion recognition sessions cognitive stimulation therapy cst control group received sessions cst treatment usual group tau results positive treatment effect favoring found participants better able correctly identify emotions made fewer errors commission greater precision processing faster processing speed specifically better able identify sadness disgust neutral expression quicker processing speed disgust gains maintained one month follow exception processing speed surprise improved conclusion capacity recognize facial expressions emotions improved specific rehabilitation people gains still present one month follow findings implications design rehabilitation techniques people may lead improved quality life social interactions population
zero difference balanced zdb functions many applications coding theory cryptography communications engineering recently authors generalized definition zdb functions zdb functions paper based cyclotornic cosets two classes zdb functions obtained several new classes zdb functions constructed furthermore frequency hopping sequences obtained directly functions
paper presents novel integrated platform energy monitoring management savings context smart university building namely proposed smart international hellenic university ihu platform integrates intelligent rule based agent enforces savings variety applications offers user interaction system means monitoring management application layer built common web service middleware incorporating semantic interoperability monitoring applications visualize raw aggregated sensor readings building energy disaggregation environmental measurements data center efficiency extensive monitoring capabilities allow users take immediate action devise policies towards energy savings policies autonomously enforced intelligent hybrid agent capable deliberative long term reactive immediate actions agent also integrated openadr standard receiving provider instructions future smart grids pilot deployment agent expert formulated policies premises managed reduce total daily consumption typical university office approximately
study examined associations among posttraumatic stress disorder ptsd symptom severity antisocial personality disorder aspd diagnosis intimate partner violence ipv sample substance abuse treatment seeking men women positive trauma histories sex examined moderator aspd diagnosis significantly predicted verbal physical aggression sex moderated association aspd diagnosis physical violence ptsd symptom severity significantly predicted engaging verbal physical aggression overall results suggest aspd diagnosis may important risk factor engaging ipv among women seeking treatment substance use disorder
electrorheological elastomer ere member smart material family many efforts made develop high performance eres preparing active electrorheological particles work excellent particles named spherical tetragonal batio successfully synthesized hydrothermal method different conditions using center dot amorphous tio original materials analysis structure morphology synthesized particles raman xrd sem techniques indicates additives play crucial role determining surface morphology particles additionally discovered spherical tetragonal batio particles different surface morphology possess different tetragonality surface hydrophilicity dielectric property thus exhibit distinct electric field response response batio particles electric field order daisy shaped walnut shaped sphere particles experiments reveal high tetragonality fine dielectric performance super surface hydrophilicity batio particles major power boosting electric field response elsevier rights reserved
demyelination axonal degeneration caused multiple sclerosis exist white matter lesion area magnetic resonance spectroscopy mrs could provide unique insight metabolic changes normal appearing white matter nawm evaluate subtle axonal degeneration delineate spatial distribution metabolite abnormalities nawm patients total clinically definite relapsing remitting rrms patients healthy controls enrolled study magnetic resonance spectroscopic imaging mrsi performed tesla used measure metabolite concentrations frontal parietal occipital nawm ratios acetyl aspartate naa choline cho creatine cho naa calculated voxel patients showed decreased naa increased cho naa ratios nawm compared healthy controls parietal nawm extent naa decrease significantly higher frontal parietal occipital nawm decreased naa nawm would provide useful metabolic information evaluation disease progression high extent naa decrease parietal nawm helps improve accuracy prediction
background suicide rates higher veterans compared general population perhaps due trauma exposure previous literature highlights depressive symptoms anger contributors suicide risk ptsd symptoms may indirectly affect suicide risk increasing severity cognitive emotional factors method sample community dwelling veterans completed online surveys including ptsd checklist military version suicidal behaviors questionnaire revised multidimensional health profilepsychosocial functioning differential emotions scale bivariate serial mediation analyses conducted test direct indirect effects ptsd symptoms suicide risk results bivariate analyses ptsd symptoms depression anger internal hostility positively related suicide risk serial mediation analyses significant total effect ptsd symptoms suicide risk models ptsd symptoms also indirectly related suicidal behavior via depression internal hostility via internal hostility alone anger significant mediator limitation cross sectional sample predominantly white male prospective studies diverse veterans needed discussion findings may implications veteran suicide prevention effects ptsd depression anger particularly internal hostility related suicide risk suggesting potential mechanism action ptsd suicide linkage multi faceted therapeutic approach targeting depression internal hostility via cognitive behavioral techniques behavioral activation cognitive restructuring may reduce suicide risk veterans experienced trauma
objectives prospectively evaluate pregnancy desirability stated intentions pregnancy occur among emergency contraception users explore differences women selecting copper intrauterine device iud oral levonorgestrel lng regarding hypothetical pregnancy plans actual pregnancy actions subsequent unintended pregnancies study design prospective observational trial women received iud oral lng without cost barriers baseline participants completed visual analogue scale measuring pregnancy desirability anchors trying hard get pregnant trying hard get pregnant self reported plans abortion adoption parenting unsure pregnancy test come back positive pregnancies tracked months actions regarding unintended pregnancies compared method groups results enrolled women chose iud oral lng pregnancy desirability baseline low difference groups iud group lng group fifty four women experienced unintended pregnancies pregnancy plans baseline changed women became pregnant groups differ hypothetical pregnancy intention agreement hypothetical pregnancy intention actual pregnancy action conclusions women presenting state high desire prevent pregnancy regardless method selected considering hypothetical pregnancy half women plan would respond situation confronting actual unintended pregnancy half altered plan clinical trial registration number clinicaltrials gov identifier nct
paper gives overview important german language diagnostic instruments suitable use schizophrenia procedures implemented different phases disorder depending nature questions involved addition clinical interviews diagnostic classification self rating observer rating scales psychopathological symptoms presented procedures described take account psychotic phenomena delusions hallucinations well quality life insight social consequences disorder
study aimed optimizing horizontal subsurface flow constructed wetlands cws improve hydraulic performance pollutant removal efficiency groundwater modeling package modflow used optimize three design parameters length width ratio inlet outlet length ratio substrate size configuration using optimized parameters three pilot scale cws built treat actual wastewater model validation used tracer test evaluate hydraulic performance investigated pollutant spatial distributions removal efficiencies conclude modflow suitable designing cws accurately predicting increasing hydraulic conductivity surface bottom layers could improve performance however effect vegetation decreased hydraulic conductivity surface layer considered improve simulation results multilayer substrate configuration increasing hydraulic conductivity surface bottom layers significantly increased pollutant removal compared monolayer configuration spatial variation pollutant transport degradation filling substrate showed multilayer configuration able increase use available space moderately reduced short circuiting dead zones thus multilayer cws higher experimental retention times effective volume fractions hydraulic efficiencies lower short circuiting compared monolayer cws operating similar conditions
improve practical education many japanese universities implementing project based learning pbl although previous study examined relationship educational effectiveness scatter personal characteristics relationship educational effectiveness combination personal characteristics team important optimize team composition pbl yet examined herein use five factor stress theory measure personal characteristics classify students enrolled pbl class waseda university four types leadership management tugboat anchor knowledge skills questionnaires used measure educational effectiveness results show educational effectiveness highest team consists management anchor types without leadership types results preliminary practical usefulness results limited experiment paper targeted one pbl course one university reason need collect data pbl course university
often employed analysis conventional engines mathematical models also applied engines torch ignition researched almost exclusively cfd experimentally objective work describe development application zero dimensional model compression power strokes torch ignited engine initial analysis used basis future models processes compression combustion expansion described mathematically applied existing prototype means computer code written matlab language conservation energy mass ideal gas law used determining gas temperature pressure mass flow rate within cylinder gas motion orifice modelled isentropic compressible flow thermodynamic properties mixture round weighted arithmetic mean data component computed polynomial functions temperature combustion modelled wiebe function heat transfer cylinder walls estimated annand correlations results revealed behaviour pressure temperature jet velocity energy transfer thermodynamic properties among variables influenced others elsevier ltd rights reserved
objective extracellular deposition beta amyloid beta peptide main finding pathophysiology alzheimer disease leads oxidative damage apoptosis neurons melissa officinalis officinalis medicinal plant lamiaceae family neuroprotective activity present study investigated protective effect acidic fraction officinalis beta induced oxidative stress apoptosis cultured cerebellar granule neurons cgn additionally investigated possible role nicotinic receptor materials methods study vitro experimental study performed mice cultured cgns cgns pre incubated different concentrations acidic fraction officinalis hours followed incubation beta additional hours cgns also pre incubated acidic fraction officinalis mecamylamin followed incubation beta used dimethylthiazol diphenyltetrazolium bromide mtt assay measure cell viability acetylcholinesterase ache activity reactive oxygen species ros production lipidperoxidation caspase activity measured incubation hochst annexin fluorescein isothiocyanate fitc propidium iodide staining performed detect apoptotic cells results acidic fraction could protect cgns beta induced cytotoxicity mecamylamine abolish protective effect acidic fraction ache activity ros production lipid peroxidation caspase activity increased beta incubation preincubation acidic fraction officinalis ameliorated factors decreased number apoptotic cells conclusion results indicated protective effect acidic fraction officinalis mediated nicotinic receptors fraction could protect cgns antioxidant anti apoptotic activities
micro blog important part network media become important access information netizens hot topics immeasurable impact public opinion formation dissemination also potential security risks absolutely underestimated collecting relevant data micro blog provide data base public opinion analysis study social topic detection system based micro blog mainly centered key technologies information capture chinese handling micro blog study invokes api sina micro blog three kinds capture strategy uses rmm reverse maximum matching algorithm capture information micro blog using classification self build public opinion information classification micro blog structured storage last study finishes research implement system based micro blog system realized hot topics timely capture collection classification storage retrieval lay foundation public opinion analysis
examined hypothesis pain increases negative person perception irrelevant others medical laboratory settings three studies patients perceived nurse negative injection received nurse produced pain pilot study patients rated neutral faces negative receiving injection study participants performed painful cold pressor task rated neutral faces negative control group effect appeared low perceived social support study findings suggest one experience physical pain may metaphorically transferred perceptions completely irrelevant others inducing negative interpersonal perception perceived social support ameliorate negative effect
article provides estimate aggregate thickness required unpaved roads resting phi soil conventional practice design unpaved roads mostly considers subgrade layer purely cohesive soft marshy lands however huge bulk indian sub urban rural unpaved roads rest phi soil subgrade soil whose strength characteristics contributed cohesion angle internal friction phi imperative cohesion considered sole strength criterion provide lower bearing resistance hence overestimate aggregate thickness required eventually lead undesirable increase overall project cost regard article reports result attempt made identify diminution required aggregate thickness unpaved road strength characteristics subgrade soil taken account utility single geotextile layer beneath aggregate also investigated towards reduction required aggregate thickness incorporating bearing capacity estimation phi soil necessary expressions developed estimating required aggregate thickness function axle load tire inflation pressure cohesion angle internal friction subgrade soil angle internal friction load distribution angle aggregate extended ranges aforementioned parameters suitable indian context considered effect absence presence geotextiles reported efficacy geotextiles elucidated terms degree improvement represented reduction aggregate thickness encouraging improvement level observed many instances authors published elsevier ltd
symbolic macromodel slew settling characterization fully differential switched capacitor integrators proposed work model intended fast behavioral simulation data converters time domain main advantages proposed model created automatically without need running transient simulation fully composed circuit elements simulated spice matlab created symbolic form adjustment transistor level circuit directly reflected macromodel without need remodeling proposed modeling methodology validated applying integrators implemented two different operational amplifiers step response waveforms integrator model good agreement transistor level simulation results speedup
investigation paper higher order nonlinear schrodinger equation describe propagation ultrashort pulse inhomogeneous optical fiber lax pair conservation laws constructed integrability equation verified nonautonomous breathers rogue waves equation derived based darboux transformation generalized respectively influence group velocity dispersion third forth order dispersion gain loss coefficient propagation interaction nonautonomous breathers rogue waves also discussed specifically exist two types nonautonomous breathers expressions quasi periods two types nonautonomous breathers given effects coefficients quasi periods also discussed gain loss coefficient affects background nonautonomous breather third order dispersion influence trajectory nonautonomous breather group velocity dispersion affects range nonautonomous rogue wave addition group velocity dispersion also produces skew angle skew angle rotates clockwise direction increase group velocity dispersion forth order dispersion coefficient taken linear function distance structure rogue wave pair formed separation relative locations two constituents rogue wave pair affected coefficients linear function elsevier ltd rights reserved
background alstonia scholaris apocynaceae important herbal medicine widely used treat respiratory tract diseases cough asthma phlegm chronic obstructive pulmonary disease purpose evaluate pharmacological effect alkaloids scholaris ovalbumin induced airways allergic inflammatory model explore whether dosing frequency related pharmacokinetics study design oral administration total alkaloids pharmacokinetic study investigated addition anti allergic studies carried ovalbumin sensitized airways allergic inflammatory model mice methods pharmacokinetics total alkaloids investigated rat plasma fully validated method ovalbumin ova sensitized airways allergic inflammatory model established mice intra gastrically administrated times day based pharmacokinetic behavior single treatment regimen dexamethasone used positive control corticosteroid drugs cellular infiltration assessed broncho alveolar lavage fluid balf expressions interleukin interleukin balf determined levels immunoglobulin ige eotaxin serum measured superoxide dismutase sod activities well malondialdehyde mda content serum balf examined finally histopathological examination lung assessed staining results time course plasma concentration bioactive indole alkaloids fitted open two compartment model oral administration total alkaloids doses area curve maximum concentration values four major alkaloids increased dose dependently half life suggested short lasting pharmacological effect ovalbumin provoked airways allergic inflammatory model indicated pharmacological effect administration total alkaloids times day little better single dose daily percentage eosinophils balf reduced obviously pathological damage lung also attenuated also significant reduction promotion balf serum ige eotaxin expression also significantly decreased treated animals furthermore activity sod elevated remarkably lipid peroxidation product mda decreased administrated mice conclusion pharmacological effects administrated times day precedence single dose daily related prolonged retention time maintained plasma concentration moreover scholaricine vallesamine might responsible treatment allergic asthma mainly total alkaloids elsevier gmbh rights reserved
basal vacuolization renal tubular epithelial cells useful postmortem marker ketoacidosis investigate incidence relationship severity ketoacidosis autopsy cases elevated hydroxybutyrate mmol year period retrospectively reviewed sixty eight cases exhibited basal vacuolizations vitreous hydroxybutyrate mmol mean mmol cases vitreous hydroxybutyrate mmol mean mmol quantitative analysis revealed average fourfold elevation hydroxybutyrate cases basal vacuolizations compared without cases hydroxybutyrate concentrations mmol basal vacuolizations incidence increased concentrations mmol marked increase incidence observed concentrations mmol basal vacuoles invariably present concentrations mmol study demonstrates basal vacuolizations sensitive marker significant ketoacidosis reaffirms use indicator likely cases fatal ketoacidosis autopsy
crack cocaine abuse dependence severe public health problem sometimes crack cocaine smokers show behavioral changes symptoms similar observed severe mental disorders like schizophrenia although crackcocaine use easily detected smokers urine blood tests time cocaine biomarkers become untraceable addition schizophrenia diagnosis limited clinical interviews precise clinical tests mental disorder remain unknown employing metabolomics based nmr spectroscopy herein showed blood serum metabolites might used discrimination crackcocaine users schizophrenia patients groups two groups showed greatest differences around eleven keymetabolites moreover seven possible peripheral metabolites might enough differentiation crack cocaine users healthy controls results may contribute better understanding crack cocaine biochemical effects enable precise diagnosis crack cocaine biomarkers methylecgonidine ecgonidine absent urine blood crack cocaine users
process chain sheet metals casting produce components made semi finished products complex resulting mechanical properties produced material depend strongly evolution microstructure casting typical process chain consists hot rolling cold rolling annealing skin pass rolling sheet metal forming order represent microstructure evolution adequate way multiscale modeling concept applied process steps cold rolling annealing sheet metal forming integrated computational materials engineering icme concept strong microstructure evolution production semi finished products modeled using crystal plasticity representation cold rolling process cellular automaton incorporated model annealing procedure cases microstructure adequate unit cell considered sheet metal forming whole component simulated together interaction workpiece forming tools order solve technological problems like springback purpose classical macroscopic plasticity models applied connect different length scales modeling approaches scale transition basis numerical homogenization introduced determination mechanical properties like multi axial yield behavior information required virtually determine type macroscopic plasticity model material parameters plasticity model simulate sheet metal forming processes article different modeling approaches compared step step experimental investigations order prove predictability modeling technique
background ageing complex process due accumulation molecular damage time ageing biological reality dynamics beyond human control people aged years generally referred older population intrinsic ageing genetic chronological ageing extrinsic ageing environmental photo ageing contribute cutaneous ageing common skin disorders elderly xerosis pruritus dermatoheliosis seborrheic keratosis cherry angioma herpes zoster dermatophytosis cellulitis eczemas background propose study determine pattern cutaneous manifestations geriatric population attending tertiary care centre aim study pattern skin diseases geriatric age materials methods three hundred patients years age attending dermatology opd tertiary care hospital puducherry chosen study group study carried years detailed history taken general systemic cutaneous examination carried cutaneous mucosal lesions recorded relevant investigations included haemogram biochemical tests skin biopsy performed results total patients studied male female pruritus commonest complaint noted study xerosis commonest physiological change seen systemic hypertension commonest associated systemic illness lichen simplex chronicus commonest eczema fungal infection commonest infection bullous pemphigoid bullous disorder encountered study greying hair commonest hair change vertical ridging nails commonest physiological nail change seen study conclusion significant number geriatric population increased emphasis geriatric medicine inevitable present study helps providing greater understanding pattern geriatric dermatoses aids early diagnosis management
dynamic network visualization challenging research topic due visual computational complexity introduced extra time dimension existing solutions usually good overview presentation tasks interactive analysis large dynamic network introduce paper new approach considers dynamic network central focus node also known egocentric dynamic network major contribution novel visualization design greatly reduces visual complexity dynamic network without sacrificing topological temporal context central focus node design egocentric dynamic network presented single static view supporting rich analysis user interactions time network propose general framework visualization approach including data processing pipeline visualization algorithm design customized interaction methods finally demonstrate effectiveness approach egocentric dynamic network analysis tasks case studies controlled user experiment comparing three baseline dynamic network visualization methods
objective paper analyze potential benefits flywheel energy storage light rail networks primarily terms supply energy reduction present methods used method analysis based train movement electrical network load flow simulation results analysis indicate potential energy saving due introduction flywheel energy storage energy saving effects receptivity energy transfer one train another also considered additional benefits flywheel energy storage terms voltage drop improvements reduction peak substation power loading demonstrated test case scenario novel traction electrical network load flow algorithm using modified nodal analysis mna described detail allows intuitive representation network elements trains substations direct solution substation currents
given conflict conservative views gender roles motherhood economic political realities article analyzes conservative women organizations framed sarah palin michele bachmann bids national office advocates negotiate ideological beliefs gender roles motherhood interest electing republicans promoting women politics findings reveal frame transformation activists navigate seemingly incompatible values far shying away discussing conservative women roles mothers conservative women groups highlight palin bachmann maternal statuses argue willingness showcase families make different appealing kinds leaders also challenge feminist conceptualizations women interests exemplify importance conservative women participate politics
background one primary obstacles widespread adoption openehr methodology lack practical persistence solutions future proof electronic health record ehr systems described openehr specifications paper presents archetype relational mapping arm persistence solution archetype based ehr systems support healthcare delivery clinical environment methods first data requirements ehr systems analysed organized archetype friendly concepts clinical knowledge manager ckm queried matching archetypes necessary new archetypes developed reflect concepts encompassed existing archetypes next template designed archetype apply constraints related local ehr context finally set rules designed map archetypes data tables provide data persistence based relational database results comparison study conducted investigate differences among conventional database ehr system tertiary class hospital china generated arm database node path database five data retrieving tests designed based clinical workflow retrieve exams laboratory tests additionally two patient searching tests designed identify patients satisfy certain criteria arm database achieved better performance conventional database three five data retrieving tests less efficient remaining two tests time difference query executions conducted arm database conventional database less arm database approximately times efficient conventional database patient searching tests node path database requires far time two databases execute data retrieving patient searching tests conclusions arm approach capable generating relational databases using archetypes templates archetype based ehr systems thus successfully adapting changes data requirements arm performance similar conventionally designed ehr systems applied practical clinical environment system components arm greatly facilitate adoption openehr architecture within ehr systems
work focuses development software solution observation management industrial unit automation actual software solution designed tablets mobile phones running android operating system presented paradigms also applied mobile platforms operating systems custom software allows operator control manage devices remotely major focus observation operator actions expected critical situations solutions case study solved intuitively possible parameter adjustments may performed laymen simple user interface places fewer demands operator automatization units paper focused definition issue also introduces reader log device variants mainly reflects extensively creation low level network protocol bridge application issues one way link connections issues broader network connectivity internet tunnelling addressing resolved
species distribution modelling useful conservation rare endangered species freshwater mussel declines thinned species ranges producing spatially fragmented distributions across large areas spatial fragmentation combination complex life history heterogeneous environment makes predictive modelling difficult machine learning approach maximum entropy used model occurrences suitable habitat federally endangered dwarf wedgemussel alasmidonta heterodon maryland coastal plain catchments landscape scale predictors land cover land use soil characteristics geology flow characteristics climate used predict suitability individual stream segments heterodon best model contained variables three scales minimum elevation segment scale percentage tertiary deposits low intensity development woody wetlands sub catchment percentage low intensity development pasture hay agriculture average depth water table catchment despite small sample size owing rarity heterodon cross validated prediction accuracy predicted suitable segments occur catchments known contain heterodon provides opportunities new discoveries population restoration model predictions guide surveys toward streams best chance containing species alternatively away streams little chance containing heterodon developed reaches low predicted suitability heterodon coastal plain urban exurban sprawl continues modify stream ecosystems region underscoring need preserve existing populations discover protect new populations copyright john wiley sons ltd
introduction aim study evaluate effects consecutive night shifts cns shift length cognitive performance sleepiness materials methods study evaluated sleepiness performance control room operators cros working nights days days ndo cros working nights days nights days ndno shift patterns petrochemical complex last night shift swinging day shift assess cognitive performance back test continuous performance test simple reaction time test employed assess sleepiness karolinska sleepiness scale used results schedules indicated correct responses response times working memory reduced intentional errors sleepiness increased shift work cns significant impact reaction time commission errors conclusion main duty cros petrochemical plant checking hazardous processes require appropriate alertness cognitive performance result planning appropriate working hours suitable number cns rotating shift system contribution improving cro performance enhancing safety
purpose determine dose dependent effects testosterone administration cognition women low testosterone levels methods hysterectomized women without oophorectomy total testosterone free testosterone received standardized transdermal estradiol regimen week run period randomized receive weekly intramuscular injections placebo testosterone enanthate weeks total testosterone measured serum free testosterone levels measured equilibrium dialysis cognitive function evaluated using comprehensive battery standardized neuropsychological tests baseline weeks results women baseline end treatment cognitive function data constituted analytic sample five groups similar baseline mean treatment nadir total testosterone concentrations placebo groups respectively significant changes spatial ability verbal fluency verbal memory executive function observed treatment arm compared placebo even adjustment baseline cognitive function age education multiple regression analysis show significant relation changes testosterone concentrations change cognitive function scores conclusion short term testosterone administration wide range doses weeks women low testosterone levels neither associated improvements worsening cognitive function
ads injector five superconducting magnets cryomodule superconducting magnet contains solenoid magnet horizontal dipole corrector hdc vertical dipole corrector vdc six current leads required power electrical circuits room temperature liquid helium bath two leads carry current solenoid magnet four carry hdc vdc paper presents principle current lead optimization includes cooling methods choice material structure issues current lead integration
background purpose developed week balance training program older adults shown improve fall related concerns gait speed balance performance physical function hypothesized balance training would also contribute higher habitual physical activity levels improved health related quality life hrqol primary aim evaluate short long term effects balance training program objectively measured habitual older adults osteoporosis secondary aims assess effects balance training hrqol study whether effects associated changes hrqol gait speed balance performance fall related concerns physical function methods randomized controlled trial follow months including participants osteoporosis years compared balance training group control group primary outcome effect habitual measured steps day dichotomized less steps day physical activity assessed pedometers yamax accelerometers actigraph hrqol short form gait gaitrite walkway balance performance modified figure eight test one leg stance fall related concerns falls efficacy scale international physical function advanced lower extremity subscale questionnaire late life function disability instrument statistical methods used multivariate logistic regression logistic generalized estimating equation results sixty eight participants completed short term follow months participants completed long term follow months per protocol analysis showed odds ratio daily step count months confidence interval intervention group compared control group longitudinal analysis showed odds ratio daily step count months confidence interval intervention group compared control group mental component sum improved significantly baseline months intervention group physical component sum improved groups statistically significant differences found groups associations found changes covariates discussion conclusions short term evaluation showed balance training increased habitual community dwelling older adults osteoporosis significantly higher proportion participants intervention group reached level steps day important overall health effect associated improvements hrqol gait speed balance performance fall related concerns persist long term follow accomplish sustained change prolonged intervention support regarding habitual may required reinforcement personalized behavior change counseling prescription
purpose study conducted develop customized birth control program identify effects attitude subjective norm behavioral control intention behavior contraception among immigrant postpartum mothers methods experimental study vietnamese filipino cambodian married immigrant postpartum mothers recruited assigned experiment group control group customized birth control program provided experimental group weeks results experimental group showed significant increase score attitude subjective norm behavioral control intention behavior contraception conclusion findings study indicate customized postpartum birth control program systematic integrative intervention program composed customized health education counseling telephone monitoring able provide effective planning postpartum health promotion birth control behavior practice married immigrant women
advent agile software processing methods needs write programs software best quality shortest possible time unorthodox practices computer programming becoming common one practices pair programming characterized two programmers sharing computer collaborative programming purposes pair programming implies psychological social interaction participating programmers goal paper evaluation pair programming determine influence programmers personality problem difficulty efficiency pairs agent based system used simulate pair myers briggs type indicator mbti used measure personality member pairs paper presents suggests evaluates role personality formation utility pair
interest behind use component based software engineering divide information system subsystems less complexity reduction time faster development enhancing productivity software systems developed assembling components software units offer set services exposed interfaces indispensable role component based development component model defines components built assembled component intended provide specific services management combination communication system units manager component important complementary paradigm development software systems functionalities encapsulates must related consistent model presented paper proposes component called manager software component based viewpoint vision system user actor assembly base component system components
self compassion interventions may uniquely suited address body image distress bid change based strategies may limited utility cultural context highly values appearance current study evaluated version internet based self compassion training previously shown promising results limited high attrition intervention period reduced three weeks one week present study improve retention eighty undergraduate women endorsing body image concerns randomized either self compassion meditation training waitlist control group results suggest brief exposure basic tenets self compassion holds promise improving aspects self compassion bid attrition minimal compliance meditation practice instructions week low efforts needed improve engagement approach potential acceptable cost effective method reduce bid elsevier ltd rights reserved
irritable bowel syndrome ibs common condition affecting around population associated poorer psychological well quality life aim current study explore efficacy common sense model csm using structural equation modelling sem ibs cohort one hundred thirty one ibs patients males females mean age years participating ibsclinic org pre intervention assessment included measures included ibs severity irritable bowel syndrome severity scoring system coping patterns carver brief cope visceral sensitivity visceral sensitivity index illness perceptions brief illness perceptions questionnaire psychological distress depression anxiety stress scale quality life ibs quality life scale ibs qol using sem final model excellent fit identified cfi tli srmr consistent csm illness perceptions significantly directly influenced ibs severity beta illness perceptions turn directly influenced maladaptive coping beta visceral sensitivity beta maladaptive coping visceral sensitivity significantly associated psychological distress beta beta ibs qol beta beta based findings argue augment adverse impact ibs severity ibs qol psychological distress psychological interventions best target mediating psychological processes including illness beliefs visceral sensitivity maladaptive coping
novel surgical techniques require laparoscopic instruments intelligent micro manipulators rather simple manually operated scissors hydraulic drives high force power density low weight perfect candidates drive new laparoscopic instruments however use intelligent systems requires integration displacement measurement technology ensure controllability aim paper characterization miniaturization capacitive sensor integrated hydraulic drives order improve precision instrument positioning proposed sensor solution structurally integrated hydraulic drive using barrel rod coaxial cylindrical capacitor additional sensor needs integrated performance proposed solution examined using fea simulations mini miniaturized cylinder design simulation validated experimentally results good agreement results showed linear relationship capacitance displacement precision thus proving feasibility method
structural magnetic resonance imaging studies reported volume reductions several brain regions implicated social cognition emotion recognition juvenile antisocial populations however unclear whether structural abnormalities specifically related antisocial features cooccurring callous unemotional traits present study employed voxel based morphometry assess grey matter volume gmv grey matter concentration gmc large representative risk sample adolescents mean age characterized broad range trait conduct disorder symptom scores significant interaction symptom trait scores prediction gmv anterior insula significant positive association traits gmv youth low symptoms addition found significant unique positive association symptoms gmc amygdala unique negative associations traits gmc amygdala insula findings line accumulating evidence distinct associations symptoms traits amygdala insula gmc juvenile antisocial populations elsevier ireland ltd rights reserved
background women least prior occurrence premature birth often demographic medical risk factors modifiable however smoking cessation could targeted intervention woman history premature birth may able reduce future risk recurrence objective study aims assess trimester specific smoking patterns influence risk recurrent premature birth study design population based retrospective cohort study singleton nonanomalous live births ohio using vital statistics birth records analysis limited women least prior premature birth rates birth weeks compared among nonsmokers women smoked months prior pregnancy quit first quit second quit third trimester multivariate logistic regression analyses assessed association smoking cessation various time points pregnancy recurrent premature birth adjusting maternal race education medicaid enrollment marital status results analyzed outcomes women prior premature birth subsequently delivered weeks one third women prior premature birth smoked pregnancy smokers quit early first trimester quit second quit third trimester smoked throughout pregnancy rate recurrent premature birth nonsmokers high cohort smoking pregnancy cessation first second trimester significantly associated increase recurrent premature birth rates first trimester adjusted odds ratio confidence interval second trimester adjusted odds ratio confidence interval respectively however quitting late pregnancy third trimester associated high rate delivery weeks adjusted odds ratio confidence interval continued smoking throughout pregnancy also associated increased recurrent premature birth adjusted odds ratio confidence interval despite adjustment concomitant premature birth risk factors conclusion smoking cessation pregnancy relationship preterm birth studied extensively widely accepted smoking pregnancy increases preterm birth rates however study provides novel information quantifying risk recurrent preterm birth stratifies increased risk recurrent preterm birth trimester specific smoking behavior although women even prior premature birth inherently high risk recurrence women stopped smoking early first trimesters experienced similar preterm birth rates compared nonsmokers however delayed smoking cessation smoking throughout pregnancy significantly increased recurrent premature birth risk smoking cessation potential modifiable risk factor recurrent preterm birth high risk pregnancies study highlights importance early pregnancy smoking cessation especially high risk women prior preterm birth
background biological magnetic resonance data bank bmrb public repository nuclear magnetic resonance nmr spectroscopic data biological macromolecules important resource many researchers using nmr study structural biophysical biochemical properties biological macromolecules primarily maintained accessed flat file ascii format known nmr star format human readable size bmrb entries makes computer readability explicit representation practical requirement almost rigorous systematic analysis results aid use public resource developed package called nmrstarlib popular open source programming language python nmrstarlib implementation efficient design execution library facilities reading writing nmr star version formatted files parsing usable python dictionary list based data structures making access manipulation experimental data natural within python programs saveframe loop records represented individual python dictionary data structures another major advantage design data stored original nmr star easily converted equivalent javascript object notation json format lightweight data interchange format facilitating data access manipulation using python programming language implements json parser generator popular programming languages also developed tools visualize assigned chemical shift values convert nmr star jsonized nmr star formatted files full api reference documentation user guide tutorial code examples also available tested new library current bmrb entries entries parsed without errors nmr star version version formatted files also compared software three currently available python libraries parsing nmr star formatted files pystarlib nmrpystar pynmrstar conclusions nmrstarlib package simple fast efficient library accessing data bmrb library provides intuitive dictionary based interface python programs read edit write nmr star formatted files equivalent jsonized nmr star files nmrstarlib package used library accessing manipulating data stored nmr star files command line tool convert nmr star file format equivalent json file format vice versa visualize chemical shift values furthermore nmrstarlib implementation provides guide effectively jsonizing older scientific formats improving fairness data formats
transforming growth factor beta tgfb regulates cell proliferation differentiation apoptosis matrix homeostasis intimately involved fibrosis tgfb expression increased fibrotic lung diseases idiopathic pulmonary fibrosis chronic inflammatory conditions chronic obstructive pulmonary disease asthma addition exhibiting profibrotic activities protein exhibits profound immune suppressive actions involving innate adaptive responses often aspect tgfb biology overlooked recent investigations demonstrated tgfb causes wide ranging immune suppression including blunting pivotal early innate ifn responses activities permit severe virus infections often followed secondary bacterial infections may last longer augmented inflammation scarring fibrosis loss lung function strategies oppose tgfb actions enhance ifn responses may help ameliorate detrimental consequences infection patients diseases characterized tgfb overexpression inflammation fibrosis
targeted mass information compounds accelerated discovery large volume untargeted data similarity networking advanced clustering structural analogues benefits collection mass information similar compounds triterpene saponins extracted eleutherococcus senticosus leaves esl kind functional tea shown promise relief alzheimer disease work target precursor list tpl generated using similarity networking employed rapidly trace triterpene saponins aqueous extracts esl tentatively identified potentially new triterpene saponins moreover compound database triterpene saponins established successfully applied uncover distribution features esl samples collected different areas elsevier ltd rights reserved
pharmacogenetic studies identified non synonymous single nucleotide polymorphism human opioid receptor mor gene oprm critical genetic variant capable altering efficacy opioid therapeutics date studies explored potential impact oprm polymorphism pharmacological effects buprenorphine bpn potent mor partial agonist kappa opioid receptor antagonist approved fda treatment opioid addiction chronic pain goal studies determine whether mor mediated behavioral effects bpn altered oprm mouse model human oprm snp studies conducted female mice bpn maximal analgesic effect hot plate test significantly blunted mice compared wild type mice similarly bpn induced reduction latency consume food novelty induced hypophagia test blocked entirely mice compared littermates addition mice exhibited marked reductions psychostimulant hyperlocomotor activity compared group contrast reduced immobility forced swim test effect bpn mediated kappa opioid receptors affected genotype studies demonstrate ability oprm snp attenuate analgesic anxiolytic hyperlocomotor effects bpn overall data suggest oprm snp significantly impact clinical efficacy bpn therapeutic applications elsevier ltd rights reserved
paper proposes image encryption scheme based cellular automata self organizing structure set cells cell updated certain rules dependent limited number neighboring cells major disadvantages cellular automata cryptography include limited number reversal rules inability produce long sequences states rules paper non uniform cellular automata framework proposed solve problem proposed scheme consists confusion diffusion steps confusion step positions original image pixels replaced chaos mapping key image created using non uniform cellular automata hyper chaotic mapping used select random numbers image key encryption main contribution paper application hyper chaotic functions non uniform robust key image generation security analysis experimental results show proposed method large key space resistive noise attacks correlation adjacent pixels encrypted image reduced amount entropy equal close ideal
background consistent united nations sustainable development goals gender equality mobile health mhealth programmes aim use communications technology promote empowerment women conducted pre trial analysis data weltel retain study retention hiv care assess gender based differences phone access phone sharing concerns receiving text messages healthcare provider methods april june hiv positive adults screened trial participation two clinics urban slums nairobi kenya proportions men women excluded trial due phone related criteria compared using chi square test gender based differences phone sharing patterns concerns among trial participants similarly compared results individuals screened difference proportion men women excluded phone related criteria value among shared phone women likely men share non household household members participants concerns receiving text messages healthcare provider concerns women discussion study men women equally able participate trial mhealth intervention equitable access urban slums may indicate gender digital divide narrowing settings however gender specific phone sharing patterns concerns regarding privacy must fully considered development scale mhealth programmes
recessive mutations gene reported responsible fxiiia subunit deficiency fxiiia intronic nucleotide changes identified gene investigated silico analysis occasionally supported experimental data reported cases polymorphism determine molecular defects responsible congenital factor xiii deficiency libyan patient molecular analysis performed direct dna sequencing coding regions splice junctions fxiiia subunit gene splicing minigene assay used study effect mutation bioinformatics exploration fulfilled conceive consequences protein duplication straddling border intron exon leads two acceptor splice sites resulting silencing downstream wild splice site caused frame insertion nucleotides mrna four amino acids protein bioinformatic analysis predicts insertion four amino acids affects site calcium binding site disturbs smooth function fxiiia peptide causing factor xiii deficiency study showed small duplication seems weaken original splice site enhance activation new splice site responsible alternative splicing would interesting examine underlying molecular mechanism involved rearrangement copyright wolters kluwer health inc rights reserved
building industry associated several environmental impacts considering total building lifecycle use phase strong influence level impact according literature use phase residential buildings represents energy consumption constitutes water consumption indoor outdoor accounts weight materials used produces waste maintenance repair renovation green building certification programs used north america boma best leed living building challenge aim reduce environmental footprint housing however certifications provide useful framework practices related buildings systems documentary analysis shows adequately take account use phase residential buildings purpose paper show consideration use phase inconsistent impacts associated
background multi scale ranked organizing map coupled implicit function squashing time algorithm rom fast new complex system based artificial neural networks anns able extract features interest computerized eeg analysis minutes eec without preliminary pre processing proof concept study previously published showed accuracy values ranging discerning subjects mild cognitive impairment alzheimer disease healthy elderly people presence deviant patterns simple resting state eeg recordings autism consistent atypical organization cerebral cortex present prompted applying potent analytical systems search eeg signature disease aim study aim study assess effectively methodology distinguishes subjects autism typically developing ones methods fifteen definite asd subjects males females age range mean value ten typically developing subjects males females age range mean value included study patients received autism diagnoses according dsm criteria subsequently confirmed ados scale segment artefact free eeg lasting seconds used compute input values subsequent analyses rom fast coupled well documented evolutionary system able select predictive features twist created invariant features vector input eec supervised machine learning systems acted blind classifiers results overall predictive capability machine learning system sorting autistic cases normal control amounted consistently kind systems employed using training testing protocol using leave one protocol similarities among ann weight matrixes measured apposite algorithms affected age subjects suggests anns read age related eeg patterns rather invariant features related brain underlying disconnection signature conclusion pilot study seems open new avenues development non invasive diagnostic testing early detection asd elsevier rights reserved
research examined children evaluation public private prosocial giving whether evaluation would predict actual behavior tested children years old china children socialized call positive attention study significant age related change found younger children evaluated public acts prosocial giving favorably private acts whereas older children showed opposite pattern study replicated findings study also showed children evaluation public versus private giving predicted actual behavior communicating prosocial giving findings first show age related changes children understanding generosity predict reputation management behavior elsevier inc rights reserved
introduction determination amount body fat carried methods different levels sensitivity specificity clinical practicality cost absorptiometry dual energy ray absorptiometry dxa considered gold standard method quantification fat high costs requires longer running time compared anthropometry objective evaluate correlation methods estimate central fat adult living hiv aids methods cross sectional study convenience individuals diagnosed hiv started antiretroviral treatment collected anthropometric information weight height waist circumference abdominal skinfold supra iliac amount central fat according information dxa results estimate central fat using anthropometric information developed mathematical equations three dxa coefficients models equal conclusion anthropometric measurements used estimate amount central fat easy measurement clinical practicality suggest central fat monitoring included clinical treatment protocol thus contributing diagnosis lipodystrophy prevention metabolic changes
magnetorheological fluid mrf smart material whose rheological properties varied magnetic field applied development semiactive dampers variety applications material essentially consists suspension magnetic particles nonmagnetic carrier fluid important understand magnetic response mrf dependence several parameters improving designing mrf devices purpose work develop constitutive model describes behavior shear yield stress material function magnetic field composition taking account material changes rheology apparent viscosity according magnetic field magnetically induced state transition proposed use state transition equation constitutive model shear yield stress defined consisting expression relates composition material stimulus applied also associates volume fraction particles magnetic field material composes particles
backgroundwhile united states seen increased attention policymakers rights parents disabilities limited understanding health economic well parents intellectual impairments study compares health economic well mothers without intellectual impairments methodsthis descriptive exploratory study secondary analysis fragile families child wellbeing study study includes subsample mothers three year old children including mothers intellectual impairments without intellectual impairments resultsus mothers intellectual impairments likely report serious health conditions less instrumental support live poverty receive public benefits experience certain material hardships conclusionfindings study indicate need policies programmes support parents intellectual impairments addressing health economic needs
rainwater harvesting system rhs designed waste treatment facility located near town mirandela northern portugal used washing vehicles equipment cleaning outside concrete asphalt floors watering green areas water tank volumes representing efficiency calculated ripple method different results depending two consumption scenarios adopted irrigation rhs design based precipitation record spanning rather long period decades calculated storage capacities fulfilled water demand even prolonged droughts occurred timeframe however drought events rather scarce values considered oversized replaced optimal volumes notwithstanding new volumes solely half original values projected rhs efficiency remained high around probability system failure efficiency stayed low order scenarios economic savings related optimization noteworthy investment return periods decreased substantially original optimized solutions high efficiency low storage capacity typical low demanding applications rainwater harvesting water availability largely exceeds water demand say demand fractions low based results literature review covering ample geographic distribution describing large number demand fraction scenarios defined threshold generally distinguish low high demanding rhs applications elsevier rights reserved
years stealth drug delivery synonymous nanoparticulate formulations intravenous dosing putative determinants stealth applications molecular weight packing density hydrophilic polymer commonly poly ethylene glycol peg forms steric barrier surface nanoparticle current study examined potential translation concepts learned stealth technology intravenous administration oral drug delivery specifically enhance drug exposure administration oral lipid based formulations lbfs containing medium chain triglycerides mct mct lbfs rapidly digested gastrointestinal tract typically resulting losses solubilisation capacity supersaturation drug precipitation non ionic surfactants containing stealth peg headgroups incorporated mct lbfs attempt attenuate digestion reduce precipitation risk enhance drug exposure stealth capabilities assessed measuring degree digestion inhibition resulted steric hindrance enzyme access oil water interface drug loaded lbfs assessed maintenance solubilising capacity vitro digestion evaluated vivo rats data suggest structural determinants stealth lbfs mirror parenteral formulations key factors molecular weight peg surfactant headgroup packing density peg chains interface interestingly data also show presence labile ester bonds within pegylated surfactant also impact stealth properties lbfs digestible surfactants requiring peg similar mol non digestible ether based surfactants similar mol shield lipidic cargo vitro evaluation drug solubilisation digestion showed stealth lbfs maintained drug solubilisation drug load reduced supersaturation comparison digestible counterparts trend also reflected vivo relative bioavailability drug administration two stealth lbfs increased comparison analogous digestible non stealth formulations results current study indicate self assembled stealth lbfs potential novel means improving lbf performance elsevier rights reserved
previous studies demonstrated klf critical transcription factor promotes odontoblastic differentiation dental papilla cells klf mrna found regulated multiple micrornas mirnas competitive endogenous rnas cernas group transcripts post transcriptionally regulating competing common mirnas however regulation klf cernas odontoblastic differentiation remains unknown study predicted group potential klf cernas bioinformatics approach examined expression klf five interested potential cernas including using real time pcr odontoblastic differentiation mdpct expression levels klf significantly upregulated process situ hybridization verified spi expressed klf differentiating mature odontoblasts vivo knockdown spl using sirna resulted significant reduction laf vice visa interaction confirmed mirna dependent common mirnas klf spi predicted among mir mir mir able downregulate klf spl expression separate overexpression mdpct cells dual luciferase assays showed mirnas separately regulated utrs klf spi regulation klf utr spl sirna abolished three mirnas binding sites mutated klf utr therefore results indicate functions cerna klf odontoblastic differentiation competing mir mir mir elsevier ltd rights reserved
development morphology possible functional activity cajal retzius cell developing human cerebral cortex explored herein extracortical origin essential neuron neocortex first lamina receives inputs afferent fibers reach first lamina early development although origin function original afferent fibers remain unknown target first lamina sole neuron neuron orchestrates arrival size stratification pyramidal neurons ependymal origin neocortex gray matter axonic terminals spread radially horizontally throughout entirety first lamina establishing contacts dendritic terminals gray matter pyramidal cells regardless size location eventual functional roles neuron axonic terminals spread radially horizontally throughout first lamina neuronal body undergoes progressive developmental dilution locating adult brain become quite difficult neuron bodies probably retained older regions neocortex axonic collaterals spread throughout recent ones eventually extend great majority cortical surface neocortex first lamina evolution composition intertwined mutually interdependent possible understand evolving morphology without understanding first lamina first lamina composition structural functional organizations obtained different staining methods may utterly different differences added unnecessary confusion nature essential emptiness observed hematoxylin eosin preparations commonly used contrast sharply concentration dendrites cortex largest obtained using special map stain dendrites golgi preparations demonstrate numerous dendritic axonic terminals compose first lamina basic structure high power microscopic views golgi preparations demonstrate intimate anatomical functional interrelationships among dendritic axonic terminals well synaptic contacts essential morphology changes progressively modified first lamina increase thickness number terminal dendrites subsequent maturation neuron variable morphologic appearance source controversy morphology depends first lamina thickness may quite variable among different mammals rodents commonly used experimental mammal first lamina thickness number horizontal expansion dendrites fraction humans differences reflected morphology among mammals including humans thought representing new types neurons
comparing iter experimental fusion machine construction next step test fusion power plant demowill characterized long pulse steady state operation much higher plasma volume fusion power substantially increased level neutron gamma fluxes require reducing physical access plant means conventional diagnostics fusion plasma control suitable demo development diagnostics along machine design primary task test plant deuterium tritium fuel ratio temperature among important parameters control paper novel technique core fuel ratio temperature diagnostics proposed based measurements comparison rates gamma gamma nuclear reactions take place hot deuterium tritium plasma based detection high energy gamma rays diagnostic robust efficient require direct access plasma could included loop burning plasma control system feasibility diagnostic experiments jet iter also discussed
infrared emissions aircraft used detect track lock target man portable air defence systems manpads emerged major cause aircraft helicopter loss therefore signature studies important counter threat survivability enhancement important aspect stealth technology paper reviews contemporary developments discipline particular emphasis signature prediction aerospace vehicles role atmosphere signature analysis relation signature level target susceptibility illustrated also signature suppression systems countermeasure techniques discussed highlight effectiveness implications terms penalties elsevier ltd rights reserved
rapid socioeconomic development water pollution emergency become increasingly common could potentially harm environment human health especially heavy metal pollution paper investigate pollution emergency occurred pearl river network china build migration transformation model heavy metals simulate spatiotemporal distribution concentrations various scenarios pollution emergency foshan city moreover human health hazard carcinogenic risk local residents foshan city evaluated primary conclusions follows number carcinogen affected people per year scenario reached frequency year time specifically number people cancer per year area datang lubao nanbian waterworks accounting total number per year frequency years time lubao waterwork one extremely high high risk grade besides risk grade datang nanbian xinan shitang jianlibao waterworks extremely high high grade frequency year time pollution accidents level occurs concentration decreases low level water migration distance least based health risk assessment pollution study gives recommendation distance keep tidal river network pearl river delta factories existing possibility heavy metal pollution drinking water source public protect hazardous effects higher levels heavy metal
promising photocatalyst driven visible light bioi attracted attention past years however surface structure properties biol important place photocatalytic investigated details end density functional theory performed calculate structural electronic properties four low index stoichiometric surfaces bioi found relaxation low index bioi surfaces relatively small especially surface thus surface energies biol relatively small moreover surface states bottom conduction band first layer except surface maybe capture photo excited carriers stable terminated planes dangling bonds cleaved broken bonds case surface dangling bond density atoms surface zero per square nano therefore surface thermodynamically lowest energy surface biol predominant surface final remark dangling bonds density bismuth atoms determines surface energy also surface relaxation finally equilibrium morphology bioi also proposed provided determined wulff construction results help better understand underlying photocatalytic mechanism related bioi surfaces provide theoretical support experimental studies bioi based photocatalyst future elsevier rights reserved
tennis popular incorrect action produces sports injuries knowledge sports biomechanics used sports injury research tennis two mainly classical research methods tennis sports biomechanics theoretical research experimental study paper introduces technical features two research methods theoretical research mainly based model experimental study mainly based three systems kinematics dynamics biological measurement differences among compared order provide overall ideas study sports injury tennis
objective evaluate incidence sports injuries college athletes institution methods athletes modalities interviewed presence type injury type treatment time withdrawal based questionnaire injury surveillance system iss data analyzed graphs tables injury prevalence gender age site injury modality also analyzed average time withdrawal athletes returning sports practice new lesions results observed athletes showed type injury similar incidence genders frequent injuries anterior cruciate ligament acl ankle sprain average withdrawal time weeks acl injury greater impact college sports career especially given time withdrawal conclusion frequent injury acl occurred frequently indoor sports handball volleyball highest number cases treated surgery longer average withdrawal time studies needed create larger database order schedule preventive measures amateur athletes
paper new intelligent robot motion control architecture highly accurate model free fuzzy motion control proposed order achieve improved robot motion accuracy dynamic performance architecture combines mamdani fuzzy proportional conventional integral plus derivative controller feedback part system takagi sugeno kang fuzzy controller feed forward nonlinear part fuzzy controller improves performance nonlinear system tsk fuzzy controller uses tsk fuzzy inference system based extended subtractive clustering method integrates information joint angular displacement velocity acceleration torque identification advantage kind model free control uses information directly input output nonlinear system without complex robot model computation order decrease control system sensitivity dynamical uncertainty furthermore parametric search clustering parameters extended subtractive clustering secures high accuracy system identification consequently proposed model free fuzzy motion control benefits advantages two kinds fuzzy system incorporates flexible design good performance simple conception also ensures precise motion control great robustness comparisons intelligent models results numerical studies bar planar parallel mechanism show effectiveness competitiveness proposed control
discoveries defective molecular composition epidermal barrier epidermal protein filaggrin atopic eczema atopic dermatitis proved crucial understanding disease aetiology remains fully elucidated epidermal barrier one interface microbial world immune system recent advances molecular technology demonstrated first time true scale normal human microbiome changes seen disease states review article discuss role human microbiome aetiology maintenance role staphylococcus aureus within skin microbiome examined addition role bacteria fungi identified using novel culture independent methods significant contribution gut microbiome manipulation via probiotic use also reviewed emphasise microbiome separate systems including gut significant role play manifestation cutaneous disorder date lack studies investigating whether changes lung microbiome may play role early interaction microbiome immune system via multiple routes skin gut lung could feasibly affect risk subsequent development atopic diseases making management decisions patients clinicians must mindful role microbiome
paper describes novel line learning approach radial basis function rbf neural network based rbf network individually tunable nodes fixed small model size weight vector adjusted using multi innovation recursive least square algorithm line residual error rbf network becomes large despite weight adaptation insignificant node little contribution overall system replaced new node structural parameters new node optimized proposed fast algorithms order significantly improve modeling performance proposed scheme describes novel flexible fast way line system identification problems simulation results show proposed approach significantly outperform existing ones nonstationary systems particular
objectives three direct oral anticoagulants doacs dabigatran apixaban rivaroxaban widely used clinical practice patients requiring perioperative interruption doacs heparin bridging still discussion show first time influence concomitantly used doacs heparins laboratory assays methods spiking experiments healthy donors nine patients treated doacs investigated measurement doacs heparins performed routine methods acl top hemoclot direct thrombin inhibitor coachrom diagnostica austria coamatic heparin chromogenix usa calibrated rivaroxaban apixaban unfractionated heparin ufh low molecular weight heparin lmwh additionally reagent recombiplastin aptt reagent synthasil instrumentation laboratory germany doacs additionally quantified liquid chromatography mass spectrometry linear regression model used estimate effect doac prestimulation results influence dabigatran could demonstrated anti testing methods lmwh ufh rivaroxaban apixaban fxa inhibiting drugs affected anti testing methods specific ways compared heparin alone measurement heparins samples basic concentration doacs displays dramatic increase samples patients therapeutic intake doacs spiked ufh lmwh showed expected pharmacokinetic profiles increased pharmacodynamic effects conclusion direct thrombin fxa inhibitors exhibit distinct effects assay results used concomitantly heparins interactions must considered interpretation assay results bridging therapy
backgroundevidence based self help recommended first stage treatment mild moderate eating disorders provision guidance enhances outcome literature evaluating exclusively guided self help gsh systematically reviewed methodsthe aim establish effectiveness gsh reducing global eating disorder psychopathology abstinence binge eating compared controls results pooled using random effects meta analysis heterogeneity explored using metaregression resultsthirty randomised controlled trials met inclusion criteria results showed overall effect gsh global eating disorder psychopathology binge abstinence strong evidence association diagnosis binge eating disorder binge abstinence discussioncurrent interventions need adapted address features binge eating research required help understand effectiveness gsh children young people invariably high dropout rates technology enhance interventions copyright john wiley sons ltd eating disorders association
thiamine vitamin deficiency plays major role etiology wernicke encephalopathy severe neurological disorder induces selective neuronal cell death neuroinflammation endoplasmic reticulum stress oxidative stress brain commonly observed many aging related neurodegenerative diseases alzheimer disease parkinson disease huntington disease progressive supranuclear palsy psp however underlying cellular molecular mechanisms remain unclear progress line research hindered due lack appropriate vitro models neurons derived human induced pluripotent stem cells hipscs provide relevant powerful tool research pharmaceutical environmental neurotoxicity study first time used human induced pluripotent stem cells hipscs derived neurons icell neurons investigate mechanisms induced neurodegeneration showed caused concentration duration dependent death icell neurons induced stress evident increase stress markers grp xbp chop atf phosphorylated eif alpha cleaved caspase also triggered oxidative stress shown increase expression dinitrophenyl dnp hydroxynonenal hne stress inhibitors stf salubrinal antioxidant acetyl cysteine nac effective alleviating induced death icell neurons supporting involvement stress oxidative stress establishes icell neurons novel tool investigate cellular molecular mechanisms induced neurodegeneration elsevier inc rights reserved
background aims incidence menstrual symptoms reported high cyclic women symptoms including anxiety pain might associated cortisol receptors widely distributed brain areas associated behavior therefore current study aimed assess cortisol awakening response car throughout menstrual cycle correlate pain perception trait anxiety materials methods car assessed measuring salivary cortisol min following awakening women age years various stages menstrual cycle menses midcycle luteal premenstrual phases progesterone estradiol concentrations also determined saliva samples assess cyclic changes self reported pain trait anxiety menstrual symptoms assessed visual analog scale vas state trait anxiety inventory stai daily record severity problems drsp respectively results estradiol significantly elevated midcycle period remained high early luteal phase progesterone increased luteal phase post awakening cortisol values increased midcycle luteal phase premenstrual phase blunted flat car positive significant correlations found cortisol estradiol cortisol progesterone estradiol progesterone premenstrual symptom scores higher menses premenstrual phases midcycle luteal phases pain perception highest menses followed premenstrual phase conclusions car blunted menses suggesting cortisol might play phase specific role regulation cycle additionally premenstrual symptoms including pain severe ovarian steroid levels reduced menses premenstrual phase elsevier ltd rights reserved
older adult population continues grow prevalence chronic diseases also increasing leading need novel ways managing large population patients one solution focus informal caregivers informal caregivers already make substantial contribution nation healthcare finances patient health outcomes caregivers also derive benefits caring family member friend however uncommon individuals experience negative health consequences often called burden care called care without burdens must frequently make significant lifestyle adjustments impact health therefore caregivers effective caring caregivers must focus medicine twenty first century
reverse engineering demands fast accurate measuring method obtain surface model object computer aided design cad model available blending advantages contact probes non contact scanners trend reverse engineering development past years current research hybrid reverse engineering system focuses sensor selection scanning path planning coordinate system registration unification lacks interaction data groups touch probe laser sensor objective research directed toward improving data accuracy reduced amount data points without complex instrument integration accomplished combining advantages contact probes non contact scanners meanwhile offsetting disadvantages research data laser sensor strategically selected based local surface variation coordinate measuring machine cmm touch probe used enhance data accuracy cell merging algorithm implemented reduce amount data based newly proposed concept break points hermit bicubic relation maintained among neighboring sampling points hybrid reverse engineering process going end paper examples presented show effectiveness methodology
background study aim changed thigh muscles action balance cause sports injuries aim investigation knowledge effect thigh muscles fatigue resistance knee flexor extensor ext muscles mean work power ratio material methods fourteen amateur male handball players participated tests carried dynamometer system using knee isokinetic flexion extension movements angular velocity degrees five repetitions degrees repetitions concentric contractions mean thigh muscles ext muscles mean ratios calculated first ten last ten repetitions correlation thigh muscles peak torques tau max velocity degrees degrees first last ten repetitions determined results mean produced knee last ten movements smaller first ten motions knee ext ext last ten motions lower first ten movements ext ext therefore knee joint trauma may occur probably fatigue appearance positive correlation thigh muscles tmax first ten last ten knee movements confirms strength training muscles improve maximal strength also fatigue resistance conclusion significant positive correlation thigh hamstrings quadriceps femoris muscles peak torques mean work power muscles first ten last ten knee flexion extension movements confirms strength training muscle groups improve maximal strength also fatigue resistance muscles
process design testability dft procedure test points addition significantly time consuming especially systems become complex resolve problem efficient method allocate test points based multi signal flow graph proposed paper first dependency matrix describes relationship signals candidate test points presented assuming output modules multi signal flow graph considered candidate test point thus test point allocation problem formalized searching optimal candidate test point set detect isolate signals genetic algorithm applied dependency matrix search optimal test point set finally proposed method examined multi signal flow graph result shows proposed method allocate optimal test points acceptable time
river ganga largest perennial one sacred rivers india supports lifeline major population urban rural areas existing river basin river chief source water supply power generation river borne transport expansion urban industrial belt however river receives huge amount untreated wastewater imbalances nutrient concentration many points along stretch therefore present study focused estimate water pollution using water quality indices opi national sanitation foundation index nsfwqi comprehensive pollution index cpi heavy metal pollution index hpi identify imbalance nutrients heavy metals etc river also probability health risk might occur drinking river water classified using risk assessment index rai water samples collected post pre monsoon months year nine sampling locations haridwar garhmukteshwar results indicate water quality river ganga unsuitable drinking sampling months average nsfwqi found cpi post pre monsoon respectively river water found severely contaminated due heavy metals hpi indicates human health risk rai therefore suggested river water must treated balance nutrient concentration used drinking comparative analysis indices nsfwqi cpi found better suitable indices classify status water quality
paper propose robust methodology assess value microblogging data forecast stock market variables returns volatility trading volume diverse indices portfolios methodology uses sentiment attention indicators extracted microblogs large twitter dataset adopted survey indices aaii usmc sentix diverse forms daily aggregate indicators usage kalman filter merge microblog survey sources realistic rolling windows evaluation several machine learning methods diebold mariano test validate sentiment attention based predictions valuable compared autoregressive baseline found twitter sentiment posting volume relevant forecasting returns index portfolios lower market capitalization industries additionally sentiment informative forecasting returns moreover twitter sentiment indicators useful prediction survey sentiment indicators results confirm usefulness microblogging data financial expert systems allowing predict stock market behavior providing valuable alternative existing survey measures advantages fast cheap creation daily frequency elsevier ltd rights reserved
introduction evolutionarily selected billions years interactions biomolecules natural products continue major source pharmaceuticals pharmaceutical companies scaled natural product discovery programs favor synthetic chemical libraries due major challenges high rediscovery rates challenging isolation low production titers propelled advances dna sequencing synthetic biology technologies insights microbial secondary metabolism provided inspired number strategies address challenges areas covered review highlights importance genomics metagenomics natural product discovery provides overview technical conceptual advances offer unprecedented access molecules encoded biosynthetic gene clusters expert opinion genomics metagenomics revealed nature remarkable biosynthetic potential vast chemical inventory prioritize systematically mine novel chemical scaffolds desirable bioactivities coupled synthetic biology genome engineering technologies significant progress made identifying predicting chemical output biosynthetic gene clusters well optimizing cluster expression native heterologous host systems production pharmaceutically relevant metabolites derivatives
objective assess whether hysteroscopic sterilization feasible effective preventing pregnancy secondarily identify risk factors failure hysteroscopic sterilization design systematic review meta analysis setting applicable patient women undergoing hysteroscopic sterilization intervention hysteroscopic sterilization commercially available system ovabloc intra tubal device essure system adiana permanent contraception system main outcome measure successful placement first attempt confirmed correct placement complications incidence pregnancy risk factors placement failure hysteroscopic sterilization result citations identified articles eligible analyses randomized controlled trials rcts identified cohort studies six articles concerned ovabloc essure two adiana sterilization probabilities successful bilateral placement first attempt ovabloc essure adiana respectively ranges probabilities successful bilateral placement could pooled substantial heterogeneity months cumulative pregnancy rate adiana reliable pregnancy rates sterilization ovabloc essure method could calculated three hysteroscopic techniques incidence complications severity studied adequately remains unclear also found little evidence identify risk factors placement failure conclusion sterilization hysteroscopy seems feasible effectiveness risk factors failure sterilization remain unclear owing poor quality evidence currently applied hysteroscopic sterilization techniques coming new techniques must evaluated properly feasibility effectiveness appropriate rcts observational studies sufficient power complete long term years follow data unintended pregnancies complications needed american society reproductive medicine
messages political elites interact individual traits citizens spur intergroup aggression building research social psychology expect places protracted conflict violent rhetoric elites enough mobilize antagonism toward outgroup especially among generally less apt hostile toward outgroup present results two large survey experiments first conducted young jewish israeli adults across israel second nationally diverse sample adults india results show mild fighting words battle fight combined reference outgroup provoke significantly greater support policies harm outgroup among citizens effect largest among individuals low outgroup prejudice low aggressive personality traits people usually less inclined support policies hurt outgroup effects violent rhetoric persist even policies rhetoric help outgroup work highlights importance considering individual traits contextual factors together understand full impact study intergroup conflict
increasing complexity new breed distributed intelligent systems internet things require diversity languages protocols tamed design programming best practices interest also growing including human factor advocated ambient intelligence ami research field whose focus transparently intelligently supporting people new design methodologies increasingly needed tool box new electronic computer engineers teaching strategies devised allow students acquire systems level view instead getting lost technology oriented approaches paper describes study carried two academic years course ami politecnico torino italy course project based learning approach adopted students design prototype ami system progress closely monitored throughout semester paper presents learning goals teaching strategies analyzes learning outcomes qualitative quantitative points view highlights lessons learned process
background early childhood characterized dramatic gains emotion regulation skills support social adjustment mental health understanding physiological substrates healthy emotion regulation may offer new directions altering trajectories toward initiation escalation substance abuse describe intersections parasympathetic sympathetic tone emotion regulation prosocial behavior high risk sample preschoolers method fifty two year old children completed assessment attention regulation response affective stimuli cardiac respiratory sinus arrhythmia index parasympathetic tone pre ejection period marker sympathetic activation recorded rest children engaged social interactions mothers unfamiliar research assistant mothers reported children emotional reactivity prosocial behavior results controlling age psychosocial risk higher parasympathetic tone predicted better attention regulation response angry emotion higher levels prosocial behavior whereas reciprocal pattern higher parasympathetic tone lower sympathetic arousal predicted better attention response positive emotion lower emotional reactivity children exposed fewer risk factors higher levels maternal warmth able sustain high level parasympathetic tone interaction episodes conclusions findings suggest autonomic measures represent biomarkers socio emotional competence young children also point importance early experiences establishment physiological regulation promise family based intervention promote healthy emotion regulation prevent substance dependence high risk populations university kentucky center drug abuse research translation published elsevier ireland ltd
bayesian system identification attracted substantial interest recent years inferring structural models based measured dynamic response structural dynamical system focus paper bayesian system identification based noisy incomplete modal data impose spatially sparse stiffness changes updating structural model end based similar hierarchical sparse bayesian learning model previous work propose two gibbs sampling algorithms algorithms differ strategies deal posterior uncertainty equation error precision parameter sample conditional posterior probability density functions pdfs structural stiffness parameters system modal parameters effective dimension gibbs sampling low iterative sampling done three conditional posterior pdfs correspond three parameter groups along sampling equation error precision parameter another conditional posterior pdf one algorithms integrated nuisance parameter nice feature computational perspective necessary solve nonlinear eigenvalue problem structural model effectiveness robustness proposed algorithms illustrated applying iase asce phase simulated experimental benchmark studies goal use incomplete modal data identified possible damage detect assess spatially sparse stiffness reductions induced damage past current focus meeting challenges arising bayesian inference structural stiffness serves strengthen capability vibration based structural system identification methods also much broader applicability inverse problems science technology system matrices inferred noisy partial information eigenquantities elsevier rights reserved
paper explores advantages publish subscribe middleware offer implementation efficient reliable electric vehicle charging control infrastructure propose distributed optimization publish subscribe dops framework distributed optimization charging works top pub sub middleware extends support network aggregation evaluation deployed dops testbed consisting virtual machines connected via vlan network compared three different communication schemes centralized decentralized decentralized aggregation results show evs centralized approach faster however trends reveal evs decentralized approaches offer better performance moreover demonstrate network aggregation feature dops doubles performance decentralized approach results thus confirm distributed control infrastructures benefit using pub sub middleware
computing performance one key problems embedded systems high resolution face detection applications improve computing performance embedded high resolution face detection systems novel parallel implementation embedded face detection system established based low power cpu accelerator heterogeneous many core architecture first basic cpu version face detection prototype implemented based cascade classifier local binary patterns operator second prototype extended specified embedded parallel computing platform called parallella consists xilinx zynq adapteva epiphany third face detection algorithm optimized adapt parallella architecture improve detection speed utilization computing resources finally face detection experiment conducted evaluate computing performance proposal paper experimental results show proposed implementation obtained consistent accuracy dual core arm achieved times speedup dual core arm experiment results prove proposed implementation significant advantages computing performance
knowledge peanut drying parameters temperature relative humidity ambient air temperature relative humidity air blown peanuts kernel moisture content essential managing dryer optimal drying rate optimal drying rate required preserve quality desired flavor current peanut drying process parameters elusive real time either measured measured periodically operator peanut drying monitoring system controlled embedded microcontroller consisting relative humidity temperature sensors microwave peanut moisture sensor developed monitor drying parameters real time deployed peanut harvest season peanut buying point central georgia usa placed drying semitrailers monitor shell kernel moisture content temperature drying peanuts temperature relative humidity exhaust air peanuts relative humidity air blown peanuts real time shell kernel moisture content determined standard error performance moisture content compared reference oven drying method data drying parameters time stamped stored compactflash card every used assess efficiency dryer control settings ambient air conditions measured site weather station results study support value monitoring system show implementation system dryer control potential saving buying point current economical context much annually costs electric energy propane
paper discussion forward problem inverse problem beams strength materials known load case beam certainly determine shearing force diagram bending moment diagram conversely may variety statically determinate statically indeterminate constraint conditions furthermore solution statically indeterminate constraint conditions agree given shearing force diagram bending moment diagram general way
social cognition fundamentally interpersonal individuals behaviour dispositions critically affect interaction partners information processing however cognitive neuroscience studies partially methodological constraints remained largely perceiver centric focusing abilities motivations goals social perceivers largely ignoring interpersonal effects address knowledge gap examining neural bases perceiving emotionally expressive inexpressive social targets sixteen perceivers scanned using fmri watched targets discussing emotional autobiographical events perceivers continuously rated target emotional state eye gaze direction effects targets emotional expressivity perceiver brain activity depended task set perceivers explicity attended targets emotions expressivity predicted activity neural structures including medial prefrontal posterior cingulate cortex associated drawing inferences mental states perceivers instead attended targets eye gaze target expressivity predicted activity regions including somatosensory cortex fusiform gyrus motor cortex associated monitoring sensorimotor states biological motion findings suggest expressive targets affect information processing manner depends perceivers goals broadly data provide early step toward understanding neural bases interpersonal social cognition
purpose aim present study evaluate role hypothyroidism cause hyponatremia clinical model iatrogenic acute hypothyroidism due thyroid hormone withdrawal prior ablative radioactive iodine rai therapy total thyroidectomy methods study group consisted differentiated thyroid cancer dtc patients women men plasma concentration thyroid stimulating hormone tsh sodium evaluated total thyroidectomy pre tsh pre day rai therapy post tsh post results frequency hypothyroidism associated hyponatremia pre significantly higher post meq moreover linear correlation identified pre post conclusion iatrogenic acute hypothyroidism related hyponatremia uncommon however significant reduction transition euthyroidism iatrogenic hypothyroidism value pre viewed parameter considered since acts independent risk factor development hyponatremia patients pre close lower limit normal range may deserve closer monitoring
power factor correction pfc converter commonly used many applications nowadays high power applications boost pfc converter operated continuous conduction mode usually employed however high line light load condition converter operates discontinuous conduction mode leads erroneous input current sampling results low power factor high total harmonic distortion thd moreover effect emi filter capacitor causes displacement input current input voltage paper proposes digital control method improve reduce thd using current sample correction algorithm duty ratio feed forward current controller emi filter capacitance current injection algorithm increase reduction thd demonstrated experiments boost pfc converter
purpose review purpose review revise current evidence trigemino vascular system tvs neuropeptides potential biomarkers chronic primary headaches mainly chronic migraine recent findings within sensory neuropeptides released activated trigeminal nerve calcitonin gene related peptide cgrp levels seem good biomarker acute migraine somewhat sensitive specific cgrp however increased patients suggests cgrp neuropeptide involved migraine pain generation maintenance data sensory neuropeptides inconsistent neurokinin substance absent amylin cholecystokinin among parasympathetic neuropeptides vasoactive intestinal polypeptide vip increased interictally least migraine cases ictally pituitary adenylate cyclase activating peptide pacap shown increased ictally jugular blood interictal peripheral data indicate increase data parasympathetic peptides finally potential marker glial tvs activation studied inconsistent results migraine patients summary current data tvs neuropeptides potential migraine biomarkers must taken caution even promising case cgrp know certainty whether increased levels reflection tvs activation reliability homogeneity different laboratory tests influence measurements short half life many peptides preventive treatments one limitation would whether described increases levels neuropeptides cgrp specific migraine versus headaches
cytochromes cyps play important role metabolism xenobiotics various endogenous substrates crucial component microsomal monooxygenase system cyps involved numerous protein protein interactions however mechanisms underlying molecular interactions components monooxygenase system still need better characterization study thermodynamic parameters paired interactions mammalian cyps cytochromes cyb evaluated using surface plasmon resonance spr based biosensor biacore analysis pairs cyb cyp complexes formed nine different isoforms mammalian cyps two isoforms human cyb shown thermodynamically complexes subdivided enthalpy driven entropy driven groups formation enthalpy driven complexes observed case microsomal cyps allosterically regulated cyb cyba cypa cybacypa cyba cypa entropy driven complexes formed cyb effect cyp activity cyba cypa cyba cypb cybb cypa results study suggest interactions determining protein clustering indirectly linked monooxygenase functioning positive delta values typical interactions may associated displacement solvation shells proteins upon clustering cyb cyp complex formation accompanied allosteric regulation cyp activity cyb enthalpy dependent elsevier inc rights reserved
entrepreneurship literature proven efficacy experiential collaborative learning approach promotes entrepreneurial capabilities risk taking positive thinking vision intuitive decision making creative problem solving managing interdependency tolerating ambiguity innovation advance propose deleuzian inspired theoretical framework entrepreneurship learning around innovation based rhizomatic perspective offer illustrative case identify advantages challenges rhizomatic approach learning
paper provides state art review design construction multiple span suspension bridges starts brief introduction key issues associated multi span suspension bridges gives historical review bridge form together list multi span suspension bridges constructed present day paper looks compares deflection characteristics classic suspension bridge multi span suspension bridges paper outlines problems associated bridge form primarily caused increased flexibility ways overcome actual bridges exist formerly existed referred paper also looks current proposed future projects using multiple span suspension bridges much recent work subject carried china translations abstracts recent chinese papers included appendix paper
backgroundthe ability understand manage emotional experience critical children health study confirmed validity feel hif questionnaire measure children emotional arousal regulation exploring associations measures emotional social functioning methodsthe sample comprised italian students aged years attended schools interested study aims participants completed item hif scale measures emotional self efficacy social desirability factor structures assessed using confirmatory factor analysis invariance age gender internal consistency temporal stability concurrent validity also tested resultsa factor model identified frequency intensity positive emotion items negative emotion items positive negative emotion control items factor structure invariant across age gender groups hif displayed moderate longitudinal stability month period low social desirability effect positive emotion positively associated social acceptance visibility negatively social withdrawal conclusionsthe hif reliable valid measure research school intervention promoting students emotional mental health
background light therapy accepted treatment option least seasonal affective disorder sad aim critically evaluate treatment effects bright white light bwl depressive symptoms sad non seasonal depression methods systematic review performed according prisma guidelines pubmed embase psycinfo searched december june randomized controlled trials published peer reviewed journals study quality assessed checklist developed swedish council technology assessment health care studies high medium quality used meta analyses results eight studies sad two studies non seasonal depression met inclusion quality criteria effects sad estimated two meta analyses first week week bwl reached statistical significance two three weeks treatment standardized mean difference smd respectively second meta analysis endpoint data showed smd indicates advantage bwl meta analysis performed non seasonal depression due heterogeneity studies limitations analysis restricted short term effects bwl measured mean changes scores derived sigh sad sigh sad self report hdrs rating scales conclusions studies bwl considerable methodological problems results published meta analyses highly dependent study selection even though quality criteria introduced selection procedures studies results carefully scrutinized evidence unequivocal elsevier rights reserved
manuscript presents steady state stability analysis lcl using frequency plot careful analysis favours lcl fine stability region also paper presents comparative estimation conventional proportional integral derivative pid controller genetic algorithm based pid controller modified lcl controllers simulated using matlab performance analyzed result analysis shows supremacy based pid controller conventional pid control method design simulation experimental results khz based lcl resonant converter presented script work applicability philips arm advanced risc machine processor lpc also investigated implementing based pid controller marine applications
real time dynamic hardware loop hil simulator rtx real time subsystem rtss developed using labview language main idea work determine feasibility accuracy widely available highly competitive commercial products personal computers rtss alternative conventional prohibitive real time simulators dynamic studies power systems implemented system self contained heavy duty gas turbine governor synchronous mva machine simplified electrical network hil simulator customized interact static exciter role hil simulator provide real time digital analog signals static exciter systems ses simulate mechanical electrical components closed loop fixed step solver applied well known numerical solution method sophisticated yet exceptionally economic hil simulator provides engineers safe environment analyze dynamic performance static exciters investigate natural restraints functionalities also provides safe environment analyze naturally destructive tests
vortex flowmeter installed piping measure fluid flow rate piping easily disturbed strong transient impact application fields components impacting pipeline manual knocking pipe opening closing valves strong transient impact picked vortex flow sensor makes vortex flowmeter output wrong measurement results current commonly used digital signal processing method nothing solve problem experimental setup built laboratory study impact interference large number vortex flow sensor output signals collected characteristics transient impacts outputted vortex sensor analyzed describe type signal quantitatively pattern transient impact signal amplitudes increase suddenly attenuate gradually segmented kalman filter based digital signal processing method proposed according pattern data segment containing strong transient impact found first transient impact power reduced filtering data segment second spectral analysis filtered signal maximum peak spectrum extracted vortex flow signal finally algorithm implemented real time low power microcontroller gas water flow experiments conducted verify validity reliability antistrong transient impact algorithm
increasing number people dementia ageing home sweden countries order meet safety requirements knowledge persons dementia experience risks required aim study explore better understand persons dementia living home experience risks daily life handle situations twelve persons dementia interviewed using open ended questions data analyzed using content analysis approach findings showed participants experienced situations fraught risks daily life unfamiliar confusing previously familiar places became unfamiliar details come together uncertain actually happened participants handled situations order reduce risks described
paper proposes system identification method estimating virtualised software system dynamics within framework hammerstein wiener model building authors previous work identification control software systems approach utilises frequency sampling filter structure describe linear dynamics spline curve functions inverse static output nonlinearity furthermore issue parameter selection spline model approximation scatter data addressed using data clustering method experimental test bed virtualised software system established generate real observational data used confirm performance proposed approach identification results shown model efficacy increased proposed approach dimension nonlinear model significantly reduced maintaining desired accuracy
recent surge network performance put enormous pressure memory software processing subsystems argue primary reason high memory processing overheads inefficient use resources current commodity network interface cards nics propose flexnic flexible network dma interface used operating systems applications alike reduce packet processing overheads flexnic allows services install packet processing rules nic executes simple operations packets exchanging host memory thus proposal moves packet processing traditionally done software nic done flexibly high speed quantify potential benefits flexnic emulating proposed flexnic functionality existing hardware software show significant gains application performance possible terms latency throughput several widely used applications including key value store stream processing system intrusion detection system
paper studies estimation frictional torque synchromesh gear shifting operation electric vehicle equipped clutchless automated manual transmission amt clutchless drivetrain electric vehicle discussed dynamical model powertrain electric traction motor synchromesh system two speed amt developed order estimate frictional torque synchromesh indeed unknown input dynamical system assumed generated fictitious autonomous system thereafter augmented state space representation actual fictitious state variables forms basis observer design provided observability augmented system discussed deterministic luenberger observer stochastic kalman bucy filter designed order estimate frictional torque synchromesh estimation based measuring angular velocities electric motor synchro ring together known electromagnetic torque traction motor performance observers assessed experimentally means test rig results demonstrate satisfactory performance stochastic observer system encounters process measurement noise likely happen practice
breakthrough performances achieved computer vision utilizing deep neural networks paper propose use random forest classify image representations obtained concatenating multiple layers learned features deep convolutional neural networks scene classification specifically first use deep convolutional neural networks pre trained large scale image database places extract features scene images concatenate multiple layers features deep neural networks image representations use random forest classifier scene classification moreover reduce feature redundancy image representations derived novel feature selection method selecting features suitable random forest classification extensive experiments conducted two benchmark datasets mit indoor uiuc sports obtained results demonstrated effectiveness proposed method contributions paper follows first extracting multiple layers deep neural networks explore information image contents determining categories second proposed novel feature selection method used reduce redundancy features obtained deep neural networks classification based random forest particular since deep learning methods used augment expert systems systems essentially training proposed framework general easily extended intelligent systems utilize deep learning methods proposed method provide potential way improving performances expert intelligent systems elsevier ltd rights reserved
among several promising new drug delivery systems liposomes represent advanced technology deliver active molecules site action present several formulations clinical use research liposome technology progressed conventional vesicles first generation liposomes second generation liposomes long circulating liposomes obtained modulating lipid composition size charge vesicle liposomes modified surfaces also developed using several molecules glycolipids sialic acid significant step development long circulating liposomes came inclusion synthetic polymer poly ethylene glycol peg liposome composition presence peg surface liposomal carrier shown extend blood circulation time reducing mononuclear phagocyte system uptake stealth liposomes technology resulted large number liposome formulations encapsulating active molecules high target efficiency activity synthetic modification terminal peg molecule stealth liposomes actively targeted monoclonal antibodies ligands review focuses stealth technology summarizes pre clinical clinical data relating principal liposome formulations also discusses emerging trends promising technology
silicon photo multipliers sipm regarded novel photo detectors replace conventional photo multiplier tubes pmts however breakdown voltage dependence ambient temperature results gain variation similar degrees severely limits application device experiments wide range operating temperature especially space missions experimental setup established investigate temperature bias voltage dependence gain multi pixel photon counter mppc gain breakdown voltage dependence operating temperature mppc approximated linear function similar behavior zener diode measured temperature coefficient breakdown voltage degrees according fact analog power supply based two zener diodes operational amplifier designed positive temperature coefficient measured temperature dependence designed power supply degrees different output voltages designed power supply bias mppc voltage temperature variation similar degrees gain variation mppc biased voltage reduced degrees degrees biased mppc designed power supply gain control detailed design performance analog power supply temperature range similar degrees degrees discussed paper
green roofs recognized worthy strategy making buildings environmental friendly sustainable remain lot key concerns limitations usage green roofs following different driving initiatives green roofs researchers passionately exploring ways cater deficiencies existing technologies research offered using theory inventive problems solving triz seeking developmental directions potential future dimensions green roofs technologies presented possible ways model green roofs related problems different triz tools demonstrating ways seek guidance triz database inventive principles breakthrough solution directions research adds value researchers working green roofs developments provides way reach breakthrough solutions beyond one personal limited knowledge expertise broadening horizon solution search triz elsevier rights reserved
objective paper propose exact closed form solution infinity optimization piezoelectric materials shunted inductive resistive passive electrical circuits realizing den hartog method imposes fixed points equal height receptance transfer function approximate parameters piezoelectric tuned vibration absorber calculated direct minimization maxima receptance method applied one degree freedom primary oscillator considering various values electromechanical coupling coefficients
psychopathy often linked disturbed reinforcement guided adaptation behavior clinical non clinical populations recent work suggests disturbances might due deficit actively using information guide changes behavior however much information actually used guide behavior difficult observe directly therefore used computational model estimate use information learning thirty six female subjects recruited based total scores psychopathic personality inventory ppi self report psychopathy list performed task involving simultaneous learning reward based social information bayesian reinforcement learning model used parameterize use source information learning subsequently used subscales ppi assess psychopathy related traits traits strongly related model parameters isolated formal variable selection procedure finally assessed covaried model parameters succeeded isolating key personality traits believed relevant psychopathy related model based descriptions subject behavior use reward history information negatively related levels trait anxiety fearlessness whereas use social advice decreased perceived ability manipulate others lack anxiety increased results corroborate previous findings suggesting sub optimal use different types information might implicated psychopathy also highlight importance considering potential computational modeling understand role latent variables weight people give various sources information goal directed behavior conducting research psychopathy related traits field forensic psychiatry
paper presents study similarities electrical hydraulic pressurized networks primary objective examine whether possible use electrical laboratory networks measuring voltage study leak region detection strategies measuring flow water distribution networks paper strategy used compare networks error domain model falsification previously developed methodology data interpretation combines engineering knowledge models data enhance decision making simulation results obtained part water supply network city lausanne compared analogous electric network electrical network simulated using resistors mimic pipes consequence electrical model linear resistance values obtained computing hydraulic resistance pipe given hazen williams equation compatibility two networks evaluated simulations three ways comparing flow predictions obtained simulating several leak scenarios comparing expected identifiability performance two networks comparing sensor placement configurations analyses show even though models varying characteristics underlying physical principles electrical model linear hydraulic model non linear results within generally accepted engineering limits similarity indicates measurements electrical laboratory networks potential illustrate efficiency adaptability leak detection methodologies full scale water supply pressurized hydraulic networks finally two electrical laboratory physical networks including electrical model part water network lausanne constructed used case studies illustrate adaptability elsevier ltd rights reserved
paper illustrate proposed method control combines outputs several individual controllers improve global control complex nonlinear plants first part paper illustrate proposed method consists two levels top level fuzzy system represents superior control designed adjusting behavior individual fuzzy controllers lower level test approach consider problem flight control requires several individual controllers also comparison performed hierarchical control strategy compared simple control approach using student test paper show proposed method outperforms conventional fuzzy control approach optimal design proposed control architecture genetic algorithm also applied tune parameters fuzzy systems optimal fashion elsevier rights reserved
paper presents systemic analysis steady state performance novel cascade boost converters based developed switching signal flow graph sfg method effects caused parasitic parameters considered general guidelines drawing switching sfg derivation steady state information provided applications examples proposed graphical analytical method shows advantages high convenience practicability cascade boost converters circuit simulation experimental results provided support theoretical analysis
recent years increasing interest developing new biologic treatments psoriasis ustekinumab interleukin inhibitor demonstrated real efficacy treatment psoriasis psoriatic arthritis aimed describe centre experience therapy included patients mean age years male female ratio moderate severe psoriasis followed months course study patients received ustekinumab per usual protocol psoriasis area severity index pasi dermatological life quality index dlqi scores measured months pasi primary endpoint significant improvement pasi dlqi scores seen first weeks plateau week patients achieved pasi pasi month experience ustekinumab treatment moderate severe psoriasis showed excellent results patients reaching primary endpoint pasi month studies needed determine long term efficacy safety
systematic review epidemiological evidence examined risk factors sleep disturbances among older adults searched pubmed database combining search terms targeting following domains prospective sleep aging identified relevant population based studies prospective sleep outcome data two studies utilized objective measures sleep disturbance six used pittsburgh sleep quality index psqi thirteen used insomnia symptoms sleep complaints outcome measure female gender depressed mood physical illness consistently identified risks future sleep disturbances less robust evidence implicated following potentially relevant predictors lower physical activity levels african american race lower economic status previous manual occupation widowhood marital quality loneliness perceived stress preclinical dementia long term benzodiazepine sedative use low testosterone levels inflammatory markers chronological age identified consistent independent predictor future sleep disturbances conclusion prospective studies identified female gender depressed mood physical illness general risk factors future sleep disturbances later life although specific physiological pathways yet established research needed determine precise mechanisms factors influence sleep time elsevier ltd rights reserved
movement data collected gps technologies increasingly common difficult visualize due overplotting occlusion movements displayed maps additional challenge extraction useful higher level information meetings derived raw movement data present design study movementslicer tool visualizing places visited behaviors individual actors also meetings multiple actors first present taxonomy visualizations movement data consider tasks support analyzing movement data especially meetings multiple actors argue gantt charts many advantages understanding movements meetings small groups moving entities present design gantt chart nest people within locations locations within people along vertical axis show time along horizontal axis rows gantt chart sorted activity level filtered using weighted adjacency matrix showing meetings people empty time intervals gantt chart automatically folded smoothly animated transitions yielding multi focal view case studies demonstrate utility prototype
many application fields social networks commerce content delivery networks constant production big amounts data geographically distributed sites need timely elaborated distributed computing frameworks hadoop based mapreduce paradigm used process big data exploiting computing power many cluster nodes interconnected high speed links unfortunately hadoop proved perform poorly mentioned scenario designed developed hadoop framework capable scheduling distributing hadoop tasks among geographically distant sites way optimizes overall job performance propose hierarchical approach top level entity exploiting information concerning data location capable producing smart schedule low level independent mapreduce sub jobs software prototype framework developed tests run prototype showed job scheduler makes good forecasts expected job execution time
congenital agenesis internal carotid artery rare anomaly intracranial circulation involved internal carotid artery territory maintained collateral circulation contralateral internal carotid artery anterior communicating artery vertebrobasilar system posterior communicating artery usually patients internal carotid artery agenesis asymptomatic due collateral circulation may present headache seizures transient ischemic attack aneurysms also reported associated entity computed tomography angiography magnetic resonance angiography digital subtraction angiography commonly used modalities make diagnosis unenhanced skull base computed tomography show absence carotid canal thus differentiating carotid hypoplasia report case right internal carotid artery agenesis discussion embryogenesis clinical presentation imaging findings
promising results recent treatment trials alzheimer disease becomes increasingly important distinguish early stages causes cognitive impairment however existing diagnostic methods either invasive lumbar punctures pet inaccurate magnetic resonance imaging mri study investigates potential neuropsychological testing npt specifically identify patients possible among sample patients mild cognitive impairment mci dementia various causes patients divided early stage late stage group according mini mental state examination mmse score labeled non patients based post mortem validated threshold ratio total tau beta amyloid cerebrospinal fluid csf total tau ratio ratio patients completed established consortium establish registry alzheimer disease neuropsychological assessment battery cerad nab test battery two additional newly developed neuropsychological tests recollection verbal comprehension aimed carving specific alzheimer typical deficits based test results underlying pathologically increased ratio predicted machine learning algorithm end algorithm trained case patients except one predict leave one validation total group patients could correctly identified non early group small general cognitive impairment classification accuracy increased npt thus seems capable discriminating patients patients cognitive impairment due neurodegenerative vascular causes high accuracy may used screening clinical routine drug studies especially early course disease
etiology underlying mechanisms transient osteoporosis hip toh pregnancy still unclear since systematic analyses exist results support hypothesis toh multifactorial disease associated immobility dental problems lack exercise childhood introduction pregnancy associated transient osteoporosis hip toh rare severe form osteoporosis may affect subgroup women last trimester pregnancy immediately postpartum common symptoms include acute pain hip due bone marrow edema even hip fractures exact underlining mechanisms disorder still unknown since published systematic analyses exist methods total toh patients toh patients could matched healthy controls according age region gravity aim retrospective case control study evaluate risk factors toh homogenous population women results baseline characteristics two study groups similar overall toh patients sustained hip fracture expectedly toh patients complained pain hip toh patients suffered frequently severe dental problems childhood performed less often sports puberty whereas frequency immobilization pregnancy threefold higher compared control group found significant increase toh risk patients dental problems childhood well patients lack exercise childhood conclusions results support hypothesis pregnancy associated toh multifactorial disease several individual factors may contribute hereby found significant associations immobility dental problems lack exercise childhood
humans detect whether athletes leading trailing based thin slices athletes nonverbal behavior presumably communicating interpreting status evolved highly beneficial humans goal present research examine evolutionary perspective nonverbal behavior sports first experiment investigated leading athletes rated higher dimensions related social status trailing athletes experiment showed perceivers rated leading athletes dominant proud confident trailing athletes without aware actual score second interested role head related versus body related information role dynamic versus static information experiment participants watched short videos basketball matches rated whether athletes leading trailing occluded either athletes faces athletes bodies showed faces bodies experiments showed scarce information sufficient differentiating leading trailing athletes even faces bodies occluded findings line ecological approaches person perception evolutionary accounts nonverbal behavior
field experience shown sub synchronous oscillation sso harmonic resonance happen due interaction wind energy conversion system wecs converter controller hvdc converter controller impact system impedance paper investigates operation control wecs employing full scale converter connected electrical network voltage source converter vsc based high voltage hvdc transmission system sso harmonic resonance observed depending control implementation collection bus side hvdc converter origin oscillations attributed propagation wecs resonance wecs full converter link interaction wecs link dynamics hvdc system active damping scheme proposed improve system performance active damping implemented offshore hvdc system installed purpose integrating two wind farms analysis time domain simulation results spectral analysis presented show effective application proposed active damping
novel digital envelope modulator envelope tracking radio frequency power amplifier presented paper proposed modulator consists parallel combination linear class switching class power amplifiers controlled digitally previous analog architectures requirements needed operational amplifier high current driving capability high bandwidth large output swing usually obtainable high overall static power dissipation digitally controlled power opamp presented provides aforementioned requirements also reduces power dissipation compared previous work furthermore digital control modulator makes adaptive input signal variations comparison conventional analog parallel hybrid envelope modulators digital processor modulator evaluated complementary metal oxide semiconductor technology overall power consumption digital processor around ghz clock frequency application designed digital class incorporated complete envelope modulator architecture overall efficiency modulator including digital processor power consumption around average dbm output power mhz input signal copyright john wiley sons ltd
background purpose obesity risk factor cause cardiovascular death despite inverse relationship overweight obesity better cardiovascular prognosis long term follow studies observed phenomenon described obesity paradox also found evident atrial fibrillation cohorts methods performed systematic review relationship body mass index major adverse outcomes atrial fibrillation patients moreover provided meta analysis non vitamin antagonist oral anticoagulants noacs trials results obesity paradox found cardiovascular death cause death subgroup analyses randomized trial cohorts however observational studies fail show relationship meta analysis noac trials significant obesity paradox found overweight obese patients reporting lower risk stroke systemic embolic event odds ratio confidence interval respectively major bleeding obese patients lower risk compared normal weight patients significant treatment effect noacs found normal weight patients stroke systemic embolic event major bleeding major bleeding risk lower overweight patients treated noacs conclusions may obesity paradox atrial fibrillation patients particularly cause cardiovascular death outcomes obesity paradox also evident stroke systemic embolic event outcome noac trials treatment effect favoring noacs warfarin efficacy safety significant normal weight patients
objective thoracolumbar kyphotic deformity common complication late stage ankylosing spondylitis aim study compare correction efficacy ankylosing spondylitis kyphosis using preoperative osteotomy designs papercut splice photoshop methods retrospective study patients ankylosing spondylitis thoracolumbar kyphotic deformity underwent correction osteotomy department spinal surgery affiliated hospital yan university may november preoperative osteotomy design using splice applied patients preoperative osteotomy design using applied patients patients followed months postoperative osteotomy angle error correction efficacy last follow compared two groups results significant differences errors postoperative actual preoperative planned osteotomy angle group splice group spinal sagittal global kyphosis sagittal vertical axis group degrees respectively splice group degrees respectively oswestry disability index scoliosis research society srs questionnaire score group significantly higher splice group independently associated improvements srs scores conclusion compared osteotomy design using traditional splice osteotomy design using software could achieve smaller osteotomy angle error better postoperative spinal balance sagittal plane
background topical immunomodulators including corticosteroids calcineurin inhibitors vitamin analogues commonly prescribed multiple specialties cost comparisons lacking objective evaluate differences costs across specialties determine associated variables methods cross sectional study performed using centers medicare medicaid services prescription drug public use profiles contain drug claims made medicare beneficiaries results branded drugs cost average generics per day supply differences health insurance benefit phase drug choice brand name coverage type greatest determinants patient cost prescriptions low medium high potency specialists mostly dermatologists cost family medicine internal medicine psychiatry neurology physicians total costs day supply specialist differed family internal medicine physicians patient costs higher specialists brand names prescribed time specialists nonspecialists limitations unable adjust confounders cost medication weight treated body area data reflect previous treatment failures use non medicare patients conclusion costs tis prescribed specialists primarily dermatologists higher prescribed primary care physicians could reduced choosing generics within respective potency classes
rise fall artificial neural networks well documented scientific literature computer science computational chemistry yet almost two decades later seeing resurgence interest deep learning machine learning algorithm based multilayer neural networks within last years seen transformative impact deep learning many domains particularly speech recognition computer vision extent majority expert practitioners field regularly eschewing prior established models favor deep learning models review provide introductory overview theory deep neural networks unique properties distinguish traditional machine learning algorithms used cheminformatics providing overview variety emerging applications deep neural networks highlight ubiquity broad applicability wide range challenges field including quantitative structure activity relationship virtual screening protein structure prediction quantum chemistry materials design property prediction reviewing performance deep neural networks observed consistent outperformance non neural networks state art models across disparate research topics deep neural network based models often exceeded glass ceiling expectations respective tasks coupled maturity gpu accelerated computing training deep neural networks exponential growth chemical data train networks anticipate deep learning algorithms valuable tool computational chemistry wiley periodicals inc
objective study reports six year follow data patients borderline personality disorder bpd participated ulleval personality project upp randomized clinical study comparing outpatient individual psychotherapy oip long term combination programme comprising short term day hospital treatment followed outpatient combined group individual psychotherapy methods patients outcomes evaluated months months years years based wide range clinical measures symptom severity psychosocial functioning personality functioning axis diagnoses results six year follow patients condition reported significantly greater reduction symptom distress improvements personality functioning domains identity integration self control compared patients allocated oip patients also favourable long term course psychosocial functioning differences treatment conditions outcomes interpersonal functioning self esteem conclusions long term psychotherapy combination programme seems favourable bpd patients study patients received combined treatment fared better crucial parameters patients received individual therapy particular importance positive effects fundamental borderline problem areas like identity integration self control
paper introduces real logic framework seamlessly integrates logical deductive reasoning efficient data driven relational learning real logic based full first order language terms interpreted dimensional feature vectors predicates interpreted fuzzy sets real logic possible formally define following two tasks learning data presence logical constraints reasoning formulas exploiting concrete data implement real logic deep learning architecture called logic tensor networks based google tensorflow primitives paper concludes experiments simple representative example knowledge completion
objective interest continues neuropsychological measures cross disorder intermediate phenotypes understanding psychopathology central question concerns specificity versus generalizability particular forms psychopathology particularly executive functioning response speed three conceptual models examining relationships tested clarify picture different levels diagnostic hierarchy method participants total age yielded complete structured diagnostic interviews neuropsychological test battery comprising measures executive function processing speed repeated measures multivariate analysis variance linear regression structural equation modeling sem used test specificity model proposes individual disorders associated component processes speed severity model proposes total number comorbid disorders explain poor slow speed higher order dimensional model proposes internalizing versus externalizing disorders differentially related speed results effects best explained specificity model distinct aspects related attention deficit hyperactivity disorder versus antisocial substance use disorders speed hand emerged general indicator externalizing psychopathology dimensional model well overall severity psychopathology severity model conclusions granular approaches likely productive linking psychopathology whereas response speed underused potential endophenotype psychopathology liability results discussed terms integrated conceptualization neuropsychological processes putative neural systems involved general specific aspects psychopathology
wind energy become one cost effective renewable sources nowadays however stochastic nature associated wind energy production represents great challenge power system operations therefore probabilistic techniques necessary evaluate performance power systems substantial amounts wind generation paper presents probabilistic based level optimization approach evaluating impact wind farm location control strategy penetration level wind farms electricity market prices level optimization model formulated mathematical program equilibrium constraints mpec solved means nlpec solver general algebraic modeling system gams environment several cases studies presented paper determine optimal wind generation penetration market prices different locations control strategies wind farms moreover scenarios discussed regards practical allocation wind farms crown copyright published elsevier ltd rights reserved
strengths difficulties questionnaire sdq widely used psychopathology screening tool measures children emotional symptoms peer problems conduct problems hyperactivity inattention prosocial behavior previous psychometric studies sdq focused primarily older children western cultures suffered several methodological limitations study examined reliability factor structure convergent discriminant validity sdq focusing young asian american children using rigorous methods five factor structure sdq confirmed confirmatory factor analysis coefficients indicated adequate reliability subscales except parent rated peer problems conduct problems correlated trait correlated method minus one multitrait multimethod model provided evidence convergent validity discriminant validity subscales except conduct problems relative hyperactivity inattention study provided new evidence psychometric properties sdq young children cultural suitability sdq asian americans
objective test hypotheses children autism spectrum disorder asd higher screen time children nationally representative sample children asd overrepresented among children exceed american academy pediatrics aap screen time recommendation hours less day methods national survey children health nationally representative survey asked parents report child aged years average daily media usage asd subpopulation compared children without asd non asd differences compared design corrected tests regression models estimated groups separately adjusted wald tests used rigorously test hypotheses results half children exceed aap screen time recommendation compared non asd children asd similar amounts total screen time hours per day hours per day media video time computer mobile device leisure time children asd milder age gradient general population computer mobile device usage children asd proportionally represented among high users hours per day data support hypotheses conclusions large nationally representative sample evidence children asd differ screen time habits children groups high screen time use caution exercised assuming children asd higher risk exceeding aap screen time recommendations efforts promote adherence recommendation needed neither target exclude children asd
total number years old women republic kazakhstan frequency use hormone replacement therapy hrt drugs tend increase remains low level amounting frequency hrt drugs use among women obstetricians gynecologists different regions kazakhstan ages years old reasons low use hrt among obstetricians gynecologists associated fear cancer obesity thromboembolism stroke moreover information supported doctors especially oncologists endocrinologists low use different types contraceptives prevention unwanted pregnancy thus contraceptives used women reproductive age frequency use hormonal contraceptives remains extremely low levels slight increase resulted fact abortion remains primary birth control method low use hormonal contraception methods hrt drugs indicates hormonophobia among doctors specializations need increase knowledge obstetrician gynecologists internists cardiologists endocrinologists urologists healthy living office employees urban clinics modern methods contraception nosotropic therapy menopausal symptoms use hrt drugs
vibration measurement rotating machines important procedure identification malfunctions prevention failure case due difficulties mounting sensors rotating parts non contacting measurement methods usually employed interferometry vibrometry proximity sensing photogrammetry work focuses development low cost image acquisition system capable measuring dynamic behavior rotor shaft lateral vibration using photographic images full field measurement proposed method based sub sampling techniques reconstruction vibration signal measuring long acquisition periods suitable structures machines whose vibrating frequencies known rotating machines image acquisition vibration specific points interest shaft obtained adopting suitable image processing technique experimental tests performed rotating system flexible shaft driven electric motor controlled frequency inverter frequency range rpm rpm shaft vibration measurements compared measurements obtained proximity sensors good agreement observed even small vibration amplitudes
electrical arcs emit extremely high intensity light across wide spectrum damage eye delicate structures cornea retina developing industry safety standards mitigate light hazards critical component arc flash safety accurate measurement light intensity first step understanding level eye protection needed traditionally light measurement devices assembly light detecting resistors made cadmium sulfide cds silicon cells however response times inadequate capturing peak light intensity dynamic changes initial arc flash addition brightness arc flash greater measurable light levels traditional light measurement devices furthermore light sensitivity traditional sensors match commission internationale eclairage cie luminosity function lambda curve defines human eye sensitivity bright light function wavelength typical ambient light conditions paper discusses novel light measurement technique overcome limitations traditional approaches design capable measuring light intensity arc flash perceived human eyes results used evaluate potential arc flash harm eyes
objectivesinterpersonal dysfunction central borderline personality disorder bpd recent research focused role oxytocin bpd particularly regarding associations activity symptoms genetic polymorphisms oxytocin receptor coding gene oxtr bpd experimental modification interpersonal core problems patients bpd hypervigilance towards threat detection mistrust non verbal behaviour social interaction intranasal application methodsa literature medline review performed using keywords oxytocin borderline personality disorder secondary literature trauma attachment relation also considered relevant resultstogether findings suggest bpd associated enhanced defensive mechanisms avoidance behaviour moreover gene environment interaction concerning polymorphic variations oxtr gene childhood adversity bpd suggests genes convey developmental flexibility differential susceptibility environmental contingencies whereby bpd resides poor outcome end spectrum conclusionsin view conflicting literature needs studied carefully whether serve therapeutic agent given adjunct psychotherapy bpd research role also required regard prevention non genetic intergenerational transmission bpd clarifying role bpd may also benefit research non human animals targeting interaction early adversity availability directly practitioner points study oxytocin contribute understanding neurobiology borderline personality disorder oxytocin critically involved attachment security methylation oxytocin receptor may play role epigenetic modulation early adversity intranasal application oxytocin may useful therapeutic adjunct psychotherapy insecure attachment childhood adversity may produce differential neurobiological effects oxytocinergic system borderline personality disorder insufficient knowledge oxytocin interacts vasopressin testosterone dopamine serotonin also important key players experience social reward stress responsivity unclear whether oxytocin could beneficial preventing intergenerational non genetic transmission borderline personality traits
senescent cells accumulate variety tissues aging develop senescence associated secretory phenotype sasp entails secretion inflammatory cytokines chemokines proteases growth factors sasp components alter microenvironment within tissues affect function neighboring cells eventually lead local systemic dysfunction jak pathway highly activate senescent non senescent cells inhibition jak pathway suppresses sasp senescent cells alleviates age related tissue dysfunction targeting senescent cells could promising way improve healthspan aged population elsevier ltd rights reserved
modern competitive shooting strenuous test human perceptual motor systems like driving race car piloting high performance aircraft speed shooting matches require precise rapid movements coordinated using careful mixture planning reaction disciplines competitive shooting mixture complicated complex moving targets paper develops set state space equations moving reactive steel target used professional gun competition equations target motion nonlinear time varying chaotic certain regions state space derived equations target motion validated motion extracted video calibrated equations implemented real time portable laser activated simulator applications simulation environment marksmanship training human motor control studies also discussed
introduction etiologies intertrigo adults numerous different objective work study epidemiological clinical risk factors intertrigo adults methods conducted prospective study period seven months two dermatology units dakar senegal adults patient intertrigo seen period gave consent included results one hundred three patients intertrigo diagnosed hospital prevalence sex ratio average age study habits lifestyles patients found history intensive skin lightening sport wearing synthetic clothes smoking cases respectively infectious complications mainly bacterial viral reported nine cases dry erythroderma noted cases found intertigo commonly caused fungal infections prevalence followed immuno allergic reactions prevalence suppurative hidradenitis inverse psoriasis prevalence fifty eight percent cases tinea cases candidiasis women thirty five percent tinea cases candidiasis cases found history intensive skin lightening conclusion cause intertrigo adults mainly infectious particularly fungi infections immuno allergic diseases predisposing factors professions risk elsevier masson sas rights reserved
varied spatial resolution isochromatic fringes domain influences accuracy fringe order estimation using tfp rgb photoelasticity brought first part work existing scanning schemes take account leads propagation noise low spatial resolution zones paper method proposed creating whole field map represents spatial resolution isochromatic fringe pattern novel scanning scheme proposed whose progression guided spatial resolution fringes isochromatic image efficacy scanning scheme demonstrated using three problems inclined crack biaxial loading thick ring subjected internal pressure stress frozen specimen aerospace component proposed scheme use range applications scanning scheme effective even model random zones noise demonstrated using plate subjected concentrated load aspect well utilised extract fringe data thin slices cut stereo lithographic model characteristic random noise due layered manufacturing elsevier ltd rights reserved
paper presents innovative variable regulated high voltage power supply vrhvps output voltage ranging maximum current consists switched mode power supply smps followed linear regulator power supply rejection ratio pssr digital control module consists bit microcontroller small digital display isolated inter integrated circuit interface isolated hall sensor current sensor bit analog digital converters adc read output voltage current also bit digital analog converter dac controls linear regulator output voltage
paper proposes streamlined method model analyze assess overall performance small mobile machines move along large parts perform required machining operations conventionally called portable machines method based virtualization techniques combines process force mechanistic model reduced machine stiffness model synthesized virtual experimental reduced models subsystems model used assess improve performance portable machines examining time domain response tool center point representative operations rather limiting study frequency domain practical application particular portable machine presented used conduct presentation work results analysis accuracy use portable machines studied procedure also proves useful tool optimize machine design fit particular applications method experimentally evaluated conventional three axis milling machine ensure accuracy simulations elsevier ltd rights reserved
background objective study assess clinical computed tomography outcomes least years humeral head resurfacing treat concentric gleno humeral osteoarthritis hypothesis humeral head resurfacing provides similar outcomes achieved stemmed humeral head implants materials methods single centre retrospective study included copelandtm aequalistm humeral resurfacing heads implanted mean patient age diagnosis years diagnoses osteoarthritis intact torn rotator cuff avascular necrosis osteoarthritis complicating chronic instability post traumatic osteoarthritis chronic inflammatory joint disease validated clinical scores radiographs surgery last follow compared results mean follow months complications occurred implants revision surgery reverse shoulder replacement required cases mean months treat glenoid wear rotator cuff tear last follow implants require revision surgery mean constant score implants mean varus mean retroversion mean increase glenoid cavity depth mean increases medial lateral humeral offset respectively pre operative factors significantly associated failure rotator cuff tear glenoid erosion discussion found high failure rate related glenoid wear progressive rotator cuff impairment although showed evidence implant malposition overstuffing previous studies stemmed humeral head implants showed better outcomes given low medium term prosthesis survival rate reserve humeral head resurfacing concentric osteoarthritis without glenoid erosions rotator cuff damage published elsevier masson sas
optical pure lactic acid useful chiral intermediate synthesis chiral drugs materials engineering purpose environmental friendly high stereoselectivity enzymes used resolve racemic mixtures study cloned expressed haloacid dehalogenase thermophilic archaea sulfolobus tokodaii escherichia coli recombinant enzyme purified single band using heat treatment nta affinity chromatography optimum temperature value degrees respectively specific activity purified hydrolysis chloropropionic acid high enatioselectivity chloropropionic acid hydrolyzed produce lactic acid reaction optimization best conditions produce lactic acid temperature degrees mol buffer mol chloropropionic acid
urgent need policies close existing financing gap civil infrastructure however identification desired scenarios closure financing gap complex many factors affect investment infrastructure thus comprehensive models required simulate impacts policies identify highly likely scenarios desired policy outcomes objective paper create simulation model ante analysis financing policies highway transportation infrastructure united states using agent based technique model simulates microbehaviors state departments transportation private institutional investors public using output simulation model financing landscapes transportation infrastructure developed simulated landscape shown helpful identifying highly likely scenarios leading high level investment highway transportation infrastructure existing infrastructure investment structures budget constraints united states study presented paper novel respect application system systems modeling analysis transportation infrastructure financing policies identification desired policy scenarios likelihoods closure financing gap presence uncertainties adaptive behaviors simulation visualization impacts financing policies state national levels model promotes data driven policy analysis provides policymakers tool simultaneously account impacts several factors uncertainties american society civil engineers
aim investigate impulsive behaviors pathological buying methods study included three groups matched age gender treatment seeking outpatients treatment seeking psychiatric inpatients without healthy control group assessed means compulsive buying scale impulse control disorder icd module research version structured clinical interview dsm scid icd participants answered questionnaires concerning symptoms borderline personality disorder self harming behaviors binge eating symptoms attention deficit hyperactivity disorder adhd addition comorbid icds assessed using scid icd results groups differ regard borderline personality disorder adhd symptoms groups reported significantly symptoms group frequencies self harming behaviors differ three groups patients often diagnosed current icd excluding compared without group respectively discussion findings confirm prior research suggesting impulsive behaviors patients without compared healthy controls results questionnaire based assessment indicate outpatients perceive equally impulsive self harm frequently inpatients without seem suffer often icd assessed means interview
interest power gas energy storage technology increasing since allows utilise existing natural gas infrastructure storage medium reduces capital investments facilitates deployment systems using renewable electricity also substitute fossil fuels used heating transport study techno economic life cycle assessment lca applied determine key performance indicators systems generating hydrogen methane synthetic natural gas sng main products proposed scenarios assume systems participate swiss wholesale electricity market include several value adding services addition generation low fossil carbon gas find none systems compete economically conventional gas production systems selling hydrogen sng systems producing hydrogen four services heat oxygen supply needed ensure economic viability system captured air adds extra levelised cost sng compared supplied biogas upgrading plants offer economic case yet regardless number services environmental performance input clean renewable electricity electrolysis result environmental benefits compared conventional gas production particular life cycle environmental burdens dominated electricity supply electrolysis hydrogen production source case sng elsevier ltd rights reserved
purpose mirabegron beta adrenoreceptor agonist new molecule mechanism action distinct antimuscarinics combination therapy solifenacin recently studied adult population evaluated efficacy safety mirabegron add therapy treat urinary incontinence children idiopathic overactive bladder refractory intolerant antimuscarinics materials methods prospective label study using add regimens mirabegron conducted pediatric patients presenting symptom improvement undergoing intensive behavioral medical therapies significant side effects undergoing antimuscarinic dose escalation primary outcome better reported efficacy use prior antimuscarinic monotherapy secondary end points tolerability safety satisfaction efficacy tolerability assessed based voiding diaries post void residuals urine cultures electrocardiograms vital signs families questioned regarding continence side effects compliance wilcoxon signed rank test used statistical analysis results total patients recruited median age years administered add mirabegron median months median bladder capacity improved expected bladder capacity continence improved patients completely dry post void residual increased patients urinary tract infection reported seven patients reported mild moderate side effects withdrawals side effects patient post void residual conclusions add mirabegron appears safe alternative children refractory overactive bladder dual therapy well tolerated adjusted dose regimen appears safe first pediatric study
larvae insect galleria mellonella increasingly used studying pathogenic microbes virulence mechanisms rapid model screening novel antimicrobial agents larvae waxworms frequently infected injection pathogenic organisms haemocoel insect prolegs mostly widely used method restraining waxworms injection grasping operator fingers puts operator risk needle stick injury important consideration working highly pathogenic drug resistant microorganisms use stab proof glove reduce risk injury loss manual dexterity speed resulting labor intensive cumbersome assay describe simple cost effective device called galleria grabber restraining waxworms injection keeps operator fingers clear needle thus reducing risk injury
geoscience gives insights surroundings benefits many aspects life nowadays massive sensors deployed sense kinds parameters environments tens billions even trillions sensed data collected need analyzed surveillance purposes many perspectives users always issue queries according specific spatial temporal predicates applications relational databases overwhelmed large scale high rate insertions nosql database could considered feasible solution hbase popular key value store system capable solve storage problem fails provide built spatio temporal querying capability many previous works tackle problem designing schema designing row key column key formation hbase believe effective solution paper address problem nature level hbase propose index structure built component hbase stehix spatio temporal hbase index adapted two level architecture hbase suitable hbase process spatio temporal queries composed index meta table first level region index second level indexing inner structure hbase regions base structure two common queries range query knn query solved proposing algorithms respectively achieving load balancing scalable knn query two optimizations also presented implement stehix conduct experiments real dataset results show design outperforms previous work many aspects
measurement core losses electrical steel laminations considered essential step machine design process accordingly calibration tangential field sensor measurements magnetic field strength importance core loss measurements estimation electrical machine efficiency due stray field lamination surface tangential coil concern raised regarding certainty measured field paper presents reliable technical approach calibrate tangential field sensor used investigation core losses electrical machine laminations compensates drop actual field value proposed approach based developing magnetizing circuit consists two test laminations array hall effect sensors used study reference tangential field calibration results show magnetic field strength measured specimen surface tangential coil scaled actual field results verified experimentally validated finite element simulations based obtained results correction factor applied pulsating rotational core losses attain accurate data
flexible universal domain decomposition parallel scheme proposed unconditionally stable finite difference time domain fdtd method leapfrog alternating direction implicit fdtd adi fdtd method employed eliminate restriction courant friedrichs lewy stability condition proposed domain decomposition parallel implementation leapfrog adi fdtd method flexible process allocation requires fewer data communications buffer region introduced decouple interactions neighboring subdomains time step electromagnetic simulations presented demonstrate applicability accuracy efficiency proposed method
children suggestibility influenced several factors memory age social desirability main objective study analyze factors associated degree suggestibility year old year old year old children suggestibility measure new scale based gudjonsson suggestibility scale developed gss gudjonsson results showed younger children suggestible older children higher degree social desirability associated stronger suggestibility responses smaller memory span related greater children suggestibility conclusions highlight memory social desirability analyzed carefully eyewitness accounts children considered
quantile residual lifetime models often concern survival analysis especially studying chronic irreversible disease like dementia past several decades residual life models studied extensively right censored survival data however methods suitable analyze length biased right censored data prevalent cohort sampling article propose nonparametric semiparametric model based procedures estimate quantile residual lifetime censored length biased data two test statistics established comparing quantile residual lifetimes two groups evaluated respectively ratio difference terms type error probabilities powers simulations conducted compare proposed method existing approaches real dementia data national alzheimer coordinating center used illustrate proposed estimation methods estimating quantile residual lifetimes dementia patients canadian journal statistics statistical society canada
last decade jatropha based bioenergy projects gotten significant attention solution various social economic environmental problems jatropha popularity stemmed different discourses real perceived scientific non scientific literature discourses positioned jatropha crop helpful producing biodiesel protecting sustainability reducing greenhouse gas emissions compared fossil fuels increasing local rural development creating jobs consequently many countries established national policies incentivized establishment jatropha bioenergy feedstock crop paper explore case jatropha bioenergy development yucatan mexico argue popular discourse around jatropha sustainability rural development tool flawed analyzing results semi structured interviews community members belonging region plantation scale jatropha projects introduced found projects many significant social sustainability benefits conclude case adding bioenergy projects help achieve social sustainability rural areas alone ensuring social sustainability bioenergy projects future policymaking processes comprehensive understanding rural socioeconomic problems projects promoted use bioenergy projects one many solutions local problems rather creating policies based popular discourses
objective determine cohort young patients suspected axial spondyloarthritis axspa prevalence lumbosacral transitional vertebra lstv association local bone marrow edema bme lumbar spine degeneration potential relationship mri findings clinical signs axspa materials methods baseline imaging studies clinical information patients spondyloarthritis caught early cohort back pain months years onset years used two independent readers assessed patients lstv radiography bme like degenerative changes mri patients without lstv compared regard prevalence mri findings results clinical assessment using chi squared test test results patients male mean age patients showed lstv without statistical significant difference patients without axspa local sacral bme present patients lstv absent patients without lstv visual analogue scale vas pain score spinal mobility assessments comparable conclusions lstv low clinical relevance early diagnosis axspa difference patients without lstv regarding prevalence axspa pain spinal mobility bme like pattern pseudoarticulation reach joints
background aims hereditary haemorrhagic telangiectasia characterized arterio venous malformations avm frequently involves liver without clinical symptoms may lead biliary ischaemia portal hypertension fatal high output heart failure indication liver transplantation controversial methods herein report case year old female patient double osler syndrome consisting hereditary haemorrhagic telangiectasia hht type hereditary angioedema diagnosed age years respectively results hereditary angioedema treated danazol several decades multiple hypoechogenic liver masses detected albeit danazol treatment replaced esterase inhibitor infusions hepatocellular carcinoma diagnosed age patient listed liver transplantation hht marked recurrent epistaxis age severe intestinal bleeding occurred age severe dyspnoea nyha class developed rapidly progressive high output cardiac failure diagnosed despite argon plasma coagulation control bleeding intestinal angiodysplasia treatment bevacizumab inhibit angiogenesis patient died severe gastrointestinal bleeding associated cardiogenic shock age transplanted conclusion indication list patient liver transplantation debated several times diagnosis hepatocellular carcinoma good general condition low meld score precise guidelines screening management patients hepatic hht need better defined
cancer support group studied intervention improve patient psychosocial well effectiveness support groups among asian breast cancer patients unclear received limited attention evidence effectiveness social cognitive processing theory underlies principles support groups advocates positive supportive social environment improve cognitive processing purpose paper present integrative review research evidence effectiveness cancer support groups asian patients empirical studies related support group among asian asian american patients published april reviewed studies selected asian pacific region western countries review includes qualitative study descriptive studies mixed method design experimental quasi experimental studies support group intervention activities include psycho educational program health education problem solving stress management studies support effectiveness support group alleviating psychological distress supporting quality life asian women overall limited research use effectiveness support groups asians cancer patients asia western countries without accounting asian immigrants overseas asian population expected grow billion cancer patients become diverse due global emigration rigorous studies examining effectiveness psychosocial intervention among transcultural cancer patients needed
coding image problem teenage girls new south wales australia percentage female students learn coding matriculation level compared male students historic lows higher school certificate hsc matriculation exam subject software design development candidature female total students total hsc cohort students female statistics quoted related traditional print literacy would uproar gender disparity yet relation important element digital literacy coding experiencing barely murmur final frontier digital literacy coding skill coding comes power create interaction communication information spaces future girls left misconceptions assumptions hyper masculine coding culture need know ada lovelace daughter renowned poet lord byron considered world first computer programmer cosmopolitan article declared computer programming valued career opportunity women need learn coding possible within peer group girls see coding nerdy boy thing inspired work girls code https girlswhocode com google made code https www madewithcode com set smash perceptions within year english classes year old girls english classes coding traditionally linked mathematics sciences often viewed boy subjects choosing english introduce concepts sought shatter stereotype aimed show coding like poetry thinking making ideas come life using techniques tools series nearpod www nearpod com questionnaires established prior knowledge provoked heated discussions students used interactive onenote sequence investigate intersections arts poetry coding including creating poems researching communication methods ranking digital technologies rely every day students explored coding derives rules logic especially happens investigated links poetry coding create computer games using mit powerful scratch programming language https scratch mit edu tested understanding poetry reflection activities involved playing games together collecting qualitative data efficacy surveys anecdotes observations designing developing debugging girls power change world
compared position sensor control sensorless control avoids lot defects caused position sensor time makes system stability stronger anti interference performance advantages meets control field requirements better future gradually become hotspot brushless motor control field rotor position detection critical research brush less motor sensorless control paper new type rotor position detection method proposed based principle mathematical model brush less motor analysis advantages disadvantages back emf principle zero detection method back emf superposition means combination method two rotor position detection method neither need delay degrees require depth filter hardware circuit also simple need compensate phase shift frequency detection signal three times fundamental wave frequency method detection signal easier detect motor running low speed expand applicable speed range electric motor paper analyzes principle commutation logic rotor position detection method come conclusion stagnation point three bemf superposition derivative commutation points stator windings uses method back emf zero crossings determine current conduction state simulation model brushless motor control system established matlab simulink uses speed current double close loop control result shows method correct feasible get right rotor position signal control motor commutation correctly method achieve control brush less motor without position sensor provide reference research
two ground based two airborne cloud seeding events trace chemistry field experiment conducted desert research institute dri payette river basin idaho simulated weather research forecasting wrf model large eddy simulation les mode grid spacing using recently developed wintertime silver iodide agi seeding parameterization wasp xue wasp wrf specifically modified simulate emissions agl indium oxide ino particles ground aircraft based generators associated interactions hydrometeors validations model results available observations soundings snowpack telemetry snotel data show wrf simulations reasonably capture dynamics thermodynamics precipitation patterns comparisons deposited concentrations model results observations analyses seeding effects agi seeding efficiencies show simulated mass concentrations inside snow similar observations ranging mostly high spatial correlations observations ground seeding cases similar lower airborne seeding similar simulated ratios range indicating ice nucleation agl particle dominates scavenging agl incorporating snow overall simulated seeding effect four cases increase precipitation les domain similar inferred observations entire experiment magnitude agi seeding efficiency one order higher airborne seeding cases similar compared ground seeding cases similar elsevier rights reserved
growing amount evidence suggests magnesium deficiency may play important role several clinical conditions concerning women health premenstrual syndrome dysmenorrhea postmenopausal symptoms number studies highlighted positive correlation magnesium administration relief prevention symptoms thus suggesting magnesium supplementation may represent viable treatment conditions despite amount evidence describing efficacy magnesium systematize data available pharmacological mechanism ion conditions herein review systematize available evidence use oral magnesium supplementation several gynecological conditions discuss pharmacological mechanisms characterize interventions picture emerges indicates magnesium supplementation effective prevention dysmenorrhea premenstrual syndrome menstrual migraine prevention climacteric symptoms
lng liquefied natural gas regasification process source cold exergy suitable recovered improve efficiency thermal power plants paper innovative power plant lng liquefied natural gas exergy utilisation capture proceeding flue gases presented characterised recovery lng cold exergy closed brayton cycle direct expansion expander coupled electrical generator moreover novel power plant configuration allows capture oxy fuel combustion system rankine cycle operates flue gases quasi critical conditions greatest advantage plant recoverable lng exergy used increase efficiency cbc closed brayton cycle direct expansion whereas power cycles found literature associate lng regasification capture part lng exergy used condensing flue gas subsequent capture result high efficiency power plant achieved exceeding almost zero greenhouse gas emissions elsevier ltd rights reserved
new tri tetraphenylethylene substituted phenylcarbazole derivatives exhibiting aggregation induced emission synthesized synthetic route including catalyzed suzuki buchwald hartwig coupling heck reactions results evaluation thermal optical electrochemical photo physical charge transporting properties synthesized derivatives presented compounds possess high thermal stabilities weight loss temperatures exceeding degrees synthesized compounds form glasses glass transition temperature ranging degrees maximum fluorescence intensity wavelengths range highest photoluminescence quantum yield observed solid sample triphenylvinyl phenylethenyl phenyl ethylcarbazole electron photoemission spectra films synthesized compounds revealed ionization potentials hole drift mobilities layers phenylcarbazole para substituted tri tetraphenylethylene moities reached moderate electric fields established time flight technique
females two times likely males develop generalized anxiety disorder gad steiner vesga lopez moreover clinical presentation gad different across genders one explanation differences may role cognitive biases involved gad genders present study used exogenous spatial cueing task examine gender differences attentional bias negative positive information individuals primary diagnosis gad males females differ attentional bias idiographically selected negative neutral words however women showed significantly larger attentional bias positive words men results suggest developing gender specific treatments gad could improve treatment response rates
water pollution organic materials metals one problems threaten humanity nowadays next decades morphological changes nile tilapia oreochromis niloticus fish liver gills also represent adaptation strategies maintain physiological functions assess acute chronic exposure chemicals found water sediments paper presents automatic system assessing water quality sharkia governorate egypt based microscopic images fish gills liver proposed system used fish gills liver hybrid biomarker order detect water pollution utilized case based reasoning cbr indicating degree water quality based different histopathological changes fish gills liver microscopic images various performance evaluation metrics namely retrieval accuracy receiver operating characteristic roc curves measure mean used order objectively indicate true performance system considering unbalanced data experimental results showed proposed hybrid biomarker cbr based system achieved water quality prediction accuracy using cosine distance similarity measure also outperformed svms lda classifiers tested microscopic images dataset elsevier rights reserved
purpose review study aims provide update current status pharmacological therapies early advanced stages axial spondyloarthritis axspa well late onset forms discuss need treat target strategies entity recent findings efficacy tnf inhibitors assessed randomized controlled trials axspa included patients non radiographic axspa according asas classification criteria role pathway therapeutic target ankylosing spondylitis focus phase iii studies secukinumab named measure measure proof concept study ustekinumab potential efficacy novel small molecules apremilast tofacitinib explored recent phase trials summary trials tnf inhibitors non radiographic axspa achieved primary endpoints resulted approval indication europe usa phase iii trials secukinumab demonstrated significant therapeutic benefit compared placebo resulting approval first non tnf biologic treatment food drug administration european medicines agency
study objectives many sleep disorders characterized increased motor activity sleep contrast studies motor activity physiological sleep largely lacking quantitatively investigated large range motor phenomena polysomnography physiological sleep design prospective polysomnographic investigation setting academic referral sleep laboratory participants one hundred healthy sleepers age strictly selected representative population sample two step screening procedure interventions measurements results polysomnography according american academy sleep medicine aasm standards performed quantitative normative values established periodic limb movements sleep plms high frequency leg movements hflm fragmentary myoclonus neck myoclonus rapid eye movement rem related electromyographic emg activity thirty six subjects plms index plms index percentile thirty three subjects hflm percentile four sequences night subjects percentile sleep nine subjects fulfilled aasm criteria excessive thirty five subjects percentile rem sleep rem sleep different emg activity measures mentalis flexor digitorum superficialis muscles calculated percentile phasic mentalis emg activity sec epochs according aasm recommendation tonic mentalis emg activity twenty five subjects exceeded recently proposed phasic mentalis cutoff none subjects exceeded tonic mentalis cutoff conclusion quantification motor phenomena basic prerequisite develop normative values first step toward precise description various motor phenomena present sleep rates motor events unexpectedly high even physiological sleep future use normative values research clinical routine essential
paper presents system identification control unmanned helicopter ducted fan plant unstable multi input multi output mimo system first four identification methods considered work two methods studied identification system set transfer functions relating different inputs outputs namely least square method factorization recursive least square method rls two methods state space identification method indeed classical subspace identification method observer kalman filter identification okid method used identify system state space representation analytical formulations methods well comparison performances based degree fitness presented special case system results show okid performs methods based result okid lqgi based controller velocities tracking controller proposed simulation results show excellent tracking performance
paper presents date magnetic material investigation overview magnetic materials used rotating electrical machines focus small medium sized high performance high efficiency permanent magnet induction motors different application scenarios investigated materials include silicon iron nickel iron cobaltiron lamination steels well soft magnetic composites amorphous magnetic materials technical focus magnetic properties iron losses well manufacturing influence required thermal treatments manufacturing process new loss flux density factor introduced compare magnetization curve iron losses different materials diagram aim paper give machine designer efficient material overview selection guide early machine design process index terms machines amorphous magnetic materials
introduced composition function highway network communication system hncs hncs model established based fault tree analysis method according provided impact assessment model influence highway electromechanical system network reliability analyzed subsequently system reliability hncs evaluated paper put forward strategies improving network system reliability highway electromechanical system providing technical support maintenance work highway network system electromechanical equipments
much understanding biological mechanisms underlie cellular functions migration differentiation force sensing garnered studying cells cultured two dimensional glass plastic surfaces however recently cell biology field come appreciate dissimilarity flat surfaces topographically complex three dimensional extracellular environments cells routinely operate vivo spurred substantial efforts towards development vitro biomimetic environments encouraged much cross disciplinary work among biologists material scientists tissue engineers move towards physiological culture systems studying fundamental cellular processes crucial define exactly factors operative microenvironments thus focus commentary identifying describing fundamental features cell culture systems influence cell structure adhesion mechanotransduction signaling response soluble factors turn regulate overall cellular function ways depart dramatically traditional culture formats additionally describe experimental scenarios culture particularly relevant highlight recent advances materials engineering studying cell biology discuss examples studying cells context provided insights would observed traditional systems
effects exposure violent video games automatic associations self investigated sample students playing violent video game doom led participants associate aggressive traits actions implicit association test addition self reported prior exposure violent video games predicted automatic aggressive self concept beyond self reported aggression results suggest playing violent video games lead automatic learning aggressive self views association professionals services adolescents published elsevier ltd rights reserved
investigate association basal testosterone levels outcome vitro fertilization ivf women diminished ovarian reserve dor complete clinical data first ivf cycles women dor retrospectively analyzed associations basal follicle stimulating hormone luteinizing hormone estradiol levels ovarian response ivf outcome studied basal levels significantly different pregnant non pregnant women however basal levels showed correlation controlled ovarian hyperstimulation parameters adjusting age association basal levels pregnancy rate significant adjusting impact factors using receiver operating characteristic roc analysis basal level nmol predicting pregnancy outcome sensitivity specificity women divided two groups based value although clinical characteristics ovarian stimulation parameters similar clinical pregnancy respectively implantation rates respectively significantly different low high level groups women dor basal level presented positive association pregnancy outcome ivf poor reproductive outcome observed women lower basal levels may due decreased implantation rate
biomarkers brain amyloidosis neurodegeneration synaptic dysfunction featured recent diagnostic criteria alzheimer disease several gaps knowledge however need filled adopted clinically aim article describe roadmap developed multidisciplinary task force rationally implement biomarkers italian memory clinics roadmap based framework comprising sequential phases identification leads potentially useful biomarkers development clinical assays clinical disease evaluation detection early stages definition operating characteristics relevant populations estimation reducing disease associated mortality morbidity disability roadmap devised identifying current evidence validity still missing evidence action needed collect missing evidence appropriate adaptation local country specific circumstances roadmap translated countries elsevier inc rights reserved
background ottawa ankle rules provide guidelines clinicians recommendation radiographic tests verify fractures patients ankle injuries use ottawa ankle rules emergency nurses suggested minimise unnecessary radiographic test requests reduce patients length stay emergency departments however findings studies area inconsistent design systematic review conducted synthesise accurate evidence available extent emergency nurses use ottawa ankle rules initiate radiographic tests improves healthcare outcomes patients ankle injuries data sources systematic review attempted identify relevant published unpublished studies english chinese databases ovid medline embase proquest health medical complete ebm reviews sportdiscus cinahl plus british nursing index scopus chinese biomedical literature database china journal net wanfang data national central library periodical literature system hyread digital dissertation consortium mednar google scholar review methods two reviewers independently assessed eligibility studies identified search based titles abstracts study met criteria inclusion inconclusive information available title abstract full text retrieved analysis methodological quality eligible studies assessed independently two reviewers results search databases sources yielded records eligibility full text articles assessed nine studies met inclusion criteria nine studies subjected narrative analysis five meta analysed studies investigated use refined ottawa ankle rules results indicated emergency nurses use refined ottawa ankle rules minimised unnecessary radiographic test requests reduced patients length stay emergency departments however use rules urgent care departments reduce unnecessary radiographic test requests patients length stay implementation refined ottawa ankle rules emergency nurses different backgrounds including nurse practitioners general emergency nurses found reduce patients length stay emergency departments conclusions results systematic review suggested nurse initiated radiographic test protocol introduced standard practice emergency departments elsevier ltd rights reserved
myeloproliferative neoplasms chronic myeloid cancers divided philadelphia positive chronic myeloid leukemia negative polycythemia vera essential thrombocythemia primary myelofibrosis pmf negative cases activating jak mpl mutation recently somatic mutations calreticulin gene calr detected jak mpl negative patients affected pmf frequent mutations carl gene type currently calr mutations evaluated sanger sequencing evaluation carl mutations increases diagnostic accuracy patients without molecular markers could represent new therapeutic target molecular drugs developed novel detection assay order identify type calr mutations pna directed pcr clamping seventy five patients affected myeloproliferative neoplasms seven controls examined direct dna sequencing pna directed pcr clamping assay resulted sensitive specific cheaper sanger sequencing could applied even laboratory equipped sophisticated analysis interestingly report case carrying type type mutations calr gene
gambling help services typically evaluate treatment outcomes using self reported responses measurements however gamblers conceptualisations prioritisations respect measurements may shift time thus changes self reported responses may always reflect true change individuals study investigated response shift self report measures psychological distress impairment help seeking problem gamblers used confirmatory factor analysis model data structures pre treatment post treatment findings indicated response shift occurred two items became less important one item became important measuring psychological distress measurement invariance achieved complete set items impairment findings provide depth understanding nature self report outcomes otherwise routinely collected data
nada protocol acclaimed rapidly expanding complementary form therapy suited treat individuals suffering dependencies pressure psychosocial emergencies psychiatric disorders study situation regard nada protocol inconsistent three main reasons inadequate research methodology limited comprehension mode action nada protocol well limited understanding nada protocol complementarity successive evaluation major studies research strategy derived future evaluating nada protocol arises research performed conditions according general standards care comparative effectiveness research study effectiveness instead efficacy alleged placebo sham techniques used controls rather validated well introduced forms therapy applied research approach integrate evolving acupressure within context nada protocol
paediatricians health professionals working young children need aware potential child abuse cause physical injuries fractures clinical experience serious case reviews research show maltreatment kept mind order investigations carried appropriate prevent harm whilst accidental fractures common fractures may also sentinel injury alerts professionals possibility child abuse presenting clinically detected occult injury imaging reasons investigating case suspected maltreatment health professional evaluating child fracture aware features raise suspicion abuse cause familiar current recommendations investigations article outlines current research concerning abusive fractures children offers guidance optimize radiological investigations avoid common pitfalls clinical practice
small ruminants sheep goats play predominant role economy million people provided meat milk skin wool fiber centuries animals undergo various kinds stressors physical nutritional chemical psychological heat stress among concerning present ever changing climatic scenario climate change serious long term challenge faced small ruminants owners worldwide results decreased growth reproduction production milk quantity quality well natural immunity making animals vulnerable diseases even death thus results great economic losses emphasizing necessity objectively assess animal welfare increasing demand animal products paralleled frequent hot climate serious threat agriculture sector ability sheep goats cope without harming welfare productive performance often overrated date little attention paid comprehensive detailed data adverse effect sheep goats therefore review discusses detail sheep goats behavioral physiological molecular cellular hematological biochemical immunological responses conditions addition review also presents adverse effects reproduction fertility milk quantity quality feed intake water consumption sheep goats finally review suggests various methods alleviation conclusion impairs productivity well sheep goats improved understanding impact small ruminants help developing management techniques alleviate highlighting need future researches sheep goats
assess liver stiffness using ultrasound point shear wave elastography swe children fontan operation eighteen children undergoing fontan operation prospectively enrolled eight swe measurements obtained right hepatic lobe surgery multiple postoperative time points temporally related inferior vena cava pressure ivc data collected medical records available changes mean liver shear wave speed sws assessed using mixed effect model post hoc tukey correction changes ivc pressure evaluated using wilcoxon signed rank test value less considered significant mean age enrolment months baseline mean liver sws normal increased days days five subjects returned mean days mean liver sws remained elevated mean ivc pressure increased mmhg baseline mmhg days post surgery fontan operation immediately chronically increases liver stiffness ivc pressure study provides evidence congestion key driver fontan associated liver disease aeuro cent fontan operation triggers immediate hepatic congestion marked liver stiffening aeuro cent congestion fibrosis drives early increased liver stiffness fontan patients aeuro cent hepatic congestion persists chronically months fontan operation aeuro cent congestion confounds shear wave elastography post fontan liver fibrosis biomarker
despite popularity gpus high performance scientific computing despite increasingly general purpose hardware capabilities use gpus network servers distributed systems poses significant challenges gpunet native gpu networking layer provides socket abstraction high level networking apis gpu programs use gpunet streamline development high performance distributed applications like gpu memory mapreduce new class low latency high throughput gpu native network services face verification server
million hearts initiative goal preventing million heart attacks strokes leading causes mortality several public health healthcare strategies american heart association american college cardiology support program cardiovascular risk reduction model developed million hearts center medicare medicaid services strategy assess value based payment approach toward reduction year predicted risk atherosclerotic cardiovascular disease ascvd implementing cardiovascular preventive strategies manage abcs aspirin therapy appropriate patients blood pressure control cholesterol management smoking cessation purpose special report describe development intended use million hearts longitudinal ascvd risk assessment tool million hearts tool reinforces builds acc aha guideline assessment cardiovascular risk allowing clinicians estimate baseline updated year ascvd risk estimates primary prevention patients adhering appropriate abcs time alone combination tool provides updated risk estimates based evidence high quality systematic reviews meta analyses abcs therapies novel approach personalized estimation benefits risk reducing therapies primary prevention may help target therapies provide greatest benefit serves basis center medicare medicaid services program designed evaluate million hearts cardiovascular risk reduction model
spatiotemporal occurrence patterns stcops represent subsets feature types whose instances frequently occurring space time spatiotemporal occurrences reflect spatiotemporal overlap relationships among two spatiotemporal instances spatial temporal dimensions stcops potentially used predict understand generation evolution different types interacting phenomena various scientific fields astronomy meteorology biology geosciences meaningful statistically significant data analysis scientific fields requires processing sufficiently large datasets due computationally expensive nature spatiotemporal operations required mining spatiotemporal occurrences increasingly difficult identify spatiotemporal occurrences discover stcops centralized system settings solution developed cloud based distributed mining system discovering stcops system uses accumulo column oriented non relational database management system backbone order efficiently mine stcops propose three data models managing trajectory based spatiotemporal data accumulo introduce memory join index structure join algorithm effectively performing spatiotemporal join operations spatiotemporal trajectories non relational databases lastly experiments artificial real life datasets evaluate performance proposed models stcop mining
donald trump republican nominee hillary clinton democratic nominee presidential election speculations trump resonates many americans widespread suppositions whether independent party identification people might vote hillary clinton present study using sample american adults investigated whether two ideological beliefs namely right wing authoritarianism rwa social dominance orientation sdo uniquely predicted trump support voting intentions clinton cognitive ability predictor rwa sdo also tested path analyses controlling political party identification revealed higher rwa sdo uniquely predicted favorable attitudes trump greater intentions vote trump lower intentions vote clinton lower cognitive ability predicted greater rwa sdo indirectly predicted favorable trump attitudes greater intentions vote trump lower intentions vote clinton elsevier ltd rights reserved
background antenatal stress associated adverse outcomes mothers children however little research conducted identify factors associated psychosocial stress pregnant women purpose study explored predictors psychosocial stress pregnancy methods convenience sample second trimester third trimester pregnant women recruited medical center southern taiwan data collected using demographic form pregnancy stress rating scale psrs edinburgh prenatal depression scale pittsburgh sleep quality index maternal fetal attachment scale interpersonal support evaluation list results results study found positive correlations psrs edinburgh prenatal depression scale maternal fetal attachment scale negative correlations psrs gravidity interpersonal support evaluation list higher pregnancy stress predicted depression lower social support maternal fetal attachment primigravid status together explained total variance conclusions implications practice depression social support maternal fetal attachment gravidity discrete predictive factors psychosocial stress pregnant women findings add existing knowledge factors associated prenatal stress future research include depression support model antenatal stress management
possibility manufacturing textured materials devices surface properties controlled design stage instead result machining processes chemical attacks key factor incorporation advanced functionalities wide set micro nano systems high precision additive manufacturing technologies based photopolymerization together use fractal models linked computer aided design tools allow precise definition final surface properties however polymeric master parts obtained commercial systems usually inadequate biomedical purposes limited strength size prevents many potential applications hand additive manufacturing technologies aimed production final parts normally based layer layer melting sintering ceramic metallic powders always provide required precision obtaining controlled micro structured surfaces high aspect ratio details towards desired degree precision performance lithography based ceramic manufacture remarkable option discuss present study presents development two different micro textured biodevices cell culture results show remarkable control surface topography ceramic parts possibility obtaining design controlled micro structured surfaces high aspect ratio micro metric details
despite great advances treatment acute leukemia renaissance current chemotherapy needs improved present study elucidates underlying mechanism new synthetic quinoline derivative mptb acute leukemia potential anticancer effect drug resistant cells caused mitotic arrest ultimately led apoptosis demonstrated novel microtubule depolymerizing agent effects oral administration showed relative potent anti leukemia activity vivo xenograft model investigation revealed triggered induction mitotic arrest followed mitochondrial membrane potential loss caspases cleavage activation jun terminal kinase jnk addition enhanced cytotoxicity sirolimus sirolimus resistant acute leukemic cells inhibition akt mtor pathway mcl protein expression also active glycoprotein overexpressing national cancer institute adriamycin resistant cells little susceptibility taken together potential oral mitotic drug adjunct treatment drug resistant cancer cells
project healthy choices self administered mail based prevention intervention developed women risk alcohol exposed pregnancy aep participants sent assessment study materials united states postal service article uses data larger study focuses women identified hispanic potential participants called response english spanish ads said could read write spanish given choice receiving intervention materials english spanish main objective present study evaluate differences outcomes function language intervention materials received participants acculturation levels prior study women risk aep month follow two thirds hispanic women reduced overall risk aep primarily practicing effective birth control outcomes similar reported previous project choices studies significantly women requested intervention materials english compared spanish reduced overall risk aep women high english cultural domain scores significantly less risk aep due effective contraception reduced overall risk aep compared project choices studies project healthy choices less intensive self administered freely available completed without visiting health care practitioner clinic
objective study aimed assess role tadalafil phosphodiesterase type inhibitor pde recovery lower urinary tract symptoms luts robot assisted radical prostatectomy rarp materials methods patients treated rarp october august enrolled retrospective study prospectively collected data patients retrospectively divided groups according postoperative treatment patients taking tadalafil twice weekly month months rarp patients taking tadalafil international prostate symptom score ipss overactive bladder symptom score oabss urinary continence assessed preoperatively days rarp months rarp results difference overall ipss score groups months ipss storage symptom scores significantly lower patients taking tadalafil patients taking tadalafil patients overactive bladder oab rarp differences total scores oabss seen patients taking tadalafil patients taking tadalafil hand non oab patients rarp months total scores oabss significantly lower patients taking tadalafil patients taking tadalafil differences rates surgery seen groups conclusion postoperative tadalafil treatment may temporarily effective recovery ipss storage symptom scores oabss
creutzfeldt jakob disease cjd human prion disease different etiologies determine spectrum tau pathologies cjd assessed phospho tau ptau immunoreactivities sporadic cjd cases including evaluation entorhinal cortex six hippocampal subregions twelve cases showed small tau immunoreactive neuritic profiles fifty two showed additional tau pathology medial temporal lobe compatible primary age related tauopathy part cases lower ptau immunoreactivity load entorhinal cortex compared subiculum dentate gyrus region hippocampus significantly different typical distribution braak staging cases showed widespread tau pathologies compatible features primary tauopathies gray matter type ageing related tau astrogliopathy artag prominent gray matter artag also observed two three additionally examined genetic cjd cases analysis cerebrospinal fluid revealed prominent increase total tau protein cases widespread tau pathology ptau level increased four correlated immunohistochemical observations showing less pathology anti ptau antibody compared anti ptau frequency tau pathologies unusually high sporadic cjd precisely relate prp deposition however pattern hippocampal tau pathology often deviates stages braak currently applied examination cerebrospinal fluid ptau level reliably reflect primary tauopathies part artag seen cjd brains
temporary closures polluted coastal waters shellfish harvesting protect human health also generate broad socioeconomic impacts rural fishing dependent communities improved understanding impacts could help coastal managers prioritize investments protect water quality mitigate effects coastal pollution using regression model monthly landings explore impact temporary closures commercial harvest soft shell clams mya arenaria machias bay region maine usa find economic losses significant depend heavily tidal activity size frequency timing closures nine year sample period temporary pollution closures contributed loss million forgone revenue dollars approximately total revenue closures linked combined sewer overflows machias wastewater system produce majority losses million largest occurring peak clamming season may august results highlight variability impacts closures information burden efficient management shellfish areas coastal waters strategically reducing pollution managers could limit public health risks avoid destabilizing harvesting revenue bolster resilience fishing communities authors published elsevier ltd open access article license http creativecommons org licenses
safety tolerability pharmacokinetics efficacy bexarotene novel retinoid receptor rxr selective retinoid evaluated japanese patients stage iib ivb relapsed refractory stage iia cutaneous cell lymphomas ctcl study conducted multicenter open label historically controlled single arm phase study bexarotene administrated daily dose weeks patients following evaluation safety tolerability weeks dose three patients eight patients initial dose met response criteria using modified severity weighted assessment tool mswat weeks discontinuation dose limiting toxic effects dlt present four patients dose two neutropenia one abnormal hepatic function one hypertriglyceridemia dlt observed patients received bexarotene patients common drug related adverse events included hypothyroidism hypercholesterolemia leukopenia neutropenia nasopharyngitis anemia treatment related grade included hypertriglyceridemia patients increased alanine aminotransferase increased aspartate aminotransferase dyslipidaemia leukopenia neutropenia patients one patients experienced grade hypertriglyceridemia patients discontinued bexarotene due study dose reduction suspension required bexarotene shown well tolerated daily effective japanese patients ctcl
purpose study explore health beliefs migrant farmworkers parents approaching interviewing sample population health clinic seek care children impossible plan implement care create health care delivery models without knowledge health beliefs understanding parental health beliefs vulnerable population migrant farmworkers assure informed approach health matters children also improving health care delivery providing culturally specific health care models collecting data locations historically proven generate trust respect supported objectives research study promoted direct engagement group often misunderstood marginalized twenty migrant farmworkers parents interviewed growing season largely agricultural setting weld county colorado associated variables phenomena determining health beliefs include parental decision making regarding children health maintenance injury prevention health care overarching theme emerged data pride healthy children major themes respect convenience inhibition suppression
boyer dermott james macleavy discuss rise fathers primary caregiving positions within united kingdom following recessions outline number key questions commentary consider aims piece within contemporary parenting culture negotiation gendered binaries care note intersectional understanding decisions families making regard combining work childcare timely
based time domain quality factor factor measurement principle proposed architecture potential integrated chip thanks proposed original reconfigurable structure main measurement error offset operational trans conductance amplifier ota used cancelled automatically measurement operation leading high accuracy factor measurement digital control circuit plays important role automatic passage two configurations designed peak detector comparator main advantages proposed time domain factor measurement lay possibility integrated next micro electro mechanical system mems resonator measured miniaturization whole measuring system well enhancement measurement performance guide design architecture theoretical analysis linking required accuracy given factor circuit parameters given paper proposed circuit designed simulated complementary metal oxide semiconductors cmos technology post layout simulation results show operating frequency reach khz accuracy
polycythemia vera essential thrombocythemia chronic myeloproliferative neoplasms associated thrombotic hemorrhagic complications increased risk transformation myelofibrosis acute myeloid leukemia main goal therapy aimed preventing vascular events leading cause morbidity mortality patients accordingly risk stratification basis deciding treat patient cytoreductive therapy european leukemianet developed series management recommendations front line second line therapy provide optimal treatment individual patient still controversy efficacy safety several modalities cytoreductive treatment long term diseases use antiplatelet therapy presence jakvf calr mutations patients related different thrombotic risks probably lead different therapeutic approaches near future hand near normal life expectancy patients makes careful analysis benefits risks associated treatment essential review provides current management strategy patients polycythemia vera elsevier inc rights reserved
article deals simulation power converter voltage source inverter sine filter repetitive control system designed existing power converter control system makes fourier transform output voltage inject harmonics opposite phase new proposed system based repetitive controller much simpler smaller cpu load higher harmonics elimination works perfect power converter produces output voltage less thd linear non linear load paper describes improved control system structure implementation matlab simulink environment advantages repetitive algorithm facing fourier transform harmonic compensation shown performance new control method shown simulation results algorithm carried language using matlab function block suitable implementation real time control systems
evidence shows music therapy aids symptom management improves quality life palliative medicine hospice patients majority previous studies addressed patient needs addressed needs family members primary purpose study understand family members perceptions music therapy experienced relative palliative medicine hospice patient self reported scales music therapist assessment change also investigated patients scored symptoms pain anxiety depression shortness breath mood music therapy sessions one family member present session assessed perceived effect patient pain anxiety depression shortness breath stress level restlessness comfort level mood quality life effect family member stress level quality life mood helpfulness music therapy session patient self studied recommendations future patient participation music therapy qualitative comments also solicited fifty family member patient dyads participated study family member perceptions positive responders indicating improvement self patient stress mood quality life rating session extremely helpful recommending music therapy sessions patient patients reported statistically significant improvement pain depression distress mood scores family members patients palliative medicine hospice settings reported immediate positive impact music therapy patient research needs conducted better understand benefits music therapy family members
introduction testosterone deficiency syndrome tds usually suspected basis signs symptoms however men low testosterone levels low asymptomatic present mild unnoticed symptoms would cardiovascular risk symptomatic men aims study aims assess relationship presence severity low related symptoms likelihood metabolic syndrome mets methods data taken multicenter cross sectional study conducted spain among men visiting men healthcare offices aged low total nmol nmol calculated free nmol subjects whose mets components symptoms assessed selected data available included anthropometrics toxic habits comorbidities total testosterone levels main outcome measures mets defined using harmonized definition erectile dysfunction classified using international index erectile function questionnaire ageing male symptoms ams scale assessed symptoms symptom severity classified none mild moderate severe bivariate multivariate logistic regression analyses performed calculate effect moderate severe symptoms odds ratio mets results mean age years erectile dysfunction ams mets prevalence prevalence mets higher men moderate severe symptoms men mild ones age prevalence nmol moderate severe obesity significantly higher men moderate severe symptoms multivariate analysis showed besides obesity moderate severe moderate severe symptoms increased likelihood mets effect disappeared men severe nonobese three symptoms showed relationship mets adjusting confounding factors conclusion severity tds symptoms may indicate higher cardiovascular risk men low garcia cruz leibar tamayo romero otero asiain carrion castaneda mateu luque cardenosa alcaraz marked testosterone deficiency related symptoms may associated higher metabolic risk men low testosterone levels sex med
examine degree party leaders dominate parties time across countries analyse leadership domination relates formal aspects party organisation moreover analyse whether antidotes leadership domination widening selectorate increasing membership explain change leadership domination purpose use new dataset brings together different sources party data time countries find leadership domination indeed increased time still lot variation exists parties also demonstrate widening selectorate example letting members elect party leader increasing membership boosts leadership domination words antidotes leadership domination work
oilseeds plant family brassicaceae important providing lipid protein contents human nutrition cruciferins globulins seed storage proteins getting attention due allergenic pathogenicity related nature study describes purification characterization trimeric similar kda cruciferin protein seeds brassica nigra cruciferin first partially purified ammonium sulfate precipitation saturation constant purified size exclusion chromatography terminal amino acid sequence analysis showed sequence homology cruciferin arabidopsis thaliana kda monomeric cruciferin produced multiple bands two major molecular weight ranges polypeptides kda beta polypeptides kda reduced conditions sds page gel electrophoretic analysis showed separation bands isoforms major ranges poly peptides beta polypeptides dynamic light scattering dls showed monodisperse nature cruciferin hydrodynamic radius confirming trimeric nature protein circular dichroism spectra showed helices beta sheets native conformation trimeric protein pure cruciferin protein successfully crystallized however crystals diffracted low resolution data small angle ray scattering saxs applied gain insights three dimensional structure solution saxs showed radius gyration confirmed nearly globular shape saxs based initio dummy model nigra cruciferin compared globulins pdb kgl napus confirmed highly similar molecular weight globular shape indicating conserved trimerization nigra cruciferin comparison scattering patterns proteins showed minimized value confirming similar molecular structure first report describing purification characterization cruciferin protein seeds nigra elsevier rights reserved
background prevention interventions people living hiv aids important component hiv programs report results pilot evaluation four hour clinic based training healthcare providers south africa hiv prevention assessments messages pre post pilot evaluation examined whether training associated providers delivering prevention messages methods seventy providers trained four public primary care clinics high volume hiv patients pre post training patient exit surveys conducted using audio computer assisted structured interviews seven provider appropriate messaging outcomes one summary provider outcome compared pre post training using poisson regression results four hundred fifty nine patients pre training post training known hiv status interviewed including hiv positive patients respectively among hiv positive patients delivery appropriate messages providers declined post training summary outcome decreased adjusted rate ratio sensitivity analyses adjusting training coverage time since training detected fewer declines among hiv negative patients summary score stable pre post training adjusted rate ratio conclusions surprisingly training associated decrease prevention messages delivered hiv positive patients providers limited training coverage delays training post training survey may partially account apparent decrease targeted approach prevention messages may effective
participants study study responded video person suffered mishap studies manipulated whether person responsible mishap degree consequences subsequently found serious results study showed reduction schadenfreude compassion victim serious condition due appraisals immoral laugh misfortune stronger appraisals stronger initial schadenfreude stronger moral emotions guilt shame regret initially expressed schadenfreude moral emotions compassion fostered prosocial behavior study extended results showing seriousness consequences acted moderator findings significant effects occurring serious condition reduction schadenfreude occurred consequences serious person less responsible misfortune studies extend past research investigating schadenfreude emotions context involve social comparison participants reflected initial expressions schadenfreude
aims main objective study define urinary biomarkers predict severity overactive bladder detect patients would benefit treatment methods patients oab diagnosis healthy controls included study bladder diary validated oab questionnaire given patients oab group solifenacin daily given month urine samples taken treatment first month treatment groups urinary bdnf ngf gag mcp levels measured results total oab patients healthy age matched controls included bdnf cre ngf cre mcp cre gag cre levels significantly higher oab group levels biomarkers significantly decreased month solifenacin treatment treatment patients oab symptoms relieved respond treatment although basal biomarker levels differ responder non responder groups ratio decrease biomarker levels significantly higher treatment sensitive patients postmenopausal women resistant treatment compared premenopausal group conclusions urinary biomarkers role pathophysiology oab however predict patients would benefit treatment antimuscarinics would useless future studies higher numbers patients different oab subgroups needed investigate exact role biomarkers wiley periodicals inc
study kinematic analysis dynamic analysis simulation control stewart platform linear motor presented using inverse kinematic method velocity acceleration equations derived lagrange newton euler equations used carry dynamic analysis especially dynamic analysis lower part leg inertia taken account required forces actuator calculated using matlab according planned trajectories moving platform dynamic simulation system presented without inertial effect lower part leg results dynamic simulation show effect lower part inertia leg important obtain accurate result pid control stewart platform performed using matlab simulink transfer function linear motor derived block diagram obtained simulink finally case studies performed verify developed control system
following wired network virtualization virtualization wireless networks becomes next step aiming provide network infrastructure providers ability manage control networks dynamic fashion benefit wireless mobile network virtualization agile business model virtual mobile network operators mnos request thus pay physical mnos pay use manner paper presents resource allocation algorithms joint network virtualization resource allocation wireless networks overall algorithm involves following two major processes firstly virtualize physical wireless network multiple slices representing virtual network secondly carry physical resource allocation within virtual network slice particular paper adopts orthogonal frequency division multiplexing ofdm physical layer achieve efficient resource utilization therefore resource allocation conducted terms sub carriers although motivation algorithm design based ieee wimax networks principle algorithmic essence also applicable ofdm access based wireless networks aim achieve following design goals virtual network isolation resource efficiency latter measured terms network throughput packet delivery ratio simulation results show aforementioned goals achieved copyright john wiley sons ltd
background auditory development children hearing loss including perception prosody depends adequate input cochlear implants hearing aids lack adequate auditory stimulation lead delayed speech language development nevertheless prosody perception production people hearing loss received less attention aspects language perception auditory information conveyed prosody using variations pitch amplitude duration speech usually evaluated clinically purpose study compared prosody perception production abilities children hearing loss children normal hearing investigated effect age hearing level musicality prosody perception research design participants children hearing loss typically developing controls matched age gender fifteen children hearing loss tested using amplification hearing aids cochlear implants six receptive subtests profiling elements prosody speech communication peps child paralanguage subtest diagnostic analysis nonverbal accuracy danva contour interval subtests montreal battery evaluation amusia mbea used audio recordings children reading samples rated using perceptual prosody rating scale nine experienced listeners blinded children hearing status study sample thirty two children hearing loss mean age age gender matched typically developing children normal hearing mean age data collection analysis assessments completed one session lasting hours quiet room test items presented using laptop computer loudspeaker comfortable listening level children hearing loss using hearing instruments tests completed hearing devices set everyday listening setting results peps subtests total scores significantly lower children hearing loss compared controls hearing loss group performed poorly control group recognizing happy sad fearful emotions danva subtest musicality composite mbea scores musical experience significantly correlated prosody perception scores link evident regression analyses regression modeling showed age hearing level better ear pure tone average accounted variance peps danva total scores respectively greater variability ratings pitch pitch variation impression prosody hearing loss group compared control group prosody perception peps danva total scores ratings prosody production correlated conclusions children hearing loss aged significant difficulties understanding different aspects prosody rated atypical prosody overall controls findings suggest clinical assessment speech language therapy services children hearing loss expanded target prosodic difficulties future studies investigate whether musical training beneficial improving receptive prosody skills
proportional integral derivative controllers used process industry control various complex industrial processes due simplicity easy implementation various structures pid controllers available literature makes difficult decide selection suitable controller structure particular industrial process model complexity increases case structures derivative filters matter investigation evaluate effect varying filter coefficient controller performance pid controller structures present analysis lay emphasis set point tracking capability controller weighting filter coefficients structures
paper proposes method finite element model updating civil structures method hybrid global optimization algorithm combining simulated annealing unscented kalman filter ukf objective function optimization problem defined modal time frequency domains algorithm improves accuracy convergence rate computational cost algorithm local improvements accepted candidates though ukf proposed methodology validated using mathematical function numerically simulated response data linear nonlinear models realistic three dimensional structures elsevier ltd rights reserved
previous studies reported translation effect memory whereby encoding tasks involve translating processing domains produce memory advantage relative tasks involve single domain investigated effects translation true false memories using deese roediger mcdermott drm procedure deese prediction occurrence particular verbal intrusions immediate recall journal experimental psychology roediger iii mcdermott creating false memories remembering words presented lists journal experimental psychology learning memory cognition translation modalities enhanced correct recognition effect false recognition results consistent previous research showing correct memory enhanced cost terms accuracy findings discussed terms understanding relationship true false memories produced drm procedure
cherries one appreciated summer fruits due attractive colour sweet taste high water content low level calories composition bioactive compounds turn important prevent pathologies like diabetes cardiovascular diseases cancer work evaluated phenolic profile biological potential varieties sweet cherries fundao region portugal saco sweetheart satin maring hedelfinger total phenolic compounds identified dad distributed several classes anthocyanins hydroxybenzoic acid hydroxycinnamic acids flavan ols flavonols maring revealed higher contents anthocyanins hedelfinger richest non coloured phenolics antioxidant capacity evaluated dpph nitric oxide radicals hedelfinger active dpph center dot mating nitric oxide afterwards antidiabetic capacity evaluated inhibition alpha glucosidase activity pointing hedelfinger active capacity saco extracts inhibit hemoglobin oxidation hemolysis human erythrocytes also evaluated assays revealed concentration dependent inhibitory effect respectively results obtained study allow conclude sweet cherries possess great biological potential investigation done promote commercialization encourage use food supplements new pharmaceutical nutraceutical applications published elsevier ltd
backgrounda item qualiveen questionnaire developed measure impact urinary problems everyday living spinal cord injury subsequently item qualiveen developed multiple sclerosis validity short form previously examined using modern psychometric techniques rasch measurement model objectivethe aim study test short form meets requirements rasch model methodsa total patients clinically definite given questionnaire three neuroscience centres resultsa total patients response completed questionnaire original scale failed meet expectations rasch model two testlet solution sought account local dependence differential item functioning disordered thresholds modifications made scale fitted model high internal consistency unidimensional conclusionssf qualiveen simple valid measure impact urinary problems multiple sclerosis meets requirements rasch measurement model summed ordinal scores converted interval level using transformation table provided
article outlines emergence aba applied behaviour analysis mid century current popularity aba anglophone world draw work earlier historians highlight role ole ivar lovaas influential practitioner aba argue reception initial work mainly positive despite concerns regarding efficacy use physical aversives lovaas work however cautiously accepted medical practitioners published results many accepted results validation lovaas research though methods broader understanding autism shifted considerably since early work article analyses controversies surrounding aba since early considering particular criticisms made autistic people neurodiversity movement earlier critics condemn use painful aversives exemplified campaign use shock therapy judge rotenberg center unlike earlier non autistic critics however many movement reject ideological goals aba considering autism harmless neurological difference rather pathology argue eliminating benign autistic behaviour aba impermissible owing individual psychological harm wider societal impact finally compare claims made neurodiversity movement made similar century social movements
objectivethis study tested new dsm severity criterion anorexia nervosa based proposed body mass index bmi cut points methodparticipants clinical sample treatment seeking patients diagnosed dsm portugal participants categorised based dsm severity levels compared demographic clinical variables assessed eating disorder examination questionnaire resultsbased dsm severity definitions participants categorised mild bmi moderate bmi severe bmi extreme bmi severity groups differ significantly age gender analyses comparing severity groups measures eating disorder psychopathology revealed significant differences eating disorder examination questionnaire global subscale scores groups also differ significantly frequency binge eating purging episodes within past days conclusionsour findings clinical sample patients portugal provide evidence new dsm severity ratings based bmi level research validity dsm specifiers needed test additional clinical functional variables especially prognostic utility course outcome across eating disorders copyright john wiley sons ltd eating disorders association
doppler lidars high pulse repetition frequency susceptible range ambiguities clouds distant targets large backscatter range ambiguities degrade quality wind profiles calculated retrieved variables technique detect remove range folded returns moment observations proposed described simplified method removing erroneous wind observations range folded returns also detailed detection removal range folded echoes quality accuracy wind profiles shown improve
abnormalities neural feedback processing systems may play role development dysfunctional behavior individuals diagnosed conduct disorder present study investigated relation adolescents feedback processing measuring event related potentials erps single outcome gambling task included reward valence loss gain reward magnitude cents outcomes components established effective indicators studies behavioral disinhibition reward processing decision making eighteen adolescent males age years diagnosed healthy age matched male controls recruited compared healthy controls individuals exhibited reduced amplitudes response loss condition also significant decreased amplitude conditions amplitudes negatively correlated impulsivity scores across groups amplitudes positively correlated impulsivity scores across groups findings suggest adolescents may impaired neural sensitivity feedback processing environmental cues compared healthy controls moreover may reliable indices detect different sensitivity reward punishment feedback processing elsevier rights reserved
memory increasingly understood source vulnerability resilience within experience disasters associated natural hazards article investigate members marginalised populations impacted disasters australia new zealand drew forms memory tied minority identity gay men along sexual gender minority groups experience increased vulnerability disaster contexts resulting discrimination stigmatisation draw interviews two gay men lived crisis hiv aids beginning recently seriously impacted disaster associated natural hazard memories hiv aids informed men experiences later disaster ways bolstered resilience conversely resulted feelings vulnerability isolation
recently bit level permutation strategy chaotic image cryptosystem studied extensively due pixel value mixing effect however efficiency cryptosystem suffers high computational complexity since chaotic state variables required shuffle bits rather pixels besides exists computational redundancy ciphering special images using conventional approaches promote efficiency novel bit level chaotic image cipher based lookup table proposed paper accordingly sequential addition operation introduced bit level permutation purpose reducing permutation redundancy moreover diffusion cross reverse manner also contributed speed acceleration hand plaintext related permutation mechanism implemented lookup table construction enhance security proposed cryptosystem simulation results analyses show proposed scheme efficient maintaining high security performance
global demand clean water supplies rise due population growth also true cities iran non conventional water resources must developed partially offset increasing demand study applicability performance rainwater harvesting rwh systems supply daily non potable water assessed storage rain falling roofs residential buildings directed installed tanks simulated three cities varying climatic conditions namely tabriz mediterranean climate rasht humid climate kerman arid climate daily rainfall statistics period years well information contributing roof area available tank volumes non potable water demand collected city typical residential buildings roof areas average four residents house considered study according results humid climate possible supply least non potable water demand storing rainwater larger roof areas maximum duration times roofs small surface area supply meets non potable water demand maximum duration times moreover mediterranean climate possible supply least non potable water demand buildings larger roof areas maximum duration times also found arid climate similar duration times elsevier rights reserved
study aimed correlating magnetic resonance index activity maria magnetic resonance enterography global score megs activity indexes paediatric population crohn disease retrospective study included paediatric patients median age years male proven underwent magnetic resonance enterography mre correlation analysis performed mre based scores simplified endoscopic score ses paediatric crohn disease activity index pcdai reactive protein crp levels based pcdai comparison global maria megs made patients mild moderate severe disease activity global maria correlated ses pcdai megs correlated pcdai crp levels megs differed significantly patients grouped clinical disease severity mre based global scores correlated clinical indexes activity therefore represent potential useful tool predict activity severity well possible promising alternative endoscopy monitor paediatric patients follow mre widely used accurate assessment global maria megs suggested indicators activity paediatric studies comparing mre based global scores clinical activity lacking scores serve predictors activity severity paediatric patients mre offers alternative clinical score endoscopy paediatric monitoring
presbyacusis age related hearing loss characterized humans metabolic sensory phenotypes based patterns audiometric thresholds established animal models metabolic phenotype thought result deterioration cochlear lateral wall reduced endocochlear potential decreases cochlear amplification produces mild flat hearing loss lower frequencies coupled gradually sloping hearing loss higher frequencies sensory phenotype resulting environmental exposures excessive noise ototoxic drugs involves damage sensory non sensory cells loss cochlear amplifier produces threshold shift higher frequencies mixed metabolic sensory phenotype exhibits mix lower frequency sloping hearing loss similar metabolic phenotype steep higher frequency hearing loss similar sensory phenotype current study examined audiograms collected longitudinally adults years old ears test hypothesis metabolic phenotypes increase increasing age contrast sensory phenotype quadratic discriminant analysis qda used classify audiograms ears older normal metabolic sensory metabolic sensory phenotypes although hearing loss increased systematically increasing age audiometric phenotypes remained stable majority ears average years participants stable phenotypes demonstrated matching phenotypes left right ears audiograms collected average period years ears changing audiometric phenotypes majority ears transitioned metabolic metabolic sensory phenotype results consistent conclusion likelihood metabolic presbyacusis increases increasing age middle older adulthood
complex paediatric neurology cpn patients generally present non specific symptoms developmental delay impaired movement epilepsy diagnostic trajectory disorders usually complicated long lasting may burdensome patients parents additionally caring chronically ill child stressful demanding parents patients may experience impaired health related quality life hrqol study aims assess parental hrqol factors related cpn physical mental hrqol parents measured compared general population using questionnaire parents also completed questionnaire measurement patient hrqol additional questionnaires used measure parental uncertainty visual analogue scale worry phenomena penn state worry questionnaire obtain socio demographic data linear mixed model random effect used investigate variables associated parental hrqol compared general population hrqol parents appeared diminished fathers showed lowered physical mental hrqol whereas mothers showed diminished mental hrqol patient hrqol parental worry phenomena significantly correlated overall mental parental hrqol reduction parental mental hrqol alarming also children strongly rely parents parental mental health known influence children health awareness problems among clinicians supportive care needed important prevent exacerbation problems european paediatric neurology society published elsevier ltd rights reserved
paper describe second order multi dimensional scheme belonging class direct arbitrary lagrangian eulerian ale methods solution nonlinear hyperbolic systems conservation law scheme constructed upon cell centered explicit lagrangian solver completed edge based upwinded formulation numerical fluxes computed muscl hancock method obtain full ale formulation numerical fluxes depend nodal grid velocities either set computed avoid mesh problems typically encountered purely lagrangian simulations order assess robustness scheme results proposed paper obtained computing grid velocities fraction lagrangian nodal velocities ratio set running test case last part paper describes preliminary results triple point test case run ale framework computing grid velocities fully adaptive large eddy limitation method proposed method automatically computes grid velocities node defining mesh local characteristics flow eventually discuss advantages drawback coupling elsevier inc rights reserved
exist numerous state art classification algorithms designed handle data nominal binary class labels sample belongs single class label problems known flat classification problems class labels independent unfortunately hand less attention given genre classification problems samples may belong several classes time class labels organized based structured hierarchy gene ontology protein function prediction test scores web page categorization text categorization etc article presents novel ant colony optimization based hierarchical multi label classification algorithm handle complex instance classification problems incorporates given class hierarchy learning phase algorithm produces ordered rule list learn comprehensible model easily verified experts exploits positive correlation domain values two related attributes improve discrimination power resultant classification model significant level paper contains rich details regarding hierarchical single label single path multi label classification problems different categories corresponding solutions proposed method evaluated sixteen challenging bioinformatics datasets containing hundreds attributes thousands class labels end proposed method compared four recent state art hierarchical multi label classification algorithms empirical evaluation confirms promising ability proposed technique hierarchical multi label classification task elsevier rights reserved
paper presents interval effective independence method optimal sensor placement contains uncertain structural information overcome lack insufficient statistic description uncertain parameters paper treats uncertainties non probability intervals based iterative process classical effective independence method proposed study considers eliminating steps uncertain cases therefore method fisher information matrix extended interval numbers could conform actual engineering long know bounds uncertainties interval fisher information matrix could obtained conveniently interval analysis technology moreover due definition calculation interval relationship possibilities eliminating candidate sensors iterative process final layout sensor placement presented paper finally two numerical examples including five storey shear structure truss structure proposed respectively paper compared monte carlo simulation indicate veracity interval effective independence method
study sought determine features ideal serve men professional tennis total first serves executed male tennis players australian open competition classified either aces returned play spatiotemporal impact location speed projection angles landing location relative player locations contextual score features serve extracted hawk eye data used construct classification tree model decision rules predicted serve outcome means clustering applied landing locations quantify optimal landing locations aces classification tree revealed serve directionality relative returner ball landing proximity nearest service box line serve speed classified aces accuracy hitting aces appeared contingent accuracy speed serves directed degrees returner landing service box line indicative ace means clustering revealed four distinct locations approximate widex deep corners service box corresponded aces landing locations provide empirically derived target locations players adhere practice competition
paper analyzes present situation environmental problems china starting idea building green building using wireless sensor networks established building environment monitoring system based bim system monitor indoor air quality indoor temperature illumination time control temperature interior building set operating state air conditioning system analysis sunshine hours establish rational control strategy system control construction internal environment parameters meet standard green building establishment intelligent energy conservation harmonious living environment practice proved system used actual application bim monitoring platform building indoor environmental quality monitoring management verifies bim technology plays active effective role green building
adolescents high rates unintended pregnancy face unique reproductive health challenges providing confidential contraceptive services adolescents important reducing rate unintended pregnancy long acting contraception intrauterine device contraceptive implant recommended first line contraceptives adolescents highly effective side effects use barrier methods prevent sexually transmitted infections encouraged adolescents limited knowledge reproductive health contraceptive options sources information often unreliable access contraception available variety resources continue expand
examined ethnic discrimination targeting ethnic minority group members would affect majority group members attitudes multiculturalism towards ethnic minority groups context turkish kurdish interethnic conflict study demonstrated extent majorities turkish believed ethnic discrimination towards minorities kurdish turkish society associated positive outgroup attitudes support multiculturalism decreased levels perceived threat outgroup study showed turkish participants read bogus news reports prevalence ethnic discrimination towards kurdish positive towards ethnic group higher levels support multiculturalism culture maintenance intergroup contact compared participants neutral condition furthermore participants presented lower levels discrimination companies discriminatory kurdish positive towards kurdish people participants presented higher levels discrimination companies discriminatory kurdish regardless intensity discrimination information prevalence ethnic discrimination improved majority members attitudes towards ethnic minority groups practical theoretical implications studies discussed
economic relations modern enterprises important factor modern enterprise management manufacturing engineering mainly carried contract effectiveness contract foreign construction enterprises entering china market advantages powerful funds technology management china construction enterprises exert enormous pressure impact meanwhile construction enterprises order enter international market international competition without high level contract management reason china construction enterprises attention contract management improve awareness employees contract contract management business management allowed operate freely according law accelerate development construction enterprises china
full waveform inversion fwi aims recovering elastic parameters earth matching recordings ground motion direct solution wave equation modeling wave propagation realistic scenarios computationally intensive limits applicability fwi current hardware evolution brings increasing parallel computing power speed computations fwi however take advantage diversity parallel architectures presently available new programming approaches required work explore use opencl develop portable code take advantage many parallel processor architectures available present program called seiscl viscoelastic fwi time domain code computes forward adjoint wavefields using finite difference outputs gradient misfit function given adjoint state method demonstrate code portability different architectures performance seiscl tested three different devices intel cpus nvidia gpus intel xeon phi results show use gpus opencl speed computations nearly two orders magnitudes single threaded application cpu although opencl allows code portability show device specific optimization still required get best performance specific architecture using opencl conjunction mpi allows domain decomposition large models several devices located different nodes cluster large enough models speedup domain decomposition varies quasi linearly number devices finally investigate two different approaches compute gradient adjoint state method show significant advantages using opencl fwi
face face human interaction nonverbal communication plays fundamental role relevant aspect takes part social interactions represented mirroring person tends mimic non verbal behavior head body gestures vocal prosody etc counterpart paper introduce computer vision based system detect mirroring dyadic social interactions use wearable platform context mirroring inferred simultaneous head noddings displayed interlocutors approach consists following steps facial features extraction facial features stabilization head nodding recognition mirroring detection system achieves mirroring detection accuracy custom mirroring dataset elsevier rights reserved
aim water pollution unarguably one fundamental environmental issue global local level industrial wastewaters emerging challenging threat ecological balance aim present study investigate pollution load composite industrial effluents discharged state infrastructure industrial development corporation uttarakhand limited siidcul integrated industrial estate haridwar uttarakhand india reference ecological risks methodology due large outstretch industrial area industrial complex divided four clusters cluster cluster effluent samples collected drainage channels marked sampling sites industrial area standard methods apha followed analysis effluents samples results results revealed remarkably high pollution load industrial estate effluents discharged industrial units cluster slightly acidic parameters like tds bod cod heavy metals like exceeded permissible limits prescribed bureau indian standards bis thereby indicating considerably higher load pollutants load metals concentration effluents different clusters found following order higher content metals industrial wastewater may due discharge untreated effluents metal processing industries interpretation disposal effluents source severe ecological risks form contamination groundwater soil vegetation consumption crops vegetables irrigated effluents may serious threats human health thereby causing risk various ailments like encephalopathy cardiovascular kidney diseases muscular pain intestinal hemorrhage recommended pollution control regulatory authorities periodically monitor quality effluents ensure compliance prescribed standards
introduction street racing sport expansion used leisure sport competitive practice objective determine frequency sports injuries skin lesions athletes street racing material methods cross sectional study athletes street racing questionnaire clinical observation analysis test mann whitney chi square spearman correlation results predominance male athletes adults practitioners distance running training average minutes times week variable participation competitions main injuries reported knee pain ligament sprain muscle strain tendinitis pain hips back pain significant differences genders significant association miles covered training muscle damage men athletic footwear related presence ingrown nails nail loss women conclusion men showed higher frequency muscle injuries women skin nail disorders
aim investigate analgesic efficacy safety combined therapy using drotaverine ketorolac ketorolac treatment acute renal colic methods retrospective study consecutive cohort included emergency department patients diagnosis renal colic hospital june september pain intensity recorded using visual analog scale vas different time points treatment primary outcome defined decrease mean need rescue analgesics min occurrence adverse effects considered secondary outcomes results eligible patients patients analyzed study patients received ketorolac plus drotaverine patients received ketorolac significant differences two groups min min min min multivariable logistic regression min min univariable logistic regression moreover significant differences also found subgroup analysis patients mid proximal ureteric stones min multivariable logistic regression min univariable logistic regression pain relief min obtained patients receiving combined therapy patients receiving ketorolac rescue analgesics required six patients receiving combined therapy patients receiving ketorolac adverse events similar two groups combined group ketorolac group conclusion ketorolac combined drotaverine effective relief acute renal colic especially pain due mid proximal ureteric lithiasis decrease significantly renal colic patients renal distal ureteral stones hand combined therapy ketorolac drotaverine associated reduced use rescue analgesics
paper mainly discussed novel open experiment graduate course electronic information engineering course designed teach postgraduates design test simulate basic experiments related wireless communication systems microwave transmission systems using modern instruments computer aided design cad software one objectives course assist postgraduates understand theoretical concepts wireless systems parallel dsp embedded systems electromagnetic waves electromagnetic compatibility optical communication systems hands experiments make confident system design analysis course also aims increasing interest postgraduates engineering technology therefore laboratory experiments complementary materials discussed theoretical part course designed specifically incorporate use several common instruments students probably use extensively research fields complementing expanding upon materials covered six basic courses another merit laboratory based course meeting course requirements also helps students improve oral presentation report preparation abilities laboratory provided postgraduates past ten years opportunity acquire depth theoretical understanding hands experience rapidly growing discipline evaluation course indicates objectives achieved
multimodal actuator proposed fulfil different walking patterns power assisted knee exoskeleton actuator exoskeleton leg realize several modes operation including series elastic actuation stiff position control energy storage release energy amplification characteristics multimodal actuator series elastic mode analysed dynamics model established study series elasticity equivalent mass transmission influence power source electric motor results simulation experiment show series elasticity amplify actuator power output power output multi modal actuator greater equivalent mass transmission mechanism smaller research multimodal actuator energy amplification supplies important insights design artificial systems closely approximate performance biological systems
pervasive sensor driven systems nature open extensible terms input tasks required perform data streams coming sensors inherently noisy imprecise inaccurate differing sampling rates complex correlations characteristics pose significant challenge traditional approaches storing representing exchanging manipulating programming sensor data semantic web technologies provide uniform framework capturing properties offering powerful representation facilities reasoning techniques technologies rapidly gaining attention towards facing range issues data knowledge modelling querying reasoning service discovery privacy provenance article reviews application semantic web pervasive sensor driven systems focus information modelling reasoning along streaming data uncertainty handling strengths weaknesses current projected approaches analysed roadmap derived using semantic web platform open standard based pervasive adaptive sensor driven systems deployed elsevier rights reserved
background ankyrin gene ank produces ankyrin protein plays integral role regulating neuronal activity previous studies linked ank bipolar disorder schizophrenia recent mouse study suggests ank may regulate behavioral disinhibition stress reactivity led hypothesize ank might also associated stress related psychopathology posttraumatic stress disorder ptsd well disorders externalizing spectrum antisocial personality disorder substance related disorders etiologically linked impulsivity temperamental disinhibition methods examined possibility association ank snps ptsd externalizing defined factor score representing composite adult antisociality substance abuse cohort white non hispanic combat veterans intimate partners initially focused snp previously reported associated bipolar disorder schizophrenia ankyrin expression brain examined additional ank snps utilizing multiple testing correction results associated externalizing ptsd respectively analysis ank snps identified several strongly associated either trait significant association externalizing observed corrected significant association ptsd corrected found three snps complete linkage disequilibrium conclusions findings support role ank risk stress related externalizing disorders beyond previous associations bipolar disorder schizophrenia published elsevier ltd
ruxolitinib potent jak jak inhibitor demonstrated durable improvements splenomegaly symptoms overall survival controlled clinical trials patients myelofibrosis single arm study reported initiated collect safety efficacy data japanese patients myelofibrosis largest study ruxolitinib population primary objective assess safety secondary endpoints included changes spleen size patient reported outcomes primary analysis occurred patients completed weeks discontinued overall patients completed treatment discontinued due adverse events aes consistent previous studies common aes anemia thrombocytopenia furthermore levels select immunologic biomarkers remained stable deaths occurred week evaluable patients experienced reductions baseline palpable spleen length reductions spleen volume additionally ruxolitinib led clinically significant improvements symptoms quality life overall findings study indicate ruxolitinib safe effective japanese patients myelofibrosis benefits extending patients intermediate risk myelofibrosis low platelet counts
measuring impact image based web technologies educational communication part larger theses aimed determine overall impact image based web technologies visual communication particular chapter try monitor impact technologies social progress visual communication academic education two societies romania usa end chose two renowned polytechnic universities countries representative engineering robotics computer programming exposed areas progress society massachusetts institute technology mit politehnica university timisoara upt case study report presence university romania web platforms university presence platforms determining degree impact technologies visual communication education
context researchers identified high exposure game conditions low back dysfunction poor endurance core musculature strong predictors occurrence sprains strains among collegiate football players objective refine previously developed injury prediction model analysis consecutive seasons data design cohort study setting national collegiate athletic association division football championship subdivision football program patients participants consecutive years team members age years height mass presented mandatory physical examination day initiation preseason practice sessions main outcome measure associations preseason measurements subsequent occurrence core lower extremity sprain strain established player seasons data used receiver operating characteristic analysis identify optimal cut points dichotomous categorizations cases high risk low risk logistic regression cox regression analyses used identify multivariable injury prediction model optimal discriminatory power results exceptionally good discrimination injured uninjured cases found factor prediction model included equal greater game starter oswestry disability index score equal greater poor wall sit hold performance existence least risk factors demonstrated sensitivity specificity odds ratio confidence interval hazard ratio confidence interval conclusions high exposure game conditions dominant injury risk factor collegiate football players surprisingly mild degree low back dysfunction poor core muscle endurance appeared important modifiable risk factors identified addressed participation
application fuzzy rule interpolation fri escalating making intelligent systems viable many areas however requirements systems may change time supporting static rule base may able provide accurate interpolation results long run dynamic fuzzy rule interpolation fri one potential solutions problem developed last years fulfil requirements dynamic pertinent rule bases intelligent systems nevertheless applications proposed fri approach need investigation one potential application network security one biggest concerns organisation irrespective size nature business intrusion detection systems idss considered one popular effective security tools generating alerts systems network administrators inform possible existing threats standard ids may effective even unsuitable organisational individual requirements paper presents application fri building effective ids implementation popular open source ids snort used resultant intelligent ids named fri snort experimental analysis shows integration fri ids snort provides additional level intelligence predict level sensitivity possible threats also provides dynamic rule base promoting new rules based current network traffic conditions helps snort reduce false positives false negatives
first time systematic synthesis method cross coupled dispersive delay structures ddss controlled magnitude analog signal processing applications proposed method transfer function synthesized using polynomial expansion approach allows separately control magnitude group delay response dds synthesized transfer function also features reduced order namely half compared previously reported synthesis techniques linear phase filters constructed transfer function transferred coupling matrices implemented arbitrary cross coupled resonator technologies several design examples provided different prescribed group delay responses experimental waveguide prototype demonstrated agreement measured prescribed responses illustrates proposed synthesis method
study investigated recovery process grafted cultured epithelium generated skin elasticity skin surface microarchitecture subjects patients whose burn scars excised depth exposing fat layer subsequently received cultured epithelial autografts total samples obtained grafted sites samples within weeks stage samples weeks within months stage samples months within months stage samples beyond months stage transplantation samples evaluated taking replicas skin surface histological changes fibrillin elastin expression patterns classified using grading scale grade skin surface texture significantly higher stage marginally significantly higher stage compared stage grade fibrillin marginally significantly higher stage significantly higher stage compared stage grade elastin marginally significantly higher stage compared stage results showed important patients skin care avoid external forces least months transplantation
paper fractional order controller designs integer first order plus time delay systems investigated based bode ideal transfer function reference model new structure fractional order controller proposed internal model control principle used design controllers effectiveness controllers demonstrated simulations efficiency validated experimentation heat flow platform
reliable synchronous machine modeling key accurate power system planning operation post event analysis especially emerging smart grids literature various models synchronous machine different number parameters used little attention paid significance parameter originally nonlinear model paper first shrinkage term selection method extended identification nonlinear systems extended method applied synchronous machine identification problem order determine parameters substantial impacts machine response model parameters partitioned well ill conditioned sets shown ill conditioned parameters set typical values allow significant improvements identifiability speed convergence estimated parameters without loosing capability characterize system result parameter estimation done reduced order optimization problem leads reliable estimation lower variances faster convergence especially line measurements performance effectiveness proposed nonlinear term selection method demonstrated using numerical simulations compared results two existing approaches elsevier ltd rights reserved
paper present analysis low complexity signal processing algorithms capable identifying special noises sounds forest machinery used forestry logging objective find methods able detect internal combustion engines rural environment also easy implement low power devices wsns wireless sensor networks context review different methods detecting illegal logging emphasis autocorrelation tespar audio techniques processing extracted audio features solved limited memory processor resources typical low cost sensors modes representation noise models also considered different archetypes implementations proposed methods tested simulations sensor nodes equipped omnidirectional microphone low power microcontroller results show high recognition rate achieved using time domain algorithms highly energy efficient inexpensive architectures
clostridium difficile causes nosocomial antibiotic associated diarrhoea pseudomembranous colitis major virulence factors toxin toxin tcdb inactivate gtpases monoglucosylation leading cytopathic cytoskeleton alteration cell rounding cytotoxic effects cell cycle arrest apoptosis difficile toxins breaching intestinal epithelial barrier act underlying cells enterocytes colonocytes enteric neurons described vitro vivo data available enteric glial cell egc susceptibility egcs crucial regulating enteric nervous system gut homeostasis immune inflammatory responses digestive extradigestive diseases therefore evaluated effects difficile tcdb egcs rat transformed egcs treated tcdb several parameters analysed tcdb induces following egcs early cell rounding rac glucosylation early cell cycle arrest cyclin cdc complex inactivation caused upregulation downregulation cyclin cdc phosphorylated thr tyr apoptosis caspase dependent mitochondria independent pathway importantly stimulation egcs tnf alpha plus ifn gamma concomitantly tcdb treatment strongly increased tcdb induced apoptosis furthermore egcs survived cytotoxic effect tcdb recover completely showed persistent rac glucosylation cell cycle arrest low apoptosis also increased production glial cell derived neurotrophic factor suggesting self rescuing mechanisms conclusion high susceptibility egcs tcdb vitro increased sensitivity inflammatory cytokines related apoptosis persistence altered functions surviving cells suggest important vivo role egcs pathogenesis difficile infection
low testosterone level associated increased risks cardiovascular diseases obese insulin resistant condition could impair cardiac function incidence obesity increased aging men condition testosterone deprivation could aggravate cardiac dysfunction obese insulin resistant subjects however mechanism underlying adverse effect unclear study investigated effects obesity metabolic parameters heart rate variability hrv left ventricular function cardiac mitochondrial function testosterone deprived rats orchiectomized sham operated male wistar rats per group randomly divided groups given either normal diet energy fat high fat diet hfd energy fat weeks metabolic parameters hrv function cardiac mitochondrial function determined weeks starting feeding program found insulin resistance observed weeks consumption hfd sham hfs orchiectomized hfo rats neither sham nds group orchiectomized ndo rats developed insulin resistance development depressed hrv contractile dysfunction increased cardiac mitochondrial reactive oxygen species production observed earlier orchiectomized ndo hfo rats week whereas hfs rats exhibited impairments later week findings suggest testosterone deprivation accelerates impairment cardiac autonomic regulation function via increased oxidative stress impaired cardiac mitochondrial function obese orchiectomized male rats
optimal productivity highest sustainable productivity level achievable good management typical working conditions accordingly optimal productivity provides foundation determining absolute efficiency construction operations accurate estimate optimal productivity enables comparison actual versus optimal rather actual versus historical productivity research contributes current body knowledge introducing two prong strategy estimating optimal productivity labor intensive construction operations applying strategy pilot study replacement electrical lighting fixtures first prong top approach estimates upper limit optimal productivity introducing system inefficiencies productivity frontier productivity achieved perfect conditions study uses qualitative factor model identify upper limit second prong bottom approach estimates lower limit optimal productivity taking away operational inefficiencies actual productivity productivity recorded field discrete event simulation model provides lower limit value average upper lower limits yields best estimate optimal productivity paper reviews relevant literature presents details top bottom approaches analyzes data pilot project evaluates feasibility two prong strategy finally provides novel framework project managers want accurately estimate optimal productivity labor intensive construction operations american society civil engineers
propose new class profiler distributed heterogeneous systems systems task may wait result another task either locally remotely wait dependencies invisible instruction profilers propose host based precise method recover recursively wait causes across machines using blocking fundamental mechanism detect changes control flow relies solely operating system events namely scheduling interrupts network events therefore capable observing kernel threads interactions achieves user space runtime independence given task algorithm computes active path trace presented interactive viewer inspection validated new method workloads representing major architecture operating conditions found distributed programs used method analyze execution behavior five different distributed systems found worst case tracing overhead distributed application percent typical average overhead percent analysis implementation linear runtime according trace size
paper two day workshop model predictive controllers mpc developed practiced goal introduce concept mpc easy motivating fashion end second day students familiar basics mpc also capable indipendently program tune observe performance mpc various applications course mainly designed students basic control engineering background elementary matlab simulink experience ifac international federation automatic control hosting elsevier ltd rights reserved
background study explored association single nucleotide polymorphisms snps gene well disease susceptibility severity knee osteoarthritis koa chinese han population method peripheral venous blood collected koa patients koa group healthy people control group december november patients koa group classified mild moderate severe groups according disease severity polymerase chain reaction restriction fragment length polymorphism pcr rflp used test genotypes subjects binary logistic regression analyses performed analyze risk factors koa results koa group significantly different control group living environment compared control group genotype allele may associate low incidence koa increased susceptibility koa genotype allele distribution significantly different among mild moderate severe groups genotype genotype severe group genotypes two snps according binary logistic regression analysis genotype could alleviate disease severity koa genotype increase severity koa living environment important external factor affects koa severity conclusions data provide evidences gene may associated disease susceptibility severity koa
background purpose atherogenic changes lipids occur among women around time natural menopause within year final menstrual period fmp investigated whether lipid changes around fmp related carotid intima media thickness interadventitial diameter plaque postmenopausal women methods total natural postmenopausal women history heart attack stroke underwent carotid ultrasound scans follow year study women health across nation estimates annual change lipids segmented year fmp year fmp year fmp multivariate analyses adjusted sociodemographic characteristics time fmp scan baseline body mass index systolic blood pressure use medications hypertension diabetes mellitus scan results smaller increases high density lipoprotein cholesterol apolipoprotein within year fmp related greater interadventitial diameter beta beta respectively greater increases low density lipoprotein cholesterol within year fmp related greater likelihood plaque scores odds ratio confidence interval magnitude associations reduced remained significant adjustment premenopausal lipid levels difference probability elevated plaque scores highest lowest low density lipoprotein cholesterol change tertiles conclusions changes lipids women approach fmp provide useful clinical information understanding postmenopausal carotid indices
present study aim providing evidences validity initiation processes impairment autism spectrum disorder asd applied different verbal fluency tasks designed decrease enhance limitation group high functioning individuals asd group typically developed individuals matched age education tested three verbal fluency tasks task replicated previous findings initiation impairment tasks simple manipulations observed differences groups respectively eliminated enhanced provided evidence impairments initiation response remarkably show circumvent
river pollution one challenging environmental issues effect river pollution levels biofilm communities well studied spatial temporal distribution characteristics environmental parameters biofilm communities investigated qinhuai river basin nanjing china water samples grouped three clusters reflecting varying pollution levels relatively slight pollution moderated pollution high pollution hierarchical cluster analysis different clusters biofilm communities mainly differed proportion actinobacteria firmicutes proteobacteria dominant classes proteobacteria alpha beta gammaproteobacteria seemed show upward trend followed small fluctuation abundance escalation water pollution level results redundancy analysis demonstrated temperature total nitrogen total phosphorus ratios concentrations ammonia nitrogen mainly responsible variation bacterial community structure occurrences alpha beta gammaproteobacteria closely associated higher temperature higher concentrations lower ratio study may provide theoretical basis water pollution control ecological restoration urban rivers different pollution levels
people agenesis corpus callosum agcc normal general intelligence deficits complex cognitive processing well social cognition uncertain extent impoverished processing emotions may contribute social processing deficiencies used mayer salovey caruso emotional intelligence test clarify nature emotional intelligence adults agcc hypothesized persons agcc exhibited greater disparities norms tests involving socially complex aspects emotions agcc group differ norms experiential subscale significantly norms strategic subscale findings suggest corpus callosum essential experiencing thinking basic emotions normal way necessary complex processes involving emotions context social interactions
much known young children helping behavior little known underlying motivations emotions involved studies found year old children showed positive emotions similar magnitude measured changes postural elevation using depth sensor imaging technology achieved goal helped another person achieve goal conversely children posture decreased elevation actions result positive outcome results suggest young children working helping others similarly rewarding
one class classification belongs one novel promising topics contemporary machine learning recent years ensemble approaches gained significant attention due increasing robustness unknown outliers reducing complexity learning process previous works proposed highly efficient one class classifier ensemble based input data clustering training weighted one class classifiers clustered subsets however main drawback approach lied difficult time consuming selection number competence areas indirectly affects number members ensemble paper investigate ten different methodologies automatic determination optimal number competence areas proposed ensemble roots model selection clustering also effectively applied classification task order select useful technique investigate performance number one class multi class problems numerous experimental results backed statistical testing allows propose efficient fully automatic method tuning one class clustering based ensembles
background utilities disability weights dws metrics used calculating quality adjusted life years disability adjusted life years dalys respectively utilities obtained multi attribute instruments euroqol dimensions questionnaire salomon proposed set dws health states respectively objective study develop approach mapping utilities existing gbd gbd dws allowing predict new gbd dws based utilities methods conducted two pilot studies including respectively four twenty seven health states selected dws gbd study first study participant evaluated four health conditions using standard written questionnaire second study participant evaluated four health conditions randomly selected among twenty seven health states using previously developed web based questionnaire responses translated utilities using model developed cleemput loess regression allowed map utilities logit transformed dws results overall respondents completed first second survey respectively first study monotonic relationship derived utilities predicted gbd dws observed second study important differences ranking health states based utilities versus gbd dws participants current study attributed relatively higher severity level musculoskeletal disorders amputation legs relatively lower severity level non functional disorders headache migraine compared participants gbd studies conclusion study suggests possibility translate utility derived scores also highlights important caveats observed satisfactory result methodology utilities derived population public health students written questionnaire small number health states presence study leader however results unsatisfactory utilities derived sample general population using web based questionnaire recommend repeat study larger diverse sample obtain representative distribution educational level age
discuss long time dynamical behavior non autonomous suspension bridge type equation nonlinearity translation compact time dependent external forces satisfy condition instead translation compact applying new results energy estimate technique existence uniform attractors obtained result improves extends known results
viirs dnb sensor launched offers remote sensing community improved capabilities monitoring quantifying nighttime brightness far studies temporal changes nighttime lights focused examining inter annual trends sudden changes light emission related demographic economic reasons recently released two year set monthly cloud free viirs dnb composites used explicitly examine seasonal changes nighttime lights correspondence seasonality land cover northern central america found monthly changes nighttime brightness positively correlated monthly changes snow cover albedo negatively correlated monthly changes ndvi correlations strongest urban areas northeast usa high correlation coefficient values obtained seasonality nighttime brightness thus important factor consider quantifying trends light emission annual time series studies examining adverse consequences artificial lights human health environment elsevier inc rights reserved
paper describes environment assess auditory emotional recognition based mobile application primary aim work provide valuable instrument used research clinical settings responding strong need validated measures emotional processing especially portugal secondary aim acquire study participants interaction behavior technological device touch patterns touch intensity search relationship medical conditions cognitive impairments auditory emotional recognition capacities socio demographic indicators establish basis prediction aspects function individual interaction technological devices potentially providing new diagnostic tools
paper addresses child abuse social services protection builds upon study verdicts concerning care young persons act cypa aim explore extent characterised violence children subjected central finding applications cypa one year concerning children years concerned children reported subjected violence violence cases described severe systematically exerted many years intimidating tactics power control girls boys question care violence girls also greater extent reported subjected sexual abuse coercive control sexuality relation standards regarding honour virginity international perspective findings said confirm need analyse factors gender power control research interventions concerns children abused parents swedish context findings said suggest cypa crucial intervention protect children violence
paper addresses fundamental search problem searcher subject time energy constraints tries find mobile target target motion modeled random walk discrete set points line segment time step target chooses one adjacent nodes random moves study two detection models crossing model searcher detects target node takes edge time crossing model detection happens target lands node time crossing model move stay actions may different costs present optimal search strategy energy time constraints crossing model formulate problem designing optimal strategy partially observable markov decision process pomdp solve using methods reduce state space representation belief pomdp solution reveals structural properties optimal solution use structure design efficient strategy analytically study performance finally present preliminary experimental results demonstrate applicability model tracking system used finding radio tagged invasive fish
aimcryoglobulinaemic glomerulonephritis related hepatitis virus hbv infection rarely reported aim study investigate clinical features renal biopsy findings patients hbv associated cryoglobulinaemia methodstwelve patients hbv associated cryoglobulinaemia identified study demographic clinical pathological characteristics treatment follow data analyzed resultsrenal involvement characterized nephrotic range proteinuria microscopic haematuria patients impaired renal function nine patients purpuric rash main extrarenal manifestation type cryoglobulinaemia presented three patients type iii nine patients hypocomplementaemia positive rheumatoid factors present patients membranoproliferative glomerulonephritis mpgn observed kidney specimens seven patients also evidence prominent cryoglobulins thrombi renal biopsy three patients hbv antigen deposits renal tissues antiviral steroids immunosuppressive agents used patients follow two patients died four reaching end stage renal disease three patients complete remission three patients renal function improved therapy conclusionsnephrotic syndrome haematuria renal insufficiency main clinical manifestation cryoglobulinaemic glomerulonephritis main renal lesion patients hbv associated cryoglobulinaemia half patients poor outcome even antiviral immunosuppressive therapy results study indicate cryoglobulins detected hepatitis virus associated nephropathy endemic area
background numerous surgical options exist treat chondral lesions knee including microfracture mfx osteochondral autograft transplantation oat first generation autologous chondrocyte implantation aci next generation aci aci purpose compare cost effectiveness mfx oat aci secondary purpose study compare functional outcomes mfx oat aci aci study design systematic review level evidence methods two independent reviewers conducted online literature search databases level studies using lysholm international knee documentation committee ikdc knee injury osteoarthritis outcome score koos hospital special surgery hss knee score weighted mean difference pre postoperative functional outcome score calculated treatment mean per patient costs associated mfx oat aci determined recent publication based review national private insurance database cost procedure divided weighted mean difference functional outcome score give cost per point change outcome score results total studies level level met inclusion criteria functional outcome analysis including knees mfx oat aci aci mean follow significantly different groups mfx months oat months aci months aci months mean increase functional outcome score mfx oat aci aci change functional outcome score significantly greater aci compared treatments cost per point change functional outcome score mfx oat aci conclusion mfx oat aci aci effective surgical procedures treatment cartilage defects knee treatments led increase functional outcome scores postoperatively short term follow aci statistically greater improvement functional outcome scores compared procedures mfx found cost effective treatment option aci least cost effective
control harmful algae coves bays larger water bodies could accomplished hydraulic flushing algae free water suggestion examined mathematical model harmful algal population parameterized represent toxic haptophyte prymnesium parvum limiting nutrient small cove hydraulic storage zone longitudinal advection dispersion coupled larger lake ongoing transient blooms serve source algal population population transported upstream dispersion flushed downstream advection morphometry hydraulics represent lake texas blooms parvum problematic dispersion hydraulic storage low moderate available pumping technology predicted capable suppressing algal population within variable portion cove steady state transient conditions suppression occurs temperature dependent algal growth low temperatures high enough support rapid growth flow augmentation carries risk stimulating bloom hydraulic conditions model presented complements similar models without population sources contributes theoretical understanding population persistence reservoirs flowing water habitats elsevier rights reserved
work numerically studies transient behaviour particulate flows cylindrical conical spouted bed terms comparative analysis different models predictions two approaches used laminar flow model turbulent flow model reference case consider experimental studies profiles vertical particle velocities void fraction spout fountain full column spout bed measured work used euler euler unsteady multiphase model syamlal brien gidaspow wen drag models available commercial cfd software fluent analysis results obtained use laminar turbulent flow models revealed almost identical solid gas phase velocities phase fractions within spouted bed region found turbulence plays significant role gas phase spouted bed influence solid phase comparing simulation results form time averaged vertical velocity solid phase experimental data showed acceptable agreement spout good agreement fountain region numerical simulations syamlal brien drag model gave better agreement experimental data results obtained using gidaspow wen drag models analyze transient behaviour spouted bed use volume averaged particle velocity gas phase velocity analysis time histories showed start time developed unsteady regime reached additionally studied numerically influence different discretization schemes convective terms final results found use order upwind scheme gives steady state solution models laminar turbulent finally investigated influence restitution coefficient transient characteristics cylindrical conical spouted bed decrease value restitution coefficient leads increase period oscillations volume averaged velocities gas solid phases
nanoindentation measurements along atomic force microscopy ray diffraction residual stress analyses basis raman measurements performed characterize stress tailored thin films grown using reactive magnetron sputtering intrinsic stress gradient caused growing plane grain size along film thickness minimized increasing concentration gas mixture growth process increase concentration degrade device relevant material properties crystallographic orientation surface morphology piezoelectric response indentation modulus due comparable crystallographic film properties investigated samples concluded mainly crystallites contribute mechanical film properties indentation modulus hardness film stress grain boundaries minor influence therefore tailoring stress gradient films device performance fabrication yield design flexibility electro acoustic devices greatly improved elsevier rights reserved
aspirin hypersensitivity associated chronic rhinosinusitis without nasal polyposis asthma resistant conventional therapy defines aspirin exacerbated respiratory disease aerd describe case year old female patient adverse reaction aspirin chronic rhinosinusitis severe asthma also experienced chronic idiopathic urticaria worsened non steroidal anti inflammatory drug administration aerd diagnosed based clinical history symptoms given poor responsiveness standard therapy respiratory cutaneous symptoms omalizumab administered weeks control respiratory symptoms short term improvement cutaneous symptoms wiley periodicals inc
water permeability woven geotextile usually measured uncompressed state compressive stresses varies significantly tensile loads study permeability behaviours woven geotextile tensioned state series laboratory experiments carried one type woven polypropylene geotextile tensile strength experimental results show permittivity geotextile tension load warp direction first decreases rapidly approaches value one absence load contrary permittivity increases increase tension force weft direction steady value observed since tension load warp direction obviously influence water permeability geotextile tensile strain recommended applied warp fibres initially determining reasonable permittivity laboratory test elsevier ltd rights reserved
one challenging issues high resolution remote sensing images classifying land use scenes high quality accuracy effective feature extractor classifier boost classification accuracy scene classification letter proposes deep learning based classification method combines convolutional neural networks cnns extreme learning machine elm improve classification performance pretrained cnn initially used learn deep robust features however generalization ability finite suboptimal traditional cnn adopts fully connected layers classifier use elm classifier cnn learned features instead fully connected layers cnn obtain excellent results effectiveness proposed method tested merced data set remotely sensed land use scene images categories experimental results show proposed cnn elm classification method achieves satisfactory results
among different processes producing biodiesel fuel use methanol conditions near critical point promissory alternative reactive distillation proposed reduce energy requirements esterification step process reductions accompanied reductions total annual costs environmental impact however due conditions column operated special care must taken design trays hydraulic performance proper design trays prevent operational problems work strategy mechanical design sieve trays homogeneous reactive distillation column presented column oleic acid esterified methanol pressure mpa designs obtained tested terms hydraulics cfd simulations cfd analysis carried using ansys fluent software elsevier rights reserved
ankylosing spondylitis chronic systemic inflammatory disease via autoimmune mediators damage auditory system similar systems otoacoustic emission studies patients showed damage causes hearing loss outer hair cells medial olivocochlear moc reflex used evaluate moc efferent system moes includes outer hair cells aim study evaluate presence subclinical damage inner ear aid moc reflex test patients hearing complaints thirty four patients control group healthy volunteers similar demographic characteristics evaluated study otoacoustic emission responses moc reflex results frequency specific total suppression findings compared groups relationship clinical laboratory findings patients moc reflex data also investigated reduced moc reflex response suppression detected patients clinical laboratory findings patients moc reflex test results compared significant correlation found moc reflex erythrocyte sedimentation rate results showed damage inner ear especially moes reduce moc reflex response without clinical hearing loss
presence describes feeling reality immersion users virtual internet environments importantly suggested individual contextual differences regarding susceptibility presence aspects presence linked beneficial disadvantageous uses internet online therapeutic applications addictive internet behaviours present study presence studied relation individual anxiety symptoms classroom level openness experience ote using normative sample adolescents aged years presence assessed presence questionnaire anxiety symptoms relevant subscales scl ote five factor questionnaire three level hierarchical linear model calculated results showed experiencing presence virtual environments dropped ages years additionally although anxiety symptoms associated higher presence years association decreased age results also demonstrated adolescents classrooms higher ote reported reduced level experiencing presence practical theoretical implications findings discussed
design multi dimensional control system three dimensional warehouse including warehouse temperature umidity monitoring system design anti theft system design control design warehouse optimize goods storage environment improve safety performance traditional control system design using epga cpld control scheme real time stability good question warehouse technology devicenet field bus control system design proposed give full play performance superiority design extended flash chip design temperature humidity control module information collection module constructs overall model multi dimensional three dimensional warehouse control system automatic fire alarm module temperature humidity automatic early warning module adaptive fuzzy control strategy algorithm design control system simulation results show algorithm effectively realize comprehensive multi dimensional three dimensional warehouse control monitoring temperature control precision degree relative humidity control accuracy effectively ensure safety performance warehouse storage
work introduces framework study network formed autonomic component heart rate variability cardiac process eta amplitude different electroencephalographic waves brain processes delta theta alpha sigma beta sleep framework exploits multivariate linear models decompose predictability given target process measures self causal interaction predictability reflecting respectively information retained process related physiological complexity information transferred source processes information modified transfer according redundant synergistic interaction sources framework applied eta delta theta alpha sigma beta time series measured sleep recordings eight severe sleep apnoea hypopnoea syndrome sahs patients studied long term treatment continuous positive airway pressure cpap therapy healthy controls results show full self predictability eta delta theta decreased significantly sahs compared controls restored cpap delta theta eta causal predictability eta delta occurred significantly redundant source interaction healthy sleep lost sahs recovered cpap results indicate predictability analysis viable tool assess modifications complexity causality cerebral cardiac processes induced sleep disorders monitor restoration neuroautonomic control processes long term treatment
objective aimed find prognostic factors detect patients fail treatment epilepsy early stages disease materials methods study done epileptic patients attending neurology clinic mofid children hospital tehran iran september october defining criteria exclusion inclusion patients divided two groups based responding medical treatment epilepsy indices recorded patients used statistical analyses results patients age ranged patients refractory seizure group experimental group patient well controlled seizure group control group significant different serum drug level groups patients refractory seizure group lower serum drug level control group groups tonic clonic common type seizure also prevalence brain imaging abnormalityand neurologic disorders significantly higher patients refractory seizure compare control group conclusion children seizure suffer refractory epilepsy need attention exact observation medical staff
sheep offers unique mammalian model study paradoxical sex sexual partner preferences variations sexual partner preferences occur spontaneously many rams population exhibiting sexual preference rams male oriented current review presents overview update male oriented ram model discusses several theories invoked explain sex preferences species although understanding biological determinants underlying neural substrates sexual attraction mate selection far complete compelling evidence discussed supports idea neural substrates regulating sexual partner preferences organized prenatal development challenge future research construct integrated picture hormones genes experience shape sexual partner preference elsevier inc rights reserved
efficient processing aggregated range queries two dimensional grids common requirement information retrieval data mining systems example geographic information systems olap cubes introduce technique represent grids supporting aggregated range queries requires little space data points grid clustered common practice show general technique used support two important types aggregated queries ranked range queries counting range queries experimental evaluation shows technique speed aggregated queries order magnitude small space overhead elsevier ltd rights reserved
rationale graphic health warnings ghws cigarette packages present important tobacco control opportunity particularly vulnerable populations suffering disproportionate tobacco burden one mechanism ghws may influence smoking outcomes prompting interpersonal discussions within health discussion networks set personal contacts individual discusses health issues objective study examined association ghw prompted conversations within health discussion networks key tobacco related outcomes attention valence content discussions method august april recruited individuals three communities massachusetts emphasizing recruitment individuals low socioeconomic position sep members selected vulnerable groups respondents exposed nine ghws proposed fda asked series questions assessed follow weeks later results total individuals included analysis respondents reported health discussion network significantly lower reports among african americans hispanics compared whites around respondents smokers nonsmokers health discussion networks reported one conversations ghws network members bulk negative focused warning others smoking smokers found small positive association percentage network conversations negative reports quit attempts conclusion results point potential mechanism ghws may impact tobacco related outcomes prompting inquiry role health discussion networks discussion networks broadly tobacco control among low sep individuals elsevier ltd rights reserved
formation coherent unified self concept represents key developmental stage adolescence imaging studies self referential processing adolescents rare clear whether neural structures involved self reflection also involved reflections familiar others current study adolescents asked make judgments trait adjectives functional magnetic resonance imaging fmri indicate whether word describes friends teachers politicians findings indicate greater overlap neural networks responses self friend related judgments compared teachers politicians particular classic self reference structures ventromedial prefrontal cortex medial posterior parietal cortex also exhibited higher activation judgments friends contrast brain responses towards judgments teachers familiar others compared politicians unfamiliar others significantly differ results support behavioral findings greater relevance friends development self concept adolescence indicate underlying functional brain processes hum brain mapp wiley periodicals inc
purpose aimed identify topics research neglected undervalued overseen past decades placebo nocebo research methods highly specialized literature database containing articles placebo nocebo effects response screened articles covering placebo effects nutrition sports medicine physical therapy psychotherapy article covering gender age culture influencing factors articles dealing long term outcome multimodality articles related technical ehealth mhealth aspects placebo effects findings although placebo research gained substantial progress past decades resolved puzzles ignored obvious less obvious facets placebo topic overlooked years medicine developed progressed doctor patient relationship social environment communication happens implications biggest threat placebo research may outdate declaring everything placebo effect even may better terms concepts patient expectations doctor patient communication empathy ignoring medicine continuously changes face patients well clinical researchers biggest opportunity fact topic medicine requires medical psychological experts exploration stay updated elsevier journals inc rights reserved
background concepts successful aging usual aging mild cognitive impairment mci developed identify older adults high risk alzheimer diseases however predictors rarely investigated single study thus study aims explore risk factors mci compared among older adults large community based cohort study malaysia method subjects four states malaysia recruited comprehensive interview based questionnaire administered determine socio demographic information followed assessments evaluate cognitive function functional status dietary intake lifestyle psychosocial status risk factors cognitive impairment assessed using ordinal logistic regression olr result prevalence mci study respectively olr indicated higher fasting blood sugar hyperlipidemia disability lower education level regularly involved technical based activities limited use modern technologies lower intake fruits fresh fruit juices practicing calorie restriction among risk factors poor cognitive performance study conclusion study stepping stone future researchers develop intervention strategies prevent cognitive decline
aim assess usefulness spectral data detect structural physiological changes citrus crops tinder water saline stress multispectral images acquired fixed wing unmanned aerial vehicle uav concomitant measurements gas exchange plant water status leaf structural traits chlorophyll taken commercial farm located southeast spain two citrus species grapefruit mandarin irrigated eight years saline reclaimed water combined regulated deficit irrigation rdi measurements leaf scale airborne flights carried twice day gmt irrigation decreased gas exchange leaf dry mass per unit area lma grapefruit however salinity resulted increase pressure potential gyp mandarin allowed maintaining net photosynthesis stomatal conductance vapour pressure deficit increased crops leaf total chlorophyll chlt concentrations significantly reduced moreover rdi decreased stem water potential psi grapefruit independently water quality regarding spectral data red wavelength significantly correlated chl except mandarin subjected stressful climatic conditions gmt since influenced addition chl plant water gas exchange status near infrared nir useful indicator psi crops normalized difference vegetation index ndvi clearly related gas exchange species psi mandarin finally combined data citrus species best indicators nir novelty study show diurnal changes physiological structural traits citrus irrigated combined rdi determined multispectral images uavs elsevier rights reserved
injuries hand wrist common sports injuries diagnosis therapy wrist injuries becoming important especially increasingly popular ball hitting sports golf tennis baseball ulnar sided wrist pain initially often misdiagnosed treated tenosynovitis tendinitis tears triangular fibrocartilage complex tfcc fractures hook hamate bone also occur sports seldomly diagnosed aim study conduct systematic review literature focussing tfcc lesions fractures hook hamate bone racquet sports baseball golf systematic review literature performed pubmed occurrence tfcc lesions fractures hook hamate bone studies case reports included rarity injuries exclusion criteria concerning number cases injuries associated ball hitting sports tfcc lesions fractures hook hamate bone still underrepresented current literature sports injuries diagnosis treatment injuries often delayed severely handicap performance career affected professional well amateur athletes
objective review cell specific amounts intracellular androgens made women circulating dehydroepiandrosterone dhea peripheral tissue independently rest body following million years evolution approximately three dozen cell specific intracrine enzymes engineered human peripheral tissues whereby inactive sex steroid precursor dhea mainly adrenal origin transformed appropriate minute intracellular amounts androgens intracellular androgens inactivated cells biologically significant release active androgens circulation best estimate approximately much androgens synthesized women compared men age problem dhea however exclusive source androgens women ages dhea secretion already decreased average time menopause continues decrease thereafter human specific highly sophisticated mechanisms intracrinology permit cell control androgen availability according needs independently remaining body mechanism completely different classical endocrinology well understood men testosterone testicular origin transported blood indiscriminate access androgen receptor containing cells body men endocrine intracrine mechanisms operation women intracrine mechanisms responsible intracellular formation dhea provide androgens elsevier ltd rights reserved
oxidative stress thought involved development parkinson disease previously reported bibenzyl compound isolated gastrodia elata possesses antioxidative properties depth molecular mechanisms rotenone induced neurotoxicity remains unknown recent studies indicate without intact nuclear factor erythroid related factor nrf protein becomes unstable activity nrf mediated downstream antioxidant enzymes thereby suppressed study showed clearly protected syy cells rotenone induced oxidative injury furthermore markedly regulated levels turn activated phosphoinositide kinase pik akt signaling inhibited glycogen synthase kinase beta gsk beta activation eventually promoted nuclear translocation nrf induced expression hemeoxygenase antioxidant effects could partially blocked shrna mediated knockdown inhibition pik akt pathways akt kinase inhibitor respectively conclusively findings confirm necessary mediated protection rotenone induced oxidative damage least part activating pik akt signaling subsequently enhancing nuclear accumulation nrf findings investigation suggest developed novel candidate alleviating consequences future elsevier rights reserved
background depression pregnancy common high impact disease generally pregnant women suffer depression children exposed maternal depression pregnancy higher risk adverse birth outcomes often show cognitive emotional behavioural problems therefore early detection treatment antepartum depression necessary psychotherapy antidepressant medication first choice treatments non pregnant population limitations treating depression pregnancy therefore urgent relevant investigate alternative treatments antepartum depression bright light therapy blt promising treatment pregnant women depressive disorder combines direct availability sufficient efficacy low costs high safety taking safety unborn child account well methods study pregnant women weeks pregnant dsm diagnosis depressive disorder randomly allocated ratio one two treatment arms treatment blt lux treatment dim red light therapy lux groups treated weeks home daily basis min within min habitual wake time follow take place weeks therapy weeks end therapy birth months postpartum primary outcome average change depressive symptoms two groups measured structured interview guide hamilton depression scale seasonal affective disorder version edinburg postnatal depression scale changes rating scale scores questionnaires time analysed using generalized linear mixed models secondary outcomes changes maternal cortisol melatonin levels maternal sleep quality gestational age birth weight infant behaviour infant cortisol exposure infant cortisol stress response discussion blt reduces depressive symptoms pregnant women provide safe cheap non pharmacological efficacious alternative treatment psychotherapy antidepressant medication treating antepartum depression without expected adverse reactions unborn child
study seeks determine main events occur development ciliary body week development develops distal portion optic cup neighboring mesenchyme week development zones observed distal portion zone epithelia outer inner layers came contact contact coincided appearance mainly apical granule pigments zone corresponded anlage epithelial layers zone cells surrounded marginal sinus contained scarce pigment granules nuclei basal position zone corresponded anlage iris zone triangular shape vertex ran towards marginal sinus corresponded common cell progenitors zone corresponded retinal pigment epithelium anlage neural retina anlage determined onset stroma ciliary muscle anlage end week week observed anlage orbicularis ciliaris pars plana corona ciliaris pars plicata addition anlage ciliary muscle study therefore establishes precise timetable development karger basel
objective roles hippocampal ampars investigated irritable bowel syndrome ibs like rats clarify central sensitization mechanisms methods ibs model induced neonatal maternal separation effects ampars visceral hypersensitivity examined responses abdominal muscle colorectal distension bilateral intrahippocampal injections cnqx ampar inhibitor expressions hippocampal ampars glur glur determined western blot results ibs like rats showed visceral hypersensitivity compared controls bilateral intrahippocampal injections cnqx alleviated visceral pain ibs like rats maximal effect appeared time point min duration lasted min cnqx application mmhg crd expressions hippocampal glur significantly increased ibs like rats compared controls however levels hippocampal glur significant differences rats hippocampal ltp induced hfs significantly enhanced compared controls expressions glur significantly increased control ibs like rats min ltp recordings glur conclusion neonatal maternal separation enhances expression glur facilitates ltp hippocampus could lead formation visceral hypersensitivity grown
background systemic autoinflammatory diseases saids represent growing number monogenic polygenic multifactorial disorders often difficult diagnose case presentation report patient initially erroneously diagnosed treated said symptoms consisted recurrent fever erythematous blistering skin lesions angioedema susceptibility bleeding external ear infections reversible anisocoria absence laboratory evidence systemic inflammation two half years extensive diagnostic work multiple empirical therapies final diagnosis munchausen proxy syndrome mbps established conclusions diagnosis said needs carefully reassessed measurable systemic inflammation missing mbps included differential diagnosis
self discrimination crucial mechanism social cognition neuroimaging neurostimulation research pointed involvement right temporoparietal region variety self discrimination tasks although repetitive transcranial magnetic stimulation right temporoparietal area shown disrupt self discrimination face recognition tasks research investigated effect increasing cortical excitability region self face discrimination used transcranial direct current stimulation tdcs investigate changes self discrimination video morphing task participant face morphed familiar face task performed min tdcs targeting right temporoparietal area anodal cathodal sham stimulation differences task performance following stimulation taken indicate change self discrimination following anodal stimulation observed significant increase amount self face needed distinguish self findings discussed relation control self representations domain general theories social cognition
background childhood acute lymphoblastic leukemia current cure rates reaching emphasizes necessity determine treatment related long term effects aim study estimate prevalence overweight obesity hepatic late adverse effects cohort survivors treated hematology oncology unit pediatrics department menoufia university egypt methods case control study height weight body mass index bmi assessed pediatric survivors healthy children parameters plotted growth standard deviation charts males females overweight obesity defined bmi percentile respectively laboratory investigations done form iron profile liver enzymes total direct bilirubin levels serum urea creatinine detection hepatitis virus antibodies elisa results weight bmi significantly greater survivors controls value respectively alt total direct bilirubin serum ferritin transferrin saturation considerably higher survivors controls value respectively ten survivors hepatitis antibodies none controls value conclusions pediatric survivors increased risk overweight obesity hepatic dysfunction form elevated liver enzymes bilirubin levels viral hepatitis screening survivors complications considered
introducing national green buildings paper analyzes measurable technology method target land efficiency outer environment green buildings design time practical examples including residential building public building introduced method land efficiency outer environment put forward experiments reference development green building country
bisphenol bpa widely used chemical production many polycarbonate plastics epoxy resin linings food beverage containers thermal papers oral intakes contaminated diets considered predominant source bpa exposure humans however due high levels bpa thermal receipts wide applications daily life amount bpa transferred skin holding thermal paper underestimated particularly cashiers investigate contribution bpa exposure levels via dermal contact route relationship bpa exposure level oxidative dna damage six male volunteers recruited required simulate cashiers work handle thermal receipts study period triclosan tcs antimicrobial compound used widely personal health skin care products applied reference compound urinary bpa tcs hydroxy deoxyguanosine ohdg concentrations determined high performance liquid chromatography tandem spectrometer results showed handling thermal receipts urinary bpa concentrations volunteers increased times experimental period tcs levels urine kept stable existed correlation bpa exposure ohdg tcs ohdg concentrations indicating bpa exposure could lead higher oxidative dna damage increases ohdg levels urine almost consistent bpa suggested handling thermal receipts resulted increasing bpa intakes bpa exposure correlated dna oxidative damage end handling thermal receipts urinary bpa levels descend levels experiment suggesting excretion bpa via dermal contact bpa exposure dermal contact route contributed urinary bpa levels gmratio cashiers indicating might seriously underestimated cashiers according previous studies attentions paid exposure bpa via dermal penetration cashiers elsevier ltd rights reserved
world ageing poses challenge produce cost effective solutions keep elderly people independent active assisting daily living activities regard paper presents new control method provide physical assistance user joints hip knee elbow etc needed wearer means assistive non medical single joint exoskeleton harmonized controller capable providing assistance natural way varying assistance needed user performing activity control method aimed exoskeletons provide assistance users facing difficulty activity walking sit stand etc providing assistance needed also reduce muscular effort completely healthy user harmonized control uses exoskeleton integrated force sensors motion sensors identify user intentions assistance level required generating appropriate control signals actuators implementing simple pid controller verify proposed harmonized control technique simulations using matlab simulink performed single joint system experimental test rig single joint also developed using matlab xpc target real time control user tests also carried knee joint results obtained simulations experimentation user tests reported discussed results achieved date reported show harmonized control promising user centric solution development single joint assistive exoskeletons support needed user daily living activities
solar energy storage medium moderate high temperature molten chlorate severally corrodes metal vessels corrosion behavior mechanisms pure nickel molten eutectic nacl mgcl studied initial stage corrosion pure gain weight many plate like shells formed sample surface corrosion sample surfaces rather porous loosened mgo nuclei attached loosened microstructure surface fell microstructures led continual decrease sample weight three sample surfaces mainly composed mgo sample substrate preferentially oxidized stably excited surface inhibits corrosion process corrosion rate highest delta phase rich phase boundaries corroded preferentially anode reaction metal atoms escape corrosion system form chlorides aqueous chlorides
considering limited turndown potential gasification technologies supplementing fuel cell turbine hybrid power system natural gas provides flexibility could improve economic viability dynamic characterization fuel composition transients essential first step completing system identification required controls development work open loop closed loop transient responses fuel cell solid oxide fuel cell sofc gas turbine hybrid system fuel composition changes experimentally investigated using cyber physical fuel cell system transition methane lean syngas methane rich gases turbine speed control studied distributed performance fuel cell analyzed detail temporal spatial resolution across cell dramatic changes fuel cell system post combustor thermal output thermal effluent resulting anode composition changes drove turbine transients caused significant cathode airflow fluctuations much less minute comparing open loop responses identical tests conducted closed loop conditions without significant airflow changes discovered cathode airflow change major linking event short term system transient response results suggested modulating cathode air flow response fuel composition changes offers promise dynamic control sofc hybrid systems fuel flexibility elsevier ltd rights reserved
previous work shows suicide rates increase economic recessions little research examined extent foreclosure crisis unique aspect great recession contributed disparities rising suicide rates race sex develop test two competing hypotheses regarding association foreclosures race sex specific suicide rates link foreclosure data realtytrac suicide data cdc metropolitan areas msa year observations find net time invariant unobserved metro area differences national time trends time varying confounders rise foreclosure rate associated marginal increase suicide main effect masks considerable heterogeneity across groups association particularly strong white males weaker non existent race sex groups elsevier ltd rights reserved
though many people impressions stem qualities obvious apparent social perceptions also rely variety subtle cues guide judgment behavior example emerging work increasingly elucidated conditions means individuals accuracy judging others sexual orientation better chance discuss focusing four domains people draw cues accurately perceive sexual orientation people adorn adornment move actions sound acoustics look appearance moreover describe certain factors one sexual orientation constrain facilitate accuracy describe various negative social occupational consequences may result cues someone gay straight
light emitting diodes leds continue penetrate global market pervasiveness clearly felt diverse fields technological socio economic commercial interests themulti billion dollar led market shared various segments including office household lighting street lighting automobile industry traffic signals backlighting hand held devices indoor outdoor signs indicators medicine communication systems crop cultivation using artificial light many technological development leds undergone many phases different parts world early discovery luminescence invention highly efficient organic leds researchers worked prime purpose improving performance luminaires need infuse market efficient cheaper products prevalent start leds result uncontrolled desire researchers develop superior products would displace existing products market understand led current prominence leds give brief historical overview field followed thorough discussion positive features leds work includes basic requirements advantages disadvantages leds variety applications brief description diverse applications led fields lighting indicators displays farming medicine communication given considerable importance placed discussing possible difficulties must overcome using leds commercial applications copyright john wiley sons ltd
article examine possible advantages apply discovery learning first programming computer course systems engineering practical sessions methodology framed educational research qualitative character based multiple cases study data collected practical sessions opinion students observation advances resolution computational problems results show significant meaningful learning taking previous knowledge possibility inferring new knowledge way methodology brings academic independence motivation students access another learnings courses studies
circum hellas area mars borders hellas planitia giant impact similar old making deepest broadest depression mars characterized complex pattern fracture sets lobate scarps grabens volcanic plains numerous lobate scarps circum hellas region mainly formed late noachian except amenthes rupes scarcely studied work study mechanical behavior thermal structure crust circum hellas region time lobate scarp formation modeling depth faulting beneath several prominent lobate scarps obtain faulting depths similar depending lobate scarp accounting uncertainty results indicate low surface mantle heat flows noachian early hesperian times agreement heat flow estimates derived lithospheric strength several regions similar age mars also faulting depth associate heat flows dependent local crustal thickness supports stratified crust circum hellas region heat producing elements concentrated upper layer thinner whole crust elsevier inc rights reserved
maze puzzle usually one user research adopted network technology develop maze game called multi maze allows multiple players competing across network concurrently contains three sub systems maze editor capable building degrees multi component maze supporting automatic semi automatic manual construction maze contour maze configured freely process building maze recorded replaying maze runner supports single user multi user mode multi user mode teammates communicate multi view display real time chats foot prints marks flags used avoiding repeated movements maze shown wall channel map maze manager allows editing upload download grouping teams coding multi maze two important utility tools developed multi view graph library network communication module formulas calculating coordination different degrees presented algorithms spanning tree used building perfect maze adding deleting walls allow maze separated components forming circuits state diagrams data structures class hierarchies presented related application projects
prior research shown background music may effective reducing problem behaviors maintained non social sensory reinforcement children autism spectrum disorders asd however study examined effects background music socially reinforced problem behaviors also common population thus purpose study extend previous research examining effects background music engagement problem behaviors maintained social reinforcement children asd following music preference assessment functional analysis used alternating treatment design examine effects background music problem behaviors three children asd background music produced clear reductions problem behaviors one participant marginal reductions second participant albeit preliminarily results indicate background music may reduce engagement problem behaviors maintained access socially mediated reinforcers
related temporal data play important role many applications clifford approach milestone model semantics temporal relational databases several relational representation models related data presented however semantics representations explicitly studied additionally definition relational algebra query related data open problem propose first integrated approach provides neat semantics related data compact representation data model relational algebra additionally approach also extends current approaches consider domains always possible know changes world recorded database related data bound persistency future explicitly model notion temporal indeterminacy future related data properties approach also analyzed theoretical semantic correctness reducibility algebra experimental point view experiments show despite fact approach major extension current temporal relational approaches significant overhead added deal
letter novel pass network implementation proposed using distributed lumped elements high group delay implementation reduced footprint sensitivity group delay performance specified component value tolerances experimentally verified measured group delay ghz thrice reported approaches circuit finds varied applications high resolution analog signal processing
study applied social cognitive models aggression order examine relations video game use aggressive tendencies biases social information processing end secondary school students aged completed survey two occasions one year apart hierarchical regression analysis probed media effects selection effects included relevant contextual variables parental monitoring media consumption impulsivity victimization results revealed consumption violent video games rather uncontrolled pattern video game use associated increasing aggressive tendencies increase partly mediated hostile attribution bias social information processing influence aggressive tendencies later video game consumption also examined selection path adolescents aggressive traits intensified video game behavior terms uncontrolled video game use found even controlling sensation seeking parental media control
embodiment become central topic ritual studies recent decades great deal changed comprehension ritual nature main characteristics knowledge become benefit liturgy research interpreting ritual based understanding physical acts gestures attitudes also find dimensions expressed liturgy term attitudes physical mental well occurrences deep embodiment attitudes liturgy signification liturgy takes place something verbal way nonverbal communication often dealt however reflected liturgy science text aims analysis certain approaches help understanding nature liturgical act always essentially ritual act
paper presents integrated maximum power point tracking system use thermophotovoltaic portable power generator design implemented cmos technology consists low power control stage boost power stage soft switching capability nominal input voltage output voltage demonstrate peak conversion efficiency nominal conditions overall peak efficiency power level control stage uses lossless current sensing together custom low power time based analogto digital converter minimize control losses converter employs fully integrated digital implementation peak power tracking algorithm achieves measured tracking efficiency detailed study achievable efficiency versus inductor size also presented calculated measured results
equal access autism services remains suboptimal diverse groups canada little known barriers immigrant mothers face accessing services support children developmental disabilities qualitative study immigrant mothers children autism diverse ethno cultural background interviewed toronto canada apply house four domains social support analyze findings structural support challenges delays diagnosis fragmented dispersed services common followed instrumental challenges due loss social ties stigma lack expected support partners negative perceptions services identified emotional perceptive challenges focused attention required address inequalities within context current access pathways autism
campylobacter concisus bacterium associated inflammatory bowel disease ibd immunosuppressive drugs including azathioprine aza mercaptopurine anti inflammatory drug aminosalicylic acid asa commonly used treat patients ibd study aimed examine effects aza asa growth ibd associated bacterial species identify bacterial enzymes involved immunosuppressive drug metabolism total bacterial strains five species including concisus strains bacteroides fragilis bacteroides vulgatus enterococcus faecalis escherichia coli examined impact aza asa growth bacterial species examined quantitatively using plate counting method presence enzymes involved aza metabolism bacterial species identified using bioinformatics tools aza significantly inhibited growth concisus strains concisus strains sensitive aza asa showed inhibitory effects concisus strains promoted growth concisus strains aza also significantly inhibited growth fragilis vulgatus growth coli significantly inhibited aza well asa bacterial enzymes related aza metabolism found varied different bacterial species conclusion aza inhibitory effects ibd associated concisus enteric microbes suggesting additional therapeutic mechanism drugs treatment ibd strain dependent differential impact asa growth concisus may also clinical implication given cases asa medications found cause exacerbations colitis
introduction atopic dermatitis recurrent chronic condition associated microorganism interaction susceptible host malassezia yeast known commensal thought provoke recurrent episodes symptoms atopic dermatitis patients malassezia immunomodulatory properties along defective skin barrier host results disease manifestation studied single nucleotide polymorphism snp ifn gamma genes host relation susceptibility malassezia infection aim isolate malassezia yeast patients compare genetic susceptibility host correlating cytokine gene polymorphism control subjects materials methods study conducted january january prospective observational study done department microbiology department dermatology venereology university college medical sciences gtb hospital delhi sample size comprised cases skin scrapings used fungal culture sabouraud dextrose agar sda modified dixon agar mda isolated identified per conventional phenotypic methods genomic dna extracted blood samples collected study subjects cytokine genotyping carried amplification refractory mutations systempolymerase chain reaction arms pcr sequence specific primers three snps gamma two cytokine genes assessed patients healthy controls statistical analysis chi square test fisher exact test bonferroni correction results group malassezia yeasts cultured samples thus identification rate percent compared healthy group percent significant difference allele genotype distribution observed ifn gamma gene polymorphism group conclusion higher isolation rate cases compared control group highlights implication malassezia association specific cytokine gene poly morphism clinical outcome found significant study group result cytokine gene polymorphism present study demonstrated susceptibility host malassezia infection
design agricultural machine highly complex process due interactions operator machine environment mountain coffee plantations constitute economic sector requires huge investments development agricultural machinery improve harvesting post harvesting processes overcome scarcity work forces fields aim study develop preliminary design virtual prototype coffee fruit harvester study project methodology applied adapted development following steps project planning informational design conceptual design preliminary design construction morphological matrix made possible obtain list different mechanisms specific functions union mechanisms resulted variants weighed attribute scores selected criterion designated proposal two variants best scores selected permitted preparation preliminary design variants archetype divided two parts namely hydraulically articulated arms harvesting system consisted vibration mechanism detachment mechanism proposed innovation involves use parallel rods fixed plane rectangular metal sheet step dimensions including maximum length minimum length total height identified based functioning harvester relation coupling point tractor
venomous animals developed huge arsenal reticulated peptides defense predation based various scaffolds represent colossal pharmacological diversity making top candidates development innovative drugs instead relying classical low throughput bioassay guided approach identify innovative bioactive peptides work exploits recent paradigm access venom diversity strategy bypasses classical approach combining high throughput transcriptomics proteomics bioinformatics cutting edge technologies generate reliable peptide sequences strategy employed generate hundreds reliable sequences conus venoms deeply described study led discovery conotoxins belong known pharmacological families targeting various gpcrs ion gated channels new families conotoxins never described date also focusses diversity genes sequences folds ptm provided species elsevier ltd rights reserved
analyse accuracy maxillary positioning fort osteotomy retrospectively assessed outcome three patients mean range age years treated patient specific cad cam osteosynthesis plates part bimaxillary osteotomy virtual surgical planning case based cone beam computed tomography simplant dentsply implants kessel belgium patient specific cad cam drilling guides osteosynthesis plates produced maxillary positioning fixation evaluated accuracy placement virtual comparison preoperative postoperative images upper dentition postoperative analysis showed mean deviation preoperative plan method enables accurate placement maxilla independent condyle mandible without need extraoral reference points published elsevier ltd behalf british association oral maxillofacial surgeons
sancho reservoir located odiel river basin crosses iberian pyrite belt reservoir receives acid mine drainage amd meca river tributary odiel river two multi parameter probes one placed tail gradient end reservoir contaminants enter another close reservoir dam used characterize acidity migration sancho reservoir probes measured conductivity every min two different levels contamination found due dilution takes place within reservoir changes amd composition cross correlation function allowed quantification migration process tail dam conductivity maximum correlation occurred days sampling indicating mean transit time days since distance two sampling points contaminant transit speed
paper authors present energy production potential mechanically resonant electrical generator system makes use natural human walking movements characteristics associated human walk discussed first followed electromechanical modeling approach employed choice electromechanical architecture justified permanent magnet moving coil structure modeled optimized demonstration device also generated tested order validate concept developed well theoretical models derived
present digital signal processing system based photon counting approach developed thermal neutron detector consisting zns lif scintillating layers read wls fibers sipms three digital filters evaluated moving sum moving sum differentiation digital filter performances detector filters presented full analog signal processing using filter emulated digitally detector performance obtained analog approach compared one obtained best performing digital approach elsevier rights reserved
objective polymorphisms adam gene implicated susceptibility risk childhood asthma however results remain controversial performed meta analyses clarify relationship methods relevant articles searched pubmed embase wanfang china national knowledge infrastructure odds ratio confidence interval used assess strength associations results fourteen studies five adam polymorphisms identified involving cases controls adam polymorphisms showed significant associations asthma risks overall caucasian children asian children caucasian chinese children respectively however significant results unstable sensitivity analysis revealed significant stable associations asthma risks among asian children dominant codominant models cumulative meta analyses significant results robust concerning polymorphism significant associations observed conclusion findings demonstrate adam polymorphism might potential susceptible predictor asthma asian children functional studies polymorphism asthma risks warranted
high quality services wired wireless networks require high bitrate network content delivery multipath transport protocols utilize multiple paths support increased throughput network applications ubiquitous mobile devices multiple interfaces wifi cellular data centers supporting big data analysis cloud computing motivate adoption multipath transmission current future network architectures congestion control mechanisms play fundamental role multipath transport protocols diverse approaches proposed literature differing terms goals principles performance mostly various issues addressed design paper presents survey congestion control solutions multipath transport protocols discusses multipath congestion control design order address need desirable properties including tcp friendliness load balancing stability pareto optimality existing window based rate based multipath congestion control algorithms investigated categorized based theoretical algorithm design next paper discusses congestion control mechanisms used diverse multipath transport protocols context different network scenarios finally trends future multipath congestion control design presented
lithium ion ion battery packs recovered end life electric vehicles present potential technological economic environmental opportunities improving energy systems material efficiency battery packs reused stationary applications part smart grid example provide energy storage systems ess load leveling residential commercial power previous work battery reuse demonstrated technical viability shown energy efficiency benefits energy storage systems modeled commercial scenarios current analysis performs life cycle assessment lca study ion battery pack used reused stationary ess complex functional unit used combine energy delivered battery pack mobility function stationary ess various scenarios cascaded mobility plus reuse stationary clean electric power scenarios contrasted conventional system mobility internal combustion engine vehicles plus natural gas peaking power eight years assumed first use years reuse stationary application operational scenarios environmental data based real time day time year power use additional data lca databases utilized ontario canada used geographic baseline analysis includes sensitivity electricity mix battery degradation seven environmental categories assessed using recipe results indicate manufacturing phase ion battery still dominate environmental impacts across extended life cycle pack first use vehicle plus reuse stationary application impact categories cascaded use system appears significantly beneficial compared conventional system consuming clean energy sources use reuse global local environmental stress reductions supported greenhouse gas advantages vehicle electrification doubled extending life batteries enabling better use peak low cost clean electricity intermittent renewable capacity however questions remain concerning implications long duration use raw material resources employed potential recycling ion battery packs present opportunities powering mobility stationary applications necessary transition cleaner energy battery state health considerable determinant life cycle performance ion battery pack use complex functional unit demonstrated studying component system multiple uses cascaded application
knowledge management within companies institutions one main problems defining developing new solutions improve information systems currently information systems evolved technological ecosystems set different components related information flows physical environment supports flows users part ecosystem particularly last several years open source software used develop technological solutions aim paper formalize architectural pattern support right description implementation elearning ecosystems theoretical basis provided previous works using comparative analysis strengths weaknesses opportunities threats several real case studies developed different contexts problems detected previous analysis modelled using business process model notation next pattern formalized service oriented architecture modelling language finally pattern tested real context namely institutional development spanish public administration demonstrated pattern works properly result obtained set business process model notation diagrams provide high abstraction level main detected problems elearning ecosystems also obtained architectural pattern composed several layers set external elements provides solution problems elsevier rights reserved
background gavi recommends solar refrigerators vaccine storage areas less eight hours electricity per day guidelines conservative question remains solar refrigerators provide value electrical outages less frequent methods using hermes generated computational model mozambique routine immunization supply chain simulated use solar versus electric mains powered refrigerators hereafter referred electric refrigerators different locations supply chain various circumstances results current price premium annual cost solar refrigerator electric refrigerator district level health facilities solar refrigerators provided savings electric refrigerators one day electrical outages occurred five times per year either district level health facilities even electric refrigerator holdover time exceeded duration outage two day outages occurring three times per year district level twice per year health facilities also caused solar refrigerators cost saving lowering annual cost solar refrigerator electric refrigerator allowed solar refrigerators cost saving either level one day outages occurred per year two day outages occurred per year district level even per year health facilities conclusion study supports gavi guidelines fact solar refrigerators may provide savings total cost per dose administered electrical refrigerators electrical outages less frequent study identified frequency duration electrical outages need occur solar refrigerators provide savings total cost per dose administered electric refrigerators different solar refrigerator prices published elsevier ltd
continuous growth internet things recent years meant increasingly present internet things scenarios smart homes smart cities become part everyday lives internet things devices involved divided two categories internet things scenarios devices constitute black box specific sensors complicates configuration example wearable products internet things devices composed configurable microcontrollers enabling customizable environments designed however necessary tools knowledge programming configuring microcontrollers accessible everyone article proposes run time deployment management system constrained application protocol bridges gap end users customizable environments system end users incorporate new sensors actuators installed microcontroller without access program microcontroller board rather manage resources constrained application protocol servers accessible transparent web user interface
objectivedetermine whether elimination pain improves accuracy clinical diagnostic criteria adult chronic rhinosinusitis study designretrospective cohort study methodshistory symptoms nasal endoscopy computed tomography results analyzed adults referred academic otolaryngology clinic presumptive diagnosis chronic rhinosinusitis clinical diagnosis rendered using rhinosinusitis taskforce rstf guidelines modified version eliminating facial pain ear pain dental pain headache resultsfour hundred seventy nine subjects met inclusion criteria among subjects positive rstf guidelines lacked objective evidence sinonasal inflammation endoscopy either modality applying modified rstf diagnostic criteria lacked sinonasal inflammation endoscopy either modality using either abnormal endoscopy reference standard modified diagnostic criteria yielded statistically significant increase specificity nonsignificant decrease sensitivity analysis comorbidities revealed temporomandibular joint disorder chronic cervical pain depression anxiety psychiatric medication use negatively associated objective inflammation endoscopy conclusionclinical diagnostic criteria overestimate prevalence chronic rhinosinusitis removing facial pain ear pain dental pain headache increased specificity without concordant loss sensitivity given high prevalence sinusitis improved clinical diagnostic criteria may assist primary care providers accurately predicting presence inflammation thereby reducing inappropriate antibiotic use delayed referral evaluation primary headache syndromes level evidence laryngoscope
purpose paper provide novel model characterize nonlinear restoring force marine vertical riser using position velocity dependent polynomials model permits obtaining specific state space representation via lienard transformation design state observers identify structural parameters vertical risers main results presented approximation nonlinear restoring force means polynomials incorporation distributed parameter model transformation model lienard system iii analysis observability identifiability properties
resonant converters used coil drivers inductive links generally operate efficiently optimum switching conditions constant load values ranges changes load range shift operation coil driver nonoptimum switching state results higher switching losses reduced output power levels paper presents method adapt variations range class inverter used coil driver wireless power transfer wpt system based inductive coupling shown controlling duty cycle inverter switch value feed inductance class inverter tuned operate optimum switching conditions distance coils wpt system changes mathematical analysis presented based linear piecewise state space representation inverter inductive link extensive experimental results presented verify performed analysis validity proposed tuning procedure
production planning models achieving interest used primary sector economy proposed model relies formulation location model representing set farms susceptible selected grocery shop brand supply local fresh products seasonal contracts main aim minimize overall procurement costs meet future demand kind problem rather common fresh vegetable supply chains producers located proximity either processing plants retailers proposed two stage stochastic model determines suppliers selected production contracts ensure high quality products minimal time farm table moreover lagrangian relaxation parallel computing algorithms proposed solve instances efficiently reasonable computational time results obtained show computational gains algorithmic proposals front usage plain cplex solver furthermore results ensure competitive advantages using proposed model purchase managers fresh vegetables industry
objective recognizing state art regarding care skin newborns method integrative literature review search studies performed medline lilacs bdenf databases studies published selected results indicated variety orientations may used health professionals care skin newborns frequently addressed topics causes lesions nursing care prevention lesions appropriate handling newborn infant assessment skin prevention transepidermal water loss body temperature regulation use emollients antiseptics bath dressings fixation devices prevention pressure ulcers care measures toward punctures treatment lesions conclusion study allowed updating subject enabling humanized individualized qualified care ensures safety neonatal patient
purpose purpose paper examine impact first generation peer mentoring experiences retention grade point average students perception academic leadership development design methodology approach study utilized mixed methods approach focus groups interviews utilized determine reported leadership experiences mentors descriptive statistics used compare grade point averages retention rates findings study found peer mentors residential life perceived increase leadership skills including role modeling time management personal confidence problem solving peers challenged roles perceived challenges help grow leaders compared peers peer mentors experienced increased retention similar grade point averages results indicated peer mentoring experiences beneficial mentors first generation college students even experiences particularly challenging research limitations implications biggest limitation study fact small sample without control group limitation difficult get students participate study future research might examine peer mentoring experiences first generation students larger campuses multiple campuses allow control group first generation peers without peer mentoring experience practical implications results indicated peer mentoring experiences beneficial mentors first generation college students even experiences particularly challenging social implications due potential success types experiences expanded first generation students group higher risk drop special attention paid ongoing training peer mentoring experiences given level commitment mentors originality value studies examined impact peer mentoring mentored examined impact experience mentors study extends research looking first generation college students valuable first generation students continue lag success college practical research improve student experience group necessary
developing cost efficient electrocatalysts oxygen evolution vital viability energy generated via electrolytic water engineering favorable defects electrocatalysts provide accessible active sites boost sluggish reaction thermodynamics kinetics herein nanosheets designed grown reduced graphene oxide rgo controlling successive two step hydrothermal reaction belt like cobalt based precursor first formed assistance ammonia rgo sulfurized cysteine higher hydrothermal temperature non stoichiometric defects ultrathin sheet like structure additional cobalt vacancies formed exposed catalyst surface expedited charge diffusion increased electroactive surface contact electrolyte resulting rgo hybrids exhibited overpotential low alkaline electrolyte oxygen evolution reaction oer density functional theory calculations indicated rgo hybrid functioned catalytic sites enhanced oer also reduced energy barrier transformation intermediate oxygenated species promoting oer thermodynamics
introduction aim investigate rate vascular dementia dementia women previous hypertensive disorders pregnancy since white matter lesions brain cardiovascular disease linked dementia hypertensive disorders pregnancy material methods prospective population based registry study women giving birth sweden women without hypertensive disorders pregnancy identified means swedish medical birth register linked national patient register data somatic disease later life obtained international classification disease used cox proportional hazard model used calculate hazard ratios groups adjusted possible confounders main outcome measures hospital diagnosis cardiovascular disease vascular dementia dementia results increased risks seen vascular dementia dementia hypertensive disorders pregnancy broken specific diagnoses hypertensive disease pregnancy adjusted risks vascular dementia hypertension proteinuria pregnancy hazard ratio higher risks cardiovascular disease confirmed conclusions low absolute risk wide confidence interval risk misclassification results vascular dementia could questioned considering pathophysiology preeclampsia findings brain lesions increased risk cardiovascular disease possibly increased risk kinds dementia must investigated larger well defined cohorts
population growth urbanization pollution climate change pose urgent water challenges cities study sustainability integrated water resources management chi minh city hcmc evaluated using city blueprint approach city blueprint set dedicated indicators divided categories water security water quality drinking water sanitation infrastructure climate robustness biodiversity attractiveness governance including public participation analysis showed rapid increase water use urban industrial agricultural activities hcmc resulted depletion groundwater severe pollution groundwater surface water surface water quality groundwater quality biodiversity sanitation domestic industrial wastewater matters need serious improvement current future water supply hcmc risk hcmc cope governance gaps described organisation economic operation development oecd major obstacles hcmc rainwater harvesting pollution reduction well wastewater reuse among practical options wastewater reuse could lower water stress index window narrow rapidly closing result unprecedented urbanization economic growth region integr environ assess manag setac
designall project hardware software architecture development implementation adaptable adaptive applications aimed support people carrying independent life home paper problems interactions applications implemented android platform chosen experiments interaction developed applications discussed main emphasis two main aspects use facilities supporting accessibility available commonly used operating systems mainstreaming portability solutions across different platforms
restoration adequate water supply spring prerequisite survival angiosperm trees temperate regions trees must establish access soil water recover xylem functionality thus hypothesized prolonged soil frost impairs recovery affects hydraulics phenology malus domestica var golden delicious test hypothesis two consecutive winters soil around trees insulated prolong soil frosting mid winter early summer level native embolism water starch contents wood bark buds quantified regular intervals findings correlated various phenological parameters xylogenesis fine root growth findings confirm prolonged soil frost affects tree hydraulics phenology severity effect depends climatic conditions study years percentage loss hydraulic conductivity plc decreased end winter may thereby xylem refilling strongly coincided decrease starch wood bark also treated trees able restore hydraulic system may warm spring xylem refilling increases water content starch depolymerization delayed contrast cold spring small differences control treated trees observed prolongation soil frost also led delay phenology xylogenesis fine root growth conclude reduced water uptake frozen cold soils impairs refilling thus negatively impacts tree hydraulics growth apple trees spring unfavorable circumstances may cause severe winter damage even dieback
expansive soils one problematic materials widely encountered significant land areas several parts world like africa australia india united states canada south gujarat region india majority top soil black cotton soil black cotton soil characteristics shrinking drying heaving wetting soil expansive creates several types damages pavement structures cases pavement may even become unserviceable normal climate condition study area shows short wet long dry period aggravate problem swelling shrinkage irc annexure suggest thick non cohesive soil cushion expansive soil road construction led higher cost road construction also new urban areas difficult raise embankment excavate subgrade upto depth due existing structures laying service lines provide economical solution along feasible application two innovative materials used namely consolid geotextile flexible pavement consolid application shows great improvement cbr values helping overall stability pavement geotextile provided pavement components act heaving swelling soil time helps drainage layer also field study undertaken observe effect geotextile flexible pavement performance specific boundary conditions created observations observations shows reduction shrinkage effect paved road reinforced geotextile subjected drying wetting cycles materials unique advantage performance improvement flexible pavement expansive subgrade
background female sex workers fsws extremely vulnerable adverse sexual reproductive health srh outcomes mitigate risks require access services covering hiv prevention also contraception cervical cancer screening sexual violence develop context specific intervention packages improve uptake identified gaps service utilization four different cities methods cross sectional survey conducted part baseline assessment implementation research project fwss recruited durban south africa mombasa kenya mysore india tete mozambique using respondent driven sampling rds starting seeds identified peer educators fsws responded standardised interviewer administered questionnaire use contraceptive methods services cervical cancer screening sexual violence unwanted pregnancies rds adjusted proportions surrounding confidence intervals estimated non parametric bootstrapping compared across cities using post hoc pairwise comparison tests dunn sidak correction results current use modern contraception ranged tete mombasa non barrier contraception hormonal iud sterilisation varied durban mysore ever used emergency contraception ranged mysore mombasa ever screened cervical cancer tete durban gone health facility termination unwanted pregnancy durban mysore sought medical care forced sex varied mombasa mysore many differences cities remained statistically significant adjusting variations fsws sociodemographic characteristics conclusion use srh commodities services fsws often low highly context specific reasons variation across cities need explored differences unlikely caused differences socio demographic characteristics probably stem differences availability accessibility srh services intervention packages improve use contraceptives srh services tailored particular gaps city
paper variable selection random forests algorithm presence correlated predictors high dimensional regression classification frameworks variable selection difficult task becomes even challenging presence highly correlated predictors firstly provide theoretical study permutation importance measure additive regression model allows describe correlation predictors impacts permutation importance results motivate use recursive feature elimination rfe algorithm variable selection context algorithm recursively eliminates variables using permutation importance measure ranking criterion next various simulation experiments illustrate efficiency rfe algorithm selecting small number variables together good prediction error finally selection algorithm tested landsat satellite data uci machine learning repository
purpose review injectable contraception highly effective form birth control globally popular recent research focused ways make injectables depot medroxyprogesterone acetate dmpa accessible improve side effect profile injectables review focus new directions approaches use injectable contraception recent findings research area injectable contraception focused improving access women home self injection also task shifting community based distribution low resource areas specific dmpa studies focused lowering overall dose medication maintaining efficacy improving drug delivery systems research association dmpa hiv needed also effects administration dmpa time medication abortion summary injectable contraceptives important part global method mix highly effective birth control improving accessibility side effect profile commodities dmpa make injectables even valuable women seeking effective contraception
work presents development piezocomposites made macro fiber composites mfcs aerospace applications specifically involves computational analysis material characterization certain parametric studies mfc developed nasa langley research center currently distributed smart material worldwide finds applications actuator well sensor various engineering applications work mfc modeled actuator theoretical formulation based variational asymptotic method vam presented analyse laminates made mfcs vam minimizes total electro mechanical energy mfc laminate approaches exact solution asymptotically making use certain small parameters inherent problem dimensional reduction vam provides closed form solutions constitutive law recovery relations warpings stress strain fields displacements hence ideal tool carrying parametric design studies applications vam geometrically exact offers rigorous material characterization cross sectional analysis dimensional reduction
land subsidence caused mining activities example human transformation natural environment leads changes land use study covers area silesian upland southern poland records period document presence subsidence effects study area maximum displacement figure translates average rate per year found subsidence basins serve new local erosion base new sedimentation basins filled sediments whose level pollution ranges moderate heavy extremely heavy subsidence caused dramatic change local hydrology including quality quantity water specifics involve emergence new closed drainage catchments total area increase total watercourse length increase river network density decrease number increase area lakes ponds increase lake coverage ratio water pollution subsidence limited potential land uses led decrease arable land gave way land uses including equivalent wasteland copyright john wiley sons ltd
paper introduces basic concept fuzzy pid manufacturing engineering system temperature control analyzed temperature designed correction factor optimized parameters application fuzzy general matlab simulink toolbox temperature designed comparing fuzzy pid output raditional output system characteristic quick response short setting time small overshoots high control precision
present paper deals problem characterization oscillating magnetic dipole omd signals development suitable magnetic anomaly detection mad algorithm resulting outcomes investigating mentioned problem development complete model noise signal based non linear gravity pendulum model model compared verified real world magnetic signals well simulated ones detection algorithm utilizes model whitening noise seeking periodical features signal developed algorithm high noise immunity high detection probabilities even low snr compared benchmark detectors detection scheme offers performance improved moreover testing detector real world signals snr difference respect performance predicted simulations less
self anchored suspension bridge large span arrangement designed urban railway city chongjin china deck system bridge also special features rubber layer concrete slabs orthotropic steel deck used absorb vibration energy order study fatigue behaviour orthotropic steel deck finite element model established weld rib diaphragm region modelled oblique shell element reference stress defined stress influence lines details calculated stress ranges counted rain flow method nominal stress method adopted assess fatigue behaviour concerned part apart circle form cut compared key form used bridge due stress dispersing concrete slab results show stress ranges keep relatively low level details two cut forms key form cut eventually adopted easy assemble ribs diaphragms relatively large weld tolerance authors published elsevier ltd
distributed denial service ddos attacks always remain problematic security data centers malicious codes injected weaker network acquire unauthorized access protection firewalls initial line defense battle unauthorized access help flawless transactions conventional firewalls rely predefined policies control policies rely assumptions notions firewalls much intelligent take run time decision last minute required however hacker continuously stroke port firewall hang slowdown responding moreover chance access servers entire network survey based state art data centers especially ddos challenges dcns paper based learning processes focus evaluate analyse complexity secure connections real world data centers
biosimilar infliximab inx recently approved european medicine agency treatment rheumatoid arthritis ankylosing spondylitis crohn disease ulcerative colitis psoriatic arthritis psa psoriasis grounds pharmacokinetics safety efficacy comparable innovator inx aim study investigate real life efficacy safety immunogenicity switching innovator biosimilar inx patients spondyloarthritis spa forty one patients attending three italian rheumatology centres previous diagnosis spa clinically inactive moderate disease activity asdas crp five enteropathic arthritis psa four undifferentiated spa treated months innovator inx accordance asas eular guidelines switched biosimilar inx pharmaco economic reasons tuscany law april followed months record kept basdai basfi asdas crp das crp presence peripheral disease mases vas pain scores duration morning stiffness adverse events aes time switch patients median age years range median disease duration months range median duration treatment innovator inx months range months biosimilar inx therapy statistical differences median basdai basfi asdas crp das crp mases vas pain scores whereas median duration morning stiffness significantly decreased furthermore change circulating inx anti inx antibody levels switch innovator biosimilar inx italian multicentre spa cohort associated statistically significance differences efficacy adverse events anti drug antibody level
due historical nature data warehouses require large volumes data need stored repositories organizations beginning problems manage analyze huge volumes data due large part relational databases primary method data storage data warehouse start underperforming crumbling weight data stored opposition systems arise nosql databases associated storage large volumes data inherent big data paradigm thus article focuses study feasibility implications adoption nosql database within data warehousing context mongodb selected represent nosql systems investigation paper explained processes required design structure data warehouse typically dimensional queries mongodb system undertaken research culminates performance analysis queries executed traditional data warehouse based sql server system equivalent data warehouse based mongodb system
objective evaluate knowledge caregivers identification changes skin elderly care consider correct situations methods descriptive study caregivers patients treated university hospital federal district used pre post test questions type cause treatment common skin disorders elderly results sample caregivers women average age years old children elderly reported course caregiver pre test damage recognized diaper area dermatitis post test improvement recognition items correct answers conclusion results showed injuries known caregivers part day day care elderly easy recognized educational guidance carried becomes effective method identify lesions
approximately half people psychotic disorders schizophrenia group also develop comorbid addictive disorder lifetime called dual diagnosis patients difficult treat poor compliance frequent relapses often present aggressive behavior towards others long term sociorehabilitative outcomes poor article different models understanding high comorbidity psychoses substance use disorders explained principles integrated treatment patients outlined low threshold motivational integrated treatment programs psychoeducative behavioral therapeutic elements helpful extensively implemented however long term treatment methods needed therapeutic goals must realistic set high
objective objective study assess effect insurance type medicaid medicare private insurance cash pay patients access psychiatrists new patient consultation method psychiatrists identified interested treating patients ptsd called across states caller requested appointment fictitious boyfriend car accident evaluated ptsd office called four times assess responses payment type call whether appointment offered barriers appointment recorded results psychiatrists would see new patients offices scheduled appointment patient medicaid compared medicare bluecross cash pay medicaid patients confronted barriers receiving appointments trouble scheduling appointments states expanded medicaid eligibility overall number ofmedicaid patients would able theoretically schedule appointment states versus states without expanded medicaid eligibility approximately equivalent psychiatry practice characteristics aswhether practicewas academic significantly associated acceptance medicaid conclusions access psychiatrist new patient consultation challenging despite expansion affordable care act substantial barriers remain medicaid patients accessing psychiatric care compared patients medicare private insurance pay cash elsevier inc rights reserved
conjugated microporous poly benzothiadiazole hereafter denoted bbt synthesized palladium catalyzed sonogashira hagihara cross coupling polycondensation used novel organic semiconductor photocatalyst photocatalytic production pollutant degradation visible light lambda irradiation furthermore bbt tio heterojunction conveniently fabricated situ polycondensation procedure dibromobenzo thiadiazole triethynylbenzene presence commercial tio optimizing composition ratio resultant bbt tio heterojunction exhibited dramatically enhanced visible light responsive photocatalytic activities similar times higher activity evolution ciprofloxacin degradation respectively compared bbt alone detailed investigations revealed bbt tio heterojunction interface accelerate photogenerated electron transferring bbt tio improve photoactivity present work exhibits interesting points dramatic improvement photoactivity organic semiconductor combined inorganic one provides novel direction exploit fabricate photocatalyst solar energy conversion pollutant degradation elsevier rights reserved
model voltage source inverter depends output filter parameters filter differ significantly nominal values due power losses core output coil changes inductance multi input single output control systems effectively reduce inverter output voltage distortions standard nonlinear rectifier load however design requires knowledge actual values inverter parameters novelty paper connects designs two miso control systems method automated measurements voltage source inverter parameters breadboard verification also included
pregnant smokers may benefit digital smoking cessation interventions designed population aim transparently report development smartphone app designed aid smoking cessation pregnancy development smartphone app smokefree baby help pregnant women stop smoking guided frameworks developing complex interventions including medical research council mrc multiphase optimization strategy behaviour change wheel bcw two integrative behaviour change theories provided theoretical base evidence scientific literature behaviour change techniques bcts bct taxonomy informed intervention content app developed around five core modules distinct intervention target identity change stress management health information promoting use face face support behavioural substitution available control full version smokefree baby developed part multiphase intervention optimization identify optimum combination intervention components include smartphone apps help pregnant smokers stop smoking
non suicidal self injury nssi highly prevalent adolescence suggested autonomous diagnosis diagnostic statistical manual dsm social rejection potential risk factor nssi depression adolescence objectives study identify differences neural processing social rejection depressed adolescents without morbid nssi healthy controls participants depressed adolescents morbid nssi females healthy controls average age years social exclusion implemented using cyberball paradigm cyberball functional magnetic resonance imaging fmri participants reported feelings social exclusion fmri scanning investigating effects nssi found depressed adolescents nssi showed relatively enhanced activation medial prefrontal cortex mpfc ventrolateral prefrontal cortex vipfc compared depressed adolescents without nssi also compared healthy controls results point towards divergent processing social exclusion depressed adolescents nssi compared adolescents mere depression brain regions previously related processing social exclusion finding distinct neurophysiological responses may stimulate research individual treatment approaches authors published elsevier ireland ltd
paper describes general design considerations analysis industrial size electro static motor generator operation fundamentals combined finite element analysis discussed target operation outer space vacuumed environment torque production limitations high voltage electric field analyzed compared conventional frame size electric machines
background annually children traumatic brain injury tbi admitted emergency depathuent netherlands presentation varies specific entity comprises juvenile head trauma syndrome jhts secondary deterioration mild trauma outcome jhts fatal early recognition essential aim outline epidemiology clinical features jhts comparison paediatric mild tbi patients without jhts methods retrospective study patients mild tbi admitted level one trauma centre diagnosis jhts experienced neurologists compared diagnosis physicians results physicians diagnosed jhts frequently compared experienced neurologists jhts occurred lucid interval varying min mean changes consciousness jhts patients younger compared mild tbi patients range years falls occurred often jhts presentation vomiting changed behaviour present compared mild tbi group conclusion discussion jhts occurs often children years falls major cause injury clues recognition syndrome comprise changes consciousness vomiting changed behaviour presentation clinical practice factors guide decision hospital admission discharge european paediatric neurology society published elsevier ltd rights reserved
backgroundthe psychosis pathway introduced london child adolescent mental health service camhs aim identify manage ultra high risk psychosis uhr methoda service evaluation conducted review clinical impact arm psychosis pathway year period resultswe found decreased time psychiatric review reduction dup reduced inpatient admissions therefore reduction morbidity transition rate uhr psychotic illness years conclusionthere much utility identifying managing uhr camhs settings
background objective acute respiratory failure arf patients interstitial lung disease ild associated significant morbidity mortality recommended assessment acute exacerbation ild includes exclusion secondary causes via fibreoptic bronchoscopy aim assess role bronchoscopy arf ild methods consecutive ild patients hospitalized arf underwent bronchoscopy included baseline demographics underlying ild diagnoses presenting clinical features reviewed characteristics bronchoscopy including diagnostic findings management complications collated results one hundred six patients accounted unique bronchoscopies sixteen abnormal infections haemorrhages baseline presenting clinical features differ without abnormal findings half performed intensive care unit icu bronchoscopies performed general floor setting resulting icu transfer resulted immediate mechanical ventilation overall management arf positive bronchoscopy findings similar without resulting similar hospital mortality conclusion bronchoscopy clinical assessment arf ild often performed yield large retrospective cohort management inhospital mortality similar routine diagnostic bronchoscopy arf ild studied given low yield high procedural risk
determination partial discharges inception voltage pdiv different configurations electrical motors essential ensure sizing choose right electrical insulation system standard ieee suggests using motorette measurements performed model show good reproducibility results non impregnated impregnated motorettes determinations pdiv also done using paschen law modified dunbar pdiv resulting experimental measurements good accordance obtained modeling
brazilian jiu jitsu bjj grappling combat sport athletes lying guard fighter kneeling pass fighter mat attempt force opponents submit brazilian jiu jitsu practices may result muscular imbalances increase risk injury instead functional movement screen fms evaluation routine could related injury incidence seeks detect muscular imbalance movement dysfunction thus aim study investigate injury profile fms score relationship consideration bjj fight style sports injuries recorded last months bjj athletes statistical analyses applied routine evaluation fms score points less considered low performance fms used logistic regression effect size calculated assumed statistical significance level pass fighters showed higher percentage injuries thorax guard fighters upper limbs injured part body chi injuries occurred training sessions chi despite lack statistical differences fms performance guard pass fighters magnitude considered medium association fms presence injury chi considering fms score predictor presence absence injury dependent variable data met wald coefficient exp study found almost half sample injuries upper limbs quarter injuries lower limbs last year poor fms score observed lower scores fms associated higher risk injury bjj athletes
hepatitis virus hcv infects hepatocytes binding heparan sulfate proteoglycans particular syndecan followed recognition tetraspanin receptors heparan sulfate proteoglycans found specific microenvironment coating hepatocyte surface called glycocalyx receptors extracellular matrix proteins cytokines growth factors lipoproteins infectious agents investigated mutual influence hcv infection glycocalyx revealed new links syndecan hepatocyte infection hcv inhibited knocking syndecan xylosyltransferase key enzyme syndecan biosynthesis simultaneous knockdown syndecan strongly inhibited infection suggesting cooperative action early infection stages syndecan virions colocalized plasma membrane internalized endosomes direct interactions syndecan revealed primary transformed hepatocytes immunoprecipitation proximity ligation assays expression syndecan xylosyltransferase altered within days post infection remaining syndecan pool colocalized poorly data indicate profound reshuffling hepatocyte glycocalyx hcv infection possibly required establishing optimal conditions viral propagation
problem faces many countries including united states finance retirement consumption population ages proposals switching saving retirement system rely high payroll taxes challenged grounds welfare would fall groups retirees working poor show devise transition path current system saving retirement system increases welfare current future generations estimates future gains higher found typically used macroeconomic models gains large productive capital commonly assumed quantitative results depend importantly accounting differences actual government tax revenues revenues would income taxed income weighted average marginal tax rates used analysis
report case year patient treated anoperineal crohn disease corticosteroids mercaptopurine azathioprine inducing prolonged remission patient evolution marked fast deterioration general health status morphological examination favor severe outbreak disease diagnosis fistulizing anoperineal crohn disease made patient treated broad spectrum antibiotics parenteral feeding digestive system rest defunctioning colostomy allowing clinical improvement treated anti tnf alpha infliximab dosage patient evolution complicated gradual onset tumor like anal lesion progressively increasing volume associated fast deterioration general health status new abdominal mri allowed detect anorectal tumoral process immunohistochimically favor infiltrating ano rectal adenocarcinoma cases anorectal adenocarcinoma associated fistulizing crohn disease reported study aimed attentively analyse possible malignant transformation fistulizing crohn disease patient treated infliximab highlight role histological assessment anal perineal lesion treatment anti tnf therapy diagnosis difficult due inflammatory status concomitant stenosis imaging tests including scan mri appear low sensitivity detecting cancer
study investigated processes pathways leadership development teachers different career stages participated professional development program multiple case study approach conceptual frameworks teacher leadership practice identity used leadership development process across three teachers involved alignment synergy among leadership views leadership practices identity however particular pathways leadership development unique teacher depending upon personal priorities school context prior life experiences study contributes literature documenting teachers develop teacher leaders elsevier ltd rights reserved
chalcopyrite copper indium sulfide cuins cis bandgap optimal solar energy conversion material paper used polymer type ion release source control precursor concentration hydrothermal system grow cis nanowires analytical results indicate reaction process based formation cus binary compound followed indium intercalation induces formation cis chalcopyrite crystal structure products characterized ray diffraction scanning electron microscopy transmission electron microscopy cis nanowires diameter length
purpose management fracture nonunion challenging another surgical intervention patient often necessity huge impact quality life economic burden patient thus less aggressive better accepted treatment nonunion required methods gave teriparatide year old man femoral fracture nonunion year underwent surgery autogenous bone grafting failed heal initial nonunion successful union obtained daily administration teriparatide months results case showed teriparatide could successfully treat femoral fracture nonunion autogenous bone grafting failed heal conclusions teriparatide may provide alternative treatment fracture nonunion
background purpose study perform histological comparative analysis tibiotalar joint samples taken areas osteolysis adjacent total ankle arthroplasties control synovial specimens determine reaction presence polyethylene particles methods total pathology samples identified osteolysis group identified control group sample hematoxylin eosin oil red oro macrophage marker stained slides created polarized light oro stain used identify particles presence metal particles giant cell reaction particles also scored results macrophages particles metallosis foreign body giant cell reaction scores significantly higher osteolysis group compared control group osteolysis group oro staining positive birefringent material present macrophage infiltrates present foreign body giant cell reaction giant cells surrounding particles present osteolytic specimens presence foreign body giant cell reaction associated significantly higher macrophage oro polarizable material scores average time surgery osteolysis index ankle replacement range years patients osteolysis group conclusion study largest ankle arthroplasty histological analysis show areas osteolysis consist abundant polyethylene wear particles present intracellularly extracellularly furthermore areas associated macrophage infiltrate frequently foreign body reaction giant cells engulfing particles likely implant wear particles play significant role osteolysis based histopathology level evidence level iii retrospective comparative series
achieve competitive advantages companies need embrace changes evolve strategies coping challenges time data limited study applies grey forecast theory lotka volterra competition model explore dynamic competition smart tvs flat panel tvs well android ios smartphone operating systems results show growing strength smart tvs android superior competing products respect interactive relationship products two aforementioned products represent competition relationship predators prey flat panel tvs ios playing role prey smart tvs android predators comparing forecast accuracy among model proposed study grey forecasting model lotka volterra model found proposed model best accuracy companies use proposed model develop strategic plan feasible enough secure sustainable competitive advantage elsevier inc rights reserved
electromagnetic interference emi shielding reduced graphene oxide mrg doped mrg bmrg doped mrg mrg doped mrg mrg studied band frequency range ghz developed green fast cost effective microwave assisted route synthesis doped mrg mrg shows high electrical conductivity comparison mrg mrg mrg results better electromagnetic interference emi shielding ability doping significantly enhances electrical conductivity mrg introduces electrons provides holes system may form nanojunction inside material temperature dependent electrical conductivity follows variable range hopping vrh efros shldovskii vrh vrh conduction model low temperature range spatial configuration mrg doping enhances space charge polarization natural resonance dielectric polarization trapping waves internal reflection leading high emi shielding attenuation compared undoped critical thickness results suggest mrg great potential candidate new type emi shielding material useful aircraft defense industries communication systems stealth technology
turbine engines provide challenging environment materials temperature environment stress time durations components exposed tremendous turbine engines like energy power generation systems ever pushed increase performance fuel efficiency continued drive requiring engine architecture associated materials changes meet need increase capability materials asked provide increased temperature capabilities support enhanced engine cycles time required lighter weight increased operational speeds engine performance likewise advances materials materials processing may enable components reduced engine part count designed efficiently convert fuel thrust challenges requiring new materials new novel approaches apply existing materials approach taken meet challenges integration materials processes design functions integration material manufacturing process design efforts seamlessly component design processes requires new tools methods integrated computational materials engineering icme providing path holistic linking material process component design optimization materials models providing enhanced materials design definitions enabling greater physics based understanding fundamental behavior materials compilations materials process models effectively map genome materials greatly expand ability component designer fully utilize capabilities engineered materials whether emerging new materials existing materials approach integrated materials process design engineering path enable major changes future advanced turbine systems tools methods already made significant impact current emerging engine systems
one largest threats future development climate change apparently building sector largest source greenhouse gas production one prospective solution green building aims provide environmentally sustainable building terms design construction maintenance however green buildings symbolize next stage buildings recent growth new green building constructions inadequate overcome negative impact existing buildings one logical solution reduce environmental impact existing buildings green retrofitting yet lack systematic review existing body knowledge green retrofitting critical future research paper aims critically review existing literature green retrofitting identify contemporary research trends additionally view current challenges barriers obstacles problems green retrofitting study highlights needs identify critical success factors csfs successful implementation green retrofit projects
paper presents signal processing method uses digital pulse intermediate signal delta sigma analog digital conversion unlike conventional analog signal processing directly uses voltage variables amplifier based transconductor based filters method proposed work converts voltage variables digital pulse allows charge pump implemented loop filters thus removes analog building blocks mentioned method circumventing conventional analog building blocks may lead lower power consumption favor cmos technologies scaling example fourth order delta sigma modulator based proposed method presented behavioral simulation results show performance proposed modulator comparable original modulator
article conceptual design architecture broadband vibration based nonlinear energy harvester reported non linear behavior functionality presented compared provided conventional linear beam type energy harvesters nonlinear harvester provide widen resonance frequency ranges hence collect vibration energy generated various dominant rotational frequencies rotary machine smart material called magneto rheological elastomer mre added usual beam structured energy harvester since mre one magnetic smart materials stiffness tuned precisely controlling applied magnetic field stiffness combined piezoelectric beam mre becomes adjustable adjustable stiffness resonance frequency new beam type energy harvester adaptively changed match particular dominant rotational frequency generated monitored machine maximum vibration energy harvested moreover due nonlinearity new composite beam structure range resonance frequency range widened make easier adapt slightly varying dominant rotational frequency due monitored machine small speed variation besides presentation design architecture article simulated experimental results new non linear harvester also reported comparison study bandwidth output power generated new nonlinear energy harvester generated conventional harvester result shows new non linear harvester functioning superior conventional harvesters
supercritical fluid extraction sfe green technology used extraction bioactive compounds pigments fatty acids recent years naturally occurring plants plant based extracts considered potential candidates antioxidant antimicrobial activities therefore work range locally available natural plants oregano mexican arnica also known heterotheca inuloides lemon peel blackberry marc analyzed extraction high value compounds multivariable linear regression model used analyze output variables relation inputs pressure temperature solvent cos based arrhenius equation linear correlativity data activation energy mol pre exponential factor recorded thermodynamic parameters enthalpy entropy gibbs free energy also evaluated correlating thermodynamics extraction yield process elsevier rights reserved
well documented population growth development biological subsystems utilization resources ecology economy frequently follow logistic sigmoid time development context oil gas extraction development known hubbert peak oil theory observe logistic equation describes historic development nuclear hydroelectric energy production well previous studies hypothesized present time fastest growing renewable technologies wind solar energy develop similar constraints provide evidence installation technologies follow logistic curve contrast commonly perceived specific growth rate energy extraction wind turbines photovoltaics decreased recent years optimistic scenario included forecasted data solar wind associations four years future logistic model implies total installed capacity saturates around sharp contrast almost established belief energy technologies experience exponential growth far century
background liao river basin jilin province place origin dongliao river study gives comprehensive analysis vegetation coverage region provides potential theoretical basis ecological restoration methods seasonal variation vegetation greenness dynamics based normalized difference vegetation index ndvi major land cover types region studied analyzing relationship ndvi temperature rainfall derived set predictor variables using modis terra level product modqkm results results showed general increasing trend ndvi value region region showed degradation ndvi values begin rise april plants regreening drop september temperature decreasing leaves falling study area temperature found decreasing period rainfall showed increasing trend model could used observe change vegetation greenness dynamic effects temperature rainfall conclusion study provided important data environmental protection basin area hope provide scientific analysis controlling water soil erosion maintaining sustainable productivity land resources enhancing treatment water pollution stimulating virtuous cycle ecological system
letter illustrates general analytical method power converters called averaging binary tree structure representation proposed method based switching signal flow graph ssfg models describes converters binary tree structure general construction principles binary tree complex flow graph system summarized developed proposed method applied analysis second order converters shows advantages high convenience practicability compared conventional ssfg analytical methods simulation experimental observations provided validate proposed algorithm
examined claim autobiographical implicit association test aiat detect concealed memories subjects read action statements break toothpick either performed action completed math problems imagined actions new actions two weeks later subjects completed memory test aiat categorized true false statements front computer whether performed actions session half subjects nonperformed statements actions saw perform remaining subjects statements actions saw imagined perform results showed aiat distinguish true autobiographical events performed actions false events nonperformed actions less effective subjects remember performing actions really perform thus diagnosticity aiat may limited
configuration realization voltage mode second order filters employing single operational transresistance amplifier otra active element presented topology synthesize lowpass highpass bandpass notch allpass filtering functions presented filters suitable mos implementation yielding filter parameters electronically tunable theoretical analysis verified pspice simulation elsevier gmbh rights reserved
objective childhood maltreatment widely accepted risk factor drug addiction adolescence adulthood however influence childhood maltreatment drug treatment related variables drug abstinence motivation self concept well self efficacy remains unclear study aims exploring whether self concept mediates relationship childhood maltreatment abstinence motivation well self efficacy among drug addicts methods study involves males females mean age range years drug addicts compulsory detoxification units participants completed questionnaires including childhood trauma questionnaire item short form ctq tennessee self concept scale tscs general self efficacy scale gses drug abstinence motivation questionnaire damq results structural equation model sem analysis including total specific forms maltreatment scores showed childhood maltreatment negatively associated self concept self efficacy abstinence motivation self concept positively associated self efficacy abstinence motivation conversely significant association self efficacy abstinence motivation exist indirect analysis showed self concept mediated relationship childhood maltreatment self efficacy critically selfconcept arbitrated relationship childhood maltreatment abstinence motivation indirect effect self concept childhood maltreatment abstinence motivation still existed total scores maltreatment replaced scores specific forms maltreatment conclusions results demonstrated self concept critical factor understanding relationship childhood maltreatment abstinence motivation well self efficacy among drug addicts improving sense self worth may effective intervention therapy among drug addicts childhood maltreatment history elsevier ltd rights reserved
celebrated paper furst math syst theory furst saxe sipser used random restrictions reveal weakness boolean circuits bounded depth establishing constant depth polynomial size circuits compute parity function local restrictions played important roles found many applications complexity analysis algorithm design past three decades article give brief overview two intriguing applications local restrictions first one isomorphism conjecture second one moderately exponential time algorithms boolean formula satisfiability problem
thermal wave radar imaging twri developed detect manufacturing cracks automotive powder metallurgy components transmission sprockets green unsintered state crack detection capability twri phase validated two sets cracked crack free green sintered sprockets sectioned twri measurements automatic defect recognition adr twr image processing method also developed differentiate cracks local defects measurement results demonstrated twri superior conventional lock thermography imaging liti flaw detection resolution speed thus viable green sprocket manufacturing flaw imaging technology
radiation induced skin toxicity prevalent side effect radiation therapy significant effect patients quality life also results poor follow early termination radiotherapy treatment several skin care practices topical applications studied field radiodermatitis including skin washing topical steroids mechanical skin barriers aside methods many patients turn complementary alternative medicine prevention treatment radiodermatitis many alternative therapies topically applied antioxidants rationale behind use antioxidants treating radiodermatitis strong clinical studies far less consistent even large scale randomised controlled trials findings limited inconsistent use topical vehicles placebos article authors review role topical antioxidants better help practitioner navigate different available skin directed antioxidants
objectiveelectrical stimulation via implanted electrodes overlie cortex brain upcoming neurosurgical technique hindered long time insufficient knowledge brain functions dynamic physiological pathological way well technological limitations implantable stimulation devices methodsthis paper provides overview cortex stimulation via implantable devices introduces future possibilities improve cortex stimulation resultscortex stimulation initially used preoperatively technique localize functions brain later evolved treatment technique first used pain recently multitude pathologies targeted cortex stimulation disorders treated stimulating different cortical areas brain risks complications essentially similar related deep brain stimulation predominantly include haemorrhage seizures infection hardware failures cortex stimulation fully mature technological development required predict outcomes improve stimulation designs includes development network science based functional connectivity approaches genetic analyses development navigated high definition transcranial alternating current stimulation development pseudorandom stimulation designs preventing habituation conclusionin conclusion cortex stimulation nascent promising approach treating variety diseases requires technological development predicting outcomes network science based functional connectivity approaches genetic analyses development navigated transcranial electrical stimulation development pseudorandom stimulation designs preventing habituation
objective individuals schizophrenia demonstrate cognitive social cognitive motivational deficits contribute impairment real world functioning current study investigated effects supplementing computerized neurocognitive training social cognitive exercises compared neurocognitive training alone method ongoing double blind randomized controlled trial participants psychosis compare effects supplementing intensive targeted cognitive training social cognitive training exercises tct sct effects targeted cognitive training alone tct participants assessed cognition symptoms functional capacity functional outcomes well social cognition measures related reward processing results treatment groups showed significant improvement multiple cognitive domains improvement functional capacity however predicted tct sct group participants showed significant improvement prosody identification reward processing relative tct participants conclusions implications practice findings indicate supplementing intensive computerized cognitive training social cognitive exercises people psychosis confers greater benefits prosody identification reward processing relative cognitive training alone even though approaches drive significant improvements cognition functional capacity impairments prosody identification reward processing associated greater negative symptoms poorer functional outcomes schizophrenia raising possibility form treatment may lead better long term outcomes traditional cognitive training approaches follow assessments determine whether results durable generalize time improvements symptoms functioning
paper deals identification nonlinear vibration systems based measured signals free forced vibration regimes two categories time domain signal analyzed one fast inter modulation signal second composed several mono components extent attempts imitate analytic studies systems two major analysis groups perturbation harmonic balance methods two appropriate signal processing methods investigated one based demodulation signal decomposition hilbert transform shown enable effective simple methods analysis show precise identification nonlinear parameters obtained contrary average based methods approximation parameters obtained effectiveness proposed methods demonstrated precise nonlinear system identification using signal demodulation signal decomposition methods following exposition tools used signal demodulation well decomposition applied classical examples nonlinear systems cases nonlinear stiffness damping forces analyzed include among asymmetric helmholtz oscillator backlash nonlinear turbulent square friction duffing oscillator dry friction elsevier ltd rights reserved
article generalised nonlinear schrodinger maxwell bloch system investigated describes propagation optical solitons optical fibre doped two level resonant impurities like erbium fourth order dispersion taken account bilinear forms derived via hirota method symbolic computation auxiliary function bright solitons obtained complex envelope field measure polarisation resonant medium dark ones deduced extant population inversion propagation one two solitons analysed results solitons keep shapes unchanged interaction except phase shifts means interaction elastic velocities solitons decrease effect discreteness higher order dispersion increases bound state solitons formed among solitons velocity period decreases effect discreteness higher order dispersion increases
background translational researchers need robust solutions access range data types varying public data sets pseudonymised patient information restricted access provided case case basis reason complication managing access policies sensitive human data must consider issues data confidentiality identifiability extent consent data usage agreements ethical social legal aspects must incorporated differential management restricted access sensitive data methods paper present pilot system uses several common open source software components novel combination coordinate access heterogeneous biomedical data repositories containing open data open access well sensitive data restricted access domain biobanking biosample research approach based digital identity federation software manage resource access entitlements results open source software components assembled configured way allow different ways restricted access according protection needs data tested resulting pilot infrastructure assessed performance feasibility reproducibility conclusions common open source software components sufficient allow creation secure system differential access sensitive data implementation system exemplary researchers facing similar requirements restricted access data report experience lessons learnt pilot implementation may useful similar use cases furthermore discuss possible extensions complex scenarios
rationale little known residence rural farming environment allergic diseases latin america methods cross sectional study rural residence current wheeze current asthma current symptoms allergic rhino conjunctivitis adolescents ages years attending schools urban rural areas san francisco cordoba argentina rural residence classified never previous current duration rural residence categorized years current wheeze current asthma current allergic rhino conjunctivitis defined basis responses extensively validated questionnaire international study asthma allergies childhood logistic regression used multivariable analysis rural residence outcomes interest results adjustment current smoking covariates current rural residence odds ratio confidence interval rural residence years significantly associated reduced odds current wheeze multivariable analysis current residence rural area rural residence years significantly associated reduced odds allergic rhino conjunctivitis association longer significant additional adjustment current residence dairy farm significantly associated reduced odds allergic rhino conjunctivitis similarly current regular contact farm animals significantly associated reduced odds allergic rhino conjunctivitis conclusions among argentinean adolescents current rural residence rural residence years associated reduced odds current wheeze allergic rhino conjunctivitis potential protective effects may explained dairy farm environment including regular contact farm animals wiley periodicals inc
objectivethere evidence transgender people find aspects standards ofcare soc thehealth oftranssexual transgender andgendernonconformingpeople implementation health professionals problematic counterproductive transitioning study evaluated significance dissatisfaction transitioning mental health transgender people method self identified transgender people responded online survey assessed satisfaction health services provided accordance soc guidelines satisfaction health professionals assisting transition personal hardiness gender congruence steps transition depression anxiety stress resultsalthough results revealed dissatisfaction standards care health professionals particularly psychiatrists subsequent path analyses conducted via structural equation modelling failed reveal associations dissatisfaction factors relevant transitioning mental health however personal hardiness found associated greater progress transitioning way improved gender congruence self esteem mental health conclusionwhile results reveal dissatisfaction australian health system professionals appear translate poor mental health outcomes rather personal hardiness transition important predictor transitioning mental health argues greater emphasis placed building supporting personal resilience transgender people
growing number evidence suggests brain derived neurotrophic factor bdnf plays important part modulating activities basis hippocampus neural plasticity learning memory heroin addiction series cognitive impairments may associated bdnf study explored association bdnf cognitive function hero independent patients enrolled heroin dependent patients normal control subjects examined cognition repeatable battery assessment neuropsychological status rbans serum bdnf levels groups bdnf levels significantly higher patients controls cognitive scores rbans showed attention language index significantly lower heroin dependent patients control groups unfortunately found positive association bdnf cognitive function patients except bdnf positively associated visuospatial constructional index control groups findings suggest bdnf may involved pathophysiology heroin dependence studies cognitive impairment heroin addiction needed
inter turn short circuit itsc fault one typical fault different types magnetically coupled circuits transformers rotating linear electrical machines paper presents general study approach itsc understanding modeling long circuit represented state space equations itsc magnetically coupled windings accurately modelled means step autotransformer circuit faulty winding moreover considerations leakage inductances estimation studied generalized case study itsc proposed three phase squirrel cage induction machine representation system presented simulated matlab environment means ode simulink also equivalent circuits derived representation shown verification purposes finite element analysis fea experimental test conducted comparison proposed theoretical models simulations experimental results performed
although infrequent trypanosoma cruzi reactivation possible among patients hiv aids infection develop tumor like granulomatous lesion cns report case years old male patient hiv aids low lymphocytes count cerebellar symptoms mild paresis associated supra infratentorial hypodense lesions positive serology tests gondii trypanosoma cruzi empirical therapy toxoplasmosis prescribed together antiretroviral therapy without favorable response brain chagas disease confirmed quantitative pcr csf died despite nifurtimox treatment despite rare occurrence chagas disease affecting cns possible among patients hiv aids infection epidemiological exposure positive chagas serological test image pattern brain lesions support suspicion diagnosis confirmed molecular test csf samples including new quantitative methods despite adverse prognosis specific therapy attempted besides antiretroviral treatment
district heating stations heat carrier circulated energy source consumers pumping system fluid handling systems pumping systems responsible significant portion total electrical energy use significant opportunities exist reduce pumping energy smart design retrofitting operating practices existing systems requiring flow control make use bypass lines throttling valves pump speed adjustments efficient options pump speed control one issues using variable speed pumping systems however total efficiency electric motor pump arrangement given operating condition paper provides comprehensive discussion pump control heating stations analyzes energy efficiency flow control methods specific attention also given selection motor types sizing pump duty cycle comparative energy analysis performed hot water discharge adjustment using throttling control valves variable speed drives district heating station constructed romania correlate pumped flow rate heat demand ensure necessary pressure using minimum energy automatic system designed performances control methods evaluated two practical applications results show approximately total pumping energy could saved using optimal control method variable speed pumps additionally modernization solutions reduce environmental impact heating stations described
data systems typically categorized source truth systems serve primary stores user generated writes reads complex queries recent years scientists regularly encounter limitations due large data sets many areas especially query big data paper construct access aware memory data cache middleware aidcm relational databases integral part rdbms memory cache one hand aidcm provides low latency supporting log based trigger presence updates maintain data consistency hand aidcm translate frequently accessed data column oriented memory cache column access frequency ensure heavy hitter queries also present experimental results describe middleware supporting wide range applications big data
propose solve black oil reservoir optimal control problem direct multiple shooting method allows parallelization simulation time handling output constraints however requires continuity constraints state variables couple simulation intervals black oil fluid model considering volatile oil wet gas requires change primary variables simulation consequence absence fluid phase due dissolution vaporization therefore reservoir simulators parametrize states augmented vector select primary variables accordingly however augmented state vector corresponding change primary variables suitable application optimization problem formulation must change according change variables thus propose minimal state space variable representation prevents shortcoming show bijective mapping proposed state space representation augmented state space minimal representation used optimization augmented representation simulation thereby keeping simulator implementation unchanged therefore proposed solution invasive finally application method exemplified benchmark cases involving live oil wet gas examples emphasize requirement output constraints efficiently dealt method elsevier rights reserved
theophylline naturally alkaloid commonly employed treat asthma chronic obstructive pulmonary disorder herein facile theophylline assisted green approach firstly developed synthesis ptau nanospheres reduced graphene oxide ptau nssirgo without surfactant polymer seed involved obtained nanocomposites applied catalytic reduction removal highly toxic chromium using formic acid model reductant degrees showing significantly enhanced catalytic activity improved recyclability compared commercial home made nanocrystals supported rgo ncs rgo demonstrates great potential applications catalyst wastewater treatment environmental protection eco friendly route provides new platform fabricate catalysts enhanced catalytic activity elsevier inc rights reserved
artificial intelligence approach successfully applied wide range materials engineering problems far however work incorporation modeling algorithms based alto predict performance thermoelectric materials paper shows predict dimensionless thermoelectric figure merit xyxtio ceramics performance symbol structures using adaptive neuro fuzzy inference system anfis moreover work investigates effect process parameters including content compact pressure sintering temperature sintering time process temperature performance xyxtio thermoelectric ceramics absolute fraction variance root mean square error training testing phases model achieved showing relatively high accuracy proposed anfis model investigate effect synthesis method synthesis type xyxtio ceramics performance materials parameter also introduced model obtained results shown graphs interaction graphs process variables generated proposed model indicated combustion synthesis effective ones increase efficiency xyxtio thermoelectric ceramics elsevier ltd techna group rights reserved
mental health trial analyzed using dose response model number sessions attended patients deemed indicative dose psychotherapeutic treatment parameter interest difference causal treatment effects subpopulations take part different numbers therapy sessions data set interactions random treatment allocation prognostic baseline variables provide requisite instrumental variables corresponding two stage least squares tsls estimator tends smaller bias ordinary least squares ols estimator tsls suffers larger variance therefore appealing combine desirable properties ols tsls estimators trade achieved affine combination two estimators using mean squared error criterion produces semi parametric stein like spsl estimator introduced judge mittelhammer spsl estimator used conjunction multiple imputation chained equations provide estimator exploit available information simulated data also generated illustrate superiority spsl estimator ols tsls counterparts package entitled steiniv implementing methods made available platform authors statistics medicine published john wiley sons ltd
summary united states united kingdom supervisory neglect children premised construction childhood characterises children essentially vulnerable need constant care protection parents western conception transmitted countries sub sahara via convention rights child however socio economic cultural context african countries differs significantly united kingdom united states incorporation western hegemonic idea childhood national laws african countries creates fundamental contradictions application criteria adjudging adequacy parental supervision sub sahara drawing secondary data article explores contradictions proposes alternative considerations conceptualisation assessment supervisory neglect finding combined effects households sub sahara economic conditions ascribed gender roles reciprocal duties held children assist families contest established indicators thresholds supervisory neglect concept societal neglect together application haddon matrix provides apposite framework reducing risk significant harm children application african countries excepting somalia introduced convention rights child domestic legislation findings study pertinent policy makers social workers sub sahara also invite western scholars critically engage dominant notions supervisory neglect appraise applicability cross national contexts
reactive power compensation methods one effective methods improve efficiency energy systems therefore designs implementations systems important aim study design implement appropriate reactive power compensation systems electrical power systems reactive power compensation realized using capacitors synchronous motors study microcontroller computer controlled compensation applications done capacitors synchronous motors load conditions performed means designed system tried determine type reactive power compensation suitable existing system respect aimed avoid unnecessary investments existing systems establish quality compensation system addition designed system easy update kinds load changes require additional equipment
participatory rainwater harvesting promoting integrated development agri horti livestock cum pisciculture implemented high altitude msl areas mawlangkhar village west khasi hills district meghalaya watershed approach assess refine improved package practices integrating crops fruits vegetables fish animal production higher productivity income soil water conservation measures like construction renovation ponds jalkund micro rainwater harvesting structure hilltops bench half moon terraces developed active participation local peoples quantum water harvested one point time monsoon season two ponds community lands million litre water two ponds individual farmer land million litre water jalkunds million litre hill tops estimated million litre utilized multiple purposes including irrigation pisciculture livestocks domestic purpose cost water harvesting community pond computed sic litre jalkund sic litre considering lives pond jalkund least years respectively impact analysis revealed productivity gone potato rice introduction improved package practices various crops availability irrigation water integration different components farmers able get sic month community dairy unit individual farmer income piggery unit increased substantially ranged sic year besides farmers earning substantial income sic annum community pond composite pisciculuture therefore integrated watershed programme could considered successful model high altitude areas north east india similar ecosystems livelihood improvement resource poor tribal farmers
virtualization considered one core technologies cloud computing overcome low efficiency resource utilization physical machines multiplexing operating systems applications physical servers form virtual machine however efficient algorithm policy required order map virtual machines physical machines dynamically support efficient consolidation load balancing virtual machines addition server environment configured servers heterogeneous capabilities allocation algorithm mapping policy essential efficient server operations paper introduce efficient dynamic allocation algorithm virtual machines heterogeneous server environment works based accurate resource allocation priority previous methods proposed algorithm provides efficient allocation virtual machines based priority evaluation supports efficiency algorithm consolidation load balancing virtual machines heterogeneous server environment
adolescence time continued brain maturation particularly limbic cortical regions undoubtedly plays role physiological emotional changes prenatally stressed offspring rats used investigate potential antidepressive like effects imperatorin imp extracted root radix angelica weeks treatment imp behavioral tests sucrose preference test forced swimming test open field test measured hydroxytryptamine concentration hippocampus frontal cortex measured using enzyme linked immunosorbent assay serotonin transporters htt hta receptor htar mrna expression hippocampus frontal cortex also determined real time pcr administration imp day intragastrically days markedly increased percentage sucrose anhedonia decreased immobility time increased number total crossings center crossings rearing grooming male prenatally stressed offspring meanwhile found concentration hippocampus frontal cortex significantly increased imp treated group subsequently found significantly decreased htt increased htar mrna expressions hippocampus frontal cortex imp treatment prenatally stressed male offspring imp showed antidepressive like effects increased concentration male prenatally stressed offspring suggesting imp could therapeutic use preventing depressive like behavior adolescence copyright author published wolters kluwer health inc
ongoing research los alamos national laboratory studies earth radio frequency background utilizing satellite based observations terrestrial lightning impulsive events occur presence additive noise structured clutter appear broadband nonlinear chirps receiver orbit due ionospheric dispersion fast orbit recording transient events forte satellite provided rich lightning database application modern pattern recognition techniques database may lightning research potentially improve event discrimination capabilities future satellite payloads extend two established dictionary learning algorithms svd hebbian use classification satellite data algorithms allow learn features without relying analytical constraints additional knowledge expected signal characteristics use pursuit search learned dictionaries generate sparse classification features discuss performance terms event classification using nearest subspace classifier show use two dictionary types mixed implementation showcase algorithm distinctions extracting discriminative information use principal component analysis analyze compare learned dictionary spaces real data space discuss aspects computational complexity implementation authors published spie creative commons attribution unported license distribution reproduction work whole part requires full attribution original publication including doi
advances scientific techniques provided researchers exceptional new opportunities identify monitor changes different cancer types different stages progression individual tumor cells surrounding stroma wealth information obtained new scientific techniques places additional requirements conventional cancer models new models could used rapidly access potential functional importance newly identified epi genetic proteomic changes test efficacy emerging combinatorial therapies desperately required distinctive characteristics zebrafish progressively applied create relevant models human diseases zebrafish embryos provide powerful tool develop functional cancer models tool used drug discovery development assessment drug toxicity review summarise use zebrafish xenograft models study human cancers discuss benefits limitations models
paper deals synthesis active frequency filters oscillators applications video band synthesis based modified signal flow graph design approach current mode commercially available high frequency current conveyors second order structures used basic structure employing loss less lossy current mode integrators two distributed feedback loops used active elements allow control current gain useful applications high frequency multi functional filter electronically adjustable quadrature oscillator configurations discussed used passive elements mainly capacitors grounded suitable implementation simulation experimental results demonstrate function features well
find balance food energy security research presents design energy self sufficient farm electricity heat bioethanol produced energy crops agricultural residues farm proposed evaluated two models land optimization cost optimization due food fuel debate land detriment food security research proposes utilizing current abandoned land increasing food self sufficiency ratio fssr crops analyzed rice wheat maize farm optimized several food fuel demands maximum farm unit size result myriad farms different sizes optimized certain demand subsequently amount variety farms optimized maximizing food fuel produced city case study miyagi prefecture japan results suggest establishment energy self sufficient farms abandoned land stimulate biofuel industry increase food security simultaneously fssr maize wheat improved approximately respectively estimated bioethanol potential additionally surplus electricity heat approximately gwh respectively obtained land optimization model proposed sensitive crop yields simultaneous evaluation recommended results also suggest farms must larger achieve self sufficiency therefore policies involved need evaluation
psychopaths capacity moral action viewed philosophically interesting also important relevant policy philosophical discussion psychopathy focussed upon psychological faculties prerequisites moral responsibility empirical findings regarding psychopathy relevant philosophical accounts moral understanding motivation however legitimate worries whether psychopathy robust scientific construct risks attached reifying psychopathy psychiatric constructs defend concept psychopathy pointing relevance empirical studies ordinary practices ascribing moral responsibility folk psychological accounts moral understanding motivation
use polyacrylamide pam based flocculants become essential component geotextile tube dewatering projects although knowledge residual flocculant concentration geotextile tube supernatant effluent essential safe use pam based flocculants residual flocculant concentration commonly measured geotextile tube dewatering operations furthermore astm standard test method measuring residual flocculant concentrations water paper presents comparative study two different methods commonly used measure residual flocculant concentrations water streaming current detection scd method china clay settling rate ccsr method evaluate applicability geotextile tube industry comparison based analysis measured residual pam concentrations obtained five different cationic pam polymers used flocculate tully fines soil optimum flocculant doses tully fines soil determined using jar test astm three different solids concentrations mass scd ccsr methods performed supernatants tully fines conditioned optimum doses concentrations optimum dose laboratory test results showed scd ccsr methods produced similar residual pam concentration results polymer soil combinations tested scd method however produced consistent repeatable results comparison ccsr method scd method also easier use could performed shorter amounts time ccsr method based results recommended scd method standardized used measure residual pam based flocculant concentrations geotextile tube supernatant effluent
carbon nanofibers emerging smart material promising use biosensor biofuel cell transducer material due morphological electrochemical characteristics particular graphitized carbon nanofibers possess unique structures graphite like edges within high surface area provide large active site enzyme attachment specific application biofuel cell requires highly stable electrical communication electricity generation non covalent enzyme immobilization using bifunctional molecule suggested appropriate approach change carbon hybridization covalent immobilization acid treatment graphitized carbon nanofiber paper gcnfp electrode fabricated dispersion filtration method glucose oxidase model enzyme immobilized bifunctional molecule forms stacking pyrene moiety nanofiber wall coupled reactive end amine reaction system provides practical enzyme electrode hybrid facilitates comparatively faster enzyme electrode electrical communication system using similar material calculated heterogeneous electron transfer rate constant
present project possible prove relationship existing internal personality variables self concept pro sociality distal variables like physical activity academic achievement within school context promoting physical activity sport also means teenagers learn personal social competence allows offer educational tool develop pro social behavior descriptive project whose sample made secondary school students socio demographic questionnaire used self concept questionnaire scale pro sociality teenagers adults cantoblanco scale socialization difficulties soc different school qualifications among results obtained confirmed physical activity ones physical self concept improves turn leads better social perception thus integrating teenager peer groups resulting better academic results
present features results newly developed code based gauss newton optimization technique solving three dimensional controlled source electromagnetic inverse problem code special emphasis put representing operations block matrices conjugate gradient iteration show computation jacobian matrix formed differentiation system matrix made independent frequency optimize operations conjugate gradient step coarse level parallel computing using openmp framework used primarily due simplicity implementation accessibility shared memory multi core computing machine almost anyone demonstrate coarseness modeling grid comparison source comp utational receivers spacing exploited efficient computing without compromising quality inverted model reducing number adjoint calls also demonstrated adjoint field even computed grid coarser modeling grid without affecting inversion outcome observations reconfirmed using experiment design deviation source straight tow line considered finally real field data inversion experiment presented demonstrate robustness code elsevier rights reserved
paper deals localization problem mobile robot subject communication delay packet loss delay loss may appear random fashion control inputs observation measurements unified state space representation constructed describe mixed uncertainties based optimal linear estimator developed main idea derivation relevance factor incorporate delayed measurements estimate estimator extended nonlinear systems performance method tested within simulations matlab experiments real robot system good localization results prove efficiency method purpose localization networked mobile robot
visual presentation outputs marine mammal detectors key efficient mining large acoustic datasets operators must able easily navigate large time series detections examine spectrograms listen detected sounds validate compare detections different species time space jmesh web platform designed constraints mind interface organized around three interconnected visualization panels geographic interface displays maps showing total number detections species monitoring locations within adjustable time period detection time series plot displays temporal variations detections several species selected monitoring location multimedia panel allows user visualize spectrograms listen sounds validate detections three panels interactive allow user navigate intuitively platform uses load balancing microservices orchestration shared non relational databases virtualization technologies make infrastructure fully scalable expandable single server resource farm composed hundreds hosts jmesh display detections archived data real time acquisition systems compatibility mobile devices bootstrap framework simplifies access data field
memristor regarded new fourth fundamental circuit element many also considered analog applications expected analog filters memristors provide characteristics mimicked resistors study memristor based low pass high pass filters analyzed performance demonstrated simulations time frequency domains saturation memristor memristor based filters low frequencies distortion resulting observed also gain total harmonic distortion filters function frequency given results obtained work used design memristor based low pass high pass filters
background asymptomatic carotid artery stenosis acas marker cerebrovascular disease coronary atherosclerosis death aim investigate prevalence acas indian population correlate acas vascular risk factors materials methods prospectively recruited individuals older years asymptomatic cerebrovascular disease june december evaluation vascular risk factors done participants color doppler bilateral carotid arteries performed participants carotid stenosis considered mild significant stenosis respectively results men mean age years age range years prevalence significant carotid stenosis adjustment using multiple regression analysis age years hypertension diabetes smoking dyslipidemia history migraine history periodontitis family history stroke significantly associated stenosis duration years hypertension diabetes smoking markedly worsened risk year follow participants mild stenosis participants significant stenosis developed stroke conclusions study suggests asymptomatic individuals years age harbor significant extracranial carotid artery disease presence multiple vascular risk factors markedly increases risk carotid stenosis
new products usually offer advantages existing products health care new drugs comparable effectiveness side effects existing drugs ambiguous evidence base around adverse effects despite new treatments drive increased health care spending suggesting preference newness setting explore whether preferences treatments labeled new exist persist ambiguity evidence base reflecting newness described use canadian general population sample characterized innovativeness adopting new products normal markets found innovators early adopters significant preferences newer treatments irrespective comparable benefits side effects respondents significant preferences less ambiguity benefit side effect estimates notably newness combined ambiguity significant preferences new treatments observed regardless respondent innovativeness conclude preferences new products exist people health care markets disappear implication ambiguity evidence base new treatments communicated physicians avoid describing treatments new mindful qualify implications new treatments terms evidence ambiguity copyright john wiley sons ltd
although might believed eye comprised small area face injury due ball impacts different sports seems severe enough entice many researchers determine level injury attempt minimize sports related eye injuries especially tennis pose substantial preventable problem eye due high speed tennis ball many ophthalmologists provide wide range information patients regarding risks eye injuries tennis prevent injury well eyes year however far although general information regarding injury human eye components due tennis ball impact details stresses deformations well determined therefore goal study determine stresses deformations eye components including cornea aqueous body iris ciliary body lens vitreous body retina sclera optic nerve extra intraconal fats muscles attributable tennis ball impact via lagrangian eulerian computational coupling model magnetic resonance imaging employed establish finite element model human eye according normal human eye numerical results revealed highest amount stress iris mpa whereas lowest one observed vitreous body cornea also experienced stress mpa might high enough invoke rupture delicate material addition results exhibited decreasing increasing radius curvature cornea lens respectively finally collision tennis ball eye triggered resultant displacement optic nerve may imply non significant injury findings study may implications understating values stresses deformations human eye components also helping ophthalmologists precise diagnosis injury position eye due tennis ball impact
internet things trust establishment plays important role improving cooperation enhancing security evaluate trust relationships among sensor nodes accurately appropriate trust estimation model designed attack misbehavior effectively paper novel quantitative model trust value proposed variety trust factors related behaviors sensor nodes measured including packet forwarding capacity repetition rate consistency packet content delay integrity etc void impact subjective setting trust factor determined means information entropy theory addition theory adopted deduce synthesize trust statistic factor nodes behavior introduced modify synthesis result evaluation results show scheme performs better defeating attacks
using detailed building simulation model amount thermal buffering without phase change material pcm needed time shift air source heat pump operation peak periods defined economy tariff investigated typical detached dwelling performance buffered system compared case load shifting thermal buffering additionally load shifting population buffered heat pumps peak periods simulated resulting change peak demand electricity network assessed results study indicate hot water buffering pcm enhanced hot water buffering required move operation heat pump fully peak periods without adversely affecting provision space heating hot water end user work also highlights buffering load shifting increased heat pump electrical demand leading increased cost end user increased emissions depending electricity tariff applied time varying intensity electricity generation mix respectively study also highlights load shifting populations buffered heat pumps wholly peak periods using crude instruments tariffs increased peak loading electrical network rather reducing careful consideration needed load shifting group heat pumps orchestrated elsevier ltd rights reserved
background negative mental imagery ubiquitous cognitive models social anxiety social anxiety literature previous research shown causal increased anxiety lower social performance ratings lower implicit self esteem despite prevalence studies investigated imagery directly aims study aimed provide depth analysis phenomenology negative imagery experienced socially anxious individuals compare recurrent intrusive images images deliberately generated participants study method thirty eight undergraduate students screened average social anxiety scores completed computerized imagery questionnaire adapted previous qualitative work results thematic analyses revealed four major image themes intrusive images three deliberately generated images including interacting others anxiety symptoms intrusive images based negative episodic memories experienced least fortnightly images primarily visual auditory somatic could involve sensory modality depression anxiety stress scale dass scores higher participants experienced intrusive imagery increased frequency intrusions emotionality generally higher intrusive images generated images conclusions phenomenology negative imagery experienced socially anxious individuals idiosyncratic may inherently different images generated use experimental research theoretical clinical implications discussed
office women health funded five pilot healthy weight intervention studies lesbian bisexual women included program called strong healthy energized session program targeted toward women age older focused exercise including pedometer track steps nutrition stress management group discussions program enrolled participants waist circumference decreased across group participants lowest one third baseline step count saw marked step increase intervention effective improving health behaviors short term health outcomes older women
background aims sofosbuvir sof weight based ribarivin rbv represented recently standard care hepatitis virus hcv genotype patients registration studies weeks duration associated sustained virological response weeks svr real life cohorts showed lower svr rates methods svr rates attained italian real life cohort possible benefits duration extended weeks investigated hcv patients cirrhosis role chimeras potential predictor treatment failure also analysed results overall hcv infected patients bridging fibrosis cirrhosis evaluated median age years treatment naive cirrhotic patients child pugh score platelets count albumin svr overall non cirrhotic patients cirrhotic patients patients completed treatment svr rates cirrhotic patients resulted weeks respectively predictors svr low platelet count esophageal varices respectively anemia mild moderate severe cases anemia slightly frequent among longer duration associated treatment discontinuations strains genotypes different baseline identified relapse conclusions cirrhotic patients sof rbv weeks associated real life svr rates lay summary duration treatment weeks recommended treatment hcv patients using combination sofosbuvir ribavirin real life experiences patients received weeks treatment regardless severity liver disease suggested response rates lower expected particular patients liver cirrhosis misleading genotyping strain also hypothesized explanation less effectiveness demonstrated using recommended extended duration patients severe disease patients severe liver disease including cirrhosis cured strain plays secondary role specific countries like germany although combination recently replaced sofosbuvir velpatasvir fixed dose combination standard care treating hcv patients findings may inform physicians countries new regimen yet available european association study liver published elsevier rights reserved
ambient assisted living facilitate optimum health wellness aiding physical mental social well paper patients psychiatric symptoms collected lightweight biosensors web based psychiatric screening scales smart home environment analyzed machine learning algorithms provide ambient intelligence psychiatric emergency psychiatric states modeled hidden markov model hmm model parameters estimated using viterbi path counting scalable stochastic variational inference svi based training algorithm likely psychiatric state sequence corresponding observation sequence determined emergency psychiatric state predicted proposed algorithm moreover enable personalized psychiatric emergency care service web objects based framework proposed smart home environment framework biosensor observations psychiatric rating scales objectified virtualized web space web objects sensor observations psychiatric rating scores used assess dweller mental health status predict emergency psychiatric state proposed psychiatric state prediction algorithm reported percent prediction accuracy empirical performance study
malaysia aims developed state various programs policies towards promulgated development rapidly arising result nevertheless vital need balance development sustainability water resources malaysia important water demand steadily increasing country industrialized highly populated cities significant water resources managed efficiently water conservation efforts rainwater harvesting promoted across country paper aims examine development policies may affect sustainability water resources implementation legal point view doctrinal study involves analyses related laws development policies impact development process paper concludes although important laws policies introduced implementation hindered lack support stakeholders lack integration water agencies copyright john wiley sons ltd erp environment
new vision sensors dynamic active pixel vision sensor davis incorporate conventional global shutter camera event based sensor pixel array sensors great potential high speed robotics computer vision allow combine benefits conventional cameras event based sensors low latency high temporal resolution high dynamic range however new algorithms required exploit sensor characteristics cope unconventional output consists stream asynchronous brightness changes called events synchronous grayscale frames purpose present release collection datasets captured davis variety synthetic real environments hope motivate research new algorithms high speed high dynamic range robotics computer vision applications addition global shutter intensity images asynchronous events provide inertial measurements ground truth camera poses motion capture system latter allows comparing pose accuracy ego motion estimation algorithms quantitatively data released standard text files binary files rosbag paper provides overview available data describes simulator release open source create synthetic event camera data
women stress related behavioral profile linked cardiovascular disease men example women double rates stress related mental disorders depression posttraumatic stress disorder ptsd men higher rates exposure adversity early life profile may increase women long term risk cardiometabolic conditions linked stress especially coronary heart disease chd addition higher prevalence psychosocial stressors women may vulnerable adverse effects stressors chd perhaps altered neurobiological physiology emerging data suggest young women disproportionally susceptible adverse effects stress risk cardiovascular disease terms initiating disease well worsening prognosis women already exhibited symptoms disease women potential vulnerability psychosocial stress could also help explain higher propensity toward abnormal coronary vasomotion microvascular disease compared men elsevier ltd rights reserved
order provide recommendations regarding implementation computed tomography screening europe ests established working group eight experts field background current situation regarding screening europe available evidence ten recommendations prepared cover essential aspects taken account considering implementation screening europe issues implementation screening europe participation thoracic surgeons screening programs iii training clinical profile surgeons participating screening programs use minimally invasive thoracic surgery relevant surgical issues associated elements screening programs smoking cessation programs radiological interpretation nodule evaluation algorithms pathology reports thoracic surgeons play key role process therefore ests committed providing guidance facilitating process benefit patients surgeons
paper presents detailed cost analysis small scale concentrated solar power csp generator based parabolic dish collectors micro gas turbines mgt whose technical feasibility already demonstrated previous publications consortium system used either electric power combined heat power generation whether operating solar energy fossil fuel backup accounting manufacturing transportation erection costs manufacturing cost functions sensitive system size production volume single shaft recuperated engine different technological levels low high performance specifications considered results show specific cost base case low performance system units year slightly lower epsilon reduced annual production rate multiplied ten multiplied thousand cost lower dish stirling systems higher photovoltaic panels even high production voltimes furthermore utilisation high performance specifications reduces cost system kwe thanks substantial reduction size dish cost level system potential become competitive photovoltaics favourable environmental political market conditions elsevier ltd rights reserved
new era interaction persons physical spaces users want spaces smartly adapt preferences transparent way paper describes process planning reasoning modeling smart environment domestic industrial application taking advantage emerging wearable devices market smart watches fitness trackers etc newer wireless communication technologies nfc ble direct enabling noninvasive way user optimize efficiency comfort safety environments approach applied home automation public spaces also incorporated industrial level help build smart autonomous factories
computer numerical control cnc technology key technology machine tools also base industrial unit computerization cnc machines operated controllers software module inside known interpreter function interpreter extract data computer aided manufacturing cam system generated code convert controller motion commands however development numerical control technology existing cnc systems limited interpreter lacking expandibility modularity openness order overcome problems open architecture technology oac employed cnc controller paper new technique presented interpretation international standards organization iso data interface model proposed technique able interpret iso data translate internal structure required cnc machine takes input file text format extracts position feed rate tool spindle data also able generate output text extensible markup language xml files per user defined file structure use txt xml files enables shop floor data modification internet accessibility facilities cnc system paper includes introduction brief description architecture algorithm design operational pattern validation system experimental studies output experiments illustrated satisfactory performance interpreter oac cnc system
accelerating integration joint replacement healing bone fracture particularly complicated non union fracture would improve patient welfare decrease healthcare costs currently autologous bone graft gold standard method treatment complicated non union fractures always possible harvest graft proactive highly inductive called smart material approach pertinent cases study surface chemistry previously approved material desirable bulk material properties modified investigate potential economical effective alternative objective create stable synthetic chemical coatings could guide cells along osteogenic lineage required generate mineralised tissue would induce accelerate bone healing primary human osteoblast like cells cultured vitro days amine terminated chain length range silane modified glass surfaces controlled nanotopography determine surface chemistry nanotopography change osteoblast function materials characterised using atomic force microscopy afm scanning electron microscopy sem water contact angle wca novel ninhydrin assay cells analysed using qrt pcr von kossa tinctural staining mineralisation visualised using transmitted white light electron microscopy bone like nodules quantified using microscopy formed short chain chain length amines days regulation sclerostin suggestive mature osteoblast phenotype paper report rapid nodule formation previously observed without addition exogenous factors culture medium suggests coating would improve integration implants bone basis smart biomaterial would accelerate bone regeneration process
model driven engineering uses models various stages software engineering reduce cost modelling production models reused transforming therefore accuracy model transformations plays key role ensuring quality process however problems exist trying transform abstract content dependent model paper describes issues arising transformations solutions solve problems content based model transformation proposed well usage proposed solutions allowing realization semi automatic transformations integrated tool designed opc xml drawing file transformations cysemol models accuracy transformations tool analyzed presented paper acquire data proposed solutions influence accuracy content based model transformation
decades medicine placebo effect conceptualized subjective psychological effect associated inert substance considered nuisance noise assessment therapeutic effects clinical trials however research placebo undergone substantial developments since mid several fields knowledge including methodology psychology neurosciences challenge traditional view using meta narrative approach review conceptualizations determinants mechanisms models placebo effects shows placebo effects genuine biopsychosocial phenomena strongly affected context factors surrounding patient treatments psychological experiments neurobiological neuroimaging studies identified various types placebo responses driven different mechanisms especially expectation conditioning associated different chemical structural functional features insights mechanisms involved placebo responses led opportunities ethical enhancements mechanisms clinical practice notably improving patient doctor interaction refining therapeutic ritual developments carefully considered rheumatology settings placebo effects prevalent significant potential improve patient care
paper gives comprehensive discussion applying cloud computing technology new information infrastructure next generation power system first paper analyzes main requirements future power grid information infrastructure limitations current information infrastructure based layered cloud based information infrastructure model next generation power grid proposed thus paper discussed different categories power applications benefit cloud based information infrastructure demonstration purpose paper develops three specific cloud enabled power applications first two applications demonstrate develop practical compute intensive data intensive power applications utilizing different layered services provided state art public cloud computing platforms third application propose cloud based collaborative direct load control framework smart grid show merits cloud based information infrastructure cybersecurity considerations challenges limitations cloud based information infrastructure also discussed
paper introduces high power density step converter led applications based hybrid serial output hso architecture suitable chip implementation system output voltage formed stacking output switched capacitor converter top boost converter output high power density converter processes around half power system left unregulated boost converter processes remainder power regulates output voltage comparison conventional boost based solutions introduced boost hso drastically reduces passive component volume decreases peak voltage stress switches experimental results obtained khz prototype show introduced boost hso converter three times smaller reactive component area conventional boost power processing efficiency
previously many morbidly obese patients denied liver transplantation higher operative risk however nowadays years graft survival rule patients whose lives prolonged dying obesity related comorbidities recent experience suggests weight reduction liver transplant recipients would improve long term survival bariatric surgery contraindicated patients decompensated cirrhosis post transplant intervention associated increased technical difficulty present experience three patients underwent simultaneous liver transplantation sleeve gastrectomy median months follow patients alive normal allograft function significant weight loss combined liver transplantation simultaneous sleeve gastrectomy appears technically feasible relatively safe selected patients
aimthe aim study report long term patient outcomes retropubic transobturator mid urethral slings female stress urinary incontinence methodswomen underwent mid urethral sling stress urinary incontinence invited participate survey regarding overall improvement patients outcomes assessed using international consultation incontinence questionnaire short form global response assessment scale resultsthe questionnaires completed patients median age time surgery years median follow period years retropubic transobturator approaches performed patients respectively international consultation incontinence questionnaire short form score dropped average significant difference two groups global response assessment scale showed greater improvement retropubic transobturator approach novo overactive bladder commonest long term reported adverse event affecting patients voiding dysfunction required surgical correction following retropubic approach occurred three patients conclusionmid urethral slings management female stress urinary incontinence good durable long term effects although retropubic approach gave better results significantly different transobturator approach
disease activity multiple sclerosis classically defined occurrence new neurological symptoms rate relapses definition disease activity become refined use clinical markers evaluating ambulation dexterity cognition magnetic resonance imaging mri become important tool investigation disease activity number lesions well brain atrophy used surrogate outcome markers several clinical trials reduction measures appreciated treatment studies increasing availability new medications overall goal minimize inflammation decrease relapse rate ultimately prevent long term disability aim review give overview commonly used clinical imaging markers monitor disease activity emphasis use clinical studies give recommendation utilize measures clinical practice appropriate assessment therapeutic response
polypropylene bis tetradecylimidiazolium butane bromide blends prepared via melting blending structure properties blend characterised tested results testing indicate could heterogeneous nucleating effect matrix moreover readily form alpha crystal crystallizing process help xrd data show crystallizing process could affected thus decreased crystallinity dsc results show melting point crystallization temperature blends close neat maybe due good compatibility long alkyl chains addition presence could improve antistatic properties apparently surface resistivity decreased omega content blends phr mechanical properties tensile strength decreased impact strength materials presented opposite results incorporated dma results show glass transition also decreases phr exists matrix therefore plasticized effect matrix experiments
jet electrochemical machining promising shaping method potential replace traditional sinking ecm industry owing flexibility stability however machining quality impaired occurrence unique phenomenon anode uniformly dissolved high nozzle travel rate paper aims analyze unique phenomenon viewpoint anodic behavior select optimum travel rate parameter window anodic behavior titanium alloy sodium chloride solution investigated linear sweep voltammetry cyclic voltammetry electrochemical impedance spectroscopy chronoamperometry time dependent mechanism pitting large localized corrosion polishing anodic interface structure developed full electricity quantity equivalent oxide layer capacitor proposed criterion initiation uniform dissolution state subsequently novel model incorporates parameter developed account effect anodic behavior model able predict machined profile well localized corrosion range finally effect nozzle travel rate jet ecm performance investigated nozzle travel rate selected optimum parameter window present work elsevier ltd rights reserved
background fitting statistical models complex health outcome data zero inflation autocorrelation confounding seasonality play important role accurately assessing air pollution risk especially using model estimates national air quality health indices naqhi formation naqhi generalizes model estimates across geographies seasons neglects area season specific variations aim develop complex statistical models specific data structures demonstrate effectiveness model estimates public health message delivery using naqhi methods fitted zero inflated auto regressive poisson negative binomial models lagged effects sparse asthma admissions ambient air pollution data compared model risk estimates naqhi data came two sites halifax urban traffic industry polluted site sydney rural waste disposal polluted site province nova scotia canada data complexity structure assessed comparing estimates without structure results naqhi used three pollutants nitrogen dioxide ozone particulate matter found carbon monoxide urban site lead waste disposal site prominent pollutants significant seasonal differences findings demonstrated severe assessment asthma admission relative risk naqhi auto correlation zero inflation ignored whereby prominent pollutant effects omitted conclusion study demonstrated importance complex statistical model use consequences consideration specific data structures public health risk assessments
although major risk factor alzheimer disease aging parameter systematically considered preclinical validation anti drugs explore aging affects neuronal reactivity anti agents ciliary neurotrophic factor cntf eassociated pathway chosen model comparison neuroprotective properties cntf month old mice revealed cntf resistance older animals associated exclusion cntf receptor subunits rafts subsequent dispersion non raft cortical membrane domains age dependent membrane remodeling prevented formation active cntf receptor complexes activation prosurvival stat erk pathways demonstrating age altered membranes impaired reactivity potential therapeutic targets cntf receptor distribution cntf signaling responses improved older mice receiving dietary docosahexaenoic acid cntf receptor functionality similar younger mice pointing toward dietary intervention promising adjuvant strategy maintain functional neuronal membranes thus allowing associated receptors respond appropriately anti agents elsevier inc rights reserved
objective study designed evaluate effects equol resveratrol supplementation health related quality life hrqol otherwise healthy menopausal women hot flashes anxiety depressive symptoms methods sixty recently menopausal women aged years randomized week placebo controlled trial receive fermented soy containing equol resveratrol tablet day primary outcome change score menopause rating scale mrs used evaluate severity age menopause related complaints additional outcome measures included subject reported score hamilton rating scale depression ham nottingham health profile nhp used specifically assess sleep quality results symptoms assessed mrs improved treatment active group comparison placebo treatment groups revealed statistically significant improvement particular dryness vagina heart discomfort sexual problems ham significant improvements week seen work activities subjects treated equol resveratrol also significant differences sleep domain nhp conclusion findings provide evidence weeks dietary supplementation equol resveratrol may improve menopause related quality life healthy women elsevier ireland ltd rights reserved
mining important persons significant network security especially researches email network centralization nowadays solve problem traditional pagerank algorithm sensitive network disturbance paper proposes method decomposes email network different layers based core number eliminates interferential nodes outer layers besides improves pagerank algorithm ranks nodes quantitatively find important nodes experiments indicate improves accuracy reduces computational complexity mining important nodes email network
alkaline pectate lyases pels potential application bioscouring textile industry study thermo alkaline pel bacpela gene alkaliphilic bacillus clausii strain cloned overexpressed escherichia coli mature bacpela exhibited maximum activity degrees showed high cleavage capability methylated pectins bacpela showed highest specific activity methylated pectin standard substrate polygalacturonic acid pga upon evaluation absorbance cat values pga respectively moreover dinitrosalicylic acid dns assay detects released reducing oligogalacturonic acids confirmed inaccurate unsuitable endo acting pectinase activity assay difference reducibility dns reagent standard galacturonic acid catalytic oligomer products significant ramie fiber weight loss observed following treatment bacpela combined enzyme chemical method indicated degumming efficiency bacpela highest alkaline thermostable pels reported date total activity recombinant mature bacpela reached high cell density cultivation fed batch fermentation productivity using coli host represents highest pel yield reported date therefore bacpela promising properties bioscouring shows potential applications ramie degumming textile industry
analyzing situation water resources south central hebei water crisis assessment indicator system established indicators chose three aspects water resources status water use rationality socioeconomic development corresponding set assessment criteria set indicators every administrative region south central hebei calculated assessed conclusion demonstrated water resource condition south central hebei poor widely high water shortage grade great potential water resource tapping saving area reclaimed water reuse rainwater utilization good measure tap water resource area water saving irrigation water conservation daily life good measures save water resource south central hebei finally countermeasures put forward water diversion project water project water prices rising water conservation service system construction water conservation propaganda
background unclear whether patients physicians understand atrial fibrillation ablation afa shown improve symptomology reduce morbidity mortality methods note consecutive patients referred electrophysiology clinic atrial fibrillation management responded anonymously survey via mail note physicians responded survey via email comparisons among groups conducted using chi test categorical variables odds ratios confidence intervals estimated using multivariate logistic regression model results almost half patients physicians believed ablation afa would eliminate need anticoagulation majority groups believed afa would improve survival great majority groups believed afa would decrease stroke rates comparing noncardiologists cardiologists noncardiologists likely believe afa would eliminate need anticoagulation improve survival decrease stroke respectively conclusions perceived benefit afa patients physicians supported medical literature responsibility electrophysiology community educate patients referring physicians regarding true benefits afa addition study displays great need long term clinical trials examining impact afa morbidity mortality
statistics series ordinary least squares problems ols used study linear correlation among sets variables interest many studies number variables least millions corresponding datasets occupy terabytes disk space availability large scale datasets increases regularly challenge dealing indeed traditional solvers rely use black box routines optimized one single ols highly inefficient fail provide viable solution big data analyses case study paper consider linear regression consisting two dimensional grids related ols problems arise context genome wide association analyses give careful walkthrough development ols grid high performance routine shared memory architectures analogous steps relevant tailoring ols solvers applications particular first illustrate design efficient algorithms exploit structure ols problems eliminate redundant computations show effectively deal datasets fit main memory finally discuss cast computation terms efficient kernels achieve scalability importantly design decision along way justified simple performance models ols grid enables solution correlated ols problems operating terabytes data matter hours elsevier inc rights reserved
paper presents standalone root chopper amp operates supply frequency compensation achieved power area efficient manner using current attenuator dummy differential output result overall amp consumes supply current die area modulated chopper ripple suppressed local feedback technique called auto correction feedback acfb charge injection input chopping switches cause residual offset voltages especially wider switches needed reduce thermal noise employing adaptive clock boosting technique nmos input switches amount charge injection minimized kept constant input common mode voltage changes results maximum offset degrees maximum drift amplifier entire rail rail input common mode range degrees degrees design implemented cmos process augmented cmos transistors
multiple binomial sums form large class multi indexed sequences closed partial summation contains sequences obtained multiple summation products binomial coefficients also sequences algebraic generating function study representation generating functions binomial sums integrals rational functions outcome twofold firstly show univariate sequence multiple binomial sum generating function diagonal rational function secondly propose algorithms decide equality multiple binomial sums compute recurrence relations conjunction geometric simplifications integral representations approach behaves well practice process avoids computation certificates problem appearance spurious singularities afflicts discrete creative telescoping theory practice elsevier ltd rights reserved
non latina black breast cancer patients experience shorter survival breast cancer non latina white counterparts compared breast cancer specific survival subset black white patients estrogen progesterone receptor positive tumors generally targeted endocrine therapy using data collected population based cohort breast cancer patients chicago kaplan meier survival curves hazard functions generated proportional hazards models estimated determine black white disparity time death breast cancer adjusting age diagnosis patient characteristics treatment related variables tumor grade stage regression models hazard breast cancer death among positive patients least times higher black white patients models tested notably even adjusting stage diagnosis tumor grade treatment variables including initiation systemic adjuvant therapies hazard ratio death positive breast cancer black white women observed racial disparity breast cancer survival patients diagnosed positive tumors appear due differences tumor stage grade therapy initiation black patients suggesting may racial differences molecular characteristics hormone receptor positive tumors positive tumors black patients may less responsive standard treatments
backgrounda small body research suggests gene environment interactions play important role development bipolar disorder aim present study contribute work exploring relationship stressful life events catechol methyl transferase comt val met polymorphism bipolar disorder methodsfour hundred eighty two bipolar cases psychiatrically healthy controls completed list threatening experiences questionnaire bipolar cases reported events experienced months worst depressive manic episodes controls reported events experienced months prior interview genotypic information comt val met variant extracted gwas analysis sample resultsthe impact stressful life events moderated comt genotype worst depressive episode using val dominant model adjusted risk difference confidence intervals worst manic episodes significant interactions comt stressful life events detected conclusionsthis first study explore relationship stressful life events comt val met polymorphism focusing solely bipolar disorder results study highlight importance interplay genetic environmental factors bipolar depression
entrepreneurial orientation widely acknowledged strong predictor firm performance therefore critical understand factors conditions nurture paper investigate configurations motivations personality traits trigger entrepreneurial orientation three strategic leadership situations successor family business family oriented founder non family founder strategic leaders situations differently exposed opportunities constraints pursue entrepreneurial posture influence family embeddedness organizational resistance apply fuzzy set qualitative comparative analysis sample italian sme owner managers identify coherent configurations internal external motivations personality traits conducive entrepreneurial orientation configurations consistent features family organization environments entrepreneurial action takes place furthermore strategic leadership situation different configurations attributes lead entrepreneurial orientation elsevier ltd rights reserved
background readmissions constitute major health care burden among critical limb ischemia cli patients objectives study aimed determine incidence readmission factors affecting readmission cli patients methods adult hospitalizations diagnosis code cli included state inpatient databases florida new york california data merged directory available american hospital association obtain detailed information hospital related characteristics geographic routing analysis performed evaluate effect travel time hospital readmission rate results overall admissions patients analyzed admissions principal diagnosis cli primary cli admissions cause readmission rates days months respectively majority unplanned readmissions unplanned readmission rates days months respectively major predictors month unplanned readmissions included age female sex black hispanic race prior amputation charlson comorbidity index need home health care rehabilitation facility upon discharge patients covered private insurance least likely readmission compared medicaid insurance medicare populations travel time hospital inversely associated month unplanned readmission rates significant interaction travel time major amputation well travel time revascularization strategy however inverse association travel time unplanned readmission rate evident subgroups furthermore length stay index hospitalization directly associated likelihood month unplanned readmission odds ratio log transformed length stay confidence interval conclusions readmission among patients cli high majority unplanned readmissions several demographic clinical socioeconomic factors play important roles predicting readmissions coll cardiol american college cardiology foundation
paper presents approach designing file manager speech interfaces speech interfaces primarily use speech recognition synthesis interacting user input output present system used various graphical user interface gui operating systems file managers based see get model providing point click approach support hierarchical folder structure point click suitable gui becomes inefficient speech interfaces speech interfaces implemented currently systems like microsoft speech recognition navigate hierarchical file structure navigate sequentially various sub folders necessitates need display view folders files directory traversed approach user freed responsibility traversing folders provides method retrieve files based various file attributes relevance paper focus design architecture file manager paper also analysis results based usability survey system presents comparison existing file managers advantage using system designed specifically speech interfaces allows user use system minimal displays
introduction preterm birth remains significant public health issue children born prematurely experiencing health educational difficulties throughout childhood specific aim study evaluate educational implications actual potential health risks premature birth children middle childhood compared children age born term methods descriptive study secondary analysis national survey children health specifically year old subset comparing children identified born premature born term educational health outcome variables explored results preterm birth negatively affects educational experience children born prematurely logistic modeling provides insight predicting risk discussion collaboration primary care providers educators families recommended improve care coordination address educational need children born premature
rainwater harvesting rwh method capturing rainfall catchment surface storing later use though around thousands years popularity use increasing recent years water quality within rwh systems become concern water temperature parameter affects water quality storage container color shading affect temperature rainwater storage containers four different colors kept three different shadings used study effects shading container color water temperature temperatures water stored containers monitored weeks texas summer statistical analyses showed color shade variables interaction thus together effect water temperature individual treatment variables could analyzed compared statistically however trends showed light colors higher shading caused lower water temperatures storage containers also color pronounced effect shading water temperature inside containers
communication may verbal nonverbal communication changes commonly reported older people typical process aging communication skills change due health issues depression cognitive problems review manuscript communication problems elderly people presented health problems found individuals older age groups may affect communication examples follows cerebral palsy multiple sclerosis hearing visual loss aphasia neurodegenerative diseases improve communication older adults measures followed speak normal conversational pace avoid speaking quickly slowly repeat elaborate important points communication disorders experienced older adults etiologic factors may related general health problems neurological problems hearing visual loss social problems retirement social isolation older adults communication disorders everyone throughout society especially health care specialists aware problem use simple measures improve communication problems paper issue communication problems elderly people evaluated
rural south african men sex men msm likely underserved terms access relevant healthcare hiv prevention services research urban peri urban msm populations identified range factors affecting hiv risk south african msm little research available examines hiv risk prevention rural msm populations exploratory study begins address lack assessing perceptions hiv risk among msm rural limpopo province using thematic analysis interview discussion data two overarching global themes encapsulated participants understandings hiv risk hiv risk environment communities developed first theme community experience rural social environment factors affecting hiv risk within broad risk environment discussed included perceptions traditional value systems communities homophobic jealousy competition msm role social media means meeting msm second global theme hiv aids knowledge risk experience focused factors immediately affecting hiv transmission risk included high levels knowledge heterosexual hiv risk limited knowledge msm specific risk inconsistent condom lubricant use difficulties negotiating condom lubricant use due uneven power dynamics relationships competition sexual partners multiple concurrent sexual partnerships transactional sex exploratory results suggest rural south african msm like urban peri urban counterparts high risk contracting hiv need depth research interactions rural context specific hiv risk knowledge behaviours affect hiv risk population
aim present study investigate prevalence ponticulus posticus among patients dental angle class iii malocclusions middle anatolian population total cephalometric radiographs examined months period patient assigned identification number demographic information absence presence present type type dental malocclusion recorded two observers cases disagreement third observer consulted distributions obtained values analysed using pearson chi square test mean age subjects years range analysed sample prevalence complete form incomplete form significant difference genders prevalent male patients significant difference found age groups frequently detected angle class iii patients significant difference malocclusion groups present study found relatively common anomaly patients dental malocclusions although angle class iii patients showed higher frequency statistically significant difference found among dental malocclusion groups
neoadjuvant chemotherapy administration chemotherapy surgery commonly used locally advanced breast cancer improve surgical outcomes increase opportunity breast conserving therapy women breast cancer often receive anthracycline based regimen neoadjuvant chemotherapy associated high risk emesis despite development novel antiemetics chemotherapy induced nausea vomiting cinv commonly reported major adverse effect affecting quality life patients however factors predicting cinv women breast cancer undergoing neoadjuvant chemotherapy remain unclear single institution prospective observational study conducted outpatient cancer centre republic korea november march analysed women breast cancer planned treated neoadjuvant chemotherapy surgery candidate factors associated cinv assessed neoadjuvant chemotherapy using munich chronotype questionnaire pittsburgh sleep quality index hospital anxiety depression scale cinv assessed chemotherapy using multinational association supportive care cancer antiemesis tool total participants patients lost follow patients excluded due changes treatment plan thus patients finally included analyses overall participants experienced cinv delayed cinv prevalence common acute univariate analyses overall cinv significantly associated late chronotypes odds ratio confidence interval history nausea vomiting anxiety multivariate analyses late chronotypes history nausea vomiting remained significantly associated cinv conclusion women breast cancer undergoing neoadjuvant chemotherapy surgery late chronotypes found increased risk cinv data suggest clinicians need assess consider chronotype management cinv
paper presents results experimental study performance pollutant emissions direct injection spark ignition engine devised joint operation high pressure thermochemical recuperation system based methanol steam reforming comparison gasoline ethanol decomposition performed engine feeding methanol steam reforming products shows increase indicated efficiency reduction nox emissions respectively compared gasoline within wide power range efficiency improvement emissions reductions obtained compared ethanol decomposition products well possibility unthrottled engine operating substantially lower cycle cycle variation compared gasoline ethanol decomposition demonstrated high loads injector flow area insufficient low injection pressure bar leading late injection reduced engine efficiency methanol steam reforming products case ethanol decomposition problem less severe due higher energy content ethanol decomposition products per mole concept direct injection internal combustion engine high pressure methanol steam reforming shows good potential additional research injection strategies gaseous reformate combustion required elsevier ltd rights reserved
characterizing humans ability discriminate changes illumination provides information visual system representation distal stimulus previously shown humans able discriminate illumination changes sensitivity changes depends chromatic direction probing illumination discrimination would facilitated use computer graphics simulations would practice enable wider range stimulus manipulations priori guarantee however results obtained simulated scenes generalize real illuminated scenes investigate question measured illumination discrimination real simulated scenes well matched mean chromaticity scene geometry illumination discrimination thresholds essentially identical two stimulus types previous work thresholds varied illumination change direction exploited flexibility offered use graphics simulations investigate whether differences across direction preserved surfaces scene varied show varying scene surface ensemble manner also changes mean scene chromaticity modulates relative sensitivity illumination changes along different chromatic directions thus characterization sensitivity changes illumination must defined relative set surfaces scene
objective study examine factors facilitating constraining identification management intimate partner violence ipv emergency department semi structured interviews conducted employees university hospital netherlands interviews audiotaped transcribed verbatim analyzed using qualitative content analysis atlas constraining factors lack knowledge awareness resources employees felt many barriers bringing ipv facilitating factors good cooperation among staff involvement one team member producing ipv protocol received training child abuse private consulting rooms setting employees task perception attitude contained constraining facilitating factors employees saw task responsibility help ipv victims priorities secure high turnover treat acute physical problems although employees expressed openness willingness help also took view victims considerable responsibility disclosing managing ipv led ambivalent feelings conclusion employees faced tensions ipv identification management caused lack awareness knowledge resources conflicting priorities ambivalent feelings improvements made supporting employees guidelines form protocol training also addresses tensions employees face
reliability raid system utilize reconstruction operations recover data disk fails however result longer recovery time negative impact system performances moreover possibility secondary failure increased recovery period paper proposed new reliability optimization method raid system active data migration called ram allocates reserved space every disk arranges redirect data non repairable sectors reserved space called internal disk data migration number bad sectors disk exceeds threshold disk poor reliability system copy data unreliable disk new one called external disk data migration process avoid lengthy data reconstruction dynamically adjust migration speed reduce impact front end performance load system bursting requests user high priority overall results indicate ram improve reliability system little influence elsevier inc rights reserved
paper deals oscillating generators driven free piston engines original free swinging piston engine oscillating rotary generator distinguishes compactness minimum frictional losses full balanced mechanical system possibility four stroke operation internal combustion engine possibility multi fuel operation engine including possible version stirling engine optimal magnetic circuit electrical generator etc engine optimally operate whole range output power enables improve electrical system hybrid vehicle usage supercapacitors instead battery way competitive hybrid electric vehicle electrical vehicle effective range extender created
mobile robot localization allows robot identify position one main challenges field robotics work provide evaluation consolidated feature extractions machine learning techniques omnidirectional images focusing topological map localization tasks main contributions work novel method localization via classification reject option using omnidirectional images well two novel omnidirectional image data sets localization system analyzed virtual real environments based experiments performed minimal learning machine nearest neighbors classifier local binary patterns feature extraction proved best combination mobile robot localization accuracy fscore elsevier ltd rights reserved
three experiments show describing person mixed rather consistently positive negative terms warmth competence two fundamental dimensions social perception results extreme impressions given sparse information one dimension amplified extreme judgments arise dimension clearly opposite valence experiment competent cold target perceived competent competent warm target experiment extends amplification effect manipulating either warmth competence adding consistently negative descriptions experiment replicates amplification using naturalistic behavioral descriptions findings extend compensation effect negative functional relation perceived warmth competence previously observed explicitly comparative contexts single target impression formation implications traditional person perception models distributed social cognition discussed elsevier inc rights reserved
solve problem throughput decrease caused spectrum interference wireless local area networks wlan paper proposes network model based wireless sensor network wsn cooperative spectrum sensing model takes advantage wsn features distributed computing system synthesis determine channel combination less spectrum interference hence improves system throughput furthermore key technologies designed practical applications including nodes communication procedure access point wlan sensor nodes wsn algorithms selecting channels less spectrum interference strategy adapting network best channel combination test results verification platform based typical high density indoor coverage scenario show sensing ability proposed network model better single sensing compared traditional wlan without sensing ability wlan based sensing throughput proposed network model raised
sleep disturbance common parkinson disease negatively impacts quality life little data dopamine agonists influence nocturnal sleep particularly sleep laboratory data measure sleep parameters changes objectively goal open label study objectively evaluate effect rotigotine sleep patients video polysomnographic methods total patients complaints nocturnal sleep impairment enrolled sleep quality stable rotigotine therapy evaluated subjectively questionnaire assessments objectively measured video polysomnographic methods parkinsonism depression anxiety quality life patients also evaluated questionnaire assessments end rotigotine treatment daytime functioning motor performance depression subjective quality sleep quality life improved video polysomnographic analysis showed sleep efficiency stage increased sleep latency wake sleep onset periodic leg movements sleep index decreased rotigotine treatment video polysomnographic analysis confirmed subjective improvement sleep rotigotine treatment observation suggests rotigotine treatment option patients complaining sleep disturbances
current practice many digital models contain sufficient information designers contractors operators great deal literature pointed importance understanding building information modeling bim bim digital representation physical functional characteristics building architecture engineering construction bim development use computer software model stimulate construction operation facility make decisions improve process delivering facility aims paper explore need technological support implement site linked bim benefits bim challenges bim research conducted literature review bim data collected questionnaire survey carried valid responses within main stakeholders construction work surabaya questionnaire prepared incorporating technological support benefits challenges bim data analyzed using descriptive analysis including mean analysis likert scale results research shows need technological support implement bim parametric components mean value need software package majority prepared contractor construction management consultant benefit bim reduce construction cost mean value addition main challenge bim different brand mean value incompatibility different brand mean value authors published elsevier ltd
big data consists huge volume complex growing data sets several independent sources rapid development data collection storage capacity big data expanding science engineering domains fundamental challenge big data applications scrutinize large amount data extract required information knowledge future usage beyond limit relational databases respect storage processing massive quantity data intent paper considering big data repository twitter dynamically mine recent tweets related kapoor sons movie perform data mining operation analytics overcoming challenges categorized respect hace theorem handle massive amount tweets used hadoop map reduce framework perform data mining analytic operations data cleansing data classification data clustering prediction model movie review built using naive bayes classifier accuracy prediction calculated help binomial test conforms bernoulli distribution clustering tweets obtained basis location hash tags additionally privacy user tweets preserved using data mining anomaly technique results displayed help intelligent graphs performance evaluation map reduce predictive analysis done using map reduce well without using map reduce based execution time comparison performance graph obtained prove map reduce efficient framework huge volume data
background phenotypic data routinely used elucidate gene function organisms amenable genetic manipulation however previous work generalizable system place structured storage retrieval phenotypic information bacteria results ontology microbial phenotypes omp created standardize capture phenotypic information microbes omp built foundations basic formal ontology phenotype trait ontology terms logical definitions facilitate computational searching phenotypes associated genes omp accessed via wiki page well downloaded sourceforge initial annotations omp made escherichia coli using wiki based annotation capture system new omp terms concurrently developed annotation proceeds conclusions anticipate diverse groups studying microbial genetics associated phenotypes employ omp standardizing microbial phenotype annotation much gene ontology standardized gene product annotation resulting omp resource associated annotations facilitate prediction phenotypes unknown genes result new experimental characterization phenotypes functions
project series electric drivetrain sized small agricultural machinery developed tested electric drives noted benefits simplicity controllability integration electronics provide autonomous action efficiency wide operating range biggest drawback agricultural use limited capacity electrical energy storage series hybrid drivetrain provides method overcome capacity constraints use chemical energy storage series hybrid drivetrain research designed using well established components consisted diesel electric generator lead acid battery pack motor controller independent electric motors wheel associated gearboxes produce speeds torques suitable ground drive although components commercially available integrated hybrid drivetrain goal project test drivetrain determine baseline performance investigate efficiencies various drivetrain components operating different conditions drivetrain efficiency tested using factorial test factors average load level full load load profile type variable constant size battery pack efficiencies three main components drivetrain monitored testing diesel electric generator battery system ground drive tested factors load level effect efficiency overall efficiency efficiency battery system system components appreciably impacted factors large battery packs necessary maintain efficiency even variable loads indicates future machines could consider advanced expensive types batteries less capacity would required agricultural engineers interested using electric motor drives various benefits use series hybrid design overcome energy storage limitations realize consistent efficiencies variety operating conditions
bunch charge variations free electron lasers free electron laser hamburg flash european ray free electron laser xfel impacts longitudinal phase space distribution electrons resulting different bunch peak currents pulse duration pulse shapes electron bunches generated short ultraviolet laser pulses impinging onto photocathode inside radio frequency accelerating cavity flash bursts bunches pulses intra train repetition rate mhz used even higher repetition rates xfel mhz planned charge variations along bunch trains caused variations laser pulse energies instabilities accelerating fields cavity time dependent effects photoemission process improve intra bunch train charge flatness compensate train train fluctuations dedicated digital control system based micro telecommunication computing architecture microtca standard designed implemented successfully tested flash system consists bunch charge detection module analyzes data toroid system provides input signal controller drives fast pockels cell installed optical path photo cathode laser pockels cell alters laser polarization thus transmission polarizer modulation laser pulse energy iterative learning feed forward minimizing repetitive errors bunch train bunch train fast feedback algorithm implemented field programmable gate array fpga allows fast tuning bunch charge inside bunch train paper detailed description system first measurement results presented
background lack data marginalized populations knowledge attitudes practices kap hampers efforts improve modern contraceptive practice mixed methods study better understand family planning kap amongst refugee migrant women thailand myanmar border conducted part ongoing effort improve reproductive health particularly maternal mortality shoklo malaria research unit smru antenatal birthing services methods cross sectional surveys focus group discussions fgds currently pregnant women depth interviews idis selected post partum women three children conducted quantitative data described medians proportions compared using standard statistical tests risk factors associated high parity identified using logistic regression analysis qualitative data coded grouped discussed using identified themes results january march women participated cross sectional studies fgd idi major positive findings women knew contraceptives birth spacing women fgd idi reported use family planning past nearly women knew could obtain supplies major gaps identified included low uptake long acting contraception lac lack awareness emergency contraception women unreliable estimates child bearing years end misconceptions surrounding female sterilization three identified ideal number children cross sectional survey less half women parity higher idi actually adopted lac leaving risk unintended pregnancy discussing basic female anatomy using simple diagram well received fgd idis lac uptake increased particularly iud conclusion definitive contextual issues identified study significant range action points implemented services smru result particularly regard iud importance role attitudes husbands acknowledged women studies investigate male perspectives future may enhance practice area
simplified method measuring fluidic resistance fluidic microfluidic channels presented electrical resistance elec channel filled conductivity standard solution measured directly correlated fluidic using simple equation although slight correction factor could applied system improve accuracy results showed standard voltage meter could used without calibration determine fluidic within error results accurate within obtained geometric correction factor applied using particular channels compared standard flow rate measurements meniscus tracking outlet tubing approach provided straightforward alternative resulted lower measurement error method validated using different fluidic resistance values similar kpa separately fabricated microfluidic devices furthermore since method analogous resistance measurements voltage meter electrical circuits dynamic fluidic measurements possible complex microfluidic designs microchannel elec shown dynamically mimic pressure waveforms applied membrane variable microfluidic resistor variable resistor used dynamically control aqueous oil droplet sizes spacing providing unique convenient control system droplet generating devices conductivity based method fluidic resistance measurement thus useful tool static real time characterization microfluidic systems elsevier rights reserved
conventional organic rankine cycles orcs using ambient air coolant fully utilize greater temperature differential available colder months however changing working fluid composition boiling temperature matches ambient temperature changes shown potential increase year round electricity generation previous research assumed cycle pressure ratio able vary without major loss isentropic efficiency turbine paper investigates small scale orc systems normally use positive displacement expanders fixed expansion ratios could also benefit new concept numerical model firstly established based comprehensive analysis conducted results showed applied systems positive displacement expanders improve year round electricity generation however improvement less systems using turbine expanders variable expansion ratios furthermore improvement relies heat recovery via recuperator expanders fixed expansion ratio relatively constant pressure ratio inlet outlet increase pressure ratio evaporator condenser tuning condensing temperature match colder ambient condition winter utilised expanders however recuperator place higher discharging temperature expander could increase heat recovery consequently reduce heat input evaporator increasing thermal efficiency specific power higher amount heat energy transferred recuperator higher efficiency improvement
objective interventions required redress disproportionate tobacco related health burden experienced persons mental illness study aimed assess efficacy universal smoking cessation intervention initiated within acute psychiatric inpatient setting continued post discharge reducing smoking prevalence increasing quitting behaviours method randomised controlled trial undertaken across four psychiatric inpatient facilities australia participants randomised receive either usual care intervention comprising brief motivational interview self help material hospital followed month pharmacological psychosocial intervention upon discharge primary outcomes assessed months post discharge day point prevalence month prolonged smoking abstinence number secondary smoking related outcomes also assessed subgroup analyses conducted based psychiatric diagnosis baseline readiness quit nicotine dependence results seven day point prevalence abstinence higher intervention participants controls months post discharge odds ratio months respectively odds ratio significant intervention effects found measures prolonged abstinence either months post discharge differential intervention effects primary outcomes detected subgroups months post discharge intervention group participants significantly likely smoke fewer cigarettes per day reduced cigarette consumption made least one quit attempt relative controls conclusions universal smoking cessation treatment initiated inpatient psychiatry continued post discharge efficacious increasing day point prevalence smoking cessation rates related quitting behaviours months post discharge sustained effects quitting behaviour months research required identify strategies achieving longer term smoking cessation
drive eat regulated two compensatory brain pathways termed homeostatic hedonic hypothalamic orexinergic orx neurons regulate metabolism feeding reward thus controlling physiological hedonic appetite circadian regulation feeding metabolism rhythmic activity orx cells driven brain suprachiasmatic clock circadian clock impacts orx signalling feeding reward rhythms however unknown used mice lacking nuclear receptor rev erb transcription repressor key component molecular clockwork study food reward behaviour rev erb mutant mice showed highly motivated behaviours obtain palatable food increase intake preference tasty diets expression orx protein hypothalamus palatable food intake inhibited animals treated orxr antagonist analyzing orx promoter found retinoic acid related orphan receptor response element binding sites rev erb furthermore rev erb dampened activation orx vitro vivo data provide evidence possible repressive role rev erb regulation orx signalling highlighting implication circadian clockwork modulating food reward behaviours important impact central regulation overeating
paper compares smart control models heating supply air among five different climate conditions discuss effectiveness machine learning tools terms control energy efficiency thermostat control typically used maintain room temperature desired level advanced computing technologies recently introduced complement conventional controls improve control efficiency heating systems however methods mostly utilized control fuel amount fan motor speed lacked capability promptly respond various outdoor temperature conditions climate zones requiring refined control strategies reduce environmental impacts paper proposes intelligent controls mass temperature simultaneously heating air supply fuzzy inference system fis artificial neural network ann algorithms utilized develop six control models models tested evaluate control energy efficiency winter season five climate zones climate zone houston dallas raleigh chicago detroit respectively results include energy consumption control errors control signals comparison baseline control confirms fact ann simultaneous controls mass temperature effective controllers control accuracy energy savings respectively effectiveness ann controller contribute maintaining room temperature accompanying reduction energy consumption directly related improve human comfort reduce environmental impacts various climate zones elsevier ltd rights reserved
structural identification parametric correlation structural response characteristics predicted mathematical model analogous characteristics derived experimental measurements paper describes exercise humber bridge adopted novel two stage approach first calibrate validate mathematical model model used predict effects wind temperature loads global static deformation would practically impossible observe first stage process ambient vibration survey used operational modal analysis estimate set modes classified vertical torsional lateral recent second stage finite element model fem developed appropriate level refinement provide corresponding set modal properties series manual adjustments modal parameters cable tension bearing stiffness resulted fem produced excellent correspondence vertical torsional modes along correspondence lower frequency lateral modes third stage traffic wind temperature data along deformation measurements sparse structural health monitoring system installed compared equivalent predictions partially validated fem match static response fem shm data proved good enough fem used predict measurable global deformed shape bridge due vehicle temperature effects fem limited capability reproduce static effects wind addition fem used show internal forces due heavy vehicle estimate worst case bearing movements extreme combinations wind traffic temperature loads paper shows case limitations two stage fem calibration validation process effective tool performance prognosis
primary prevention programs pediatric abusive head trauma paht exist early screening proposed negative effects mislabeling parents abusers important issue well documented aim study simulate possible impact programs primary prevention screening paht developed markov models simulate life histories paht intervention primary prevention program screening program programs hypothetical cohort newborns high income country screening program would addressed families children years old repeated consultations potential side effects parents mislabeled abusers supposed increase probability paht decrease participation screening time horizon years cycles days outcomes number deaths abused children avoided uncertainty specified probability distributions years median number deaths avoided primary prevention would vary confidence interval per newborns screening could prevent cause deaths per children born alive impact programs uncertain model confirmed potential benefits primary prevention documented uncertainty associated screening paht
stress management interventions integrated treatments people mental disorders nevertheless studies interventions conducted patients schizophrenia western countries limited studies used objective measurements stress developed group based four session stress management manage program people mental disorders consisting two major components psychoeducation relaxation practice single group pretest posttest quasi experimental study undertaken test initial effects determine effect sizes program convenience sample inpatients recruited mental health ward tertiary hospital singapore self report questionnaires physiological measures stress skin temperature salivary immunoglobulin siga used data collection data analyzed descriptive statistics repeated measures analysis variance participants singaporean female single employed diagnoses included schizophrenia depression bipolar disorder anxiety disorder mixed diagnoses received standard care provided hospital participants significant reductions objective stress measured skin temperature effect size siga effect size subjective stress effect size well improved psychological health effect size response intervention study provides preliminary evidence support positive effects manage program people mental disorders future studies test efficacy program using rigorous methods randomized controlled trial multicenter study
new findings central question study airway angiogenesis occurs asthma airway smooth muscle asm cells reported capable promoting airway angiogenesis potential mechanism asm cells harvested patients asthma capable promoting airway angiogenesis main finding importance endogenous stat mediated pro angiogenic ability asm cells directly activating vegf signalling findings contribute understanding airway angiogenesis pathology could represent possible therapeutic target asthma airway angiogenesis indicates specific vascular structure remodelling occurs asthma airway smooth muscle asm cells reported capable promoting airway angiogenesis however potential mechanism yet fully defined herein investigated role signal transducer activator transcription stat progress airway angiogenesis western blot analysis showed stat activation aberrantly upregulated asm tissues patients asthma asm cells exposed cytokines imitate airway conditions patients asthma compared control group inhibition stat activation silencing endogenous stat asm cells significantly reduced proliferation migration tube forming ability human lung microvascular endothelial cells induced conditioned medium asm cells increased proliferation migration human aortic vascular smooth muscle cells also repressed inhibition stat asm cells besides increased activity vegf signalling observed asm cells pcr western blotting assay whereas increased activity reduced stat silencing studies indicated stat regulated vegf activation directly interacting binding site region vegf gene increase stat induced pro angiogenic activity asm cells significantly decreased administration vegf neutralizing antibody conclusion provided evidence endogenous stat mediates pro angiogenic ability asm cells directly activating vegf signalling could represent possible therapeutic target asthma
frequency response approach taken model unsteady aerodynamics resulting plunging oscillations airfoil oscillations range covers high angles attack degrees reduced frequencies particular attention range flow nonlinearities lift enhancement observed experiments performed wind tunnel airfoil section reynolds number airfoil acceleration lift force data used determine frequency response functions measured unsteady lift quasi steady lift results show enhanced lift amplitude stall regime reduced frequency flow dynamics associated observation identified water tunnel experiments particular attention paid flow separation consequent formation convection leading edge vortex optimization based system identification approach performed represent unsteady lift fourth order dynamical system representation suitable sensitivity dynamics control analyses especially applications unsteady aerodynamics exploited purpose lift enhancement
individuals living schizophrenia times likely experience type diabetes mellitus diabetes medication adherence essential reduce morbidity mortality population conducted meta analysis diabetes medication adherence among people schizophrenia compared without schizophrenia systematic search strategy used identify articles reporting adherence diabetes medications among patients schizophrenia total unique studies reporting data people schizophrenia included random effects meta analysis showed people schizophrenia adhered medication days prescribed adhered days per year without schizophrenia adherence month diabetes medication significantly without schizophrenia factors positively associated diabetes medication adherence age number outpatient visits along multiple medication administration variables future prospective research examine diabetes monitoring medication prescription subsequent adherence fully representative samples novel interventions maximizing compliance diabetes medication vulnerable population also explored
accuracy assumed similarity associated first impressions personality large scale video perception study accuracy assumed similarity strongly negatively associated across traits consistent past research beer watson however across perceivers perceiver target dyads ability perceive others accurately independent tendency assume similarity others thus viewing others general specific others overly similar self imply viewing inaccurately sum accuracy assumed similarity inversely related examined across traits independent across perceivers dyads elsevier inc rights reserved
equivalently implementing generalized memristor using common components making nonlinear circuit reliable property conducive experimentally exhibit nonlinear phenomena memristive chaotic circuit show practical applications generating chaotic signals firstly based memristive diode bridge circuit new first order actively generalized memristor emulator constructed grounded restriction ease realize mathematical model emulator established fingerprints analyzed pinched hysteresis loops different sinusoidal voltage stimuli results verified experimental measurements indicate emulator uses one operational amplifier nine elementary electronic circuit elements active voltage controlled generalized memristor secondly parallelly connecting proposed emulator capacitor linearly coupling bridge oscillator memristor based chaotic circuit without inductance element constructed dynamical model inductorless memristive chaotic circuit established phase portraits chaotic attractor typical circuit parameters obtained numerically dissipativity equilibrium points stabilities derived indicate phase space inductorless memristive chaotic circuit exists dissipative area distributed two unstable nonzero saddle foci non dissipative area containing unstable origin saddle point furthermore utilizing bifurcation diagram lyapunov exponent spectra phase portraits dynamical behaviors inductorless memristive chaotic circuit investigated results show evolution parameter value coupling resistor complex nonlinear phenomena coexisting bifurcation modes coexisting attractors two different initial conditions state variables found inductorless memristive chaotic circuit finally prototype circuit circuit parameters numerical simulations developed seen prototype circuit simple circuit structure inexpensive easy practically fabricate common components results experimental measurements numerical simulations consistent verifying validity theoretical analyses
bipolar disorder bpd schizophrenia sch show similar neuropsychiatric behavioral disturbances including impaired social interaction communication seen autism spectrum disorder asd multiple overlapping genetic environmental influences implicated risk course illness geneanalytics software used pathway analysis genetic profiling characterize common susceptibility genes obtained published lists asd genes bpd genes sch genes rank scores derived number nature overlapping genes gene disease association tissue specificity gene functions subdivided categories diseases tissues functional pathways twenty three genes common three disorders mapped nine biological superpathways including circadian entrainment genes score amphetamine addiction five genes score sudden infant death syndrome six genes score brain tissues included medulla oblongata genes score thalamus genes score hypothalamus nine genes score six common genes bdnf drd chrna htra slca tph overlapping genes impacted dopamine serotonin homeostasis signal transduction pathways impacting mood behavior physical activity level converging effects pathways governing circadian rhythms support core etiological relationship neuropsychiatric illnesses sleep disruption hypoxia central brain stem dysfunction
core flux switching permanent magnet machine large air gap delta medium speed application rpm presented general aspects machine design arising large air gap length machine discussed using finite element analysis found design rules conventional even alternate fspm machines longer applied large air gap present particularly choice rotor poles investigated improve torque capability fspm machine detail within machine design necessary reduce number rotor poles also beneficial reduction losses increased rotor speeds moreover height permanent magnets stator also need enlarged due large air gap machines prevent direct short circuit permanent magnet flux air gap additionally influence rotor skewing torque variation briefly discussed
design approach determining optimal flow pattern landscape lake proposed based fluent simulation multiple objective optimization parallel computing paper formulates design multi objective optimization problem lake circulation effects operation cost two objectives solves optimization problem non dominated sorting genetic algorithm lake flow pattern modelled fluent parallelization aims multiple fluent instance runs different fluent internal parallel solver approach proposes lake flow pattern metrics weighted average water flow velocity water volume percentage low flow velocity variance flow velocity defines user defined functions boundary setting objective constraints calculation parallels execution multiple fluent instances runs significantly reduce optimization wall clock time proposed approach demonstrated case study meijiang lake tianjin china
paper deals development signal conditioning circuit microcontroller compatibility interfacing capacitive sensors suitable wide range applications circuit comprises capacitive active bridge along relaxation oscillator converting capacitance changes frequency directly design analysis experimental results circuit application thin film based humidity sensor capacitive transducer measurement dielectric constant edible oil reported experimental results confirm theoretical values predicted frequency output circuit used determine response characteristics trace moisture sensor dielectric constants edible oils finally output frequency calibrated terms trace moisture parts per million ppm using commercial dew point meter shaw accuracy moisture measurement using custom designed capacitive sensor full scale moisture range ppm compared dew point meter accuracy found nearly resolution ppm moisture circuit less complex easy integrate application specific integrated circuits standard cmos technology high sensitivity selectable easily reproduced cheapest possible components achieving fairly good performance terms accuracy dynamic range
present study conducted investigate comparative parasitic ability root knot nematode rkn meloidogyne graminicola putatively resistant suraksha susceptible pusa cultivars rice analyse relative expression level plant defence genes upon rkn infection cultivars qrt pcr analyses rkn infected roots corresponding shoots indicated phytohormone mediated host defences activated early infection susceptible resistant plants whereas apparently suppressed later stage infection susceptible plants expression defence genes shoot tissues resistant plants suggested successful induction systemic acquired resistance parallel lignin callose mediated plant basal defence activated suraksha information generated rkn induced expression defence genes different rice varieties exploited improve resistance cultivated species rice rkn infection
supporting large amounts spatial data significant characteristic modern databases however unlike mature relational databases oracle postgresql current burgeoning nosql databases well designed storing geospatial data becoming increasingly important various fields paper propose novel method provide tree index well corresponding spatial range query nearest neighbour query functions mongodb one prevalent nosql databases first depth analysis mongodb features devise efficient tabular document structure flattens tree index mongodb collections relevant mechanisms tree operations issued discuss detail integrate tree mongodb finally present experimental results show proposed method performs built spatial index mongodb research greatly facilitate big data management issues mongodb variety geospatial information applications
system identification generalized predictive control class multiple input multiple output models studied generalized predictive control problem unknown parameters first addressed finding control sequence control performance goal unknown parameters models estimated new stochastic gradient algorithm providing high estimation accuracy third generalized predictive control problem formulated quadratic programming problem linear inequality constraints finally constrained quadratic programming problem solved generalized projection neural network simple structure small number neurons previous projection neural networks complex structure require neurons numerical simulations provided reinforce theoretical results
purpose uptake active surveillance changes prostate cancer care may affect utilization complications following prostate needle biopsy characterized recent trends risk factors prostate needle biopsy complications using statewide payer cohort materials methods used sparcs new york statewide planning research cooperative system identify prostate needle biopsies performed via transrectal transperineal approach patients respectively characterized trends utilization complications using poisson regression cochrane armitage test applied logistic regression examine predictors complications within days prostate needle biopsy results ambulatory use prostate needle biopsy decreased time common indication prostate needle biopsy elevated prostate specific antigen patients followed active surveillance cancer abnormal digital rectal examination atypia prostate needle biopsy associated infection rate increased study period among repeat prostate needle biopsies complication rate comparable initial prostate needle biopsy preprocedural rectal swab done less prostate needle biopsies multivariable analysis patient race procedure year diabetes transrectal approach recent hospitalization significantly associated infection median total charge infectious complications iqr conclusions across new york state infectious complications prostate needle biopsy increased time higher complications using transrectal approach minimal utilization targeted antibiotic prophylaxis efforts focus evaluation implementation strategies reduce post prostate needle biopsy complications nationally
recent demographic changes forest owner structure suspected led increasing number owners specific objectives forests addition continuous fragmentation forest holdings increased threat passiveness related forest management decrease tendency towards passiveness new policy tools initiatives suggested finnish context idea investor based jointly owned forest introduced facilitating effective utilization forest resource however collective ownership faced prejudice scepticism among private forest owners order expand forest owners need see idea jointly owned forests socially legitimate thus adopting van leeuwen framework analyzing legitimation new social practices examine finnish forest owners legitimate participation jointly owned forests qualitative data study consist depth interviews private forest owners joined jointly owned forest study contributes recent discussion jointly owned forests show change type ownership results moral authoritative rational justifications decision simultaneously renewing identity forest owner accordingly suggest forest ownership driven rational prospects moral emotional nature ownership better taken account policy level structural designs discussing promotion new types forest ownership
method deal design automatic parting calibrator computer aided design cad plastic profile extrusion dies via feature recognitions presented integral design method design calibrator plates simultaneously presented approach automatic parting calibrators proposed given calibrator integral plate positions calibrators parting faces identified automatically based recognitions visibility attribute adjacent graphs calibrator cavity surfaces meet machining process requirements calibrators parting process achieve final position calibrator parting faces presented case study presented validate proposed methodology
watermarking protocols designed tracing illegal distributors unauthorized copies found far proposed schemes set two watermarks embedded copy seller sold main potential concerns multiple watermarking image quality would damaged earlier embedded watermarks would destroyed well thanks visual cryptography encodes secret image two shares recovers secret collecting two shares therefore new buyer seller watermarking protocol proposed paper applying technique visual cryptography lei scheme free disadvantages multiple watermarking insertion
within european countries example germany france high proportion students secure work placements part course opportunity develops students strengthens industry academia interactions comparison lags behinds point commented universities minister david willetts recently regards preparing graduates employment difference raises question deficient within partnership models within cementing effective relationship paper consider tactics overcome gap resulting operational challenges focusing particularly undergraduate course development case study used illustrate approach coventry university unipart manufacturing group development beng manufacturing engineering degree effective strategic partnerships require clear shared vision well effective operational model develops lasting relationships set specific resources learning competencies shared vision university company produce work ready graduates graduates require extended graduate training scheme norm achievement vision required consideration physical environments communication operational challenges order create deeper level collaboration partnership result building institute academic research development based unipart manufacturing site coventry new resource see learning environment students based allowing work live industrial projects reinforce taught theory semester long projects proposed company progress mentored university subject specialists industrial workplace mentors teaching model one project week semester resulted series discussions factoring voices three main stakeholders academic institute industry partner students key challenge held interpreting voice really saying really want past experiences show universities industry come together form partnerships differences language terminology created barriers academic hybrids academic transferred professional practice higher education key translators ais ips allowing move elaborative language restrictive language back ensure misunderstanding close frequent interaction students industrial mentors company site built semester long projects brings number new challenges particularly identifying live projects suitable level study rules engagement students gain access shop floor health safety intellectual property rights maintaining general transferable skills company approach resolution dimensions outlined demonstrate work relevant degree programs require unique set competencies develop implement
background vitamin vitamin receptor vdr important metabolic processes affect bone mineral density bmd however effect vdr bsmi polymorphism bmd pediatric patients still unclear methods eligible studies identified following electronic databases pubmed embase cochrane library chinese cnki wanfang databases october data extracted eligible studies associations vdr bsmi polymorphism bmd pediatric patients estimated weighted mean differences wmds confidence intervals cis subgroup analysis ethnicity sensitivity analyses used identify sources heterogeneity results significant difference observed vdr bsmi polymorphism pediatric bmd levels lumbar spine corecessive model wmd significant relationship found dominant recessive codominant models bmd wmd wmd wmd addition found remarkable association bsmi polymorphism bmd levels femoral neck children wmd wmd wmd wmd conclusion meta analysis found vdr bsmi genetic polymorphism correlated bmd level pediatric patients compared allele children genotype less likely lower bmd levels significant difference identified pediatric bmd levels
bed load transport rate gravel bed rivers shows large non gaussian fluctuations even steady flow conditions development high resolution measurement techniques last two decades creates research opportunities study intermittent character bed load transport significance fluctuations paper use impact plate alternative video based technology laboratory applications investigated objective develop simple robust technology run continuously several hours impact plate mounted vertically flume outlet novel nonintrusive configuration reduces uncertainties particle transport rate measurement compared classical configuration configuration impact plate indeed parallel bed vibrations recorded sensor depend great deal features particle motion mode transport angle impact particle velocity two key variables monitored different flume experiments number moving particles bed load transport rate measured using vertical plate sensor image processing impact plate camera found reach level accuracy vertical impact plate therefore efficient measurement technique requires reduced costs computational resources american society civil engineers
current meta analysis investigated extent personality traits changed result intervention primary focus clinical interventions identified studies tracked changes measures personality traits interventions including true experiments prepost change designs interventions associated marked changes personality trait measures average time weeks additional analyses showed increases replicated across experimental nonexperimental designs nonclinical interventions persisted longitudinal follow ups samples beyond course intervention emotional stability primary trait domain showing changes result therapy followed extraversion type therapy employed strongly associated amount change personality traits patients presenting anxiety disorders changed patients treated substance use changed least relevance results theory social policy discussed
introduction protein coupled receptors gpcrs transmembrane receptor proteins allow transfer signals across membrane rheumatoid arthritis autoimmune disease characterized synovitis accompanied inflammatory abnormal immune response gpcrs signaling pathways play significant role inflammatory immune response processes including findings review focused advances gpcrs signaling pathway implicating inflammatory immune response signaling pathways gpcrs adenylyl cyclase cyclic adenosine monophosphate camp include beta adrenergic receptors beta ars camp signaling pathways prostanoid camp signaling pathways regulatory proteins protein coupled receptor kinases grks beta arrestins play important modulatory roles gpcrs signaling pathway gpcrs signaling pathway regulatory proteins implicate pathogenesis process inflammatory immune response conclusion gpcrs camp signal pathways involve inflammatory immune response different signaling pathways mediated different receptors beta pge receptor chemokines receptor adenosine receptor grks beta arrestins crucial proteins regulation gpcrs signaling pathways potential therapeutic targets well strategies modulate gpcrs signaling pathway new development trends
comparison common water management research every table map graph invites comparisons different places variables detailed international comparisons however seem infrequent water resources research assess perceived gap paper searched examples comparative research two water sub sectors two countries using systematic bibliographic mapping procedures focused rural urban water conservation research india united states search methods built upon procedures initially developed fao investment centre advanced systematic review methods search generally confirmed detailed comparative international studies subject review surprisingly greater number comparative studies rural urban water conservation within country search also identified different conservation emphases two countries rainwater harvesting india compared stormwater quality management united states identified unanticipated publications lines comparative water conservation comparative physiology transnational research goes beyond comparison address diffusion innovations research linkages well comparisons although studies also prevalent pattern involves parallel literatures indicate substantial opportunities future comparative transnational research review also identified diffusion international knowledge paths product formal comparative research final section focuses prospects priorities future international inter sectoral research paired multi objective river basin research linkages climate change adaptation disaster risk reduction diffusion water conservation innovations synthesis research urban rural rainwater harvesting different countries
intelligent electrical circuit controlling operation quartz metal halide discharge qmh lamps proposed lamp operated steadily high frequency integrating microcontroller atmega application pattern recognition control system enables lamp turned automatically according environment condition maintain high performance constant power results show efficiency driving circuit approach proposed model provide opportunities design reliable cost effective qmh lamps
knowledge application certain skills related nonverbal communication become important military environment nowadays especially due increasing number troops deployed unfamiliar cultural environments afghan theater operations therefore knowing interact local prideful conservative population indisputable advantage paper approaches certain aspects nonverbal behavior way transmitting messages attitudes within afghan culture defining specific subdivisions concepts nonverbal communication proxemics kinesics oculesics haptics vocalics olfactics chronemics etc paper also includes case study relevant combatant civilian may deployed untamed afghanistan
plant three dimensional computer aided design cad models typically consist logical configuration equipment specifications ports shapes cad models used master information throughout plant entire lifecycle many stakeholders involved lifecycle providing method sharing plant cad models among various stakeholders important standard international organization standardization iso family standards intended support sharing integrating information life process plant therefore important iso support plant cad models order address issue study investigates standardized method exchange plant cad models using iso information requirements regarding plant cad models established iso reference data classes attributes templates extended cover information requirements demonstration proposed method developed prototype platform plant cad models iso loaded retrieved elsevier ltd rights reserved
across three studies examined relationship narcissism prosocial behaviors reasons people engaged specifically examined narcissistic people engaged charitable donations taking advantage naturally occurring mass charitable donation campaign als ice bucket challenge study also examined narcissism related volunteering types prosocial behaviors studies moreover compared contrasted prosocial responses empathic versus narcissistic people studies paper help scholars practitioners determine circumstances reasons narcissistic people may exhibit prosocial behaviors
increased disclosure hiv status shown reduce disease transmission among persons living hiv plhiv hiv related stigma shown reduce hiv disclosure however little known factors may underlie relation hiv related stigma hiv disclosure current study examined emotion dysregulation maladaptive generation processing modulation one emotions relation hiv related stigma sub facets hiv related stigma hiv disclosure among plhiv seeking psychological treatment male african american non hispanic age results indicated past experiences rejection due one hiv status enacted stigma well subjective beliefs regarding plhiv evaluated others public attitudes stigma significantly related hiv disclosure additionally relations moderated emotion dysregulation specifically greater hiv related stigma associated reduced hiv disclosure individuals greater emotion dysregulation however emotion dysregulation moderate relations negative self image shame guilt disclosure concerns hiv disclosure findings suggest emotion dysregulation may play moderating role certain types hiv disclosure
objective study develop viable reliable technique delivering viral vectors rat trigeminal ganglia adult sprague dawley rats used lentiviral vectors containing enhanced green fluorescence protein calcitonin gene related peptide short hairpin rna shrna generated following general anesthesia viral vectors delivered rat trigeminal ganglia using technique described study ray micro computed tomography micro employed verify position needles injecting vectors vivo fluorescence imaging immunostaining enhanced green fluorescence protein performed determine success viral transduction levels calcitonin gene related peptide trigeminal ganglia determined using real time pcr pain levels following injections evaluated using rat grimace scale results show injection needles advanced precisely trigeminal fossa viral vectors successfully transduce trigeminal ganglia moreover levels calcitonin gene related peptide trigeminal ganglia regulated day viral transduction pain levels returned baseline day following injection therefore suggest trigeminal ganglion targeting technique could used delivering genes drugs rat trigeminal ganglia
parameter estimation plays important role modeling system identification however parameter estimation chaotic systems basic differences dynamical systems due butterfly effect paper apply new cost function parameter estimation interesting chaotic system system plane equilibrium belongs newly introduced category dynamical systems systems hidden attractor nonlinear dynamics system described terms equilibria stability phase portraits bifurcation diagram lyapunov exponents order minimize proposed cost function obtain correct parameters use new efficient optimization method krill herd algorithm results show success proposed procedures
ghz uwb radar chip surveillance reconnaissance applications fabricated cmos process uwb radar chip employs equivalent time sampling channel time interleaved sampler architecture offset calibrator bjt based circuit greatly reduce offset issues analog signal processing part employs proposed high speed track hold circuit direct loop back test shows feasibility distance sensing resolution several meter distance chip size consumed supply
iterative algebraic method called state reduction algorithm proposed compute distance spectrum time invariant convolutional codes method based iterative manipulation symbolic adjacency matrix state diagram work defines new adjacency matrices time varying convolutional codes allow application algorithm class codes
objective compare cause health care utilization costs patients schizophrenia treated monthly paliperidone palmitate ppm invega sustenna atypical oral antipsychotic therapy oat methods retrospective claims based analysis among adult california medicaid medi cal patients schizophrenia claims ppm oat july december continuous health plan enrollment year pre post index date ppm oat initiation date baseline characteristics reported descriptively propensity score matching greedy match method used create two matched cohorts treatment patterns cause health care utilization costs month follow period compared two matched cohorts results two well matched cohorts patients produced similar baseline characteristics month follow period ppm patients significantly less likely discontinue treatment switch new therapy ppm patients fewer inpatient visits lower mean hospitalization days days inpatient costs pharmacy costs significantly higher ppm cohort total costs significantly different matched cohorts conclusions patients schizophrenia treated ppm significantly fewer inpatient hospitalizations associated costs significant difference total costs two cohorts study subject limitations associated claims data miscoding inability examine clinical severity etc
aims study investigate associations work stress defined effort reward imbalance eri model diet quality examine potential role commitment personality eri diet relationships cross sectional study conducted random population samples men women age years czech republic russia poland dietary data collected using ffq healthy diet indicator hdi constructed using eight nutrient food intakes hdi components reflect adherence dietary guideline extent imbalance effort reward measured effort reward ratio effort score numerator reward score multiplied factor adjusting unequal number items denominator logistic regression linear regression used assess associations exposures ratio outcomes hdi components hdi adjustment confounders mediators results showed high ratio high significantly associated unhealthy diet quality increase ratio hdi reduced men women increase hdi decreased men women respectively modifying role eri diet relationships non significant improve diet quality workplace multiple level approach combining organisational intervention work stress individual intervention vulnerable personality recommended
protein phosphatases pps counteract kinases reversible phosphorylation events numerous signal transduction pathways eukaryotes type pps ppcs represent major group pps plants recent discovery novel abscisic acid aba receptors abars placed ppcs center stage major signaling pathway regulating plant responses stresses plant development several studies provided deep insight vital roles ppcs various plant processes global analyses ppc gene family model plants contributed understanding genomic diversity conservation across plant species review discuss genomic structural accounts ppcs plants recent advancements interaction paradigm abars sucrose nonfermenting related kinases snrks aba signaling also highlighted addition expression analyses important roles ppcs regulation biotic abiotic stress responses potassium deficiency signaling plant immunity development elaborated knowledge functional roles specific ppcs could exploited genetic manipulation crop plants genetic engineering using ppc genes could provide great impetus agricultural biotechnology sector terms imparting desired traits including higher degree stress tolerance productivity without yield penalty
motor symptoms parkinson disease focal dystonia arise dysfunction basal ganglia improved pallidotomy deep brain stimulation globus pallidus interna gpi however parkinson disease associated greater degree basal ganglia dependent learning impairment dystonia attempt understand observation terms comparison electrophysiology output basal ganglia two conditions use natural experiment offered deep brain stimulation compare gpi local field potential responses subjects parkinson disease compared subjects dystonia performing forced choice decision making task sensory feedback dystonic subjects found auditory feedback associated presence high gamma oscillations nestled negative deflection morphologically similar sharp wave ripple complexes described human rhinal cortex present parkinson disease subjects temporal properties high gamma burst modified incorrect trial performance compared correct trial performance groups exhibited robust low frequency response incorrect trial performance dominant gpi non dominant gpi theta frequency results suggest cellular processes associated striatum dependent memory function may selectively impaired parkinson disease even dopaminergic drugs administered error detection mechanisms preserved
designing clinical trials focused functional constipation therapies understanding normative values populations selected using rome iii criteria important estimating baseline symptom severity power analysis sample size calculations objective review determine normative ranges stool frequency form adults functional constipation rome iii criteria eligible studies reported stool frequency form random effects meta analysis performed subgroup analyses explore sources heterogeneity total studies groups subjects included pooled estimates weekly stools stool form bristol scale heterogeneity high outcomes subgroup analysis revealed weekly bowel movement frequency higher larger smaller studies studies conducted europe compared americas stool form use daily diary versus subject recall sole explanatory variable conclude adults functional constipation significant variation stool frequency form explained part geography study design
background aims ano genital granulomatosis rare chronic granulomatous condition skin causes lymphoedema external genitalia reported association crohn disease mechanisms disease optimal methods treatment poorly understood methods retrospective casenote review male patients ano genital granulomatosis presenting genital lymphoedema performed determine clinical histopathological features condition relationship intestinal crohn disease results combination penile scrotal oedema reported presentation patients patients associated intestinal crohn disease average time symptom onset diagnosis months half cutaneous biopsies contained non caseating granulomas contained intralymphatic granulomas patients responded oral steroids initially recurrence common complete partial response achieved patients treated azathioprine three six patients responded anti tumour necrosis factor tnf therapy small proportion patients required circumcision bulking surgery debilitating disease conclusions ano genital granulomatosis rare condition presents genital lymphoedema frequently protracted delay diagnosis strong association intestinal crohn disease genital lymphoedema associated gastrointestinal symptoms prompt careful evaluation exclude ano genital granulomatosis crohn disease
although system reliability theory high capability quality quantification system reliability optimization sro well developed manufacturing engineering seldom applications found construction industry study aims develop system reliability theory based multiple objective optimization model conduct sro identify cost quality trade solution construction projects first whole construction project treated system composed different work packages second reliability function employed quantify quality performance nonlinear cost reliability function set moreover according physical arrangements among work package system reliability structural function determined third total construction cost minimization system reliability maximization defined multiple objectives particle swarm optimization algorithm employed search pareto optimal solutions final cost quality trade solution selected real construction case used evaluate workability proposed model results fully proven validity practicality elsevier rights reserved
secure parent child attachment may help children overcome challenges growing visual visual intellectual impairment large literature exists provides blueprint interventions promote parental sensitivity secure attachment video feedback intervention promote positive parenting vipp based blueprint adapted several specific risk populations children visual impairment may require additional adjustments study aimed identify themes addressed adapting vipp similar interventions delphi consultation conducted professionals field visual impairment select themes relationship focused intervention themes informed systematic literature search interaction intersubjectivity joint attention exploration play specific behavior themes mentioned delphi group paired visual impairment vision disorders infants young children parents search yielded articles making six themes intervention adaptation specific concrete rich literature six visual impairment specific themes dominated themes interaction intersubjectivity joint attention themes need addressed adapting intervention programs developed populations vipp currently focuses higher order constructs sensitivity attachment
effect geosynthetic layers moisture distribution plastic deformation paved unpaved road sections studied using numerical simulations geosynthetic layers consisted top bottom transport layer geonet nonwoven geotextile referred geocomposite capillary barrier drain previous researchers two geotextile types modeled transport layer woven fiberglass nonwoven polypropylene numerical models verified published results obtained soil geotextile column inclusion geosynthetic layers interface aggregate base course abc subgrade increased suction subgrade decreased abc simulated rainfall event woven fiberglass geotextile led higher suctions abc compared nonwoven polypropylene geotextile geosynthetic layers decreased plastic deformation paved unpaved road sections combined mechanistic hydraulic actions increasing thickness asphalt abc layers decreased reinforcement effect geotextile increasing beneficial hydraulic effect term suction level sections thinner asphalt layer woven fiberglass functioning transport layer decreased plastic deformation profile compared profile nonwoven polypropylene geotextile increasing thickness asphalt layer however reduced difference approximately unpaved sections inclusion woven fiberglass layer decreased plastic deformation approximately profile nonwoven polypropylene geotextrile regardless aggregate base course thickness used analysis american society civil engineers
oil palm important industrial crop usually harvested obtain lipids proteins however biomass source important chemical biomacromolecules several industrial applications aim work extract cellulose nanocrystals cnc cellulose nanofribrils cnf lignin pressed oil palm mesocarp fibers popmf initially fibers acetosolv pulped resulting two fractions lignin rich black liquor cellulose rich pulp lignin recovered black liquor totally chlorine free tcf bleaching applied purify cellulose fibers biomacromolecules characterized using several methods including sem feg sem tem drx gpc zeta potential tga ftir pulping bleaching treatment improved amount crystalline cellulose pulp yielding cnc good thermal stability length diameter aspect ratio lignin presented high purity syringyl rich structure good thermal stability characteristics highlight potential use popmf lignin green building block popmf nanocellulose materials renewable biomaterials elsevier rights reserved
conventional chloride ingress prediction models rely simplified assumptions leading inaccurate estimations reasonable simplifications achieved effects interacting variables clearly known work ensemble methods discover significant parameters control chloride ingress using long term field data developed presented models trained using dataset consisting variables describing concrete mix ingredients fresh hardened properties field conditions well chloride profiles results analyses confirm models able determine optimal subset influential variables best predicts chloride profile input dataset elsevier ltd rights reserved
knowledge social interactions basis informed decision support situations conflict determinant however lower attention given social network interpretation process conflict management approaches main objective work presented identify parties social networks correlate negotiation performance formalized therefore experiment set tried streamline relevant aspects interaction individual environment occur rich sensory environment contextual modalities monitored research explicitly focuses idea ambient intelligence system create scenarios augment possibilities reaching positive outcome taking account role contextualized social relationships various conflict management strategies
study presents selection numerical experimental results producing hollow stepped shafts first part study describes advantages using hollow parts machine design discusses main fields applications next innovative rotary compression method producing stepped axes shafts proposed order estimate technological potential rotary compression performed comprehensive numerical experimental analyses producing hollow stepped shafts new technique first rotary compression process hollow parts modeled numerically finite element method modeling made using simufact forming software numerical results verified experimental tests conducted laboratory conditions experiments performed using machine designed authors present study following variables investigated experiments effect billet wall thickness process quality geometry products variations loads torques experimental results confirmthat rotary compression used produce hollow stepped shafts wide range thicknesses
psoriatic arthritis many patients develop permanent joint damage even prolonged follow led several authors consider possibility subpopulation stayers propensity experience event interest opposed assuming entire population consist movers propensity experience event interest addition recognised damaged joints process may act differently across different joint areas particularly hands feet large joints clinical perspective interest lies identifying possible relationships damaged joints processes joint areas movers estimating proportion stayers joint areas exist purpose paper proposes novel trivariate mover stayer model consisting mover stayer truncated negative binomial margins patient level dynamic covariates random effects models movers stayers respectively model extended two level mover stayer structure margins nature stayer property investigated particularly attractive feature proposed models optimisation routine required model fitting procedures authors statistics medicine published john wiley sons ltd
whilst many vertebrates appear externally left right symmetric arrangement internal organs asymmetric zebrafish breaking left right symmetry organised kupffer vesicle approximately spherical fluid filled structure begins form embryo hours post fertilisation crucial component zebrafish symmetry breaking establishment cilia driven fluid flow within however still unclear dorsal ventral equatorial cilia contribute global vortical flow flow breaks left right symmetry mechanical transduction morphogen transport fully answering questions requires knowledge three dimensional flow patterns within quantified previous work study calculate analyse three dimensional flow consider flow individual groups cilia find anticlockwise flow arise purely excess cilia dorsal roof ventral floor showing vortical flow stabilised dorsal tilt equatorial cilia show anterior clustering dorsal cilia leads around faster flow anterior posterior corner argue flow features supportive symmetry breaking mechano sensory cilia suggest novel experiment test hypothesis new understanding flow propose experiment reverse flow within potentially induce situs inversus
comorbidity borderline personality disorder bpd antisocial personality disorder aspd well established disorders share many similarities however also differences across disorders notably bpd diagnosed frequently women aspd men investigated comorbidity bpd aspd attributable discrete disorders expression common underlying processes model comorbidity true across sex using clinical sample drug users residential substance abuse treatment tested competing models explore whether comorbidity aspd bpd represented single common factor correlated factors bifactor structure involving general disorder specific factors next tested whether resulting model meaningful examining relationship criterion variables previously reported associated bpd aspd bifactor model provided best fit invariant across sex overall general factor bifactor model significantly accounted large percentage variance criterion variables whereas bpd aab specific factors added little models association general specific factor criterion variables equal men women results suggest common underlying vulnerability accounts comorbidity bpd aab across sex common vulnerability drives association psychopathology maladaptive behavior turn implications diagnostic classification systems treatment general scientific summary study found men women borderline bpd antisocial personality disorders aspd show large degree overlap little uniqueness commonality bpd aspd mainly accounted associations criterion variables suggests bpd aspd show large common core accounts comorbidity
early detection diagnosis knee osteoarthritis football players preventive measures delay cartilage degeneration crucial prolong football players careers reduce waste coaching medical resources study intended use immunochromatographic urine strip together international knee documentation committee ikdc subjective knee evaluation form western ontario mcmaster universities osteoarthritis womac index assess therapeutic efficacy intra articular injections hyaluronic acid knee football players football players showed lower ikdc womac scores compared healthy subjects players demonstrated significantly improved ikdc scores womac scores signifying improvement knee function injections importantly player improvements detected reflected urine strip results revealed combined immunochromatographic urine strip ikdc womac could used assess therapeutic efficacy injections
laboratory tests geosynthetic reinforced soil aggregate systems carried many researchers understand improvement bearing resistance soil aggregate systems geosynthetic reinforcement california bearing ratio cbr test one among common laboratory tests adopted purpose paper presents influence sample size anchorage reinforcement cbr test tests carried using conventional modified cbr moulds without anchorage reinforcement clay subgrade aggregate subbase simulated tests geosynthetic layer placed interface modified set double size conventional set provision anchor reinforcement three different types geosynthetics namely geotextile biaxial geogrid geonet used tests size mould significantly affected test results effect anchorage reinforcement bearing resistance reinforced soil aggregate systems significant increase sample size reduced boundary interference otherwise resulted prediction secant modulus reinforced systems effect pronounced weaker reinforcement materials
user authentication crucial security systems although many complex secure passkey based authentication mechanisms majority users prefer employing simple passwords viable rubber hose attacks image sequence based passwords introduced overcome issues textual passwords objective work evaluate cognitive memory performance image based user authentication systems via eeg recordings image sequence training task observed increased activity alpha rhythms channel bins augmented levels beta rhythms channels suggesting users personalized authentication alpha numeric password based logins linking potential roles implicit explicit sequence learning improving human user authentication
recent study reported construction management market grown competitive environment identifying company competitive position enables study competitor strategies ability select suitable path profitability study suggests methodology analyze topological competiveness based social relationships firms modeled according four subnetworks joint contract networks linked directly firms public private networks linked indirectly owners building civil networks linked indirectly work type study proposes analytical framework measuring topological competiveness four perspectives network topology among subnetwork centralities structural positions among firms cohesive subgroups strong relations subnetwork structural equivalence among firms using cases korean construction management projects empirical analysis topological competiveness validated methodology diagnose competitiveness select suitable relationships competitors create company growth
use design software inventor established mechanical structure finite element model laser anti counterfeit platform focusing mechanism production manufacturing engineering modal analysis static analysis mechanism found natural frequency vibration modes structure focusing mechanism proved mechanism design reliable stable avoid failure focusing caused mechanical resonance provided basis optimization design production manufacturing engineering
objectives obesity may affect efficacy contraceptives examined weight body mass index bmi prevalence obesity among female contraceptive clients health centers secondary aim analyze differences contraceptive method use obesity status study design cross sectional study using identified electronic health record data family planning centers analyzed contraceptive visits made females aged years results total clients bmi mean body weight mean bmi total bmi levonorgestrel emergency contraception may become less effective obese clients higher odds using tier tier contraceptive method lower odds using tier hormonal method non obese clients conclusions half contraceptive clients would categorized overweight obese contraceptive method choices differed obesity status elsevier inc rights reserved
qualitative interviews young women attending community colleges used address women desire pregnancy vary consistently use contraception based analysis women sexual histories argue five factors key promoting discouraging consistent use contraception efficacy women ability put intention contracept practice actions attitudes male partners long term relationship whether women experience side effects misinformation erroneous reasoning pregnancy risk variations factors combine different times women lives explain much patterns contraceptive consistency
application systems internet things iot real time monitoring control systems need realized wireless communications machine machine especially harsh application scenarios data link communication also critical effect system application paper wireless directional data link smart temperature recording reported radio frequency hardware employed consists nrfl wireless transceivers rfx amplifiers matching network sand antennas microcontroller unit mcu based stmfvet chip controls nrfl four pin serial peripheral interface spi realize directional data link sensor data sampled bit analogue digital converters adcs communication realized interrupt request irq signal nrfl changes periodically look table linear optimization method also implemented improve accuracy adc data directional data link applied wired heating control system results show temperature data transmitted received distance open environment indoor complex environment hardware implemented real time temperature data displayed computer handheld device wireless communication control thus demonstrated
instructional strategies prompts requests clarification explicit feedback counter social desires autonomy appreciation threaten face receiver report online experiment readers perceive instructional face threats accept appropriate one hundred twenty three participants read online tutor tutee discourse systematically varied tutor politeness containing different types face threats face threats either mitigated politely expressed without redress participants rated perception tutor tutor contribution provided alternative formulations presented face threats results showed beneficial tutors mitigate instructional face threats finding deserves attention tutor role extent legitimate face threats discussion examines formulations influence person perception practical conclusions drawn instructional online settings
aims objectives examine perspectives health professionals different disciplines clinical handover background ineffective handovers cause major problems relating lack delivery appropriate care design prospective cross sectional design conducted using survey clinical handover practices methods health professionals employed public metropolitan hospitals public rural hospitals community health centres involved sample comprised doctors nurses allied health professionals including physiotherapists social workers pharmacists dieticians midwives employed western australia new south wales south australia australian capital territory survey sought information health professionals experiences clinical handover perceived effectiveness clinical handover involvement patients family members health professionals ability confirm understanding clarify clinical information role modelling behaviour health professionals training needs adverse events encountered possibilities improvements results health professionals participated response rate represented professions nursing medicine allied health many health professionals reported aware adverse events noticed poor handover significant cause differences existed health professions terms effectively gave handover perceived effectiveness bedside handover nonbedside handover patient family involvement handover respondents confirmation understanding handover perspective observation senior health professionals giving feedback junior health professionals awareness adverse events severity adverse events relating poor handovers conclusions complex barriers impeded conduct effective handovers including insufficient opportunities training lack role modelling lack confidence understanding handover processes
various online systems offer lightweight process creating accounts confirming mail address users easily join minimum effort however attacker subvert process obtain multitude fake accounts use malicious purposes puzzle based solutions proposed limit spread fake accounts establishing price terms computing resources per identity requested although effective distinguish requests coming presumably legitimate users potential attackers also lead significant waste energy computing power paper build adaptive puzzles complement waiting time introduce green design lightweight long term identity management balances complexity assigned puzzles based reputation origin source identity requests reduces energy consumption caused puzzle solving also take advantage lessons learned massive distributed computing come design makes puzzle processing useful based set experiments show solution provides significant energy savings makes puzzle solving useful task compromising effectiveness limiting spread fake accounts elsevier rights reserved
monolayer two dimensional materials promising optical properties hold potential solar absorbers photovoltaic devices efficient solar absorbers high absorption especially wavelengths slightly smaller semiconductor bandgap wavelength spectrum solar cells higher internal quantum efficiency lower energy loss lattice vibration resultant higher power conversion efficiency materials integrated nanophotonic structures enhance absorption fabrication challenges hindered practical applications structures theoretically experimentally demonstrated simple methodology design efficient material generally sub nanometer planar optical absorbers placing sub nanometer film either onto transparent layer metallic film substrate structure transparent layer substrate structure oblique sunlight illumination show always exist pair transparent layer thickness incident angle structures achieve absorption broadband angle robust absorption structure narrowband structure absorption times greater prior theoretical demonstrations achieved monolayer mos near band edge demonstrate material versatility even materials low losses counter intuitive conventional absorber designs material solar cells designed power conversion efficiency four fold increase compared prior designs proposed methodology applicable numerous materials atomic layer sub nanometer thicknesses paves way efficient sub nanometer thick energy harvesting devices simple planar structures
background purpose embolic stroke undetermined source esus designates patients nonlacunar cryptogenic ischemic strokes embolism likely stroke mechanism hypothesized anticoagulation efficacious antiplatelet therapy secondary stroke prevention esus patients review available information esus methods systematic literature review assess frequency esus patient features prognosis using pubmed present unrestricted language results basis studies reported frequency esus ranged ischemic strokes averaging studies involving esus patients mean age years women mean nih stroke score stroke onset studies esus patients esus patients treated antiplatelet therapy follow annualized recurrent stroke rate averaging per year mean follow years studies esus patients conclusions esus comprises ischemic stroke patients ischemic stroke meeting criteria esus relatively young compared ischemic stroke subtypes average minor strokes consistent small emboli retrospective methods available studies limit confidence stroke recurrence rates support substantial per year rate stroke recurrence mostly antiplatelet therapy important need define better antithrombotic prophylaxis frequently occurring subtype ischemic stroke
many dysfunctional chronic pain conditions overlap review describes different modes chronic deregulation adaptive response stress may common factor conditions several types dysfunction identified within hypothalamo pituitary adrenal axis basal hypercortisolism hyper reactivity basal hypocortisolisrn hypo reactivity neuroactive steroid synthesis another component adaptive response stress dehydroepiandrosterone dhea sulfated form dhea progesterone derivatives synthetized cutaneous nervous adipose cells neuroactive factors act locally may role localization symptoms levels vary central nervous system periphery persistent changes neuroactive steroid levels precursors induce localized neurodegeneration autonomic nervous system another component stress response dysfunction chronic stress responses expressed decreased basal parasympathethic activity increased basal sympathetic activity sympathetic hyporeactivity stressful stimulus immune genetic systems also participate helper cells secrete pro inflammatory cytokines beta ifn gamma tnf alpha whereas secrete anti inflammatory cytokines igf chronic deregulation balance occur favor anti pro inflammatory direction locally systemically individual vulnerability stress due environmental factors also genetically influenced genetic polymorphisms epigenetics main keys understanding influence genetics response individuals constraints elsevier ltd rights reserved
background short lasting unilateral neuralgiform headache attacks conjunctival injection tearing sunct autonomic symptoms suna grouped together within trigeminal autonomic cephalalgias tacs however sunct suna phenotype management overlap trigeminal neuralgia additionally broad variety cerebral pathologies reportedly able trigger either sunct like pain emerging structural neuroimaging findings suggest possible role neurovascular conflict trigeminal nerve sunct supporting aetiological pathophysiological overlaps among sunct suna case report present first case coexisting chronic sunct like phenotypes caused haemorrhagic infarct dorsolateral medulla discussion light case perturbation dorsolateral medullary circuits may constitute important pathophysiological component supporting unifying nosological hypothesis considers sunct suna clinical variants disorder
using machine learning methodologies analyze eeg signals becomes increasingly attractive recognizing human emotions objectivity physiological data capability learning principles modeling emotion classifiers heterogeneous features however conventional subject specific classifiers may induce additional burdens subject preparing multiple session eeg data training sets end developed new eeg feature selection approach transfer recursive feature elimination rfe determine set robust eeg indicators stable geometrical distribution across group training subjects specific testing subject validating set introduced independently determine optimal hyper parameter feature ranking rfe model aiming controlling overfitting effectiveness rfe algorithmfor cross subject emotion classification paradigmhas validated deap database linear least square support vector machine classifier implemented performance rfe compared several conventional feature selection schemes statistical significant improvement found classification rate score achieve arousal valence dimensions respectively outperform several recent reported works database end rfe based classifier compared two subject generic classifiers literature investigation computational time classifiers indicates accuracy improvement rfe cost longer training time
bright light therapy used primary treatment seasonal affective disorder however mechanisms underlying antidepressant effect fully understood previously found cbl mice exhibit increased depression like behavior short day condition lowered brain serotonin content study analyzed effect bright light depression like behaviors brain serotonergic system using cblj mice mice maintained bright light treatment daily exposure week reduced immobility time forced swimming test increased intake saccharin solution saccharin intake test however light treatment modify content selective uptake amygdala temporal patterns core body temperature wheel running activity throughout day next experiment attempted enhance effect bright light using serine precursor serine acts methyl naspartic acid receptor coagonist daily subcutaneous injection serine weeks prior bright light strongly reduced immobility time forced swimming test suggesting synergistic effect light serine furthermore bright light increased total number immunoreactive cells cells colocalized fos immunosignals several subregions raphe nuclei effects potentiated prior injection serine data suggest bright light may elicit antidepressant like effect via enhanced signals brain serine enhance effects elsevier inc rights reserved
growing use renewable energy sources distributed generation systems rapidly spreading embedding distribution network may costly due grid reinforcements control adjustments required order maintain electrical network reliability deterministic load flow calculations usually employed assess allowed penetration distribution network order ensure current voltage limits exceeded however calculations may overlook risk limit violations due uncertainties operating conditions networks overcome limitation related injection demand profiles present paper addresses problem penetration monte carlo technique accounts intrinsic variability electric power consumption power absorbed load medium voltage network characterized load variation curve probabilistic load flow used computing maximum power connected bus without determining violation electric constraints distribution network studied comparison provided results deterministic load flow probabilistic load flow analyses elsevier ltd rights reserved
beta amyloid peptide beta induced neurotoxicity considered hallmark pathogenesis alzheimer disease present study demonstrated neuroprotective role receptors beta induced neurotoxicity cells receptor agonist emd antagonist used pharmacological tools nmda receptor antagonist memantine used reference standard beta induced apoptosis increased reactive oxygen species ros generation impaired neurite outgrowth cells pre treatment emd significantly protected neuronal cell death maintaining higher cell viability attenuation intracellular ros compounds significantly prevented beta induced impairment neurite outgrowth cells similarly memantine prevented beta induced neurotoxicity cells findings suggest receptor ligands protected neurons beta induced toxicity reducing ros prevention impairment neurite outgrowth therefore receptor could important disease modifying therapeutic target
aim systematic review meta analysis testing whether low versus high doses second generation antipsychotics sgas associated different clinical benefits harms acute treatment bipolar depression included clinical trials comparing different doses sga monotherapy bipolar depression sgas defined daily doses used define high low doses clinical benefit outcomes included improvement response remission rates montgomery asberg depression rating scale clinical harm outcomes included cause adverse effect related discontinuation rates data seven clinical trials testing high low doses quetiapine trials cariprazine lurasidone ziprasidone trial showed differences lower higher doses selected sgas improvement response remission rates without significant heterogeneity across studies subgroup analyses based single sgas confirmed clinical benefit comparability low high doses however clinical harm favorable differences low doses cause adverse effects related discontinuation found sum meta analysis showed although benefits found terms symptoms improvement response remission rates clear disadvantages prescribing higher rather lower doses selected sgas uniform methodological strength studies increases confidence findings data need integrated individual patient characteristics clinical urgency adverse effect sensitivity optimize management acute bipolar depression elsevier ltd rights reserved
order develop computationally efficient implementation maximally permissive deadlock avoidance policy dap complex resource allocation systems ras recent approach focuses identification set critical states underlying ras state space referred minimal boundary unsafe states availability information enables expedient one step lookahead scheme prevents ras reaching outside safe region work presented paper seeks develop symbolic approach based binary decision diagrams bdds efficiently retrieving minimal boundary unsafe states underlying ras state space presented results clearly demonstrate symbolic computation enables deployment maximally permissive dap complex ras large structure state spaces limited time memory requirements furthermore involved computational costs substantially reduced pertinent exploitation special structure exists considered problem note practitioners key component real time control many flexibly automated operations management allocation finite set reusable resources among set concurrently executing processes allocation remains dead lock free corresponding problem known deadlock avoidance resolution way retains sought operational flexibilities challenging problem due inability easily foresee longer term implications imminent allocation large sizes relevant state spaces prevent online assessment implications exhaustive enumeration recent methodology sought address complications offline identification storage set critical states underlying state space renders efficient safety assessment given resource allocation results presented paper extend strengthen methodology complementing techniques borrowed area symbolic computation techniques enable compressed representation underlying state spaces various subsets operations involved pursued computation
acknowledged knowledge knowledge bases important part coach athlete learning coach athlete relationship crucial knowledge created shared used said knowledge nutrition constructed elite gymnasts would seem particularly important culture long associated weight control practices disordered eating paper provides insight ways brazilian olympic gymnasts construct ideas pertaining nutritional knowledge across generational periods significant organisational change women artistic gymnastics brazil occurred included introduction dieticians drawing upon different knowledge types paying attention coaching context life histories olympic gymnasts used open window knowledge construction pertaining nutrition three generations gymnasts findings draw attention two main illustrative themes firstly coaches personal knowledge whilst perceived incomplete gymnasts reinforced narrative weight loss gymnasts regardless generation secondly younger generations gymnasts perceived introduction dieticians structured provision enabled use better structured knowledge sense increased autonomy corporeal learning via construction tacit embodied knowledge leading healthier practices reflections given role coach dieticians pedagogical actions continued reshaping knowledge elite gymnastics
major challenge urban water management identification cost effective future proof strategies cope rapid urbanization changing environmental conditions water quantity modelling forms key element development strategies conventional detailed hydrodynamic models well suited use decision support systems due several important drawbacks therefore paper presents novel computationally efficient conceptual modelling approach sewer water quantity simulations modular framework considered combines well established model structures machine learning techniques flexible framework ensures even complex flow dynamics emulated accurately accompanying software tool developed facilitate model configuration example full hydrodynamic sewer model city belgium transformed conceptual model model delivered precise results calculation time times shorter detailed model
purpose aim study analyze stabilometry athletes indoor season order determine whether injured athletes show different stabilometric values injury non injured athletes two different training periods volume pre competition periods subjects subjects athletes unicaja athletic club trained regularly methods end preseason volume periods athletes subjected bipodal monopodal stabilometry addition injuries happening periods performing stabilometry volume pre competition periods tracked results variance analysis bipodal stabilometric measurements taken end preseason period showed athletes higher values center pressure spread variables suffered injuries volume period right leg monopodal stabilometric measurements taken end volume period showed athletes higher values center pressure position variables suffered injuries pre competition period conclusion athletes showing worst values center pressure spread variables prone sports injuries subsequent training period monopodal measurements athletes poorer mediolateral stability prone injuries subsequent training period
study compared similarities gaps strategies performance related food allergies alabama restaurants online questionnaires completed managerial staff united states samples strategies accommodate food allergy clients mean food allergy knowledge scores united states maximum score samples viewed employees lack commitment interest barriers training provision sample provided employee food allergy training compared sample studies needed identify best practices food allergy management apply restaurant industry
development premature ovarian failure subsequent infertility possible consequences chemotherapy use pre menopausal women early stage breast cancer among available strategies fertility preservation pharmacological protection ovaries using luteinising hormone releasing hormone analogues lhrha chemotherapy potential restore ovarian function fertility anticancer treatments however possible efficacy clinical application strategy highly debated last years following availability new data controversial topic panel italian association medical oncology aiom clinical practice guideline fertility preservation cancer patients decided apply grades recommendation assessment development evaluation grade methodology around relevant current question clinical utility temporary ovarian suppression lhrha chemotherapy strategy preserve ovarian function fertility breast cancer patients answer question preservation ovarian function fertility judged critical outcomes decision making three possible outcomes harm identified lhrha associated toxicities potential antagonism concurrent lhrha chemotherapy lack prognostic impact chemotherapy induced premature ovarian failure according grade evaluation conducted result strong positive recommendation favour using option preserve ovarian function fertility breast cancer patients present manuscript aims update summarise evidence use strategy light new data published january according grade process elsevier ltd rights reserved
nonsuicidal self injury nssi defined deliberately damaging one body tissue without conscious suicidal intent nssi robust predictor suicidal ideation attempts adults nssi associated directed violence adolescent populations link nssi interpersonal violence adults less clear current study examined cross sectional relationship nssi past year interpersonal violence among help seeking veterans posttraumatic stress disorder ptsd veterans reported recent history engaging cutting hitting burning significantly likely report making violent threats engaging violent acts including use knife gun past year veterans without nssi nssi uniquely associated interpersonal violence controlling variety dispositional historical contextual clinical risk factors violence including age race socio economic status marital status employment status combat exposure alcohol misuse depression ptsd symptom severity reported difficulty controlling violence findings suggest clinicians working veterans ptsd review nssi history conducting risk assessment violence
recent years structural applications bonded joints increased remarkably owing several advantages relative joining methods consequence development improved models provide design efficiency time increase confidence designers acquires special relevancy recent developments considering cohesive continuum mixed mode damage models demonstrated methods able deal several details inherent mechanical behaviour bonded joints methods allow simulation damage initiation propagation combining classical strength materials approaches fracture mechanics concepts work several different mixed mode cohesive laws adapted different types adhesives mechanical behaviour presented discussed effectively mechanical behaviour brittle moderately ductile adhesives well simulated means simple bilinear cohesive law adhesives pronounced ductile behaviour require sophisticated cohesive laws aspects regarding determination cohesive parameters also given special attention present paper continuum mixed mode damage model also presented using bilinear softening cohesive law model advantageous since properties degradation takes place inside solid elements used simulate adhesive allows evaluation specific issues like influence asymmetric propagation joint mechanical behaviour realistic manner important conclusions advantages drawbacks methodologies drawn
offer psychoanalytic perspectives hypotheses contribute understanding family interventions rarely offered psychosis despite decades evidence family difficulties often predate onset psychosis skilled family interventions least effective medication reducing relapse rates contend often unbearably disturbing families even consider possibility contributed vulnerability member psychosis professionals fear accusations blaming multisystem defences involving families professionals shift explanations psychosis reducing disorder brain chemistry somewhat exclusively allowing logical consequence pharmacological interventions make sense summarize unfortunate consequences defences suggest denial important difference describing possible family environmental contributing factors psychosis attributing blame whole team training involves families social networks highly respectful humane manner overcomes obstacles several decades increasingly successful research finnish psychodynamically orientated need adapted approach psychosis resulting recent global interest open dialogue indicate effective way engaging families achieving superior outcomes returning individuals social engagement students employment
several studies examined effect renewable portfolio standard laws renewable generation states previous literature assessed potential spatial dependence policies using recent spatial panel methods paper estimates number econometric models examine impact rps policies spatial autocorrelation taken account consistent previous literature find rps laws significant impact renewable generation within state however find evidence state rps laws significant positive impact share renewable generation nerc region whole findings provide evidence electricity markets efficiently finding lowest cost locations serve renewable load states stringent rps laws addition results suggest rps laws may effective tools environmental policy economic development
purposethe aim study give overview prevalence contact allergy active ingredients excipients topical medications across europe methodsretrospective analysis data collected european surveillance system contact allergies substances applied consecutively patch tested patients departments european countries resultsin view varying composition baseline series used previously mentioned departments countries lanolin alcohols patients sodium metabisulfite patch tested topical agents covered study among positive allergic reactions commonly observed sodium metabisulfite positive followed propolis compositae mix lanolin alcohols caine mix iii benzocaine cinchocaine tetracaine conclusionsseveral substances warrant routine screening contact allergy patch testing baseline series however view vast number topical agents additional patch testing suspect topical drug preparations including natural remedies cosmetics warranted event positive test pharmaceutical product single ingredients tested individually precisely identify hapten copyright john wiley sons ltd
sharma investigated performance two layered fractional order fuzzy logic controller foflc link rigid planer robotic manipulator payload work performance foflc compared two layered flc flc single layered flc flc conventional proportional integral derivative pid controllers trajectory tracking model uncertainties disturbance rejection comment pointed work several missing essential parameters therefore possible reader validate claimed results sharma six numerical values three gains used two pid controllers found unreported addition six gains used two flcs since performances pids flcs highly dependent tuned gains concluded reported performances controllers validated elsevier rights reserved
introduction little reported demographic clinical features major depressive disorder mdd comorbid dysthymia chinese patients study examined frequency comorbid dysthymia chinese mdd patients together demographic clinical correlates prescribing patterns psychotropic drugs methods consecutively collected sample patients mdd examined major psychiatric hospitals china patients demographic clinical characteristics psychotropic drugs prescriptions recorded using standardized protocol data collection procedure diagnosis dysthymia established using mini international neuropsychiatric interview medications ascertained included antidepressants antipsychotics benzodiazepines mood stabilizers results one hundred three patients fulfilled criteria dysthymia multiple logistic regression analyses compared non dysthymia counterparts mdd patients dysthymia depressive episodes atypical features including increased appetite sleep weight gain frequent lifetime depressive episodes less likelihood family history psychiatric disorders significant difference pattern psychotropic prescription groups conclusions important differences demographic clinical features comorbid dysthymia chinese mdd patients compared previous reports clinical profile found study implications treatment decisions
introduction fifth edition diagnostic statistical manual mental disorders dsm includes significant revision eating disorders objective study compare distribution diagnosis adolescents according dsm dsm criteria second objective study psychopathological differences patients based dsm whose diagnosis changed applying dsm criteria methodology one hundred one adolescents diagnosed mean years evaluated clinical interviews scales eating psychopathology perfectionism anxiety depression results applying dsm criteria led significant decrease diagnosed cases eating disorders otherwise specified ednos significant increase anorexia nervosa bulimia nervosa significant psychopathological differences found patients diagnosed based dsm criteria newly diagnosed based dsm criteria discussion using dsm criteria adolescents leads significant decrease frequency ednos diagnosis similar psychopathological characteristics observed patients diagnosed based dsm switched ednos based dsm conclude new criteria dsm valid adolescent population
aim study evaluate possible effect lipocalin thrombotic events polycythemia vera essential thrombocythemia patients samples patients collected rna based method used evaluate relative gene expression level lipocalin samples available evaluation drawing cut point level relative expression rate patients elevated lipocalin expression thrombotic events course disease based data high lipocalin expression level seems strong positive predictive value thrombotic events patients polycythemia vera essential thrombocythemia lipocalin may useful thrombotic risk stratification patients elsevier ltd rights reserved
aimpsychiatric side effects main reason discontinuation interferon ifn based therapy recent developments near infrared spectroscopy nirs enabled non invasive clarification brain functions psychiatric disorders prospectively evaluated brain activation chronic hepatitis patients without ifn based therapy using nirs verbal fluency task vft methodsthe relative concentrations oxygenated hemoglobin measured patients completed questionnaire survey start treatment weeks treatment using nirs resultsthe vft performance change among two groups patients ifn based therapy showed significantly lower activation vft frontal channels weeks start treatment control center epidemiologic studies depression scale scores significantly higher weeks start treatment although major depressive symptoms found conclusionthe decrease oxygenated hemoglobin concentrations frontal lobe detected using nirs study reflects hypofunction frontal lobe functional decline caused ifn based therapy may associated prodromal phase depression
algorithms shape imaginary practice security proliferation point shift political rationality security nature extent shift article argues efforts strengthen global health security major drivers development proliferation new algorithmic security technologies response seeming epidemic potentially lethal infectious disease outbreaks including hiv aids severe acute respiratory syndrome sars pandemic flu middle east respiratory syndrome mers ebola zika governments international organizations using several next generation syndromic surveillance systems rapidly detect new outbreaks globally article analyses origins design function three internet based surveillance systems program monitoring emerging diseases global public health intelligence network healthmap article shows newly introduced system became progressively reliant upon algorithms mine ever growing volume indirect data sources earliest signs possible new outbreak gradually propelling algorithms heart global outbreak detection turn algorithm marks significant shift underlying problem nature role knowledge contemporary security policy
objectives studies assessed technology aided program support mild physical exercise simple occupational activity participants moderate severe alzheimer disease methods study included participants perform leg raising response study included participants sort objects different containers program ensured received positive stimulation contingent responses reminders prompts periods nonresponding study carried according nonconcurrent multiple baseline design across participants results program successful supporting mild physical exercise activity objects groups participants respectively participants also showed signs positive involvement smiles verbalizations sessions moreover staff personnel rated program impact positively conclusion program may considered practical resource supporting positive engagement persons moderate severe alzheimer disease
objective ascertain efficacy tolerability carbamazepine cbz sodium valproate vpa lamotrigine ltg levetiracetam lev using ukaed register www ukaed info methods patients cbz vpa ltg lev healthy control subjects ctr medication extracted patients anonymously provided information seizure type frequency completed liverpool adverse event profile laep results number seizure free patients last weeks overall cbz vpa ltg lev generalized epilepsy cbz vpa ltg lev localization related epilepsy cbz vpa ltg lev mean laep scores cbz vpa ltg lev ctr mean laep significantly higher patients reporting depression patients active epilepsy patients without depression remission central nervous system cns adverse effects including memory problems difficulty concentrating depression unsteadiness restlessness feelings anger shaky hands dizziness significantly frequent cbz vpa ltg lev ctr feeling anger significantly frequent lev depression significantly frequent cbz compared drugs conclusion internet based register self reported efficacy tolerability cbz vpa ltg lev similar self reported cns adverse effects significantly frequent controls addition anger associated lev depression cbz confounding factors depression uncontrolled epilepsy
nosql phenomenon taken database application world storm growth penetration nosql applications driven silicon valley giants like facebook twitter yahoo google linkedin created unprecedented database revolution inspire smaller companies join nosql bandwagon expansion growth databases adding glory success many corporate departments pertinent explore security aspects new era databases confidentiality integrity availability cia foundation data protection privacy paper sincere attempt made survey analyze assess maturity nosql databases lens cia triad concept cia origins relational databases important understand survey delineate security capabilities new generation databases terms cia fulfillment
paper presents real time open software simulation framework dedicated analysis control systems deployed distributed execution resources wireless links able consistently simulate parallel numerical devices real time tasks communication links evolution controlled continuous time plant applied foresee future enhancements functional electrical stimulation fes system used therapy rehabilitation substitution disabled people distributed control system using electrodes interface digital control system livings hence whole system gathers continuous time muscles nerves discrete time controllers wireless links components design process realistic simulation remains precious tool ahead real experiments check without danger implementation matches functional safety requirements simulation tool especially devoted joint design analysis control loops real time features
present new matrix spectral problems based real special orthogonal lie algebra construct corresponding soliton hierarchies bymeans zero curvature equations associated spectral problems aid symbolic computation maple new soliton hierarchies kaup newell type ablowitz kaup newell segur type andwadati konno ichikawa type obtained illustrate use copyright johnwiley sons ltd
determine prevalence predictors outcomes steroid induced hyperglycemia hospitalized patients hematologic malignancies performed retrospective analysis patients hospitalized four hematology services bone marrow transplant service received systemic steroids month period mean glucoses days maximum glucose calculated total daily steroid dose converted equivalent dose dexamethasone hyperglycemia defined glucose mmol days examined associations variables using spearman correlations multivariable linear regression patients included analysis mean age years males caucasians prevalence hyperglycemia eight patients received intravenous insulin patients without diabetes steroid dose equivalent dexamethasone longer acting steroids caused greater degree hyperglycemia compared dose maximum glucose predictor hospital length stay among patients without diabetes diabetes acute leukemia stem cell transplant hematologic malignancies significant differences mortality outcomes groups without hyperglycemia hyperglycemia common patients hematologic malignancies require frequent corticosteroids higher steroid dose long acting steroids caused greater degree hyperglycemia maximum glucose predictor length stay significant patients without diabetes acute hematologic malignancy stem cell transplant
paper explore barriers health fat people shifting focus fat people neoliberal principles replaced focus instead structural institutional policies attitudes practices includes impact stigma health treatment health seeking behavior fat people example consider role provider anti fat attitudes confirmation bias play failure provide evidenced based healthcare fat patients autoethnographic paper provides opportunity read research perspective fat scholars framed questions fat people health health state set behaviors commodity performance perhaps new social contract written autoethnographic paper one aspect evidence provided recorded experiences two fat authors includes writing notes journals compiled repeated experiences medical professionals family community framed feminist standpoint supported literature drawn fat studies public health obesity research interdisciplinary fields valuable opportunity present extended account fat discrimination impact stigma fat people face medical profession sectors community written fat individuals paper concludes considering health pathways available fat people special attention paid whether bacon aphramor health every size paradigm provides path health fat individuals
last years multi story buildings msbs introduced arba minch ethiopian cities condominium houses constructed edge city boundaries standardized design including flush toilets water supply scheme place hardly cope water demand inside new buildings shortage water causes many problems bathing washing flushing toilets unhygienic conditions inducing toilet blockage smells houses infection lead negative effect health people moving condominium houses problems arise objective paper study feasibility rainwater harvesting rwh additional water supply msbs two msbs selected pilot plot bekele mola site case flashing toilet rainwater could save month potable water means reduce use potable water non potable water needs household rwh system recovering water demand flushing water demand maximum habitants pilot buildings supply limited amount rainfall size catchment area addition installation price relatively high
research sexual changes understood dysfunctions versus normal change remains scarce namely societies traditional gender roles persist among growing diversity sexual relationships practices article discusses controversies sexual function definitions sociology diagnosis sexual scripting theoretical frameworks drawing structured interviews primary healthcare users greater lisbon area followed depth interviews subsample heterosexual men women low level agreement found scores widely used instruments sexual function evaluation epidemiology studies self diagnosis may understood challenge predominant biomedical model need conceptualize sexual dysfunctions organic dysfunctions implications research practice results show individuals challenge illness concepts sexual dysfunction diagnoses treatments also construct sexual problems based impacts daily life demonstrating permanence traditional social scripts operate definitions sexual function one way understand gender embodied social structure get adequate practice problem particularly portuguese society sexuality remains highly gendered
senescence marker protein smp decreases androgen independently aging lactone hydrolyzing enzyme gluconolactonase gnl involved vitamin biosynthesis present study bone properties smp gnl knockout mice deficiency vitamin synthesis investigated reveal effects smp gnl exogenous vitamin supplementation bone formation mineral content bmc mineral density bmd mandible femur smp gnl wild type mice months age without vitamin supplementation measured dual energy ray absorptiometry body bone weight age groups decreased became significantly lower wild type mice bones smp gnl mice rough porous bmc bmd significantly wild type oral supplementation vitamin eliminated differences body weight bone weight bmc bmd smp gnl wild type mice age results indicate bone degeneration smp gnl mice caused lack vitamin mouse strain appropriate model bone metabolism humans ability synthesize vitamin
construct team optimal estimation algorithms distributed networks state estimation finite horizon mean square error mse sense distributed collection agents processing cooperation capabilities agents observe noisy samples desired state linear model seek learn state interacting although problem attracted significant attention studied extensively fields including machine learning signal processing well known strategies achieve team optimal learning performance finite horizon mse sense end formulate finite horizon distributed minimum mse mmse restriction size disclosed information oracle performance arbitrary network topology subsequently show exchange local estimates sufficient achieve oracle performance certain network topologies inspecting network structures propose recursive algorithms achieving oracle performance disclosure local estimates practical implementations also provide approaches reduce complexity algorithms time windowing observations finally numerical examples demonstrate superior performance introduced algorithms finite horizon mse sense due optimal estimation elsevier inc rights reserved
background linking firefighter injury reporting general motion patterns may provide insight potential injury mechanisms development prevention strategies objective characterize injuries sustained members large canadian metropolitan fire department year span methods data taken injury reports filed career firefighters injuries described job duty type body part affected general motion pattern employed time injury lifting results injuries reported categorized sprains strains musculoskeletal disorders msds frequent affected back categorized job duty msds sustained working fire station physical training related activities attributed fireground operations furthermore associated job duty could differentiate types injuries sustained back injuries occurred primarily lifting knee injuries stepping shoulder injuries pushing pulling related activities conclusions firefighter injuries fireground problem injury causation may better understood linking injury location type motion patterns rather job duties information could assist developing general prevention strategies fire service
paper addresses question whether relatively high status women pre colonial south east asia still evident among malay women twentieth century peninsular malaysia compared patterns east south asia malay family structure follow typical patriarchal patterns patrilineal descent patrilocal residence newly married couples preference male children empirical research including ethnographic studies gender roles rural villages demographic surveys shows women often economically active agricultural production trade men occasionally participated domestic roles findings mean complete absence patriarchy evidence continuity aspects historical pattern relative gender equality future gender equality malaysia may depend much understanding past well drawing lessons abroad
pituitary stalk interruption syndrome psis consisting triad ectopic posterior pituitary epp thin absent pituitary stalk anterior pituitary hypoplasia rare pituitary malformation variable degrees pituitary insufficiency isolated growth hormone deficiency tsh gonadotropin acth deficiency may occur time normo hyper hypoprolactinemia central diabetes insipidus cases also extrapituitary malformations described cases genetic defects identified cases mri findings considered predictive endocrine phenotype aim describe two cases psis without central diabetes insipidus anosmia extrapituitary malformations except minor head dysmorphic features first case referred age years short stature sds height bone age years diagnosed severe deficiency developed central hypothyroidism hypoprolactinemia five years follow second case year old male birth asphyxia cryptorchidism poor growth childhood adolescence height sds absent puberty normal adult height sds bone age years active growth plates tsh acth deficiency low normal prl levels increasing medical awareness psis clinical endocrine heterogeneity may help early accurate diagnosis corroboration neuroimaging endocrine data improve knowledge understanding create premises molecular diagnosis genetic counseling better patients management
measure switching probability distributions first second switches stacks bisrcacuo delta intrinsic josephson junctions measure switching probability distributions design current source introduced microcontroller resolution accuracy sufficient measuring switching probability distributions intrinsic josephson junctions first switch crossover temperatures thermally activated escape macroscopic quantum tunneling range crossover temperatures second switch approximately samples critical densities respectively analyze critical current density dependence crossover temperature second switch crossover temperature decreases increasing critical current density anticorrelation explained neither single junction model heating effect anticorrelation peculiar phenomenon observed second switch consider anticorrelation attributed capacitive coupling strength capacitive coupling weaker ijjs higher critical current density charge screening length shorter due increase carrier density
paper analyzes effect operational amplifier opamp input offset continuous time delta sigma delta sigma modulators current mode feedback digital analog converters dac analysis shows input offset leads either increased harmonics increased noise floor modulator depending whether dac shuffling scheme data weighted averaging dwa applied analysis mathematical derivation given verified transistor level simulations input offset cancellation scheme proposed demonstrated simulation results
deep brain stimulation dbs become standard therapy parkinson disease also currently investigation neurological psychiatric disorders although many scientific clinical ethical issues still unresolved dbs delivered subthalamic nucleus stn improved quality life several thousands patients mechanisms underlying stn dbs debated extensively several reviews less investigated biochemical consequences still scrutiny crucial partially understood instance complex interplays occurring stn dbs levodopa centred therapy post surgery follow main goal review address question whether improved motor control based stn dbs therapy also achieved additional modulation neurotransmitters noradrenaline serotonin critical issue understand acute dbs mediated effects also chronic changes involving cyclic nucleotides capable modulating circuit plasticity present article discuss neurochemical changes promoted stn dbs document main results obtained microdialysis studies furthermore also examine preliminary achievements voltammetry applied humans discuss new hypothetical investigational routes taking account novel players glia subcortical regions pedunculopontine ppn area understanding specific changes brain chemistry promoted stn dbs would disseminate utilisation stage disease avoiding irreversible lesioning approach elsevier ltd rights reserved
plays critical role several processes involved skeletal cardiac muscle contraction one key step cardiac excitation contraction coupling activation cardiac ryanodine receptor ryr cytosolic elevations although process critical skeletal coupling activation inhibition skeletal ryanodine receptor ryr seem important overall muscle function ryr ryr channels fall within large category binding proteins harbour highly selective binding sites receive translate various signals specific functional responses however little known precise localization sites within cytosolic assembly ryr isoforms although several experimental lines evidence highlighted hand nature hand proteins share common helix loop helix structural motif highly conserved residues involved coordination first step predicting hand positive regions compare primary protein structure hand motif employing available bioinformatics tools although simple method narrows search regions provide solid evidence regarding regions bind ryr isoforms review seek highlight key findings experimental approaches strengthen future efforts identify cytosolic binding sites responsible activation inhibition ryr channel much less work conducted ryr channel
background buprenorphine proven effective treating opioid use disorder however high cost buprenorphine limited prescribing capacity may restrict access effective medication assisted treatment opioid use disorder objective examine whether medicaid expansion physician prescribing capacity may impacted buprenorphine utilization covered medicaid research design used quasi experimental difference indifferences design compare pre post changes medicaid covered buprenorphine prescriptions buprenorphine spending states implemented medicaid expansions affordable care act subjects medicaid enrollees expansion states nonexpansion late expansion states measures quarterly medicaid prescriptions buprenorphine spending buprenorphine centers medicare medicaid services medicaid drug utilization files results state implementation medicaid expansions associated increase medicaid covered buprenorphine prescriptions increase buprenorphine spending physician prescribing capacity also associated increased buprenorphine utilization conclusions medicaid expansion potential reduce financial barriers buprenorphine utilization improve access medication assisted treatment opioid use disorder active physician participation provision buprenorphine needed ensuring medicaid expansion achieves full potential improving treatment access
studied verified experimentally enhancement anticipation time cascading chua circuits experiments carried one dimensional array chua circuits coupled unidirectionally one acts master next one observed anticipation time increases increase array size moreover numerical simulations array eighty chua circuits verify experimental observations elsevier rights reserved
catalytic oxidation ambient temperature drawn wide attention new promising method air cleaning converting hazardous materials non hazardous ones however limited information available regarding catalytic filter performance characteristics real operating conditions especially service efficiency byproducts also practical scale method evidence filter performance evaluation currently available scale laboratory results real application conditions limitations knowledge gaps prevent building owners designers adopting new promising technique commercial industrial applications present study conducted experiments small scale full scale chamber tests challenged developed catalytic filter realistic conditions formaldehyde selected approach demonstration due indoor ubiquitousness criticality human health even low levels results showed competition level reaction sites filter media crucial role performance formaldehyde abatement high initial competing pollutants typical stable level depending coexistence pollutants moisture air employment type filter might generate byproducts opposite previous literature reports small scale column tests represented good indication large scale filter performance practical screening method elsevier rights reserved
purpose study examine whether early late start typology criminal behaviour major mental disorder generalized different populations evaluated date replicable two different countries dutch forensic sample sample consisted reports court early start offenders late start offenders canadian civil psychiatric sample sample consisted file information collected involuntarily hospitalized civil psychiatric patients early start group late start group samples early late starters compared different domains results showed general early starters higher risk problems different domains also differences early late start typology dutch canadian samples results partially support early late starter typology within two different samples study showed early starters typically higher risk problems different domains highlights importance different risk management treatment strategies early start late start group
explosive growth digital data communications synergistic operating networks cloud computing service hyperconnected manufacturing collaboration systems face challenges extracting processing analyzing data multiple distributed web sources although semantic web technologies provide solution web data interoperability storing semantic web standard relational databases processing analyzing web accessible heterogeneous digital data web data storage retrieval via predefined schema relational sql databases become increasingly inefficient advent big data response problem hadoop ecosystem system adopted reduce complexity moving data big data cloud platform paper proposes novel approach set hadoop tools information integration interoperability across hyperconnected manufacturing collaboration systems hadoop approach data extracted web sources loaded set nosql hadoop database hbase tables transformed integrated desired format model hive schema read case study conducted illustrate hadoop extract load transform elt approach syntax semantics web data integration could adopted across global smartphone value chain published elsevier
aimit reported many people dementia require hospitalizations objective present study determine predictive factors hospitalizations people dementia methodsa total individuals dementia living veterans home southern taiwan consecutively enrolled prospective follow hospitalization events recorded resultsthe mean age residents dementia years mean follow time population years among individuals suffered malnutrition risk malnutrition minimal nutritional assessment short form score individuals body mass index individuals previously fallen overall residents hospitalized follow period individuals previous falls significantly increased risk hospitalization odds ratio furthermore three factors significantly associated risk fall including handgrip strength malnutrition mini mental state examination score conclusionsthe results present study showed hospitalization frequent event residents dementia living long term care facility major predictor hospital admission history previous fall screening dementia history injurious falls associated risk factors falling could help identify risk hospitalization thus necessitating comprehensive intervention reduce hospitalization geriatr gerontol int suppl
animal hairs existing broadly nature found effectively responsive stimuli heat water sequence shape deformation recovery namely coupled shape memory function csmf paper ability thermo water sensitive csmf first time investigated animal hairs structural molecular networks net points switches therefrom identified experimentally animal hair manifested high ability shape fixation thermal processing good shape recovery water stimulus characterizations two stimuli heating hydration performed systematically hair deformation recovery viscoelasticity chemical components crystalline phase key bonds inamorphous area variations related chemical components molecular networks also explored hybrid structural network model thereafter proposed interpret thermo water sensitive csmf hair study two sequential stimuli csmf original inspired explore complex functions smart natural materials expected make much smarter synthetic polymers
students karlsruhe university initiate plan develop engineering projects worldwide sole responsibility summer built suspension bridge small village sri lankan jungle report going show emphasize challenges come along conducting project next project funding needs discussed clearly well fact whole team needs confronted possible cultural differences characteristics considering construction suspension bridge needs kept mind material needs extremely solid due sri lankan humid climate construction bridge supposed planned simple possible university students villagers familiar working construction site going build bridge addition logistical reasons possible bring move big construction machines sri lankan jungle therefore necessary throw acquired knowledge overboard come creative concepts ideas suspension bridge built finished within four months communication problems tropical storms well difficulties accurate project planning purchasing day construction site like looking back reliable team staying power close cooperation villagers indispensable completing tremendous project successfully
increasing use aluminum shape castings structural applications automotive aerospace industries assurance cast product integrity performance become critical design manufacturing paper latest understanding relationship casting quality mechanical properties aluminum castings summarized newly developed technologies alloy design melting melt treatment casting heat treatment processes aluminum casting reviewed mechanical properties aluminum castings strongly depend upon microstructure constituents particularly cast defect population distribution produce quality castings quantifiable properties key control multi scale defects microstructure casting robust design development high integrity aluminum castings integrated computational materials engineering icme approach also discussed effective way optimize processes achieve desirable mechanical properties development exploitation robust accurate multi scale computational models
objective arterial concentration carboxyhemoglobin subjects inflammatory pulmonary disease higher healthy individuals retrospectively analyzed relationship concentration established markers disease severity subjects interstitial lung disease ild methods concentration measured subjects newly diagnosed untreated ild relationships concentration serum biomarker levels lung function highresolution hrct findings uptake gallium scintigraphy evaluated results eighty one non smoking subjects studied mean age years among subjects stable idiopathic pulmonary fibrosis ipf acute exacerbation ipf stable non ipf exacerbation non ipf concentrations subjects concentration positively correlated serum levels surfactant protein inflammation index calculated hrct negatively correlated partial pressure oxygen arterial blood predicted diffusion capacity carbon monoxide concentrations subjects negative heart sign scintigraphy higher subjects without negative heart sign conclusion levels subjects ild increased particularly exacerbation correlated parameters reflect pulmonary inflammation
use unmanned aerial vehicles uavs growing significantly many varied purposes mission outdoor uav guided following planned path using gps signals however gps capability may become defective environment may gps denied additional safety aid therefore required automatic landing phase independent gps data uavs equipped machine vision systems together onboard analysis used safe automatic landing contributes greatly overall success autonomous flight paper proposes automatic expert system based image segmentation procedures assists safe landing recognition relative orientation uav platform proposed expert system exploits human experience incorporated machine vision system mapped proposed image processing modules result improved reliability capability could incorporated uav especially robust rotary wing uavs clearly desirable fail safe capability elsevier ltd rights reserved
surface meshes recently attracted great interest since frequently used many computer graphics applications meshes often generated isosurfacing representations also scanning devices unfortunately meshes dense contain many redundant vertices irregular sampling make meshes unable support multiple applications storage display compression transmission solve problems reduce complexity mesh quality connectivity regularity must improved improvement called remeshing hand many researches techniques done exploit mesh local planarity optimize geometric representation paper presents novel multiresolution approach remeshing based planar proxies
present new method computation hydraulic axial thrust francis hydro turbine approach combines computation axial thrust crown band blade using numerical simulation calculation pressure distribution outside crown band based theory fluid mechanics axial thrusts calculated different flow conditions various suction head flow rate calculated results consistent experimental test prototype hydro turbine combination proven effective way assess magnitude hydraulic axial thrust hydro turbine also suction head turbine shown significant influence hydraulic axial thrust
paper investigate modified korteweg vries zakharov kuznetsov hirota equations obtain exact travelling wave solutions using jacobi elliptic function expansion method together symbolic computation system mathematica limit cases obtained periodic solutions degenerate corresponding solitary wave solutions types solutions
streptozotocin stz treatment common model inducing diabetes rodent models induces thermal hyperalgesia neuronal toxicity independently hyperglycemia oxidizing activating trpa trpv following treatment stz immune cells found depleted sciatic nerve drg mice prior hyperglycemia macrophages also lost drg kappa activation increased macrophages immune cells significantly reduced drg three weeks post treatment loss pns resident macrophages response stz mediated toxicity may affect regenerative capacity nerve response injury caused diabetes elsevier rights reserved
paper presents novel distributed classifier convergence allows detect convergence divergence distributed converging algorithm since classifier supposed primarily applied wireless sensor networks proposal makes provision character networks classifier based mechanism comparison forward finite differences two consequent iterations convergence divergence classifiable terms changes inner states particular node therefore message redundancy required proper functionality
background second generations antipsychotics sga frequently used maintenance treatment bipolar disorder systematically reviewed efficacy long term effects treatment sga regardless treatment strategy sga administered either monotherapy adjunctive therapy comparison placebo lithium valproate primary outcomes relapses mood episode recurrence discontinuation method clinical studies identified database searching pubmed embase psychinfo cochrane library critically appraised based cochrane handbook full data extraction raw data performed analyzed meta analyses level evidence graded using grade randomized controlled studies rct observational studies included minimum follow months comparators used restricted placebo lithium valproate anti epileptic drugs results identified rcts sga bipolar disorder follow time months years one observational study reporting long term effects years total patients included randomized trials long term rcts beyond years follow identified rcts except one included patients bipolar disorder type rcts except two included patients pre stabilized drug investigation prior randomization enrichment design sga adjunctive therapy lithium valproate meta analyses showed treatment either aripiprazole quetiapine ziprasidone reduced overall risk relapses patients responded stabilization phase adjunctive therapy quetiapine drug reduced manic depressive episodes sga monotherapy quetiapine shown better lithium valproate manic depressive relapses patients stabilized quetiapine acute phase monotherapy olanzapine quetiapine risperidone shown superior placebo reducing overall risk relapses limitations considerable limitations evidence base maintenance treatment sga bipolar disorder studies used stabilized patients enrichment design selection bias considerable dropout levels attrition bias variable degree reporting bias long term rct data efficacy available beyond years almost studies bipolar disorder type patients despite limitations elucidate quantitative findings meta analyses conducted randomized trials published topic
background prenatal detection congenital malformations gives opportunity positively influence prenatal postnatal management survival morbidity well allow parental choice psychological preparation objective examine available evidence regarding impact detection underdetection fetal anomalies well fetal therapy neonatal outcome parental psychological wellness neonatal care organization methods literature search pubmed results conclusions impact prenatal diagnosis neonatal survival morbidity dependent upon type severity anomalies inasmuch upon evaluation criteria chosen discuss various pitfalls design trials explaining studies targeting selected anomalies shown improved outcomes associated prenatal diagnosis congenital malformations fetal therapy applies mainly conditions lethal either utero birth untreated birth rarely evaluated highest level evidence may explained poor acceptability randomization prenatal intervention expectancy delivery
predicted members chinese groups would tend express personality judgments establish commonalities among members whereas members american groups would tend express judgments affirm members differ groups five acquaintances groups one university groups three chinese universities rate traits subjected round robin data social relations model social accuracy model analyses hypothesized chinese likely portray peers similar indicated greater perceived self similarity less variance target ratings conversely americans likely express shared understanding distinguished group member others indicated greater distinctive agreement target variance consensus collectivistic values mediated effects country perceived similarity individualistic values mediated effects country consensus perceived similarity
construction management processes focused technical aspects minimal consideration social factors among trust prominent impact project efficiency success according construction industry institute study among factors impacted low trust efficiency administrative costs trust defined hard edged economic driver affects speed cost two three pillars project management preliminary data literature provides evidence trust ignored construction management address gap paper identifies trust impact construction bidding processes perceived professionals adopted research methodology utilizes survey instrument identify important parameters upon selection processes depend characterize industry professionals view trust effects process results indicate trust even explicitly stated plays major role processes furthermore direct correlation trust level contractor subcontractor selection among project delivery methods results emphasize impact trust bidding strategies provide decision makers better understanding actions
paper presents effective technique synchronization secure communication particular adaptive sliding mode observer developed practically implemented one component state vector transmitter satisfies observability matching condition sent receiver via public channel sliding mode observer observer able estimate state vector transmitter reconstruct unknown information hidden transmitted inclusion encryption finally chaotic secure communication system simulated matlab practically implemented electrical circuits multisim software ultiboard software
objective study aims compare perioperative oncological outcomes laparoscopic open liver resection colorectal liver metastases elderly background laparoscopic liver resection associated less morbidity similar oncological outcomes open liver resection colorectal liver metastases crlms reported benefits continue observed elderly patients however previous studies patients years considered single homogenous population raising questions regarding true impact laparoscopic approach diverse group elderly patients method prospectively maintained databases patients undergoing liver resection crlm tertiary liver centers included years old selected study cohort divided subgroups based age comparative analysis performed implementation propensity score matching main cohorts laparoscopic open groups also study subgroups results total patients included study propensity score matching patients comparable main groups lower blood loss less overall morbidity shorter high dependency unit days total hospital stay days observed laparoscopic liver resection comparable rates resection median recurrence free survival months overall survival months observed advantages seen laparoscopic approach reproduced year old subgroup however gradual loss advantages increasing age conclusions patients years age laparoscopic liver resection colorectal liver metastases offers significant lower morbidity shorter hospital stay comparable oncological outcomes compared open liver resection however benefits laparoscopic approach appear fade increasing age statistically significant benefits octogenarians except lower high dependency unit stay
adolescent poverty associated increased antisocial decreased prosocial behaviors attenuating negative effects relevant individual societal well research exploring youth poverty escape antisocial behaviors move toward prosocial behaviors limited primarily risk factors strengths perspective sought understand potential resiliency factor purpose life could protect youngsters deleterious effects poverty conceptualized purpose life central future oriented goal organizing framework provides adolescents reasons resist antisocial behavior engage prosocial behaviors moderation analyses purpose life mitigated effects poverty antisocial behavior disobedience bullying failed boost prosocial traits behaviors youth poverty emphasize importance developing sense purpose economically disadvantaged youth bettering lives communities
paper presents considerations virtual manufacturing way virtual manufacturing environments used teaching learning learning aspects information transfer acquisition using images outlined paper presents structure learning module manufacturing engineering achieved authors points relevant examples finally way users manipulate virtual manufacturing scene via internet shown
background chronic constipation common severe gastrointestinal complaint parkinson disease pathogenesis remains poorly understood study evaluated functionally distinct submucosal neurons relation colonic motility anorectal function patients constipation controls methods twenty nine rome iii defined patients enrolled twenty asymptomatic age sex matched subjects served controls colonic transit time measurement conventional anorectal manometry evaluated patients colonoscopy performed three groups colonic submucosal whole mounts controls processed immunohistochemistry antibodies vasoactive intestinal polypeptide vip peripheral choline acetyltransferase markers functionally distinct submucosal neurons mrna expression vip receptors also assessed key results four subgroups patients identified delayed colonic transit plus altered anorectal manometry delayed colonic transit altered manometric pattern transit manometric impairment differences number neurons ganglion controls reduced number submucosal neurons containing vip immunoreactivity found controls vip vipr vipr mrna expression significantly reduced controls conclusions inferences colonic motor rectal sensory functions impaired patients abnormalities associated decreased vip expression submucosal neurons sensory motor abnormalities neurally mediated motor secretory mechanisms likely contribute pathophysiology
current study presents methodology analyze first impressions basis minimal motion information order test applicability approach brief silent video clips speakers presented independent observers know speakers rated measures big five personality traits body movements speakers captured placing landmarks speakers forehead one shoulder hands analysis revealed observers ascribe extraversion variations speakers overall activity emotional stability movements relative velocity variation motion direction openness although ratings openness conscientiousness related biographical data speakers measures career progress measures body motion failed provide similar results conclusion analysis motion behavior might done basis small set landmarks seem capture important parts relevant nonverbal information author published elsevier inc rights reserved
chronic cocaine use associated abnormalities brain structure function within interactions regions previous studies limited interrogating structure function independently detected neural differences applied independent samples assess clinical relevance results investigated consequences structural differences resting state functional connectivity cocaine addiction tested whether resting state functional connectivity identified circuits predict relapse independent cohort subjects included non treatment seeking cocaine users ntscus healthy control subjects independent treatment completed cohort cocaine dependent individuals scanned end day residential treatment programme differences cortical thickness related resting state functional connectivity ntscus healthy control subjects identified survival analysis applying cortical thickness identified regions resting state functional connectivity identified circuits clinical characteristics treatment cohort used predict relapse lower cortical thickness bilateral insula higher thickness bilateral temporal pole found ntscus versus healthy control subjects whole brain resting state functional connectivity analyses four different anatomical regions seeds revealed eight weaker circuits including within salience network insula seeds temporal pole elements default mode network ntscus applying circuits clinical characteristics independent cocaine dependent treatment cohort functional connectivity right temporal pole medial prefrontal cortex combined years education predicted relapse status days accuracy deficits salience network suggest impaired ability process physiologically salient events abnormalities temporal pole medial prefrontal cortex circuit might speak social emotional functional alterations cocaine addiction involvement temporal pole medial prefrontal cortex circuit model highly predictive relapse highlights importance social emotional functions cocaine dependence provides potential underlying neural target therapeutic interventions identifying high risk relapse
backpressure scheduling algorithm multihop wireless networks known throughput optimal requires node maintain per destination queues recently clever generalization processor sharing proposed also throughput optimal uses per link queues propose another algorithm called queue proportional rate allocation qpra also uses per link queues allocates service rates links proportion queue lengths employs serve random order queueing discipline within link fluid limit techniques using novel lyapunov function show qpra algorithm achieves maximum throughput demonstrate advantage qpra showing called primary interference model able develop low complexity scheduling scheme approximates qpra achieves constant fraction maximum throughput region independent network size
objectives given sensitivity individuals mood disorders circadian disruption transmeridian travel would likely high risk endeavour leading onset relapses mood systematic review undertaken identify evidence impact transmeridian travel people mood disorders methods databases search included following cinahl medline psycinfo manual searching using keywords jetlag transmeridian travel circadian rhythm disruption mood disorder bipolar major depression seasonal affective disorder depression mania hypomania results three studies identified related transmeridian travel jetlag people mood disorders suggestion transmeridian travel appear precipitate mood episodes increased rate episodes depression westward compared increased rate manic hypomanic episodes eastward travel individuals previous history mood disorder appear vulnerable adherence medication compromised conclusion given limited evidence transmeridian travel precipitates mood episodes poses difficulties identifying suitable ways mitigate effects transmeridian travel mood disorders however absence mood specific guidelines guidance given based current understanding relevance circadian disruption jetlag mood disorders research required identify focused strategies mitigate impact transmeridian travel individuals mood disorders
aim present study provide descriptive dietary patterns home living older adults examine association sociodemographic diet related variables health psychological factors dietary patterns analyzed using separately cluster analysis men age range women age range older adults aged years cluster analyses showed four distinct dietary profiles gender older men four distinct dietary clusters associated differences sociodemographic diet related variables cognitive function health psychological factors likewise older women four distinct dietary clusters associated differences sociodemographic diet related variables however older women results showed cluster high fish fruit vegetable associated better cognitive function better self rated health depressive symptoms whereas cluster moderate ready meals associated cognitive decline slight depression poor perceived health results emphasize interest take consideration health psychological factors associated dietary patterns better target vulnerability individuals enable effective prevention elsevier rights reserved
offshore software development outsourcing osdo global software engineering paradigm developing high quality software low cost low wage countries client organisation contracts part software development activities vendor organisation vendor organisation provides agreed software development work return remuneration objective research identify critical challenges faced vendor organisations management execution osdo contract analyse identified challenges based variables time year organisational size authors used systematic literature review identification challenges osdo contract identified challenges faced vendors osdo contract amongst nine challenges marked critical challenges analysed identified challenges based different variables organisational size time correlation analysis vendor organisations concentrate addressing identified critical challenges lack project management poor monitoring system lack outsourcing relationship management cultural linguistic issues non competitive price intellectual property rights ipr regulatory issues failure manage end user expectation lack negotiation strategies unforeseen contingencies successful outcome osdo contract
background aimed explore natural history irritable bowel syndrome ibs denmark years studying development ibs symptoms associated factors methods cohort study carried using web panel representative danish general population years survey including questionnaire based rome iii criteria ibs conducted january january march key results prevalence ibs incidence three times higher persons unspecific gastrointestinal symptoms compared asymptomatic persons respondents ibs symptoms also reported symptoms ibs significantly compared respondents ibs symptoms reporting asymptomatic unspecific symptoms respectively diagnosed ibs predicted fulfilling criteria ibs years later fulfilling criteria ibs year also led high risk ibs symptoms years later asymptomatic persons persons unspecific symptoms baseline conclusions inferences vast majority persons fulfilling criteria ibs report symptoms one years fulfilling ibs criteria year led high risk reporting ibs symptoms years general population ibs diagnosis predicts persistently fulfilling rome iii criteria ibs years later
purpose study aims examine library programming active older third age adults give suggestions future improvements addition covering research specific library programming adults limited review also survey literature lifelong learning population design methodology approach paper includes literature review library programming geared specifically active older adults survey literature lifelong learning third agers findings demographics show older adults growing population usa worldwide many baby boomers already entered soon entering third age libraries providing specific programming support older lifelong learners usa baby boomers highest net worth generation important fundraising source research indicates older adults participate lifelong learning activities attend library programs interest topics interest include hobbies leisure pursuits humanities social international issues religion philosophy arts technology nutrition health stress management practical implications libraries missing prime opportunity expand services develop library advocates fundraise ignoring growing population active older adults suggestions given public academic libraries take advantage opportunities social implications older adults rapidly growing population providing library programming group benefits older adults libraries originality value known previous comprehensive literature reviews library programming older adults offering specific programming population benefits older adults libraries communities
present new scheme implementing passive quantum key distribution thermal distributed parametric conversion source scheme one intensity decoy state employed achieve precise estimation single photon pulse contribution utilizing built decoy states moreover compare new scheme practical methods standard three intensity decoy state protocol using either weak coherent states parametric conversion source numerical simulations demonstrate new scheme drastically improve secure transmission distance key generation rate
model developed simulate electromigration degradation interconnect segment two dimensions using finite differences model deployed parallel computer statistically assess lifetimes simulation takes account diffusion paths electromigration mass transport along grain boundaries capping layer microstructure generated monte carlo algorithm using modified potts model diffusivities along grain boundaries capping layers applied multiples base diffusivity statistically scattered simulation results correlate well electromigration tests elsevier rights reserved
cetuximab monoclonal antibody part treatment metastatic colorectal cancer common side effect cetuximab skin rash similar distribution acne vulgaris overlapping pathophysiological mechanisms aim current study determine whether acne vulgaris adolescence aina predictive cetuximab related rash better understand pathogenesis side effect explore potential preventive actions july june patients metastatic colorectal cancer planned treatment cetuximab enrolled study initiating treatment patients completed questionnaire evaluating endocrine disorders chronic diseases smoking chronic medications allergies dermatologic history aina severity patients followed months data collected participants women men twenty three patients experienced cetuximab associated skin reaction nine patients history aina seven developed cetuximab associated skin reaction three five patients used proton pump inhibitors ppis developed severe grades skin toxicity versus patients ppis degree skin toxicity correlated median time tumor progression months patients grades compared months grades skin toxicity confidence interval significant correlation found aina cetuximab associated skin reactions correlation ppi treatment severe skin toxicity related cetuximab examined
objectives determine enhance integration minority students health education thereby improve intercultural communication skills cultural sensitivity sample health teacher students norway methods group work intervention period six months afterwards followed action research approach observed health teachers training first year oslo akershus university college classroom interactions data qualitative comprised student self reports survey results along observations three teachers authors study data analyzed using constant comparative approach opinion categorization open coding procedure separate analyses performed observations minority students majority students teachers results ethnic majority minority students experienced increase intercultural knowledge problem solving ability experience early intervention first academic year tertiary education students reacted favorably intervention noted class assessments challenges rewards overcoming cultural barriers teacher observation notes confirmed early intervention led increase interaction cross cultural engagement minority majority students compared previous years classes without intervention conclusions early classroom intervention promote intercultural engagement prevent clique formation along majority minority lines method used tailored group assignments ethnically diverse working groups beginning students tertiary academic career effective approach cultivating attitudes skills fostering intercultural awareness sensitivity
current study sought examine relative contributions encoding retrieval processes accessing contextual information absence item memory using extralist cuing procedure retrieval cues used query memory contextual information related target item never actually studied experiments participants studied category member onion variety different categories test presented unstudied category label vegetable probe memory item source information experiments member unidirectional credit card bidirectional salt pepper associates studied whereas unstudied member served test probe recall failed source information accessible items processed deeply encoding experiments strong forward associative strength retrieval cue target experiments findings suggest retrieval probe diagnostic semantically related item information reinstantiates information bound memory encoding results reactivation associated contextual information contingent upon sufficient learning item association item context information
areas china facing pressing air pollution problems measures power sector taken cope air pollution issues including reducing emission levels thermal units integrating wind solar power social welfare emission renewable integration three major concerns modern power system operations paper describes three stochastic scheduling models aiming maximizing social welfare minimizing emission maximizing renewable production multi objective scheduling model also proposed properly balances objectives wind power uncertainty dispatchable loads considered model outcomes three models compared illustrative example node case study results show model results social welfare model emissions wind spillage model results social welfare model emissions wind spillage additionally analyze optimal generation scheduling affected weights model work provides insight policy makers balance social welfare emissions renewable production elsevier ltd rights reserved
water scarcity arid semi arid regions great economic environmental social problem people living regions use technologies cistern ensure water survival given difficulties regions paper aims propose methodology estimate per capita water use different levels water shortage risk ensuring water supply conditions arid semi arid regions present case study brazilian semi arid region methodology based analysis spatial temporal risks water shortage cisterns analysis temporal risk water shortage based premise cistern without water consecutive days return periods years ascertain spatial risk per capita water use associated return periods hydrologically homogeneous regions evaluate confidence interval associated average monthly water use thus proposed methodology allows determine potential water use homogeneous region brazilian semiarid region possible identify areas local population greater restriction access water central semiarid region areas greater water availability north south semi arid variation water availability allows adapt management measures accounting ground conditions location order meet water needs local population
paper explores issues associated photonic integrated circuit pic research development overall goal initiating discussion pic technology develop eventually deployed high impact significant research development programs focused pics routing switching computer interconnects recently application domain pics diversified greatly includes analog signal processing remote sensing biological chemical sensing neural interfacing solar cells key feature pic technology growth exploitation high density fabrication packaging technology originally developed silicon industry pic foundry services emerging natural attempt ascribe moore law pic scaling analogies silicon electronic scaling however used caution pic complexity scaling may driven ability access degrees freedom offered pic based optical domain signal processing rather increasing device count specific examples pic research chip scale computer interconnects integrated micro concentrators solar cells highlighted
purposeour goal determine differences place residence visiting doctor help getting pregnant population based study methodsusing data furthering understanding cancer health survivorship adult fuchsia women study cohort study fertility outcomes reproductive aged women georgia fit models estimate association geographic type residence seeking help becoming pregnant findingsthe prevalence visiting doctor help getting pregnant ranged across geographic groups women living suburban counties likely seek medical care help getting pregnant compared women living urbanized counties adjusted prevalence ratio apr among women reported infertility difference pronounced apr women living rural counties equally likely seek fertility care compared women urbanized counties full sample among women experienced infertility conclusionswomen living urban rural counties least likely seek infertility care suggesting factors including limited physical proximity providers influencing utilization type care increased communication reproductive goals infertility care available meet goals providers women see regular care may help address barriers
study included mother infant dyads asian united states america cohorts examine whether genomic profile risk score major depressive disorder gprs mdd moderates association antenatal maternal depressive symptoms socio economic status ses fetal neurodevelopment identify candidate biological processes underlying association cohorts showed significant interaction antenatal maternal depressive symptoms infant gprs mdd right amygdala volume asian cohort also showed interaction right hippocampal volume shape thickness orbitofrontal ventromedial prefrontal cortex likewise significant interaction ses infant gprs mdd right amygdala hippocampal volumes shapes controlling interaction effect antenatal maternal depressive symptoms gprs mdd mainly shown right amygdala interaction effect ses gprs mdd mainly shown right hippocampus bioinformatic analyses suggested neurotransmitter neurotrophic signaling snap receptor complex glutamate receptor activity common biological processes underlying influence antenatal maternal depressive symptoms fetal cortico limbic development findings suggest gene environment interdependence fetal development brain regions implicated cognitive emotional function candidate biological mechanisms involve range brain region specific signaling pathways converge common processes synaptic development
food drug administration fda introduced changes labeling indications use testosterone products due possible increased risk cardiovascular events decision made based six clinical studies supported increased risk since decision additional studies published examining interplay hypogonadism risk testosterone demonstrating risk may lower originally estimated clinicians placed difficult position studies support increased mortality risk hypogonadal men also increased risk events men testosterone therapy result many clinicians selective prescribing testosterone review examine new guidelines arose may affect prescribing habits
drawing multilevel model motivation work groups functionalist perspective citizenship socially responsible behaviors developed tested multilevel model voluntary workplace green behavior explicates reasons employees voluntarily engage green behavior work sample office workers organized work groups three firms found conscientiousness moral reflectiveness associated voluntary workplace green behavior group leaders individual group members furthermore found direct relationship leader green behavior green behavior individual subordinates well indirect relationship mediated green advocacy within work groups theory findings shed new light psychological social conditions processes shape voluntary workplace green behavior organizational settings suggest implications organizations striving improve social responsibility environmental sustainability
article presents case year old female patient exacerbation pre existing tension type headache exacerbation occurred within scope infection persisted infection receded excessive diagnostic approaches went weeks finally came end diagnosis pregnancy impacts hormonal changes headaches caused pregnancy discussed well postinfection events
current research examined people form context based trait impressions impressions stronger others research drew principles attention theory kruschke order account processes underlying impression formation context according attention theory traits expressed individual target person rarely occurring context strongly associated context traits expressed commonly occurring context associated common context people form stronger impressions others behavior rare compared common contexts four experiments provide support predictions current study one first examine cognitive mechanisms perceivers form trait impressions individuals across different contexts explain impressions stronger others implications nature impression formation processes discussed elsevier inc rights reserved
multigene testing breast cancer recurrence risk became available yet many eligible patients remain untested study evaluated variation testing rates oncologist organizational factors associated variation setting without financial influences testing conducted retrospective cohort study using electronic data oncologist surveys within kaiser permanente northern california large integrated health care system analyses included test eligible patients oncologists practice groups receipt multigene testing evaluated generalized linear mixed models overall eligible patients multigene testing rates varied widely among practice groups ranging case mix adjustment difference among practices greater variation associated patient characteristics including comorbidities race ethnicity similar associated tumor size practice group oncologist factors statistically significant contributors variation testing adjusting patient factors patients likely tested female oncologist aor practice whose chief high testing rate aor per increase percent tested oncologist leadership practices play key role variation genomic test use cancer recurrence risk even healthcare system without financial barriers testing could leverage point implementing desired practice changes new genomic advances
aes algorithm rijndael algorithm network security algorithm commonly used types wired wireless digital communication networks secure transmission data two end users especially public network paper presents hardware implementation aes rijndael encryption decryption algorithm using xilinx virtex fpga hardware design approach entirely based pre calculated look tables luts results less complex architecture thereby providing high throughput low latency basically three different formats aes aes aes aes encryption decryption blocks three formats efficiently designed using verilog hdl synthesized virtex xcvxt chip target device help xilinx ise design suite tool synthesis tool set optimize speed area power power analysis made using xilinx xpower analyzer pre calculated luts used implementation algorithmic functions namely box inverse box transformations also galois field multiplications involved mix columns inverse mix columns transformations proposed architecture found good efficiency terms latency throughput speed delay area power
vitamin binding protein dbp gene encodes alpha globulin transports vitamin metabolites serum given role vitamin onset disease progression analyzed frequencies three polymorphisms within dbp gene italian multiple sclerosis patients healthy controls none polymorphisms showed association onset progression results suggest dbp involved pathogenesis italians elsevier rights reserved
background extreme health workforce shortage eastern central southern africa shortage eye care workers impedes effective implementation prevention blindness programs world health organization identified education partnership leadership financing policy intertwined interventions critical resolving crisis long term case presentation vision link college ophthalmology eastern central southern africa royal college ophthalmologists united kingdom aims increase quantity quality eye care training east central southern africa focus five strategic areas fellowship examination ophthalmologists training trainers curriculum development residents ophthalmology ophthalmic clinical officers continuous professional development cpd mentoring program young ophthalmologists study examined education partnership linked improve eye care evaluation north south link based targets established frameworks guide north south links methods exploratory qualitative case study design used twenty nine link representatives recruited purposive sampling snowballing face face interviews conducted using semi structured interview schedule incorporated components successful link existing framework documents pertaining link also examined thematic analysis used data analysis results findings revealed perception contribution link eye care region generally positive process indicators showed targets three strategic objectives link achieved framework based evaluation also showed link successful mutual learning development friendships commonly identified success factors inadequate awareness link college members key challenge conclusion study concludes link active evolving achieved targets developments directed influence health system strengthening eastern central southern africa strategically study recommends expansion scope collaboration involve multiple health system building blocks
cyber physical embedded systems cpess distributed embedded systems integrated various actuators sensors comes issue cpes security significant problem security embedded sensor networks esns continuous growth esns security transferring data sensors destinations become important research area due limitations power storage processing capabilities existing security mechanisms wired wireless networks apply directly esns meanwhile esns likely attacked different kinds attacks industrial scenarios therefore need develop new techniques modify current security mechanisms overcome problems article focus intrusion detection techniques propose new attack defense game model detect malicious nodes using repeated game approach direct consequence game model attackers defenders make different strategies achieve optimal payoffs importantly error detection missing detection taken consideration intrusion detection systems idss game tree model introduced solve problem addition analyze prove existence pure nash equilibrium mixed nash equilibrium simulations show proposed model reduce energy consumption compared existing monitor model improve detection rate compared existing cluster head monitor model
drawing strategies widely used powerful tool promoting students learning problem solving article report results inferential mediation analysis applied investigate roles strategic knowledge drawing accuracy different types drawings play mathematical modelling performance sixty one students asked create drawing situation described task situational drawing drawing mathematical model described task mathematical drawing solving modelling problems path analysis showed strategic knowledge drawing positively related students modelling performance relation mediated type accuracy drawings generated accuracy situational drawing related indirectly performance accuracy mathematical drawings however strongly related students performance complemented quantitative approach qualitative depth analysis students drawings order explain relations found study implications teaching practices future research discussed
work citrate acetate buffers investigated neutralizers chitosan salts order provide biocompatible stable films choose appropriate film composition study neutralized chitosan citrate acetate films without plasticizer glycerol prepared characterized thickness moisture content degree swelling total soluble matter acid medium simultaneous thermal analysis differential scanning calorimetry chitosan films neutralized citrate buffer showed greater physical integrity resulted greater thicknesses lower moisture absorbance lower tendency solubility acid medium better swelling capacities according thermal analyses films higher interaction water considered important feature cosmetic application since composition prepared citrate buffer without glycerol considered present better physical integrity applied investigate hyaluronic acid release skin model skins treated films without hyaluronic acid show stratum corneum desquamation hydration within min results suggest neutralized chitosan citrate film prepared without glycerol promotes cosmetic effect skin exfoliation presence absence hyaluronic acid elsevier rights reserved
network security rapidly developing attack methods network worms one widely used attack methods able propagate quickly active defense approach network worms honeynet technique long limited closed architecture traditional network devices paper propose closed loop defense system worms based software defined networking sdn technology called worm hunter flexibility sdn network building introduced structure network infrastructures worm hunter using well designed flow tables worm hunter able easily deploy different honeynet systems different network structures dynamically anomalous traffic detected analyzer worm hunter redirected honeynet safely analyzed throughout process attackers aware caught attack behavior recorded system analysis finally verify system via experiments experiments show worm hunter able build multiple honeynet systems one physical platform meanwhile honeynet systems topology operate without interference
background severe eosinophilic asthma patients risk exacerbations associated substantial costs mepolizumab lowers eosinophil levels reduces exacerbation risk severe eosinophilic asthma evaluated asthma related exacerbation costs mepolizumab treated patients versus placebo methods within trial economic analysis mepolizumab adjunctive therapy patients severe asthma mensa trial objectives quantify incremental medical costs asthma related exacerbation asthma related exacerbation emergency department visit hospitalization costs asthma related total healthcare resource utilization results mean medical costs asthma related exacerbations months mepolizumab intravenous mepolizumab subcutaneous placebo groups respectively mean medical costs emergency department visits hospitalizations due asthma related exacerbations mepolizumab mepolizumab placebo groups asthma related healthcare resource utilization services lower mepolizumab groups versus placebo conclusions adding mepolizumab standard care treatment severe eosinophilic asthma lowered asthma exacerbation related medical costs healthcare resource utilization although cost savings ranged per patient differences statistically significant
present parallel interacting stochastic approximation annealing pisaa algorithm stochastic simulation procedure global optimisation extends improves stochastic approximation annealing saa using population monte carlo ideas efficiency standard saa algorithm crucially depends self adjusting mechanism presents stability issues high dimensional rugged optimisation problems proposed algorithm involves simulating population saa chains interact manner significantly improves stability self adjusting mechanism search global optimum sampling space well inherits saa desired convergence properties square root cooling schedule used implemented parallel computing environments order mitigate computational overhead result pisaa address complex optimisation problems would difficult saa satisfactory address demonstrate good performance proposed algorithm challenging applications including bayesian network learning protein folding numerical comparisons suggest pisaa outperforms simulated annealing stochastic approximation annealing annealing evolutionary stochastic approximation monte carlo
article explores relationship racial prejudice towards blacks black white self employment rate gap provides first direct empirical evidence racial prejudice negatively impacts black self employment particularly high start cost industries perform analysis construct measure prejudicial attitudes using responses general social survey estimate relationship self employment index using american community survey find amount prejudice equal difference least prejudiced census divisions increases black white self employment rate gap high start cost industries depending upon whether parental self employment controlled represents entire impact racial prejudice black white selfemployment rate gap additionally racial prejudice widens black white self employment income gap full specification dependent upon income measured evidence indicates racial prejudice causing blacks difficulty financing businesses results presented robust various modelling data assumptions
objective warfarin widely used stroke prevention patients nonvalvular atrial fibrillation nvaf compared rates stroke major bleeding nvaf patients high stroke risk low bleeding risk profile warfarin treated warfarin untreated periods method insurance claims six commercial medicaid medicare databases analyzed nvaf patients treated warfarin chads cha vasc score atria score baseline identified incidence rate ratios irrs stroke major bleeding calculated versus episodes person time well first days versus beyond days episodes results among patients anticoagulant prophylaxis warfarin significantly reduced stroke risk irrs ranging increased major bleeding risk irrs ranging stroke major bleeding rates higher first days beyond conclusion nvaf patients high risk stroke low risk bleeding data confirm effectiveness anticoagulation stroke prevention decrease stroke risk anticoagulation may outweigh risk major bleeding events particularly among elderly patients potential risks warfarin initiation warrant attention especially among patients stop start therapy repeatedly
monitoring electrical network important challenging task phasor measurement units measurement devices used state estimation network paper consider pmu placement problem without conventional measurements zero injection nodes full observability network propose two new approaches model problem take account propagation rule based ohm kirchoff law natural binary linear programming description models iterative observability process remove iteration reformulating fixed point conditions bilevel program reformulate single level mixed integer linear program also present bilevel algorithm solve directly proposed bilevel model implemented tested models algorithm results show bilevel algorithm better terms running time size instances solved
drought water loss soil erosion main factors limiting agricultural production semi arid regions china field study conducted determine runoff efficiencies different ridge widths covered different materials common plastic film biodegradable mulching film manual compacted soil effects different ridge furrow ratios ridge covering materials soil water storage topsoil temperature hay yield grain yield water use efficiency wue oats ridge furrow rainwater harvesting rfrh system dingxi agri meteorological station consecutive years average runoff efficiency bmr bmr bmr cmr cmr cmr bmr cmr ridges compacted soil covered biodegradable mulch film common plastic film respectively subscript numbers stand ridge widths years respectively field experiment using oats indicator crop showed mulching materials ridge widths distinct effects topsoil temperature top ridges bottom furrows soil water storage depth soil bottom furrows increased increasing ridge widths order cmr approximate bmr flat planting total precipitation higher average rainfall leading significant increase hay grain yield cmr equivalent hay grain yield bmr compared cases system positive effects rainwater harvesting could compensate negative effects planting area reduction resulting decrease hay grain yield compared average grain yield decreased increased bmr bmr bmr cmr cmr cmr years respectively wue bmr cmr times greater years increased increasing ridge width optimum furrow width cmr bmr future study needed investigate impact rfrh crop production wue economic benefit different precipitations soil types slopes plant species using biodegradable mulching materials elsevier rights reserved
understanding causes human behavior essential advancing one interests coordinating social relations scientific study people arrive understandings explanations unfolded four distinguishable epochs psychology characterized different metaphor researchers used represent people think attribute causality blame individuals first epoch guided intuitive scientist metaphor emphasized whether observers perceived behavior caused unique tendencies actor common reactions requirements situation metaphor displaced second epoch intuitive lawyer depiction focused need hold people responsible misdeeds third epoch dominated theories counterfactual thinking conveyed person reconstructor approach emphasized antecedents consequences imagining alternatives events especially harmful ones current upsurge moral psychology fourth epoch emphasizes moral evaluative aspect causal judgment reflected person moralist metaphor tracing progression person environment distinction early attribution theories present concerns moral judgment goal clarify causal constructs used relate one another unique attributional problems addresses
seasonal adaptations enabling bridging periodic challenging abiotic conditions taxonomically widespread however sensitivity environmental stresses heightened periods several temperate insects wintering strategies play key ecosystem economic roles including wild bee pollinators example hibernation survival temperate bumblebees crucial new queens future social colonies winter bees also faced abiotic biotic stressors linked recent pollinator declines exposure pesticides parasites using fully crossed experiment influence dietary exposure neonicotinoid insecticides thiamethoxam clothianidin prevalent bumblebee parasite crithidia bombi hibernation survival hibernation weight change bombus terrestris bumblebee queens investigated neonicotinoid bombi exposures reduced hibernation success individually additive synergistic effects stressors found effects asynchronous early neonicotinoid effects hibernation mortality overriding later parasite effects combined exposures neonicotinoid exposure also increased hibernation weight loss surviving queens diapause periods employed numerous temperate organisms likely especially vulnerable environmental stresses besides seasonal challenge periods adaptation thus diapause requires inclusion consideration impacts stresses accordingly demonstrated naturally relevant exposures pesticides parasites important detrimental effects bumblebees critical hibernation period potential consequences populations key wild pollinators
psoriasis immune mediated chronic inflammatory disorder manifests dermatologic lesions psoriatic arthritis psa cases psoriasis associated multiple comorbidities including metabolic syndrome hypertension diabetes cardiovascular events obesity psychiatric disorders affect course sleep disorders systematic review literature relationship psoriasis psa formal sleep disorders identified studies increased prevalence obstructive sleep apnea osa prevalence psoriasis versus general population also increase prevalence restless legs syndrome psoriasis versus european north american samples wide variety insomnia criteria used studies resulted insomnia prevalence psoriasis insufficient show elevated prevalence general population prevalence chronic insomnia prevalence transient insomnia evidence symptoms insomnia psoriasis directly mediated pruritus pain treatments decrease cutaneous symptoms psoriasis successful mitigating insomnia show improvements osa relationship psoriasis multifactorial authors published elsevier ltd
alemtuzumab conditioning highly effective reducing incidence acute chronic graft versus host disease gvhd reduced intensity fludarabine melphalan transplantation cyclosporine monotherapy less frequent lower dose scheduling may used sibling donors optimal regimen matched unrelated donors defined retrospective observational study patients incidence severity gvhd compared patients receiving different dose schedules standard regimen days days days patients treated developed acute gvhd grades incidence respectively whereas developed chronic ghvd excess severe acute grades iii gvhd observed cohort versus relative risk severe acute grade gvhd remained fold higher cohort compared cohort adjustment differences hla match age gender mismatch cytomegalovirus risk diagnosis findings indicate alemtuzumab schedule comparable schedule attenuated schedules may increase risk severe grade gvhd american society blood marrow transplantation published elsevier inc rights reserved
four kinds fatigue cracks found suspension bridge orthotropic steel deck finite element analysis conducted investigate reason fatigue cracks originated cope hole transverse crossbeams stresses surround cope holes crossbeam calculated vehicle loads imposed scheduled positions bridge deck relationship peak stresses surround cope hole loading position acquired areas effects stress concentration surround cope hole named area area calculation results indicate peak stress area greater allowed fatigue stress range million cyclic loads actual position fatigue crack detected bridge coincide position area
aims objectives describe perceived social support among patients coronary heart disease following percutaneous coronary intervention background low level social support considered risk factor coronary heart disease healthy individuals reduces likelihood people diagnosed coronary heart disease good prognosis design descriptive cross sectional study methods survey patients conducted self report instrument social support people coronary heart disease used instrument comprises three dimensions social support informational emotional functional supports background variables data analysed using descriptive statistics factor analysis mean sum variables multivariate logistic regression results perceived informational support primarily high respondents risk factors target level weakest items informational support advice physical activity continuum care rehabilitation regarding items emotional support support cardiac patients weakest weakest item functional support respondents sense healthcare professionals care patients coping disease background variables associated perceived social support gender marital status level formal education profession physical activity duration coronary heart disease previous myocardial infarction conclusions healthcare professionals pay extra attention women single patients physically inactive patients demonstrating lower level education longer duration chd respondents without previous acute myocardial infarction continuum care counselling important ensure especially among relevance clinical practice study provides evidence healthcare professionals aware individual needs social support among patients coronary heart disease percutaneous coronary intervention
homogeneous charge compression ignition hcci engines promising alternative traditional spark compression ignition engines due potential achieve high thermal efficiency near zero emissions nox soot work heat transfer bulk gas cylinder wall measured motored hcci operation single cylinder cfr engine fueled heptane heat flux measurements cylinder wall head show small spatial variation heat flux combustion chamber design experiments methods applied study effect engine settings heat transfer found inlet air temperature affect heat flux motored operation fired operation engine settings affect heat transfer none interactions significant compression ratio inlet air temperature quadratic effect peak heat flux peak convection coefficient whereas mass fuel rate linear effect total heat released compression ratio inlet air temperature linear effect mass fuel rate quadratic effect engine settings affect instantaneous heat flux elsevier ltd rights reserved
paper proposed type metal foams filled thermoelectric generator teg waste heat recovery metal foam inserts three kinds pore densities ppi ppi ppi included considering heat transfer enhancing features porous metal mediums flow channel detachable prototype designed experimentally investigate influence metal foams performance thermoelectric waste heat recovery twhr system operating parameters experimented improve thermoelectric power generation efficiency including hot air inlet temperature cold water flow rate metal foam pore density thermoelectric module tem connecting mode moreover twhr performance system evaluated power generation efficiency heat exchange effectiveness waste heat recovery rate respectively results showed filling metal foams flow channels could effectively enhance performance twhr system maximum power generation efficiency teg filled ppi metal foams higher value unfilled teg elsevier ltd rights reserved
individuals autism spectrum disorder asd early accurate diagnosis enables early intervention leads improved quality life diagnostic label asd recognized vietnam since number children diagnosed increased dramatically however limited understanding condition article aims describe current assessment diagnostic practices hanoi vietnam low resource setting data article came depth interviews parents children asd service providers observation health clinics early intervention centers provide asd assessment field work july may study reveals although improvement assessment services parents still face number challenges accessing quality assessment diagnosis asd vietnam include rushed perfunctory assessment lack clinical guidelines assessment limited communication among health professionals assessment teams professionals parents children asd public awareness raising signs autism capacity building professionals development practical contextual appropriate assessment protocols needed enhance accessibility quality assessment services
paper presents method touch based gesture recognition used human centered interfaces ambient intelligence applications gestures associated shapes represented using fourier coefficients neural networks decision trees naive bayes set classifiers based linear discriminant analysis tested gesture recognition methods evaluated based accuracy training recognition time also application controlled user using touch based gestures implemented
continuous conduction mode power factor correction converters widely employed front stage power supplies medium high output power second order reactive input power single phase systems causes second order ripple link voltage speed voltage regulation thus limited second order frequency seeking achieve low distorted input current study presents fast second order voltage estimation method wherein integrator used estimation second order voltage ripple obtain rapid voltage feedback without ripple thereby cope limitations imposed second order frequency approach greatly expands bandwidth voltage control loop beyond second order frequency reducing total harmonic distortion associated input current also makes possible reduce capacitance reduce costs authors opted full digital control using dsp conjunction feedback plus feedforward control facilitate design current loop feedback current corrector used reduce distortion associated input current wide load range effectiveness proposed control method confirmed simulation experimental results
zinc modeling language conceptual model automatically mapped different design models using well known solving techniques constraint programming mathematical methods local search result zinc solver technique independent since original conceptual models may nonlinear mapping linear solvers requires models linearized first paper introduce linzinc new library zinc includes necessary functions linearize high level data structures expressions zinc models interesting point thanks extensibility zinc linzinc written zinc instead implemented compiler used linzinc linearizing set well known nonlinear models experimental results show one hand significant overhead linearizing models hand linearized models sometimes faster original models using proposed approach zinc users implement linearizing techniques without need change language without anxious mapping overhead
paper devoted study several stability properties aubin lipschitz like property calmness isolated calmness special non monotone generalized equation theoretical results applied theory non regular electrical circuits involving electronic devices like ideal diode practical diode diode alternating current
high performance electric motor drive systems used continuous positive airway pressure cpap device paper proposes dynamic modeling control cpap device electrical mechanical components model developed paper closed loop permanent magnet motor drive based field oriented control foc implemented provide required pressure flow patient different breathing patterns extensive simulations carried evaluate electric motor drive system performance different patient conditions
teaching environment changed lot information based society today educational circle advocating reach optimization respect using innovative instruction technology teaching means aids teaching media playing role modernization teaching facilities largely depends ability teacher uses education technology capacity article illustrates difference contact education technology information technology article gives advice training based reflection innovative instruction technology capacity manufacturing engineering
context previous research found exposure violence home community electronic media associated children adolescents normative expectations concerning use violence indicators violent behaviors youth objective purpose study examine relationships frequency high school students reported watching wrestling television engaging date fighting weapon carrying fighting behaviors design initial analysis consisted cross sectional study simple random sample high school students followed longitudinal analysis students month period setting setting public high schools city county system participants used simple random sample students main outcome measures primary outcome variables included frequency date fighting previous months alcohol drug involvement associated last date fight results significant correlations frequency watching wrestling television previous weeks engaging date fighting fighting general weapon carrying males females although relationships stronger among females among males frequency watching wrestling highest among students reporting date fighting either victim perpetrator drinking alcohol using illegal drugs analyzed using logistic regression strongest relationships observed frequency watching wrestling date fight perpetration among females cross sectional longitudinal analyses findings persisted adjusting multiple factors conclusions males females frequency watching wrestling highest among students fought dates alcohol drugs involved association watching wrestling date fighting stronger among females males relationship watching wrestling television perpetrator dating violence also stronger among females remained consistent month time period
optimal microgrid design challenging problem especially multi energy microgrids electricity heating cooling loads well sources multiple energy carriers address problem paper presents optimization model formulated mixed integer linear program determines optimal technology portfolio optimal technology placement associated optimal dispatch microgrid multiple energy types developed model uses multi node modeling approach opposed aggregate single node approach includes electrical power flow heat flow equations hence offers ability perform optimal siting considering physical operational constraints electrical heating cooling networks new model founded existing optimization model der cam state art decision support tool microgrid planning design results case study compares single node multi node optimal design example microgrid show importance multi node modeling shown single node approaches incapable optimal der placement may also result sub optimal der portfolio well underestimation investment costs published elsevier ltd
purpose sought evaluate low contrast performance newly developed needle image plate line scanner nip computed radiography system comparison standard powder image plate flying spot scanner pip system materials methods total images cdrad phantom simulating low contrast structures different drill holes different diameters obtained imaging systems using different exposure variables images window level set generate consistent density contrast addition multiscale contrast dependent contrast amplification applied images images obtained printed presented total observers radiologists engineers physicists blinded image plate parameter setting used smallest detectable drill hole depth contrast correctly identified recorded diameter median values observed calculated tested statistical differences pip nip using student test matched pairs level significance results settings variables nip images depicted significantly lower contrast levels lower depth drill holes compared pip images settings also showed trend towards better low contrast depiction nip case low contrast performance better using pip images conclusion images obtained needle image plate line scanner provide superior low contrast performance compared images obtained powder image plate flying spot scanner
many computer vision applications require finding corresponding points images using corresponding points estimate disparity today correspondence finding algorithms primarily use image features pixel intensities common image pairs computer vision applications however produce desired results using correspondences derived image features pixel intensities two examples multimodal camera rig center region coaxial camera rig present image correspondence finding technique aligns pairs image sequences using optical flow fields optical flow fields provide information structure motion scene available still images used image alignment apply technique dual focal length stereo camera rig consisting visible light infrared camera pair coaxial camera rig test method real image sequences compare results state art multimodal structure motion sfm algorithms method produces accurate depth scene velocity reconstruction estimates state art multimodal sfm algorithms spie
pediatric lymphoma common sub saharan africa survival estimates often based limited follow incomplete retention introducing potential bias compared follow overall survival passive active tracing within prospective cohort children lymphoma malawi median follow times months interquartile range iqr months iqr passive active follow respectively twelve month overall survival confidence interval passive active follow passive follow significantly overestimated underestimated mortality efforts improve retention regional studies needed
intake pretreatment brine disposal cost reverse osmosis sea water desalination systems represent total cost desalinated water present study investigates effect reverse osmosis brine recycling employing adsorption desalination overall system desalinated water recovery adsorption desalination produces dual useful effects high quality potable water cooling effect reverse osmosis desalination simulated engineering equation solver ees brine leaving reverse osmosis system fed adsorption desalination system adsorption desalination driven low temperature heat source solar energy adsorption desalination system simulated matlab results show proposed combination system recovery increases permeate salinity decreases addition system performance improvements cooling effect generated utilized cooling applications elsevier rights reserved
computer aided design cad model shared cloud collaboration challenge encrypt confidential design features model effective knowledge protection paper presents novel encryption approach based geometric transformation encryption mechanisms feature based cad models supporting cloud enabled collaboration innovation approach centered enhanced encryption transformation matrix eetm characterized parametric randomized self adaptive feature encryption controllable parameters transforming features terms zoom deformation defined eetm facilitate users conduct encryption transformation flexibly random probability mechanism embedded parameters eetm order guarantee security encrypted model furthermore parameters eetm enhanced self adaptive ensure geometric validity encrypted model approach validated via number complex models demonstrate applicability effectiveness industrial applications
laboratory experiments conducted study dynamics sand jets passing two immiscible fluids different oil layer thicknesses nozzle diameters sand masses employed evolution oily sand jets time investigated using image processing boundary visualization techniques different shapes frontal head trailing wave section observed cloud formation classified different categories based reynolds number normalized oil layer thickness evolution time found effect reynolds number evolution oily sand jets significant parameters width frontal velocity oily sand jets measured different times observed oily sand jets became unstable distance ten times larger nozzle diameter instability oily sand jets caused intense spreading spreading rate thin layer oil encapsulated sand cluster ruptured due excess shear stress caused bursting frontal head cloud sand particles three different bursting mechanisms observed correlation found densimetric froude number normalized bursting time data mining boundary visualization techniques used model oily sand jets model trees developed classify predict growth oily sand jets different conditions modeling results indicated model tree predict growth sand jets uncertainty width velocity distance respectively
background enuresis results behavioural disorder children study investigated behavioural disorders children possessing primary enuresis materials methods cross sectional study children primary enuresis referred children hospital khorramabad census method used study data collected using short screening instrument enuresis psychological problems reliability validity confirmed previous studies first questionnaire used assess academic failure anxiety behavioural disorders sleep psychological disorders results obtained compared terms gender age statistical analyses using inferential descriptive statistics including chi square fisher test employed results average age children years sixty six per cent participants male rest female ninety per cent subjects age range years years old forty three per cent children suffered anxiety disorders sleep disorders also suffered academic failure among behavioural disorders hyperactivity restlessness common disorders significantly higher nine boys headache obsessive sleep disorders common children significant correlation eating disorders headache sleep disorders strange movements males feelings sadness common females conclusion social personality development children enuresis improved informing parents enuresis
propose vehicle power cooling heating cogeneration energy supply system vcess investigate thermodynamic characteristics various working conditions cogeneration system includes top engine cycle bottom waste heat recovery whr cogeneration cycle using zeotropic mixtures working fluids bottom cycle recovers exhaust coolant sensible heats top engine cycle different temperatures thermal match two whr evaporators condenser considered vcess model built verified via quantitative analysis energy demands waste heats characteristics commercial vehicle different working conditions thermodynamic performances vcess discussed considering actual vehicle energy demands proposed cogeneration system indicates prominent thermodynamic performance advantages ambient temperature lower comfort cabin temperature requirement overall thermal efficiency cogeneration system improved ratio exhaust heat coolant heat increased reaches maximal value highest vehicle speed refrigeration required optimal operation pressure ratio turbine inlet pressure condensing pressure working fluids composition exists given ambient temperature overall thermal efficiency cogeneration system decreases sharply extreme vehicle velocity extreme high ambient temperature elsevier ltd rights reserved
dengue virus denv four serotypes denv denv causative agent viral infection dengue denv nonstructural protein comprises serine protease domain rna helicase domain nucleotide triphosphatase activities essential rna replication viral assembly solution ray scattering used provide insight overall structure flexibility entire recombinant helicase protease domains dengue virus serotypes solution denv denv forms elongated flexible solution importance linker residues flexibility domain domain arrangement shown compactness individual protease helicase domains swapping ppavp linker stretch related hepatitis virus hcv denv alter elongated shape engineered mutant conformational alterations owing rna binding described protease domain undergoes substantial conformational alterations required optimal catalysis bound rna finally effects atpase inhibitors enzymatically active denv denv individual helicases presented insight allosteric effect inhibitor quercetin provided
paper applied intersectional approach analyse self representations female marriage migrants former soviet union married nationals basis depth interviews individuals husbands present study explored range topics related limited pre migration history partner choice post migration adjustment failures romantic relationships local partners cited men women primary reason turn transnational marriage market seek brides grooms respectively men looking traditional wives expected spouses assume roles housekeepers contrast majority migrant women pursued egalitarian gender relationships family conflict expected gender roles household division labour strained many relationships
study water quality marreco river municipality toledo brazil investigated part monitoring program conventional water pollution parameters turbidity conductivity cod ammonia total phosphorus metal elements analyzed acute toxicity bioassays conducted bacterial bioluminescence method using indicator vibrio fischeri evaluate toxic effect contaminants principal components analysis pca pearson correlation applied assess statistical correlation physicochemical parameters metals water samples strong evidence supported pearson pca analyses presence elevated levels associated anthropogenic activities installed river basin
hydraulic units often linked ecological habitat geomorphic structure better understanding turbulent characteristics units needed work examined near bed turbulent structure runs glides restored river investigated physical characteristics influenced near bed hydraulics units research completed three restored reaches one reference reach virginia tech stream research education management laboratory laboratory unique three different restoration treatments applied contiguously along stream restoration practices ranged passive active passive reach included cattle exclusion active reaches included cattle exclusion well vegetation plantings bank sloping construction inset floodplains three dimensional velocities measured near channel bed run glide biotopes within three restored reaches well upstream reference reach velocities utilized analyse compare near bed turbulent structure across reaches restoration activities address channel bed directly differences physical structure two physical biotopes observed among restoration treatments likely changes bank shape roughness due vegetation differences differences reference restored reaches still evident approximately years cattle exclusion construction activities differences observed hydraulic structure runs glides near bed flow structure runs glides related local roughness copyright john wiley sons ltd
large conductance voltage activated channels channels abundantly expressed throughout body important regulators smooth muscle tone neuronal excitability dysfunction implicated various diseases including overactive bladder hypertension erectile dysfunction therefore channel openers bear significant therapeutic potential treat diseases goslo compounds designed potent efficacious channel openers although structural activity relationships activation alpha alpha beta channels hypothetical mode action compounds studied detail recent years effectiveness open alpha gamma channels still remains unexplored study examined efficacy closely related goslo openers goslo goslo goslo using inside patches alpha channels coexpressed different lrrc gamma subunits hek cells data suggests activation effects due significantly affected presence gamma subunits interestingly effects efficacious channel opener altered different gamma subunits cells expressing bka channels shift induced whereas significantly reduced bkag channels anova alpha gamma channels less observed alpha gamma alpha gamma channels respectively additionally excitatory effects alpha beta specific channel opener partially restored patches containing alpha gamma channels together data highlights subtle modifications goslo structures alter effectiveness channels accessory subunits study might provide scaffold development tissue specific channel openers
rework stubborn issue construction industry drawing considerable attention industry academia past decades however far little effort made investigate reworks green building construction projects study aims assess status quo rework green building construction projects singapore identify evaluate rework factors green building construction projects compare criticalities conventional counterparts propose set feasible solutions achieve aims questionnaire survey administered data collected different construction companies analyzed results showed compared conventional building construction projects green building construction projects tended lower incidence rework suffered rework adverse impacts terms cost overrun schedule delay results also showed top four critical rework factors green building construction projects owner change design change design error omission contractor error omission addition study proposed five practical solutions help curb reworks green building construction projects study contributes body knowledge examining rework problem green building construction projects meanwhile study contributes industry providing practitioners depth understanding rework green building construction projects specific solutions proposed study also offer industry practitioners direct help reducing works projects
core detector response calculation important part reactor design however response function measured experiments quantitatively core detector response simulation therefore required decades code used dedicated tool nowadays engineers expressing interest using monte carlo method instead method simulations expected monte carlo method give higher accuracy paper modeling simulation core detector responses briefly reviewed based korean kori unit reactor differences simulation monte carlo simulation compared sensitivity computational conditions also discussed shown problem dependence cross sections meshing dependence spatial discretization core detector response calculations strong expected however ray effect main shortcoming calculation based analysis two benefits shown using mcnp direct calculation firstly impact ray effect eliminated without using angular discretization secondly direct calculation easier perform based powerful ability modeling parallel computing monte carlo code new drf values adopted dynamic control rod reactivity measurement kori unit reactor results show new drf values improve error measured control rod worth percentage elsevier ltd rights reserved
mining big data big data mining become active research area difficult using current methodologies data mining software tools single personal computer efficiently deal large datasets parallel cloud computing platforms considered better solution big data mining concept parallel computing based dividing large problem smaller ones carried one single processor individually addition processes performed concurrently distributed parallel manner two common methodologies used tackle big data problem first one distributed procedure based data parallelism paradigm given big dataset manually divided subsets algorithms respectively executed corresponding subsets final result obtained combination outputs produced algorithms second one mapreduce based procedure cloud computing platform procedure composed map reduce processes former performs filtering sorting later performs summary operation order produce final result paper aim compare performance differences distributed mapreduce methodologies large scale datasets terms mining accuracy efficiency experiments based four large scale datasets used data classification problems results show classification performances mapreduce based procedure stable matter many computer nodes used better baseline single machine distributed procedures except class imbalance dataset addition mapreduce procedure requires least computational cost process big datasets elsevier inc rights reserved
thesis analyzed features complex mechanical system introducing complex system science using basic theories based features complex mechanical system theory system decomposition relations factors variable new method raised man machine design complex mechanical system topological constraint design tcd case given demonstrate possibility effectiveness tcd
investigated current characteristics large conductance voltage activated channels human urine derived stem cells huscs effect channels proliferation differentiation huscs fresh human urine collected healthy donors isolate huscs human kcnma gene silencing shrna used regulate expression huscs ibtx channel antagonist channel agonist used examine effect channels huscs whole cell patch clamping employed detect current channels flow cytometry immunofluorescence western blotting used analyze cell cycle related protein levels results showed activities channels significantly decreased induced huscs endothelial urothelial smooth muscle cells compared huscs normalized cell capacitance addition average channel current density huscs significantly decreased upon silencing channel expression hnrna apoptosis rates huscs iberiotoxin ibtx hnrna treatment groups significantly increased compared control group whereas treatment agonist decreased apoptosis rates compared control group huscs phase significantly decreased ibtx hnrna treatment groups conclusion channels play important role maintaining proliferation differentiation huscs overexpression channels huscs provide basis future clinical application overactive bladder
performativity social protest renders vulnerable omissions distortions media violence invariably seduces television leads criminalization repression paper examine actions mexican social movements faced media omission end specific examples reveal major media groups criminalize distort protests similarly analyze alternative communication experiences interviewing actively participate said processes
paper mainly introduces novel deep learning mapping dlm framework oriented ternary change detection task information unbalanced images different traditional intensity based methods available dlm framework based operation features extracted two images due excellent performance deep learning information representation feature learning two networks used first stacked denoising autoencoder used two images serving feature extractor sample selection process stacked mapping network employed obtain mapping functions establishing relationship features class finally comparison features made final ternary map generated clustering comparison result work highlighted two aspects firstly previous works focus two images similar properties whereas dlm framework based two images quite different properties usually encountered case secondly dlm framework based analysis feature instead superficial intensity avoids corruptions unbalanced information large extent parameter tests three datasets provide appropriate parameter settings corresponding experimental results demonstrate robustness effectiveness terms accuracy time complexity
rapid growth digital data storage medical health social media education many world amplified demand big data storage requires trillion files exabytes data growth data put key question effectively manage find data emergent ocean information upcoming demand data storage petabytes exabytes data also resulted putting pressure organizing file structure way retrieval results searching keyword match growing pace data storage result increase demand keyword indexing searching file systems directly implementing searching methodology file system resulted inefficient inconsistent results general purpose indexes may suitable file system searching relies relational databases may limit scalability performance proposed bilingual framework english hindi addresses problems novel approach indexing searching queries large scale file system
impact water resources caused municipal wastewater discharges become critical ever growing environmental public health problem order able efficiently address problem important adopt integrated approach includes decrease control contamination source principles successfully applied industrial sector concepts also applied integrated water resources management context conceptual model three steps strategic approach ssa developed consisting minimization prevention treatment reuse stimulated natural self purification paper focused first step assessment includes case study expansion area city cali colombia new inhabitants evaluation alternatives done using two different system boundaries reduction water supply costs households savings associated drinking water infrastructure avoided costs infrastructure additional sewerage wastewater treatment facilities taking account reduction water supply costs households savings associated drinking water infrastructure alternatives minimization prevention hierarchized using analytic hierarchy process grey relational analysis cost benefit analysis carried compare highest ranked alternatives conventional approach considers business usual scenario high water use end pipe wastewater treatment plant conventional water supply system drinking water quality uses best minimization prevention alternatives cali expansion zone found consider dual flush toilets possibility using rainwater harvesting laundry purposes however minimization prevention alternatives considered viable implemented household units elsevier ltd rights reserved
explaining prevalence overconfident belief one better others prior work focused motive maintain high self esteem abetted biases attention memory cognition additional possibility overconfidence enhances person social status tested status enhancing account overconfidence studies studies found overconfidence leads higher social status short longer term groups using naturalistic experimental designs study applied brunswikian lens analysis brunswik found overconfidence leads behavioral signature makes individual appear competent others studies measured experimentally manipulated desire status found status motive promotes overconfidence together studies suggest people might often believe better others helps achieve higher social status
computer aided diagnosis cad alzheimer disease drawn attention computer vision research community last years several attempts made adapt pattern recognition approaches specific neuroimaging data structural mri smri early diagnosis one strategy boost discrimination power approaches integrating complementary imaging modalities single learning framework diffusion tensor imaging dti new promising modality giving complementary information anatomical mri however including relevant dti information modality challenging problem paper propose extract local image derived biomarkers dti smri construct multimodal signatures assess relevance modalities well optimize classifier integrate complementary information using multiple kernel learning mkl framework subjects recognition evaluate method perform experiments subset alzheimer disease neuroimaging initiative adni dataset weighted mri mean diffusivity maps dti modality patients normal control mild cognitive impairment mci subjects used obtained results indicate multimodal approach yields significant improvement accuracy using single modality independently classification accuracies obtained proposed method respectively mci mci binary classification problems mci classification problem proposed fusion framework leads average increase least accuracy specificity sensitivity elsevier rights reserved
near future know vehicles communicate make vehicular hoc network gives concept intelligent transportation system paper presented review security vanet consequently several researchers represented attacks solutions vehicular communication analyzed security problems proposed solutions overcome discussed need robust vehicular hoc networks strongly dependent security privacy features paper review existing attacks vanet perspective approach security also provided solutions particular attack vanet
introduction case control study compares patients healthy elbows group symptomatic patients cartilage damage osteoarthritis materials methods control group recruited routine medical examinations patients general medical offices included case group total patients undergoing arthroscopy result chronic elbow discomfort patients questioned regard occupational stress athletic stress results significantly increased risk cartilage damage osteoarthritis found subjectively perceived increased stress occupational settings individual stresses elbow joint occupational settings following severities effects found exposure heavy work force vibration repetition elbow stressing sport types represent potential risk factor development cartilage damage osteoarthritis elbow joint conclusions cartilage damage radiographic osteoarthritis elbow joint rare respect overall prevalence osteoarthritis large number patients cartilage damage radiographic osteoarthritis elbow joint occupational athletic stress factors injuries sustained addition causes rheumatism gout prove possible causes secondary symptomatic forms osteoarthritis
microrna signatures bal cells alveolar macrophages currently lacking ipf sought investigate expression fibrosis related micrornas cellular component bal ipf thus focused micrornas previously associated fibrosis mir mir mir let mir rapid ipf progression mir mir mir mir mir among tested micrornas mir mir found significantly downregulated ipf mir mir expressed bal cells importantly downregulation mir inversely correlated significantly increased levels cola mrna ipf bal cells collagen found mainly overexpressed alveolar macrophages cell types bal immunofluorescence view downregulation mir tested response thp macrophages profibrotic cytokine tgfb observed downregulation mir conversely proinflammatory stimulation lead mir upregulation upon examination mrna levels known mir targets akt dnmt hmga significant correlations observed bal cells however increased levels total akt akt ser phosphorylation observed ipf bal cells furthermore mir inhibition thp macrophages resulted significant increase aktser phosphorylation study highlights importance bal microrna signatures ipf identifies significant differences mir akt mir collagen axes bal cells ipf patients
background magnetic resonance imaging markers widely used detect quantify white matter pathologies multiple sclerosis recently developed diffusion basis spectrum imaging dbsi distinguish quantify existing axonal injury demyelination inflammation multiple sclerosis patients animal models could serve longitudinal marker axonal loss primary cause permanent neurological impairments disease progression methods eight week old female cbl mice underwent optic nerve dbsi followed week long recuperation prior active immunization experimental autoimmune encephalomyelitis eae visual acuity mice assessed daily longitudinal dbsi performed mouse optic nerves baseline naive immunization onset optic neuritis tissues perfusion fixed final vivo scans correlation dbsi detected pathologies corresponding immunohistochemistry markers quantitatively assessed results cohort eae mice monocular vision impairment occurred animals vivo dbsi detected differentiated quantified optic nerve inflammation demyelination axonal injury loss correlating nerve pathologies visual acuity different time points acute optic neuritis dbsi quantified presence optic nerve swelling similar axonal loss onset optic neuritis eae mice conclusions findings support notion axonal loss could occur early eae mice dbsi detected pathologies posterior visual pathway unreachable optical coherence tomography without confounding inflammation induced optic nerve swelling dbsi could thus decipher interrelationship among various pathological components role plays disease progression quantification rate axonal loss could potentially serve biomarker predict treatment outcome determine progressive disease starts
tend express positive judgments behaviors toward individuals belonging group compared groups study assessed role cerebellum dorsomedial prefrontal cortex dmpfc two regions critically implicated social cognition processes mediating implicit valenced attitudes toward group group individuals aim used transcranial magnetic stimulation tms combination standard attitude priming task caucasian participants categorize valence series adjectives primed either group group face two behavioral experiments found group bias faster categorization positive adjectives preceded group faces evidence group bias interestingly tms dmpfc right cerebellum significantly interfered modulation exerted group membership adjective valence classification abolishing group bias observed baseline overall data suggest dmpfc cerebellum play causal role mediating implicit social attitudes
sociological interpretation reality processes occurring determined various approaches understanding nature diversity approaches eventually reduced definition reality social world reflects one hand objectively existing phenomena processes hand people subjective perceptions objective reality social actuality objective social reality exists beyond subject social cognition objectively new generation inherits parent generations complex system economic social political structures institutions organizations established relationships form social infrastructure objective reality social reality people perceive directly part objective reality knowledge due knowledge particular sphere different objects reality people get less adequate subjective perception therefore study social reality focuses process formation subjective ideas objects social actuality attitudes included subject area sociology knowledge standpoint sociology knowledge research object reality ideas reality based subjective perceptions reality people construct reality perceptions change influence various factors affecting changes social reality process formation significant change factor crisis affects spheres russian society article analyzes impact crisis changes social reality different population groups russia way reflected people attitudes family work education based analysis data nationwide studies revealed contradiction russians traditional attitudes family work education emerging modern attitudes amid crisis contradiction tends exacerbate due impossibility maintaining traditional principles underlying old way life leads uncertainty formation new forms certainty change life paradigm
research internal model based method proposed estimate displacement profile bridge subjected moving traffic load using combination acceleration strain measurements structural response assumed within linear range deflection profile assumed dominated fundamental mode bridge therefore requiring knowledge first mode still holds true multiple vehicle loading situation high mode shapes impact response structure using structural modal parameters partial knowledge moving vehicle load internal models structure moving load respectively established used form autonomous state space representation system structural displacements velocities accelerations states system fully observable measured output contains structural accelerations strains reliable estimates structural displacements obtained using standard kalman filtering technique effectiveness robustness proposed method demonstrated evaluated via numerical simulation simply supported single span concrete bridge subjected moving traffic load
school prison pipeline stpp refers path education system juvenile adult criminal justice system past two decades path grown significantly scholars attribute myriad contributing factors increase factor impact consequences covered detail based extensive literature review macro practice race matters juvenile justice prior stpp concept education largely considered protective factor children route success opposed risk factor track toward juvenile justice involvement staying school getting good grades regarded strategies even risk students could use overcome poverty prejudice powerlessness since approach discipline public schools changed effects change becoming evident article explains correlates stpp disparate outcomes notably students color disabilities lesbian gay bisexual transgender queer questioning students article concludes implications social workers various settings specific strategies reducing impact stpp
cardiovascular disease cvd leading cause death today incorporates wide range cardiovascular system malfunctions affect heart functionality believed hemodynamic loads exerted cardiovascular system left ventricle particular leading cause cvd initiation propagation moreover believed diagnosis prognosis cvd early stage could reduce high mortality morbidity rate therefore set robust clinical cardiovascular assessment tools introduced compute cardiovascular hemodynamics order provide useful insights physicians recognize indicators leading cvd also aid diagnosis cvd recently combination computational fluid dynamics cfd different medical imaging tools image based cfd cfd widely employed cardiovascular functional assessment providing reliable hemodynamic parameters even though capability cfd provide reliable flow dynamics general fluid mechanics problems widely demonstrated many years clinical implications cfd patient specific lvs applicable due limitations complications paper review investigations conducted numerically simulate patient specific human past years using cfd methods firstly divide different studies according different types physiological different pathological conditions chosen reconstruct geometry discuss contributions methodologies limitations findings regard studied cfd simulations intraventricular flows related cardiology insights physiological patient specific models pathological heart patient specific models including myocardial infarction dilated cardiomyopathy hypertrophic cardiomyopathy hypoplastic left heart syndrome finally discuss current stage cfd simulations order mimic realistic hemodynamics patient specific lvs conclude heart flow simulation right track developing useful clinical tool heart function assessment incorporating heart structures heart valves operations providing useful diagnostic indices based hemodynamic parameters routine adoption clinical usage
objective hypothesize shape essure microinsert ultrasound able predict complications evident hysterosalpingogram hsg accepted gold standard method materials july july women institution received essure microinsert placement purpose permanent sterilization coronal plane transvaginal ultrasounds performed three months essure microinsert placement patients complications identified ultrasound non diagnostic ultrasound following difficult insertion referred hsg patients hsg ultrasound performed retrospectively selected anonymized ultrasounds reviewed single blinded radiologist total microinserts patients described ultrasound using numeric grading system compared hsg findings results microinsert placement resulted complications identified ultrasound including uterine tubal perforations placement endometrial cavity sensitivity essure microinsert shape ultrasound predicting complications compared standard hsg positive predictive value specificity negative predictive value kappa coefficient conclusion results suggest ultrasound may used frontline imaging modality patients essure microinsert placement
hepatocellular carcinoma hcc common fatal malignancy liver sorafenib small molecule multikinase inhibitor acts different cancer cell lines used treatment hcc however advanced hcc patients fail respond sorafenib lack meaningful clinical benefit interferon lambda ifn lambda type iii interferon antiviral antiproliferative immunomodulatory functions evaluated use ifn adjuvant treatment sorafenib hcc present study cck colony formation assay results showed treatment combination ifn sorafenib suppresses viability hepg smmc liver cancer cell lines treatment either alone addition flow cytometry results confirmed treatment combination ifn sorafenib promotes loss mitochondrial membrane potential induces production ros treatment either alone furthermore using subcutaneous smmc tumor model treatment combination ifn sorafenib significantly reduced tumor growth volume induced apoptosis compared treatment sorafenib alone results show combined treatment ifn sorafenib facilitates synergistic effect suppressing hcc cancer growth promoting cell apoptosis vitro vivo thus ifn combination sorafenib might prove useful adjunctive strategy clinical treatment hcc elsevier masson sas rights reserved
supply electrical power usually achieved generator driven prime mover form mechanical drivetrain electromechanical system natural resonant modes electrical mechanical subsystems electrical generator provides coupling subsystems transferring useful power also disturbances electrical mechanical domains disturbances may excite resonances resulting cross domain electromechanical interaction lead lifetime reduction mechanical components instability electrical network resulting poor reliability wider system potentially catastrophic component failure electromechanical interaction particularly critical power generation systems onboard aircraft generator driven gas turbine via inherently low stiffness drive train critical identify electromechanical interaction design stage issues avoided however predicting occurrence interaction simulation challenging requiring multidomain models operating different time scales paper analyzes aircraft auxiliary power offtake produce reduced order mechanical drivetrain model allowing modal frequencies predicted cross domain interactions modeled purpose built electromechanical test platform used validate model demonstrate electrical disturbances passed generator mechanical system affect electrical network future research use test bed demonstrate strategies avoiding suppressing unwanted interactions
dipeptidyl peptidase dppi lysosomal cysteine protease derived immune granule cells suggested playing important role development rheumatoid arthritis study coumarin based fluorescent probe afc designed synthesized evaluate dppi activity serum tissue homogenates collagen induced arthritis cia rats inflammatory arthropathy model revealed fluorescent intensity significantly increased short time specific substrate afc reacted dppi fluorophore afc released shine cleavage reaction examined nmr spectroscopy shown dppi hydrolyzed afc robust linear time dependent manner significant high rate serum based dppi activity assay validated spiking gradient dilution methods interferences auto fluorescence observed coefficient variance calculated serum based dppi activity assays indicates good reproducibility good correlation seen serum dppi levels severity arthritis development cia rats study demonstrated new serum based diagnostic assay detecting dppi activity using coumarin conjugated fluorescent afc substrate successful implementation case would provide beneficial experience rheumatoid arthritis research elsevier ltd rights reserved
patients advanced cancer frequently experience anxiety depression poor quality life qol well physical symptoms fatigue weakness physical exercise potential help control symptoms optimal training prescription still clear performed study comparing medical qigong standard endurance strength training set patients advanced stage non small cell lung nsclc gastrointestinal cancers randomized cross study performed patients advanced nsclc cancers receiving eligible chemotherapy patients received supervised set twice weekly weeks psychological functioning qol symptoms physical functioning assessed intervention period nineteen patients completed interventions comparing interventions revealed difference set change anxiety depression scores qol however set treatment better improving perceived strength walking distance order interventions performed significant impact improvement certain symptoms sleep quality breathlessness qol walking distance cases beneficial effects exercise interventions markedly reduced second interval set equivalent impact many aspects psychological function cancer patients however set leads greater improvements exercise capacity helps reduce symptoms reduction beneficial effect set exercise function offered second intervention new finding warrants study
hagopian rooker zarcone evaluated model subtyping automatically reinforced self injurious behavior sib based sensitivity changes functional analysis conditions presence self restraint current study tested generality model applying datasets automatically reinforced sib published identified datasets included sufficient data permit subtyping similar original study subtype sib generally amenable treatment using reinforcement alone whereas subtype sib conclusions could drawn subtype sib due small number datasets nevertheless findings support generality model suggest sensitivity sib disruption alternative reinforcement important dimension automatically reinforced sib findings also suggest automatically reinforced sib longer considered single category additional research needed better understand treat subtype sib
along progress computer hardware architecture computational power order overcome technological bottlenecks software applications make use expert intelligent systems must race time nanoseconds matter long awaited future possible integration excellent solvers software engineering methodologies provide optimization based decision support planning since logistics market growing rapidly optimization routing systems primary concern motivates use vehicle routing problem vrp solvers software components integrated optimization engine critical success factor routing optimization quality response time performance less time consuming efficient automated processes achieved employing stronger solution algorithms study aims solve vehicle routing problem simultaneous pickup delivery vrpspd popular extension basic vehicle routing problem arising real world applications pickup delivery operations simultaneously taken account satisfy vehicle capacity constraint objective total travelled distance minimization since problem known hard hybrid metaheuristic algorithm based ant colony system acs variable neighborhood search vns developed solution vns powerful optimization algorithm provides intensive local search however lacks memory structure weakness minimized utilizing long term memory structure acs hence overall performance algorithm boosted proposed algorithm instead ants vns releases pheromones edges ants provide perturbation mechanism integrated algorithm using pheromone information order explore search space jump local optima performance proposed acs empowered vns algorithm studied well known benchmarks test problems taken open literature vrpspd comparison purposes numerical results confirm developed approach robust efficient terms solution quality cpu time since better results provided shorter time benchmark data sets good performance indicator elsevier ltd rights reserved
background little known whether family economic status might influence long term years outcome persons schizophrenia community aim examine differences outcome year follow persons schizophrenia high versus low family economic status backgrounds chinese rural area method prospective year follow study conducted six townships xinjin county chengdu china participants schizophrenia identified epidemiological investigation people aged years older followed results individuals low family economic status mean significantly higher rate homelessness lower rate survival high family economic status mean respectively individuals low family economic status significantly lower rates marriage complete remission higher mean scores positive negative syndrome scale panss lower mean score global assessment functioning gaf high family economic status predictors low family economic status individuals encompassed baseline low family economic status poor families attitude toward patient younger age older age first onset longer duration illness conclusion low family economic status predictive factor poor long term outcome persons schizophrenia rural community individuals family economic status considered making mental health policy providing community based mental health services
background developmental dysplasia hip ddh common pathological condition musculoskeletal system infants results congenital developmental malformation hip joint ddh spectrum pathologies affecting infant hip ranging asymptomatic subtle radiographic signs mild instability frank dislocations acetabular dysplasia saudi family three affected individuals ddh identified genetic analysis performed detect possible genetic defect underlying ddh affected members family methods performed whole genome genotyping using illumina humanomni array whole exome sequencing wes using nextera rapid capture kit illumina nextseq instrument four individuals family ddh results snp data analysis identify runs homozygosity copy number variations identity descent ibd analysis whole genome genotyping data identified shared haplotypes chromosome affected individuals analysis wes data identified rare heterozygous variants hspg atpb genes affected individuals multiple prediction software predicted variants identified damaging moreover silico analysis showed hspg regulates atpb expression using variety transcription factors conclusion results indicate might functional epistatic interaction hspg atpb ddh family studied due combined effect variants variants also present asymptomatic mother suggesting variants hspg atpb incompletely penetrant study provides first evidence digenic inheritance ddh family extends spectrum genetic heterogeneity human disorder
blue nile basin ethiopian highlands rainfall distribution extremely uneven spatially temporally drought frequently results crop failure high rainfall intensities result low infiltration high runoff causing soil erosion land degradation combined factors contribute low agricultural productivity high levels food insecurity poor land management practices coupled lack effective rainwater management strategies aggravate situation past two decades however government ethiopia attempted address many issues large scale implementation number soil water conservation measures despite success interventions uptake adoption remains low conceptual framework study based premise farmers likely adopt combination rainwater management technologies adaptation mechanism climate variability agricultural production constraints contrasts previous work typically examined single technology without considering interdependence technologies data used study come household survey seven watersheds ethiopian blue nile basin multivariate probit model used account potential correlation interdependence various components rainwater management technologies results suggest rainwater management technologies related hence effort promote adoption rainwater management technologies consider interdependence technologies failure may mask reality farmers face set choices adoption decisions
objective adolescent suicidal behavior public health concern south africa purpose article report development screening tool teachers identify south african students risk suicidal behavior need addressed within context limited number mental health professionals available provide screening care services south africa method grade students participated completing sociodemographic questionnaires self report psychometric instruments screening tool suicidal behavior developed using phase approach results twelve factors high risk suicidal behavior identified included screening tool research needed validate screening tool findings provide useful preliminary starting point teachers refer students high risk suicidal behavior mental health services treatment conclusion screening tool based factors identified associated suicidal behavior local research south african adolescents tool contributes research adolescent mental health particularly suicidal behavior developing low middle income countries like south africa aim creating african prevention intervention programs
according recent theories social cognition based two different types information processing implicit action based one explicit verbal one present study examined whether implicit explicit social cognitive information processing interact investigating young children adults use verbal explicit information predict others actions employing eye tracking measure anticipatory eye movements measure implicit processing experiment presented year old children well adults agents announced move either two possible targets results show year old children adults year old children able use verbal information correctly anticipate others actions yet experiments showed year old children able use explicit information give correct explicit answer experiment able use statistical information anticipate actions experiment overall study line theoretical claims two types information processing underlie human social cognition shows two inform years age elsevier rights reserved
hiv translating initiatives depression effective solutions project conducted randomized controlled effectiveness implementation trial comparing depression collaborative care enhanced usual care veterans health administration hiv clinics offsite hiv depression care team including psychiatrist depression care manager dcm clinical pharmacist provided collaborative care using stepped care model treatment made recommendations providers electronic health record system dcm delivered care management hiv patients phone calls performing routine assessments providing counseling self management problem solving dcm documented calls patient electronic medical record paper present results interviews conducted patients clinical staff multi stage formative evaluation conducted semi structured interviews hiv patients clinical staff three participating sites trial period gather experiences perspectives concerning intervention components interviews transcribed verbatim analyzed using rapid content analysis techniques patients reported high satisfaction depression care manager dcm phone calls hiv mental health providers reported dcm chart notes electronic health record helpful felt dedicated dcm hiv patients ideal meet patient needs sites encountered barriers achieving maintaining universal depression screening greater success screening incorporated routine intake processes results demonstrated depression care management via telehealth offsite team acceptable helpful hiv patients providers given centralized offsite depression care team deliver effective cost effective cost saving services multiple hiv clinics different locations high patient provider satisfaction broad implementation considered
feedback long mysterious effect either fixed ruined circuits phase loop gain analysis served maintain view feedback difficult handle interpret paper unified approach circuit analysis presented readily handles feedback circuits using driving point impedance dpt techniques directly generate signal graph sfg coupled pole zero diagrams complete analytical tool results giving design engineer qualitative well quantitative answers simple extrapolation methodology shows applicable systems composed linear cells active filters loading effects input output ports automatically included analysis
study new versatile active element namely multifunction current differencing cascaded transconductance amplifier mcdcta proposed device adopts simple configuration enjoys performances low voltage low input high output impedance wide bandwidth etc simplifies design current mode analog signal processing circuit greatly especially design high order filter oscillator circuits moreover example new current mode multiphase sinusoidal oscillator mso using mcdcta described paper proposed oscillator employs one mcdcta minimum grounded passive elements easy realized provide random odd even output current signals output currents equally spaced phase high output impedance terminals oscillation condition oscillation frequency adjusted independently linearly electronically controlling bias currents mcdcta operation proposed oscillator testified pspice simulation experimental results
traditional cognitive assessment neurological conditions involving physical disability often prevented presence verbal motor impairment date extensive motor verbal free neuropsychological battery available purposes adapted set neuropsychological tests assessing language attentional abilities executive functions social cognition eye tracking control explored feasibility sample healthy participants thirty healthy subjects performed neuropsychological assessment using based neuropsychological battery together standard paper pencil cognitive measures frontal frontal assessment battery fab working memory abilities digit sequencing task global cognitive efficiency montreal cognitive assessment moca psychological measures anxiety state trait anxiety inventory stai depression beck depression inventory bdi also collected usability questionnaire administered significant correlations observed paper pencil screening working memory abilities based neuropsychological measures based battery also correlated moca poor correlations observed fab usability aspects found influenced working memory abilities psychological components based neuropsychological battery developed could provide extensive assessment cognitive functions allowing participants perform tasks independently integrity motor verbal channels studies aimed investigating validity usability components neurological populations motor verbal impairments
gastroesophageal reflux disease gerd common condition substantial impact quality life patients leading risk factor esophageal adenocarcinoma therapy proton pump inhibitors ppis basic method treatment patients gerd however one third patients respond therapy used causes refractory gerd fairly large group heterogeneous factors contributing inefficacy ppis adequate dosage among factors low compliance patients prescribed treatment regimen nocturnal acid breakthrough cypc gene polymorphism chiasm syndrome functional diseases gastrointestinal tract non acidic refluxes patient thoracic esophageal motility disorders increased number duration transient lower esophageal sphincter relaxation periods hiatus hernia misdiagnosis hour impedance high resolution esophageal manometry informative diagnostic techniques patients fail respond ppi therapy techniques allow one timely recognize causes refractory gerd make differential diagnosis nosological entities timely correct therapy individual patient
years conventional wisdom held patients asymptomatic ventricular pre excitation asymptomatic wpw wpw pattern low risk adverse outcomes assumption challenged recently number observational natural history studies well prospective trials patients aggressively studied via invasive electrophysiology study eps aggressively treated cases pre emptive catheter ablation despite lack symptoms sum data definitively support one approach early stream eps ablation watchful waiting close monitoring recent pediatric adult guidelines reflect ambiguity broad spectrum approaches endorsed
objective treating insomnia includes challenging unrealistic beliefs may contribute anxieties wakefulness study explored beliefs shape continuity healthy adult sleep different adult ages methods younger older adults depicted concept normal sleep healthy year olds plots drawn show sleep depth awakenings across night results seventy percent conceptualized healthy sleep unbroken shape year olds depicted deeper sleep year olds younger adults three quarters older adults showed healthy year olds sleep without awakenings conclusion unrealistic sleep beliefs widespread healthy sleep usually mistakenly conceptualized unbroken even older adults education awakenings part normal sleep may preventative health implications reduce sleep anxieties crown copyright published elsevier inc rights reserved
determine mindfulness meditation older adults improves cognition secondarily improves mental health physiology least mildly stressed year olds randomized week intervention waitlist control outcome measures assessed baseline months later visit primary outcome measure executive function attentional measure flanker task outcome measures included additional cognitive assessments salivary cortisol respiratory rate heart rate variability positive negative affect schedule panas center epidemiologic studies depression cesd perceived stress scale pss neuroticism extraversion openness neo personality traits health related quality life one hundred twenty eight participants completed study though visit assessments significant change primary cognitive outcome measures even statistical adjustment multiple outcomes self rated measures related negative affect stress significantly improved intervention compared waitlist group panas negative cesd pss health related quality life vitality mental health component mental health component score improved minimum clinically important difference also significant changes personality traits neuroticism changes positive affect observed group differences salivary cortisol heart rate variability moderate sized improvements self rated measures paralleled improvements cognitive function physiological measures potential explanations discrepancy stress related outcomes discussed help improve future studies
investigated whether parental expressed emotion criticism emotional overinvolvement related children emotional eating whether relationship mediated children negative urgency one hundred children aged years either healthy binge eating disorder attention deficit hyperactivity disorder completed questionnaires along parents parental criticism lesser extent parental emotional overinvolvement positively related children emotional eating relationship mediated children negative urgency exploratory analyses revealed mediating role children negative urgency relationship parental criticism children emotional eating pronounced clinical group children binge eating disorder attention deficit hyperactivity disorder almost absent healthy control group copyright john wiley sons ltd eating disorders association
maternal hypothyroidism closely associated adverse maternal foetal outcomes study aims analyse associations clinical classification hypothyroidism maternal foetal outcomes evaluate effects levothyroxine supplemental replacement treatment maternal foetal outcomes pregnant women subclinical hypothyroidism sch overt hypothyroidism totally pregnant women enrolled study categorized three groups euthyroid sch group results showed pregnant women sch higher free thyroid stimulating hormone tsh levels pregnant women lower levels higher tsh levels rate premature delivery euthyroid women sch women women respectively among sch women one woman received treatment pregnancy premature delivery non treated sch women women premature delivery importantly among women women received treatment pregnancy none treated women premature delivery non treated pregnant women premature delivery data suggested therapeutic effect substitutive treatment significantly associated different clinical classifications hypothyroidism pregnancy treatment begin soon possible diagnosis
role boolean functions prominent several areas including cryptography sequences coding theory therefore various methods construction boolean functions desired properties direct interest new motivations role boolean functions cryptography attendant new properties emerged years still many combinations design criteria left unexplored matter evolutionary computation play distinct role article concentrates two scenarios use boolean functions cryptography first uses boolean functions source nonlinearity filter combiner generators although relatively well explored using evolutionary algorithms still presents interesting goal terms practical sizes boolean functions second scenario appeared rather recently objective find boolean functions various orders correlation immunity minimal hamming weight scenarios see evolutionary algorithms able find high quality solutions genetic programming performs best
paper provides information placing geosynthetic clay liner gcl lining material coarse grained soils cover systems irrigation ponds effects hydraulic head acting gcl void size subgrade material deformation behavior gcl analyzed using finite element method fem relation deformations failure gcl established comparing results obtained experimental study based upon results recommendations use gcl barrier coarse materials given
purpose purpose article review discuss varied ways computer programming introduced schools families new form learning paper examines rhetoric around coding within academic journals popular media articles past three decades article argues despite best intentions media researchers enthusiasts rhetoric around computer science schools become reality first needs greater focus monitoring rhetoric better understanding exactly programming presented wider public design methodology approach paper represents analysis peer reviewed books journal articles well news articles editorials related students learning needing learn computer programming level terms criteria inclusion addition publication date article readership three considerations article needed focus grade levels article needed focus introductory computer programming initiatives rather advanced courses topics article needed specifically focus school based learning environments findings findings point three distinct ways introductory coding initiatives portrayed perceived new literacy grounded math technical skill ultimately paper propose single defining metaphor rather argues metaphors one selects matter considerably determining programming future entering entering schools educators need make conscientious effort consider multiple metaphors without choosing one research limitations implications terms research limitations article purport exhaustive analysis metaphors used introduce schools past years rather identifies leading metaphors literature makes important first step examining role metaphor presentation new course study practical implications article intended educators researchers administrators gain better understanding could schooling social implications article intended educators researchers administrators likewise understand present students families potential course study originality value currently considerable discussion teaching high schools middle schools even elementary schools however little examination past attempts bring schools attempts may inform current advocacy
novel normalized least mean square nlms based algorithm proposed locate active taps unknown impulse response application network echo cancellation starting full length unknown echo path start tap end tap estimates active region adapt respectively form fractional tap effective tap length estimate defined length start tap end tap estimates filter tap weight vector updated effective tap length estimate following nlms algorithm tap weights located beyond effective tap length estimate directly set zero case active region unknown echo path shifts large scale start tap end tap estimates reset full length effective tap length estimate lower predetermined threshold value simulation results demonstrate proposed fractional tap based algorithm efficiently locate track effective tap length unknown echo path active coefficients change abruptly locations magnitudes outperforming existing stochastic tap based schemes
background candida pneumonia life threatening biomarker measurements early detect suspected candida pneumonia lacking study compared diagnostic values measuring levels beta glucan endotracheal aspirate bronchoalveolar lavage fluid serum detect suspected candida pneumonia immunocompromised critically ill patients methods prospective observational study enrolled immunocompromised critically ill ventilated patients suspected fungal pneumonia mixed intensive care units november october patients glucan confounding factors fungal infection excluded endotracheal aspirate bronchoalveolar lavage fluid serum collected patient perform fungal smear culture glucan assay results screening patients patients completed study categorized non candida pneumonia non candidemia suspected candida pneumonia non candida pneumonia candidemia groups glucan levels endotracheal aspirate bronchoalveolar lavage highest suspected candida pneumonia serum glucan level highest non candida pneumonia candidemia patients glucan value endotracheal aspirate positively correlated bronchoalveolar lavage fluid detection suspected candida pneumonia predictive performance sensitivity specificity glucan cutoff glucan endotracheal aspirate bronchoalveolar lavage fluid respectively accounting areas receiver operating characteristic curve respectively measuring serum glucan diagnostic value area curve detection suspected candida pneumonia absence concurrent candidemia conclusions glucan levels endotracheal aspirate bronchoalveolar lavage serum provide good diagnostic values detect suspected candida pneumonia serve potential biomarkers early detection patient population
help specialist clinicians often sought advise staff residential nursing care homes work people dementia whose behaviour challenging newcastle model james framework process developed help care staff understand improve care group model emphasises use sharing information staff develop effective care plans shared formulation sessions characteristic newcastle model clinicians take role group facilitator helping staff reach consensus needs change sessions difficult manage intra inter group processes emerge group express anxieties paper aims explore processes might play shared formulation sessions suggest ways facilitator might approach manage effective collaborative working
electrified powertrains propulsion systems gained significant interest transport industry develop energy efficient vehicular systems powertrains rechargeable energy storage systems high energy batteries electrochemical double layer capacitors high power batteries electric motors energy management strategies advanced power electronics converters play important role development new generations clean vehicles therefore paper proposes new drivetrain architectures straddle truck carriers one highway vehicles used harbors move containers order improve straddle truck carriers drivetrain efficiency reduce greenhouse emissions well energy bills proposed drivetrains series hybrid straddle truck carrier based small rechargeable energy storage system option series hybrid based reduced internal combustion engine option full electric drivetrain new full electric drivetrain based dynamic wireless power transfer system paper accurate quasi static model conventional straddle truck carrier drivetrain developed described detail proposed drivetrain architectures designed modeled using matlab simulink article also presents optimal design rechargeable energy storage systems utilized drivetrains based rechargeable energy storage system type thorough comparative study new straddle truck carrier drivetrains described detail finally developed model simulation results validated real measurements drivetrain elsevier ltd rights reserved
study sought describe morphological changes taking place goat reticulum prenatal development using histomorphometric immunohistochemical techniques total goat embryos foetuses used first stages prenatal life birth differentiation reticulum separate compartment primitive gastric tube observed days prenatal life gestation days gestation reticular wall comprised three layers internal epithelial layer middle layer pluripotential blastemic tissue external layer serosa primary reticular crests visible days gestation evaginations epithelial stratum basale marking earliest histological differentiation future reticular cells secondary reticular crests observed days gestation corneum papillae first became apparent lateral surface primary reticular crests days gestation muscularis mucosae visible days gestation primary reticular crests neuroendocrine cells detected synaptophysin days gestation glial cell markers glial fibrillary acidic protein vimentin observed days gestation days gestation respectively peptidergic innervation markers neuropeptide vasoactive intestinal polypeptide detected days gestation conclusion prenatal development reticulum like rumen appears take place somewhat earlier goats sheep cattle similar rate reported deer
background infrapatellar fat pad ipfp implicated possible source osteoarthritis development knee pain due production inflammatory mediators existence nerve fibers within structure calcitonin gene related peptide cgrp vasodilatory neuropeptide localized joint tissues recently implicated development knee pain date however expression levels cgrp ipfp human knee patients examined methods iffp synovial syn tissues harvested individuals radiographic knee unilateral kellgren lawrence grades total knee arthroplasty subjected immunohistochemical analysis cgrp localization addition messenger rna mrna expression levels cgrp cyclooxygenase cox collected tissues evaluated compared using real time pcr analysis total rna extracts cgrp cox mrna expression also compared among individuals grades results cgrp positive cells detected capillaries within ipfp lining layer syn tissue expression levels cgrp ipfp positively correlated cox significantly higher syn tissue cgrp expression tissue group twofold higher group conclusions ipfp knee patients produces relatively high levels cgrp may regulated cox transcriptional level studies needed determine cgrp levels directly linked pathology
unique depth scientific knowledge allowed ferrous metallurgy lead development successful computational materials design methodology grounded system fundamental databases expansion approach embrace acceleration full development qualification cycle resulted flight first fully computationally designed qualified material example ferrous alloys provides template general methodology computational design materials acta materialia inc published elsevier ltd rights reserved
study evaluated use vinasse substrate microbial biomass production disposal impact environment grown vinasse microbial biomass scp two saccharomyces cerevisiae strains ccma ccma showed high levels essential amino acids varying levels chemical elements low nucleic acid content good characteristics food supplemements following biological treatment spent vinasse biochemical oxygen demand bod chemical oxygen demand cod decreased respectively cultivation cerevisiae significantly reduced short term phytotoxicity toxicity soil microbiota spent vinasse elsevier ltd rights reserved
performed systematic review designed characterize clinical phenotypes outcomes indigenous populations rheumatic disease enhance understanding rheumatic disease presents indigenous populations allow better projection healthcare needs communities affected systematic search performed medical medline embase cinahl indigenous conference abstract databases june search terms indigenous populations combined terms inflammatory arthritis conditions connective tissue disorders crystal arthritis osteoarthritis studies included reported disease features disease activity measures patient reported outcomes canadian american australian new zealand indigenous populations data extracted duplicate narrative summary prepared total titles abstracts reviewed underwent full text review met inclusion criteria nearly studies described outcomes north american populations four studies australia four studies new zealand majority studies rheumatoid arthritis systemic lupus erythematosus indigenous patients rheumatoid arthritis higher disease activity reported significant impact patient reported outcomes quality life non indigenous patients spondyloarthropathy features described north american populations patients advanced manifestations systemic lupus erythematosus nephritis frequent indigenous populations gout osteoarthritis severe new zealand maori populations existing literature supports differences disease phenotype severity indigenous populations canada america australia new zealand encourage investigators area research undertake contemporary studies disentangle differences phenotype severity biologic etiology merely reflecting differences access care provide longitudinal assessment outcomes diverse populations
addition everyday political threats leaders risk removal office coups mass movements rebellion leaders face threats shocks downturns health country economy government revenue integrating risks selectorate theory characterize conditions threat pertinent countermoves purges democratization expansion public goods expansion private benefits best enable leader survive office model identifies new insights nature assassins relative risk different types leader removal function extant institutions government endogenous factors driving better worse public policy decisions democratize become autocratic importantly results highlight increase risk deposition via one means intensifies removal risks
subspace identification methods sims past outputs multivariable output error state space moesp numerical algorithms subspace state space system identification canonic correlation analysis build state space models set input output data linear time invariant system algorithms key step computation extended observability matrix done via orthogonal projection spaces generated input output data however moesp algorithm unlike others subspace methods uses different space computing projection fact hinders analysis direct comparison algorithms paper introduce modified version moesp algorithm conceptually simpler requires fewer steps computing model parameters enables comparison sims three numerical examples provided order show effectiveness proposed approach
currently many university programs construction field take sustainability account holistic viewpoint may cause lack sensitivity future professionals concerning sustain ability academics construction must endeavor instill culture sustainability curricula students therefore study proposes active learning method allows graduate students construction field take consideration infrastructure sustainability variety perspectives participatory process students applied analytical hierarchical process determine appraisal degree criterion cluster statistical analysis carried aiming identify profiles influence decision making method applied two classes graduate students enrolled master planning management civil engineering universitat politecnica valencia method identified correlation profiles toward sustainability characteristics chosen infrastructure also found method fulfills educational purposes students obtained target learning outcomes approach promotes awareness sensitivity different points view sustainability participatory context replicated contexts obtain appraisals regarding various criteria help enhance decision making elsevier ltd rights reserved
food allergy common health problem worldwide increasing prevalence recent decades approved treatments food allergy food avoidance administration emergency medications case accidental exposure negatively affects patients quality life new treatments highly desirable different food immunotherapy modalities recently used variable success rates induction desensitization tolerance different numbers types adverse reactions adverse reactions especially intolerable gastrointestinal symptoms important causes immunotherapy withdrawal eosinophilic esophagitis reported complication milk egg peanut oral immunotherapies sublingual immunotherapy respiratory allergies food allergies eosinophilic gastritis eosinophilic colitis also rarely happened following egg milk oral immunotherapies patients undergoing oral sublingual immunotherapies closely followed long time gastrointestinal symptoms evaluated endoscopy gastrointestinal tract complications usually reversible early diagnosis stopping immunotherapy protocol karger basel
background tumor necrosis factor alpha tnf alpha inhibitor etanercept proven effective treatment ankylosing spondylitis genetic polymorphism may affect drug metabolism drug receptor resulting interindividual variability drug disposition efficacy purpose study investigate correlations cypc cypd cypa gene polymorphisms efficacy etanercept treatment patients methods march june patients males females mean age years years old enrolled study polymerase chain reaction restriction fragment length polymorphism applied detect allele genotype frequencies cypc cypd cypa gene polymorphisms joint swelling score erythrocyte sedimentation rate esr reactive protein crp level patients compared week etanercept treatment assessment ankylosing spondylitis asas bath ankylosing spondylitis disease activity index basdai scores recorded assess efficacy etanercept treatment results patients wild type heterozygous genotypes cypc polymorphism accounted respectively without genotype patients wild type heterozygous mutation homozygous genotypes cypd polymorphism accounted respectively patients wild type heterozygous mutation homozygous genotypes cypa polymorphism accounted respectively week treatment patients wild type genotype cypc genotype cypd genotype cypa polymorphisms lower joint swelling score esr crp level joint swelling score esr crp levels significantly lower patients genotype cypd polymorphism genotype patients lower patients genotype cypa polymorphism compared genotypes average visual analog scale scores asas indexes decreased treatment patients genotype cypd polymorphism genotype cypa polymorphism exhibited higher scores asas basdai effective rate conclusion results indicate genotype cypd polymorphism genotype cypa polymorphism correlated efficacy etanercept treatment patients
relation child abuse child neglect understudied even though common causes least much harm child maltreatment single category linked substance use disorders sud child abuse alone without neglect linked sud remains unclear whether differences exist link sud child abuse alone without neglect versus sud child neglect alone without abuse utilising national survey child adolescent well nscaw wave wave months later used logistic regression longitudinally assess whether past year abuse versus past year neglect wave equally influential predicting newly diagnosed substance dependence wave among youth without sud wave adjusting several factors found past year child neglect wave significant predictor newly diagnosed substance dependence wave among youth sud wave forms youth maltreatment unrelated findings suggest child welfare substance abuse professionals could pay special attention youth past year neglect order help prevent emergence new substance dependence disorders copyright john wiley sons ltd
address resolution protocol arp important protocol data link layers aims obtain corresponding relationship internet protocol media access control mac addresses traditional arps address resolution neighbor discovery protocols consider existence malicious nodes reveals destination addresses resolution process thus traditional protocols allow malicious nodes easily carry attacks man middle attack denial service attack overcome weaknesses propose anonymous address resolution protocol publicize destination address address resolution process hides mac addresses source node malicious node obtain addresses destination node initiates address resolution thus attack analyses experiments show higher security level existing security methods secure neighbor discovery
work addresses influence soil confinement creep behavior geotextiles presenting results full scale field test two samples nonwoven polypropylene geotextile inserted different depths high compacted sand fill samples loaded constant tensile load period maintain constant load test system weights pulleys load cells used sand fill samples instrumented several types transducers order measure strains displacements applied forces soil stresses temperature direct shear inclined plane tests conducted measure mechanical properties interfaces interpretive model proposed analyze field results confined creep behavior field compared results obtained authors isolation creep results obtained laboratory tests elsevier ltd rights reserved
paper describes design fabrication element transducer array airborne ultrasonic imaging operating khz operate close range near field synthetic aperture proposed imaging technique based modified version delay sum algorithm implemented synthetic aperture pixel amplitude determined integration signal obtained coherent summation acquired signals delayed window fixed length image reconstruction methods using raw data provides possibility detect targets smaller feature size order one wavelength coherent signals summation selected window length image reconstruction methods using summation enveloped signals increases amplitude response expenses lower spatial resolution implementation system important design compact airborne transducers large field view obtained new design hemi cylindrical polyvinylidene fluoride film transducers directly mounted printed circuit board new method low cost repeatable transducer characteristics complete system compact modular architecture eight boards dual ultrasonic channels mounted mother board daughter board hosts microcontroller unit operate transducers bandwidth khz board data acquisition pre processing transfer dedicated bus
paper new tool simultaneous optimisation decisions multiple time scales presented tool combines dynamic properties markov decision processes flexible compact state space representation limited memory influence diagrams limids temporal version limids temlimids defined adding time related functions utility nodes result expected discounted utility well expected relative utility might used optimisation criteria temlimids optimisation proceeds ordinary limids sequence temlimids used model markov limid process temlimid represents macro action algorithms presented find optimal plans sequence macro actions use algorithms illustrated based extended version example pig production originally used introduce limid concept
paper presents general agent based system identification framework potential solution data driven models building systems developed integrated improved efficiency flexibility scalability compared centralized approaches proposed method introduces building sub system agents optimized independently solving locally maximum likelihood estimation problem several models considered sub system agents systematic selection approach established considering root mean square error parameter sensitivity output trajectory parameter correlation final model integrated selected models agent two different approaches developed integration negotiated shared parameter model distributed method free shared parameter model based decentralized method results case study high performance building indicate model prediction accuracy new approach fairly good implementation predictive control
adolescent sexual development across board seen normative well risky behavior depending factors age onset number partners longitudinal study identified developmental trajectories annual number sexual partners adolescence emerging adulthood antecedents ages participants females annually reported number sexual partners measures adolescent family characteristics taken ages used predictors group based modeling identified four trajectory groups abstainers group low increasing group medium increasing group multiple partners group multinomial logistical regressions indicated better social competence increased chances belonging multiple partners group compared abstainers low increasing groups substance use predicted membership multiple partners group compared abstainers group moreover females overrepresented low increasing medium increasing groups results imply greater diversity sexual development proposed literature highlight importance identifying strengths competencies associated healthy sexual development along early risk factors
popularity indoor tanning may partly attributed addictive characteristics tanning individuals aimed determine association frequent indoor tanning view surrogate tanning addiction food addiction total women included nurses health study collected information indoor tanning high school college age years calculated average use indoor tanning periods food addiction defined clinically significant symptoms plus clinically significant impairment distress assessed using modified version yale food addiction scale totally participants reported indoor tanning high school college age years total women met criteria food addiction observed dose response relationship frequency indoor tanning likelihood food addiction trend independent depression bmi confounders compared never indoor tanners odds ratio confidence interval food addiction average indoor tanning times year times year times year times year times year frequent indoor tanning early adulthood associated prevalence food addiction middle age data support addictive property frequent indoor tanning may guide intervention strategies curb indoor tanning prevent skin cancer
graphs powerful versatile data structures used represent wide range different types information article introduce method analyze visualize important class data described graphnamely ensembles paths analysis path ensembles useful variety applications diverse fields transportation computer networks molecular dynamics proposed method generalizes concept band depth ensemble paths graph provides center outward ordering paths ordering turn used construct generalization conventional boxplot whisker plot called path boxplot applies paths graph utility path boxplot demonstrated several examples path ensembles including paths defined computer networks roads supplementary materials article available online
purpose purpose paper validate list key indicators kis team integration identified construction management literature identify significant kis provide suggestions influence team integration based opinion established construction peer group new zealand design methodology approach literature review conducted identify consolidate set kis team integration subsequently set questions designed gain insight opinion terms significance ranking identified indicators well suggestions influence integration practice findings analysis survey results showed relevant indicators strong influence towards determining success team integration construction projects top ranked indicators contribute towards successful team integration relationship orientated follows single team focus goals objectives trust respect commitment top management free flow communication blame culture framework influencing indicators team integration proposed includes four elements first team formation second contractual model third teamwork principle fourth operational monitoring research limitations implications findings limited practitioners perceptions registered established construction peer group new zealand practical implications results study expected provide insight construction practitioners help embrace team integration practice hence provide opportunity platform enhance measure team performance originality value paper recognises process integration result combination many indicators extends team integration literature providing insights dominant relationship indicators team integration influence indicators based proposed framework
objectiveit unclear whether observed memory impairment anorexia nervosa depends semantic structure categorized words material encoded aimed investigate processing semantically related information methodmemory performance assessed recall learning recognition test adult women restricting binge eating purging subtype average disease duration years healthy controls using extended version rey auditory verbal learning test applying semantically related unrelated word stimuli resultsshort term memory immediate recall learning regardless semantics words significantly worse patients whereas long term memory delayed recall recognition differ patients controls discussionsemantics stimuli better effect memory recall compared impaired short term versus long term memory discussed relation dysfunctional working memory copyright john wiley sons ltd eating disorders association
date reports described potential factors influencing position conus medullaris one previous study revealed significant change conus locations patients idiopathic scoliosis however effect ankylosing spondylitis related thoracolumbar kyphosis conus position remains unexplored therefore aimed investigate variation conus medullaris terminations patients thoracolumbar kyphosis secondary compared normal subjects evaluated relationship conus positions magnitude kyphosis study images patients thoracolumbar kyphosis including males females average years range years age matched normal controls reviewed determine conus terminations relation spinal levels sagittal parameters group measured radiograph included global kyphosis thoracic kyphosis lumbar lordosis thoracolumbar junction tlj finally conus tips located mean level lower groups significant difference conus distributions control group addition conus medullaris displayed similar positions patients among various apical region groups significant difference found population stratified ranges degrees also remarkable correlation conus positions tlj identified study showed conus terminations displayed wide range distributions patients thoracolumbar kyphosis similar normal subjects moreover conus located relatively fixed position would affected change kyphosis magnitude important knowledge surgeons acquire surgical correction deformity patients
case relatively traditional society like india one hand gender roles strongly enforced hand continuous feminization workforce result liberalization global policies early still present binary definition gender confining men productive space relegating women domestic sphere entrance women labor force implies entrance women public urban space paper challenges spatial separation industry urban life city current context landscape industries changing manufacturing service relationship urban morphology industry gendering paid work illustrated indian context case study two industries bangalore highlights unique challenges women participating workforce paper explores another urban model possible responding better women needs
purpose study determine whether emerging adults use relationship television form expectations sexual interaction romantic relationships considering emerging adulthood unique period development providing opportunities experiment adult identities relationship television contains multiple consistent messages gender roles sexual relationships questioned whether emerging adults relationship television viewing may related sexual expectations relationships findings indicated women relationship television viewing associated expecting sexual interaction relationship men sexual expectations moderated perceived realism men watched relationship television perceived television less realistic reported expecting less frequent sexual interaction
weibull distribution used describe scaling strength materials verified wide range materials geometries however quality fitting tended less good towards upper tail based previously developed probabilistic strength prediction method adhesively bonded joints composed pultruded glass fiber reinforced polymer gfrp adherends verified two parameter weibull probabilistic distribution able model accurately upper tail material strength distribution different improved probabilistic distributions compared enhance quality strength predictions following probabilistic distributions examined two parameter weibull reference fold weibull grafted distribution birnbaum saunders distribution generalized lambda distribution generalized lambda distribution turned best analytical approximation strength data providing good fit experimental data leading accurate joint strength predictions original two parameter weibull distribution found proper modeling upper tail leads noticeable increase quality predictions elsevier ltd rights reserved
sublingual immunotherapy slit relies high doses allergens treat patients type allergies although slit commonly performed without adjuvant delivery system allergen could formulated allergen presentation platforms better target oral dendritic cells eliciting regulatory immune responses improving availability allergens immune system enhance slit efficacy allowing decrease allergen dosing herein present overview adjuvants vector systems could considered candidate allergen presentation platforms sublingual route platforms encompass adjuvants capable stimulating allergen specific regulatory cell responses including dihydroxy vitamin glucocorticoids toll like receptor ligands well selected bacterial probiotic strains limiting factor slit efficacy number dendritic cells capturing allergens upper layers oral tissues thus adsorption encapsulation allergen within mucoadhesive particulate vector delivery systems also potential significantly enhance slit efficacy due facilitated allergen uptake tolerogenic oral dendritic cells american academy allergy asthma immunology allergy clin immunol pract
accurate timely information construction project progress regular repeated basis one critical stages construction management purpose study investigate impact field data capturing technologies fdct combination building information modelling bim automated construction project progress monitoring acppm research based survey contracting engineering consulting firms operating middle east mid asia europe north america far east based evaluation findings laser scanning image based radio frequency identification rfid technologies combination bim found used technologies acppm end conceptual framework illustrated managerial implications highlighted sample statement focusing requirements processes benefits study confirms importance using bim based fdct enhancing acppm factors performance authors published elsevier ltd
metaiodobenzylguanidine cardiac scintigraphy mibg useful imaging technique diagnosis dementia lewy bodies dlb however mibg serious disadvantage demands long examination time objective study evaluate statistically usefulness heart mediastinum ratio early phase mibg differential diagnosis dlb total patients examined including non dlb alzheimer dementia dlb patients mean early ratio non dlb group dlb group mean delayed ratio non dlb group dlb group cutoff point early images sensitivity specificity diagnostic accuracy respectively area curve indicating moderate accuracy analysis indicates images early phase mibg alone sufficient differential diagnosis alzheimer disease dlb
image enhancement plays crucial role many image processing applications aims improving visual informational quality distorted images histogram equalization one frequently used techniques image contrast enhancement however histogram enhancement approaches may yield natural looking artifacts enhancement images computed methods desirable applications consumer electronic products brightness preservation necessary avoid annoying artifacts overcome problems new optimal grey level mapping based edge preserved satellite images enhancement technique using beta differential evolution bde algorithm proposed paper proposed method uses simple grey level mapping technique beta differential evolution algorithm together corresponding enhancement operators quality contrast brightness boosting satellite images approach grey levels input image replaced new set grey levels proposed algorithm tested numerous colored satellite images also standard lena image qualitative statistical comparisons proposed bde artificial bee colony modified artificial bee colony particle swarm optimization differential evolution algorithms presented paper proven superiority terms psnr mse ssim fsim eki indices
menisci knees semicircular fibrocartilaginous structures consisting hydrophilic extracellular matrix containing network collagen fibers glycoproteins proteoglycans maintained cellular component menisci responsible load transmission across knee increase joint congruity thereby also aiding fluid film lubrication joint united kingdom meniscal tears common form intra articular knee injury one commonest indications orthopedic intervention management injuries dependent location within meniscus relative peripheral blood supply pattern tear removal meniscus known place knee increased risk osteoarthritis therefore repair meniscal tears preferable however significant proportion tears irreparable treated partial even complete meniscectomy recent studies shown encouraging results meniscal replacement situation though work required area
paper introduces smart assistant professional volleyball training based machine learning techniques saeta saeta addresses two main aspects elite sports coaching technical tactical effort control aims controlling exercise effort fatigue levels exercise quality training complements former analyzing execution player movements saeta relies sensing infrastructure monitors players environment produces real time data analyzed different modules decision engine technical tactical effort control based dynamic programming model selects best activity rest durations interval training goal maximizing effort preventing fatigue exercise quality control consists two stages first stage movements detected means nearest neighbors classifier second stage movement intensity classified according recent statistical data player analyzed analyses reported coaches players real time saeta developed close collaboration universidad catolica san antonio murcia volleyball team competes spanish women premier league data gathered training sessions provided knowledge base algorithms developed used validation results
analysis application single stage partial admission axial turbine organic rankine cycle presented cycle utilized recover heat rejected internal combustion engine selected fluid rfa whose real gas behavior relevant studied conditions modeled redlich kwong soave equation state loss model flow axial blades proposed work based boundary layer theory concept diffusion factor wind tunnel cascade tests available literature conservation equations compressible flow basic geometry dimensions needed achieve maximum turbine efficiency determined several subcritical supercritical cycle conditions means restrained design optimization algorithm single stage turbine preliminary design shown greatly influenced media compressibility use convergent divergent profiled nozzles promising achieve highest possible performance potential especially high evaporator pressure conditions elsevier ltd rights reserved
recent past many smart materials based structural health monitoring shm technique attracted academics industries carry health inspection bridges underground structures many civil infrastructures applications smart material piezoelectric transducer pzt due ability sense defects engineering structures actuated presence electric field improving rapidly final year project describes one advancement enhance pzt based shm electromechanical impedance emi technique monitor structural performance engineered cementitious composites ecc specimens principal methodology record admittance signatures obtained actuation pzt transducer attached ecc specimens qualitative changes admittance signatures imply subsequent disturbances specimens research demonstrates adoptions commonly used surface bonded pzt transducer newly developed nut bolt pzt assembly experimental signatures recorded surface bonded nut bolt pzt assemblies addition resulted admittance signatures compared numerically simulated signatures
recently completed aizhai bridge west hunan province china long span suspension bridge across deep canyon view particular problems posed surrounding landscape geologic conditions minimize impact bridge natural environment novel pylon girder detached suspension structure adopted large difference span main cable stiffening girder part design process method stability analysis combined system pylon anchorage tunnel rock cliff developed addition solve problems involved transportation erection stiffening girder long span suspension bridge mountainous area novel girder conveying track cable method developed american society civil engineers
hereditary angioedema attacks rare emergency care providers must aware clinical presentation treatment patients emergency department remains common setting patients seek treatment providers aware past medical history patients likely receive standard therapies respiratory distress anaphylaxis including antihistamines corticosteroids epinephrine however medications may work patients given pathophysiology underlying disease since several new therapies approved treatment acute hereditary angioedema attacks article discusses pathophysiology clinical presentation use novel therapies management angioedema
complex structure relational data makes process knowledge discovery data challenging task compared single table data structure usefulness granular computing based approaches mining data stored single table driving force adapting method relational data paper proposes relation based granules defined granular computing based approach mining relational data relations used represent relational data patterns discovered thanks representation generation patterns speeded representation also makes possible discover richer knowledge relational data elsevier rights reserved
paper problem control algorithm design class nonlinear two input two output tito networked control systems ncss non gaussian random time delays investigated general non linear auto regressive moving average exogenous model used describe plant due non gaussian random time delays involved systems insufficient obtain satisfactory optimal control algorithm controlling expected value tracking errors renyi entropies tracking errors control inputs adopted characterize randomness closed loop system formulations probability density functions pdfs tracking errors control inputs deduced minimizing new performance index recursive optimal control algorithm obtained furthermore local stability condition closed loop systems established finally simulation results presented illustrate effectiveness proposed method
background tens millions seniors risk herpes zoster complications live attenuated herpes zoster vaccine hzv reduces risk although questions regarding effectiveness durability protection routine clinical practice remain used medicare data investigate hzv effectiveness durability methods retrospective cohort study included beneficiaries ages years january july multiple adjustments account potential bias made hzv vaccinated beneficiaries matched unvaccinated beneficiaries primary analysis hzv unvaccinated beneficiaries received pneumococcal vaccination secondary analysis outcomes community hospital settings analyzed including ophthalmic zoster postherpetic neuralgia phn results among eligible beneficiaries average age years primary analysis found community first subsequent years postvaccination respectively secondary analysis respectively primary analysis phn first subsequent years respectively hospitalized respectively differences age group significant conclusions primary secondary analyses hzv provided protection across ages effectiveness declined time higher better preserved time phn associated hospitalizations community
background ankle sprains common injury collegiate sports studies examined epidemiology individual ligament injuries specifically lateral ligament complex llc ankle purpose describe epidemiology including estimated yearly national incidence llc sprains among national collegiate athletic association ncaa athletes study design descriptive epidemiology study methods injury surveillance data sports ncaa injury surveillance program ncaa isp academic years used analysis injuries included analysis diagnosis llc sprain llc sprain rates rate ratios rrs cis calculated sample national estimates annual incidence llc sprains across entire student athlete body sports also calculated results academic years llc sprains reported rate per athlete exposures aes llc sprains comprised reported collegiate sports injuries ncaa isp also estimated llc sprains occurred annually among sports sports highest llc sprain rates men basketball aes women basketball aes llc sprains occurred practices however llc sprain rate higher competitions practices also llc sprains identified recurrent injuries largest proportions recurrent llc sprains found within women basketball women outdoor track women field hockey men basketball llc sprains athlete returned play less hours athlete required days returning play including return play conclusion llc sprains commonly reported injury diagnosis among united states collegiate student athletes continued examination interventions aim reduce incidence severity recurrence llc sprains specifically women warranted
identifying similarities large datasets essential operation several applications bioinformatics pattern recognition data integration make relational database management system similarity aware core relational operators extended similarity awareness introduced database engines relational operators joins group little achieved relational set operators namely intersection difference union paper propose extend semantics relational set operators take account similarity values develop efficient query processing algorithms evaluating implement operators inside open source database system namely postgresql extending several queries tpc benchmark include predicates involve similarity based set operators perform extensive experiments demonstrate three orders magnitude speedup performance equivalent queries employ regular operators elsevier ltd rights reserved
paper presents results online survey conducted assess evolution computing architecture engineering construction aec education primary goal includes contributing understanding evolution computing architecture civil engineering construction management curricula current state computing within aec curricula respect changes implemented since evaluated paper includes comparison survey survey changes levels concentrations computer science knowledge versus computer skills curricula investigated similarities differences architecture engineering including construction management programs studied comparing data associated disciplines survey results presented useful benchmarks decision making regarding research industry collaboration understanding speed needs change aec curricula key findings study include importance computing skills coverage curricula skills changed significantly years competence students skills decreased increasing trends seen percentages computer science knowledge related courses program types levels percentage computing skills related courses percentages computer science knowledge related courses aec curricula increasing trend seen importance knowledge scientific concepts computing respondents perceptions computing education still sufficient meet demands aec industry
lpc microcontroller used monitor environmental etl parameters dedicated system designed sensors measure humidity wind speed wind direction parameters displayed data accessed using wireless module system software used graphical user interface instrumentation used measure etl parameters visakhapatnam india
work aims characterize personal exposure firefighters polycyclic aromatic hydrocarbons pahs non fire work environments fire stations assesses respective risks eighteen pahs considered usepa priority pollutants dibenzo pyrene benzo fluoranthene monitored breathing zones workers five portuguese fire stations normal shift obtained levels pahs fulfilled existent occupational exposure limits well air quality guidelines total concentrations sigma pahs range light compounds rings predominant congeners sigma pahs whereas pahs rings accounted sigma pahs fuel biomass combustions vehicular traffic emissions use lubricant oils identified main sources pahs exposure studied fire corporations incremental lifetime cancer risks recommend usepa guideline thus negligible studied subjects health based guideline level exceeded times fire corporations results thus show even non fire situations firefighters exposed pahs levels may promote adverse health outcomes therefore respective occupational exposures compounds carefully controlled elsevier rights reserved
human roseoloviruses human herpesvirus hhv hhv hhv comprise roseolovirus genus human betaherpesvirinae subfamily infections viruses implicated many diseases however challenging establish infections roseoloviruses direct drivers pathology nearly ubiquitous display species specific tropism furthermore controlled study infection hampered lack experimental models mouse roseolovirus identified herein describe virus causes severe thymic necrosis neonatal mice characterized loss cells phenotypes resemble caused previously described mouse thymic virus mtv putative herpesvirus molecularly characterized next generation sequencing infected tissue homogenates assembled contiguous genome sequence containing unique predicted open reading frames orfs many closely related herpesvirus genes moreover structure virus genome phylogenetic analysis multiple genes strongly suggested virus betaherpesvirus closely related roseoloviruses hhv hhv hhv another murine betaherpesvirus mouse cytomegalovirus mcmv named virus murine roseolovirus mrv data strongly suggest mrv mouse homolog hhv hhv hhv importance herein describe complete genome sequence novel murine herpesvirus sequence phylogenetic analyses show betaherpesvirus closely related roseoloviruses human herpesviruses data combined physiological similarities human roseoloviruses collectively suggest virus murine roseolovirus mrv first definitively described rodent roseolovirus knowledge many biological clinical ramifications roseolovirus infection humans hypothesized studies showing definitive causative relationships infection disease susceptibility lacking show mrv infects thymus causes cell depletion suggesting roseoloviruses may similar properties
road runoff pollutants widely recognized major causes receiving water pollution bioswale serves effective storm water natural purification disposal technology presents important practical value controlling runoff pollution stormwater utilization multiple bioswale cells different media designed built artificial stormwater synthesized basis investigated measured data surface runoff pollution northwest china used study purification effect bioswale runoff pollutants four aspects results show different factors significantly affect water purification process removal rate nitrogen decreases increase inflow concentration media however contrary phosphorus mostly greater blast furnace slag best removal nitrogen phosphorus heavy mental low inflow concentration correlation models purification effects total nitrogen total phosphorus cod influencing factors established using multivariate regression method nash suttcliffe simulation efficiency coefficients models greater elsevier rights reserved
order combat chronic immune disorders cids absolute necessity understand bigger picture one goes beyond insights one disease molecular cellular static level unravel bigger picture advocate integral cross disciplinary approach capable embracing complexity field paper discusses current knowledge common pathways cids including general psychosocial lifestyle factors associated immune functioning demonstrate lack depth psychosocial lifestyle factors current research cohorts importantly need encompassing analysis factors second part paper discusses challenges understanding immune system dynamics effectively integrating key perspectives immune functioning including patient perspective paper suggests use techniques complex systems science describing simulating healthy deviating behavior immune system biopsychosocial surroundings patient perspective data suggested generated using specific narrative techniques conclude gain insight behavior whole system acquire new ways combatting cids need construct apply new techniques field computational complexity science even wider variety dynamic data used today systems medicine
hereditary angioedema hae rare autosomal dominant disorder due inhibitor deficiency causes episodic swellings subcutaneous tissues bowel walls upper airways disabling potentially life threatening evaluated patients confirmed hae diagnosis basal crisis state healthy subjects samples tested fgfb csf csf using bio plex kit data analysis performed via nonparametric spearman correlations two sets linear mixed models comparing hae subjects basal crisis states found significantly value higher values crisis states rather basal states three growth factors cytokine comparing healthy subjects versus hae patients basal state found significantly higher values hae subjects csf fgfb csf hae patients connection growth factors low grade inflammation absence attacks demonstrated constant higher amount fgfb csf respect healthy patients could indicate disease level activation maintains system tick state activate several stimuli able induce increase inflammatory mediators acute attack
aim study develop novel multifunctional nanoparticle encapsulates spion gemcitabine plga peg form multifunctional drug delivery system aim super paramagnetic iron oxide nanoparticles spions simultaneously synthesized encapsulated gemcitabine gem plga peg copolymers via double emulsification method optimum size encapsulation efficiency radiosensitization hyperthermia diagnostic applications considered preparation parameters systematically investigated physicochemical characteristics optimized nanoparticle studied spion plga plga gem nanoparticles prepared optimized parameters toxicity nanoparticles compared gemcitabine human breast cancer cell line mcf optimum preparation parameters obtained gem polymer equal spion polymer equal sucrose per polymer hydrodynamic diameters nanoparticles encapsulation efficiency adjusted gemcitabine spion vitro gemcitabine release kinetics controlled behavior enhancement ratios plga gem spion plga gem concentration nanoparticles equal gemcitabine respectively statistical difference significant value spion plga gem value plga gem compared gemcitabine conclusion successfully developed gemcitabine loaded super paramagnetic plga iron oxide multifunctional drag delivery system future work includes vitro vivo investigation radiosensitization application nanoparticles
assess risk pseudophakic cystoid macular edema pcme following cataract surgery patients allergies atopic disorders medical records consecutive eyes underwent cataract surgery retrospectively reviewed prevalence allergies atopic status development pcme patients known risk factors pcme excluded macular examination performed using spectral domain optical coherence tomography oct weeks surgery eyes one patient underwent cataract surgery one eye randomly selected odds ratios confidence intervals estimated patients enrolled series patients showed positive allergic status patients suffered atopic syndromes showed allergies atopic diseases pcme occurred eight patients allergy cohort whereas patient atopy cohort developed pcme risk pcme comparable patients allergies atopic diseases patients without allergies atopy allergy odds ratio confidence interval atopy positive status allergy atopy seem increase risk pcme therefore postoperative treatment cataract surgery modified allergic atopic patients
aim investigate association occurrences developmental defects enamel dde first permanent molars bronchodilators corticosteroid intake asthma like episodic treatment preschool age year old children methods children case group followed paediatric pulmonary unit unit allergology asthma inflammation aghia sofia children hospital athens greece used asthma drugs first years life control group consisted healthy children visited postgraduate paediatric dental clinic university athens information regarding demographic data medical history pregnancy birth weight duration breastfeeding mother smoking habits antibiotic use preschool age obtained structured questionnaire details concerning asthma drugs used extracted medical records children groups underwent oral examination standard clinical conditions surfaces first permanent molars assessed enamel defects using modified dde index chi square statistics mann whitney test spearman correlation coefficient logistic regression analysis used statistical analysis data results dde present children case group control difference two groups statistically significant estimated odds ratio among children dde case group least one hypoplastic molar loss enamel type asthma drug age treatment onset duration drug use significantly associated severity extent dde among possible influential factors gender statistical significant factor conclusions children treated asthma drugs asthma like episodes preschool age showed overall increased risk developing enamel defects first permanent molars severe hypoplastic lesions loss enamel frequent finding among affected molars
paper new meta heuristic optimization technique called interior search algorithm isa levy flight proposed applied determine optimal parameters unknown infinite impulse response iir system system identification problem isa based aesthetics commonly used interior design decoration processes isa composition phase mirror phase applied addressing nonlinear multimodal system identification problems system identification using modified isa isa based method involves faster convergence single parameter tuning require derivative information uses stochastic random search using concepts levy flight proper tuning control parameter performed order achieve balance intensification diversification phases order evaluate performance proposed method mean square error mse computation time percentage improvement considered performance measure validate performance isa based method simulations carried three benchmarked iir systems using order reduced order system genetic algorithm particle swarm optimization pso cat swarm optimization cso cuckoo search algorithm csa differential evolution using wavelet mutation dewm firefly algorithm ffa craziness based particle swarm optimization crpso harmony search algorithm opposition based harmony search ohs algorithm hybrid particle swarm optimization gravitational search algorithm hpso gsa isa also used model examples simulation results compared obtained results confirm efficiency proposed method isa published elsevier ltd rights reserved
computer laboratories limited resources south african universities battling improve students access many universities use hands approach computer laboratory access number research studies past two decades written problems presented hands approach turn two alternative approaches suggested address problems problems presented hands approach caused negative impact students performance computer programming subjects students throughput rate two alternative solutions proposed many researchers field virtual laboratories remote laboratories due many challenges prohibit students access computer laboratories well various problems presented current hands approach south african universities paper investigated opportunities presented mentioned alternative solutions investigation provided answers study research questions answers point use remote computer laboratories ideal choice resolve many current computer laboratory challenges experienced south african universities
purpose review women suspected acute coronary syndrome less likely undergo investigation receive treatment men women consistently poorer outcomes review summarises latest development cardiac biomarkers could improve diagnosis outcomes women recent findings novel high sensitivity cardiac troponin assays identified differences reference range therefore diagnostic threshold myocardial infarction men women differences present across multiple populations different ethnic backgrounds range assays use uniform threshold cardiac troponin provide equivalent prediction men women lower thresholds needed women provide comparable risk stratification summary sex differences cardiac troponin concentrations widely recognised clinical practice may contributing diagnosis myocardial infarction women discrepancies patient care outcomes
hirschsprung disease hscr congenital disorder characterized intestinal aganglionosis leading pseudoobstruction majority cases limited rectum rectosigmoid hscr variably longer segment affected hscr may show many deviations hscr retrospectively reviewed clinicopathologically confirmed total cases hscr single institution year period identify hscr cases determine deviations known features hscr eight hscr cases found aganglionosis extended terminal ileum splenic flexure hscr lacked male preponderance contrast common females associated anomalies included congenital heart disease neonatal hypothyroidism previously underreported associations clinical diagnosis hscr often delayed average age diagnosis days diagnosis often made operatively rather rectal suction biopsy histologically apart aganglionosis neural hyperplasia either absent focal compounding diagnostic difficulty although number cases study limited due rarity hscr study still highlights spectrum deviations hscr known clinicopathological features hscr
mek ong river ranked terms water discharge terms sediment load world last years delta prograded south due tremendous amount sediments deposited turned tide dominated delta wave tide dominated delta study aims completing knowledge fate sediments may stored estuarine coastal systems dispersed continental shelf slope sediment transport mekong river delta mrd coastal area studied numerical simulations using delftd model model configuration calibrated validated data collected situ periods scenarios corresponding different wave conditions derived wave climate river discharge values typical low flow flood seasons enabled quantify dispersal patterns fluvial sediments close mouths along coast sediments mostly settled estuary close mouths calm conditions suspended sediment higher concentrations extend offshore higher waves waves southeast enhanced concentration along mrd coastal zone waves south southwest induced coastal erosion higher suspended sediment concentrations front southern delta net transport towards northeast delta episodes southern southwestern waves low flow season net alongshore suspended sediment transport oriented northeastward decreases southwestern part coastal zone similar northeastern part similar
variable step incremental conductance inc cond technique photovoltaic maximum power point tracking merits good tracking accuracy fast convergence speed yet lacks simplicity implementation due mathematical division computations involved algorithm structure furthermore conventional variable step size based division module power change voltage change encounters steady state power oscillations dynamic problems especially sudden environmental changes study enhancement introduced inc cond algorithm order entirely eliminate division calculations involved structure hence algorithm implementation complexity minimised enabling utilisation low cost microcontrollers cut system cost moreover required real processing time reduced thus sampling rate improved fasten system response sudden changes regarding applied step size modified variable step size depends solely power proposed latter achieves enhanced transient performance minimal steady state power oscillations around mpp even partial shading proposed technique validation simulation work carried experimental set implemented arduino uno board based low cost atmega microcontroller employed
objective stress important component pathophysiology irritable bowel syndrome ibs long term hypothalamus pituitary adrenal hpa axis activity studied measuring hair cortisol concentrations hcc previous studies indicated dysregulated hpa axis ibs patients cortisol levels hair yet studied investigated whether hcc self reported stress differentiate ibs patients controls methods cross sectional study within swedish primary health care centers compared patients working age active ibs patients without complaints participants donated hair samples completed questionnaires including scale self reported perceived stress pss rome iii fulfilling ibs patients non ibs patients available final analyses results ibs patients significantly lower hcc median iqr compared non ibs patients median iqr also difference distribution hcc quintiles two groups ibs patients non ibs patients lowest quintile hcc pss higher among ibs patients mean total score compared controls quintiles hcc pss stayed significantly weakly related ibs std error multivariable analyses conclusion study suggests possible suppression hpa axis activity considerable portion ibs patients elsevier inc rights reserved
curcumin phenolic compound wide spectrum therapeutic effects antitumor anti inflammatory anti cancer study aimed investigate underlying mechanisms curcumin protect liver damage progression non alcoholic steatohepatitis nash novel nash hepatocellular carcinoma hcc mouse model induce model neonatal cbl male mice exposed low dose streptozotocin fed high fat diet hfd age weeks weeks curcumin given dose daily oral gavage started age weeks continued weeks along hfd feeding found curcumin improved histopathological changes nash liver via reducing level steatosis fibrosis associated decreasing serum aminotransferases addition curcumin treatment markedly reduced hepatic protein expression oxidative stress pro inflammatory cytokines chemokines including interferon ifn gamma interleuldn beta ifn gamma inducible protein nash mice furthermore curcumin treatment significantly reduced cytoplasmic translocation high mobility group box hmgb protein expression toll like receptor nuclear translocation nuclear factor kappa kappa also dramatically attenuated curcumin nash liver curcumin treatment effectively reduced progression nash hcc suppressing protein expression glypican vascular endothelial growth factor pro thrombin nash liver data suggest curcumin reduces progression nash liver damage may act via inhibiting hmgb kappa translocation elsevier rights reserved
paper presents computer aided system known deep drawing tool applied resolution combined deep drawing ironing process system allows user selecting input data getting formability material deep drawing selecting process provides best solution technological perspective optimizing process material waste knowing influence punch results considering process cost manner tool allows developing competencies students apply scientific technological mathematical economical sustainable knowledge global vision manufacturing processes conciliating research teaching industrial case considered proposed computer aided system tested brass alloy demonstrate system capability results obtained show significant improvements two variables analyzed namely total process time total manufacturing cost aspects provide competencies students manufacturing environment
positron emission tomography pet studies provided invaluable data antipsychotic effects selection bias remains serious concern systematic review pet studies measured dopamine receptor blockade antipsychotics conducted examine inclusion exclusion criteria using pubmed embase clinicaltrials gov last search september pet studies included measured receptor occupancy patients schizophrenia included introduction antipsychotic treatment antipsychotic regimen change systematic manner twenty six studies identified age limit included studies one study solely included geriatric patients others targeted younger adults eleven studies specifically targeted clinically stable patients patients severe psychopathology antipsychotic free patients respectively nineteen studies excluded patients physical comorbidity substance abuse respectively result mean age subjects ranged years one study targeted geriatric patients excluded mean positive negative syndrome scale total scores ranged comparison active drug placebo arm employed studies blind assessment symptomatology performed studies general subjects participating clinical pet studies relatively young presented mild symptomatology free substance abuse physical comorbidities characteristics need taken account clinical pet data interpreted hand also noted study qualitative conservative interpretation necessary possibility subjective bias elsevier ltd rights reserved
paper describes architecture functionality generic agent charge handling given environment ambient intelligence context ensuring suitable contextualized personalized support user actions adaptivity user peculiarities changes time automated management environment architecture implemented multi agent system different types agents endowed different levels reasoning learning capabilities addition controlling normal operations environment system may identify user needs goals activate suitable workflows satisfy actions workflow involve execution semantic services single service available fulfilling given need automatic service composer used obtain suitable combination services architecture implemented prototypical agent based system works smart home environment
expertise tends seen something people possess one needs knowledge skills competences able job well preferably better others various conditions practice objectively relevant knowledge expertise gets endorsed multi party settings different forms expertise tend compete one another latter certainly true construction sector parties different backgrounds stakes interests work together order create maintain buildings infrastructural works existing knowledge expertise need performed order get treated relevant interactional business hand people one collaborates whose expertise treated salient may differ across interaction settings make different phases project far however expertise treated relevant day day management construction projects effects thereof understudied argument put forward expertise research informed performative turn social sciences may enrich construction management research agenda performative studies tend insight expertise ends treated relevant actual practice researching various expertises discursively positioned relative one another multi party settings insight existing expertise counts may help developing strategies ensure expertise considered relevant underused practice may optimally deployed future general directions provided expertise may researched performative perspective construction
paper presents design optimization linear induction motor application linear induction motor includes various industrial processes like conveyor belt vertical movement steel power plant induction heating automated material handling applications require efficient high torque providing linear induction motor objective function optimization problem discussed paper includes efficiency output thrust machine weight various machine design parameters used constraint variables optimization done quasi newton process shows significant improvement machine efficiency output torque compared results reported literature machine design optimization carried using rmxprt software
objective assess role abdominal obesity incidence disability older adults living sao paulo brazil year period design longitudinal study part sabe study health wellbeing aging assessed disability incidence period reported difficulty least one activity daily living adl relation abdominal obesity waist circumference men women used poisson regression evaluate association obesity disability incidence adjusting sociodemographic clinical factors including bmi setting sao paulo brazil subjects older adults independent adl located interviewed results crude disability incidence least one adl person years period incidence rate two times higher participants abdominal obesity compared without person years respectively pattern observed bmi levels regression models abdominal obesity remained associated disability incidence incidence rate ratio even controlling bmi gender age low grip strength cognitive impairment physical inactivity chronic diseases conclusions abdominal obesity strong risk factor disability showing significant effect bmi thus intervention target older adults waist measure simple cost effective easily interpreted therefore used several settings identify individuals higher risk disability
study presents design performance evaluation digital control adapted llc series resonant converter operating wide input load variations proposed control design correctly incorporates wide varying power stage dynamics variable small signal gain digitally controlled oscillator thereby offering satisfactory converter performance operational conditions proposed digital controller adopts push pull mode control scheme executes control action two times one switching period minimise time delay enhance performance using experimental converter performance proposed push pull mode digital control demonstrated comparison conventional complementary mode digital control performs control action one switching period
background excessive stiffness lower limb muscles associated sports injuries therefore identification reliable measurement shear elastic modulus various ankle plantar flexion muscles required evaluate lower leg sports injuries study investigated reliable measurement shear elastic modulus ankle plantar flexion muscles different ankle positions methods twenty three healthy young men years participated study shear elastic moduli ankle plantar flexion muscles including lateral gastrocnemius medial gastrocnemius soleus peroneus longus peroneus brevis flexor hallucis longus flexor digitorum longus tibialis posterior measured using ultrasonic shear wave elastography degrees dorsiflexion results reliability shear elastic modulus measurements ankle position assessed results showed interday reliability measurements differed ankle positions reliability shear elastic modulus measurements degrees dorsiflexion higher degrees degrees conclusion results suggest measurements degrees dorsiflexion may provide reliable measurement shear elastic modulus ankle plantar flexion muscles
nuclear factor erythroid related factor nrf ubiquitous master transcription factor upregulates antioxidant response elements ares mediated expression antioxidant enzyme cytoprotective proteins activation nrf shown protective lung injury lung diverse stimuli including environmental oxidants medicinal agents pathogens activate nrf nrf translocates nucleus binds transcriptional induction bearing genes encoding antioxidantdetoxifying proteins nrf induces cellular rescue pathways oxidative pulmonary injury abnormal inflammatory immune responses apoptosis nrf antioxidant pathway shown important protection various lung injuries including acute lung injury acute respiratory distress syndrome bronchopulmonary dysplasia chronic obstructive pulmonary disease idiopathic pulmonary fibrosis asthma allergy widely examined new therapeutic targets present review explores protective role nrf lung injury therapeutic potential targeting nrf
part development whole coast strategy coastal protection gold coast queensland australia structural integrity called line seawall investigated review design wall undertaken seawall located along erosion scarps extends much length developed shoreline gold coast combination beach nourishment terminal seawalls integral part long term management gold coast beaches standard seawall design alignment adopted city early structural design change years option replacing clay shale tertiary layer geotextile status investigations aimed evaluating present condition damage modes existing seawalls long term service methods included potholing ground penetrating radar excavation peel back armour layers review found standard seawall designs conformed present standards upgrading future would required future exposure levels design conditions developed along coastline concluded upgrading completion continuous seawall required future security gold coast beachfront assets uncertainty regarding rate extent changes sea levels design wave heights staged approach practical
objectivethis study aims evaluate theory mind ability sample obese patients without binge eating disorder bed explore correlations emotional clinical assessments methodsoverall non bed threshold bed bed obese patients completed battery tests assessing social cognition eating disorder psychopathology resultsbinge eating disorder non bed threshold bed obese patients showed similar ability recognise others emotions bed obese patients exhibited deficit recognising emotions demonstrated impaired levels alexithymia interoceptive awareness depressed high positive correlations evident binging depression interoceptive awareness alexithymia conclusionsbinge eating disorder patients comparable ability understand others emotions impaired capacity understand code emotions compared non bed obese patients impairment highly correlated depression copyright john wiley sons ltd eating disorders association
addictive disorders major public health concern associated high relapse rates significant disability substantial mortality unfortunately current interventions modestly effective preclinical studies well human neuroimaging studies provided strong evidence observable behaviours characterize addiction phenotype compulsive drug consumption impaired self control behavioural inflexibility reflect underlying dysregulation malfunction specific neural circuits developments accompanied advances neuromodulation interventions invasive deep brain stimulation non invasive repetitive transcranial magnetic stimulation transcranial direct current stimulation interventions appear particularly promising may allow probe affected brain circuits addictive disorders also seem unique therapeutic applications directly target remodel impaired circuits however available literature still relatively small sparse long term safety efficacy interventions need confirmed review literature use neuromodulation addictive disorders highlight progress limitations aim suggest future directions field
purpose disordered weight management behaviors prevalent among youth recent case reports suggested behaviors might also common transgender youth studied associations gender identity disordered weight management behaviors nonprescription steroid use weight perception among transgender cisgender nontransgender high school students massachusetts methods data analyzed massachusetts youth health survey anonymous survey random sample massachusetts public high schools respondents divided three groups transgender cisgender male cisgender female fisher exact tests multivariable logistic regression models used examine unhealthy weight management behaviors past days fasting hours vomiting diet pill use laxative use nonprescription steroid use self perceived weight status analyses controlled age race ethnicity body mass index results compared cisgender males transgender adolescents higher odds fasting hours adjusted odds ratio aor confidence interval using diet pills aor taking laxatives aor transgender youth higher odds lifetime use steroids without prescription male cisgender respondents aor compared cisgender females transgender respondents higher odds perceiving healthy weight underweight overweight obese aor conclusions transgender youth disproportionately self reported unsafe weight management behaviors nonprescription steroid use compared cisgender youth clinicians aware increased risk among transgender youth research needed understand disparities inform future interventions society adolescent health medicine rights reserved
developing complex intelligent system abstracting behaviors functionalities reasoning mechanisms tedious time consuming paper present framework developing application software system based smart autonomous components collaborate developer user realize entire system inspired teachable approaches programming demonstration methods robotics end user development treat intelligent agents teachable components make system built agent serves different functionalities may prebuilt operations accomplish design objectives however agent may also equipped built social cognitive traits interact user agents order adapt operations objectives relationships others results adaptation form groups multiagent systems new aggregated components approach made tackle difficulties completely programming entire system allowing user teach components toward desired behaviors situated context application exemplify novel method cases domains human like agents virtual environment agents house caregiving
background associations vitiligo thyroid diseases reported repeatedly objective investigated associations vitiligo overt autoimmune thyroid diseases thyroid cancer using korean national health insurance claims database methods defined patients vitiligo whose records showed physician contacts vitiligo principal diagnosis also established age sex matched control group without vitiligo per vitiligo patient outcomes interest concurrent graves disease hashimoto thyroiditis patients taking relevant thyroid medications thyroid cancer results study enrolled vitiligo patients controls patients vitiligo increased risks graves disease odds ratio confidence interval hashimoto thyroiditis thyroid cancer compared controls associations consistently stronger males younger patients limitations individual clinical information available homogeneous population may limit generalizability results conclusion vitiligo significantly associated overt autoimmune thyroid diseases overt thyroid cancer
background incidence thyroid cancer increasing although explanatory causes lacking link cancer inflammation well documented unclear autoimmune thyroid diseases aimed systematically review association hashimoto thyroiditis papillary follicular medullary anaplastic thyroid carcinoma thyroid lymphoma methods pubmed ovid medline google scholar cochrane library searched inclusion criteria age years cases collectively examined incidence results identified studies subjects published countries found relative risk among papillary thyroid cancer ptc confidence intervals cis ptc among among conclusion report association ptc association found follicular medullary anaplastic thyroid cancer
ambient intelligence platform nightcare remote monitoring control overnight living environment proposed platform entirely based rfid passive technology able recognize nocturnal behaviors activities generates automatic alarms case anomalous pathological events support diagnostics results complete test real scenario presented together numerical assessment electromagnetic safety issues authors published elsevier
objectives develop validate noninvasive mobility sensor automatically continuously detect measure patient mobility icu design prospective observational study setting surgical icu academic hospital patients three hundred sixty two hours sensor color depth image data recorded curated segments containing images eight patients interventions none measurements main results three microsoft kinect sensors microsoft beijing china deployed one icu room collect continuous patient mobility data developed software automatically analyzes sensor data measure mobility assign highest level within time period characterize highest mobility level validated point mobility scale collapsed four categories nothing bed bed activity bed activity walking sensor segments noninvasive mobility sensor developed using three icu patients validated remaining segments five different patients three physicians annotated segment highest mobility level weighted kappa kappa statistic agreement automated noninvasive mobility sensor output versus manual physician annotation disagreement primarily occurred nothing bed versus bed activity categories sensor assessed movement continuously significantly sensitive motion physician annotations using discrete manual scale conclusions noninvasive mobility sensor novel feasible method automating evaluation icu patient mobility crit care med
background approximately patients underwent spinal surgeries experience moderate extreme postoperative pain gabapentin used adjunct management acute pain approximately half enhanced recovery programs meta analysis aimed illustrate efficacy safety gabapentin pain management following spinal surgery methods january systematic computer based search conducted pubmed embase web science cochrane database systematic reviews google database data patients prepared spine surgery studies compared gabapentin versus placebo retrieved primary endpoint visual analog scale vas hours hours total morphine consumption secondary outcomes complications included nausea dizziness somnolence headache pruritus urine retention vomiting testing publication bias heterogeneity studies data aggregated random effects models necessary results seven clinical studies patients gabapentin group control group ultimately included meta analysis gabapentin associated reduced pain scores hours hours corresponding reduction points points hours points points hours point vas similarly gabapentin associated reduction total morphine consumption furthermore gabapentin reduce occurrence vomiting risk ratio urine retention nnt pruritus nnt number needed treat nnt significant differences occurrence nausea dizziness somnolence headache conclusions gabapentin efficacious reduction postoperative pain total morphine consumption morphine related complications following spine surgery addition high dose gabapentin effective low dose number included studies limited studies needed verify effects gabapentin spinal surgery patients
research examines implications consumers belief karma belief universe bestows rewards right exacts punishments wrong context prosocial behavior although intuitively believing karma result greater intentions right supporting charity karmic beliefs found facilitate prosocial behavior contexts associated selfgains series experiments shows strong weak beliefs karma actually respond less favorably charitable appeals rely common marketing tools meant enhance consumer responses also cue self gains offering incentives highlighting self benefits however effects obtained donations time represent means enhance social connections donations money consistent proposition prosocial behaviors motivated self gains engender karmic rewards lower intentions right among strong karmic beliefs driven shift focused self focused attention following appeals cue self gains compared appeals results imply marketers need take account consumers karmic beliefs seeking incentivize prosocial behavior
paper construction use shared memory abstraction top asynchronous message passing system processes may commit byzantine failures abstraction consists arrays single writer multi reader atomic registers number processes registers enable byzantine tolerance recording whole history values written one distributed algorithm building shared memory abstraction first presented algorithm assumes shown necessary sufficient condition construction hence algorithm resilient optimal paper presents distributed objects built top read write shared memory abstraction cope byzantine processes illustrated objects proposed shared memory abstraction motivated fact lot problems algorithms simpler design prove correct shared memory system message passing system elsevier inc rights reserved
immune checkpoint inhibitors icis targeting ctla constitute promising class cancer treatment associated several immune related disorders review literature reporting neurological adverse events naes associated icis systematic search literature february mentioning naes patients treated icis conducted eligible studies included case reports prospective trials one case seen ward also added within clinical trials totalling patients analysed overall incidence naes anti ctla antibodies anti antibodies combination clinical spectrum neurological disorders highly heterogeneous naes grade consisted non specific symptoms headache incidence high grade naes types treatment headaches encephalopathies meningitis commonly reported respectively among case reports common naes encephalopathies meningoradiculoneuritis guillain barre like syndromes myasthenic syndromes median time naes onset weeks cases drug interruption steroids led neurological recovery even conditions steroids usually recommended guillain barre syndrome elsevier ltd rights reserved
paper reports investigation optimum design passive tuned mass damper system takes account soil structure interaction multi objective optimisation approach minimising displacement velocity acceleration structure adopted three dimensional structural models five ten storey buildings resting soils different shear wave velocities used damper parameters calculated using three different approaches first damper tuned fundamental frequency fixed base structure second approach employs modified design parameters based asce third damper optimally designed using multi objective genetic algorithm optimiser results indicate taking effects soil structure interaction account leads performance improvements damper hand maximum value displacement soil structure damper system founded soft soil reduces considerable extent using genetic algorithm approach therefore simplicity efficiency using real coded genetic algorithm method optimal design tuned mass dampers compared two approaches demonstrated
additive manufacturing technology capable building near net shaped functional parts directly computer models using unit materials powder wire additive manufacturing computer aided design offers superior geometrical flexibility near net shaping capability also significantly reduces materials waste benefits make desirable critical applications aerospace ground transportation medical confident utilization technology requires thorough understanding materials ensuring structural integrity performance requirements met exceeded study fabricated two techniques laser engineered net shaping lens electron beam melting ebm investigated critically compared samples built using various processing parameters heat treated different conditions resulted different microstructures mechanical properties characteristic microstructures determined cases room temperature tensile fatigue crack growth properties also evaluated compared different orientations respect building direction effects post heat treatments microstructure properties also studied results systematically presented discussed material process optimization structural design fatigue life prediction perspectives elsevier ltd rights reserved
hyperfine structure fitting hfs tool fit hyperfine structure spectral lines multiple velocity components hfs procedures included hfs simultaneously fit hyperfine structure transitions perform standard analysis derive column density rot hfs uses monte carlo approach fitting line parameters special attention paid derivation parameter uncertainties hfs includes procedures make use parallel computing fitting spectra data cube
earthquakes material degradations environmental factors necessitate structural health monitoring shm metal foil strain gages used shm low durability low sensitivity factors motivated researchers work cement based strain sensors study effects temperature moisture electrical resistance compressive tensile strain gage factors strain sensitivity crack sensitivity determined steel fiber reinforced cement based composite rapid increase electrical resistance degrees observed due damage occurring cement paste aggregates steel fibers moisture electrical resistance relationship investigated specimens taken cure saturated water moisture content minimum electrical resistance obtained moisture fiber fiber fiber matrix contact maximum water micro voids acting electrolyte conducting electrons variation compressive tensile strain gage factors strain sensitivities crack sensitivity investigated conducting compression split tensile notched bending tests different moisture contents highest gage factor compression test obtained optimal moisture content electrical resistance minimum tensile strain gage factor split tensile test crack sensitivity increased decreasing moisture content mechanisms moisture content electrical resistance gage factors crack sensitivity elucidated relations moisture content electrical resistance gage factors crack sensitivities presented first time study steel fiber reinforced cement based composites results important development self sensing cement based smart materials
sound image compete pass wall fritz lang create tension seen heard disconnect image sound draws attention limits visual possibilities audible
currently well understood much xylem conductance lost maize plants day conductance recovered night soil water conditions required recovery take place answer questions designed greenhouse experiment whereby two genetically dissimilar maize genotypes subjected level water stress commonly experienced field psi xylem similar mpa measured loss stem specific conductivity associated level stress well overnight recovery following three watering treatments psi soil similar mpa psi soil similar mpa psi soil similar mpa mid day leaf water potentials mpa resulted stem specific conductivity values maximal loss returning soils field capacity psi soil similar mpa overnight allowed significant recovery maximal whereas partial watering psi soil similar mpa resulted values maximal values whereas watering resulted recovery maximal psi soil similar mpa recovery facilitated generation root pressure low rates nighttime transpiration
letter present design two new high performing microstrip receiving antennas global positioning system gps layouts proposed based employment multiple feeds order improve polarization purity pattern symmetry thus leading improved accuracy system first antenna configuration consists truncated corner squared patch concentric rings miniaturized magnetic resonators order suppress surface wave contribution reduce back radiation antenna second radiator consists circular patch antenna four feeds loaded number vias order improve front back ratio full wave numerical simulations presented show effectiveness proposed design terms impedance matching polarization purity antenna gain front back ratio shape radiation pattern
fission reactor utilizing low enriched uranium cermet fuel supercritical carbon dioxide coolant designed provide electrical power manned mars base reactor designed generate mwth fifteen year operational lifetime electric output kwe core alternating rows fuel elements breeder blanket nineteen coolant channels fuel element single coolant channel breeder blanket design uses isotopic enriched based cermet fuel uranium dioxide fuelled blankets used coolant converts heat generated reactor electricity using closed brayton cycle cermet fuel used form hexagonal shaped elements coolant channels zirconium hydride neutron moderator reactor uses based control drums control safety zrc used thermal insulator ensures zrh moderator reach unacceptably high temperature coolant channels cladding tungsten prevent release fission gas fuel coolant beryllium reflectors used moderate reflect neutrons back active core active core bull eye configuration alternate fuel blanket circular rows nuclear reactor modeling neutronics depletion analysis done using mcnp neutronics analysis found maximum peaking factor would occur core used determine greatest amount thermal power core fuel elements breeder blanket would experience provided basis thermal hydraulics sought determine maximum inlet outlet temperatures could obtained also keeping reactor materials within acceptable temperature range maximizing temperatures would provide highest performance power conversion system finding coolant conditions kept section core maximum permissible temperature would ensure rest core would also remain within acceptable temperature limit simulations conducted different power levels fuel element breeder blanket would generate throughout reactor fifteen year lifecycle thermal hydraulics done using comsol multiphysics research presents viable reactor design uses materials currently tested types reactors elsevier ltd rights reserved
ever growing prevalence dementia nursing costs increasing ability live independently vanishes dem home ambient assisted living framework support independent living receiving intelligent clinical care dem home integrates variety ambient wearable sensors together sophisticated interdisciplinary methods image semantic analysis semantic web technologies owl extensively employed represent sensor observations application domain specifics well implement hybrid activity recognition problem detection complete tailored user interfaces clinicians provided accurate monitoring multiple life aspects physical activity sleep complex daily tasks clinical problems leading adaptive non pharmaceutical interventions method already validated recognition performance improvement clinical level four home pilots
self care challenging previously demonstrated motivational interviewing effective improving heart failure self care objective identify mechanisms intervention effectiveness elucidating techniques used relationship techniques changes self care methods audiotaped sessions first subsequent sessions participants transcribed verbatim coded evaluate changes self care using sequential mixed method design quantitative qualitative self care data triangulated congruence techniques used mechanisms intervention effectiveness identified qualitative data results three techniques used related improved self care reflection reframing genuine empathy affirmation humor individualized problem solving techniques stimulated openness goal setting positive self talk perceived ability overcome barriers change talk mechanisms techniques achieved desired outcomes development discrepancy self efficacy consistent principles conclusion study contributes clarifying mechanism facilitates behavioral change practice implications using discuss self care help overcome barriers engage patients goal setting behavior change elsevier ireland ltd rights reserved
beam type periodic materials high connectivity displayed unique band gap behaviors analogous locally resonant band gaps acoustic metamaterials study structurally square entrant honeycomb one highly connected lattice configuration featuring eight folded beams connected joint introduced host structure smart material tailor elastic wave propagation finite length piezoelectric patches connected negative capacitance shunting circuits arranged beam surfaces providing active adjustment via altering parameters shunting circuits characteristics band structure smart structured material investigated application finite element method conjunction bloch theorem results demonstrate variation internally resonant band gaps induced alteration piezoelectric patches positions mechanical properties precisely estimated simple heuristic models proposed according deformation characteristics standing wave modes founding could promote practical implementation highly connected honeycombs adaptive control elastic wave
objective determine aetiology headache patients seen ocular examination methods cross sectional descriptive study conducted ophthalmology department karachi medical dental college abbasi shaheed hospital karachi january december comprised patients headache patients registered non probability consecutive sampling technique predesigned proforma used collect data complete ocular examination investigations conducted along neuro ophthalmological examination data analysis done using spss results patients female male mean age years range years conditions associated headache divided ocular non ocular combined pathologies among ocular causes asthenopia amajor entity asthenopic patients presented refractive errors followed presbyopics presented complaint headache number computer users similar complaint among ocular causes headache number patients corneal ulcers glaucoma endophthalmitis among non ocular causes hypertension sinusitis migraine conclusion majority patients associate ocular causes refractive errors anterior segment pathologies
introduction low testosterone levels men associated fatigue limited physical performance reduced health related quality life hrqol however relationship never assessed patients anti neutrophil cytoplasmic antibodies anca associated vasculitides aav aim study assess prevalence androgen deficiency investigate role testosterone fatigue limited physical condition reduced hrqol men aav methods male patients aav remission included study fatigue hrqol assessed multi dimensional fatigue inventory mfi rand questionnaires results seventy male patients mean age years included scores almost subscales questionnaires significantly worse patients compared controls mean total testosterone free testosterone levels nmol pmol respectively androgen deficiency defined according endocrine society clinical practice guidelines present patients scores subscales general health perception physical functioning reduced activity significantly worse patients androgen deficiency compared patients normal androgen levels testosterone age predictors rand physical component summary multiple linear regression analysis testosterone age vasculitis damage index vdi reactive protein crp associated mfi subscale general fatigue conclusions study showed androgen deficiency present substantial number patients aav testosterone one predictors physical functioning fatigue testosterone may play role fatigue reduced physical performance hrqol male patients aav
hereditary angioedema hae autosomal dominant disease resulting deficiency inhibitor inh glycosylated serine protease inhibitor plays regulatory role complement system contact system intrinsic coagulation cascade hae disease severity highly variable may influenced genetic polymorphisms well factors gender hormone mediated effects hae potential inadequate clearance immune complexes presence reduced levels components turn excess tissues results inflammatory damage release autoantigens may trigger autoimmune response occasional reports link hae autoimmune conditions studies conducted large patient populations controversial results although several immunoregulatory disorders documented prevalence defined autoimmune diseases patients hae remains debated occurrence autoimmune conditions hae patients may worsen disease severity enhancing complexity comprehensive care elsevier rights reserved
introduction muscle strength lower limbs one main components required specific actions practice side football levels insufficient elevated bilateral imbalances marked difference agonist antagonist ratio aar factors contribute development musculoskeletal injuries objective purpose study assess levels peak torque bilateral difference force production conventional ratio flexor extensor musculature knee different speeds methods study included visually impaired athletes athletes underwent anthropometric measurements determine body composition underwent evaluation isokinetic dynamometer measure levels muscle imbalance conventional ratio results concentric movements flexor muscles significant differences observed peak torque dominant limb non dominant limb ndl degrees degrees peak torque standardized pts degrees degrees extensor muscles aar significant difference ndl acceptable levels aar legs according proposed conventional football conclusion expected results study may contribute processes prevention training rehabilitation athletes side football also serve parameters future studies
background objective sarcomas rare highly aggressive tumors local recurrence surgical excision occur cases therefore strong clinical need accurate tissue differentiation margin assessment reduce incomplete resection local recurrence purpose study investigate use optical coherence tomography oct novel image texture based processing algorithm differentiate sarcoma muscle adipose tissue study design methods study tumor margin delineation feline canine veterinary patients achieved intraoperative oct help validate tumor resection differentiation lower scattering adipose tissue higher scattering muscle tumor tissue relatively straightforward challenging distinguish dense highly scattering muscle tumor tissue types based scattering intensity microstructural features alone improve tissue type differentiation objective automated manner three descriptive statistical metrics namely coefficient variation standard deviation std range implemented custom algorithm applied oct images results oct images collected intraoperatively sites vivo tissue specimens removed sarcoma surgeries following generation initial set oct images correlated standard hematoxylin eosin stained histopathology images subsequently used automated analysis using texture based image processing metrics oct images sarcoma muscle adipose tissue found statistically different one another conclusion results demonstrate potential using intraoperative oct along automated tissue differentiation algorithm guidance tool soft tissue sarcoma margin delineation operating room wiley periodicals inc
background psychological literature suggests therapist perfectionism common potentially detrimental client recovery little known relationship therapist perfectionism client outcomes aims study aimed measure perfectionism high intensity cognitive behavioural therapists establish relationships dimensions therapist perfectionism client outcomes drop rates treatment method thirty six therapists took part study levels perfectionism measured using self report questionnaire analysed relation clinical outcomes sample clients results results indicated therapist perfectionism may less common previously suggested overall number significant negative associations observed aspects therapist perfectionism high standards others treatment efficacy client retention treatment conclusions therapist perfectionism associated cbt treatment outcomes tentative recommendations therapists managing schema part clinical practice made although investigation required
funded national science foundation university nebraska lincoln spent last eight years developing implementing comprehensive educational robotics program youth ages program delivered informal school learning environments robotics camps clubs competitions provided robotics experiences youth educators goal project positively impact youths science technology engineering mathematics stem knowledge attitudes foster interest stem careers results extensive research evaluation showed youth participation robotics activities increased stem content knowledge particularly engineering computer programming perceived problem solving skills interest engineering careers youth also perceived robotics activities different school reporting robotics camp interesting involved hands activities elsevier rights reserved
background nonverbal communication critical feature successful social interaction interpersonal rapport social exclusion feature schizophrenia experimental study investigated undisclosed presence patient schizophrenia interaction changes nonverbal communication speaker gesture listener nodding method motion capture techniques recorded patient patient healthy participants control healthy participants interactions participants rated experience rapport interacting partner patients symptoms social cognition executive functioning assessed four hypotheses tested compared controls patients display less speaking gestures listener nods patients increased symptom severity poorer social cognition associated patients reduced gesture nods patients partners compensate patients reduced nonverbal behavior gesturing speaking nodding listening patients reduced nonverbal behavior increased symptom severity poorer social cognition associated others experiencing poorer rapport patient results patients gestured less speaking patients negative symptoms nodded less listeners partners appeared compensate gesturing speakers patients negative symptoms also gestured speaking alongside increased negative symptoms poorer social cognition associated others experiencing poorer patient rapport conclusions patients symptoms associated nonverbal behavior patients partners patients increased negative symptoms gesture use associated poorer interpersonal rapport study provides specific evidence negative symptoms impact patients social interactions
three gorges project consisted flood control engineering resettlement engineering transportation engineering electricity generation engineering culture engineering forth comprehensive water control project three gorges project unity tangible culture human spirits indicating high degree integration naturalism humanism rich culture theoretical summary research perspective culturology three gorges project culture includes flood control culture contending scientific verification culture migration culture construction culture township city culture transportation culture ecological culture corporation culture film television art culture national image culture institutional culture tourism culture education culture complexity three gorges project determines dual characteristics contains positive influence negative impact cultural connotation three gorges project symbolization china perseverance china rise greatly influences national merits makes surge relevant culture research philosophy mediation one day three gorges project added national cultural heritage list world cultural heritage list like dujiangyan irrigation system grand canal thus necessity time goes importance conducting research three gorges project found
traditionally allocation dynamic adaptation federated cyberinfrastructure resources residing across multiple domains data intensive application workflows performance quality service centric qspecs often compromising end end security requirements scientific workflows lack standardized formalization methods workflows end end security requirements diverse heterogenous domain resource security policies make inter conflict characterization application security performance requirements non trivial leads sub optimal resource allocation paper present joint security performance driven federated resource allocation adaptation scheme define characterize data intensive scientific application security specifications sspecs order aid security driven resource brokering among domains diverse security postures describe alignment technique inspired portunes algebra combine domain specific resource policies rspecs along application workflow life cycle use standardized guidelines help compute storage resource domain location selection well network path selection based application qspecs sspecs implement security formalization alignment methods framework viz ontimeurb apply exemplar distributed computing workflow show benefits joint qspecs sspecs driven rspecs compliant federated workflow management
dobjectives aim study examine independent impact various care pathways including involving transradial intervention tri day discharge sdd elective percutaneous coronary intervention pci hospital costs background pci associated costs billion annually alternative payment models pci implemented data exist strategies reduce costs various pci care pathways including tri sdd exist association costs outcomes unknown methods total pci patients eligible sdd national cardiovascular data registry cathpc registry linked medicare claims files analyzed hospital costs dollars estimated using cost charge ratios propensity scores tri sdd propensity adjustment via inverse probability weighting performed results pci procedures tri used sdd sdd used cases tri tri transfemoral intervention associated lower adjusted costs confidence interval sdd adjusted cost associated tri sdd cost associated transfemoral intervention non day discharge difference shifting current practice transfemoral intervention non day discharge tri sdd could potentially save hospital performing pcis year million country million annually conclusions among medicare beneficiaries tri sdd independently associated fewer complications lower hospital costs findings important implications changing current pci care pathways improve outcomes reduce costs coll cardiol intv american college cardiology foundation
purpose evaluate degree joint distraction direct arthrography axial traction sports injuries confirm effect axial traction quality wrist opacification patients methods seventeen patients male female underwent wrist arthrography without mean years patients male female axial traction mean years subgroups defined according pathology degenerative ligamentous traumatic normal patients without arthrography lesions radioscaphoid radiolunate lunocapitate ulna triangular fibrocartilage tfc scapho lunate luno triquetral ulnocarpal carpo metacarpal cmc iii distal radio ulnar spaces measured patients differences joint space width compared subgroups joint space opacification subjectively scored opacification fully opacified compared groups without traction results difference joint space statistically significant radioscaphoid radiolunate lunocapitate ulnocarpal spaces patients ligamentous tears opacification score significantly higher ulnocarpal cmc iii joint spaces axial traction conclusion axial traction resulted significantly higher radioscaphoid radio lunate lunocapitate ulnocarpal joint spaces width positive effect axial traction raises suspicion sports ligamentous lesions
study designed determine whether prenatal dexamethasone treatment effect follicular development atresia ovary spiny mouse acomys cahirinus offspring dexamethasone bodyweight per day administered pregnant spiny mice day gestation parturition processes follicle loss analysed using classical markers apoptosis terminal deoxynucleotidyl transferase mediated dutp nick end labelling reaction active caspase autophagy lamp present study indicated dexamethasone reduced pool healthy primordial follicles moreover oocytes follicles showed intensive caspase lamp staining surprisingly dexamethasone caused increase number secondary follicles however follicles characterised extensive degeneration oocyte caspase lamp labelling western blot analysis indicated glucocorticoid receptor well apoptosis autophagy markers strongly expressed dex treated group control basis findings concluded dexamethasone impairs spiny mouse folliculogenesis enhances follicular atresia induction autophagy combined autophagy apoptosis
background recently calreticulin calr gene mutations identified patients essential thrombocythemia high frequency cases without janus kinase jak mutations contain calr mutations exhibit clinical characteristics different mutant jak thus investigated frequency clinical features chinese patients han ethnicity calr mutations methods recruited chinese patients han ethnicity analyze states calr jakvf mplw mutations polymerase chain reaction direct sequencing analyzed relationship mutations clinical features results calr jakvf mplw mutations detected patients respectively mutation types calr involved deletion insertion base pairs type deletion type insertion ttgtc mutations leading delfs insfs respectively three mutations exclusive clinically patients mutated calr lower hemoglobin level lower white blood cell wbc count higher platelet count compared mutated jak furthermore significant difference found wbcs wild type patients triple negative jak mpl calr mutations patients jak mutations patients calr mutations predominantly clustered low intermediate groups according international prognostic score thrombosis conclusions calr mutations frequent chinese patients especially without jak mpl mutations compared jak mutant calr mutant showed different clinical manifestation unfavorable prognosis thus calr potentially valuable diagnostic marker therapeutic target
objective investigate effect diclofenac sodium exposure prenatal development female rat arteries study design pregnant rats separated control saline injected drug treated groups starting day following mating day pregnancy saline daily injected intraperitoneally pregnant rats saline groups respectively injection given rats control group offspring born pregnant rats females chosen end weeks vessel samples removed evaluated using stereological techniques results results indicated significant difference volume fractions tunica media lumen femoral brachial arteries week old female rats moreover significant differences week old female rats terms volume fractions tunica media lumen aortas femoral brachial arteries however significant difference observed condition week old female rats aortas conclusion prenatal exposure female rats may inhibit development arterial system
objectivesto examine caregiver factors associated unmet needs care older adults designpopulation based surveys caregivers older adult care recipients united states setting national health aging trends study national study caregiving participantsfamily caregivers community dwelling older adults disabilities measurementsdisabled care recipient reports unmet needs care past month activities daily living adls wet soiled clothing mobility stay inside instrumental activities daily living iadls medication errors caregiver reported sociodemographic characteristics caregiving intensity tasks performed health psychosocial effects resultsof care recipients reported least one unmet need care past month adl related iadl related younger caregivers caregiving sons caregivers living care recipients supplemental paid caregivers associated unmet needs caregivers recipients reporting two unmet needs likely spend hours per month caregiving help skin care wounds report caregiving emotionally physically difficult report restricted participation valued activities conclusionunmet adl needs prevalent among older adults family caregivers caregivers experiencing high levels burden stress negative physical psychosocial impacts may provide substandard poor care older adults may risk factor neglect clinicians caring disabled older adults assess unmet needs capacity caregivers address
aim obesity associated development metabolic complications insulin resistance mechanisms leading remain unclear study aimed investigate relationship adipose tissue fibrosis obese patients bariatric surgery methods thirty five obese patients awaiting bariatric surgery type diabetes included study non diabetic patients classified either insulin sensitive insulin resistant based matsuda insulin sensitivity index isimatsuda homoeostasis model assessment homa used longitudinal evaluation insulin resistance fibrosis quantified masson trichrome staining microscopy mrna levels fibrosis related genes examined subcutaneous sat visceral adipose tissue vat biopsies collected months bariatric surgery sat results despite similar age body mass index fat mass sat fibrosis significantly higher diabetic insulin sensitive patients associated assessed isimatsuda homa baseline whereas vat fibrosis six months surgery significant weight loss fibrosis levels remained unchanged sat although significantly reduced groups correlation found sat fibrosis surgery conclusion overall results show significant likely transient association sat fibrosis obese humans elsevier masson sas rights reserved
concept social exclusion recently gained attention context online social interactions however little data regarding impact virtual social exclusion subsequent real life social behaviors thus study set examine virtual version common social exclusion scenario cyberball paradigm williams jarvis test behavioral consequences sample students virtual characters agency experience social presence controlled findings indicate ostracized individuals show less prosocial behavior helping task keep seating distance confederate included participants also virtual social exclusion constitutes significant threat fundamental human needs like social control selfesteem belonging causes increase uncertainty sadness anger well decrease happiness avatars agents seemed equally endanger human needs lead seating distance however avatar excluded persons also higher levels sadness less helpful avatar included persons turn confident thus media equation concept nass moon holds true immediate reaction social exclusion avatars agents equally threaten fundamental needs delayed emotional behavioral reactions differ avatars agents possibly preceded cognitive evaluation temporal need threat model williams implications findings everyday online social interactions mmorpg discussed elsevier ltd rights reserved
aim present work investigate influence different types injury risk disability retirement among economically active people denmark material methods prospective study people danish labour force aged years january followed disability retirement age gender standardised incidence ratios sir calculated compare retirement rates among received treatment injury including work related non work related types rates total labour force life table methodology used calculate years lost economically active life yleal injury type results among injured people observed total number cases subsequent disability retirement could statistically attributed injury sir disability retirement injury type ranged least severe types superficial injuries dislocations sprains strains prevalent generated highest numbers yleals conclusion high frequency injuries influence retirement rates suggest injury prevention highly relevant approach reduce future costs disability retirement yleal calculations used set priorities
background data reliability validity assessments irritability particularly behavioral paradigms limited study examined test retest reliability validity frustration paradigm affective posner task two irritability measures affective reactivity index ari child behavior checklist cbcl irritability methods participants youth general population sample twins aged years participants completed two visits weeks apart visits participants completed affective posner task self reported irritability using art parents reported child irritability using ari completed cbcl results affective posner task demonstrated good test retest reliability intraclass correlations iccs ranging task effectively evoked negative affect frustration unhappiness test retest demonstrating construct validity moreover self rated frustration unhappiness frustration components task correlated positively self reported parent reported irritability providing modest support convergent validity parent child reports ari parent reports cbcl irritability measure showed excellent test retest reliability iccs ranging limitations sample consists mostly twins aged years communities thus results may generalize non twin samples clinical samples outside age range conclusions affective posner paradigm ari cbcl irritability scales may useful tools longitudinal treatment research irritability
empathy highly relevant social behavior verbally expressed voicing sympathy concern emotional empathy well paraphrasing stating one mentally reconstruct understand another person thoughts feelings cognitive empathy study investigated emotional effects neural correlates receiving empathic social responses negative performance feedback compared effects emotionally cognitively empathic comments participants male underwent functional magnetic resonance imaging receiving negative performance feedback cognitive task performance feedback followed verbal comments either expressing cognitive emotional empathy demonstrating lack empathy empathic comments general led less negative self reported feelings calmer breathing neural level empathic comments induced activity regions associated social cognition emotion processing specifically right postcentral gyrus left cerebellum cognitively empathic comments right precentral gyrus opercular part left inferior frontal gyrus left middle temporal gyrus emotionally empathic comments well orbital part left middle frontal gyrus left superior parietal gyrus emotionally empathic unempathic comments study shows cognitively emotionally empathic comments appear processed partially separable neural systems furthermore confirming expanding another study subject present results demonstrate social display cognitive empathy exerts almost positive effects recipient feelings emotions states distress emotionally empathic response relevant professional settings strong negative emotions need escalated maintaining professional impartiality may allow display cognitive emotional empathy elsevier inc rights reserved
paper presents theoretical framework intended accommodate circuit devices described characteristics involving two fundamental variables framework motivated recent appearance variety called mem devices circuit theory makes possible model coexistence memory effects different nature single device compact formalism setting accounts classical devices also circuit elements admit two variable description fully nonlinear characteristics allowed devices driving analysis beyond framework chua ventra classify fully nonlinear circuit elements terms variables involved constitutive relations notions differential state order device extend notion topologically degenerate configuration broader context characterize differential algebraic index nodal models circuits additionally explore certain dynamical features ofmem circuits involving manifolds non isolated equilibria related bifurcation phenomena explored family nonlinear oscillators based mem devices
lung transplantation necessary step patients end stage chronic obstructive pulmonary disease use artificial lungs promising alternative natural lung transplantation complicated restricted low organ donations successful lung engineering important choose correct combination specific biological cells synthetic carrier polymer focus study investigate interactions human lung epithelial cell line ncl involved lung tissue development biodegradable poly epsilon caprolactone chemical modification evaluate potential use artificial lung formation also effect polymer chemical modification mechanical surface properties investigated poly epsilon caprolactone surface modified using aminolysis followed immobilization gelatin unmodified modified polymer surfaces characterized roughness tensile strength ncl metabolic cell activity results showed first time possibility nci cells adhere polymeric material resazurin assay showed metabolic activity postseeding presence unmodified greater presence modified polymer observed roughness poly epsilon caprolactone increased film strength increased material chemically modified results obtained date show potential using modified poly epsilon caprolactone scaffold lung tissue engineering
paper proposes novel design variable flux machines alnico magnets proposed design uses tangentially magnetized magnets achieve high air gap flux density avoid demagnetization armature field barriers also inserted rotor limit armature flux allow machine utilize reluctance magnet torque components analytical procedure first applied obtain initial machine design parameters several modifications applied stator rotor designs finite element analysis fea simulations improve machine efficiency torque density prototype proposed design built experimental results good correlation fea simulations confirming validity proposed machine design concept
paper mainly focuses conceptual design stealth performance three surface military aircraft three dimensional digital mock three surface strike fighter stealth feature designed schemes carrying missiles analyzed catia based physical optics principle method equivalent currents mec numerical simulation rcs feature aircraft carried rcsplus software designed beihang university paper contributes rcs feature analysis whole plane different parts band hand band comparison rcs feature military aircraft drawn band pitch angle incident wave degrees result shows compared aircraft forward scattering rcs three surface strike aircraft reduced side scattering rcs back scattering rcs compared aircraft forward scattering rcs reduced side scattering rcs paper useful researchers conceptual design stealth technology military aircraft
potentiodynamic polarization electrochemical impedance spectroscopy weight loss methods used study inhibition corrosion steels saturated naci solution various concentrations imidazoline based inhibitor inhibition efficiencies reached respectively sufficient concentration inhibitor results indicated inhibition efficiencies dramatically different low concentration inhibitor compared exhibited higher inhibition efficiency stronger adsorption ability larger amount homogeneous distribution carbides adsorption inhibitor metal surface consisted mix physisorption chemisorption observed follow langmuir adsorption isotherm elsevier rights reserved
software product line spl configuration management multi dimensional problem one hand core assets constitute configuration need managed hand product product line built using configuration must managed furthermore management configurations must coordinated single process therefore product lines complex single systems software system involves four closely related activities change management chm version management system building release management sommerville software engineering edn addison wesley aim paper provide chm models evolutionary based spl system development maintenance proposed models support level aggregation spls applied mobile spl case study
background subscapularis insufficiency debilitating condition treatment options historically pectoralis major tendon transfer suggested subscapularis tendon muscle deemed irreparable however results salvage procedure mixed methods comprehensive review peer reviewed literature addressing pectoralis major tendon transfers performed clinical presentation relevant anatomy biomechanical rationale surgical indications technical considerations reported outcomes significant complications reviewed report possible attempts direct comparison outcomes among surgical techniques surgical indications made results conclusions despite heterogeneous reporting clinical results clear surgical indications affect outcomes specifically isolated subscapularis insufficiency shows best prognosis pectoralis major tendon transfer patients anterosuperior instability large rotator cuff tears shoulder arthroplasty least predictable pain relief worse functional outcomes level evidence review article journal shoulder elbow surgery board trustees
contribution propose analysis absorbing capabilities planar structures loaded left handed material lhm based resonant magnetic inclusions operating microwave frequencies end present general formulation valid characteristic property lhm demonstrated medium proposed constitutive properties achieved common limitations present day absorbers like presence metallic plates overcome shown also introduction lhm leads enlargement angular bandwidth reduction overall dimensions component numerical results together remarks possible practical implementations proposed components also given
analysis filtered least mean square fxlms algorithm based either stochastic deterministic approach one drawbacks stochastic analysis relies several assumptions justified reference signal time periodic overcome limitations several deterministic methods suggested however useful results reported setups certain filter length secondary path model reference signal paper exact linear time periodic ltp representation proposed assuming reference synchronously sampled representation derived general fxlms system also covers multichannel topology several parallel filters common narrowband modification representation found linear time invariant lti form filter length suitably chosen usability method demonstrated numerically computed example comparing approximate lti model
introduction nitric oxide modulates inflammatory reactions beneficial toxic effects depending concentration elevation cause proinflammatory effects amplifying inflammatory process participation cytokines smoking negative impact health considered one risk factors influence disease development facilitating inflammatory processes aim compare serum concentration cytokines smokers baseline months abstinence treatment methods blood samples collected obtain serum baseline months stored degrees analysis measured total dose nitrite determined greiss method cba used technique determine concentration cytokines supernatants serum initial final results tnf alpha remained months treatment compared wilcoxon test used compare data spearman test correlations variables significance level adopted results analysis observed significant reduction initial median value mol mol months treatment significant differences cytokines baseline end treatment conclusion results may mean harm body adaptive process decreasing metabolism abstinents due reduction use nicotine elsevier ireland ltd rights reserved
research paper reports utilization hydrogel gelatine hybrid nanocomposite clinoptilolite adsorption ions aqueous solution multi metal ions mine effluents hydrogel synthesized using graft polymerization acrylamide aam onto hybrid hydrogel nanocomposite prepared incorporating clinoptilolite within hydrogel matrix synthesized polymers characterized using different characterization techniques ftir xrd sem tga adsorption behaviour synthesized adsorbents adsorption studied using different adsorption parameters temperature adsorbent dosage adsorption kinetics followed pseudo second order rate equation whereas adsorption isotherm followed freundlich langmuir isotherm models thermodynamics studies revealed adsorption processes spontaneous endothermic nature moreover synthesized adsorbents also successfully utilized adsorption different metal ions mine effluents korean society industrial engineering chemistry published elsevier rights reserved
study objective assess ability new iteration essure insert ess achieve short term fallopian tube occlusion design prospective single center interventional cohort canadian task force classification setting tertiary care hospital patients women scheduled undergo hysterectomy intervention patients underwent placement ess right fallopian tube ess commercially approved previous version device left fallopian tube days planned hysterectomy tubal occlusion assessed via hysterosalpingography hsg time placement hysterectomy ultrasound used evaluate acute device placement measurements main results thirty five women mean age years enrolled july january underwent essure placement scheduled hysterectomy mean placement time ess ess devices minutes minutes respectively hour ess placement tubes exhibited complete occlusion hsg compared tubes ess placement difference occlusion rates hysterectomy tubal occlusion rate high groups ess ess tubes high occlusion rates observed duration groups days five women experienced minor adverse effects conclusion ess modification commercially available ess designed cause immediate tubal occlusion demonstrated high rate immediate term intermediate term tubal occlusion early tubal occlusion may obviate need interim alternative contraceptive methods essure placement aagl rights reserved
paper presents pid controller link voltage single phase switched boost inverter sbi unlike link voltage controller source inverter zsi presented controller directly controlled via capacitor voltage using controller constant capacitor voltage achieved input voltage load changed suddenly prototype built verify proposed controller simulation experimental results shown
social network analysis presupposes observed social behavior influenced unobserved network traditional approaches inferring latent network use pairwise descriptive statistics rely variety measures occurrence techniques proven useful wide range applications literature describe generating mechanism observed data network previous article authors presented technique used finite mixture model connection unobserved network observed social behavior model assumed group result star graph subset population thus group result leader selected members population group called hub models approach treats network values parameters model however leads general challenge estimating parameters must addressed small datasets far parameters estimate observations conditions estimated network unstable article propose solution penalizes number nodes exert leadership role implement pseudo expectation maximization algorithm demonstrate technique series simulations show number leaders sparse parameter estimation improved apply technique dataset animal behavior example recommender systems elsevier rights reserved
radio interfaces satellite component imt advanced system recently developed international telecommunication union radiocommunication itu specified recommendation itu set techniques specified recommendation used provide high quality mobile satellite services efficient spectrum utilization candidate services include multimedia broadband services handheld portable terminals public protection disaster relief services paper presents brief background standardization procedure describes technical characteristics satellite radio interfaces specified itu recommendation
rapid developments network technology devices connected network variety fields increased network security become important rule based classification intrusion detection useful easily understood humans also accurate classification new patterns genetic network programming gnp one rule mining techniques well evolutionary optimization techniques extract rules efficiently even enormous database still needs accuracy stability practical use paper describes classification system random forests employing weighted majority vote classification enhance performance performance evaluation nsl kdd network security laboratory knowledge discovery data mining data set used proposed method compared conventional methods including machine learning techniques random forests svm terms accuracy false positive rate
decades independent morphological functional brain research key point neuroscience nowadays understand combined relationships structure brain components dynamics multiple scales ranging circuits neurons micro mesoscale brain regions macroscale goal mind vast amount research focusing modeling simulating activity within neuronal structures simulations generate large complex datasets analyzed order gain desired insight context paper presents visimpl integrates set visualization interaction tools provide semantic view brain data aim improving analysis procedures visimpl provides particle based rendering allows visualizing simulation data associated spatial temporal information enhancing knowledge extraction process also provides abstract representations time varying magnitudes supporting different data aggregation disaggregation operations giving also focus context clues addition visimpl tools provide synchronized playback control simulation analyzed finally visimpl allows performing selection filtering operations relying application called neuroscheme views loosely coupled used independently also work together linked views centralized distributed computing environments enhancing data exploration analysis procedures
extracellular vesicles evs including exosomes play key role inter intracellular communication promoting proliferation invasion recipient cells support tumor growth metastasis metastasis comprises multiple steps first include detachment tumor cells epithelial mesenchymal transition emt allowing physical dissemination distant organs thereafter cancer derived exosomes still critical components preparing tumor microenvironment enabling tumor cells escape immunological surveillance arranging pre metastatic site engraftment detached cancer cells review discuss multifaceted role evs multiple steps metastasis future research directions draw attention evs biological targets cancer diagnosis prognosis therapy however due significant role cell communication may become valuable drug delivery system
main purpose research aims design vacuum removal brain tumors disconnectors microdestruccion integrated control system development project remove tumor brain thus improve standard living patient design developed different types cutting tools thus obtaining disconnector hard tissue soft tissue hand designed using vacuum techniques fluid mechanics suction cannulae consist small metal nozzle direct contact patient system open loop control monitor control system variables suction pumping irrigation fluid level control tanks tumor material order obtain computer user friendly designed subsequently verified simulator automation studio operation control system finally analysis technical economic feasibility obtaining final solution feasible implementation country conducted
pisotriquetral semilateral view wrist may improve assessment pisotriquetral osteoarthritis reliability reproducibility unclear purpose cross sectional observer study investigate inter intraobserver agreement evaluating pisotriquetral using pisotriquetral views special focus sclerosis joint space width jsw narrowing osteophyte formation incidence latter radiographic features patients suspected pisotriquetral five independent observers rated independently two different occasions pisotriquetral views patients treated ulnar sided wrist pain suspected pisotriquetral requiring pisiform resection agreement calculated using kappa statistic agreement observers ranged fair moderate average intraobserver agreement ranged moderate moderate ratings jsw narrowing observed followed osteophyte formation sclerosis observers found especially difficult detect jsw narrowing despite availability pisotriquetral view enhance visualization pisotriquetral joint assessment specific features indicating pisotriquetral leads fair moderate agreement limits applicability radiographic assessment rationale reliable radiologic approach assessing level pisotriquetral needed may require use advanced imaging techniques
sustained destructive leadership behaviours associated negative outcomes produce serious workplace problems yet scant research followers effectively cope toxic leader behaviours despite numerous attempts develop typologies coping behaviours remains much learn especially relation specific workplace stressor mixed method research investigates coping strategies reported followers cope psychological emotional physical consequences leader adverse behaviour coping instances categorized using two existing theoretical coping frameworks ability frameworks explain responses real world experiences toxic leadership discussed common coping strategies reported included assertively challenging leader seeking social support ruminating taking leave leaving organization organizational interventions increase effectiveness follower coping impact toxic leadership also discussed copyright john wiley sons ltd
research parental social support chiefly examined received social support studies suggested provided social support may also protective child mental health problems aim investigate association parental social interaction received provided social support offspring behavior problems analyzed data households including children aged years japanese study stratification health income neighborhood shine survey conducted used point likert scale assess social interaction including parental emotional instrumental support received provided spouse residing family members non residing family members relatives neighbors friends behavior problems offspring assessed using parental responses strengths difficulties questionnaire associations parental social interaction behavior problems analyzed using ordered logistic regression found higher maternal social interaction significantly associated lower odds difficult prosocial behavior problems associations found paternal social interaction maternal provided social support showed independent negative association prosocial behavior problems offspring even adjusted received maternal social support paternal social interaction study showed maternal social interaction paternal social interaction might protective effect offspring behavior problems study required investigate effect intervention increase social participation among mothers whose children behavior problems
objectives study examine effects horticultural activity program emotional intelligence prosocial behavior scientific investigation abilities attitudes kindergarteners total children aged years public private kindergartens day care centers incheon south korea participated session horticultural activity program program included indoor outdoor activities planting seeds transplanting plants making applying eco friendly fertilizer watering harvesting using plants make crafts cooking produce designed improve emotional intelligence prosocial behavior scientific investigation abilities attitudes kindergarteners session lasted average minutes held per week results study showed session horticultural activity program improved emotional intelligence prosocial behavior scientific investigation abilities attitudes children satisfaction program high among children teachers parents future studies consider exploring effects horticultural activity programs children different age groups
paper presents experimental characterization arc fault phenomenon systems focusing attention series arcs aim study find current characteristics significant purpose arc detection arcing current signal analyzed time frequency domain analysis test conditions chosen accordance unwanted tripping tests operation inhibition tests reported standard study carried currents waveforms acquired field tests plant starting study herein presented authors found possible suitably detect arc faults systems using high resolution low frequency harmonic current analysis
wake recent advances experimental methods neuroscience ability record vivo neuronal activity awake animals become feasible availability rich detailed physiological measurements calls development advanced data analysis tools commonly used techniques suffice capture spatio temporal network complexity paper propose new hierarchical coupled geometry analysis implicitly takes account connectivity structures neurons dynamic patterns multiple time scales approach gives rise joint organization neurons dynamic patterns data driven hierarchical data structures structures provide local global data representations local partitioning data flexible trees new multiscale metric global manifold embedding application techniques vivo neuronal recordings demonstrate capability extracting neuronal activity patterns identifying temporal trends associated particular behavioral events manipulations introduced experiments
medium large construction projects typically involve multiple structural consultants use wide range structural analysis applications applications technologies inadequate interoperability still dearth investigations addressing interoperability issues structural engineering domain paper proposes novel approach combines industry foundation classes ifc based unified information model number algorithms enhance interoperability architectural structural models among multiple structural analysis models bidirectional conversion round tripping proposed approach aims achieve conversion overcoming inconsistencies data structures representation logics syntax used different software applications approach implemented client server browser server environments enable central remote collaboration among geographically dispersed users platforms tested four large real life projects testing involved four key scenarios bidirectional conversion among four structural analysis tools comparison conversion via proposed approach conversion via direct links among involved tools direct export ifc based architectural tool application program interface api conversion visualization structural analysis results scenarios successfully performed tested four significant case studies particular conversion among four structural analysis applications etabs sap ansys midas successfully tested possible conversion routes among four applications two case studies project project first four steps natural mode shapes natural vibration periods calculated compared converted models achieved within standard deviation sin project project respectively indicating accurate conversion elsevier rights reserved
note one concerns problem robust adaptive path following control uncertain underactuated ships fields marine practice waypoints based navigation novel logical virtual ship lvs based steering law developed programme rational reference route guidance underactuated ship practical engineering furthermore practical adaptive neural control algorithm proposed virtue dynamic surface control dsc technique neural networks approximation polar coordinates scheme much effort made obtain semi global uniform ultimate bounded stability closed loop control system using lyapunov synthesis advantages developed control scheme first could tackle practical condition waypoints based navigation meaningful applying existed theoretical algorithm control engineering second developed neural controller able capture vehicle uncertainties without exact information hydrodynamic damping structure sea disturbances characteristics would facilitate implementation algorithm marine practice two numerical examples given illustrate performance effectiveness proposed scheme elsevier ltd rights reserved
wideband probe type microstrip waveguide transition integrated low temperature fired ceramic ltcc presented experimentally verified enhance bandwidth air hole matching structure besides probe buried ltcc substrate implemented drilling square holes different substrate layers microstrip waveguide transition fabricated verify design compact size measured results show good agreement simulated results
background hairdressers risk developing occupational contact dermatitis intense contact wet work combination chemicals objectives perform analysis cohort study hairdressers occupational contact dermatitis recognized period focusing individual environmental factors associated disease methods study descriptive register based survey including hairdressers recognized occupational contact dermatitis denmark period january september data obtained danish national board industrial injuries results study comprised patients women men median age years apprentices fully trained hairdressers prevalence atopic dermatitis significantly higher among apprentices among fully trained hairdressers respectively patients dermatitis recognized occupational irritant contact dermatitis dermatitis recognized occupational allergic contact dermatitis combined allergic irritant contact dermatitis recognized occupational contact urticaria conclusion low median age high percentages atopic dermatitis apprentices fact apprentices fully trained hairdressers recognized occupational contact dermatitis underlines importance early prevention
culture origin decisively influences speakers cognitive world also communicative patterns come play face face interactions one patterns tendency solve situations direct indirect interactions also depends degree familiarity interlocutors goal activities suggested avoid misunderstandings may arise circumstances encourage communicative success designed develop four elements take part interaction intercultural strategies student possesses variability communicative pattern depending cultures origin formal linguistic resources nonverbal communication
paper low power precise electrical stimulator introduced operational amplifier opamp used electrical stimulations low pulse width opamp high slew rate needed power consuming work opamp substituted digital circuitry khz clock also used update current stimulator stimulation phases order make stimulator accurate enough producing clock needs micro watts stimulator simulated cmos process well simulation results shows stimulator charge mismatch stimulation current pulse width
background previous studies suggest adults tourette syndrome respond unconventionally tasks involving social cognition therefore hypothesized patients would exhibit different neural responses healthy controls response emotionally salient expressions human eyes method twenty five adults matched healthy controls scanned using fmri standard version reading mind eyes task requires mental state judgements novel comparison version requiring judgements age results prompted mental state recognition greater activity apparent within left orbitofrontal cortex posterior cingulate right amygdala right temporo parietal junction tpj reduced activity apparent regions including left inferior parietal cortex age judgement elicited greater activity within precuneus medial prefrontal temporal regions involved mentalizing interaction group task revealed differential activity areas including right inferior frontal gyrus task related activity tpj covaried global ratings urge tic conclusions recognizing mental states adults exhibit greater activity controls brain areas involved processing negative emotion addition reduced activity regions associated attribution agency addition increased recruitment areas involved mental state reasoning apparent patients mentalizing task requirement findings highlight differential neural reactivity response emotive social cues may interact tic expression
software support simulation electrical circuits developed sixty years currently standard tools simulation analogous circuits simulators based open source package simulation program integrated circuit emphasis generally known spice biolek many different applications provide graphical interface extended functionalities basis spice least using spice models electronic devices author paper performed simulation circuit acts electronic diode multisim provides comparison simulation results results obtained measurements real circuit
background malvidin alvidin glucoside polyphenol belongs class natural anthocyanin abundantly found red wines colored fruits skin red grapes therefore current investigation intended evaluate effect malvidin myocardial infarction induced isoproterenol rats material methods cardioprotective effects assessed determining effect malvidin activities endogenous antioxidants catalase cat superoxide dismutase sod glutathione peroxidase gsh levels lipid peroxidation serum marker enzymes serum levels tnf alpha also determined using enzyme linked immunosorbent assay elisa kit result present study demonstrated significant cardioprotective effect malvidin restoring defensive activities endogenous antioxidants catalase cat superoxide dismutase sod glutathione peroxidase gsh reducing levels lipid peroxidation serum marker enzymes lactate dehydrogenase creatine kinase malvidin significantly ameliorated histopathological changes impaired mitochondria cardiac necrosis stimulated isoproterenol additionally results also demonstrated nuclear translocation nrf subsequent expression might associated nuclear factor kappa kappa pathway activation conclusions findings suggest malvidin exerts cardioprotective effects might due possible strong antioxidant anti inflammatory activities therefore study provides basis development malvidin safe effective treatment myocardial infarction
seeking proximity another person immediately expresses affiliafive intentions highly relevant experiencing social exclusion novel task current study investigated relation proximity observed ostracism early childhood sample children age months first watched priming videos either depicting ostracism subsequently children saw four seats varying distances interactant seat chose sit children observed social exclusion selected seats higher proximity results suggest young preschoolers immediately express threatened need belong literally getting closer even stranger witnessing ostracism task provides new opportunities test reactions social exclusion early childhood elsevier inc rights reserved
culverts built locations waterway crosses road railway creates limitation flow passage furthermore blockage commonly occurs flood events accumulation debris culvert inlet inlet blockage changes flow structure outlet may result culvert failure despite impacts blockage culvert hydraulics downstream waterways received consideration literature purpose paper mitigate deficiency reporting investigation scouring outlet partially blocked culverts experimental tests conducted steady flow investigate relationship maximum scour depth blockage ratio culvert flow characteristics non blocked partially blocked conditions considered consideration results obtained showed scoured area maximum scour depth increased partially blocked culverts conditions compared equivalent non blocked culverts
objective absence markers ante mortem diagnosis idiopathic parkinson disease ipd multiple system atrophy msa progressive supranuclear palsy psp results disorders commonly mistaken particularly initial stages aimed investigate annualized whole brain atrophy rates wbar disorders aid diagnosis ipd psp msa methods ten healthy controls ipd psp msa patients studied using structural imaging evaluation normalization atrophy siena siena mri based algorithm quantifies brain tissue volume require radiotracers siena shown low estimation error atrophy rate whole brain results controls wbar ipd wbar ipd patients differ controls psp wbar msa wbar msa differ psp wbar psp msa significantly higher ipd wbar differentiated patients ipd psa msa sensitivity specificity conclusions wbar within normal range unlikely observed psp msa wbar may add potential retrospective application improve diagnostic accuracy msa psp ipd first year clinical assessment
plasma stealth technology many unique advantages hence promising application aviation aerospace fields attenuation characteristics vertical incidence electromagnetic waves unmagnetized plasmas metal underlay studied theoretically experimentally paper regulations change electromagnetic wave attenuation plasma parameters analyzed theory using wkb method large area plasma slab generated stably inductively coupled discharge reflectivity arch test system plasma slab set attenuation effects electromagnetic wave unmagnetized plasmas studied experimentally electron density plasma generated different discharge powers obtained using microwave phase plasma spectrum diagnostic technique ranging plasma generated inductively coupled plasma icp effect attenuation electromagnetic waves experimental results accord well theoretical ones results show increasing plasma electron density covering homogeneity contribute improving attenuation effect plasma electromagnetic waves
many problems computer aided geometric design computer graphics turned root finding problem polynomial equations among various clipping methods ones based bernstein bezier form good numerical stability one clipping methods clipping method often called cubic clipping method utilizes time find two polynomials degree bounding given polynomial degree achieves convergence rate single root roots bounding polynomials degree used bounding roots paper presents rational cubic clipping method finding two bounding cubics within time achieve higher convergence rate previous cubic clipping method bounding cubics obtained remaining operations previous cubic clipping method numerical examples show efficiency convergence rate new method elsevier inc rights reserved
water pollution become global problem impact health human population growing day day study aims assess pollution cibin river romania physicochemical analysis water samples collected four locations along cibin river period months time several commonly used multiple criteria decision analysis mcda methods assessing impact pollutants environment research used analytic hierarchy process ahp multi criteria method evaluate sampling station physicochemical parameters significant results place river first sampling stations second sampling stations water quality classes another significant result work research using gis software allowed integrated automatic data collection system displays interactive results
controllable sensitive perception environmental changes essential development smart material device systems herein multi stimuli sensitive responsor fabricated base established double helix core sheath graphene based microfibers gfs combining tunable conductivity mechanical robustness coated graphitic carbon nitride gcn fibriform smart environmental responsor ser prepared water assisted gfs twisting strategy accordingly present conductive state dependent current responses upon exposure variety stimuli importantly ser exhibits high current response small perturbations induced temperature variations mechanical interactions relative humidity changes thereby achieving environmental perceptibility based finding multi functional respiratory monitor built stimuli human breath
system presented emulate mouse movement head eyelids position head used controlling horizontal vertical displacement cursor closing eyelids activate click right left buttons system includes zoom navigation shortcuts vertical scrollbars menus activation according cursor position enhance functionality facilitate handling applications proposed solution eliminates restriction direct contact mouse empowers people motor disabilities upper extremities interact computer mouse emulator also used people without limitations expand command instructions system tested navigation social network facebook average speed pixels obtained average accuracy pixels axis pixels axis however user interaction interface improvements observed execution time location accuracy respectively click activation temporary location menu option performance right left clicks eyelid closing performance respectively finally surveys showed high satisfaction proposed interface user interaction facebook
background limited number studies investigated safety efficacy repetitive transcranial magnetic stimulation rtms treatment resistant depression outpatient private practice setting hypothesized rtms would safe effective treatment resistant depression nonresearch population methods treated outpatients unipolar bipolar depression experiencing moderate severe treatment resistant major depressive episode mde treatment based flexible dose schedule either rtms applied left dorsolateral prefrontal cortex modified parameters assessments performed baseline weekly basis patients received least trials antidepressant medication adequate dose duration without satisfactory improvement index mde results significant change montgomery asberg depression rating scale scores baseline end week responders achieved remission major side effects observed aside mild headache patients conclusions rtms applied left dorsolateral prefrontal cortex safe effective important subset outpatients moderate severe mde naturalistic setting outcomes demonstrated response rates similar research populations larger studies needed confirm safety effectiveness rtms naturalistic conditions
great number heterogeneous interconnected operating systems gives greater access intruders makes easier malicious users break systems security policy also single security control agent insufficient monitor multiple interconnected hosts protect distributed operating systems hostile uses paper shows ability distributed security controller agents correlate data stream heterogeneous hosts trace abnormal behavior order protect network security experimental study done improve proposed approach
known logic bunched implications logic resources many studies reported applications computer science paper extension bis adding sequence modal operator introduced studied order formalize fine grained resource sensitive reasoning sequence modal operator bis appropriately express sequential information resource sensitive reasoning gentzen type sequent calculus sbis bis introduced cut elimination decidability theorems sbis proved extension grothendieck topological semantics introduced bis completeness theorem respect semantics proved cut elimination decidability completeness theorems sbis bis proved using theorems embedding bis elsevier rights reserved
parallel efficient global optimization ego algorithms focus parallel architectures producing multiple updating points give attention balance global search sampling different areas search space local search sampling intensely one promising area search space updating points study novel approach proposed apply idea accelerate search parallel ego algorithms cycle proposed algorithm local maxima expected improvement function identified multi modal optimization algorithm local maxima value greater threshold selected candidates sampled around selected maxima results numerical experiments show although proposed parallel ego algorithm needs evaluations find optimum compared standard ego algorithm able reduce optimization cycles moreover proposed parallel ego algorithm gains better results terms number cycles evaluations compared state art parallel ego algorithm six test problems
recently emerging view music cognition holds music social participatory production also perception music fact perceived sonic trace social relations group real virtual agents view appears compatible number intriguing music cognitive phenomena links beat entrainment prosocial behaviour strong musical emotions empathy direct evidence lacking listeners able use acoustic features musical interaction infer affiliatory controlling nature underlying social intention created novel experimental situation asked expert music improvisers communicate types non musical social intentions domineering disdainful conciliatory one another solely using musical interaction using combination decoding studies computational psychoacoustical analyses show musically trained non musically trained listeners recognize relational intentions encoded music social cognitive ability relies sizeable extent information processing acoustic cues temporal harmonic coordination present one musicians channels emerge dynamics interaction manipulating cues two channel audio recordings testing impact social judgements non musician observers finally establish causal relationship affiliation dimension social behaviour musical harmonic coordination one hand control dimension musical temporal coordination hand results provide novel mechanistic insights social cognition musical interactions also non verbal interactions whole authors published elsevier
present method identify dynamics human arm controlled implanted functional electrical stimulation neuroprosthesis method uses gaussian process regression predict shoulder elbow torques given shoulder elbow joint positions velocities electrical stimulation inputs muscles compare accuracy torque predictions nonparametric semiparametric parametric model types accurate three model types semiparametric gaussian process model combines flexibility black box function approximator generalization power parameterized model semiparametric model predicted torques stimulation multiple muscles errors less total muscle torque passive torque needed drive arm identified model allows define arbitrary reaching trajectory approximately determine muscle stimulations required drive arm along trajectory
parkinson disease associated procedural learning deficits nonetheless studies demonstrated reward related learning comparable patients controls bdi brain frank seeberger reilly science palminteri proceedings national academy sciences united states america however studies separate effect reward effect practice difficult determine whether effect reward learning distinct effect corrective feedback learning thus unknown whether group differences learning due reward processing learning general compared performance medicated patients demographically matched healthy controls hcs task effect reward examined separately effect practice found patients showed significantly less reward related learning improvements compared hcs addition stronger learning rewarded associations unrewarded associations significantly correlated smaller skin conductance responses hcs patients results demonstrate separating effect reward effect corrective feedback patients benefit reward
applying signal flow graph sfg based filter synthesis active ota topology integration degree elliptic lowpass filter designed dynamic range maximized single ended ota filter floating capacitors done use optimizing circuit simulator thus low voltage operation despite high signal amplitudes achieved linearized operational transconductance amplifier ota designed optimized filter comparison purposes single ended design converted fully differential one additional gain integrated filters realized cmos process thoroughly measured filters especially applicable mobile communications low power consumption
background cerebral palsy common pediatric disability causing long term functional limitations remarkably influences life affected families reason important necessary direct attention type also impact disorder child parents siblings entire family whole aim study assess impact child quality life considering parents perceptions child illness order underline impact illness child also family methods study included parents subjects enrolled males females established diagnosis effect families assessed using impact childhood illness scale questionnaire assesses quality life children epilepsy chronic pathologies families questions refer effect illness family scale comprises questions divided four sections impact illness treatment impact development child adjustment impact parents impact family descriptive analyses used data analysis also calculated rank correlation coefficient spearman rho results conclusion mothers group presents little higher average scores group fathers two four subscales basement impact child family impact organization could due fact mothers concerned child caregiver living difficulties entails mothers show greater concerns fathers subscale impact parents average score answers group mothers coincide fathers experience experience son illness analogous parents significant differences found correlational analysis individual items subscales different forms families children strategies optimizing caregiver physical psychological health include supports behavioral management daily functional activities well stress management self efficacy techniques
canonical poisson bracket algebra four dimensional relativistic mechanics used derive equation motion charged particle lorentz force homogeneous maxwell equations
hegemonic masculinities sets socially accepted masculine behaviors beliefs within given time culture may affect well sexual minority men yet quantitative relationships masculinities well remain largely unexplored using data national cross sectional survey young sexual minority men ages years current study examined relationship parental gender policing childhood adolescence subsequent substance use psychological distress one third sample reported parent person raised policed gender including use disciplinary actions using multivariable regression study examined relationship parental gender policing psychological well substance use adjusting age race ethnicity educational attainment current student status gender policing childhood adolescence associated recent substance use behaviors psychological distress multivariable models linear association substance use behaviors psychological distress number disciplinary actions experienced childhood adolescence also observed parents attempts police sons gender expression associated markers distress among young sexual minority men relationship parental gender policing childhood adolescence distress among young sexual minority men discussed
article presents introductory microcontroller programming course digital signal processing undergraduate university level course intended provide insight information technology prepare students complex exercises later studies solutions overcome pedagogical obstacles like fear new technologies minimise technological incompatibilities different operating systems setting programming tool chain presented leads increased scalability course allowing hundreds students attend year case presented average number participants problem oriented task assignments defined leading final creative improvement task students solutions analysed course evaluated outlook improvements given
background childhood adversities emotional dysregulation connected chronic pain alexithymia depression longitudinal studies exploring impact occurrence pain situation rare aims influence alexithymia depression baseline pain situation treatment options course chronic pain clinical sample studied methods baseline data collected chronic pain patients first pain clinic visit follow data year self report questionnaires study variables consisted pain intensity pain disability alexithymia tas depression bdi treatment interventions statistical analyses performed find differences baseline follow well alexithymic non alexithymic patients estimate effect treatment provided results follow majority patients pain intensity disability severe enough disrupt daily living none treatment interventions related better outcome alexithymic patients reported pain disability depression baseline follow effect alexithymia pain disability mediated depression use opioids connected alexithymia depressiveness alexithymia depression made substantial contribution poorer outcome conclusions severe pain intensity disability depression alexithymia predicted difficulties achieving improvement depression alexithymia probably impair compliance treatment adherence interventions occurrence severe pain situation use opioids indicates psychological problems underlying pain experience
converting infrared radiation form heat electricity one interesting energy conversion approaches simply accomplished thermoelectric effect well known device called thermoelectric cooler tec paper briefly overview tec based concepts demonstrations products converting heat electricity propose portable tec based heat electricity converting module experimental proof concept also highlighted showing promising output voltage vdc suitable low voltage applications future work relates design optimization engineering improvement testing real world scenario
water resources management may face serious challenges climate change order efficiently utilize water resources reduce loadings centralized water supply systems necessary water user reduce water requirements rural community consumes great portion water resources taiwan due high irrigation water demands thus concerned study rural community considers external domestic water supply irrigation systems installing reuse system constructed wetland provide harvested rainwater reclaimed water purpose study establish integrated water resources system dynamics model propose indicators quantitatively evaluating water supply system rural community three indicators designed evaluate water saving efficiency tolerance drought duration influence insufficient irrigation water crop yields results show combination constructed wetland reuse system possesses eminent stability reuse system alone integrated water resources system may reduce domestic water demands irrigation water demands external systems respectively time domestic system owns higher resilience conclusion results indicate reuse system constructed wetland significantly improve stability resilience water supply system study integrated water resources system rural community desires researches besides influence climate change water quality reclaimed water considered
background objectives body mass index bmi shown important predictor bone mineral density bmd objective study investigate relationship anthropometric measures including body mass index bone mineral density postmenopausal non osteoporotic osteopenic osteoporotic women methods cross sectional study postmenopausal females years age recruited divided three groups non osteoporotic osteopenic osteoporotic females anthropometric measures bone mineral density assessed anova applied compare groups post hoc tuckey test used formultiple comparisons groups spearman rho correlation used establish correlations results body mass index hip circumference significantly higher osteopenic compared osteoporotic females waist hip ratio significantly higher osteoporotic compared non osteoporotic females significant positive correlation body mass index found score ultrasound bone profile index postmenopausal females conclusion high body mass index associated high bone mineral density reduced fracture risk postmenopausal females increasing age high waist hip ratio also lead reduced bone mineral density postmenopausal females
success electric vehicles evs greatly depends battery size cost lifetime capacity battery capacity evs contain enough energy allow users drive least minimum distance internal combustion engine vehicles take however even efficient evs combining available highly efficient technologies battery capacity still needs large thus one alternative reduce battery size improve charging infrastructure implementing sufficient public private fast charging locations significantly increase driving range relatively low battery capacities however kind infrastructure requires charging higher current capability due high power levels involved fast charging process paper bidirectional converter six inverter legs connected three phase output proposed converter similar three phase dual active bridge dab converter inverter legs parallel additional inverter legs increase converter current capability without affecting dab main characteristics preserving similar modulation techniques dab advantages accurate study proposed topology carried paper simulations experimental results shown prototype validating theoretical analysis
subtropical forest ecosystems play essential roles global carbon cycle carbon sequestration functions challenge traditional understanding main functional areas carbon sequestration temperate forests europe america leaf area index lai important biological parameter spatiotemporal simulation carbon cycle considerable significance carbon cycle research dynamic retrieval based remote sensing data important method obtain large scale high accuracy assessments lai study developed algorithm assimilating lai dynamics based integrated ensemble kalman filter using modis lai data modis reflectance data canopy reflectance data modeled prosail three typical types subtropical forest moso bamboo forest lei bamboo forest evergreen deciduous broadleaf forest china errors assimilation winter bad data quality modis product overall assimilated lai well matched observed lai rmse abias moso bamboo forest lei bamboo forest evergreen deciduous broadleaf forest respectively algorithm greatly decreased uncertainty modis lai growing season improved accuracy modis lai advantage algorithm use biophysical parameters measured lai lai assimilation makes possible assimilate long term modis lai time series data provide high accuracy lai data study carbon cycle characteristics subtropical forest ecosystems international society photogrammetry remote sensing inc isprs published elsevier rights reserved
objectivecould website developed would evidence based lead readers positive cognitions locus control self efficacy respect managing headaches current websites methoda new website developed based learning cope headache triggers rather traditional advice avoid triggers existing commonly accessed influential website used comparative purposes equal length equivalent readability new website sixty two participants female male suffered frequent headaches least months randomly assigned reading one website followed completing following measures headache management self efficacy scale headache specific locus control scale survey including questions confidence optimism respect managing headaches resultsanalyses indicated readers coping website compared traditional website higher self efficacy lower chance locus control difference groups internal locus control significant family wise error adjustments made readers coping website felt confident managing headaches optimistic managing headaches optimistic headaches might decrease frequency intensity duration conclusionwebsites need periodic revision research literature unfolds website designers take account cognitive impact websites
usage inercial sensors widespread many areas especially aueronautics another field use sensors capturing recognizing gestures sensors placed human body parts example hand shoulder article dealing proposal weareable sensors capable detecting simple gestures rotation elevation movement etc system based stm platform guarantee low energy consumption sufficient performance evaluate captured motions multilayer neural network capable recognizing elementary gestures designed detect movements hand rotations hand vertical horizontal movements
viewpoints brazilian opinion leaders regarding cancer yet well defined examining public perceptions three segments society qualitative study may provide clues understanding negative view population still disease journalists scientists teachers participated discussions six focus group sessions findings studied using content analysis method showing similar elements among professionals regardless area operation identified negative view may contributing mirroring vision society associates illness death suffering although opinion leaders believe able filter certain negative aspects media dissemination cancer disease affects personally feeling despair resembles common sense words cure viewed prejudice hand morbid approach arouses interest subject also noted disclosure celebrity cancer stands decoy consumption news distortions may support actions enhance communication cancer structured pillars prevention early diagnosis cure
aim provide overview traumatic injuries sustained players america cup material methods collected medical reports matches held america cup chile twelve american teams took part championship consisted matches total players physician team sent request form traumatic injuries sustained including time injury produced location diagnosis severity circumstances contact injury sanction treatment required results mean number minutes played minutes injury occurred every minutes means injuries per minutes match time found injuries players non contact injuries contact injuries declared fouls resulted cards given five teams one injured player two two one injuries frequent injuries lower limbs muscles strains happened second part second half match acl rupture end first half sprains strains second half contusions occurred times throughout match although seemed concentrated towards end first half cases tendinitis caused first part second half conclusion football injuries common even though serious injuries rare increasingly necessary set protocols action ensure good medical attention levels address problems arise training competitions prepared treat serious injuries occur
background little research regarding ability black men sex men women bmsmw access maintain hiv related health care treatment adherence population often insist secrecy sex desire may experience unique barriers seeking regular care treatment methods march april recruited bmsmw san francisco bay area enrolled randomized controlled trial baseline administered behavioral survey assessing demographics homelessness employment history incarceration hiv status disclosure practices care treatment adherence men reported living hiv intake learn experiences recruited participate qualitative interviews conducted april december topics included current living situation diagnosis story disclosure practices experiences accessing maintaining care treatment hiv related stigma recordings transcribed coded major themes results despite located area treatment plentiful men faced social economic barriers maintaining regular care treatment adherence several findings emerged shed light quandary competing needs particularly around attaining stable housing food security money created barriers treatment care side effects hiv medications discouraged men adhering treatment provider institutional level characteristics influenced care engagement disclosure social support made difference care treatment behaviors participants expressed desire group based intervention activities support treatment care among hiv bmsmw inadequate engagement continuum care hiv born quantitative data participants know viral load conclusions holistic approach hiv health bmsmw would appear translate better outcomes men living hiv goal viral suppression must also include attending basic social economic support needs
inherent broadcast characteristics wireless medium make wireless data transmission difficult shielded unintended recipients secure communication wireless channels becomes critical issue design wireless networks study authors study cooperative jamming power optimisation untrusted relay networks improve physical layer security exploiting direct link source based jamming sbj scheme proposed hinder untrusted relay intercepting confidential message considering total power budget power allocation strategy also proposed optimally determine power source untrusted relay well power information jamming signals furthermore evaluate secrecy performance proposed sbj scheme power allocation strategy tight lower bound ergodic secrecy capacity asymptotic secrecy outage probability derived closed form simulation verifies advantages proposed sbj scheme power allocation strategy
development chemoresistance limits efficiency anticancer agents long major problem cancer therapy urgently needs solved improve clinical outcomes factors contributing chemoresistance various key factor cell capability stress management autophagy favored survival strategy organisms employ get many kinds stress emerging crucial player drug resistance shown autophagy facilitates resistance tumor cells anticancer agents abrogation autophagy could therapeutically beneficial cases suggesting autophagy could promising target cancer treatments thus defining roles autophagy chemoresistance mechanisms involved critical enhance efficiency chemotherapy develop novel anticancer strategy interventions
design data storage abandons abuse traditional database low query efficiency easy maintain long development cycle disadvantage combining xml relational databases data storage satisfies characteristics editor information quantity high speed running electronic patients software module modular development method transplantation adopted electronic patients case editing module ported different medical teaching rescue system software provides software effectively solve contradiction efficiency development efficiency achieve quick easy process becomes stable secure software systems
background individuals dementia may appear court different roles victims witnesses standing rights growing interest rights older persons dementia relatively little empirical data exists regarding actual interactions courts therefore goal study empirically map legal terrain methods study used descriptive quantitative method computerized search national legal database limited period screening process results used establish sample court rulings directly addressed dementia cases analyzed categorized following four criteria groups characteristics person dementia characteristics legal procedure legal substance case legal outcome results majority cases involved single elderly years woman living community unspecified dementia majority cases heard decided lower level courts addressing broad range primarily non criminal legal issues finally majority non criminal cases person dementia found legally capable whereas majority criminal cases person dementia found incapable conclusions legal needs rights persons dementia much broader issues legal capacity social protection deeper knowledge research needed order fully understand contexts dementia constructed law
background studies already proposed inverse association vitamin levels breast density breast density already considered established risk factor breast cancer connection could offer new starting point prevention breast cancer material methods investigate suggested connection total pre post menopausal women mammography indicated recruited cross sectional study addition questionnaire based interview patient general gynecological medical history eating habits lifestyle serum levels hydroxyvitamin calcium phosphate creatinine determined breast density determined mammography categorized according acr classification addition performing descriptive analysis get better overview data number multivariate regression models developed determine impact confounders connection vitamin mammographic density results half participants low levels small minority women currently considered optimal serum levels least significant majority cohort medium mammographic density acr acr logistic regression analysis showed lower serum levels associated significantly often high rather medium breast density association remained even adjusting factors influence breast density age bmi menopausal status acr acr acr acr analysis done separately pre menopausal post menopausal women bmi groups found inversely correlated breast density inverse correlation highly significant post menopausal women age found similarly correlated appear associated acr pre menopausal women opposite case although correlation age breast density higher vitamin levels tended associated lower breast density acr acr smaller sample vitamin rich food food supplements also taken account regular intake vitamin preparations associated lower breast density association achieved borderline statistical significance acr acr analysis also took menopausal status account breast density pre menopausal women lower following regular vitamin intake lower breast density pre menopausal women statistically highly significant acr acr acr respectively effect found post menopausal women frequent intake vitamin containing nutrition significant impact acr either groups conclusion results reinforce assumption previously proposed several authors higher levels pre menopause vitamin substitution associated lower breast density could reduce risk breast cancer findings confirm post menopausal association vitamin mammographic breast density
paper addresses problem identifying different flow environments sparse data collected wing strain sensors insects regularly perform feat using sparse ensemble noisy strain sensors wing first obtain strain data numerical simulation manduca sexta hawkmoth wing undergoing different flow environments data driven method learns low dimensional strain features originating different aerodynamic environments using proper orthogonal decomposition pod modes frequency domain leverages sparse approximation classify set strain frequency signatures using dictionary pod modes bio inspired machine learning architecture dictionary learning sparse classification permits fewer costly physical strain sensors simultaneously robust sensor noise measurement selection algorithm identifies frequencies best discriminate different aerodynamic environments low rank pod feature space manner sparse noisy wing strain data exploited robustly identify different aerodynamic environments encountered flight providing insight stereotyped placement neurons act strain sensors manduca sexta hawkmoth wing
background genetic variation matrix metalloproteinase mmp gene polymorphism suggested modulate coronary heart diseases chd yet underlying mechanisms well understood methods investigated association mmp single nucleotide polymorphism inflammation lipid lowering efficacy simvastatin treatment chinese patients chd fasting serum lipid profile plasma inflammatory mediators determined baseline patients chd healthy control subjects hmg coa reductase inhibitor simvastatin treatment day weeks chd subjects results found plasma mmp tnf alpha levels significantly elevated patients chd compared control subjects treatment plasma mmp chd patients carrying genotypes comparable interestingly chd patients carrying genotype significantly higher level triglyceride low density lipoprotein cholesterol ldl carrying genotype simvastatin treatment significantly reduced ldl plasma inflammatory mediator levels chd patients reduction ldl upon simvastatin therapy significantly greater patients carrying genotype carrying genotype conclusions mmp genotype associated elevated serum ldl enhanced ldl lowering response upon simvastatin treatment chinese patients chd
growing need electrical generation distribution system modern commercial aircraft field aviation trend towards electric aircraft implies substitution hydraulic pneumatic systems electrical ones trend effect results increasing demand energy aircraft construction state art inflexible point point supply loads based complex expensive electric load analysis connecting load different feeders flights possible rigid wiring article introduces modern concepts improving electrical distribution systemnamely feeder balancing phase balancing methods involve utilizing intelligent switching nodes based power semiconductor devices concepts allow reallocation electrical loads different power feeders article also present analysis integration multifunctional fuel cell system focus necessary changes electrical network aircraft less decade time commercial aircraft could use low temperature fuel cells substitute auxiliary power unit ram air turbine used ground phases cases turbine failure using fuel cells could aid constructing completely different layout electrical network implementing voltage level increasing electrical demand aircraft requires energy efficient power supply network copyright john wiley sons ltd
vibration energy exists widely always wasted energy harvesting devices convert kinetic energy electrical energy attracted much interest variety vibration driven generators using electromagnetic principles convert kinetic energy electrical energy studied powering sensors however power supply always bottleneck problem development handheld electronic equipments low power electrical apparatus paper vibration electrical power generator designed magnetic field distribution analyzed using finite element method fem input output model generator built basis vibration equation law electromagnetic induction calculation result shown output voltage generator depends amplitude frequency waveform vibration source generator prototype fabricated tested open circuit different loads resistances inductances capacitances comparison experimental result calculating one shown model describe input output relation vibration electrical power generator
research focused designing interactive products particular process leads conception innovative interfaces interfaces discussed tangible interfaces exploit physicality material characteristics input output mechanisms human product interaction process objective research investigate use interaction design methodologies design smart material interfaces interactive tangible products consisting primarily smart materials overlapping discipline interaction design world smart materials generates new design opportunities thanks overlapping objects daily use become able convey information physical properties use material made communicative medium paper divided three parts first part investigates role materials interaction design second part presents brief research third one reports experimental workshop conducted order elaborate new interactive metaphors lighting design
letter investigated coupling phenomenon dcp inhibited channel potential nand flash memory inhibited channel nand flash structure easily floating state channel directly connected body floating channel behavior adversely affect memory operation specifically program verify operation dcp reduces boosting potential inhibit string consequently insufficient channel potential leads large program disturbance deterioration cell distribution characteristics using computer aided design simulations analyzed phenomenon proposed operation method alleviate phenomenon
despite fact numerous online virtual worlds dvws implemented elearning training platforms mainly academic milieus environments still employed research purposes current practice present paper presents synthetic evaluation experimental online multi user dvw teaching learning computer graphics classes discusses findings results evaluation similar activities performed moodle lms platform paper concludes different aspects usability pedagogical efficacy technology acceptance gives recommendations good practices designing educational dvws
background thyroid hormones associated renal dysfunction cross sectional studies however prospective studies exploring effect thyroid hormones renal function decline sparse got contradictive results aimed prospectively explore associations thyroid hormones incident chronic kidney disease ckd rapid decline estimated glomerular filtration rate egfr chinese adults methods participants community based cohort including individuals aged years without ckd baseline thyroid stimulating hormone tsh free triiodothyronine free thyroxin measured radioimmunoassay baseline serum creatinine urinary creatinine albumin measured baseline follow ckd defined egfr rapid egfr decline defined annual egfr decline min results years follow participants developed ckd experienced rapid egfr decline compared tertile tertile levels associated folds confidence interval increased risk incident ckd folds increased risk rapid egfr decline trend adjustment confounders pmol associated increased risk incident ckd rapid egfr decline among incident ckd individuals significantly associated higher risk concurrent complications outcomes ckd find associations tsh ckd rapid egfr decline conclusions higher tsh associated increased risk incident ckd rapid egfr decline middle aged elderly chinese
impaired manual dexterity frequently reported disability people multiple sclerosis increasingly prevalent worsening disease various tests patient reported outcome measures available nine hole peg test nhpt considered gold standard measure manual dexterity frequently used research clinical practice outcome assessments consortium msoac includes representatives advocacy organizations food drug administration fda european medicines agency ema national institute neurological disorders stroke ninds academic institutions industry partners along persons living among msoac goals acceptance qualification regulators performance outcomes highly reliable valid practical cost effective meaningful persons critical step neuroperformance metrics elucidation clinically relevant benchmarks well defined degrees disability gradients change deemed clinically meaningful article addresses nhpt proposed msoac measure upper extremity function find nhpt reliable within test sessions discriminates healthy subjects patients different levels upper limb impairment shows high convergent validity manual dexterity well comprehensive upper limb measures ecological validity established relation perceived upper limb use daily life perceived difficulty performing activities daily living nhpt responsive deterioration longitudinal studies research suggests change test score commonly used define clinically meaningful worsening definition needs validation stages disease
present study complex anti climacterium potential standardized pomegranate concentrated solution pcs investigated using bilateral ovariectomy ovx female ddy mice changes body weight gain experimental periods food consumption serum estradiol levels total body abdominal fat densities abdominal fat pads uterus weights observed along histopathology abdominal fat pads uterus anti obesity estrogenic effects addition liver weights serum aspartate aminotransferase ast alanine aminotransferase alt levels histopathological inspections performed explore hepato protective effects serum total cholesterol low density lipoprotein ldl high density lipoprotein triglyceride levels monitored hypolipidemic effects total body femur mean bone mineral density bmd right femur wet dry ash weights strength serum osteocalcin bone specific alkaline phosphatase balp contents histological histomorphometrical analyses anti osteoporosis activity result ovx notable increases body weight gains food consumption abdominal fat mass densities weights abdominal fat pads deposited abdominal cavity serum ast alt ldl osteocalcin levels observed along decreases uterus liver femur weights mean total body femur bmd femur strength serum balp estradiol levels addition marked hypertrophic alterations adipocytes located deposited abdominal fat pads liver steatosis uterine disused atrophic changes decreases bone mass structures femur also observed ovx control mice significant increases bone resorption markers based histopathological histomorphometrical analysis however estrogen deficient climacterium symptoms significantly inhibited days continuous treatment estradiol pcs respectively present results suggested pcs able effectively inhibit refine climacterium symptoms including obesity hyperlipidemia hepatic steatosis osteoporosis induced ovx ddy mice
graph theory plays many important roles modern physics many different contexts spanning diverse topics description scale free networks structure universe complex directed graph causal set theory graph theory also ideally suited describe many concepts computer science therefore increasingly important physics students master basic concepts graph theory describe student project develop computational approach electric circuit solving based graph theoretic concepts highly multidisciplinary approach combines abstract mathematics linear algebra physics circuits computer programming reach ambitious goal implementing automated circuit solving
background somatic calreticulin calr janus kinase jak thrombopoietin receptor mpl mutations essentially show mutual exclusion myeloproliferative neoplasms mpn suggesting activate common oncogenic pathways recent data shown mpl function essential calr mutant driven mpn however exact role mechanisms action calr mutants fully elucidated methods murine myeloid cell line human cells overexpressing frequent calr type type frameshift mutants generated analyze first steps cellular transformation presence absence mpl expression furthermore mutant calr protein stability secretion examined using brefeldin spautin tunicamycin treatment results present study demonstrates expression endogenous mpl key megakaryocytic transcription factor stimulated type type calr mutants even absence exogenous mpl mutant calr expressing cells spontaneously acquired cytokine independence associated increased mpl mrna expression protein well constitutive activation downstream signaling response jak inhibitor treatment exogenous expression mpl led constitutive activation stat erk akt cytokine independent growth reduction apoptosis similar effects seen spontaneously outgrown cells observed low calr mutant protein amounts cellular lysates stably transduced cells due accelerated protein degradation occurred independently ubiquitin proteasome system well autophagy calr mutant degradation attenuated mpl expression interestingly found high levels mutated calr loss downstream signaling blockage secretory pathway protein glycosylation conclusions findings demonstrate potency calr mutants drive expression megakaryocytic differentiation markers well mpl furthermore calr mutants undergo accelerated protein degradation involves secretory pathway protein glycosylation
many species family paridae marsh tits poecile palustris large scale scatter hoarders food make cryptic caches disperse large year round territories perhaps well known species family great tit parus major store food skilled stealing caches species previously demonstrated great tits able memorise positions caches observed marsh tits make later return steal food great tits explorative nature unusually good learners possible memorisation caches distance unique ability possibility ability general parid family tested marsh tits experimental set previously tested great tits allowed caged marsh tits observe caching conspecific specially designed indoor arena retention interval allowed observer enter arena search caches marsh tits showed evidence observational memorization ability believe ability useful non hoarding species marsh tit memorises hundreds caches field bother difficult task memorising individuals caches argue close memorisation procedure marsh tits use caches may different type observational learning memorisation caches made others example latter must done distance hence may require ability adopt allocentric perspective ability visualise cache hoarder perspective significance statement members paridae family known possess foraging techniques cognitively advanced previously demonstrated non hoarding parid species great tit major able memorise positions caches observed marsh tits palustris make however unknown whether cognitively advanced foraging strategy unique great tits occurs also parids demonstrated pilfering observational memorization strategy general strategy parids believe ability important non hoarding species great tit likely birds owning many caches need foraging strategy
background canadian wait time data available treatment cancer heart disease well joint replacement cataract surgery diagnostic imaging procedures wait times gastroenterology consultation procedures studied although digestive diseases pose greater economic burden canada cancer heart disease methods specialist physicians completed practice audit provided digestive health care accepted new patients recorded referral dates patients seen consultation investigation one week period preprogrammed personal digital assistants used collect data including main reason referral initial referral consultation dates procedure dates performed personal family history patient symptoms signs test results patient triaging appropriateness referral timeliness care noted results months physicians recorded details referrals including visits procedures distribution total wait times referral procedure nationally highly skewed days median percentile substantial interprovincial variation british columbia days alberta days ontario days quebec days new brunswick days nova scotia days percentage physicians province offering average risk screening colonoscopy varied discussion access specialist gastroenterology care canada limited long wait times exceed clinically reasonable waits specialist treatment although exhibiting methodological limitations large practice audit sampling offers broadly generalized results well means identify barriers health care delivery evaluate strategies address barriers goals expediting appropriate care patients digestive health disorders ameliorating personal societal burdens imposed digestive diseases
prenatal environment recognized key driver non communicable disease risk later life within developmental origins health disease dohad paradigm studies increasingly identifying links maternal morbidity pregnancy disease later life offspring nutrient restriction metabolic disorders gestation diabetes obesity maternal immune activation provoked infection linked adverse health outcomes offspring later life factors frequently occur potential compounding effects multiple morbidities dohad related outcomes received adequate attention particular importance low middle income countries lmics ongoing high rates infectious diseases experiencing transitions undernutrition excess adiposity purpose scoping review summarize studies examining effect interaction occurring metabolic nutritional stressors infectious diseases gestation dohad related health outcomes identified nine studies humans four performed united states five lmics common outcome also seven nine studies premature birth low birth weight identified nine animal studies six mice two rats one sheep interaction metabolic nutritional exposures infectious exposures varying effects including synergism inhibition independent actions human studies specifically designed assess interaction metabolic nutritional exposures infectious diseases future studies neonatal outcomes measure exposures explicitly examine concerted effect
present efforts improve maize performance water limited environments aggressively pursuing leaf level traits quantum efficiency mesophyll osmoregulation stress protein responses however possible improvement traits lead directly hydraulic failure hydraulics photosynthesis closely aligned address whole plant response drought stress ask photosynthetic hydraulic traits appear bundled together coordinated response traits operate largely independently one another xylem conductance leaves stems whole plant conductance stomatal conductance rate electron transport etr maximal catalytic rate phosphoenolpyruvate carboxylase pmax net assimilation amax measured maize plants subjected contrasting levels drought stress greenhouse field experiments photosynthetic traits max etr pmax hydraulic traits whole plant stem conductance stomatal conductance reduced leaf water potentials declined mpa furthermore variation associated photosynthetic hydraulic traits measured study explained single principal component revealing remarkable degree alignment among whole plant transpiration rates recovered maximal values lifting severe drought stress leaf leaf mpa closely aligned hydraulic photosynthetic stomatal responses drought stress suggest improvements individual traits isolation may lead loss plant functioning water transport rather leading marked improvements growth published elsevier gmbh
legislation united states child abuse prevention treatment act individuals disabilities education improvement act mandates service system collaboration meet complex needs young children disabilities experienced abuse literature review examines extant literature related young children disabilities experienced abuse gaps literature identified future directions discussed
background economic evaluation palliative care slow develop evidence base remains small aim article estimates formal informal care costs last year life sample patients received specialist palliative care three different areas ireland design formal care costs calculated community specialist palliative care acute hospital services possible bottom approach used multiplying service utilisation unit cost informal care valued replacement cost care setting participants data utilisation collected death telephone interviews person centrally involved care last year life decedents received specialist palliative care three areas ireland varying levels specialist palliative care results mean total formal informal costs last year life vary significantly across three areas components formal costs however vary across areas particularly hospital specialist palliative care last months life conclusion costs last year life patients receipt specialist palliative care considerable inpatient hospice care available potential savings hospital costs offset specialist palliative care inpatient costs informal care accounts high proportion costs last year life area underlining important role informal caregivers palliative care
masticatory apparatus highly adaptive musculoskeletal complex comprising several relatively independent structural components assist functions including feeding breathing hypothesized tongue elemental maintenance normal ontogeny mandible post natal growth development tested using morphometric approach assessed tongue mandibular measurements male human cadavers landmark lingual mandibular data gathered individuals aged gestational weeks postnatal analysis geometric morphometrics assisted visualizing morphometrical growth changes mandible tongue linear correlation conjunction principal component analysis visualized growth relationship structures found growth tongue mandible intrinsically linked size shape gestational weeks months postnatal however mandible continued change shape size life whereas tongue increased size period time findings provide valuable insights allometric growth relationship structures potentially assisting clinician predicting behaviour structures assessment malocclusions
forest roads necessary element accessing forestry resources impact environment significant forest roads cause variety impacts local wildlife may lead extirpation facilitating spread invasive organisms causing death harm vehicle strikes changing behavior animals detriment roads create improved access forests increase predation rates hunters animals may move avoid traffic noise increasing vulnerability predation animals one significant impacts forest roads water quality catastrophic chronic sources water pollution primarily sediment case every road cause impacts mitigation measures used lessen negative effects mitigation measures must begin location phase road continue construction use maintenance roads application mitigation measures allows forest managers minimize impacts forest roads necessary
biologic therapies emerging significant therapeutic option many debilitating inflammatory autoimmune conditions expansion number fda approved agents continue seen unanticipated adverse reactions likely occur currently diagnostic tools including skin testing vitro testing evaluate immediate hypersensitivity reactions insufficient review management strategies common acute infusion reactions injection site reactions immediate reactions suggestive ige mediated mechanisms discussed desensitization considered reactions suggestive ige mediated mechanisms allergists immunologists involved managing patients
outcome studies rheumatic diseases report outcomes ascertained single occasion single assessments sufficient terminal irreversible outcomes may sufficiently informative outcomes change fluctuate time consequently longitudinal studies measure non terminal outcomes repeatedly afford better understanding disease evolution longitudinal studies require special analytic methods newer longitudinal analytic methods evolved tremendously deal common challenges longitudinal observational studies recent years increasing number studies used longitudinal design review aims help readers understand apply findings longitudinal studies using cohort children juvenile dermatomyositis jdm illustrate study evolution disease activity jdm using longitudinal methods
background constipation uncomfortable common condition affects many irrespective age since health care practitioners provided treatments prevention strategies patients chronic constipation despite significant variation medical personal perceptions condition objective review relevant research evidence clinical studies investigating efficacy safety commercially available pharmacological laxatives canada emphasis studies adopting rome criteria defining functional constipation search methods pubmed medline embase evidence based medicine reviews databases searched blinded randomized clinical trials meta analyses assessing efficacy nonstimulant stimulant laxatives treatment functional constipation results total clinical studies four meta analyses retrieved abstracted regarding study design participants interventions outcomes majority studies focused polyethylene glycol compared placebo nonstimulant stimulant laxatives provided better relief constipation symptoms placebo according objective subjective measures one study compared efficacy nonstimulant versus stimulant laxative two reported changes quality life studies reported minor side effects due laxative use regardless treatment duration ranged one week one year laxatives well tolerated adults children
study examined validity micro social observations macro ratings parent child interaction early middle childhood seven hundred thirty one families representing multiple ethnic groups recruited screened risk context women infant children wic nutritional supplement service settings families randomly assigned family checkup fcu intervention control condition age videotaped structured interactions home ages parent child interaction videotapes micro coded using relationship affect coding system racs captures duration two mutual dyadic states positive engagement coercion macro ratings parenting skills collected coding videotapes assess parent use positive behavior support limit setting skills lack thereof confirmatory factor analyses revealed measurement model macro ratings limit setting positive behavior support supported data thus excluded analyses however moderate stability families micro social dynamics across early childhood showed significant improvements function random assignment fcu moreover parent child dynamics predictive chronic behavior problems rated parents middle childhood emotional problems conclude discussion validity racs methodological advantages micro social coding statistical limitations macro rating observations future directions discussed observation research prevention science
several clinical biological features lymphoproliferative diseases associated increased risk developing autoimmune manifestations acquired deficiency inhibitor inh aae rare syndrome clinically similar hereditary angioedema hae characterized local increase vascular permeability angioedema skin gastrointestinal oro pharyngo laryngeal mucosa bradykinin potent vasoactive peptide released high molecular weight kininogen cleaved plasma kallikrein serine protease controlled inh mediator symptoms total aae patients carry underlying hematological disorder including monoclonal gammopathy uncertain significance mgus cell malignancies however aae patients anti inh autoantibodies without hematological clinical instrumental evidence lymphoproliferative disease unlike hae patients aae patients usually late onset symptoms family history angioedema present variable response treatment due hypercatabolism inh experiments show inh classical complement pathway consumed neoplastic lymphatic tissues anti inh neutralizing autoantibodies therapy aae follows two directions prevention reversal symptoms angioedema treatment associated disease different forms cell disorders coexist evolve aae seem dominated altered control cell proliferation thus aae represents example strict link autoimmunity lymphoproliferation
great part human communication carried nonverbally information lost mobile text messaging work describes attempt augment text chatting mobile phones adding automatically detected facial expression reactions conversations expressions detected using known image processing techniques known related work concerning investigation non verbal communication text messaging considered distinguished present solution conception implementation mobile phone application debated feature described user studies narrated finally context application conclusions future work also discussed
article introduces educational functions computer program developed put practice computer aided instruction finite element method interactive simulation graphical visualization used tool teach learn concepts procedures related construction solution finite element stiffness equations tool encompasses stages processing finite element equations element modeling equation solving operation educational tool emulation computational processes actual execution finite element processing thus instructors finite element method may use educational program tool present complex computational aspects comprehensible graphic images students may experience explore stage computation using interactive simulation attain better understanding concepts procedures stiffness method bypassing manual calculation computer programming instructional tool implemented part finite element analysis program wiley periodicals inc comput appl eng educ view article online doi
objectiveto compare two approaches measuring racial ethnic disparities use high quality hospitals data sourcessimulated data study designthrough simulations compared minority serving approach assessing differences risk adjusted outcomes minority serving non minority serving hospitals fixed effect approach estimated reduction adverse outcomes distribution minority white patients across hospitals evaluated method ability detect measure disparity outcomes caused minority patients receiving care poor quality hospitals label hospital disparity reject disparity outcomes caused factors hospital quality principal findingsthe minority serving fixed effect approaches correctly identified hospital disparities quality existed rejected racial differences outcomes caused disparities however fixed effect approach many advantages require hoc definition minority serving hospital estimated magnitude disparity accurately minority serving approach underestimated disparity percent conclusionsresearchers consider using fixed effect approach measuring disparities use high quality hospital care vulnerable populations
neurologic complications decompression sickness observed half century little known however risk diving patients suffer migraine aura mwa report case pediatric patient history migraine aura later found pfo developed headache neurological symptoms scuba diving lesson
previous research attributed right hemisphere key role eliciting false memories visual emotional stimuli results explained terms two right hemisphere properties emotional stimuli preferentially processed visual stimuli represented coarsely according account false emotional memories preferentially produced emotional stimuli strongly diffusely activated encoding leaving memory trace erroneously reactivated similar unstudied emotional items test right hemisphere hypothesis correct damage result reduction false memories emotional stimuli relative left hemisphere lesions investigate possibility groups right brain damaged rbd left brain damaged lbd healthy participants took part recognition memory experiment emotional negative positive non emotional pictures false memories operationalized incorrect responses unstudied pictures similar studied ones rbd lbd participants showed similar reductions false memories negative pictures relative controls positive pictures however false memories reduced rbd patients results provide partial support right hemisphere hypothesis suggest inter hemispheric cooperation models may necessary fully account false emotional memories elsevier inc rights reserved
compared conventional order hypocritical actionssaying one thing anothermerely reversing order actions mitigate whether individual judged hypocrite barden rucker petty present research examines factors extraneous target actionsspecifically group membershipinfluence hypocrisy judgments three experiments provided consistent evidence reversing order statement behavior mitigated hypocrisy judgments greater extent observers judged ingroup targets compared outgroup targets pattern observed across two distinct groups gender political party addition mediational evidence suggested greater mitigation ingroup targets stemmed observer greater tendency make attributions ingroup targets genuinely changed better
spatial organization extensively studied field research physical environment perceived conceived consensus physical attributes environment geometry landmarks key factors shaping spatial cognition nevertheless numerous studies spatial behavior usually carried individuals thereby overlooking possible impact social environment present study rats exposed unfamiliar open field first alone tetrads unfamiliar individuals order monitor analyze individual spatial behavior converged group spatial behavior found unfamiliar rats spent time companionship first preferred partners ultimately quartet specifically group formation dynamic gradual rats first forming duos trios ultimately quartet trios quartets mostly huddled specific corner became shared home base took solo duo roundtrips arena present study unveils means gradual interactions among self place conspecifics four unfamiliar rats organized together social spatial behavior
background large body evidence supports central role tlr natural ligand flagellin crohn disease precise mechanism still unresolved methods investigated role flagellin tlr samp yitfc samp mice spontaneous model crohn disease like ileitis results ileal tlr serum antiflagellin igg antibodies increased samp onset inflammation established disease trends abrogated absence colonizing commensal bacteria irradiated samp receiving either wild type akr samp bone marrow developed severe ileitis displayed increased ileal tlr compared akr recipients either samp akr bone marrow neither conferred ileitis suggesting elevated tlr native samp derived primarily nonhematopoietic epithelial source indeed ileal epithelial tlr preinflamed samp increased compared age matched akr germ free samp tlr specific vivo activation samp ileal tissues decreased epithelial barrier resistance indicative increased permeability accompanied altered expression tight junction proteins claudin occludin zonula occludens conclusions results provide evidence aberrant elevated tlr expression present ileal epithelium samp mice augmented presence gut microbiome tlr activation response bacterial flagellin results deficiency maintain appropriate epithelial barrier integrity together findings represent potential mechanistic pathway leading exacerbation perpetuation chronic gut inflammation experimental ileitis possibly patients crohn disease
recent studies regarding effect mood drm deese roediger mcdermott illusion able clearly establish yet whether valence arousal critical determining susceptibility false memories underlying processes three experiments valence level arousal participants mood manipulated six conditions used positive mood high low arousal negative mood high low arousal neutral mood control condition memory tested means immediate delayed recognition immediate free recall mood induction procedure effective recognition memory effect arousal endorsement critical lures low arousal moods elicited false recognition high arousal moods regardless valence based signal detection analyses effect attributed liberal response criteria low arousal combination tendency towards improved item specific memory high arousal
increase power demand required providing infrastructure huge power plants transmission lines however recent trends power system planning operation toward maximum utilization existing electricity infrastructure tight operating margins new constraints placed economic political environmental issues might cause serious stability problems severe fault sudden outage critical lines occurs therefore special protection scheme sps used generator tripping successive load shedding prevent large scale blackout cascading effect number tripping generators sps operation reduced enormous cost power outage saved paper analyzes enhancement sps via transient stability improvement static synchronous compensator statcom applied generation side korea electric power system first characteristic related sps described proper capacity statcom determined equal area criterion reduce number tripping generators also new control method statcom proposed full utilization finally effectiveness verified case study practical data korea electric power system
psychological health children global health concern international health behavior school aged children hbsc study surveyed psychological health youths countries hbsc questionnaire includes brief symptom checklist psychological complaints yet validated study evaluated construct validity psychological health self report tool used hbsc study used data participants canadian hbsc survey core hbsc questionnaire measured common psychosomatic complaints using hbsc symptom checklist hbsc scl canadian survey included additional series questions measure four dimensions mental health emotional problems emotional well behavioral problems prosocial behavior used items evaluate construct validity psychological symptoms hbsc scl assessed internal construct validity using cronbach alpha external construct validity using factor analysis structural equation modelling factor analysis showed hbsc scl measures two factors psychological somatic complaints psychological complaints included feeling low depressed irritable bad tempered nervous difficulties sleeping internal validity psychological subscale good alpha item subscale demonstrated convergent validity indicators emotional problems correlation emotional well discriminant validity indicators behavioral problems prosocial behavior results support hbsc scl psychological subscale valid measure psychological health school aged children future research recommended replicate findings youth populations
recently bacterial foraging optimization algorithm great interest global optimization industrial control escherichia coli social foraging behaviour inspiration bfoa bfoa efficient solving real world optimization issues various domains coli biological behaviour exhibiting foraging emulated optimization algorithm called bfoa hence well suited marine application chemotaxis step bfoa analysed using mathematical model analysing lead adaptive variant bfoa chemotactic step size varied accordance current fitness virtual bacterium
article identifies trends impact applying information communication technologies ict blended learning educational model also known blended learning proposes make integration virtual face face oriented classes classrooms research taken account results experiences different educational areas emphasizing mediation ict blended learning achieved great impact thanks interaction teachers students generating positive results teaching learning process methodological aspects used blended learning based use ict develop online virtual activities allow participant develop cognitive competitive critical constructive thinking skills problem solving systematic review literature importance use ict within methodology acknowledged allows dynamic adjustable learning process making pioneer educational environments great effectiveness interaction
empathy fundamental interpersonal relationships therapy theoretical dissensus underlying process study investigated lived experience understanding another person innovative combination qualitative methods design involved making video recordings interpersonal interactions pairs volunteers recordings used day cued recall interview interview volunteers asked discuss interaction experiences four depth case studies involving eight participants conducted using technique interviews subjected interpretative phenomenological analysis results illuminate multi dimensional characteristics interpersonal understanding namely understanding another person experienced phenomenon three main aspects intuitive shared sympathetic imaginative intellectual interestingly shared sympathetic imaginative intellectual understandings strongly connected insights accessed via verbal communication self based understandings hand intuitive understandings typically linked nonverbal communication domain based intersubjective pre reflective forms understanding argue intuitive understandings represented empathy literature acknowledged important experiential component phenomenon distinguished intellectual sympathetic understandings
teams deliver complex transportation construction projects need tools manage risk allow successful delivery construction manager general contractor project delivery alternative method furnishes public agencies attractive option delivering projects less adversarial constructive manner involving contractor design phase paper identifies effects delivery construction process risk owners contractors design engineers sizable experience transportation related projects surveyed identify differences perception processes especially compared design build design bid build project delivery methods perceived benefits disadvantages regarding quality schedule cost control collaboration flexibility discussed benefits include strategies robust process risk management successful project delivery disadvantages expose barriers implementation must overcome ultimately research identifies differences project teams value processes regard minimizing construction process risk thus enabling teams effectively facilitate unity strengthen process american society civil engineers
objective intimate partner violence ipv pregnancy serious health consequences mothers newborns aim study explore influence experiencing ipv pregnancy delayed entry prenatal care whether women decision making autonomy support traditional gender roles act mediate moderate relationship ipv delayed entry prenatal care design cross sectional survey multivariate logistic regression models estimated control various socio demographic pregnancy related factors assess whether women experienced ipv pregnancy likely delay entry prenatal care compared women experienced ipv influence traditional gender roles acceptance decision making autonomy examined independent variables interaction ipv assess role potential mediators moderators setting chandpur district bangladesh participants sample comprised bangladeshi women aged years postpartum mothers visited vaccinations centres receive children vaccinations constitute sampling frame results almost women surveyed reported patterns consistent delayed entry prenatal care accounting influence covariates women experienced physical ipv pregnancy times likely delayed entry prenatal care counterparts report physical ipv neither sexual psychological ipv victimization pregnancy linked late entry prenatal care gender role attitudes levels autonomy mediate effect ipv prenatal care key conclusions results suggest high rates ipv bangladesh effects compromise women health seeking behaviour pregnancy putting developing fetus risk specifically bangladeshi women experience physical ipv pregnancy likely delay forgo prenatal care effect magnified cultural ideals emphasize women traditional roles limit autonomy implications practice study reinforces need detect assist women suffering ipv offer help support also increase entry prenatal care healthcare professionals involved obstetrics midwifery need aware risk factors ipv pregnancy able identify women risk delayed entry prenatal care
compared hydrodynamics replicate experimental mixed cell replicate standard burrows pond rearing systems dworshak national fish hatchery effort identify methods improved solids removal measured compared hydraulic residence time particle removal efficiency measures velocity using several tools computational fluid dynamics used first characterize hydraulics proposed retrofit included removal traditional burrows pond dividing wall establishment four counter rotating cells appropriate drains inlet water jets hydraulic residence time subsequently established four full scale test tanks using measures conductivity salt tracer introduced systems without fish present vertical horizontal velocities also measured acoustic doppler velocimetry transects across rearing systems finally introduced abs sinking beads simulated fish solids followed kinetics removal via drains establish relative purge rates mixed cell raceway provided higher mean velocities uniform velocity distribution burrows pond vectors revealed well defined counter rotating cells mixed cell raceway likely contributing factors achieving relatively high particle removal efficiency versus test period speculate retrofits rearing ponds mixed cell systems improve rearing environments fish solids removal improving efficiency bio security fish culture recommend testing hatchery production trials evaluate fish physiology growth published elsevier open access article license
proposed study first time sensitive electrochemical detection breast cancer biomarker microrna mirna mir achieved via electropolymerized polypyrrole ppy modified pencil graphite electrodes ppy pge detection hybridization electrochemically doped probe mirna antimir complementary target mir monitored either electrochemical impedance spectroscopy eis via comparison charge transfer resistance rat values hybridization electrochemical reduction signal hybridization indicator meldola blue mdb study covers optimization steps hybridization procedure electropolymerization pyrrole well detection real samples breast cancer cell line mcf designed sensor shows high selectivity low detection limit thanks electrical conductivity porous structure ppy
natural situations speech perception often takes place concurrent execution cognitive tasks listening viewing visual scene execution dual task typically detrimental effects concurrent speech perception exactly cognitive load disrupts speech encoding still unclear detrimental effect speech representations may consist either general reduction robustness processing speech signal noisy encoding alternatively may specifically influence temporal sampling sensory input listeners missing temporal pulses thus underestimating segmental durations shrinking time present study investigated whether spectral temporal cues precursor sentence processed high low cognitive load influence perception subsequent target word cognitive load effects implemented noisy encoding increasing cognitive load precursor attenuate encoding temporal spectral cues hence reduce contextual effect cues subsequent target sound perception however cognitive load effects expressed shrinking time context effects modulated load main effect would expected perceived duration speech signal results two experiments indicate increasing cognitive load manipulated secondary visual search task modulate temporal experiment spectral context effects experiment however consistent main effect cognitive load found increasing cognitive load precursor induced perceptual increase perceived speech rate biasing perception following target word towards longer durations finding suggests cognitive load effects speech perception implemented via shrinking time line temporal sampling framework addition argue results align model early spectral temporal normalization unaffected attention later adjustments may attention dependent elsevier inc rights reserved
aimthe aim paper review literature effect lower urinary tract symptoms luts sexual function dysfunction methodsat international consultation incontinence research society ici multidisciplinary group presented literature search known effect lower urinary tract dysfunction lutd sexual function men women wider discussions regarding knowledge gaps ideal research methodology ensued resultsa body evidence supports associations luts urinary incontinence men women true prevalence impact lutd remains largely unknown still reluctance among health care professionals hcp discuss patients often patients asked volunteer problems conclusiona significant knowledge gap area remains education among hcp assessment treatment sexual dysfunction communication skills essential encourage engage patients hcp neurourol urodynam wiley periodicals inc
objective describe spectrum work related injury evaluated rural population methods based injury surveillance system edbiss used collect injury data patients seen year period patient classified injured record contained log injury code icd code diagnostic field code entry trauma registry injury considered work related patient reported injury occurred work results work related injuries accounted injuries mean age patients injured job years range years compared mean age years injured patients males accounted work related injury visits compared injury visits common mechanisms work related injuries overexertion cut pierced sharp implements falls struck object transportation related injuries sprains strains common type injury sustained followed wounds upper limbs contusions fractures patients presenting occupational injuries presented via ambulance treated released remainder hospitalized mechanisms injury commonly resulted hospitalization included struck object transportation falls crushing mechanism machinery requiring hospitalization male average length stay days four hospitalized persons died work related injuries known medical charges incurred patients injured work high average charge treated released average charge required hospitalization conclusions occupational injuries contribute significantly overall incidence injuries seen responsible significant medical charges year
individual differences attentional control involve ability voluntarily direct shift sustain attention studies role attentional control emotional adjustment social relationships vulnerability effects stress self report questionnaires commonly used measure construct yet convincing evidence association self report scales actual cognitive performance demonstrated across independent samples examined associations self reported attentional control attentional control scale acs self reported emotional adjustment five factor model personality traits neo personality inventory revised performance measures attentional control study examined behavioral performance attention network test ant fan mccandliss sommer raz posner modified switching task mst suchy kosson large sample healthy young adults study examined behavioral performance standardized neuropsychological tests attention including conner continuous performance test subtests wechsler adult intelligence scales third edition wais iii psychological corporation delis kaplan executive function system kefs delis kaplan kramer results indicated acs largely unrelated behavioral performance measures attentional control significantly associated emotional adjustment neuroticism conscientiousness findings suggest although self reported attentional control may useful construct researchers using acs exercise caution interpreting proxy actual cognitive ability performance
study novel idea storing latent heat condensing vapor solar stills means phase change materials pcms thermal storage experimentally investigated daytime generated water vapor solar energy conducted external condenser filled pcm condensed wasted latent heat absorbed pcm thereby stored worth noting direct contact saline water pcm therefore solar energy directly stored pcm evening energy stored pcm transferred heat saline water heat pipes enables desalination process continue several tests run investigate performance system results revealed presence external condenser filled pcm equipped heat pipes solar still evacuated tube collectors makes desalination process continue sunset without causing decrease yield daytime yield increases compared yield system without pcm reaches day efficiency elsevier rights reserved
background cell therapy holds promising acute chronic deleterious respiratory diseases however safety tolerance lung disorders controversy methods undertook systematic review meta analyses clinical studies cell therapy outcomes odds ratio risk difference peto relative risk mean difference serious adverse events results systemic infusions bronchial instillations recipients cells analyzed acute respiratory distress syndrome ards bronchopulmonary dysplasia pulmonary arterial hypertension silicosis sarcoidosis extensively drug resistant tuberculosis chronic obstructive pulmonary diseases copd idiopathic pulmonary fibrosis frequency death adults causes per cell therapy controls respectively significant difference found ards copd frequency deaths non fatal serious adverse events open studies similar randomized controlled trials moreover serious adverse events allogenic cells greater autologous preparations shown frequency conclusions conclude either infusion instillation mesenchymal stem stromal progenitor cells well tolerated without serious adverse events causally related cell treatment cell therapy associated significant changes spirometry immune function cardiovascular activity quality life
purpose growing movement counter otc oral contraceptive united states study aimed explore women views regarding age restriction otc methods november december administered nationally representative survey women aged years risk unintended pregnancy explore opinions age restriction otc total women completed survey weighted proportions calculated logistic regression used identify covariates associated supporting age restriction chi square tests potential advantages disadvantages otc access ocs support age restriction also performed results overall respondents supported age restriction otc age restriction unsure multivariable analysis controlling overall support otc access ocs covariates women likely support age restriction otc less high school degree odds ratio high school degree college compared college degree married compared never married lived midwest south compared west conclusions minority women support age restriction women concerns potential otc addressed education ongoing research society adolescent health medicine rights reserved
objective aim study determine whether institution modern management strategy affected pregnancy outcomes intrahepatic cholestasis pregnancy icp methods performed retrospective cohort study women diagnosed icp one hospital new management protocol icp instituted women total bile acids mol atmol diagnosis weeks patient demographics similar groups exception greater maternal age gestational diabetes newer cohort newer cohort demonstrated significant reduction incidence stillbirth versus difference age delivery cesarean delivery rates nicu admissions conclusion application management strategy icp reduced stillbirth rate without adversely affecting maternal neonatal outcomes
pediatric inflammatory bowel disease autoimmune disease causes chronic inflammation gastrointestinal mucosa emerging evidence brain gut connection affects inflammatory bowel disease ibd patients previously thought evidenced comorbid mood disorders irritable bowel symptoms concurrent quiescent ibd potential psychosocial stressors trigger ibd flares mind body interventions psychotherapy relaxation mindfulness biofeedback yoga clinical hypnosis offer adjunct standard medical treatment ibd review current evidence base mind body interventions treatment pediatric ibd illustrate case study offer suggestions future research promising field
paper presents design short term duty electrical machine working extreme environment consisting degrees ambient temperature altitudes higher power density key factor design wherein machine operation required short duty requirement high power weight power volume leads permanent magnet machine design optimized different slot pole combinations concentrated distributed winding arrangements considered optimization genetic algorithm used analytical electromagnetic thermal models adopted together finite element methods shown adopted thermal model provides sufficient accuracy predicting temperature rise within winding also shown designs thermally limited pole numbers limited volt amps drawn converter design consisting high slot number allows improving heat dissipation machine thus weight minimized given torque production
investigation paper coherently coupled nonlinear schrodinger system describes propagation polarized optical waves isotropic medium virtue darboux transformation new solutions generated vanishing non vanishing backgrounds including multi solitons bound solitons one breathers bound breathers two breathers first order higher order rogue waves dynamic behaviors solitons breathers rogue waves discussed graphic simulation
objective phenotyping algorithms capable accurately identifying patients specific phenotypes within electronic medical records systems however developing phenotyping algorithms scalable way remains challenge due extensive human resources required paper introduces high throughput unsupervised feature selection method improves robustness scalability electronic medical record phenotyping without compromising accuracy methods proposed surrogate assisted feature extraction safe method selects candidate features pool comprehensive medical concepts found publicly available knowledge sources target phenotype international classification diseases ninth revision natural language processing counts acting noisy surrogates gold standard labels used create silver standard labels candidate features highly predictive silver standard labels selected final features results algorithms trained identify patients coronary artery disease rheumatoid arthritis crohn disease ulcerative colitis using various numbers labels compare performance features selected safe previously published automated feature extraction phenotyping procedure domain experts sample area receiver operating characteristic curve score safe algorithms remarkably higher two especially small label sizes conclusion safe advances high throughput phenotyping methods automatically selecting succinct set informative features algorithm training turn reduces overfitting needed number goldstandard labels safe also potentially identifies important features missed automated feature extraction phenotyping experts
run river ror hydropower schemes undergone recent resurgence europe legislation requiring protection enhancement physical ecological condition european rivers need understand impacts schemes paper presents assessment eco hydraulic impact ror hydropower scheme peak district national park due ponded nature depleted stretch study site paper focuses characterization hydraulic impact water abstraction ror scheme hydropower outlet samples microhabitats benthic macroinvertebrates within hydraulically affected zones measurement hydraulic transects shows scheme operation notably alters river channel hydraulics water depth whilst impacts much less distinct close proximity river bed identify eco hydraulic relationships benthic macroinvertebrate communities localized near bed velocity turbulence conditions thus indicating potential water abstraction ror schemes impact lower trophic levels riverine ecosystems however spatial patch scale meso habitat comparisons invertebrate communities around hydropower outlet showed subtle differences suggesting case benthic communities minimally impacted ror scheme authors river research applications published john wiley sons ltd
objective characterize management outcomes life threatening laryngeal attacks hereditary angioedema hae treated icatibant observational icatibant outcome survey nct registry methods retrospective analysis based data patients hae type received healthcare professional administered self administered icatibant treat laryngeal attacks september may results twenty centers seven countries contributed data overall patients hae experienced icatibant treated laryngeal attacks icatibant selfadministered attacks healthcare professionaladministered one icatibant injection used attacks rescue concomitant medication used median time treatment attacks median time resolution attacks conclusions analysis describes successful use icatibant treatment laryngeal hae attacks real world setting copyright wolters kluwer health inc rights reserved
airports ask environmental social economic sustainability instances core project development project design must focus role sustainability taking account new performance classes face higher levels building resilience changing climate effects airports need adopt long term strategic approach address need adaptation climate change mitigation impacts environment require new designs materials future airport infrastructure retrofitting existing ones paper reports ongoing research analysis broad study focused evaluation project compliance green building requirements definition technological strategies climate change adaptation correct identification evaluation climate sensitivities enable prioritize adaptive responses also creates new opportunities airport authorities operators anticipate consequences project changing conditions operation using sustainable strategies enhance building resilience european international airports examples case studies presented paper order illustrate good practices methods already adopted assessing minimising risk climate change formulate proposal design airports future
paper develops method based genetic algorithm reliability based optimization rbo structures software application method employs optimization technique reliability constraints rbo problem evaluated using finite element reliability analysis modules offered opensees since tcl programmable interpreted language proposed method implemented using tcl scripting language together opensees software framework developing rbo method software application leads important advantage utilizing new advanced structural reliability methods implemented opensees without compiling source code rbo problem cost design defined objective function number design requirements defined reliability constraints method also able deal rbo problems discrete continuous design variables six numerical examples provided investigate strengths method software application results illustrate advantages application rbo structures since opensees used finite element reliability analysis application readily extendable nonlinear structures elsevier rights reserved
paper addresses problem robust infinity filtering design uncertain markov jump systems mjss mode dependent quantized output partly unknown transition probabilities data transmission exchange completed digital communication channel system outputs need quantized transmission attention mainly concentrated tackling parameter uncertainty unknown transition probabilities output quantization parameter uncertainty considered paper assumed norm bounded exact information transition probabilities matrix partly unavailable quantization error output transformed bounded nonlinearity via model transformation mode dependent filter designed ensure filtering error system stochastically stable noise attenuation performance index finally simulation results provided illustrate validity proposed results elsevier rights reserved
results ccd observations double multiple stars made telescope bulgarian national astronomical observatory rozhen five nights presented ninth series measurements ccd frames obtained rozhen also present results ccd observations double multiple stars made telescope serbian astronomical station mountain vidojevica nights fourth series measurements ccd frames obtained station paper contains results position angle angular separation pairs residuals pairs published orbital elements linear solutions angular separations range median angular separation also present eight pairs measured first time linear elements five pairs
paper maximum sensitivity internal model control imc based proportional integral derivative pid controllers designed unstable first order plus dead time ufopdt processes designed controller parameters functions ufopdt model parameters imc closed loop tuning parameter tuning parameter plays vital role determines closed loop performance robustness designed controller systematic guidelines provided selection tuning parameter based maximum sensitivity analytical tuning rules developed controller parameters different time delay time constant ratios desired level robustness controller settings allow operator deal closed loop control system performance robustness trade specifying robustness level maximum sensitivity simulation studies carried various ufopdt processes explain advantages proposed analysis institution chemical engineers published elsevier rights reserved
fusarium head blight fusarium ear rot diseases cereal crops significant global problems causing yield grain quality losses accumulation harmful mycotoxins safety limits set european commission several fusarium produced mycotoxins mitigating risk breaching limits great importance crop producers part integrated approach disease management review examines current knowledge regarding role arthropods disease epidemiology field diseased host plants likely interact arthropods may substantially impact disease influencing spread condition shared host example disease progress fusarium graminearum doubled wheat plants aphid infested arthropods implicated disease epidemiology several cases evidence ranges observed correlations arthropod infestation increased disease severity mycotoxin accumulation experimental evidence arthropod infestation causing heightened pathogen prevalence hosts fusarium pathogens differ spore production impact host volatile chemistry influences suitability arthropod dispersal herbivores may allow secondary fungal infection wounding plant may alter host susceptibility inducing changes plant defence pathways post harvest storage arthropods may also interact fusarium pathogens instances fungivory altered behaviour arthropods towards volatile chemicals infected grain host mediated indirect pathogen arthropod interactions discussed alongside comprehensive review evidence direct interactions arthropods act vectors inoculum
gathering information capable explain customers needs usually seen quite straightforward part traditional construction process customer able tell relevant needs first stage building could designed built according gained information process lacking service abilities customer wants modify given information due change circumstances albeit change easily caused due turbulent economic situations long spans real estate development projects hence customer perspective regarding construction management process accommodated better paper case studies four premises improvement projects reported upon process altered include apply concepts continuous improvement creation process documentation covered impacts case project usability premises indoor climate conditions carbon dioxide temperature metering time lapse cameras line user feedback system documentation consists minutes meetings financial reporting time tables processes results projects analysed based key findings suggestions put forth upon improve process better serve customer interests quality improvement future authors published elsevier
knowledge epidemiologic trends meniscal injuries young active populations limited better awareness injury patterns first step lowering injury rates hypothesis meniscal injuries high school athletes would vary gender sport type exposure academic years large nationally disperse sample high schools reported athlete exposure injury data sports certified athletic trainers complete internet based data collection tool one thousand eighty two meniscal injuries reported athlete exposures overall injury rate per athlete exposures overall rate injury higher competition practice sports showed significantly higher injury rates competition compared practice injuries occurred boys yet among gender comparable sports soccer basketball track field lacrosse baseball softball injury rates higher girls boys respectively contact injury represented common mechanism surgery performed majority injuries athletes associated intra articular knee pathology meniscal injury patterns among high school athletes vary gender sport type exposure study clinically relevant recognition distinct differences injury patterns help drive evidence based targeted injury prevention strategies efforts iii
objectives determine whether bundled payments feasible orthopaedic fracture setting potential economic implications reimbursement structure design prospective setting multicenter patients participants total operatively treated patients fracture patients total joint arthroplasty tja identified using new york state statewide planning research cooperative system database interventions severity illness soi hospital charges usd length stay los days discharge disposition homebound collected main outcome measurements patients subdivided groups minor severe soi differences hospital charges los discharge disposition analyzed differences charges los discharges analyzed based minor severe soi results difference hospital charge patients minor severe soi undergoing elective tja ranged contrast patients undergoing fracture surgery exhibited differences ranging minor severe soi levels similar differences observed regarding mean hospital los homebound discharge disposition patients fracture demonstrating greater sensitivity increasing soi conclusions although bundled payments may viable option patients undergoing elective tja payment model requires particular attention applied fracture care
investigated navigation related age effects learning proactive interference semantic clustering recognition hits false recognitions naturalistic situation using virtual apartment based task also examined neuropsychological correlates executive functioning episodic memory navigation related age effects memory younger older adults either actively navigated passively followed computer guided tour apartment results indicated active navigation increased recognition hits compared passive navigation influence memory measures learning proactive interference semantic clustering similar extent either age group furthermore active navigation helped reduce false recognitions younger adults increased made older adults differential effect active navigation younger older adults accounted score like subject performed task effects effects navigation manipulation well accounted item specific relational processing distinction also consistent source monitoring deficit older adults
biosensors rapid environmental pollution detection designed biomodule based bacterial bioluminescent system usually method returns total value toxicity allow distinguish pollutants types herein demonstrate classification pollutants kinetic analysis utilizing artificial neural networks multilayer perceptron architecture kinetics light emission nad fmn oxidoreductase luciferase bioluminescent reaction measured clean water presence three environment pollutants benzoquinone copper sulfate dihydroxybenzene separately various concentrations efficiency using multilayer perceptron sigmoid activation function processing kinetics light emission estimated shown multilayer perceptrons allowing distinguish pollutant class concentration sufficient training architecture consisted inputs neurons hidden layers output neurons found optimum sense learning time classification three pollutants usage simplest activation function sigmoid backpropagation method multilayer perceptron teaching providing results useful smart signal processing computational modules biosensors elsevier rights reserved
due technical bottlenecks errors caused artificial operation problem incomplete data always exists big data research traditional data imputation algorithms incur high complexity accuracy reach desired level time analysis computation involved mass data makes limitation traditional algorithms computing platform noticeable paper propose data imputation method based apriori algorithm implement corresponding algorithm distributed computing system built spark experimental results show proposed algorithm outperforms traditional data imputation algorithm terms efficiency accuracy
potential use rainwater harvesting conjunction miscellaneous water supplies rooftop garden rainwater harvesting facility temperature reduction evaluated study hong kong various water applications toilet flushing areal climate controls systematically considered depending availability seawater toilet flushing using geographic information system gis water supplies district area precipitation per demand ratio apdr calculated quantify rainwater utilization potential administrative district hong kong districts freshwater toilet flushing prove higher potential rainwater harvest utilization compared areas seawater toilet flushing furthermore effectiveness using rainwater harvesting miscellaneous water supplies hong kong tokyo analyzed compared revives serious consideration diurnal seasonal patterns rainfall applying technology terms cooling effect implementation rooftop rainwater harvesting garden evaluated using envi met model results show temperature drop degrees observed due rainwater layer rain garden study provides valuable insight applicability rainwater harvesting sustainable water management practice highly urbanized city elsevier ltd rights reserved
physics simulation active research topic games without realistic physics even beautiful game feels static lifeless although cloth simulation new computer graphics high level details cloth video games rare mostly coarse due complex nonlinear physical properties cloth requires substantial computing power necessary simulate real time paper presents robust scalable real time cloth simulation framework exploring variety modern simulation techniques produce realistic cloth simulation games framework integrates opencl gpgpu library leverage parallelism final result api games development enriched interactive environments
power plant simulation system fluid network widely present model accuracy largely determines merits simulation system concept signal flow graph introduced mechanism modeling process describe fluid network various structures fluid network classified node branch algorithm relationship node pressure according identify unknown parameters model using pso influence parameters pso process optimization could studied range unknown parameters could determined optimization could accelerated achieve optimal results
perfect multiband metamaterial absorber based triple hexagonal shaped resonators proposed paper absorber possesses nearly wide angle perfect absorption incidence wave represents polarization independence absorption occurred three different frequencies absorptivity high ghz ghz ghz respectively proposed metamaterial absorber wide applications stealth technology thermal detector imaging moreover good agreement simulation measurement results observed
large scale field programmable analog array ics made analog analog digital signal processing techniques accessible much wider community given opportunity present framework considering analog signal processing asp techniques low power systems core paper definition analog abstraction methodology creation library high level analog computation blocks abstracting analog design ensure users similar experience would expect digital design thus empowering system level engineers take advantage asp concepts result paper pull analog computation toward system level development comparable trend digital system design last years
account increasingly strict needs engine efficiency emission control fuel air ratio far control arrangements internal combustion engines ices still incessantly developed effects time delay limit far controller gains degrade system performance paper addresses control system design far ices suffer unknown time delay induced due several reasons unknown evaporation time unknown fuel quantity injected combustion process imperfection model used describe far relation surrounding factors affect combustion process new theorem proposed context depending routh hurwitz technique manipulating poles cancellation control method achieve required control action mathematical proof introduced proposed theorem numerical simulation performed illustrate validity control scheme
observations suspension bridge show thermal expansion contraction cycles follow simple linear relationships single temperature value time lag temperature distribution significant factors investigation explores effects simulating transient thermal quasistatic response tamar bridge separate finite element models bridge suspension cables thermal loads determined calculated solar radiation intensities temperature data bridge monitoring system cloud cover plays important role levels solar radiation cloud coverage estimated indirectly using monitored temperature differences top bottom suspended structure results demonstrate peak temperatures suspended structure cables occur different times lag caused differing material properties surfaces ability absorb lose heat transient phenomena manifest structural responses tower sway doi asce american society civil engineers
large nonlinear unconstrained binary optimization problems arise broad array applications several exact heuristic techniques proved quite successful solving many problems objective function quadratic polynomial however similarly efficient methods available higher degree case since high degree objectives becoming increasingly important certain application areas computer vision various techniques recently developed reduce general case quadratic one cost increasing number variables introducing additional auxiliary variables paper initiate systematic study quadratization approaches provide tight lower upper bounds number auxiliary variables needed worst case general objective functions bounded degree functions restricted class quadratizations upper bounds constructive thus yielding new quadratization procedures finally completely characterize minimal quadratizations negative monomials
generally electrical circuits fabricated pcb printed circuit board mounted casing product requires lots parts labor assembly recently molding technology increasingly applied embed simple circuits plastic casing technology called mid molded interconnected device using technology pcb fabrication replaced molding lot corresponding assembly process pcb eliminated circuit simple enough molding furthermore improvement conductive materials printing technologies electric circuit simple circuits printed directly part casing reduces complexity product design production cost also therefore paper introduces new mid fabrication process using direct printing technology applied automotive part cruise control switch methodology design shown
oily wastewater needs effectively treated minimize hazardousness environment flotation excellent pre treatment technology low content oily wastewater small oil droplets separation process flotation complicated involves theories thermodynamics kinetics hydrodynamics despite numerous theoretical numerical simulation experimental investigations mechanism flotation remains far fully understood paper uses cfd pbm numerical simulation method research dynamic separation characteristics oil droplets including oil droplet diameter distribution sauter mean diameter oil water separation efficiency different circulating flow rates corresponding different turbulent kinetic energy micro macro scale results showed oil droplet diameter distribution consistently changing separation process coalescence breakup oil droplets improvement turbulent kinetic energies turbulence intensity effectively promote collision efficiency oil droplets accelerate oil water separation process turbulent kinetic energies turbulence intensity strong strong shear stress fluid promote breakage oil droplets result decrease oil water separation efficiency circulating flow rate collision coalescence efficiency oil droplets strong enough shear stress fluid relatively weaker oil water separation efficiency reached highest numerical simulation results verified experimental results shows simulation results agreement experimental results micro scale macro scale indicates numerical simulation method cfd pbm stable reliable elsevier rights reserved
objective introduction close functional neuroanatomical relationship olfactory ability emotional processing present study seeks explore association olfactory ability social cognition especially facial emotion perception euthymic bipolar patients methods thirty nine euthymic outpatients meeting dsm criteria bipolar disorder healthy volunteers matched socio demographic criteria recruited groups assessed one time point university pennsylvania smell identification test upsit emotion recognition test faux pas recognition test well measures general cognition functioning results bipolar patients showed significant impairment olfactory identification upsit social cognition measures compared healthy controls analyses revealed significant relationships olfactory identification facial emotion recognition theory mind general cognition trend level relationship functioning controlling age cigarettes smoked relationships remained significant olfactory function facial emotion recognition conclusion deficit olfactory identification euthymic patients bipolar disorder correlated deficit verbal non verbal measures social cognition
social isolation major source stress lead activation hypothalamic pituitary adrenal hpa axis presence close social partner reduce magnitude hpa axis response stressor phenomenon known social buffering oxytocin oxt system identified one candidate mediating social buffering due role facilitation social bonding expression prosocial behavior goal present study determine whether oxt system contributes social buffering hpa axis activity response stressor exposure marmoset monkeys callithrix jacchus male female marmosets experienced standardized psychogenic stressor without long term mate oxt treatments pro oxt leu oxt oxt antagonist saline assessed hpa axis activity measuring urinary cortisol across stressor found blocking augmenting oxt system altered patterns cortisol proximity behavior response stressor demonstrated presence mate stressor significantly attenuated hpa axis activity female male marmosets male female marmosets treated oxt antagonist significantly higher hpa axis activity across stressor treated saline suggesting oxt system may reduce stressor induced rise cortisol levels male female marmosets treated oxt antagonist spent significantly less time close proximity mate first min stressor treated saline suggesting oxt system may important expression partner seeking behavior stressor thus oxt system social context differentially influenced hpa axis responded stressor male female marmosets may modulate hpa axis activity promoting expression proximity behavior close social partner elsevier ltd rights reserved
background treatment nail psoriasis remains challenging often disappointing situation objective compare efficacy adverse reactions tolerability treatment nail psoriasis pdl yag association betametasona calcipotriol gel methods open prospective intrapatient left right study designed right hand patient received treatment pdl left hand yag betamethasone calcipotriol gel applied day first week laser session total four sessions administered results clinical efficacy evaluated according napsi score patients showed improvement nail bed nail matrix psoriasis global napsi mean declined neither statistical difference reduction nail bed matrix napsi treatment pdl yag administration yag painful serious adverse effects documented limitations random assignment small number patients conclusions pdl yag proven effective treatment nail psoriasis serious adverse effect statistically significant difference found two treatments published elsevier espana behalf aedv
gestation period agoutis range days knowledge regarding morphological characteristics embryos fetuses important base studies reproduction biotechnology vitro fertilization embryo transfer helps determining congenital anomalies development phase thus given importance lack information agouti embryology objective study characterize external morphology define biometry embryos fetuses different days development nine females submitted daily colpocytology identify estrus confirm mating identify day zero gestation mating confirmed weighed underwent abdominal ultrasonography surgery conducted females gestational ages days sixteen embryos fetuses weighed measured agouti embryos days mating shaped primitive structures crown rump weighed days mating crown rump weighed days mating crown rump weighed days mating crown rump weighed days mating crown rump weighed days mating crown rump weighed days mating skin dark crown rump weighed days mating crown rump fetuses weighed based morphological data assessed embryo fetus age could assessed size average weight agouti embryos established elsevier rights reserved
new version extended irreversible thermodynamics eit satisfying hamiltonian structure proposed pedagogical purpose simple problem linear heat conduction rigid body investigated illustrate general framework contrast earlier versions eit wherein heat flux upgraded status state variables select conjugate dual higher order fluxes new independent variables time evolution equations formed reversible irreversible terms take arbitrary form restrictions placed reversible terms imposing hamiltonian structure irreversible contribution subject requirement satisfy second law thermodynamics explicit expressions temperature heat flux waves also derived
concrete widely used building material thereby contributes growing cement demand constructions climate changes due global warming becoming important issue since cement industry responsible total amount carbon dioxide emissions world wide therefore researchers seeking sustainable alternatives solve problem large amount fly ash create new opportunities use waste substitute ordinary portland cement concrete production binders could also produced reaction alkaline liquid materials containing reactive alumina silicate waste materials slag fly ash binders called geopolymers could new alternative green building material concrete production present paper going explore extended state art specifications use fly ash based geopolymer concrete environmental impact mixture proportions manufacturing process last least long term properties fly ash based geopolymer concrete
children begin show preferences specific playmates early first years life children autism spectrum disorder difficulty making friends even elementary middle school however little known earlier friendships children autism preschool friendships study examined friendships preschool children autism explored joint attention contributes friendships mainstream settings secondary aim determine extent teachers used strategies facilitate friendship development participants mainstreamed preschool children ages years autism spectrum disorder school observations conducted individually capture participants interactions peers adults free play results indicated participants friendships school children friends likely children without friends jointly engaged peers free play used higher joint attention skills teachers used friendship facilitating strategies often used behavioral management strategies within classrooms future studies may want examine effects early interventions teacher training development friendships preschool children autism spectrum disorder within school setting
development software intensive technical systems involves several engineering disciplines like mechanical electrical control particularly software engineering model based systems engineering mbse coordinates disciplines throughout development means discipline spanning processes system model system model provides common understanding system development serves starting point discipline specific development integral part mbse requirements engineering system level however requirements need refined discipline specific development start example specific requirements embedded software existing mbse approaches lack support refinement step conceived previous work systematic transition mbse model based software requirements engineering automated steps transition possible order avoid error prone time consuming manual tasks paper extend approach support subsequent process iterations provide algorithm automated steps illustrate approach perform case study example automotive embedded system copyright john wiley sons ltd
wood renewable abundant bio energy environment friendly resource woody biomass moisture content key parameter controlling biofuel product qualities properties paper interested predicting data input impedance half wave dipole antenna buried wood pile varies according permittivity wood hence measurement reflection coefficient gives information input impedance depends directly wood relationship reflection coefficient measurements studied based upon relationship predictive models use machine learning techniques feature selection methods proposed numerical experiments using real world data show relevance proposed approach requires limited computational power therefore real time implementation industrial processes feasible elsevier rights reserved
finding proper design patterns always important research topic software engineering community one main responsibilities software developers determine design pattern fits best solve particular problem design patterns support effort exploring use artificial intelligence better management software development maintenance process providing faster less costly smarter time decisions pena mora vadhavkar permanent interest finding new design patterns especially last two decades many new design patterns apply various areas computer science software security software parallelism large scale software evolving artificial intelligence best knowledge obligation link history reminder design patterns new applied software development many areas computer science including artificial intelligence
temporal networks data structures representing reasoning temporal constraints activities many kinds temporal networks defined literature differing expressiveness simplest kinds networks polynomial algorithms determining temporal consistency different levels controllability corresponding algorithms expressive networks include observation nodes disjunctive constraints far unavailable paper introduces new approach determine dynamic controllability expressive class temporal networks accommodates observation nodes disjunctive constraints approach based encoding dynamic controllability problem reachability game timed game automata tgas first sound complete approach determining dynamic controllability networks encoding also highlights theoretical relationships various kinds temporal networks tgas new algorithms immediate applications design analysis workflow models developed automate business processes including workflows health care domain
need explore circuit application new emerging technologies rapid commercialization cmos technology approaching limits carbon nanotube field effect transistor cnfet promising candidate future electronic devices low power low voltage digital analog circuit application paper presented low power low voltage cnfet operational amplifier opamp based analog arithmetic computing circuit inverting amplifier noninverting amplifier summer substractor differentiator integrator low power analog signal processing application proposed computing circuits operation studied using hspice software circuit simulation input supply voltage simulation results show proposed computing circuits well suited low power low voltage analog signal processing application lower power consumption high speed operation authors published elsevier ltd
regulation organ growth critical embryogenesis cellular level mechanisms controlling size individual embryonic organs include cell proliferation differentiation migration attrition cell death mechanisms play role cardiac morphogenesis experimental studies shown major determinant cardiac size prenatal development myocyte proliferation proliferative capacity becomes severely restricted birth number cell divisions occur embryogenesis limits growth potential postnatal heart summarize current knowledge concerning regional control myocyte proliferation related cardiac morphogenesis dysmorphogenesis significant spatial temporal differences rates cell division peaking preseptation period gradually decreasing toward birth analysis regional rates proliferation helps explain mechanics ventricular septation chamber morphogenesis development cardiac conduction system proliferation rates influenced hemodynamic loading transduced autocrine paracrine signaling means growth factors understanding biological response developing heart factors physical forces progress engineering artificial myocardial tissues heart repair designing optimal treatment strategies congenital heart disease developmental dynamics wiley liss inc
hematological abnormalities common course systemic lupus erythematosus sle myelofibrosis bone marrow disorder excessive fibrous tissue formation bone marrow various benign malignant disorders cause associated diffuse increase bone marrow reticular tissue diseases infections neoplasms autoimmune diseases may also induce bone marrow fibrosis secondary myelofibrosis cytopenia autoimmune myelofibrosis aimf sle rare condition present case aimf associated sle aim emphasize cause cytopenia sle
consider natural spline interpolation based reduced data called exponential parameterization depending parameter lambda element particular latter studied context trajectory approximation arbitrary euclidean space term reduced data refers ordered collection interpolation points without provision corresponding knots numerical verification intrinsic asymptotics alpha lambda gamma approximation natural spline gamma conducted regular sufficiently smooth curve gamma sampled less uniformly select paper substitutes missing knots according exponential parameterization outcomes numerical tests manifest sharp linear convergence orders alpha lambda lambda element addition latter results unexpected left hand side dis continuity lambda since shown sharp quadratic order alpha prevails remarkably case alpha derived reduced data coincides well known asymptotics established natural spline fit non reduced data determined sequence interpolation points supplemented corresponding knots see
musculoskeletal disorders msds considered major public health problems purpose study determine prevalence msds azar cohort population northwest iran azar cohort study state level national cohort project persian began adults years old khamene city east azarbaijan province recruited pilot phase azar cohort purpose current study total subjects age range completed community oriented program control rheumatic disease copcord questionnaire supplementary included subjects msds introduced rheumatologist referred assessment subjects msds within past days frequent complaint pain common sites complaints knee lumbar spine shoulder respectively osteoarthritis common rheumatic disease knee common region affected followed low back pain osteoarthritis knee osteoarthritis present females males respectively furthermore low back pain present males females peri arthritis prevalent males whilst fibromyalgia psychologic pain heel spur prevalent among females respectively rheumatoid arthritis observed males females respectively prevalence msds high area therefore calls action heath officials professionals plan appropriate programs prevention management msds society
treatment management food processing waste major challenge food industry potato processing industry generates tremendous amount peel consider zero valued waste pomace generated juice extraction sweet lime pulp considered waste properly utilized whereas waste could utilized development biodegradable packaging film overcome environmental issues composite films prepared varying proportion potato peel powder sweet lime pomace slp ratio ultrasound treatment min ultrasound treatment min ultrasound applied min film forming solutions break biopolymer particles small enough form film films analyzed barrier mechanical properties observed increasing ultrasound treatment times gives better result film properties less content also gives better film properties observations film prepared slp showed better characteristics among films water vapor permeability moisture absorption water solubility breakage strength elongation capacity film reported respectively however thermal decomposition film took place film forming solution selected film added clove essential oil antimicrobial agent wrapped bread stored days film successful lowering weight loss reducing hardness inhibition surface microbial load bread sample elsevier rights reserved
introduction episodic ataxias eas rare dominantly inherited neurological disorders characterized recurrent episodes ataxia lasting minutes hours common subtype type caused pathogenic variants calcium voltage gated channel subunit alpha gene cacnaa chromosome subjects methods examined slovak three generation family genomic dna family members extracted peripheral blood amplified polymerase chain reaction cacnaa variants screened sanger sequencing results identified four family members recurrent episodes ataxia complex differential diagnosis performed genetic analysis direct sequencing revealed novel heterozygous variant cacnaa glugly located pore loop domain calcium channel alpha subunit conclusion identified novel missense variant voltage dependent type calcium channel alpha subunit slovak three generation family recurrent episodes ataxia heterozygous missense variant resulted changing highly conserved glutamic acid within pore loop domain
common method used minimizing occurrence diabetes complications frequent glucose testing adjust insulin dose however using blood glucose meters presents risk infection great importance develop non invasive detection techniques realize high accuracy low cost continuous glucose monitoring developed non invasive detection system using mixed signal processor msp microcontroller method based combination conservationof energy method sensor integration module collects physiological parameters blood oxygen saturation spo blood flow velocity heart rate new methods detect basal metabolic rate bmr proposed combine human body heat balance characteristic signals photoplethysmography well dual elastic chambers theory four hundred clinical trials real time non invasive monitoring suitable experiment conditions performed different individuals including diabetic patients senior citizens healthy adults multisensory information fusion model applied process samples algorithm defined dcbpn algorithm applied model combines decision tree back propagation neural network classifies physiological environmental parameters three categories establishes corresponding prediction model three categories dcbpn algorithm provides accuracy predicting new samples thus system demonstrates great potential reliably detect values non invasive setting
use personal care products widespread united states tends greater among african americans whites special concern possible hazard absorption chemicals estrogenic activity anti aea products exposure may adverse health effects especially occurs developmental windows prepubertally estrogen levels low assessed ethanol extracts eight commonly used hair skin products popular among african americans aea using cell proliferation assay estrogen sensitive mcf cell line derived human breast cancer four eight personal care products tested oil hair lotion extra dry skin lotion intensive skin lotion petroleum jelly demonstrated detectable whereas three placenta hair conditioner tea tree hair conditioner cocoa butter skin cream exhibited aea data indicate hair skin care products aea suggest laboratory studies warranted investigate vivo activity products chronic exposure conditions well epidemiologic studies investigate potential adverse health effects might associated use products
paper considers parallel hybrid electric truck tractive force delivered wheels provided conventional internal combustion engine ice motor generator hybrid truck equipped clutch system capable decoupling ice themg drivetrain improve fuel reduction performance compared hybrid truck without separate clutch considered hybrid truck energy management strategy utilizes battery reduce fuel consumption associated emissions battery life limited vehicle owner suffer extra costs battery replacement henceforth necessary guarantee sufficient battery life paper develops quasi static battery cycle life model formulates model based integrated energy management iem strategy iemstrategy optimizes power split ice operation clutch system minimize hybrid truck fuel consumption guaranteeing requested battery life problem fuel minimization battery life guarantee analytically solved using optimal control theory mathematical physical arguments used explain compromise fuel reduction battery life preservation simulation results demonstrate iem strategy guarantee requested battery life different driving cycles allowing appropriate hybrid powertrain operations fuel minimization moreover results also show fuel reduction improvement decoupling drivetrain using clutch system
sub harmonic mixers core element terahertz room temperature high spectral resolution heterodyne receivers planetary science remote sensing terahertz sub harmonic mixer ghz using discrete schottky diode presented measured performance agreement results linear nonlinear simulations methodology shows practicability discrete planar gaas schottky diode based terahertz core circuit design
information security recent years become important area always necessity exchanging information secretly sender receiver cryptography reveals deep roots history providing way transmit sensitive information across networks intended recipient read several methods encryption decryption developed improve security information transmitted last years evidence encryption evidently present ancient vedic indian period example sri ram shalakha placement couplets paper contemporary approach developed product cipher harness dominant features vedic encryption style well incorporate classic behavior feature modern cryptographic algorithms
reducing large scale deforestation commodity frontiers remains key challenge climate change mitigation conservation biodiversity public private anti deforestation policies shown effectively reduce forest loss conditions policies get adopted rarely examined propose set conditions expect associated adoption effective anti deforestation policies commodity frontiers examine whether conditions influenced policy adoption south america major soy cattle frontiers brazilian amazon cerrado chaco chiquitano paraguay atlantic forest collating empirical data diverse sources including literature review extensive expert interviews analysis primary secondary data show cerrado chaco chiquitano differ brazilian amazon multiple ways might inhibited adoptions effective anti deforestation instruments conditions include higher importance agricultural sector within respective countries lower carbon stocks species richness higher prevalence private land tenure higher baseline compliance forest reserve regulations private lands also observe adoption effective private anti deforestation instrument commodity moratoria may respond similar conditions influencing adoption public instruments incentivizing public private actors adopt effective anti deforestation policies cerrado chaco chiquitano likely challenging brazilian amazon elsevier ltd rights reserved
ergonomic principles integration manufacturing engineering processes design development becoming common practice companies regard muscle skeletal injuries important impact workplaces evaluation measurement risk factors important step towards workplace excellency work described evaluation methods commonly used showed application rula rapid upper limb assessment reba rapid entire body assessment methods metal sector company help virtual simulation tool arc integrated methods via external programming entire production process evaluated improvements suggested order eliminate ergonomic risks improve production system objective paper show advantages using tools well implement adequate observation method field
purpose review conscientious objection reproductive healthcare refusal perform abortion assisted reproductive technologies prenatal diagnosis contraception including emergency contraception sterilization etc become widespread global phenomenon constitutes barrier services many women adolescents particularly vulnerable group providers object specific aspects reproductive healthcare status minors recent findings recent peer reviewed publications concerning conscientious objection address provider attitudes abortion emergency contraception ethical arguments conscientious objection calls clarification current laws regarding conscientious objection legal case commentaries descriptions country specific impact policies russia italy summary conscientious objection understudied complicated appears constitute barrier care especially certain subgroups although degree conscientious objection compromised sexual reproductive healthcare adolescents unknown physicians well positioned support individual conscience honoring obligations patients medical evidence
composite nanofibers nio gamma alo fabricated sol gel processing electrospinning followed calcination precursor composite fibers nickel acetate aluminum acetate polyvinylpyrrolidone calcination high temperatures allows preservation nion alo fibrous form fineness diameter composite fibers calcined degrees exhibited nickel oxide gamma alumina phases higher calcination temperature found favor crystalline development eds analysis confirmed ratio precursor formulation prepared electrospinning finally photocatalytic activity nio gamma alo nanofibers comparison tio nanoparticles investigated evaluating photodegradation hazardous dye rhodamine found fabricated nio gamma alo composite nanofibers possessed photocatalytic efficiency nearly photocatalytic activity tio nanoparticles recycled easily work offers direct insight comparison photocatalysis nio gamma alo nanofibers tio nanoparticles suggests great potential using developed nanofibrous nio gamma alo practical photocatalysis applications various air water pollution controls elsevier ltd techna group rights reserved
objectives physiotherapeutic practice special attention given reciprocal anatomical physiological biomechanical relationship pelvis structures connected however scientific literature shows mainly theoretical information mutual connections lack information relations practical aspect coupled paucity scientific papers impact posture changes pelvic floor led authors conduct study primary aim study compare resting functional bioelectrical activities pelvic floor muscles pfms depending three different positions lower limbs positions supine position materials methods prospective observational study evaluating resting functional activities pfm depending position lower limbs study carried department clinic urology university hospital wroclaw poland target group women menopausal period bioelectrical activity pfm recorded using surface electromyographic instrument supine position results values obtained positions compared using one way analysis variance results position average resting surface electromyography semg activity pfm position result position resting semg activity results functional bioelectrical activity pfm follows position position position conclusion results showed supine position pfm achieved lowest resting activity highest functional activity therefore supine position recommended diagnosis therapy weakened pfm
ineffective communication poor application communication skills construction project management lead project outcomes meet project objectives lack proper communication skills model project management may contribute ineffective project communication article reports results study done identify important project management communication skills applications communication effective project managers possess literature review project management communication project communication skills applications project communication project management leadership communication done develop quantitative questionnaire testing importance project management communication skills applications communication perceived total construction related professionals employed construction project management architecture construction management engineering quantity surveying based findings communication skills applications communication expected project managers grouped core decision making problem solving listening verbal competency motivation persuasion meetings writing competency presentation team building development conflict management important skills negotiation trust explaining questioning reinforcement reflecting public communication humour laughter self disclosure together managerial leadership communication form main basis proposed model proposed model may assist construction project managers developing communication abilities improved communication improve management leadership abilities ensuring successful execution projects south african construction industry
motion projectile easily observable phenomenon knowledge behavior projectiles used extensively warfare since many centuries cannons present day gps guided missiles rely principles projectile motion apart missiles flying golf ball interesting subject study projectiles actual flight path simulated digital computer computer graphics natural setting golf ball motion dependent various environmental factors paper apart initial velocity angle launch resistance due air cross wind effects also considered end projectile flight landing simulated using bouncing ball physics theory object motion utilized adapted simulation position configuration object environmental conditions taken variables modelling flight
compute intensive applications gradually changed focus massively parallel supercomputers capacity resource obtained demand particularly true large scale adoption cloud computing mapreduce industry difficult traditional high performance computing hpc usage scientific engineering computing exploit type resources however strong trend increasing parallelism rather faster processors growing number applications target parallelism already algorithm level loosely coupled approaches based sampling ensembles trivially formulated mapreduce highly amenable throughput computing many general powerful frameworks particular sampling based algorithms scientific computing clear advantages platform scheduler highly aware underlying physical problem present challenges addressed combinations dataflow programming peer peer techniques peer peer networks copernicus platform allows automation sampling focused workflows task generation dependency tracking least distributing diverse set compute resources ranging supercomputers clouds distributed computing across firewalls fragile networks workflows defined modules using existing programs makes reusable without programming requirements system achieves resiliency handling node failures transparently minimal loss computing time due checkpointing single server manage hundreds thousands cores computational chemistry applications authors published elsevier open access article license
high rates sustained virologic response post treatment week svr achieved six phase trials ombitasvir obv nsa inhibitor paritaprevir protease inhibitor dosed ritonavir ptv dasabuvir dsv nsb rna polymerase inhibitor regimen without ribavirin rbv adults chronic genotype hepatitis virus hcv infection assessed whether time first hcv rna value lower limit quantification patients without cirrhosis associated achievement svr data analysed infected patients enrolled six phase studies rbv patients experienced non virologic failure excluded analysis hcv rna determined using roche cobas taqman pcr assay lower limit quantification lloq svr analysed week first hcv rna suppression defined hcv rna lloq analysis included total patients cumulative proportions subjects initial hcv rna suppression lloq weeks respectively svr achieved patients initial suppression weeks respectively trend test across six phase trials rbv patients achieved viral suppression week time viral suppression associated subsequent achievement svr suggesting treatment virologic monitoring may necessary regimen
aims test safety new buprenorphine oral lyophilisate wafer bup lyo versus standard sub lingual buprenorphine bup design randomised openlabel study opioid dependent subjects subsequent partial cross settings specialised clinical trials facility addictions treatment facility participants opioid dependent subjects commencing buprenorphine maintenance personalised dose titration including patients cousing alcohol cocaine benzodiazepines thresholds measurements respiratory function respiratory rate pulse oximetry medication hold dose adequacy opiate withdrawal signs symptoms tablet disintegration times treatment retention pharmacokinetics plasma buprenorphine norbuprenorphine findings oral lyophilised buprenorphine bup lyo completely dissolved within min bup dose titration resulted similar maintenance dosing significant group differences opiate withdrawal phenomena craving adequacy hold respiratory function serious adverse events aes severe aes although aes treatment emergent aes bup lyo mostly mild found greater bioavailability buprenorphine bup lyo norbuprenorphine conclusions orally disintegrating buprenorphine oral lyophilisate wafer disintegrated rapidly increased respiratory depression found clinically difference medications observed found substantially increased bioavailability buprenorphine buprenorphine buplyo relative bup supervised dosing contexts rapidly disintegrating formulations may enable wider buprenorphine prescribing karger basel
introduction end stage renal disease esrd reasons several changes function thyroid gland lower levels thyroid hormones altered hormone metabolism increased iodine storage aim study evaluate prevalence nodular goiter hypothyroidism hemodialysis patients compared normal population methods cross sectional study conducted among patients healthy people control group thyroid function evaluation thyroid gland evaluated physical examination ultrasonography blood level tsh tpo urinary iodine excretion checked groups data analyzed using spss value less considered significance level findings eighty six patients mean age men healthy people mean age men enrolled study goiter confirmed physical examination patients control group nodular goiter shown ultrasonography found control groups respectively patients higher frequency reduced increased tsh tpo positive control groups discussion high incidence nodular goiter hypothyroidism esrd patients shows screening thyroid dysfunction goiter using appropriate laboratory tests considered evaluations esrd patients
outside japan early history japanese woodblock printed children literature continues insufficiently understood even topic controversial insofar contemporary scholars denied existence japanese children literature prior nineteenth century importation western notions child examining young boy collection picture books sealed inside statue bodhisattva jizo around present article seeks illuminate contents principal themes boys books incipient form japanese children literature apparently written consumed children published kyoto osaka region particular article takes issue extravagant representational violence subset four illustrated warrior tales obvious links contemporaneous sekkyo joruri puppet theaters exploring salient features works historical literary contexts
central buckle often used suspension bridge improve bridges performance actual operation condition influence central buckle natural vibration characteristics bridge deck driving comfort long span suspension bridge studied using case study siduhe suspension bridge china based finite element software ansys independently complied program influence central buckle structure force applied characteristics long span suspension bridge explored results show huge increases natural frequencies result presence central buckles increases bending torsional rigidities central buckle basically makes stiffening girders cables within triangular area covered relatively approximate rigid area hence central buckle reduce torsional displacement main girder however increases bending torsional rigidities little influence impact factor obtained using vehicle bridge coupled vibration analysis means central buckle little effect comfort indices addition found central buckle enhance bridge deck driving stability due decrease torsional displacements main girder
objectives two genome wide association studies gwas identified receptor receptor beta ilrb susceptibility genetic region turkish japanese population behcet disease investigated association region northern chinese han population methods total patients healthy controls genotyped single nucleotide polymorphisms snps using sequenom massarray system results statistically significant associations detected two snps namely allele analysis respectively genotype analysis respectively significant differences observed genotype frequency distribution snps additive dominant recessive models haplotypes formed two snps associated permutation meta analysis also appeared support association two snps conclusion snps ilr ilrb region found associated northern chinese han population american society histocompatibility immunogenetics published elsevier inc rights reserved
disruption circadian rhythms provoked artificial lighting night inconsistent sleep wake schedules transmeridian air travel increasingly prevalent modern society desynchrony biological rhythms environmental light cycles dramatic consequences human health particular disrupting homeostatic oscillations endocrine tissues hormones tissues regulate cascading effects physiology behavior accumulating evidence suggests chronic disruption circadian organization endocrine function may lead metabolic reproductive sleep mood disorders review discusses circadian control endocrine systems consequences distorting rhythmicity systems
liberalization policies challenges integrating distributed generation resources recent flattening electricity demand due economic crisis technological change led lower returns european electricity suppliers innovative sustainable business models needed serve electricity customers reflecting operational needs system maintaining supplier financial viability paper describes novel model integrated energy services encompasses distributed generation demand response resources industrial customers reflect market opportunities regulatory drivers development similar schemes across europe elsevier ltd rights reserved
study focuses ant colony optimization aco decision making skills tactics badminton model decision making skills tactics badminton based aco put forward explained ultimate objective win competitive sports relying skills tactics according technical tactical characteristics badminton competition concluded based item group theory simulation model ant colony system formulated providing theoretical support algorithm design vividly explaining principle mechanism ant colony route search
pediatric surveillance units psus provide unique model study pediatric eating disorders eds australia britain canada surveillance programs generated valuable epidemiological clinical data early onset eating disorders eoed psus represent important collaborative tool helped shape understanding eoeds offers potential contribute decisions regarding health resource allocation public health policy paper reviews role psus unique model study pediatric eds success translating knowledge generated programs improving health children adolescents eds worldwide
study perception affect via nonverbal cues investigated children learning disabilities comparing peers typical development participants third fourth fifth graders consisting children total relational method screening used study data gathered using test perception affect via nonverbal cues tpanc developed researchers test four subtests including mimics posture gestures voice social stories examining perception nonverbal cues related six different emotions happiness sadness fear anger amazement disgust one way analysis variance used analyze data results showed performance children learning disabilities perceiving nonverbal cues affect significantly lower peers typical developments subtests significant differences found children learning disabilities typical development third fourth grades significant differences found performances boys girls learning disabilities
resource constrained project scheduling problem classic problem construction project aimed solving problem effective approach decomposition time windows proposed paper approach select one activity decomposition arid partition feasible space original problem feasible subspaces solutions generated using extended serial scheduling scheme double justification also performed process searching subspace four strategies selecting activity decomposition three strategies decomposition strategy sampling size various subspaces designed results experiments two real construction projects show strategy based degree selecting activity strategy based initial schedule decomposition obtain best results compared exiting algorithms proven decomposition based approach effective competitive elsevier rights reserved
paper aims developing innovative technique concurrent multi objective optimisation updating multi scale model long span bridges multi scale model established purpose concurrently analysing global response structure nonlinear local damages order assess structural state local damage evolution deteriorating respectively multi objective optimisation technique proposed work concurrent multi scale model updating several key issues including determination objective functions constraint conditions multi objective optimisation algorithm find optimal solution many non inferior solutions studied proposed concurrent multi objective optimisation technique applied update initial multi scale model runyang suspension bridge rysb near shanghai updated model validated data field tests conducted obtaining response global dynamic properties local levels
functional bowel disorders fbds functional gastrointestinal disorders symptoms attributable middle lower gastrointestinal tract include irritable bowel syndrome functional bloating functional constipation functional diarrhea unspecified fbd increasing evidence emerged late intestinal microbiota involved pathogenesis fbds review therapeutic benefits future perspectives currently available strategies modifying gut microbiota fbds described focusing primarily irritable bowel syndrome functional constipation
stopping denosumab years continued treatment associated bone loss year observation study patients prescribed osteoporosis treatment bone loss attenuated patients began another osteoporosis therapy treatment prevent bone loss upon stopping denosumab considered study aimed understand osteoporosis management strategies year observational follow years denosumab treatment phase study observational year patients received osteoporosis management discretion physician returned clinic bmd assessment completion osteoporosis management questionnaire incidence serious adverse events fractures collected analyses descriptive eligible patients enrolled completed observation study receive prescription osteoporosis medication doctor felt longer needed medication common reason patients took osteoporosis medications discontinued therapy observation study patients treated denosumab years bmd decreased year observation study lumbar spine total hip took osteoporosis medication observation study showed smaller decline bmd new safety concerns identified eight patients least one predisposing risk factor experienced fractures included seven patients experienced one vertebral fractures consistent denosumab mechanism action treatment cessation led reversal drug effect bmd perhaps fracture risk patients took osteoporosis therapy bone loss attenuated patients high fracture risk switching another osteoporosis therapy denosumab discontinued seems appropriate
aims study aims evaluate bothersome lower urinary tract symptoms luts risk factors associated functional abnormalities women reporting adult onset secondary nocturnal enuresis sne help understand factors associated sne methods women age attending tertiary referral centre underwent comprehensive standardized evaluation including urodynamic testing accordance international continence society recommendations records patients reporting bedwetting asleep evaluated various categories multiple logistic regression used identify statistically significant risk factors urodynamic findings associated sne results prevalence sne women undergoing urodynamic testing bothersome luts high bmi cigarette smoking antidepressant usage neurological conditions previous hysterectomy significantly associated sne women sne significantly complained overactive bladder oab symptoms slightly higher mean nocturia episodes low maximum urethral closure pressure mucp detrusor overactivity incontinence doi significantly associated sne significant association symptom stress urinary incontinence urodynamic stress incontinence detrusor overactivity conclusion women adult sne usually present oab symptoms sne associated high bmi cigarette smoking antidepressant use neurological conditions doi low mucp possible pathophysiological mechanisms sne wiley periodicals inc
generalized cumulative damage approach presented yields large family accelerated test inverse gaussian type models strength materials incorporate size effect acceleration variable previous models generalized three aspects cumulative damage model general include damage functions additive multiplicative damages strength reduction function due initial damage existing material taken general function initial damage process general stochastic process includes previously assumed special cases approach taken therefore general cumulative damage model obtained date yields large number potentially useful accelerated test models material strength estimation model parameters maximum likelihood methods discussed two examples using real tensile strength data carbon micro composites single carbon fibers presented illustrating improvement new approach previous models elsevier rights reserved
collaborative inhibition finding collaborative groups recall less information nominal groups combined output equal number individuals retrieval strategy disruption explanation collaborative inhibition argues individuals idiosyncratic retrieval strategies disrupted hearing contributions others series studies investigated role retrieval interference cognitive explanations collaborative inhibition asked collaborative nominal dyads recall lists categorised words found collaborative inhibition results retrieval strategy disruption factors collaborative dyads displayed limited exploration nominal dyads sampled fewer categories thus recalled fewer words collaborative dyads different goals nominal dyads particularly limiting errors may also reduce correct recall also found time period recall contributes collaborative inhibition collaborative dyads recall fewer words early retrieval period words later nominal dyads addition found instances collaborative advantages collaborative dyads made fewer errors demonstrated recall organisation nominal dyads
objective investigate whether human amniotic fluid stem cells hafscs grafting bladder may influence bladder functional molecular changes animal stroke model female rats divided three groups sham middle cerebral artery occlusion mcao alone mcao plus hafscs transplanting bladder wall bladder function analyzed cystometry days mcao expressions bladder nerve growth factor ngf muscarinic muscarinic receptors measured immunohistochemistry real time polymerase chain reaction compared sham operated group mcao alone rats significant increase residual volume decrease voided volume intercontraction interval however bladder dysfunctions improved following hafscs transplantation immunoreactivities ngf significantly decreased days increased day mcao following hafscs transplantation immunoreactivities ngf significantly increased day increased day mcao mrnas ngf significantly increased day ngf decreased day mcao following hafscs transplantation significant decrease mrna day increase mrna days mcao bladder dysfunction caused mcao improved hafscs transplanting bladder may related expressions bladder ngf muscarinic receptors
research details development comfort interpersonal touch cit scale designed measure individual differences interpersonal touch tendencies preferences cit construct defined degree individual comfortable intentional interpersonal touch another person scale incorporates distinction initiating touch act touching someone else receiving touch act touched someone else investigation construct includes scale development measure purification validation situate cit initiating cit receiving within approach avoidance framework demonstrate comfort initiating touch related approach tendencies assertiveness comfort receiving touch related avoidant tendencies avoiding crowded spaces previous research generally finds positive effects interpersonal touch find effects least part depend individual comfort interpersonal touch discuss theoretical managerial implications well future research opportunities using cit scale society consumer psychology published elsevier inc rights reserved
objective osteoarthritis major cause musculoskeletal pain disability worldwide investigation disease modifying treatment options become important aspect orthopedic care assess effect intra articular oral glucosamine sulfate versus placebo osteoarthritis canine model materials randomized placebo controlled double blinded study induced anterior cruciate ligament transection aclt according pond nuki model canines canines allocated treatment subgroups treatment administered weeks intra articular placebo intra articular body weight oral placebo oral contralateral nonoperated stifle knee served control weeks medial lateral femoral condyles medial lateral tibial plateau patella histologically examined anatomic changes quantified light microscopy using modified mankin score results weeks mean mankin score values significantly decreased intra articular group range compared intra articular placebo group range significantly oral group range compared oral placebo group range mean mankin score values significantly lower intra articular group compared oral group conclusion intra articular oral administered significantly reduced histological signs pond nuki model intra articular application effective compared oral administration
background positive psychological constructs associated reduced suicidal ideation interventions cultivate positive feelings potential reduce suicide risk study compares efficacy week telephone based positive psychology intervention cognition focused control intervention among patients recently hospitalized depression suicidal ideation behavior method total adults current major depressive episode reporting suicidal ideation recent suicide attempt enrolled participating patient psychiatric units prior discharge participants randomized intervention interventions participants received treatment manual performed weekly gratitude letter recalling daily events exercises completed weekly one one telephone sessions weeks group differences hopelessness primary outcome depression suicidality positive psychological constructs weeks tested using mixed effects models accounting intensity posthospitalization psychiatric treatment results compared intervention associated significantly greater improvements hopelessness weeks beta confidence interval effect size weeks similarly intervention led greater improvements depression suicidal ideation optimism gratitude weeks conclusions contrary hypothesis intervention superior improving hopelessness suicide risk factors positive psychological constructs key post discharge period among suicidal patients depression study intervention warranted populations high suicide risk
background beta glucan bdg helpful diagnostic marker many invasive fungal infections nocardiosis reported first case nocardial infection high serum level bdg case presentation year old man hospitalized fever headache appetite loss months steroid immunosuppressive therapy cryptogenic organizing pneumonia diagnosis bacterial pneumonia treatment ampicillin sulbactam initiated improvement chest radiograph fever persisted work revealed multiple brain abscesses cranial magnetic resonance imaging mri serum galactomannan bdg elevated index respectively voriconazole initiated presumed aspergillus brain abscess however fever persisted consciousness level deteriorated drainage brain abscess performed based gram stain kinyoun acid fast stain disseminated nocardiosis diagnosed voriconazole shifter trimethoprim sulfamethoxazole presence nocardia farcinica confirmed rrna gene sequence treatment course continued bdg level normalized month cranial mri showed almost complete improvement months conclusion bdg assay widely used diagnose invasive fungal infection therefore clinicians aware nocardia species may show cross reactivity bdg assay serum
present study concerned numerical analysis uncertainties response foam core sandwich structures caused uncertain microstructure core material sense integrated computational materials engineering type approach three step procedure proposed first step effective material properties core material computed purpose probabilistic homogenization procedure adopted prediction elastic constants together probability distributions well spatial correlations interrelations individual parameters second step random field model core material derived based homogenization results obtained first step random fields found reproduce stochastic features uncertain core material proper manner using random field description input monte carlo type structural analysis uncertainties stiffness strength sandwich structures computed third step capabilities proposed procedure demonstrated using example single edge clamped sandwich beam transverse loads elsevier ltd rights reserved
tube receiver pin fin arrays inserting introduced absorber tube parabolic trough receiver increase overall heat transfer performance tube receiver parabolic trough solar collector system monte carlo ray tracing method mcrt coupled finite volume method fvm adopted investigate heat transfer performance flow characteristics tube receiver parabolic trough solar collector system validate feasibility developed mcrt fvm combined method numerical results compared experimental results conducted diss test facility spain max relative error less numerical results indicated introduction absorber tube pin fin arrays inserting design absorber tube parabolic trough receiver effectively enhance heat transfer performance average nusselt number increased overall heat transfer performance factor increased tube receiver pin fin arrays inserting used elsevier ltd rights reserved
green building construction considered essential practice achieving sustainability achieve sustainable development greater attention paid environmental social economic impacts associated construction operation buildings hence importance integrated approach green building design cost effectiveness gained momentum present study focuses developing appropriate constructs benchmark green building attributes construction limited funds sustainable performance building improved study indian green building assessment tools green rating integrated habitat assessment griha indian green building council igbc eco housing newly developed rating system reviewed data envelopment analysis dea employed benchmark green building attributes buildings different climatic conditions hot dry warm humid composite climates chosen benchmarking purposes efficiency calculated using constant return scale input oriented charnes cooper rhodes ccr formulation method following attributes observed utilization bureau indian standard bis recommended waste materials building increase environmental awareness dedicated facilities service staff design universal accessibility low impact design construction management practices use low volatile organic compounds voc paints contribute green points lower cost elsevier ltd rights reserved
paper aims design mixed method evaluation study target study analyze implementation building information modeling management technology architectural engineering curriculum use mixed method evaluation process based quantitative qualitative approaches measure level motivation satisfaction performance students building information modeling management bim technology obtaining proper feedback optimize implementation bim architectural engineering construction management aec curriculum
address entanglement dynamics three qubit system interacting classical fluctuating environment described either gaussian non gaussian noise three different configurations namely common independent mixed environments specifically focus ornstein uhlenbeck noise random telegraph noise rtn qubits prepared state composed greenberger hornezeilinger ghz state help tripartite negativity show entanglement evolution affected type system environment coupling also kind memory properties considered noise also compared dynamics induced two kinds noise find even noises lorentzian spectrum effects noise simple way deduced rtn vice versa addition show entanglement indefinitely preserved qubits coupled environmental noise common environment finally presence absence peculiar phenomena entanglement revivals entanglement sudden death esd observed
digimathart interdisciplinary method teaching learning uses computer graphics programming order make mathematics concepts easier understand combining arts programming mathematics helps creating complex connectomes brain highways understanding idea digimathart method describe concepts mathematics means logic games graphics kids trained dynamically according speed processing information necessary according age evaluated point evaluation method teaching learning goes means national standardized tests pupils enrolled public private systems education trained digimathart method perform high possible tested home unschoolers manifest better ability integrate comprehend math concepts math activities involve critical thinking complex concepts
botnet become popular technique deploying internet crimes command botnet evolved major way attackers launch distributed denial service attacks network servers modelized analysis methods need studied botnet attacks implements defense prediction paper propose novel game theory based model describe scenario botmaster launching distributed denial service attacks using botnet defender equipped firewall defending model consider following firstly botmaster defender rational irrational secondly interaction botmaster defender modeled dynamic game thirdly supporting self learning databases detail analysis eight sub scenarios assumptions give easy use algorithm adjustment offensive defensive strategy use opnet validate model effectiveness experiment result shows strategy improve firewall abilities lower false alarm rate improve botmaster lower exposure rate botnet avoid detection furthermore model helpful evaluate defense ability defender towards current botmaster attacks analyzing attack log sandbox copyright john wiley sons ltd
regular hybrid flow shop scheduling problem stages identical parallel machines makespan minimization investigated served natural starting point hybrid flow shop scheduling problems properties scheduling problem discussed lead theoretical foundation instruction algorithm design based active scheduling technique reversibility property genetic algorithm direction selection combined extended giffler thompson algorithm developed experimental results benchmark problems comparisons two algorithms indicate effectiveness proposed algorithm
immunoregulatory sex hormones including estrogen estriol may prevent relapses multiple sclerosis pregnancy previous studies demonstrated regulatory cells crucial estrogen mediated protection experimental autoimmune encephalomyelitis eae herein demonstrate estrogen dependent induction alternatively activated macrophages microglia results increased frequency regulatory cells spinal cord estrogen treated mice eae demonstrate cultured polarized microglia promote induction regulatory cells study suggests estrogen neuroprotection induces regulatory feedback loop macrophages microglia regulatory cells elsevier rights reserved
background increasing evidence suggests low affinity receptor ige plays important role controlling activity allergen specific cells ige facilitated allergen presentation objective sought determine number molecules immune cells allergic patients investigate whether number molecules antigen presenting cells associated ige levels influences allergen uptake allergen specific cell activation methods numbers molecules immune cells allergic patients quantified using flow cytometry quantibrite beads compared total allergen specific ige levels well allergen induced immediate skin reactivity allergen uptake allergen specific cell activation relation surface density determined using flow cytometry combination confocal microscopy cells transfected cell receptor specific birch pollen allergen bet respectively defined ige allergen immune complexes formed human monoclonal allergen specific ige bet results allergic patients vast majority molecules expressed naive igd cells density molecules cells number cells correlated total ige levels allergen induced skin reactions uptake allergen ige complexes cells activation allergen specific cells depended ige binding associated surface density addition monoclonal ige cultured pbmcs significantly increased expression cells conclusion surface density cells allergic patients correlated allergen specific ige levels determines allergen uptake subsequent activation cells
vortex induced vibration viv one self excited vibration limited amplitude usually occurring long slender structures lower damping nonlinear method based scanlan nonlinear vortex induced vibration model proposed paper interpreting test results section model prototype structure partial correlation vortex induced aerodynamic force along span considered method identifying method parameters semi empirical mathematic model improved validity proposed theory confirmed section model tests observed results field long span suspension bridge elsevier ltd rights reserved
self consistent mean field theory introduced used investigate thermodynamics spin dynamics quantum spin system magnetic skyrmion temperature dependence skyrmion profile well phase diagram calculated addition spin dynamics magnetic skyrmion described solving time dependent schrdinger equation additional damping term skyrmion annihilation process driven electric field used compare trajectories quantum mechanical simulation semi classical description spin expectation values using differential equation similar classical landau lifshitz gilbert equation
traditionally context alzheimer disease apolipoprotein epsilon apoe epsilon allele protective factor apoe epsilon allele destructive factor however inverse relationship recently challenged neural mechanisms underlying effects apoe genotype alzheimer disease remain unclear resting state functional magnetic resonance imaging study conducted investigate effects apoe genotype age amygdala functional connectivity afc networks patients amnestic mild cognitive impairment cognitively normal order adults results indicated apoe epsilon apoe epsilon alleles produced convergent effects right afc network divergent effects left afc network age increased apoe epsilon carriers showed stable afc whereas apoe epsilon carriers exhibited decreased afc participants furthermore mediation analysis revealed connectivity strength regulates effects apoe genotype age cognitive function amnestic mild cognitive impairment patients findings suggest apoe epsilon apoe epsilon alleles produce convergent divergent topological effects brain function elsevier inc rights reserved
aim study evaluate diagnostic performance point shear wave elastography using arfi technique elastpq patients chronic hepatopathies using transient elastography reference method since validated method liver fibrosis assessment subjects methods study included consecutive subjects chronic hepatopathies hbv hcv liver cirrhosis liver stiffness evaluated session means elastographic methods fibroscan echosens elastpq affinity philips techniques valid measurements performed patient median value calculated reliable measurements probe considered median value measurements success rate interquartile range kpa severe fibrosis kpa liver cirrhosis kpa tsochatzis areas receiver operating characteristic curve aurocs used assess diagnostic performance elastpq correlations elastpq evaluated results valid measurements obtained cases means cases elastpq final analysis patients included elastpq values ranged kpa median kpa based cut values tsochatzis divided cohort groups best cut values discriminating significant severe fibrosis cirrhosis kpa respectively aurocs calculated considering reference method significant fibrosis severe fibrosis cirrhosis cohort strong correlation measurements obtained transient elastography elastpq conclusions elastpq seems good diagnostic accuracy staging liver fibrosis elsevier rights reserved
background objective unclassifiable disease chronic interstitial lung disease ild common challenging problem insufficiently studied update international multidisciplinary classification idiopathic interstitial pneumonias presented classification based observed disease behaviour purpose providing guidance clinicians management patients aim study apply new disease behaviour classification dbc previously validated ild gender age physiology gap score cohort unclassifiable ild patients assess prognostic value two composite approaches methods unclassifiable ild patients identified population based ild registry aarhus university hospital denmark includes ild patients diagnosed department dbc assessed retrospectively based clinical presentation diagnostic examinations presentation short term follow results unclassifiable ild diagnosed cohort survival unclassifiable ild intermediate idiopathic pulmonary fibrosis ipf non ipf controls idiopathic nonspecific interstitial pneumonia nsip hypersensitivity pneumonitis connective tissue disease associated ild dbc ild gap index strong individual predictors outcome dichotomized regression model hazard ratio dbc ild gap approaches remained significant common regression model dbc ild gap conclusion dbc approach showed strong prognostic value unclassifiable ild dbc ild gap complementary predictors outcome unclassifiable ild
ileus continues common consequence abdominal surgery causing significant patient discomfort often leading serious problems therapy available limited hence ileus remains important clinical problem activation inducible nitric oxide synthase inos directly modulates intestinal dysmotility bowel manipulation plays essential role initiating intestinal inflammation nuclear factor kappa known critical component inos gene transcriptional activation response inflammatory stimuli bromelain crude extract pineapple stem sold nutritional supplement promote digestive health anti inflammatory medication developed countries found oral administration bromelain improves decrease defecation abdominal postoperative rats results showed bromelain increased wet weight dry weight water content number fecal pellets laparotomized plus mechanically manipulated rats suggesting improvement postoperative ileus furthermore bromelain treatment inhibited overexpressed inos mrna restored regulated inhibitor kappa alpha mrna colon postoperative rats vitro experiments bromelain inhibits lipopolysaccharide lps induced nitrite overproduction macrophage cell lines lps induced kappa luciferase reporter gene expression raw macrophages transfected kappa luciferase reporter gene thus findings suggest bromelain improves decrease defecation postoperative rats least part inhibiting colonic inos overexpression via kappa pathway data indicates bromelain may benefit patients postoperative ileus elsevier inc rights reserved
several researchers observed environmental enrichment effective reducing stressful conditions abnormal behavior may provide better reproductive performance rodents context study aimed evaluate reproductive performance wistar rats reared three different housing conditions animals separated breeding pairs one pair per cage pairs randomly assigned three experimental groups ten couples per group control group provided cages without environmental enrichment pvc group pvc pipe cardboard roll group commercially available cardboard tube compare reproductive performance three groups following evaluated number pups litter number litters parturition interval occurrence cannibalism weight gain offspring well quantity quality cumulus oocyte complexes cocs obtained superovulation females born first second last pregnancy groups moreover plasma level corticosterone breeding animals measured total male rats randomly selected first last born litters males group first tested elevated plus maze epm following day tested open field test oft significant differences found number morphological classification cocs control group number oocytes grade unusual shapes heterogeneous ooplasm presenting layers surrounding cumulus cells presented statistically higher rates compared groups well number competent oocytes higher enriched groups moreover find males cardboard roll group differed significantly weight gain compared pvc group addition detect occurrence cannibalism group findings suggest environmental enrichment provides improvements reproductive performance wistar rats elsevier inc rights reserved
strong board magnet moved relative conducting sheet circulating eddy current induced conductor eddy current turn produces magnetic field lorentz force law produces repulsive forces two magnetic fields experimental study electrodynamic suspension system carried diameter rotary type test wheel two types board magnets tested one htsc magnet one halbach arrayed permanent magnet lorentz forces two eds systems measured compared theoretical numerical calculations
pathogenicity different flu species real public health problem worldwide combat scourge established method detect drug targets reducing possibility escape besides able attach drug candidate targets main characteristic part essential viral function invariance groups sets residues bearing essential function detected genetically consist invariant synthetic lethal residues interdependent residues varying slightly varying together analyzed alignment hemagglutinin sequences influenza detect six invariance groups close space protein surface parallel identified five potential pockets surface hemagglutinin combining results three potential binding sites determined composed invariance groups located respectively vestigial esterase domain bottom stem fusion area latter target constituted residues involved spring loaded mechanism essential step fusion process propose model describing potential target could block reorganization hemagglutinin secondary structure prevent viral entry host cell
purpose review review recent literature regard patient satisfaction overactive bladder treatments latest research looks beta agonist mirabegron treat oab sacral pudendal neuromodulation severe oab conservative management effectively alleviated oab symptoms without adverse effects antimuscarinic medications pfme appears successful treatment medical management continues show efficacy bothersome side effects substantial proportion patients significant cost leading medical noncompliance discontinuation therapy btx injections neuromodulation also quite efficacious third line treatment option refractory oab patients patients longer candidates second line therapy
graph databases defined databases use graph structures nodes edges properties store data semantic queries graph oriented operations used access rapidly growing amount information internet recent years relational databases sur performance degradation large number nodes added due number entries join tables therefore based network nature internet activities graph databases designed fast access complex data found social networks recommendation engines networked system main objective survey present work done area graph database including query languages processing related application
model order reduction mor techniques play crucial role computer aided design modern integrated circuits used reduce size parasitic networks unfortunately efficient reduction passive networks many ports still open problem existing techniques scale well number ports lead dense reduced models burden subsequent simulations paper propose turbomor novel mor technique efficient reduction passive networks turbomor based moment matching achieved efficient congruence transformations based householder reflections novel feature turbomor block diagonal structure reduced models makes efficient dense models produced existing techniques moreover model structure allows insightful interpretation reduction process terms system theory numerical results show turbomor scales favorably existing techniques terms reduction time simulation time memory consumption
exposure androgens prenatal development shapes physiological behavioral developmental trajectories notably rhesus macaques prenatal androgen exposure shown increase rough tumble play prominent behavioral feature males juvenile period primates macaques old world polygamous species marked sexually dimorphic behavior new world callitrichine primates marmosets tamarins live cooperative breeding groups considered socially monogamous exhibit minimal sexual dimorphism social play suggests androgen may affect species different ways compared macaques addition previously described considerable variation maternal androgen production gestation marmosets tested association variation variation offspring rough tumble play patterns males females measured testosterone androstenedione levels urine samples collected pregnant marmoset mothers observed offspring play behavior juveniles months age contrast findings rhesus macaques hierarchical regression analyses showed higher gestational testosterone levels primarily second semester associated decreased rough tumble play juveniles relationship appears driven males females found reliable associations gestational androstenedione juvenile play behavior findings provide evidence suggest normative variation levels maternal androgen gestation may influence developmental behavioral trajectories marmosets way contradicts previous findings old world primates published elsevier inc
turmeric used traditional medicine centuries treat range ailments primary active constituent curcumin influence array biological activities many anti inflammatory antioxidant neuroprotective monoaminergic effects dysregulated several neuropsychiatric disorders systematic review vitro animal human studies investigating potential curcumin treatment neuropsychiatric disorders major depressive disorder post traumatic stress disorder ptsd obsessive compulsive disorder ocd bipolar disorder psychotic disorders autism reviewed directions future research proposed concluded curcumin promising natural agent many conditions however research utilising robust clinical designs essential problem associated poor oral bioavailability standard curcumin also requires consideration currently greatest support efficacy curcumin treatment major depressive disorder
performance fuse electronic components may degradation long term storage order certain components performance degradation two fuse electronic parts stored years chosen samples accelerated test shows white noise resistance interfering noise different resistances may lead performance degradation zero drift due brokenness bonding wire may magnify noise voltage storage influence reliability operational amplifier result indicates resistances operational amplifiers concerned test fuse electronic device long storage
developing axons locally synthesize proteins roles axon growth guidance regeneration mechanisms regulate axonal mrna translation well understood micrornas mirnas important regulators translation still little characterized developing axons study mouse dorsal root ganglion drg axons show extension impaired conditional deficiency mirna processing enzyme dicer vitro vivo screen axonal localization identifies specific set mirnas preferentially enriched within developing axon high axonal expression preferential localization observed mir mirna previously known roles dendrites dysregulation major neurologic diseases mir knockdown reduced extension cultured drg axons whereas overexpression increased extension mechanistically mir regulated mrna ras gtpase activator rasa novel target neuronal function moreover mir regulation rasa translation seen severed axons demonstrating mirna function locally within axon mir expression drgs peaked period maximum axon growth vivo consistent effect axon growth suggesting role developmental timer together findings identify mir positive regulator developing axon extension acting repression rasa mrna mechanism operates locally within axon
paper compact lightweight switching system wearable microwave imaging device proposed switching system provides wideband performance covers frequency ranges ghz low power microcontroller integrated switch act control unit using bluetooth connection switching system controlled using android mobile phone array eight uwb monopole antennae connected proposed system overall performance evaluated measured insertion losses port show average loss ghz impedance matching antennae measured return loss values ghz ghz size circuit
harsh service environment degenerates performance bridges even leads catastrophic collapse structural temperature widely recognized one negative environmental effects bridges structural responses deeply affected variation distribution temperatures bridges therefore identifying correlations significant issue structural safety assessment study relationships temperature induced static response surrounding weather factors investigated based long term field measurements long span suspension bridge correlations meteorological parameters bridge filed nearby weather station relations structural static responses air temperature investigated results indicate relationships meteorological parameters nearby weather station bridge field predicted correlation static responses air temperature remarkable high correlation coefficient conclusions expected provide reference design evaluation long span suspension bridges
investigate potential various metrics derived mono exponential model mem exponential model bem stretched exponential model sem based diffusion weighted imaging dwi diagnosing differentiating pathological subtypes grades uterine cervical carcinoma newly diagnosed patients cervical carcinoma cases squamous cell carcinoma scc cases adenocarcinoma healthy volunteers received dwi multiple values apparent diffusion coefficient adc pure molecular diffusion pseudo diffusion coefficient perfusion fraction water molecular diffusion heterogeneity index alpha distributed diffusion coefficient ddc calculated compared tumour normal cervix among different pathological subtypes grades parameters significantly lower cervical carcinoma normal cervical stroma except alpha scc showed lower adc ddc values higher value ddc values scc adc values lower poorly differentiated group well moderately differentiated group compared mem diffusion parameters bem sem may offer additional information cervical carcinoma diagnosis predicting pathological tumour subtypes grades showed promising significance aeuro cent dwi derived parameters different models related provide diversified information aeuro cent commonly used adc mem dwi overestimates tissue water diffusivity aeuro cent dwi processed bem could separate blood perfusion true diffusion effects aeuro cent derived diffusion related perfusion related parameters bem superior adc
paper show thoughtful reusing libraries provide concise proofs non trivial mathematical results concretely formalise isabelle hol proof fundamental theorem linear algebra vector spaces inner product spaces gram schmidt process orthogonalising vectors application get decomposition matrix least squares approximation systems linear equations without solution modest number lines work intensively reuses previous results rank nullity theorem various applications gauss jordan algorithm formalisation also accompanied code generation refinements enable execution presented algorithms isabelle sml
investigation paper dimensional generalized nonlinear schrodinger equation distributed coefficients spatiotemporal optical soli tons light bullets symbolic computation hirota method one two soliton solutions derived also present backlund transformation derive soliton solutions gain loss coefficient monotonically decreasing function propagation coordinate amplitude spatiotemporal optical soliton light bullet decreases along gain loss coefficient monotonically increasing function amplitude spatiotemporal optical soliton light bullet increases along directions solitons different signs imaginary parts frequencies adverse based two soliton solutions elastic inelastic collisions two spatiotemporal optical solitons light bullets derived different conditions presented paper
objective examine value posttraumatic headaches predicting return work rtw patients mild traumatic brain injury mtbi setting participants total participants recruited outpatient head injury rehabilitation center british columbia canada design logistic regression analyses secondary data main measure numerical pain rating scale nprs measure headache intensity nine resulting nprs scores used predict successful versus unsuccessful rtw results largest effect size odds ratio exp value indicated odds returning work successfully cut half unit increase nprs rating conclusion author knowledge first study impact headache intensity rtw patients withmtbi posttraumatic headache severity mtbi taken account developing models predict rtw population headache intensity may act confounding variable least injury characteristics cognitive functioning may add inconsistencies tbi mtbi literature results may utilized guide rehabilitation efforts planning rtw patients mtbi
background metabolic syndrome also known syndrome insulin resistance syndrome deadly quartet constellation metabolic abnormalities includes insulin resistance glucose intolerance central obesity dyslipidaemia hypertension well documented risk factors cardiovascular disease grouped together associated increased risk cardiovascular disease concept metabolic syndrome exists least years first described kelin swedish physician clustering hypertension hyperglycaemia gout overt hypothyroidism associated parameters metabolic syndrome except increase fasting blood glucose objectives study study prevalence thyroid dysfunction newly detected metabolic syndrome patients find correlation thyroid dysfunction metabolic syndrome parameters materials methods cross sectional study conducted institute diabetology madras medical college government general hospital period months results total number participants study number study group females males analysis people thyroid dysfunction positive represents percentage prevalence hypothyroidism overt hypothyroidism subclinical hypothyroidism metabolic syndrome patients one study subject among metabolic syndrome found subclinical hyperthyroidism overt hyperthyroidism patients study correlation coefficient values tsh metabolic parameters significant study conclusion one sixth metabolic syndrome patients every sixth metabolic syndrome hypothyroidism either overt subclinical exclude presence thyroid dysfunction managing metabolic syndrome patients
important issue ambient intelligence ami massive deployment intelligent agents embedded environment adaptive users profiles preferences needs use agent oriented methodologies frameworks almost mandatory easily develop software ami scenarios icaro software framework promotes use different organizational behavioral patterns implement multi agent systems mas extensive use several projects demonstrates substantial increase software productivity also order reduce coding effort usual design mas higher level sense code generation mas specifications icaro framework performed ingenias development kit idk supports specification mas models including feature required implement mas icaro set facilities code generation paper describes development ami applications thanks integration icaro idk two idk modules developed namely code generation code update support module
research focuses improving relational databases design novice designers teaching conceptual data modelling challenge information systems educators goal test effectiveness learning errors approach area conceptual data modelling relational databases understanding difficulties novice designers encounter activity conceptual modelling analyzed students solutions course exercise form textual scenario mapped errors categories next phase intend design learning lessons activities utilize errors learning process design experiment compares traditional database teaching approach combination traditional approach learning errors approach test effectiveness latter
scientific technological application challenges arise mutual interaction developmental robotics computational human behavior understanding give rise two different perspectives robots need capable learn dynamically incrementally interpret thus understand multimodal human behavior means behavior analysis performed developmental robotics hand behavior analysis also performed developmental robotics since developmental social robots offer stimulating opportunities improving scientific understanding human behavior especially allow deeper analysis semantics structure human behavior contributions special issue explore two perspectives
study wave propagation draining bathtub black hole analogue fluid mechanics whose perturbations governed klein gordon equation effective lorentzian geometry like kerr spacetime draining bathtub geometry possesses effective horizon ergosphere null circular orbits propose pulse disturbance may used map light cone effective geometry first apply eikonal approximation elucidate link wavefronts null geodesic congruences raychaudhuri equation next solve wave equation numerically time domain using method lines starting gaussian initial data demonstrate pulse propagate along null congruence thus trace light cone effective geometry new results reveal features wavefront intersections frame dragging winding interference effects closely associated presence null circular orbits ergosphere
wind induced earthquake induced excitations tall structures effectively controlled tuned liquid damper tld work presents numerical simulation procedure study performance tuned liquid tank structure system sigma transformation based fluid structure coupled solver based computational code developed structural equations coupled fluid equations order achieve transfer sloshing forces structure damping structural equations solved fourth order runge kutta method fluid equations solved using fmite difference based sigma transformed algorithm code validated previously published results minimum displacement structure observed resonance condition coupled system satisfied proper tuning tld since real time excitations random nature performance study tld random excitation also carried bretschneider spectrum used generate random input wave
number applications need process data continuously long periods time increased significantly recent years emerging internet things smart cities scenarios also confirm requirement real time large scale data processing data multiple sources processed shared distributed computing infrastructure necessary provide quality service qos guarantees data stream specified service level agreement sla slab identify price user must pay achieve required qos penalty provider pay user case qos violation assuming maximization revenue cloud provider objective must decide streams accept storage analysis many resources allocate stream real time requirements demand rapid reaction dynamic resource provisioning policies mechanisms may useful since delays overheads incurred might high alternatively idle resources initially allocated streams could allocated avoiding subsequent penalties paper propose system architecture supporting qos concurrent data streams composed self regulating nodes node features envelope process regulating controlling data access resource manager enable resource allocation selective sla violations maximizing revenue resource manager based shared token bucket enables redistribution unused resources amongst data streams dynamic allocation resources streams likely generate greater profit provider extend previous work providing petri net based model system components evaluate approach opennebula based cloud infrastructure elsevier rights reserved
use electric vehicles begun increase ratio electric vehicles continually increase due environmental regulations speed torque characteristic electric motor better combustion engine vehicle driving due high torque low speed range however efficiency motor declines low speed range therefore electric vehicle climbs steep slope slowly severe heat may generated due high current low efficiency range regard driving high efficiency electric vehicles also require mechanical multispeed transmissions conventional mechanical multispeed transmission bulky heavy energy consuming paper suggests speed transmission using dual electricmotors one way clutches transmission structure simple enough used wheel drive unit actively moved clutches resulting high reliability eliminating need energy move clutches speed changes operational principle explained prototype experimental results presented
background stroke rehabilitation improves functional recovery among stroke patients however little known clinical practice china regarding assessment provision rehabilitation among patients acute ischemic stroke aims examined frequency determinants assessment rehabilitation among acute ischemic stroke patients china national stroke registry methods data acute ischemic stroke patients admitted hospitals june january analyzed multivariable logistic regression model generalized estimating equation method accounting hospital clustering used identify patient hospital factors associated rehabilitation assessment acute hospitalization results among acute ischemic stroke patients assessed rehabilitation rates rehabilitation assessment varied among hospitals iqr multivariable analysis factors associated increased likelihood rehabilitation assessment included disability prior stroke higher nihss admission receipt dysphagia screen deep venous thrombosis prophylaxis carotid vessel imaging longer length stay treatment hospital higher number hospital beds per units contrast patients history atrial fibrillation hospitals higher number annual stroke discharges per patients less likely receive rehabilitation assessment acute stroke hospitalization conclusions rehabilitation assessment among acute ischemic stroke patients suboptimal china rates varied considerably among hospitals support need improve adherence recommended care stroke survivors
propose ultra lightweight compact low power block cipher boron boron substitution permutation based network operates bit plain text supports key length bits boron compact structure requires gate equivalents ges bit key ges bit key boron cipher includes shift operators round permutation layers xor operations unique design helps generate large number active boxes fewer rounds thwarts linear differential attacks cipher boron shows good performance hardware software platforms boron consumes less power compared lightweight cipher led higher throughput compared existing network ciphers also present security analysis boron performance ultra lightweight compact cipher boron well suited cipher design applications small footprint area low power dissipation play crucial role
background aimantibiotic allergies frequently reported significant impacts upon appropriate prescribing clinical outcomes surveyed infectious diseases physicians allergists clinical immunologists hospital pharmacists evaluate antibiotic allergy knowledge service delivery australia new zealand methodsan online multi choice questionnaire developed endorsed representatives australasian society clinical immunology allergy ascia australasian society infectious diseases asid item survey distributed april members ascia asid society hospital pharmacists australia royal australasian college physicians resultsof respondents currently use would utilise antibiotic allergy testing aat reported seeing patients week labelled antibiotic allergic forty two per cent aware aat available felt aat would aid antibiotic selection antibiotic appropriateness antimicrobial stewardship respectively patients histories immediate hypersensitivity likely referred delayed hypersensitivities lack specialist physicians personal experience barriers service delivery multidisciplinary approach preferred aat model knowledge gaps identified majority overestimating rates penicillin cephalosporin penicillin carbapenem penicillin monobactam cross reactivity conclusionsa high burden antibiotic allergy labelling demand aat complicated relative lack availability awareness aat services australia new zealand antibiotic allergy education deployment aat accessible community hospital based clinicians may improve clinical decisions reduce antibiotic allergy impacts collaborative approach involving infectious diseases physicians pharmacists allergists immunologists required
order maximise wind energy capture wind turbines operated variable speeds depending wind speed turbine switches two operating modes low wind speed mode high wind speed mode low wind speed mode control objective maximise wind energy capture controlling blade pitch angle electrical generator torque high wind speed mode control goal maintain rated power generation adjusting blade pitch angle paper establishes stability criteria switching operation wind turbines using graphics gain nonlinear control framework also performance wind turbine system analysed using step response well known measure second order linear systems
process model guidance important feature software process orchestrated without complying guidance production lifecycle deviates producing reliable software high quality standards usually teams break process deliberately impulsively application lifecycle management alm tools log teams even break process log file could key discover behavior undertaken process targeted process model since date introduction process mining techniques used business process domains focus software engineering processes research brings process mining techniques software engineering domain research shows conclusive effort used scrum adapted process model example agile adoption research applied process mining discovery techniques capture actually implemented process scrum team application clarifies gap standard process guidance actually implemented one research results showed process mining techniques ability discover verify deviation levels process well work items state machine workflows
paper offline approach output bayesian identification stochastic nonlinear systems presented approach based parameterization joint posterior distribution parameters define postulated state space stochastic model class parameterization state predictive distribution included marginalized estimated recursively state estimation step using unscented kalman filter bypassing state augmentation required existing online methods applications expectations functions parameters interest requires evaluation potentially high dimensional integrals markov chain monte carlo adopted sample posterior distribution estimate expectations proposed approach suitable nonlinear systems subjected non stationary inputs whose realization unknown modeled stochastic processes numerical verification experimental validation examples illustrate effectiveness advantages approach including increased numerical stability respect augmented state unscented kalman filtering avoiding divergence estimates forcing input unmeasured ability handle arbitrary prior posterior distributions experimental validation approach conducted using data large scale structure tested shake table shown approach robust inherent modeling errors desdription system forcing input providing accurate prediction dynamic response excitation history unknown elsevier ltd rights reserved
organisms respond climate change winter depends snow cover subnivium insulated thermally stable area snowpack frozen ground provides refuge plants animals microbes satellite data characterizing either freeze thaw cycles snow cover available two types data yet combined map subnivium characterized global patterns frozen ground without snow cover provide baseline assess effects future winter climate change organisms depend subnivium analyzed two remote sensing datasets modis snow cover product nasa measures global record daily landscape freeze fhaw status dataset derived ssm ssmis developed new resolution dataset captures global patterns duration snow covered ground duration snow free frozen ground wos also quantified wos vary latitude results show mean interannual variation wos change latitude topography mean increases latitude counter intuitively though wos longest duration degrees decreasing northward southward even though duration frozen ground either snow covered shorter higher latitudes occurs snow cover mid latitudes low ephemeral leaving longer periods frozen snow free ground interannual variation increased latitude slopes relationship differed among north america europe asia southern hemisphere overall results show organisms rely subnivium survive winter mid latitude areas could functionally colder either higher lower latitudes furthermore interannual variation wos greater high latitudes would expect organisms adapted unpredictability exposure freezing ultimately effects climate change organisms winter considered context subnivium warming could make northerly areas functionally colder winter changes annual variation duration snow free frozen conditions could lead greater unpredictability onset end winter elsevier inc rights reserved
background growing emphasis self monitoring applications allow patients measure physical health parameters prerequisite achieving positive effects patients willingness self monitor controllability disease types patients perceived self efficacy health problems could play essential role purpose study investigate relationship patients willingness self monitor range disease patient specific variables including controllability disease type patients perceived self efficacy health problems methods data regarding participants chronic somatic disease types dutch panel people chronic diseases used cross sectional study perceived self efficacy assessed using general self efficacy scale perceived health problems using physical health composite score pcs participants indicated willingness self monitor expert panel assessed chronic disease types extent patients independently keep disease control logistic regression analyses conducted results patients willingness self monitor differs greatly among disease types patients diabetes asthma hypertension willing self monitor contrast patients rheumatism migraine neurological disorders less willing self monitor seems might relationship disease controllability scores patients willingness self monitor evidence found relationship general self efficacy pcs scores patients willingness self monitor conclusions study provides first evidence patients willingness self monitor might associated disease controllability research investigate association deeply focus disease controllability influences willingness self monitor addition since willingness self monitor differed greatly among patient groups taken account patient groups willing self monitor
background intracranial dural arteriovenous fistulae davf may present treatment challenge endovascular embolization cases first line treatment always achieve cure gamma knife radiosurgery represents alternative treatment option purpose study evaluate utility methods reviewed cases davf treated institution radiosurgery independently following failed refused endovascular surgical management patients clinical files radiological images catheter angiograms surgical davf disconnection reports retrospectively reviewed results sixteen davf patients treated radiosurgery identified eleven fistulae aggressive five benign marginal doses ranged target volumes ranged symptomatic patients treatment resulted symptom palliation lesions cure symptoms reported one lesion asymptomatic angiographic cure achieved eight cases small residual davf occurred four four unchanged one patient developed headache resolved one year hemorrhage occurred follow period significant association borden type cure rate prior failed endovascular treatment small target volume associated lower rates cure conclusions stereotactic radiosurgery viable treatment davf effective palliating symptoms novo approach adjunctive endovascular therapy experience somewhat effective achieving complete angiographic cure
gender regime change regarded inevitable global process today status women unprecedentedly becomes barometer societies measure advancement civilizations contemporary international gender regime based system called modern values historical records indicate united states prominent defining global status women norms mechanisms present study takes hillary clinton tenure department state synopsis american history status women became cornerstone american foreign policy delves concept hillary effect definitive factor engagement policy muslim women middle east north africa argument employs academic exchanges university oriented programs mobilize new generations muslim women scholars sources change democratization region two major projects including techwomen nexxt scholars initiative examined case studies give overview major educational strategies overseas results indicate mentioned strategies include inspiring women future leadership democratization prioritizing english language medium communicate setting programs based bilateral willingness inspiring sense empowerment expanding membership finally nurturing sense belonging american culture political thought elsevier ltd rights reserved
optical fiber bragg grating fbg displacement sensors play important role various areas due high sensitivity displacement however becomes serious problem fbg cross sensitivity temperature displacement applications fbg displacement sensing paper presents method temperature insensitive measurement displacement via using appropriate layout sensor displacement sensor constructed two fbgs mounted opposite surface cantilever beam wavelengths fbgs shift horizontal direction displacement acting cantilever beam displacement measurement achieved demodulating wavelengths difference two fbgs case difference two fbgs wavelengths taken order compensate temperature effects four cantilever beams different shapes designed fbg strain distribution quite different deformation strain distribution cantilever beams simulated using finite element analysis used optimize layout fbg displacement sensor experimental results show obvious increase sensitivity change displacement obtained temperature dependence greatly reduced change wavelength found increase displacement cantilever beam physical size fbg displacement sensor head adjusted meet need different applications structure health monitoring smart material sensing aerospace etc
context switch essential feature modern operating systems purpose context switch provide concurrency processing multiple programs however backup reload procedures due context switch time consuming work propose racetrack memory sram hybrid rsh cell design used replace current sram cells caches reduce overhead context switch using rsh reduces overhead context switch average area overhead compared traditional sram designs
rhythmic auditory cueing well accepted tool gait rehabilitation parkinson disease applied performance adapted fashion due technological advance study investigated immediate differences gait prolonged min walk performance adapted intelligent auditory cueing verbal feedback provided wearable sensor based system alternatives traditional cueing additionally potential effects self perceived fatigue assessed twenty eight people age matched healthy elderly performed four min walks wearable cue feedback system randomized order participants received continuous auditory cueing intelligent cueing metronome beats triggered deviating walking rhythm intelligent feedback verbal instructions triggered deviating walking rhythm external input fatigue self scored rest walking session results showed able maintain cadence min conditions cadence significantly declined without input continuous cueing intelligent feedback people able maintain cadence although physically fatigued furthermore cadence deviated significantly people without input particularly intelligent feedback continuous intelligent cueing induced significantly less deviations cadence altogether suggests intelligent cueing suitable alternative continuous mode prolonged walking induced similar effects gait without generating levels fatigue beyond
study investigated driving mechanism building interaction ties among people living hiv aids one largest virtual hiv communities china using social network analysis specifically explained probability forming interaction ties homophily popularity characteristics exponential random graph modeling results showed members community tend form homophilous ties terms shared location interests moreover found tendency away popularity effect suggests community resources information disproportionally received members could beneficial overall community
post transplantation cyclophosphamide ptcy used graft versus host disease gvhd prophylaxis alone combination agents associated excellent rates engraftment acute chronic gvhd well absence post transplantation lymphoproliferative disease study previously evaluated risk developing donor derived malignancy ddm patients receive ptcy giving chemotherapy immediate post transplantation period carries theoretic risk disturbing graft time increased hematopoietic stress causing accelerating development malignancy patients underwent allogeneic transplantation received ptcy johns hopkins hospital cases ddm identified among large population similar rate ddm published literature found estimated cumulative incidence competing risk analysis ddm use ptcy appear increase risk ddm american society blood marrow transplantation published elsevier inc rights reserved
background cortical subcortical cognitive impairments found dementia lewy bodies dlb roughly comprise visuoconstructive executive dysfunction whereas memory would remain relatively spared however cognitive profile patients prodromal dlb remains poorly illustrated date methods included patients prodromal dlb age years men mini mental state examination mmse score healthy control subjects hcs age years men mmse score presented extensive neuropsychological test battery assess memory speed processing executive function visuoperceptual visuospatial visuoconstructive abilities language social cognition results compared hcs patients lower scores visual recognition memory test delayed matching sample items lower free recall total recall performance verbal episodic memory test free cued selective reminding test short term memory working memory scores also lower patients assessment executive function showed slowing overall lower performance patients hcs whereas assessment instrumental function yielded mixed results indeed patients lower scores language tests apraxia pantomime tool use imitation meaningless gesture well weakened visuospatial abilities visuoconstruction also impaired patients however visuoperceptual abilities differ groups finally theory mind abilities lower patients hcs emotion recognition abilities similar conclusions study presents cognitive profile patients prodromal dlb line literature dlb dementia results show lower performance tests executive function visuoconstruction however found prodromal stage dlb memory free recall visual recognition social cognition deficits well weakened visuospatial praxic abilities
electrical impedance spectroscopy usually requires wide bandwidth current source high output impedance non idealities operational amplifier amp degrade performance work presents particle swarm algorithm extracting main characteristics amp used design mirrored modified howland current source circuit satisfies output current impedance spectra required user specifications accommodated resistive biological loads used simulations results showed algorithm correctly identify open loop gain input output resistance amp best fit performance requirements circuit also shown higher open loop gain corner frequency higher output impedance circuit algorithm could powerful tool developing desirable current source different bioimpedance medical clinical applications cancer tissue characterisation tissue cell measurements
office buildings constitute significant proportion non residential building stock recent years various rating tools developed foster green office building development green building council australia gbca developed green star office rating tools purpose increasing number stakeholders adopting tools showcase efforts sustainable development research focuses challenges barriers obtaining gbca ratings australian office buildings accomplish scoring sheets rating certified office buildings collected critically analysed findings indicated credits related attributes innovation ecology energy comparatively difficult achieve also found study large number projects apply specific credits refrigerant global warming potential use facade topsoil fill removal site individual comfort control study provides useful reference property developer green building council australia green building developments future particular findings provide useful inputs development next generation green building rating tools
paper presents capacitive obstacle rectangular waveguide filters capable realizing multiple transmission zeros tzs combining capacitive window multiple thin stubs filter designer ability control total coupling implemented obstacle frequency location tzs generated resulting structure compact employed input output intermediate stages direct coupled resonator filters letter includes parametric analysis obstacle practical design guidelines validate practical application line five pole filter realizing three tzs successfully realized
pancreatic cancer highly lethal disease limited therapeutic options available pancreatic cancer exhibits pronounced collagen rich stromal reaction induces chemoresistance inhibiting drug diffusion tumor complementary treatment oncolytic virus oncolytic adenovirus expressing relaxin ydc innovative treatment option combating chemoresistant pancreatic cancer examined ability combined treatment gemcitabine ydc degrades extracellular matrix ecm efficiently treat chemoresistant desmoplastic pancreatic cancer gemcitabine alone exhibited similarly low cytotoxicity toward pancreatic cancer cells throughout concentration range used whereas combination ydc sub therapeutic dose gemcitabine resulted potent anticancer effects effective induction apoptosis importantly ydc combined gemcitabine significantly attenuated expression major ecm components including collagens fibronectin elastin tumor spheroids xenograft tumors compared gemcitabine alone resulting potent induction apoptosis gemcitabine mediated cytotoxicity oncolytic effect degradation tumor ecm results demonstrate ydc selectively degrade aberrant ecm attenuate ecm induced chemoresistance observed desmoplastic pancreatic tumor resulting potent antitumor effect effective induction apoptosis elsevier rights reserved
regression analysis machine learning approach aims accurately predict value continuous output variables certain independent input variables via automatic estimation latent relationship data tree based regression models popular literature due flexibility model higher order non linearity great interpretability conventionally regression tree models trained two stage procedure recursive binary partitioning employed produce tree structure followed pruning process removing insignificant leaves possibility assigning multivariate functions terminal leaves improve generalisation work introduces novel methodology node partitioning single optimisation model simultaneously performs two tasks identifying break point binary split assignment multivariate functions either leaf thus leading efficient regression tree model using six real world benchmark problems demonstrate proposed method consistently outperforms number state art regression tree models methods based techniques average improvement mean absolute errors mae predictions authors published elsevier ltd
urban areas need pursue new water servicing options ensure local supply security decisions best employ straightforward due multiple considerations potential problem shifting among hypothesise urban water metabolism evaluation based water mass balance help address explore utility perspective new insights provides water servicing options using water mass balance evaluation framework considers direct urban water flows natural hydrological anthropogenic flows well water related energy evaluated use alternative water sources stormwater rainwater harvesting wastewater greywater recycling different scales influences local water metabolism case study urban development new indicators devised represent water related resource efficiency hydrological performance urban area new insights gained extent alternative water supplies influence water efficiency hydrological performance urban area potential energy trade offs novel contribution development new indicators urban water resource performance bring together considerations anthropogenic natural water cycles interactions used first time test alternative water servicing scenarios provide new perspective complement broader sustainability assessments urban water elsevier ltd rights reserved
wind turbine generators wtgs consist many different components convert kinetic energy wind electrical energy end users wind energy accessed provide mechanical torque driving shaft electrical generator conversion wind power mechanical power governed aerodynamic conversion aerodynamic electrical conversion efficiency wtg influenced efficiency blades gearbox generator power converter paper describes use matlab simulink simulate electrical grid related aspects wtg coupled fast aeroelastic wind turbine computer aided engineering tool simulate aerodynamic mechanical aspects wtg combination two enables studies involving electrical mechanical aspects wtg example mechanical engineers formulate generator control may preserve life gearbox mitigate impact transient events occurring transmission lines faults voltage frequency dips unbalanced voltages etc similarly electrical engineers study impact high ramping wind speeds power systems well impact turbulence voltage frequency small balancing authority area digest includes examples capabilities fast matlab coupling namely effects electrical faults blade moments
background healthy sleep characterized several stages wake light sws rem sleep clinical experts find breath subjects different sleep stages observation lacking data supporting statistical research investigating breathing patterns sleep process helpful sleep breathing domain objective objective paper statistically analyze respiratory characteristics different sleep stages methods firstly calculated mean value standard deviation respiratory rates stages respiratory rates obtained autocorrelation method detrended fluctuation analysis dfa algorithm applied analyze long range correlation respiratory rates sleep stages results mean standard deviation respiratory rates wake cycles per minute cpm light cpm sws cpm rem cpm respectively scaling exponent applied detrended fluctuation analysis dfa algorithm reached stage conclusion results mean standard deviation respiratory rates show different sleep stages lead different autonomic regulations breathing exhibit different respiratory rates fluctuations dfa results demonstrate respiratory rates long range correlated stages although lead different fluctuation
use social networks grown exponentially recent years large amount data available networks effectively utilized many machine learning applications paper proposes framework emotion recognition system fetches huge amount face images social networks cloud cloud problem unlabeled facial images handled applying active learning approach feature extraction interlaced derivative pattern used base classifier extreme learning machine utilized emotion recognized cloud shared end users meet interests several experiments performed using publicly available databases heterogeneous images social networks experimental results showed proposed framework may effectively used emotion recognition
case zoe year old white girl presents new patient pediatric clinic complaints frequent emesis anxiety learning problems previous diagnosis cerebellar ataxia parents accompany zoe state really hard gets sick falls easily born full term vaginal delivery without complications given globally delayed milestones received early intervention services feeding problems began infancy including gastroesophageal reflux aspiration pneumonia age zoe saw neurologist brain mri revealed cerebellar atrophy recently saw geneticist genetic studies pending parents report receiving little information regarding prognosis research read individuals similar symptoms adulthood degenerative pattern worry zoe still young know future like despite ongoing speech feeding challenges parents report difficulty finding speech language therapist area zoe see otolaryngologist frequent otitis media hearing loss ophthalmologist vision problems still continues fall behind school furthermore intensely afraid falling school friends resulting family loss regarding school lives parents healthy older sisters mother crohn disease unable work maternal aunt close zoe hypothyroidism father works insurance agent resources tight zoe mother describes making zoe movies otherwise stays home zoe usually needs assistance walk public keep stumbling parents share simply public place meeting new physician may trigger emesis zoe enjoy interacting neighborhood children says wants normal wear nail polish date seeks independence often refusing use wheelchair parents feel requires intensive occupational physical therapy examination slender hypertelorism nystagmus holding emesis bag gags intermittently producing clear secretions notable tremor walks slightly stooped wide based gait words demonstrate articulation differences cognitive expression characteristic younger child wears light make age appropriate clothes asks home end visit parents share worry zoe young know anything expect tell family new medical home ask weigh next best support begin
despite wide recognition increased social support associated positive parenting behaviors limited understanding regarding mechanisms neighborhood context increase hinder social connections sample parents franklin county study examines role availability social services child maltreatment negative binomial regression study finds greater availability social services associated lower levels child abuse neglect additionally availability social services moderates relationship social support child maltreatment relationship social support child maltreatment weaker parents neighborhoods greater availability services findings suggest increasing services awareness services might opportunity child maltreatment prevention
role restorative coupling synchronization coupled identical harmonic oscillators studied necessary sufficient conditions individual systems solutions converge common trajectory presented simple physical examples meaning limitations theorems expounded also demonstrate versatility results extended cover lti passive electrical networks one extensions generalizes well known link asymptotic stability synchronization subspace second smallest eigenvalue laplacian matrix elsevier ltd rights reserved
paper deals consumer markets sales depend production assuming firm sale proportional production shows price leader set price maximizes industry revenues market many small firms independent cost functions elsevier rights reserved
aim work study effect high pressure processing hpp allergenicity main protein involved peach allergy pru results obtained showed pressure time combinations slightly enhanced vitro ige binding peach extract moreover additional tests carried means skin prick tests peach allergic patients different vitro results vivo effects evidenced hpp mpa min either reduce increase allergenicity depending particular sensitisation patient notwithstanding variability highly remarkable skin response pressurized peach extract stronger half individuals results would suggest higher risk hpp treated peach products elicit allergenic reaction however also proved matrix plays important role peach allergenicity modification consequently investigations needed extrapolating results complex products industrial relevance peach allergy one frequent allergies mediterranean countries among adult patients however date information effect hpp peach allergenicity study increases understanding impact processing important fruit allergen order advance knowledge based ways managing allergens risks industry well opens new opportunities research technologies strategies attempt reduce peach allergenicity elsevier ltd rights reserved
smart material systems structures remarkable properties responsible application different fields human knowledge shape memory alloys piezoelectric ceramics magnetorheological fluids magnetostritive materials constitute important materials belong smart materials category shape memory alloys smas metallic alloys usually employed large forces displacements required applications aerospace structures rotordynamics several bioengineering devices investigated nowadays terms applied dynamics smas used order exploit adaptive dissipation associated hysteresis loop mechanical property changes due phase transformations paper presents general overview nonlinear dynamics chaos smart material systems built smas oscillators vibration absorbers impact systems structural systems concern results show several possibilities smas employed dynamical applications elsevier ltd rights reserved
objectives investigate potential beneficial effects posterior pericardial drainage patients undergoing heart surgery methods multiple online databases relevant congress proceedings screened randomized controlled trials assessing efficacy safety posterior pericardial drainage defined posterior pericardiotomy incision chest tube posterior pericardium primary endpoint hospital days cardiac tamponade secondary endpoints comprised death cardiac arrest early late pericardial effusion postoperative atrial fibrillation poaf acute kidney injury pulmonary complications length hospital stay results nineteen randomized controlled trials enrolled patients included posterior pericardial drainage associated significant reduction odds cardiac tamponade compared control group odds ratio confidence interval corresponding event rates versus odds early late pericardial effusion reduced significantly intervention arm respectively posterior pericardial drainage significantly reduced odds poaf associated significantly shortened nearly day overall length hospital stay reductions postoperative complications translated significantly reduced odds death cardiac arrest numerically lower odds acute kidney injury conclusions posterior pericardial drainage safe simple technique significantly reduces prevalence early pericardial effusion poaf also late pericardial effusion cardiac tamponade benefits turn translate improved survival heart surgery
already lack qualified engineers technical fields czech republic even coming years slump number engineering graduates expected reason university west bohemia pilsen faculty mechanical engineering department machine design new innovative study materials interconnected technical practice created learning materials make field machine design faculty attractive also enhance quality former students paper gives account formation application learning materials based entire design process universal center lathe paper entire structure study materials parts explained described illustrations educational materials created consultation experts design machine tools technical fields foundry industry welding engineering fem calculation engineering achieving best connection modern mechanical engineering practice
filters slowly decaying impulse responses many uses computer graphics recursive filters often fastest option cases paper derive closed form formulas computing exact initial feedbacks needed recursive filtering infinite input extensions provide formulas constant padding clamp edge periodic repeat even periodic mirror reflect extensions formulas designed easy integration modern block parallel recursive filtering algorithms new modified algorithms state art filtering images faster even previous methods ignore boundary conditions
paper presents dynamic voltage restorer dvr response study cases voltage sags occurrence electrical distribution networks connection substation topology usually voltage disturbances caused faults occur lines connected bus bar main feeder even main feeder connection substation dvr uses diode based rectifier voltage source supplied back feeder connection substation modeled matlab simulink severe faults lines adjacent main feeder back feeder also faults main feeder real impact magnitude voltage supplied end users connected electrical network downstream connection substation bus bars simulated dvr response studied fault conditions obtained results prove effectiveness chosen topology series custom power device voltage magnitude disturbances mitigation distribution networks
medicare access chip reauthorization act macra advances goal tying medicare payments quality value april cms published initial proposed rule macra renaming quality payment program qpp qpp clinicians receive payments either advanced alternative payment models merit based incentive payment system mips consolidation existing federal performance programs applies positive negative adjustments fee service payments physicians participate mips review highlights implications qpp mips radiologists although mips incorporates radiology specific quality measures radiologists also required participate practice improvement activities including patient engagement recognizing physicians unique practice patterns mips provide special considerations performance evaluation physicians limited face face patient interaction although considerations affect radiologists likelihood success qpp many practitioners ineligible considerations currently proposed criteria reporting using qualified clinical data registries benefit radiologists performance allowing expanded arrays mips non mips specialty specific measures group practice reporting option substantially reduce administrative burden introduce new challenges requiring uniform determination patient facing status performance measurement group physicians diagnostic radiologists interventional radiologists nonradiologists taxpayer identification number given initial mips performance period begins radiologists must begin preparing qpp taking actions ensure future success new quality based payment system american college radiology
backgroundin france alzheimer plan enabled development units specialized managing behavioural psychological disorders found cognitive pathologies emphasis pharmacological non pharmacological treatments aim study analyze evolution behavioural symptoms autonomy psychotropic drug prescriptions cognitive behavioural unit toulouse france methodsprospective study systematic analyze data patients hospitalized cognitive behavioral unit resultsthis year study included patients behavioural symptoms significantly improved follow period remained discharge autonomy especially walking altered prescription psychotropic drugs neuroleptics significantly lower discharge conclusionthis study showed effectiveness overall care emphasis pharmacological non pharmacological treatments managing disruptive behavioural symptoms specialized unit
people spontaneously produce gestures speaking thinking authors focus gestures depict indicate information related contents concurrent speech thought representational gestures previous research indicates gestures communicative functions also self oriented cognitive functions article authors propose new theoretical framework gesture conceptualization hypothesis explains self oriented functions representational gestures according framework representational gestures affect cognitive processes main ways gestures activate manipulate package explore spatio motoric information speaking thinking four functions shaped gesture ability schematize information focus small subset available information potentially relevant task hand framework based assumption gestures generated system generates practical actions object manipulation however gestures distinct practical actions represent information framework provides novel parsimonious comprehensive account self oriented functions gestures authors discuss framework accounts gestures depict abstract metaphoric content consider implications relations self oriented communicative functions gestures
paper addresses robust control synthesis diving climbing manoeuvres underwater vehicle vertical plane first new state space representation vehicle dynamics presented corresponding problem formulation clearly stated next two controller set using infinity loop shaping design employed deal bottom following capability robustness issues reduced order control system hankel norm evaluated frequency domain addition preview control approach used improve overall tracking performance undersea manoeuvres specific control tasks include tracking set depth profiles ocean floors simulation results show control objectives effectively accomplished spite model uncertainties finally found proposed control methodology suitable depth trajectory following applications wide range operating conditions
paper presents architecture simulation results analog part multichannel integrated circuit optical radiation sensors visible infrared light used high speed applications complete prototype called optical radiation readout circuit orrc composed analog front end moderate resolution analog digital converter adc included every channel paper focused fast analog signal processing taking account parameters pulse shaping noise performance stability issues front end part proposed composed charge sensitive amplifier csa active filter called shaper main design challenges related high repetition rate signal processing discussed detail topology circuit verified number simulations including monte carlo sessions
mode fracture one three primary macroscopic fracture modes common tensile fracture mode crack propagates direction normal applied stress micro cracks voids inclusions segregation second phases materials unavoidable affect directly strength materials hence stress fields mode crack tip became focus fracture type gurson tvergaad needleman gtn developed constitutive model taken account voids micro cracks inclusion etc materials model reasonably illustrated brittle fracture extend numerical analysis infinite plate mode crack employed gtn model conducted completed paper help fem software abaqus length crack curvature tip crack dimensions plate subjected uniform stress two ends long wide material plate typical elastic plastic materials distributions stresses strains values damage tip crack obtained fem software process propagation crack completely simulated method element failure
functional magnetic resonance imaging used identify brain based mechanisms uncertainty certainty associated answers multiple choice questions involving common misconceptions electric circuits twenty two scientifically novice participants humanities arts college students asked fmr study whether thought light bulbs images presenting electric circuits lighted correctly certain uncertain answers participants reported unsure responses analyses revealed significant activations brain areas typically involved uncertainty anterior cingulate cortex anterior insula cortex superior dorsomedial frontal cortex left middle superior temporal lobe certainty associated large bilateral activations occipital parietal regions usually involved visuospatial processing correct certain answers associated activations suggest stronger mobilization visual attention resources compared incorrect certain answers findings provide insights brainbased mechanisms uncertainty activated common misconceptions identified science education research literature interfere decision making school like task also discuss implications results educational perspective
background aims neonates born hepatitis virus hcv positive mothers usually screened hcv unscreened children may act active sources social hcv transmission factors contributing vertical hcv transmitting still remained controversial needed optimization aimed investigate factors contributing vertical hcv transmission egypt highest hcv prevalence worldwide methods prospectively followed neonates born hcv positive mother child bearing period identify mother child transmission mtct factors january march data mining computational analysis used quantify findings results among randomized pregnant women prevalence hcv hcv vertical transmission identified eight neonates high viral load identified predictor risk mtct conclusions hepatitis virus pregnancy substantial risk vertical hcv transmission high viral load hcv positive women increases risk hcv transmission neonates screening pregnant women early stage pregnancy optimizing hcv viral load hcv positive women might prevent vertical hcv transmission neonates
globalization enables transfer impacts water availability argue threat evaluated decrease quantity importantly degradation water quality exporting countries grouping world fourteen regions paper establishes multi region input output framework calculate nitrogen related grey water footprint water quality induced scarcity index caused pollution period discovered grey water embodied international trade growing faster total grey water footprint china usa india three top grey water exporters accounted half total traded grey water dilemma rose china india facing highest grey water scarcity usa biggest grey water importers alleviated water stress outsourcing water pollution structural decomposition analysis conducted study drivers evolution virtual flows grey water globalization period results show despite technical progress offset growth traded grey water structural effects globalization including evolution globalized economic system consumption structure together consumption volume made positive contribution found structural effect intensified pollution induced water scarcity exporters generally increased nations imported grey water resulting increases nations exported grey water brazil china indonesia last drawing cap trade boarder tax adjustment schemes propose policy recommendations ensure water security achieve environmentally sustainable trade sides production consumption
purpose review review addresses recent developments cockroach allergen research relation allergic diseases especially asthma recent findings number allergens relevant cockroach allergy recently expanded considerably groups new ray crystal structures allergens groups revealed interesting features implications allergen standardization sensitization diagnosis therapy summary cockroach allergy strongly associated asthma particularly among children young adults living inner city environments posing challenges disease control environmental interventions targeted reducing cockroach allergen exposure provided conflicting results immunotherapy may way modify natural history cockroach allergy decrease symptoms asthma severity among sensitized exposed individuals new information cockroach allergens important assessment allergen markers exposure disease design immunotherapy trials
context leptin produced white adipose tissue also human coronary atherosclerotic lesions objective aim study assess prognostic value leptin patients proven coronary artery disease cad methods atherogene contemporary cad cohort study median follow time quartile years results leptin concentration associated hazard ratio fully adjusted model women significant men endpoint cardiovascular death non fatal myocardial infarction observed patients conclusion women known cad increased leptin concentration useful predicting cardiovascular death non fatal myocardial infarction
background atopic dermatitis characterized intense pruritis common childhood inflammatory disease many factors known affect development including pleiotropic cytokine yet little known regarding direct effects keratinocyte function objective methods report rna sequencing functional assays used define effect allergic environment primary keratinocyte function wound repair mice results acute chronic stimulation modified expression genes expressed human keratinocytes involved broad spectrum nonoverlapping functions among induced changes repression fibronectin critically impaired human keratinocyte wound response moreover mouse models spontaneous induced like lesions delayed epithelialization importantly topical treatment fibronectin restored epidermal repair response conclusion keratinocyte gene expression critically shaped altering cell fate decisions likely important clinical manifestations pathology allergic skin disease
wearable devices monitoring food intake passive sensing slowly emerging complement self reporting users caloric intake eating behaviors though ultimate goal passive sensing eating become reliable gold standard dietary assessment currently showing promise means validating self report measures continuous food intake monitoring allows validation refusal users reported data order obtain reliable user information resulting effective health intervention services recognizing importance strength wearable sensors food intake monitoring variety approaches proposed studied recent years existing technologies show promise many challenges opportunities discussed survey still remain paper presents meticulous review latest sensing platforms data analytic approaches solve challenges food intake monitoring ranging ear based chewing swallowing detection systems capture eating gestures wearable cameras identify food types caloric content image processing techniques paper focuses comparison different technologies approaches relate user comfort body location applications medical research identify summarize forthcoming opportunities challenges wearable food intake monitoring technologies
alternative materials like recycling materials industrial products soils already influenced human activities urban soils commonly accepted building material earthwork constructions risk contaminant leaching materials limited reducing amount percolating water technical safeguards means achieve must adapted requirements road construction research project aims better knowledge percolation leaching processes road embankments constructed alternative materials different technical safeguards input behavior water contaminants used soils road runoff measured eight field lysimeters urban road enterprise zone augsburg southern germany vehicles per day lysimeter contains cut embankment technical safeguards aim decrease percolation include capillary barrier drainage layer geotextile second one gravel bituminous film modified mineral sealing sandy gravel loamy soil used construction embankment cut four lysimeters soils spiked low contamination test efficiency technical safeguards percolate water lysimeters well road runoff value electrical conductivity concentrations sulphate chloride analyzed two week composite samples since july amount road runoff lysimeter runoff percolating water electrical conductivity measured continuously noted measures taken testing period order solve imperfections test set measures affected observations presented results show unfiltered road runoff shows considerable concentrations also elevated concentrations expected former experience literature embankment types lead strong retention two substances however elevated concentrations found percolating water times high chloride concentrations originating deicing salt furthermore shown average contaminant leaching lysimeter relatively small measurement period changes concentrations parameters seem induced mainly high chloride content infiltrating road runoff time occurrence changes effluent well temporal variations depend also soil type soil technical safeguards additionally seems soil type stronger influence percolation process compared different technical safeguards possible reasons discussed published elsevier
school professionals work students autism spectrum disorder asd play significant role academic experiences students evidence suggests teachers students asd experience high risk burnout research begun examine factors ameliorate prevent teacher burnout including teacher training teacher self efficacy teachers beliefs regarding abilities bring positive outcomes students present study examined variables associated self efficacy school professionals working students asd including knowledge asd prior experience working students asd prior training asd evidence based practices second goal present study investigate impact training asd evidence based practices school professionals knowledge self efficacy related working students asd particular participants received training prevent teach reinforce model results present study suggested importance training school professionals self efficacy highlighting need continued efforts provide quality training individuals work students asd
first five years parenting critical children development parents known respond best interventions partnership based approach yet child family health nurses cfhns report tension employing expertise maintaining partnership relationship article identifies ways cfhns skilfully use professional expertise underpinned helping qualities interpersonal skills assist families build confidence capacity thus buffer threats parent child well reports australian ethnographic study services families young children fifty two interactions observed cfhns families day stay home visiting services sydney new model presented based four partnership activities fluid movement show cfhns use expertise identify strengths foster resilience families longer term without undermining principles partnership
loss function mutations progranulin grn secreted glycoprotein expressed neurons microglia common autosomal dominant cause frontotemporal dementia neurodegenerative disease commonly characterized disrupted social emotional behaviour grn mutations thought cause frontotemporal dementia progranulin haploinsufficiency therefore boosting progranulin expression intact allele rational treatment strategy however approach tested animal model frontotemporal dementia unclear boosting progranulin could correct pre existing deficits show adeno associated virus driven expression progranulin medial prefrontal cortex reverses social dominance deficits grn mice animal model frontotemporal dementia due grn mutations adeno associated virus progranulin also corrected lysosomal abnormalities grn mice adeno associated virus progranulin vector transduced neurons suggesting restoring neuronal progranulin sufficient correct deficits grn mice test role neuronal progranulin development frontotemporal dementia related deficits generated two neuronal progranulin deficient mouse lines using camkii cre nestin cre measuring progranulin levels lines indicated brain progranulin derived neurons neuronal progranulin deficient lines developed social dominance deficits similar global grn mice showing neuronal progranulin deficiency sufficient disrupt social behaviour data support concept progranulin boosting therapies frontotemporal dementia highlight important role neuron derived progranulin maintaining normal social function
recent work introduced social dynamic models people stress related processes including amelioration stress symptoms support others effects support may direct depending level support buffering depending product level support level stress focus nonlinear buffering term use model involving three variables control parameters including stress perceived individual physical psychological symptoms currently active social support model quantified set three nonlinear differential equations governing stationary state stability temporal evolution sometimes oscillatory variable affects others chaos may appear periodic forcing environmental stress parameter explore model carefully strength amplitude forcing important psychological parameter relating self kindling stress response varied three significant observations made exist many complex orderly regions periodicity chaos nested regions increasing number peaks per cycle may cascade chaos areas one state period oscillation chaos coexist parameters one reached depends initial conditions elsevier rights reserved
nanotechnology used frequently marketing skin care goods whereas word sounds belongs robotics science fiction rapidly becoming common medicine skin care people actually recognize technology benefits possible implications use determined outline type nanotechnology significant cosmetics skin care health products use nanoparticles bucky balls known manufacturing particular kind nanoparticles touted next generation liposomes nanoliposomes one recognized names nanoparticles used skin care cosmetic products also familiar term liposome connection two perhaps best way clarify nanoliposomes article techniques production reviewed common methods nanoliposome preparation discussed
aimsto test relationship early cognitive ability major changes smoking habits across adulthood test whether educational attainment mediates associations designprospective observational study examine link cognitive ability smoking initiation relapse cessation multiple time points throughout adulthood pooled analysis two cohorts settinggreat britain participantsa total participants two british cohorts british cohort study bcs national child development study ncds participants female smokers smokers reported never smoking measurementscognitive ability assessed age years bcs years ncds outcomes smoking initiation relapse cessation derived changes smoking status observed across five time points ages bcs six time points ages ncds educational attainment examined mediating variable controls age gender social class self control psychological distress parental smoking study indicator bcs ncds findingsin adjusted regression models standard deviation increase cognitive ability predicted percentage point reduced probability smoking percentage point higher probability smoking cessation throughout adulthood change likelihood smoking relapse significantly differences educational attainment explained approximately half association childhood cognitive ability smoking initiation cessation conclusionslower cognitive ability measured childhood smoking initiated appears predict higher likelihood taking smoking lower likelihood quitting adulthood educational attainment appears mediate effect children higher cognitive ability tend become highly educated adults turn predicts lower rates smoking initiation increased rates smoking cessation
understanding biology spontaneous clearance hepatitis virus hcv infection could lead improved strategies prevent sequelae associated chronic hcv infection chronic infections hepatitis virus common china factors associated spontaneous clearance hcv adequately studied evaluated spontaneous clearance hcv among drug users hcv seropositive blood donors guangzhou china among participants infected hepatitis virus hbv drug users blood donors cleared hcv infection without antiviral therapy compared drug users blood donors mono infected single virus proportion subjects cleared hcv infection significantly greater infected subjects whose serum hbv dna greater lower levels multiple logistic regression analysis found female gender ilb genotype hbv infection blood donors drug users associated increased spontaneous clearance hcv infection although acute hcv infections common china incidence chronic hcv may reduced among high prevalence chronic hbv ilb genotypes associated spontaneous clearance hcv chinese populations
purpose review globally majority need mental health care worldwide lack access high quality mental health services stigma human resource shortages fragmented service delivery models lack research capacity implementation policy change contribute current mental health treatment gap review describe health systems low middle income countries lmics addressing mental health gap identify challenges priority areas future research recent findings common mental disorders responsible largest proportion global burden disease yet sound evidence disorders well severe mental disorders successfully treated using evidence based interventions delivered trained lay health workers low resource community primary care settings stigma barrier service uptake prevention though necessary address mental health gap solidified research programmatic focus research practice implementation studies required inform policies scale services summary four priority areas identified focused attention diminish mental health treatment gap improve access high quality mental health services globally diminishing pervasive stigma building mental health system treatment research capacity implementing prevention programs decrease incidence mental disorders establishing sustainable scale public health systems improve access mental health treatment using evidence based interventions
icariin main active flavonoid glucoside isolated herba epimedii demonstrated potential alternative therapy prevent postmenopausal osteoporosis icariin also shown regulate proliferation osteogenic differentiation rat bone marrow stromal cells rbmscs however detailed molecular mechanism icariin remained largely unknown besides investigation focused relevance icariin regulation rat adipose derived stem cells rascs proliferation osteogenic differentiation present study detected icariin promotes proliferation osteogenic differentiation rascs concentration range optimal concentration found icariin significantly increased active rhoa protein expression rock substrate molecule mypt expression rascs rhoa inhibitor treatment abrogated increased proliferation osteogenic differentiation rascs induced icariin interestingly also found abrogated activation taz induced icariin depletion taz sirna transfection significantly blocked icariin promoted proliferation osteogenic differentiation rascs however icariin induced active rhoa protein expression affected taz specific sirna transfection suggesting rhoa lies upstream taz taken together data indicate icariin promotes proliferation osteogenic differentiation rascs activating rhoa taz signaling pathway elsevier masson sas rights reserved
unphysical results presented article thermodynamical properties rbcs liquid binary alloys discussed concluded paper pseudo scientific misleads readers regarding thermodynamics binary mixtures
background great east japan earthquake inflicted severe damage pacific coastal areas northeast japan although possible health impacts aged handicapped populations highlighted little known serious disaster affected preschool children health conducted nationwide nursery school survey investigate preschool children physical development health status throughout disaster methods survey conducted september december mailed three kinds questionnaires nursery schools prefectures japan questionnaire addressed nursery school information questionnaires addressed individuals data targets children born april april experience disaster preschool days children born april april experienced disaster preschool days questionnaire inquired disaster experiences anthropometric measurements presence diseases results total nursery schools prefectures participated survey established two nationwide retrospective cohorts preschool children children born april april children born april april among latter cohort reported specific personal experiences disaster conclusions large dataset expect yield comprehensive study results preschool children physical development health status throughout disaster
prospective studies showed low serum testosterone concentrations associated various cardiometabolic risk factors mortality however causal nature associations controversial studied men aged years serum testosterone concentrations genotyping data longitudinal population based study health pomerania testosterone concentrations cross sectionally associated cardiometabolic risk factors including anthropometric lipid blood pressure glycaemic parameters prospectively cause mortality deaths year follow overcome problems residual confounding reverse causation regression dilution bias investigated testosterone outcome associations used two stage least square regression models previously identified polymorphisms shbg gene chromosome multiple genetic instruments instrumental variable approach also known mendelian randomization standard regression analyses testosterone robustly associated wide range cardiometabolic risk factors subsequent analyses significant associations observed similarly prospective analyses showed consistent association low testosterone concentrations increased cause mortality risk apparent subsequent analyses present mendelian randomization analyses detect evidence causal associations testosterone concentrations cardiometabolic risk factors mortality suggesting previously reported associations might largely result residual confounding reverse causation although testosterone assessment might improve risk prediction implementation testosterone replacement therapy requires evidence direct effect cardiometabolic outcomes double blinded randomized controlled trials large scale mendelian randomization meta analyses
process automation systems widely known crucial element processing plants power plants chemical petrochemical oil refining food automotive many processes industry vast complex said controlled handful major players worldwide computer control systems control engineering methods heart automatically controlled processes motivated practical success modern control engineering methods many industrial process consumer electronics products increasing amount work development new methods based new robust adaptive methods numerical optimization techniques soft computing strategies microcomputers decentralized control structure hardware embedded controllers realization paper presents current state development currently widely used control methods structures applications different types automated processes objective paper survey compare performance conventional controllers several selected advanced controllers regard advantages drawbacks industrial applications
mammalian circadian timing system consists master pacemaker suprachiasmatic nucleus scn subordinate clocks disseminate time information various central peripheral tissues function scn circadian rhythm regulation extensively studied still limited understanding peripheral tissue clock function contributes regulation physiological processes adrenal gland plays special role context adrenal hormones show strong circadian secretion rhythms affecting downstream physiological processes time shown affect clock gene expression various tissues thus mediating systemic entrainment external zeitgebers promoting internal circadian alignment review discuss function circadian clocks adrenal gland reset scn may relay time day information tissues focusing glucocorticoids conclude outlining impact adrenal rhythm disruption neuropsychiatric metabolic immune malignant disorders
although homosexuality evoke disgust extent disgust influences judgments transgressions committed homosexuals remains unclear address knowledge gap participants high hhd low lhd homosexual disgust provided disgust immorality ratings offenses committed homosexuals heterosexuals present study also examined extent judgments violations social mores homosexuals heterosexuals differed function purity violation consistent predictions hhd participants significantly higher disgust immorality ratings lhd participants violations committed homosexuals however two groups differ ratings violations committed heterosexuals findings also revealed difference violations committed homosexuals heterosexuals disgust greater violation contain impurity versus impurity present however pattern findings observed differences ratings immorality lastly pathogen sexual moral disgust mediated association moral purity ratings violations committed homosexuals mediated effect observed ratings violations committed heterosexuals implications findings better understating moral perceptions homosexuality discussed elsevier ltd rights reserved
purpose present study investigate epidemiology high heel related injuries among nationally representative population women united states analyze demographic differences within group data used present study collected consumer product safety commission national electronic injury surveillance system total injuries representing estimated high heel related injuries treated emergency departments within united states overall rate high heel related injuries study per females confidence interval injury rate greatest young adult females greatest rates observed aged years per females aged years per females results present study suggest high heel related injuries nearly doubled year period injuries high heels differential body region injuries occurring sprains strains foot ankle although high heels might stylish health standpoint could worthwhile females interested wearing high heels understand risks wearing high heeled shoes potential harm precarious activities high heeled shoes cause results present study used development prospective cohort study investigate risk injury high heeled shoes accounting exposure time studying differences demographics age race american college foot ankle surgeons rights reserved
today enterprise world information business entities customer patient name address social security number often present relational databases well content repositories information business entities generally well protected databases well defined fine grained access control however current document retrieval systems provide user specific fine grained redaction documents prevent leakage information business entities documents leaving companies two choices either providing complete access document risking potential information leakage prohibiting access document altogether accepting potentially negative impact business processes paper present zorro add document retrieval systems dynamically redact sensitive information business entities referenced document based access control defined entities zorro exploits database systems fine grained label based access control mechanism identify redact sensitive information unstructured text based access privileges user viewing make fly redaction feasible zorro exploits concept safety combination lucene based indexing scoring demonstrate efficiency effectiveness zorro detailed experimental study
atopic dermatitis common chronic inflammatory skin disease driven terminal keratinocyte differentiation defects strong type immune responses contrast chronic plaque type psoriasis understood much heterogeneous disease additional activation cytokine pathways depending subtype disease review discuss current understanding immune map patients early onset chronic disease clinical studies broad targeted therapeutics helped elucidate contribution various immune axes disease phenotype importantly immune activation extends well beyond lesional nonlesional skin blood component harbor specific inflammatory changes reason future therapeutics need focus systemic treatment approach especially patients moderate severe disease
background even today scenario post menopausal women blindly treated hormone replacement therapy alleviate symptoms without proper judgment side effects study carried evaluate role phytoestrogens therapeutic alternative hormone replacement therapy post menopausal women materials methods prospective study carried department obstetrics gynaecology rama medical collage hospital research centre mandhana kanpur evaluate role phytoestrogens therapeutic alternative hormone replacement therapy post menopausal women symptomatic post menopausal women natural surgical menopause symptoms related menopausal syndrome selected selected post menopausal women administered regular dose phytoestrogen namely soy isoflavones period months cases followed severity symptoms studied regularly time months results cases regular treatment observed cases cases took irregular treatment cases stopped treatment cases failed follow regular cases showed substantial improvement symptoms like vasomotor symptoms insomnia depression lethargy etc maximum benefit found hot flushes insomnia depression lethargy vaginal dryness conclusion though results study highly encouraging comparable earlier studies significant role phytoestrogen hrt fully established repeated study larger count patients increased duration therapy prove superior role phytoestrogen hrt without side effects
nowadays detection trace concentration gases still challenging portable sensors especially low cost easily operated metal oxide semiconductor mox gas sensors paper widely applicable amplification circuit designed fabricated evidently enhance signal mox sensors adding field effect transistor fet conventional circuits optimizing fet parameters loading resistance amplification circuit enables commercial figaro tgs toluene sensors response effectively highest permissive limit ppm toluene indoor air cars detection limit similar ppm furthermore circuit also make commercial hanwei acetone sensors ethanol sensors response ppm acetone breath diabetes ppm ethanol fast effectively drinker driver screening mechanism investigated gate voltage induced resistance change fet highest theoretically estimated experimentally measured magnification factor fet amplifier effectively enable ppm level commercial mox sensors response sub ppm level gases promising mox gas sensor integration also kind resistive sensors
particularly claim disputes concerning delay construction time caused client based vob consistent opinion concerning consideration appropriate amount general costs claims mainly issue quite complex legal cost theoretical construction business management characteristics considered explaining essential construction business management characteristics well main legal construction management principles paper two new methods estimating general costs claim requests presented manufacturing costs construction time method capacity utilization method successive second paper new methods validated compared two main already practice existing methods concerning cost evaluation general costs result contradiction current practice general costs considered claims without additional construction time entitlement according clause vob contrast additional construction time entitlement according clause vob lead general costs depend relation additional contractual construction time original construction time consideration correction factor
humerus fossorial moles highly derived anatomy reflecting ecological specialization animals digging short broad enlarged muscle attachment sites pronounced articulations compared non fossorial sister taxa mammals condyles rotated opposite directions resulting torsion unique among eutherian mammals development exceptional bone studied embryonic stages fossorial iberian mole talpa occidentalis mesenchymal condensation incipient ossification based histological serial sections using reconstruction methods comparison embryonic stages semi fossorial japanese shrew mole urotrichus talpoides well sister taxon moles terrestrial north american least shrew cryptotis parva studied results show humerus talpa already shows derived anatomy broadened muscle attachment sites distinct articulations early cartilaginous stages ossification started mid diaphyseal region torsion takes place simultaneously medial rotation forelimbs supracondylar foramen closed studied talpa embryos patent cryptotis urotrichus example developmental penetrance suggesting variation adult elements found early stages well
multilevel inverters generate high level voltage high quality low harmonic distortion unique properties increased applications renewable energy sources however inverters require several passive components complex pulse width modulation pwm control method besides suffer voltage balancing problems work new inverter proposed generates seven level voltage one source reduced number switches exhibit voltage balancing problem proposed inverter without extra boost circuit able increase input voltage voltage stress switches proposed inverter study variable amplitude phase disposition pwm control method compatible proposed inverter developed moreover extended structure proposed inverter new algorithm generating odd even voltage levels proposed validate performance inverter prototype built tested also performance modelled using pscad emtdc software package good agreement achieved experimental results simulations
one requirements achieving faster cmos electronics mitigate unacceptably large chip areas required steer heat away recently toward critical nodes state art devices thermal guiding structures efficiently direct heat meta materials engineering however key aspects behavior systems fully understood demonstrate control thermal diffusion properties structures using nanometer scale cmos integrable graphene silica stacked materials finite element methods simulations shown possible implement novel controllable thermally based boolean logic spike timing dependent plasticity operations advanced neuromorphic computing applications using thermal guide architectures
supply water rural populations developing countries continues present enormous problems particularly arsenic contamination groundwater exists significant parts bangladesh response improvements sustainability water supplies feasible use combination water sources wherein rainwater harvesting employed portion year potentially reduce duration year arsenic contaminated groundwater utilized demonstrated rainwater cistern volume jessore district area bangladesh provide rainwater periods averaging days year allows groundwater arsenic used water supply remainder year dual supply approach provides body burden equivalent interim drinking water guideline arsenic concentration days year assuming water consumption rate cap day family five rainwater collection area water use rate cap day cistern provide water days year however although insufficient supply water meet body burden equivalent guideline results provided also different rooftop areas sizes cisterns alternative arsenic guidelines world health organization bangladeshi findings provide useful guidelines supply options meet sustainability targets water supply however also demonstrate use cisterns assist meeting target arsenic body burden arsenic contamination groundwater high
low energy noise switched capacitor sensor interface resistive bridge sensor presented amplifier achieves low power metric two operating modes using operation phase dependent biasing compensation scheme amp design novel amp works high bandwidth high power mode sample bridge signal twice low bandwidth low power mode measurement interval reduce power amplifier system level level shift design adopted regarding offset calibration capacitor divider based trimming scheme implemented generate mid point output voltage constraint feedback capacitor size implemented cmos interface together regulator voltage reference trimming circuit occupies area first test setup utilizing half wheatstone bridge proposed amplifier consumes regulated supply khz system clock measured signal noise ratio snr circuit second test setup using commercial sensor kpa sensitivity interface demonstrated sensing function sensitivity kpa finally compared representative prior arts work achieved best energy noise figure merit identical fractional resistance change
elaboration smart materials optical fiber sensors embedded several dissimilar layers capable monitoring various system parameters inside layered structure without damaging host structure work mainly concentrates thermal elaboration process used embed optical fibers ceramic coating layers characterization new mechanical holder first proposed order maintain optical fiber thermal spray process protect strong atmospheric turbulence caused heat flux wire flame thermal spray particles propelled substrate temperature degrees chosen elaboration process favorable elaboration conditions evaluated microscopic characteristics surface cross section embedding structure evaluated mechanical adhesion strength embedded optical fiber measured discussed results show optical fiber remains undamaged thermal spray process keeps perfect adhesion ceramic coating making former competitive method elaborate embedded hybrid structure
ability region provide clean water relates many aspects physical economic elements use natural social indicators evaluate feature measure ability region provide clean water meet needs population water demand supply index wdsi defined ratio amount water demand water supply obviously index region suffering water scarcity water demand includes industrial water agricultural water domestic water water supply consists surface water groundwater clean water evaluate model select six countries spreading five water stress indicator interval water scarcity map calculate wsdi apply cluster analysis divide countries five classes test result fits water stress indicator interval showed water scarcity map perfectly choose beijing investigation water heavily overloaded considering dynamic nature factors adopt supply demand balance theory predict development trend water supply demand separately according forecast water shortage beijing serious next years industrial water increase gradually sewage reuse rainwater harvesting project water desalination projects make great progress provide large proportion water supply future
paper addresses dynamical behaviors switching van der pol circuits investigating stability issues autonomous nonlinear dynamical systems firstly kind nonlinear dynamical systems piecewise switching autonomous nonlinear system used formulate class van der pol circuits composed least two alternative electrical sub circuits secondly based concept system stability sense lyapunov continuously positive definite functions paper proposes two new necessary sufficient conditions stability asymptotic stability autonomous nonlinear systems thirdly based new stability results obtained paper present several criteria globally asymptotical stability local instability unique zero equilibrium kind electrical circuits meanwhile existence uniqueness stable limit cycle also given switching van der pol circuit novel results obtained paper show switching actions involved van der pol circuits may vanish classical nonlinear dynamical phenomena relaxation oscillations finally numerical simulations several nonlinear systems switching van der pol circuit illustrate effectiveness practicality new results
janus kinase jak located chromosome band jakvf common mutation philadelphia chromosome negative myeloproliferative neoplasms phmpn however rearrangement jak rare event report case myeloproliferative neoplasm unclassifiable mpn bcr jak fusion confirmed molecular studies conventional chromosome analysis revealed fluorescence situ hybridization fish showed jak gene rearrangement interphase nuclei bcr jak fusion confirmed multiplex reverse transcriptase polymerase chain reaction pcr demonstrated two frame jak transcripts bcr exon juxtaposed jak exon exon respectively results together literature review reveal bcr jak fusions oncogenic genetic alterations associated myeloid lymphoid neoplasms frequently characterized eosinophilia patients bcr jak candidates jak inhibitor therapy given distinct clinical pathological characteristics believe hematological neoplasms harboring bcr jak included additional distinct entity current category myeloid lymphoid neoplasms eosinophilia abnormalities pdgfra pdgfrb fgfr testing jak fusion pursued neoplasms karyotypic abnormality
humans diagnosed alcohol use disorder sensitive painful stimuli withdrawal suggests excessive alcohol drinking worsens pain outcomes alcohol dependent rats exhibit increases nociceptive sensitivity withdrawal data animal models suggest brain melanocortin receptors mcrs mediate alcohol drinking nociception tested effect alcohol dependence thermal nociception rats ability acute alcohol mcr antagonists reverse hyperalgesia withdrawal alcohol dependent rats rats trained self administer operant alcohol tested baseline thermal nociception half rats made dependent alcohol rats cannulated lateral ventricle tested effects acute alcohol drinking acute fixed dose alcohol intra ventricular agouti related protein endogenous mcr antagonist intra ventricular synthetic mcr antagonist intra nasal hyperalgesia withdrawal alcohol dependent rats relative non dependent drinkers alcohol naive controls alcohol dependent rats exhibit thermal hyperalgesia abolished alcohol drinking bolus alcohol intra ventricular intra nasal mcr antagonists manipulations affect thermal nociception non dependent drinkers alcohol naive controls suggesting alcohol dependence produces neuroadaptations brain mcr systems results suggest brain mcr systems may effective therapeutic target reducing nociception alcohol dependent organism
development population policy health legislation result government need young healthy working military active population resulted education health workers including midwives legal regulation work increasing number training midwifery profession development profession conditions women giving birth pregnancy birth control gradually improved thus influenced birth rate mortality population natural growth example town brod savi one see time consuming controlled development midwifery profession region affected poor socio economic conditions poor climatic conditions presence border consequent large scale migration population important note foundations population policies observed midwifery profession enabled development coming period
objective objective test feasibility acceptability computerized tool smart choices designed enhance quality contraceptive counseling family planning clinics tool includes questionnaire completed patients summarized printout providers birth control guide patients explore learn various contraceptive methods study design family planning clinics conducted interviews women used smart choices computerized tool providers results smart choices integrated clinic flow well one clinic less well short waiting times patients generally enthusiastic smart choices including helpfulness preparing providers counseling session increasing knowledge contraceptive methods providers varied much used printout opinions usefulness felt usefulness limited overlapped clinic intake forms match concept counseling needs others felt provided valuable information collected intake forms honest information found smart choices helpful patients unsure method wanted conclusions smart choices feasible implement well received patients modifications needed increase provider enthusiasm tool implications smart choices tool requires refinement widespread dissemination elsevier inc rights reserved
aim study assess factors predicting experiences avoidance discrimination positive treatment people mental health problems telephone interviews carried australians aged reported mental health problem scored highly symptom screening questionnaire questions covered experiences avoidance discrimination positive treatment friends spouse family workplace educational institution others community well disclosure mental health problems avoidance discrimination positive treatment scores calculated counting number domains occurred predictors avoidance discrimination positive treatment modelled negative binomial regression analyses adjusting effects predictors multivariate analyses symptom severity diagnosis disorder commonly psychotic disorders eating disorders predicted experiences avoidance discrimination positive treatment disclosing mental health problem settings also associated higher rates avoidance discrimination also positive treatment disclosure mental health problems others may increases experiences discrimination may also increase experiences positive treatment findings help inform decision making people mental health problems disclosure particularly case severe low prevalence disorders
extreme hydrometeorological events flash floods caused considerable loss life damage infrastructure recent years flood events mediterranean region caused fatalities cost sic billion damage italy one worst affected countries distributed computing infrastructure hydro meteorology drihm project european initiative aiming providing open fully integrated escience environment predicting managing mitigating risks related extreme weather phenomena incorporating modeled observational data sources enables seamless access set computing resources objective providing collection services performing experiments numerical models meteorology hydrology hydraulics purpose article demonstrate flexible modeling architecture constructed using set standards including netcdf waterml file formats memory coupling openmi controlled vocabularies standard names iso metadata model map metadata adaptors portability gateway concept preparing numerical models standardized use hydraulic results including impact buildings hazards people given use cases severe fatal flash floods occurred genoa italy november october
order understand luminous efficiency visible wavelength infrared wavelength range generated hypervelocity impact natural dolomite plate experimental measurement light flash created hypervelocity impact natural dolomite plate performed visible wavelength range using optical transient pyrometer measurement system two stage light gas gun loading system different impact velocity projectile incident angles degrees degrees angle along target plane respectively based planck blackbody continuous radiation law visible wavelength range luminous efficiency extrapolate infrared wavelength range combining matlab computer programming calculated results luminous efficiency showed luminous efficiency light flash created hypervelocity impact natural dolomite plate infrared wavelength range approximately similar times visible wavelength range
review clinical studies psychiatric comorbidity short term long term abstinent treatment alcoholics staa ltaa tna tna ypically less severe alcoholism treated abstinent samples evidence less severe psychiatric disturbance lifetime psychiatric diagnoses norm staa ltaa tna individuals alcohol drug use disorders show greater antisocial personality disturbance show differences mood anxiety domains borderline personality disorder bpd symptoms studies show alcoholics achieve maintain abstinence face ongoing mood anxiety bpd problems contrast aspd ltaa essentially stop current antisocial behaviors seven domains antisocial behaviors believe ongoing antisocial behavior consistent maintaining abstinence ltaa modify antisocial behavior despite continued elevated social deviance proneness antisocial dispositionality abstinent individuals without lifetime psychiatric disorders tna show subdiagnostic threshold psychiatric symptoms abnormal psychological measures non alcoholic controls mood anxiety bpd antisocial domains summary studies show although ltaa achieved multi year abstinence still report significant psychological distress compared nac believe distress may negatively affect quality life suggests importance developing effective care models address comorbid mental health problems ltaa also show antisocial personality disorder symptoms decline levels seen normal controls excluding individuals research psychiatric diagnosis control subdiagnostic psychiatric differences alcoholics controls
overlapping community detection algorithm research one hot topics current social network analysis paper applied idea weighted label propagation overlapping community detection algorithm design propose weighted label propagation algorithm wlpa moreover order evaluate performance results various overlapping community detection algorithms put forward series evaluation criteria based error distribution curve overlapping vertices experiment results show algorithm faster speed better community detection results evaluation criteria line inherent characteristics social network overlapping community structure
synthesis novel class piperazine benzamide reverse amides targeting human beta adrenergic receptor treatment overactive bladder oab described sar studies directed towards maintaining well established potency selectivities improving overall pharmacokinetic profile reverse amide class evaluated results consequences associated functional activity norepinephrine transporter net also discussed elsevier ltd rights reserved
stereotypical media coverage persons physical disabilities pwds repeatedly criticized biased depictions pwds negatively affect nondisabled recipients attitudinal evaluations pwds however remains unclear superordinate context disability frequently used journalists depict pwds media contexts sports affect recipients attitudes toward pwds portrayed media potential context effects analyzed help two experiments subjects design study nondisabled participants randomly assigned four groups context manipulated subliminally exposing participants different textual primes disability sports politics prime control group participants subsequently evaluated visually depicted pwd arm amputation study nondisabled participants randomly assigned three groups read illustrated print article picture study used context manipulated help specific news cues disability sports politics rest article remained unchanged studies context disability significantly lowered participants evaluations pwd contrast sports studies systematically positive impact participants attitudes toward pwd furthermore general acceptance pwds society perceived positive sports cues study implications media coverage pwds discussed
bending problem euler bernoulli discontinuous beams classic topic mechanics paper stepped beams internal springs addressed based theory generalized functions shown context closed form expression may given green functions due point forces based beam response arbitrary loads set boundary conditions proposed solution method may presented regular course mechanics solids strength materials undergraduate students require advanced knowledge theory generalized functions knowledge basic concepts generally presented courses instance dynamics structures hoped may help students address simple effective way many engineering applications involving discontinuous beams
brain single photon emission computerized tomography spect particular perfusion agents neuroreceptor imaging radiopharmaceuticals rapidly becoming clinical tool many neurologic psychiatric conditions imaging modality used diagnosis prognosis assessment evaluation response therapy risk stratification detection benign malignant viable tissue choice medical surgical therapy present institutional experience area formatting pictorial review brain perfusion spect types different neurologic psychiatric diseases dementia epilepsy cerebral palsy head injury brain tumor herpes encephalitis hypoxic brain damage vacuities depression carbon monoxide poisoning cocaine abuse demanding procedure far need trained experienced physicians personnel well advanced equipment concerned however extraordinary useful clinical information achieved technology outweighs existing challenge routine use procedure unfortunately underutilized many countries including encouraged
chitinases varied sized proteins ability degrade chitin present huge range organisms like fungi yeasts arthropods humans etc getting increased attention due biocontrol properties silico analysis sheds light extensive properties plant protein paper particular antifungal protein chitinase sourced sechium edule east khasi hills meghalaya characterized using array bioinformatics tools modelled protein showed conserved domains characteristic glycosyl hydrolase family superfamily likewise part conserved domain area fits xylanase inhibitor xip class iii plant chitinases example concanavalin hevamine area modelled wild type protein exhibited secondary characteristics comprising helix sheets turns displaying aliphatic index instability index inferring upon fact protein relatively unstable without appropriate environment paper functions first attempt portray molecular dynamics simulation chitinase sechium edule reinforced modelling thorough characteristic analysis protein employing parameters like ramachandran plot chou fasman secondary structure prediction protparam etc approaches like protein engineering activity analysis suggested elsevier rights reserved
purpose paper compare structural responses obtained stochastic analysis suspension bridge subjected uniform partially correlated seismic ground motions using different spatial correlation functions commonly used earthquake engineering spatial correlation function employed study consists term characterizes loss coherency account spatial variability ground motions widely used four loss coherency models literature taken account study models characteristics intended determine sensitivity suspension bridge due losses coherency models represent spatial variability ground motions bosporus suspension bridge connects europe asia istanbul selected numerical example bridge steel towers flexible inclined hangers steel box deck main span side spans european asian sides respectively ground motion filtered white noise model considered applied vertical direction intensity parameter model obtained using component pacoima dam record san fernando earthquake analytically simple model called filtered white noise ground motion model chosen represent earthquake ground motion compared uniform ground motion case results obtained spatial variability models partial correlation outline necessity include spatial variability ground motions stochastic dynamic analysis suspension bridges observed largest response values obtained model proposed harichandran vanmarcke model proposed uscinski produces smallest responses among considered partially correlated ground motion models response values obtained uniform ground motion case usually smaller responses obtained partially correlated ground motion cases response values flexible parts bridge totally dominated dynamic component pseudo static component also significant contributions response values rigid parts bridge results also show consistency spatial variability models different characteristics considered study
alcohol use disorder aud complex brain disorder array persistent behavioral neurochemical manifestations genetic environmental factors known contribute development aud recent studies alcohol exposure subsequent changes gene expression suggest importance epigenetic mechanisms particular histone modifications dna methylation emerged important regulators gene expression associated phenotypes aud given therapeutic potential epigenetic targets review aims summarize role epigenetic regulation current understanding aud evaluating known epigenetic signatures brain regions critical addictive behaviors animal human studies throughout various stages aud specifically effects acute chronic alcohol exposure tolerance postexposure withdrawal epigenetically induced changes gene expression synaptic plasticity within key brain regions associated behavioral phenotypes discussed understanding contribution epigenetic regulation crucial signaling pathways may prove vital future development novel biomarkers treatment agents ameliorating preventing aud
paper based pareto dominant theory gradient method proposed kind dominate gradient strategy dominate gradient intervention rule local search solving algorithm design order solve practical problems analysis discussion two dimensional functions detail defined situations real superior real inferior false inferior false superior analyzing function instance elaborated situations dominate gradient definition paper extend two dimensional functions multi dimensional functions order put forward new angle seeking gradient direction optimizing local search worth generalized kept researches solving practical problems
extranodal cell lymphoma enktl nasal type rare type non hodgkin lymphoma commonly seen east asian countries associated epstein barr virus infection retrospective study describe nine cases enktl nasal type diagnosed treated center period years cases analyzed retrospectively clinical presentation age sex site involvement immunophenotype treatment response toxicity profile sino nasal symptoms blocked nose headache epistaxis regurgitation common presenting complaints almost cases referred bhutan necrosis angiocentricity commonest histological features depending stage disease patient initially treated chemotherapy smile chop radiotherapy ifrt describe experience management enktl observe bhutan could endemic region rare tumour
root system analysis complex task often performed fully automated image analysis pipelines however outcome rarely verified ground truth data might lead underestimated biases used root model archisimple create large diverse library ground truth root system images image three levels noise created library used evaluate accuracy usefulness several image descriptors classically used root image analysis softwares analysis highlighted accuracy different traits strongly dependent quality images type size complexity root systems analyzed study also demonstrated machine learning algorithms trained synthetic library improve estimation several root system traits overall analysis call caution using automatic root image analysis tools thorough calibration performed dataset interest unexpected errors might arise especially large complex root images facilitate calibration image library different codes used study made available community
tumors derive single cell clone consist heterogeneous cell subpopulations diverse features functions limited number subclones selective advantage initiate tumors inoculated immunocompromised mice called cancer initiating cells cics cics isolated bulk tumors basis characteristics high reagent efflux degradation reactive oxygen species aldehyde dehydrogenase aldh activity normal conditions new cics produced existing cics rather non cics however stress conditions non cics occasionally produce cics phenomenon known plasticity dynamic exchange cics non cics may enable tumors survive unfavorable conditions cics located small portion tumors suggests microenvironmental factors induce inhibit cic phenotype might regulated intercellular signaling tumor cells review describes isolation cics tumor cell populations microenvironmental factors regulate cic phenotypes uterine cancer lymphoma
pediatric migraine followed frequent episodes dizziness vertigo tension type headaches children migraine show high sensitivity light noise also susceptible vestibular stimuli resulting vertigo dizziness previous studies found vertigo common among patients migraine vestibular migraine benign paroxysmal vertigo childhood identified common causes vertigo children without ear disease benign paroxysmal vertigo childhood also thought precursor later episodes migraine term vestibular migraine included part appendix international classification headache disorders edition beta version increasing number studies shown positive relationship migraine vertigo however vertigo easily identified parents pediatricians young children unable explain vertigo migraine related symptoms also applicable specialists pediatric neurologists otolaryngologists often know exact definition vertigo patients make correct differential diagnosis consequently inadequate evaluation treatment patients lead high socioeconomic cost review article discussing vertigo pediatric migraine help medical doctors effectively examine accurately diagnose promptly treat young children suffering migraine vertigo
studies casual sexual relationships experiences csres quantitative focus characteristics individuals experience increase qualitative research csres revealed new insights experienced among young adults synthesize qualitative knowledge csres experienced qualitative metasynthesis carried using studies published june yielding seven conceptual categories opportunities choices regarding csres organized according biographical context socioenvironmental context peer norms expectations csres related lack communication emotional sexual commitment accountability implicit rules allowed maintaining boundaries sex emotion thus csres satisfy various needs related sex intimacy sex csres reported pleasure centred accessible improved experienced association intimacy however intimacy gender roles interfered condom use sexual double standard gender roles limited women agency enjoyment sex expectations lack intimacy communication conflicted developing unrequited feelings resulting self blame attempts suppress emotions partners may hard time defining relationship time csres involved developing friendships romance ruining friendships results indicate clash expectations rules experiences csres lack symbolic markers meaning status csres develop seen consequence complexity relationships
culminating experience abet accredited undergraduate engineering programs capstone design courses might seem ideal setting fine tuning graduating seniors professional communication skills prior entering workplace capstone courses however involve team deliverables including written project report ensuring equal opportunity writing skills advancement assessment course participants difficult mechanical industrial manufacturing engineering mime capstone design course oregon state university incorporating individual writing experience necessitated status designated writing intensive course mime majors despite large size typically students course must satisfy associated university wide requirements including specification individual writing accounts least students final course grade meeting requirement involves three interwoven course components iteratively developed project report team members assigned specific authorial editorial roles involves formative assessment revision cycles metacognitive element involving reflective self assessment individual goal setting variety infrastructural support resources tools facilitate production assessment student writing article describes mime approach case study incorporating individual writing capstone design authors recognize solution devised response local opportunities constraints shelf adoption engineering institutions may neither appropriate viable information offered solely spirit showing effort possible invite wider cross institutional conversation topic
background number anticoagulated trauma patients increasing trauma patients warfarin found poor outcomes particularly intracranial hemorrhage ich however effect novel oral anticoagulants noas trauma outcomes unknown hypothesized patients noas would higher rates ich ich progression death compared patients traditional anticoagulant antiplatelet agents methods prospective observational trial across trauma centers inclusion criteria trauma patient admitted aspirin clopidogrel warfarin dabigatran rivaroxaban apixaban demographic data admission vital signs mechanism injury injury severity scores laboratory values interventions collected outcomes included ich progression ich death results total patients enrolled july june mean age years female non hispanic white least one comorbidity reported patients blunt trauma accounted patients median injury severity score interquartile range patients antiplatelet agents warfarin noas combination therapy subcutaneous agents patients taking noas higher risk ich univariate multivariate analysis incidence rate ratio confidence interval compared agents patients aspirin highest rate risk incidence rate ratio confidence interval ich progression ich occurred patients different medication groups study mortality significantly different groups univariate multivariate analysis conclusion patients noas higher risk ich ich progression death level evidence prognostic epidemiologic study level iii
micromagnetic materials characterization requires sensors essentially consist two critical elements electromagnet introduces well defined magnetic field material sensor system detects material response applied magnetic field devices developed fraunhofer izfp obtain multiparametric magnetic fingerprint sensors means several methods magnetic fingerprints calibration samples used input pattern recognition regression analysis thus allowing prediction mechanical technological material characteristics hardness yield strength etc residual stress approach called micromagnetic multiparameter microstructure stress analysis long term stability reproducibility sensor device characteristics crucial reliability measured results therefore measuring hardware follow minimalistic approach paper propose way simplifying measuring hardware multiple use sensor elements reducing analog signal processing chain transferring signal processing tasks
using online comments posted news stories context research used two experiments assess influence online comments people emotions well perceptions others emotions study showed people perceived uncivil disagreement comments posted news stories greater effect negative emotions civil disagreement comments addition found people perceived uncivil comments greater effect negative emotions others compared self suggesting support emotional third person perception tpp study showed people perceived agreement comments greater effect positive emotions uncivil disagreement comments findings also showed people perceived agreement comments equal effect positive emotions self compared others supports emotional first person perception fpp elsevier ltd rights reserved
study new voltage mode notch filter based current differencing transconductance amplifier cdta recently common used active building block analog signal processing applications presented proposed filter performance evaluated pspice simulation mosis cmos model parameters used cmos based cdta simulation results show proposed filter high performance terms working low high frequencies seen simulation results verified theory also sensitivities passive circuit components shown low
recognition facial affect studied extensively adults without traumatic brain injury tbi mostly asking examinees match basic emotion words isolated faces method may capture affect labelling everyday life faces context choices open ended examine effects context response format asked undergraduate students label emotions shown faces either isolation natural visual scenes responses categorised representing basic emotions social emotions cognitive state terms appraisals used students responses create scoring system applied prospectively five men tbi groups responses neither basic emotion words synonyms significant difference response types faces alone scenes adults tbi used labels seen students responses talked overall often gave multiple labels one photo results suggest benefits moving beyond forced choice tests faces isolation fully characterise affect recognition adults without tbi
background large numbers cells observed atopic dermatitis skin monocytes patients showed increased prostaglandin production however little known expression substance receptor nkr blood leukocytes patients objective explore expression nkr leukocytes influence allergens nkr expression methods expression levels nkr patients examined flow cytometry elisa mouse model results plasma level fold higher patients subjects percentage expression population mean fluorescence intensity mfi expression elevated cells blood patients however nkr population mfi nkr expression cells enhanced blood patients allergens aswe hdme ppe failed regulate expression cells however allergens aswe hdme enhanced nkr expression blood leukocytes regardless subjects ova sensitized mice showed elevated proportion mfi expressing cells blood agrees expression situation human blood injection mouse skin regulate nkr expression monocytes conclusions elevated plasma level regulated expression nkr indicate nkr complex important development therefore nkr antagonist blocker agents may help treat patients
previous research mostly defines benefits work absence unemployment negative outcomes benefits employers increased productivity study uses mixed methods investigate ways work enhance well worker two hundred two participants rural area participated semi structured qualitative interviews quantitative surveys participants qualitative discussions work interviews coded grounded theory majority participants mentioned work least interview focused prominent moments life stories work mentions positive two main themes encompassing protective benefits work arose self oriented benefits oriented benefits main theme divided three subthemes self oriented subthemes autonomy personal development empowerment oriented subthemes providing dependents generativity helping others participants spoke benefits enhances well happiness empowerment subtheme positively correlated workplace integration negatively correlated financial strain study uncovered protective benefits work addressed previous scholarship qualitative data provided flexibility explore work related domains quantitative scales currently exist work one main activities adults study psychological benefits work improve understanding adult well happiness
background rugby union high rate injury increased use protective equipment may help mitigate injuries study investigated injury prevention effectiveness protective equipment used rugby union methods cohort rugby players dunedin new zealand followed weekly club season assess protective equipment use participation rugby injury outcomes generalized poisson regression used model rate injury adjusting covariates level competition playing position injury history results use mouthguards appeared lower risk orofacial injury rate ratio confidence interval padded headgear tended prevent damage scalp ears support sleeves tended reduce risk sprains strains risk concussion lessened use padded headgear mouthguards evidence protective effects equipment item taping shinguards grease conclusions protective equipment used rugby union limited effectiveness preventing injuries results supportive however role mouthguards padded headgear preventing orofacial scalp injuries respectively support sleeves preventing sprains strains
interactive activation competition models iams account behavioral data implicit memory tasks also brain data start discussion standards developing evaluating cognitive models followed example demonstrations relate iam representations word length sequence frequency repetition orthographic neighborhood effects behavioral electrophysiological neuroimaging studies along ventral visual stream examine extent lexical competition account anterior cingulate cortex acc activation complex subsequent section presents associative read model arom extends scope iams introducing explicit memory semantic representations thereby account false memories familiarity recollection explaining memory signal variances greater studied non studied items since arom captures associative spreading across semantic long term memory also account different temporal lobe functions allows item level predictions left inferior frontal gyrus bold response finally use arom examine whether semantic cohesiveness account effects previously ascribed affective word features emotional valence show case positive negative valence elsevier ltd rights reserved
backgroundout pocket expenditures thought important barrier receipt cancer preventive services especially lower socioeconomic status ses affordable care act aca eliminated pocket expenditures recommended services including mammography colonoscopy objective study determine changes uptake mammography colonoscopy among fee service medicare beneficiaries aca implementation methodsusing medicare claims data study identified women years old older undergone mammography previous years men women years old older increased risk colorectal cancer undergone colonoscopy past years receipt procedures year period aca implementation implementation september also identified multivariate generalized estimating equation models used determine independent association county level quartile median income education receipt testing resultsfor mammography lower ses quartile associated less uptake post aca disparities smaller pre aca period addition mammography rates increased pre aca period post aca period ses quartiles colonoscopy pre post aca periods association uptake educational level extent income however appreciable changes colonoscopy ses implementation aca conclusionsthe removal pocket expenditures may overcome barrier receipt recommended preventive services colonoscopy procedural factors may remain deterrents cancer american cancer society although assumed elimination pocket expenses reduce socioeconomic disparities cancer screening little empirical evidence support contention using medicare data study shows affordable care act disparities decreased screening mammography colonoscopy
chapter proposed robust sensorless cascade control scheme permanent magnet synchronous motor pmsm drive discrete time variable structure control dtvsc considered rotor position speed obtained adaptive extended kalman filter aekf performance filter improved line adjustment input measurement noise covariances obtained suitably defined estimation algorithm proposed solution experimentally tested commercial pmsm drive equipped control system based floating point digital signal processor dsp
chemical instrumentation course usually analog signal conditioning data acquisition digital signal processing taught analog boards easy interconnection operational amplifiers available make introduction analog signal processing easier digitization process demonstrated microcontrollers cost microcontroller development boards decreased represent cost efficient platform clarify process data acquisition paper show construction meter development progresses characteristics operational amplifiers microcontrollers exposed hope making internal operation modern instrumentation transparent
pathogenesis parkinson disease closely associated aggregation alpha synuclein protein several familial mutants identified shown affect aggregation kinetics alpha synuclein distinct molecular mechanisms quantitative evaluation relative stabilities wild type mutant fibrils crucial understanding aggregation process land identifying key component steps work examined two topologically different alpha synuclein fibril structures either determined solid state nmr method modeled based solid state nmr data characterized conformational properties thermodynamic stabilities using molecular dynamics simulations show two fibril morphologies comparable size solvent exposure secondary structures similar molecule peptide binding modes different stabilities familial mutations significantly alter overall fibril structures shift relative stabilities distinct mutations display altered fibril conformational behavior suggesting different propagation preferences reminiscent cross seeding among prion strains tau deletion mutants simulations quantify hydrophobic electrostatic interactions well terminal dynamics may contribute divergent aggregation kinetics observed experimentally results indicate small molecule peptide inhibitors may share binding region providing molecular recognition independent fibril conformation
demonstrate circuits generate set integer partitions set objects rate one per clock partitions ways group elements set together extensively studied researchers algorithm design theory offer two versions hardware set partition generator first partitions produced lexicographical order response successive clock pulses second index input determines set partition produced circuits useful hardware implementation optimum distribution tasks processors show circuits integer partitions well circuits combinational large large delay however one easily pipeline produce one partition per clock period show analytical experimental time complexity results quantify efficiency designs example results show hardware set partition generator running mhz fpga produces partitions rate approximately times rate software implementation processor running ghz
photogrammetry remote sensing computer vision robotics topic major interest represented automatic analysis point cloud data task often relies use geometric features amongst particularly ones derived eigenvalues structure tensor three dimensionality features linearity planarity sphericity proven descriptive therefore commonly involved classification tasks although geometric features meanwhile considered standard little attention paid accuracy robustness paper hence focus influence discretization noise commonly used geometric features specifically investigate accuracy robustness eigenvalues structure tensor also features derived eigenvalues thereby provide analytical numerical considerations clearly reveal certain features susceptible discretization noise whereas others robust international society photogrammetry remote sensing inc isprs published elsevier rights reserved
across globe economic fluctuations taken toll organizations employees particularly sustained recessions surprisingly little research however directly investigated effects recessions employees goal current study investigate effects specific recession related stressors employee outcomes strain satisfaction investigated archival data set individuals collected part workplace employment relations study relations among recession related stressors strain job satisfaction variables found recession related stressors significantly related strain satisfaction specifically certain recession related stressors increased workload reorganization work strongly related strain satisfaction others results imply need greater attention stress management strategies aimed helping employees organizations cope human costs economic recessions copyright john wiley sons ltd
studies identified proliferation cigarette advertisements twitter investigate whether prevalence cigarette related advertising associated state tobacco regulations taking socio economic characteristics account collected cigarette related tweets july october twitter state regulations smoking prevalence provided campaign tobacco free kids program socio economic data provided american community survey number commercial tweets day high potential reach day prevalence commercial tweets varied significantly state higher prevalence cigarette advertising associated states better tobacco control impact lower youth smoking prevalence multivariate analysis state tobacco control impact significantly associated prevalence commercial tweets beta policies federal state levels needed regulate content commercial tweets mitigate negative effect social media advertisements
astrocyte mediated inflammation associated degenerative pathologies alzheimer parkinson diseases multiple sclerosis acute inflammation morphological metabolic changes astrocytes develop insult known reactive astroglia astrogliosis important response protect repair lesion astrocytes optimize metabolism produce lactate glutamate ketone bodies order provide energy neurons deprived nutrients upon insult firstly review basis inflammation morphological changes different cell population implicated reactive gliosis next discuss active metabolic pathways healthy astrocytes explain metabolic response astrocytes insult different pathologies metabolic alterations generate complications diseases emphasize role peroxisome proliferator activated receptors isotypes inflammatory metabolic adaptation astrogliosis developed ischemia neurodegenerative diseases based results reported astrocytes cells resume hypothesize effect peroxisome proliferator activated receptor ppar activation ligands different metabolic pathways order supply energy neurons activation selective ppar isotype activity may serve input better understand role played receptors metabolic inflammatory compensation astrogliosis might represent opportunity develop new therapeutic strategies traumatic brain injuries neurodegenerative diseases
paper presents design procedure tangentially magnetized variable flux machines aims reduce machine inverter rating proposed design achieve high torque density low speeds high efficiency extended speed range armature axis current pulses applied high speeds reduce magnet flux order regain full torque capability motor slows magnetizing current pulse applied amplitude magnetizing current usually larger machine rated current therefore machine may require oversized inverter order able remagnetize magnets impact different machine design parameters magnetization current requirement investigated order reduce inverter cost proposed machine design procedure validated experimental measurements variable flux machine prototype
relation different types parental care trauma childhood psychotic symptoms adulthood proposed nature association clear related psychotic disorders per cluster symptoms positive psychotic symptoms remains undefined analysed presence childhood trauma using ctq scale types parental care using pbi scale three groups subjects borderline personality disorder patients first psychotic episode patients healthy controls positive psychotic symptomatology assessed cape scale general linear models used study relation positive psychotic symptomatology variables interest bpd patients highest rate kind trauma followed fep patients found positive relationship psychotic symptomatology existence trauma childhood groups moreover affectionless control rearing style directly associated existence trauma furthermore subjects trauma presented less probability optimal parenting style childhood relation psychotic symptoms trauma remained statistically significant adjusting variables including parental rearing style seems link trauma childhood psychotic symptomatology across different populations independently psychiatric diagnosis taking account association trauma psychosis trauma modifiable factor clinicians pay special attention facts
work two active grounded equivalents third order voltage mode elliptic low pass ladder prototype proposed active building blocks abbs recently introduced current follower transconductance amplifier cfta used first active grounded filter employing eight cftas proposed interconnecting cfta based active equivalent sub blocks passive components one low impedance input terminals used since feature may cause noise injection proposed circuit proposed filter optimized using mason coates signal flow graph approach several steps number abbs reduced two unused input terminal eliminated performance novel optimized active grounded third order elliptic filter tested experimentally using readily available ucc integrated circuit
investigated problem solving abilities capuchin monkeys via floating object problem task subject must use creative problem solving retrieve favored food item bottom clear tube great apes solved problem adding water raise object level easily grabbed presented seven capuchins task eight trials four dry four wet none subjects solved task indicating capuchin demonstrated insightful problem solving experimental conditions investigated whether capuchins would emulate solution task seven subjects observed human model solve problem pouring water cup tube brought object top tube allowing subject retrieve subjects allowed interact freely unfilled tube containing object presence water objects could used solve task subjects unable solve task viewing demonstrator solve one subject unique way results consistent previous results great ape species indicate capuchins spontaneously solve floating object problem via insight
commercial vehicles common mode transport employed urban freight transport normally internal combustion engine ice vehicles powered burning fossil fuels however deteriorating air quality decreasing energy resources ice vehicles experiencing significant transition electric commercial vehicles ecvs feasible alternative alleviate emissions save energy resources proposed field urban freight transport nevertheless increasing intention adopting ecvs number employed ecvs lower ice vehicles electric passenger cars therefore paper reviewed analyzed related articles collect factors affecting employment furthermore classified factors three pillars sustainability integrating technological dimension results illustrate influence positive factors negative factors employment future work focus ranking priorities factors suggesting logistics company consider ecvs fleets thereby improving adoption sustainable urban freight transport
approximately first year medical students clinically relevant anxiety depression may affect academic success quality life study tested effects stress management intervention indicators anxiety depression self efficacy self selected first year medical students forty two medical students volunteered participate provided informed consent eight session intervention offered focused building relaxation skills adaptive coping basic nutrition anxiety depression self efficacy assessed pre post intervention group students significantly higher baseline values depression anxiety lower self efficacy compared previous study medical students institution intervention statistically significant improvements observed anxiety self efficacy depression entering levels anxiety depression group suggested students risk later clinical syndromes intervention directed decreasing effects stress associated improvement indicators distress may modify longer term risk
main purpose paper consider robust stability analysis time delay systems based parameter plane method simple systematic procedure proposed solving problem easily obtains exact stability boundaries time delay systems first relation state space representation domain characteristic equations analyzed effects state matrix time delay stability addressed approach system stabilization state feedback gain also derived performance tests proposed procedure confirm obtains information compared procedures reported literature
purpose study understand children expression verbal nonverbal communication autistic spectrum study emotional readiness music therapeutic activities exploit elements music method followed focused research field special needs education assumptions parameters investigated relation communication spontaneous interest facilitating access music games cooperation activities others classroom school yard extension family members results found communication accession elementary special education school significantly improved music therapeutic activities pedagogical practice recording high levels interest musical dance games conclusions showed content personalised music therapist activities aimed emotional organisation support communication techniques children little verbal communication
hypothalamic pituitary disconnection hpd leads low bone turnover followed bone loss reduced biomechanical properties sheep investigate role peripheral hormones centrally induced systemic bone loss model planned hormone replacement experiment therefore estrogen ohe thyroxin oht combination ohte substituted ovariectomized hpd sheep hormones decreased hpd sheep known significant yet fully understood impact bone metabolism bone turnover structural parameters analyzed comparison different control groups untreated sheep ovariectomized ovariectomized hpd sheep performed histomorphometric pqct analyses nine months hpd procedure well biomechanical testing ewes studied hpd sheep low bone turnover led significant bone loss treatment thyroxin alone oht mainly increased bone resorption leading reduction bone volume contrast treatment estrogen alone ohe combined treatment estrogen thyroxin ohte prevented hpd induced bone loss completely conclusion peripheral hormone substitution able prevent hpd induced low turnover osteoporosis sheep treatment estrogen alone combination thyroxin able completely preserve bone mass structure findings demonstrate importance peripheral hormones balanced bone remodeling physiological bone turnover elsevier ltd rights reserved
smart material electro hydraulic actuators use hydraulic rectification one way check valves amplify motion smart materials magnetostrictives piezoelectrics order create compact lightweight actuators piston pump driven smart material combined hydraulic cylinder form self contained power wire actuator used place conventional hydraulic system without need hydraulic lines centralized pump performance experimental actuator driven diameter length terfenol rod evaluated range applied input frequencies loads currents peak performance achieved moving load rate producing blocked pressure mpa additional tests conducted quantify dynamic behavior one way reed valves using scanning laser vibrometer identify frequency response reeds effect valve seat fluid mass loading lumped parameter model developed system includes valve inertia fluid response nonlinearities model results compared experimental data
care aids orphans southern africa frequently characterized crisis kin based networks care thought edge collapse yet care networks though strained aids still primary mechanisms orphan care large part essential role grandmothers play responding needs orphans ongoing demographic shifts result hiv aids increasingly feminized labor market continue disrupt alter networks care orphans vulnerable children paper examines emergence small growing number male caregivers responding needs extended family men still number strength gendered ideologies female care means group men socially statistically significant men continue considered caregivers last resort care close small growing gap threatens undermine kin based networks care lesotho across region adaptation gender roles reinforces strength resilience kinship networks even working deeply entrenched ideas gendered division domestic labor
background low levels physical activity sedentary behavior independent risk factors cardiovascular disease premature mortality people major depressive disorder mdd aims investigate levels predictors people mdd methods electronic databases searched inception till articles measuring self report questionnaire srq objective measure accelerometer people mdd random effects meta analyses meta regression analyses conducted results twenty four eligible studies identified including people mdd female mean age years range years people mdd spent min per day engaging types spent hours waking day sedentary compared controls people mdd spent less time total smd moderate vigorous smd engaged higher levels smd proportion people mdd meeting recommended guidelines studies higher studies relying objective versus self report measures people mdd less likely controls meet recommended guidelines limitations heterogeneity evident analyses conclusions adults mdd engage low levels high levels independent predictors mortality therefore future lifestyle interventions targeting prevention adoption maintenance warranted
background purpose beagley gibson grading system utilizes microtopographical skin changes generate individualized objective estimate cumulative lifetime ultraviolet radiation uvr exposure however predictors grade ill defined particularly older populations aim cross sectional study describe factors associated skin damage measured method community dwelling older adults methods study participants aged years silicone casts taken dorsum hands graded method lifetime sun exposure skin phenotypic traits smoking status assessed questionnaire hydroxyvitamin melanin density measured using radioimmunoassay spectrophotometry respectively ordered logistic regression used compute single odds ratio taking grade outcome variable results higher hydroxyvitamin associated increasing grade adjusted analysis age occupational sun exposure ability tan melanin density lifetime leisure time sun exposure current smoking propensity sunburn waist hip ratio independent predictors grade hair colour number sunburns body mass index gender independent predictors grade conclusions beagley gibson skin cast grade biologically relevant marker uvr exposure older adults influenced intrinsic extrinsic factors
paper regenerative lens focused upon new conceptual game system involving transaction costs tcs creating accessible green buildings market individual stakeholders steadfastly guard interests investment decision seldom considers positive gains society green buildings branded partial public goods involve rational irrational factors incurring extra transaction costs tcs affecting willingness stakeholders take part paper examines reduce tcs incurred game played decision making process ultimate aim promoting game model developers end users negotiate bargain tcs caused comparison conventional counterpart findings tcs overriding barriers impeding development market reducing tcs facilitate supply demand market equilibrium payoffs developer end user proportional bargaining powers higher bargaining power benefit gain transaction strengthening bargaining power developer increase expected utility developing fake products less credible developers result higher tcs end users therefore lower payoffs expected findings stress choice developers end users investing complex game problem tcs could conceptualized showed important role minimizing tcs incurred complex decision benefit also bring net regenerative outcomes society elsevier ltd rights reserved
humanitarian aid information information occurrences disaster situations victims shelters resources facilities usually rapidly dynamic ambiguous huge system humanitarian aid often involves data items frommultidisciplinary environments similar meanings appear structurally different various data sources achieve semantic interoperability among humanitarian aid information systems exchanged meaningful information paper contributes methodology construction application independent ontology proposes guideline merging information different databases application independent ontology helps people integrate systems minimal modification demonstrate develop ontology humanitarian aid refugee emergencies hare common ontology sharing use current knowledge bases discuss approach merging relational databases rdbs heterogeneous hierarchical ontology
pro social behaviours may prompted inhibited depending situation numerous experiments show exposed idea money people less willing help devote time share resources others vohs science current directions psychological science conversely exposed idea spirituality often cheat less willing help others mazar ariely journal marketing research randolph seng nielsen international journal psychology religion aim article present results two experiments activated thoughts money cash credit cards thoughts spirituality order find way two kinds activation may influence pro social behaviours experiment participants reminded money offered lower donations others whereas reminded spirituality offered higher donations experiment participants reminded money offered devote less time help others whereas reminded spirituality offered devote time help others
objective historically marginalized groups likely exposed social adversity predicts important mental health outcomes depression despite well established relationship adversity poor health studies examined adversity differentially predicts mental health among people living multiple occurring marginalized identities statuses current study fills gap examining whether relationships social adversity depressive symptoms differed living without stigmatized disease hiv marginalized racial ethnic identity african american method community sample men women completed questionnaires assessing demographics depressive symptoms additionally composite index social adversity derived measures perceived discrimination socioeconomic status financial restriction receiving medical care perceived neighborhood characteristics multiple regression used test whether relationships adversity depressive symptoms differed function hiv status racial ethnic identity results significant way interaction social adversity hiv status racial ethnic identity indicated direct relationship adversity depressive symptoms hiv positive hiv african americans hiv negative hiv african americans hiv caucasians hiv caucasians hiv african americans evidenced significantly greater relationship adversity depressive symptoms compared hiv african americans compared groups conclusions findings suggest hiv african americans may risk higher depressive symptoms amid adversity highlighting importance evaluating intersectional identities statuses context mental health
management uncertain data spatial queries drawn extensive research interests consider granularity devices noises collection delivery data previous works usually model handle uncertain data find required results directly however difficult users obtain useful insights data uncertainty dramatically increases case users usually willing invest resources improve result reducing data uncertainty order obtain interesting observations existing schemes light important need paper formulates new problem selecting given number uncertain data objects acquiring attribute values improve result probabilistic nearest neighbor pnn query prove better query results guaranteed returned data acquisition devise several algorithms maximize expected improvement first explore optimal single object acquisition pnn examine fundamental problem structure propose efficient algorithm discovers crucial properties simplify probability derivation varied situations extend proposed algorithm achieve optimal multi object acquisition pnn deriving upper bound facilitate efficient pruning unnecessary sets objects moreover data acquisition pnn extract pnn answers sufficiently large probabilities trim search space properly exploit result single object acquisition estimating gain multi object acquisition experimental results demonstrate probability pnn significantly improved even small number objects data acquisition
present case year old male presented reporting month history lowered mood fatigue anhedonia disturbed sleep heightened anxiety questioning reported restricted eating weightlifting least daily basis investigations revealed findings compatible secondary hypogonadism potential causes secondary hypogonadism including structural lesions muscle dysmorphia use illicit anabolic steroids discussed
rapid development internet especially emergence social networks leads rumor propagation new media era rumor propagation social networks brought new challenges network security social stability paper based partial differential equations pdes proposes new sis rumor propagation model considering effect communication different rumor infected users rumor propagation stabilities nonrumor equilibrium point rumor spreading equilibrium point discussed linearization technique upper lower solutions method existence traveling wave solution established cross iteration scheme accompanied technique upper lower solutions schauder fixed point theorem furthermore add time delay rumor propagation deduce conditions hopf bifurcation stability switches rumor spreading equilibrium point taking time delay bifurcation parameter finally numerical simulations performed illustrate theoretical results
smart material nanoassemblies simultaneously sense shoot low level contaminants air water important overcoming threat hazardous chemicals graphene oxide sheets deposited mesoscopic tio films underpin deposition nanoparticles irradiation provide foundation design smart material particle size readily controlled precursor concentration irradiation time semiconductor graphene oxide metal sgm films sers active hence capable sensing aromatic contaminants nitrobenzenethiol nbt nanomolar range increased local concentration organic molecules achieved interaction carbon support facilitates low level detection contaminants upon irradiation nbt loaded sgm film one induce photocatalytic transformations thus component sgm film plays pivotal role aiding detection degradation contaminant dispersed aqueous solutions advantage using sgm films multipurpose detect destroy systems nitroaromatic molecules discussed
ecological perspective nature rainwater harvesting characteristics artificial disturbance manual disturbance important confirm degree ecological disturbance occurs due rainwater harvesting drawing ecological disturbance theory utilize distance method dynamic curve method estimate level ecological disturbance degree rainwater harvesting historical reference point value environment frame reference indicators surface runoff evaluation index examples show distance method dynamic curve method feasible evaluating ecological disturbance degree rainwater harvesting also research scale effects study ecological disturbance rainwater harvesting embody comparability different spatial temporal ecological disturbance degrees comparability ecological disturbance degrees rainwater harvesting area different scales different areas scales strong also generates useful reference values ecological disturbance measurement study area research scale different historical periods compared
examined extent arginine vasopressin receptor avpra dopamine receptor drd related sensitive maternal behavior directly indirectly via maternal social cognition participants european american african american mothers children females sensitive maternal behavior rated aggregated across series tasks infants months year years old months mothers interviewed empathy attributions infant behavior beliefs crying assess parenting related social cognition mothers long alleles avpra drd engaged mother oriented social cognition negative attributions beliefs infants crying beta beta respectively turn predicted less sensitive maternal behavior beta indirect effects statistically significant independent one another covariates confidence interval beta avpr beta drd significant direct effects avpra drd maternal sensitivity beta beta respectively results vary african american european american mothers delta chi delta results support view one mechanism maternal genes associated parental behavior via social cognition
aim study investigate antibacterial effects immunodominant proteins isolated venom naja naja oxiana snake staphylococcus aureus escherichia coli bacillus subtilis pseudomonas aeruginosa innate immune system important line defense bacterial diseases antibacterial peptides proteins produced snake venoms recently attracted significant attention due relevance bacterial diseases potential converted new therapeutic agents identification immunodominant proteins venom naja naja oxiana snake performed sds page western blot analysis identified proteins isolated directly preparative gel electrophoresis electro elution next step antibacterial effects immunodominant proteins tested several strains clinical isolates including aureus subtilis gram positive bacteria aeruginosa coli gram negative bacteria using broth microdilution disc diffusion assays order compare results discdiffusion assay antibacterial effects several antibiotics gentamicin ampicillin penicillin amoxicillin ciprofloxacin also examined using conditions results showed immunodominant proteins kda high immunogenicity effective inhibiting growth two gram positive bacteria aureus sub tested however moderately effective inhibiting growth two tested gram negative bacteria aeruginosa coli however immunodominant proteins kda kda high immunogenicity showed slight effectiveness inhibiting growth two gram positive gram negative bacteria tested best knowledge immunodominant proteins novel antigens potent antimicrobial effects two gram positive bacteria aureus subtilis less antimicrobial effect two gram negative bacteria coli aeruginosa prepared
objective parameter optimization thermal system increase system efficiency decrease cost unit output power condition total output power meet actual requirements energy applications paper new parameter optimization method actual thermal system proposed called equivalent transformation constant state finite time thermodynamic analysis method two calculation steps first step choosing optimum efficiency principle taking account output power efficiency weights second step calculating optimum total heat transfer coefficient ratio concerned parameters optimum efficiency fixed related calculation principles formulas parameter optimizations method given provided guiding theoretical basis actual thermal system efficiency increase cost decrease unit output power elsevier ltd rights reserved
type norm adaption penalized least mean square fourth lms algorithm proposed sparse channel estimation applications proposed lms algorithm realized incorporating norm like cost function conventional least mean square fourth lms acts combination norm constraints reweighted lms rna lms algorithm also developed adding reweighted factor lms algorithm proposed rna lms algorithm exhibits improved performance terms convergence speed steady state error provide zero attractor exploit sparsity channel use norm adaption penalty reweighting factor simulation results obtained sparse channel estimations given verify proposed rna lms algorithm superior previously reported sparse aware lms conventional lms algorithms terms convergence speed steady state behavior elsevier rights reserved
menstrual disorders common among female athletes ballet dancers endocrine changes high testosterone levels high luteinizing hormone follicle stimulating hormone fsh ratios may suggest functional ovarian hyperandrogenism may induce dysfunction aim study therefore evaluate endocrine status female athletes ballet dancers menstrual disorders nutritional status dietary habits analysed relation testosterone levels cross sectional approach female athletes years ballerinas menstrual disorders participated study levels serum fsh progesterone estradiol prolactin prl thyroid stimulating hormone testosterone sex hormone binding globulinwere measured assess hormonal status addition free androgen index fai calculated nutritional status total daily energy expenditure nutritional habits evaluated girls assigned one following groups low testosterone level normal testosterone level level significant differences ballerinas female athletes terms testosterone levels fai age beginning training length training period age menarche prl level lowest group fai index highest group daily energy carbohydrate intakes significantly lower group levels study subjects found associated nutritional factors energy availability age beginning training frequency training first report levels associated status female ballet dancer age menarche length training history research necessary confirm results larger study group
widespread use internet significantly changed behavior homebuyers using online real estate agents homebuyers rapidly find modern houses meet needs however current online housing systems provide limit features particular existing systems fail consider homebuyers housing goals risk attitudes increase effectiveness online real estate agents provide efficient matching mechanism personalized service house ranking aim increasing buyers satisfaction deal rate efficient online real estate agent provide easy way homebuyers find rank suitable house alternatives consideration different housing philosophies risk attitudes order comprehend ambiguous housing goals risk attitudes also indispensable determine satisfaction level fuzzy goal constraint study propose fuzzy goal programming shaped utility function decision aid help homebuyers choosing preferred house via internet easy way use decision aid homebuyers specify housing goals constraints different priority levels thresholds matching mechanism fuzzy search matching mechanism translated standard query language regular relational database moreover laboratory experiment conducted real case demonstrate effectiveness proposed approach results indicate proposed method provides better customer satisfaction manual systems housing selection service elsevier rights reserved
serial multi class contour preserving classification improve representation contour data improve levels classification accuracy feed forward neural network ffnn algorithm synthesizes fundamental multi class outpost vector fmcov additional multi class outpost vector amcov decision boundary consecutive classes data narrow space data fmcovs amcovs assist ffnn place hyper planes way classify data accurately however technique designed utilize one processor result execution time algorithm significantly long article presents improved version serial multi class contour preserving classification overcomes time deficiency utilizing thread level parallelism support parallel computing multi processor multi core system parallel algorithm distributes data set processing fmcov amcov generators operated available threads increase cpu utilization speedup factors fmcov amcov generators technique carefully designed avoid data dependency issue experiments conducted synthetic real world data sets experimental results confirm parallel multi class contour preserving classification clearly outperforms serial multi class contour preserving classification terms cpu utilization speedup factor
backgroundcallous unemotional behaviors identify children risk severe chronic antisocial behavior research needed establish pathways temperament parenting factors give rise callous unemotional behaviors including interactions positive versus harsh parenting child fearlessness methodsmultimethod data including parent reports observations parent child behavior drawn prospective longitudinal sample low income boys assessments months ages years old resultsparent reported callous unemotional oppositional attention deficit factors separable months callous unemotional behaviors months predicted callous unemotional behaviors ages accounting earlier oppositional attention deficit behaviors self reported child delinquency ages observations fearlessness months predicted callous unemotional behaviors months parents exhibited low observed levels positive parenting interaction fearlessness low positive parenting indirectly predicted callous unemotional behaviors via callous unemotional behaviors months conclusionsearly fearlessness interacts low positive parenting predict early callous unemotional behaviors lasting effects person context interaction callous unemotional behaviors late childhood
article discusses barriers reducing unintended pregnancy numerous factors may explain high rate unintended pregnancy united states including inadequate sex education confusing media messages sex cultural attitudes sex young parenting conflation contraception abortion inadequate health care access burdensome contraceptive dispensing practices hospital merger limitations care successful promising approaches expanding access reproductive health care reducing unintended pregnancy discussed
project addresses need interfacing circuit biosensor measurement system operates immobilization hybridization process purpose project design readout circuit capture redox reaction electrolyte sense small current changes working electrode electrode electrochemical biosensor measurement system potentiostat consist current voltage converter convert input current output voltage potentiostat also medium biasing electrodes electrochemical technique also consists several amplifiers amplify input could read microcontroller potentiostat able detect low microamperes changes working electrode
manuscript presents method model detail piezoelectric traveling wave rotary ultrasonic motor ptrusm stator response action voltages stator modeled discrete two dimensional system equations using finite volume method fvm order obtain accurate results model stator bridge included stator model model stator action voltage presented first results model compared versus similar model using commercial finite element software comsol multiphysics one observe difference less displacements stator using proposed model one comsol multiphysics model stator action voltages presented time domain analysis shows generation traveling wave stator surface one use model accurately calculate stator surface velocities elliptical motion stator surface amplitude shape stator traveling wave system equations discretized finite volume method easily transformed electrical circuits fvm may better choice develop model based control strategy ptrusm elsevier rights reserved
backgrounds effects electroconvulsive therapy ect bilateral left prefrontal right prefrontal repetitive transcranial magnetic stimulation rtms major depressive disorder mdd adequately addressed previous studies multiple treatments meta analysis incorporates evidence direct indirect comparisons network trials performed assess efficacy acceptability four treatment modalities mdd method literature searched randomized controlled trials rcts ect bilateral rtms unilateral rtms treating mdd may main outcome measures response drop rates results data obtained studies consisting individuals mdd ect non significantly efficacious rtms rtms rtms left prefrontal rtms non significantly less efficacious treatment modalities terms acceptability rtms non significantly better tolerated ect rtms rtms ect efficacious treatment cumulative probabilities efficacious treatment ect rtms rtms rtms rtms best tolerated treatment cumulative probabilities best tolerated treatment rtms rtms rtms ect coherence analysis detected statistically significant incoherence comparisons direct indirect evidence response rate drop rate conclusions ect efficacious least tolerated treatment rtms best tolerated treatment mdd rtms appears favorable balance efficacy acceptability elsevier rights reserved
background individuals autism spectrum disorder asd show relative indifference human voice accordingly contrarily typically developed peers adults autism show preferential response voices superior temporal sulcus lack voice specific response previously linked atypical processing voices electroencephalography slow event related potential erp called fronto temporal positivity voice ftpv larger vocal non vocal sounds resulting voice sensitive response right fronto temporal sites investigated neurophysiological correlates voice perception children without asd methods sixteen children autism age matched typically developing children heard vocal speech non speech non vocal sounds electroencephalographic activity recorded overall smaller group children asd erp amplitudes compared using non parametric statistical tests electrode successive time windows within group differences conditions assessed using non parametric quade test post stimulus inter group comparisons erp amplitudes performed using non paired kruskal wallis tests post stimulus results typically developing children showed classical voice sensitive response right fronto temporal electrodes speech non speech vocal sounds children asd show preferential response vocal sounds inter group analysis showed difference processing vocal sounds speech non speech significant differences processing non vocal sounds right fronto temporal sites conclusions results demonstrate lack voice preferential response children autism spectrum disorders contrast observations adults asd lack voice preferential response attributed atypical response non vocal sounds overall similar event related potentials evoked vocal sounds groups result suggests atypical maturation processes asd impeding specialization temporal regions voice processing
present study aims analyze role parenting styles development suicidal ideation adolescents well test mediating role attachment parents association authoritative authoritarian permissive parenting style suicidal ideation sample made individuals aged order gather data styles dimensions questionnaire short version father mother attachment questionnaire suicidal ideation questionnaire used results suggest relations parents characterized inhibition exploration individuality contribute emotional maladjustment positively associated suicidal ideation confirmed mediating role parental attachment association authoritative permissive parenting styles father mother suicidal ideation also verified also partial mediation attachment parents association parent authoritarian style mother permissive styles suicidal ideation furthermore found presence total mediation throughout attachment father association father permissive style suicidal ideation results suggest importance adopting authoritative parenting styles since seem facilitate development quality attachment parents results analyzed light attachment theory taking consideration importance parenting styles understanding processes inherent suicidal ideation adolescence
settling behavior operational amplifiers opamps important many analog signal processing applications paper analysis single stage opamps based settling time performed simple yet accurate model settling response first order opamps modifies conventional models proposed revise equations presented approach leads new simple settling based design methodology single stage operational amplifiers circuit level simulations demonstrate effectiveness procedure
much research video games focused aggressive outcomes extant research come consensus role factors notably enjoyment frustration individual differences amongst players mediating link violent game play aggression experimental design uses mental models approach examine game features controller naturalness player characteristics first person shooter experience sex degree competitiveness game play experience perceived game realism immersion game failure frustration enjoyment explain aggressive outcomes results revised path model suggest perceived realism immersion experience first person shooters positively predicted enjoyment frustration negatively predicted game enjoyment frustration enjoyment predicted state aggression findings study support application mental models theoretical approach unify thinking violent games contextual features violent games individual difference variables differences player perceptions game experiences regards outcome aggression results discussed terms model matching hypothesis implications comprehensive study violent game play including importance enjoyment frustration also discussed elsevier ltd rights reserved
objective summarize evidence regarding current demand demand oral contraception study design used medline collegial contacts find published unpublished studies conducted reported past years information assessing women interest using oral drug preparation including emergency contraceptive pills coitus dependent manner either repeatedly primary planned pregnancy prevention method results found studies relevant information studies conducted countries eight studies provided data women attitudes regarding coitus dependent oral contraceptive suggested substantial interest using nine studies assessed actual use oral tablets demand primary contraception studies women analysis populations reported using pills demand main method although frequency consistency use varied reported reasons interest use contraceptive approach included convenience ease remembering ability conceal use lack coital interruption infrequent sexual activity three studies clinical trials investigational demand oral contraceptives reported pearl indices ranging pregnancies per woman years conclusion data variety settings suggest demand demand oral contraceptive may widespread effectiveness potential method established however considering seriousness unmet need contraception development research public health benefits risks method would worthwhile elsevier inc rights reserved
consider generalized fifth order kdv type nonlinear evolution equation variable coefficients system technique applied rigorously order find new exact solutions considered equations closed form solutions fifth order kdv type nonlinear evolution equation expressed proposed ansatz terms exponential functions believe system technique effective stable finding exact solutions nonlinear evolution equations describe behaviors obtained solutions certain constraints variable coefficients authors published elsevier
learning objectives participating activity learners better able evaluate evolution social cognitive abilities developmental process assess evidence regarding social cognition difficulties youth clinical high risk psychosis individuals clinical high risk chr psychosis exhibit broad range difficulties including impaired social cognition may represent target early identification intervention several studies examined various domains social cognition chr individuals focus adolescent young adult populations given accumulating evidence impairment exists onset psychotic disorders critically important begin look risk markers younger children present article reviews studies chr examine following four domains social cognition emotion processing theory mind social perception attribution bias eligible studies identified comprehensive literature search conducted using electronic databases including pubmed medline psycinfo combinations key social cognition chr search terms despite mixed results existing literature establishes chr individuals display social cognitive impairment though remains unclear impairment develops thus using literature social cognition typically developing children model reference looking evolution social cognitive abilities developmental process review presents valuable new perspective indicates necessity investigation younger risk populations implications treatment future research discussed
introduction hypertrophic osteoarthropathy hoa orphan disease characterized digital clubbing periostitis tubular bones arthralgia arthritis disease may classified primary secondary pulmonary intra thoracic diseases cause secondary forms areas covered diagnosis generally based presence triad symptoms including digital clubbing periostitis distal end tubular bones painful swelling limbs associated bilateral symmetrical arthritis large joints radiographic evaluation assessment reference diagnosis vascular endothelial growth factor vegf platelet derived growth factor pdgf seem key mediators pathogenesis disorder treatment prognosis depend hoa underlying cause cases treatment associated malignancy solve improve clubbing bisphosphonates may role symptomatic treatment hoa expert opinion clinical practice primary hoa rare secondary form relatively frequent may mimic rheumatologic conditions notably hoa considered differential diagnosis painful arthritis periosteal bone involvement clubbing periostitis become evident previously healthy individual comprehensive search underlying illness undertaken
confinement critically ill patients intensive care units icu imposes environmental constancy throughout day night continuous light noise caring activities medications etc negative impact human health inducing new syndrome known circadian misalignment circadian disruption chronodisruption syndrome contributes poor sleep quality delirium may impair septic states frequently observed critically ill patients however although bidirectional crosstalk sleep impairment delirium inflammation animal models known years suspected icu patients changes introduced environment management icu patients improve circadian rhythmicity delirium serious condition severe effect prognosis increases mortality well sleep impairment sepsis three linked disorganization circadian system critically ill patients revised considering functional organization circadian system main input output signals synchronize clock including brief description molecular circadian clock machinery non visual effects light icu light environment finally potential usefulness increased light dark contrast melatonin treatment context analyzed including practical countermeasures minimize circadian disruption improve circadian system chronoenhancement helping make units optimal healing environments patients
alpha synuclein protein involved pathogenesis synucleinopathies including parkinson disease dementia lewy bodies dlb multiple system atrophy msa investigated role neuronal alpha syn myelin composition abnormalities phospholipid content purified myelin determined nmr two mouse lines modeling prp alpha syn thy alpha syn significantly higher levels phospholipids detected myelin purified brains alpha syn transgenic mouse models control mice nevertheless myelin ultrastructure appeared intact investigate effect alpha syn myelin abnormalities systematically analyzed striatum brain region associated neurodegeneration age diseasedependent loss myelin basic protein mbp signal detected immunohistochemistry striatal striosomes patches age dependent loss mbp signal associated lower levels oligodendrocytes addition found alpha syn inhibited oligodendrocyte maturation formation membranous sheets vitro based results concluded neuronal alpha syn involved regulation maintenance myelin phospholipid however axonal hypomyelination models evident progressive stages disease associated alpha syn toxicity
investigated mid long term results transcatheter closure atrial septal defect asd patients years since issues patients presenting pulmonary hypertension arrhythmia time closure year period transcatheter closure asd successful patients aged years failed patients males median years nyha functional class presence arrhythmia severity pulmonary hypertension compared closure patients pulmonary hypertension significantly older years required larger devices without arrhythmia intervention documented patients atrial fibrillation atrial flutter supraventricular tachycardia patients atrial flutter significantly older years higher pulmonary artery mean pressure mmhg without mean follow period years early new onset arrhythmia documented patients persistent developed sick sinus syndrome others sinus rhythm latest visit significant improvement nyha functional class closure patients sinus rhythm paroxysmal persistent pulmonary hypertension persisted patients transcatheter closure atrial septal defect patients years beneficial terms nyha functional class pulmonary artery pressure cardiac rhythm
objective assess checklist reminding clinicians deliver bundled intervention affects contraceptive knowledge use months women seek walk pregnancy testing methods pre intervention inner city family planning clinic provided unstructured care intervention period clinic staff used checklist ensure women received needed services women seeking walk pregnancy testing wished avoid pregnancy least months asked complete surveys contraceptive knowledge use immediately months visiting study clinic assess significance changes time used logistic regression models results january may women sought pregnancy testing study clinic completed surveys pre intervention intervention period checklist intervention participants likely receive emergency contraception aor intrauterine device implant placed time clinic visit receive contraceptive prescription three months visiting study clinic participants intervention period knowledgeable intrauterine subdermal contraception likely using intrauterine subdermal injectable contraception conclusions women seeking walk pregnancy testing appear likely receive switched effective form birth control months following visit clinic staff used item checklist provided scripted counseling implications checklist reminding clinic staff assess pregnancy intentions provide scripted counseling emergency highly effective reversible contraception offer day contraceptive initiation women seeking walk pregnancy testing appears increase use effective contraception elsevier inc rights reserved
electrocorticogram ecog great potential source signal especially clinical bmi recently ecog electrodes commonly used identifying epileptogenic foci clinical situations electrodes low density large increasing number density recording channels could enable collection richer motor sensory information may enhance precision decoding increase opportunities controlling external devices several reports aimed increase number density channels however studies discussed actual validity high density ecog arrays study developed novel high density flexible ecog arrays conducted decoding analyses monkey somatosensory evoked potentials seps using mems technology made channel parylene electrode arrays inter electrode distance recording site area arrays mainly placed onto finger representation area somatosensory cortex macaque partially inserted central sulcus electrical finger stimulation successfully recorded visualized finger seps high spatiotemporal resolution conducted offline analyses stimulated fingers intensity predicted recorded seps using support vector machine obtained following results high accuracy similar achieved short segment data similar stimulus onset high accuracy similar achieved even single channel used result indicated placement optimality decoding higher channel counts generally improved prediction accuracy efficacy small predictions feature vectors included time series information results suggest ecog signals high spatiotemporal resolution could enable greater decoding precision external device control
aiming support school based outdoor learning opportunities paper critiques extent deweyan neo aristotelian theorising helpful highlighting personal growth practical wisdom gains realised critique necessary signs implementation gap practice policy made worse lack conceptual clarity educational aspirations dependably achieved dewey habit forming social constructivist emphasis learning problem solving reviewed prospects neo aristotelian conception human flourishing recognises virtues nurtured moral sensitivities considered concerns dewey writings often vague ideas operationalised criticisms aristotle educational thoughts rather privilege cognition relative emotions also addressed article concludes teasing suggestions deweyan neo aristotelian ideas learning might coherently inform curriculum planning pedagogical practices
backgroundafrican americans multiple sclerosis aawms different disease phenotypes compared caucasians americans cawms pathologic basis difference disease presentation unknown methodsfifty four aawms cawms appropriately matched age gender treatment duration disease duration freesurfer used segment brain white matter gray matter images compute thalamic volume regional cortical thickness calculated using qdec resultsthe matched cohorts differed disability aawms demonstrating significantly higher edss scores yet populations similar hyperintense lesion volumes aawms significantly lower total global cortical thickness compared cawms controlling edss aawms showed multiple cortical regions significantly thinner cawms included areas within temporal parietal occipital lobes well precentral postcentral gyrus middletemporal cortex affected aawms left hemisphere superiortemporal cortex affected right hemisphere contrast thalamic volume significantly reduced cawms compared aawms groups worse disability associated lower total thalamic volume percentage conclusionaawms cawms patients differ regard global regional cortical thickness thalamic volume diverging pattern gray matter volumetrics among otherwise matched patients suggests racial specific disease differences may exist
attracting new tourists important issue destination marketing also imperative manage tourists experience post trip particularly cases unsatisfying experiences yet questions rectify unsatisfying tourism experiences received little attention tourism scholarship present research investigated effectiveness different forms marketing messages role counterfactual thinking ability marketing message improve tourists attitudes towards destination intentions recommend tourism experience tourists satisfaction scenario based experiment conducted respondents results showed user generated messages messages employing emotional appeal impactful destination generated rational messages respondents engaged downward counterfactual thinking imagining situation experience could worse shown greater positive effect unsatisfied tourists elsevier ltd rights reserved
edaphic landscape restoration performed two anthracite coal mine spoil heaps located spain demonstration pilot program restoration coal mine spoils terrestrial arthropods used monitor process alternative use secondary succession plants physico chemical indicators soils study analyzes usefulness terrestrial arthropods different taxonomic levels orders arthropoda families coleoptera species carabidae restoration indicators initial restoration stages terrestrial arthropods respond rapidly restoration results may explained short term increase abiotic factors resulting applied techniques mainly animal origin organic matter added biodegradable coconut geotextile carabidae relatively low value short term restoration indicator specific level coleoptera provided best information interpreting ecological results short term best relationship cost identification likewise results showed edaphic landscape restoration leads abnormal arthropod assemblage short term excessive abundance isopods polydesmids clear convergence appeared toward terrestrial arthropod communities present grassland scrubland woodland semi natural areas used reference end point restoration indicator value produced higher taxonomic levels studied terrestrial arthropods may useful cost effective assessing short term changes caused environmental restorations performed recover ecosystems affected mining activities copyright john wiley sons ltd
motivation important factor successful instruction factor especially relevant collaborative learning contexts social interaction plays important role paper present evaluation motivation students instructed four pedagogical approaches traditional lecture collaborative learning collaborative learning guided cif instructional framework collaborative learning collaborative learning guided cif supported mocas collaborative learning tool considered four dimensions motivation according self determination theory statistical results show global terms students motivated jointly using collaborative instructional approach cif mocas tool using collaborative approach detailed analysis different kinds motivation yields mixed results students instructed cif especially students instructed cif mocas exhibited higher intrinsic motivation furthermore students instructed cif mocas extrinsically motivated via identified regulation respect extrinsic motivation via external regulation students instructed traditional individual way motivated students instructed collaboratively finally high levels amotivation also associated instruction using cif mocas summary results suggest cif mocas associated high levels intrinsic extrinsic motivation finding aid improving learning processes also unexpectedly associated amotivation suggesting overall increase activation students show mixed motivators elsevier ltd rights reserved
seismic analysis long span cable suspended bridges undoubtedly problem structural analysis involves high number uncertain parameters work probabilistic approach monte carlo simulation seismic analysis carried able take account variability certain factors relating seismic input displacement time histories necessary define seismic scenarios built artificially based response spectrum site analysis carried using numerical model built using one dimensional finite elements using adina software code model developed conjunction purpose built program fortran language conduct monte carlo simulations results expressed terms displacements stresses described average value variance elsevier ltd rights reserved
previously generated oral hepatitis virus hcv vaccine using bifidobacterium displaying hcv nonstructural protein polypeptide specific cellular immunity important viral clearance recovery hcv infection study enhanced cellular immune responses induced oral hcv vaccine bifidobacterium longum longum combining interferon alpha ifn alpha adjuvant vaccine mouse experimental model ifn alpha widely used cytokine meeting standard care soc hcv infection plays various immunoregulatory roles treated cbl mice longum every day ifn alpha twice week month analyzed immune responses using spleen cells determined induction specific cellular immunity cytokine quantification intracellular cytokine staining cytotoxic lymphocyte ctl assay targeting tumor cells expressing protein also treated mice bearing tumor combination therapy vivo results confirmed combination therapy longum ifn induced significantly higher ifn gamma secretion higher population cells secreting ifn gamma higher ctl activity cells compared control groups phosphate buffered saline longum alone ifn alpha alone also confirmed combination therapy strongly enhanced tumor growth inhibitory effects vivo serious adverse effects results suggest combination longum ifn alpha could induce strong cellular immunity specific protein combination therapy augmenting current soc immunotherapy chronic hcv infection
quinoxaline derivatives also called benzopyrazines important class heterocyclic compounds quinoxalines drawn great attention due wide spectrum biological activities considered important basis anticancer drugs due potential activity protein kinase inhibitors review focus chemistry quinoxaline derivatives strategies synthesis potential activities various tyrosine kinases structure activity relationship studies reported date
new algorithm driven methodology introduced synthesis data conversion systems employs combination symbolic signal flow graph techniques generate canonical representation algorithm description together pattern recognition techniques determine appropriate functional building blocks converter architecture knowledge based rules instantiate building blocks electrical subcircuits allowing synthesis process move higher levels abstraction proposed methodology provides computer based framework systematic uniform treatment various types conversion systems including search new conversion algorithms new implementation architectures
researchers interested psychological factors affecting writers higher education institutions academic writers concerned internal variables affecting writing productivity however empirical studies explore factors samples students process earning master doctoral degrees graduate students study examined writing anxiety self efficacy emotional intelligence sample graduate students large research intensive university united states using survey collected measures variables addition demographic information participants used measures descriptively compare groups students similar characteristics run three regression models identify variables best predicted writing anxiety findings indicate self efficacy statistically significant large predictor writing anxiety though descriptive data showed moderate effects first language whether student reported english first language presence self efficacy gender remained significant predictor writing anxiety first language discuss implications future research practice focused helping graduate student academic writers succeed
operating conventional spooler system heavy industries winch reel cranes wire rope tangling twisting leads wire aging short life cycle entangling occurs catastrophic damage whole system aim work investigating tension control system using magneto rheological brake mrb provide back tension prevent frequent part changes fatal malfunction order achieve aim basic mrb first designed analyzed using finite element method fem electromagnetic field fluid analysis performed second step prototype mrb fabricated optimized structural parameters experimental apparatus constructed moreover output torque characteristics designed mrb various input current rotational speed evaluated consequently conventional proportional integral derivative pid controller designed tension control control results show feasibility tension control winch spooler system
effects hydrologic cycle change caused human activity global climate change ecosystems attract increasing attention around world result impounding three gorges dam tgd climate change sand mining dry season poyang lake dongting lake china two largest freshwater lakes came early tgd impoundment primary cause increasing need sluice dam construction store water lakes attracted increasing attention paper compared landscape pattern three hydrologic years early dry season three normal hydrologic years lake remote sensing technology reveal effect early dry season landscape pattern results showed early dry season caused expanding phalaris mudflat zone poyang lake caused expanding carex phalaris zone expanding phalaris mudflat zone dongting lake landscape level significant difference landscape grain size landscape grain shape habitat connectivity landscape diversity two lakes habitat class level significant changes area mudflat phalaris grain size mudflat poyang lake area carex grain size phalaris grain shape carex phalaris dongting lake changes impact migrating birds east asian migratory fishes yangtze river elsevier rights reserved
energy harvesting techniques combined wireless embedded sensors obtain battery free platforms extended lifetime although energy harvesting offers continuous supply energy delivery rate typically limited joules per day severe constraint achievable computing throughput embedded sensor node achievable latency obtained applications running nodes paper address constraints precomputation idea reduce amount computations required response application inputs partitioning algorithm offline part computed inputs available online part computed response actual input show technique works well hash based cryptographic signatures complex key generation new message requires signature precomputing key material storing run time coupons non volatile memory drastic reduction run time energy needs signature drastic reduction run time latency generate winternitz hash based scheme bit quantum security level msp microcontroller measured run time energy reduction run time latency reduction
cross sectional study sought determine factors associated sterilization among hiv positive women hiv positive women aged completed audio computer assisted self interview acasi questionnaire chi square tests multivariable logistic regression evaluated factors associated sterilization median age participants majority least high school education african american nearly quarter women undergone sterilization average age women cited hiv positive status important factor deciding tubal ligation expressed desire future children reported sterilization regret reported feeling pressure undergo sterilization multivariable analysis factors significantly associated sterilization included non african american race desire future pregnancy heard birth control methods making harder get pregnant future belief women take break hormonal methods every years child born hiv almost quarter hiv positive group sterilized many height early hiv epidemic large proportion sterilized women expressed sterilization regret counseling messages sterilized hiv positive women sensitive fact women may regret regarding decision cases may historically part provider recommendations prevent vertical transmission hiv improved knowledge contraceptive options iud implant needed among hiv positive women
aim previous literature shown leisure time physical activities associated better sleep aim study explore effects leisure time aerobic exercise muscle strength activity sleep duration subjects methods data national health interview survey sample adult public use file analyzed age gender region race smoking drinking stress anxiety considered potential confounders univariate multivariate multinomial logistic regression models fitted estimate effects aerobic exercise muscle strength activity sleep duration results total adults eligible study sleep day fewer sleep day sleep day fully adjusted models reference lowest level aerobic exercise quartiles sleeping respectively fully adjusted models muscle strength activity show compared lowest level muscle strength activity ors excessive muscle strength activity sleeping conclusion findings suggest high levels leisure time aerobic exercise play protective role healthy sleep excessive muscle strength activity might increase risk extremely short long sleep durations
aspergillosis face affects nose eyes mainly invasive particular fulminant forms associated high mortality report case sino orbital aspergillosis known case diabetes mellitus patient underwent surgery debridement right maxillary sinus transnasal approach successful treatment aspergillosis requires prompt diagnosis institution therapy delay non aggressive therapy result spread infection lethal consequences
aims bipolar disorder characterized behavioral changes risk taking increasing goal directed activities may result altered reward processing patients bipolar disorder show impaired reward learning situations require integration reinforced feedback time study examined behavioral electrophysiological characteristics reward learning manic euthymic patients bipolar disorder using probabilistic reward task methods twenty four manic euthymic patients bipolar disorder healthy control subjects performed probabilistic reward task assessed response bias preference stimulus paired frequent reward feedback related negativity frn correct identification rich stimulus results manic euthymic patients showed significantly lower scores early learning stage block comparison late learning stage block block task well significantly lower scores early stage compared healthy subjects relatively negative frn amplitude elicited presentation expected reward compared elicited presentation expected feedback frn became significantly negative early block later stages blocks manic euthymic patients healthy subjects changes scores frn amplitudes blocks block correlated positively healthy controls correlated negatively manic euthymic patients severity manic symptoms correlated positively reward learning scores negatively frn conclusions findings suggest patients bipolar disorder euthymic manic states behavioral electrophysiological alterations reward learning compared healthy subjects dysfunctional reward processing may related abnormal decision making altered goal directed activities frequently seen patients bipolar disorder
total baroreflex arc openloop system relating carotid sinus pressure csp arterial pressure nonlinear dynamics system recently characterized first gaussian white noise csp stimulation employed open loop conditions normotensive hypertensive rats sectioned vagal aortic depressor nerves nonparametric system identification applied measured csp establish second order nonlinear uryson model aim study assess importance higher order nonlinear dynamics via development evaluation third order nonlinear model total arc using experimental data third order volterra uryson models developed employing nonparametric parametric identification methods values predicted best third order volterra model measured response gaussian white noise csp utilized developing model normotensive hypertensive rats respectively analogous values best third order uryson model values statistically different corresponding values previously established second order uryson model furthermore none third order models predicted well known nonlinear behaviors including thresholding saturation better second order uryson model additional experiments suggested unexplained variance partly due higher brain center activity conclusion second order uryson model sufficed represent sympathetically mediated total arc employed experimental conditions
indoor air quality affected indoor materials carpets may act sources sinks gas phase air pollutants heterogeneous reactions ozone carpets may result potentially harmful products study indoor residential carpets varying fiber types tested evaluate ability remove ozone assess role production carbonyls exposed elevated levels ozone tests conducted six types new unused carpets two sets experiments conducted first measured ozone removal ozone deposition velocities second measured primary carbonyl production secondary production result exposure ozone tests conducted using glass chambers volume air exchange rates tests ozone removal tests show conditions tested polyester carpet sample lowest ozone removal wool carpet greatest ozone removal carpet samples showed higher secondary primary carbonyl emissions carpets containing polypropylene fibers notable exception carpets polyester fibers highest primary secondary emissions formaldehyde among samples tested difficult make blanket conclusions relative air quality merits various carpet fiber options clear ozone removal percentages emissions volatile organic compounds vary drastically function fiber type elsevier ltd rights reserved
paper proposes computationally efficient novel superior nonlinear controller existing trajectory orientation control problem omnidirectional robot odr first position orientation pose estimation robot obtained utilizing kinematic relationships odr multi sensor fusion techniques dynamic relationships robot used form state space representation nonlinear state space representation nlssr linearized identifying controlling nonlinearity causing states linearized nlssr utilized derive state feedback controller proportional derivative integral pid controller carry tracking task performances derived controllers evaluated simulation level comparing standard nonlinear controller two proposed controllers best performing state feedback based controller able successfully implemented low cost hardware platform due computational efficiency
background individuals prader willi syndrome pws commonly show debilitating resistance change linked cognitive deficits task switching anecdotal reports suggest exposure flexibility routines development may beneficial limiting subsequent resistance change people pws consistent beneficial role exposure development task switching highlighted typical children aim investigate development resistance change individuals pws hypothesise exposure increased rigidity routines associated increased subsequent resistance change methods author compiled informant report interview two previously validated questionnaires administered caregivers individuals pws years interview examined rigidity routines resistance change across life stages defined easily distinguishable events school primary school secondary school school currently using open ended structured yes point likert questions open ended data coded using author compiled system responses two additional informants data questionnaires used assess inter informant reliability concurrent validity structured questions results validity interview supported acceptable inter rater reliability open ended coding system inter informant reliability internal consistency concurrent validity structured questions descriptive analyses ratings behaviour change showed pattern increasing resistance change life course four oldest individuals exposed substantial rigidity routines primary school furthermore one individual currently primary school exposed little rigidity routines primary school showed decrease resistance change entering primary school open ended data showed individuals currently evidencing little resistance change exposed parent self imposed flexibility routines currently evidencing substantial resistance change however correlational analyses rigidity resistance change ratings highlighted possibility rigidity primary school relevant developing resistance change finally open ended data emphasised important beneficial role rigidity routines limiting current challenging behaviour individuals high resistance change conclusion task switching appears evidence period high developmental sensitivity early primary school years propose period may represent critical time increasing flexibility routines children pws could limit development resistance change however careful balance would need struck given apparent benefit rigid routines current behaviour work area much needed
diurnal temperature range dtr temperature change neighboring days tcn important meteorological indicators closely associated global climate change however date studies addressing impacts dtr tcn emergency hospital admissions schizophrenia conducted time series analysis assess relationship temperature variability daily schizophrenia onset hefei inland city southeast china daily meteorological data emergency hospital admissions schizophrenia hefei collected stratifying season birth poisson generalized linear regression combined distributed lag nonlinear model dlnm used examine relationship temperature variability schizophrenia adjusting long term trend seasonality mean temperature relative humidity analysis revealed extreme temperature variability may increase risk schizophrenia onset among patients born spring association found patients born summer autumn patients born spring relative risks extremely high dtr comparing percentiles reference degrees day lag confidence interval respectively tcn effects comparing percentile reference degrees significantly associated emergency hospital admissions schizophrenia relative risk study suggested exposure extreme temperature variability short term may trigger later days schizophrenia onset patients born spring may important implications developing intervention strategies prevent large temperature variability exposure
turbocompounding important technique recover waste heat engine exhaust reduce emission paper presents parametric study turbocompound diesel engine based analytical model analytical model developed investigate influence system parameters engine fuel consumption model based thermodynamics knowledge empirical models consider impacts parameter independently effects turbine efficiency back pressure exhaust temperature pressure ratio engine speed recovery energy pumping loss engine fuel reductions studied results show turbine efficiency exhaust temperature back pressure great influence fuel reduction optimal power turbine expansion ratio however engine operation speed little impact fuel savings obtained turbocompounding interaction mechanism recovery power engine pumping loss presented paper due nonlinear characteristic turbine power optimum value expansion ratio achieve largest power gain end fuel saving potential high performance turbocompound engine requirements proposed paper elsevier ltd rights reserved
background data centralised population based statutory cancer registries generally considered gold standard confirming incident cases cancer available current information needed hospital routinely collected population level data may feasible alternative sources aimed determine validity various methods using routinely collected administrative health data ascertaining incident cases colorectal lung cancer participants study new south wales nsw australia methods participants study recruited ascertainment incident colorectal lung cancers assessed using diagnosis treatment records linked administrative health datasets hospital emergency department medicare pharmaceutical claims death records compared ascertainment via nsw cancer registry nswcr gold standard period data sources available participants results total colorectal lung cancers recorded study participants nswcr period diagnosis primary cancer recorded statewide admitted patient data collection identified majority nswcr colorectal lung cancers sensitivities positive predictive values ppv colorectal cancer lung cancer respectively using additional information lung cancer deaths death records increased sensitivity ppv lung cancer improve ascertainment colorectal cancers hospital procedure codes colorectal cancer surgery identified cases sensitivity ppv individual indicator sensitivity ppv either cancer type combination indicators increased sensitivity ppv achieved using hospital cancer diagnosis data specificities close confidence intervals sensitivity ppv generally conclusions nsw identifying new cases colorectal lung cancer administrative health datasets hospital records feasible alternative cancer registry data available however strengths limitations different data sources borne mind
overcome productivity challenges encountered construction projects electrical contractors often apply reactive measures overtime shiftwork paper recommends electrical contractors use prefabrication prefab proactive measure enhance projects performance current advancements information technology made feasible contractors adopt nonconventional construction methods incorporate preplanned preassembled components within projects limited information available current state prefab use electrical construction industry qualitative data electrical contractors united states canada collected qualitative data analyzed understand impact prefab use project performance perceived electrical contractors examined data revealed prefab use significantly increased last decade electrical contractors perceive offers competitive advantage market prefab use enables contractors reduce labor wages expedite construction process performing activities parallel findings within paper indicate prefab widely used multiple electrical activities implementation often results cost schedule savings increased labor efficiency addition found prefab use usually results project quality improvements finally future trends indicate prefab users planning invest effort improving prefab practices within companies developing training programs personnel establishing protocols working suppliers vendors american society civil engineers
incidence invasive fungal disease ifd rising treatment paediatric haematology oncology patients yet standardised review aimed critically appraise analyse clinical practice guidelines cpgs available paediatric ifd electronic searches medline medline process non indexed citations guidelines international network gin google performed combined fungal disease fung antifung candida aspergill prophylaxis treatment prophyl therap treatment guidelines assessed using agree tool recommendations relating prophylaxis empirical treatment specific therapy extracted nineteen guidelines met inclusion criteria agree scores rigour development domain ranged median interquartile range fluconazole recommended antifungal prophylaxis nine included guidelines recommended specific drug liposomal amphotericin recommended five guidelines giving empirical therapy recommendations specific therapy recommendations given oral genital candidiasis invasive candida infection invasive aspergillosis mould infections many areas recommendations clear appropriate practice clarity required particularly relating decision discontinue empirical antifungal treatment relative benefits empiric pre emptive strategies risk stratification future cpgs could consider working published guideline production methodologies sharing summaries evidence appraisal reduce duplication effort improving quality efficiency cpgs area
edible coatings ecs based chitosan pullulan linseed nopal cactus aloe mucilage applied layer layer technique preserve quality prolong shelf life fresh cut pineapple pineapples washed disinfected dried cut side cubes fresh cut fruit coated dipping using four treatments packed polyethylene terephthalate containers stored degrees uncoated fruit used control application layer layer ecs decreased weight loss pineapple softening retarded fall total soluble solids content color effective delaying microbiological analyses demonstrated effectiveness layer layer ecs spoilage microorganisms monocytogenes typhi effective controlling microbial levels sensory analysis demonstrated layer layer ecs helped preserve quality properties color odor flavor texture overall acceptance conclusion layer layer ecs based improved quality prolonged shelf life fresh cut pineapple six days compared control elsevier rights reserved
study examined feasibility using quantitation augment interpretation florbetapir pet amyloid imaging total physician readers trained quantitation florbetapir pet images principles using quantitation augment visual read day readers completed visual read scans autopsy verified patients seeking diagnosis day readers reinterpreted scans augmenting interpretation quantitation visq method using one three commercial software packages subset readers reinterpreted scans day based visual read visvis control autopsy verified scans neuropathologist modified cerad plaque score used truth standard interpretation accuracy autopsy truth standard available scans patients seeking diagnosis majority visq interpretation three readers best accuracy interpreting autopsy verified scans used reference standard day visual read accuracy high autopsy verified scans scans patients seeking diagnosis accuracy improved visual read visq read day accuracy interpreting autopsy verified scans also increased first second visual read visvis group however agreement reference standard best readers scans patients seeking diagnosis improve second visual read cohort visq group significantly improved relative visvis group change results indicate augmentation visual interpretation florbetapir pet amyloid images quantitative information obtained using commercially available software packages reduce accuracy readers already performing average accuracy visual read may improve accuracy confidence readers clinically relevant cases
cell proliferation transformation epithelial mesenchymal transition emt key processes involved development idiopathic pulmonary fibrosis ipf study investigated regulatory factors signaling pathways mediate emt human type alveolar epithelial cell line cells cultured rpmi medium allocated following four groups blank control group treated transforming growth factor beta tgf beta tgf beta calpain inhibitor examined cadherin cad alpha smooth muscle actin alpha sma calpain mrna transcript protein expression levels four groups performing pcr western blot analyses results indicated tgf beta treatment significantly downregulated cad upregulated alpha sma expression compared blank control group tgf beta also enhanced calpain expression compared blank control group contrast treatment calpain inhibitor increased cad expression decreased alpha sma expression furthermore treatment antagonized tgf beta mediated increase akt phospho akt epithelial cells however tgf beta induced etm correlated erk jnk signaling pathways combined results indicate calpain could regulate emt tgf beta treated epithelial cells via pik akt signaling pathway
article discusses automated test complex based pxi devices basis monitoring parameters functioning integrated opamp radiation experiments need measurements input signals high accuracy support specified
two dimensional finite element analysis used investigate performance seawall construction weak subgrade soil using artificial base layer material consisted cemented sand cushion comprising geosynthetics materials two types base layer materials pure sand cemented sand comprising husk rich ash two types geosynthetics materials geogrid geotextile used constitutive models used represent different materials numerical analysis competence two dimensional numerical analysis compared experimental results numerical results showed superior harmony experimental results finite element analysis model proved great tool determine parameters difficult measure laboratory experiments addition finite element analysis benefit cost time saving compared experimental investigation work numerical results showed strain induced geosynthetics eliminated beyond distance approximately equal six times footing width
little information available actually happens software vulnerability detected performed empirical study reporters three prominent security vulnerabilities buffer overflow sql injection cross site scripting vulnerabilities goal understand methods tools used discovery whether community developers exploring one security vulnerability differs approach another community developers exploring different vulnerability reporters featured securityfocus repository twelve month periods vulnerability collected responses found communities differ based security vulnerability target within specific community reporters follow similar approaches also found serious problem vulnerability reporting process common communities reporters especially experienced ones favor full disclosure collaborate vendors vulnerable software think public disclosure sometimes supported detailed exploit put pressure vendors fix vulnerabilities practice vulnerabilities reported vendors less likely fixed first study vulnerability repositories targets reporters common security vulnerabilities thus concentrating people involved process previous works overlooked rich information source results valuable beginners exploring detect report security vulnerabilities tool vendors researchers exploring automate fix process
background abdominal pain cramping discomfort apcd experienced adults europe objective assess impact apcd quality life qol investigate effectiveness tolerability impact qol hyoscine butylbromide hbb buscopan compared stw iberogast analgesics women apcd methods internet based observational pilot study conducted germany women predominantly used hbb stw analgesics per treatment treat apcd online survey included questions qol effectiveness tolerability results total completed questionnaires evaluated apcd major impact qol women reporting daily activities disrupted least sometimes least often aspects qol quality work eating habits social activities also affected women taking medication choice women hbb group reported could often often continue daily activities compared stw analgesic groups respectively comparisons hbb perceived best solution overcome apcd symptoms often often women stw analgesics comparisons conclusion women apcd impaired qol treatments considered effective majority participants compared stw analgesics hbb reported facilitate return daily activities frequently
human fungal pathogens cause million infections per year major drivers morbidity mortality cryptococcus neoformans candida albicans two common fungal pathogens humans together accounting staggering million infections annually high mortality rates patients dysfunctional immune systems individuals hiv aids particularly susceptible fungal infections unfortunately relatively antifungal drugs currently available fungi frequently develop resistance complicating treatment approaches study screened pathogen box chemical library medicines malaria venture switzerland effort identify novel antifungal compounds approach led discovery novel highly potent antifungal agent activity neoformans albicans initial study mechanism action suggested novel compound prevents fungal proliferation targeting ability neoformans withstand stress plasma membrane cell wall compound previously shown low toxicity mammalian cells propose represents attractive lead compound antifungal drug development importance cryptococcus neoformans candida albicans two major human fungal pathogens together account million infections annually high mortality rates fungi often infect immunocompromised individuals hiv aids patients effort identify novel drugs antifungal activity screened pathogen box compounds anticryptococcal anticandidal activities approach led discovery promising lead compound mmv strong antifungal potency nutrient limited conditions
interpretation regression models results often benefit generation nomograms user friendly graphical devices especially useful assisting decision making processes however case multinomial regression models whenever categorical responses two classes involved nomograms drawn conventional way difficulty managing interpreting outcome could often result limitation use multinomial regression decision making support present paper illustrate derivation non conventional nomogram multinomial regression models intended overcome issue although may appear less straightforward first sight proposed methodology allows easy interpretation results multinomial regression models makes accessible clinicians general practitioners development prediction model based multinomial logistic regression pertinent graphical tool illustrated means example involving prediction extent liver fibrosis hepatitis patients routinely available markers
gearless one motor concept contra rotating fans presented article rotors mounted electric motor using one shaft coupling rotors realised utilising conservation angular momentum contra rotating fans diameter design speed min first stage min second stage designed investigated series experiments institute air handling refrigeration dresden performance map particle image velocimetry measurements conducted numerical models quasi steady state transient simulations implemented carried institute mechanics fluid dynamics results show good agreement quasi steady transient simulations experiment however close stall time resolved simulations show superior performance compared steady state computations
purposeto understand vouchers non vha care vha enrolled veterans might affect rural enrollees determined much enrollees use vha non vha inpatient care whether use varies substantially rural urban residents depending state residence methodsfor veterans listed vha enrollment file living arizona iowa louisiana tennessee florida south carolina pennsylvania new york merged administrative discharge data vha hospitalizations non vha hospitalizations listed state health department hospital association databases within states rural urban residents ruca defined compared vha non vha hospitalization rates overall major diagnostic categories findingsnon vha hospital use much greater vha use though also variable across states states higher proportions urban enrollees use non vha hospitals lower small isolated rural town residents urban residents rural states greater rural enrollees also used vha hospitals urban enrollees lived south used vha hospitals less states findings consistent across principal diagnoses except every state rural veterans hospitalized less often mental disorders respiratory diseases logistic regressions controlling several covariates consistently showed rural enrollees relied vha hospitals urban enrollees vouchers would likely increase non vha use states greater rural populations conclusionsvouchers non vha inpatient care might greater impact rural states
aims develop assess structure test retest reliability discriminative validity self report questionnaire university south australia urinary sensation assessment usa assess multiple dimensions urgency sensation methods usa designed tested two prospective observational studies participants english speaking australians aged without overactive bladder oab determined oab awareness tool recruited via health recreation centers study exploratory factor analysis determined usa structure subscales study confirmatory factor analysis reassessed structure mann whitney tests determined discriminative validity oab non oab subscale total scores cohen effect sizes thirty three individuals completed usa twice intraclass correlation coefficients iccs wilcoxon signed rank tests assessed test retest reliability resultsquestionnaires returned eligible participants study study exploratory factor analysis revealed three subscales urgency affective fullness confirmatory factor analysis supported subscales subscale total scores significantly different groups without oab cohen effect sizes total score urgency subscale affective fullness total subscales scores demonstrated test retest reliability iccs cis conclusions usa assesses multiple dimensions urgency sensation reliable week period discriminates older adults without oab validation required conditions overactive bladder wiley periodicals inc
currently teachers play increasingly important role informants context psychological diagnostic processes still uncertain far rater agreement students teachers well agreement different self report scales affected specific characteristics students age gender sample students mean age age span years tested characteristics impact amount agreement teachers students ratings concerning social learning behavior regression model secondary tested agreement different self report scales regarding social learning behavior well prosocial behavior psychological stress effected student age gender appears rater agreements girls teachers larger boys teachers possible explanations results discussed
purpose introduce simple analytical formula estimating single double echo steady state dess scan methods extended phase graph epg modeling used develop straightforward linear approximation relationship two dess signals enabling accurate estimation one dess scan simulations performed demonstrate cancellation different echo pathways validate simple model resulting analytic formula compared previous methods estimation using dess fast spin echo scans agar phantoms knee cartilage three volunteers three patients dess approach allows mapping fat suppression scan times min results simulations demonstrated model approximates true signal well within assumed estimation error shown less typical scans inherent residual error model demonstrated small due signal decay opposing signal contributions estimated linear relationship agrees well reference scans phantoms vivo method resulted less underestimation previous single scan approaches processing times times faster using numerical fit conclusion simplified relationship two dess signals allows rapid quantification dess accurate yet also simple simplicity method allows immediate estimation cartilage mri examination elsevier inc rights reserved
work proposes procedure accurately identifying instantaneous modal parameters linear time varying system using time varying autoregressive exogenous input tvarx model continuous cauchy wavelet transform ccwt appropriate tvarx model established using velocity displacement responses system consideration time varying coefficients tvarx expanded piecewise polynomial functions ccwts various scale parameters applied tvarx model evaluate instantaneous modal parameters different modes ccwts velocity displacement responses analytically obtained ccwt measured acceleration responses effectiveness accuracy proposed procedure validated numerical simulations single multiple degrees freedom systems periodically varying sharply varying stiffness damping coefficients effects noise cauchy wavelet function order polynomial evaluation modal parameters explored processing numerically simulated acceleration responses systems single degree freedom subjected base excitation finally proposed procedure adopted determine modal parameters five story symmetric steel frame measured acceleration responses shaking table test measured strains reveal yielding columns first story variations identified instantaneous natural frequencies modal damping ratios time consistent physical phenomena observed measured strains base excitation acceleration elsevier ltd rights reserved
increasing demand energy advances exploration development technologies attention devoted exploration development deep oil gas reservoirs nanpu sag contains huge reserves deep oil gas reservoirs promising area paper physico chemical mechanical properties hard brittle shales shahejie formation nanpu sag bohai bay basin northern china investigated using variety methods including ray diffraction analysis cation exchange capacity cec analysis contact angle measurements scanning electron microscope observations immersion experiments ultrasonic testing mechanical testing effects physico chemical properties shales wellbore instability observed effects hydration shales wellbore instability also examined results show major mineral constituents investigated shales quartz clay minerals clay mineral contents range quartz contents range clay minerals include montmorillonite large amounts mixed layer illite smectite observed cec values shales range mmol indicating shales partly hydrated wettability shales strongly water wetted indicating water would enter shales due capillary effect hydration hard brittle shales generate cracks leading changes microstructure increases acoustic value could generate damage shales reduce strength increasing hydration time shale hydration effect gradually becomes stronger causing increase range acoustic travel time decreases ranges cohesion internal friction angles hard brittle shales nanpu sag drilling fluid systems aim enhance sealing ability decrease drilling fluid filter loss increase amount clay hydration inhibitor used
recently new cmos current mode pseudo exponential function generator circuit reported popa entire analysis exponential function generator circuit given popa paper based current squaring circuit module comment paper show current squarer circuit presented popa paper work current squarer consequently pseudo exponential generator also work described popa paper present detailed mathematical analysis paper derive actual operation simulation results circuit module using mentor graphics custom design tool set tsmc cmos process also shown paper simulation results match behavior predicted mathematical analysis
objectives monozygotic twins near identical genotypes discordance complex diseases represent exceptional resource ascertain disease etiology strategy particularly effective availability high resolution complete individual genome sequencing challenge using effective approaches identify relevant differences may cause contribute toward disease discordance participants methods study carried varscan bioinformatic analysis pathway analysis whole genome sequences two sets monozygotic twins results variants identified present affected twin found unaffected twin variations expected novo originate independent development twins may make discordant disease genes novo variants identified experiment compatible involvement schizophrenia analysis variants identified pathways including glutamate receptor signaling implicated neurodevelopmental disease conclusion results support polygenic nature schizophrenia threshold model development results also show effectiveness varscan identify needle hay stack may cause schizophrenia specifically two patients offers proof principle assessment genetic etiology complex disorders discordance monozygotic twins established phenomenon copyright wolters kluwer health inc rights reserved
matrix metalloproteinases mmps family endopeptidases also known gelatinases reported affect acquisition cell proliferative cell invasive metastatic phenotype several types cancer particular gelatinases mmp revealed facilitate tumor growth invasion patients colorectal cancer crc however known whether gelatinase activity mmp also elevated vietnamese patients crc activity mmp tissue samples patients crc evaluated gelatin zymography quantified using imagej association level activity mmp various clinicopathological factors analyzed chisio biopax editor software used visualize biological pathways regulating activity mmps present study noticed significantly increased activity active mmp mmp tumor tissues significantly decreased levels pro form mmp mmp tumor tissues compared adjacent tissues patients crc correlation normalized different activity mmp various clinicopathological features observed furthermore bioinformatics analysis indicated alteration activity mmp mmp may controlled biological pathways involving tissue inhibitors metalloprotease findings indicate activity gelatinases mmp affects tumor progression metastasis patients crc providing potential novel approach determining prognosis crc
bacterial colonization skin tonsil may influence clinical response patients psoriasis immunosuppressive drugs however studies investigated effects bacterial superantigens therapy patients recently combination therapy topical glucocorticoids vitamin appears effective monotherapy psoriasis evaluated suppressive effects betamethasone butyrate propionate bbp three derivatives calcipotriol maxacalcitol tacalcitol cyclosporin bbp plus concanavalin cona streptococcal pyrogenic enterotoxin spea stimulated proliferation peripheral blood mononuclear cells pbmc obtained psoriasis patients drug concentrations effecting inhibition concentration cona spea stimulated pbmc proliferation estimated cytokine levels tumor necrosis factor interferon interleukin pbmc culture supernatants measured bead array procedures suppression pbmc proliferation bbp significantly lower pbmc stimulated spea stimulated cona contrast suppressive effects calcipotriol tacalcitol increased significantly pbmc stimulated spea stimulated cona suppressive effect bbp spea stimulated pbmc proliferation improved significantly adding calcipotriol compared bbp alone cytokine levels pbmc culture supernatants significantly different cona spea stimulated pbmc calcipotriol bbp combination markedly suppressed spea stimulated pbmc proliferation spea produced colonization hemolytic streptococci may reduce efficacy bbp derivatives treatment psoriasis
computer programming process embodies creation executable computer program given computational problem analyzing task developing algorithm computes desired result due complex diverse nature programming requires certain level expertise analysis algorithms data structures mathematics formal logic well related tasks testing debugging due increasing awareness need programming exists numerous competitive programming websites students practice solve problems aim work assess performance students platforms work shall help learners self assess also aid educators evaluate progress students meet objective data collected two different competitive programming environments namely hackerearth globally accessible competitive programming website university house programming portal university based programming environment used supervised learning predict performance students datasets accuracy obtained hackerearth dataset accuracy university dataset computed apart predicting performance rigorous analyses done unearth hidden trends responsible learners programming acumen
many finite element models designed based geometric information computed tomography data validated via comparison experimental results human cadaver ossicular bones describe novel method developing analyzing biomimetic ceramic ossicles bco combination printing technology establish model bco analyzing vibration peiformance novel biomimetic ceramic ossicles bco made hydroxyapatite fabricated using printing technology vibration properties measured created model bco using computer aided design corresponds ossicular structure geometry created model human ossicles via comparison experimental simulated vibrations investigate characteristics ossicular chain model established based displacements malleus incus stapes analyzed using externally applied vibrational force
materials engineering often essential know best solvents process polymer employing methods based hansen solubility parameters effective way find work hansen solubility parameters polyether sulfone lignin bitumen calculated alternative optimization procedure shown applying evolutionary strategy hansen correlation method possible improve fitting solubility spheres compared previous calculations quality fit parameters optimized result sphere radii reduced except lignin least one solubility parameters considerably changed mpa shortcomings correlation method also pointed lack data quality evaluation set solvents uncertain character partially solving solvents least former could handled proposed parameter called fill factor wiley periodicals inc
partial wetting surfaces influence droplet movement micro nano scale contemplated many useful applications dynamics droplet usually analyzed multiphase lattice boltzmann method lbm paper influence partial wetting surface dynamics droplet systematically analyzed various cases splitting droplets due chemical gradient surface studied analyses splitting time various widths strips different weber numbers computed proposed model one tune splitting volume time carefully choosing strip width droplet position droplet spreading chemically heterogeneous surfaces shows spreading controlled parameters weber number also tuning strip width ratio transportation droplet hydrophobic surface hydrophilic surface due chemical gradient simulated analyzed using hybrid thermodynamic image processing technique results prove progress time surface free energy decreases increase spreading area finally transportation droplet microstructure gradient demonstrated model explains temporal behaviour droplet spreading recoiling translation along tracking contact angle hysteresis phenomenon elsevier rights reserved
harnessing nonlinear optical effects photonic chip scale proven useful number key applications optical communications microwave photonics mwp also benefit adoption technology creating new concept nonlinear integrated mwp look potential using nonlinear optical effects chip scale enable signal processing enhanced performance review number recent results field particular focus creation frequency agile high suppression microwave bandstop filters using chip stimulated brillouin scattering also discuss future prospect nonlinear integrated mwp enable general purpose programmable analog signal processor well compact high performance active microwave filters enhanced energy efficiency
aims determine tolerability optimal dose regimen soluble guanylate cyclase stimulator vericiguat patients chronic heart failure preserved ejection fraction hfpef methods results socrates preserved prospective randomized placebo controlled double blind phase dose finding study patients hfpef ejection fraction patients received vericiguat daily fixed doses titrated starting dose placebo weeks two primary endpoints change baseline log transformed terminal pro type natriuretic peptide probnp left atrial volume lav weeks patients women mean age years baseline atrial fibrillation randomized within weeks hospitalization outpatient treatment intravenous diuretics vericiguat placebo pooled three highest dose arms change lognt probnp vericiguat log placebo log one sided two sided change lav vericiguat placebo one sided two sided different placebo vericiguat well tolerated adverse events vericiguat arm placebo low discontinuation rates groups changes blood pressure compared placebo pre specified exploratory end point kansas city cardiomyopathy questionnaire clinical summary score improved vericiguat arm mean points median interquartile range baseline mean difference placebo points conclusion vericiguat well tolerated change probnp lav weeks compared placebo associated improvements quality life patients hfpef given encouraging results quality life effects vericiguat patients hfpef warrant study possibly higher doses longer follow additional endpoints
whether children share anticipation future benefits returned partner interesting question study year old children adult partner played sharing game children donated first partner donated afterward experiment partner resources attractive child reciprocal condition child told would recipient partner played donor non reciprocal condition however child told anonymous child would recipient partner donated results showed children shared partner knew would recipient later experiment child always recipient partner donated partner resources desirable child high value condition less desirable low value condition found children generous partner resources valued higher findings demonstrate year old preschoolers sharing choices take account anticipated reciprocity recipient suggesting either self interested tactical sharing direct reciprocity advance receiving specifically adjust sharing behavior depending whether partner potential reciprocate whether worth sharing relative value payback
context despite implementation affordable care act aca million working age americans remained uninsured vulnerable premature death poor health care access aca mandated phasing disproportionate share hospital payments supported charity care may aggravate care access residual uninsured objectives estimate excess deaths among uninsured potential aca impact basis recent cohort mortality experience hypothesized higher uninsured mortality risk available pre estimate worsening care disparities owing technology driven advances life saving care design conducted retrospective cohort study national health nutrition examination survey respondents observed estimated weighted cox proportionalmortality hazard uninsuredworking age adults adjusted demographics comorbidity lifestyle behaviors weighted mortality rates among uninsured insured within age comorbidity strata excess deaths uninsurance using institute ofmedicine methodology setting noninstitutionalized population participants adults aged years main outcome measure mortality results study eligible respondents uninsured died follow adjusted uninsured mortality hazard ratio confidence interval versus privately insured translating excess deaths among population aged years total deaths age group estimated proportion excess deaths higher pre cohort study mortality disparity increased age comorbidity conclusions findings support hypotheses indicate post aca residual excess mortality among working age adults continue excess deaths annually restoration disproportionate share hospital supports continued advocacy universal health care coverage needed reduce avoidable deaths
introduction growing exposure human skin environmental occupational hazards numerous skin care beauty products topical drugs led biomedical concern regarding sustainability cutaneous chemical defence essential protection intoxication since skin largest extra hepatic drug xenobiotic metabolising organ redox dependent metabolic pathways prevail review publications metabolic processes leading redox imbalance oxidative stress autocrine endocrine impact cutaneous drug xenobiotic metabolism scrutinised areas covered chemical photo chemical skin barriers contain metabolic redox compartments protective homeostatic functions review examine striking similarity adaptive responses exogenous chemical photo chemical stressors endogenous toxins cutaneous metabolic redox system role xenobiotics drugs phase enzymes endogenous antioxidant defence maintenance redox balance redox regulation interactions metabolic inflammatory responses skin cells skin diseases sharing metabolic redox problems contact dermatitis lupus erythematosus vitiligo expert opinion due exceptional redox dependence cutaneous metabolic pathways interaction redox active metabolites exogenous antioxidants drug xenobiotic metabolism metabolic tests topical xenobiotics drugs combined appropriate redox analyses performed human skin models
doped zinc oxide zno films successfully synthesised via sol gel method spin coating onto glass substrates followed annealing air degrees ray diffraction patterns annealed specimens exhibit well defined diffraction peaks indexed hexagonal wurtzite structure trace tin metal oxides binary zinc tin phases indicating metallic entered zno lattice form dopant concentration caused carrier concentration grain size change thus affecting infrared emissivity zno films zno film doped infrared emissivity decreased temperature increases favourable application infrared stealth technology
building materials bms major contributors indoor emission sources volatile organic compounds vocs study kinds bms including conventional green ceiling cabinetry flooring commonly used indoors tested chamber primary emissions carbonyls aldehydes ketones conventional bms green bms primary emissions btex conventional bms green bms ozone initiated molar yields carbonyls conventional bms green bms secondary emissions carbonyls conventional bms green bms green bms lower emissions conventional analogs especially wooden flooring gypsum board bms mineral content promising materials study given moderately high ozone deposition velocity generating least byproducts secondary emissions determined study demonstrate moderate indoor ozone concentrations may lead increased concentrations carbonyls especially formaldehyde acetaldehyde potentially increase adverse chronic health effects elsevier ltd rights reserved
paper presents electrical characteristics gallium nitride gan current aperture vertical electron transistor cavet using two dimensional technology computer aided design tcad simulations cavets considered alternative device due high breakdown voltage high integration density high power applications optimized design cavet focused electrical performances according different gate source length aperture length analyze parameters inducing state current threshold voltage breakdown voltage transconductance gate capacitance cut frequency maximum oscillation frequency max
antibody drug conjugates adcs selectively deliver large amounts antitumor drugs tumor tissue show significant antitumor effects wide therapeutic window developed new linker drug technology platform exatecan derivative highly potent topoisomerase inhibitor major advantages technology high homogeneous drug antibody ratio dar availability potent antitumor activity conjunction bystander killing safety concerns stable linker limiting release free drug wide application therapeutic antibodies using linker drug technology generated anti adc namely almost eight cysteine residues antibody bound drug effective trastuzumab dmi insensitive patient derived xenograft pdx models high expression also demonstrated antitumor efficacy several breast cancer pdx models low expression well tolerated rats monkeys following repeated administration results suggest may efficacious broader population positive cancer patients also confirm importance new class novel topoisomerase inhibitor based adc technology
two key issues landslide forecasting finding critical slip surface determining parameters generally issues two parts one problem solve problem new two phase search method proposed newly proposed inversion method determine critical slip surface parameters using new bionics algorithm particle swarm optimization based measured slip surface critical slip surface searching process proposed method verified using two typical numerical examples used association computer aided design australia engineering example highway landslide results indicate search critical slip surface inversion parameters performed simultaneously calculated factor safety good agreement actual scenario whereas factor safety computed basis known parameters slide body deviate physical scenario
objectives present study aimed investigating effectiveness tolerability bupropion hydrochloride extended release major depressive disorder mdd patients atypical features methods patients prescribed bupropion weeks visits screening baseline weeks primary efficacy measure change structured interview guide hamilton depression rating scale seasonal affective disorder version sigh sad baseline endpoint secondary efficacy measures included sigh sad atypical symptoms subscale clinical global impression severity cgi sheehan disability scale sds epworth sleepiness questionnaire esq response remission defined reduction sigh sad total scores respectively end treatment results ham total score reduced baseline end treatment atypical symptom subscale scores also reduced baseline end treatment end treatment subjects classified remitters responders respectively frequently reported aes headache dry mouth dizziness dyspepsia conclusions preliminary study indicates bupropion may beneficial treatment mdd atypical features adequately powered randomized double blind placebo controlled trials necessary determine results
objective compare efficacy safety extended release formulation propiverine hydrochloride formulation tolterodine tartrate patients overactive bladder oab non inferiority trial patients methods eligible patients aged years symptoms oab enrolled multicentre randomized double blind parallel group active controlled study week screening period patients randomized ratio receive either propiverine tolterodine daily week treatment period efficacy assessed using day voiding diary patient self reported assessment treatment effect safety assessment included recording adverse events laboratory test results measurement post void residual urine electrocardiograms results total patients female male included study active treatments improved variables included voiding diary patient self reported assessment change baseline number voidings per significantly greater propiverine group compared tolterodine group weeks treatment full analysis set fas significant improvements also observed change urgency incontinence episodes weeks weeks treatment comparing propiverine tolterodine treatments well tolerated similar frequency adverse drug reactions propiverine tolterodine groups fas patients treated tolterodine discontinued treatment adverse drug reactions compared propiverine conclusions propiverine confirmed effective well tolerated treatment option patients oab symptoms first head head study showed non inferiority propiverine compared tolterodine
intracranial abscess serious mortality therefore early diagnosis treatment important intracranial abscess rarely seen complication sinusitis specially children reported rarely fever headache indicate complications children
emotion regulation core developmental process related children academic success mental health small body research documented maltreated children show deficits developmental arena current study designed add limited literature emotion regulation maltreated children foster care emotion regulation tasks administered preschool foster children videotaped later coded parenting assessed via coded observations mother child interactions mothers reported experience depressive symptomatology examined relation foster parenting foster mother depression well child characteristics child welfare experiences emotion regulation specifically joy anger domains findings revealed maternal depression parental structuring significantly contributed children anger regulation regulation joy findings considered context future research respect young maltreated children foster care
study investigated extent life skills training offered middle high school students autism life skills training needs high school secondary analysis national longitudinal training study nlts data conducted study study found majority middle high school students autism received life skills training school receipt life skills training differed across students gender age diagnosis intellectual disability functional mental skills students received life skills training general education classrooms special education classrooms individual instruction community settings life skills training needed majority high school leavers autism
novel label free system sensitive fluorescent detection deoxyribonuclease dnase activity developed utilizing dna templated silver nanocluster graphene oxide dna agnc nanocomposite agnc first synthesized around rich template dna resulting dna agnc binds interaction extension dna resulting dna agnc would show quite reduced fluorescence signal fluorescence dna agncs quenched presence dnase however degrades dna strand within dna rna hybrid duplex probe employed study consequently releasing rna complementary extension dna released free rna extracts dna agnc hybridizing extension dna bound process would restore quenched fluorescence emitting highly enhanced fluorescence signal employing assay principle dnase activity reliably identified detection limit lower previous fluorescence based methods finally practical capability assay system successfully demonstrated use determine dnase activity bovine urine elsevier rights reserved
purpose work innovative rhombus briquetting mechanism model development mechanism model simulation tool transition prototype real machine design simulation working model software used working model software capable modelling motion rigid bodies may connected variety joints constraints simulation result evaluation energy consumption pressing cycles determined laboratory experiment simulation difference energy consumption results grams briquette pressing
background autism spectrum disorders asds pervasive multifactorial neurodevelopmental conditions characterized impairments social communication interaction restricted repetitive patterns behaviour interests activities treatment options ameliorate symptoms asds limited heterogeneity complicates quest personalized medicine population aim investigate baseline characteristics patients moderate response trial design features impede identification efficacious interventions asds method literature searches embase medline psycinfo identified studies qualitative assessment baseline characterization participants studies quantitative analysis moderators treatment response criteria included blinded randomized controlled trials rcts paediatric asd least participants per arm overall oral treatments including pharmacological interventions dietary supplements results random effects meta analysis participants male identified three moderators associated increase treatment response trials located europe middle east outcome measures designated primary status type outcome measure inconsistent reporting baseline symptom severity intellectual functioning prevented analysis variables qualitative synthesis baseline characteristics identified least variables age gender reported trials biological markers included six rcts conclusions trials reported adequate baseline characteristics permit detailed analysis response treatment consideration geographical location baseline severity intellectual function required ensure generalizability results use biological markers correlates asd trials remains infancy great need improve application baseline characterization incorporation biological markers correlates permit selection participants homogeneous subgroups inform response treatment asd
systemic validated model developed predict ultraviolet spectra features shock layer near space hypersonic vehicles solar blind band region computational procedures performed species thermal non equilibrium fluid mechanics finite rate chemistry radiation calculations thermal non equilibrium flow field calculated two temperature model finite volume technique verified bow shock ultra violet bsuv flight experiments absorption coefficient mixture gases evaluated line line method validated laboratory shock tube measurements using line sight los method radiation calculated three bsuv flights altitudes investigation focused level structure ultraviolet spectra radiated band system wavelengths results predicted current model show qualitative spatial agreement measured data velocity mach peak absolute intensity altitude two orders magnitude higher flight conditions spectra structures quite similar distribution different viewing angles present computational model performs well prediction ultraviolet spectra emitted shock layer contribute investigation analysis radiative features hypersonic vehicles near space chinese society aeronautics astronautics production hosting elsevier ltd
study examines whether mismatch positions individuals hold different status hierarchies results symptoms stress prior research focused inconsistencies socioeconomic status dimensions education income find significant relation status inconsistency stress paper build research role differentiation propose study effect inconsistencies instrumental status expressive status group contexts hypothesize people inconsistency status dimensions experience feelings uncertainty frustration interactions others manifests stress related symptoms test hypothesis data collected medium sized dutch childcare organization polynomial regression analysis visualized response surface plots suggests status inconsistent employees report higher levels stress elsevier inc rights reserved
primary psychopathy traits correlate sexual coercion mate poaching lack relationship exclusivity reflecting instrumental use others fulfill personal desires sexual behaviors also explained sexual thrill seeking impulsivity striving relationship intimacy fear abandonment given impulsive thrill seeking rejection avoidance related secondary psychopathy borderline personality disorder respectively study first consider independent effects psychopathic traits versus borderline personality disorder traits sexual behaviors non clinical mixed sex university student sample results broadly support sexual behavior dissociation hypothesis unique relationships identified primary psychopathy traits use non violent sexual coercive tactics women reduced relationship exclusivity terms increased likelihood mate poaching whereas borderline personality disorder traits showed independent relationship increased likelihood sexual coercion men lost partner poaching opposite experiences mate poaching along unique association psychologically manipulative sexual coercion primary psychopathy considered terms fit clinical equivalents elsevier ltd rights reserved
objective assess prospectively effectiveness lacosamide lcm added levetiracetam lev titration concomitant sodium channel blocker scb among patients focal epilepsy adequately controlled lev scb methods open label trial lcm initiated day titrated day weeks scb titration started lcm dose reached day patients remained stable lcm lev doses weeks maintenance week treatment period primary outcome retention rate lcm results due recruitment challenges fewer planned patients participated trial resulting trial underpowered overall patients mean age years started completed trial frequently used scbs lamotrigine carbamazepine oxcarbazepine eighty four patients adhered protocol discontinued scb cross titration insufficient evidence patients retention rate patients evidence scb discontinuation seizure freedom patients completing maintenance discontinuation due adverse events lack efficacy occurred primarily cross titration frequently reported adverse events treatment dizziness headache fatigue conclusions patients uncontrolled seizures lev scb lcm lev combination appeared effective well tolerated cross titration schedule flexible lcm titration concomitant scb titration stable background lev could present feasible practical approach initiating lcm minimizing pharmacodynamic interactions scb
mobile cloud computing mcc emerging paradigm transparently provide support demanding tasks resource constrained mobile devices relying integration remote cloud services research field tackling multiple conceptual technical challenges offload hindering full realization mcc networked autonomic machine nam framework tool supports facilitates design networks hardware software autonomic entities providing consuming services resources framework applied particular mcc scenarios paper focus nam features related key aspects mcc particular concerning code mobility capabilities autonomic offloading strategies first contribution definition set high level actions supporting mcc second contribution proposal formal semantics actions provides core nam features precise formal characterization thus third contribution development nam conceptual framework particular partial engineering related java middleware show effectiveness revised middleware discussing implementation global ambient intelligence case study
background authors conducted systematic review literature determine treatment effects invasalign orthodontic system align technology santa clara calif types studies reviewed authors reviewedclinical trials assessed invisalign treatment effects nongrowing patients consider trials involving surgical simultaneous fixed removable orthodontic treatment interventions results authors searched electronic databases pubmed medline medline process non indexed citations evidence based medicine reviews embase excerpta medica thomsen isi web science lilacs help senior health sciences librarian used invisalign sole search term documents appeared combined search thereafter used clinical trials humans invisalign treatment effects abstract selection criteria two published articles met inlclusion criteria though reading actual articles authors determined adequately evaluate invisalign treatment effects articles identified methodological issues clinical implications inadequately designed studies authors found represented lower level evidence level therefore authors found strong conclusions could made regarding treatment effects invisalign appliances future prospective randomized clinical trials required support sound scientific evidence claims invisalign treatment effects clinicians rely theirinvisalign clinical experience opiniomns experts limited published evidence using invisalign appliances
computer systems authenticate users time initial login lead security concerns continuous authentication explored approach alleviating concerns previous methods continuous authentication primarily use biometrics fingerprint face recognition behaviometrics key stroke patterns describe caba novel continuous authentication system inspired leverages emergence sensors pervasive continuous health monitoring caba authenticates users based bioaura ensemble biomedical signal streams collected continuously non invasively using wearable medical devices signal may highly discriminative demonstrate collection signals along robust machine learning provide high accuracy levels demonstrate feasibility caba analysis traces mimic dataset propose various applications caba describe extended user identification adaptive access control authorization finally discuss possible attacks proposed scheme suggest corresponding countermeasures
general assumption male batterers clinical samples mostly insecurely attached compared non batterers recently large group found batterers clinical sample whose main attachment style secure previous studies examined specifically securely attached batterer aim present study test whether antisocial personality disorder aspd narcissistic personality disorder npd borderline personality disorder bpd traits may related battering among securely attached individuals twenty seven securely attached batterers insecurely attached batterers securely attached controls insecurely attached controls lived netherlands filled self report measures personality disorder traits antisocial narcissism borderline attachment avoidant anxious results showed aspd traits explained variance battering securely attached individuals npd bpd traits related battering among securely attached individuals npd bpd traits entered alone equation
paper mainly reviews history construction underground utility tunnel china points existing problems based analysis several construction cases practical experience large scale promotion construction urban underground utility tunnels china given decision making planning construction management aspects may helpful development underground utility tunnels countries published elsevier ltd
new voltage mode multi input single output miso type biquad proposed proposed configuration employs one voltage differencing transconductance amplifier vdta active element two capacitors grounded resistor configuration realizes five filter functions low pass high pass band pass notch pass without matching condition natural frequency omega bandwidth independently tunable workability proposed configuration verified using spice simulation tsmc cmos process parameters
view practical application problems traditional parallel processing technology existing processing massive data using powerful cloud computing power efficient massive data processing method combined advantages real time access relational database based hadoop distributed computing framework using map reduce framework author designs implements massive data processing platform based cloud computing practice proved system superior traditional parallel processing technology computing power stability scalability aspects effectively solve large concurrent access massive data many industries institutions rapid batch processing large data sets large medium sized databases data warehouses wide range application requirements realize fast interactive batch processing massive data increasingly prominent problem management information system also key problem solved engineering data sets traditional data platform based parallel processing unable meet actual requirements massive data processing architecture massive information technology urgently needs dynamic scalable storage calculation model order achieve rapid response mechanism large scale database data query analysis extraction updating batch processing processes facing serious practical problems first traditional database complex query time long faced query task large amount data even complete second system faced data task concurrency performance system drastically reduced third expandability traditional database poor additionally expandable hardware effectively improve performances system processing fourth cost massive data retrieval processing high high maintenance cost researches massive data processing technology time high efficiency effectively improve application performances computer system provide better social basic services promote growth economic efficiency new business computing model based internet cloud computing provides flexible computing capability efficient method processing massive data author paper applies cloud computing massive data processing relational database designs builds massive data processing platform based cloud computing provides new method solution processing massive data relational database
paper presents new model free adaptive fractional order control approach linear time varying systems online algorithm proposed determine frequency characteristics using selective filtering design fractional pid controller based numerical optimization frequency domain criterion system parameters time varying controller updated keep desired performances main advantage proposed approach controller design depends measured input output signals process effectiveness proposed method assessed numerical example isa published elsevier ltd rights reserved
study aims clarifying detailed morphological topographical changes thoracic part sympathetic trunk sheep fetal development bilateral micro dissection thoracic sympathetic trunk performed sheep fetuses aged weeks males females stereomicroscope cervicothoracic ganglion ctg observed sides composed caudal cervical first thoracic ganglia sides caudal cervical first two thoracic ganglia sides presence two last thoracic ganglia constant influence sex side body ages fetus morphology topography thoracic sympathetic trunk sheep identified spite differences morphology topography thoracic sympathetic trunk early late fetal developments morphology topography older fetal thoracic sympathetic trunk tended similar adult sheep comprehend comparative morphology fetal thoracic sympathetic trunk completely results compared previous studies consequently differences similarities composition position ctg presence single caudal cervical ganglion without fusion thoracic ganglia absence thoracic ganglia presence splitting interganglionic branch found among sheep pig human fetuses therefore sheep might appropriate animal model applied human sympathetic nervous system elsevier rights reserved
unobvious dead lock problems caused inappropriate acquiring releasing resources among current transactions first paper analyzes resource allocation problem caused inappropriate usage synchronization mechanism provides several ways resolve problem different points ways provide directions computer programmer avoid resource allocation problem
nicotine abuse associated variety diseases including arrhythmias often atrial fibrillation altered inward rectifier potassium currents including acetylcholine sensitive current ach known related pathogenesis since relevant data missing aimed investigate ach changes clinically relevant concentrations nicotine experiments performed whole cell patch clamp technique degrees isolated rat atrial myocytes nicotine applied following concentrations ethanol nicotine significantly activated constitutively active component ach maximum effect increase similar effect observed changes nicotine negligible average coapplication nicotine ethanol also known activate current show cumulative effect case acetylcholine induced component ach dual effect nicotine correlation current magnitude control apparent current increased nicotine cells showing small current control vice versa effect nicotine acetylcholine induced component ach significantly different conclude nicotine clinically relevant concentrations significantly increased constitutively active component ach showed dual effect acetylcholine induced component similarly ethanol synchronous application nicotine ethanol cause additive effect
study reliable broadcast problem incomplete networks byzantine adversary examine problem locally bounded adversary model koo proceedings annual acm symposium principles distributed computing podc john newfoundland canada july acm new york general adversary model hirt maurer proceedings annual acm symposium principles distributed computing podc santa barbara california usa august acm new york explore tradeoff level topology knowledge solvability problem order explore tradeoff introduce partial knowledge model captures situation player arbitrary topology knowledge refine local pair cut technique pelc peleg inf process lett order obtain impossibility results every level topology knowledge type corruption distribution positive side devise protocols match obtained bounds thus exactly characterize classes graphs reliable broadcast possible among others show koo certified propagation algorithm cpa unique locally bounded adversaries hoc networks among safe algorithms algorithms never cause node decide incorrect value means cpa tolerate many local corruptions safe algorithm settles open question posed pelc peleg also provide adaptation cpa achieving reliable broadcast general adversaries prove algorithm unique model best knowledge first optimal algorithm reliable broadcast generic topology hoc networks general adversaries
describe leading hypotheses surrounding pathophysiology overactive bladder oab well describe mechanisms action current treatment options oab two main underlying mechanisms oab mechanisms increased sensory afferent activity mechanisms abnormal management afferent signals former category increased afferent activity thought related either abnormalities urothelium receptor function neurotransmitter release urothelium based hypothesis abnormalities myocyte excitability myogenic hypothesis latter category oab thought related dysregulation handling afferent signals neurogenic hypothesis oab complex multifactorial etiology research undertaken better characterize pathophysiology disorder targeted treatments developed
significant challenge fitting metamodels large scale simulations sufficient accuracy computational time required rigorous statistical validation paper addresses statistical computation issues associated bootstrap modified press statistic yield key metrics error measurements metamodelling validation experimentation performed different programming languages namely matlab python implemented different computing architectures including traditional multicore personal computers high power clusters parallel computing capabilities study yields insight effect programming languages computing architecture computational time simulation metamodel validation experimentation performed across two scenarios varying complexity
identifying key factors influence commercial buildings decision obtain voluntary green certificates essential building sustainability enhancement using commercial buildings state new york multinomial logit nested logit models demonstrate significant correlation characteristics commercial buildings square footage lot size years built green certification interestingly commercial building occupied owner likelihood green certification actually smaller finding confirms ongoing energy savings heavily discounted deciding whether incur upfront cost green certification also suggests rental premium enjoyed green buildings likely greater terms present value expected operating cost savings another explanation could investor owners must operate competitive market tenants owner occupiers operate competitive market need obtain green certificates attract tenants consequently policymakers building owners plan rent commercial property space early targets promote green certification
background investigate expression clinical relevance src homology region domain containing phosphatase shp suppressor cytokine signaling socs acute leukemia patients methods enrolled patients divided three groups newly diagnosed relapsed complete remission healthy donors also included control group study semi quantitative reverse transcription polymerase chain reaction pcr performed measure messenger rna mrna expression shp socs statistical analysis conducted analyze correlation mrna levels shp socs patient outcomes results mrna expression shp significantly lower patients healthy donors newly diagnosed relapsed patients lower mrna levels shp patients contrast socs mrna expression significantly higher newly diagnosed relapsed patients patients well healthy donors however mrna levels shp socs positively correlated patient remission chemotherapy induced remission rate higher patients detectable shp socs expression patients undetectable shp socs expression furthermore patients detectable shp mrna expression lower incidence rate invasive fungal infection conclusion results suggest expression patterns shp socs differ patients despite difference expression shp socs associated favorable outcomes suggesting anticancer property two genes
objective thyroid hormones direct indirect effects thermogenesis modulating vascular smooth muscle cell proliferation however influence subtle changes thyroid hormones coronary atherosclerosis remains matter speculation smooth muscle cells play crucial role pathogenesis stent restenosis isr however relationship free thyroxine isr studied present study aimed assess role preprocedural serum level development isr patients undergoing coronary bare metal stent bms implantation materials methods enrolled analyzed clinical biochemical angiographic data consecutive patients without history primary thyroid disease mean age years male patients undergone bms implantation control coronary angiography owing stable unstable angina pectoris patients divided tertiles based preprocedural serum levels results isr observed patients lowest tertile patients second tertile patients highest tertile sensitivity specificity auc predicting isr conclusion higher preprocedural serum powerful independent predictor bms restenosis patients stable unstable angina pectoris
multifunctional control strategy single phase asymmetrical cascaded bridge multilevel inverter achmi suitable microgrid systems nonlinear loads presented primary advantage achmi produce staircase output voltage low harmonic content utilizing unequal voltages individual bridge cells grid connected mode operation control strategy theachmiis based conservative power theory providing selective disturbing current compensation besides injecting available energy autonomous mode operation two different control methods along damping resistor filter circuit developed regulation achmi instantaneous output voltage variety load conditions first method single loop voltage control scheme without need current measurement second one multiloop voltage control scheme load current feedforward compensation strategy preservation grid connected current control scheme steady state response stability voltage control schemes analyzed based application requirement control schemes implemented individually effectiveness control strategy experimentally verified using hardware loop setup control algorithm implemented tmsf dsp microcontroller
primary goal current study examine cultural differences chinese adolescents parents perceptions evaluations adolescent misconduct behaviors total chinese adolescents ages years parents participated study participant generated adolescent misconduct behaviors rated misconduct behavior degree wrongness misconduct behaviors coded categories across three themes moral offenses drugs conventions results revealed significant cultural differences number adolescent misconduct behaviors example united states generated misconduct behaviors weapon offenses drug use china cultural differences complicated interaction culture generation chinese adolescents likely adolescents use categories school home social conventional violations considered adolescent misconduct behaviors wrong however parents considered adolescent misconduct behaviors categories wrong chinese parents
objectives seasonal affective disorder sad subtype recurrent unipolar bipolar depressive disorder higher prevalence winter summer biological underpinnings sad far poorly understood studies examining sad found disturbances molecular connectivity scales aim study explore changes functional connectivity typical sad methods investigated unmedicated untreated sad patients healthy controls using resting state functional magnetic resonance imaging fmri utilizing graph theory data driven hypothesis free approach model functional networks brain results comparing whole brain network properties using graph theory observed globally affected network topologies increasing pathlength sad nodal changes however highly restricted bilateral inferior occipital cortex interestingly found lateralization hyper connectedness restricted right inferior occipital cortex hyper efficiency found left inferior occipital cortex furthermore found nodes became hub like patients suggesting greater functional role conclusions work stresses importance abnormal intrinsic processing rest primarily affecting visual areas subsequently changing whole brain networks thus providing important hint towards potential future therapeutic approaches
although much known hydraulics xylem hydraulic interconnectivity dimensional scaling phloem respect xylem leaves adequately studied test alternative hydraulic architectural rules vinci rule murray rule physiological models munch pressure flow hypothesis using confocal electron microscopy well mathematical analyses examined hydraulic architecture mature leaves model species populus tremula alba across seven hierarchical orders vascular branching show phloem xylem conductive areas increase minor major veins sum conductive areas vein order increases exponentially major minor veins volume individual sieve tube vessel members increases minor major veins phloem conductive area scales isometrically respect xylem area across vein orders application first principles data shows conductive areas scale according vinci rule according murray rule phloem network poplar leaves generate pressure gradient envisioned munch hypothesis
hausdorff voronoi diagram family clusters points plane distance point cluster measured maximum distance point diagram defined nearest neighbor sense input clusters paper consider non crossing clusters plane combinatorial complexity hausdorff voronoi diagram linear total number points convex hulls clusters present randomized incremental construction based point location computes diagram expected time expected space techniques efficiently handle non standard characteristics generalized voronoi diagrams sites non constant complexity sites enclosed voronoi regions empty voronoi regions diagram finds direct applications vlsi computer aided design
increased angiogenesis bcr abl negative myeloproliferative neoplasms mpns recognized connection clinical molecular markers needs defined aims study assess bone marrow angiogenesis measured microvessel density mvd using antibodies analyze correlation mvd plasma angiogenic factors including vascular endothelial growth factor basic fibroblast growth factor interleukin examine association mvd clinicopathological molecular markers examined novo mpn patients polycythemia vera primary myelofibrosis pmf essential thrombocythemia age matched controls mvd analyzed immunohistochemistry hot spot method angiogenic factors immunoassay jakvf calr mutations dna sequencing allelic pcr mvd significantly increased mpns compared controls pmf correlation mvd plasma angiogenic factors found mpns mvd significantly increased patients jakvf mutation correlated jak mutant allele burden mvd rho mvd rho calr mutation mvd correlated leukocyte count serum lactate dehydrogenase hepatomegaly splenomegaly fibrosis significantly associated mvd mvd interleukin jak mutant allele burden jak homozygote status positive predictive value fibrosis patients prefibrotic pmf significantly higher mvd patients could recommend mvd additional histopathological marker distinguish two entities study also highlights strong correlation mvd plasma angiogenic factors jak mutant allele burden fibrosis mpns
remote laboratories allow students trainees fully access experiments providing necessary guidance constraining operation avoid dangerous situations paper remote laboratory monitoring controlling typical mechanical refrigeration system presented client server communication used connect local remote laboratory hoc labview based user interface allows monitor control plant laboratory used experimental aid teaching controller design refrigeration systems examples ranging open loop closed loop tests typical vapour compression cycle refrigeration system reported ifac international federation automatic control hosting elsevier ltd rights reserved
personal account life philadelphia association late ideas basaglia cooper deleuze esterson fanon foucault guattari laing szasz put practice cooper psychiatry anti psychiatry inspiration appeared international movement within psychiatry influenced among things foucault madness civilization szasz believed mental illness myth created society cooper believed family instrument oppression perpetrating psychological violence members laing believed one studied specific forms communication within families schizophrenics one could make madness intelligible therefore amenable form psychotherapy paper highlights evolving understanding psychosis within philadelphia association relationship psychosis psychoanalysis suggests far misguided blip history psychiatry anti psychiatry could seen revolutionized discourse relation psychosis way left worthy lasting legacy linking treatment treat one another
diagnostics cornerstone practice infectious diseases however various limitations frequently lead unmet clinical needs domains diagnostics focus narrowly defined questions provide readily interpretable answers use true gold standards development contrast infectious diseases diagnostics must contend scores potential pathogens dozens clinical syndromes emerging pathogens rapid evolution existing pathogens associated resistance mechanisms absence gold standards many situations spite challenges importance value diagnostics underestimated therefore antibacterial resistance leadership group identified diagnostics major areas emphasis herein provide overview development highlighting several examples innovation study design content execution advancing field infectious diseases diagnostics
cerebral amyloid angiopathy caa induces various forms cerebral infarcts hemorrhages vascular amyloid beta accumulation resulting acceleration cognitive impairment currently untreatable soluble amyloid beta protein likely impairs cerebrovascular integrity well cognitive function early stage alzheimer disease taxifolin flavonol strong anti oxidative anti glycation activities reported disassemble amyloid beta vitro vivo relevance remains unknown investigated whether taxifolin therapeutic potential attenuating caa hypothesizing inhibiting amyloid beta assembly may facilitate clearance several elimination pathways vehicle taxifolin treated swdi mice commonly used model caa used investigation cognitive cerebrovascular function well solubility oligomerization brain amyloid beta proteins investigated spatial reference memory assessed water maze test cerebral blood flow measured laser speckle flowmetry cerebrovascular reactivity evaluated monitoring cerebral blood flow changes response hypercapnia significantly reduced cerebrovascular pan amyloid beta amyloid beta accumulation found taxifolin treated swdi mice compared vehicle treated counterparts spatial reference memory severely impaired vehicle treated swdi mice normalized taxifolin treatment scoring similar wild type mice furthermore taxifolin completely restored decreased cerebral blood flow cerebrovascular reactivity swdi mice vitro thioflavin assay showed taxifolin treatment resulted efficient inhibition amyloid beta assembly addition filter trap assay elisa showed swdi mouse brain homogenates exhibited significantly reduced levels amyloid beta oligomers vivo taxifolin treatment suggesting effects taxifolin caa attributable inhibition amyloid beta oligomer formation conclusion taxifolin prevents amyloid beta oligomer assembly fully sustains cognitive cerebrovascular function caa model mice taxifolin thus appears promising therapeutic approach caa
studies south african liberation struggle focused political strategic concerns level formal organisations leadership yet anti apartheid struggle also impacted personal relationships social life put lives service article draws correspondence members african national congress exile based tanzania organisation chief representative region concerning permission recognition guidance love marriage family related matters period late early analyses demands struggle difficult exile context shaped love family relationships conceptions ways individual cadres negotiated personal lives engaging political struggle part collective movement disciplinary parental role anc exile exercised bureaucratic process developed manage relations also examined prism correspondence article argues governance personal life anc exile integral part nation building state making fulfilling bureaucratic affective functions
new technique called geotextile mattress floating curtain gmfc may advisable alternative countermeasure seabed erosion since allow deposited sediment dunes form naturally upstream downstream sides gmfc installed erosive flow however cyclic loading wave actions lead liquefaction seabed mattress reducing maximum friction resistance mattress even leading instability gmfc structure thus study series physical model tests rectangular flume carried investigate behavior single gmfc hydrodynamic environment around gmfc subjected wave loading wave force seabed recorded pressure gauges installed flume bed experimental results indicated area unmovable bed around gmfc suffered much higher hydrodynamic pressure wave action areas directly facing bottom openings gmfc prone bear higher cyclic force wave actions moreover results also illustrated highest cyclic force wave actions seabed appears distance mattress curtain height gmfc centerline parametric study indicated opening ratio significant impact wave force properties
multidrug resistance mdr major clinical obstacle successful treatment patients metastatic nasopharyngeal carcinoma npc results previous studies suggest micrornas mirna may involved promoting mdr multiple cancer types however role mir modulating mdr npc elusive present study mir expression cisplatin ddp resistant cne cells cne ddp compared parental counterparts using reverse transcription quantitative polymerase chain reaction fold reduction mir expression levels observed cne ddp cells compared parental cne cells ectopic expression mir transfecting cne ddp cells mir mimics increased ddp induced cytotoxicity apoptosis chemosensitivity contrast suppression mir transfecting cne cells mir inhibitors reduced ddp induced cytotoxicity apoptosis facilitated cisplatin resistance results suggest mir may regulate sensitivity npc cells ddp modulating expression levels antiapoptotic factor cell cll lymphoma collectively results present study highlight mir potential therapeutic target reversing mdr npc
paper presents new methodology designing non linear dynamic neural model state space representation furthermore application unscented kalman filter training designed neural model also shown final part work provides illustrative example application proposed methodology identification robust fault detection tunnel furnace
report two step synthesis core shell nanohybrid material visible near infrared nir photocatalysis core constituted nagdf upconverting nanoparticles ucnps bismuth ferrite bfo shell assembled around ucnps via hydrothermal process photocatalytic degradation assays methylene orange chlorophenol reveal core shell nanostructures possess remarkably enhanced reaction activity visible nir irradiation compared bfo powder alone bfo ucnp mixture photo charge scavenger tests fluorescent assays indicate hydroxyl radicals play pivotal role photodegradation mechanism enhanced photoactivity core shell structure attributed nir radiation converted visible light ucnps captured bfo via nonradiative luminescence resonance energy transfer process therefore core shell architecture optimizes solar energy use efficiently harvesting visible nir photons
current internet facing unprecedented demands challenges protocols designed incorporated system patchwork solving many issues patchwork approach non integrated security mechanisms appropriately address problems problem lies architecture protocols flexible network architecture explored new approach address issues technical non technical challenges present internet many flexible network architectures designed address infrastructural problems current internet service oriented network architecture one based service oriented architecture supporting short term long term demands evolve offers various flexible services without considering threats raised due lack security architecture paper discusses security requirements proposed architecture order avoid tolerate attacks network security communication networks copyright john wiley sons ltd
seasonal affective disorder underdiagnosed primary care setting mood disorder subtype characterized episodic major depression typically develops winter daylight hours short patients sad experience increased morbidity decreased quality life article focuses recognition management condition light therapy preferred treatment sad safe easy administer light therapy may combined pharmacologic therapy cognitive behavioral therapy cbt also positive therapeutic effect combined light therapy may help prevent sad subsequent seasons
purpose review purposes study examine relationships obesity wide range mental health issues identify sex differences exist may vary across disorders recent findings research sex differences relationship obesity psychiatric disorders abundant areas depression eating disorders others anxiety trauma substance use however disorders relationships obesity sex complex usually moderated additional variables thus studies find stronger relationships women depression obesity cross sectionally tell whole story longitudinal studies suggest relationship may also present among men particularly confounders considered eating disorders men women obesity fairly equally affected weight shape concerns may play role maintaining behaviors sexes weight stigma though seems worse consequences women men obesity summary sex differences exist relation associations mental health obesity however differences vary disorder disorder specific moderators playing role age depressive disorders comorbid depression anxiety disorders weight shape concerns eating disorders work needed understand sex differences play role relationship obesity anxiety trauma substance use disorders
investigate elastic buckling behavior self anchored suspension bridges subjected proportionally increasing dead loads new stability procedure proposed based deflection theory purpose finite element buckling analysis performed using initial state solution based unstrained length method ulm ref finite element solutions compared deflection theory shown main girder tower self anchored suspension bridge compression fundamental buckling modes tower dominant importantly observed local buckling within main girder supported hangers occurs without geometric change main cable higher buckling modes self anchored suspension bridge
background bipolar disorder may characterized presence psychotic symptoms comorbid substance abuse context structural metabolic dysfunctions reported psychosis addiction separately study aimed identifying neural substrates differentiating psychotic without substance abuse versus substance induced psychosis sip coupling first time magnetic resonance imaging mri positron emission tomography pet methods twenty seven type psychotic patients without substance abuse sip patients healthy controls enrolled study mri fdg pet scanning acquired results gray matter volume cerebral metabolism reductions temporal cortices observed patients compared healthy controls moreover distinct pattern fronto limbic alterations found patients substance abuse specifically patients substance abuse showed volume reductions ventrolateral prefrontal cortex anterior cingulate insula thalamus whereas sip patients dorsolateral prefrontal cortex posterior cingulate common alterations cerebellum parahippocampus posterior cingulate found substance abuse sip finally unique pattern volumes reduction concomitant increased striatal metabolism observed sip patients conclusions findings contribute shed light identification common distinct neural markers associated bipolar psychosis substance abuse future longitudinal studies explore effect single substances abuse patients first episode substanceinduced psychosis elsevier masson sas rights reserved
objectives study examined whether individuals parkinson disease increased vulnerability vascular related cognitive impairment relative controls underlying assumption behind hypothesis relates brain reserve vascular risk factors impair similar fronto executive cognitive systems methods sample included patients older controls total participants completed neuropsychological measures executive functioning processing speed verbal delayed recall memory language auditory attention cardiovascular risk assessed framingham cardiovascular risk index participants underwent brain imaging flair trained raters measured total regional leukoaraiosis periventricular deep subcortical infracortical results hierarchical regressions revealed severe cardiovascular risk related worse executive functioning processing speed delayed verbal recall parkinson patients controls severe cardiovascular risk related worse language functioning group controls contrast leukoaraiosis related cardiovascular risk executive functioning controls group conclusions overall results revealed cardiovascular risk factors independent risk factors cognitive impairment generally influence cardiovascular risk factors cognition similar patients controls
model timing game tax competition initial capital unevenly endowed within country tax policies determined majority voting regime model characterized novel feature decisive voter imports capital individual level country exports national level paper finds governments endogenously choose play sequential move game unlikely associate full capital ownership tax competition literature
aims objectives explore emergency nurses perceptions feasibility utility pain assessment advanced dementia tool people cognitive impairment pain assessment advanced dementia tool compared abbey pain scale doloplus pacslac objective determine observational pain assessment tool appropriate emergency department context cognitively impaired older person background number older people cognitive impairment conditions dementia presenting emergency department increasing approximately people years present cognitive impairment older people cognitive impairment often receive suboptimal pain management limited evidence use appropriateness dementia specific pain observation assessment tools design multicentre exploratory qualitative study conducted within constructivist paradigm methods focus group interviews conducted nurses across three hospital emergency departments data subject thematic analysis results six focus groups conducted nurses week period four themes emerged analysis cognitive impairment barrier pain management painad gives structure pain assessment painad assists convey pain intensity selection appropriate observational pain assessment tool conclusions study identified emergency nurses find challenging detect assess manage pain cognitively impaired people use painad helped address challenges compared tools nurses also identified important role family carers play pain assessment management older people cognitive impairment relevance clinical practice study generated new knowledge broad application across clinical settings assist transform pain management practice reduce human suffering use observational pain assessment tool provide greater practice consistency patients communication difficulties pain management older people cognitive impairment best achieved use appropriate observational pain assessment tool multidisciplinary approach includes person family carer
software cybernetics research apply variety techniques cybernetics research software engineering research fifteen years since dramatic increase work relating software cybernetics cybernetics viewpoint work mainly first order level namely software observation control beyond first order cybernetics software developers users running environments influence thus create feedback form complicated systems classify software cybernetics software cybernetics based first order cybernetics software cybernetics based higher order cybernetics paper provides review literature software cybernetics particularly focusing transition software cybernetics software cybernetics results survey indicate new research areas internet things big data cloud computing cyber physical systems even creative computing related software cybernetics paper identifies relationships techniques software cybernetics applied new research areas applied formulates research problems challenges software cybernetics application principles phase software cybernetics identifies highlights new research trends software cybernetic research elsevier inc rights reserved
labview one various programming platforms widely utilized researchers fraternities form industry academia due simple use graphical programming environment extra ordinary easy interface hardware labview equipped various built toolkits perform different measurement control tasks one tasks solving optimization problem often encountered researchers variety fields viz control engineering civil design machine design digital signal processing economics etc however standard labview package equipped single global optimization algorithm differential evolution algorithm exists need efficient global optimization techniques paper deals concern effort made develop widely established practiced global meta heuristic algorithm cuckoo search algorithm csa labview environment test csa implementation labview environment nine benchmark test functions used comparative study made algorithm found conducted studies csa efficient solving optimization problems better convergence rate repeatability
research proposed modified fruit fly optimization algorithm mfoa integrated adaptive array antenna aaa ghz wlan system principal components array antenna system encompass four array elements four band pass filters bpf four digital phase shifters four way power combiner splitter directional coupler radio frequency detector microcontroller unit mcu realization adaptive antenna system modified inverted antenna finite ground plane first innovated subsequently deployed element fourelement array antenna study simulations experiments carried four element aaas two configurations linear planar array configurations simulation experimental results revealed mfoa algorithmic scheme could determine direction maximum arrival signal efficient accurate manner also capable manipulating radiation pattern desired direction addition mfoa integrated four element aaa compact size operable ghz frequency band omnidirectional radiation pattern gain dbi wiley periodicals inc
diagnosis essential thrombocythemia polycythemia vera often made thrombotic event serious philadelphia negative chronic myeloproliferative neoplasia patients increased thrombotic risk assessed using various scoring systems far ideal individual risk currend trend personalised medicine requires finding useful thrombotic risk biomarker patients routine tests coagulation take account pro anti coagulant factors tests useful patients philadelphia negative myeloproliferative neoplasms thrombin generation reflects accurately balance pro anti coagulant factors parameters thrombin generation endogenous thrombin potential higher philadelphia negative myeloproliferative neoplasm patients especially jak carriers healthy controls even higher reactive thrombocytosis jak allele burden correlates higher thrombin generation potential patients treated hydroxycarbamidum instead jak positive patients philadelphia negative myeloproliferative neoplasms sensitive hydroxycarbamidum reflected lower values platelet thrombin generation potential use thrombin generation examination patients would enable detection imminent thrombosis personalised prophylactic management
recent advancement field distributed computing depicts need developing highly associative less expensive cache memories state art processors intel core etc hence various conventional studies introduced cache replacement policies one prominent key factors determine effectiveness cache memory conventional cache replacement algorithms found efficient memory management complexity analysis therefore significant thorough analysis required suggest new optimal solution optimizing state art cache replacement issues proposed study aims conceptualize theoretical model optimal cache heap object replacement proposed model incorporates tree based mru recently used pseudo lru least recently used mechanism configures jvm garbage collector replace old referenced objects heap cache lines performance analysis proposed system illustrates outperforms conventional state art replacement policies much lower cost complexity also depicts percentage hits cache heap relatively higher conventional technologies
background number retirements withdrawals lucky losers replacement player withdraws start tournament losing player qualifying round professional tennis tournaments increased reasons behind departures yet analyzed official consensus statement conducted allow general categorization injuries tennis purpose determine reasons departure injury rates professional tennis study design descriptive epidemiology study methods reasons departures collected official association tennis professionals atp women tennis association wta web pages tournaments apart major competitions australian open french open wimbledon open included period men women personal data tournament information surface match setting date reason obtained departure scenario results variations departure injury rates seen throughout season women left injured significantly men women mainly left thigh injuries whereas men left mainly back injuries playing surface influence risk lower back injuries women departures affected tournament round conclusion high number departures tournaments occurred past years atp wta circuits injuries main reasons departures regardless type departure player sex back thigh main locations injuries men women respectively
radiation induced fibrosis head neck well established pathophysiological process radiotherapy recently pentoxifylline tocopherol proposed treatments combat late complications radiation induced fibrosis way dealing osteoradionecrosis long history management radiation induced fibrosis anatomical sites paper review use sites head neck illustrate potential benefit offer patients british association oral maxillofacial surgeons published elsevier ltd rights reserved
isolation paradigm often used studying effects distinctiveness memory within paradigm isolated item appear early late list prior studies using isolation paradigm older adults placed isolated items late study list however smith used early isolation list found older adults showed early isolation effect dimension isolation readily detected numbers letters show isolation effect dimension difference subtle category membership current experiments replicate findings demonstrate judgments learning elevated isolated item former case latter case young older adults
objectives several attempts reduce incidence sport injuries using psychosocial interventions produced fruitful although inconclusive results paper presents effectiveness implementation issues pilot month stress management muscle relaxation program aimed reducing sport injury incidence design pre post treatment non treatment group comparison program administration program administered trained psychologist week session basis participants seventy four male soccer players four national youth league teams voluntarily participated teams randomly assigned either treatment non treatment group measures injury protocol self monitoring cards athletes satisfaction commitment survey coaches interview results group main effect time group interaction effect statistically significant eta average number injuries larger post treatment phase non treatment group eta significant decrease average number injuries intervention group implementing program eta conclusions controlled implementation psychosocial program effective reducing youth soccer sport injuries high level satisfaction commitment athletes well high acceptance coaches elsevier ltd rights reserved
objective characterize multiple dimensions benefits mediterranean diet sustainable diet order revitalize intangible food heritage country level develop multidimensional framework med diet four sustainability benefits mediterranean diet presented parallel major health nutrition benefits low environmental impacts richness biodiversity high sociocultural food values positive local economic returns design narrative review applied country level highlight multiple sustainable benefits mediterranean diet single multidimensional framework med diet setting subjects included studies published english peer reviewed journals contained data characterization sustainable diets mediterranean diet methodological framework approach finalized series meetings workshops conferences framework presented discussed ultimately refined results med diet provides conceptual multidimensional framework characterize mediterranean diet sustainable diet model applying principles sustainability mediterranean diet conclusions providing broader understanding many sustainable benefits mediterranean diet med diet contribute revitalization mediterranean diet improving current perception healthy diet also sustainable lifestyle model country specific culturally appropriate variations also takes account identity diversity food cultures systems expressed within notion mediterranean diet across mediterranean region parts world multidisciplinary studies needed assessment sustainability mediterranean diet include new dimensions
mechanical response wire strand inherently complex helical wires undergo evolving stress contact conditions strand loaded complications added strand behavior one wires break due strand degradation time although detailed investigation strand behavior critically important predicting capacity broken strand well developing new monitoring approaches wire break detection little study available literature wire breakage stressed strand paper provides extensive investigation stressing post breakage dynamic behavior prestressing strand finite element model generally useful study global strand response along many localized phenomena strong influence performance difficult capture either experimentally closed form analytical models investigations certain behaviors wire breaks however require relatively large even full scale model adequately develop contact frictional conditions moreover sizeable model account deviation points may avoid edge effects consequently several finite element parameters load ramp profile duration effects damping interwire friction become critical accurate efficient model paper first presents use parametrized model study strand behavior evaluates effects modeling parameters strand response load distribution redistribution among wires onset interwire motion also considered model used simulate wire breakage prestressing strand various aspects post breakage response examined numerical results show linear load ramp stressing quickly may lead inaccurate axial tension developed strand whereas inclusion nominal mass based damping found effective achieving quasi static solution reasonable computational cost addition wire break simulation results indicate breakage outer wire results greater prestress loss breakage center wire might important implications non destructive wire breakage detection elsevier ltd rights reserved
probabilistic inference large data sets challenging data management problem since exact inference generally hard often solved approximately sampling based methods today paper proposes alternative approach approximate evaluation conjunctive queries standard relational databases approach every query evaluated entirely database engine evaluating fixed number query plans providing upper bound true probability taking minimum provide algorithm takes account important schema information enumerate minimal necessary plans among possible plans importantly algorithm strict generalization known ptime self join free conjunctive queries query ptime algorithm returns one single plan furthermore approach generalization family efficient ranking methods graphs hypergraphs also adapt three relational query optimization techniques evaluate necessary plans fast give detailed experimental evaluation approach process provide new way thinking value probabilistic methods non probabilistic methods ranking query answers also note techniques developed paper apply immediately lifted inference statistical relational models since lifted inference corresponds ptime plans probabilistic databases
inositol trisphosphate receptors intracellular signaling critically involved regulating different steps autophagy lysosomal degradation pathway ryanodine receptors ryr intracellular release channels mainly expressed excitable cell types including muscle neurons however yet extensively studied relation autophagy yet aberrant expression excessive activity ryrs tissues implicated onset several diseases including alzheimer disease impaired autophagy regulation contributes pathology study determined whether pharmacological ryr inhibition could modulate autophagic flux ectopic ryr expressing models like hek cells cell types endogenously express ryrs like myoblasts primary hippocampal neurons importantly ryr overexpression hek cells impaired autophagic flux conversely cell models tested pharmacological inhibition endogenous ectopically expressed ryrs using dantrolene ryanodine augmented autophagic flux increasing lysosomal turn number autophagosomes autolysosomes measured mcherry punctaeicell increased control hek ryr cells dantrolene ryanodine treatments respectively moreover differentiated cells transmission electron microscopy demonstrated dantrolene treatment decreased number early autophagic vacuoles per cellular cross section modulation autophagic flux could linked functional inhibition ryr channels ryr inhibitors efficiently diminished number cells showing spontaneous ryr activity hek cell model control cells dantrolene ryanodine treatments respectively conclusion basal ryr mediated release events suppress autophagic flux level lysosomes elsevier inc rights reserved
research paper mainly deals comprehensive techno economic modeling multi objective optimization cchp system residential application internal combustion engine ice proposed prime power combined organic rankine cycle orc ejector refrigeration cycle erc domestic water heater dwh considered recover wasted heat ice exhaust gas water jacket common working fluids namely selected study comprehensive multi objective optimization applied determine optimal design parameters system two major objective functions exergy efficiency maximized total cost rate system minimized considered satisfying several reasonable constraints total cost rate objective function consists purchase equipment costs fuel cost environmental impact cost diesel engine capacity diesel engine part load expander inlet pressure expander extraction pressure extraction ratio condenser pressure evaporator pressure selected decision variables developed multi objective genetic algorithm used optimization tool ability better optimal results less computer running time observed working fluid good candidate exergy efficiency total cost rate point view examine effect decision variable objective functions sensitivity analysis performed finally ability system studied meet cooling heating electricity demand detached house defined load tehran elsevier ltd rights reserved
background poor retention care non adherence antiretroviral therapy art continue undermine success hiv treatment care programmes across world growing recognition multifaceted interventions application two adherence enhancing strategies may useful improve art adherence retention care among people living hiv aids empirical evidence shows multifaceted interventions produce better results interventions based singular perspective nevertheless bundle mechanisms multifaceted interventions promote art adherence poorly understood paper reviewed theories art adherence identify candidate potential mechanisms adherence club intervention works methods searched five electronic databases pubmed ebscohost cinahl psycarticles google scholar using medical subject headings mesh terms manual search citations reference list studies identified electronic databases also done twenty six articles adopted theory guided inquiry antiretroviral adherence behaviour included review eleven cognitive behavioural theories underpinning studies explored examined theory possible generative causality using realist evaluation heuristic context mechanism outcome configuration selected candidate mechanisms thematically results identified three major sets theories information motivation behaviour social action theory health behaviour model explain art adherence although show potential explaining adherence bebahiours fall short explaining exactly various elements outline combine explain positive negative outcomes candidate mechanisms indentified motivation self efficacy perceived social support empowerment perceived threat perceived benefits perceived barriers although candidate mechanisms distilled theories employed explore adherence art various studies theories provide explanatory model adherence based realist logic conclusions identified theories candidate mechanisms offer possible generative mechanisms explain patients adhere antiretroviral therapy study provides crucial insights understanding multifaceted adherence enhancing interventions work findings implications eliciting programme theories group based adherence interventions adherence club intervention
objective investigate association subclinical hypothyroidism preterm contractions methods prospective observational study among women weeks gestation known thyroid function abnormality preterm uterine contractions ptc patients underwent laboratory evaluation thyroid stimulating hormone tsh free thyroxin patients without ptc compared results association found ptc subclinical hypothyroidism rate spontaneous preterm delivery ptd comparable women abnormal normal thyroid function tests excluding indicated ptd patients study group higher rate spontaneous ptd versus patients past ptd preterm contractions higher rates hypothyroxinemia compared patients without past ptd versus patients past ptd regardless presence absence ptc higher rate subclinical hypothyroidism compared patients ptc without ptd versus conclusions association found ptc subclinical hypothyroidism entire cohort except patients preterm contractions history past ptd specific group patients might benefit thyroid function evaluation
aim present study determine whether patients borderline personality disorder bpd show neurological soft signs compared healthy controls furthermore sought examine role common symptoms related bpd depression anxiety impulsivity association neurological soft signs thirty patients borderline personality disorder thirty hospital based controls examined neurological soft signs total score neurological soft signs bpd significantly higher controls terms subscales patients higher scores sensory integration motor coordination neurological soft signs compared control group multiple regression analysis showed impulsivity score best significant predictor neurological soft signs bpd increase neurological soft signs patients bpd may address non focal neurological dysfunction borderline personality disorder elsevier ireland ltd rights reserved
objectives examine association site gynecology availability sex specific services policies department veterans affairs emergency departments eds research design cross sectional analysis using data national inventory emergency services women gynecologist staffing information office productivity efficiency staffing subjects directors medical centers measures used logistic regression evaluate association site gynecologist full time equivalents ftes availability sex specific services consult follow within gynecologist emergency contraception rho immunoglobulin pelvic ultrasound transfer policies obstetric gynecologic emergencies analyses adjusted number encounters women results greater gynecologist fte associated increased odds site availability gynecology consultation odds ratio confidence interval gynecologist follow within encounter positive trend seen availability rho immunoglobulin presence transfer policies obstetric gynecologic emergencies half facilities fte transfer policies place development conclusions site gynecologist fte associated improved availability sex specific care eds development transfer processes obstetric gynecologic emergencies settings limited site gynecology needed
every performance officially sanctioned meet registered usa swimmer recorded online database times dating back first time statistical analysis machine learning methods systematically applied swim records study investigate performance features strokes function age gender variances performance males females different ages strokes studied correlations performances different ages estimated using pearson correlation regression analysis show performance trends males females different ages suggest critical ages peak training moreover assess twelve popular machine learning methods predict classify swimmer performance method exhibited different strengths weaknesses different cases indicating one method could predict well strokes address problem propose new method combining multiple inference methods derive wisdom crowd classifier wocc simulation experiments demonstrate wocc consistent method better overall prediction accuracy study reveals several new age dependent trends swimming provides accurate method classifying predicting swimming times
controversies surgical protocols efficacies total hip arthroplasty tha ankylosing spondylitis still exist aim study retrospectively analyze perioperative managements outcomes related performing tha patients data patients underwent thas retrospectively analyzed clinical imaging data collected preoperatively postoperatively follow period surgical efficacy using posterolateral approach cementless prostheses selected cases mean follow period years range years inclinations anteversions acetabular cups degrees degrees range degrees degrees degrees degrees range degrees degrees respectively mean visual analog scale vas score decreased range preoperatively range final follow mean harris hip score hhs improved range range postoperative range motion rom flexion improved degrees degrees range degrees degrees preoperatively degrees degrees range degrees degrees final follow rom extension improved degrees degrees range degrees degrees degrees degrees range degrees degrees heterotopic ossification documented hips signs stable fibrous ingrowth bone ingrowth detected hips respectively sciatic never injury occurred cases treated conservatively signs periprosthetic fractures dislocation prosthesis loosening surgical efficacies tha patients severe hip involvement satisfactory
non alcoholic fatty liver disease nafld common patients type diabetes approximately two thirds diagnosis disease currently validated treatment nafld weight loss number studies animal models human trials evaluated effects glucagon like peptide receptor agonists glp ras liver fat content suggest treatment could represent new alternative nafld management review focus main studies regarding effects glp ras nafld also mechanisms might explain beneficial effects liver diseases analyzed elsevier masson sas rights reserved
recent decades fractional order systems found useful many areas physics engineering hence efficient accurate analog digital simulations numerical calculations become important especially fields fractional control fractional signal processing fractional system identification article new analog digital simulations numerical calculations perspectives fractional systems considered main feature work introduction adjustable fractional order structure fractional integrator facilitate improve simulations fractional order systems well numerical resolution linear fractional order differential equations first basic ideas proposed adjustable fractional order structure fractional integrator presented analog digital simulations techniques fractional order systems numerical resolution linear fractional order differential equation exposed illustrative examples step work presented show effectiveness efficiency proposed fractional order systems analog digital simulations implementations techniques
serotonin type receptors ligand gated ion channels formed five subunits hta encoded htra htrb htrc htrd htre genes functional receptors pentameric complexes diverse composition different receptor subtypes confer predisposition nausea vomiting chemotherapy pregnancy following surgery addition different subtypes contribute neurogastroenterologic disorders irritable bowel syndrome ibs eating disorders well comorbid psychiatric conditions receptor antagonists established treatments emesis ibs beneficial treatment psychiatric diseases several case control pharmacogenetic studies demonstrated association htr variants psychiatric neurogastroenterologic phenotypes recently potential predictors nausea vomiting treatment psychiatric disorders became evident information available serotonin receptor htr gene allelic variant database contains five sub databases one five different serotonin receptor genes htra information htr variants functional relevance associated phenotypes pharmacogenetic data drug response side effects available central information pool help clinicians well scientists evaluate findings use relevant information subsequent genotype phenotype correlation studies pharmacogenetic approaches
paper considerations related possibly best selection current mirror architecture current biasing operational amplifier pixel matrices presented monte carlo simulations focusing global parameter variation conducted presented discussed
paper analysis state art active elements analog signal processing presented support contrast conventional operational amplifiers voltage mode also current mixed mode operations several problems addressed associated utilization elements linear applications particularly frequency filters methodology proposed generates number fundamentally new active elements potential utilization various areas signal processing
background depression currently underdiagnosed among older adults part novel assessment nutrition aging nana validation study older adults self reported mood using touchscreen computer three one week periods demonstrate potential data predict future depression status methods analysed data nana validation study using machine learning approach applied least absolute shrinkage selection operator logistic model averages six measures mood depression status according geriatric depression scale weeks later outcome variable tested multiple values selection parameter order produce model low deviance used cross validation framework avoid overspecialisation receiver operating characteristic roc curve analysis determine quality fitted model results model report contained coefficients two variables sadness tiredness well constant cross validated area roc curve model limitations results based small sample methodology selection variables appears suitable problem hand suggesting promise wider study ultimate deployment older adults increased risk depression conclusions identified self reported scales sadness tiredness sensitive measures potential predict future depression status older adults partially addressing problem underdiagnosis
aim study idiopathic pulmonary fibrosis ipf progressive lung disease lethal chronic complications viral infections may associated ipf fibrotic lung diseases present study investigate first time iran related viral etiology ipf order detect three respiratory viruses human adenovirus enterovirus bocavirus materials methods cross sectional study supported iran university medical sciences tehran iran diagnostic criteria ipf based internationally accepted clinical imaging criteria accordance ipf guidelines nasopharyngeal swabs broncho alveolar lavage bal samples obtained lung ipf patients diagnosed sophisticated practitioner april february real time polymerase chain reaction pcr method performed detect three viruses fluorescence dye labeled probe recorded results order create positive negative controls spss version software used calculate basic descriptive frequency features results specimens male female total mean age standard deviation pcr assay results illustrated infection human adenovirus enterovirus bocavirus detected samples significant results ipf incidence variables significant conclusion causes ipf iranian patients need research although based results study association human adenovirus enterovirus bocavirus ipf elsevier ltd rights reserved
detecting cancer early stage useful better patient prognosis treatment planning even though several preliminary tests non invasive procedures conducted detection cancer various organs histopathology study inevitable considered golden standard diagnosis cancer today cost electronic components slashed computers high memory capacity better processing capabilities built furthermore imaging modalities also developed great extent interestingly computers help doctors interpret medical images diagnosis process thus area computer aided assisted diagnosis cad born consequently diagnosis procedures become reproducible reliable less subject observer variations survey explores state art materials methods used cad detect cancer histopathology images
little research field mathematics education directed towards emotions students beyond emotions problem solving particular daily emotions students mathematics class sparsely studied field mathematics education order fill gap qualitative research aims identify high school students emotional experiences mathematics classroom identify appraisal structures support emotional experiences focus group interviews carried theoretical saturation data achieved nine focus groups interviews data analysis based theory cognitive structure emotions specifies eliciting situations emotion variables affect intensity emotional experiences structure follows satisfaction disappointment hope fear joy distress boredom interest pride reproach self reproach like dislike results show emotional experiences students based appraisals events objects agents terms structure goals
individual placement support ips model supported employment people serious mental illness evidence based practice factors including national learning community promoting ips enforcement supreme court olmstead decision spurred growth ips nationwide study first evaluated national prevalence quality ips programs evaluated impact learning community membership olmstead settlements ips program penetration quality across united states interviewed representatives state behavioral health agencies state vocational rehabilitation agencies survey questions examined number ips programs state presence olmstead settlement mandating employment services people serious mental illness presence three indicators quality ips programs collaboration state behavioral health vocational rehabilitation agencies regular independent fidelity monitoring technical assistance training ips programs respondents states including states ips learning community outside learning community reported total ips programs nationwide state ips program penetration rate number ips programs per people ranged among states ips penetration rate similar learning community non learning community states ips learning community states much likely non learning community states ips report presence three quality indicators eleven states reported olmstead settlements positively impacted employment services people serious mental illness among states ips programs olmstead states differ non olmstead states ips program penetration quality indicators nationally states provide ips programs within state penetration rate quality implementation vary widely learning community non learning community states ips differ prevalence ips programs learning community states much likely report key quality indicators may enhance states potential sustaining expanding ips olmstead settlements yet shown direct impact penetration quality ips department justice continues enforce supreme court olmstead decision significance may increase
golden apple snail pomacea canaliculata invasive pest originating south america already found asia southern united states recently aiming target immune system snail way control spreading developed organ specific transcriptomes looked molecules controlling replication differentiation snail hemocytes prolcineticin domain containing protein astakine cytolcine known thus far capable regulating invertebrate hematopoiesis analyzed transcriptomes looking molecules containing prokineticin domain identified prokineticin like protein pip called pip analyzed real time pcr qpcr expression control snails highest levels plp detected digestive gland ampulla hemocyte reservoir pericardial fluid hematopoietic district tested plp expression triggering hematopoiesis via multiple hemolymph withdrawals bacterial challenge lps injection cases reduction pcplp mrna observed multiple hemolymph withdrawals caused significant decrease plp mrna pericardial fluid circulating hemocytes lps injection promoted plp mrna drop anterior kidney mantle gills organs may act immune barrier molluscs data indicate important role prokineticin domain containing proteins immunomodulators also gastropods dynamic expression may serve biosensor gauge effectiveness immunological interventions aimed curtailing spreading gastropod pest canaliculata elsevier ltd rights reserved
differentiation self dos key concept bowen theory indicating process begins early infancy progresses throughout childhood adolescence reach basic level early adulthood study examined psychometric properties italian version differentiation self inventory revised dsi skowron schmitt journal marital family therapy multidimensional measure assessing dos conceptualized bowen sample comprised subjects age year exploratory confirmatory factor analyses showed italian dsi possesses good psychometric properties internal consistencies adequate correlations dyadic adjustment scale symptom checklist revised trait form state trait anxiety inventory consistent theoretical relations among constructs findings confirm use dsi psychometrically sound measure differentiation self italian context implications future research clinical practice addressed
paper extends recently proposed robust computational framework constructing boundary representation brep volume swept given smooth solid moving along one parameter family rigid motions extension allows input solid sharp features thus significant useful generalization work naturally requires precise description geometry surface generated sweep sharp edge supported two intersecting smooth faces uncover geometry along related issues like parametrization singularities via novel mathematical analysis correct trimming surface achieved analysis interplay cone normals sharp point trajectory overall topology explained key lifting theorem allows compute adjacency relations amongst entities swept volume relating corresponding adjacencies input solid moreover global issues related body check orientation singularities self intersections efficiently resolved examples pilot implementation illustrate efficiency effectiveness framework
aim assess protective role breast feeding infants cmpa related aeds well utility marker disease evolution methods breast feeding children cmpa related aeds males females mean age months mild aeds moderate aeds severe aeds artificial feeding babies males females mean age months mild aeds moderate aeds severe aeds evaluated patients serum levels detected results significant score atopic dermatitis scorad index point differences breastfed breastfed children detected serum levels lower children cmpa related aeds compared healthy control group moreover significant inverse correlation serum levels scorad enrolled groups also noted particular levels groups significantly lower children severe symptoms conversely serum levels significantly increased children mild severe symptoms groups furthermore breastfed children lower severe symptoms higher serum levels finally serum total ige levels negatively correlated serum levels breastfed non breastfed children cmpa related aeds conclusions reported exclusive breast feeding induces hyposensitization children cmpa related aeds associated minor disease severity higher serum levels resulting useful disease monitor marker elsevier gmbh rights reserved
disturbing increase children autism spectrum disorder asd malaysia lot efforts studies put forward towards understanding managing matters related asd one way find means easing social communications among children caretakers particularly intervention caretaker able comprehend children emotional state mind prior therapy sort trust attachment developed however regulating emotions challenge children nonverbal communication facial expression difficult asd children therefore proposed use walking patterns gait detect type emotions asd children even though using gait emotion recognition common among normal individuals none found done children asd thus aim paper conduct preliminary review possibilities carrying gait based emotion detection among asd children regards emotional types gait parameters methods gait data acquisition authors published elsevier
development applications described ncl language noticed reusing document models structures enabling repetitions common codes applications thus due need generalize development applications described ncl language created luar templates processing system luar system templates processor developed lua language library keep aggregate collection templates sharing developers paper goal present evaluation luar system software engineering experimental techniques language ncl lua courses taught undergraduate students group compared development time two applications utilizing different languages result showed development luar language productive development purely ncl development time economy approximately depending kind application compared authored ncl
background astrocyte elevated gene aeg related tumorigenesis deterioration different cancers including non small cell lung cancer nsclc however effect aeg nsclc remains unclear study aimed investigate clinical significance effect aeg biological function nsclc results aeg significantly overexpressed nsclc tissues closely correlated deterioration nsclc based tissue microarray tcga database meta analysis knock aeg proliferation migration invasion nsclc cells inhibited tumorigenic angiogenic ability nsclc cells weakened furthermore aeg expressed genes significantly related ampk signaling pathway based bioinformatics approaches materials methods tissue microarray cancer genome atlas tcga database well meta analysis performed analyze relationship aeg clinicopathological parameters nsclc furthermore immunocytochemistry western blot analysis scratch assay colony formation assay transwell migration invasion assay chick embryo chorioallantoic membrane cam model conducted explore effect aeg nsclc vitro vivo additionally bioinformatics analyses carried assess potential pathways networks expressed genes aeg conclusions aeg positively activated tumorigenesis deterioration nsclc hypothesize aeg could play important role nsclc via ampk signaling pathway inhibiting expression aeg expected become novel method therapeutic strategies nsclc
try find old case matching problem description attribution solve new problem find important obstacle attribution ambiguity problem description especially attribute value changes time changes meaning attribute therefore causes terrible new problem solving old case solution study proposes new problem solution ambiguous terms types time problems current time sequence time non sequence time respectively finding case principle ontology tfsql programming cases front temporal fuzzy case addition set temporal fuzzy linguistic term explain ambiguous problem changed time including saving set commands managing fuzzy expression meta knowledge base saved case oracle relational database management system designed range case factors form conceptual meta scheme natural language information analysis method niam mapping cases relational scheme collecting details cases
paper presents techno economic analysis hybrid system powering school misurata libya potential renewable power system school evaluated homer optimization model used evaluate different possible configuration options supplying electrical load daily typical energy consumption profiles four seasons design based medium size school spring summer autumn weather conditions extreme winter decreases load demand seasons winter weather conditions used basis peak energy demand expected lighting heating loads dominate climate libya winter electrical load found maximum load homer software tool used determine optimum size specifications renewable power system solar radiation wind speed maximum values kwh fuel price assumed minimum feasible power system economically tur gen battery total net present cost npc cost energy coe kwh renewable fraction solar radiation wind speed fuel price assumed average values kwh optimal solution also tur gen battery npc coe kwh solar radiation wind speed presumed minimum values kwh fuel price assumed maximum feasible economical system still tur gen battery npc coe kwh excess electricity hybrid power system spring summer autumn sold utility general electrical network used applications enhance economical feasibility hybrid power systems schools authors published elsevier ltd
objective study aimed explore whether functional cypd polymorphisms associated susceptibility autoimmune diseases methods meta analysis conducted associations autoimmune diseases functional cypd polymorphisms cypd phenotypes results twelve studies patients controls included autoimmune disease cypd allele significantly associated overall group consistent hardy weinberg equilibrium stratification ethnicity indicated cypd allele autoimmune diseases associated caucasians cypd allele also associated autoimmune diseases caucasians stratified autoimmune disease type revealed cypd genotype associated systemic lupus erythematosus sle ankylosing spondylitis cypd phenotype significantly associated autoimmune diseases caucasians sle conclusions meta analysis indicates cypd polymorphisms cypd phenotype associated susceptibility autoimmune diseases caucasians particularly cypd polymorphism cypd phenotype risk factors sle development
background although foxe initially recognized role thyroid organogenesis recently strong association identified foxe locus thyroid cancer role foxe adult thyroid particular regarding cancer risk well established hypothesised discovering key foxe transcriptional partners would turn identify regulatory pathways relevant role oncogenesis results transcription factor binding array elk identified bind foxe confirmed physical association heterologously transfected cells mammalian two hybrid assays thyroid tissue endogenous foxe shown bind elk using chip assays factors bound thyroid relevant gene promoters tpo tert close proximity using combination electromobility shift assays tert promoter assays sirna silencing found foxe positively regulated tert expression manner dependent upon association elk treating heterologously transfected thyroid cells mek inhibitor inhibited foxe elk interaction reduced tert tpo promoter activity methodology investigated foxe interactions within vitro thyroid cell models human thyroid tissue using combination immunoprecipitation chromatin chip gene reporter assays conclusions foxe interacts elk thyroid relevant gene promoters establishing new regulatory pathway role adult thyroid function coregulation tert suggests mechanism allelic variants near foxe associated thyroid cancer risk
paper proposed novel model multiple fractured horizontal wells mfhw consideration pressure drop wellbore begin proposed analytical model incorporating turbulent flow wellbore darcy flow reservoir hydraulic fractures effect stress sensitivity permeability model solved used mathematical methods line source function pedrosa substitution newton raphson algorithm based solution pressure transient behavior mfhw obtained finally model validation sensitivity analysis conducted results validations show good matches among results analytical results numerical results according results sensitivity analysis find pressure depletion decreases fracture volume increases effect pressure depletion becomes weaker increasing pressure drops within wellbore pressure depletion increases increase reynolds number relative pipe roughness decreases increase reservoir wellbore constant effects reynolds number reservoir wellbore constant relative pipe roughness pressure behavior become stronger fracture parameters increase especially fracture number also found relative pipe roughness mainly affects flow regimes early time including bilinear flow formation linear flow reynolds number reservoir wellbore constant influence flow regimes work provides guidelines understanding effects wellbore hydraulics well performance tight gas reservoirs elsevier rights reserved
integrative medicine received increasing attention since studies explored key factors model health care study aimed describe model leading centers operating usa germany item structured survey semi structured interviews conducted six centers providing integrative medicine usa germany analyzed using convergent mixed method approach elements common across six centers following involvement general physicians delivering complementary alternative medicine cam services requirement medical referral recommendation cam services involvement integrative physician gatekeeper focus research education clinical practice ongoing academic activities key elements differentiating two countries following level requirements referral cam services differences service delivery including treatment modalities used accessibility cam services patients interaction team members patients perception cam perception patient centered care themes underpinning elements following cultural aspects conceptualizing health care communication within programs resource availability delivering services impacts patient engagement team collaboration framework delivering health care requires model care encourages interaction stakeholders developing comprehensive conceptual framework support practice required facilitate efficient safe patient care
introduction reading mind eyes test hereafter eyes test considered advanced task theory mind aimed assessing performance participant perspective takingthat ability sense understand people cognitive emotional states study item response theory analysis applied adult version eyes test methods italian version eyes test administered undergraduate students genders males modified parallel analysis mpa used test unidimensionality marginal maximum likelihood estimation used fit parameter logistic model data differential item functioning dif due gender explored five independent methods results mpa provided evidence favour unidimensionality rasch model superior two models explaining participants responses eyes test robust evidence gender related dif eyes test although differences may exist items reflection real differences group conclusions study results support one factor model eyes test performance eyes test defined participant ability perspective taking researchers cease using arbitrarily selected subscores assessing performance participants eyes test lack gender related dif favours use eyes test investigation gender differences concerning empathy social cognition
new advances computer hardware software users widespread accessibility multicore devices inside personal computers making feasible fast indoor airflow simulations exciting preliminary results cross platform parallel computing framework opencl using specific hardware reported however results largely based two hypotheses opencl code devices generate results device running parallel multiple processors faster running sequential single processor study attempted evaluate two hypotheses systematically studying accuracy computing speed opencl indoor airflow simulations fast fluid dynamics ffd code selected exemplar indoor airflow simulation program compare cross platform ability opencl evaluation performed using four graphics processing units gpus five central processing units cpus three manufacturers different degrees computing capability mounted two operating systems test subjects evaluated using four case studies consisting various indoor airflows sequential ffd code programmed computational fluid dynamics cfd program first used perform case studies generate numerical benchmarks comparison numerical simulation results experimental data showed cfd ffd predict studied flows averaged relative errors respectively afterwards accuracy speedup opencl code compared numerical benchmarks although opencl code cpus generated identical numerical results opencl results gpus slightly dissimilar likely due varying interpretations manufactures institute electrical electronics engineers standard depending hardware speedups opencl code varied times cpus times gpus slowdown computing speed happened running opencl two core cpu windows operating system using boot camp mac computer finally separate study relationship speedup global work size showed speedup achieved using amd firepro gpu
ideas reference common human beings frequent certain psychopathological disorders mainly concerning psychotic spectrum purpose study attempt construct model predicting appearance ideas reference test relationship personality based gray model emotional self consciousness variables five hundred seventy four participants patients several different psychopathological diagnoses filled referential thinking scale ref ghq self consciousness scale scs spsrq scale resulting model found full mediation sensitivity punishment sensitivity reward depression public self consciousness anxiety ideas reference regardless group patients nonpatients result based appearance anxiety symptomatology explains variance scores showing presence ideas reference therefore enables prediction set vulnerabilities established self reports could lead psychological state high general pathological risk proneness psychosis particular
introduction cognitive behavioral therapy cbt shown effective mitigating various psychosocial impacts breast cancer long term studies yielded mixed findings outcome cbt breast cancer settings especially respect quality life qol quantified degree stress qds evidence acquisition medline cochrane embase google scholar databases searched randomized controlled trials relevant use cbt variants breast cancer patients selected pooled results meta analyzed evidence synthesis six studies qualified inclusion meta analysis results six pooled studies demonstrate cbt improves qol standardized mean difference reduces qds standardized mean difference breast cancer survivors however interpretation results requires caution given small number eligible studies comprising total patients since literature also includes trials cbt combined various therapies including hypnosis exercise treatment stress management promising results breast cancer settings expanded clinical research likely demonstrate overall benefit cbt conclusions despite meta analysis fails support use cbt improve qol reduce stress breast cancer survivors cbt appears promising therapeutic intervention many psychosocial impacts breast cancer
safety climate long considered leading indicator management construction safety although previous research concluded safety climate organization significantly affected communication among individuals limited number construction studies explored relationship mediated organizational fit redress deficiency study investigated association communication safety climate mediated person organization fit first baseline communication responsibilities established analyzing project related documentation four subcontractors china review documentation responses collected subjected social network analysis sna develop metrics gauge communication performance analyzing person organization fit terms communication determined degree centrality pof betweenness centrality pof association communicative performance safety climate established analyses revealed high pof yield organizational environment restricts team communication thus limiting opportunities improve organization safety climate contrast high pof generate relaxing atmosphere managers promote open communication thus facilitating improvement organization safety climate given findings study provides new perspective investigating relationship communication safety climate construction industry provides basis future research area
olfactory dysfunction migraine associated long time study planned compare olfactory functions patients migraine osmophobia patients migraine osmophobia addition normal control group using sniffin sticks test main distinction study qualitative quantitative properties olfactory functions threshold discrimination identification evaluated separately jointly thirty healthy person aged women men migraine patients aged women man included study patients inquired osmophobia assessed hedonic tone assessment osmophobia tested perfume cigarette smoke leather stale food soy sauce fish spices coffee smells olfactory functions assessed sniffin sticks smell test thresholds discrimination identification determined patient migraine patients osmophobia threshold migraine patients without osmophobia threshold threshold control group discrimination score migraine patients osmophobia patients without osmophobia control group migraine patient without osmophobia threshold discrimination identification tdi scores lower control group important parameter study discrimination scores especially lower patients osmophobia believe decrease discrimination migraine patients osmophobia claim smell everything sensitive smells significant studies smell discrimination help better understand conditions especially anosmia hyposmia upper respiratory tract infections parosmia
set novel explicit expressions identification stable unstable integrating first order plus dead time process dynamics presented absence sensor noise static load disturbances autonomous relay control system asymmetrical relay induces smooth limit cycle process output dynamic model parameters estimated using set proposed expressions depend parameters limit cycle output derivatives however practice process output generally corrupted measurement noise thereby rendering erroneous identification process dynamics furthermore static load disturbance identification test also induces asymmetrical limit cycle output resulting inaccurate measurements hence fast fourier transform technique biased relay feedback methods implemented obviate problem asymmetries chattering limit cycle output yielding original limit cycle subsequent derivatives proposed method validated considering five typical examples literature extensive comparison study existing approaches based nyquist plots demonstrate efficacy method presented
current accurate stereo matching algorithms employ key techniques suitable parallel gpu architecture tricky cumbersome directly take techniques gpu applications trying tackle difficulty design two gpu based stereo matching algorithms one using local fixed aggregation window whose size configurable using adaptive aggregation window includes necessary pixels use winner takes wta principle optimization plain voting refinement post processing need complex data structures aim implement gpu platforms fast stereo matching algorithms produce results level quality wta local dense methods use window based cost aggregation gpu based implementation fixed window partially demosaiced cfa stereo matching application accelerations times obtained large size images gpu based implementation adaptive window color stereo matching application experiment results show handle four pairs standard images middlebury database within roughly elsevier rights reserved
background food allergies increasing prevalence treatment strategies currently available cure dogs food allergy past decade experimental food allergen specific sublingual immunotherapy slit emerged potential treatment food allergies human medicine however slit investigated dogs therefore objective study prospectively evaluate safety tolerability dispenser sterility slit healthy dogs testing food allergic dogs eight experimental healthy beagle dogs never orally exposed peanut randomized two groups receive slit peanut placebo months subjects monitored daily local systemic adverse effects blood samples complete blood count serum biochemistry urine urinalysis collected dogs body weight recorded day slit treatment sera determination peanut specific igg ige collected day intradermal tests performed day day experiment content dispenser used administer treatment placebo tested sterility usage order assess presence absence sensitization dogs challenged months end study peanut extract daily days results dogs completed study treatment provoke either local systemic side effects peanut specific igg significantly increased treatment group even though significant increase peanut specific ige also seen intradermal tests negative dogs experiment challenge test trigger adverse reactions treated dogs shows protocol cause sensitization peanut nevertheless primed immune system indicated humoral immune response dispenser solutions sterile conclusions results demonstrate used peanut slit protocol well tolerated safe healthy dogs studies evaluate tolerability safety efficacy dogs food allergy
objective assess year golimumab gol safety rheumatoid arthritis psoriatic arthritis psa ankylosing spondylitis methods subcutaneous gol every weeks evaluated phase trials patients active psa safety data year pooled across trials evaluating methotrexate mtx naive mtx experienced antitumor necrosis factor tnf experienced patients psa trial trial data summarized derived placebo controlled weeks uncontrolled study periods adverse events special interest serious infections opportunistic infections deaths malignancies demyelination tuberculosis incidence per patient years yrs determined results across trials patients received placebo received gol safety followup extended averages weeks placebo gol respectively respective placebo gol incidence yrs year lymphoma demyelination death lymphoma demyelination incidence appeared higher among patients receiving gol conclusion gol safety year remained consistent previously reported year findings tnf antagonists numerically higher incidences lymphoma demyelination observed versus clinicaltrials gov identifiers nct nct forward nct nct reveal nct raise
maternal feeding frequent intervention target prevention early childhood obesity longitudinal associations feeding child overweight poorly understood observational cohort study sought examine cross lagged associations maternal feeding overweight across ages months feeding measured maternal self report age child weight length measured cross lagged analysis used evaluate longitudinal associations feeding overweight adjusting infant birth weight maternal body mass index maternal education maternal depressive symptoms sample white male mothers high school education less total sample overweight age respectively pressuring finish restrictive regard amount restrictive regard diet quality laissez faire regard diet quality responsiveness satiety indulgent permissive indulgent coaxing indulgent soothing indulgent pampering tracked strongly across toddlerhood significant associations maternal feeding child overweight either cross sectional cross lagged associations results support strong causal role feeding childhood overweight future work longitudinal work consider alternative approaches conceptualizing feeding alternative measurement approaches elsevier ltd rights reserved
rett syndrome rtt requires total caregiver attention leads potential difficulties throughout life caregiver burden inventory designed alzheimer disease modified rtt caregiver inventory assessment rtt cia reliability face construct concurrent validity assessed caregivers individuals rtt chi square fisher exact test categorical variables tests wilcoxon two sample tests continuous variables utilized survey completed caregivers caregivers completed follow assessment exploratory factor analysis revealed good agreement physical burden emotional burden social burden internal reliability high cronbach alpha rtt cia represents reliable valid measure providing needed metric caregiver burden disorder
indoor localization key topic ambient intelligence aml research community scenarios recent advancements wearable technologies particularly smartwatches built sensors personal devices smartphones seen breakthrough making concrete envisioned smart environment paradigm particular scenarios devoted indoor localization represent key challenge addressed many works try solve indoor localization issue lack common dataset frameworks compare evaluate solutions represent big barrier overcome field unavailability uncertainty public datasets hinders possibility compare different indoor localization algorithms constitutes main motivation proposed dataset described herein collected geo magnetic field fingerprints together inertial sensor data two campaigns performed environment retrieving sincronized data smartwatch smartphone worn users purpose create present public available dataset goal work
alzheimer screening tests commonly used doctors diagnose patient condition stage early possible tests based pen paper interaction embrace advantages provided new technologies paper proposes novel alzheimer screening tests based virtual environments game principles using new immersive technologies combined advanced human computer interaction hci systems new tests focused immersion patient virtual room order mislead deceive patient mind addition propose two novel variations turing test proposed alan turing method detect dementia result four tests introduced demonstrating wide range screening mechanisms could designed using virtual environments game concepts proposed tests focused evaluation memory loss related common objects recent conversations events diagnosis problems expressing understanding language ability recognize abnormalities differentiate virtual worlds reality humans machines proposed screening tests evaluated tested using patients healthy adults comparative study state art alzheimer screening tests results show capacity new tests distinguish healthy people alzheimer patients elsevier inc rights reserved
work investigation design direct drive wave energy conversion system seaquest concept presented involves steps project marine environment analysis problems linked connection grid passing sizing procedure innovative arc shaped electrical generator flux switching principle applied analysis optimization performance verification fea study suitable control strategies particular attention given specificities new particular generator presents non constant rotational speed reciprocating motion border effects arch shaped generator compared traditional rotating machine directly coupled shaft moved pendulum published elsevier ltd selection peer review responsibility centre renewable energy
temporomandibular disorder tmd musculoskeletal condition characterized pain reduced function temporomandibular joint associated masticatory musculature prevalence united states twice high among women men conducted discovery genome wide association study gwas tmd participants cases controls hispanic community health study study latinos hchs sol promising single nucleotide polymorphisms snps tested meta analysis independent cohorts one replication cohort united states others germany finland brazil totaling tmd cases controls locus near sarcoglycan alpha sgca suggestive discovery analysis replicated tailed brazilian cohort discovery cohort sex stratified analysis identified additional genome wide significant loci females one lying upstream relaxin insulin like family peptide receptor rxp chromosome odds ratio replicated among females meta analysis tailed chromosome replicated among females tailed well replicated meta analysis sexes tailed novel locus genome wide level significance intron dystrophin gene dmd chromosome suggestive locus chromosome upstream transcription factor gene identified discovery cohort neither replicated sgca gene encodes sgca involved cellular structure muscle fibers along dmd forms part dystrophin glycoprotein complex functional annotation suggested several variants reside loci regulate processes relevant tmd pathobiologic processes
background gut microbiome consists highly diverse ecologic community microorganisms increasingly studied regarding role multiple sclerosis immunopathogenesis review critically examines literature investigating gut microbiome methods comprehensive search performed pubmed databases ectrims meeting abstracts literature relating gut microbiome controlled studies examining gut microbiome patients included review results identified studies predominantly case control design consistently found differences gut microbiome patients compared controls examine plausible mechanistic links differences immunopathogenesis discuss therapeutic implications findings conclusions review available literature reveals potential immunopathogenic links gut microbiome identifies avenues therapeutic advancement emphasizes need systematic study emerging field
background symptomatic sinus node dysfunction snd consists variety manifestations including tachycardia bradycardia syndrome atrial fibrillation commonly associated snd complicates management conditions paper reviews epidemiology pathophysiology clinical trial data investigating therapeutic approaches treatment patients snd methods authors reviewed articles published english describing epidemiology pathophysiology therapeutic approaches patients snd search conducted using pubmed keywords included sick sinus syndrome sinus node dysfunction atrial fibrillation pacing pulmonary vein isolation results snd affects one five patients lead anatomical electrophysiological remodeling atria including region sinoatrial node changes including atrial fibrosis altered calcium channel metabolism transformed gene expression demonstrated patients snd nonrandomized clinical trial data failed demonstrate whether pacing strategy reduce risk pulmonary vein isolation appears decrease episodes tachybrady syndrome sinus pauses conclusions snd affects one five patients pathophysiological derangements gene expression ion channel metabolism alterations myocardial architecture associated may lead anatomic electrical changes region sinoatrial node ablation may improve symptoms associated snd patients future randomized trials needed clarify epidemiology optimal management patients snd
keynote article coactivation bilingual grammars computational account code mixing goldrick putnam schwarz aimed provide framework would begin unify psycholinguistic formal grammatical approaches code mixing situated account within large body psycholinguistic phonetic evidence suggesting many conditions multiple representational elements simultaneously occupy varying degrees single position within linguistic structure presence blends multilingual cognition compatible many formal grammatical approaches assume mental representations necessarily discrete
offshore wind turbines take advantage vast energy resource open waters face structural integrity challenges specific operating environment require cost effective load alleviation solutions paper introduces computational methodology model based two three dimensional design load alleviation systems offshore wind turbines aero hydro servoelastic model formulated convenient state space representation coupling multi body composite beam description main structural elements unsteady vortex lattice aerodynamics morison description hydrodynamics aerodynamics require empirical corrections focuses control oriented approach modelling numerical results show trailing edge flaps actuated robust controller reduction dynamic loading due atmospheric turbulence achieved sectional model close reduction blade loads obtained complete three dimensional floating turbine
graph theoretic formulation sensitivity analysis multi domain dynamic systems presented article formulation linear graph used capture system topology graph theoretic formulation used generate system equations sensitivity equations simultaneously linear graph symbolic generation ensures automated accurate efficient generation sensitivity equations proposed method sensitivity analysis avoids differentiation complicated algebraic expressions corresponding equation swells using pre formed stored expressions combined according topology captured linear graph illustrate application graph theoretic sensitivity analysis multi domain systems electric motor driven slider crank mechanism automotive torque converter considered examples generation sensitivity equations demonstrated results validated using finite difference formulation also efficiencies generated equations gauged measuring associated computational costs finally features multi domain multibody systems pose unique challenges theory software implementation presented along brief description symbolic software platform used implement algorithm
gender differences explored pcl codings manifestation psychopathy female male patients admitted one four dutch forensic psychiatric hospitals four groups compared respect criminological characteristics historical violence risk factors psychiatric characteristics including incidents treatment lowered pcl cut score applied female additional manual fam vogel vries robbe van kalmthout place used define women psychopathy four groups women without psychopathy pcl women psychopathy pcl men without psychopathy pcl men psychopathy pcl overall found women men psychopathy show multiple similarities personal criminal histories also several gender differences women psychopathy compared men psychopathy committed fraud offended often relational frustration often diagnosed borderline personality disorder showed less physical violence manipulative self destructive behavior treatment overall women obtained lower scores pcl men predictive validity pcl physical violence treatment good men moderate women verbal violence included definition violence predictive validity pcl good female male sample implications study forensic practice discussed several directions future research provided
paper proposes new model method algorithms processing subject domain considers tuple set objects domain set connections objects set mass problems solved domain object represented essential attributes allows describe solve mass problems control state domain goal paper develop method algorithms allow find essential attributes domains described relational databases production systems production system build dependency graph attributes vertexes calculate vertexes value indicates many attributes found using particular vertex high ranked vertexes considered essential method based considering essential frequently accessed attributes relational database essential attributes objects domain allows define essential attributes domain
optical method developed estimate water transparency underwater visibility terms secchi depth follows remote sensing contrast transmittance theory major factors governing variation namely turbidity length attenuation coefficient beam attenuation coefficient diffuse attenuation coefficient obtained based band rationing techniques found band ratio remote sensing reflectance expressed contains essential information water column optical properties thereby positively correlates turbidity beam attenuation coefficient obtained linear relationship turbidity derive vertical diffuse attenuation coefficient estimated function reflectance ratio provides bio optical link chlorophyll concentration present algorithm applied modis aqua images results evaluated matchup comparisons remotely estimated situ coastal waters point calimere adjoining regions southeast coast india results showed pattern increasing shallow turbid waters deep clear waters statistical evaluation results showed percent mean relative error modis aqua derived situ values within close agreement achieved spatial contours modis aqua derived situ month january august promises model capability yield accurate estimates zsd coastal estuarine inland waters spatial contours included provide best data visualization measured modeled situ satellite derived products modeled satellite derived values compared measurement data yielded rmse mre modeled rmse mre satellite derived products
aim studies determinants psychosocial functioning first episode psychosis used predictors study examines effects multiple cognitive domains multiple symptoms psychosocial functioning methods total patients first episode psychosis assessed within months referral early psychosis treatment department four psychopathological subdomains positive negative symptoms depression anxiety five subdomains psychosocial functioning work study relationships self care disturbing behaviour general psychosocial functioning measured neurocognitive social cognitive factors identified principal component analyses pca measure cognitive battery stepwise backward regression models computed identify determinants psychosocial functioning results three neurocognitive four social cognitive factors identified pca largely independent psychopathology strongest associations cognitive factors anxiety higher levels negative symptoms poor general neurocognition poor general social cognition showed strongest associations impaired psychosocial functioning followed low verbal processing speed low emotion processing speed together factors accounted variance psychosocial functioning conclusions results suggest negative symptoms impaired neurocognition poor social cognition related psychosocial problems patients first episode psychosis none affective positive symptoms marked impact psychosocial functioning
paper describes possibility capture energy vertical movement ocean waves using gravitational electrical generator magnetic fluid cushion constructed permanent magnet magnetic fluid shell ocean waves action moving translation inside hermetically sealed tube elsevier science rights reserved
paper addresses design robust lyapunov based controller flexible joint electrically driven robots considering voltage control input proposed approach related key role electrical subsystem motors thus free mechanical subsystem actuator dynamics considered unmodeled dynamics main contribution paper prove closed loop system composed full nonlinear actuated robot dynamics proposed controller bibo stable actuator link position errors uniformly ultimately bounded stable agreement lyapunov direct method finite region state space also forms constructive conservative algorithm suitable choice gains pid controller analytical studies well experimental results produced using matlab simulink external mode control flexible joint electrically driven robot demonstrate high performance proposed control schemes
introduction imatinib mesylate used extensively first line treatment chronic myeloid leukemia cml however many studies documented morphological changes bone marrow biopsies produced imatinib therapy reference myelofibrosis aim document morphological changes produced bone marrow imatinib therapy materials methods longitudinal study followed philadelphia chromosome positive chronic myeloid leukemia chronic phase cml patients sequentially receiving imatinib period months haematologic parameters measured admission weeks month months months months morphologic changes bone marrow aspirate biopsy evaluated admission months months treatment accordance national comprehensive cancer network nccn guidelines results complete haematologic response chr seen month months months months respectively therapy noted patients showing chr months less likely show chr months beyond bone marrow aspirates biopsies showed reduction cellularity myeloid precursors regeneration erythroid precursors months significant decrease myelofibrosis value noted early months mild moderate hypoplasia noted biopsies within months pseudo gaucher cells benign lymphoid nodules also seen conclusion sequential analysis showed imatinib reduced grade myelofibrosis significantly value also prevented development myelofibrosis patients presentation hence imatinib effective used early course cml
contraception essential tool reproductive management captive species association zoos aquariums aza reproductive management center rmc gathers data contraception use provides recommendations although apes given oral contraceptive pills ocps least years published reports basic information pill administered formulations brands used effects physiology behavior report survey results characterizing ocp use bonobos pan paniscus housed north american zoos well information accumulated rmc contraception database females treated failures nine reversals commonly administered ocp formulation bonobos contained ethinyl estradiol norethindrone females combined oral contraceptives cocs given continuous active pill regimen hormone free interval least days allowed crushing pill mixing juice food common females cocs seldom experienced breakthrough estrus bleeding conditions sometimes observed females continuous cocs females cocs exhibited degree perineal swelling mean score commonly reported behavioral changes included less sexual behavior dominant females becoming subordinate negative effect mood appreciable change weight noted taken together results indicate ocps effective reversible contraceptive option bonobos used zoos sanctuaries limit reproduction zoo biol wiley periodicals inc
built data structures key contributor performance dynamic languages record data structures records one common advanced easily optimizable built data structures supported languages records may used object oriented fashion implement object orientation paper analyze records used different applications scheme dialect racket based data obtained suggest application existing optimization techniques records devise new one immutable boolean fields applied wide range record implementations dynamic languages apply optimizations records pycket implementation racket one exception microbenchmarks show two ten fold speed implementation plain racket
biologics novel therapeutic medications developed targeted therapy variety inflammatory conditions biologics currently investigated treatment chronic rhinosinusitis crs nasal polyps modulate specific inflammatory pathways involved pathogenesis disease investigations focused severe form disease namely crs nasal polyps hoped specific targeted therapies using biologics significantly modulate immune system offering disease control symptomatic relief review summarizes therapies used treat nasal polyps
background little known patterns medication use lifestyle counseling patients peripheral artery disease pad united states objectives authors sought evaluate trends medical therapy lifestyle counseling pad patients united states methods data outpatient visits among patients pad obtained national ambulatory medical care survey national hospital ambulatory medical care survey nationally representative assessment office based hospital outpatient department practice trends proportion visits medication use antiplatelet therapy statins angiotensin converting enzyme inhibitors aceis angiotensin receptor blockers arbs cilostazol lifestyle counseling exercise diet counseling smoking cessation evaluated results year period average annual number ambulatory visits united states pad across visits mean age years female non hispanic white comorbid coronary artery disease cad present visits medication use cardiovascular prevention symptoms claudication low antiplatelet therapy standard error statin acei arb cilostazol visits exercise diet counseling used visits among current smokers pad smoking cessation counseling medication used visits significant change medication use lifestyle counseling time compared visits patients pad alone comorbid pad cad likely prescribed antiplatelet therapy odds ratio confidence interval statins acei arb smoking cessation counseling conclusions use guideline recommended therapies patients pad much lower expected highlights opportunity improve quality care high risk patients american college cardiology foundation
multiple effective interventions emerge reduce spread hiv need implement disseminate programs cost effectively expanding service delivery integration peer supporters benefits peer support well established however knowledge peer counseling initiatives remain limited pilot study tested feasibility fidelity acceptability motivational interviewing counseling training individuals living hiv serve peer counselors order address medication adherence safer sex adapted safetalk evidence based intervention previously delivered health professionals reduce risky sexual behaviors among people living hiv trained six peers day program hours total month period used combination training observation pre posttests debriefing motivational interviewing treatment integrity miti scale assess implementation training results suggest program feasible positive acceptability however fidelity poor participants dedicated enthusiastic training able learn skills demonstrate spirit difficulty reflecting moving away giving direct advice training challenges successes discussed
background perception patients needs support sensitive communication psychosocial stress represent new exacting tasks nursing staff midwives social workers physicians obstetrics part good start family gustaf learning teaching project university hospital able interview parents experiences intervention objective evaluation process establishing contacts communication professionals obstetrics support offered perspective parents methods qualitative guided interviews seven families one year delivery results problem areas reported parents predominately related increased parental care feeling overwhelmed addition social stress core themes communication addressed entry conversations remembered negatively advice perceived improper patronizing stigmatizing positively professionals listened sensitively provided tangible support conversations increased stress relating assistance support parents reported positive negative experiences justness reliability emerged particularly important topics discussion attendance families around time delivery poses varying demands upon hospital staff necessarily keeping traditional professional attitudes competencies careful attention personal physical emotional well mothers newborns non stigmatizing entry conversations justness support avoiding inconsistencies within institution network appear great importance
making use favourable local circumstances interdisciplinary team content experts educational researchers game designers secondary school teachers formed using design research approach team simultaneously developed tested serious game teaching electrical circuits effective classroom practice using project comprised two rounds first round open inquiry teaching strategy used game observed strong impact students understanding though desired way basis evaluation additional expert review game redesigned simultaneously classroom practice improved accordingly extend teacher guide developed supporting teachers switching free gaming episodes classroom episodes discussion reflection second round strong impact students conceptual understanding electrical circuits observed students showed fewer misconceptions moreover students spontaneously reported game helped understand subject conclude multi disciplinaire collaboration essential result teachers played critically role connecting development game classroom practice design research approach taken greatly helped keep teams focus educational output accordingly educational expert appeared best positioned play leading role also concluded suitable mental model coherently represented game structure layout looks included serious game may significantly contribute students conceptual understanding
hypersexuality extreme normophilic sexual urges behaviors controversial construct recently considered candidate disorder dsm rejected also rejected inclusion section iii conditions study nonetheless found important predictor recidivism among sex offenders continues discussed widely literature present study investigated developmental roots construct sample adult male sexual offenders administered multidimensional assessment sex aggression physical psychological sexual abuse experiences estimated using several scales early development psychological abuse childhood adolescence especially father found prominent predictor sub sequent hypersexual thoughts behaviors accumulation abuse types however also associated monotonic increase latent trait hyper sexuality consequences results conceptualizations construct discussed
fuel cell lithium ion battery hybrid power system hps gradually becomes powerful energy source future paper presents digital boost converter current regulation hps dual battery energy storage unit esu digital boost converter regulates current order control power generation simulations conducted psim environment digital controller implemented microchip dspicfjgs bit microcontroller experimental results show efficiency power conversion reach
due lack source network ioad global perception multiple time scale situation awareness current distribution network meet requirements active distribution network adn active control active management adn situation awareness system based distributed monitoring multi source information fusion proposed paper constructing multi level distributed monitoring system based internet things lot technology monitoring objects distribution network expanded achieve global awareness spatial scale light randomness volatility risk distribution network operation necessary enhance observability situation awareness time scale thus situation awareness technology distribution network based multi source information fusion provided constituted multi source information fusion source load forecasting fast simulation analysis risk assessment warning visualization modules finally operation cockpit visualization technology enables operators efficiently capture accurate distribution network security situation trend adn situation awareness system demonstration project currently carried state grid jiangsu power company actual operation indicates effectively enhance operation situation awareness risk early warning capability
effort minimize harmful effects violent yearlong intervention undertaken children grades classroom based intervention consisted brief lessons emphasized many ways television distorts violence hypothesized intervention resulted reduction children viewing violent well less identification violent characters intervention successful girls boys receiving intervention judged classmates reduced behavioral aggression following intervention importance research project provides encouraging evidence literacy programs reduce harmful effects violent young viewers elsevier inc rights reserved
growing body international research demonstrates supportive teacher student relationships multiple positive educational effects scandinavia concept relational competence increasingly used define teacher ability develop good relationships overall purpose article contribute field adopting interactionist perspective drawing chiefly shibutani also mead scheff article aims examine teacher student relationship constructed nonverbal communication discuss implications regarding teachers relational competence situated teaching detailed transcript classroom episode interpreted analysed using shibutani concepts analysis reveals two parallel relational matrices one conventional interpersonal concluding section argued relationship two matrices plays important role understanding teachers relational competence relationally competent teacher takes responsibility actions educator conventional system fellow interpersonal system expressed differently relational incompetence means overemphasizing one system expense
staphylococcal colonization human skin ubiquitous particular species frequent different body sites whereas staphylococcus epidermidis isolated skin every individual tested staphylococcus aureus isolated healthy individuals factors drive staphylococcal speciation niche selection skin incompletely defined show aureus inhibited greater extent epidermidis sebaceous lipid sapienic acid supporting role skin antimicrobial selection skin staphylococci used rna seq comparative transcriptomics identify sapienic acid survival responses aureus epidermidis consistent membrane depolarization mode action sapienic acid species shared common transcriptional response counteract disruption metabolism transport species differed regulation saers vrars regulons aureus upregulated urease operon transcription epidermidis upregulated arginine deiminase oxygen responsive nreabc nitrogen regulation system nitrate nitrite reduction pathways role aureus acme chromosomal arginine deiminase pathways sapienic acid resistance determined mutational studies speculate ammonia production could contribute sapienic acid resistance staphylococci
background macro thyrotropin tsh high molecular weight form tsh cases macro tsh tsh complexed immunoglobulin study undertaken characterize macro tsh methods blood samples taken patients subclinical hypothyroidism screened presence macro tsh polyethylene glycol method confirmed gel filtration chromatography tsh receptor antibody quantified electrochemiluminescence immunoassay binding studies performed using human tsh specificity anti tsh autoantibodies tested displacement experiments using excess amounts unlabeled related peptides macro tsh serum tsh levels evaluated twice one four year interval results sixteen patients females males aged years diagnosed macro tsh none patients macro tsh tested positive tsh receptor antibody judging affinity binding capacity anti tsh autoantibodies two classes binding sites identified regarding specificity anti human tsh beta autoantibodies partially cross reactive bovine rat tsh beta also autoantibodies human glycoprotein common subunit among human tsh luteinizing hormone follicle stimulating hormone macro tsh persisted patients could reevaluated one four year interval first evaluation serum tsh levels returned normal remaining two patients whose macro tsh disappeared conclusions concluded anti human tsh autoantibodies major cause macro tsh macro tsh may persist long time
article presents parallel algorithm model nonlinear dynamic interactions ultrasonic guided waves fatigue cracks local interaction simulation approach lisa developed capture contact impact clapping phenomena wave crack interactions based penalty method initial opening closure distributions considered approximate rough crack microscopic features coulomb friction model integrated capture stick slip contact motions crack surfaces lisa procedure parallelized via compute unified device architecture cuda enables parallel computing powerful graphic cards explicit contact formulation parallel algorithm well gpu based implementation facilitate lisa high computational efficiency conventional finite element method fem article starts theoretical formulation numerical implementation proposed algorithm followed solution behavior study numerical verification commercial finite element code numerical case studies conducted lamb wave interactions fatigue cracks several nonlinear ultrasonic phenomena addressed classical nonlinear higher harmonic response successfully captured nonlinear mode conversion thickness half thickness fatigue crack investigated threshold behaviors induced initial openings closures rough crack surfaces depicted proposed contact lisa model elsevier rights reserved
large model repositories common objects ubiquitous increasingly used computer graphics computer vision analysis synthesis tasks however images objects real world richness appearance repositories capture largely existing models untextured work develop automated pipeline capable transporting texture information images real objects models similar objects challenging problem object texture seen photograph distorted many factors including pose geometry illumination geometric photometric distortions must undone order transfer pure underlying texture new object model instead using problematic dense correspondences factorize problem reconstruction set base textures materials illumination model object image exploiting geometry similar model reconstruct certain reliable texture regions correct illumination full texture map recovered applied model method allows large scale unsupervised production richly textured models directly image data providing high quality virtual objects scene design photo editing applications well wealth data training machine learning algorithms various inference tasks graphics vision
background despite positive evaluation various caregiver interventions past decades intervention protocols translated delivery service contexts purpose study train care counsellors statutory long term care insurances problem solving evaluate approach additional component statutory care counselling germany methods pragmatic cluster randomized controlled trial sites care counsellors randomly assigned provide either routine counselling plus additional problem solving caregivers routine counselling alone counsellor training comprises initial day training follow day months biweekly supervision contacts psychotherapist months phone agreed minimum counselling intensity one initial face face contact including caregiver assessment least one telephone follow contact caregivers positively screened significant strain role followed months baseline assessment main outcome caregivers depressive symptoms discussion unclear expected low amount additional counselling time sufficient yield additional effects caregiver depression also unclear additional problem solving component yields synergies routine counselling based information case management different potential individual organisational barriers consistent intervention delivery like gratification participation time extra work internal motivation participate
paper presents fully digital control soft start mechanism coefficients optimization power converters soft start phase ladder reference voltage steps gradually make inductor current ramp smoothly overshoot voltage minimized proposed coefficients distribution simulation results show massive inductor current well avoided soft start process proposed soft start mechanism occupies chip area umxum
interactive database exploration key task information mining relational databases long used critical infrastructure component access analyze large volumes data variety applications including hoc analytics big data large scale data warehouses support business intelligence tools services scientific data exploration aid users databases developed querie system personalized query recommendations similarly traditional recommender systems querie continuously monitors user querying behavior finds matching patterns system query log identifying similar users subsequently users queries used recommend queries current user may find useful previously shown employing different neighborhood based collaborative filtering techniques exists trade computational efficiency accuracy paper extend previous work querie framework address scalability desirable characteristic applications rely mining big data latent factor collaborative filtering models shown address scalability problem traditional rating based recommender systems without much compromise recommender system accuracy work explore use latent factor models instead ratings input consists database query log data show experimentation case rating based recommender systems techniques offer scalability prediction accuracy database query recommendations domain outperforming neighborhood based approaches
organophosphate flame retardants pfrs commonly used alternatives banned polybrominated diphenyl ethers pbdes ubiquitously detected indoor dust pfrs potentially hazardous respiratory health via inhalation house dust dendritic cells dcs crucial immunological defense pathogens airways respiratory allergy however aberrant immune response induced innocuous proteins like house dust mite allergens study examined whether exposure pfrs triphenylphosphate tphp tris dichloroisopropyl phosphate tdcipp affected activation maturation dcs steady state exposure house dust mite allergens hdm bone marrow derived dendritic cells bmdcs exposed concentration range pfr without hdm vitro analyze effect expression major histocompatibility complex class mhcii stimulatory molecules cytokine production concentrations tphp tdcipp cytotoxic bmdcs cytotoxic concentrations tphp exposure induced activated phenotype steady state dcs hdm exposed dcs acquired tolerogenic phenotype contrast tdcipp exposure effect steady state dcs suppressed expression mhcii costimulatory molecules production hdm exposed dcs cytotoxic concentrations induced anti oxidant enzyme hemeoxigenase marker oxidative stress results demonstrate pfrs immunotoxic dcs suggest necessity evaluate effects immune system cellular level risk assessment alternative flame retardants authors published elsevier ltd
aim aim study test psychometric properties salutogenic health indicator scale shis adolescent population methods investigation performed among swedish students aged years girls shis assessed respondent acceptability psychometric properties evaluated according classical test theory regarding unidimensionality targeting reliability external construct validity results adolescents found easy complete questionnaire completed average minutes exploratory factor analysis based polychoric correlations identified one factor supporting instrument unidimensionality floor ceiling effects reliability estimates yielded cronbach alpha value test retest reliability week interval coefficients total shis score item scores spearman correlations variables based priori expectations self rated general health depressive symptoms anxiety sleep problems conclusions observations support acceptability psychometric properties shis brief unidimensional assessment tool salutogenic health adolescents studies using modern test theory needed better understand measurement properties shis including functioning response categories comparability adolescents adults
background nasal continuous positive airway pressure ncpap effective method ventilation newborns respiratory distress syndrome rds using appropriate nasal skin care protocol identical prevention reduction nasal skin breakdown receive ncpap study aimed investigate effectiveness evidence based clinical care protocol nasal skin integrity preterm newborns receive ncpap materials methods randomized controlled trial used conduct study cohort preterm newborns gestational age weeks receiving nasal continuous positive airway pressure ncpap rds neonatal intensive care unit university teaching hospital selected perform study randomly assigned protocolized nasal skin care group group receiving routine care group nasal skin integrity preterm neonates measured daily basis days using neonatal skin condition scale nscs hours placement ncpaps groups results intervention control group included neonates neonates control group neonates intervention group male repeated measures analysis showed nscs scores significantly lower intervention group receiving nasal skin care accordance protocol control group receiving routine nasal skin care conclusion study protocolized care reduced nasal skin breakdown preterm newborns receiving ncpap therefore used effective method nasal skin care neonates treated ncpap
objective describe safety ulipristal acetate emergency contraception study design postmarketing pharmacovigilance data collection results total women experienced adverse drug reactions frequent pregnancies nausea abdominal pain vomiting headache dizziness metrorrhagia menses delay breast symptoms including data clinical trials pregnancies reported total known outcome live births newborns miscarriages induced abortions ectopics ongoing conclusions safety concern emerges sizable database reported adverse reactions following ulipristal acetate exposure among varying ethnicities regions postapproval data confirm safety profile described clinical trials implications use ulipristal acetate emergency contraception variety settings among diverse populations indicate safe without unexpected serious adverse events elsevier inc rights reserved
natural phenomena simulation attracts lot research attention interest virtual reality simulation liquid become research focus computer graphics computational physics difficulties dynamic modelling high computational complexity introduce main research achievements recent years regard liquids common natural phenomenon hybrid modelling approach dynamic liquid simulation proposed followed surface reconstruction method using simulated results particle based fluid simulation surface construction one procedure contour implicit function determines isosurface scalar field describe adaptive polygonisation approach adaptively constructing unconstrained octree structure reduce excessive subdivision required traditional methods like marching cubes dual marching cubes applied perform surface extraction new grid topologically dual octree structure experiment shows advantages approach generating satisfactory effects without excessively fine grained grid structure satisfactory visual effect achieved application used computer games movie making virtual simulation medical areas
severe water pollution among top policy priorities china india paper undertakes comparative case analysis examine efforts combating river pollution two major rivers yangtze china ganga india analysis suggests efforts combating river pollution two asian giants encountered substantial challenges lack comprehensive legal mechanisms control pollution basin level lack coordination among multiple government agencies significant gaps policy implementation analysis also points considerable differences china india institutional structure regulatory approaches policy instruments dealing river pollution
background generalized ligamentous laxity defined increased range joint motion compared general population predisposing factor sports injuries especially lower extremities nevertheless little evidence relationship generalized ligamentous laxity sports injuries upper extremities objectives evaluate relationship generalized ligamentous laxity acute chronic shoulder injuries athletes patients methods study comprised volunteer athletes history least six months sports activities shoulder injury three years prior participation study athletes divided two groups without generalized ligamentous laxity acute chronic shoulder injuries shoulder pain shoulder instability functional status assessed via quickdash measure determined compared two groups value less considered significant results group ligamentous laxity consisted participants group without ligamentous laxity consisted participants athletes group shoulder pain chronic shoulder injuries shoulder instability less functionality group fracture considered acute injury groups athletes generalized ligamentous laxity would acute shoulder injuries conclusions generalized ligamentous laxity important predisposing factor acute chronic shoulder injuries athletes prescreening programs beginners rehabilitation shoulder programs sports athletes high risk strongly recommended
recent years increasing interest adopting synchronous reluctance machines several applications due two main factors first increasing highly variable cost rare earth permanent magnet ndfeb smco second requirement efficient machines respect induction machines general applications however drawback synchronous reluctance machine low power factor drawback compensated assisting machine means proper volume material generally ferrite introduced rotor flux barriers flux saturates rotor iron bridges increases power factor machine corresponds decrease volt amps ratings inverter adds flux torque component paper investigates select optimal amount ferrite magnet assisted reluctance machine
distance measures part parcel many computer vision algorithms underlying assumption existing distance measures feature elements independent identically distributed however real world settings data generally originate heterogeneous sources even possess common data generating mechanism since sources identically distributed necessity assumption identical distribution inappropriate use statistical analysis show feature elements local image descriptors indeed non identically distributed test effect omitting unified distribution assumption created new distance measure called poisson binomial radius pbr pbr bin bin distance accounts dispersion bin bin information pbr performance evaluated twelve benchmark data sets covering six different classification recognition applications texture material leaf scene ear biometrics category level image classification results experiments demonstrate pbr outperforms state art distance measures data sets achieves comparable performance rest suggesting accounting different distributions distance measures improve performance classification recognition tasks
tools estimate survival eprognosis developed general cancer populations older patients breast cancer accurate overall survival estimates would facilitate discussions adjuvant therapies secondary analyses performed data two parallel breast cancer studies calgb alliance nct calgb alliance nct included patients age years older complete baseline quality life data estimated versus observed cause two year mortality rates compared eprognosis score calculated based age sex daily function derived eortc qlq eprognosis scores range higher scores indicating worse prognosis based mortality community dwelling elders categorized three groups observed mortality rates estimated using kaplan meier methods patient mean age years range stage iia disease patients classified eprognosis good prognosis poor prognosis two year observed mortality rates significantly lower eprognosis estimates patients scoring trend seen scores eprognosis tool modestly overestimates mortality rate older breast cancer patients enrolled two cooperative group studies tool estimates non cancer mortality risk based readily available clinical information may inform adjuvant therapy decisions validated non clinical trial populations
oxidative stress associated decreased female fertility adversely affects prenatal development mammalian cells developed network enzymatic non enzymatic antioxidant defence systems prevent oxidative stress little attention paid antioxidative pathways placentas normal disturbed pregnancies leaving gap knowledge role antioxidants control foeto placental development challenges studying early human pregnancy partly overcome designing animal models abnormal pregnancy aimed determine whether antioxidant status placentas cba dba abortion prone pregnant mice differed normal pregnant mice foetal placental weight ratio lower abortion prone matings compared non abortion prone matings increased placental malondialdehyde mda content end products lipid peroxidation concomitants alterations placental antioxidants namely copper zinc containing superoxide dismutase sod manganese containing sod glutathione peroxidases gpx glutathione reductase catalase cat activities may involved placental foetal growth restriction show placental oxidative stress linked poor prenatal development pregnancy losses cba dba mice matings animal model may useful evaluation nutritional antioxidant therapies oxidative stress associated prenatal developmental disorders
intestinal epithelial barrier function impaired irritable bowel syndrome patients claudins highly expressed cells tight junctions involved intestinal epithelial barrier function expression pattern tight junction proteins diarrhea predominant irritable bowel syndrome fully elucidated therefore recruited diarrhea predominant irritable bowel syndrome patients healthy controls expression tight junction related proteins examined ileal cecal rectal mucosa diarrhea predominant irritable bowel syndrome patients using real time pcr immunofluorescence claudin expression high ileum diarrhea predominant irritable bowel syndrome patients claudin expression cecum rectal mucosa control diarrhea predominant irritable bowel syndrome patients similarly expression clauidn claudin jam occludin ileal cecal rectal mucosa change control diarrhea predominant irritable bowel syndrome samples infiltration eosinophil mast cells mucosa ileum cecum rectum evaluated using immunohistochemical staining affected diarrhea predominant irritable bowel syndrome claudin expressed apical side villi crypts ileal mucosal epithelial cells clauidn expression upregulated diarrhea predominant irritable bowel syndrome patients may contribute pathogenesis condition
elevation bradykinin level attacks hereditary angioedema due inhibitor deficiency inh hae well known previously demonstrated endothelin level also increases inh hae attacks although potent vasoactive peptides vasoregulatory aspect pathomechanism inh hae yet investigated hence studied levels vasoactive peptides controls inh hae patients well evaluated changes inh hae attacks levels arginine vasopressin avp adrenomedullin adm measured plasma inh hae patients inter attack periods control subjects using brahms kryptor technologies inh hae patients levels vasoactive peptides compared blood samples obtained attacks inter attack periods avp adm levels similar inter attack samples inh hae patients samples controls although cardiovascular risk effect levels vasoactive peptides groups levels three vasoactive peptides increased inh hae attacks moreover levels adm well changes attacks significantly correlated study demonstrated vascular regulation vasoactive peptides affected inh hae attacks results suggest cooperation several vasoactive peptides may necessary counterbalance actions excess terminate attacks may reveal novel pathophysiological aspect inh hae
systemic lupus erythematosus sle systemic autoimmune disease facilitated aberrant immune responses directed cells tissues resulting inflammation organ damage majority patients genetic predisposition accompanied additional factors conferring disease expression exact molecular mechanisms remain elusive epigenetic alterations immune cells demonstrated play key role disease pathogenesis dysregulation gene expression since epigenetic marks dynamic allowing cells tissues differentiate adjust influenced environmental factors also targeted therapeutic interventions summarize reports dna methylation patterns sle underlying molecular defects effect immune cell function discuss potential dna methylation biomarker therapeutic target sle
empathy involves able understand respond others emotional experiences whilst deficits empathy observed frontotemporal dementia extent empathy disrupted dementia syndromes predominant language impairment remains unclear current study investigated cognitive affective empathy two non fluent primary progressive aphasia syndromes progressive non fluent aphasia pnfa logopenic progressive aphasia lpa informants pnfa lpa patients completed interpersonal reactivity index iri regarding patients capacity empathy preand post disease onset twenty four healthy control participants completed self rated iri comparison post disease empathy capabilities within group analyses revealed reduced cognitive empathy increased personal distress patient groups addition lowered affective empathy reported pnfa similar trend observed lpa interestingly reduced affective empathy associated greater carer burden lpa group analyses revealed reduced cognitive empathy patient groups relative controls current study first document empathy changes pnfa lpa offering insight social cognitive deficits experienced syndromes future neuroimaging studies needed identify underlying neural correlates mechanisms driving empathy deficits pnfa lpa
study aims explore role microrna mir tlr regulation cell proliferation human epidermal keratinocytes heks psoriasis twenty eight patients diagnosed psoriasis vulgaris selected case group lesional non lesional skin tissues collected control group consisted patients underwent plastic surgery healthy skin tissues collected real time quantitative fluorescence polymerase chain reaction qpcr situ hybridization immunohistochemistry used detect expressions mir tlr heks healthy skin psoriatic lesional skin non lesional skin respectively untranslated region utr tlr combined mir verified dual luciferase reporter assay western blotting bromodeoxyuridine applied corresponding detection tlr expression cell mitosis expression mir heks psoriatic lesional skin less healthy skin psoriatic non lesional skin psoriatic lesional non lesional skin tlr positive cell rates number positive cells per square millimetre higher healthy skin dual luciferase reporter assay verified mir targets tlr heks transfected mir mimics decreased expression tlr along decrease mitotic indexes brdu labelling indexes however heks transfected mir inhibitors showed increased tlr expression mitotic indexes brdu labelling indexes heks transfected mir inhibitors sitlr decreased mitotic indexes brdu labelling indexes results indicate mir negatively regulate proliferation heks psoriasis targeting tlr
asthma united states become important public health issue many physicians regulators scientists elsewhere expressing concern criterion air pollutants contributed rising tide asthma cases symptoms paper studies recent associations self reported asthma experiences potential predictors including age sex income education smoking county level average annual ambient concentrations ozone fine particulate matter levels recorded environmental protection agency adults years old older survey data available centers disease control prevention cdc behavioral risk factor surveillance system brfss also examine associations variables self reported heart attack stroke experience three health outcomes positively associated young divorced women low incomes greatest risk asthma especially ever smokers income important confounder relations example logistic regression modeling positively associated stroke risk heart attack risk regressed sex age ever smoking status regressed variables income data set significantly negatively associated asthma risk regression models decrease corresponding increase probability asthma possibly confounding smoking negatively associated positively associated asthma risk variety non parametric methods used quantify associations explore potential causal interpretations
compressed sensing demonstrates sparse signals estimated underdetermined linear systems distributed dcs reduces number measurements considering joint sparsity within signal ensembles dcs jointly sparse signals applications multisensor acoustic sensing magnetic resonance imaging multiple coils remote sensing array signal processing multimeasurement vector mmv problems consider estimation jointly sparse signals dcs framework two related mmv settings studied first setting signal vector measured different independent identically distributed measurement matrix second setting signal vectors measured matrix replica analysis performed two mmv settings minimum mean squared error mmse turns identical settings obtained function noise variance number measurements showcase application mmv models mmse complex problems real complex measurement matrices also analyzed multiple performance regions mmv identified mmse behaves differently function noise variance number measurements belief propagation signal estimation framework often achieves mmse asymptotically phase transition identified phase transition verified numerical results separates regions achieves mmse suboptimal numerical results also illustrate signal vectors jointly sparse signal ensemble lead better phase transition
paper presents new approach path following control design autonomous underwater vehicle auv narmax model auv derived first parameters adapted online using recursive extended least square algorithm adaptive propotional integral derivative pid controller developed using derived parameters accomplish path following task auv gain parameters pid controller tuned using inverse optimal control technique alleviates problem solving hamilton jacobian equation also satisfies error cost function simulation studies pursued verify efficacy proposed control algorithm obtained results envisaged proposed narmax model based self tuning adaptive pid control provides good path following performance even presence uncertainty arising due ocean current hydrodynamic parameter
myriad controversies embroiling mental health field heightened lead release dsm merit close analysis field epistemological underpinnings using dsm starting point paper develops overview entire mental health field beginning history field recent crises troubles past external crisis compared contemporary internal crisis effort examine crises recurred internal dynamics field assessed applying kuhn paradigmatic framework crises appraised situate differences natural sciences mental health field next foucauldian analysis examines functioning field power body disproportionate comparison scientific grounding followed investigating field combination contested scientific grounding significant power latourian consideration assumptions meaning behind mental health field deployment science includes scrutinizing history classification post traumatic stress disorder ptsd paper closes assessing field potential address issues effectively
objective article present framework couples cloud high performance computing parallel map projection vector based big spatial data past years witnessed tremendous growth variety high volume spatial data big spatial data map projection often needed example apply big spatial data large scale spatial analysis modeling approaches require common coordinate system however due size data algorithmic complexity map projections transformation big spatial data alternative projections represents pressing computational challenge recent advancement cloud computing high performance computing offers potential means addressing computational challenge parallel map projection framework presented study based layered architecture couples capabilities cloud computing high performance computing accelerated graphics processing units use large lidar data example vector based big spatial data investigate utility parallel map projection framework experimental results reveal framework provides considerable acceleration projecting vector based big spatial data coupling high performance cloud computing complement suggested solution efficient processing analysis big spatial data elsevier ltd rights reserved
facilitate effective assessment stress related bridge performance safety stress level buffeting analysis long span cable supported bridge necessary stress level buffeting analysis requires knowledge characteristics distributed aerodynamic forces surfaces bridge deck paper first presents formulation distributed aerodynamic forces surfaces bridge deck based quasi steady theory characteristics distributed aerodynamic forces pressure coefficients pressure admittances span wise pressure coherences introduced formulation consideration different characteristics incident signature turbulences empirical mode decomposition adopted separate effects distributed aerodynamic forces wind tunnel pressure tests sectional motionless bridge deck model conducted identify characteristics distributed aerodynamic forces surfaces stonecutters cable stayed bridge twin box bridge deck case study results indicate separation incident signature turbulence effects necessary proposed framework feasible although works need done towards complete stress level buffeting analysis elsevier ltd rights reserved
objective present study examines connection timing size supplemental nutrition assistance program snap benefits occurrence emergency room visits hypoglycaemia condition highly sensitive short term changes nutritional intake design used administrative data missouri snap medicaid identify timing issuance benefit size snap timing claims hypoglycaemia estimated probability submitting claim hypoglycaemia function calendar week snap benefit week size snap benefit models controlled individual demographic characteristics setting missouri snap caseloadfrom january december linked adult medicaid claims data time period subjects claims submitted medicaid results results indicated evidence snap benefit cycle monthly cycle claims hypoglycaemia however analysis find claims hypoglycaemia related size snap benefit conclusions results suggest generous snap benefits help households avoid nutritional fluctuations quality quantity food might result low blood sugar thus necessitating fewer visits hypoglycaemia
global functional brain network graph suitable characterizing brain states local analysis connectivity brain regions therefore graph theoretic approaches natural methods use studying brain however conventional graph theoretical analyses limited due lack formal statistical methods estimation inference example concept correlation two vectors graphs yet defined thus introduction notion correlation graphs becomes necessary better understand brain sub networks interact develop framework infer correlation graphs one may assume generated models parameters models random variables possible define two graphs independent random variables representing parameters independent real world however model rarely known consequently parameters estimated analyzing graph spectrum shown spectral radius highly associated parameters graph model based framework correlation inference graphs constructed approach illustrated functional magnetic resonance imaging data subjects comprising controls individuals diagnosed autism spectrum disorder asd results show correlations default mode control default mode somatomotor default mode visual sub networks higher individuals asd controls elsevier rights reserved
modern information knowledge society every citizen stands benefit advanced ict smart techniques however proportion benefits many side effects also come typical side effects copyright infringement hacking cyber bullying internet addiction etc internet addiction occur levels also cause serious social problems unless appropriate prevention treatment programs provided national level purpose paper investigate correlation internet addiction school age groups achieve purpose extensive national survey works national information society agency korea nia analyzed based results thorough statistical analysis concluded meaningful correlation internet addiction school age groups
ongoing search new monoamine oxidase mao inhibitors five coumarin derivatives eight flavonoids isolated roots angelica gigas nakai scutellaria baicalensis georgi respectively phytochemicals decursin found potently selectively inhibit human mao value mao belonged lowest group herbal sources similar toloxatone marketed drug wogonin effectively inhibited mao mao respectively furthermore compounds decursinol angelate baicalein observed selectively moderately inhibit mao addition compound reversibly competitively inhibited mao compound also competitively inhibited mao mao respectively molecular docking simulation revealed interacts asn residue mao asn residue mao formation hydrogen bond findings suggest compounds considered new potent reversible mao inhibitors useful lead compounds developments mao inhibitors treatment disorders like depression parkinson disease alzheimer disease elsevier rights reserved
literally hundreds electric motor manufacturers choose sorting options find best value daunting task paper draws author forty plus years experience share practical methods comparing motors purchase interwoven paper suggestions techniques improving designs motors already service areas interest include electrical windings bearings rotor designs ventilation balancing
numerical model used estimate service life clogging gravel leachate drainage layers filter separator layer used municipal solid waste landfills filter separator layer waste drainage layer shown reduce leachate strength entering gravel drainage layer extend time takes clog drainage layer point leachate level exceeds maximum design value service life filter layer shown far significant effect extending service life pea gravel used drainage layer less effect coarse gravel used cases examined although benefit filter separator layer achieved using thick needle punched nonwoven geotextile geotextile may sufficient many practical purposes similar examined results modeling leachate collection systems filter separator layers subjected constant variable leachate strength show characteristics leachate entering drainage layer substantially affect service life drainage layer high strength leachate entering systems limited time early life acid phase landfill greatly reduce service life leachate drainage layer
background relative performance semi quantitative amyloid positron emission tomography pet cerebrospinal fluid csf markers diagnosing alzheimer disease predicting cognitive evolution patients mild cognitive impairment mci still debated methods subjects alzheimer disease neuroimaging initiative complete baseline cognitive assessment mini mental state examination clinical dementia rating cdr alzheimer disease assessment scale cognitive subscale adas cog scores csf collection amyloid beta beta tau phosphorylated tau florbetapir scans included cross sectional cohort among patients mci substantial memory complaints constituted longitudinal cohort followed months pet amyloid deposition quantified using relative retention indices standardised uptake value ratio suvr respect pontine cerebellar composite reference regions diagnostic prognostic performance based pet csf evaluated using roc analysis multivariate linear regression survival analysis cox proportional hazards model results cross sectional study included participants revealed pontine composite suvr values better classifiers auc diagnostic accuracy csf markers auc accuracy beta tau respectively suvr strong independent determinant cognition multivariate regression whereas beta tau also determinant lesser degree among patients longitudinal study converted within months optimal suvr thresholds differentiate converters quite similar cross sectional study composite suvr best classifier auc sensitivity specificity multivariate regression baseline cognition cdr adas cog main predictor subsequent cognitive decline pontine composite suvr moderate independent predictors final status cdr adas cog progression rate whereas baseline csf markers marginal influence adjusted hrs conversion pet profile beta profile tau profile conclusions semi quantitative amyloid pet appears powerful csf markers grading mci prognosis terms cognitive decline conversion
past centuries men mainly looked increase production energy order develop industry means transport quality life since recent energy crisis researchers industrials looked mainly manage energy better way especially increasing energy system efficiency context explains growing interest thermoelectric generators today thermoelectric generators allow lost thermal energy recovered energy produced extreme environments electric power generated remote areas microsensors powered direct solar thermal energy also used produce electricity review begins basic principles thermoelectricity presentation existing future materials design optimization generators addressed finally paper developed exhaustive presentation thermoelectric generation applications covering electricity generation extreme environments waste heat recovery transport industry domestic production developing developed countries micro generation sensors microelectronics solar thermoelectric generators many recent applications presented well future applications currently studied research laboratories industry main purpose paper clearly demonstrate almost anywhere industry domestic uses worth checking whether teg added whenever heat moving hot source cold source elsevier ltd rights reserved
objectives standardize diagnostic investigations myeloproliferative neoplasms mpns increase homogeneity patient care streamline diagnostic approaches efficient cost effective manner methods development canadian expert consensus recommendations diagnosis mpns began review following clinical evidence daily practice existing treatment guidelines availability diagnostic tools group member assigned specific topic discussed entire group several consensus meetings results document provides canadian mpn group recommendations proposed diagnostic algorithms background evidence upon decisions made conclusions standardization diagnostic investigations increase homogeneity patient care provide foundation future clinical research rapidly evolving therapeutic area streamlining diagnostic approaches efficient cost effective manner also result significant cost saving health care system
background combination therapy prednisone etanercept may induce earlier improvement disease activity disease modifying anti rheumatic drug dmard naive non systemic juvenile idiopathic arthritis jia patients present three months clinical outcome initial treatments best kids study methods included patients randomized either initial dmard monotherapy sulfasalazine ssz methotrexate mtx initial mtx prednisolone bridging initial combination mtx etanercept percentage inactive disease adjusted acr pedi jadas weeks treatment intention treat analysis side effects reported results patients girls arm arm arm median interquartilerange age years included ana positive oligo articular disease polyarticular jia psoriatic arthritis baseline median iqr acrpedi scores vas physician vas patient esr active joint count limited joint count chaq score arm started mtx ssz months aacr pedi reached aacr pedi reached arms toxicity similar serious adverse events reported conclusion months treatment randomized trial patients recent onset jia achieved significantly clinical improvement aacrpedi initial combination therapy mtx etanercept initial mtx ssz monotherapy
objective investigate whether risperidone improves social cognitive impairments executive dysfunction people schizophrenia methods fifty six patients met diagnostic statistical manual mental disorders fifth edition diagnostic criteria schizophrenia allocated risperidone treatment group rtg typical antipsychotic treatment group tatg twenty eight healthy volunteers recruited normal control group ncg positive negative syndrome scale interpersonal perception task ipt wisconsin card sorting test wcst rated baseline weeks treatment risperidone typical antipsychotics results risperidone typical antipsychotics decreased positive negative syndrome scale scores total psychopathology positive negative symptoms baseline ipt total scores five factor scores well number categories completed percentage conceptual level responses significantly lower rtg tatg ncg whereas total response errors perseverative errors failure maintain set significantly higher patient groups ncg repeated measures analysis variance revealed significant main effect time period baseline weeks weeks ipt scores wcst performances significant interactions time period group rtg tatg multivariate analysis variance showed significant differences rtg tatg ipt scores weeks significant differences two groups weeks significant differences also found rtg tatg wcst performances weeks conclusion individuals schizophrenia impairments social cognitive executive function might improved risperidone
proposed aglotos formal specification language dedicated express bdi agent plans according features requirements ambient intelligence ami offers rich modular approach express compose elementary plans order execute concurrently show plan built automatically system concurrent processes mental attitudes agent contrast existing approaches plan viewed realization whole set partially ordered intentions aglotos semantics accords possibility updating sub plans fly intention set bdi agent revised authors published elsevier
head motion reduces data quality neuroimaging data three functional magnetic resonance imaging mri experiments demonstrate people make less head movements task resting state conditions experiment observed less head motion memory encoding task resting state condition experiment using publicly shared data ucla consortium neuropsychiatric phenomics lac study found less head motion several active task conditions resting state condition although task conditions also showed comparable motion healthy controls found head motion men women motion increasing age comparing clinical groups found patients clinical diagnosis bipolar disorder schizophrenia move compared healthy controls patients adhd experiments fixed acquisition order across participants could rule first last scan session might particularly prone head motion therefore conducted experiment collected several task resting state fmri runs acquisition order counter balanced results experiment show less head motion several task conditions rest together experiments demonstrate small head motions occur mri even careful instruction remain still fixation foam pillows head motion lower participants engaged cognitive task finding may inform choice functional runs studying difficult scan populations children certain patient populations findings also indicate differences head motion complicate direct comparisons measures functional neuronal networks task resting state fmri potential differences data quality practice task reduce head motion might especially useful acquiring structural mri data weighted diffusion mri research clinical settings
paper presents set experiments formal modelling verification deadlock avoidance algorithm automatic train supervision system ats algorithm modelled verified using four formal environment namely umc promela spin nusmv mcrl experience gained multiple modelling verification experiments described show algorithm design structured set concurrent activities cooperating shared memory replicated formal frameworks taken consideration relative effort addition highlight specific peculiarities various tools languages emerged along experience
individual involvement treatment decisions providers often use decision support aids improves quality care study investigates implementation strategy bring decision support community mental health centers cmhc fifty two cmhcs implemented decision support toolkit supported month learning collaborative using breakthrough series model participation learning collaborative activities high indicating feasibility implementation model progress staff meeting process aims around utilization components toolkit improved significantly time survey responses individuals service corroborate successful implementation community based providers able successfully implement decision support mental health services evidenced improved process outcomes sustained practices year structure learning collaborative model
trigeneration systems widely used owing high efficiency low greenhouse gas emission high reliability especially trigeneration systems taking renewable energy primary input paid attention paper presents feasible trigeneration system realizes bio mass solar energy integrating effective utilization according energy cascade utilization energy level upgrading chemical reaction principle proposed system solar energy mid low temperature converted chemical energy bio gas gasification process bio gas taken fuel internal combustion engine ice generate electricity jacket water byproduct generated ice utilized liquid desiccant unit providing desiccant capacity flue gas transported absorption chiller heat exchanger consequently supplying chilled water domestic hot water thermodynamic performance trigeneration system investigated help aspen plus results indicate overall energy efficiency electrical efficiency proposed system incase study respectively introduction solar energy decreases consumption biomass solar thermal energy input fraction addition primary energy saving ratio annual total cost saving ratio compared separated generation system respectively elsevier ltd rights reserved
women leaders scarce evangelical mission organizations part reason may gender role stereotypes function strongly much evangelicalism article presents stories two women worked executive level leadership positions evangelical mission organizations using narrative analysis critical feminist lens examine stories understand women describe leadership portray use power strength gender role stereotypes evangelical gender roles appeared define limit power able use long stayed within prescribed norms experienced success deviations gender role stereotypes led sanctions organizations conclusions implications stereotypes may limit women leadership women organizations need become aware unspoken assumptions may functioning recommendations women leaders organizations seeking incorporate women leadership offered
presented herein new computational strategy eliminate thermal effect measured responses internal forces structure thermal load components estimated alternately time step based recursive least squares algorithm noise effect measured data estimated force previous steps removed kalman filter approach directly models thermal effects dynamic responses without temperature information approach adopts force identification technique researched extensively last two decades effectiveness proposed approach validated via numerical studies bridge structure without noise measured data thermal load structural components estimated accurately proposed strategy less error noise measured responses structure
experimental analytical study investigates double averaged turbulent flow characteristics within array large gravel obstacles found atop porous gravel bed analysis experimental data reveals streamwise velocity preserves logarithmic law form induced sublayer linear law third degree polynomial function apply within form induced interfacial sublayers respectively form induced shear stress reynolds shear stress rss occurring virtual bed level turbulent kinetic energy tke components streamwise vertical attain peak values obstacle crest level diminish sharply virtual bed level fluxes tke streamwise vertical components however change signs slightly crest level indicating changeover dominance bursting events tke budget tke production diffusion pressure energy diffusion rate terms attain peak values crest level tke dissipation rate peak value virtual bed level third order moments velocity fluctuations follow linear relationship signs change slightly crest level quadrant analysis suggests sweep events governing mechanism near bed flow region ejection events become predominant increase vertical distance quadrant plots form induced velocity components display pseudo elliptical scatter within interfacial sublayer small circular cluster form induced sublayer
success problem solving form innovativeness help animals exploit environments recent research suggests may correlate reproductive success innovativeness proposed especially beneficial urbanized habitats suggested superior problem solving performance urban individuals species stronger selection innovativeness cities natural habitats expect problem solving performance greater positive effect fitness urbanized habitats tested idea great tits parus major breeding two urban sites two forests measuring problem solving performance obstacle removal task food acquisition task urban pairs significantly faster problem solvers tasks solving speed obstacle removal task positively correlated hatching success number fledglings whereas performance food acquisition task correlate reproductive success relationships differ urban forest habitats neophobia sensitivity human disturbance risk taking presence predator explain relationships problem solving performance either habitat type reproductive success results suggest benefit innovativeness terms reproductive success similar urban natural habitats implying problem solving skills may enhanced urban populations benefits increased survival reduced costs opportunities gain practice challenging tasks
recently researchers field structural health monitoring shm rigorously striving replace conventional nde techniques smart material based shm techniques employing smart materials piezoelectric materials instance electromechanical impedance emi technique employing piezo impedance lead zirconate titanate pzt transducer known sensitivity detecting local damage practical applications various external factors fluctuations temperature loading affecting effectiveness emi technique ought understood compensated paper aims investigating damage monitoring capability emi technique presence axial stress fixed boundary condition compensation technique using effective frequency shift efs cross correlation analysis incorporated compensate effect loading boundary stiffening experimental tests conducted inducing damages lab sized aluminium beams presence tensile compressive forces two types damages crack propagation bolts loosening simulated efs compensation cross correlation coefficient index reduction peak frequency found efficient characterizing damages presence varying axial loading
paper presents results simulation electrical circuits microwave oscillators conducted within microwave office design software suite purpose simulation optimization minimize phase noise millimetre wave frequency synthesizer find optimal designs reference oscillators voltage controlled oscillator circuits effects incorporating bipolar field effect transistor circuits phase noise various circuits supplying bias voltage base gate transistor methods incorporating quartz crystals frequency tuning methods voltage controlled oscillator circuits studied low phase noise reference oscillator millimetre wave voltage controlled oscillator circuits presented article
propose two step approach construction planar smooth collision free navigation paths obstacle avoidance techniques rely classical data structures initially considered identification piecewise linear paths intersection obstacles given scenario variations shortest piecewise linear path angle based criteria proposed discussed second part scheme rely spline interpolation algorithms tension parameters provide smooth planar control strategy particular consider class curves pythagorean structures provide exact computation fundamental geometric quantities selection test cases demonstrates quality new motion planning scheme elsevier ltd rights reserved
accumulating evidence suggests ribosomal proteins may extraribosomal functions various physiological pathological processes including cancer analyzed expression cirha ribosomal protein colorectal carcinoma para carcinoma samples bioinformatics analyses data extracted cancer genome atlas colorectal cancer cell lines vitro qpcr cirha highly expressed carcinoma samples colorectal cancer cells also transduced rko colorectal cancer crc cell line lentivirus mediated small interfering rnas sirnas studied impact knockdown cirha expression cell growth rna interference rnai mediated inhibition cirha expression significantly suppressed proliferation increased apoptosis transduced cells tended arrest phase data suggest cirha plays critical role proliferation cell cycle distribution apoptosis human malignant colorectal cells might therefore potential target therapeutic strategies
subjects patients angioimmunoblastic cell lymphoma aitl underwent fluoro deoxy glucose fdg positron emission tomography computed tomography pet baseline interim cycles predictors progression free survival pfs overall survival assessed positive interim pet deauville score significant independent predictor poor pfs hazard ratio showed marginal significance predict less decrease average change maximum standardized uptake value normalized lean body mass sulmax also significant independent predictor poor pfs hazard ratio poor hazard ratio interim pet significant prognostic value predicting pfs patients aitl deauville score percent decrease sulmax potential useful parameter classifying patients good poor responders
unusual case recurrent myositis ossificans bilaterally hamstring muscles year old athlete secondary trauma presented review literature current treatment options common condition occurs among athletes association muscle tendon strain contusion extensive literature review believe first case reported recurrent bilateral nonsurgical setting recurrent hamstring strains plain radiographs physical examination revealed appearance chronology pathology treatment options improve flexibility decrease morbidity discussed along prophylaxis future injury treatment mobility flexibility rehabilitation goals treatment nonsteroidal anti inflammatory drugs bisphosphonates magnesium discussed along prophylaxis
latency jitter pressing problem virtual reality applications paper analyzes latency jitter caused typical interprocess communication ipc techniques commonly found today computer systems used test programs measure seal ability latencies various ipc techniques increasing number threads performing task concurrently use four different implementations vanilla linux kernel well real time linux kernel assess variant multiuser multiprocess operating system prevent latency spikes behavior would apply different programming languages ipc techniques found linux limit latency jitter cost throughput certain implementations coarse grained concurrency employed avoid adding scheduler latencies especially native system space ipc actor systems found support higher degree concurrency granularity higher level abstraction
work novel four terminal perovskite sic based rear contact silicon tandem solar cell device proposed simulated achieve power conversion efficiency pce single illumination efficient semitransparent perovskite top subcell used perovskite silicon tandem architecture tandem structure perovskite silicon solar cells promising method achieve efficient solar energy conversion low cost four terminal tandem configuration cells connected independently hence avoids need current matching top bottom subcell thus giving greater design flexibility simulation analysis shows pce thick rear contact bottom subcell respectively substantial improvement comparing transparent perovskite solar cell solar cell operated individually impact perovskite layer thickness monomolecular bimolecular trimolecular recombination also obtained performance perovskite top subcell reported pces times times higher compared experimentally available efficiencies thick stand alone silicon solar cell devices respectively presence sic significantly suppressed interface recombination bottom silicon subcell detailed realistic technology computer aided design tcad analysis performed predict behaviour device elsevier ltd rights reserved
human dog interaction relies large extent nonverbal communication therefore plausible human sensitivity nonverbal signals affects interactions human dog experience dogs also likely influence human dog interactions suggested influences human social skills present study investigated possible links human nonverbal sensitivity experience dogs quality human dog interactions two studies reported study veterinary students took psychometric test assessing human nonverbal sensitivity answered questionnaire experience dogs data obtained used investigate relationship experience dogs sensitivity human nonverbal communication results indicate experience dogs improves human nonverbal sensitivity study students high students low levels human nonverbal sensitivity selected students interacted unknown dog greeting situation human dog interactions videoed found combined score dog behaviors relating insecurity associated students level nonverbal sensitivity experience dogs dog showed insecure behavior interacting students low level nonverbal sensitivity experience dogs interacting students high level nonverbal sensitivity irrespective experience dogs
much research bitemporal databases focused modeling time related data either attribute tuple timestamping attribute timestamping approach attaches bitemporal data attributes tuple timestamping approach splits object history several tuples although numerous studies bitemporal data models work contrasting two common approaches terms system performance ease use paper compared interval based attribute tuple timestamped bitemporal data models running sample queries measure processing time evaluated usability using data tests indicate attribute timestamping model one level nested approach required less time used less disk space therefore appropriate modeling bitemporal data
background posterior cruciate ligament pcl reconstructions rarely performed compared anterior cruciate ligament acl purpose evaluate clinical functional outcome isolated multiligament pcl reconstruction study design cohort study level evidence methods patients underwent pcl reconstruction included standardized follow performed consisted subjective scores tegner activity score knee injury osteoarthritis outcome score koos subjective international knee documentation committee ikdc score objective measures including knee laxity extension strength overall ikdc score results one hundred ninety six patients identified available postoperative follow isolated pcl multiligament injury one hundred ten patients available complete clinical follow subjective questionnaires patients returned subjective questionnaires mean follow years range years koos scores follow isolated pcl group subscale symptoms pain activities daily living sport quality life scores patients multiligament group symptoms pain activities daily living sport quality life tegner scores respectively subjective ikdc scores mean side side difference knee laxity isolated pcl group compared multiligament group year follow significant differences koos outcome scores isolated pcl subgroup multiligament subgroup differences final follow twelve patients pcl revision surgery within follow period conclusion despite type injury minor differences knee laxity subjective outcome scores isolated pcl group multiligament group overall revision rate study
water management important issue urban design due growing concern water scarcity result rainwater harvesting system received notable attention alternative water source rainwater one purest form waters easily accessed via rainwater harvesting system general performance rainwater harvesting system estimated based historical rainfall data without possible impacts climate change rainfall however rainfall pattern likely change future consequence climate change may affect performance rainwater harvesting system research climate change impacts rainwater harvesting limited objective study understand plausible impacts climate change performances water savings reliability water security residential rainwater harvesting system based projected future rainfall conditions continuous daily simulation water balance model developed based behavioural analysis yield spillage criteria simulate performances rainwater harvesting system analysis conducted five locations greater sydney region australia results indicate performances rainwater harvesting system impacted negatively due climate change conditions future found given tank size selected locations would able supply expected volume water changing climate conditions future water savings going reduced rainwater harvesting system future reduction tank indoor water demand moreover number days year meet water demand rainwater harvesting system reliability likely reduced reduction tank indoor water demand also percentage days rainwater tank would remain completely empty likely increase future future climate conditions comparison historical conditions indoor water demand furthermore found performance rainwater harvesting system affected dry season wet season findings study help water authorities policy makers well home owners improve understanding climate change impact residential rainwater harvesting system assist selecting appropriate rainwater tank size context climate change elsevier ltd rights reserved
paper reports new foundation system self regulating membrane foundation embankments deep soft soil deposits stockpiles infrastructure embankments load bearing behavior system analyzed means centrifuge model tests comprehensive numerical simulations global sensitivity analyses parametric studies results analyses derived design approach presented paper paper concludes validation design approach comparison results numerical simulation
systematic review allows identify assess interpret possible relevant work associated question particular subject area different authors use several methodologies learn research related research different fields main objective review identify work research publications made field mobile monitoring patients application commercial non commercial solutions health next compare different solutions solution momo mobile monitoring framework momo solution allows patient mobile monitoring mobile phones biometric devices blood pressure meter glucometer others systematic review based methodology kitchenham proposed specific guidelines carrying systematic review software engineering prepare systematic review base selection primary secondary research related mobile monitoring solutions following criteria specific weight compare part research
introduction end marked media alerts regarding combined hormonal contraceptives chc lawsuit pharmaceutical companies selling birth control pills study analyzed whether information impact number abortion methods prospective study determining number women asking abortion spontaneously declare contraception defect due abandon oral contraception scared information received media medication results eleven centers participate study allowing study abortion time frame ninety eight pregnancies due interruption contraceptive treatment consequence media alerts average age years old within pregnancies started december months beginning alerts january february march months later cases chc stopped fear information reported media generation cases generation cases generation microprogestative cases conclusion women declared stopped birth control medication fear information reported media represented number abortions performed february april elsevier masson sas rights reserved
opioid receptor selective antagonists highly desirable utility pharmacological probes receptor characterization functional studies furthermore opioid receptors act important target drug abuse addiction treatment previously reported nap novel lead compound high selectivity affinity towards opioid receptor based nap synthesized derivatives characterized binding affinities selectivity towards receptor nmp ngp identified two selective mor ligands among nap derivatives present study molecular modeling methods applied assess dual binding modes nap derivatives particularly nmp ngp three opioid receptors order analyze effects structural modifications pyridyl ring nap binding affinity selectivity results indicated steric hindrance electrostatic hydrophobic effects caused substituents pyridyl ring nap contributed complimentarily binding affinity selectivity nap derivatives three opioid receptors analyses contributions provided insights future design potent selective opioid receptor ligands published elsevier ltd
recently use sustainable forms transportation electric vehicles evs delivering goods parcels customers urban areas received attention urban planners private stakeholders provide insights toward use evs work develops optimization framework using portfolio theory takes account cost risks associated input parameter uncertainties determining optimal combination evs internal combustion engine vehicles icevs urban freight transportation uft planning time period model assist urban freight operator choose best investment strategy introducing new vehicles fleet gaining economic benefits positive impacts urban environment taking account risks involved numerical results show evs potential compete icevs uft elsevier ltd rights reserved
introduce new approach principled design evolutionary algorithms eas based kernel methods demonstrate kernel functions capture useful problem domain knowledge used directly construct search operators test two kernel search operators suite four challenging combinatorial optimization problem domains novel kernel search operators exhibit superior performance traditional search operators
indexing table developed angle measurements machine tools measuring techniques reviewed paper currently available manufacturing engineering calibrate angle measurement measuring principles equipment outlined capabilities also discussed new indexing table using points kinematic concept employing ball vee grooves location designed manufactured calibrate angle errors rotary tables using laser interferometer manufacturing method evaluated manufacture accurate vee grooves special cam designed manufactured translate rotation movement lift rotation movement cnc machining centre indexing head used manufacture cam parts new indexing table manufactured manufacturing tolerance according drawings squareness parallelism checked obey points kinematic concept also factors controlled repeatability new indexing table installing new indexing table performance evaluated using rotary table operating horizontal vertical orientations
power system reliability faces serious challenges supply shortage occurs unexpected generation transmission line outages especially extreme weather conditions alternative conventional approaches solicit aids generation side operators leverage demand side resources variety electricity market mechanisms balance active power enhance system reliability benefits demand response long recognized many works empirical cases systematic analyses however never addressed assess values market based supporting system reliability paper case study performance pjm interconnections north american polar vortex provided highlight significant contributions improving system reliability maintaining grid stability programs unique merits technical economic environmental aspects exhibited extreme event verse conventional system reliability improving approaches also demonstrated accordingly furthermore reveal difference programs driven various existing market mechanisms describing fundamental functions values various programs also highlighted last challenges opportunities facing china design implementation programs transform monopoly scheme open electricity market power industry restructuring recent years also discussed elsevier ltd rights reserved
time cost quality tcq triple constraint construction projects dependent conflicting objectives considering limited resources estimation approximate tcq complex dynamic problem addition uncertain nature construction projects highly variable alternatives make decision making process complicated issue order overcome difficulties many researchers related academic literature introduced different mathematical models tcq trade problem far models two different approaches used estimate tcq related data continues approach assumed relationship among three components could expressed continuous functions discrete approach accepted construction method crew formation iii crew overtime policy impacts project tcq relationships among three components become discrete however previous studies construction materials significant impact tcq construction activities projects taken account completely data formation process exception rayes kandil considered different strengths concrete material alternatives highway construction project fact studies focused proving applicability different optimization techniques instead optimizing tcq real construction project context simple projects including limited number activities used evaluate applicability developed models therefore present study aimed outline new two step methodology including alternative construction material utilization tcq trade problems especially building projects enable utilization high variety construction materials purpose impact construction materials tcq project explained detailed manner authors published elsevier ltd
late onset hypogonadism defined combination low testosterone levels typical symptoms signs major area uncertainty whether concentrations always really sufficient fully reflect leydig cell dys function mild testicular alteration could diagnosed additional biochemical markers luteinizing hormone hydroxyvitamin levels markers help identifying called subclinical hypogonadism normal high levels patients hypogonadism frequently low levels hydroxyvitamin due impairment hydroxylating enzyme cypr testis however data published dealing best treatment option cholecalciferol vitamin precursor calcidiol hydroxylated form vitamin patients studied patients classic hypogonadism total subclinical hypogonadism nmol low hydroxyvitamin nmol subjects received cholecalciferol per week calcidiol per week hydroxyvitamin parathyroid hormone pth evaluated months therapy supplementation calcidiol significantly increased hydroxyvitamin significantly decreased pth levels groups men hypogonadism primary subclinical whereas supplementation cholecalciferol modify levels study shows first time administration hydroxylated form vitamin calcidiol administration precursor cholecalciferol restores hydroxyvitamin levels subjects hypogonadism
prolonged neutropenia generally thought major factor invasive pulmonary aspergillosis ipa present study characterize frequency severity duration neutropenia immediately precedes ipa prolonged neutropenia identified one third ipa cases occurred exclusively hematologic patients
leaf area important plant canopy structure parameter important ecological significance light detection ranging technology lidar application terrestrial laser scanner tls appealing method accurately estimating leaf area however actual utility scanner depends largely efficacy point cloud data pcd analysis paper present novel method quantifying total leaf area within tree canopy pcd firstly shape normal vector distribution structure tensor pcd features combined semi supervised support vector machine svm method separate various tree organs branches leaves addition moving least squares mls method adopted remove ghost points caused shaking leaves wind scanning process secondly target tree scanned using two patterns one scan three scans around canopy reduce occlusion effect specific layer subdivision strategies according acquisition ranges scanners designed separate canopy several layers thirdly pcd randomly chosen analytic dataset ads ads innovative triangulation algorithm assembly threshold designed transform discrete scanning points leaf surfaces estimate fractions foliage surface covered laser pulses novel ratio point number leaf area layer defined combined total number scanned points retrieve total area leaves canopy quantified total leaf area tree validated using laborious measurements lai plant canopy analyser portable area meter results showed individual tree leaf area accurately reproduced using method three registered scans relative deviation less nevertheless estimations one scan resulted deviation retrieved individual tree leaf area due occlusion effect indeed study provides novel connection leaf area estimates scanning sensor configuration supplies interesting method estimating leaf area based pcd
silver nanoparticles agnp strong broad spectrum antimicrobial activity gained increased attention development agnp based products including medical food applications initially efficacy agnp silver nitrate agno evaluated inactivating norovirus surrogates feline calicivirus fcv murine norovirus mnv norovirus surrogates exposed agno agnp solutions degrees analyzed cell culture assays agnp silver ions significantly decreased fcv mnv infectivity dose dependent manner concentrations furthermore poly hydroxybutyrate hydroxyvalerate phbv films prepared depositing coating thermally post processed electrospun phbv agnp fiber mats compression moulded phbv films exposure degrees infectious fcv recovered contact agnp films mnv titers decreased log morphology phbv phbv agnp fibers studied sem showed smooth continuous fibers cases edax analysis confirmed homogeneously distribution agnp coating onto phbv phbv layer study showed first time suitability phbv agnp electrospun coating antiviral surfaces elsevier ltd rights reserved
explored linoleic acid alpha linolenic acid ala efficiently converted arachidonic acid docosahexaenoic acid dha adolescent girls aged years mozambique consuming habitually low fat diet low iron zinc status predicts conversion total fat ala intakes energy respectively three areas iron zinc intake varied day day significant negative association plasma found plasma ala significant positive association serum ferritin plasma dha associated negatively plasma ala showed population low intakes ala proportions phospholipid ala determines relative proportions dha low iron status probably attenuates conversion
purpose study investigate whether use computer graphics software would affect elementary school children cognition purpose study carried children painting task observations retrospective interviews focus group conducted view points interpreting influences drawing graphics software may children cognitive development main findings study children accuracy handing intuitive using mouse caused children difficulties drawing tested children choose one color corresponding lcolors showing children single color judgment object children color learning model meet needs color cognitive development stage color replaced reset color using single object corresponding color mobile drawing tools able encourage children contact observation real objects
present paper new generic approach variable branching branch bound mixed integer linear problems approach consists imitating decisions taken good branching strategy namely strong branching fast approximation approximated function created machine learning technique set observed branching decisions taken strong branching philosophy approach similar reliability branching however approach catch complex aspects observed previous branchings take branching decision experiments performed randomly generated miplib problems show promising results
psychopathy personality disorder characterized callous lack empathy impulsive antisocial behavior criminal recidivism performed largest diffusion tensor imaging dti study incarcerated criminal offenders date determine whether psychopathy severity linked microstructural integrity major white matter tracts brain consistent results previous studies smaller samples found psychopathy associated reduced fractional anisotropy right uncinate fasciculus major white matter tract connecting ventral frontal anterior temporal cortices found association left adjacent frontal temporal white matter tracts moreover right finding specifically related interpersonal features psychopathy glib superficial charm grandiose sense self worth pathological lying manipulativeness rather affective antisocial lifestyle features results indicate neural marker key dimension psychopathic symptomatology wiley periodicals inc
achieving false belief understanding important cognitive milestone allows children understand thoughts reality differ researchers found low income children score significantly lower middle income children false belief understanding examined difference exists hypothesized children language parent discipline mediate income false belief relation participants year olds false belief understanding significantly correlated family income children vocabulary parents self reported discussion children behavior discussion emotions power assertion family income significant indirect effect false belief understanding children vocabulary parent discipline examined independently children vocabulary using parallel multiple mediation study contributes knowledge individual differences false belief understanding elsevier inc rights reserved
portable sensors biomedical devices influenced recent advances microfluidics technologies compact fabrication techniques improved detection limits enhanced analysis capabilities paper reports development integrated ultraportable low cost modular digital microfluidic dmf system successful integration smartphone used high level controller post processing station low power cost effective electronic circuits designed generate high voltages required dmf operations open closed configurations smartphone turn commands microcontroller manipulate voltage signals required droplet actuation dmf chip communicates wirelessly microcontroller via bluetooth module moreover smartphone acts detection image analysis station attached microscopic lens holder assembly fabricated using three dimensional printing technology facilitate rapid prototyping holder features modular design enables convenient attachment detachment variety dmf chips electrical busbar electrical circuits controller communication system designed minimize power consumption order run device small lithium ion batteries successful controlled dmf operations basic colorimetric assay using smartphone demonstrated
anxiety stress everyday issues many people high functioning autism cognitive behavioural therapy treatment choice management anxiety challenges using people high functioning autism study used modified experience sampling techniques examine everyday anxiety stress adults high functioning autism explore feasibility delivering real time stress management techniques using mobile platform high levels anxiety found characterised worry confusing thoughts alone associated internal focus imagery rumination participants reported improved mood less worry anxious thinking active phase study results support previous studies indicating people high functioning autism differ experience anxiety provided preliminary data feasibility real time stress management limitations approach discussed together considerations future work area developing clinical interventions mobile platforms
aim paper summarise knowledge anatomy embryology anthropology mandible mandibular foramen also highlight important clinical implications current studies regarding anaesthesia performed region mandible electronic journal search undertaken identify relevant studies published english search included medline embase databases years subject search used combination controlled vocabulary free text based search strategy medline using key words mandible mandibular foramen anatomy embryology anthropology mental reference lists relevant studies existing reviews screened additional relevant publications basing relevant manuscripts short review anatomy embryology anthropology mandible mandibular foramen written
high resolution simulation supertyphoon rammasun performed using advanced research weather research forecasting model model covers initial spin rapid intensification period northern south china sea period weakening landfall results show model reproduces track intensity structure storm environmental circulations reasonably well analysis surface energetics storm indicates storm intensification closely related net energy gain rate epsilon defined difference energy production due surface entropy flux energy dissipation due surface friction near radius maximum wind rmw stage epsilon high indicating sufficient energy supply storm intensify however epsilon decreases rapidly storm quickly intensifies increases rapidly near rmw time storm reaches peak intensity larger near rmw leading local energetics deficit eyewall mature stage reach balance within radius storm center times rmw implies local eyewall large enough balance radially inward energy transport outside eyewall must play important role maintaining storm intensity well intensification
paper concerned cooperative target pursuit problem multiple agents based directed acyclic graph target appears random location moves sensed agents agents pursue target detect existence since ability agent may different consider heterogeneous multi agent systems according topology multi agent systems novel consensus based control law proposed target agents modeled leader followers respectively based mason rule signal flow graph analysis convergence conditions provided show agents catch target finite time finally simulation studies provided verify effectiveness proposed approach
public health burden posed borderline personality disorder bpd rivals associated major mental illnesses prevailing disposition psychiatrists toward disorder remains characterized misinformation stigma aversive attitudes insufficient familiarity effective generalist treatments delivered nonspecialized health care settings residency training programs well positioned better equip next generation psychiatrists address issues consensus guidelines currently exist residents taught managing bpd instead disproportionately limited curricular time teaching non evidence based approaches modeling conceptually confused combinations techniques drawn specialty bpd treatments offered article explain training generalist model sensible alternative approaches appropriate residents propose plan giving residents adequate training via generalist model highlighting minimal didactic clinical training objectives dubbed core competencies milestones model curriculum developed massachusetts general hospital mclean hospital residency program describe obstacles implementation effective generalist training posed infrastructural faculty centered resident centered variables
many difficult problems applied mathematics scientific disciplines solved without powerful computational systems symbolic computation computer graphics paper construct two new families fourth order iterative methods finding multiple real complex zero given function developing methods recurrent formula generating iterative methods higher order solving nonlinear equations applied implemented symbolic computation several programs computer algebra system mathematica symbolic computation tool solving considered complex problem since provides handling manipulating complex mathematical expressions mathematical objects properties proposed rapidly convergent methods illustrated several numerical examples examine convergence behavior presented methods also give dynamic study methods using basins attraction methodology besides visualization iterative processes deliveries important features iterations including running cpu time average number iterations function starting points program plotting basins attraction mathematica included elsevier inc rights reserved
maximum distance separable mds matrices employed create diffusion layers block ciphers hash functions mds matrices generated linear codes reduce cost software hardware implementations however linear codes generate limited number mds matrices finite field consequence many block ciphers adopt matrices paper describes design generator create large number different mds matrices time changing parameters high dimensional cat map named multi mds matrix generator identify three types cat matrices used construct multi mds matrix generator addition prove proposed mds matrices small number different elements xor gates efficient terms implementation performance finally show multi mds matrix generator inherits dynamical properties high dimensional cat map improving resistance diffusion layers powerful techniques cryptanalysis elsevier gmbh rights reserved
functional index hand osteoarthritis fihoa commonly used patient reported outcome questionnaire designed measure function patients hand osteoarthritis objective study evaluate validity reliability persian version fihoa persian translated version fihoa administered native persian speaking patients iran hand osteoarthritis thirty six patients completed questionnaire two occasions week apart physical component numerical rating scale used evaluate construct validity persian version fihoa internal consistency high cronbach alpha test retest reliability total score excellent weighted kappa significant positive correlation total fihoa score numerical rating scale significant negative correlation total fihoa score physical component scale observed persian version fihoa showed adequate validity reliability evaluate functional disability persian speaking patients hand osteoarthritis
paper explores important characteristics system linear equations containing parameters system equations arises many branches engineering including electrical circuits hydraulic networks truss structures parametrized solution set linear equations obtained applying cramer rule many practically important cases parameters appear rank one dependency resulting parametrized solutions rational multilinear form monotonic parameter monotonic characteristic practical importance analysis design linear systems parameters interval uncertainties particular extremal values system variables occur vertices parameter boxes
paper examined recognition facial expressions emotion normal population inmates mild offenses inmates severe offenses antisocial personality disorder apd participants shown images faces expressing emotions asked identify types emotions expressed predicted inmates would difficulties process recognition emotions especially inmates apd compared accuracy interpretation inmates accuracy normal population also types inmates results confirmed assumptions results consistent vast majority research topic believe aspects related emotional intelligence involved process recognition emotions transmitted facial expressions
background depression common symptom stroke neural substrates remain unclear ascending serotonergic system originates raphe nuclei brainstem hypothesized depressive disorder due brainstem infarction associated damage raphe nuclei methods prospectively enrolled patients first ever acute isolated brainstem infarction observational cross sectional study patients evaluated using montgomery ksberg depression rating scale madrs clinician rated version apathy evaluation scale aes mini mental state examination mmse depressive disorder diagnosed according dsm madrs score greater diffusion tensor imaging proton density weighted images used identify damage raphe nuclei accordingly patients classified either raphe nuclei damaged intact group prevalence depressive disorder madrs aes mmse scores compared two groups results depressive disorder frequent damaged group intact group madrs scores higher damaged group intact group mean whereas aes mmse scores differ groups limitations assess damage ascending projection fibers raphe nuclei conclusions results suggest damage raphe nuclei underlies depressive disorder due brainstem infarction possibly via serotonergic denervation
although certain drugs abuse known disrupt brain glucose metabolism bglum effects opiates bglum well characterized moreover preclinical positron emission tomography pet studies anesthetize animals scan limits clinical applications investigated effects isoflurane anesthesia intravenous morphine self administration msa bglum rats jugular vein cannulated adult male sprague dawley rats self administered either saline ssa morphine infusion day days animals scanned twice fluoro deoxyglucose fdg pet baseline day withdrawal self administration injection fdg one batch animals anesthetized isoflurane batch kept awake fdg uptake min fdg uptake animals anesthetized order perform pet scan min isoflurane anesthesia compared awake condition reduced bglum olfactory cortex thalamus basal ganglia increasing bglum midbrain hypothalamus hippocampus cerebellum morphine self administered animals exhibited withdrawal signs piloerection increased defecation drug seeking locomotor stimulation morphine day withdrawal bglum striatum increased msa group compared ssa group effect observed isoflurane anesthesia awake condition findings suggest choice fdg uptake condition may important preclinical pet studies increased bglum striatum may associated opiate seeking withdrawal
several factors related immune system history allergies virus infections may associated acute lymphoblastic leukemia purpose study analyze whether presence atopic diseases previous infection parvovirus epstein barr virus ebv associated development case control study performed two tertiary hospitals located northeastern brazil study population included patients diagnosed non cell using myelogram immunophenotyping patients control group atopy evaluated via parent questionnaire medical records total immunoglobulin igg levels parvovirus ebv measured serum logistic regression performed assess association variables odds identified significant inverse association rhinitis urticaria elevated ige serum levels history parvovirus infection showed significant association type cancer logistic regression presence atopy protective factor presence igg parvovirus important risk factor results suggest atopic diseases elevated total ige levels associated potential protective effect development previous infection parvovirus contributed susceptibility
paper describes conditions simple circuit modifications eliminate undesired complex conjugate poles two stage operational amplifiers based current buffer miller compensation complex conjugate poles main problem frequency compensation topology since first introduction years ago shown resistor added second stage amplifier output creates zero improves stability reduces circuit second order system greatly simplifies design otherwise complex topology time retains valued benefits current buffer based frequency compensation addition case short channel transistor used current buffer conditions create sufficient phase margin inner loop amplifier without nulling resistor formulated
american society nephrology annual kidney week meeting recognized world premier nephrology event kidney health professionals world gathered edition latest scientific research developments renal disease field presented san diego convention center aiming engage discussion exchange knowledge kidney experts scientific exposition plenary educational poster sessions industry sponsored educational symposia
fast technique full wave optimization transmission reflection properties general linear time invariant high frequency components proposed method based zeros poles rational function representing scattering parameters device designed generalization technique developed design optimization microwave filters performance proposed technique demonstrated two examples patch antenna branchline coupler fast convergence observed examples regardless quality starting point
surface passivation essential step atomistic simulations many possible surface passivation results given device model semiconductor devices consist gaas materials bonding directions surface atoms may unique based structure analysis given model generation method structure descriptor sdg proposed surface passivation compared existing solutions sdg method provides trimmer results also reduces torsion angle energy model preferred simulation atomistic models efficiency method validated test results several applications
neoliberal direction social policy new zealand fifth national government demonstrated white paper vulnerable children document advocates increased monitoring policing welfare populations downgrading child protection policy technical administrative system managing risky families white paper release came soon coroner report deaths kahui twins treated media shocking case child abuse exemplified media use fantasy savage maori welfare underclass reporting cases child abuse drawing isin analysis governing neurosis article explores media policy discourses reinforce normative patterns neoliberal citizen subjectivity offering compelling pathways anxiety route citizens anxiety child abuse support neoliberal modes citizen subjectivity
recent research western populations demonstrated children use imitation flexibly engage instrumental conventional learning evidence children imitative flexibility non western populations limited however assessed imitation instrumental tasks study year olds demonstrates cultural continuity cultural variation imitative flexibility children engage higher imitative fidelity conventional tasks instrumental tasks industrialized western culture united states subsistence based non western culture vanuatu children vanuatu engage higher imitative fidelity instrumental tasks united states potential consequence cultural variation child socialization conformity
purpose study evaluate procedure generate derived categorical responding three children disabilities promote emergence untrained intraverbal categorical responses study three member equivalence classes including three stimuli category name class trained using match sample procedure test probes conducted categorical responding including trained two derived relational responses well emergence untrained intraverbal categorical responding throughout study relational training effective promoting emergence categorical responding two three participants demonstrated emergence additional intraverbal responding without prior training results provide evidence supporting practical utility stimulus equivalence well peak curriculum
autobiographical implicit association test alat sartori variant implicit association test iat greenwald used establish whether autobiographical memory encoded respondent mind brain specifically alat possible evaluate one two autobiographical events true method consists computerized categorization task alat includes stimuli belonging four categories two logical categories represented sentences always true front computer always false climbing mountain respondent two categories represented alternative versions autobiographical event went paris christmas went new york christmas one true true autobiographical event identified combined block gives rise faster reaction times shares motor response true sentences reviewed validation experiments found accuracy detecting true memory show agreement identifying true autobiographical memory alat repeated twice average report technique estimating accuracy associated single classification based iat value may used single subject investigations show alat might used identify also true intentions reasons conclude series guidelines building effective iat
article describes practical lectures innovated experience practical case study design implementation geographical information system botangis brought several innovations study branch geoinformatics faculty science palacky university olomouc article deals mainly introducing new practical example course database systems new theme explains design inner structure relational database botangis valuable contribution lies way real database example practice explained students process education instruction started visit botanical garden collection greenhouses subsequently students worked computer laboratory trying find information plants various queries botanical portal botangis finally detailed model relational database explained teacher experience enriched students knowledge field conceptual database design
study aims determine whether possible modify executive function stressed individuals means cognitive behavioral therapy stress management thirty one people high levels perceived stress recruited study treatment group wait list group treatment group received weeks stress management program psychological executive function variables evaluated groups pre post intervention treatment group showed improved psychological variables perceived stress vulnerability stress superstitious thinking likewise results showed statistically significant differences personality variables related executive function positive urgency sensitivity reward improved therapy variables showed moderate high effect size oscillates perceived stress sensitivity reward cognitive behavioral therapy stress management may appropriate strategy improving personality construct components related executive function however effects therapy showed performance tests executive function applied presented studies previous
aripiprazole atypical antipsychotic drug approved worldwide treatment acute long term schizophrenia adults increasingly atypical antipsychotics playing key role management schizophrenia aim present study design mucoadhesive dosage form buccal delivery aripiprazole could provide rapid drug delivery systemic circulation nanocrystals aripiprazole prepared nano precipitation using acid base neutralization nanocrystals incorporated buccoadhesive chitosan films drug loaded films found smooth non tacky possessing high mechanical strength films characterized crystallinity drug surface thickness folding endurance swelling behavior mucoadhesive strength drug release vivo permeation across rabbit cheek mucosa vitro drug release studies indicated distinctly higher drug release nanocrystal loaded films fapz fapz permeation studies indicated higher flux films fapz compared film fapz promising results indicate developed nanocrystal loaded buccal films fapz potential provide faster availability aripiprazole buccoadhesive films offer promising option patients schizophrenia especially geriatric patients
chaos power electronic systems electric motor drives introduced decades ago follow numerous research literature however chaos permanent magnet synchronous motors particular seems receive enough deserved interest considering fact paper designs linear quadratic regulator lqr suppress chaotic behaviors pmsms stability robustness properties proposed lqr fully presented noted first time robustness lqr chaos suppression pmsms discussed due robustness properties proposed lqr scheme eliminate chaos also provide better performances conventional methods simulations results various scenarios prove superiority proposed control technique conventional controllers
due compl growth large scale integration circuits task optimal analog integrated circuit design hand difficult optimization time consuming process many conflicting criteria wide range design parameters characterization complex tradeoffs nonlinear objectives assuring required specifications makes analog circuit design tedious process design optimization processes automated high accuracy evolutionary technique may proficient implement automatic design analog integrated circuits one challenging topics vlsi design process paper presents competent approach optimal designs two analog circuits namely complementary metal oxide semiconductor two stage comparator type metal oxide semiconductor input driver channel input folded cascode operational amplifier evolutionary technique used particle swarm optimization pso aging leader challenger alc pso main aim optimize mos transistors sizes using alc pso order reduce areas occupied circuits get better performance parameters circuits exhibit performance parameters circuits simulation program integrated circuit emphasis simulation carried using optimal values mos transistor sizes design parameters simulation results demonstrate design specifications closely met required functionalities accommodated simulation results also show alc pso superior algorithms terms mos area performance parameters like gain power dissipation etc examples considered
objective aim studywas identify clinical demographic characteristics moderate response treatment fesoterodine among women diagnosis urgency predominant urinary incontinence methods multicenter double blinded week randomized controlled trial pharmacologic therapy urgency predominant urinary incontinence community dwelling women diagnosed item incontinence questionnaire previously performed participants randomized fesoterodine therapy daily placebo urinary incontinence assessed day voiding diaries secondary analysis responder defined reduction greater overall incontinence episode frequency compared baseline clinical demographic characteristics may moderate treatment response assessed testing interaction characteristics intervention logit models responders adjusting clinical site results participants ages mean years white race mean urgency incontinence episodes per day baseline differences demographic clinical incontinence characteristics treatment placebo groups responders nonresponders increase proportion responders fesoterodine increasing age parity among married women effect modification observed race ethnicity body mass index education employment status alcohol tobacco use conclusions ambulatory women urgency predominant urinary incontinence older age married higher parity significantly moderated potentiated effects pharmacologic therapy incontinence frequency study identifies certain populations may increased responsiveness treatment antimuscarinic therapy andmay used inform guide future therapy
objectives study aimed evaluating biological response titanium implants coated irradiated dehydrocholesterol dhc vitamin vite invivo analyzing effects aging stability bioactivity invitro material methods titanium surfaces coated dhc vite irradiated incubated degrees allow cholecalciferol synthesis invivo biological response tested using rabbit tibia model weeks healing analyzing wound fluid mrna levels several markers bone implant interface stability coating storage weeks determined using hplc analysis bioactivity stored modified implants studied invitro study mct cells results significant increase gene expression levels osteocalcin found bone tissue attached implants coated low dose dhc vite together higher alp activity wound fluid implants treated high dose dhc vite showed increased tissue necrosis inflammation regarding aging effects coated implants stable bioactive weeks stored degrees avoiding oxygen light moisture conclusion study demonstrates implants coated irradiated dhc vite promote invivo gene expression bone formation markers alp activity keep osteopromotive potential invitro composition stored weeks degrees
construction industry crucial component hong kong economy safety efficiency workers two main concerns current approach training workers relies primarily instilling practice experience conventional teacher apprentice settings site limitations however site training inefficient interferes progress site site training provides little opportunity develop practical skills awareness needed hands experience effective way train workers safety awareness efficient working current novel information technologies paper describes new innovative prototype system proactive construction management system pcms train precast installation workers highly productive fully aware hazards involved pcms uses chirp spread spectrum based css real time location technology unityd based data visualisation technology track construction resources people equipment materials etc provide real time feedback post event visualisation analysis training environment trial precast facade installation real site demonstrates benefits gained pcms comparison equivalent training using conventional methods concluded although study based specific industrial conditions found hong kong construction projects pcms may well attract wider interest use future elsevier rights reserved
present study graphene oxide used adsorption anionic azo dyes acid orange direct red aqueous solutions characterized fourier transform infrared spectroscopy ftir ray photoelectron spectroscopy xps thermogravimetric analysis tga atomic force microscopy afm ray diffraction xrd scanning electron microscopy sem high resolution transmission electron microscopy hrtem zeta potential measurements influence dye initial concentration temperature adsorption onto investigated equilibrium data analyzed model equations langmuir freundlich temkin dubinin radushkevich redlich peterson isotherms best represented langmuir redlich peterson isotherm model kinetic adsorption data analyzed using pseudo first order kinetic model pseudo second order kinetic model intraparticie diffusion model adsorption kinetics well fitted using pseudo second order kinetic model thermodynamics parameters delta degrees delta degrees delta degrees calculated indicating adsorption onto spontaneous process adsorption process onto exothermic adsorption onto endothermic nature elsevier inc rights reserved
purpose present review provide overview current understanding epidemiology etiology risk factors prevention methods anterior cruciate ligament acl injury alpine ski racing provide overview known pertaining acl reinjury return sport acl injury alpine ski racing given scientific studies acl injuries alpine ski racing descriptive studies contributed higher level scientific evidence nonsystematic narrative review employed three scholarly databases searched articles acl injury knee injury alpine ski racing studies classified according relevance relation epidemiology etiology risk factors return sport reinjury prevention alpine ski racers skiers found high risk knee injuries acl tears frequent diagnosis three primary acl injury mechanism identified involved tibial internal rotation anteriorly directed shear forces ski equipment environment trunk muscle strength imbalance genetics found predictive acl injuries development level skiers limited scientific data acl injury risk factors among elite skiers based expert opinion research injury risk factors focus equipment design course settings speed athlete factors fitness skiers seem make successful recovery following acl injury may persistent neuromuscular deficits future research efforts directed toward prospective studies acl injury reinjury prevention male female skiers toward effects knee injury long term health outcomes early development osteoarthritis international collaborations may necessary generate sufficient statistical power acl injury reinjury prevention research alpine ski racing
trpm bifunctional protein comprising trp cation channel segment covalently linked alpha type serine threonine protein kinase trpm expressed intestinal renal epithelial cells loss function mutations human trpm gene give rise hypomagnesemia secondary hypocalcemia hsh suggesting trpm channel kinase plays central role systemic homeostasis contrast trpm null mice show delay prenatal development neural tube defects prenatal death possible functions trpm prenatal adult organisms discussed chapter
energy harvesters used power autonomous systems output power variable intermittent sustain computation systems integrate batteries supercapacitors smooth rapid changes harvester output energy storage devices require time charging increase size mass cost systems field transient computing moves away approach powering system directly harvester output prevent application restart computation power outage approaches hibernus allow systems hibernate supply failure imminent supply reaches operating threshold last saved state restored operation continued point interrupted paper proposes hibernus intelligently adapt hibernate restore thresholds response source dynamics system load properties specifically capabilities built system autonomously characterize hardware platform performance hibernation order set hibernation threshold point minimizes wasted energy maximizes computation time similarly system auto calibrates restore threshold depending balance energy supply consumption order maximize computation time hibernus validated theoretically experimentally microcontroller hardware using synthesized real energy harvesters results show hibernus provides average reduction energy consumption improvement application execution time state art approaches
objective determine healthcare resource utilization hcru biologic naive initiators tnf inhibitors tnfis associated disease activity national cohort rheumatoid arthritis patients methods patients identified first tnfi initiation index date corrona registry patients age onset comorbid psoriasis psoriatic arthritis fibromyalgia osteoarthritis excluded patients categorized disease activity strata lowest level sustaining low levels least two visits using clinical disease activity index cdai across visits corrona tnfi year initiation rates cause related hospitalizations rheumatologist visits joint surgeries tnfi therapy reported compared across levels along incidence rate ratio irr adjusted age gender duration using poisson mixed models results patients achieved sustained remission remission sustained low low moderate high hda hda statistically higher rates hospitalizations per patient years joint surgeries per compared sustained remission cohort resulting respective irrs conclusion many biologic naive patients initiating tnfi failed achieve sustained remission year period remaining tnfi therapy patients higher levels higher hcru rates patients sustained remission suggesting achieving treat target goals would reduce health care expenses
post stroke depression psd common psychiatric complication stroke associated poor outcome stroke patients aim assess association serum magnesium levels presence psd chinese patients two hundred nine stroke patients included study depressive symptoms measured hamilton rating scale depression months stroke based depressive symptoms diagnoses depression made line dsm criteria psd serum magnesium levels evaluated using dimethyl aniline blue colorimetric method admission multivariate analyses conducted using logistic regression models normal subjects recruited serum magnesium levels also measured control months fifty nine patients diagnosed psd serum magnesium levels significantly lower psd patients non psd patients normal subjects indeed patients psd showed lower serum magnesium levels non psd patients admission multivariate analyses adjusting potential variables found increased risk psd associated serum magnesium levels mmol low serum magnesium levels admission found associated presence psd months stroke
mesh parameterization one fundamental operations computer graphics computeraided design cad paper propose novel local global parameterization approach arap single multi boundary triangular meshes extension rigid possible arap approach stitches together ring patches instead individual triangles optimize spring energy introduce linear iterative scheme employs convex combination weights fitting jacobian matrix corresponding prescribed family transformations algorithm simple efficient robust geometric properties angle area original model also preserved appropriately prescribing singular values fitting matrix reduce area stretch distortions high curvature models stretch operator introduced numerical results demonstrate arap outperforms several state art methods terms controlling distortions angle area stretch furthermore achieves better visualization performance several applications texture mapping surface remeshing
background chronic kidney disease growing health problem global scale increasing prevalence chronic kidney disease presents urgent need better understand knowledge confidence engagement self managing disease objectives study examined group differences patient activation health related quality life knowledge self management confidence managing chronic disease across five stages chronic kidney disease design study employed descriptive correlational design settings participants recruited five primary care three nephrology clinics one dialysis centre two midwestern cities united states participants convenience sample included adults hypertension diabetes mellitus chronic kidney disease including kidney failure spoke english measurements seven measurements used collect data via telephone interviews participants receiving haemodialysis face face interviews receiving haemodialysis beginning treatment session results analyses indicated half participants female mean age years participants chronic kidney disease stage activated post hoc differences significant patient activation blood pressure self management anxiety across chronic kidney disease stages excluding stage conclusion engaging patients self management health care enhancing patients ability self manage blood pressure may work preserve kidney health healthcare providers collaborate patients develop strategies maintain patients health related quality life like reducing anxiety kidney disease progress
objectives aim study retrospectively evaluate effectiveness fertility awareness based method supported mobile based application prevent unwanted pregnancies method natural birth control methods retrospective analysis application efficiency contraceptive method examined data women used application contraception total woman years results number identified unplanned pregnancies woman years giving pearl index typical use ten pregnancies due application falsely attributing safe day within fertile window producing perfect use pearl index calculating cumulative pregnancy probability life table analysis resulted pregnancy rate per year confidence interval per year conclusions application appears improve effectiveness fertility awareness based methods used prevent pregnancies couples consistently protect fertile days
effectiveness layered geotextile protection layers comprised combinations nonwoven needle punched woven slit film nonwoven heat bonded geotextiles minimize strains landfill geomembranes examined results physical experiments reported sustained force applied diameter machined steel probe top protection layer diameter thick high density polyethylene geomembrane thick compressible clay layer experiments intended simulate physical conditions medium sized landfill average vertical stress kpa capture mean response nominal coarse gravel geomembrane screening tests first conducted temperatures degrees evaluate three different combinations layered geotextiles examined combination low slack heat bonded geotextile thick nonwoven needle punched geotextile central core found provide lowest strains time temperature superposition method developed validated means predict long term effectiveness promising layered geotextile composite last long term predictions tensile strain made compared proposed allowable limits despite encouraging results short term screening tests even promising layered geotextile composite recommended protection layer limit long term geomembrane strains particular force particle size materials examined predicted strain years degrees similar exceeds range currently proposed limits doi asce american society civil engineers
hiv hepatitis virus hcv share transmission routes including contaminated blood transfusion sexual intercourse needle sharing injection drug users idus obtained five near full length genome sequences hcv isolated five hiv coinfected idus sichuan xinjiang provinces china conducting reconstruction neighbor joining phylogenetic tree results revealed five isolates four different genotypes amino acid substitutions xjn related resistant protease inhibitors grazoprevir also identified genetic diversity sequences uncovered complicated transmission situation hcv among idus china
objectives restrictions sleep important adverse effects health job performance collected information sleep healthcare workers determine whether sleep difficulties methods used internet based survey collect information sleep patterns sleep quality healthcare workers tertiary care hospital classified workers short sleepers hours normal sleepers hours long sleepers hours compared three groups using simple descriptive statistics used logistic regression identify factors associated short sleep times results questionnaires distributed healthcare workers replied survey median age years median body mass index women median sleep duration weekdays hours sixty nine respondents short sleepers respondents normal sleepers respondents long sleepers total sleep difficulties time respondents bothered lack energy poor sleep short sleepers less likely types sleepers normal bedtimes regular mealtimes eighty four respondents went bed workers younger slept less weekdays weekends reported difficulty sleeping feeling depressed overconsumption alcoholic beverages personal stressors conclusions healthcare workers healthy sleep patterns however many workers poor sleep quality workers odd bedtimes abnormal sleep patterns abnormal sleep quality workers need additional evaluation understand causes consequences sleep patterns
oxidant antioxidant imbalance may contribute pathophysiology autism spectrum disorder asd assayed urinary levels oxidative stress related biomarkers hexanoyl lysine hel total antioxidant capacity taoc dna methylation biomarker hydroxy deoxyguanosine ohdg plasma levels superoxide dismutase sod major antioxidant enzyme examined relationship four biomarkers social responsiveness individuals asd healthy controls sex asd group control group age distributions asd group years control group years significantly different groups social responsiveness assessed using social responsiveness scale srs used standardized regression coefficients measure effect size asd group exhibited significantly lower urinary taoc levels significantly elevated urinary hel levels control group urinary ohdg levels plasma sod levels significantly different groups asd group showed significantly higher srs scores control group plasma sod levels correlated significantly urinary taoc levels standardized regression coefficients revealed taoc levels larger effect size hel levels urine study firstly reveals imbalance urinary hel taoc levels favor urinary taoc levels may contribute impaired social responsiveness individuals asd plasma sod levels may also affect urinary taoc levels
present study investigated whether gender differences death attitudes could attributable social desirability locus control disgust sensitivity total university students completed multidimensional fear death scale revised death attitude profile addition measures social desirability locus control disgust sensitivity women scored higher men many fear dimensions also approach escape acceptance gender differences locus control social desirability women reported disgust sensitivity men locus control unrelated death attitudes social desirability associated less reported fear premature death disgust sensitivity associated death attitudes except neutral acceptance gender differences death attitudes longer significant controlling disgust sensitivity
one design strategy iterate photocatalytic efficiency semiconducting nanomaterials harvesting solar energy involves synthesis type heterostructured materials article straightforward facile environmentally benign route heterostructures sno nanospheres capped pbs nanocubes reported offers address current limitations photocatalytic efficiency brought electron hole recombination narrow photoresponsive ranges many existing systems pbs nanocubes grown presence preformed sno nanospheres functionalizing surface latter using cetyltrimethylammonium bromide ctab heterostructure formation confirmed ray diffraction xrd raman spectroscopy ray photoelectron spectroscopy xps brunauer emmett teller bet surface area analysis transmission electron microscopy tem analysis rietveld refinement exploited simultaneously elucidate atomic microstructures materials allowing quantitative determination particle structure stability combination narrow band gap semiconductor pbs wide band gap semiconductor sno endows heterostructured nanomaterial potential photocatalyst degradation rhodamine rhb dye solar simulation showed superior photocatalytic activity separate sno pbs components strong type interaction demonstrated heterostructure charge separation mechanism utilized clarify behaviour authors published elsevier
software defined networking paradigm still emergent stages realm production scale networks centralisation network control introduces new level flexibility network administrators programmers security huge factor contributing consumer resistance implementation sdn architecture without addressing issues inherent sdns centralised nature benefits performance network configurative flexibility harnessed paper explores key threats posed sdn environments comparatively analyses mechanisms proposed mitigations threats also provides insight future works would enable securer sdn architecture
data mining preprocessing step considerable diversity candidate algorithms select important features according criteria broad availability algorithms perform feature selection task gives rise difficulty choosing priori algorithms hand promising one particular problem paper present proposal evaluation new architecture recommendation feature selection algorithms based use metalearning framework flexible since user adapt proper needs flexibility one main advantages proposal approaches literature involve steps adapted user local requirements furthermore combines several concepts intelligent systems including machine learning data mining topics derived expert systems user data driven knowledge meta knowledge set solutions coupled leading edge technologies allows architecture integrated information system impact automation services reducing human effort process regarding metalearning process framework considers several types properties inherent data sets well feature selection algorithms based many information distance dependence consistency measures quality methods feature selection estimated according multicriteria performance measure guided ranking process algorithms construction data metabases proposed authors work multicriteria performance measure combines three measurements single one creating interesting powerful tool evaluate algorithms also assess context necessary combination maximize measure minimize recommendation models represented decision trees induced training metabases allowed see circumstances feature selection algorithm outperforms aspects data present greater influence determining performance algorithms nevertheless user wishes learning algorithm may used induce recommendation model versatility another strong point proposal results show characterization data statistical information complexity measures possible reach accuracy higher besides yielding recommendation models interpretable robust overfitting developed architecture less computationally expensive approaches recently proposed literature elsevier ltd rights reserved
study analysed dietary intake people living hiv aids plwha rural communities imo state nigeria simple random sampling technique used sample plwha members two rural support groups high prevalence hiv imo state using interview schedule data analysed using descriptive statistics pearson product moment correlation test mean involvement agriculture reduced hiv infection extent involvement agriculture significantly reduced pre post hiv infection diet diversity score low among majority plwha mean diet adjudged severely inadequate however change level involvement agriculture significant correlation dietary intake study concluded diet plwha imo state inadequate thus need extension collaborate health sector develop nutritional guideline plwha rural communities
growing water scarcity global climate change call efficient alternatives water conservation rainwater harvesting rwh promising alternative among others however assessment rwh potential selection suitable sites rwh structures challenging water managers especially larger scales study addresses challenge presenting fairly robust methodology evaluating rwh potential identifying sites zones different rwh structures using geospatial multicriteria decision analysis mcda techniques proposed methodology demonstrated using case study remote sensing data conventional field data used prepare desired thematic layers using arcgis software distributed curve number method used calculate event based runoffs based annual runoff potential runoff coefficient maps generated gis geographic information system environment thematic layers slope drainage density runoff coefficient features assigned suitable weights integrated gis generate rwh potential map study area zones suitable different rwh structures also identified together suitable sites constructing recharge structures check dams percolation tanks along streams found study area classified three rwh potential zones good moderate poor study area suitable constructing farm ponds percolation tanks ground constructed area sites identified recharge structures recharge sites specially suited inhabitants proximity concluded integrated geospatial mcda techniques offer useful powerful tool planning rainwater harvesting basin sub basin scale elsevier rights reserved
paper presents overview examples material design development using classical thermodynamics calphad calculation phase diagrams modeling integrated computational materials engineering icme approaches although examples given lightweight aluminum magnesium alloys structural applications fundamental methodology modeling principles applicable materials engineering applications examples paper demonstrated effectiveness limitations classical thermodynamics solving specific problems nucleation solidification solid state precipitation aluminum alloys computational thermodynamics calphad modeling combined critical experimental validation used guide selection design new magnesium alloys elevated temperature applications future material design development based holistic icme approach however key challenges exist many aspects icme framework lack diffusion mobility databases many materials systems limitation current microstructural modeling capability integration tools simulation codes different length scales elsevier ltd rights reserved
qualitative analysis nonverbal communication relying recording technology however human analysis data regular screen challenging scenes difficult visually parse optimally exploit full depth data propose enhance view number visualizations clarify spatial conceptual relationships add derived data like speed angles paper present visualizations directional body motion hand movement direction gesture space location proxemic dimensions like interpersonal distance movement orientation proposed visualizations available open source tool jmocap planned fully integrated anvil video annotation tool described techniques intended make annotation efficient reliable may allow discovery entirely new phenomena
paper investigates challenges bodily communication video based clinical consultations previous works describe lack eye contact gestures video unclear limitations impact course clinical consultation particularly domain like physiotherapy focus improving body movements functioning contribute understanding conducted observations naturally occurring video face face consultations physiotherapy found clinicians rely variety incidental bodily cues fine details body movements assess examine patient bodily cues noticeable face face consultations however variety bodily cues got missed video consequently video consultations became conversational clinicians used verbal conduct get fair understanding patient health guide design future video consultation systems reflect understanding design sensitivities visual acuity field view clinical asymmetries time sequence
objective evaluate relationship systemic inflammation skin microcirculation patients rheumatoid arthritis ankylosing spondylitis methods assessed skin microcirculation flux laser doppler flowmetry classical cardiovascular risk factors inflammatory markers disease activity disease activity score bath ankylosing spondylitis disease activity index patients arthritis median disease duration years healthy subjects results patients arthritis inflammatory markers reactive protein interleukin fibrinogen increased peak flux velocity occlusion temperature degrees maximal heat flux velocity heating significantly lower findings accompanied slower increase flux rate local heating positive correlations inflammatory markers microcirculation parameters patients patients peak flux velocity disease activity significant intergroup differences classical cardiovascular risk factors compared except lower hdl cholesterol arthritis patients conclusions patients chronic systemic inflammatory arthritis presented altered microvascular function reduced vasodilator capacity forearm skin microcirculation
purpose paper determine physical electrical circuits impedance admittance forms match fractional order integrators differentiators namely using idealized infinite dimensional circuits energy storage loss expressions determined carefully relating associated infinite dimensional state variables physically meaningful quantities resulting realizations energy expressions allow variety implementations understanding transient behavior fractional order systems
adapting well known paradigm studying memory wordsthe deese roediger mcdermott drm paradigm deese roediger mcdermott two experiments reported explore memory song titles song clips participants presented five song titles experiment five second song clips experiment nine popular artists robbie williams popular song identified artist pilot task omitted sets titles clips following distractor task participants asked write many songs could recall also asked return week later complete second recall task participants falsely recalled significant number related non presented songs experiments increased week later correct recall presented items decreased results discussed terms theory musical memory well context providing novel method exploring organisation musical memory
two decades passed since start worldwide market oriented electricity sector reforms reforms varied terms structure market mechanisms regulation however passage time calls taking stock performance reforms developing countries paper surveys empirical literature electricity sector reforms draws conclusions view future overall reforms tended improve technical efficiency sector macroeconomic benefits reforms less clear remain difficult identify also gains reforms often trickled consumers institutional regulatory weaknesses order achieve lasting benefits reforms need adopt measures align pursuit economic efficiency equity provision access reforms deliver economic benefits alleviate poverty poor access electricity new technologies institutional capacity building help improve performance reforms
one possible research lines improving concentrated solar power csp technology enhancement thermophysical properties heat transfer fluids htf used enhancement leads reduce costs producing electricity using technology study presents preparation nanofluids nanoparticles added base fluid composed eutectic mixture diphenyl oxide biphenyl base fluid heat transfer fluid commonly used concentrating solar power plants nanofluids shown improved thermal properties heat transfer coefficient increasing compared base fluid thus use could lead enhancements overall efficiency csp plants accordingly nanofluids prepared varying nanoparticle concentrations properties characterized including physical chemical stability viscosity isobaric specific heat thermal conductivity addition molecular dynamic calculations performed reach better understanding nanofluid system molecular level isobaric specific heat thermal conductivity values followed experimental tendency analysis radial distribution functions rdfs spatial distribution functions sdfs shows first layer base fluid molecules around metal oxygen atoms play important role first layer encourages directionality movement heart nanofluid leads enhanced thermal properties elsevier ltd rights reserved
self regulation requires overriding dominant response leads temporary self regulatory fatigue existing theories nature causes self regulatory fatigue highlight physiological substrates glucose psychological processes motivation explanations incomplete historically theories physical fatigue demonstrate similar pattern useful incomplete explanations recent views physical fatigue emphasize roles physiological psychological factors addition accounting multiple inputs newer views also explain fatigue occur even presence sufficient resources examining newer theories physical fatigue serve foundation build comprehensive understanding self regulatory fatigue integrates possible neurobiological underpinnings physical self regulatory fatigue suggests possible function self regulatory fatigue
objective epidemiological studies suggest women loss ovarian function early ages may especially burdened cardiovascular disease cvd study aimed evaluate pulse wave velocity pwv myocardial performance index mpi patients premature ovarian insufficiency poi design enrolled female patients mean age years poi healthy subjects mean age years participants underwent detailed echocardiographic examination pwv measurement basically velocity pulse wave travelling carotid femoral artery results groups similar regard age body mass index bmi left ventricular ejection fraction diastolic functions assessed patients poi higher mean ratio poi patients impaired mpi comparing healthy controls pwv measurements differ two groups conclusions study showed poi patients might impaired global left ventricular functions comparing age matched healthy controls might reflect effects premature lack estrogen women cardiovascular system
study corrosion resistances aisi aisi borided non borided steels estimated using polarization resistance electrochemical impedance spectroscopy eis techniques boriding steel samples conducted using powder pack method exposure structural examinations surfaces borided steels showed presence feb layer isolated feb teeth aisi steel whereas compact layer feb feb formed aisi steel polarization resistance eis borided non borided steels surfaces performed corrosive solution hcl eis data analyzed days exposure acid solution impedance curves obtained period borided non borided steels modeled using equivalent electrical circuits results electrochemical techniques indicated boride layers formed steel surfaces effectively protect samples corrosive effects hcl main corrosion processes observed boride layers pitting crevice corrosion
numerous researchers determined building sustainability criteria relating environmental performance two sustainability components economic social performance taken consideration integrated hierarchical manner existing sustainability assessment methods generally ignore economic social aspects sustainable criteria prioritised facilitating decision making paper reports fuzzy analytic hierarchical process tool employed prioritise sustainability criteria residential buildings environmental economic social performance integrated manner structured expert based development process comprising building practitioners eight academics nations conducted globally fuzzy weighted hierarchy three aspects sustainability residential buildings developed end study assisted programmers hierarchy expected developed computer software near future improve construction management
study conducts age period cohort analysis religious involvement affects adult health across life course time usa cross classified random effect models used examine data drawn general social survey research shows clear life course patterns time trends birth cohort changes religious involvement health relationship period effects surpassing cohort effects part results show loss advantage health age involved religion period effects mainly demonstrated overall downward trend self rated health srh attributable religious denominational differences various levels social integration unlike period effects health disparities associated religious denominational differences fluctuated cohort progressed findings suggest general positive effect religious involvement srh decreases age periods influence individual srh fluctuates cohort expected downward trend srh attributable religious involvement carry future
gca common primary systemic vasculitis results granulomatous inflammation medium large arteries innate adaptive immune mechanisms combine drive intimal hyperplasia luminal stenosis ultimately occlusion pathogenesis gca incompletely understood activation resident adventitial dendritic cells via toll like receptors tlrs appears crucial inciting event explore role tlrs pathogenesis gca including effects dendritic cell cell activation recruitment putative infectious triggers gca potential tlr inhibition novel therapeutic strategy gca
paper argues spiritual leadership unique model followers well leaders become connected committed group wellbeing spirit filled way living positive transformation theories spiritual leadership thus functional leaders also followers provide essential motivation rediscover life filled pathways fulfilling group light follower identifies need bonds shares burden fulfil need qualifies spiritual leader person one empowered holy spirit become connected committed network drive goals organization initiate moves positive transformation paper uses narrative critical reading hannah story samuel support argument followers play key roles spiritual leaders
massive amounts data processed modern computational systems becoming problem increasing importance data commonly stored directly indirectly use data exchange languages javascript object notation json human readable platform agnostic access paper focuses describing analyzing sjson library explores succinct representations json documents means achieve reduced memory usage tiles main memory permit compression json files stored disk sjson represent document structure succinct trees opposed usual pointer based implementation furthermore remaining raw data organized arrays attributes values attributes stripped redundancies stored simple contiguous array values represented hit string indexed array scheme proposed evaluated respect number metrics comparing performance popular libraries possible improvements representation presented
paper new voltage mode first order pass filter apf topology composed grounded capacitor proposed proposed apf uses single minus type second generation current conveyor ccii constructed five mos transistors low power consumption resonance frequency proposed apf adjusted changing resistor value however needs single matching condition application quadrature oscillator example given non ideality analysis proposed apf also given number time domain frequency domain simulation results experimental test result included confirm theory sharif university technology rights reserved
main objectives load frequency control lfc regulate electrical power supply two area power system change system frequency tie line load performance lfc tuned properly performance optimised however tuning processes performed trial error best performance achieved therefore overcome situation work particle swarm optimization pso evolutionary particle swarm optimization epso algorithms employed lfc two area power system optimise performance pid controller purpose using pid controller improve performance lfc comparison performance using pso epso made identify algorithm better controlling performance lfc found using epso performance lfc better terms settling time rise time using pso hence implementing optimisation method performance lfc optimised optimising pid controller parameters
background overactive bladder syndrome condition one symptoms pollakiuria urgent need urinate nocturia urinary incontinence observed prevalence ranges men women role pharmacist educate patient medications administration scheme drug interactions particular food food components aim review assess potential impact food fruit juice pharmacokinetic therapeutic effects medications used treating overactive bladder syndrome information enhance pharmaceutical care vital helpful pharmacists counseling patients method order gather information interactions medications employed bladder dysfunctions english language reports published pubmed embase cochrane cinahl database years studied additionally resources namely drugs com medscape uptodate micromedex medical letter well stockley drugs interaction electronic publication included study analysis also covered product data sheets particular medicinal products results meals consumption grapefruit juice found exert diversified effect pharmacokinetics drugs employed overactive bladder syndrome therapy neither tolterodine mirabegron interact food citrus fruit juice whereas darifenacin fesoterodine oxybutynin solifenacin interact grapefruit others citrus fruit juice effects interactions may potentially negative patients trospium absorption significantly decreased food conclusion selected medicines used treating bladder dysfunctions food grapefruit juice consumption may significantly affect efficacy safety therapy information topic likely enhance quality pharmaceutical care
purpose purpose paper identify relative importance factors affecting quality important great expenditures time money resources wasted year due inefficient non existent quality levels design methodology approach exploratory approach employed literature review six interviews initially conducted construction experts simple survey questionnaires administrated structured personal interviews among contractors architects jordanian housing sector findings findings suggest contractors architects combined agreed highest important factors affecting quality human resource management customer satisfaction construction specific factors findings also suggest strategic planning continuous improvement resources lowest important factors conceptual framework encompassing key quality factors also developed research limitations implications research important implications different level managers construction companies understanding quality factors managers focus highest factors catch lowest important factors order maintain balanced integrated quality approach originality value one studies investigate importance quality factors authors knowledge first paper providing empirical evidence quality factors construction management developing country
secure data aggregation sda schemes widely used distributed applications mobile sensor networks reduce communication cost prolong network life cycle provide security however sda suited single type statistics summation based comparison based statistics applicable obtaining multiple statistic results sda also inefficient dynamic networks paper presents multi functional secure data aggregation mfsda mapping step coding step introduced provide value preserving order preserving later enable arbitrary statistics support query mfsda suited dynamic networks active nodes counted directly aggregation data proposed scheme tolerant many types attacks network load proposed scheme balanced significant bottleneck exists mfsda includes two versions mfsda mfsda first one obtain accurate results second one generalized version significantly reduce network traffic expense less accuracy loss
background aims hepatitis virus hcv infection following liver transplant associated reduced graft patient survival transplant sofosbuvir ribavirin sof treatment prevents recurrent hcv patients achieving viral suppression least weeks transplant evaluated whether bridging sof regimen pre post transplant safe effective prevent hcv recurrence patients less weeks hcv rna undetectability time transplant methods july sof given waitlisted hcv cirrhotics without hepatocellular carcinoma hcc within italian compassionate program one hundred patients transplanted patients treated sof bridging therapy studied results liver transplant indication bridge subgroup hcc decompensated cirrhosis hcv genotype patients sof day median dosage day given median days transplant time patients still hcv rna positive median hcv rna one recipient virological breakthrough week post transplant one died treatment month post transplant sepsis achieved week sustained virological response acute cellular rejection occurred three recipients september recipients alive median follow months range conclusions patients suboptimal virological response bridging sof regimen helps avoiding post transplant graft reinfection
silica titania uniformly coated multi walled carbon nanotubes mwnts fabricated using tetraethyl orthosilicate teos titanium butoxide tbt application electrorheological fluids electrorheological dielectric properties two different core shell nano tube based fluids measured using rheometer impedance analyzer titania coated mwnts fluids shown higher static yield stress well dynamic viscoelastic properties compared silica coated mwnts fluids external electric field silica titania coated mwnts fluids shown high permittivity short relaxation time interfacial polarization dielectric spectra measurement found permittivity electrical conductivity mwnts controlled coating either silica titania onto functionalized mwnts elsevier rights reserved
wireless mesh networks wmn growing rapidly research community due numerous applications shared services feature kind networks connectivity opens network diverse kinds attacks attacks generate extra traffic possibly carries unauthorized intrusions proposal ibw framework includes approach security wmn detecting mitigating attacks use non relational databases data correlation dissemination intrusion information among nodes wmn reduce amount attacks short time data correlation done log data servers distributed intrusion detection prevention systems idss ipss using syslog information particular format intrusion prevention systems implemented kind solution case proposed iptables finally case study presented using olsr routing protocol brute force attacks comparing proposal open source blocking tool failban whole scenario emulated dockemu generate similar attack patterns result comparison
background autophagy conserved molecular pathway involved degradation recycling cellular components active either response starvation molecular damage evidence emerging autophagy plays key role degradation damaged cellular components thereby affects aging lifespan control earlier studies found autophagy aging model podospora anserina acts longevity assurance mechanism however little known individual components controlling autophagy aging model report biochemical bioinformatics study detect protein protein interaction ppi network anserina combining experimental theoretical methods results constructed ppi network autophagy anserina based corresponding networks yeast human integrated paatg interaction partners identified yeast two hybrid analysis using atg anserina bait additionally included age dependent transcriptome data resulting network consists proteins involved interactions applied bioinformatics approaches analyze network topology prove network random exhibits biologically meaningful properties identified hub proteins play essential role network well seven putative sub pathways interactions likely evolutionary conserved amongst species confirmed autophagy associated genes significantly often regulated expressed aging anserina conclusions present study provide comprehensive biological network autophagy pathway anserina comprising ppi gene expression data based computational prediction well experimental data identified sub pathways important hub proteins evolutionary conserved interactions network clearly illustrates relation autophagy aging processes enables specific studies understand autophagy aging anserina well systems
compare sensitivity enhancing multiple sclerosis lesions gadolinium enhanced weighted gradient echo gre spin echo sequences assess influence visual conspicuity laterality detection lesions one hundred patients underwent brain mri including gadolinium enhanced weighted gre sequences two sets contrast enhanced scans evaluated random fashion three experienced readers lesion conspicuity assessed image contrast ratio contrast noise ratio cnr intracranial region divided four quadrants impact lesion location detection assessed slice six hundred seven gadolinium enhancing lesions identified gre images sensitive lesion detection images lesions showed higher gre images whereas cnr higher gre misclassifications occurred right posterior quadrant gadolinium enhanced weighted gre sequence mri enables detection enhancing lesions higher sensitivity better lesion conspicuity weighted hence propose use gadolinium enhanced gre sequences rather sequences routine scanning patients aeuro cent gre sequences useful detecting active lesions aeuro cent sequences sensitive high field remains uncertain aeuro cent gre sequence showed better sensitivity detecting active lesions aeuro cent propose gre sequence detecting active lesions
work deals evaluation aqueous concentrations dissolved reactive phosphorus drp total phosphorus ammonium nitrogen surface water means direct online instrumentation portable submersible automated analyzer designed measure dissolved total nutrient concentrations characterized miniaturization entire analytical process tested laboratory methods total number water samples different origin rain river lake sewage waters analyzed used comparison drp data raw data distributed broad range concentrations drp regression analysis underlined high significant correlation measures probe laboratory pointed effectiveness new instrument representing broad range nutrient concentrations
objective recent studies indicate increased cardiovascular morbidity mortality patients psoriatic arthritis psa results inconsistent prompted investigation mortality rate cause death incidence acute events patients northern sweden psa methods patients established psa included calculate standardized mortality ratio smr standardized incidence ratio sir events data extracted national causes death register national inpatient care register sweden compared general population study period study effect inflammatory activity composite disease activity index dai used results smr overall mortality diseases circulatory system international classification diseases edition respectively regression analysis dai significantly associated death adjusted age sex remained significant stratifying patients major causes death diseases circulatory system malignant neoplasms peripheral axial disease associated death compared peripheral disease sir event myocardial infarction stroke association significant men conclusion patients psa small significant increase smr death due diseases circulatory system compared general population among patients death associated dai well axial involvement combination peripheral disease indicating aggressive disease phenotypes
background personality disorder associated elevated suicide risk level risk primary care settings unknown assessed whether among primary care patients linked greater elevation risk compared psychiatric diagnoses whether association modified gender age type comorbid alcohol misuse methods using data clinical practice research datalink suicides matched living controls gender age registered practice prevalence mental disorders alcohol misuse calculated cases controls separately conditional logistic regression models used estimate exposure odds ratios also fitted gender interaction terms formally tested significance estimated gender age specific effects results found fold increase suicide risk patients versus recorded psychiatric disorder four fold increase versus psychiatric illnesses combined borderline comorbid alcohol misuse associated fold increased risk respectively compared psychiatric disorders relative risks higher female male patients significant risks associated diagnosis identified across age ranges although greatest elevations younger age ranges years conclusions large elevation suicide risk among patients diagnosed comorbid alcohol misuse particular concern gps potentially key role play intervening patients diagnosed particularly presence comorbid alcohol misuse may help reduce suicide risk would mean working specialist care agreed clinical pathways availability services comorbidities alcohol misuse well opportunities gps develop specific clinical skills
flexible multi generation systems fmgs consist integrated flexibly operated facilities provide multiple links different sectors energy system present study treated design optimization conceptual fmg integrated methanol producing biorefinery existing combined heat power chp unit industrial energy utility supply danish city horsens objective optimize economic performance minimize total emission fmg required meet local district heating demand plus thermal utility demand butchery design optimization considered selection dimensioning location integration processes operation optimization respect hourly variations operating conditions year well expected long term energy system development uncertainty analysis considering investment costs operating conditions applying previously developed fmg design methodology scalable models considered processes developed system design optimized respect hourly operation period optimal design respect economic environmental performance involved maximum sized biorefinery located next local industry rather connection existing chp unit local industry energy demands limited compared biorefinery dimensions considered process integration synergies found marginal compared economic environmental impact biorefinery present case assessing impact uncertainties estimated fmg performances net present value npv optimal design estimated vary within range response changes investment costs methanol price considering two different electricity price scenarios addition change interest rate found reduce lower bound npv reference operating conditions results suggest applied interest rate operating conditions particular methanol price would much higher impact economic performance designs corresponding uncertainties investment costs addition study outcomes emphasize importance including systematic uncertainty analysis design optimization fmg concepts elsevier ltd rights reserved
since photovoltaic generators mechanical inertia fast solar irradiance changes associated cloud transients cause instantaneous variations power output resulting rapid possibly significant voltage changes systems high penetration generators addition characterizing emerging power quality issue paper proposes investigates techniques mitigate fast voltage variations caused cloud transients distribution system solar farms investigated approaches based inverter capacity fast reactive power compensation without need oversize inverter curtail active power using available reserve real measurement data characterize issue time series power flow simulations evaluate mitigation techniques
background domination biomedical approach menopause may imply creation negative attitudes phenomenon time negatively affect women life satisfaction behaviour family assumed physical activity may defensive factor type activity may reduce intensity menopause symptoms aim research determine relation menopause evaluation life satisfaction tactics influence employed marriage women differ involvement physical exercise participants procedure research conducted among women age physically active women women engage physical activity following research methods used menopause evaluation scale satisfaction life scale swls questionnaire influence close relations women men results positive evaluation menopause related involvement physical exercise well stronger tendency use positive strategies exerting influence one spouse research also showed slight correlation life satisfaction involvement physical exercise negative evaluation menopause related avoiding physical activity conclusions physical activity frequently related positive attitude towards menopause use positive tactics exerting influence one spouse slightly positively conducive one life satisfaction level
paper consider structure symmetry group important mechanical theories nonlinear elasticity fluids grade discuss invariance respect well known transformations must used care explain universal transformations useless obtain invariant solutions physical significance elsevier ltd rights reserved
epidemiological studies demonstrated patients suffering overactive bladder often present different mental problems amongst depression frequently observed main goal study check repeated administration corticosterone cort able evoke depressive like behaviour detrusor overactivity symptoms rats moreover investigated whether acute administration common antidepressants imipramine fluoxetine antimuscarinic oxybutynin chloride crf antagonists impact cystometric parameters behaviour porsolt test overall locomotor activity animals exposed cort experiments carried female wistar rats applied surgical histopathology procedures cystometric investigations locomotor activity forced swim measurements fully described published literature fourteen day administration cort may induce depressive symptoms rats reversed inhibition crf receptors seems crf receptor could interesting target overactive bladder pharmacotherapy particularly patients existing depression
paper deals vector ito stochastic integral equations replace parameter deterministic model rlc electrical circuit stochastic one adding noise term coefficient introduce stochastic model circuit second order stochastic differential equation ito calculus solve equation numerical simulations stochastic trajectories present euler milstein numerical schemes used matlab computations stochastic trajectories examples
insect pathogenic fungus metarhizium anisopliae important insect biological control agent commercialized use worldwide fungal infection percutaneous rapid germination growth linked virulence using simple vitro growth screen isolate mutants increased virulence anisopliae conidia exposed radiation min mutants subsequently screened rapid growth standard potato dextrose agar screen colonies mutants selected based larger colony diameters compared wild type parent insect bioassays using diamondback moth plutella xylostella revealed one mutant designated mauv displaying rapid growth increased virulence mean lethal time kill using conidia mauv mutant wild type strains respectively total conidial production thermal tolerances mauv strain increased reduced secretome seen mutant compared wild type analyses culture supernatants indicated significant shifts secondary metabolite production mutant insecticidal activity ethoac extracts derived mauv mutant cell free culture supernatants similar times potent wild type extracts data indicate mutagenesis coupled growth screen simple approach isolate strains greater stress resistance virulence cell free extracts may hold promise alternative living organism insect control
psychological adaptation following homicide loss prove challenging grievers types losses although social support beneficial bereavement research mixed terms identifying whether serves buffer distress following traumatic loss particular studies parsed specific domains social support best predict positive bereavement outcomes recruiting sample african americans bereaved homicide examined six types social support along griever perceived need satisfaction analyzed relation depression anxiety complicated grief posttraumatic stress disorder outcomes results multivariate analyses revealed griever level satisfaction physical assistance initial assessment best predicted lower levels depression anxiety posttraumatic stress disorder levels months later less need physical assistance predicted lower complicated grief follow clinical implications suggestions future research discussed
introductionthe danish national birth cohort dnbc contains comprehensive information diet lifestyle constitutional major characteristics women pregnancy provides unique source studies health consequences gestational diabetes mellitus aim identify validate gestational diabetes mellitus cases cohort material methodswe extracted clinical information hospital records pregnancies included danish national birth cohort diagnosis diabetes pregnancy registered danish national patient register danish national birth cohort interview pregnancy validated diagnosis gestational diabetes mellitus randomly selected pregnancies entire danish national birth cohort individual hospital records expert panel evaluated gestational diabetes mellitus status based results oral glucose tolerance tests fasting blood glucose hbc values well diagnoses made local obstetricians resultsthe audit categorized pregnancies gestational diabetes mellitus corresponding pregnancies pregnancy interview self reported diabetes pregnancy available randomly selected group combined information register interviews could correctly identify cases entire danish national birth cohort population positive predictive value however conclusionsthe combined use data register interview provided high sensitivity gestational diabetes mellitus diagnosis low positive predictive value however suggests systematic validation hospital record review essential underestimate health consequences gestational diabetes mellitus future studies
would advantage measurement method would provide detailed spatial information water contaminations low cost hyperspectral remote sensing possibility gathering detailed contamination information rapidly inexpensively study includes possibility assessing heavy metal contamination water mariut lake predicting models describe concentration using spectrum data taken portable fieldspec asd spectroradiometer main objectives research assessing water contamination heavy metal mariut lake using laboratory analysis developing predictive model water pollution based spectral characteristics lab data obtained resulted concentrations exceed permissible limit usepa also spectral reflectance wavelength related spectral behavior high chlorophyll concentration also samples showed high low values turbidity suspended sediment concentration increased reflectance also increased wavelengths concluded models predicting heavy metals concentration using reflectance spectroscopy high significant correlation ranged national authority remote sensing space sciences production hosting elsevier open access article license http creativecommons org licenses ncnd
physical activity recommended axial spondyloarthritis axspa may insufficiently performed objective study assess physical activity axial spondyloarthritis explore explanatory factors cross sectional study patients definite axspa level physical activity international physical activity questionnaire long form ipaq type aerobic exercise exercise benefits barriers score collected multivariate logistic regression analyses performed explain levels exercise least recommended world health organization patients included mean age years males mean bath ankylosing spondylitis activity index treated tnf inhibitors patients exercising least recommended high physical activity category aerobic exercise min performed least week patients frequent activities energetic walking swimming main perceived benefits exercising improving physical fitness functioning cardiovascular system main barrier physical exertion patients paid employment lower levels physical activity whereas demographic variables disease activity severity tnf inhibitor treatment predictive one half patients performed enough physical activity according recommendations similarly french population levels physical activity appear explained disease related variables physical activity encouraged axspa
measurements accelerometers originally deployed measure building structural dynamics serve new role locating individuals moving within building specifically paper proposes measurements footstep generated vibrations novel source information localization complexity wave propagation building dispersion reflection limits utility existing algorithms designed locate example source sound room radio waves free space paper develops enhancements arrival time determination time difference arrival localization order address complexities posed wave propagation within building structure experiments actual measurements instrumented public building demonstrate potential locating footsteps sub meter accuracy furthermore paper explains forecast performance buildings different sensor configurations localization capability holds potential assist public safety agencies building evacuation incidence response facilitate occupancy based optimization heating cooling inform facility security elsevier ltd rights reserved
depression anxiety disorders leading cause sickness absence long term work incapacity developed countries present study aimed carry systematic meta review examining effectiveness workplace mental health interventions defined intervention workplace may either initiate facilitate aims prevent treat rehabilitate worker diagnosis depression anxiety relevant reviews identified via detailed systematic search academic grey literature databases articles subjected rigorous quality appraisal using amstar assessment articles identified studies met inclusion criteria deemed moderate high quality together reviews analysed primary research studies moderate evidence identified two primary prevention interventions enhancing employee control promoting physical activity stronger evidence found cbt based stress management although less evidence found secondary prevention interventions counselling strong evidence also found routine use debriefing following trauma tertiary interventions specific focus work exposure therapy cbt based problem focused return work programmes strong evidence base improving symptomology moderate evidence base improving occupational outcomes overall findings demonstrate empirically supported interventions workplaces utilize aid prevention common mental illness well facilitating recovery employees diagnosed depression anxiety
mechanical characteristics nonwoven geotextile materials depend structural constructional solutions well technological development conditions addition important role structural physical mechanical properties fiber mass per unit area geotextile density needle punching production process paper presents results analysis mechanical properties nonwoven geotextile materials mass per unit area glm intended road construction breaking characteristics geotextile materials made regular recycled polyester fibers analyzed characteristic breaking strength geotextile materials measured dynamometer zwik results analyzed software testxpert obtained results defined relation force elongation rheological models developed used simulate behavior nonwoven geotextile materials regular recycled pes fiber exploitation
dysregulation intestinal epithelial barrier genetically susceptible individuals may lead intestinal extra intestinal autoimmune disorders emerging literature role microbiota changes pathogenesis systemic rheumatic diseases rheumatoid arthritis spondyloarthr opathies connective tissue diseases although role gastrointestinal tract pathogenesis spondyloartr opathies well defined many studies underline importance gastrointestinal inflammation modulating local systemic inflammation data inconclusive regarding effect dysbiosis rheumatoid arthritis connective tissue diseases review aims summarize current data role gastrointestinal involvement intestinal microbiota pathogenesis systemic rheumatic disease elsevier ltd rights reserved
new horizons images pluto companion charon show variety terrains display extensional tectonic features relief surprising relatively small world features suggest global extensional areal strain order early charon history extension consistent presence ancient global ocean frozen authors published elsevier inc open access article license
hercilio luz suspension bridge built service since due high corrosion levels structural element impairment complete rehabilitation project developed included replacement impaired items foundation strengthening auxiliary structure employed support central span rehabilitation process carefully studied load transfer process central span loading transferred eye bar towards auxiliary structure performed purpose synchronized jacking sequence used predefined means numerical model analysis structural elements designs evaluated geometric changes implemented paper presents methodology developed rehabilitation project hercilio luz bridge well development stages present date
multicultural society germany also impact healthcare system regardless country origin denomination migrants entitled high quality emergency medical care equal access facilities services german healthcare system literature review evaluation results care foreign patients necessary emergency physician aware potential sources miscommunication causes misunderstandings often due verbal communication however misunderstandings start earlier also relate nonverbal communication misunderstandings rescue personnel interact foreign patients found verbal level two forms insufficient language skills called organ metaphors prevent understanding content message language barriers communicating foreign patients present three alternatives communication via universal language english communication interpreter use visual communication aids verbal communication restricted possible nonverbal communication usually help culturally sensitive care achieved subject intercultural competence increasingly implemented education training develop culturally sensitive patient care change development processes required several levels must involve parties concerned
study used qrt pcr examine variation expression myogenes muscle development four prenatal periods days post insemination commercial three way duroc landrace large white cross local piau pig breeds differ muscle mass variation expression chd eidb hifan ikbkb rspo sox sufu genes various prenatal ages breeds mapk rbm genes showed similar expression commercial piau pigs greater expression least one prenatal period pair wise comparisons prenatal periods breed showed csrp lef mras myog genes higher expression least one prenatal period commercial piau pigs overall results identified lef gene primary candidate account differences muscle mass pig breeds since activation gene may lead greater myoblast fusion commercial breed compared piau pigs fusion could explain different muscularity breeds postnatal periods
rotator cuff tears common result considerable morbidity tears within tendon substance insertion humeral head represent considerable clinical challenge hostile local environment precludes healing tears often progress without intervention current surgical treatments inadequate although surgical implants instrumentation techniques improved healing rates improved high failure rate remains large massive rotator cuff tears use biologic adjuvants contribute regenerative microenvironment great potential improving healing rates function surgery article presents review current emerging biologic approaches augment rotator cuff tendon muscle regeneration focusing scientific rationale preclinical clinical evidence efficacy areas future research current barriers advancement implementation
selective catalytic reduction scr nitrogen dioxide air flow modeling exhaust gas internal combustion engine studied granulated mno alo powder avk catalyst ammonia injected scr catalytic cell used heterogeneous catalyst reduction reducing agent respectively efficiency removal high enough satisfies requirements state sanitary standards maximum permissible concentrations substances emitted atmosphere reducing agent ammonia completely consumed scr considerable amount released atmosphere therefore strict control unreacted ammonia emissions needed dependences concentrations ratio model air flow passed avk granular heterogeneous catalyst measured found maximum degree removal air takes place conventional process concentration drop time ammonia concentration increases becomes times remove unreacted ammonia air flows developed center dot sulfocationites ions styrene divinylbenzene copolymer shown concentration ammonia passed adsorption cell filled freshly sulfocationite drops dependences dynamic exchange capacity dec ammonia breakthrough center dot delta sulfocationite air flow rate concentration humidity measured maximum value dec delta observed air flow velocity humidity illustrate practical applications proposed improved scr method shown replaceable center dot sorbent cartridge scr exhaust gas purifier car internal combustion engine need replacement frequently every
several studies demonstrated mothers intellectual disability higher prevalence mental health illness lower socio economic status higher risk alcohol drug use compared mothers without children mothers represented child protection legal proceedings generally less studied group mothers aim study investigate children born mothers increased risk diagnosed mental illness injuries violence compared children mothers without study comprised population based cohort children born sweden data collected medical birth register linked two national registers icd codes used medical diagnoses including children followed birth seven years age total children included born mothers children mothers greater risk mental health problems adjusted odds ratio confidence interval early childhood increased risk injuries due falls largest risk related trauma violence child abuse conclusion children mothers increased risk injuries violence child abuse therefore suggest parents receive evidence based support children receive best care protection author published elsevier ltd
rice important staple food half world population demand expected increase increasing population developing countries mainly asia green revolution technologies transformed agricultural practices resulting considerable increase productivity rice later part twentieth century however rice agriculture currently faced multiple challenges declining stagnant yields lack water availability contamination natural resources due excessive use agrochemicals biodiversity losses greenhouse gas emissions losses due extreme climatic events strong need adapt agricultural practices order increase production rice manner economically viable environmentally sustainable review technologies already available could contribute significantly towards achievement objective using modern high throughput technologies breeders developing rice varieties possess traits climate resilience along higher yields effective management limited water resources high value rainwater harvesting groundwater recharge timing paddy transplantation onset rain greatly contribute towards sustainability rice production well maintained canal system could reduce seepage losses agronomic practices like laser levelling fields dry seeding alternate wetting drying known considerably reduce irrigation water requirement system rice intensification advocated increase rice yields halving water requirement input costs particularly resource poor conditions integrated nutrient management adjustment fertilizer dosage placement application timings increases nutrient use efficiency minimising degradation natural resources runoff leaching integrated pest management observation threshold values could reduce environmental health costs undesired effects non target organisms development pesticide resistance residues food products along minimising input costs obtain fullbenefit available technologies strong commitment extension policy institutions highly important use modern information technologies timely communication information weather forecast could assist farmers decision making various farming activities
taxes beneficial society depends revenue generated taxation provide essential public services education health care taxes also attract high degree loathing tax noncompliance major problem governments worldwide hundreds billions potential tax revenue uncollected year therefore critical research examine factors encourage tax satisfaction research hypothesized people would inclined view taxation favorable light believed wealth incurs responsibility give back society wealth responsibility consistent prediction study people reported stronger wealth responsibility beliefs felt better paying taxes study individuals assigned read text encouraging idea wealth incurs responsibility give back society felt better paying taxes compared neutral control group study individuals assigned read text encouraging wealth responsibility felt better paying taxes earned income lab together studies show reframing meaning wealth shape people attitudes paying taxes thus providing evidence novel lever encourage positive attitudes taxation elsevier rights reserved
heterogeneous networks tcp connections incorporate terrestrial satellite radio link greatly disadvantaged respect entirely wired connections longer round trip times rtts cope problem new tcp proposal tcp hybla presented discussed paper stems analytical evaluation congestion window dynamics tcp standard versions tahoe reno newreno suggests necessary modifications remove performance dependence rtt tcp hybla performance firstly evaluated case ideal channel good correlation analytical simulation data realistic situations require adoption benchmark network topology careful simulation set examined particular tcp hybla performance compared achievable tcp standard presence congestion link losses either separately jointly considered examined cases superiority tcp hybla evident greatly reduces severe penalization suffered wireless especially satellite tcp connections finally worth noting tcp hybla infringe end end semantics tcp compatible promising enhancements copyright john wiley sons ltd
backdrop non ideal political legal conditions article examines health capability paradigm principles help determine aspects health care might legitimately constitute positive health care rights indeed human rights even best approach equitable health care provision article addresses long american preoccupation negative rights rather positive rights health care positive health care rights exception overall moral range general thrust legal doctrine positive rights health care arisen constitutional eighth amendment cases federal state laws like medicare medicaid state children health insurance program emergency medical treatment active labor act patient protection affordable care act finally article discusses difficulties inherent implementing positive right health care
background indigenous canadians high rates risk factors chronic kidney disease ckd particular diabetes furthermore increased rates complications associated ckd kidney failure vascular disease objective describe prevalence ckd population study design cross sectional cohort setting participants indigenous first nations canadians years older screened part first nations community based screening improve kidney health prevent dialysis finished project initiative completed accomplished community wide screening rural communities manitoba canada predictors indigenous ethnicity geographic location communities accessible road compared accessible air outcome prevalence ckd presumed based single ascertainment urine albumin creatinine ratio uacr estimated glomerular filtration rate egfr egfr min communities accessible road lower prevalence ckd remote communities accessible air screened reduced kidney function defined egfr min severely increased albuminuria present screened limitations presumption chronicity based single ascertainment possibility sampling bias net direction uncertain conclusions found fold higher prevalence ckd indigenous canadians comparison general population prevalence severely increased albuminuria fold higher comparable patients diabetes hypertension public health strategies screen triage treat canadian indigenous peoples ckd considered national kidney foundation inc
backward forward coupled ring transmission line pass phasers presented general characteristics operation principles typical group characteristics discussed using ideal circuit simulations first configuration based contra directional backward coupling perfectly tem second configuration based non tem directional forward coupling radiofrequency counterpart optical ring resonator coupling compared conventional end connected coupled line phasers group delay swings proposed phasers inversely proportional involved coupling coefficients thus represent practically promising devices high resolution realtime radio
psoriasis psoriatic arthritis associated significantly increased risk cardiovascular risk factors major adverse cardiovascular events mace active research ongoing elucidate relationship psoriatic diseases cardiovascular comorbidities well shared pathogenic mechanisms review focuses epidemiologic association psoriasis cardiovascular risk factors epidemiologic association psoriasis mace epidemiologic association psoriatic arthritis cardiovascular risk factors mace proposed mechanisms contribution psoriatic diseases cardiovascular diseases proposed mechanisms shared pathogenesis psoriatic diseases cardiovascular diseases inflammation insulin resistance dyslipidemia angiogenesis oxidative stress endothelial dysfunction complex interplay overlap among mechanisms contributions shared pathogenesis future translational research necessary elucidate link psoriatic diseases cardiovascular diseases findings may applied clinically improve lives psoriasis patients
multimodal electrochemical technique incorporating open circuit potential ocp amperometric techniques conceptualized implemented improve detection specific analyte systems one analyte present approach demonstrated detection ethanol eliminating contribution water micro fuel cell sensor system sensor interfaced lmp potentiostat controlled mspflp microcontroller implement auto calibration algorithm tailored improve detection alcohol sensor designed fabricated three electrode system nafion proton exchange membrane pem electrochemical signal interfering phase water eliminated implementing multimodal electrochemical detection technique results validated comparing sensor potentiostat performances commercial sensor potentiostat respectively results suggest sensing system detect ethanol concentrations low ppm structure properties low detection limit selectivity miniaturized size enables potential application device wearable transdermal alcohol measurements elsevier rights reserved
paper presents novel scheme diagnose single double faults linear analog circuits scheme first proposes simple transformation procedure transform tested linear analog circuit discrete signal flow graph constructs diagnosing evaluators model faulty components form diagnosis configuration diagnose faults digital simulation saves much computation time furthermore simple method power also proposed differentiate equivalent faults scheme diagnose faults passive components well active faults
present method design deformation behavior printed models interactive tool variation bending elasticity different regions model realized change shell thickness given soft material used printing propose experimental setup acquire bending behavior material tubes different diameters thicknesses relationship shell thickness bending elasticity stored echo state network using acquired dataset help network interactive design tool developed generate non uniformly hollowed models achieve desired bending behaviors effectiveness method verified models fabricated different printers studying whether physical deformation match designed target shape
photovoltaic energy conversion thermodynamic system converts solar energy electrical thermal energy paper novel thermodynamic model photovoltaic energy conversion system proposed basis first second law thermodynamics including entropy generation optical thermal spectral fill factor losses based irreversibilities proposed model classified four cases reversible endoreversible exoreversible irreversible systems expressions energetic exergetic efficiencies derived upper limit efficiency ideal photovoltaic module placed irreversible environment endoreversible system determined effect wind speed module temperature energetic exergetic efficiencies thermodynamic losses irreversibilities also presented elsevier ltd rights reserved
significant decreases hormonal levels menopause induce physiological functional discomfort skin representative changes menopause based called dry skin however evidence explain mechanism even though hydration stratum corneum women menopause comparable premenopause enhanced hormone replacement therapy study objective evaluate structural functional changes ovariectomized mice model menopause hydration recovery permeability barrier function integrity cohesion irritant dermatitis analysed mice underwent ovariectomy without replacement estradiol ovariectomized mice hydration reduced recovery permeability barrier function acute disruption impaired integrity weakened associated increased cohesion increased levels irritant dermatitis oestrogen replacement treatment restored changes immunohistochemistry revealed reduced levels expression desmoglein differentiation markers epidermis ovariectomized mice compared control mice mice oestrogen replacement treatment changes might directly associated weakened integrity impaired permeability barrier function ovariectomized mice study results reveal called dry skin menopause caused lower hydration also complicated structural functional changes skin
hippocampus one interesting studied brain regions involvement memory functions vulnerability pathological conditions neurodegenerative processes recent years increasing availability magnetic resonance imaging mri scanners operate ultra high field uhf static magnetic field strength opened new research perspectives compared conventional high field scanners systems provide new contrasts increased signal noise ratio higher spatial resolution thus may improve visualization small structures brain hippocampal subfields studying morphometry hippocampus crucial neuroimaging research changes volume thickness hippocampal subregions may relevant early assessment pathological cognitive decline alzheimer disease present review provides overview manual semi automated fully automated methods allow assessment hippocampal subfield morphometry uhf mri focusing different hippocampal segmentation produced wiley periodicals inc
research aimed reduce excessive dust concentration flat chambers explore main factors affecting dust motion based theory gas solid two phase flow airflow field physical model established numerical simulation results dust concentration distributions flat chambers came fluent fluid mechanics computational software basically concordant experimental data research results showed following aspects main factors affecting dust motion flat chambers laid jet flow zone reflux zone mean flow velocity flat chambers ranged similar increases mean flow velocity resulted decreases dust concentration increase distance away working faces air flow velocity dust concentrations undulated appeared downward trend cross sections circulation jet flow reflux resulted elimination dust flat chambers
across eight jurisdictions australia mandatory reporting obligations thresholds reporting vary teachers one group professionals mandated report child maltreatment yet teachers still reluctant make report paper examines barriers discourage teachers reporting child maltreatment also whether teachers consider necessary question child maltreatment decide report made thirty semi structured interviews victorian primary school teachers thematically analysed revealed inadequate inconsistent mandatory reporting training need certainty initiating report ambiguous concept neglect barriers teachers identifying reporting child maltreatment analyses revealed teachers gather evidence confirm disconfirm suspicions maltreatment questioning suspected child victim consequences practice discussed along recommendations help overcome barriers making formal report child maltreatment suspected
objective aim study evaluate utility emergency department observation unit edou neurologically intact children closed head injuries chis computed tomography abnormalities methods retrospective cohort study children aged years acute chi abnormal head glasgow coma scales score higher admitted edou tertiary care children hospital children multisystem trauma nonaccidental trauma previous neurosurgical coagulopathic conditions excluded medical records abstracted demographic clinical radiographic findings poor outcome defined death intensive care unit admission medically surgically treated increased intracranial pressure results two hundred two children included median range age days years months male common findings nondisplaced displaced well skull fractures subdural hematomas less finding common interventions included repeat antiemetics pain medication eighty nine percentwere discharged less hours inpatient admission edou occurred discharged less days one patient required additional intervention corticosteroid therapy subdural hematoma persistent vomiting intractable headache nonevolving conclusions neurologically intact patients initial evaluation low likelihood requiring interventions irrespective findings although prospective evidence necessary supports reliance clinical findings evaluating well appearing child acute chi
paper presents study encryption algorithms identification means machine learning techniques plain text files written seven different languages encoded seven cryptographic algorithm ecb mode resulting cryptograms submitted transformation possible create metadata files files provide information six data mining algorithms order identify cryptographic algorithm used encryption identification performance evaluated language influence procedure analyzed overall experiment involves many cryptograms great quantity metadata huge time consuming computation therefore employed high performance computer successful identification mining algorithm greater probabilistic bid several scenarios algorithm identification reaches almost full recognition
analytes elute yield nearly identical electron ionization mass spectra well analytes yield nonspecific fragmentation patterns identified using fully integrated gas chromatography direct deposit fourier transform infrared detection mass spectrometric detection detector proved selective identifying analytes synthetic cannabinoids weight loss drugs limited relatively high detection limit parts per million ppm non targeted identification sibutramine based single injection reduced parts per billion ppb targeted identification sibutramine redepositing ten injections along track detector less selective identifying analytes yielded non targeted targeted detection limits approximately ppb ppb respectively corresponded fold advantage compared detector overall results study demonstrate advantages detector compensate limitations allows wider range analytes concentrations examined using fully integrated instrument compared examined using independently approach reduce consumption laboratory resources time provides information sample important forensic analyses require data two orthogonal techniques make identification
using discrete gpus processing large datasets challenging particular algorithm exhibit unpre dictable data driven access patterns paper investigate utility gpufs library provides direct access files gpu programs implement algorithms analyze system bottlenecks suggest several modifications gpufs design including new concurrent hash table buffer cache highly parallel memory allocator also show implementing workload warp centric manner improve performance even evaluate changes plementing real image processing application creates collages dataset million images enhanced gpufs design improves application performance average original gpufs performs core parallel cpu uses avx instruction set standard cuda based gpu implementation respectively significantly enhancing system programmability simplifying application design implementation
human prosociality traditionally explained social sciences terms internalized social norms recent neuroscientific studies extended traditional view human prosociality providing evidence prosocial choices economic games require cognitive control impulsive pursuit self interest however view challenged intuitive prosociality view emphasizing spontaneous heuristic basis prosocial choices economic games assessed brain structure players ultimatum game dictator game measured strategic reasoning ability according reflective norm enforcement view prosociality capable strategically controlling selfish impulses give fair share cognitive control capability affect behavior conversely support intuitive prosociality view showing first time knowledge strategic reasoning cortical thickness dorsolateral prefrontal cortex related giving negatively related giving implies uncontrolled choice prosocial rather selfish thicker dorsolateral prefrontal cortex capable strategic reasoning goal directed use theory mind control intuitive drive prosociality means maximize reward future implications choices
grey water footprint refers volume water required assimilate polluted water reflects intensity water pollution caused water use human activities study aims address major shortcomings associated grey water footprint accounting literature discuss several ways towards improvement global maize production used illustration study specifically tackles three issues appropriate water quality standards grey water footprint assessment grey water footprint multiple pollutants influence spatial resolution assessment level grey water stress biophysical crop model applied quantify nitrogen phosphorus losses water maize production global scale degree spatial resolution study shows grey water footprint calculation highly sensitive water standards applied results also suggest grey water footprint relating nitrogen phosphorus pollution caused maize production alone already exceeded local water availability many parts world grey water stress shows critical situation grid level watershed level maize cultivation former represents local concentration whereas latter gives average situation whole watershed study highlights need standardizing setting water quality standards consistent grey water footprint assessment taking consideration diverse aquatic ecosystems ambient water quality requirements across regions well presence multiple pollutants water bodies elsevier ltd rights reserved
background risk predicting models applied idiopathic pulmonary fibrosis ipf still validated patients rheumatoid arthritis associated interstitial lung disease ild purpose study test suitability three prediction models well individual lung function demographic factors evaluating prognosis ild patients methods clinical radiological data ild patients assessed gap gender age physiologic variables modified interstitial lung disease ild gap well composite physiologic indexes cpi tested predicting mortality using goodness fit test cox model potential predictors mortality also sought single lung function parameters clinical characteristics results median survival months gap ild gap stages gap ild gap models accurately estimated year year year mortality cpi gap ild gap scores age baseline diffusion capacity carbon monoxide dlco hospitalization due respiratory reasons significant predictors mortality univariate analysis whereas forced vital capacity fvc predictive cpi score baseline dlco remained significant predictors mortality adjusting age conclusions gap ild gap applicable evaluating risk death patients ild similar manner ipf baseline dlco cpi score also predicted survival
present new method decomposing image set soft color segments analogous color layers alpha channels commonly utilized modern image manipulation software show resulting decomposition serves effective intermediate image representation utilized performing various seemingly unrelated image manipulation tasks identify set requirements soft color segmentation methods fulfill present depth theoretical analysis prior work propose energy formulation producing compact layers homogeneous colors color refinement procedure well method automatically estimating statistical color model image results novel framework automatic high quality soft color segmentation efficient parallelizable scalable show technique superior quality compared previous methods quantitative analysis well visually extensive set examples demonstrate soft color segments easily exported familiar image manipulation software packages used produce compelling results numerous image manipulation applications without forcing user learn new tools workflows
background aims retrospective studies tbi found neuroendocrine dysfunction following traumatic brain injury adults children aims determine prevalence hypothalamo hypophyseal dysfunction children following brain injury assess relationship type injury course acute post traumatic phase patients methods body development growth pubertal development skeletal maturity evaluated patients girls brain injury rated glasgow coma scale gcs patients underwent standard endocrine tests tsh igf prl morning cortisol fsh testosterone boys estradiol girls early post traumatic period days months injury dynamic tests carried patients abnormalities clinical examination laboratory results mri performed patients results median age time injury years patients gcstanner examination confirmed combined pituitary hormone deficiency two boys another one hormonal dysfunctions diagnosed two boys precocious puberty growth hormone deficiency new endocrine dysfunction diagnosed five patients growth hormone deficiency two hypogonadotropic hypogonadism two one patient already diagnosed growth hormone deficiency central hypothyroidism well brain mri revealed empty sella two patients growth hormone deficiency patients gcs symptoms siadh early post traumatic period patients gcs frequent hormonal disorder individuals moderate trauma incidence endocrine dysfunction significantly correlated severity injury indicator development late hormonal disorder conclusion within year injury hormonal disorder found patients neuroendocrine dysfunction late consequence craniocerebral trauma children adolescents less frequent adults risk factors development gravity injury brain scan pathology possibly development siadh csws acute post traumatic phase
neurodevelopmental psychiatric disorders including autism spectrum disorder schizophrenia complex heterogeneous disorders affect large portion world population causes still poorly understood currently available treatments limited development rational therapeutics based understanding etiology pathogenesis disease imperative breakthrough technology deriving induced pluripotent stem cells ipscs reprogrammed somatic cells healthy subjects patients offers unprecedented opportunity recapitulate normal pathological development human tissue thereby opening new avenue disease modeling drug development genetically tractable disease relevant system review recent progress use human ipscs modeling neurodevelopmental psychiatric disorders developing novel therapeutic strategies discuss challenges rapidly moving field wiley periodicals inc
hilbert space tilde singular integral operator non carleman shift conjugation considered cauchy projectors sigma bar continuous functions unit circle shift operator operator complex conjugation estimates dimension kernel operator obtained
ambient intelligence ami systems contextual information time location available resources people behavior etc usually needs monitored analyzed order offer pro active context aware functionalities end users therefore contextual information conform information model commonly devised capture specific features concrete ami system hence incorporation new functionalities ami system usually involves modification associated information model may lead compatibility maintainability difficulties moreover data integration interoperability information level different ami systems limited availability shared concepts respective information models overcome problems paper presents information model adapted specific data requirements many different ami systems reused across benefits proposal validated development mobile forensic workspace mfw disaster scenarios
concern occupational health safety construction work reflected many preventive measures taken however examples systematic assessment project alternatives aimed minimizing occupational hazards rare paper proposes measure occupational safety occupational risk index ori based solely project design resulting construction process function activities carried specific occupational risks probability occurrence probable consequence proposal illustrated example two alternatives one precast constructed situ prioritized terms occupational safety certain aspects related redesign briefly addressed research based analysis applicable legislation interviews experts risk prevention ori occupational safety goes passive influence applications projects already designed active one design concept ori thus used indicator feed multicriteria decision analysis tools
objectives characterize psychotropic medication use traumatic brain injury tbi hospitalization among older adults secondary objective determine receipt indicated pharmacologic treatment anxiety post traumatic stress disorder ptsd differs following tbi design retrospective cohort setting united states participants medicare beneficiaries aged years hospitalized tbi continuous drug coverage months tbi measurements obtained monthly psychotropic medication use drug class specific drugs medicare part drug event files icd codes used define anxiety ptsd results average monthly prevalence psychotropic medication use among patients hospitalized tbi antidepressants constituted prevalence psychotropic medication use increased following tbi psychotropic medication use increased slightly tricyclic antidepressant use decreased post tbi whereas use sedating antidepressants mirtazapine trazadone increased antipsychotic use also increased post tbi beneficiaries newly diagnosed anxiety ptsd post tbi less likely receive indicated pharmacologic treatment conclusions older adults hospitalized tbi high prevalence psychotropic medication use yet less likely receive indicated pharmacological treatment newly diagnosed anxiety ptsd following tbi
attention deficit hyperactivity disorder adhd risk substance use disorders aim study investigate association adult adhd symptoms opioid use disorder life dysfunction occurring psychiatric symptoms heroin dependent patients opioid substitution treatment participated survey patients screened adult adhd symptoms using adult adhd self report scale asrs patients screened positive concurrent adult adhd symptoms status heroin dependence education level lower among patients adhd symptoms significant respect non adhd patients patients greater adhd symptoms severity less likely employed positive association observed adhd symptoms status psychiatric symptoms patients adhd symptoms status likely smokers patients methadone higher rate adhd symptoms status compared buprenorphine individuals prescribed psychoactive drugs likely adhd symptoms conclusion high rate adhd symptoms found among heroin dependent patients particularly affected severe form addiction individuals higher rates unemployment morbid mental health conditions heavy tobacco smoking additional psychopharmacological interventions targeting adhd symptoms opioid substitution public health need
background estimated number cigarette smokers world billion expected rise billion million smokers living smoking leading preventable death cause worldwide responsible almost deaths annually combination pharmacological interventions including nicotine replacement therapy bupropion varenicline behavioural support effective approach smoking cessation however even best methods high relapse rates approximately within months electronic cigarettes use battery power disperse solution usually contains propylene glycol glycerine water flavouring nicotine cigarettes become popular smoking cessation aid england however information effects cardiovascular function limited contradictory cigarettes solely nicotine based products existing research exploring effects nicotine cardio vasculature provides limited information extensive uptake urges need evidence inform general public smokers policy makers methods pragmatic group randomised assessor blinded single centre trial exploring cardiovascular physiological effects use cigarettes nicotine free nicotine inclusive assessed separately combined behavioural support smoking cessation method comparison combination nrt behavioural support primary outcome macro vascular function determined flow mediated dilatation ultrasound assessment months following participants quit date discussion participants assessed baseline days following self determined quit date intervention end months months following quite date findings expected give indication cardiovascular effects cigarettes short medium term period informing general public policy holders researchers helping define future role cigarettes smoking cessation aid
circadian clocks driven signals habitat match solar day reset phase relative local time key function circadian clocks allows individuals anticipate routine environmental conditions adjust behaviors change conditions clinical practice mood anxiety alcohol use disorders often comorbid conditions clinical data demonstrated abnormalities circadian rhythms patients mood disorders alcohol use disorders recent findings molecular genetics yielded first insight targets interest circadian clock gene variants fruitful target elucidation pathogenesis findings gained support indicate genetic variants rora cry associate depressive disorder rorb nrd bipolar disorder npas cry seasonal affective disorder winter depression concerning anxiety disorders alcohol use disorders current findings preliminary need verification explain association arntl suggestive social phobia alcohol abuse
microalgae represents promising feedstock due inherent advantages high solar energy efficiencies large lipid fractions utilization variouswaste streams including industrial flue gas study directly evaluates compares economic viability biomass production two different open cultivation platforms algal turf scrubbers open raceway ponds modular sub process models developed leveraged economic comparison systems metric harvested biomass system boundary expanded include downstream processing production renewable diesel thermochemical conversion comparison production platforms cost per gallon fuel economic results two production pathways show biomass production cost algal turf scrubber tonne per gallon fuel open raceway pond results give biomass cost tonne fuel cost per gallon sensitivity analysis show productivity culture stability critical factors economic viability multiple scenarios presented baseline results directly compared literature highlight need robust growth modelling elsevier rights reserved
clock gating effective way reduce dynamic power digital sequential circuits paper gate level activity correlation based clustering clock gating ccg technique proposed digital filters ccg technique exploits correlations flip flops determines group flip flops clock gating activity correlation matrix acmtx introduced describe correlations flip flops greedy clustering algorithm proposed find optimised clustering scheme well experiments iscas benchmarks show proposed technique reduce power consumption average top existing technique circuits large numbers flip flops proposed technique save power average
despite recent advances distributed rdf data management processing large amounts rdf data cloud still challenging spite seemingly simple data model rdf actually encodes rich complex graphs mixing instance schema level data sharding data using classical techniques partitioning graph using traditional min cut algorithms leads inefficient distributed operations high number joins paper describe diplocloud efficient scalable distributed rdf data management system cloud contrary previous approaches diplocloud runs physiological analysis instance schema information prior partitioning data paper describe architecture diplocloud main data structures well new algorithms use partition distribute data also present extensive evaluation diplocloud showing system often two orders magnitude faster state art systems standard workloads
digital hemispherical photography simple non destructive method estimating canopy biophysical parameters ecological applications validation remote sensing products determination optimum repeatable acquisition procedures well documented literature far focused evaluating levelling procedure used align camera paper standard recommendation tripod levelling necessity tested comparing hand levelled procedure results show average difference two procedures effective plant area index gap fraction valeri plot scale generally falls within variance users implementing hand levelled technique expect large reductions data acquisition time allowing many samples collected without compromising overall quality data retrieved authors published elsevier
aim study investigate prevalence subclinical ankle involvement ultrasound patients rheumatoid arthritis study conducted patients healthy sex age matched controls patients history clinical evidence ankle involvement underwent examination ankle tibio talar joint tibialis anterior tendon extensor halux extensor common tendons tibialis posterior tendon flexor common tendon flexor hallux tendon peroneous brevis longus tendons achilles tendon plantar fascia assessed following abnormalities recorded synovitis tenosynovitis bursitis enthesopathy rupture bmi das esr crp also obtained total ankles patients ankles healthy controls assessed patients showed ankle abnormalities whereas control group found abnormalities subjects frequent abnormality patients tenosynovits followed tenosynovitis synovitis tenosynovitis enthesopathy bursitis patients positive found statistically significant correlation found findings age disease duration bmi das esr crp present study provides evidence higher prevalence subclinical ankle involvement patients age gender matched healthy controls identified
urban rail transit project become one main infrastructure projects china important construction management mode bot mode used urban rail transit projects china problems bother bot mode urban rail transit project recent years applied research bot mode urban rail transit project important realistic meaning development construction infrastructure projects relevant theoretical foundations given first paper according main problems financing construction operation bot mode urban rail transit project related countermeasures put forward absorbing private capital foreign investment strictly controlling cost construction means changing original management mode exploring external benefit urban rail transit project
background ulcerative colitis involves colonic mucosa yet nearly patients undergo total proctocolectomy ileal pouch anal anastomosis develop like inflammation ileal pouch pouchitis contrast patients familial adenomatous polyposis fap ileal pouch anal anastomosis develop pouchitis far less frequently hypothesized pathogenic events associated development recapitulated colonic metaplastic transcriptomic reprogramming pouch methods prospectively sampled pouch prepouch ileum mucosal biopsies patients ileal pouch anal anastomosis months pouch continuity mucosal samples also obtained patients fap transcriptional profiles fap pouch prepouch ileum investigated via rna sequencing compared data previously published microarray study results unlike patients fap subjects exhibited large set differentially expressed genes pouch prepouch ileum early months pouch functionalization functional pathway analysis differentially expressed genes pouch revealed enhanced state immune inflammatory response extracellular matrix remodeling moreover differentially expressed genes mapped published inflammatory bowel diseases microarray data sets displayed directional changes consistent active crohn disease conclusions pouch well histologic inflammation already displays systems level gain colon associated genes loss ileumassociated genes patients exhibit unique transcriptomic response ileal pouch creation observed well disease may part explain susceptibility development pouchitis
new vision based system designed identification chatter vibration chatter vibration major obstacle cnc machining causes bad surface finishes increases tooling damage costs research proposes use machine vision detection chatter vibration frequencies high speed milling operations vision system utilizes digital image processing texture analysis determine frequencies chatter marks surface machined workpiece developed system provides solution machinists ease without expensive measuring equipment vision system verified compared chatter detection methods identifying creating tests based dynamics machine tool
asthma heterogeneous group conditions typically begin early life result recurrent reversible bronchial obstruction role played epigenetic mechanisms pathogenesis childhood asthma understood part discuss asthma epigenetics within developmental perspective based recent demonstration epigenetic trajectory childhood asthma begins birth next discuss trajectory may affected prenatal environmental exposures finally examine vitro studies model impact asthma associated exposures epigenome studies specifically surveyed human dna methylation involved genome wide component combination results broaden understanding asthma pathogenesis role methylome plays process
electronic storage patient related data replace paper based patient records near future steps medical practice even achieved without electronic data processing systems conventional paper based electronic based records advantages disadvantages taken consideration advantages electronic based records good availability data structured storage data scientific analysis long term data possible data exchange colleagues context teleconsultation systems problems solved field data security initial high investment costs time consumption learning use system well incompatibility existing systems
purpose review purpose review provide update osteoporosis epidemiology focus fractures fractures important clinical consequence osteoporosis studies published past months identified reviewed finally clinical impact new findings discussed recent findings important research include analyses screening rescreening younger women older men risk factors hip fractures older men obesity weight loss gain risk fracture several dietary factors including adherence mediterranean diet diet rich protein fruits vegetables maintenance physical function increasing age represent modifiable nonpharmacologic risk factors improve bone health sarcopenia may important role fracture men women important biomarkers fracture include low hydroxyvitamin hemoglobin summary updated literature fracture epidemiology identified important risk factors fracture
article focuses development intercultural awareness teaching professional russian formation intercultural competence represents one key elements professional teaching specialists intercultural competence comprises skills vital verbal nonverbal communication foreign language native speakers requiring perception management various socially culturally rooted language phenomena consideration cultural peculiarities pertaining country language studied need develop competence poses new challenges teachers requiring develop new perception learning goals respective article dwells didactic aspects learners adaptation peculiarities foreign culture well teaching effective communication achieve professional goals considering intercultural factor various didactic techniques therein analysed namely linguo conceptual approach teaching foreign language formation discourse frames necessary professional everyday communication exercises texts containing culturological information tailor made system exercises targeted eliminating possible communication failures inflicted cultural discrepancies purpose achieve level competence sufficient adequate correct implementation communication goals analysed situations everyday business communication published elsevier ltd
use cement based composites strain sensors studied different researchers effect cross talk strain perpendicular electric current cement based composite important issue using cement based material strain sensor study steel fiber reinforced cement matrix composite tested two different compression tests compressive strain electric current parallel perpendicular cross talk compression test electric current compressive strain perpendicular conducted first time study also split tensile tests tensile strain electric current parallel perpendicular applied first time study cross gage factors higher gage factors explained mechanisms variations electron transfer cross sections strong linear relationships perpendicular compressive strain electrical resistance change perpendicular tensile strain electrical resistance change obtained strong linear relationships used decompose effects cross talk cement based sensor applications elsevier ltd rights reserved
cryptococcosis potentially lethal disease humans animals caused cryptococcus neoformans cryptococcus gattii distinction two species based phenotypic genotypic characteristics recently proposed neoformans divided two species gattii five species based phylogenetic analysis isolates proposal adds knowledge genetic diversity population structure cryptococcosis agents published genotypes strains already revealed genetic diversity encompassed seven species naming every clade separate species juncture lead continuing nomenclatural instability absence biological differences clades consensus dna sequence alone delineate species recommend using cryptococcus neoformans species complex gattii species complex practical intermediate step rather creating species strategy recognizes genetic diversity without creating confusion
environmental enrichment strategy improve animal welfare providing brain plasticity changes cellular molecular behavioral levels order test long term effects enriched housing importance testosterone levels expression behavioral plasticity categories assessed adult swiss mice subdivided prepubertal castrated non castrated groups maintained seven months three non sibling mates enrichment consisted introducing insets gnawing climbing hiding tests spontaneous exploration barrier territoriality intruder hierarchical organization group applied measurements body weight relative weight key organs done end experiment mice kept enriched cages either castrated non castrated showed spontaneous exploration raised standard cages non castrated mice housed structured cages lower frequency attack resident intruder test non castrated standard caged mice indicating decrease territoriality first group independent housing conditions castrated mice showed reduction offensive defensive social contacts well low frequency attack agonistic tests well known importance testes ensure expression aggressive social contact behaviors therefore challenged enrichment condition behavioral repertoire home cage performance group test organometric measurements significantly different groups kept enriched non enriched cages results suggest experience enriched environment increase aggressiveness routine home cage negatively influence physiological parameters independently testosterone level elsevier rights reserved
objective aims study investigate prevalence unadjusted adjusted odds month generalized anxiety disorder gad among adults migraine comparison without migraine debilitating pain limitations instrumental activities daily living iadls mediators migraine gad association factors associated past year gad among adults migraine methods secondary data analysis nationally representative canadian community health survey mental health cchs population based survey community dwellers response rate first subsample included without migraine second subsample restricted migraine gad based cidi scale results fully migraines past year gad comparison without migraine socio demographically adjusted odds past year gad two half times higher among migraine without path analysis indicated debilitating pain limitations iadls mediators relationship migraine gad sample restricted migraineurs factors associated higher odds month gad included university degree low income without confidant male conclusions generalized anxiety disorder robustly associated migraine targeted outreach interventions warranted
idiopathic pulmonary fibrosis ipf progressive lung disease characterized chronic inflammation fibroblast proliferation extracellular matrix deposition however molecular cellular mechanisms underlying pathogenesis pulmonary fibrosis remain fully elucidated contribution phosphoinositide kinase pik protein kinase akt pathway fibrotic processes remains investigated aim present study investigate role pik akt pathway pulmonary fibrosis rat model pulmonary fibrosis induced intratracheal administration bleomycin blm specific pik akt inhibitor used assess role pik akt pathway fibrogenesis inflammatory fibrotic alterations lung tissues evaluated using histological staining hydroxyproline assay addition concentration cytokines bronchoalveolar lavage fluid expression akt phosphorylated akt epithelial cadherin smooth muscle actin vimentin lung tissues data demonstrated increase expression levels akt involved progression pulmonary fibrosis contributed fibrogenesis administration akt inhibitor significantly attenuated inflammation fibrosis accompanied reversal lung fibrosis associated epithelial mesenchymal transition taken together observations suggest pik akt pathway serves central role pathophysiology lung fibrosis promising therapeutic target
paper details modeling support design air core permanent magnet based energy harvest system use within pipe mobile water quality sensor challenge presented system electrical mechanical dynamics device strongly coupled recently rigorous electrical mechanical model established address challenge order determine expected energy harvest given geometric material parameters electrical mechanical inputs initial focus herein development parameter measurement techniques purposes model validation subsequently based upon hardware results alternative friction model derived utilized explore effect friction expected energy harvest
dual rate sampled hammerstein controlled autoregressive moving average carma system paper uses polynomial transformation technology obtain dual rate bilinear identification model suitable available dual rate sampled data uses maximum likelihood principle construct unified parameter vector parameters information vector formed derivative noise variable unified parameter vector directly identifies parameters linear block nonlinear block dual rate hammerstein carma system unified parameter vector contains minimum number unknown parameters proposed maximum likelihood estimation algorithm higher computational efficiency parameterization model based least squares algorithm
development performance characterization new differential pressure based flow meter human breath measurements presented article device called confined pitot tube comprised pipe elliptically shaped expansion cavity located pipe center elliptical disk inside expansion cavity elliptical disk named pitot tube exchangeable different diameters smaller diameter elliptical cavity gap disk cavity allows flow human breath pass disk causes obstruction flow inside pipe elliptical cavity provides expansion flow circulate around disk decreasing overall flow resistance characterize new sensor flow experimentally theoretically using comsol multiphysics software laminar turbulent models also validate sensor using inhalation exhalation tests reference method american institute chemical engineers aiche
urban parks easily available settings seniors engage daily physical activity type low cost physical activity walking bring seniors multiple health benefits among park facilities park pathways significantly related physical activity present study examined links specific park pathway design characteristics senior walking within urban park observations interviews study conducted two neighborhood parks beijing china site observations utilized collect data senior walking behavior dependent variable pathway design characteristics independent variable calculated average number observed seniors observations represent usage pathway segment interviews conducted explore pathway design characteristics preferred disliked senior users anova analyses correlation analyses revealed seniors prefer pathways soft even pavement plastic track bricks benches flowers light fixtures also seniors attracted pathways long meters wide without connection activity zones addition results suggest pathway design characteristics along water body shade providing lateral visibility visual connection water without visual connection landmarks may also encourage senior walking providing park pathways preferred seniors designers create park environments supportive senior walking ultimately contribute improving senior health life quality elsevier gmbh rights reserved
current study aimed devise eco friendly safe cost effective strategies enhanced degradation low high density polyethylene ldpe hdpe using newly formulated thermophilic microbial consortia cow dung assess biodegradation end products plastic degrading bacteria cow dung samples gathered highly plastic acclimated environments enriched standard protocols degradation ability comprehended zone clearance method percentage degradation monitored weight reduction process best isolates characterized standard microbiological molecular biology protocols best isolates employed form several combinations microbial consortia degradation end products analyzed stability ribosomal dna rdna predicted bioinformatics approach study identified degradation ldpe strips pellets hdpe strips pellets respectively period days degrees formulated consortia degradation efficiency found better comparison formulations end product analysis fourier transform infrared scanning electron microscopy energy dispersive spectroscopy nuclear magnetic resonance showed major structural changes formation bacterial biofilm plastic surfaces novel isolates designated bacillus vallismortis dsce psuedomonas protegens dsce stenotrophomonas dsce paenibacillus dsce rdna sequencing suggested good gene stability minimum gibb free energy therefore study imparts substantial information regarding utilization thermophilic microbial consortia cow dung rapid polyethylene removal
hypersensitivity reactions foods diverse highly variable manifestations cutaneous reactions acute urticaria angioedema among common manifestations food allergy however cutaneous manifestations food allergy encompass ige mediated processes include atopic dermatitis contact dermatitis even dermatitis herpetiformis cutaneous manifestations provide opportunity better understand diversity adverse immunologic responses food interconnected pathways produce
paper presents results engine air path infinity state feedback switched linear controller main advantage approach controller gains calculated offline robust specifications allowing fast calculation cost effective calculation resources air path system dynamics governed saint venant equations difficult handle control synthesis due nonlinear properties states control inputs coupling nonlinear functions employ advanced control techniques switched linear state space representation proposed model simplified considering slow dynamics quite constant proposed approach provides robust state feedback control toward perturbations model error unmodeled dynamics considering disturbances unknown inputs
healthy lifestyles integral preventing treating common cardiovascular metabolic diseases aim studywas observe smoking habits alcohol intake physical activity body mass index year period population based cohort particularly focusing participants hypertension type diabetes mellitus included participants first second follow ups swiss cohort study air pollution lung heart disease adults sapaldia information collected via health questionnaire height weight measured healthy lifestyle score one point attributed per criterion non smoking lowrisk alcohol consumption bmi regular physical activity overall smokers risk alcohol consumption physically inactive overweight obese hypertension diabetes lower mean healthy lifestyle scores without disease women incident hypertension lower odds improving healthy lifestyle score time period compared without disease contrast women incident diabetes higher odds lifestyle score improvement men neither hypertension diabetes associated change lifestyle score findings suggest irrespective disease status preventative attention needed particularly regards physical activity bodyweight needs could bemet population based interventions necessary suitable option preventing treating non communicable disease epidemic currently faces countries worldwide elsevier inc rights reserved
computer aided diagnosis systems based brain imaging powerful tool assist diagnosis alzheimer disease goal automatic recognizing neurodegenerative patterns characterize disease regard determining regions related disease results crucial select discriminative voxels optimize number features used learning algorithm paper propose method based robust principal component analysis robust pca algorithm allows automatically compute regions interest rois training set images rank according diagnostic relevance robust pca used compute sparse error matrix turn employed determine brain areas related alzheimer disease areas used mask select weight discriminative voxels construct classification model describe method fuse features computed different image modalities based weights assigned individual support vector classifiers training process method presented applied multimodal image containing functional fdg pet structural magnetic resonance data experiments conducted using control subjects patients show effectiveness proposed approach exploratory analysis time classification experiments using features computed proposed method assessed cross validation showed accuracy values auc area curve thus proposal seems effective technique reveal rois differential diagnosis applications combine multimodal image data outperforming classification methods including voxelas features vaf baseline elsevier rights reserved
background etiology strabismus genetic component study aimed localize candidate causative gene mutant chinese family strabismus describe underlying etiology material methods genomic dna extracted affected individual parents chinese pedigree strabismus resulting exomes sequenced whole exome sequencing variant calling filtering candidate causative gene mutations selected rarity predicted damaging effect complied model recessive disease transmission results examined chinese strabismus pedigree parents unaffected offspring affected wholeexome sequencing bioinformatics filtering identified variants including abelson helper integration site ahi gene nebulin neb gene variant ahi gene altered amino acid damaging effect encoded protein predicted polyphen moreover change located conserved domain ahi biallelic pathogenic variant ahi gene cause joubert syndrome related disorders oculomotor apraxia characteristics additionally mutation found nebulin neb gene therefore concluded ahi neb potential causal variants strabismus pedigree conclusions detected ahi homozygous mutation affected individual whole exome sequencing powerful way identify causally relevant genes improving understanding disorder
tensor analysis reached celebrity status areas machine learning computer vision artificial intelligence completing recovering tensor important problem tensor analysis involves recovering tensor either subset entries whole entries contaminated noise classical tensor completion recovery methods based mainly norm gaussian distribution noise models sensitive noise large magnitude norm laplacian distribution noise based methods robust noise large magnitude deal dense noise effectively paper present novel cauchy tensor decomposition method simultaneously recovering completing low rank tensor missing data complex noise utilize cauchy distribution model noise derive objective function cauchy tensor decomposition maximum likelihood estimation mle framework developed robust tensor decomposition framework used first order optimization approaches optimize objective function extensive numerical experiments conducted show method able successfully recover complete tensors large dense noise missing data demonstrate usefulness cauchy tensor decomposition three real world applications image inpainting traffic data process foreground background separation experimental results show method applicable wide range problems
performance design methodology multiplexer mux optical reconfigurable logic circuit using gaas algaas based optical micro ring resonator omrr presented current paper proposed design reconfigurable logic circuit capable perform eight different logic operations performances logic circuits theoretically analyzed using domain modeling numerical simulation results confirming method explained present paper proposed circuit simple compact efficient minimum number omrr low operating power high operating speed high factor different figure merits purposed model calculated simulation results
background aimsofosbuvir sof first directly acting antiviral made available chronic hepatitis chc india describe real life experience using sof ribavirin rbv without pegylated interferon peg ifn predominant genotype patients chc methods total patients men mean age years chc treated dual therapy sof rbv weeks triple therapy peg ifn sof rbv weeks included prospectively patients infection decompensated liver disease post organ transplantation excluded data analysed preference treatment regimen end treatment response etr sustained virological response weeks side effects results genotype predominant genotype followed genotype genotype forty eight patients cirrhosis lsmkpa treatment experienced peg ifn rbv total patients received dual therapy received triple therapy resentment receive injections inaccessibility facility fear injection side effects financial constraints reasons refuse triple therapy patients triple therapy group two patients dual therapy group attained etr achieved etr achieved sustained virological response weeks groups anemia three patients two triple one dual therapy major side effects conclusions patients chc prefer oral treatment directly acting antivirals oral interferon based regimens achieve high response rate
methadone cornerstone therapy opioid addiction public health strategy hiv aids hepatitis reduction methadone also used acute chronic pain use chronic pain grown adverse events constitutive acquired drug interactions inter intraindividual variability methadone pharmacokinetics pharmacodynamics confounds reliable clinical use identification enzymes transporters responsible methadone disposition long sought ideal initial vitro studies identified cypa metabolizing methadone subsequently extrapolation cypa long assumed responsible clinical methadone disposition however cypb also major catalyst methadone metabolism vitro unequivocally established cypb cypa principal determinant methadone metabolism clearance elimination plasma concentrations humans methadone disposition susceptible inductive inhibitory drug interactions cypb genetics also influences methadone metabolism clearance diminished cypb carriers increased cypb carriers cypb genetics explain part interindividual variability methadone metabolism clearance thus constitutive variability due cypb genetics cypb mediated drug interactions alter methadone disposition clinical effect drug safety methadone substrate major influx efflux transporters
whereas link working memory memory distortions demonstrated influence emotional false memories unclear two experiments verbal task false memory paradigm negative positive neutral events employed experiment investigated individual differences verbal found interaction valence predicted false recognition negative positive material protecting high individuals false remembering beneficial effect negative material disappeared low participants experiment lowered capacity half participants double task request led overall increase false memories furthermore consistent experiment increase negative false memories larger neutral positive ones concluded plays critical role determining false memory production specifically influencing processing negative material
interest important role ethical leaders play organizations expanded recent years several high profile corporate ethical breakdowns increased responsibility placed upon corporate leaders result present study introduce new outcome ethical leadership group ethical voice theorized tested two mediating mechanisms linking ethical leadership group ethical voice using two field studies one experimental study found support assertion ethical leadership positively associated group ethical voice also found support hypothesized mediating mechanisms ethical culture group ethical voice efficacy linking ethical leadership group ethical voiceexcept indirect effect upper level ethical leadership group ethical voice via group ethical voice efficacy found group ethical voice positively influenced ethical performance significant sales groups marginally significant customer service groups contributions ethical leadership voice literature discussed along limitations current study directions future research
alzheimer disease serious age related neurodegenerative disorder accompanied significant memory impairments world recently micrornas mirnas reported invlolved pathophysiology previous studies shown mirna mir implicated pathogenesis via suppressing expression brain derived neurotrophic factor bdnf brain examined mir mir expression hippocampus cortex abeta precursor protein app presenilin transgenic mice treated donepezil drug approved treating clinic found expression mir significantly regulated hippocampus cortex app mice donepezil administration significantly reversed dysfunction addition enhancing mir level usage agomir significantly attenuated anti dementia effects donepezil app mice together results suggested mir involved anti dementia effects donepezil could novel pharmacological target treating
propose use negative dielectrophoresis dep spectroscopy technique improve detection limit rare analytes biological samples observe significant dependence negative dep force functionalized polystyrene beads edges interdigitated electrodes respect frequency electric field measured velocity repulsion conjugation avidin biotin functionalized polystyrene beads automated software real time image processing monitors rayleigh scattering beads significant difference velocity beads observed presence little molecules avidin per biotin functionalized bead technology applied detection quantification rare analytes useful diagnosis treatment diseases cancer myocardial infarction use polystyrene beads functionalized antibodies target biomarkers society photo optical instrumentation engineers spie
concerns environmental impacts urban mobility led development alternative solutions battery electric vehicles bev highly applicable certain sectors namely urban logistics since bev powertrain characteristics extremely suited urban driving context research work evaluates adequacy bev urban logistics lisbon based real world application vehicle second second data collected regular operation internal combustion engine vehicle icev bev months respectively results demonstrate bev allows maintaining operation patterns regarding number kilometers travelled per day recharging time vehicle dynamics average speed icev bev comparing energy impacts shifting electric mobility bev allows reducing vehicle usage energy consumption considering energy production stage logistics operations performance affected vehicle technology shift since operational requirements service maintained issues electric autonomy recharging periods observed confirming suitability vehicle technology specific urban logistics applications elsevier ltd rights reserved
giant invasive sacral schwannomas rare tumors surgical excision standard treatment total resection performed feasible advances three dimensional imaging technology facilitated treatment designs complex surgical procedures aim evaluate virtual surgical planning computer aided design cad manufacturing printing technology customized osteotomy guiding device giant invasive sacral schwannoma resection digital model sacrum including giant invasive sacral schwannoma rendered patient computer tomography images surgeon chose excision margins tumor based virtual surgical planning customized guiding tool osteotomy designed manufactured using cad printing used guiding block successfully excise giant sacral schwannoma using posterior approach achieve gross total resection augmented spinal instrumentation used prevent iatrogenic spinal instability clinical symptoms resolved dramatically operation spinal instability occurred follow assistance image based customized osteotomy guiding device achieved goals tumor resection bone preservation giant sacral schwannoma resection thorough surgical planning technology applied complex surgical procedures easily reliably
wia industrial wireless networking protocol standard used process automation one mechanism based wia multi channel mac proposed solve industry wireless sensing questions network channel disturbance medium turning conflict mechanism mainly includes multi channel mac mechanism design proposal channel assignment algorithm design wia
paper presents buffered edge reconfigurable cell array berca architecture applications distinctive feature architecture dual mode operations reconfigurable cell array operate either blocking mode non blocking mode renders amenable efficient dataflow computation small buffer attached link berca enable synchronized computation style systolic array approach devised map signal flow graph onto berca array unlike previous systolic array mapping methods approach able map irregular graphs regular graphs specified simple recurrence equations opens wide range applications berca
integrated urban drainage modelling combines different aspects urban water system common framework increasing pressures changing climate urban growth economic constraints need wider spread integration necessary interest sustainable future greater complexity results greater computational burden modelling packages likewise need flexible enough allow incorporation new algorithms advancements modern information technology parallel implementation modelling toolkit mandatory still leaving users flexibility extensions design implementation integrated modelling framework citydrain shows possible write research code high performance extensible many research projects three use case scenarios presented showcase application citydrain performance advantage parallelization times compared predecessor scalability framework also demonstrated elsevier ltd rights reserved
regard mental illness brain donation essential biological investigation central pathology nevertheless little known thoughts people mental disorders tissue donation research objective understand attitudes opinions people treated bipolar disorder relatives regarding donation general particularly donation research qualitative study used depth interviews determine thoughts participants regarding tissue donation research theoretical sampling used recruitment method grounded theory used framework content analyses interviews semi structured interview guide applied topics donation general donation research mental health body organs opinion regarding donation feelings aroused topic although participants aware organ donation transplant surprised tissue could donated research nevertheless understood concept usually favor idea although participants demonstrated general lack knowledge donation research willing learn viewed good thing altruistic reasons often cited motive donation speculate bridging knowledge gap may fundamental step towards ethical postmortem tissue donation process
construction sector country world always plays important role economy keeps task forming building developing infrastructure poor infrastructure create modern society specific characteristics construction industry construction progress projects face risks difficulties project teams vietnam facing unprecedented changes technology products investment resources ect therefore measurement factors affecting success project vietnam aimed improving efficiency project based relevant previous studies comments experts construction industry rough questionnaire formed sent six individuals extensive experience field construction management testing interview analysising evaluating eliminating superfluous elements adding elements draft questionnaire finally research team completed questionnaire established four criteria evaluating success project included cost time technical completion customer satisfaction criteria measured four groups factors affect success project namely external environment ability construction project manager capacity project members way organize projects questionnaire requires individual participating survey give opinions impact factors success project based seven level likert scale less stable high stability corresponding score
vulnerability microcontroller system high altitude electromagnetic pulse hemp taken illustration demonstrate assessment methodology based bayesian networks complete procedure performed two steps qualitative quantitative first step focuses analysis three classes properties electromagnetic environment system function structure interactions primary model built end first step second step investigates nodes branches one one implemented two stages data acquisition data fusion susceptibilities devises examined pulsed current injection responses transmission lines hemp computed using field line coupling model comparing probability density functions electromagnetic stresses strengths produces failure probabilities interface components two step analysis critical elements coupling paths identified highlighted neglecting unimportant factors many nodes branches deleted thus complexity assessment reduced assigning probability values simplified model system failure probability calculated characterizes system vulnerability hemp environment illustration validates rationality flexibility assessment methodology
pollen analyses spider web samples collected recently planted tectona grandis grandis teak dominated tropical deciduous forest bhulsidih village korba district chhattisgarh central india shed light relationship extant vegetation pollen rain study revealed dominance pollen herbs trees whereas shrubs fern spores algal remains meagre among tree taxa sapotaceae syzygium holoptelea lannea coromandelica shorea robusta grewia dominating moderate low intermittent presence madhuca indica terminalia mitragyna schleichera anacardiaceae diospyros emblica officinalis flacourtia however rest forest constituents either represented despite presence floristics could attributed low pollen productivity owing entomophily well poor pollen preservation pattern hand ground vegetation represented high frequency grasses poaceae along tubuliflorae chenopodiaceae amaranthaceae cerealia however artemisia xanthium malvaceae caryophyllaceae justicia moderate lower values ferns occur abundantly along adjoining stream banks marked sporadic retrieval trilete spores could ascribed prevailing damp condition around sampling provenance study addition understanding pollen vegetation relationship could also helpful aerobiological study especially assessing allergenicity various pollen grains spores area investigation causing bronchial asthma hay fever allergic rhinitis pollinosis naso bronchial allergy respiratory disorders along conjunctivitis contact dermatitis eczema food allergies health disorders
rapid growth residential broadband connections internet enabled home devices driven success many useful applications video streaming remote healthcare however poorly managed routers connected devices home vulnerable persistent threats exploitations cyber attackers across internet continuously identify compromise control devices part botnets launching click fraud denial service attacks spam campaigns growing threats broad damages made imperative understand characterize filter reduce exploit traffic towards millions home routers billions connected devices home paper presents bloom filter based analytics framework capture persistent threats towards home routers identify correlated attacks towards distributed home networks experimental results based network traffic collected real homes months revealed number interesting findings persistent correlated threats towards home networks calls improved security management home networks best knowledge paper first effort characterize cyber threats towards home networks propose simple yet effective approach identify persistent aggressive attacks towards home networks copyright john wiley sons ltd
objective majority patients advanced multiple sclerosis need symptomatic treatment many related symptoms may recognized thus treated conducted study estimate prevalence inadequate symptomatic treatment patients advanced methods patients advanced admitted specialist rehabilitation clinic included study severity assessed using expanded disability status scale edss information collected included age onset initial course time sustained disability pharmacological treatment degree spasticity pain bladder dysfunction unmet needs symptomatic treatment results total assessed demographic clinical characteristics patients mean age years median edss proportion inadequate symptom treatment regarding spasticity pain bladder dysfunction discussion study showed large proportion patients advanced lack symptomatic treatment patients probably underuse neurological specialist services better symptomatic treatment could contribute improving quality life people
question terrorism becoming principal problem influences social safety terrorist acts aimed frightening people destabilisation normal functioning state terrorists trying achieve goal bombing civilians public utility facilities including transport system facilities one elements transport system infrastructure consisting roads railways bridge facilities last element encompasses example bridges viaducts flyovers culverts taking account fact bridge facilities extremely sensitive terrorist attacks authors article decided focus study work presents original method damage risk assessment engineering facilities aspect potential terrorist attacks method based two selected multi criteria optimisation methods subject analyses four selected bridge facilities results conducted research analyses risk assessments selected bridges advantage presented solution possibility justify adopted hierarchy decision variants using proposed method one obtain specific numerical values used analyses conducted wider scale build hierarchized database facilities prone terrorist attacks
induced polarization method one common methods electrical prospecting geophysical paper analyses research application embedded technology induced polarization instrument design multifunctional transceiver instrument paper realize hardware part induced polarization instrument regarding arm processor hardware core combination current intelligent power module ipm induced polarization analog signal processing digit delta sigma high precision aid conversion chip etc transplant embedded operation system uclinux embedded arm processor formulate drive program matches hardware circuit application program fulfils various functions including data acquisition data processing display data storage transmission required induced polarization instrument uclinux system management
nucleic acid amplification methods facilitate rapid sensitive detection clinically relevant fungal pathogens employed using variety patient specimens however contamination various exogenous sources constitutes serious threat validity amplification based fungal assays chapter common origins fungal contaminants compromise molecular fungal testing described measures preventing contamination proposed detailed guidelines sample handling reagent selection contamination screening decontamination procedures provided
using cross level design relying contingency approach understanding empowering leadership investigate mediating role individual level psychological empowerment cross level relationship team directed empowering leadership two complementary forms individual level citizenship affiliative organizational citizenship behavior taking charge also investigate moderating role organizational support climate relationship empowering leader behavior two forms citizenship using data collected work teams one large organization china addition support mediating role psychological empowerment found double edged moderating effect organizational support climate affiliative organizational citizenship behavior consistent reciprocation perspectives posited social exchange theory results showed highest levels occurred empowering leadership behavior organizational support climate high contrast taking charge consistent control theory results showed highest levels occurred empowering leadership behavior high organizational support climate low findings highlight counterintuitive notion organizational support climate may always uniformly positive effects also reinforce importance including individual work context factors attempting understand cross level empowering leadership effects
experimental saturated solubilities glycine alanine valine serine aqueous mixtures naf solutions measured using analytical formol titrimetry method subsequently standard transfer gibbs free energy enthalpy cavity formation gibbs free energy cavity formation gibbs free energy dipole dipole interaction computed chemical contribution standard transfer gibbs free energies experimental amino acids obtained subtracting cavity effects dipole dipole interaction effects total standard transfer gibbs free energy delta stability studied amino acids aqueous naf terms thermodynamic parameters discussed compared
paper presents new measurement based control design method cancer chemotherapy cancer chemotherapy aims basically simultaneously eradicating significantly reducing number cancer cells maintaining tolerable levels drug concentration toxicity achieve aim drugs often injected patient body according drug schedule specifying drug dose delivery time several strategies planning cancer chemotherapy developed literature evolutionary algorithms applied find optimal drug schedules cancer treatment constraints key treatment parameters drug concentration toxic side effects methods amount drug doses delivered body time treatment depend current drug concentration toxicity level number cancer cells successful design chemotherapy drug scheduling requires availability accurate mathematical model perfectly predicts number cancerous cells describes effects treatment several models either complex simple structures available literature complex structure models proposed deeply understand interactions cancer normal cells affect performance cancer chemotherapy nevertheless complex models based high order set differential equations difficult solve simple structure models often obtained basis simplifying assumptions viewed approximation cancer system hence designing chemotherapy drug schedules basis simplified models may result unsuccessful cancer treatment unlike conventional control strategies cancer chemotherapy attempt paper address problem designing control system cancer treatment using set frequency domain data hence two degree freedom pid proportional integral derivative control scheme proposed control cancer growth pid controllers designed simultaneously provide optimal amount drug doses delivered patient body according current drug concentration toxicity level maintain drug concentration toxicity levels within pre specified ranges proposed cancer control technique validated first simulation example another example control biological systems also presented show feasibility proposed method simulation results obtained demonstrated capability proposed control scheme address cancer chemotherapy problems elsevier inc rights reserved
soliton control management using generalized external potentials inhomogeneous fiber design high speed optical devices ultrahigh capacity transmission systems investigated based solving variable coefficient generalized nonautonomous nonlinear schrodinger equation help symbolic computation construct lax pair gnls equation means akns method two soliton solutions obtained virtue darboux transformation symbolic computation manipulate control parameters external potentials investigate propagation behaviors nonautonomous solitons moreover main evolution features obtained two soliton solutions exposed interesting figures computer simulation especially analyze influence external potentials periodic exponential parabolic potential soliton propagation finally soliton propagation absence vanishing external potential also discussed obtained results confirmed external potentials strong influence soliton dynamics results might provide new method achieve soliton pulse compression passing potential barrier well influence external potentials elsevier inc rights reserved
advent technology wireless sensor networks used gather information monitor data inaccessible remote areas wired network feasible due limited power back sensor network deployed wider scale processing recommended within network reduce communication overhead energy consumption low power analog processing circuits integrated within sensor nodes suitable task paper reviews analog circuitries processing data improve energy efficiency addition low power networking protocols security solutions
proximity detection systems actively marketed underground mining section way provide enhanced information operators large underground machinery date many systems lacking reliability validity ratings researchers would like see due may interact predictable way always improve operator awareness fact burgess limerick noted many fatalities occurred underground machinery operator aware location victim victim work recreates one accidents review computer simulation environment models video based proximity detection system evaluates capacity system improve operator line sight results demonstrate small window time operator may able see victim location even hypothetical camera system installed work points importance mine design machine design respect improving safety worker well downfalls existing proximity detection systems rely video feeds mounted machinery elsevier ltd rights reserved
steroids perform significant functions prostatic development growth interferences equilibrium may predispose gland development diseases life embryonic neonatal exposure xenoestrogens many endocrine disrupting potential related induction disturbances reproductive system organs thus study aimed analyse morphological immunocytochemical aspects prostate male female adult gerbils either exposed ethinylestradiol prenatal phase pregnant females received gavage group exposed testosterone postnatal period group serological analysis revealed rise estradiol levels adult males females group higher incidence prostatic intraepithelial neoplasia pin observed male female prostate treated groups besides increase collagen reticular fibres immunocytochemistry showed increase prostatic epithelial cells immunoreactive presence smooth muscle layer evidenced alpha actin injured regions way absent prostatic epithelial buds pieces evidence suggest alterations verified prostate adulthood sexes may due high oestrogen levels either males females group showed normalized estradiol levels although prostatic lesions could observed prostatic gland male gerbils affected female prostate study showed exposure critical period development disrupts prostate sexes terms prostatic lesions
eating disorders associated range abnormalities eating behavior individuals consume large amounts non caloric artificial sweeteners suggesting abnormalities appetitive responding current study aimed quantify hedonic motivating effects artificial sweetener individuals without eating disorder two laboratory studies conducted hedonic preference estimated using number artificial sweetener packets added unsweetened cherry flavored kool aid study motivation obtain sweetener assessed progressive ratio work task study ninety three participants anorexia nervosa restricting type binge purge type bulimia nervosa normal controls completed study significant difference hedonic preference found among participant groups work completed task ranged key board presses group significantly higher breakpoint performed significantly work sweetener compared groups among participants preferred number equal packets significantly correlated breakpoint total work increased amount work sweetener among individuals supports enhanced reward value sweet taste population suggests characteristic food avoidance accounted decreased reward value taste related stimuli study also supports novel application ratio task quantify motivating effect sweet taste among individuals eating disorder elsevier ltd rights reserved
essential thrombocythemia polycythemia vera philadelphia chromosome negative chronic myeloproliferative neoplasms mpns characterized jak mutation found patients approximate patients assessment jak allele burden highly sensitive quantitative pcr qpcr assay appears useful tool monitoring minimal residual disease mrd evaluating treatment efficacy report expands substantiates existing data showing ifn alpha highly potent immunomodulating agent capable inducing mrd low burden jak major molecular response mmr complete hematological remission chr complete histomorphological normalization bone marrow sub set patients long term treatment years furthermore long lasting hematological molecular histomorphological remissions sustained discontinuation ifn alpha approximate years
security terms networks turn significant organizations military personal computer user since various kinds threats data sending sender side internet till reaches receiver focus ssl technique used give client server authentication data confidentiality data integrity transform data unintelligible form data sending text text form encrypting data save attacks like eavesdropping interception communication unauthorized person either listen add malicious information data lead catastrophic results technique secure data transmission useful securing integrity data sent unmanned aerial vehicles military application commercially used electricity meter since mentioned devices uses microcontroller send data internet hence data always going susceptible mentioned threats important ensure fall wrong hands objective microcontroller sends data remote location authenticity confidentiality integrity first send meaningful text already stored controller stmg eval board data sent server encrypted packets sending remote server ethernet receiver end data received decrypted get original captured data
using chemical vapor deposition methods prepare carbon nanotubes growing situ carbon felt graphene polyaniline applied carbon felt modifying carbon nanotubes microbial fuel cell constructed graphene polyaniline modified carbon nanotubes anode graphite cathode glucose solution substrate effects electrodes substrate concentration temperature properties microbial fuel cell studied degrees using glucose solution external resistance omega optimum output voltage removal rate chemical oxygen demand obtained microbial fuel cell prepared nanomaterials stable reusable
visual animal biometrics emerging research discipline computer vision pattern recognition cognitive science promising research field encourages new development quantified algorithms methodologies representing detection visible features phenotypic appearances species individuals recognition morphological animal biometric characteristics furthermore also assists study animal trajectory behaviours analysis species currently real world applications visual animal biometric systems gaining proliferation due variety applications use enhancement quantity quality collection extensive ecological data processing however advance visual animal biometrics require integration methodologies among scientific disciplines involved valuable efforts worthwhile due enormous perspective approach rests formal abstraction phenomics build well developed interfaces different organisational levels life study provides comprehensive survey visual animal biometric systems recognition approaches various species individual animal based morphological image pattern biometric characteristics comprehensive review paper encourages multidisciplinary researchers scientists biologists different research communities design better platforms development efficient algorithms learning models solve massive data processing classification identification different species related problems
enteropathogenic escherichia coli epec one diarrheagenic coli pathotypes among important food borne pathogens infecting children worldwide inhibition serotonin transporter sert regulates extracellular availability serotonin implicated previously epec associated diarrhea epec shown inhibit sert via activation protein tyrosine phosphatase ptpase albeit specific ptpase involved known current studies aimed identify epec activated ptpase role sert inhibition infection caco monolayers epec strain min increased activity srchomology domain containing ptpase shp shp ptpase similarly western blot studies showed increased tyrosine phosphorylation tyrosine shp indicative activation concomitantly epec infection decreased sert tyrosine levels associated increased interaction shp sert evidenced coimmunoprecipitation studies examine whether shp directly influences sert phosphorylation status function shp cdna plasmid constructs wild type constitutively active dominant negative overexpressed caco cells amaxa electroporation cells overexpressing constitutively active shp sert polypeptide showed complete loss tyrosine addition decrease sert function measured sensitive uptake increase association sert shp caco cells expressing constitutively active shp compared dominant negative shp data demonstrate intestinal sert target shp reveal novel mechanism common food borne pathogen uses cellular shp inhibit sert new noteworthy data presented current study reveal intestinal serotonin transporter sert target tyrosine phosphatase shp show novel mechanism common diarrheagenic pathogen epec activates cellular shp inhibit sert function studies highlight host pathogen interactions may therapeutic relevance management diarrhea associated enteric infections
traditional semiconductor photocatalysts activated near infrared light ultraviolet light owing incoming solar energy near infrared nir light one hottest research topics fabricating photocatalysts driven nir light past decades paper demonstrated photocatalytic principle reviewed synthetic techniques fabrication lanthanide ions doped upconversion nanomaterials semiconductors composited photocatalysts synthetic techniques including epitaxial growth electrospinning chemical assembly discussed carefully also highlighted important applications photodegradation wastewater photoelectrochemical pec water splitting photocatalysts furthermore applications kind photocatalysts driven nir light future prospected
hydrological dispersion module hdm jrodos includes chain models describing washing accidental deposition watersheds rivernet radionuclide transport rivers reservoirs modelling chain hdm renewed integration two models one dimensional model rivtox provides possibilities computing radionuclide transport branched river networks two dimensional model shallow reservoirs river floodplains coastox used algorithms parallel computing unstructured mesh finite volume method renewed modelling chain tested sub watersheds danube river dnieper river
moving synchrony others encourages prosocial behavior adults walk sing tap together later likely cooperative helpful rate likeable previous studies demonstrated interpersonal synchrony encourages helpfulness even month old infants however studies infants always experienced interpersonal synchrony musical context investigated whether synchronous movement nonmusical context similar effects infant helpfulness fourteen month olds bounced gently experimenter faced infant bounced either synchrony contrast previous studies instead listening music interpersonal movement phase bounced infants listened nonrhythmic nature sounds tested infant prosociality directed toward experimenter results showed synchronous bouncing still encouraged prosociality asynchronous bouncing despite absence music however helping delayed fussiness rates much higher previous studies music thus music may necessary interpersonal synchrony influence infant helpfulness presence music may act mood regulator distractor help keep infants happy allow fully experience effects synchronous movement
design safety dfs also known prevention design safe design construction design management promotes early consideration safety health hazards design phase construction project early intervention hazards effectively eliminated controlled leading safer worksites construction processes dfs practiced many countries including australia singapore singapore manpower ministry enacted dfs regulations july enforced august onwards due critical role civil structural engineers design construction dfs knowledge attitude practices kap engineers significant impact successful implementation dfs thus study aims explore dfs kap engineers guide research measuring improving dfs kap designers study found lack kap studies construction management therefore study also aims provide useful lessons future applications kap framework construction management research questionnaire developed assess dfs kap engineers responses provided engineers analyzed addition interviews experienced construction professionals carried understand perceptions dfs related issues results suggest engineers supportive dfs level dfs knowledge practices need improved dfs guidelines training made available engineers ensure dfs implemented successfully need study contractual arrangements clients designers effectiveness different implementation approaches dfs process questionnaire findings study provided foundation baseline survey larger sample size currently planned contrast earlier studies study showed responding engineers supportive dfs study showed key improving dfs kap engineers improving clients motivation dfs elsevier ltd rights reserved
background multistakeholder alliances bring together diverse organizations work health related issues playing increasingly prominent role health care system prior research shows collaborative decision making effective leadership related members perceptions value participation alliances yet know little collaborative decision making leadership might matter time multistakeholder alliances purpose aim study advance understanding role collaborative decision making leadership individuals assessments benefits costs participation multistakeholder alliances time methods draw data collected three rounds surveys alliance members participated robert wood johnson foundation aligning forces quality program findings results regression analyses indicate individuals perceptions value participation alliances shift time perceived value higher collaborative decision making alliances first formed higher effective leadership time passes alliance formation practice implications leaders multistakeholder alliances may need vary behavior time shifting emphasis inclusive decision making task achievement
years debate existed use native american sports mascots however empirical studies topic exist present study examined supraliminal exposure native american mascots results application negative stereotypes toward native american people results indicated effect native american mascots moderated people racial attitudes toward native people exposed native mascots people prejudiced attitude rated native american individual stereotypically aggressive non prejudiced attitude however pattern occur people exposed white mascots neutral images furthermore pattern evident people evaluated non native individual overall pattern results indicates native american mascots selectively facilitate application negative stereotypes resulting harmful evaluations native american people
low impact development lid practices provide sustainable solutions traditional piping storm ponds stormwater management however architects equipped knowledge perform runoff calculations early design stage response dilemma developed open source stormwater runoff evaluation management tool rainwater seamlessly integrated computer aided design cad software receive instant estimate stormwater runoff volume architecture landscape designs designers thereby develop appropriate rainwater management strategies based local precipitation data specific standards site conditions economic considerations employed rainwater conduct two case studies illustrating importance considering stormwater runoff early design stage first case study showed integrating rainwater management design modeling critical determining lid practice specific site second case study demonstrated need visualizing runoff flow direction assisting placement lid practices proper locations terrain great complexity elsevier ltd rights reserved
concurrent perturbations different driver genes reported primarily lymphoma acute myeloid leukemia aml cases concurrent alterations driver genes infrequently reported contrast pathogenetic pathways lymphoma concurrently perturbed genes initial gene alteration aml arrests maturation alteration second gene promote self renewal blasts report unique case infantile leukemia chromothripsis chromosome completely altered band structure resulted concurrent changes moz ncoa fgfr runxt runx multiple hit abnormalities aml reported previously
consider problem minimizing linear function affine section cone positive semidefinite matrices additional constraint feasible matrix prescribed rank rank constraint active non convex optimization problem otherwise semidefinite program find numerous applications especially systems control theory combinatorial optimization even general contexts polynomial optimization real algebra numerical algorithms exist solving problem interior point newton like algorithms paper propose approach based symbolic computation design exact algorithm solving rank constrained semidefinite programs whose complexity essentially quadratic natural degree bounds associated given optimization problem subfamilies problem size feasible matrix fixed complexity polynomial number variables algorithm works assumptions input data prove assumptions generically satisfied also implement maple discuss practical experiments
prism gender relations within couple article analyses married couples manage birth control palestinian territories fertility remains high despite women high level education using data palestinian family health survey conducted detailed interviews married men women conducted analyse prevalence contraceptive use palestinian territories determinants well influence spouse contraceptive choices according type conjugal relationship link gender relations within couple type contraception used although contraceptive use widespread remains subordinate powerful social norm many children especially sons prevails irrespective woman socio demographic characteristics organization fertility control varies according type conjugal relationship depends individual reproductive histories contraception reproduction nevertheless always involve spouses couple emerging main decision making unit
maladherence important factor prevention neurotoxic demoralizing relapses schizophrenia empirical evidence presented organized conceptual four level framework address maladherence effectively prevent demoralizing role classical insight plays neglect underlying motivational processes routine care four level framework address maladherence encompasses functional analysis mal adherence instrumental goal oriented behaviour addressing dysfunctional attitudes relation disorder treatment techniques strengthen therapeutic bond finally focusing obstacles undermining ability adhere
thin films thickness deposited evaporation teo alumina substrates interdigitated silver palladium electrodes evaporation chemical reaction two substances takes place resulting formation oxide matrix finely dispersed phases teo snte depending atomic ratio study morphology structure well determine atomic ratio films electron microscopy techniques tem saed analytical methods eds sem applied electrical properties sensors studied investigated frequency range mhz using precision impedance analyzer measurements taken samples placed controlled humidity temperature chamber characteristics resistance capacitance impedance phase theta functions relative humidity frequency dependences center dot nyquist plots equivalent electrical circuits sensors obtained result relation type water adsorption impedance spectra properties films humidity sensors presented paper
purpose review neuromyelitis optica nmo classically features clinical presentation includes longitudinally extensive transverse myelitis optic neuritis however many pathognomonic phenomena recently described patients diagnosed nmo including intractable hiccups vomiting painful tonic spasms less reported regarding relationship nmo headache though headache well established symptom comorbidity multiple sclerosis much less described thus far nmo literature warrants careful evaluation many questions remain unanswered relationship nmo headache including headache prevalence certain groups distribution primary symptomatic headache disorders seen frequently specific neuroimaging findings associated increased risk headache recent findings various types headache cervicogenic headache trigeminal autonomic cephalalgia like headache reported initial clinical presentation nmo publications emphasized association nmo etiologies headache trigeminal neuralgia pres preeclampsia certain imaging findings medullary lesions patients nmo also associated headache summary link headache nmo evident limited case reports clinical studies also imaging even potential common underlying biomarkers pentraxin interleukin developing understanding association two diseases may lead better management headache patients nmo potentially lead earlier diagnosis nmo headache may serve initial presenting symptom may even herald disease exacerbation
ignition behaviour multiple burner annular combustion chamber consisting bluff body premixed methane air swirl burners investigated experimentally study focusses mechanism lightround namely burner burner flame propagation side visualization spreading flame khz chemiluminescence showed propagation burner burner follow purely azimuthal direction sawtooth pattern downstream sideways motion one burner following bringing flame downstream part recirculation zone adjacent burner convected upstream leading full burner ignition pattern pronounced burners fitted swirlers top visualization image processing used quantify speed lightround function inter burner spacing bulk velocity equivalence ratio swirling feature found flame spread burner burner following two balanced modes propagation turbulent flame propagation combined volumetric expansion inter burner region convection within next ignited burner results presented paper bring new insights ignition realistic gas turbines authors published elsevier inc behalf combustion institute
background epithelial barrier dysfunction increased permeability may contribute antigen sensitization disease progression asthma claudin known lung specific tight junction protein contribution airway barrier function asthma unclear objectives sought test hypotheses claudin determinant airway epithelial barrier function downregulated claudin deficiency results increased aeroantigen sensitization airway hyperresponsiveness methods claudin mrna levels measured airway epithelial brushings healthy controls patients asthma patients asthma claudin levels compared three gene mean marker inflammation airway epithelial permeability changes due claudin deficiency measured hbe cells claudin null mice effect claudin expression determined primary human airway epithelial cells mice airway hyperresponsiveness serum ige levels compared claudin null wild type mice following aspergillus sensitization results epithelial brushings patients asthma significantly lower claudin mrna levels healthy controls claudin levels lowest among high patients asthma loss claudin sufficient impair epithelial barrier function hbe cells mouse airways decreased claudin expression primary human cells mice claudin null mice significantly higher serum ige levels increased airway responsiveness following intranasal aspergillus sensitization conclusions data support hypothesis claudin essential contributor airway epithelial barrier aeroantigens furthermore inflammation suppresses claudin expression potentially promoting sensitization airway hyperresponsiveness
purpose examine association periconceptional self reported stress levels fecund ability women methods daily stress reported scale lowest highest among women completed daily diaries including data lifestyle behavioral factors menstrual characteristics contraceptive use intercourse cycles pregnancy discrete survival analysis used estimate associations self reported stress specific windows menstrual cycle fecundability cycles risk pregnancy adjusting potential confounders results one hundred thirty nine women became pregnant follicular phase reduction fecundability unit increase self reported stress estimated ovulatory window fecundability odds ratio confidence interval attenuated trend preovulatory window luteal phase higher stress associated increased probability conception possibly due reverse causality conclusions higher stress ovulatory window may reduce probability conception however conception occurs changes hormonal milieu knowledge pregnancy may result increased stress findings reinforce need encouraging stress management techniques aspiring expecting mother elsevier inc rights reserved
river water quality monitoring day spatio temporal scales spatial temporal adaptive reflectance fusion model starfm developed estimating turbidity total suspended solid tss six heavy metals iron zinc copper chromium lead cadmium blending moderate resolution imaging spectroradiometer modis landsat spectral bands combination regression analysis genetic algorithm techniques applied develop spectral relationships tss tss starfm algorithm developed relationship models evaluated satisfactorily various performance evaluation measures develop heavy metal pollution index based vulnerability maps resolution brahmani river eastern india monte carlo simulation based analysis developed formulations reveals uncertainty estimating minimum maximum respectively hence remote sensing based approach developed herein effectively used many world rivers real time monitoring heavy metal pollution elsevier ltd rights reserved
sports injuries foot occur sequelae acute trauma chronic overuse besides clinical examination imaging plays major role detection structural abnormalities differential diagnostics article reviews important sports related soft tissue bone pathologies forefoot midfoot together typical findings radiography ultrasound computed tomography magnetic resonance imaging mri
organic claims influence product perceived dimensions unrelated food production method organic food perceived healthful less caloric conventional food claims also bias consumers organic food perceived people judge behavior schuldt schwarz shown individuals evaluating target weight loss goal lenient judging target forgoing exercise target organic conventional dessert impact organic claims leniency judgments interpreted either halo licensing effect current research aim replicate extend schuldt schwarz results examining mechanisms likely explain observed leniency judgments experiment observed leniency towards target consumed organic meal observed target intentionally chooses organic meal choice determined situation findings suggest impact organic claims leniency judgments merely based halo effect instead licensing account emerges probable mechanism experiment found stronger weaker motives forgoing exercise influenced leniency judgments extent organic meal understanding mechanisms shape consumers decisions may important implications prevent bias judgments food exercise elsevier ltd rights reserved
objectives verbal episodic memory key domain impairment people schizophrenia close ties variety aspects functioning therapeutic treatment response randomized blinded trial two mnemonic strategies verbal episodic memory deficits people schizophrenia conducted methods sixty one people schizophrenia assigned one three experimental conditions training mnemonic strategy included visualization narrative structure story method condition participants trained visualize words interacting one another imagery non trained control condition participants received equivalent exposure training word lists verbal memory assessments administered two conditions without provision compensatory mnemonic strategy participants assessed improvements recall word list used part training well two standardized verbal memory assessments included stimuli used part strategy training results story method produced improvements trained word list generalized non trained prose memory task week follow contrast provision mnemonic strategy simple visualization words produced little improvement word recall trained words measures generalization relative performance participants control condition conclusions findings support inclusion enriched mnemonic strategies consisting visualization narrative structure sustained comprehensive programs enhancement verbal episodic memory schizophrenia
logarithmic log domain filters designed using signal graph sfg synthesis approach appropriate set operators following procedure pole log domain filters exactly emulate operation inductor capacitor ladder prototype filter implemented case elliptic log domain filters transmission zeros precisely realized due fact floating capacitors used order approximately perform required differentiations paper alternative sfg representation prototype system done way corresponding filter configuration implemented using log domain lossless integrators amplifiers third order log domain elliptic filter simulated order confirm validity proposed technique
existing complexities teaching learning computer programming increased students diverse disciplinary backgrounds language skills cultures identifying opportunities improvement applying theoretical empirical evidence found literature study presents five framework consistency collaboration cognition conception creativity integrates constructivist collaborative learning theories student centered teaching pedagogy framework found effective postgraduate courses introductory programming three consecutive terms analysis conducted using survey interviews indicates use five framework reduced negative emotional issues motivated students become active learners improved overall performance five framework may thus seen provide model student centered teaching pedagogy helps minimise complexities diverse student cohorts
background mcgill quality life questionnaire widely used people life threatening illnesses without modification since publication use areas improvement emerged therefore various minor modifications tested time aim revise mcgill quality life questionnaire mcgill quality life questionnaire revised maintaining improving psychometric properties length keeping close possible mcgill quality life questionnaire enable reasonable comparison existing mcgill quality life questionnaire literature design data sets eight studies used four studies originally used develop mcgill quality life questionnaire two develop new mcgill quality life questionnaire versions two unrelated purposes mcgill quality life questionnaire revised developed using analyses measurement invariance confirmatory factor analysis calculation correlations mcgill quality life questionnaire global quality life item setting participants data people life threatening illnesses recruited acute palliative care units palliative home care services oncology hiv aids outpatient clinics results mcgill quality life questionnaire revised consists items plus global quality life item new physical subscale created combining physical symptoms physical well new item physical functioning existential subscale reduced four items revised support subscale renamed social focuses relationships psychological subscale remains unchanged confirmatory factor analysis results provide support measurement structure mcgill quality life questionnaire revised overall scale good internal consistency reliability conclusion mcgill quality life questionnaire revised improves replace mcgill quality life questionnaire since contains improved wording somewhat expanded repertoire concepts fewer items single subscale physical domain retaining good psychometric properties
architectures operational amplifiers implemented basis bipolar field jfet transistors offered feature use transistors operating different physical principles precision input circuits differential stages allows set static mode due choice geometric dimensions field effect transistors exclude structure classical sources reference current circuit engineering basic circuits inclusion differential difference operational amplifiers dda based analog gate array master chip agamc ojsc integral minsk low offset voltages provided parameters topology experimental chip class oriented use sensor systems responsible application given
objectives distinguish ethnic differences among segregated schoolgirls restrictive anorexia nervosa using simple culture fair test body image figure drawings methods several responses figure drawings adolescent schoolgirls three ethnically distinct segregated schools communities israel jewish secular jewish haredi christian arab group severely restricting anorexic girls evaluations analyzed mancova followed paired student tests comparisons responses groups respectively pearson served correlations fisher differences slopes results despite total ethnic segregation among schoolgirls commonalities prefer thinner ideal similarly dissatisfied however ethnic differences also emerge underestimate others view true ideal evaluations correlate unlike groups despite variability stark contrast anorexic girls show gross misperception even comparison girls equated bmi discussion findings show figure drawings evaluation simple robust instrument dissociating clinical ethnic responses clinicians may consider body figure drawings simple supportive diagnostic first line recognition risk adolescent girls
paper concerned isochronous centers problem cubic systems equivariant vector field based centers condition compute period constants obtain periodic constants basis center condition separately eleven conditions symbolic computation numerical analysis help computer algebra system mathematica moreover give sufficient necessary condition investigated cubic system pair isochronous centers terms result simultaneous isochronous centers including isochronous centers hardly seen published references result paper new
physical layer security phy security takes advantages channel randomness nature transmission media achieve communication confidentiality authentication wiretap coding signal processing technologies expected play vital roles new security mechanism phy security attracted lot attention due unique features fact daily life relies heavily wireless communications sensitive private information transmissions compared conventional cryptography works ensure involved entities load proper authenticated cryptographic information phy security technologies perform security functions without considering security protocols executed words require implement extra security schemes algorithms layers physical layer survey introduces fundamental theories phy security covering confidentiality authentication provides overview state art works phy security technologies provide secure communications wireless systems along discussions challenges proposed solutions furthermore end paper open issues identified future research directions
mutations tdp cause amyotrophic lateral sclerosis als fatal paralytic disease characterized degeneration premature death motor neurons contribution mutant tdp mediated damage within motor neurons evaluated using mice expressing conditional allele als causing tdp mutant whose broad expression throughout central nervous system mimics endogenous tdp tdp mice develop age mutant dependent motor deficits degeneration death motor neurons cre recombinase mediated excision tdp gene motor neurons shown delay onset motor symptoms appearance tdp mediated aberrant nuclear morphology abrogate subsequent death motor neurons however reduction mutant tdp selectively motor neurons prevent age dependent degeneration axons neuromuscular junction loss attenuate astrogliosis microgliosis thus disease mechanism non cell autonomous mutant tdp expressed motor neurons determining disease onset progression defined mutant acting within cell types
order test therapeutics functional assessments required pre clinical stroke research little consensus regarding appropriate behavioural tasks assess deficits especially testing extended times milder models short occlusion times small lesion volumes study comprehensively assessed different behavioural tests aim identifying show robust reliable stable deficits two months tasks regularly used stroke research well useful examining striatal dysfunction models huntington parkinson disease two cohorts male wistar rats underwent intraluminal filament model middle cerebral artery occlusion min imaged later resulted primarily subcortical infarcts small amount cortical damage animals tested along sham naive groups seven days one two months following behavioural testing brains processed striatal neuronal counts performed alongside measurements total brain white matter atrophy staircase adjusting steps rotarod apomorphine induced rotations reliable assessing long term deficits min transient middle cerebral artery occlusion model stroke
application microscopy evaluate morphology size filamentous proteins amyloids requires new creative approaches simplify automate image processing estimation mean values fibrils diameter length bending stiffness micrographs major challenge purpose developed open source fibril plugin imagej fiji program automatically recognizes fibrils surface mica silicon gold formvar film analyzes calculate distribution fibrils diameters lengths persistence lengths plugin validated processing tem images fibrils formed supnm yeast protein artificially created images rod shape objects predefined parameters novel data obtained sem supnm protein fibrils immobilized silicon gold substrates also presented analyzed program summary program title fibrilj program files doi http dolorg ndxbhvc licensing provisions apache programming language imagej macro language nature problem amyloids large protein aggregates form unbranched fibrils formation amyloids different proteins leads emergence number serious human diseases including alzheimer parkinson huntington diseases therefore various amyloids particular topology widely studied enormous number papers structural organization amyloid aggregates molecular level key problem area moment new methods amyloids analysis based electronic probe microscopy particularly popular usually required process images containing hundreds amyloids obtain statistically reliable data distribution thickness length persistence length basic mechanical property quantifying stiffness polymer lattermost parameter introduced chatkteristic bending stiffness amyloids similarly model wormlike chain polymers manual measurements parameters take lot time due human factor insufficiently representative imagej fiji open source software one commonly used program image processing imagej fiji community provides bonej plugin bones analysis diameter plugin nanofibers analysis function determining diameter respective objects also approaches involve calculations end end distances contour lengths biopolymers used determine persistence lengths using imagej fiji mentioned plugins designed study amyloids never used validated provide necessary functionality automatic recognition amyloids substrate filtering objects number parameters unspecified accuracy objects measurements calculate objects distribution average diameters persistence lengths solution method purpose developed fibril plugin imagej fiji program open source code automatically recognizes fibrils surface mica silicon gold formvar film analyzes calculate distribution fibrils average diameters lengths persistence lengths fibrilj usage may unify process diameter persistence length calculation may also contribute comparison results obtained different research groups plugin fibril presentedin paper free diameter bonej weaknesses validated artificially created images rod shape objects predefined parameters micrographs supnm protein fibrils elsevier rights reserved
young individuals better memorize initially seen faces emotional rather neutral expressions healthy older participants alzheimer disease patients show better memory faces positive expressions socioemotional selectivity theory postulates positivity effect memory reflects general age related preference positive stimuli subserving emotion regulation another explanation might older participants use compensatory strategies often considering happy faces previously seen question existence effect tasks permitting compensatory strategies still open thus compared performance healthy participants patients positive neutral negative faces tasks healthy older participants patients showed positivity effect memory difference emotional neutral faces young participants results suggest positivity effect memory entirely due sense familiarity smiling faces
phosphorus export lowland polders caused severe water pollution numerical models important resource help water managers control export study coupled three models phosphorus dynamic model polders pdp integrated catchments model phosphorus dynamics inca universal soil loss equation usle describe dynamics polders based coupled models data set collected polder jian china sensitivity analysis carried analyze cause effect relationships environmental factors export frompolder jian sensitivity analysis results showed export polder jian strongly affected air temperature precipitation fertilization proper fertilization management strategic priority reducing export polder jian study demonstrated success model coupling application investigating potential strategies support pollution control polder systems elsevier rights reserved
background objectivelung cancer prevalent among patients interstitial pneumonia hrct findings mucinous adenocarcinoma patients described methodsin consecutive patients surgically resected associated lung cancers patients pathologically proven invasive adenocarcinoma total patients men women mean age years invasive mucinous adenocarcinoma reviewed patients medical records hrct scans resultsinvasive mucinous adenocarcinoma commonly associated idiopathic affecting lower lobe adjacent fibrocystic changes patients invasive mucinous adenocarcinoma types tumour adjacent fibrocystic lesion invasive mucinous adenocarcinoma malignant signs included lobulation spiculation vascular convergence pleural indentation characteristic findings mucinous adenocarcinoma vague margins lobular bounded margins air bronchogram bubble like low attenuation common invasive mucinous adenocarcinoma types invasive mucinous adenocarcinoma tumours closely associated fibrosis conclusionmixed ground glass opacity consolidation adjacent fibrocystic lesion malignant signs characteristic features mucinous adenocarcinoma indicate malignancy study describes unique hrct features invasive mucinous adenocarcinoma patients interstitial pneumonia signs malignancy like lobulation spiculation vascular convergence pleural indentation together vague margins lobular bounded margins air bronchogram bubble like low attenuation indicative invasive mucinous adenocarcinoma
background studies associations utero hydroxyvitamin exposure risk childhood asthma wheeze respiratory tract infections inconsistent inconclusive objectives sought assess associations levels cord blood maternal venous blood risk offspring asthma wheeze respiratory tract infections methods data derived pubmed embase google scholar references relevant articles novo results published studies december random effects meta analysis conducted among birth cohort studies results comparing highest lowest category levels pooled odds ratios asthma wheeze respiratory tract infections observed inverse association wheeze pronounced became statistically significant studies measured levels cord blood conclusions accumulated evidence generated meta analysis suggests increased utero exposure inversely associated risk asthma wheeze childhood findings keepingwith results recently published randomized clinical trials vitamin supplementation pregnancy
model transformations important cornerstone model driven engineering discipline facilitates abstraction relevant information system models success final system mainly depends optimization models model transformations currently application transformations realized either following apply long possible strategy provision explicit rule orchestrations implies two main limitations first optimization objectives implicitly hidden transformation rules orchestration second manually finding best orchestration particular scenario major challenge due high number possible combinations overcome limitations present novel framework builds non intrusive integration optimization model transformation technologies particular formulate transformation orchestration task optimization problem allows efficient exploration transformation space explication transformation objectives generic framework provides several search algorithms guides user providing proper search configuration present different instantiations framework demonstrate feasibility applicability benefits using several case studies copyright john wiley sons ltd
boost converters indirect energy transfer topologies transient oriented controllers designed facilitate dynamic response may range minimum time minimum output voltage deviation since analytical definitions control laws become quite complex large signal stability verification immediate paper explores existence stability indirect energy transfer converters controlled either boundary hybrid controllers introduces new simplified procedure examination large signal stability given converter load type using graphical analytical approach stability analysis examination method demonstrated boost converter loaded resistive load constant current load stability conditions verified using boost converter prototype controlled programmable deviation controller time optimal controller verifying large signal stability
distributed query processing paramount importance next generation distribution services internet things iot cyber physical systems even several multi attribute range queries supports proposed peer peer systems solutions must rethought fully meet requirements new computational paradigms iot like fog computing paper proposes dragon efficient support distributed multi dimensional range query processing targeting efficient query resolution highly dynamic data dragon nodes edges network collect publish multi dimensional data nodes collectively manage aggregation tree storing data digests exploited resolving queries prune sub trees containing relevant matches multi attribute queries managed linearizing attribute space space filling curves extensively analysed different aggregation query resolution strategies wide spectrum experimental set ups show dragon manages efficiently fast changing data values show dragon resolves queries contacting lower number nodes compared similar approach state art elsevier rights reserved
current evidence randomised controlled trials effects dietary fibre intake breast cancer risk inconsistent conducted meta analysis determine effectiveness dietary fibre intake reducing breast cancer risk searched prospective case control studies dietary fibre intake breast cancer risk english language march twenty four epidemiologic studies obtained pubmed embase web science cochrane library databases systematically reviewed random effects model used compute pooled risk estimates extracting risk estimate highest lowest reported categories intake study meta analyses showed decrease breast cancer risk dietary fibre intake association dietary fibre intake breast cancer risk significant stratified according jadad scores study types menopause status dose response analysis showed every increment dietary fibre intake associated reduction breast cancer risk little evidence publication bias found thus dietary fibre consumption significantly associated reduced risk breast cancer particularly postmenopausal women
purpose reviewthe importance gut microbiome human health increasingly recognized purpose review examine existing literature pertaining alterations gut microbiome utility microbiome restoration therapies gastrointestinal disorders recent findingsimbalance maladaptation microbiome termed dysbiosis associated several disease states irritable bowel syndrome clostridium difficile infection inflammatory bowel diseases nonalcoholic fatty liver disease obesity among others possibility restoration normal microbiota become attractive concept diseases normal microbiome perturbed rationale using fecal microbiota transplantation treat disease validated successful use treating recurrent clostridium difficile infection occurs result decreased microbial diversity gut often setting recent antibiotic treatment similar strategies may applicable disorders summaryalterations gut microbiome associated several disorders microbiome restoration based therapies fecal microbiota transplantation may adjunct conventional treatments investigation needed
although individuals substance use disorders sud treatment continue smoke high rates regulatory policy programming changes promoting tobacco cessation implemented patients quit successfully examined associations smoking patterns tobacco advertising receptivity anti tobacco message awareness health risk perception attitudes towards addressing smoking availability smoking cessation services quitting smoking sud treatment surveys completed patients programs chosen randomly stratified program type residential methadone maintenance outpatient among publicly funded adult treatment programs within national drug abuse treatment clinical trials network among respondents sud treatment least one month current smokers former smokers reported quitting smoking treatment least one month prior survey completion respondents comprised sample results showed participants reported health concerns reason quitting times likely quit treatment reporting health concerns affected quitting little additionally participants reported smoking cessation part personal treatment plan sud treatment times likely quit treatment participants methadone treatment less likely report successfully quitting treatment outpatient treatment leveraging health concerns smoking including smoking cessation individualized treatment plan may help increase smoking cessation sud treatment elsevier inc rights reserved
migraine common neurological disorder significantly higher incidence prevalence women men presentation disease women modulated changes sex hormones adolescence pregnancy menopause yet effect sex influences often neglected basic clinical clinical management disease review evidence epidemiological clinical animal neuroimaging studies significance sex related influences migraine presented unmet needs area discussed wiley periodicals inc
cerebral small vessel disease considered hereditary patients characterized lacunar infarcts white matter hyperintensities mri several monogenic hereditary diseases causing cerebral small vessel disease stroke identified purpose systematic review provide guide determining consider molecular genetic testing patients presenting small vessel disease stroke cadasil carasil collagen type mutations including padmal retinal vasculopathy cerebral leukodystrophy fabry disease hereditary cerebral hemorrhage amyloidosis forkhead box mutations described terms genetics pathology clinical manifestation imaging diagnosis monogenic disorders often characterized early age stroke also migraine mood disturbances vascular dementia often gait disturbances also present extra cerebral manifestations microangiopathy eyes kidneys many present clinically recognizable syndromes investigations include thorough family medical history medical history neurological examination neuroimaging often supplemented specific examinations vision retinal changes well kidney heart function however molecular genetic analysis final gold standard diagnosis increasing numbers reports new monogenic syndromes causing cerebral small vessel disease genetic counseling important enzyme replacement therapy possible fabry disease treatment options remain overall limited elsevier rights reserved
background radiotherapy localised prostate cancer many known distressing side effects efficacy group interventions reducing psychological morbidity lacking study investigated relative benefits group nurse led intervention psychological morbidity unmet needs treatment related concerns prostate cancer specific quality life men receiving curative intent radiotherapy prostate cancer methods phase iii two arm cluster randomised controlled trial included men consent rate attrition randomised intervention usual care intervention comprised four group one individual consultation delivered specialist uro oncology nurses primary outcomes anxious depressive symptoms assessed hospital anxiety depression scale unmet needs assessed supportive care needs survey revised treatment related concerns cancer treatment scale quality life expanded prostate cancer index assessments occurred end months post radiotherapy primary outcome analysis intention treat performed fitting linear mixed model outcome separately using observed data results mixed models analysis indicated group consultations significant beneficial effect one two primary endpoints depressive symptoms one twelve secondary endpoints procedural concerns related cancer treatment group consultations significant beneficial effect generalised anxiety unmet needs prostate cancer specific quality life conclusions compared individual consultations offered part usual care intervention provides means delivering patient education associated modest reductions depressive symptoms procedural concerns future work seek confirm clinical feasibility cost effectiveness group interventions
accurately construct topographic information six legged walking robot real time study proposes stereo matching algorithm conduct disparity estimation pixel using bayesian posterior probability model based gpu accelerated parallel processing proposed algorithm supporting points construct disparity space obtain prior distribution probability density pixel substitute bayesian posterior probability model establish energy function disparity estimated disparity value unknown pixel obtained minimizing energy function performing consistency check left right sides image mismatching pixel eliminated according disparity value supporting point disparity filling mismatching area achieved applying adaptive weight method basis cross extending obtain accurate density disparity map parallel computing stage proposed algorithm performed using compute unified device architecture reduce running time experimental results show proposed algorithm good robustness different illuminations texture curved surface reconstruction algorithm also adapt fast matching images different sizes reconstruct disparity map scenes real time resolution ratio stereoscopic vision test board employed construct disparity map real scenes verify practical application effect algorithm good experiment effect achieved elsevier rights reserved
introduction lenalidomide immunomodulatory drug imid unique mode action moa may vary across disease type currently approved multiple myeloma myelodysplastic syndrome mds mantle cell lymphoma mcl yet also clinically active host lymphoproliferative diseases including chronic lymphocytic leukemia cll due protean effects immune system lenalidomide may particularly appealing cll distinct ability evade immune recognition cause immunosuppression areas covered review recaps biological mechanisms lenalidomide specific cll summarizes clinical data previously untreated relapsed refractory cll patients emphasis toxicity moreover lenalidomide treatment put context highly effective targeted agents drastically changing therapeutic approach cll expert opinion lenalidomide potent drug cll first line relapse however comparison newly available agents lenalidomide slow onset efficacy notable toxicity profile limits single agent use combinations chemotherapy future trials hopefully direct ability harness lenalidomide moa best incorporate rapidly evolving landscape cll treatment
paper devoted comparison numerically simulated chua circuit real circuit aim research figure factors affecting computer simulation accuracy find ways improve discovered influence exerted inaccuracy nonlinear chua diode characteristic measurement numerical integration method used simulation operational amplifier properties possibility analog circuit application source accurate signal order find appropriate numerical method chaotic systems simulation shown
studied long term sequelae hand injuries result playing volleyball retrospective study patients injuries hand seen year period trauma department investigated females accounted injuries mean age years peak age group years sprains strains observed frequently followed fractures contusions fingers involved cases injuries hand occurred recreational players recreational players left sided injuries whereas competition players right sided injuries suggesting lack skill important determinant left handedness associated increased risk hand injury recreational players one third volleyball players work school median weeks result injury survey mean period years high percentage patients complaints cited stiff crooked fingers limitations tenderness movements main inconveniences consider incidence disturbingly high regarding seemingly innocent nature injuries
describe evaluate software implementation novel mechanism accessing streaming gpu rendered content cloud low end user devices unique properties implementation enable trivial cloud deployment graphics intensive applications even ones originally intended run cloud achieve goal creating virtual gpu nodes appear application like hardware devices incur overhead virtualization low level access frame buffer maximizes number applications work box without system imposing specific display manager windowing system
background knowledge available relationship obstructive sleep apnea osa cognitive impairment stroke limited evolution osa cognitive performance stroke sufficiently described methods prospectively enrolled examined acute stroke patients without previously diagnosed osa following information collected demographics sleep cardio respiratory polygraphy day seven month three month stroke post stroke functional disability tests entry months three cognition attention orientation memory verbal fluency language visual spatial abilities using revised addenbrooke cognitive examination ace months three results patients completing study osa diagnosed patients mean apnea hypopnea index ahi study entry spontaneously declined month osa group total ace score significantly reduced months three osa group poorer performance subtests memory months verbal fluency months observed osa group compared non osa group visual spatial abilities osa non osa groups total ace score osa non osa groups improved conclusions high prevalence osa cognitive decline present patients acute stroke spontaneous improvements osa cognitive impairment observed elsevier rights reserved
metabolic disorders obesity diabetes nowadays regarded diseases affecting majority population diseases develop gradually time individual recently systematic experiments tracking disease progression conducted giving high throughput complex data pressing need developing methods analyze complex data capture disease mechanism molecular level diseases usually develop perturbations biological processes organism study tried capture interlinking different biological processes work together regulate disease phenotype considered temporal microarray data experiment conducted study obesity diabetes mice analyzed data obtain perturbed biological processes developed methods establish link perturbed biological processes derived mathematical formula score genes identified significant set genes regulating complex process network methods developed study also applicable broad array data types
one promising ways solving water scarcity problem world distillation ocean salt water thermal methods method competitive methods required thermal energy supplied recovering heat wastes energy systems gas turbine power plant paper combined cycle solid oxide fuel cell sofc used thermal resource multiple effect desalination system combination three system leads reduce total energy consumption reduce exhaust pollutants reduce operation maintenance cost well increasing total efficiency comparison conventional individual systems exergoeconomic analysis hybrid system performed find technical economical optimal working point system costs revenues estimated effect two important design parameters operational temperature current density sofc exergy efficiency levelized cost electricity lcoe investigated implementing optimization system calculating optimal values design parameter leads rise exergy efficiency levelized cost electricity decreased kwh elsevier rights reserved
background seasonal affective disorder sad subtype recurrent depressive bipolar disorder characterized regular onset remission affective episodes time year aim present study provide epidemiological data data socioeconomic impact sad general population austria methods conducted computer assisted telephone interview randomly selected subjects females males using seasonal health questionnaire shq seasonal pattern assessment questionnaire spaq sheehan disability scale sds telephone numbers randomly drawn austrian telephone books transformed using random last digits method last birthday method employed choose target person interviews results subjects fulfilled criteria seasonal pattern specifier according dsm diagnosed sad applying icd criteria fulfilled sad diagnostic criteria prevalence fall winter depression according kasper rosenthal criteria determined criteria fulfilled subsyndromal sad sad find statistically significant gender differences prevalence rates using dsm gold standard diagnosis sad diagnosis derived spaq yielded sensitivity specificity subjects sad significantly higher scores sds higher rates sick leave days reduced productivity healthy subjects conclusions prevalence estimates sad shq lower spaq data indicative substantial burden disease socioeconomic impact sad epidemiological data shows lack gender differences sad prevalence higher rates females clinical sad samples might least part explained lower help seeking behaviour males elsevier masson sas rights reserved
microelectromechanical systems utilized alongside transistor amplifiers resistive connections implementing oscillatory associative memories phase locking studied network requirements circuit level implementation satisfied high gain trans impedance amplifier operating ghz addition novel automatic amplitude control circuit employed remove amplitude dynamics system requiring resonator characteristics extracted calculated well new method initialization network proposed neuron consumes power supply convergence time typical network trained hebbian rule less results ultra high speed analog signal processing system
purpose developing optimized project schedule considers decision criteria represents challenge project managers purpose paper provide multi objectives overall optimization model project scheduling considering time cost resources cash flow development aims overcome limitations optimizing objective resulting non overall optimized schedule design methodology approach paper multi objectives overall optimization model project scheduling developed using particle swarm optimization new evolutionary strategy based compromise solution pareto front model optimizes important decisions affect given project including time cost resources cash flow study assumes activity different execution methods accompanied different time cost cost distribution pattern multiple resource utilization schemes findings applying developed model schedule real life case study project proves proposed model valid modeling real life construction projects gives important results schedulers project managers proposed model expected help construction managers decision makers successfully completing project time reduced budget utilizing available information resources originality value paper presented novel model four main characteristics produces optimized schedule considering time cost resources cash flow simultaneously incorporates powerful particle swarm optimization technique search optimum schedule applies multi objectives optimization rather single objective uses unique pareto compromise solution drive fitness calculations evolutionary process
increasingly recognised abundant resources evolutionized biological materials structures provide exciting opportunity growth area materials engineering impact projectile resistance bio inspired cellular structural system developed contain radial fracture damage mortar due projectile impact boundary impedance mismatch utilizing adjacent cells mutual confining mechanism improve penetration resistance penetration resistance evaluated hexagon cell confined mutually six identical neighbouring cells rigid mould subjected diameter aisi high strength steel projectile impact similar three cell sizes two types cellular interface material air silicone investigated compared monolithically cast mortar control specimens respective sizes found cellular design effective significantly reducing radial damage incoming projectile modest increase penetration depth furthermore specimens silicon cellular interface material demonstrated reduction proximal crater damage across specimen sizes tested increase penetration depth numerical simulations using dyna quarter symmetry also led better understanding physical shockwave interactions modified cellular design allowed verification experimental results supported authors explanations physical phenomena overall penetration depths crater diameters within experimental results respectively research useful field applications extensive radial damage costly repair penetration resistance critical consideration elsevier ltd rights reserved
undergraduate chemical engineering students trained differently disciplines control theory aspen hysys provides basic modules unit operation dynamics used elucidating intended principles control students virtually available matlab simulink total six workshops designed laboratory course starts familiarizing students dynamic feature commercial software students introduced operational safety aspects solving runaway cstr model importance transfer functions elucidated approach integrate different electrical devices frequency response analysis presented using transfer function visualize instability two experiments designed pid controller students envisage affect tuning parameters absolute integrated error offset regulation manipulated variable different tuning methods objectives also explained comparison simulink hysys simulation discussed modules provided supplement material surveys direct assessment tools evaluate student understanding course results compared previous session using simulink laboratory tool presenting higher satisfaction hysys wiley periodicals inc
objective data effect hormone replacement therapy hrt tibolone lipoprotein independent risk factor cardiovascular disease heterogeneous conflicting studies effect hrt tibolone concentrations post menopausal women reviewed meta analysis design methods medline scopus embase cochrane databases searched february two researchers identified randomized controlled studies extracted data potential controversies resolved third reviewer results eligible studies hrt caused significant reduction concentrations compared placebo treatment mean relative difference confidence interval significant heterogeneity studies without evidence publication bias significant effect found tibolone mean relative difference without publication bias oral estrogen caused greater reduction concentrations transdermal estrogen mean relative difference significant heterogeneity studies evidence publication bias difference observed continuous compared cyclical hrt conventional low dose estrogen estrogen monotherapy estrogen combined progestogen difference observed hrt tibolone regarding effect conclusions hrt significantly decreases concentrations oral effective trans dermal estradiol type hrt dose estrogen addition progestogen seem modify lowering effect hrt elsevier rights reserved
recent years development photovoltaic system photo thermal system technology hybrid photovoltaic thermal pvt technology breakthrough many aspects paper describes movable hybrid pvt system aspects appearance structure energy flow control circuit system equipped rolling wheels simulated light sources also removed system used outdoor conditions movable system also suitable pvt system related applications without external power supply system combines two technologies photovoltaic power generation photo thermal utilization first part power supply systems output power supply second part generating thermal energy two separate parts controlled monitored respectively control circuits touch screens experimental results show system generate kwh electric energy kwh thermal energy year normal working conditions efficiency proposed movable hybrid pvt system calculated approximately using revised equations proposed paper therefore movable hybrid pvt system meet daily demands hot water electricity power remote areas islands non grid areas also used conduct experiment tests pvt system
background total knee arthroplasty tka common generally effective procedure performed mainly due advanced osteoarthritis pain physical disability reduced quality life however approximately patients respond poorly surgery chronic pain disability following tka remains major health burden many patients among well documented powerful psychological predictors poor outcome following tka pain catastrophizing recent research shown patients thoughts higher risk persistent pain lower physical function operation patients low levels pain catastrophizing tka high need developing treatments aimed improving self management group patients aim study investigate effectiveness patient education pain coping physical function pain among patients high pain catastrophizing score tka methods study two arm parallel group trial design including patients high levels pain catastrophizing referred total knee arthroplasty due osteoarthritis patients eligible participation randomized two arms usual care usual care patient education usual care consists operation standard rehabilitation patient education consists individual sessions focusing pain behavior pain coping managed physiotherapist three operation four measurements taken baseline operation months operation primary outcome pain months measured vas visual analogue scale secondary outcomes include physical function activity quality life pain management psychological factors discussion studies evaluated effectiveness psychological interventions patients high levels pain catastrophizing operation trial provide evidence effectiveness cognitive behavioral patient education delivered physiotherapists may provide better functional outcome less pain vulnerable group tka patients expect results provide important new knowledge current care recommendations
paper refers approach used science specifically building materials engineering assuming possibility material modeling including modeling technical characteristics building materials various compositions well modeling phenomena processes occur use materials structures made authors analyze merits approach modeling context compliance computational models reality consider significance selection proper model type mathematical function number input data based knowledge modeled material phenomenon later adequate verification model authors also underline importance proper interpretation results obtained calculation misrepresentation may result misstated model studied phenomenon lead incorrect conclusions puts researcher far truth always seek
framework models generated compositional expressions solve two topical marginalization problems namely single marginal problem marginal representation problem solved special class called canonical expressions also show two problems solved scratch preliminary symbolic computation
frontotemporal dementia neurodegenerative disease affecting cognition behavior multiple devastating ways article highlights diagnostic features helpful differentiating frontotemporal dementia dementias commonly alzheimer disease
spironolactone known anti androgen drug proven effective treatment acne quest minimize unnecessary systemic side effects associated oral drug administration spironolactone led growing interest loading lipid nanoparticles deliver drug topical formulation aim current investigation prepare compare performance loaded nanostructured lipid carrier nlc alcoholic gels alc two groups respective patient populations group group treatment mild moderate acne vulgaris results showed nlcs spherical shape average diameter similar polydispersity index zeta potential nanoparticles respectively gels showed non newtonian independent pseudoplastic shear thinning behavior nlcs toxic fibroblast cell strains periods results showed mean number total lesions non inflammatory lesions group significantly decreased respectively similar pattern observed group mean number total lesions non inflammatory lesions reduced respectively total lesion count tlc significantly decreased group group respectively treatment nlc weeks water content skin significantly increased instrumental units therefore nlc gel may help controlling acne vulgaris skin care benefits elsevier rights reserved
paper presents reference modification model digitally controlled converter proposed method able obtain superior transient response modifies reference conventional feedback loop change output voltage modifying process operates transient state steady state feedforward control cancels steady state error since feedforward control uses load current value paper discusses two current sensing methods one output current sensing method using sensing resistor reactor current sensing method using filter discussed order reduce performance loss sensing resistor result output current sensing method effective case high transient response performance required hand better use reactor current sensing method efficiency important
hepatitis virus hev infections limited liver may also affect organs several diseases including guillain barre syndrome neuralgic amyotrophy glomerulonephritis cryoglobulinemia pancreatitis lymphoma thrombopenia meningitis thyroiditis myocarditis observed context hepatitis date definite pathophysiological links hev extrahepatic manifestations yet established however suggested hev infection might causative based serological studies case series vitro data animal models particular neuronal renal diseases well pancreatitis seem caused hev causative relationship hev diseases doubtful either direct cytopathic tissue damage extrahepatic replication immunological processes induced overwhelming host immune response possible origins hev associated extrahepatic manifestations hepatologists aware possibility acute chronically hev infected patients could develop extrahepatic manifestations neurologists nephrologists rheumatologists groups physicians consider hev infection potential differential diagnosis observing one diseases described review ribavirin steroids used small groups patients extrahepatic manifestations hev efficacy drugs still needs verified large multicenter studies article comprehensively reviews published literature regarding hev extrahepatic manifestations discuss probability specific extrahepatic diseases caused previous ongoing hev infection summarize published knowledge antiviral treatment extrahepatic disorders european association study liver published elsevier rights reserved
despite heightened interest human reproduction significant implications premarital pregnancy children health strikingly little research paid attention determinants premarital pregnancy compared conventional fertility behavior fill gap literature study drew data korean longitudinal survey women families estimated discrete time event history models using multinomial logistic regressions results descriptive analyses indicate share premarital pregnancy among births registered increased roughly two half times also premarital conception increased women educational levels high school graduates less elementary school education showed largest increase share premarital pregnancy results multivariate models suggest characteristics women family origin firstborn child mother education living arrangements adolescence region residence enduring effects premarital post martial pregnancy women achieved socioeconomic status however showed weaker effect odds premarital pregnancy expected predicted probabilities premarital pregnancy age first marriage across birth cohorts born suggest premarital pregnancy particularly pronounced among women marry early twenties moreover given age first marriage predicted probability premarital pregnancy monotonically increases recent birth cohorts suggesting bridal pregnancy increasingly prevalent among modern korean women
background ascending thoracic aortic aneurysm ataa major cause morbidity mortality worldwide pathogenesis medial degeneration aorta remains undefined high throughput secretome analysis mass spectrometry may useful elucidate molecular mechanisms involved aneurysm formation well identify biomarkers early diagnosis targets therapy purpose present study analyze secreted released proteins ataa specimens tricuspid aortic valve tav bicuspid aortic valve bav patients methods aortic specimens collected patients undergoing elective surgery requiring graft replacement ascending aorta sample ascending aortic aneurysm bav males aged years tav male years incubated serum free medium released proteins digested trypsin peptide mixtures fractioned nano high performance liquid chromatography analyzed mass spectrometry following identification differentially expressed proteins quantitative real time polymerase chain reaction qrt pcr analysis performed results comparison proteins released bav tav aneurysmatic tissues showed significantly diverging expression fingerprints two groups patients bioinformatics analysis revealed differentially released proteins particular proteins regulated regulated bav respect tav proteins released bav related activation transforming growth factor tgf beta signaling latent tgf beta binding protein ltbp exhibited one highest significant expressions fold change bav secretomes respect tav qrt pcr analysis validated significant difference ltbp gene level bav tav conclusion hypothesis free secretome profiling clearly showed diverging expression fingerprints ataa tav bav patients confirming crucial role tgf beta signaling modulating ataa development bicuspid patients japanese college cardiology published elsevier ltd rights reserved
general synthesis method realisation nth order current transfer function derived signal flow graph proposed method novel configuration nth order current mode universal filter using differential voltage current conveyors dvccs multiple outputs dvcc modvcc obtained number active elements configuration reduced significant reduction comparison previously reported methods proposed circuits employ features multifunctional smallest number elements simple structure easy cascaded convenient integration examples biquadratic filter four different orders filters realised cmos process simulation results given demonstrate effectiveness schemes simulation results found good agreement theory
catabolism tryptophan kynurenine kyn pathway several endogenous metabolites neuromodulatory properties produced kynurenic acid kyna one highest significance causal role altered kyna production described several neurodegenerative neuropsychiatric disorders parkinson disease huntington disease schizophrenia therefore kynurenergic manipulation aim therapy recently proposed conventionally kyna produced precursor kyn aid astrocytic kynurenine aminotransferase kat murine brain although mouse standard therapeutic research organism presence kat mice described detail study demonstrates presence kat mrna protein throughout adult cbl mouse brain addition former expression data rat found prominent kat expression astrocyte also neurons several brain regions hippocampus substantia nigra striatum prefrontal cortex significant number kat positive neurons positive gad presence kat enzyme could also demonstrate mice brain homogenate cells overexpressing recombinant mouse kat protein new finding attributes new role interneuron derived kyna neuronal network operation furthermore results suggest thorough investigation spatio temporal expression pattern relevant enzymes kyn pathway prerequisite developing understanding pharmacological transgenic murine models kynurenergic manipulation
soil structure interface structures frozen soil ground important element structure safety permafrost regions interface usually subjected constant normal stress cyclic shear loadings seismic wind wave loadings hence cyclic direct shear behaviors interface critical impacts safety durability structure paper investigated cyclic direct shear behaviors artificial frozen soil structure interface four constant normal stresses four sub zero temperatures using large scalemulti functional direct shear apparatus cyclic shear stress normal displacement measured normal stresses kpa sub zero temperatures degrees respectively measurements revealed following mechanical properties artificial interface maximum shear stress always observed initial stage first cycle maximum shear stress linearly related normal stress internal friction angle cohesion interface maximum shear stress decrease increase sub zero temperature internal friction angle decreases cycles angle becomes significantly smaller stabilized cycles first cycle maximum dilation measured normal displacement always observed first cycle dilation decreasing higher normal stress lower sub zero temperature however final normal displacement always contracts magnitude increases increase normal stress decrease sub zero temperature finally simple damage model proposed describe behaviors artificial interface performance checked prediction experimental data elsevier rights reserved
orexin receptors oxrs implicated motivation drugs abuse utilized within session behavioral economics threshold procedure screen individual differences economic demand ultra short acting opioid remifentanil test whether antagonism oxrs reduces remifentanil demand behavioral economics procedure revealed robust individual differences free consumption remifentanil parameter hedonic set point rats low baseline low takers displayed high demand elasticity parameter reduced responding drug price increased indicating low motivation drug whereas subjects higher high takers exhibit low demand elasticity low continuing self administer remifentanil despite increased cost reflecting higher motivation drug punished responding paradigm utilizing footshock subjects classified high takers baseline withstood twice much shock low takers continue self administering remifentanil interestingly oxr antagonism reduced increased low takers high takers similarly oxr antagonist attenuated cue induced drug induced reinstatement remifentanil seeking low takers significant effect reinstatement drug seeking high takers together data reveal novel role orexins demand remifentanil oxrs modulate demand low takers individuals exhibit addictive like behaviors high takers finally behavioral assays study serve novel laboratory model studying individual differences opioid use disorders
micrometeorological measurements used evaluate heat water vapor describe transpiration soil evaporation processes wide narrow runoff strips field rainwater harvesting irwh system resulting sigmoid shaped water vapor wide narrow runoff strips varied lower upper parts maize canopy wide runoff strips lapse conditions extended lowest measurement level upper middle section inversion apparent top canopy virtual potential temperature theta profile showed difference middle section lower upper portion lower theta narrow compared wide strips changes observed respectively within canopy increased concentration determined wind order magnitude concentration reached peak kpa range wind speed value wide narrow treatments respectively sparse maize canopy wide strips could supply drying power air response atmospheric evaporative demand compared narrow strips due variation air flow wide narrow runoff strips change gradients evapotranspiration processes
high resolution dimensional cartilage specific magnetic resonance imaging mri performed test following hypotheses nonuniform cartilage thickness distribution proximal humerus glenoid surface glenohumeral joint combined system congruent level joint cartilage surface without substantial radial mismatch inclusion volunteers females mean age years range years prospective study measurements cartilage thickness regions zones radius circles glenoid humeral cartilage congruency calculation using mri dimensional dual echo steady state sequence water excitation homogenous mean cartilage thickness slightly higher values glenoidal articulating surface radii mid paracoronar section mid paraaxial section compared humeral side observed concept radial mismatch humeral head glenoid healthy human subjects confirmed study provides normative data comparison joint cartilage changes shoulder future studies
need faster power system dynamic simulations increases essential develop new algorithms exploit parallel computing accelerate simulations paper proposes parallel algorithm based two level schur complement based domain decomposition method two level partitioning provides high parallelization potential coarse fine grained addition due schur complement approach used update sub domain interface variables algorithm exhibits high global convergence rate finally provides significant numerical computational acceleration algorithm implemented using shared memory parallel programming model targeting inexpensive multi core machines performance reported real system well large test system combining transmission distribution networks
paper presents development portable thermogenerator designed work uncontrolled heat sources thermal behavior regarding steady state transient regimens analytically described numerically solved using lumped capacity model ranges heating power power increasing rates determined ensure safe operation give users advance warning case failure addition model useful tool designing controller system based feasible thermogenerator developed experimental tests performed prototype based commercial bite module demonstrated goal
study investigates performance existing vegetation indices retrieving chlorophyll content semi arid mixed grass prairie ecosystem across scales using situ data collected published broadband narrowband vegetation indices evaluated estimate chlorophyll content results indicate narrowband indices utilize reflectance data one wavelengths red edge region similar perform better broadband indices found effective narrowband indices chlorophyll content estimation leaf canopy scales empirical relationships generally stronger canopy leaf scale attributable fact leaf samples collected peak growing season chlorophyll plant species uniform spot casi derived chlorophyll maps result map accuracies respectively assessment vegetation chlorophylls canopy level especially using remote sensing imagery important providing information pertaining ecosystem health physiological status productivity phenology vegetation international society photogrammetry remote sensing inc isprs published elsevier rights reserved
order ensure robotic hand successfully grasp objects without damaging active compliance control useful technique provide safe grasping particular paper establishes direct force control finger adaptive robot gripper using pid control modified fsr force sensor plastic cover used ensure contacted force grasping measured recorded series grasping tests performed observe performance pid control experimental results show pid control simple reliable control scheme provide active compliance control direct force control addition different compliance level feasible particularly stiff spongy ball
purpose purpose paper introduce novel design topology electric motor essentially none normal sources magnetic alternating force design methodology approach two dimensional three dimensional finite element methods used analyze electromagnetic performance proposed machine integral equations used calculate scalar potentials detailed manufacturing process results testing presented findings new design eliminate core vibrations slot passing frequency vibrations torque pulsations motor also property external magnetic field controllable tunable construction social implications approach increases motor efficiency originality value proposed machine low field vibration used low exterior fields required
series coupled thermo hydraulic simulations performed soil geotextile column understand effect temperature suction distribution throughout soil column hydraulic performance geotextile drainage capillary barrier layer two different constant temperatures degrees degrees temperature gradient degrees along column modeled changing temperature degrees degrees significant effect suction head distribution soil geotextile column temperature gradient resulted appreciable thermal vapor flow changes suction head hydraulic conductivity geotextile drainage temperature gradient lower temperature top column increased suction geotextile ability function capillary barrier capillary rise temperature gradient lower temperature top column decreased suction geotextile ability function capillary barrier changing direction thermal gradient reversed water vapor flow direction effect suction geotextile temperature gradient noticeable effect suction head geotextile positive pore pressure developed geotextile adjacent soil drainage elsevier ltd rights reserved
eye gaze important social cue human communication serves predictor changes attention indicates social interest even affects evaluation objects looked however needs shown strong nonverbal signal affects social aesthetic evaluations social settings study presented natural scenes two faces three gaze conditions showing different directions gaze participants evaluated faces looked showed direct averted gaze attractiveness aesthetic well trustworthiness social experiment faces looking directly perceiver rated attractive trustworthy experiment direct gaze condition omitted faces looked another face judged trustworthy experiment participants remember directions gaze two faces demonstrating dependence judgement actual situation excluding memory explanation experiment confirmed gaze effects depend direction gaze mere presence another person findings show gazing real world settings affects social aesthetic evaluations
advances medical imaging computer programming two dimensional axial images processed reformatted views sagittal coronal three dimensional virtual models represent patients anatomy processed digital information analyzed detail orthopedic surgeons perform patient specific orthopedic procedures use printing rising become prevalent medical applications last decade surgeons researchers increasingly utilizing technology flexibility manufacturing objects printing type manufacturing process materials plastic metal deposited layers create object digital model additive manufacturing method advantage fabricating objects complex freeform geometry impossible using traditional subtractive manufacturing methods specifically surgical applications printing techniques generate models give better understanding complex anatomy pathology patients aid education surgical training also produce patient specific surgical guides even custom implants tailor made surgical requirements clinical workflow printing technology continues evolve orthopedic surgeons embrace latest knowledge technology incorporate clinical practice patient specific orthopedic applications paper written help orthopedic surgeons stay date emerging technology starting acquisition clinical imaging printing patient specific applications orthopedics presents necessary steps prepare medical images required printing reviews current applications printing patient specific orthopedic procedures discusses potential advantages limitations printed custom orthopedic implants suggests directions future development printing technology reported beneficial patient specific orthopedics creation anatomic models surgical planning education surgical training patient specific instruments printed custom implants besides anatomically conformed patient surgical requirement printed implants fabricated scaffold lattices may facilitate osteointegration reduce implant stiffness however limitations including high cost implants lead time manufacturing lack intraoperative flexibility need addressed new biomimetic materials investigated use printing increase utilization printing technology orthopedics one computer platform developed easy planning seamless communications among different care providers studies needed investigate real clinical efficacy printings orthopedic applications
accommodation refers ways family members act alleviate child symptoms distress context youth obsessive compulsive disorder ocd anxiety accommodation may contribute development maintenance disorder review theory research literature accommodation including measures accommodation findings support idea accommodation preferred parenting strategy sequelae accommodation negative often associated parent sibling distress accommodation assessed targeted treatment youth ocd anxiety conclude identifying several areas future research including development interventions specifically target accommodation evaluation potential family factors implicated accommodation exploration construct accommodation childhood disorders
background children deletion syndrome reported socio communicative impairments although many children diagnosed intellectual disability autism spectrum disorder asd populations seldom used control groups hence information regarding syndrome specific socio communicative challenges lacking method parental concerns regarding everyday communication investigated means children communication checklist geurts twenty children chronological age years years months compared children idiopathic children idiopathic comorbid asd groups matched fluid intelligence chronological age core language scores results neglect inadequate use context information prevalent children children idiopathic nonverbal communication seemed less impaired children idiopathic asd conclusion pragmatic language skills developmental trajectories children merit investigation
paper presents analytical closed form expressions uncover contributions nodal active reactive power injections active reactive power flows transmission lines electrical network paying due homage current voltage divider laws similar spirit baptize power divider laws derived circuit theoretic examination power flow expressions constitution power divider laws reflects topology voltage profile network demonstrate utility power divider laws analysis power networks highlighting applications transmission network allocation transmission loss allocation identifying feasible injections respecting line active power flow set points
menopausal estrogen loss leads increased bone loss soy isoflavones act selective estrogen receptor modulators role bone turnover unclear primary outcome assessing changes plasma bone turnover markers secondary outcomes assessing changes cardiovascular risk markers including insulin resistance blood pressure lipid profile performed double blind randomized parallel study women within years onset menopause randomized soy protein isoflavone spi soy protein alone daily months significant reduction type collagen crosslinked beta telopeptide ctx bone resorption marker spi supplementation versus compared supplementation versus months also significant reduction type procollagen propeptide pnp bone formation marker spi supplementation versus marked months following spi significant reduction fasting glucose fasting insulin insulin resistance systolic blood pressure whereas significant changes parameters observed significant changes fasting lipid profile diastolic blood pressure either preparation significant increase tsh reduction free thyroxine spi supplementation though free tri iodothyronine unchanged conclusion soy protein isoflavones may confer beneficial effect bone health analogous mode action antiresorptive agents albeit less magnitude significant improvement cardiovascular risk markers significant increase tsh reduction free thyroxine spi supplementation indicating detrimental effect thyroid function american society bone mineral research
alzheimer disease progressive neurodegenerative disease accumulating evidence suggests inflammatory response oxidative stress autophagy involved amyloid beta beta induced memory deficits silibinin silybin flavonoid derived herb milk thistle well known hepatoprotective activities study investigated neuroprotective effect silibinin beta injected rats results demonstrated silibinin significantly attenuated beta induced memory deficits morris water maze novel object recognition tests silibinin exerted anxiolytic effect beta injected rats determined elevated plus maze test silibinin attenuated inflammatory responses increased glutathione gsh levels decreased malondialdehyde mda levels upregulated autophagy levels beta injected rats conclusion silibinin potential candidate treatment anti inflammatory antioxidant autophagy regulating activities
studies examined relationship interpersonal stress body image young adults present experimental study tests effect peer stress general weight specific state body dissatisfaction moderating role gender appearance importance university students aged years randomly assigned three conditions peer stress elicited vicarious rejection scenarios based appearance personality rejection control results supported significant complex peer stress effect state body dissatisfaction moderated gender appearance importance specifically males personality based peer stress condition reported greater general body dissatisfaction compared males appearance based rejection conditions participants exposed appearance based peer stress including placing low value appearance reported greater weight dissatisfaction compared rejection control personality rejection conditions females participants reporting high appearance importance shown report greater body dissatisfaction general results hold implications prevention early intervention programs young adults suggest stress management training could target peer domain population copyright textrum ltd rights reserved
paper deals alternative determination state belt gear realize themeasurements newly developed device designed measurement diagnostics belt gears main task detect belt slip expressed coefficient elastic creep specific slip measuring device measurements regarding performed input revolutions electric motor torque belt gear constant whereas tensioning force belt gear changes also possible perform measurement input revolutions electric motor tensioning forces constant torque changes
surveyed participants responses received facebook status updates last two weeks higher lower narcissistic entitlement exploitativeness associated desiring responses others trying make oneself appear popular facebook dissatisfied responses received becoming angry retaliating individuals respond one status updates higher lower narcissistic leadership authority associated claiming one typically received response others assertion appear based reality elsevier ltd rights reserved
primary myelofibrosis pmf chronic philadelphia negative myeloproliferative neoplasm characterized hematopoietic stem cell derived clonal myeloproliferation involving especially megakaryocyte lineage better characterize altered expression micrornas might contribute pmf pathogenesis previously performed integrative analysis gene microrna expression profiles pmf hematopoietic stem progenitor cells hspcs allowed identify mir upregulated microrna predicted target highest number downregulated mrnas elucidate role mir hematopoietic differentiation present study demonstrated mir enforced expression normal hspcs promotes megakaryocytopoiesis gene expression profiling upon mir overexpression allowed identification genes commonly downregulated microrna overexpression pmf cells among suppressor cytokine signaling socs confirmed mir target luciferase assay western blot analysis showed reduced level socs protein well stat activation mir overexpressing cells furthermore transient inhibition socs expression hspcs demonstrated socs silencing stimulates megakaryocytopoiesis mimicking phenotypic effects observed upon mir overexpression finally disclose contribution mir upregulation pmf pathogenesis performed inhibition experiments pmf hspcs showed mir silencing led socs upregulation impaired megakaryocyte differentiation taken together results describe first time role mir normal hspc differentiation suggest increased expression subsequent downregulation target socs might contribute megakaryocyte hyperplasia commonly observed pmf patients
article presents innovative concept applying graph databases transport information systems model graph database presented together implementation data structures search operations graph transformation concept relational model graph data model developed schema graph database proposed public transport information system purposes realization methods illustrated use search function based cypher query language
effective elements step largely align principles professional treatment recovery models professional addiction workers review barriers promoting alcoholics anonymous clients
paper automatic control system biped robot tracking based camera designed hardware system idea modular design used selection cmos camera capture images use tmsdm chip image processing running algorithm steering engine control board atmega core realization serial communication dsp atmega gone spi software algorithm design collected image needs processed median filtering binary processing identify boundary black line white board according gray value corresponding instruction called system make biped robot walking trail finally
suffix trees highly regarded data structures text indexing string algorithms mcreight weiner given string length vertical bar vertical bar suffix tree takes nodes links often presented compacted version suffix trie latter trie digital search tree built suffixes compaction process replaces maximal chain unary nodes single arc suffix tree requires labels arcs substrings encoded pointers equivalent information contrary arcs suffix trie labeled single symbols theta nodes links suffix tries worst case unary nodes interesting question suffix trie stored using nodes present linear size suffix trie guarantees nodes use new technique reducing number unary nodes stems results antidictionaries instance using linear size suffix trie able check whether pattern length vertical bar vertical bar occurs log vertical bar sigma vertical bar time find longest common substring two strings vertical bar vertical bar vertical bar vertical bar log vertical bar sigma vertical bar time alphabet sigma elsevier rights reserved
hormonal male contraception clinical trials began method based use exogenous testosterone alone combination progestin suppress endogenous production testosterone spermatogenesis studies using testosterone alone showed method effective adverse effects addition progestin increases rate extent suppression spermatogenesis common adverse effects include acne injection site pain mood change including depression changes libido usually mild rarely lead discontinuation current development includes long acting injectables transdermal gels novel androgens may androgenic progestational activities surveys showed men accept new male method female partners trust partner take oral male pills partnership government nongovernment agencies academia industry may generate adequate interest collaboration develop market first male hormonal contraception
reading people eyes valuable skill interpersonal interaction although number studies investigated visual patterns relation perceiver interest intentions goals little known eye gaze comes differentiating intentions love intentions lust sexual desire address question conducted two experiments one testing whether visual pattern related perception love differs related lust one testing whether visual pattern related expression love differs related lust results show person eye gaze shifts function goal love lust looking visual stimulus identification distinct visual patterns love lust could theoretical clinical importance couples therapy two phenomena difficult disentangle one another basis patients self reports
estimate production function agricultural output eastern africa incorporating climate variables disaggregated growing non growing seasons find substantial negative effect within growing season variance precipitation simulate predicted climate change region find resulting output reduction simulation also demonstrates substantial potential economic benefits mitigating effects within growing season precipitation variability conventional technologies flexible planting rainwater harvesting scale potential loss predicted climate change elsevier rights reserved
sustainable strategy conjunctive water management must include information temporal spatial availability natural resource water shortages dry seasons farmers upper plain chao phraya river basin thailand increasingly using groundwater meet irrigation needs evaluate possibilities conjunctive water management area spatial temporal changes water table younger terrace aquifer investigated first regional geomorphological map based field surveys remote sensing previous environmental studies developed well data analyzed relation rainfall streamflow yield pumpage data interpolated using geostatistical techniques results analyzed via integrated zoning based color theory applied multivariate visualization analysis results indicate areas would suitable groundwater extraction conjunctive management framework regard natural hydrogeological processes effects human interaction kriging results compared geomorphological map geomorphological areas exhibit distinct hydrogeological patterns western fans exhibit best potential expansion conjunctive use whereas borders northern fans exhibit lowest potential
background tumorigenesis kind pathology marked infinite proliferation restrained apoptosis compared normal cells abnormal expression proto oncogenes apoptosis inhibition essential tumor growth confirmed molecular biologic immunologic studies hypofunction host immune system also drives development metastasis malignant tumors bcl critical role regulating apoptosis overexpressed several cancers material methods study constructed dual function small hairpin rna shrna vector containing bcl silencing shrna tlr stimulating ssrna examined effect tumor cell growth proliferation results stimulation functional vector vitro promoted significant apoptosis mfc cells regulating expression apoptosis related proteins induced secretion type ifns importantly functional vector effectively inhibited subcutaneous mfc cell growth single shrna ssrna treatment vivo natural killer cells required effective tumor suppression tlr shown play helper role activation cells cells possibly regulating expression receptors secretion cytokines conclusions functional vector contained ssrna shrna may represent promising approach tumor therapy
hypothalamic hormone oxytocin plays major role regulation behavior body composition quality survival frequently impaired childhood craniopharyngioma patients due sequelae behavioral deficits severe obesity caused tumor treatment related hypothalamic lesions pilot cross sectional study analyzed emotion recognition abilities oxytocin concentrations saliva urine single nasal administration oxytocin craniopharyngioma patients four craniopharyngioma presented grade lesions limited anterior hypothalamic areas craniopharyngioma grade lesions involving mammillary bodies posterior hypothalamic areas emotional tasks assessed administration oxytocin using geneva multimodal emotion portrayals corpus multidimensional mood questionnaire patients presented detectable levels oxytocin administration nasal administration oxytocin well tolerated resulted increased oxytocin concentrations saliva urine oxytocin administration craniopharyngioma patients postsurgical lesions limited anterior hypothalamus area showed improvements emotional identifications compared craniopharyngioma patients lesions anterior posterior hypothalamic areas focusing correct assignments positive negative emotion categories craniopharyngioma patients improved assignment negative emotions oxytocin might positive effects emotion perception craniopharyngioma patients specific lesions anterior hypothalamic area studies larger cohorts warranted
two dimensional vector features rendered terrain reference highlight features improve intelligibility three dimensional scenes research proposes new screen space based method render solid color polylines polygons terrain using buffer value window coordinates screen space pixel spatial extent real world coordinates calculated pixel color changed spatial extent intersects polyline polygon feature reflect fact polyline going polygon covering pixel compared existing methods method eliminates undesirable rendering artifacts parallel computing schema proposed implemented well improve rendering performance
laparoscopic sleeve gastrectomy lsg gaining popularity treatment morbid obesity simple low cost procedure resulting significant weight loss within short period time lsg safe procedure low complication rate significant complications staple line bleeding stricture staple line leak formation liver splenic abscesses extremely rare consequence lsg liver abscess reported one case report splenic abscess reported five case reports lsg study case report literature review report two cases pyogenic liver abscesses two cases splenic abscesses lsg lsg becomes popular clinicians need aware uncommon potentially serious complications related
study objectives assess impact resident driven sexual health educational initiative inner city cleveland middle school design setting participants resident physicians students grade participated prospective cohort study interventions main outcome measures residents taught sessions topics basic anatomy physiology pregnancy sexually transmitted infections sti contraception safe relationships outcome measures included percentages students able name least different stis contraceptive methods name potential complications stis correctly identify condoms abstinence contraceptive methods also protective sti transmission results significant improvements noted students baseline knowledge human anatomy contraception safe sex practices completion curriculum percentage students able name least forms birth control increased percentage able name least different stis increased follow testing months completion curriculum demonstrated significant knowledge retention residents medical students surveyed described perceived need comprehensive rather abstinence based reproductive health education schools conclusions socioeconomic burden teen pregnancy justifies comprehensive efforts improve reproductive health education
shaping methodological basis professional construction management possible tospeak new direction development construction pricing development cost management system construction cost engineering construction integrating assessment investment costs estimated pricing contract pricing evaluation actual construction costs enabling connect manage aforementioned processes time concept cost engineering construction fixes engineering technical technological basis processes directly indirectly related definition construction costs article presents authors considerations creation implementation cost engineering systems construction thenational territorial corporate levels authors published elsevier ltd
children greater risk adults developing cancer exposed ionizing radiation developing bodies long life expectancy post exposure children require specific attention aftermath nuclear accidents radiation used diagnosis treatment purposes review discuss carcinogenic potential pediatric exposures ionizing radiation accidental diagnostic therapeutic modalities particular emphasis given leukemia thyroid cancers consequences accidental exposures discuss evidence cancers arise result radiotherapy conclude review summary available literature links computer tomography carcinogenesis appropriate actions taken mitigate minimize negative health effects pediatric exposures ionizing radiation future considerations discussed
work consider minimum cost shared steiner arborescence problem ssta problem goal find minimum cost subgraph shared among multiple entities entity able establish cost efficient steiner arborescence ssta recently used literature establish shared functional modules protein protein interaction networks propose cut based formulation problem design two exact algorithmic approaches one based separation connectivity cut inequalities corresponding benders decomposition former model approaches enhanced various techniques including preprocessing stabilized cut generation iii primal heuristics cut management two algorithmic alternatives computationally evaluated compared previously proposed flow based formulation illustrate effectiveness algorithms two types instances derived protein protein interaction networks available previous literature telecommunication access networks elsevier rights reserved
non metallic inclusions defects present steel disrupt homogeneity structure adversely affects mechanical properties extent silo approach based mathematical models successfully used modify control inclusions steel making attempts made deal processes integrated framework computational advancement high promising potential icme integrated computational materials engineering physics based models integrated lead overall increase process understanding control eventually better properties performance material objectives present work using cfd based models understand influence various design process parameters inclusion removal secondary steel making using fem model study effects type characteristics inclusions solid state forming operations finally integrate models order develop integrated modeling framework integrated framework determine extent inclusions tolerated downstream processes without affecting quality properties final steel sheet significantly suggest modifications upstream processes inclusions acceptable limit
correspondence bias refers idea people sometimes give undue weight dispositional rather situational factors explaining behaviours attitudes three experiments examined whether mindfulness non judgmental focus present moment could reduce participants engaged brief mindfulness exercise raisin task control task attention detail task completing typical measure involving attitude attribution paradigm results indicated participants mindfulness condition experienced significant reduction compared participants control attention detail conditions results suggest mindfulness training play unique role reducing social biases related person perception
background anorexia nervosa adolescence increasingly documented numerous quantitative qualitative studies qualitative research focuses subjective experience well established method deepen understanding provide new insights specific diseases objective conducted metasynthesis qualitative studies explore anorexia nervosa experienced adolescents families health professionals provide care compare perspectives review methods five databases medline psycinfo cinhal embase ssci systematically searched qualitative studies reporting participants views anorexia nervosa article quality assessed critical appraisal skills program casp used thematic synthesis examine summarize topics found articles selected develop central themes results included articles seven different countries two domains experience inductively developed analysis constructs beliefs etiological theories anorexia nervosa experience disease points view adolescents parents healthcare providers conclusions found important disparities three stakeholders adolescents underlined psychological emotional aspects experience visible state patients bodies impeded work professionals difficulties shed new light stakes treatment anorexia nervosa adolescence must integrate psychological physical components elsevier ltd rights reserved
nearly years research focused large wood rivers provide basis understanding wood enters rivers wood decays breaks transported downstream least temporarily stable wood influences channel geometry fluxes water sediment organic matter abundance diversity aquatic riparian organisms field based studies led qualitative conceptual models numerical stimulations river processes involving wood numerous important gaps remain however understanding wood dynamics majority research wood rivers focuses small medium sized rivers defined using ratio wood piece size channel width channels narrower locally typical wood piece length small slightly narrower longer wood pieces present medium although diverse geographic regions biomes represented one studies region majority research comes perennial rivers draining temperate conifer forests regional syntheses commonly focus pacific northwest region north america studies originate consequently significant gaps understanding include lack knowledge wood related processes large rivers dryland rivers rivers high low latitudes using wood budget organizing framework paper identifies gaps related wood recruitment transport storage beavers influence dynamics respect wood recruitment lack information relative importance mass tree mortality transport buried surficial downed wood floodplain channel diverse settings knowledge gaps related wood transport include transport distances thresholds mobility small medium rivers respect wood storage limited data longitudinal trends loads within unaltered large great rivers fluctuations load time intervals greater years knowledge gaps relate physical ecological effects wood including magnitude flow resistance caused patterns wood related sediment storage diverse river sizes channel geometry quantification channel floodplain interactions potential threshold effects relation physical processes biotic communities finally knowledge gaps related management large wood river corridors including understanding consequences enormous historical reductions load rivers forested portions temperate zone effectively reintroduce manage existing river corridors includes enhancing public understanding importance addressing knowledge gaps requires case studies diverse rivers well syntheses metadata analyses elsevier rights reserved
work describes design two devices measuring blood volume changes forearm portable device thighs clothes seated position blood volume arrives measurement site left ventricle electrical properties body segment change changes mainly comprise electrical impedance tissue measured injection safely current detection voltage changes due blood flow signal recorded method impedance plethysmogram ipg portable device analog processing converts ipg waveform square pulses microcontroller performs line estimation heart rate accuracy results accomplishes standards association advancement medical instrumentation heart rate monitors measuring ipg thighs clothes hand main inconvenient stray capacitances modify waveform measured signal however proper cares waveform good enough extract heart rate post processing
objectives melatonin levels decrease physiologically age possibly transition menopause plausible influence hormone therapy melatonin poorly understood aim randomized placebo controlled double blind trial investigate effect administration serum melatonin concentrations late premenopausal postmenopausal women study design analyses carried among late premenopausal postmenopausal healthy women participated prospective study finland serum melatonin sampled min intervals baseline months placebo main outcome measures melatonin levels secretion profile months compared placebo results mean melatonin levels mean melatonin exposure level area curve auc mean duration melatonin secretion differ months placebo irrespectively reproductive state however postmenopausal women melatonin peak time acrophase delayed min average months placebo interaction time group detected melatonin level modelled treatment conclusions administration postmenopausal women alters melatonin peak time melatonin levels research larger clinical samples needed better understand effects melatonin profile elsevier ireland ltd rights reserved
aims conduct pilot trial test feasibility guided self help intervention chronic orofacial pain methods pilot randomized controlled trial conducted compare intervention usual treatment total patients chronic orofacial pain randomized either intervention group usual treatment control group validated outcome measures used measure potential effectiveness intervention number domains physical mental functioning short form anxiety depression hospital anxiety depression scale hads pain intensity interference life brief pain inventory bpi disability manchester orofacial pain disability scale mopds illness behavior revised illness perceptions questionnaire ipqr bootstrap confidence intervals computed treatment effect posttreatment months follow adjusted baseline values outcome measure using analysis covariance results posttreatment month follow participants intervention group control group failed complete outcome measures intervention acceptable could feasibly delivered face face telephone although pilot trial powered draw conclusions effectiveness showed significant effects intervention physical mental functioning treatment control conclusion self help intervention acceptable patients allowed better understand self manage chronic orofacial pain showed potential effectiveness outcome domains related functioning illness perception research needed understand cost effectiveness intervention chronic orofacial pain
intracranial hypotension syndrome ihs generally caused cerebrospinal fluid csf leakage complications include bilateral subdural hygroma haematoma herniation cerebellar tonsils epidural blood patch ebp therapy indicated conservative treatment ineffective reported case year old man history postural headache dizziness patient treated bed rest daily hydration fluid weeks however dizziness headache resolve became drowsy disoriented incomprehensible speech magnetic resonance imaging demonstrated diffuse dural enhancement postcontrast study sagging midbrain csf leakage right lateral posterior thecal sac level performed ebp level injected autologous blood slowly trendelenburg position within minutes became alert oriented people place time chose thoracic ebp first line treatment consideration risk cervical ebp spinal cord nerve root compression puncture chemical meningitis also put patient trendelenburg position make blood travel towards site leak untreated ihs may delay course resolution affect patient consciousness delivery ebp via epidural catheter inserted thoracic spine familiar anesthesiologists safe effective treatment patients ihs caused csf leak even
since publication latest world health organization classification significant effort clarification unresolved questions especially help rapidly developing field molecular genetic studies next generation sequencing particular numerous entities within categories myeloproliferative neoplasms mpns myelodysplastic mds mpns extensively studied large published series attempting characterize better define morphologic molecular genetic features emerging genetic landscape maintains robust correlation various disease entities recognized classification scheme based careful integration detailed clinical information bone marrow peripheral blood morphology immunohistology genomics brief review summarizes current guidelines apply diagnosing classical bcr abl negative mpn polycythemia vera essential thrombocythemia primary myelofibrosis common subtypes mds mpn overlap syndromes important recent molecular updates well upcoming changes current classification expected published late also briefly reviewed
existing research shows appeals self interest sometimes increase sometimes decrease prosocial behavior propose inconsistency part due framings appeals different framings generate different salient reference points leading different assessments appeal study demonstrates buying item proceeds going charity evokes different set alternative behaviors donating receiving item return studies establish people willing act give reading former framing latter study establishes ecological validity replicating effect field experiment assessing participants actual charitable contributions finally study provides additional process evidence via moderation proposed mechanism discuss theoretical practical implications findings suggest avenues future research elsevier inc rights reserved
background evaluate computer based computer tomography analysis caliper visual scoring pulmonary function tests pfts predicting mortality patients connective tissue disease related interstitial lung disease ctd ild identify outcome differences distinct ctd ild groups derived following automated stratification caliper variables methods total consecutive patients assorted ctd ilds parenchymal patterns evaluated caliper visual scoring honeycombing reticular pattern ground glass opacities pulmonary vessel volume emphysema traction bronchiectasis scores evaluated pulmonary function tests forced vital capacity diffusing capacity carbon monoxide carbon monoxide transfer coefficient composite physiologic index mortality analysis automated stratification caliper variables evaluated place alongside forced vital capacity diffusing capacity carbon monoxide ild gender age physiology ild gap model using receiver operating characteristic curve analysis results cox regression analyses identified four independent predictors mortality patient age smoking history carbon monoxide transfer coefficient pulmonary vessel volume automated stratification caliper variables identified three morphologically distinct groups stronger predictors mortality functional indices stratified model substituted automated stratified groups functional indices ild gap model maintained model strength area curve auc ild gap auc combining automated stratified groups ild gap model stratified gap model strengthened predictions year mortality ild gap auc respectively stratified gap auc respectively conclusions caliper derived pulmonary vessel volume independent predictor mortality across ctd ild patients furthermore automated stratification caliper variables represents novel method prognostication least robust pfts ctd ild patients
article considers contribution therapeutic jurisprudence theoretical development practical advancement reforms child care law presenting three dilemmas arising israeli youth law care supervision relating substance procedures practice field enquiry examines influence law litigants order advance rules practices therapeutic effects minimize use rules practices antitherapeutic ones following methodology integrate psychosocial findings legal discussion propose therapeutic practices well legal reform make child protection legal regime friendly children families key points family court community imports insights criminology problem solving restorative justice field child protection includes practical suggestions make child protection decisions therapeutic suggests principle parsimony child protection suggests hierarchy interventions different levels need children suggests reform active involvement children child protection decisions suggests emphasis active involvement parents family group conferencing models well mainstream decision making presents suggestions therapeutic judging practices youth court judges
aims describe natural history non neurogenic overactive bladder oab urgency incontinence community dwelling older men methods representative sample community dwelling men aged older defined geographic area sydney australia urinary symptoms assessed using international prostate symptom scores ipss international consultation incontinence questionnaire iciq baseline year follow year follow four hundred eighty eight men without neurological diseases prostate cancer follow history urological treatment baseline included analysis urgency incontinence defined leakage urine occurring weekly defined population oab defined either urgency urgency incontinence according international continence society consensus results men oab baseline received treatment oab benign prostatic enlargement years remaining men sustained remission year year follow ups without treatment men oab year follow remission rate year follow men without oab baseline men oab baseline statistically significant difference found baseline characteristics men sustained remission men persistent symptoms conclusions one three older men non neurogenic oab sustained remission symptoms without medical surgical interventions significant predictor sustained remission identified wiley periodicals inc
purposeto investigate tear film stability secretion according serum hydroxyvitamin levels dry eye patients methodsin retrospective observational study medical charts patients visited department ophthalmology hallym university kangnam sacred heart hospital april august reviewed serum levels measured subjects divided three groups according serum levels sufficient inadequate deficient group eye discomfort measured ocular surface disease index osdi tear break time tbut fluorescein staining score schirmer tear secretion test measured resultsthe mean age years mean serum level tear break time tbut tear secretion positively correlated serum levels pearson correlation test tear break time tbut tear secretion shorter vitamin deficient group compared sufficient group fluorescein staining scores osdi scores different three groups conclusiontear break time tbut secretion correlated serum vitamin levels vitamin status may important factor dry eye syndrome
background aim autism spectrum disorders asd neurodevelopmental disorders without definitive etiology cases environmental factors viral infections linked anomalies brain growth neuronal development functional connectivity congenital cytomegalovirus cmv infection associated onset asd several case reports aim study evaluate prevalence congenital cmv infection children asd healthy controls patients methods cmv genome tested polymerase chain reaction pcr dried blood spots collected birth children asd controls results prevalence congenital cmv infection cases controls conclusion infection rate fold higher patients asd general italian population birth reason detection cmv dna dried blood spots could considered work usually performed asd diagnosis rule secondary form given potential prevention treatment cmv infection study could intriguing consequences least group patients asd
performed oxygen plasma treatment reduced graphene oxide rgo improve surface reactivity respect biomolecular interactions oxygen plasma treated rgo surfaces employed reactive interfaces detection amyloid beta beta peptides pathological hallmarks alzheimer disease target analytes measuring changes electrical characteristics confirmation topographic analysis oxygen plasma treated rgo sensors enhanced surface functionality better antibody immobilization sensing performance fold steeper slope electrical responses versus analyte concentration curve logarithmic scale compared untreated elicited biomolecular reactivity rgo surfaces oxygen plasma treatment remained initial value even aging ambient conditions phenomenon also confirmed pretreating rgo surfaces blocking agent subsequently subjecting antibody immobilization finally feasibility oxygen plasma treated rgo sensors diagnostic tool evaluated clinical samples neural derived exosomal beta peptides extracted apparent patients normal controls contrast untreated sensors oxygen plasma treated rgo sensors showed significant value identification clinical samples subjects results suggest oxygen plasma treatment improves sensor performance without complicated fabrication procedures aid development novel diagnostic tools based carbon nanomaterials
south west asia including middle east one prone regions dust storm events recent years increase occurrence environmental meteorological phenomena remote sensing could serve applicable method detect also characterise events study two dust enhancement algorithms used investigate behaviour dust events using satellite data compare numerical model output satellite products finally validate situ measurements results show use thermal infrared algorithm enhances dust accurately aerosol optical depth modis output dust regional atmospheric model dreamb applied comparing results ground based observations synoptic stations sun photometers used validating satellite products find transport direction locations dust sources synoptic situations events model outputs hysplit ncep ncar presented comparing results synoptic maps model outputs showed using enhancement algorithms reliable way modis products model outputs enhance dust
paper addresses new class train scheduling problems two interconnected high speed rail lines given precise time dependent origin destination demand input proposed systematic schedule synchronization approach focuses satisfying requirements transfer passengers one rail line another rail line aiming minimize passenger waiting times stations crowding disutility trains nonlinear optimization model single line case formulated demonstrate modeling framework train scheduling problems model extended two line case explicitly taking account number boarding alighting passengers connection station using state space representation novel dynamic programming algorithm designed solve single line problem deterministic finite state problem sequential decisions integer coding based genetic algorithm procedure developed solve proposed model general cases two lines simplified real world example illustrates designed schedule beneficial passengers transfer passengers simultaneously
omeprazole one world wide frequently prescribed administered pharmaceuticals humans relief gastro intestinal disorders despite high worldwide consumption omeprazole rarely detected urban wastewaters environmental waters hand human urinary metabolites transformation products formed abiotic processes environment recently documented despite available data however still lack information extent environmental fate occurrence elimination mechanisms efficiencies waste water treatment plants study relevance photodegradation processes environmental persistence omeprazole simulated solar irradiation investigated photodegradation experiments performed distilled water lake river seawater revealed different matrix natural waters significantly affect photolytic behavior investigated compound overall results highlight photodegradation process solar irradiation significantly contributes omeprazole degradation elimination aquatic environment tps formed process identified elucidated using liquid chromatography high resolution mass spectrometry total seven tps identified among four also detected hydrolysis tps microtox bioassay showed solar photolysis efficient detoxify omeprazole tps aqueous solutions finally systematic investigation conducted order provide information removal efficiency occurrence omeprazole metabolites tps wwtps north west greece performing target suspect screening analysis findings revealed presence parent compound metabolites tps wastewaters given however scarce detection omeprazole fairly low concentration levels analytical environmental point view attention given metabolites fps instead parent compound elsevier rights reserved
developing distributed applications particularly distributed real time embedded dre systems difficult complex undertaking due need address four major challenges complexity programming interprocess communication need support wide range services across heterogeneous platforms promote reuse need efficiently utilize resources need adapt changing conditions first two challenges addressed large extent standardized general purpose middleware corba dcom java rmi use black box approach object oriented paradigm frameworks design patterns need support large variety range applications application domains resulted feature rich implementations standardized middleware however feature richness acts counteractive resolving remaining two challenges instead incurs excessive memory footprint performance overhead well increased cost testing maintenance address four challenges leveraging benefits general purpose middleware requires scientific approach specializing middleware software engineering techniques aspect oriented programming aop feature oriented programming fop reflection make specialization task simpler albeit still requiring dre system developer manually identify system invariants sources performance memory footprint bottlenecks drive specialization techniques specialization reuse also hampered due lack common taxonomy document recurring specializations assess strengths weaknesses techniques address requirements paper presents case automated multi stage feature oriented middleware specialization process improves middleware developer productivity middleware performance three specific contributions made paper first contemporary middleware specialization research framed terms three dimensional taxonomy second principles separation concerns used context taxonomy define six stages middleware specialization process lifecycle finally concrete implementation six stage automated middleware specialization process presented along empirical data illustrating benefits accrued using framework
dependence daily photothermal conversion performance stability radiative regime rarely treated literature systems based water collectors objective estimate whether daily performance solar air collectors dependent radiative regime characteristics level daily solar irradiation results obtained comparing performance two solar air collectors whose design almost similar one porous absorber corrugated absorber first daily performance collectors analyzed experimentally clear sky days bucharest romania south eastern europe instantaneous performance collector based porous absorber generally higher collector based corrugated absorber second dynamic models developed validated measurements obtained bucharest two new performance indicators specific time dependent operation defined showh indicators equal steady state transitory operation different values simulations performed collectors operation climate timisoara romania eight days covering four seasons belonging different relative sunshine classes different radiative regime stability levels selected daily level collector based porous absorber effective collector based corrugated absorber instantaneous performance considered corrugated absorber may provide better results morning findings depend stability radiative regime dispersion instantaneous performance values higher less stable radiative regimes days medium cloudiness daily relative sunshine sigma day days fully stable radiative regime overcast sky sigma day collector specific behavior level radiative stability class relative sunshine change time intervals transitory operation traditional coefficient performance may used substitute time averaged value instantaneous coefficient performance however traditional collector efficiency reliable measure time averaged value instantaneous efficiency elsevier ltd rights reserved
paper new light weight highly secured ciphering engine creation methodology called demand ciphering engine odce suggested main feature method ciphering engine secret key kept secrets created user system administrator initiating transmission involved sides exchange secrets design methodology structure system described prototyped using artificial neural network ann main building block system software hardware implementations suggested system performed prove practicability also different experimental tests achieved determine impact suggested method network delay system performance
recent years high speed direct drive spindle motors obtaining attentions due compact structure high efficiency low vibration noise compared high speed machines used electric vehicles refrigerator compressors shaft spindle motor always thicker satisfy mechanical support requirement overall outer diameter spindle motor limited practical use rotor space restricted inner outer side makes machine design process challenging work paper presents detailed design procedure high speed interior spindle permanent magnet motor large volume consumption shaft rotor space fully utilized adopting inverted interior shaped rotor structure firstly split ratio optimized maximum torque density rotor parameters including magnet thickness pole arc angle adjacent pms bridge width optimized finite element analysis fea simulated results show significant improvement output performance torque density increased finally analysis results verified experimental tests rpm prototype machine
several years department mechanical energy management engineering dimeg collaboration sintenergy sri performing researches exploitation tidal currents innovative turbine developed anchored coast require supporting structures seabed reduces installation costs environmental impact machine latest version proposes use two concentric contra rotating rotors order require small non existent stabilizing torque present work machine equilibrium conditions defined cfd analysis lift drag coefficients central deflector calculated together final machine design procedure case study applying procedure machine installed messina strait energy output payback period estimated elsevier ltd rights reserved
heat pipe turbine thermosyphon rankine engine new concept power generation using solar geothermal available low grade heat sources basis engine thermosyphon cycle excellent heat mass transfer characteristics modified incorporate turbine adiabatic region basic configuration closed vertical cylinder functioning evaporator insulated section condenser turbine placed upper end insulated section condenser section plate installed separate high pressure region low pressure region condenser conversion enthalpy kinetic energy achieved nozzles mechanical energy developed turbine converted electrical energy direct coupling electrical generator paper describes development heat pipe turbine concept reality series development steps taken optimise design manufacture also paper attempts made provide relationships developed power terms geometric thermodynamic parameters discuss limitations efficiencies turbines elsevier science ltd rights reserved
using general identities difference operators well technique symbolic computation tools probability theory derive general kth order convolution identities bernoulli euler polynomials achieved use elementary result uniformly distributed random variables identities depend positive real parameters special cases obtain numerous known new identities polynomials particular show well known identities mild matiyasevich bernoulli numbers special cases general formula elsevier inc rights reserved
coagulation factor xii fxii hageman factor plasma protease active form fxiia initiates procoagulant proinflammatory contact system name arises fxii unique mechanism activation induced binding contact negatively charged surfaces various substances capacity trigger fxii contact activation vivo including mast cell derived heparin misfolded protein aggregates collagen nucleic acids polyphosphate fxii deficiency associated bleeding decades factor considered dispensable coagulation vivo however despite fact humans animals deficiency fxii normal hemostatic capacity animal models revealed critical role fxiia driven coagulation thromboembolic diseases addition role thrombosis fxiia contributes inflammation activation inflammatory bradykinin producing kallikrein kinin system pharmacological inhibition fxii fxiia interferes thrombosis inflammation animal models thus targeting fxiia driven contact system seems promising safe therapeutic anticoagulation treatment strategy additional anti inflammatory effects discuss novel functions fxiia cardiovascular thrombotic inflammatory disorders
social decision making often complex requiring decision maker make inferences others mental states addition engaging traditional decision making processes like valuation reward processing growing body research neuroeconomics examined decision making involving social non social stimuli explore activity brain regions striatum prefrontal cortex largely ignoring power social context perhaps complex processes may influence decision making social non social contexts years social psychology social neuroscience research documented multitude processes mental state inferences impression formation spontaneous trait inferences occur upon viewing another person processes rely network brain regions including medial prefrontal cortex mpfc superior temporal sulcus sts temporal parietal junction precuneus among others undoubtedly social cognition processes affect social decision making since mental state inferences occur spontaneously automatically studies looked social inference processes affect decision making social context despite capability inferences serve predictions guide future decision making review integrate person perception decision making literatures understand social cognition inform study social decision making way consistent literatures identify gaps literatures behavioral economics largely ignores social processes spontaneously occur upon viewing another person social psychology largely failed talk implications social cognition processes economic decision making context examine benefits integrating social psychological theory behavioral economic theory
depression significant mental health concern numerous depression questionnaires several scored onto patient reported outcomes measurement information system promisa depression metric study expands unified metric linking depression subscales adult self report asr brief symptom inventory bsi online sample men sex men msm recruited item factor analysis used evaluate dimensionality aggregated measures confirm statistical assumptions linking linking conducted using equipercentile item response theory irt methods equipercentile linking considered varying degrees post smoothing irt based linking used fixed anchor calibration separate calibration stocking lord linking constants three scales broadly unidimensional msm sample slightly higher average depression scores general population mean linking methods provided robust largely comparable results subgroup invariance held age race hiv status given broad comparability across methods crosswalk raw sum scores unified score metric used fixed anchor irt based methods promis provides unified interpretable metric depression reporting results study allow depression subscales asr bsi rescored onto unified metric reasonable caution benefit epidemiological projects aggregating data across various measures time points
objectives hypothesis endoscopic management bilateral vocal fold paralysis bvfp includes cordotomy arytenoidectomy become well accepted alternative tracheostomy however costs quality life benefits endoscopic management examined formal economic analysis study undertakes cost effectiveness analysis tracheostomy versus endoscopic management bvfp study design cost effectiveness analysis methodsa literature review identified range costs outcomes associated surgical options bvfp additional costs derived medicare reimbursement data adjusted dollars cost effectiveness analysis evaluated therapeutic strategies short term long term scenarios probabilistic sensitivity analysis used assess confidence levels regarding economic evaluation results incremental cost effectiveness ratio endoscopic management versus tracheostomy per quality adjusted life year qaly indicating endoscopic management cost effective short term strategy willingness pay wtp threshold qaly probability endoscopic management cost effective tracheostomy wtp threshold analysis demonstrated model sensitive utilities cost short term scenario costs long term care included tracheostomy dominated endoscopic management indicating cost effectiveness endoscopic management wtp conclusions endoscopic management bvfp appears cost effective tracheostomy though endoscopic cordotomy arytenoidectomy require expertise specialized equipment model demonstrates utility gains long term cost advantages endoscopic strategy findings limited relative paucity robust utility data emphasize need economic analysis otolaryngology
gender stereotype theory suggests men generally perceived masculine women whereas women generally perceived feminine men several scales developed measure fundamental aspects gender stereotypes agency communion competence warmth instrumentality expressivity although omitted later version bem original sex role inventory included items masculine feminine addition specific gender stereotypical attributes argue useful able measure two core concepts reliable valid parsimonious way introduce new brief scale traditional masculinity femininity tmf scale designed assess central facets self ascribed masculinity femininity studies used known groups approaches participants differing gender sexual orientation validate scale provide evidence convergent validity expected tmf reliably measured one dimensional masculinity femininity construct moreover tmf correlated moderately gender related measures demonstrating incremental validity tmf predicted gender sexual orientation superior way established adjective based measures furthermore tmf connected criterion characteristics judgments straight laypersons whole sample voice pitch characteristics female subsample contact gay men male subsample outperformed gender related scales taken together long gender differences continue exist suggest tmf provides valuable methodological addition research gender stereotypes
spectroscopically observed suggested sanford transition discrete wire implosions implosion continuous plasma shell aluminum wire array pinches driven electrical generator time history magnesium dopant shell ray emission depended interwire spacing well whether dopant introduced alloy coating aluminum wires diagnose final assembly hot dense shell emitting core region pinch accessible laser interferometry optical emission measurements
since discovery spermatozoon anton van leeuwenhoek ever increasing understanding role reproduction many factors adversely affect sperm quality including varicocele accessory gland infection immunological factors congenital abnormalities iatrogenic systemic endocrine causes diabetes mellitus obesity metabolic syndrome smoking mechanisms responsible association poor sperm parameters ill health may include oxidative stress low grade inflammation low testosterone low sex hormone binding globulin oxidative stress testicular microenvironment may result decreased spermatogenesis sperm dna damage loss sperm motility abnormal sperm morphology low testosterone caused advanced age visceral obesity inflammation associated development cardiovascular disease hence semen analysis important role routine evaluation idiopathic male infertility usually manifested low sperm counts impaired sperm motility absence sperm remains common single diagnostic tool several studies shown inverse relationship semen quality medical disorders review elucidates effect medical disorders social habits sperm quality mechanisms involved impairment sperm quality whether sperm quality used index good health longevity man karger basel
objective aim study retrospectively determine predictive factors decline forced vital capacity fvc initial using texture based automated quantification patients idiopathic pulmonary fibrosis ipf materials methods study patients ipf year follow pulmonary function tests enrolled study texture based automated system used house software quantify six regional patterns normal ground glass opacity ggo reticular opacity honeycombing emphysema consolidation decline fvc defined decrease initial fvc results decline fvc occurred patients mean volume decline fvc mean extents ggo honeycombing emphysema consolidation patients follows respectively multivariate analysis revealed sole independent predictor decline fvc adjusted odds ratio roc analysis showed auc optimal cutoff value sensitivity specificity negative predictive value conclusion less extent accurately predict stable ipf year follow terms fvc
paper present taas web services load testing platform built global platform planetlab taas enables load testing process simple transparent close possible real running scenarios target services first briefly introduce base taas serviceall second provide detailed analysis requirements web service load testing present conceptual architecture well algorithm design improving resource utilization third present implementation details taas finally perform evaluation taas set experiments based testing real web services results illustrate taas efficiently facilitate whole process web service load testing especially comparing existing testing tools taas obtain effective accurate test results copyright john wiley sons ltd
probabilistic design materials fracture critical components modern military turbine engines typical maximum design target risk dtr component failures engine flight hour metric underscores essential role safety design process simultaneously strives achieve performance efficiency reliability affordability throughout life cycle engine traditionally design life management approaches engine materials typically relied extensive testing programs produce large databases fatigue data statistically based life limits derived extrapolation mean fatigue behavior however found statistical behavior fatigue lifetimes given test condition often exhibits bimodal form trends mean minimum fatigue lifetime typically respond differently loading microstructural variables circumstances underlying life limiting mechanisms appear exhibit probabilistic microstructural hierarchy fatigue resistance controlled susceptibility local microstructural neighborhoods early damage growth small cracks findings suggest significant opportunities may exist reductions uncertainty materials life cycle prediction management hierarchies understood controlled paper explores potential implications findings number possible approaches suggested incorporating insights life limiting fatigue methods integrated computational materials engineering icme support optimized life cycle design materials components turbine engines benefits approach appear include substantial improvements model accuracy coupled reduced requirements materials testing potentially leading significant reduction time cost develop validate transition implement new fatigue resistant alloys published elsevier ltd
aims heme derived hemolysis pro oxidative proinflammatory promotes vaso occlusion murine models sickle cell disease scd suggesting enhanced detoxification heme may beneficial nuclear factor erythroid related factor nrf transcription pathway principal cellular defense system responding pro oxidative proinflammatory stress dimethyl fumarate dmf drug approved treatment multiple sclerosis provides neuroprotection activating nrf responsive genes hypothesized induction nrf dmf would beneficial murine scd models results dmf day vehicle methyl cellulose administered days nydd hbss townes scd mice vaso occlusion hallmark scd measured sickle mice dorsal skinfold chambers inhibited dmf inhibitory effect dmf abrogated heme oxygenase inhibitor tin protoporphyrin dmf increased nuclear nrf cellularmrnaofnrf responsive genes livers kidneys dmf increased heme defenses including haptoglobin hemopexin ferritin heavy chain although plasma hemoglobin heme levels unchanged dmf decreased markers inflammation including nuclear factor kappa phospho adhesion molecules toll like receptor dmf administered weeks hbss townesmice decreased hepatic necrosis inflammatory cytokines irregularly shaped erythrocytes increased hemoglobin alter hematocrits reticulocyte counts lactate dehydrogenase plasma heme spleen weights indicating beneficial effects dmf attributable decreased hemolysis innovation studies identify nrf activation new therapeutic target treatment scd conclusion dmf activates nrf enhances antioxidant defenses inhibits inflammation vaso occlusion scd mice
elena lower energy antiprotons mev kev thus increasing factor number antiprotons usable experiments oelert infrastructures must adapted cope another years low energy antiproton physics fit elena ring already crowded hall old kicker generators must relocated new technical building existing new services racks must arranged also height preserving access maintenance capabilities elena beam delivered existing experiments via new transfer lines without compromising possibility maintain visitors path popular place cern new experimental areas designed house new experiments gbar base arrangement future experiments cleaning rooms relocation new technical building control rooms separate building cafeteria conference room also detailed
commonly proposed artifacts understood without reference human intentions fact contend relevance use artifacts intentional action argue artifacts intentions embedded antecedently use artifacts sometimes compelled intend descriptions actions might various reasons inclined believe intend focus argument specific set artifacts namely medical devices considering extended application emergency contraceptive devices although debate whether emergency contraception abortifacient effect argue abortifacient effect effect normally side effect ones action
electric vehicles evs effective solution reducing greenhouse gas emissions atmosphere safety crucial issue automotive industry fault drivetrain may results fatal accident paper discusses dynamic performance evs drivetrain voltage source inverter vsi switch faults presents suitable fault diagnosis algorithm fda remedial strategy applications physical testing drivetrain faults evs expensive extremely difficult therefore nissan leaf lightning evs simulated using validated model permanent magnet synchronous motor pmsm performances investigated faulty drivetrain conditions simulation results show necessity implementing fault tolerant control systems ftcss drivetrain electric motor drives various fault diagnosis algorithms vsi switch faults pmsm drives reviewed merits demerits discussed existing fault tolerant control inverter topologies also reviewed compared based application requirements finally suitable fda fault tolerant control inverter topology drivetrain application recommended maintain safe optimal vehicle performance post fault condition
past two decades lot interest use liposomes lipid based biocompatible carriers drugs administered intravesical route lipidic bilayer structure liposomes facilitates adherence apical membrane surface luminal cells bladder vesicular shape allows opt endocytosis machinery bladder uptake instillation liposomes shown enhance penetration water soluble insoluble drugs toxins oligonucleotides across bladder epithelium empty liposomes composed entirely endogenous phospholipid sphingomyelin could counter mucosal inflammation promote wound healing patients suffering interstitial cystitis recent clinical studies tested multilamellar liposomes composed entirely sphingomyelin novel intravesical therapy interstitial cystitis addition liposomes used delivery platform instillation botulinum toxin overactive bladder patients present review discusses properties liposomes important intrinsic therapeutic effect summarizes recently completed clinical studies intravesical liposomes covers latest developments field
denmark various non traditional students mature age students already kind vocational background applying professional degree fall outside traditional admission requirements individual assessment applicants necessary bachelor programmes article examines case woman named amy mature non traditional university college student becomes social pedagogue severe allergies amy quit job farmer began study become social pedagogue becoming social pedagogue tremendously complex process involves taking new professional identity acquiring new skills order ascertain extent complexity article uses psycho societal approach derived danish german life history research approach article offers brief presentation theoretical methodological framework applied analysing process amy undergoes become social pedagogue analysis demonstrates type significant career change demanding amy filled feelings ambivalence defensiveness
control engineering mathematical model studied process plays important part representing mathematical model inherent errors due parameter variations define parametric structured uncertainties therefore differences mathematical model used design process real plant cases control system needs stabilize process also needs assure certain performances even presence uncertainties unmodeled dynamics disturbance signals measurement noise make process vulnerable paper shows method behavioral modeling simulation gear system moment inertia friction coefficient represent parameters affected uncertainties expressed percentages nominal values modeled process considering classical controller tuned experimentally matlab used represent sensitivity functions time frequency domains nominal cases randomly generated samples worst case scenarios authors published elsevier ltd
objective artesunate art proven potential anti proliferative activities instability poor aqueous solubility limit application anti cancer drug present study undertaken develop coaxial electrospraying novel technique fabricating nanoscale drug delivery systems art core shell nanostructures methods core shell nanoparticles nps fabricated coaxial electrospraying formation mechanisms nps examined physical solid state drug polymer interactions nps characterized ray powder diffraction xrpd fourier transform infrared ftir spectroscopy effects materials electrospraying process particle size surface morphology nps investigated scanning electron microscopy sem drug release nps determined vitro dialysis method results art poly lactic glycolic acid plga chitosan nps exhibited mean particle size relatively high entrapment efficiency release pattern showed initial rapid release within two hours followed slow extended release release pattern approached korsmeyer peppas model conclusions present results suggest core shell nps containing plga potential carriers anticancer drug therapy art
article three aims first reacts doubts expressed recently possibility making generalizations catholicism council trent second discusses different uses term catholic reformation proposes definition involves movement toward universalization divine love third also discusses success confessionalization parts europe reasons top process emphasis disciplining endeavors analysis history confessionalization misses integrative character various devotional practices baroque europe fails pay sufficient attention religious constraints affecting political actors
discuss numerical solution large scale sparse projected periodic discrete time lyapunov equations lifted form arise model reduction periodic descriptor systems extend alternating direction implicit method smith method equations low rank versions methods also presented used compute low rank approximations solutions projected periodic lyapunov equations lifted form low rank right hand side moreover consider application lyapunov solvers balanced truncation model reduction periodic discrete time descriptor systems numerical results given illustrate efficiency accuracy proposed methods
background today sequencing frequently carried massive parallel sequencing mps cuts drastically sequencing time expenses nevertheless sanger sequencing remains main validation method confirm presence variants analysis mps data involves development several bioinformatic tools academic commercial present statistical method compare mps pipelines test comparison academic bwa gatk commercial pipeline tmap nextgene without reference gold standard sanger sequencing panel genes epileptic patients method used number variants fit log linear models pairwise agreements pipelines assess heterogeneity margins odds ratios agreement four log linear models used full model homogeneous margin model model single odds ratio patients model single intercept log linear mixed model fitted considering biological variability random effect results among base pairs sequenced tmap nextgene bwa gatk found average variants single nucleotide variants indels respectively gold standard pipelines similar sensitivities close significantly different specificities trend results obtained single nucleotide variants considered specificity sensitivity pipelines conclusions method allows thus pipeline comparison selection generalizable types mps data pipelines
solve unpunctual delivery low assembly line utilization unbalanced production assembly shop scheduling automotive electronic components enterprise model multi model multiple assembly line mixed lines assembling turns constructed model solved designing series optimal algorithms view meeting punctual delivery period improving utilization assembly lines order fulfillment rate scheduling model constructed different majority similar models virtual sequence new neighborhood structure avoid adjustment cycling improvement defined combined scheduling rules heuristics strategy design three algorithms solving model performance presented algorithms analyzed compared original scheduling results performance comparison results demonstrate virtual tabu vtr tabu algorithm apply small medium scale scheduling problem better performance two performance variation curves three algorithms increasing single parameter analyzed computational results verify effectiveness presented model algorithms improving delivery assembly line utilization order fulfillment rate
forest stands basic units forest inventory mapping stands defined large forested areas homogeneous tree species composition age accurate delineation usually performed human operators visual analysis high resolution vhr infra red images task tedious highly time consuming automated scalability efficient updating purposes paper method based fusion airborne lidar data vhr multispectral images proposed automatic delineation forest stands containing one dominant species purity superior key preliminary task forest land cover database update multispectral images give information tree species whereas lidar point clouds provide geometric information trees allow individual extraction multi modal features computed pixel object levels objects individual trees extracted lidar data supervised classification performed object level order coarsely discriminate existing tree species area interest classification results processed obtain homogeneous areas smooth borders employing energy minimum framework additional constraints joined form energy function experimental results show proposed method provides satisfactory results terms stand labeling delineation overall accuracy ranges international society photogrammetry remote sensing inc isprs published elsevier rights reserved
consider privately determine whether private set owned bob subset another private set owned alice problem many applications online collaboration first propose encoding method encode set vector reduce set computation problem vector computation based encoding scheme two different homomorphic encryption schemes present two efficient protocols private subset problem case private sets subsets known universal set protocols secure semi honest model malicious model show use protocols privately determine whether private number factor another private number john wiley sons ltd
spontaneous spreading depolarizations frequent various forms human brain injury ischemic hemorrhagic stroke trauma worsen outcome recently shown supply demand mismatch transients trigger spreading depolarizations ischemic stroke examined mechanisms triggering recurrent spreading depolarization events many days subarachnoid hemorrhage despite large volumes subarachnoid hemorrhage induced cisternal injection fresh arterial blood rodents electrophysiological recordings detect single spreading depolarization subarachnoid hemorrhage cortical susceptibility spreading depolarization measured direct electrical stimulation topical kcl application suppressed subarachnoid hemorrhage focal cerebral ischemia experimentally induced subarachnoid hemorrhage revealed biphasic change propensity develop peri infarct spreading depolarizations frequency peri infarct spreading depolarizations decreased increased normalized days subarachnoid hemorrhage compared sham controls however ischemic tissue neurological outcomes significantly worse subarachnoid hemorrhage even peri infarct spreading depolarization frequency reduced laser speckle flowmetry implicated cerebrovascular hemodynamic mechanisms worsening outcome altogether data suggest cerebral ischemia required spreading depolarizations triggered subarachnoid hemorrhage creates vicious cycle leading delayed cerebral ischemia syndrome
individual collective acts violence mainly male phenomenon caused complex interactions neurobiological psychosocial factors amazingly topic yet played major role clinical psychiatric literature although disastrous consequences clearly visible everywhere although aggression also belongs archaic human emotions anxiety depression euphoria article gives integrative overview epidemiological neurobiological genetic neuropathological neurochemical hormonal developmental psychosocial theories aggression violence including sociocognitive models hedonistic aspects violence effects violence media processes childhood socialization better knowledge broad spectrum intensively interacting biological psychosocial components resulting violence improves understanding calamitous psychosyndrome also lead effective preventive measures
background aims wistar rat dams exposed limited nesting stress lns post natal days pnd display erratic maternal behavior pups show delayed maturation hypothalamic pituitary adrenal axis impaired epithelial barrier pnd visceral hypersensitivity adulthood little known impact early life stress offspring adulthood influence sex investigated whether male female rats previously exposed lns displays weaning altered corticosterone intestinal permeability microbiota methods wistar rat dams litters maintained pnd limited nesting bedding materials thereafter reverted normal housing weaning pnd control litters normal housing weaning monitored body weight corticosterone plasma levels enzyme immunoassay vivo intestinal colon permeability fluorescein isothiocyanate dextran kda fecal microbiota dna extraction amplification region ribosomal rna gene results weaning lns pups hypercorticosteronemia enhanced intestinal permeability females males body weights similar lns decreased fecal microbial diversity induced distinct composition characterized increased abundance gram positive cocci reduction fiber degrading butyrate producing mucus resident microbes conclusions data indicate chronic exposure lns first week post natally sustained effects monitored weanirig including hypercorticosteronemia leaky gut dysbiosis alterations may impact susceptibility develop visceral hypersensitivity adult rats relevance development irritable bowel syndrome childhood
effective combination antiretroviral therapy cart lead significant reduction prevalence incidence central nervous system cns hiv associated brain disease particularly cns opportunistic infections hiv encephalitis despite cognitive deficits people living hiv also known hiv associated neurocognitive disorders hand become prevalent recent years pathogenesis hand likely multifactorial however recent evidence suggests brain microglial activation likely pathogenic mechanism recent developments positron emission tomography pet brain neuroimaging using novel brain radioligands targeting variety physiological changes brains hiv positive individuals improved understanding mechanisms associated development hand review highlight recent pet brain neuroimaging studies cart era focusing physiological neurochemical changes associated hand people living hiv
propose stochastic programming based tool support adaptive transmission planning market regulatory uncertainties model investments two stages differentiating commitments must made corrective actions undertaken new information becomes available objective minimize expected transmission generation costs time horizon nonlinear constraints resulting kirchhoff voltage law included apply tool bus representation western electricity coordinating council model uncertainty using three scenarios distinct renewable electricity mandates emissions policies fossil fuel prices conclude cost ignoring uncertainty cost using naive deterministic planning methods relative explicitly modeling uncertainty order magnitude cost first stage transmission investments furthermore conclude heuristic rules constructing transmission plans based scenario planning suboptimal deterministic plans
landslide susceptibility evaluation vital disaster management development planning yangtze river three gorges reservoir area study support remote sensing geographic information system factor groups comprising separate subfactors landslide related data layers selected establish susceptibility evaluation model based back propagation neural network including slope aspect plan curvature strata lithology distance faults land use land cover normalized difference vegetation index normalized difference water index distance roads effect rivers model development three layered interconnected neural network structure input layer hidden layer output layer used evaluating landslide susceptibility guojiaba time back propagation algorithm applied calculate weights input layer hidden layer hidden layer output layer results showed effect slope highest weight value two times factors followed strata lithology effect rivers end susceptibility evaluation area divided four zones high high moderate low susceptibility verification receiver operating characteristic curve back propagation neural network derived landslide susceptibility evaluation model drawn results showed area receiver operating characteristic curve prediction accuracy furthermore results obtained article verified comparing existing landslide historical data multiple field verified results lastly landslide susceptibility map help decision makers risk management site selection site planning design control engineering
paper authors discussed detail framework integrating radio frequency identification rfid building information modeling bim technologies proposed framework used computer aided design manufacturing engineering installation processes specific paper explained use rfid technology structural steel components steel beam column paper discussed framework decision support system transmit data read rfid retrieve requested information integrate information analysis process update bim project model decision reached suggested result would great potential saving installation time decrease cost improve safety record achieve better quality end construction process
objectives childhood obesity prevention treatment depends part parents acting agents change children objective measure associations parenting self efficacy parent depressive symptoms preschool child behaviors support healthy growth methods performed cross sectional analysis baseline data randomized controlled trial parenting self efficacy measured using item version parenting sense competence psoc scale alpha parent depressive symptoms measured using center epidemiological studies depression cesd scale child outcomes included diet diet recall physical activity accelerometry sleep parent report media use meals parent report performed separate multiple linear regressions outcome controlling covariates results sample consisted parent child pairs median child age iqr years median child body mass index bmi percentile iqr children hispanic latino children non hispanic black median parent age iqr years parents met criteria depression parenting self efficacy median psoc iqr negatively correlated depressive symptoms rho adjusted models higher parenting self efficacy associated duration child sleep fewer meals eaten front significant interaction parenting self efficacy parental depressive symptoms child sleep duration parenting self efficacy depressive symptoms significantly associated child physical activity child diet conclusions minority population higher parenting self efficacy associated longer child sleep fewer meals front parent depressive symptoms mitigated protective effect child sleep duration
nowadays databases become backbone cloud based applications cloud based applications used every industry today despite popularity wide adoption little still known energy footprint applications particular databases yet reducing energy consumption applications major objective society continue near far future paper study energy consumption three databases used cloud based applications mysql postgresql mongodb series experiments three cloud based applications restful multi threaded application dvd store jpetstore also study impact cloud patterns energy consumption databases cloud based applications often implemented conjunction patterns measure energy consumption using power api tool keep track energy consumed process level variants cloud based applications report choice databases reduce energy consumption cloud based application regardless cloud patterns implemented
background palliative care important part effective cancer care objectives purpose study explore lived experiences nurses providing psychological palliative care cancer patients iran methods hermeneutic phenomenological study performed interviewed oncology nurses understand lived experiences cancer wards psychological palliative care employed seven stage process data analysis results one constitutive pattern palliative care driving force providing psychological comfort patients cancer three associated themes namely stress management empathetic behavior embracing outlook identified conclusions findings present better understanding lived experiences oncology nurses iran regarding phenomena study
children autism spectrum disorder asd require substantial support address core symptoms asd occurring behavioral developmental conditions study explores early diagnostic experiences school aged children asd using survey data large probability based national sample multivariate linear regressions used examine age parent reported developmental concern doctor received asd diagnosis first obtained services children whose parents concerns child verbal communication reported earlier ages outcomes compared children parents verbal communication concerns children whose parents concerns child nonverbal communication unusual gestures movements received earlier diagnosis children whose parents specific concerns
purpose purpose paper introduce new design optimization technique surface mounted permanent magnet smpm machine increase sensorless performance high loadings compromising torque capability design methodology approach smpm parametric machine model created analysed finite element analysis fea software means matlab environment eight geometric parameters machine optimized using genetic algorithms gas outer volume machine namely copper loss per volume kept constant order prevent sensorless performance loss high loading optimization process realized using two loading stages maximum torque minimum ripple nominal load maximum self sensing capability twice load order show effectiveness proposed technique obtained results compared classical one stage optimization realized loading condition separately findings proposed technique fairly good performance results optimization obtained compared one stage optimizations using proposed technique sensorless performance motor highly increased compromising torque capability high loading additionally paper shows self sensing properties smpm machine considered design stage machine originality value related literature design optimization studies sensorless capability smpm motor increasing optimization performance new proposed technique provides achieve good result high load sensorless performance compromising torque capability
role design pattern form software metric internal code architecture object oriented design plays critical role software engineering regarding production cost efficiency paper discusses code reusability frequently exercised cost saving methodology production reviewing existing literature towards study software metrics found studies witnessed incline towards code reusability hence developed simple analytical model establishes relationship design components standard software metric code reusability using case studies three software projects customer relationship management project supply chain management project enterprise relationship management project also testify proposal using stochastic based markov model find proposed system extract significant information maximized values code reusability increasing level uncertainties software project methodologies
next generation advances stress control strategy enable renewable energies solar energy become reliable available critical components power electronics present uncertainties system control malfunctioning process reduces target clean energy development emission reduction thus developing harnessing sustainable energy requires mitigating impact variability source energy impact adaptive stress control deployed proportional integral derivative pid controller minimize thermal stress power switch insulated gate bipolar transistor igbt response challenge fuzzy linear matrix inequality flmi pid controller proposes initiatives customizing parameters pid controller corresponding uncertainty igbts paper uncertainty boost converter evaluated dynamic lmi model takagisugino applied closed loop control overcome instability boost converter parameters authors published elsevier
introduction since first pan hdac inhibitor saha approved fda years ago hdacs including sirt received significant attention due fact aberrant histone deacetylase activtiy implicated variety human diseases cancers virus infection neurodegenerative diseases past years considerable achievement development isoform class selective hdac inhibitors made yielding many drug candidates clinical studies represents state art technology drug discovery arena areas covered review covers new patents articles isoform class selective hdac inhibitors last four years well therapeutic potential compounds expert opinion hdacs represent one promising therapeutic targets particularly tumor therapy though roles cancer still blurry present along advances structural biology homology models lots isoform class selective hdac inhibitors hydroxamic acids benzamides various capping groups found providing promising way circumvent drug toxicity side effect issues well providing chemical probes better understanding biological process related specific isoform
mechanisms integration social services health come dominate debate providing seamless provision health social care working together health social care interface strongly promoted endorsed government documents since late moves towards integration treated suspicion scepticism academic literature many authors highlighting many barriers challenges presented method working yet proposals represent paradigm shift culture parts united kingdom northern ireland integrated health social care system thirty years based empirical study senior health care professionals northern ireland study identifies discusses key issues associated integration concludes experiences northern ireland date overlooked misrepresented could prove extremely valuable gaining understanding challenges benefits integrated arrangements
childhood abuse risk factor development externalizing characteristics disorders including antisocial personality disorder psychopathy however precise relationships particular types childhood maltreatment subsequent antisocial psychopathic traits remain unclear using large sample incarcerated adult male criminal offenders current study confirmed severity overall childhood maltreatment linked severity psychopathy antisocial personality disorder adulthood moreover relationship particularly strong physical abuse antisocial facet psychopathy sexual abuse history uniquely related juvenile conduct disorder severity rather adult psychopathy antisocial behaviors additionally significantly stronger relationship childhood maltreatment juvenile conduct disorder childhood maltreatment aspd psychopathy findings bolster clarify link childhood maltreatment antisocial behavior later life
boundary layer analysis presented stagnation point flow towards nonlinearly stretching shrinking sheet immersed micropolar non newtonian nanofluid material parameter namely vortex viscosity parameter increases friction factor wall couple stresses decrease whereas heat mass transfer rates decrease thermophoresis parameter increases friction factor well heat mass transfer rates increase brownian motion parameter increases friction factor mass transfer rates increase whereas heat transfer rates decrease parameter increases heat transfer rate increases whereas mass transfer rates decrease scmidt number increases friction factor nusselt sherwood numbers increase
offer general procedure design select chp unit based internal combustion engine work devoted provide numerical model estimate amount generated power recovered heat based engine performance features evaluated mismatch numerical results available computational published values also evaluated presented design chp unit economically technically finally grey systems theory proposed multi decision making strategy determine optimal engine applying numerical model vehicles engines provides efficiency power heat production characteristics engine observed optimum operation system must chosen case separately generally using several smaller engines parallel mode preferred single large engine due two major enhancements achieved former scenario longer operation period full load operation reliability level improvement elsevier ltd rights reserved
flow pattern map liquid liquid system circular microchannel experimentally investigated varying confluence angle degree inlet fluids experimental results showing distinguishing nature transition boundaries established using graphical interpretation investigations carried find better objective flow pattern indicator vast flow pattern observations studies advanced feed forward back propagation networks radial basis networks cfn ann ann pnn grnn anfis showed grnn generalized regression neural network showed better prediction prediction techniques value relative impact input variables confluence angle superficial velocity dodecane superficial velocity water flow pattern formation found respectively discrete continuous time state space models system also developed interpreted detail using system identification technique better understanding system elsevier rights reserved
microbiological control cosmetic products always interest industry since microbial spoilage lead product degradation potential human health hazard preservatives added control microbial spoilage increase shelf life product prevent infection humans however safety cases environmental impact questioned often growing interest develop preservative free self preserving cosmetic formulations self preserving products traditional preservatives replaced multifunctional cosmetic ingredients apart delivering main functional property also exhibits antimicrobial property paper explores use combination multifunctional cosmetic ingredients leave skin care products deliver microbiologically safe product products studied emulsion based cream lotion vanishing cream mic cosmetic ingredients screened antimicrobial property compared known preservatives skin care ingredients shortlisted various combinations used prepare cream lotion vanishing cream formulations evaluated efficacy preserve product microbial challenge preservative challenge test pct multiple weekly challenge formulation preservative used control formulations screened cream lotion vanishing cream formulations passed criteria similar control formulation preservative possible develop different options self preserving skin care products efficacious products preservative
objective increasing evidence suggested association sleep duration osteoporosis risk although results previous studies inconsistent knowledge first meta analysis literature quantitative estimates association sleep duration risk osteoporosis population based studies middle aged elderly women methods pertinent studies identified searching pubmed embase databases february five six included studies cross sectional one prospective cohort study included participants three different countries extracted individuals studies meta analysis results pooled odds ratio analysis women years indicated inverse relationship sleep duration osteoporosis overall negative association long sleep duration per day osteoporosis risk observed middle aged elderly women women short sleep duration less per day conclusion meta analysis suggests long sleep duration per day may associated higher risk osteoporosis middle aged elderly prospective cohort studies longer follow periods valid instruments measurement sleep duration dynamic sleep quality warranted support possible relationship sleep duration osteoporosis risk women elsevier inc rights reserved
given undirected graph resistance distance two nodes resistance one would measure two nodes electrical network edges resistors summing distances pairs nodes yields called kirchhoff index graph measures overall connectivity work consider erdos renyi random graphs since graphs random kirchhoff indices random variables give formulas expected value kirchhoff index show concentrates around expectation achieve studying trace pseudoinverse laplacian erdos renyi graphs synchronization class estimation problems graphs results imply acquiring pairwise measurements uniformly random good strategy even vanishing proportion measurements acquired elsevier rights reserved
paper describes design automation development manufacturing automation law enforcement product narcotics identification kit high volume product widely used field law enforcement modifications previous design emphasizing design assembly automation first described new product design automated assembly process developed described paper automation system produce high volume product next described entire project industry academic collaboration experiential manufacturing engineering education project centered approach students gain real world experience creating innovative solutions satisfying needs industry
study explored effects intervening linkages optimism hope subjective health short term myocardial infarction two wave study design used sample consisted myocardial infarction survivors adopting cross sectional design optimism hope predicted subjective health time time controlling baseline subjective health longer significant predictors subjective health time parallel indirect effects seeking social support problem solving significant optimism hope controlling shared variance optimism hope effects remained significant optimism
ask paid work canadian married mothers fathers affected child physical mental condition health problem leads restrictions daily activities using statistics canada national longitudinal survey children youth find married mothers children disabilities less likely engage paid work work fewer paid hours per week statistically significant changes paid work participation hours apparent fathers children find moreover evidence degree specialization within families increases child disability responses consistent traditional gender roles within families may make sense household coping strategy however division labor may generate economic vulnerability mothers compared fathers
objective examine associations social behavioral determinants health sbdh health disparities outcomes women received public health nurse home visits pregnancy parenting support design observational exploratory data analysis comparative outcome evaluation setting extant dataset women served midwestern state including demographics omaha system problems signs symptoms interventions outcome assessments participants women average age years married white methods evaluation dataset constructed included women childbearing age demographics outcome assessments summative sbdh index based institute medicine recommended instruments computed based sign symptom data visualizations developed using microsoft excel outcome significance statistics computed using spss version sas version results outcome evaluation showed positive significant changes baseline public health nurse intervention visualization showed variable concentrations problem specific signs symptoms sbdh index subgroups group differences overall outcome attainment across sbdh index subgroups compared white women minority women greater improvement however despite gains overall minority final ratings lower conclusion informatics approach showed sbdh important factors understanding comprehensive holistic view health health care outcomes potential use large datasets explore intervention effectiveness progress toward health equity related sbdh
objective identify subgroups forensic psychiatric patients based age onset serious mental illness offending assess external validity subgroups theoretically based sociodemographic clinical legal risk related variables method age onset serious mental illness criminal contact ascertained sample patients range sociodemographic clinical legal risk related variables coded assess whether age onset subgroups differed manner consistent literature typologies mentally ill offenders results one quarter sample classified early starters patients whose first offense occurred becoming mentally ill two thirds late starters first offense occurred following illness onset small percentage patients deemed late late starters defined late starters experienced years illness years upon first arrest larger proportion early starters substance use disorder antisocial personality disorder greater number static historical risk factors violence early starters younger upon first arrest previous criminal contacts compared late starters late late starters mental illness found start later life late late starters group also likely married spouse victim index offense conclusion found support distinct subgroups mentally ill offenders based age onset illness criminal contact compared late starters offenses committed early starters may motivated frequently antisocial lifestyle attitudes well instrumental behaviors related substance abuse addition late late starters may represent distinct third subgroup within late starters characterized relatively higher levels functioning social stability future work replicate findings suggest different rehabilitation needs subgroups
current paper describes hybrid control algorithm fuel consumption minimization compound hybrid excavator power train excavator integrates engine assist motor super capacitor converter hybridization original power train power train also incorporates electrically propelled swing motor replaces conventional hydraulic swing motor remove hydraulic loss recuperate kinetic energy swing motion since super capacitor provides required energy electric swing motor sustaining charge presents important consideration power management algorithm design first optimal control problem applied fuel consumption minimization problem algorithm based equivalent fuel minimization strategy ecms applied analyzing behavior state optimal control problem ecms algorithm integrated engine set speed regulator increase overall efficiency diesel engine engine set speed regulator designed change engine set speed depending engine load simulations show ecms near optimum compared dynamic programming results maintaining approximately fuel improvement compared thermostat controller determines power distribution based state charge excellent charge sustaining performance also achieved performance control algorithm verified real world vehicle tests resulting approximately improvement fuel economy compared conventional excavator published elsevier
aim pierre auger observatory measure high statistics flux arrival directions mass composition cosmic rays highest energies since auger collaboration added three new high elevation auger telescopes heat along new infill array field view new telescopes enhancements lowered energy threshold observatory order magnitude combination existing telescopes coihueco vertical field view extended allowing measurement nearby air showers arising primaries energies low paper describe new front end analog board developed process signals generated photomultipliers heat telescopes eighty analog boards produced fully characterized tested main characteristics electronic circuits circuit parameters illustrated elsevier rights reserved
assess efficacy safety single cholecalciferol loading protocol nursing home residents taking vitd supplementation regular basis randomized single blind controlled study one residents march may residents randomly assigned either taken every weeks treatment group individualized regimen according baseline vitd level control group vitd calcium phosphorus parathyroid hormone alkaline phosphatase creatinine serum levels centrally measured day last dose groups baseline control group residents mean age years randomized treatment control group significant difference terms demographic characteristics risk osteoporosis past history vitd supplementation measured baseline respectively sub optimal insufficient deficient vitd whatever study group day last dose cholecalciferol residents reached serum values aeng value non inferiority value superiority reached values aeng treatment control group respectively value non inferiority value superiority mean value higher treatment group biological adverse effects measured study confirmed single loading protocol least effective safe tailored regimen terms ability rapidly normalize vitd values often required dosage vitd reasonably necessary initiate vitd supplementation protocol vulnerable population
video games become one favorite activities american children growing body research linking violent video game play aggressive cognitions attitudes behaviors first goal study document video games habits adolescents level parental monitoring adolescent video game use second goal examine associations among violent video game exposure hostility arguments teachers school grades physical fights addition path analyses conducted test mediational pathways video game habits outcomes six hundred seven grade students four schools participated adolescents expose greater amounts video game violence hostile reported getting arguments teachers frequently likely involved physical fights performed poorly school mediational pathways found hostility mediated relationship violent video game exposure outcomes results interpreted within support framework general aggression model association professionals services adolescents published elsevier ltd rights reserved
leakage current reduction single phase transformerless cascaded bridge inverter investigated paper high frequency common mode loop model typical single phase cascaded bridge system established based model main factors affect leakage current discussed reason typical single phase cascaded bridge inverter fails reduce leakage current explained order solve problem cascaded topology based inverter presented along new modulation strategy ensure stray capacitor voltage free high frequency components way leakage current effectively reduced finally prototype tmsfdsp xcsfpga digital control built performance tests cascaded bridge proposed topologies carried experimental results verify effectiveness proposed solution
rapid development remote sensing technology searching similar image challenge hyperspectral remote sensing image processing meanwhile dramatic growth amount hyperspectral remote sensing data stimulated considerable research content based image retrieval cbir field remote sensing technology although many cbir systems developed studies focused hyperspectral remote sensing images cbir system hyperspectral remote sensing image using endmember extraction proposed paper main contributions method endmembers spectral features extracted hyperspectral remote sensing image improved automatic pixel purity index appi algorithm spectral information divergence spectral angle match sid sam mixed measure method utilized similarity measurement hyperspectral remote sensing images last images ranked descending top retrieved images returned experimental results nasa datasets show system yield superior performance
recent years major global challenge faced manufacturing industry requires low energy consumption low pollution low emission less use non renewable resources excellent market competitiveness cost control capability better protection occupational health safety excellent technical performance address associated multifaceted context environment economy society technology many researchers practitioners thus making great efforts sustainable manufacturing order take challenges comprehensive scientific manner advanced manufacturing equipment cnc machine tools particularly design applications need adapt cope increasing demands sustainability capability features incorporating sustainability design stage cnc machine tools effective measure linking sustainable design analysis machines particular however universally accepted design guidelines design methodologies sustainable cnc machine tools yet present many researchers practitioners focus one two specific technologies reducing energy consumption reducing pollution emissions sustainable performance cnc machine tools study comprehensive quantitative analysis sustainable performance still lacking therefore paper sustainable design index sdi oriented approach presented machine design analysis within cad cae environment expected quantitative analysis oriented applicable engineering manufacture industrial feasible manner analysis model quantitatively evaluates design scheme machine tools four aspects covering environment economy society technology using life cycle assessment lca analytic hierarchy process ahp methods sdi analysis model consists indexing system fully reflect sustainable performance design schemes synthesis algorithm accurately calculate sustainable design index value based following criterion levels energy consumption pollution emissions costs modular design lightweight design security accuracy processing capability enhance application sdi analysis model cad cae environment develop new plugin program written visual basic program calculate sustainable design index value design schemes using original design values weights using approach associated tool developed designers determine sustainable machine design scheme improve sustainable performance machine applying sustainable design index sdi based assessment indicators case study shows sustainable design performance design scheme better design scheme
network processes often represented signals defined vertices graph untangle latent structure signals one view outputs linear graph filters modeling underlying network dynamics paper deals problem joint identification graph filter input signal thus broadening scope classical blind deconvolution temporal spatial signals less structured graph domain given graph signal modeled output graph filter goal recover vector filter coefficients input signal assumed sparse bilinear function filtered graph signal also linear combination entries lifted rank one row sparse matrix xht blind graph filter identification problem thus tackled via rank sparsity minimization subject linear constraints inverse problem amenable convex relaxations offering provable recovery guarantees simplifying assumptions numerical tests using synthetic real world networks illustrate merits proposed algorithms well benefits leveraging multiple signals aid blind identification task
foster care preferred alternative home care necessarily beneficial foster children psychosocial functioning dilemma leaves researchers challenge find factors related foster children social emotional functioning sample dutch foster children examined extent three clusters characteristics akin foster child foster family foster placement related foster children functioning time research multivariate three step hierarchical regression analyses performed three outcome variables externalizing problems internalizing problems prosocial behavior found three clusters foster care characteristics significantly related foster children functioning foster placement characteristics particular interventions aimed foster children explained largest amount variance behavior problems children receiving interventions externalizing internalizing problems possible explanation interventions indicated foster children highest need additional support prosocial behavior particularly related foster family characteristics results mostly line international research careful screening monitoring social emotional functioning foster children may help identify problems early stage addition preventive support offered foster children families need elsevier ltd rights reserved
renewable energies great potential contribute emissions reductions substituting fossil fuels study examines whether renewable energies learning technical change compete forest carbon sequestration cost efficiently achieve carbon target cost efficient abatement solutions obtained using dynamic optimisation model accounts three kinds mitigation options renewable energies abatement forest fossil fuel sectors results show net present cost reaching target approximately billion euros carbon price euro ton furthermore stock renewables deliver almost twice much current electricity production renewables implies contribution meeting emissions target however average cost per unit emissions reduction twice high renewables forest carbon sequestration hence results indicate renewables unable compete forest carbon sequestration unless receive continued government support elsevier ltd rights reserved
background energy efficiency increasingly important property software large number empirical studies conducted topic however current state art provide empirically validated guidelines developing energy efficient software aim study aims assessing impact terms energy savings best practices achieving software energy efficiency elicited previous work identifies resources affected practices possible trade offs energy consumption method performed empirical experiment controlled environment applied two different green software practices two software applications namely query optimization mysql server usage sleep instruction apache web server performed comparison energy consumption system level resource level applying practice results results show practices effective improving software energy efficiency reducing consumption observe applying practices resource usage energy proportional increasing cpu usage increases energy consumption almost linear way also provide reflections empirical experimentation software energy efficiency conclusions contribution shows significant improvements software energy efficiency gained applying best practices design development future work devoted validate best practices improve reusability elsevier inc rights reserved
paper extends hierarchical multiscale approach developed earlier authors model coupled hydro mechanical behaviour saturated granular soils based hierarchical coupling finite element method fem discrete element method dem approach employs fem solve boundary value problem using dem derive required nonlinear material responses fem gauss integration point helps bypass phenomenological constitutive model required conventional fem simulations offers natural pathway scale bridging current extension features key consideration coupled hydro mechanical behaviour saturated granular soil due presence pore fluid flow invoking terzaghi effective stress principle formulation proposed multiscale framework derive effective stress dem solution representative volume element rve embedded gauss point superimposed pore fluid pressure obtain total stress solving coupled governing equations fluid solid mixture extension greatly enriches predictive capacity multiscale approach simulating saturated granular soils relevant wide variety important civil mining applications new approach first benchmarked closed form solutions classical consolidation problems applied simulate globally undrained biaxial compression tests dense loose soils subjected large deformation discuss interesting fluid flow patterns failure modes localisation diffuse liquefaction observed simulations provide detailed cross scale analyses elsevier rights reserved
paper addresses use solar thermal energy continuously generate electrical energy commercially available turbo charger driving electrical generator system based brayton thermodynamic cycle energy provided thermal accumulator propose using air working media compressor element capable producing sufficient boost achieve useful level efficiency cycle operating speed range claimed factory design selection important components system electrical generator starting motor electrical drive rectifying inverting current discussed parametric analysis proves theoretical feasibility model included authors published elsevier ltd
current trend green buildings reflected construction administration buildings residential complexes non profit organization czech green building council czech republic integrates different companies linked economics transform current method construction green energy healthier building one side stands cost green building hand stand operating costs life cycle buildings considerable influence deciding investor aim paper monitoring operating costs respect initial costs green buildings assessed environmentally friendly building new administrative building renovated administrative building administrative building built traditional method construction clearly presents differences operating costs monitored buildings paper operating costs conversion enclosed space number people using facilities article surveys innovative approach facility management development process green buildings results presented based calculations actually achieved values
paper introduce novel three dimensional reconstruction framework ultrasound images using piecewise smooth markov random field mrf model irregularly spaced scan images obtained freehand scanning freehand ultrasound imaging useful system various clinical applications including image guided surgeries interventions well diagnoses due variety scan ranges relatively low cost reconstruction process performs key role system sampling irregularities may cause undesired artifacts ultrasound images generally suffer noise distortions however traditional approaches based simple geometric interpolations pixel based distance weighted methods sensitive sampling density speckle noise approaches generally additional limitation smoothing objects boundaries reduce speckle noise preserve boundaries devised piecewise smooth mrf model developed optimization algorithm framework easily apply individual noise level image pixel specified characteristics ultrasound probe possibly lateral axial positions image result reconstructed volume sharp object boundaries reduced speckle noise artifacts mrf model provides simple segmentation results within reconstruction framework useful various purposes clear visualization corresponding optimization methods also developed tested virtual phantom physical phantom model experimental results show method outperforms existing methods terms interpolation segmentation accuracy method computations performed practical time consumption appropriate resolution via parallel computing using graphic processing units elsevier inc rights reserved
background efficacy catheter ablation asymptomatic persistent atrial fibrillation remains unclear assessed quality life qol exercise performance plasma type natriuretic peptide bnp levels following patients asymptomatic methods results enrolled patients asymptomatic persistent qol assessed questionnaires short form qol questionnaire specific afqlq qol plasma bnp level examined months survey components subsets afqlq significantly improved patients without recurrences patients differences recurrences patients without recurrences increase metabolic equivalents task mets duration maximal exercise plasma bnp decrease linear correlation increased duration exercise plasma bnp decrease conclusions maintenance sinus rhythm successful improved qol plasma bnp level patients asymptomatic persistent may primarily applicable patients previously unrecognized impairment qol
objectives enhance public access prophylaxis lyme disease following identified ixodes scapularis tick bite pharmacist initiated antibiotic therapy assess patient satisfaction pharmacy based service provided setting independent community pharmacy charlestown may october practice description collaborative practice agreement trained pharmacists independent pharmacy identified patients eligible postexposure antibiotic prophylaxis following attachment removal scapularis tick commonly known deer tick dispensed two tablets doxycycline patients included years older provided informed consent estimated time tick attachment hours tick removed within hours visit denied contraindications doxycycline therapy reported telephone access follow patients enrolled study protocol given counseling related doxycycline signs symptoms lyme disease future tick prevention strategies practice innovation pharmacist initiation doxycycline prophylaxis described literature previously successful pharmacist initiation antibiotic prophylaxis may broader implications states endemic lyme disease infectious disease public health concerns main outcome measures patient self reported adverse outcomes satisfaction pharmacy based service results eight patients enrolled study completed follow survey results indicated high level satisfaction pharmacy services provided reports subsequent development lyme disease symptoms major adverse events conclusion project expanded three community pharmacy sites southern rhode island based experience similar pharmacy based collaborative practice models considered highly endemic lyme disease areas
eosinophils constitute important component helminth immunity associated various allergies also linked autoinflammatory disorders including skin disease psoriasis demonstrate functional relationship eosinophils plasmacytoid dendritic cells pdcs related skin diseases previously showed pdcs colocalize neutrophil extracellular traps nets psoriatic skin demonstrate eosinophils found psoriatic skin near neutrophils nets suggesting pdc responses regulated eosinophils eosinophils inhibited pdc function vitro mechanism involve cell contact depended soluble factors pdcs stimulated specific net components eosinophil conditioned media attenuated production interferon ifn alpha affect maturation pdcs evidenced unaltered expression costimulatory molecules pdcs ifn alpha play key role autoimmune skin inflammation data suggest eosinophils may influence autoinflammatory responses impact production ifn alpha pdcs
generalized approach determination transmittance transfer function domain optical waveguide based ring resonator introduced present article delay line signal processing technique developed previous researchers used develop signal flow graph different ring resonator architectures rule already established previous investigator implemented determine overall transmittance frequency responses three different ring resonator architectures presented article parameters describing performance optical filter directly estimated frequency response plot simulated results single double ring architectures compared previously published results waveguide based triple ring resonator architecture proposed frequency response analysis carried article published elsevier
aim study examine growth human eye globe cornea early gestation late adult life globe antero posterior length horizontal vertical diameters corneal horizontal vertical white white diameters posterior pole limbus distances measured using digital calipers postmortem eyes additional pre postnatal data dimensions obtained literature dimensions examined increase rapidly prenatal development postnatal growth differs growth globe antero posterior length vertical horizontal diameters well corneal vertical horizontal diameters stops within year birth logistic analysis consistent asymptotic prenatal growth mode growth completion around year birth horizontal vertical globe diameters ages corneal horizontal diameter always larger vertical diameter differences could detected males females ocular dimensions globe corneal growth take place primarily prenatal growth mode dimensions reach maxima shortly birth suggested cessation growth stimulating signal birth marks end prenatal growth mode small increases next year due cells already stimulated male female eyes age globe cornea dimensions elsevier ltd rights reserved
rats brain dysplasia evoked interruption different stages prenatal neurogenesis show characteristic variations susceptibility seizures depending neurochemical specificity pharmacological agents used evoke seizures verify discrepancy data obtained using different pharmacological models neurochemically neutral electroshocks applied produce brain dysplasia different degrees pregnant wistar rats exposed single dose gamma rays gestation days postnatal day male offspring respectively subjected daily electrical stimulations evoke seizures profiles tonic clonic reactivity electrical stimulation significantly differed observed following pilocarpine kainic acid administration showed minimal intensity tonic maximal clonic responses contrary high tonic low clonic reactivity observed periventricular nodular heterotopias pnhs observed exclusively generally size pnhs correlated positively susceptibility tonic seizures negatively susceptibility clonic seizures analogous correlations size neocortex opposite brains devoid pnhs showed high tonic seizure susceptibility similar therefore concluded pnhs modified type seizure reactivity tonic clonic depending size presence pnhs necessary development seizure susceptibility elsevier rights reserved
asdex upgrade discharge control system dcs distributed real time control system executing complex control monitoring tasks dcs control algorithms implemented coding dedicated application processes programming language algorithm changes required code modification compilation commissioning experienced programmers could perform significant constraint flexibility control system operation design new approach extends dcs capability configuration defined control algorithms composed chains small configurable standard function blocks providing general purpose functions like algebraic operations filters feedback controllers output limiters decision logic later phase graphical editor could help compose modify configuration simulink like fashion building algorithms standard functions result high number elements order achieve similar performance coding essential avoid administrative bottlenecks design consequence dcs executes function block chain context single real time thread application process concurrency issues multi threaded context need considered resulting strongly simplified signal handling zero performance overhead inter block communication instead signal driven synchronization block scheduler derives execution sequence automatically block dependencies defined configuration blocks connecting signals instantiated dynamically based definitions configuration file algorithms thus defined code configuration concept developed view simulink block libraries marte general application modules gam extends dcs virtues distributed computing multi threading growing diversity general purpose blocks dcs framework reach unprecedented degree universality flexibility configuration defined algorithms gradually replace many existing dcs applications finally concept might also become interest upcoming iter plasma control system elsevier rights reserved
drive muscularity associated behaviors exercising dieting growing importance men western societies extreme form lead body image concerns harmful behaviors like exercising misuse performance enhancing substances therefore investigating factors associated drive muscularity especially vulnerable populations like bodybuilders weight trainers help identify potential risk protective factors body image problems using biopsychosocial framework aim current study explore different factors associated drive muscularity weight training men purpose german speaking male weight trainers completed online survey determine extent biological psychological sociocultural factors contribute drive muscularity related attitudes behaviors using multiple regression models findings showed media ideal body internalization strongest positive predictor drive muscularity age held strongest negative association drive muscularity dissatisfaction muscularity body fat related drive muscularity fat free mass index quantification actual degree muscularity person significantly predicted drive muscularity related behavior attitudes body related aspects self esteem global self esteem significant negative predictors drive muscularity since internalization media body ideals presented highest predictive value drive muscularity findings suggest media body ideal internalizations may risk factor body image concerns men leading extreme form disordered eating muscle dysmorphia future research investigate relations drive muscularity age body composition internalization dissatisfaction muscularity body related self esteem using longitudinal study designs limitations concern cross sectional design study self reported body composition measures homogeneity sample
child abuse includes forms physical emotional ill treatment sexual abuse neglect exploitation results actual potential harm child health development dignity taiwan child protection medical service demonstration center cpmsdc established protect children abuse neglect analyzed compared trends clinical characteristics cases reported cpmsdc evaluate function cpmsdc approaching child abuse neglect taiwan prospectively recorded children reported child abuse neglect cpmsdc tertiary medical center furthermore analyzed compared age gender scene identifying settings time visits injury type injury severity hospital admission hospitalization duration outcomes based different types abuse different settings abuse neglect identified child abuse cases mean age years incidence highest year old children physical abuse neglect predominant males sexual abuse predominant females neglect common followed physical sexual abuse common identifying setting emergency department neglect commonly reported head neck facial injuries common physically abused children neglected sexual abused children leading longer hospitalization higher injury severity score skin injuries neglect mortality rate cpmsdc could enhance ability alertness inclination professionals identify suspected cases child abuse increase rate registry cases physical abuse higher injury severity score longer duration hospitalization injuries head face neck compared types abuse reported rate neglect highly elevated cpmsdc established study period recognition neglect easy consequent injury especially asphyxia may lead mortality
care pediatric surgical patients limited pediatric facilities perioperative rns basic understanding specialized care children require knowledge set includes understanding basic terminology used describe patient population well developmental stages pediatric patients preoperatively nurse conduct thorough assessment evaluation address anxieties questions patient parent guardian intraoperatively nurse prepared help manage difficult intubation laryngospasm induction extubation difficult access positioning skin care surgical site preparation thermoregulation postoperative care considerations include addressing airway differences vital signs pain assessment management fluid management preparation discharge awareness anatomic physiologic differences developmental stages surgical needs children allow perioperative provide high quality safe care pediatric surgical patient aorn inc
introduction espen guideline presents multidisciplinary focus clinical nutrition inflammatory bowel disease ibd methodology guideline based extensive systematic review literature relies expert opinion objective data lacking inconclusive conclusions recommendations subject full peer review delphi process uniformly positive responses agree strongly agree required results ibd increasingly common potential dietary factors aetiology briefly reviewed malnutrition highly prevalent ibd especially crohn disease increased energy protein requirements observed patients management malnutrition ibd considered within general context support malnourished patients treatment iron deficiency parenterally necessary strongly recommended routine provision special diet ibd however supported parenteral nutrition indicated enteral nutrition failed impossible recommended perioperative management patients ibd undergoing surgery accords general espen guidance patients abdominal surgery probiotics may helpful crohn disease primary therapy using nutrition treat ibd supported ulcerative colitis moderately well supported crohn disease especially children adverse consequences steroid therapy proportionally greater however exclusion diets generally recommended little evidence support particular formula feed nutritional regimens constructed conclusions available objective data guide nutritional support primary nutritional therapy ibd presented recommendations strong recommendations grade strong recommendations grade based sparse evidence grade recommendations good practice points gpp european society clinical nutrition metabolism published elsevier ltd rights reserved
background certain chronic diseases migraine result episodic debilitating attacks neither cause timing well understood historically possible triggers identified analysis aggregated data populations patients however triggers common populations may wholly responsible individual attacks explore hypothesis developed method identify individual potential trigger profiles analysed degree inter individual variation methods applied statistical analysis migraine patient database study patients used paper based diaries days track factors potential triggers premonitory symptoms associated migraine attacks patient univariate associations factors migraine events analysed using cox proportional hazards models results generated individual factor attack association profiles patients average number factors associated attacks four per patient factor profiles highly individual unique patients least one identified association conclusion accurate identification individual factor attack profiles prerequisite testing true triggers development trigger avoidance desensitisation strategies methodology represents necessary development toward goal
paper presents algorithm economic optimization laboratory microgrid microgrid incorporates hybrid storage system composed battery bank hydrogen storage connection external electrical network charging station electric vehicles study impact use renewable energy power systems microgrid programmable power supply emulate dynamic behavior wind turbine photovoltaic field system modeling carried using energy hubs methodology hierarchical control structure proposed based model predictive control acting different time scales first level responsible maintaining microgrid stability second level task performing management electricity purchase sale power grid maximize use renewable energy sources manage use energy storages perform charge parked vehicles practical experiments performed different weather conditions solar irradiation wind results show reliable operation proposed control system elsevier rights reserved
high end computing increasingly bound computations become data intensive data transport technologies struggle keep pace demands large scale distributed computations one approach avoiding unnecessary move processing data seen google successful relatively specialized mapreduce system paper discusses investigation towards general solution enabling situ computation peta scale storage system believe work flexible application specific structured storage key addressing overhead caused data partitioning across storage nodes order manage competing workloads storage nodes research system performance management leveraged ultimate goal general framework situ data intensive processing indexing searching expect provide orders magnitude performance increases data intensive workloads
objective assess accuracy magnetic resonance spectroscopy mrs brain volumetry mild cognitive impairment mci predict conversion probable alzheimer disease methods forty eight patients fulfilling criteria amnestic mci underwent conventional magnetic resonance imaging mri followed mrs tesla unit baseline patients underwent neuropsychological examination mrs brain carried exploring left medial occipital lobe ventral posterior cingulated cortex vpcc using lcmodel software high resolution sequence acquired carry volumetric measurement cortical subcortical parcellation strategy used obtain volumes area within brain patients followed detect conversion probable results year follow patients converted myo inositol occipital cortex glutamate glutamine glx posterior cingulate cortex predicted conversion probable sensitivity specificity positive predictive value negative predictive value overall cross validated classification accuracy volume third ventricle total white matter entorhinal cortex predict conversion probable sensitivity specificity positive predictive value negative predictive value overall cross validated classification accuracy combining volumetric measures addition mrs measures prediction probable sensitivity specificity positive predictive value negative predictive value overall accuracy conclusion either mrs brain volumetric measures markers separately cognitive decline may serve noninvasive tool monitor cognitive changes progression dementia patients amnestic mci results support routine use clinical settings elsevier inc rights reserved
anemarrhena asphodeloides known suppress inflammation lower various fevers determine active component asphodeloides ethanol etoh extract asphodeloides rhizomes fractionized compounds isolated dichloromethane chcl soluble fraction identified methylnyasol nyasol methoxynyasol hydroxy methoxy dehydroxynyasol hydroxybenzaldehyde hydroxyacetophenone four norlignans potently inhibited release beta hexosaminidase immunoglobulin ige dinitrophenol conjugated bovine serum albumin dnp bsa treated rat basophilic leukemia rbl plus phorbol myristate acetate treated isolated rat primary mast cells markers degranulation histamine release intraperitoneal treatment etoh extract significantly suppressed fetal reaction serum histamine release induced compound mice results suggest four active norlignan compounds etoh extract asphodeloides may potential developed medicines treatment allergies inhibiting activation mast cells elsevier masson sas rights reserved
rainwater harvesting technology considered innovative effective mechanism reducing drinking water risks due arsenic contamination water salinity coastal bangladesh however adoption tanks remains elusive studies disaster risk communication predominantly based individual level cognitive modeling approaches fail address role social groups human relations collective social factors dissemination process disaster preventive measures viewpoint social implementation community adoption unfamiliar technology disaster risk mitigation preparedness requires another approach given challenge promote rainwater harvesting technology study area coastal bangladesh study examines role various social networks including cohesive groups friends structural equivalent groups individuals position society spatial groups neighbors three information sharing processing activities hearing observation discussion results show individuals similar cohesive affiliations tend become hearing discussion partners cohesive groups share learning opportunity bounded normative constraints terms direct intimate social relations spatial groups facilitate observation provides visual learning structurally equivalent groups relevant adoption dissemination therefore competition similar social environment influence rainwater tank dissemination activities
work develop conceptual design integrated facility produces biodiesel using solar wind energy carbon dioxide microalgae grown accumulate lipids extracted methanol needed transesterification synthesized carbon dioxide electrolytic hydrogen electricity complex produced using solar panels wind turbines flowsheet formulated multiperiod mixed integer nonlinear programming problem whose solution provides optimal source energy operating conditions year average production mgal biodiesel facility requires investment sic production cost sic gal sic energy consumption gal biodiesel capturing carbon dioxide per biodiesel consuming water including operation cooling tower boiler elsevier ltd rights reserved
introduction testosterone deficiency metabolic syndrome mets strongly associated patients consulting sexual dysfunction may testosterone deficiency providing valuable opportunity assess mets identification variables predicting mets great importance aimsto identify cardiovascular comorbidities risk factors including erectile dysfunction associated mets men aged total testosterone nmol nmol calculated free testosterone pmol gain insight relationship conditions methodsdata collected multicenter cross sectional observational study conducted spain among men visiting men health care offices confirmed diagnosis testosterone deficiency subjects data mets assessment included analysis data available anthropometrics toxic habits cardiovascular comorbidities diagnosis values main outcome measuresthe mets harmonized definition used waist circumference threshold diagnosed classified using international index erectile function iief questionnaire bivariate multivariate logistic regression analyses performed calculate odds ratios ors mets results mean age years prevalences mets respectively increasing age bivariate analysis showed moderate severe obesity peripheral vascular disease pvd variables associated greatest odds mets respectively followed alcohol intake tobacco use testosterone deficiency severity minimal effect disappeared multivariate analysis elevated triglycerides hdl cholesterol mets risk factors associated lower level conclusion high prevalence mets among men testosterone deficiency highlights opportunity assess cardiovascular health patients consulting sexual dysfunction moderate severe obesity pvd alcohol intake significantly increase likelihood mets garcia cruz leibar tamayo romero piqueras luque cardenosa alcaraz metabolic syndrome men low testosterone levels relationship cardiovascular risk factors comorbidities erectile dysfunction sex med
advanced cladding materials potentially enhanced accident tolerance yield different light water reactor performance safety characteristics present zirconium based cladding alloys differences due cladding material properties reactor physics thermal hydraulics characteristics differences reactor physics driven fundamental properties neutron absorption cross section iron iron based cladding also design modifications necessitated candidate cladding materials larger fuel pellet compensate parasitic absorption paper describes three dimensional nodal kinetics simulations reactivity initiated accident ria representative pressurized water reactor iron chromium aluminum fecral silicon carbide fiber silicon carbide ceramic matrix composite sic sic materials study shows similar ria neutronic behavior sic sic cladding configurations versus reference zircaloy cladding however fecral cladding response indicates similar energy deposition shorter pulses higher magnitude due shorter neutron generation time core models based fecral cladding fecral based cases exhibit rapid fuel thermal expansion rate cases resultant pellet cladding interaction may occur rapidly conclusions paper based limited set simulated super prompt ria transients elsevier ltd rights reserved
iodine characterized essential element thyroid tissue baumann efficacy iodine prevent goiter demonstrated marine northern usa severe endemic goiter cretinism almost entirely eliminated continental western europe northern america however large populations elsewhere even places western europe sicily still affected public health consequences iodine deficiency limited endemic goiter cretinism iodine deficiency disorders include also increased neonatal death rate decreased intellectual development although consequences included current estimation global burden disease related iodine deficiency severe iodine deficiency public health problem largely control worldwide still affect isolated places hard reach politically neglected populations emphasize importance maintaining international cooperation efforts order monitor iodine status iodine deficiency adequately controlled identify risk population goal global eradication severe iodine deficiency commercial distribution iodized salt remains appropriate strategy randomized clinical trial new guinea clearly showed correcting severe iodine deficiency early pregnancy prevents endemic neurological cretinism supports essential role thyroid hormones maternal origin normal fetal development first trimester pregnancy fetal thyroid still functional randomized clinical trial congo also showed correcting severe iodine deficiency pregnancy prevents myxoedematous cretinism particularly prevalent affected congolese areas
ranking items essential problem recommendation systems since comparing two items simplest type queries order measure relevance items problem aggregating pairwise comparisons obtain global ranking widely studied furthermore ranking pairwise comparisons recently received lot attention crowdsourcing systems binary comparative queries used effectively make assessments faster precise rankings order learn ranking based training set queries labels obtained annotators machine learning algorithms generally used find appropriate ranking model describes data set best paper propose probabilistic model learning multiple latent rankings using pairwise comparisons novel model capture multiple hidden rankings underlying pairwise comparisons based model develop efficient inference algorithm learn multiple latent rankings well effective inference algorithm active learning update model parameters crowdsourcing systems whenever new pairwise comparisons supplied performance study synthetic real life data sets confirms effectiveness model inference algorithms
fractional derivatives powerful tools solving problems science engineering paper analytical algorithm solving fractional differential difference equations sense jumarie modified riemann liouville derivative described demonstrated algorithm tested time fractional differential difference equations rational type via symbolic computation three examples given elucidate solution procedure analyses lead closed form exact solutions terms hyperbolic trigonometric rational functions might subject adequate physical interpretations future copyright john wiley sons ltd
effect change noise amplitudes overdamped diffusive systems linked unperturbed behavior means nonequilibrium fluctuation response relation formula holds also systems state independent nontrivial diffusivity matrices show application experiment two trapped hydrodynamically coupled colloids one subject external random forcing mimics effective temperature nonequilibrium susceptibility energy variation driving example formulation improves earlier version depend time discretization stochastic dynamics scheme holds generic systems additive noise easily implemented numerically thanks matrix operations
introduction meta analyses useful increase knowledge strengthen evidence antidepressant treatment supplementary individual studies methods pooled analysis four multicenter open label prospective non interventional studies performed provide evidence antidepressant effectiveness tolerability agomelatine day large number non selected german outpatients major depressive disorder main analysis performed weeks subpopulations weeks descriptive statistical methods results overall patients pre treated antidepressants concomitant psychiatric diseases medication antidepressants psychotropic medication observed depressive symptoms improved according clinical global impression cgi weeks response observed cgi times upper normal value patients showing preexisting elevations study start one patient developed hepatitis reversible symptoms treatment discontinuation adr predominantly occurred within first weeks treatment mean weight body mass index bmi remained unchanged weeks conclusion pooled data analysis depressed patients clinical practice evaluated weeks subpopulations also analyzed weeks agomelatine effectively reduced depressive symptoms cgi response remission good general tolerability
aim present study investigate first time relationship circadian preference mood seasonality adolescents end participants female male completed morningnesseveningness questionnaire children adolescents seasonal pattern assessment questionnaire children adolescents determine circadian preference mood seasonality respectively evening types achieved significantly higher mood seasonality scores intermediate morning types intermediates morning types agreeing previous studies young adults adults present data indicate significant relationship eveningness higher mood seasonality adolescents
study tries analyze morphological hydrological changes establish relationship sandwip island integration remote sensing geographic information systems gis study concludes recent years data different parts island response different cycle coastline change associated hydrological dynamics resulted net loss coastline net loss coastal area erosion processes increase water depth near shore active along western south western shores erosion island facilitated steep slope bank high tidal water pressure loose bank materials contrast accretions decrease water depth near shore taken place larger parts northern north eastern shores island due backwash sediment deposition favor gentle topographic slope along shores
due technology scaling design conventional type analog digital converter adc uses operational amplifier one building blocks becomes difficult brief new techniques design time based adc tadc uses voltage controlled oscillator vco proposed vco followed time digital converter implemented sigma delta architecture novel architecture using multibit nonlinear internal quantizer feedback digital time converter implemented using phase interpolation employed compensate nonlinear transfer curve vco dynamic element matching calibration used improve robustness tadc mismatch tadc uses implicit sample hold relaxes bounds input frequency tadc implemented cmos technology achieves measured signal noise distortion ratio dynamic range bandwidth mhz
background tennis believed potentially harmful shoulder therefore purpose study evaluate anatomy rotator cuff coraco humeral ligament chl symptomatic non elite junior tennis players high resolution ultrasound methods august september symptomatic non elite junior tennis players mean age standard deviation control group age sex matched subjects included shoulder assessment customized standardized protocol performed body mass index dominant arm years practice weekly hours training racket weight grip eastern western semi western kind strings recorded results abnormalities found ultrasound players two players supraspinatus tendinosis two subacromial impingement ten subacromial bursitis chl thickness resulted comparable dominant non dominant arms multivariate analysis demonstrated association present among chl thickness variables evaluated control group abnormalities found ultrasound subjects sub acromial bursitis statistically significant differences players control group found conclusion symptomatic non elite junior tennis players minor shoulder abnormalities found
serotonergic mechanisms play central role migraine pathology however region specific effects serotonin mediated via multiple types receptors nociceptive system poorly understood using extracellular patch clamp recordings studied action excitability peripheral central terminals trigeminal afferents evoked long lasting ttx sensitive firing peripheral terminals meningeal afferents origin site migraine pain cluster analysis revealed majority nociceptive fibers induced either transient persistent spiking activity prevailing delta theta rhythms receptor antagonist mdl htbid receptor antagonist largely reduced combination completely prevented excitatory pro nociceptive action agonist mcpbg activated spikes mdl dependent manner receptor agonist sumatriptan affect nociceptive firing also triggered peripheral cgrp release meninges blocked mdl evoked fast membrane currents transients fraction trigeminal neurons immunohistochemistry showed expression hta receptors fibers innervating meninges endogenous release degranulated mast cells increased nociceptive firing low histamine strongly activated firing reduced monosynaptic inputs trigeminal delta afferents upper cervical lamina neurons effect blocked mdl consistent central inhibitory effect reduced cgrp release brainstem slices conclusion evokes powerful pro nociceptive peripheral anti nociceptive central effects trigeminal system transmitting migraine pain elsevier ltd rights reserved
california sea lion zalophus californianus agile powerful swimmer unlike many successful swimmers dolphins tuna generate thrust large foreflippers protocol describes robotic platform designed study hydrodynamic performance swimming california sea lion zalophus californianus robot model animal foreflipper actuated motors replicate motion propulsive stroke clap kinematics sea lion propulsive stroke extracted video data unmarked non research sea lions smithsonian zoological park snz data form basis actuation motion robotic flipper presented geometry robotic flipper based high resolution laser scan foreflipper adult female sea lion scaled full scale flipper articulated model three joints mimicking elbow wrist knuckle joint sea lion foreflipper robotic platform matches dynamics properties reynolds number tip speed animal accelerating rest robotic flipper used determine performance forces torques resulting flowfields
oujiang beikou bridge design three tower suspension bridge main span fatigue analysis hangers bridge necessity design ensure safety functionality paper fatigue life assessment hangers proposed considering load effect hanger resistance load effect calculated random traffic model based monte carlo simulation finite element model established ansys random vehicle load spacing simulated model traffic volume predicted resistance calculated according eurocode corrosion effect also taken consideration using curves corroded steel wires noted paper influence lines hangers wide range load effect shared hangers fatigue life hangers three tower suspension bridge much longer lifetime corrosion effect considered corrosion big impact fatigue life length hangers associated fatigue damage hangers two ends three tower suspension bridge side span suffer largest fatigue damage
paper presents methodology applied present time teaching evaluation different courses area manufacturing processes engineering university leon context delimited use content management systems continuous evaluation learning particular moodle platform used structuring contents continuous evaluation courses scope materials science manufacturing processes automation operations analysis changes challenges derived adoption methodology different courses applied presented changes slightly different function compulsory optional character courses well depending number students enrolled
untargeted metabolomic studies generate information rich high dimensional complex datasets remain challenging handle fully exploit despite remarkable progress development tools algorithms exhaustive extraction information metabolomic datasets still non trivial undertaking conversation data mining strategies maximal information extraction metabolomic data needed using liquid chromatography mass spectrometry based untargeted metabolomic dataset study explored influence collection parameters data pre processing step scaling data transformation statistical models generated feature selection thereafter data obtained positive mode generated based untargeted metabolomic study sorghum plants responding dynamically infection fungal pathogen used raw data pre processed markerlynx software waters corporation manchester two parameters varied intensity threshold counts mass tolerance pre processing datasets imported simca umetrics umea sweden data cleaning statistical modeling addition different scaling unit variance pareto etc data transformation log power methods explored results showed pre processing parameters algorithms influence output dataset regard number defined features furthermore study demonstrates pre treatment data prior statistical modeling affects subspace approximation outcome amount variation data model explain predict pre processing pre treatment steps subsequently influence number statistically significant extracted selected features variables thus informed results maximize value untargeted metabolomic data understanding data structures exploration different algorithms methods different steps data analysis pipeline might best trade currently possibly epistemological imperative
work summarized explores application various substrate materials macro fiber composites purpose generating curvature research experimentally determines free strain macro fiber composite full range actuation examines resulting deflections bonded various substrates addition loads applied resulting unimorph cantilever configuration deflections recorded results used validate finite element models used explore design possibilities including bimorph configuration goal work determine substrates maximize curvature unloaded loaded configurations results show using thin high modulus substrates results largest deflection loading
although data based decision making lead improved student achievement data often used effectively schools paper therefore focuses conditions effective data use studied extent school organizational characteristics data characteristics user characteristics collaboration influenced data use accountability school development instruction results hierarchical linear modeling hlm analysis large scale quantitative study show average teachers appear score relatively high data use accountability school development regarding instruction however several data sources used yearly basis among factors investigated school organizational characteristics collaboration greatest influence teachers data use schools
soil organic carbon soc stock important indicator ecosystem service assessments even though considerable fraction total stock stored subsoil current assessments often consider topsoil furthermore mapping efforts hampered limited spatial density topsoil measurements aim study assess soc stock upper soil low input high diversity systems nature reserves flanders belgium compare estimate stock found topsoil upper end combined depth extrapolation measurements limited topsoil four digital soil mapping techniques multiple linear regression boosted regression trees artificial neural networks least squares support vector machines particular attention given vegetation characteristics predictors stock upper boosted regression trees approach informative resulted lowest cross validation errors provided insights relative importance predictors predictors stock upper soil type groundwater level clay fraction community weighted mean cwm variance cwv plant height predictors together cwm specific leaf area aboveground biomass production cwv cwm rooting depth terrain slope cwm mycorrhizal associations species diversity also explained topsoil stock total stock estimates show focusing topsoil considers stock upper given magnitude subsoil dependency typical ecosystem characteristics neglected regional ecosystem service assessments elsevier rights reserved
water resources previously considered free abundant becoming scarce potentially affect human welfare urban areas experience increased water demands directly proportional rate urbanisation causing stress water sources rooftop rainwater harvesting cities towns effective tool recharging depleting aquifers meeting demand water indian national state governments framed rules policies supporting installation rainwater harvesting structures implementation requires acceptance willingness people present study explores awareness rooftop rainwater harvesting systems attitudes towards acceptance among people dehradun india results indicate rooftop rainwater harvesting acceptable people government needs provide supportive implementation plans
control seismic response building fitted magnetorheological dampers considered using optimal static output feedback osof desired damper forces modified bouc wen damper model used two control voltage laws based constraint filter semi inverse quadratic voltage law semi inverse voltage law proposed appear perform least well existing clipped voltage law comparisons available results robust reliability based controller show osof control quite effective controlled response using osof compared linear quadratic guassian lqg passive controllers moderate substantial reduction maximum peak rms responses mostly obtained base configuration sensors using osof control controller cpu time reduces two orders magnitude parametric studies regarding sensor configuration state control weighting matrices performed order obtain effective control effective osof control requires drift feedback drift sensor preferably collocated damper
objective study reveal influence aggressive words versus love words physiological reactivity polygraph implication romanian youngster social life conclusion highlighted participants study assumed aggressive love words stimuli normal environment explanation findings based model effects exposure media violence highlighted living city environment surrounded either aggressive words stimuli love words stimuli teenagers adapted either hostile words love words published elsevier ltd selection peer review responsibility masterprof team
free space optical communication system sun light directly pumped laser signal transmitter demonstrated fresnel lens used primary concentrator collect solar light continuous wave laser power obtained diameter grooved yag rod output intensity modulated video signal via linbo mach zehnder optoelectronic modulator video signal resolution frame frame rate transmitted five meter free space real time high fidelity transmission rate mbps bit error rate lower research shows feasibility applying solar light directly pumped laser free space optical communication significant telecommunications satellites
free radicals play important roles mechanisms underlying lichen planus uric acid important anti oxidant plasma prolactin prl immunomodulatory hormone may promote documented autoimmune disorders systemic lupus erythematosus rheumatoid arthritis psoriasis prl multiple immune stimulatory effects promotes development autoimmune disorders prolactin uric acid may serve biomarkers disease activity lichen planus aim present study evaluate roles depression stress anxiety well serum levels prl potential biomarkers disease activity compare findings control group thirty nine patients clinically diagnosed oral study group age sex matched controls control group selected study serum prl levels measured depression anxiety stress scale used psychometric evaluation patients controls serum level found significantly higher control group well remission phase disease study significant difference serum prl levels cases controls depression stress scores higher study group
low methane content landfill gas suitable feeding engines generally flared type landfill gas may enriched removing inert carbon dioxide innovative process based carbon dioxide captured means accelerated carbonation bottom ash proposed studied purpose process investigated laboratory scale simulating different landfill gas compositions enrichment process able decrease carbon dioxide concentration volume volume requiring bottom ash per landfill gas using result estimated industrial scale plant processing low methane content landfill gas requires bottom ash one year operation specific cost studied enrichment process evaluated well ranges euro per entering landfill gas energy balance showed energy entered landfill gas required carrying enrichment use enriched landfill gas engine producing electricity allows negative carbon dioxide emission elsevier ltd rights reserved
recent research demonstrated people especially susceptible falsememory development suggested misinformation fills causal role explains known outcome chrobak zaragoza however little known factors associated witnessed outcome impact likelihood false memory development present study outcome valence negative positive neutral manipulated participants heard several short stories contained outcome counselor getting promoted lacked causal explanation participants subsequently exposed suggested causal misinformation explained outcome counselor performed impressive act previous day tested memory original event results indicated participants incorrectly reported suggested causal information explained either positive negative outcome opposed neutral outcome theoretical practical implications findings discussed
background traditionally engineering curricula electrical circuits use textbook instruction hands lessons effective approaches teaching terms definitions procedural use formulas build circuits nonetheless students often lack conceptual understanding purpose hypothesis aim study discover facilitate acquisition conceptual understanding hypothesized adding instructional approach form inquiry learning virtual lab would effective relying traditional instruction alone design method students secondary vocational engineering education randomly assigned one two conditions quasi experimental study traditional condition curriculum supplemented computer based practice virtual lab condition traditional curriculum supplemented inquiry learning virtual lab results results showed students virtual lab condition scored significantly higher conceptual understanding cohen procedural skills particular students condition scored higher solving complex problems result occurred complex conceptual procedural problems conclusion since students virtual lab condition acquired better conceptual understanding also developed better procedural skills students traditional condition appears conceptual understanding procedural skills develop iterative fashion
multi standard transceivers useful classical transceivers flexibility multi standard transceivers allow pre defined protocols sense without redesign transceiver front end multiple standard transceivers used global markets also military applications frequency agile filter one basis element multi standard transceivers encryption techniques frequency hopping spread spectrum fhss dhss military applications quick sincgars etc benefit fhss direct sequence spread spectrum encode secret information modulating different arbitrary carriers technique needs frequency agile filters detect signals modulated different carriers several methods design frequency agile filters work current differencing trans conductance amplifier cdta used frequency agile filter design current differencing trans conductance amplifier cdta considerable alternative building block current mode operational amplifiers circuit description cdta suitable design analog filters using capacitors new reconfigurable filter employing cdtas analog signal processing proposed paper filter structure consists cdtas active element two capacitors passive element designed filter operating range applicable different gps protocols implement chip sincgars single channel ground airborne radio system filtering signals filter designed ams technology filter performance tested verified simulations cadence environment
paper proposes new design method called robust dof fuzzy gain scheduling control servo speed control system proposed technique utilizes basic concept dof robust loop shaping whose time domain specifications combined controller design using reference model addition local controllers fixed structure robust controllers whose structure specified simple controller fuzzy approach adopted system identification process global control structure accomplish entirely robust system although design robust control fuzzy system easy genetic algorithms gas simplify control design problem design fuzzy controller average stability margin minimized implementation servo speed control adopted investigate effectiveness proposed controller seen results proposed controller robust performance adopted applications wide operating range institute electrical engineers japan published john wiley sons inc
improved energy efficiency one effective strategies achieving energy sustainability independence locally regionally globally industry accounts global energy usage year suggests potentially significant impact overall energy use rapid development standards efficient equipment components pushing manufacturers towards improvements component level however shown largest efficiency potential actually found higher system levels components serve production processes ventilation hydraulic systems even though importance increasing energy efficiency systemic level widely acknowledged recent years practical approaches seldom discussed literature gap aspiration achievement calls development new approaches foster system efficiency industrial systems paper presents systems analysis corresponding model increase energy efficiency industrial processes involve intensive usage electric motor systems model originates traditional value stream mapping three case studies representing three different industrial processes conducted develop validate model total energy efficiency measures identified address actions beyond component levels alongside identifications energy efficiency measures model promotes creation conditions cross functional worker participation applying model knowledge skills gained industrial personnel working improved energy efficiency maintenance production processes used immediately generate improvement suggestions paper concludes model based simplified energy focused value stream mapping could broaden scope energy efficiency actions engage larger group workers within organisation increase systems efficiency used practical tool finding continuous improvement possibilities result strengthened competitiveness cost effective sustainable manufacturing elsevier ltd rights reserved
background immunotherapy initiated early first presentation relapsing remitting multiple sclerosis associated improved long term outcomes one therefore speculate early initiation highly effective immunotherapies average efficacy superior typical first line therapies could improve relapse disability outcomes however common treatment strategy commence firstline therapies followed treatment escalation patients continue experience treatment disease activity monitoring approach logical current lack effective regenerative remyelinating therapies behoves consider high efficacy treatment strategies disease onset including induction therapy order prevent irreversible disability objective systematic review evaluate effect high efficacy immunotherapies different stages methods systematic review literature reporting outcomes treatment fingolimod natalizumab alemtuzumab different stages carried results conclusions twelve publications reporting relevant information included systematic review literature suggests treatment high efficacy immunotherapies potent suppressing relapse activity initiated early delay diagnosis evidence reported disability mri outcomes inconclusive author published elsevier open access article license http creativecommons org licenses
background intestinal fibrosis stricture formation common feature inflammatory bowel disease ibd leads significantly impaired quality life affected patients intestinal obstruction well need surgical intervention constitutes major treatment challenge key messages fibrosis results response gut tissue insult inflicted chronic inflammation similarly occurs organs underlying fibrogenic mechanisms complex dynamic involving multiple cell types interrelated cellular events large number soluble factors owing breakdown epithelial barrier ibd luminal bacterial products leak interstitium induce innate immune response mediated activation immune non immune cells environmental factors well chronic inflammation certainly impact quality quantity intestinal fibrosis finally composition intestinal extracellular matrix dramatically altered chronic gut inflammation actively promotes fibrosis mechanical properties conventional view intestinal fibrosis inevitable irreversible process gradually changing light improved understanding cellular molecular mechanisms underline pathogenesis addition clinical observations patients undergo strictureplasty shown stricture formation reversible conclusions identification unique mechanisms intestinal fibrogenesis create practical framework target block specific fibrogenic pathways estimate risk fibrotic complications permit detection early fibrotic changes eventually allow development treatment methods customized patient type degree intestinal fibrosis karger basel
goal study explicate lower order facets extraversion related psychopathology used bottom approach specific extraversion scales comprehensive personality inventories used model facets latent factors collected self report interview measures broad range psychopathology large community sample replicating previous findings using similar approach naragon gainey watson naragon gainey watson markon structural analyses yielded four factors positive emotionality sociability assertiveness experience seeking scores latent dimensions related psychopathology correlational analyses two sets regressions first series used four facets predictors second included composite scores big five domains additional predictors results revealed striking level specificity predicted positive emotionality displayed especially strong negative links depressive symptoms diagnoses sociability also negatively related psychopathology showing particularly strong associations indicators social dysfunction negative symptoms schizotypy social anxiety social aloofness restricted affectivity assertiveness generally weak associations bivariate level negatively related social anxiety positively correlated forms externalizing finally experience seeking substantial positive associations broad range indicators related externalizing bipolar disorder also displayed negative links agoraphobia differential correlates demonstrate importance examining personality psychopathology relations specific facet level
result power train electrification electric hybrid vehicles electromagnetic compatibility vehicles comprehensively affected especially power electronic components operated battery voltages around produce broadband eml inside vehicle prove compliance normative requirements considering vehicles inner emc eml measurements component level used testing drive inverter requires electric motor load mechanically loaded another inverter driven system possibly affecting measurement load torque generated outside shielded chamber mechanical connection two drives chamber wall shielded quite difficult realize thus work passive load developed modeling impedance behavior existing motor thus bushing setup load torque generation used drive inverters test setup according cispr circuit realized model load drive inverters typically used electric vehicles finally results emi measurements passive network modeled drive compared
epidermal growth factor receptor egfr associated pathway critical key regulator crc development progression monoclonal antibodies moabs cetuximab panitumumab directed egfr represent major step forward treatment metastatic colorectal cancer mcrc terms progression free survival overall survival several clinical trials however activity anti egfr moabs appears limited subset patients mcrc studies highlighted acquired resistance anti egfr moabs biochemically converge ras raf mek erk pik akt mtor pathways recent data also suggest acquired resistance anti egfr moabs accompanied inhibition egfr internalization ubiqutinization degradation prolonged regulation well established autophagy self cannibalization process considered associated resistance anti egfr moabs therapy additionally autophagy induced anti egfr moabs acts protective response cancer cells thus inhibition autophagy treatment egfr moabs result autophagic cell death combination therapy comprising anti egfr moabs autophagy inhibitors would represent multi pronged approach could evolved active therapeutic strategy mcrc patients elsevier rights reserved
objective programs view individuals capable taking active role managing illness gained importance europe united states article describes implementation evaluation group psychoeducational cognitive behavioral treatment programs department psychiatry psychotherapy ludwig maximilian university munich germany past years methods implementing psychoeducational programs first step establish cognitive behavioral psychotherapy dispel myth schizophrenia patients programs also provided patients mood disorders substance use disorders groups include topics psychoeducation illness establishing rewarding activities stress management cognitive therapy relapse prevention results patients schizophrenia mood disorders schizophrenia major depression bipolar participated illness management groups learn illness treatment learn skills manage illness patients expressed satisfaction programs research supported effectiveness conclusions individuals severe disorders benefit psychoeducational cognitive treatment programs programs adapted level neuropsychological functioning compensate cognitive deficits emotional overload findings suggest providing information illness coping skills patients relatives important treatment outcome
production decline analysis considered robust method obtain flow parameters reservoir properties original gas place although advanced blasingame production decline analysis methods vertical wells fractured wells horizontal wells conventional reservoirs widely used blasingame production decline type curves multi fractured horizontal wells mfhw considering stimulated reservoir volume srv shale gas reservoirs yet compared conventional gas reservoirs multi flow mechanisms darcy flow diffusion adsorption desorption complex flow behaviors mfhw exist shale gas reservoirs bringing big challenge analyzing rate decline performance wells thus paper based material balance equation consideration adsorption desorption material balance pseudo time blasingame decline type curves modified extend theory blasingame production decline analysis shale gas reservoirs considering nonlinearity caused gas desorption diffusion complex flow mfhw numerical method applied paper obtain blasingame type curves based perpendicular bisection pebi grids numerical model considered srv developed solution obtained using control volume finite element method fully implicit method blasingame type curve validated simplify model blasingame production decline type curves mfhw considering srv shale gas reservoir plotted computer programming five flow regimes including early formation linear flow early radial flow compound linear flow second radial flow pseudo steady flow recognized compared modified blasingame type curves presented paper ones traditional pseudo time tendency underestimate value normalized rate normalized cumulative production normalized integral derivative cumulative production reserve effects relevant parameters including srv radius outer region radius permeability srv region outer region langmuir pressure langmuir volume diffusion coefficient type curves analyzed well work expands understanding mfhw flow behaviors shale gas reservoirs used estimate reservoir properties srv reserves types reservoirs elsevier rights reserved
objective evaluate effects protocol involving soft tissue techniques neural mobilization techniques management patients frequent episodic tension type headache fetth chronic tension type headache ctth design randomized double blind placebo controlled trial setting rehabilitation area local hospital private physiotherapy center participants patients women men diagnosed fetth ctth randomly assigned groups interventions placebo superficial massage soft tissue techniques neural mobilization techniques combination soft tissue neural mobilization technigues main outcomes measures pressure pain threshold ppt temporal muscles points supraorbital region point frequency maximal intensity pain crisis score headache impact test hit evaluated variables assessed intervention end intervention days intervention results groups increase ppt reduction frequency maximal intensity hit values time points intervention compared baseline group cases group highest ppt values lowest frequency hit values intervention conclusions application soft tissue neural mobilization techniques patients fetth ctth induces significant changes ppt characteristics pain crisis effect activities daily living compared application techniques isolated interventions american congress rehabilitation medicine
background aims gambling disorder related illegal acts gdria often crucial events gamblers entourage study designed determine predictive factors gdria methods participants gamblers reporting least three dsm american psychiatric association criteria assessed basis sociodemographic characteristics gambling related characteristics personality profile psychiatric comorbidities multiple logistic regression performed identify relevant predictors gdria relative contribution prediction presence gdria results multivariate analysis revealed higher south oaks gambling scale score comorbid addictive disorders lower level income gdria predictors discussion conclusion original finding study comorbid addictive disorder effect might mediated disinhibiting effect stimulant substances gdria studies necessary replicate results especially longitudinal design explore specific therapeutic interventions
hakodate watanabe hospital held pharmacist led multidisciplinary psychiatric pharmacotherapy conferences since september order optimize pharmacotherapy effects holding regular conferences correction high dose antipsychotic polypharmacy prevention reduction adverse reactions antipsychotics reduction drug costs investigated psychiatric inpatients prescribed antipsychotics results revealed number antipsychotics number drugs significantly reduced chlorpromazine equivalent dose significantly reduced approximately drug costs significantly reduced yen regard effects laboratory test data blood glucose hemoglobin alc hbalc levels significantly reduced addition patients assessed unchanged using clinical global impression change cgi indicating absence significant changes severity clinical psychiatric symptoms results confirm psychiatric pharmacotherapy conferences effective promoting appropriate use antipsychotics reducing incidence metabolic adverse reactions elevation blood glucose also reducing drug costs results suggest psychiatric pharmacotherapy conferences encourage psychiatric medical teams adjust prescriptions sharing information effective optimizing pharmacotherapy
energy management comprises planning operation energy production energy consumption units home energy management system sometimes called smart grids energy management system optimizes energy usage informing consumer live basis corresponding consumption units home appliances generally scheduled operate various power ratings none turned solve problems associated power demand paper proposes effective solution making modification already existing electric meter implementing markov chain algorithm algorithm makes use information particularly power generated power available time based obtained information three modes operation namely custom mode limited mode full power mode software implementation done using proteus software hardware details ant implementation presented paper fuzzy rules used determine power gets distributed matlab software used demonstrate prototype hardware demonstrated using picfa microcontroller
paper presents parameter identification equivalent circuit based proton exchange membrane fuel cell model model represented two electrical circuits one reproduces fuel cell output voltage characteristic thermal characteristic output voltage model includes activation concentration ohmic losses describe static properties double layer charging effect delays fuel oxygen supplies effects provide model dynamic properties addition novel thermal model studied ballard nexa fuel cell proposed latter includes thermal effects stack fan significantly improve model accuracy parameters electrical thermal equivalent circuits estimated basis experimental data using evolution strategy resulting parameters validated measurement data obtained nexa module comparison indicates good agreement simulation experiment addition simulations identified model also suitable usage real time fuel cell emulators emulator presented paper additionally proves accuracy obtained model effectiveness using evolution strategy identification fuel cell parameters
paper presents innovative approach measure pressure patterns associated motility peristaltic movements upper gastrointestinal tract approach based inexpensive easy fabricate thin film aluminum strain gauge pressure sensors using flexible polyimide film kapton substrate structural support sensors fabricated using well established standard photolithographic wet etching techniques sensor area allowing fabrication process high level sensors integration four sensors suitable placing single catheter strain gauges bend pressure applied consequently electrical resistance changed fabricated sensors feature almost linear response overall sensitivity mmhg readout control electronics developed flexible kapton ribbon cable together sensors bonded wrapped around catheter like structure sequential acquisition different signals carried microcontroller bit adc sample rate per sensor signals presented user friendly interface developed using integrated development environment software qtcreator ide better visualization physicians
two types geotextile investigated experimental filters raw wastewater pre treated septic tank intermittently dosed filtered hydrostatic pressure beginning filter reactor comprised nine filters made geotextiles three types end start period filters removed due high outflow instability four months working hydraulic capacities remaining filters efficiencies cod bod removal similar types geotextile cod bod small statistically significant difference ammonium nitrogen removal observed probably due different structure biological removal tot relatively poor similar geotextile types mean concentration matter accumulated geotextiles one order magnitude higher conventional activated sludge concentrations last weeks experiments values basic pollution indicators effluent lower maximum permissible values according polish law
genus ajuga used traditionally food medicine aim study investigate antidiabetic anti alzheimer diseases skin protective antioxidant activities essential oil extracts ajuga chamaecistus subsp scoparia boiss rech together identification chemical composition dipheny picrylhydrazyl radical azino bis ethylbenzothiazloine sulfonic acid radical cation scavenging activity metal chelating activity reducing power content total bioactive compounds general toxicity enzyme inhibitory potential essential oil ethanol extract water decoction plant evaluated phenolics profile extracts analyzed using reverse phase high performance liquid chromatography diode array detector chemical composition essential oil determined using gas chromatography gas chromatography mass spectroscopy techniques essential oil could significantly inhibit activity alpha glucosidase mmol acarbose equivalents alpha amylase mmol acarbose equivalents acetylcholinesterase gallic acid equivalents butyrylcholinesterase gallic acid equivalents tyrosinase kojic acid equivalents ethanol water extracts showed moderate enzyme inhibitory activity furthermore essential oil strongest antioxidant capacity diphenyl picrylhydrazyl scavenging azino bis ethylbenzothiazloine sulfonic acid scavenging cupric reducing antioxidant capacity ferric reducing antioxidant power metal chelating assays spathulenol thymol octen linalool oxide identified major constituents essential oil quantitative highperformance liquid chromatography analysis indicated coumaric acid gallic acid ferulic acid main phenolic compounds plant results suggested ajuga chamaecistus could useful several applications functional foods cosmetics pharmaceuticals elsevier rights reserved
background evaluate effects tolterodine anterior segment choroidal thickness using pentacam system optical coherence tomography oct pentacam methods total eyes patients female male included study patients underwent regular ocular examination intraocular pressure measurements months antimuscarinic drug tolterodine treatment addition pupil diameter anterior chamber depth anterior chamber volume anterior chamber angle lens thickness measured pentacam oculus inc wetzlar germany system measurements choroidal thickness performed oct spectralis heidelberg engineering heidelberg germany results mean age years years female male patients mean intraocular pressure mmhg treatment mmhg treatment pupil diameters treatment treatment anterior chamber depth treatment mean value subfoveal choroidal thickness administration tolterodine whereas mean choroidal thickness administration tolterodine alterations subfoveal choroidal thickness statistically significant conclusions months therapy tolterodine significant changes anterior segment parameters choroidal thickness
wheat cereal grain one world major food crops recent advances wheat genome sequencing facilitating genomic proteomic analyses however little known possible differences total protein levels hexaploid versus tetraploid wheat cultivars also knowledge phosphorylated wheat proteins still limited performed detailed analysis proteome seedling leaves two hexaploid wheat cultivars triticum aestivum pavon usu apogee one tetraploid wheat turgidum ssp durum senatore cappelli shotgun proteomics data revealed whereas observed significant differences overall high similarity hexaploid tetraploid varieties respect protein abundance observed addition already seedling stage small set proteins differential small usu apogee larger hexaploid wheat cultivars pavon could potentially act growth predictors finally phosphosites identified study retrieved house developed plant ptm viewer bioinformatics psb ugent webtools ptm viewer making first searchable repository phosphorylated wheat proteins paves way depth quantitative phospho proteome wide differential analyses upon specific trigger environmental change
although psoriatic nail lesions small cause considerable discomfort patients adversely affect quality life studies evaluated dermoscopic features psoriatic nails aim study clarify dermoscopic features nail psoriasis identify reflect psoriatic activity biologic treatment psoriasis six patients psoriatic nails twice underwent dermoscopic examination interval weeks used modified nail psoriasis severity index score psoriasis area severity index score identify assess dermoscopic features identified dermoscopic findings disappearance diffuse scaling nail plate transverse step like notches splinter hemorrhages nail bed appearance erythematous borders onycholytic area associated improvement psoriasis area severity index score dermoscopy detect nail changes psoriasis treatment used evaluate treatment success
chronobiological therapies mood disorders include manipulations sleep wake cycle sleep deprivation sleep phase advance controlled exposure light darkness antidepressant efficacy overcome drug resistance targets core depressive symptoms including suicide thus making treatment options tried either alone adjunctive treatments combined common psychopharmacological interventions specific pattern mood change observed chronobiological therapies characterized rapid sustained effects used among combined drugs effects sizes reported effective psychiatric treatments side effects usually marginal absent new treatment protocols developed adapt different clinical settings review deals general principles clinical chronobiology latest findings rapidly developing field
paper argues mind reading hypotheses mrhs kind needed best describe best explain basic acts social cognition considers two popular mrhs one tom two tom theories mrhs face competition form complementary behaviour reading hypotheses cbrhs following buckner mind lang argued best strategy putting cbrhs play appeal theoretical considerations psychosemantics basic acts social cognition particular need based accounts satisfy teleological criterion ability put cbrhs play yet backdrop new competitor mrhs revealed mind minding hypothesis mmhs mmhs capable explaining known facts basic forms social cognition also satisfy teleological criterion conclusion objections concerning theoretical tenability mmhs addressed prospects research canvassed
sustainability balanced approach puts equal focus environment economy society research suggests worker health safety integral dimension social sustainability present research contributes body knowledge assessing quantifying classifying occupational health safety ohs risk associated construction operation maintenance sustainable projects across united states construction industry compares ohs risk encountered nonsustainable counterpart projects researchers conducted credit credit review leadership energy environmental design leed rating system evaluate potential positive negative impact green design elements construction practices associated implementation leed credits ohs construction maintenance workers researchers also quantified ohs risk associated leed credits green projects distributed across united states results show even though large number leed credits neutral toward ohs sustainable construction represented leed projects associated increase base level safety risk finally risk model integrated risk plane analysis classify safety risk associated leed credits risk classification analyses indicate two credits associated unacceptable risk ohs across united states construction industry expected findings research benefit safety professionals academics designers construction stakeholders providing evidence chosen sustainable designs may impact ohs building projects american society civil engineers
based action principle continuous wave doppler radio fuze hardware loop simulation system designed test role fuze doppler signal fuze generated collected using precision operational amplifier opa adjustment processor processor collect signal conversion upload host computer received dopple signal waveform displayed stop threshold accepted finally experimental results show system simulate doppler airfuse fuze
background primary focal axillary hyperhidrosis disorder excessive sweating strongly impact quality life objective compare microwave ablation botulinum toxin injection liposuction curettage treatment primary axillary hyperhidrosis based subjective objective criteria methods systematic review literature published french english january february completed using pubmed embase databases results articles selected based relevance criteria inclusion exclusion three methods proved efficient safe however microwave ablation botulinum toxin better results compared liposuction curettage short term microwave ablation liposuction curettage showed longer lasting results compared botulinum toxin however long term microwave ablation superior liposuction curettage conclusion microwave ablation liposuction curettage botulinum toxin injections safe efficient minimally invasive alternatives treatment axillary hyperhidrosis well designed randomized controlled trials needed compare efficacy techniques
objective assess knowledge attitudes barriers associated practice emergency contraception among women state sikkim india methods november june trained female medical officers interns used standard questionnaire interview women reproductive age attending outpatient gynecology clinics results agreed participate ever heard awareness particularly low among illiterate women common sources information electronic media friends relatives health personnel overall participants heard know timeframe used women ever heard adequate knowledge total sample ever used common barriers using inadequate knowledge perceived non availability considering abortifacient religious beliefs conclusion knowledge practice low among women interviewed need intensive information available methods correct timing international federation gynecology obstetrics published elsevier ireland ltd rights reserved
considerable data support relationship childhood trauma adult personality pathology general little research investigating specific relationships different types childhood maltreatment adult personality disorders present study tested model incorporating five priori hypotheses regarding association distinct forms childhood maltreatment personality pathology psychiatric patients using multiple self report measures personality diagnostic questionnaire edition child trauma questionnaire conflict tactics scale parent child child adult multidimensional neglectful behavior scale step wise linear regressions supported three five hypotheses suggesting independent relationships physical abuse antisocial personality disorder traits emotional abuse cluster personality disorder traits maternal neglect cluster personality disorder traits controlling occurring maltreatment types personality disorder traits results support independent relationship sexual abuse borderline personality traits emotional abuse narcissistic personality disorder traits additionally three unexpected findings physical abuse independently positively associated narcissistic paranoid traits negatively associated cluster traits findings help refine understanding adult personality pathology support future development clinical tools survivors childhood maltreatment elsevier ireland ltd rights reserved
paper presents novel control circuit eliminates signal overshoot inherent digital step attenuators dsa state transitions addition digital delay elements transitions attenuation state insertion loss state delayed respect transition insertion loss state attenuation state prevents unintended signal leakage output eliminating possible signal overshoot since novel technique achieves signal overshoot suppression simple addition digital control circuit area efficient applied digital attenuator without degrading performance present effectiveness proposed technique employed bit dsa resulting reduced overshoot dsa manufactured commercial silicon insulator soi process measurement results show technique successfully suppresses signal overshoot less
identifying origins social bias critical devising strategies overcome prejudice two experiments tested hypothesis young children catch novel social biases brief exposure biased nonverbal signals demonstrated adults results consistent hypothesis experiment found children exposed brief video depicting nonverbal bias favor one individual another subsequently explicitly preferred prone behave prosocially toward target positive nonverbal signals moreover experiment preschoolers generalized bias individuals spread bias observed experiments lays critical foundation understanding way social biases may develop spread early childhood
today modern world requires digital watermarking technique takes redundancy image consideration embedding watermark novel algorithm used paper takes consideration redundancies spatial domain wavelet domain embedding watermark also cryptography based secret key makes algorithm difficult hack help protect ownership watermarking blind require original image coefficient matrices secret keys essential retrieve original watermark makes redundant various intentional attacks proposed technique resolves challenge optimizing transparency robustness using canny based edge detector technique improvements transparency cover image seen computed psnr value
research rainwater harvesting mainly focuses building scale scant information available performance large scale study aims determine potential economic viability meeting non potable water demand rainwater harvesting large scale case amsterdam airport schiphol dynamic model developed analyse scenarios varying rainfall catchment surfaces storage capacity four potential system configurations catchments non potable uses analysed economic performance different water prices storage options study found given sufficient storage catchment size non potable water demand schiphol supplied reducing drinking water demand diminishing returns adding storage catchment system make full supply inefficient current water charges make large scale system configurations viable due high investment costs supply networks storage infrastructure
immune response heparin one common drug induced allergies yet atypical drug hypersensitivity reaction whereas drug induced allergies rare idiosyncratic lifelong allergic response heparin common predictable certain clinical settings transient advances last decade regards structural characterisation heparin antigenic complex contributions innate immunity development animal models provided insights distinctive features hit immune response recent descriptions crystal structure heparin complex alongside biophysical studies clarified structural requirements immunogenicity heparin dependency antibody formation studies interactions bacterial cell walls well epidemiologic associations anti heparin antibody formation infection suggest role immune priming explain rapid evolution isotype switched immune response sensitised patients murine models greatly facilitated investigations cellular basis hit response identified major role cells marginal zone cells key findings yet validated human disease chapter summarise recent investigations hit immune response context major pathways immune activation identify areas uncertainty
present article investigate effects specific nonverbal behaviors signaling dominance submissiveness impression formation outcome expectation soccer penalty kick situation experiment results indicated penalty takers dominant body language perceived positively soccer goalkeepers players expected perform better players submissive body language effect similar video point light displays moreover contrast previous studies found effect clothing red white video condition experiment used implicit association test demonstrate dominant body language implicitly associated positive soccer player schema whereas submissive body language implicitly associated negative soccer player schema implications findings discussed reference future implications theory research study person perception sport
study clarifies within family family links marital functioning child well expanding existing prospective research study tests whether changes parents marital functioning associated corresponding changes children well independent associations exist comparing different families participants members married opposite sex couples children participated five waves larger study marriage army spouses constructive communication verbal conflict marital satisfaction showed family associations parent reported child internalizing externalizing problems contrast within family associations significant parents communication behaviors parents reported lower levels marital satisfaction also reported lower child well whereas change parents communication associated change child well time isolating within family effects important understanding marital child functioning identifying potential targets effective intervention
burullus lake second largest lake along mediterranean sea represents one subjected lakes pollution delta coastline present study explores use landsat data gis assessing water pollution burullus lake egypt multi spectral landsat oli image dated provided necessary information study radiometric atmospheric corrections applied image land use cover map obtained identify natural resources types human activities area surrounding lake three previously developed water quality empirical models bod total nitrogen total phosphorus applied calibrated image gis model generated identify areas recording high levels bod results confirmed lake water subjected pollution multiple sources particularly domestic agricultural drains shallow water lake shores human activities influencing reported high levels water studied pollutants model indicated south western north eastern parts lake polluted parts recording relatively high levels bod respectively results ascertained based water quality investigations relevant research studies lake concluded burullus lake extensively subjected interrupting human activities great negative impact water quality also dataobservation techniques water quality empirical models successful assessing mapping water pollution national authority remote sensing space sciences production hosting elsevier open access article license http creativecommons org licenses ncnd
objectivesgiven many different types professionals working public health diverse roles likely information needs information seeking behaviors problem solving abilities differ although public health professionals often work interdisciplinary teams studies explored information needs behaviors within context teamwork study explored relationship canadian public health professionals perceptions problem solving abilities information seeking behaviors specific focus use evidence practice settings also explored perceptions collaborative information seeking work contexts sought information methodskey canadian contacts public health organizations helped recruit study participants list servs electronic survey used gather data individual information seeking behaviors collaborative information seeking behaviors use evidence practice environments perceived problem solving abilities demographic characteristics resultsfifty eight public health professionals recruited different roles representing canadian provinces one territory significant relationship found perceived problem solving abilities collaborative information seeking behavior individual information seeking results suggested public health professionals take shared active approach problem solving maintain personal control confidence likely collaborate others seeking information complete work task linking evidence actionadministrators public health organizations promote collaboration implementing effective communication information seeking strategies providing information resources retrieval tools public health professionals perceived problem solving abilities influence collaborate seeking information educators public health organizations tailor training information searching promote collaboration collaborative technology systems
